bluuebunny/crossref_metadata_2025_split huggingface dataset:
Cross-cultural invariance of the Spanish version of the COVID-19 Assessment Scorecard to measure the perception of government actions against COVID-19 in Latin America
Authors: Caycho-Rodríguez Tomás , Valencia Pablo D. , Ventura-León José , Carbajal-León Carlos , Vilca Lindsey W. , Reyes-Bossio Mario , Delgado-Campusano Mariel , Yupanqui-Lorenzo Daniel E. , Paredes-Angeles Rubí , Rojas-Jara Claudio , Gallegos Miguel , Cervigni Mauricio , Martino Pablo , Polanco-Carrasco Roberto , Palacios Diego Alejandro , Moreta-Herrera Rodrigo , Samaniego-Pinho Antonio , Lobos Rivera Marlon Elías , Buschiazzo Figares Andrés , Puerta-Cortés Diana Ximena , Corrales-Reyes Ibraín Enrique , Calderón Raymundo , Arias Gallegos Walter L. , Petzold Olimpia , Camargo Andrés , Torales Julio , Monge Blanco J. Arkangel , González Pedronel , Smith-Castro Vanessa , Matute Rivera Wendy Yamilet , Ferrufino-Borja Daniela , Ceballos-Vásquez Paula , Muñoz-del-Carpio-Toia Agueda , Palacios Jorge , Burgos-Videla Carmen , Florez León Ana María Eduviges , Vergara Ibeth , Vega Diego , Barria-Asenjo Nicol A. , Schulmeyer Marion K. , Urrutia Rios Hassell Tatiana , Lira Lira Arelly Esther 
Published: November 2023

Abstract
Objectives
The present study aimed to evaluate the measurement invariance of a general measure of the perception of governmental responses to COVID-|19 (COVID-SCORE-10) in the general population of 13 Latin American countries.

Methods
A total of 5780 individuals from 13 Latin American and Caribbean countries selected by non-probabilistic snowball sampling participated. A confirmatory factor analysis was performed and the alignment method was used to evaluate invariance. Additionally, a graded response model was used for the assessment of item characteristics.

Results
The results indicate that there is approximate measurement invariance of the COVID-SCORE-10 among the participating countries. Furthermore, IRT results suggest that the COVID-SCORE-10 measures with good psychometric ability a broad spectrum of the construct assessed, especially around average levels. Comparison of COVID-SCORE-10 scores indicated that participants from Cuba, Uruguay and El Salvador had the most positive perceptions of government actions to address the pandemic. Thus, the underlying construct of perception of government actions was equivalent in all countries.

Conclusion
The results show the importance of initially establishing the fundamental measurement properties and MI before inferring the cross-cultural universality of the construct to be measured.
The impact of image augmentation techniques of MRI patients in deep transfer learning networks for brain tumor detection
Authors: Abdalla Peshraw Ahmed , Mohammed Bashdar Abdalrahman , Saeed Ari M. 
Published: November 2023

AbstractThe exponential growth of deep learning networks has enabled us to handle difficult tasks, even in the complex field of medicine. Nevertheless, for these models to be extremely generalizable and perform well, they need to be applied to a vast corpus of data. In order to train transfer learning networks with limited datasets, data augmentation techniques are frequently used due to the difficulties in getting data. The use of these methods is crucial in the medical industry in order to enhance the number of cancer-related magnetic resonance imaging pathology scans. This study evaluates the results of data augmentation methods on three deep transfer learning networks, such as InceptionV3, VGG16, and DenseNet169, for brain tumor identification. To demonstrate how data augmentation approaches affect the performance of the models, networks were trained both before and after the application of these methods. The outcomes revealed that the image augmentation strategies have a big impact on the networks before and after using techniques, such as the accuracy of VGG16 is 77.33% enhanced to 96.88%, and InceptionV3 changed from 86.66 to 98.44%, and DenseNet169 changed from 85.33 to 96.88% the accuracy percentage increase of the models are 19.55%, 11.78%, and 11.55%, respectively.
Algorithmic fairness in precision psychiatry: analysis of prediction models in individuals at clinical high risk for psychosis
Authors: Şahin Derya , Kambeitz-Ilankovic Lana , Wood Stephen , Dwyer Dominic , Upthegrove Rachel , Salokangas Raimo , Borgwardt Stefan , Brambilla Paolo , Meisenzahl Eva , Ruhrmann Stephan , Schultze-Lutter Frauke , Lencer Rebekka , Bertolino Alessandro , Pantelis Christos , Koutsouleris Nikolaos , Kambeitz Joseph ,   for the PRONIA Study Group
Published: November 2023

BackgroundComputational models offer promising potential for personalised treatment of psychiatric diseases. For their clinical deployment, fairness must be evaluated alongside accuracy. Fairness requires predictive models to not unfairly disadvantage specific demographic groups. Failure to assess model fairness prior to use risks perpetuating healthcare inequalities. Despite its importance, empirical investigation of fairness in predictive models for psychiatry remains scarce.AimsTo evaluate fairness in prediction models for development of psychosis and functional outcome.MethodUsing data from the PRONIA study, we examined fairness in 13 published models for prediction of transition to psychosis (n = 11) and functional outcome (n = 2) in people at clinical high risk for psychosis or with recent-onset depression. Using accuracy equality, predictive parity, false-positive error rate balance and false-negative error rate balance, we evaluated relevant fairness aspects for the demographic attributes ‘gender’ and ‘educational attainment’ and compared them with the fairness of clinicians’ judgements.ResultsOur findings indicate systematic bias towards assigning less favourable outcomes to individuals with lower educational attainment in both prediction models and clinicians’ judgements, resulting in higher false-positive rates in 7 of 11 models for transition to psychosis. Interestingly, the bias patterns observed in algorithmic predictions were not significantly more pronounced than those in clinicians’ predictions.ConclusionsEducational bias was present in algorithmic and clinicians’ predictions, assuming more favourable outcomes for individuals with higher educational level (years of education). This bias might lead to increased stigma and psychosocial burden in patients with lower educational attainment and suboptimal psychosis prevention in those with higher educational attainment.
Barker's Hypothesis Among the Global Poor: Positive Long-Term Cardiovascular Effects of in Utero Famine Exposure
Authors: Ciancio Alberto , Behrman Jere , Kämpfen Fabrice , Kohler Iliana V. , Maurer Jürgen , Mwapasa Victor , Kohler Hans-Peter 
Published: November 2023

Abstract
An influential literature on the Developmental Origins of Health and Disease (DOHaD) has documented that poor conditions in utero lead to higher risk of cardiovascular disease at older ages. Evidence from low-income countries (LICs) has hitherto been missing, despite the fact that adverse in utero conditions are far more common in LICs. We find that Malawians exposed in utero to the 1949 Nyasaland famine have better cardiovascular health 70 years later. These findings highlight the potential context specificity of the DOHaD hypothesis, with in utero adversity having different health implications among aging LIC individuals who were exposed to persistent poverty.
Tenosynovial giant cell tumours: experience at an Australian tertiary referral centre for musculoskeletal tumours with minimum two-year follow-up
Authors: Kim Raymond G. , Maher Anthony W. , Karunaratne Sascha , Stalley Paul D. , Boyle Richard A. 
Published: November 2023

AimsTenosynovial giant cell tumour (TGCT) is a rare benign tumour of the musculoskeletal system. Surgical management is fraught with challenges due to high recurrence rates. The aim of this study was to describe surgical treatment and evaluate surgical outcomes of TGCT at an Australian tertiary referral centre for musculoskeletal tumours and to identify factors affecting recurrence rates.MethodsA prospective database of all patients with TGCT surgically managed by two orthopaedic oncology surgeons was reviewed. All cases irrespective of previous treatment were included and patients without follow-up were excluded. Pertinent tumour characteristics and surgical outcomes were collected for analysis.ResultsThere were 111 total cases included in the study; 71 (64%) were female, the mean age was 36 years (SD 13.6), and the knee (n = 64; 57.7%) was the most commonly affected joint. In all, 60 patients (54.1%) had diffuse-type (D-TGCT) disease, and 94 patients (84.7%) presented therapy-naïve as "primary cases" (PC). The overall recurrence rate was 46.8% for TGCT. There was a statistically significant difference in recurrence rates between D-TGCT and localized disease (75.0% vs 13.7%, relative risk (RR) 3.40, 95% confidence interval (CI) 2.17 to 5.34; p < 0.001), and for those who were referred in the ”revision cases” (RC) group compared to the PC group (82.4% vs 48.9%, RR 1.68, 95% CI 1.24 to 2.28; p = 0.011). Age, sex, tumour volume, and mean duration of symptoms were not associated with recurrence (p > 0.05).ConclusionRecurrence rates remain high even at a tertiary referral hospital. Highest rates are seen in D-TGCT and “revision cases”. Due to the risks of recurrence, the complexity of surgery, and the need for adjuvant therapy, this paper further supports the management of TGCT in a tertiary referral multi-disciplinary orthopaedic oncology service.Cite this article: Bone Jt Open 2023;4(11):846–852.
Development of a Radio-Frequency Technology for the Decontamination of Salmonella from Timothy Hay
Authors: Smith Deandrae , Wason Surabhi , Bruce Rebecca , Atungulu Griffiths 
Published: November 2023

Highlights

After inoculation with the Salmonella spp. cocktail and E. faecium, timothy hay samples had an initial microbial load of 7.81 and 7.75 log CFU/g, respectively.

After RF treatments of 165, 175, 185, and 195 s, Salmonella spp. loads were reduced to 5.80 (SD ± 0.24), 4.00 (SD ± 0.27), 1.42 (SD ± 2.01) log CFU/g with complete decontamination at 195 s.

At 165 and 175 s of RF treatments, the E. faecium loads were reduced to 7.50 (SD ± 0.14) and 6.39 (SD ± 0.31) log CFU/g with complete decontamination at 185 and 195 s.

There were no statistically significant changes in the iron, vitamin A, or amino acid responses; sodium levels increased, and potassium and calcium levels decreased due to increasing RF treatment duration.

Abstract. The objectives of this research were: 1) to investigate the efficacy of RF heating on the decontamination of Salmonella enterica and Enterococcus faecium NRRL B-2354 in timothy hay; 2) to evaluate the suitability of E. faecium as a surrogate of Salmonella in timothy hay during RF treatment; 3) to assess the physicochemical changes after RF treatment on vitamins, amino acids, fatty acids, and trace minerals in the timothy hay. A pilot-scale parallel-plate RF heating system (6 kW, 27.12 MHz) was used to conduct this study. The electrode gap in the RF system was adjusted to 205 mm. Timothy hay was procured from a pet food manufacturing plant in Lincoln, Nebraska, at an initial moisture content (MC) of 7% to 9% (wet basis). Timothy hay samples (150 g) were inoculated with either a cocktail containing five serotypes of Salmonella enterica [Salmonella Agona (447967), Salmonella Mbandaka (698538), Salmonella Montevideo (488275), Salmonella Tennessee (K4643), and Salmonella Reading (Moff 180418)] or a broth of Enterococcus faecium then incubated at 37°C for 24 ± 2 h. Timothy hay samples were exposed to RF energy for 165, 175, 185, and 195 s. It was determined that after inoculation with the Salmonella cocktail and E. faecium, timothy hay samples had an initial microbial load of 7.81 and 7.75 log CFU/g, respectively. After RF treatments of 165, 175, 185, and 195 s, Salmonella loads (mean ± SD log CFU/g) were reduced to 5.80 ± 0.24, 4.00 ± 0.27, 1.42 ± 2.01 log CFU/g and below the level of detection, respectively. At 165 and 175 s of RF treatments, the E. faecium loads (mean ± SD log CFU/g) were reduced to 7.50 ± 0.14 and 6.39 ± 0.31 log CFU/g and below the detection level at 185 and 195 s. There was complete decontamination at 185 and 195 s. There were no statistically significant changes in the iron, vitamin A, or amino acid responses because of increasing RF treatment duration. The study demonstrated a non-chemical approach to decontaminating Salmonella and Enterococcus faecium from low-moisture foods such as pet foods. Keywords: Decontamination, Enterococcus faecium, Low moisture, Pet food, Radio-frequency, Salmonella, Timothy hay.
Efektifitas Nannochloropsis sp. terhadap sistem imun non-spesifik ikan mas Cyprinus carpio yang diinfeksi Virus Herpes
Authors: Lamadi Arafik 
Published: November 2023

The aim of this research was to determine the effect of Nannochlorpsisis sp. against the common carp (Cyprinus carpio) leukocyte profile, infected with Koi Hepesvirus (KHV). The descriptive observational method wa used in this study. This research was conducted for 4 weeks, using common carp length 12±0,3 cm as many as 7 fish. The tested experiment was P1: without infested by Nannochlorpsisis sp. and KH; P2: Infested by Nannochlorpsisis sp. and without KHV infected; P3: Infected by Nannochloropsis sp. and KHV; P4; Not infected by Nannochlorpsisis sp. and infected by KHV. Evey tratment in three replications. The results showed that the highest total leukocyte was obtained in P3 (37.600 cells/ml), followed by P4 (29.650 cells / ml), P2 (28,500 cells / ml) and P1 (21,150 cells / ml). Leukocyte differentiation test on P1 (neutrophil 6.2%, lymphocyte 68.0%, monocyte 17.0%), P2 (neutrophil 6.6%, lymphocyte 72.3%, monocyte 18.3%), P3 (neutrophil 7.9%, lymphocyte 66.1%, monocytes 24.3%), P4 (neutrophils 11.2%, lymphocytes 57.6%, monocytes 37.6%). The higher survivla rate was recorded in P2 (100%). It is concluded that Nannochloropsis sp. can enhance the common carp immune sytem.Penelitian ini bertujuan untuk mengetahui pengaruh pemberian Nannochlorpsis sp. terhadap profil leukosit ikan mas (Cyprinus carpio) yang terinfeksi Koi Herves Virus (KHV). Penelitian ini menggunakan metode deskriptif observasional dengan membandingkan hasil pada perlakuan 1) P1: (tanpa pemberian Nannochlorpsis sp. dan tidak diinfeksi KHV), 2) P2 (diberikan Nannochlorpsis sp dan tanpa diinfeksi KHV), 3) P3 (diberikan Nannochlorpsisis sp dan diinfeksi KHV), 4) P4 (tanpa pemberian Nannochlorpsis sp. dan diinfeksi KHV), masing-masing perlakukan 3 kali ulangan. Penelitian ini dilakukan selama 4 minggu dengan menggunakan Ikan mas berukuran 12±0,3 cm sebanyak 120 ekor. Hasil perhitungan total leukosit tertinggi diperoleh pada P3 (37.600 sel/ml), selanjutnya berturut-turut P4 (29.650 sel/ml), P2 (28.500 sel/ml) dan P1 (21.150 sel/ml). Hasil uji diferesnsiasi leukosit pada P1 (neutrofil 6.2%, limfosit 68.0%, monosit 17.0%), P2 (neutrofil 6.6%, limfosit 72.3%, monosit 18.3%), P3 (neutrofil 7.9%, limfosit 66.1%, monosit 24.3%), P4 (neutrofil 11.2%, limfosit 57.6%, monosit 37.6%). Kelangsungan hiudp tertinggi diperoleh pada perlakuan P2 (100%). Dapat disimpulkan bahwa Nannochloropsis sp. dapat digunakan untuk meningkatkan kekebalan tubuh ikan mas.
Performa pertumbuhan post-larva ikan jelawat (Leptobarbus hoevenii) pada berbagai kombinasi pakan alami dan buatan
Authors: Sunarno Mas T. D. , Syamsunarno Mas Bayu 
Published: November 2023

The study proposed to evaluate growth performance of post-larvae of jelawat (Leptobarbus hoevenii) fed on varius combination of natural food and artificial feed. Completely randomized design was assigned in this study. The treatments were various combinations of life feed of Moina sp. and artificial diet at a respective rates of 100:0%, 75:25%, 50:50%, 25:75% and 0:100%. The larvae of 20 days in age and 0.0287±0.0012 g in weight was randomly stocked in 15 buckets at a stocking rate of five larvae per liter or 50 larvae per bucket and fed on test diet at a feeding rate of 5% per body weight per day, divided in feeding frequency of five times for 45 days of rearing period. The results indicated that 20 days old of larvae jelawat fed on combinations of Moina sp. and artificial diet at 50:50 performed higher survival as well as growth.Tujuan penelitian adalah untuk mengevaluasi performa pertumbuhan post larvae jelawat (Leptobarbus hoevenii) pada berbagai kombinasi pakan alami dan pakan buatan. Rancangan Acak Lengkap digunakan dalam penelitian ini. Perlakuannya adalah berbagai kombinasi pakan alami Moina sp. dan pakan buatan, masing-masing yaitu 100:0%, 75:25%, 50:50%, 25:75% and 0:100%. Larva ikan jelawat umur 20 hari dengan bobot rata-rata 0,0287±0,0012 g ditebar secara acak ke dalam 15 buah ember dengan kepadatan 5 ekor per liter atau 50 ekor per wadah dan diberi pakan uji sebanyak 5% dari bobot tubuh per hari yang dibagi dalam lima kali pemberian selama 45 hari masa pemeliharaan. Hasil penelitian menunjukkan bahwa larva ikan jelawat umur 20 hari mempunyai kelangsungan hidup dan pertumbuhan lebih baik dengan pemberian kombinasi pakan alami Moina sp.. dan pakan buatan sebesar 50% : 50%.
Real life condition evaluation of Inoserp PAN-AFRICA antivenom effectiveness in Cameroon
Authors: Chippaux Jean-Philippe , Ntone Rodrigue , Benhammou David , Madec Yoann , Noël Gaëlle , Perilhou Anais , Karl Fai , Amta Pierre , Sanchez Marie , Matchim Lucrece , Clauteaux Pedro , Eteki Lucrèce , Ndifon Mark , Boum Yap , Nkwescheu Armand S. , Taieb Fabien 
Published: November 2023

Background
Snakebites is a serious public health issue but remains a neglected tropical disease. Data on antivenom effectiveness are urgently needed in Africa. We assessed effectiveness of Inoserp PAN-AFRICA (IPA), the recommended antivenom available in Cameroon.

Methodology/Principal findings
We enrolled 447 patients presenting with snakebite in 14 health facilities across Cameroon. At presentation, cytotoxicity, coagulation troubles and neurotoxicity were graded. We administered two to four vials of antivenom to patients based on hemotoxic or neurotoxic signs. We renewed antivenom administration to patients with persistence of bleedings or neurotoxicity 2 hours after each injection. We defined early improvement as a reduction of the grade of envenomation symptoms 2 hours after first injection. Medium-term effectiveness was investigated looking at disappearance of symptoms during hospitalization. After hospital discharge, a home visit was planned to assess long-term outcomes.
Between October 2019 and May 2021, we enrolled 447 (93.7%), including 72% from the savannah regions. The median [IQR] age was 25 [14–40]. Envenomation was diagnosed in 369 (82.6%) participants. The antivenom was administered to 356 patients (96.5%) of whom 256 (71.9%) received one administration. Among these patients, cytotoxic symptoms were observed in 336 (94.4%) participants, coagulation disorders in 234 (65.7%) participants and neurotoxicity in 23 (6.5%) participants. Two hours after the first administration of antivenom, we observed a decrease in coagulation disorders or neurotoxicity in 75.2% and 39.1% of patients, respectively. Complete cessation of bleedings and neurotoxicity occurred in 96% and 93% of patients within 24 hours, respectively. Sequelae have been observed in 9 (3%) patients at the home visit 15 days after hospital admission and 11 (3%) died including one before antivenom injection.

Conclusions/Significance
We confirmed good effectiveness of the IPA and highlighted the rapid improvement in bleeding or neurotoxicity after the first administration. Sequential administrations of low doses of antivenom, rigorously assessed at short intervals for an eventual renewal, can preserve patient safety and save antivenom.

Trial registration
NCT03326492.
Clinical evaluation of the alcohol use disorders identification test (AUDIT) in Moshi, Tanzania
Authors: Vissoci Joao Ricardo Nickenig , Friedman Kaitlyn , Caruzzo Nayara Malheiros , de Oliveira Leonardo Pestillo , Pauley Alena , Zadey Siddhesh , Menegassi Vanessa , Sakita Francis , Boshe Judith , Staton Catherine A. , Mmbaga Blandina 
Published: November 2023

Background
Alcohol use disorder is a major cause of morbidity and mortality in low- and middle-income countries. Alcohol screening using a validated tool is a useful way to capture high-risk patients and engage them in early harm reduction interventions. Our objectives were to 1) evaluate the psychometric evidence the Alcohol Use Disorders Identification Test (AUDIT) and its subscales in the general population of Moshi, Tanzania, and 2) evaluate the usefulness of the tool at predicting alcohol-related harms.

Methods
Two hundred and fifty-nine adults living in Moshi, Tanzania were included in the study. We used the AUDIT and its subscales to determine the classification of harmful and hazardous drinking. To analyze the internal structure of AUDIT and the model adequacy we used Confirmatory Factor Analysis (CFA). The reliability of AUDIT was analyzed for Cronbach’s alpha, Omega 6 and Composite Reliability. The optimal cut off point for the AUDIT was determined by the receiver operating characteristic (ROC) curve, using the Youden approach to maximize sensitivity and specificity.

Results
The median score of the AUDIT was 1 (inter-quartile range: 0–7). The internal structure of the AUDIT showed factor loadings ranging from 0.420 to 0.873. Cronbach’s alpha, Omega and Composite Reliability produced values above 0.70. The Average Variance Extracted was 0.530. For the AUDIT, a score of 8 was identified as the ideal cut-off value in our population.

Conclusions
This study validates AUDIT in the general population of Moshi and is one of the only studies in Africa to include measures of the internal structure of the AUDIT and its subscales.
Risk of Coronavirus Disease 2019 (COVID-19) among those up-to-date and not up-to-date on COVID-19 vaccination by US CDC criteria
Authors: Shrestha Nabin K. , Burke Patrick C. , Nowacki Amy S. , Gordon Steven M. 
Published: November 2023

Background
The CDC recently defined being “up-to-date” on COVID-19 vaccination as having received at least one dose of a COVID-19 bivalent vaccine. The purpose of this study was to compare the risk of COVID-19 among those “up-to-date” and “not up-to-date”.

Methods
Employees of Cleveland Clinic in Ohio, USA, in employment when the COVID-19 bivalent vaccine first became available, and still employed when the XBB lineages became dominant, were included. Cumulative incidence of COVID-19 since the XBB lineages became dominant was compared across the”up-to-date” and “not up-to-date” states, by treating COVID-19 bivalent vaccination as a time-dependent covariate whose value changed on receipt of the vaccine. Risk of COVID-19 by vaccination status was also evaluated using multivariable Cox proportional hazards regression adjusting for propensity to get tested for COVID-19, age, sex, most recent prior SARS-CoV-2 infection, and number of prior vaccine doses.

Results
COVID-19 occurred in 1475 (3%) of 48 344 employees during the 100-day study period. The cumulative incidence of COVID-19 was lower in the “not up-to-date” than the “up-to-date” state. On multivariable analysis, being “up-to-date” was not associated with lower risk of COVID-19 (HR, 1.05; 95% C.I., 0.88–1.25; P-value, 0.58). Results were very similar when those 65 years and older were only considered “up-to-date” after 2 doses of the bivalent vaccine.

Conclusions
Since the XBB lineages became dominant, adults “up-to-date” on COVID-19 vaccination by the CDC definition do not have a lower risk of COVID-19 than those “not up-to-date”, bringing into question the value of this risk classification definition.