bluuebunny/crossref_metadata_2025_split huggingface dataset:
Prevalence, risk factors, and BRAF mutation of colorectal sessile serrated lesions among Vietnamese patients
Authors: Vu Nhu Thi Hanh , Le Huy Minh , Vo Diem Thi-Ngoc , Vu Hoang Anh , Le Nhan Quang , Ho Dung Dang Quy , Quach Duc Trong 
Published: February 2024

BACKGROUND
Sessile serrated lesions (SSLs) are considered precancerous colorectal lesions that should be detected and removed to prevent colorectal cancer. Previous studies in Vietnam mainly investigated the adenoma pathway, with limited data on the serrated pathway.
AIM
To evaluate the prevalence, risk factors, and BRAF mutations of SSLs in the Vietnamese population.
METHODS
This is a cross-sectional study conducted on patients with lower gastrointestinal symptoms who underwent colonoscopy at a tertiary hospital in Vietnam. SSLs were diagnosed on histopathology according to the 2019 World Health Organization classification. BRAF mutation analysis was performed using the Sanger DNA sequencing method. The multivariate logistic regression model was used to determine SSL-associated factors.
RESULTS
There were 2489 patients, with a mean age of 52.1 ± 13.1 and a female-to-male ratio of 1:1.1. The prevalence of SSLs was 4.2% [95% confidence interval (CI): 3.5-5.1]. In the multivariate analysis, factors significantly associated with SSLs were age ≥ 40 [odds ratio (OR): 3.303; 95%CI: 1.607-6.790], male sex (OR: 2.032; 95%CI: 1.204-3.429), diabetes mellitus (OR: 2.721; 95%CI: 1.551-4.772), and hypertension (OR: 1.650, 95%CI: 1.045-2.605). The rate of BRAF mutations in SSLs was 35.5%.
CONCLUSION
The prevalence of SSLs was 4.2%. BRAF mutations were present in one-third of SSLs. Significant risk factors for SSLs included age ≥ 40, male sex, diabetes mellitus, and hypertension.
Her Mother’s Tongue: Bilingual Dwelling, Being In-Between, and the Intergenerational Co-creation of Language-Worlds
Authors: Ngo Helen 
Published: February 2024

ABSTRACT
This article takes up the idea of language as a home and dwelling, and reconsiders what this might mean in the context of diasporic bilingualism, where as a “heritage speaker” of a minority language, the “mother tongue” may be experienced as both deeply familiar yet also alien or alienating. Drawing on a range of philosophical and literary accounts (Cassin, Arendt, Anzaldúa, Vuong, among others), this article explores how the so-called “mother tongue” is experienced by heritage speakers in an English-dominant world. From navigating one’s being in-between language-worlds, to the experience of language loss and efforts of reconnection, I argue that bilingual dwelling involves many complex layers often overlooked by philosophical accounts of language that do not attend to the lived world of the migrant and racialized outsider. By turning to the example of bilingual parenting, I then examine how such an undertaking, while labor-intensive, offers opportunities to refresh and co-create language-worlds anew.
Fatal Longings: Nostalgia, Slavery, and Medicine
Authors: Luzardo Jesús 
Published: February 2024

ABSTRACT
This article analyzes the politics of nostalgia’s history as a fatal disease between the seventeenth and nineteenth centuries, especially as it was applied to slaves in late eighteenth-century Cuba. I trace nostalgia’s medical history beginning with its inauguration in Swiss medicine in 1688, and then describe the contours of its transformation into a military disease primarily affecting white soldiers in France and the United States. Finally, I translate and analyze key elements of Francisco Barrera y Domingo’s work on nostalgia as experienced by slaves in sugar mills in Havana. I show that Barrera uses his analysis of nostalgia and its treatment to describe the slaves’ harrowing conditions and homesickness. Nevertheless, in denying slaves the ability to return home and in failing to propose the abolition of the slave system in the wake of the Haitian Revolution, I argue, Barrera in fact deploys the diagnosis of nostalgia in order to medicalize and pathologize the slaves’ reactions and resistance to their captivity. Thus, despite his sympathy to the slaves, I conclude that for Barrera, nostalgia functions as a tool to better manage the slaves as laborers and as property.
Perceptions of female-perpetrated intimate partner homicide – Construction and initial validation of a novel scale
Authors: Crosland Sally , Tzani Calli , Ioannou Maria 
Published: February 2024

Key digested messageWomen who commit intimate partner homicide (IPH) are often described in stereotypical ways, such as unfeminine and therefore beyond explanation. Previous research suggests that stereotypical viewpoints have an impact in trial situations. To investigate the extent to which stereotypical beliefs play a part in sentencing, a scale was developed, to measure attitudes towards female perpetrators of IPH. The current project tests the developed scale, which measures attitudes towards female perpetrators of intimate partner homicide in the United Kingdom. Following an extensive review of the literature, a total of 107 items were generated overall, reflecting the stereotypical categories. An expert pool analysed how well each item reflected the category to which it was assigned. This research identified four factors associated with stereotyping of female intimate partner homicide perpetrators, suggesting that specific concepts exist in relation to attitudes towards female homicide perpetrators. The scale could assist in jury verdicts.
A prospective observational study correlating possible novel biomarkers with disease severity and antihistamine response in chronic spontaneous urticaria
Authors: Bhatia Divya , Mehta Hitaishi , Bishnoi Anuradha , Srivastava Niharika , Vinay Keshavamurthy , Parsad Davinder , Kumaran Muthu Sendhil 
Published: February 2024

Background:
Role of complement fraction 5a (C5a), interleukin (IL)-9, and apolipoprotein (apo) A-IV as biomarkers of disease severity and antihistamine response in chronic spontaneous urticaria (CSU) remains elusive.

Objective:
To identify the role of C5a, IL-9, and apo A-IV as potential biomarkers in predicting disease severity and antihistamine response in CSU patients.

Methods:
This was a prospective observational study of 95 patients and 42 controls. Serum analysis of C5a, IL-9, and apo A-IV was done using enyzme linked immunosorbent assay kits. Also, serum IgE and anti-thyroid peroxidase (TPO) levels were assessed in all patients. All patients were started on oral levocetirizine 5 mg at baseline and dose was titrated upwards to maximum of 20 mg based on response. Patients were categorized into antihistamine responders or nonresponders as per their disease response. Serological markers, serum IgE, and anti-TPO were correlated with baseline disease severity and antihistamine response.

Results:
C5a levels were significantly higher in cases as compared to controls (P = 0.004). Significantly higher IL-9 levels were observed in antihistamine responders than nonresponders (P = 0.008). Baseline urticaria severity demonstrated a statistically significant positive and negative correlations with IL-9 (ρ = 0.277, P = 0.007) and apo A-IV (ρ = −0.271, P = 0.008) levels, respectively. Levels of serum IgE (P = 0.031) and anti-TPO (P = 0.039) were significantly higher in antihistamine nonresponders compared to responders.

Conclusions:
IL-9 and apo A-IV might be potential novel biomarkers to predict urticaria severity. Higher IL-9 might be a predictor of antihistamine response. Elevated anti-TPO and serum IgE might predict poor antihistamine response.
Anti-thymic stromal lymphopoietin monoclonal antibody in patients with chronic rhinosinusitis with nasal polyps (DUBHE): Rationale and design of a multicenter, randomized, double-blind, placebo-controlled study
Authors: Shen Shen , Xian Mu , Yan Bing , Lan Feng , Wang Chengshuo , Zhang Luo 
Published: February 2024

Background:
Chronic rhinosinusitis with nasal polyps (CRSwNP) has a complex pathogenesis and is difficult to treat, which brings a huge economic burden to society. Despite all the progress in the treatment of CRSwNP, some patients with CRSwNP still experience recurrence. Therefore, there is an urgent need to develop novel drugs and treatments for CRSwNP. Thymic stromal lymphopoietin (TSLP) is produced by epithelial cells and mediates type 2 and nontype 2 inflammation through various downstream cellular immune and inflammatory pathways. Anti-TSLP treatment with tezepelumab has been proven to be effective in treating patients with uncontrolled asthma, regardless of their peripheral blood eosinophil levels being low or high. However, there is no relevant research on the usage of anti-TSLP monoclonal antibodies for the treatment of uncontrolled CRSwNP.

Objective:
This is the first phase Ib/IIa study for subjects with uncontrolled CRSwNP, aiming to evaluate the safety, tolerability, pharmacokinetics, pharmacodynamics, immunogenicity, and preliminary efficacy of multiple ascending doses (MAD) of anti-TSLP monoclonal antibody.

Methods:
The DUBHE is a multicenter, randomized, double-blind, placebo-controlled, phase Ib/IIa clinical study. The study will be composed of 3 periods: a screening/run-in period of 4 weeks, a treatment period of 52 weeks (16 weeks of double-blind treatment period +36 weeks of open-label treatment period), and a safety follow-up period of 12 weeks. No more than 113 subjects with uncontrolled CRSwNP will be divided into 4 groups to receive different doses of CM326 or placebo treatments (55 mg every two weeks [Q2W] group, 110 mg Q2W group, 220 mg Q2W group, and 220 mg every four weeks [Q4W] group). Enrolled patients will be stratified by tissue eosinophil count (TEC).

Results:
The safety of the monoclonal antibody that targets TSLP in uncontrolled CRSwNP and its preliminary efficacy at 16 weeks of treatment.

Conclusion:
In this study, for the first time, the safety and preliminary efficacy of MAD of CM326 will be verified. The efficacy of CM326 in patients with eosinophilic CRSwNP (TEC ≥55/ high power field [HPF]), as well as noneosinophilic CRSwNP (TEC <55/HPF) will be testified.

Trial registration:
NCT05324137.
Kedisiplinan Santri Pondok Pesantren Madinatunnajah Kota Cirebon
Authors: Barnawi Barnawi 
Published: February 2024

This research aims to obtain results regarding discipline carried out by the Madinatunnajah santri organization. This research uses qualitative research with a case study approach. Data collection techniques use in-depth interviews, observation and documentation. Meanwhile, data analysis was carried out using Miles and Huberman analysis through the stages of data reduction, data presentation and drawing conclusions. The research results show that the leadership carried out by the Madinatunnajah santri organization has implications for discipline. The leadership management carried out by the Madinatunnajah santri organization is carried out by planning, analyzing the background, determining goals and objectives, while the organizing carried out by the Madinatunnajah OSMAN santri organization is by establishing a structure through leadership deliberation, while the implementation is carried out by carrying out programs according to each division. respectively, providing motivation as well as implementing discipline through rules, advice and example. Meanwhile, supervision is carried out through program supervision through supervision by OSMAN administrators of all students in various activities, by providing rewards and punishments, conducting evaluations and upgrading. Meanwhile, student discipline is seen from two indicators, namely time discipline during activities and action discipline by using time for productive activities.
Keywords : discipline, santri, Islamic boarding school
Acuerdos de colaboración para la prestación de servicios en el ámbito local en perspectiva comparada
Authors: Huete García Mª Angeles , Navarro Clemente J 
Published: February 2024

Este artículo analiza las estrategias de colaboraciónpara la prestación de servicios a nivel local en los municipiosde España, Estados Unidos y Noruega. Deforma concreta, se centra en la importancia y naturalezacon la que dicha estrategia se desarrolla en loscasos mencionados, así como el papel que diversosfactores tienen en ella. Para ello, se atiende a elementosde la dinámica social, económica y políticadel municipio, pero también a elementos del diseñoinstitucional que configuran la posición que las administracioneslocales ocupan en el sistema de gobiernolocal en cada caso. Ello requiere un planteamientoanalítico en dos niveles diferentes. Uno de ellos, elque denominamos meso, atiende a elementos del di-
seño institucional que operan en el municipio comoun elemento determinante en los modelos de coproducciónde servicios. El otro nivel, denominado micro,atiende a aquellos elementos que sitúan en la sociedadpolítica local, determinando también las oportunidadesde las administraciones locales para el desarrollode sus estrategias.
BIOLOGI KRIMINAL, PSIKOLOGI KRIMINAL DAN SOSIOLOGI KRIMINAL DALAM TINJAUAN HUKUM PIDANA
Authors: Begouvic M Eza Helyatha , Yudistira Erik , Nasril Senja 
Published: February 2024

Pengertian kriminologi adalah ilmu pengetahuan yang mempelajari sebab akibat, perbaikan dan pencegahan kejahatan sebagai gejala manusia dengan menghimpun sumbangan-sumbangan berbagai ilmu pengetahuan. Tugasnya kriminologi merupakan sarana untuk mengetahui sebab-sebab kejahatan dan akibatnya yang mempelajari cara-cara mencegah kemungkinan timbulnya kejahatan. bahwa disamping ilmu hukum pidana yang juga dinamakan ilmu tentang hukumnya kejahatan, ada juga ilmu tentang kejahatan itu sendiri yang dinamakan kriminologi, kecuali obyeknya berlainan dan tujuannya pun berbeda, dimana hukum pidana adalah peraturan hukum yang mengenai kejahatan atau yang berkaitan dengan pidana dengan tujuan ialah agar dapat dimengerti dan dipergunakan dengan sebaik-baiknya dan seadil-adilnya sedangkan obyek kriminologi adalah kejahatan itu sendiri, tujuannya mempelajari apa sebabnya sehingga orang yang melakukan dan upaya penanggulangan kejahatan itu. Pendekatan penelitian ini ialah pendekatan penelitian Yuridis-Normatif. Sumber data penelitian ini diambil dari beberapat literatur yang ada di Perpustakaan offline maupun digital.
A incidência de sífilis adquirida na população masculina nas capitais brasileiras 2021 a 2021
Authors: Salles da Silva Maria Fernanda , Schneider dos Santos Mariana Conceição , Aratani Nathan 
Published: February 2024

Introdução: A inclusão da população masculina passou a ser discutida pelas equipes de saúde visto a baixa procura em consultas de rotina dessa população, onde somente procuram os serviços de saúde com queixas agudas. As dificuldades descritas em relação a não adesão do homem aos serviços de saúde, incluem: não considerar a prevenção em saúde algo importante, não gostar de frequentar os serviços de saúde, questões relacionadas ao trabalho, indisponibilidade de tempo, desconhecimento sobre o direito de participar da consulta pré natal e desinteresse muitas vezes, medo, falta de acessibilidade, escassez de insumos, etc¹,². Concomitante a isso, a atenção primária por seu caráter abrangente, tem papel de elaborar estratégias para o controle de infecções, por meio desta é possível realizar o diagnóstico, tratamento e controlar a disseminação da sífilis. Objetivo: Analisar a evolução/tendência dos casos de sífilis adquirida na população masculina no ano de 2012 e 2021. Metodologia: Trata-se de uma análise descritiva, com coleta de dados secundários extraídos no portal Departamento de HIV/Aids, Tuberculose, Hepatites Virais e Infecção Sexualmente Transmissíveis em janeiro de 2023. os dados foram organizados no software Microsoft Excel e posteriormente analisados. Foi levantada a distribuição percentual do sexo masculino a cada 100.000 habitantes. Resultados: Entre a população masculina, destacam-se os estados: Distrito Federal (0,922), Minas Gerais (0,917), Rio de Janeiro (0,905), Pará (0,903) e Santa Catarina (0,891). Conclusão: São necessários estudos sobre os casos de Sífilis na população masculina no Brasil, visto a quantidade elevada de taxa de detecção. A população masculina está exposta a uma série de fatores que levam ao maior risco de infecções como múltiplas parceiras sexuais, ausência do uso de preservativo, fatores sociais e estilo de vida, entre outros. A sífilis é um grave problema de saúde pública que trás a tona uma falha no sistema em questão de promoção e educação em saúde, deste modo, a atenção primária busca e necessita de estratégias para abranger mais esta população, além do pré-natal do parceiro com a população masculina e reformulação de antigas estratégias para efetividade do controle³.
Efeito do uso de taping no pós-operatório de cirurgias plásticas em mulheres
Authors: Cornaccini Martines Lorena , Gomes Reichel Paola Thaís , Albuquerque Dias Donato Priscila Rosa , De Carvalho Schweich Adami Laynna , Gomes de Souza Pegorare Ana Beatriz 
Published: February 2024

Introdução e objetivo: A dor é uma das queixas mais usuais no período pós operatório de cirurgia plástica, apesar das medicações existentes, somado à cinesiofobia e o desconforto musculoesquelético seguido do edema e equimoses, afetam muito a qualidade de vida da mulher no período pós operatório. A fisioterapia possui algumas técnicas para minimizar esses efeitos, dentre elas o uso do taping na prática clínica, porém sem evidência científica na literatura. O objetivo desta pesquisa foi revisar sistematicamente estudos publicados a respeito da aplicação da técnica de taping no pós-operatório de cirurgias plásticas. Material e métodos: Esta pesquisa trata-se de uma revisão sistemática da literatura. Com protocolo registrado no PROSPERO (Registro prospectivo internacional de revisões sistemáticas) sob o número: CRD42022339803. Foi realizada uma revisão sistemática da literatura, no período do mês de março de 2023, nas bases de dados eletrônicas Medline via Pubmed, Embase, CINAHL, LILACS, PEDro, e SPORTDiscus, utilizando as palavras-chave “cirurgia plástica” e “taping” e as estratégias de busca foram adaptadas para cada banco de dados e com a utilização do software EndnoteX8 por dois avaliadores independentes.Resultados e discussão: Após levantamento de 509 artigos, apenas 6 foram consideráveis elegíveis para a pesquisa, em relação às intervenções com taping em pós de cirurgia plástica, no desfecho de dor muscular, fibrose e edema. Conclusão: O uso do taping tem demonstrado efeito benéfico sobre o alívio da dor e desconforto no período pós operatório de cirurgia plástica, sendo assim, esta revisão não recomenda o uso do taping em substituição à Fisioterapia dermatofuncional convencional, mas como um recurso complementar a esta, na prática clínica.
A Closer look into recent economy, Whether or not Vietnam faces a 10-year crisis?
Authors: Tuan Dinh Cong  , Sun Ying Jun  
Published: February 2024

From 2018, the global economy began to grow strongly and synchronously, but as 2018 passed, the development momentum has become slower, faded, along with biased growing trends. The US economy has accelerated thanks to fiscal stimulus policies early this year, while the economy of the EU, Britain, Japan and China began to weaken. These differences will continue to exist in 2019 and Vietnam is not excluded. This study is a closer look into Vietnamese economy from 2007 up to now & prediction to the upcoming period. Objective: The present study aims at giving predictions & recommendations to sustain Vietnam’s economy in the next years based on analyzing multiple economic indicators such as: economic growth rate, inflation, unemployment rate, import and export throughout the period 2007 – 2018. Material and methods: General information about the Vietnam’s economy & crisis trend was collected from the documentation provided by National Financial Committee as well as economic websites. Then, the authors analyzed & made comparisons between years to years & created tables to show them clearly. Secondary data, such as theoretical frameworks and literature, were obtained from reference books, scientific books, scientific articles and peer reviewed journals. Results: The economy since 2007 has been so volatile: the economic growth rate fell erratically, unpredictably; unemployment & inflation rate are still really big problems while import, export & investment have prospered gradually. Conclusions: Vietnam's economy is on a good & rapid growth path, with many economic advantages. However, in essence, Vietnam is still a young economy, so we need to be well prepared to cope with major economic fluctuations that may occur, possibly next year – the beginning year of the 10-year crisis period.
Khảo sát tác dụng kháng viêm của cao chiết nước lá cây Lấu đỏ (Psychotria rubra (Lour.) Poir., Rubiaceae)
Authors: Hoàng Thị Phương Liên  , Nguyễn Ngọc Bảo Châu  
Published: February 2024

Ở Việt Nam, Lấu đỏ (Psychotria rubra) được dùng như một dược liệu dân gian. Nghiên cứu này được thực hiện nhằm đánh giá tác dụng kháng viêm của cao chiết nước từ lá cây Lấu đỏ trên mô hình thực nghiệm: gây phù chân chuột bằng carrageenan 1%, đo thể tích bàn chân chuột sau gây viêm tại các thời điểm: 0 giờ, 3 giờ, 6 giờ, 24 giờ, 48 giờ, 72 giờ, 96 giờ, 120 giờ, 144 giờ. Thuốc đối chứng là diclofenac 5mg/kg. Kết quả thống kê cho thấy Cao chiết nước từ lá cây Lấu đỏ làm giảm độ phù chân chuột ở cả hai liều 2,50g/kg và 1,25g/kg.
Khảo sát sơ bộ qui trình phân lập thành phần hóa học của lá cây Dó Bầu (Aquilaria crassna Pierre)
Authors: Ngô Thị Châu  
Published: February 2024

Bài báo trình bày về qui trình phân lập thành phần hóa học của lá cây Dó Bầu được hái ở tỉnh Bình Phước. Qui trình thể hiện rõ từng giai đoạn của quá trình nghiên cứu từ xử lí lá tươi đến khi thành cao. Từ 7kg lá tươi sau khi phơi khô và sấy thu được 2,5kg lá khô, trích 3 lần với metanol bằng phương pháp đun hoàn lưu, mỗi lần trích là 2giờ. Toàn bộ dịch trích được đem cô quay áp suất thấp thu được cao metanol. Cao khô metanol được trích với acetat etyl thu được cao acetat etyl. Từ cao acetat etyl thực hiện sắc kí cột silicagel với nhiều hệ giải li thu được 5 phân đoạn từ C1- C5, sau đó sắc kí cột phân đoạn C2 với nhiều hệ dung li khác nhau qua nhiều phân đoạn kế tiếp thu được chất tinh khiết CC2 (5mg). Kết quả của thực nghiệm thu được một qui trình phân lập thành phần hóa học của lá cây Dó Bầu qua từng giai đoạn. Dựa vào số liệu phổ 1H, 13C NMR, phổ 2D-NMR HSQC, HMBC kết hợp với tài liệu, cấu trúc hợp chất được đề nghị là 7-O-metilapigenin 5-O-[β –D-xylopyranosyl-(1→6)- β-D-glucopyranoside].
Khảo sát tình trạng sức khỏe của sinh viên Đại học Nguyễn Tất Thành năm 2017
Authors: Lê Thị Thu Hương  , Nguyễn Hoàng Thanh Thanh  , Nguyễn Duy Tài  
Published: February 2024

Tình hình và mục tiêu nghiên cứu: Sinh viên luôn là một đối tượng được xã hội chú trọng vì sinh viên đóng vai trò quan trọng trong sự phát triển của đất nước. Đào tạo ra những con người có sức khỏe và trình độ cao là nhiệm vụ của ngành giáo dục. Bên cạnh đó, trong những năm gần đây Trường Đại học Nguyễn Tất Thành có rất ít đề tài nghiên cứu về lĩnh vực sức khỏe sinh viên. Mục tiêu của nghiên cứu này là “Khảo sát tình trạng sức khoẻ của sinh viên năm 2017 Trường Đại học Nguyễn Tất Thành”.
Phương pháp nghiên cứu: Mô tả cắt ngang. Đối tượng nghiên cứu: Sinh viên đại học chính qui nhập học năm 2017 – 2018. Bao gồm 951 sinh viên trong đó có 311 sinh viên nam, 640 sinh viên nữ tham gia kì khám sức khỏe dành cho tân sinh viên nhập học.
Kết quả: Tình trạng thể lực của sinh viên: thể lực loại I 79,7%, loại II 13,33%, loại IV 2,84%, loại V 0,55%. Mô hình bệnh tật của sinh viên: Bệnh lí mắt: tỉ lệ sinh viên mắc tật khúc xạ là 49,8%. Bệnh lí RHM chiếm 23.3%, bệnh lí TMH chiếm 1,7. Bệnh lí nội khoa chiếm 2,3% với chủ yếu là bệnh tim mạch, hô hấp.