bluuebunny/crossref_metadata_2025_split huggingface dataset:
Pediatric AKI in the real world: changing outcomes through education and advocacy—a report from the 26th Acute Disease Quality Initiative (ADQI) consensus conference
Authors: Mottes Theresa , Menon Shina , Conroy Andrea , Jetton Jennifer , Dolan Kristin , Arikan Ayse Akcan , Basu Rajit K. , Goldstein Stuart L. , Symons Jordan M. , Alobaidi Rashid , Askenazi David J. , Bagshaw Sean M. , Barhight Matthew , Barreto Erin , Bayrakci Benan , Ray O. N. Bignall , Bjornstad Erica , Brophy Patrick , Charlton Jennifer , Chanchlani Rahul , Conroy Andrea L. , Deep Akash , Devarajan Prasad , Fuhrman Dana , Gist Katja M. , Gorga Stephen M. , Greenberg Jason H. , Hasson Denise , Heydari Emma , Iyengar Arpana , Krawczeski Catherine , Meigs Leslie , Morgan Catherine , Morgan Jolyn , Neumayr Tara , Ricci Zaccaria , Selewski David T. , Soranno Danielle , Stanski Natalja , Starr Michelle , Sutherland Scott M. , Symons Jordan , Tavares Marcelo , Vega Molly , Zappitelli Michael , Ronco Claudio , Mehta Ravindra L. , Kellum John , Ostermann Marlies ,   the ADQI 26 workgroup
Published: November 2023

Abstract
Background
Acute kidney injury (AKI) is independently associated with increased morbidity and mortality across the life course, yet care for AKI remains mostly supportive. Raising awareness of this life-threatening clinical syndrome through education and advocacy efforts is the key to improving patient outcomes. Here, we describe the unique roles education and advocacy play in the care of children with AKI, discuss the importance of customizing educational outreach efforts to individual groups and contexts, and highlight the opportunities created through innovations and partnerships to optimize lifelong health outcomes.

Methods
During the 26th Acute Disease Quality Initiative (ADQI) consensus conference, a multidisciplinary group of experts discussed the evidence and used a modified Delphi process to achieve consensus on recommendations on AKI research, education, practice, and advocacy in children.

Results
The consensus statements developed in response to three critical questions about the role of education and advocacy in pediatric AKI care are presented here along with a summary of available evidence and recommendations for both clinical care and research.

Conclusions
These consensus statements emphasize that high-quality care for patients with AKI begins in the community with education and awareness campaigns to identify those at risk for AKI. Education is the key across all healthcare and non-healthcare settings to enhance early diagnosis and develop mitigation strategies, thereby improving outcomes for children with AKI. Strong advocacy efforts are essential for implementing these programs and building critical collaborations across all stakeholders and settings.
Prevalence of unmet supportive care needs reported by individuals ever diagnosed with cancer in Australia: a systematic review to support service prioritisation
Authors: Roseleur Jackie , Edney Laura Catherine , Jung Jayda , Karnon Jonathan 
Published: November 2023

Abstract
Purpose
Improved health outcomes for individuals ever diagnosed with cancer require comprehensive, coordinated care that addresses their supportive care needs. Implementing interventions to address these is confounded by a lack of evidence on population needs and a large pool of potential interventions. This systematic review estimates the point prevalence of different supportive care needs stratified by the tool used to measure needs and cancer type in Australia.

Methods
We searched MEDLINE, Embase, and Scopus from 2010 to April 2023 to identify relevant studies published on the prevalence of supportive care needs in Australia.

Results
We identified 35 studies that met the inclusion criteria. The highest prevalent unmet need across all cancers was ‘fear of cancer spreading’ (20.7%) from the Supportive Care Needs Survey Short-Form 34 (SCNS-SF34), ranging from 9.4% for individuals ever diagnosed with haematological cancer to 36.3% for individuals ever diagnosed with gynaecological cancer, and ‘concerns about cancer coming back’ (17.9%) from the Cancer Survivors’ Unmet Needs (CaSUN), ranging from 9.7% for individuals ever diagnosed with prostate cancer to 37.8% for individuals ever diagnosed with breast cancer. Two studies assessed needs in Aboriginal and Torres Strait Islander populations, reporting the highest needs for financial worries (21.1%).

Conclusions
Point prevalence estimates presented here, combined with estimates of the costs and effects of potential interventions, can be used within economic evaluations to inform evidence-based local service provision to address the supportive care needs of individuals ever diagnosed with cancer.

Implications for Cancer Survivors
Local health services can use local evidence to prioritise the implementation of interventions targeted at unmet needs.
Fairness as a Service (FaaS): verifiable and privacy-preserving fairness auditing of machine learning systems
Authors: Toreini Ehsan , Mehrnezhad Maryam , van Moorsel Aad 
Published: November 2023

AbstractProviding trust in machine learning (ML) systems and their fairness is a socio-technical challenge, and while the use of ML continues to rise, there is lack of adequate processes and governance practices to assure their fairness. In this paper, we propose FaaS, a novel privacy-preserving, end-to-end verifiable solution, that audits the algorithmic fairness of ML systems. FaaS offers several features, which are absent from previous designs. The FAAS protocol is model-agnostic and independent of specific fairness metrics and can be utilised as a service by multiple stakeholders. FAAS uses zero knowledge proofs to assure the well-formedness of the cryptograms and provenance in the steps of the protocol. We implement a proof of concept of the FaaS architecture and protocol using off-the-shelf hardware, software, and datasets and run experiments to demonstrate its practical feasibility and to analyse its performance and scalability. Our experiments confirm that our proposed protocol is scalable to large-scale auditing scenarios (e.g. over 1000 participants) and secure against various attack vectors.
P2 X 7 receptor is a critical regulator of extracellular ATP-induced profibrotic genes expression in rat kidney: implication of transforming growth factor-β/Smad signaling pathway
Authors: Mounieb Fatma , Abdel-Sattar Somaia A , Balah Amany , Akool El-Sayed 
Published: November 2023

AbstractThis study was designed to investigate the potential of extracellular adenosine 5′-triphosphate (ATP) via the P2 X 7 receptor to activate the renal fibrotic processes in rats. The present study demonstrates that administration of ATP rapidly activated transforming growth factor-β (TGF-β) to induce phosphorylation of Smad-2/3. Renal connective tissue growth factor (CTGF) and tissue inhibitor of metalloproteinase-1 (TIMP-1) mRNA and protein expressions were also increased following ATP administration. A decrease in TGF-β amount in serum as well as renal Smad-2/3 phosphorylation was noticed in animals pre-treated with the specific antagonist of P2 X 7 receptor, A 438,079. In addition, a significant reduction in mRNA and protein expression of CTGF and TIMP-1were also observed in the kidneys of those animals. Collectively, the current findings demonstrate that ATP has the ability to augment TGF-β-mediated Smad-2/3 phosphorylation and enhance the expression of the pro-fibrotic genes, CTGF and TIMP-1, an effect that is largely mediated via P2 X 7 receptor.
Strukturierte Kommunikation als Modus agiler Organisation: Eine Fallstudie zu Gruppenprozessen und Lernen bei einem Finanzdienstleister
Authors: Dick Michael , Kasseck Saskia , Scholz Charlotte , Modrzynski Dominik , Bechstein Jan 
Published: November 2023

ZusammenfassungDie in der Zeitschrift „Gruppe. Interaktion. Organisation (GIO)“ erschienene Fallbeschreibung zeigt auf, wie strukturierte Feedbackprozesse in Teams eine fachliche und persönliche Weiterentwicklung ermöglichen. Dazu werden die Arbeitsweisen und Teamprozesse eines Start-up-Unternehmens, das IT-basierte Finanzdienstleistungen anbietet, betrachtet. Diese in der Praxis herausgebildeten und stetig weiterentwickelten Formate werden empirisch rekonstruiert und mit dem „Agile Framework“ verglichen. Es zeigt sich, dass diese Praktiken den Grundsätzen agilen Arbeitens entsprechen und Bedingungen für ein Lernen im Arbeitsprozess, den Aufbau von Wissen und eine flexible und anpassungsfähige Organisation gewährleisten. Abschließend wird diskutiert, wie Führung und Organisationen vor diesem Hintergrund die gegensätzlichen Anforderungen an Stabilität und Agilität austarieren können.
Symptomatic and preventive medication use according to age and frailty in Australian and Japanese nursing homes
Authors: Liau Shin J. , Hamada Shota , Jadczak Agathe D. , Sakata Nobuo , Lalic Samanta , Tsuchiya-Ito Rumiko , Taguchi Reina , Visvanathan Renuka , Bell J. Simon 
Published: November 2023

Abstract
Objective
To investigate symptomatic and preventive medication use according to age and frailty in Australian and Japanese nursing homes (NHs).

Methods
Secondary cross-sectional analyses of two prospective cohort studies involving 12 Australian NHs and four Japanese NHs. Frailty was measured using the FRAIL-NH scale (non-frail 0–2; frail 3–6; most-frail 7–14). Regular medications were classified as symptomatic or preventive based on published lists and expert consensus. Descriptive statistics were used to compare the prevalence and ratio of symptomatic to preventive medications.

Results
Overall, 550 Australian residents (87.7 ± 7.3 years; 73.3% females) and 333 Japanese residents (86.5 ± 7.0 years; 73.3% females) were included. Australian residents used a higher mean number of medications than Japanese residents (9.8 ± 4.0 vs 7.7 ± 3.7, p < 0.0001). Australian residents used more preventive than symptomatic medications (5.5 ± 2.5 vs 4.3 ± 2.6, p < 0.0001), while Japanese residents used more symptomatic than preventive medications (4.7 ± 2.6 vs 3.0 ± 2.2, p < 0.0001). In Australia, symptomatic medications were more prevalent with increasing frailty (non-frail 3.4 ± 2.6; frail 4.0 ± 2.6; most-frail 4.8 ± 2.6, p < 0.0001) but less prevalent with age (< 80 years 5.0 ± 2.9; 80–89 years 4.4 ± 2.6; ≥ 90 years 3.9 ± 2.5, p = 0.0042); while preventive medications remained similar across age and frailty groups. In Japan, there was no significant difference in the mean number of symptomatic and preventive medications irrespective of age and frailty.

Conclusions
The ratio of symptomatic to preventive medications was higher with increasing frailty but lower with age in Australia; whereas in Japan, the ratio remained consistent across age and frailty groups. Preventive medications remained prevalent in most-frail residents in both cohorts, albeit at lower levels in Japan.
John Colet’s Opus de sacramentis and Clerical Anticlericalism: The Limitations of “Ordinary Wayes”
Authors: Kaufman Peter Iver 
Published: November 2023

“I wilnot give my dogge that bred that some prestes doth minister at the Alter when thei be not in clene lyff.” (statement attributed to Elisabeth Sampson, 1509)How subversively anticlerical was late medieval Catholic reform in England? Were Elisabeth Sampson or perhaps John Wyclif the reformer or malcontent at hand, one might expect scholars rapidly to identify reform with subversion. But if John Colet's name is dropped in the conversation, “reform” will generally take on a different meaning. Son of one of London's most popular mayors, Colet was a pluralist who progressed along the familiar and painstakingly protracted route to the doctorate of theology during the final decade of the fifteenth and the first of the sixteenth century. Along the way he struck up close and lasting friendships with Erasmus, Thomas More, and William Warham. To the last of these, he probably owed his appointment in 1504 as Dean of St. Paul's Cathedral in London where he served until his death in 1519.
A new needle nematode, Longidorus zanjanensis sp. nov. (Nematoda: Longidoridae) from north-western Iran
Authors: Asgari M. , Eskandari A. , Castillo P. , Palomares-Rius J.E. 
Published: November 2023

Abstract
During a survey of soil nematodes in 2022, a new species of the genus Longidorus, described here as Longidorus zanjanensis sp. nov., was discovered in the rhizosphere of Astragalus sp. in Zanjan Province, Iran. The new needle nematode is described and illustrated based on morphological, morphometric, and molecular traits. Further, its females are characterized by having a long body ranging 5.6–7.7 mm long, lip region anteriorly flattened and almost continuous or slightly offset by a depression with body contour, ca 16.5–18.5 μm wide, amphidial fovea pouch-like without basal lobes, guiding ring at 35–41 μm distance from the anterior end, and an odontostyle and odontophore ranging 102–115 and 47–75 μm long, respectively. The pharyngeal bulb is 123–153 μm long, female reproductive system didelphic–amphidelphic containing sperm, vulva almost equatorial, located at 46.7–51.4% of body length, tail short, rounded to bluntly conoid, bearing two pairs of caudal pores and terminus widely rounded with distinct radial lines in hyaline region (39–50 μm long, c = 122.4–189.4, c’ = 0.6–0.8). Males are common, making up to 60% of the adults, and are functional, with spicules 68.0–80.0 μm long, as well as having 8–14 ventromedian copulatory supplements. All four juvenile life developmental stages were present, with the tail of first-stage juvenile conoid shape, dorso-ventrally curved with rounded terminus. The polytomous codes delimiting the new species are: A4-B3-C3-D3-E1-F34-G12-H1-I2-J1-K6. Morphologically, the new species comes close to eight known species of the genus, namely L. apulus, L. armeniacae, L. crassus, L. kheirii, L. soosanae, L. proximus, L. pauli, and L. ferrisi. The morphological differences between the new species and the aforementioned species are discussed. Molecular phylogenetic analyses based on D2-D3 of large subunit (LSU) and internal transcribed spacer 1 (ITS1) rRNA sequences indicate that Longidorus zanjanensis sp. nov. is closely related to L. hyrcanus, L. soosanae, and L. elongatus.
Voiced aspirates with mixed voicing in Yemba, a Grassfields Bantu language of Cameroon
Authors: Faytak Matthew , Steffman Jeremy 
Published: November 2023

AbstractUsing electroglottography and acoustic measures, we characterize the strength and quality of voicing in voiced aspirated and unaspirated consonants (stops, fricatives, and approximants) in Yemba (Grassfields Bantu, Cameroon). We show that the Yemba voiced aspirates exhibit mixed voicing: modal voicing during the consonant constriction, but voiceless aspiration after release. Breathy or whispery phonation extends slightly into consonant constrictions preceding, and across the entire duration of vowels following, aspiration; this non-modal phonation extends further into prenasalized consonants. Mixed voicing has typically been excluded from the possible range of laryngeal–supralaryngeal coordinative patterns in consonants, and is thought to be unattested in the world’s languages; most previous work on this topic assumes that non-modal phonation after voiced consonant release is breathy-voiced. However, we argue that Yemba voiced aspirates differ from more commonly studied breathy-release aspirates only in the settings of some gestural parameters: the late glottal spread gesture is larger in magnitude and more resistant to coarticulation, yielding consistently devoiced aspiration which may even be more perceptually recoverable compared to breathiness.
Evaluating preschool linear growth velocities: an interim reference illustrated in Nepal
Authors: Manohar Swetha , Colantuoni Elizabeth , Thorne-Lyman Andrew Lucian , Shrestha Binod , Adhikari Ramesh Kant , KC Angela , Bhattarai Abhigyna , West Keith Parker 
Published: November 2023

AbstractObjective:An annualised linear growth velocity (LGV) reference can identify groups of children at risk of growing poorly. As a single velocity reference for all preschool ages does not exist, we present an interim tool, derived from published, normative growth studies, for detecting growth faltering, illustrating its use in Nepali preschoolers.Design:The WHO Child Growth Velocity Standard was adapted to derive 12-month increments and conjoined to the Tanner-Whitehouse Height Velocity Reference data yielding contiguous preschool linear growth annualised velocities. Linear restricted cubic spline regressions were fit to generate sex-specific median and standard normal deviate velocities for ages 0 through 59 months. LGV Z-scores (LGVZ) were constructed, and growth faltering was defined as LGVZ < –2.Setting:Use of the reference was illustrated with data from Nepal’s Tarai region.Participants:Children contributing the existing growth references and a cohort of 4276 Nepali children assessed from 2013 to 2016.Results:Fitted, smoothed LGV reference curves displayed monotonically decreasing 12-month LGV, exemplified by male/female annual medians of 26·4/25·3, 12·1/12·7, 9·1/9·4, 7·7/7·8 and 7/7 cm/years, starting at 0, 12, 24, 36 and 48 months, respectively. Applying the referent, 31·1 %, 28·6 % and 29·3 % of Nepali children <6, 6–11 and 12–23 months of age, and ∼6 % of children 24–59 months, exhibited growth faltering. Under 24 months, faltering velocities were more prevalent in girls (34·4 %) than boys (25·3 %) (P < 0·05) but comparable (∼6 %) in older preschoolers.Conclusions:A LGV reference, concatenated from extant data, can identify preschool groups at-risk of growth faltering. Application and limitations are discussed.
Addressing equality, diversity and inclusion as part of CBT training: a course evaluation study
Authors: Presley Vickie L. 
Published: November 2023

Abstract
It is widely documented that Black, Asian and Minority Ethnic (BAME) communities experience poorer mental health, and have a poorer experience of mental health services. Therapists delivering cognitive behavioural therapy (CBT) in services such as NHS Talking Therapies Services for Anxiety and Depression, are working with increasingly diverse client groups, but treatment access and recovery rates remain below what they should be compared with the White British population. Previous research indicates that CBT therapists may not receive appropriate training that allows them to develop the skills required to work effectively transculturally. The present study therefore aimed to evaluate a CBT training programme within this context, from the perspective of previous course graduates. Thirty participants took part in an online survey with questions requiring both Likert-scaled answers and free-text responses. Descriptive statistics, inferential statistics and template analysis were used to analyse the data. The results of the survey were favourable overall for both White British and BAME respondents. Positive areas of practice highlighted included peer learning within a diverse cohort, building awareness of own biases, and reflective learning spaces. Areas of development included increased integration of teaching focused on adapting CBT models for minority groups, diversification of teaching staff, and reducing fear and avoidance of exploring issues related to equality, diversity and inclusion. Tentative implications for improving CBT training course delivery in this context have been offered.

Key learning aims

(1)
To acknowledge the challenges faced by service users from BAME communities in accessing equitable mental health treatment, including cognitive behavioural psychotherapy.

(2)
To consider explanations for why CBT therapists working in NHS services might find it difficult to work effectively transculturally.

(3)
To establish ways in which CBT training programmes might help therapists to embark more successfully on the journey of developing cultural competence, during training and beyond.
Mfap4: a promising target for enhanced liver regeneration and chronic liver disease treatment
Authors: Iakovleva Viktoriia , Wuestefeld Anna , Ong Agnes Bee Leng , Gao Rong , Kaya Neslihan Arife , Lee May Yin , Zhai Weiwei , Tam Wai Leong , Dan Yock Young , Wuestefeld Torsten 
Published: November 2023

AbstractThe liver has a remarkable regenerative capacity. Nevertheless, under chronic liver-damaging conditions, this capacity becomes exhausted, allowing the accumulation of fibrotic tissue and leading to end-stage liver disease. Enhancing the endogenous regenerative capacity by targeting regeneration breaks is an innovative therapeutic approach. We set up an in vivo functional genetic screen to identify such regeneration breaks. As the top hit, we identified Microfibril associated protein 4 (Mfap4). Knockdown of Mfap4 in hepatocytes enhances cell proliferation, accelerates liver regeneration, and attenuates chronic liver disease by reducing liver fibrosis. Targeting Mfap4 modulates several liver regeneration-related pathways including mTOR. Our research opens the way to siRNA-based therapeutics to enhance hepatocyte-based liver regeneration.
Dentinomimetics and cementomimetics of Moringa oleifera leaves extract
Authors: Obeid Raneem F. , Ammar Mohamed M. , Younis Sara H. 
Published: November 2023

AbstractTo evaluate the biomimetic remineralization capabilities of Moringa oleifera leaves (MOL) extract on coronal dentin and acellular cementum, two different concentrations (50 and 200 mg/ml) of MOL extract loaded in plain varnish (M1 and M2 groups respectively) were compared to fluoride varnish (FL group) and native surface (C group). Eighty sound premolar teeth were collected. Forty teeth (10 teeth in each group) were used for coronal dentin testing while the other forty (10 teeth in each group) were used for acellular cementum testing. Teeth in M1, M2, and FL groups were etched for 30 s and then received the specific varnish treatment. All samples were immersed in artificial saliva for 14 days and then collected, dried, and examined by scanning electron microscopy and energy dispersive X-ray spectroscopy (EDX). Histologically, FL group showed mineral deposition as discrete vesicular granules of various sizes on the surface of both coronal dentin and acellular cementum. Mineral deposition only occurred on some DTs openings while opened tubules remained. The surface of the acellular cementum revealed regular grooves, micro-fissures, and cracks. In the M1 and M2 groups, mineral deposition appeared as a homogenous continuous layer on coronal dentin and acellular cementum. Only a few DTs and cementum fissures were not filled completely. In L.S. sections of the coronal one-third, the DTs appeared almost sealed with varying lengths of mineral deposition. EDX results statistical analysis showed that the M2 group had the highest phosphate ions (P−) and calcium ions (Ca+2) at%. MOL has an extraordinary effect on the remineralization of coronal dentin and acellular cementum. It would have a promising ability to control dentinal hypersensitivity and formation of biomimetic cementum tissue.
Radiotracers in the Diagnosis of Pain: A Mini Review
Authors: Hascalovici Jacob , Babb Anthony , Norwood Braxton A. 
Published: November 2023

AbstractThe diagnosis and understanding of pain is challenging in clinical practice. Assessing pain relies heavily on self-reporting by patients, rendering it inherently subjective. Traditional clinical imaging methods such as computed tomography and magnetic resonance imaging can only detect anatomical abnormalities, offering limited sensitivity and specificity in identifying pain-causing conditions. Radiotracers play a vital role in molecular imaging that aims to identify abnormal biological processes at the cellular level, even in apparently normal anatomical structures. Therefore, molecular imaging is an important area of research as a prospective diagnostic modality for pain-causing pathophysiology. We present a mini review of the current knowledge base regarding radiotracers for identification of pain in vivo. We also describe radiocaine, a novel positron emission tomography imaging agent for sodium channels that has shown great potential for identifying/labeling pain-producing nerves and producing an objectively measurable pain intensity signal.