bluuebunny/crossref_metadata_2025_split huggingface dataset:
Managing Resource Utilization Cost of Laboratory Tests for Patients on Chemotherapy in Johns Hopkins Aramco Healthcare
Authors: Ahmed Huda Al-Sayed , Al-Faris Nafeesa A. , Sharp Joshua W. , Abduljaber Issam O. , Ghaida Salam S. Abou 
Published: November 2023

ABSTRACT

Introduction
Laboratory testing is a fundamental diagnostic and prognostic tool to ensure the quality of healthcare, treatment, and responses. This study aimed to evaluate the cost of laboratory tests performed for patients undergoing chemotherapy treatment in the oncology treatment center at Johns Hopkins Aramco Healthcare in Saudi Arabia. Additionally, we aimed to reduce the cost of unnecessary laboratory tests in a 1-year period.

Methods
This was a quality improvement study with a quasi-experimental design using DMAIC methodology. The intervention strategy involved educating staff about adhering to the British Columbia Cancer Agency (BCCA) guidelines when ordering laboratory tests for chemotherapy patients, then integrating those guidelines into the electronic health record system. Data were collected for 200 randomly selected cases with 10 different chemotherapy protocols before and after the intervention. A paired t test was used to analyze differences in mean cost for all laboratory tests and unnecessary testing before and after the intervention.

Results
A significant cost reduction was achieved for unnecessary laboratory tests (77%, p &lt; 0.01) when following the BCCA guidelines. In addition, the mean cost of all laboratory tests (including necessary and unnecessary) was significantly reduced by 45.5% (p = 0.023).

Conclusion
Lean thinking in clinical practice, realized by integrating a standardized laboratory test guided by BCCA guidelines into the electronic health record, significantly reduced financial costs within 1 year, thereby enhancing efficient resource utilization in the organization. This quality improvement project may serve to increase awareness of further efforts to improve resource utilization for other oncology treatment protocols.
An Analysis Of Students’ Difficulties In Writing Hortatory Exposition Text At Eleventh Grade Of SMA TAMAN SISWA Pematangsiantar
Authors: Purba Anita , Putri Aprilia Kinanti  
Published: November 2023

The purpose of this research are to know: 1) The students’ ability in writing Hortatory exposition text at the eleventh grade students of SMA Taman Siswa Pematang siantar in 2021/2022 academic year 2) The difficulties that faced by the students’ in writing Hortatory exposition text at the eleventh grade students of SMA Taman Siswa Pematang siantar in 2021/2022 academic year. This research is used mixed method that is combination of qualitative and quantitative research. This is research was done by using documentation and students text essay hortatory exposition text. The informants of this research are 66 that representative from the eleventh grade students. The data were collected used randomly sampling. Test was made to know the students’ ability in writing Hortatory exposition text and the difficulties that faced by the students’ in writing Hortatory exposition text ability at the eleventh grade, observation was made to know all of the activities or behaviours of the students’ in writing Hortataory exposition text. The highest score 75, the lowest score 38, and the average score in writing Hortatory exposition text 57.33 and it was categorized difficult, it means that students ability in writing Hortatory exposition text are still difficult. The students had difficulty in using content 80%, using organization 73.33%, using vocabulary 73.33%, mastering grammar 93.33%, and using mechanics 20%. It means that the students need to learn more about Hortatory exposition text.while the students difficulties in writing was language features and generic structure of hortatory exposition text consist of thesis and arguments, lack vocabulary and grammar mastery so majority of students was difficult to create the sentences and write correct spelling words, based on the result, the researcher taken a conclusion that the students have not understanding in writing hortatory exposition text
The Effectiviness Of Applying KWL (Know, Want, Learn) Strategy On Reading Comprehension At SMP NEGERI 4 Pematangsiantar
Authors: Indra Jayanti  , Nasution Yunita Karnelia 
Published: November 2023

The aim of this research was to find out the effect of KWL strategy on the reading comprehension of the eight grade students at SMP NEGERI 4 PEMATANGSIANTA in the academic year of 2021/2022. This research was conducted on May 2022. This research was classified as a true-experimental study. It involved 64 students from two groups, class VIII5 (32 students) as the experimental group and VIII6 (32 students) as the control group. The experimental group was students taught using KWL strategy where as the control group was students taught using contial technique . The data were obtained by using pre-test and post-test. The data of the pre-test and post-test of both groups were analyzed by using descriptive and inferential statistic. (SPSS 22.0). The result of the research shows that the testing hypothesis of post-test score, it is found that tcount (8.63) > ttable (1.67) at the significance level a = 0.05 and degrees of freedom (df) = 63. H0 is rejected and Ha is accepted. So, it means that the KWL strategy effect significantly to improve students’ reading comprehension at the eight grade of SMP Negei 4 Pematangsiantar academic year of 2021/2022.
PENINGKATAN KAPASITAS UMKM DENGAN MENUMBUHKAN JIWA WIRAUSAHA YANG KREATIF DAN INOVATIF DI KABUPATEN LUWU
Authors: Latief Fitriani , Hidayat Muhammad , Firman Ahmad , Z Nurhaeda , Dwinanda Giri 
Published: November 2023

Kewirausahaan merupakan salah satu faktor pendorong peningkatan perekonomian Indonesia. Kewirausahaan melalui Usaha Mikro Kecil Menengah (UMKM) diharapkan dapat meningkatkan kreatifitas dan kemampuan masyarakat dalam menyalurkan ide dan kreasinya dengan memanfaatkan sumber daya alam yang tersedia. Usaha Mikro Kecil Menengah (UMKM) di Indonesia merupakan salah satu soko guru perekonomian Indonesia selain koperasi. Salah satunya adalah pelaku UMKM di Kabupaten Luwu yang masih memiliki kendala mengembangkan kreatifitasnya dalam pengembangan UMKM. Tujuan penelitian ini adalah untuk menumbuhkan jiwa wirausaha yang kreatif dan inovatif yang dapat mendukung keberhasilan usaha pelaku UMKM. Metode yang digunakan dalam melaksanakan kegiatan ini adalah dengan melakukan seminar, diskusi dan pelatihan atau workshop. Dari kegiatan penelitian ini Masyarakat utamanya pelaku UMKM dapat mengembangkan dan mengimplementasikan kreatifitasnya dan inovatif dalam bisnis dengan mengoptimalkan skill yang dimiliki dengan mengubah tantangan menjadi peluang dengan harus memiliki komitmen yang tinggi dari seorang wirausahawan.
Édouard Petit, un haut fonctionnaire républicain (1858-1917) et sa conception de l’éducation populaire
Authors: Martin Jean-Paul 
Published: November 2023

L’article attire d’abord l’attention à partir d’archives inédites ou peu connues sur l’itinéraire et la personnalité d’Édouard Petit (1858-1917), juif d’origine méridionale, professeur de l’enseignement secondaire devenu inspecteur général de l’enseignement primaire, journaliste et écrivain, dirigeant de la Ligue de l’enseignement et de la mutualité, chargé de superviser l’éducation populaire laïque au moment où celle-ci devient un enjeu d’importance pour la IIIe République. Dans un second temps, il tente de reconstituer quelques éléments centraux de la vision de l’éducation populaire propagée par Édouard Petit autour du lien avec l’école, à travers trois approches successives. La première se situe au niveau des modèles pédagogiques ; elle insiste sur l’attraction du modèle scolaire au sein des œuvres péri et post-scolaires, mais aussi sur la capacité d’innovation de celles-ci, le tout conduisant à faire de l’éducation populaire une sorte d’« école idéale ». La seconde se focalise sur le rôle stratégique dévolu au corps enseignant primaire, ce qui aboutit tant à travers le discours officiel du dévouement volontaire que des désirs d’autonomisation des acteurs, à faire émerger la figure durable de l’instituteur-militant. Enfin, la troisième approche met en évidence le lien entre l’éducation populaire et la réforme de l’enseignement, que résume l’idée d’obligation post-scolaire ; elle questionne pour finir l’échec de cette idée aussi bien dans le « moment Édouard Petit » qu’au cours des périodes suivantes marquées par l’émergence de la thématique de l’école unique et de la démocratisation de l’enseignement.
Multichannel intraesophageal impedance with pH metry in Saudi children
Authors: Mouzan Mohammad El , Naqeeb Ahlam Al , Otaibi Najla Al , Askar Jawaher Al , Joseph Teema , Sarkhy Ahmed Al , Asmi Mona Al , Assiri Asaad 
Published: November 2023

Abstract

Background:
Multichannel Intraesophageal Impedance with pH (MII-pH) provides complete characterization of gastroesophageal reflux (GER). The aim of this study was to report our experience in this relatively new technique, emphasizing the challenges in the performance and interpretation of the results.

Methods:
The study was conducted at King Khalid University Hospital at King Saud University in Riyadh. A retrospective review of the medical records of children who underwent MII-pH was performed. The procedure was performed and interpreted according to the recommended methodology. The impedance catheter was introduced nasally. The use of event markers and diary were explained to the accompanying person. At the end of the recording, the data were downloaded to the software analysis system.

Results:
MII-pH was performed on 98 children, and 16 studies were excluded from analysis for technical reasons. The median age was 32 (range 2–168) months and 44 (54%) were male. The prevalence of nonacid gastroesophageal reflux (NAGER), proximal extent of GER, and postprandial NAGER were 55%, 50%, and 70%, respectively. One hundred and fifty-three symptoms were reported during the study, but only two were significant.

Conclusion:
The MII-pH was well-tolerated but the performance and interpretation were technically demanding. The main advantage was the detection of NAGER. However, the lack of normal values and the reliance on symptom association make the interpretation of the results challenging.
Metabolomics in chronic hepatitis C: Decoding fibrosis grading and underlying pathways
Authors: Ferrasi Adriana Camargo , Lima Samara Vitória Granja , Galvani Aline Faria , Delafiori Jeany , Dias-Audibert Flavia Luísa , Catharino Rodrigo Ramos , Silva Giovanni Faria , Praxedes Roberta Rodrigues , Santos Driele Bretones , Almeida Dayane Trevisan de Macedo , Lima Estela Oliveira 
Published: November 2023

BACKGROUND
Chronic Hepatitis C (CHC) affects 71 million people globally and leads to liver issues such as fibrosis, cirrhosis, cancer, and death. A better understanding and prognosis of liver involvement are vital to reduce morbidity and mortality. The accurate identification of the fibrosis stage is crucial for making treatment decisions and predicting outcomes. Tests used to grade fibrosis include histological analysis and imaging but have limitations. Blood markers such as molecular biomarkers can offer valuable insights into fibrosis.
AIM
To identify potential biomarkers that might stratify these lesions and add information about the molecular mechanisms involved in the disease.
METHODS
Plasma samples were collected from 46 patients with hepatitis C and classified into fibrosis grades F1 (n = 13), F2 (n = 12), F3 (n = 6), and F4 (n = 15). To ensure that the identified biomarkers were exclusive to liver lesions (CHC fibrosis), healthy volunteer participants (n = 50) were also included. An untargeted metabolomic technique was used to analyze the plasma metabolites using mass spectrometry and database verification. Statistical analyses were performed to identify differential biomarkers among groups.
RESULTS
Six differential metabolites were identified in each grade of fibrosis. This six-metabolite profile was able to establish a clustering tendency in patients with the same grade of fibrosis; thus, they showed greater efficiency in discriminating grades.
CONCLUSION
This study suggests that some of the observed biomarkers, once validated, have the potential to be applied as prognostic biomarkers. Furthermore, it suggests that liquid biopsy analyses of plasma metabolites are a good source of molecular biomarkers capable of stratifying patients with CHC according to fibrosis grade.
Efficiency of the oestrus synchronization with hand mating and artificial insemination on the reproductive performances of Woyto-Guji Goat under community-based breeding program
Authors: Dea Dereje , Eramo Ermias , Seid Anwar 
Published: November 2023

The present study was designed to describe the efficiency of oestrus synchronization on Woyto-Guji goats under community-based breeding program in Konso zone. Single and double injections of PGF2α followed by AI and single injection followed by buck mating were the protocols applied. Percent responded, inseminated, conceived, delivered, aborted, time of insemination, gestation length and litter size were data collected for the experiment. A total of 177 does were used for oestrus synchronization by using PGF2α hormone. Overall, the findings revealed that about 88.14% of the does expressed oestrus within 57.48±2.64 hours after hormone administration. The overall percent inseminated, conceived, delivered and aborted and gestation length (day) were 91.67, 93.71, 72.03, 2.82%, and 152.48±2.34, respectively. The overall percent of kid sex born was about 51% female and 49% male, and litter size was about 58% single and 42% twin. The response rate was significantly affected by age (P<0.05). Percent inseminated, conceived, kid delivered and time of insemination were significantly affected by protocol, parity and age (P<0.05). Buck mating on hormone treated does was relatively easily applicable for increased conception rate under the community level.
Epidemiological Study of Malaria Infection among Pregnant Women in Gombe, Gombe State, Nigeria
Authors: Pindar W. , Chessed G. , Manu J. M. 
Published: November 2023

Malaria is one of the most devastating diseases plaguing mankind. The disease is endemic in tropical and sub-Saharan Africa of which Nigeria belongs. The Epidemiological study of malaria infection among pregnant women was carried out on 1,521 patients reporting for their first antenatal clinic in hospitals and clinics, in Gombe, Gombe State, Nigeria. Giemsa stained thick and thin films for malaria parasite test was carried out on the women, alongside obtaining information on their socio-demographic characteristics. Most of our participant were in the age group 21-30 years (56.34%), while most of them had their secondary education (49.85%) and were housewives 99.41%. The prevalence of malaria was 8.48%, with the 21-30 year old age group having the highest prevalence of malaria (56.34%). The highest prevalence of malaria was among those in their second trimester (11.48%), while those with more than seven children had the highest prevalence of malaria (25.00%). The highest prevalence of malaria was seen among those with non-formal education (11.30%), housewives (8.44%) and the single pregnant women (22.22%). The prevalence of malaria was statistically significant with age group and occupation. We advise that measures encouraging personal and environmental hygiene, use of prophylactic drugs and sleeping under treated mosquito nets should be encouraged to reduce the prevalence of malaria among the pregnant women.
Assessment of Heavy Metals Content of Hand Dug Wells in Shasha Market, South Western, Nigeria
Authors: Ojo O. M. 
Published: November 2023

The presence of heavy metals in potable water can cause serious health issues when consumed by humans. Hence, the objective of this paper is to assess the of heavy metals content of hand dug wells in Shasha market, Akure, South Western Nigeria were analyzed. The presence of five (5) heavy metals namely Zinc (Zn), Iron (Fe), Manganese (Mn), Cadmium (Cd) and Chromium (Cr) in the water samples were analyzed in the laboratory. Atomic Absorption Spectrometry was used in the heavy metal analysis. The Zn, Fe and Mn contents of the water samples fell within WHO standard for potable water. However, the study revealed Cd contamination in 100% of the water samples analyzed with a range of 0.005 mg/L to 0.013 mg/L as against the WHO maximum permissible limit of 0.003 mg/L for potable water. The results revealed that the concentrations of Cr in all the samples analyzed ranged between 0.021 and 0.10 mg/L with only 20% of the well water samples analyzed having values above the WHO Cr maximum permissible limit of 0.05 mg/L for potable water. Even though the Zn, Fe and Mn contents of the water samples fell within WHO standard for potable water, adequate treatment is required for all the well water samples before human consumption.
Assessment of Groundwater Quality by Heavy Metal Pollution Index in Ijare Rural Community and Alagbaka Urban Area in Ondo State, Nigeria
Authors: Aluko R. T. , Ojo O. M. , Olabanji T. O. , Ojo T. J. 
Published: November 2023

Groundwater is becoming an essential source of water supply in many locations, and assessment of groundwater quality is essential to trace out the major groundwater contaminants. In this study, Ijare represents a rural land use and Alagbaka representing the urban land use. The objective of this paper is to assess the groundwater quality by heavy metal pollution index (HMPI) in Ijare rural community and Alagbaka urban area in Ondo State, Nigeria using a 210VGP atomic absorption spectrophotometer. Data obtained reveals that, the concentration of iron in wells ranged between 0.1335 and 0.2715mg/L, Chromium in the study areas had levels ranging from 0.056 to 0.1615mg/L, while the levels of manganese ranged between 0.0775 and 0.1725mg/L and that of Lead had levels was between 0.01 to 0.11mg/L. This study thus reveals that the concentration of iron was within the WHO drinking water standard limit of 0.3mg/L, chromium in the study areas had levels above the WHO drinking water standard limit of 0.05mg/L, manganese levels within the WHO drinking water standard limit of 0.4mg/L and Lead had levels above the recommended limit.
Evaluation of Natural Fertilizer Potential of Neem Leaves Aqueous Extract for Irrigation Practices
Authors: Mohammed K. A. , Balogun O. S. , Adebayo K. R. 
Published: November 2023

A natural fertilizer relies on plant, mineral and animal sources for its nutrients. The objective of this paper is to evaluate the natural fertilizer potential of Neem leaves aqueous extract for irrigation practices by analyzing some physicochemical parameters using standard methods. Data obtained shows that the pH level were, 8.4, 7.2, 7.1, and 7.3 respectively indicating a moderate alkalinity status suitable for irrigation. The electrical conductivity values were as 2.4, 2.2, and 1.8 mg/L for Neem aqueous extract while turbidity values were 334, 323, and 296 NTU respectively .These values are within the acceptable range according to FAO guidelines. SAR values were as 11.20, 10.04, and 10.81 and chloride levels were found to be; 22.1, 16.12, and 5.97 mg/L, posing no concerns for irrigation. Sodium levels were 35.7, 27.32 and 25.31 mg/L which also falls within the FAO guidelines and indicating moderate sodicity. Overall, the nutritional compositions of the Neem leaf extracts were within the FAO guideline limits for irrigation fluid, indicating their suitability for irrigation practices. This Neem leaf extract as an irrigation solution could provide a valuable insights for farmers and agricultural practitioners seeking to optimize crop productivity and quality.
Effect of Raw Leachate on Gills and Liver of Juvenile African catfish (Clarias gariepinus)
Authors: Oduh O. , Wilfred O. , Okure V. U. 
Published: November 2023

The effect of toxicity of raw leachate obtained from dumpsites on Clarias gariepinus (C. gariepinus) (n = 6) was studied under laboratory conditions with the aim of establishing its effect on the gills and liver of C. gariepinus. The physico-parameters (pH, conductivity, total dissolved solid, salinity, temperature, dissolved oxygen, chemical oxygen demand, biological oxygen demand) and heavy metals (lead, cadmium, chromium, copper and nickel) were also analyzed using standard methods. The results of physico-chemical analyses of leachate showed contamination of organics, salts and heavy metals. Furthermore, lethal concentration (LC50) of leachate effluent on C. gariepinus was determined using probit method to ascertain fish mortality. Result revealed that C. gariepinus exposed to different concentration of raw leachate recorded increasing mortality of 0, 0, 1, 4 and 5 at 0%, 5%, 10%, 25% and 75% concentration respectively for a period of 96 hours. The colour and behavioral responses were normal in the control experiment. But there were abnormal behavior including erratic swimming and quick sudden movements in concentrated samples. Also, results of the histopathological analysis showed alterations in the gills and liver. The study concluded that raw leachate is toxic to C. gariepinus, and therefore recommends for adjusting factors enhancing anaerobic biodegradation that lead to leachate stabilization as well as treatment and monitoring of effluent released into water bodies.
Histopathological, Pathomorphological and Oxidative Stress Responses of Glyphosate Exposed Probiotics Fed Clarias gariepinus
Authors: Ashade O. O. , Mbuonye A. G. , Amaeze N. H. , Amolegbe A. O. , Adedeji R. A. 
Published: November 2023

This study assessed changes in tissues and antioxidant enzymatic activities of glyphosate exposed probiotics fed Clarias gariepinus. Sublethal exposure of 1/10 and 1/100 LC50 at 0.1%, 0.15% and 0.2% probiotics inclusions was carried out for 28days. Histological and oxidative stress biomarkers were determined using standard methods. Histopathological as well as structural changes and antioxidant enzyme activities in studied organs were dose dependent considering the concentration and percentage of glyphosate and probiotics respectively. Exposure at 1/10 and 1/100 LC50 erodes and destroys tissue architecture in proportionate fashion expressed as lamella erosion and necrosis in gills and liver respectively with corresponding reduced SOD, CAT and GSH activities in the liver. Regeneration and healing of tissues were more pronounced at C. gariepinus fed 0.2% probiotics 1/10 LC50 exposure level as against 0.15% probiotics 1/100 LC50 exposure level. Antioxidant enzyme activities increased significantly (p < 0.05) in glyphosate probiotics fed C. gariepinus compared to 0% probiotics fed glyphosate exposed fish. CAT and GSH were higher at 0.2% probiotics compared to control. Level of peroxidation reduced as percentage of probiotics increased with control MDA value the highest compared to those at different inclusion levels. Conclusively, probiotics can help reduce cytotoxic effects of toxicants and stressors in Clarias gariepinus at relative inclusion levels.