bluuebunny/crossref_metadata_2025_split huggingface dataset:
Genomic context-dependent histone H3K36 methylation by threeDrosophilamethyltransferases and implications for dedicated chromatin readers
Authors: Jayakrishnan Muhunden , Havlová Magdalena , Veverka Václav , Regnard Catherine , Becker Peter B. 
Published: February 2024

AbstractMethylation of histone H3 at lysine 36 (H3K36me3) marks active chromatin. The mark is interpreted by epigenetic readers that assist transcription and safeguard the integrity of the chromatin fiber.The chromodomain protein MSL3 binds H3K36me3 to target X-chromosomal genes in maleDrosophilafor dosage compensation. The PWWP-domain protein JASPer recruits the JIL1 kinase to active chromatin on all chromosomes. Unexpectedly, depletion of K36me3 had variable, locus-specific effects on the interactions of those readers. This observation motivated a systematic and comprehensive study of K36 methylation in a defined cellular model.Contrasting prevailing models, we found that K36me1, K36me2 and K36me3 each represent independent chromatin states. A gene-centric view of the changing K36 methylation landscape upon depletion of the three methyltransferases Set2, NSD and Ash1 revealed local, context-specific methylation signatures. Set2 catalyzes K36me3 predominantly at transcriptionally active euchromatin. NSD places K36me2/3 at defined loci within pericentric heterochromatin and on weakly transcribed euchromatic genes. Ash1 deposits K36me1 at regions with enhancer signatures.The genome-wide mapping of MSL3 and JASPer suggested that they bind K36me2 in addition to K36me3, which was confirmed by direct affinity measurement. This dual specificity attracts the readers to a broader range of chromosomal locations and increases the robustness of their actions.
Cellular coordination underpins rapid reversals in gliding filamentous cyanobacteria and its loss results in plectonemes
Authors: Rosko Jerko , Cremin Kelsey , Locatelli Emanuele , Coates Mary , Duxbury Sarah J. N. , Randall Kieran , Croft Katie , Valeriani Chantal , Polin Marco , Soyer Orkun S. 
Published: February 2024

AbstractCyanobacteria are key contributors to biogeochemical cycles through photosynthesis and carbon fixation. In filamentous, multicellular cyanobacteria these functions can be influenced through gliding motility, which enables filaments to localise in response to light and also form aggregates. Here, we use the aggregate forming speciesFluctiforma draycotensisto study gliding motility dynamics in detail. We find that filaments move in curved and straight trajectories interspersed with re-orientation or reversal of direction. Most reversals take few seconds but some take substantially longer, resulting in a long-tailed distribution of stoppage times. Mean filament speeds range around a micron per second with a relatively uniform distribution against filament length, implying that all or fixed proportion of cells in a filament contribute to movement. We implement a biophysical model that can recapitulate these findings. Model simulations show that for filaments to reverse quickly, cells in a filament must achieve high coordination of the direction of the forces that they generate. To seek experimental support of this prediction, we track individual cells in a filament. This reveals that cells’ translational movement is fully coupled with their rotation along the long-axis of the filament, and that cellular movement remains coordinated throughout a reversal. For some filaments, especially longer ones, however, we also find that cellular coordination can be lost, and filaments can form buckles that can twist around themselves, resulting in plectonemes. The experimental findings and the biophysical model presented here will inform future studies of individual and collective filament movement.Significance StatementCyanobacteria contribute to global oxygen production and carbon capture. Some cyanobacteria exist as multicellular filaments and display gliding motility that allows them to respond to light and to form aggregates, which influences their biological functions. Here, we study the dynamics of gliding motility. We find that filaments’ movement is interspersed with re-orientation or reversal of direction and that mean filament speed is mostly independent of filament length. We implement a biophysical model that predicts these features to relate to cells in a filament having high coordination of the direction of the forces that they generate. We find experimental support for this predicted cellular coordination, but also discover instances of longer filaments loosing coordination, resulting in buckling and entangling with other filaments.
Multi-GeV wakefield acceleration in a plasma-modulated plasma accelerator
Authors: van de Wetering J. J. , Hooker S. M. , Walczak R. 
Published: February 2024

We investigate the accelerator stage of a plasma-modulated plasma accelerator (P-MoPA) [Jakobsson , ] using both the paraxial wave equation and particle-in-cell (PIC) simulations. We show that adjusting the laser and plasma parameters of the modulator stage of a P-MoPA allows the temporal profile of pulses within the pulse train to be controlled, which in turn allows the wake amplitude in the accelerator stage to be as much as 72% larger than that generated by a plasma beat-wave accelerator with the same total drive laser energy. Our analysis shows that Rosenbluth-Liu detuning is unimportant in a P-MoPA if the number of pulses in the train is less than ∼30, and that this detuning is also partially counteracted by increased red-shifting, and hence increased pulse spacing, towards the back of the train. An analysis of transverse mode oscillations of the driving pulse train is found to be in good agreement with 2D (Cartesian) PIC simulations. PIC simulations demonstrating energy gains of ∼1.5GeV (∼2.5GeV) for drive pulse energies of 2.4J (5.0J) are presented. Our results suggest that P-MoPAs driven by few-joule, picosecond pulses, such as those provided by high-repetition-rate thin-disk lasers, could accelerate electron bunches to multi-GeV energies at pulse repetition rates in the kilohertz range.

Published by the American Physical Society
2024
An empirically validated framework for investigating the perception of density
Authors: Patil Madhavi Prashant , Romice Ombretta 
Published: February 2024

Purpose In urban studies, understanding how individuals perceive density is a complex challenge due to the subjective nature of this perception, which is influenced by sociocultural, personal and environmental factors. This study addresses these complexities by proposing a systematic framework for comprehending how people perceive density within urban contexts.Design/methodology/approachThe methodology for developing the framework involved a systematic review of existing literature on the perception of density and related concepts, followed by integrating insights from empirical investigations. The framework designed through this process overcomes the limitations identified in previous research and provides a comprehensive guide for studying perceived density in urban environments.FindingsThe successful application of the framework on case studies in Glasgow and international settings enabled the identification of 20 critical spatial factors (buildings, public realm and urban massing) influencing density perception. The research provided insights into the subjective nature of density perception and the impact that spatial characters of urban form play, demonstrating the framework's effectiveness in understanding the impact of urban form, which is the realm of design and planning professions, on individual experiences.Originality/value The paper's originality lies in its comprehensive synthesis of the existing knowledge on the perception of density, the development of a user-responsive framework adaptable to future research and its application in case studies of different natures to identify recurrent links between urban form and user-specific constructs.
How important is a high-performance work system to improve branch-level performance?
Authors: Riaz Amir , Mahmood Zahid , Qammar Ahmad , Ali Imran 
Published: February 2024

Purpose
This study aims to propose and empirically examine the simultaneous complementary mediating role of bank branch collective human capital and justice climate between implemented high-performance work system (HPWS) and bank branch performance in the banking sector.

Design/methodology/approach
Data were collected at three different intervals of time between March 2022 to July 2022 from a final sample of 323 branch managers and 1,369 employees of commercial banks operating in Pakistan. Partial least square structural equation modeling was used to test the theoretical model proposed by this study.

Findings
Study results revealed that collective human capital and justice climate simultaneously mediate the relationship between implemented HPWS and branch performance.

Research limitations/implications
The study contributes to the strategic HRM theory by proposing the complementary mediating roles of human capital and organizational justice to reap the benefits of implementing HPWS for improving branch-level performance. The managers should focus on developing and exploiting the knowledge, skills and experiences (human capital) of branch employees and improve their collective perceptions of justice to reap the benefits of HPWS for enhancing branch-level performance.

Originality/value
Drawing upon the resource-based view of the firm and organizational justice theory, this novel study examines the simultaneous and complementary mediating effects of collective human capital and justice climate between implemented HPWS and branch performance relationships at the branch-level analysis.
Flying responsibly: effects of perceived corporate social responsibility on attitudes and behaviors of employees in the European aviation industry
Authors: Athanasiadou Chrisalena , Theriou Georgios , Chatzoudes Dimitrios 
Published: February 2024

PurposeThis study aims to examine how corporate social responsibility (CSR) affected the attitudes and behaviors of employees in the European aviation industry amidst the COVID-19 pandemic and to explore any moderating effect of empathetic leadership.Design/methodology/approachBased on the social identity and social exchange theories, a research model was developed and tested against empirical data collected from employees of the European aviation industry, in 2021. Structural equation modeling and regression analyses were used for testing the hypothesized causal relationships.FindingsPerceived CSR is directly related to work engagement and indirectly associated with work engagement and job insecurity via organizational pride. The presence of an empathetic leader does not intensify the effects of perceptions of CSR on organizational pride. Work engagement, in turn, impacts organizational citizenship behavior, while no such effect of job insecurity is supported.Originality/valueThis study provides insight into the underlying mechanisms via which CSR affects employees during a crisis. It, also, has significant implications on human resources management within the industries severely affected by the pandemic.
Restorative justice in safeguarding adults with hate crime and discriminatory abuse: exploring the evidence
Authors: Mason Karl , Dray Rosslyn , Healy Jane C. , Wells Joanna 
Published: February 2024

Purpose
The purpose of this paper is to consider what safeguarding responses to discriminatory abuse and hate crime might learn from existing research on restorative justice and to drive practice development based on available evidence.

Design/methodology/approach
This paper is based on a scoping review of literature using four academic databases and reference harvesting. This comprised a critical appraisal of 30 articles, which were thematically analysed to appreciate the benefits and challenges of restorative justice responses to hate crime and how this might inform safeguarding responses to discriminatory abuse and hate crime.

Findings
The analysis identifies four domains where learning can be drawn. These relate to theory on restorative justice; restorative justice practices; perspectives from lived experience of restorative justice and hate crime; and an appraisal of critiques about restorative justice.

Originality/value
This paper connects the emerging evidence on restorative criminal justice responses to hate crime to the “turn” towards strengths-based practices in adult safeguarding. Although this provides a fertile environment for embedding restorative practices, the authors argue certain precautions are required based on evidence from existing research on hate crime and restorative justice.
The impact of the US stock market on the BRICS and G7: a GVAR approach
Authors: Attílio Luccas Assis , Faria Joao Ricardo , Prado Mauricio 
Published: February 2024

PurposeThe authors investigate the impact of the US stock market on the economies of the BRICS and major industrialized economies (G7).Design/methodology/approachThe authors construct the world economy and the vulnerability between economies using three economic integration variables: bilateral trade, bilateral direct investment and bilateral equity positions. Global vector autoregressive (GVAR) empirical studies usually adopt trade integration to estimate models. The authors complement these studies by using bilateral financial flows.FindingsThe authors summarize the results in four points: (1) financial integration variables increase the effect of the US stock market on the BRICS and G7, (2) the US shock produces similar responses in these groups regarding industrial production, stock markets and confidence but different responses regarding domestic currencies: in the BRICS, the authors detect appreciation of the currencies, while in the G7, the authors find depreciation, (3) G7 stock markets and policy rates are more sensitive to the US shock than the BRICS and (4) the estimates point out to heterogeneities such as the importance of industrial production to the transmission shock in Japan and China, the exchange rate to India, Japan and the UK, the interest rates to the Eurozone and the UK and confidence to Brazil, South Africa and Canada.Research limitations/implicationsThe results reinforce the importance of taking into account different levels of economic development.Originality/valueThe authors construct the world economy and the vulnerability between economies using three economic integration variables: bilateral trade, bilateral direct investment and bilateral equity positions. GVAR empirical studies usually adopt trade integration to estimate models. The authors complement these studies by using bilateral financial flows.
Impact of non thermal techniques on millets
Authors: Kaur Chinkle , Kaur Jasleen 
Published: February 2024

Purpose
Millets are ancient grains, following wheat, that have been a fundamental source of human sustenance. These are nutrient-rich small-seeded grains that have gained prominence and admiration globally due to their super resilience in diverse climates and significant nutritional benefits. As millets are renowned for their nutritional richness, the demand for millet-based products increases. Hence, this paper aims in identifying the growing need for innovative processing techniques that not only preserve their nutritional content but also extend their shelf life.

Design/methodology/approach
In traditional times, heat was the only means of cooking and processing of the foods, but the amount of damage they used to cause to the sensorial and nutritional properties was huge. Millets’ sensitivity toward heat poses a challenge, as their composition is susceptible to disruption during various heat treatments and manufacturing processes. To cater to this drawback while ensuring the prolonged shelf life and nutrient preservation, various innovative approaches such as cold plasma, infrared technology and high hydrostatic pressure (HPP) processing are being widely used. These new methodologies aim on inactivating the microorganisms that have been developed within the food, providing the unprocessed, raw and natural form of nutrients in food products.

Findings
Among these approaches, nonthermal technology has emerged as a key player that prioritizes brief treatment periods and avoids the use of high temperatures. Nonthermal techniques (cold plasma, infrared radiation, HPP processing, ultra-sonication and pulsed electric field) facilitate the conservation of millet’s nutritional integrity by minimizing the degradation of heat-sensitive nutrients like vitamins and antioxidants. Acknowledging the potential applications and processing efficiency of nonthermal techniques, the food industry has embarked on substantial investments in this technology. The present study provides an in-depth exploration of the array of nonthermal technologies used in the food industry and their effects on the physical and chemical composition of diverse millet varieties.

Originality/value
Nonthermal techniques, compared to conventional thermal methods, are environmentally sound processes that contribute to energy conservation. However, these conveniences are accompanied by challenges, and this review not only elucidates these challenges but also focuses on the future implications of nonthermal techniques.
How grumpy cat helped students learn management concepts
Authors: Julien Mark , Stratton Micheal , Schmidt Gordon B. , Clayton Russell 
Published: February 2024

Purpose
Management educators often seek out innovative ways to introduce theories and concepts in such a way that students are more engaged and connected with the course material. A meme is an image juxtaposed with short text that elicits emotional responses from its readers and is now a staple in social media. Examples include: grumpy cat, success kid and distracted boyfriend. The authors have successfully used memes both online and in-person as a teaching tool. This paper aims to describe how the authors have used memes and some of the best practices and lessons learned from this experience.

Design/methodology/approach
Students in a training and development undergraduate course and an organizational behavior MBA course were tasked with creating and presenting memes that reflected the subject matter in their respective courses.

Findings
Their fellow students were successful in identifying the course theory or concept when these student presenters presented their memes in class. This suggests that this type of activity is helpful for students to apply a key course concept or theory in a way that was fun and interactive. Follow-up feedback from the students indicated that they enjoyed this type of activity and felt that it aided in their retention of course material.

Originality/value
While memes are quite popular in social media, there is a paucity of academic articles on the application of memes for teaching management concepts. This article guides instructors on how the authors have used memes in the classroom and offers some suggestions for doing a debrief afterward.
Perspectives on gender diversity in the Australian valuation industry: experiences and insights from management and senior leadership
Authors: Callanan Judith , Leshinsky Rebecca , Halvitigala Dulani , Amponsah Effah 
Published: February 2024

PurposeThis paper examines gender diversity in the Australian valuation industry from the perspective of valuers in senior management and leadership roles and discusses gender diversity policies and practices in their organisations. Then, it explores the initiatives that can be implemented to improve gender diversity in the Australian valuation industry.Design/methodology/approachA focus group discussion was conducted with valuers in senior management and leadership roles from selected large valuation firms and government valuation agencies in Melbourne, Australia. Data collected through the focus group discussion was combined with secondary data sourced from journals, online articles and archival materials.FindingsThe findings reveal that whilst gender diversity in the Australian valuation industry has improved over the years, females remain underrepresented. Nonetheless, whilst some valuation companies have recognised the need to address the underrepresentation of women and introduced specific gender-focussed human resource policies and practices, these initiatives are not streamlined and implemented across the industry.Research limitations/implicationsThe study highlights the need for closer collaboration between key stakeholders such as universities, professional associations, valuation companies and government agencies in devising strategies to attract female talents into the valuation industry.Originality/valueThe paper is the first empirical study to assess gender diversity in the Australian valuation industry from the perspective of valuers in management and leadership roles. The proposed policies can inform future initiatives to improve gender diversity in the valuation industry.
Research on Automotive Seat Heating Strategy Based on Objective Thermal Comfort Evaluation
Authors: Wang Shuang , Ren Siyuan 
Published: February 2024

Abstract
Seat heating is an essential means to improve cabin occupant thermal comfort. How to set a reasonable seat heating strategy is very important to improve occupant thermal comfort and reduce vehicle energy consumption. Based on objective thermal comfort evaluation criteria, this paper analyzes three strategies: fixed heating power, fixed seat surface temperature, and intermittent seat heating. It explores the occupant thermal comfort characteristics under different strategies. It is found that the optimum heating power or optimum seat surface temperature to maintain occupant thermal comfort varies with the initial seat temperature. Compared with the two strategies of fixed heating power and fixed seat surface temperature, the intermittent seat heating proposed in this paper can make the human body reach the optimal state of comfort in a shorter period, and the power consumption is less as the seat heating is opened for a longer time. This intermittent seat heating strategy not only adapts to different low-temperature environments outside but also provides sufficient safety guarantees while improving human thermal comfort. It can provide some references for the design of car seat heating and research on passenger cabin thermal comfort.