bluuebunny/crossref_metadata_2025_split huggingface dataset:
Patient and physician decision‐making dynamics in overactive bladder care: A mixed methods study
Authors: Sitto Hannah M. , Brodsky Casey N. , Wittmann Daniela , Wallner Lauren P. , Streur Courtney , DeJonckheere Melissa , Stoffel John S. , Cameron Anne P. , Sarma Aruna , Quentin Clemens James , Ippolito Giulia M. 
Published: February 2024

AbstractAimsOveractive bladder management includes multiple therapeutic options with comparable efficacy but a range of administration modalities and side effects, creating an ideal setting for shared decision‐making. This study investigates patient and physician health beliefs surrounding decision‐making and expectations for overactive bladder with the aim of better understanding and ultimately improving decision‐making in overactive bladder care.MethodsPatient and physician participants completed a questionnaire followed by a semi‐structured interview to assess health beliefs surrounding decision making and expectations for overactive bladder treatment. The semi‐structured interview guide, developed in an iterative fashion by the authors, probed qualities of overactive bladder therapies patients and physicians valued, their process of treatment selection, and their experiences with therapies.ResultsPatients (n = 20) frequently cited treatment invasiveness, efficacy, and safety as the most important qualities that influenced their decision when selecting overactive bladder therapy. Physicians (n = 12) frequently cited safety/contraindications, convenience, cost/insurance, and patient preference as the most important qualities. In our integration analysis, we identified four key themes associated with decision making in overactive bladder care: frustration with inaccessibility of overactive bladder treatments, discordant perception of patient education, diverging acceptability of expected outcomes, and lack of insight into other parties' decisional priorities and control preferences.ConclusionsWhile both patients and physicians desire to engage in a shared decision‐making process when selecting therapies for overactive bladder, this process is challenged by significant divergence between patient and physician viewpoint across key domains.
Asynchronous ADMM for nonlinear continuous‐time systems
Authors: Pierer von Esch Maximilian , Völz Andreas , Graichen Knut 
Published: February 2024

AbstractThis paper presents synchronous as well as asynchronous formulations of the alternating direction method of multipliers (ADMM) for solving continuous‐time nonlinear distributed model predictive control (DMPC) problems. It is shown that the optimal control problems of certain system classes can be transformed to fit the consensus‐based ADMM variant problem formulation. The arising subproblems are solved locally on the agent level while the consensus step is solved centrally by a coordinator. Furthermore, the convergence of the synchronous and asynchronous ADMM algorithms to their respective first‐order optimality conditions is presented in a continuous‐time setting. The algorithm is applied to different example systems for which the convergence behavior and influence of the individual algorithmic parameters are investigated. The computation time of the agents remains unaffected by the system size and thus demonstrates the applicability to high‐scaled systems. Moreover, results show that the asynchronous algorithm performs better in terms of execution time when compared to its synchronous counterpart.
Assessing the degradation profiles of a thermoresponsive polyvinyl alcohol (PVA)‐based hydrogel for biomedical applications
Authors: Abbondandolo Antonio G. , Brewer Erik C. 
Published: February 2024

AbstractPrimary challenges associated with the design and success of polymeric biomedical devices are generally related to the control of the biomaterial in terms of degradability characteristics, sufficient processability characteristics, and required mechanical strength that may be altered during sterilization or manufacturing procedures. Polyvinyl alcohol‐based thermoresponsive biomaterials provide a distinct advantage for biomedical applications as their physiochemical properties can be easily modified according to their desired use. In this work, we evaluated the thermal degradation characteristics of a polyvinyl alcohol (PVA)/polyethylene glycol (PEG)/polyvinylpyrrolidone (PVP) hydrogel that undergoes a steam sterilization autoclave cycle at 121°C to induce fluid‐like behavior. FTIR was used to characterize the evolution of the area of the carbonyl region between 1800 and 1525 cm−1. The carbonyl area increased at temperatures beyond 121°C which were used to accelerate the onset of degradation during both thermal oxidation and pyrolysis. The change in the carbonyl region was shown to correlate with respect to both temperature and time of exposure. The carbonyl region increased significantly in the presence of oxygen at temperatures above 150°C. Despite showing signs of thermal degradation at temperatures exceeding 150°C, our biomaterial was shown to be stable at 121°C during thermal degradation testing. Furthermore, bulk property analysis showed the hydrogel's mechanical and swelling properties were preserved even after being subject to multiple autoclave cycles beyond what would be experienced during a sterilization or clinical procedure.
Impact of polymeric films and hydrogels: Physical characteristics on bacterial growth
Authors: Techakasikornpanich Mongkol , Jangpatarapongsa Kulachart , Polpanich Duangporn , Elaissari Abdelhamid 
Published: February 2024

AbstractHydrogels find diverse applications in manipulating bacteria, and serving purposes like elevation, maintenance, and elimination. Several factors of hydrogel have been studied in the benefits of antibacterial activity. Factors such as hydrogel stiffness and roughness gain significance in surface coating, influencing bacterial behavior. However, the intricate interplay of hydrogel stiffness, roughness, polymer types, and bacterial species necessitates further exploration. The choice of polymer is dictated by the specific objectives, particularly in antibacterial scenarios where polymers with positive charge, hydrophilicity, and acidity prove effective. These properties induce robust electrostatic and hydrophobic/hydrophilic interactions, along with pH‐induced cell membrane damage, collectively contributing to hindered bacterial adhesion and growth. Additionally, extracellular polymeric substances (EPS) emerge as pivotal influencers in bacterial adhesion and proliferation. EPS production alters bacterial surfaces, fostering connections between bacteria and facilitating biofilm formation. The hydrophobic nature of EPS further complicates bacterial interactions with surface materials, emphasizing the nuanced interplay of hydrophilic and hydrophobic forces in bacterial adhesion. Herein, this work article has reviewed the related study of each physical property related to antibacterial property on the surface of the hydrogel. Moreover, this work also illustrates applications of the antibacterial properties of hydrogel for medical and surface treatment, including wound healing, food packaging, and surface coating. Additionally, the bacteria growing on hydrogel for engineered living materials, have been updated in various applications.
Comprehensive clinicopathological, molecular, and methylation analysis of mesenchymal tumors with NTRK and other kinase gene aberrations
Authors: Klubíčková Natálie , Dermawan Josephine K , Mosaieby Elaheh , Martínek Petr , Vaněček Tomáš , Hájková Veronika , Ptáková Nikola , Grossmann Petr , Šteiner Petr , Švajdler Marián , Kinkor Zdeněk , Michalová Květoslava , Szepe Peter , Plank Lukáš , Hederová Stanislava , Kolenová Alexandra , Spasov Neofit Juriev , Kosemehmetoglu Kemal , Pažanin Leo , Špůrková Zuzana , Baník Martin , Baumruk Luděk , Meyer Anders , Kalmykova Antonina , Koshyk Olena , Michal Michal , Michal Michael 
Published: February 2024

AbstractAlterations in kinase genes such as NTRK1/2/3, RET, and BRAF underlie infantile fibrosarcoma (IFS), the emerging entity ‘NTRK‐rearranged spindle cell neoplasms’ included in the latest WHO classification, and a growing set of tumors with overlapping clinical and pathological features. In this study, we conducted a comprehensive clinicopathological and molecular analysis of 22 cases of IFS and other kinase gene‐altered spindle cell neoplasms affecting both pediatric and adult patients. Follow‐up periods for 16 patients ranged in length from 10 to 130 months (mean 38 months). Six patients were treated with targeted therapy, achieving a partial or complete response in five cases. Overall, three cases recurred and one metastasized. Eight patients were free of disease, five were alive with disease, and two patients died. All cases showed previously reported morphological patterns. Based on the cellularity and level of atypia, cases were divided into three morphological grade groups. S100 protein and CD34 were at least focally positive in 12/22 and 14/22 cases, respectively. Novel PWWP2A::RET, NUMA1::RET, ITSN1::RAF1, and CAPZA2::MET fusions, which we report herein in mesenchymal tumors for the first time, were detected by RNA sequencing. Additionally, the first uterine case with BRAF and EGFR mutations and CD34 and S100 co‐expression is described. DNA sequencing performed in 13 cases uncovered very rare additional genetic aberrations. The CNV profiles showed that high‐grade tumors demonstrate a significantly higher percentage of copy number gains and losses across the genome compared with low‐ and intermediate‐grade tumors. Unsupervised clustering of the tumors’ methylation profiles revealed that in 8/9 cases, the methylation profiles clustered with the IFS methylation class, irrespective of their clinicopathological or molecular features. © 2024 The Authors. The Journal of Pathology published by John Wiley & Sons Ltd on behalf of The Pathological Society of Great Britain and Ireland.
The confined helium atom: An information–theoretic approach
Authors: Estañón C. R. , Montgomery H. E. , Angulo J. C. , Aquino N. 
Published: February 2024

AbstractIn this article, we study the helium atom confined in a spherical impenetrable cavity by using informational measures. We use the Ritz variational method to obtain the energies and wave functions of the confined helium atom as a function of the cavity radius . As trial wave functions we use one uncorrelated function and five explicitly correlated basis sets in Hylleraas coordinates with different degrees of electronic correlation. We computed the Shannon entropy, Fisher information, Kullback–Leibler entropy, Tsallis entropy, disequilibrium and Fisher–Shannon complexity, as a function of . We found that these entropic measures are sensitive to electronic correlation and can be used to measure it. As expected these entropic measures are less sensitive to electron correlation in the strong confinement regime ( a.u.).
Leaching characteristics of electrochemically precipitated struvite compared to other common phosphorus fertilizers in differing soils
Authors: Simms Tatum , Brye Kristofor R. , Roberts Trenton L. , Greenlee Lauren F. 
Published: February 2024

AbstractPhosphate‐rich struvite (MgNH4PO4·6H2O) can be reclaimed from wastewater as a fertilizer material to help provide clean water and sustainable food production. The objective of this study was to evaluate the leaching characteristics of wastewater‐recovered electrochemically precipitated struvite (ECST) compared to other common fertilizer‐P sources in soils from Arkansas (AR loam and silt loam), Missouri (MO silt loam 1 and 2), and Nebraska (NE sandy loam and silt loam). A bench‐scale, soil‐column experiment was conducted using five fertilizer‐P sources (i.e., ECST, chemically precipitated struvite [CPST], monoammonium phosphate [MAP], triple superphosphate [TSP], and an unamended control [UC]) and leached six times over 15 weeks after fertilizer application. Leachate‐P concentration changes from the UC differed among soil–fertilizer combinations over time (p < 0.05) but only in the AR‐loam, where TSP (2.0–6.6 mg L−1) consistently had a larger leachate‐P change from the UC than ECST (−0.04 to 3.1 mg L−1) in weeks 1–3. Leachate‐NO3‐N concentration changes from the UC among soils occurred only in week 1, where three of the six soils had NO3‐N concentration increases >10.7 mg L−1 from their respective UC. Though inconsistent across the various soils evaluated, P‐leaching losses relative to respective UC treatments were often larger from MAP and TSP than ECST and CPST. Results showed that P, NH4‐N, NO3‐N, Ca, Mg, and Fe leaching potentials differed among soils depending on initial soil pH and texture and fertilizer‐P source; thus, soil characteristics and fertilizer‐P source should be considered to minimize potential nutrient leaching losses.
Personal freedom and societal expectations towards LGBTQ+: Audience insights into Vietnamese cinema's “Goodbye Mother”
Authors: Thinh Mai Phuc 
Published: February 2024

AbstractThis study examines the cinematic masterpiece “Thưa mẹ con đi” (Goodbye Mother) by Trinh Dinh Le Minh, with a specific focus on its representation of LGBTQ+ themes, love, and identity. Utilizing a multifaceted research approach, which includes an in‐depth plot overview analysis, a substantial survey involving over 300 participants, and enlightening semi‐structured interviews, the study offers profound insights into the perspectives of its audience. The findings uncover intricate perceptions regarding family expectations, acceptance, and personal freedom, illuminating the film's capacity to challenge and reshape societal norms. Ultimately, this research highlights the influential role of cinema in cultivating greater comprehension and acceptance of diverse expressions of love and identity within the context of contemporary Vietnamese society, presenting significant contributions to both LGBTQ+ and media studies.
Investigation of the Effects of 1,2,4‐Triazole and Thiazole Ring‐Containing Hybrid Molecules on Carbonic Anhydrase I and II
Authors: Camadan Yasemin , Akkemik Ebru , Güller Pınar , Ceylan Şule , Özdemir Hasan 
Published: February 2024

AbstractCarbonic anhydrase (CA, EC 4.2.1.1) is an enzyme that catalyzes the reversible reaction of carbon dioxide to bicarbonate and a proton under physiological conditions. Pharmaceutical research has gained importance since the design of novel compounds that inhibit CA I–II isoenzymes has a promising approach for pharmacological intervention in many diseases. Triazole derivatives have attracted attention due to their chemotherapeutic, antifungal, antiviral, antibiotic, analgesic, and antifungal activities. Therefore, in this study, the effect of 1,2,4‐triazole and thiazole ring‐containing compounds on human carbonic anhydrase I (hCA I) and II (hCA II) isoenzymes were investigated in vitro. For this purpose, hCA I and hCA II isoenzymes were purified by Sepharose‐4B affinity column chromatography. Estimation of inhibition mechanism and drug‐likeness characteristics of compounds were also determined using molecular docking simulation. The inhibitory effects of ten compounds were investigated. Activity vs. concentration graphs were prepared for each compound and IC50 values or AC50 were calculated from these graphs. It was revealed that some of the compounds exhibited selective inhibition on carbonic anhydrase isoenzymes. The studied compounds are considered to be drug candidates.
Sustainable Synthesis of Heteroaryl‐Ethers: Fe(III)‐Catalyzed C−H Activation under Air Using a Mild Oxidant
Authors: Chahal Kapil , Shantharjun Bangarigalla , Sankar Dev , Priyanka K. Krishna , Rajender Reddy Kallu 
Published: February 2024

AbstractA cost effective protocol has been developed for the synthesis of diverse heterocyclic ethers through the radical cross‐coupling of heteroarenes and cyclic ethers. This reaction is catalyzed by inexpensive iron(III) perchlorate and employs TBHP (tert‐butyl hydroperoxide) as an external oxidant. The protocol demonstrates remarkable versatility in substrate compatibility and can accommodate various functional groups, all under mild reaction conditions. Importantly, this method eliminates the need for costly metals and avoids photo‐redox processes, making it a promising strategy for efficient and sustainable chemical synthesis.
Self‐Templating Copolymerization to Produce Robust Conductive Nanocoatings Based on Conjugated Polymer Brushes with Implementable Memristive Characteristics
Authors: Wolski Karol , Smenda Joanna , Świerz Wojciech , Dąbczyński Paweł , Marzec Mateusz , Zapotoczny Szczepan 
Published: February 2024

AbstractAn effective synthesis of conductive polymer brushes, i.e., self‐templating surface‐initiated copolymerization (ST‐SICP), is developed. It proceeds through copolymerization of pendant thiophene groups in the precursor multimonomer poly(3‐methylthienyl methacrylate) (PMTM) brushes with free 3‐methylthiophene (3MT) monomers leading to PMTM‐co‐P3MT brushes. This approach leads to improved conformational freedom of generated conjugated poly(thiophene)‐based chains and their higher share in the brushes with respect to conjugation of pendant thiophene groups only. As a result, best performing conjugated PMTM‐co‐P3MT brushes demonstrate high ohmic conductivity in both out‐of‐plane and in‐plane direction. Furthermore, thanks to the covalent anchoring as well as intra‐ and intermolecular connections, highly stable and mechanically robust nanocoatings are produced which can survive mechanical cleaning and long‐term storage under ambient conditions. Grafting of ionic poly(sodium 4‐styrenesulfonate) (PSSNa) in between PMTM‐co‐P3MT chains brings new properties to such binary mixed brushes that can operate as thin‐film memristive coating with switchable conductance. It is worth mentioning that the crucial synthetic steps, i.e., grafting of precursor PMTM brushes by surface‐initiated organocatalyzed atom transfer radical polymerization (SI‐O‐ATRP) and PSSNa chains by surface‐initiated photoiniferter‐mediated polymerization (SI‐PIMP) are conducted under ambient conditions using only microliter volumes of reagents providing methodology that can be considered for use beyond the laboratory scale.
Building research capacity in ultrasound departments
Authors: McLean Glenda , Lewis Annie 
Published: February 2024

AbstractResearch is integral to evidence‐based practice in healthcare benefiting both the professional's knowledge and improving patient care. Despite its importance, building research capacity within ultrasound departments presents significant challenges for sonographers, managers and health services. In this commentary key factors influencing research culture and capacity building are explored, emphasising the role of the individual sonographer, organisations and structural support, in fostering a culture of research in the ultrasound department.
From graphs as task to graphs as tool
Authors: Stephens A. Lynn 
Published: February 2024

AbstractIt is widely recognized that we need to prepare students to think with data. This study investigates student interactions with digital data graphs and seeks to identify what might prompt them to shift toward using their graphs as thinking tools in the authentic activity of doing science. Drawing from video screencast data of three small groups engaged in sensor‐based and computer simulation‐based experiments in high school physics classes, exploratory qualitative methods are used to identify the student interactions with their graphs and what appeared to prompt shifts in those interactions. Analysis of the groups, one from a 9th grade class and two from 11th/12th grade combined classes, revealed that unexpected data patterns and graphical anomalies sometimes, but not always, preceded deeper engagement with the graphs. When shifts toward deeper engagement did occur, transcripts revealed that the students perceived the graphical patterns to be misaligned with the actions they had taken to produce those data. Misalignments between the physical, digital, and conceptual worlds of the investigations played an important role in these episodes, appearing to motivate students to revise either their experimental procedures or their conceptions of the phenomena being explored. If real‐time graphs can help foster a sense in students that there should be alignments between their data production and data representations, it is suggested that pedagogy leverage this as a way to support deeper student engagement with graphs.
The functional role of the pulvinar in discriminating between objective and subjective cognitive impairment in major depressive disorder
Authors: Yulug Burak , Ayyildiz Sevilay , Sayman Dila , Karaca Ramazan , Ipek Lutfiye , Cankaya Seyda , Salar Ali Behram , Ayyildiz Behcet , Mikuta Christian , Yagci Nilay , Oktem Ece Ozdemir , Ozsimsek Ahmet , Velioglu Halil Aziz , Hanoglu Lutfu 
Published: February 2024

AbstractINTRODUCTIONEmotionally driven cognitive complaints represent a major diagnostic challenge for clinicians and indicate the importance of objective confirmation of the accuracy of depressive patients’ descriptions of their cognitive symptoms.METHODSWe compared cognitive status and structural and functional brain connectivity changes in the pulvinar and hippocampus between patients with total depression and healthy controls. The depressive group was also classified as “amnestic” or “nonamnestic,” based on the members’ subjective reports concerning their forgetfulness. We then sought to determine whether these patients would differ in terms of objective neuroimaging and cognitive findings.RESULTSThe right pulvinar exhibited altered connectivity in individuals with depression with objective cognitive impairment, a finding which was not apparent in depressive patients with subjective cognitive impairment.DISCUSSIONThe pulvinar may play a role in depression‐related cognitive impairments. Connectivity network changes may differ between objective and subjective cognitive impairment in depression and may play a role in the increased risk of dementia in patients with depression.
Numerical analysis of a tethered‐buoy mooring system for a prototype floating wind farm
Authors: Liang Guodong , Wickmann Hanssen Finn‐Christian , Otto Merz Karl , Jiang Zhiyu 
Published: February 2024

AbstractConventional mooring systems contribute significantly to the cost of floating wind projects, and innovative solutions with cost‐saving potentials are desired. In the present paper, we investigate the fundamental dynamic behavior of an innovative tethered‐buoy mooring system for a prototype wind farm in which two spar floating offshore wind turbines (FOWTs) are moored to five submerged tethered buoys. Numerical decay tests are used to characterize the fundamental frequencies and oscillatory modes of the system. The influence of net buoyancy is established through a parametric study. Finally, the dynamic response of the tethered‐buoy mooring system is compared against two alternative shared mooring configurations with catenary mooring lines. Time‐domain simulations are carried out for one accidental scenario with a parked and an operational FOWT, and one extreme scenario with two parked FOWTs. The results show that net buoyancy has a significant influence on platform motions and mooring loads. Compared to alternative configurations with catenary mooring lines, the tethered‐buoy mooring system exhibits substantially lower mooring tension loads and practically eliminates the threat of snap events. The reduction in the maximum characteristic fairlead tension is up to 85%. The mean positional offset of the wind turbines in the loading direction is larger, up to 36% of the water depth, however, the relative motions are comparable. The mean distance between the FOWTs is even smaller for the tethered‐buoy system. With the application of dynamic inter‐array cables, the proposed tethered‐buoy system can be a promising mooring solution for floating offshore wind farms.