bluuebunny/crossref_metadata_2025_split huggingface dataset:
Current status of carbon monoxide dehydrogenases (CODH) and their potential for electrochemical applications
Authors: Bährle Rebecca , Böhnke Stefanie , Englhard Jonas , Bachmann Julien , Perner Mirjam 
Published: November 2023

AbstractAnthropogenic carbon dioxide (CO2) levels are rising to alarming concentrations in earth’s atmosphere, causing adverse effects and global climate changes. In the last century, innovative research on CO2 reduction using chemical, photochemical, electrochemical and enzymatic approaches has been addressed. In particular, natural CO2 conversion serves as a model for many processes and extensive studies on microbes and enzymes regarding redox reactions involving CO2 have already been conducted. In this review we focus on the enzymatic conversion of CO2 to carbon monoxide (CO) as the chemical conversion downstream of CO production render CO particularly attractive as a key intermediate. We briefly discuss the different currently known natural autotrophic CO2 fixation pathways, focusing on the reversible reaction of CO2, two electrons and protons to CO and water, catalyzed by carbon monoxide dehydrogenases (CODHs). We then move on to classify the different type of CODHs, involved catalyzed chemical reactions and coupled metabolisms. Finally, we discuss applications of CODH enzymes in photochemical and electrochemical cells to harness CO2 from the environment transforming it into commodity chemicals.
The impact of COVID-19 on PRO development, collection and implementation: views of UK and Ireland professionals
Authors: Holch Patricia , Turner Grace , Keetharuth Anju D , Gibbons E , Cocks Kim , Absolom Kate L 
Published: November 2023

Abstract
Background
PROs are valuable tools in clinical care to capture patients’ perspectives of their health, symptoms and quality of life. However the COVID-19 pandemic has had profound impacts on all aspects of life, in particular healthcare and research. This study explores the views of UK and Irish health professionals, third sector and pharmaceutical industry representatives and academic researchers on the impact of COVID-19 on PRO collection, use and development in clinical practice.

Methods
A volunteer sample took part in a 10 question cross sectional qualitative survey, on the impact of COVID-19, administered online via Qualtrics. Demographic data was descriptively analysed, and the qualitative free text response data was subject to thematic analysis and summarised within the Strengths, Weaknesses, Opportunities and Threats (SWOT) framework.

Results
Forty nine participants took part located in a range of UK settings and professions. Participants highlighted staff strengths during the pandemic including colleagues’ flexibility and ability to work collaboratively and the adoption of novel communication tools. Weaknesses were a lack of staff capacity to continue or start PRO projects and insufficient digital infrastructure to continue studies online. Opportunities included the added interest in PROs as useful outcomes, the value of electronic PROs for staff and patients particularly in relation to integration into systems and the electronic patient records. However, these opportunities came with an understanding that digital exclusion may be an issue for patient groups. Threats identified included that the majority of PRO research was stopped or delayed and funding streams were cut.

Conclusions
Although most PRO research was on hold during the pandemic, the consensus from participants was that PROs as meaningful outcomes were valued more than ever. From the opportunities afforded by the pandemic the development of electronic PROs and their integration into electronic patient record systems and clinical practice could be a lasting legacy from the COVID-19 pandemic.
The day after intracerebral hemorrhage: platelet mass index as predictor of survival—a retrospective cohort study
Authors: Avramidou Despoina , Goulimari Rengina , Stergiou Anastasios , Papadopoulos Vasileios 
Published: November 2023

Abstract
Background
Platelets are implicated in the pathophysiology of intracerebral hemorrhage (ICH). Platelet count (PLT) is affected by platelet loss, while mean platelet volume (MPV) by platelet replenishment. Whether platelet mass index (PMI), the product of PLT and MPV, might predict survival after ICH, remains unknown.

Methods
All first-ever ICH patients, admitted to Xanthi General Hospital between January 2018 and May 2020 and met eligibility criteria, were enrolled in this retrospective cohort study. Demographics, medical record, first-symptom-to-admission time, vital signs, modified Rankin Scale, ICH score, arterial blood gas test, complete blood count, blood biochemistry, and CT scan test were collected for each patient. PMI values on day 1 (admission; PMI1), day 2 (PMI2), and day 7 (PMI7), along with PLT, MPV, platelet distribution width (PDW), and platelet large cell ratio (P-LCR), were evaluated as potential predictors of 12-month survival using Repeated Measures General Linear Model. Binary discretization of predictors was based on optimal scaling and evaluated using binary regression.

Results
From 59 patients enrolled (aged 75.7 ± 12.0 years; 31 females), 29 were still alive 12 months after ICH. Age, arterial hypertension, diabetes mellitus, hemoglobin level (Hb), and oxygen saturation (O2Sat) were correlated with 12-month survival. After adjustment for these parameters, PMI1 and PMI2 were independently correlated with 12-month survival (P = 0.048 and P = 0.004, respectively), while PMI7 was not (P = 0.332). PMI2 ≥ 2,400 fL/μL was best to discriminate survivors from non-survivors (age, arterial hypertension, diabetes mellitus, Hb, and O2Sat adjusted OR 0.123 with 95% CI: 0.023–0.694; P = 0.018).

Conclusions
PMI within the first day after admission for ICH might be used as early predictors of survival. Properly designed prospective studies are needed to further evaluate their contribution as such.
Acceleration of sporadic Creutzfeldt–Jakob disease progression by COVID requires evidence from appropriately designed studies
Authors: Finsterer Josef 
Published: November 2023

AbstractThe aim of this letter to the editor is to discuss the influence of SARS-CoV-2 infection on the progression of sporadic Creutzfeldt–Jakob disease (sCJD). A 73-year-old male was diagnosed with sCJD based on the clinical presentation, cerebral MRI, FDG–PET, and elevated 14-3-3 in cerebrospinal fluid. One month earlier he had suffered a slight COVID-19 infection. It was concluded that COVID-19 can lead to accelerated pathogenesis and exaggerated manifestations of sCJD.
Characterization and genomic analysis of a novel E. coli lytic phage with extended lytic activity against S. Enteridis and S. Typhimurium
Authors: Zhong Zhaoxin , Wang Yanyan , Li Huimin , Zhang Hui , Zhou Yan , Wang Ran , Bao Hongduo 
Published: November 2023

AbstractIn order to effectively use of phages as antimicrobial agents for controlling multidrug-resistant E. coli, it is important to understand phage biology. The isolation and research of novel bacteriophages are urgently needed for food safety and animal health. Phage is considered as a novel alternative antibacterial agents and a new way of prevent, control and treat pathogens. In this paper, we isolated and characterized a novel lytic phage from chicken samples, named vB_EscP_vE20 (in brief vE20). We identified vE20 as belonging to the Podoviridae family through morphological and phylogenetic analysis. It had lytic activities against 24 out of 51 different serotypes of clinical E. coli strains, interestingly it also can lyse Salmonella species, such as Salmonella Enteritidis (S. Enteritidis) and Samonella Typhimurium (S. Typhimurium). One step growth curve showed that the latent period and lysis period was 10 min and 60 min, respectively. The burst size of vE20 was about 60 PFU/cell. The phage vE20 survived in a wide range of temperatures (30–60 °C) and pH (3–11). The whole genome size of phage vE20 is 77,938 bps, which is double stranded DNA. There are 121 Open reading frame (ORFs) in total, and the GC-content is 42.17%, without virulence-associated, antibiotic and lysogeny related genes. Phage vE20 has high bactericidal activity in killing E. coli EXG20-1 in cultures containing 4 × 109 cfu/mL in several MOIs culture. The results revealed the promising potential of phage vE20 as attractive candidates for the control of E. coli infections.
Graphical Abstract
Pulmonary tumor embolism secondary to urothelial carcinoma of urinary bladder: case report and literature review
Authors: Bouchaala Abderrahmane , Khalek Ihssane , Kerrouani Oualid , Mouine Najat , Lakhal Zouhair , Benyass Aatif 
Published: November 2023

Abstract
Background
Tumor embolism is the least well-described cause of pulmonary embolism, taking into account the non-specificity of radiographic and nuclear imaging results, the necessity of anatomopathological evidence and the frequency of deep venous thrombosis in the course of solid tumors, suggesting thus thromboembolism.

Case presentation
We report a rare case of urothelial carcinoma of the urinary bladder associated with persistent pulmonary embolism despite being on different anticoagulation regimens, the patient was ultimately found to have tumor thrombus in the pulmonary trunk secondary to tumoral extension. We provide a literature review as well about the diagnosis, evaluation and prognosis and of this rare clinical entity.

Conclusions
Our case highlights the importance of keeping this unusual etiology in mind, particularly when faced with pulmonary embolism occurring in the context of a solid tumor and the ineffectiveness of various anticoagulation protocols. Furthermore, it emphasizes the pivotal role of cytology in confirming diagnosis and guiding therapy.
Delayed appearance of hepatic artery pseudoaneurysm and an arterio-biliary fistula secondary to biliary leakage and bilioma formation in a liver trauma patient and its management through transarterial embolization
Authors: Sahoo Biswajit , Kumar Pankaj , Singh Pradeep Kumar , Sasmal Prakash Kumar , Nayak Manoj Kumar , Mane Krantisurya 
Published: November 2023

Abstract
Background
Pseudoaneurysm and arterio-biliary fistulas are infrequent complications of surgery or iatrogenic trauma, accidental trauma, tumors, vascular malformations, infection, and inflammation of the biliary tract. In a liver trauma patient, they evolve immediately secondary to direct vascular injury and usually present with either drop in hemoglobin level or hemobilia due to bleeding into the peritoneal space or biliary system. In the present case, there were no clinical features of hemobilia or upper gastrointestinal bleeding. Moreover, the hepatic artery pseudoaneurysm and arterio-biliary fistula evolved after a latent period of a few weeks, secondary to the toxic effects of the bile on the vessel walls due to biloma formation or biliary leakage, which is exceptionally uncommon.

Case presentation
This 19-year-old male presented with a severe liver injury complicated by forming a biloma, followed by the development of a pseudoaneurysm and an arterio-biliary fistula. The appropriate hepatic artery branch was successfully embolized using an endovascular approach.

Conclusions
In a liver trauma patient, the latency period for developing a pseudoaneurysm and an arterio-biliary fistula can be from a few days to a few months due to direct vascular injury or toxic effects of the bile on the adjacent vessel walls secondary to bile leakage. Development of hepatic artery pseudoaneurysm and an arterio-biliary fistula after a latent period of a few weeks, secondary to the toxic effects of the bile on the vessel walls due to biloma formation or biliary leakage, is exceptionally uncommon. So, these liver trauma patients require close monitoring and follow-up for early detection and treatment of pseudoaneurysm and arterio-biliary fistula, especially when there are clinical or imaging features of bile leakage or biloma formation. Endovascular treatment of hepatic artery pseudoaneurysm and arterio-biliary fistulas is a safe and effective method.
Control of two-spotted spider mite, Tetranychus urticae, on strawberry by integrating with cyetpyrafen and Phytoseiulus persimilis
Authors: Zhao Shan , Zhao Qiuyu , Dai Xiaoyan , Lv Bing , Wang Ruijuan , Yin Zhenjuan , Zhang Feng , Liu Yan , Su Long , Chen Hao , Zheng Li , Li Hongmei , Xie Lixia , Zhai Yifan 
Published: November 2023

AbstractThe two-spotted spider mite (TSSM, Tetranychus urticae Koch) is a significant agricultural pest, particularly in strawberries. Management of TSSM has traditionally relied on synthetic acaricides, but to mitigate dependency on these chemicals, the control of TSSM on strawberry is often combined with biological control measures and chemical control strategies. The predatory mite, Phytoseiulus persimilis, is a promising biological control agent, preying on all TSSM developmental stages. In this study, we examined the toxicity of six common acaricides on TSSM and P. persimilis, and cyetpyrafen was selected due to its highest relative toxicity value. Then, we examined the compatibility of cyetpyrafen with P. persimilis for TSSM management on strawberries. The results suggested that cyetpyrafen revealed no substantial differences in prey consumption or longevity when compared to the control, though minor effects on the development durations of protonymphs and deutonymphs were noted in the subsequent generation. Additionally, cyetpyrafen's toxicity on key pollinators, such as Apis mellifera and Bombus terrestris, was found to be low. Thus, an integrated strategy combining cyetpyrafen (0.83 mg/L) with P. persimilis (predator–prey ratio of 1:30) was examined under laboratory and field conditions. Laboratory trials demonstrated a reduction in mites per leaf from 32.72 to 14.50 within 3 days, correlating to a 70.23% control efficiency. This efficacy increased to 96.04% by day 9 and was sustained until the experiment concluded on day 27. Field trials similarly showed a reduction in TSSM from 53.93 to 9.63 mites/leaf by day 6, achieving an 83.64% control efficiency, and culminated in a 98.46% reduction by day 10. These findings suggested that an integrated approach utilizing cyetpyrafen in conjunction with P. persimilis can be an effective alternative for TSSM management on strawberry plants.
Assessing Patient Readiness for an Electronic Patient-Reported Outcome–Based Symptom Management Intervention in a Multisite Study
Authors: Paudel Roshan , Tramontano Angela C. , Cronin Christine , Wong Sandra L. , Dizon Don S. , Jenkins Hannah H. , Bian Jessica , Osarogiagbon Raymond U. , Schrag Deborah , Hassett Michael J. 
Published: November 2023

PURPOSE While the use of electronic patient-reported outcomes (ePROs) in routine clinical practice is increasing, barriers to patient engagement limit adoption. Studies have focused on technology access as a key barrier, yet other characteristics may also confound readiness to use ePROs including patients' confidence in using technology and confidence in asking clinicians questions. METHODS To assess readiness to use ePROs, adult patients from six US-based health systems who started a new oncology treatment or underwent a cancer-directed surgery were invited to complete a survey that assessed access to and confidence in the use of technology, ease of asking clinicians questions about health, and symptom management self-efficacy. Multivariable ordinal logistic regression models were fit to assess the association between technology confidence, ease of asking questions, and symptom management self-efficacy. RESULTS We contacted 3,212 individuals, and 1,043 (33%) responded. The median age was 63 years, 68% were female, and 75% reported having access to patient portals. Over 80% had two or more electronic devices. Most patients reported high technology confidence, higher ease of asking clinicians questions, and high symptom management self-efficacy (n = 692; 66%). Patients with high technology confidence also reported higher ease of asking nurses about their health (adjusted odds ratio [AOR], 4.58 [95% CI, 2.36 to 8.87]; P ≤ .001). Those who reported higher ease of asking nurses questions were more likely to report higher confidence in managing symptoms (AOR, 30.54 [95% CI, 12.91 to 72.30]; P ≤ .001). CONCLUSION Patient readiness to use ePROs likely depends on multiple factors, including technology and communication confidence, and symptom management self-efficacy. Future studies should assess interventions to address these factors.
Growth in Suicide Rates Among Children During the Illicit Opioid Crisis
Authors: Powell David 
Published: November 2023

Abstract
This article documents child suicide rates from 1980 to 2020 in the United States using the National Vital Statistics System Multiple Cause of Death database. After generally declining for decades, suicide rates among children aged 10–17 accelerated from 2011 to 2018 in an unprecedented rise in both duration and magnitude. I consider the role of the illicit opioid crisis in driving this mental health crisis. In August 2010, an abuse-deterrent version of OxyContin was introduced and the original formulation was removed from the market, leading to a shift to illicit opioids and stimulating growth in illicit opioid markets. Areas more exposed to reformulation—as measured by pre-reformulation rates of OxyContin misuse in the National Survey on Drug Use and Health—were more affected by the transition to illicit opioids and experienced sharper growth in child suicide rates. The evidence suggests that children's illicit opioid use did not increase, implying that the illicit opioid crisis engendered higher suicide propensities by increasing suicidal risk factors for children, such as increasing rates of child neglect and altering household living arrangements. In complementary analyses, I document how living conditions declined for children during this time period.
CORONELISMO NO CONTEXTO POLÍTICO DO MUNICÍPIO DE BARRAS-PI (1955 a 1980)
Authors: Silva da Costa Francielcio , Ravenna da Silva Santos Francisca 
Published: November 2023

O presente artigo intitula-se Coronelismo no contexto político do município de Barras - PI (1955 a 1980), logo este trabalho acadêmico, abordou questões complexas ligadas a política, ao coronelismo e a História local da cidade de Barras Piauí. Além disso, esse estudo se desenvolveu principalmente para compreender como o sistema político coronelista, influenciou na política barrense entre os anos de 1955 a 1980. Posto isso, os objetivos desta pesquisa são: analisar qual a interferência que os coronéis exerciam sobre os seus eleitores em Barras PI, investigar quais as atitudes adotadas pelos eleitores diante do controle exercido pelos coronéis, bem como verificar os comportamentos dos políticos barrenses diante do favoritismo e por fim refletir acerca das conseqüências do coronelismo no município de Barras - PI. Metodologicamente falando, este artigo foi construído mediante um levantamento bibliográfico, e como instrumental de pesquisa foi utilizado o questionário com perguntas abertas aplicadas respectivamente ao vereador da Câmara Municipal de Barras, a Presidente do Sindicato dos Trabalhadores Rurais de Barras e alguns moradores barrenses que vivenciaram o coronelismo no Município. Nesta perspectiva, ressalta-se que os referenciais teóricos desta pesquisa, foram baseados em autores, como Leal (1975), Hobbes (1979) e Faoro (1997). Por fim, conclui-se que o coronelismo é um tema complexo, importante e atual do ponto de vista, historiográfico.

Palavras-Chave: Coronelismo. Política. Oligarquias. Barras PI.
Expressed emotion in the South Asian diaspora living in the UK: A qualitative study
Authors: Sharif Hira Salman , Miah Syed K. , Ramanathan Amrita , Glover Naomi , Shaikh Madiha 
Published: November 2023

Background
‘Expressed Emotion (EE)’ captures ways in which emotions are expressed within a family environment. Research has found that EE in families has an impact on psychiatric illness, in particular psychosis, such that it increases risk of relapse. EE was conceptualised by research conducted in the UK. Thus, behaviours defined as pathological were largely based on white samples adhering to UK norms. Cross-cultural variations have been found in EE and its relationship with clinical outcomes. A more culturally appropriate understanding of norms surrounding the EE across cultures is required.

Aims
This study aims to use a bottom-up approach to provide a culturally specific understanding of family relationships and EE across ‘non-clinical’ UK-based South Asian families.

Methods
Semi-structured interviews were conducted with 18 South Asian participants to explore their relationships with a significant other. Interviews were analysed using thematic analysis.

Results
Four main themes were generated: expression of love, setting boundaries, inter-generational differences and acceptance.

Conclusion
The findings indicate considerable cultural variability within EE and highlight the need to interpret EE in the context of socio-cultural norms. Whilst certain domains of EE that are considered pathological in Western contexts are present in the UK-based South Asian diaspora, these are perceived as less problematic, indicative of varying cultural norms.
Improvement of violence management among nurses in Iran: The best practice implementation project in a health promoting hospital
Authors: Abedi Ghasem , Haghgoshayie Elaheh , Hasanpoor Edris , Etemadi Jalil , Nazari Morteza , Vejdani Razieh 
Published: November 2023

Background
This project aimed to assess compliance with evidence-based criteria’ for the prevention and management of workplace violence against nursing staff in Shahid-Beheshti hospital, Maragheh, Iran. Workplace violence is a managerial and workplace occupational health and safety issue that can affect the performance of an institution. Further, it might turn the work environment into an insecure and hostile one which can influence the performance of employees and their professional relationships negatively. Nevertheless, staff have their own legal rights, and their organizations are legally and ethically in charge of providing them with safe work environments.

Methods
Following the JBI Practical Application of Clinical Evidence System and Getting Research into Practice audit and feedback tool with three phases of activities, this project utilized an implementation framework incorporating quality improvement. Furthermore, the audit tool was used to establish the project and set up the measurement and evaluation of three evidence-based criteria.

Results
The post-implementation audit results indicated a significant improvement in violence management and prevention. The compliance rate on the first criterion, i.e. aggression management training, increased from 49% at baseline to 81% at the end. The second criterion, i.e. timely support and assistance following an incident, exhibited greater increase from eight to 73%. Finally, an increased compliance was noted on the third criterion, i.e. policy for risk management and safe environment, from 22 to 77%.

Conclusions
The current project successfully implements evidence-based violence management in Shahid-Beheshti hospital. It reveals significant results on compliance and the increasing knowledge of nurses on evidence-based stress management, communication skills and self-companion.