bluuebunny/crossref_metadata_2025_split huggingface dataset:
Patterns in Domestic Injuries and how COVID-19 Lockdown Measures Changed Their Incidence in Mexico
Authors: García-González Gabriel , Muñoz-Maldonado Gerardo Enrique 
Published: December 2023

Abstract
Domestic accidents occur worldwide. From small burns and bruises to significant wounds and injuries from dangerous falls, not all of them reach clinical care; so to measure the toll of these hardships on society, we surveyed three major cities in Mexico to better understand the problem and how coronavirus disease 2019 (COVID-19) lockdown measures changed the incidence rate.
We conducted an analytical cross-sectional study using Microsoft Forms, with a digital survey distributed among the Mexican population from October 2021 to November 2021, during lockdown. The incidence of all injuries surveyed increasedduring the first year of the COVID-19 pandemic. A comparison of the time spent inside the house before and during the pandemic showed that only burns increased. The number of wounds and musculoskeletal injuries decreased as people spent more time at home. Women were shown to be the most vulnerable group.
This study offers an unprecedented perspective on home-related trauma, as past literature has mainly examined trauma injuries treated in hospitals. The types of wounds have morphed depending on the percentage of time spent in the house, which has undergone a remarkable transformation since the lockdown was enacted.
A prospective study of multimodal cocktail intercostal injection for chest pain relief after costal cartilage harvest for ear reconstruction
Authors: Jiang Dongwen , Dong Wenfang , Shang Qiaoli , Ma Chenhao , He Leren , Feng Yanjun 
Published: December 2023

Abstract
Chest pain is one of the most common complaints after costal cartilage harvest.The present study aimed to compare the effectiveness of intraoperative area local injection after costal cartilage harvest when mixed drugs or ropivacaine plus analgesic pump is used, as measured by visual analogue scale (VAS) scores, rescue analgesic consumption, postoperative movement steps, and related complications. Eligible microtia patients who underwent costal cartilage harvest during ear reconstruction were randomly assigned to either a mixed drugs injection group (mixed drugs group) or ropivacaine plus analgesic pump group (analgesic pump group).The VAS scores in the mixed drugs group were significantly lower than those in the analgesic pump group at rest (p < 0.05) and the VAS scores in the mixed drugs group were significantly lower than those in the analgesic pump group during coughing (p < 0.05) before 96h after surgery. Rescue analgesic consumption and rate of complications were significantly lower in the mixed drugs group compared with the analgesic pump group (all p<0.05). Postoperative mobility of patients was significantly higher in the mixed drugs group compared with the analgesic pump group(p < 0.05).In conclusion, compared with ropivacaine plus analgesic pump, local injection of mixed drugs reduced chest pain after costal cartilage harvest for microtia ear reconstruction with less rescue analgesic consumption and complications, improved the postoperative movement steps of patients.
The influence of loose layer water cut-off curtain on the slope stability of open-pit coal mines
Authors: Wang Hai 
Published: December 2023

Abstract

Water-rich open-pit mines in China face the problems of large water inflow, slope reinforcement difficulties and high mining risks. The construction of a water cut-off curtain to control groundwater in the loose layer of open-pit mines can effectively reduce the amount of water drainage, thus solving the problem of flooding in open-pit mines. However, the rise of the water level outside the curtain and the change in the geotechnical properties of the slope will affect the stability and safety of the slope of the open-pit mine. A computational model was constructed, and the limit equilibrium method and numerical simulation method were used for calculation and analysis to study and analyse the influence law of the water cut-off curtain of the loose layer on the stability of the slope. The research results show that under the effect of the water cut-off curtain, the water level on the outside of the cut-off curtain in the loose layer of the open-pit mine continues to rise, and the hydrostatic pressure and horizontal thrust of the slope body increase. As a result, the sliding force of the slope increases and the anti-skid force decreases, ultimately leading to a decrease in the slope stability coefficient of the open-pit. Assuming that the water level outside the curtain remains unchanged, if the construction position of the curtain is moved outwards, the stability coefficient of the slope will increase; conversely, if the position of the curtain is moved inwards, the stability coefficient of the slope will decrease. The maximum shear stress on the slope increases as the water level outside the water curtain rises. The maximum shear stress is mainly concentrated at the toe of the slope of the first platform below the surface and at the interface between the curtain and the bottom of the Quaternary System. The water curtain can control the water table. The water cut-off curtain can control the groundwater level of the slope and maintain slope stability.
On-site biosignal amplification using a single high-spin conjugated polymer
Authors: Lei Ting , Ge Gao-Yang , Xu Jingcao , Wang Xin , Sun Wenxi , Yang Mo , Mei Zi , Deng Xin , Li Peiyun , Pan Xi , Li Jia , Wang Xue , Zhang Zhi , Lv Shi , Dai Xiao 
Published: December 2023

Abstract

On-site or in-sensor biosignal transduction and amplification can offer several benefits such as improved signal quality, reduced redundant data transmission, and enhanced system integration1,2. A promising candidate for this purpose is ambipolar organic electrochemical transistors (OECTs) due to their favorable attributes, including high transconductance, low operation voltage, biocompatibility, and suitability for miniaturized amplifier design3,4. However, the performance of ambipolar OECT materials has remained limited, hindering their successful application in on-site biosignal amplification. Here, we propose to use high-spin, hydrophilic conjugated polymers and a computational screening approach to address this challenge. We designed a high-spin polymer, namely P(TII-2FT), which exhibits balanced and exceptionally high ambipolar OECT performance. The figure-of-merits achieved by the P(TII-2FT) devices surpass those of the current leading materials by 5 to 20 times, resulting in a remarkable voltage gain exceeding 800 V/V while maintaining a compact form factor. Based on the amplifier, we have successfully achieved on-site capture and amplification of various electrophysiological signals with greatly enhanced signal quality.
Gain of 1q confers an MDM4-driven growth advantage to undifferentiated and differentiating hESC while altering their differentiation capacity
Authors: Spits Claudia , Krivec Nusa , de Deckersberg Edouard Couvreu , Lei Yingnan , Delbany Diana Al , Regin Marius , Verhulst Stefaan , Grunsven Leo van , Sermon Karen 
Published: December 2023

Abstract

Gains of 1q are a highly recurrent chromosomal abnormality in human pluripotent stem cells. In this work, we show that gains of 1q impact the differentiation capacity to derivates of the three germ layers, leading to miss-specification to cranial placode and non-neural ectoderm during neuroectoderm differentiation and by poorer expression of lineage specific markers in hepatoblasts and cardiac progenitors. Competition assays show that the cells retain their selective advantage during differentiation, which is mediated by a higher expression of MDM4, a gene located in the common region of gain. MDM4 drives the winner phenotype of the mutant cells in both the undifferentiated and differentiating state by reducing the cells’ sensitivity to DNA-damage through decreased p53-mediated apoptosis. Finally, we find that cell density in culture plays a key role in promoting the competitive advantage of the cells by increasing DNA damage.
Risk Factors Affecting Delay of Initiating Adjuvant Chemotherapy for Stage III Colorectal Cancer
Authors: Maeda Shingo , Ouchi Akira , Komori Koji , Kinoshita Takashi , Sato Yusuke , Muro Kei , Taniguchi Hiroya , Masuishi Toshiki , Ito Seiji , Abe Tetsuya , Shimizu Yasuhiro 
Published: December 2023

Abstract
Purpose
Delay in initiating adjuvant chemotherapy after curative resection of colorectal cancer has been reported to lead to poor prognosis, but few studies have looked at associated factors. This study aimed to identify risk factors for delay in initiating adjuvant chemotherapy.
Methods
Data from 200 consecutive patients who underwent curative resection and adjuvant chemotherapy for Stage III colorectal cancer between 2013 and 2018 were retrospectively collected and analyzed.
Results
Adjuvant chemotherapy was initiated more than eight weeks after surgery in 12.5% of patients (delay group). Compared to those with no delay (non-delay group), patients in the delay group had significantly higher rates of synchronous double cancers (2.3% vs. 16.0%, p = 0.001), preoperative bowel obstruction (10.3% vs. 32.0%, p = 0.003), laparotomy (56.0% vs. 80.0%, p = 0.02), concomitant resection (2.9% vs. 24.0%, p < 0.001), and postoperative complications (32.0% vs. 56.0%, p = 0.02), and a significantly longer length of hospital stay (median 12 vs. 30 days, p < 0.001). In multivariate analysis, synchronous double cancers (odds ratio 10.2, p = 0.008), preoperative bowel obstruction (odds ratio 4.6, p = 0.01), concomitant resection (odds ratio 5.2, p = 0.03), and postoperative complications of Clavien-Dindo grade ≥ IIIa (odds ratio 4.0, p = 0.03) were identified as independent risk factors for delay in initiating adjuvant chemotherapy.
Conclusion
Careful treatment planning is necessary for colorectal cancer patients with synchronous double cancers, preoperative bowel obstruction, and concomitant resection to avoid delay in initiating adjuvant chemotherapy.
The Effect of Dynamic Tape's Directional Support on Shoulder Fatigue and Pitching Performance in Amateur Baseball Players: A Randomized Crossover Trial
Authors: Huang Haw-Ming , Hsu Chih Yang , Hsieh I-Fan , Yang Po-Chieh , CHENG YU-HSUAN 
Published: December 2023

Abstract
This study aimed to assess the impact of applying Dynamic tape to the pitching shoulder on shoulder fatigue, delayed onset muscle soreness, and performance improvement. A randomized crossover study, with participants and assessors blinded, included 20 amateur adult baseball players without shoulder pain. Sham taping and Dynamic taping were alternated, using an internal rotation support taping method in both groups. Strengths and range of motion in bilateral shoulders were measured with a handheld dynamometer and protractor before and after each test. Percentage of strength decrease, pitch velocity, spin rate, and shoulder pain were recorded. The Dynamic tape group showed a significant reduction in internal rotation strength decline compared to the sham group (-1.4% vs. 7.0%, p = 0.03). However, no significant differences were observed in other strength declines, shoulder range of motion, pain, pitching velocity, or spin rate. Dynamic tape reduced direction-specific shoulder fatigue but did not significantly enhance pitching performance or prevent delayed onset muscle soreness.
Structure of a Rhs effector clade domain identifies new mechanistic insights into type VI secretion system toxin delivery.
Authors: McGowan Sheena , Hayes Brooke , Harper Marina , Venugopal Hariprasad , Lewis Jessica , Wright Amy , Steele Joel , Steer David , Schittenhelm Ralf , Boyce John 
Published: December 2023

Abstract

The type VI secretion system (T6SS) is a molecular machine utilised by many Gram-negative bacteria to deliver antibacterial toxins directly into adjacent bacteria, often providing a competitive advantage. Rearrangement hotspot (Rhs) effectors are known T6SS cargo effectors, but the precise delivery and activation of these toxins is poorly defined. We present the structure of a novel T6SS Rhs effector (Tse15) from the multidrug resistant nosocomial pathogen Acinetobacter baumannii. Tse15 forms a triple layered β-cocoon Rhs domain with an N-terminal α-helical clade domain and an unfolded C-terminal toxin domain located entirely inside the Rhs cage. We identify that Tse15 is cleaved into three domains, through two independent auto-cleavage events involving aspartyl protease activity for toxin self-cleavage and a nucleophilic glutamic acid for the cleavage of the N-terminal clade domain. Proteomic analyses showed that the N-terminal clade and toxin domains, but not the β-strand rich Rhs cage, are delivered outside of the cell, suggesting a novel mechanism for Rhs toxin delivery and activation. Our findings suggest that this delivery mechanism requires an interaction between the N-terminal clade and toxin domains, with the clade domain acting as the internal chaperone to mediate tethering of the toxin to the T6SS machinery. Conservation of the clade domain in other Gram-negative bacteria suggest this may be a common mechanism for T6SS toxin delivery.
Theoretical insights from adsorption of ofloxacin using Zn2SnO4/reduced graphene oxide composite
Authors: Castro Janevane , Oliveira Renato , Bezerra Lucas , Souza-Júnior José , Chaves Anderson , Correia Adriana , Monteiro Norberto 
Published: December 2023

Abstract
Emerging Contaminants (ECs), such as pesticides, steroid hormones, antibiotics growth accelerators, and inhibitors of pathogenic microorganisms, among others, have become an increasingly severe and worrying problem to ecosystems and human health, including the contamination of water bodies. Therefore, it is imperative to seek ways to measure and evaluate the current conditions of various environmental matrices so that urgent strategies can be planned and designed to mitigate the spread of these contaminants. Ofloxacin, a widely prescribed antibiotic, is resistant to biological degradation and promotes bacteria resistance, being considered environmentally maleficent. In this sense, this work arises to theoretically study the adsorption of ofloxacin (OFL) on two surfaces (zinc stannate (Zn2SnO4) and reduced graphene oxide (rGO)), considering that OFL is classified as a toxic organic EC and, therefore, it is imperative to develop analytical methodologies for their removal. Furthermore, all theoretical calculations were carried out in the CASTEP software using Density Functional Theory (DFT) and the GGA functional, obtaining results for adsorption energy, band structure and Total Density of States (TDOS). The results showed that adsorption occurs more effectively with Zn2SnO4 (1 0 0), with an adsorption energy of -21.03 eV, compared to -1.90 eV in the rGO surface (1 0 0), and that the metallic character of this compound did not change after OFL adsorption. However, the OFL-Zn2SnO4 complex had more states to be occupied. Furthermore, it was observed that the OFL-rGO complex presented a greater semiconductor character.
NeuroWorm: a Long-term Implantable Soft Microfibre for Multimodal Biosensing
Authors: Liu Zhiyuan , Xie Ruijie , Yu Qianhengyuan , Li Dong , Han Xu , Xu Xiaolong , Huang Jianping , Zhou Xiaomeng , Zhao Hang , Deng Xinping , Tian Qiong , Li Qingsong , Li Hanfei , Zheng Hairong , Li Guanglin , Zhu Meifang , Yan Wei , Han Fei , Xu Tiantian 
Published: December 2023

Abstract
Long-term implantable bioelectronics can efficiently evaluate the function of the nervous system and serve as effective human-machine interfaces. Here, inspired by earthworms, we introduce NeuroWorm, a soft and stretchable fibre sensor for bio-signal monitoring. Our approach involves rolling to transform 2D bioelectronic devices into 1D NeuroWorm, resulting in a soft, multifunctional microfibre housing over 60 longitudinally-distributed electrodes for bio-electric and -mechanical monitoring. It can be implanted in muscle with tiny incision for 8-month bio-electrical monitoring in rats. Importantly, after 13-month implantation, the fibroblast encapsulation around the fibre is negligible. Moreover, it can wander inside a brain under magnetic field. This strategy not only facilitates the development of multi-channel and multi-functional soft and stretchable fibre-shaped NeuroWorm sensors but also offers a platform for unprecedently long-term minimally-invasive implantable bioelectronics.
Coupled effects of land-use patterns and hydrological regimes on fecal indicator bacteria in a coastal watershed
Authors: Huang Yicheng , Wang Jian , Xie Zheyu , Huang Jinliang 
Published: December 2023

Abstract
Monitoring and assessing fecal indicator bacteria (FIB) can inform aquatic ecosystem health and management. However, knowledge of the patterns of fecal coliforms and the underlying mechanisms in rivers is still limited. In this study, we aimed to investigate the coupled effects of land-use patterns and hydrological regimes on FIB patterns in a subtropical coastal watershed, the Jiulong River Watershed (JRW). Water samples were collected quarterly for nutrient and FIB measurements across the watershed, from October 2020 to July 2021. The results indicate that Escherichia coli and Fecal E. coli concentrations peaked in summer and autumn, with significantly higher concentrations observed in urban watersheds than in natural watersheds. Redundancy analysis further revealed that of the four sampling seasons, the relative contribution of land use to FIB characteristics in the JRW was the highest in autumn, whereas that of water quality was the highest in the other three seasons. Water flow showed the lowest relative contribution in all the seasons and a positive correlation between high nutrient concentrations and E. coli counts exhibited. This study enhances our understanding on the coupled effects of seasonal hydrological regimes and land-use patterns on FIB characteristics, which might provide implications for mitigating the risk of E. coli contamination in similar human-impacted watersheds.
A comparison of two systems for group housing of sows - effects on productivity, removal, and treatments
Authors: SYLVÉN KAISA RYYTTY , WALLGREN TORUN , ALMERHEIM PONTUS , SELLING LENA ELIASSON- , JACOBSON MAGDALENA , WALLGREN PER 
Published: December 2023

Abstract

Background
Group housing of sows has been extensively studied since the EU banned gestation crating. Well-managed group housing promotes sow welfare, but the impact varies based on factors such as feeding, group characteristics, and environmental features etc. Adequate floor space, particularly directly post-mixing, is crucial for social interactions, innate behaviours, and to reduce injuries caused by aggression. The aim of this study was to compare two group housing systems for pregnant sows with respect to productivity, treatment frequency, and removal of sows.
Results
The mean parity number was 3.1 ± 1.3 in both groups. Sows housed in System I with large groups (n = 40) in large pens with deep litter straw gave birth to 16.8 ± 0.33 (Least Squares Means, LSM) piglets, compared to 15.4 ± 0.31 (LSM) for sows in System II kept in smaller groups (n = 8–10) in smaller pens (p = 0.0005). Medical treatments of sows were more frequent (p < 0.001) in System II. The incidence of replacement of sows was comparable in both systems, and there was a high occurrence of sows becoming pregnant during the subsequent insemination in both groups.
Conclusions
This study indicated that sows kept in larger groups provided with a larger floor space (a total area of 156 m2, corresponding to 3.9 m2 per sow) and housed on deep straw had a higher number of liveborn and weaned piglets and lower incidence of antibiotic treatments than sows with less floor space (a total area of 24.5 m2, corresponding to 2.5–3.1 m2 per sow) and less bedding/manipulable material. Increased total floor space appeared to alleviate the negative effects of mixing, even in larger groups.
Reducing Time to Diagnosis of Rare Genetic Diseases in a Medically Underserved Hispanic Population- Lessons Learned for Meaningful Engagement
Authors: Vuocolo Blake , Sierra Roberta , Brooks Dan , Holder Christopher , Urbanski Lauren , Rodriguez Keila , Gamez Jose David , Mulukutla Surya Narayan , Berry Lori , Hernandez Ana , Allegre Alberto , Hidalgo Humberto , Rodriguez Sarah , Magallan Sandy , Gibson Jeremy , Bernini Juan Carlos , Watson Melanie , Nelson Robert , Mellin-Sanchez Lizbeth , Dai Hongzheng , Soler-Alfonso Claudia , Carter Kent , Lee Brendan , Lalani Seema R. 
Published: December 2023

Abstract

Background
The utilization of genomic information to improve health outcomes is progressively becoming more common in clinical practice. Nonetheless, disparities persist in accessing genetic services among ethnic minorities, individuals with low socioeconomic status, and other vulnerable populations. The Rio Grande Valley at the Texas-Mexico border is predominantly Hispanic with a high poverty rate and an increased prevalence of birth defects, with very limited access to genetics services. The cost of a diagnosis is often times out of reach for these underserved families. Funded by the National Center for Advancing Translational Sciences (NCATS), Project GIVE (Genetic Inclusion by Virtual Evaluation) was launched in 2022 to shorten the time to diagnosis and alleviate healthcare inequities in this region, with the goal of improving pediatric health outcomes.
Methods
Utilizing Consultagene, an innovative electronic health record (EHR) agnostic virtual telehealth and educational platform, we designed the study to recruit 100 children with rare diseases over a period of two years from this region, through peer-to-peer consultation and referral.
Conclusions
Project GIVE study has allowed advanced genetic evaluation and delivery of genome sequencing through the virtual portal, effectively circumventing the recognized socioeconomic and other barriers within this population. This paper explores the successful community engagement process and implementation of an alternate genomics evaluation platform and testing approach, aiming to reduce the diagnostic journey for individuals with rare diseases residing in a medically underserved region.
Comparing Bayesian models for genetic evaluation of oocytes and embryo counts in Dairy Gir cattle
Authors: Feltes Giovani Luis , Campos Gabriel Soares , Raidan Fernanda Santos Silva , Feres Luiz Fernando Rodrigues , Ribeiro Virgínia Mara Pereira , Cobuci Jaime Araujo 
Published: December 2023

Abstract
Count traits are usually explored in livestock breeding programs and it usually does not fit into Normal distribution, requiring alternatives to adjust the phenotype to estimate accurate genetic parameters and breeding values. Alternatively, distribution such as Poisson can be used to evaluate count traits. This study aimed to compare and discuss the genetic evaluation for oocyte and embryo counts considering Gaussian (untransformed variable – LIN, transformed by logarithm – LOG, transformed by Anscombe – ANS) and Poisson (POI) distributions. The data comprised 11343 total oocytes, viable oocytes, cleaved embryos, viable embryos records of ovum pick-up from 1740 dairy Gir heifers and cows. The genetic parameters and breeding values were estimated by the MCMCglmm package of the R software. The posterior means of heritability varied from 0.40 (LIN) to 0.49 (POI) for TO; 0.39 (LIN) to 0.49 (POI) for VO; 0.30 (LOG) to 0.41 (POI) for CE; 0.19 (LIN) to 0.32 (POI) for VE, respectively. The posterior means of repeatability varied from 0.56 (LIN) to 0.65 (POI) for TO; 0.53 (LOG) to 0.63 (POI) for VO; 0.44 (LOG) to 0.60 (POI) for CE; 0.36 (LOG) to 0.56 (POI) for VE, respectively. Deviance information criterion and mean squared residuals indicated that POI model should be used for genetic evaluation of embryo and oocytes count traits. The Spearman rank correlation between estimated breeding value (EBV) for embryo and oocytes count traits computed by POI, LOG, and ANS models was high (ranging from 0.77 to 0.99), indicating little reordering among the best animals. The POI model is the most adequate for genetic evaluation, resulting in more reliable EBV for Dairy Gir cattle of oocyte and embryo counts traits.