bluuebunny/crossref_metadata_2025_split huggingface dataset:
IBN ʿARABĪ: IL LIBRO DELL’ESSENZA DI CIÒ CHE È INDISPENSABILE PER L’ASPIRANTE (KITĀB KUNH MĀ LĀ BUDDA LI-L-MURĪD MIN-H)
Authors: Marconi Maurizio 
Published: December 2023

Resumen: introducción a la edición y traducción del Kunh mā lā budda li-l-murīd min-hu de Ibn ʿArabī.
Abstract: introduction to the edition and translation of Kunh mā lā budda li-l-murīd min-hu of Ibn ʿArabī.
Percepción de las fuentes de apoyo que facilitan la adherencia a los tratamientos
Authors: Lasmarías-Ugarte María-Concepción , Rubio-Garrido Patricia , Jiménez-Herrera María , Bazo-Hernández Leticia , Martorell-Poveda María-Antonia 
Published: December 2023

Introduction: Non-adherence to treatments increases the probability of therapeutic failure and unnecessary complications.Objective: To explore the sources of support perceived by patients with chronic diseases that facilitate adherence to treatment. Method: Qualitative descriptive study with a phenomenological approach, in which eight complex chronic patients were recruited, without distinction of gender or age, residents of Barcelona, and who, after evaluating pharmacological adherence with the Morisky-Green test and the test of Batalla resulted in being adherent to the therapeutic regimen. After which, two open questions were asked that were recorded on an audio device and transcribed verbatim. For data analysis, the method Colaizzi was used. Results: Three thematic groups emerged: 1) Having family support; 2) Understanding of the disease and strategies that facilitate adherence to treatments; and 3) Relationship with reference professionals. Conclusions: The most important source of support perceived by the participants is the family, coinciding with other authors. The finding of this study is that shows medicine and nursing are evidenced as instigators that promote their empowerment and as a recognized source of influence that has allowed their assimilation and training to adopt measures that help them follow the pharmacotherapeutic guidelines.
Introducción: La falta de adherencia a los tratamientos aumenta la probabilidad de fracaso terapéutico y complicaciones innecesarias. Objetivo: Explorar las fuentes de apoyo percibidas por los pacientes con enfermedades crónicas que les facilitan la adherencia a los tratamientos. Método: Estudio cualitativo descriptivo con enfoque fenomenológico, en el que se reclutaron ocho pacientes crónicos complejos, sin distinción de género, ni edad, residentes en Barcelona, y que tras evaluar la adherencia farmacológica con los test de Morisky-Green y el test de Batalla diera como resultado ser adherente al régimen terapéutico. Tras lo cual se efectuaron dos preguntas abiertas que fueron grabadas en un dispositivo de audio y transcritas textualmente. Para el análisis de los datos, se utilizó el método Colaizzi. Resultados: Surgieron tres grupos temáticos: 1) Tener el apoyo familiar; 2) Comprensión de la enfermedad y estrategias que facilitan la adhesión a los tratamientos; y 3) Relación con los profesionales de referencia. Conclusiones: La fuente más importante de apoyo percibida por los participantes, es la familia, coincidiendo con otros autores. El hallazgo de este estudio, es que se evidencia a medicina y enfermería como instigadores que fomentan su empoderamiento y como fuente de influencia reconocida que ha permitido su asimilación y capacitación para adoptar medidas que les ayudan a seguir las pautas farmacoterapéuticas.
НӘРЕСТЕЛІК ТЕРІ ГЕМАНГИОМАЛАРЫНЫҢ ДИФФЕРЕНЦИАЛДЫ ДИАГНОСТИКАСЫ (ӘДЕБИЕТТІК ШОЛУ)
Authors: Суханбердиева З.М. 
Published: December 2023

Инфантильные гемангиомы наиболее часто встречаемые сосудистые опухоли детского возраста, диагностика которых не представляет особой трудности. Однако, дифференциальная диагностика с другими сосудистыми образованиями представляет определенные трудности. Статья посвящена особенностям клинического течения гемангиом, особенностям при инструментальных методах обследования, используемых при диагностике сосудистых образований. Правильно установленный диагноз помогает выбрать тактику ведения пациентов и исключить диагностические ошибки, которые могут привести к развитию осложнений.
Infantile hemangiomas are the most frequent vascular tumors of the childhood that have easily recognized clinical features. However, the diagnosis between infantile hemangiomas and other vascular disorders may have some difficulties. This article describes the different clinical signs of hemangiomas and investigations that are needed to diagnose the other vascular anomalies. Knowledge on differential diagnosis helps clinicians to make the correct diagnosis, make the correct treatment of hemangiomas, and exclude the possibility of mistakes that can lead to complications.
ПСОРИАЗДЫҢ АДЪЮВАНТТЫ ТЕРАПИЯСЫНДАҒЫ DUCRAY ҰСЫНҒАН KERTYOL PSO КОНЦЕНТРАТТЫ КРЕМІНІҢ ҚОЛДАНУ ТӘЖІРИБЕСІ
Authors: Будесова Ж.У. , Ташбаева Г.А. 
Published: December 2023

В статье описан опыт применения крема-концентрата Kertyol PSO от Ducray в качестве адъюванта у больных псориазом на фоне местной и/или системной терапии. Показано, что включение увлажняющего крема-концентрата Кертиоль P.S.O. в состав комплексной терапии больных бляшечным псориазом способствует более раннему началу стабилизации и регрессу псориатического процесса, купированию субъективных расстройств, повышению качества жизни больных псориазом. При использовании крема-концентрата отмечено отчетливое уменьшение сухости кожи с нормализацией показателей её увлажненности и эластичности, при применении в фазе прогрессирования дерматоза – выраженное противовоспалительное и увлажняющее действие.
The article describes the experience of using Kertyol PSO cream concentrate from Ducray as an adjuvant in patients with psoriasis on the background of local and/or systemic therapy. It is shown that the inclusion of Kertyol P.S.O. moisturizing cream concentrate in the complex therapy of patients with plaque psoriasis contributes to an earlier start of stabilization and regression of the psoriatic process, relief of subjective disorders, and improvement of the quality of life of patients with psoriasis. When using the cream concentrate, there was a distinct decrease in dryness of the skin with normalization of its moisture and elasticity, when used in the phase of dermatosis progression, there was a pronounced anti-inflammatory and moisturizing effect.
Design Smart Door Locks With Internet Of Things Based On Pin Security Features
Authors: Fachrid Wadly  
Published: December 2023

Smart door lock systems have become an interesting topic of research in recent years due to the need for higher security when accessing rooms or buildings. This research aims to design and implement a smart door lock system that uses an Internet of Things (IoT)-based personal identification number (PIN) that can be controlled through the Telegram messaging platform.
The system is designed so that users can give commands via Telegram messages to open or lock doors securely. Users can access the door without needing to be physically near it. In addition, the level of security is enhanced by allowing only authorized users to control the door via Telegram messages, as well as by implementing strong encryption and authentication mechanisms.
In conclusion, this study succeeded in designing and implementing an IoT-based smart door lock system that can be controlled through the Telegram messaging platform using a personal identification number (PIN) as a security method. This system provides an efficient, secure, and practical solution for managing smart door access remotely. It is expected that this research can make a positive contribution to the development of smart door security technology and IoT applications at large
Características Clínicas y Epidemiológicas de la Candidiasis Nosocomial del Torrente sanguíneo en el Instituto Nacional de Salud del Niño
Authors: Ormeño Julca Alexis , Candela Herrera Jorge 
Published: December 2023

Introducción: Las infecciones nosocomiales (IN) por Candida sp. han incrementado la morbilidad y mortalidad hospitalaria en la última década. Representan las infecciones micóticas más frecuentes en pacientes hospitalizados y constituyen la cuarta causa más frecuente de IN hematógena en los Estados Unidos de América.
Objetivo: Determinar las características clínicas y epidemiológicas de los pacientes con Infección del Torrente Sanguíneo (ITS) por Candida de adquisición nosocomial en los diferentes servicios del Instituto Nacional de Salud del Niño (INSN).
Métodos: Se revisó las historias clínicas de todos los pacientes con hemocultivo positivo según registro del Servicio de Microbiología del INSN desde Enero a Diciembre del 2009 y que cumplieron con los criterios de inclusión establecidos para ITS. Para el análisis estadístico se utilizó el paquete estadístico SPSS 11.10 para Windows.
Resultados: Las especies de Candida no albicans se aislaron en el 71,7% de todas las muestras, siendo C. parapsilosis la especie más frecuente (30%). Los pacientes donde se realizaron la mayoría de aislamientos fueron los hospitalizados en los servicios de Cirugía, UCI y Gastroenterología. El grupo etáreo más frecuentemente afectado fueron los menores de un año. Los factores de riesgo intrínsecos más frecuentes fueron ser portador de una malformación congénita, desnutrición y la colonización por Candida y entre los extrínsecos el uso previo de antibióticos de amplio espectro, el uso de catéter venoso central, la cirugía previa abdominal, nutrición parenteral y la intubación con ventilación mecánica. La letalidad bruta de candidemia nosocomial en el INSN fue de 45%.
Conclusión: Las especies de Candida no albicans son cada vez más frecuentemente aisladas en ITS de adquisición nosocomial, siendo los factores de riesgo extrínsecos más frecuentes el uso previo de antibiótico de amplio espectro, catéter venoso central, cirugía previa abdominal, nutrición parenteral total y la intubación con ventilación mecánica. La población generalmente afectada es la de los lactantes menores de un año portadores de una malformación congénita.
Academic and On the Job Training Performance of Business Administration Students of STI West Negros University
Authors: Villanueva Mima M. , Arca Edna Maricon , Sigaya Jr. Salvador S. 
Published: December 2023

This descriptive-correlational study was conducted to determine whether significant relationship exists between academic and on-the-job training (OJT) performances of seventy-five business administration marketing management major students of STI West Negros University for School Year 2018-2019. The academic performance was measured through the general weighted average (GWA) of students for all their subjects since their first year until the third year in the program. The OJT performance, on the other hand, was sourced out from the appraisal made by the host- company supervisors in the aspects of technical competence, attitude, quality of work, quantity of work, inter-personal relationship, and punctuality and attendance during the first semester of their last year in the program. The study revealed a humble rating of satisfactory in the academic of performance (GWA= 85.36, SD= 2.944) of the students but a very good rating in OJT (M=94.467, SD=4.5182). Subsequent results indicated that students performed very well during their OJT training, surpassing their own performance in school, and suggesting that the curriculum have prepared the students in terms of knowledge, skills and attitude for their meaningful immersion in the industry. The study also revealed no significant relationship between GWA in one hand and technical competence, quality of work and quantity of work on the other hand. As a final point, significant relationship was found in the areas of attitude (p=.012), inter-personal relationship (p=.029), and punctuality and attendance (p=.034).
Sustainable Livelihood Program for Purok Arao, Barangay Vista Alegre, Bacolod City, Negros Occidental, Philippines
Authors: Villanueva Mima M. , Sigaya Salvador S. , Arca Edna Maricon A. , Pedrosa Eugenio A. 
Published: December 2023

This paper assessed the workability of a sustainable livelihood program for poor urban dwellers relocated to Purok Arao, Barangay Vista Alegre, in Bacolod City, Negros Occidental, Philippines in line with the government’s poverty-alleviation initiatives. The program’s viability was analyzed in reference to respondents’ socio-economic profile, skills training needs, and a host of anticipated issues and concerns within the community. Data needed were collected using a self-made survey questionnaire, which was administered to randomly sampled respondents (N=817; n=269). Said data were later complemented by a focus-group discussion (FGD) with ten (10) selected participants fairly representing all segments of the community. Initial data analysis characterized the respondents’ demographic profile with the older residents outnumbering the younger ones, the females surpassing the males, and the married outstripping the single, widowed, and separated ones combined. Additional data reveal that less than 50% of the residents are high school graduates, but 77% of them own a house. The majority recorded a meager family income of Php8,450, which was attributable to their low educational attainment and limited skills in cooking, personal services, and construction work. Subsequent analysis revealed the respondents’ preferred livelihood skills in food and beverage, baking/pastry making, dressmaking, tailoring, culinary arts, automotive servicing, food preservation, electrical servicing, welding, beauty care, cosmetology, massage therapy, and communication and information technology. These findings call for a methodical selection of target beneficiaries, continuous skills training development program, cultivation of entrepreneurial mindset, and strengthening partnership with LGUs and other NGOs to bankroll the proposed sustainable development livelihood program.
Variantes no gene ATM (ataxia-telangiectasia, mutado) em Pacientes portadoras de câncer de mama no estado da Bahia
Authors: Ferreira Thâmara Cláudia de Melo , Toralles Maria Betânia Pereira 
Published: December 2023

Introdução: o câncer de mama é o mais comum em mulheres em todo o mundo, com altas taxas de mortalidade. Aproximadamente 10% dos novos casos de câncer de mama são hereditários. A principal síndrome de predisposição hereditária ao câncer de mama é provocada por mutações nos genes BRCA1 e BRCA2, (HBOC, para hereditary breast and ovary cancer). Entretanto, apenas 10% dos pacientes confirmam a presença de mutações germinativas em BRCA1 ou BRCA2. Variantes patogênicas em outros genes, conhecidos como de moderada penetrância, como PALB2, CHEK2 e ATM, também contribuem para aumento do risco de ocorrência do câncer de mama. Cerca de 3 a 5% das mulheres que se apresentam para avaliação de risco hereditário de câncer de mama ou ovário têm variantes patogênicas em um gene de moderada penetrância. Objetivo: descrever os aspectos clínicos e moleculares de pacientes que apresentaram mutações no gene ATM e foram submetidos a aconselhamento genético e teste genético com painel multigenes para genes de alto e moderado risco para câncer. avaliados no período de 2007 a 2023. Metodologia: estudo estatístico descritivo, com análise quantitativa em amostra retrospectiva e prospectiva de pacientes submetidas a sequenciamento por Sanger, admitidas no serviço de oncogenética da UFBA, no ICS da UFBA, bem como de pacientes submetidas a sequenciamento de nova geração, que preencheram critérios clínicos para síndrome de susceptibilidade ao câncer hereditário, com base em critérios dos guidelines do NCCN e conforme diretrizes da Agência Nacional de Saúde, constantes no rol de procedimentos em saúde, admitidas para aconselhamento genético no período de 07/2007 a 05/2023. Resultados: os achados podem elucidar diferenças entre pacientes caucasianos e pacientes miscigenados, esses últimos pouco estudados até o presente momento, mas que podem representam a população brasileira em sua maioria. Conclusão: os resultados encontrados possibilitam o delineamento do perfil dos pacientes com mutação em ATM: epidemiológico, de variabilidade genética ou alélica, perfil clínico, tumoral e de apresentação de tumores na história familiar.
Plasma Biomarker Strategy for Selecting Patients With Alzheimer Disease for Antiamyloid Immunotherapies
Authors: Mattsson-Carlgren Niklas , Collij Lyduine E. , Stomrud Erik , Pichet Binette Alexa , Ossenkoppele Rik , Smith Ruben , Karlsson Linda , Lantero-Rodriguez Juan , Snellman Anniina , Strandberg Olof , Palmqvist Sebastian , Ashton Nicholas J. , Blennow Kaj , Janelidze Shorena , Hansson Oskar 
Published: December 2023

ImportanceAntiamyloid immunotherapies against Alzheimer disease (AD) are emerging. Scalable, cost-effective tools will be needed to identify amyloid β (Aβ)–positive patients without an advanced stage of tau pathology who are most likely to benefit from these therapies. Blood-based biomarkers might reduce the need to use cerebrospinal fluid (CSF) or positron emission tomography (PET) for this.ObjectiveTo evaluate plasma biomarkers for identifying Aβ positivity and stage of tau accumulation.Design, Setting, and ParticipantsThe cohort study (BioFINDER-2) was a prospective memory-clinic and population-based study. Participants with cognitive concerns were recruited from 2017 to 2022 and divided into a training set (80% of the data) and test set (20%).ExposureBaseline values for plasma phosphorylated tau 181 (p-tau181), p-tau217, p-tau231, N-terminal tau, glial fibrillary acidic protein, and neurofilament light chain.Main Outcomes and MeasuresPerformance to classify participants by Aβ status (defined by Aβ-PET or CSF Aβ42/40) and tau status (tau PET). Number of hypothetically saved PET scans in a plasma biomarker–guided workflow.ResultsOf a total 912 participants, there were 499 males (54.7%) and 413 females (45.3%), and the mean (SD) age was 71.1 (8.49) years. Among the biomarkers, plasma p-tau217 was most strongly associated with Aβ positivity (test-set area under the receiver operating characteristic curve [AUC] = 0.94; 95% CI, 0.90-0.97). A 2–cut-point procedure was evaluated, where only participants with ambiguous plasma p-tau217 values (17.1% of the participants in the test set) underwent CSF or PET to assign definitive Aβ status. This procedure had an overall sensitivity of 0.94 (95% CI, 0.90-0.98) and a specificity of 0.86 (95% CI, 0.77-0.95). Next, plasma biomarkers were used to differentiate low-intermediate vs high tau-PET load among Aβ-positive participants. Plasma p-tau217 again performed best, with the test AUC = 0.92 (95% CI, 0.86-0.97), without significant improvement when adding any of the other plasma biomarkers. At a false-negative rate less than 10%, the use of plasma p-tau217 could avoid 56.9% of tau-PET scans needed to identify high tau PET among Aβ-positive participants. The results were validated in an independent cohort (n = 118).Conclusions and RelevanceThis study found that algorithms using plasma p-tau217 can accurately identify most Aβ-positive individuals, including those likely to have a high tau load who would require confirmatory tau-PET imaging. Plasma p-tau217 measurements may substantially reduce the number of invasive and costly confirmatory tests required to identify individuals who would likely benefit from antiamyloid therapies.
Blood Pressure at Different Life Stages Over the Early Life Course and Intima-Media Thickness
Authors: Meng Yaxing , Sharman James E. , Koskinen Juhani S. , Juonala Markus , Viikari Jorma S. A. , Buscot Marie-Jeanne , Wu Feitong , Fraser Brooklyn J. , Rovio Suvi P. , Kähönen Mika , Rönnemaa Tapani , Jula Antti , Niinikoski Harri , Raitakari Olli T. , Pahkala Katja , Magnussen Costan G. 
Published: December 2023

ImportanceAlthough cardiovascular disease (CVD) begins in early life, the extent to which blood pressure (BP) at different life stages contributes to CVD is unclear.ObjectiveTo determine the relative contribution of BP at different life stages across the early-life course from infancy to young adulthood with carotid intima-media thickness (IMT).Design, setting, and participantsThe analyses were performed in 2022 using data gathered from July 1989 through January 2018 within the Special Turku Coronary Risk Factor Intervention Project, a randomized, infancy-onset cohort of 534 participants coupled with annual BP (from age 7 months to 20 years), biennial IMT measurements (from ages 13 to 19 years), who were followed up with again at age 26 years.ExposuresBP measured from infancy (aged 7 to 13 months), preschool (2 to 5 years), childhood (6 to 12 years), adolescence (13 to 17 years), and young adulthood (18 to 26 years).Main outcomes and measuresPrimary outcomes were carotid IMT measured in young adulthood at age 26 years. Bayesian relevant life-course exposure models assessed the relative contribution of BP at each life stage.ResultsSystolic BP at each life stage contributed to the association with young adulthood carotid IMT (infancy: relative weight, 25.3%; 95% credible interval [CrI], 3.6-45.8; preschool childhood: relative weight, 27.0%; 95% CrI, 3.3-57.1; childhood: relative weight, 18.0%; 95% CrI, 0.5-40.0; adolescence: relative weight, 13.5%; 95% CrI, 0.4-37.1; and young adulthood: relative weight, 16.2%; 95% CrI, 1.6-46.1). A 1-SD (at single life-stage) higher systolic BP accumulated across the life course was associated with a higher carotid IMT (0.02 mm; 95% CrI, 0.01-0.03). The findings for carotid IMT were replicated in the Cardiovascular Risk in Young Finns Study that assessed systolic BP from childhood and carotid IMT in adulthood (33 to 45 years).Conclusion and relevanceIn this cohort study, a life-course approach indicated that accumulation of risk exposure to BP levels at all life stages contributed to adulthood carotid IMT. Of those, the contribution attributed to each observed life stage was approximately equal. These results support prevention efforts that achieve and maintain normal BP levels across the life course, starting in infancy.
Sympathetic Neurotransmitter, VIP, Delays Intervertebral Disc Degeneration via FGF18/FGFR2‐Mediated Activation of Akt Signaling Pathway
Authors: Sun Kaiqiang , Sun Jiuyi , Yan Chen , Sun Jingchuan , Xu Ximing , Shi Jiangang 
Published: December 2023

AbstractNeuromodulation‐related intervertebral disc degeneration (IVDD) is a novel IVDD pattern and are proposed recently. However, the mechanistic basis of neuromodulation and intervertebral disc (IVD) homeostasis remains unclear. Here, this study aimed to investigate the expression of postganglionic sympathetic nerve fiber‐derived vasoactive intestinal peptide (VIP) system in human IVD tissue, and to assess the role of VIP‐related neuromodulation in IVDD. Patient samples and in vitro cell experiments showed that the expression of receptors for VIP is negatively correlated with the severity of IVDD, and the administration of exogenous VIP can ameliorate interleukin 1β‐induced nucleus pulposus (NP) cell apoptosis and inflammation. Further mRNA‐seq analysis revealed that fibroblast growth factor 18‐ (FGF18)‐mediated activation of V‐akt murine thymoma viral oncogene homolog signaling pathway is involved in the protective effects of VIP on inflammation‐induced NP cell degeneration. Further analysis identified VIP via its receptor vasoactive intestinal peptide receptor 2 can directly result in decreased expression of miR‐15a‐5p, which targeted FGF18. Finally, in vivo mice lumbar IVDD model confirmed that focally exogenous administration of VIP can effectively ameliorated the progression of IVDD, as shown by the radiological and histological analysis. In conclusion, these results indicated that sympathetic neurotransmitter, VIP, delayed IVDD via FGF18/FGFR2‐mediated activation of V‐akt murine thymoma viral oncogene homolog signaling pathway, which will broaden the horizon concerning how the neuromodulation correlates with IVDD and shed new light on novel therapeutical alternatives to IVDD.