bluuebunny/crossref_metadata_2025_split huggingface dataset:
Intersectional Repertoires of Coping with Political Violence
Authors: Mügge Liza , Özvatan Özgür 
Published: January 2025

Abstract
Violence against elected representatives—be it physical or psychological, online or offline, threatened or realized—undermines democracy. This is particularly the case when violence targets politicians from historically underrepresented groups, whose members may choose not to run for office, self-censor, or drop out. Based on interviews with twenty-three former and current members of the German Bundestag with a migration background, our exploratory study examines their strategies to cope with violence and the intersectional mechanisms underpinning their repertoires. MPs’ strategies to both prevent and respond to violence drew on a combination of individual resources and those provided by their private, collective, professional, and institutional environments; their use of specific strategies and access to resources had clear intersectional patterns. Racialized female MPs who had to expend the most time and energy coping with violence that attacked their very presence in politics had the least resources at their disposal.
European labour law as part of an economic union, monetary union and community of values—between harmonization and subsidiarity
Authors: Schubert Claudia 
Published: January 2025

Abstract
The development of European labour law was neither straightforward nor continuous but followed the development of the European single market for a long time. Today, European labour law is an essential part of the social market economy in the European Union, even if there is no uniform European social model. The European Pillar of Social Rights is a commitment to a social Europe and accelerated regulatory practice. From a political science perspective, the development of European labour law was and is dependent on the legitimacy of its actions of the European Union. Therefore, unlike in nation-states, no clearly defined concept of (European) labour law has emerged. Rather, three central areas can be identified: (1) transnational labour law, primarily the free movement of workers, as nucleus of European labour law, (2) European labour law as a result of the interference of business-related fundamental freedoms with the welfare states in the Member States, and (3) European labour law as a result of a proactive social policy. However, the European Union has and will have to continue to organise its legislation in coordination with the welfare states in the Member States. Politically, it must prove that its measures are necessary because it can regulate the issues in question better than the Member States would be able to. Crises affecting several Member States are often the main driving force behind the deepening of the cooperation in the field of social policy. In addition, new developments can give the Member States reasons to take a standardised approach from the outset. Furthermore, the European Union should act primarily in connection with such social standards regarding which all Member States have already ratified international conventions without reservations and have thus agreed on a uniform standard.
Brain‐derived neurotrophic factor drives muscle adaptation similar to aerobic training in mice
Authors: Brown Alexander D. , Marko Alexander D. , Marko Daniel M. , Baranowski Bradley J. , Silvera Sebastian , Finch Michael S. , Yang Alex J. , Dhaliwal Roopan , Ryan Chantal R. , Roy Brian D. , Fajardo Val A. , MacPherson Rebecca E. K. 
Published: January 2025

AbstractThis study, in vivo and in vitro, investigated the role of brain‐derived neurotrophic factor (BDNF) in skeletal muscle adaptations to aerobic exercise. BDNF is a contraction‐induced protein that may play a role in muscle adaptations to aerobic exercise. BDNF is involved in muscle repair, increased fat oxidation, and mitochondrial biogenesis, all of which are adaptations observed with aerobic training. The purpose of this study was two‐pronged and investigated the skeletal muscle BDNF response to (1) acute and (2) chronic exercise in male C57BL/6J mice. It also examined if chronic BDNF treatment resulted in similar adaptations to chronic exercise. In aim 1, mice underwent a 2 hr. treadmill exercise bout. In aim 2, mice were assigned to one of four groups: (1) control (CON); (2) endurance training (ET; treadmill running 1 h/day, 5 days/wk); (3) BDNF (BDNF; 0.5 mg/kg·bw, 5 days/wk); (4) endurance training and BDNF (ET + BDNF) for 8 weeks. Results demonstrated that the soleus (SOL) had higher BDNF content compared with the extensor digitorum longus (EDL) and that SOL BDNF increased with acute exercise. After chronic exercise and BDNF treatment, treadmill testing to exhaustion demonstrated a main effect of BDNF and ET on increasing exercise capacity. In vitro contractile assessment of the EDL revealed BDNF treatment resulted in similar increases in the max rate of relaxation as ET. EDL force‐frequency analysis showed ET + BDNF produced higher force than CON and BDNF, indicating an additive effect. BDNF increased EDL mitochondrial proteins, COXIV, and CS. These results demonstrate that BDNF contributes to muscle adaptations observed with ET.
AGDMP1 alleviates insulin resistance by modulating heat shock protein 60‐mediated IRS‐1/AKT/GLUT4 pathway and adipose inflammation: A potential therapeutic peptide for gestational diabetes mellitus
Authors: Wang Shanshan , Zhang Yuting , Hu Shiman , Bai Xueqi , Zhu Jiamin , Hao Runrun , Cao Yan , Shi Zhonghua 
Published: January 2025

AbstractGestational Diabetes Mellitus (GDM) is the most frequent complication during pregnancy. Pharmacological interventions, such as peptide drugs that focused on improving the insulin sensitivity might be promising in the prevention and treatment of GDM. In this study, we aimed to investigate the role and mechanism of a novel peptide, named AGDMP1 (Anti‐GDM peptide 1), which we previously identified lower in the serum of GDM patients using mass spectrometry, on the adipose insulin resistance in GDM. We found that AGDMP1 had a high affinity for adipose tissues in vivo. AGDMP1 markedly improved glucose homeostasis and insulin resistance in GDM mice. This was associated with reduced inflammation and upregulated AKT/GLUT4 signaling pathway in white adipose tissue. In vitro, AGDMP1 could increase glucose uptake and insulin sensitivity of adipocytes by activating the IRS‐1/AKT/GLUT4 signaling pathway under basal, insulin‐stimulated, and insulin‐resistant conditions, respectively. Mechanistically, we found that AGDMP1 could bind to HSP60 to dampen its effects on AKT signaling and pro‐inflammatory response, which was reversed in the present of recombinant HSP60 protein. AGDMP1 ameliorated adipose insulin resistance and inflammation by targeting HSP60 and activating the IRS‐1/AKT/GLUT4 signaling pathway. These data supported AGDMP1 with therapeutic potential in GDM and associated pathologies.
Nursing Student and Faculty Attitudes, Perceptions, and Behavioral Intentions of Artificial Intelligence Use in Nursing Education
Authors: Ostick Mollie , Mariani Bette , Lovecchio Catherine , Moriarty Helene 
Published: January 2025

Abstract

AIM
This integrative review critiques and synthesizes current research on nursing faculty and students’ attitudes, perceptions, and behavioral intentions toward artificial intelligence (AI)-based tools in nursing education.

BACKGROUND
AI’s rapid integration into health care offers transformative potential in nursing across clinical care, education, policy, and research.

METHOD
Following Whittemore and Knafl’s methodology, Pubmed, CINAHL, and ERIC were searched for studies written in English assessing attitudes, perceptions, and behavioral intentions of nursing students and faculty regarding AI use in nursing education.

RESULTS
Six quantitative studies encompassing 2,430 participants across five countries were included. They revealed generally positive attitudes toward the use of AI in nursing education. Only one study included faculty.

CONCLUSION
A logical next step is to compare and contrast student and faculty perceptions of using AI. Generative AI tools must be studied within nursing education to allow for informed integration and the development of appropriate training programs.
Refractive accuracy of the new Barrett formula using segmented axial length compared with that of the traditional Barrett Universal II formula
Authors: Hata Seiichiro , Kobayashi Manabu 
Published: January 2025

Purpose:
To compare the refractive accuracy of the Barrett True axial length (BTAL) formula, newly integrated into ARGOS, with that of the Barrett Universal II (BUII) formula calculated using axial length (AL) from IOL Master 700.

Setting:
Private clinics in Kanagawa, Japan.

Design:
Retrospective observational study.

Methods:
We assessed eyes of patients who underwent cataract surgery with SY60WF IOL implantation, using ARGOS and IOL Master 700. The predicted refraction for BTAL was back-calculated. Refractive prediction errors (RPEs) for BTAL, BUII with ARGOS (segmented BUII), and BUII with IOL Master 700 (composite BUII) were compared. We primarily aimed to demonstrate the non-inferiority of BTAL to composite BUII in absolute RPE.

Results:
We included 209 eyes from 209 patients. BTAL met the non-inferiority criteria, as the upper confidence interval (CI) boundary was below the non-inferiority margin of 0.10 diopters (D) for the difference in absolute RPE (−0.03 D; 95% CI: −0.06 to 0.01). In short eyes (AL ≤ 22.5 mm), the median absolute RPEs for BTAL, segmented BUII, and composite BUII were 0.25, 0.18, and 0.37 D, respectively, with significant differences between BTAL and composite BUII (p = 0.028) and segmented BUII and composite BUII (p = 0.018). In long eyes (AL > 26 mm), the median absolute RPEs were 0.21, 0.20, and 0.28 D for BTAL, segmented BUII, and composite BUII, respectively.

Conclusions:
BTAL was non-inferior to composite BUII in absolute RPE. BTAL is an accurate and useful intraocular lens power calculation formula, even in eyes with short and long AL.
The effect of dynamic neuromuscular stabilization technique combined with Kinesio Taping on neuromuscular function and pain self-efficacy in individuals with chronic nonspecific low back pain: A randomized trial
Authors: Hei Peng , Zhang Zhe , Wei Jiaxin , Lan Chaoyu , Wang Xinyu , Jing Xiongxiong , Chen Xuexue , Wu Zhigang 
Published: January 2025

Background:
This study investigates the therapeutic efficacy of dynamic neuromuscular stabilization (DNS) technology paired with Kinesio Taping in patients with persistent nonspecific low back pain, as well as the effect on neuromuscular function and pain self-efficacy.

Methods:
A randomized controlled clinical study was conducted to collect clinical data on DNS combined with KT for the treatment of chronic nonspecific low back pain from November 2023 to April 2024. The inclusion criteria were patients with chronic nonspecific lower back pain, aged between 18 and 30 years old, and without serious underlying medical conditions, such as cardiac disease, hypertension, and diabetes. The control group received Kinesio Tape therapy, and the experimental group received a combination of Kinesio Tape therapy and DNS technology. The treatment lasted for 6 weeks, 3 times a week. Patients were examined before and after treatment using the Visual Analog Rating Scale, Oswestry Dysfunction Score, and Pain Self-Efficacy Questionnaire. Multifidus and transversus abdominis muscle strength was tested using surface electromyography signals, and the patient’s joint mobility, maximal isometric muscle strength, and muscular endurance were tested using the Davy Spine Rehabilitation System. Internal lumbar and abdominal pressures were assessed using stabilizer pressure biofeedback.

Results:
A total of 32 subjects (17 males and 15 females) were enrolled, of which 16 were in the experimental group and 16 in the control group. After the treatment, the patients in both groups showed significant improvements in the visual analogue scale, Oswestry disability index, Chinese version of Pain Self-Efficacy Questionnaire (PSEQ), joint mobility, maximum isometric strength, muscle endurance, abdominal pressure, transverse abdominal muscle and multifidus muscle scales compared with the pretreatment results. (Chinese version of Pain Self-Efficacy Questionnaire) scales were significantly improved compared with the pretreatment; joint mobility, maximal isometric muscle strength, muscular endurance, intra-abdominal pressure, transversus abdominis and multifidus AEMG (average electromyography) were more significantly improved, and the differences were statistically significant (P < .05). The experimental group showed more significant improvement than the control group (P < .05).

Conclusion:
DNS technology paired with Kinesio Taping can considerably improve neuromuscular function and enhance pain self-efficacy in chronic nonspecific low back pain patients, reducing discomfort and improving dysfunction.
Factors associated with higher caregiver burden among informal caregivers of Parkinson’s disease: A systematic review
Authors: Wu Jinwen , Liu Mengnan , Chen Mingtai , Xue Jinyi , Zou Yuan , Deng Ziwen , Zhao Shufei , Yang Xue 
Published: January 2025

Background:
Parkinson’s disease is a progressive neurodegenerative disease and the care burden in informal caregivers is huge. Summarizing factors associated with the informal caregivers burden can improve our understanding of providing proactive support to informal caregivers caring for patients with Parkinson’s disease (PwP) at risk, and provides evidence for clinical practice.

Methods:
PRISMA guidelines were followed in this systematic review. We searched 9 databases in May 2024 for studies reporting data on factors associated with the care burden of informal caregivers for PwP.

Results:
We identified 16456 records of which 28 met inclusion criteria. Informal caregivers from 12 countries were included. There were 38 factors shown to be linked to higher care burden. The evidence indicated that informal caregivers who were depressed, caring for PwP with lower quality of life, caring for PwP with lower ADL scores, or caring for PwP with depression reported high care burden.

Conclusion:
Targeted interventions addressing those modifiable factors should be developed and investigated to lighten the care burden of informal caregivers for PwP.
Right coronary sinus of Valsalva pseudoaneurysm after a motorcycle accident: A case report
Authors: Cheng Yong , Zhang Yu , Liu Zixuan , Wang Ziwei , Shuai Tao 
Published: January 2025

Rationale:
Traumatic pseudoaneurysm of the sinus of Valsalva (PSV) is a rare but life-threatening condition, often resulting from blunt chest trauma. Rapid progress and a high risk of rupture highlight the importance of prompt diagnosis and intervention. We present a case of a rare pseudoaneurysm linked to the right coronary sinus after blunt chest trauma.

Patient concerns:
A 54-year-old male presented with chest pain, loss of consciousness, and coma following a motorcycle accident. Initial management included invasive ventilation at a local hospital before transfer for specialized care.

Diagnoses:
Computed tomography angiography and transthoracic echocardiography confirmed a blunt traumatic PSV, along with an 8th rib fracture, findings later corroborated during open thoracotomy.

Interventions:
The pseudoaneurysm was surgically treated with an open thoracotomy, and the defect was sealed using a pericardial patch.

Outcomes:
The patient experienced an uneventful recovery, with follow-up confirming the restoration of normal daily activities.

Lessons:
Traumatic PSV, though rare, demands heightened clinical awareness in cases of blunt chest trauma. Noninvasive computed tomography angiography serves as a rapid and reliable diagnostic tool. Early surgical intervention remains the definitive treatment to prevent catastrophic outcomes.
Efficacy of wound care ointment in healing infectious wounds after anorectal surgery: A randomized controlled trial
Authors: Yu Lelai , Lei Yinfu , Yuan Ke 
Published: January 2025

Background:
This study evaluates the efficacy of a novel bismuth subgallate-borneol compound ointment as an adjuvant therapy in promoting postoperative healing of infectious incisions after anorectal surgery.

Methods:
From June 2023 to October 2023, 46 patients with perianal abscess and anal fistula treated at our institution’s Anorectal Surgery Department were enrolled in this prospective randomized controlled study. Patients were randomly allocated into 2 groups: the experimental group (n = 23) received conventional wound care plus a proprietary ointment containing 4.5% bismuth subgallate and 0.7% d-borneol in a Vaseline base, while the control group (n = 23 cases) received conventional wound care alone (comprising daily wound cleansing, dressing changes and traditional Chinese medicine injection). Image J Software was used for collecting the data of wound area, and the wound healing rate and granulation growth rate of the 2 groups were calculated to evaluate the therapeutic effect of the 2 groups.

Results:
The growth rate of cured granulation in the experimental group was higher than that in the control group at all 3 predetermined observation points, with statistically significant difference (P < .05). Furthermore, the wound healing rate of the experimental group showed significant improvement by day 14 (P < .05).

Conclusion:
The bismuth subgallate-borneol compound ointment, when used as an adjuvant to standard wound care protocols, demonstrates significant efficacy in treating post-anorectal surgery infectious wounds. Its dual-active component formulation appears to effectively promote both granulation tissue formation and wound healing, potentially through its documented antibacterial properties.
Gated myocardial perfusion SPECT for evaluating left ventricular dyssynchrony in cardiac resynchronization therapy candidates: a systematic review
Authors: Stępień-Wroniecka Agnieszka , Dziewięcka Ewa , Graczyk Katarzyna , Holcman Katarzyna , Winiarczyk Mateusz , Przytuła Natalia , Kostkiewicz Magdalena , Podolec Piotr , Rubiś Paweł 
Published: January 2025

Objectives
Cardiac resynchronization therapy (CRT) is an intervention for heart failure patients with reduced ejection fraction who exhibit specific electrocardiographic indicators of electrical dyssynchrony. However, electrical dyssynchrony does not universally correspond to left ventricular mechanical dyssynchrony (LVMD). Gated single-photon emission computed tomography (SPECT) myocardial perfusion allows for the assessment of LVMD, yet its role in the CRT selection process remains debated.

Methods
We conducted a systematic literature review to critically evaluate the evidence for the prediction and prognostic utility of SPECT for LVMD in assessing LVMD among CRT candidates. The review adhered to PRISMA 2020 Statement criteria and included articles from PubMed, Embase, and Cochrane databases. The quality of evidence was appraised using the Grading of Recommendations, Assessment, Development, and Evaluation framework.

Results
From an initial pool of 1055 records, 33 met the inclusion criteria and provided original data on the predictive value of myocardial perfusion SPECT for LVMD. Most of them measured LVMD according to established recommendations, focusing on phase histogram bandwidth (HBW) and phase histogram standard deviation (PSD). Out of 2066 patients from 27 studies, 62% (n = 1214) were qualified as CRT responders. Five studies reported SPECT-based cutoffs for predicting CRT response (HBW ranging 55°–152° and for PSD 20°–54°). Only five studies assessed the prognostic implications of baseline SPECT-measured LVMD, indicating that elevated baseline HBW and PSD values are associated with poorer outcomes.

Conclusion
The objective and reproducible measurement of LVMD provided by SPECT underscores its potential as a valuable tool. Such assessment seems to be emerging as a promising adjunctive technique with potential to enhance CRT outcomes.
Preoperative Anemia as a Prognostic Risk Factor for Inferior Oncological Survival Following Resection for Pancreatic Ductal Adenocarcinoma
Authors: Bos Mylena D. , Meyer N. Helge , Wijma Allard G. , Khatib-Chahidi Karl , van den Broek Evert , Ho Cassandra S.L. , Meerdink Mark , Klaase Joost M. , Bockhorn Maximilian , Hoogwater Frederik J.H. , Nijkamp Maarten W. 
Published: January 2025

Objectives:
A significant proportion of patients undergoing surgery for pancreatic ductal adenocarcinoma (PDAC) are anemic at the time of resection. In these patients, blood transfusions are omitted due to their potential negative impact on oncological outcomes. The aim of the present study was to determine the prognostic value of preoperative anemia in resected PDAC patients, irrespective of blood transfusion status.

Methods:
In this retrospective two-center cohort study patients who underwent resection for histologically confirmed PDAC between 2013 and 2022 were included. The prognostic role of preoperative anemia was investigated using Cox proportional-hazard regression analysis. A subgroup analysis was performed in which PDAC patients who received a perioperative blood transfusion were excluded.

Results:
Among the 280 PDAC patients who were included, 110 (39%) were found to have anemia prior to surgery. Preoperative anemia was associated with increased use of blood transfusions, with a total of 44 patients (16%) requiring transfusion perioperatively. In the whole cohort, preoperative anemia was found to be an independent predictor of lower disease-free survival (DFS) (HR=1.518; 95% CI 1.103-2.090; P=0.011), but not overall survival (OS). However, when patients who received a perioperative blood transfusion were excluded from the analysis, preoperative anemia was independently associated with both lower DFS (HR=1.636; 95% CI 1.113-2.404; P=0.012) and OS (HR=1.484; 95% CI 1.036-2.127; P=0.031).

Conclusions:
Preoperative anemia was shown to be an independent risk factor for inferior oncological survival after resection for PDAC. These results support the need for increased awareness regarding the potential adverse effects of preoperative anemia on oncological outcomes in PDAC.
68Ga-FAPI-04 Outperforms 18F-FDG in Detecting Lesions for Primary Leiomyosarcoma of Bone
Authors: Jiang Yaqun , Tian Yueli , He Yong 
Published: January 2025

Abstract
Primary leiomyosarcoma of bone (PLB) is an ultrarare tumor, characterized by its aggressive clinical behavior, high heterogeneity, and dismal prognosis. Here, we present the 68Ga-FAPI-04 and 18F-FDG PET/CT findings in a case of PLB affecting the left femur. FAPI PET/CT showed more bone lesions and higher uptake in the multiple metastatic lesions compared with FDG PET/CT. More interestingly, FAPI PET/CT could clearly detect the tumor embolus on the left common femoral artery, which was negative on FDG. This case suggests that FAPI PET/CT is a promising method for the primary diagnosis and staging of PLB.
Diffuse Large B-Cell Lymphoma With the “Leopard Man” Appearance on 18F-FDG PET/CT
Authors: Wang Kangkang , Huang Hao 
Published: January 2025

Abstract
Subcutaneous nodules and masses as the primary manifestation of diffuse large B-cell lymphoma are exceedingly rare. We present 18F-FDG PET/CT findings of multiple hypermetabolic nodules and masses distributed throughout the body, creating a characteristic “leopard man” appearance on the MIP image, in a 65-year-old man. An excisional biopsy of the right thigh mass confirmed the diagnosis of diffuse large B-cell lymphoma.