bluuebunny/crossref_metadata_2025_split huggingface dataset:
Discordance between GCIG CA-125 progression and RECIST progression in the CALYPSO trial of patients with platinum-sensitive recurrent ovarian cancer
Authors: Zebic Danka Sinikovic , Tjokrowidjaja Angelina , Francis Katherine Elizabeth , Friedlander Michael , Gebski Val , Lortholary Alain , Joly Florence , Hasenburg Annette , Mirza Mansoor , Denison Ursula , Cecere Sabrina Chiara , Ferrero Annamaria , Pujade-Lauraine Eric , Lee Chee Khoon 
Published: December 2023

Abstract
Background
CA-125 alone is widely used to diagnose progressive disease (PD) in platinum-sensitive recurrent ovarian cancer (PSROC) on chemotherapy. However, there are increasing concerns regarding its accuracy. We assessed concordance between progression defined by CA-125 and RECIST using data from the CALYPSO trial.

Methods
We computed concordance rates for PD by CA-125 and RECIST to determine the positive (PPV) and negative predictive values (NPV).

Results
Of 769 (79%) evaluable participants, 387 had CA-125 PD, where only 276 had concordant RECIST PD (PPV 71%, 95% CI 67–76%). For 382 without CA-125 PD, 255 had RECIST PD but 127 did not (NPV 33%, 95% CI 29–38). There were significant differences in NPV according to baseline CA-125 (≤100 vs >100: 42% vs 25%, P < 0.001); non-measurable vs measurable disease (51% vs 26%, P < 0.001); and platinum-free-interval (>12 vs 6–12 months: 41% vs 14%, P < 0.001). We observed falling CA-125 levels in 78% of patients with RECIST PD and CA-125 non-PD.

Conclusion
Approximately 2 in 3 women with PSROC have RECIST PD but not CA-125 PD by GCIG criteria. Monitoring CA-125 levels alone is not reliable for detecting PD. Further research is required to investigate the survival impact of local therapy in radiological detected early asymptomatic PD.
Hsa_circ_0013561 promotes epithelial-mesenchymal transition and tumor progression by regulating ANXA2 via miR-23b-3p in ovarian cancer
Authors: Lv Jia , Zhang Yijun , Yang Mengying , Qiao Lianqiao , Wang Huihui , Jiang Huici , Fu Mingxu , Qin Jinlong , Xu Shaohua 
Published: December 2023

AbstractOur preliminary experiment discovered that hsa_circ_0013561 was aberrantly expressed in OC. However, the underlying mechanism is unclear. The expression of hsa_circ_0013561 in OC cells and tissues was detected by RT-qPCR and fluorescence in situ hybridization. The effects of hsa_circ_0013561 on the proliferation and metastasis of OC were explored by functional experiments such as cell counting kit-8, transwell, and tumor xenograft models. To mechanistically understand the regulatory role of hsa_circ_0013561, bioinformatics analysis, Western blot, luciferase reporter assay, and a series of rescue experiments were applied. We found that the hsa_circ_0013561 expression was elevated in OC cells and tissues, and was correlated with metastasis formation. Downregulation of hsa_circ_0013561 suppressed the proliferation and migration of OC cells both in vitro and in vivo. Regarding the interactions of hsa_circ_0013561, the luciferase reporter assay verified that miR-23b-3p and Annexin A2 (ANXA2) were its downstream targets. MiR-23b-3p inhibition or ANXA2 overexpression reversed OC cell proliferation, migration, and epithelial-mesenchymal transition (EMT) post-hsa_circ_0013561 silencing. Moreover, ANXA2 overexpression also reversed OC cell migration, proliferation, and EMT after miR-23b-3p upregulation. Our data suggest that hsa_circ_0013561 increases the expression of ANXA2 by regulating miR-23b-3p competitively, resulting in EMT and metastasis of OC. Thus, hsa_circ_0013561 may serve as a novel oncogenic biomarker for OC progression.
All-optical geometric image transformations enabled by ultrathin metasurfaces
Authors: Zhang Xingwang , Zhang Xiaojie , Duan Yao , Zhang Lidan , Ni Xingjie 
Published: December 2023

AbstractImage processing plays a vital role in artificial visual systems, which have diverse applications in areas such as biomedical imaging and machine vision. In particular, optical analog image processing is of great interest because of its parallel processing capability and low power consumption. Here, we present ultra-compact metasurfaces performing all-optical geometric image transformations, which are essential for image processing to correct image distortions, create special image effects, and morph one image into another. We show that our metasurfaces can realize binary image transformations by modifying the spatial relationship between pixels and converting binary images from Cartesian to log-polar coordinates with unparalleled advantages for scale- and rotation-invariant image preprocessing. Furthermore, we extend our approach to grayscale image transformations and convert an image with Gaussian intensity profile into another image with flat-top intensity profile. Our technique will potentially unlock new opportunities for various applications such as target tracking and laser manufacturing.
The function of ER-phagy receptors is regulated through phosphorylation-dependent ubiquitination pathways
Authors: Berkane Rayene , Ho-Xuan Hung , Glogger Marius , Sanz-Martinez Pablo , Brunello Lorène , Glaesner Tristan , Kuncha Santosh Kumar , Holzhüter Katharina , Cano-Franco Sara , Buonomo Viviana , Cabrerizo-Poveda Paloma , Balakrishnan Ashwin , Tascher Georg , Husnjak Koraljka , Juretschke Thomas , Misra Mohit , González Alexis , Dötsch Volker , Grumati Paolo , Heilemann Mike , Stolz Alexandra 
Published: December 2023

AbstractSelective autophagy of the endoplasmic reticulum (ER), known as ER-phagy, is an important regulator of ER remodeling and essential to maintain cellular homeostasis during environmental changes. We recently showed that members of the FAM134 family play a critical role during stress-induced ER-phagy. However, the mechanisms on how they are activated remain largely unknown. In this study, we analyze phosphorylation of FAM134 as a trigger of FAM134-driven ER-phagy upon mTOR (mechanistic target of rapamycin) inhibition. An unbiased screen of kinase inhibitors reveals CK2 to be essential for FAM134B- and FAM134C-driven ER-phagy after mTOR inhibition. Furthermore, we provide evidence that ER-phagy receptors are regulated by ubiquitination events and that treatment with E1 inhibitor suppresses Torin1-induced ER-phagy flux. Using super-resolution microscopy, we show that CK2 activity is essential for the formation of high-density FAM134B and FAM134C clusters. In addition, dense clustering of FAM134B and FAM134C requires phosphorylation-dependent ubiquitination of FAM134B and FAM134C. Treatment with the CK2 inhibitor SGC-CK2-1 or mutation of FAM134B and FAM134C phosphosites prevents ubiquitination of FAM134 proteins, formation of high-density clusters, as well as Torin1-induced ER-phagy flux. Therefore, we propose that CK2-dependent phosphorylation of ER-phagy receptors precedes ubiquitin-dependent activation of ER-phagy flux.
Approaching national climate targets in China considering the challenge of regional inequality
Authors: Yu Biying , Zhao Zihao , Wei Yi-Ming , Liu Lan-Cui , Zhao Qingyu , Xu Shuo , Kang Jia-Ning , Liao Hua 
Published: December 2023

AbstractAchievement of national climate targets and the corresponding costs would entirely depend on regional actions within the country. However, because of substantial inequalities and heterogeneities among regions, especially in developing economies, aggressive or uniform actions may exacerbate inequity and induce huge economic losses, which in turn challenges the national climate pledges. Hence, this study extends prior research by proposing economically optimal strategies that can achieve national climate targets and ensure the greatest local and national benefits as well as regional equality. Focusing on the biggest developing country China, we find this strategy can avoid up to 1.54% of cumulative GDP losses for approaching carbon neutrality, and more than 90% of regions would obtain economic gains compared either with existing independently launched targets or with the uniform strategy that all regions achieve peak carbon emissions before 2030. We also provide optimal carbon mitigation pathways to regional peak carbon, carbon intensity and energy consumption.
Mapping protein states and interactions across the tree of life with co-fractionation mass spectrometry
Authors: Skinnider Michael A. , Akinlaja Mopelola O. , Foster Leonard J. 
Published: December 2023

AbstractWe present CFdb, a harmonized resource of interaction proteomics data from 411 co-fractionation mass spectrometry (CF-MS) datasets spanning 21,703 fractions. Meta-analysis of this resource charts protein abundance, phosphorylation, and interactions throughout the tree of life, including a reference map of the human interactome. We show how large-scale CF-MS data can enhance analyses of individual CF-MS datasets, and exemplify this strategy by mapping the honey bee interactome.
Histopathological growth patterns and tumor-infiltrating lymphocytes in breast cancer liver metastases
Authors: Leduc Sophia , De Schepper Maxim , Richard François , Maetens Marion , Pabba Anirudh , Borremans Kristien , Jaekers Joris , Latacz Emily , Zels Gitte , Bohlok Ali , Van Baelen Karen , Nguyen Ha Linh , Geukens Tatjana , Dirix Luc , Larsimont Denis , Vankerckhove Sophie , Santos Eva , Oliveira Rui Caetano , Dede Kristòf , Kulka Janina , Borbala Székely , Salamon Ferenc , Madaras Lilla , Marcell Szasz A. , Lucidi Valerio , Meyer Yannick , Topal Baki , Verhoef Cornelis , Engstrand Jennie , Moro Carlos Fernandez , Gerling Marco , Bachir Imane , Biganzoli Elia , Donckier Vincent , Floris Giuseppe , Vermeulen Peter , Desmedt Christine 
Published: December 2023

AbstractLiver is the third most common organ for breast cancer (BC) metastasis. Two main histopathological growth patterns (HGP) exist in liver metastases (LM): desmoplastic and replacement. Although a reduced immunotherapy efficacy is reported in patients with LM, tumor-infiltrating lymphocytes (TIL) have not yet been investigated in BCLM. Here, we evaluate the distribution of the HGP and TIL in BCLM, and their association with clinicopathological variables and survival. We collect samples from surgically resected BCLM (n = 133 patients, 568 H&E sections) and post-mortem derived BCLM (n = 23 patients, 97 H&E sections). HGP is assessed as the proportion of tumor liver interface and categorized as pure-replacement (‘pure r-HGP’) or any-desmoplastic (‘any d-HGP’). We score the TIL according to LM-specific guidelines. Associations with progression-free (PFS) and overall survival (OS) are assessed using Cox regressions. We observe a higher prevalence of ‘any d-HGP’ (56%) in the surgical samples and a higher prevalence of ‘pure r-HGP’ (83%) in the post-mortem samples. In the surgical cohort, no evidence of the association between HGP and clinicopathological characteristics is observed except with the laterality of the primary tumor (p value = 0.049) and the systemic preoperative treatment before liver surgery (p value = .039). TIL is less prevalent in ‘pure r-HGP’ as compared to ‘any d-HGP’ (p value = 0.001). ‘Pure r-HGP’ predicts worse PFS (HR: 2.65; CI: (1.45–4.82); p value = 0.001) and OS (HR: 3.10; CI: (1.29–7.46); p value = 0.011) in the multivariable analyses. To conclude, we demonstrate that BCLM with a ‘pure r-HGP’ is associated with less TIL and with the worse outcome when compared with BCLM with ‘any d-HGP’. These findings suggest that HGP could be considered to refine treatment approaches.
Exploitable magnetic anisotropy and half-metallicity controls in multiferroic van der Waals heterostructure
Authors: Wang Yaping , Xu Xinguang , Ji Weixiao , Li Shengshi , Li Yanlu , Zhao Xian 
Published: December 2023

AbstractTwo-dimensional (2D) XY ferromagnets have drawn pronounced interest in recent years, but the characteristic of easy-plane magnetization restricts their application in spintronics to some extent. Here, we propose a general strategy for constructing multiferroic van der Waals heterostructures, aiming to achieve electrical control over the magnetic anisotropy in 2D XY ferromagnets. The validity of this strategy is verified by the heterostructure composed of ferromagnetic VBi2Te4 and ferroelectric In2Se3 monolayers. By manipulating the polarized states of In2Se3, the VBi2Te4 can be reversibly transformed between 2D XY and Heisenberg ferromagnets, characterized by the switching of easy magnetization axis between in-plane and out-of-plane directions. More interestingly, accompanied by the changes in magnetic anisotropy, the VBi2Te4 also demonstrates a phase transition from a semiconductor to a half-metal state, which can be ascribed to the band alignment and interfacial charge transfer. The switchable magnetic and electronic properties enable the heterostructure to be utilized in nonvolatile memory and logic devices. Additionally, the half-metallicity and magnetocrystalline anisotropy energy of the heterostructure can be effectively tuned by biaxial strain. These findings not only pave the way for electrically nonvolatile control of 2D XY ferromagnet, but also facilitate the development of interfacial magnetoelectric physics and applications.
Transcriptional profiling upon T cell stimulation reveals down-regulation of inflammatory pathways in T and B cells in SLE versus Sjögren’s syndrome
Authors: Kwon Gino , Wiedemann Annika , Steinheuer Lisa M. , Stefanski Ana-Luisa , Szelinski Franziska , Racek Tomas , Frei Andreas Philipp , Hatje Klas , Kam-Thong Tony , Schubert David , Schindler Thomas , Dörner Thomas , Thurley Kevin 
Published: December 2023

AbstractSystemic lupus erythematosus (SLE) and primary Sjögren’s syndrome (pSS) share clinical as well as pathogenic similarities. Although previous studies suggest various abnormalities in different immune cell compartments, dedicated cell-type specific transcriptomic signatures are often masked by patient heterogeneity. Here, we performed transcriptional profiling of isolated CD4, CD8, CD16 and CD19 lymphocytes from pSS and SLE patients upon T cell stimulation, in addition to a steady-state condition directly after blood drawing, in total comprising 581 sequencing samples. T cell stimulation, which induced a pronounced inflammatory response in all four cell types, gave rise to substantial re-modulation of lymphocyte subsets in the two autoimmune diseases compared to healthy controls, far exceeding the transcriptomic differences detected at steady-state. In particular, we detected cell-type and disease-specific down-regulation of a range of pro-inflammatory cytokine and chemokine pathways. Such differences between SLE and pSS patients are instrumental for selective immune targeting by future therapies.
Research on the causal mechanism of a rock burst accident in a longwall roadway and its prevention measures
Authors: Chen Ying , Zhang Zikai , Cao Chen , Bao Shiji , Wang Shuai , Xu Guangyuan 
Published: December 2023

AbstractBased on the disaster characteristics and the geo-conditions at the scene, in this study, the occurrence mechanism of a serious rock burst accident that occurred in the Tangshan Coal Mine, China, was analysed. Ground stress measurements showed that the mine is in a high ground stress area dominated by horizontal tectonic stress around 33 MPa. Laboratory testing revealed that the coal was a hard seam of 8.3 MPa over bedded by a thick and hard roof stratum with uniaxial compressive strength of 66 MPa. The calculation results indicated that the accident occurred in the roof rebounding area. It is proposed that the hard roof and the hard coal seam formed a seesaw structure around the working face. The vertical pressure relief caused the rib coal mass to lose its clamping forces from the roof and floor and rush into the roadway, resulting in a rock burst accident. Based on the causality mechanism of the rock burst disaster developed in this study, pertinent coal bump prevention measures have been undertaken in practice. Large-diameter boreholes were drilled to eliminate the pivot effect of the seam. Roof blasting was undertaken to prevent the roof from forming a seesaw plank. To summarize, a new causality mechanism for rock burst in coal mines under hard roof and hard seam geo-conditions was developed.
Ideological asymmetries in online hostility, intimidation, obscenity, and prejudice
Authors: Badaan Vivienne , Hoffarth Mark , Roper Caroline , Parker Taurean , Jost John T. 
Published: December 2023

AbstractTo investigate ideological symmetries and asymmetries in the expression of online prejudice, we used machine-learning methods to estimate the prevalence of extreme hostility in a large dataset of Twitter messages harvested in 2016. We analyzed language contained in 730,000 tweets on the following dimensions of bias: (1) threat and intimidation, (2) obscenity and vulgarity, (3) name-calling and humiliation, (4) hatred and/or racial, ethnic, or religious slurs, (5) stereotypical generalizations, and (6) negative prejudice. Results revealed that conservative social media users were significantly more likely than liberals to use language that involved threat, intimidation, name-calling, humiliation, stereotyping, and negative prejudice. Conservatives were also slightly more likely than liberals to use hateful language, but liberals were slightly more likely than conservatives to use obscenities. These findings are broadly consistent with the view that liberal values of equality and democratic tolerance contribute to ideological asymmetries in the expression of online prejudice, and they are inconsistent with the view that liberals and conservatives are equally prejudiced.
Atomic-scale view of the photoinduced structural transition to form sp3-like bonded order phase in graphite
Authors: Inami Eiichi , Nishioka Keita , Kanasaki Jun’ichi 
Published: December 2023

AbstractPhotoexcitation of solids often induces structural phase transitions between different ordered phases, some of which are unprecedented and thermodynamically inaccessible. The phenomenon, known as photoinduced structural phase transition (PSPT), is of significant interest to the technological progress of advanced materials processing and the fundamental understanding of material physics. Here, we applied scanning tunnelling microscopy (STM) to directly characterise the primary processes of the PSPT in graphite to form a sp3-like carbon nano-phase called diaphite. The primary challenge was to provide microscopic views of the graphite-to-diaphite transition. On an atomic scale, STM imaging of the photoexcited surface revealed the nucleation and proliferation processes of the diaphite phase; these were governed by the formation of sp3-like interlayer bonds. The growth mode of the diaphite phase depends strongly on the photon energy of excitation laser light. Different dynamical pathways were proposed to explain the formation of a sp3-like interlayer bonding. Potential mechanisms for photon-energy-dependent growth were examined based on the experimental and calculated results. The present results provide insight towards realising optical control of sp2-to-sp3 conversions and the organisation of nanoscale structures in graphene-related materials.
Contingent convertible bonds in financial networks
Authors: Calice Giovanni , Sala Carlo , Tantari Daniele 
Published: December 2023

AbstractWe study the role of contingent convertible bonds (CoCos) in a complex network of interconnected banks. By studying the system’s phase transitions, we reveal that the structure of the interbank network is of fundamental importance for the effectiveness of CoCos as a financial stability enhancing mechanism. Our results show that, under some network structures, the presence of CoCos can increase (and not reduce) financial fragility, because of the occurring of unneeded triggers and consequential suboptimal conversions that damage CoCos investors. We also demonstrate that, in the presence of a moderate financial shock, lightly interconnected financial networks are more robust than highly interconnected networks. This makes them a potentially optimal choice for both CoCos issuers and buyers.
Reward conditioning may not have an effect on category-specific memory
Authors: Sukumaran Priyanka , Kazanina Nina , Houghton Conor 
Published: December 2023

AbstractBehavioural tagging facilitates the temporary storage of seemingly insignificant episodic events, which may later become salient and enhanced in memory. Human behavioural studies have demonstrated selective memory enhancement for neutral stimuli from one category when this category is subsequently paired with reward. Although this phenomenon has implications for the role of reward conditioning on emotional and adaptive memory, its generalisability is underexplored. We conducted four experiments to investigate whether pairing items from a semantic category, animals or objects, with high or low rewards resulted in preferential memory for the high-reward category. Three of these experiments also aimed to replicate the category-specific retrospective enhancement effect reported by Patil et al. and two explored the corresponding prospective memory effect. None of our experiments showed consistent evidence for an effect of reward on category-specific memory enhancement, despite employing the same reward paradigm and incidental encoding protocol as in the original study. Consequently, we found no evidence for category-specific retrospective or prospective enhancement effects. Our experiments were conducted online which is an equally relevant method for assessing behavioural phenomenon as the in-person studies conducted by Patil et al. Overall, our results question the generalisability of previously reported category-specific memory enhancement effects due to reward.
Intensified discrimination against tenants and its health effects during the COVID-19 pandemic in large Chinese cities
Authors: Shan Lu , He Shenjing 
Published: December 2023

AbstractThe COVID-19 pandemic in many senses reconstructs social norms and reshapes social behaviour, which typically assumes a close correlation between mobility with a higher risk of COVID-19 infection. This may intensify the pre-existing discrimination against tenants and widen tenure-based health inequalities. Drawing on an online questionnaire survey conducted in five major cities in China in 2020, we employ multi-level regression models to examine the intensified discrimination against tenants during COVID-19 and its impacts on residents’ physical and mental health inequalities. Results show that the pre-existing inequalities have been intensified during COVID-19 and the perceived discrimination has rendered worsened self-rated health and mental health and enlarged health inequalities. The discrimination particularly affected tenants with better economic profiles or worse health conditions; by contrast, despite being exposed to more tenant-related discriminatory experiences, rural hukou holders suffered from less severe health inequalities. A clear linkage is found between renting in poorly-managed and larger health gaps generated by discrimination. The negative health impact of intensified discrimination is found to be more significant in communities with lower infection risk, which points to the necessity of understanding the long-term health impact of discrimination against tenants in a more holistic way. In terms of community environment, we discover a positive effect of community social capital, i.e., higher level social capital helps mitigate the health threat of discrimination against tenants during COVID-19. Besides, public housing tenants reported better health outcomes and were less exposed to intensified discrimination during COVID-19 than private housing tenants. These findings provide a nuanced understanding of variations determined by individual and territorial factors, thus present timely policy implications for promoting healthy and inclusive urban development in the post-pandemic era.