bluuebunny/crossref_metadata_2025_split huggingface dataset:
Anticancer Potential of Novel Cinnamoyl Derivatives against U87MG and SHSY-5Y
Cell Lines
Authors: Gouleni Niki , Di Rienzo Annalisa , Oner Sena , Karagöz Ceren , Arslan Mehmet Enes , Mardinoglu Adil , Turkez Hasan , Di Stefano Antonio , Vassiliou Stamatia , Cacciatore Ivana 
Published: November 2023

Background:
Glioblastoma multiforme (GBM) is probably the most malignant and aggressive brain
tumor belonging to the class of astrocytomas. The considerable aggressiveness and high malignancy of GBM
make it a tumor that is difficult to treat. Here, we report the synthesis and biological evaluation of eighteen novel
cinnamoyl derivatives (3a-i and 4a-i) to obtain more effective antitumor agents against GBM.

Methods:
The chemical structures of novel cinnamoyl derivatives (3a-i and 4a-i) were confirmed by NMR and
MS analyses. The physicochemical properties and evaluation of the ADME profile of 3a-i and 4a-i were performed
by the preADMETlab2.0 web program. Cinnamoyl derivatives 3a-i and 4a-i were tested in vitro for their
cytotoxicity against the human healthy fibroblast (HDFa) cells using an MTT cell viability assay. Derivatives
with no toxicity on HDFa cells were tested both on human glioblastoma (U87MG) and neuroblastoma (SHSY-
5Y) cells, chosen as an experimental model of brain tumors. Cell death mechanisms were analyzed by performing
flow cytometry analyses.

Results:
Cinnamoyl derivatives 3a-i and 4a-i showed good physicochemical and ADME properties suggesting
that these compounds could be developed as oral drugs endowed with a high capability to cross the blood-brain
barrier. Compounds (E)-1-methoxy-4-(2-(phenylsulfonyl)vinyl)benzene (2c) and (E)-N-benzyl-N-(2-
(cyclohexylamino)-2-oxoethyl)-3-(3,4,5-trimethoxyphenyl)acrylamide (3e) did not show cytotoxicity on healthy
human fibroblast cells up to 100 μg/mL. The most anticarcinogenic molecule, compound 3e, emerged as the most
potent anticancer candidate in this study. Flow cytometry results showed that compound 3e (25 μg/mL) application
resulted in nearly 86% and 84% cytotoxicity in the U87MG and the SHSY-5Y cell lines, respectively. Compound
2c (25 μg/mL) resulted in 81% and 82% cytotoxicity in the U87MG and the SHSY-5Y cell lines, respectively.

Conclusion:
Cinnamoyl derivative 3e inhibits the proliferation of cultured U87MG and SHSY-5Y cells by inducing
apoptosis. Further detailed research will be conducted to confirm these data in in vivo experimental animal
models.
Exploring the Synergistic Effect of Sildenafil and Green Tea Polyphenols on Breast
Cancer Stem Cell-like Cells and their Parental Cells: A Potential Novel Therapeutic
Approach
Authors: Salari Sharif Marzie , Mohseni Habibeh Sadat , Khanavi Mahnaz , Ghadami Shima , Jafarzadeh Emad , Tavajohi Shohreh , Aliebrahimi Shima , Ostad Seyed  Nasser 
Published: November 2023

Background::
Many cancer studies have intensely focused on the role of diet, among other factors
involved in cancer establishment. The positive effect of green tea polyphenols (GTP) on controlling breast cancer
cells has been reported in several studies. Cancer stem cell-like cells (CSC-LCs) possessing self-renewal, metastatic,
and drug-resistant capacities are considered prominent therapeutic targets. In many tumors, inducible nitric
oxide synthase (iNOS) expression levels are high; however, they have a dual effect on breast cancer pathogenesis.

Objective::
This study aimed to investigate the cytotoxicity of the iNOS agonist (Sildenafil) and antagonist (LNAME),
both alone and in combination with GTP, on MDA-MB-231, CD44+/CD24- CSC-LCs, and their parental
cells (MCF-7).

Methods::
The cell viability assay has been studied using the MTT assay. To analyze drug-drug combinations,
CompuSyn and Combenefit software were used. The cytotoxicity mechanism was determined using flow
cytometric analysis.

Results::
L-NAME and GTP showed a synergistic effect on MDA-MB-231 and CSC-LCs. Such an effect was not
observed on MCF-7. Sildenafil and GTP, on the other hand, showed synergistic cytotoxicity in all the cells
mentioned above. Flow cytometric tests resulted in more than 70% apoptosis in MDA-MB-231 and MCF-7. Also,
sub-G1 arrest among MCF-7 cells and a considerable decrease in ROS production by MDA-MB-231 cells
following treatment with Sildenafil and GTP were observed.

Conclusion::
Sildenafil, in combination with flavonoids, may be considered a novel strategy for cancer treatment.
Data Breach Severity and Debt Market Responses
Authors: Evans Corey A. , Beyer Brooke , Mason Terry W. , West Ashley N. 
Published: November 2023

ABSTRACT
Prior literature has become increasingly inconsistent as to the impact of data breaches, in part because researchers have not settled on an appropriate identifier for breach severity. The goal of our study is to develop a breach severity measure and validate the new measure by investigating the relation between breach severity and debt market responses. Using the new measure, we find severe data breaches are positively associated with the cost of debt, the size of new debt facilities, the total number of new debt facilities issued, and the average number of lenders included in the new facilities. We also provide evidence that financially constrained firms are more likely to be adversely affected by a severe data breach. Collectively, the results suggest our new breach severity measure is an effective measure of data breach severity.
Data Availability: Data are available from the public sources cited in the text.
JEL Classifications: G32; M41.
Clinical Performance of Minimally Invasive Monolithic Ultratranslucent Zirconia Veneers: A Case Series up to Five Years of Follow-up
Authors: Silva NR , Araújo GM de , Moura DMD , Araújo LNM de , Gurgel BC de Vasconcelos , Melo RM , Bottino MA , Özcan M , Zhang Y , Souza ROA 
Published: November 2023

SUMMARY
There is a lack of reports in the literature on the long-term clinical performance of ultratranslucent zirconia, especially considering its use in manufacturing monolithic veneers. The purpose of this case series is to describe the aesthetic treatment steps of three patients with minimally invasive ultratranslucent zirconia veneers and to report the clinical findings up to five years. Three patients (woman: 2, man: 1; mean age: 30 years) unsatisfied with their dental aesthetics sought dental treatment. The treatment plan involved cementing ultratranslucent zirconia veneers. Air-abrasion was performed on the internal surface of zirconia with alumina particles coated by silica (silicatization), followed by silane and adhesive applications for the adhesive cementation. All veneers were adhesively cemented to enamel with resin cement (Variolink Esthetic, Ivoclar). The patients were clinically evaluated annually considering the Ryge modified/ California Dental Association criteria. After a mean follow-up of 4.33 years (4-5 years), a survival rate of 100% was detected for the 28 minimally invasive ultratranslucent zirconia veneers cemented in the 3 patients. There were no absolute failures such as debonding, veneer fracture, or secondary caries. Superficial marginal discoloration was observed in one element (maxillary left lateral incisor) of one patient. Ultratranslucent zirconia is a viable option for manufacturing veneers due to its excellent clinical performance and longevity. However, further long-term clinical studies are essential to consolidate this material as an option for esthetic restorations.
Improving Bond Strength of Translucent Zirconia Through Surface Treatment With SiO2-ZrO2 Coatings
Authors: Du Q , Cui T , Niu G , Qui J , Yang B 
Published: November 2023

SUMMARY

Background
Translucent monolithic zirconia ceramics have been applied in dental clinics due to their esthetic translucent formulations and mechanical properties. Considering inherent ceramic brittleness, adhesive bonding with resin composite increases the fracture resistance of ceramic restorations. However, zirconia is a chemically stable material that is difficult to adhesively bond with resin.

Objectives
To investigate the influences of SiO2-ZrO2 coatings on adhesive bonding of zirconia and the surface characterization of those coatings.

Methods and Materials
Translucent zirconia discs were classified into groups based on surface treatments: CT (control), SB (sandblasting), C21(SiO2:ZrO2=2:1), C11(SiO2:ZrO2=1:1), and C12 (SiO2:ZrO2=1:2) (n=10). Surface characterization of coatings on zirconia were analyzed by scanning electron microscopy (SEM), energy-dispersive X-ray spectroscopy (EDX), surface roughness assessment (Ra), X-ray diffraction (XRD), water contact angle (WCA), translucency parameter (TP), and shear bond strength (SBS). Two-way ANOVA for shear bond strength results and ANOVA for Ra and WCA were performed.

Results
SEM images revealed SiO2 islands on zirconia disks coated with SiO2-ZrO2. Surface roughness of C12, C11, and C21 groups was significantly larger than those of groups SB and CT (p&lt;0.05). XRD results showed that phase transformation of zirconia disks was detected only in the SB group. In addition, SiO2-ZrO2 coatings reduced WCA. The translucency decreased only in group C21. Group C11 showed the highest shear bond strength under both aging conditions.

Conclusion
SiO2-ZrO2 coating is a promising method to enhance the adhesive resin bonding of translucent zirconia without causing phase transformation of translucent zirconia.
Green Building Assessment and Recommendations for Optimization Case Study of the Rectorate Building the University of Lampung
Authors: Kustiani Ika , Helmi Masdar , Aini Nur Syahidah 
Published: November 2023

The Green Building Concept is a concept that offers a method of managing buildings with less energy and resources utilization to minimize the environmental impact. Since its implementation to be mandator, it is time for the University of Lampung to start implementing this concept. This research was aimed at assessing the Rectorate Building rating based on the national standard on Green Building Certification (Greenship-GBCI). There were several steps in conducting this research. Firstly, an opinion survey was conducted to measure the level of satisfaction of the building’s users. Secondly, a series of measurements related to lighting, temperature, humidity, noise, and air quality were carried out. Furthermore, an interview survey related to the operation and maintenance of the building were conducted. Finally, all of these data were entered in the Green Building rating tool for existing buildings. The results showed that the Rectorate Building score was 23 out of 117. This score is way below the score for a bronze rating of 35. Therefore, corrective action must be taken in order the building operation management to meet the Greenship-GBCI standard. Assessment also needs to be done on buildings througout the university for a reference in developing the University of Lampung Eco-campus program.
Evaluation of the Technological Properties of Artificial Agglomerated Stones in Epoxy Resin and Castor Oil-Based Vegetable Polyurethane Matrix
Authors: Castilho Evanizis Dias Frizzera , Sant'Ana Maria Angelica Kramer , Teixeira Dullye Noleto Lima , Silva Maria Eduarda Delabeneta , Gadioli Mônica Castoldi Borlini 
Published: November 2023

Objective: The aim of this study was to produce and evaluate the technological properties of artificial agglomerated stone slabs produced using the waste from the stone commercially known as "Preto São Gabriel," using epoxy resin and castor oil-based polyurethane.

Theoretical framework: Ornamental stones are widely used in the construction sector and are of great economic importance to the country. During the production stages, a significant amount of waste is generated. The production process generates a substantial amount of waste from the extraction and processing processes that have no economic value, accounting for approximately 40 to 60% of the production during mining, and during the cutting stage, about 30 to 35% is generated.

Method: To manufacture the artificial stone slabs, the waste was crushed in a jaw crusher and ceramic plate mill and screened into three particle size ranges. The slabs were produced using the vacuum vibro-compression method. Technological characterization tests were conducted, including bulk density, apparent porosity, water absorption, and three-point strength tests.

Results and conclusions: It is concluded that slabs produced with both resins can be applied in locations requiring good flexural strength. For use in areas with water presence, those produced with epoxy resin are recommended, as they exhibited lower porosity and water absorption.

Research implications: Utilizing waste from ornamental stones, which amounts to millions of tons and is disposed of in landfills or storage facilities, to manufacture agglomerated stones represents a significant contribution to environmental impact reduction, aligning with the principles of ESG (Environmental, Social, and Corporate Governance).

Originality/value: The evaluation of the technological properties of artificial agglomerated stones produced from ornamental stone waste is of fundamental importance for the correct and safe application of these sustainable materials in civil construction.
Diagnosis and Obstacles Related to the Production Chain of Cachaça in the Context of Geographical Indications
Authors: Saldanha Cleiton Braga , Silva Daliane Teixeira , Martins Luís Oscar Silva , Silva Marcelo Santana 
Published: November 2023

Objective: To analyze regulatory and public policy, economic, agronomic, infrastructure, and technological barriers in the context of Geographical Indications.

Method: This study was carried out from the perspective of exploratory research since it is a conceptual approach, which investigates the main characteristics of the studied phenomenon. Considering the way in which the data were obtained, it consists of a bibliographical study of a qualitative nature, which has the cachaça productive chain as its central element.

Results and conclusion: It is observed that the foundation of the GI is based on the relationship between natural resources, the organization of social and economic processes, and cultural and power relations. The obstacles highlighted from the point of view of specialists directly affect the development process of the cachaça production chain, but it is a historically important activity for Brazil.

Research implications: They range from direct support to the cachaça industry and the formulation of public policies to the advancement of academic knowledge and the strengthening of regional culture and economy. It contributes to multiple aspects of society, highlighting the relevance of Geographical Indications.

Originality/value: The identification of critical obstacles in the cachaça production chain, deepening the understanding of the complex relationship between natural resources, culture, and social and economic processes in the formation of Geographical Indications (GIs) in Brazil fills an important gap in the context of the growing recognition of GIs in Brazil.
The life path and scientific works of Academician V.K. Kulagina
Authors: Цыган В.Н. , Мамаева С.А. 
Published: November 2023

Статья посвящена анализу массива научных публикаций выдающегося патофизиолога академика Виктора Константиновича Кулагина. Цель сообщения – раскрыть и подчеркнуть вклад В.К. Кулагина в разработку учения о травме и шоке. Анализ показал, что основными аспектами экспериментальных исследований ученого были нейрогуморальные механизмы развития травматического шока, различия травматического шока и шока при кровопотере, роль нарушений функций эндокринной системы (гипофиз, кора надпочечников) и значение изменений ряда ферментных систем в патогенезе шока. Кулагин разработал методы ранней профилактики и принципы лечения шока и кровопотери с использованием крови, кровезаменителей, адренокортикотропного гормона, кортикостероидов и некоторых ферментов. Результаты проведенных им исследований позволили создать целостную патогенетически обоснованную картину шока. Кулагин вплотную подошел к решению проблемы ранней профилактики шока, стоял у истоков концепции травматической болезни.
The purpose of the article is based on the analysis of the array of scientific publications of the outstanding pathophysiologist, academician V.K. Kulagina to reveal his contribution to the development of the doctrine of trauma and shock. The analysis showed that the main aspects of the scientist’s experimental studies were the neurohumoral mechanisms of the development of traumatic shock, the differences between traumatic shock and blood loss, the role of dysfunctions of the endocrine system (pituitary gland, adrenal cortex), the significance of changes in a number of enzymatic systems in the pathogenesis of shock. Kulagin developed methods for early prevention and principles for the treatment of shock and blood loss using blood, blood substitutes, adrenocorticotropic hormone, corticosteroids, and certain enzymes. The results of his studies made it possible to create a holistic pathological picture of shock. Kulagin came close to solving the problem of early prevention of shock, stood at the origins of the concept of traumatic disease.
Kesulitan Belajar Siswa Selama Pembelajaran Daring Dimasa Pandemi COVID-19
Authors: Putri Rukiana Novianti , Nur Syaifullah 
Published: November 2023

Abstrak : Pembelajaran daring menjadi alternatif dalam pembelajaran di tengah pandemi COVID-19. Hal ini menjadi tantangan baru baik bagi pemerintah, guru maupun siswa agar proses belajar mengajar dapat terus berlangsung. Penelitian ini bertujuan mengetahui karakteristik perilaku kesulitan belajar siswa selama pembelajaran daring dimasa pandemi Covid-19. Penelitian menggunakan pendekatan kuantitatif dengan deskriptif analitik yang jumlah sampel 150 responden. Hasil penelitian menunjukkan bahwa kesulitan belajar siswa selama pembelajaran daring pada kategori sedang. Adapun karakteristik kesulitan belajar yang dialami oleh siswa diantaranya: 1) Perhatian siswa mudah teralihkan oleh hal disekitar sehingga kurang fokus saat belajar; 2) Materi pelajaran sulit dipahami walau sudah berusaha mempelajarinya; 3) Kurang mampu berkonsentrasi saat belajar; 4) Membutuhkan tambahan waktu untuk menyelesaikan tugas; 5) Mudah mengantuk/bosan saat belajar sendiri.Kata kunci: kesulitan belajar, pembelajaran daring, Covid-19
PENERAPAN TEKNIK ACTING OPPOSITE UNTUK MENINGKATKAN EMOSI POSITIF SISWA DI SMP NEGERI 23 MAKASSAR
Authors: D Nurhidayatullah , Salmiati Salmiati 
Published: November 2023

Penelitian ini menelaah Penerapan Teknik Acting Opposite untuk meningkatkan Emosi Positif Siswa di SMPN 23 Makassar. Masalah dalam penelitian ini adalah: 1.Bagaimana tingkat emosi positif siswa di SMPN 23 Makassar? 2. Bagaimana gambaran pelaksanaan acting opposite di SMPN 23 Makassar?. Tujuan penelitian ini adalah untuk mengetahui : 1. Gambaran emosi positif siswa di SMPN 23 Makassar. 2. Gambaran pelaksanaan acting opposite di SMPN 23 Makassar. 3. Perbedaan rata-rata kelompok yang diberikan perlakuan berupa teknik acting opposite dengan kelompok yang tidak diberikan perlakuan dalam meningkatkan emosi positif siswa di SMPN 23 Makassar. Jenis penelitian ini adalah penelitian kuantitatif dengan pendekatan quasi experimental design dengan desain nonequivalent control group design. Populasi penelitian ini adalah siswa kelas VIII SMPN 4 Bulukumba. Sampel penelitian sebanyak 20 siswa yang terbagi menjadi 10 pada kelompok kontrol dan 10 pada kelompok eksperimen. Pengumpulan data dengan menggunakan instrumen angket dan observasi. Analisis data menggunakan analisis statistik deskriptif dan analisis statistik inferensial dengan uji t. Hasil penelitian menunjukkan bahwa: 1. Tingkat emosi positif siswa di SMPN 23 Makassar berada pada kategori rendah. 2) Pelaksanaan teknik acting opposite yang dilakukan melalui 3 tahapan di SMPN 23 Makassar berada pada kategori tinggi. Artinya, siswa berpartisipasi aktif dan antusia selama kegiatan pemberian treatment.. Artinya, teknik acting opposite dapat meningkatkan emosi positif siswa di SMPN 23 Makassar
PENGARUH PELECEHAN SEKSUAL TERHADAPMENTAL SISWA DI DUTA PELAJAR GOWA
Authors: Iskandar Wahyuni , Azizah Nur , Satriani Siti 
Published: November 2023

Pelecehan seksual adalah perilaku pendekatan yang terkait dengan seks atau Tindakan seksual yang tidak diinginkan termasuk permintaan untuk melakukan seks menyebabkan pelanggaran dan ketidaknyamanan dan termasuk bentuk penghinaan atau memandang rendah sesorang karena hal-hal yang berkenaan dengan seseorang. Kesehatan mental dapat mengakibatkan sesorang mengalami gangguan suasana hati, kemampuan berpikir serta kendali emosi yang pada akhirnya mengarah pada perilaku buruk. Penyakit mental dapat menyebabkan masalah kehidupan sehari-hari, tidak hanya dapat merusak interaksi atau hubungan dengan orang lain, namun juga dapat menurunkan prestasi disekolah dan produktivitas kerja. Adapun yang menjadi rumusan masalah adalah bagaimana pengaruh pelecehan seksual terhadap duta remaja di lembaga duta pelajar. Tujuan dan manfaat untuk mengetahui pengaruh pelecehan seksual terhadap mental remaja di lembaga duta pelajar. Jenis penelitian yang digunakan adalah penelitian kualitatif dengan menggunakan pendekatan secara inquiri desktiktif sebagai strategi penelitian. Teknik pengumpulan data menggunakan wawancara, rekaman dan dokumentasi. Analisis data yang digunakan yaitu pengumpulan data, reduksi data, penyajian data dan penarikan kesimpulan. Adapun hasil penelitian berdasarkan hasil wawancara terhadap narasumber yaitu di sekolah masih minim pembelajaran seksual, pengetahuan terhadap pelecehan seksual dominan siswa sudah mengetahui mengenai hal tersebut baik itu pelecehan seksual secara verbal maupun secara langsung. Sehingga dengan adanya perilaku pelecehan seksual siswa sudah mampu mengetahui jenis-jenis pelecehan seksual yang dilakukan dan sehingga sudah mampu menghindari pelecehan seksual dan ada beberapa siswa telah mengalami pelecehan seksual sehingga tidak mudah bagi mereka untuk menghilangkan trauma yang dirasakan. Kata Kunci: Duta Pelajar, Mental Remaja, dan Pelecehan Seksual.
TEKNIK SELF TALK UNTUK MENINGKATKAN KEPERCAYAAN DIRI PADA MAHASISWA
Authors: Wulandari Ratna 
Published: November 2023

Abstrak: Tujuan penelitian ini yaitu untuk meningkatkan kepercayaan diri mahasiswa pendidikan ulama tarjih Universitas Muhammadiyah Makassar yang rendah. Penelitian ini menggunakan pendekatan kualitatif jenis studi kasus klinis dengan teknik pengumpulan data melalui wawancara, observasi dan dokumentasi. Data yang diperoleh dianalisis dengan analisis deskriptif kualitatif. Untuk mengatasi permasalahan yang dialami oleh subjek maka diberikanlah teknik self talk. Berdasarkan pemberian bantuan yang telah diberikan kepada subyek, hasil yang diperoleh adalah subyek banyak mengalami perubahan terutama dalam bersosialisasi, seperti sudah baik dalam berkomunikasi, serta menunjukkan tingkah laku yang aktif dan positif. Namun belum mampu mengeksplorasikan kemampuan yang dimilikinya. Kata Kunci: Teknik Self Talk, Kepercayaan Diri, Mahasiswa
MEDIA BIMBINGAN DAN KONSELING DALAM PELAKSANAAN NEED-ASSESSMENT
Authors: Atirah Nur Faisah , Pratama Sandi 
Published: November 2023

Abstact: The research used is qualitative research. This study uses a descriptive analysis research method. The type of data used is secondary data. The methods of collecting data in this study are observation, interviews and documentation and the data analysis process carried out in this study uses three steps, namely: data reduction, data display and conclusion drawing. The sophistication of today's technological media such as the internet, CDs, films, videos from you tube, multimedia percentages and so on will make it easier for counselors to present material to their students. As explained above, learning media that have been developed into guidance and counseling media are not only used in the process of providing guidance and counseling services, but can cover all aspects, starting from program planning, implementing guidance and counseling services and even evaluating the results of guidance. and counseling itself Keywords: Media, BK and Need Assessment