bluuebunny/crossref_metadata_2025_split huggingface dataset:
Cost‐effectiveness analysis of CYP2C19 genotype‐guided antiplatelet therapy for patients with acute minor ischemic stroke and high‐risk transient ischemic attack in China
Authors: Zhang Zhuolin , Bao Yuwen , Gu Yajie , Zhang Mengdie , Li Xin 
Published: October 2023

AimsThe study aimed to estimate the cost‐effectiveness of CYP2C19 genotype‐guided antiplatelet therapy using cilostazol and ticagrelor as an alternative to clopidogrel, compared to conventional antiplatelet therapy with clopidogrel and aspirin.MethodsA 90‐day decision tree and 30‐year Markov model were employed to assess the costs and quality‐adjusted life years (QALYs) of personalized antiplatelet therapy for patients with minor ischemic stroke and high‐risk transient ischemic attack, compared to conventional antiplatelet therapy in the Chinese healthcare system. The primary outcome was the incremental cost‐effectiveness ratio (ICER). The data sources included clinical trials, published literature, official documents and local prices. One‐way sensitivity analysis and probabilistic sensitivity analysis were performed to confirm the robustness of the findings.ResultsThe base‐case analysis indicated that the CYP2C19 genotype‐guided antiplatelet strategy was cost‐effective, and cilostazol group and ticagrelor group yielded an ICER of 3327.40 US dollars (USD)/QALY and 3426.92 USD/QALY, respectively, which were less than threshold. The one‐way sensitivity analysis showed the results were robust, where the most sensitive parameter was the disability distribution in the modified Rankin scale 3‐5. The probabilistic analysis showed that the CYP2C19 genotype‐guided antiplatelet therapy with either cilostazol or ticagrelor was 100% cost‐effective under the willingness‐to‐pay threshold.ConclusionsCYP2C19 genotype‐guided antiplatelet therapy using cilostazol and ticagrelor as an alternative to clopidogrel appeared to be more cost‐effective than conventional antiplatelet therapy for acute minor ischemic stroke and high‐risk transient ischemic attack patients over 30 years in China.
Quality or breadth? Environmental information disclosure, corporate financial performance and the role of analysts
Authors: Yao Nengzhi , Ouyang Zhe , Guo Qiaozhe , Gong Xiuyuan 
Published: October 2023

AbstractEnvironmental information disclosure (EID) is an important part of environmental management practices, and it has become a reference for stakeholders to evaluate firms. To obtain support from stakeholders, such as analysts, firms can disclose information that indicates how good they perform in environmental protection, which we referred to as EID quality, and/or that covers multiple aspects of environmental protection, which we referred to as EID breadth. Given the importance of EID practices, this study examines whether and how these two dimensions of EID affect corporate financial performance (CFP). Analyzing a sample of publicly listed manufacturing firms from 2009 to 2019 in China, we find that EID breadth has a positive relationship with CFP, while EID quality has a negative impact on CFP after controlling for EID breadth. In addition, we find that the positive impact of EID breadth on CFP is achieved by enhancing analyst coverage, while the effect of EID quality on CFP is achieved by analyst recommendation. Our work contributes to the literature on EID by uncovering different mechanisms about how EID quality and EID breadth affect CFP and offers important implications regarding the management and governance of EID practices.
Supporting people to live well: A multimethod study of Shared Lives (adult placement)
Authors: Brookes Nadia , Palmer Sinead , Collins Grace , Callaghan Lisa 
Published: October 2023

AbstractBackgroundShared Lives (adult placement) is a model of community‐based support where an adult who needs support and/or accommodation moves into or regularly visits the home of an approved Shared Lives carer. It is an established but small‐scale service used mainly by adults with learning disabilities. However, little research has been conducted about whether and in what ways this model can support people to live well.MethodThis article presents findings from outcome measures focused on well‐being for a sample of 39 people supported by Shared Lives in England. Fifteen semistructured interviews were also conducted by peer/coresearchers to supplement the quantitative data. Data collection took place between June 2017 and September 2018.FindingsFindings indicated that people using Shared Lives generally had good outcomes across all of the measures. All of those interviewed identified areas of their life where Shared Lives had made a positive difference, particularly with relationships and activities.ConclusionsLimitations to the research mean that more work is needed to fully understand the role Shared Lives plays in supporting people to live well and in comparison to other forms of community support.
Early gonadogenesis inColumba livia(birds: Columbiformes): Migration, colonization, and differentiation of germ cells
Authors: Olea Gabriela Beatriz , Aguirre María Victoria , Lombardo Daniel Marcelo 
Published: October 2023

AbstractIn birds, primordial germ cells (PGCs) use the bloodstream to travel to a specific region, where the cells undergo extravasation followed by intrastromal migration to the gonadal crest for further colonization. Currently, DDX4, SSEA1, and Oct4 are used to identify germ cells. Other germline cell‐associated molecules are N‐cadherin, GnRHR, and 3β hydroxysteroid dehydrogenase (3βHSD), which have been used in mice and birds during gonadal development; however, its role in early gonadogenesis in birds is poorly described. This study aimed to evaluate the differential immunodetection of N‐cadherin binding molecule, Oct4 pluripotency protein, GnRHR receptor, and 3βHSD enzyme inColumba liviaembryos during migration colonization of PGCs in the gonadal crest and early gonadogenesis. These markers were revealed by immunohistochemistry in histological preparations ofC. liviacorresponding to stages (S)15 to S40. Immunodetection of N‐cadherin, Oct4, GnRHR, and 3βHSD in the germ line ofC. liviaallowed the identification of PGCs in the yolk sac membrane at the level of the splanchnic mesoderm during migration to the genital crest and its colonization. In the same way, it was possible to characterize and localize PGCs during early gonadogenesis. This study inC. liviademonstrates that Oct4, N‐cadherin, GNRHR, and 3βHSD are immunodetected in PGCs and could be used as potential germline cell markers during cell migration out of blood vessels, colonization in the genital crest, and early gonadogenesis. Furthermore, this study could be used as a novel general model to understand the early gonadogenesis in altricial species.
Using artificial intelligence‐based technologies to detect clinically relevant changes of gross motor function in children with cerebral palsy
Authors: Schafmeyer Leonie , Losch Heike , Bossier Christiane , Lanz Isabel , Wunram Heidrun Lioba , Schoenau Eckhard , Duran Ibrahim 
Published: October 2023

AbstractAimTo compare the 66‐item Gross Motor Function Measure (GMFM‐66) with the reduced version of the GMFM‐66 (rGMFM‐66) with respect to the detection of clinically relevant changes in gross motor function in children with cerebral palsy (CP).MethodThe study was a retrospective single centre analysis of children with CP who participated in a rehabilitation programme. Overall, 1352 pairs of GMFM‐66 and rGMFM66 measurements with a time interval of 5 to 7 months were available. To measure clinically relevant changes in gross motor function, the individual effect size (iES) was calculated.ResultsThe study population consisted of 1352 children (539 females), mean age 6 years 4 months (SD 2 years 4 months). The iES based on the GMFM‐66 and the rGMFM‐66 showed a significant correlation (r = 0.84, p < 0.001). The analysis of the area under the receiver operating characteristic curve showed an excellent agreement for clinically relevant gross motor improvement (Cohen’s d ≥ 0.5; area under the curve = 0.90 [95% confidence interval 0.88–0.92]) or deterioration (Cohen’s d ≤ −0.5; area under the curve = 0.95 [95% confidence interval 0.92–0.97]).InterpretationPerforming the rGMFM‐66 saves time compared to the full GMFM‐66. The rGMFM‐66 showed good agreement with the GMFM‐66 with respect to the detection of clinically relevant changes in gross motor function in children with CP, so its use in everyday clinical practice seems justifiable.What this paper adds

The reduced version of the 66‐item Gross Motor Function Measure (rGMFM‐66) detects clinically relevant changes in gross motor function in children with cerebral palsy.
The rGMFM‐66 correlates highly with the full GMFM‐66.
The rGMFM‐66 can be used in clinical practice when the time schedule is limited.
The relationship between glycated haemoglobin and blood glucose‐lowering treatment trajectories in type 2 diabetes: The Fremantle Diabetes Study Phase II
Authors: Davis Timothy M. E. , Davis Wendy 
Published: October 2023

AbstractAimsTo examine the relationships between glycaemia and treatment complexity over 6 years in well‐characterized community‐based people with type 2 diabetes.Materials and MethodsFremantle Diabetes Study Phase II participants who had type 2 diabetes with glycated haemoglobin (HbA1c) and blood glucose‐lowering therapy (BGLT) data over 6 years were included. Group‐based multi‐trajectory modelling identified combined HbA1c/BGLT trajectory subgroups for diabetes durations of ≤1.0 year (Group 1; n = 160), >1.0 to 10.0 years (Group 2; n = 382;) and >10.0 years (Group 3; n = 357). Multinomial regression was used to identify baseline associates of subgroup membership.ResultsThe optimum numbers of trajectory subgroups were three in Group 1 (low, medium, high) and four in Groups 2 and 3 (low, low/high medium, high). Each low trajectory subgroup maintained a mean HbA1c concentration of <53 mmol/mol (<7.0%) on lifestyle measures, or monotherapy (Group 3). All five medium subgroups had stable HbA1c trajectories at <58 mmol/mol (<7.5%) but required increasing oral BGLT, or insulin (Group 3, high medium). The Group 1 high subgroup showed a falling then increasing HbA1c with steady progression to insulin. The high subgroups in Groups 2 and 3 showed stable HbA1c profiles at means of approximately 64 mmol/mol (8.0%) and 86 mmol/L (10.0%), respectively, on insulin. Non‐Anglo Celt ethnicity, central obesity and hypertriglyceridaemia were strongly associated with Group 1 high subgroup membership. Younger age at diagnosis and central obesity were independent associates of the most adverse HbA1c trajectories in Groups 2 and 3.ConclusionsThese data demonstrate diabetes duration‐dependent heterogeneity in glycaemic and treatment profiles and related clinical and laboratory variables, which have implications for management.
A generic decision support framework for identification of societal impact themes and its measurement in a B‐school
Authors: Paul Jomon A. , Gala Prachi 
Published: October 2023

AbstractBusiness schools play an important role in making positive contributions to society. Thus, the Association to Advance Collegiate Schools of Business (AACSB) has placed societal impact as an expectation of all accredited schools. This article proposes an integrated multisource and multimethod approach to measure the societal impact of a business school. Using data from various sources (primary data collection via faculty survey and secondary data via faculty annual review documents) we were able to identify societal impact themes that aligned with college activities in teaching, research, and community engagement. AACSB's outlook on societal impact and the United Nations’ sustainable development goals (SDGs) provided the guiding framework. We performed content analyses using DICTION software on the data to algorithmically discover the themes characterizing societal impact. To further support our data collection efforts, faculty listening sessions and discussions with unit heads were also conducted. Decent Work and Economic Growth; and Industry, Innovation, and Infrastructure emerged as the top two themes. Using word clouds, multiple subthemes emerged from these two overarching themes. To conclude, we discuss an approach to operationalizing these themes by quantifying societal impact in a business school.
Breast cancer resistance protein polymorphism ABCG2 c.421C>A (rs2231142) moderates the effect of valproate on lamotrigine trough concentrations in adults with epilepsy
Authors: Šušak Sporiš Ivana , Božina Nada , Klarica Domjanović Iva , Sporiš Davor , Bašić Silvio , Bašić Ivana , Lovrić Mila , Ganoci Lana , Trkulja Vladimir 
Published: October 2023

AbstractBackgroundValproate inhibits clearance of lamotrigine and greatly increases its concentrations. We assessed whether this effect was moderated by a polymorphism (ABCG2 c.421C>A) of the breast cancer resistance protein.MethodsIn two consecutive independent studies in adults with epilepsy on lamotrigine monotherapy or cotreated with valproate: (i) Exposure to valproate was considered treatment, (ii) dose‐adjusted lamotrigine troughs at steady state were the outcome, and (iii) ABCG2 c.421C>A genotype (wild‐type [wt] homozygosity or variant carriage) was the tested moderator. We used entropy balancing (primary analysis) and exact/optimal full matching (secondary analysis) to control for confounding, including polymorphisms (and linked polymorphisms) suggested to affect exposure to lamotrigine (UGT1A4*3 c.142T>G, rs2011425; UGT2B7–161C>T, rs7668258; ABCB1 1236C>T, rs1128503) to generate frequentist and Bayesian estimates of valproate effects (geometric means ratios [GMR]).ResultsThe two studies yielded consistent results (replicated); hence, we analyzed combined data (total N = 471, 140 treated, 331 controls, 378 ABCG2 c.421C>A wt subjects, 93 variant carriers). Primary analysis: in variant carriers, valproate effect (GMR) on lamotrigine (treated, n = 21 vs. controls, n = 72) was around 60% higher than in wt subjects (treated, n = 119 vs. controls, n = 259)—ratio of GMRs 1.61 (95%CI 1.23–2.11) (frequentist) and 1.63 (95%CrI 1.26–2.10) (Bayes). Similar differences in valproate effects between variant carriers and wt subjects were found in the secondary analysis (valproate troughs up to 364 μmol/L vs. no valproate; or valproate ≥364 μmol/L vs. no valproate). Susceptibility of the estimates to unmeasured confounding was low.ConclusionData suggest that polymorphism rs2231142 moderates the effect of valproate on exposure to lamotrigine.
Effect of vacuum impregnation with melatonin, γ‐aminobutyric acid, and oxalic acid on chilling injury and quality of carambola
Authors: Mohd Yusof Farah Anum , Azman Ezzat Mohamad , Mohd Adzahan Noranizan , Yusof Noor Liyana 
Published: October 2023

SummaryCarambola is a nutrient‐rich tropical fruit that ripens and spoils rapidly at ambient temperature, making low‐temperature storage a preferable method to address this problem. Unfortunately, carambola suffered a chilling injury when stored at low temperatures. Carambola was vacuum impregnated with melatonin (MT), γ‐aminobutyric acid (GABA), and oxalic acid (OA) to mitigate chilling injury and improve its quality during cold storage. Carambola fruits were stored at 4 °C for 28 days and analysed every 7 days. Weight loss, firmness, physicochemical properties, phenolic content, flavonoid content, and proline content were assessed. MT‐treated carambola has the highest firmness, 146.31 g and lowest weight loss, 1.53% in comparison to others by the end of the storage period. Visual observations showed that MT‐treated carambola ripened evenly, without any chilling injury symptoms and decay was also delayed, whereas OA‐ and GABA‐treated carambola started to decay on day 28. Instead of degrading, phenolics and flavonoids were retained with 6.10% and 12.67% increase when compared to the initial level. GABA‐treated carambola can also retain its phenolic and flavonoid content; meanwhile, OA‐treated carambola can only retain its phenolic content. Therefore, MT can be applied to mitigate chilling injury and maintain the quality of carambola.
Is seeing always good? The influence of organic food packaging transparency on consumers' purchase intentions
Authors: Liang Shichang , Yuan Xueying , Han Xiaoyan , Han Chun , Liu Zhen , Liang Meiting 
Published: October 2023

SummaryOrganic food enjoys widespread popularity; however, there are numerous factors influencing our purchasing decisions in this regard. Among these factors, packaging stands as a significantly salient determinant. While numerous studies have examined various aspects of organic food packaging, such as design, materials, and size, the impact of packaging transparency has received relatively less attention. Consequently, this research explores the Influence of transparency in organic food packaging on consumers' purchase intentions. The findings from two experiments illustrate that transparency in organic food packaging significantly impacts consumers' purchase intentions. Specifically, organic food with transparent packaging (vs. opaque) increases consumers' purchase intentions, with green perceived value (GPV) playing an intermediary role (Experiment 1). Additionally, consumers' self‐construal, which relates to their sense of individuality or interconnectedness with others, moderates the Influence of packaging transparency on their purchase intentions; for individuals with an independent self‐construal, organic food with transparent packaging increases their purchasing intentions. On the other hand, individuals with an interdependent self‐construal show higher purchase intentions for organic food with opaque packaging than transparent packaging (Experiment 2). These findings shed light on the psychological mechanisms and contextual factors determining how organic food packaging transparency affects consumers' purchasing intentions. They also offer practical implications for companies in terms of designing packaging transparency and other aspects of organic food packaging.
Update on the management of first episode primary spontaneous pneumothorax in an Australian hospital network
Authors: Chew Christopher , Bartlett James , Kelly Anne‐Maree 
Published: October 2023

AbstractInternational guidelines and recent research favour a less interventional approach to primary spontaneous pneumothorax (PSP). A retrospective clinical audit of 68 first‐episode PSP was undertaken at a major tertiary teaching hospital network in Melbourne, Australia, found that most patients presenting with a moderate to large pneumothorax received initial intercostal catheter insertion (56%), though many (81%) would have met criteria for consideration of conservative management. The results suggest continued deviation from clinical guidelines in the management of PSP.
Suitability of the stress severity index combined with remote‐sensing data as a tool to evaluate drought resistance traits in potato
Authors: Hoelle Julia , Asch Folkard , Khan Awais , Bonierbale Merideth 
Published: October 2023

AbstractPotato is a drought susceptible crop and even short drought spells reduce tuber yields notably. In an earlier study we developed a stress severity index (SSI) based on the development stage of a genotype at the onset of drought and the soil water deficit based on soil water tension. Here, we test the suitability of the SSI combined with remotely sensed data as a screening tool to select drought‐tolerant potato genotypes. Normalized difference vegetation index (NDVI) and the photochemical reflectance index (PRI) were obtained from reflectance measurements and thermography. Temperature data from the thermography allow using the difference between leaf and air temperature (∆T) to estimate the transpirational cooling of the leaves. Via cluster analysis including SSI, tuber yield reduction under drought, NDVI, PRI and thermography, three groups were distinguished: 1. SSI < 1000 with fast decreasing NDVI, PRI and ∆T, 2. SSI 1000–2000 with almost constant NDVI and ∆T and 3. SSI > 2000 described by small changes of NDVI, PRI and temperature deficit. For SSI < 1000, ∆T, PRI and NDVI showed to be good indicators of genotypic performance under drought. Potential strategies for drought resistance in potato detectable through remote sensing are discussed.
Influence of hypertension and global or abdominal obesity on left ventricular hypertrophy: A cross‐sectional study
Authors: Zhang Xueyao , Li Guangxiao , Zhang Dongyuan , Sun Yingxian 
Published: October 2023

AbstractAlthough hypertension and obesity are both risk factors for left ventricular hypertrophy (LVH), the extent of their impact on LVH in the general population is still unclear, and the predictive value of obesity indicators for LVH remains to be elucidated. In this study, obesity‐related indicators, including waist circumference (WC), waist‐height ratio (WHTR), and waist‐hip ratio (WHR), were used to define abdominal obesity (AO), whereas body mass index (BMI) was used to measure general obesity (GO). The effects of hypertension and obesity on LVH were estimated using logistic regression analysis, as was the relative risk of LVH based on the presence of obesity, hypertension, or both. Subgroup analyses were performed based on sex and age. Of the 9134 participants (≥35 years old), 915 (10.0%) developed LVH. After adjusting for covariates, the odds ratios (95% confidence intervals) for LVH were 3.94 (3.27–4.75) in patients with hypertension, 1.90 (1.60–2.26) in those with GO, and 1.45 (1.25–1.69), 1.69 (1.43–2.00), and 1.54 (1.33–4.75) in individuals with AO defined based on WC, WHTR, and WHR, respectively. Analysis by sex showed similar values in women, but AO based on WC and WHR were not significantly associated with LVH in men. Further, after adjusting for potential confounding factors, concomitant hypertension and obesity had an increased risk of developing LVH in all age ranges, particularly in patients aged 35–45 years (risk increased 14.14‐fold, 10.84‐fold, 7.97‐fold, and 9.95‐fold for BMI‐based GO and WC‐, WHTR‐, and WHR‐based AO, respectively), and in both men and women but particularly in men (risk increased 7.71‐fold, 4.67‐fold, 5.83‐fold, and 5.58‐fold, respectively). In summary, all obesity indicators (BMI, WC, WHTR, and WHR) had predictive value for LVH in women; however, only BMI and WHTR should be considered for men. Furthermore, monitoring for the occurrence and progression of LVH is imperative for rural Chinese patients with concomitant hypertension and obesity, especially men and those aged 35–45 years.