bluuebunny/crossref_metadata_2025_split huggingface dataset:
Effect of Cigarette Smoking on Clozapine Dose and on Plasma Clozapine and N-Desmethylclozapine (Norclozapine) Concentrations in Clinical Practice
Authors: Flanagan Robert James , Hunter Samora , Obee Stephen John 
Published: November 2023

Abstract

Background
Cigarette smoking enhances plasma clozapine clearance and thus affects the clozapine dose requirement.

Methods
We compared clozapine daily dose and plasma clozapine and N-desmethylclozapine (norclozapine) concentrations in male and female smokers and nonsmokers in samples submitted for clozapine therapeutic drug monitoring (1996–2017).

Results
There were 105,316/60,792 and 34,290/31,309 samples with dose information from male and female smokers/nonsmokers, respectively. There was information on the number of cigarettes smoked daily for 12,842 samples (8409 patients) and 3948 samples (2753 patients) from men and women, respectively. Of these, 574 and 253 samples were from men and women, respectively, who reported smoking 1–9 cigarettes daily.
In both sexes, the median clozapine doses in the nonsmokers were 75%–80% of those in the smokers, but the median plasma clozapine and norclozapine concentrations were 136% higher. The effect of smoking on the dose and on median plasma clozapine and norclozapine concentrations seemed maximal after 2–3, perhaps fewer, cigarettes daily in males. In females, the effect of smoking seemed to be near maximal after some 4–5 cigarettes per day.

Implications
The optimum target range for predose plasma clozapine may be different in smokers (0.35–0.45 mg L−1) as opposed to nonsmokers (0.50–0.60 mg L−1). That changes in clozapine clearance are likely near maximal with cigarette smoking as low as 2–3 d−1 in males, perhaps slightly more in females, emphasizes that covert or passive smoking may be an important factor in seemingly random changes in plasma clozapine concentration at constant dose.
Gender perspective in psoriasis: a scoping review and proposal of strategies for improved clinical practice by European dermatologists
Authors: Gonzalez-Cantero Alvaro , Constantin María Magdalena , Dattola Annunziata , Hillary Tom , Kleyn Elise , Magnolo Nina 
Published: November 2023

Background:
The prevalence of psoriasis is similar between men and women; however, evidence exists of sex- and gender-related differences in disease expression, impact, coping, and needs of patients with psoriasis. These differences are essential and should be considered in clinical practice and research.

Objective:
To compile available evidence on sex- and gender-related differences in psoriasis, identify the most critical gaps in clinical practice and research, and use it to propose strategies for improved clinical practice.

Methods:
Six European dermatologists selected the topics to consider according to their relevance in the dermatology setting with the support of methodologists. Evidence on sex- and gender-related differences was obtained by a scoping review based on search strategies in Medline and Cochrane Library from inception to October 2021 using the following terms: arthritis, psoriatic, psoriasis, gender, and sex. The panel discussed the results and proposed strategies by consensus.

Results:
The scoping review identified broad themes: (1) clinical expression, (2) severity and patient-reported outcomes, (3) psychosocial impact, (4) access to treatments and propensity to treat, (5) comorbidities, and (6) treatment effect. The strategies are based on these broad themes.

Limitations:
No risk of bias assessment was done due to the scoping nature of the review.

Conclusion:
This review offers insights into gender differences in psoriasis, providing a foundation for improving clinical practice and patient outcomes.
Climate crisis and nephrology: a review of climate change's impact on nephrology and how to combat it
Authors: Dupuis Leonie , Varshney Aarushi , Patel Jason , Joshi Shivam 
Published: November 2023

Climate change is worsening with tangible effects on our healthcare system. This review aims to examine the repercussions of the climate change on nephrology and explore potential strategies to mitigate its impact. This review examines dialysis's environmental impact, resource recycling methods, and plant-based diets for kidney health. Recent research highlights the advantages of plant-based diets in managing and preventing chronic kidney disease (CKD) and its complications. Integrating these practices can significantly lessen the environmental impact of nephrology.

Purpose of review
The aim of this study is to discuss the bidirectional relationship of climate change and kidney disease and the impact of nephrology on climate change and to discuss potential solutions.

Recent findings
Each dialysis session consumes significant amounts of resource; reusing them will aid the environment. Plant-based diets slow renal disease and have a lower carbon footprint, making them ecologically friendly.

Summary
Climate change is a growing threat to population health and healthcare. Rising temperatures raise the risk of kidney problems. Dialysis treatments also impact the environment through its high resource requirements while generating high volumes of waste and greenhouse gases. Opportunities exist to reduce the environmental impact of dialysis treatments. Plant-based diets serve to benefit both kidney disease and the environment.
Efficacy and Safety of Rimegepant for Migraine Patients: A Meta-analysis of Randomized Controlled Studies
Authors: Yang Chao , Zhang Yue 
Published: November 2023

Objectives
Rimegepant may have some potential in treating migraine, and this meta-analysis aims to study the efficacy and safety of rimegepant for migraine patients.

Methods
We have searched several databases including PubMed, Embase, Web of Science, EBSCO, and Cochrane Library databases and selected the randomized controlled trials comparing the efficacy of rimegepant versus placebo for migraine patients. This meta-analysis was conducted using the random- or fixed-effect model based on the heterogeneity.

Results
Three randomized controlled trials were included in this meta-analysis. Compared with placebo in migraine patients, rimegepant treatment was associated with substantially improved freedom from pain at 2 hours (odds ratio [OR], 2.10; 95% confidence interval [CI], 1.69–2.59; P < 0.00001), pain relief at 2 hours (OR, 1.93; 95% CI, 1.65 to 2.25; P < 0.00001), freedom from the most bothersome symptom at 2 hours (OR, 1.61; 95% CI, 1.35–1.91; P < 0.00001), ability to function normally at 2 hours (OR, 1.69; 95% CI, 1.42–2.01; P < 0.00001), sustained freedom from pain at 24 hours (OR, 2.88; 95% CI, 1.74–4.78; P < 0.0001), sustained pain relief at 24 hours (OR, 2.31; 95% CI, 1.96–2.72; P < 0.00001), and no rescue medication (OR, 2.42; 95% CI, 2.02–2.90; P < 0.00001) but showed no obvious impact on adverse events (OR, 1.27; 95% CI, 1.01–1.60; P = 0.04).

Conclusions
Rimegepant may be effective and safe for the treatment of migraine patients.
Comparison of Large Language Models in Answering Immuno-Oncology Questions: A Cross-Sectional Study
Authors: Iannantuono Giovanni Maria , Bracken-Clarke Dara , Karzai Fatima , Choo-Wosoba Hyoyoung , Gulley James L. , Floudas Charalampos S. 
Published: November 2023

ABSTRACTBackgroundThe capability of large language models (LLMs) to understand and generate human-readable text has prompted the investigation of their potential as educational and management tools for cancer patients and healthcare providers.Materials and MethodsWe conducted a cross-sectional study aimed at evaluating the ability of ChatGPT-4, ChatGPT-3.5, and Google Bard to answer questions related to four domains of immuno-oncology (Mechanisms, Indications, Toxicities, and Prognosis). We generated 60 open-ended questions (15 for each section). Questions were manually submitted to LLMs, and responses were collected on June 30th, 2023. Two reviewers evaluated the answers independently.ResultsChatGPT-4 and ChatGPT-3.5 answered all questions, whereas Google Bard answered only 53.3% (p <0.0001). The number of questions with reproducible answers was higher for ChatGPT-4 (95%) and ChatGPT3.5 (88.3%) than for Google Bard (50%) (p <0.0001). In terms of accuracy, the number of answers deemed fully correct were 75.4%, 58.5%, and 43.8% for ChatGPT-4, ChatGPT-3.5, and Google Bard, respectively (p = 0.03). Furthermore, the number of responses deemed highly relevant was 71.9%, 77.4%, and 43.8% for ChatGPT-4, ChatGPT-3.5, and Google Bard, respectively (p = 0.04). Regarding readability, the number of highly readable was higher for ChatGPT-4 and ChatGPT-3.5 (98.1%) and (100%) compared to Google Bard (87.5%) (p = 0.02).ConclusionChatGPT-4 and ChatGPT-3.5 are potentially powerful tools in immuno-oncology, whereas Google Bard demonstrated relatively poorer performance. However, the risk of inaccuracy or incompleteness in the responses was evident in all three LLMs, highlighting the importance of expert-driven verification of the outputs returned by these technologies.IMPLICATIONS FOR PRACTICESeveral studies have recently evaluated whether large language models may be feasible tools for providing educational and management information for cancer patients and healthcare providers. In this cross-sectional study, we assessed the ability of ChatGPT-4, ChatGPT-3.5, and Google Bard to answer questions related to immuno-oncology. ChatGPT-4 and ChatGPT-3.5 returned a higher proportion of responses, which were more accurate and comprehensive, than those returned by Google Bard, yielding highly reproducible and readable outputs. These data support ChatGPT-4 and ChatGPT-3.5 as powerful tools in providing information on immuno-oncology; however, accuracy remains a concern, with expert assessment of the output still indicated.
Interplay between harvesting, planting density and ripening time affects coffee leaf rust dispersal and infection
Authors: Van Cauwelaert Emilio Mora , Li Kevin , Hajian-Forooshani Zachary , Vandermeer John , Benítez Mariana 
Published: November 2023

ABSTRACTThe relationship between the spatial structure of hosts and the individual movement of vectors is central to developing a comprehensive representation of pathogen dynamics. Here we focus on the dynamics of coffee leaf rust (CLR; Hemileia vastatrix), which is one of the principal coffee diseases around the globe. This fungus disperses between plants or regions through direct contact, water splash, or local turbulent wind conditions. Some studies have proposed that coffee harvesters can also bear CLR during harvesting. However, it is not clear how relevant these movements are for CLR dispersal and plot-level infection in plots with different planting densities. Besides, there are bidirectional interactions between the plantation characteristics (e.g. planting density and ripening synchronicity) and the movement of harvesters that might modify their dispersal potential. Overall, there is a lack of mechanistic models to represent these interactions. Here we present a computational model to explore the role of coffee ripening synchronicity in reproducing the different movement trajectories observed in the field. We then evaluate how these harvesting trajectories modify rust dispersal and change CLR infection in plots with increasing planting densities and a constant contact-mediated rust dispersal mechanism. For both synchronization scenarios, the distribution of step lengths is positively skewed. Interplant asynchronous ripening and scarcity of trees with berries generate trajectories with medium to long steps contrary to scenarios with synchronous ripening and without scarcity. The harvest dispersal significantly increases coffee plot infection (up to 15%) compared to scenarios where only local mechanisms for CLR dispersal are present. This effect is maximal for trajectories with medium to long steps from the asynchronous scenario and in plantations with medium planting densities. In particular, medium-sized steps are more likely to create new foci and networks of contact-mediated infected plants. The interaction between the proportion and the size of infected networks results in a nonlinear behavior of rust increase due to harvest. Our results aim to spur discussion on practices that could reduce the impact of harvesting and specific trajectories, in scenarios where one can benefit from asynchronous maturation of berries and shaded plantations. Some examples of practices include reducing the medium to long-distance movements during the same day, for instance, by avoiding harvesting at the end of the harvest season when trees ripening asynchronicity and CLR levels are higher.
Poland–USA sectoral trade balances: regime shifts and the nonlinear impact of currency fluctuations
Authors: Pruchnicka-Grabias Izabela , Piekunko-Mantiuk Iwona , Hegerty Scott W. 
Published: November 2023

PurposeThe Polish economy has undergone major challenges and changes over the past few decades. The country's trade flows, in particular, have become more firmly tied to the country’s Western neighbors as they have grown in volume. This study examines Poland's trade balances in ten Standard International Trade Classification (SITC) sectors versus the United States of America, first testing for and isolating structural breaks in each time series. These breaks are then included in a set of the cointegration models to examine their macroeconomic determinants.Design/methodology/approachLinear and nonlinear and nonlinear autoregressive distributed lag models, both with and without dummies corresponding to structural breaks, are estimated.FindingsOne key finding is that incorporating these breaks reduces the significance of the real exchange rate in the model, supporting the hypothesis that this variable already incorporates important information. It also results in weaker evidence for cointegration of all variables in certain sectors.Research limitations/implicationsThis study looks only at one pair of countries, without any third-country effects.Originality/valueAn important country pair's trade relations is examined; in addition, the real exchange rate is shown to incorporate economic information that results in structural changes in the economy. The paper extends the existing literature by conducting an analysis of Poland's trade balances with the USA, which have not been studied in such a context so far. A strong point is a broad methodology that lets compare the results the authors obtained with different kinds of models, both linear and nonlinear ones, with and without structural breaks.
Effects of educational mismatch on wages across industry and occupations: sectoral comparison
Authors: Lasso-Dela-Vega Elena , Sánchez-Ollero José Luis , García-Pozo Alejandro 
Published: November 2023

PurposeThis study conducts a comparative analysis of the impact of educational mismatch on Spanish wages. This paper aims to focus on the industrial, construction and service sectors at three levels of disaggregation: sector, occupation and gender.Design/methodology/approachThe over-education, required education and under-education (ORU model), was applied to data from the 2018 Spanish Wages Structure Survey conducted by the Spanish National Statistics Institute.FindingsThe industrial sector is the one that best manages over-education by offering the highest returns to each year of over-education. It is also the sector that most values the education of women, particularly those in highly qualified positions.Originality/valueThis study compares the wage effects of educational mismatch in the service, industry and construction sectors. Previous literature has ignored the latter sectors in this field of study, but the results of the present study show that the industrial sectors significantly value and remunerates worker education. Therefore, it may be worthy to focus certain economic and social policies on this sector, to contribute to reducing gender wage gaps and gender employment discrimination in the economy.
Efficiency and performance of Islamic banks amid COVID-19
Authors: Nguyen Lan-Huong , Le Tu D.Q. , Ngo Thanh 
Published: November 2023

Purpose
This paper aims to investigate the efficiency and performance of the Islamic banking industry amid the COVID-19 pandemic.

Design/methodology/approach
The authors used a two-stage data envelopment analysis to first estimate the efficiency of 78 Islamic banks (IBs) across 15 countries for the 2005–2020 period (a total of 782 bank-year observations) and then to examine their determinants, including the COVID-19 pandemic.

Findings
The authors found that the Islamic banking industry performed at a moderate level during the 2005–2020 period, providing evidence that IBs are resilient to the financial shocks created by COVID-19. The authors also found that bank-level characteristics (such as bank size) and country-level characteristics (such as inflation) can contribute to the bank’s operational efficiency.

Research limitations/implications
The results of this study suggested that banking management and government macroeconomic policy, especially in terms of precautions and continuous support, are important for IBs to improve their performance.

Originality/value
To the best of the authors’ knowledge, this is the first study to examine the efficiency and performance of IBs amid COVID-19.
Entrepreneurial marketing strategy in craft-based businesses in an emerging market: a qualitative interpretivist approach
Authors: Saiyed Abrar Ali , Shaikh Ateeque , Gupta Suruchika 
Published: November 2023

Purpose
The primary aim of this study is to gain insight into the entrepreneurial marketing strategy (EMS) decisions made by microenterprises in the craft sector and draw comparisons between the marketing strategy formulation and implementation of conventional businesses and those of craft-based microenterprises with a specific focus on the context of emerging markets, particularly India.

Design/methodology/approach
This paper follows a qualitative interpretivist paradigm using a multiple-case methodology approach. It tracks craft-based microenterprises that make furniture or home décor products in India. The study participants were the founders, principal designers, studio managers or craftspersons.

Findings
This study’s findings reveal that craft-based microenterprises implement an EMS that adopts a hybrid form of market orientation strategy. In this approach, the product or creative concept is at the centre of the decision-making, and the customer needs are factored in at a later stage for customisation. These microenterprises prioritise product positioning over segmentation and targeting strategies.

Research limitations/implications
This study tries to understand marketing strategy decision-making processes among craft-based microenterprises in India. Given that study participants came from only two-product-based craft businesses, this limits the generalisability of the findings to similar or related contexts. This study provides a framework and methodology for replication in other contexts and industries to formulate a nuanced understanding of micro, context-specific, craft-based businesses.

Originality/value
This study uses qualitative analysis to understand EMS in craft-based businesses in India. This study contributes to this fledgling stream of literature at the interface of marketing and entrepreneurship to understand entrepreneurial marketing. This study analyses the marketing strategy of craft-based businesses using the framework of Morgan et al. (2019).
Foreign subsidiary performance: social trust–entry fit
Authors: Yu Jie , Yi Changjun , Shen Huiyun 
Published: November 2023

PurposeThis paper aims to study whether the adoption of an entry mode that fits the social trust level contributes to the improvement of foreign subsidiary performance.Design/methodology/approachThe authors used the Probit model, linear regression, strategic fit approach and instrumental variable regression. The sample was made up of 11,095 observations of Chinese multinational enterprises' foreign subsidiaries in 54 countries from 2005 to 2020.FindingsThe results suggest that a host country with a high level of social trust results in fewer difficulties for enterprises in gaining legitimacy, thus foreign subsidiaries are more likely to select the wholly owned entry mode. The results also show that the effect is contingent on the formal institutions of host countries. The results of the mechanism test suggest that social trust influences subsidiaries' entry mode choice by reducing information asymmetry, costs and uncertainty risks. This study further finds that selecting a fit entry mode based on social trust level substantially increases foreign subsidiary performance and this effect is more significant when multinational enterprises (MNEs) are state-owned enterprises (SOEs).Research limitations/implicationsThe main limitation of this paper is its only focus on foreign subsidiaries of Chinese MNEs, which may limit the generalizability of research findings.Originality/valueThis paper responds to the call for conducting more research on informal institutions. Findings highlight the critical role of informal institutions in helping foreign subsidiaries in gaining legitimacy in host countries and the essentialness of selecting a fit entry mode based on the informal institutions of host countries for the development of foreign subsidiaries.
Teaching, research, and service as drivers of academic career success
Authors: Varela Otmar , Premeaux Sonya 
Published: November 2023

Purpose
In response to current initiatives that seek to rebalance the facets of academic jobs, this paper aims to examine the impact of teaching, research and service on objective (e.g. salary) and subjective (i.e. satisfaction) indicators of career success.

Design/methodology/approach
The authors collected data from 182 tenure-track management faculty from public universities in the USA. The selection of participants followed a stratified sample from two traditional segments in higher education, research-intensive and teaching-research balanced institutions. Hierarchical regression analysis was used for testing the study hypotheses.

Findings
Results reveal that research achievements is the only job facet that accounts for objective and subjective indicators of career success across institutions. Outcomes suggest the impact of the initiatives put in place to elevate the role of teaching and service in the life of academics are falling short.

Originality/value
The study provides evidence about the need to adjust policy that seeks to rebalance academic jobs.