bluuebunny/crossref_metadata_2025_split huggingface dataset:
Automatic deep learning method for third lumbar selection and body composition evaluation on CT scans of cancer patients
Authors: Delrieu Lidia , Blanc Damien , Bouhamama Amine , Reyal Fabien , Pilleul Frank , Racine Victor , Hamy Anne Sophie , Crochet Hugo , Marchal Timothée , Heudel Pierre Etienne 
Published: January 2024

IntroductionThe importance of body composition and sarcopenia is well-recognized in cancer patient outcomes and treatment tolerance, yet routine evaluations are rare due to their time-intensive nature. While CT scans provide accurate measurements, they depend on manual processes. We developed and validated a deep learning algorithm to automatically select and segment abdominal muscles [SM], visceral fat [VAT], and subcutaneous fat [SAT] on CT scans.Materials and MethodsA total of 352 CT scans were collected from two cancer centers. The detection of the third lumbar vertebra and three different body tissues (SM, VAT, and SAT) were annotated manually. The 5-fold cross-validation method was used to develop the algorithm and validate its performance on the training cohort. The results were validated on an external, independent group of CT scans.ResultsThe algorithm for automatic L3 slice selection had a mean absolute error of 4 mm for the internal validation dataset and 5.5 mm for the external validation dataset. The median DICE similarity coefficient for body composition was 0.94 for SM, 0.93 for VAT, and 0.86 for SAT in the internal validation dataset, whereas it was 0.93 for SM, 0.93 for VAT, and 0.85 for SAT in the external validation dataset. There were high correlation scores with sarcopenia metrics in both internal and external validation datasets.ConclusionsOur deep learning algorithm facilitates routine research use and could be integrated into electronic patient records, enhancing care through better monitoring and the incorporation of targeted supportive measures like exercise and nutrition.
Global research hotspots and trends in non-surgical treatment of adolescent idiopathic scoliosis over the past three decades: a bibliometric and visualization study
Authors: Xu Jie , Chen Meng , Wang Xin , Xu Lin , Luo Xiaobing 
Published: January 2024

BackgroundIn recent years, research on the non-surgical treatment of AIS has been increasingly conducted. To the best of our knowledge, this field doesn't yet have a comprehensive and structured pulse combing analysis. In order to provide inspiration and resources for subsequent researchers, we thus reviewed the literature studies on the non-surgical treatment of AIS from the previous thirty years and highlighted the hotspots and frontiers of research in this field.MethodsMain using Citespace 6.1 software, the data from the core dataset of the WOS database pertaining to the non-surgical management of AIS from 1990 to 2022 was gathered, displayed, and analyzed.Results839 papers in all were included in the literature. With 215 papers, the USA came in first place. Chinese Univ Hong Kong ranked first with 32 papers. Research hotspots are adolescent idiopathic spondylitis, Schroth-based physiotherapy-specific exercise efficacy, curve development, Cobb angle, TLSO brace-based clinical efficacy, quality of life, reliability, health-related quality of life questionnaires, finite element biomechanical models, follow-up, and clinical guidelines.ConclusionThere aren't many studies that compare the clinical effectiveness of various non-surgical treatments, and because of variations in inclusion eligibility standards and outcome measures, these studies cannot be directly compared. In addition, the inconsistency of existing growth potential and progression risk assessment systems further affects comparative studies of clinical efficacy; it is recommended to establish primary assessment indicators centered on patient treatment outcomes (including appearance, disability, pain, and quality of life), as well as standardized scoliosis progression risk assessment criteria.
Bioactivity and toxicity of coumarins from African medicinal plants
Authors: Anywar Godwin , Muhumuza Emmanuel 
Published: January 2024

Introduction: Coumarins are naturally occuring metabolites from plants and a few micro-organisms. They have been widely used in the food and drug industry in their natural or synthetic forms. Numerous coumarins possess several biological activities such as anti-inflammatory, anti-ulcers, anti-tumour, anti-microbial, anti-coagulant. The aim of this study was to assess the bioactivity, and toxicity of coumarins from African medicinal plants.Methods: We searched online databases and search engines such as PubMed, Google Scholar and Web of Science for key terms such as coumarins, toxicity, bioavailability, bioactivity with appropriate Boolean operators. Only full-length research articles published in English between 1956 to 2023 were reviewed.Results: We recorded 22 coumarins from 15 plant species from Africa. Most of the plant species (33%) were from North Africa. These were followed by East Africa at 21%, then West, and Central Africa at 18.2% each. Most of the coumarins (21.3%) were isolated from the entire plant and the leaves (19.1%) and most of them (46.7%) had some antimicrobial activity. Five coumarins viz osthole, pseudocordatolide C &amp; calanolide, chartreusin and esculetin had either antitumor or anticancer activity. Six coumarins had varying levels and types of toxicity ranging from inhibiting blood clotting as anticoagulants, to cytotoxic effects, causing hyperventilation, tremor, &amp; photophobia, pulmonary haemorrhage, carcinogenic activity, severe neurotoxicity, hepato- and phototoxicity.Conclusion: Several African medicinal plants are sources of various coumarins that possess several biological activities as well as toxicities. This calls for more research into their safety and efficacy because of their wide spread applications as therapeutic agents.
A bibliometric and visual analysis of the use of ustekinumab in Crohn’s disease using CiteSpace
Authors: Chen Yi , Zhang Jiaqi , Wu Junling , Zhang Hanwen , Luan Zhe , Zhao Zhizhuang , Li Congyong , Zhao Yiming , Zhang Hu , Wang Shufang , Sun Gang 
Published: January 2024

Background: The novel biologic agent ustekinumab (UST), a monoclonal antibody against the p40 subunit of interleukin-12 and interleukin-23, has been applied in the treatment of Crohn’s disease (CD). With the development of relevant research, the clinical treatment and favorable prognosis of UST in CD have garnered considerable attention. However, there is a lack of reports that present the current status of UST-related studies in a comprehensive and objective manner. Consequently, this study aims to visually analyze the current status and clinical trends of UST-related research, identify leading researchers, and recognize deficiencies using bibliometrics and knowledge mapping, which might assist in understanding future research priorities in that specific field.Methods: Published articles containing the use of UST in CD were retrieved from the Web of Science core collection database between 2008 and 2022. Then, the bibliometric analysis was performed, and a knowledge map was generated and visualized using the CiteSpace software.Results: A total of 479 articles published between 2008 and 2022 were included in the bibliometric analysis. These publications were authored by 185 scholars from 51 countries or regions, among which the United States (38.3%), Canada (16.9%) and England (10.0%) were predominant in publishing. The keyword analysis indicated that UST has long been a popular biologic agent, and its clinical efficacy, safety, and indication for vulnerable populations in CD are popular research topics. The phrase “fecal calprotectin,” a biomarker reflecting the degree of disease activity and monitoring the therapeutic response, began to gain traction in 2020 and has continued to this day. Looking for UST-related biomarkers was gaining clinical attention.Conclusion: The number of clinical studies involving the outcome of UST treatment in CD patients has increased, with the current research focusing on efficacy, safety, indications for vulnerable populations, therapeutic drug monitoring, and biomarkers. As an alternative drug after the failure of traditional immunosuppressive therapies or TNF-α antagonist therapy, UST is an effective and safe therapy in real-world refractory CD patients. UST will remain an active candidate for research in the treatment of CD.
Chinese translation and validation of the Near-Death Experience Content scale
Authors: Li Yan , Chen Yan , Martial Charlotte , Shen Mingquan , Cassol Héléna , Yu Jing , Zhou Xingyue , Ni Chengcheng , Li Meiqi , Hu Nantu , Gosseries Olivia , Laureys Steven , Di Haibo 
Published: January 2024

IntroductionIn recent years, a growing number of near-death experience (NDE) testimonies have been collected worldwide due to an increasing interest in research on this phenomenon. China has many patients who survive life-threatening situations, leaving over much data on NDEs to be collected for research. In the historical context of Eastern civilization, many mentally controlled practices in China can also lead to “NDEs-like” (e.g., meditation). This study aimed (1) to translate and validate the recently developed Near-Death Experience Content (NDE-C) scale into Chinese and (2) to quantify and identify NDEs and NDEs-like in China with this new Chinese version of the NDE-C scale.MethodsHere, we presented the work that had been performed to translate the NDE-C scale into Chinese and validated this version on 79 NDE testimonies.ResultsBrislin’s back-translation model was performed to translate a Chinese version of the NDE-C scale and internal consistency (the Cronbach’s α value for the total group = 0.846) as well as the confirmatory factor analysis was conducted.DiscussionCurrently, the Chinese version of the NDE-C scale is ready for use in research practice in the context of Eastern culture, to screen people who have experienced an NDEs(-like) and to quantify their subjective experience, promoting further NDEs-related research in China.
Prevalence and correlates of suicidal ideation in the general public during the fifth wave of COVID-19 pandemic in Hong Kong
Authors: Lo Heidi Ka Ying , Chan Joe Kwun Nam , Wong Corine Sau Man , Wong Gabbie Hou Sem , Lei Janet Hiu Ching , So Yuen Kiu , Fung Vivian Shi Cheng , Chu Ryan Sai Ting , Ling Rachel , Chung Albert Kar Kin , Lee Krystal Chi Kei , Cheng Calvin Pak Wing , Chan Wai Chi , Chang Wing Chung 
Published: January 2024

IntroductionLiterature reveals increased suicidal ideation in the general population during pandemic. However, few COVID-19 studies comprehensively assessed factors associated with suicidal ideation, and mixed findings were observed. We aimed to examine prevalence and correlates of suicidal ideation in general public during the peak of fifth COVID-19 wave in Hong Kong based on a broad array of relevant measures.MethodsThis survey assessed 14,709 community-dwelling adults during March 15–April 3, 2022. Comprehensive assessment was administered including socio-demographics, pre-existing mental/physical morbidity, mental-health symptoms, resilience, loneliness, coping strategies, and pandemic-related factors. Presence of suicidal ideation was evaluated by ratings of item 9 on Patient-Health-Questionnaire-9.ResultsA total of 2,249 (15.3%) participants exhibited suicidal ideation. Multivariable-regression analysis found that being single and unemployed, pre-existing mental disorder, more severe depressive and anxiety symptoms, higher levels of loneliness and engagement in avoidant coping were significantly associated with suicidal ideation. Conversely, attaining tertiary educational level or above, greater resilience and adopting problem-focused coping were associated with lower likelihood of suicidal ideation. Although univariate-analyses revealed that a number of pandemic-related factors were linked to suicidal ideation, none remained significant in the multivariable model.ConclusionA significant proportion of people experienced suicidal ideation during the peak of fifth COVID-19 wave. Risk and protective factors identified would facilitate early identification of high-risk individuals and provision of targeted interventions to minimize suicidal ideation and risk of self-harm. Caution should be exercised due to study limitations of a cross-sectional design which precluded establishing causality among variables, and reliance on self-reported data.
Association between systemic immune-inflammatory index and diabetes mellitus: mediation analysis involving obesity indicators in the NHANES
Authors: Chen Yongze , Huang Ruixian , Mai Zhenhua , Chen Hao , Zhang Jingjing , Zhao Le , Yang Zihua , Yu Haibing , Kong Danli , Ding Yuanlin 
Published: January 2024

BackgroundInflammation and obesity have been widely recognized to play a key role in Diabetes mellitus (DM), and there exists a complex interplay between them. We aimed to clarify the relationship between inflammation and DM, as well as the mediating role of obesity in the relationship.MethodsBased on the National Health and Nutrition Examination Survey (NHANES) 2005–2018. Univariate analyses of continuous and categorical variables were performed using t-test, linear regression, and χ2 test, respectively. Logistic regression was used to analyze the relationship between Systemic Immune-Inflammatory Index (SII) or natural logarithm (Ln)-SII and DM in three different models. Mediation analysis was used to determine whether four obesity indicators, including body mass index (BMI), waist circumference (WC), visceral adiposity index (VAI) and lipid accumulation product index (LAP), mediated the relationship between SII and DM.ResultsA total of 9,301 participants were included, and the levels of SII and obesity indicators (BMI, WC, LAP, and VAI) were higher in individuals with DM (p &lt; 0.001). In all three models, SII and Ln-SII demonstrated a positive correlation with the risk of DM and a significant dose–response relationship was found (p-trend &lt;0.05). Furthermore, BMI and WC were associated with SII and the risk of DM in all three models (p &lt; 0.001). Mediation analysis showed that BMI and WC mediated the relationship between SII with DM, as well as Ln-SII and DM, with respective mediation proportions of 9.34% and 12.14% for SII and 10.23% and 13.67% for Ln-SII (p &lt; 0.001).ConclusionOur findings suggest that increased SII levels were associated with a higher risk of DM, and BMI and WC played a critical mediating role in the relationship between SII and DM.
Simulating cardiac signals on 3D human models for photoplethysmography development
Authors: Wang Danyi , Chahl Javaan 
Published: January 2024

Introduction: Image-based heart rate estimation technology offers a contactless approach to healthcare monitoring that could improve the lives of millions of people. In order to comprehensively test or optimize image-based heart rate extraction methods, the dataset should contain a large number of factors such as body motion, lighting conditions, and physiological states. However, collecting high-quality datasets with complete parameters is a huge challenge.Methods: In this paper, we introduce a bionic human model based on a three-dimensional (3D) representation of the human body. By integrating synthetic cardiac signal and body involuntary motion into the 3D model, five well-known traditional and four deep learning iPPG (imaging photoplethysmography) extraction methods are used to test the rendered videos.Results: To compare with different situations in the real world, four common scenarios (stillness, expression/talking, light source changes, and physical activity) are created on each 3D human. The 3D human can be built with any appearance and different skin tones. A high degree of agreement is achieved between the signals extracted from videos with the synthetic human and videos with a real human-the performance advantages and disadvantages of the selected iPPG methods are consistent for both real and 3D humans.Discussion: This technology has the capability to generate synthetic humans within various scenarios, utilizing precisely controlled parameters and disturbances. Furthermore, it holds considerable potential for testing and optimizing image-based vital signs methods in challenging situations where real people with reliable ground truth measurements are difficult to obtain, such as in drone rescue.
Differential Modulation of Mouse Intestinal Organoids with Fecal Luminal Factors from Obese, Allergic, Asthmatic Children
Authors: Córdova Samir , Tena-Garitaonaindia Mireia , Álvarez-Mercado Ana Isabel , Gámez-Belmonte Reyes , Gómez-Llorente Mª Amelia , Sánchez de Medina Fermín , Martínez-Cañavate Ana , Martínez-Augustin Olga , Gómez-Llorente Carolina 
Published: January 2024

Asthma is a multifactorial condition that can be associated with obesity. The phenotypes of asthma in lean and obese patients are different, with proinflammatory signatures being further elevated in the latter. Both obesity and asthma are associated with alterations in intestinal barrier function and immunity, and with the composition of the intestinal microbiota and food consumption. In this study, we aimed to establish an organoid model to test the hypothesis that the intestinal content of lean and obese, allergic, asthmatic children differentially regulates epithelial intestinal gene expression. A model of mouse jejunum intestinal organoids was used. A group of healthy, normal-weight children was used as a control. The intestinal content of asthmatic obese children differentially induced the expression of inflammatory and mitochondrial response genes (Tnf-tumor necrosis factor, Cd14, Muc13-mucin 13, Tff2-Trefoil factor 2 and Tff3, Cldn1-claudin 1 and 5, Reg3g-regenerating family member 3 gamma, mt-Nd1-NADH dehydrogenase 1 and 6, and mt-Cyb-mitochondrial cytochrome b) via the RAGE-advanced glycosylation end product-specific receptor, NF-κB-nuclear factor kappa b and AKT kinase signal transduction pathways. Fecal homogenates from asthmatic normal-weight and obese children induce a differential phenotype in intestinal organoids, in which the presence of obesity plays a major role.
Jeunes de 16-18 ans sans diplôme ni qualification. Les propositions des politiques publiques entre 2008 et 2012
Authors: Larguèze Brigitte , Mathey-Pierre Catherine , Trancart Danièle , Gomel Bernard 
Published: January 2024

Un état des lieux des politiques publiques pour les jeunes de 16 à 18 ans, publié en septembre 2008, fait l’objet d’une nouvelle publication dans ce numéro en ligne. Il est accompagné de cette présente mise à jour qui recense les principales réformes et les nouveaux dispositifs mis en œuvre en formation initiale sur la période 2008-2012, ainsi que l’évolution des mesures proposées aux sortants non diplômés. Une actualisation des données statistiques issues de l’enquête Génération 2007 du Céreq, à partir d’une extraction spécifique des jeunes sortants entre 16 et 18 ans, permet de préciser leur profil et leur situation trois ans après leur sortie de formation initiale.
O jogo de tabuleiro como ferramenta educativa no ensino sobre Síndrome Metabólica para estudantes de ensino superior
Authors: Monici Ana Carolina Pinheiro , Guilherme Fernanda Ribeiro de Lima Alves , Da Silva Camila Lopes Moreira , Guinhoni Victória Fátima Sabino Bernardo , Da Silva Marquisson Afonso Oliveira , Silva Daniel Gontijo Sousa 
Published: January 2024

Mudanças no processo educacional em busca de tecnologias inovadoras são cada vez mais observadas na atualidade. As novas tecnologias educacionais incluem os jogos como meio de metodologia ativa de ensino e aprendizagem. Os jogos de tabuleiro são um exemplo disso, e pesquisas mostram sua eficácia no processo de retenção e obtenção do conhecimento. O tema abordado com essa nova tecnologia foi "as repercussões da Síndrome Metabólica na qualidade de vida de adolescentes e crianças", já que este tema é importante e possui alta incidência mundial, principalmente no contexto atual.
PRECONDITIONS FOR THE TELECOMMUNICATION RATING OF THE MEMBER STATES OF THE REGIONAL COMMONWEALTH IN THE FIELD OF COMMUNICATIONS
Authors: Резникова Н.П. , Артемьева Г.С. 
Published: January 2024

Разнообразие, сложность, неравномерность развития сферы электросвязи/ИКТ (ЭИКТ) государств-участников Регионального содружества в области связи (ГУ РСС) повышает актуальность и значимость осуществления мониторинга сбалансированности развития инфраструктуры ЭИКТ Региона. Рассмотрены предпосылки и целесообразность формирования рейтинга ГУ РСС в сфере ЭИКТ. Показано, что одним из возможных инструментов для отражения явлений гармонизации развития ЭИКТ в РСС и формирования рейтинга может служить соответствующий общий для РСС индекс, структура которого представлена в статье.
The diversity, complexity, and uneven development of the telecommunications/ICT sector (telecom/ICT) of the member states of the Regional Commonwealth in the Field of Communications (MS RCC) increases the relevance and significance of monitoring the balance of the Region’s telecom/ICT infrastructure development. The preconditions and feasibility for the formation of the MS RCC rating in the field of telecom/ICT are considered. It is shown that one of thepossible tools for reflecting the phenomena of harmonization of telecom/ICT development in the RCC and the formation of a rating can be the corresponding general index for the RCC, the structure of which is presented in the article.
STATISTICAL ASSESSMENT OF ANTENNA RADIATION PATTERN ENVELOPES FOR ELECTROMAGNETIC COMPATIBILITY STUDIES
Authors: Ястребцова О.И. 
Published: January 2024

В статье представлен анализ используемых в исследованиях электромагнитной совместимости эталонных диаграмм направленности антенн в виде пиковой и средней огибающих боковых лепестков. Рассмотрение проведено в приближении, что уровень излучения в направлении, отличном от направления главного лепестка, является случайной величиной. Проведенный в статье анализ показал, что используемая для получения средней огибающей из пиковой огибающей величина порядка 3–4 дБ дает уровень излучения, превышаемый приблизительно в течение 50–60% времени. Таким образом, использование средних огибающих приводит к переоценке уровней излучения антенн в случае исследований, проводимых методом Монте-Карло, однако их использование вполне оправданно в случае расчета суммарной помехи в исследованиях, не учитывающих проценты времени, так как позволяет корректно учесть мощность излучения антенны. В свою очередь, использование пиковой огибающей целесообразно в исследованиях, в которых защитный критерий не должен превышаться в 100% времени.
This article presents the analysis of the reference antenna radiation patterns used in electromagnetic compatibility studies in the form of peak and average sidelobe envelopes. The consideration was carried out assuming that the radiation level in directions other than the main beam is a random value. The analysis carried out in the article has shown that a value of about 3–4 dB used to obtain the average envelope from the peak envelope gives a radiation level that may be exceeded approximately 50–60% of the time. So the use of average envelopes leads to an overestimation of radiation levels in the case of studies conducted by the Monte Carlo method, but its use is justified in the case of calculating the aggregate interference that does not take into account percentages of time since it allows to correctly take into account the radiation power of the antenna. The use of the peak envelope is appropriate in studies where the protection criterion cannot be exceeded 100% of the time.