bluuebunny/crossref_metadata_2025_split huggingface dataset:
Museums Institutions as A Proposal for Regional, Economic and Social Development: The Museu do Amanhã
Authors: Sandy Danielly Dias , De Lima Isaura Alberton , Duenhas Rogério Allon 
Published: January 2024

Objective: To carry out this study, the objective was to address the main impacts of the Museu do Amanhã on regional development since its inauguration on 2015, in the port region of the city of Rio de Janeiro-RJ.

Theoretical reference: As defined in Article 1 of Federal Law 11.904, and in accordance with the guidelines of the International Council of Museums (ICOM), museums are non-profit institutions that work at the service of societies (2009). However, museums are also importante cultural facilities that can be well used according to urban and regional strategic planning to revitalize certain areas. Likewise, museums can make theis contribution based on impacts generated by the greather flow of people in the region with increased tourism, which can result in significant regional, economic and social development.

Method: This study is based on exploratory and descriptive research dealing with the impacts of the Museu do Amanhã on regionaldevelopment, based on bibliographic sources and data and whose analysis method applied was a qualitative approach to analyze the proposed phenomenon.

Results and conclusion: The current analysis leads to the conclusion that the Museu do Amanhã brought significant regional impacts, both economic and social and cultural. However, from bibliographical sources of the time, it was observed that there are signs of gentrifyng action in the processo f revitalization of the region where the museum was built, which cannot, under any circumstances, be related to the real purposes of a museum institution. And this is because museums have as their mission the purpose of working for the promotion of humanity and the establishment of peace. At the same time, museums are also strategic instruments for urban and regional planning and this contexto opens up countless analyzes and discussions.

Implications of the research: This study presents important questions focused on the relationship between musems and urban and regional planning, opening up new research and proposing further discussions and analyzes on the topic.

Originality/value: The field of museology is quite comprehensive, and its multidisciplinar and interdisciplinar character must also be taken into account. Even so, mosto f the time research is carried out that delas more with the activities carried out within museums such as conservation, research, exhibition and educational action, but there are other ways of thinking about a museum for society and regarding this there are still manygaps that nees be filled. One possibility on this path is precisely to carry out research with proposals that recognize museums in another way, for example, as strategic instruments for urban and regional planning.
استخدام تمرينات تعليمية مقترحة وفق الأسلوب التبادلي بوسائل إيضاحية مساعدة وتأثيرها في رفع مستوى أداء مهارتي المناولة الصدرية من الحركة والتهديف من القفز بكرة السلة لمنتخب ناشئي محافظة الأنبار
Authors: خلف عبود عامر 
Published: January 2024

تهدف الدراسة إلى تصميم تمرينات تعليمية مقترحة وفق الأسلوب التبادلي باستخدام بعض الوسائل الإيضاحية المساعدة ومدى تأثيرها على عينة البحث التجريبية لرفع مستوى أداء مهارتي المناولة الصدرية من الحركة والتهديف من القفز بكرة السلة (قيد الدراسة) حيث تم استخدام الباحث المنهج التجريبي لملائمة طبيعة المشكلة وفق تصميم المجموعة الواحدة ذات الاختبارين (القبلي – البعدي) على عينة مختارة بالطريقة العمدية وهي منتخب ناشئي محافظة الأنبار بكرة السلة والتي تتراوح أعمارهم ما بين (17 - 16) سنة والبالغ عددهم (16) لاعباً تم استبعاد (6) لاعبين منهم بسبب اشتراكهم بالتجربة الاستطلاعية ولأسباب أخرى وبذلك أصبحت العينة التجريبية (10) لاعبين وبنسبة مئوية قدرها (5٫62٪) وعلية تم تطبيق التجربة الرئيسية لمدة (8) أسابيع بواقع (24) وحدة تعليمية أي في كل أسبوع (3) وحدات تعليمية ومن خلال عرض النتائج ومن ثم تحليلها توصل الباحث إلى عدة استنتاجات كان أهمها أن تصميم وتطبيق التمرينات المقترحة وفق الأسلوب التبادلي على عينة البحث كانت ذو فائدة ولها الأثر الكبير في تعلم هذه العينة بعض المهارات الهجومية بكرة السلة وإن أهم ما أوصى به الباحث هو استخدام الأسلوب التبادلي في بحوث أخرى وفق المستويات الرياضية والفئة العمرية المناسبة
بناء مقياس استراتيجيات التنظيم الانفعالي للاعبات أندية كرة القدم الصالات
Authors: مهدي كاظم سناء , احمد جاسم عبد المنعم , خير الدين صالح محمد 
Published: January 2024

- بناء مقياس استراتيجيات التنظيم الانفعالي للاعبات أندية كرة القدم الصالات .
أستعمل الباحثون المنهج الوصفي بأسلوبي (المسح والعلاقات الارتباطية)،تكون مجتمع البحث من لاعبات أندية كرة القدم الصالات في دوري كوردستان العراق للمتقدمات المشاركات في منافسات الدوري الممتاز للموسم الرياضي (2020-2021م ) والبالغ عددهن(144) لاعبة موزعات على (10) أندية، واستخدم الباحثون ادوات لجمع البيانات وهي بناء مقياس استراتيجيات التنظيم الانفعالي للاعبات أندية كرة القدم الصالات، وقام الباحثون بمعالجة البيانات التي تم الحصول عليها من خلال عدد من الوسائل الاحصائية وبوساطة الحقيبة الاحصائية (SPSS).
توصل الباحثون الى أهم الاستنتاجات الاتية :

تميزت عينة البحث بمستوى جيد في بعض استراتيجيات التنظيم الانفعالي لدى لاعبات كرة القدم الصالات.

يوصي الباحثون بالآتي:

ضرورة استخدام مقياس استراتيجيات التنظيم الانفعالي الذي تم بناؤه لتقييم مستوى لاعبات أندية كرة القدم الصالات.

إجراء دراسات مشابهة للدراسة الحالية وعلى لاعبي أندية كرة القدم الصالات.
تأثير تمرينات مهارية بالأسلوب التنافسي في تعلم بعض المهارات الاساسية بكرة القدم للصالات لطلاب الصف الاول متوسط
Authors: داود سلمان رائد 
Published: January 2024

إذ تأتي أهمية البحث من خلال استخدام أسلوب التنافس في التعلم والذي يدفع الطالب إلى بذل اكبر قدر ممكن من الجهد في تعلم المهارات، ومن خلال خبرة الباحث في مجال لعبة كرة القدم للصالات ولأهمية الرياضة المدرسية كونها الحلقة الاولى في سلسلة البناء المهاري الصحيح لاحظ ان تعلم المهارات الاساسية لا يتم بالشكل المناسب وكذلك ان التمرينات المستخدمة في تعلم المهارات الاساسية تفتقر الى تحقيق جانب الاثارة والتشويق والذي يعتبر المحرك الاساسي نحو اقبال المتعلمين نحو الاداء ، لذا ارتأى الباحث استعمال تمرينات مهارية تنافسية في تعلم بعض المهارات الاساسية بكرة القدم للصالات لطلاب الصف الاول متوسط كمحاولة منهما في ايجاد طريقة فعالة في تعلم الطلاب لتلك المهارات بالشكل المناسب ، واستخدام الباحث المنهج التجريبي تصميم المجموعتين المتكافئتين ، وقد تكونت عينة البحث من طلاب الصف الاول متوسط ( ثانوية الابداع للمتفوقين ) والبالغ عددهم ( 47 ) طالب ، وبعد الانتهاء من التجربة الميدانية توصل الباحث الى ان طريقة الاسلوب التنافسي الذي تتشابه تمريناته مع ظروف المنافسة الحقيقة ساهم في زيادة اندفاع الطلبة نحو الاداء مما ساهم في تعلم المهارات الأساسية بكرة القدم للصالات.
The effect of skill exercises according to sensory modeling in learning some basic skills in futsal football for fourth grade middle school students
Authors: Gazi Ahmed Ammar , Ismael Jumea Hujum 
Published: January 2024

Abstract:
The importance of the research lies in the interest in modern methods that take into account the individual differences among the learners and in choosing the most appropriate curricula and exercises that lead to achieving the goals in the least effort and the shortest time. As for the research problem, it lies in the weakness of the basic skills in the game of futsal, and it was found that the educational curriculum followed is a curriculum that does not take into account the representative system of the learner who receives information or in choosing the representative system in the lesson plan. The aim of the research is to identify the impact of skill exercises according to sensory modeling in learning some basic skills in futsal. As the researcher used the experimental method, and the researcher followed the design of equal groups, while the research sample was from middle school students. The main experiment was carried out for the period from (3/3/2022 to 4/21/2022), and its duration was (7 weeks), with (2) two educational units per week. After completing the experiment, the researcher reached the most important conclusions that the skillful exercises used were effective in improving the skill aspect. As for the most important recommendations, it was the need to introduce teachers to the preference of sensory modeling for students, and to develop educational curricula according to the degrees of representative systems for them.
Dapsone and Sulfasalazine as Adjuvant Therapies in Pemphigus Vulgaris: A Systematic Review
Authors: Nguyen Kevin , Norman Thomas , Worswick Scott 
Published: January 2024

Background: Adjuvant treatments are often employed in pemphigus vulgaris (PV) to reduce dependence on corticosteroids. When first-line adjuvants are ineffective, considering alternative adjuvant therapies may be necessary. Dapsone and sulfasalazine represent two options.
Objective: To evaluate the use of dapsone and sulfasalazine in the treatment of PV.
Methods: A PubMed search identified patients with PV treated with dapsone or sulfasalazine. We included all studies with ≥3 patients published in English between 1980 and December 2022. Clinical improvement was defined as disease control or complete remission (when adjuvant therapy was initiated in uncontrolled disease) and as a reduction of corticosteroids to ≤7.5 mg per day (when adjuvant therapy was initiated in controlled disease).
Results: Eleven studies were identified representing 75 patients treated with dapsone and 66 patients treated with sulfasalazine. Six patients received dapsone monotherapy, and all had clinical improvement. Sixty-nine received adjuvant dapsone, leading to clinical improvement in 40 (58%). Fifty-seven patients received sulfasalazine as an adjuvant to intravenous corticosteroids, leading to clinical improvement in 49 (86%). The remaining 9 patients received sulfasalazine following rituximab, and all had clinical improvement.
Conclusions: Dapsone and sulfasalazine have evidence supporting their efficacy and can be considered when first-line adjuvant therapies are unsuccessful.
Artificial Intelligence in Dermatology: A Review of Literature and Application to Pediatric Dermatology
Authors: Burshtein Joshua , Gnarra Buethe Maria 
Published: January 2024

Background: Artificial intelligence (AI) is increasingly investigated for use in dermatologic conditions. We review recent literature on AI, its potential application for pediatric dermatology, and its impact on the underserved community.
Objective: To evaluate the current state of AI in dermatology and its application to pediatric patients.
Methods: Literature search was performed in PubMed and Google Scholar using the following key terms in combination with "pediatric", and "dermatology": "artificial intelligence," "AI," "machine learning," "augmented intelligence," "neural network," and "deep learning".
Results: Current research is based on images from adult databases, with minimal delineation of patient age. Most literature on AI and dermatologic conditions pertains to melanoma and non-melanoma skin cancers, reporting accuracy from 67-99%. Other commonly studied diseases include psoriasis, acne vulgaris, onychomycosis, and atopic dermatitis, having varying accuracy, sensitivity, and specificity. A recently developed AI algorithm for diagnosis of infantile hemangioma found 91.7% accuracy. AI may be a means to increase access to pediatric dermatologic care, yet challenges remain for its use in underserved communities.
Conclusion: Literature on AI systems for dermatologic diseases continues to grow. Further research may tailor AI algorithms for pediatric patients and those of diverse skin color to decrease algorithm bias and increase diagnostic accuracy.
Hidradenitis Suppurativa Disease Severity and Outcomes Among Black Patients from Low-Income Neighborhoods at a Tertiary Care Hospital: A Retrospective Review
Authors: Catinis Anna , Gioe Olivia , Savoie Caroline , Rosen Erika , Hilton Deborah 
Published: January 2024

Hidradenitis suppurativa (HS) is a debilitating, inflammatory condition of apocrine sweat glands. Black patients are disproportionately affected, a finding largely attributed to lower socioeconomic status (SES) in the literature; yet, most HS studies include majority White cohorts. We present, to our knowledge, the first retrospective review of an entirely Black patient population living in low-income neighborhoods diagnosed with hidradenitis suppurativa (HS) to identify potentially modifiable factors related to disease severity and outcomes. We reviewed charts of Black patients with an encounter for HS from 2010-2020 in the New Orleans University Medical Center database. HSt III disease was associated with early and chronic onset, longer time-to-treatment, higher body mass index, and Medicaid insurance. Flared disease was associated with fewer dermatology visits, more incision and drainage procedures, and higher lost-to-follow-up rates while well-controlled patients had more surgical excisions, biologic use, and lower smoking rates. Patients were nearly evenly split among initial Hurley stages (HSt), and ~50% of the 473 patients were stable or well-controlled at latest disease status, suggesting low SES alone cannot explain HS race-based discrepancies. Our findings highlight potentially modifiable factors for healthcare providers to consider when holistically treating Black patients living in low-SES communities.
Roflumilast Cream 0.3% in Patients with Chronic Plaque Psoriasis: Individual Patient Response from the Pooled DERMIS-1 and DERMIS-2 Phase 3 Trials
Authors: Del Rosso James , Hong H. Chih-ho , Kircik Leon , Gooderham Melinda , Lebwohl Mark , Papp Kim , Stein Gold Linda , Hebert Adelaide , Seal Melissa , Krupa David , Chu David , Burnett Patrick , Berk David , Higham Robert 
Published: January 2024

Roflumilast cream 0.3% in patients with chronic plaque psoriasis: individual patient response from the pooled DERMIS-1 and DERMIS-2 phase 3 trials

James Del Rosso1 on behalf of the authors

INTRODUCTION: Roflumilast cream 0.3% is a highly potent phosphodiesterase 4 inhibitor approved as a nonsteroidal, once-daily treatment for patients with plaque psoriasis. The efficacy and safety of the pooled results of two Phase 3 clinical trials (DERMIS-1 and DERMIS-2) in patients aged ≥2 years with plaque psoriasis have been previously presented. We present individual patient responses using the Psoriasis Area and Severity Index (PASI).
METHODS: Patients aged ≥2 years with at least mild plaque psoriasis involving 2-20% of body surface area were randomized 2:1 to apply roflumilast cream 0.3% or vehicle cream once daily for 8 weeks. The primary efficacy endpoint was Investigator Global Assessment (IGA) Success (score of Clear or Almost Clear plus ≥2-grade improvement from baseline) at Week 8; IGA of Clear or Almost Clear was a secondary endpoint. PASI was used to measure disease severity; individual patient PASI responses were plotted graphically. Safety and tolerability were also evaluated and have been previously reported.
RESULTS: Roflumilast- and vehicle-treated patients had similar baseline demographic and disease characteristics. At Week 8, statistically significantly more roflumilast- than vehicle-treated patients achieved IGA Success (39.9% vs. 6.5%; P<0.0001) and IGA of Clear or Almost Clear (48.0% vs. 9.5%; nominal P<0.0001). Statistically significant differences favoring roflumilast were observed at Week 8 for percentages of patients achieving a 50% reduction in PASI (72.1% vs. 25.5%; P<0.0001), 75% reduction (40.3% vs. 6.5%, P<0.0001), 90% reduction (19.7% vs 2.3%; P<0.0001), and 100% reduction (12.3% vs 0.8%; P<0.001). At the first post-treatment timepoint evaluated (Week 2), 85.7% of roflumilast-treated patients had a measurable improvement in PASI, increasing to 95.0% by the last timepoint (Week 8). Roflumilast cream demonstrated low rates of application-site adverse events (AEs), treatment-related AEs, and discontinuations due to AEs, comparable with vehicle. Approximately 96% of patients reported no or mild sensation after the first application of roflumilast cream 0.3%, improving to more than 99% of patients at Week 4 and Week 8, similar to vehicle.
CONCLUSIONS: Roflumilast cream 0.3% provided greater improvement in IGA Success, IGA of Clear or Almost Clear, and PASI versus vehicle with favorable safety and tolerability in patients with psoriasis in two Phase 3 trials.
Sponsored by Arcutis Biotherapeutics, Inc.
ClinicalTrials.gov Identifiers: DERMIS-1: NCT04211363; DERMIS-2: NCT04211389
Comparison of Study Designs for Primary Phase III Trials for Omalizumab Versus Dupilumab for Patients With Chronic Spontaneous Urticaria
Authors: Alexis Andrew , Anders Kyle , Seetasith Arpamas , Holden Michael 
Published: January 2024

Introduction
Omalizumab is currently the only biologic approved and recommended as second-line treatment for patients with chronic spontaneous urticaria (CSU). However, clinical trial programs are underway for other biologic treatments such as dupilumab. Given head-to-head trials will not be conducted, consideration of study design may be important.
Methods
Comparison of participants, interventions, outcomes, and results for phase III primary efficacy clinical trials for omalizumab versus dupilumab for patients with CSU. The omalizumab trials were ASTERIA I/II (NCT01287117 and NCT01292473) and the dupilumab trial was LIBERTY-CSU CUPID (NCT04180488) that consisted of Study A, B, and C.
Results
Participants in ASTERIA I/II were 12 to 75 years with a diagnosis of CSU refractory to H1 antihistamines. Participants in LIBERTY-CSU CUPID were 6 to 80 years (Study A and C) or 12 to 80 years (Study B) with a diagnosis of CSU refractory to H1 antihistamines, and Urticaria Activity Score (UAS)7≥16 and Itch Severity Score (ISS)7≥8 during the 7 days before randomization; Study A and C included participants who were omalizumab naïve and Study B included intolerant or incomplete responders to omalizumab. For ASTERIA I and II, the interventions were placebo or omalizumab (75mg, 150mg, 300mg) every 4 weeks for 24 and 12 weeks, respectively. For LIBERY-CSU CUPID, the interventions were placebo or dupilumab (200mg or 300mg, weight based) every 2 weeks for 24 weeks. The primary efficacy outcome for ASTERIA I/II was change from baseline in ISS7 at Week 12. The primary efficacy outcome for LIBERTY-CSU CUPID was change from baseline in ISS7 at Week 24. For the ASTERIA I primary outcome, the change from baseline in ISS7 at Week 12 was -3.6 for placebo and -6.5, -6.7, and ‑9.4 for omalizumab 75mg, 150mg, and 300mg, respectively. For the ASTERIA II primary outcome, the change from baseline in ISS7 at Week 12 was -5.1 for placebo and ‑5.9, ‑8.1, and ‑9.8 for omalizumab 75mg, 150mg, and 300mg, respectively. For the LIBERTY-CSU CUPID Study A primary outcome, the change from baseline in ISS7 at Week 24 was ‑6.0 for placebo and -10.2 for dupilumab. The LIBERTY-CSU CUPID Study B was stopped due to futility based on a pre-specified interim analysis.
Conclusion
Comparing study designs for primary clinical trials for omalizumab and dupilumab for patients with CSU will aid in the comparative analysis and clinical evaluation of final trial results.
Funding: ASTERIA I/II were funded by Genentech Inc. and Novartis Pharma AG.
Clinical Evaluation of Next-Generation, Multi-Weight Hyaluronic Acid Plus Antioxidant Complex-Based Topical Formulations with Targeted Delivery to Enhance Skin Rejuvenation
Authors: Romanowitz Daniel , Lain Edward , Mariwalla Kavita , Zeichner Joshua , Kirchner Frank , Ruvolo Eduardo , Draelos Zoe 
Published: January 2024

Introduction: Hyaluronic acid (HA) has become a commonly used ingredient in many topical moisturizing products due to its strong humectant properties and essential role in skin hydration; however, limitations of delivery of HA to only the surface of skin has hindered leveraging the full capacity of HA biology necessary for skin rejuvenation. Here we describe the clinical efficacy data of a set of novel next-generation, multi-weight HA plus antioxidant complex-based topical formulations with targeted skin delivery to enhance skin rejuvenation, giving a youthful, healthy appearance.
Methods: Four multi-weight HA plus antioxidant complex-based formulations: 1) Multi-Weight HA plus Antioxidant Complex Cream with SPF 30 (Day Cream); 2) Multi-Weight HA plus Antioxidant Complex Cream (Night Cream); 3) Multi-Weight HA plus Antioxidant Complex Gel Cream; and 4) Multi-Weight HA plus Antioxidant Complex Boost Serum were clinically evaluated for key attributes including moisturization via corneometer, with clinical grading of: dryness, roughness, fine lines and wrinkles, and following daily use of the individual products for up to 8 weeks.
Results: Daily use of the multi-weight HA plus antioxidant complex-based formulations demonstrated significant improvements in all parameters evaluated compared to baselines, with changes in moisturization observed within 30 minutes of application, and changes in clinical grading parameters of dryness, roughness, fine lines and wrinkles observed as early as 2 weeks.
Conclusions: These data demonstrate the clinical benefits of daily use of multi-weight HA plus antioxidant complex-based moisturizers for overall improvement in skin health and appearance.
Early Repigmentation of Stable Vitiligo through Point-of-Care Melanocyte Transfer Using Non-Cultured Autologous Skin Cell Suspension
Authors: Madhusudhan Malini 
Published: January 2024

Introduction: Vitiligo is an acquired depigmenting skin condition characterized by the loss of skin pigmentation, impacting 0.5% to 2% of the global population.1,2 Vitiligo presents as distinct depigmented patches resulting from autoimmune melanocyte destruction. Individuals with visual vitiligo lesions often experience negative body image, diminished self-confidence, discomfort, and overall lower quality of life (QoL).3 While there are medical treatment options available, these can be associated with poor efficacy and low medication compliance.4 Residual lesions after treatment may require surgical intervention which allows for melanocyte transplantation from an area that is pigmented to one that is lacking functional melanocytes. Through a point-of-care device, a non-cultured autologous skin cell suspension (ACSC) can be prepared using a small skin sample; the ASCS contains healthy melanocytes and is immediately applied onto skin treated with ablative laser to aid in the repigmentation of affected areas. The objective of this study was to evaluate the one-time application of ASCS, with a 1:20 donor to treatment site expansion ratio, for the safe and effective repigmentation of stable vitiligo lesions.
Methods: A randomized, within-subject controlled, central observer-blinded study was conducted to compare the clinical performance of laser ablation, ASCS, and NB-UVB to NB-UVB alone for repigmentation of stable vitiligo lesions in adults. Subjects received NB-UVB phototherapy on both ASCS-treated and controlled lesions as per recommended by the Vitiligo Working Group. Repigmentation of ASCS-treated and control lesions were categorized by a Central Review Committee (CRC) of blinded dermatologists as one of the following: 0%-25%, 26%-50%, 51%-79%, or 80-100%. The primary effectiveness endpoint was defined as the proportion of lesions achieving ≥80% repigmentation for ASCS-treated versus control areas at Week 24. Early regimentation was assessed at Weeks 4 and 12 as a post hoc analysis.
Results: A significantly higher proportion of the ASCS-treated areas (36.0%, n = 9) compared to control-treated areas (0.0%) attained ≥80% repigmentation at Week 24 (P = 0.012). At Week 4, 30.4% (n = 7/23) of ASCS-treated areas had ≥26% repigmentation compared to 4.3% (n = 1/23) in the control areas. At Week 12, 56.5% (n = 13/23) of ASCS-treated areas had ≥26% repigmentation compared to 21.7% (n = 5/23) in the control areas. At Week 24, 64% (n = 16/25) of ASCS-treated areas had ≥26% repigmentation compared to 28% (n = 7/25) in the control areas.
Conclusion: A one-time treatment of ASCS, with the addition of NB-UVB, can result in excellent repigmentation results by 24 weeks, with most subjects seeing ≥26% repigmentation as early as 4 to 12 weeks.