bluuebunny/crossref_metadata_2025_split huggingface dataset:
No morphological connections between L2 past-tense and present-tense verbs for low-proficient bilinguals: Evidence from masked priming
Authors: Wanner-Kawahara Jessie , Yoshihara Masahiro , Lupker Stephen J. , Verdonschot Rinus G. , Nakayama Mariko 
Published: January 2025

Aims and objectives: Masked priming lexical decision research involving relatively high-proficient Japanese–English bilinguals suggests that past-tense and present-tense morphological connections (e.g., fell-FALL and looked-LOOK) are represented in their L2 (English) lexicons in a way that is similar to how they are represented in L1 (English) lexicons. The goal of the present research was to determine whether the same is true for low-proficient Japanese–English bilinguals. Methodology: Seventy-seven low-proficient Japanese–English bilinguals were tested in the masked priming lexical decision task. We manipulated the morphological or orthographic similarity between L2 English prime-target pairs. Data and analysis: We analyzed response latencies and error rates using (generalized) linear mixed-effects models. Findings: Although participants responded significantly faster to targets preceded by past-tense primes (e.g., fell-FALL and looked-LOOK) when compared to unrelated primes (e.g., slow-FALL and danger-LOOK), those priming effects were the same size as priming effects produced by orthographically similar primes (e.g., fill-FALL and lonely-LOOK), suggesting that the facilitation from past-tense primes is likely orthographic in nature. Nevertheless, the low-proficient bilinguals showed significant L2-L2 repetition priming (e.g., fall-FALL and look-LOOK), suggesting that, for those individuals, L2 (English) words are at least represented at the lexical level. Originality: The present study empirically confirmed a prediction, derived from a post hoc exploratory analysis in our previous research, that masked morphological priming effects are no larger than orthographic priming effects in low-proficient bilinguals. This indicates that a certain level of functional proficiency is required to observe morphological priming effects for Japanese–English bilinguals. Implications: Our results suggest that morphological connections in L2 are not yet established for low-proficient bilinguals, even when L2 words are lexically represented in their mental lexicon.
Bambusa vulgaris Extract: A Potential Natural Biogenic Amine Neurotransmitters Modulator, COX-2 Inhibitor and Oxidative Species Suppressor for Managing Depression and Anxiety
Authors: Murtala Akanji A. , Oyinloye Elijah O. , Oladoja Farouk A. , Fageyinbo Samuel M. , Olasore Holiness S.A , Ogunjimi Luqman O. , Alabi Akinyinka O. , Olooto Wasiu E. , Soyinka Oluwatosin O. , Faponle Abayomi S. , Shonde Oluwatoyin O. , Osipitan Luqmon E. , Joseph Olusola O. , Oderinde Ifeoluwa A. , Onifade Onaolapo R. 
Published: January 2025

Objective Literature reveals a significant deficiency in scientific investigations regarding the use of Bambusa vulgaris extract (BVE) for the treatment of neuropsychiatric disorders, particularly those characterized by anxiety and depression. Thus, this study was designed to examine the anxiolytic and antidepressant-like properties of BVE using mouse models, while also elucidating the potential underlying mechanisms responsible for the observed antidepressant effects of the extract. Methods Validated behavioral assessments were employed to assess the anxiolytic effects (including the hole-board test (HBT), open field test (OFT), elevated plus maze test (EPMT), and light/dark exploration test (LDET)) as well as the antidepressant effects (comprising the forced swim test (FST) and tail suspension test (TST)) of the extract. Chronic mild stress paradigms were employed to induce depressive-like behaviors in the mouse subjects. The mice were administered treatments consisting of distilled water (10 mL/kg; serving as a negative control), fluoxetine (20 mg/kg; standard drug), and BVE (at varying doses of 100, 200, and 400 mg/kg). The concentrations of biogenic amine neurotransmitters (noradrenaline and serotonin) and cyclooxygenase-2 (COX-2) within the brain were measured using ELISA kits. Antioxidant biomarkers were assessed through the application of standardized commercial assay kits. Results BVE significantly diminished anxiety levels in mouse subjects, as demonstrated by an enhancement in exploratory activities in the light/open enclosures and an increased aversion to darker compartments. Furthermore, BVE significantly alleviated depression-like behaviors in mice, which was reflected by an increased latency to immobility and a reduction in the overall duration of immobility. BVE enhanced noradrenaline and serotonin neurotransmission, suppressed oxidative species, and inhibited COX-2 activity. Conclusion The results obtained from this study suggest that BVE demonstrates anxiolytic and antidepressant properties, the latter being mediated through the enhancement of biogenic amine neurotransmitters (noradrenaline and serotonin), inhibition of COX-2 activity, and suppression of oxidative radicals within the brain.
Macrofocal multiple myeloma in the era of novel agents in China
Authors: Dou Xuelin , Liu Ruixia , Liu Yang , Peng Nan , Wen Lei , Deng Daoxing , Cao Leqing , Li Qian , Wang Liru , Wang Fengrong , Mo Xiaodong , Lu Jin 
Published: January 2025

Background: Macrofocal multiple myeloma (MFMM) is characterized by clonal plasma cells comprising less than 20% of the bone marrow, multiple lytic bone lesions, and the absence of anemia, renal insufficiency, and hypercalcemia. This subtype of multiple myeloma (MM) has a relatively low incidence. Prognostic staging and cytogenetic guidance for MFMM are often insufficient due to the low tumor burden in the bone marrow. Large cohort studies on this subgroup during the era of novel agents are limited. Objectives: We aim to describe the clinical characteristics and prognostic markers of MFMM patients undergoing treatment with novel agents. Methods: Consecutive cases of MM patients diagnosed at Peking University People’s Hospital and Fu Xing Hospital of Capital Medical University from 2011 to 2023 were screened. A propensity score matching was conducted with a 2:1 ratio, matching classic MM patients to MFMM patients based on clinical variables of age and year of diagnosis. Results: We identified 91 cases (4%) of MFMM and 182 matched classic MM among 2291 MM patients. The MFMM cohort had a higher proportion of male patients, those with <90% clonal plasma cells in the bone marrow by multiparameter flow cytometry, and patients with extramedullary disease, along with a lower proportion of patients with high-risk cytogenetics or advanced disease staging. MFMM patients demonstrated better overall responses compared to the control cohort ( p = 0.027) in those not receiving upfront autologous stem cell transplantation (ASCT). During a median follow-up of 42.8 months for the entire cohort, the MFMM cohort exhibited significantly superior progression-free survival (PFS) and overall survival (OS) compared to the control cohort. In multivariate analysis of the entire cohort, exposure to immunomodulatory drugs and ASCT consolidation in frontline therapy were independently associated with improved PFS and OS. For the MFMM cohort, a Ki-67 index ⩾20% was associated with inferior PFS, providing valuable prognostic information in a group where staging and cytogenetic guidance are often inadequate. Conclusion: We concluded that treatment strategies for MFMM patients should align with those for standard MM, and a Ki-67 index ⩾20% in biopsy samples of plasmacytoma is associated with inferior PFS.
Perioperative Dysphagia Considerations for Patients With Severe Cervical Spondylotic Myelopathy
Authors: Ohba Tetsuro , Tanaka Nobuki , Oda Kotaro , Katsu Marina , Takei Hayato , Go Goto , Akaike Hiroshi , Haro Hirotaka 
Published: January 2025

Study Design Cohort study with consecutive cases. Objectives Dysphagia after anterior cervical spine surgery is a well-known complication. The aim of this study is to identify risk factors for dysphagia in patients with cervical myelopathy requiring surgery. Methods We conducted a prospective analysis of 92 consecutive patients with cervical spondylotic myelopathy (CSM) who underwent anterior cervical spine surgery. All patients underwent a pre- and postoperative swallowing evaluation using the Eating Assessment Tool (EAT-10) and the Hyodo–Komagane (H‒K) score, an endoscopic scoring method used by an examining otolaryngologist to assess dysphagia. Results None of the patients had dysphagia when assessed using EAT-10; however, 15.2% of patients had H‒K scores indicative of dysphagia. Preoperative latent dysphagia was highly correlated with postoperative dysphagia (r = 0.51, P < 0.0001). No significant difference was found for the presence of dysphagia due to a history of smoking, dialysis, diabetes, asthma, and restrictive and/or obstructive ventilation disorder. The 10-s grip and release test ( P < 0.0001) and the upper extremity function ( P = 0.004) and bladder function ( P = 0.0008) items from the Japanese Orthopaedic Association scores significantly correlated with H‒K scores. Conclusion This study suggests that advanced age and severe preoperative upper limb and bladder dysfunction are risk factors for dysphagia in patients with cervical myelopathy requiring surgery.
Analysis of postoperative atrial fibrillation and its associated factors in Morrow procedures with cardiopulmonary bypass
Authors: Hu Zhibin , Mao Wenshuai , Guo Lijun , Liu Zhiwei , Hu Xujie , Cui Yong 
Published: January 2025

Abstract

Background
The factors influencing the onset of new atrial fibrillation following the Morrow procedure due to cardiopulmonary bypass (CPB) are unclear. This study investigated the CPB-related factors associated with postoperative atrial fibrillation (POAF) in patients undergoing minimally invasive ventricular septal myectomy (Morrow procedure) to optimize CPB strategies, reduce the incidence of POAF, and enhance recovery.

Methods
A retrospective clinical data analysis was conducted on 139 patients who underwent minimally invasive Morrow procedures from January to December 2023. The patients were divided into two groups based on whether they developed new-onset atrial fibrillation after surgery, and a comparative study was performed. Multivariate regression analysis were used to assess factors potentially influencing POAF during CPB.

Results
Fifty (36%) patients developed POAF. Comparisons between the POAF group and the non-POAF group revealed significant differences in preoperative hypertension (38.0% vs. 14.6%, p = 0.002), ischaemic cardiomyopathy (40.0% vs. 20.2%, p = 0.012), history of heart failure (44.0% vs. 22.5%, p = 0.008), age (55.16 ± 14.11 vs. 46.28 ± 14.55, p = 0.001), the preoperative systemic immune-inflammation index (SII) (418.26 ± 243.97 vs. 330.24 ± 152.89, p = 0.019), the left atrial volume index (LAVI) (36.79 ± 12.08 vs. 32.24 ± 10.78, p = 0.024), CPB time (129.80 ± 39.58 vs. 116.96 ± 28.80, p = 0.027), CPB weaning time (25.68 ± 22.56 vs. 19.49 ± 6.78, p = 0.018), rate of re-CPB (14.0% vs. 3.4%, p = 0.020), rate of ultrafast-track cardiac anesthesia (UFTCA) (78.0% vs. 98.9%, p = 0.000), and ΔSII (2874.58 ± 2865.98 vs. 1981.85 ± 1519.89, p = 0.006) (P < 0.05). All patients were discharged, but the ICU (2.07 ± 2.91 vs. 1.38 ± 0.78, p = 0.046) and postoperative hospital stays (11.84 ± 7.50 vs. 9.13 ± 2.62, p = 0.002) were significantly prolonged. The results of the multivariate logistic regression analysis indicated that the occurrence of POAF was independently associated with age (OR = 1.047, 95% CI: 1.015–1.080), ΔSII(OR = 13.317, 95% CI: 3.103–57.154) and UFTCA(OR = 0.054, 95% CI: 0.006–0.493) (p < 0.05). Additionally, the increased value of SII was independently associated with CPB weaning time (t = 2.493, p = 0.014) and age(t=-2.270, p = 0.025).

Conclusion
UFTCA is a protective factor against POAF. Age and ΔSII are risk factors for the occurrence of POAF after the Morrow procedure. CPB weaning time and Age are significant influencing factors of ΔSII. Implementing UFTCA and shortening the CPB weaning time are expected to lower the risk of POAF, shorten ICU and hospital stays, and enhance recovery.

Clinical trial number
Not applicable.
Exploring the assessment of post-cardiac valve surgery pulmonary complication risks through the integration of wearable continuous physiological and clinical data
Authors: Li Lixuan , Hu Yuekong , Yang Zhicheng , Luo Zeruxin , Wang Jiachen , Wang Wenqing , Liu Xiaoli , Wang Yuqiang , Fan Yong , Yu Pengming , Zhang Zhengbo 
Published: January 2025

Abstract

Background
Postoperative pulmonary complications (PPCs) following cardiac valvular surgery are characterized by high morbidity, mortality, and economic cost. This study leverages wearable technology and machine learning algorithms to preoperatively identify high-risk individuals, thereby enhancing clinical decision-making for the mitigation of PPCs.

Methods
A prospective study was conducted at the Department of Cardiovascular Surgery of West China Hospital, Sichuan University, from August 2021 to December 2022. We examined 100 cardiac valvular surgery patients, where wearable technology was utilized to collect and analyze nocturnal physiological data at the 24-hour admission, in conjunction with clinical data extraction from the Hospital Information System’s electronic records. We systematically evaluated three different input types (physiological, clinical, and both) and five classifiers (XGB, LR, RF, SVM, KNN) to identify the combination with strong predictive performance for PPCs. Feature selection was conducted using Recursive Feature Elimination with Cross-Validated (RFECV) for each model, yielding an optimal feature subset for each, followed by a grid search to tune hyperparameters. Stratified 5-fold cross-validation was used to evaluate the generalization performance. The significance of AUC differences between models was tested using the DeLong test to determine the optimal prognostic model comprehensively. Additionally, univariate logistic regression analysis was conducted on the features of the best-performing model to understand the impact of individual feature on PPCs.

Results
In this study, 22 patients (22%) developed PPCs. Across classifiers, models combining both physiological and clinical features performed better than physiological or clinical features alone. Specifically, including physiological data in the classification model improved AUC, ACC, F1, and precision by an average of 8.32%, 1.80%, 3.28% and 6.06% compared to using clinical data only. The XGB classifier, utilizing both dataset, achieved the highest performance with an AUC of 0.82 (± 0.08) and identified eight significant features. The DeLong test indicated that the XGB model utilizing the both dataset significantly outperformed the XGB models trained on the physiological or clinical datasets alone. Univariate logistic regression analysis suggested that surgical methods, age, nni_50, and min_ven_in_mean are significantly associated with the occurrence of PPCs.

Conclusion
The integration of continuous wearable physiological and clinical data significantly improves preoperative risk assessment for PPCs, which helps to optimize surgical management and reduce PPCs morbidity and mortality.
Validity of patient-reported information: agreement rate between patient reports and registry data
Authors: Watanabe Tomone , Ichinose Yuichi , Toida Tsutomu , Higashi Takahiro 
Published: January 2025

Abstract

Background
The accuracy of patient-reported clinical information, including cancer stage, is not well understood. This study aims to evaluate the agreement between patient-reported survey data and clinical information recorded in hospital-based cancer registries (HBCR).

Methods
A total of 730 patients from 166 hospitals in Japan were randomly selected and informed that their survey responses would be validated against HBCR data. Demographic details, including age, sex, cancer stage, and cancer site, were recorded and compared with clinical data from the HBCR. Agreement rates between patients’ self-reported demographic and clinical data and the corresponding HBCR records were analyzed. Logistic regression analysis was conducted to identify factors associated with accurate reporting of cancer stage information.

Results
Agreement rates for age, sex, and cancer site were 99.4%, 99.8%, and over 90% across all cancer sites, respectively. The agreement rate for cancer stage reporting was 49.9%. Patients with stage IV cancer had the highest agreement rate at 68.4%. Patients under 75 years of age and those with specific cancer types demonstrated higher odds of reporting data consistent with HBCR records.

Conclusions
For cancer stage data, relying on more credible sources, such as cancer registries, is recommended over patient-reported information to ensure accuracy.
Implementation of rural provider-to-provider telehealth in country Western Australia: a retrospective observational analysis via the RE-AIM framework
Authors: Toll Kaylie , Robinson Suzanne , Andrew Stephen , Williams Aled , Yeung Justin , Varhol Richard , Moullin Joanna C. 
Published: January 2025

Abstract

Background
Rural provider-to-provider telehealth is growing globally. It is used to both facilitate equitable access to specialist healthcare services for those living in rural and remote areas and provide support to place-based providers. There is limited research on the implementation of these services, especially in an emergency or inpatient hospital setting. The Western Australia Country Health Service (WACHS) Command Centre is one such example. First implemented in 2012, the Command Centre services a geographical area covering 2.55 million square kilometres, a population of approximately 550,000, and provides five clinical streams including Emergency, Mental Health Emergency, Midwifery and Obstetrics Emergency, Inpatient, and Palliative Care Afterhours Telehealth Services.

Objectives
This study aimed to evaluate the implementation and access of rural provider-to-provider telehealth in country Western Australia, for the years 2012 to 2023.

Methods
A retrospective observational analysis was conducted of all patient contacts managed by clinical telehealth streams of the Command Centre, between 31 August 2012 and 31 December 2023. Utilising descriptive statistics, analyses was informed by the expanded Reach, Effectiveness, Adoption, Implementation, Maintenance (RE-AIM) Framework and Implementation Outcomes Framework (IOF) definitions.

Results
Over the near 12-year period, a total of 215,965 service contacts were analysed from the five Command Centre clinical streams. There was large variation in the reach and adoption of services across regions, sites, and health facility types, however service scope and activity has increased steadily over time (maintenance). 95 of the 103 WACHS-managed sites had utilised Command Centre clinical telehealth services. The Command Centre has seen an increase in the proportion of clinical telehealth services provided to the most disadvantaged populations, demonstrating improved equity of access (effectiveness) over time.

Conclusion
There is a steady expansion in the availability of provider-to-provider clinical telehealth services delivered by the WACHS Command Centre across country WA, but with wide variability of usage depending on region, site, and health facility type. The results of this study show there is a need to understand the contextual factors influencing the adoption, implementation, and sustainability of the service.
Effectiveness of a training program for the acquisition of motor milestones in infants: a randomized clinical trial
Authors: Fernández-Sola Luis , Cano-Díez Beatriz , Pons-Solaz Yessica , Vera-Egido Begoña , Moreno-González Sergio 
Published: January 2025

Abstract

Background
In infants, the acquisition of all motor milestones is considered an expression of correct motor development during the first months of life. An association between typical motor development of the newborn and cognitive areas has been established. Few studies have evaluated the efficiency of parents’ knowledge of expected milestones in healthy infants.
This study aims to determine whether parents’ knowledge of specific tasks can improve the achievement of all gross motor milestones in the newborn.

Method
The current study examined gross motor development in term-born infants without pathologies at 9, 12, and 15 months and the effectiveness of a training program developed for parents. The research group comprised 82 full-term infants divided into an experimental group (EG) and a control group (CG) of 41 subjects each. A randomized clinical trial study was performed. The routine follow-up program consisted of four informative sessions on the experimental group at the beginning of each trimester with information about the expected motor milestones and how to stimulate their infants to achieve them. The gross motor development of the participants was measured using the Alberta Infant Motor Scale. An ANCOVA test was performed to assess the possible influence of sex, type of birth, or the presence of siblings controlled and uncontrolled as confounding variables on the results.

Results
The initial baseline assessment showed no statistical differences between groups (p > 0,05). After controlling confounding variables, at 9 months the EG scored 5,5 points higher than the CG (p < 0,001). At 12 months, EG scored 3,7 points higher than CG (p < 0,001). At 15 months, EG scored 2,2 points higher than CG (p = 0,001).
The experimental group scored significantly higher, with a 25-point higher percentile in each assessment.

Conclusion
A learning program aimed at increasing parents’ knowledge of their infant´s gross motor development improved it. The information collected will help professionals who support parents in monitoring their babies.
Future studies using larger sample sizes, analysing other domains of global infant development, or investigating the possible influence of other parental factors are recommended.

Trial registration
ClinicalTrials.gov ID NCT04693494. Registered December 28, 2020, retrospectively registered. https://clinicaltrials.gov/study/NCT04693494.