bluuebunny/crossref_metadata_2025_split huggingface dataset:
CaCO3Nanoparticles Delivering MicroRNA-200c Suppress Oral Squamous Cell Carcinoma
Authors: Ding Qiong J , Remy Matthew T. , Upara Chawin , Hu Jue , Mata Andrés V. Mora , Haes Amanda J. , Lanzel Emily , Sun Hongli , Buchakjian Marisa R. , Hong Liu 
Published: October 2023

AbstractMicroRNA (miR)-200c suppresses the initiation and progression of oral squamous cell carcinoma (OSCC), the most prevalent head and neck cancer with high recurrence, metastasis, and mortality rates. However,miR-200c-based gene therapy to inhibit OSCC growth and metastasis has yet to be reported. To develop an miR-based gene therapy to improve the outcomes of OSCC treatment, this study investigates the feasibility of plasmid DNA encodingmiR-200cdelivered via non-viral CaCO3-based nanoparticles to inhibit OSCC tumor growth. CaCO3-based nanoparticles with various ratios of CaCO3and protamine sulfate (PS) were utilized to transfect pDNA encodingmiR-200cinto OSCC cells and the efficiency of these nanoparticles was evaluated. The proliferation, migration, and associated oncogene production, as well asin vivotumor growth for OSCC cells overexpressingmiR-200cwere also quantified. It was observed that, while CaCO3-based nanoparticles improve transfection efficiencies of pDNAmiR-200c, the ratio of CaCO3to PS significantly influences the transfection efficiency. Overexpression ofmiR-200csignificantly reduced proliferation, migration, and oncogene expression of OSCC cells, as well as the tumor size of cell line-derived xenografts (CDX) in mice. In addition, a local administration of pDNAmiR-200cusing CaCO3delivery significantly enhancedmiR-200ctransfection and suppressed tumor growth of CDX in mice. These results strongly indicate that the nanocomplexes of CaCO3/pDNAmiR-200cmay potentially be used to reduce oral cancer recurrence and metastasis and improve clinical outcomes in OSCC treatment. (227 words)
Promoting sustainable learning among accounting students: evidence from field experimental design
Authors: Hadi Noor Ul , Abdel-Razzaq Assim Ibrhaim 
Published: October 2023

PurposeSeveral studies have attempted to explain the integration of sustainable development in business school curricula. However, little is known about who (male students vs female students), at which age (under 21, 21–25 and 26–30) and at which stage of their undergraduate education (freshman, junior or senior) can attain and retain an adequate understanding of sustainability in accounting education. For this reason, the present study aims to investigate the students' interest in sustainability in accounting with respect to their demographic factors.Design/methodology/approachThe study used a quantitative research design where data were collected at a single point in time. Further, an independent sample t-test, one-way ANOVA and factorial design were performed on 132 responses conveniently collected from accounting students in the College of Business Administration (COBA) at Prince Mohammad Bin Fahd University (PMU) in Al Khobar, Saudi Arabia.FindingsThe study found no differences between the attitudes of male and female students toward sustainability in accounting education. Similarly, no statistical differences were found in the three age categories identified in this study. However, significant results were found throughout the different academic classifications (seniority): freshman students, junior students and senior students. Further, differences in the mean scores for freshman and junior accounting students were different between the male and female students, indicating that both male and female senior students' attitudes toward sustainability in accounting education were higher than those of male and female freshman and junior accounting students. The study concluded that students achieve an adequate understanding of sustainability in accounting education related to the relativism category of the Perry model of intellectual development.Originality/valueLiterature on attitude of students toward sustainability in education, specifically accounting education, is questionable and needs further exploration. This is due to the fact that only a small number of accounting students have been exposed to sustainable accounting education. Similarly, a recent study found a significant deficiency in sustainable accounting education in four Saudi Arabian universities, with only 4.5% of respondents knowing the comprehensive definition of sustainable development and 88% respondents having very low to low familiarity with the term sustainability.
Brand new: how visual context shapes initial response to logos and corporate visual identity systems
Authors: Wertz Robert A. 
Published: October 2023

Purpose
When a new logo is released, it does not have an established meaning in the mind of the viewer. As logos have become more highly scrutinized by consumers and critics, it has become more important to understand viewers’ initial responses to logos. While other studies have researched the impact of aesthetic choices on viewer reaction to logos, this study aims to understand the effect of the surrounding visual identity system when a new logo is introduced.

Design/methodology/approach
This study combines a content analysis of 335 posts on the logo review website Brand New with the voting data from their polls to understand how visual context correlates with a viewer’s initial response.

Findings
Increased amounts of visual context correlate to an improved response from viewers. Different types of context that can be presented – from logo variations and environmental examples to videos and animation – have varied effects.

Practical implications
When releasing a new logo, companies and organizations may receive a better response from viewers if they provide more visual context. Animations may also provide an improved response.

Originality/value
This study takes a novel approach to exploring viewer responses to logos by combining content analysis with voting data. While most studies use fictitious or abstract logo designs, this study uses actual logos and context to better understand viewer responses.
When frontline robots emerge: the double-edged-sword effect of anticipated trust on intention to switch brands after service failure
Authors: Cui Jinsheng , Zhang Mengwei , Zhong Jianan 
Published: October 2023

PurposeThis research aims to investigate the influence of consumers' anticipated trust in service providers on brand switching intention and its underlying psychological mechanism. More importantly, this study explores the moderating role of type of service providers (human staff/humanoid robots/nonhumanoid robots).Design/methodology/approachThis study adopted two single-factor between-subjects experimental designs and tested the hypotheses in two typical service failure scenarios: Study 1, a hotel scenario (N = 403); and Study 2, a restaurant scenario (N = 323).FindingsThe results suggest that there is an inverted U-shaped relationship between consumers' anticipated trust and tolerance of service failure and that such tolerance has a mediating effect on the relationship between anticipated trust and brand switching intention. Moreover, when service failure is caused by a humanoid service robot, a moderate anticipated trust level of consumers is most conducive to increasing tolerance, which in turn reduces their propensity to switch brands.Originality/valueThis study examines the nature of the relationship between anticipated trust and tolerance in a service failure context, revealing an inverted U-shaped relationship. More importantly, the boundary conditions under which different service provides have an influence on this relationship are incorporated. Finally, this study explores the influence of service failure tolerance on brand switching intentions in a technological context, enriching consumer–brand relationship research.
Gender diversity effects on investment decisions: a study of Shark Tank
Authors: Hussain Shahid , Rasheed Abdul , Mahmood Mahmoona 
Published: October 2023

PurposeThis paper investigates gender disparity in investment decisions within the popular American TV show Shark Tank.Design/methodology/approachThe research uses a comprehensive dataset of 925 pitches from 14 seasons and 316 episodes, covering August 2009 to May 2023.FindingsContrary to previous studies, the findings indicate that female entrepreneurs do n'ot face discrimination in terms of their pitching success rates, regardless of their industry affiliation. However, the authors did observe that female entrepreneurs tend to receive lower valuations, both self-assessed and in final deals. This suggests a self-imposed gender gap in venture capital and angel investing, likely stemming from lower entrepreneurial aspirations among women.Originality/valueTo tackle this issue, the authors propose promoting female venture capital by increasing the representation of female entrepreneurs and business angels on Shark Tank. Such role models can inspire aspiring women in these fields. Additionally, the authors believe that mixed-gender founder teams, comprising both men and women, can play a significant role in developing promising startups with viable business models.
Post-adversarial appreciation: a novel re-conceptualisation of posttraumatic growth
Authors: Harding-White Madison , Mojtahedi Dara , Carson Jerome 
Published: October 2023

PurposeThis paper aims to explore current inconsistencies within the theoretical framework of current posttraumatic growth (PTG) literature in support of the suggestion for an alternative novel phenomenon labelled “post-adversarial appreciation”.Design/methodology/approachThis re-conceptualisation has developed from the findings of empirical research conducted by the authors and their understanding of PTG.FindingsSignificant inconsistencies persist across the PTG literature in relation to the parameters required for PTG to manifest. It appears that PTG or an alternative concept labelled adversarial growth does take place following adverse/traumatic events, but that a separate phenomenon may better explain positive improvements in perceived personal appreciation during such events. This phenomenon is theorised by the authors as “post-adversarial appreciation”.Originality/valueThis paper suggests the existence of a novel phenomenon that may address many of the inconsistencies and present within the current PTG literature. This highlights a significant need for further research within the field of trauma and adversity in relation to positive outcomes which may result from such negative experiences.
Do ties still bind? Analyst behaviour after financial restatements
Authors: Wu Yi (Ava) , Kuang Yu Flora , Lee Gladys , Zhai Kerui 
Published: October 2023

AbstractWe find that, compared to non‐connected analysts, analysts with professional connections to a coverage firm (i.e., connected analysts) are more likely to continue covering the firm after it issues a restatement. Furthermore, connected analysts are more likely to issue pessimistic earnings forecasts and to downgrade stock recommendations for the firm after its financial restatement. Our results also reveal the costs and benefits associated with connected analysts' pessimism – a reduced market reaction to the analysts' pessimistic research on the restating firm, and a positive effect on the market's perception of the quality of the analysts' research on non‐restating firms.
Emergency presentations for older persons with low back pain: An increasing clinical and economic challenge
Authors: Ellem Rod , Pickering Rowan , Marks Darryn , Todd James , Brown Jarryd , Roberts Shelley , Michaleff Zoe A. 
Published: October 2023

AbstractObjectiveTo determine whether differences exist for older persons presenting to Emergency Departments (EDs) with lower back pain (LBP) in terms of management, health service resource use and cost when compared to younger patients with LBP.MethodsRetrospective analysis of routinely collected electronic medical record data from January 2015 to July 2021. Data from 11,098 adults presenting with LBP to two large regional Australian EDs were analysed over a 5‐year period. Rates of presentation, investigation, medication use, spinal surgery and cost were assessed for all participants with respect to age groups (over or under 65 years of age), diagnosis and time. Multivariable logistic regression analysis was employed to assess the contribution of presentation characteristics to the risk of inpatient admission and to investigate the variable effect of patient age.ResultsOlder people represented 23% (n = 2565) of all LBP presentations, with a growing proportion of presentations over time. More than 1 in 4 patients over 65 were admitted (n = 703, 27%), with CT imaging being proportionately three times more prevalent (24% vs. 6%), and average cost double (AU$3973 vs. $1671) that of the younger population. Consultation by an ED physiotherapist was associated with lower admission risk across all adult presentations (OR 0.52, 95% CI [0.40 to 0.67]).ConclusionsOlder persons are over‐represented amongst gradually increasing rates of LBP presentations to EDs and associated with escalating cost of care and hospital resource use. Older patients present a different clinical and economic profile to younger patients, supporting the provision of individualised management recommendations.
Treatment burden on patients receiving intravitreal anti‐VEGF for wet age‐related macular degeneration
Authors: Vinge Erik , Bro Tomas 
Published: October 2023

AbstractPurposeThe aim of this study was to map the treatment burden for patients with wet age‐related macular degeneration (wAMD).MethodPatients with ongoing treatment with anti‐VEGF for wAMD at a Swedish eye unit underwent a survey about the time spent receiving treatment, caregiver assistance, way of transportation, self‐rated vision and negative experiences associated with the treatment such as discomfort, anxiety or transportation problems. Information about current visual acuity, number of treatments and current treatment intervals were obtained from medical records.ResultsThe study included 93 patients with an average age of 79.9 years, 68% were women. The average interval between treatments was 7.3 weeks, and 26% had active treatment in both eyes. On average, patients had to spend 2.7 h (2.4–2.9: 95% CI) per treatment and a caregiver assisted the patient in 58% of cases. Caregivers spent on average 2.6 h (2.5–2.8: 95% CI) per visit, and 19% needed to take time off work. The majority (91%) of patients did not experience any transportation problems associated with treatment. A multivariate logistic regression analysis showed a significantly lower odds ratio for discomfort with higher self‐rated vision and a significantly higher odds ratio for discomfort with longer treatment intervals.DiscussionAnti‐VEGF treatment is an effective treatment for wAMD. However, the relatively short treatment intervals place a considerable burden on patients and their relatives regarding time. Although the patients in this study had to spend a lot of time to receive treatment, the majority did not experience any problems associated with treatment.
Finnish paediatric study found a low incidence of bacterial meningitis from 2011 to 2018 but a substantial proportion of nosocomial meningitis
Authors: Niemelä Sakke , Lempinen Laura , Löyttyniemi Eliisa , Grönroos Juha O. , Luoto Raakel , Peltola Ville , Jero Jussi 
Published: October 2023

AbstractAimThis study examined the predisposing factors, clinical picture, bacterial aetiology and clinical outcomes of infants and children with bacterial meningitis (BM).MethodsThe medical records of patients under 16 years of age, treated by Turku University Hospital, Finland, from 2011 to 2018, were screened for meningitis using the International Classification of Diseases, Tenth Revision codes. Patients were included if bacteria were detected in cerebrospinal fluid (CSF) or other predefined laboratory variables indicated BM, despite CSF testing negative for bacteria. The Glasgow Outcome Scale (GOS) was used to determine outcomes.ResultsWe identified 37 children with BM: 22 infants aged 0–89 days and 15 children aged 90 days to 15 years. The overall incidence was approximately 5.7/100 000/year. Nosocomial meningitis was documented in 51%. Bacterial growth was detected in the CSF or blood cultures of the majority of patients (57%). Escherichia coli (14%), group B streptococcus (11%) and Streptococcus pneumoniae (8%) were the most common pathogens. There were 14% of patients with unfavourable outcomes, namely GOS scores of 1–4, but no deaths.ConclusionThe incidence of paediatric BM was low during the study period, but the proportion of nosocomial meningitis was substantial. The frequency of unfavourable long‐term outcomes was relatively low.
Alaska's ban on sentence bargaining
Authors: McCannon Bryan C. 
Published: October 2023

AbstractPlea bargaining dominates the U.S. criminal justice system and has garnered calls to reduce its prevalence. In 2013 Alaska's Attorney General acted banning a practice known as sentencing bargaining where the prosecutor negotiates with the defense over the length of the incarceration. I provide the first causal identification of this policy's impact on the plea bargaining rate. I show that the policy, by leaving open the charging discretion (in effect allowing charge bargaining), was ineffective at changing plea bargaining's prevalence across the state. Policymakers should look elsewhere for tools if they want to mitigate its rate.
Plasma neurofilament light chain predicts Alzheimer's disease in patients with subjective cognitive decline and mild cognitive impairment: A cross‐sectional and longitudinal study
Authors: Mazzeo Salvatore , Ingannato Assunta , Giacomucci Giulia , Manganelli Alberto , Moschini Valentina , Balestrini Juri , Cavaliere Arianna , Morinelli Carmen , Galdo Giulia , Emiliani Filippo , Piazzesi Diletta , Crucitti Chiara , Frigerio Daniele , Polito Cristina , Berti Valentina , Bagnoli Silvia , Padiglioni Sonia , Sorbi Sandro , Nacmias Benedetta , Bessi Valentina 
Published: October 2023

AbstractBackground and purposeWe aimed to evaluate the accuracy of plasma neurofilament light chain (NfL) in predicting Alzheimer's disease (AD) and the progression of cognitive decline in patients with subjective cognitive decline (SCD) and mild cognitive impairment (MCI).MethodsThis longitudinal cohort study involved 140 patients (45 with SCD, 73 with MCI, and 22 with AD dementia [AD‐D]) who underwent plasma NfL and AD biomarker assessments (cerebrospinal fluid, amyloid positron emission tomography [PET], and 18F‐fluorodeoxyglucose‐PET) at baseline. The patients were rated according to the amyloid/tau/neurodegeneration (A/T/N) system and followed up for a mean time of 2.72 ± 0.95 years to detect progression from SCD to MCI and from MCI to AD. Forty‐eight patients (19 SCD, 29 MCI) also underwent plasma NfL measurements 2 years after baseline.ResultsAt baseline, plasma NfL detected patients with biomarker profiles consistent with AD (A+/T+/N+ or A+/T+/N−) with high accuracy (area under the curve [AUC] 0.82). We identified cut‐off values of 19.45 pg/mL for SCD and 20.45 pg/mL for MCI. During follow‐up, nine SCD patients progressed to MCI (progressive SCD [p‐SCD]), and 14 MCI patients developed AD dementia (progressive MCI [p‐MCI]). The previously identified cut‐off values provided good accuracy in identifying p‐SCD (80% [95% confidence interval 65.69: 94.31]). The rate of NfL change was higher in p‐MCI (3.52 ± 4.06 pg/mL) compared to non‐progressive SCD (0.81 ± 1.25 pg/mL) and non‐progressive MCI (−0.13 ± 3.24 pg/mL) patients. A rate of change lower than 1.64 pg/mL per year accurately excluded progression from MCI to AD (AUC 0.954).ConclusionPlasma NfL concentration and change over time may be a reliable, non‐invasive tool to detect AD and the progression of cognitive decline at the earliest stages of the disease.
Customer preference analysis towards online shopping decisions based on optimized feature extraction
Authors: Liu Weiguang , Alqhatani Abdulmajeed , Asiri Fatima , Salwana Ely 
Published: October 2023

AbstractOnline shopping has become an essential part of modern life, with food delivery being one of the most popular services. In this study, we investigate the factors influencing customers' preferences in online food ordering, such as easy payment, customization, and fast delivery. Analysing customer ratings and reviews is crucial in ensuring the quality of food services and promoting a healthy lifestyle. However, the trustworthiness of online reviews remains a challenge. Based on their rating, new customers can get help from online shoppers for their preferences or demands. Data are collected from customer reviews through online platforms to improve food service quality in online shopping. This work aims to predict the preferences of customers in online shopping based on optimized feature extraction using Principal Component Analysis with a Social Spider Optimization (PCA‐SSO) algorithm. Despite existing algorithms for analysing customer preferences, most may have inaccurate predictions or take time to analyse data. To overcome these challenges, this model of PCA‐SSO is proposed to predict customers' more accurate online shopping preferences. This model provides valuable implications for online shopping owners regarding customer satisfaction. Compared to the accuracy rates of KNN (78.22%), LDA (83.16%), and PCA (88.56%) algorithms, our proposed algorithm of PCA‐SSO achieved a higher accuracy of 93.54%.
Development of genome‐wide association studies on childhood obesity and its indicators: A scoping review and enrichment analysis
Authors: Zhou Feixiang , Tian Gang , Cui Yiran , He Simin , Yan Yan 
Published: October 2023

SummaryBackgroundThe progress of genome‐wide association studies (GWAS) in childhood obesity and its indicators is challenging and there are differences in genetic studies in children and adults.ObjectiveTo illustrate the history of the development of GWAS in childhood obesity and its indicators and summarize the GWAS loci.MethodsPubMed, Web of Science, Embase and GWAS Catalog databases were systematically searched from 1 January 2005 to 19 October 2022 for literature related to GWAS of childhood BMI, body fatness and obesity. The nearest genes were used as positional genes to perform gene set analyses including the enrichment of pathways, tissues and diseases.ResultsTwenty articles published between 2007 and 2021 were included in this scoping review, which identified 116 SNPs reaching genome‐wide significance with childhood BMI (n = 50), body fatness (n = 31) and obesity (n = 35). The study populations were European in 16 studies, non‐European in three studies (1 East Asian; 1 American; 1 Mexican) and trans‐ancestry in one study. Several enriched pathways, tissues and diseases were identified through enrichment analysis of genes associated with childhood obesity and its indicators.ConclusionsThe innovations in tools and methods enable GWAS to better explore the genetic characteristics of obesity in children and adolescents. However, the number of GWAS in American, Asian and African populations is limited compared to the European population.