bluuebunny/crossref_metadata_2025_split huggingface dataset:
The angiotensin-converting enzyme I/D polymorphism does not impact training-induced adaptations in exercise capacity in patients with stable coronary artery disease
Authors: Sjúrðarson Tórur , Kristiansen Jacobina , Nordsborg Nikolai B. , Gregersen Noomi O. , Lydersen Leivur N. , Grove Erik L. , Kristensen Steen D. , Hvas Anne-Mette , Mohr Magni 
Published: October 2023

AbstractSystematic exercise training effectively improves exercise capacity in patients with coronary artery disease (CAD), but the magnitude of improvements is highly heterogeneous. We investigated whether this heterogeneity in exercise capacity gains is influenced by the insertion/deletion (I/D) polymorphism of the angiotensin-converting enzyme (ACE) gene. Patients with CAD (n = 169) were randomly assigned to 12 weeks of exercise training or standard care, and 142 patients completed the study. The ACE polymorphism was determined for 128 patients (82% males, 67 ± 9 years). Peak oxygen uptake was measured before and after the 12-week intervention. The ACE I/D polymorphism frequency was n = 48 for D/D homozygotes, n = 61 for I/D heterozygotes and n = 19 for I/I homozygotes. Baseline peak oxygen uptake was 23.3 ± 5.0 ml/kg/min in D/D homozygotes, 22.1 ± 5.3 ml/kg/min in I/D heterozygotes and 23.1 ± 6.0 ml/kg/min in I/I homozygotes, with no statistical differences between genotype groups (P = 0.50). The ACE I/D polymorphism frequency in the exercise group was n = 26 for D/D, n = 21 for I/D and n = 12 for I/I. After exercise training, peak oxygen uptake was increased (P < 0.001) in D/D homozygotes by 2.6 ± 1.7 ml/kg/min, in I/D heterozygotes by 2.7 ± 1.9 ml/kg/min, and in I/I homozygotes by 2.1 ± 1.3 ml/kg/min. However, the improvements were similar between genotype groups (time × genotype, P = 0.55). In conclusion, the ACE I/D polymorphism does not affect baseline exercise capacity or exercise capacity gains in response to 12 weeks of high-intensity exercise training in patients with stable CAD.Clinical trial registration: www.clinicaltrials.gov (NCT04268992).
Metabolomic analysis indicated changes in triacylglycerols’ levels as a result of training in Whippet dogs
Authors: Miazga Katarzyna , Kopczyńska Klaudia , Szaluś-Jordanow Olga , Moroz-Fik Agata , Wilczak Jacek , Barszcz Karolina , Cywińska Anna 
Published: October 2023

AbstractRegular physical effort produces metabolic changes manifested as adaptation to exercise and increasing performance. In humans these changes have been characterized at metabolome level as depending on the discipline. However, all sports involve some level of changes in protein, carbohydrate and lipid metabolism. Recently, also performance horses have been subjected to metabolic analyses, but similar studies were lacking in sports dogs. In this study we performed the metabolomic analysis in plasma of Whippet dogs regularly trained and competing in coursing events, and untrained dogs of the same breed, fed with the same diet. We have also compared the hematological and blood biochemical results in these two groups of dogs. Basic blood tests indicated that enzymes related to lipid metabolism (lipase and gamma-glutamyltransferase) differed considerably between the groups. Metabolomic analysis of plasma confirmed the metabolic shift expressed as the differences in triacylglycerols levels between training and non-training dogs, aimed at improving the use of fatty acids as a source of energy during exertion. Surprisingly, other classes of metabolites were only hardly changed when comparing training and non-training Whippets.
Striking efficacy of a vaccine targeting TOP2A for triple-negative breast cancer immunoprevention
Authors: Lee Sang Beom , Pan Jing , Xiong Donghai , Palen Katie , Johnson Bryon , Lubet Ronald A. , Shoemaker Robert H. , Green Jeffrey E. , Fernando Romaine Ingrid , Sei Shizuko , You Ming , Wang Yian 
Published: October 2023

AbstractTriple-negative breast cancer (TNBC) is an aggressive subtype of breast cancer that has a poor prognosis. TOP2A is a key enzyme in DNA replication and is a therapeutic target for breast and other cancers. TOP2A-specific Th1-promoting epitopes with optimal binding affinity to MHC II were identified using a combined scoring system. The multi-peptide TOP2A vaccine elicited a robust immunologic response in immunized mice, as demonstrated by the significant production of Th1 cytokines from immunized animals’ splenocytes stimulated in vitro with TOP2A peptides. Anti-tumor efficacy of the TOP2A vaccine was demonstrated in a syngeneic TNBC mouse model, in which pre-graft preventive vaccination was associated with significantly decreased tumor growth as compared to adjuvant control. In a genetically engineered mouse (GEM) model of TNBC, vaccinated animals demonstrated a significant reduction in tumor incidence and average tumor volume compared to adjuvant control. Finally, we examined TCR sequences in CD4 tumor Infiltrating lymphocytes (TIL) from vaccinated mice and found that the TIL contained TCR sequences specific to the three vaccine peptides. These data indicate that our newly developed multi-peptide TOP2A vaccine is highly immunogenic, elicits TILs with vaccine specific TCRs, and is highly effective in preventing and intercepting TNBC development and progression in vivo.
Atmospheric dynamics and shock waves in RR Lyr
Authors: Gillet D. , Sefyani F. L. , Benhida A. , Mauclaire B. , El Youssoufi D. , de France T. , Benkhaldoun Z. , Lailly P. 
Published: October 2023

Context. Although spectroscopic observations of RR Lyrae stars have been underway for almost a century, the fact that the hydrogen line exhibits three successive emissions in each pulsation cycle is still a very recent discovery.
Aims. The purpose of the present study is to clarify the physical origin of these three emissions and their connection to atmospheric dynamics and to examine the influence of Blazhko modulation on their intensity.
Methods. We used 2437 high-resolution spectra over a total of 81 nights taken by the ELODIE spectrograph (Haute Provence Observatory, France) in the years 1994–1997, rounded out with a 2015 run from Oukaïmeden Observatory (Morocco). We performed a detailed analysis of the line profile variations over the whole pulsation cycle.
Results. Based on the blueshift of the main Hα emission, the velocity of the hypersonic shock front was estimated at between 100 and 150 ± 10 km s−1 (Mach number between 10 and 15). It has been established that the shock velocity increases from the minimum Blazhko to its maximum and afterward, it gradually decreases to the Blazhko minimum to start growing again. This observational result is consistent with the shock model proposed in 2013 to explain the Blazhko effect. The intensity of the Hα emission increases with the shock velocity up to a maximum value around 137 km s−1 and then decreases as the shock velocity increases further. This effect would be the consequence of the increasingly important ionization of the atoms in the radiative shock wake. The second (blueshifted) Hα emission is the consequence of an approximately constant supersonic compression (Mach number between 2 and 3) of the upper atmosphere falling onto the photospheric layers, during 3 to 16% of the pulsation period. Finally, the third Hα emission (P-Cygni profile) would be the consequence of the expansion of the high atmosphere induced by the shock wave during its final weakening.
Orbit determination for the binary Cepheid V1344 Aql
Authors: Cseh B. , Csörnyei G. , Szabados L. , Csák B. , Kovács J. , Kriskovics L. , Pál A. 
Published: October 2023

Context. Binary Cepheids play an important role in the investigation of the calibration of the classical Cepheid period-luminosity relationship. Therefore, a thorough study of individual Cepheids belonging to binary systems is necessary.
Aims. Our aim is to determine the orbit of the binary system V1344 Aql using newly observed and earlier published spectroscopic and photometric data.
Methods. We collected new radial velocity observations using medium resolution (R ≈ 11 000 and R ⪅ 20 000) spectrographs, and we updated the pulsation period of the Cepheid based on available photometric observations using an O − C diagram. Separating the pulsational and orbital radial velocity variations for each observational season (year), we determined the orbital solution for the system using χ2 minimisation.
Results. The updated pulsation period of the Cepheid estimated for the epoch of HJD 2458955.83 is 7.476826 days. We determined orbital elements for the first time in the literature. The orbital period of the system is about 34.6 yr, with an eccentricity of e = 0.22.
Efficient Synthesis of (Z)-4-((Substituted phenylamino)methyl­idene)isoquinoline-1,3(2H,4H)-diones Using the Eschenmoser Coupling Reaction
Authors: Hanusek Jiří , Marek Lukáš , Váňa Jiří , Svoboda Jan , Svobodová Markéta 
Published: October 2023

AbstractA novel synthetic strategy involving the Eschenmoser coupling reaction of 4-bromoisoquinoline-1,3(2H,4H)-diones with substituted thioformanilides, thioacetanilides, and thiobenzanilides gave 18 (Z)-4-((substituted phenylamino)methylidene)isoquinoline-1,3(2H,4H)-diones. The reaction occurs under mild conditions (DMF or MeCN, 25–60 °C) without any base or thiophile and in good yields (43–95%). Furthermore, for the synthesis of starting thioformanilides carrying basic substituents, a new thioacylation protocol was developed that involves a thioacylating agent formed from carbon disulfide and lithium triethylborohydride.
[Pyridine–SO3H]ZnCl3: A Multipurpose Catalyst for A3 Coupling Synthesis of Propargylamines under Mild Conditions
Authors: Moosavi-Zare Ahmad Reza , Rezaei-Gohar Mohammad , Tavasoli Mahsa , Goudarziafshar Hamid 
Published: October 2023

Abstract
N-Sulfopyridin-1-ium monozinc(II) trichloride ([NSPy]ZnCl3) was prepared and used as a multipurpose catalyst for the synthesis of propargylamines by the A3 coupling reaction of aromatic aldehydes, alkynes, and secondary amines under mild conditions. In this reaction, the carbonyl group in the aldehyde was activated by the acidic part in the catalyst, and the C–H activation of phenylacetylene was carried out by zinc.
ESG criteria and the credit risk of corporate bond portfolios
Authors: Höck Andre , Bauckloh Tobias , Dumrose Maurice , Klein Christian 
Published: October 2023

AbstractDemand for sustainable fixed-income investment solutions is surging but there is hardly research on the impact of sustainability on the risk characteristics of fixed-income portfolios. This study examines the impact of sustainability on the credit risk exposure of corporate bond portfolios between 2013 and 2020 by analyzing the returns of sustainable and non-sustainable portfolios using two different asset pricing models and environmental, social, and governance (ESG) ratings from different providers. Controlling for a set of portfolio characteristics, our results show that sustainable portfolios are significantly less exposed to credit risk than their non-sustainable peer portfolios. This finding implies that considering ESG criteria in portfolio management is a suitable means to systematically manage credit risk. Being the first study to investigate the relationship between sustainability and credit risk on a portfolio level, this study contributes to the understanding of the effects of ESG criteria in portfolio management and provides academics and investment professionals with valuable insights.
Design of multi-frequency point, high-isolation switches for micro-channel plate data acquisition
Authors: Yang Yihao , Gou Yongsheng , Yang Yang , Feng Penghui , Wang Bo , Liu Baiyu , Wei Jianan , Tian Jinshou , Zhao Wei 
Published: October 2023

In order to replace the phosphor screen of a proximity-gated x-ray framing camera with a readout circuit using a time-interleaved structure, this paper carries out the design of a high-isolation RF switch. In this paper, a Metal-Oxide-Semiconductor Field Effect Tube (MOSFET) switching circuit is designed to achieve high isolation and low insertion loss at 0.5–3 GHz. This solves the problem that the switching circuit cannot be turned off properly due to the parasitic capacitance of MOSFETs in the process of RF signal transmission, resulting in signal feedthrough. It also ensures that the input signal can be transmitted to the output intact when the switching circuit is turned on. High isolation is achieved by using parallel resonance to increase the voltage division and series resonance to leak the current. The switch achieves 76 dB isolation and 0.07 dB insertion loss at 1 GHz frequency. Isolation is increased by adding parallel branches near the 2 and 3 GHz frequency points, achieving greater than 33 dB isolation from 0.5 to 3 GHz.
Thermal transport of graphene-C3B superlattices and van der Waals heterostructures: a molecular dynamics study
Authors: Zhang Guangzheng , Dong Shilin , Wang Xinyu , Xin Gongming 
Published: October 2023

Abstract
Two-dimensional (2D) materials have attracted more and more attention due to their excellent properties. In this work, we systematically explore the heat transport properties of Graphene-C3B (GRA-C3B) superlattices and van der Waals (vdW) heterostructures using molecular dynamics method. The effects of interface types and heat flow directions on the in-plane interfacial thermal resistance (ITRip) are analyzed. Obvious thermal rectification is detected in the more energy stable interface, GRA zigzag-C3B zigzag (ZZ) interface, which also has the minimum value of ITRip. The dependence of the superlattices thermal conductivity (k) of the ZZ interface on the period length (l

p
) is investigated. The results show that when the l

p
is 3.5 nm, the k reaches a minimum value of 35.52 W m−1 K−1, indicating a transition stage from coherent phonon transport to incoherent phonon transport. Afterwards, the effects of system size, temperature, coupling strength and vacancy defect on the out-of-plane interfacial thermal resistance (ITRop) are evaluated. With the increase of temperature, coupling strength and vacancy defect, ITRop are found to reduce effectively due to the enhanced Umklapp phonon scattering and increased probability of energy transfer. Phonon density of states and phonon participation ratio is evaluated to reveal phonon behavior during heat transport. This work is expected to provide essential guidance for the thermal management of nanoelectronics based on 2D monolayer GRA and C3B.
All-BN distributed Bragg reflectors fabricated in a single MOCVD process
Authors: Ciesielski Arkadiusz , Iwański Jakub , Wróbel Piotr , Bożek Rafał , Kret Sławomir , Turczyński Jakub , Binder Johannes , Korona Krzysztof P , Stępniewski Roman , Wysmołek Andrzej 
Published: October 2023

Abstract
Distributed Bragg Reflectors (DBR) are well-established photonic structures that are used in many photonic applications. However, most of the DBRs are based on different materials or require post-process etching which can hinder integration with other components in the final photonic structure. Here, we demonstrate the fabrication of DBR structures consisting only of undoped boron nitride (BN) layers with high refractive index contrast by using metal–organic chemical vapor deposition (MOCVD). This has been achieved in a single process, without the need for any post-process etching. The difference in the refractive index of the component BN layers stems from different degrees of porosity of the individual BN layers, which is a direct result of a different growth temperature. The fabricated DBR structures consist of 15.5 pairs of BN layers and exhibit a reflectance of 87 ± 1% at the maximum. The wavelength of maximum reflectance can be tuned from 500 nm up to the infrared region (IR), by simply adjusting the growth periods of subsequent BN layers. We also demonstrate that the fabricated structures can be used to create an optical microcavity. The fabricated DBRs are very promising candidates for future applications, for example in combination with single-photon emitters in h-BN, which could allow the building of a cavity-based all-BN single-photon source.
Eco-friendly alkali lignin-assisted water-based graphene oxide ink and its application as a resistive temperature sensor
Authors: Khan Junaid , Mariatti M , Zubir Syazana A , Rusli Arjulizan , Manaf Asrulnizam Abd , Khirotdin Rd Khairilhijra 
Published: October 2023

Abstract
Inkjet-printable ink formulated with graphene oxide (GO) offers several advantages, including aqueous dispersion, low cost, and environmentally friendly production. However, water-based GO ink encounters challenges such as high surface tension, low wetting properties, and reduced ink stability over prolonged storage time. Alkali lignin, a natural surfactant, is promising in improving GO ink’s stability, wettability, and printing characteristics. The concentration of surfactant additives is a key factor in fine-tuning GO ink’s stability and printing properties. The current study aims to explore the detailed effects of alkali lignin concentration and optimize the overall properties of graphene oxide (GO) ink for drop-on-demand thermal inkjet printing. A meander-shaped temperature sensor electrode was printed using the optimized GO ink to demonstrate its practical applicability for commercial purposes. The sensing properties are evaluated using a simple experimental setup across a range of temperatures. The findings demonstrate a significant increase in zeta potential by 25% and maximum absorption by 84.3%, indicating enhanced stability during prolonged storage with an optimized alkali lignin concentration compared to the pure GO dispersions. The temperature sensor exhibits a remarkable thermal coefficient of resistance of 1.21 within the temperature range of 25 °C–52 °C, indicative of excellent sensitivity, response, and recovery time. These results highlight the potential of alkali lignin as a natural surfactant for improving the performance and applicability of inkjet-printable GO inks in various technological applications.
Insights on grain boundary effects on crack formation and propagation in Nb3Sn coatings at low temperature and high strain rates: a molecular dynamics simulation study
Authors: Zhu Benhao , Xiao Gesheng , Yang Lin , Liu Li , Qiao Li 
Published: October 2023

Abstract
Mechanical behavior of Nb3Sn coatings is inherently correlated with the anti-interference ability of the superconducting cavity system and the amplitude and phase stability of the cavity field. We report on atomic-scale simulation and analysis of grain boundary effects on the crack formation and propagation in Nb3Sn coatings at low temperature and high strain rates. For tensile-deformed single crystal Nb3Sn, accompanied by the occurrence of slips, micro voids propagate along the (

2
‾

10

) and (210) planes (stretching the crystal along the [100] direction), and subsequently coalesce, leading to the cracks formation. For tensile-deformed single-crystal Nb3Sn coating on Nb substrate, it fails by crack propagation in the coating before showing significant yielding plateaus. In the Nb3Sn coating, the slip bands on the (201) and (

2
‾

10

) planes meet and merge, inducing the breaking of atomic bonds and the formation of voids at the slip band intersections, and the subsequent micro-crack initiation. The misfit dislocations of Nb3Sn/Nb heterostructure interface and the dislocations nucleated on slip systems control the plastic deformation of the Nb substrate, causing the BCC-to-FCC and FCC-to-HCP phase transformation in the substrate, for which, ductile fracture occurs after necking. For polycrystalline Nb3Sn coating on Nb substrate, the simulations demonstrate that cracks propagate entirely along grain boundaries, exhibiting the intergranular fracture characteristics. The composite exhibits a significant strain rate effect. At high strain rates, crack propagation across grain boundaries in Nb3Sn is hindered, dislocations are emitted into the both adjacent grains from the grain boundary facets, they glide across the grain, and voids are nucleated at the intersections of dislocations inside the grains, which leads to the formation of voids and ultimately the occurrence of trans-crystalline fracture. The findings provide important information about the crack evolution in Nb3Sn coatings, which are critical to the fabrication and performance analysis of Nb3Sn superconducting radio frequency cavities.
Structural, Magnetic, and Mössbauer Investigation of Mg-Ni-Co ferrites doped by Sm3+ sions
Authors: Matar M , Rabaa M , Moussa Ramy M , Hassan R Sayed , Yaacoub N , Awad R 
Published: October 2023

Abstract
Samarium-doped magnesium-nickel-cobalt nanoferrites (Mg1/3 Ni1/3Co1/3)Fe2−xSmxO4, with x = 0.00, 0.01, 0.02, 0.04, and 0.08, were synthesized by the coprecipitation method. X-ray diffractometer (XRD), transmission electron microscopy (TEM), energy dispersive x-ray (EDX), x-ray photoelectric spectroscopy (XPS), Fourier Transform Infra-Red (FTIR), Raman spectroscopy, Mössbauer spectroscopy, and magnetic measurement techniques were used, to study the structure, microstructure, and magnetic properties of the samples. The formation of the cubic spinel structure was confirmed by Rietveld analysis of the XRD data and by the appearance of the two absorption bands close to 400 cm−1 and 600 cm−1 from the FTIR spectrum. Raman spectroscopy verified the formation of the spinel phase in the samples. The elemental composition, valency, and cationic distribution were examined using x-ray photoelectric spectroscopy (XPS) measurements. Experimental findings revealed that doping with Sm3+ ions had a significant effect on the magnetic properties of nanoparticles. The saturation magnetization (M

s
) and coercivity field (H

c
) values fluctuate depending on the crystallite size (DXRD) of the samples from XRD analysis as the Sm3+ content increases. The magnetization dependence on the applied field was investigated at different ranges of applied fields based on the output of the statistical parameters for the curve fitted using four different forms of the law of approach to saturation. The statistical parameters and physically significant fitted parameters give information on the dependence of magnetization over various applied field regions. A thorough investigation of the output parameters from fitting into various equations reveals that the composition of Mg-Ni-Co ferrites exhibits a dependence of magnetization on the applied field. Room-temperature Mössbauer spectra displayed a mix of the magnetic sextet and central quadrupole doublet, with improvement in the magnetic sextet in the Sm-doped samples. Moreover, Mössbauer spectra at 77 K showed the demise of the quadrupole doublet in all samples and showed two sextets (tetrahedral and octahedral sites). Sm-doping reduced the values of the hyperfine magnetic field of both sextets. All Fe ions can be found in the Fe3+ state, according to the isomer shift values and there is a migration of Fe3+ ions from octahedral to tetrahedral sites upon Sm doping, which was confirmed by XPS measurements.