bluuebunny/crossref_metadata_2025_split huggingface dataset:
SOLID: a novel similarity metric for mono-modal and multi-modal deformable image registration
Authors: Tzitzimpasis Paris , Zachiu Cornel , Raaymakers Bas W , Ries Mario 
Published: December 2023

Abstract
Medical image registration is an integral part of various clinical applications including image guidance, motion tracking, therapy assessment and diagnosis. We present a robust approach for mono-modal and multi-modal medical image registration. To this end, we propose the novel shape operator based local image distance (SOLID) which estimates the similarity of images by comparing their second-order curvature information. Our similarity metric is rigorously tailored to be suitable for comparing images from different medical imaging modalities or image contrasts. A critical element of our method is the extraction of local features using higher-order shape information, enabling the accurate identification and registration of smaller structures. In order to assess the efficacy of the proposed similarity metric, we have implemented a variational image registration algorithm that relies on the principle of matching the curvature information of the given images. The performance of the proposed algorithm has been evaluated against various alternative state-of-the-art variational registration algorithms. Our experiments involve mono-modal as well as multi-modal and cross-contrast co-registration tasks in a broad variety of anatomical regions. Compared to the evaluated alternative registration methods, the results indicate a very favorable accuracy, precision and robustness of the proposed SOLID method in various highly challenging registration tasks.
Super-resolution dual-layer CBCT imaging with model-guided deep learning
Authors: Zhu Jiongtao , Su Ting , Zhang Xin , Cui Han , Tan Yuhang , Zheng Hairong , Liang Dong , Guo Jinchuan , Ge Yongshuai 
Published: December 2023

Abstract

Objective. This study aims at investigating a novel super resolution CBCT imaging approach with a dual-layer flat panel detector (DL-FPD). Approach. With DL-FPD, the low-energy and high-energy projections acquired from the top and bottom detector layers contain over-sampled spatial information, from which super-resolution CT images can be reconstructed. A simple mathematical model is proposed to explain the signal formation procedure in DL-FPD, and a dedicated recurrent neural network, named suRi-Net, is developed based upon the above imaging model to nonlinearly retrieve the high-resolution dual-energy information. Physical benchtop experiments are conducted to validate the performance of this newly developed super-resolution CBCT imaging method. Main Results. The results demonstrate that the proposed suRi-Net can accurately retrieve high spatial resolution information from the low-energy and high-energy projections of low spatial resolution. Quantitatively, the spatial resolution of the reconstructed CBCT images from the top and bottom detector layers is increased by about 45% and 54%, respectively. Significance. In the future, suRi-Net will provide a new approach to perform high spatial resolution dual-energy imaging in DL-FPD-based CBCT systems.
X-ray absorption near-edge, terahertz and Raman spectroscopies evidence growth-orientation dependent cation order, phase transitions and spin–phonon coupling in half-metallic Ca2FeMoO6 thin films
Authors: Yadav Ekta , Prajapati G L , Rajput Parasmani , Mavani Krushna R 
Published: December 2023

Abstract
The disorder due to anti-site cation distribution is intrinsic to the double perovskites wherein the crystal orientations of the substrate template are predicted to offer different degrees of cation order in thin film form. To demonstrate this effect, epitaxial thin films of half-metallic double perovskite Ca2FeMoO6 (CFMO) were prepared on (100) and (111) oriented LaAlO3 substrates in vacuum and nitrogen atmospheres. The findings using X-ray absorption near-edge structure, Terahertz (THz) and Raman spectroscopies, in combination with magnetization show that (111) epitaxial template effectively restricts the Fe–Mo anti-site cation disorder. A resultantly enhanced cation order in (111) films induces dramatic transformations in its properties as follows: (i) significantly enhanced ferromagnetic exchange interactions and saturation magnetization, (ii) a significant increase in the Curie temperatures, (iii) a metallic behavior down to much lower temperature (∼75 K) compared to that down to 200 K for (100) film, (iv) an enhanced spin–phonon coupling. The complex THz optical conductivity spectra evaluated in the framework of Drude and Drude–Smith phenomenological models and the temperature-dependent Raman data fitted to the Balkanski model corroborate well to indicate an enhanced cation order in (111) films. While this study establishes a dominant role of crystallographic orientation in the much-desired control of cation order in double perovskites, a demonstration of the same in room temperature half-metallic CFMO system could reinforce its technological utility both as active and passive components in emergent spintronic functionalities.
Influence of adding manganese chromium-layered double oxide on the optical, magnetic and dielectric properties of cobalt spinel ferrite nanoparticles
Authors: Rekaby M , Abou-Aly A I 
Published: December 2023

Abstract
Hydrotalcite-like materials such as layered double oxides (LDOs) are promising materials for many technological applications. Linking the multilayer structure of LDOs with the exceptional optical, magnetic, and dielectric properties of spinel ferrites could result in advanced nanocomposites for photovoltaic, magneto-recording, and high-frequency applications. For that purpose, nanocomposites of type manganese chromium-layered double oxide/cobalt spinel ferrite, (MnCr)-LDOx/CoFe2O4 (x = 1, 3, and 5 wt%), were produced by the co-precipitation route. X-ray diffraction (XRD) analysis showed the successful incorporation of MnCr-LDO in CoFe2O4 lattice. After a 5 wt% addition of MnCr-LDO, the lattice parameter of pure CoFe2O4 increased from 8.3832 Å to 8.4136 Å, the crystallite size increased from 18.7 nm to 21.7 nm, and the strain dropped from 2.15 to 2.04. Transmission electron microscopy (TEM) revealed cubic morphologies for (MnCr)-LDOx/CoFe2O4 nanocomposites. Two strong absorbance peaks appeared in the Ultraviolet- visible (UV-vis) spectra (at ∼270 and ∼370 cm−1). The energy band gap and Urbach energy were estimated for the prepared samples. The composite sample (MnCr)-LDO1 wt%/CoFe2O4 recorded the highest band gap values (Eg1 = 3.39 eV, Eg2 = 4.46 eV, and Eg3 = 5.89 eV), while the (MnCr)-LDO3 wt%/CoFe2O4 sample had a relatively high Urbach energy value (1.35 eV). Vibrating sample magnetometer (VSM) analysis showed room temperature ferromagnetic (RTFM) behavior for the prepared composites. The saturation magnetization (Ms) value declined as the MnCr-LDO addition to CoFe2O4 increased, and the (MnCr)-LDO3 wt%/CoFe2O4 sample acquired the highest Ms (64.428 emu g−1) among all the produced composites. Pure CoFe2O4 had a much higher coercivity (Hc = 1158.1 Oe) than (MnCr)-LDOx/CoFe2O4 (x = 1, 3, and 5 wt%) nanocomposites (Hc = 1119.8, 978.48, and 984.16 Oe). Moreover, complex impedance spectroscopy measurements were performed in frequency range of 50 Hz- 5 MHz using Nyquist plots and electric modulus analysis. Nyquist plots were fitted to an analogous electric circuit consisting of a resistor R1 connected in series to two parallel constant phase element- resistor circuits (CPE-R). On the other hand, a different circuit comprises of two CPE, capacitor (C1), and resistor all connected in parallel was used to model CoFe2O4.
Structural changes in the crystal lattice in enamel under Er,Cr:YSGG laser irradiation and oven heated by Rietveld analysis
Authors: Rabelo Neto J S , da Ana P A , Mazzocchi V L , Valério M E G , Zezell D M 
Published: December 2023

Abstract
Changes in the crystal lattices and compositions of the dental enamel powders were evaluated after oven or Er,Cr:YSGG laser irradiation. A decrease in the Ca/P ratio to levels close to the ideal theoretical value of laser irradiation caused a considerable decrease in the hydroxyapatite crystallite size but without changes in the crystallographic phase. These changes alter the material, can affect the demineralization process, and are useful for the prevention of caries and dental erosion.
Photonuclear reactions on stable isotopes of selenium at bremsstrahlung end-point energies of 10−23 MeV
Authors: Rasulova F.A. , Aksenov N.V. , Alekseev S.I. , Aliev R.A. , Belyshev S.S. , Chuprakov I. , Fursova N.Yu. , Madumarov A.S. , Khushvaktov J.H. , Kuznetsov A.A. , Yuldashev B.S. 
Published: December 2023

Abstract
In this study, experiments were performed at bremsstrahlung end-point energies of 10−23 MeV with the beam from the MT-25 microtron using the
γ-activation technique. The experimental values of relative yields were compared with theoretical results obtained on the basis of TALYS with the standard parameters and the combined model of photonucleon reactions. Including isospin splitting in the combined model of photonucleon reactions allows describing experimental data on reactions with proton escape in the energy range from 10 to 23 MeV. Therefore, taking into account isospin splitting is necessary for a correct description of the decay of the giant dipole resonance.
Strahler number of natural language sentences in comparison with random trees
Authors: Tanaka-Ishii Kumiko , Tanaka Akira 
Published: December 2023

Abstract
The Strahler number was originally proposed to characterize the complexity of river bifurcation and has found various applications. This article proposes a computation of the Strahler number’s upper and lower limits for natural language sentence tree structures. Through empirical measurements across grammatically annotated data, the Strahler number of natural language sentences is shown to be almost 3 or 4, similar to the case of river bifurcation as reported by Strahler (1957 Eos Trans. Am. Geophys. Union
38 913–20). Based on the theory behind this number, we show that there is a kind of lower limit on the amount of memory required to process sentences. We consider the Strahler number to provide reasoning that explains reports showing that the number of required memory areas to process sentences is 3–4 for parsing (Schuler et al 2010 Comput. Linguist.
36 1–30), and reports indicating a psychological ‘magical number’ of 3–5 (Cowan 2001 Behav. Brain Sci.
24 87–114). An analytical and empirical analysis shows that the Strahler number is not constant but grows logarithmically. Therefore, the Strahler number of sentences is derived from the range of sentence lengths. Furthermore, the Strahler number is not different for random trees, which could suggest that its origin is not specific to natural language.
Decellularized extracellular matrix scaffold seeded with adipose-derived stem cells promotes neurorestoration and functional recovery after spinal cord injury through Wnt/β-catenin signaling pathway regulation
Authors: Su Xiaochen , Teng Menghao , Zhang Yingang , Ji Wenchen 
Published: December 2023

Abstract
Spinal cord injury (SCI) causes tissue destruction and neuronal apoptosis, which impede neural function recovery. Therefore, promoting neuronal regeneration and neural pathway reconstruction is crucial. In this study, a novel and facile decellularized extracellular matrix (dECM) scaffold seeded with adipose-derived stem cells (ADSCs) (dECM scaffolds/ADSCs) was reported. The dECM scaffold maintained the original three-dimensional network structure of spinal cord tissue and contained various small pores. In vitro studies demonstrated that dECM scaffolds exhibited excellent biocompatibility, facilitated efficient adhesion and proliferation of ADSCs, and promoted the secretion of neurotrophin-3 and neuronal differentiation in the microenvironment after SCI. In vivo studies further showed that dECM scaffolds/ADSCs could alleviate inflammatory and apoptotic reactions, providing a favorable microenvironment for promoting endogenous nerve regeneration rather than glial scars formation, ultimately achieving recovery of hind limb function in rats. Notably, ICG-001 effectively reversed the therapeutic effect of dECM scaffolds/ADSCs, proving that dECM scaffolds/ADSCs promoted functional recovery after SCI by regulating the Wnt/β-catenin signaling pathway. Overall, dECM scaffolds/ADSCs can simulate the physiological characteristics of the spinal cord and exert neurorestorative potential, providing a new therapeutic strategy for SCI.
High-strength and high-toughness ECM films with the potential for peripheral nerve repair
Authors: Wang Fangfang , Wang Haiyang , Shan Xiaotong , Mei Jin , Wei Peng , Song Qinghua , Chen Weiwei 
Published: December 2023

Abstract
Extracellular matrix (ECM) scaffolds are widely applied in the field of regeneration as the result of their irreplaceable biological advantages, and the preparation of ECM scaffolds into ECM hydrogels expands the applications to some extent. However, weak mechanical properties of current ECM materials limit the complete exploitation of ECM’s biological advantages. To enable ECM materials to be utilized in applications requiring high strength, herein, we created a kind of new ECM material, ECM film, and evaluated its mechanical properties. ECM films exhibited outstanding toughness with no cracks after arbitrarily folding and crumpling, and dramatically high strength levels of 86 ± 17.25 MPa, the maximum of which was 115 MPa. Such spectacular high-strength and high-toughness films, containing only pure ECM without any crosslinking agents and other materials, far exceed current pure natural polymer gel films and even many composite gel films and synthetic polymer gel films. In addition, both PC12 cells and Schwann cells cultured on the surface of ECM films, especially Schwann cells, showed good proliferation, and the neurite outgrowth of the PC12 cells was promoted, indicating the application potential of ECM film in peripheral nerve repair.
A novel multi-layer modular approach for real-time fuzzy-identification of gravitational-wave signals
Authors: Barone Francesco Pio , Dell’Aquila Daniele , Russo Marco 
Published: December 2023

Abstract
Advanced LIGO and Advanced Virgo ground-based interferometers are instruments capable to detect gravitational wave (GW) signals exploiting advanced laser interferometry techniques. The underlying data analysis task consists in identifying specific patterns in noisy timeseries, but it is made extremely complex by the incredibly small amplitude of the target signals. In this scenario, the development of effective GW detection algorithms is crucial. We propose a novel layered framework for real-time detection of GWs inspired by speech processing techniques and, in the present implementation, based on a state-of-the-art machine learning approach involving a hybridization of genetic programming and neural networks. The key aspects of the newly proposed framework are: the well structured, layered approach, and the low computational complexity. The paper describes the basic concepts of the framework and the derivation of the first three layers. Even if, in the present implementation, the layers are based on models derived using a machine learning approach, the proposed layered structure has a universal nature. Compared to more complex approaches, such as convolutional neural networks, which comprise a parameter set of several tens of MB and were tested exclusively for fixed length data samples, our framework has lower accuracy (e.g. it identifies

45
%

of low signal-to-noise-ration GW signals, against

65
%

of the state-of-the-art, at a false alarm probability of 10−2), but has a much lower computational complexity (it exploits only 4 numerical features in the present implementation) and a higher degree of modularity. Furthermore, the exploitation of short-term features makes the results of the new framework virtually independent against time-position of GW signals, simplifying its future exploitation in real-time multi-layer pipelines for gravitational-wave detection with new generation interferometers.
Reply to ‘A commentary on “US power sector carbon capture and storage under the Inflation Reduction Act could be costly with limited or negative abatement potential”’
Authors: Grubert Emily , Sawyer Frances 
Published: December 2023

Abstract
Here we reply to a comment by Dr. Robert Kennedy from the US Department of Energy (DOE) on our paper ‘US power sector carbon capture and storage under the Inflation Reduction Act could be costly with limited or negative abatement potential,’ which found that the 45Q carbon oxide sequestration tax credit incentivizes behaviors under profit-maximizing conditions that could increase rather than decrease GHG emissions in the power sector relative to a counterfactual without the tax credit. Our reply addresses claims that regulatory structures would prevent the negative outcomes we model in the original paper; that our cost and performance assumptions are inaccurate; and that other technologies will see growth. We show that the comment provides no evidence that our original analysis is incorrect and that information that has emerged since the March 2023 publication of our paper supports our assumptions, including public statements by carbon capture project proponents and new information about expected project costs. We agree with Dr. Kennedy that the incentives we highlight where 45Q might incentivize higher emissions at high cost are shocking; we disagree that we have incorrectly characterized these incentives. We share a belief that many of these loopholes can be closed, and disagree that they have already been closed.
Digital and manual interfollicular Ki-67 are associated with a progression-free survival in patients with low-grade follicular lymphoma
Authors: Nasir Aqsa , Hegerova Livia , Yousaf Hira , Forster Colleen L , Shanley Ryan , Linden Michael A , Bachanova Veronika , Yohe Sophia 
Published: December 2023

Abstract

Objectives
Novel histopathologic prognostic factors are needed to identify patients with follicular lymphoma (FL) at risk of inferior outcomes. Our primary objective was to evaluate the Ki-67 proliferative index in follicular and interfollicular areas in tissue biopsy specimens from patients with newly diagnosed FL and correlate with clinical outcomes. Our secondary objective was to correlate PD-L1 and LAG-3 with clinical outcomes.

Methods
Seventy cases of low-grade FL from the University of Minnesota were evaluated with Ki-67 immunohistochemical stain. Ki-67 expression as a continuous variable was interpreted digitally and manually in follicular and interfollicular areas. Progression-free survival (PFS) and overall survival (OS) were analyzed by Cox regression, and hazard ratios (HRs) per 10-point increase in Ki-67 were calculated.

Results
Progression-free survival at 4 years was 28% (95% CI, 19%-41%). Interfollicular, but not follicular, Ki-67 was associated with PFS by manual (HR, 1.33; P = .01) and digital (HR, 1.38; P = .02) analysis. Digital and manual Ki-67 were only moderately correlated but demonstrated similar effects on PFS. At 4 years, OS was 90% with no association with follicular or interfollicular Ki-67 proliferation.

Conclusions
Higher interfollicular Ki-67 by either digital or manual analysis is associated with a poorer PFS in patients with low-grade FL. These results suggest further validation of this marker is warranted to improve pathologic risk stratification at FL diagnosis. PD-L1 and LAG-3 were not associated with PFS or OS.
ASHP and ASHP Foundation Pharmacy Forecast 2024: Strategic Planning Guidance for Pharmacy Departments in Hospitals and Health Systems
Authors: DiPiro Joseph T , Hoffman James M , Schweitzer Pamela , Chisholm-Burns Marie A , Nesbit Todd W , Fabian Tanya J , Cunningham Francesca E , Barrett Alexis , Fine Michael J , Tichy Eric , Hernandez Inmaculada , Scott Christopher M , Norman Christy , Nelson Scott D , Kumah-Crystal Yaa 
Published: December 2023

Abstract
Purpose: The 2024 ASHP Pharmacy Forecast identifies and contextualizes emerging issues and trends that will influence healthcare, health systems, and the pharmacy profession and provides recommendations to inform long-term strategic planning that should prompt action by pharmacists and health-system leaders.
Methods: Drawing on the “wisdom of crowds” concept, a survey was constructed with 6 general themes, each with 6 to 9 focused statements and a seventh theme on preparedness (58 survey items in total). The size of and representation within the survey panel were intended to capture opinions from a wide range of pharmacy leaders. The survey instructed panelists to consider the likelihood of the events/scenarios described in the statements occurring in the next 5 years as being likely, somewhat likely, somewhat unlikely, or very unlikely. Then, survey panelists assessed the preparedness (from very unprepared to very prepared) for 12 of the statements.
Results: The 6 survey themes identified were Urgent Public Health Priorities, Responding to the Mental Health Crisis, Achieving Care Equity, New Disease Paradigms and Treatment Innovations, Workforce: Focus on Culture for the Future, and Artificial Intelligence: Can Ethics and Regulators Catch Up? The survey was completed by 250 respondents, yielding an 88% response rate. Analysis of survey results was provided by chapter authors along with strategic recommendations to guide actions for each theme.
Conclusion: The focus of the Pharmacy Forecast is on large-scale, long-term trends that will influence healthcare and the pharmacy profession over months and years and not on day-to-day situational dynamics. The report provides insight to stimulate thinking and discussion and provides a starting point to proactively position leaders, their teams, and departments for potential future events and trends.
Embedding a Novel Screening Programme for Sexually Transmitted Infections Within an Ambulatory Emergency Surgical Admissions Unit: An Observational Cohort Study
Authors: Ganesh Divolka , Mahon Ciara , Jones Sian , Please Helen , Hughes Mike , Peckham-Cooper Adam 
Published: December 2023

Abstract

Aims
To establish a sexually transmitted infection (STI) screening programme for females presenting to an Emergency Ambulatory Surgical Clinic (ASC), and to analyse incidence and prevalence of STIs as an underlying cause for their abdominal pain.

Methods
Observational cohort study in ASC of a tertiary hospital. Between December 2021 to December 2022, females aged 18-44 years presenting with abdominal pain were offered self-collected vulvovaginal swabs for chlamydia and gonorrhoea as part of a new standardised diagnostic pathway. Positive results were referred to local sexual health services for treatment and contact tracing. Main outcome measures included number of patients consenting to the screening programme and number of positive swab results.

Results
The cohort comprised 297 eligible patients; 259 with 20 patients declining testing and 18 samples rejected. A total of 5.4% of swabs were positive (2 gonorrhoea, 12 chlamydia) with mean age of 24.5. All positive patients presented with lower abdominal pain and of these, only 25% had a documented sexual history during assessment. 7 had further imaging with 4 results diagnosing pelvic inflammatory disease (PID). 4 patients were treated for PID empirically. Remaining patients were treated for non-specific pain or unrelated pathology.

Conclusions
Undiagnosed STIs are prevalent, and have known fertility and public health risks. Young females with lower abdominal pain provide an opportunistic and arguably necessary screening cohort in ASC with good uptake of self-testing. Results demonstrate high incidence of positive tests, suggesting that inclusion of sexual history during assessment is vital to identify those with highest STI risk.