bluuebunny/crossref_metadata_2025_split huggingface dataset:
Widespread occurrence of Tilapia parvovirus in farmed Nile tilapia Oreochromis niloticus from India
Authors: Rajendran Kooloth Valappil , Sood Neeraj , Rao B. Madhusudhana , Valsalam Anisha , Bedekar Megha K. , Jeena Kezhedath , Pradhan Pravata Kumar , Paria Anutosh , Swaminathan Thangaraj Raja , Verma Dev Kumar , Sood Naresh Kumar 
Published: October 2023

AbstractTilapia parvovirus (TiPV) has been associated with heavy mortalities in tilapia as a single infection or in co‐infection with Tilapia lake virus (TiLV). In this study, TiPV was detected in farmed Nile tilapia, Oreochromis niloticus, from two geographical regions of India, Maharashtra and Uttar Pradesh. TiPV‐specific polymerase chain reaction (PCR) reported earlier was used in the screening. Tilapia collected from Maharashtra showed characteristic clinical signs, and TiPV was detected along with TiLV and/or Aeromonas spp. However, fish from Uttar Pradesh were apparently healthy and only TiPV could be detected in these samples. A high prevalence of TiPV was recorded from both the geographical locations, Maharashtra and Uttar Pradesh (59.6% and 95.0% respectively). The virus could be detected in tissues such as the spleen, liver, kidney, brain and mucus. The spleen appeared to be the best tissue for detecting TiPV in apparently healthy tilapia. The presence of TiPV was further confirmed through sequencing the PCR products, isolation of the virus in the cell line and electron microscopy. Sequences of the NS1 gene of the two TiPV isolates showed similarity to the earlier reported TiPV isolates. The virus could be successfully propagated in O. niloticus Liver (OnL) cell line, and cytopathic effect was observed as early as 3 days post‐infection. Furthermore, the presence of non‐enveloped icosahedral to round virus particles measuring about 26–35 nm could be demonstrated in the cytoplasm and nucleus of infected OnL cells in transmission electron microscopy. With this confirmation of the presence of the virus, India is the third country to report TiPV after China and Thailand. The detection of TiPV in co‐infection cases with TiLV and in apparently healthy Nile tilapia suggests its wide distribution and potential synergistic effect in co‐infection cases. Therefore, this emerging virus needs holistic attention to understand its virulence, host‐specificity and epidemiological risk factors.
Machine learning approaches for estimating apricot drying characteristics in various advanced and conventional dryers
Authors: Kaveh Mohammad , Çetin Necati , Khalife Esmail , Abbaspour‐Gilandeh Yousef , Sabouri Maryam , Sharifian Faroogh 
Published: October 2023

AbstractDrying plays a crucial role in preserving the quality of agricultural products. Nevertheless, suboptimal conditions in drying systems have an adverse effect on drying characteristics and energy efficiency. Machine learning approaches are innovative and reliable that have been successfully used to solve such challenges and achieve optimization in drying processes. In this study, five machine learning approaches (multilayer perceptron [MLP], gaussian processes [GP], support vector regression [SVR], k‐nearest neighbors [kN], and random forest [RF]) were used to estimate moisture content and moisture ratio of apricot in five various dryers (convective [CV], microwave [MW], infrared [IR], microwave‐convective [MW‐CV], and infrared‐convective [IR‐CV]). Also, the values of specific energy consumption (SEC) and effective moisture diffusivity (Deff) were calculated in these dryers. Accordingly, the best result of the Deff (3.14 × 10−10 m2/s) and the minimum value of the drying time (130 min) and SEC (18.67 MJ/kg) were obtained using MW‐CV hybrid dryer. While the lowest values of Deff (2.09 × 10−11 m2/s) and highest drying time (18.5 h) and SEC (209.34 MJ/kg) were detected in CV dryer at 50°C. The best correlation coefficients (R) for the estimation of moisture content were gained using RF technique for k‐fold cross validation and train‐test split with the values of 0.9908 and 0.9912, respectively. Moreover, moisture ratio results showed that the MLP achieved the highest R value over 0.9985 for both validation methodologies. In the discrimination of the drying methods, the MLP had the greatest accuracy as 82.00% and 86.00% for k‐fold cross validation and train‐test split, respectively. The results showed that the RF and ML models could potentially be used for estimation and discrimination for drying applications.Practical ApplicationsRecently, there has been an increased interest in healthy food choices such as foodstuffs, snacks, and dried products. This trend has captured the attention of both dietitians and conscious consumers. Apricots are a prime example of a valuable dried product that can be dry in various conditions. Machine learning techniques can be used for rapid and non‐destructive determination of drying characteristics and such techniques yield objective and accurate results. Present findings revealed that texture machine learning models could be used as an effective and reliable discrimination tool for dried products.
Nature‐based Solutions for sustainable flood management in East Africa
Authors: Long'or Lokidor Pauline , Taka Miho , Lashford Craig , Charlesworth Susanne 
Published: October 2023

AbstractAfrica's population is expected to triple by 2050, owing to rapid urbanisation and overall demographic trends. The combined pressures of urbanisation and climate change impact the ecosystem and the services it provides. As a result, additional dangers such as increased flooding, and environmental disruption have risen. Therefore, devising adaptive solutions to mitigate flood risk impacts while also building community resilience is needed. Evidence suggests that Nature‐based Solutions (NbS) can potentially alleviate floods and mitigate climate change impacts while also delivering other societal benefits. Despite rising NbS popularity following its recognition in the last decade, studies on its recognition in Africa remain limited. For this reason, this paper reviewed NbS studies conducted in East Africa (EA) to evaluate opportunities and barriers surrounding NbS adoption in EA. Academic literature published from January 2012 to May 2022 was reviewed using a comprehensive search of the SCOPUS database. Results show 14 papers have been published during the period, with the majority being post‐2020. In addition, the majority of the articles focused on cities and peri‐urban settlements, while public awareness, clear guidelines on performance monitoring, stakeholder inclusion, and diverse demonstration projects were highlighted as potential success factors for the adoption of NbS in EA.
Unravelling the link between physical activity and peer social connectedness in young people with intellectual disabilities: a systematic review of quantitative studies
Authors: Maenhout L. , Melville C. A. 
Published: October 2023

AbstractBackgroundThere is limited understanding of the context surrounding physical activity (PA) of young people with intellectual disabilities (ID), which has an impact on the development of PA promotion programmes. Peer social connectedness seems to be a vital correlate to focus on, but has not been included in current studies examining the correlates and determinants of PA levels of young people with ID. This study aims to synthesise the evidence on (1) the social constructs researchers have used to conceptualise peer social connectedness in a PA context among young people with ID, (2) the measurement tools that have been used and (3) the relationship between PA and peer social connectedness in young people with ID.MethodsThe review was conducted in accordance with the Preferred Reporting Items for Systematic Reviews and Meta‐Analyses guidelines. Ovid MEDLINE, Ovid Embase, Web of Science, ERIC, CINAHL and PsycINFO were searched from 1 January 1996 up to, and including, July 2023 to identify English‐language studies, which examined associations between PA and peer social connectedness in adolescents and young adults (13–24 years) with ID. Study quality was assessed using the Standard Quality Assessment Criteria for Evaluating Primary Research Papers from a Variety of Fields.ResultsThirteen studies met the inclusion criteria and were included in the review. Ten peer social connectedness constructs and 18 measurement instruments were identified. Studies were predominantly focused on Special Olympics participants and unified activity formats. Participation in PA can increase social connectedness, but there is a lack of studies examining whether PA can also be increased by focusing on peer social connectedness in young people with ID.ConclusionsResults show that peer social connectedness is recognised as relevant to researchers developing and testing PA programmes for young people with ID.
Married women's response to spousal pornography use: A grounded theory
Authors: Crawford Misha D. , Butler Mark H. , Marks Loren D. , Leavitt Chelom J. 
Published: October 2023

AbstractEmpirical research suggests that married women may more commonly experience spousal pornography use as a relational attachment threat and are more likely to experience negative relational outcomes such as distress and loss of trust. The purpose of this study was to develop a grounded theory of married women's response to the discovery or disclosure of spousal pornography use. This study included the experiences of 30 married women who reported spousal pornography use as a threat to relational attachment, who chose to remain with their spouse, and who reported evidence of individual and relational healing thereafter. The research question, “How do married women describe the experience of learning of their spouse's pornography use and the individual and relationship sequelae that follow?” was explored using grounded theory methods to analyze deidentified blogpost accounts emphasizing response to a spouse's pornography use. The results describe a process model highlighting three interrelated informant categories—emotional response, mental response, and physical response—and one resultant category—behavioral response. Implications include (a) the importance of open communication regarding pornography use within relationships, (b) the necessity for individual and relational healing following betrayal trauma, and (c) the role of therapeutic intervention in shaping adaptive healing processes.
The buccal frenum: Trends in diagnosis and indications for treatment of buccal‐ties among 466 healthcare professionals
Authors: Baxter Richard , Merkel‐Walsh Robyn , Lahey Lisa , Knutsen Chad , Zaghi Soroush 
Published: October 2023

AbstractBackgroundThe buccal frenum is connective tissue that adheres the mucosa of the cheek to the alveolar process. When restricted, this condition is commonly known as a buccal‐ or cheek‐tie. Restrictive buccal frena are often treated during tongue‐ and lip‐tie procedures, yet widely accepted classification, diagnostic and treatment guidelines are lacking.ObjectiveProvide a scoping review on the evaluation and management of buccal‐ties, including diagnosis, classification, symptoms and treatment, by surveying healthcare providers with experience evaluating and managing oral restrictions.MethodsLiterature review and IRB‐approved survey to assess practice patterns among healthcare providers identified from online directories of tongue‐tie release providers and associated allied health professionals.ResultsA multidisciplinary group of 466 providers responded. About 87% indicated that they assess buccal restrictions. Evaluation methods included finger sweep (89.1%), visual inspection (76.4%), tissue blanching (66.5%) and functional assessment (53.4%). Around 94% of providers reported that objective and subjective findings are both needed for diagnosis and that an estimated 5%–10% of infants may be affected. About 70% of providers release buccal‐ties (if needed) simultaneously with tongue‐ties, and 76.8% recommend post‐operative stretches as necessary for optimal healing. Respondents indicated a need for further research, evidence‐based assessments, a classification system and treatment protocols.ConclusionEvaluating a buccal frenum to diagnose a symptomatic buccal‐tie relies upon visual inspection, palpation and assessment of oral function. Survey data and clinical experience are summarized to review classification systems, diagnostic/evaluation criteria and treatment recommendations as a foundational cornerstone for future works to build upon.
Glucose upregulates amphiregulin in oral dysplastic keratinocytes: A potential role in diabetes‐associated oral carcinogenesis
Authors: Ma Tao , Montaner Silvia , Schneider Abraham 
Published: October 2023

AbstractBackgroundCompelling evidence implicates diabetes‐associated hyperglycemia as a promoter of tumor progression in oral potentially malignant disorders (OPMD). Yet, information on hyperglycemia‐induced cell signaling networks in oral oncology remains limited. Our group recently reported that glucose‐rich conditions significantly enhance oral dysplastic keratinocyte viability and migration through epidermal growth factor receptor (EGFR) activation, a pathway strongly linked to oral carcinogenesis. Here, we investigated the basal metabolic phenotype in these cells and whether specific glucose‐responsive EGFR ligands mediate these responses.MethodsCell energy phenotype and lactate concentration were evaluated via commercially available assays. EGFR ligands in response to normal (5 mM) or high (20 mM) glucose were analyzed by quantitative real‐time PCR, ELISA, and western blotting. Cell viability and migration assays were performed in the presence of pharmacological inhibitors or RNA interference.ResultsWhen compared to normal keratinocytes, basal glycolysis in oral dysplastic keratinocytes was significantly elevated. In highly glycolytic cells, high glucose‐activated EGFR increasing viability and migration. Notably, we identified amphiregulin (AREG) as the predominant glucose‐induced EGFR ligand. Indeed, enhanced cell migration in response to high glucose was blunted by EGFR inhibitor cetuximab and AREG siRNA. Conversely, AREG treatment under normal glucose conditions significantly increased cell viability, migration, lactate levels, and expression of glycolytic marker pyruvate kinase M2.ConclusionThese novel findings point to AREG as a potential high glucose‐induced EGFR activating ligand in highly glycolytic oral dysplastic keratinocytes. Future studies are warranted to gain more insight into the role of AREG in hyperglycemia‐associated OPMD tumor progression.
Being open, feeling safe and getting creative: The role of team mean openness to experience in the emergence of team psychological safety and team creativity
Authors: Sacramento Claudia , Lyubovnikova Joanne , Martinaityte Ieva , Gomes Catarina , Curral Luis , Juhasz‐Wrench Andrea 
Published: October 2023

AbstractAlthough the effects of openness to experience (OTE) on individual creativity are well‐established, research on how such effects unfold in a team context is scarce. Drawing on theories of group norms and uncertainty reduction, we argue that team mean OTE leads to a climate of team psychological safety which, in turn, facilitates team creativity. We test our hypothesis over three independent studies, the first comprising 35 business student project teams, the second based on 28 professional teams from the automotive industry, both conducted in the United Kingdom, and the third comprising 24 healthcare teams in Portugal. As predicted, across all three studies, team mean OTE was positively associated with team creativity via the affective emergent state of team psychological safety. Furthermore, the mediating role of team psychological safety remained significant even when accounting for team OTE variance, alternative motivational and cognitive emergent states, namely team promotion focus (studies 1 and 2) and team exploration climate (study 3), as well as empowering leadership (study 3). Finally, in study 3, we examined the differential impact of the two major facets of OTE, intellect, and openness, and found that intellect, but not openness, was responsible for driving the indirect effects. Further analysis did not support alternative perspectives concerning team OTE variance or the interaction between mean and variance. Our findings not only contribute to theoretical understanding regarding the relationship between team personality composition, specifically OTE, and team creativity but also provide much‐needed insight into how such effects unfold. We delineate several practical implications for team design and development.
The osteogenic effects of sappanchalcone in vitro and in vivo
Authors: Zheng Xiaodan , Chen Jingqiu , Liu Juan , Shi Xiaoying , Li Gang , Shi Qimeng , Zhang Jun , Li Yanhong 
Published: October 2023

AbstractBackground and ObjectivesThe utilization of natural products to enhance the function of periodontal ligament cells (PDLCs) has emerged as a popular area of research. Recent investigations have demonstrated that sappanchalcone (SC) possesses pharmacological properties such as anti‐inflammatory and osteoprotective effects. This study aims to explore the impact of SC on the in vivo and in vitro osteogenic differentiation ability of PDLCs.MaterialsCell proliferation was quantified using the CCK‐8 assay, while gene expression levels were assessed through qRT–PCR analysis. Osteoblast differentiation capacity was evaluated by employing Alizarin red staining (ARS), alkaline phosphatase (ALP) staining and western blot (WB) analysis. A rat model of periodontitis was established utilizing the tether‐wire method. Micro‐CT imaging and hematoxylin and eosin (HE) staining were employed to evaluate alveolar bone resorption. Masson's trichrome staining was utilized to observe fiber alignment, whereas immunohistochemistry (IHC) techniques were applied for detecting osteogenic and inflammatory factors.ResultsThe results from the CCK‐8 assay indicate no observed cytotoxicity for concentrations of 1, 5, or 10 nM for SC treatment (p < .05), while qRT–PCR analysis demonstrates a significant decrease in inflammatory factors such as MMP‐1 and IL‐6 with treatment by SC (p < .05). Additionally, western blotting reveals an increase in protein expression levels of Runx2 and OPN within PDLCs treated with SC compared to control groups (p < .05), which is further supported by ARS and ALP staining indicating an increase in mineralized nodules formation along with elevated ALP content within these cells following treatment with this compound (p < .05). Finally, both HE staining as well as micro‐CT imaging suggest potential benefits associated with using this compound including slowing alveolar bone resorption while simultaneously promoting junctional epithelium proliferation.ConclusionsOur in vitro and in vivo findings suggest that SC can effectively enhance the inflammatory response of PDLCs and promote their osteogenic differentiation ability under inflammatory conditions, indicating its potential as a promising therapeutic agent for improving periodontal inflammation and bone formation.
Understanding the impacts of rural hospital closures: A scoping review
Authors: Mullens Cody Lendon , Hernandez J. Andres , Murthy Jeevan , Hendren Steph , Zahnd Whitney E. , Ibrahim Andrew M. , Scott John W. 
Published: October 2023

AbstractPurposeRural hospitals are closing at unprecedented rates, with hundreds more at risk of closure in the coming 2 years. Multiple federal policies are being developed and implemented without a salient understanding of the emerging literature evaluating rural hospital closures and its impacts. We conducted a scoping review to understand the impacts of rural hospital closure to inform ongoing policy debates and research.MethodsA comprehensive search strategy was devised by library faculty to collate publications using the PRISMA extension for scoping reviews. Two coauthors then independently performed title and abstract screening, full text review, and study extraction.FindingsWe identified 5054 unique citations and assessed 236 full texts for possible inclusion in our narrative synthesis of the literature on the impacts of rural hospital closure. Twenty total original studies were included in our narrative synthesis. Key domains of adverse impacts related to rural hospital closure included emergency medical service transport, local economies, availability and utilization of emergency care and hospital services, availability of outpatient services, changes in quality of care, and workforce and community members. However, significant heterogeneity existed within these findings.ConclusionsGiven the significant heterogeneity within our findings across multiple domains of impact, we advocate for a tailored approach to mitigating the impacts of rural hospital closures for policymakers. We also discuss crucial knowledge gaps in the evidence base—especially with respect to quality measures beyond mortality. The synthesis of these findings will permit policymakers and researchers to understand, and mitigate, the harms of rural hospital closure.
Infant and young child feeding indicators are positively associated with length and family care indicators in the children of the Women First trial participants
Authors: Long Julie M. , Gatica‐Domínguez Giovanna , Westcott Jamie E. , Taren Douglas , Tejeda Gabriela , Diba Tshilenge S. , Mastiholi Shivanand C. , Khan Umber S. , Garcés Ana , Figueroa Lester , Lokangaka Adrien , Goudar Shivaprasad S. , Aziz Ali Sumera , Hambidge K. Michael , Krebs Nancy F. ,   the Women First Preconception Maternal Nutrition Study Group
Published: October 2023

AbstractThis research describes the proportion of children in four low‐ and middle‐income countries with adequate dietary practices at 6, 12, 18 and 24 months of age and how these practices changed over time using the World Health Organisation and UNICEF's infant young child feeding (IYCF) indicators. The associations between the IYCF indicators and anthropometric z‐scores from 6 to 24 months, and between the IYCF indicators and the family care indicators (FCIs) at 24 months are described. This was a longitudinal study of offspring from participants in the Women First Preconception Maternal Nutrition Trial conducted in Sud‐Ubangi, Democratic Republic of Congo; Chimaltenango, Guatemala; Belagavi, North Karnataka, India; and Thatta, Sindh Province, Pakistan. The frequency of the minimum dietary diversity (MDD), minimum meal frequency (MMF), and minimum adequate diet (MAD) increased between 6 and 24 months, but even at 24 months MAD remained below 50% at all sites. MDD (β = 0.12; 95% CI = 0.04−0.22) and MMF (β = 0.10; 95% CI = 0.03−0.17) were positively associated with length‐for‐age z‐score at 24 months. All IYCF indicators were positively associated with mean total FCI score: MDD (proportion ratio [PR] = 1.04; 95% CI = 1.02−1.07), MMF (PR = 1.02; 95% CI = 1.01−1.04), MAD (PR = 1.05; 95% CI = 1.02−1.08). Although there are multiple barriers to young children having an adequate diet, our results support a positive association between familial interactions and improved IYCF feeding practices.