bluuebunny/crossref_metadata_2025_split huggingface dataset:
Psilocybin does not induce the vulnerability marker HSP70 in neurons susceptible to Olney’s lesions
Authors: Iorgu Ana-Maria , Vasilescu Andrei-Nicolae , Pfeiffer Natascha , Spanagel Rainer , Mallien Anne Stephanie , Inta Dragos , Gass Peter 
Published: November 2023

AbstractS-ketamine, a N-methyl-D-aspartate receptor (NMDAR) antagonist, and psilocybin, a 5-hydroxy-tryptamine (serotonin) 2A receptor (5-HT2AR) agonist, are reported as effective rapid-acting antidepressants. Both compounds increase glutamate signalling and evoke cortical hyperexcitation. S-ketamine induces neurotoxicity especially in the retrosplenial cortex (Olney’s lesions). Whether psilocybin produces similar neurotoxic effects has so far not been investigated. We performed an immunohistochemical whole-brain mapping for heat shock protein 70 (HSP70) in rats treated with psilocybin, S-ketamine, and MK-801. In contrast to S-ketamine- and MK-801-treated animals, we did not detect any HSP70-positive neurons in retrosplenial cortex of rats treated with psilocybin. Our results suggest that psilocybin might be safer for clinical use compared to S-ketamine regarding neuronal damage.
A Functional approach for constructing dynamic Composite Indicators
Authors: Sarra Annalina , Nissi Eugenia , Evangelista Adelia , Di Battista Tonio 
Published: November 2023

AbstractThis paper contributes to the research on the development of comparable composite indicators by introducing a Functional Weighted Malmquist Productive Index that allows for comparative trend analysis. In analogy with entropy-based weighted methods, this novel dynamic indicator is derived by measuring the degree of diversification of the single method through a family of diversity indices. The paper has the merit of proposing a new dynamic composite indicator that supplements the analysis with Functional Data Analysis (FDA) tools that provide us with useful information about the order and dynamics of the composite index trajectories. The simulation study set up in this paper raises doubts about the robustness of the entropy-based weighted methods while the application of the new index to well-being dataset highlights its practical appeal.
Genetic diversity of Citrullus colocynthis populations using phytochemical analysis and SCoT marker variations
Authors: Badr Abdelfattah , Zaki Hoida 
Published: November 2023

AbstractCitrullus colocynthis L. Schard (bitter melon) is a drought-resistant medicinal plant growing in Egypt and many other countries in the arid environments of the World. In Egypt, it is abundant in several locations in Egypt's Eastern Desert, extending from the Nile River eastward to the Red Sea, particularly in the Kosseir region on the Red Sea coast. It has a wide range of applications in traditional medicine due to its anti-inflammatory, antibacterial, antioxidant, and anesthetic features. In this study, the genetic diversity was explored using chemical analysis of the secondary metabolites in seed extract in 15 populations from different sites in the Eastern Desert of Egypt to correlate the chemical variation with genetic differences among populations as revealed by DNA fingerprinting using the Start Codon Targeted (SCoT) markers. A total of 81 chemical compounds were identified from the 15 populations. Retention time, peak area percentage, molecular weight, and chemical formula were determined for each compound. Ten SCoT primers produced 137 bands in the 15 populations of these; 85 bands were polymorphic, 50 were monomorphic, and two bands were unique to a single population. Populations located in the southern part of the Eastern Desert have similar levels of phytochemical and genetic diversity and are differentiated from populations in the northern part. On the other hand, populations in the middle part show a small resemblance to other populations in the north and south, indicating an impact of the ecology on the genetic differentiation and the chemical composition of the secondary metabolites in C. colocynthis.
Does Having a Sibling Affect Autistic People's Empathy?
Authors: Rum Yonat , Golan Ofer , Allison Carrie , Smith Paula , White Simon R. , Baron-Cohen Simon 
Published: November 2023

AbstractThis study examined whether autistic people with siblings score higher on measures of empathy than those without siblings. Cohorts of autistic children (n = 939; mean age = 7.35 years (SD = 2.15)) and autistic adults (n = 736; mean age = 37 years (SD = 12.39)) from the Cambridge Autism Research Database (CARD) were each divided into two groups: with or without siblings. Empathy was measured using the children version of the Empathy Quotient (EQ) (parent-report) for children. For adults, the EQ (self-report version) and the Reading the Mind in the Eyes Test (RMET) were used. Contrary to the hypothesis, autistic children without siblings scored higher on EQ than those with siblings (t(283.70) = 4.20, p < .001; d = 0.50). In adults, there was no difference between autistic adults with and without siblings on both measures, but there was an interaction effect between sex and group on the RMET (f(1732) = 4.10, p = 0.04): whilst autistic males without siblings on average scored lower than females, autistic males with siblings on average performed similarly to females. Future research should investigate the possible effect of siblings on autistic males' empathy performance in a larger cohort of autistic individuals. Children's empathic abilities may be underestimated by their parents when they have siblings due to a contrast effect.
Identifying a green infrastructure to prioritise areas for restoration to enhance the landscape connectivity and the provision of ecosystem services
Authors: Ortega Unai , Ametzaga-Arregi Ibone , Sertutxa Unai , Peña Lorena 
Published: November 2023

Abstract
Introduction
Habitat fragmentation is one of the major causes of the loss of biodiversity that our planet is experiencing. This has affected the ecosystems functioning and, consequently, the provision of ecosystem services (ES). Therefore, the European Commission, in a 2013 communication, established the concept of Green Infrastructure (GI), which is a strategically planned network of multifunctional areas with the aim of protecting biodiversity and ES supply, as well as improving ecological connectivity. Ecological restoration is an essential element to achieve the objectives of the GI, which if well targeted, could reverse widespread ecosystem degradation and improve landscape connectivity.

Objective
In this study, we propose a methodology to prioritise areas to restore by identifying a GI in the Urdaibai Biosphere Reserve (UBR), in the north of the Iberian Peninsula, where forest plantations of exotic species abound.

Methods
In order to identify the elements of the GI (core areas and corridors) we integrated a multispecies approach based on the movement of key species and an ES-based approach based on multifunctionality. Subsequently, to prioritise areas to restore we identified sectors in the GI, where connectivity is particularly vulnerable (pinch points) using the circuit theory. Thus, forest plantations around the pinch points were prioritised for a future restoration plans depending on their aim: (1) Improve corridors of high importance and low quality for the multispecies approach (2) Improve corridors of high importance and low quality for the ES-based approach, and (3) Improve the connectivity of the GI for the species movement.

Results
The resultant GI included 36% of the UBR surface. We identified 34 pinch points for the corridors of the three especies in the multispecies approach and 64 in the ES-based approach. We prioritised 149 ha of exotic forest plantations around the pinch points to convert into native forest in order to improve the corridors and 167 ha to improve GI connectivity.

Conclusion
This information could be useful for organizations and institutions carrying out restoration actions for the recovering of native forests in the territory.
The untapped potential of actinobacterial lanthipeptides as therapeutic agents
Authors: Ramírez-Rendón Dulce , Guzmán-Chávez Fernando , García-Ausencio Carlos , Rodríguez-Sanoja Romina , Sánchez Sergio 
Published: November 2023

AbstractThe increase in bacterial resistance generated by the indiscriminate use of antibiotics in medical practice set new challenges for discovering bioactive natural products as alternatives for therapeutics. Lanthipeptides are an attractive natural product group that has been only partially explored and shows engaging biological activities. These molecules are small peptides with potential application as therapeutic agents. Some members show antibiotic activity against problematic drug-resistant pathogens and against a wide variety of viruses. Nevertheless, their biological activities are not restricted to antimicrobials, as their contribution to the treatment of cystic fibrosis, cancer, pain symptoms, control of inflammation, and blood pressure has been demonstrated. The study of biosynthetic gene clusters through genome mining has contributed to accelerating the discovery, enlargement, and diversification of this group of natural products. In this review, we provide insight into the recent advances in the development and research of actinobacterial lanthipeptides that hold great potential as therapeutics.
Ecological, morphological and phylogenetic survey of Fomes fomentarius and F. inzengae (Agaricomycetes, Polyporaceae) co-occurring in the same geographic area in Central Europe
Authors: Tomšovský Michal , Kaeochulsri Sirapitcha , Kudláček Tomáš , Dálya László Benedek 
Published: November 2023

AbstractThe phenomenon of cryptic species is widespread among various fungal lineages. Fomes inzengae (Ces. & De Not.) Cooke has been recently recognized as a South European kin of wood-decay basidiomycete F. fomentarius (L.) Fr. due to the problematic morphological identification of both species, their taxonomic status has been disputed. The aim of this research is to examine the distribution, host preferences, morphological characters, and phylogenetic relationships between F. fomentarius and F. inzengae in the South Moravian region in Czechia (Central Europe), where both species occur sympatrically. The results revealed the ecological preferences of Fomes spp. along an altitudinal gradient, while F. inzengae is a lowland taxon, F. fomentarius dominates at higher altitudes in forests with abundant Fagus sylvatica. The main contact zone of the two taxa is located in the upper-colline vegetation belt (elevation ca. 400‒550 m a.s.l.). The morphological analysis revealed that the basidiospore size, the width of skeletal hyphae in basidiomes, and the linear density of pores of both taxa are almost identical and can not be used for the identification of the two species. Multigene sequence analyses of ITS, LSU, RPB1, RPB2, and TEF1 markers confirmed that F. fomentarius and F. inzengae are phylogenetically distinct species. The relationship of F. inzengae and F. fomentarius to Globifomes graveolens and Hexagonia spp. is discussed.
Produktivistische Ökologie: Der Energiebegriff der klassischen Moderne und seine Implikationen für eine kritische Soziologie
Authors: Russ Daniela 
Published: November 2023

ZusammenfassungDiverse ökologisch orientierte Entwürfe der jüngeren soziologischen Theorie betrachten die Moderne als eine Gesellschaftsform, für die eine strikte Trennung von Natur und Gesellschaft konstitutiv ist. Nicht selten schließt sich daran die Forderung an, diese Trennung durch Einsicht in Kontinuitäten zu unterlaufen. Anhand einer Rekapitulation des modernen Diskurses um den Begriff der Energie zeigt der Artikel dagegen, dass die Vorstellung der Moderne als anti-ökologische Gesellschaftsform zu kurz greift: Sie unterschlägt, dass das „Herausarbeiten“ des modernen Menschen aus der Natur immer auch bedeutete, Gesellschaft selbst als naturbedingt, bisweilen gar als natürliche, zu begreifen. In einer historisch-soziologischen Analyse der Energiewirtschaft wird daran anschließend gezeigt, dass diese zwar eine reale Trennung zwischen natürlicher und menschlicher Arbeit vollzieht und verdinglicht, dabei jedoch eine darunterliegende Verbundenheit unterstellt. Denn die Realisierung dieser Trennung beruht geradenichtauf der Vorstellung, Gesellschaft sei das Andere der Natur. Vielmehr folgten Wissenschaftler und Ingenieure der klassischen Moderne einer „produktivistischen Ökologie“, der zufolge Gesellschaft erst in ihrer energetischen Gattungsentwicklung zu ihrer natürlichen Bestimmung findet. Diese Vorstellung verliert seit den 1970er-Jahren an Überzeugungskraft. Wenn aber die ökologische Frage heute nicht nur in der Geschichte gescheiterter Trennungen, sondern auch in der Geschichte einer ökologischen Bestimmung des menschlichen Lebenszwecks steht, so das Resümee, dann bedarf es neben einer Kritik des ökologischen Denkens womöglich auch eines positiven Begriffs von energetischer Verdinglichung.
Fasciola Infection Unexpectedly Found During Cholecystectomy: Review on How to Avoid Increasing Surgery Interventions in Non-human Endemic Areas
Authors: Mowlavi Gholamreza , Bargues María Dolores , Najafi Faezeh , Naddaf Saied Reza , Salehabadi Alireza , Vejdan Amir Kazem , Salimi Mahboobeh , Fadavi Arezoo , Arab-Mazar Zahra , Mas-Coma Santiago 
Published: November 2023

Abstract
Purpose
Fascioliasis is caused by Fasciola hepatica of almost worldwide distribution and F. gigantica in wide regions of Asia and Africa. Their adult stage develops in the biliary canals and gallbladder. Infection follows an initial, 3–4 month long invasive, migratory or acute phase, and a several year-long biliary, chronic or obstructive phase.

Methods
The unexpected finding of a fasciolid inside the gallbladder during a cholecystectomy for obstructive lithiasis suspicion in a patient is reported from an area of Iran where human infection had been never reported before and studies on fascioliasis in livestock are absent.

Results
The fluke obtained was phenotypically classified as F. hepatica by morphometry and genotypically as F. gigantica by mtDNA cox1 fragment sequencing, although with F. hepatica scattered mutations in species-differing nucleotide positions. The clinical, radiological, and biological signs observed at the acute and chronic phases often lead to some misdiagnosis. Serological methods may be useful in cases of negative coprology. Diagnostic techniques with insufficient resolution leading to unnecessary invasive interventions are analyzed. The way to avoid unnecessary surgery is described, including analyses to be made, diagnostic tools to be used, and aspects to be considered.

Conclusion
Reaching a correct diagnosis in the confusing presentations avoids procedure delays and unnecessary surgery. A correct drug treatment may be sufficient. Except in extreme pathological presentations, lesions decrease in number and size and finally disappear or calcify after a successful treatment. Finally, the need to increase awareness of physicians about fascioliasis is highlighted, mainly in non-human endemic areas.
An Emerging Role of Extracellular Traps in Chronic Rhinosinusitis
Authors: Zhang Siyuan , Wang Zhenlin 
Published: November 2023

Abstract
Purpose of Review
Chronic rhinosinusitis (CRS) is a complicated, heterogeneous disease likely caused by inflammatory and infectious factors. There is clear evidence that innate immune cells, including neutrophils and eosinophils, play a significant role in CRS. Multiple immune cells, including neutrophils and eosinophils, have been shown to release chromatin and granular proteins into the extracellular space in response to triggering extracellular traps (ETs). The formation of ETs remains controversial due to their critical function during pathogen clearance while being associated with harmful inflammatory illnesses. This article summarizes recent research on neutrophil extracellular traps (NETs) and eosinophil extracellular traps (EETs) and their possible significance in the pathophysiology of CRS.

Recent Findings
A novel type of programmed cell death called ETosis, which releases ETs, has been proposed by recent study. Significantly more NETs are presented in nasal polyps, and its granule proteins LL‐37 induce NETs production in CRS with nasal polyps (CRSwNP) patients. Similar to NETs, developed in the tissue of nasal polyps, primarily in subepithelial regions with epithelial barrier defects, and are associated with linked to elevated tissue levels of IL-5 and S. aureus colonization.

Summary
This article provides a comprehensive overview of NETs and EETs, as well as an in-depth understanding of the functions of these ETs in CRS.
Bildung, Bildungserfolg und Schule
Authors: Schmitt Anna , Kleine-Niermann Konstantin , Lange Eva , Vatter Lisa , Ziegler Holger 
Published: November 2023

ZusammenfassungDer Beitrag zeichnet nach, dass sich gerade ambulante Hilfen zur Erziehung als unspezifische Hilfen verstehen lassen. Dabei wird eine breite Reihe von schul-, und bildungsrelevanten Fragen und Problematiken zum Thema. Bildungserfolg bleibt aber weitgehend ausgeklammert bzw. spielt als epiphänomenale Folge eine Rolle. Die sozialrechtliche Gestaltung von Hilfen zur Erziehung als Fürsorgeleistungen erschweren es ‚erfolgreiche‘ Bildung als ein zentrales Thema in ambulanten Hilfen zur Erziehung zu bearbeiten.
Psychological profiles associated with positive and negative risk-taking in adults
Authors: Fryt Joanna , Duell Natasha , Szczygieł Monika 
Published: November 2023

AbstractAlthough risk is often considered in the context of maladaptive behaviors, risks can also be positive, allowing individuals to pursue meaningful goals in a socially accepted way. In this study, we were interested in examining psychological profiles associated with positive and negative risk-taking in adults (N = 275, ages 19–71 years, M = 39.25; SD = 13.73) using latent profile analysis. Specifically, we examined whether distinct profiles of psychological characteristics such as future time perspective, tolerance to ambiguity, and sensitivity to reward and punishment are differentially associated with positive and negative risk-taking. We used the Future Time Perspective Scale (FTPS), the Multiple Stimulus Types Ambiguity Tolerance Scale (MSTAT-II), the Short Version of the Sensitivity to Punishment and Sensitivity to Reward Scale (SPSRQ-SF), the Positive Risk-Taking Scale (PRTS), and the Negative Risk-Taking Scale (NRTS). Findings yielded two profiles: individuals in the first profile, characterized by lower sensitivity to punishment and higher tolerance to ambiguity, future time perspective, and sensitivity to reward, endorsed greater positive and negative risk-taking. Conversely, individuals in the second profile, characterized by heightened sensitivity to punishment and lower tolerance to ambiguity, future time perspective, and sensitivity to reward, endorsed lower positive and negative risk-taking. The study contributes to previous findings by identifying additional psychological characteristics that may be associated with both positive and negative risk-taking in adults.
Leveraging GNSS tropospheric products for machine learning-based land subsidence prediction
Authors: Tasan Melika , Ghorbaninasab Zahrasadat , Haji-Aghajany Saeid , Ghiasvand Alireza 
Published: November 2023

AbstractLand subsidence is a hazardous phenomenon that requires accurate prediction to mitigate losses and prevent casualties. This study explores the utilization of the Long Short-Term Memory (LSTM) method for time series prediction of land subsidence, considering various contributing factors such as groundwater levels, soil type and slope, aquifer characteristics, vegetation coverage, land use, depth to the water table, proximity to exploiting wells, distance from rivers, distance from faults, temperature, and wet tropospheric products. Due to the high spatial variability of wet tropospheric parameters, utilizing numerical weather models for extraction is impractical, especially in regions with a sparse network of synoptic stations. This hinders obtaining accurate prediction results because wet tropospheric products play a significant role in subsidence prediction and cannot be ignored in the subsidence prediction process. In this study, Global Navigation Satellite Systems (GNSS) tropospheric products, including Integrated Water Vapor (IWV) and EvapoTranspiration (ET), are employed as alternatives. Two scenarios were considered: one incorporating GNSS products alongside other parameters, and the other relying solely on the remaining parameters in the absence of GNSS tropospheric products. Ground truth data from Interferometric Synthetic Aperture Radar (InSAR) displacement measurements were used for evaluation and testing. The results demonstrated that the inclusion of GNSS tropospheric products significantly enhanced prediction accuracy, with a Root Mean Square Error (RMSE) value of 3.07 cm/year in the first scenario. In the second scenario, the absence of wet tropospheric information led to subpar predictions, highlighting the crucial role of wet tropospheric data in spatial distribution. However, by utilizing tropospheric products obtained from GNSS observations, reasonably accurate predictions of displacement changes were achieved. This study underscores the importance of tropospheric indices and showcases the potential of the LSTM method in conjunction with GNSS observations for effective land subsidence prediction, enabling improved preventive measures and mitigation strategies in regions lacking synoptic data coverage.
Linear and nonlinear regression analysis of phenol and P-nitrophenol adsorption on a hybrid nanocarbon of ACTF: kinetics, isotherm, and thermodynamic modeling
Authors: Gabr Sahar Saad , Mubarak Mahmoud F. , Keshawy Mohamed , El Sayed Ibrahim El Tantawy , Abdel Moghny Thanaa 
Published: November 2023

AbstractThis study aimed to create activated carbon thin film (ACTF) as a hybrid nanocarbon via a simple and efficient method through a single-step mixing process using thermal functionalization techniques. TEM, BET, BJH, FTIR, XRD, and TGA analyses were used to investigate the prepared ACTF. The results exhibited that ACTF has a porous structure with a high surface area of 318 m2/g and important functional groups, which are considered significant adsorption sites. The adsorption performance of ACTF for phenol and p-nitrophenol (PNP) removal from aqueous solutions using batch adsorption mode was studied. Evaluations were conducted on experimental factors influencing the adsorption process, such as pH, initial phenol and PNP concentrations, adsorbent dose, contact time, and temperature. Under the optimized conditions, the phenol and PNP were removed with a maximum efficiency of 89.98% and 92.5%, respectively. The results of linear and nonlinear isotherms and kinetic models of phenol and PNP showed that both pollutants were well fitted with the Freundlich model (R2 = 0.99, χ2 = 0.13, RMSE = 1.6), (R2 = 0.99, χ2 = 0.42, RMSE = 2.8), and the pseudo-second-order model (R2 = 0.999, χ2 = 0.03, RMSE = 0.31), (R2 = 0.99, χ2 = 0.01, RMSE = 0.24), for phenol and PNP, respectively. According to the calculated thermodynamic results, the adsorption of phenol and p-nitrophenol onto the ACTF surface was a spontaneous and exothermic reaction. The regeneration experiments showed that the spent ACTF could be reused up to the fifth cycle while maintaining noteworthy removal efficiency.