bluuebunny/crossref_metadata_2025_split huggingface dataset:
Eficacia del Ultrasonido Endoscópico en Cirugía General: impacto y resultados
Authors: Chicaiza Quishpe Andrea Alejandra , Leiva Suero Lizette Elena , Chicaiza Tayupanta Jesús Onorato , Quishpe Jara Graciela de las Mercedes 
Published: January 2025

El ultrasonido endoscópico es una herramienta diagnóstica avanzada en Cirugía General que surge de la combinación (endoscopia + ultrasonido) y ofrece una evaluación detallada de órganos internos y estructuras vecinas. El objetivo del estudio fue desarrollar una revisión sistemática de la literatura médica existente sobre la eficacia del ultrasonido endoscópico en Cirugía General durante el periodo 2019-2024. Se realizó un metaanálisis basado en la metodología Prisma, que incluyó una revisión sistemática de la literatura científica publicada en bases de datos de cobertura mundial: Scopus, Proquest y Web of Science en los últimos cinco años (2019-2024) en idioma español o inglés, a partir de los descriptores específicos en ambos idiomas, para sobre la eficacia del ultrasonido endoscópico en Cirugía General. Dos de los autores de esta investigación revisaron de forma independiente la literatura, mientras que un revisor extractó los datos. Se emplearon dos modelos para combinar estadísticamente los resultados, el modelo de efectos fijos y el modelo de efectos aleatorios, lo cual permitió resumir de manera sintética los aportes e impacto del ultrasonido endoscópico. Quedaron incluidos 42 estudios: 23 Series de Casos, 6 Ensayos Clínicos, 6 Cohortes, 1 Casos y Controles, 1 Estudio explicativo experimental y 7 Metaanálisis. Se demostró la eficacia del ultrasonido endoscópico para diagnosticar, estadificar y tratar diversas patologías quirúrgicas; su capacidad para visualizar en detalle las estructuras internas del tracto gastrointestinal, el páncreas y las vías biliares que permitió una evaluación precisa de tumores y lesiones submucosas, así como la realización de biopsias con mínima invasión; por otro lado, facilitó intervenciones terapéuticas como el drenaje de abscesos o pseudocistes y la colocación de stents, lo que reduce la necesidad de cirugías invasivas en pacientes con lesiones estenóticas. Se puede concluir que estas características lo convierten en una herramienta indispensable que incide en el diagnóstico precoz y el tratamiento oportuno en patologías quirúrgicas, mejorando significativamente el pronóstico, particularmente en oncología.
The Fall of the Cosmic Mind: Cosmopsychism, the Satan Hypothesis, and Natural Evil
Authors: Cawdron Harvey 
Published: January 2025

[Figure: see text] Christian philosophers often use moral agents to explain the existence of evil. The fall of human beings can be used in explanations of moral evil, and some have posited the existence of angels to explain natural evil. The latter proposal, which has been labelled “the Satan hypothesis,” has faced substantial criticism. Here, I do not dismiss the Satan hypothesis, but present cosmopsychism, the idea that the universe is conscious, as an alternative way of using moral agents to explain natural evil for those skeptical of the Satan hypothesis. After introducing cosmopsychism into this debate and outlining how it can be used instead of the Satan hypothesis, I consider how it can provide an explanation of natural evil.
The Politics of the “New Evangelization” in the Post-Conciliar Catholic Church
Authors: Olkovich Nicholas 
Published: January 2025

[Figure: see text] Following rhetorical theorist Michael McGee, Benjamin Bennett-Carpenter and Michael J. McCallion contend that the term “new evangelization” may be understood as an “ideograph,” a symbolic reference point that galvanizes Catholics with different ideological sensibilities. This paper explores the “political” struggle to fix the meaning of this ideograph after the Second Vatican Council by distinguishing between two broad trends. The roots of the new evangelization as a nodal point in the post-conciliar era lie in the Latin American church's appropriation of Vatican II, beginning with the Conference of Latin American Bishops’ meeting at Medellin in 1968. This first strand of interpretation views justice as a constitutive dimension of the church's mission and tends to view evangelization in light of “liberation.” As articulated by Pope John Paul II, a second more mainstream or official strand views evangelization in principally spiritual terms and focuses on developing “new methods” for communicating doctrine and on fostering personal conversion to Christ within the secularized West. This approach tends to emphasize humankind's vertical relationship to God—as well as the uniqueness of Christ—and to view the poor as recipients of charitable work rather than as agents of transformation. Although Pope Francis’ program of ecclesial reform seeks to retrieve elements of the first strand, some proponents of the second strand have responded by rejecting Francis outright or by sanitizing his vision for their own purposes.
Looking and Listening for Lived Theologies of Truth and Reconciliation: Learning from a Diffuse Art Installation in the Anglican Diocese of Ottawa
Authors: Johnson Sarah Kathleen 
Published: January 2025

[Figure: see text] Christian complicity in colonialism and the need for truth telling and reconciliation with Indigenous peoples have been a central focus of academic theological research shared at the Canadian Theological Society in recent years. Many Canadian churches have offered official apologies and made formal commitments to right relations with Indigenous peoples. This paper considers the experience of “people in the pews.” Taking a diffuse visual art installation of white ceramic feathers as a starting point, it traces the contours of how local congregations in the Anglican Diocese of Ottawa are engaged with truth and reconciliation intellectually, emotionally, and actively. It names the need to bridge the gaps between academic theology and lived theology, and official church statements and everyday practices in congregations. It invites academic theologians to consider the questions: To whom are we listening? Who is listening to us?
Unified Guidance for Geometry-Conditioned Molecular Generation
Authors: Ayadi Sirine , Hetzel Leon , Sommer Johanna , Theis Fabian , Günnemann Stephan 
Published: January 2025

Effectively designing molecular geometries is essential to advancing pharmaceutical innovations, a domain, which has experienced great attention through the success of generative models and, in particular, diffusion models. However, current molecular diffusion models are tailored towards a specific downstream task and lack adaptability. We introduce UniGuide, a framework for controlled geometric guidance of unconditional diffusion models that allows flexible conditioning during inference without the requirement of extra training or networks. We show how applications such as structure-based, fragment-based, and ligand-based drug design are formulated in the UniGuide framework and demonstrate on-par or superior performance compared to specialised models. Offering a more versatile approach, UniGuide has the potential to streamline the development of molecular generative models, allowing them to be readily used in diverse application scenarios.
Exploring QGP-Like Phenomena with Charmonia in p+p Collisions at √s=13 TeV
Authors: Singh Captain R. , Bagchi Partha , Sahoo Raghunath , Alam Jan-e 
Published: January 2025

In ultra-relativistic collisions of nuclei at the Large Hadron Collider, the created QCD environment rapidly changes, leading to a non-adiabatic evolution of the quantum states involved. Considering this, we first examine the pre-equilibrium state of QCD matter and its effect on the initially produced charmonium using a temperature-independent Hamiltonian. As the QCD matter reaches local thermal equilibrium, this Hamiltonian transforms to its finite temperature counterpart. To model the pre-equilibrium stage, we use the bottom-up thermalization approach to determine the effective temperature of the QCD matter, followed by a Gubser-type expansion for the thermalized medium. Additionally, we consider collisional damping, gluonic dissociation, and regeneration mechanisms, which specifically modify the charmonium yield in the thermalized medium. Mainly, the gluonic dissociation and collisional damping cause a reduction in the yield conversely, regeneration through gluonic de-excitation enhances the yield of charmonium. Further, we explore the combined effects of these mechanisms on the collective yield of charmonium states with transverse momentum (\(p_T\)) and event multiplicity in the proton-proton collisions at \(\sqrt{s}=13\) TeV. Based on our findings, we contend that the combined effects of these mechanisms can serve as a robust probe for determining the possible existence of a thermalized QCD medium in such a small collision system.
Compositional Data Analysis for Modelling and Forecasting Mortality with the α-Transformation
Authors: Lim Han Ying , Pathmanathan Dharini , Dabo-Niang Sophie 
Published: January 2025

Mortality forecasting is crucial for demographic planning and actuarial studies, particularly for predicting population ageing rates and future longevity risks. Traditional approaches largely rely on extrapolative methods, such as the Lee-Carter model and its variants which use mortality rates as inputs. In recent years, compositional data analysis (CoDA), which adheres to summability and non-negativity constraints, has gained increasing attention from researchers for its application in mortality forecasting. This study explores the use of the \(\alpha\)-transformation as an alternative to the commonly applied centered log-ratio (CLR) transformation for converting compositional data from the Aitchison simplex to unconstrained real space. The \(\alpha\)-transformation offers greater flexibility through the inclusion of the \(\alpha\)parameter, enabling better adaptation to the underlying data structure and handling of zero values, which are the limitations inherent to the CLR transformation. Using age-specific life table death counts for males and females in 31 selected European countries/regions from 1983 to 2018, the proposed method demonstrates comparable performance to the CLR transformation in most countries with improved forecast accuracy in some cases. These findings highlight the potential of the \(\alpha\)-transformation as a competitive alternative transformation technique for real-world mortality data within a non-functional CoDA framework.
More Than Numbers: The Relationship Between Belonging and Engagement in an Introductory Statistics Course
Authors: Pressimone Beckowski Catherine , Torsney Benjamin M. 
Published: January 2025

More college students from diverse backgrounds and disciplines are enrolling in introductory statistics courses. In these courses, active learning, collaborative projects, and relatable content can help to support student learning, belonging, and engagement. In this study, we examined the effect of student-perceived peer, faculty, and classroom belonging on three dimensions of student engagement in a music-themed introductory statistics course. We identified significant models for each dimension of engagement: absorption (conditional R2 = .76, marginal R2 = .26), dedication (conditional R2 = .81, marginal R2 = .28), and vigor (conditional R2 = .79, marginal R2 = .25). We found significant associations between (a) classroom belonging and dedication, vigor, and absorption, and (b) faculty belonging and absorption. The absorption model demonstrated a significant interaction, with students’ sense of faculty belonging declining over time. Qualitatively, students perceived the course theme, instructors, and peer collaboration as supportive. Implications suggest that instructors can take creative, high-impact approaches to teaching introductory statistics. Fostering students’ engagement and belonging may help to offset students’ anxiety or disinterest and help them to become more autonomous learners.
PEMBERIAN PAKAN BERBASIS MAGOT DAN LIMBAH SAWI TERHADAP PERTUMBUHAN IKAN NILA (Oreochromis niloticus)
Authors: Oktamalia Oktamalia , Hamron Novita , Sari Dia Novita , Togatorop Eny Rolenti 
Published: January 2025

Tepung ikan menjadi bahan baku pakan yang paling utama digunakan karena mengandung protein tinggi. Saat ini pemenuhan tepung ikan masih dipasok dari luar negri. Indonesia mengimpor 121 ribu ton tepung ikan tahun 2023. Hal ini berdampak pada harga pakan yang mahal. Selain itu, tepung ikan diproduksi dari hasil penangkapan ikan di laut yang mengancam keberlanjutan populasi ikan. Tepung magot dan tepung limbah sawi sebagai sumberdaya lokal dapat menjadi solusi dalam pemenuhan sumber protein alternatif sebagai bahan pakan ikan secara berkelanjutan. Penelitian bertujuan untuk mengevaluasi respon pertumbuhan ikan nila terhadap pengaruh penambahan bahan pakan ikan dari tepung magot dan tepung limbah sawi. Penelitian menggunakan Rancangan Acak Lengkap (RAL) faktor tunggal dengan empat perlakuan yaitu: P1: tepung ikan 75% + tepung magot 12,5% +12,5% tepung limbah sawi, P2: tepung ikan 50% + tepung magot 25% + tepung limbah sawi 25%, P3: tepung ikan 25% + tepung magot 37,5% + tepung limbah sawi 37,5%, P4: tepung ikan 0% + tepung magot 50% + tepung limbah sawi 50%. Hasil penelitian menunjukkan bahwa pemberian pakan buatan berbasis magot dan limbah sawi perlakuan P4 (tepung ikan 0% + tepung magot 50% + tepung limbah sawi 50%) memberikan performa pertumbuhan ikan nila terbaik dengan laju pertumbuhan harian sebesar 2,13%, panjang mutlak 2,61 cm, bobot mutlak 5,19 g, persentase peningkatan panjang 32,49 % dan kelangsungan hidup 100%.
Efficacy and Flavonoid Levels in Sorghum Extracts of Super 2 Variety Under Various Levels of Drought Stress
Authors: Susilo Edi , Pujiwati Hesti 
Published: January 2025

Bioherbisida berbasis alelopati tanaman sorgum yang tercekam kekeringan merupakan suatu langkah konkrit pertanian berkelanjutan. Tujuan penelitian ini untuk melihat karakteristik perkecambahan benih dan kadar flavonoid dari ekstrak yang telah mengalami berbagai tingkat cekaman kekeringan. Bahan ekstrak disiapkan pada bulan Juni hingga Agustus 2024 di Rumah Kaca Universitas Bengkulu, Kandang Limun, Kota Bengkulu, dan uji bioassay dilakukan pada bulan Agustus 2024 di Pematang Gubernur, Muara Bangkahulu, Kota Bengkulu. Analisis flavonoid dilakukan di Laboratorium Penelitian dan Pengujian Terpadu (LPPT) Universitas Gadjah Mada pada bulan Agustus 2024. Penelitian ini menggunakan Rancangan Acak Lengkap (RAL) dengan satu faktor. Satu varietas sorgum yaitu Super 2 ditanam dengan perlakuan cekaman air melalui pola penyiraman setiap hari, 2 hari sekali, 3 hari sekali, 4 hari sekali, dan 5 hari sekali. Unit percobaan berupa cawan petri, dan percobaan diulang sebanyak empat kali. Metode bioassay cawan petri diterapkan dalam percobaan ini. Setiap cawan petri diberi 10 mL ekstrak air, dan 25 biji kacang hijau ditanam dan diinkubasi selama tiga hari. Hasil penelitian menunjukkan bahwa Kadar flavonoid tertinggi dicapai penyiraman setiap 5 hari sekali (3625,00 µg/g) dan terendah oleh penyiraman setiap hari (3165,26 µg/g). Penghambatan kecambah terjadi akibat ekstrak air sorgum yang telah mengalami perlakuan pola penyiraman.
Analisis Kemampuan Literasi Sains dan Berpikir Kritis Siswa SMP pada Pembelajaran IPA
Authors: CAHYANI DWI KURNIA , Nugroho Ary Susatyo , Nizaruddin  , Hayat Muhammad Syaipul 
Published: January 2025

Kemampuan literasi sains dan berpikir kritis siswa sangat penting untuk memenuhi tantangan abad ke-21 terutama pada pembelajaran IPA. Penelitian ini bertujuan untuk mengetahui kemampuan literasi sains dan berpikir kritis siswa SMP. Penelitian ini menggunakan metode deskriptif kuantitatif. Teknik pengumpulan data dengan instrumen soal tes kemampuan literasi sains dan berpikir kritis siswa. Subjek penelitian adalah 29 siswa kelas VIII. Hasil penelitian menunjukkan bahwa kemampuan literasi sains siswa mendapat rata-rata nilai (29,89) sangat kurang. Dari tiga indikator literasi sains berdasarkan PISA, pada mengevaluasi dan mendesain penelitian ilmiah mendapat nilai (41,38) kurang, menafsirkan data dan bukti ilmiah mendapat nilai (20,69) sangat kurang dan menjelaskan fenomena secara ilmiah (27,59) sangat kurang. Sedangkan kemampuan berpikir kritis mendapat mendapat rata-rata nilai (37,93) sangat kurang. Dari lima indikator berpikir kritis berdasarkan kerangka Ennis, memberi penjelasan secara sederhana mendapat nilai (79,31) baik, membangun klasifikasi dasar mendapat nilai (24,14) sangat kurang, membuat inferensi mendapat nilai (31,03) sangat kurang, membuat penjelasan lebih lanjut mendapat nilai (13,79) sangat kurang, mengatur stategi dan taktik mendapat nilai (37,93) sangat kurang, Hasil penelitian tersebut menunjukkan bahwa kemampuan literasi sains dan berpikir kritis siswa SMP pada pembelajaran IPA masih rendah.
3D bioprinting for the production of a perfusable vascularized model of a cancer niche
Authors: Maggiotto Federico , Bova Lorenzo , Micheli Sara , Pozzer Camilla , Fusco Pina , Sgarbossa Paolo , Billi Fabrizio , Cimetta Elisa 
Published: January 2025

The ever-growing need for improved in vitro models of human tissues to study both healthy and diseased states is advancing the use of techniques such as 3D Bioprinting. We here present our results on the development of a vascularized and perfusable 3D tumor mimic for studies of the early steps of Neuroblastoma metastatic spread. We used a multi-material and sacrificial bioprinting approach to fabricate vascularized 3D cell-laden structures and developed a customized perfusion system enabling maintenance of growth and viability of the constructs for up to 3 weeks. Cell phenotypes and densities in co-culture for both the bulk of the construct and the endothelialization of the vascular channels were optimized to better replicate in vivo conditions and ideally simulate tumor progression. We proved the formation of an endothelium layer lining the vascular channel after 14 days of perfused culture. Cells in the bulk of the construct reflected Neuroblastoma growth and its tendency to recruit endothelial cells contributing to neovascularization. We also collected preliminary evidence of Neuroblastoma cells migration towards the vascular compartment, recapitulating the first stages of metastatic dissemination.
The influence of HIV infection on myocardial fibrosis diagnosed by cardiac magnetic resonance imaging in adults: a systematic review and meta-analysis of observation studies
Authors: Mutengo Katongo Hope , Lima Bruno Bezerra , Mutale Wilbroad , Mweemba Aggrey , Kabwe Lorrita , Banda Clive , Kaayunga Callistus , Mulenga Mutale , Heimburger Douglas , Masenga Sepiso K. , Carr John Jeffrey , Kirabo Annet 
Published: January 2025

IntroductionHuman immunodeficiency virus (HIV) infection is linked to myocardial fibrosis. Observational studies using cardiac magnetic resonance (CMR) have explored this relationship but scarcity of data synthesis limits our understanding. Our systematic review and meta-analysis aimed to synthesize associations between HIV and myocardial fibrosis from CMR-based observational studies in adults.MethodsWe identified 12 studies (2013–2024) with 1,769 participants [1,117 people with HIV (PWH)]. Three studies were cohort and nine were cross-sectional. Meta-analysis included seven studies on late gadolinium enhancement (LGE) (1,081 participants: 669 PWH), eight on native T1 mapping (840 participants: 467 PWH), and ten on ECVF (1,603 participants: 992 PWH). We examined myocardial fibrosis prevalence via the prevalence difference in LGE, and severity by mean differences in native T1 mapping values [milliseconds (ms)] and global extracellular volume fraction (ECVF,%) between PWH and HIV-uninfected individuals, using random effects model.Results and discussionPooled analyses showed PWH had a 33% higher prevalence of LGE (95% CI: 12.0%–54.0%, I2 = 94.5%, p &lt; 0.001), a mean native T1 mapping difference of 27.30 ms (95% CI: 11.21–43.39 ms, I2 = 88.2%, p &lt; 0.001), and a mean ECVF difference of 1.85% (95% CI: 0.63%–3.08%, I2 = 90.5%, p &lt; 0.001), respectively. Meta-regression showed no significant associations between ECVF and demographic, HIV-related, or cardiac factors. LGE and native T1 mapping analyses lacked sufficient data for meta-regression. In conclusion, PWH exhibit significantly higher prevalence and severity of myocardial fibrosis compared to HIV-uninfected individuals. But standardized methodologies and further research are essential to enhance consistency.Systematic Review Registrationhttps://www.crd.york.ac.uk/prospero/display_record.php?RecordID=533379, CRD [42024533379].
Overcoming or overstepping? Boundary infrastructure for learning in the context of continuous improvement research-practice partnership
Authors: Bohannon Angel X. , Farrell Caitlin C. , Cook Spencer 
Published: January 2025

IntroductionUnder federal policy guidelines, school districts are increasingly expected to engage with research evidence to guide their efforts around instructional improvement. This article explores how a continuous improvement research-practice partnership (CI RPP) can create opportunities for educators to learn new research-based ideas and practices.MethodsWe present a year long case study of two rural school districts engaged in a CI RPP focused on math instruction.ResultsWe focus show how research-based mathematics ideas introduced by research partners were taken up by teachers, school leaders, instructional coaches, and district leaders. Then we describe how the county office of education created important opportunities for learning through a boundary infrastructure: the network of people, practices, and objects that supported the movement of ideas between research, practice, and CI communities.DiscussionWe highlight the possibilities of county offices as critical actors in CI efforts. We also highlight how the county office’s efforts to broker knowledge did not involve just overcoming or transcending boundaries but also maintaining them when they perceived external partners to be “overstepping.”