bluuebunny/crossref_metadata_2025_split huggingface dataset:
Efficacy and safety of JMT103 in patients with bone metastases from solid tumors: A randomized Phase Ib clinical trial
Authors: Ran Ran , Li Hongtao , Sun Tao , Zhou Huan , Zang Aimin , Guo Hongqian , Xie Hua , Wu Shikai , Yan Yong , Yin Xing , Xiong Hailin , Li Hong , Yuan Jing , Wang Juan , Li Huiping , Li Jin 
Published: January 2025

AbstractThis study aimed to assess the efficacy and safety of three dosing regimens of JMT103 in patients with bone metastases from solid tumors. Eligible patients were randomly assigned to receive JMT103 subcutaneously, 120 mg every 4 weeks (Cohort 1), 120 mg every 8 weeks (Cohort 2), or 180 mg every 8 weeks (Cohort 3) for up to 49 weeks. The primary endpoint was change from baseline to Week 13 in creatinine‐adjusted urinary N‐telopeptide (uNTx/Cr). Two hundred and ninety‐five patients were randomized, and 293 received at least one dose of JMT103, of whom 96 were assigned to Cohort 1, 97 were assigned to Cohort 2, and 100 were assigned to Cohort 3. The median (interquartile range) percentage reduction in uNTx/Cr at Week 13 was 80.0% (49.9%, 93.4%) in Cohort 1, 73.0% (34.5%, 94.0%) in Cohort 2, and 75.7% (40.4%, 92.0%) in Cohort 3, respectively. On‐study skeletal‐related events were reported by 3.1% of patients in Cohort 1, 6.2% in Cohort 2, and 7.0% in Cohort 3. Treatment‐emergent adverse events occurred in 289 patients, 162 of whom were deemed treatment‐related. The most common treatment‐related adverse events were hypocalcemia (23.2%), hypophosphatemia (22.9%), and increased aspartate transaminase (11.9%). JMT103 demonstrated a good safety and a strong suppression of the bone turnover markers.
Cervical cancer incidence rates considering migration status in mainland China using Bayesian model—Estimation based on 2016 cancer registry data
Authors: Du Linlin , Sun Huixin , Tang Liping , Hao Shuxiu , Feng Chen , Li Guijin , Zhang Yu , Jin Hong , Lv Cunqi , Zeng Qingyu , Wang Cheng , Li Jiacheng , Wang Xinshu , Ma Rong , Wang Tong , Li Qi 
Published: January 2025

AbstractIn mainland China, cancer registration relies on household‐registered populations, overlooking migrant populations. Estimating cervical cancer incidence among permanent residents, including migrants, offers a more accurate representation of the true burden. The data from 487 cancer registries across China in 2016 were analyzed using a Bayesian spatial regression model with the integrated nested Laplace approximation‐stochastic partial differential equation method. The study estimated cervical cancer incidence among household‐registered populations and adjusted for migrant populations using a weighting method based on interprovincial distribution and age stratification to derive the incidence of cervical cancer in the permanent residents. Data from the China Population Census, the China Migrants Dynamic Survey, and the Urban Statistical Yearbook were incorporated. The estimated crude incidence rate of cervical cancer among permanent residents was 17.4/100,000 in mainland China, with an age‐standardized incidence rate (ASIR) of 17.2/100,000. The largest disparities in cervical cancer crude incidence rate between permanent residents and household‐registered populations were observed in Guizhou (2.4/100,000, 95% CI 1.9–2.9/100,000), Zhejiang (−1.2/100,000, 95% CI −1.8 to −0.6/100,000) and Tianjin (−1.1/100,000, 95% CI −1.5 to −0.7/100,000). The number of the estimated cervical cancer incident cases was 8948. Guangdong saw an increase of 887 cases, while Henan had a decrease of 1430 cases. Guizhou had the highest ASIR (28.1/100,000), and Beijing had the lowest ASIR (11.0/100,000). The significance of this study is that it improves the accuracy of cervical cancer data in China. These findings provide evidence for developing cervical cancer prevention and control strategies, and offer insights for other countries and regions facing migration challenges.
Enhancing Functional Breast Imaging: A sCMOS Camera‐Based Lock‐in Implementation for Dynamic Tomography
Authors: Zheng Yujie , Zhang Limin , Song Weijie , Gao Feng , Liu Dongyuan 
Published: January 2025

ABSTRACTDiffuse optical tomography (DOT) enables the in vivo quantification of tissue chromophores, specifically the discernment of oxy‐ and deoxy‐hemoglobin (HbO and HbR, correspondingly). This specific criterion is useful in detecting and predicting early‐stage neoadjuvant breast cancer treatment response. To address the issues of the limited channels in the fiber‐dependent breast DOT system and limited signal‐to‐noise ratio in the camera‐dependent systems, we hereby present a camera‐based lock‐in detection scheme to achieve dynamic DOT with improved SNR, which adopted orthogonal frequency division multiplexing technology. The evaluation of the system performance was conducted on tissue phantoms and neoplastic rats, and the results show that this system boasts the capability of executing parallel measurement utilizing a camera detector, enabling the achievement of highly sensitive, and dynamic tomography for breast screening applications.
Association of Menopause and Rhinitis Among Adult Women in the United States: Findings from the All of Us Research Program
Authors: Chiu Richard G. , Eldeirawi Kamal , Dick Anthony I. , Nyenhuis Sharmilee M. , Vajaranant Thasarat Sutabutr , Caskey Rachel , Lee Victoria S. 
Published: January 2025

ObjectiveThe inflammatory role of female hormones has been garnering increased attention in the literature. Studies suggest a link between estrogen and inflammatory conditions of the airways and nasal mucosa. However, there remains a paucity of literature regarding the associations of hormones with rhinitis. Given the profound hormonal changes that occur during menopause, we sought to better understand the association between menopause and rhinitis.MethodsData from the All of Us Research Program regarding rhinitis diagnoses, menopause status, demographic variables, socioeconomic status, and comorbidities were extracted for female participants aged 40–60. Crude odds ratios (cORs) and 95% confidence intervals (CIs) were calculated for unadjusted associations between menopause and rhinitis. Variables were then included in multivariable logistic regression models, with separate models for allergic rhinitis (AR) and nonallergic rhinitis (NAR) as the outcome variables. Adjusted odds ratios (aOR) and 95% CI were calculated.ResultsWe identified 40,875 female participants aged 40–60 without any missing data. Compared with participants without rhinitis, a greater proportion of those with AR (51.6% vs. 55.6%; cOR: 1.18; 95% CI: 1.11–1.25) and NAR (51.6% vs. 58.9%; cOR: 1.34; 95% CI: 1.11–1.63) had experienced menopause. However, after controlling for covariates, menopause was associated with a decreased odds of AR (aOR: 0.89; 95% CI: 0.82–0.96) and not associated with NAR (aOR: 0.98; 95% CI: 0.77–1.24).ConclusionMenopause was independently associated with a decreased odds of AR but was not associated with NAR. Research should aim to further examine these relationships and hormonal mechanisms underlying the observed protective associations.Level of Evidence3 Laryngoscope, 2025
Usage of Milan System in Risk Stratification of Submandibular Gland Fine Needle Aspiration Cytology
Authors: Yew Wan Xin , Choy Kevin C.C. , Bundele Manish M. , Fu Ernest W. , Li Hao , Lim Ming Yann , Gan Yijin Jereme 
Published: January 2025

ObjectivesThe Milan System for Reporting Salivary Gland Cytopathology (MSRSGC) categorizes fine needle aspiration and cytology (FNAC) results into 6 tiers and assigns a risk of malignancy (ROM) to each category. Its utility in submandibular gland lesions remains unclear. Our article aims to study (1) the utility of the MSRSGC in classifying FNAC of submandibular gland masses, (2) describe the demographics and incidence of submandibular gland malignancy in our population, and (3) analyze the accuracy of FNAC in diagnosis of benign and malignant submandibular gland tumors.MethodsIn this retrospective case series, the FNAC results of 92 patients who underwent pre‐operative FNAC and excision of submandibular gland between May 2008 and December 2023 were reviewed and assigned to a MSRSGC category, and ROM was calculated based on histological diagnosis.Results20/92 (21.7%) submandibular gland excisions with pre‐operative FNAC were malignant. ROM is as follows: non‐diagnostic 7.1%, non‐neoplastic 12.5%, atypia of undetermined significance 35.3%, benign neoplasm 3.3%, salivary gland neoplasm of uncertain malignant potential 35%, suspicious for malignancy 100%, and malignant 100%.ConclusionOur study validates the usage of the MSRSGC in the work up of submandibular gland tumors.Level of Evidence4 Laryngoscope, 2025
A global dataset of nitrogen fixation rates across inland and coastal waters
Authors: Fulweiler Robinson W. , Berberich Megan E. , Rinehart Shelby A. , Taylor Jason M. , Kelly Michelle C. , Ray Nicholas E. , Oczkowski Autumn , Balint Sawyer J. , Geisser Alexandra H. , Mahoney Catherine R. , Benavides Mar , Church Matthew J. , Loeks Brianna , Newell Silvia E. , Olofsson Malin , Oppong Jimmy C. , Roley Sarah S. , Vizza Carmella , Wilson Samuel T. , Groffman Peter M. , Scott J. Thad , Marcarelli Amy M. 
Published: January 2025

AbstractBiological nitrogen fixation is the conversion of dinitrogen (N2) gas into bioavailable nitrogen by microorganisms with consequences for primary production, ecosystem function, and global climate. Here we present a compiled dataset of 4793 nitrogen fixation (N2‐fixation) rates measured in the water column and benthos of inland and coastal systems via the acetylene reduction assay, 15N2 labeling, or N2/Ar technique. While the data are distributed across seven continents, most observations (88%) are from the northern hemisphere. 15N2 labeling accounted for 67% of water column measurements, while the acetylene reduction assay accounted for 81% of benthic N2‐fixation observations. Dataset median area‐, volume‐, and mass‐normalized N2‐fixation rates are 7.1 μmol N2‐N m−2 h−1, 2.3 × 10−4 μmol N2‐N L−1 h−1, and 4.8 × 10−4 μmol N2‐N g−1 h−1, respectively. This dataset will facilitate future efforts to study and scale N2‐fixation contributions across inland and coastal aquatic environments.
Exceptional Absorption in a Deep‐Subwavelength Plasmonic Film
Authors: Zhang Yiyun , Feng Yiming , Lepage Dominic , Gao Bingtao , Peng Xiyao , Zhao Sihan , Ma Yaoguang , Shen Yichen , Chen Hongsheng , Li Shilong , Qian Haoliang 
Published: January 2025

AbstractIn the realm of photonic integrated circuit design, on‐chip absorbers are imperative for preventing signal degradation caused by unintended stray photons, which induce signal crosstalk and operational errors. An ideal on‐chip optical absorber is expected to have a superior absorption capability across a wide range of frequencies while maintaining a minimal footprint. However, widely employed optical thin‐film absorbers suffer from limited absorption due to inherent refractive index mismatches and short light‐matter interaction lengths. Here a ≈45‐nm thin metalayer is demonstrated that exhibits uniformly high absorption over a broad wavelength range from 350 nm to 4.5 µm in a wide range of incident angles up to over 60 degrees. The metalayer's performance notably exceeds the absorption predicted by standard plane‐wave optics theories, potentially attributing to the Anderson localization effect. Integration of such a deep‐subwavelength metalayer absorber into photonic circuits will facilitate the creation of highly efficient photonic chips, propelling the advancement of optical communication and computing.
Disco‐Interacting Protein 2 Homolog B CGG Repeat Expansion in Siblings with Neurodevelopmental Disability and Progressive Movement Disorder
Authors: Théberge Emilie T. , Durbano Kate , Demailly Diane , Huby Sophie , Mitina Aleksandra , Yin Yue , Mohajeri Arezoo ,   Care4Rare Canada Consortium, van Karnebeek Clara , Horvath Gabriella A. , Yuen Ryan K.C. , Usdin Karen , Lehman Anna , Cif Laura , Richmond Phillip A. 
Published: January 2025

AbstractBackgroundTrinucleotide repeat expansions are an emerging class of genetic variants associated with various movement disorders. Unbiased genome‐wide analyses can reveal novel genotype–phenotype associations and provide a diagnosis for patients and families.ObjectiveThe aim was to identify the genetic cause of a severe progressive movement disorder phenotype in 2 affected brothers.MethodsA family of 2 affected brothers and unaffected parents had extensive phenotyping since birth. Whole‐genome and long‐read sequencing methods characterized genetic variants and methylation status.ResultsTwo male siblings with a CGG repeat expansion in the 5′‐untranslated region (UTR) of disco‐interacting protein 2 homolog B (DIP2B) presented with a novel DIP2B phenotype, including neurodevelopmental disability, dysmorphic traits, and a severe progressive movement disorder (chorea, dystonia, and ataxia).ConclusionsThis is the first report of a severe progressive movement disorder phenotype associated with a CGG repeat expansion in the DIP2B 5′‐UTR. © 2025 International Parkinson and Movement Disorder Society. This article has been contributed to by U.S. Government employees and their work is in the public domain in the USA.
The Effect of Nonlinearities With Arbitrary‐Order Derivatives on Dynamic Transitions
Authors: Şengül Taylan , Tiryakioglu Burhan 
Published: January 2025

ABSTRACTThe primary objective of this paper is to classify the first transitions of a general class of one spatial dimensional nonlinear partial differential equations on a bounded interval. The linear part of the equation is assumed to have a real discrete spectrum with a complete set of eigenfunctions, which are of the form or . The nonlinear operator consists of arbitrary finite products and sums of the unknown function and its derivatives of arbitrary order. The equations allow for a trivial steady‐state solution that becomes unstable when a control parameter exceeds a certain threshold. Unlike most of the previous research in this direction that considers specific equations, this general framework is suitable for extension in several directions such as the higher spatial dimensions and different basis vectors. Under a set of assumptions that are often valid in many interesting applications, we derive two numbers called the transition number and the critical index which completely describe the first dynamic transition. We make detailed numerical computations that reveal the properties of the transition numbers. To show the applicability of our theoretical results, we determine the first transitions of several well‐known equations including the Cahn–Hilliard, thin film, Harry Dym, Kawamoto, and Rosenau–Hyman equations.
Treatment Utilisation and Satisfaction With Management in Individuals With Osteoarthritis and Metabolic Multimorbidity: A Cross‐Sectional Multi‐Country Study
Authors: Recenti Filippo , Dell'isola Andrea , Giardulli Benedetto , Testa Marco , Pchelnikova Polina , Ndosi Mwidimi , Battista Simone 
Published: January 2025

ABSTRACTPurposeTo compare treatment utilisation for osteoarthritis (OA) and satisfaction with OA management between individuals with and without comorbid metabolic conditions (e.g., diabetes, obesity, dyslipidaemia, hypertension).MethodsSecondary analysis of a cross‐sectional international survey study (Italy, Russia, Sweden) on people ≥ 40 years old with knee/hip OA. Metabolic comorbidity was self‐reported. We used direct standardisation with prevalence ratios and mixed‐effect models to estimate the associations between comorbidity with treatment utilisation and satisfaction (score 0–100).ResultsWe analysed 401 individuals (48% Sweden, 28% Italy, 24% Russia; 53% with ≥ 1 metabolic condition). Those with and without comorbid metabolic conditions showed similar prevalence for first‐line interventions (exercise, education, and weight management). Metabolically unhealthy individuals showed higher use of opioids (prevalence ratio [95% CI] 1.9 [1.3–2.4]), antidepressants (1.8 [1.1–2.5]), corticosteroid injections (1.4 [1.0−1.8]), and homoeopathic products (2.1 [1.2–3.0]). Satisfaction with care (adjusted difference: −3.9 [95% CI: −8.5 to 2.4]) and information received about treatments (−4.0 [−9.7 to 1.7]) were similar.ConclusionsWhile first‐line OA interventions were similarly used, those with metabolic conditions relied more on second‐line and non‐recommended treatments, showing comparable satisfaction. More effort is needed to increase the adoption of lifestyle‐focused treatments in OA and to minimise the use of less recommended options among individuals with metabolic comorbidities.
Prophylactic Use of Cardiac Medications and Survival in Duchenne Muscular Dystrophy
Authors: Conway Kristin M. , Thomas Shiny , Neyaz Tahereh , Ciafaloni Emma , Mann Joshua R. , Staron‐Ehlinger Michelle , Beasley Gary S. , Romitti Paul A. , Mathews Katherine D. ,   the Muscular Dystrophy Surveillance, Tracking and Research Network (MD STARnet)
Published: January 2025

ABSTRACTIntroduction/AimsProphylactic treatment of left ventricular dysfunction (LVD) in Duchenne muscular dystrophy (DMD) delays onset of LVD, but there is limited data showing impact on survival. Our aim was to describe survival among treated and untreated individuals with DMD.MethodsRetrospective, population‐based surveillance data from the Muscular Dystrophy Surveillance, Tracking and Research Network (MD STARnet) were used. We analyzed 327 males with DMD born between 1982 and 2009 who were at least 6 years old at the last visit and who initiated cardiac prophylactic medication before age 14 years. Death status was ascertained through vital record linkages and medical record review. Prophylaxis was defined as cardiac medication use at least 1 year before LVD onset (ejection fraction < 55% or shortening fraction < 28%). Age at first visit, corticosteroid use, scoliosis surgery, initiation of noninvasive ventilation, and loss of ambulation were also coded. Cox Proportional Hazard modeling with time‐varying covariates describes associations.ResultsProphylactic cardiac treatment was documented for 27.7% (n = 90); corticosteroids were used by 60.9% (n = 157). Adjusting for age at first visit and MD STARnet site, prophylactic treatment was associated with a 54% lower hazard of death (HR = 0.46, 95% CI = 0.22–0.93) compared to no prophylaxis. Adjusting for selected clinical covariates did not appreciably change the estimate (HR = 0.46, 95% CI = 0.22–0.99).DiscussionInitiation of cardiac medication when left ventricular function is normal was associated with prolonged survival in this study of males with DMD. Only one‐quarter of individuals received this treatment, however, indicating a topic of focus for improving care.
Thoracic Electric Impedance Tomography Detects Lung Volume Changes in Amyotrophic Lateral Sclerosis
Authors: Hansen Gregory , Shaw Adam , Bolt Kala , Verity Ryan , Nataraj Richard T. , Schellenberg Kerri Lynn 
Published: January 2025

ABSTRACTIntroduction/AimsSpirometry is the conventional means to measure lung function in amyotrophic lateral sclerosis (ALS), but is dependent on patient effort and bulbar strength. We aimed to use electric impedance tomography (EIT), an emerging non‐invasive imaging modality, to measure dynamic lung volume changes.MethodsTwenty‐one patients with ALS underwent sitting and supine spirometry for forced vital capacity (FVC), and sitting and supine EIT. There were 13 patients in the high FVC group (FVC ≥ 80% predicted) and 8 in the low FVC group (FVC < 80% predicted). Additional demographic and clinical data were collected from clinical records.ResultsOnly the low FVC group had significant loss of lung volumes in the supine position (R2 = 0.89 and p < 0.001). The supine volume loss measurement at 10 min correlated with sitting (r2 = 0.47) and supine FVC (r2 = 0.36), maximum inspiratory (r2 = −0.44) and expiratory pressures (r2 = 0.36) (MIP and MEP), and the ALS Functional Rating Scale‐Revised (ALSFRS‐R) dyspnea subscore (r2 = 0.36).DiscussionEIT is an emerging alternative to existing measures of lung function in ALS, but without need for patient effort or bulbar strength. Significant losses in lung volume are seen on supine compared to upright position in patients with respiratory dysfunction. Further study is needed to determine relationships to existing clinical measures.
Sub‐Tree Scheduling for Wireless Sensor Networks With Partial Coverage: Complexity and Polynomial‐Size Formulations
Authors: Barbato Michele , Bianchessi Nicola 
Published: January 2025

ABSTRACTGiven an undirected graph whose edge weights change over time slots, the sub‐tree scheduling for wireless sensor networks with partial coverage asks to partition the vertices of in non‐empty trees such that the total weight of the trees is minimized. In this article, we show that the problem is NP‐hard in both the cases where is part of the input and is a fixed instance parameter. In both our proofs we reduce the cardinality of the Steiner tree problem. Then, in order to provide easy‐to‐implement and effective computational tools to benchmark heuristics, we introduce new polynomial‐size integer linear programming formulations for the problem. Being defined by a polynomial number of variables and constraints, the formulations can be used to address instances of the problem by means of off‐the‐shelf mixed‐integer linear programming solvers with minimum implementation efforts. All proposed formulations share the property that the integrality requirement can be relaxed on subsets of variables. This enables several algorithmic choices to solve the models, including Benders' decomposition approaches and branch‐and‐bound with specific branching priorities. We experimentally identify the best resolution method for each formulation. Moreover, the experimental results obtained on benchmark instances of the problem, compared against those reported in the literature, support the effectiveness arising from using the new proposed formulations.
Dynamic Properties and Vibration Response of Polymer Matrix Composites: Mechanisms, Influences, and Applications in Engineering
Authors: Kumar Jeetesh , Panchore Vijay , Rajak Dipen Kumar , Joshi Tilak 
Published: January 2025

ABSTRACTPolymer matrix composites (PMCs) are critical materials in vibration‐intensive applications, including aerospace, automotive, naval, and sports sectors, where understanding their dynamic behavior is essential for reliable performance. This study comprehensively reviews PMCs' dynamic properties, focusing on their vibration response and damping characteristics. It explores the influence of material parameters, such as matrix composition, fiber orientation, stacking sequence, and nanoparticle incorporation, on natural frequencies and damping ratios. Experimental techniques like dynamic mechanical analysis and fast Fourier transform, alongside computational and analytical methods, including finite element analysis and classical theory, are utilized to evaluate these properties. Key findings reveal that natural fibers like kenaf and hamp enhance damping for eco‐friendly applications, while synthetic fibers and nanoparticles, such as multi‐walled carbon nanotubes, improve frequency response but may reduce damping. The effects of temperature sensitivity and chemical treatments are also discussed, emphasizing their role in optimizing vibrational performance. Analytical models and numerical simulations validate these findings, providing insights into structural design. This work bridges knowledge gaps by integrating experimental and theoretical approaches and offers practical strategies for developing lightweight, vibration‐resistant PMCs tailored for critical engineering applications. Future research should focus on optimizing material–environment interactions for advanced applications.