bluuebunny/crossref_metadata_2025_split huggingface dataset:
Implementation of amotosalen plus ultraviolet A‐mediated pathogen reduction for all platelet concentrates in France: Impact on the risk of transfusion‐transmitted infections
Authors: Richard Pascale , Pouchol Elodie , Sandid Imad , Aoustin Laurent , Lefort Caroline , Chartois Anne‐Gaële , Baima Alexis , Malard Lucile , Bacquet Caroline , Ferrera‐Tourenc Virginie , Gallian Pierre , Laperche Syria , Bliem Cathy , Morel Pascal , Tiberghien Pierre 
Published: December 2023

AbstractBackground and ObjectivesPathogen reduction (PR) technology may reduce the risk of transfusion‐transmitted infections (TTIs), notably transfusion‐transmitted bacterial infection (TTBI) associated with platelet concentrates (PCs). PR (amotosalen/UVA treatment) was implemented for all PCs transfused in France in November 2017. No bacterial detection was in place beforehand. The study aimed to assess the impact of PR PC on TTI and TTBI near‐miss occurrences.Materials and MethodsTTI and TTBI near‐miss occurrences were compared before and after 100% PR implementation. The study period ran from 2013 to 2022. Over 300,000 PCs were transfused yearly.ResultsNo PC‐related transmission of human immunodeficiency virus, hepatitis C virus, hepatitis B virus and human T‐cell lymphotropic virus was reported throughout the study period. PC‐mediated hepatitis E virus and hepatitis A virus infections occurred irrespective of PR implementation. Mean PC‐mediated TTBI occurrence before PR‐PC implementation was 3/year (SD: 1; n = 15; 1/92,687 PC between 2013 and 2016) with a fatal outcome in two patients. Since PR implementation, one TTBI has been reported (day 4 PC, Bacillus cereus) (1/1,645,295 PC between 2018 and 2022; p < 0.001). Two PR PC quarantined because of a negative swirling test harboured bacteria: a day 6 PC in 2021 (B. cereus and Staphylococcus epidermidis) and a day 7 PC in 2022 (Staphylococcus aureus). Five similar occurrences with untreated PC were reported between 2013 and 2020.ConclusionTransfusion of 100% PR PC resulted in a steep reduction in TTBI occurrence. TTBI may, however, still occur. Pathogen‐reduced PC‐related TTI involving non‐enveloped viruses occurs as well.
Evaluation of the in vitro performance of the double forwarder knot, compared to square and surgeon's knots using large gauge suture
Authors: Barnes Harriet K. , Munsterman Amelia S. , Gillen Alex M. , Caston Stephanie S. , Tatarniuk Dane M. , Kersh Kevin , Swor Tamara , Hanson R. Reid 
Published: December 2023

AbstractObjectiveThe aim of the study was to evaluate the strength and size of the double forwarder (DF) knot in 2 and 3 USP polyglactin 910 when used to form a ligature and to compare the knot holding capacity (KHC), size and weight of the DF knot to surgeon's (SU) and square (SQ) knots with varying numbers of throws.Study designLaboratory study.Study populationKnotted suture.MethodsKnots were tied using 2 and 3 USP polyglactin 910 and tested on a universal testing machine under linear tension. Mode of failure and (KHC) were recorded. Knot volume and weight were determined by digital micrometer and balance. KHC, size, and weight between knot type, number of throws, and suture type and size were compared using ANOVA testing, with p < .05 as significant.ResultsIn both suture types, DF knots had a higher KHC than SQ/SU knots (p < .004), with the exception of SU knots with 6–8 throws in 3 USP polyglactin 910 (p > .42). All DF knots failed by suture breakage at the knot, as did all SQ/SU knots with >6 throws. DF knots in 2 and 3 USP polyglactin 910 were larger and heavier than SQ and SU knots when the same number of throws was applied (p < .003).ConclusionSelf‐locking DF knots provided increased strength compared to SU/SQ in large gauge suture but only when fewer than six throws are applied to SU/SQ knots.Clinical relevanceThe new DF knot could be an alternative for a secure ligature.
Clinical outcomes for 20 cats with congenital extrahepatic portosystemic shunts treated with ameroid constrictor ring attenuation (2002–2020)
Authors: Janas Krysta E. A. , Tobias Karen M. , Aisa Josep 
Published: December 2023

AbstractObjectiveTo report the clinical perioperative, short‐term, and long‐term outcomes for cats undergoing ameroid ring constrictor (ARC) attenuation of a congenital extrahepatic portosystemic shunt (EHPSS).Study designRetrospective case series from a single veterinary teaching hospital (2002–2020).AnimalsTwenty client‐owned cats with EHPSS.MethodsData collected from medical records included signalment, history, physical examination, clinicopathologic testing, medications, diagnostic imaging, intraoperative findings, perioperative complications, and postoperative clinical outcomes. Long‐term clinical outcome was obtained from a standardized owner interview or medical records.ResultsPerioperative complications were reported in five cats out of 20, including blindness (two cats), ascites (one cat), head pressing (one cat), and seizures and death (one cat). Short‐term clinical outcome was excellent in 14/18 cats, good in 2/18 cats, and poor in 2/18 cats that were available for follow up, and long term clinical outcome was excellent in 15/18, good in 1/18 cats, and poor in 2/18 cats that were available for follow up.ConclusionLong‐term clinical outcome was good or excellent in 16/18 of cats available for follow up. Perioperative complications were reported in five cats.Clinical significanceSurgical attenuation of EHPSS with an ARC can result in resolution of clinical signs and biochemical abnormalities in the majority of cats. The perioperative complication rate for feline patients with EHPSS attenuated with an ARC was lower than reported historically. Seizures may persist in the long term despite normal bile acid stimulation test results, complete blood count, and biochemistry analysis.
Thermochemical Co-Liquefaction of Fruit Pomace’s Blends in a Binary Solvent System Toward Value-Added Bioproducts
Authors: Wądrzyk Mariusz , Janus Rafał , Korzeniowski Łukasz , Plata Marek 
Published: December 2023

Abstract
Poland belongs to the most meaningful producers of fresh food products in the European Union, e.g., apples, cherries, carrots, as well as currants. A significant part of these products are subjected to further processing, which results in the generation of an abundant amount of wet residues, such as pomace. The present paper aims to investigate the possibility of co-processing various industrial residues in the form of fruit pomaces through thermochemical liquefaction toward high-energy-density biocrude and biochar. More specifically, industrial wastes received from commercial juice production, i.e., blackcurrant, apple, and cherry pomaces, were converted under subcritical conditions of the water-isopropyl alcohol solvent system at fixed conditions. Particular focus was put on testing binary and ternary mixture feedstock systems and the possibility of predicting the bioproduct yield. Furthermore, the quality of the resultant biocrudes was analyzed by means of FTIR, GC-MS, and elemental analysis. For all separately studied raw materials and their binary and ternary mixtures, the dominant group fraction was biocrude with its yield ranging between 45.8 and 54.5 wt%. Produced liquids exhibit high energy density (HHV between 30.1 and 32.4 MJ/kg); thus, all of them pose perspective alternative fuels for generating heat and electricity. Also, the solid biochars presented a high energy density (HHV around 24–26 MJ/kg) and can be considered as an alternative energy carrier. The postulated approach aims to increase the flexibility and profitability of future technology of processing useless waste toward value-added bioproducts for the chemical and energy sectors.
Extraction of Equivalent Stress Versus Equivalent Plastic Strain Curve of Necking Material in Tensile Test Without Assuming Constitutive Model
Authors: Shin Hyunho , Kim Sanghoon , Choi Min Kuk , Ju Yongwon 
Published: December 2023

Abstract
An algorithm for extracting the equivalent stress versus equivalent plastic strain curve of a necking material in tensile test is proposed (the curve is called here the equivalent-plastic (EP) stress–strain (SS) curve). The presented algorithm traces the force–elongation curve via iterative finite element (FE) simulations without assuming a constitutive model and is suitable for a general-purpose FE solver available to a general audience. In the FE simulation and experiment, a slightly tapered geometry was employed around the specimen center to stably initiate necking there. The proposed algorithm and mentioned necking initiation method have been applied to extracting the EP SS curve of a high-strength steel material using an axisymmetric specimen. Because necking was initiated stably in simulation at the specimen center for a range of mesh sizes, the convergence of the extracted EP SS curve with the mesh size could be successfully verified. The EP SS curve of the tested material was extracted up to an EP strain of 0.85 with average strain intervals of approximately 2.5 mili-strain. The error values were less than 0.2 and 0.1% after four and seven FE simulations, respectively. The presented algorithm and necking initiation method in simulation can also be used for simultaneously quantifying the fracture EP strain of a necking material in the tensile test.
Early disengagement from HIV pre-exposure prophylaxis services and associated factors among female sex workers in Dar es Salaam, Tanzania: a socioecological approach
Authors: Lichtwarck Hanne Ochieng , Mbotwa Christopher Hariri , Kazaura Method Rwelengera , Moen Kåre , Mmbaga Elia John 
Published: December 2023

IntroductionPre-exposure prophylaxis (PrEP) is an effective HIV prevention tool when taken as prescribed. However, suboptimal use may challenge its real-life impact. To support female sex workers in their efforts to prevent themselves from HIV, it is essential to identify factors that contribute to early disengagement from PrEP care. In this study, we aimed to estimate the risk of early disengagement from PrEP services among female sex workers in Tanzania and associated factors using a socioecological model as a guiding framework.MethodsThe study was conducted as part of a pragmatic mHealth trial for PrEP roll-out in Dar es Salaam in 2021. We estimated the risk of early disengagement, defined as not presenting for the first follow-up visit (within 56 days of enrolment), and its associations with individual, social, behavioural and structural factors (age, self-perceived HIV risk, mental distress, harmful alcohol use, condom use, number of sex work clients, female sex worker stigma and mobility) using multivariable logistic regression models, with marginal standardisation to obtain adjusted relative risks (aRR).ResultsOf the 470 female sex workers enrolled in the study, 340 (74.6%) did not attend the first follow-up visit (disengaged). Mental distress (aRR=1.14; 95% CI 1.01 to 1.27) was associated with increased risk of disengagement. Participants who reported a higher number of clients per month (10–29 partners: aRR=0.87; 95% CI 0.76 to 0.98 and ≥30 partners: aRR=0.80; 95% CI 0.68 to 0.91) and older participants (≥35 years) (RR=0.75; 95% CI 0.56 to 0.95) had a lower risk of disengagement.Conclusions and recommendationsEarly disengagement with the PrEP programme was high. Mental distress, younger age and having fewer clients were risk factors for disengagement. We argue that PrEP programmes could benefit from including mental health screening and treatment, as well as directing attention to younger sex workers and those reporting fewer clients.
Novel tactile bottle neck adaptor facilitates eye drop adherence in visually impaired patients
Authors: Gupta Praveena K , Ishihara Rhys , Zhao Zhenyang , Owji Shahin , Anyama Easy , Schmitz-Brown Mary , Chacin Aisen C , Iyer Bhavani , Friedman David , Ladki Malik Said 
Published: December 2023

PurposeTo test the use of Ring-IT, a novel 3D tactile bottle neck adaptor in topical eye drop adherence in visually impaired patients.MethodsBottle neck ring adaptors with either one, two or three protrusions with cube or sphere endings were designed. In phase 1, low vision was simulated in healthy subjects (n=20) with a 20/200 vision simulator; while in phase 2, visually impaired patients (n=26; 20/70 or worse) were recruited. Subjects were randomised to six combinations of varying protrusions and shapes on medication bottles and asked to identify these traits at different presentations. Responses and time to identify were recorded.ResultsPhase 1: 98.3% of subjects correctly identified the number of protrusions. Mean time to identify was 4.5±6.1 s. Identification success for cube and sphere end pieces were 91.7% and 73.3%, with average time for identification of 9.9±7.6 and 10.9±9.0 s. In phase 2, 92.3% of subjects correctly identified the number of protrusions. Mean time to identify was 6.0±3.0 s. Identification success for cube and sphere end pieces were 78.2% and 74.4%; with average time for identification of 7.5±4.8 and 8.5±5.6 s, respectively.ConclusionsRing-IT was identified with accuracy and speed by both low vision simulated subjects, and by patients with true limited visual capabilities. These tactile bottle neck ring adaptors can be used as an assistive low vision aid device and may increase eye drop regimen adherence in visually impaired patients.
Benzene exposure and risk of lung cancer in the Norwegian Offshore Petroleum Worker cohort: a prospective case-cohort study
Authors: Babigumira Ronnie , Veierød Marit B , Hosgood H Dean , Samuelsen Sven Ove , Bråtveit Magne , Kirkeleit Jorunn , Rothman Nathaniel , Lan Qing , Silverman Debra T , Friesen Melissa C , Shala Nita Kaupang , Grimsrud Tom K , Stenehjem Jo Steinson 
Published: December 2023

ObjectiveThe objective of our study was to examine whether occupational exposure to benzene is associated with lung cancer among males in the Norwegian Offshore Petroleum Workers cohort.MethodsAmong 25 347 male offshore workers employed during 1965–1998, we conducted a case-cohort study with 399 lung cancer cases diagnosed between 1999 and 2021, and 2035 non-cases sampled randomly by 5-year birth cohorts. Individual work histories were coupled to study-specific job-exposure matrices for benzene and other known lung carcinogens. Weighted Cox regression was used to estimate HRs and 95% CIs for the associations between benzene exposure and lung cancer, by major histological subtypes, adjusted for age, smoking and occupational exposure to welding fumes, asbestos and crystalline silica. Missing data were imputed.ResultsFor lung cancer (all subtypes combined), HRs (95% CIs) for the highest quartiles of benzene exposure versus unexposed were 1.15 (0.61 to 2.35) for cumulative exposure, 1.43 (0.76 to 2.69) for duration, and 1.22 (0.68 to 2.18) for average intensity (0.280≤P-trend≤0.741). For 152 adenocarcinoma cases, a positive trend was observed for exposure duration (P-trend=0.044).ConclusionsIn this cohort of offshore petroleum workers generally exposed to low average levels of benzene, we did not find an overall clear support for an association with lung cancer (all subtypes combined), although an association was suggested for duration of benzene exposure and adenocarcinoma. The limited evidence might be due to restricted statistical power.
The Methyltransferases METTL7A and METTL7B Confer Resistance to Thiol-Based Histone Deacetylase Inhibitors
Authors: Robey Robert W. , Fitzsimmons Christina M. , Guiblet Wilfried M. , Frye William J.E. , González Dalmasy José M. , Wang Li , Russell Drake A. , Huff Lyn M. , Perciaccante Andrew J. , Ali-Rahmani Fatima , Lipsey Crystal C. , Wade Heidi M. , Mitchell Allison V. , Maligireddy Siddhardha S. , Terrero David , Butcher Donna , Edmondson Elijah F. , Jenkins Lisa M. , Nikitina Tatiana , Zhurkin Victor B. , Tiwari Amit K. , Piscopio Anthony D. , Totah Rheem A. , Bates Susan E. , Arda H. Efsun , Gottesman Michael M. , Batista Pedro J. 
Published: December 2023

Abstract
Histone deacetylase inhibitors (HDACi) are part of a growing class of epigenetic therapies used for the treatment of cancer. Although HDACis are effective in the treatment of T-cell lymphomas, treatment of solid tumors with this class of drugs has not been successful. Overexpression of the multidrug resistance protein P-glycoprotein (P-gp), encoded by ABCB1, is known to confer resistance to the HDACi romidepsin in vitro, yet increased ABCB1 expression has not been associated with resistance in patients, suggesting that other mechanisms of resistance arise in the clinic. To identify alternative mechanisms of resistance to romidepsin, we selected MCF-7 breast cancer cells with romidepsin in the presence of the P-gp inhibitor verapamil to reduce the likelihood of P-gp-mediated resistance. The resulting cell line, MCF-7 DpVp300, does not express P-gp and was found to be selectively resistant to romidepsin but not to other HDACis such as belinostat, panobinostat, or vorinostat. RNA-sequencing analysis revealed upregulation of the mRNA coding for the putative methyltransferase, METTL7A, whose paralog, METTL7B, was previously shown to methylate thiol groups on hydrogen sulfide and captopril. As romidepsin has a thiol as the zinc-binding moiety, we hypothesized that METTL7A could inactivate romidepsin and other thiol-based HDACis via methylation of the thiol group. We demonstrate that expression of METTL7A or METTL7B confers resistance to thiol-based HDACis and that both enzymes are capable of methylating thiol-containing HDACis. We thus propose that METTL7A and METTL7B confer resistance to thiol-based HDACis by methylating and inactivating the zinc-binding thiol.
KCNQ5 Controls Perivascular Adipose Tissue–Mediated Vasodilation
Authors: Tsvetkov Dmitry , Schleifenbaum Johanna , Wang Yibin , Kassmann Mario , Polovitskaya Maya M. , Ali Mohamed , Schütze Sebastian , Rothe Michael , Luft Friedrich C. , Jentsch Thomas J. , Gollasch Maik 
Published: December 2023

BACKGROUND:
Small arteries exhibit resting tone, a partially contracted state that maintains arterial blood pressure. In arterial smooth muscle cells, potassium channels control contraction and relaxation. Perivascular adipose tissue (PVAT) has been shown to exert anticontractile effects on the blood vessels. However, the mechanisms by which PVAT signals small arteries, and their relevance remain largely unknown. We aimed to uncover key molecular components in adipose-vascular coupling.

METHODS:

A wide spectrum of genetic mouse models targeting
Kcnq3
,
Kcnq4
, and
Kcnq5
genes (
Kcnq3
–/–
,
Kcnq4
–/–
,
Kcnq5
–/–
,
Kcnq5
dn/dn
,
Kcnq4
–/–
/
Kcnq5
dn/dn
, and
Kcnq4
–/–
/
Kcnq5
–/–
), telemetry blood pressure measurements, targeted lipidomics, RNA-Seq profiling, wire-myography, patch-clamp, and sharp-electrode membrane potential measurements was used.

RESULTS:

We show that PVAT causes smooth muscle cell K
V
7.5 family of voltage-gated potassium (K
+
) channels to hyperpolarize the membrane potential. This effect relaxes small arteries and regulates blood pressure. Oxygenation of polyunsaturated fats generates oxylipins, a superclass of lipid mediators. We identified numerous oxylipins released by PVAT, which potentiate vasodilatory action in small arteries by opening smooth muscle cell K
V
7.5 family of voltage-gated potassium (K
+
) channels.

CONCLUSIONS:

Our results reveal a key molecular function of the K
V
7.5 family of voltage-gated potassium (K
+
) channels in the adipose-vascular coupling, translating PVAT signals, particularly oxylipins, to the central physiological function of vasoregulation. This novel pathway opens new therapeutic perspectives.
QLB-NET: A Dense Soil Moisture and Freeze–Thaw Monitoring Network in the Qinghai Lake Basin on the Qinghai–Tibetan Plateau
Authors: Chai Linna , Zhu Zhongli , Liu Shaomin , Xu Ziwei , Jin Rui , Li Xin , Kang Jian , Che Tao , Zhang Yang , Zhang Jinsong , Cui Hongjing , Gao Tiansheng , Xu Tongren , Zhao Shaojie , Pan Xiaoduo , Guo Ge 
Published: December 2023

Abstract
Soil moisture (SM) and soil freeze–thaw (FT) are two relatively active surface parameters that are significant to the sustainable development of the water–land–air–plant–human nexus. Over time, regional or global SM and FT datasets with different spatial resolutions have been developed. In response to the requirements of multiscale product validation and multisource uncertainty tracking, a soil moisture and soil temperature (ST) monitoring network in the Qinghai Lake Basin (QLB-NET) was established in September 2019. The QLB-NET is characterized by densely distributed in situ sites (82 sites) measuring SM and ST at 5-, 10-, and 30-cm depths, with 60 sites in a large-scale network covering an area of 36 km × 40 km and 22 sites evenly distributed across two small-scale 1 km × 1 km networks. Quantitative analyses of the in situ measurements show that the QLB-NET can provide stable and reliable ground truth for SM and FT over coarse grid scales, e.g., 36 km × 36 km, 25 km × 25 km, and 0.25° × 0.25°. When statistics are correspondingly performed over 50 out of 54, 25 out of 29, and 25 out of 28 sites, the results are described as follows: 1) the standard deviation of the mean SM varies between 0.0127 and 0.0196 m3 m−3, with the corresponding difference between the upper and lower quartiles being less than 0.02 m3 m−3; 2) the ground freeze–thaw state can be correctly identified with high probabilities ranging from 85.3% to 100% on two freeze–thaw transitional dates. The QLB-NET observed datasets are distributed online and will be continuously updated through cooperation with the National Tibetan Plateau Data Center (http://data.tpdc.ac.cn), facilitating product validation and uncertainty tracking, spatiotemporal analysis of SM change and FT transition, optimization of the SM and FT retrieving algorithms and scaling methods, and development of the mountainous microwave radiative transfer model.
Responses of Westerly Jets over Asia versus North America in the Last Glacial Maximum and Their Attributions
Authors: Lei Jing , Shi Zhengguo , Sha Yingying , Li Xinzhou , Xie Xiaoning 
Published: December 2023

Abstract
By using the Community Atmosphere Model version 4 (CAM4) coupled to a slab ocean model, the total responses of westerly jets (WJ) over Asia and North America during the Last Glacial Maximum (LGM), as well as the relative influences of different individual LGM forcing on the changes in WJ, are evaluated in this study. The results show that the seasonal variation of Northern Hemisphere WJ in LGM is characterized by distinct regional discrepancies. The WJ is intensified and shifts southward in North America, while it generally weakens and slightly displaces northward in central Asia. Over Japan, the WJ is enhanced and moves southward in summer but is attenuated and shifts northward in winter. The change of WJ has a close relationship with the midtroposphere temperature anomalies which result from the different external forcings. In summer, the ice sheet albedo plays a leading role in wind fields at mid-to-high latitudes of the Northern Hemisphere by causing a zonal wave–like response of temperature. In winter, the ice sheet topography dominates the wind fields across North America to North Atlantic by inducing a northwest–southeast-oriented tripole temperature response. The effects of orbital parameters and greenhouse gases largely contribute to the alteration of upper wind fields over Asia and North Pacific by causing a dipole response of temperature.