bluuebunny/crossref_metadata_2025_split huggingface dataset:
Concepts of MRI quantification of iron in the liver: present and future of modern multiparametric methods: a review
Authors: Galyan T. N. , Bril K. R. , Prohorova E. A. , Logunova T. A. , Khovrin V. V. 
Published: February 2025

INTRODUCTION: Accumulation of excess iron in the body or systemic iron overload occurs for various reasons, mainly as a result of inherited disorders of iron regulatory pathways, long-term and/or regular blood transfusions, uncontrolled breakdown of hemoglobin in hemolytic anemias, hematological malignancies. Mild iron overload can be associated with chronic liver disease and metabolic syndrome (dysmetabolic iron overload).Despite optimal control of chelation, iron is deposition in vital organs such as the liver, heart, endocrine glands and subsequently damaged. Liver Iron Concentration (LIC) is linearly related to total body iron stores and may contain about 70% of the iron in the body. The introduction of MRI into the examination algorithm for patients with storage diseases provides the opportunity for early diagnosis of iron overload and monitoring the effectiveness of therapy.OBJECTIVE: To summarize the current state and prospects for the clinical use of MR methods for quantitative assessment of iron content in the liver.MATERIALS AND METHODS: An analysis of the main publications of domestic and foreign literature on non-invasive assessment of the degree of liver iron overload over the past 10 years was carried out in the main medical databases: Medline/PubMed, RISC/Elibrary, CyberLeninka, Google Scholar.RESULTS: It was revealed that the main methods of MRI noninvasive assessment of the iron content in the liver are SIR and R2* – relaxometry. The latter defines modern approaches to both qualitative and quantitative assessment of iron overload, providing a linear correlation with LIC. Information about diffuse changes in the parenchyma is important, since the presence of fat deposits in the liver can lead to an increase in R2*, therefore, a simultaneous quantitative determination of iron and fat deposits in the liver is completely rational.CONCLUSION: Diagnosis of liver iron overload is necessary to control and adjust the optimal treatment to prevent side effects of chelation therapy. To this end, the use of MRI has an enormous role, since the simultaneous acquisition of quantitative data on R2* and PDFF allows a comprehensive assessment of fat content and the degree of iron overload, which is not available to other imaging methods. The introduction of multiparametric liver MRI protocols with adaptation to new software will allow us to reach a new level of diagnosis of liver diseases.MRI is the main tool for visualization, quantification and identification of the risks of liver iron overload. Modern multiparametric MRI of the liver has promising clinical significance for the quantitative assessment of iron deficiency and the degree of steatosis in the complex diagnosis of diffuse liver diseases.
The possibilities of prostate cancer radioligand therapy with low-molecular-weight PSMA inhibitors labeled with actinium-225: a review
Authors: Tishchenko V. K. , Krylov V. V. , Kochetova T. Yu. , Shurinov A. Yu. , Vlasova O. P. , Shegai P. V. , Ivanov S. A. , Kaprin A. D. 
Published: February 2025

INTRODUCTION: The terminal form of prostate cancer known as metastatic castrate-resistant prostate cancer (mCRPC) is a progressive disease with limited therapeutic options and poor survival prognosis. Therefore, there is a high demand for more effective (targeted) strategies of systemic therapy. Radioligand therapy (RLT) offers the possibility to treat mCRPC in a specific and tumor-selective manner by targeting prostate-specific membrane antigen (PSMA), which is overexpressed by prostate tumor cells.OBJECTIVE: To analyze the efficacy and safety of RLT of mCRPC using low molecular weight PSMA inhibitors labeled with alpha-emitting radionuclide 225Ac based on the literature data.MATERIALS AND METHODS: Literature search was performed during a period of 01.04.2024 to 27.04.2024 in Russian and English language in databases Medline/PubMed, Google Scholar, RINC/Elibrary using the following keywords: actinium-225 (225Ac), PSMA, 225Ac-PSMA, radioligand therapy of prostate cancer.RESULTS: This review presents the current worldwide experience of mCRPC RLT using low-molecular-weight PSMA inhibitors labeled with the alpha-emitting radionuclide 225Ac. Data on the efficacy of RLT with 225Aс-PSMA-617 and 225Aс-PSMA-I&T as well as the results of tandem therapy are presented. The toxicity of this treatment is discussed in detail, and ways of their avoidance or reduction their intensity are reviewed.DISCUSSION: RLT with 225Ac-PSMA ligands is an effective and safe strategy for mCRPC therapy, including tumors, which are resistant to conventional therapies, and also in case of inefficacy of RLT with 177Lu-PSMA. More than a half of treated patients had PSA levels declined greater than 50%. The most common complication of RLT is xerostomia.CONCLUSION: RLT with 225Ac-labeled PSMA-specific ligands is a promising therapy for patients with mCRPC, who have exhausted all possible antitumor therapies.
Investigation of pulmonary artery dilation in the population of Moscow using automated analysis of radiological examination results
Authors: Solovev A. V. , Vasilev Yu. A. , Sinitsyn V. E. , Vladzymyrskyy A. V. , Ivanova G. V. 
Published: February 2025

INTRODUCTION: In modern clinical practice, the diagnosis establishment and monitoring of pulmonary arteries are important components of care for patients with cardiovascular and respiratory diseases. However, in Russia, there remains a limited amount of epidemiological data on the prevalence of pulmonary artery dilation, especially at the population level.This study aims to fill this gap by providing population-based data on the prevalence of pulmonary artery dilation in the city of Moscow. With the help of advanced artificial intelligence technologies, this work seeks to offer a comprehensive assessment of the pathology, covering both its main characteristics and the effects of various factors such as age and gender.OBJECTIVE: To investigate the prevalence of pulmonary artery dilation in Moscow using the data from computed tomography (CT) scans of the chest analysed by means of an automatic artificial intelligence technology.MATERIALS AND METHODS: The study involved the analysis of a large volume of chest CT scans acquired from September 2022 to February 2023. The total study sample comprised 134,218 patients. Artificial intelligence technologies were applied for the automatic detection of signs of pulmonary artery dilation.RESULTS: An analysis of 125,878 CT scans, including 57,913 men and 67,965 women, revealed that 34.4% of patients (43,242 individuals) showed signs of pulmonary artery dilation. Among them, the proportion of men with this pathology was 35.6% (20,630 individuals), while for women it was 33.3% (22,612 individuals). The prevalence of the pathology increased with age, starting at 14.8% among younger patients and reaching 62.7% among the elderly. The prevalence of pulmonary artery dilation among the population of Moscow was 794.7 cases per 100,000 people.DISCUSSION: The results of this research allowed us to draw conclusions regarding the meaning of pulmonary artery dilation as a predictor of pulmonary hypertension. The results demonstrated a correlation between the frequency of pathology occurrence and gender and age groups, with a more pronounced association observed in women. Detailed analysis also revealed corellations of pulmonary artery diameter with age and gender.CONCLUSION: The study provided the first population-based data on the prevalence of pulmonary artery dilation in Moscow. The importance of early diagnosis to prevent severe complications, especially in patients with chronic lung diseases, is emphasized. The study results can provide a basis for screening strategies and treatment approaches for this pathology.
DETERMINANTS OF GENERATION Z INTEREST IN APPLYING FOR PEER-TO-PEER LENDING CREDIT FACILITIES AT DIGITAL BANKS
Authors: Karyadi M. Nurdian 
Published: February 2025

This study aims to identify and analyze the factors influencing Generation Z's interest in applying for peer-to-peer (P2P) lending facilities at digital banks. In the rapidly advancing digital era, P2P lending has become an attractive alternative financing option for the younger generation, particularly Generation Z, who are known for their high adaptability to technology. The research employs a quantitative method with data collection conducted through a questionnaire distributed to 200 respondents from Generation Z. Data analysis is performed using multiple linear regression techniques to test the influence of independent variables on interest (dependent variable). The independent variables tested include financial literacy, perceived ease of use, perceived usefulness, and trust. The results indicate that financial literacy, perceived ease of use, perceived usefulness, and trust significantly influence Generation Z's interest in using P2P lending facilities. Perceived usefulness and trust were found to be the most dominant factors affecting Generation Z's decisions. It is recommended that digital banks and P2P lending providers enhance financial education and literacy, develop user-friendly applications, and ensure service transparency and security. Implementing effective marketing strategies through social media and collaborating with educational institutions are also crucial to attract Generation Z's interest.

Keywords: Generation Z, Peer-to-Peer Lending, Digital Banks, Interest, Financial Literacy, Perceived Usefulness, Trust.
INFLUENCE OF MARKET ORIENTATION AND ENTREPRENEURSHIP ORIENTATION ON MODERATED COFFEE SHOP PERFORMANCE (M) SOCIAL MEDIA IN COFFEE SHOP IN JAMBI CITY
Authors: Zuhri Almuluk Fajar , Fitriaty Fitriaty , Indrawijaya Sigit 
Published: February 2025

This research aims to analyze the influence of Market Orientation and Entrepreneurship Orientation on Coffee Shop Performance, with Social Media as a moderating variable. This research was conducted at 49 Coffee Shops in Jambi City, using a questionnaire method to collect data. The analysis tool used is SmartPLS.
The research results show that Market Orientation has no significant effect on Coffee Shop Performance, with a T-statistics value of 0.059 and a P-value of 0.477. On the other hand, Entrepreneurial Orientation has a positive and significant influence on Coffee Shop Performance, with a T-statistics value of 1.797 and a P-value of 0.036. Social Media has also been proven to have a positive and significant influence on Coffee Shop Performance, with a T-statistics value of 2,276 and a P-value of 0.011.
In addition, this research found that Social Media does not moderate the influence of Market Orientation on Coffee Shop Performance, with a T-statistics value of 0.039 and a P-value of 0.484. However, Social Media moderates the influence of Entrepreneurial Orientation on Coffee Shop Performance, with a T-statistics value of 2.019 and a P-value of 0.022.
These findings indicate that Entrepreneurial Orientation and the use of Social Media play an important role in improving Coffee Shop Performance. Therefore, Coffee Shop owners are expected to increase their entrepreneurial orientation and utilize social media more effectively to achieve better performance.

Keywords: Market Orientation, Entrepreneurship Orientation, Social Media and Coffee Shop Performance.
INFLUENCE OF GREEN MARKETING ON GREEN PURCHASE INTENTION MEDIATED BY ENVIRONMENTAL AWARENESS
Authors: Risyafani Sonia , Musnaini Musnaini , Adriani Zulfina 
Published: February 2025

This study aims to explain how Green Marketing influences Green Purchase Intention mediated by Environmental Awareness among Starbucks consumers in Jambi City. The sampling method used is Purposive Sampling with a total of 100 respondents. Primary data were obtained through a questionnaire using a Likert scale. The data analysis method employed Partial Least Square (PLS) with Smart PLS 4.0 software. The results showed that Green Marketing has a positive and significant effect on Environmental Awareness, and Environmental Awareness has a positive and significant effect on Green Purchase Intention. Green Marketing also has a positive and significant impact on Green Purchase Intention mediated by Environmental Awareness. Based on these findings, it is suggested that marketers implement Green Marketing strategies strengthened by enhancing consumer Environmental Awareness, as consumer attitudes and concerns about the environment can increase the intention to purchase environmentally friendly products.

Keyword: Green Marketing, Environmental Awarenss, Green Purchase Intention
Multilevel lesions of lower extremities arteries: choosing the optimal surgical approach
Authors: Oborin A. A. , Muchamadeev I. S. , Lazarev S. M. , Nekrasov D. A. , Danilov V. N. 
Published: February 2025

INTRODUCTION. One of the important problems in cardiovascular surgery is the multilevel lesions of the lower extremity arteries. We presented the results of treatment of multilevel arterial lesion.METHODS AND MATERIALS. We analyzed the treatment results of 90 patients with combined lesions of the aortofemoral and femoral-popliteal segment of type TASC C and D. The patients were divided into 2 groups and 2 subgroups. Group 1 consisted of patients who underwent combined multilevel interventions, in turn, group 1 was divided into 2 subgroups according to the type of interventions. Group 1A – closed remote endarterectomy (RE) from the iliac arteries + femoral-popliteal (tibial) bypass surgery. Group 1B – aorto (iliac) – femoral bypass + RE from the arteries of the femoral-popliteal segment. Group 2 consisted of patients who underwent combined aorto (iliac) femoral + femoral-popliteal (tibial) bypass surgery.RESULTS. There were no registered cases of shunt thrombosis in the early postoperative period in group 1, whereas in group 2, both aorto-femoral and femoral-popliteal shunt thrombosis occurred in three cases (12%) in the early postoperative period. In group 1, 1 episode of bleeding was registered that required revision, in group 2, no bleeding was registered. In groups 1 and 2, 1 case of myocardial infarction (MI) was registered in the early postoperative period (p=0.301), one patient in group 2 had a stroke with regression of symptoms in the postoperative period. There were no deaths or amputations in the early postoperative period in group 1. In group 2, two patients (8%) underwent amputation in the early postoperative period, one patient died in the postoperative period. The primary patency in group 1A by 12, 24 and 60 months was 95 %, 76 % and 63 % respectively, in group 1B by 12, 24 and 60 months was 86 %, 86 % and 81 %, respectively, in group 2 by 12, 24 and 60 months was 100 %, 100 % and 85 %, respectively (p=0.368). Secondary patency in group 1A by 12 months was 77 %, by 24 months was 77 % and by 60 months was 52 %. In group 1B – by 12 months – 100 %, by 24 months – 67 %. In group 2 – by 12 months and 24 months – 50 % (p =0.983).CONCLUSIONS. Thus, if it is impossible to perform hybrid procedures, combined interventions for multi-level lesions of lower extremity arteries is an acceptable alternative to multi-level bypass. There was no difference in long-term patency between the compared methods of interventions, but the presence of fatal complications in the group of multilevel bypass indicates the advantage of a less invasive approach.
Modern approaches to diagnosis and surgical treatment of patients with acute obstructive intestinal obstruction
Authors: Samartsev V. A. , Pushkarev B. S. , Gavrilov V. A. , Parshakov A. A. , Kuznetsova M. P. , Domrachev A. A. 
Published: February 2025

The OBJECTIVE of the study was to improve the results of surgical treatment of patients with acute obturation intestinal obstruction of tumor and non-tumor origin by improving the algorithm for perioperative diagnosis and treatment of complications.METHODS AND MATERIALS. A single-center retrospective-prospective study of the results of treatment of patients with acute obturation intestinal obstruction (n=249) was conducted. The comparison group (n=125) was represented by a retrospective sample of patients whose examination and surgical treatment were carried out in accordance with the established procedure for providing medical care. Observation group (n=124): patients whose examination and surgical treatment were supplemented by assessment of the degree of compensation for acute obturation intestinal obstruction, the use of specialized scales, computer monitoring of intra-abdominal pressure and intraoperative assessment of microcirculation in the wall of the colon in patients with acute obturation intestinal obstruction (AOIO) using original methods.RESULTS. In the observation group, the time from admission to the hospital to surgical treatment was less than in the comparison group and amounted to 6.00 (Q1–Q3: 4.00–8.00) hours and 10.00 (Q1– Q3: 6.00–12.00) hours, respectively, (p <0.0001), mainly due to patients with a subcompensated form. Mortality in patients with acute obturation intestinal obstruction of tumor origin in the observation group was 11 (12.94 %) patients, in the comparison group – 16 (18.18 %) patients; non-tumor origin in the observation group – 8 (20.51 %), comparison – 10 (27.03 %) patients. Based on the conducted studies, an algorithm for perioperative diagnosis and treatment of complications was proposed.CONCLUSION. The differentiated choice of surgical tactics for acute obturation intestinal obstruction makes it possible to optimize the timing of surgical intervention, reduce the number of postoperative complications, as well as mortality in patients with acute obturation intestinal obstruction of tumor and non-tumor origin.
Impact of obesity on the severity, outcome and complications of acute pancreatitis
Authors: Kapralov S. V. , Potapov D. Yu. , Namatulin R. S. , Prohnitsky A. V. 
Published: February 2025

The OBJECTIVE was to study the effect of obesity on the severity of acute pancreatitis (AP), its outcome and complications.METHODS AND MATERIALS. The study included 212 patients with AP. Among the patients, 58 % (n=123) were men, and 42 % (n=89) were women. The severity of AP was mild in 63.2 %, moderate in 21.7 % and severe (SAP) in 15.1 % of cases. The average age of the patients was 52 years. Organ failure (both transient and persistent) was present in 20.3 % of all cases of AP, in 52.3 % of patients with moderate AP and in 59.4 % with SAP. The total mortality rate was 6.6 %, with mild and moderate AP, no deaths were noted, whereas with severe AP, the mortality rate was 43.8 %. The method of calculating body mass index (BMI) was used to diagnose obesity. The presence of obesity was noted at BMI of≥30 kg/m2. The number of obese patients was 39.6 % of all patients with AP. The Mann – Whitney U-test was used to compare patient groups. The criterion χ2 was used to compare the proportions of patients in different groups.RESULTS. When studying the average BMI and the proportion of obese patients, there were no significant differences in their values depending on the severity of AP. There were also no significant differences in the value of the average BMI and the proportion of obese patients in survivors and deceased patients with AP, as well as in survivors and deceased patients with SAP. Whereas, the surviving patients showed significant differences in the value of the average BMI and in the proportion of obese patients. There were no significant differences in the values of the average BMI and the proportion of obese patients in the groups of patients with OP without and with complications.CONCLUSION. Obesity does not significantly influence on the severity and frequency of complications in patients with AP.
Echocardiographic navigation in transapical neochord mitral valve repair with significant mitral regurgitation
Authors: Titov N. S. , Komok V. V. , Nemkov A. S. , Khubulava G. G. 
Published: February 2025

INTRODUCTION. Significant mitral regurgitation is currently a widespread acquired valvular heart disease and is associated with a significant decrease in survival and deterioration in quality of life. One of the new, unclearly studied, minimally invasive method for correcting significant mitral regurgitation is transapical neochord mitral valve repair, where echocardiography is the key imaging tool.The OBJECTIVE was to analyze the data of world studies devoted to the problem of echocardiographic navigation in transapical neochord mitral valve repair, to determine the echocardiographic criteria applicable to neochord implantation surgery. METHODS AND MATHERIALS. The analysis of studies about using echocardiography in the transapical neochord mitral valve repair has been carried out. Databases searched in this review included PubMed, ResearchGate, and Hindawi.RESULTS. During the analysis, we figured out that 2D and 3D transesophageal echocardiography is the main method for mitral valve imaging during transapical neochord mitral valve repair. Specific parameters which can be useful in addition for standard echocardiographic protocol of mitral valve evaluation have been identified.CONCLUSION. The results of the analysis showed that it is necessary to summarize the experience of present studies and standardize the approach to echocardiographic evaluation of the mitral valve during transapical neochord mitral valve repair.
ИЧНОСТНО ОРИЕНТИРОВАННЫЙ ПОДХОД В ОБУЧЕНИИ ДИРИЖИРОВАНИЮ В УЧЕБНО-ПРОФЕССИОНАЛЬНОЙ ДЕЯТЕЛЬНОСТИ МУЗЫКАНТА-ИНСТРУМЕНТАЛИСТА
Authors: Кобина Л.И. 
Published: February 2025

В статье рассматриваются некоторые педагогические аспекты процесса обучения оркестровому дирижированию музыканта-инструменталиста в условиях профессионального образования. Психолого-педагогическая сфера изучения проблем образования и воспитания музыканта неисчерпаема по своей культурно-социальной значимости, как и интеллектуальный потенциал человека, притягивающий научный интерес к роли личности в развитии музыкальной культуры. Главное внимание автора концентрируется на проблеме формирования личности студента в учебно-познавательной деятельности. Особо выделяется значение роли преподавателя в профессиональном взаимодействии со студентом в процессе изучения дисциплины. Автором предлагается углублённое видение педагогических задач и пути их решения в свете закономерных основ музыкально-слухового восприятия и методов личностно ориентированного подхода в профессиональном становлении музыканта.
Some educational issues of a process of teaching an instrumentalist musician to conduct orchestra as part of professional education are discussed in the article. The psychological and educational sphere of issues of musician education and development is inexhaustible in its cultural and social importance, just as human intellectual potential attracting research interest to a role of a personality in musical culture development is. The main author’s attention is focused on the issue of development of a student’s personality in his/her learning and cognitive activities. The importance of a teacher’s role in his/her professional interaction with a student in the process of the subject study is specially emphasized. The author proposes an advanced view on educational tasks and ways of their solution based on logical grounds of musical and aural perception and methods of personally oriented approach to a professional becoming of a musician.g and techniques of personality-oriented approach in the professional development of the musician.