bluuebunny/crossref_metadata_2025_split huggingface dataset:
Nigerian Agricultural Posts on Facebook and Instagram within the West African Agricultural Messaging Framework
Authors: Aliagan Isiaka Zubair , Ahmad Murtada Busair , Daranijo Habeeb Opeyemi , Na’allah Habibat Morenikeniji 
Published: November 2023

This study generated and content-analyzed Facebook and Instagram postings on agricultural messages by Nigerian farmers in three years (2019-2021) within specific contexts and in comparison with postings similar to ones initiated by private individuals and government agencies as well as those posted at continental level on the two social media channels. While the data are graphically displayed, a paired-sample T-test was conducted to establish statistically significant differences in the agricultural messages posted on the two social media by Nigerian farmers and farmers from other countries in Africa. All four null hypotheses tested were rejected as statistically significant differences were established between the paired population means. It was also found that Nigerian farmers are accustomed to the use of social media in promoting agricultural-related messages, indicating their exposure to the diffusion of agricultural innovation in line with the trends in advanced nations. It was concluded that social media remains a viable tool for promoting agriculture, particularly during food insecurity and global economic crisis. It was recommended that the Nigerian government should provide an enabling environment for agricultural promotion in the digital age.
A stockpile of neonatal antibodies pertaining to SARS Covid (COVID 19) ascertained in cord blood after complete vaccination of covishield in mother- An observational study
Authors: Krishna Abhishek S , Adithya S L  , Ahalya U  , Anil Akhila , Amal A  , Dharan Shaiju S 
Published: November 2023

Maternal antibodies are a vital component of neonatal immunity. These antibodies give the baby a head start in building their immune system and fighting off diseases. The study was carried out to check the presence of IgG antibodies in cord blood of a completely vaccinated mother with Covishield and to find out if any side effects occurred during their vaccination. It was clear from the study that all the cord blood samples showed presence of antibodies and only limited side effects were observed in the vaccinated mothers. An observational study was done in the gynecology department of a tertiary care hospital in Trivandrum from November 2022 to April 2023 (6 months duration) with 40 cord blood samples taken from completely vaccinated mothers. A total of 40 women were included who had completed two doses of Covishield vaccine. Presence of umbilical cord blood IgG was found in all the 40 samples, i.e. Covid IgG &#62; 17.8 BAU/mL. Among the 40 samples, 75% of them had not experienced any side effects after their vaccination while the remaining 25% had experienced minor side effects.The findings made from this study can be used to prove that vaccines are capable of producing antibodies in mother which will be transferred to her baby through the cord blood. It is also evident that the vaccine has produced only minor side effects.
Neuroprotective properties of GABA and its derivatives in diabetic encephalopathy in old animals
Authors: Tyurenkov I. N. , Bakulin D. A. , Smirnov A. V. , Ekova M. R. , Bisinbekova A. I. , Snigur G. L. , Velikorodnaya Yu. I. , Morkovin E. I. , Verkholyak D. V. , Vasilyeva O. S. 
Published: November 2023

The aimof the workwas to evaluate the GABA neuroprotective properties and its structural analogues in old animals after seven months of hyperglycemia.Materials and methods.Diabetes mellitus was modeled in white outbred male rats (12 months old) by the administration of a streptozotocin (65 mg/kg) and nicotinamide (230 mg/kg) combination. After 6 months, the animals with a postprandial glycemia level between 11 and 18 mmol/l were selected for the study. After the groups had been formed, the animals were administrated with GABA and GABAergic compounds (Compositions МРВАand PPC), respectively, for 1 month, the control group animals were administrated with saline. After the treatment, an oral glucose tolerance test and a set of behavioral tests aimed at studying sensory-motor (Open Field, Adhesion test, Rotarod) and cognitive functions (New Object Recognition and Morris Water Maze), as well as the functional state evaluation of the endothelium were performed. Further on, sampling of blood and brain tissues for a biochemical and enzyme immunoassay (the level of glucagon-like peptide-1 (GLP-1) and TNF-α in serum and the level of Klotho protein, BDNF, Nrf2, NF-κB and malondialdehyd (MDA) in brain homogenates), as well as a morphological analysis of changes in CA1 and CA3 neurons of the hippocampus and somatosensory cortex, was carried out.Results.GABA and compositions with its derivatives had a pronounced neuroprotective effect in old animals with prolonged hyperglycemia. The hypoglycemic effect of the studied compositions was accompanied by an increase in the production of GLP-1. In the animals with DM, after 6 weeks of the test substances administration, higher rates of sensory-motor and cognitive functions and a less structural damage to the sensory-motor cortex and the brain hippocampus were recorded. These effects may be due to higher levels of the Klotho proteins, Nrf2 and BDNF, as well as lower levels of NF-κB, which may underlie the suppression of the oxidative stress, the reduction of MDA and inflammation (TNF-α).Conclusion.After 6 weeks of the administration, GABA and its compositions in old animals (19 months old) significantly improved sensory-motor and cognitive functions, reduced negative structural changes in the hippocampus and somatosensory cerebral cortex.
Model for predicting risk of developing drug-induced liver injury during remdesivir therapy: observational prospective open case-control study
Authors: Shevchuk Yu. V. , Kryukov A. V. , Temirbulatov I. I. , Sychev I. V. , Mirzaev K. B. , Denisenko N. P. , Abdullaev Sh. P. , Tuchkova S. N. , Vechorko V. I. , Averkov O. V. , Sychev D. A. 
Published: November 2023

Remdesivir is a drug widely used for the etiotropic treatment of COVID-19. According to a number of studies, the incidence of adverse reactions during remdesivir therapy reaches 66%, with the most common is an increase in liver function tests.The aim of the work was to study the influence of clinical, demographic and pharmacogenetic factors on the development of drug-induced liver damage during remdesivir therapy in COVID-19 patients.Materials and methods. The study comprised 100 hospitalized patients treated with remdesivir. The patients were divided into two groups: group 1 (n=32) – remdesivir therapy, developed an increase in the level of liver transaminases; group 2 (control, n=68) – did not develop this adverse reaction. The patients in both groups underwent a pharmacogenetic study, and a retrospective analysis of medical records was performed. Based on the data obtained, the association of clinical, laboratory, pharmacological and pharmacogenetic parameters with the development of drug-induced liver damage during remdesivir therapy was studied.Results. In the group of patients with the development of drug-induced liver damage, people with a high body mass index were significantly more likely than in the control group (30.7±4.2 kg/m2 in group 1 vs. 27.3±5.5 kg/m2 in group 2, p=0.003), with a history of diabetes mellitus (odds ratio (OR)=2.647, 95% confidence interval (CI)=1.092–6.414, χ2=4.785, p=0.029), with higher levels of ferritin in the blood (724.03±432.27 and 553.19±358.48 mg/mol, respectively, p=0.040), receiving therapy with angiotensin-converting enzyme inhibitors (OR=5.440, 95% CI=2.160–13.699, χ2=14.027, p=0.000), statins (OR=3.148, 95% CI=1.307–7.581, χ2=6.795, p=0.009), and also being heterozygous for the polymorphic marker rs776746 of the CYP3A5 gene (OR=3.961, 95% CI=1.343–11.686, χ2=6.772, p=0.009).Conclusion. A high body mass index, a history of diabetes mellitus, high levels of ferritin in the blood, concomitant therapy with angiotensin-converting enzyme inhibitors and statins, as well as a carriage of the AG genotype for the polymorphic marker rs776746 of the CYP3A5 gene increase the likelihood of developing drug-induced liver damage during remdesivir therapy. In this regard, it is necessary to consider these factors when prescribing remdesivir therapy, conduct a more careful monitoring of clinical and laboratory indicators of liver damage, and develop personalized approaches to the treatment of COVID-19 patients.
ELASTISITAS SYARIâ€™AT ISLAM DALAM PERUBAHAN SOSIAL
Authors: Syaripuddin Said 
Published: November 2023

Penelitian ini bertujuan untuk menguji fleksibilitas hukum Islam di tengah-tengah perubahan sosial, berupaya untuk menggambarkan sifat komprehensif dan karakter teks hukum Islam dan menganalisis faktorfaktor syariah yang memiliki relevansi untuk perubahan sosial. Tulisan ini merupakan penelitian deskriptif kualitatif dengan menggunakan pendekatan multidisiplin termasuk pendekatan yuridis normatif, asas manfaat, dan pendekatan sosiologis. Studi ini menunjukkan bahwa isi teks syariah inklusif sehingga memungkinkan untuk ditafsirkankembali. Ada beberapa faktor yang menyebabkan Syariah menjadi dinamis dan relevan untuk beradaptasi dalam lingkungan baru. Pertama, ada sejumlah isu syariah yang tidak dijelaskan pada status hukumnya. Kedua, pada umumnya teks syari'ah menjelaskan semuamasalah. Ketiga, teks-teks syariah umumnya memiliki banyak "multitafsir". Keempat, hukum Islam mengakui kondisi darurat dan force majeure (istisnaâ€™) sebagai pengecualian hukum. Kelima, hukum Islam bersifat elastis, materi dapat diubah tergantung pada waktu, tempat, dan situasi. Oleh karena itu, pemahaman teks syari'ah harus terus dipertahankan dengan memperhatikan lingkungan di mana mujitahid hidup. Jadi mujtahid dapat menguraikan berbagai penafsiran teks syariâ€™ah sebagai akibat dari pengaruh yang mereka terima baik dari aspek waktu maupun lingkungan.
PERLINDUNGAN HUKUM BAGI NASABAH DALAM AKAD PEMBIAYAAN DI PEGADAIAN SYARIAH
Authors: Hidayatulloh  
Published: November 2023

Pegadaian syariah merupakan salah satu dari Industri Keuangan Non Bank yang mendapatkan perhatian besar dari masyarakat Indonesia. Data Otoritas Jasa Keuangan Tahun 2010-2014 disampaikan ke publik menunjukkan bahwa terjadi peningkatan jumah aset yang pesat di industri pegadaian syariah. Pada tahun 2014 tercatat asetnya mencapai Rp3.304.260.000 (Tiga Milyar Tiga Ratus Empat Juta dua Ratus Enam Puluh Ribu Rupiah). Kemudahan mendapatkan pinjaman dana untuk kebutuhan yang cepat menjadi salah satu alasan mengapa nasabah memiliki minat tinggi untuk bertransaksi di pegadaian syariah. Namun pegadaian syariah tidak lepas dari kritik, antara lain kegiatan usaha yang mirip dengan kredit di pegadaian konvensional dan perlindungan hukum bagi nasabah pembiayaan. dengan metode penelitian hukum normatif, penelitian ini menjawab beberapa persoalan penerapan prinsip syariah dan perlindungan hukum bagi nasabah berdasarkan peraturan perundang-undangan dan perspektif fikih. Penelitian ini menggunakan pendekatan konseptual (conceptual approach) dalam menguji data sekunder yang digunakan dan menganalisis secara kualitatif yang lebih mengutamakan kualitas data daripada kuantitasnya. Pada akhirnya, penelitian ini mengemukakan bahwa operasional pegadaian syariah di Indonesia telah sesuai dengan prinsip syariah dan perlindungan hukumbagi nasabahnya telah diatur dalam peraturan perundang-undangan khususnya Undang-Undang Nomor 8 Tahun 1999 tentang Perlindungan Konsumen, Peraturan Otoritas Jasa Keuangan Nomor: 1/POJK.07/2013 tentang Perlindungan Konsumen Sektor Jasa Keuangan. Adapun dengan konsep Himayah al-Mustahlik, Islam telah memberikan perhatian yang sangat besar terhadap perlindungan hukum bagi nasabah sesuai dengan maqashid syariah.
Some Notes on Andrápolis, the Royal City: Apocryphal Acts of Thomas 3
Authors: Muñoz Gallarte Israel , Narro Ángel 
Published: November 2023

The following paper aims to explore the meaning and significance of the so-called royal city Andrapolis (Ἀνδράπολις) within the context of the Apocryphal Acts of Thomas’s narrative (chapter 3). The identification of this Indian toponym have attracted the attention of many scholars during the last century and nowadays again, as witness of the few reliable historical traces supposedly transmitted by the apocryphal. For doing so, after a short introduction, we deal with the allegedly historicity of the text; then, we focus on the issue related mainly to the different variants of the location depending on the Syriac and Greek versions of the Acts of Thomas, and propose a new interpretation; finally, we check the rest of Greek variants among the manuscripts - collated by Bonnet and new findings -, trying to find the cause of their differences with the best attested Andrapolis, and draw some final remarks.
JOCRISE Paradigm, Methodology & Economics
Authors: Shakespeare Rodney , Mouatt Simon , Challen Peter 
Published: November 2023

JOCRISE is embarked upon a project of universal, even cosmic, significance.
Rejecting the outdated, inaccurate and static understanding of reality which underlies mainstream economics, the Paradigm provides a new, accurate and dynamic understanding of our changing world.
The new understanding is not reductionist and encompasses many subjects (including history, sociology, psychology, religion, environment, anthropology, technology and epistemology). The result is an ability to find solutions for major global problems (e.g., persistent poverty, depletion of resources and environmental depredation) which, at present, appear to be insoluble.
The Paradigm’s potency is comparable to that of the Copernican Revolution which overthrew the concept of an Earth-centred universe and replaced it by a sun-centred one with consequences including today’s political democracy (i.e., the vote) as well as modern astronomy and rocketry.
Just as the Revolution introduced a new methodology for astronomy, so the Paradigm introduces a new Methodology for economics which:-

establishes that mainstream economics is founded upon fifty nine false, outdated, interconnected assumptions about reality
reverses the false assumptions whereon the reversals (or opposites) are easily seen to be true and can therefore form the components of the new Economics with hugely beneficial consequences.

The ‘Great Reset’ is a phrase describing the proposals of the World Economic Forum which will concentrate all economic power into the hands of the few rather than putting economic power into the hands of the many.
The Paradigm has areas needing development (see Appendix Two). Readers are encouraged to make the development and so forward the progress of the Paradigm as a whole.
Margaret Archer (1943-2023) on Critical Realism and Morphogenesis: Linking Critical Realist Research Models from East and West
Authors: Adam-Bagley Chris , Abubaker Mahmoud 
Published: November 2023

Critical Realism (CR) is a philosophical approach to social science research, social action, and social change activism. It provides a framework for social scientists whose value commitments leads them to view the construction of social phenomenon in critical ways, which identify the often hidden oppressive elements in social structures. This understanding of a ‘new’ reality underlies the advocacy of change strategies, and the initiation of dialogue between members of disadvantaged and oppressed groups through the process of ‘morphogenesis’ This model of dialogues enabling change and the ‘unmasking of alienation’ stem from the work of Roy Bhaskar, and has been developed by Margaret Archer and other European scholars. An important feature of CR has been the application by the emergence of shared understanding, by social scientists from different value traditions (e.g. Christianity, Secular Humanism, and Islam). The JOCRISE in taking CR understandings of oppressive social forces into new fields, and with fresh CR models, is welcomed. In appraising the new model from JOCRISE, we offer both Cartesian dualism, and Popper’s World 3 model as elements of a new, dynamic focus on social change advocacy.
The Impact of Anthropometric Measurements on Radiotherapy Planning for Breast Cancer Patients
Authors: Koca Timur , Sengun Yasemin , Atak Ece , Aksu Melek Gamze , Tuncel Nina , Korcum Aylin Fidan 
Published: November 2023

Abstract
Background: It was aimed to evaluate the differences and relationship between the anthropometric characteristics of the patients who received radiotherapy in our clinic after breast-conserving surgery due to breast cancer. Methods: A total of 40 patients underwent whole breast and lymph node irradiation after breast-conserving surgery were evaluated according to dosimetric parameters and ​anthropometric variables such as weight, mid-sternum thickness, Haller index, central lung distance (CLD) and breast volume.Results: In internal mammary node (IMN) irradiated patients, lung doses (V5, V10, V20, V30, minimum dose (Dmin) and maximum dose (Dmax)) and contralateral breast doses (Dmax and V5) were significantly higher than the patients not received IMN irradiation. Also, breast size shown to be an important factor; when small and large breast sized patients were compared, ipsilateral lung V10, V20, and V30 values and the Dmin of heart were higher in patients with large breast volume. The V5 value and Dmin of the total lung were higher in the group with a CLD value of 3 cm or less. The contralateral breast Dmax and V5 doses were higher in patients with midsternum thickness above 1.7.Conclusions: In the radiotherapy of breast cancer especially for the patients with nodal treatment volumes, differences in treatment designs could be made according to anthropometric variables. In the evaluation of radiotherapy treatment plans individual features like chest wall shape and breast size should be kept in mind.
The comparison of diagnostic ability between blue laser/light imaging and narrow band imaging for sessile serrated lesions with or without dysplasia
Authors: Kobayashi Reo , Yoshida Naohisa , Morinaga Yukiko , Hashimoto Hikaru , Tomita Yuri , Inoue Ken , Hirose Ryohei , Dohi Osamu , Murakami Takaaki , Inada Yutaka , Morimoto Yasutaka , Itoh Yoshito 
Published: November 2023

Abstract
Objectives: Diagnostic ability of sessile serrated lesions (SSL) and SSL with dysplasia (SSLD) using blue laser/light imaging (BLI) has not been well examined. We analyzed the diagnostic accuracy of BLI for SSL and SSLD using several endoscopic findings compared to those of narrow band imaging (NBI).
Materials and Methods: This was a subgroup analysis of prospective studies. 476 suspiciously serrated lesions of ≥2 mm on the proximal colon showing serrated change with magnified NBI or BLI in our institution between 2014 and 2021 were examined histopathologically. After propensity score matching, we evaluated the diagnostic ability of SSL and SSLD of the NBI and BLI groups regarding various endoscopic findings. For WLI findings, granule, depression, reddish were examined for diagnosing SSLD. For NBI/BLI findings, expanded crypt opening (ECO) or thick and branched vessels (TBV) were examined for diagnosing SSL. Network vessels (NV) and white dendritic change (WDC) defined originally were examined for diagnosing SSLD.
Results: Among matched 176 lesions, the sensitivity of lesions with either ECO or TBV for SSL in the NBI/BLI group were 97.5%/98.5% (p=0.668). Those with either WDC or NV for diagnosing SSLD in the groups were 81.0%/88.9% (p=0.667). Regarding the rates of endoscopic findings among 30 SSLD and 290 SSL, there were significant differences in WDC (66.4% vs. 8.6%, p<0.001), NV (55.3% vs. 1.4%, p<0.001), and either WDC or NV (86.8% vs. 9.0%, p<0.001).
Conclusions: The diagnostic ability of BLI for SSL and SSLD was not different from NBI. NV and WDC were useful for diagnosing SSLD.
Assessment of rainfall-runoff process using Arc-GIS and HEC-HMS in Gelana Watershed, Rift Valley basin Ethiopia.
Authors: DIRIBA BERNABAS TESFAYE 
Published: November 2023

Abstract
Estimating runoff from rainfall is necessary to know the amount of water available in a river basin and to better understand the occurrence of flooding. In different basins, hydrological models have been used to determine hydrological processes and available water resources. This study investigates the use of distributed hydrological models to estimate rainfall-runoff processes in the Gelana River basin in West Guji Region,Ethiopia. The hydrological model HEC-HMS (Hydrologic Engineering Center, HydrologicalModeling System) is used in conjunction with the geospatial hydrological model extension, HEC-GeoHMS in the ArcGIS environment. DEMs (Digital Elevation Models)of the study areas were processed using HEC-GeoHMS, an ArcView GIS extension for watershed delineation, terrain preprocessing, and watershed processing was used to estimate the HEC-HMS continuous rainfall runoff simulation. The meteorological models were developed within the HEC-HMS from the recorded daily rainfall data for the hydrological years 2000 to 2010. In HEC-HMS, the basin model includesthree important processes; loss, conversion and basic flow. The control specifications have been defined for the specified time period and time step within a day. Soil conservation service curvenumber (SCS-CN), SCS unit hydrology method, and Muskingum methodwere used to calculate losses, conversion,and routing, respectively. For model calibration the coefficient of determination, Nash-Sutcliffe coefficient, and PBIAS resulted in 0.75, 0.72 and 3.4 respectively for calibration and 0.79, 0.77 and -7 respectively for validation. The results indicate that HEC-HMS can be used for the hydrological modeling of the watershed which will be necessary for soil and water conservation of the area.
Contractile injection systems facilitate sporogenic differentiation of bacteria through the action of a phage tapemeasure protein-related effector.
Authors: Nagakubo Toshiki , Nishiyama Tatsuya , Yamamoto Tatsuya , Nomura Nobuhiko , Toyofuku Masanori 
Published: November 2023

Abstract

Contractile injection systems (CISs) are prokaryotic phage tail-like nanostructures loading effector proteins that mediate various biological processes. Although CIS functions have been diversified through evolution and hold the great potential as protein delivery systems, the functional characterisation of CISs and their effectors is currently limited to a few CIS lineages. Here, we show that the CISs of Streptomyces davawensis belong to a unique group of bacterial CISs distributed across distant phyla and facilitate sporogenic differentiation of this bacterium. CIS loss results in decreased extracellular DNA release, biomass accumulation, and spore formation in S. davawensis. CISs load an effector, which is a remote homolog of phage tapemeasure proteins, and its C-terminal domain has endonuclease activity responsible for the CIS-associated phenotypes. Our findings illustrate that CISs can contribute to the reproduction of bacteria through the action of the effector and suggest an evolutionary link between CIS effectors and viral cargos.