bluuebunny/crossref_metadata_2025_split huggingface dataset:
THE STUDY OF THE CLEANING EFFECT OF THE SPRAY FOR THE PREVENTION OF CARIES «DENTABALANCE®» SYNBIOTIC COMPLEX INCLUDING LYSATE FROM STREPTOCOCCUS THERMOPHILUS AND PREBIOTICS AS AN INTERMEDIATE MEANS OF ORAL HYGIENE
Authors: Ulitovskiy Sergey , Sadovski Vladimir , Kalinina Olga , Leontiev Alexander , Rusakova Elena , Bukov Denis 
Published: November 2023

Background. The problem of controlling the formation and development of dental plaque as a risk factor for the development of dental diseases is leading in preventing a decrease in the level of oral hygiene. In this regard, it remains relevant to study the preventive effects of liquid oral hygiene products with an anti-carious effect. Spray for the prevention of caries «DentaBalance®» synbiotic complex including lysate from Streptococcus Thermophilus and prebiotics, plant extracts that prevent the adhesion of bacteria to the surface of the teeth. At the same time, the metabolism of microorganisms that form plaque is disrupted, leading to their death, and the amount of acids produced by bacteria is also reduced, which increases the level of dental health.
Material and methods. In the conditions of the clinic, a spray for the prevention of caries was tested in order to determine its cleansing effect as an intermediate oral hygiene product used during the day. The spray for the prevention of caries «DentaBalance®» synbiotic complex was used by probants independently 2 times a day for 30 days for intermediate use during the day. Repeated examinations were carried out every two weeks, for 4 weeks. The control of the cleansing effect of the intermediate liquid oral hygiene product was carried out for 30 days. The assessment was carried out according to the Green-Vermillion index using indicators of dental deposits.
Results. Based on the results of the study, the cleansing effect according to the Green - Vermillion index was established in persons who used the spray for the prevention of caries «DentaBalance®» synbiotic complex during the day, by the end of 4 weeks was 50.66 ± 0.51. The data obtained were confirmed by statistical processing of the results of the study.
Conclusion. It has been established that the spray for the prevention of caries «DentaBalance®» synbiotic complex has a pronounced cleansing effect when used during the day, which is confirmed by its cleansing effectiveness. Batch spraying of liquid hygiene products in the dosage form of the spray effectively delivers microparticles with their active components, and also ensures its mobility in use.
Teaching in a COVID-19 pandemic: perceptions and practices of university faculty in Spain
Authors: Sánchez-Tarazaga Lucía , Sanahuja Aida , Colomer Carla , Ferrández-Berrueco Reina 
Published: November 2023

The full impact of the COVID-19 crisis on higher education remains unclear, with some topics still under-researched. This research explores the challenges faced by Spanish academics during emergency remote teaching and is a pioneering study in this context due to the number of participating universities and variety of profiles of university faculty. Three focus groups were conducted to gain a deeper understanding on two dimensions: academic (methodology, materials, assessment, workload and institutional response) and personal (socio-emotional dimension, work–life balance and learnings). The main findings revealed the extensive adaptation of university faculty to the new situation and collected a series of teaching strategies. The conclusions reflect on the role that universities should play in the coming years, not only in the Spanish context but also at an international level. Most importantly, our findings can be taken into consideration for further research and teacher education policy in higher education.
Received: 15 March 2022 Accepted: 24 July 2023
Procesos de intervención y estado de conservación del conjunto edificatorio del Museo Nacional de Costa Rica
Authors: Porras-Alfaro David , Méndez-Álvarez Dawa , García-Baltodano Kenia 
Published: November 2023

A través de la patología de la construcción es posible definir el estado de conservación de las edificaciones. Por ello, en el marco del proyecto de investigación ‘Implementación de técnicas no invasivas para el estudio patológico en edificaciones patrimoniales’, se eligió como caso de estudio el Museo Nacional de Costa Rica, por ser un conjunto de edificaciones patrimoniales emblemáticas y protegidas por ley, en las cuales se analizaron lesiones en diversos tipos de materiales y variados sistemas constructivos del siglo XIX y XX utilizados comúnmente en el país. Además, en el cual se han desarrollado una serie de intervenciones, al menos durante los últimos 15 años para conservar y refuncionalizar el conjunto.
Como parte del trabajo realizado, se llevó a cabo un proceso de documentación de las intervenciones previas en los inmuebles y se identificaron las lesiones mecánicas, químicas y físicas actuales, mediante levantamiento en campo. Esta información se sistematizó a través de 27 fichas detalladas y planos arquitectónicos con la respectiva localización de las lesiones conforme a su clasificación.
Con la información obtenida se desarrolló un expediente digital que sistematiza estos procesos. Esta documentación permitirá mejorar los métodos de conservación preventiva y contar con un registro histórico de este conjunto edificatorio.
Analisi Dampak Ekonomi Pengolahan Kopi Arabika pada Kelompok Tani Sumber Karya Empat Kabupaten Bondowoso
Authors: Setyokuncoro Bagus , Nazhat Lak lak , Prastowo  
Published: November 2023

Kopi merupakan salah satu komoditas pertanian yang dapat memberikan dampak terhadap petani pengolahnya. Peneltian ini bertujuan menganalisis dampak ekonomi yang timbul dari kegiatan pengolahan. Metode analisis diskriptif kuantitatif digunakan dalam penelitian ini untuk menggambarkan dampak yang diakibatkan kegiatan pengolahan kopi terhadap kelompok tani, adapun penelitian ini dilakukan pada kelompok tani Sumber Karya Empat Kabupaten Bondowoso. Hasil penelitian menunjukkan bahwa adanya kegiatan pengolahan kopi pada kelompok tani Sumber Karya Empat dapat memberikan dampak ekonomi yang baik bagi anggota kelompok khusunya dan masyarakat pada umumnya. Adapun dampak ekonomi yang dirasakan anggota kelompok secara langsung (direct impact) dapat mencapai lebih dari delapan ratus juta rupiah sedangkan untuk dampak ekonomi tidak langsung (indirect impact) lebih dari tujuh ratus juta rupiah dan dampak ekonomi bagi terdampak lain atau (induce Impact ) mencapai lebih dari empat ratus juta rupiah.
Pengaruh Kebijakan Dividen terhadap Nilai Perusahaan pada Perusahaan Manufaktur di Indonesia
Authors: Khoirina Noor Anindya  , Mellisa Fitri Andriyani Muzakir  
Published: November 2023

Kebijakan dividen merupakan sebuah keputusan krusial yang dilakukan oleh perusahaan untuk menjaga hubungan baik dengan para investor yang berkaitan juga dengan nilai perusahaan. Penelitian ini bertujuan untuk menguji pengaruh kebijakan dividen yang dimoderasi oleh terhadap nilai perusahaan pada sektor manufaktur di Indonesia. Data yang digunakan dalam penelitian ini adalah data sekunder dari Bursa Efek Indonesia dengan periode 5 tahun (2015-2019). Menggunakan regresi linear berganda dengan metode estimasi Generalized Least Square (GLS), hasil penelitian menunjukkan bahwa kebijakan dividen tidak berpengaruh terhadap nilai perusahaan, likuiditas berpengaruh terhadap nilai perusahaan, dan kebijakan dividen berpengaruh positif terhadap nilai perusahaan dimoderasi oleh likuiditas.
Dividend policy is a crucial decision by a firm to maintain a good relationship with the investor and relate to firm value. The purpose of this research is testing the effect of dividend policy which moderated by liquidity to firm value in manufacturing sector. The data type is secondary data from Indonesia Stock Exchange in 5 years period (2015-2019). Using multiple linear regression with Generalized Least Square (GLS) estimation method, the results show that dividend policy does not have a significant effect on firm value, liquidity has a significant effect on firm value and dividend policy have a significant effect on firm value moderated by liquidity.
Analisis SIA Berupa POS PBB Terhadap Pemberian Keringanan Wajib Pajak Pada BPKAD Kota X
Authors: Dwikamba Javier Erlandaffa Satria , Neni  
Published: November 2023

This study aims to determine the efficiency of using an accounting information system (AIS) in the form of a payment online system for land and building tax (POS PBB) for providing taxpayer relief. The research conducted is descriptive research with a qualitative approach. The sources and data for this research were obtained from the BPKAD kota Yogyakarta. The research data in this study were interviews and observation as primary data and documents as secondary data. results of the analysis of this study, can be concluded that the Analysis of AIS in the Form of Using POS PBB for the Provision of Taxpayer Relief at BPKAD Kota Yogyakarta is running well and efficiently, and the provision of menus by the activities of providing PBB relief to taxpayers makes it easier reviewers in reviewing existing relief files. Even though the use of the PBB POS application is efficient, problems with using the application can still be found, both in the form of system errors and human errors. To minimize these obstacles, BPKAD Kota Yogyakarta made efforts in the form of procurement of hardware and software; training for work units; and collaboration with the internal and external parts of BPKAD kota Yogyakarta.
THE EFFECT OF PBL ASSISTED BY PhET SIMULATION ON CRITICAL THINKING SKILLS IN CLASS VI SCIENCE LEARNING AT ELEMENTARY SCHOOLS IN THE BANYUMUDAL CLUSTER, KEBUMEN REGENCY, ACADEMIC YEAR 2022/2023
Authors: Salsabila Nafisa , Suryandari Kartika Chrysti , Salimi Moh 
Published: November 2023

<em><span>Problem Based Learning equipped by PhET Simulation multimedia is a factor influencing student's critical thinking skills. The study aimed to examine: (1) the influence of Problem Based Learning equipped by PhET Simulation multimedia on critical thinking skills in natural science to sixth grade students and (2) the effectiveness of Problem Based Learning equipped by PhET Simulation multimedia on critical thinking skills in natural science to sixth grade students. This quantitative research design is quasi-experimental. The samples were 48 students from SDN 2 Panjer and SDN 1 Panjer. The study was conducted in 6 months. The sampling technique used purposive sampling. The results indicated that: (1) on the independent sample t-test, the value of Sig. (2-tailed) was 0.046 &lt;0.05. (2) On the N-Gain test, the average value was 0.3923. It concludes that there are significant influences and effectiveness of Problem Based Learning equipped by PhET Simulation multimedia on critical thinking skills in natural science to sixth grade students of public elementary schools at Banyumudal Cluster, Kebumen Regency, in academic year of 2022/2023. This is in line with the advantages of PhET Simulation which makes it easier for students to explore their own knowledge critically. This research can be a reference for future research in the development of students' critical thinking skills.</span></em>
ANALYSIS OF PEDAGOGIC COMPETENCE OF ELEMENTARY SCHOOL TEACHERS IN GARUT REGENCY
Authors: Nurkamilah Siti 
Published: November 2023

<em><span>Pedagogic competence is one of the four main competencies that must be mastered by teachers. This study aims to determine the analysis of pedagogic abilities of elementary school teachers in Garut Regency and analyze which pedagogic competence indicators have the best mastery and which competency indicators are still lacking from elementary school teachers in Garut Regency. The research method used is a descriptive method with a quantitative approach. The population of this study was elementary schools located in Garut Regency, while the sample of this study was 39 teachers from several schools in Garut Regency. The instrument used is a questionnaire. The results showed that the pedagogic competence of teachers in Garut Regency was classified as Good with an average score of 85.93. The greatest value lies in the indicator of the ability to communicate effectively, empathically and politely with students and the indicator of the teacher's ability to master student characteristics, while for indicators that are still relatively low lies in the ability of teachers to organize educational learning and the ability to master learning theories and educational learning principles.</span></em>
Toxicity Study of Textile Materials from Natural and Synthetic Polymers Using Bioassay Techniques: Sperm Motility Inhibition Test and Daphnia magna Acute Immobility Test
Authors: Pekhtasheva Elena , Mastalygina Elena , Leonova Irina , Palanisamy Sivasubramanian , Palaniappan Murugesan , Karumuri Srikanth , Ayirilmis Nadir 
Published: November 2023

Abstract
Toxic characterization of textiles in relation to human health hazards is a challenging issue. 11 textile materials were tested by two methods for assessing toxicity of textile materials: sperm motility inhibition test (with bull spermatozoa) and Daphnia magna acute immobility test (with Daphnia magna Straus). The paper provides a comparative analysis of the advantages of each method for determining toxicity. It was proved that the toxicity assessment of textiles’ extracts based on the immobilisation of daphnids was characterized by comparable sensitivity and more simplicity of execution than the toxicity test by means of bull semen. It was shown that the presence of dyes and synthetic fibres had a major impact on the textiles’ toxicity. The aqueous extracts from uniformly dyed textiles were characterized by higher level of toxicity compared to the non-dyed ones (a toxicity index by motility inhibition test was 37-62%, an acute immobility parameter by D.magna test – 100% with reference to the control uncontaminated media).
Essential amino acid residues and catalytic mechanism of trans-epoxysuccinate hydrolase for production of meso-tartaric acid
Authors: Liao Hongxiu , Pan Haifeng , Yao Jinfeng , Zhu Ronglin , Bao Wenna 
Published: November 2023

Abstract

Objectives
This study aimed to discuss the essential amino acid residues and catalytic mechanism of trans-epoxycussinate hydrolase from Pseudomonas koreensis for production of meso-tartaric acid.
Results
The optimum conditions of the enzyme were 45°C and pH 9.0, respectively. It was strongly inhibited by Zn2+, Mn2+ and SDS. Michaelis-Menten enzyme kinetics analysis gave a Km value of 3.50 mM and a kcat of 99.75 s− 1, the EE value was higher than 99.9%. Multiple sequence alignment and homology modeling showed that the enzyme belonged to MhpC superfamily and had a typical α/β hydrolase folding structure. Site-directed mutagenesis indicated H34, D104, R105, R108, D128, Y147, H149, W150, Y211 and H272 were important catalytic residues. 18O-labeling study suggested the enzyme acted via two-step catalytic mechanism.
Conclusions
The structure and catalytic mechanism of trans-epoxycussinate hydrolase were firstly reported. Ten residues were critical for its catalysis and a two-step mechanism by an Asp-His-Asp catalytic triad were proposed.
Current Status and Future Projection of Soil Erosion Based on RUSLE, Landscape Ecology and Deep Learning Technologies: Observations from a Tropical River Basin in Eastern India
Authors: Roy Subha , Das Souvik , Chatterjee Jaya , Jaman Md. Hasanur , Sengupta Somasis 
Published: November 2023

Abstract

Soil erosion has contributed to loss of enormous amounts of top soil worldwide. Since the exact quantification of soil erosion is impossible, numerous researchers across the world have used prediction-based models (such as Revised Universal Soil Loss Equation, RUSLE) for assessing the temporal context of soil erosion at the catchment-scale. This paper has tried to integrate the RUSLE-based empirical soil erosion model and landscape ecology for the soils of a tropical river basin in Eastern India. It is observed that more than 60% of the areas in the studied basin are presently witnessing erosion greater than 11.2 tons/ha/year, which is above the tolerable limit as proposed by Food and Agricultural Organization (FAO). The process was applied for 2011 and 2021 and it was observed that soil erosion was augmented by about 6% during this period. Landscape ecological metrices reveal that the patches of high erosion are getting clustered and coalesced and becoming larger in areal extent, especially in the upper and middle domains of the studied basin. This paper, with the help of the soil erosion status of 2011 and 2021, has tried to predict the future scenario of soil erosion in the next five decades (2021 – 2071) with the help of the Artificial Neural Network, a popular deep learning technology. It is found that if erosion continues at the present rate, the patches may increase in extent by about 50% in the next five decades, which is detrimental. Finally, it is recognized that due to the lower clay content (< 30%) in the upper and middle domains of the basin, the study suggests the use of plot-scale mulching technique as an efficient measure to combat soil erosion in the region.
First Parechovirus reported case in Saudi Arabia in Hospitalized immunocompromised adult patient.
Authors: Alshammari abdullah , Alotaibi Jawaher , Almaghrabi reem , bawazeer Reema , Althawadi Sahar , Tayeb Hamsa 
Published: November 2023

Abstract

Human parechovirus, a member of the Picornaviridae family (PeVs), can lead to severe infections, including severe meningitis, meningoencephalitis, and sepsis-like syndrome. We report a case of human parechovirus-related encephalitis in a 52-year-old woman diagnosed with glioblastoma multiforme. She underwent surgical resection in June 2022. Unfortunately, her disease recurred, and she underwent a second resection in August 2022, followed by radiation therapy and Temozolomide therapy. She presented to the hospital with a few days of acute confusion followed by seizures, necessitating intubation for airway support. A cerebrospinal fluid (CSF) sample was obtained and processed using the Biofire FilmArray, which reported the detection of HSV-1. Despite being on Acyclovir, the patient did not show signs of improvement. Consequently, a CSF sample was obtained and sent for next-generation sequencing (NGS), which returned a positive result for Parechovirus. In this presented case, the patient exhibited symptoms of an unknown infectious cause. The utilization of NGS and metagenomic analysis helped identify Parechovirus as the primary pathogen present, in addition to other concurrent pathogens. This comprehensive approach facilitated a thorough assessment of the underlying infection and guided targeted treatment. In conclusion, the application of NGS techniques and metagenomic analysis proved instrumental in identifying the root cause of the infection.
Pharmacological or genetic inhibition of LTCC promotes cardiomyocyte proliferation through inhibition of calcineurin activity.
Authors: Devilée Lynn , Miller Jessica , Reid Janice , Salama Abou Bakr , OU Qinghui , Jamal Madiha , Nong Yibing , Andres Douglas , Satin Jonathan , Mohamed Tamer , Hudson James , Aboulesia Riham 
Published: November 2023

Abstract

Cardiomyocytes (CMs) lost during ischemic cardiac injury cannot be replaced due to their limited proliferative capacity, which leads to progressive heart failure. Calcium (Ca2+) is an important signal transducer that regulates key cellular processes, but its role in regulating CM proliferation is incompletely understood. A drug screen targeting proteins involved in CM calcium cycling in human embryonic stem cell-derived cardiac organoids (hCOs) revealed that only the inhibition of L-Type Calcium Channel (LTCC), but not other Ca2+ regulatory proteins (SERCA or RYR), induced the CM cell cycle. Furthermore, overexpression of Ras-related associated with Diabetes (RRAD), an endogenous inhibitor of LTCC, induced CM cell cycle activity in vitro, in human cardiac slices, and in vivo. Mechanistically, LTCC inhibition by RRAD induces the cell cycle in CMs by modulating calcineurin activity and translocating Hoxb13 to the CM nucleus. Together, this represents a robust pathway for regenerative strategies.
NCMPy: A modelling software for Neutrosophic Cognitive Maps (NCMs) based on Python package
Authors: Kandasamy Ilanthenral , Arumugam Divakar , Rathore Aryan , Arun Ateeth , Jain Manan , B Vasantha . W. , Smarandache Florentin 
Published: November 2023

Abstract
Cognitive Maps are a vital tool that can be used for knowledge representation and reasoning. Fuzzy Cognitive Maps (FCMs) are popular soft computing techniques used to model large and complex systems, and they can aid in explainable AI. FCMs, however, cannot model the indeterminacy that arises in a system due to various uncertainties. Neutrosophic Cognitive Maps (NCMs), upgraded FCMs that could model indeterminacy, was introduced to address this issue. NCMs are a generalization of FCMs, a field of cognitive science firmly based on neural networks. NCMs have been used to solve a wide range of problems. NCMs were introduced in 2002, and even after 20 years, NCMs do not have any supportive software or package, toolbox, or visualization software like FCMs. The main reason for the absence of dedicated software is due to the indeterminacy concept ‘ I ’ and how it has to be handled. This paper presents the dedicated Python package created for handling the functioning of NCMs. The modelling software presented 1 in this paper aids in visualizing the NCMs as a signed digraph with indeter-minacy that is directed signed neutrosophic graph. This package implements a sample case study using NCMs.
Fluorescent Reporters Give New Insights Into Antibiotics-induced Mistranslation
Authors: Hinnu Mariliis , Putrinš Marta , Kogermann Karin , Kaldalu Niilo , Tenson Tanel 
Published: November 2023

Abstract
We developed a reporter system based on simultaneous expression of two fluorescent proteins: GFP as a reporter of the capacity of protein synthesis and mutated mScarlet-I as a reporter of translational errors. Because of the unique stop codons or frameshift mutations introduced into the mScarlet-I gene, red fluorescence was produced only after a mistranslation event. These reporters allowed us to estimate mistranslation at a single cell level using either flow cytometry or fluorescence microscopy. We found that laboratory strains of Escherichia coli are more prone to mistranslation compared to the clinical isolates. As relevant for uropathogenic E. coli, growth in human urine elevated translational frameshifting compared to standard laboratory media, whereas different standard media had a small effect on translational fidelity.
Antibiotic-induced mistranslation was studied by using amikacin (aminoglycoside family) and azithromycin (macrolide family). Bactericidal amikacin induced preferably stop-codon readthrough at a moderate level. Bacteriostatic azithromycin on the other hand induced both frameshifting and stop-codon readthrough at much higher level. Single cell analysis revealed that fluorescent reporter-protein signal can be lost due to leakage from a fraction of bacteria in the presence of antibiotics, demonstrating the complexity of the antimicrobial activity.