bluuebunny/crossref_metadata_2025_split huggingface dataset:
Cohort profile update–overview of over 35 years of research in the Dortmund Nutritional and Anthropometric Longitudinally Designed (DONALD) study
Authors: Perrar Ines , Alexy Ute , Nöthlings Ute 
Published: December 2023

Abstract
Purpose
To provide an update on the cohort profile of the DOrtmund Nutritional and Anthropometric Longitudinally Designed (DONALD) study, including objectives, study design, methods and description of the comprehensive data pool, as well as to summarize the most important research findings of recent years.

Methods
In 1985, the open (dynamic) cohort started to collect information on diet, growth, development, and metabolism of healthy children and adolescents in Dortmund, Germany. Detailed data are collected annually during infancy, childhood, and adolescence of the participants, including a 3-day weighed dietary record, a 24-h urine sample, anthropometric and medical examinations as well as interviews on lifestyle.

Results
Even if the basic examination modules have not changed since the start over 35 years ago, the DONALD study has been continuously further developed by introducing new modules. As such, participants are also invited for follow-up examinations during adulthood since 2005, including an additional fasting blood withdrawal. Overall, 2375 (♂: 1177; ♀: 1198) participants were recruited in the DONALD study between 1985 and 2022. Data from ~ 30,700 anthropometric measurements, ~ 19,200 dietary records, ~ 10,600 24-h urine and ~ 1300 blood samples are available from an observation period of over 35 years.

Conclusion
The DONALD study provides a large data pool for longitudinal studies on nutrition, growth, and health in childhood and adolescence, its impact on the development of diseases in early adult life as well as dietary intake trends over more than three decades.
From the detection of monitoring anomalies to the probabilistic forecast of the evolution of volcanic unrest: an entropy-based approach
Authors: Marzocchi Warner , Sandri Laura , Ferrara Salvatore , Selva Jacopo 
Published: December 2023

AbstractOwing to the current lack of plausible and exhaustive physical pre-eruptive models, often volcanologists rely on the observation of monitoring anomalies to track the evolution of volcanic unrest episodes. Taking advantage from the work made in the development of Bayesian Event Trees (BET), here we formalize an entropy-based model to translate the observation of anomalies into probability of a specific volcanic event of interest. The model is quite general and it could be used as a stand-alone eruption forecasting tool or to set up conditional probabilities for methodologies like the BET and of the Bayesian Belief Network (BBN). The proposed model has some important features worth noting: (i) it is rooted in a coherent logic, which gives a physical sense to the heuristic information of volcanologists in terms of entropy; (ii) it is fully transparent and can be established in advance of a crisis, making the results reproducible and revisable, providing a transparent audit trail that reduces the overall degree of subjectivity in communication with civil authorities; (iii) it can be embedded in a unified probabilistic framework, which provides an univocal taxonomy of different kinds of uncertainty affecting the forecast and handles these uncertainties in a formal way. Finally, for the sake of example, we apply the procedure to track the evolution of the 1982–1984 phase of unrest at Campi Flegrei.
Pribadi: A decentralized privacy-preserving authentication in wireless multimedia sensor networks for smart cities
Authors: Goyat Rekha , Kumar Gulshan , Saha Rahul , Conti Mauro 
Published: December 2023

AbstractWireless Multimedia Sensor Network (WMSN) is a network of interconnected sensor nodes equipped with multimedia devices capable to retrieve multimedia as well as scalar sensor data in smart city scenarios. With the progress of smart city development, WMSNs are becoming points of interest. The existing research works on the security of WMSNs show some significant centralized solutions; they are prone to denial of service attacks, central failure, and privacy breaches. Also, these solution are having limitations because of their centralized nature.Therefore, the the proposed scheme adopted the concept of decentralization to achieve more effective and ubiquitous results. As per our best knowledge, we introduce the first decentralized privacy-preserving authentication framework for WMSNs to address the energy and storage challenges. We call our solution PRIvacy-preserving Blockchain-based Authentication for multimeDIa networks (PRIBADI). PRIBADI uses a blockchain framework for authenticated communication between sensor nodes and base stations (as a trusted authority) by using certification and access authentication schemes. We elect trustworthy cluster heads based on weight metrics and these cluster heads forward the information to the Trusted Authority (TA). Subsequently, TA forward large data to the cloud for storage, and the information relevant to certificates and hashes are recorded on the distributed blockchain. Moreover, TA revokes the certificates of malicious sensor nodes and eliminates them from the blockchain. We run a set of experiments on PRIBADI and compare the results with the state-of-the-art models. We use the evaluation criteria of detection accuracy, operation, and energy consumption. We find that PRIBADI is 31.7% better than the existing models.
Echinacea purpurea extract intervention for counteracting neurochemical and behavioral changes induced by bifenthrin
Authors: Abdel-Wahhab Khaled G. , Sayed Rehab S. , EL-Sahra Doaa G. , Hassan Laila K. , Elqattan Ghada M. , Mannaa Fathia A. 
Published: December 2023

AbstractThis study was conducted to elucidate the possible protective efficiency of Echinacea purpurea hydroethanolic extract (EchEE) against bifenthrin (BIF)-induced neuro-chemical and behavioral changes in rats. Total phenolics content, reducing power and radical scavenging activity of EchEE were estimated. Four groups of adult male albino rats were used (10 rats each) as follows: 1) Control healthy rats ingested with placebo, 2) Healthy rats orally received EchEE (465 mg/kg/day), 3) Rats intoxicated with BIF (7mg/kg/day) dissolved in olive oil, and 4) Rats co-treated with EchEE (465 mg/kg/day) besides to BIF (7mg/kg/day) intoxication. After 30 days, some neuro-chemical and behavioral tests were assessed. The behavioral tests revealed that rats received BIF exhibited exploratory behavior and spatial learning impairments, memory and locomotion dysfunction, and enhanced anxiety level. Biochemical findings revealed that BIF induced-oxidative stress in the cortex and hippocampus; this was appeared from the significant rise in malondialdehyde (MDA) and nitric oxide (NO) levels, coupled with decreased catalase (CAT), superoxide dismutase (SOD), paraoxonase-1 (PON-1) activities, and reduced glutathione (GSH) level in both brain areas. Also, BIF induced a significant increase caspas-3, tumor necrosis factor alpha (TNF), and interleukin-1beta (IL-1ß) in both areas; dopamine and serotonin levels, and ACh-ase activity were markedly decreased in both areas. Interestingly, treatment of rats with EchEE in combination with BIF resulted in a significant decrease in oxidative stress damage, and modulation of the apoptotic and pro-inflammatory markers. Also, EchEE markedly improved behavioral activities and neurotransmitters level that were impaired by BIF. In conclusion, the present study clearly indicated that EchEE can attenuate brain dysfunction induced by pesticides exposure through preventing the oxidative stress. This may be attributed to its high antioxidant component.
Exact solutions, symmetry groups and conservation laws for some (2+1)-dimensional nonlinear physical models
Authors: Hassan M. M. , Shehata A. R. , Abdel-Daym M. S. 
Published: December 2023

AbstractIn this paper, the Bernoulli sub-equation function method is used to construct new exact travelling wave solutions for two important physical models: (2+1)-dimensional hyperbolic nonlinear Schrödinger (HNLS) equation and (2+1)-dimensional Heisenberg ferromagnetic spin chain (HFSC) equation. These solutions provide valuable insights into the behavior of these models, described in terms of exponential and hyperbolic tangent (tanh) functions. The study also involves an exploration of the infinitesimal generators and symmetry groups through the Lie symmetry method. In addition, by using multiplier approach, the conservation laws are established for these models. Graphical simulation of some solutions in the form of two-dimensional and three-dimensional are plotted to understanding of the underlying physical phenomena and mathematical properties of the (2+1)-dimensional HNLS and HFSC equations. The solutions and graphing are performed using Maple software.
Deep Depth from Focal Stack with Defocus Model for Camera-Setting Invariance
Authors: Fujimura Yuki , Iiyama Masaaki , Funatomi Takuya , Mukaigawa Yasuhiro 
Published: December 2023

AbstractWe propose deep depth from focal stack (DDFS), which takes a focal stack as input of a neural network for estimating scene depth. Defocus blur is a useful cue for depth estimation. However, the size of the blur depends on not only scene depth but also camera settings such as focus distance, focal length, and f-number. Current learning-based methods without any defocus models cannot estimate a correct depth map if camera settings are different at training and test times. Our method takes a plane sweep volume as input for the constraint between scene depth, defocus images, and camera settings, and this intermediate representation enables depth estimation with different camera settings at training and test times. This camera-setting invariance can enhance the applicability of DDFS. The experimental results also indicate that our method is robust against a synthetic-to-real domain gap.
Unraveling intragenomic polymorphisms in the high-quality genome of Hypoxylaceae: a comprehensive study of the rDNA cistron
Authors: Cedeño-Sanchez Marjorie , Cheng Tian , Lambert Christopher , Kolarík Miroslav , Kuhnert Eric , Cox Russell J. , Kalinowski Jörn , Verwaaijen Bart , Stadler Marc 
Published: December 2023

AbstractSequencing ribosomal DNA loci, such as ITS and LSU, are among the first steps to characterize and identify newly isolated fungal strains. Substantial doubt has recently been raised concerning the unequivocal suitability of using this sequence information for inferring inter- and intraspecific relationships, as especially the ITS locus was repeatedly shown to harbor high intragenomic plasticity. The evolutionary mechanisms leading to this phenomenon are poorly understood, but this is about to change, owing to the availability of third generation sequencing techniques. The current study attempts a comprehensive analysis of rDNA cistrons in the genomes of over 40 selected species of Hypoxylaceae (Xylariales), using a combination of 2nd generation (Illumina) and 3rd generation sequencing technologies (Oxford Nanopore), along with extensive usage of bioinformatic tools to obtain high-quality genomes. Our findings revealed high intragenomic polymorphisms in distinct Hypoxylaceae species, indicating the presence of deep rDNA paralogs. Phylogenetic inference of the ITS rDNA showed low support for the primary clades within Hypoxylaceae, while inference using the protein encoding gene RPB2 showed better support. We also found that proteinogenic genes are not prone to intraspecific and intragenomic polymorphisms as much as the rDNA loci. Our study highlights the limitations of solely relying on the rDNA cistron as a barcode for fungi. We propose TUB2 as a new primary barcoding marker for Hypoxylaceae and other Xylariales. Moreover, we demonstrate the feasibility to retrieve some DNA loci that had hitherto not been used for classical phylogenetic studies (such as TEF1) in Xylariales directly from genomes without the necessity to work with primers.
miR-155-5p/Bmal1 Modulates the Senescence and Osteogenic Differentiation of Mouse BMSCs through the Hippo Signaling Pathway
Authors: Zhang Lanxin , Zhang Chengxiaoxue , Zheng Jiawen , Wang Yuhong , Wei Xiaoyu , Yang Yuqing , Zhao Qing 
Published: December 2023

Abstract
Background
The core clock gene brain and muscle ARNT like-1 (Bmal1) is involved in the regulation of bone tissue aging. However, current studies are mostly limited to the establishment of the association between Bmal1 and bone senescence, without in-depth exploration of its main upstream and downstream regulatory mechanisms.

Methods
The luciferase reporter assay, RT-qPCR and Western blotting were performed to detect the interaction between miR-155-5p and Bmal1. The effects of miR-155-5p and Bmal1 on the aging and osteogenic differentiation ability of mouse bone marrow mesenchymal stem cells (BMSCs) were investigated by cell counting kit-8 (CCK-8) assay, flow cytometry, β-gal staining, alkaline phosphatase quantitative assay and alizarin red staining in vitro. The potential molecular mechanism was identified by ChIP-Seq, RNA-seq database analysis and immunofluorescence staining.

Results
The expression of Bmal1 declined with age, while the miR-155-5p was increased. miR-155-5p and Bmal1 repressed each other’s expression, and miR-155-5p targeted the Bmal1. Besides, miR-155-5p inhibited the proliferation and osteogenic differentiation of BMSCs, promoted cell apoptosis and senescence, inhibited the expression and nuclear translocation of YAP and TAZ. However, Bmal1 facilitated the osteogenic differentiation and suppressed the aging of BMSCs, meanwhile inactivated the Hippo pathway. Moreover, YAP inhibitors abrogated the positive regulation of aging and osteogenic differentiation in BMSCs by miR-155-5p and Bmal1.

Conclusion
In mouse BMSCs, miR-155-5p and Bmal1 regulated the aging and osteogenic differentiation ability of BMSCs mainly through the Hippo signaling pathway. Our findings provide new insights for the interventions in bone aging.

Graphical Abstract
“Time is on me”: Entangled Temporalities Between Italy and the Gambia
Authors: Castellano Viola 
Published: December 2023

AbstractGambian’s migration towards Europe, mainly constituted by young men, substantially increased since 2010. Arriving mainly through the Central Mediterranean Route because of the extremely scarce possibility to obtain a visa, most Gambians applied for asylum in Italy, the first arrival country according to the Dublin regulation. The administrative and juridical system largely rejected their asylum requests, leaving most undocumented, in legal limbo, and deportable. The paper focuses on the different trajectories of Gambians in Italy in their post-asylum phase, discussing how existential precariousness heavily shapes their lives and how this condition compromises future building along different but entangled temporalities. In particular, the contribution wants to reflect on the various intertwined timelines that people on the move forge and inhabit, showing how they are always multiple and articulated through spatial, social, cultural, economic, and personal dimensions. In so doing, I analyze temporal dispossession as a continuous process that Gambians on the move experience prior to, during, and after their trip to Europe and which they actively struggle to overcome.
Planar Pseudo-geodesics and Totally Umbilic Submanifolds
Authors: Markvorsen Steen , Raffaelli Matteo 
Published: December 2023

AbstractWe study totally umbilic isometric immersions between Riemannian manifolds. First, we provide a novel characterization of the totally umbilic isometric immersions with parallel normalized mean curvature vector, i.e., those having nonzero mean curvature vector and such that the unit vector in the direction of the mean curvature vector is parallel in the normal bundle. Such characterization is based on a family of curves, called planar pseudo-geodesics, representing a natural extrinsic generalization of both geodesics and Riemannian circles: being planar, their Cartan development in the tangent space is planar in the ordinary sense; being pseudo-geodesics, their geodesic and normal curvatures satisfy a linear relation. We study these curves in detail and, in particular, establish their local existence and uniqueness. Moreover, in the case of codimension-one immersions, we prove the following statement: an isometric immersion $$\iota :M \hookrightarrow Q$$

ι
:
M
↪
Q

is totally umbilic if and only if the extrinsic shape of every geodesic of M is planar. This extends a well-known result about surfaces in $$\mathbb {R}^{3}$$

R

3

.
Metastasis-directed therapy: new standard or too early to change paradigm?
Authors: Klemm Jakob , Rajwa Pawel , Miszczyk Marcin , Brönimann Stephan , Laukhtina Ekaterina , Tsuboi Ichiro , Matsukawa Akihiro , Parizi Mehdi Kardoust , Karakiewicz Pierre I. , Shariat Shahrokh F. 
Published: December 2023

SummaryMetastasis-directed therapy (MDT) is an emerging treatment strategy for patients with oligometastatic prostate cancer (PCa), particularly for oligorecurrent disease. This review aims to summarize findings from several prospective trials in the setting of oligorecurrent PCa. We found that MDT is feasible, has high tolerability, and is effective in terms of local control of treated lesions and of deferring disease progression in well-selected patients. Selecting patients for MDT requires thoughtful consideration of factors such as the castration status, the number of detected metastases, and the imaging modality used for metastasis detection. Notably, the studies included in this review varied in terms of these factors, complicating the comparability of their results. Despite the existence of several prospective clinical trials in the field, there is an absence of high-level evidence attributable to the lack of phase 3 clinical trials. As a result, current guidelines recommend the administration of MDT exclusively within the context of clinical trials. Despite this, retrospective series indicate that MDT is already frequently utilized outside of clinical trials.
The influence of chronic renal insufficiency on multi-therapeutic modalities for breast cancer: a single-center experience
Authors: Hong Yi-Wen , Kuo I-Ming , Kuo Wen-Ling , Yu Chi-Chang , Shen Shih-Che , Tsai Hsiu-Pei , Chu Chia-Hui , Ho Hui-Yu , Lo Yung-Feng , Chen Shin-Cheh , Lin Yung-Chang , Chien Chih-Ying , Chou Hsu-Huan 
Published: December 2023

Abstract
Background
Due to the presence of other comorbidities and multi-therapeutic modalities in breast cancer, renally cleared chemotherapeutic regimens may cause nephrotoxicity. The aim of this retrospective study is to compare the chemotherapy types and outcomes in breast cancer patients with or without chronic renal disease.

Patients and Methods
We retrospectively enrolled 62 female patients with breast cancer and underlying late stages (stage 3b, 4, and 5) of chronic kidney disease (CKD) treated from 2000 to 2017. They were propensity score-matched 1:1 with patients in our database with breast cancer and normal renal function (total n = 124).

Results
The main subtype of breast cancer was luminal A and relatively few patients with renal impairment received chemotherapy and anti-Her-2 treatment. The breast cancer patients with late-stage CKD had a slightly higher recurrent rate, especially at the locally advanced stage. The 5-year overall survival was 90.1 and 71.2% for patients without and with late-stage CKD, but the breast cancer-related mortality rate was 88.9 and 24.1%, respectively. In multivariate analyses, dose-reduced chemotherapy was an independent negative predictor of 5-year recurrence-free survival and late-stage CKD was associated with lower 5-year overall survival rate.

Conclusions
Breast cancer patients with late-stage CKD may receive insufficient therapeutic modalities. Although the recurrence-free survival rate did not differ significantly by the status of CKD, patients with breast cancer and late-stage CKD had shorter overall survival time but a lower breast cancer-related mortality rate, indicated that the mortality was related to underlying disease.
Global existence for perturbations of the 2D stochastic Navier–Stokes equations with space-time white noise
Authors: Hairer Martin , Rosati Tommaso 
Published: December 2023

AbstractWe prove global in time well-posedness for perturbations of the 2D stochastic Navier–Stokes equations $$\begin{aligned} \partial _t u + u \cdot \nabla u= & {} \Delta u - \nabla p + \zeta + \xi \;, \qquad u (0, \cdot ) = u_{0} \;,\\ {\text {div}}(u)= & {} 0 \;, \end{aligned}$$

∂
t

u
+
u
·
∇
u
=

Δ
u
-
∇
p
+
ζ
+
ξ

,

u

(
0
,
·
)

=

u
0

,

div
(
u
)
=

0

,

driven by additive space-time white noise $$ \xi $$
ξ
, with perturbation $$ \zeta $$
ζ
in the Hölder–Besov space $$\mathcal {C}^{-2 + 3\kappa } $$

C

-
2
+
3
κ

, periodic boundary conditions and initial condition $$ u_{0} \in \mathcal {C}^{-1 + \kappa } $$

u
0

∈

C

-
1
+
κ

for any $$ \kappa >0 $$

κ
>
0

. The proof relies on an energy estimate which in turn builds on a dynamic high-low frequency decomposition and tools from paracontrolled calculus. Our argument uses that the solution to the linear equation is a $$ \log $$
log
–correlated field, yielding a double exponential growth bound on the solution. Notably, our method does not rely on any explicit knowledge of the invariant measure to the SPDE, hence the perturbation $$ \zeta $$
ζ
is not restricted to the Cameron–Martin space of the noise, and the initial condition may be anticipative. Finally, we introduce a notion of weak solution that leads to well-posedness for all initial data $$ u_{0}$$

u
0

in $$ L^{2} $$

L
2

, the critical space of initial conditions.
Acute Bouts of Aerobic Exercise Do Not Modulate Task-Evoked Midfrontal Theta Oscillations in School-Age Children
Authors: Hsieh Shu-Shih , Kao Shih-Chun , Raine Lauren B. , Lloyd Katherine M. , Pontifex Matthew B. , Hillman Charles H. 
Published: December 2023

AbstractWhile acute aerobic exercise has been found to have a facilitative effect on task components with varied cognitive control demands in school-age children, its effects on specific neural processes evoked by a cognitive control task remain underexplored. The objective of the current study was to examine the effects of acute aerobic exercise on task-evoked midfrontal theta event-related synchronization (ERS)—which plays a crucial role in supporting cognitive control. Thirty-three preadolescent children were recruited into this within-subjects, crossover study. Participants engaged in an aerobic exercise condition and a seated rest condition in a counterbalanced order. After both conditions, participants completed a flanker task, with concurrent EEG data collection. The results revealed no differences in midfrontal theta ERS following acute aerobic exercise as compared with following the control condition. However, midfrontal theta ERS was higher during congruent trials relative to incongruent trials following control condition but not following aerobic exercise. Collectively, acute bouts of aerobic exercise do not appear to modulate the control and behavioral monitoring processes indexed by midfrontal theta ERS during cognitive control in children.
Pricing and hedging of longevity basis risk through securitisation
Authors: Zeddouk Fadoua , Devolder Pierre 
Published: December 2023

AbstractPension funds and insurers face difficulties in hedging their longevity risk, which is the uncertainty of how long their clients will live. A possible solution could be using longevity-linked securities to transfer some of this risk to other parties. However, these securities may not match the actual mortality rates of the insurer’s clients, resulting in a potential loss due to basis risk. In this paper, we measure this basis risk through the pricing of a longevity derivative under Solvency II. We also compare this method with other common pricing methods in finance. We explore and evaluate different hedging strategies for insurers, using a multi-population model derived from a two-dimensional Hull and White model that captures the dynamics of mortality over time.