bluuebunny/crossref_metadata_2025_split huggingface dataset:
Relationship between functional structures and horizontal connections in macaque inferior temporal cortex
Authors: Hu Danling , Sato Takayuki , Rockland Kathleen S. , Tanifuji Manabu , Tanigawa Hisashi 
Published: January 2025

Abstract
Horizontal connections in anterior inferior temporal cortex (ITC) are thought to play an important role in object recognition by integrating information across spatially separated functional columns, but their functional organization remains unclear. Using a combination of optical imaging, electrophysiological recording, and anatomical tracing, we investigated the relationship between stimulus-response maps and patterns of horizontal axon terminals in the macaque ITC. In contrast to the “like-to-like” connectivity observed in the early visual cortex, we found that horizontal axons in ITC do not preferentially connect sites with similar object selectivity. While some axon terminal patches shared responsiveness to specific visual features with the injection site, many connected to regions with different selectivity. Our results suggest that horizontal connections in anterior ITC exhibit diverse functional connectivity, potentially supporting flexible integration of visual information for advanced object recognition processes.
A bioinformatic approach to characterize the vitellogenin receptor and the low density lipoprotein receptor superfamily in the newt Cynops orientalis
Authors: Spinsante Chiara , Carducci Federica , Carotti Elisa , Canapa Adriana , Bizzaro Davide , Biscotti Maria Assunta , Barucca Marco 
Published: January 2025

Abstract
The Low Density Lipoprotein receptors (LDLRs) gene family includes 15 receptors: very low-density lipoprotein receptor (VLDLR), LDLR, Sorting-related receptor with A-type repeats (SORLA), and 12 LDL receptor-related proteins (LRPs): LRP1, LRP1B, LRP2, LRP3, LRP4, LRP5, LRP6, LRP8, LRP10, LRP11, LRP12, LRP13. Most of these are involved in the transduction of key signals during embryonic development and in the regulation of cholesterol homeostasis. In oviparous animals, the VLDL receptor is also known as VTGR since it facilitates the uptake of vitellogenin in ovary. In tetrapods, information concerning genes encoding these proteins is limited to a few taxa. Here, we report the characterization of VTGR in the amphibian Cynops orientalis. The secondary structure analyses and the expression profiles obtained from hepatic and gonadal tissues of C. orientalis supported the role of VTGR as vitellogenin oocyte membrane receptor in this species. Moreover, to get a holistic view of the evolutionary history of this gene superfamily, we extended our investigation to all 15 genes belonging to the LDLR superfamily analyzing through a phylogenetic analysis a total of 161 sequences belonging to 11 genera of vertebrates. The position of LRP8 in the tree and its expression findings in C. orientalis ovary allowed us to suggest that other proteins of the LDLR superfamily could act as receptors during vitellogenesis.
Optimized design and experimental analysis of the vertical mixing plow for enhancing planosol improvement machine
Authors: Du Jiaxing , Hou Jiyao , Dun Yuanyuan , Yang Chuanhua , Li Xiaohai , Zhu Baoguo , Cai Lijun , Dun Guoqiang 
Published: January 2025

Abstract
Improved soil fertility to sustain crop productivity is important to enhance agroecosystem services. To address the low nutrient content, subsoil compaction, and poor root penetration in Planosol, a new machine was designed to improve these conditions. This machine integrates subsoil mixing and fertilizer application. The paper details the machine’s structure and working principle, focusing on optimizing the vertical mixing plow. Furthermore, discrete element method simulations were conducted, using tillage depth, forward speed, and plow height as factors, with soil mixing rate and tractive resistance serving as the evaluation indicators. Results showed optimal performance at 553 mm tillage depth, 1 m/s speed, and 227 mm plow height, with tractive resistance of 7460.5 N and a soil mixing rate of 72.1%. Field trials and soil improvement tests based on optimized parameters confirmed the accuracy and reliability of the simulation results. Compared to the Shallow plowing and subsoiling area, the subsoil mixing improvement area showed significant improvement, with a yield increase of 16.4–18.9% over two years.
Tilting deformation analysis and instability prediction of arch-locked-segment landslides induced by rainfall
Authors: Liu Jingjing , Liu Handong , Luo Jiaming , Chen Jiaxing , Wang Hu 
Published: January 2025

Abstract
The failure of locked-segment landslides is associated with the destruction of locked segments that exhibit an energy accumulation effect. Thus, understanding their failure mode and instability mechanism for landslide hazard prevention and control is critical. In this paper, multiple instruments, such as tilt sensors, pore water pressure gauges, moisture sensors, matrix suction sensors, resistance strain gauges, miniature earth pressure sensors, a three-dimensional (3D) laser scanner, and a camera, were used to conduct the physical model tests on the rainfall-induced arch locked-segment landslide to analyze the resulting tilting deformation and evolution mechanism. The results indicate that the tilting deformation characteristics in the locked segment are consistent with the variation in its strain, stress, hydrodynamic responses, and slope morphology, suggesting that tilting deformation can serve as a novel monitoring approach for landslide instability. Further, the tangent angle method and the tilting rate reciprocal method can be utilized to predict the landslide instability based on the landslide tilting deformation curve. The effectiveness of this method is validated in the Huangzangsi dam area, which provides theoretical foundations for understanding the catastrophic mechanism and instability prediction of arch-locked-segment landslides.
Derivative of clove oil used as a chemosensor for the colorimetric and fluorometric detection of Al3+: crystal structure description and live cell imaging
Authors: Khatun Mohafuza , Mandal Jayanta , Ganguly Rajdeep , Barui Ananya , Banerjee Snehasis , Saha Amrita 
Published: January 2025

A derivative of clove oil was synthesized (H3L) for fluorometric and colorimetric detection of Al3+ ions. Strong association constant and low limit of detection of H3L against Al3+ enable its use in real-world applications and cell imaging studies.
DC‐link voltage stability enhancement in intermittent microgrids using coordinated reserve energy management strategy
Authors: Imtiaz Saqif , Yang Lijun , Munir Hafiz Mudassir , Memon Zulfiqar Ali , Kilic Heybet , Naz Muhammad Naveed 
Published: January 2025

AbstractIn recent years, due to its cost effectiveness and environmental advantages, demand for renewable energy resources has grown and their contributions to grid power has therefore increased while requiring effective frequency and voltage regulation. DC link voltage instability is a potential problem in solar energy microgrids, especially during an intermittency, where the system reliability degrades and DC link capacitor is under higher stress. In this article, a novel reserve energy management scheme based on battery and super capacitor storage is presented to stabilize the DC link voltage and reduce capacitor stress, while enhancing the system reliability. The scheme is tested in four different scenarios: Inverter connected DC‐microgrid with irradiance intermittencies, standalone DC‐microgrid without inverter and irradiance intermittencies, standalone DC‐microgrid without inverter and load intermittencies, and standalone DC‐microgrid with inverter under irradiance intermittencies. Simulation results indicate that the proposed control strategy stabilizes DC link voltage over all scenarios, even subject to large instances of irradiance or load changes. During low solar irradiance, the battery and super‐capacitor promote voltage stability by compensating power deficits from the utility grid in the inverter connected grid case. In stand alone mode, the battery provides power during intermittencies and the supercapacitor provides fast transient voltage compensation. The strategy is notable in reducing stress on DClink capacitors and mitigating inverter voltage fluctuations, ultimately enhancing inverter longevity. The results show that the proposed control scheme can improve voltage stability, mitigate the transient effects and guarantee the reliable operation of solar microgrids in variable conditions.
Background exoplanet candidates in the original Kepler field
Authors: Bienias J. , Szabó R. 
Published: January 2025

Context. During the primary Kepler mission, between 2009 and 2013, about 150 000 pre-selected targets were observed with a 29.42 minute-long cadence. However, a survey of background stars that fall within the field of view of the downloaded apertures of the primary targets has revealed a number of interesting objects. In previous papers we have presented surveys of short-period eclipsing binaries and RR Lyrae stars.
Aims. The current survey of the Kepler background is concentrated on identifying longer-period eclipsing binaries and pulsating stars. These will be the subject of later papers. In the course of this survey, in addition to eclipsing binaries and pulsating stars, seven exoplanet candidates have been uncovered and in this paper we report on these candidates.
Methods. We used Lomb-Scargle, light curve transit search, and phase dispersion minimisation methods to reveal pixels that show significant periodicities, resulting in the identification of the seven exoplanet candidates. We prepared the light curves for analysis using Pytransit software and cross-matched the pixel coordinates with Gaia and other catalogues to identify the sources.
Results. We identify seven hot Jupiter exoplanet candidates with planet radii ranging from 0.8878 to 1.5174 RJup and periods ranging from 2.5089 to 4.7918 days.
Redistribution of ices between grain populations in protostellar envelopes
Authors: Kalvāns Juris 
Published: January 2025

Context. Matter that falls onto a protoplanetary disk (PPD) from a protostellar envelope is heated before it cools again. This induces sublimation and subsequent re-adsorption of ices that accumulated during the prestellar phase.
Aims. We explore the fate of ices on multiple-sized dust grains in a parcel of infalling matter.
Methods. A comprehensive kinetic chemical model using five grain-size bins with different temperatures was applied for an infalling parcel. The parcel was heated to 150 K and then cooled over a total timescale of 20 kyr. Effects on ice loss and re-accumulation by the changed gas density, the maximum temperature, the irradiation intensity, the size-dependent grain temperature trend, and the distribution of the ice mass among the grain-size bins were investigated.
Results. A massive selective redistribution of ices exclusively onto the surface of the coldest grain-size bin occurs in all models. The redistribution starts already during the heating stage, where ices that are sublimated from warmer grains re-adsorb onto colder grains before complete sublimation. During the cooling stage, the sublimated molecules re-freeze again onto the coldest grains. In the case of full sublimation, this re-adsorption is delayed and occurs at lower temperatures because a bare grain surface has lower molecular desorption energies in our model.
Conclusions. Most protostellar envelope grains enter the PPD ice poor (bare). Ices are carried by a single coldest grain-size bin, here representing 12% of the total grain surface area. This bare ice-grain dualism can affect the rate of the grain coagulation. The ice components are stratified on the grains according to their sublimation temperatures.
The Diagnostic Assessment of Platelet Function Defects - Part 2: Update on Platelet Disorders
Authors: Althaus Karina , Hoepner Gero , Zieger Barbara , Prüller Florian , Pavlova Anna , Boeckelmann Doris , Birschmann Ingvild , Müller Jens , Rühl Heiko , Sachs Ulrich , Kehrel Beate , Streif Werner , Bugert Peter , Zaninetti Carlo , Cooper Nina , Schulze Harald , Knöfler Ralf , Bakchoul Tamam , Jurk Kerstin 
Published: January 2025

AbstractCongenital platelet disorders are rare and targeted treatment is usually not possible. Inherited platelet function disorders (iPFDs) can affect surface receptors and multiple platelet responses such as defects of platelet granules, signal transduction, and procoagulant activity. If iPFDs are also associated with a reduced platelet count (thrombocytopenia), it is not uncommon to be misdiagnosed as immune thrombocytopenia. Because the bleeding tendency of the different platelet disorders is variable, a correct diagnosis of the platelet defect based on phenotyping, function analysis, and genotyping is essential, especially in the perioperative setting. In the case of a platelet receptor deficiency, such as Bernard–Soulier syndrome or Glanzmann thrombasthenia, not only the bleeding tendency but also the risk of isoimmunization after platelet transfusions or pregnancy has to be considered. Platelet granule disorders are commonly associated with either intrinsically quantitative or qualitative granule defects due to impaired granulopoiesis, or granule release defects, which can also affect additional signaling pathways. Functional platelet defects require expertise in the clinical bleeding tendency in terms of the disorder when using antiplatelet agents or other medications that affect platelet function. Platelet defects associated with hematological-oncological diseases require comprehensive information about the patient including the clinical implication of the genetic testing. This review focuses on genetics, clinical presentation, and laboratory platelet function analysis of iPFDs with or without reduced platelet number. As platelet defects affecting the cytoskeleton usually show thrombocytopenia, but less impaired or normal platelet functional responses, they are not specifically addressed.
Patients Undergoing Manipulation under Anesthesia following Primary Total Knee Arthroplasty: Are Their Patient-Reported Outcome Measures Inferior?
Authors: Sirignano Michael N. , Rowe Robert S. , Gainer James C. , Royster Brett W. , Smith Langan S. , Altman Kyle M. , Yakkanti Madhusudhan R. , Malkani Arthur L. 
Published: January 2025

AbstractStiffness after total knee arthroplasty (TKA) can lead to decreased function and patient dissatisfaction. Manipulation under anesthesia (MUA) is often performed to improve range of motion (ROM); however, there is no consensus on indications or timing. The purpose of this study was to compare clinical results and patient-reported outcome measures (PROMs) between patients who underwent MUA versus those with an uncomplicated postoperative course following primary TKA. This was an institutional review board-approved retrospective review of 116 consecutive patients who underwent MUA from 2013 to 2019 following primary TKA due to stiffness. Indication for MUA was failure to achieve 105 degrees of knee flexion at 6 weeks following surgery. Five patients underwent revision surgery and 15 patients from the MUA group were excluded: 12 lost to follow-up and 3 deaths. The remaining 96 MUA patients were matched to 288 TKAs who did not require MUA or revision, all with a minimum 2-year follow-up. Patients who underwent MUA were younger (60.7 vs. 66.3 years, p < 0.001) and had less preoperative knee flexion (105.4 vs. 110.7 degrees, p < 0.001). There were five (4.9%) revisions in the MUA group: two instability, two chronic pain, and one arthrofibrosis. There were no differences between the groups with respect to postoperative Knee Society Knee Score, Western Ontario and McMaster Universities Osteoarthritis, Knee Injury and Osteoarthritis Outcome Score for Joint Replacement, Forgotten Joint Score-12, satisfaction, or complications. Satisfaction rates were 88.5% among MUA patients and 89.6% among non-MUA patients (p = 1.0). Patients undergoing MUA following TKA, using the criteria of failure to achieve 105 degrees of flexion by 6 weeks postoperatively, were able to achieve similar PROMs and satisfaction compared with a control group with a low incidence of revision due to persistent arthrofibrosis.
Optical properties of 2D GeTe under strain: A DFT study
Authors: Ruiz-Cigarrillo O. , Flores-Rangel G. , Zavala-Moran U. , Puebla J. , Balderas-Navarro R. E. , Mizaikoff B. 
Published: January 2025

Monolayer germanium telluride (GeTe) exhibits tunable electronic and optical properties, making it promising for device applications. Using Density Functional Theory (DFT), we investigate the impact of uniaxial strain, ϵ, on its band structure and dielectric function (DF), ε̃. Tensile strain along the —zigzag direction induces a direct-to-indirect bandgap transition at ϵ = 2%, reducing the gap from 1.80 to 1.62 eV. Compressive strain narrows the gap while maintaining its indirect nature. Strain also induces in-plane anisotropy in the DF and shifts the optical absorption spectrum. We determine a deformation potential (DP) of −6.45 eV for the bandgap under tensile strain and DPs for other above bandgap high-symmetry points. These findings highlight the potential of strain engineering for tuning GeTe’s properties in devices.
Chronic stress–induced cholesterol metabolism abnormalities promote ESCC tumorigenesis and predict neoadjuvant therapy response
Authors: Wang Ting , Wang Xiangyu , Wang Keke , Yu Mengyuan , Bai Ruihua , Zhang Yiru , Zhang Zihan , Liu Feifei , Wang Rui , Shi Xiaodan , Jia Ludan , Liu Kangdong , Li Xiang , Jin Guoguo , Zhao Simin , Dong Zigang 
Published: January 2025

Recent studies have demonstrated that chronic stress can enhance the development of multiple human diseases, including cancer. However, the role of chronic stress in esophageal carcinogenesis and its underlying molecular mechanisms remain unclear. This study uncovered that dysregulated cholesterol metabolism significantly promotes esophageal carcinogenesis under chronic stress conditions. Our findings indicate that the persistent elevation of glucocorticoids induced by chronic stress stimulates cholesterol uptake, contributing to esophageal carcinogenesis. The activated glucocorticoid receptor (GCR) enrichment at the promoter region of High Mobility Group Box 2 (HMGB2) facilitates its transcription. As a transcription coactivator, HMGB2 enhances Sterol Regulatory Element Binding Transcription Factor 1 (SREBF1) transcription and regulates cholesterol metabolism through LDL particle uptake into cells via Low Density Lipoprotein Receptor (LDLR). These results emphasize the significant impact of chronic stress on esophageal carcinogenesis and establish cholesterol metabolism disorder as a crucial link between chronic stress and the development of ESCC. The implications suggest that effectively managing chronic stress may serve as a viable strategy for preventing and treating ESCC.
Sustainable plant-based control strategies for late blight disease of potato
Authors: Hari Amal , Echchgadda Ghizlane , Benjelloun Meryem , Lahmamsi Haitam , Belabess Zineb , Laasli Salah-Eddine , Mokrini Fouad , Lazraq Abderrahim , Lahlali Rachid 
Published: January 2025

Abstract

Despite the importance of potato crops for food security, it is threatened by fungal diseases. Late blight caused by
Phytophthora infestans
is one of the oomycetes that pose a major threat to global potato production. In this review, we compiled the recent data on
P
.
infestans
impacts on potato crops with a focus on the management approaches. We discussed the impacts of the mycelium and sporangia on leaves, tuber, and crops of potato plants in the field and during storage. Concerning the management approaches, we demonstrated the negative impacts of chemical fungicides on the environment and public health, as well as the development of resistance in treated
P
.
infestans
. Further, we analyzed the eco-friendly methods with a focus on natural products such as medicinal plant extracts and microbial agents. Essential oils (EOs) and extracts of medicinal plants showed higher antifungal activities against mycelium and spores of
P
.
infestans
due to their richness in chemical compounds such as polyphenols, flavonoids, sterols, terpenoids, and alkaloids. These biomolecules impact membranes, mitochondria, enzymes, and hyphae of the pathogen cells. Due to the lower stability of plant extracts, nanotechnologies such as nanoencapsulation of biomolecules and EOs were also discussed to clarify their promoting role in enhancing the antifungal activities of plant derivatives. Other modern methods such as RNA interference and biological control agents (BCAs) were also included. In the end, we discussed the limits and challenges of the eco-friendly approaches to demonstrate their ability to substitute the chemical fungicides.
Study on the influence of the Cu ribbon detachment ratio on the electrical characteristics of photovoltaic modules
Authors: Feng Ping , Li Lei , Tu Jielei , Xu Delin , Yang Yanyun , Zhang Qixing , Xu Zhangyang , Deng Qi , Kong Lingfu , Hou Jiahui 
Published: January 2025

Abstract
Based on the carrier transport path at the welding interface of a Cu ribbon, this study proposes a theoretical model of the Cu ribbon detachment ratio (DR) and the busbar resistance, Cu ribbon resistance, and contact resistance. The relationship between the Cu ribbon DR and the resistance of each welding layer, as well as the relative contribution of the resistance of each welding layer to the series resistance, is analyzed using the designed theoretical model. The results show that with the increase in the DR value, both the busbar resistance and contact resistance increase exponentially, whereas the Cu ribbon resistance decreases linearly. The effects of the busbar resistance, Cu ribbon resistance, and contact resistance on the series resistance are 36.22%, 0.40% and 63.38%, respectively. The results also indicate that series resistance is mainly affected by the busbar resistance and contact resistance. The maximum value of the Cu ribbon detachment was quantitatively calculated, when the DR value is larger than 93%, the detachment of the Cu ribbon can make a photovoltaic (PV) module retired. In this study, PV modules with Cu ribbons having different DR values are fabricated and tested in the laboratory. The results show that the maximum relative errors of the series resistance, fill factor, and output power of the values calculated by the proposed model and experimental test values are 4.77%, 1.05% and 1.40%, respectively. This verifies the feasibility of the proposed theoretical model. Finally, based on the relative contribution of the resistance of each welding layer to the series resistance, this study designs a B-type PV module with a thick-busbar and short-welding Cu ribbon. The results show that the electrical performance of the B-type PV module with a busbar thickness of 30 μm a welding length of the Cu ribbon of 70% performs.