bluuebunny/crossref_metadata_2025_split huggingface dataset:
Plasmodium immunotherapy combined with gemcitabine has a synergistic inhibitory effect on tumor growth and metastasis in murine Lewis lung cancer models
Authors: Chen Xiao , Tao Zhu , Liang Yun , Ma Meng , Adah Dickson , Ding Wenting , Chen Lili , Li Xiaofen , Dai Linglin , Fanuel Songwe , Zhao Siting , Hu Wen , Wu Donghai , Duan Ziyuan , Zhou Fang , Qin Li , Chen Xiaoping , Yang Zhaoqing 
Published: October 2023

ObjectiveOur previous studies have demonstrated that Plasmodium immunotherapy (infection) has antitumor effects in mice. However, as a new form of immunotherapy, this therapy has a weakness: its specific killing effect on tumor cells is relatively weak. Therefore, we tested whether Plasmodium immunotherapy combined with gemcitabine (Gem), a representative chemotherapy drug, has synergistic antitumor effects.MethodsWe designed subcutaneously and intravenously implanted murine Lewis lung cancer (LLC) models to test the antitumor effect of Plasmodium chabaudi ASS (Pc) infection in combination with Gem treatment and explored its underlying mechanisms.ResultsWe found that both Pc infection alone and Gem treatment alone significantly inhibited tumor growth in the subcutaneous model, and combination therapy was more effective than either monotherapy. Monotherapy only tended to prolong the survival of tumor-bearing mice, while the combination therapy significantly extended the survival of mice, indicating a significant synergistic effect of the combination. In the mechanistic experiments, we found that the combination therapy significantly upregulated E-cadherin and downregulated Snail protein expression levels, thus inhibiting epithelial-mesenchymal transition (EMT) of tumor cells, which may be due to the blockade of CXCR2/TGF-β-mediated PI3K/Akt/GSK-3β signaling pathway.ConclusionThe combination of Pc and Gem plays a synergistic role in inhibiting tumor growth and metastasis, and prolonging mice survival in murine lung cancer models. These effects are partially attributed to the inhibition of EMT of tumor cells, which is potentially due to the blockade of CXCR2/TGF-β-mediated PI3K/Akt/GSK-3β/Snail signaling pathway. The clinical transformation of Plasmodium immunotherapy combined with Gem for lung cancer is worthy of expectation.
Perilesional edema diameter associated with brain metastases as a predictive factor of response to radiotherapy in non-small cell lung cancer
Authors: Arrieta Oscar , Bolaño-Guerra Laura Margarita , Caballé-Pérez Enrique , Lara-Mejía Luis , Turcott Jenny G. , Gutiérrez Salvador , Lozano-Ruiz Francisco , Cabrera-Miranda Luis , Arroyave-Ramírez Andrés Mauricio , Maldonado-Magos Federico , Corrales Luis , Martín Claudio , Gómez-García Ana Pamela , Cacho-Díaz Bernardo , Cardona Andrés F. 
Published: October 2023

BackgroundDifferent prognostic scales exist in patients with brain metastasis, particularly in lung cancer. The Graded Prognostic Assessment for lung cancer using molecular markers (Lung-molGPA index) for brain metastases is a powerful prognostic tool that effectively identifies patients at different risks. However, these scales do not include perilesional edema diameter (PED) associated with brain metastasis. Current evidence suggests that PED might compromise the delivery and efficacy of radiotherapy to treat BM. This study explored the association between radiotherapy efficacy, PED extent, and gross tumor diameter (GTD).AimThe aim of this study was to evaluate the intracranial response (iORR), intracranial progression-free survival (iPFS), and overall survival (OS) according to the extent of PED and GT.MethodsOut of 114 patients with BM at baseline or throughout the disease, 65 were eligible for the response assessment. The GTD and PED sum were measured at BM diagnosis and after radiotherapy treatment. According to a receiver operating characteristic (ROC) curve analysis, cutoff values were set at 27 mm and 17 mm for PED and GT, respectively.ResultsMinor PED was independently associated with a better iORR [78.8% vs. 50%, OR 3.71 (95% CI 1.26–10.99); p = 0.018] to brain radiotherapy. Median iPFS was significantly shorter in patients with major PED [6.9 vs. 11.8 months, HR 2.9 (95% CI 1.7–4.4); p &lt; 0.001] independently of other prognostic variables like the Lung-molGPA and GTD. A major PED also negatively impacted the median OS [18.4 vs. 7.9 months, HR 2.1 (95% CI 1.4–3.3); p = 0.001].ConclusionHigher PED was associated with an increased risk of intracranial progression and a lesser probability of responding to brain radiotherapy in patients with metastatic lung cancer. We encourage prospective studies to confirm our findings.
Assessing the cardiac autonomic response to bicycle exercise in Olympic athletes with different loads of endurance training: new insights from statistical indicators based on multilevel exploratory factor analysis
Authors: Solaro Nadia , Pagani Massimo , Spataro Antonio , Lucini Daniela 
Published: October 2023

Aim:The mechanisms governing the organism’s response to exercise are complex and difficult to study. Spectral analysis of heart rate variability (HRV) could represent a convenient methodology for studying humans’ autonomic nervous system (ANS). However, difficulties in interpreting the multitude of correlated HRV-derived indices, mainly when computed over different time segments, may represent a barrier to its usage. This preliminary investigation addressed to elite athletes proposes a novel method describing the cardiac autonomic response to exercise based on multilevel exploratory factor analysis (MEFA), which reduces the multitude of HRV-derived indices to fewer uncorrelated ANS indicators capable of accounting for their interrelationships and overcoming the above difficulties.Methods:The study involved 30 Italian Olympic athletes, divided into 15 cyclists (prevalent high-intensity endurance training) and 15 shooters (prevalent technical training with low-intensity endurance component). All athletes underwent a complete test of a dynamic protocol, constituted by a rest-stand test followed by a stepwise bicycle stress test subdivided into a single bout of progressive endurance (from aerobic to anaerobic) exercise and recovery. Then, by spectral analysis, values of 12 ANS proxies were computed at each time segment (9 epochs in all) of the complete test.Results:We obtained twoglobalANS indicators (amplitude and frequency), expressing the athletes’ overall autonomic response to the complete test, and threedynamicANS indicators (amplitude, signal self-similarity, and oscillatory), describing the principal dynamics over time of the variability of RR interval (RRV). Globally, cyclists have significantly higher amplitude levels (median ± MAD: cyclists 69.9 ± 20.5; shooters 37.2 ± 19.4) and lower frequency levels (median ± MAD: cyclists 37.4 ± 14.8; shooters 78.2 ± 10.2) than shooters, i.e., a parasympathetic predominance compared to shooters. Regarding the RRV dynamics, the signal self-similarity and oscillatory indicators have the strongest sensitivity in detecting the rest-stand change; the amplitude indicator is highly effective in detecting the athletes’ autonomic changes in the exercise fraction; the amplitude and oscillatory indicators present significant differences between cyclists and shooters in specific test epochs.Conclusion:This MEFA application permits a more straightforward representation of the complexity characterizing ANS modulation during exercise, simplifying the interpretation of the HRV-derived indices and facilitating the possible real-life use of this non-invasive methodology.
Effects of nitrogen stress and nitrogen form ratios on the bacterial community and diversity in the root surface and rhizosphere of Cunninghamia lanceolata and Schima superba
Authors: Wang Yanru , Li Xiaoyu , Quan Xiaoqiang , Liang Haiyan , Wang Lidong , Yan Xiaoli 
Published: October 2023

BackgroundThe bacterial communities of the root surface and rhizosphere play a crucial role in the decomposition and transformation of soil nitrogen (N) and are also affected by soil N levels and distribution, especially the composition and diversity, which are sensitive to changes in the environment with high spatial and temporal heterogeneity of ammonium N (NH4+-N) and nitrate N (NO3--N).MethodsOne-year-old seedlings of Cunninghamia lanceolata and Schima superba were subjected to N stress (0.5 mmol L-1) and normal N supply (2 mmol L-1), and five different N form ratios (NH4+-N to NO3--N ratio of 10:0, 0:10, 8:2, 2:8, and 5:5) were created. We analyze the changes in composition and diversity of bacteria in the root surface and rhizosphere of two tree species by high-throughput sequencing.ResultsDifferences in the composition of the major bacteria in the root surface and rhizosphere of C.lanceolata and S. superba under N stress and N form ratios were not significant. The dominant bacterial phyla shared by two tree species included Proteobacteria and Bacteroidota. Compared to normal N supply, the patterns of diversity in the root surface and rhizosphere of two tree species under N stress were distinct for each at five N form ratios. Under N stress, the bacterial diversity in the root surface was highest at NH4+-N to NO3--N ratio of 10:0 of C. lanceolata, whereas in the root surface, it was highest at the NH4+-N to NO3--N ratio of 0:10 of S. superba. The NH4+-N to NO3--N ratio of 5:5 reduced the bacterial diversity in the rhizosphere of two tree species, and the stability of the bacterial community in the rhizosphere was decreased in C. lanceolata. In addition, the bacterial diversity in the root surface was higher than in the rhizosphere under the N stress of two tree species.ConclusionThe bacterial compositions were relatively conserved, but abundance and diversity changed in the root surface and rhizosphere of C. lanceolata and S. superba under N stress and different N form ratios. The heterogeneity of ammonium and nitrate N addition should be considered for N-stressed environments to improve bacterial diversity in the rhizosphere of two tree species.
Work out of office: how and when does employees’ self-control influence their remote work effectiveness?
Authors: Qi Lei , Xu Yuping , Liu Bing 
Published: October 2023

IntroductionThe purpose of this study is to understand the positive effects of employees’ self-control on their self-efficacy and work effectiveness in the context of remote work, as well as social support (organizational support, interaction with supervisors, and family support) moderating role on such positive effects.MethodsBased on social cognitive theory, this study collects two-phase data with a sample of 240 remote workers.ResultsThe results show that employees’ self-control positively influences their remote work self-efficacy, which in turn positively increases their remote work effectiveness. Moreover, perceived organizational support, interaction with supervisors, and family support strengthen the effect of self-control on remote work self-efficacy.DiscussionFirst, this study explores the mechanism of self-control on remote work effectiveness, highlights the importance of self-control in remote work, and provides guidance for employees to improve remote work effectiveness. Second, this study discusses the mediating role of remote work self-efficacy between self-control and remote work effectiveness and reveals the psychological mechanism of employees’ self-control in remote work. Finally, this study comprehensively considers three types of support from work and family and analyzes the interaction between internal control and external support on remote work self-efficacy, which provides suggestions for enhancing employees’ confidence in remote work.
Depression and risk of sarcopenia: a national cohort and Mendelian randomization study
Authors: Zhong Qian , Jiang Lisha , An Kang , Zhang Lin , Li Shuangqing , An Zhenmei 
Published: October 2023

BackgroundDepression and the increased risk of sarcopenia are prevalent among the elderly population. However, the causal associations between these factors remain unclear. To investigate the potential association between depression and the risk of sarcopenia in older adults, this study was performed.MethodsIn the baseline survey, a total of 14,258 individuals aged 40 and above from the China Health and Retirement Longitudinal Study (2015) participated. We initially described the baseline prevalence of the disease. Then, logistic regression and restricted cubic spline (RCS) regression were conducted to assess the relationship between depression and sarcopenia. Subgroup analysis was performed to validate the robustness of the findings. Additionally, we conducted Mendelian randomization analysis using the inverse variance weighting estimator to assess the causal relationship between depression and sarcopenia. Furthermore, we adopted six methods, including MR-Egger, simple median, weighted median, maximum likelihood, robust adjusted profile score (RAPS), and MR Pleiotropy Residual Sum and Outlier (MR-PRESSO), for sensitivity analyses.ResultsDepression patients exhibited higher risks of sarcopenia in all five models adjusting for different covariates (P &lt; 0.05). The RCS analysis demonstrated a linear relationship between depression and sarcopenia (P &lt; 0.05). In the subgroup analysis, increased risk was observed among participants aged 60−70, married or cohabiting individuals, non-smokers, non-drinkers, those with less than 8 h of sleep, BMI below 24, and individuals with hypertension (all P &lt; 0.05). Mendelian randomization results revealed that genetically proxied depression led to a reduction in appendicular skeletal muscle mass (all P &lt; 0.05).ConclusionOur study provides observational and causal evidences that depression can lead to sarcopenia. This finding emphasizes the importance of timely identification and management of depression, as well as implementing targeted educational programs as part of comprehensive strategies to prevent sarcopenia.
Functional fantasies: the regulatory role of grandiose fantasizing in pathological narcissism
Authors: Finch Ellen F. , Hooley Jill M. 
Published: October 2023

IntroductionPathological narcissism is characterized by maladaptive efforts to maintain a bolstered but fragile sense of self. Clinical theory suggests that grandiose fantasizing may be one form of this self-regulation. However, no empirical research has directly assessed the regulatory function of grandiose fantasizing in narcissism. Here, we examine (1) whether people scoring higher in narcissism choose to engage in grandiose fantasizing to regulate themselves when they are feeling down and (2) whether grandiose fantasizing is a more efficacious self-esteem and affect regulator for people scoring higher in narcissism than it is for those scoring lower in narcissism.MethodsAdult participants (N = 189) completed a self-report measure of narcissism and were randomized to either a negative mood induction or filler task condition. Then, participants wrote about a future event to make themselves feel better, choosing between a positive affect word or a grandiose word to guide their writing. Throughout the study, participants reported their state positive and negative affect and self-esteem. A secondary sample (N = 128) of adult participants rated the future event writing of the original participants.ResultsSupporting the validity of the study design, grandiose future events significantly differed from positive future events (e.g., they were rated by independent raters as less plausible, more ambitious, more active, and occurring further in the future). Participants scoring higher in narcissism and participants who experienced larger increases in negative affect were more likely to choose to engage in grandiose fantasizing. Grandiose fantasizing was more effective at decreasing negative affect among participants scoring higher in narcissism than those scoring lower in narcissism, whereas positive future thinking was equally effective at decreasing negative affect across levels of narcissism.DiscussionThis study demonstrates that people scoring higher in narcissism are more likely to choose to engage in grandiose fantasizing to make themselves feel better. It further demonstrates that grandiose fantasizing is a more efficacious affect regulator for those scoring higher in narcissism.
Impact of the 7/14/2016 Nice terrorist attack on pediatric emergency department visits thanks to syndromic surveillance: a descriptive study
Authors: Fernandez Arnaud , Meurice Laure , Franke Florian , Vuillermoz Cecile , Gindt Morgane , Askenazy Florence , Vandentorren Stéphanie 
Published: October 2023

ObjectiveStudy the impact of 14th July 2016 Nice terrorist attack on Pediatric Emergency Department (PED) visits by youth under 18 years of age.MethodsPED visits diagnoses (ICD10) were clustered and analyzed based on retrospective data from the syndromic surveillance system of the Children’s university hospital of Nice (Southern France). The studied period ranges from 2013 to 2019, i.e., 3 years before and after the terrorist attack of 14th July 2016.ResultsAmong 416,191 PED visits, the number of visits for stress in 4–17 years old appeared to increase in the 3 years after the attack compared to the 3 years before, particularly in September 2016 (acute effect) with 11 visits compared to an average of 2.3 visits per month from September 2013 to 2016 (p = 0.001827). In September 2017, we noticed 21 visits compared to an average of 4.8 visits per month during the following period (2013–2019). In 2017, PED visits for stress among 4–17 year olds were higher in comparison to the other years of the study: 107 visits compared to an annual average of 57.ConclusionTo our knowledge, this is the first study of the use of the pediatric care system before and after a terrorist attack involving syndromic surveillance. This suggests acute and long-term effects of the terrorist attack on PED use by youth for mental health issues. Further studies of the pediatric care system involving syndromic surveillance are needed in the context of mass violent events, such as terrorist attacks.
New Research on the Bacillus anthracis Genetic Diversity in Siberia
Authors: Timofeev Vitalii , Bakhteeva Irina , Khlopova Kseniya , Mironova Raisa , Titareva Galina , Goncharova Yulia , Solomentsev Viktor , Kravchenko Tatiana , Dyatlov Ivan , Vergnaud Gilles 
Published: October 2023

Anthrax is a particularly dangerous infection of humans and ungulates caused by the Gram-positive spore-forming bacterium Bacillus anthracis. The highly monomorphic and clonal species B. anthracis is commonly divided into three main lineages, A, B, and C, which in turn are divided into several canSNP groups. We report here a phylogenetic analysis based on the whole-genome sequence (WGS) data of fifteen strains isolated predominantly in Siberia or Central and Southern Russia. We confirm the wide distribution of the cluster of strains of the B.Br.001/002 group, endemic to the Russian Arctic, which is also present in the steppe zone of Southern Siberia. We characterize additional branches within the major A.Br.001/002 polytomy comprising the A.Br.Ames and A.Br.Sterne lineages, one of which is identified in the Arctic.
Optimal inequalities related to the logarithmic, identric, arithmetic and harmonic means
Authors: Xia Wei-feng , Yu-Ming Chu 
Published: October 2023

The logarithmic mean \(L(a,b)\), identric mean \(I(a,b)\), arithmeticmean \(A(a,b)\) and harmonic mean \(H(a,b)\) of two positive real values \(a\) and \(b\) are defined by\begin{align*}\label{main}&L(a,b)=\begin{cases}\tfrac{b-a}{\log b-\log a},& a\neq b,\\a,&a=b,\end{cases}\\&I(a,b)=\begin{cases}\tfrac{1}{{\rm e}}\left(\tfrac{b^b}{a^a}\right)^{\tfrac{1}{b-a}},& a\neq b,\\a,&a=b,\end{cases}\end{align*}\(A(a,b)=\tfrac{a+b}{2}\) and \(H(a,b)=\tfrac{2ab}{a+b}\), respectively. In this article, we answer the questions: What are the best possible parameters \(\alpha_{1},\alpha_{2},\beta_{1}\) and \(\beta_{2}\), such that \(\alpha_{1}A(a,b)+(1-\alpha_{1})H(a,b)\leq L(a,b)\leq\beta_{1}A(a,b)+(1-\beta_{1})H(a,b)\) and \(\alpha_{2}A(a,b)+(1-\alpha_{2})H(a,b)\leq I(a,b)\leq\beta_2A(a,b)+(1-\beta_{2})H(a,b)\) hold for all \(a,b>0\)?
Using an Escape Room activity to Enhance the Motivation of Undergraduate Life Science Students in Mathematics Classes - A Case Study
Authors: Pais Sónia , Sousa Ana Elisa , Pires Ana 
Published: October 2023

Mathematics is one of the school subjects where demotivation, dislike and failure are frequent concerns. To address this, it is important to actively engage students in the classroom and employ resources that make math classes more appealing and captivating, leading to meaningful learning experiences.
Active, cooperative, and participative learning methods should be prioritized over traditional didactic teaching and the mere transmission of knowledge. Active learning methods offer alternative approaches to the conventional lecture format, actively involving students in the learning process. The concept of an escape room, a gaming experience where participants must solve challenges to escape from a locked room, has gained popularity in educational contexts. The educational escape room is an extension of this concept, aiming to promote real-time problem-solving, teamwork, and discovery of clues and mysteries to facilitate active learning. By engaging in various tasks within a room, students work together in teams, fostering an active learning environment. The educational escape room offers several benefits, including the enhancement of problem-solving skills, student performance, and motivation. By incorporating gamification strategies into teaching and learning processes, this approach proves to be an effective way of promoting active learning in mathematics.
In this paper, we present a case study that explores the use of an educational escape room with first-year undergraduate students from a Portuguese higher education institution, with the goal of improving their mathematical problem-solving skills. The study aims to evaluate how escape rooms can contribute to increased student motivation.
To assess the perception of students regarding this escape room methodology, a quantitative survey was conducted. The findings indicate that using the escape room as an educational approach effectively increased student interest and improved learning outcomes in mathematics.
GAMA: A Multi-graph-based Anomaly Detection Framework for Business Processes via Graph Neural Networks
Authors: Guan Wei , Cao Jian , Gu Yang , Qian Shiyou 
Published: October 2023

<p>Anomalies in business processes are inevitable for various reasons such as system failures and operator errors. Detecting anomalies is important for the management and optimization of business processes. In this paper, we propose a multi-<strong>G</strong>raph based <strong>A</strong>nomaly detection fra<strong>M</strong>ework for business processes via gr<strong>A</strong>ph neural networks, named GAMA. GAMA makes use of structural process information and attribute information in a more integrated way. In GAMA, multiple graphs are applied to model a trace in which each attribute is modelled as a separate graph. In particular, the graph constructed for the special attribute <em>activity</em> reflects the control flow. Then GAMA employs a multi-graph encoder and a multi-sequence decoder on multiple graphs to detect anomalies in terms of the reconstruction errors. Moreover, three teacher forcing styles are designed to enhance GAMA's ability to reconstruct normal behaviours and thus improve detection performance. We conduct extensive experiments on both synthetic logs and real-life logs. The experiment results demonstrate that GAMA outperforms state-of-the-art methods for both trace-level and attribute-level anomaly detection. </p>