bluuebunny/crossref_metadata_2025_split huggingface dataset:
Expert Consensus on Molecular Tumor Boards in Taiwan: Joint Position Paper by the Taiwan Oncology Society and the Taiwan Society of Pathology
Authors: Chen Ming-Huang , Li Wan-Shan , Liao Bin-Chi , Wu Chiao-En , Li Chien-Feng , Hsieh Chia-Hsun , Kuan Feng-Che , Tzeng Huey-En , Hang Jen-Fan , Chiang Nai-Jung , Chen Tse-Ching , Chen Tom Wei-Wu , Chang John Wen-Cheng , Hsieh Yao-Yu , Chen Yen-Lin , Yeh Yi-Chen , Liang Yi-Hsin , Su Yu-Li , Lai Chiung-Ru , Yang James Chih-Hsin 
Published: January 2024

Abstract

Background:
The Taiwan Oncology Society (TOS) and the Taiwan Society of Pathology (TSP) have collaborated to present a joint position paper on the molecular tumor boards (MTBs) within the medical institutions of Taiwan.

Materials and Methods:
To raise awareness of MTBs among health-care professionals, policymakers, and the public, a total of 20 experts from TOS and TSP formulated a joint consensus statement through a voting process.

Results:
The joint statement proposes key recommendations: (1) MTB discussions encompass diverse molecular analyses including next-generation sequencing (NGS), RNA sequencing, whole-exon sequencing, and whole-genomic sequencing addressing relevant genomic changes, tumor mutation burden, microsatellite instability, and specific biomarkers for certain cancers. (2) MTB meetings should involve multidisciplinary participants who receive regular updates on NGS-related clinical trials. (3) Prioritize discussing cases with unique clinical needs, gene alterations lacking treatments, untreatable neoplasms, or oncogenes unresponsive to targeted therapies. (4) Base MTB discussions on comprehensive patient data, including genetics, pathology, timing of specimen collection, and NGS outcomes. (5) MTBs offer treatment recommendations: standard therapies, off-label use, clinical trials, genetic counseling, and multidisciplinary reviews. (6) MTB effectiveness can be gauged by member composition, case reviews, treatment suggestions, and patient outcomes. Encourage government incentives for MTB engagement.

Conclusion:
The primary aim of this initiative is to promote the advancement of precision oncology in Taiwan.
Dose-dense neoadjuvant chemotherapy in triple-negative breast cancer: Real-world data from a developing country
Authors: Sharma Rakesh Kumar , Gogia Ajay , Deo SVS , Sharma Dayanand , Mathur Sandeep , Sagiraju Hari Krishna Raju 
Published: January 2024

Background:
Dose-dense adjuvant chemotherapy has been shown to be associated with improved long-term survival outcomes in triple-negative breast cancer (TNBC). However, there is a lacuna of data on the benefits of dose-dense neoadjuvant chemotherapy (NACT) in TNBC.

Methods:
This retrospective study included 217 newly diagnosed cases of TNBC treated with a sequential anthracycline and taxane-based NACT, followed by definitive surgery. Study groups consisted of 137 patients who received 3-weekly conventional chemotherapy (cNACT group) and 80 patients with 2-weekly dose-dense NACT (ddNACT group). Pathological complete response (pCR) rates, relapse-free survival (RFS), overall survival (OS), and grade-3/4 chemotoxicities were compared across the groups.

Results:
No significant difference in the pCR rate (32.8% versus 31.3%; P = 0.808) was observed across the study groups. Relapse rate was lower in the ddNACT group compared to the cNACT group (odds ratio [OR]: 0.51, 95% confidence interval [CI]: 0.27–0.95). However, ddNACT had no RFS advantage over conventional chemotherapy (median RFS: not reached versus 56.1 months in cNACT; hazard ratio: 0.90, 95% CI: 0.52–1.53). OS was also comparable in both the groups with a 3-year survival rate of 78.8% (95% CI: 60.9–89.2) in the ddNACT group versus 84.3% (95% CI: 74.8–90.4) in the cNACT group. Younger age, menopause, the Eastern Cooperative Oncology Group ECOG status, and pCR were significantly associated with OS in our cohort. Grade-3 toxicities were comparable in both groups.

Conclusions:
This observational study focusing on ddNACT among TNBC patients demonstrated significant differences in the relapse rate with no survival benefits. Differential effects of ddNACT by tumor presentation (early vs. late), tumor size, tumor biology, and cost–benefits of granulocyte colony-stimulating factor support with such regimens need further exploration.
Bortezomib-based induction therapy followed by autologous hematopoietic cell transplantation in newly diagnosed multiple myeloma patients: A single-center experience and review of Indian literature
Authors: Kathrotiya Manthan , Radhakrishnan Vivek , Bhave Saurabh J. , Nag Arijit , Arora Neeraj , Roychoudhry Mita , Parihar Mayur , Mishra Deepak , Nair Reena , Chandy Mammen , Kumar Jeevan 
Published: January 2024

Introduction:
High-dose chemotherapy with melphalan, followed by autologous hematopoietic stem cell transplantation (AHCT) remains the standard of care for consolidation therapy of fit patients with newly diagnosed multiple myeloma (NDMM), for more than 20 years now.

Material and Methods:
This is a retrospective study of NDMM patients who underwent AHCT at our center from 2011 to 2018. Data was undertaken using the hospital electronic medical records (EMR).

Results:
Among transplant eligible patients (which were 764), 78 patients (10.2%) underwent AHCT. The predominant stage in the study cohort was International Scoring System (ISS)-III (55%), and IgG-kappa (44%) was the commonest subtype of multiple myeloma (MM). Light chain myeloma was found in 23.5% of patients. Pretransplant, 42%, 48%, and 10% patients were in more than very good partial response (>VGPR), very good partial response (VGPR), and partial response (PR), respectively. The median duration of follow-up was 57.2 months (range: 12.1–120.2 months). The entire cohort’s 5-year overall survival (OS) and progression-free survival (PFS) were 89.1% and 41.8%, respectively.

Conclusion:
Bortezomib based triplet induction regimens were effective and well tolerated in this retrospective analysis of Indian patients. We observed that AHCT effectively achieves deep and durable remission in MM.
Spatial Patterns of Heaping in Age Data among Literates, Illiterates, and Numeracy–Literacy Correlates: A Cross-Sectional Analysis of Census 2011, of India
Authors: Datta Jayanta , Sinha Prasenjit 
Published: January 2024

Background:
Accurate information on age is an essential prerequisite for demographic and epidemiological studies. This study analyzed the age data quality among the literate and illiterate (combined, rural, urban) population and examined the association between data quality and literacy.

Material and Method:
Secondary data on age statistics and literacy were obtained from census 2011. We measured age data quality for literates and illiterates (combined, rural, urban) by transforming Whipple’s index known as ABCC, abbreviated based on surnames of the developers A’Hearn, Baten, and Crayen (2009). Correlation tests between literacy and ABCC were performed. RStudio (Version 1.3.1073) was used.

Result:
Computed ABCC indices in majority states (union territories) for literates (data quality rough) were higher than illiterates (data quality very rough). Urban data among literates and rural data among illiterates were comparatively superior. Correlation between ABCC and literacy rates for (i) literate combined (R = 0.84, P = 3.5e-10), (ii) literate rural (R = 0.8, P = 1.1e-08), (iii) literate urban (R = 0.8, P = 1e-08), (iv) illiterate combined (R = 0.54, P = 9e-04), (v) illiterate rural (R = 0.48, P = 0.0034), and (vi) illiterate urban (R = 0.73, P = 6.4e-07) was significant. Age data quality for both literates and illiterates was poor. There was heaping at terminal digits “0” and “5” even among literates, which contradicts the theoretical expectation of quality data among literates.

Conclusion:
Correlations between data quality and literacy were significant, with comparatively lower magnitude among illiterates, which indicates the role of literacy in yielding quality data. Awareness, training, ADHAAR-based enumeration, and digitization may be suggested for better age data.
“I Would Rather Die Drinking than take the Medicine”: Role of Alcohol Use Disorder in Loss-to-follow-up of Tuberculosis Treatment in a Rural Area of Ballabgarh, Haryana
Authors: Khaitan Anwita , Rai Sanjay K. , Krishnan Anand , Gupta Sanjeev K. , Kant Shashi , Khilnani Gopi C. 
Published: January 2024

Introduction:
Alcohol use disorder (AUD) is a significant risk factor for tuberculosis (TB) treatment loss-to-follow-up (LTFU). This field-based study was undertaken to understand the role of AUD and TB treatment LTFU and the reasons behind this association in a rural area of Ballabgarh, Haryana.

Material and Methods:
TB patients who had completed their treatment and who had been LTFU were included in the study, along with the National TB Elimination Program (NTEP) staff, healthcare providers, family, and community members from Ballabgarh block of the north Indian state of Haryana. In-depth interviews (IDIs) and focused group discussions (FGDs) were conducted to gauge the perceptions of stakeholders regarding reasons for LTFU, especially in the context of alcohol use. Inductive analysis of the transcripts was done in keeping with the grounded theory, and themes with their sub-themes were identified. A conceptual framework of TB-AUD was constructed, and potential areas for intervention were determined.

Results:
Fifty-eight IDIs and four FGDs were conducted in mid-2018. Almost all key informants and many patient participants believed that alcohol use makes TB patients highly susceptible to treatment LTFU. Key themes identified were shared personality traits and attitudes, combined side effects of anti-tubercular drugs and alcohol use, lack of family support, and an adverse financial situation.

Conclusion:
These findings call for a change in NTEP’s approach to AUD-TB. Interventions may include collecting alcohol use information at patient enrolment and closure, integrating brief interventions for alcohol cessation in NTEP, and linking patients to deaddiction centers with the provision of appropriate dietary and financial support.
Development and Validation of a Questionnaire to Measure a Medical Student’s Interest in the Subject of Community Medicine
Authors: Ali Syed I. , Begum Jarina , Kumar Abhishek , Shikha Swati , Patil Sachin K. , Sinha Ratnesh 
Published: January 2024

Background:
Lack of interest has been cited by many studies as the predominant cause for students undervaluing the subject of Community Medicine. However, there are few valid and reliable tools that could measure this interest. To develop and validate a questionnaire to measure a medical student’s interest in the subject of Community Medicine.

Material and Methods:
Cross-sectional study conducted at MTMC Jamshedpur. The Community Medicine Interest Questionnaire (CMIQ) was developed in two phases: item generation and item reduction. Items were generated through a review of the literature, focused group discussions, and in-depth interviews. In the item reduction phase, the content and construct validity of the questionnaire were ascertained. Content validity was carried out by a group of experts based on three parameters: the interrater agreement on the representativeness of the item, the interrater agreement on the clarity of the items, and the content validity index. The construct validity was ascertained through pilot testing of 480 responses from undergraduate medical students. Exploratory factor analysis through principal axis factoring and Promax rotation.

Results:
Twenty-five items were generated. Three of these items were removed following expert validation. Furthermore, three items were removed after pilot testing. The resulting CMIQ consisted of 19 items distributed over three dimensions: feeling, value, and predisposition to reengage toward the subject. The internal consistency of each of the subscales was ascertained.

Conclusions:
CMIQ is a valid and reliable tool that can be used to measure such interest for providing educational interventions.
Factors Influencing Social and Community Participation of People with Spinal Cord Injury in Karnataka, India
Authors: Babu Heavenna , Sriraman Sheetal , Karthikbabu Suruliraj , Sophia P. , Kumar Senthil N. S. 
Published: January 2024

Background:
Social and community participation are major indicators to assess the adequacy of treatment and rehabilitation in patients with spinal cord injury (SCI). This study examined the relationship between functional independence, level of disability, and social and community participation among people with SCI in India.

Materials and Method:
In this cross sectional study, 110 persons with SCI, aged 18 years and above participated in a community setting, in Karnataka, India. Spinal Cord Independence Measure Version III-self-reporting (SCIM III-SR), Craig Handicap Assessment and Reporting Technique (CHART), and WHO Disability Assessment Schedule 2.0 (WHODAS) were the clinical outcome measures. Spearman’s correlation and stepwise multiple linear regression were done to determine association and identify the factors determining the community participation of people with SCI.

Results:
CHART physical independence had a positive correlation with SCIM self-care (R = 0.446) and SCIM mobility (r = 0.434). CHART cognitive independence (R = -0.38) and CHART mobility (R = -0.396) had a weak correlation with WHODAS. SCIM self-care and SCIM mobility (R2 = 0.34) were determinants of CHART cognitive independence. SCIM respiratory and sphincter management and SCIM self-care (R2 = 0.327) were determinants of CHART mobility.

Conclusion:
Self-care and mobility of people with SCI determine their ability to successfully reintegrate into the community, warranting a comprehensive community rehabilitation program.
Assessing the Burden of COVID-19 among Children Aged 6-14 Years in Karnataka, India: A Cross-sectional Survey
Authors: Rajagopal Padma M , Sil Satyam , Dinesh Prameela , Shiju Shilpa , Arunkumar D P , Ramaiah Srinivas S , Lalitha Hande R , Mamatha T , Kantinath P Ainapure , Pujari Lokesh , Pradeep BS , Shenoy Anusha B , Desai Anita , Munivenkatappa Ashok , Gudi Chetan S , Babu Giridhara R , Sudarshan M K 
Published: January 2024

Background:
India experienced three coronavirus disease (COVID-19) waves, with the third attributed to the highly contagious Omicron variant. Before the national vaccination rollout for children above 6, understanding severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) immunoglobulin G (IgG) positivity in the pediatric population was essential. This study aims to assess the burden of Covid-19 infection and to estimate the seroprevalence in children aged 6 to 14 years in the state of Karnataka.

Material and Methods:
We surveyed 5,358 children aged 6-14 across Karnataka using 232 health facilities, from June 6 to 14, 2022. We determined the sample size using the PPS (Population Proportional to Size) technique and employed cluster sampling. We tested all participants for SARS-CoV-2 IgG with an enzyme-linked immunosorbent assay (ELISA) kit and SARS-CoV-2 RNA with reverse transcription-polymerase chain reaction (RT-PCR). We sequenced samples with a cycle threshold (CT) value below 25 using whole genomic sequencing (WGS).

Result:
We found an adjusted seroprevalence of IgG at 75.38% statewide, and we found 0.04% of children RT-PCR positive for COVID-19. We determined a case-to-infection ratio of 1:37 and identified the SARS-CoV-2 strains as Omicron, BA.5, and BA.2.10.

Conclusion:
The study showed a high seroprevalence of IgG among children with low active infection. Omicron, BA. 5, and BA. 2.10 variants were detected through WGS.
Prevalence and Severity of Periodontal Disease and its Association with Type-II Diabetes Mellitus and Smoking by Using Periodontal Screening and Recording: A Retrospective Study
Authors: Devi Oinam Monica , Sood Shaveta , Gupta Jyoti , Jain Ashish 
Published: January 2024

Background:
Periodontal screening recording (PSR) is considered a quick, reliable, reproducible valuable screening tool for periodontal disease. This study aims to find the prevalence and severity of periodontal disease and its association with self-reported diabetic status and smoking history of the patients by using PSR codes over a period of 2 years.

Material and Methods:
This was a cross-sectional retrospective study in a dental hospital in Chandigarh. Data of 10,882 patients comprising self-reported history of smoking (893) and diabetes (725) patients were assessed for the prevalence of periodontal disease by using PSR codes. Pearson Chi-Square test was used for statistical evaluation of PSR codes data.

Results:
Out of a total of 65,292 sextants assessed, the maximum and minimum reported PSR codes were 2 and 4, respectively. Gingivitis was found to be the most prevalent, followed by periodontitis and periodontal health in the total assessed population (P < 0.001). Mucogingival problems and complete edentulism were found to be more prevalent in posterior sextants in comparison to anterior sextants. Both self-reported smokers and type-II diabetes mellitus patients presented gingivitis as the most common clinical presentation, with the highest prevalence seen in the 55–74-year age group, which also comprised the group with maximum mucogingival problems and edentulism.

Conclusion:
This study gives an overview of patients’ general oral health status and reflects the burden of periodontal disease in the Chandigarh region, thus contributing to the national oral health data.
Musculoskeletal Comorbidities among known Diabetes Patients, their Quality of Life, and Healthcare Costs: A Comparative Study From a Tertiary Care Hospital in Uttarakhand
Authors: Lekhwani Seema , Nath Bhola , Gupta Shiv Dutt , Kumari Ranjeeta , Vaswani Narain Das , Pawar Neeraj 
Published: January 2024

Introduction:
Diabetes is a chronic disorder with long-term sequelae and multisystem manifestation. Burden of diabetes in on the rise. Presence of other morbidities can not only have a detrimental effect on the disease treatment and recovery course, but also on the financial burden and quality of life. Present study aims to investigate how musculoskeletal conditions affect individuals with diabetes compared to those without the condition.

Material and Methods:
A comparative study was conducted among patients attending the outpatient department of a tertiary care hospital in North India to assess the burden of musculoskeletal disorders in people with and without diabetes. A total of 195 diabetes patients and an equal number of individuals without diabetes were sequentially enrolled from the outpatient department (OPD).

Results:
Burden of musculoskeletal comorbidities was significantly higher (46.2%) among people with diabetes than the comparison group (25.1%). The overall odds ratio (OR) for comorbidities of musculoskeletal system was 2.5 times higher in diabetes cases as compared to individuals without diabetes. The OR for rheumatoid arthritis, chronic backache, and osteoarthritis was found to be 3.6, 2.9, and 1.7 respectively. Poor quality of life and higher direct cost of treatment were found among diabetes cases with musculoskeletal comorbidities as against those without these comorbidities.

Conclusion:
Presence of musculoskeletal comorbidity is high among diabetes patients, and it has an impact on the quality of life and treatment cost. Screening for musculoskeletal comorbidities should be included as part of the diabetes complication assessment to allow for early detection and treatment.
Family Adoption Program for Undergraduate Medical Students at a New Medical School of Jharkhand: An Experience and SWOC Analysis
Authors: Shikha Swati , Kumar Abhishek , Begum Jarina , Ali Syed Irfan , Tripathy Sunita 
Published: January 2024

Introduction:
Family adoption program (FAP) incorporated into the undergraduate medical education curriculum is beneficial to all stakeholders involved. Many medical colleges have started FAP at different times and various levels based on resources availability, feasibility, and accessibility. This article is intended to cover the process of FAP implementation, the strength, weakness, opportunities, and challenges at various levels, and its scope in future.

Methodology:
FAP was launched by adopting a hamlet 17 km away from the college. During the foundation course, orientation lessons and logbook discussions were conducted online before the actual field visit. During the initial visit, families were assigned, which was followed by collecting sociodemographic information, a plantation drive, and organizing medical camp/ door to door screening in the last visits for phase one students.

Observations:
The strengths perceived were early community exposure of students and leadership skills, and the weaknesses were allocating adequate number of slots in the curriculum, adopting families far away, etc., Similarly, FAP has an opportunity to achieve the larger goal of Heath for All in terms of identifying, following up, and managing various socio clinical cases in the adopted families. However, few challenges can pose as it progresses across other phases, such as language problem, allotment of problem families, existing social pathology in family, cultural taboos, etc.,

Conclusion:
The article suggests that once a student leaves, another student should continue the cycle of adoption and provide continuum care of services to prevent the family from being orphaned.
Percutaneous Placement and Management of High-flow Catheter for Hemodialysis: The Case for DualCath, Two-tunneled, Single-lumen Silicone Catheters
Authors: Canaud Bernard , Leray-Moragues Hélène , Klouche Kada , Morena Marion , Chenine Leila , Miller George , Cristol Jean-Paul , Canaud Ludovic 
Published: January 2024

Abstract

Introduction:
Tunneled central venous catheters (CVCs) are often regarded as the final choice for vascular access in patients needing extracorporeal renal replacement therapy due to their higher morbidity, lower performance, and increased cost. The inherent limitations of tunneled CVCs have been recognized and extensively analyzed in numerous studies.

Materials and Methods:
The objective is to offer a comprehensive technical note on the percutaneous placement and management of high-flow DualCath (DC) for hemodialysis, involving the simultaneous insertion of two tunneled single-lumen silicone catheters through a single skin incision and vein puncture. In addition, we aim to summarize the results derived from our extensive clinical experience.

Results:
This 20-year study involved the placement of 1035 DC devices. The main indications were end-stage kidney disease in 859 cases, acute kidney injury in 50 cases, and miscellaneous purposes in 30 cases. Most of the insertions were in the internal jugular vein, with varying dwell times averaging 213 ± 335 days. In total, the DC devices were used for 594 patient-years.

Conclusion:
DC can be placed using a minimally invasive percutaneous method in both chronic and acute settings, showcasing its exceptional versatility. The design and geometry of the two silicone cannulas are precisely tailored to meet the needs of clinicians, focusing on achieving optimal flow performance, and ensuring adequate dialysis.