bluuebunny/crossref_metadata_2025_split huggingface dataset:
A bioenergetically‐active ploy (glycerol sebacate)‐based multiblock hydrogel improved diabetic wound healing through revitalizing mitochondrial metabolism
Authors: Qi Xin , Liu Chenjun , Si Jingyi , Yin Bohao , Huang Jingjing , Wang Xin , Huang Jinghuan , Sun Hui , Zhu Changfeng , Zhang Wei 
Published: February 2024

AbstractDiabetic wounds impose significant burdens on patients' quality of life and healthcare resources due to impaired healing potential. Factors like hyperglycemia, oxidative stress, impaired angiogenesis and excessive inflammation contribute to the delayed healing trajectory. Mounting evidence indicates a close association between impaired mitochondrial function and diabetic complications, including chronic wounds. Mitochondria are critical for providing energy essential to wound healing processes. However, mitochondrial dysfunction exacerbates other pathological factors, creating detrimental cycles that hinder healing. This study conducted correlation analysis using clinical specimens, revealing a positive correlation between mitochondrial dysfunction and oxidative stress, inflammatory response and impaired angiogenesis in diabetic wounds. Restoring mitochondrial function becomes imperative for developing targeted therapies. Herein, we synthesized a biodegradable poly (glycerol sebacate)‐based multiblock hydrogel, named poly (glycerol sebacate)‐co‐poly (ethylene glycol)‐co‐poly (propylene glycol) (PEPGS), which can be degraded in vivo to release glycerol, a crucial component in cellular metabolism, including mitochondrial respiration. We demonstrate the potential of PEPGS‐based hydrogels to improve outcomes in diabetic wound healing by revitalizing mitochondrial metabolism. Furthermore, we investigate the underlying mechanism through proteomics analysis, unravelling the regulation of ATP and nicotinamide adenine dinucleotide metabolic processes, biosynthetic process and generation during mitochondrial metabolism. These findings highlight the therapeutic potential of PEPGS‐based hydrogels as advanced wound dressings for diabetic wound healing.
Development and initial validation of the AL‐PROfile patient‐reported outcome measure in light chain (AL) amyloidosis
Authors: D'Souza Anita , Szabo Aniko , Akinola Idayat , Finkel Muriel , Flynn Kathryn E. 
Published: February 2024

AbstractObjectiveTo evaluate the psychometric properties of the AL‐PROfile, a patient‐reported outcome measure combining the Patient‐Reported Outcomes Measurement Information System (PROMIS)‐29, two items from PROMIS Cognitive Function, and select Patient‐Reported Outcomes version of the Common Terminology Criteria for Adverse Events (PRO‐CTCAE) items.MethodsContent validity was assessed through cognitive debriefing interviews of 20 patients who completed the AL‐PROfile (Study 1). Study 2 involved 297 participants who completed the AL‐PROfile and Medical Outcomes Study 36‐item Short‐Form Health Survey (SF‐36). Reliability (internal consistency and test–retest reliability) and validity (convergent and discriminant validity, known groups validity by stage/organ involvement) were calculated.ResultsStudy 1 participants found the AL‐PROfile straightforward confirming the relevance of the included content. Some felt that certain questions were not related to their amyloidosis experience. Study 2 demonstrated acceptable internal consistency for all domains/items except PROMIS Cognitive Function and acceptable test–retest reliability for all except PROMIS Cognitive Function and PRO‐CTCAE nausea. Large correlations were seen for the same domain across measures while correlations for divergent domains within a measure and different domains across different measures were small. The PRO‐CTCAE items showed small to medium correlations with each other and with PROMIS and SF‐36 domains. Stage was associated with physical function, fatigue, social roles, swelling, and shortness of breath scores.ConclusionThe AL‐PROfile has acceptable reliability and validity for use in systemic light chain amyloidosis patients.
Pancreas‐related persisting sequelae in ALL survivors with a history of asparaginase‐associated pancreatitis: A part of the ALL‐STAR study
Authors: Skipper Mette Tiedemann , Birkebæk Niels , Jensen Rikke Beck , Rank Cecilie Utke , Tuckuviene Ruta , Wehner Peder Skov , Lambine Trine‐Lise , Hørlyck Arne , Schmiegelow Kjeld , Frandsen Thomas Leth , Andrés‐Jensen Liv , Albertsen Birgitte Klug 
Published: February 2024

AbstractObjectivesAsparaginase‐associated pancreatitis (AAP) occurs in up to 18% of patients treated for acute lymphoblastic leukemia (ALL); however, long‐term sequelae are largely unexplored. We aimed to explore pancreatic sequelae among ALL survivors with and without AAP.MethodsWe investigated pancreatic sequelae in a national cohort of ALL survivors, aged 1–45 years at ALL diagnosis treated according to the NOPHO‐ALL2008 protocol and included sex‐ and age‐matched community controls.ResultsWe included 368 survivors (median follow‐up 6.9 years), including 47 survivors with AAP and 369 controls. The p‐lipase and p‐pancreas‐type amylase levels were lower in AAP survivors compared with both non‐AAP survivors (Medians: 23 U/L [IQR 14–32] and 18 U/L [IQR 10–25] versus 29 [IQR 24–35] and 22 [17–28], p < .001 and p = .002) and community controls (28 U/L [IQR 22–33] and 21 U/L [IQR 17–26], both p < .006). Fecal‐elastase was more frequently reduced in AAP survivors compared with non‐AAP survivors (7/31 vs. 4/144, p = .001). Persisting pancreatic sequelae were found in 15/47 of AAP survivors and 20/323 of non‐AAP survivors (p < .001), including diabetes mellitus in 2/39 of AAP survivors and 2/273 of non‐AAP survivors.ConclusionsALL survivors with AAP are at increased risk of persisting pancreatic dysfunction and require special attention during follow‐up.
Genomic evidence for domestication selection in three hatchery populations of Chinook salmon, Oncorhynchus tshawytscha
Authors: Howe Natasha S. , Hale Matthew C. , Waters Charles D. , Schaal Sara M. , Shedd Kyle R. , Larson Wesley A. 
Published: February 2024

AbstractFish hatcheries are widely used to enhance fisheries and supplement declining wild populations. However, substantial evidence suggests that hatchery fish are subject to differential selection pressures compared to their wild counterparts. Domestication selection, or adaptation to the hatchery environment, poses a risk to wild populations if traits specific to success in the hatchery environment have a genetic component and there is subsequent introgression between hatchery and wild fish. Few studies have investigated domestication selection in hatcheries on a genomic level, and even fewer have done so in parallel across multiple hatchery–wild population pairs. In this study, we used low‐coverage whole‐genome sequencing to investigate signals of domestication selection in three separate hatchery populations of Chinook salmon, Oncorhynchus tshawytscha, after approximately seven generations of divergence from their corresponding wild progenitor populations. We sequenced 192 individuals from populations across Southeast Alaska and estimated genotype likelihoods at over six million loci. We discovered a total of 14 outlier peaks displaying high genetic differentiation (FST) between hatchery–wild pairs, although no peaks were shared across the three comparisons. Peaks were small (53 kb on average) and often displayed elevated absolute genetic divergence (Dxy) and linkage disequilibrium, suggesting some level of domestication selection has occurred. Our study provides evidence that domestication selection can lead to genetic differences between hatchery and wild populations in only a few generations. Additionally, our data suggest that population‐specific adaptation to hatchery environments likely occurs through different genetic pathways, even for populations with similar standing genetic variation. These results highlight the need to collect paired genotype–phenotype data to understand how domestication may be affecting fitness and to identify potential management practices that may mitigate genetic risks despite multiple pathways of domestication.
Research on a creep constitutive model of compacted graphite cast iron and its parameter identification method
Authors: Jing Guoxi , Ma Tian , Ma Teng , Li Shubo , Chen Guang , Sun Xiuxiu , Sun Shuai 
Published: February 2024

AbstractIn order to accurately predict the minimum creep rate under the actual working conditions of compacted graphite cast iron cylinder head, this paper conducted creep experiments in the temperature range of 723.15–823.15 K and the stress range of 100–300 MPa. The creep damage evolution and damage mechanisms under test conditions were also analyzed. Then the data fitting performances were analyzed and compared from three aspects: the optimization‐seeking algorithm, the form of the objective function and the construction of the creep constitutive model. Finally, the chosen optimization algorithm combined with the proposed objective function and creep constitutive model resulted in 100% of the predicted values within the 3 times error band and 26.67% of the predicted values within the 1.5 times error band. This improves the prediction accuracy while reducing the effect of data overfitting.
Matteo Ricci's teaching on the goodness of human nature: its Thomistic and neo‐Confucian sources
Authors: Cai Yilun 
Published: February 2024

AbstractThe Jesuit missionary Matteo Ricci's teaching on the goodness of human nature in The True Meaning of the Lord of Heaven represents the fruit of the first encounter between Catholicism and Confucianism. This article will consider the Thomistic and neo‐Confucian sources in Ricci's enunciation of the Catholic doctrine on the goodness of human nature in this Chinese catechism. It will illustrate that Ricci developed his teaching, which is fundamentally Thomistic, with the help of terminology borrowed from the Chinese philosophical tradition. His distinction between the good of nature and the good of virtue leads to prioritising the cultivation of human nature. Ricci's teaching reflects the early modern Jesuits’ appreciation of human freedom. It also displays a Catholic reaction to the sixteenth‐century neo‐Confucian intellectual trend that ignored the importance of moral cultivation.
Cytomegalovirus infection among people living with HIV in Sweden: Case profiles, treatment strategies and patient outcomes at Karolinska University Hospital 2010–2020
Authors: Xu Xinling , Andersson Emmi , Rahbar Afsar , Söderberg‐Nauclér Cecilia , Nowak Piotr 
Published: February 2024

AbstractObjectivesIn countries with access to early antiretroviral treatment (ART), opportunistic infections caused by cytomegalovirus (CMV) in people living with HIV (PLWH) are becoming increasingly rare. As potential complications are severe, it is critical to remain aware of this important diagnosis. However, clinical characteristics and prognosis of CMV infection in PLWH in the era of modern ART have not been well described.MethodsHere, we compiled the clinical presentation, management and outcome of CMV infection in PLWH treated at the infectious diseases clinic of Karolinska University Hospital during 2010–2020.ResultsWe identified 51 cases of active CMV infection, based on detection of CMV‐DNA, mainly diagnosed in patients with CD4 T‐cell count <200 cells/μL (86%). Median time from HIV diagnosis to detection of CMV infection was 16 days. In 20 cases (39%), CMV infection was symptomatic with retinitis identified as a manifestation in 70% of cases. Symptomatic CMV infection was treated for 73 (20–313) days upon diagnosis, mostly using valganciclovir. One‐year mortality was 22% and was associated with longer time to ART initiation from HIV diagnosis and with comorbidities, but not with CMV‐DNA levels or CD4 count. Immune reconstitution was not significantly compromised in patients with symptomatic CMV, although CD4/8 ratio tended to be lower in patients with systemic CMV infection.ConclusionsRetinitis remains the most common manifestation of symptomatic CMV infection in PLWH. Recognizing CMV infection is important, especially in the management of ‘late presenters’. Adequate duration of antiviral therapy and appropriate follow‐up must be ensured to avoid complications.
Clinicopathological and cellular senescence biomarkers in chronic stalled wounds
Authors: Yu Grace T. , Gomez Paul T. , Prata Larissa G. , Lehman Julia S. , Tchkonia Tamar , Kirkland James L. , Meves Alexander , Wyles Saranya P. 
Published: February 2024

AbstractBackgroundChronic wounds have been associated with an elevated burden of cellular senescence, a state of essentially irreversible cell cycle arrest, resistance to apoptosis, and a secretory phenotype. However, whether senescent cells contribute to wound chronicity in humans remains unclear. The objective of this article is to assess the role of clinicopathological characteristics and cellular senescence in the time‐to‐healing of chronic wounds.MethodsA cohort of 79 patients with chronic wounds was evaluated in a single‐center academic practice from February 1, 2005, to February 28, 2015, and followed for up to 36 months. Clinical characteristics and wound biopsies were obtained at baseline, and time‐to‐healing was assessed. Wound biopsies were analyzed histologically for pathological characteristics and molecularly for markers of cellular senescence. In addition, biopsy slides were stained for p16INK4a expression.ResultsNo clinical or pathological characteristics were found to have significant associations with time‐to‐healing. A Cox proportional hazard ratio model revealed increased CDKN1A (p21CIP1/WAF1) expression to predict longer time‐to‐healing, and a model adjusted for gender and epidermal hyperplasia revealed increased CDKN1A expression and decreased PAPPA expression to predict longer time‐to‐healing. Increased p16INK4a staining was observed in diabetic wounds compared to non‐diabetic wounds, and the same association was observed in the context of high dermal fibrosis.ConclusionsThe findings of this pilot study suggest that senescent cells contribute to wound chronicity in humans, especially in diabetic wounds.
Wars of attrition with spending constraints
Authors: Hwang Sung‐Ha , Koh Youngwoo 
Published: February 2024

AbstractWe study wars of attrition with spending constraints. Specifically, there are two players with different values of the prize and costs of continuing wars, and they are endowed with limited budgets that can be used during the war. Two players compete by choosing the time at which they intend to give up within the constraints. We find the constrained mixed strategy equilibrium for this model and provide a full characterization of equilibrium depending on whether each player's constraint is binding or nonbinding.
Statistical proxy based mean‐reverting portfolios with sparsity and volatility constraints
Authors: Mousavi Ahmad , Michilidis George 
Published: February 2024

AbstractMean‐reverting portfolios with volatility and sparsity constraints are of prime interest to practitioners in finance since they are both profitable and well‐diversified, while also managing risk and minimizing transaction costs. Three main measures that serve as statistical proxies to capture the mean‐reversion property are predictability, portmanteau criterion, and crossing statistics. If in addition, reasonable volatility and sparsity for the portfolio are desired, a convex quadratic or quartic objective function, subject to nonconvex quadratic and cardinality constraints needs to be minimized. In this paper, we introduce and investigate a comprehensive modeling framework that incorporates all the previous proxies proposed in the literature and develop an effective unifying algorithm that is enabled to obtain a Karush–Kuhn–Tucker (KKT) point under mild regularity conditions. Specifically, we present a tailored penalty decomposition method that approximately solves a sequence of penalized subproblems by a block coordinate descent algorithm. To the best of our knowledge, our proposed algorithm is the first method for directly solving volatile, sparse, and mean‐reverting portfolio problems based on the portmanteau criterion and crossing statistics proxies. Further, we establish that the convergence analysis can be extended to a nonconvex objective function case if the starting penalty parameter is larger than a finite bound and the objective function has a bounded level set. Numerical experiments on the S&P 500 data set demonstrate the efficiency of the proposed algorithm in comparison to a semidefinite relaxation‐based approach and suggest that the crossing statistics proxy yields more desirable portfolios.
Evaluating color change and hydrogen peroxide penetration in human and bovine teeth through in‐office bleaching procedures
Authors: Favoreto Michael Willian , Cordeiro Deisy Cristina Ferreira , Centenaro Gabrielle Gomes , Bosco Leonardo Dal , Arana‐Gordillo Luis Alfonso , Reis Alessandra , Loguercio Alessandro D. 
Published: February 2024

AbstractObjectiveAssess color alteration and hydrogen peroxide (HP) penetration in human and bovine teeth using various in‐office bleaching protocols with different application times.Materials and MethodsThirty healthy human premolars and 30 healthy bovine incisors were divided into five groups and subjected to different bleaching protocols: 2 × 15 min, 1 × 30 min, 2 × 20 min, or 1 × 40 min, with a control group for each tooth type. All teeth were treated with 35% HP gel. Color alteration was measured using digital spectrophotometry before and 1 week after bleaching. HP concentration within the pulp was determined via UV–Vis spectrophotometry. Statistical analysis included one‐way ANOVA, Tukey's, and Dunnett's tests (α = 0.05).ResultsAll groups exhibited significant color alteration, with no statistically differences among them (p > 0.05). However, significant differences were observed when compared with their respective control groups (p < 0.05). HP penetration into the pulp was evident in all bleached teeth compared to the control groups (p < 0.05), with the 2 × 20 group showing the highest HP levels within the pulp cavity, irrespective of tooth type (p < 0.05).ConclusionA simplified 1 × 30‐min protocol can be recommended as it effectively maintains color alteration and HP penetration, irrespective of whether human or bovine teeth.Clinical SignificanceThis study suggests that an in‐office dental bleaching protocol using a 1 × 30‐min session is recommended, as it ensures both effective color change and no increase in the amount of HP penetration.
Daily age, growth rate, and pelagic larval duration of commercially important snapper species in Abrolhos National Marine Park
Authors: Silva Jeane Campos , Soeth Marcelo , Hackradt Carlos Werner , Lima Andre , Félix‐Hackradt Fabiana Cézar 
Published: February 2024

AbstractThe age and daily growth of fish are registered through the deposition of increments in their otoliths, which are concretions formed by the precipitation of substances present in the endolymphatic fluid, mainly calcium carbonate (CaCO3). Faced with the need to fill some of the gaps in the knowledge on the occurrence and duration of the initial stages of snapper species' life cycles in the Abrolhos Bank, this study aimed to describe the growth rates, age, and period of pelagic larval duration (PLD) of three snapper species during the larval pre‐settlement phase, in the Abrolhos Bank region. The post‐larvae were captured using light traps. Otoliths were removed from 117 samples of snapper species; however, only 69 were viable for age estimation, of which 15 were Lutjanus analis, 25 were Lutjanus jocu, and 29 were Lutjanus synagris. Together, the samples presented individuals with total lengths ranging from 16.14 to 24.76 mm and ages from 21 to 39 days. Settlement marks were found for all three species, and the average PLD was ~25 days. The somatic growth of the snapper species was positively correlated with otolith growth. L. jocu presented the greatest daily growth compared to the other species. The three species use the Abrolhos Bank as a larval settlement site, demonstrating plasticity by using different habitats throughout their lives.
Challenges Faced by Mothers With Visual Impairment From the Preconception Period Through the Postpartum Period
Authors: Acar Zehra , Oskay Ümran , Kula Gülcan 
Published: February 2024

IntroductionThere is a misperception in society that individuals with visual impairment are asexual and cannot marry, have children, or take care of children. In addition, individuals with visual impairment face difficulties in many aspects of life due to accessibility issues. Although it is expected that visually impaired individuals experience difficulties when having children, very few studies have focused on understanding the challenges women with visual impairment face in the process of having children. The aim of this study was to identify the challenges faced by mothers with visual impairment from preconception through the postpartum period in Turkey.MethodsSemistructured interviews were conducted with a purposive sample of 17 mothers with visual impairment. Participants were from 28 to 38 years of age, and their youngest children were 2 years old or younger. Participants were asked about their experiences with the decision to have children, pregnancy, birth, and postpartum. Content analysis was used to analyze and present the data.ResultsParticipants had 1 to 3 children and a mean age of 32.4 years. Eleven themes were identified within 4 periods: preconception, pregnancy, birth, and postpartum. Themes related to the experience of the preconceptional period included concern about the decision to have a child and the social pressure on the decision to have a child. Themes related to the experience of pregnancy included inaccessible pregnancy tests, emotional reactions to pregnancy, dissatisfaction with health care providers, and unmet expectations. Themes related to labor and birth included mixed feelings about labor dissatisfaction with health care providers and unmet expectations. Themes related to the postpartum period included personal care, infant care, reaction of the social network, and unmet expectations.DiscussionThe mothers with visual impairment faced many challenges in the process of becoming a parent. Mothers expressed the need for accessible health services from institutions and health professionals.
Overconfidence and Preferences for Competition
Authors: REUBEN ERNESTO , SAPIENZA PAOLA , ZINGALES LUIGI 
Published: February 2024

ABSTRACTWe study when preferences for competition are a positive economic trait among high earners and the extent to which this trait can explain the gender gap in income among a master's degree in business administration (MBAs). Consistent with the experimental evidence, preferences for competition are a positive economic trait only for individuals who are not overconfident. Preferences for competition correlate with income only at graduation when bonuses are guaranteed and not a function of performance. Overconfident competition‐loving MBAs observe lower compensation and income growth, and experience greater exit from high‐reward industries and more frequent job interruptions. Preferences for competition do not explain the gender pay gap among MBAs.