bluuebunny/crossref_metadata_2025_split huggingface dataset:
Experiences of Percutaneous Endoscopic Approach for the Mastoid Lesions: A Novel Minimally Invasive Ear Surgery
Authors: Uchida Masaya , Morioka Shigefumi , Mizutari Kunio 
Published: January 2024

Objectives
We developed a novel keyhole surgery, named “percutaneous endoscopic ear surgery” (PEES), with the aim of further reducing the invasiveness of otologic surgery. We reported the cases we encountered and retrospectively analyzed the invasiveness of PEES.

Methods
We analyzed the ears of eight patients who underwent PEES for mastoid lesions that could not be manipulated with transcanal endoscopic ear surgery (TEES) at our hospital between July 2021 and November 2022. We performed PEES alone in three patients, including one case of type A (preauricular incision) and two cases of type B (retroauricular incision). The last five patients underwent combined endoscopic ear surgery, which is simultaneous PEES and TEES. In these cases, one patient underwent type A PEES, and four patients underwent type B PEES.

Results
PEES was performed in all patients without converting to conventional microscopic mastoidectomy. The mean length of skin incisions was 19.1 ± 4.5 mm, which was smaller than that in conventional mastoidectomy. In all cases, the average length of the major axis of the keyhole was <10 mm, indicating that sufficient minimally invasive surgery was achieved. The average depth from the keyhole to the deepest site was 21.6 ± 8.9 mm. There was no change in the mean hearing level before and after the surgery.

Conclusion
PEES is a minimally invasive procedure for manipulating lesions in the mastoid. In addition, the combination of PEES and TEES is an ideal, minimally invasive procedure that can be used to treat all regions of the temporal bone.
Metabolic failure due to thiamine deficiency during critical illness
Authors: Cobilinschi Cristian , Andrei Cosmin-Andrei , Grinţescu Ioana Marina , Mirea Liliana 
Published: January 2024

Purpose of review
Thiamine is a crucial component in cellular energy metabolism, serving as a cofactor for multiple enzymatic processes and also having a role in regulating neuronal and neuromuscular transmission. Also it exerts antioxidant proprieties. The objective of this review is to consolidate and assess the most recent research concerning the consequences of insufficient thiamine levels for critically ill patients and to examine thiamine-related interventions.

Recent findings
Recent studies have unveiled a noteworthy association between thiamine deficiency and unfavorable consequences, such as heightened morbidity and fatality rates. The aforementioned deficiency exhibits a significant presence in medical situations such as starvation and alcohol use disorder, but also in patients during critical illness. Thiamine deficiency can have significant metabolic implications resulting in compromised energy generation and organ dysfunction, warranting prompt recognition and management.

Summary
Thiamine deficiency may not be recognized in critical care. Timely identification and management are imperative to mitigate adverse outcomes and improve patient prognosis. Thiamine may offer benefits for specific patient groups at higher risk of deficiency. Future studies should focus to establish optimal dosing, timing, and monitoring strategies on understanding the pathophysiological changes associated with thiamine deficiency in ICU patients and clarify its role in improving clinical outcomes.
Bacterial infections in solid organ transplant recipients
Authors: Courjon Johan , Neofytos Dionysios , van Delden Christian 
Published: January 2024

Purpose of review
Bacteria are the leading cause of infections in solid organ transplant (SOT) recipients, significantly impacting patient outcome. Recently detailed and comprehensive epidemiological data have been published.

Recent finding
This literature review aims to provide an overview of bacterial infections affecting different types of SOT recipients, emphasizing underlying risk factors and pathophysiological mechanisms.

Summary
Lung transplantation connects two microbiotas: one derived from the donor's lower respiratory tract with one from the recipient's upper respiratory tract. Similarly, liver transplantation involves a connection to the digestive tract and its microbiota through the bile ducts. For heart transplant recipients, specific factors are related to the management strategies for end-stage heart failure based with different circulatory support tools. Kidney and kidney–pancreas transplant recipients commonly experience asymptomatic bacteriuria, but recent studies have suggested the absence of benefice of routine treatment. Bloodstream infections (BSI) are frequent and affect all SOT recipients. Nonorgan-related risk factors as age, comorbidity index score, and leukopenia contribute to BSI development. Bacterial opportunistic infections have become rare in the presence of efficient prophylaxis. Understanding the epidemiology, risk factors, and pathophysiology of bacterial infections in SOT recipients is crucial for effective management and improved patient outcomes.
Correlation of fatigue on walking ability in myasthenia gravis patients: a cross-sectional study
Authors: Kartika Lisa , Subadi Imam , Pawana I Putu Alit , Andriana Meisy , Sugianto Paulus 
Published: January 2024

Introduction:Myasthenia gravis (MG) is a neuromuscular junction autoimmune disease characterised of intermittent muscle weakness that increases with activity and recovers with rest.Objective:Analysing the correlation of fatigue on walking ability in MG patients.Methods:This study used a cross-sectional design with consecutive sampling. Participants MG patients took in this trial. Data collection encompasses fatigue and walking ability, with fatigue being assessed using the fatigue severity scale (FSS) and walking ability being assessed using the 10-metre walking test. The 10-metre walking test assessment contains three components: comfortable walking speed (CWS), maximum walking speed (MWS), and natural cadence. The statistical analysis used in this study includes the Pearson correlation and Spearman rank tests withP<0.05.Results:The number of participants was 23 MG patients, and most of the participant was female (69.6%). The participant’s fatigue value was 5.46±1.13, including MGFA 1=5.32±1.15, MGFA 2A=5.5±1.11, and MGFA 2B=5.61±1.30. Meanwhile, the participant’s walking abilities included CWS of 1.10±0.11 m/s, MWS of 1.31±0.15 m/s, and natural cadence of 110.91±7.74 steps/min. No significant correlation of fatigue on walking ability including FSS vs. CWS (r=−0.141;P=0.520), FSS vs MWS (r=−0.169;P=0.442), and FSS vs. natural cadence (r=−0.050;P=0.822).Conclusion:There was no significant correlation between fatigue and walking ability in MG patients who had MGFA 1, MGFA 2A, and MGFA 2B.
Adult-to-adult right lobe graft living donor liver transplantation for acute-on-chronic liver failure: a single-centre retrospective study in Vietnam
Authors: Vu Quang V. , Le Thanh V. , Le Hieu T. , Nguyen Anh H N. , Nguyen Duy T. 
Published: January 2024

Introduction:
Acute-on-chronic liver failure (ACLF) has a high mortality rate, and liver transplantation is considered a definite treatment for patients with this condition. This study aims to evaluate the outcomes of living donor liver transplantation (LDLT) in ACLF patients in a single centre in a lower middle-income country, Vietnam.

Materials and methods:
This was a retrospective study at the 108 Military Central Hospital (Hanoi, Vietnam), enroling 51 patients diagnosed with ACLF based on Asian Pacific Association for the Study of the Liver (APASL) criteria who underwent LDLT with a right lobe graft from December 2019 to December 2022. The authors utilize the model for end-stage liver disease (MELD) and APASL ACLF Research Consortium (AARC) scores to evaluate and stratify the severity of ACLF.

Results:
The average age of all patients was 47.27±13.61, with 88.24% being male. The average BMI was 22.78±2.61. The most common underlying liver disease was chronic viral hepatitis B (88.2%). The average MELD score of the patients was 34.90±5.61, with 33.3% having MELD score greater than or equal to 40. In terms of ACLF severity, five patients (9.8%) had grade I ACLF, 35 patients (68.6%) had grade II ACLF, and 11 patients (21.6%) had grade III ACLF. The average AARC score was 9.43±1.68. The duration of treatment in the ICU was 8.59±7.27 days, and the length of hospital stay was 28.02±13.45 days. The most common post-transplant complication was biliary complication (19.61%). Death occurred in 7 patients (13.7%). The survival rates at 6 months, 1 year, and 3 years were 84%, 81.7%, and 81.7%, respectively.

Conclusion:
Living donor liver transplantation for ACLF patients is safe and has a high post-transplant survival rate. Multidisciplinary care before, during, and after surgery, and the decision to do a liver transplant early, is essential in saving the lives of ACLF patients.
Differential Characteristics of Fatigue–Pain–Sleep Disturbance–Depression Symptom Cluster and Influencing Factors of Patients With Advanced Cancer During Treatment
Authors: Ye Yanxin , Zeng Kai , Qin Lan , Luo Jiahui , Liu Suting , Miao Jingxia , Liang Jingwen , Yu Ya , Zhao Ming , Zhang Lili 
Published: January 2024

Background
Patients with advanced cancer may experience symptom clusters during treatment (eg, fatigue, pain, sleep disturbance, depression). Understanding the characteristics and factors associated with symptom cluster classes among this patient population is essential for effective symptom management.

Objective
The aims of this study were to identify symptom cluster (fatigue–pain–sleep disturbance–depression) classes and explore influencing factors in patients with advanced cancer during the treatment.

Methods
A cross-sectional survey was conducted in an oncology department of a tertiary hospital in China from September 2020 to March 2021. Cancer patients (stage III/IV) 18 years or older completed the questionnaires on pain, fatigue, sleep disturbance, depression, physical activity, and exercise self-efficacy. Latent class analysis and multinomial logistic regression were used.

Results
Three hundred sixty-five patients who were male (65.2%) and younger than 60 years (59.5%) completed questionnaires. Three symptom cluster classes were identified: class 1 (“low symptom burden” class), class 2 (“fatigue-insomnia” class), and class 3 (“high symptom burden” class), with a percentage of 54.5%, 38.6%, and 6.8%, respectively. The quality-of-life score, introversion/extroversion, economic burden, Karnofsky Performance Status, albumin level, and exercise self-efficacy were significantly different among the 3 classes (P < .05).

Conclusion
Patients with advanced cancer were classified into 3 distinct classes, with class 1 having the best function. Results from this study reveal that Karnofsky Performance Status, albumin level, and exercise self-efficacy were significant factors for the latent classes of symptom cluster.

Implications for Practice
Exercise self-efficacy is important for personalized interventions and improving symptom management efficiency.
Frostbite in the Pediatric Population
Authors: Ma Xiya , Pouoh Jamilah Temfack , Hogue Bénédicte Therrien , Bougie Emilie 
Published: January 2024

Introduction
Frostbite in the pediatric population, where skeletal maturity has not been achieved, can have important repercussions on subsequent growth. Yet, the optimal management of frostbite injuries in children remains vague. This review aims to summarize the current evidence for frostbite management in children and understand Canadian practice trends on this topic.

Methods
A review using Medline, Scopus, Web of Science, and gray literature was performed to identify relevant literature on the clinical manifestations, diagnostic methods, and treatment options in pediatric frostbite. An online survey was sent to plastic surgeons through the Canadian Society of Plastic Surgeons (CSPS) mailing list to further identify national practices and trends for pediatric frostbite management.

Results
A total of 109 articles were reviewed. No article provided a specific algorithm for pediatric frostbite, with existing recommendations suggesting the use of adult guidelines for treating children. Our survey yielded 9 responses and highlighted the rarity of pediatric frostbite cases, with no responder treating more than 10 cases per year. Most (55.6%) do not use a pediatric-specific treatment algorithm, whereas 30% apply adult guidelines. A conservative approach focusing on rewarming (55.6%), limb elevation (50%), and tetanus status verification (66.7%) was predominant. Imaging and surgical interventions seem to be reserved for severe cases.

Conclusions
The current literature for pediatric frostbite management lacks specificity. Canadian practices vary, with a trend toward a conservative approach. The limited evidence and rarity of experience highlight the need for further research, ideally in a collaborative multicentric manner, to create a consensus for pediatric frostbite care.
Factors Predisposing Patients to Non-Home Discharge After Surgery for Degenerative Cervical Myelopathy: A Retrospective Analysis
Authors: Callaghan-VanderWall Megan E. , Kuo Andy , Baumann Anthony N. , Furey Christopher G. , Cheng Christina W. 
Published: January 2024

Abstract

Objective
The objective of this study is to evaluate factors associated with discharge to subacute care after surgery for degenerative cervical myelopathy (DCM).

Design
This is a retrospective chart review of adults who underwent cervical spine surgery at a for DCM between 2014 and 2020 (n = 135).

Results
Patients discharged to a subacute setting were older (68.1 +/- 8.6 vs. 64.1 years +/- 8.8; p = 0.01); more likely to be unmarried (55.8% vs. 33.7% married; p = 0.01); and more likely to have Medicare or Medicaid (83.7% vs. 65.9% private insurance; p = 0.03). than patients discharged home. A posterior surgical approach was associated with discharge to a subacute setting (62.8% vs. 43.5% anterior approach; p = 0.04). 87.8% of patients discharged to a subacute setting required moderate or maximum assistance for bed mobility vs. 26.6% of patients discharged home (p < 0.0001).Compared to patients discharged home, patients discharged to a subacute setting ambulated a shorter distance in their first Physical Therapy Evaluation after surgery (8.9 meters +/- 35.8 vs. 53.7 meters +/- 61.78 in the home discharge group; p < 0.0001).

Conclusion
Analysis of these factors may guide discussions about patient expectations for postoperative discharge placement.
Clinical Applications of Tranexamic Acid in Plastic and Reconstructive Surgery
Authors: Brown Stav , Brown Tal , Rohrich Rod J. 
Published: January 2024

Background:
Tranexamic acid (TXA) has gained increasing recognition as a valuable pharmacologic agent within plastic surgery. This study reviews the scientific evidence regarding the use of TXA in the full range of plastic and reconstructive surgery to provide clinical recommendations for safe and effective use in various plastic surgical procedures.

Methods:
A systematic review and meta-analysis were conducted following the Preferred Reporting Items for Systematic Reviews and Meta-Analysis guidelines. An established appraisal process was used to rate the quality of articles (Grading of Recommendations Assessment, Development, and Evaluation methodology).

Results:
Forty-five studies describing the use of TXA in plastic surgery were included. There is moderate-certainty evidence to support the use of intravenous administration of TXA in craniofacial surgery procedures to reduce blood loss and transfusion requirements. There is high-certainty evidence to support the use of TXA in cosmetic surgery and intravenous administration in rhinoplasty procedures to reduce blood loss. Further high-level studies are needed to determine TXA’s effects on hematoma rates in face-lift surgery and breast-related procedures. There is moderate-certainty evidence to support the use of TXA in burn care. Further studies are required to provide quantitative conclusions on the effects of TXA administration in microsurgery.

Conclusions:
This is the largest study to date on the use of TXA in plastic surgery and the first to provide clinical recommendations. The literature highlights TXA’s promising role in the fields of craniofacial surgery, cosmetic surgery, and burn care. Standardized, objective measurements are required to provide quantitative conclusions regarding TXA’s effects on ecchymoses and edema in cosmetic surgery procedures.
Use of MRI in patients with severe diffuse traumatic brain injury: a matched National Trauma Data Bank analysis
Authors: Chilakapati Sai , Dragun Anthony J. , Chiu Ryan G. , George Keith M. , Valadka Alex B. 
Published: January 2024

ABSTRACT

Objective
MRI is increasingly used to evaluate patients with diffuse traumatic brain injury (dTBI). However, the utility of early MRI is understudied. We hypothesize that early MRI patients will have increased length of stay but no changes in ICP management or disposition.

Methods
The 2019 NTDB was queried for patients with dTBI and Glasgow Coma Scale score ≤ 8. Extra-axial and focal intra-axial hemorrhages were excluded. Clinical characteristics were controlled for. Patients with and without MRI were compared for ICP management, outcome, mortality, and disposition. A propensity score matching algorithm was used to create a 1:1 match cohort.

Results
In 2568 patients, MRI was less common in severe dTBI patients with clear reasons for poor exam, including bilaterally unreactive pupils or midline shift. After matching, 501 patients who underwent MRI within one week were compared to 501 patients without MRI. MRI patients had longer ICU stays (11.6 ± 9.6 vs. 13.4 ± 9.5, p < 0.01 [-3.03, -0.66 95% CI]). There was no difference between groups in ICP monitor (23.6% vs. 27.3%, p = 0.17 [-0.09, 0.02 95% CI]) or ventriculostomy placement (13.6% vs. 13.2%, p = 0.85 [-0.04, 0.05 95% CI]) or in withdrawal of care (15.0% versus 18.6%, p = 0.12 [-0.08, 0.01 95% CI]). MRI patients were more likely to be discharged to inpatient rehabilitation (42.9% vs. 33.5%, p < 0.01 [0.03, 0.15 95% CI]) but not to home (9.4% versus 9.0 %, p = 0.83 [-0.03, 0.04 95% CI]).

Conclusions
The decision to pursue early brain MRI may be driven by lack of obvious reasons for a patient’s poor neurologic status. MRI patients had longer ICU stays but no difference in rates of placement of ICP monitors or ventriculostomies or withdrawal of care. Further study is required to define the role of early MRI in dTBI patients.

Level of evidence
Prognostic/epidemiological, IV
Infection and Prophylaxis During Normothermic Liver Perfusion: Audit of Incidence and Pharmacokinetics of Antimicrobial Therapy
Authors: Qureshi Saeed , Elliott Heather , Noel Alan , Swift Lisa , Fear Corrina , Webster Rachel , Brown Nicholas M. , Gaurav Rohit , Butler Andrew J. , Watson Christopher J. E. 
Published: January 2024

Background.
Ex situ normothermic liver perfusion (NMP) in a blood-based perfusate is associated with a risk of microbe growth, resulting in life-threatening posttransplant sepsis. Antibiotics are widely used, but the pharmacokinetics of these agents are unknown as is their efficacy. We wished to assess the perfusate concentrations of the meropenem and fluconazole that we use and to audit the incidence of infection with this antimicrobial therapy.

Methods.
Fluconazole and meropenem (100 mg each) were added to the perfusate before NMP began, and serial samples were taken and assayed for drug concentrations. Perfusate cultures were available from 210 of the 242 perfusions performed between February 1, 2018, and April 6, 2023; these were reviewed.

Results.
Following administration of 100 mg fluconazole, levels fell slightly from a median of 24.9 mg/L at 1 h to 22.6 mg/L at 10 h. In contrast, meropenem concentrations fell over time, from a median of 21.8 mg/L at 1 h to 9.4 mg/L at 10 h. There were 4 significant microorganisms grown in the perfusions, including 3 Candida species and an Enterococcus faecium. All the Candida-infected livers were transplanted with no adverse consequences, the recipients being treated with anidulafungin upon identification of the infecting organism; the Enterococcus-infected liver was not transplanted.

Conclusions.
Serious infection is a risk with NMP but appears to be mitigated with a protocol combining fluconazole and meropenem. This combination may not be appropriate in areas where resistance is prevalent. Routine culture of NMP perfusate is essential to identify breakthrough organisms early and enable recipient treatment.
Effects of changes in calculating GFR using KDIGO standards: Discordance in the Staging and Timing of Diagnosis of Chronic Kidney Disease
Authors: Baker Charlotte , Gratzl Samuel , Rodriguez Patricia J , Simonov Michael , Cartwright Brianna M Goodwin , Brar Rajdeep , Stucky Nicholas L 
Published: January 2024

AbstractIntroductionChronic kidney disease (CKD) is a highly prevalent disease with disparities in diagnosis and treatment. Until recently, primary diagnosis for CKD was based on equations that incorporated race and have demonstrated racial bias. This study had two aims comparing outcomes for Black patients and their counterparts: 1) whether using the new 2021 CKD-EPI equation led to decreased disparity with time to diagnosis; and 2) whether there was discordance in the staging between the two equations at potential diagnosis point.MethodsWe evaluated patients aged 18 and over with non-hospitalization related serum creatinine laboratory results between January 1, 2016 and September 30, 2023. We estimated the GFR for each patient using the 2009 and 2021 CKD-EPI creatinine equations. We assessed stage discordance for stages 3a, 3b, 4, and 5 using chi-square tests and the Cochran-Mantel-Haenszel. We used multivariate logistic regression to assess a change in staging based on the equation used.Results15.5% of the 8,080,889 patients included in this study were Black. The median age was 57 years and 15.3% of patients met the criteria for stage 3a CKD or higher using either equation. Discordance in staging by equation and by race existed, especially for Black patients at stages 3a and 3b. 40% of Black patients identified as stage 4 using the 2021 equation were 3b or lower using the 2009 equation.DiscussionWell established medical algorithms with race components are being re-examined. We found more disparity with the initial staging of the disease. The disconnect in the timing of staging by equation for Black patients means a number of these patients may not have received the appropriate treatment. Future work should elucidate the impact of the change in CKD staging with the 2021 CKD-EPI creatinine equation on treatment.ConclusionSignificant disparity exists in the timing and staging of CKD by CKD-EPI equation and by race.