bluuebunny/crossref_metadata_2025_split huggingface dataset:
Effects of hemodialysis on hematological indices in Egyptian end-stage kidney disease patients
Authors: Madbouli Norhan N , Sheeba Mahmoud S , Rady Maha A A , Ghareeb Mohammed S 
Published: February 2024

Abstract

Background
Worldwide, chronic kidney disease is a serious health issue. Changes in erythrocyte morphology and function are induced by hemodialysis (HD), which affects the efflux of water over the membrane of erythrocytes.

Objective
This study aimed to demonstrate alterations in red cell indices and hematocrit (HCT) in chronic kidney disease patients receiving maintenance HD.

Patients and methods
The cross-sectional study consisted of 120 known end-stage kidney disease patients receiving maintenance HD at Ain Shams University Hospitals. Complete blood count by automated analyzer were used to compare blood counts before and after HD. Statistical approaches were used to examine the data (paired sample t test).

Results
There was a dramatic increase in HCT in the postdialysis state as opposed to the predialysis state HCT level (P<0.001). The change in HCT level is in a close proximity to and a good correlation with interdialytic weight gain and the duration of HD.

Conclusion
Important alterations in hematological parameters were observed in patients receiving maintenance HD, according to the findings of this study. Some of these changes can be attributed to ultrafiltration during session while others have yet to be explored.
Measurement of CD166 in Egyptian adult patients with acute lymphoblastic leukemia and its relation to clinical outcome
Authors: Fekry Gehad H , Atia Mona A M , Hassan Essam A , Mostafa Nevine N , EzzElarab Soha , Mohamed Eid Inas A M 
Published: February 2024

Abstract

Background
ALCAM (CD166) is a transmembrane; it has a role in the adhesion and binding of hematopoietic cells. It increases in different solid malignancies and hematological malignancies as multiple myeloma and acute leukemia. CD166 is considered one of the cancer stem cell markers responsible for most cancer recurrences following chemotherapy.

Aim
The study aimed to assess the expression of CD166 level in adult Egyptian acute lymphoblastic leukemia (ALL) patients, its correlation with disease-free survival, overall survival and relapse rate, as well as correlation with disease prognosis and response to treatment.

Patients and methods
This was a prospective cohort study conducted on 40 newly diagnosed ALL patients who will be recruited from the Clinical Hematology Department at Ain Shams University Hospital before initiation of chemotherapy in comparison to 15 patients in the control group.

Results
In comparison between newly diagnosed ALL patient initiation of chemotherapy and control groups, CD166 is elevated in ALL and has high sensitivity and specificity as a diagnostic and prognostic marker for ALL (P=0.000) and ALL patients with a high CD166 score have a higher overall survival rate.

Conclusion
ALL patients with a high CD166 score have a higher overall.
The catch in complete blood count when vitamin B12 deficiency is hiding behind microcytic anemia
Authors: Asif Muhammad , Siddiqui Saima , Dildar Shabnam , Ahmed Rehana , Shamsi Tahir 
Published: February 2024

Abstract

Background
Insufficient stores of vitamin B12 in human body are thought to result in macrocytic anemia. However, anemia in most of the patients is multifactorial. This is commonly owing to mixed nutritional deficiencies or bowel disorders affecting absorption of more than one element. Resultantly, a single causative agent of anemia like vitamin B12 deficiency may take macrocytic, normocytic, or microcytic forms. Patients presenting with microcytic anemia may have underlying insufficiency of this vitamin in some instances. Assessment of complete blood count (CBC) parameters may be helpful to identify such cases.

Methods
This study was conducted on 155 patients of microcytic anemia. Assessment of complete blood count (CBC) parameters and vitamin B12 was done using state of the art analyzers. The overall data was analyzed using SPSS version 23.

Results
Subnormal vitamin B12 levels were found in 17.4% of the studied cases. CBC parameters showed distinct changes in this group. Mean hemoglobin and red blood cell values were lower compared to the subjects having normal B12 values, and mean corpuscular volume and mean corpuscular hemoglobin concentration had an upward trend in cases of severe deficiency. Features of leucopenia and pancytopenia were more frequent also. Macrocytic red blood cells on peripheral smear were useful to detect the hidden deficiency even when the predominant picture consisted of microcytic cells.

Conclusions
Vitamin B12 deficiency maybe underlying in microcytic anemia patients. Important clues in CBC include very low hemoglobin but mildly decreased MCV values in the presence of leucopenia and macrocytic RBCs on peripheral smear.
Keratoconus characteristics and associations: A cross-sectional keratoconus study in western India (CKSWI)
Authors: Shah Zalak , Purohit Dipali , Danayak Parul 
Published: February 2024

Purpose:
To study the clinical and tomographic characteristics and associations of keratoconus (KC) patients visiting a tertiary eye care hospital.

Methods:
This was a cross-sectional, observational study that included 242 newly diagnosed clinical KC patients. Detailed ocular and systemic history, visual complaints, habit of eye rubbing, best spectacle-corrected visual acuity (BSCVA), retinoscopy reflex, detailed slit-lamp examination and tomographic findings, and presence of any ocular and systemic associations were documented for the included patients. Severity of KC was further graded into stages 0, 1, 2, 3, and 4 according to the ABCD grading system.

Results:
The most common visual complaint was blurred vision (82.64%), followed by itching (48.76%), tearing (43.80%), and photophobia (41.32%). A total of 44.62% of patients had the habit of eye rubbing and 4.54% had a family history of KC. Most common clinical signs were scissor reflex (94.21%), Rizutti’s sign (77.27%), corneal protrusion (69.83%), and Fleischer ring (67.35%). A total of 14.05% of patients had stage 0, 42.15% had stage 1, 19.83% had stage 2, 18.60% had stage 3, and 5.37% had stage 4 KC. Of these patients, 70.25% had a BSCVA visual acuity of ≥6/12 or better; 26.45% had a BSCVA of ≥6/60 to <6/12; and 3.30% had a BSCVA of <6/60. Ocular allergies, atopy, and asthma were found in 32.32%, 4.96%, and 2.48% cases, respectively.

Conclusion:
This study gives an overview of the clinical findings of KC cases in western India. Our results suggest that use of retinoscopy should be promoted in early KC detection in primary eyecare screening programs.
Clinical profile and management of ocular superglue injuries: Case series and review of literature
Authors: Malepati Nikhila , Sharma Supriya , Kate Anahita , Basu Sayan , Shanbhag Swapna S 
Published: February 2024

Purpose:
To describe the clinical profile and management of patients with ocular superglue injury (OSI).

Methods:
This retrospective study included all patients with OSI who presented at a tertiary eye care institute between 2016 and 2020. Data regarding demographics, clinical profile, and management were collected.

Results:
A total of 66 eyes of 58 patients (24 children, 34 adults) with a median age of 22.5 years [interquartile range (IQR): 11.3–31] were included. All cases sustained accidental injuries, with domestic injury at home being the most common location of injury among children (79%) and adults (53%) (P = 0.39). The median visual acuity at presentation was worse in children [0.3 logMAR (IQR: 0.2–0.4)] as compared to adults [0.1 logMAR (IQR: 0.1–0.3)] (P = 0.03)]. The most common clinical sign at presentation was conjunctival congestion in 77% of eyes (51/66) followed by polymerized glue stuck to the eyelashes and eyelids in 52% of eyes (34/66). The median duration from the time of injury to presentation was 2 hours in both groups. All eyes resolved with medical management. Examination under anesthesia was required in three children (13%) to evaluate the extent of OSI. None of the patients had long-term ocular complications.

Conclusion:
Improper and careless handling of superglue in the domestic setting may cause accidental ocular injuries that require immediate medical attention. OSI represents less severe ocular injuries that respond to medical therapy alone and is not associated with long-term visual morbidity. Modifications in the packaging of superglue containers and awareness about their deleterious effects could prevent these injuries.
A Mixed Method Assessment of the Fertility Preferences of Clients Using Antiretroviral Therapy in Ilorin, Nigeria – A Descriptive Cross-sectional Survey
Authors: Aderibigbe Adedayo Ayodele , Aderibigbe Sunday Adedeji , Akande Tanimola Makanjuola , Belabo Dooshima , Abiodun Joy , Alabi Seleem Babajide , Ahmed Abdullahi 
Published: February 2024

Abstract

Introduction:
The burden of human immunodeficiency virus (HIV)/acquired immunodeficiency syndrome in Nigeria remains one of the highest in the world, with the country having the highest number of people living with the infection in the West African subregion. Recent estimates put the HIV prevalence rate in Nigeria at 1.9%. In the early years of the HIV epidemic, attention on the reproductive preferences of people living with HIV was not really considered because of the high risk of mortality and few options to reduce mother-to-child transmission.

Methodology:
A descriptive cross-sectional study was carried out in November 2018 using quantitative and qualitative methods. A total of 400 participants were recruited for the quantitative part of the study and 10 respondents for each of the focus group discussion (FGD) sessions. Data were collected using an interviewer-administered questionnaire and a FGD guide. Frequencies and percentages were determined using descriptive analysis. Univariate analysis was used to explore the association between the outcome variables and the independent variables. The independent variables which showed a significant association in the univariate analysis were further subjected to multivariate analysis.

Results:
The desire to have children since their HIV diagnosis had been mooted by 255 (63.8%) respondents in the past and 64.5% of the respondents admitted to wanting to have children at some point in the future. More than half of the respondents (61%) currently wanted more children while a significant proportion of the respondents who wanted children (68.4%) wanted more than one child.

Conclusion:
The study observed that the desire to have children had largely not been affected by the HIV infection as respondents still had a fairly strong desire to continue to have more children in spite of the risks of transmission involved. The study recommended that government and HIV policymakers need to ensure that HIV prevention messages and programmes adopt cultural and socio-economic considerations when designing and planning HIV prevention programmes.
Human Papillomavirus Vaccination amongst Students in a Tertiary Institution in North Central Nigeria: A Cross-sectional Study on Sociodemographic Factors Associated with Its Awareness, Uptake and Willingness to Pay
Authors: Akande Oluwatosin Wuraola , Akande Tanimola Makanjuola 
Published: February 2024

Abstract

Background:
Human papillomavirus (HPV) vaccine is effective in averting 70%–90% of all HPV-related diseases. The assessment of its awareness, uptake and willingness to pay (WTP) is important in Nigeria which is one of the developing countries where more than three-quarter of the global burden of HPV-related diseases occur. This study aimed to determine the sociodemographic factors associated with the awareness, uptake and WTP for HPV vaccine amongst undergraduates in a tertiary institution in North Central Nigeria.

Methods:
This was a cross-sectional study. Data were collected from randomly sampled respondents through a validated self-administered questionnaire. Descriptive statistics, Chi-square and logistic regression analyses were applied to data collected to determine the awareness, uptake and WTP for HPV vaccine and their association with sociodemographic factors. The results of inferential statistics were considered significant when P < 0.05.

Results:
A total of 240 respondents were recruited, 15.4% of the respondents had heard about HPV vaccine, 2.1% of them had received at least a dose of the vaccine, 0.4% of them had completed three doses and 35.0% of them were willing to pay for it. Marital status (adjusted odds ratio [AOR]: 10.2; 95% confidence interval [CI]: 2.840–36.635) and parity (AOR: 5.8; 95% CI: 2.314–14.565) were predictors of WTP for the HPV vaccine.

Conclusion:
The evidence generated from this study suggests that there is a need to increase the awareness and uptake of the vaccine at the individual and population levels. The recent introduction of the HPV vaccine is a laudable step towards improving vaccine uptake. Public health authorities at the local, state and national levels should be empowered to develop tailored vaccine demand creation and advocacy strategies for HPV vaccine. Males should also be involved in the advocacy strategies and research on HPV vaccine.
Coronavirus Disease 2019 Vaccination Coverage and Seropositivity amongst Nigerians 18 Years Old and Above
Authors: Shuaib Faisal , Odusolu Yetunde , Okposen Bassey Bassey , Osibogun Opeyemi , Akanmu Sulaimon , Mohammed Abdullahi , Yahya Shuaib , Akande Tanimola , Aliyu Alhaji , Ifeadike Chigozie , Akande Aderonke , Aigbokhaode Adesuwa , Adebiyi Akin , Tobin-West Charles , Olatunya Oladele Simeon , Aguwa Emmanuel , Danjuma Garba , Dika Joseph , Nwosu Augustina , Olubodun Tope , Oladunjoye Adebimpe , Giwa Opeyemi , Osibogun Akin 
Published: February 2024

Abstract

Background:
This was a cross-sectional community-based survey to study the prevalence of serum antibodies against the severe acute respiratory syndrome coronavirus 1 (SARS-COV-1) and determine possible source of antibodies as to whether from vaccination or from natural infection as well as attempt to compare antibody levels in response to the different four types of vaccines administered in Nigeria.

Methods:
A cross-sectional community-based study of the prevalence of serum antibodies against all four vaccine types used in Nigeria amongst a representative sample of people aged 18 years and above in the six geopolitical zones of the country using a multistage sampling technique covering 12 states of the country with two states being randomly selected from each geopolitical zone. High-throughput Roche electrochemiluminescence immunoassay system (Elecsys Anti-SARS-COV-1 Cobas) was used for qualitative and quantitative detection of antibodies to SARS-COV-1 in human plasma.

Results:
There was no statistically significant difference between the proportions with seropositivity for both the vaccinated and the unvaccinated (P = 0.95). The nucleocapsid antibody (anti-Nc) titres were similar in both the vaccinated and the unvaccinated, whereas the Spike protein antibody (anti-S) titres were significantly higher amongst the vaccinated than amongst the unvaccinated. Antibody levels in subjects who received different vaccines were compared to provide information for policy.

Conclusion:
While only 45.9% of the subjects were reported to have been vaccinated, 98.7% of the subjects had had contact with the SARS-COV-1 as evidenced by the presence of nucleocapsid (NC) antibodies in their plasma. The 1.3% who had not been exposed to the virus, had spike protein antibodies which most likely resulted from vaccination in the absence of NC antibodies. Successive vaccination and booster doses either through heterogeneous or homologous vaccines increased antibody titres, and this stimulation of immune memory may offer greater protection against coronavirus disease 2019.
Effects of the MIND&GAIT physical exercise programme on depressive symptoms in institutionalised frail older adult: A Pilot Study
Authors: Couto Nuno , Silva Adriana , Duarte Francisca , Cid Luís , Bento Teresa , Santos Rocha Rita , Brito João , Vitorino Anabela 
Published: February 2024

The main purpose of this study was to analyse the effects of MIND&GAIT, a physical exercise programme, on depressive symptoms in frail institutionalised older people. Through a pilot study, thirty-five Portuguese frail older people (19 female, 16 male), with a mean age of 83.45 ± 9.73 years, participated in this study. The participants were randomly assigned into an experimental group (n = 19) and a control group (n = 16). Intervention was based on MIND&GAIT, physical exercise programme for frail older people. Depressive symptomatology was assessed using the Beck Depression Inventory (BDI-II) before and after 12 weeks of intervention. Results showed significant differences in depressive symptoms between the experimental group and the control group after the intervention. Depressive symptomatology decreased in the experimental group, while the participants in the control group had a significant increase in this indicator at the post-intervention moment. In general, the older people who were involved in the intervention group, improved their depressive symptoms, and the older who did not participate in the MIND&GAIT physical exercise programme, worsen this indicator. Considering the present results, we can conclude that this pilot study has presented initial findings that MIND&GAIT can contribute to improving depressive symptomatology in this population. This study has yielded essential data to construct subsequent randomized-controlled trials that can be effectively and feasibly executed within the community.
Keywords: physical exercise, depressive symptoms; frail older people
PEMBERDAYAAN MASYARAKAT DAN PENINGKATAN KUALITAS PEMBEAJARAN MELALUI PENIGKATAN BERWAWASAN KEBANGSAAN DAN KETERAMPILAN PRAKTIK PENGAJARAN DI LAEANSI FILIPINA
Authors: EIIi  , Satriani Is Sitti , Siti WaIidah Mustamin  , Mutahharah  , Hariansyah  , Iskandar  
Published: February 2024

setiap perguruan tinggi diharapkan dapat menghasilkan individu penerus bangsa yang berakhlak mulia, berbudi pekerti, tanggap, dan berintegritas yang mampu mengembangkan ilmu pengetahuan dan teknologi, sehingga bermanfaat bagi umat, bangsa dan negara. Dalam upaya untuk mencapai tujuan tersebut, setiap perguruan tinggi mmebekali mahasiswanya baik dengan pengetahuan teori maupun praktik. KKN Internasional Davao 2o22 mendapatkan kesempatan untuk terjun ke Desa Laensasi untuk melaksanakan beberapa program yang diharapkan dapat bermanfaat dan membantu masyarakat setempat. Sebagai saudara sebangsa, masalah-masalah yang dihadapi RIN menjadi alasan perlunya tim KKN diterjunkan untuk memberdayakan RIN. Program yang akan diberikan kepada masyarakat setempat dapat melatih keterampilan dan soft skill yang dibutuhkan, sehingga dapat memaksimalkan potensi yang dimiliki dan meningkatkan standar hidup mereka menjadi lebih baik lagiPada kesempatan kali ini, KKN Internasional Davao 2o22 mendapatkan kesempatan untuk terjun ke Desa Laensasi untuk melaksanakan beberapa program yang diharapkan dapat bermanfaat dan membantu masyarakat setempat. Sebagai saudara sebangsa, masalah-masalah yang dihadapi RIN menjadi alasan perlunya tim KKN diterjunkan untuk memberdayakan RIN. Program yang akan diberikan kepada masyarakat setempat dapat melatih keterampilan dan soft skill yang dibutuhkan, sehingga dapat memaksimalkan potensi yang dimiliki dan meningkatkan standar hidup mereka menjadi lebih baik lagi. Metode yang digunakan daIam program tersebut adaah Sosialisasi dan Observasi, edukasi, Demonstrasi, Pelatihan dan Praktik hasiI yang di dapatkan pada program tersebut adaIah pengenaan tentang bangsan indnesia, baik dari segi Bahasa, Iagu kebangsaan, Ietak geografis bangsa Indnesia, budaya bangsa Indnesia, memeriahkan hari kemerdekaan bangsa Indonesia dengan cara memberikan beberapa permainan/permaban khas dari Indonesia sebagai wujud cinta terhadap tanah air, Makanan Khas Bangsa Indnesia maupun pengenaan tentang A-Isam dan kemuhammadiyahan.
Les limitacions del principi d’autonomia en bioètica. Una reflexió des de la teoria republicana de la llibertat
Authors: Gómez Rincón José Francisco 
Published: February 2024

En aquest article pretenem fer una crítica, des de postulats ètics de caràcter republicà, al mode actual d’entendre i, per tant, posar en pràctica el principi d'autonomia de la bioètica. Pretenem mostrar que, en l’estat actual d’aplicació d'aquest principi, emprant una definició liberal de llibertat i de la natura humana, aquest idea de llibertat i autonomia que es pretén protegir, no es compleix en deixar fora de l’equació tot un seguit de circumstàncies socials, polítiques o econòmiques que poden dificultar al pacient prendre una veritable decisió sobirana sobre quin ha de ser el fet d'actuar dels professionals sanitaris sobre el seu cos en cada cas.
A 7-year record of vertical profiles of radar measurements and precipitation estimates at Dumont d'Urville, Adélie Land, East Antarctica
Authors: Wiener Valentin , Roussel Marie-Laure , Genthon Christophe , Vignon Étienne , Grazioli Jacopo , Berne Alexis 
Published: February 2024

Abstract. Studying precipitation falling over Antarctica is crucial as snowfall represents the main water input term for the polar cap. However, precipitation observations still remain scarce – and, more particularly, in the atmospheric column – due to numerous experimental issues related to the white continent. This paper aims at helping to close this observation gap by presenting 7 years of Micro Rain Radar (Metek MRR-2) data at the Dumont d'Urville station in coastal Adélie Land, East Antarctica. Statistics are calculated on three radar variables (equivalent reflectivity, mean Doppler velocity and signal-to-noise ratio (SNR)) to outline the main characteristics of the radar dataset. Seasonal and interannual variabilities are also investigated, but no significant temporal trends are detected, except for the seasonal mean Doppler velocity, which is higher in summer and lower in winter. We then use the snowfall rate (S) data from a collocated snow gauge to estimate the MRR precipitation profile from the radar equivalent reflectivity (Ze) through a locally derived Ze–S relation. We find the relation Ze=43.3S0.88. The processing method used to obtain this relation, data quality and uncertainty considerations are discussed in the paper. In order to give an example of application of the dataset, a brief statistical comparison of the MRR precipitation rate along the vertical with model data from the ERA5 reanalysis and the LMDZ climate model is performed, which notably shows that models underestimate heavy precipitation events. All datasets are available on the PANGAEA database with the associated DOI: https://doi.org/10.1594/PANGAEA.962727 (Wiener et al., 2023).
ANALISIS BEBAN KERJA GURU: STUDI KASUS MI AL ISLAM NGEMPLAK BOYOLALI
Authors: Hasanah Nur Iddha , Chusniyah Atin , Ibrahim Rustam 
Published: February 2024

Penelitian ini bertujuan untuk menganalisis beban kerja guru MI Al Islam Ngemplak Boyolali. Subjek utama dalam penelitian ini adalah pengurus Yayasan, Kepala Madrasah, dan guru di MI Al Islam Ngemplak Boyolali. Teknik pengumpulan data dilakukan dengan cara wawancara, observasi, dan analisis dokumen. Teknik analisis data yang digunakan yaitu reduksi data, penyajian data dan penarikan kesimpulan/verifikasi. Hasil penelitian ini menunjukkan rata-rata guru di MI Al Islam Ngemplak memiliki kelebihan beban jam kerja antara 2,5 hingga 7,5 jam/minggu. Faktor-faktor yang menyebabkan hal tersebut antara lain pendapatan madrasah yang terbatas, kurangnya tenaga pendidikan, dan tidak sesuainya kualifikasi pendidik dengan jurusan yang diampunya. Rekomendasi kebijakan yang dapat diambil antara lain meningkatkan pendapatan madrasah, menambah tenaga kependidikan, dan meningkatkan kualitas guru melalui pengembangan profesionalisme guru.