bluuebunny/crossref_metadata_2025_split huggingface dataset:
Development and Validation of a Prediction Model of Outcome After B-Cell Maturation Antigen-Directed Chimeric Antigen Receptor T-Cell Therapy in Relapsed/Refractory Multiple Myeloma
Authors: Gagelmann Nico , Dima Danai , Merz Maximilian , Hashmi Hamza , Ahmed Nausheen , Tovar Natalia , Oliver-Caldés Aina , Stölzel Friedrich , Rathje Kristin , Fischer Luise , Born Patrick , Schäfer Lisa , Albici Anca-Maria , Schub Natalie , Kfir-Erenfeld Shlomit , Assayag Miri , Asherie Nathalie , Wulf Gerald Georg , Kharboutli Soraya , Müller Fabian , Shune Leyla , Davis James A. , Anwer Faiz , Vucinic Vladan , Platzbecker Uwe , Ayuk Francis , Kröger Nicolaus , Khouri Jack , Gurnari Carmelo , McGuirk Joseph , Stepensky Polina , Abdallah Al-Ola , Fernández de Larrea Carlos 
Published: February 2024

PURPOSE Although chimeric antigen receptor T therapy (CAR-T) cells are an established therapy for relapsed/refractory multiple myeloma (RRMM), there are no established models predicting outcome to identify patients who may benefit the most from CAR-T. PATIENTS AND METHODS This is an international retrospective observational study including patients with RRMM infused with currently available commercial or academically produced anti–B-cell maturation antigen (BCMA) CAR-T. We describe characteristics and outcomes in Europe (n = 136) and the United States (n = 133). Independent predictors of relapse/progression built a simple prediction model (Myeloma CAR-T Relapse [MyCARe] model) in the training cohort (Europe), which was externally validated (US cohort) and tested within patient- and treatment-specific subgroups. RESULTS The overall response rate was 87% and comparable between both cohorts, and complete responses were seen in 48% (Europe) and 49% (the United States). The median time to relapse was 5 months, and early relapse <5 months from infusion showed poor survival across cohorts, with the 12-month overall survival of 30% (Europe) and 14% (the United States). The presence of extramedullary disease or plasma cell leukemia, lenalidomide-refractoriness, high-risk cytogenetics, and increased ferritin at the time of lymphodepletion were independent predictors of early relapse or progression. Each factor received one point, forming the three-tiered MyCARe model: scores 0-1 (low risk), scores 2-3 (intermediate risk), and a score of 4 (high risk). The MyCARe model was significantly associated with distinct 5-month incidence of relapse/progression ( P < .001): 7% for low-risk, 27% for intermediate-risk, and 53% for high-risk groups. The model was validated in the US cohort and maintained prognostic utility for response, survival, and outcomes across subgroups. CONCLUSION Outcomes of patients with RRMM after CAR-T are comparable between Europe and the United States. The MyCARe model may facilitate optimal timing of CAR-T cells in patient-specific subgroups.
Spinal Anterior Dural Dissection: Moving From Differential to Unifying Diagnosis
Authors: Knafo Steven , Herbrecht Anne , Cauquil Cécile , Sarov Mariana , Not Adeline , Ancelet Claire , Nasser Ghaida , Benhamou Dan , Oillic Pierre-Antoine , Guey Stéphanie , Lenglet Timothée , Parker Fabrice , Aghakhani Nozar 
Published: February 2024

BACKGROUND AND OBJECTIVES:
Cerebrospinal fluid (CSF) collections extending longitudinally at the anterior aspect of the spinal dura have been reported in association with various conditions and under multiple names. The aim of this study was to report cases associated with brachial amyotrophy (BA) and examine its relationship with other clinical variants.

METHODS:
We conducted a retrospective cohort study including patients who presented with a motor deficit of the upper limbs and an anterior interdural CSF collection on spinal MRI. We performed a systematic review of the literature to include cases revealed by BA.

RESULTS:
Seven patients presenting with BA and a confirmed dural dissection on spinal MRI were included. All patients were male with a slowly progressing history of asymmetrical and proximal motor deficit of the upper limbs. Chronic denervation affecting mostly C5 and C6 roots was found on electroneuromyography. Spinal MRI demonstrated an anterior CSF collection dissecting the interdural space and exerting a traction on cervical motor roots. Dynamic computed tomography myelogram localized the dural defect every time it was performed (4/7 cases), and surgical closure was possible for 3 patients, leading to resolution of the collection. Literature review yielded 18 other published cases of spinal dural dissections revealed by BA, including 4 in association with spontaneous intracranial hypotension and 4 others in association with superficial siderosis.

CONCLUSION:
We propose a unifying diagnosis termed “spinal anterior dural dissection” (SADD) to encompass spinal dural CSF collections revealed by BA (SADD-BA), spontaneous intracranial hypotension (SADD-SIH), or superficial siderosis (SADD-SS).
Solving Bilevel Programs Based on Lower-Level Mond-Weir Duality
Authors: Li Yu-Wei , Lin Gui-Hua , Zhu Xide 
Published: February 2024

This paper focuses on developing effective algorithms for solving a bilevel program. The most popular approach is to replace the lower-level problem with its Karush-Kuhn-Tucker conditions to generate a mathematical program with complementarity constraints (MPCC). However, MPCC does not satisfy the Mangasarian-Fromovitz constraint qualification (MFCQ) at any feasible point. In this paper, inspired by a recent work using the lower-level Wolfe duality (WDP), we apply the lower-level Mond-Weir duality to present a new reformulation, called MDP, for bilevel program. It is shown that, under mild assumptions, they are equivalent in globally or locally optimal sense. An example is given to show that, different from MPCC, MDP may satisfy the MFCQ at its feasible points. Relations among MDP, WDP, and MPCC are investigated. On this basis, we extend the MDP reformulation to present another new reformulation (called eMDP), which has similar properties to MDP. Furthermore, to compare two new reformulations with the MPCC and WDP approaches, we design a procedure to generate 150 tested problems randomly and comprehensive numerical experiments show that MDP has quite evident advantages over MPCC and WDP in terms of feasibility to the original bilevel programs, success efficiency, and average CPU time, whereas eMDP is far superior to all other three reformulations. History: Accepted by Pascal Van Hentenryck, Area Editor for Computational Modeling: Methods & Analysis. Funding: This work was supported by the National Natural Science Foundation of China [Grants 12071280 and 11901380]. Supplemental Material: The software that supports the findings of this study is available within the paper and its Supplemental Information ( https://pubsonline.informs.org/doi/suppl/10.1287/ijoc.2023.0108 ) as well as from the IJOC GitHub software repository ( https://github.com/INFORMSJoC/2023.0108 ). The complete IJOC Software and Data Repository is available at https://informsjoc.github.io/ .
Submodular Functions and Perfect Graphs
Authors: Abrishami Tara , Chudnovsky Maria , Dibek Cemil , Vušković Kristina 
Published: February 2024

We give a combinatorial polynomial-time algorithm to find a maximum weight independent set in perfect graphs of bounded degree that do not contain a prism or a hole of length four as an induced subgraph. An even pair in a graph is a pair of vertices all induced paths between which are even. An even set is a set of vertices every two of which are an even pair. We show that every perfect graph that does not contain a prism or a hole of length four as an induced subgraph has a balanced separator which is the union of a bounded number of even sets, where the bound depends only on the maximum degree of the graph. This allows us to solve the maximum weight independent set problem using the well-known submodular function minimization algorithm. Funding: This work was supported by the Engineering and Physical Sciences Research Council [Grant EP/V002813/1]; the National Science Foundation [Grants DMS-1763817, DMS-2120644, and DMS-2303251]; and Alexander von Humboldt-Stiftung.
High-speed PGC demodulation model and method with subnanometer displacement resolution in a fiber-optic micro-probe laser interferometer
Authors: Dong Yisi , Li Wenwen , Zhang Jinran , Luo Wenrui , Fu Haijin , Xing Xu , Hu Pengcheng , Dong Yongkang , Tan Jiubin 
Published: February 2024

As the key of embedded displacement measurement, a fiber-optic micro-probe laser interferometer (FMI) is of great interest in developing high-end equipment as well as precision metrology. However, conventional phase-generated carrier (PGC) approaches are for low-speed scenes and local error analysis, usually neglecting the global precision analysis and dynamic effect of system parameters under high-speed measurement, thus hindering their broad applications. We present a high-speed PGC demodulation model and method to achieve subnanometer displacement measurement precision in FMI. This model includes a global equivalent resolution analysis and revelation of the demodulation error mechanism. Utilizing this model, the failure issues regarding the PGC demodulation method under high speed and large range are addressed. Furthermore, an ultra-precision PGC demodulation algorithm based on the combination of static and dynamic delay adaptive regulation is proposed to enable high-speed and large-range displacement measurement. In this paper, the proposed model and algorithm are validated through simulation and experimental tests. The results demonstrate a displacement resolution of 0.1 nm with a standard deviation of less than 0.5 nm when measuring at a high velocity of 1.5 m/s—nearly a tenfold increase of the latest study.
Strong light–matter interactions based on excitons and the abnormal all-dielectric anapole mode with both large field enhancement and low loss
Authors: Deng Yan-Hui , Lu Yu-Wei , Zhang Hou-Jiao , Shi Zhong-Hong , Zhou Zhang-Kai , Wang Xue-Hua 
Published: February 2024

The room temperature strong coupling between the photonic modes of micro/nanocavities and quantum emitters (QEs) can bring about promising advantages for fundamental and applied physics. Improving the electric fields (EFs) by using plasmonic modes and reducing their losses by applying dielectric nanocavities are widely employed approaches to achieve room temperature strong coupling. However, ideal photonic modes with both large EFs and low loss have been lacking. Herein, we propose the abnormal anapole mode (AAM), showing both a strong EF enhancement of ∼70-fold (comparable to plasmonic modes) and a low loss of 34 meV, which is much smaller than previous records of isolated all-dielectric nanocavities. Besides realizing strong coupling, we further show that by replacing the normal anapole mode with the AAM, the lasing threshold of the AAM-coupled QEs can be reduced by one order of magnitude, implying a vital step toward on-chip integration of nanophotonic devices.
Challenges of proper disposal of old long-lasting insecticidal nets and its alternative uses in rural south-eastern Tanzania
Authors: Msangi Sheila J. , Mponzi Winifrida P. , Muyaga Letus L. , Nkya Joel D. , Mwalugelo Yohana A. , Msuya Hajirani M. , Lwetoijera Dickson W. , Kaindoa Emmanuel W. 
Published: February 2024

Introduction
Insecticide-treated nets (ITNs), specifically long-lasting insecticidal nets (LLINs), are the most commonly used, scalable, and cost-effective tools for controlling malaria transmission in sub-Saharan Africa. However, the multiple alternative uses of retired LLINs have been associated with poor disposal practices. The World Health Organization (WHO) has provided guidelines and recommendations for the proper management of worn-out LLINs. This study assessed the existing alternative uses and disposal practices of old LLINs.

Methods
An explanatory sequential mixed-methods approach was used to assess LLINs existing alternative uses, disposal practices, knowledge, and perceptions regarding WHO recommendations on proper disposal of old LLINs among stakeholders in Kilombero and Ulanga districts, south-eastern Tanzania. A survey questionnaire was administered to 384 participants. Furthermore, the study employed focus group discussions (FGD) and key informant interviews (KII) to elucidate responses regarding existing disposal practices, associated challenges, and alternative uses of LLINs. The insights derived from both study components were subsequently used for inferential analysis.

Results
The major challenge influencing the proper disposal of LLINs was limited awareness of how to properly dispose of them. Of the 384 people surveyed, 97.0% were not aware of the WHO recommendations for the proper disposal of old LLINs. All key informants were unaware of the WHO guidelines for proper disposal of old LLINs. The common methods used to dispose of LLINs were burning (30.7%), disposing them into garbage pits (14.8%), and alternative uses (12.2%). Of the 239 respondents with LLINs, 41.0% had alternative use, while 59.0% had no alternative use. The common alternative uses were ropes for tying or covering items (20.9%), garden fencing (7.5%), chicken coops (5.0%), and 7.5% for other minor alternative uses.

Conclusion
Strengthening awareness and education on proper LLIN disposal practices among community members and key stakeholders is essential for enhancing malaria control efforts and preventing environmental pollution.
Factors influencing gestational diabetes self-care among pregnant women in a Syrian Refugee Camp in Jordan
Authors: Assaf Enas A. , Al Sabbah Haleama , Momani Aaliyah , Al-Amer Rasmieh , A. Al-Sa’ad Ghada , Ababneh Anas 
Published: February 2024

Aim
The main objective of this study is to identify the level of self-care practices and the determinants of Gestational Diabetes Mellitus (GDM) among pregnant women residing in one of the refugee camps in Jordan.

Method
A cross-sectional study was conducted on a convenient sample of forty women diagnosed with GDM from the high-risk maternity clinic in one of the Syrian refugee camps in Jordan. The study used the Gestational Diabetes Management Self-Efficacy Scale (GDMSES), Diabetes Knowledge (DMK) assessment, and Diabetes Self-Care Activities Questionnaire (SDSCA) to measure the variables of interest. Descriptive analysis and Multiple logistic regression were used to assess for significant factors.

Results
Significant associations were found between the subcategories of diet, exercise, and blood sugar control in both the self-efficacy and self-activity scales (p < 0.01, p < 0.01, p < 0.05), respectively. Two factors were associated with higher GDM self-care: diabetes knowledge and higher self-efficacy toward GDM self-care (p < 0.05).

Conclusion
The findings of this study highlight that pregnant women with GDM who have higher levels of self-efficacy and diabetes knowledge are more likely to achieve higher levels of GDM self-care. Beside developing health promotion programs to enhance women’s self-efficacy in adhering to GDM care, adequate support and relevant resources to facilitate GDM management among refugee women are recommended. Future research for identifying other potential factors affecting GDM self-care among refugees is highly recommended.
The seamlessness of grammatical innovation: the case of be going to (revisited)
Authors: Dietrich Nadine 
Published: February 2024

Abstract
In this paper, I revisit the continued debate surrounding manner of grammatical innovation, i.e. whether it is abrupt or gradual. I show that the debate is complicated by different diagnostics for manner and argue that it is best understood in terms of degree of similarity (how similar the innovative use is to existing uses of a construction). However, even when adopting degree of similarity as a diagnostic, approaches differ with regards to how similar they find innovative and existing uses. The gradualness account argues that innovative uses are similar but distinct from existing uses, as they imply a new form-meaning pairing. A seamlessness account instead argues that innovative and existing uses are so similar that no new form-meaning pairing is required. I develop seamlessness into a theoretical position for semantic innovation in grammaticalization, which holds that grammatical innovations are maximally similar to existing uses i.e. they exhibit considerable conceptual overlap and the existing use is semantically underspecified. Seamlessness is empirically tested using semantic innovations in be going to as a case study.
Monitoring of mangrove forests vegetation based on optical versus microwave data: A case study western coast of Saudi Arabia
Authors: Aljahdali Mohammed H. , Adisu Baradin , Adem Esubalew , Chaabani Anis , Boteva Silvena , Zhang Lifu , Elhag Mohamed 
Published: February 2024

Abstract
Normalized difference vegetation index (NDVI) is one of the parameters of vegetation that can be studied by remote sensing of land surface with Sentinel-2 (S-2) satellite image. The NDVI is a nondimensional index that depicts the difference in plant cover reflectivity between visible and near-infrared light and can be used to measure the density of green on a piece of land. On the other hand, the dual-pol radar vegetation index (DpRVI) is one of the indices studied using multispectral synthetic aperture radar (SAR) images. Researchers have identified that SAR images are highly sensitive to identify the buildup of biomass from leaf vegetative growth to the flowering stage. Vegetation biophysical characteristics such as the leaf area index (LAI), vegetation water content, and biomass are frequently used as essential system parameters in remote sensing data assimilation for agricultural production models. In the current study, we have used LAI as a system parameter. The findings of the study revealed that the optical data (NDVI) showed a high correlation (up to 0.712) with LAI and a low root-mean-square error (0.0296) compared to microwave data with 0.4523 root-mean-square error. The NDVI, LAI, and DpRVI mean values all decreased between 2019 and 2020. While the DpRVI continued to decline between 2020 and 2021, the NDVI and LAI saw an increase over the same period, which was likely caused by an increase in the study area’s average annual rainfall and the cautious stance of the Red Global (RSG) project on sustainability.
Room temperature polaritonic soft-spin XY Hamiltonian in organic–inorganic halide perovskites
Authors: Peng Kai , Li Wei , Berloff Natalia G. , Zhang Xiang , Bao Wei 
Published: February 2024

Abstract
Exciton–polariton condensates, due to their nonlinear and coherent characteristics, have been employed to construct spin Hamiltonian lattices for potentially studying spin glass, critical dephasing, and even solving optimization problems. Here, we report the room-temperature polariton condensation and polaritonic soft-spin XY Hamiltonian lattices in an organic–inorganic halide perovskite microcavity. This is achieved through the direct integration of high-quality single-crystal samples within the cavity. The ferromagnetic and antiferromagnetic couplings in both one- and two-dimensional condensate lattices have been observed clearly. Our work shows a nonlinear organic–inorganic hybrid perovskite platform for future investigations as polariton simulators.
Transport of radioactive materials from terrestrial to marine environments in Fukushima over the past decade
Authors: Fan Shaoyan , Nasu Koki , Takeuchi Yukio , Fukuda Miho , Arai Hirotsugu , Taniguchi Keisuke , Onda Yuichi 
Published: February 2024

Abstract
While 20 % of radionuclides released from the Fukushima Daiichi Nuclear Power Plant accident had been deposited in the terrestrial environment, rivers remain the long-term source for 137Cs, primarily through particulate transfer, from terrestrial to marine ecosystems. In this study, we estimated the suspended 137Cs flux to the ocean at 11 sites in the coastal area between October 2012 and December 2020 to be 17 TBq, based on our long-term monitoring data of concentrations of suspended 137Cs and suspended solids. The cumulative loss of suspended 137Cs from each site to the ocean ranged from 0.1 % to 1.7 % of initial deposition throughout the observation period, depending on the effect of dam lakes and normalized river discharge. The higher loss is also thought to be the large outflow of runoff during the typhoon. The current level of the suspended 137Cs concentrations was lowered to 1/10–1/100 of those immediately after the accident. The average value of the decreasing trend for each site was approximated using the equation: y = a1 e −k
1
t + a2 e −k
2t. The rate constant k
1 is higher in areas with intensive land use, such as pastures, bare land, and water surfaces, and k
2 is lower in urban areas.
Greenness of dispersive microextraction using molecularly imprinted polymers
Authors: Tadić Tamara , Marković Bojana , Bulatović Sandra , Lukić Jelena , Radulović Jelena , Nastasović Aleksandra , Onjia Antonije 
Published: February 2024

Abstract
Molecularly imprinted polymers (MIPs) as materials with determined levels of selectivity and specificity for designated analytes have recently gained much attention in various application fields. However, with the growing adoption of green analytical chemistry (GAC) principles, it is essential to investigate the greenness of MIP synthesis and its subsequent application in sample preparation, as well as to evaluate the “green” nature of the developed analytical methodologies, such as dispersive solid-phase microextraction (DSPME). Accordingly, the main objective of this research was to evaluate the greenness of MIP-based glycidyl methacrylate synthesis and MIP use as a DSPME sorbent prior to high-performance liquid chromatography with mass spectrometry (HPLC-MS). The green perspective of MIP-DSPME prior to HPLC-MS was investigated using various analytical metric tools such as the Analytical Eco-Scale, the Green Analytical Procedure Index, and Analytical GREEnness (AGREE). Since these analytical tools are not fully implementable for the assessment of the greenness of the MIP synthesis, some alternative approaches were used to optimize the synthesis parameters to make the MIP DSPME sorbent as close as possible to the GAC principles. The calculated AGREE score (0.62) and 91 points in the Analytical Eco-Scale for the proposed DSPME technique using MIP indicated a high level of greenness.
Unveiling the multifaceted roles of protonated 1,2-bis(4-pyridyl)ethylene (HBpe+) ligand in metal-driven supramolecular assembly: a comprehensive structural review
Authors: Singha Debabrata , Datta Pritha , Halder Sasthi Charan , Jana Atish Dipankar , Pal Nilasish 
Published: February 2024

Abstract
A protonated form of 1,2-bis(4-pyridyl)ethylene (HBpe+), produced through proton transfer or pH adjustments, plays a significant role in forming unique supramolecular structures. In contrast, non-protonated forms of the molecule (Bpe) are extensively studied in metal-organic complexes. In this review, we examine the fascinating world of HBpe+ as a monodentate ligand in the realm of coordination chemistry. It discusses how protonated ligands influence the assembly of supramolecular structures, as well as their properties and functions. Structures such as 1:1 adduct, coordination polymers, and metal clusters are often formed as a result. In these assemblies, HBpe+ engages in a variety of interactions that influence its supramolecular behavior. The interactions include coordination complexes with metal ions, hydrogen bonds, aromatic ring stacking, and double bond stacking (π⋯π stacking). The flexibility and conformation of the ligand have a significant impact on the overall structure and stability of complexes. It opens the door to developing functional materials by unraveling the unique attributes and role of HBpe+ in supramolecular assembly. With these insights, it is possible to explore the functional properties of HBpe+ through controlled assembly processes in order to create innovative and functional materials.