bluuebunny/crossref_metadata_2025_split huggingface dataset:
Structural links from trait emotional intelligence to life satisfaction and depressive symptoms in women with breast cancer: post-traumatic responses as mediators
Authors: Cannavò Marco , Sanchez-Ruiz Maria-Jose , Barberis Nadia 
Published: January 2024

Abstract
Purpose
The diagnosis of a disease such as breast cancer (BC) can be experienced as a sudden, unexpected, and life-threatening event accompanied by considerable uncertainty. This experience can precipitate the development of post-traumatic symptoms and depression. Conversely, certain individuals exhibit the capacity to reframe this traumatic event and transform it into an opportunity for personal growth. Existing research shows that individuals with high trait emotional intelligence (trait EI) tend to experience fewer post-traumatic stress symptoms (PTS), and greater post-traumatic growth (PTG). The aim of this study was to investigate the interrelationship among these variables and specifically examine whether PTS and PTG play a mediating role between trait EI, depression, and life satisfaction.

Methods
Questionnaires were administered to 338 women with BC to assess trait EI, PTS, PTG, depression, and life satisfaction.

Results
Results highlighted that trait EI was negatively related to PTS and depression and positively related to PTG and life satisfaction. In addition, both PTS and PTG showed a mediating role in the relationship between trait EI, depression, and life satisfaction. This study highlights the close link between depressive symptoms and post-traumatic cognitions in women with BC.

Conclusion
Current findings highlight links between trait EI, PTS, PTG, depressive symptoms, and life satisfaction. Clinicians could use these findings when developing interventions aimed at alleviating PTS, such as low mood and worry, and facilitating PTG. This study demonstrated that trait EI can reduce PTS and increase PTG, therefore it is important to include programs aimed at fostering trait EI.
Liposomal bupivacaine versus conventional anesthetic or placebo for hemorrhoidectomy: a systematic review and meta-analysis
Authors: Solis-Pazmino P. , Figueroa L. , La K. , Termeie O. , Oka K. , Schleicher M. , Cohen J. , Barnajian M. , Nasseri Y. 
Published: January 2024

Abstract
Background
Liposome bupivacaine (LB) is a long-acting anesthetic to enhance postoperative analgesia. Studies evaluating the efficacy of the LB against an active comparator (bupivacaine or placebo) on acute postoperative pain control in hemorrhoidectomy procedures are few and heterogeneous. Therefore, we performed a systematic review and meta-analysis comparing LB’s analgesic efficacy and side effects to conventional/placebo anesthetic in hemorrhoidectomy patients.

Methods
We performed a systematic review and meta-analysis of randomised controlled trials investigating the use of LB after haemorrhoidectomy. We searched the literature published from the time of inception of the datasets to August 19, 2022. The electronic databases included English publications in Ovid MEDLINE In-Process & Other Non-Indexed Citations, Ovid MEDLINE, Ovid EMBASE, and Scopus.

Results
A total of 338 patients who underwent a hemorrhoidectomy procedure enrolled in three randomized clinical trials were included. The overall mean age was 45.84 years (SD ± 11.43), and there was a male predominance (53.55% male). In total 194 patients (52.2%) received LB and 144 (47.8%) received either bupivacaine or placebo. Pain scores at 72 h in the LB (199, 266, and 300 mg) were significantly lower than in the bupivacaine HCl group (p = 0.002). Compared to the bupivacaine/placebo group, the time to first use of opioids in the LB group was significantly longer at LB 199 mg (11 h vs. 9 h), LB 266 mg (19 h vs. 9 h), and LB 300 mg (19 h vs. 8 h) (p < 0.05). Moreover, compared to the bupivacaine/epinephrine group, it was significantly lower in the LB 266 mg group (3.7 vs. 10.2 mg) and at LB 300 mg (13 vs. 33 mg) (p < 0.05). Finally, regarding adverse effects, the conventional anesthetic/placebo group reported more pain in bowel movement than LB groups (OR 2.60, 95% CI 1.31–5.16).

Conclusions
Comparing LB to conventional anesthetic/placebo anesthetic for hemorrhoidectomy, we found a statistically significant reduction in pain through 72 h, decreased opioid requirements, and delayed time to first opioid use. Moreover, the conventional anesthetic/placebo group reported more pain in bowel movement than LB groups.
Impact of heterozygous ALK1 mutations on the transcriptomic response to BMP9 and BMP10 in endothelial cells from hereditary hemorrhagic telangiectasia and pulmonary arterial hypertension donors
Authors: Al Tabosh T. , Liu H. , Koça D. , Al Tarrass M. , Tu L. , Giraud S. , Delagrange L. , Beaudoin M. , Rivière S. , Grobost V. , Rondeau-Lutz M. , Dupuis O. , Ricard N. , Tillet E. , Machillot P. , Salomon A. , Picart C. , Battail C. , Dupuis-Girod S. , Guignabert C. , Desroches-Castan A. , Bailly S. 
Published: January 2024

AbstractHeterozygous activin receptor-like kinase 1 (ALK1) mutations are associated with two vascular diseases: hereditary hemorrhagic telangiectasia (HHT) and more rarely pulmonary arterial hypertension (PAH). Here, we aimed to understand the impact of ALK1 mutations on BMP9 and BMP10 transcriptomic responses in endothelial cells. Endothelial colony-forming cells (ECFCs) and microvascular endothelial cells (HMVECs) carrying loss of function ALK1 mutations were isolated from newborn HHT and adult PAH donors, respectively. RNA-sequencing was performed on each type of cells compared to controls following an 18 h stimulation with BMP9 or BMP10. In control ECFCs, BMP9 and BMP10 stimulations induced similar transcriptomic responses with around 800 differentially expressed genes (DEGs). ALK1-mutated ECFCs unexpectedly revealed highly similar transcriptomic profiles to controls, both at the baseline and upon stimulation, and normal activation of Smad1/5 that could not be explained by a compensation in cell-surface ALK1 level. Conversely, PAH HMVECs revealed strong transcriptional dysregulations compared to controls with > 1200 DEGs at the baseline. Consequently, because our study involved two variables, ALK1 genotype and BMP stimulation, we performed two-factor differential expression analysis and identified 44 BMP9-dysregulated genes in mutated HMVECs, but none in ECFCs. Yet, the impaired regulation of at least one hit, namely lunatic fringe (LFNG), was validated by RT-qPCR in three different ALK1-mutated endothelial models. In conclusion, ALK1 heterozygosity only modified the BMP9/BMP10 regulation of few genes, including LFNG involved in NOTCH signaling. Future studies will uncover whether dysregulations in such hits are enough to promote HHT/PAH pathogenesis, making them potential therapeutic targets, or if second hits are necessary.
Dual-language Learners’ Questions and Teacher Responses in Shared Reading in Preschool
Authors: Kucherenko Svitlana , Rydland Veslemøy , Grøver Vibeke 
Published: January 2024

Abstract
The current study used sequential analysis to examine dual-language learners’ (DLLs) questions and their relations to teacher responses in the context of small-group shared reading in preschool. Participants were 235 DLLs aged 3–5 years and 60 lead teachers from multiethnic preschool classrooms in Norway. Results showed that across four different books, children most often asked information-seeking questions (61–79%). Furthermore, children asked comprehension- and explanation-seeking questions more often than factseeking ones. Sequential analysis showed that the quality of teacher responses was highly dependent on the type of questions DLLs asked: preschool teachers consistently offered more extended and explanatory responses to DLLs’ comprehension- and explanation-seeking questions, compared to other types of questions. Our results suggest that in this way, children actively influence the extended talk they are exposed to during shared reading. Moreover, their questions offer possibilities for further back-and-forth exchanges about topics meaningful to DLLs.
Fires Following Earthquake Fragility Functions for Protected Steel Braced Frames
Authors: Covi Patrick , Tondini Nicola , Sarreshtehdari Amir , Elhami-Khorasani Negar 
Published: January 2024

AbstractThe paper describes the outcomes of the analysis of a steel braced frame protected with spray-applied fire resistive material and subjected to fires following earthquake (FFE). Nonlinear time-history analyses were performed in order to evaluate the seismic response. Then, the post-earthquake fire ignitions within selected compartments were considered based on the damage suffered by the structure, which was estimated according to the inter-storey drift ratio and floor acceleration. Natural fire curves were determined by means of zone models. Thus, compartmentation and opening characteristics were included in the analysis. Finally, thermomechanical analyses were completed and failure criteria based on the column and beam displacement and rate of displacement were investigated. The results of the probabilistic analyses were used to produce fragility functions to evaluate the probability of exceeding a limit state conditioned on an intensity measure in the context of FFE.
An exploratory prospective phase II study of preoperative neoadjuvant bevacizumab and temozolomide for newly diagnosed glioblastoma
Authors: Tanaka Toshihide , Tamura Ryota , Takei Jun , Morimoto Yukina , Teshigawara Akihiko , Yamamoto Yohei , Imai Ryotaro , Kuranari Yuki , Tohmoto Kyoichi , Hasegawa Yuzuru , Akasaki Yasuharu , Murayama Yuichi , Miyake Keisuke , Sasaki Hikaru 
Published: January 2024

Abstract
Purpose
This multi-institutional phase I/II study was conducted to confirm the safety and explore the clinical utility of preoperative Bevacizumab (Bev) for newly diagnosed glioblastoma (GB).

Methods
Patients were enrolled based on magnetic resonance imaging (MRI) findings typically suggestive of GB. Preoperative Bev and temozolomide (TMZ) were administered at doses of 10 mg/kg on day 0 and 150 mg/m2 on days 1–5, respectively. Surgical resection was performed between days 21 and 30, inclusive. The safety and efficacy were evaluated in a total of 15 cases by progression-free survival (PFS), changes in tumor volume, Karnofsky Performance Scale (KPS) and Mini-Mental State Examination (MMSE) scores after preoperative therapy.

Results
Tumor resection was performed on a mean of day 23.7. Pathological diagnosis was GB, isocitrate dehydrogenase (IDH)-wildtype in 14 cases and GB, IDH-mutant in 1 case. Severe adverse events possibly related to preoperative Bev and TMZ were observed in 2 of the 15 patients, as wound infection and postoperative hematoma and thrombocytopenia. KPS and MMSE scores were significantly improved with preoperative therapy. Tumor volume was decreased in all but one case on T1-weighted imaging with contrast-enhancement (T1CE) and in all cases on fluid-attenuated inversion recovery, with mean volume decrease rates of 36.2% and 54.0%, respectively. Median PFS and overall survival were 9.5 months and 16.5 months, respectively.

Conclusion
Preoperative Bev and TMZ is safe as long as the instructions are followed. The strategy might be useful for GB in some patients, not only reducing tumor burden, but also improving patient KPS preoperatively.
Trial Registration Number: UMIN000025579, jRCT1031180233 https://jrct.niph.go.jp/latest-detail/jRCT1031180233. Registration Date: Jan. 16, 2017
Social and seismic structural vulnerability in Zihuatanejo, Guerrero, Mexico
Authors: Novelo-Casanova David A. , Suárez Gerardo 
Published: January 2024

AbstractThe spatial distribution of the social and seismic structural vulnerabilities in Zihuatanejo (ZIH), Guerrero, Mexico, was estimated. Social vulnerability was assessed considering twelve indicators, including parameters such as access to health services, education, housing, employment, and unfavorable family conditions. Seismic structural vulnerability was evaluated characterizing the structural features of local houses, assessing the type and age of construction, and the quality of building materials. Surveyed households were randomly selected from a statistically significant sample. Our findings indicate that in the western and eastern areas of ZIH the population has high and very high social vulnerability. The main factors that condition these levels of social vulnerability are low-income, female-headed families, and households with marginal access to information technology, such as internet and telephone. Although seismic ground amplification in ZIH is relatively low, the regions to the west and southwest of the city are zones where the impact of strong earthquakes to constructions may be greater than in other areas. In particular, the districts of Lázaro Cárdenas, Benito Juárez, Cuauhtémoc, Emiliano Zapata, Las Mesas, Buenos Aires, Lomas del Quebrachal, and Lomas del Riscal would be affected. In general, houses vulnerable to the impact of earthquakes are in regions where the population is socially more vulnerable. More than 50% of the population and 30% of the houses have high and very high level of social and structural vulnerability, respectively. Our results provide information to the local and federal authorities to strengthen their civil protection and mitigation plans.
Digital product passports as enablers of digital circular economy: a framework based on technological perspective
Authors: Voulgaridis Konstantinos , Lagkas Thomas , Angelopoulos Constantinos Marios , Boulogeorgos Alexandros-Apostolos A. , Argyriou Vasileios , Sarigiannidis Panagiotis 
Published: January 2024

AbstractTaking into consideration the existing Industry 4.0 infrastructures and the rise of Industry 5.0 (I5.0), more and more solutions are being developed, aiming towards increased environmental consciousness through advanced technologies, and human centricity. However, there are ongoing requirements on data traceability, and access to the related actors, to ensure the establishment of sustainable solutions, within the context of a digital circular economy (DCE) environment. Digital product passports (DPPs) constitute such novel technological solution that can enable the transition toward DCE and sustainable I4.0 and I5.0, as digital identities that are assigned to physical products, capable of tracing their lifecycles through data such as their technical specifications, usage instructions, and repair and maintenance information. Although the respective research community has started providing a thorough analysis of DPPs potential to constitute a CE enabler, their technical requirements are still unclear. As part of our contribution to this issue, we propose a fundamental CE framework with integrated DPP characteristics, with the potential of being adapted in different sector stages for the generation and distribution of DPPs both for stakeholders and consumers. The corresponding solution is further supported through a systematic literature review that follows a technological approach to the DPPs implementation.
A Novel Strategic Water Loss Management Model and Its Optimization with Harris Hawk Algorithm
Authors: Bozkurt Cansu , Ates Abdullah , Fırat Mahmut , Yılmaz Salih , Özdemir Özgür 
Published: January 2024

AbstractWater loss management (WLM) in water distribution systems (WDSs) is generally time consuming, costly and difficult. Therefore, the most appropriate methodology should be defined based on the current status, requirements and technical capacity of the utilities. In this study, a novel WLM model was developed to improve the WLM practices, to define the most appropriate and applicable targets and to determine the components that need to be improved primarily using the Harris Hawk Optimization (HHO) algorithm. Firstly, a total of 144 components in the CSAS proposed by Bozkurt et al. (Welcome Sigma J Eng Natural Sci 40:1–13, 2022b) are scored in three utilities. The averages of current scores in utilities are 3.4167, 2.9792 and 1.1597, respectively. Then the most appropriate targets were defined with the optimization algorithm by considering the current situation and the dynamic structure of utility. The target scores defined by optimization model in utilities are 4.4097, 4.3958 and 3.2292, respectively. This novel model will contribute to the prevention of time-consuming and costly processes by determining the most appropriate progress. It is thought that this study will provide significant benefits for creating a road map for practitioners in WLM.
EPR Monitoring of Oxygenation Levels in Tumors After Chlorophyllide-Based Photodynamic Therapy May Allow for Early Prediction of Treatment Outcome
Authors: Szczygieł Małgorzata , Kalinowska Barbara , Szczygieł Dariusz , Krzykawska-Serda Martyna , Fiedor Leszek , Murzyn Aleksandra Anna , Sopel Justyna , Matuszak Zenon , Elas Martyna 
Published: January 2024

Abstract
Purpose
Molecular oxygen, besides a photosensitizer and light of appropriate wavelength, is one of the three factors necessary for photodynamic therapy (PDT). In tumor tissue, PDT leads to the killing of tumor cells, destruction of endothelial cells and vasculature collapse, and the induction of strong immune responses. All these effects may influence the oxygenation levels, but it is the vasculature changes that have the main impact on pO2. The purpose of our study was to monitor changes in tumor oxygenation after PDT and explore its significance for predicting long-term treatment response.

Procedures
Electron paramagnetic resonance (EPR) spectroscopy enables direct, quantitative, and sequential measurements of partial pressure of oxygen (pO2) in the same animal. The levels of chlorophyll derived photosensitizers in tumor tissue were determined by transdermal emission measurements.

Results
The noninvasive monitoring of pO2 in the tumor tissue after PDT showed that the higher ΔpO2 (pO2 after PDT minus pO2 before PDT), the greater the inhibition of tumor growth. ΔpO2 also correlated with higher levels of the photosensitizers in the tumor and with the occurrence of a severe edema/erythema after PDT.

Conclusion
Monitoring of PDT-induced changes in tumor oxygenation is a valuable prognostic factor and could be also used to identify potentially resistant tumors, which is important in predicting long-term treatment response.
Forensically relevant anatomical brain regions cannot be sub-differentiated by RNA expression analysis
Authors: Euteneuer Jan , Moitinho-Silva Lucas , Courts Cornelius 
Published: January 2024

Abstract
The contextualization of biological traces generated by severe head injuries can be beneficial for criminal investigations. Here we aimed to identify and validate mRNA candidates for a robust sub-differentiation of forensically and traumatologically relevant brain regions. To this purpose, massively parallel sequencing of whole transcriptomes in sample material taken from four different areas of the cerebral cortex (frontal, temporal, parietal, occipital lobe) was performed, followed by bioinformatical data analysis, classification, and biostatistical candidate selection. Candidates were evaluated by Multiplex-RT-PCR and capillary electrophoresis. Only a weak relative upregulation and solely for candidates expressed in the parietal lobe was observed. Two candidates with upregulation in the cerebellar region (PVALB and CDR2L) were chosen for further investigation; however, PVALB could not reliably and repeatedly be detected in any lobe whereas CDR2L was detectable in all lobes. Consequently, we suggest that differences in mRNA expression between four regions of the cerebral cortex are too small and less pronounced to be useful for and applicable in forensic RNA analysis. We conclude that sub-differentiation of these brain regions via RNA expression analysis is generally not feasible within a forensic scope.
Elevation Changes in Restored Marshes at Poplar Island, Chesapeake Bay, MD: I. Trends and Drivers of Spatial Variability
Authors: Staver Lorie W. , Morris James T. , Cornwell Jeffrey C. , Stevenson J. Court , Nardin William , Hensel Philippe , Owens Michael S. , Schwark Amanda 
Published: January 2024

AbstractTidal marshes provide numerous ecosystem services, but are threatened by recent increases in global sea level rise (SLR). Marsh restoration and creation are important strategies for mitigating marsh loss, restoring ecosystem services, increasing coastal community resilience, and providing much needed habitat for threatened species. Dredged material resulting from navigation channel maintenance can provide a substrate for these restoration projects. Few studies, however, have addressed the sustainability of these marshes. The Paul S. Sarbanes Ecosystem Restoration Project at Poplar Island, where fine-grained, nutrient-rich dredged material from upper Chesapeake Bay is being used to create > 302 ha of tidal marshes, provides a case study. The low supply of inorganic sediment is counteracted by abundant nutrients, stimulating high rates of organic matter production and elevation change. Using > 10 years of data from 39 surface elevation tables, we found that the mean low marsh rate of elevation change (7.7 ± 3.21 mm year−1) was double the mean high marsh rate (3.6 ± 0.47 mm year−1) and exceeded the natural reference marsh (3.0 ± 2.28 mm year−1) and relative SLR (5.7 mm year−1). By stimulating organic matter production, the high nutrient substrate appears to offset the low inorganic sediment inputs in mid-Chesapeake Bay. Spatial variability was correlated with initial elevation, but was also influenced by local factors that may affect sediment redistribution within the marshes.
Comparison of fatigue test results of high-strength steel DED-Arc specimens with milled and unmilled surfaces
Authors: Müller Johanna , Dastgerdi Jairan Nafar , Hensel Jonas 
Published: January 2024

Abstract
The surface characteristics of direct energy deposition (DED)-Arc specimens have been previously explored, revealing the dual effect of the surface topography on fatigue strength. This effect includes a reduction in the nominal load-bearing cross-section due to the waviness of the surface and the initiation of fatigue cracks at combined geometric and metallurgical notches from the surface. To complement these findings, this study focuses on the fatigue life and crack initiation of milled DED-Arc samples, e.g., after removal of the geometric notches. Fatigue tests on DED-Arc specimens validate the impact of surface topography on fatigue strength, emphasizing the significance of surface characteristics in determining structural integrity. The additional tests conducted on milled surfaces provide insights into the failure mechanisms specific to these samples. Fracture surface analysis, microstructure characterization, and hardness measurements are performed. For both surface conditions, cracks originate in the interlayer zone, where local hardness is reduced. In unmilled specimens, this is due to the stress concentration effect, and in milled samples, this is due to softened interlayer zones. The fatigue life of milled specimens is comparatively high, demonstrating the importance of optimizing surface characteristics for improved fatigue resistance.

Highlights
1. Both, unmilled and milled specimens, show crack origins in the interlayer areas. For unmilled specimens, this is because of the local stress concentration in the notch; for milled specimens, it was shown that soft zones between the layers act as the weakest link.
2. The fatigue strength of unmilled test coupons is significantly lower than those of milled specimens.
3. Unmilled samples exhibit multiple crack origins.