bluuebunny/crossref_metadata_2025_split huggingface dataset:
The role of healthcare leaders in implementing equitable clinical academic pathways for nurses: An integrative review
Authors: Aspinall Cathleen , Slark Julia , Parr Jenny , Pene Bobbie‐Jo , Gott Merryn 
Published: January 2024

AbstractAimTo identify and synthesize empirical evidence on the role of healthcare leaders in the development of equitable clinical academic pathways for nurses.DesignIntegrative literature review.Data SourcesLiterature was searched using CINAHL, PubMed, ProQuest and Google Scholar databases.Review MethodsA total of 114 eligible articles published between 2010 and2022 were screened, 16 papers were selected.ResultsResults highlighted the need for consistent national, regional, and organizational policy approaches to developing clinical academic careers for nurses. Government health departments and National Health boards must focus on increasing engagement in research and evidence‐based nursing practice for high‐quality patient care. Discriminatory practices and attitudes were identified as barriers. Discrimination due to gender was evident, while the impact of race, ethnicity, and other social categories of identity are under‐researched. Educational leaders must unravel misconceptions about research, highlighting its relevance to patient care and bedside nurses' work. Academic leaders together with executive nurses, research funders and professional nursing bodies must create appropriately remunerated career structures. Transformative approaches are required to develop the clinical academic nurse role and understand its value in clinical practice.ConclusionMultiple elements exist within complex systems that healthcare leaders can navigate collaboratively to develop and implement clinical nurse academic roles. This requires vision, acknowledgement of the value of nursing research and the importance of evidence‐based research infrastructures.ImpactFindings highlight the collaborative role of healthcare leaders as critical to the success of critical academic careers for nurses. This review can inform those still to formalize this innovative role for nurses.Reporting MethodThe review complies with the PRISMA guidelines for reporting systematic reviews. This paper contributes evidence about the healthcare leader's role in developing clinical academic pathways for nurses to the wider global clinical community.Patient or Public ContributionNo patient or public contribution was included in this review.
Self‐supporting wound care mobile applications for nurses: A scoping review
Authors: Gagnon Julie , Probst Sebastian , Chartrand Julie , Reynolds Emily , Lalonde Michelle 
Published: January 2024

AbstractAimThis study provides an overview of the literature to identify and map the types of available evidence on self‐supporting mobile applications used by nurses in wound care regarding their development, evaluation and outcomes for patients, nurses and the healthcare system.DesignScoping review.Review MethodJoanna Briggs Institute scoping review methodology was used.Data SourcesA search was performed using MEDLINE, Embase, CINAHL (via EBSCO), Web of Science, LiSSa (Littérature Scientifique en Santé), Cochrane Wounds, Érudit and grey literature, between April and October 2022, updated in April 2023, to identify literature published in English and French.ResultsEleven studies from 14 publications met the inclusion criteria. Mostly descriptive, the included studies presented mobile applications that nurses used, among other things, to assess wounds and support clinical decision‐making. The results described how nurses were iteratively involved in the process of developing and evaluating mobile applications using various methods such as pilot tests. The three outcomes most frequently reported by nurses were as follows: facilitating care, documentation on file and access to evidence‐based data.ConclusionThe potential of mobile applications in wound care is within reach. Nurses are an indispensable player in the successful development of these tools.Implications for the Profession and Patient CareIf properly developed and evaluated, mobile applications for wound care could enhance nursing practices and improve patient care. The development of ethical digital competence must be ensured during initial training and continued throughout the professional journey.ImpactWe identified a dearth of studies investigating applications that work without Internet access. More research is needed on the development of mobile applications in wound care and their possible impact on nursing practice in rural areas and the next generation of nurses.Reporting MethodThe Preferred Reporting Items for Systematic Reviews and Meta‐analysis Extension for Scoping Review guidelines were used.Patient or Public ContributionNo patient or public contribution.
Nutritional status of the older adults in nursing homes: A cross‐sectional study
Authors: Chen Qiu , Shen Jun , Gao Ying , Wang Xin Xia , Jia Qian Ying , Li Miao 
Published: January 2024

AbstractAim and objectivesTo investigate the nutritional status of older adults in nursing homes in Chongqing, China, compare and analyse the differences in the physical condition, cognitive function and social‐related factors of older adults with different nutritional statuses.BackgroundMalnurtition in the older people has become a priority concer, and the incidence and factors associated with malnutrition vary somewhat by healthcare setting. In Chongqing ,China, there is lack of research on malnutrition of the older people in nursing homes. Here, we investigated the incidence of malnutrition and analysed the associated factors.DesignA cross‐sectional study.MethodsFrom January to April 2023, a cross‐sectional survey was conducted in three nursing homes in Chongqing, China. Participants completed a series of questionnaires, including the Demographic Information Questionnaire which included age, gender, education level, previous occupation, marital status and other information. The survey also included validated non‐demographic instruments [Short‐Form Mini‐Nutritional Assessment (MNA‐SF), Barthel Index (BI) and Mini‐mental State Examination (MMSE)] to identify related impact factors. The Guidelines for cross‐sectional studies were used in this study (Data S1).Results209 older adults aged 60 and over participated in this study, of whom 121 were women and 88 were men. The average (SD) age of the participants was 84.7 (6.3) years. Of the participants, 46.4% were classified as well nourished. About 39.2% were at risk of malnutrition and 14.4% were malnourished. Compared to those who were well nourished, those who were malnourished or at risk of becoming malnourished were more likely to suffer from comorbidities, polypharmacy, a higher risk of falling, ADL dependence and to receive more nutritional interventions. However, there are no significant differences after adjustment for age, education level, previous occupation, marital status, length of stay, and type of health care payment.ConclusionMalnutrition is a common problem among older adults innursing homes in Chongqing, China. There are certain differences in physical conditions and nutritional interventions among older adults withdifferent nutritional status.Public ContributionThis study suggests that the problem of malnutrition is very prominent in nursing homes in Chongqing, China. Cognitive impairment, impaired activities of daily living, fall risk and nutritional intervention need to be prevalent in older adults with (risk of) malnutrition.
Effectiveness of the lay health advisor program on oral function and quality of life in aboriginal older adults: A randomized controlled trial
Authors: Cheng Bo‐Han , Ho Pei‐Shan , Hsu Chih‐Cheng , Chen Fu‐Li , Chen Ming‐An , Kabasawa Yuji , Huang Hsiao‐Ling 
Published: January 2024

AbstractBackgroundAboriginal older adults residing in remote areas have poor oral function due to inadequate access to healthcare services. Lay health advisor (LHA) strategies can fill capacity shortages of healthcare professionals in rural communities and increase population acceptance of health care or healthy behaviours.Objective(s)To evaluate the effectiveness the LHA program on oral function and oral health–related quality of life (OHRQoL) among older adults in aboriginal community.MethodsParticipants were randomly assigned to an experimental group (EG; n = 122) and a control group (CG; n = 118). All participants performed oral exercises, and the EG received additional one‐on‐one 30‐min lessons by an LHA over 4 weeks. Data were collected through face‐to‐face interview and oral examination. The generalized estimating equation model was used to analyse changes in outcomes over time.ResultsThe EG exhibited significantly greater improvement in swallowing (β = .63) at the 6‐month follow‐up and in masticatory performance (β = .52) and pronunciation of the syllable/pa/ (β = 2.65) at the 2‐week follow‐up than the CG did. The EG had a significantly lower plaque control record (β = −.14) and plaque index (β = −.30) at the 3‐month follow‐up than the CG did. Moreover, the OHRQoL was significantly increased at 6‐months follow‐up in the EG (p = .010).ConclusionThe LHA program had positive effects on chewing, swallowing and plaque control in aboriginal older adults. LHA group also experienced positive long‐term effect on OHRQoL after intervention.
Effectiveness of novel oral hygiene instruction avoiding inattentional blindness using an application for unique plaque control record calculation: A randomized clinical trial
Authors: Mitani Akio , Matsuura Takato , Aino Makoto , Hayashi Jun‐ichiro , Nishida Eisaku , Hori Miki , Kikuchi Takeshi 
Published: January 2024

AbstractObjectiveThis study was performed to estimate the effectiveness of novel oral hygiene instruction (OHI) focusing on areas with deep periodontal pockets for reduction of periodontal inflammation.Background Data Discussing the Present Status of the FieldBecause stained areas on the plaque chart do not always correspond to the areas with deep periodontal pockets, conventional OHI based on O'Leary's plaque control record (PCR) often provides guidance inconsistent with the target area.MethodsThis randomized clinical trial involved two groups: (1) OHI based on the PCR limited in deep pocket sites (novel OHI group) and (2) OHI based on O'Leary's PCR (conventional OHI group). The unique PCR (aggressive target for PCR [agPCR]; only counting the plaque‐stained areas with PD at ≥4 mm sites) for the novel OHI was calculate by dedicated expression program. The probing depth (PD), bleeding on probing (BOP), and periodontal inflamed surface area (PISA) were obtained at the baseline and 5 to 6 months later.ResultsThe approximation curve with PISA before and after instruction indicated that the PISA converged to a lower value after instruction in the novel OHI group. The approximation curve with the improvement rate of the PISA and agPCR showed a positive correlation in the novel OHI group but no correlation in the conventional OHI group.ConclusionControl of inflammation was more effective in the novel OHI group. These results suggest that this novel OHI technique using our developed application could be used as a strategy to improve the effectiveness of brushing instruction.
Non‐routine tasks and ICT tools in telework
Authors: Okubo Toshihiro 
Published: January 2024

AbstractTelework has spread during the pandemic of coronavirus disease (COVID‐19). Using a unique individual‐level survey in Japan, we investigate how telework has changed the way people live and work and what impediments hamper telework use. As a result, we find that telework allows workers to spend more time on leisure and their families. Compared with routine task workers, non‐routine (abstract) task workers are more suited to telework. However, once engaged in telework, non‐routine task workers have fewer opportunities to communicate with coworkers, which is a serious impediment that tends to hamper work performance and compromise mental health.
Reduction rate of anti‐acetylcholine receptor antibody titer levels is an early prognostic indicator for myasthenia gravis
Authors: Hamada Yasuhiro , Deguchi Kazushi , Takaba Keita , Kawakita Rie , Takata Tadayuki , Morishita Asahiro , Kobara Hideki , Masaki Tsutomu 
Published: January 2024

AbstractBackgroundA realistic treatment goal for myasthenia gravis (MG) is achieving minimal manifestations or better status with prednisolone at ≤5 mg/day (MM‐or‐better‐5 mg), considering a patient's health‐related quality of life. Prognosis prediction during the early phases of immunotherapies might be critical for determining subsequent treatment strategies; however, the appropriate biomarkers remain unknown.AimThis study aimed to clarify whether the reduction rate of anti‐acetylcholine receptor antibody (RR‐AChR Ab) titer levels is a useful biomarker for predicting MM‐or‐better‐5 mg achievement.MethodsWe retrospectively investigated patients with MG and AChR Abs who received immunotherapy for the first time. The RR‐AChR Ab titer levels were calculated in the early (within 30 days), middle (31–60 days), and late (61–100 days) periods after starting immunotherapies. A receiver operating characteristic (ROC) curve was generated to determine an appropriate cutoff value for RR‐AChR Abs to achieve an MM‐or‐better‐5 mg.ResultsOf 53 patients, 24 (45%) achieved MM‐or‐better‐5 mg after 1 year. For the early period, the RR‐AChR Ab cutoff value to predict MM‐or‐better‐5 mg was 1.68%/day with an area under the curve (AUC) of 0.75 (sensitivity, 85%; specificity, 70%). However, the middle and late posttreatment AUC values did not predict MM‐or‐better‐5 mg achievement.ConclusionThe RR‐AChR Ab might be an appropriate prognostic biomarker during the early period of MM‐or‐better‐5 mg achievement. In the era of early fast‐acting treatment strategies, the RR‐AChR Ab trend after starting immunotherapies may guide the subsequent treatment choices.
Lily LlHSFC2 coordinates with HSFAs to balance heat stress response and improve thermotolerance
Authors: Wu Ze , Li Ting , Ding Liping , Wang Chengpeng , Teng Renda , Xu Sujuan , Cao Xing , Teng Nianjun 
Published: January 2024

Summary

Heat stress transcription factors (HSFs) are core regulators of plant heat stress response. Much research has focused on class A and B HSFs, leaving those of class C relatively understudied.

Here, we reported a lily (Lilium longiflorum) heat‐inducible HSFC2 homology involved in thermotolerance. LlHSFC2 was located in the nucleus and cytoplasm and exhibited a repression ability by binding heat stress element. Overexpression of LlHSFC2 in Arabidopsis, tobacco (Nicotiana benthamiana), and lily, all increased the thermotolerance. Conversely, silencing of LlHSFC2 in lily reduced its thermotolerance.

LlHSFC2 could interact with itself, or interact with LlHSFA1, LlHSFA2, LlHSFA3A, and LlHSFA3B of lily, AtHSFA1e and AtHSFA2 of Arabidopsis, and NbHSFA2 of tobacco. LlHSFC2 interacted with HSFAs to accelerate their transactivation ability and act as a transcriptional coactivator. Notably, compared with the separate LlHSFA3A overexpression, co‐overexpression of LlHSFC2/LlHSFA3A further enhanced thermotolerance of transgenic plants. In addition, after suffering HS, the homologous interaction of LlHSFC2 was repressed, but its heterologous interaction with the heat‐inducible HSFAs was promoted, enabling it to exert its co‐activation effect for thermotolerance establishment and maintenance.

Taken together, we identified that LlHSFC2 plays an active role in the general balance and maintenance of heat stress response by cooperating with HSFAs, and provided an important candidate for the enhanced thermotolerance breeding of crops and horticulture plants.
The m6A reader YTHDC2 regulates UVB‐induced DNA damage repair and histone modification
Authors: Yang Zizhao , Verghese Michelle , Yang Seungwon , Shah Palak , He Yu‐Ying 
Published: January 2024

AbstractUltraviolet B (UVB) radiation represents a major carcinogen for the development of all skin cancer types. Mechanistically, UVB induces damage to DNA in the form of lesions, including cyclobutane pyrimidine dimers (CPDs). Disruption of the functional repair processes, such as nucleotide excision repair (NER), allows persistence of DNA damage and contributes to skin carcinogenesis. Recent work has implicated m6A RNA methylation and its regulatory proteins as having critical roles in facilitating UVB‐induced DNA damage repair. However, the biological functions of the m6A reader YTHDC2 are unknown in this context. Here, we show that YTHDC2 inhibition enhances the repair of UVB‐induced DNA damage. We discovered that YTHDC2 inhibition increased the expression of PTEN while it decreased the expression of the PRC2 component SUZ12 and the levels of the histone modification H3K27me3. However, none of these functions were causally linked to the improvements in DNA repair, suggesting that the mechanism utilized by YTHDC2 may be unconventional. Moreover, inhibition of the m6A writer METTL14 reversed the effect of YTHDC2 inhibition on DNA repair while inhibition of the m6A eraser FTO mimicked the effect of YTHDC2 inhibition, indicating that YTHDC2 may regulate DNA repair through the m6A pathway. Finally, compared to normal human skin, YTHDC2 expression was upregulated in human cutaneous squamous cell carcinomas (cSCC), suggesting that it may function as a tumor‐promoting factor in skin cancer. Taken together, our findings demonstrate that the m6A reader YTHDC2 plays a role in regulating UVB‐induced DNA damage repair and may serve as a potential biomarker in cSCC.
Trajectory of lung function in diabetic adults: A 16‐year follow‐up study of community‐based prospective cohorts
Authors: Choi Wonsuk , Moon Joon Ho , Choi Hayoung , Lee Hyun , Kim Hee Kyung , Kang Ho‐Cheol , Cho Nam H. 
Published: January 2024

AbstractBackground and ObjectiveTo investigate the difference in lung function according to diabetes status in a community‐based prospective study.MethodsIndividuals aged 40–69 years from two community‐based cohorts were followed prospectively for 16 years. A spirometer was used to evaluate lung function at baseline, and lung function tests were carried out biennially thereafter. Multivariable linear regression analysis was performed for the cross‐sectional and longitudinal analyses based on diabetes status.ResultsAmong the 6483 subjects, 2114 (32.6%) had prediabetes and 671 (10.4%) had diabetes. The prediabetes and diabetes groups had lower baseline % predicted values of forced expiratory volume in 1 s (FEV1) (mean, −1.853; 95% confidence interval [CI] –2.715 to −0.990 for prediabetes and mean, −4.088; 95% CI –5.424 to −2.752 for diabetes) and forced vital capacity (FVC) (mean, −2.087; 95% CI –2.837 to −1.337 for prediabetes and mean, −4.622; 95% CI –5.784 to −3.460 for diabetes) compared to the normoglycemia group after adjusting for relevant covariates. The rate of decline in FEV1% predicted (mean, −0.227; 95% CI –0.366 to −0.089) and FVC % predicted (mean, −0.232; 95% CI –0.347 to −0.117) during follow‐up were faster in the diabetes group than in the normoglycemia group. The diabetes group had a lower proportion of normal ventilation (ptrend = 0.048) and higher proportions of restrictive (ptrend = 0.001) and mixed (ptrend = 0.035) ventilatory disorders at the last follow‐up.ConclusionDiabetes is associated with a lower baseline lung function and a faster rate of deterioration.
The impact of alcohol hand sanitizer use on skin health between healthcare worker: Cross‐sectional study
Authors: Alhalwani Amani , Husain Amal , Saemaldahar Amjad , Makhdoum Faizah , Alhakami Montaha , Ashi Rana , Wali Razaz , Alsharif Sarah , Khan Muhammad Anwar , Jastaniah Nisreen , Fasfous Ismail 
Published: January 2024

AbstractBackground2020 Coronavirus disease 2019 (COVID‐19) has become a global health crisis, so hand alcohol‐based sanitizers have become essential to preventive measures. Previous studies reported that hand sanitizers could kill bacteria and viruses; however, using them excessively can lead to health problems if misused. In light of sanitizer overuse, the availability of various products and qualities in the market, and the absence of data on skin problems, we conducted a survey study about the impact of commonly used sanitizers on skin health, particularly on hands. The study aimed to determine the prevalence and the correlation between hand sanitizer and skin health during the COVID‐19 pandemic at the National Guard Institute‐ Jeddah, Saudi Arabia.MethodsA cross‐sectional study was conducted using a self‐administered online questionnaire by sending an invitation link to students and employees of the National Guard Institute‐ Jeddah, Saudi Arabia, in 2021. A chi‐squared test was used to obtain differences concerning awareness of hand sanitizer use/type and hand skin health.ResultsIn the total 216 participants, there were considerably more skin conditions reported by women (62.5%) and respondents ages 31–40 (36.6%). For the types of hand sanitizers, 89.8%, 40.9%, 30.2%, 4.7%, and 6% were recorded: gel, spray, wipes, foam, and others, respectively, and the survey applicants were filled by 60.6% of non‐medical workers. According to the survey, 32.9% of participants experienced a hand crack, which was the most common hand side effect. The handwashing frequency was reported between 3 to 7 times per day during the COVID‐19 pandemic, and 9.3% of participants used hand sanitizers more than 10 times daily.ConclusionIt was found that during the pandemic, skin changes were common among the NGHA population and healthcare workers. Consequently, the adverse health effects of these hand sanitizers on human health may result in multiple infections and toxicity. The present study provides appropriate knowledge on the types and ingredients of hand sanitizers as essential factors for skin health, preventing health risks during this pandemic.
Dendrobium polysaccharide (DOP) ameliorates the LL‐37‐induced rosacea by inhibiting NF‐κB activation in a mouse model
Authors: Zeng Bijun , Yang Zhibo , Jiang Gufen , Zhou Hongxia , Zhang Yujin , Wang Chang , Peng Youhua , Yan Yining , Chen Zi 
Published: January 2024

AbstractBackgroundRosacea, a common chronic inflammatory skin disease worldwide, is currently incurable with complex pathogenesis. Dendrobium polysaccharide (DOP) may exert therapeutic effects on rosacea via acting on the NF‐κB‐related inflammatory and oxidative processes.Materials and methodsIn this study, an LL‐37‐induced rosacea‐like mouse model was established. HE staining was used to assess the skin lesions, erythema severity scores, pathological symptoms, and inflammatory cell numbers of mice in each group. The inflammation level was quantitatively analyzed using enzyme‐linked immunosorbent assay (ELISA) and reverse transcription‐quantitative real‐time polymerase chain reaction (RT‐qPCR). The expression levels of TLR4 and p‐NF‐κB were finally detected.ResultsDOP improved skin pathological symptoms of rosacea mice. DOP also alleviated the inflammation of rosacea mice. Moreover, the TLR4/NF‐κB pathway was observed to be inhibited in the skin of mice after DOP application. These findings evidenced the anti‐inflammatory effects of DOP on the LL‐37‐induced rosacea mouse model. DOP could inhibit NF‐κB activation, suppress neutrophil infiltration, and reduce pro‐inflammatory cytokines production, which may be the reason for DOP protecting against rosacea.ConclusionThis study may propose an active candidate with great potential for rosacea drug development and lay a solid experimental foundation for promoting DOP application in rosacea therapy.