bluuebunny/crossref_metadata_2025_split huggingface dataset:
Dietary total antioxidant capacity and risk of prediabetes and diabetes mellitus: a systematic review and dose-response meta-analysis of 170,919 participants
Authors: Li Ruomeng , Shu Long , Zhu Qin , Lu Dan 
Published: February 2025

BackgroundObservational studies have assessed the association between total antioxidant capacity of the diet and risk of diabetes mellitus. However, results from these studies were not entirely consistent. In the current systematic review and dose-response meta-analysis, we aimed to determine the association between dietary total antioxidant capacity (TAC) and the risk of prediabetes and diabetes mellitus.MethodsA systematic literature search of authentic electronic resources including PubMed/Medline, Embase, Scopus, ISI Web of Science and China National Knowledge Infrastructure (CNKI) was carried out to find the relevant articles published up to November 2024. Random-effects or fixed-effects models were used to aggregate the relative risks (RRs) and their 95% confidence intervals (CIs) where appropriate. Heterogeneity across the studies were determined using the Cochran’s Q test and I-square (I2) statistics.ResultsA total of 10 observational studies (five cohort, three case-control and two cross-sectional studies) were included in our meta-analysis. The pooled results indicated that higher dietary TAC was significantly associated with lower risk of prediabetes (RR = 0.58; 95% CI: 0.34–0.97; p = 0.039) and diabetes mellitus (RR = 0.71; 95% CI: 0.58–0.87, p = 0.001). In addition, dose-response analysis showed a linear trend association between dietary TAC and risk of diabetes mellitus (RR = 0.928; 95% CI: 0.842–1.023, pdose-response = 0.131, pnonlinearity = 0.078). Subgroup analyses showed the significant inverse association between dietary TAC and diabetes mellitus in mean age &lt;50 and sample size &lt;5,000 (RR = 0.26, 95% CI: 0.16–0.41, p &lt; 0.001), and there was no evidence of heterogeneity (p = 0.939; I2 = 0.0%). Meanwhile, there was also an inverse association between dietary TAC and diabetes mellitus in Western countries (RR = 0.79; 95% CI: 0.68–0.92, p = 0.003), with less evidence of heterogeneity (p = 0.226; I2 = 36.7%).ConclusionOverall, higher dietary TAC was inversely associated with the risk of prediabetes and diabetes mellitus. Further well-designed prospective studies or randomized controlled trials are needed to validate the present findings.Systematic Review Register(PROSPERO), CRD42024611235.
Treatment of metastatic castration-resistant prostate cancer: review of current evidence and synthesis of expert opinions on radioligand therapy
Authors: Poon Darren M. C. , Cheung William S. K. , Chiu Peter K. F. , Chung Daniel H. S. , Kung John B. T. , Lam Daisy C. M. , Leung Angus K. C. , Ng Anthony C. F. , O’Sullivan Joe M. , Teoh Jeremy Y. C. , Wu Philip Y. , Wu Sam K. K. , Kwong Philip W. K. 
Published: February 2025

BackgroundDespite the boom in the development of cancer management in the last decade, most patients with metastatic prostate cancer (PCa) eventually progress to metastatic castration-resistant PCa (mCRPC) and often require multiple lines of treatment. The treatment landscape of mCRPC has evolved rapidly in recent years, introducing various types of systemic therapies, including taxane-based chemotherapy, androgen receptor pathway inhibitors, bone-targeted radionuclides (e.g., radium-223), immune checkpoint inhibitors, poly(adenosine diphosphate [ADP]-ribose) polymerase (PARP) inhibitors, and radioligand therapies (RLTs) [e.g., a prostate-specific membrane antigen (PSMA) ligand labelled with 177Lu].MethodsTo help clinicians navigate the increasingly complex treatment landscape of mCRPC, this article reviews the evidence on different therapeutic regimens from pivotal trials. In addition, it reports on the results of a questionnaire developed and distributed by the Hong Kong Society of Uro-Oncology (HKSUO), with the aim of collecting the perspectives of specialists experienced in the treatment of advanced PCa in Hong Kong with regard to the clinical application of RLT, primarily [177Lu]Lu-PSMA-617/analogue therapy.ResultsA total of 43 questionnaire respondents (including clinical oncologists, urologists, nuclear medicine specialists, and medical oncologists) voted on 27 consensus questions divided into eight sections. Consensus or strong consensus (correspondingly ≥75% or ≥90% acceptance for an answer option) was reached for 10 questions. Subsequently, a panel of 13 local and overseas experts coordinated by the HKSUO discussed the voting results and provided further insights into certain questions.ConclusionThe literature review, the voting results of the questionnaire, and the expert opinions are expected to facilitate better understanding of recent therapeutic advancements and the role of novel RLTs in the treatment of mCRPC among clinicians.
Enhanced efficacy of immune checkpoint inhibitors combined locoregional therapy and tyrosine kinase inhibitors in the treatment of unresectable hepatocellular carcinoma: A single - center retrospective study
Authors: Bu Junfeng , Li Zihan , Hu Die , Lan Ling , Huang Jiwei , Wang Xin , Li Qiu , Zhou Jin , Zeng Yong 
Published: February 2025

BackgroundUnresectable hepatocellular carcinoma (HCC) presents significant treatment challenges. While locoregional therapies (LT) and tyrosine kinase inhibitors (TKI) offer some benefits, prognosis remains poor. Immune checkpoint inhibitors (ICI) have shown promise in other oncological settings, suggesting potential benefits in HCC treatment regimens.MethodsThis retrospective study analyzed 232 patients diagnosed with unresectable HCC at West China Hospital from January 2019 to December 2023. Patients were categorized into two treatment groups: LT+TKI and LT+TKI+ICI. All patients underwent standardized locoregional treatments and first-line TKIs, with the latter group also receiving ICIs. The primary endpoints measured were overall survival (OS) and progression-free survival (PFS). Survival analysis utilized Kaplan-Meier estimates and Cox regression models.ResultsThe LT+TKI+ICI group demonstrated significantly improved survival outcomes compared to the LT+TKI group. Median OS was 28 ± 3.9 months in the LT+TKI+ICI group versus 21 ± 3.0 months in the LT+TKI group, with corresponding 6-, 12-, and 24-month OS rates of 96.8%, 79.3%, and 59.4% versus 85.8%, 71.5%, and 44.1%, respectively (HR, 0.64; 95% CI, 0.449-0.913; P = 0.014). Median PFS also favored the LT+TKI+ICI group (11 ± 1.1 months vs. 7 ± 0.76 months; HR, 0.60; 95% CI, 0.452-0.805; P&lt;0.001). Multivariable analysis identified LT+TKI, vascular invasion, and metastasis as independent risk factors for poorer survival outcomes.ConclusionsAdding ICI to LT and TKI significantly extends both OS and PFS in patients with unresectable HCC. These findings suggest that integrating ICI into treatment protocols could be beneficial in managing unresectable HCC, particularly for patients with vascular invasion.
Significance of LRFN4 in prognosis and tumor microenvironment of lung adenocarcinoma
Authors: Wang Nana , Cao Shuming , Tan Xiaofeng , Liu Meirong 
Published: February 2025

BackgroundLRFN4 is expressed in various tumors and leukemia cell lines. This study aims to explore the effect of LRFN4 in lung adenocarcinoma (LUAD).MethodsThe data on LUAD patients were collected from the Cancer Genome Atlas and Gene Expression Omnibus database. The expression of LRFN4 in LUAD and LUAD cell lines was analyzed via differential gene analysis, qRT-PCR assay, and Western blotting assay. The correlation of LRFN4 expression with the onset of LUAD were calculated using Pearson correlation analysis. The transcription factors correlated with LRFN4 expression were screened by differential expression analysis and Pearson correlation analysis. Moreover, the effect of LRFN4 on the immune landscape of LUAD was analyzed using CIBERSORT algorithm. The GDSC and CTRP databases were used to analyze the drug sensitivity of hub gene.ResultsLRFN4 was highly expressed in LUAD patients and cells, and LRFN4 expression was correlated with metastasis, pathological stages, and age of LUAD patients. The transcription factors E2F1 and E2F3 could regulate LRFN4 expression by binding upstream of LRFN4. The 8 immune cell infiltration levels were differential between LRFN4high and LRFN4low patients. The ESTIMATEScore and ImmuneScore levels were decreased, the TumorPurity level was elevated, and 6 immune checkpoint expressions were increased in LRFN4high patients. Moreover, LRFN4high patients had inferior prognosis. The mutation rate of TP53, TTN, and MUC6 and the level of TMB were increased in LRFN4high patients. The expressions of TCF3, E2F1, E2F3, and LRFN4 were correlated with the IC50 of multiple drugs.ConclusionLRFN4 may serve as a novel prognostic biomarker for LUAD, shows specific overexpression in LUAD and may be a potential therapeutic target for LUAD patients.
Music listening for psychological well-being in adults with acquired vision impairment: a feasibility randomised controlled trial
Authors: Somani Nurbanu , Street Alexander , Beukes Eldre Wiida , Zhang Jufen , Allen Peter M. 
Published: February 2025

PurposeVision impairment (VI) has a profound impact on mental health and well-being. Music-based interventions, such as active music listening, have potential to induce relaxation, improve mood, and reduce stress. This study investigated the feasibility and acceptability of a supportive self-care music intervention in adults with acquired VI, who ran their listening program independently.MethodsA two-arm, parallel-group, single-blind feasibility randomised controlled trial compared: (1) daily music listening with brief mindfulness instructions and (2) daily music listening alone. The study adhered to the CONSORT extension for pilot and feasibility trials and the music reporting checklist. Feasibility was determined by collecting data on attrition, through recruitment and retention at pre-post and 3-month follow-up, including adherence and fidelity which were determined by participants’ questionnaire and daily log completion, respectively. Acceptability was determined through data capture in the questionnaires. To assess whether the music intervention had an impact on anxiety and depression and stress, the Hospital Anxiety Depression Scale (HADS) and the Perceived Stress Scale (PSS-14) were used.ResultsEighty-one VI participants were randomised to mindful music listening (n = 41) or music listening alone (n = 40), with 85% (n = 69) completing the intervention (post intervention end-point). A rating of ‘highly satisfied’ was given for the intervention by 77% (n = 53) of participants. Feasibility was determined through retention which was 71% at the three-month follow-up, and adherence to the daily log completion, which was low (16%), resulting in insufficient data to assess fidelity to the music listening. HADS and PSS-14 data indicated a reduction in anxiety, depression and stress at post-intervention phase.ConclusionsThe recruitment and retention rates suggest that an efficacy study is feasible. However, adherence to daily log completion was low, resulting in uncertainty regarding the fidelity of the listening conditions. While completing the daily logs was not required in this study, it should be mandatory in future trials.Clinical Trial Registrationhttps://clinicaltrials.gov/study/, identifier NCT05243732.
Carmofur Exhibits Antimicrobial Activity Against Streptococcus pneumoniae
Authors: Lyu Wenting , Zhang Yuqing , Zhang Zhen , Lu Hao 
Published: February 2025

Background/Objectives: Streptococcus pneumoniae (S. pneumoniae) is a major pathogen causing severe infectious diseases, with an escalating issue of antimicrobial resistance that threatens the efficacy of existing antibiotics. Given the challenges in developing traditional antibiotics, drug repurposing strategies offer a novel approach to address the resistance crisis. This study aims to evaluate the antibacterial and anti-biofilm activities of the approved non-antibiotic anticancer drug carmofur against multidrug-resistant S. pneumoniae, and investigate the mechanism of action, and assess therapeutic potential in vivo. Methods/Results: Antimicrobial tests revealed that carmofur exhibited strong antibacterial activity against multidrug-resistant S. pneumoniae strains, with minimum inhibitory concentrations (MICs) ranging from 0.25 to 1 µg/mL. In the biofilm detection experiments, carmofur not only inhibited the formation of biofilms, but also effectively removed biofilms under high concentration conditions. Mechanistic studies showed that carmofur disrupted bacterial membrane permeability and decreased intracellular ATP levels. Molecular docking and dynamics simulation assays indicated that carmofur could stably bind to thymidylate synthase through hydrogen bonding and hydrophobic interactions, thereby exerting antibacterial effects. Meanwhile, carmofur was able to repress the expression of the thyA gene at the mRNA level. In a mouse infection model, the carmofur treatment group showed a reduction of approximately two log levels in bacterial load in lung tissue and blood, a significant decrease in the levels of inflammatory cytokines TNF-α and IL-6, and an improvement in survival rate to 60%. Conclusions: In summary, carmofur demonstrated significant antibacterial and anti-biofilm activities against multidrug-resistant S. pneumoniae and showed good anti-infective effects in vivo, suggesting its potential clinical application as a therapeutic agent against drug-resistant bacteria.
Prevalence of Clostridium perfringens Encoding the netF Toxin Gene in Dogs with Acute and Chronic Gastrointestinal Diseases
Authors: Wessely Victoria , Suchodolski Jan S. , Cavasin João P. , Holz Mara , Busch-Hahn Kathrin , Unterer Stefan 
Published: February 2025

Several recent studies have reported a significantly greater prevalence of Clostridium perfringens encoding the novel pore-forming netF toxin gene in dogs with acute hemorrhagic diarrhea syndrome. However, the presence of netF in other canine diarrheal diseases remains poorly characterized. This retrospective, cross-sectional study aimed to describe the prevalence and abundance of netF-positive C. perfringens in fecal samples from 352 dogs with acute and chronic gastrointestinal diseases. Dogs were divided into five groups: acute hemorrhagic diarrhea syndrome (AHDS), acute diarrhea (AD), chronic enteropathy (CE), exocrine pancreatic insufficiency (EPI), and healthy controls (HCs). The abundances of C. perfringens 16S rRNA, the C. perfringens enterotoxin gene and the C. perfringens netF gene in fecal samples were analyzed by quantitative polymerase chain reaction. In total, 7 of 15 (46.7%) dogs with AHDS, 10 of 75 (13.3%) dogs with AD, 2 of 120 (1.7%) dogs with CE, 1 of 12 (8.3%) dogs with EPI, and 1 of 130 (0.8%) HC dogs tested positive for netF. This study provides further evidence that NetF may be a significant contributor to the etiology of AHDS and potentially to a subset of acute nonhemorrhagic diarrhea cases, while it was only rarely detected in chronic gastrointestinal disease phenotypes.
Les relations tragiques entre vivants et morts à l’aube du théâtre occidental
Authors: Jouanna Jacques 
Published: February 2025

La première tragédie conservée du théâtre occidental a été l’objet d’une révolution philologique au cours du XXe siècle. Cette tragédie est bien une pièce d’Eschyle, mais ce n’est pas les Suppliantes , pièce mythique, comme on le croyait encore au début du XXe siècle par suite de l’importance du chœur ; c’est les Perses , tragédie connue surtout par son aspect politique, la victoire des Grecs contre les Perses lors de la seconde guerre médique, vue du côté des Perses au moment décisif où le chœur angoissé des fidèles du Roi restés à Suse et la Reine qui vient d’avoir un rêve prémonitoire vont apprendre la défaite de l’expédition de son fils Xerxès par la bouche d’un messager et se terminera par le retour lamentable de Xerxès entouré de quelques survivants. Il est procédé dans la présente étude à une relecture de toute la tragédie à partir des relations entre les vivants et les morts, en accordant une place essentielle aux rites qui règlent leurs relations entre eux et leurs relations avec les dieux. Bien loin d’être secondaires, les nécessités du rite constituent le moteur de l’action expliquant l’arrivée de la reine, son départ et son retour, et surtout contribuent au spectacle en permettant l’apparition de Darius mort au centre de la tragédie, puis à la fin de la pièce la déploration de Xerxès et du chœur en l’honneur des morts lors de l’expédition. Une telle étude n’est possible que par une analyse en réseau d’une foule d’indications dramaturgiques incluses dans son texte par l’auteur, qui renseignent soit sur ce qui se passe (indications dramaturgiques contemporaines), soit sur ce qui s’est passé (indications dramaturgiques régressives), soit sur ce qui va se passer (indications dramaturgiques progressives).
Desafios: insights de um aplicativo de saúde e bem-estar
Authors: Pagotto Fernanda , Antunes Carlos , Ramirez Leticia , Barbosa Lívia , Tanizaki Livia , Alves Bárbara Shibuya , Caldeira Patrícia , Tarifa Alexandre , Pimentel Carolina 
Published: February 2025

Os aplicativos de saúde incentivam comportamentos saudáveis ao oferecerem conteúdos acessíveis e comunidades online. Os desafios temáticos foram criados para aumentar a retenção e engajamento. Objetiva-se avaliar engajamento na jornada de saúde e retenção dos usuários de um aplicativo de saúde que participaram de desafios temáticos. Para tanto, procedeu-se à realização de 4 desafios com duração de 14 dias no aplicativo de saúde, que apresentavam aos usuários conteúdos e estimulavam ações como interações em comunidades, acesso aos cardápios, exercícios físicos e meditação. Foram realizadas estatísticas descritivas e testadas hipóteses entre os grupos. A média de usuários inscritos em desafios foi de 1.403 e em torno de 28.548 usuários que não estavam inscritos no mesmo período em média. O primeiro desafio implementado apresentou a maior diferença de retenção (z = 24,27), seguido pelo último desafio implementado (z = 22,31). O terceiro desafio apresentou a terceira maior diferença entre os grupos (z = 20,94) seguido pelo segundo desafio (z = 2,86). Em relação às ações de engajamento, nas interações nas comunidades foi observado que os usuários do desafio apresentaram maior engajamento (M = 105,71; DP = 32,7) do que os que não estavam no desafio (M = 44,16; DP = 16,81). O que permite concluir que os desafios deste aplicativo de saúde mostraram-se eficazes para aumentar a retenção e o engajamento nas ações de interação entre usuários que estão na mesma jornada de temática de saúde quando comparados com os usuários que não participaram dos desafios.
«Red lines» in administration and management of complex systems
Authors: Voronin Albert , Savchenko Alina 
Published: February 2025

The problem of optimizing a control system for an object created to fulfill several purposes is considered. Such a system has limited resources, determined during the administration process, based on the real capabilities of the developer. When optimizing the system, it is necessary to take these restrictions into account without violating them. This explains the presence of so-called «red lines», approaching which is undesirable or completely unacceptable. The optimization problem contains optimization arguments that deliver the extremum to the objective function. The objective function is based on the concept of a nonlinear trade-off scheme, for which the «away from restrictions» principle is satisfied. The optimization problem is solved formally, without the direct participation of the decision maker (DM). We consider an object O, the state of which is determined by a set of values x1,x2,…xn from the admissible region X that make up the vector x={xi}ni=1∈X. An object pursues several goals, the degree of achievement of each of them is expressed by the corresponding criterion yk(k), k ∈[1,…,s]. The criteria form a vector y={yk(x) }si=1∈M. Area M is determined by restrictions ykkmaxkmin obtained during the administration process. This is the analytical expression of «red lines». The optimization problem is to determine the arguments x1,x2,…xn by extremizing the objective function Y[y(x)] Essentially, this function is a scalar convolution of the criteria vector y(x), reflecting the utility function of the decision maker when solving a specific optimization problem. Scalar convolution is the act of composing criteria. A criterion yk(x) is a measure of the quality of functioning of object O in relation to the achievement of the k-th goal. If «more» means «better» then to improve quality this criterion must be maximized. Otherwise, the criterion is minimized. For definiteness, we consider the optimization problem with minimized quality criteria.
Wkład dziewięciu pokoleń rodu Taylorów do polskiej kultury
Authors: Sroka Stanisław Tadeusz 
Published: February 2025

Artykuł opisuje wkład przedstawicieli rodu Taylorów w budowanie kultury polskiej. Wywodząca się ze Szkocji rodzina Taylorów przybyła do Polski w XVII w. prawdopodobnie w poszukiwaniu lepszych warunków życia. Początkowo wyznania kalwińskiego, stopniowo przechodziła na katolicyzm i szybko się polonizowała, a kolejne jej pokolenia wnosiły coraz większy wkład w rozwój kulturalny i społeczny naszego kraju. Swoją obecność jej członkowie początkowo zaznaczyli przede wszystkim w służbie wojskowej, a od szóstego pokolenia także w dziedzinach prawa i ekonomii oraz w naukach ścisłych. Zasłużyli się też w czasach współczesnych, włączając się w przemiany społeczne i demokratyczne po przełomie politycznym 1989 r. w Polsce.
Konflikt tożsamościowy – geneza i charakterystyka zjawiska
Authors: Klimek Jordan 
Published: February 2025

Zestawienie dwóch kategorii teoretycznych, tj. konfliktu i tożsamości, odzwierciedla zjawiska występujące w przestrzeni relacji społecznych, które – choć bywają zauważone „między wierszami” – to do tej pory nie zostały w naukach społecznych jednoznacznie zdefiniowane lub dookreślone. W artykule podjęto zatem próbę charakterystyki zjawiska konfliktu tożsamościowego. W szczególności dotyczy to określenia jego genezy, uwarunkowań, zakresu i konsekwencji. W wyniku krytycznej analizy literatury przedmiotu określono także poziomy konfliktu tożsamościowego. Wnioski wskazują między innymi, że konflikt tożsamościowy wymaga reakcji, czyli w pierwszej kolejności uświadomienia sobie problemu i jego źródła, a następnie ustosunkowania się do wartości kluczowej dla przedmiotu sporu tożsamościowego, tj. rezygnacji lub włączenia pewnych atrybutów tożsamościowych.
Literatura dziecięca jako iskra nadziei na zażegnanie konfliktów plemiennych w Zimbabwe
Authors: Dymel-Trzebiatowska Hanna 
Published: February 2025

W artykule przypomniana jest historia krwawego, plemiennego konfliktu w Zimbabwe o nazwie Gukurahundi (1983–1987) ze szczególnym uwzględnieniem doświadczeń dzieci. Dzieci, które były ofiarami tej wojny, dziś jako dorosłe osoby nadal noszą ją w pamięci, ale również współczesne, najmłodsze pokolenie jest ofiarą obecnych w narodzie reperkusji Gukurahundi w postaci tzw. lingwistycznego ludobójstwa. W kontekście tych wciąż żywych antagonizmów zadane zostało pytanie, czy jedna z nielicznych na rynku zimbabweńskim współczesnych książek obrazkowych dla dzieci My First Book of Shona and Ndebele Words (Moja pierwsza książka ze słowami w shona i ndebele, 2021) stanowi iskrę nadziei na wychowanie nowego pokolenia, które położyłoby kres długoletniej etnicznej polaryzacji.
Drugim z kolejności środkiem zabezpieczającym jest ucieczka
Authors: Szymborski Wiktor 
Published: February 2025

Celem niniejszego szkicu jest zwrócenie uwagi na interesujący sposób walki z zarazą/ czarną śmiercią, który przedsięwzięli dwaj dominikanie z wrocławskiego klasztoru w drugiej połowie XV w. Wedle rozporządzeń dominikańskich konstytucji zakonnicy nie powinni studiować medycyny, ale postępowanie dwóch braci wskazuje, że posiadali oni podstawową wiedzę z zakresu medycyny i znali ówczesne metody zapobiegania zarazie. Zakonnicy otrzymali specjalną zgodę władz zakonnych na opuszczenie konwentu w przypadku pojawienia się zarazy.