bluuebunny/crossref_metadata_2025_split huggingface dataset:
Evaluating Surgeon-influenced Factors for Total Knee Arthroplasty Value-based Reimbursement
Authors: Sutton Ryan , Lizcano Juan , Krueger Chad A. , Courtney P. Maxwell , Purtill James J. , Austin Matthew S. 
Published: January 2025

Introduction:
Clinical outcome measures used under value-based reimbursement models require risk stratification of patient demographics and medical history. Only certain perioperative patient factors may be influenced by the surgeon. The study evaluated surgeon-influenced modifiable factors associated with achieving literature-defined KOOS score thresholds to serve as the foundation of the newly established alternative payment models for total knee arthroplasties (TKA).

Methods:
We retrospectively reviewed a consecutive cohort of 4,324 patients undergoing TKA. Surgeon-influenced modifiable risk factors included thromboprophylaxis with aspirin, tourniquet use, tranexamic acid (TXA), body mass index, smoking, alcohol or illicit drug use, surgical time, length of stay (LOS), and bilateral TKA. Outcomes included complications, 90-day readmissions, discharge disposition, knee injury and osteoarthritis outcome score (KOOS) minimal clinically important difference (MCID), KOOS patient acceptable symptom state (PASS), and short form-12 (SF-12) MCID achievement. A bivariate analysis and regression were built to determine the likelihood of primary outcomes based on modifiable factors.

Results:
Bilateral TKA was associated with a higher odds ratio (OR) for home discharge (OR = 5.40, P < 0.001), KOOS MCID (OR = 2.60, P < 0.001), PASS (OR = 2.4, P ≤ 0.001), and SF-12 PCS MCID achievement (OR = 3.21, P < 0.001). Similarly, LOS was inversely associated with KOOS MCID (OR = 0.88, P = 0.002) and PASS (OR = 0.81, P < 0.001) but directly associated with home discharge (OR = 2.5, P ≤ 0.001) in-hospital complications (OR = 1.50, P < 0.001) and 90-day readmissions (OR = 1.23, P = 0.005). The KOOS MCID and PASS achievement was positively influenced by TXA (OR = 1.33, P = 0.008; OR = 1.29, P = 0.020) use and negatively influenced by aspirin use (OR = 0.68, P = 0.013; OR = 0.73, P = 0.040). In-hospital opioid use was an independent risk factor for not achieving SF-12 MCS MCID (OR = 0.56, P = 0.006).

Conclusion:
In this study, modifiable perioperative variables, such as TXA, aspirin use, opioid use, LOS, and bilateral TKA, were found to markedly increase quality metrics threshold achievement and should be considered as risk variables in the current value-based care models. Future studies should investigate the effect of modifiable risk factors on quality metrics to build new risk adjustment tools that incentivize patient perioperative optimization.
ANALISIS PERHITUNGAN HARGA POKOK PRODUKSI UNTUK MENENTUKAN HARGA JUAL MENGGUNAKAN METODE FULL COSTING PADA UMKM TAHU BANDUNG BAROKAH
Authors: Eva Khadijah  , Siti Aisyah  
Published: January 2025

Perhitungan Harga pokok produksi dengan menggunakan metode Full Costing sangatlah dianjurkan bagi usaha manufaktur karena perhitungannya memasukkan semua komponen- komponen biaya produksi, selain lebih rinci dalam perhitungannya metode Full Costing juga diterima secara umum dan dapat menjadi alat ukur perhitungan bagi UMKM. Tujuan dalam penelitian ini untuk mengetahui perhitungan harga pokok produksi Tahu Bandung Barokah dengan metode Full Costing dalam menentukan harga jual. Full Costing merupakan metode penentuan biaya produk yang membebankan seluruh biaya yang berperilaku variabel maupun tetap.Penelitian ini termasuk penelitian deskriptif kuantitatif. Data dikumpulkan melalui wawancara dan dokumentasi utuk mengetahui laporan biaya produksi, dan informasi mengenai harga jual tahu selama bulan Oktober 2024. Metode penelitian yang digunakan untuk mengetahui harga pokok produksi dan harga jual adalah metode Full Costing dengan presentasi Cost Plus Pricing. Hasil penelitian terjadi perbedaan harga pokok produksi perusahaan dengan metode Full Costing sebesar Rp. 175.556.167. ketidaksesuain ini disebabkan karna biaya Overhead tetap yang dibebankan dengan metode Full Costing sebesar Rp4.202.167. Harga jual tahu menurut perusahaan sebesar Rp. 714,6/pcs dan menurut metode Full Costing sebesar Rp.730,2/pcs dengan jumlah produksi sebanyak 270.000 pcs.
Defluoridation of Contaminated Mine Water by Adsorption on the Fly Ash in the Static and Dynamic Reactor: A Case Study in Morocco
Authors: Ahmed Moufti , Mohamed Taoufik , Afaf Amri , Jamal Mabrouki , Mohammed Mountadar , Hocine Garmes 
Published: January 2025

In this study, we are interested in the elimination of fluoride ions in a batch and dynamic reactor by adsorption on fly ash from the Jorf-Lasfar thermal power plant in El Jadida, Morocco. Indeed, the results obtained showed that the fly ash made it possible to have treated water meeting international standards for fluorides and certain metals such as Pb and Fe; they will undergo a combined treatment. The elimination efficiency increases with the mass of the adsorbent and the stirring speed, with the pH values in a basic medium (7 < pH < 9.5), and this is for a treatment at room temperature. Additionally, it was concluded that fly ash can be used for fluoride removal in waters with high fluoride concentrations. The results obtained in a dynamic reactor have shown that a fluoride elimination percentage of 97% can be reached under the optimal conditions of our experiment. According to its encouraging results by the simplicity proper to the work, the reasonable cost of the works and the equipment and the good efficiency of elimination, it can be foreseen that the fly ash can be used as a filterable adsorbent in the field of water defluoridation.
Exploring the Bisphenol A Paradigm: Historical Evolution, Environmental Presence, Pharmacokinetics, and Societal Impact
Authors: Moreno-Gómez-Toledano Rafael 
Published: January 2025

Bisphenol A (BPA) is a phenolic compound molecule found in the daily lives of people worldwide. The significance of BPA has grown considerably in recent decades, despite its known properties as an endocrine disruptor for over 80 years. This chapter will delve into the paradigm of BPA, examining its history, its presence in the environment, its pharmacokinetics, and how it has impacted contemporary society. The growing body of evidence has led to a significant societal shift, prompting the enactment of new laws that restrict or ban the use of BPA. As a result, the industry has started to employ structurally analogous alternatives whose estrogenic properties may be comparable to those of BPA itself. Consequently, it is imperative to prioritize the investigation of these novel molecules while governments implement the precautionary principle. This strategic approach is essential for shielding the population from potential new risks associated with these emerging compounds. Timely institutional action and the minimization of exposure to emerging endocrine disruptors can effectively prevent or mitigate numerous health impacts on the population, particularly among younger generations.
Analisis Dampak Aktivitas Industri Minyak Dan Gas Terhadap Sektor Ekonomi Di Kabupaten Seram Bagian Timur
Authors: Asmiani Nur , Rahareng Sutriani , Thamsi Alam Budiman , Aswadi Muhammad 
Published: January 2025

PT Kalrez Petroleum Seram Ltd is a company engaged in the oil and gas mining sector. The company started operations in 2001 and is part of South Sea Petroleum Holdings Ltd, based in Hong Kong. This study aims to analyze the base sectors that can support economic growth and examine the potential of the mining and quarrying sector in supporting economic development in the region. The data used in this study is secondary data obtained from various related agencies, one of which is the Central Statistics Agency (BPS). The data analyzed includes the Gross Regional Domestic Product (GDP) of Eastern Seram Regency and Maluku Province based on constant prices by business field in the 2011-2020 period. This study uses Location Quotient (LQ) and shift-share analysis methods to identify the base sector and analyze the dynamics of economic growth. The results of the analysis show that the base sectors in this area include the fisheries, forestry, and agriculture sectors with an LQ value of 1.06; mining and quarrying sector with an LQ value of 11.37; real estate services with an LQ value of 1.13; and health services and social activities with an LQ value of 1.07. However, the growth of the value of GDP in the mining sector during the 2011-2020 period experienced a significant decrease, namely -6,323.94 million rupiah. Other growth indicators, namely the Proportional Growth Contribution (KPP) of -0.22 and the Regional Growth Contribution (KPPW) of -0.14, also show that the mining and quarrying sector is relatively slow in growth, although it remains competitive at the regional level. The decline in the value of KPP and KPPW with a negative sign (-) in the mining and quarrying sector confirms that this sector is experiencing suboptimal growth. Although its competitiveness is relatively still there, this persistent decline indicates the need for more attention to improving efficiency and innovation within the sector. This is important so that the mining and quarrying sector can contribute more to improving the regional economy in a sustainable manner. To support the development of this sector, strategic policies, investment in technology, and synergy between the government and industry players are needed to overcome existing challenges
Evaluation of Serum Zonulin Level and Intestinal Permeability in Patients with Chronic Spontaneous Urticaria and the Relationship Between Serum Zonulin Level and Disease Severity
Authors: Ünal Simge , Kartal Selda Pelin , Ozsoy Ahmet , Aydın Fevzi Nuri 
Published: January 2025

Introduction: An emerging hypothesis suggests a potential link between enhanced intestinal permeability and the advancement of chronic spontaneous urticaria (CSU). Objective: This study aimed to investigate the role of intestinal permeability in the etiopathogenesis of CSU by measuring serum zonulin levels, a marker of intestinal permeability, in both CSU patients and control subjects. Additionally, the study sought to explore the correlation between the severity of the illness and zonulin levels. Methods: The study involved 61 patients with CSU and 59 healthy control individuals. For the CSU patients, comprehensive data was collected, encompassing various aspects: age at onset of the condition, duration of the most recent attack, presence of any comorbid conditions, dosage of antihistamines being used, the urticaria activity score, as well as detailed personal and family medical histories. Additionally, demographic information for these patients was also meticulously documented. Result: The study revealed a statistically significant difference in zonulin levels between the CSU patient group and the control group, with a p-value of 0.000 indicating a highly significant disparity. Furthermore, among the CSU patients, those who were presented with angioedema exhibited considerably higher zonulin levels compared to those without angioedema. This variation in zonulin levels based on the presence of angioedema was also statistically significant, with a p-value of 0.023. Conclusion: The observed results suggest that increased intestinal permeability, as indicated by elevated zonulin levels, may play a crucial role in the pathophysiology of both CSU and angioedema. This association highlights the potential significance of intestinal permeability in the development and manifestation of these conditions.
Trichoscopic Features of Lichen Planopilaris versus Frontal Fibrosing Alopecia: A Systematic Review
Authors: Gowda Shreya K. , Errichetti Enzo , Behera Biswanath , Thakur Vishal 
Published: January 2025

Introduction: Lichen planopilaris (LPP) and frontal fibrosing alopecia (FFA) are primary scarring alopecias that few authors consider the same entity, and some consider them different. Objective: We describe and summarize the trichoscopy features of both conditions. Methods: We performed extensive literature search using the PubMed and Google Scholar databases. The Chi-square test was applied to for calculating the proportions of dermoscopic features in LPP and FFA. P- values less than 0.05 were considered statistically significant. Results: Out of 60 articles, 33 (16 LPP, 17 FFA) were considered for quantitative analysis due to availability in English literature with full text. We found that peripilar cylindrical casts and perifollicular redness with arborizing vessels were predominant features suggesting early LPP. In contrast, yellow dots, perifollicular erythema, and scattered pigmentation suggested active FFA. Shiny white area was seen in both groups in the inactive stages. The target arrangement of blue-grey dots, milky-red areas, and irregularly arranged white fibrotic dots were seen in late LPP, and black dots, lonely hairs, and loss of vellus hairs were detected in the later stages of FFA. Features such as blue-grey structureless areas, blue-white veil, and variability in morphologies of hair shafts were nonspecific. Conclusion: This article provides a comprehensive literature review, correlating dermoscopic features with histopathological findings and the similarities, differences, and peculiarities of LPP and FFA.
Navigating University Life: A Qualitative Study of Social and Academic Challenges and Coping Strategies Among Introvert Students in Higher Education
Authors: Shazia Shahzadi*  , Naureen Munir  , Naqeeb Ullah  , Abdul Qayoom Mahar  , Sourath Mahar  
Published: January 2025

This qualitative study investigated the social and academic challenges encountered by introvert university students, aiming to deepen the understanding of their distinct experiences. Through in-depth, semi-structured interviews with 12 undergraduate students from Foundation University in Rawalpindi, the study identified key challenges faced by introverts. Participants expressed that social anxiety, particularly in group discussions and public speaking, led to discomfort and avoidance of activities that interfered with their academic performance. The findings indicated issues related to academic support and social interactions, often resulting in negative self-perceptions and feelings of isolation. Students reported difficulties in connecting with peers, which impacted their engagement with the learning process. Nonetheless, the results revealed that introvert students employed various coping strategies, such as seeking solitude for reflection, utilizing learning environments effectively, and seeking assistance from peers and instructors. The study underscored the necessity for educational institutions to accommodate the diverse needs of introvert students through integrated teaching methods and tailored support programs.
Keywords: Academic challenges, Coping strategies, Introversion, Qualitative study, Social challenges, University students
A Study on the Content Analysis of 5th Grade English Textbook in Punjab, Pakistan
Authors: Muhammad Anwar  , Rashid Mustafa  , Dr. Javed Mustafa  
Published: January 2025

This evaluative study was conducted to analyze the contents of fifth Grade English textbook published by the Punjab Textbook Board. Evaluation of the textbook was done by following Evaluation Criteria presented by Cunnings worth. Evaluation was done through content analysis. Aim of this research was to evaluate strengths and weaknesses regarding its alignment with educational standard. The evaluation identifies three primary weaknesses: inconsistency with Grade five learning levels, complex language structures that may hinder comprehension of fundamental concepts, and limited alignment of reading activities with the four foundational language skills (listening, speaking, reading, and writing). The study also explored decrease students’ motivation and learning outcomes due to vocabulary and grammar structures that exceed the cognitive abilities of typical Grade five learners. This study provides insights for educators and textbook developers to revisit the textbooks and inculcate the materials for enhancing English language instruction and the required language skills necessary for learners at primary level in Punjab.
Key Words: Content Analysis, English Textbook, Fifth grade Level.
“Insights into Behavioral Challenges in ASD Children in Peshawar Autism Centers and Parental Perspectives on its Management: A mixed method study”
Authors: Malak Amanullah Khan  , Hafsa Habib  , Mifrah Rauf sethi  , Shayan Sharif  , M Afaq Khan Yousafzai  
Published: January 2025

Autism spectrum disorder (ASD) is a complex brain development condition that includes repetitive behaviors, limited interests, and challenges with social skills and communication. To understand common behavioral issues in children with autism and to learn how parents view the available treatments and their effectiveness. A mixed method study was conducted on Autistic children in Peshawar Autisms center in which a CBCL questionnaire were filled by parents of total sample 250(Open epi with 95%confidence interval) in first phase within 3 months (Nov/2023-jan/2024) while 20 in-depth interviews of 09 questions were taken from their parents in 2nd phase within 15 days (Feb /2024). Random sampling was used for quantitative data while purposive sampling was used for quantitative data collection. The qualitative data was analyzed using Virginia Braun and Victoria Clarke’s thematic analysis method through NVivo 14, while the quantitative data was analyzed using SPSS 26 for measuring frequency, mean and total score. In all, 250 questionnaires were filled by parents of Autistic children with mean age of 3.5years. Among them the most prevalent behavioral issues were aggression (24%), attention problems (19%), withdrawal (16%), and somatic problems (15%). 44 codes were generated from the qualitative interviews, which further divided into 15 categories and emerged into 4 themes. (1) Parental Challenges in Rearing ASD Children, (2) Goals and Effectiveness of early intervention in ASD, (3) Key Components of Successful Autism Management, (4) Parental Satisfaction & Suggestions. Majority of parents (70%) expressed full satisfaction with the available resources for managing autism, and they have observed improvements in their children's behavior like Attention & verbal communication through various early interventions. In Peshawar, early intervention at autism centers helps manage common behavioral issues aggression and attention issues in autistic children. Parents advise seeking timely support and awareness for better outcomes.
Keywords: Autism Spectrum Disorder; Child; Parent; Therapies.
Biological Alternative Conceptions of Secondary School Students About Heredity: A Case Study
Authors: Farkhanda Iqbal  , Muzammila Akram  
Published: January 2025

Primarily the study is intended to diagnose Alternative conceptions of secondary level student about heredity to comprehend the main ideas of the heredity like cell cycle, mitosis, meiosis. Like vise it also explored the main reasons that develop alternative conceptions. To attain the objectives of the study case study was acquired. Four (4) public schools of Bahawalpur city were selected through random sampling. Formerly 200 students of IX grade were selected as a purposive sample of the research work. A distinct instrument labelled as a diagnostic test to quantify the alternative conceptions about heredity (DT). Renowned and experienced subject specialists of biology authenticated the (DT). To find the reliability a pilot test was intended through test retest method. The coefficient relation (r) was (0.96). To measure the internal consistency of the instrument. the Cronbach alpha coefficient was calculated through SPSS 2026 version; its value was (0.87). On the base of result of diagnostic test interview 50 students were selected purposively. The result indicated that 20% items were concept based. So prior weak knowledge, second language difficulty, poor explanation of lecture created alternative conception. On the base of findings recommendations were proposed e.g. (active participation of learning, use of teaching aids) for better understanding.
Perancangan Inovasi Operasional Menggunakan Pendekatan Blue Ocean Strategy pada Gado Gado Arjuna Pak Satumin
Authors: Suly Trizky Darma Ibrahnovan 
Published: January 2025

Pengelolahan operasional sangat dibutuhkan mengingat persaingan semakin ketat dan pemilik restoran dituntut untuk adaptif. Tidak terkecuali pada industri makanan tradisional atau makanan khas daerah. Restoran menghadapi kesulitan karena harus merespon perubahan permintaan pelanggan, strategi pemasaran dan penjualan. Mengingat perkembangan di industri ini cukup pesat, banyaknya merek-merek baru yang bermunculan yang lebih maju dan kompetitif. Hal ini menunjukkan bahwa diperlukan adanya suatu pengembangan strategis yang bermanfaat untuk mengakselerasi potensi kuliner khas yang dimiliki di kota Surabaya. Objek penelitian ini adalah Gado Gado Arjuna Pak Satumin yang sudah berdiri sejak 1960 yang memiliki nilai historikal yang cukup baik, namun belum memiliki sistem yang strategis pada operasional. Karena itu diperlukan adanya suatu strategi yang dapat digunakan sebagai acuan dari operasinal yang berupa Blue Ocean Strategy. Penelitian ini menggunakan pendekatan kualitatif dengan triangulasi sumber data, jumlah informan sebanyak 5 orang diwakili oleh ekspert dibidang food and beverage. Blue Ocean Strategy terdiri dari SWOT analisis, strategi canvas, ERRC, BOS yang berfokus pada value creation yang dimiliki oleh Gado Gado Arjuna Pak Satumin. Hasil dari penelitian ini berupa Blue Ocean Strategy diimpementasikan di Value Proposition pada Business Model Canvas Gado Gado Arjuna Pak Satumin
Métodos para enseñar la multiplicación y la división de manera efectiva
Authors: Fernández Álava Wendy Dayana , Litardo Zambrano Dayan Mishell , Ronquillo Valencia Leandro David , Vinces Llaguno Leonardo Santiago 
Published: January 2025

La enseñanza de la multiplicación y la división nos enseña enfoques significativos, estrategias pedagógicas bien estructuradas que permitan abordar la complejidad de estos conceptos. Varios escritores sugieren métodos activos para mejorar su aprendizaje, utilizando técnicas lúdicas, ayudas visuales y actividades contextualizadas. Participar en juegos y canciones puede fomentar la motivación y la comprensión, mientras que los estímulos visuales y las técnicas de manipulación ayudan a los estudiantes a comprender los procesos abstractos. Además, integrar las matemáticas en las actividades cotidianas permite a los estudiantes reconocer su valor práctico, lo que conduce a un aprendizaje valioso. El uso de tecnologías y la diferenciación educativa también son significativos, ya que permiten un aprendizaje personalizado y adaptado a las necesidades individuales del alumno. De manera similar, el uso del trabajo en equipo y las evaluaciones formativas fortalece las competencias académicas, sociales y emocionales, promoviendo la empatía y la confianza. En última instancia, un enfoque holístico que combine estrategias pedagógicas innovadoras y un entorno de aprendizaje positivo no sólo mejora la comprensión de la multiplicación y la división, sino que también fomenta una actitud positiva hacia las matemáticas. Enseñar estos conceptos implica no sólo resolver problemas sino también mejorar habilidades fundamentales y preparar a los estudiantes para desafíos futuros con innovación y perseverancia.