bluuebunny/crossref_metadata_2025_split huggingface dataset:
Evaluating the effect of a mixture of Lactobacillus brevis and Lactobacillus plantarum on the management of periodontitis stage III grade C molar-incisor pattern in Egyptian patients
( Randomize control trial)
Authors: Ibrahim Ibrahim Hammad , Edrees Mohamed Fouad , EL-Mokhtar Mohamed Ahmed , Hammad Heba Ali , kotb Shimaa Hussein 
Published: January 2024

Abstract
Periodontitis is a common disease that represents a public health problem. Aggregatibacter actinomycetemcomitans (A. a ) especially the JP2 genotype plays a major role in the pathogenesis of periodontitis. The aim of this study is to evaluate the effect of topically applied probiotics on the management of periodontitis stage III grade C molar-incisor pattern. Methods: Sixty-five patients having periodontitis stage III grade C molar-incisor pattern. Screening for A. actinomycetemcomians (A.a) and the JP2 genotype was done using conventional polymerase chain reaction (PCR). Patients positive for (A. a) were randomly divided into two groups. Group I: received conventional periodontal treatment combined with topically applied probiotic, while Group II: received conventional periodontal treatment only. Both groups were evaluated microbiologically and clinically. Quantitative assessment of A. a levels was done by real time PCR (qPCR) at baseline as well as one week, 4 weeks, and 12 weeks after treatment. Clinical parameters were assessed before treatment as well as 3,6 and 9 months after treatment. Results: Both treatment groups showed reduction in the levels of A.a as well as clinical parameters at different intervals. Although the use of probiotics plus SRP had a better effect in reducing the levels of A.a and clinical parameters at different intervals than SRP only, the difference between both groups was statistically non-significant. Conclusion: The low prevalence of A. a among patients with periodontitis stage III grade C molar-incisor pattern makes the role of A. a questionable as an important risk factor. Thus, additional studies are needed with large sample size. Probiotics as an adjuvant therapy might have a promising effect, as an alternative to antibiotics, in the management of periodontitis in the future.
High disease activity influences the presence of vertebral fractures in rheumatoid arthritis
Authors: Sakane Hideo , Okamura Koichi , Iizuka Yoichi , Honda Akira , Takasawa Eiji , Mieda Tokue , Yonemoto Yukio , Suto Takahito , Kaneko Tetsuya , Chikuda Hirotaka 
Published: January 2024

Abstract
Introduction: It is important to assess the risk of vertebral fractures (VFs) in patients with rheumatoid arthritis (RA), as RA is associated with a high risk of VFs. However, the epidemiology and risk of VFs in patients with RA remain inconclusive. The present study therefore clarified the prevalence and associated factors of VFs in patients with RA.
Methods: We included 107 patients (19 men and 88 women) and retrospectively investigated the number and location of VFs, bone mineral density (BMD), RA disease activity score for 28 joints based on C-reactive protein (DAS28-CRP), and history of medication for RA and osteoporosis. Based on the investigated items, we assessed the prevalence of VFs in patients with RA and the association between the clinical parameters of RA patients and VFs.
Results: The average age, disease duration, and DAS28-CRP were 67.9 years old, 14.9 years, and 2.2, respectively. We found that the prevalence of VFs in patients with RA was 30.8%, and 84.8% of patients with VFs and 62.2% of those without VFs had been treated for osteoporosis. We further found that the prevalence of VFs in patients with RA with a history of anti-osteoporotic agent use was 37.8%. In univariate analyses, patients with RA with VFs had significantly higher DAS28-CRP values, a higher rate of corticosteroid use, and lower BMD (p = 0.018, p = 0.004, and p < 0.001, respectively) than those without VFs. A logistic regression analysis and ordinal logistic analysis revealed that the DAS28-CRP and BMD were independent factors associated with the presence (p = 0.042 and p = 0.011, respectively) and number (p = 0.036 and p = 0.048, respectively) of VFs.
Conclusions: The prevalence of VFs was relatively high in patients with RA, regardless of the use of anti-osteoporotic agents. A high disease activity score and low BMD are associated with the presence and number of VFs in patients with RA. Based on these findings, to reduce VFs in RA patients, it is important to tightly control the disease activity of RA and aggressively treat osteoporosis.
SUSTAINABLE COMPANY PROFILE DEVELOPMENT FOR MSMEs IN JAKARTA
Authors: Sarjono Haryadi , Ariska Popi 
Published: January 2024

The purpose of this research is to assist SMEs in creating a sustainable company profile as an information medium that is needed today and is expected to be used as a solution, means of information, and promotion needed by companies, considering that a company profile is an asset that can be used to enhance an image or image. from the company to establish cooperation with relations, institutions and other relevant agencies. As a result of the pandemic, many MSMEs have sprung up around us and when a marketing opportunity for these MSME products came and were asked to immediately send their company profiles, many could not send them, because they did not have a company profile. It's really unfortunate considering that several opportunities have to be let go, because this is a very good opportunity to increase the credibility of these MSMEs. The research method used is a mixture of quantitative and qualitative with descriptive analysis techniques. This research was conducted from July to November 2022, for 5 months. The research population is only 1 MSME located around the West Jakarta area. Data collection tools and techniques are study guideline questionnaires, interviews, and focus group discussions (FGD). The results of the research have made a company profile where the contents and information in it have been mutually agreed upon using Canva tools, so that it can be changed later if there is new information that needs to be filled in.

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Unraveling the potential of microbial communities for lake bioremediation via the metagenomics tool: a review
Authors: Nandy Sampurna , Kapley Atya 
Published: January 2024

Abstract

Characterization of ubiquitous microorganisms has encountered many challenges, such as determining unknown microorganisms, their interactions, and unresolved functions in natural environments. Evolution in metagenomics and tools, however, has revolutionized assessment methodologies. Metagenomics has enabled unearthing the secret microbial treasure in a culture-independent manner and has proven more successful than conventional methodologies. It has provided an unparalleled platform for functional and taxonomic characterization of microbiota dwellings in altered lakes. Of late, many research articles have used metagenomics to understand microorganisms’ role in environmental clean-up. Consequently, these studies have been consolidated in the form of review articles. However, most of them are related to microbial characterization, procedure of metagenomics, and wastewater treatment, whereas only a few were directly related to lake bioremediation. Therefore, this review highlights the applications of metagenomics for unraveling microbial potential for lake rejuvenation. A paradigm shift from conventional to recent breakthroughs in metagenomics is also emphasized. The review also discusses merits, demerits of previous molecular techniques, and potential of metagenomics for understanding the microbial world in contaminated environments. Furthermore, the review discusses recent metagenomic studies for lake rejuvenation. Finally, future research directions are proposed for designing possible strategies for lake rejuvenation.
Challenges in developing trust in the rural drinking water supply systems
Authors: Bombade Ambrish 
Published: January 2024

Abstract

The water sector in developing countries continues to tackle the emergent challenges of increasing demand for water by the growing population, poor cost recovery from the users, ageing infrastructure and intermittent water supply regime. The national and sub-national governments entrusted the community to tackle these challenges. This led to the emergence of community-managed rural water supply systems where ‘Building Trust with Stakeholders’ is an essential concern for the sustainable functioning of the rural drinking water supply schemes. Trust is developed by engaging stakeholders in decision-making and the overall knowledge-sharing process. However, maintaining and sustaining trust is challenging in the context of the above-mentioned challenges. Amongst all the concerned stakeholders of the water sector, building the service provider's trust with the residential water users is an important aspect. Building upon the given context, this study attempts to understand the trustful relationship among the three key stakeholders of the rural drinking water sector: Scheme operating agencies, village local self-government bodies and their residential water users. The study aims to utilise the learnings from the trust research to empirically understand the factors shaping the trustful relationship between the stakeholders in India's rural drinking water sector.
Pharmacological Effects of FTY720 and its Derivatives
Authors: Han Mengyuan , Liu Xiangran , Hailati Sendaer , Maihemuti Nulibiya , Nurahmat Nurbiya , Dilimulati Dilihuma , Baishan Alhar , Aikebaier Alifeiye , Zhou Wenting , Pan Yan 
Published: January 2024

Abstract:
FTY720 is an analog of sphingosine-1-phosphate (S1P) derived from the ascomycete
Cordyceps sinensis. As a new immunosuppressant, FTY720 is widely used to treat multiple sclerosis.
FTY720 binds to the S1P receptor after phosphorylation, thereby exerting immunosuppressive
effects. The nonphosphorylated form of FTY720 can induce cell apoptosis, enhance chemotherapy
sensitivity, and inhibit tumor metastasis of multiple tumors by inhibiting SPHK1 (sphingosine
kinase 1) and activating PP2A (protein phosphatase 2A) and various cell death pathways. FTY720
can induce neutrophil extracellular traps to neutralize and kill pathogens in vitro, thus exerting anti-
infective effects. At present, a series of FTY720 derivatives, which have pharmacological effects
such as anti-tumor and alleviating airway hyperresponsiveness, have been developed through
structural modification. This article reviews the pharmacological effects of FTY720 and its derivatives.
Association Between Nutrients and Cardiovascular Diseases
Authors: Shakarami Amir 
Published: January 2024

Abstract:
Cardiovascular diseases (CVD) constitute a leading cause of global mortality. Inflammation and oxidative stress are key molecular underpinnings of CVD pathogenesis. This
comprehensive review explores the multifaceted role of nutrients in cardiovascular health beyond their impact on cardiac events. The manuscript examines the influence of macronutrients
such as fats and carbohydrates, as well as micronutrients including vitamins and folate, on CVD.
Additionally, the interplay between dietary supplements and CVD risk reduction is investigated.
The purpose of this manuscript is to provide a comprehensive overview of the diverse mechanisms through which nutrients contribute to cardiovascular well-being, addressing both cardioprotective effects and their broader implications. Through an analysis of pertinent studies, we
illuminate the complex relationship between nutrition, lifestyle, and cardiovascular health, underscoring the significance of a holistic approach to CVD prevention and management.
Euclea natalensis Suppresses Postprandial Hyperglycemia in Rats via the
Inhibition of α-Glucosidase: In vitro, in vivo, and Molecular Docking Studies
Authors: Bati Keagile , Majinda Runner R.T , Gaobotse Goabaone , Kwape Tebogo E. 
Published: January 2024

Background::
Postprandial hyperglycemia is a key factor in type 2 diabetes, and its
management is critical in alleviating the deleterious consequences of diabetes and its associated
micro and macrovascular complications.

Objective::
The current study aims to determine the effect of Euclea natalensis leaf extracts on α-
glucosidase inhibition in vitro and postprandial hyperglycemia in vivo in rats.

Methods::
Sequentially extracted leaf extracts of Euclea natalensis were evaluated for their inhibitory
effects on α-glucosidase in vitro and the suppression of postprandial hyperglycemia in
normoglycemic rats. The extracts were fingerprinted using a Fourier-transform infrared spectrophotometer
(FTIR), and the bioactive compounds were evaluated by molecular docking for their
interaction with α-glucosidase.

Results::
FTIR fingerprinting of the extracts showed that they contain functional groups of important
bioactive phytochemicals. The extracts inhibited α-glucosidase in vitro, with the methanol
extract (1 mg/mL) showing the highest inhibitory effect of 93.52 ± 1.50% compared to
69.62% ± 1.45 of the standard drug acarbose (0.05 mg/mL). The extracts also reduced postprandial
hyperglycemia in rats in a sucrose tolerance test, where the hexane and methanol extracts
performed similarly to Acarbose. Molecular docking studies showed that 20(29)-lupene-3β-
isoferulate 3 is the most potent α-glucosidase inhibitor with the lowest binding energy of -10.79
kcal/mol, 2 hydrogen bonds with residues ASP1526 and ASP1157, and numerous Van der Waal
interactions with amino acids in the binding pocket of α-glucosidase.

Conclusion::
Euclea natalensis leaf extracts were found to suppress postprandial hyperglycemia
by inhibiting α-glucosidase activity; thus, it has a promising potential for use as an antidiabetic
agent.
Research on a New Synchronous Phase-Locked Method for Renewable
Energy Grid-connected Converters
Authors: Hui Nanmu , Han Xiaowei , Wu Baoju 
Published: January 2024

Background::
The phase-locked loop (PLL) is widely used to estimate synchronization
information such as magnitude and phase angle of the grid voltage, which is essential for gridconnected
power generation from distributed renewable energy sources. However, the harmonics
in the grid often affect the accurate extraction of fundamental positive sequence, resulting in
phase deviations.

Methods::
A dual extended novel third-order generalized integrator (DENTOGI) is proposed and
placed into the control outer loop of the PLL. This approach can be applied in the condition of
the grid with DC offset voltage (DCOV). Additionally, the PLL is proposed by introducing moving
average filter (MAF) and eliminating the proportional controller of the integration link to
suppress high-frequency harmonics and speed up the response.

Results::
A comparative experiment using Matlab/Simulink is conducted to evaluate the proposed
PLL against the conventional PLLs. The experimental results confirm that the proposed PLL exhibits
superior filtering performance for DC offset and harmonic components when compared to
the conventional PLL. Additionally, the proposed PLL demonstrates better dynamic adjustment
capabilities.

Conclusion::
The main contribution of this paper is to propose a phase-locked method that can
eliminate DCOV and harmonic components, which can be applied in non-ideal power grid conditions.
The proposed PLL based on DENTOGI and MAF can lock the grid phase stably without
errors under the grid fault involving DCOV and harmonic disturbance, it also exhibits the characteristics
of fast response.
A Secured Privacy-preserving Multifactor Approach for Autonomous Vehicles Using Blockchain Technology
Authors: Sarika Sabavath , Prabakeran S. 
Published: January 2024

Background and Aims:
Smart vehicles are connected to the Internet of Things (IoT),
bringing with them the potential to transform human existence in so-called "smart cities." Intelligent vehicle architecture revolves around the Vehicular-AdhocNetwork(VANET). The goal of a
VANET is to make driving more pleasant. VANETs' message-sharing capabilities contribute to
improved traffic management, reduced congestion, and safer driving. However, VANETs' usefulness could be diminished by the spread of fraudulent or erroneous messages

Objectives and Methodology:
For better road safety and less congestion, it guarantees secure and
accurate communication between vehicles and between vehicles and infrastructure. The security
and privacy of a VANET, however, can be compromised by threats, including denial-of-service
(DoS), replay, and Sybil attacks. These problems can cause a rogue node to send out faulty data
throughout the system. We introduce a biometrics-blockchain(BBC) approach to ensure the safety
of information exchanged between vehicles in a VANET and to preserve archival data in a triedand-true environment. To protect the anonymity of users, the suggested framework makes use of
biometric data to verify the identity of the sender.

Results and Conclusion:
As a result, the proposed BBC scheme creates a safe and reliable environment for vehicles in VANET, with the added benefit of identity tracing capabilities. To prove
the effectiveness of the proposed framework, simulations were run in the urban mobility models
OMNeT++, veins, and SUMO. Packet-delivery-rate(PDR), packet-loss-rate(PLR), and computing
cost (CC) were used to assess the framework's efficiency. The outcomes highlighted the superiority of our innovative model over conventional methods, such as PDR slightly increased to 8-10%,
PLR decreased to 20-25%, and CC also reduced to 15-20% compared to state-of-art models.
New modified Bat algorithm for blind speech enhancement in time domain
Authors: Fisli Sofiane , Djendi Mohamed 
Published: January 2024

We address the speech enhancement problem for dual convolutif mixed channel by viewing it in a blind separation sources setting. One widely used technique to separate mixed signals is to apply adaptive filtering, the challenge is to identify an unknown finite impulse response. traditionally we apply a gradient-based algorithm to adapt filter coefficients. However, such algorithm often suffers from premature convergence ,when using large filters and non-stationary inputs , leading to the so-called local minimum problem , which affects the quality of enhanced signals significatively .one alternative to overcome this problem is to apply a population-based metaheuristic algorithms in which filter coefficients are adapted iteratively by minimizing a cost function .But even with this metaheuristic based solution, local minimum problem at large filters still exists. In order to avoid local minima and improve the chance to reach the global solution, we propose in this paper, a novel algorithm called a modified bat algorithm to render the search process efficiently by enhancing its capability of exploration and exploitation. Several experiments under different noise types are carried out using our proposed modified bat algorithm in comparison with some of the popular state-of-the-art algorithms. The enhanced signals obtained by each algorithm at the separation process outputs, show good behavior and superiority of our proposed algorithm. In terms of system misalignment, as well as a segmental signal-to-noise ratio.
ANÁLISE ESPACIAL DOS CASOS DE COVID-19 EM SÃO GONÇALO NO PERÍODO DE 2020 A 2022
Authors: Afonso Boechat Davi , Oliveira Bastos Jonathan , Pacheco do Nascimento da Silva Marcos Vinícius , De Abreu Amorim Anna Clara , Valente Cardoso Phillipe 
Published: January 2024

A pandemia da Síndrome Respiratória Aguda Grave do Coronavírus 2 (Sars-Cov-2) declarada pela Organização Mundial de Saúde (OMS) em janeiro de 2020 vem se estendendo ao longo de 2022 caminhando para seu terceiro ano. Porém atualmente a pandemia encontra-se emum cenário diferente dos períodos iniciais, tanto em seus protocolos de prevenção e vacinação quanto nas novas cepas e seus sintomas. Dentro desse contexto, a geografia junto ao geoprocessamento reafirma sua importância na capacidade de realização de análises espaciais e tomadas de decisões frente a essa conjuntura sanitária. Dessa forma, o presente trabalho tem como objetivo espacializar e analisar os casos de COVID-19 no município de São Gonçalo-RJ ao longo de todo período pandêmico, onde ocorreram um aumento significativo de casos em quatro períodos: fevereiro até maio de 2020, setembro até dezembro de 2020, fevereiro a maio de 2021 e novembro de 2021 até janeiro de 2022. Para isso, foram realizados os georreferenciamento pela plataforma do ArcGis 10.8.2 de casos acumulados nos meses por bairro e em seguida esses casos foram associados como pesos aos respectivos centroides de cada bairro de São Gonçalo. Posteriormente, foi utilizada a fórmula de Hermuche, 2013 para obter os vetores de deslocamento. Dentre os resultados percebeu-se que as quatro ondas embora apresentem comportamentos distintos, o vetor de direção sempre acaba tendendo a ir a nordeste do município devido a influência do bairro Jardim Catarina.
Decomposição dos diferenciais de salários no Brasil nos anos de 2012 e 2018: a discriminação entre homens, mulheres sem filhos e mulheres com filhos no mercado de trabalho
Authors: Machado Marra da Silva Beatriz , Rodrigues da Silva Ana Márcia , De Souza Veloso Manoel Vítor 
Published: January 2024

Por meio deste artigo objetiva-se analisar as diferenças nos rendimentos do trabalho entre homens, mulheres sem filhos e mulheres com filhos no mercado de trabalho brasileiro e evidenciar se estas diferenças estão relacionadas à discriminação. Para tanto foi realizada a decomposição de Oaxaca-Blinder a partir dos dados da PNADC dos anos de 2012 e 2018. Os resultados indicaram maior diferença nos rendimentos do trabalho entre homens e mulheres com filhos, influenciada, em geral, pela discriminação; e menores diferenças entre mulheres com filhos e sem filhos.
Aktivitas Hemostatik Lokal Beberapa Varietas Getah Batang Pohon Pisang (Musa parasidiaca)
Authors: Vitamia Cszahreyloren 
Published: January 2024

AbstrakMasyarakat Indonesia telah menjunjung tinggi tradisi penggunaan herbal secara turun-temurun, dan salah satu contoh yang menonjol adalah pemanfaatan pohon pisang (Musa paradisiaca) untuk khasiat pengobatannya. Oleh karena itu, telah dilakukan penelitian untuk menilai aktivitas hemostatik lokal berbagai jenis getah batang semu pisang dengan mengukur waktu pendarahan pada hewan percobaan. Penelitian ini menggunakan metode Duke, dengan memberikan luka ringan pada ekor tikus. Tikus Swiss Webster jantan dibagi menjadi lima kelompok. Hasilnya, rata-rata ± SD waktu pendarahan pada kelima kelompok adalah sebagai berikut: kelompok kontrol negatif, kontrol positif, dan perlakuan dengan getah batang semu pisang ambon, nangka-pisang, dan pisang siem berturut-turut 305,40 ± 79,45; 88,00±29,45; 81,20 ± 91,19; 199,20 ± 64,77; dan 135,40 ± 31,19 detik. Data yang terkumpul dilakukan analisis statistik ANOVA yang dilanjutkan dengan uji LSD. Secara signifikan, terdapat perbedaan antara kelompok kontrol negatif dan kelompok perlakuan lainnya di antara kelima kelompok. Namun tidak terdapat perbedaan nyata antara ketiga kelompok perlakuan yang melibatkan berbagai varietas getah batang pohon pisang. Penelitian mengungkapkan bahwa getah batang pisang semu dapat secara efektif mengurangi waktu pendarahan pada tikus.