bluuebunny/crossref_metadata_2025_split huggingface dataset:
Dapagliflozin did not increase in serum K in advanced CKD in spite of initial eGFR decline
Authors: Mitani Waka , Iwata Yukimasa , Kobayashi Midori , Notsu Shoki , Morimoto Madoka , Yamato Masafumi 
Published: January 2024

Abstract
Sodium–glucose cotransporter 2 inhibitors (SGLT2i) exhibit renoprotective effect in patients with chronic kidney disease (CKD) and do not increase serum K levels in the long term. However, it is unknown whether SGLT2i increase serum K levels in patients with advanced CKD in the short term. This study aimed to investigate the impact of SGLT2i on changes in serum K levels in patients with advanced CKD.
Data of 127 Japanese patients with CKD who were newly administered 10 mg dapagliflozin in our department between August 2021 and August 2022 were analyzed. Changes in serum K and fractional excretion of K (FEK) were analyzed using multiple regression analysis.
Of 127 patients, 41 were excluded.
The median age was 67 years, and 70.9% were male. Overall, 24 (27.9%) patients had diabetes mellitus. The median estimated glomerular filtration rate (eGFR), serum K levels, and FEK were 35.4 mL/min/1.73 m2, 4.2 mEq/L, and 11.8%, respectively, at the time of dapagliflozin administration. Although eGFR declined to 33.2 mL/min/1.73m2 from 35.4 mL/min/1.73m2 after dapagliflozin administration (p<0.001), serum K and FEK levels increase to 4.3 mEq/L and 14.7% after dapagliflozin administration and it was not statistically significant.
Dapagliflozin did not increase serum K levels in patients with advanced CKD.
Comparison of standard endovascular repair and chimney graft for juxtarenal abdominal aortic aneurysm
Authors: Wang Mingshan , Cai Huoying , Liu Zhen , Huang Lin , Liu Ruiming , Wang Siwen , Qin Yuansen , Cui Jin , Chang Guangqi , Yao Chen , Wang Shenming , Wang Jinsong , Zhou Yu , Hu Zuojun 
Published: January 2024

Abstract

Objective
This study compared the efficacy of standard grafting (S-EVAR) and chimney grafting (Ch-EVAR) for treating juxtarenal abdominal aortic aneurysms(JAAA).
Methods
Data of patients with JAAA, who underwent S-EVAR and Ch-EVAR from January 2015 to December 2021 were collected. Follow-up was performed by CTA and ultrasonography of the aorta were performed before discharge, at 6 and 12 months postoperatively, and annually thereafter. Main outcome measures: AAA-related mortality, type Ia endoleak and reoperation
Results
A total of 62 patients underwent S-EVAR and 23 underwent Ch-EVAR. The proportion of men who underwent S-EVAR (91.9%, 57/62) was higher than the proportion who underwent Ch-EVAR (69.6%, 16/23) (p = 0.023). The postoperative incidence rate of type Ia endoleak was lower in S-EVAR (9.7% vs 13%, p = 0.698). Times for. hospitalization, ICU monitoring, operation, and anesthesia, and perioperative bleeding were less in S-EVAR (12 vs 17 days, 0 vs 1 day, 122.5 vs 220 min, 177.5 vs 300 min, 50 vs 100 mL, p < 0.05). In S-EVAR, a suprarenal aortic angle was associated with type Ia endoleak (p = 0.016). Median follow-up duration was 48 months, (range, 0–94 months) in the S-EVAR group and 42 months (range, 0–90 months) in the Ch-EVAR group. 1-year survival rate were (91.9% vs 91.3%), 3-year survival rate (81.7% vs 78.7%), 5-year survival rate (62.2% vs 45.8%) were not statistically different. No significant differences were found in postoperative complications. The long-term patency rate of chimney stent was 100%.
Conclusions
The off-label use of S-EVAR for JAAA, with a straight and 8–10 mm aortic neck length, can be considered safe and effective. Ch-EVAR is more suitable for JAAA with excessive twisting of the neck (suprarenal aortic angle < 114°). In this study, long-term data of both technologies showed satisfactory results in preventing aneurysm rupture and the related mortality.
Effect Of Dexmedetomidine On Controlled Hypotension In Hypertensive Patients Undergoing Endoscopic Sinus Surgery
Authors: Ye Li-Sha , Wang YiXuan , Wang BenFu , Jin YueXi , Ye WenLian , Jiang Tian-Fang 
Published: January 2024

Abstract
Nasal endoscopic surgery is a high-resolution, fine-grained procedure. With the development of nasal endoscopic surgery, the demand for a clear surgical field of vision is gradually increasing. Controlled hypotension technology can effectively reduce intraoperative bleeding and provide a clear visual field for surgery. In hypertensive patients, we use dexmedetomidine as an adjuvant on the basis of traditional nitroglycerin controlled hypotension. The experimental results show that the use of dexmedetomidine can help control blood pressure faster to the target blood pressure, while also exhibiting more stable performance during resuscitation and extubation. Although in terms of heart rate
The effect of motor interventions on gross motor skills in children with autism: a systematic review and META analysis
Authors: CAO YUANG , FAN LIXIA , MAO XIAOJIN 
Published: January 2024

Abstract
OBJECTIVE
To systematically and quantitatively evaluate the effects of different forms of interventions on the development of gross motor skills in children with autism and to provide a reference for further enhancing the development of gross skills in children with autism.
METHODS
Randomised controlled trials (RCTs) on gross motor skill interventions for children with autism were collected according to the criteria developed by searching in China Knowledge Network (CNKI), Wanfang Digital Resources, Wipu database, and web of science database. The Chinese and English search terms included: (autism OR autism spectrum disorder) AND (motor skill OR fundamental motor skill OR fundamental movement skill) AND (pupil OR child). The retrieved literature was screened, data extracted, and the quality of the included literature was evaluated using Cochrane. Meta-analysis and sensitivity analysis, regression analysis, and publication bias were performed using Review Manager 5.4 and Stata 15.1 software.
Result
Meta-analysis results showed that targeted motor interventions significantly improved the development of gross motor skills in children with autism and were effective in improving the total TGMD scores of children with autism (SMD = 13.61, 95% CI [8.77,18.46]). There was a significant increase in displacement skills (SMD = 7.07, 95% CI [5.20,8.94]) and object control skills (SMD = 6.55, 95% CI [4.98,8.12]). In terms of displacement skills, a certain duration of motor intervention had a good effect on children with autism for fast running, side sliding, single-leg jumping, and straddle jumping, but not for front sliding and standing long jump. In terms of object control skills: the motor intervention significantly improved children with autism's ability to throw the ball underhand, kick the ball, and hit the stationary ball, but not overhand throwing and slapping the ball in place.
Conclusion
Targeted motor interventions have an important role in promoting gross skills in children with autism spectrum disorders. Further research should be conducted to validate this with larger sample sizes and high-quality RCTs.
A case of newly diagnosed acute myeloid leukemia with multiple myeloma: challenges in diagnosis and treatment
Authors: Li Liang , Liu Haiyun , Liu Tingting 
Published: January 2024

Abstract
Background: It is a rare coincidence that acute myeloid leukemia and multiple myeloma are diagnosed simultaneously in patients without a history of malignant diseases and special treatment. The pathogenesis, differential diagnosis, and treatment of these patients are still unclear, and currently they are mainly evaluated based on the specific situation of MICM classification.
Case report: An 81 year old male with a 2-year history of hypertension was admitted to the hospital for treatment due to recurrent chest tightness and pain for 3 years, which worsened for 1 day. During physical examination, there is obvious chest tightness when lying flat, with general limited mobility, anemic appearance, visible bleeding points on the skin and mucosa, no fever, no liver, spleen, or lymph node enlargement. Bone marrow morphology examination showed active bone marrow hyperplasia, with 28% of primitive cells and weakly positive peroxidase staining; The proportion of plasma cells significantly increased, accounting for 15%; The mature red blood cells are arranged in a prominent shape. At the same time, flow cytometry and bone marrow biopsy revealed two different abnormal cell populations, with 42% being primitive myeloid cells and 10% being abnormally proliferating plasma cells. Serum M protein was detected by serum electrophoresis and immunofixation electrophoresis, and specific reaction precipitation bands were observed with anti IgG and anti LAM. The diagnosis was acute myeloid leukemia with multiple myeloma, and there was no history of malignant disease or special treatment.
Treatment and outcome: The patient initially received BCL inhibitor Venetoclax and demethylated drug Azarcytidine for the treatment of acute myeloid leukemia. Subsequently, due to severe cardiac insufficiency caused by coronary atherosclerotic heart disease, the patient could not tolerate the follow-up treatment, and was automatically discharged to the local hospital for life support treatment.
Discussion: In the clinical process of diagnosing and treating hematological diseases, it is rare for these two different types of clonal malignant hematological diseases to occur simultaneously. Patient based prospective studies and case series are needed to guide diagnosis and treatment strategies.
Depressive symptoms prevalence and its associated factors among cross border migrants in Thailand, 2023: a cross-sectional mixed-method study
Authors: Sikhiwat Naruemon , Rajsiri Kullatida , Nunes Jordanna , Uansri Sonvanee , Panapong Nitjanan , Kunpeuk Watinee , Adhibai Rujira , Wongsuwanphon Saruttaya , Suphanchaimat Rapeepong 
Published: January 2024

Abstract

Background: Depression constitutes a substantial portion of global mental health concerns. Among migrant populations, access to mental healthcare is often hindered by various barriers, potentially leading to undiagnosed depressive symptoms. Thailand has hosted a large number of cross-border migrants from its neighboring countries, especially, Cambodia, Laos PDR and Myanmar (CLM), for years. However, little is known about the prevalence of depressive symptoms and its associated factors amongst migrants in Thailand, and this comes the objective of this study.
Methods: We conducted a cross-sectional mixed-method study to assess the prevalence of depressive symptoms and identify its associated factors. Quantitative data were collected through a paper-based questionnaire which comprised demographic characteristics and depressive symptoms screening questions by the Department of Mental Health, the Thai Ministry of Public Health. Multiple logistic regression analysis was used to determine the related factors of depressive symptoms. Qualitative data were gathered by in-depth interviews with civic group representatives and migrants. Content analysis with inductive coding was applied.
Results: A total of 431 participants were included in the analysis, with the majority being female (73.3%) and from Myanmar (97.9%). The prevalence of depressive symptoms was 11.8%, categorized as mild (9.7%), moderate (1.6%), and severe (0.5%) respectively. Factors associated with reduced likelihood of depressive symptoms included having public insurance, completing at least high school education, and being employed, while alcohol consumption increased the odds of depressive symptoms. Qualitative analysis highlighted the protective role of public insurance against depressive symptoms. Besides, from the interviews, some migrants consumed alcohol as a coping mechanism towards depressive symptoms.
Conclusion: This study reveals a noteworthy prevalence of depressive symptoms among cross-border migrants in Thailand. Significant factors included being insured by public insurance scheme, obtaining favorable education background and being employed. A better understanding of how these factors contribute to depressive symptoms is vital in designing comprehensive mental health policies to address the mental well-being of migrants. Further studies that reach out to all types of migrants and expand the scope of mental health beyond depressive symptoms are recommended.
Comparison of Different Screening Methods for Selection of Ascochyta Blight Disease on Chickpea (Cicer arietinum L.) Genotypes
Authors: Aydoğan Abdulkadir 
Published: January 2024

Abstract
Chickpea (Cicer arietinum L.) is the second most important and commonly grown edible food legume crop all over the world. However, chickpea cultivation and production are mainly affected by Ascochyta Blight (AB) disease that results in up to 100% loss in areas having high humidity and warm temperature conditions. Various screening methods are used in the selection of chickpea genotypes for resistance to AB disease. These methods are Natural Field Condition (NFC), Artificial Epidemic Field Condition (AEFC), Marker Assisted Selection (MAS), and Real-Time PCR (RT-PCR). The study was conducted between the 2014 to 2016 growing seasons with 88 chickpea test genotypes. The results of the screening were used to sort the genotypes into the three categories susceptible (S), moderately resistant (MR), and resistant (R). Using MAS screening, 13, 21, and 54 chickpea genotypes were identified as S, MR, and R, respectively. For RT-PCR screening, 39 was S, 31 was MR, and 18 genotypes were R. NFC screening revealed 7, 17, and 64 genotypes that were S, MR, and R while 74 and 6 genotypes were S and MR, 8 genotypes were R to AB disease in the AEFC method.
Epidemiologic relationship between alcohol flushing and smoking in the Korean population: the Korea National Health and Nutrition Examination Survey
Authors: Yook Hwa Jung , Lee Gyu-Na , Lee Ji Hyun , Han Kyungdo , Park Young Min 
Published: January 2024

Abstract
Although facial flushing after drinking alcohol (alcohol flushing response) is common in Asian populations, the epidemiological features in a large sample have been investigated in only a few studies. This study assessed the epidemiologic characteristics and risk factors of alcohol flushing in a Korean population. This study was based on data collected during the 2019 Korea National Health and Nutrition Examination Survey (KNHANES). A total of 5,572 Korean adults was included in the general population group, and the alcohol flushing group consisted of 2,257 participants. Smoking and physical activity were evaluated as possible risk factors for alcohol flushing. The overall prevalence of alcohol flushing was estimated at 40.56% of the general population (43.74% in males and 37.4% in females), and the prevalence was highest at 60–69 years of age and lowest in individuals older than 80 years. Occasional, frequent, and persistent alcohol flushing was reported by 11.9%, 3.7%. and 15.0% of current flushers, among whom persistent flushers consumed the least amount of alcohol. The risk of alcohol flushing increased with current smoking status (adjusted OR 1.525, 95% CI 1.2–1.938), and smoking history of 20–29 pack-years (PYs) showed the highest association (adjusted OR 1.725, 95% CI 1.266–2.349) with alcohol flushing after adjustment for confounders. In contrast, significant association was not found between physical activity and alcohol flushing. The results demonstrated that current smoking could increase the risk of alcohol flushing, and that current smokers with a history of smoking > 20 PYs had a higher risk of alcohol flushing than non-smokers or ex-smokers.
Basal cell carcinoma superficial type is a basal cell carcinoma in situ
Authors: Kaur Harsimran , Bentley Karen L. de Mesy , Rahman Minhaj , R.Cohen Philip , Smoller Bruce R. 
Published: January 2024

Abstract
Background:
Basal cell carcinoma (BCC) is the most common skin cancer with rising incidence. Skin cancers may present either as non-invasive or invasive malignancy. The terminology of carcinoma in situ is used when the tumor is either just limited to epidermis or not present as single cells or nests in the dermis. However, unlike the usual terminology, superficial BCC instead of BCC in situ is used for BCC that is limited to epidermis.
Purpose:
We aim to compare the histomorphology of superficial BCC to nodular and infiltrative BCCs using electron microscopy to identify the ultrastructural characteristics and validate the previously proposed terminology.
Methods
A total of three cases from three BCC types (superficial BCC, nodular BCC, and infiltrative BCC) diagnosed by dermatopathologists at our institute were selected for review. Paraffin block tissue from these cases was sent for electron microscopy studies.
Results
Electron microscopy demonstrates disruption of basal lamina in both nodular and infiltrative type of BCC, while it remains intact in BCC superficial type after extensive examination.
Conclusion
Our study demonstrates intact basal lamina in the BCC superficial type; therefore, like with other in situ skin cancers there is no invasion of the neoplasm into the dermis. Therefore, the older term superficial BCC should be appropriately replaced with the newer terminology BCC in situ.
Myoclonus improvement after seizures in progressive myoclonic epilepsy type 7: a case report
Authors: Guimarães Thiago Gonçalves , Nóbrega Paulo Ribeiro , Freua Fernando , Lima Pedro Lucas Grangeiro de Sá Barreto , Braga-Neto Pedro , Paiva Anderson Rodrigues Brandão , Kok Fernando 
Published: January 2024

Abstract
Background: Progressive Myoclonic Epilepsy (PME) is a group of rare diseases that are difficult to differentiate from one another based on phenotypical characteristics.
Case Report: We report a case of PME type 7 due to a pathogenic variant in KCNC1 with myoclonus improvement after epileptic seizures.
Discussion: Myoclonus improvement after seizures may be a clue to the diagnosis of Progressive Myoclonic Epilepsy type 7.
Identification of small molecule inhibitors against Lin28/let-7 to suppress tumor progression and its alleviation role in LIN28-dependent glucose metabolism
Authors: Raja Rachanaa , Sundarraj Rajamanikandan , Kandasamy Ruckmani 
Published: January 2024

Abstract

The reciprocal suppression of an RNA binding protein LIN28 (human abnormal cell lineage 28) and miRNA Let-7 (Lethal 7) is considered to have a prime role in hepatocellular carcinoma (HCC). Though targeting this inhibition interaction is effective for therapeutics, it causes other unfavorable effects on glucose metabolism and increased insulin resistance. Hence, this study aims to identify small molecules targeting Lin28/let-7 interaction along with additional potency to improve insulin sensitivity. Of 22,14,996 small molecules screened by high throughput virtual screening, 6 molecules, namely 41354, 1558, 12437, 23837, 15710, and 8319 were able to block the LIN28 interaction with let-7 and increase the insulin sensitivity via interacting with PPARγ (peroxisome proliferator-activated receptors γ). MM-GBSA (Molecular Mechanics-Generalized Born Surface Area) analysis is used to re-score the binding affinity of docked complexes. Upon further analysis, it is also seen that these molecules have superior ADME (Absorption, Distribution, Metabolism and Excretion) properties and form stable complexes with the targets for a significant period in a biologically simulated environment (Molecular Dynamics simulation) for 100 ns. From our results, we hypothesize that these identified 6 small molecules can be potential candidates for HCC treatment and the glucose metabolic disorder caused by the HCC treatment.
HDAC Inhibitor Regulates the Tumor Immune Microenvironment via Pyroptosis in Triple Negative Breast Cancer
Authors: YANG XUE , Cui Xiaoqing , Wang Ge , Zhou Mengying , Wu Yonglin , Du Yaying , Li Xingrui , Xu Tao 
Published: January 2024

Abstract

Objective
Pyroptosis, an inflammatory form of cell death, promotes the release of immunogenic substances and stimulates immune cell recruitment, a process which could turn cold tumours into hot ones. Thus, instigating pyroptosis in triple-negative breast cancer (TNBC) serves as a viable method for restoring anti-tumor immunity.
Methods
We analyzed the effects of Histone Deacetylase Inhibitors (HDACi) on TNBC cells using the CCK8 and colony formation assay. Apoptosis and lactate dehydrogenase (LDH) release assays were utilized to determine the form of cell death. The pyroptotic executor was validated by qRT-PCR and Western Blot. Transcriptome was analyzed to investigate pyroptosis-inducing mechanisms. A subcutaneously transplanted tumor model was generated in BALB/c mice to evaluate infiltration of immune cells.
Results
HDACi significantly diminished cell proliferation, and pyroptotic “balloon”-like cells became apparent. HDACi led to an intra and extracellular material exchange, signified by the release of LDH and the uptake of propidium iodide. Amongst the gasdermin family, TNBC cells expressed maximum quantities of GSDME, and expression of GSDMA, GSDMB and GSDME were augmented post HDACi treatment. Pyroptosis was instigated via the activation of the caspase 3-GSDME pathway with the potential mechanisms being cell cycle arrest and altered intracellular REDOX balance due to aberrant glutathione metabolism. In vivo experiments demonstrated that HDACi can activate pyroptosis, limit tumor growth, and escalate CD8 + lymphocyte and CD11b + cell infiltration along with an increased presence of granzyme B in tumors.
Conclusion
HDACi can instigate pyroptosis in TNBC, promoting infiltration of immune cells and consequently intensifying the efficacy of anticancer immunity.
GIS Based Artificial Neural Network(Ann) Method for Flood Susceptibility Mapping Case of Djelfa City (Algeria)
Authors: Ameur Harfouche , lynda Djerbal 
Published: January 2024

Abstract

Djelfa city situed in the center of Algeria,is particuulary prone to the risk of flooding due to its topography and location,especially considering the presence of unpredictable and forceful watercourses like Oued mellah and Oued boutrifis flowing through the urban area. Various methods exist for predicting and mapping flood susceptibilityand the latest approaches involve deep learning machine and artificial neural networks,which were employed in the current study.
Four geoenvironmentalflood conditioning factors were considered including elevation, slope,urban density and distance to streams. Recent artificial neural network(ANN)model has been used to obtain an optimal output with minimized cross entropy error and better assess flood susceptibility in Djelfa City.The weights for each factor were determined using the backpropagation training method.Subsequently,flood susceptibility indices were calculated using the trained backpropagation weights and susceptibility maps were created based on geographic information system (GIS) data.The results of the flood susceptibility maps were then compared to flood location data to validate the model.The good convergence of the resultsclearly demonstrates that artificial neural network is an effective tool to analyzing flood susceptibility.