bluuebunny/crossref_metadata_2025_split huggingface dataset:
How Global Collaboration Can Improve the Medical Countermeasure Life Cycle for Infectious Disease Outbreaks
Authors: Swenson Jessica , Disbrow Gary , Johnson Robert A 
Published: January 2024

Abstract
Infectious disease outbreaks have become increasingly common and require global partnership for adequate preparedness and response. During outbreaks, medical countermeasures (MCMs)—vaccines, therapeutics, and diagnostics—need to reach patients quickly. Recent outbreaks exemplify that products with regulatory approval can expand access and reach patients quicker than investigational products. Unfortunately, insufficient funding globally and differences in funders' prioritization puts gains and future efforts at risk. Of primary concern is (1) lack of a feasible regulatory path and clinical capability to achieve regulatory approval for new MCMs for many diseases; and (2) the need for partners with the mandate, funding, and capabilities to support long-term sustainment of manufacturing capability and stockpiling of licensed products. Without collaboration, the global community runs the risk of losing the capabilities built through years of investment and being underprepared to combat future threats. Synergies between funders are critical to create long-term sustainment of products to ensure access.
Proscribing Time?: Proscription and Temporality in Terrorism Trials
Authors: Chukwuma Kodili Henry 
Published: January 2024

Abstract
This article explores the closely knit yet complex link between proscription and temporality through the examination of terrorism trials in Nigeria. Through the notion of proscribing time, this article demonstrates the ways in which proscription is enacted, imagined, and contested in light of important temporal effects. With a few exceptions, recent debates around proscription remain almost overwhelmingly focused on the banning of particular groups linked to terrorism, and on proscription power and its wider political and ethical ramifications. This “actor-oriented” focus (proscribed/proscriber), I argue, reinforces certain theoretical and ontological claims recognizable in the dominant analysis of terrorism. Moreover, such a perspective is predominantly organized around a forward-oriented logic of security preemption, which does not fully reveal the complexity and broader consequences of proscription. Thus, drawing upon relevant insights about temporality, especially as discussed in critical security studies, critical legal studies, and beyond, this article demonstrates how time is proscribed (rather than terrorist groups) to render visible the complexity and ramifications of proscription. The article, as such, contributes theoretically to ongoing debates about proscription and temporality in critical security studies more broadly. It also, empirically, makes a worthwhile contribution to a relatively small, though important, scholarship on terrorism trials in Nigeria.
The Election Effect: Democratic Leaders in Inter-Group Conflict
Authors: Chaudoin Stephen , Hummel Sarah , Park Yon Soo 
Published: January 2024

Abstract
How does the experience of being elected alter subsequent leader behavior at the international level? We argue for the existence of an election effect, through which a democratic election intensifies in-group identification and generates a sense of obligation to voters, while simultaneously increasing out-group hostility. These combined effects cause leaders to overexert costly efforts in competitive situations against other groups. Using an online laboratory experiment, we show that democratic leader selection increases effort in inter-group contest games, which share key features with interstate conflicts. We use a carefully specified decomposition strategy to distinguish the election effect from better-known selection effects, wherein eventual leaders are nonrandomly chosen. Our results show that a democratic election has negative implications in inter-group games, despite the near-universally positive effects of democracy found in intra-group ones.
Cross-Network Weaponization in the Semiconductor Supply Chain
Authors: Beaumier Guillaume , Cartwright Madison 
Published: January 2024

Abstract
How do states’ positions across multiple and interconnected economic networks affect their power? The Weaponized Interdependence (WI) scholarship emphasizes that states centrally located in global economic networks have access to new sources of coercion. In this paper, we look at how their positions across multiple networks interact with each other to create new opportunities and vulnerabilities. We use network analysis to map the semiconductor supply chain and show that it can be viewed as four interrelated networks: (1) design, (2) raw material, (3) manufacturing equipment, and (4) assembled chips. We then highlight how states’ centrality varies across these networks and how it shapes their respective opportunities for coercion. Looking specifically at the United States, we emphasize how its centrality in the design network enables it to weaponize chokepoints in the trade network of assembled chips. In so doing the paper makes three contributions. First, it highlights how interactions among multiple economic networks provide new opportunities for states to weaponize interdependence. Second, it contributes to recent attempts using network analysis to analyze structural power on the global stage. Last, it demonstrates how network methodology can help detect potential (ab)uses of WI and how the potential for weaponization evolves over time.
Non-steroidal anti-inflammatory drug induced intestinal stricturing: diaphragm disease
Authors: Johnson Nathan , Solkar Maseera , Sehgal Rishabh , Riyad Kallingal 
Published: January 2024

Abstract
Diaphragm disease (DD) is a rare small bowel enteropathy associated with non-steroidal anti-inflammatory drug use. Since the first description there have only been approximately 100 cases of DD reported in the literature. Stricturing webs or ‘diaphragms’ form in the bowel, causing non-specific abdominal symptoms that can ultimately lead to bleeding and obstruction. Diagnosis is notoriously challenging as there is no single gold standard investigation. We present two cases of DD both of which were ultimately diagnosed by surgical resection. We also propose a novel flow algorithm that can be utilized for working up patients with suspected DD.
Dysphagia lusoria in a young patient with a concomitant aortic arch anomaly, successfully treated with surgery: a case report
Authors: Endara Santiago A , Dávalos Gerardo A , Cardenas Alberto , Gangotena Karina , Flores Alexis , Dueñas Sabine , Molina Gabriel A 
Published: January 2024

Abstract
Dysphagia is a common condition in clinical practice; however, an unusual type of dysphagia due to compression of the esophagus by an abnormal right subclavian artery may be discovered in a rare subset of patients. The prognosis and treatment will depend on the severity of the symptoms and the compromise of surrounding structures. We present the case of an 18-year-old female who presented with gradually progressive dysphagia. At first, it was treated as gastroesophageal reflux disease; nonetheless, the dysphagia became severe, and after a thorough evaluation, an aberrant right subclavian artery that compressed the esophagus was discovered along with a truncus bicaroticus. She was successfully treated with surgery without any complications. On follow-ups, she’s doing well.
Management of ‘floating arm’: a case report of adolescent ipsilateral proximal humerus fracture with open distal complex intraarticular fracture
Authors: Alqahtani Yousef S , Alotaibi Bader N , Alqahtani Lujane S , Aljaafri Ziad A 
Published: January 2024

Abstract
Simultaneous ipsilateral fractures of the proximal and distal humerus, known as ‘floating arm’, are rarely seen in adolescents and are considered challenging to manage. Most of the published cases have involved proximal humerus and distal supracondylar fractures. This paper presents a special case of floating arm injury in a 14-year-old boy following a motor vehicle accident that was managed in a well-established trauma center. The injury consisted of displaced proximal humerus and open distal T-condylar intraarticular fractures. The patient was discharged in good condition and regained functionality with no reported complications.
Sacrococcygeal teratoma in an adult female patient—case report and review of literature
Authors: Alsahouri Mohammad I , Alsalah Qusai A , Abufara Arein A , Hammouri Ahmad G , Alzatari Ibrahim , Qumsieh Usama 
Published: January 2024

Abstract
Sacrococcygeal teratoma (SCT) in adults is very rare with only a few cases documented in the literature, adult prevalence varies between 1 in 40 000 and 1 in 63 000. Most SCTs are located either mainly extra-pelvic (types I and II), which are more commonly seen in neonates; however, mainly intra-pelvic tumors (types III and IV) are more typical in adulthood. Extra-pelvic teratomas are extremely rare in adults. When SCT manifests in an adult, it appears as a slow-growing tumor without symptoms and usually manifests after becoming large enough to cause compression symptoms. SCT has a 1–2% probability of malignant transformation. Herein, we report a 20-year-old female, who was diagnosed with lower back swelling since childhood that increased in size over the last 2 months; imaging revealed an extra-pelvic mass. This case describes an atypical scenario for SCT, which was successfully managed with surgery. The histopathology report confirmed the diagnosis.
Emphysematous changes in pneumoperitoneum and tension pneumothorax following robot-assisted bronchoscopy: a case report
Authors: Vuong Richard Q , Liechty Shawn T , Nicoara Michael D 
Published: January 2024

Abstract
Pneumoperitoneum is most commonly caused by perforation of a hollow viscus but can also result as an extension of pneumothorax and/or pneumomediastinum. We present a case of pneumoperitoneum preceded by intraprocedural hemoptysis and tension pneumothorax that developed during transbronchial needle aspiration using robot-assisted flexible bronchoscopy. After stabilization and management of the pneumothorax, diagnostic laparoscopy was performed and revealed no evidence of diaphragmatic or intra-abdominal perforation but showed diffuse emphysematous changes in the gastrohepatic ligament, small and large bowel mesentery, and preperitoneal space. These findings suggest the implication of subserosal and preperitoneal emphysema as the pathophysiological mechanism of pneumoperitoneum and pneumothorax complicating bronchoscopy procedures.
The epidemiology of imported and locally acquired dengue in Australia, 2012–2022
Authors: Sohail Asma , Anders Katherine L , McGuinness Sarah L , Leder Karin 
Published: January 2024

Abstract

Background
Dengue is the most important arboviral disease globally and poses ongoing challenges for control including in non-endemic countries with competent mosquito vectors at risk of local transmission through imported cases. We examined recent epidemiological trends in imported and locally acquired dengue in Australia, where the Wolbachia mosquito population replacement method was implemented throughout dengue-prone areas of northern Queensland between 2011 and 2019.

Methods
We analysed dengue cases reported to the Australian National Notifiable Disease Surveillance System between January 2012 and December 2022, and Australian traveller movement data.

Results
Between 2012 and 2022, 13 343 dengue cases were reported in Australia (median 1466 annual cases); 12 568 cases (94.2%) were imported, 584 (4.4%) were locally acquired and 191 (1.4%) had no origin recorded. Locally acquired cases decreased from a peak in 2013 (n = 236) to zero in 2021–22. Annual incidence of imported dengue ranged from 8.29/100 000 (n = 917 cases) to 22.10/100 000 (n = 2203) annual traveller movements between 2012 and 2019, decreased in 2020 (6.74/100 000 traveller movements; n = 191) and 2021 (3.32/100 000 traveller movements; n = 10) during COVID-19-related border closures, then rose to 34.79/100 000 traveller movements (n = 504) in 2022. Imported cases were primarily acquired in Southeast Asia (n = 9323; 74%), Southern and Central Asia (n = 1555; 12%) and Oceania (n = 1341; 11%). Indonesia (n = 5778; 46%) and Thailand (n = 1483; 12%) were top acquisition countries. DENV-2 (n = 2147; 42%) and DENV-1 (n = 1526; 30%) were predominant serotypes.

Conclusion
Our analysis highlights Australia’s successful control of locally acquired dengue with Wolbachia. Imported dengue trends reflect both Australian travel destinations and patterns and local epidemiology in endemic countries.
Tulip transcription factor TgWRKY75 activates salicylic acid and abscisic acid biosynthesis to synergistically promote petal senescence
Authors: Meng Lin , Yang Haipo , Yang Jinli , Wang Yaping , Ye Tiantian , Xiang Lin , Chan Zhulong , Wang Yanping 
Published: January 2024

Abstract
WRKY transcription factors play a central role in controlling plant organ senescence; however, it is unclear whether and how they regulate petal senescence in the widely grown ornamental plant tulip (Tulipa gesneriana). In this study, we report that TgWRKY75 promotes petal senescence by enhancing the synthesis of both abscisic acid (ABA) and salicylic acid (SA) in tulip and in transgenic Arabidopsis. The expression level of TgWRKY75 was up-regulated in senescent petals, and exogenous ABA or SA treatment induced its expression. The endogenous contents of ABA and SA significantly increased during petal senescence and in response to TgWRKY75 overexpression. Two SA synthesis-related genes, TgICS1 and TgPAL1, were identified as direct targets of TgWRKY75, which binds to their promoters. In parallel, TgWRKY75 activated the expression of the ABA biosynthesis-related gene TgNCED3 via directly binding to its promoter region. Site mutation of the W-box core motif located in the promoters of TgICS1, TgPAL1, and TgNCED3 eliminated their interactions with TgWRKY75. In summary, our study demonstrates a dual regulation of ABA and SA biosynthesis by TgWRKY75, revealing a synergistic process of tulip petal senescence through feedback regulation between TgWRKY75 and the accumulation of ABA and SA.
The synergistic effect of multiple organic macromolecules on the formation of calcium oxalate raphides of Musa spp.
Authors: Zhang Wenjun , Fan Yuke , Chi Jialin 
Published: January 2024

Abstract
Needle-like calcium oxalate crystals called raphides are unique structures in the plant kingdom. Multiple biomacromolecules work together in the regulatory and transportation pathways to form raphides; however, the mechanism by which this occurs remains unknown. Using banana (Musa spp.), this study combined in vivo methods including confocal microscopy, transmission electron microscopy, and Q Exactive mass spectrometry to identify the main biomolecules, such as vesicles, together with the compositions of lipids and proteins in the crystal chamber, which is the membrane compartment that surrounds each raphide during its formation. Simulations of the vesicle transportation process and the synthesis of elongated calcium oxalate crystals in vitro were then conducted, and the results suggested that the vesicles carrying amorphous calcium oxalate and proteins embedded in raphides are transported along actin filaments. These vesicles subsequently fuse with the crystal chamber, utilizing the proteins embedded in the raphides as a template for the final formation of the structure. Our findings contribute to the fundamental understanding of the regulation of the diverse biomacromolecules that are crucial for raphide formation. Moreover, the implications of these findings extend to other fields such as materials science, and particularly the synthesis of functionalized materials.
A Bifidobacterium animalis subsp. lactis strain that can suppress Helicobacter pylori: isolation, in vitro and in vivo validation
Authors: Zheng Yanyi , Zhang Silu , Zhang Tengxun , Teng Xin , Ling Xueping , Li Bin , Xiao Guoxun , Huang Song 
Published: January 2024

Abstract
The administration of probiotics is an effective approach for treatment of Helicobacter pylori, which is associated with human gastrointestinal diseases and cancers. To explore more effective probiotics for H. pylori infection elimination, bacteria from infant feces were screened in this study. We successfully isolated the Bifidobacterium animalis subsp. lactis strains and evaluated its efficacy to inhibit H. pylori growth in vitro and in vivo. The results showed that a B. animalis strain (named BB18) sustained a high survival rate after incubation in gastric juice. The rapid urease test suggested that B. animalis BB18 reduced pathogen loads in H. pylori-infected Mongolian gerbils. Alleviation of H. pylori infection-induced gastric mucosa damage and decreased levels inflammatory cytokines were observed after the B. animalis BB18 administration. These findings demonstrated that B. animalis BB18 can inhibit H. pylori infection both in vitro and in vivo, suggesting its potential application for the prevention and eradication therapy of H. pylori infection.
Long-chain acyl-CoA synthetase regulates systemic lipid homeostasis via glycosylation-dependent lipoprotein production
Authors: Li Jie , Dong Yue , Zhou Tianxing , Tian He , Huang Xiahe , Zhang Yong Q , Wang Yingchun , Lam Sin Man , Shui Guanghou 
Published: January 2024

AbstractInterorgan lipid transport is crucial for organism development and the maintenance of physiological function. Here, we demonstrate that Drosophila long-chain acyl-CoA synthetase (dAcsl), which catalyzes the conversion of fatty acids into acyl-coenzyme As (acyl-CoAs), plays a critical role in regulating systemic lipid homeostasis. dAcsl deficiency in the fat body led to the ectopic accumulation of neutral lipids in the gut, along with significantly reduced lipoprotein contents in both the fat body and hemolymph. The aberrant phenotypes were rescued by fat body-specific overexpression of apolipophorin. A multi-omics investigation comprising lipidomics, metabolomics, and proteomics in conjunction with genetic screening revealed that glycosylation processes were suppressed in dAcsl knockdown flies. Overexpression of CG9035, human ortholog of which is implicated in the congenital disorder of glycosylation, ameliorated gut lipid accumulation in Drosophila. Aberrant lipoprotein glycosylation led to accelerated proteasome-related degradation and induced ER stress in dAcsl knockdown flies, impairing lipoprotein release into the circulation which compromised interorgan lipid transport between the fat body and the gut. Inhibition of ubiquitin-proteasome-dependent degradation alleviated the phenotype of gut ectopic fat accumulation in dAcsl knockdown flies. Finally, we verified that ACSL4, the human homolog of dAcsl, also regulated lipoprotein levels in HepG2 cells, indicating that the role of dAcsl in modulating lipoprotein secretion and systemic lipid homeostasis is possibly conserved in humans.
Dynamics of the Oral Microbiome During Initial Military Training at Fort Benning, Georgia
Authors: Zudock Kristina K , Player Robert , Ernlund Amanda , Timm Collin M , English Caroline E , Ellis Michael W , Tribble David R , Merrell D Scott , Bennett Jason W , Millar Eugene V 
Published: January 2024

ABSTRACT

Introduction
Military trainees are at increased risk for infectious disease outbreaks because of the unique circumstances of the training environment (e.g., close proximity areas and physiologic/psychologic stress). Standard medical countermeasures in military training settings include routine immunization (e.g., influenza and adenovirus) as well as chemoprophylaxis [e.g., benzathine penicillin G (Bicillin) for the prevention of group A streptococcal disease] for pathogens associated with outbreaks in these settings. In a population of U.S. Army Infantry trainees, we evaluated changes in the oral microbiome during a 14-week military training cycle.

Materials and Methods
Trainees were enrolled in an observational cohort study in 2015–2016. In 2015, Bicillin was administered to trainees to ameliorate the risk of group A Streptococcus outbreaks, whereas in 2016, trainees did not receive a Bicillin inoculation. Oropharyngeal swabs were collected from participants at days 0, 7, 14, 28, 56, and 90 of training. Swabs were collected, flash frozen, and stored. DNA was extracted from swabs, and amplicon sequencing of the 16s rRNA gene was performed. Microbiome dynamics were evaluated using the QIIME 2 workflow along with DADA2, SINA with SILVA, and an additional processing in R.

Results
We observed that microbiome samples from the baseline (day 0) visit were distinct from one another, whereas samples collected on day 14 exhibited significant microbiome convergence. Day 14 convergence was coincident with an increase in DNA sequences associated with Streptococcus, though there was not a significant difference between Streptococcus abundance over time between 2015 and 2016 (P = .07), suggesting that Bicillin prophylaxis did not significantly impact overall Streptococcus abundance.

Conclusions
The temporary convergence of microbiomes is coincident with a rise in communicable infections in this population. The dynamic response of microbiomes during initial military training supports similar observations in the literature of transient convergence of the human microbiome under cohabitation in the time frame including in this experiment. This population and the associated longitudinal studies allow for controlled studies of human microbiome under diverse conditions.
LSBGnet: an improved detection model for low-surface brightness galaxies
Authors: Su Hao , Yi Zhenping , Liang Zengxu , Du Wei , Liu Meng , Kong Xiaoming , Bu Yude , Wu Hong 
Published: January 2024

ABSTRACT
The Chinese Space Station Telescope (CSST) is scheduled to launch soon, which is expected to provide a vast amount of image potentially containing low-surface brightness galaxies (LSBGs). However, detecting and characterizing LSBGs is known to be challenging due to their faint surface brightness, posing a significant hurdle for traditional detection methods. In this paper, we propose LSBGnet, a deep neural network specifically designed for automatic detection of LSBGs. We established LSBGnet-SDSS model using data set from the Sloan Digital Sky Survey (SDSS). The results demonstrate a significant improvement compared to our previous work, achieving a recall of 97.22 per cent and a precision of 97.27 per cent on the SDSS test set. Furthermore, we use the LSBGnet-SDSS model as a pre-training model, employing transfer learning to retrain the model with LSBGs from Dark Energy Survey (DES), and establish the LSBGnet-DES model. Remarkably, after retraining the model on a small DES sample, it achieves over 90 per cent precision and recall. To validate the model’s capabilities, we utilize the trained LSBGnet-DES model to detect LSBG candidates within a selected 5 sq. deg area in the DES footprint. Our analysis reveals the detection of 204 LSBG candidates, characterized by a mean surface brightness range of $23.5\ \mathrm{ mag}\ \mathrm{ arcsec}^{-2}\le \bar{\mu }_{\text{eff}}(g)\le 26.8\ \mathrm{ mag}\ \mathrm{ arcsec}^{-2}$ and a half-light radius range of 1.4 arcsec ≤ r1/2 ≤ 8.3 arcsec. Notably, 116 LSBG candidates exhibit a half-light radius ≥2.5 arcsec. These results affirm the remarkable performance of our model in detecting LSBGs, making it a promising tool for the upcoming CSST.