bluuebunny/crossref_metadata_2025_split huggingface dataset:
Acid‐Triggered Dual‐Functional Hydrogel Platform for Enhanced Bone Regeneration
Authors: Xiao Yao , Ma Jinjin , Yuan Xiaonan , Wang Huan , Ma Fengyu , Wu Jun , Chen Qianglong , Hu Jie , Wang Lijie , Zhang Zhendong , Wang Chao , Li Jiaying , Wang Weishan , Li Bin 
Published: January 2025

AbstractStem cell implantation holds promise for enhancing bone repair, but risks of pathogen transmission and malignant cell transformation should not be ignored. Compared to stem cell implantation, recruitment of endogenous stem cells to injured sites is more critical for in situ bone regeneration. In this study, based on the acidic microenvironment of bone injury, an HG‐AA1:1‐SDF‐1α composite hydrogel with a dual‐control intelligent switch function is developed by incorporating stromal cell‐derived factor (SDF‐1α), arginine carbon dots (Arg‐CDs), and calcium ions (Ca2+) into the oxidized hyaluronic acid/gelatin methacryloyl (HG) hydrogel. The acidic microenvironment triggers the first switch (Schiff base bond is broken between HG‐AA1:1 and SDF‐1α) of HG‐AA1:1‐SDF‐1α composite hydrogel to continuously release SDF‐1α. Compared to the neutral (pH 7.4) media, the cumulative release of SDF‐1α in acidic (pH 5.5) media is ≈2.5 times higher, which enhances the migration and recruitment of endogenous mesenchymal stem cells (MSCs). The recruited MSCs immediately initiate the second switch and metabolize Arg‐CDs into the bioactive nitric oxide (NO) in the presence of Ca2+, activating NO/cyclic guanosine monophosphate (cGMP) signaling pathway to promote angiogenesis. Therefore, the engineered HG‐AA1:1‐SDF‐1α composite hydrogel shows promising potential to achieve “coupling osteogenesis and angiogenesis” for bone regeneration.
Molecular Nanojunction Catalyst for Oxygen Evolution Reaction
Authors: Wei Kuo , Liu Zhiping , Feng Guangyuan , Wang Yuanzhe , Zhang Shaofang , Li Xiaojuan , Zhang Miao , Li Heen , Zhou Junshuang , Lei Shengbin , Gao Faming 
Published: January 2025

AbstractAchieving close integration and strong electronic communication between molecular catalysts and conductive substrates is crucial for developing the stability and catalytic activity of the nanomaterials. However, constructing molecular heterostructure catalyst usually need complex and demanding synthesis processes. Herein, a facile and universal “molecular nanojunction” strategy is developed to prepare molecular catalysts with high stability and catalytic activity by improving the coplanarity of the molecular nanojunction catalysts and facilitating efficient electron transfer. The density function theory (DFT) calculations and in situ characterization indicate that the molecular nanojunction catalyst reduces excessive *OH adsorption and accelerates the deprotonation process, thereby promoting oxygen generation. The “molecular nanojunction” catalyst shows better oxygen evolution reaction (OER) performance than most reported molecular catalysts. What's more, the molecular nanojunction catalysts are applied in alkaline anion exchange membrane (AEM) electrolysis cells, exhibiting excellent catalytic performance.
Otolith Increments and Elements: Assessing a Recently Discovered Population of Weather Loach
Authors: Amman Brendan R. , Gerrin Wesley L. , McNair Sarah F. , Hazelton Peter D. , Shelton James L. , Shamblin Brian M. , Hamel Martin J. 
Published: January 2025

ABSTRACTThe introduction of aquatic non‐native species into novel systems may have negative impacts on native biodiversity. Introduced species can predate native species, compete for resources, transmit diseases, hybridise and degrade habitat. To minimise impacts on aquatic biota, management efforts are needed to reduce invasive species abundance. However, eradication or reduction efforts require information about the source of introductions and the biology and ecology of the organism. Therefore, the objective of this study was to quantify population dynamics, natal origins and dispersal characteristics of the introduced Weather Loach Misgurnus anguillicaudatus, which was recently discovered in Georgia, USA waters. Sagittal otoliths were extracted and aged to determine dynamic rate functions, and we performed microchemical analysis on a subset of otoliths to quantify dispersal and introduction events. Sampled Weather Loach consisted of a wide range of ages and lengths, indicating that natural reproduction and recruitment have been occurring for multiple years. The change in otolith microchemistry seen in some fish reveals that they have dispersed from their introduction or reproduction sites into different areas, while others have likely remained in the same system since hatching. Overall, our findings indicate that the Weather Loach populations in Georgia are disjunct, likely stemming from multiple introductions. These results will be used to develop management strategies as well as aid in the effort to continue and enhance outreach regarding the release of unwanted aquarium fish.
Current Status of Hilsa (Tenualosa ilisha) Fisheries in Bangladesh and Implications for Future Research and Development
Authors: Alam Md. Mehedi , Haque Mohammad Mahfujul , Santi Morena , Rahman Md. Asadur , Hasan Neaz A. , Mahalder Balaram 
Published: January 2025

ABSTRACTHilsa shad (Tenualosa ilisha) is an anadromous fish, making the single largest wild fishery in Bangladesh, supporting the livelihoods of about 2% of the population and contributing 1% to the national GDP. Several studies reported positive outcomes associated with its catch status, biology, ecology, nutritional profile, conservation and management and socio‐economic impacts. However, significant knowledge gaps exist in hilsa fisheries, particularly in the areas crucial for research and development. In this article, we conducted a systematic review of literature to identify and address the knowledge gaps, challenges and research priorities in hilsa fisheries to ensure their sustainable management and production. Recent data from the Department of Fisheries (DoF) indicate rising production of hilsa in Bangladesh, sparking debate about its accuracy. Reliable data are essential to avoid miscalculations that could lead to risk of overfishing or underfishing of this important fish. Hilsa matures at 6–12 months, lives 2–6 years, feeds primarily on phytoplankton and spawns mostly during full moon of September and October. The abundance of brood hilsa in the river systems before and after the peak breeding season suggests further research is needed to refine breeding period for sustainable production. Although recent molecular studies have mapped the complete genome of hilsa, there remains a lack of comprehensive knowledge on its biology, ecology, conservation and life cycle—the key areas for sustainable catches and domestication. Enhancing global demand for this species requires value addition, such as removing sharp pin bones in the flesh. DoF has implemented various policies and projects, including establishment of sanctuaries to protect and conserve hilsa fisheries for sustainable exploitation. However, these measures have sparked controversy due to their adverse impacts on income and livelihoods of fishermen. Addressing these challenges and knowledge gaps requires focused research and development initiatives to ensure sustainable hilsa fisheries in Bangladesh.
Pharmacogenetic Testing for Predicting Methylphenidate Treatment Outcomes in Childhood Attention Deficit Hyperactivity Disorder in Turkey: Focus on Carboxylesterase 1, Latrophilin‐3, and Catechol‐O‐Methyltransferase
Authors: Suzer Gamli Ipek , Van Veggel Anne , Karaaslan Rabia Sevcan , Kuerec Ajla Hodzic , Marzoukah Zeina , Adak Ibrahim , Bulut Gulay , Tunc Huseyin , Hizel Candan Perry , Parlayan Cuneyd , Ekinci Ozalp , Van Schaik Ron , Akin Demet 
Published: January 2025

ABSTRACTPharmacogenetic studies involving Carboxylesterase 1 (CES1), Latrophilin‐3 (LPHN3), and Catechol‐O‐methyltransferase (COMT) revealed individual differences regarding therapeutic response in children with attention deficit hyperactivity disorder (ADHD) under methylphenidate (MPH) treatment. This study aimed to evaluate MPH's association with the adverse effect status in children and its relationship with CES1, LPHN3, and COMT in the Turkish population. The study included 102 children and adolescents with ADHD, who were categorized as responders, or the adverse effect group based on their treatment response. The Naranjo Adverse Drug Reaction Probability Scale evaluated the presence and severity of adverse effects. Saliva sample was taken from the patients and genotype distribution of CES1 rs3815583, CES1 rs2307227, LPHN3 rs6551665, LPHN3 rs1947274, LPHN3 rs6858066, LPHN3 rs2345039, and COMT rs4680 were examined. In the adverse effect group, instances of carrying the GG genotype in CES1 rs2307227, having G vs. T genotype and GG vs. GT were significantly higher. In LPHN3 rs2345039, carrying the C genotype vs. G was associated with a serious adverse effect. In COMT rs4680, individuals with the AA or GG genotype were significantly higher in the adverse effect group. Our study suggests a relationship between genetic polymorphisms and the side effect status in children receiving MPH.
Nutrition: A non‐negligible factor in the pathogenesis and treatment of Alzheimer's disease
Authors: Wen Boye , Han Xiaodong , Gong Jin , Wang Pin , Sun Wenxian , Xu Chang , Shan Aidi , Wang Xin , Luan Heya , Li Shaoqi , Li Ruina , Guo Jinxuan , Chen Runqi , Li Chuqiao , Sun Yao , Lv Sirong , Wei Cuibai 
Published: January 2025

AbstractAlzheimer's disease (AD) is a degenerative disease characterized by progressive cognitive dysfunction. The strong link between nutrition and the occurrence and progression of AD pathology has been well documented. Poor nutritional status accelerates AD progress by potentially aggravating amyloid beta (Aβ) and tau deposition, exacerbating oxidative stress response, modulating the microbiota–gut–brain axis, and disrupting blood–brain barrier function. The advanced stage of AD tends to lead to malnutrition due to cognitive impairments, sensory dysfunctions, brain atrophy, and behavioral and psychological symptoms of dementia (BPSD). This, in turn, produces a vicious cycle between malnutrition and AD. This review discusses how nutritional factors and AD deteriorate each other from the early stage of AD to the terminal stages of AD, focusing on the potential of different levels of nutritional factors, ranging from micronutrients to diet patterns. This review provides novel insights into reducing the risk of AD, delaying its progression, and improving prognosis.Highlights
Two‐fifths of Alzheimer's disease (AD) cases worldwide have been attributed to potentially modifiable risk factors.
Up to ≈26% of community‐dwelling patients with AD are malnourished, compared to 7%∼76% of institutionalized patients.
Undernutrition effects the onset, progression, and prognosis of AD through multiple mechanisms.
Various levels of nutritional supports were confirmed to be protective factors for AD via specific mechanisms.
Exploring the role of T cells in Alzheimer's and other neurodegenerative diseases: Emerging therapeutic insights from the T Cells in the Brain symposium
Authors: Elyaman Wassim , Stern Lawrence J. , Jiang Ning , Dressman Dallin , Bradley Philip , Klatzmann David , Bradshaw Elizabeth M. , Farber Donna L. , Kent Sally C. , Chizari Shahab , Funk Kristen , Devanand Davangere , Thakur Kiran T. , Raj Towfique , Dalahmah Osama Al , Sarkis Rani A. , Weiner Howard L. , Shneider Neil A. , Przedborski Serge 
Published: January 2025

AbstractThis proceedings article summarizes the inaugural “T Cells in the Brain” symposium held at Columbia University. Experts gathered to explore the role of T cells in neurodegenerative diseases. Key topics included characterization of antigen‐specific immune responses, T cell receptor (TCR) repertoire, microbial etiology in Alzheimer's disease (AD), and microglia–T cell crosstalk, with a focus on how T cells affect neuroinflammation and AD biomarkers like amyloid beta and tau. The symposium also examined immunotherapies for AD, including the Valacyclovir Treatment of Alzheimer's Disease (VALAD) trial, and two clinical trials leveraging regulatory T cell approaches for multiple sclerosis and amyotrophic lateral sclerosis therapy. Additionally, single‐cell RNA/TCR sequencing of T cells and other immune cells provided insights into immune dynamics in neurodegenerative diseases. This article highlights key findings from the symposium and outlines future research directions to further understand the role of T cells in neurodegeneration, offering innovative therapeutic approaches for AD and other neurodegenerative diseases.Highlights
Researchers gathered to discuss approaches to study T cells in brain disorders.
New technologies allow high‐throughput screening of antigen‐specific T cells.
Microbial infections can precede several serious and chronic neurological diseases.
Central and peripheral T cell responses shape neurological disease pathology.
Immunotherapy can induce regulatory T cell responses in neuroinflammatory disorders.
Antiviral effects and mechanism of Qi pi pill against influenza viruses
Authors: Zhang Chengcheng , Gao Jing , Dong Meiyue , Sacramento Carolina Q. , Li Ping , Lian Xiangyu , Fan Lingyuan , Rong Lijun , Du Ruikun , Tian Jingzhen , Cui Qinghua 
Published: January 2025

AbstractBackgroundQi pi pill (QPP), which contains Renshen, Baizhu, Fuling, Gancao, Chenpi, Shanyao, Lianzi, Shanzha, Liushenqu, Maiya, and Zexie, was recommended for preventing and treating COVID‐19 in Shandong Province (China). However, the mechanism by which QPP treats infectious diseases remains unclear. This study aims to investigate the therapeutic effect of QPP in vitro and on acute influenza infection in mice, exploring its mechanism of action against influenza A virus (IAV).MethodsThe in vitro activity of QPP was assessed using dose–response curve analysis and titer reduction assay, and its antiviral mechanism was identified in vitro by real‐time polymerase chain reaction (PCR), time‐of‐addition, and enzymatic assays. The antiviral efficacy of QPP was further evaluated in vivo using BALB/c mice infected with IAV. At the same time, each single Chinese herbal medicine in QPP was evaluated to preliminarily identify those with antiviral effects.ResultsIn vitro results showed that QPP exhibited a higher potency antiviral effect against both influenza A and B viruses, inhibiting viral RNA replication and release by targeting RNA‐dependent RNA polymerase and neuraminidase. Additionally, QPP significantly decreased the expression of inflammatory cytokines in A549 cells. In vivo study revealed that QPP significantly reduced the lung index and viral load in lung tissue of mice infected with IAV. Renshen, Gancao, Zexie, and Lianzi were the Chinese herbal medicines from QPP that showed anti‐IAV activity.ConclusionThe antiviral activity of QPP targets IAV replication and release, cytokine modulation in host cells, and provides protection in mice with acute influenza infection.
Straightforward Formation of Borirenes from Boroles and Dialkynes
Authors: Oliveira Pedro H. R. , Rodrigues Marieli O. , Da Silva Caren D. G. , Bohlen Josina L. , Arrowsmith Merle , Jayaraman Arumugam , Lubczyk Lukas , Fantuzzi Felipe , da Silva Júnior Eufrânio N. , Braunschweig Holger 
Published: January 2025

AbstractWe report a selective one‐step synthesis of perarylated borirenes by reaction of antiaromatic boroles with 1,4‐diarylbuta‐1,3‐diynes. Mechanistic studies, both experimental and computational, reveal key intermediates, including boranorbornadiene and 7‐borabicyclo[4.1.0]heptadiene species, which are all in equilibrium with each other, ultimately leading to borirene formation by migration of the boranediyl bridge from the cyclohexadiene ring to the remaining exocyclic alkyne residue.
Where Does the Proton Go? Structure and Dynamics of Hydrogen‐Bond Switching in Aminophosphine Chalcogenides
Authors: Huber Tanja , Mayer Gabriel , Kümper Manuel , Silva Wagner , Fontana Nicolò , Falk Alexander , Schreiner Simon H. F. , Gramüller Johannes , Scrimgeour Alexander , Groß Emily , Gschwind Ruth M. , Horinek Dominik , Nuernberger Patrick , Bauer Jonathan O. 
Published: January 2025

AbstractAminophosphates are the focus of research on prebiotic phosphorylation chemistry. Their bifunctional nature also makes them a powerful class of organocatalysts. However, the structural chemistry and dynamics of proton‐binding in phosphorylation and organocatalytic mechanisms are still not fully understood. Aminophosphine chalcogenides, preserving the central H2N−P+−Ch− structural motif, represent well‐suited molecular models that mimic proton‐binding, hydrogen‐bond switching and supramolecular self‐assembling behavior of catalytically and prebiotically relevant molecules. Through spectroscopic (IR, 1H DOSY, 15N NMR), molecular dynamics, and computational investigations, the dynamic proton switching capability of aminophosphate analogs was demonstrated. It was shown under which conditions the amino (NH2) or chalcogen (Ch) functions in H2N−P+−Ch− structural units are protonated. In fact, all conceivable modes of hydrogen‐bonding were identified, revealing substantial differences between the oxygen derivative and the heavier congeners. Using coordinating anions, supramolecular zigzag‐ and cube‐shaped arrangements were found in the solid‐state and in solution. After break‐up of the cube structure, the sulfides and selenides no longer form stable interactions with HCl molecules. In the absence of coordinating anions, however, protonation of the chalcogen function is preferred. In contrast to the oxygen derivative, the heavier protonated congeners show dynamic intramolecular proton‐hopping between the chalcogen and the amino function.
Evaluating the Mechanical and Tribological Properties of 3D Printed PLA/n‐HA/PA66 Composite
Authors: Guo Yonggang , Guo Zichao , Yin Zhendong 
Published: January 2025

ABSTRACTArtificial implants are necessary for orthopedic treatment and the recovery of bone and joint function in disabled individuals. However, existing materials present challenges in manufacturing complex structures and are limited in terms of mechanical and frictional properties. Current research is focused on the development of new environmentally friendly polymer composites for the manufacture of artificial implants, combined with 3D printing technology to improve design flexibility. In this study, nine kinds of PLA/n‐HA/PA66 composite scaffolds with different proportions were prepared using light‐curing 3D printing technology. The physical, mechanical, and tribological properties of the composite scaffolds were compared. The results showed that the PLA/n‐HA/PA66 composite scaffold was superior to traditional polymers, with compressive strength increased by 30–40 MPa and wear resistance increased by 27%–64%. This indicates that it has wide application potential in bone tissue engineering.
High Glass Transition PEcBT and PEPecBT Copolyesters Synthesized by Direct Esterification Route
Authors: Chen Yanru , Wu Linbo 
Published: January 2025

ABSTRACT2,2,4,4‐Tetramethyl‐1,3‐cyclobutanediol (CBDO) based copolyesters like poly(cyclohexane dimethylene‐co‐2,2,4,4‐tetramethyl cyclobutylene terephthalate) (PCcBT) has high transparency, heat‐resistance and safety and has been commercialized to replace bisphenol A polycarbonate in food contact applications. However, its synthesis and processing suffer from CBDO sublimation, composition deviation and relatively poor thermal stability. In order to obtain transparent heat‐resistant CBDO‐based copolyesters with improved synthesis robustness and thermal stability, poly(ethylene co‐tetramethyl cyclobutene terephthalate (PEcBT)) copolyesters were synthesized from ethylene glycol (EG), CBDO, and terephthalic acid (TPA) via direct esterification route, and the structure–property was studied. It is found that the presence of EG effectively inhibited the sublimation of CBDO, and the resulting PEcBT copolyesters had reasonably good thermal stability so that the melt polycondensation proceeded smoothly without serious foaming. PEcBT copolyesters with intrinsic viscosity ([η]) over 0.60 dL/g were successfully synthesized at copolymer composition (ϕcBT) up to 67 mol%. A quantitative relationship between Tg and its influence factors is established. The copolyesters with ϕcBT of 48–62 mol% displayed Tg of 126°C–144°C, flexible tensile behavior, satisfactory tensile properties and reasonably good impact performance. Ternary PEPecBT copolyesters were also synthesized using 1,5‐pentanediol as another diol comonomer to improve toughness of the materials.
Toward the Automation of the 3D Robotic Coreless Filament Winding Process for High‐Performance Composite Materials With Multiple Reinforcement Levels
Authors: Mersch Johannes , Friese Danny , Le Xuan Hung 
Published: January 2025

ABSTRACTRobotic coreless filament winding (CFW) of high‐performance materials in 3D geometries presents a promising avenue for advancing lightweight and civil engineering. However, the unique challenges posed by CFW necessitate the development of novel path planning algorithms. Traditional slicing techniques, commonly used in regular 3D printing, are inadequate due to the complexities of filament winding processes and the utilization of materials with exceptional mechanical properties. In this article, we propose an innovative approach to automate 3D robotic CFW. The key focus of our work lies in overcoming the limitations of conventional algorithms and addressing the specific boundary conditions associated with diverse applications. Our method builds upon Hierholzer's algorithm that is then expanded to accommodate the intricate constraints of CFW. We achieve a comprehensive path planning framework capable of navigating complex 3D geometries while optimizing the utilization of high‐performance materials. This approach allows efficient and precise CFW, preserving the excellent mechanical properties of the materials. Furthermore, the generated path is automatically converted into a robot program. The procedure to automatically convert a designed part to an executable robot program can be used in various sectors, including aerospace, automotive, and construction industry. This facilitates the utilization of high‐performance fiber composites in lightweight engineering applications in the future.
Recovering or Still Depleted? Updated Population Assessment of Tappanaga, a Northern Local Population of Short‐Finned Pilot Whales (Globicephala macrorhynchus) off the Coast of Japan
Authors: Kanaji Yu , Maeda Hikari , Sasaki Hiroko 
Published: January 2025

ABSTRACTThe northern form (often called Tappanaga type) population of short‐finned pilot whales (T‐SPW) is a local population that inhabits the Kuroshio‐Oyashio mixed water regions off northern Japan. The population has been severely depleted by past whaling. Rigorous management was first introduced in the 1980s, and whalers have voluntarily refrained from taking T‐SPW since 2007. Our primary goal is to investigate whether the T‐SPW population has recovered. We estimated recent abundances based on data from the line‐transect sighting surveys dedicated to T‐SPW. Simple population dynamics models were fitted to these and previously published estimates for 1985–2006. When a detection probability on the track line was assumed to be 1 (g(0) = 1), the estimated abundances in 2007, 2021 and 2022 were 1659 (coefficient of variation, CV = 0.79), 2634 (0.93) and 759 (0.64), respectively. The population dynamics model showed that past whaling substantially reduced abundance, and no clear tendency for population recovery was seen even after the voluntary suspension of whaling. Compared with the estimated carrying capacity, the current population size was still considered to be nearly depleted. To improve the conservation and management measures, we need more efforts to identify the causes of nonrecovery of the T‐SPW population.