bluuebunny/crossref_metadata_2025_split huggingface dataset:
Botanical insecticides and extracts and their lethal and sublethal effects on Anastrepha obliqua (Macquart) (Diptera: Tephritidae) and Diachasmimorpha longicaudata (Ashmead) (Hymenoptera: Braconidae)
Authors: Costa Daniela Ribeiro da , Leite Suzany Aguiar , de Paula Vanderlúcia Fonseca , Nascimento Jeferson Chagas do , Neto Raymundo José de Sá , Moreira Aldenise Alves , Castellani Maria Aparecida 
Published: October 2023

Abstract

Knowledge of the action of chemical and botanical insecticides on pests and natural enemies is essential for improving integrated management programs of fruit flies. The aimed evaluate the toxic and sublethal effects of botanical insecticides and extracts onAnastrepha obliquaandDiachasmimorpha. longicaudata. Botanical extracts and insecticides were applied to fruit flies or parasitoids, using a methanol extract of leaves ofAspidosperma spruceanum(MLAS), ethanol extract of bark ofMetrodorea maracasana(EBMM), hexane extract of leaves ofConchocarpus mastigophorus(HLCM), ethanol extract of leaves ofC. mastigophorus(ELCM), ethyl acetate extract of leaves ofXylopia sericea(ALXS), and oil of seeds ofAleurites moluccana(OSAM) in single concentration of 70 mg mL− 1, in addition to the insecticides Azamax® (5 mL L− 1) and Natuneem® (10 mL L− 1). Extract EBMM and the two insecticides were used for the lethal effect on theA. obliquaand parasitoid, and extract ELCM only in parasitoid. The extract EBMM was also evaluated onA. obliquaat concentrations of 60, 70, 80, 90, and 100 mg mL− 1. Sublethal effects was carried out with commercial products based on neem and water in adultsA. obliqua. Azamax® and the extracts EBMM, ELCM, and HLCM were toxic toA. obliqua. Natuneem® and the extracts ELCM and EBMM were harmless to adults of theD. longicaudata. Azamax® was considered slightly harmful to the parasitoid. The extract EBMM was harmless to adults or larvae and moderately harmful in the double application. Extract EBMM has the potential for bioprospecting, aiming at tephritid management.
A pilot randomized controlled trial comparing nutritious meal kits and no-prep meals to improve food security and diet quality among food pantry clients
Authors: Hollis-Hansen Kelseanna , Haskins Carolyn , Turcios Jessica , Bowen Michael E. , Leonard Tammy , Lee MinJae , Albin Jaclyn , Chambers Benaye Wadkins , Thompson Cynthia , Hall Taylor , Pruitt Sandi L. 
Published: October 2023

Abstract
Background: Food pantry clients have high rates of food insecurity and greater risk for and prevalence of diet-related diseases. Many clients face time, resource, and physical constraints that limit their ability to prepare healthy meals using foods typically provided by pantries. We compared two novel approaches to alleviate those barriers and encourage healthier eating: meal kits, which bundle ingredients with a recipe on how to prepare a healthy meal, and nutritious no-prep meals, which can be eaten after thawing or microwaving.
Methods: Participants were adult pantry clients from a large food pantry in the Southern sector of Dallas, Texas. We conducted a repeated measures between-subjects study with 70 clients randomized to receive 14-days of meal kits (n=35) or no-prep meals (n=35). Participants completed questionnaires at baseline and two-week follow-up on demographics, hedonic liking of study meals, perceived dietary quality, and food security. Two-way repeated measures analysis of variance was used to examine group and time effects, and group by time interactions. We also describe feasibility and satisfaction outcomes to inform future implementation.
Results: Sixty-six participants completed the study (94%). Participants were predominantly Hispanic or Latino(a) (63%) and African American or Black (31%) women (90%). There was a significant interaction on hedonic liking of study meals (ηp²=0.16, F(1,64)=11.78, p<.001), such that participants that received meal kits had greater improvements in hedonic liking over time than participants in the no-prep group. We observed significant improvements in perceived dietary quality (ηp²=0.36, F(1,64)=36.38, p<.001) and food security (ηp²=0.36, F(1,64)=36.38, p<.001) across both groups over time, but no between group differences or significant interactions indicating one intervention was more effective than the other. Program satisfaction was high across both groups, but higher among the meal kit group (ηp²=0.09, F(1,64)=6.28, p=.015).
Conclusions: Results suggest nutritious meal kits and no-prep meals may be desirable nutrition intervention strategies for pantry clients and have potential to increase food security and perceived dietary quality in the short-term. Our findings are limited by a small sample and short follow-up. Future studies should continue to test both interventions, and include longer follow-up, objective measures of dietary quality, and relevant clinical outcomes.
Trial Registration: This trial was registered on 25/10/2022 on ClinicalTrials.gov, identifier: NCT05593510.
Effects of estazolam, remimazolam and their combination on preoperative anxiety and postoperative pain after gynecological laparoscopic surgery: a double-blind, randomized, controlled trial
Authors: Wang Ying , Wang Yun , Zhang Xin-Dan , Zhang Xue , Chen Xin-Yue , Gao Rui-Jia , Huang Yu , Feng Ji-Ying , Chen Nan 
Published: October 2023

Abstract
Purpose
Preoperative anxiety is closely related to postoperative pain, and high preoperative anxiety can aggravate postoperative pain. We aimed to estimate the effect of estazolam, remimazolam, and their combination on preoperative anxiety and postoperative pain in patients undergoing elective gynecological laparoscopic surgery.
Materials and Methods
We carried out a randomized, double-blind, placebo-controlled experiment between October 2020 and April 2021. A total of 108 patients were split into four groups: (1 mg estazolam or starch was taken orally on the evening before surgery; 0.1 mg/kg remimazolam or normal saline was administered intravenously after entering the operating room) Group E received estazolam and normal saline; Group R received starch and remimazolam; participants in Group ER were given not only estazolam but also remimazolam; participants in Group C were given starch and normal saline. We recorded preoperative anxiety scores (visual analog scale–anxiety [VAS-A]), pain scores (VAS), and cumulative sufentanil consumption after laparoscopic surgery.
Results
The mean anxiety scores were significantly lower in Group E, R, and ER than in Group C before surgery. Compared with Group C, mean pain scores were significantly lower in Group ER at 0.5, 1, 4, 8, 24, 48, and 72 hours after surgery and lower in Group R or E at 4, 8, and 24 hours after surgery. The mean pain scores in Group E (at 8 and 24 postoperative hours) and Group R (at 8 postoperative hours) were both significantly higher than those in Group ER. Moreover, the mean cumulative sufentanil consumption was significantly lower in Group ER at 0.5, 1, 4, 8, 24, 48, and 72 hours after surgery and lower in Group E or R at 0.5 hours after surgery, compared with Group C.
Conclusion
The preoperative application of estazolam, remimazolam, and their combination can relieve preoperative anxiety and postoperative pain for patients undergoing gynecological laparoscopic surgery. Moreover, the preoperative combination can also significantly reduce postoperative sufentanil consumption.
Effects of climatic changes on olive fly, Bactrocera oleae (Rossi) population dynamic and its damages in olive orchards of Qazvin province, Iran
Authors: Keyhanian Ali Akbar , Mojdehi Mohammad Reza Abbasi , Rafiei Bahareh 
Published: October 2023

Abstract
The olive fruit fly Bactrocera oleae Rossi (Dip.: Tephritidae) is one of the most economically damaging pests of olives worldwide. The present study was conducted in Qazvin Province (Ghooshchi and Siahpoosh), Iran, between 2019 and 2021 to investigate seasonal fluctuations and the population's bio-ecology characteristics of B. oleae using sex pheromone traps and McPhail traps. Fruit sampling was also carried out to reveal pest development and the fruit infestation rate. The results showed that adult insects are active throughout the year, and their density varies depending on the weather conditions. In the areas where the study was conducted, there are three to four overlapping pest generations per year. In late spring and early summer, the oviposition of female insects on the fruits coincides with the hardening of the olive pit. Immature stages of the pest were observed in late May at different dates, indicating the beginning of the first generation of olive fruit flies. The second generation starts from late August to late September, and the third generation begins in early October. The population density and economic damage of the pest varied over the three years, depending on temperature, relative humidity, and orchard management. Cyrtoptyx latipes parasitized pest larvae at a maximum percentage of 2.16, which was very low.
Cutting temperature study in AISI D6 steel turning with carbide tool.
Authors: Silva Adriano Aguiar da , Pereira Igor C. 
Published: October 2023

Abstract
The high temperatures achieved in the machining of hardened steels generate high costs to the process, especially about the problems related to the wear suffered by the cutting tool that influence both economic viability and production performance, in return facilitates the machining of low machinability materials such as hardened steels. The objective of this work is to analyze the temperature behavior in the tool chip interface, through the thermocouple tool/part method. To understand the maximum temperatures reached, since the chip/tool interface temperature, the cutting parameters that will be varied are cutting speed, feed, depth of cut, rake angle and wear stage. From this, to evaluate the influence of the variation of the cutting speed on the average increase in temperature of 204°C during the tests.
Climate influences scrub typhus occurrence in Vellore, Tamil Nadu, India: Analysis of a 15-year dataset
Authors: Prakash John Antony Jude , Cruz Solomon D , Sreed Kotamreddy , Cheryl Lynette , Gunasekaran Karthik 
Published: October 2023

Abstract

Background Climate is one of the major factors determining the prevalence and seasonality of vector borne diseases like scrub typhus (ST). We analyzed, the association of the meteorological factors like temperature, rainfall and humidity with scrub typhus using the 15 years scrub typhus data from a tertiary care hospital in Vellore, South India. Methods Demographic data of permanent residents of Vellore, who had IgM ELISA results for scrub typhus for the time period of May 2005 to April 2020 were included. Meteorological data was correlated with the monthly scrub typhus cases; negative binomial regression model was used to predict the relation between scrub typhus occurrence and climate factors. Results Maximum number of ST cases were reported between the months August and February with October recording the highest number of cases. Elderly people, farmers, agricultural workers and housewives were associated with ST positivity significantly. For an increase of 1°C in mean temperature, the monthly ST cases reduced by 18.78% (95% CI: -24.12, -13.15%). On the contrary, for 1 percent increase in mean relative humidity (RH), there is an increase of 7.57% (95% CI: 5.44, 9.86%) of monthly ST cases. Similarly, an increase of 1mm of rainfall contributed to 0.50 to 0.70% of monthly ST cases (after two months) depending on the variables included in the analysis. Conclusion This study provides further information on the role of rainfall, temperature and humidity on the seasonality of scrub typhus in Vellore, South India. This baseline data will be useful for further analysis using spatio-temporal tools to better understand the seasonality in other parts of India.
Exploring Naringenin's Cancer-Fighting Potential: An In-depth In-silico Study of Prosomillet Metabolite Targeting the Human Epidermal Growth Factor Receptor
Authors: Kathirvel Pavitra , N Bharathi , N Saranya , Jayakanthan M , Vellaikumar S , V Anandhi , Sowdhamini R , Tiwari Vikas 
Published: October 2023

Abstract
Prosomillet, also known as Broomcorn millet, has emerged as a significant food source for people in temperate and tropical regions due to its drought-resistant nature and rich dietary and therapeutic benefits. However, minor millets remain underutilized, with limited research investigating their nutritional and medicinal properties, particularly their potential as an antiproliferative and antioxidant agent in combating various carcinogenic diseases. This study focuses on the metabolic profiling of Proso Millet using Gas Chromatography-Mass Spectrometry (GC-MS) analysis and the therapeutic potential of the natural metabolite Naringenin as an EGFR cancer cell inhibitor. The metabolites identified were subjected to in-silico analysis, involving molecular docking and virtual screening against the Epidermal Growth Factor Receptor (EGFR) protein (PDB ID: 3w33). A total of 68 phytocompounds from the Prosomillet (ATL-1) were screened, alongside five known FDA-approved cancer inhibitors, to explore the interactions between the cancer protein and the ligands. The docked complex revealed the binding energies between the peptide and the target molecule, suggesting their potential as candidate drugs for cancer treatment. Molecular dynamic simulation studies were carried out on the top-ranked molecule. The in-silico analyses indicate that naringenin has the potential to be a cutting-edge therapeutic candidate for the treatment of human cancer.
Rainfall-runoff modeling using machine learning in the urban watershed of Pishin Lora Basin, Balochistan (Pakistan)
Authors: Shah Ghunwa , Zaidi Arjumand , Qureshi Abdul Latif , Hussain Shahzad , Jokhio Rizwan , Aziz Tariq 
Published: October 2023

Abstract
Pishin Lora Basin (PLB) is one of the major and most water-scarce basins in the Balochistan province of Pakistan. The Pishin Lora River flowing through the basin supports agriculture and domestic water use. However, the available scientific research on hydrological modeling in the study area is either limited or outdated. The growing impact of climate change on the basin's hydrology has increased interest in forecasting, which requires flow prediction studies using innovative approaches. In this study, Artificial Neural Network (ANN), a machine learning (ML) data-driven approach, is utilized as an alternative to hydrological models. Multilayer perceptron (MLP) model was structured for the runoff prediction. The model's performance evaluation was done to check the accuracy of the prediction. Remotely sensed thirty-two years (1990–2022) observed daily, weekly, and monthly rainfall, humidity and temperature dataset of Modern-Era Retrospective analysis for Research and Applications-2 (MERRA-2) satellite were used as model inputs to predict the watershed's runoff as the output. Runoff data were generated using Soil Conservation Service Curve Number (SCS-CN) Method. Statistical tests were used for the performance evaluation of the model, including coefficient of determination (R2), mean absolute error (MAE) and root mean squared error (RMSE). Four input combinations were used for the prediction of runoff. With rainfall alone as a input the R2 for daily, weekly and monthly datasets were 0.734, 0.968 and 0.906 respectively. Compared to the daily dataset, the model performed better for the weekly and monthly datasets. This demonstrates that the model is effective at predicting the runoff.
Preexposure Prophylaxis to Eliminate HIV in Taiwan by 2030: A Modeling Study
Authors: Fang Chi-Tai , Wu Huei-Jiuan , Cheng Ya-Ping , Chen Yi-Hsuan , Chang Chia-Chen , Lo Tung 
Published: October 2023

Abstract
Preexposure prophylaxis (PrEP) demonstrated 86% efficacy in randomized trials. However, globally, PrEP remains underutilized. The role of PrEP in achieving HIV elimination has been underappreciated and understudied. In Taiwan, the HIV epidemic predominantly affects young, sexually active men who have sex with men (MSM). Our stochastic modeling indicates that the HIV test-and-treat strategy has minimal impact on HIV transmissions that occur during the acute HIV infection. In contrast, a PrEP program providing access to 50% of young, high-risk MSM will halve transmissions during the acute stage and suppress the basic reproduction number (R0) of HIV to below 1, thereby facilitating its elimination. Risk compensation (i.e., none of the PrEP users using condom), imperfect adherence (at 75%), or drug resistance (at a 1% rate) do not undermine such a program's effectiveness. Deterministic modeling further indicates that implementing a 50% coverage PrEP program will reduce the trajectory of the HIV epidemic in Taiwan to below the World Health Organization’s HIV elimination threshold (1/1,000 person-years) by 2030, and such a program is highly cost-saving from a societal perspective, yielding a benefit-cost ratio of 7.16. Our findings strongly support the broad administration of PrEP to high-risk, HIV-negative MSM to achieve HIV elimination by 2030.
Spatio-Temporal Variability of Atmospheric Aerosols Affecting Cloud Properties around Mangaluru along the Southwest Coast of India
Authors: Ahmed Aarif , Getachew Birhan , Manjunatha B.R. , Jose Jithin , Rajesha R. 
Published: October 2023

Abstract
The study analyzed the effect of aerosols on cloud properties in the summer monsoon-dominated region around Mangaluru along the southwest coast of India from 2001 to 2020. AOD (aerosol optical depth) and Angstrom Exponent (AE) datasets were used to examine aerosols' spatial and temporal distribution over the study area and the adjacent Arabian Sea. The back trajectories of the airmass computed from the hybrid single-particle lagrangian integrated trajectory (HYSPLIT) model indicate that this region is highly influenced by the marine airmass of the Arabian Sea, which is considerably contaminated by those emitted over the landmass, particularly from the anthropocentric region, throughout the year. Seasonally, the coarse particles especially dominate during the summer and, to some extent, during the spring, whereas the fine-mode aerosols especially dominate during the winter and autumn seasons. The latter types of aerosols gradually increased from 2001 to 2018, but a sudden decrease in the level was noticed in 2019–20 due to the COVID-19 lockdown. The correlation between AOD and cloud characteristics, i.e., cloud fraction (CF), cloud top pressure (CTP), cloud top temperature (CTT), and water vapor (WV), indicates that the positive correlation of AOD with CF and WV suggests that aerosols responsible for AOD are also responsible for cloud formation, especially in areas with high levels of industrial activity. In contrast, negative correlations with CTT and CTP suggest the dominance of sea salt and dust aerosols, which can scatter sunlight back into space and cool the atmosphere by lowering CTT and CTP, during monsoon season.
O-GlcNAcylation of Keratin 18 coordinates TCA cycle to promote cholangiocarcinoma progression
Authors: Xie Ran , Meng Xiangfeng , Zhou Yue , Xu Lei , Wang Changjiang , Tian Xiao , Zhang Xiang , Hao Yi , Cheng Bo , Wang Lei , Liu Jialin 
Published: October 2023

Abstract
Glycosylation in human cholangiocarcinoma (CCA) actively contributes to pathophysiological steps of tumor progression. Of note is the dynamic modification of proteins by O-linked β-N-acetyl-glucosamine (O-GlcNAcylation) that modulates various tumor-associated biological activities. By using a cutting-edge chemical proteomic methodology for intact glycopeptide analysis, we show herein that O-GlcNAcylation of Keratin 18 (K18) coordinates the tricarboxylic acid (TCA) cycle enzymes, namely isocitrate dehydrogenases (IDHs), to promote CCA progression. Mechanistically, site-specific O-GlcNAcylation of K18 on Ser 30 stabilizes K18, which benefits the expression of cell cycle checkpoints to enhance cell cycle progression and cell growth. Interaction with IDHs down-regulates the level of citrate and isocitrate, while up-regulates the level of α-ketoglutarate (α-KG). Our study thus expands the current understanding of protein O-GlcNAcylation, and adds another dimension of complexity to post-translational control over metabolism and tumorigenesis.
Optimizing carbon emissions of precast production in off-site construction: a multi-objective scheduling approach with group technology
Authors: Zheng Ruiyan , Li Zhongfu , Li Long , Ma Shengbin , Li Xiaodan 
Published: October 2023

Abstract
Faced with immense pressure to reduce carbon emissions, off-site construction (OSC) is considered as a sustainable alternative from conventional practices. However, challenged by component diversity and a sharp rise in demand, deficient management in off-site precast production struggles to effectively tackle real-world challenges of component grouping, coupled with insufficient attention to environmental impacts, ultimately resulting in falling short of expected benefits in OSC projects. Therefore, this study discusses carbon emissions and component grouping issues in off-site precast production. A multi-objective optimization framework is proposed, aiming to minimize carbon emissions and reduce tardiness/ earliness penalty while considering the incorporation of grouping technology for component grouping. The non-dominated sorting genetic algorithm II (NSGA-II), adjusted by adaptive population initialization strategy and group technology, is introduced for solving this problem, striking a balance between sustainability and penalty costs. Through a real-case analysis, the proposed approach demonstrates an average reduction of 37.5% in carbon emissions compared to rule-based scheduling methods, a 30.1% reduction compared to previous research methods, along with over 10% reduction in tardiness/ earliness penalty. This study enhances carbon efficiency from a production scheduling perspective and establishes an automated, practical method, fostering low-cost, high-efficiency green production for construction component enterprises, particularly for small and medium-sized enterprises, thereby promoting sustainable development in the construction industry.