bluuebunny/crossref_metadata_2025_split huggingface dataset:
Estado del arte: prácticas evaluativas en producción textual
Authors: Manjarrés Rojas Yudy Alejandra 
Published: December 2023

Este artículo tiene como objetivo fundamental realizar una indagación sobre los estudios realizados a nivel regional (Tolima), nacional (Colombia), e internacional alrededor de la evaluación educativa, las prácticas evaluativas y la producción textual. Al tiempo que, busca fortalecer el trabajo Prácticas evaluativas de la producción textual. Un estudio de caso con docentes del área de castellano de la I.E.T.E. Alberto Castilla de Ibagué, el cual se viene desarrollando para la maestría en Educación de la Universidad del Tolima.
La construcción del estado del arte posibilitó conocer investigaciones finalizadas sobre las categorías en mención, dentro del área de lenguaje, ello, para situar hallazgos positivos y propuestas hechas por docentes e investigadores frente a la evaluación de la escritura en educación básica secundaria. Su realización implicó metodológicamente las siguientes etapas: la búsqueda de información en bases de datos referente a categorías propuestas; compendio de la información suministrada por los textos mediante fichas de sistematización; análisis y sistematización de la información; finalmente, estructuración, revisión y corrección del estado de arte. Ello, permitió establecer una interpretación, contextualización y comprensión de aquellas cuestiones que se convierten en obstáculos para los docentes a la hora de evaluar el factor de producción textual, a su vez, situar vacíos, constantes o tendencias del problema a investigar.
ASUHAN KEBIDANAN KOMPREHENSIF PADA NY.M DI KLINIK UTAMA NILAM SARI TEMBILAHAN TAHUN 2022
Authors: Okta Viarika Dwi , Erlina Asrita Sari Dewi 
Published: December 2023

Comprehensive care is a series of continuous and comprehensive activities, from pregnancy, childbirth, postpartum, newborn services, family planning (KB), which aims to provide quality services to prevent MMR and AKB. This care aims to be able to provide midwifery services Comprehensive Care. The midwifery management approach method with a varney mindset is outlined in the form of SOAP. Held at Nilam Sari Main Clinic on March 11 – June 5, 2022. Comprehensive obstetric care was carried out on Mrs." M" Age 26 Years G3P1A1H1. Based on the results of the upbringing, ANC went well, the maternity went well, when I lasted for 23 hours, when II lasted for 15 minutes, when III lasted for 15 minutes, and when IV lasted for 2 hours. Babies are born spontaneously, neonatal visits are carried out as much as 3x. The postpartum period went normally, 4x postpartum visits and Mrs. family planning care." M" chose 3-month injectable birth control. There was a gap in the schedule of ANC visits and methergin, from these results it can be concluded that comprehensive care was given to Mrs." M" already meets the standard. It is hoped that the results of this midwifery care can be an input for female students in improving the quality of midwifery care services for pregnant women, childbirth, BBL, postpartum and family.

Asuhan komprehensif merupakan serangkaian kegiatan yang berkelanjutan dan menyeluruh, dari kehamilan, persalinan, nifas, pelayanan bayi baru lahir, keluarga berencana (KB), Yang bertujuan untuk memberikan pelayanan yang berkualitas untuk mencegah terjadinya AKI dan AKB. Asuhan ini bertujuan Mampu memberikan pelayanan kebidanan Asuhan Komprhensif. Adapun Metode pendekatan manajemen kebidanan dengan pola fikir varney yang dituangkan dalam bentuk SOAP. Dilaksanakan di Klinik Utama Nilam Sari pada tanggal 11 Maret – 05 Juni 2022. Asuhan kebidanan komprehensif dilakukan pada Ny.”M” Umur 26 Tahun G3P1A1H1. Bedasarkan hasil asuhan, ANC berjalan dengan baik, ibu bersalin berjalan dengan baik, kala I berlangsung selama 23 jam, kala II berlangsung selama 15 menit, kala III berlangsung selama 15 menit, dan kala IV berlangsung selama 2 jam. Bayi lahir spontan, dilakukan kunjungan neonatus sebanyak 3x. Masa nifas berjalan normal, kunjungan nifas sebanyak 4x dan asuhan keluarga berencana Ny.”M” memilih KB suntik 3 bulan. Terdapat kesenjangan pada jadwal kunjungan ANC dan pemberian methergin, dari hasil tersebut dapat disimpulkan bahwa asuhan komprehensif yang diberikan pada Ny.”M” sudah memenuhi standar. Diharapkan dari hasil asuhan kebidanan ini, dapat menjadi masukan bagi mahasiswi dalam meningkatkan mutu pelayanan asuhan kebidanan pada ibu hamil, persalinan, BBL, nifas dan keluarga.
Toiseutettujen epäuskottaviksi väitetyt tarinat
Authors: Puranen-Impola Karoliina 
Published: December 2023

Tässä artikkelissa tarkastelen lastensuojelun sijaishuollossa tapahtuneesta kaltoinkohtelusta julkaistua lehdistökirjoittelua. Artikkelin aineiston muodostavat Kansalliskirjaston digitaaliarkistoon tallennetut lehtiartikkelit, joissa kirjoitettiin lastensuojelussa ilmenneestä kaltoinkohtelusta noin vuosina 1948–2020. Artikkelissa osoitan, että kaltoinkohtelutapauksia nousi julkisuuteen erityisesti 1950-luvulla. Ilmiötä ei kuitenkaan saatu kitkettyä, ja sijaishuollossa tapahtunutta kaltoinkohtelua on ilmennyt vielä 2000-luvullakin. Analysoin artikkelissa niitä reittejä, joita pitkin tapaukset ovat nousseet laajempaan tietoisuuteen sekä tarkastelen tekijöitä, jotka ovat mahdollisesti osaltaan tuottaneet ilmiön ympärillä vallinnutta hiljaisuutta. Kiinnitän huomiota myös siihen, missä määrin sijoitettuja lapsia ja heidän tarinaansa on toiseutettu ja marginalisoitu. Pohdin, miten toiseuttaminen osaltaan vaikutti kaltoinkohtelun ympärillä vallinneeseen hiljaisuuteen sekä sen pitkittyneeseen luonteeseen.
CXCL10-based gene cluster model serves as a potential diagnostic biomarker for premature ovarian failure
Authors: Qin Ying , Wen Canliang , Wu Huijiao 
Published: December 2023

Objective
Premature ovarian failure (POF) is a disease with high clinical heterogeneity. Subsequently, its diagnosis is challenging. CXCL10 which is a small signaling protein involved in immune response and inflammation may have diagnostic potential in detection of premature ovarian insufficiency. Therefore, this study aimed to investigate CXCL10 based diagnostic biomarkers for POF.

Methods
Transcriptome data for POF was obtained from the Gene Expression Omnibus (GEO) database (GSE39501). Principal component analysis (PCA) assessed CXCL10 expression in patients with POF. The receiver operating characteristic (ROC) curve, analyzed using PlotROC, demonstrated the diagnostic potential of CXCL10 and CXCL10-based models for POF. Differentially expressed genes (DEGs) in the control group of POF were identified using DEbylimma. PlotVenn was used to determine the overlap between the POF-control group and the high-/low-expression CXCL10 groups. QuadrantPlot was employed to detect CXCL10-dysregulated genes in POF. Gene Ontology (GO), Kyoto Encyclopedia of Genes and Genomes (KEGG), and Gene Set Enrichment Analysis (GSEA) were conducted on DEGs using RunMulti Group cluster Profiler. A POF model was induced with cisplatin (DDP) using KGN cells. RT-qPCR and Western blot were used to measure the expression of CXCL10, apoptosis-related proteins, and peroxisome proliferator–activated receptor (PPAR) signaling pathway-related proteins in this model, following siRNA-mediated silencing of CXCL10. Flow cytometry was employed to assess the apoptosis of KGN cells after CXCL10 downregulation.

Results
The expression of CXCL10 is dysregulated in POF, and it shows promising diagnostic potential for POF, as evidenced by an area under the curve value of 1. In POF, we found 3,362 up-regulated and 3,969 down-regulated DEGs compared to healthy controls, while the high- and low-expression groups of POF (comprising samples above and below the median CXCL10 expression) exhibited 1,304 up-regulated and 1,315 down-regulated DEGs. Among these, 786 DEGs consistently displayed dysregulation in POF due to CXCL10 influence. Enrichment analysis indicated that the PPAR signaling pathway was activated by CXCL10 in POF. The CXCL10-based model (including CXCL10, Itga2, and Raf1) holds potential as a diagnostic biomarker for POF. Additionally, in the DDP-induced KGN cell model, interfering with CXCL10 expression promoted the secretion of estradiol, and reduced apoptosis. Furthermore, CXCL10 silencing led to decreased expression levels of PPARβ and long-chain acyl-CoA synthetase 1 compared to the Si-NC group. These results suggest that CXCL10 influences the progression of POF through the PPAR signaling pathway.

Conclusion
The CXCL10-based model, demonstrating perfect diagnostic accuracy for POF and comprising CXCL10, Itga2, and Raf1, holds potential as a valuable diagnostic biomarker. Thus, the expression levels of these genes may collectively provide valuable diagnostic information for POF.
The Prevalence of Candida Species among HIV-Positive Women in Aluu, Nigeria: A Call for Awareness
Authors: Cookey T. I.  , Ihejirika M. O.  , Osuala O. J.  , Onu, E. N.  , Amadi, B. O.  , Oketah, E. N.  , Adim, C. C.  , Innocent-Adiele H. C.  , Okonko I. O.  
Published: December 2023

Background: The acquired immune deficiency syndrome (AIDS), which HIV brings on, is a major public health concern. The human immunodeficiency virus (HIV) is still a pandemic. Only 2.1% of HIV cases worldwide are recorded in Nigeria. Usually, under the control of the immune system, Candida infections may be dangerous for immunocompromised people, particularly those living with HIV/AIDS.
Aim: At the Mbodo Health Centre in Aluu, Rivers State, Nigeria, this study aimed to assess the prevalence of Candida infections and their relationship to HIV-positive patients.
Methods: Fifty HIV-positive women were chosen at random. Self-collected oral and vaginal swabs were used to gather data. To identify Candida species, biochemical testing, culture, and microscopy were used.
Results: Eighty percent of the 50 individuals had positive candidiasis tests. Oral and vaginal mono/co-candidiasis were found to be common, with Candida albicans being the most common specie. Based on demographic parameters, statistical analysis did not show a significant difference in the prevalence of oral candidiasis. The frequency of vaginal candidiasis was much greater in those with secondary education and aged 31-40 years. The age group of 31 to 40 years old had a considerably greater co-occurrence rate of oral and vaginal candidiasis. Adult female HIV-positive patients at Mbodo Health Centre have a significant prevalence of candidiasis.
Conclusion: The study sheds light on the distribution of Candida species and how demographic variables relate to them. These results highlight the significance of treating candidiasis as a serious health issue in people living with HIV. To improve overall health outcomes for HIV-positive people and reduce related risk factors, further research and treatments may be required.
Benign Breast Disease and Breast Cancer Risk in the Percutaneous Biopsy Era
Authors: Sherman Mark E. , Vierkant Robert A. , Winham Stacey J. , Vachon Celine M. , Carter Jodi M. , Pacheco-Spann Laura , Jensen Matthew R. , McCauley Bryan M. , Hoskin Tanya L. , Seymour Lisa , Gehling Denice , Fischer Jessica , Ghosh Karthik , Radisky Derek C. , Degnim Amy C. 
Published: December 2023

ImportanceBenign breast disease (BBD) comprises approximately 75% of breast biopsy diagnoses. Surgical biopsy specimens diagnosed as nonproliferative (NP), proliferative disease without atypia (PDWA), or atypical hyperplasia (AH) are associated with increasing breast cancer (BC) risk; however, knowledge is limited on risk associated with percutaneously diagnosed BBD.ObjectivesTo estimate BC risk associated with BBD in the percutaneous biopsy era irrespective of surgical biopsy.Design, Setting, and ParticipantsIn this retrospective cohort study, BBD biopsy specimens collected from January 1, 2002, to December 31, 2013, from patients with BBD at Mayo Clinic in Rochester, Minnesota, were reviewed by 2 pathologists masked to outcomes. Women were followed up from 6 months after biopsy until censoring, BC diagnosis, or December 31, 2021.ExposureBenign breast disease classification and multiplicity by pathology panel review.Main OutcomesThe main outcome was diagnosis of BC overall and stratified as ductal carcinoma in situ (DCIS) or invasive BC. Risk for presence vs absence of BBD lesions was assessed by Cox proportional hazards regression. Risk in patients with BBD compared with female breast cancer incidence rates from the Iowa Surveillance, Epidemiology, and End Results (SEER) program were estimated.ResultsAmong 4819 female participants, median age was 51 years (IQR, 43-62 years). Median follow-up was 10.9 years (IQR, 7.7-14.2 years) for control individuals without BC vs 6.6 years (IQR, 3.7-10.1 years) for patients with BC. Risk was higher in the cohort with BBD than in SEER data: BC overall (standard incidence ratio [SIR], 1.95; 95% CI, 1.76-2.17), invasive BC (SIR, 1.56; 95% CI, 1.37-1.78), and DCIS (SIR, 3.10; 95% CI, 2.54-3.77). The SIRs increased with increasing BBD severity (1.42 [95% CI, 1.19-1.71] for NP, 2.19 [95% CI, 1.88-2.54] for PDWA, and 3.91 [95% CI, 2.97-5.14] for AH), comparable to surgical cohorts with BBD. Risk also increased with increasing lesion multiplicity (SIR: 2.40 [95% CI, 2.06-2.79] for ≥3 foci of NP, 3.72 [95% CI, 2.31-5.99] for ≥3 foci of PDWA, and 5.29 [95% CI, 3.37-8.29] for ≥3 foci of AH). Ten-year BC cumulative incidence was 4.3% for NP, 6.6% for PDWA, and 14.6% for AH vs an expected population cumulative incidence of 2.9%.Conclusions and RelevanceIn this contemporary cohort study of women diagnosed with BBD in the percutaneous biopsy era, overall risk of BC was increased vs the general population (DCIS and invasive cancer combined), similar to that in historical BBD cohorts. Development and validation of pathologic classifications including both BBD severity and multiplicity may enable improved BC risk stratification.
Trim21 Regulates the Postnatal Development and Thermogenesis of Brown Adipose Tissue
Authors: Hu Qinxiao , Xu Yidi , Xiao Teng , Peng Rui , Li Zhenwei , Xu Guisheng , Yu Bo , Li Jianping , Li Zhen‐Yan , Hou Huige , Lin Yuning , Cao Jiahui , Liu Ning , Zha Zhen‐Gang , Gui Tao , Zhang Huan‐Tian , Cai Yuebo 
Published: December 2023

AbstractBrown adipose tissue undergoes rapid postnatal development to mature and plays a crucial role in thermoregulation and energy expenditure, which protects against cold and obesity. Herein, it is shown that the expression of Trim21 mRNA level of interscapular brown adipose tissue elevates after birth, and peaks at P14 (postnatal day 14). Trim21 depletion severely impairs the maturation of interscapular brown adipose tissue, decreases the expression of a series of thermogenic genes, and reduces energy expenditure. Consistently, the loss of Trim21 also leads to a suppression of white adipose tissue “browning”, in response to cold exposure and a β‐adrenergic agonist, CL316,243. In addition, Trim21−/− mice are more prone to high‐fat diet‐induced obesity compared with the control littermates. Taken together, the study for the first time reveals a critical role of Trim21 in regulating iBAT postnatal development and thermogenesis.
Cascade Bioreactors Based on Host–Guest Molecular Inclusion Complexes for Triple‐Negative Breast Cancer Therapy via Inducing Ferroptosis
Authors: Jia Zengguang , Zhang Jun , Wei Yawen , Pan Xiuhua , Hu Zongwei , Kang Ruixin , Zhou Xiawei , Shen Qi 
Published: December 2023

AbstractTriple‐negative breast cancer (TNBC) poses significant challenges in tumor treatment. Ferroptosis, as a novel cell death mechanism, holds promise as a potential therapeutic strategy for TNBC. In this study, cascade bioreactors based on host–guest molecular inclusion complexes (PCFP@PL/p53) are constructed for TNBC therapy via inducing ferroptosis. The bioreactors are composed of hydrophobic hemirotaxane (mPEG‐β‐CD/α‐CD) and hydrophilic multi‐branched polyethyleneimine‐ferrocene (PEI‐Fc). They are linked by the reactive oxygen species (ROS)‐responsive molecular switch β‐CD@Fc, which can be activated by high levels of ROS. This activation leads to the rapid disassembly of PCFP@PL/p53 and the subsequent release of the loaded piperlongumine (PL) and p53 plasmids. In addition to acting as a “switch,” Fc can react with hydrogen peroxide (H2O2) in a Fenton reaction to produce hydroxyl radicals. PL decreases intracellular reduced glutathione and induces H2O2 accumulation, which corporates with Fc to launch ferroptosis and activated p53. The activated p53 disrupts the SLC7A11‐GSH‐GPX4 pathway, further increasing the intracellular ROS levels, resulting in a cascade amplification of ROS that ultimately induces massive ferroptosis. Meanwhile, the PCFP@PL/p53‐induced ferroptosis also activates the immune system in vivo, restricting the growth and metastasis of TNBC, thus providing a novel approach for TNBC therapy based on ferroptosis.
Superionic Conductor Enabled Composite Lithium with High Ionic Conductivity and Interfacial Wettability for Solid‐State Lithium Batteries
Authors: Li Zongyang , Zheng Weikang , Lu Guanjie , Li Menghong , Tang Desha , Zhao Qiannan , Wang Yumei , Xu Chaohe , Wang Ronghua 
Published: December 2023

AbstractThe urgent demand for high energy and safety batteries has generated the rapid development of Li6.4La3Zr1.4Ta0.6O12 (LLZTO) type solid‐state lithium metal batteries. However, severe dendritic lithium growth, which is caused by poor interfacial contact of the Li/LLZTO interface and loss of electrical contact during cycles due to low intrinsic Li+ diffusion coefficient of lithium, greatly hampers its practical application. Here, from the point of view of reducing surface tension and improving ion diffusion of lithium, a composite lithium anode (CLA) with high wettability and ion diffusion coefficient is prepared by adding GaP into molten lithium, thus strengthening the CLA/LLZTO interface even in cycling. As envisioned, compared to pure lithium, CLA presents lower surface tension, larger adhesion work, and higher ion diffusion coefficient, ensuring close contact of the CLA/LLZTO interface. Therefore, the assembled symmetric cells exhibit a low area specific resistance of 4.5 Ω cm2, a large critical current density of 2.5 mA cm−2, and ultra‐long lifespan of 5700 h at 0.3 mA cm−2 at 25 °C. Meanwhile, full cells coupled with LiFePO4 cathode show a high‐capacity retention of 97.32% after 490 cycles at 1C. This work provides a new solution to the interfacial challenges of solid‐state lithium‐metal batteries.
Bi‐Oriented Step Guided Nucleation and Epitaxy of Twist Bilayer Graphene with Precisely Controlled Twist Angle
Authors: Dong Ruikang , Gong Xiaoshu , Yang Jiafu , Sun Yueming , Wang Jinlan , Ma Liang 
Published: December 2023

AbstractTwist bilayer graphene (tBLG) with a small magic angle deviated from trivial stacking exhibits fantastic electronic properties. However, the growth of large‐area tBLG with precisely controlled twist angle remains a grand challenge due to the thermodynamically unfavorable nucleation. Here, a bi‐oriented step‐guided strategy is theoretically proposed for the nucleation and epitaxial growth of tBLG, where the twist angle can be predetermined by the orientations of adjacent steps owing to the covalent alignment between the steps and graphene zigzag edges. The presence of bi‐oriented steps can greatly reduce the free energy of the tBLG with matched twist angle, thus promoting the nucleation priority of tBLG. Importantly, it is shown that the 28 sets of bi‐oriented steps with twist angles of 1.5°–30° can be intentionally constructed via two‐step miscutting from bulk crystal of catalytic metals by exploring all potential combinations of bi‐steps on different epitaxial surfaces. The employment of either low‐temperature CVD growth with certain precursors or the high‐melting‐point metal substrates is suggested to against the reconstruction of bi‐oriented steps during growth. This work demonstrates an efficient scheme for the epitaxial growth of large‐area tBLG with pre‐designed twist angle, which can be potentially extended to the growth of other twist 2D materials.
Phase Change Materials‐Based Bilayer Metasurfaces for Near‐Infrared Photonic Routing
Authors: Li Chensheng , Du Shuo , Pan Ruhao , Xiong Xiaoyu , Tang Zhiyang , Zheng Ruixuan , Liu Yunan , Geng Guangzhou , Sun Jingbo , Gu Changzhi , Guo Haiming , Li Junjie 
Published: December 2023

AbstractPhotonic routing holds immense significance in the fields of photonic integrated circuits (PICs) for free‐space optical linking. The emergence of programmable metasurfaces with powerful phase regulation capability provides a promising strategy for achieving designated wavefront modulation and thus photonic routing in the optical communication waveband. Here, a bilayer metasurfaces with four‐level codable unit pixels, which realize controllable photonic routing in near‐infrared (NIR) region is reported. The unit pixel of the metasurfaces consists of the underneath amorphous silicon (α‐Si) nanofin and the upper Ge2Sb2Te5 (GST) nano‐antenna, which contribute to the cross‐polarization generation and amplitude modulation of cross‐polarization light, respectively. Each unit pixel can be designated with desired states, thus achieving on‐demand non‐volatile photonic routing for coherent NIR light. In particular, polarization conversion modulation of the tunable metasurfaces comprising identical unit cell with large cross‐polarization switching (≈55%) at ≈1550 nm is demonstrated. Moreover, the metasurfaces with coded unit pixels to realize designated photonic routing are prototyped. The metasurfaces with four‐level programmability portend a new paradigm in NIR photonic routing for PICs.
Sound Continuous Production of Thermosets
Authors: Yao Guang , Xiang Hongping , Lucas Margaret , Gao Hang , Zheng Lijuan , Wu Dandan , Han Zexi , Lai Jianhua , Wang Chengyong 
Published: December 2023

AbstractExisting manufacturing technologies for thermoset components are limited by long cycle times, simple structures, limited material, and poor controllability, making it difficult to realize complex structures with functionally graded properties. Herein, a sound continuous production (SCP) technology is proposed for the rapid manufacture of thermosets by accelerating the gelation through the mechanical, physical, and chemical effects of ultrasound. SCP is shown to enable the continuous production of homogeneous and heterogeneous thermosets. Its combination with a robotic arm allows for 360° omnidirectional continuous production, which is demonstrated by the successful construction of lateral and vertical‐oriented spiral structures via unsupported fabrication. Multiscale filaments with diameters ranging from 150 µm to 2 cm are manufactured and are shown capable of producing functionally graded materials with mechanical property gradients of up to five. The direct fabrication via SCP of a set of functional composites is demonstrated and a novel fabrication technique for multilayer carbon fiber‐reinforced plastic laminates is presented. This method can bring technological innovation to the rapid manufacture of thermosets for several emerging fields.