bluuebunny/crossref_metadata_2025_split huggingface dataset:
Enhanced Nonlinear Optical Susceptibilities of Semiconductor Quantum Dot in Metal Nanoparticle-Graphene Nanodisk-Quantum Dot Hybrid System
Authors: Maleki Zeynab , Naseri Tayebeh 
Published: December 2023

Abstract

In this paper, we have theoretically explored the third-order and fifth-order nonlinear susceptibilities for a semiconductor quantum dot in a hybrid system composed of a semiconductor quantum dot, metal nanoparticle, and graphene nanodisk. We considered the dipole-dipole interaction induced by the applied field assuming continuous-wave electromagnetic field enhancement in the quantum dot. The semiconductor quantum dot in the MNP-SQD-GND hybrid system exhibits analytically obtained third- and fifth-order susceptibilities, which are described by means of the density matrix approach. As a function of the applied field frequency detuning, we were able to obtain the spectra of the third- and fifth-order susceptibilities for a variety of parameters, including the metal nanoparticle radius, material, orientation, and arrangement within the hybrid system, as well as the interparticle angles and distances. Additionally, we looked into the effects of having the graphene nanodisk present or absent. The outcomes showed that there was a considerable variation in the semiconductor quantum dot's nonlinear optical response when each of these factors was changed. In particular, the presence of the graphene nanodisk led to a substantial enhancement in the nonlinear optical response of the quantum dot in this hybrid system influenced by the dipole-dipole interaction. The results suggest an increased nonlinearity of the semiconductor quantum dot within this hybrid system.
Auxiliary occlusal devices for IO scanning in a complete digital workflow of implant- supported crowns: A randomized controlled trial
Authors: Ren Shuxin , Jiang Xi , Di Ping 
Published: December 2023

Abstract
Objectives: To compare the crown accuracy and time efficiency of a complete digital workflow, utilizing an auxiliary occlusal device and IO scanning, with a conventional workflow, for multiple implant-supported single crowns.
Materials and Methods: 24 patients with two adjacent posterior implants were included. 12 patients were randomly assigned to digital workflow group, involving intra-oral scanning with an auxiliary occlusal device and manufacture of customized abutments and zirconia single crowns (test group). The other 12 were assigned to the conventional workflow (control group), involving conventional impression and CAD-CAM crowns based on stone casts. Crown scanning was done before and after clinical adjustment using an intraoral scanner. Two 3D digital models were overlapped to assess dimension changes. Chair-side and laboratory times for the entire workflow were recorded and a linear mixed model and Independent-sample t tests were used for the statistical analysis.
Results: The maximum occlusal deviation was 279.67±112.17 µm and 479.59±203.63 µm in the test and control group, respectively (p < .001). The sizes of the occlusion adjustment areas were 12.12±10.51 mm2 and 25.12±14.14 mm2 in the test and control groups, respectively (p = 0.013). The mean laboratory time was 46.08 ± 5.45 and 105.92 ± 6.10 min in the test and control groups, respectively (p < 0.001).The proximal contact adjustment and mean chair-side time showed no statistically significant difference between two groups.
Conclusions: A digital workflow for two implants-supported single crowns using an auxiliary device required fewer occlusal crown adjustments, and less laboratory time compared to conventional workflow.
Clinical Relevance: The use of auxiliary occlusal devices in IOS enhances the accuracy of virtual maxillomandibular relationship in extended edentulous spans. Consequently, employing a digital workflow for multiple implants-supported crowns using IO scanning and an auxiliary occlusal device proves to be a feasible, accurate and efficient approach.
Diversity and function of rhizosphere microorganisms in medicinal plant Polygonatum cyrtonema Hua
Authors: Zhou Duanxu , Sun Yingying , Hou Jing , Liu Haiyan 
Published: December 2023

Abstract
In China, Polygonatum cyrtonema Hua (Huangjing) is known for its medicinal and edible properties. Multiple environmental factors can shape plant-microbiome interactions. The cultivated sample sites were enriched characteristic fungi by Clonostachys divergens and Archaeorhizomycetes spp. whereas wild sample sites were enriched particular by Geminibasidium spp. and Bifiguratus spp. The number of observed species was lower in cultivated soil samples compared with wild ones by alpha diversity analysis. Functional annotation showed that the xylanolysis metabolism pathway was more abundant in rhizosphere microorganisms of cultivated P. cyrtonema Hua. The co-occurrence network showed positively interacted between Mucoromycota and Rozellomycota in the cultivated rhizosphere soil. Moreover, this result indicated that biomass of cultivated plant was significantly greater than that of the wild samples, and the polysaccharide content of the cultivated rhizomes was higher. In this study, we may predict basic and potential microbes that beneficial for the P. cyrtonema Hua rhizosphere improve the productivity and quality.
Subgroups of perceived professional preparedness of senior nursing students and their differences in professional identity: a latent profile analysis
Authors: qin zuming , Zhang Huilin , Su Siyu , Guo Donghua , Wu Pei , Huang Yuting , Wang Huiping 
Published: December 2023

Abstract

Background
Senior nursing students’ perceptions of their professional preparedness help them perform their nursing role confidently and independently in the future. Therefore, it is critical to both identify the classification features of perceived professional preparedness and develop targeted interventions. Professional identity (PI) may contribute to cultivating the nursing students’ perceptions of professional preparedness, but the relationship between the two is unclear currently. This study aims to explore the subgroups of senior nursing students’ perceptions of professional preparedness and their differences in PI.
Method
This was a cross-sectional study. A total of 319 senior nursing students from five universities in China were enrolled. The Perceived Professional Preparedness of Senior Nursing Students’ Questionnaire (PPPNS) and the Professional Identity Scale for Nursing Students (PISNS) were adopted. Latent profile analysis (LPA) was used to analyze the latent profiles of perceived professional preparedness among senior nursing students. Multiple logistic regression was applied to explore the predictors of different profiles, and a one-way analysis of variance was conducted to compare the PI scores in each latent profile.
Result
Three latent profiles were identified and labeled “low perceived professional preparedness” (n = 90, 28.2%), “low clinical competency-low EBP(Evidence-Based Practice)” (n = 190, 59.5%) and “high perceived professional preparedness” (n = 39, 12.2%). The “low perceived professional preparedness” group was less likely to include those senior nursing students who worked more than 7 hours per day during the clinical practicum, resided in town and urban areas, had part-time experience, had good relationships with classmates, and felt nobility to nursing due to the COVID-19 pandemic. The average PI score was statistically different across the three profiles (F = 54.69, p < 0.001).
Conclusion
Promoting PI may effectively cultivate the perceived professional preparedness of senior nursing students. This study highlights the importance of targeted interventions by considering their distinct perceptions of professional preparedness patterns.
Stochastic modeling of an influenza A model with logarithm Ornstein–Uhlenbeck process
Authors: Zhang Xiaoshan , Zhang Xinhong 
Published: December 2023

Abstract

We consider an influenza A epidemic model that incorporates vaccination and asymptomatic patients and investigate its dynamics. The stability analysis of the equilibria in the deterministic model is conducted using the Routh-Hurwitz stability criterion. To account for the significant impact of environmental disturbance on disease transmission, the transmission rate is modeled as a logarithm Ornstein-Uhlenbeck process, resulting in a stochastic model. The existence of the unique global positive solution in the model is verified, and Lyapunov functions are employed to establish sufficient conditions for the presence of a stationary distribution. The paper also examines the conditions for the extinction or persistence of asymptomatic and infected individuals. Lastly, an exact expression for the probability density function of the stochastic model near the quasi-equilibrium is derived, and numerical simulations are performed to support the proposed theoretical findings.
Randomized evaluation of 5-month Ticagrelor monotherapy after 1-month dual-antiplatelet therapy in patients with acute coronary syndrome treated with drug-coated balloons: REC-CAGEFREE II trial rationale and design
Authors: Gao Chao , Zhu Bin , Liu Jianzheng , Jiang Zhiwei , Hu Tao , Wang Qiong , Liu Yi , Yuan Ming , Li Fei , Zhang Ruining , Xia Jielai , Onuma Yoshinobu , Wang Duolao , Serruys Patrick , Tao Ling 
Published: December 2023

Abstract
Background
Patients treated with drug-coated balloons (DCB) have the theoretical advantage of adopting a low-intensity antiplatelet regimen due to the absence of struts and polymers. Nevertheless, the optimal antiplatelet strategy for patients undergoing DCB-only treatment remains a topic of debate and has not been investigated in randomized trials.
Methods
The REC-CAGEFREE II is an investigator-initiated, prospective, open-label, multi-center, randomized, non-inferiority trial aimed to enroll 1908 patients from ≥ 40 interventional cardiology centers in China to evaluate the non-inferiority of an antiplatelet regimen consisting of Aspirin plus Ticagrelor for one month, followed by five months Ticagrelor monotherapy, and then Aspirin monotherapy for six months (Experimental group) compared to the conventional treatment of Aspirin plus Ticagrelor for 12 months (Reference group) in patients with acute coronary syndrome (ACS) who have undergone percutaneous coronary intervention (PCI) using paclitaxel-coated balloons (DCB) exclusively. Participants will be randomly assigned to the Experimental or Reference group in a 1:1 ratio. The randomization will be stratified based on the center and the type of lesion being treated (De novo or in-stent restenosis). The primary endpoint is net adverse clinical events (NACE) within 12 months of PCI, which includes the composite of all-cause death, any stroke, any myocardial infarction, any revascularization and Bleeding Academic Research Consortium (BARC) defined type 3 or 5 bleeding. The secondary endpoint, any ischemic and bleeding event, which includes all-cause death, any stroke, MI, BARC-defined type 3 bleeding, any revascularization, and BARC-defined type 2 bleeding events, will be treated as having hierarchical clinical importance in the above order and analyzed using the win ratio method.
Discussion
The ongoing REC-CAGEFREE II trial aims to assess the efficacy and safety of a low-intensity antiplatelet approach among ACS patients with DCB. If non-inferiority is shown, the novel antiplatelet approach could provide an alternative treatment for ACS patients with DCB.
Trial registration:
ClinicalTrials.gov identifier: NCT04971356
Asthma and Cardiovascular Diseases: A Mendelian Randomization Study
Authors: Zhao yibin , Xu fu 
Published: December 2023

Abstract
Background: A few of cohort studies declared a positive association between asthma and cardiovascular diseases, but the causal relationship is ambiguous.
Objective: To evaluate the causal relationship between asthma, and cardiovascular diseases.
Methods: We adopted a two-sample Mendelian randomization (MR) analysis, based on inverse variance weighting as the dominate method. Besides, we calculated effect estimates by using random-effects inverse-variance weighting method.
Results：We found that the suggested proof of a postive association between asthma and two of ten cardiovascular diseases, including type 2 diabetes (OR = 1.09; 95% CI, 1.00–1.17; p=0.038), and atrial fibrillation (OR = 1.06; 95% CI, 1.01–1.10; p=0.011). No associations were discovered for coronary heart disease, hypertension, heart failure, transient ischemic attack, ischemic stroke, pulmonary embolism, peripheral artery disease, and myocardial infarction.
Conclusions: A suggestive causal connection between asthma and the risk of type 2 diabetes or atrial fibrillation can be indicated in our research. Any convincing evidence had been failed to find to suggest that asthma is causally related to the risk of other cardiovascular diseases.
Depletion of placental brain-derived neurotrophic factor (BDNF) is attributed to premature ovarian insufficiency (POI) in mice offspring
Authors: Liu Bin , Liu Yongjie , Li Shuman , Chen Pingping , Zhang Jun , Feng Liping 
Published: December 2023

Abstract
Introduction
Premature ovarian insufficiency (POI) is one of the causes of female infertility. Unexplained POI is increasingly affecting women in their reproductive years. However, the etiology of POI is diverse and remains elusive. We and others have shown that brain-derived neurotrophic factor (BDNF) plays an important role in adult ovarian function. Here, we report on a novel role of BDNF in the Developmental Origins of POI.
Methods
Placental BDNF knockout mice were created using CRISPR/CAS9. Homozygous knockout (cKO(HO)) mice didn't survive, while heterozygous knockout (cKO(HE)) mice did. BDNF reduction in cKO(HE) mice was confirmed via immunohistochemistry and Western blots. Ovaries were collected from cKO(HE) mice at various ages, analyzing ovarian metrics, FSH expression, and litter sizes. In one-month-old mice, oocyte numbers were assessed using super-ovulation, and oocyte gene expression was analyzed with smart RNAseq. Ovaries of P7 mice were studied with SEM, and gene expression was confirmed with RT-qPCR. Alkaline phosphatase staining at E11.5 and immunofluorescence for cyclinD1 assessed germ cell number and cell proliferation.
Results
cKO(HE) mice had decreased ovarian function and litter size in adulthood. They were insensitive to ovulation induction drugs manifested by lower oocyte release after superovulation in one-month-old cKO(HE) mice. The transcriptome and SEM results indicate that mitochondria-mediated cell death or aging might occur in cKO(HE) ovaries. Decreased placental BDNF led to diminished primordial germ cell proliferation at E11.5 and ovarian reserve which may underlie POI in adulthood.
Conclusion
The current results showed decreased placental BDNF diminished primordial germ cell proliferation in female fetuses during pregnancy and POI in adulthood. Our findings can provide insights into understanding the underlying mechanisms of POI.
Efficacy and safety of camrelizumab combined with chemotherapy for the treatment of HER2-negative advanced gastric cancer
Authors: Lian Mingjie , Cai Yichen , Lian Mingqiao , Sun Yuqin , Xu Qianhui , Chen Qiuxian , Cai Lisheng 
Published: December 2023

Abstract
Background: The first-line treatment for patients with HER2-negative advanced gastric cancer is mainly chemotherapy. Immunotherapy combined with chemotherapy has achieved encouraging results in many prospective studies, but its real-world efficacy has not yet been fully clarified. The aim of this study was to use independent sample data to explore the efficacy and safety of immunotherapy for patients with HER2-negative gastric cancer.
Methods: This study included 59 patients with HER2-negative advanced gastric cancer who received camrelizumab immunotherapy combined with chemotherapy or chemotherapy alone from April 2019 to November 2021. The endpoints were the objective response rate (ORR), disease control rate (DCR), progression-free survival (PFS), overall survival (OS), and safety.
Conclusion: Compared with simple chemotherapy treatment, camrelizumab combined with chemotherapy for the first-line treatment of HER2-negative advanced gastric cancer has significant clinical benefits without increasing treatment-related complications, and it is safe and feasible.
Lithium Carbonate Alleviate Neuronal Apoptosis to Improve Depression Symptoms in Mice by the JNK/c-Jun Signaling Pathway
Authors: Jin Weidong , Jin Haiying , Liu Jie , Chen Fengpei , Fengli Sun 
Published: December 2023

Abstract
Objective
Lithium is a monovalent cation that was introduced in 1949 by John Cade for the treatment of bipolar disorder，especially for mania.As for mood stabilizer, it should be effective in treatment of depression.To explore lithium alleviate the apoptosis of nerve cells through JNK/ C-Jun signaling pathway and improve the depressive symptoms in depressed mice.
Methods
30 male mice were randomly divided into blank control(control) , model group(stress) and drug intervention group(stress+lithium). A model of depression was established by Chronic unpredictable mild stress (CUMS). Mice in stress+lithium group were given lithium from 4th weekend. The behavior of mice were evaluated and Western blot was used to detect expression levels of related proteins.
Results
Compared with control, stress+lithium group showed a significant decrease depressive symptoms (P< 0.01).Western blotting results show that compared with stress group, protein levels of P-JNK /JNK ,P-C-Jun/C-Jun ,caspase-3 and Bax in PFC of control were significantly increased (P < 0.01), Bcl-2 level significantly decreased (P < 0.01);Compared with the stress group, the protein levels of nerve cells p-JNK/JNK, P-C-Jun/C-Jun, aspase-3 and Bax in prefrontal cortex of mice in stress +lithium group were significantly decreased (P< 0.01), Bcl-2 level increased significantly (P < 0.01).
Conclusions Lithium improve depression symptoms by reducing apoptosis of prefrontal cortex nerve cells through JNK/ C-Jun signaling pathway in depressive mice.
Nutrition-immune-inflammation score (NIIS) plays an important role in the prognosis of postoperative external auditory canal carcinoma patients
Authors: Cheng Hao , Xu Jin-Hong , Li Yi-Hao , Wang Jing-Jing , Hao Meng-Di , He Jia-Qi , Xu Xue-Lian 
Published: December 2023

Abstract
Background
External auditory canal carcinoma (EACC) was a rare malignant tumor. This study aimed to investigate the influence of the comprehensive index of nutrition-immune-inflammation score (NIIS) on the prognosis of EACC patients with surgical resection.
Methods
A total of 45 EACC patients with surgical resection were selected from two tertiary medical institutions, and were diagnosed between July 2012 and May 2018. NIIS was calculated by integrating the values of body mass index (BMI), C-reactive protein (CRP), lymphocytes, albumin, and hemoglobin. The relationship between NIIS and prognosis was analyzed by a Log-rank test and displayed by Kaplan-Meier plot.
Result
The 3- and 5-year survival rate for EACC patients with surgical resection were 70.7%, 61.3% for OS, and 55.6%, 51.1% for PFS, respectively. Most patients with EACC have a nutrition-immune-inflammation score (NIIS) of 4–5 (44.4%). EACC patients with a high score of NIIS tend to have poorer OS (P = 0.001) and PFS (P < 0.001) in comparison with a low score of NIIS. Only a small minority of patients with EACC accept adjuvant radiotherapy (37.8%), and adjuvant chemotherapy (15.6%). Adjuvant radiotherapy had benefit in improving the OS for EACC patients with surgical resection (P = 0.027). However, the adjuvant treatment had no benefit for PFS in postoperative EACC patients (P > 0.05).
Conclusion
NIIS is an important predictor for predicting the prognosis of EACC patients with surgical resection. Adjuvant radiotherapy was recommended in the application of EACC patients with surgical resection, but not adjuvant chemotherapy. Our findings would have a vital effect on treatment choice and clinical management for both EACC patients and clinicians.
Multi-Threshold Image Segmentation Research Based on Improved Enhanced Arithmetic Optimization Algorithm
Authors: Li Hanyu , Zhu Xiaoliang , Li Mengkun , Yang Ziwei , Wen Mengke 
Published: December 2023

Abstract
To address the disadvantages of low efficiency, slow convergence speed and easy to fall into local optimal of arithmetic optimization algorithm (AOA), this paper proposes an improved arithmetic optimization algorithm, called IAOA, and applies it to multi-threshold image segmentation processing. Compared with the original algorithm, the improvements are: first, inertia weight and cosine factor are introduced to AOA to enhance algorithm stability; then chaotic mapping is embedded in the algorithm selection stage to accelerate convergence speed; finally, Cauchy mutation and reverse learning strategies are introduced to avoid the algorithm falling into local optimal. This paper uses 23 benchmark functions in CEC-2005 to test the performance of the IAOA, and selects 8 commonly used image segmentation performance indicators and 3 image quality indicators to detect the image segmentation effect of the IAOA. In addition, several classic metaheuristic algorithms are selected for comparison. The results show that compared with other algorithms, the IAOA has stronger robustness and better segmentation performance.
Characteristics of early gastric cancer in a previous Helicobacter pylori infection with no history of eradication therapy
Authors: Kuraoka Sakiko , Kawano Seiji , Ino Shoko , Satomi Takuya , Hamada Kenta , Kono Yoshiyasu , Iwamuro Masaya , Kawahara Yoshiro , Tanaka Takehiro , Okada Hiroyuki , Otsuka Motoyuki 
Published: December 2023

Abstract
Background
The characteristics of gastric cancer in patients with atrophic mucosa without apparent history of Helicobacter pylori eradication have not been thoroughly investigated. Thus, this study aims to examine the clinicopathological characteristics of gastric cancer in these patients.
Methods
We examined endoscopic and pathological characteristics of gastric cancer in two groups of patients: those with gastric atrophy and no history of eradication (group A; n = 102) and those with a history of eradication (group B; n = 161). In group A, patients were further divided in terms of mild atrophy (group C) and severe atrophy (group D), while group B was further divided into those who underwent eradication treatment > 5 years ago (group E) and those who underwent eradication 1–5 years ago (group F).
Results
Group A comprised significantly older individuals (76 ± 8.2 vs. 71 ± 7.4 years, p < 0.001) with a higher frequency of elevated-type gastric cancer than that of patients in group B (32.4% vs. 17.4%, p = 0.006). Compared with group E, group A showed an older age and a greater incidence of elevated-type gastric cancer. The incidence of gastric cancer in U or M region was lower in group C than in group D.
Conclusions
Gastric cancer in patients with gastric atrophy and no history of eradication was associated with older age and a higher frequency of the elevated-type morphology than in those with a history of eradication. Endoscopists should be vigilant in detecting elevated-type gastric cancer in this particular population.
Efficiency Analysis of Discontinuous Galerkin Approaches for the Application Onto Quantum-Liouville Type Equations
Authors: Ganiu Valmir , Schulz Dirk 
Published: December 2023

Abstract

The simulation of nano devices is computationally inefficient with current algorithms. The discontinuous Galerkin approach has been demonstrated in the field of computational fluid dynamics to deliver high order accuracy and efficiency due to its reliance on matrix-vector multiplications. The discontinuous Galerkin approach was previously successfully used in conjunction with the Finite Volume technique to solve the Liouville-von Neumann equation in center-mass coordinates and thus simulate nano devices. To exploit its full potential regarding high performance computing, this work aims to substitute the aforementioned Finite Volume technique with the discontinuous Galerkin method. To arrive at the said formalism, a Finite Element method is implemented as an intermediate step.