bluuebunny/crossref_metadata_2025_split huggingface dataset:
Approach to multidrug resistant infections in pediatric transplant recipients
Authors: Dong Sara W. , Sharma Tanvi S. , Sue Paul K. 
Published: December 2023

IntroductionThere is increasing recognition of infections due to multidrug-resistant Gram negative (MDRGN) bacterial infections among children undergoing solid organ and hematopoietic cell transplantation, which may be associated with morbidity and mortality.MethodsWe present two vignettes that highlight the clinical challenges of evaluation, management, and prevention of MDRGN bacterial infections in children prior to and after transplantation. The goal of this discussion is to provide a framework to help develop an approach to evaluation and management of these infections.ResultsSource control remains the utmost priority in management of MDR infections and is paired with antibiotic selection guided by in vitro susceptibilities, adverse effect profiles, and clinical response. Identification and confirmation of resistance can be challenging and often requires additional testing for recognition of complex mechanisms. Current antimicrobial approaches to MDRGN infections include use of novel agents, prolonged infusion, and/or combination therapy. We also discuss preventative efforts including infection control, antimicrobial stewardship, targeted pre-emptive or prophylactic treatment, and decolonization.DiscussionThe impact of MDRGN infections on patient and graft survival highlights the need to optimize treatment and prevention strategies.
A prospective observational study of nurses performing minimally invasive tissue sampling of brain, liver, and lung tissues among deceased neonates and stillbirths in Ethiopia
Authors: Muhe Lulu Mussa , Paganelli Christina R. , Ayele Rahell Hailu , Desta Tigist , Mekasha Amha , Demtse Asrat , Awoke Tesfamichael , Elfu Teferi , Gebremariam Tewodros Yalew , Tamrat Dagnachew , Jiffar Amanuel Damie , Zenabu Aklilu Mekasha , Sori Moti , Parlberg Lindsay , Worku Alemayehu , Nigussie Assaye Kassie 
Published: December 2023

BackgroundWith a neonatal mortality rate of 33 per 1,000 live births in 2019, Ethiopia is striving to attain the Sustainable Development Goal target of 12 deaths per 1,000 live births by 2030. A better understanding of the major causes of neonatal mortality is needed to effectively design and implement interventions to achieve this goal. Minimally Invasive Tissue Sampling (MITS), an alternative to conventional autopsy, requires fewer resources and through task-shifting of sample collection from pathologists to nurses, has the potential to support the expansion of pathology-based post-mortem examination and improve mortality data. This paper evaluates the accuracy and adequacy of MITS performed by nurses at a tertiary and general hospital and in the home of the deceased.MethodsNurses in a tertiary and general hospital in Ethiopia were trained in MITS sample collection on neonatal deaths and stillbirths using standardized protocols. MITS sample collection was performed by both pathologists and nurses in the tertiary hospital and by nurses in the general hospital and home-setting. Agreement in the performance of MITS between pathologists and nurses was calculated for samples collected at the tertiary hospital. Samples collected by nurses in the general hospital and home-setting were evaluated for technical adequacy using preestablished criteria.ResultsOne hundred thirty-nine MITS were done: 125 in hospitals and 14 inside homes. There was a perfect or almost perfect agreement between the pathologists and the nurses in the tertiary hospital using Gwet's agreement interpretation criteria. The adequacy of MITS samples collected by nurses in the general hospital was more than 72% when compared to the preset criteria. The adequacy of the MITS sampling yield ranged from 87% to 91% on liveborn neonatal deaths and 76% for the liver, right and left lungs and 55% for brain tissues in stillbirths.ConclusionsThis study demonstrated that task-shifting MITS sample collection to nurses can be achieved with comparable accuracy and adequacy as pathologists. Our study showed that with standardized training and supportive supervision MITS sample collection can be conducted by nurses in a tertiary, general hospital and, at the home of the deceased. Future studies should validate and expand on this work by evaluating task-shifting of MITS sample collection to nurses within community settings and with larger sample sizes.
Long-term detoxification of opioid use disorder with opium tincture assisted treatment
Authors: Omidvar Tehrani Sahar , Rezaei Ardani Amir , Akhlaghi Saeed , Shayesteh Zarrin Masood , Talaei Ali 
Published: December 2023

IntroductionRetention in treatment, craving, and relapse rate are important indicators of the success rate in addiction maintenance therapy as they evaluate the effectiveness of the therapy and make necessary adjustments to the treatment plan. However, the rate of continuation in the treatment process and the rate of craving in patients with opioid use disorder undergoing maintenance treatment with opium tincture have not been studied. The present study aimed to investigate the rate of relapse, craving, and psychiatric disorders in patients with opioid use disorder undergoing treatment of gradual detoxification with opium tincture.MethodsNinety patients with opioid use disorder who underwent treatment with the gradual detoxification method using opium tincture in the form of Congress 60 for 11 months were enrolled in the study. The level of craving based on the Desire for Drug Questionnaire (DDQ) and patients’ self-report of drug use, the level of anxiety, depression, and sleep quality of patients were evaluated using the Beck Anxiety Inventory (BAI), Beck Depression Inventory (BDI), and Pittsburgh Sleep Quality Index (PSQI), respectively. Also, suicidal thoughts were assessed by Beck Scale for Suicidal Ideation and quality of life by the World Health Organization Quality of Life Questionnaire (WHOQOL-BREF).ResultsThe study found that the treatment resulted in a relapse rate of 16.7% for relapse. We also found that all sub-scales of the desire for drug questionnaire (DDQ), depression, and anxiety were significantly lower at the end of the study compared to its beginning. Additionally, quality of life and sleep significantly increased at the end of the study. All areas of craving, anxiety, and depression significantly decreased in all follow-up sessions that took place 1, 5, and 11 months after the start of treatment. Moreover, sleep disorders were improved considerably at the end of the treatment.ConclusionThe current study presented a low relapse rate of Iranian patients with opioid use disorder under structured treatment of gradual detoxification with opium tincture in a one-year follow-up period. Opium tincture under the Congress 60 protocol may help to control carving, decrease psychological disorders, improve quality of life, and consequently, lower relapse rate.
Methicillin resistant Staphylococcus aureus in the United Arab Emirates: a 12-year retrospective analysis of evolving trends
Authors: Thomsen Jens , Abdulrazzaq Najiba M. ,   The UAE AMR Surveillance Consortium, Menezes Godfred Antony , Ayoub Moubareck Carole , Everett Dean B. , Senok Abiola 
Published: December 2023

IntroductionMethicillin resistant Staphylococcus aureus (MRSA) is a major contributor to the global burden of antimicrobial resistance (AMR). As MRSA continues to evolve, the need for continued surveillance to evaluate trends remains crucial. This study was carried out to assess MRSA trends in the United Arab Emirates (UAE) based on analysis of data from the national AMR surveillance program.MethodsWe carried out a 12-year (2010–2021) retrospective analysis of MRSA demographic and microbiological data collected as part of the UAE national AMR surveillance program. Participating centers from across the country routinely submit AMR surveillance data collected by trained personnel to the National AMR Surveillance Committee, where data is analyzed using a unified WHONET platform. Data on non-duplicate isolates associated with clinical infections were obtained and included in the analysis.ResultsA total of 29,414 non-duplicate MRSA isolates associated with clinical infections were reported between 2010 and 2021 (2010: n = 259; 2021: n = 4,996). MRSA represented 26.4% of all S. aureus (n = 111,623) isolates identified during the study period. In 2010, among the S. aureus isolates with reported oxacillin testing, 21.9% (n/N = 259/1,181) were identified as MRSA and this showed an increase to 33.5% (n/N = 4,996/14,925) in 2021. Although there was variation in the distribution of MRSA across the seven emirates of the country, most had an upward trend. Patient demographics reflected a male preponderance, with most being adults and from the outpatient setting. Isolates were mostly from skin and soft tissue infection specimens (72.5%; n/N = 21,335/29,414). Among the inpatients (N = 8,282), a total of 3,313 MRSA isolates were from specimens obtained ≤ 48 h after admission indicative of community acquired infection. Increasing resistance trends were observed for most antibiotics including ciprofloxacin, levofloxacin, moxifloxacin, erythromycin, gentamicin, trimethoprim-sulfamethoxazole, and quinupristin/dalfopristin. Low levels of resistance (0.0–0.8%) were sustained for linezolid except for 2015, 2016, and 2017 with 2.5, 2.6, and 2.9%, respectively. No confirmed vancomycin resistance was reported.ConclusionThe increasing trend of MRSA isolates associated with clinical infections in the hospital and community settings is a concern. Continued monitoring including incorporation of genomic surveillance and infection control measures are recommended to stem the dissemination.
Anxiety prevalence and associated factors among frontline nurses following the COVID-19 pandemic: a large-scale cross-sectional study
Authors: Wang Shitao , Luo Guoshuai , Pan Dongsheng , Ding XiangQian , Yang Fei , Zhu Liping , Wang Shuo , Ma Xuelu 
Published: December 2023

IntroductionNurses are more likely to experience anxiety following the coronavirus 2019 epidemic. Anxiety could compromise nurses’ work efficiency and diminish their professional commitment. This study aims to investigate nurses’ anxiety prevalence and related factors following the pandemic in multiple hospitals across China.MethodsAn online survey was conducted from April 16 to July 3, 2023, targeting frontline nurses who had actively participated in China. Anxiety and depression symptoms were assessed using the Self-rating Anxiety Scale and the Self-rating Depression Scale (SDS), respectively. Multivariable logistic regression analysis was employed to identify factors linked with anxiety.ResultsA total of 2,210 frontline nurses participated in the study. Overall, 65.07% of participants displayed clinically significant anxiety symptoms. Multivariable logistic regression revealed that nurses living with their families [2.52(95% CI: 1.68–3.77)] and those with higher SDS scores [1.26(95% CI: 1.24–1.29)] faced an elevated risk of anxiety. Conversely, female nurses [0.02(95% CI: 0.00–0.90)] and those who had recovered from infection [0.05(95%CI: 0.07–0.18)] demonstrated lower rates of anxiety.DiscussionThis study highlights the association between SDS score, gender, virus infection, living arrangements and anxiety. Frontline nurses need to be provided with emotional support to prevent anxiety. These insights can guide interventions to protect the mental well-being of frontline nurses in the post-pandemic period.
GERAKAN SAYANG LANSIA PADA MASA PANDEMIK COVID-19 DI DESA KERTAWANGI KABUPATEN BANDUNG BARAT
Authors: Kusniasih Susi , Lestari Febri Sri 
Published: December 2023

Gerakan Sayang Lansia (GSL) merupakan satu program pemerintah untuk menyadarkan masyarakat akan peran lansia sehingga perlu menjaga keseimbangan kehidupan lansia. Ada tiga faktor yang dapat menjaga keseimbangan lansia dalam keluarga di era new normal ini, yakni faktor biologi dengan memenuhi kebutuhan fisik lansia dengan meningkatkan daya tahan tubuh, faktor psikologis dengan memenuhi kebutuhan mental lansia untuk disayangi dan dilindungi, serta faktor sosial budaya dengan memberikan sikap dan perilaku yang membuat lansia dihormati dalam keluarga. Target program kemitraan wilayah ini adalah kader, sedangkan luarannya adalah meningkatnya pengetahuan dan keterampilan kader. Metode yang dilaksanakan pelatihan kader diawali pre test, pemberian materi tentang Gerakan Sayang Lansia, pendampingan kader dan diakhiri post test. Hasil akhir kader posyandu, khususnya di Desa Kertawangi, adanya peningkatan pengetahuan kader kesehatan mengenai kebutuhan fisik lansia dengan meningkatkan daya tahan tubuh melalui pendidikan kesehatan tentang kebutuhan gizi lansia senam lansia, teknik mencuci tangan yang baik pada lansia, dan penggunaan masker pada lansia; ketenangan psikologis lansia; kehidupan lansia dalam sosial budaya melalui penyuluhan tentang pentingnya sikap dan perilaku yang membuat lansia dihormati dalam keluarga.
PENYULUHAN DAN EDUKASI PENYAKIT INFEKSIUS HIV/AIDS DI STIT DARUL FATAH BANDAR LAMPUNG
Authors: HARTANTI HARTANTI , Dinutanayo Wimba Widaghdo , Amien A. Zakaria , Djayasinga Rodhiansyah 
Published: December 2023

Perilaku remaja dalam mencegah HIV/AIDS akan sangat dipengaruhi oleh pengetahuan dan sikap remaja terhadap HIV/AIDS. Menindaklanjuti hal tersebut, maka perlu dilaksanakan upaya peningkatan pengetahuan remaja tentang HIV/AIDS melalui kegiatan penyuluhan. Kegiatan penyuluhan dan edukasi ini nantinya diharapkan dapat meningkatkan sikap dan perilaku mencegah penularan HIV/AIDS. Tujuan kegiatan ini adalah melaksanakan penyuluhan dan edukasi mengenai penyakit infeksius HIV/AIDS kepada mahasisa STIT Darul Fatah, Bandar Lampung sebagai upaya pencegahan infeksi dan penularan HIV/AIDS. Kegiatan ini dilakukan dengan metode penyuluhan, edukasi, dan diskusi tentang pengertian, cara penularan, cara pencegahan, pemeriksaan, pengobatan dan perawatan Orang dengan HIV/AIDS (ODHA). Waktu pelaksanaan yaitu Kamis, 09 Juni 2022, bertempat di Kampus STIT Darul Fatah, Jl. Kopi No. 23A, Gedung Meneng, Bandar Lampung. Kegiatan diikuti oleh 30 mahasiswa semester 2. Evaluasi luaran kegiatan di lakukan melalui pemberian pre-test dan post-test berupa kuisioner mengenai penyakit HIV/AIDS. Hasil kuisioner menunjukkan bahwa ada peningkatan pengetahuan tentang HIV dan AIDS dari hasil pre-test dan post-test
PENINGKATAN GERAKAN PSN DAN APLIKASI LARVASIDA NABATI DALAM MENGENDALIKAN JENTIK Aedes aegypti DI RW.12 KELURAHAN PASIRKALIKI KECAMATAN CIMAHI UTARA
Authors: Hidayah Nurul , Wahyudin Dindin 
Published: December 2023

Data kasus Demam Darah Dengue (DBD) di Kelurahan Pasirkaliki dari tahun 2019 sampai tahun 2022 semakin meningkat yaitu ada 45.387 kasus. Penyakit DBD ditularkan melalui vektor nyamuk Aedes aegypti yang membawa virus dengue. Pengendalian vektor nyamuk Aedes aegypti dapat dilakukan mulai dari pemberantasan jentik atau larvanya sebelum berkembang menjadi nyamuk dewasa. Berdasarkan hasil survei jentik Aedes aegypti di RW 12 Kelurahan Pasirkaliki yang dilakukan oleh Puskesmas Pasirkaliki bekerjasama dengan mahasiswa jurusan Kesehatan Lingkungan diketahui angka bebas jentik di RT 03 sebesar 14,28% dan di RT 01 sebesar 21,42%, ini menunjukan sangat rendah dibandingkan dengan standar dari pemerintah yaitu >95%. Penggunaan larvasida nabati ramah lingkungan yang berbahan dasar bahan-bahan alami seperti sereh, jahe dan daun mimba mampu mengendalikan jentik ataupun nyamukAedes aegypti. Tujuan pengabdian masyarakat ini untuk meningkatkan penahaman mengenai penyakit DBD, cara pengendaliannya, melaksanakan dan mengevaluasi upaya meningkatkan Angka Bebas Jentik (ABJ), serta mengaplikasikan penggunaan larvasida nabati. Metode pelaksanaan kegiatan melalui sosialisasi pemahaman melalui pre-post tes mengenai penyakit DBD dan pengendaliannya, observasi untuk mengetahui angka bebas jentik (ABJ)dan pengaplikasian teknologi tepat guna yaitu penggunaan larvasida nabati kepada kader RT 01 dan RT 03. Hasil kegiatan menunjukan adanya rerata peningkatan pengetahuan responden pre-post yaitu RT 01 pre 45% post 68,5%, RT 03 pre 55,2% post 70,5%. Ada peningkatan rerata Angka Bebas Jentik sebelum dan setelah dilakukan pembinaan PSN, yaitu 89,88% di RT.01 dan 94,89% di RT.03 RW.12, serta masyarakat mampu mengaplikasikan larvasida nabati berasal dari bahan-bahan alami yang ada di lingkungan sekitar masyarakat.
SOSIALISASI PENTINGNYA KOMUNIKASI ANTAR PETUGAS KESEHATAN AGAR TERCAPAINYA KOMUNIKASI EFEKTIF DI RUMAH SAKIT UMUM DELIA KABUPATEN LANGKAT
Authors: Rangkuti Dyna Safitri Rakhelmi , Mentari Tarigan Andini 
Published: December 2023

Peningkatan mutu pelayanan merupakan prioritas utama di semua rumah sakit. Upaya tersebut dilaksanakan melalui pembangunan sarana, prasarana, pengadaan peralatan dan ketenagaan serta perangkat lunak lainnya, sejalan dengan pembangunan rumah sakit pada umumnya. Namun demikian, disadari pula masih banyak kendala yang dihadapi, terutama yang berkaitan dengan standar kebutuhan dan tuntutan system pelayanan yang masih belum selaras dengan perkembangan IPTEK kedokteran yang semakin pesat dimana pelayanan spesialis dan subspesialis cenderung semakin berkembang. Dengan semakin meningkatnya tuntutan masyarakat akan mutu pelayanan tadi maka fungsi pelayanan kesehatan termasuk pelayanan dalam rumah sakit secara bertahap perlu terus ditingkatkan agar menjadi lebih efektif dan efisien serta member kepuasan terhadap pasien, keluarga maupun masyarakat. Keselamatan Pasien adalah suatu sistem dimana rumah sakit membuat asuhan pasien lebih aman, meliputi asesmen risiko, identifikasi dan pengelolaan risiko pasien, pelaporan dan analisis insiden, kemampuan belajar dari insiden dan tindak lanjutnya, serta implementasi solusi untuk meminimalkan timbulnya risiko dan mencegah terjadinya cedera yang disebabkan oleh kesalahan akibat melaksanakan suatu tindakan atau tidak mengambil tindakan yang seharusnya diambil. Metode pendekatan yang digunakan adalah ceramah dan tanya jawab /informasi/edukasi, diskusi dan bimbingan teknik. Melalui kegiatan pengabdian masyarakat ini juga para peserta khususnya yang berkaitan dengan PMKP (Peningkatan Mutu dan Keselamatan Pasien) lebih paham mengenai mengenai pentingnya terlebih ketika ada kegiatan akreditasi Rumah Sakit karena banyak yang belum paham mengenai PMPK ini. Adanya penambahan pengetahuan mengenai PMKP ini agar ketika dilakukannya akreditasi PMKP ini menjadi pusat perhatian karena telah dilaksanakan dengan baik dan benar.
UJI KADAR VITAMIN C DAN AKTIVITAS ANTIOKSIDAN DARI FRAKSI KULIT BUAH MELINJO (Gnetum gnemon L)
Authors: Ibrahim Kevvy Buana , Wardana Fendi Yoga , Prasetiyo Bagus Dadang , Puspitasari Meyrika Dwi 
Published: December 2023

Melinjo (Gnetum gnemon L) di Indonesia banyak dimanfaatkan sebagai bahan pangan namun kulit buah melinjo sendiri dianggap limbah karena belum ada upaya pemanfaatannya secara maksimal dan belum ada penelitian mengenai detail kandungan senyawa aktif yang ada di dalamnya. Kulit buah melinjo diduga dapat berpotensi menjadi sumber vitamin C dan antioksidan alami yang dapat menekan aktivitas dari radikal bebas. Tujuan penelitian mengetahui kadar vitamin C dan aktivitas antioksidan dari fraksi kulit buah melinjo. Dilaksanakan pada Agustus hingga September 2023 di Laboratorium Farmakognosi dan Kimia ITSK RS DR. Soepraoen. Ekstraksi menggunakan metode maserasi dilanjutkan fraksinasi. Penentuan kadar vitamin C menggunakan spektrofotometri UV-Vis, sedangkan penentuan aktivitas antioksidan dengan metode DPPH. Hasil kadar vitamin C tertinggi sebesar 7,3483 μg/mL pada fraksi etanol, diikuti etil asetat 7,0285 μg/mL dan n-heksan 3,6108 μg/mL. Hasil aktivitas antioksidan dengan nilai IC50 tertinggi sebesar 279,35 μg/mL pada fraksi etil asetat, diikuti etanol 333,98 μg/mL, dan n-heksan 4077,31 μg/mL. Pelarut dengan kepolaran lebih tinggi mampu mengekstrak senyawa vitamin C dari simplisia lebih efisien dan pelarut yang bersifat semi polar mampu lebih efektif menarik senyawa yang memiliki aktivitas antioksidan, jenis kepolaran dari sebuah pelarut mampu mempengaruhi jumlah serta jenis senyawa yang akan diekstraksi sesuai dengan kepolaran dari senyawa tersebut. Direkomendasikan pada penelitian selanjutnya menguji senyawa aktif antioksidan fraksi etil asetat dan metode lain pengujian aktivitas antioksidan kulit buah melinjo.
PELATIHAN PENYUSUNAN LAPORAN KEUANGAN BAGI KELOMPOK PKK KECAMATAN KAPUAS KABUPATEN SANGGAU
Authors: PRATIWI Nia , Nugroho Yohanes Adi , Saputra Edi , Sastrawan Rahman , Hendreo Chornolius , Toliang Ermina , Ilham Syarif Muhammad , Maulana Arief Rio 
Published: December 2023

The community service activity was initiated by the Accounting Department's PPM team after coordinating with the head of the PKK (Family Welfare Empowerment Program) team in the Kapuas sub-district of Sanggau Regency in August 2023. The coordination and survey results with the head of the PKK team revealed that there had been no previous involvement of the Community Service (PPM) team from the Accounting D-3 Study Program at the PSDKU POLNEP Campus in Sanggau Regency, providing financial report training to the PKK group in the Kapuas sub-district of Sanggau Regency. The PKK group also demonstrated a lack of understanding in the field of accounting and financial reporting. Their level of understanding regarding accounting and financial reports was low, making it difficult for village and neighborhood leaders to compile and explain these financial reports. The solution proposed by the Accounting Department's PPM team to address the issues faced by their partners was to conduct financial report training for the PKK group in the Kapuas sub-district of Sanggau Regency. Through this training, the PKK group would be equipped with knowledge and skills in accounting and financial reporting, particularly in the preparation of financial reports. After identifying the partner's problems, the Accounting Department's PPM team prepared a module for financial report preparation, conducted the training, provided assistance, evaluated the process, and prepared activity implementation reports in the form of a proposal, progress report, and final PPM report. This training took place on Monday, September 11, 2023, at the Kapuas sub-district office hall in Sanggau Regency, with 62 participants from the PKK groups.
The training activity went smoothly and was executed as intended, starting at 8:00 AM until completion. Consequently, this training could assist the PKK groups in enhancing their understanding of accounting record-keeping and the accounting processes in preparing financial reports. This activity resulted in mandatory outputs published in an article in the Pontianak Post newspaper on Wednesday, September 13, 2023.

Keywords: Accounting, Financial Reporting, PKK Group