bluuebunny/crossref_metadata_2025_split huggingface dataset:
Reduced-dose without the post-procedure infusion of bivalirudin in patients with acute coronary syndrome undergoing elective percutaneous coronary intervention
Authors: Wang Qian , Zhou Tienan , Yang Lin , Li Jingyuan , Zhang Quanyu , Wang Xiaozeng 
Published: November 2023

Abstract

Introduction: In clinical practice, the dose of bivalirudin may not be fully applicable to the Chinese population. Therefore, this study aimed to explore the efficacy and safety of a reduced dose (80% of the recommended dose) of bivalirudin without post-procedure infusion for 3-4 h in patients with acute coronary syndrome (ACS) undergoing elective percutaneous coronary intervention (PCI).
Methods: This was a single-center, retrospective study. Patients who met the inclusion criteria and no exclusion criteria were divided into reduced-dose and recommended-dose groups for analysis. Confounders were corrected using propensity score matching. The incidence of net adverse clinical events (NACE), major adverse cardiovascular events (MACE), and Bleeding Academic Research Consortium (BARC) type 2-5 bleeding events were observed 30 days postoperatively.
Results: In total, 1,584 patients (792 per group) were obtained after propensity score matching. The results after propensity score matching were as follows: The activated clotting time (ACT) after 5 min in the reduced-dose group was 349.30±47.60 s, which was statistically lower than that in the recommended-dose group, 353.41±44.89 s (P = 0.021). There was no significant difference in the proportion of ACT values of ≥250 s after 5 min between the two groups (P > 0.05). There were no significant differences in NACE, MACE, and BARC type 2-5 bleeding events between the two groups (5.1% vs. 4.5%, P = 0.638; 0.0% vs. 0.1%, P = 1.000; 0.3% vs. 0.5%, P = 0.687). There were no statistically significant differences in cumulative NACE and cumulative bleeding events between the two groups at 30 days (P = 0.633 and P = 0.715, respectively).
Conclusion: In patients with acute coronary syndrome undergoing elective PCI, 80% of the recommended dose of bivalirudin without post-procedure infusion can be used for anticoagulation without increasing the risk of thrombosis and bleeding.
Study on the mechanism of BGN in progression and metastasis of ccRCC
Authors: Xia Hanqing , He Tianzhen , Li Xueyu , Zhao Kai , Zhang Zongliang , Zhu Guanqun , Wang Zhenlin , Yang Han , Yan Xuechuan , Wang qinglei , Li Zhaofeng , Jiang Zaiqing , Wang Ke , Yin Xinbao 
Published: November 2023

Abstract
Purpose
To investigate the role of BGN in the progression and metastasis of ccRCC.
Methods
Based on multiple public databases, we investigated the expression level of BGN in ccRCC, its clinical significance, and its association with immune cells. Real-time fluorescence quantitative PCR was employed to validate BGN expression in tumor and adjacent normal tissues. BGN knockdown cells were generated through lentiviral transfection to examine the impact of BGN on ccRCC. Cell proliferation, migration, and invasion were assessed using wound healing, transwell migration, and invasion assays, respectively. Differential gene analysis, GO-KEGG analysis, and GSEA analysis were performed by RNA sequencing to elucidate the underlying signaling pathways .
Results
Our findings from database analysis and polymerase chain reaction (PCR) revealed a significant upregulation of BGN expression in kidney cancer tissues compared to normal tissues. Further analysis demonstrated a correlation between high BGN expression and ccRCC progression and immune infiltration. In vitro experiments confirmed that BGN silencing effectively inhibited cell proliferation, migration, and invasion of ccRCC. Mechanistically, these effects may be mediated through the MAPK signaling pathway .
Conclusion
BGN potentially plays a pivotal role in the progression and metastasis of ccRCC, possibly acting through the MAPK signaling pathway. Therefore, BGN holds promise as a potential therapeutic target for ccRCC.
The effects of Arbuscular Mycorrhizal Fungi and Silicon on Tomato growth in normal and arid conditions through different water regulation mechanisms
Authors: ÇELİK Yusuf , BAYDAR Alper 
Published: November 2023

Abstract
Drought has a greater effect on tomato cultivation in greenhouse conditions. Therefore, alternatives have been selected that promote more efficient use of water and fertilizer through exogenous application of Silicon (Si) and Arbuscular Mycorrhizal Fungus (AMF) inoculation. The research was established according to the randomized block trial design with three replications. Irrigation issues according to the amount of evaporation in Class A evaporation container; It was created by giving 40% (I0.40), 60% (I0.60), 80% (I0.80) and 100% (I1.00) full irrigation. Si treatments; It was created from doses of 0, 50, 100 and 150 kg.ha-1. Due to increased irrigation, the sixAMFxI combination increased fruit length by 11.5%, fruit diameter by 8.2%, fruit weight by 16.1%, fruit firmness by 7.8%, and fruit number by 7.9% compared to single applications of Si and AMF. In addition, nutritional values; It increased at 21% N, 33% P, 22% K, 14.1% Ca, 15.7% Mg, 11.9% Fe and 46% Mn. In conclusion; Si+AMF fertilizer combination can be considered as a suitable water management strategy for tomato cultivation in arid and semi-arid regions.
Design and analysis of polarization-insensitive Molybdenum-based ultra-wideband solar energy absorber with wide-incident-angle
Authors: Abouelez Ahmed Elsayed , Eldiwany Essam A. 
Published: November 2023

Abstract

We introduce an ultra-wideband absorber with a molybdenum and Al2O3 multilayer structure for solar energy harvesting. The proposed structure could maintain its structural integrity at high temperatures thanks to the refractory materials used in its construction. Under normal incidence of optical waves, absorption of more than 90% is achieved throughout a broad range of wavelengths from 300 nm to approximately 3177 nm with a bandwidth of 2877 nm which covers ultraviolet, visible, and near-infrared spectral bands. The average absorption in that band is calculated to be 96.46%. The proposed design's symmetrical characteristic makes the absorber insensitive to the polarization of the incident optical wave. Furthermore, throughout a broad range of optical wave angles of incidence for both transverse electric and transverse magnetic polarizations, the absorber supports absorptivity greater than 80%.
Consumption of Antarctic krill Euphausia superba by mackerel icefish, Champsocephalus gunnari off the South Orkney Islands: filling an information gap in the current ecosystem based management approach
Authors: Canseco Jose Antonio , Alegría Nicolas , Niklitschek Edwin 
Published: November 2023

Abstract

The Antarctic marine ecosystem is largely dominated by Euphausia superba, the most abundant krill species consumed by a large number of predators, including whales, penguins, flying birds, seals, fish and cephalopods. Current management of the krill fishery follows an ecosystem-based approach which takes into account the distribution, abundance of E. superba and its main predators plus their interactions. Mackerel icefish, Champsocephalus gunnari, was once considered the most abundant meso-pelagic fish species and a very important consumer of E. superba until its population was collapsed by overfishing in the early 90s. Currently, C. gunnari populations are slowly recovering which will increase E. superba predation. Therefore, in the present work, we analyze the distribution and density of E. superba and C. gunnari, gain some insights about the type of foraging strategy of C. gunnari and estimate its consumption on E. superba is consumed by C. gunnari under three different biomass scenarios: 7,000 (Bt), 70,000 (B50%) and 140,000 (B0) t. We put special focus on the potential area of overlapping between C. gunnari and Adélie penguin (Pygoscelis adeliae) off the South Orkney islands. Bayesian geostatistical models were used to test whether C. gunnari followed an ideal or generalized ideal free distribution. Spatially explicit consumption estimates were obtained under scenarios of 7,000 (Bt), 70,000 (B50%) and 140,000 (B0) t of C. gunnari biomass. We found that both species have a higher probability of presence and density north of the South Orkney Islands, where they present a high overlap. The probability of presence of Champsocephalus gunnari was best explained by the ideal free distribution whereas its acoustic density was best explained by an independent spatial model that lacked any relation with the distribution of E. superba. Individual consumption of E. supeba by C. gunnari was estimated to be 153.5 ± 77.9 g ind-1. Thus, current biomass (Bt) would only remove ~ 0.07% of E. superba biomass in the focus area. Under a pre-exploitation biomass level (B0), C. gunnari would remove ~ 1.4% of E. superba biomass. The present work present novel information on the relationship between a key species like E. superba and a highly specialized consumer such as C. gunnari around the South Orkney Islands and contributes to fill in an important gap regarding fish consumption of krill in the Antarctic ecosystem.
Automatic calculation for pulse wave morphology change: a rheoencephalographic study
Authors: Szabo Sandor , Bodo Michael , Bagany Mihaly , Pinter Istvan 
Published: November 2023

Abstract

Purpose
The intracranial pressure (ICP) pulse waveform morphological alteration indicates the decreasing intracranial compliance/elevation of ICP by increasing the amplitude of the second peak (P2). It is useful information at the bedside, but its invasive nature is a problem. It was demonstrated that a noninvasive method, called rheoencephalography (REG), correlates with ICP. We compared the correlation of the new program calculating automatically the P2 change to manually calculated results.
Methods
REG was measured in 19 healthy volunteers. Pulse waves were recorded with a 200 Hz sampling rate on a laptop. Measurements were made by cursor operation and with a MATLAB script developed for the automated calculation of P2 amplitudes on 10 pulse waves during control and head-down tile (HDT) positions.
Results
During the HDT position, the P2 amplitude increased. Manual reading resulted in a significant difference in the female group (P = 0.0007) and the male group (P < 0.0001). With automated analysis, the REG P2 increase was significant, and the ratios were 4/5 (80%) for females and 10/14 (71%) for males.
Conclusion
The significance difference can be interpreted as follows: the manual P2 reading was clearer from artifacts than the automated calculation, which involved all lengths of the HDT position time, while the manual reading involved only 10 artifact-free P2 values. We initiated a study in which ICP and REG are recorded together, and it will be possible to compare their correlation. Such confirmation opens the use of REG in neurocritical care monitoring, space research, and military applications.
Asthma Prevalence among United States Population: Updated Estimation from NHANES Dataset
Authors: Swed Sarya , Sawaf Bisher , Abidat Firas , Hafez Wael , Rakab Amine , Alibrahim Hidar , Nasif Mohamad Nour , Alghalyini Baraa , Zaidi Abdul Rehman Zia , Alshareef Lamees , Alqatati Fadel , Zahir Fathima Zamrath , Ahmed Ashraf I. , Alom Mulham , Sultan Anas , AlMahmoud Abdullah , Bakkour Agyad , Cherrez-Ojeda Ivan 
Published: November 2023

Abstract
Background
Asthma is a prevalent respiratory condition that poses a substantial burden on public health. Understanding its prevalence and associated risk factors is vital for informed policymaking and public health interventions. This study aims to examine asthma prevalence and identify major risk factors in the U.S. population.
Methods
Our study utilized NHANES data between 1999 and 2020. We analyzed a dataset of 64,222 participants, excluding those under 20 years old. We performed chi-square test to examine various demographic and health-related covariates.
Results
The study found that asthma affected 8.7% of the U.S. population. Gender emerged as a significant factor, with 36.0% of asthma patients being male and 64.0% female (p < 0.001). Individuals aged 60 and older having the highest asthma prevalence at 34.0%. Non-Hispanic whites had the highest prevalence at 46.4%, followed by non-hispanic blacks at 26.0%. In contrast, Mexican Americans and other hispanic individuals had lower rates, at 9.6% and 9.0%, respectively. Females were 1.76 times more likely to have asthma than males (p < 0.001). Obese individuals had a 1.74 times higher likelihood of current asthma compared to underweight individuals (p < 0.001). Notably, both Non-Hispanic Whites and Non-Hispanic Blacks showed higher odds of current asthma compared to Mexican Americans (with adjusted odds ratios of 2.084 and 2.096, respectively, p < 0.001).
Conclusion
The research findings indicate that asthma is prevalent in 8.7% of the U.S. population. Our study highlights that individuals who are female, have low income, are obese, and smoke have the highest likelihood of being affected by asthma. Therefore, public health policies should prioritize addressing these risk factors in their preventive strategies.
Nurses' Level of Awareness of Patients' Rights in hospitals
Authors: Alraimi Ammar , Shelke Prof. Abhijeet 
Published: November 2023

Abstract
This research evaluated the awareness levels of nursing staff concerning patients' rights in Yemeni hospitals. Using a descriptive cross-sectional approach, the research employed a simple random sampling technique to enlist 384 nursing personnel across four hospitals situated in Sana'a, Yemen. A questionnaire based on the Yemeni Patients' Rights Charter and relevant literature on patients' rights was employed to gather data. The findings revealed a high overall awareness level among nursing staff regarding patients' rights, with a mean of 84.4%. The special right dimension exhibited the highest awareness level (88%), while the knowledge dimension recorded the lowest level (79%). The investigation identified no statistically significant variations in awareness levels attributable to demographic factors such as gender, marital status, age, occupation, experience, and educational qualifications. However, differences were observed in awareness levels based on the hospital type, as private hospitals displayed higher awareness than government hospitals. The results underscore the necessity for tailored educational initiatives targeting nursing staff to address identified knowledge gaps, particularly in government hospitals. Additionally, the study emphasizes the importance of safeguarding patients' property against theft, damage, and loss by educating nursing staff on patients' right to know the identity and qualifications of healthcare providers – a crucial aspect of patients' rights that nursing staff must be cognizant of to ensure quality care provision.
Moving Beyond Frameworks: Stakeholders' Perceptions of Risk Assessment in National Electronic Identity System
Authors: Edu Jide , Hooper Mark , Maple Carsten , Crowcroft Jon 
Published: November 2023

Abstract

National Electronic Identity System (NeIDS) has become crucial for verifying the identities of citizens and granting access to digital services in public and private domains. However, implementing NeIDS has raised concerns about security, privacy, and exclusion. Furthermore, conducting a comprehensive risk assessment for NeIDS is challenging, as it is interconnected, multifaceted, and relational. To understand the challenges faced by stakeholders during the risk assessment process and explore the reality of conducting a risk assessment for NeIDS, we conducted a qualitative study based on semi-structured interviews with 17 stakeholders. Following a thematic analysis of the interview transcript data, we found that i) stakeholders are concerned with assessment bias, political influences, lack of transparency, inclusion issues, and inadequate communication about the assessment process, and ii) there are key issues around framework considerations, implementation, regulation, and funding of risk assessments. Finally, we offer recommendations to ensure a fair, transparent, and inclusive assessment process.
The Role of circRNA-miRNA-mRNA Regulatory Network and its
Potential Biomarker Function in Colorectal Cancer
Authors: Fu Xutang , Chen Pengpeng , Wang Hao 
Published: November 2023

Background:
Revealing the process and mechanism of colorectal cancer will facilitate
the discovery of new biomarkers and contribute to the development of targeted drugs.

Objective:
This study aimed to explore the potentially functional circRNA-miRNA-mRNA network
in colorectal cancer (CRC), and further explore its mechanism.

Methods:
Bioinformatics analysis was used to identify the differentially expressed circRNAs and
mRNAs. Gene set enrichment analysis and KEGG pathways analysis were used to screen out the
differentially expressed genes and observe crucial pathways that might have a strong association
with CRC. Then, a network targeting circRNA, miRNA, and mRNA has been built by using the
Cytoscape software. In addition, the expression of circRNA_0001573, miR-382-5p, and FZD3 was
detected by qRT-PCR in CRC tissues and cells (SW480, HCT116, and HT29).

Results:
Abnormal expressions of circRNAs and mRNAs were obtained by bioinformatics analysis
and visualized by Volcano plot and Heatmap. A series of highly correlated pathways were enriched
by KEGG analysis. The interaction network of circRNA_0001573/miR-382-5p/FZD3 axis was
predicted. The expressions of circRNA_0001573 and FZD3 were highly upregulated and the miR-
382-5p expression level was decreased in CRC tissues and cell lines (SW480, HCT116, and HT29).

Conclusion:
Our study suggests that circRNA_0001573 and circRNA_0001573/miR-382-5p/FZD3
regulatory networks might provide a potential diagnosis for colorectal cancer.
Reconciling the Gap between Medications and their Potential Leads: The Role of Marine Metabolites in the Discovery of New Anticancer Drugs: A Comprehensive Review
Authors: Thaman Janvee , Saxena Pal Rashmi , Chaitanya Motamarri Venkata Naga Lalitha , Yanadaiah Palakurthi , Thangavelu Prabha , Sharma Sarika , Amoateng Patrick , Arora Smriti , Sivasankaran Ponnusankar , Pandey Pratibha , Mazumder Avijit 
Published: November 2023

Abstract:One-third of people will be diagnosed with cancer at some point in their lives, making it the second leading cause of death globally each year after cardiovascular disease. The complex anticancer molecular mechanisms have been understood clearly with the advent of improved genomic, proteomic, and bioinformatics. Our understanding of the complex interplay between numerous genes and regulatory genetic components within cells explaining how this might lead to malignant phenotypes has greatly expanded. It was discovered that epigenetic resistance and a lack of multitargeting drugs were highlighted as major barriers to cancer treatment, spurring the search for innovative anticancer treatments. It was discovered that epigenetic resistance and a lack of multitargeting drugs were highlighted as major barriers to cancer treatment, spurring the search for innovative anticancer treatments. Many popular anticancer drugs, including irinotecan, vincristine, etoposide, and paclitaxel, have botanical origins. Actinomycin D and mitomycin C come from bacteria, while bleomycin and curacin come from marine creatures. However, there is a lack of research evaluating the potential of algae-based anticancer treatments, especially in terms of their molecular mechanisms. Despite increasing interest in the former, and the promise of the compounds to treat tumours that have been resistant to existing treatment, pharmaceutical development of these compounds has lagged. Thus, the current review focuses on the key algal sources that have been exploited as anticancer therapeutic leads, including their biological origins, phytochemistry, and the challenges involved in converting such leads into effective anticancer drugs.
Kenaf Seed Cysteine Protease (KSCP) Inhibits the Intrinsic Pathway of
the Blood Coagulation Cascade and Platelet Aggregation
Authors: Hanumegowda Sujatha M. , Srinivasa Chandramma , Shivaiah Ashwini , Venkatappa Manjula M. , Shankar Rohith L. , Lakshmaiah Ramesh K. , Gonchigar Sathisha J. , Sannaningaiah Devaraja 
Published: November 2023

Background:
Thrombosis is the key event that obstructs the flow of blood throughout
the circulatory system, leading to stroke, myocardial infarction and severe cardiovascular complications.
Currently, available antithrombotic drugs trigger several life-threatening side effects.

Introduction:
Antithrombotic agents from natural sources devoid of adverse effects are grabbing
high attention. In our previous study, we reported the antioxidant, anticoagulant and antiplatelet
properties of kenaf seed protein extract. Therefore, in the current study, purification and characterization
of cysteine protease from kenaf seed protein extract responsible for potential antithrombotic
activity was undertaken.

Methods:
Purification of KSCP (Kenaf Seed Cysteine Protease) was carried out using gel permeation
and ion exchange column chromatography. The purity of the enzyme was evaluated by SDS
PAGE (Sodium Dodecyl-Sulfate Polyacrylamide Gel Electrophoresis). RP-HPLC (Reverse Phase
High-Performance Liquid Chromatography), MALDI-TOF (Matrix-Assisted Laser Desorption
Ionization Time-Of-Flight) and CD (Circular Dichroism techniques) were employed for its characterization.
Proteolytic, fibrinolytic and kinetic study was done using spectroscopy. Plasma recalcification
time, Prothrombin Time (PT), Thrombin clotting time (TCT), Activated Partial Thromboplastin
Time (APTT), bleeding time and platelet aggregation studies were carried out for antithrombotic
activity of KSCP.

Result:
A single sharp band of KSCP was observed under both reduced and non-reduced conditions,
having a molecular mass of 24.1667kDa. KSCP was found to contain 30.3 % helix turns
and 69.7 % random coils without a beta-pleated sheet. KSCP digested casein and fibrin, and its activity
was inhibited by iodoacetic acid (IAA). KSCP was optimally active at pH 6.0 at the temperature
of 40°C. KSCP exhibited anticoagulant properties by interfering in the intrinsic pathway of
the blood coagulation cascade. Furthermore, KSCP dissolved both whole blood and plasma clots
and platelet aggregation.

Conclusion:
KSCP purified from kenaf seed extract showed antithrombotic potential. Hence, it
could be a better candidate for the management of thrombotic complications.
Naringenin-induced Oral Cancer Cell Apoptosis Via ROS-mediated Bid
and Bcl-xl Signaling Pathway
Authors: Du YuYe , Lai Jia , Su Jingyao , Li Jiali , Li Chuqing , Zhu Bing , Li Yinghua 
Published: November 2023

Background:
Oral cancer is a malignant tumor with a high impact and poor prognosis.
Naringenin, a flavonoid found in citrus fruits and its anti-inflammatory and antioxidant properties
offer potential therapeutic benefits. However, limited studies have been conducted on the impact
of naringenin on human tongue carcinoma CAL-27 cells. This study aims to elucidate the correlation
between naringenin and tongue cancer, thereby identifying a potential therapeutic candidate
for drug intervention against tongue cancer.

Methods:
The effect of naringenin on the apoptosis of CAL-27 cells and its mechanism were
studied by cell counting kit-8, mitochondrial membrane potential assay with JC-1, Annexin V--
FITC apoptosis detection, cell cycle, and apoptosis analysis, Reactive Oxygen Species assay and
Western blot.

Results:
The results showed that naringenin significantly induced apoptosis in CAL-27 cells in a
dose-dependent manner. Mechanistically, naringenin-induced apoptosis was mediated through the
upregulation of Bid and downregulation of Bcl-xl, which led to increased generation of ROS.

Conclusion:
The findings suggested that naringenin may represent a promising candidate for the
treatment of oral cancer by inducing apoptotic cell death via modulation of the Bid and Bcl-xl signaling
pathways.