bluuebunny/crossref_metadata_2025_split huggingface dataset:
TED (Trazodone Effectiveness in Depression): effectiveness of trazodone extended-release in subjects with unsatisfactory response to SSRIs
Authors: Siwek Marcin , Chrobak Adrian Andrzej , Krupa Anna Julia , Gorostowicz Aleksandra , Gerlich Adrian , Juryk Andrzej , Dudek Dominika 
Published: December 2023

Cel pracyInhibitory wychwytu serotoniny (SSRI) są najczęściej stosowanymi lekami w leczeniu epizodów dużej depresji (major depressive disorder- MDD). Niemniej jednak, około 50% pacjentów z MDD nie osiąga odpowiedzi terapeutycznej w wyniku leczenia SSRI i istnieje niewiele danych dotyczących tego, które leki są skuteczne jako leczenie drugiego rzutu u pacjentów, którzy nie odpowiadają na leczenie SSRI. W niniejszej pracy przeanalizowano dane 79 pacjentów z MDD, aby ocenić efektywność trazodonu XR w grupach pacjentów leczonych de novo oraz tych, u których zmieniono lek na trazodon XR po nieudanej próbie leczenia SSRI.MetodaPomiary przeprowadzono na początkowym etapie oraz w 2., 4., 8. i 12. tygodniu za pomocą narzędzi do oceny nasilenia: depresji (Skala Depresji Montgomery-Åsberg, Krótki Inwentarz Symptomatologii Depresji wypełniany przez pacjenta i klinicystę - główne punkty końcowe badania), efektywności terapeutycznej (Skala Ogólnego Wrażenia Klinicznego), anhedonii (Skala Przyjemności Snaith-Hamilton), lęku (Skala Lęku Hamiltona), bezsenności (Ateńska Skala Bezsenności), funkcjonowania psychospołecznego (Skala Niepełnosprawności Sheehana) i funkcjonowania seksualnego (Kwestionariusz Funkcji Seksualnych u Kobiet / Międzynarodowy Indeks Funkcji Erekcji u mężczyzn). Poziomy odpowiedzi na leczenie i remisji były w dużej mierze podobne w obu badanych grupach.WynikiWyniki wskazały, że efektywność trazodonu XR w leczeniu pacjentów z MDD, którzy nie reagowali na SSRI podawane jako leczenie pierwszego rzutu w danym epizodzie depresyjnym, była porównywalna do tej obserwowanej u pacjentów leczonych de novo. Ponadto, trazodon XR efektywnie redukował nasilenie depresji, lęku, bezsenności, anhedonię i poprawiał funkcjonowanie psychospołeczne (w obu grupach).WnioskiDodatkowo, trazodon XR jako leczenie drugiego rzutu poprawiał funkcje seksualne u mężczyzn, którzy wcześniej byli leczeni SSRI.
Weak Signal Asymptotics for Sequentially Randomized Experiments
Authors: Kuang Xu , Wager Stefan 
Published: December 2023

We use the lens of weak signal asymptotics to study a class of sequentially randomized experiments, including those that arise in solving multiarmed bandit problems. In an experiment with n time steps, we let the mean reward gaps between actions scale to the order [Formula: see text] to preserve the difficulty of the learning task as n grows. In this regime, we show that the sample paths of a class of sequentially randomized experiments—adapted to this scaling regime and with arm selection probabilities that vary continuously with state—converge weakly to a diffusion limit, given as the solution to a stochastic differential equation. The diffusion limit enables us to derive refined, instance-specific characterization of stochastic dynamics and to obtain several insights on the regret and belief evolution of a number of sequential experiments including Thompson sampling (but not upper-confidence bound, which does not satisfy our continuity assumption). We show that all sequential experiments whose randomization probabilities have a Lipschitz-continuous dependence on the observed data suffer from suboptimal regret performance when the reward gaps are relatively large. Conversely, we find that a version of Thompson sampling with an asymptotically uninformative prior variance achieves near-optimal instance-specific regret scaling, including with large reward gaps, but these good regret properties come at the cost of highly unstable posterior beliefs. This paper was accepted by Baris Ata, stochastic models and simulation. Supplemental Material: The data and online appendix are available at https://doi.org/10.1287/mnsc.2023.4964 .
Quantitative Convergence for Displacement Monotone Mean Field Games with Controlled Volatility
Authors: Jackson Joe , Tangpi Ludovic 
Published: December 2023

We study the convergence problem for mean field games with common noise and controlled volatility. We adopt the strategy recently put forth by Laurière and the second author, using the maximum principle to recast the convergence problem as a question of “forward-backward propagation of chaos” (i.e., (conditional) propagation of chaos for systems of particles evolving forward and backward in time). Our main results show that displacement monotonicity can be used to obtain this propagation of chaos, which leads to quantitative convergence results for open-loop Nash equilibria for a class of mean field games. Our results seem to be the first (quantitative or qualitative) that apply to games in which the common noise is controlled. The proofs are relatively simple and rely on a well-known technique for proving wellposedness of forward-backward stochastic differential equations, which is combined with displacement monotonicity in a novel way. To demonstrate the flexibility of the approach, we also use the same arguments to obtain convergence results for a class of infinite horizon discounted mean field games. Funding: J. Jackson is supported by the National Science Foundation [Grant DGE1610403]. L. Tangpi is partially supported by the National Science Foundation [Grants DMS-2005832 and DMS-2143861].
Engaging knowledge users in Canadian knowledge mobilisation research: a scoping review of research in education
Authors: Sengalrayan Bernadine , Harvey Blane 
Published: December 2023

Background:This study examines the engagement of knowledge users in knowledge mobilisation (KMb) research on Canadian K-12 teaching and education policy. Research on and around KMb has grown in the decade since this field was first assessed comprehensively. Thus, it is timely to re-evaluate if current knowledge producer-user relationships in KMb research feature the mediating variables or recursive elements promulgated as best practices in KMb research.
Methods:A scoping review was conducted to identify the profile of knowledge users, map the engagement of knowledge users, and account for any changes to their roles in the research process since 2008. Twenty-eight relevant studies were identified. Contextual data and frequency of engagement with knowledge users were collected and analysed.
Findings:Findings indicate that a diverse group of knowledge users are engaged in KMb research and draws on knowledge from various disciplines. A majority of the studies reported that knowledge users were engaged in at least two stages of their research process, with them most frequently engaged during the search and data collection phase of the research process.
Discussion and conclusion:There has been an encouraging effort in building iterative producer-user connections with knowledge users being engaged, often repeatedly, across different phases of the research process. This indicates an increasingly collaborative model of soliciting user insights on the development and diffusion of research evidence. The review sets the foundation for potential future research on producer-user engagement and provides insights applicable beyond the Canadian K-12 education system.
Laser micro-machining and damage testing of rounded shadow cone blockers on silica glass for arresting laser damage growth by redirection of light
Authors: Browar Allison E. M. , Bass Isaac , Guss Gabe , Vickers Jim , Norton Mary , Carr Christopher Wren , Feigenbaum Eyal 
Published: December 2023

Structured conical blockers manufactured on optical input surfaces are being used to shadow, and thereby, arrest growth of exit surface damage on large optics for applications in high-energy laser systems to extend their lifetime usage. However, as the size of the Shadow Cone Blocker (SCB) is increased, the deflected light must be carefully managed to prevent consequential damage from downstream intensification. Here, we design and fabricate a distinct input SCB geometry to alleviate this problem, enabling larger damage site mitigation. The demonstrated ∼1 mm diameter SCB was manufactured with a convergent approach using a CO2 pulsed laser ablative scanning sequence on a fused silica window. The SCB design was refined to maximize resistance to both input and exit surface damage initiations on 1 cm thick fused silica windows when exposed to 351 nm irradiation and validated with laser damage testing. The design showed to prevent damage onset to the exit surface for incident fluences on the SCB of 10.7 ± 1.3 J·cm-2 and is resistant to damage on the input surface exceeding 30 J·cm-2 input fluence.
Spatiotemporal electric-field characterization of synthesized light transients
Authors: Mamaikin Mikhail , Ridente Enrico , Krausz Ferenc , Karpowicz Nicholas 
Published: December 2023

The versatile manipulation of electron motion on the atomic scale calls
for the shaping of the electric field evolution of light within a
single cycle. The super-octave bandwidth required for this task
dramatically increases the probability of formation of spatio-temporal
distortions. As a result, the accuracy of physical observables can be
extremely compromised by spatial averaging unless the complete
spatio-temporal field information is known. Here, we apply spatially
resolved electro-optic sampling to record three-dimensional
electric-field structure of a sub-cycle synthesized light transient
carrying wavelengths from 700 to 2700 nm. We show an in-depth
picture of the field synthesis process, disclosing how temporal,
spectral, and global-phase properties of the synthesized pulse vary
across space, including the propagation direction around the focal
point where the transient is generated.
“It’s very saddening, you keep on wondering when the symptoms will be over”: A qualitative study exploring the long-term chikungunya disease impact on daily life and well-being, 6 years after disease onset
Authors: Doran Churnalisa , Duits Ashley , Tami Adriana , Gerstenbluth Izzy , Bailey Ajay 
Published: December 2023

Background
Long-term chikungunya is a mosquito-borne disease, characterized by disabling rheumatic symptoms persisting for years, after infection with the chikungunya virus. Previous studies focused on assessing the well-being of affected individuals from a quantitative perspective using generic instruments, and have reported physical and psychological impairment. However, a common critique is that generic instrument’s structured responses and pre-defined health domains selected by health professionals, may not capture the full extent of well-being impairment experienced by patients. This study aimed to explore in-depth to which extent long-term chikungunya disease impacts daily living and the physical, psychological, and social well-being from the experiences and perspective of affected individuals.

Methodology/Principal findings
Using open-ended questions, in-depth interviews were conducted with 20 purposively selected individuals with long-term chikungunya disease, in Curaçao. Interview audio-recordings were transcribed verbatim. The data were thematically analyzed. Living with persistent rheumatic symptoms affected the participant’s daily living and well-being in several ways: experience of physical impact (restricted physical functioning and limitations in activities of daily life); experience of psychological impact (altered emotional state, fear of walking and running, psychosocial aspects of footwear adaptations, and uncertainty about disease progression and future health); and experience of social impact (social isolation and impaired relational maintenance, social dependency, challenges of social support, at-work productivity loss, and giving up leisure activities after work).

Conclusions/Significance
This study, the first of its kind, indicated that the adverse impact of long-term chikungunya disease is currently underreported. The persistent rheumatic symptoms had a negative effect on functional ability, which in turn impacted broad aspects of daily life and well-being, beyond what is captured by generic instruments. In the view of the findings, physical exercise programs including manual therapy, aerobics, resistance and stretching exercises, and orthopaedic footwear interventions in a multidisciplinary patient-centred approach may improve physical function and subsequently overall well-being.
The effect of light therapy on sleep disorders and psychobehavioral symptoms in patients with Alzheimer’s disease: A meta-analysis
Authors: Zang Lili , Liu Xiaotong , Li Yu , Liu Jiang , Lu Qiuying , Zhang Yue , Meng Qinghui 
Published: December 2023

Background
Although Alzheimer’s disease (AD) mainly affects cognitive function, it is often accompanied by sleep disorders and psychobehavioral symptoms. These symptoms, including depression, agitation, and psychotic symptoms, are prominent hospitalization causes among patients with AD. Currently, relatively more research exists on light therapy for sleep disorders, while those on psychobehavioral symptoms are gradually increasing. However, no consensus exists on these results because of the vulnerability of light therapy to multiple factors, including light intensity and duration. Thus, further research investigating this aspect is warranted.

Objective
To evaluate the efficacy of light therapy in improving sleep disorders and psychobehavioural symptoms in patients with AD.

Methods
In this meta-analysis, relevant literature was searched in Embase, the Clinical Trials Registry, Web of Science, PubMed, and the Cochrane Library up to December 2022. Furthermore, a fixed-effects model was used for data analysis.

Results
Fifteen randomized controlled trials involving 598 patients with AD were included. In the case of sleep disorders, our meta-analysis revealed that light therapy significantly improved sleep efficiency (MD = −2.42, 95% CI = −3.37 to −1.48, p < 0.00001), increased interdaily stability (MD = −0.04, 95% CI = −0.05 to −0.03, p < 0.00001), and reduced intradaily variability (MD = −0.07, 95% CI = −0.10 to −0.05, p < 0.00001). With respect to psychotic behavior, light therapy was found to alleviate depression (MD = −2.55, 95% CI = −2.98 to −2.12, p < 0.00001) as well as reduce agitation (MD = −3.97, 95% CI = −5.09 to −2.84, p < 0.00001) and caregiver burden (MD = −3.57, 95% CI = −5.28 to −1.87, p < 0.00001).

Conclusion
Light therapy leads to significant improvement in sleep and psychobehavioral symptoms and is associated with relatively fewer side effects in patients with AD, indicating its potential as a promising treatment option for AD.
Involvement of an IgE/Mast cell/B cell amplification loop in abdominal aortic aneurysm progression
Authors: Loste Alexia , Clément Marc , Delbosc Sandrine , Guedj Kevin , Sénémaud Jean , Gaston Anh-Thu , Morvan Marion , Even Guillaume , Gautier Grégory , Eggel Alexander , Arock Michel , Procopio Emanuele , Deschildre Catherine , Louedec Liliane , Michel Jean-Baptiste , Deschamps Lydia , Castier Yves , Coscas Raphaël , Alsac Jean-Marc , Launay Pierre , Caligiuri Giuseppina , Nicoletti Antonino , Le Borgne Marie 
Published: December 2023

Aims
IgE type immunoglobulins and their specific effector cells, mast cells (MCs), are associated with abdominal aortic aneurysm (AAA) progression. In parallel, immunoglobulin-producing B cells, organised in tertiary lymphoid organs (TLOs) within the aortic wall, have also been linked to aneurysmal progression. We aimed at investigating the potential role and mechanism linking local MCs, TLO B cells, and IgE production in aneurysmal progression.

Methods and results
Through histological assays conducted on human surgical samples from AAA patients, we uncovered that activated MCs were enriched at sites of unhealed haematomas, due to subclinical aortic wall fissuring, in close proximity to adventitial IgE+ TLO B cells. Remarkably, in vitro the IgEs deriving from these samples enhanced MC production of IL-4, a cytokine which favors IgE class-switching and production by B cells. Finally, the role of MCs in aneurysmal progression was further analysed in vivo in ApoE-/- mice subjected to angiotensin II infusion aneurysm model, through MC-specific depletion after the establishment of dissecting aneurysms. MC-specific depletion improved intramural haematoma healing and reduced aneurysmal progression.

Conclusions
Our data suggest that MC located close to aortic wall fissures are activated by adventitial TLO B cell-produced IgEs and participate to their own activation by providing support for further IgE synthesis through IL-4 production. By preventing prompt repair of aortic subclinical fissures, such a runaway MC activation loop could precipitate aneurysmal progression, suggesting that MC-targeting treatments may represent an interesting adjunctive therapy for reducing AAA progression.
Deletion of the muscle enriched lncRNA Oip5os1 induces atrial dysfunction in male mice with diabetes
Authors: Zhuang Aowen , Tan Yanie , Liu Yingying , Yang Christine , Kiriazis Helen , Grigolon Kyah , Walker Shannen , Bond Simon T. , McMullen Julie R. , Calkin Anna C. , Drew Brian G. 
Published: December 2023

AbstractLong ncRNAs (lncRNAs) have been shown to play a biological and physiological role in various tissues including the heart. We and others have previously established that the lncRNA Oip5os1 (1700020I14Rik, OIP5‐AS1, Cyrano) is enriched in striated muscles, and its deletion in mice leads to defects in both skeletal and cardiac muscle function. In the present study, we investigated the impact of global Oip5os1 deletion on cardiac function in the setting of streptozotocin (STZ)‐induced diabetes. Specifically, we studied male WT and KO mice with or without diabetes for 24 weeks, and phenotyped animals for metabolic and cardiac endpoints. Independent of genotype, diabetes was associated with left ventricular diastolic dysfunction based on a fall in E'/A' ratio. Deletion of Oip5os1 in a setting of diabetes had no significant impact on ventricular function or ventricular weight, but was associated with left atrial dysfunction (reduced fractional shortening) and myopathy which was associated with anesthesia intolerance and premature death in the majority of KO mice tested during cardiac functional assessment. This atrial phenotype was not observed in WT diabetic mice. The most striking molecular difference was a reduction in the metabolic regulator ERRalpha in the atria of KO mice compared with WT mice. There was also a trend for a reduction in Serca2a. These findings highlight Oip5os1 as a gene of interest in aspects of atrial function in the setting of diabetes, highlighting an additional functional role for this lncRNA in cardiac pathological settings.
Dietary supplementation with 1‐kestose induces altered locomotor activity and increased striatal dopamine levels with a change in gut microbiota in male mice
Authors: Altaisaikhan Altanzul , Yoshihara Kazufumi , Hata Tomokazu , Miyata Noriyuki , Asano Yasunari , Suematsu Takafumi , Kadota Yoshihiro , Sudo Nobuyuki 
Published: December 2023

Abstract1‐Kestose (KES), a dietary fiber and prebiotic carbohydrate, benefits various physiological functions. This study aimed to examine whether diets supplemented with KES over three consecutive generations could significantly affect some host physiological aspects, including behavioral phenotypes and gut microbial ecology. Mice that received KES‐supplemented diets for three generations demonstrated increased activity compared with those fed diets lacking KES. Furthermore, the KES group showed increased striatal dopamine (DA) and serotonin (5‐HT) levels. The observed increase in DA levels within the striatum was positively correlated with locomotor activity in the KES group but not in the control (CON) group. The α‐diversities were significantly lower in the KES group compared to the CON group. The three‐dimensional principal coordinate analysis revealed a substantial distinction between the KES and CON groups across each generation. At the genus level, most gut microbiota genera exhibited lower abundances in the KES group than in the CON group, except for Bifidobacteria and Akkermansia. Spearman's rank‐order analysis indicated significant negative correlations between the striatal DA levels and α‐diversity values. These findings suggest that prolonged supplementation with KES may stimulate increased locomotor activity along with elevated striatal DA levels, which are potentially associated with KES‐induced alterations in the gut microbiota.
Life Cycle Assessment
Authors: Kalliala Eija M. , Nousiainen Pertti 
Published: December 2023

Abstract
The aim of this study was to increase the knowledge of environmental impact associated with producing fabrics for hotel textile services. The project was carried out in two parts: studies on hotel textiles and on textile services in three major Scandinavian laundering companies. This paper presents the results of the hotel textile study. The environmental impact was studied by applying the main principles of the life cycle assessment (LCA) methodology. Life-cycle assessments provide useful information on the quantities of energy and resources consumed and emissions associated with production systems. The impact assessment is still under development but some scenarios have been made to describe possible local, regional and global environmental consequences of the system under study. The inventory calculations proved that cotton fibre production consumes about 40% less energy than polyester fibre production. Cotton growing requires, however, huge amounts of water: irrigated amounts vary from 7 to 29 tons per kg of raw cotton fibres. Pesticides and fertilizers used in traditional cotton cultivation have ecotoxic effects in contrast to organic cotton cultivation, where natural alternatives to agrochemicals are used. It could also be concluded that 50/50 CO/PES sheets in hotel use have fewer environmental impacts than 100% CO sheets. This is due to the higher durability as well as lower laundering energy requirements of 50/50 CO/PES sheets.
FIBROUS SYSTEMS WITH PROGRAMMED BIOLOGICAL-ACTIVITY AND THEIR APPLICATION IN MEDICAL PRACTICE
Authors: Skundric Petar , Medovic Adela , Kostic Mirjana 
Published: December 2023

Abstract
An effective two-stage method for obtaining both biologically activated fibres with antibacterial and anaesthetic activity and biologically activated complex fibres -insulin as an artificial store of insulin has been developed. The first stage involves the formation of reactive functional groups by chemical modification, followed by the second stage where the fibres are modified with chemotherapeutic agent solutions. This paper presents the results of obtaining biologically activated fibres with antibacterial and anaesthetic activity as well as an artificial store of insulin in the form of complex ion-exchanged fibreinsulin. The level of immobilisation of the drug in the antibacterial fibre amounts to 140 mg of gentamicin sulphate per 1 g of fibres, in the anaesthetic fibre 180 mg of procaine hydrochloride per 1 g of fibres, and in the fibrous store of insulin 800 mg of insulin per 1 g of fibres.
SURFACE DEGRADATION OF LINEN TEXTILES INDUCED BY LASER TREATMENT: COMPARISON WITH ELECTRON BEAM AND HEAT SOURCE
Authors: Ferrero Franco , Testore Franco , Tonin Claudio , Innocenti Riccardo 
Published: December 2023

Abstract
Surface degradation of linen fabric induced by laser treatment with the aim of reproducing an image was investigated and compared with the degradation induced by an electron beam and a heat source. The results confirm that the brown shades obtained by the laser beam are mainly due to surface tar formation, and that the degradation pattern is similar to that observed by treatment with an electron beam. Surface thermal treatment, however, showed different fibre behaviour.