bluuebunny/crossref_metadata_2025_split huggingface dataset:
Boosting Multi-Label Classification Performance Through Meta-Model
Authors: Guehria Sonia , Belleili Habiba , Azizi Nabiha , Zenakhra Djamel 
Published: December 2023

Multi-label classification problem, where each instance can be associated with multiple labels, has received considerable attention from machine learning community. To address the inherent challenges of multi-label classification including data imbalance, label dependence, and high dimensionality, ensemble approaches have been developed, gaining popularity across various real-world applications. This paper proposes a novel ensemble method called ConfBoost that addresses these challenges and enhances the generalization ability of learning systems. ConfBoost which is a meta-model based on a weighted stacking paradigm using local confidence, combines heterogeneous and complementary ensembles of multi-label classifiers. The proposed approach achieves two main objectives: Firstly, by focusing on label weights based on their confidence scores, the model can generate more relevant predictions and enhance the accuracy at the base-level by mitigating the impact of irrelevant labels during the stacking process. Moreover, assigning higher weights to certain labels exhibits better discrimination and adaptability to capture complex label relationships. Second, applying adjusted thresholds enables the model to generate predictions adapted to the specific characteristics of each label, effectively addressing imbalanced label distributions. Extensive experiments on publicly available datasets demonstrate that ConfBoost outperforms conventional combination methods and consistently surpasses related state-of-the-art methods. These findings highlight the effectiveness and potential of ConfBoost as an advanced ensemble method for multi-label classification tasks.
International Trade Friction and Firm Disclosure Tone: Evidence from China
Authors: Xu Haoran , Wu Yongliang , Zhang Min 
Published: December 2023

Synopsis The research problem This study examines whether international trade friction has an impact on firm disclosure tone. Motivation The past two decades have witnessed a large amount of trade friction worldwide. Under this background, the impact of trade friction on microenterprises is of great concern to researchers. Previous studies have shown that trade friction is related to firm operating or financial activities such as performance, investment, stock prices, loan financing, and employment. However, there are no published papers about how trade friction impacts the disclosure behaviors of firms subject to the friction. This study attempts to fill this void by investigating whether firms manage disclosure tone when they are subject to trade friction. The test hypotheses We test two competing hypotheses in this study. Our first hypothesis is that firms impacted by trade friction increase the positive tone of their information disclosure. Second, firms impacted by trade friction decrease the positive tone of their information disclosure. Target population This study should be of interest to firm managers, investors, creditors, and policy makers. Adopted methodology Ordinary least squares regressions and archival data. Analyses We conducted this study by using a sample of listed firms in China. Over the past two decades, China has been the world’s largest country subject to trade frictions. In addition, China’s weak institutional environment and language habit provide an ideal setting for this study. Firm disclosure tone is measured as the frequency difference between the positive and negative words scaled by total words in an annual report. We tested whether there is a positive/negative association between trade friction and firm disclosure tone. Findings We find that firms strategically increase their positive tone in annual reports when they are subject to trade friction. Further analyses reveal that the impact of trade friction on disclosure tone is more pronounced for smaller firms, firms with more financial constraints, and firms with less analyst following. In addition, this impact is attenuated when firms have stronger corporate governance. Finally, we show that using more positive tones help firms subject to trade friction improve short-term market valuation, obtain more bank loans, and have lower cost of debt.
Aneuploidy Landscape in Precursors of Ovarian Cancer
Authors: Wang Yeh , Douville Christopher , Chien Yen-Wei , Wang Brant G. , Chen Chi-Long , Pinto Andre , Smith Saron Ann , Drapkin Ronny , Chui M. Herman , Numan Tricia , Vang Russell , Papadopoulos Nickolas , Wang Tian-Li , Shih Ie-Ming 
Published: December 2023

Abstract

Purpose:
Serous tubal intraepithelial carcinoma (STIC) is now recognized as the main precursor of ovarian high-grade serous carcinoma (HGSC). Other potential tubal lesions include p53 signatures and tubal intraepithelial lesions. We aimed to investigate the extent and pattern of aneuploidy in these epithelial lesions and HGSC to define the features that characterize stages of tumor initiation and progression.

Experimental Design:
We applied RealSeqS to compare genome-wide aneuploidy patterns among the precursors, HGSC (cases, n = 85), and histologically unremarkable fallopian tube epithelium (HU-FTE; control, n = 65). On the basis of a discovery set (n = 67), we developed an aneuploidy-based algorithm, REAL-FAST (Repetitive Element AneupLoidy Sequencing Fallopian Tube Aneuploidy in STIC), to correlate the molecular data with pathology diagnoses. We validated the result in an independent validation set (n = 83) to determine its performance. We correlated the molecularly defined precursor subgroups with proliferative activity and histology.

Results:
We found that nearly all p53 signatures lost the entire Chr17, offering a “two-hit” mechanism involving both TP53 and BRCA1 in BRCA1 germline mutation carriers. Proliferatively active STICs harbor gains of 19q12 (CCNE1), 19q13.2, 8q24 (MYC), or 8q arm, whereas proliferatively dormant STICs show 22q loss. REAL-FAST classified HU-FTE and STICs into 5 clusters and identified a STIC subgroup harboring unique aneuploidy that is associated with increased proliferation and discohesive growth. On the basis of a validation set, REAL-FAST showed 95.8% sensitivity and 97.1% specificity in detecting STIC/HGSC.

Conclusions:
Morphologically similar STICs are molecularly distinct. The REAL-FAST assay identifies a potentially “aggressive” STIC subgroup harboring unique DNA aneuploidy that is associated with increased cellular proliferation and discohesive growth. REAL-FAST offers a highly reproducible adjunct technique to assist the diagnosis of STIC lesions.
Backfilling Patients in Phase I Dose-Escalation Trials Using Bayesian Optimal Interval Design (BOIN)
Authors: Zhao Yixuan , Yuan Ying , Korn Edward L. , Freidlin Boris 
Published: December 2023

Abstract
In recent years, there has been increased interest in incorporation of backfilling into dose-escalation clinical trials, which involves concurrently assigning patients to doses that have been previously cleared for safety by the dose-escalation design. Backfilling generates additional information on safety, tolerability, and preliminary activity on a range of doses below the maximum tolerated dose (MTD), which is relevant for selection of the recommended phase II dose and dose optimization. However, in practice, backfilling may not be rigorously defined in trial protocols and implemented consistently. Furthermore, backfilling designs require careful planning to minimize the probability of treating additional patients with potentially inactive agents (and/or subtherapeutic doses). In this paper, we propose a simple and principled approach to incorporate backfilling into the Bayesian optimal interval design (BOIN). The design integrates data from the dose-escalation and backfilling components of the design and ensures that the additional patients are treated at doses where some activity has been seen. Simulation studies demonstrated that the proposed backfilling BOIN design (BF-BOIN) generates additional data for future dose optimization, maintains the accuracy of the MTD identification, and improves patient safety without prolonging the trial duration.
The Influence of Interpersonal Skills of Working Students on Client Service Satisfaction in a Higher Educational Institution
Authors: Abejo Chaldea G. , Adanza Diosa Ruby Anne G. , Salvador Haniza N. , Uy Mary Niña J. , Indoc Sheila Mae P. , Abiol Michael Jere’ D. 
Published: December 2023

The research aimed to investigate the impact of working students' interpersonal skills on client service satisfaction in a higher education institution on Sabayle Street, Iligan City. The study, conducted in 2022, included 50 respondents to accomplish its objectives. Stratified random sampling was employed to assess the interpersonal skills of the respondents. The study's findings concluded that clients expressed a high level of satisfaction with the services they received, indicating a significant positive relationship between clients and working students. The research strongly recommended that both working students and their clients recognize and support this positive dynamic to strengthen their relationship further.
Additionally, it encouraged the provision of constructive feedback on how working students interacted with their clients at St. Peter's College on Sabayle Street in Iligan City. In summary, this study shed light on the positive impact of working students' interpersonal skills on client service satisfaction. Acknowledging and nurturing this relationship was crucial for both parties involved, fostering an environment of mutual support and growth. Additionally, offering constructive feedback further enhances the quality of interactions between working students and clients in the academic setting.
The Mediating Effect of Organizational Culture on the Relationship Between Organizational Commitment and Work-life Balance Among Business Management Faculty
Authors: Sabuero Jimmy B. 
Published: December 2023

Work-life balance involves work and family. Work's great obligations require time for friends, family, civic activity, personal growth, self-care, and other personal pursuits. This study aimed to determine the mediating effect of organizational culture on the relationship between organizational commitment and work-life balance among business management faculty. This study used a descriptive correlational research design with mediation analysis. Stratified Random sampling was used with a total sample size of 130 respondents. Data were analyzed through descriptive and inferential statistics using mean and standard deviation. The inferential statistics, Pearson R was used to test the significant relationship, while mediation analysis was used to determine the effect of organizational culture on the relationship between organizational commitment and work-life balance.
The findings reveal that the overall mean of faculty’s organizational commitment is (X̄=3.34, SD=0.59), interpreted as "Very high commitment". The study revealed that the overall mean work-life balance of the respondents is (X̄=3.42, SD=0.72), interpreted as a "Very high work-life balance." While the overall mean of faculty's organizational culture is (X̄=3.41, SD=0.51) interpreted “Very high organizational culture". The study showed a significant relationship between work-life balance and organizational commitment (r=0.785; p=.00), in which faculty who have high organizational commitment tend to have high work-life balance. The study also showed that there is a significant relationship between organizational culture and organizational commitment (r=0.716; p=.00) in which faculty who rated high organizational culture tend to have high organizational commitment. Moreover, there is a significant relationship between organizational culture and Work-life balance (r=.582; p=.00), of which faculty who have rated high organizational culture tend to have high work-life balance. However, organizational culture does not significantly mediate the relationship between organizational commitment and work-life balance among business management faculty. Thus, it rejected the null hypothesis.
It can be concluded that commitment serves as a driving force in all organizational and institutional dealings. Faculty with a high organizational commitment tend to have high ratings on their measure of work-life balance. The Spillover Theory of Wilensky also proved in this study that Work-life Balance can impact one's emotions, motivation, and behavior in another area, leading to a ripple effect or spillover.
Evaluation of Job Satisfaction and Retention of Female Uniformed Personnel at The Civil Relations Service as A Result of Gender-Responsive Programs
Authors: Angulo Portia S. , Beloro Riza O. , Cruz Hernando A. , Quimson Jennifer S. 
Published: December 2023

This research paper aims to measure the job satisfaction of female uniformed personnel and determine whether Gender and Development (GAD) policies and programs affect their retirement plans in military service. Moreover, it seeks to identify courses of action that could be implemented in the organization to further strengthen its GAD policies and programs.
This study used a descriptive method for research with the assistance of a questionnaire as the main tool to gather data from the respondents. To examine the data, frequency distribution was used to determine the demographic profile of the respondents; Weighted Mean was used to assess the implementation and effectiveness of GAD programs and initiatives within the organization as well as to assess the job satisfaction on the promotion of women empowerment and participation; and Spearman Rank Correlation was used to measure the association between the level of satisfaction of female soldiers across age, rank, and civil status in terms of retention.
Based on the result of the study, the implemented GAD policies and programs in the Civil Relations Service (CRS) significantly impact the retention of uniformed women and effectively address gender-related issues affecting women in the service. Furthermore, the study reveals that female uniformed personnel's satisfaction with the promotion of women empowerment and participation is a critical factor affecting their retention intentions.
The researchers recommend that the organization develop policies and initiatives more responsive to the demands of the CRS female soldier. It's necessary to carry out a gender audit to determine the overall structure of the institution.
The Impact of COVID-19 Pandemic on the Mental Health of 3rd-Year Medical Technology Students in a University in Manila, Philippines A.Y. 2022-2023
Authors: Malang Emmanuel DS , De Guzman Angela Marie A. , Dizon Sally Nicoile S. , Garcia Katrene Marie M. , Garcia Krishia Marie M. , Gogolin Penelope Portia P 
Published: December 2023

Having good mental health is crucial throughout one's entire life, starting from early stages like childhood and adolescence, and continuing through adulthood and beyond. This research is a quantitative research approach and a correlational research design that aims to conduct a survey to assess the impact of the COVID-19 pandemic on the Mental Health of 3rd-Year Medical Technology College Students in a University in Manila. The researchers conducted an online survey consisting of 3rd-year medical technology students which has 317 as the overall population and 174 as respondents and were computed using an online statistical program, Raosoft. The online survey is only accessible to 3rd-year college students under the Department of Medical Technology at a University in Manila, Philippines. The tallied data is stored via google sheets. This data is analyzed using the SPSS statistical tool. The results of the computations on the gathered data showed a significant relationship between the respondents’ understanding of COVID-19 and their psychological/mental health status. Consequently, this research study is helpful and beneficial to the students by helping them in gathering more knowledge about COVID-19 and helping them to control mental health problems in a more efficient way. The results show that the COVID-19 pandemic has both positive and negative impacts on the mental health of students in general. For instance, in positive impact, the majority of students feel at least moderately confident in their ability to manage personal challenges. In negative impact, students sometimes feel that they are unable to control important things in their life.
Engagement and Learning Success: Evidence from Three Years of Transformational Teaching Strategies in Online Event Marketing Education
Authors: Vergara Kimberly Christie , Santos Joseph Emil , Blasa-Cheng Angelique , Balatbat Maricel , Vergara Raymond Allan 
Published: December 2023

This study is part of an ongoing teacher-led initiative in understanding the co-creation of a transformative learning experience in the online event marketing classroom. The study measures the impact of student engagement on student-defined learning success in online learning. Using a mixed methods approach, it investigates data collected through a survey questionnaire in three different years from students who enrolled in two course subjects.
This study demonstrates that student engagement is significantly correlated with and predicts learner-defined learning success in online learning. Furthermore, it finds that there were statistically significant differences in levels of student engagement and learning success among different cohorts, particularly when compared to cohorts who took the course subject in the later year. The differences may have been a result of the development of skills appropriate for online learning, and in improvements in course content and delivery.
CD4+ T-Cell Legumain Deficiency Attenuates Hypertensive Damage via Preservation of TRAF6
Authors: He Yuhu , Zou Pu , Lu Junmi , Lu Yufei , Yuan Shuguang , Zheng Xialei , Liu Jing , Zeng Cheng , Liu Ling , Tang Liang , Fang Zhenfei , Hu Xinqun , Liu Qiming , Zhou Shenghua 
Published: December 2023

BACKGROUND:
T cells are central to the immune responses contributing to hypertension. LGMN (legumain) is highly expressed in T cells; however, its role in the pathogenesis of hypertension remains unclear.

METHODS:

Peripheral blood samples were collected from patients with hypertension, and cluster of differentiation (CD)4+ T cells were sorted for gene expression and Western blotting analysis. TLGMNKO (T cell–specific LGMN-knockout) mice (Lgmn
f/f
/CD4
Cre
), regulatory T cell (Treg)–specific LGMN-knockout mice (Lgmn
f/f
/Foxp3
YFP Cre
), and RR-11a (LGMN inhibitor)–treated C57BL/6 mice were infused with Ang II (angiotensin II) or deoxycorticosterone acetate/salt to establish hypertensive animal models. Flow cytometry, 4-dimensional label-free proteomics, coimmunoprecipitation, Treg suppression, and in vivo Treg depletion or adoptive transfer were used to delineate the functional importance of T-cell LGMN in hypertension development.

RESULTS:
LGMN mRNA expression was increased in CD4+ T cells isolated from hypertensive patients and mice, was positively correlated with both systolic and diastolic blood pressure, and was negatively correlated with serum IL (interleukin)-10 levels. TLGMNKO mice exhibited reduced Ang II–induced or deoxycorticosterone acetate/salt–induced hypertension and target organ damage relative to wild-type (WT) mice. Genetic and pharmacological inhibition of LGMN blocked Ang II–induced or deoxycorticosterone acetate/salt–induced immunoinhibitory Treg reduction in the kidneys and blood. Anti-CD25 antibody depletion of Tregs abolished the protective effects against Ang II–induced hypertension in TLGMNKO mice, and LGMN deletion in Tregs prevented Ang II–induced hypertension in mice. Mechanistically, endogenous LGMN impaired Treg differentiation and function by directly interacting with and facilitating the degradation of TRAF6 (tumor necrosis factor receptor–associated factor 6) via chaperone-mediated autophagy, thereby inhibiting NF-κB (nuclear factor kappa B) activation. Adoptive transfer of LGMN-deficient Tregs reversed Ang II–induced hypertension, whereas depletion of TRAF6 in LGMN-deficient Tregs blocked the protective effects.

CONCLUSIONS:
LGMN deficiency in T cells prevents hypertension and its complications by promoting Treg differentiation and function. Specifically targeting LGMN in Tregs may be an innovative approach for hypertension treatment.
Role of Polyunsaturated Fat in Modifying Cardiovascular Risk Associated With Family History of Cardiovascular Disease: Pooled De Novo Results From 15 Observational Studies
Authors: Laguzzi Federica , Åkesson Agneta , Marklund Matti , Qian Frank , Gigante Bruna , Bartz Traci M. , Bassett Julie K. , Birukov Anna , Campos Hannia , Hirakawa Yoichiro , Imamura Fumiaki , Jäger Susanne , Lankinen Maria , Murphy Rachel A. , Senn Mackenzie , Tanaka Toshiko , Tintle Nathan , Virtanen Jyrki K. , Yamagishi Kazumasa , Allison Matthew , Brouwer Ingeborg A. , De Faire Ulf , Eiriksdottir Gudny. , Ferrucci Luigi , Forouhi Nita G. , Geleijnse Johanna M. , Hodge Allison M , Kimura Hitomi , Laakso Markku , Risérus Ulf , van Westing Anniek C. , Bandinelli Stefania , Baylin Ana , Giles Graham G. , Gudnason Vilmundur , Iso Hiroyasu , Lemaitre Rozenn N. , Ninomiya Toshiharu , Post Wendy S. , Psaty Bruce M. , Salonen Jukka T. , Schulze Matthias B. , Tsai Michael Y. , Uusitupa Matti , Wareham Nicholas J. , Oh Seung-Won , Wood Alexis C. , Harris William S. , Siscovick David , Mozaffarian Dariush , Leander Karin ,   Fatty Acids and Outcomes Research Consortium (FORCE)
Published: December 2023

BACKGROUND:
It is unknown whether dietary intake of polyunsaturated fatty acids (PUFA) modifies the cardiovascular disease (CVD) risk associated with a family history of CVD. We assessed interactions between biomarkers of low PUFA intake and a family history in relation to long-term CVD risk in a large consortium.

METHODS:
Blood and tissue PUFA data from 40 885 CVD-free adults were assessed. PUFA levels ≤25th percentile were considered to reflect low intake of linoleic, alpha-linolenic, and eicosapentaenoic/docosahexaenoic acids (EPA/DHA). Family history was defined as having ≥1 first-degree relative who experienced a CVD event. Relative risks with 95% CI of CVD were estimated using Cox regression and meta-analyzed. Interactions were assessed by analyzing product terms and calculating relative excess risk due to interaction.

RESULTS:

After multivariable adjustments, a significant interaction between low EPA/DHA and family history was observed (product term pooled RR, 1.09 [95% CI, 1.02–1.16];
P
=0.01). The pooled relative risk of CVD associated with the combined exposure to low EPA/DHA, and family history was 1.41 (95% CI, 1.30–1.54), whereas it was 1.25 (95% CI, 1.16–1.33) for family history alone and 1.06 (95% CI, 0.98–1.14) for EPA/DHA alone, compared with those with neither exposure. The relative excess risk due to interaction results indicated no interactions.

CONCLUSIONS:
A significant interaction between biomarkers of low EPA/DHA intake, but not the other PUFA, and a family history was observed. This novel finding might suggest a need to emphasize the benefit of consuming oily fish for individuals with a family history of CVD.