bluuebunny/crossref_metadata_2025_split huggingface dataset:
Reduced mortality associated to cementless total hip arthroplasty in femoral neck fracture
Authors: Pangaud Corentin , Pauly Vanessa , Jacquet Christophe , Orleans Veronica , Boyer Laurent , Khakha Raghbir , Argenson Jean Noël , Ollivier Matthieu 
Published: October 2023

AbstractMortality related to femoral neck fractures remains a challenging health issue, with a high mortality rate at 1 year of follow-up. Three modifiable factors appear to be under control of the surgeon: the choice of the implant, the use of cement and the timing before surgery. The aim of this research project was to study the impact on mortality each of these risk factors play during the management of femoral neck fractures. A large retrospective epidemiological study was performed using a national database of the public healthcare system. The inclusion criteria were patients who underwent joint replacement surgery after femoral neck fracture during the years 2015 to 2017. All data points were available for at least 2 years after the fracture. The primary outcome was mortality within 2 years following the surgery. We evaluated the association between mortality and the type of the implant hemiarthroplasty (HA) versus total hip arthroplasty (THA), cemented versus non cemented femoral stem as well as the timing from fracture to surgical procedure. A multivariate analysis was performed including age, gender, comorbidities/autonomy scores, social category, and obesity. We identified 96,184 patients who matched the inclusion criteria between 2015 and 2017. 64,106 (66%) patients underwent HA and 32,078 (33.4%) underwent THA. After multivariate analysis including age and comorbidities, patients who underwent surgery after 72 h intra-hospital had a higher risk of mortality: Hazard Ratio (HR) = 1.119 (1.056–1.185) p = 0.0001 compared to the group who underwent surgery within 24 h. THA was found to be a protective factor HR = 0.762 (0.731–0.795) p < 0.0001. The use of cement was correlated with higher mortality rate: HR = 1.107 (1.067–1.149) p < 0.0001. Three key points are highlighted by our study in the reduction of mortality related to femoral neck fracture: the use of hemiarthroplasty a surgery performed after 48 h and the use of cement for femoral stem fixation adversely affect mortality risk.
Association between breakfast frequency and metabolic syndrome among young adults in South Korea
Authors: Kim Hyo Myoung , Kang Hyun Jung , Lee Dong Hoon , Jeong Su-Min , Joh Hee-Kyung 
Published: October 2023

AbstractSkipping breakfast is highly prevalent but it is not clear whether breakfast frequency is associated with metabolic syndrome in young adults. We aimed to assess the association between breakfast frequency and metabolic syndrome in Korean young adults. This cross-sectional study was based on health check-up data of university students aged 18–39 years between 2016 and 2018. Participants were stratified into three groups by breakfast frequency (non-skipper, skipper 1–3 days/week, skipper 4–7 days/week). Multivariable-adjusted logistic regression was used to calculate odds ratios (ORs) and 95% confidence intervals (CIs) of metabolic syndrome. Out of 12,302 participants, 56.8% skipped breakfast at least 4 days/week. Metabolic syndrome prevalence was higher in those skipping breakfast for 4 or more days/week compared to non-skipper. (3.1% vs 1.7%) In the age- and sex-adjusted model, individuals skipping breakfast for 4–7 days per week had a higher OR of metabolic syndrome (OR 1.73, 95% CI 1.21–2.49) compared to non-skipper. Although this association became insignificant (OR 1.49, 95% CI 0.99–2.23) after a fully adjusted multivariable model, trends of positive association between frequency of breakfast skipping and metabolic syndrome was significant (P for trend = 0.038). Frequent breakfast skipping was associated with higher odds of metabolic syndrome in young adults. Further longitudinal studies in the long term are needed to understand the association of meal patterns with metabolic syndrome.
Impact of humid climate on rheumatoid arthritis faecal microbiome and metabolites
Authors: Wang Dingnan , Zheng Zhili , Yu Han , Dou Dou , Gao Yining , Xu Shuang , Li Zhiming , Sun Lili , Qiu Xudong , Zhong Xianggen 
Published: October 2023

AbstractStudies have shown that high humidity is a condition that aggravates the pain of rheumatoid arthritis (RA), but the relevant mechanism is controversial. Currently, there is a lack of experimental animal studies on high humidity as an adverse factor related to the pathogenesis of RA. We used healthy SD rats and collagen-induced arthritis (CIA) rats to investigate the effects of high humidity on arthritis. Integrated metabolomics analyses of faeces and 16S rRNA sequencing of the faecal microbiota were performed to comprehensively assess the diversity of the faecal microbiota and metabolites in healthy and CIA rats. In this study, high humidity aggravated arthritis in CIA rats, which manifested as articular cartilage lesions, increased arthritis scores, and an increase in proinflammatory cytokines. High humidity had a certain effect on the articular cartilage extent, arthritis score and proinflammatory cytokines of healthy rats as well. Furthermore, high humidity caused significant changes in faecal microbes and metabolites in both healthy and CIA rats. 16S rRNA sequencing of faecal samples showed that high humidity increased the amount of inflammation-related bacteria in healthy and CIA rats. Faecal metabolomics results showed that high humidity significantly altered the level of faecal metabolites in healthy rats and CIA rats, and the changes in biological functions were mainly related to the inflammatory response and oxidative stress. Combined analysis showed that there was a strong correlation between the faecal microbiota and faecal metabolites. High humidity is an adverse factor for the onset and development of RA, and its mechanism is related to the inflammatory response and oxidative stress. However, the question of how high humidity impacts RA pathogenesis needs to be further investigated.
Simulation and multi-objective optimization of the dimethyl carbonate production process
Authors: Maleki Ali , Bahadori Fatemeh 
Published: October 2023

AbstractGreenhouse gases such as CO2 are considered effective materials in global warming due to their high absorptivity. So, lowering atmospheric CO2 is one of the most practical strategies. Utilizing carbon dioxide in chemical processes is an applicable method. In this study, Aspen HYSYS 10 was used to investigate how carbon dioxide can be added to the process of dimethyl carbonate production, and the affective parameters of the process, including temperature, residence time, feed ratio, and recycle ratio, were evaluated. It was observed that the production of DMC grew as temperature rose. The simulation results also revealed that a maximum conversion of roughly 8% was attained in the MeOH/EC. Additionally, boosting the recycle ratio is detrimental, and the impact of temperature and MeOH/EC has been enhanced by increasing the residence time. The interactions of the above parameters have been studied by Design Expert 12. The optimum value of effective parameters for the production of dimethyl carbonate has been obtained as follows: temperature of 164.7° C, recycle ratio of 0.2, residence time of 139.45 min, and feed ratio of 5.9%, leading to the conversion of 70%.
Identifying the potential genes in alpha synuclein driving ferroptosis of Parkinson’s disease
Authors: Wang Min , Li Taole , Gao Rong , Zhang Yu , Han Yanqing 
Published: October 2023

AbstractParkinson’s disease (PD) is a common neurodegenerative disease with aggregation of α-synuclein (α-syn) in substantia nigra (SN). The association between the α-syn and ferroptosis in PD remains unclear. GSE49036 was obtained from the Gene Expression Omnibus (GEO) database and intersected with ferroptosis genes. Bioinformatics analysis was used to identify the potential differentially expressed genes (DEGs) included the development of Gene set enrichment analysis (GSEA), Kyoto Encyclopedia of Genes and Genomes (KEGG) and protein–protein interaction (PPI) network. We screened 8 key genes were modulated and crosslinked by 238 miRNAs. Additionally, 5 hub genes were predicted and 38 lncRNAs targeting 3 key miRNAs were revealed. Finally, 3 hub genes (PIK3CA, BRD4, ATM) and the key lncRNA (NEAT1) were verified in neurotoxic PD models. The in vitro experiments showed that PIK3CA and ATM were significantly upregulated or the BRD4 was downregulated in the rotenone treatment and they could be rescued by the specific ferroptosis inhibitor, liproxstatin-1. The expression of the key lncRNA NEAT1 were consistent with the hub genes in same models. This study identified the proposed NEAT1-PIK3CA/ATM ceRNA network may be a specific biomarker in α-syn driving ferroptosis as well as to predict clinical outcomes and therapeutic targets in PD patients.
The relationship between albumin corrected anion gap levels and mortality in patients with asthma in the ICU
Authors: Wang Shidong , Teng Hong , Han Hongyan , Xu Yunjie 
Published: October 2023

AbstractAlthough previous studies have suggested that albumin-corrected anion gap (ACAG) may be a predictor of mortality in critically ill patients in intensive care unit (ICU), its utility in the context of asthma has not been definitively established. In this study, baseline data, albumin concentration, anion gap (AG) and 30-d mortality data were retrieved from the Medical Information Mart for Intensive Care IV database (MIMIC-IV) for patients with asthma in the intensive care unit. Receiver operating characteristic (ROC) curves were constructed to analyze the predictive ability of ACAG and AG. The risk of 30-day mortality among patients with ACAG and asthma was analyzed using a restricted cubic spline (RCS) plot. Decision curve analysis (DCA) was used to evaluate the clinical usefulness of ACAG as a prognostic factor for 30-day mortality. Subsequently, subgroup analysis was conducted to explore potential variations in the relationship between ACAG and 30-day mortality based on factors such as sex, age, whether the asthma was acute, and other co-morbidities. Our study reveals that ACAG is a significant independent predictor of 30-day mortality in asthmatic patients receiving intensive care. The area under the AUC curve for ACAG was found to be 0.703, which is higher than that of AG, indicating that ACAG has a better predictive ability for 30-day mortality in this population. Furthermore, higher levels of ACAG were found to be associated with increased risk of 30-day mortality in asthmatic patients. In addition, decision curve analysis (DCA) demonstrated that the net benefit of ACAG was greater than that of AG. These findings suggest that ACAG may be a valuable prognostic factor for predicting 30-day mortality in asthmatic patients in the ICU. Our study provides evidence that ACAG is associated with an increased risk of 30-d mortality and has better predictive value in patients with combined asthma who are admitted to the ICU than AG.
Abortion in the First Trimester. Guideline of the DGGG (S2k-Level, AWMF Registry No. 015-094, December 2022) – Part 1 with Recommendations on Care Structures,
Information and Advice on Decision-Making, Measures Before Abortion and Medical Abortion
Authors: David Matthias , Achtenhagen Anne , Bamberg Christian , Bormann Cornelia , Felderhoff-Müser Ursula , Groth Sylvia , Hänel Kristina , König Klaus , Korell Matthias , Michl Susanne , Redler Silke , Schleußner Ekkehard , Seyler Helga , Wallwiener Markus , Wallwiener Stephanie 
Published: October 2023

Abstract
Purpose The aim was to develop evidence-based recommendations where possible. The guideline presents the medical principles and scientific evidence for indications, the counselling
of affected women, performing terminations, the choice of method, and the care and monitoring of a terminated pregnancy up until week 12 + 0 of gestation p. c.
Methods In accordance with the requirements for S2k-guidelines, the contents of the guideline were drafted following a systematic search of the literature by a representative
interdisciplinary group of experts. Guideline authors held several formal meetings under the auspices of the German Society for Gynaecology and Obstetrics (DGGG) during which the contents of
the guideline were finalised and agreed upon.
Recommendations A total of 61 recommendations are provided, covering care structures, provision of information and counselling to support decision-making, the measures to be taken
before terminating the pregnancy, and medical termination of the pregnancy.
Die S2e-Leitlinie Schultersteife
Authors: Dehlinger Friedrich , Bökeler Ulf , Brandt Hanna , Brunnader Lars , Eden Lars , Pfingsten Andrea , Prill Robert 
Published: October 2023

ZusammenfassungDas Krankheitsbild der „Frozen Shoulder“ gibt nach wie vor viele Rätsel auf. Um den aktuellen Stand der Erkenntnisse zu Ätiologie, Diagnostik und Behandlung darzustellen und den dabei beteiligten Berufsgruppen Handlungsempfehlungen zu bieten, wurde von der DGOU und der DVSE eine Arbeitsgruppe gebildet, die eine deutschsprachige, evidenzbasierte Leitlinie erstellt hat, die 2022 bei der AWMF veröffentlicht wurde. Im Folgenden werden die Entstehung und die wichtigsten Ergebnisse zusammengefasst.
Troubleshooting in der Kieferorthopädie: Strategien zur
Überwindung von Limitationen in der
Kieferorthopädie
Authors: Sabbagh Aladin , Sabbagh Hisham 
Published: October 2023

ZusammenfassungTrotz neuer innovativer Apparaturen und aller Weiterentwicklungen
kieferorthopädischer Mechaniken bestehen insbesondere bei der Behandlung
atypischer oder ausgeprägter dentaler und skeletaler Fehlstellungen
weiterhin Limitationen in der Behandlung sowohl mit festsitzenden Apparaturen
als auch mit den Alignern.Auch die Behandlung von Patientinnen und Patienten mit mangelnder
Therapieadhärenz ist eine tägliche Herausforderung, die
häufig die Anwendung einer kooperationsunabhängigen Technik
erfordert.Dieser Artikel beschreibt diverse praxisgerechte Strategien zur
Überwindung von technischen, funktionellen und
interdisziplinären Einschränkungen.
Based on Clinical Research Matrix Metalloprotease (MMP) Inhibitors to
Promote Diabetic Wound Healing
Authors: Yadav Jagat Pal 
Published: October 2023

AbstractChronic inflammation is a common factor in obesity, diabetes mellitus, and the
complications of diabetes, including diabetic wounds. These ulcers are
characterized by persistent lesions that are challenging to heal, significantly
decreasing patients’ quality of life and imposing a substantial
financial burden on society. MMP are zinc endopeptidases that play a role in
wound healing in response to various stimuli, including diabetes mellitus. MMP
levels fluctuate throughout the wound healing process in diabetic
patients' serum, skin tissues, and wound fluid, indicating their
potential as biomarkers for diabetic foot ulcers. Targeting MMP has emerged as a
promising strategy for treating diabetic wounds, as these enzymes are involved
in critical biological processes related to wound healing, including
extracellular matrix secretion, angiogenesis, granulation tissue formation,
collagen growth, re-epithelization, inflammatory response, and oxidative
stress.
Verlaufsdiagnostik des Knochenstoffwechsels unter verschiedenen
Therapieformen
Authors: Obermayer-Pietsch Barbara , Fößl Ines 
Published: October 2023

ZusammenfassungOsteoporose ist per se eine chronische Erkrankung, daher sind neben
nichtpharmakologischen Interventionen (z. B. hinsichtlich
Ernährung und Bewegung) vor allem medikamentöse Behandlungen
durch Antiresorptiva, osteoanabole oder dual wirksame Medikamente im
individuellen Kontext für viele Jahre zu planen. Für ein
Langzeit-Monitoring dieser Therapien kommen bildgebende Verfahren wie die
Knochendichtemessung, Risiko-Algorithmen, aber auch die Messung von
Knochenstoffwechselmarkern in Betracht. Während Knochendichtemessungen
aufgrund der nur langsamen Umstellung der Knochenstruktur und -dichte in
mehrjährigen Abständen sinnvoll sind, ermöglichen
Labormessungen als Surrogatmarker eine Momentaufnahme des individuellen
Knochenumsatzes und die Beurteilung der Medikamentenwirkung oder eines Risikos
bei Therapiepause in wesentlich kürzeren Abständen und mit wenig
Aufwand. Im Folgenden werden Labormarker des Knochenstoffwechsels in Hinblick
auf Langzeittherapie, Kombinations- oder Sequenztherapie und das Management von
Therapiepausen hin beleuchtet, um individuelle Behandlungsstrategien für
Osteoporose-Betroffene planen und kontrollieren zu können. Dabei wird
auch auf spezielle Personengruppen bzw. sekundäre Formen von Osteoporose
eingegangen und auf neue Entwicklungen für die Zukunft des
Osteoporose-Monitorings hingewiesen.
Review of the Total Synthesis of the Aromatic Abietane Diterpenoid Ferruginol
Authors: Huang Jian , Chen Yang , Li Mengran , Chen Peng , Liu Haoqi 
Published: October 2023

AbstractThe biological properties and synthesis of ferruginol as a classical abietane-type diterpenoid with an aromatic C ring are reviewed. A strategy overview from 1954 to 2023 toward the total synthesis of ferruginol may provide some references for the future design and synthesis of new diterpenoids natural products.1	Introduction2	Biological Activity of Ferruginol3	Strategies toward the Total Synthesis of Ferruginol3.1	Bogert–Cook Synthesis3.2	Robinson Annulation3.3	Domino Synthesis3.4	Intramolecular Friedel–Crafts Alkylation3.5	Oxidative Free-Radical Cyclization3.6	Polyene Cyclization4	Conclusion and Perspectives
Bismuth-Centered Radical Species: Access and Applications in ­Organic Synthesis
Authors: Lichtenberg Crispin , Martínez Sebastián 
Published: October 2023

AbstractRecent advances in the isolation of tamed bismuth radicals and the selective in situ generation of highly reactive bismuth radicals have set the stage for the application of these compounds in organic and organometallic synthesis and catalysis. Here, we provide a summary of the methodological approaches in the field. Important strategies for accessing bismuth radical species are presented and key examples of their applications in organic synthesis are outlined, highlighting how this class of compounds has emerged as new set of valuable tools for synthetic practitioners.1	Introduction2	Generation of Bismuth Radical Species by Homolysis2.1	Temperature-Induced Homolysis2.2	Light-Induced Homolysis2.3	Light-/Temperature-Induced Bi–C Homolysis of Polar Oxidative Addition Complexes3	Applications of Bismuth-Centered Radical Species in Organic Synthesis3.1	Bismuth-Catalyzed Cycloisomerization of Iodo Olefins3.2	Controlled Radical Polymerization Reactions3.3	Bismuth-Promoted Pn–Pn and C–S Coupling3.4	Bismuth-Catalyzed Dehydrocoupling of Silanes with TEMPO3.5	Bismuth-Catalyzed C–N Coupling with Redox-Active Electrophiles3.6	Bismuth-Catalyzed Giese-Type Coupling Reactions3.7	Oxidative Addition of Aryl Electrophiles to Photoactive Bismuthinidenes4	Conclusions
Evaluation of the Results of Septum Extension Batten Graft in Patients Referred for Septorhinoplasty
Authors: Hosnani Hamidreza , Bastaninez Shahin , Golchin Amirbahador , Givzadeh Hamed 
Published: October 2023

Abstract
Introduction Correction of caudal septal deviations has always been a challenging subject in septorhinoplasty. The septum batten extension graft (SBEG) is a new graft that has potential properties in rhinoplasty. However, few reports have evaluated the surgical outcomes of this technique.
Objective The purpose of this study was to evaluate the effectiveness of SBEG in correcting caudal septal deviation.
Methods This cross-sectional study was conducted on patients with caudal septal deviation undergoing septorhinoplasty using SBEG at 2 different hospitals in 2019. We then retrospectively reviewed medical records and photographs of 50 patients at the preoperative period, as well as at 1-month, and 12-month postoperatively. Gross changes in nasolabial angle, columellar show, nasal tip projection, and dorsal nasal deviation were evaluated by a photographic analysis method, and nasal obstruction was assessed by patient satisfaction with breathing.
Results There was a significant difference between the mean nasolabial angle and columellar show at 1 and 12-months postoperatively, compared with the previous values (p < 0.0001). The nasolabial angles were in a favorable position with an increase of 12 to 15 degrees compared with the preoperative state. The columellar show also improved by an average of 1.2 mm and was in good condition. The postoperative dorsal nasal deviation was significantly reduced, and projection was significantly increased (3.521 ± 0.087 mm vs. 0.719 ± 0.028; p < 0.0001; p < 0.001). Moreover, this method had a significant favorable effect on nasal obstruction (p = 0.049).
Conclusion Our results showed that septorhinoplasty using SBEG is useful for correcting caudal septal deviation, with favorable surgical outcomes, and it has responded well to all five aforementioned criteria.
Constant current pulsed power supply for long pulse arc discharge positive hydrogen ion source
Authors: Motwani Kapil , Ghodke Dharmraj V. , Amban Ajith , Kochunarayanan Murali Krishnan , Ansari M. S. , Prasad Vijendra 
Published: October 2023

The simplest way to produce high density hydrogen plasmas is to form an arc between the arcing electrode and the plasma chamber (cathode). For arc-based hydrogen plasma generation, a pulsed power supply that delivers 2 ms-long constant current pulse has been developed. This pulsed power supply employs a high frequency buck converter topology with a nonlinear filter inductor. This paper describes the development and testing of a constant current pulsed power supply that operates at 50 A and 550 V with a pulse width of 2 ms and a pulse repetition rate of 2 Hz. By changing the arc current, the arc impedance and the positive hydrogen ion current were also measured. The extraction of positive hydrogen ions was carried out using a three-electrode extraction design, which results in a current of 80 mA of positive hydrogen ions at an energy of 50 keV.