bluuebunny/crossref_metadata_2025_split huggingface dataset:
Identification of a venetoclax-resistance prognostic signature base on 6-senescence genes and its clinical significance for acute myeloid leukemia
Authors: Ke Peng , Xie Jundan , Xu Ting , Chen Meiyu , Guo Yusha , Wang Ying , Qiu Huiying , Wu Depei , Zeng Zhao , Chen Suning , Bao Xiebing 
Published: November 2023

BackgroundSatisfactory responses can be obtained for acute myeloid leukemia (AML) treated by Venetoclax (VEN)-based therapy. However, there are still quite a few AML patients (AMLs) resistant to VEN, and it is critical to understand whether VEN-resistance is regulated by senescence.MethodsHere, we established and validated a signature for predicting AML prognosis based on VEN resistance-related senescence genes (VRSGs). In this study, 51 senescence genes were identified with VEN-resistance in AML. Using LASSO algorithms and multiple AML cohorts, a VEN-resistance senescence prognostic model (VRSP-M) was developed and validated based on 6-senescence genes.ResultsAccording to the median score of the signature, AMLs were classified into two subtypes. A worse prognosis and more adverse features occurred in the high-risk subtype, including older patients, non-de novo AML, poor cytogenetics, adverse risk of European LeukemiaNet (ELN) 2017 recommendation, and TP53 mutation. Patients in the high-risk subtype were mainly involved in monocyte differentiation, senescence, NADPH oxidases, and PD1 signaling pathway. The model’s risk score was significantly associated with VEN-resistance, immune features, and immunotherapy response in AML. In vitro, the IC50 values of ABT-199 (VEN) rose progressively with increasing expression of G6PD and BAG3 in AML cell lines.ConclusionsThe 6-senescence genes prognostic model has significant meaning for the prediction of VEN-resistance, guiding personalized molecularly targeted therapies, and improving AML prognosis.
Long-term psychological intervention for parents of children with prolonged disorders of consciousness: a pilot study
Authors: Xu Gang , Hao Fuchun , Zhao Weiwei , Zhao Peng , Qiu Jiwen 
Published: November 2023

BackgroundChildren with prolonged disorders of consciousness experience severe intellectual and behavioral disabilities that will last for decades or even a lifetime. Parents generally experience severe anxiety, stress, sadness, or family conflicts, which can lead to abnormal parenting behavior and can, in turn, adversely affect the cognitive, emotional, and behavioral well-being of the children. This causes a serious burden on children, families, and society. Psychological interventions targeting parents using online conversations provide an opportunity to improve the overall well-being of the parents, their children, and the family as a whole.MethodsA total of 13 patients completed the protocol. Six were girls (46.2%), the mean age was 4.5 ± 3.0 years, and the length of time before emergent from minimally consciousness state was 244 ± 235 days. A staff member with psychological counseling qualifications implemented all psychological interventions. Regular online psychological interventions were performed annually before and after discharge. Evaluation data were collected before discharge and at 1 and 3–5 years post-discharge.ResultsWith the extension of intervention time, the Strengths and Difficulties Questionnaire, the Depression Anxiety and Stress Scale-21, and the Parenting Sense of Competence Scale scores showed significant improvement (p &lt; 0.05), while the Revised Scale for Caregiving Self-Efficacy scores did not. With the extension of intervention time, the Strengths and Difficulties Questionnaire (Total Difficulties scores, TD) scores showed significant improvement (p &lt; 0.05), while the scores did not after 1 year compared with before intervention. The Index of Child Care Environment evaluation scores declined significantly (p &lt; 0.05).ConclusionPsychological interventions aimed at the parents of children with prolonged disorders of consciousness performed at least once per year resulted in significant improvements in negative parental emotions, parental self-efficacy, and emotional and behavioral problems in their children. However, the childcare environment continued to decline.
Social Appearance Anxiety Scale: a psychometric investigation and evaluation of the influence of individual characteristics on social appearance anxiety in Brazilian adults who practice physical exercise
Authors: Donofre Giovanna Soler , Campos Juliana Alvares Duarte Bonini , dos Santos Priscila Carvalho , Marôco João , Campos Lucas Arrais , da Silva Wanderson Roberto 
Published: November 2023

IntroductionEvaluating signs of anxiety related to body appearance is becoming increasingly important in contemporary society and, in this sense, the Social Appearance Anxiety Scale (SAAS) seems an interesting alternative of measurement.ObjectivesTo evaluate the psychometric properties of the Portuguese version of the SAAS when applied to Brazilian adults who practice physical exercise and verify the influence of individual characteristics on participants’ social appearance anxiety.MethodsThis was a cross-sectional study conducted online. The participants completed the SAAS and a demographic questionnaire. The psychometric properties of the SAAS one-factor model were evaluated using confirmatory factor analysis. A structural model was built for men and women to verify the influence of individual characteristics of the participants on social appearance anxiety.Results1,495 individuals participated in the study (70.8% women; mean age = 29.5, SD = 8.9 years). The data obtained with the SAAS presented good indicators of validity and reliability for both genders (CFI &gt; 0.97, TLI &gt; 0.97, SRMR = 0.04, α &gt; 0.97, ω &gt; 0.85). For both men and women, greater levels of social appearance anxiety were observed among younger participants, who had a higher body mass index, self-reported an eating disorder, and perceived a change in their body after the onset of the COVID-19 pandemic. For women specifically, higher income and having started physical exercise more recently were associated with greater levels of social appearance anxiety.ConclusionThe findings supported the validity and reliability of the data obtained with the SAAS and revealed that when investigating social appearance anxiety in future research and clinical protocols, specific individual characteristics should be considered.
Improved circuitry and post-processing for interleaved fast-scan cyclic voltammetry and electrophysiology measurements
Authors: Avula Ashwin K. , Goyal Abhinav , Rusheen Aaron E. , Yuen Jason , Dennis Warren O. , Eaker Diane R. , Boesche Joshua B. , Blaha Charles D. , Bennet Kevin E. , Lee Kendall H. , Shin Hojin , Oh Yoonbae 
Published: November 2023

The combination of electrophysiology and electrochemistry acquisition methods using a single carbon fiber microelectrode (CFM) in the brain has enabled more extensive analysis of neurochemical release, neural activity, and animal behavior. Predominantly, analog CMOS (Complementary Metal Oxide Semiconductor) switches are used for these interleaved applications to alternate the CFM output between electrophysiology and electrochemistry acquisition circuitry. However, one underlying issue with analog CMOS switches is the introduction of transient voltage artifacts in recorded electrophysiology signals resulting from CMOS charge injection. These injected artifacts attenuate electrophysiology data and delay reliable signal observation after every switch actuation from electrochemistry acquisition. Previously published attempts at interleaved electrophysiology and electrochemistry were able to recover reliable electrophysiology data within approximately 10–50 ms after switch actuation by employing various high-pass filtering methods to mitigate the observed voltage artifacts. However, high-pass filtering of this nature also attenuates valuable portions of the local-field potential (LFP) frequency range, thus limiting the extent of network-level insights that can be derived from in vivo measurements. This paper proposes a solution to overcome the limitation of charge injection artifacts that affect electrophysiological data while preserving important lower-frequency LFP bands. A voltage follower operational amplifier was integrated before the CMOS switch to increase current flow to the switch and dissipate any injected charge. This hardware addition resulted in a 16.98% decrease in electrophysiology acquisition delay compared to circuitry without a voltage follower. Additionally, single-term exponential modeling was implemented in post-processing to characterize and subtract remaining transient voltage artifacts in recorded electrophysiology data. As a result, electrophysiology data was reliably recovered 3.26 ± 0.22 ms after the beginning of the acquisition period (a 60% decrease from previous studies), while also minimizing LFP attenuation. Through these advancements, coupled electrophysiology and electrochemistry measurements can be conducted at higher scan rates while retaining data integrity for a more comprehensive analysis of neural activity and neurochemical release.
An additively manufactured titanium tilting suture anchor: a biomechanical assessment on human and ovine bone specimens
Authors: Abedi Ali , Pourghazi Farzad , Eslami Maysa , Nabian Mohammad Hossein , Ali Mohammadi Ali Mohammad , Zanjani Leila Oryadi , Farahmand Farzam 
Published: November 2023

IntroductionA novel titanium tilting suture anchor was designed and fabricated using additive manufacturing. The anchor enjoyed a nonsymmetrical structure to facilitate its insertion procedure through a weight-induced tilt, a saw-teeth penetrating edge to provide a strong initial fixation into cancellous bones of various densities, and an appropriate surface texture to enhance the longterm fixation strength through bone ingrowth.MethodsBiomechanical tests were performed on 10 ovine and 10 human cadaveric humeri to examine the insertion procedure and assess the initial fixation strength of the anchor, in comparison with a standard screw-type anchor as control.ResultsThis study indicated a simple yet reliable insertion procedure for the tilting anchor. All anchors survived after 400 cycles of cyclic loadings and failed in the load-to-failure step. There were no significant differences between the displacements and fixation stiffnesses of the anchors in either group. The ultimate failure load was significantly smaller (p&lt;0.05) for tilting anchors in ovine group (273.7 ± 129.72 N vs. 375.6 ± 106.36 N), but not different in human group (311.8 ± 82.55 N vs. 281.9 ± 88.35). Also, a larger number of tilting anchors were pulled out in ovine group (6 vs. 3) but a smaller number in human group (4 vs. 6).ConclusionIt was concluded that the biomechanical performance of the designed tilting anchor is comparable with that of the standard screw-type anchors.
Quantitative analysis of endobronchial elastography combined with serum tumour markers of lung cancer in the diagnosis of benign and malignant mediastinal and hilar lymph nodes
Authors: Wang Zhen , Li Peng , Bai Jiayu , Liu Yujia , Jiao Guangyu 
Published: November 2023

Purpose: In malignant tumours, elastography and serum tumour markers have shown high diagnostic efficacy. Therefore, we aimed to quantitatively analyse the results of endobronchial elastography combined with serum tumour markers of lung cancer to accurately distinguish benign and malignant mediastinal and hilar lymph nodes.Methods: Data of patients who underwent endobronchial ultrasound-guided transbronchial needle aspiration for mediastinal lymph node enlargement in our hospital between January 2018 and August 2022 were retrospectively collected. The characteristics of quantitative elastography and serum tumour markers were evaluated.Results: We enrolled 197 patients (273 lymph nodes). In the differential diagnosis of benign and malignant mediastinal and hilar lymph nodes, the stiffness area ratio (SAR), strain ratio (SR), and strain rate in lymph nodes were significant, among which SAR had the highest diagnostic value (cut-off value, 0.409). The combination of the four tumour markers had a high diagnostic value (AUC, 0.886). Three types of quantitative elastography indices combined with serum tumour markers for lung cancer showed a higher diagnostic value (AUC, 0.930; sensitivity, 83.5%; specificity, 89.3%; positive predictive value, 88.1%; negative predictive value, 85%) (p &lt; 0.05). In the differential diagnosis of pathological types of lung cancer, different quantitative elastography indicators and serum tumour markers for lung cancer have different diagnostic significance for the differential diagnosis of lung cancer pathological types.Conclusion: The quantitative analysis of endobronchial ultrasound elastography combined with tumour markers can improve the diagnosis rate of benign and malignant mediastinal and hilar lymph nodes, help guide the puncture of false negative lymph nodes, and reduce the misdiagnosis rate.
Ruang Virtual : Wujud Kreativitas Digital di Ruang Publik
Authors: Isfiaty Tiara , Saleh Adzkay Dani 
Published: November 2023

Ruang virtual merupakan trend kreativitas ruang yang memanfaatkan media audio visual berbasis teknologi digital. Dalam ruang virtual, teknologi digital dimanfaatkan agar pengguna ruang berkesempatan melakukan suatu aktivitas tertentu dengan tujuan mendapatkan pengalaman ruang yang berbeda dengan ruang konvensional. Pengalaman tersebut menghadirkan pengalaman ruang yang berbeda dengan ruang konvensional. Adapun keutamaan penelitian ini adalah sebagai alternatif perancangan ruang virtual berdasarkan karakteristik inovasi yang dapat mempengaruhi keputusan seorang individu untuk mengadopsi atau menolak suatu inovasi. Untuk itu penelitian ini bertujuan (a) mengidentifikasi karakteristik aktivitas pengguna ruang saat berpartisipasi dengan media audio visual berbasis teknologi digital (b) mengeksplorasi persepsi yang terbentuk dari pengguna ruang publik. Penelitian menggunakan metode penelitian kualitatif sesuai dengan tujuan penelitian yang menitikberatkan pada pemahaman akan suatu pengalaman ruang digital. Hasil dari penelitian mendapatkan bahwa (a) media audio visual berbasis teknologi digital berpengaruh terhadap pola aktivitas, berupa cara duduk, frekuensi serta durasi pengguna selama berada dalam ruang digital (b) partisipan dan atraktif menjadi pola interaksi media digital dengan pengguna ruang yang merubah persepsi mereka tentang fungsi ruang publik
Pengaruh Faktor–Faktor Produksi Terhadap Produksi Padi Sawah (Studi Kasus : Desa Pasar Miring Kecamatan Pagar Merbau Kabupaten Deli Serdang)
Authors: Baldan Panjaitan Faisal Azhari , Balatif Fuad , Sumiati Sumiati 
Published: November 2023

Faktor yang menyebabkan penurunan produksi adalah karena belum optimalnya penggunaan faktor-faktor produksi seperti luas lahan, bibit, pupuk, tenaga kerja dan pestisida. tujuan penelitian yang akan diteliti adalah sebagai berikut : (1)untuk menganalisis pengaruh faktor produksi luas lahan terhadap produksi padi di daerah penelitian. (2) untuk menganalisis pengaruh faktor produksi benih terhadap produksi padi di daerah penelitian. (3) untuk menganalisis pengaruh faktor produksi pupuk terhadap produksi padi di daerah penelitian. Model analisis yang digunakan dalam penelitian ini adalah model regresi berganda. Secara parsial variabel luas lahan (X1), berpengaruh signifikan terhadap produksi padi sawah di daerah penelitian, sedangkan variabel benih (X2) berpengaruh tidak signifikan terhadap produksi padi sawah di daerah peneltian.Variabel pupuk (X3) berpengaruh signifikan terhadap produksi padi sawah di daerah penelitian. Secara simultan pengaruh variabel bebas luas lahan (X1), Benih (X2) dan Pupuk (X3) terhadap produksi padi sawah didaerah penelitian menunjukkan berpengaruh signifikan terhadap variabel produksi (Y).
FACTORS INFLUENCING UNDERGRADUATE STUDENTS' INTENTION TO USE ONLINE EDUCATION PLATFORMS
Authors: Feng Lijuan , Li Changhan 
Published: November 2023

The aim of this study is to examine the factors influencing intention to use e-learning platforms in universities in Sichuan, China. Research design, data and methodology: Quantitative methods and data collection A questionnaire was used as a tool to collect sample data. Prior to distributing the questionnaires, the content validity and reliability were assessed using Item-Objective Congruence and pilot testing. Goodness of model fit was analyzed by confirmatory factor analysis and structural equation modeling, and causal relationships between variables were determined for hypothesis testing.
The study found that the conceptual model was able to predict behavioral intention (BI) to use mobile educational platforms in higher education, and that perceived ease of use (PEU) and attitude towards use (ATT) were the two key antecedents of behavioral intention to use mobile educational platforms.
It is concluded that ATT is the strongest factor in direct BI use and that social influence, convenience and expected performance have a significant effect on ATT. Therefore, this study suggests that mobile educational platform developers and higher education administrators should focus on improving the usability factors of mobile educational platforms so that students find the platform useful and further develop good attitudes and behavioral intentions to use mobile educational platforms.
THE DEVELOPMENT OF A MODEL TO ENHANCE STUDENT TRANSFORMATIONAL LEADERSHIP SKILLS FOR APPLICATION-ORIENTED UNIVERSITIES IN SHANXI PROVINCE, CHINA
Authors: Li Mengyan , Merritt Matthew Reed 
Published: November 2023

In this research, the primary purpose was to create a model for developing transformational leadership skills for application-oriented university students in Shanxi, China. The aim was to help college students smoothly enter society and have better career prospects. This study utilized qualitative and quantitative methods, conducting content analysis on ideal AOUs student transformational leadership skills, which include a sense of responsibility, self-dedication, vision, teamwork, innovation, problem-solving skills, communication, and listening. The results of the content analysis were validated by five experts. The study also collected 1,002 survey questionnaires from AOUs students in Shanxi, China.
The study found that five leadership activities influenced the level of transformational leadership skills: participation in leadership workshops, students’ councils, student clubs, volunteer activities, and social practice activities. Additionally, the study highlighted the similarities between Chinese Confucian thought and Western transformational leadership theory. The four philosophical ideas of Confucianism were found to be applicable in understanding Western leadership theories and guiding students' participation in related activities. The recommendations emphasize the prioritization of transformational leadership skills by stakeholders, recognizing their broad utility and crucial role in students' future success.
TUBERCULOCIDAL AND TUBERCULOSTАTIC ACTIVITY OF 1,2,4-TRIAZOLE DERIVATIVES IN VITRO (DETERMINATION OF MIC (MINIMUM INHIBITORY CONCENTRATION)
Authors: Davydenko P. , Borovik I. , Kulishenko O. , Zazharskyi V. , Radzykhovskyі M. , Dyshkant O. , Parchenko V. 
Published: November 2023

In recent years, the epizootic and epidemic situation of tuberculosis in animals and humans has worsened sharply in Ukraine. This is facilitated by the constant change in the morphology and biological properties of the causative agent of tuberculosis, the low efficiency of existing laboratory diagnostic methods (outdated bacteriology standards that do not meet European requirements), the emergence of multi-resistant strains of mycobacteria that are difficult to treat. Therefore, in recent decades, scientists of the world have been actively working on the creation of new chemotherapeutic agents with potential tuberculocidal and tuberculostatic activity.
In recent decades, cases of isolation of multi-resistant strains of mycobacteria have been increasingly recorded, causing infection that is difficult to treat, which poses a significant threat to the health of animals and people. The World Health Organization constantly monitors the situation of epidemic and socially significant diseases in the world. Particular attention is paid to tuberculosis. In the last decade, the WHO has developed and successfully applied the so-called DOTS strategy in the world. The essence of DOTS (Directly Observed Treatment Short-course) is strictly controlled treatment with a short course of chemotherapy. Therefore, the search for new chemotherapeutic drugs for the treatment of tuberculosis infection is a priority area of pharmaceutical chemistry.
One of the promising similar drugs are triazole derivatives, the active development of which continues at the department of natural sciences for foreign students and toxicological chemistry of the Zaporizhzhia State Medical University. Therefore, the direction of influence of these derivatives on epizootic strains of mycobacteria, the causative agents of animal tuberculosis, is promising.
STUDY OF THE EFFICIENCY OF USING THE EXPERIMENTAL BIOCIDE SANDEZ FOR THE SANITATION OF THE POULTRY WATER SUPPLY SYSTEM
Authors: Kasianenko O. , Nesterenko O. 
Published: November 2023

Ensuring the maximum level of biosecurity in farms that grow poultry without the use of antibiotics is a prerequisite for epizootic well-being. The article presents data on the development of an ecologically safe method of sanitation treatment of the water supply system of poultry houses. For sanitation treatment of the water supply system, the alkaline detergent and disinfectant "Sandez" was used, which is an aqueous solution of alkali, does not contain anti-corrosion substances and compounds that create a potential threat of negative impact on the environment. The active substance of the drug "Sandez" - sodium hydroxide causes denaturation of protoplasmic proteins of microbial cells. In the experiment, the water supply system of the poultry house was filled with a 1.5% solution of "Sandez" disinfectant and left filled with this solution for after standing for 1 hour, the aqueous solution was drained and the pipelines were washed with clean tap water. In the control, sodium hypochlorite with a concentration of 75–100 mg/dm3 of active chlorine was used to disinfect the water supply network. Environmentally safe disinfectant "Sandez" ensures compliance of water quality and safety indicators with the requirements of state sanitary standards and regulations. "Sandez" product has an excellent washing effect with water hardness up to 8 mg-eq/l, has a low corrosive effect on metal structures of technological equipment. The method of sanitation treatment of the water supply network of poultry houses in the system of veterinary and sanitary measures during poultry farming is based on the use of a 1.5% solution of the ecologically safe alkaline detergent and disinfectant "Sandez" has high disinfectant properties, provides a bactericidal effect on pathogenic microorganisms E. coli, S. enteritidis, Enterococcus spp., P. aeruginosa, microbial contamination is 24% less than a similar pokahnik in the control control.The use of this method in the system of veterinary and sanitary measures during poultry farming provides a high sanitizing effect, control of microbiological indicators of the safety of drinking water, a long-lasting antiseptic effect, prevents the emergence of resistance of microorganisms to the action of disinfectants and does not create a negative impact on the environment.