bluuebunny/crossref_metadata_2025_split huggingface dataset:
Jet power extracted from ADAFs and the application to Fermi BL Lacertae objects
Authors: Chen(陈永云) Yongyun , Gu(顾秋生) Qiusheng , Fan(樊军辉) Junhui , Yu(俞效龄) Xiaoling , Ding(丁楠) Nan , Guo(郭晓通) Xiaotong , Xiong(熊定荣) Dingrong 
Published: October 2023

ABSTRACT
We calculate the jet power of the Blandford–Znajek (BZ) model and the hybrid model based on the self-similar solution of advection-dominated accretion flows (ADAFs). We study the formation mechanism of the jets of BL Lacertae (BL Lacs) with known redshifts detected by the Fermi satellite after 10 yr of data (4FGL-DR2). The kinetic power of the jets of Fermi BL Lacs is estimated through radio luminosity. The main results are as follows. (1) We find that the jet kinetic power of about 72 per cent intermediate peak frequency BL Lacs (IBL) and 94 per cent high-frequency peak BL Lacs (HBL) can be explained by the hybrid jet model based on ADAFs surrounding Kerr black holes. However, the jet kinetic power of about 74 per cent low-frequency peak BL Lacs (LBL) cannot be explained by the BZ jet model or the hybrid model. (2) The LBL has a higher accretion rate than IBL and HBL. About 14 per cent IBL and 62 per cent HBL have pure optically thin ADAFs. However, 7 per cent LBL may have a hybrid structure consisting of an standard thin disc (SS) plus optically thin ADAFs. (3) After excluding the redshift dependence, there is a weak correlation between the jet kinetic power and the accretion disc luminosity for Fermi BL Lacs. (4) There is a significant correlation between inverse-Compton luminosity and synchrotron luminosity for Fermi BL Lacs. The slope of the relation between inverse-Compton luminosity and synchrotron luminosity for Fermi BL Lacs is consistent with the synchrotron self-Compton (SSC) process. The result may suggest that the high-energy components of Fermi BL Lacs are dominated by the SSC process.
Interstellar tryptophan revisited
Authors: Hudson Reggie L 
Published: October 2023

ABSTRACT
A recent assignment of the amino acid tryptophan to infrared emission lines in the gas of the IC 348 star cluster is re-examined. A comparison of spectra from the Spitzer Telescope to laboratory data shows that there is no firm support for the tryptophan assignment. Suggestions are made for future observational searches for tryptophan and for supporting laboratory work.
High-redshift supermassive black hole mergers in simulations with dynamical friction modelling
Authors: DeGraf Colin , Chen Nianyi , Ni Yueying , Di Matteo Tiziana , Bird Simeon , Tremmel Michael , Croft Rupert 
Published: October 2023

ABSTRACT
In the near future, projects like Laser Interferometer Space Antenna (LISA) and pulsar timing arrays are expected to detect gravitational waves from mergers between supermassive black holes, and it is crucial to precisely model the underlying merger populations now to maximize what we can learn from this new data. Here, we characterize expected high-redshift (z &gt; 2) black hole mergers using the very large volume Astrid cosmological simulation, which uses a range of seed masses to probe down to low-mass black holes (BHs), and directly incorporates dynamical friction so as to accurately model the dynamical processes that bring black holes to the galaxy centre where binary formation and coalescence will occur. The black hole populations in Astrid include black holes down to $\sim 10^{4.5} \, \mathrm{M}_\odot$, and remain broadly consistent with the TNG simulations at scales $\gt 10^6 \, \mathrm{M}_\odot$ (the seed mass used in TNG). By resolving lower mass black holes, the overall merger rate is ∼5× higher than in TNG. However, incorporating dynamical friction delays mergers compared to a recentring scheme, reducing the high-z merger rate mass-matched mergers by a factor of ∼2×. We also calculate the expected LISA signal-to-noise values, and show that the distribution peaks at high SNR (&gt;100), emphasizing the importance of implementing a seed mass well below LISA’s peak sensitivity ($\sim 10^6 \, \mathrm{M}_\odot$) to resolve the majority of LISA’s gravitational wave detections.
Understanding the broad-band emission process of 3C 279 through long term spectral analysis
Authors: Thekkoth Aminabi , Sahayanathan S , Shah Zahir , Paliya Vaidehi S , Ravikumar C D 
Published: October 2023

ABSTRACT
The long term broad-band spectral study of Flat Spectrum Radio Quasars during different flux states has the potential to infer the emission mechanisms and the cause of spectral variations. To scrutinize this, we performed a detailed broad-band spectral analysis of 3C 279 using simultaneous Swift-XRT/UVOT and Fermi-LAT observations spanning from 2008 August to 2022 June. We also supplement this with the simultaneous NuSTAR observations of the source. The optical/UV, X-ray, and γ-ray spectra were individually fitted by a power law to study the long term variation in the flux and the spectral indices. A combined spectral fit of simultaneous optical/UV and X-ray spectra was also performed to obtain the transition energy at which the spectral energy distribution is minimum. The correlation analysis suggests that the long term spectral variations of the source are mainly associated with the variations in the low energy index and the break energy of the broken power-law electron distribution which is responsible for the broad-band emission. The flux distribution of the source represents a lognormal variability while the γ-ray flux distribution showed a clear double lognormal behaviour. The spectral index distributions were again normal except for γ-ray which showed a double-Gaussian behaviour. This indicates that the lognormal variability of the source may be associated with the normal variations in the spectral index. The broad-band spectral fit of the source using synchrotron and inverse Compton processes indicates different emission processes are active at optical/UV, X-ray, and γ-ray energies.
In situ or accreted? Using deep learning to infer the origin of extragalactic globular clusters from observables
Authors: Trujillo-Gomez Sebastian , Kruijssen J M Diederik , Pfeffer Joel , Reina-Campos Marta , Crain Robert A , Bastian Nate , Cabrera-Ziri Ivan 
Published: October 2023

ABSTRACT
Globular clusters (GCs) are powerful tracers of the galaxy assembly process, and have already been used to obtain a detailed picture of the progenitors of the Milky Way (MW). Using the E-MOSAICS cosmological simulation of a (34.4 Mpc)3 volume that follows the formation and co-evolution of galaxies and their star cluster populations, we develop a method to link the origin of GCs to their observable properties. We capture this complex link using a supervised deep learning algorithm trained on the simulations, and predict the origin of individual GCs (whether they formed in the main progenitor or were accreted from satellites) based solely on extragalactic observables. An artificial neural network classifier trained on ∼50 000 GCs hosted by ∼700 simulated galaxies successfully predicts the origin of GCs in the test set with a mean accuracy of 89 per cent for the objects with $\rm [Fe/H]\lt -0.5$ that have unambiguous classifications. The network relies mostly on the alpha-element abundances, metallicities, projected positions, and projected angular momenta of the clusters to predict their origin. A real-world test using the known progenitor associations of the MW GCs achieves up to 90 per cent accuracy, and successfully identifies as accreted most of the GCs in the inner Galaxy associated to the Kraken progenitor, as well as all the Gaia-Enceladus GCs. We demonstrate that the model is robust to observational uncertainties, and develop a method to predict the classification accuracy across observed galaxies. The classifier can be optimized for available observables (e.g. to improve the accuracy by including GC ages), making it a valuable tool to reconstruct the assembly histories of galaxies in upcoming wide-field surveys.
Natal forest fragment size does not predict fledgling, pre-migration or apparent annual survival in Wood Thrushes
Authors: Hayes Sue M , Boyd Brendan P , Israel Alexandra M , Stutchbury Bridget J M 
Published: October 2023

AbstractDetermining the drivers and mechanisms for first year survival of migratory songbirds has been an understudied area in population dynamics due to the difficulty in tracking juveniles once they have dispersed from the natal site. With the advancement in miniaturization of radio-tags (battery life ~400 days) and the development of the Motus Wildlife Tracking System, we tracked 189 Wood Thrush (Hylocichla mustelina) nestlings through independence and to fall migration departure, and their return the following spring. Natal forest fragment size and landscape forest cover (at different spatial scales) were not strong predictors of fledgling, pre-migration, or apparent annual survival; and onset of fall migration was best predicted by fledge date but not natal fragment size. Survival probability was lowest the first 16 days post-fledging (70%, or 0.86 weekly survival probability), very high for juveniles as they explored the landscape prior to fall migration (89%, or 0.99 weekly survival probability) and low during their first migration and wintering season (26%, or 0.95 weekly survival probability). To our knowledge, this is the first study to directly estimate annual apparent juvenile survival in a migratory songbird using year-round radio-tracking. Our study suggests that small forest fragments are important for the conservation for forest songbirds because they can support high survival of juveniles.
The OsCPK17-OsPUB12-OsRLCK176 module regulates immune homeostasis in rice
Authors: Mou Baohui , Zhao Guosheng , Wang Jiyang , Wang Shanzhi , He Feng , Ning Yuese , Li Dayong , Zheng Xinhang , Cui Fuhao , Xue Fang , Zhang Shiyong , Sun Wenxian 
Published: October 2023

Abstract
Plant immunity is fine-tuned to balance growth and defense. However, little is yet known about molecular mechanisms underlying immune homeostasis in rice (Oryza sativa). In this study, we reveal that a rice calcium-dependent protein kinase (CDPK), OsCPK17, interacts with and stabilizes the receptor-like cytoplasmic kinase (RLCK) OsRLCK176, a close homolog of Arabidopsis thaliana BOTRYTIS-INDUCED KINASE 1 (AtBIK1). Oxidative burst and pathogenesis-related gene expression triggered by pathogen-associated molecular patterns are significantly attenuated in the oscpk17 mutant. The oscpk17 mutant and OsCPK17-silenced lines are more susceptible to bacterial diseases than the wild-type plants, indicating that OsCPK17 positively regulates rice immunity. Furthermore, the plant U-box (PUB) protein OsPUB12 ubiquitinates and degrades OsRLCK176. OsCPK17 phosphorylates OsRLCK176 at Ser83, which prevents the ubiquitination of OsRLCK176 by OsPUB12 and thereby enhances the stability and immune function of OsRLCK176. The phenotypes of the ospub12 mutant in defense responses and disease resistance show that OsPUB12 negatively regulates rice immunity. Therefore, OsCPK17 and OsPUB12 reciprocally maintain OsRLCK176 homeostasis and function as positive and negative immune regulators, respectively. This study uncovers positive cross talk between CDPK- and RLCK-mediated immune signaling in plants and reveals that OsCPK17, OsPUB12, and OsRLCK176 maintain rice immune homeostasis.
COVID-19 lockdown effect on healthcare utilization and in-hospital mortality in children under 5 years in Cape Town, South Africa: a cross-sectional study
Authors: Elmi Noradin , Smit Liezl , Wessels Thandi , Zunza Moleen , Rabie Helena 
Published: October 2023

Abstract

Background
COVID-19 pandemic measures resulted in the de-escalation of non-COVID-19 healthcare provision.

Methods
A retrospective cross-sectional study of routinely collected data was done to investigate the effect of COVID-19 policies on the healthcare utilization and mortality of children younger than 5 years in Eastern Cape Town, South Africa. We compared visits to primary and urgent care facilities, hospitalization, in-hospital deaths, and vaccine uptake from 1 January to 31 December 2020 to similar periods in 2018 and 2019.

Results
During April and May 2020, the most restricted period, visits to primary care facilities declined from 126 049 in 2019 to 77 000 (1.8-fold; p &lt; 0.05). This corresponded with a 1.2-fold reduction in the provision of the first dose of measles vaccine at 6 months compared to 2019. Throughout 2020 there was a 4-fold decline in the number of fully immunized children at 1 year of age (p = 0.84). Emergency room visits fell by 35.7% in 2020 (16 368) compared to 2019 (25 446). Hospital admissions decreased significantly (p &lt; 0.01) in 2020 (9810) compared to 2018 (11 698) and 2019 (10 247). The in-hospital mortality rate increased from 2.3% (96/4163) in 2019 to 3.8% (95/2498) (p &lt; 0.01) in Tygerberg Hospital, where 80% (95/119) of deaths were recorded. Twelve of the 119 (10%) deaths occurred in HIV-positive children (p = &lt;0.01).

Conclusion
Measures instituted during the COVID-19 pandemic disrupted access to healthcare services for children. This resulted in an immediate, and potential future, indirect effect on child morbidity and mortality in Cape Town.
Insights into Phakopsora pachyrhizi Effector–Effector Interactions
Authors: Qi Mingsheng , Yu Haiyue , Bredow Melissa , Chicowski Aline Sartor , Fields Letícia Dias , Whitham Steven A. 
Published: October 2023

The multifaceted role of pathogen-encoded effectors in plant–pathogen interactions is complex and not fully understood. Effectors operate within intricate host environments, interacting with host proteins and other effectors to modulate virulence. The complex interplay between effectors raises the concept of metaeffectors, wherein some effectors regulate the activity of others. While previous research has demonstrated the importance of effector repertoires in pathogen virulence, only a limited number of studies have investigated the interactions between these effectors. This study explores the interactions among Phakopsora pachyrhizi effector candidates ( PpECs). P. pachyrhizi haustorial transcriptome analysis identified a collection of predicted PpECs. Among these, PpEC23 was found to interact with PpEC48, prompting further exploration into their potential interaction with other effectors. Here, we utilized a yeast two-hybrid screen to explore protein–protein interactions between PpECs. A split-luciferase complementation assay also demonstrated that these interactions could occur within soybean cells. Interestingly, PpEC48 displayed the ability to interact with several small cysteine-rich proteins (SCRPs), suggesting its affinity for this specific class of effectors. We show that these interactions involve a histidine-rich domain within PpEC48, emphasizing the significance of structural motifs in mediating effector interactions. The unique nature of PpEC48, showing no sequence matches in other organisms, suggests its relatively recent evolution and potential orphan gene status. Our work reveals insights into the intricate network of interactions among P. pachyrhizi effector–effector interactions. [Formula: see text] Copyright © 2024 The Author(s). This is an open access article distributed under the CC BY 4.0 International license .
Parkland Trauma Index of Mortality in Orthopaedic Trauma Patients: An Initial Report
Authors: Tiziani Simon , Hinkle Andrew J. , Mesarick Enzo C. , Turner Alexander C. , Kenfack Yves J. , Dumas Ryan P. , Grewal Ishvinder S. , Park Caroline , Sanders Drew T. , Sathy Ashoke K. , Starr Adam J. 
Published: October 2023

Objectives:
The extent and timing of surgery in severely injured patients remains an unsolved problem in orthopaedic trauma. Different laboratory values or scores have been used to try to predict mortality and estimate physiological reserve. The Parkland Trauma Index of Mortality (PTIM) has been validated as an electronic medical record–integrated algorithm to help with operative timing in trauma patients. The aim of this study was to report our initial experience with PTIM and how it relates to other scores.

Methods:
A retrospective chart review of level 1 and level 2 trauma patients admitted to our institution between December 2020 and November 2022 was conducted. Patients scored with PTIM with orthopaedic injuries were included in this study. Exclusion criteria were patients younger than 18 years.

Results:
Seven hundred seventy-four patients (246 female patients) with a median age of 40.5 (18–101) were included. Mortality was 3.1%. Patients in the PTIM high-risk category (≥0.5) had a 20% mortality rate. The median PTIM was 0.075 (0–0.89) and the median Injury Severity Score (ISS) was 9.0 (1–59). PTIM (P < 0.001) and ISS (P < 0.001) were significantly lower in surviving patients. PTIM was mentioned in 7.6% of cases, and in 1.7% of cases, providers indicated an action in response to the PTIM. PTIM and ISS were significantly higher in patients with documented PTIM.

Conclusion:
PTIM is better at predicting mortality compared with ISS. Our low rate of PTIM documentation in provider notes highlights the challenges of implementing a new algorithm.

Level of Evidence:
Level III, retrospective cohort study.
Biomimetic Hematoma as a Novel Delivery Vehicle for rhBMP-2 to Potentiate the Healing of Nonunions and Bone Defects
Authors: Glatt Vaida , Tetsworth Kevin 
Published: October 2023

Summary:
The management of bone defects and nonunions creates unique clinical challenges. Current treatment alternatives are often insufficient and frequently require multiple surgeries. One promising option is bone morphogenetic protein-2 (BMP-2), which is the most potent inducer of osteogenesis. However, its use is associated with many side effects, related to the delivery and high doses necessary. To address this need, we developed an ex vivo biomimetic hematoma (BH), replicating naturally healing fracture hematoma, using whole blood and the natural coagulants calcium and thrombin. It is an autologous carrier able to deliver reduced doses of rhBMP-2 to enhance bone healing for complex fractures. More than 50 challenging cases involving recalcitrant nonunions and bone defects have already been treated using the BH delivering reduced doses of rhBMP-2, to evaluate both the safety and efficacy. Preliminary data suggest the BH is currently the only clinically used carrier able to effectively deliver reduced doses (∼70% less) of rhBMP-2 with high efficiency, rapidly and robustly initiating the bone repair cascade to successfully reconstruct complex bone injuries without side effects. The presented case provides a clear demonstration of this technology's ability to significantly alter the clinical outcome in extremely challenging scenarios where other treatment options have failed or are considered unsuitable. A favorable safety profile would portend considerable promise for BH as an alternative to bone grafts and substitutes. Although further studies regarding its clinical efficacy are still warranted, this novel approach nevertheless has tremendous potential as a favorable treatment option for bone defects, open fractures, and recalcitrant nonunions.
Myelomeningocele Defects Reconstruction With Various Types of Keystone Flaps: An Algorithmic Approach Based on Defect Shape
Authors: Hifny Mahmoud A. , Park Tae Hwan , Yagi Shunjiro , Abdelmegeed Ahmed Gaber , El-Shazly Mohamed 
Published: October 2023

The keystone flap has become an established option that has been utilized recently to close significant myelomeningocele defects. Although the keystone flaps can be adapted to repair myelomeningocele defects of different sizes, the shape of the defect is also an essential factor to consider. In this study, the authors proposed an algorithmic approach for reconstructing significant meningomyelocele defects utilizing different types of keystone flaps based on the shape of the resulting defect. From September 2016 to March 2022, the authors retrospectively reviewed the medical records of 28 patients with meningomyelocele who underwent repair with the keystone flaps. The mean age was 28 days (3 days to 4.5 months). Twenty-one meningomyelocele defects were in the lumbosacral (75%) and 7 in the thoracolumbar regions (25%). The defect sizes ranged from 3.5×5 cm (area, 13.4 cm2) to 9×7 cm (area, 49.5 cm2), with an average of 26.2 cm2. Ten meningomyelocele defects were a vertically oriented oval shape, 16 defects were a transversely oriented oval shape, and 2 defects were circular. In addition, unilateral keystone flap was used in 7.1% of the patients (2 patients), bilateral keystone flap in 28.6% (8 patients), and rotation advancement keystone flaps in 64.3% (18 patients). According to these findings, an algorithm was created based on the defect shape. This algorithmic approach is used as a decision-making guide to select the correct type of keystone flaps to repair myelomeningocele according to the defect shape.
Short-term Outcomes of Different Techniques for Gastric Ischemic Pre-Conditioning Before Esophagectomy
Authors: Aiolfi Alberto , Bona Davide , Bonitta Gianluca , Bonavina Luigi ,   Gastric Ischemic Conditioning (GIC) International Collaborative Group,, Cayre Luigi , Guerrazzi Guglielmo , Gutschow Christian A. , Lipham John , Manara Michele , Popa Călin , Rausa Emanuele , Schlanger Diana , Schoppmann Sebastian , Simić Aleksandar , Sozzi Andrea , Zehetner Joerg 
Published: October 2023

Background:
Ischemia at the anastomotic site is a critical protagonist in the development of anastomosis-related complications after esophagectomy. Gastric ischemic conditioning (GIC) before esophagectomy has been described to improve the vascular perfusion at the tip of the gastric conduit with a potential effect on anastomotic leak (AL) and stenosis (AS) risk minimization. Laparoscopic (LapGIC) and angioembolization (AngioGIC) techniques have been reported.

Purpose:
Compare short-term outcomes among different GIC techniques.

Methods:
Systematic review and network meta-analysis. One-step esophagectomy (noGIC), LapGIC, and AngioGIC were compared. Primary outcomes were AL, AS, and gastric conduit necrosis (GCN). Risk ratio (RR) and weighted mean difference (WMD) were used as pooled effect size measures, whereas 95% credible intervals (CrI) were used to assess relative inference.

Results:
Overall, 1760 patients (14 studies) were included. Of those, 1028 patients (58.4%) underwent noGIC, 593 (33.6%) LapGIC, and 139 (8%) AngioGIC. AL was reduced for LapGIC vs. noGIC (RR=0.68; 95% CrI 0.47-0.98) and AngioGIC vs. noGIC (RR=0.52; 95% CrI 0.31-0.93). Similarly, AS was reduced for LapGIC vs. noGIC (RR=0.32; 95% CrI 0.12-0.68) and AngioGIC vs. noGIC (RR=1.30; 95% CrI 0.65-2.46). The indirect comparison, assessed with the network methodology, did not show any differences for LapGIC vs. AngioGIC in term of postoperative AL and AS risk. No differences were found for GCN, pulmonary complications, overall complications, hospital length of stay, and 30-day mortality among different treatments.

Conclusions:
Compared to noGIC, both LapGIC and AngioGIC before esophagectomy seem equivalent and associated with a reduced risk for postoperative AL and AS.