bluuebunny/crossref_metadata_2025_split huggingface dataset:
Potential of Plant-derived Exosome-like Nanoparticles from Physalis peruviana Fruit for Human Dermal Fibroblast Regeneration and Remodeling
Authors: Natania Filia , Iriawati Iriawati , Ayuningtyas Fitria Dwi , Barlian Anggraini 
Published: January 2024

Aim:
This research aimed to study the potential of PDEN from P. peruviana fruits
(PENC) for regenerating and remodeling HDF.

Background:
Large wounds are dangerous and require prompt and effective healing. Various efforts
have been undertaken, but have been somewhat ineffective. Plant-derived exosome-like nanoparticles
(PDEN) are easily sampled, relatively cost-effective, exhibit high yields, and are nonimmunogenic.

Objective:
The objective of the study was to isolate and characterize PDEN from Physalis peruviana
(PENC), and determine PENC’s internalization and toxicity on HDF cells, PENC's ability to regenerate
HDF (proliferation and migration), and PENC ability’s to remodel HDF (collagen I and
MMP-1 production).

Methods:
PENC was isolated using gradual filtration and centrifugation, followed by sedimentation
using PEG6000. Characterization was done using a particle size analyzer, zeta potential analyzer,
TEM, and BCA assay. Internalization was done using PKH67 staining. Toxicity and proliferation
assays were conducted using MTT assay; meanwhile, migration assay was carried out by employing
the scratch assay. Collagen I production was performed using immunocytochemistry and MMP-1
production was conducted using ELISA.

Results:
MTT assay showed a PENC concentration of 2.5 until 500 μg/mL and being non-toxic to
cells. PENC has been found to induce cell proliferation in 1, 3, 5, and 7 days. PENC at a concentration
of 2.5, 5, and 7.5 μg/mL, also accelerated HDF migration using the scratch assay in two days.
In remodeling, PENC upregulated collagen-1 expression from day 7 to 14 compared to control.
MMP-1 declined from day 2 to 7 in every PENC concentration and increased on day 14. Overall,
PENC at concentrations of 2.5, 5, and 7.5 μg/mL induced HDF proliferation and migration, upregulated
collagen I production, and decreased MMP-1 levels.

Conclusion:
Isolated PENC was 190-220 nm in size, circular, covered with membrane, and its zeta
potential was -6.7 mV; it could also be stored at 4°C for up to 2 weeks in aqua bidest. Protein concentration
ranged between 170-1,395 μg/mL. Using PKH67, PENC could enter HDF within 6 hours.
PENC was non-toxic up to a concentration of 500 μg/mL. Using MTT and scratch assay, PENC was
found to elevate HDF proliferation and migration, and reorganize actin. Using immunocytochemistry,
collagen I was upregulated by PENC, whereas MMP-1 concentration was reduced.
Novel Image Denoising Techniques Using AFMF
Authors: Talbi Mourad , Nasraoui Brahim 
Published: January 2024

Background:
In this paper, we have proposed a new image-denoising approach, which
is a hybrid technique using the self-organizing migration algorithm (SOMA) and adaptive frequency
median filter (AFMF).

Materials and Methods:
The first step in this approach consists of applying (AFMF) to the noisy
image in order to have the first version of the denoised image. This first version of the denoised
image is considered a clean image, which is then used as an input of an image-denoising system
based on SOMA. This denoising system is then applied for denoising the noisy image and then a
final version of the denoised image can be obtained. This image denoising system based on SOMA
has two inputs, which are the noisy image and the corresponding clean image. However, we have
available only the noisy image, and for that reason, we have first applied the AFMF to the noisy
image and then obtained the first version of the denoised image as the clean image. In order to
improve this proposed denoising technique, we have replaced the denoising system based on SOMA
with targeted image denoising (TID), which is a more recent denoising approach. The PSNR
(peak-SNR) and SSIM (structural similarity) have been used for evaluating the performance of the
image-denoising techniques proposed in this work.

Results:
The results obtained from the computations of PSNR and SSIM show the performance of
these proposed image-denoising techniques.

Conclusion:
The results obtained from the computations of PSNR and SSIM show that the proposed
image-denoising techniques outperform a number of image-denoising approaches existing
in the literature and used here for our evaluation.
A Systematic Review on the Potential Applications of Theranostic
Nanoparticles in Diabetes and its Associated Complication Diabetic
Neuropathy
Authors: Patangia Uddhav , Bhatta Kalpita , Vig Himangi , Priya Sneh , Wal Ankita , Tyagi Lalit Kumar , Wal Pranay 
Published: January 2024

Background:
Diabetes neuropathy is a frequent ailment that has a substantial impact on patients by increasing the risk of falls and causing discomfort. The lower extremities are where diabetic neuropathy patients first feel pain. This discomfort could seem like a pinprick, an electric shock, or something else.

Objective:
Here, we give a comprehensive overview of this quickly developing theranostic appli-cation that includes all relevant imaging, diagnostic, therapeutic, and monitoring elements for the management of diabetes and diabetes neuropathy.

Methods:
The data for the current study was gathered by searching PubMed and Google Scholar. Several research and review publications from various publishers, including Springer Nature, Bentham Science, PLOS one, MDPI, and ACS Publishing Centre, were evaluated to compile the data.

Result:
Recent developments in theranostics have shown promise as alternate management ap-proaches for diabetes and ailments linked to diabetes. Numerous nanotechnology-built biosen-sors, including multiwalled carbon nanotubes, copper nanowires, zinc oxide tetrapods, and nano-particle-embedded contact lenses, offer benefits in monitoring diabetic neuropathy.

Conclusion:
The potency, usability, and dependability of insulin substitutes have been demon-strated by a variety of innovative methods for the management of diabetes, which includes nano-technology approaches using Gene-Based Nanoparticles (siRNA), Liposomes, Exo-somes/Extracellular Vesicles, Neuromodulation, and Inhalable Nanoparticles. Over the past few years, the development of various theranostic nanoparticles for Diabetic neuropathy has experi-enced an unprecedented expansion. Even though much work needs to be done to precisely evalu-ate the genuine benefits provided by these particles, such as issues with nanotoxicity, theranostic nanoparticles will have a significant impact on the field of nanomedicine.
Nanotechnology in Drug Delivery: Overcoming Poor Solubility Challenges
through Nanoformulations
Authors: Chaudhary Atul , Shambhakar Sharda 
Published: January 2024

:
The pharmaceutical sector continues to face difficulties with poorly soluble drug solubility. Insufficiently soluble drugs have low bioavailability, and their effectiveness is frequently
affected. Numerous approaches have been developed in response to this challenge, including using various dosage forms, solid dispersions, nano-suspensions, self-emulsifying drug delivery
systems, and cyclodextrin complexes. By improving drug dissolving, decreasing drug particle
size, and increasing drug dispersion, these dosage forms seek to increase drug solubility. Nanotechnology is one of the latest advances that has the potential to revolutionize the delivery of
drugs and significantly improve the solubility of drugs that are now poorly soluble. Since they
have a larger surface area and can pass through biological barriers, nanoparticles are particularly
well suited for the delivery of drugs. These technologies can potentially enable the development
of more effective and efficient drug formulations for the treatment of various diseases. In addition, the review highlights recent advances in the field, including emerging technologies such as
nanotechnology, which can revolutionize drug delivery and significantly improve the solubility of
poorly soluble drugs with their potential applications.
Diagnosis and Management System of Healthcare Resources for Pulmonary
Cardio-vascular Diseases Based on Supervised Machine Learning
Authors: Mbida Mohamed 
Published: January 2024

Introduction:
The detection and management of diseases have always been
critical and challenging tasks for healthcare professionals. This necessitates expensive
human and material resources, resulting in prolonged treatment processes. In medicine,
misdiagnosis and mismanagement can significantly contribute to mistreatment and resource
loss. However, machine learning (ML) techniques have demonstrated the potential
to surpass standard patient treatment procedures, aiding healthcare professionals in
better disease management.

Methods:
In this project, the focus is on smart auscultation systems and resource management,
employing Random Forest Regression (RFR). This system collects patients'
physiological values (specifically, photoplethysmography techniques: PPG) as input and
provides disease detection, treatment protocols, and staff assignments with greater precision.
The aim is to enable early disease detection and shorten both staff and disease
treatment durations.

Result:
Additionally, this system allows for a general diagnosis of the patient's condition,
swiftly transitioning to a specific one if the initial auscultation detects a suspicious disease.

Conclusion:
Compared to the conventional system, it offers quicker diagnoses and satisfactory
real-time patient sorting.
Evaluation of a Computer-Aided Clinical Decision Support System for Point-of-Care Use in Low-Resource Primary Care Settings: Acceptability Evaluation Study
Authors: Tegenaw Geletaw Sahle , Sori Demisew Amenu , Teklemariam Girum Ketema , Verbeke Frank , Cornelis Jan , Jansen Bart 
Published: January 2024

Background
A clinical decision support system (CDSS) based on the logic and philosophy of clinical pathways is critical for managing the quality of health care and for standardizing care processes. Using such a system at a point-of-care setting is becoming more frequent these days. However, in a low-resource setting (LRS), such systems are frequently overlooked.

Objective
The purpose of the study was to evaluate the user acceptance of a CDSS in LRSs.

Methods
The CDSS evaluation was carried out at the Jimma Health Center and the Jimma Higher Two Health Center, Jimma, Ethiopia. The evaluation was based on 22 parameters organized into 6 categories: ease of use, system quality, information quality, decision changes, process changes, and user acceptance. A Mann-Whitney U test was used to investigate whether the difference between the 2 health centers was significant (2-tailed, 95% CI; α=.05). Pearson correlation and partial least squares structural equation modeling (PLS-SEM) was used to identify the relationship and factors influencing the overall acceptance of the CDSS in an LRS.

Results
On the basis of 116 antenatal care, pregnant patient care, and postnatal care cases, 73 CDSS evaluation responses were recorded. We found that the 2 health centers did not differ significantly on 16 evaluation parameters. We did, however, detect a statistically significant difference in 6 parameters (P<.05). PLS-SEM results showed that the coefficient of determination, R2, of perceived user acceptance was 0.703. More precisely, the perceived ease of use (β=.015, P=.91) and information quality (β=.149, P=.25) had no positive effect on CDSS acceptance but, rather, on the system quality and perceived benefits of the CDSS, with P<.05 and β=.321 and β=.486, respectively. Furthermore, the perceived ease of use was influenced by information quality and system quality, with an R2 value of 0.479, indicating that the influence of information quality on the ease of use is significant but the influence of system quality on the ease of use is not, with β=.678 (P<.05) and β=.021(P=.89), respectively. Moreover, the influence of decision changes (β=.374, P<.05) and process changes (β=.749, P<.05) both was significant on perceived benefits (R2=0.983).

Conclusions
This study concludes that users are more likely to accept and use a CDSS at the point of care when it is easy to grasp the perceived benefits and system quality in terms of health care professionals’ needs. We believe that the CDSS acceptance model developed in this study reveals specific factors and variables that constitute a step toward the effective adoption and deployment of a CDSS in LRSs.
Enhancement of Phosphorus Sorption onto Peanut shell by Means of Aluminum and Iron Oxide Coatings
Authors: Ali Hazhar Jalal , Rasheed Muhammed Saeed , Hawramy Omran A , Saeed Aya Muhammed 
Published: January 2024

Phosphorus serves as a crucial nutrient for the organisms. Still, the discharge of high levels of phosphate concentrations into limited aquatic environments leads to the phenomenon known as eutrophication, which subsequently leads to the degradation of the overall water quality. In this study the capacity of the peanut shell, Al-coated and Fe-coated is determined in relating by adding 10, 20, and 30, 40 mg P L-1 as (KH2PO4) to 1.0 g of each sample and shaking for 2, 6, 12, and 24 h and at pH ranged between 4.6, 5.2, 6.3 and 7.8. At the end of each period, the suspension was filtered and analyzed which presents the concentration of equilibrium P. The maximum P adsorption of 28.9±0.07 and 50.6±0.49% was recorded for 24 h of incubation and at pH (4.6) with an Al-coated peanut shell respectively. The findings of this study demonstrated that the adsorption of phosphorus (P) increased as the duration of incubation increased. At the same time, it decreased with a decrease in the pH of the solution. Furthermore, the outcomes indicated that the Freundlich model provided the best fit for the data, based on higher R2 values ranging from 0.9867 to 0.9938, in comparison to the range of 0.9659 to 0.9904 observed for the Longmuir model. These results suggested that peanut shells coated with Al can be used to remove high amounts of P in the solution. Also, the removal resulted from the physical adsorption of P rather than a chemical reaction.
Extrapolation of traditional views on women in China
Authors: Chen S. 
Published: January 2024

The purpose of the study, the results of which are briefly presented in this article, was to assess the influence of traditional Chinese thought on women.The following research methods were chosen: historical scientific method, abstract-logical scientific method, formal-legal scientific method, comparative analysis method, scientific objectivism method.Briefly, the results of the study can be presented as follows: practices such as meditation, wushu, qigong have a direct impact on women around the world due to their use for exclusively health purposes. In this sense, it is appropriate to assume that in this way Chinese philosophy can influence the worldview of people (in particular, women). At the same time, from the point of view of Chinese philosophy, a woman plays a subordinate role in relation to a man.The author makes the following conclusions. In our opinion, one of the ways that can adapt traditional Chinese teachings to the realities of today should be the idea of using a woman not only as a homemaker, but also as a manager, negotiator, manager (transformation concepts of Taoism). Thus, the ability to negotiate, based on modern scientific psychology, is inherent in people with an androgynous type of thinking. And in this sense, men should learn communication skills, first of all, from women. This may be relevant not only from a moral point of view, but also from the point of view of the development of modern economics. Moreover, this idea is quite applicable to other countries, including Russia.
Screening the health status of people working in a university
Authors: Aimo Alberto , Vergaro Giuseppe , De Rosis Sabina , Giannoni Alberto , Damone Anna Luce , Innocenti Alessandro , Marcheschi Paolo , Camerini Lara , Panichella Giorgia , Morfino Paolo , Passino Claudio , Emdin Michele , Nuti Sabina 
Published: January 2024

Background
We aimed to evaluate the physical and mental well being of people working in our academic institution.

Methods
This online survey targeted professors (n = 108), researchers (n = 78), technical and administrative staff (n = 279) working in the Scuola Superiore Sant’Anna (Pisa, Italy). Twenty-four multiple-choice questions explored the physical and mental health status, the main cardiovascular risk factors and levels of physical activity, the risk of cancer, and eating and drinking habits.

Results
Over 1 week, 112 participants out of 465 (24%) completed the survey [69% women, median age 43 years (interquartile range 33–53)]. The physical and mental health were judged as ‘poor’ by 5% and 13%. Many individuals had at least one cardiovascular risk factor (diabetes, 4%; hypertension, 10%; family history of coronary artery disease before 40 years, 21%; hypercholesterolemia, 24%; current or former smoking habit, 39%), and 6% had all of them. Many participants were rather sedentary: for example, 44% never or hardly ever walked at a quick pace for ≥20 min. As for eating and drinking habits, 36% ate sweets five or six times a week or every day, 15% drank beer and/or wine at least five or six times a week, and 5% drank spirits three or four times a week.

Conclusions
A small but not negligeable proportion of responders complained of ‘poor’ health, and 65% had at least one cardiovascular risk factor. The global levels of physical activity and eating and drinking habits were globally suboptimal. Educational and screening activities to improve the wellbeing of people working in academia are advisable.
Supernumerary teeth in the premaxillary region: its effects on the eruption and occlusion of the permanent incisors
Authors: Nik-Hussein Nik Noriah 
Published: January 2024

Abstract
The presence of supernumerary teeth in the premaxillary region may cause a variety of pathological effects. This study was carried out to determine the various aspects of supernumerary teeth in the premaxillary region, particularly the effects of the supernumerary teeth on the permanent incisors and surrounding tissues. Approximately 20 percent of the patients (n=49) with supernumerary teeth did not present with any abnormality. A high proportion of patients (37.9 percent) had delayed or failure of eruption of permanent teeth and 24.1 percent had rotation or displacement of permanent teeth. Other effects observed were median diastema and cystic changes around the unerupted supernumerary tooth. The high proportion of pathological effects seen showed that early diagnosis of the anomaly is important to intercept damage to the adjacent normal teeth and surrounding tissues. However, no cases of root resorption of the permanent teeth due to the presence of supernumeraries were observed.
Psychiatric nosological historiography - Part II: psychopharmacology and somatogenic perspectives
Authors: Gomes Marleide de Mota , Mendlowicz Mauro Vitor , Nardi Antonio Egidio 
Published: January 2024

Introduction: The history of psychiatry encompasses the evolving concepts about the relationship between body and mind and also of the definiton of normality, which depend on the knowledge and customs of different times and places. For a better understanding of this journey, this study privileged the presentation of the main influential figures on the construction of psychiatric nosology and classifications mainly unfolded on a descriptive or causal basis, from psychics or somatics driving, since the Western Renaissance. This article, the second in a two-part series, mainly discusses the importance of psychopharmacology for a better understanding of mental disorders and their classifications. Part one is a preamble to the historical development of the new nosography and psychopharmacology. Method: Narrative review based on secondary sources. Results: The current article illustrates how the understanding of the pathophysiological mechanisms underlying mental illness improves, mainly employing the psychopharmacology that may lead to the reclassification of certain mental disorders. This natural reductionism view of the sciences must be in cooperation with an integrative understanding of the human being, as is customary in the humanities. Conclusion: The study of psychiatric nosohistoriography helps to understand the conceptual evolution of mental illnesses and the most recent importance of psychopharmacology for this.
Harmonizing Loss Accounting with Local Cultural and Religious Principles
Authors: Mohamad Anwar Thalib , Paputungan Vindi , Monantun Widy Pratiwi , Ismail Ulvarien , Damiti Fatmawaty 
Published: January 2024

This research aims to construct loss accounting practices by "binthe biluhuta" sellers based on local wisdom and religious values. This study uses a spiritual paradigm with an Islamic ethnomethodological approach. This approach develops modern ethnomethodology under a secular (interpretive) paradigm. The author conducted observations and interviews with residents to obtain local cultural data. The data obtained was validated using the source triangulation method. The study found that sharing, among others, is a seller's way of avoiding losses. In Gorontalo's Islamic culture, elders often convey these values through advice dilla bo ilaato binthe wawu pale—the meaning of the family statement. The results of this study indicate that the loss accounting implemented by binthe biluhuta sellers is not limited to material things (money) but conditions with local cultural values and faith in the Creator. The theoretical implication of the results of this study is that local wisdom contained in loss accounting implemented by binthe biluhuta sellers can be combined with loss accounting theory to make it more holistic. The concept of loss accounting by binthe biluhuta can be used by sellers with a materialist, humanist, and religious spirit when building a business.
Manifestasi Qur’an Surat Al-Ahqaf (13-14) pada Upaya Membangun Perilaku Istiqomah pada Proses Menghafal Al-Qur’an di SD Takhassus Al-Qur’an Wonosobo
Authors: Muhammad Khasib Amin Murtadlo  , Nasokah  , Munawaroh Hidayatu 
Published: January 2024

Sebagai penghafal Al-Qur’an memiliki sifat istiqomah adalah sebagai sebuah keharusan. Dan pada prosesnya ada beberapa kendala yang di alami dalam perwujudan sikap istiqomah dalam menghafal. Tujuan dari penelitian ini adalah untuk Mengetahui bagaimana perilaku istiqomah pada proses menghafal al-Qur’an, serta faktor penghambat dan pendukung, dan bagaimana manifestasi QS: 46 (13-14) pada upaya membangun perilaku istiqomah pada proses menghafal al-Qur’an di SD Takhassus Al-Qur’an Wonosobo. Penelitian ini adalah studi tentang latar belakang situasi yang dirinci secara intensif dan interaksi individu, sosial, dan kelompoknya.. Hasil penelitian ini menunjukan Manifestasi ayat dalam QS: 46 (13-14) dapat meningkatkan semangat anak agar tetap istiqomah dalam menghafal al-Qur’an dengan didasari dan didukung oleh peraturan sekolah dan asrama serta asatidz dan pembina kamar yang selalu mendampingi dan menjadi juru kunci kesuksesan dalam pengamalan ayat ayat al-Qur’an agar bisa di amalkan kepada anak dalam proses menghafal al-Qur’an.