bluuebunny/crossref_metadata_2025_split huggingface dataset:
Вплив екстракту трави Tagetes Patula L. на морфоструктурні зміни підшлункової залози за умов експериментального стрептозотоцин- індукованого ураження
Authors: Цубанова Н. А. , Волощук Н. І. , Галевич Г. Б. 
Published: December 2023

Ураження підшлункової залози лікарськими препаратами реєструють з кожним роком усе частіше. Перспективним об’єктом для зниження токсичної дії деяких лікарських засобів на підшлункову залозу можна вважати лікарську рослинну сировину з антиоксидантною та цитопротекторною дією.
Мета дослідження – оцінити вплив екстракту трави чорнобривців розлогих Tagetes Patula L. (ЕТЧР) на гістоструктуру підшлункової залози за експериментального стрептозотоцинового ураження.
Експериментальне ураження стрептозотоцином моделювали його одноразовим внутрішньоочеревинним введенням щурам масою 180–220 г у дозі 55 мг/кг. Досліджуваний cухий ЕТЧР вводили внутрішньошлунково в дозі 25 мг/кг у лікувально-профілактичному режимі.
Встановлено, що за умов експериментального стрептозотоцинового ураження підшлункової залози ЕТЧР чинить потужну органопротекторну дію, про що свідчить позитивна динаміка структурних змін в острівцевому апараті підшлункової залози щурів, зменшення деструктивно-дистрофічно змінених і збільшення функціонально повноцінних інсуліноцитів. Досліджений екстракт проявляє протизапальну дію, виразно знижуючи ознаки інсуліту та запальної реакції в міжацинарній тканині. Морфометрично в мікропрепаратах групи тварин, які отримували ЕТЧР, порівняно з нелікованими тваринами виявлено збільшення кількості панкреатичних острівців, вмісту бета-клітин та альфа-клітин, а також збільшення функціонального індексу та відновлення відсоткового розподілу острівців за класами.
Таким чином, за умов експериментального ураження стрептозотоцином, введення ЕЧТР у лікувально-профілактичному режимі в дозі 25 мг/кг внутрішньошлунково чинить захисний вплив на інсулярний апарат підшлункової залози.
Корекція фармакопейної пробопідготовки визначення вмісту цинку в активованому вугіллі методом атомно-емісійної спектрометрії з індуктивно зв’язаною плазмою
Authors: Брицун В. М. , Останіна Н. В. 
Published: December 2023

Мета дослідження – корекція пробопідготовки фармакопейної методики визначення вмісту цинку (Zn) методом атомної спектрометрії з індуктивно зв’язаною плазмою (ІЗП-АЕС) в активованому вугіллі (фармацевтичній сировині) з урахуванням забруднення Zn скляного посуду, фільтрів і т. п., розробка та апробація альтернативної методики переводу Zn у розчин.

Пробопідготовку для вимірювання вмісту Zn проводили двома способами: фармакопейна методика (екстракція Zn з активованого вугілля 0,1 моль/л хлористоводневою кислотою) та альтернативна (спалювання наважки активованого вугілля в порцеляновому тиглі та розчинення залишку в 0,1 моль/л хлористоводневій кислоті). Після чого методом ІЗП-АЕС на оптико-емісійному спектрометрі з індуктивно зв’язаною плазмою Agilent 5800 ICP-OES на довжині хвилі Zn 213,857 нм знаходили концентрацію Zn у випробовувальних розчинах і обчислювали його вміст в активованому вугіллі.
Для дослідження було використано зразок вугілля активованого (здрібненість – 97 % часток з розміром не більше ніж 0,2 мм). Для приготування розчинів використовували хлористоводневу кислоту 33,6 % (Honeywell, TraceSelect Ultra for ultratrace analysis). Стандартні розчини були приготовле- ні зі стандартів ICP-OES Wavelenghth Calibration Solution фірми «Agilent Technologies» розведенням до потрібних концентрацій у полімерному посуді. Вода деіонізована була отримана з системи Millipore Direct-Q 3 UV. Фільтрувальний папір виробництва Whatman і Yancheng Jingwei Intl Co. Ltd.
Згідно з отриманими результатами, концентрація Zn, який унаслідок пробопідготовки як домішка потрапив до аналіту, складає 61,3–1012,5 мкг/кг (0,25–4,05 % від вимог ДФУ). Визначення вмісту Zn в активованому вугіллі за фармакопейною пробопідготовкою дало результат 2065,8 мкг/кг (невизначеність ± 72,7 мкг/кг, тобто концентрація Zn у межах 1993,1–2138,5 мкг/кг). Для запропонованої нами методики – концентрація Zn 2113,8 мкг/кг, тобто в межах невизначеності результатів фармакопейної методики.
Таким чином, при визначенні вмісту Zn в активованому вугіллі (фармацевтичній сировині) за фар- макопейною методикою слід обов’язково робити холостий дослід, щоб враховувати наявність Zn в скляному посуді, на фільтрах, на руках експериментатора. Уміст «стороннього» Zn, згідно з отрима- ними експериментальними даними, складає 0,25–4,05 % від вимог Державної Фармакопеї України. Пробопідготовка визначення Zn може бути проведена альтернативним шляхом: спалюванням наважки активованого вугілля в порцеляновому тиглі з наступною екстракцією сполук Zn 0,1 моль/л хлористоводневою кислотою. Дані, що отримані за альтернативною методикою, добре узгоджуються з результатами визначення за фармакопейною методикою.
Modalidades de control interno y su efectividad contra la corrupción en municipalidades ejercicio 2022
Authors: Vélez Arana José Sócrates 
Published: December 2023

La presente investigación tuvo como objetivo general, analizar la influencia de las modalidades de control interno en la efectividad contra la Corrupción en municipalidades ejercicio 2022.
El estudio que corresponde a esta investigación por el propósito y finalidad fue básica, por la naturaleza de los datos tiene un enfoque cualitativo, y correspondió a un estudio de caso. La categoría analizada fue Modalidades de control interno, y como sub categorías se evaluó el control simultaneo y el control posterior. El escenario corresponde al ámbito de Lima Metropolitana donde laboran los participantes que fueron auditores con más de 10 años de experiencia en auditoria gubernamental. Para la recolección de información se usó una entrevista. Como resultado de procesar las respuestas del grupo de auditores en el software Atlas ti, se obtuvo la siguiente idea en base al enraizamiento de los códigos: “La escasa rendición de cuentas, y la pobre experiencia laboral, conducen a una baja eficiencia municipal, alentado por una nula opinión gubernamental, lo cual eleva el grado de corrupción”. Se concluyó que el control simultaneo como modalidad de Control interno en municipalidades tiene un mayor impacto en la lucha contra la corrupción, y que el control posterior cuando es consecuencia de la aplicación del control simultaneo es más efectivo.
The myth of aortic valve annulus changes in aortic valve disease
Authors: Peng Yanren , Hu Huijun , Shu Xiaorong , Lin Yongqing , Huang Weibin , Xu Shuwan , Nie Ruqiong 
Published: December 2023

BackgroundThe characteristics of aortic annulus changes in aortic regurgitation (AR) patients are poorly understood, and predictive factors among aortic valve disease are yet to be established.ObjectiveThis study seeks to elucidate the pattern of annular size fluctuations across different cardiac phases in AR patients and to identify predictors for annular enlargement during either systole or diastole in aortic valve diseases.MethodsA retrospective analysis was conducted on 55 patients with severe aortic valve diseases, including 26 patients with aortic stenosis (AS) and 29 with AR, to discern the two groups' contrasting and analogous patterns of annular changes. The patient sample was expanded to 107 to investigate the factors influencing the size of the annulus during different cardiac phases. Based on our findings, patients were then divided into two groups: those with an annulus that is larger during systole (83 patients) and those where the annulus is larger during diastole (24 patients).ResultsTypically, AR patients exhibit a dynamic annulus, with both perimeter and area being largest during mid-systole. These dimensions diminish progressively and then increase again in early diastole, a pattern consistent with observations in AS patients. Among 107 patients, 21% had diastolic enlargement. Systolic measurements would lead to prosthesis undersizing in 17% of these. Male gender and lower systolic annulus minimum relative to body surface area (AnMin index) were predictors of diastolic enlargement, with ROC curve areas of 0.70 and 0.87 for AR and AS, respectively.ConclusionsSystolic measurements are recommended for AR patients. Gender and the AnMin index are significant predictors, particularly potent in AS patients.
Association between cumulative uric acid to high-density lipoprotein cholesterol ratio and the incidence and progression of chronic kidney disease
Authors: Liu Peipei , Li Junjuan , Yang Ling , Zhang Zihao , Zhao Hua , Zhao Naihui , Ou Wenli , Zhang Yinggen , Chen Shuohua , Wang Guodong , Zhang Xiaofu , Wu Shouling , Yang Xiuhong 
Published: December 2023

ObjectiveThe ratio of uric acid to high-density lipoprotein cholesterol (UHR) was related to the risk of chronic kidney disease (CKD), we aimed to investigate the association of cumulative UHR (cumUHR) with incidence and progression of CKD.MethodsOur study included a total of 49,913 participants (mean age 52.57 years, 77% males) from the Kailuan Study conducted between 2006 and 2018. Participants who completed three consecutive physical examinations were included. Cumulative UHR (cumUHR) was computed as the summed average UHR between two consecutive physical examinations, multiplied by the time between the two examinations. Participants were then categorized into four groups based on cumUHR quartiles. Subsequently, participants were further divided into a CKD group and a non-CKD group. The associations between cumUHR and CKD and it’s progression were assessed by Cox proportional hazards regression models. The cumulative incidence of endpoint events was compared between the cumUHR groups using the log-rank test. The C-index, net reclassification improvement (NRI) and integrated discrimination improvement (IDI) were calculated to assess the predictive performance of cumUHR.ResultsAfter a mean follow-up of 8.0 ± 1.7 years, there were 4843 cases of new-onset CKD, 2504 of low eGFR, and 2617 of proteinuria in the non-CKD group. Within the CKD group, there were 1952 cases of decline in eGFR category, 1465 of &gt;30% decline in eGFR, and 2100 of increased proteinuria. In the non-CKD group, the adjusted hazard ratios (HRs) and confidence intervals (CIs) in the fourth quartile were 1.484 (1.362–1.617), 1.643 (1.457–1.852), and 1.324 (1.179–1.486) for new-onset CKD, low eGFR, and proteinuria, respectively. In the CKD group, the adjusted HRs in the fourth quartile were 1.337 (1.164–1.534), 1.428 (1.216–1.677), and 1.446 (1.267–1.651) for decline in eGFR category, &gt;30% decline in eGFR, and increase in proteinuria, respectively. In addition, we separately added a single UHR measurement and cumUHR to the CKD base prediction model and the CKD progression base prediction model, and found that the models added cumUHR had the highest predictive value.ConclusionHigh cumUHR exposure was an independent risk factor for the incidence and progression of CKD, and it was a better predictor than a single UHR measurement.
Oil/water separation by super-hydrophobic wastepaper cellulose-candelilla wax cryogel: a circular material-based alternative
Authors: Romero-Montero A. , Rosas-Melendez S. A. , Valencia-Bermúdez J. L. , Nuñez-Tapia I. , Piña-Barba M. C. , Melgoza-Ramírez L. J. , Leyva-Gómez G. , Del Prado-Audelo M. L. 
Published: December 2023

Introduction: One of the most attractive fields for cellulose aerogels is water remediation, basically in the pollutant’s adsorption and oil/water separation. There are different sources to extract cellulose, but the extraction from paper waste is an excellent option for impulse circular materials applications.Methods: We obtained cellulose from office waste paper through a simple alkali method and used it to fabricate an aerogel by freeze-drying based on the materials’ circularity. To increase lipophilicity, the aerogel was modified using two different coatings: polycaprolactone (WOPP) and candelilla wax (WOPW), extracted from a Mexican plant. The aerogels were analyzed by several physicochemical techniques such as Scanning Electronic Microscopy, Infrared spectroscopy, and thermal analysis.Results and Discussion: To our knowledge, this is the first time that candelilla wax has been reported as aerogel modification. The highly porous aerogels showed a density of around 0.1 g/cm3 and a fibrous structure. Furthermore, the contact angle of the aerogels was measured to compare the hydrophobicity of the surfaces, showing values around 120° in the modified aerogels compared with the hydrophilic behavior of pristine cellulose aerogel. The achieved recycled mineral oil absorption capacity for WOPW was 6.1 g/g, while for WOPP was 4.88 g/g. Thus, we obtained a natural coating aerogel with a high water/oil separation potential.
Fluid homeostatic action of dapagliflozin in patients with chronic kidney disease: the DAPA-BODY Trial
Authors: Oka Kentaro , Masuda Takahiro , Ohara Ken , Miura Marina , Morinari Masato , Misawa Kyohei , Miyazawa Yasuharu , Akimoto Tetsu , Shimada Kazuyuki , Nagata Daisuke 
Published: December 2023

Sodium glucose cotransporter 2 (SGLT2) inhibitors have both glucose-lowering and diuretic effects. We recently reported that the SGLT2 inhibitor dapagliflozin exerts short-term fluid homeostatic action in patients with chronic kidney disease (CKD). However, the long-term effects of SGLT2 inhibitors on body fluid status in patients with CKD remain unclear. This was a prospective, non-randomized, open-label study that included a dapagliflozin treatment group (n = 73) and a control group (n = 24) who were followed for 6 months. Body fluid volume was measured using a bioimpedance analysis device. The extracellular water-to-total body water ratio (ECW/TBW), a predictor of renal outcomes, was used as a parameter for body fluid status (fluid retention, 0.400 ≤ ECW/TBW). Six-month treatment with dapagliflozin significantly decreased ECW/TBW compared with the control group (−0.65% ± 2.03% vs. 0.97% ± 2.49%, p = 0.0018). Furthermore, dapagliflozin decreased the ECW/TBW in patients with baseline fluid retention, but not in patients without baseline fluid retention (−1.47% ± 1.93% vs. −0.01% ± 1.88%, p = 0.0017). Vasopressin surrogate marker copeptin levels were similar between the control and dapagliflozin groups at 6 months (32.3 ± 33.4 vs. 30.6 ± 30.1 pmol/L, p = 0.8227). However, dapagliflozin significantly increased the change in copeptin levels at 1 week (39.0% ± 41.6%, p = 0.0010), suggesting a compensatory increase in vasopressin secretion to prevent hypovolemia. Renin and aldosterone levels were similar between the control and dapagliflozin groups at 6 months, while epinephrine and norepinephrine (markers of sympathetic nervous system activity) were significantly lower in the dapagliflozin group than in the control group. In conclusion, the SGLT2 inhibitor dapagliflozin ameliorated fluid retention and maintained euvolemic fluid status in patients with CKD, suggesting that SGLT2 inhibitors exert sustained fluid homeostatic actions in patients with various fluid backgrounds.Clinical trial registration: https://www.umin.ac.jp/ctr/, identifier [UMIN000048568].
Correlates of physical activity levels, muscle strength, working memory, and cognitive function in older adults
Authors: Li Shufan , Wang Peng , Cai Zhidong , Jiang Wanting , Xin Xin , Wang Xing , Zhou Xiaojing 
Published: December 2023

ObjectiveTo explore the relationship between physical activity level, muscle strength, working memory and cognitive function in older adults.MethodsA cross-sectional research design was employed to recruit 120 older adults individuals aged 70 and above. Participants were asked to complete the International Physical Activity Questionnaire-Short Form and the Montreal Cognitive Assessment Scale. Data on variables such as grip strength and performance on the N-back task were collected. Data analysis involved the use of independent samples t-tests, χ2 tests, linear regression analysis, Pearson correlation analysis, and one-way analysis of variance (ANOVA).ResultsThe detection rate of cognitive dysfunction in older adults was 53.211%; 1-back correct rate had an explanatory power of 11.6% for the cognitive function scores of older adults (R2 = 0.116, p &lt; 0.001); grip strength showed a significant positive correlation with 1-back correct rate (r = 0.417, p &lt; 0.001), and was significantly correlated with the 0-back response time (r = −0.478), 1 -back response time (r = −0.441) were significantly negatively correlated (p &lt; 0.001); physical activity level was significantly positively correlated with grip strength (r = 0.559, p &lt; 0.001), and the difference in grip strength among older adults with different physical activity levels was statistically significant (F = 19.685, p &lt; 0.001).ConclusionPhysical activity level, muscle strength, working memory, and cognitive function are closely related in older adults, and the relational pathway of physical activity → muscle strength → working memory → cognitive function may serve as a useful addition to promote the field of cognitive research in older adults. To identify and prevent cognitive decline in older adults, physical activity questionnaires, grip strength tests, and 1-back task tests can be extended to nursing homes and communities.
Serum neurofilament light chain levels in patients with cognitive deficits and movement disorders: comparison of cerebrospinal and serum neurofilament light chain levels with other biomarkers
Authors: Novobilský Richard , Bartova Petra , Lichá Karin , Bar Michal , Stejskal David , Kusnierova Pavlína 
Published: December 2023

BackgroundSerum neurofilament light chain (S NfL) is a non-specific marker of neuronal damage, including Alzheimer’s disease (AD). We aimed to verify the reference interval (RI) of serum NfL using a highly sensitive ELISA, and to estimate the optimal cut-off value for neuronal damage. Our second objective was to compare NfL in cerebrospinal fluid (CSF) and serum (S) with the routine neurodegeneration biomarkers used in AD, and to assess their concentrations relative to the degree of cognitive deficit.MethodsSamples from 124 healthy volunteers were used to estimate the S NfL RI. For the comparison study, we used CSF and S samples from 112 patients with cognitive disorders. Cognitive functions were assessed using the mini-mental state examination. ELISA assays were used to determine the CSF and S NfL levels, CSF β-amyloid peptide42 (Aβ42), CSF β-amyloid peptide40 (Aβ40), CSF total tau protein (tTau), CSF phosphorylated tau protein (pTau), and CSF alpha-synuclein (αS).ResultsThe estimated RI of S NfL were 2.25–9.19 ng.L–1. The cut-off value of S NfL for assessing the degree of neuronal impairment was 10.5 ng.L–1. We found a moderate statistically significant correlation between S NfL and CSF Aβ42 in the group with movement disorders, without dementia (rs = 0.631; p = 0.016); between S NfL and CSF Aβ40 in the group with movement disorder plus dementia (rs = −0.750; p = 0.052); between S NfL and CSF tTau in the control group (rs = 0.689; p = 0.009); and between S NfL and CSF pTau in the control group (rs = 0.749; p = 0.003). The non-parametric Kruskal–Wallis test revealed statistically significant differences between S NfL, CSF NfL, CSF Aβ42, CSF tTau, and CSF pTau and diagnosis within groups. The highest kappa coefficients were found between the concentrations of S NfL and CSF NfL (κ = 0.480) and between CSF NfL and CSF tTau (κ = 0.351).ConclusionOur results suggested that NfL and tTau in CSF of patients with cognitive decline could be replaced by the less-invasive determination of S NfL using a highly sensitive ELISA method. S NfL reflected the severity of cognitive deficits assessed by mini-mental state examination (MMSE). However, S NfL is not specific to AD and does not appear to be a suitable biomarker for early diagnosis of AD.
Study on the influence mechanism of perceived benefits on unsafe behavioral decision-making based on ERPs and EROs
Authors: Zhang Shu , Yang Qiyu , Wei Cong , Shi Xiuzhi , Zhang Yan 
Published: December 2023

IntroductionPerceived benefits are considered one of the significant factors affecting an individual’s decision-making process. Our study aimed to explore the influence mechanism of perceived benefits in the decision-making process of unsafe behaviors.MethodsOur study used the “One Stimulus-Two Key Choice (S-K1/K2)” paradigm to conduct an EEG experiment. Participants (N = 18) made decisions in risky scenarios under high perceived benefits (HPB), low perceived benefits (LPB), and control conditions (CC). Time domain analysis and time-frequency analysis were applied to the recorded EEG data to extract ERPs (event-related potentials) and EROs (event-related oscillations), which include the P3 component, theta oscillations, alpha oscillations, and beta oscillations.ResultsUnder the HPB condition, the theta power in the central (p = 0.016*) and occipital regions (p = 0.006**) was significantly decreased compared to the CC. Similarly, the alpha power in the frontal (p = 0.022*), central (p = 0.037*), and occipital regions (p = 0.014*) was significantly reduced compared to the CC. Under the LPB condition, theta power in the frontal (p = 0.026*), central (p = 0.028*), and occipital regions (p = 0.010*) was significantly reduced compared to the CC. Conversely, alpha power in the frontal (p = 0.009**), central (p = 0.012*), and occipital regions (p = 0.040*) was significantly increased compared to the HPB condition.DiscussionThe high perceived benefits may reduce individuals’ internal attention and evoke individuals’ positive emotions and motivation, leading individuals to underestimate risks. Consequently, they exhibited a greater inclination toward unsafe behaviors. However, the low perceived benefits may reduce individuals’ memory review, resulting in a simple decision-making process, and they are more inclined to make fast decisions to avoid loss. The research results can help to provide targeted intervention measures, which are beneficial to reducing workers’ unsafe behaviors.
Machine learning-based model for predicting inpatient mortality in adults with traumatic brain injury: a systematic review and meta-analysis
Authors: Wu Zhe , Lai Jinqing , Huang Qiaomei , Lin Long , Lin Shu , Chen Xiangrong , Huang Yinqiong 
Published: December 2023

Background and objectivePredicting mortality from traumatic brain injury facilitates early data-driven treatment decisions. Machine learning has predicted mortality from traumatic brain injury in a growing number of studies, and the aim of this study was to conduct a meta-analysis of machine learning models in predicting mortality from traumatic brain injury.MethodsThis systematic review and meta-analysis included searches of PubMed, Web of Science and Embase from inception to June 2023, supplemented by manual searches of study references and review articles. Data were analyzed using Stata 16.0 software. This study is registered with PROSPERO (CRD2023440875).ResultsA total of 14 studies were included. The studies showed significant differences in the overall sample, model type and model validation. Predictive models performed well with a pooled AUC of 0.90 (95% CI: 0.87 to 0.92).ConclusionOverall, this study highlights the excellent predictive capabilities of machine learning models in determining mortality following traumatic brain injury. However, it is important to note that the optimal machine learning modeling approach has not yet been identified.Systematic review registrationhttps://www.crd.york.ac.uk/PROSPERO/display_record.php?RecordID=440875, identifier CRD2023440875.