bluuebunny/crossref_metadata_2025_split huggingface dataset:
Experimental designs for controlling the correlation of estimators in two‐parameter models
Authors: Benitez Edgar , López‐Fidalgo Jesús 
Published: November 2023

AbstractThe state of the art related to parameter correlation in two‐parameter models has been reviewed in this paper. The apparent contradictions between the different authors regarding the ability of D‐optimality to simultaneously reduce the correlation and the area of the confidence ellipse in two‐parameter models were analyzed. Two main approaches were found: (1) those who consider that the optimality criteria simultaneously control the precision and correlation of the parameter estimators and (2) those that consider a combination of criteria to achieve the same objective. An analytical criterion combining in its structure both the optimality of the precision of the estimators of the parameters and the reduction of the correlation between their estimators is provided. The criterion was tested both in a simple linear regression model, considering all possible design spaces, and in a nonlinear model with strong correlation of the estimators of the parameters (Michaelis–Menten) to show its performance. This criterion showed a superior behavior to all the strategies and criteria to control at the same time the precision and the correlation.
Enantioselective Synthesis of Biphenyl‐Bridged ϵ‐Sultams by Organocatalytic Mannich Reactions of Cyclic N‐Sulfonylimines with Unactivated Ketones
Authors: Du Ying , Li Qian , Wang Tao , Wang You‐Qing 
Published: November 2023

AbstractA highly enantioselective Mannich reaction of biphenyl‐bridged seven‐membered cyclic N‐sulfonylimines with methyl alkyl ketones is disclosed in this study. The reaction was performed under organocatalysis by using a quinine‐derived primary amine as the catalyst in combination with a Brønsted acid as the co‐catalyst. High yields (up to 89 %) and excellent enantioselectivities (up to 97 % ee) were observed. For methyl alkyl ketones containing a larger alkyl substituent, specific regioselective addition to the C=N bond is favored at the methyl group. On the contrary, ketones containing a smaller alkyl substituent or hydroxyacetone substrates gave major syn selective Mannich products at the methylene group.
2‐Pyridone Formation: An Efficient Method for the Solid‐Phase Synthesis of Homodimers
Authors: Abboud Skander A. , Kodadek Thomas 
Published: November 2023

AbstractThis study presents an efficient method for on‐resin dimer generation through self‐condensation of 3,3‐dimethoxypropionic acid‐modified molecules, resulting in 2‐pyridones. The approach demonstrated remarkable versatility by producing homodimers of peptides, peptoids, and non‐peptidic ligands. Its ease of application, broad utility, and mild reaction conditions not only hold significance for peptide and peptoid research but also offer potential for the on‐resin development of a wide range of bivalent ligands.
Ablation versus medical therapy for patients with atrial fibrillation: An updated meta‐analysis
Authors: Kheshti Fatemeh , Abdollahifard Saeed , Hosseinpour Alireza , Bazrafshan Mehdi , Attar Armin 
Published: November 2023

AbstractTo investigate the effect of ablation compared to medical therapy on clinical outcomes of patients with atrial fibrillation (AF). PubMed, Scopus, Embase, and Web of Science databases were searched using ablation, medical treatment, AF, and related words. The effect of ablation and medical therapy was sought to be gathered on stroke or transitional ischemic attack, mortality, hospitalization, recurrence of AF, progression of AF, and left ventricular ejection fraction. Analyses were performed using R software. 31 studies (the results of 27 randomized controlled trials), compromising an overall 6965 patients (Ablation, n = 3643; Medical treatment, n = 3322) were reviewed in our study, revealed that catheter ablation would result in substantial benefits for patients with AF without significant difference in serious adverse events compared to medical management (Risk Ratio: 0.92, [95% Confidence Interval (CI), 0.64−1.33]). Catheter ablation in patients with AF significantly resulted in a 29% reduction in all‐cause mortality (RR: 0.71, [95% CI, 0.57−0.88]), a 57% reduction in hospitalization (RR: 0.43, [95% CI, 0.27−0.67]), a 53% reduction in AF recurrence (RR: 0.47, [95% CI, 0.36−0.61]), and a dramatic reduction, 89%, in progression of paroxysmal to persistent AF (RR: 0.11, [95% CI, 0.02−0.65]); also associated with a remarkable improvement in their left ventricular ejection fraction (LVEF) (Mean Difference, MD: 6.84%, [95% CI, 3.27−10.42]) compared to medical therapy. Our study showed that ablation may be superior to medical therapy in patients with AF regarding AF recurrence, mortality, LVEF improvement, hospitalization, and AF progression outcomes.
Topography of visual and somatosensory inputs to the pontine nuclei in zebra finches (Taeniopygia guttata)
Authors: Gaede Andrea H. , Gutiérrez‐Ibáñez Cristián , Wu Pei‐Hsuan , Pilon Madison C. , Altshuler Douglas L. , Wylie Douglas R. 
Published: November 2023

AbstractBirds have a comprehensive network of sensorimotor projections extending from the forebrain and midbrain to the cerebellum via the pontine nuclei, but the organization of these circuits in the pons is not thoroughly described. Inputs to the pontine nuclei include two retinorecipient areas, nucleus lentiformis mesencephali (LM) and nucleus of the basal optic root (nBOR), which are important structures for analyzing optic flow. Other crucial regions for visuomotor control include the retinorecipient ventral lateral geniculate nucleus (GLv), and optic tectum (TeO). These visual areas, together with the somatosensory area of the anterior (rostral) Wulst, which is homologous to the primary somatosensory cortex in mammals, project to the medial and lateral pontine nuclei (PM, PL). In this study, we used injections of fluorescent tracers to study the organization of these visual and somatosensory inputs to the pontine nuclei in zebra finches. We found a topographic organization of inputs to PM and PL. The PM has a lateral subdivision that predominantly receives projections from the ipsilateral anterior Wulst. The medial PM receives bands of inputs from the ipsilateral GLv and the nucleus laminaris precommisulis, located medial to LM. We also found that the lateral PL receives a strong ipsilateral projection from TeO, while the medial PL and region between the PM and PL receive less prominent projections from nBOR, bilaterally. We discuss these results in the context of the organization of pontine inputs to the cerebellum and possible functional implications of diverse somato‐motor and visuomotor inputs and parcellation in the pontine nuclei.
Sodium Alginate/Zwitterionic Polymer Gel Electrolyte for Integrated All‐Solid‐State Supercapacitors
Authors: Hou Zhaoxia , Wang Haoran , Wang Kai 
Published: November 2023

AbstractAll‐solid‐state stretchable supercapacitors (SSSCs) have attracted widespread attention in the wearable and medical fields because of their nontoxic, safe, and environmentally friendly characteristics. In this paper, a dual network hydrogel polymer was synthesized by a one‐pot method, which was constructed from sodium alginate (SA) and zwitterion copolymer of acrylamide (AM) and sulfobetaine methacrylate (SBMA). The dual network hydrogel polymerSAm/P(AM‐co‐SBMA (SASm for short) were immersed in 1 M H2SO4 electrolyte to obtain gel polymer electrolytes (GPEs). Stretchable electrodes were synthesized on the matrix of SASm gels. Non‐integrated all‐solid‐state stretchable supercapacitors (non‐integrated SSSCs), integrated all‐solid‐state supercapacitors (SSCs) and integrated SSSCs were all assembled into the ‘sandwich’ structure. The elongation of the integrated SSSC is the best and reaches 280 %, and its areal capacitance is 1.96 mF/cm2 under a current destiny of 50 μA/cm2, and the capacitance still remains 95 % of the initial value after 10000 charge and discharge cycles, and its energy density is 5.8×10−2 μWh/cm2 at a power density of 2.9×10−2 mW/cm2. This integrated SSSC has excellent cycling stability while maintaining good tensile properties.
Furandicarboxylate Polyesters: A Comprehensive ADMET Study of a Novel Class of Furan‐Based α,ω‐Diene Monomers
Authors: Chícharo Beatriz , Fadlallah Sami , Allais Florent , Aricò Fabio 
Published: November 2023

AbstractThe present research article delves into the preparation of a new class of bio‐based polyesters from α,ω‐diene furandicarboxylate monomers. In particular, it exploits the use of acyclic diene metathesis polymerisation (ADMET) on 2,5‐furandicarboxylic acid (FDCA)‐derived compounds. First, a library of furan‐based α,ω‐diene monomers was prepared via acid‐ or base‐catalyzed transesterification of 2,5‐furandicarboxylic acid dimethyl ester (FDME) with commercially available alcohols incorporating terminal olefins, i. e., allyl alcohol, but‐3‐en‐1‐ol, hex‐5‐en‐1‐ol and dec‐9‐en‐1‐ol. Then, the novel monomers were subjected to ADMET polymerisation employing different catalysts and reaction conditions. Interestingly, first‐generation Grubbs catalyst was found to be the best promoter for ADMET polymerisation. This catalyst allowed the preparation of a new family of bio‐based polyesters with molecular weights up to 26.4 kDa, with good thermal stability, and adaptable cis‐trans conformations. Results also revealed that the monomer structure had a direct impact on the polymerisation efficiency and the resulting thermal properties. The effect of green bio‐based solvents such as Cyrene™, dimethyl isosorbide (DMI) and γ‐valerolactone (GVL) on the polymerisation process was also studied. Data collected showed that the solvent concentration influenced both the yield and length of polymers formed. Furthermore, some co‐polymerisation experiments were conducted; the successful integration of different monomers in the resulting copolymer was shown to affect the glass transition temperature (Tg) of the resulting materials.
Phenotyping patients with ischaemic heart disease at risk of developing heart failure: an analysis of the HOMAGE trial
Authors: Santos‐Ferreira Diogo , Diaz Sílvia O. , Ferreira João Pedro , Girerd Nicolas , Pellicori Pierpaolo , Mariottoni Beatrice , Cosmi Franco , Hazebroek Mark , Verdonschot Job A.J. , Cuthbert Joe , Petutschnigg Johannes , Heymans Stephane , Staessen Jan A. , Pieske Burkert , Edelmann Frank , Clark Andrew L. , Rossignol Patrick , Fontes‐Carvalho Ricardo , Cleland John G.F. , Zannad Faiez 
Published: November 2023

AbstractAimsWe aim to characterize the clinical and proteomic profiles of patients at risk of developing heart failure (HF), with and without coronary artery disease (CAD) or prior myocardial infarction (MI).Methods and resultsHOMAGE evaluated the effect of spironolactone on plasma and serum markers of fibrosis over 9 months of follow‐up in participants with (or at risk of having) CAD, and raised natriuretic peptides. In this post hoc analysis, patients were classified as (i) neither CAD nor MI; (ii) CAD; or (iii) MI. Proteomic between‐group differences were evaluated through logistic regression and narrowed using backward stepwise selection and bootstrapping. Among the 527 participants, 28% had neither CAD or MI, 31% had CAD, and 41% had prior MI. Compared with people with neither CAD nor MI, those with CAD had higher baseline plasma concentrations of matrix metalloproteinase‐7 (MMP‐7), galectin‐4 (GAL4), plasminogen activator inhibitor 1 (PAI‐1), and lower plasma peptidoglycan recognition protein 1 (PGLYRP1), whilst those with a history of MI had higher plasma MMP‐7, neurotrophin‐3 (NT3), pulmonary surfactant‐associated protein D (PSPD), and lower plasma tumour necrosis factor‐related activation‐induced cytokine (TRANCE). Proteomic signatures were similar for patients with CAD or prior MI. Treatment with spironolactone was associated with an increase of MMP7, NT3, and PGLYRP1 at 9 months.ConclusionsIn patients at risk of developing HF, those with CAD or MI had a different proteomic profile regarding inflammatory, immunological, and collagen catabolic processes.
Neuropeptide Y is elevated in heart failure and is an independent predictor of outcomes
Authors: McDowell Kirsty , Adamson Carly , Jackson Colette , Campbell Ross , Welsh Paul , Petrie Mark C. , McMurray John J.V. , Jhund Pardeep S. , Herring Neil 
Published: November 2023

AbstractAimsNeuropeptide Y (NPY) is the most abundant neuropeptide found in the heart and is released alongside norepinephrine following prolonged sympathetic activation, a process that is implicated in the pathophysiology of heart failure (HF). In patients with severely impaired left ventricular ejection fraction (LVEF) undergoing cardiac resynchronization therapy, higher levels of NPY measured in coronary sinus blood, are associated with poorer outcome. The aim was to examine the association of peripheral venous NPY levels and outcomes in a HF population with a range of LVEF, using a highly sensitive and specific assay.Methods and resultsThe association between NPY and the composite outcome of cardiovascular death or HF hospitalization, its components, and all‐cause mortality was examined using Cox regression analyses among 833 patients using a threshold of elevated NPY identified through binary recursive partitioning adjusted for prognostic variables including estimated glomerular filtration rate (eGFR), ejection fraction and B‐type natriuretic peptide (BNP). The mean value of NPY was 25.8 ± 18.2 pg/ml. Patients with high NPY levels (≥29 pg/ml) compared with low values were older (73 ± 10 vs. 71 ± 11 years), more often male (58.5% vs. 55.6%), had higher BNP levels (583 [261–1096] vs. 440 [227–829] pg/ml), lower eGFR (46.4 ± 13.9 vs. 52.4 ± 11.7 ml/min/1.73 m2), and were more often treated with diuretics. There was no associated risk of HF hospitalization with NPY levels ≥29 vs. <29 pg/ml. Higher NPY levels were associated with a greater risk of cardiovascular and all‐cause death (adjusted hazard ratio 1.56 [95% confidence interval 1.21–2.10], p = 0.003 and 1.30 [1.04–1.62], p = 0.02, respectively). There was no associated risk of HF hospitalization with higher NPY levels.ConclusionsPeripherally measured NPY is an independent predictor of all‐cause and cardiovascular death even after adjustment for other prognostic variables, including BNP.
The IFN‐γ‐CXCL9/CXCL10‐CXCR3 axis in vitiligo: Pathological mechanism and treatment
Authors: Liu Hanqing , Wang Yihui , Le Qianqian , Tong Jiajia , Wang Honglin 
Published: November 2023

AbstractVitiligo is a disease featuring distinct white patches that result from melanocyte destruction. The overall pathogenesis of vitiligo remains to be elucidated. Nevertheless, considerable research indicates that adaptive immune activation plays a key role in this process. Specifically, the interferon‐gamma (IFN‐γ), C‐X‐C motif chemokine ligands (CXCL9/10), and C‐X‐C motif chemokine receptor (CXCR3) signaling axis, collectively referred to as IFN‐γ‐CXCL9/10‐CXCR3 or ICC axis, has emerged as a key mediator responsible for the recruitment of autoimmune CXCR3+ CD8+ T cells. These cells serve as executioners of melanocytes by promoting their detachment and apoptosis. Moreover, IFN‐γ is generated by activated T cells to create a positive feedback loop, exacerbating the autoimmune response. This review not only delves into the mechanistic insights of the ICC axis but also explores the significant immunological effects of associated cytokines and their receptors. Additionally, the review provides a thorough comparison of existing and emerging treatment options that target the ICC axis for managing vitiligo. This review aims to foster further advancements in basic research within related fields and facilitate a deeper understanding of alternative treatment strategies targeting different elements of the axis.
Hydrophosphorylation of C=O/N Bonds Using Organophosphine Oxides or Sulfides
Authors: Lamberink‐Ilupeju Jan‐Willem , Ragogna Paul J. , Blacquiere Johanna M. 
Published: November 2023

Abstractα‐Functionalized phosphorus compounds are an important class of biologically relevant molecules. The synthesis of these compounds often proceeds through the hydrophosphorylation of a C=E bond, with the most well‐known transformation being the Kabachnik‐Fields reaction. The nature of the phosphorus reagent is an important aspect of the hydrophosphorylation reaction. The Kabachnik‐Fields reaction uses H‐phosphonates (RO)2P(O)H, and similarities are often applied to 2° phosphine chalcogenides (R2P(Ch)H). However, the reactivities of the P−C and P−OR molecules differ quite dramatically, which changes the operative mechanism as well as subsequent downstream chemistry. We provide an in‐depth analysis of hydrophosphorylation of C=E (E=O, N) bonds with organophosphine chalcogenides. Additional discussion and a critical appraisal are provided on the similarities and differences between the H‐phosphonate and phosphine chalcogenide chemistry.
Mind the gap: Wise reasoning attenuates gender pay gap scepticism in men
Authors: Brienza Justin P. , Dorfman Anna , Bobocel D. Ramona 
Published: November 2023

AbstractWe draw from theory on motivated reasoning to suggest that men would be more prone toward gender pay gap scepticism (PGS) than women because doing so maintains a valued but illusory belief that society is currently fair. Integrating theory on wisdom and wise reasoning—a self‐transcendent thinking process composed of intellectual humility, contextualism, perspectivism and dialecticism—we also hypothesised that men who engaged in stronger (vs. weaker) wise reasoning about the pay gap would be less prone toward PGS. Two pre‐registered studies (N = 651) supported the predictions: generally, men were more prone toward gender PGS than women, while wise reasoning tended to attenuate scepticism in men. The patterns of effects remained stable when controlling for income, education, political orientation, and perceptions of the effects of COVID‐19 on women's economic and psychological well‐being. Our studies pave the way for interventions that alter how people reason about inequities such as the gender pay gap in an effort to create fairer workplaces and societies.
Navigating non‐normative roles: Experiences of female‐breadwinning couples in Pakistan
Authors: Shah Rahat 
Published: November 2023

AbstractThis study aims to explore the experiences of female‐breadwinning couples (FBCs) in Pakistan. Using the constructivist grounded theory approach, a sample of twenty participants (10 male and 10 females) was interviewed. The study findings show that FBCs experience social stigmatisation, social isolation and differential treatment. These couples are viewed as abnormal, different and violators of the normative gendered expectations. FBCs not only experience societal backlash, but their relationship dynamics are also negatively affected. To deal with societal responses and relationship problems, these couples adopt various normalisation strategies such as exercising discretion, relocation and performing gender identities. This study contributes to the literature by providing a culturally informed perspective on how deeply embedded gender norms shape interpersonal dynamics, normalisation strategies and overall experiences with non‐normative roles. The study also suggests for a more explicit consideration of cultural and normative contexts to enrich the application of social psychological theories.
Novel prediction models of earthquake early warning for ground motion power in Taiwan
Authors: Chao Shu‐Hsien , Lin Che‐Min , Chou Chung‐Che , Chen Kuan‐Hua 
Published: November 2023

AbstractStudies have indicated that the power of seismic waves, rather than the acceleration and velocity, strongly correlates with the level of structural damage and the shutdown of high‐tech equipment during high‐precision process. However, current earthquake early warning (EEW) systems in Taiwan issue a warning only for a seismic wave with high acceleration or velocity but not for that with high power. To extend the application of the EEW system to high‐tech fields, conventional and novel hybrid prediction models were developed in this study to predict the ground motion power and to issue EEWs for high‐power ground motions. A conventional prediction model that relies on earthquake source parameters was first developed to determine ground motion characteristics, and a hybrid prediction model that relies not only on earthquake source parameters but also on the on‐site ground motion parameter of P‐waves was developed to improve the prediction accuracy. The two‐step maximum likelihood method was used to derive model coefficients for considering the mixed effect of the ground motion records. The source, path, and site effects on the short‐period power and the long‐period power of ground motions were illustrated by the proposed models. A method for determining a broadcast scenario of EEW systems for high‐power ground motions with a target success rate and damage threshold was also developed. These novel prediction models can be used to develop a customized EEW system to provide an early warning for high‐power seismic waves in Taiwan.
Chemical components of Fu brick tea and its potential preventive effects on metabolic syndrome
Authors: Li Honghua , Dai Wei , Zhang Xinjun , Lu Jie , Song Fuhang , Li Hua 
Published: November 2023

AbstractAs living standards advance, an escalating emphasis is placed on health, particularly in relation to prevalent chronic metabolic disorders. It is necessary to explore safe and effective functional foods or drugs. Fu brick tea (FBT) is a kind of dark tea fermented by fungi. The extracts are rich in compounds that can effectively relieve metabolic diseases such as hyperglycemia and hyperlipidemia, protect the liver, improve human immunity, enhance antioxidant activity, and regulate intestinal flora. This paper summarizes the biological activities and mechanisms of the extracts, polysaccharides, and small molecular compounds of FBT, which provides a certain theoretical basis for the rational, systematic, comprehensive development and utilization of the FBT resources. It is expected to develop and apply these active substances in health care products and natural medicines and provide more beneficial and diversified FBT products for human beings.