bluuebunny/crossref_metadata_2025_split huggingface dataset:
Electrodeposited Ni-Sn-P electrodes for hydrogen evolution electrocatalysis
Authors: Zhou Yanke , Zhang Zhaoyu , Sun Hebin 
Published: December 2023

Abstract
Developing high-activity, Nobel metal-free electrodes is of utmost significance in the context of the hydrogen evolution reaction (HER). In this study, we employed an electrodeposited process to fabricate Ni-Sn-P films on a copper substrate. The microstructure and electrocatalytic properties of these Ni-Sn-P films were thoroughly characterized and subsequently compared to those of the reference Ni-P films.Remarkably, the Ni-Sn-P electrode exhibited an impressively low overpotential of −84 mV at a current density of −10 mA cm−2 in a 1 M NaOH solution. This value was found to be 172 mV lower than that of the Ni-P electrode, thereby establishing the superior electrocatalytic activity of the Ni-Sn-P electrode. Moreover, the excellent electrocatalytic stability of the Ni-Sn-P electrode was demonstrated over a time span of at least 25 h.The exceptional attributes of the Ni-Sn-P electrode can be ascribed to its larger active surface area, lower Tafel slope, and reduced charge transfer resistance. The utilization of Ni-Sn-P films as electrode materials holds great potential in advancing the field of HER due to their enhanced performance compared to conventional Ni-P films.
Sarah Polley’s take on the Me Too moment: adapting Women Talking to the big screen
Authors: Fernández-Morales Marta , Menéndez-Ménendez María Isabel 
Published: December 2023

Abstract
This article discusses Sarah Polley’s 2022 film adaptation of Miriam Toews’ novel Women Talking (2018), inspired by a case of mass rapes in a Mennonite colony in Bolivia, as part of the Me Too moment; a new zeitgeist that has modified the conditions of reception for survivor testimony. We examine it as an audiovisual product that amplifies the resonance of the original text and contributes to the current wave of feminist testimonial practices about sexual violence, constituting an instance of narrative activism that promotes social change. Through our analysis of the dynamics of storytelling in the film, we prove that Polley’s cinematic strategies place emphasis on the women’s lived experiences and points of view, distilling the words of the book to capture the key elements of their discussion (forgiveness, justice, obedience, trauma, and structural violence) and, rarely but significantly, deviating from the original text to achieve her goal of female-centred focalisation. While scholars and survivors have described the battle over the narrative in rape cases, Polley does not leave room for it. In line with #MeToo, the movie takes an ethical listening stand, presenting female testimony as valid evidence. The question at stake is not whether the protagonists have been raped by the men of the colony, but what they are going to do about it; and, by extension, what the viewers are going to make of their story as told by themselves.
ESQmodel: biologically informed evaluation of 2-D cell segmentation quality in multiplexed tissue images
Authors: Lee Eric , Lee Dongkyu , Fan Wayne , Lytle Andrew , Fu Yuxiang ,   IMAXT Consortium, Scott David W , Steidl Christian , Aparicio Samuel , Roth Andrew 
Published: December 2023

Abstract

Motivation
Single cell segmentation is critical in the processing of spatial omics data to accurately perform cell type identification and analyze spatial expression patterns. Segmentation methods often rely on semi-supervised annotation or labeled training data which are highly dependent on user expertise. To ensure the quality of segmentation, current evaluation strategies quantify accuracy by assessing cellular masks or through iterative inspection by pathologists. While these strategies each address either the statistical or biological aspects of segmentation, there lacks a unified approach to evaluating segmentation accuracy.

Results
In this article, we present ESQmodel, a Bayesian probabilistic method to evaluate single cell segmentation using expression data. By using the extracted cellular data from segmentation and a prior belief of cellular composition as input, ESQmodel computes per cell entropy to assess segmentation quality by how consistent cellular expression profiles match with cell type expectations.

Availability and implementation
Source code is available on Github at: https://github.com/Roth-Lab/ESQmodel.
Regional assessment of availability for transcatheter aortic valve implantation in Sweden: a long-term observational study
Authors: Nilsson Konrad , Lindholm Daniel , Backes Jenny , Bjursten Henrik , Hagström Henrik , Lindbäck Johan , Pétursson Pétur , Settergren Magnus , Sarno Giovanna , James Stefan 
Published: December 2023

Abstract

Background
Transcatheter aortic valve implantation (TAVI) is an increasingly important treatment option for patients with severe aortic stenosis. Its best implementation is debated, as few centres with high volumes are associated with better outcomes, while centralization might lead to an inferior availability of treatment for patients living far away. The aim of this study was to investigate the implementation of TAVI in Sweden with a focus on regional differences in terms of availability, short-term mortality, and waiting times.

Methods
All patients undergoing TAVI between 2008 and 2020 from the Swedish Transcatheter Cardiac Intervention Registry (SWENTRY) were included. SWENTRY was linked to the National Cause of Death Registry and to publicly available geospatial data from Statistics Sweden.

Results
A total of 7280 patients were included. Over time, TAVI interventions increased markedly, while surgical aortic valve replacement (SAVR) remained constant. There were no statistically significant regional differences in incidence between counties with or without a local TAVI centre (P = 0.7) and no clustering tendencies around regions with a local TAVI centre (P = 0.99). Thirty-day mortality improved over time without evidence of regional differences. No regional differences in waiting time from decision to intervention were found for TAVI centre regions and non-TAVI centre regions (P = 0.7).

Conclusion
This nationwide study indicated no regional differences in terms of availability, short-term mortality, or waiting times. An organization with a few specialized centres was found to be sufficient to provide national coverage of TAVI interventions.
Taking Back Control? Quasi-Experimental Evidence on the Impact of Retirement on Locus of Control
Authors: Clark Andrew E , Zhu Rong 
Published: December 2023

Abstract
We use Australian panel data to examine the impact of retirement on individual locus of control, a socio-emotional skill with substantial explanatory power for a broad range of life outcomes. Exploiting the eligibility age for the Australian Age Pension, we find that retirement leads to increased internal locus of control. This greater internal control explains around one-third and one-fifth of the positive effects of retirement on health and subjective well-being, respectively. We also show that locus of control is much more malleable at retirement than the other socio-emotional skills of the Big-Five personality traits, risk and time preferences, and trust.
Association between mucosectomy and endoscopic outcomes in patients with ileal pouch–anal anastomosis
Authors: Hembree Amy , Shen Bo , Freedberg Daniel 
Published: December 2023

Abstract

Background
In patients with inflammatory bowel disease (IBD) for whom medical therapy is unsuccessful or who develop colitis-associated neoplasia, restorative proctocolectomy with ileal pouch–anal anastomosis (IPAA) is often indicated. One consideration for surgeons performing this procedure is whether to create this anastomosis using a stapled technique without mucosectomy or using a hand-sewn technique with mucosectomy. This study tested the association between IPAA anastomosis technique and cuffitis and/or pouchitis, assessed endoscopically.

Methods
This was a retrospective cohort study. We included consecutive adult patients with IBD who had undergone IPAA and had received index pouchoscopies at Columbia University Irving Medical Center between 2020 and 2022. Patients were then followed up from this index pouchoscopy for ≤12 months to a subsequent pouchoscopy. The primary exposure was mucosectomy vs non-mucosectomy and the primary outcome was cuffitis and/or pouchitis, defined as a Pouch Disease Activity Index endoscopy subscore of ≥1.

Results
There were 76 patients who met study criteria including 49 (64%) who had undergone mucosectomy and 27 (36%) who had not. Rates of cuffitis and/or pouchitis were 49% among those with mucosectomy vs 41% among those without mucosectomy (P = 0.49). Time-to-event analysis affirmed these findings (log-rank P = 0.77). Stricture formation was more likely among patients with mucosectomy compared with those without mucosectomy (45% vs 19%, P = 0.02).

Conclusions
There was no association between anastomosis technique and cuffitis and/or pouchitis among patients with IBD. These results may support the selection of stapled anastomosis over hand-sewn anastomosis with mucosectomy.
Phased genomics reveals hidden somatic mutations and provides insight into fruit development in sweet orange
Authors: Wang Nan , Chen Peng , Xu Yuanyuan , Guo Lingxia , Li Xianxin , Yi Hualin , Larkin Robert M , Zhou Yongfeng , Deng Xiuxin , Xu Qiang 
Published: December 2023

AbstractAlthough revisiting the discoveries and implications of genetic variations using phased genomics is critical, such efforts are still lacking. Somatic mutations represent a crucial source of genetic diversity for breeding and are especially remarkable in heterozygous perennial and asexual crops. In this study, we focused on a diploid sweet orange (Citrus sinensis) and constructed a haplotype-resolved genome using high fidelity (HiFi) reads, which revealed 10.6% new sequences. Based on the phased genome, we elucidate significant genetic admixtures and haplotype differences. We developed a somatic detection strategy that reveals hidden somatic mutations overlooked in a single reference genome. We generated a phased somatic variation map by combining high-depth whole-genome sequencing (WGS) data from 87 sweet orange somatic varieties. Notably, we found twice as many somatic mutations relative to a single reference genome. Using these hidden somatic mutations, we separated sweet oranges into seven major clades and provide insight into unprecedented genetic mosaicism and strong positive selection. Furthermore, these phased genomics data indicate that genomic heterozygous variations contribute to allele-specific expression during fruit development. By integrating allelic expression differences and somatic mutations, we identified a somatic mutation that induces increases in fruit size. Applications of phased genomics will lead to powerful approaches for discovering genetic variations and uncovering their effects in highly heterozygous plants. Our data provide insight into the hidden somatic mutation landscape in the sweet orange genome, which will facilitate citrus breeding.
Lskipk Lsatpase double mutants are necessary and sufficient for the compact plant architecture of butterhead lettuce
Authors: Xie Sai , Luo Guangbao , An Guanghui , Wang Bincai , Kuang Hanhui , Wang Xin 
Published: December 2023

Abstract
Lettuce, an important leafy vegetable crop worldwide, has rich variations in plant architecture. Butterhead lettuce, a popular horticultural type, has a unique plant architecture with loose leafy heads. The genetic and molecular mechanisms for such a compact plant architecture remain unclear. In this study we constructed a segregating population through crossing a butterhead cultivar and a stem lettuce cultivar. Genetic analysis identified the LsKIPK gene, which encodes a kinase, as the candidate gene controlling butterhead plant architecture. The Lskipk gene in the butterhead parent had a nonsense mutation, leading to a partial predicted protein. CRISPR/Cas9 and complementation tests verified its functions in plant architecture. We showed that the loss of function of LsKIPK is necessary but not sufficient for the butterhead plant architecture. To identify additional genes required for butterhead lettuce, we crossed a butterhead cultivar and a crisphead cultivar, both with the mutated Lskipk gene. Genetic mapping identified a new gene encoding an ATPase contributing to butterhead plant architecture. Knockout and complementation tests showed that loss of function of LsATPase is also required for the development of butterhead plant architecture. The Lskipk Lsatpase double mutation could reduce leaf size and leaf angle, leading to butterhead plant architecture. Expression and cytology analysis indicated that the loss of function of LsKIPK and LsATPase contributed to butterhead plant architecture by regulating cell wall development, a regulatory mechanism different from that for crisphead. This study provides new gene resources and theory for the breeding of the crop ideotype.
Epidemiology of ventilator-associated tracheobronchitis and ventilator-associated pneumonia caused by multidrug-resistant Gram-negative bacteria at a tertiary care hospital in Thailand
Authors: Kajeekul Rattagarn , Thamlikitkul Visanu , Wonglaksanapimon Suvimon , Rattanaumpawan Pinyo 
Published: December 2023

Abstract

Objectives
To investigate the epidemiology of MDR Gram-negative bacilli ventilator-associated tracheobronchitis (MDR GNB-VAT) and MDR GNB ventilator-associated pneumonia (MDR GNB-VAP) among mechanically ventilated patients.

Methods
We conducted a retrospective observational study among hospitalized patients who underwent continuous mechanical ventilation for ≥48 h at Siriraj Hospital, Thailand.

Results
During the 18 month study period, 1824 unique patients underwent continuous mechanical ventilation (12 216 ventilator-days). The cumulative incidences of MDR GNB-VAT and -VAP were 8.4% and 8.3%, respectively. The incidence rates of MDR GNB-VAT and -VAP were 12.52 and 12.44 episodes/1000 ventilator-days, respectively. Among those with VAT, the cumulative incidence and incidence rate of subsequent VAP development within 7 days were 11.76% and 2.81 episodes/1000 ventilator-days, respectively. The median durations of mechanical ventilation before having VAP and VAT were 9 and 12 days, respectively. Multivariate analysis identified three independently associated factors for patients having VAP compared with having VAT: underlying cerebrovascular disease [adjusted OR (aOR): 0.46; 95% CI: 0.27–0.78; P = 0.04], previous surgery (aOR: 0.68; 95% CI: 0.57–0.8; P &lt; 0.001) and acute renal failure (aOR: 1.75; 95% CI: 1.27–2.40; P = 0.001).

Conclusions
The study revealed high incidences of MDR GNB-VAT and -VAP among mechanically ventilated patients. The independent risk factors for having VAP can help identify patients at risk for developing VAP and who need early weaning from mechanical ventilation.
Public perception and community-level impact of national action plans on antimicrobial resistance in Vietnam
Authors: Thomas Shruthi Anna , Mathew Philip , Ranjalkar Jaya , Nguyen Thi Bich Van , Giao Vu Thi Quynh , Chandy Sujith J 
Published: December 2023

Abstract

Objectives
Vietnam was the first country from the WHO Western Pacific Region to adopt a national action plan (NAP) on antimicrobial resistance (AMR) in 2013. The multilayered nature of AMR requires coordination across ‘One Health’ sectors, dedicated financing, multistakeholder involvement, and widespread community engagement to implement the action plans. This study explores the perceived impact of NAP implementation at the community level.

Methods
Key informant interviews (KIIs) were used for data collection during 2021. An interview tool was used for the KIIs and purposive sampling was used to identify study participants from Vietnam. The study participants were those engaged with a substantial scale of antimicrobial usage, diagnosis of infections or concerned with antimicrobial content in effluents in their professional life. Twelve KIIs were conducted with participants from human health, animal health and the environmental sector. The data were entered into Microsoft Excel, and manifest and latent content analysis was done.

Results
The analysis highlighted themes such as limited public awareness of AMR, ongoing capacity building and quality assurance initiatives, implementation of guidelines and regulations for AMR containment, sustained investment in improving infrastructure, and challenges relating to accountability whilst prescribing and selling antibiotics.

Conclusions
There were many positive critical developments during the NAP implementation period in Vietnam towards AMR mitigation. For better impact, there is a need to revitalize the implementation machinery of NAPs by improving the enforcement capacity of regulations, cross-sectoral collaboration and promoting community ownership.
Adenomyoepithelioma of the Breast: Radiologic-Pathologic Correlation and Management
Authors: Smith Katherine A , Solanki Malvika H , Glazebrook Katrina N 
Published: December 2023

Abstract
Adenomyoepithelioma (AME) is a rare, usually benign breast neoplasm with low potential for malignant transformation. Imaging features are nonspecific and overlap with other benign and malignant breast lesions. On mammography, AME most often presents as a mass, usually oval in shape, with variable reported margins. Less commonly, AME can present mammographically as an asymmetry or can be mammographically occult. Associated calcifications are uncommon. On US, AME is usually seen as a hypoechoic oval mass, but it can also manifest as a complex cystic and solid mass. On US, the majority of AME have noncircumscribed margins (indistinct, angular, or microlobulated). Internal vascularity is usually present, and posterior enhancement can be seen. Although there is limited literature on MRI features, the most frequent finding is an irregular mass with washout kinetics; T2 hyperintensity can be observed. These nonspecific and often suspicious imaging features usually merit biopsy. On histologic analysis, AME is characterized by a biphasic proliferation of myoepithelial and epithelial cells. Pathologic diagnosis can be difficult due to the variety of histologic features of AME and heterogeneity in these tumors, especially when sampling is limited, such as in core needle biopsies. Wide local surgical excision of AME is recommended due to potential for recurrence and malignant transformation.
Psychosocial work conditions and traffic safety among minibus and long-bus drivers
Authors: Amoadu Mustapha , Ansah Edward Wilson , Sarfo Jacob Owusu 
Published: December 2023

Abstract
Objective: This study sought to examine the association between psychosocial work factors and road traffic crashes (RTCs), and test the differences in psychosocial work factors between minibus and long-bus drivers.
Methods: This cross-sectional survey employed a convenient sampling method to collect data from 7315 long-distance minibus and long-bus drivers who operate between the Ghanaian cities, Accra and Tema and other parts of the country. The drivers answered a job content questionnaire, psychosocial safety climate scale (PSC-12), work–family conflict scale, and demographic questions on age, education, driving hours, and RTC history.
Results: The correlational analysis showed a significant association between psychosocial work factors and RTCs for the previous 2 years. Hierarchical multiple linear regression found that supervisor support, skill discretion, decision autonomy, psychological demands, PSC, and work–family conflict significantly contributed to explaining RTC rates among the drivers. Also, significant differences were found between minibus and long-bus drivers in driving hours, occurrence of near misses, RTCs, and all psychosocial work factors explored in this study except work–family conflict.
Conclusions: Psychosocial work factors directly predict RTCs among minibus and long-bus drivers. Policymakers, driver unions, and owners and managers of bus transport businesses should prioritize integrating occupational health and safety into road transport activities. Furthermore, managers and bus owners should use bottom-up communication, provide access to support services and work-family balance initiatives, flexible work schedules, and a supportive work environment to improve road safety.
Radiological imaging protection: a study on imaging dose used while planning computed tomography for external radiotherapy in Japan
Authors: Kito Satoshi , Suda Yuhi , Tanabe Satoshi , Takizawa Takeshi , Nagahata Tomomasa , Tohyama Naoki , Okamoto Hiroyuki , Kodama Takumi , Fujita Yukio , Miyashita Hisayuki , Shinoda Kazuya , Kurooka Masahiko , Shimizu Hidetoshi , Ohno Takeshi , Sakamoto Masataka 
Published: December 2023

Abstract
Previous studies have primarily focused on quality of imaging in radiotherapy planning computed tomography (RTCT), with few investigations on imaging doses. To our knowledge, this is the first study aimed to investigate the imaging dose in RTCT to determine baseline data for establishing national diagnostic reference levels (DRLs) in Japanese institutions. A survey questionnaire was sent to domestic RT institutions between 10 October and 16 December 2021. The questionnaire items were volume computed tomography dose index (CTDIvol), dose–length product (DLP), and acquisition parameters, including use of auto exposure image control (AEC) or image-improving reconstruction option (IIRO) for brain stereotactic irradiation (brain STI), head and neck (HN) intensity-modulated radiotherapy (IMRT), lung stereotactic body radiotherapy (lung SBRT), breast-conserving radiotherapy (breast RT), and prostate IMRT protocols. Details on the use of motion-management techniques for lung SBRT were collected. Consequently, we collected 328 responses. The 75th percentiles of CTDIvol were 92, 33, 86, 23, and 32 mGy and those of DLP were 2805, 1301, 2416, 930, and 1158 mGy·cm for brain STI, HN IMRT, lung SBRT, breast RT, and prostate IMRT, respectively. CTDIvol and DLP values in institutions that used AEC or IIRO were lower than those without use for almost all sites. The 75th percentiles of DLP in each treatment technique for lung SBRT were 2541, 2034, 2336, and 2730 mGy·cm for free breathing, breath holding, gating technique, and real-time tumor tracking technique, respectively. Our data will help in establishing DRLs for RTCT protocols, thus reducing imaging doses in Japan.
Deciphering and integrating invariants for neural operator learning with various physical mechanisms
Authors: Zhang Rui , Meng Qi , Ma Zhi-Ming 
Published: December 2023

ABSTRACT
Neural operators have been explored as surrogate models for simulating physical systems to overcome the limitations of traditional partial differential equation (PDE) solvers. However, most existing operator learning methods assume that the data originate from a single physical mechanism, limiting their applicability and performance in more realistic scenarios. To this end, we propose the physical invariant attention neural operator (PIANO) to decipher and integrate the physical invariants for operator learning from the PDE series with various physical mechanisms. PIANO employs self-supervised learning to extract physical knowledge and attention mechanisms to integrate them into dynamic convolutional layers. Compared to existing techniques, PIANO can reduce the relative error by 13.6%–82.2% on PDE forecasting tasks across varying coefficients, forces or boundary conditions. Additionally, varied downstream tasks reveal that the PI embeddings deciphered by PIANO align well with the underlying invariants in the PDE systems, verifying the physical significance of PIANO.