bluuebunny/crossref_metadata_2025_split huggingface dataset:
The impact of COVID-19 on pulmonary, neurological, and cardiac outcomes: evidence from a Mendelian randomization study
Authors: Shenoy Pooja U. , Udupa Hrushikesh , KS Jyothika , Babu Sangeetha , K Nikshita , Jain Neha , Das Ranajit , Upadhyai Priyanka 
Published: December 2023

BackgroundLong COVID is a clinical entity characterized by persistent health problems or development of new diseases, without an alternative diagnosis, following SARS-CoV-2 infection that affects a significant proportion of individuals globally. It can manifest with a wide range of symptoms due to dysfunction of multiple organ systems including but not limited to cardiovascular, hematologic, neurological, gastrointestinal, and renal organs, revealed by observational studies. However, a causal association between the genetic predisposition to COVID-19 and many post-infective abnormalities in long COVID remain unclear.MethodsHere we employed Mendelian randomization (MR), a robust genetic epidemiological approach, to investigate the potential causal associations between genetic predisposition to COVID-19 and long COVID symptoms, namely pulmonary (pneumonia and airway infections including bronchitis, emphysema, asthma, and rhinitis), neurological (headache, depression, and Parkinson’s disease), cardiac (heart failure and chest pain) diseases, and chronic fatigue. Using two-sample MR, we leveraged genetic data from a large COVID-19 genome-wide association study and various disorder-specific datasets.ResultsThis analysis revealed that a genetic predisposition to COVID-19 was significantly causally linked to an increased risk of developing pneumonia, airway infections, headache, and heart failure. It also showed a strong positive correlation with chronic fatigue, a frequently observed symptom in long COVID patients. However, our findings on Parkinson’s disease, depression, and chest pain were inconclusive.ConclusionOverall, these findings provide valuable insights into the genetic underpinnings of long COVID and its diverse range of symptoms. Understanding these causal associations may aid in better management and treatment of long COVID patients, thereby alleviating the substantial burden it poses on global health and socioeconomic systems.
Monitoring load, wellness, and psychological variables in female and male youth national team football players during international and domestic playing periods
Authors: Andersen Thomas Rostgaard , Kästner Bennet , Arvig Mathias , Larsen Carsten Hvid , Madsen Esben Elholm 
Published: December 2023

AimTo study differences in total load exposure, wellness, and psychological variables in youth female (N = 19) and male (N = 20) national team football players during domestic and international playing periods, respectively.ProceduresThe players filled out questionnaires on well-being, stress, and resilience before and after both playing periods lasting 8 days each. The Hooper index was used to monitor daily wellness levels during both playing periods. The number of training sessions and matches were recorded, and the session rating of perceived exertion was collected. Training load, monotony, and strain were calculated. Daily measurements were used to evaluate in-period changes, and composite scores were used to describe differences between periods.ResultsThe international compared to the domestic playing period was for both groups characterized by more matches played, longer field training session durations, and of fewer gym-based sessions (P &lt; 0.05). The male players increased total exposure time (25%; P &lt; 0.05), monotony (P &lt; 0.001), and strain (P &lt; 0.001), which was not changed in the female players. Well-being decreased (P &lt; 0.05) during the international playing period in male players. Stress levels were higher (P &lt; 0.05) for both genders during the international compared to the domestic playing period. During the international playing period, positive correlations were found between the initial levels of stress, and the change in stress (P = 0.03; r2 = 0.12), and between the changes in total load and changes in well-being (P = 0.02; r2 = 0.12), whereas a negative correlation was found between the changes in wellness and stress (P = 0.03; r2 = 0.14).ConclusionA playing period characterized by increased match focus, longer field training sessions, and fewer gym-based training activities may lead to changes in the physical and mental profiles of youth national team football players. Alterations to load exposure and wellness may influence mental health. Players with high initial stress levels may be subjected to greater changes compared to other players. Sports scientists and medical staff may benefit from initiating structured monitoring systems to track alterations in physical load and mental health in youth national team players.
Wound healing of experimental equine skin wounds and concurrent microbiota in wound dressings following topical propylene glycol gel treatment
Authors: Labens Raphael , Raidal Sharanne , Borgen-Nielsen Cathrine , Pyecroft Stephen , Pant Sameer D. , De Ridder Thomas 
Published: December 2023

IntroductionTopical wound treatments rely on carrier formulations with little to no biological impact. The potential for a common vehicle, a propylene glycol (PG) gel, to affect wound healing measures including microbiota is not known. Microbiome characterization, based on next generation sequencing methods is typically performed on tissue or directly obtained wound fluid samples. The utility for primary wound dressings to characterize equine wound microbiota in the context of topical treatments is currently unknown. This investigation reports the topical effect of an 80% PG based gel on wound healing and microbiota in wound dressings.MethodsExperiments were performed in six mature horses utilizing a surgical, distal limb wound model, histology of sequential wound biopsies, photographic wound measurements and microbiota profiling via 16s rRNA sequencing of wound dressing samples. Experimental wounds were surveyed for 42 days and either treated (Day 7, 14, 21 and 28; at 0.03 ml/cm2) or unexposed to the PG gel. Wound surface area, relative and absolute microbial abundances, diversity indices and histologic parameters were analyzed in the context of the experimental group (treatment; control) using qualitative or quantitative methods depending on data characteristics.ResultsCompared to controls, treatment slowed the wound healing rate (17.17 ± 4.27 vs. 18.56 ± 6.3 mm2/day), delayed the temporal decline of polymorphonucleated cells in wound beds and operational taxonomic units (OTU) in wound dressings and lowered alpha-diversity indices for microbiota in primary wound dressing. Relative abundances of OTUs were in line with those previously reported for equine wounds. Clinical outcomes 42 days post wounding were considered similar irrespective of PG gel exposure.DiscussionResults highlight the potential for vehicle exposure to alter relevant wound outcome measures, imposing the need for stringent experimental control measures. Primary wound dressings may represent an alternate sample source for characterization of the wound microbiome alleviating the need for additional interventions. Further studies are warranted to contrast the microbiome in wound dressings against that present on wound surfaces to conclude on the validity of this approach.
Patient influence on general practice service improvement decision making: a participatory research mixed-methods intervention study
Authors: Drinkwater Jessica , MacFarlane Anne , Twiddy Maureen , Meads David , Chadwick Ruth H , Donnelly Ailsa , Gleeson Phil , Hayward Nick , Kelly Michael , Mir Robina , Prestwich Graham , Rathfelder Martin , Foy Robbie 
Published: December 2023

Background
Health policy promotes patient participation in decision making about service organisation. In English general practice this happens through contractually required patient participation groups (PPGs). However, there are problems with the enactment of PPGs that have not been systematically addressed.

Aim
To observe how a co-designed theory-informed intervention can increase representational legitimacy and facilitate power sharing to support PPGs to influence decision making about general practice service improvement.

Design and setting

Participatory action research to implement the intervention in two general practices in the North of England was undertaken. The intervention combined two different participatory practices:
partnership working
involving externally facilitated meetings with PPG members and staff; and
consultation
with the wider patient population using a bespoke discrete choice experiment (DCE).

Method
To illustrate decision making in PPGs, qualitative data are presented from participant observation notes and photographed visual data generated through participatory methods. The DCE results are summarised to illustrate how wider population priorities contributed to overall decision making. Observational data were thematically analysed using normalisation process theory with support from a multi-stakeholder co-research group.

Results
In both general practices, patients influenced decision making during PPG meetings and through the DCE, resulting in bespoke patient-centred action plans for service improvement. Power asymmetries were addressed through participatory methods, clarification of PPG roles in decision making, and addressing representational legitimacy through wider survey consultation.

Conclusion
Combining participatory practices and facilitated participatory methods enabled patients to influence decision making about general practice service improvement. The policy of mandatory PPGs needs updating to recognise the need to resource participation in a meaningful way.
Estrategia neurodidáctica: consolidar comprensión del aprendizaje en el despertar cognitivo
Authors: González Sánchez Jaime , Núñez Michuy Carlos , Guaraca Parreño Susana 
Published: December 2023

El propósito de esta investigación se basó en la incorporación de la neuroeducación en el ámbito educativo; el objetivo propuesto fue implementar una estrategia neurodidáctica para fortalecer la comprensión de aprendizaje en estudiantes de una institución educativa de bachillerato en la ciudad de Guayaquil. De carácter experimental, alcance evaluativo, con un diseño cuasiexperimental. Estuvo compuesto por un grupo de control y otro experimental, conformados por 30 discentes cada uno. La técnica para la recolección de los datos fue la encuesta y, el instrumento, un cuestionario con 24 preguntas de análisis diseñadas en relación a las dimensiones de la variable de estudio. Para la comprobación de la hipótesis se aplicó la prueba T de student, los niveles de comprensión alto y bajo, se obtuvieron como resultados 3% y 23% en pretest, 3% y 17% en postest. Se aceptó la hipótesis de investigación en base al resultado inferencial con una t=4,3555 y Sig 0,000 menor que 0,05.
Critical success factors in asset securitisation in banks in India
Authors: Ramachandran Gopalan , Gumparthi Srinivas , Aziz Tariq 
Published: December 2023

Asset securitization is the structured business process whereby Banks’ loan assets and other receivables are packaged and sold in the form of ‘asset-backed securities’(ABS), thereby loan originators transfer some of their loan-risks to third parties. Asset securitization considers a pool of performing/non-performing retail loan assets and through financial engineering models, transforms them to tradable security by involving a Special Purpose Vehicle (SPV) that issues Negotiable Instruments (like Bonds/Promissory Notes/CPs) called Pass Through Certificates (PTCs) to Investors. In Indian context, most asset securitisation deals are done on Direct Assignment (DA) basis through retail loans-asset pool transfer to pool-buyer Bank with no SPV in between and hence no tradable security. This Research study analysed ‘Critical Success Factors (CSFs)’ in Indian model of asset securitisation (Li Liu, 2021) and in the process also analysed its associated business-processes, systematic-risks, Issues & challenges. This study sourced its primary data from hands-on deal-practitioners and Subject Matter Experts (SMEs) associated with deal-participating entities and through qualitative data analysis technique of Narrative analysis and Applied Conversation analysis, the research-findings are concluded. The CSFs include - key business benefits including achieving lending targets & compliance norms, supporting IT systems, immediate liquidity support (Chilukani Munender Reddy, 2018). Towards future prospects and challenges (Lakshman Alles, 2021), this study suggests for setting up ‘Centre of Excellence (CoE) for Assets Securitisation’ in each bank, for ‘building product-expertise and evolve appropriate asset-pricing-models for deals and PTC securities’. The study also suggests for an ‘Enabling IT systems’ that support automated deal-processes, risk-monitoring and compliance tracking’. These two aspects would facilitate for better deal-transparency and for making informed decisions by deal stake-holders.
ANALISIS PENGENDALIAN INTERNAL ATAS PERSEDIAAN BARANG DAGANG
Authors: Suasri Eni , Zuliana Dena 
Published: December 2023

Penelitian ini bertujuan untuk menganalisis penerapan pengendalian internal di Alfamart Kecamatan Pelaihari yaitu Alfamarat Panggung km 06, Alfamart Angsau dan Alfamart KH. Mansur berdasarkan 5 komponen pengendalian internal menurut COSO (2017 yaitu Tata Kelola dan budaya, Strategi dan Penetapan Tujuan, Kinerja, Penelaahan dan revisi, Informasi, Komunikasi dan pelaporan. Analisis pengendalian internal menggunakan data yang didapatkan melalui observasi, wawancara dan studi pustaka Jenis data yang digunakan yaitu data kualitatif dengan metode deskriptif kualitatif. Hasil penelitian menunjukkan bahwa penerapan pengendalian internal atas persediaan barang dagang pada Alfamart Panggung KM. 06 sebesar 100% telah sesuai dengan COSO (2017) hal ini menunjukkan bahwa pengendalian internal atas persediaan barang dagang pada Alfamart Panggung KM.06 termasuk kriteria sangat efektif, hasil penelitian Alfamart Angsau untuk penerapan pengendalian internal atas persediaan barang dagang sebesar 59,37% telah sesuai dengan COSO (2017) hal ini menunjukkan bahwa pengendalian internal atas persediaan barang dagang termasuk kategori kurang efektif. Hasil penelitian Alfamart KH. Mansur untuk penerapan pengendalian internal atas persediaan barang dagang sebesar 90,62% telah sesuai dengan COSO (2017), hal ini menunjukkan bahwa pengendalian internal atas persediaan barang dagang termasuk kategori sangat efektif.
Charg – Strauss Syndrome or Eosinophilic Granulomatosis with Polyangiitis in Combination with Comorbid Pathology (Clinical Case)
Authors: Левянкова А.Л. , Будрицкий А.М. , Михневич Д.В. , Волков А.В. 
Published: December 2023

Синдром Чарга – Стросса, или эозинофильный гранулематоз с полиангиитом (ЭГПА), впервые описан Дж. Чаргом (Jacob Churg) и Л. Строссом (Lotte Strauss) в 1951 году. ЭГПА представляет собой системный некротизирующий васкулит малых и сред- них сосудов с развитием экстраваскулярных гранулем (обычно с большим количе- ством эозинофилов), эозинофилии и эозинофильной инфильтрации тканей. Воз- никает при астме, начавшейся у взрослых, у пациентов с аллергическим ринитом, назальным полипозом или их сочетанием. Согласно рекомендациям, принятым в 2012 году на консенсусной конференции в Чапел Хилл, ЭГПА определяется как эозинофильный воспалительный некротический гранулематоз с вовлечением дыха- тельных путей и некротическим васкулитом мелких и средних сосудов в сочетании с астмой и эозинофилией.
Jacob Churg and Lotte Strauss first described Churg-Strauss syndrome or eosinophilic granulomatosis with polyangiitis (EGPA) in 1951. EGPA is a systemic necrotizing vasculitis of small and medium vessels with the development of extravascular granulomas (usually with a large number of eosinophils), eosinophilia and eosinophilic tissue infiltration. It occurs in asthma that began in adults, in patients with allergic renitis, nasal polyposis or a combination of both. According to the recommendations adopted in 2012 at the Chapel Hill consensus conference, EGPA is defined as eosinophilic inflammatory necrotizing granulomatosis with respiratory involvement and necrotizing vasculitis of small and medium vessels in combination with asthma and eosinophilia.
Tingkat Keberhasilan Pemberian Pupuk Super Nasa Dan Power Nutrition Nasa Terhadap Pertumbuhan Dan Produksi Terung (Solanum melongena L)
Authors: Napa Demma , Nurdin Dahlia , M S Satriani 
Published: December 2023

Penelitian ini dilaksanakan di Kecamatan Mamasa Kabupaten Mamasa Provinsi Sulawesi Barat, yang dilaksanakan bulan April sampai dengan Juni 2022, bertujuan untuk mengetahui keberhasilan pemberian pupuk super nasa dan power nutrition terhadap pertumbuhan, produksi tanaman Terung. Metode penelitian menggunakan Rancangan Acak Kelompok terdiri dari enam perlakuan yaitu: N0 = tanpa pemberian, N1 = pupuk super nasa 7,5gr / 15lt air / perlakuan, N2 = pupuk power nutrition nasa 7,5gr / 15lt air / perlakuan, N3 = pupuk super nasa 15gr + pupuk power nutrition nasa 7,5gr / 15lt air / perlakuan, N4 = pupuk super nasa 7,5gr + pupuk power nutrition nasa 15gr / 15lt air / perlakuan, dan N5 = pupuk super nasa 15gr + pupuk power nutrition nasa 15gr / 15lt air / perlakuan. Setiap perlakuan diulang 3 kali sehingga terdapat 15 unit penelitian. Hasil penelitian menunjukkan bahwa pemberian pupuk super nasa dosis 15gr + pupuk power nutrition nasa dosis 15gr dilarutkan dalam 15lt air perlakuan-1 (N5) berpengaruh baik pada tinggi tanaman umur 42 hari setelah tanam, jumlah daun umur 28, 42, dan 49 hari setelah tanam, dan jumlah buah pada tanaman Terung.
Penguatan Kelembagaan Pada Organisasi Pengelola Zakat Melalui Good Amil Governance (GAG)
Authors: Fatmawati Fatmawati , Iswandi Heri , Fauziah Fauziah , Herviani Septy 
Published: December 2023

Penelitian ini bertujuan untuk mengkaji Penguatan Kelembagaan pada Organisasi Pengelola Zakat (OPZ) melalui Good Governance. Masalah yang masih terkait dengan pengelolaan zakat, salah satunya yaitu masalah yang bersumber dari dalam Lembaga Pengelola Zakat Itu sendiri antara lain menjamurnya jumlah Lembaga Amil Zakat (LAZ), rendahnya sinergi antara stakeholder, rendahnya kredibilitas masyarakat terhadap OPZ, tidak optimalnya pendayagunaan zakat serta SDM zakat yang masih kurang profesional. Oleh karena itu dibutuhkan sebuah model yang dapat mengatasi masalah tersebut. Tata kelola yang baik atau good governance mutlak dibutuhkan dalam Organisasi Pengelola Zakat (OPZ). Penelitian ini merupakan penelitian library research dengan menggunakan analisis kualitatif deskriptif. Hasil penelitian menunjukkan bahwa penguatan kelembagaan dalam OPZ melalui penerapan good amil governance meliputi, pertama sebagai lembaga keuangan publik, maka harus menerapkan prinsip transparency, accountability, responsibility, independency dan fairness. Kedua, sebagai Lembaga Filantropi Islam mutlak menerapkan shariah compliance. Ketiga, sebagai lembaga pelayanan masyarakat harus mengedepankan service quality.
Persaingan Usaha Dalam Perspektif Etika Bisnis Islam (Studi Kasus Pedagang Ayam Geprek di Kelurahan Sidodadi)
Authors: Malik Abdul , Busrah Busrah , Hidayah Jasmiah Nur 
Published: December 2023

Tujuan penelitian ini adalah: 1) untuk mengetahui bagaiamana persaingan usaha pedagang ayam geprek di Kelurahan Sidodadi 2) untuk mengetahui bagaimana perspektif etika bisnis Islam terhadap persaingan usaha pedagang ayam geprek di Kelurahan Sidodadi. Jenis penelitian ini menggunakan jenis penelitian kualitatif, yang mana penelitian kualitatif bertujuan untuk mendeskripsikan dan menganalisis fenomena, peristiwa. Hasil penelitian ini menunjukkan bahwa persaingan usaha yang terjadi di Kelurahan Sidodadi antara pedagang ayam geprek tersebut, cukup ketat tetapi mereka bersaing secara sehat. Untuk memenangkan persaingan yaitu mengutamakan rasa, memberikan pelayanan yang terbaik, serta mempromosikan melalui media sosial dan ada juga yang secara langsung. Pedagang ayam geprek di kelurahan Sidodadi percaya bahwa rezeki sudah ada yang mengaturnya. Kemudian dalam perspektif etika bisnis Islam, para pedagang ayam geprek di Kelurahan Sidodadi menerapkan 4 prinsip etika bisnis Islam yaitu: mereka percaya bahwa rezeki sudah ada yang mengatur, ini sesuai dengan prinsip tauhid, tidak melakukan banting harga, ini sesui dengan prinsip keseimbangan (adil), tidak memaksa pelanggan untuk membeli ayam gepreknya, ini sesuai dengan prinsip kehendak bebas, memberikan pelayanan yang terbaik kepada konsumen, ini sesuai dengan prinsip kebenaran (kebijakan).
Strategi Komisi Pemilihan Umum (KPU) Kabupaten Polewali Mandar Dalam Menekan Angka Golput Pada Pemilihan Presiden Tahun 2019 (Studi Kasus Kecamatan Campalagian)
Authors: Saleh Ahmad , Fitrah Nur , Febriani Wilda 
Published: December 2023

Penelitian ini bertujuan untuk mendeskripsikan dan mengetahui bagaimana Stratetegi KPU Kabupaten Polewali Mandar dalam menekan angka golput pada pemilihan presiden tahun 2019 yang berfokus di kecamatan campalagian. Pengumpulan data dilakukan dengan taknik wawancara, observasi dan pengamatan langsung. Kemudian menggunakan metode penelitian kualitatif. Teori yang digunakan dalam penelitian ini adalah teori strategi komunikasi. Berdasarkan hasil penelitian ini menunjukkan bahwa pada pemilihan umum presiden tahun 2019 Strategi KPU Kabupaten Polewali Mandar dalam menekan angka golput di Kecamatan Campalagian yaitu menggunkan 4 (empat) indikator strategi. 1 ) Strategi Penguatan yang dilakukan KPU Kabupaten Polewali Mandar sudah profesional dan berintegritas lewat perencanaan program, melakukan pendataan daftar pemilih tetap, melakukan sosialisasi dan rapat kerja. 2) Stratgi Rasionalisasi yang dilakukan KPU Kabupaten Polewali Mandar yaitu memberikan informasi selebaran kertas berisi gambar calon pasangan melalui sosial media dan pemasangan baliho. 3) Strategi bujukan yang dilakukan KPU Kabupaten Polewali Mandar yaitu melakukan sosialisasi melalui kegiatan-kegiatan seni dan kegiatan jalan santai agar menarik pemilih untuk meningkatkan partisipasinya, dan 4) Strategi Konfrontasi yang dilakukan oleh KPU Kabupaten Polewali Mandar yaitu membentuk relawan demokrasi untuk melakukan sosialisasi khusus pada kelompok perempuan, kelompok keagamaan, kelompok pemilih pemula, kelompok marginal, dan kelompok penyandang disabilitas yang sudah dijelaskan di bab pembahasan.
Karakteristik Komunikasi Interpersonal Orang Tua Terhadap Anak Dalam Meningkatkan Minat Belajar
Authors: Yuyun Sri , Gay Munawi , Hasmiah Hasmiah 
Published: December 2023

karakteristik komunikasi interpersonal orang tua terhadap anak dalam meningkatkan minat belajar. Penelitian ini menggunakan pendekatan kualitatif yang bersifat deskriptif, selanjutnya data yang diperoleh berasal dari hasil observasi dilapangan dengan sistem wawancara, dokumentasi dengan para orang tua. Hasil penelitian menunjukan bahwa orang tua sangat minim berkomunikasi secara interpersonal kepada anak. Anak dengan intensitas komunikasi yang tinggi dengan orang tua akan berbeda dengan anak yang cenderung menutup diri dengan orang tua, termasuk bagaimana anak menerima perintah untuk giat dalam belajar. Orang tua harus pandai memainkan peran tidak hanya memenuhi kebutuhan anak secara eksternal tapi juga kebutuhan anak secara internal seperti kebutuhan untuk didengarkan, kebutuhan pendekatan secara emosional dan kebutuhan kesehatan mental lainnya. Kesimpulan bahwa komunikasi interpersonal orang tua terhadap anak dalam meningkatkan minat belajar di Desa Mammi, menunjukan beragam pola dan tipe interaksi dalam meningkatkan minat belajar