bluuebunny/crossref_metadata_2025_split huggingface dataset:
Evaluation of some biomarkers of osteoporosis in women with breast cancer in Al-Najaf Governorate
Authors: AL-Thabhawee Sarah Mohammed Hussein 
Published: January 2024

Introduction: Osteoporosis is a systemic disease that affects the mineral density of bones and their structure, which leads to an increase in the softness of the bones. One in three women after the age of fifty worldwide is affected. Both breast cancer and osteoporosis are common diseases in women. Breast cancer is the most common type of cancer in women, with one in eight women developing breast cancer in their lifetime.Aim of the study Evaluation of some biomarkers of osteoporosis in women with breast cancer represented by cathepsin K, parathyroid hormone, calcium and vitamin D.
methods: The current study was conducted at the National Cancer Center in Al-Najaf province for the period from 8/15/2022 to 1/20/2023. The study included 60 women with breast cancer and 30 healthy women free of diseases, and it was considered a control group. The ages of patients and healthy people ranged between (30-68) years old, vitamin D, calcium, parathyroid hormone, and cathepsin K were evaluated.
Results: For the indicators of vitamin D and parathyroid hormone (PTH), the results of the statistical analysis did not record any significant difference (p>0.05) between the two groups under study. The results of the statistical analysis showed a significant increase (p<0.0001) in the levels of calcium (Ca) and cathepsin K in infected women compared with healthy women. Likelihood (p < 0.005) and calcium with a probability level (p < 0.0001).
Conclusion
Depending on the results reached through the current study, we conclude that there is a high rate of osteoporosis in women with breast cancer. prevalent. Also, an increase in the level of calcium in women with breast cancer, with no difference in parathyroid hormone, which is the most important biomarker for breast cancer diagnosis. An increase in the level of cathepsin K and its negative effect on the level of calcium in women with breast cancer.
Determination of Some Heavy Metals in Tissues of Binni Mesopotamichthys sharpeyi and Water in Al-Dalmaj Marsh/Iraq
Authors: Al-Obeidi Laith , Abbas Al-hamadawi Hussein 
Published: January 2024

The study was conducted in Al-Dalmaj marsh, considered one of the most important wetlands at the national and regional level and represents the most critical environment to form a good stock of Binni Mesopotamichthys sharpeyi in Iraq. The study assessed heavy metals in water and M. sharpeyi by detecting accumulation of (Nickel, Cadmium and Lead) in the tissues of gills, liver, and small intestines during the summer and winter seasons 2022-2023.
The study results showed a high concentration of heavy metals in the water during summer compared to winter. Nickel levels ranged (0.19 ±0.627, 0.20 ±0.531) in water for both stations. The highest concentration was (1.339 mg/L) in suspended phase during summer, and ND in dissolved phase in winter, while Cadmium rates were (0.25±0.948, 0.17±0.478) in both stations respectively, the highest concentration was (1.827 mg/L) in suspended phase of station 1 during summer. Both stations ' lead rates were (0.39±1.455, 0.09±1.117). (3.176 mg/L) was the highest concentration in the suspended phase of station 1 during summer, while (0.121 mg/L) was the lowest in the suspended phase in winter.
The results showed a sequence of concentrations of heavy metals in M. sharpeyi organs: Gills > Liver ≥ Small Intestines. The highest concentration rate of Nickel (4.109 & 3.692 mg/g) was recorded in small intestines and liver, respectively, during winter, the lowest rate (3.057 mg/g) was recorded in the gills during summer, the total of sedimentation rate of Ni in the liver and intestines was (3.726 mg/g), whereas (3.114 mg/g) in gills. Cadmium recorded an equal value of (0.957 mg/g) representing the highest percentage in the small intestines for both seasons. The highest concentrations (0.906 mg/g) in liver during summer. The total sedimentation rate of Cd in liver and small intestines was (0.852 mg/g), while (0.738 mg/g) was in gills. Lead recorded a high significant rate reaching to (8.501 mg/g) in gills during summer, followed by (6.115 mg/g) and (5.891 mg/g) in the liver and small intestines, respectively. Generally, lead reached the highest value for all elements assessed in fish at (8.501 mg/g) in the gills during summer, while (5.027 mg/g) was the highest rate in the liver during winter, and (3.709 mg/g) was the lowest rate in small intestines during winter. The total sedimentation rate of Pb in liver and small intestines was (5.185 mg/g), and (6.41 mg/g) was in the gills. Cadmium was recorded above the permissible (0.05 mg/g) limit by FAO [25] in the small intestine and liver, whereas lead exceeded the allowable limits (5 mg/g) by FAO/WHO [26]. Accordingly, the intake of these organs is unsafe for humans, and the registration of these high values poses a risk to the survival of this species as it can cause the death of fish in their environment under certain conditions.
Assessing the Efficacy of Dextran and Dextransucrase in Modulating MCF-7 Breast Cancer Cell Activity
Authors: Yasameen Hasan Ali  , Nosaif Sahera , Husain Hamza Asraa 
Published: January 2024

Abstract
Tumor development is a complex process involving abnormal cell proliferation within an organism. This study aims to understand tumors, their categorization, formation methods, and effects on human health. Tumor growth is influenced by genetic, environmental, and lifestyle factors. Dextran, a glucose-based polysaccharide, has been used in medical applications for blood plasma substitutes and antithrombotic agents. Researchers are interested in its potential therapeutic applications due to its biocompatibility and unique properties. Dextransucrase, a glucosyltransferase, plays a vital role in synthesizing glucan polymers. Advancements in cancer research reveal the nuanced roles of biopolymers like dextran in tumor biology, drug delivery, and cancer therapy.
In this study MCF-7 cell line maintained in MEM, reseeded twice a week, incubated at 37°C. The MTT cell viability assay was conducted on 96-well plates to assess cytotoxic effects. Cell lines were seeded, treated with the tested compound, and measured after 72 hours. After solubilization, absorbency was determined using a microplate reader at 492 nm.
The results showed A decrease in cell viability was observed with decreasing Dextran concentration, with a negative correlation between concentration and cell viability. A P-value of 0.001 indicates statistically significant effects on MCF-7 cell cytotoxicity, rejecting the null hypothesis that Dextran has no effect. Dextransucrase exhibited a dose-dependent cytotoxicity effect on MCF-7 cells, with a significant effect at the highest concentration (1000) and a negative correlation at the lowest concentration (31.25). The P-value of 0.001 was below the 0.05 threshold, rejecting the null hypothesis. According to the results of cell viability, the highest concentration (1000) had the lowest viability, while the lowest concentration (31.25) had the highest. The data supports the cytotoxic potential of Dextransucrase in a dose-dependent manner.
Pelibatan Pekerja Migran Indonesia (PMI) dalam Kejahatan Terorisme
Authors: Bimantoro Tegar 
Published: January 2024

Terorisme merupakan bentuk tindak kejahatan yang masuk ke dalam extraordinary crime. Sering kali Pekerja Migran terlibat dalam Tindakan terorisme melalui penyebaran paham Radikal yang berkembang. Jurnal penelitian ini bertujuan untuk memberi pengetahuan kepada masyarakat tentang bagaimana proses pelibatan pekerja migran Indonesia hingga menjadi anggota kelompok terorisme, dan menjadi acuan untuk pembuatan kebijakan penanganan terorisme. Jurnal penelitian ini menggunakan metode deskriptif kualitatif. Selanjutnya teori yang digunakan peneliti dalam menjawab tujuan dan permasalahan penelitian yaitu menggunakan teori Golose terkait 9 aktivitas terorisme dan Sutherland terkait teori Differential Association Adapun hasil dari penelitian ini adalah para pekerja migran yang terlibat dalam tindakan terorisme merupakan mereka yang memiliki latar belakang ekonomi yang kurang baik, selanjutnya kondisi diri yang sudah mulai jenuh akan kehidupan dunia, dan aktivitas sehari-hari mereka sebagai pengguna sosial media membuat mereka salah menentukan pilihan. Sosial media dan lingkungan sosial para pelaku terorisme merupakan temuan yang sangat penting dalam penelitian ini bagi para pelaku tindak terorisme yang terpapar paham radikalisme.
Uji Aktivitas Antibakteri Fraksi Etanol Daun Kelor (Moringa oleifera L.) Terhadap Staphylococcus aureus dan Staphylococcus epidermidis
Authors: Dewi Asiska Permata , Darmadi Darmadi , Yesti Yulia 
Published: January 2024

Tanaman kelor (Moringa oliefera L.) merupakan tanaman perdu yang memiliki beberapa kandungan senyawa kimia diantaranya flavonoid, saponin sitokinin, asam-caffeolylquinat dan mengandung asam lemak tak jenuh seperti linoleat (omega 6) dan alfalinolenat (omega 3). Tujuan dari penelitian ini adalah untuk mengetahui kandungan senyawa kimia yang terdapat dalam fraksi etanol daun kelor, serta menguji aktivitas antibakterinya terhadap Staphylococcus aureus dan Staphylococcus epidermidis. Skrining fitokimia dilakukan melalui reaksi warna dengan menggunakan suatu pereaksi tertentu, selanjutnya uji aktivitas antibakteri dilakukan dengan metode difusi cakram dengan konsentrasi fraksi etanol sebesar 15%, 30%, 45% dan 60%. Hasil penelitian menunjukkan senyawa yang terdapat dalam fraksi etanol daun kelor adalah alkaloid, flavonoid, saponin dan tannin. Diameter zona hambat terhadap bakteri S. aureus berada pada rentang 7,43 mm – 10,16 mm, sedangkan terhadap bakteri S. epidermidis berada pada rentang 7,43 mm – 10,48 mm. dapat disimpulkan bahwa fraksi etanol daun kelor memiliki aktivitas antibakteri terhadap bakteri S. aureus dan S. epidermidis.
Utilization of tannin extract from spent coffee ground (SCG) as a green corrosion inhibitor on ferrous metals in acidic and alkaline media
Authors: Sheilatina Sheilatina , Julinawati Julinawati , Shara Fonna Shara Fonna , Fathurrahmi Fathurrahmi 
Published: January 2024

The inhibitory effect of spent coffee grounds (SCG) tannin extract as a corrosion inhibitor on ferrous metal in acid and alkaline media has been carried out. The results of evaluation the corrosion rate (CR) and inhibition efficiency (IE) in this study used the weight loss method. The Internasional Standard (SI) unit for calculating the corrosion rate was mm/year (mmpy). The results of the characterization of SCG tannin extract using Fourier Transform Infrared Spectroscopy (FTIR) showed that the functional groups were O-H, aliphatic C-H, C=O ester, aromatic C=C, C-O-H, and C-O-C ether which indicated the presence of tannin compounds in SCG. The results of the research showed that the maximum concentration of SCG tannin extract in inhibiting corrosion in acidic medium was 1000 ppm with an average CR of 2.2520 mmpy and an IE of 29.23%, while in alkaline medium it was 1000 ppm with an average CR 0.0592 mmpy and IE 50.93% for 5 days of soaking time, respectively. The surface morphology of the corroded ferrous metals was monitored with a USB digital microscope at 1000x magnification.
O MÉTODO CANGURÚ COMO UMA ABORDAGEM MULTIDISCIPLINAR NO CUIDADO DE NEONATOS PREMATUROS
Authors: Nascimento Thiago Ruam , Dumont Fani Elesbão , Costa Daniela Guimarães Alves da , Souza Rayanne Soledade , Pacheco Lívia Delôgo , Nascimento Sandra Kaline Soares , Queiroz Maryonelia Gonçalves , Rosa Victor Hugo Júlio da , Alves Diego Pereira , Melo Carlos Francisco de , Santos Thyanna lima dos , Soares Maíra Kézia Freire 
Published: January 2024

Descrever os benefícios e técnicas do método canguru para o recém-nascido prematuro de baixo peso. Métodos: Trata-se de um estudo do tipo revisão integrativa coleta dos dados foi realizada nas bases a Biblioteca Virtual em Saúde (BVS) e SCIELO (Scientific Eletronic Library Online), através dos descritores: Método Canguru, recém-nascidos de baixo peso, recém-nascidos e enfermagem, sendo incluídos apenas os artigos completos e partir de 2016, em língua portuguesa. Resultados: A busca nas bases de dados resultou, após aplicação dos critérios de inclusão e exclusão, em apenas cinco que respondiam à questão de exploração, trazendo os benefícios e técnicos do método canguru, bem como a dificuldade de sua aplicação. Considerações finais: O Método Canguru apresenta benefícios em diversas áreas do desenvolvimento Neonatal, além de promover maior ligação entre mãe / pai e o neonato, para isso é necessário capacitar os profissionais de enfermagem e equipe multiprofissional para melhorar a assistência através da introdução de educação permanente e continuada para os profissionais de saúde sobre o método canguru.
Assessment of Solid Waste Disposal Practices and Management Strategies in Eke Okigwe Market, Imo State, Nigeria
Authors: Onuegbu Francis E. 
Published: January 2024

Effective solid waste management is necessary to safeguard environmental and public health in communities. However, inadequate disposal practices and facilities pose sustainability challenges in many locales. This study assesses waste management strategies and practices in Eke Okigwe Market, Nigeria. A mixed-methods approach was employed using survey of 220 participants found the most common primary disposal methods were burning (41.5%) and waste collection services (36.9%). Major challenges included inadequate infrastructure (42.2%), lack of storage facilities (22.5%), and insufficient collection (9.2%). Awareness of regulations was high (74.4%) but compliance varied from full (23.2%) to partial (46.4%). Vendors/owners (53.6%) and administrators (27.7%) were the main stakeholders, displaying moderate (50%) to limited (17.7%) collaboration. Air pollution (40.9%), health hazards (36.4%), and soil contamination (13.6%) were top environmental concerns. Semi-structured interviews revealed a mandatory biweekly collection program organized through unsanitary open dumps. An informal fee-based system operated via waste pickers. Governance required upgrade, as sub-administrators reported to an executive committee. Key findings were triangulated. Collection frequency significantly predicted disposal methods (R2=47.5%), with less improper disposal associated with higher frequency. Awareness positively correlated with compliance (r=.750). Disposal methods also correlated negatively with challenges faced (r=-.673) and collection frequency (r=-.689). This mixed methods case study characterized multifaceted waste management challenges. Upgrades to infrastructure, stakeholder integration, and education programs are needed for optimized, sustainable practices aligned with regulations through coordinated multi-level reforms.

Received: 16 November 2023 / Accepted: 28 December 2023 / Published: 5 January 2024
The Theoretical Foundation for the Development of a Conceptual Model on the Relationship between Succession Planning Practices, Employee Retention and Knowledge Management in HEIs
Authors: Bano Yasmeen , Omar Siti Sarah , Ismail Fadillha 
Published: January 2024

This paper addresses the importance of succession planning practices and provides a conceptual framework that organizations can apply to retain the best talent. The absence of comprehensive models for succession planning in higher education institutions is unfortunate. Therefore, this study reviews the literature and proposes a new comprehensive succession planning model for HEIs. A review of relevant theories identified three theoretical approaches that provide possible explanations for the relationship between succession planning and employee retention. In compiling the primary and non-research literature for this study, a variety of sources were used, including databases, online books, and published articles. Succession planning requires adequate human resources to develop future leaders due to the aging factor. The outcome of this study will assist human resources managers, policy makers and scholars to implement succession planning practices in the organization. Since there is a lack of research in HEIs context, this study can provide theoretical contribution for future researchers.

Received: 16 September 2023 / Accepted: 29 December 2023 / Published: 5 January 2024
Hubungan Kompetensi Perekam Medis dan Informasi Kesehatan dengan Kinerja dalam Melaksanakan Praktik Rekam Medis dan Informasi Kesehatan di Fasilitas Layanan Tingkat Pertama
Authors: Karmanto Bambang , Natalia Eri , Elfi Elfi 
Published: January 2024

Tujuan dari kompetensi adalah memperoleh suatu hasil dari dorongan atau motif yang dilakukan. Sementara itu, Kinerja merupakan fungsi yang melukiskan indikator dari kompetensi antara lain knowledge, skill, dan attitude. Dalam memberikan pelayanan atau melaksanakan kewajiban lainnya, petugas rekam medis harus melakukannya berdasarkan KMK No. 312 Tahun 2020. Tujuan penelitian ini adalah mengetahui hubungan antara kompetensi perekam medis dan informasi kesehatan dengan kinerja petugas rekam medis di puskesmas kota Cirebon 2022. Metode penelitian ini adalah observasional dengan pendekatan cross sectional. Sampel dalam penelitian ini adalah seluruh petugas rekam medis yang bekerja di wilayah kerja Puskesmas Dinas Kesehatan Kota Cirebon yang berjumlah 32 petugas rekam medis. Berdasarkan hasil uji univariat menyatakan bahwa kompetensi petugas rekam medis dalam kategori mampu sebanyak 50%. Kinerja petugas rekam medis dalam kategori baik sebanyak 59,4%. Hasil uji chi-square didapatkan nilai p-value sebesar 1,000 > 0,05. Artinya Tidak terdapat hubungan antara kompetensi PMIK dengan kinerja petugas rekam medis. Untuk meningkatkan kompetensi dan kinerja, petugas rekam medis mengikuti pelatihan, sosialisasi, diseminasi dan diskusi kasus.
Usia, Pendidikan, dan Penggunaan Aplikasi Kesehatan Berhubungan dengan Penerimaan Penggunaan Aplikasi Deteksi Penyakit Kronis
Authors: Widianawati Evina , Kusumawati Nugraheni , Wulan Widya Ratna , Pantiawati Ika 
Published: January 2024

Hasil pemeriksaan pasien yang mengikuti program Prolanis hanya tercatat di fasilitas pelayanan kesehatan, sedangkan pasien sendiri tidak mengetahui hasil pemeriksaannya. Untuk menjembatani hal tersebut dirancang aplikasi deteksi penyakit kronis. Ada beberapa faktor yang dapat mempengaruhi kesediaan pengguna untuk menggunakan aplikasi salah satunya yaitu karakteristik pengguna. Penelitian ini bertujuan untuk mengkaji hubungan karakteristik responden dengan penerimaan aplikasi deteksi penyakit kronis. Jenis penelitian yang digunakan adalah penelitian kuantitatif dengan lokasi penelitian yaitu di fasilitas pelayanan kesehatan di kabupaten semarang yaitu Puskesmas Lerep, Puskesmas Ungaran dan Klinik Niki Helti. Data diperoleh melalui kuesioner dengan skala linkert yang diisi oleh pasien di fasilitas pelayanan kesehatan sebagai pemakai sistem sebanyak 131 responden. Penelitian dilaksanakan bulan Juli-Agustus 2023. Teknik analisa data dengan menggunakan uji chi square dan uji rank spearman. Hasil penelitian menunjukkan bahwa terdapat hubungan usia (p.value 0,001), pendidikan (p.value 0,000), lama menggunakan mobile phone (p.value 0,001) dan penggunaan aplikasi kesehatan (p.value 0,012) terhadap penerimaan aplikasi deteksi penyakit kronis. Sedangkan jenis kelamin (p.value 0,051), pekerjaan (p.value 0,626) dan lama bekerja (p.value 0,293) tidak memiliki hubungan dengan penerimaan aplikasi deteksi penyakit kronis. Pada peneltian selanjutnya diharapkan aplikasi dibuat lebih mudah digunakan oleh pengguna usia lanjut, tidak sekolah dan belum pernah menggunakan mobile phone.
Laporan Pendahuluan Aktivitas Antioksidan Fraksi Etanol Daun Gatal (Laportea Decumman) dengan Metode 2,2-difenil-1-pikrilhidrazil
Authors: Lerebulan Exaudian , Marasabessy Hadija 
Published: January 2024

Laportea decumana yang biasa disebut oleh masyarakat sebagai daun gatal sudah secara turun-temurun digunakan oleh masyarakat Papua sebagai obat antinyeri (WHO, 2009). Di dalam tubuh sendiri terdapat mekanisme antioksidan atau antirdikal bebas (Dyatmiko dkk., 2000), yang berfungsi melindungi tubuh terhadap serangan radikal bebas, yang dibentuk oleh beberapa enzim antioksidan dalam tubuh seperti superoksida dismutase, katalase dan glutasion peroksidase, pada hasil uji skrining fitokimia, daun gatal mengandung senyawa golongan alkaloid, flavonoid, tanin, glikosida dan steroid/triterpenoid (Simaremare, 2014; Hestiningtyas, dkk 2019). kategori IC50 yang baik adalah kurang dari 50-100 µg/mL. Tujuan penelitian ini adalah mengetahui efektivitas antioksidan fraksi etanol tanaman daun gatal (Laportea decumana) menggunakan metode DPPH. Metode penelitian yang digunakan adalah menggunakan metode DPPH dengan menggunakan tingkat kepolaran yang berbeda yaitu menggunakan N-Heksan, Etil Asetat, Air serta Vitamin C (sebagai control positif) dengan 3x replikasi. Hasil penelitian menunjukkan bahwa rata-rata nilai IC50 di bawah kontrol positif (Vitamin C sebesar 58,24 µg/mL) dimana frakasi N-heksan sebesar 5.030 µg/mL, fraksi etil asetat 5.969 µg/mL dan fraksi air 7.870 µg/mL. Hasil dari penelitian menunjukkan bahwa ketiga fraksi tersebut memiliki aktivitas antioksidan yang lemah jika dibandingkan dengan control positif.
Efektivitas Antibakteri Ekstrak Daun Okra Hijau (Abelmoschus Esculentus (L.) Moench) Var. Naila) Terhadap Staphylococcus Aureus
Authors: Roddu Ajeng Kurniati , Isnaeni Dewi , Baharuddin Suherman 
Published: January 2024

Penyajian: Obat diketahui bahwa zat yang dapat menghambat perkembangan atau bahkan membunuh mikroorganisme dengan cara menghambat pencernaan organisme perusak. Salah satu tumbuhan yang bisa dimanfaatkan diketahui bahwatumbuhan Okra, untuk itu tumbuhan Okra Berwarna (Abelmuschus escolentus (L.) Muench) Var. Nayla. Tujuan: mengetahui dampak obattumbuhan Okra terhadap Staphylucoccus aoreus dan menentukan konvergensi terbaik dari buatantumbuhan Okra Berwarna (Abelmuschus escolentus (L.) Muench ) Var. Nayla Melawan Staphylucoccus aoreus. Teknik: Eksplorasi ini menggunakan strategi eksplorasi yaitu penelitian di laboratorium untuk mengetahui viabilitas buatantumbuhan Okra Berwarna (Abelmuschus escolentus (L.) Muench ) Var. Nayla melawan Staphylucoccus aoreus. Pengtesan dilakukan dengan menggunakan kelompok buatantumbuhan Okra Berwarna 2 persenb.v, 4 persenb.v, 6 persenb.v menggunakan teknik penyebaran agar. Hasil: Buatan tumbuhan okra berwarna (Abelmuschus escolentus Var. Nayla ) mempunyai khasiat sebagai obat terhadap Staphylucoccus aoreus dan konvergensi tumbuhan okra berwarna (Abelmuschus escolentus Var. Nayla ) paling baik dalam menghambat Staphylucoccus aoreus , khususnya pada kelompok luas 6 persenb.v. zona obstruksi 37,3 millimeter.
Cervical Cancer Papsmear Classification through Meta-Learning Technique using Convolution Neural Networks.
Authors: Mahendra M , Jumadi J , Riana Dwiza 
Published: January 2024

This study uses convolutional neural networks (CNNs) and meta-learning techniques to create an accurate and efficient model for classifying the risk factors of cervical cancer. The dataset includes four types of cervical lesions, and the main objective is to categorize these lesions as either benign or malignant. This classification is essential for early and succesfull treatment of cervical cancer. The challenge arises from the complexity and variations in the images, resulting in the inability of conventional machine learning and deep learning approaches to provide correct classifications. Meta ensemble learning approaches are employed to improve the model's classification accuracy. The dataset of cervical cancer risk factors is preprocessed before being used to train and evaluate numerous CNNs utilizing pre-trained models and various architectures. Subsequently, a meta-learning is employed to optimize the learning process, and used to aggregate the outputs of the multiple CNNs. Moreover, the assessment findings show the model achieves high accuracy and effectiveness. Finally, the suggested model's accuracy score will be contrasted against the current cutting-edge methods used by other existing systems.