bluuebunny/crossref_metadata_2025_split huggingface dataset:
Heterogeneity of endothelial VE-PTP downstream polarization, Tie2 activation, junctional claudin-5, and permeability in the aorta and vena cava
Authors: Baluk Peter , Shirakura Keisuke , Vestweber Dietmar , McDonald Donald M. 
Published: November 2023

AbstractEndothelial cells of mammalian blood vessels have multiple levels of heterogeneity along the vascular tree and among different organs. Further heterogeneity results from blood flow turbulence and variations in shear stress. In the aorta, vascular endothelial protein tyrosine phosphatase (VE-PTP), which dephosphorylates tyrosine kinase receptor Tie2 in the plasma membrane, undergoes downstream polarization and endocytosis in endothelial cells exposed to laminar flow and high shear stress. VE-PTP sequestration promotes Tie2 phosphorylation at tyrosine992 and endothelial barrier tightening. The present study characterized the heterogeneity of VE-PTP polarization, Tie2-pY992 and total Tie2, and claudin-5 in anatomically defined regions of endothelial cells in the mouse descending thoracic aorta, where laminar flow is variable and IgG extravasation is patchy. We discovered that VE-PTP and Tie2-pY992 had mosaic patterns, unlike the uniform distribution of total Tie2. Claudin-5 at tight junctions also had a mosaic pattern, whereas VE-cadherin at adherens junctions bordered all endothelial cells. Importantly, the amounts of Tie2-pY992 and claudin-5 in aortic endothelial cells correlated with downstream polarization of VE-PTP. VE-PTP and Tie2-pY992 also had mosaic patterns in the vena cava, but claudin-5 was nearly absent and extravasated IgG was ubiquitous. Correlation of Tie2-pY992 and claudin-5 with VE-PTP polarization supports their collective interaction in the regulation of endothelial barrier function in the aorta, yet differences between the aorta and vena cava indicate additional flow-related determinants of permeability. Together, the results highlight new levels of endothelial cell functional mosaicism in the aorta and vena cava, where blood flow dynamics are well known to be heterogeneous.
Why don’t we trace? A study on the barriers to software traceability in practice
Authors: Ruiz Marcela , Hu Jin Yang , Dalpiaz Fabiano 
Published: November 2023

AbstractResearchers have proposed numerous tools, methods, and techniques for establishing and maintaining software traceability. Despite its acknowledged importance, researchers argue that traceability is still “a sought-after, yet often elusive quality in software-intensive systems”. We have little evidence regarding how creating, managing, and using traceability links vary depending on factors such as organizational contexts, software development practices, and project types. We conduct an empirical study where software development practitioners express their perception regarding the value of software traceability. Via an online survey, 55 participants provided information related to their current traceability practices and needs. Furthermore, we interviewed 14 practitioners to gain a more in-depth understanding. Our study investigates the effect of two independent variables: the software development paradigm and the type of developed software system. Among the several identified findings, our analysis reveals that, although the traceability costs are an inhibitor for adopting more mature traceability practices, the respondents believe that the expected benefits still outweigh envisioned costs. Traceability is mainly performed manually: not only are automated trace retrieval tools scarce, but their offered automation is not expected to replace human involvement.
Short-term outcomes after open versus robot-assisted repair of ventral hernias: a nationwide database study
Authors: Henriksen N. A. , Helgstrand F. , Jensen K. K. 
Published: November 2023

Abstract
Purpose
The robotic platform is widely implemented; however, evidence evaluating outcomes of robotic ventral hernia repair is still lacking. The aim of the study was to evaluate the short-term outcomes after open and robot-assisted repair of primary ventral and incisional hernias.

Methods
Nationwide register-based cohort study with data from the Danish Ventral Hernia Database and the National Danish Patients Registry was from January 1, 2017 to August 22, 2022. Robot-assisted ventral hernia repairs were propensity score matched 1:3 with open repairs according to the confounding variables defect size, Charlson comorbidity index score, and age. Logistic regression analyses were performed for factors associated with length of stay > 2 days, readmission, and reoperation within 90 days.

Results
A total of 528 and 1521 patients underwent robot-assisted and open repair, respectively. The mean length of hospital stay in days was 0.5 versus 2.1 for robot-assisted and open approach, respectively (P < 0.001) and open approach was correlated with risk of length of stay > 2 days (OR 23.25, CI 13.80–39.17, P < 0.001). The incidence of readmission within 90 days of discharge was significantly lower after robot-assisted repair compared to open approach (6.2% vs. 12.1%, P < 0.001). Open approach was independently associated with increased risk of readmission (OR 21.43, CI 13.28–39.17, P = 0.005, P < 0.001).

Conclusion
Robot-assisted ventral hernia repair is safe and feasible and associated with shorter length of stay and decreased risk of readmission compared with open ventral hernia repair.
Occupational dualism and intergenerational educational mobility in the rural economy: evidence from China and India
Authors: Emran M. Shahe , Ferreira Francisco H. G. , Jiang Yajing , Sun Yan 
Published: November 2023

AbstractWe extend the Becker-Tomes model to a rural economy with farm-nonfarm occupational dualism to study intergenerational educational mobility in rural China and India. Using data free of coresidency bias, we find that fathers’ nonfarm occupation and education were complementary in determining sons schooling in India, but separable in China. Sons faced lower mobility in India irrespective of fathers’ occupation. Sensitivity analysis using the Altonji et al. (J. Polit. Econ. 113(1), 151–84, 2005) approach suggests that genetic correlations alone could explain the intergenerational persistence in China, but not in India. Farm-nonfarm differences in returns to education, and geographic mobility are plausible mechanisms behind the contrasting cross-country evidence.
High variability and exceptionally low thermal conductivities in nearshore sediments: a case study from the Eckernförde Bay
Authors: Usbeck Regina , Dillon M. , Kaul N. , Lohrberg A. , Nehring F. , Ploetz A. C. 
Published: November 2023

AbstractHeat flow measurements are a standard technique in Geophysics both onshore and offshore. Recently, such measurements became increasingly important in shallow waters. The increasing amount of offshore power installations makes it necessary to have a good knowledge about the subsurface heat flow and the thermal properties of the sediments to optimize the construction of the necessary powerlines. While the thermal properties are well studied for deep ocean sediments, only few published data exist for nearshore sediments. In this study, we investigate the sediment temperatures and thermal conductivities of nearshore sediments in the German part of the Baltic Sea. The shallow sediment temperatures reflect the interplay of the response to the seasonal cycle in connection with the sediments’ thermal conductivity. We find thermal conductivity values ranging from 0.67 to 3.34 W/(m*K) for the sediments down to ~ 4.2 m below seafloor. This variability exceeds that of conservative estimates widely used for coastal sediments and is also much higher than the variability found in the deep oceans. Sandy sediments show thermal conductivities larger than 1 W/(m*K) whereas organic-rich muds have lower values (< 1 W/(m*K)). Furthermore, the thermal conductivities seem to decrease with increasing free gas content in the sediment. The latter needs to be confirmed by further investigations.
An assessment of long-term and large-scale wetlands change dynamics in the Limpopo transboundary river basin using cloud-based Earth observation data
Authors: Gxokwe Siyamthanda , Dube Timothy , Mazvimavi Dominic 
Published: November 2023

AbstractSignificant progress has been made in monitoring and assessing the effects of land use and land cover (LULC) changes on wetland extent. However, our understanding of wetland within the transboundary basins has been limited by the scarcity of available data on their dynamic changes over time. This study aimed to address this gap by analyzing the long-term and large-scale spatio-temporal extent of wetland in the Limpopo transboundary river basin (LTRB) over a 20-year period (2000–2020). To achieve this, we utilized the Google Earth Engine (GEE) cloud-computing platform and various remotely sensed data. The study had two primary objectives; (1) to examine LULC changes over time using machine learning algorithms applied to multisource remotely sensed data in GEE, and (2) to assess the relationship between LULC changes and the extent of wetlands in the basin. A total of nine land cover classes were identified, including shrublands, croplands, bare-surface, wetlands, sparse vegetation, tree cover, built-up areas, and grasslands. Shrublands covered 76–82% of the LTRB. On the other hand, wetlands and sparse vegetation were the least dominant, with proportions ranging from 0.3 to 2%. The overall accuracy of the classification results was within acceptable ranges, ranging from 77 to 78%. The study further revealed a continuing decline in wetlands extent and sparse vegetation, with average rates of 19% and 44%, respectively. Conversely, shrublands, croplands, and tree cover showed an increase, with average rates of 0.4% and 12.4% respectively. A significant finding was the replacement of a substantial portion (40%) of wetland areas with built-up areas, indicating that urban expansion is a major driver of wetland shrinkage in the study area. These results provide valuable insights into the declining extent of wetlands in the LTRB. Such findings are crucial for environmental management efforts, as they provide information on which wetlands should be prioritized when implementing strategies to prevent the negative impacts of LULC changes on wetlands in the area. Therefore, contributing towards achieving sustainable development goals relating to freshwater ecosystems protection and management.
Monitoring microplastics in coastal waters of a biosphere reserve: a case study in Menorca (Spain)
Authors: Alomar Carme , Rios-Fuster Beatriz , Cefalì Maria Elena , Fagiano Valentina , Deudero Salud 
Published: November 2023

AbstractThis study provides with evidence of the presence of sea surface microplastics in a UNESCO marine biosphere reserve: the island of Menorca in the north-western Mediterranean Sea. From a total of 90 samples, in 100% of the samples, microplastics were observed with a mean value of 0.18 ± 0.01 items/m2. According to data, no significant differences were observed for sampling period with very similar values between 2021 (0.17 ± 0.02 items/m2) and 2022 (0.18 ± 0.02 items/m2). However, significant differences were observed regarding sampling area (both site and locality) suggesting that sea surface plastics in the study area might be more dependent of the spatial scale rather than on the temporal scale. Fibre type microplastics predominated over fragments, films, pellets, and foams, but in the commercial Port de Maó, almost 50% of the identified items were foams which could be related to the transportation of packed goods to this port. Results from the model applied to study the relation between waste management indicators and microplastic abundance indicate that when considering all marine litter categories, the explanatory variables are plastic waste generated by residents population (tonnes/year/km2) and waste collection rate (%), whereas if only plastics are considered, the indicator regarding waste per capita (kg/hab/year) is also included. Data in this study is obtained through a harmonized protocol which can be used to define baseline and threshold values to evaluate good environmental status regarding descriptor 10 of the Marine Strategy Framework Directive.
Biogenic ZnO/CuO/Fe2O3 Nanocomposite: A Groundbreaking Approach for Enhanced Degradation Capabilities and Reusability in Dye Removal Applications
Authors: Serouti Abdelghani , Eddine Laouini Salah , Meneceur Souhaila , Hasan Gamil Gamal , Mohammed Hamdi Ali , Salmi Chaima , Iman Kir , Ferhat Mohammed Fouad , Ali Ouarda Ben , Abdullah Johar Amin Ahmed 
Published: November 2023

AbstractWe present the successful synthesis of a biogenic ZnO/CuO/Fe2O3 nanocomposite using an aqueous leaf extract of Ocimum Basilicum L. The confirmation of biosynthesis was achieved through UV–Visible spectrophotometry (UV–Vis), which provided evidence of ZnO/CuO/Fe2O3 NC formation. Scanning Electron Microscopy further confirmed the nanoscale size of the NC, measuring at 65 nm. X-Ray Diffraction analysis revealed a hexagonal structure for ZnO and a monoclinic structure for CuO. The successful synthesis of the environmentally friendly ZnO/CuO/Fe2O3 NC was further verified using Fourier transformed infrared (FT-IR) spectroscopy, which identified the functional groups present in the composite. Notably, the ZnO/CuO/Fe2O3 NC demonstrated exceptional degradation capabilities for toluidine blue (TB), p-toluidine (PT), and m-Toluidine (MT), with degradation rates of 99%, 99.1%, and 99.7%, respectively, within a reaction time of 120 min. The reaction kinetics followed a pseudo-first order model, with rate constant (k) values of 0.0314 min−1 and 0.0189 min−1 for TB and PT, respectively. This high rate of dye degradation can be attributed to the low band gap of the NC, which was determined to be 1.44 eV for the indirect bandgap. Furthermore, the nanocomposite exhibited excellent degradation reusability, maintaining a high degradation rate in each cycle.
A multi-disciplinary approach for trap identification in the Southern Meleiha Area, North Western Desert, Egypt: integrating seismic, well log, and fault seal analysis
Authors: El-Qalamoshy Taha Rabea , Abdel-Fattah Mohamed I. , Reda Mohamed , Abdelhafeez Tharwat H. , Azzam Salah Shebl Saleh , Mosaad Mohamed 
Published: November 2023

AbstractThe southern Meleiha concession, situated within the development encouragement areas of the Agiba Petroleum Company between Matrouh Basin and Shushan basin, spans approximately 700 km2. This study examined late Cretaceous strata to improve trap identification in the Bahariya, Alamein Dolomite, and Alam El Bueib Members. This required a thorough study of 33 seismic lines and five well log records. Our investigations revealed the presence of hydrocarbons in the deep, mid, and shallow target zones, underscoring the significant potential of the Khatatba-Ras Qattara and Bahariya layers. The net pay thicknesses observed ranged from 12 to 43 feet, while effective porosity values fluctuated between 10 and 18%. Water saturation varied from 10 to 98%, while hydrocarbon saturation varied from 48 to 90%. Seismic interpretation revealed abundant normal faults in the study area, and our maps showed structural closures, including three-way and four-way dip closures, influenced by these faults. The shallowness of the Bahariya layer, coupled with Shally Sand facies intercalations in the upper target, makes it particularly susceptible to fault leakage, necessitating careful consideration when selecting drilling locations. Notably, the western half of our investigation area exhibited more Alam El Bueib Member net pay zones compared to the eastern and south-eastern regions. The geological structure of the deep-target Khatatba-Ras Qattara is of particular interest, revealing a total of 37 potential leads across all levels. These leads encompass destinations like Bahariya, Alam El-Bueib, and Khatatba formations, some of which may have dual targets, while others may focus on a single objective.
Inclusion Properties of the Triangular Ratio Metric Balls
Authors: Rainio Oona 
Published: November 2023

AbstractInclusion properties are studied for balls of the triangular ratio metric, the hyperbolic metric, the $$j^*$$

j
∗

-metric, and the distance ratio metric defined in the unit ball domain. Several sharp results are proven and a conjecture about the relation between triangular ratio metric balls and hyperbolic balls is given. An algorithm is also built for drawing triangular ratio circles or three-dimensional spheres.
Life Cycle Assessment as a Decision Tool in Material Development—Experiences from a Multi-year Carbon Fibre Composite Development Project
Authors: Hermansson Frida , Janssen Matty , Svanström Magdalena 
Published: November 2023

AbstractThis paper describes what type of advice life cycle assessment can provide in different parts of a material development project. Based on experiences from a multi-year research project aiming to decrease the environmental impacts of carbon fibre composites, we aim to show and discuss what type of input we could provide the material developers at different times. The goal is to guide life cycle assessment practitioners and material developers on what role life cycle assessment can play in various project parts. Cradle-to-gate data collected at different points in time throughout the project are compiled and recalculated to the same functional unit. Assessment results from all stages clearly show that even if the carbon fibres constitute a minor share of the composite, they are the environmental hotspot with considerable potential for improvements. Depending on the timing of the project, advice ranges from being careful with the source of nitrogen in the production process to using microwave heating in carbon fibre production. We recommend material developers to include life cycle assessment as early as possible in the project. We also recommend life cycle assessment practitioners continuously work with material developers in updating the models and inventory. Additionally, we recommend that life cycle assessment practitioners add more details to the assessment and expand the study’s foreground system as the project progresses. This could be done in combination with assessing the technology readiness level of the routes. By doing so, the life cycle assessment practitioner can provide material developers insight into potential routes worth developing. It also identifies the lowest-hanging fruits for reducing the materials’ environmental impact.
Graphical Abstract
Allene oxide synthase 1 contributes to limiting grain arsenic accumulation and seedling detoxification in rice
Authors: Fan Xin , Tang Haiyang , Chen Xuan , Zeng Fanrong , Chen Guang , Chen Zhong-Hua , Qin Yuan , Deng Fenglin 
Published: November 2023

AbstractArsenic (As) is a cancerogenic metalloid ubiquitously distributed in the environment, which can be easily accumulated in food crops like rice. Jasmonic acid (JA) and its derivatives play critical roles in plant growth and stress response. However, the role of endogenous JA in As accumulation and detoxification is still poorly understood. In this study, we found that JA biosynthesis enzymes Allene Oxide Synthases, OsAOS1 and OsAOS2, regulate As accumulation and As tolerance in rice. Evolutionary bioinformatic analysis indicated that AOS1 and AOS2 have evolved from streptophyte algae (e.g. the basal lineage Klebsormidium flaccidum) – sister clade of land plants. Compared to other two AOSs, OsAOS1 and OsAOS2 were highly expressed in all examined rice tissues and their transcripts were highly induced by As in root and shoot. Loss-of-function of OsAOS1 (osaos1–1) showed elevated As concentration in grains, which was likely attributed to the increased As translocation from root to shoot when the plants were subjected to arsenate [As(V)] but not arsenite [As (III)]. However, the mutation of OsAOS2 (osaos2–1) showed no such effect. Moreover, osaos1–1 and osaos2–1 increased the sensitivity of rice plants to both As(V) and As(III). Disrupted expression of genes involved in As accumulation and detoxification, such as OsPT4, OsNIP3;2, and OsOASTL-A1, was observed in both osaos1–1 and osaos2–1 mutant lines. In addition, a As(V)-induced significant decrease in Reactive Oxygen Species (ROS) production was observed in the root of osaos1–1 but not in osaos2–1. Taken together, our results indicate OsAOS1 modulates both As allocation and detoxification, which could be partially attributed to the altered gene expression profiling and ROS homeostasis in rice while OsAOS2 is important for As tolerance.
Combinatorial Alloy Design and Microstructure Evolution in Laser-cladded Al–Co–Cr–Fe–Ni–Ti Compositionally Complex Alloys
Authors: Kaspar J. , Hilhorst A. , Gerdt L. , Müller M. , Heidowitzsch M. , Kuczyk M. , Bettanini A. M. , Jacques P. J. , Zimmermann M. , Leyens C. 
Published: November 2023

AbstractIn this work, we propose a strategy for high-throughput design and development of compositionally complex alloys combining theoretical and experimental alloy screening. This methodology was applied for the exploration of the (Co2CrFeNi2)1-x-yTixAly subsystem of so-called high entropy superalloys in the Al–Co–Cr–Fe–Ni–Ti alloy system. Alloy design was guided by thermodynamic calculations based on the CALPHAD approach. The evolution of the microstructure with increasing Al and Ti content was analyzed in the as-built, homogenized and age-hardened conditions by means of scanning electron microscopy, energy-dispersive X-ray spectroscopy and electron backscattered diffraction. Additionally, the evolution of the sample hardness with increasing Al and Ti contents was determined for all conditions. Based on the experimental results, the reliability of the CALPHAD calculations was assessed. Generally, a good agreement between calculations and experiments is achieved in the homogenized state. In the aged conditions, the CALPHAD predictions of the precipitation processes are partly inaccurate and need improvement. Optimal Al and Ti concentrations are derived for age hardening through L12 and combined L12 + B2 precipitations.