bluuebunny/crossref_metadata_2025_split huggingface dataset:
Biological, Biomechanical, and Histopathological Evaluation of Polyetherketoneketone Bioactive Composite as Implant Material
Authors: Al‐Samaray Manar E. , Fatalla Abdalbseet A. 
Published: January 2025

ABSTRACTWhile polyetherketoneketone is a high‐performance thermoplastic polymer, its hydrophobicity and inertness limit bone adhesion. This study aimed to evaluate a novel PEKK/CaSiO3/TeO2 nanocomposite, comparing it to PEKK/15 wt.% CaSiO3 and PEKK groups. The in vitro study, involving 90 discs (n = 30), assessed the cytotoxicity of all groups after 24, 72, and 168 h. The in vivo animal study, using cylinder‐type implants (n = 30), evaluated osseointegration through biomechanical push‐out tests, descriptive histopathological examinations of decalcified sections stained with hematoxylin and eosin, and histomorphometric analysis of new bone formation area after 2‐ and 6‐week healing intervals. The cytocompatibility of PEKK/15 wt.% CaSiO3/1 wt.% TeO2 composite confirmed its acceptance as a biomedical material. Additionally, in vivo study results showed that the PEKK/15 wt.% CaSiO3/1 wt.% TeO2 had the highest shear strength value and the highest new bone formation area compared to other experimental groups. The multimodal concept of adding CaSiO3 micro fillers and TeO2 nanofillers to PEKK produces a cytocompatible composite that enhances osseointegration and new bone formation in a rabbit's femur after 2‐ and 6‐week healing intervals.
A Highly Correlated, Multireference Study of the Lowest Lying Singlet and Triplet States of the Four Thiophene Diradicals
Authors: Pandian Joshua , Vu Khanh , Muya Jules Tshishimbi , Parker Anna , Ancajas Christine Mae F. , Saldana‐Greco Diomedes , Yewer Tabitha , Parish Carol 
Published: January 2025

ABSTRACTThe energies and geometries of the lowest lying singlet and triplet states of the four diradicals formed by removing two H atoms from thiophene have been characterized. We utilized the highly correlated, multireference methods configuration interaction with single and double excitations with and without the Pople correction for size‐extensivity (MR‐CISD+Q and MR‐CISD) and averaged quadratic coupled cluster theory (MR‐AQCC). CAS (8,7) and CAS (10,8) active spaces involving σ, σ*, π, and π* orbitals were employed along with the cc‐pVDZ and cc‐pVTZ basis sets. The larger active space included the two electrons in the nonbonding sp2 hybrid orbital on sulfur. We find that all didehydro isomers exist as planar, stable ground state singlets. The singlet‐triplet (S‐T) adiabatic gaps range from 15 to 25 kcal/mol while the vertical splittings are 21–35 kcal/mol. The 2,3 isomer has the lowest absolute ground state singlet energy and the largest adiabatic and vertical S‐T splitting. The ground states of the 2,3‐, and 2,5‐didehydrothiophene isomers are predicted to exhibit the smallest and largest diradical character, respectively, based on their electronic structures, spin densities and bonding analysis. To our knowledge, no experimental excitation energies of any of the didehydrothiophene isomers are available, and our computed MR‐AQCC/cc‐pVTZ data are believed to be among the most accurate computed results. This extensive study shows a competitive performance between MR‐AQCC and MR‐CISD+Q.
Safety and Efficacy of a 6‐Month Placement of a Fully Covered Self‐Expanding Metallic Stent for Refractory Benign Biliary Stricture: A Multicenter Prospective Study
Authors: Iwai Tomohisa , Kida Mitsuhiro , Sugimori Kazuya , Shigoka Hiroaki , Matsumoto Takaaki , Ijima Masashi , Miwa Haruo , Okuwaki Kosuke , Watanabe Masafumi , Adachi Kai , Tamaki Akihiro , Hanaoka Taro , Ishizaki Junro , Kusano Chika 
Published: January 2025

ABSTRACTBackground and AimManaging benign biliary stricture endoscopically is complicated and challenging. This study aimed to evaluate the safety and efficacy of a 6‐month placement of a fully covered self‐expanding metallic stent for refractory benign biliary stricture.MethodsTwenty‐two patients with refractory benign biliary stricture (13 with chronic pancreatitis and 9 without) were recruited from five higher tertiary care centers. All patients received a planned 6‐month fully covered self‐expanding metallic stent placement. Primary outcomes included clinical success, technical success of stent removal, adverse events, and stricture recurrence.ResultsOf the 21 cases (one case was excluded owing to malignant findings), fully covered self‐expanding metallic stent placement was successful in all cases, with contralateral bile duct plastic stents used in three patients and stents remaining in place for 6 months in 16 of 21 patients. Distal stent migration occurred in three cases, two of which had resolved strictures. Adverse events were observed in 19.0% of patients: one case of severe cholangitis, two cases of mild cholangitis, and one case of hyperplasia formation. No stent‐induced pancreatitis or cholecystitis occurred. All stents were removed successfully, and the treatment success rate was 85%. One patient experienced recurrent stricture 6.5 months post‐stent removal.ConclusionsA six‐month placement of a modified fully covered self‐expanding metallic stent effectively improved strictures and minimized stent‐induced Adverse events in patients with refractory benign biliary stricture.Trial RegistrationUMIN ID: UMIN000025027
Combined Proteasome and Autophagy Inhibition in Relapsed/Refractory Multiple Myeloma—A Phase I Trial of Hydroxychloroquine, Carfilzomib, and Dexamethasone
Authors: Slørdahl Tobias S. , Askeland Frida Bugge , Hanssen Margrete Sofie Sætre , Hov Håkon , Sundt‐Hansen Stine Marie , Lindahl Sofia , Vethe Nils Tore , Hjorth‐Hansen Henrik , Fenstad Mona H. , Waage Anders , Hjertner Øyvind , Schjesvold Fredrik , Sundan Anders 
Published: January 2025

ABSTRACTMultiple myeloma is characterized by malignant cells which produce high amounts of monoclonal immunoglobulin. Myeloma cells are, therefore, dependent on effective protein degradation. Proteasomal protein degradation is targeted by proteasome inhibitors in routine care. Autophagic protein degradation is currently not targeted in myeloma treatment. This Phase I trial showed that the combination of the proteasome inhibitor carfilzomib and the autophagy inhibitor hydroxychloroquine was well tolerated in patients with relapsed/refractory multiple myeloma. Adverse events were mostly Grades 1 and 2. An overall response rate of 44% indicates a meaningful clinical efficacy of this combination.Trial Registration: The study was registered at clinicaltrials.gov # NCT04163107.
Defibrotide for the Treatment of Veno‐Occlusive Disease/Sinusoidal Obstruction Syndrome in Paediatric Patients Who Did Not Receive Haematopoietic Stem Cell Transplantation: Case Reports of Patients From a German Academic Hospital
Authors: Kleinschmidt Katharina , Troeger Anja , Föll Jürgen , Hanafee‐Alali Tarek , Jakob Marcus , Kramer Sonja , Kietz Silke , Corbacioglu Selim 
Published: January 2025

ABSTRACTIntroductionVeno‐occlusive disease/sinusoidal obstruction syndrome (VOD/SOS) is a potentially life‐threatening condition characterised by obstruction of the small veins of the liver. Although typically associated with haematopoietic stem cell transplantation, VOD/SOS may also occur following intensive multimodal chemotherapy regimens. In children, symptoms of VOD/SOS are refractory thrombocytopaenia, weight gain, hepatomegaly, ascites and fluid retention, hyperbilirubinaemia and sometimes right upper quadrant pain.MethodsHere, we present a case series of six paediatric patients with acute lymphoblastic leukaemia who developed severe VOD/SOS while receiving standard AIEOP‐BFM ALL protocol treatment.Results/ConclusionsAll patients responded promptly to defibrotide treatment and exhibited favourable clinical outcomes.Trial RegistrationThe authors have confirmed clinical trial registration is not needed for this submission
Novel omnipolar mapping technology for effective superior vena cava isolation: A randomized clinical trial
Authors: Oguri Naoto , Okubo Yousaku , Ishibashi Naoki , Maeda Junji , Sakai Takumi , Uotani Yukimi , Furutani Motoki , Miyamoto Shogo , Miyauchi Shunsuke , Okamura Sho , Tokuyama Takehito , Oda Noboru , Nakano Yukiko 
Published: January 2025

AbstractBackgroundSuccessful isolation of the superior vena cava (SVC) using a functional conduction block between the right atrium (RA) and SVC has been documented. However, a comparison of this approach with the conventional method (CM) of circumferential ablation of the RA‐SVC junction, based on angiography, remains unexplored.ObjectiveIn this study, we employed the innovative omnipolar mapping technology (OT) to discern the RA‐SVC connection and compared clinical outcomes with those from CM.MethodsSixty‐two patients undergoing SVC isolation were randomly assigned in a 1:1 ratio to either the OT or CM group. No significant differences in the baseline characteristics were observed between the two groups. We assessed the efficacy and safety of both groups.ResultsBoth groups showed comparable acute success rates (96%) in SVC isolation, but the procedure in the OT group required fewer radiofrequency (RF) applications (13.6 ± 6.0 vs. 19.8 ± 10.9, p = .046) and shorter procedure time (9.6 ± 6.8 min vs. 14.3 ± 6.8 min, p = .007). The overall absorbed dose was notably lower in the OT group (69.6 ± 47.6 mGy vs. 90.3 ± 30.3 mGy, p = .023).ConclusionsThe OT enhances the efficacy of SVC isolation, requiring fewer RF applications and reducing procedure time compared to conventional treatment methods.
Rapid Separation of Representative Monomer Compound Rutin From Natural Product by Molecularly Imprinted Macroporous Adsorption Resin
Authors: Qi Yubai , Jin Xueqin , Yang Yuepeng , Du Hong , Li Defu , Li Xinying 
Published: January 2025

ABSTRACTMonomer compounds from natural products are the major source of active pharmaceutical molecules, which provide great opportunities for discovering of new drugs. However, natural products contain a large number of rather complex compounds. It is difficult to obtain high‐purity monomer compounds from complex natural products. Herein, we developed molecularly imprinted macroporous adsorption resins (MIRs‐PDA) for the selective adsorption of target monomer compounds from natural products. The response surface methodology was employed to optimize the fabrication parameters. The separation performance of MIRs‐PDA for the representative monomer compound rutin was thoroughly studied. We found that MIRs‐PDA presented large adsorption capacity (107.82 mg/g), high selectivity (selectivity coefficient was 2.90), good repeatability, and reusability. MIRs‐PDA can reach 78.5% equilibrium adsorption capacity in 20 min, showing quick binding kinetic behavior. Furthermore, MIRs‐PDA showed good selective and specific adsorption performance for rutin from a representative real sample of Fagopyrum tataricum extract solution. The study of the adsorption mechanism showed that the adsorption of rutin on MIRs‐PDA was spontaneous and thermodynamically feasible. The kinetic parameters adapted well to the pseudo‐second‐order kinetic model, and there existed equivalent binding sites in MIRs‐PDA. The MIRs‐PDA show promising application prospects for the separation of monomer compounds in natural products.
No difference in ACL revision rates between hamstring and patellar tendon autograft in patients with ACL‐R and a concurrent meniscal injury irrespective of meniscal treatment
Authors: Högberg Johan , Petersson Lina , Zsidai Bálint , Horvath Alexandra , Cristiani Riccardo , Samuelsson Kristian , Hamrin Senorski Eric 
Published: January 2025

AbstractPurposeThe aims of this study were to compare (1) the rate of anterior cruciate ligament (ACL) revision and (2) subjective knee function using the Knee injury and Osteoarthritis Outcome Score (KOOS) between isolated ACL reconstruction (ACL‐R) and ACL‐R and concurrent meniscal injury, based on graft selection and meniscal treatment.MethodsData from the Swedish National Knee Ligament Registry were extracted in November 2022 for patients who underwent primary ACL‐R. Patients were divided into two main groups based on graft choice: hamstring tendon (HT) or patellar tendon (PT) autograft, with four meniscal sub‐groups: no injury, resection, repair or left in situ. The primary outcome was the rate of ACL revision within 5 years of primary ACL‐R, and the secondary outcome was subjective knee function measured with the mean KOOS subscale scores and the rate of patients achieving a patient‐acceptable symptom state (PASS) at the 1‐, 2‐ and 5‐year follow‐up.ResultsThe analysis of ACL revision was performed on 45,656 patients, and 7639 patients for the analysis of subjective knee function. The overall rate of ACL revision was 2.4% and 4.9% at 2 and 5 years, respectively. There were no differences in the rate of ACL revision within 5 years of primary surgery irrespective of graft choice or meniscal injury treatment. Patients with ACL‐R and concurrent meniscal resection or meniscal injury left in situ achieved a PASS at the 1 (∆ = −11.3% to −29.5%), 2 (∆ = −12.7% to −40.3%) and 5‐year (∆ = −12.0% to −30.6%) follow‐up to a greater extent when receiving HT autograft compared to PT autograft.ConclusionGraft selection was not associated with ACL revision in patients with ACL‐R and concurrent meniscal injury, regardless of meniscal injury treatment. Superior subjective knee function was reported by patients who underwent ACL‐R with HT autograft compared with PT autograft where the injured meniscus was resected or left in situ.Level of EvidenceLevel III.
Genetics of Primary Adrenal Insufficiency Beyond CAH in Saudi Arabian Population
Authors: Al‐Hamed Mohamed H. , Qari Alya , Alrayes Lamya , Alotaibi Mohammed , Al Masseri Zainab , Alotaibi Afaf , AlAshwal Abdullah , AlHassnan Zuhair N. , Alsagheir Afaf 
Published: January 2025

ABSTRACTBackgroundThe use of exome sequencing (ES) has helped in detecting many variants and genes that cause primary adrenal insufficiency (PAI). The diagnosis of PAI is difficult and can be life‐threatening if not treated urgently. Consanguinity can impact the detection of recessively inherited genes. Here, we report families with PAI in a consanguineous population of Saudi Arabia.Materials and MethodsA cohort of 47 PAI patients (41 males and six females) representing 30 families was recruited. The cohort excluded congenital adrenal hyperplasia (CAH) cases and had a known consanguinity of 70%. Using ES, molecular genetic causes of PAI were investigated.ResultsIn 30 unrelated families with PAI, pathogenic/likely pathogenic variants were detected in 27 families with a diagnostic yield of (90%). Clinically associated variants of uncertain significance (VUS) were identified in a further two PAI families (7%). Hemizygous variants in ABCD1 were the most common cause of PAI in this cohort (16 families) leading to adrenoleukodystrophy. A total of six novel variants were detected, of which four were predicted to be pathogenic (P) / likely pathogenic (LP) and two were VUS. Four pathogenic variants in ABCD1, NR0B1, and MC2R were detected in 10 families suggesting founder mutations.ConclusionIn this cohort, ES detected a diagnostic molecular abnormality in 90% of patients with PAI phenotypes. X‐linked inheritance is the most common cause of PAI and founder mutations likely contributed to a high diagnostic yield.
Simple User‐Friendly Reaction Format
Authors: Nippa David F. , Müller Alex T. , Atz Kenneth , Konrad David B. , Grether Uwe , Martin Rainer E. , Schneider Gisbert 
Published: January 2025

AbstractUtilizing the growing wealth of chemical reaction data can boost synthesis planning and increase success rates. Yet, the effectiveness of machine learning tools for retrosynthesis planning and forward reaction prediction relies on accessible, well‐curated data presented in a structured format. Although some public and licensed reaction databases exist, they often lack essential information about reaction conditions. To address this issue and promote the principles of findable, accessible, interoperable, and reusable (FAIR) data reporting and sharing, we introduce the Simple User‐Friendly Reaction Format (SURF). SURF standardizes the documentation of reaction data through a structured tabular format, requiring only a basic understanding of spreadsheets. This format enables chemists to record the synthesis of molecules in a format that is understandable by both humans and machines, which facilitates seamless sharing and integration directly into machine learning pipelines. SURF files are designed to be interoperable, easily imported into relational databases, and convertible into other formats. This complements existing initiatives like the Open Reaction Database (ORD) and Unified Data Model (UDM). At Roche, SURF plays a crucial role in democratizing FAIR reaction data sharing and expediting the chemical synthesis process.
G$$ G $$‐Convergence of Friedrichs Systems Revisited
Authors: Burazin K. , Erceg M. , Waurick M. 
Published: January 2025

ABSTRACTWe revisit the homogenization theory for Friedrichs systems. In particular, we show that ‐compactness can be obtained under severely weaker assumptions than in the original work of Burazin and Vrdoljak (2014). In this way, we extend the applicability of ‐compactness results for Friedrichs systems to equations that yield memory effects in the homogenized limit and detour any usage of compactness techniques previously employed.MSC2020 Classification: 35B27, 35F45, 35M32, 47F05
‘Despite the Pain, I Keep Moving Forward’: A Qualitative Study on Brazilian Older Adults' Experiences With Chronic Low Back Pain
Authors: Pellegrini Marina Jacobucci , Meziat‐Filho Ney , Fernandez Jessica , Costa Nathalia 
Published: January 2025

ABSTRACTObjectiveThe burden of chronic low back pain (CLBP) is increasing rapidly along with the global population ageing. Such an increase will occur more rapidly in low‐ and middle‐income countries (LMICs). Yet, few studies have explored the experiences of older adults with CLBP, and these are primarily conducted in high‐income countries. To address this concern, we explored the experiences of older Brazilian adults with CLBP.MethodsWe used a descriptive qualitative study and gathered data through interviews and drawings from participants representing their experiences. Data were analysed using reflexive thematic analysis principles.ResultsWe interviewed 22 participants and identified the following themes: (1) Low back pain: an intense sensory and emotional experience; (2) causes of pain: wear and tear due to ageing, physical overload and emotional overload; (3) seeking treatment and not improving; (4) health professionals with a biomedical and pessimistic view; (5) the impact of pain on life: functional limitations and social repercussions; and (6) dealing with pain through movement, resilience and passive strategies.ConclusionsParticipants described CLBP as a sensory and emotional experience that impacts various aspects of their lives. Wear and tear due to ageing, physical and emotional overload were highlighted as causes of pain, and health professionals as a source of pessimism. Despite this, many participants discussed coping through movement, resilience, and passive strategies. Health professionals should address the emotional aspects associated with CLBP, explore its impact on their patients' lives and provide information that aligns with current evidence, promoting reassurance and a multidimensional understanding of CLBP.
Adaptive Parallelizable Algorithms for Interpolative Decompositions via Partially Pivoted LU
Authors: Pearce Katherine , Chen Chao , Dong Yijun , Martinsson Per‐Gunnar 
Published: January 2025

ABSTRACTInterpolative decompositions (ID) involve “natural bases” of row and column subsets, or skeletons, of a given matrix that approximately span its row and column spaces. Although finding optimal skeleton subsets is combinatorially hard, classical greedy pivoting algorithms with rank‐revealing properties like column‐pivoted QR (CPQR) often provide good heuristics in practice. To select skeletons efficiently for large matrices, randomized sketching is commonly leveraged as a preprocessing step to reduce the problem dimension while preserving essential information in the matrix. In addition to accelerating computations, randomization via sketching improves robustness against adversarial inputs while relaxing the rank‐revealing assumption on the pivoting scheme. This enables faster skeleton selection based on LU with partial pivoting (LUPP) as a reliable alternative to rank‐revealing pivoting methods like CPQR. However, while coupling sketching with LUPP provides an efficient solution for ID with a given rank, the lack of rank‐revealing properties of LUPP makes it challenging to adaptively determine a suitable rank without prior knowledge of the matrix spectrum. As a remedy, in this work, we introduce an adaptive randomized LUPP algorithm that approximates the desired rank via fast estimation of the residual error. The resulting algorithm is not only adaptive but also parallelizable, attaining much higher practical speed due to the lower communication requirements of LUPP over CPQR. The method has been implemented for both CPUs and GPUs, and the resulting software has been made publicly available.
Topology Optimization of Contact‐Aided Thermo‐Mechanical Regulators
Authors: Dalklint Anna , Alexandersen Joe , Frederiksen Andreas Henrik , Poulios Konstantinos , Sigmund Ole 
Published: January 2025

ABSTRACTTopology optimization is used to systematically design contact‐aided thermo‐mechanical regulators, i.e., components whose effective thermal conductivity is tunable by mechanical deformation and contact. The thermo‐mechanical interactions are modeled using a fully coupled non‐linear thermo‐mechanical finite element framework. To obtain the intricate heat transfer response, the components leverage self‐contact, which is modeled using a third medium contact method. The effective heat transfer properties of the regulators are tuned by solving a topology optimization problem using a traditional gradient‐based algorithm. Several designs of thermo‐mechanical regulators in the form of switches, diodes, and triodes are presented.
The Mediating Role of Emotional Intelligence in the Organisational Commitment and Turnover Intention of Clinical Nurses: A Cross‐Sectional Study
Authors: Lingyu Han , Ruiling Li , Yiman Wang , Yafeng Liu , Xiaolu Bai 
Published: January 2025

ABSTRACTAimTo explore the influence of emotional intelligence and organisational commitment (OC) on clinical nurses' turnover intention (TI) and to provide intervention strategies to reduce the turnover rate of nursing staff and maintain the stability of the nursing team.DesignA cross‐sectional descriptive study was conducted with nurses (n = 452) in a tertiary hospital in Kaifeng City, Henan Province, China.MethodsThe project was conducted in July 2023. The data were collected using the organisational commitment scale, Wong and Law emotional intelligence scale and turnover intention scale.ResultsThe emotional intelligence score of clinical nurses was (3.07 ± 0.68), organisational commitment scale was (3.04 ± 0.68), and turnover intention scale was (2.70 ± 0.58). Organisational commitment scale and emotional intelligence scores are negatively correlated with turnover intention; the mediating effect of emotional intelligence in organisational commitment and turnover intention scale of clinical nurses is −0.406, and the mediating effect accounts for 49.9%.Public ContributionNurses' organisational commitment can directly predict turnover intention, and emotional intelligence plays a role in mediating the relationship between nurses' organisational commitment and turnover intention. This research makes a substantial contribution to the public and healthcare sector. The findings provide valuable insights for healthcare administrators, policy‐makers and educators, offering evidence‐based strategies to improve nurse retention and enhance the quality of patient care. It is important to note that the research upholds the highest standards of integrity, with a meticulous review process and a dedicated effort to maintain data quality.