bluuebunny/crossref_metadata_2025_split huggingface dataset:
Empirical Evaluation of QUIC-Based Software-Defined Service Migration in Multi-access Edge Computing Over 5G Networks
Authors: Chu Tran-Tuan , Labiod Mohamed Aymen , Augustin Brice , Mathialahan Kajanan , Mellouk Abdelhamid 
Published: February 2025

Abstract
Live Service Migration in Multi-Access Edge Computing (MEC) environments is essential to ensure seamless service continuity for users in dynamic network scenarios. While advances such as QUIC-based connection migration and CRIU-based container migration have improved reliability, they remain dependent on maintaining active connections with the source server, which is impractical in conditions of high mobility, unstable links, or server outages. Additionally, existing solutions lack a centralized mechanism to optimally manage migration paths. This study introduces the Software-Defined Service Migration (SDSM) paradigm, leveraging a centralized SDN controller, the QUIC protocol, and MEC technologies to enhance service migration. Our approach overcomes the limitations of traditional methods by preemptively coordinating container and connection migrations. Empirical evaluations on a 5G-based testbed and emulated environments demonstrate significant reductions in migration times and improved recovery in mobile scenarios. These results establish SDSM as a robust solution for next-generation network applications, ensuring consistent and adaptive service quality.
Iron Levels in Bronchoalveolar Lavage Fluid of Hematological Patients with Suspected Invasive Pulmonary Aspergillosis and their Association with 12-week Mortality: A Retrospective Cohort Study
Authors: Lamberink H. , Heijmans J. , Wagemakers A. , van Dijk K. 
Published: February 2025

Abstract

Objectives
Accuracy of diagnostic tests for invasive pulmonary aspergillosis (IPA) using bronchoalveolar lavage fluid (BALF) remains suboptimal. Elevated tissue iron in lung transplant and murine models is linked to invasive Aspergillus growth. This study examines the correlation between BALF iron levels, IPA, and 12-week mortality.

Methods
We conducted a retrospective cohort study at a tertiary care center, including 100 BALF samples from patients with hematological malignancies and suspected IPA between 2014 and 2019. Data regarding iron concentrations, mycological tests, and 12-week mortality were analyzed.

Results
Higher iron levels correlated with a greater likelihood of IPA based on EORTC/MSGERC 2020 definitions (p = 0.038). The ROC area was 0.648 (95% CI 0.531-0.764), with an optimal cut-off of 0.75 µmol/L to distinguish cases (27 probable and 0 proven IPA) from controls (56 possible and 17 no IPA), with sensitivity 76.9% and specificity 47.3%. Iron levels were positively correlated with higher fungal loads (galactomannan: Spearman’s ρ 0.323, p = 0.001; Aspergillus PCR Ct-values: ρ − 0.602, p = 0.002). A trend toward higher 12-week mortality was observed in patients with iron concentrations ≥ 0.90 µmol/L compared to lower levels (p = 0.086).

Conclusions
BALF iron concentrations were highest in those with probable IPA, followed by possible IPA and lowest in patients without IPA, with higher iron levels also correlating with fungal loads and potentially with 12-week mortality. However, given the various potential confounding factors, further prospective studies are essential to establish causality. These findings warrant additional investigation into BALF iron as a potential marker for 12-week survival, but validation is necessary before considering it as a supplementary marker in the current EORTC/MSGERC 2020 classification for probable or possible IPA.
Reappraising prediction of surgical complexity of non-functioning pituitary adenomas after transsphenoidal surgery: the modified TRANSSPHER grade
Authors: Fiore Giorgio , Bertani Giulio A. , Baldeweg Stephanie E. , Borg Anouk , Conte Giorgio , Dorward Neil , Ferrante Emanuele , Hussein Ziad , Miserocchi Anna , Miszkiel Katherine , Mantovani Giovanna , Locatelli Marco , Marcus Hani J. 
Published: February 2025

Abstract

Purpose
Prognostication of surgical complexity is crucial for optimizing decision-making and patient counseling in pituitary surgery. This study aimed to develop a clinical score to predict gross-total resection (GTR) in non-functioning pituitary adenomas (NFPAs) using externally validated machine-learning (ML) models.

Methods
Clinical and radiological data were collected from two tertiary medical centers. Patients had pre- and postoperative structural T1-weighted MRI with gadolinium and T2-weighted preoperative scans. Three ML classifiers were trained on the National Hospital for Neurology and Neurosurgery dataset and tested on the Foundation IRCCS Ca’ Granda Polyclinic of Milan dataset. Feature importance analyses and hierarchical-tree inspection identified predictors of surgical complexity, which were used to create the grading score. The prognostic performance of the proposed score was compared to that of the state-of-the art TRANSSPHER grade in the external dataset. Surgical morbidity was also analyzed.

Results
All ML models accurately predicted GTR, with the random forest classifier achieving the best performance (weighted-F1 score of 0.87; CIs: 0.71, 0.97). Key predictors—Knosp grade, tumor maximum diameter, consistency, and supra-sellar nodular extension—were included in the modified (m)-TRANSSPHER grade. The ROC analysis showed superior performance of the m-TRANSSPHER grade over the TRANSSPHER grade for predicting GTR in NFPAs (AUC 0.85 vs. 0.79).

Conclusions
This international multi-center study used validated ML algorithms to refine predictors of surgical complexity in NFPAs, yielding the m-TRANSSPHER grade, which demonstrated enhanced prognostic accuracy for surgical complexity prediction compared to existing scales.
Delineating the dyadic coping process in HIV serodiscordant male couples: a dyadic daily diary study using the common fate model
Authors: Hou Jianhua , Fu Rong , Jiang Taiyi , Yu Nancy Xiaonan 
Published: February 2025

Abstract

Purpose
Although HIV is likely to be a couple-based issue among serodiscordant male couples due to cross-partner transmission, little is known about how they cope with HIV as a team. This study aimed to examine the dyadic coping process among serodiscordant couples.

Methods
A dyadic daily diary study was used to answer our research questions. One hundred and forty-one Chinese HIV serodiscordant male couples completed measures of we-disease appraisal, common dyadic coping, quality of life, and relationship satisfaction for 14 consecutive days and ART adherence, attitudes toward PrEP, quality of life, and relationship satisfaction at a 2-month post-diary assessment. Computations were based on the common fate mediation model, using multilevel structural equation modeling.

Results
Regarding direct effect, we-disease appraisal was associated with both partners’ quality of life at the between-person level, post-diary quality of life, attitudes toward to PrEP, relationship satisfaction at both levels as well as post-diary relationship satisfaction. Common dyadic coping mediated the association between we-disease appraisal and both partners’ quality of life as well as relationship satisfaction at the within-person level. However, no mediating effects were observed at the between-person level.

Conclusions
Our findings highlighted the importance of the daily dyadic coping process among HIV serodiscordant couples. Future interventions should direct resources toward fostering a shared disease appraisal and training couples in common dyadic coping strategies for their daily lives.
The relationship between robotisation and work characteristics: a systematic literature review
Authors: Jonczyk Nina , Schweizer Theresa , González-Romá Vicente , Peiró José M. 
Published: February 2025

Abstract
Although the prevalence of robots in the workplace is growing at a considerable speed, findings on their relationship with employees’ work experiences remain scarce. This poses a challenge for managers attempting to implement robots, as the few existing studies often report contradictory findings. This systematic literature review aims to solve this issue by identifying relationship tendencies between robotisation and work characteristics and the potential moderator variables in this relationship, creating a basis for future research. Findings reflect the important role of robotisation as an antecedent to the extended Work Design Model (Humphrey et al. 2007). They reveal mixed tendencies when it comes to the relationship between robotisation and both task and contextual characteristics, with a positive tendency for knowledge characteristics and a negative tendency for social characteristics being most likely. Potential moderator variables include implementation strategy, type of job, and type of robot. We conclude the review with managerial and theoretical recommendations and outline opportunities for future research.
Digital technologies and circularity: trade-offs in the development of life cycle assessment
Authors: Toniolo Sara , Pierli Giada , Bravi Laura , Liberatore Lolita , Murmura Federica 
Published: February 2025

Abstract

Purpose
This research aims to develop a critical understanding of the employment of digital technologies (DTs) for LCA studies, outlining both the opportunities and challenges associated with circular strategies. Two research questions are thus addressed: (1) What circular loops and aspects are addressed when digital technologies are integrated in the development of a Life Cycle Inventory? (2) Which trade-offs are revealed in the integration of digital technologies in Life Cycle Inventory development addressing circularity along a life cycle?

Methods
This study is based on the problematisation approach, which critically examines existing assumptions in the LCA literature, structured into six principles: defining a domain of investigation, articulating and evaluating assumptions, developing alternative perspectives, involving the audience through qualitative interviews, and assessing the alternative assumptions. A systematic literature review (SLR) and semi-structured interviews with experts were conducted to explore these issues and suggest future research directions.

Results and discussion
It emerges that the DTs are mainly integrated in the Life Cycle Inventory phase capturing closing and narrowing loops, whereas a limited number of cases investigate slowing loops with different aspects investigated. However, even if DTs can facilitate and improve the trustworthiness of the inventory, they can also lead to an increase in complexity because more competencies are needed, it is more difficult to control data collection and elaboration, and more social interactions along the supply chain are needed. At the same time, DTs can reduce flexibility because further improvements are blocked, interfaces can be rigid to connect, and technical and normative updates can be more difficult to implement.

Conclusions
DTs improve the development of the Life Cycle Inventory phase, particularly in the context of the circular economy. However, they also introduce new complexities and challenges. The use of blockchain, digital twins, and IoT sensors, for instance, has significantly improved data transparency and traceability, which are critical for circular economy practices, but complexity and training requirements can limit their benefits, so careful consideration must be given to their implementation to maximise benefits and minimise drawbacks.
Time-Lapse Imaging of Bismuth Precipitation and Coarsening on the Surface of Sn-Ag-Cu-Bi Solder Joints After Thermal Cycling
Authors: Hsieh Chen-Lin , Coyle Richard J. , Gourlay Christopher M. 
Published: February 2025

Abstract
Adding bismuth to Sn-Ag-Cu solder compositions can significantly improve reliability in thermal cycling, but there are uncertainties in how bismuth precipitates and coarsens in Sn-Ag-Cu-Bi solders containing > 3 wt.% Bi. Here we apply time-lapse imaging in a scanning electron microscope to study bismuth precipitation and coarsening at room temperature on the polished surface of Sn-2.25-0.5Ag-6Bi ball grid array solder joints after thermal cycling. It is shown that (Bi) precipitates on the surface within 2 h after polishing and then coarsens by a combination of Ostwald ripening, coalescence ripening, and competition between two orientation relationships. Time-lapse imaging revealed that coalescence causes an increase in the local bismuth particle size and the formation of anomalously large (Bi) particles. The accumulation of bismuth on the polished surface increases far beyond the equilibrium volume fraction for this alloy. The bismuth particle size distributions are significantly wider than expected from Lifshitz–Slyozov–Wagner (LSW) theory, that assumes only Ostwald ripening, which is shown to be because coalescence creates anomalously large particles. This study shows the important role of bismuth precipitate coalescence within the coarsening mechanism in Sn-2.25-0.5Ag-6Bi solder joints.
Harnessing memetic algorithms: a practical guide
Authors: Cotta Carlos 
Published: February 2025

Abstract
The aim of this work is to provide a didactic approximation to memetic algorithms (MAs) and how to apply these techniques to an optimization problem. MAs are based on the synergistic combination of ideas from population-based metaheuristics and trajectory-based search/optimization techniques. Most commonly, MAs feature a population-based algorithm as the underlying search engine, endowing it with problem-specific components for exploring the search space, and in particular with local-search mechanisms. In this work, we describe the design of the different elements of the MA to fit the problem under consideration, and go on to perform a detailed case study on a constrained combinatorial optimization problem related to aircraft landing scheduling. An outline of some advanced topics and research directions is also provided.
Five ways to recover the symbol of a non-binary localization operator
Authors: Halvdansson Simon 
Published: February 2025

Abstract
Five constructive methods for recovering the symbol of a time-frequency localization operator with non-binary symbol are presented, two based on earlier work and three novel methods. For the two derivative methods which have previously been applied to binary symbols, we propose a changed symbol estimator and provide additional estimates that show how we can recover non-binary symbols. The three novel methods each have their own advantages and are all applicable to non-binary symbols. Two of them rely on prescribing the input of the localization operator and examining the output, allowing for targeting of the part of the symbol one wishes to recover while the last one relies on spectral information about the operator. All five methods are also implemented numerically and evaluated with the code available.
Next generation sequencing: a possible answer to sudden unexplained deaths in a young South African cohort?
Authors: van Deventer Barbara Stroh , du Toit-Prinsloo Lorraine , van Niekerk Chantal 
Published: February 2025

Abstract
Sudden cardiac death (SCD) is a major public health concern. In sub-Saharan Africa (SSA), including South Africa, there is a lack of reliable statistics on the incidence of SCD, even though there has been a fourfold increase in noncommunicable diseases (NCD), particularly cardiovascular diseases (CVD). Sudden cardiac death contributes to an estimated 50% of all cardiovascular deaths, which highlights South Africa’s need for research into better detection, treatment and prevention. This study aimed to identify an inherited cardiac arrhythmogenic disorder, linked to variants in cardiomyopathy- and arrhythmia-related genes, as a potential contributing factor to sudden cardiac deaths. DNA was extracted from blood samples collected at autopsy of 51 sudden unexpected death (SUD) cases, and subjected to next-generation sequencing (NGS) of 49 genes linked to inherited cardiac arrhythmogenic disorders. Variants were annotated and interpretated for clinical significance using the Galaxy bioinformatic platform. In total, 175 different missense variants were identified in the study population (n = 51). Of these, 92.5% (162/175) were known, documented variants, and the remaining 7.4% (13/175) were considered novel. Of the known variants, 78.4% (127/162) were of benign/likely benign significance, 20.4% (33/162) were variants of unknown significance (VUS), and 1.2% (2/162) was pathogenic. The 13 novel variants were analysed using online prediction software, with 92.3% (12/13) predicted to be likely benign and 7.7% (1/13) grouped into the VUS category. Post-mortem genetic testing provided evidence of a genetic arrhythmic/cardiac conduction disorder as the probable pathogenic basis for approximately 4% (2/51) of sudden unexpected death (SUD) cases.
Assessing pricing and affordability of HBV treatment in Asia–Pacific region: a barrier to elimination
Authors: Chen Jing , Jia Jidong , Zhuang Hui , Zhang Wenhong , Yang Jin Mo , Tanwandee Tawesak , Payawal Diana , Hamid Saeed , Sarin Shiv Kumar , Omata Masao , Wang Guiqiang , Lau George ,   Apasl Viral Elimination Task Force
Published: February 2025

Abstract

Background
The Asia–Pacific (AP) region carries a substantial burden of HBV. Affordable HBV treatment is crucial to attain WHO’s elimination goal. This study assesses the pricing and affordability of HBV treatment in AP.

Methods
A survey conducted among APASL members from 2 Aug to 30 Oct, 2023, gathered data on antiviral HBV drugs, treatment costs covering stages of chronic hepatitis B (CHB), compensated cirrhosis (CC), hepatocellular carcinoma (HCC), liver transplant, and monitoring expenses. Drug costs for TDF and ETV were compared to international reference price (TDF: $30, ETV: $36 per person per year), generating a median price ratio (MPR) where MPR < 1 indicated an acceptable local price. Affordability was evaluated by comparing yearly CHB treatment cost to yearly minimum wage in each country/area, all converted to 2023 US$.

Results
ETV costs ranged from $42 per person per year in Pakistan to $2640 in Malaysia, while TDF costs varied from $12 in mainland China to $2446 in Hong Kong. Almost all MPR exceeded 1. Affordability of HBV treatment varied, with CHB patients in Australia paying 1.4% of minimum yearly wage to get 1 year CHB treatment, in contrast to Myanmar’s 78.6%. Affordability disparities were also evident for patients with CC, HCC, and liver-transplant needs, though monitoring costs were generally affordable.

Conclusions
Despite patent expiration and availability of low-cost generics for TDF and ETV, HBV medication costs in Asia–Pacific region remain high. CHB treatment is generally unaffordable for patients, posing a significant barrier to HBV elimination in this endemic region.
Biology’s Einstein Moment: Specifying Lineal Frames of Reference and Rejecting Absolute Biological History
Authors: Haber Matthew H. 
Published: February 2025

Abstract
We are currently in the midst of what I call biology’s Einstein moment. This is the rejection of absolute biological history, the idea that there is an invariant, privileged biological history against which other histories are measured or deviate from. Instead, biologists must specify theoretically and empirically motivated frames of lineal reference. This is already informing and advancing biological practice, theory, methods, and more, and is a significant and important feature of contemporary biology. Here I argue that it is worth identifying and naming this shift, and encouraging a deeper and broader embrace of it.
Validation of the Italian version of the intuitive exercise scale: a four-factor structure in the general population
Authors: Mancin Paolo , Ghisi Marta , Moro Tatiana , Cerea Silvia 
Published: February 2025

Abstract

Purpose
Intuitive exercise may foster healthier engagement in physical activity, leading to enhanced well-being and more intuitive eating habits. The Intuitive Exercise Scale (IEXS) was originally developed to assess this construct in English speakers. The IEXS is composed of four scales addressing distinct facets of intuitive exercise: emotional exercise, body trust, exercise rigidity, mindful exercise. The present study aimed to validate an Italian translation of the IEXS, exploring its factorial structure, invariance, internal consistency, and convergent validity.

Methods
A sample of 1140 women and men (age: M = 45.25, SD = 11.64, range 22–76 years) was recruited from the Italian general population; 61.8% were physically active. Inclusion criteria were being an Italian native speaker and being at least 18 years. The sample was randomly split in two equal halves for the Exploratory Factor Analysis (n = 570; women: 50%; physically active: 61.8%) and the Confirmatory Factor Analysis (n = 570; women: 50%; physically active: 61.8%). Multi-group confirmatory factor analyses were performed to assess invariance among women and men and physically and non-physically active individuals. McDonald’s omega was used to assess internal consistency. Pearson’s correlations were utilized to assess convergent validity.

Results
The Italian IEXS replicated a four-factor structure and showed good invariance among women and men. Invariance among physically and non-physically active individuals was only partially supported. Excellent internal consistency and adequate convergent validity were achieved.

Conclusions
The IEXS demonstrated to be a valid measure to examine intuitive exercise in the Italian population, replicating and expanding the findings of the English version.

Level of evidence Level V, Cross-sectional, Psychometric study.
Wie man denn spricht: Die beste hut / Ist, die im ain mensch selber thut! Semantisierungen der (inneren) huote
Authors: Manuwald Henrike 
Published: February 2025

Zusammenfassung
Konzepte der inneren huote finden sich in Minne- und Ehe-Diskursen wie auch im Seelenheil-Diskurs. Vor dem Hintergrund des Bedeutungsspektrums von mhd. huote und lat. custodia, wie es in Wörterbüchern erschlossen ist, wird exemplarisch an Predigten Bernhards von Clairvaux und der Minnerede Minneburg sprach- und diskursübergreifend gezeigt, wie unter Rückgriff auf das Bildfeld einer zu verteidigenden Burg die innere huote mithilfe äußerer Instanzen umschrieben wird. In den ausgewählten Texten bringen Darstellungsmittel wie Metapher, Personifikation und Allegorie zum Ausdruck, dass bei der inneren huote Subjekt und Objekt zusammenfallen können. Direkte Diskursinterferenzen lassen sich dabei nicht nachweisen, vielmehr Bezüge auf bekannte Vorstellungen von huote, die sich auch in Sprichwörtern manifestiert haben. Über die jeweiligen Konkretisierungen der inneren huote werden letztlich Facetten des Selbst thematisiert.
Der Lebensweg: Historische Semantiken einer diagrammatischen Metapher
Authors: Friedrich Udo 
Published: February 2025

Zusammenfassung
Der Beitrag skizziert die diagrammatische Struktur der Lebenswegmetapher von der Antike bis zur Frühen Neuzeit. Die epochenspezifische Besetzung hängt einerseits vom Weltbild und von je eigenen Diskursregeln ab, andererseits werden diese von literarischen Strategien genutzt, kritisiert und unterminiert. Indem der Lebensweg über die Erzählung als Lebenslauf in Gang kommt, eröffnen sich im historischen Prozess unendliche Variationen.