bluuebunny/crossref_metadata_2025_split huggingface dataset:
Glycogen Storage Disease Type III Presenting as Recurrent Seizure Disorder in a Second Twin: A Case Report
Authors: Jahun Mahmud Gambo , Umar Umar Isa 
Published: October 2023

Glycogen storage diseases (GSDs) are a group of genetic autosomal recessive metabolic disorders resulting from deficiencies of enzymes of glycogen metabolism occurring in the liver, muscles or kidneys. Various types and sub-types exist based on genetic classification presenting with symptoms and signs of hypoglycaemia, hepatomegaly and myopathy depending on severity, and age of onset. A high index of suspicion is required for the diagnosis of GSDs. An eighteen-month-old girl who was apparently healthy with normal development was without any abnormality until about 12 months of age when she had the first episode of afebrile seizure which was treated with sodium valproate but continued to have occasional seizures. She had a status seizure, which was only aborted with a glucose infusion. Intra-ictal incident glucose level was 1.4mmol/L. Biochemical investigation revealed deranged liver enzymes, normal serum cortisol, C-peptide and insulin. Liver histology showed features consistent with GSD III and diagnosis of glycogen storage disease type III was made based on the liver histology and other supportive laboratory features. Following dietary management, the child responded very well, was seizure-free and off anticonvulsant therapy. This case highlights the occurrence of symptomatic seizures due to factors other than epilepsy.
Sustainable Construction Understanding among Architecture, Engineering and Construction (AEC) Professionals in Abuja
Authors: Muhammad-Jamil A. , Galadima A.S. , Bandi S. , NorHazren I.M. 
Published: October 2023

Globally, there is a growing desire to deliver sustainable infrastructure projects. However, the implementation of sustainable construction in Nigeria is still in its early stages. It is believed that the successful adoption of sustainable construction in Nigeria depends, in part, on the understanding of sustainable construction among professionals in the architecture, engineering, and construction (AEC) industry. This study argues that the extent to which AEC professionals demonstrate a clear understanding of sustainable construction reflects their knowledge and provides a starting point for effective implementation in the future. By focusing on the current efforts of the Nigerian AEC industry to embrace sustainability, this study aims to identify key factors that exemplify the understanding of sustainable construction among professionals. A survey was conducted among 290 registered construction professionals in Abuja. The data was analysed using factor analysis and partial least squares structural equation modelling (PLS-SEM) approach. The result from the analysis shows seven factors: awareness, political factors, passive culture, knowledge, demand, financial, and attitude. These factors characterise sustainable construction practices understanding among AEC professionals in Abuja. This serves as a foundation for future implementation of sustainable construction practices in Nigeria in line with the views of many sustainable construction researchers.
Implications of Housing Corporations’ Capacity on Successful Delivery of Mass Housing Programmes
Authors: Dodo M. , Abdulrahman R.S. , Ishaq Z.H. , Ibrahim A.D. 
Published: October 2023

There has been several ambitious housing policies in Nigeria spanning across pre and post-independence aimed at addressing the growing housing deficit using the concept of Mass Housing Programmes (MHPs), including the recent MHPs in the Nigerian Economic Sustainability Plan- (NESP) (2021-2025). However, implementation of the policies has not addressed the housing deficit because records confirmed the low performances of MHPs whereby only a fraction of the units intended to be built are delivered. The strategy for implementing the MHP is that, implementation institutions are to utilise Estate Developers (EDs) such as Housing Corporations (HCs) to drive the successful execution of the projects and based on the scale of the MHP in the NESP, the capacity of EDs in general and HCs specifically will have implications on its success. As such, this study was designed to ascertain the implications of HCs capacity towards successful delivery of MHPs in Nigeria. A Case Study Research design was used to collect data from HCs of six North-West states in Nigeria using an interview. Data was analysed using a single case and crosscase technique. Results revealed that the experiences in the practices of HCs in MHPs has the potentials to: reduce project cost; reduce project time; increase clients’ satisfaction; and develop human resource. It was concluded that the HCs in North-West States possess capacity to successfully deliver MHPs such as the NESP and future National Housing Programmes (NHPs). Based on the findings of this research, the study recommends that the vulnerability of HCs should be studied to get a more encompassing picture of performance potentials in successfully delivering MHPs. Furthermore, a more comprehensive study should be undertaken to cover the HCs across Nigeria to get information that could enable their optimal integration into MHPs. The implication of the findings is that, since the HCs demonstrated some capacities to deliver MHPs, EDs can successfully delivered MHPs if other enabling factors that are key to delivery of MHPs such as finance, among others are put in place. The limitation of the study is that the study covers only six HCs, thus, generalisation of the findings could be limited.
Kenya Medical Training College laboratory student perception on adequacy of teaching and learning resources in the advent of COVID-19
Authors: Kondo Benson Mbati , Kang’ethe Simon , Ngeno Anne 
Published: October 2023

The emergence of COVID-19 presented a big challenge in medical education, especially with regard to the adequacy of teaching and learning resources. In addition, an increase in student intake and demand for Kenya Medical Training College courses could compromise these resources. This study investigated the perceptions of students towards the adequacy of teaching and learning resources at Kenya Medical Training College in the advent of COVID-19. The general objective was to determine the perceived adequacy of teaching and learning resources in the advent of COVID-19 by students in the department of Medical Laboratory Sciences at Kenya Medical Training College. A descriptive cross-sectional study design using mixed methods (triangulation) was used. Simple random sampling of the eight regions in the country was used to select one region (the Eastern Region). Census sampling was used to select all the four campuses in the region namely Machakos, Meru, Embu, and Kitui, which offer medical laboratory sciences. The study population was students in the department of medical laboratory sciences on these campuses, with 220 students participating. The data collection instrument was a self- administered closed- and open-ended questionnaires. Quantitative data collected was analysed using SPSS software, while qualitative data was analysed using themes. The response rate was 100% (220 students). The gender distribution among students showed a higher percentage in male (58%). Majority of the students were 21-23 years (35%). One-way ANOVA presented a statistically significance between and within groups (P<0.05). Majority of students (51.8%) were not satisfied with adequacy of human resources. Majority of students perceived the state of physical facilities to be in poor state with a mean of 1.76, while the satisfaction level of majority of students’ on teaching aids was below 3.40 representing very inadequate to neutral. Ordinal regression tests on satisfaction level on teaching aids in relation to gender, year of study and campus was significant (chi-square test p<0.000) while the goodness of fit model was (p=1.000) indicating it was a good model. R^2 value (Nagelkerke=99%) indicated that the study factors had great variations. The spearman’s rank test showed that laboratory equipment and computer assisted aids, internet, learning systems have negative correlation but with very strong coefficient correlation of 1.0000. Satisfaction levels with teaching aids in relation to gender, year of study, and campus were significant with a chi-square test of P < 0.000. The study concluded that there were inadequate teaching and learning resources on the four KMTC campuses before COVID-19.
Environmental Pollution and Climate Change: An Ethical Evaluation of the Carbon Tax Policy in South Africa
Authors: Masondo Zama Nonkululeko , Nwosimiri Ovett 
Published: October 2023

Environmental pollution and climate change have been considered the main environmental challenges affecting the world’s ecosystem, including that of South Africa. They cause poverty, land degradation, and health hazards. One of the leading causes and contributing factors of environmental pollution and climate change is carbon emissions into the atmosphere. As a way to curb these emissions, Carbon tax policy has been introduced in various countries, including South Africa. In 2019, a Carbon tax was introduced to assist South Africa in delivering on the commitments made in the Paris Agreement in 2015. If the policy is effectively applied, it will raise revenues while reducing carbon dioxide emissions. Before and after introducing the Carbon tax policy in South Africa, there has been debate and discussion on its impact on the environment, economy, and society. Based on the debate and discussion, it has been observed that more attention is paid to the economic implications and benefits of the tax on South Africa than the ethical implications. Thus, this paper aims to contribute to the ongoing debate and discussion by ethically evaluating the Carbon tax policy in South Africa.
A UV Spectrophotometric method for simultaneous determination of Ibuprofen and Paracetamol concentration in suspensions
Authors: Mugwiza E. , Hahirwa I. , Umumararungu T. 
Published: October 2023

INTRODUCTION: Paracetamol is a standard antipyretic and analgesic which is widely used since the 19th century. Currently, paracetamol is the first-line treatment for pain management of different types. Ibuprofen, on the other hand, is an antipyretic and an analgesic. It is safe and has been used in the treatment of a number of conditions including mild to moderate pain, dysmenorrhea, inflammations and fever to name few.
METHODS: This study aimed at developing and validating a simultaneous UV spectrophotometric method for analysis of ibuprofen and paracetamol in fixed-dose combination suspensions. The proposed method is based on the simultaneous equation principle, which involves measurement of absorbance at wavelengths of maximum absorbance for ibuprofen and paracetamol. The method was validated for linearity, accuracy, repeatability, intermediate precision and robustness as per USP and ICH guidelines.
RESULTS: The two molecules showed wavelength of maximum absorbance at 222 nm and 243 nm for ibuprofen and paracetamol respectively, using phosphate buffer as a diluent. The method was also linear (R2≥0.995), precise (RSD ≤ 2), and robust with accuracy ranging between 98.1%-105% and 109.8 %- 134.9% for paracetamol and ibuprofen, in the range of 0.0032 – 0.0048 mg/ml for ibuprofen and 0.004-0.006 mg/ml for paracetamol, respectively.
CONCLUSION: We have developed an accurate and robust method which can be used to analyze quantitatively paracetamol in suspensions which contain both paracetamol and ibuprofen. The limits of quantification of this method cover the concentration range recommended by the USP (80%- 120%), which justifies the application of the method in routine analysis.
An Efficient Derivative Free Iterative Method and Condition Number of Nonlinear Equations Arising from Real World Phenomena
Authors: Nguni Alatuhigha , Chacha Chacha S. , Mtunya Adeline P. 
Published: October 2023

Recent researches have shown a great interest in developing novel numerical methods for solving nonlinear equations of the form arising from real world phenomena. However, very little attention has been given to the study of condition numbers which is an important aspect in measuring the sensitivity of the problem in response to slight perturbations in the input data. In this article, we present an efficient free derivative iterative scheme constructed by refining Newton-Raphson method standard form in which the derivative term is approximated by using finite difference scheme; hence making it derivative free. We also conducted an in-depth analysis of the condition numbers to explore sensitivity and efficiency comparisons between the proposed algorithm and existing methods for the given problems. Our investigation focused on iteration numbers, residuals, and convergence under mild error tolerances. Based on five numerical case studies, results revealed that the proposed Algorithm 2 outperforms the existing Algorithm 1 in terms of accuracy of the approximate solution. The results for the condition numbers indicated that all problems considered were ill-conditioned, highlighting the significance of studying condition numbers in the context of solving nonlinear equations.
ANALISA KUAT TEKAN BETON NORMAL DENGAN SERAT SABUT KELAPA SEBAGAI BAHAN TAMBAH TERHADAP SUHU TINGGI
Authors: Masgode Muhammad Buttomi , Hidayat Arman , Dirgantara IArya , Fitriani Fitriani 
Published: October 2023

Kebakaran yang tejadi pada suatu bangunan seringkali menyebabkan kerusakan pada elemen strukturnya. Penelitian ini bertujuan untuk mengetahui kuat tekan beton serabut kelapa setelah terbakar dengan mutu beton rencana fc’ 20 Mpa. Penelitian ini dilakukan dengan mensimulasikan kondisi beton yang terbakar melalui media silinder ukuran 5 cm x 5 cm berjumlah 39 buah sampel. Pengujian dilakukan diumur 28 hari dengan memasukan sampel kedalam drum lalu dibakar dengan variasi suhu 200°C dan 300°C. Durasi pembakaran sampel yakni 30 menit, 60 menit, dan 90 menit. Sampel yang mencapai suhu yang ditentukan lalu didinginkan dengan cara disiram dan tanpa disiram. Hasil uji kuat tekan untuk suhu 200oC dengan perlakuan disiram, durasi 30 menit 14,33 Mpa, durasi 60 menit 10 Mpa, dan durasi 90 menit 8,42 Mpa. Untuk perlakuan tanpa disiram dengan durasi 30 menit 15,65 Mpa, durasi 60 menit 13,15 Mpa, dan durasi 90 menit 11,23 Mpa. Kuat tekan pada suhu 300oC untuk perlakuan disiram, durasi 30 menit 11,08 Mpa, durasi 60 menit 8,71 Mpa, dan durasi 90 menit 5,31 mpa. Sedangkan untuk kondisi tanpa disiram dengan suhu yang sama durasi 30 menit 13,44 Mpa, durasi 60 menit 12,26 Mpa, dan durasi 90 menit 8,71 Mpa. Sebagai pembanding kuat tekan beton serat sabut kelapa tanpa pembakaran sebesar 20,39 Mpa. Dari data diatas dapat disimpulkan bahwa semakin lama terjadinya proses pembakaran, maka kekuatan beton serat sabut kelapa akan semakin berkurang dengan rata-rata lebih dari 20%. Menurut PBI 1971 Bab 4.8 Ayat 1 menyatakan syarat kekuatan beton ekivalen dengan 80% dari nilai kuat tekan yang disyaratkan.
Aforismos de Nietzsche
Authors: Leidens Francisco Rafael 
Published: October 2023

No ano de 1997 são publicados três artigos que, de maneira independente, agem para fundamentar que o exemplo de interpretação oferecido por Nietzsche em GM III não é a passagem de Zaratustra, localizada como epígrafe, mas a primeira seção da “Terceira dissertação”. Os artigos mencionados são: Wilcox (1997), Janaway (1997) e Clark (1997). No entanto, o presente texto pretende mostrar que esse exemplo de interpretação tem motivações muito aquém do estatuto e da forma aforística assumidas por Nietzsche, uma vez que faz parte de uma tentativa de divulgação quantitativa de seus textos. Com isso, a correção dos rumos realizada por Wilcox, Janaway e Clark não revelam nenhum preceito interpretativo emblemático para a forma aforística. O aforismo, assim, permanece como um empreendimento expressivo que não pode ser acessado e esgotado apenas a partir de uma exegese que converta a concisão num ensaio mais longo. A correlação entre texto e vivência, por fim, mantém-se como um desafio ao intérprete.
Adolescent Pregnancy and Education Attainment of Female Learners in Iceme Sub County, Oyam District, Northern Uganda
Authors: Alyai Joseph , Acanga Alfred , Mwesigwa David 
Published: October 2023

Purpose: This study aimed at determining the factors associated with adolescent pregnancy, motivating factors for girls to stay in school and the effects of adolescent pregnancy on education attainment and livelihoods in Iceme Sub County, Oyam District.
Methodology: The study adopted exploratory study using a qualitative phenomenological approach. Using the principle of data saturation, the study engaged thirty-five participants that included adolescent mothers, school head teachers and other education stakeholders in two selected parishes in Iceme Sub County.
Findings: Analysis of the responses about the causes of adolescent pregnancy generated five major themes, economic status, peer influence, substance use and abuse, inadequate sex education and domestic violence. Factors motivating girls to stay in school included becoming national leaders, better living condition and independence. It was revealed that the effects of adolescent pregnancy include dropping out of school, being chased away from home, developing complications during and after delivery, poverty and producing so many children.
Unique contribution to theory, practice and policy: The study suggests adoption of remedial policy measures that include; provision of income generating opportunities to families, strengthening the implementation of policy on domestic violence and violence against children, strengthen peer to peer education/ learning, policy that does not allow sale of drugs and other substance in shops that are not licensed as drug shops and regulated by the National drug authority, provision of counselling and guidance, identification of role models who can offer guidance to girls for them to have a bright future and become national leaders and affirmative action towards girls who return to school after delivery such that they are able to complete their education. This study contributes to the understanding of the plight of adolescent girls face in a post-war region situated in a less-developing nation.
Recovery Ready Workplaces: A key strategy for reducing overdoses and sustaining recovery from substance use disorder
Authors: Fields Madison , Longley Joseph , Martinez Jennifer A. , Weizman Shelly , LaBelle Regina 
Published: October 2023

In 2021, overdose deaths surpassed the 100,000 mark for the first time in the United States’ history, and alcohol-related deaths continue to surpass 140,000 each year. Regulatory and societal barriers to effective treatment and prevention of substance use disorder (SUD) persist. Innovative strategies and approaches to support long-term recovery can help reduce morbidity and mortality associated with SUD. Improving access to quality treatment and the availability of a broad range of policies and programs to support recovery and address social determinants of health, including employment supports, are key to curbing the overdose epidemic and rebuilding stronger communities.
This article outlines the role Recovery Ready Workplaces can play in reducing overdoses and helping individuals sustain recovery from SUD, as well as in strengthening communities. This article describes how congressional and state legislative action, Americans with Disabilities Act (ADA) enforcement and expansion, and other programmatic and fiscal policy changes at the state and federal levels will accelerate the adoption of Recovery Ready Workplaces as an element of a comprehensive response to SUD. The article also identifies existing state models and proposes specific federal- and state-level solutions to address some of the current limitations.
Recovery Ready Workplaces benefit employees, employers, and the nation's economy. Recovery Ready Workplaces are a supportive tool and policy strategy to help those with SUD thrive in recovery and to bolster communities and the economy as a whole.
Opioid dependence among pregnant and post-partum incarcerated individuals: A review of the literature
Authors: Sozen Serra , Krag David , Milliren Carly 
Published: October 2023

Background: Pregnant and post-partum women with opioid dependence are an extremely vulnerable population within correctional facilities. A significant number of maternal inmates, however, still lack adequate provision of medications for opioid use disorder (OUD) and are subsequently forced into withdrawal. Currently, there exist no comprehensive reviews on the scope of literature regarding the management of this population. We aimed to provide a review on the research surrounding these women.
Design: A systematic search of PubMed Central was conducted to identify studies evaluating OUD among pregnant and post-partum incarcerated women. Citations from only the last 20 years were included to ensure both relevance and scope of information.
Results: The topics that emerged from this review included medications for OUD (MOUD) administration vs detoxification practices, treatment upon incarceration and upon release, and maternal and fetal outcomes. Across all articles, current care management of this population appeared inadequate. We further compiled all author recommendations and perspectives into a framework that can inform potential improvements in care coordination.
Conclusions: This review identifies significant gaps in current management—particularly regarding administration of MOUDs—and emphasizes the need for standardization of addiction-related and perinatal healthcare. We also highlight gaps in the literature and potential areas for future research.
Legislative and regulatory barriers to pharmacies dispensing buprenorphine for OUD
Authors: Strickland Daniel M. , Baker Jordon T. 
Published: October 2023

Introduction: Buprenorphine (BUP) is increasingly recognized and utilized as a valuable medication for the treatment of opioid use disorder. This article focuses on the problem of regulatory restrictions on access to buprenorphine products without naloxone (mono-product), involving patients in one geographic area, but which may represent a more general access problem in the United States.
Design: In response to an audit by the Tennessee Board of Pharmacy, a pharmacy in northeast Tennessee designed a questionnaire to survey patient motivation for traveling long distances to fill their prescriptions for BUP, rather than buprenorphine/ naloxone (BNx, combo-product), and to document their satisfaction with treatment with the mono-product.
Results: Questionnaires were submitted by 194 patients, living in northeast Tennessee, southwest Virginia, and southeast Kentucky. Significant, intolerable, side effects were reported by all patients in the survey prescribed BNx, but because of legislative and regulatory restrictions in their respective states, they were unable to obtain BUP closer to home. Consequently, they were required to drive significant distances from their homes to fill their prescriptions, a median distance of 52 miles, and in some cases as far as 216 miles round trip. Intolerable reactions included severe headaches, nausea and vomiting, allergies, and severe dysphoria. All patients tolerated BUP and were clinically well maintained on the mono-product.
Conclusion: Severe, intolerable reactions/side effects from the naloxone component of BNx are not uncommon, but legislative and regulatory restrictions on the mono-product prohibit providers and pharmacies in some states from prescribing and dispensing BUP. The participants in this qualitative study found it necessary to travel significant distances to obtain their prescribed medication, thereby potentially limiting access to this life-saving therapy.