bluuebunny/crossref_metadata_2025_split huggingface dataset:
The influence of upright posture on craniospinal, arteriovenous, and abdominal pressures in a chronic ovine in-vivo trial
Authors: Podgoršak Anthony , Trimmel Nina Eva , Oertel Markus Florian , Arras Margarete , Weisskopf Miriam , Schmid Daners Marianne 
Published: November 2023

Abstract
Introduction
Most investigations into postural influences on craniospinal and adjacent physiology have been performed in anesthetized animals. A comprehensive study evaluating these physiologies while awake has yet been completed.

Methods
Six awake sheep had telemetric pressure sensors (100 Hz) implanted to measure intracranial, intrathecal, arterial, central venous, cranial, caudal, dorsal, and ventral intra-abdominal pressure (ICP, ITP, ABP, CVP, IAPcr, IAPcd, IAPds, IAPve, respectively). They were maneuvered upright by placing in a chair for two minutes; repeated 25 times over one month. Changes in mean and pulse pressure were calculated by comparing pre-chair, P0, with three phases during the maneuver: P1, chair entrance; P2, chair halftime; P3, prior to chair exit. Statistical significance (p ≤ .05) was assessed using repeated measures ANOVA.

Results
Significant mean pressure changes of (P1 − P0) and (P3 − P0) were measured at − 12.1 ± 3.1 and − 14.2 ± 3.0(p < .001), 40.8 ± 10.5 and 37.7 ± 3.5(p = .019), 9.7 ± 8.3 and 6.2 ± 5.3(p = .012), 22.3 ± 29.8 and 12.5 ± 12.1(p = .042), and 11.7 ± 3.9 and 9.0 ± 5.2(p = .014) mmHg, for ICP, ITP, IAPds, IAPcr, IAPca, respectively. For pulse pressures, significant changes of (P1 − P0) and (P3 − P0) were measured at − 1.3 ± 0.7 and − 2.0 ± 1.1(p < .001), 4.7 ± 2.3 and 1.4 ± 1.4(p < .001), 15.0 ± 10.2 and 7.3 ± 5.5(p < .001), − 0.7 ± 1.8 and − 1.7 ± 1.7(p < .001), − 1.3 ± 4.2 and − 1.4 ± 4.7(p = .006), and 0.3 ± 3.9 and − 1.0 ± 1.3(p < .001) mmHg, for ICP, ITP, ABP, IAPds, IAPcr, IAPca, respectively.

Conclusions
Pressures changed posture-dependently to differing extents. Changes were most pronounced immediately after entering upright posture (P1) and became less prominent over the chair duration (P2-to-P3), suggesting increased physiologic compensation. Dynamic changes in IAP varied across abdominal locations, motivating the abdominal cavity not to be considered as a unified entity, but sub-compartments with individual dynamics.
Correlation between gut microbiota composition, enteric infections and linear growth impairment: a case–control study in childhood stunting in Pidie, Aceh, Indonesia
Authors: Rinanda Tristia , Riani Catur , Artarini Anita , Sasongko Lucy 
Published: November 2023

Abstract
Background
Gut microbiota is pivotal in maintaining children's health and well-being. The ingestion of enteric pathogens and dysbiosis lead to Environmental Enteric Dysfunction (EED), which is essential in stunting pathogenesis. The roles of gut microbiome and enteric infections have not been explored comprehensively in relation to childhood stunting in Indonesia. This study aimed to determine the correlation between gut microbiota composition, enteric infections, and growth biomarker, Insulin-like Growth Factor 1 (IGF-1), in stunted children from Pidie, Aceh, Indonesia.

Methods
This study was a case–control study involving 42 subjects aged 24 to 59 months, comprising 21 stunted children for the case and 21 normal children for the control group. The IGF-1 serum level was quantified using ELISA. The gut microbiome profiling was conducted using 16S rDNA amplicon sequencing. The expression of enteric pathogens virulence genes was determined using quantitative PCR (qPCR) assay. The correlations of observed variables were analysed using suitable statistical analyses.

Results
The result showed that the IGF-1 sera levels in stunted were lower than those in normal children (p ≤ 0.001). The abundance of Firmicutes (50%) was higher than Bacteroidetes (34%) in stunted children. The gut microbiome profile of stunted children showed enriched genera such as Blautia, Dorea, Collinsella, Streptococcus, Clostridium sensu stricto 13, Asteroleplasma and Anaerostipes. Meanwhile the depleted genera comprised Prevotella, Lactococcus, Butyrivibrio, Muribaculaceae, Alloprevotella, Akkermansia, Enterococcus, Terrisporobacter and Turicibacter. The abundance of water biological contaminants such as Aeromonas, Stappiaceae, and Synechococcus was also higher in stunted children compared to normal children. The virulence genes expression of Enteroaggregative Escherichia coli (aaiC), Enterotoxigenic E. coli (estA), Enteropathogenic E. coli (eaeA), Shigella/Enteroinvasive E. coli (ipaH3) and Salmonella enterica (ompC) in stunted was higher than in normal children (p ≤ 0.001), which negatively correlated to height and level of IGF-1.

Conclusion
The present study showed the distinctive gut microbiome profile of stunted and normal children from Pidie, Aceh, Indonesia. The gut microbiota of stunted children revealed dysbiosis, comprised several pro-inflammatory, metabolic abnormalities and high-fat/low-fiber diet-related taxa, and expressed virulence genes of enteric pathogens. These findings provide evidence that it is imperative to restore dysbiosis and preserve the balance of gut microbiota to support linear growth in children.
The association between pro-vegetarian dietary pattern and risk of colorectal cancer: a matched case-control study
Authors: Nejad Elham Tavassoli , Moslemi Elham , Souni Fateme , Mahmoodi Marzieh , Vali Mohebat , Vatanpour Mohammad , Nouri Mehran , Ramezani Atena , Shateri Zainab , Rashidkhani Bahram 
Published: November 2023

Abstract
Background
Few studies assess the link between plant-based diets and colorectal cancer (CRC) incidence. To our knowledge, no study has examined the association between pro-vegetarian dietary pattern (PDP) and CRC globally or among Iranians. Therefore, the objective of our matched case-control study was to evaluate the association between PDP and CRC in the Iranian population.

Methods
The present research was a hospital-based case (n = 71)-control (n = 142) study conducted in the same hospitals in Tehran, Iran. This study used a reliable and valid semi-quantitative food frequency questionnaire to evaluate the participants’ dietary intake. According to the residual method, the selected plant and animal foods have been adjusted in the total energy intake to calculate the PDP index. Odds ratios (ORs) and 95% confidence intervals (CIs) adjusted for confounding variables were also expressed using logistic regression by SPSS software.

Results
In the crude and adjusted models, we observed that the odds of CRC decreased significantly in the 3rd and last quartile of PDP compared to the 1st quartile (Q) (Crude model: Q3: OR = 0.36, 95% CI: 0.17 − 0.79, P-value = 0.011 and Q4: OR = 0.33, 95% CI: 0.14 − 0.79, P-value = 0.012 - Adjusted model: Q3: OR = 0.41, 95% CI: 0.18 − 0.94, P-value = 0.035 and Q4: OR = 0.35, 95% CI: 0.14 − 0.87, P-value = 0.025).

Conclusions
Based on the results of the present case-control study in the Iranian population, it was concluded that PDP, which involves consuming vegetables, fruits, cereals, dairy products, and low meat consumption, reduces the odds of CRC. In conclusion, adherence to PDP is associated with a decreased odds of CRC.
Anti-Cryptosporidium oocysts polyclonal antibodies for cryptosporidiosis diagnosis and protection
Authors: Farid Alyaa , Aiad Silvia , Safwat Gehan 
Published: November 2023

AbstractCryptosporidiosis is an intestinal infection that is triggered by the protozoan parasiteCryptosporidiumspp.Cryptosporidiumoocysts can spread from one host to another either through direct contact with infected hosts' faeces or through indirect means (consumption of contaminated water or food). Significant numbers of oocysts are produced as a result of the rapid growth of the parasite within the infected hosts. For proper care of cryptosporidiosis, a laboratory diagnosis is necessary. Therefore, this study aimed to produce anti-Cryptosporidium parvum(C. parvum) oocyst immunoglobulin (Ig)G polyclonal antibodies (pAbs). The produced pAbs were used in the detection ofC. parvumoocysts antigens in stool and serum samples of infected calves. Moreover, pAbs were tested in protection of balb-c male mice from cryptosporidiosis infection.C. parvumoocysts were used in the preparation of antigens to be used in the immunization of New Zealand white rabbits. pAb was purified by ammonium sulphate precipitation method, caprylic acid purification method and diethylaminoethyl (DEAE) anion exchange chromatographic method. Sandwich enzyme-linked immunosorbent assay (ELISA) (using prepared pAb) scored higher sensitivity (85% and 95% for serum and stool samples) than that (80%) of microscopic examination of stool samples. Moreover, pAb significantly reduced the oocysts shedding, decreased inflammatory cytokines and enhanced the loss in the body weight of protected animals. The prepared pAb succeeded in the diagnosis of cryptosporidiosis in calves with high sensitivity either in the serum or stool samples. Our results indicated the usefulness of using the prepared pAb in protection against cryptosporidiosis.
Extracorporeal adsorption of protective and toxic bile acids and bilirubin in patients with cholestatic liver dysfunction: a prospective study
Authors: Greimel Antonia , Habler Katharina , Gräfe Caroline , Maciuga Nils , Brozat Clara Isabell , Vogeser Michael , Zoller Michael , Happich Felix L. , Liebchen Uwe , Frank Sandra , Paal Michael , Scharf Christina 
Published: November 2023

Abstract
Background
The release of toxic bile acids (BAs) in the blood of critically ill patients with cholestatic liver dysfunction might lead to the damage of various organs. Their extracorporeal elimination using the cytokine adsorber Cytosorb® (CS) (adsorption of especially hydrophobic molecules < 60 kDa) might be promising, but data proving a potential adsorption are missing so far.

Methods
The prospective Cyto-SOVLE study (NCT04913298) included 20 intensive care patients with cholestatic liver dysfunction, continuous kidney replacement therapy, total bilirubin concentration > 10 mg/dl and the application of CS into the dialysis circuit. Bilirubin and different BAs were measured pre- and post-CS at defined timepoints (10 min, 1, 3, 6, and 12 h after initiation). Relative reduction (RR, %) was calculated with: $$1-\left(\frac{\mathrm{concentration} (\mathrm{pre}-\mathrm{post})}{\mathrm{concentration} (\mathrm{pre})}\right)*100$$

1
-

concentration
(
pre
-
post
)

concentration
(
pre
)

∗
100

.

Results
The median RR for total and conjugated bilirubin after initiation was − 31.8% and − 30.3%, respectively, and decreased to − 4.5% and − 4.8% after 6 h. A high initial RR was observed for the toxic BAs GCA (− 97.4%), TCA (− 94.9%), GCDCA (− 82.5%), and TCDCA (− 86.0%), decreasing after 6 h to − 32.9%, − 32.7%, − 12.8%, and − 14.3%, respectively. The protective hydrophilic BAs showed a comparable RR after initiation (UDCA: − 77.7%, GUDCA: − 83.0%, TUDCA: − 91.3%) dropping after 6 h to − 7.4%, − 8.5%, and − 12.5%, respectively.

Conclusions
Cytosorb® can adsorb bilirubin and toxic as well as protective BAs. However, a fast saturation of the adsorber resulting in a rapid decrease of the RR was observed. Furthermore, no relevant difference between hydrophobic toxic and hydrophilic protective BAs was detected regarding the adsorption amount. The clinical benefit or harm of the BA adsorption needs to be evaluated in the future.
Beyond the bedside: protocol for a scoping review exploring the experiences of non-practicing healthcare professionals within health professions education
Authors: Church Helen R. , Brown Megan E. L. , Govender Lynelle , Clark Deborah 
Published: November 2023

Abstract
Background
The number of healthcare professionals leaving clinical practice and transitioning to alternative careers in health professions education is increasing. Among these non-practicing healthcare professionals, concerns have been reported regarding tensions in relation to identity, role, and credibility in their new field. There are suggestions that this is a particularly pressing issue for minoritised professionals who make this transition. Support is critical to attract and retain diverse talent within health professions education teaching and research. The purpose of this scoping review is to explore the career experiences of non-practicing healthcare professionals who work in health professions education internationally.

Methods
Arksey and O’Malley’s framework has been utilised to guide the design of this scoping review process and will be used throughout the course of the review. A comprehensive search of seven electronic databases and limited search of Google Scholar will be conducted, as well as a hand search of eligible article reference lists. Two reviewers will independently screen all articles based on inclusion criteria, with conflicts resolved by a third reviewer. Data from included articles will be charted, collated, and analysed thematically. Meta-data will be summarised quantitatively.

Discussion
This scoping review aims to explore the role and experiences of non-practicing healthcare professionals working within health professions education. The review will follow established scoping review guidelines and will include studies from various regions and languages, provided an English translation is available. The study remit will be broad, including both quantitative and qualitative studies, as well as reviews and opinion papers. Limitations may include the exclusion of non-English articles and potential difficulty of identifying papers which discuss the experiences of non-practicing clinicians. However, the review will provide insight into the current knowledge on what it is like to be a non-practicing clinician working within health professions education and identify gaps for both future research, and future support for those making this career transition.

Systematic review registration
Open Science Framework Registration https://doi.org/10.17605/OSF.IO/485Z3
Comprehensive classification and categorization of Qanat features: an interdisciplinary exploration using landscape infrastructure concept and semi-systematic review
Authors: Abedi Samira , Ansari Mojtaba , Haghighatbin Mahdi , Mansouri Seyed Amir 
Published: November 2023

AbstractQanats, as traditional and intelligent water infrastructures, have garnered attention across various scientific disciplines. However, a comprehensive, holistic view of Qanats remains elusive. This study aims to identify and present a thorough perspective on Qanat features. To achieve this objective, a semi-systematic review methodology was employed. The semi-systematic or narrative review approach is well-suited for subjects that span multiple disciplines and different periods. The research process commenced with an extensive search for the keyword “Qanat” within the titles and abstracts of articles across the MagIran, ScienceDirect, Taylor and Francis, and Springer databases. Subsequently, a thematic content analysis method was applied to analyze the content of these articles. Thematic content analysis involves the identification and presentation of recurring patterns in the form of distinct themes within the textual data. At this stage, Qanat features were extracted from the articles and categorized thematically. The research findings underscore the functional significance of Qanats as vital water supply systems. Furthermore, within the realm of management, Qanats are recognized as essential water infrastructures. In light of these findings, this study incorporates relevant literature from the infrastructure domain to systematically categorize Qanat features. In the research, the Landscape approach, characterized by its objective-subjective perspective, will serve as an overarching narrative framework to comprehensively classify all Qanat features. The resulting model portrays Qanats as possessing a diverse spectrum of tangible and intangible attributes, spanning environmental, cultural, social, and economic domains. This comprehensive analysis enhances our understanding of the multifaceted nature of Qanats, facilitating their preservation and sustainable management.
Could natural phytochemicals be used to reduce nitrogen excretion and excreta-derived N2O emissions from ruminants?
Authors: Zhao Yuchao , Liu Ming , Jiang Linshu , Guan Leluo 
Published: November 2023

AbstractRuminants play a critical role in our food system by converting plant biomass that humans cannot or choose not to consume into edible high-quality food. However, ruminant excreta is a significant source of nitrous oxide (N2O), a potent greenhouse gas with a long-term global warming potential 298 times that of carbon dioxide. Natural phytochemicals or forages containing phytochemicals have shown the potential to improve the efficiency of nitrogen (N) utilization and decrease N2O emissions from the excreta of ruminants. Dietary inclusion of tannins can shift more of the excreted N to the feces, alter the urinary N composition and consequently reduce N2O emissions from excreta. Essential oils or saponins could inhibit rumen ammonia production and decrease urinary N excretion. In grazed pastures, large amounts of glucosinolates or aucubin can be introduced into pasture soils when animals consume plants rich in these compounds and then excrete them or their metabolites in the urine or feces. If inhibitory compounds are excreted in the urine, they would be directly applied to the urine patch to reduce nitrification and subsequent N2O emissions. The phytochemicals' role in sustainable ruminant production is undeniable, but much uncertainty remains. Inconsistency, transient effects, and adverse effects limit the effectiveness of these phytochemicals for reducing N losses. In this review, we will identify some current phytochemicals found in feed that have the potential to manipulate ruminant N excretion or mitigate N2O production and deliberate the challenges and opportunities associated with using phytochemicals or forages rich in phytochemicals as dietary strategies for reducing N excretion and excreta-derived N2O emissions.
Downregulation of pro-surfactant protein B contributes to the recurrence of early-stage non-small cell lung cancer by activating PGK1-mediated Akt signaling
Authors: Luo Hao , Li Qing , Wang Ren-Tao , Zhang Liang , Zhang Wei , Deng Meng-Sheng , Luo Yuan-Yuan , Ji Xintong , Wen Yongheng , Zhou Xuan-Rui , Xu Bo , Wang Dong , Hu Bin , Jin Hua , Xu Cheng-Xiong 
Published: November 2023

AbstractRecurrence is one of the main causes of treatment failure in early-stage non-small cell lung cancer (NSCLC). However, there are no predictors of the recurrence of early-stage NSCLC, and the molecular mechanism of its recurrence is not clear. In this study, we used clinical sample analysis to demonstrate that low levels of expression of precursor surfactant protein B (pro-SFTPB) in primary NSCLC tissue compared to their adjacent tissues are closely correlated with recurrence and poor prognosis in early-stage NSCLC patients. In vitro and in vivo experiments showed that downregulation of pro-SFTPB expression activates the Akt pathway by upregulating PGK1, which promotes metastasis and tumorigenicity in NSCLC cells. We then demonstrated that pro-SFTPB suppresses the formation of the ADRM1/hRpn2/UCH37 complex by binding to ADRM1, which inhibits PGK1 deubiquitination, thus accelerating ubiquitin-mediated PGK1 degradation. In summary, our findings indicate that low expression of pro-SFTPB in primary NSCLC compared to their adjacent tissue has potential as a predictor of recurrence and poor prognosis in early-stage NSCLC. Mechanistically, downregulation of pro-SFTPB attenuates inhibition of ADRM1-deubiquitinated PGK1, resulting in elevated levels of PGK1 protein; this activates the Akt pathway, ultimately leading to the progression of early-stage NSCLC.
Impulsivity and sensitivity to reward as mediating factors of the negative relationship between emotional intelligence and health-related risk-taking: evidence from a sample of university students
Authors: Megías-Robles Alberto , Sánchez-López María T. , Gómez-Leal Raquel , Cabello Rosario , Gutiérrez-Cobo María José , Fernández-Berrocal Pablo 
Published: November 2023

Abstract
Background
Better abilities in emotional intelligence (EI) have been linked to a decreased tendency to engage in health-related risk behaviour. However, the processes underlying this relationship are still unclear. The aim of this research was to examine the role of impulsivity and sensitivity to reward as mediating factors in the relationship between EI and health risk-taking.

Methods
Two hundred and fifty participants (Mage = 23.60, age range = 18–59; SD = 6.67; 71.60% women) were assessed on ability EI levels, risk-taking in health contexts, impulsivity, and sensitivity to reward. Unlike previous studies in the literature, we employed a performance-based ability measure to assess EI (Mayer-Salovey-Caruso Emotional Intelligence Test, MSCEIT).

Results
The results confirmed the negative relationship between EI and health risk-taking and revealed the existence of a significant negative indirect effect of EI on health-risk taking through various dimensions of impulsivity and sensitivity to reward. EI abilities —particularly the ability to manage emotions— were associated with lower levels of impulsivity under positive and negative emotional states, a better management of the tendency towards sensation seeking, and a decreased emotional reactivity to rewards.

Conclusions
The present research provides a better understanding of the processes underlying the negative relationship between EI and health risk-taking. Our findings suggest that having higher levels of EI abilities would allow for a more objective evaluation of risk scenarios and a more appropriate and safer decision making through its influence on the levels of impulsivity and emotional reactivity to rewards. Practical implications, limitations, and future lines of research are discussed.
How standardised are antibiotic regimens in otologic surgery?
Authors: Lui Justin T. , Dahm Valerie , Arnoldner Christoph , Lam Philip W. , Le Trung N. , Chen Joseph M. , Lin Vincent Y. 
Published: November 2023

Background Within otologic surgery, a paucity of well-controlled studies assessing the use of systemic antibiotic to reduce surgical site infections exists. Moreover, discrepancies in wound classification of procedures challenge consensus in antimicrobial prescribing patterns. We sought to compare surgeons from two different health systems to examine how surgeons’ prescribing habits compared to practice guidelines for numerous otologic procedures. Methods An online questionnaire was distributed to 33 Canadian and 32 Austrian surgeons who regularly perform otologic surgery. Current systemic antibiotic prescribing habits for cochlear implantation, cholesteatoma surgery, stapes surgery, and tympanoplasty ± ossiculoplasty were collected. Results Eighteen of 33 (54.5%) Canadian surgeons provided responses, while 18 of 32 (56.3%) of Austrian surgeons answered. Clear consistency with clinical practice guidelines exists for pre-operative antibiotics use in cochlear implant surgery and infected cholesteatoma surgery. However, for stapes surgery and tympanoplasty ± ossiculoplasty, consensus is lacking for both pre- and post-operative antibiotic prescribing habits. Notable differences between the two countries include post-operative antibiotics for cochlear implant surgery (Austria: 36.4%, Canada: 71.4%) and uninfected cholesteatoma surgery (Austria: 33.3%, Canada: 77.8%). Across all procedures, both induction and post-operative antibiotic administration was not significantly associated with surgeon seniority when stratified by five-year increments. Conclusion The lack of consensus among each country's otologic surgeons underscores the uncertainty in wound classification and thus, adherence to clinical practice guidelines. Graphical Abstract