bluuebunny/crossref_metadata_2025_split huggingface dataset:
Exploration of potential targets and mechanisms of naringenin in the treatment of nonalcoholic fatty liver disease through network pharmacology
Authors: Yu Chenyang , Han Duan , Yu Jingfang , Zhu Ran , Zhu Cuiyan , Wang Fule , Zhang Tiefeng 
Published: October 2023

Objective:
This study aimed to use network pharmacology to investigate the molecular mechanisms and potential targets of naringenin (NR) for nonalcoholic fatty liver disease (NAFLD) treatment to offer new drug development ideas.

Methods:
The structure and compound information of NR were obtained from PubChem and the traditional Chinese medicine system pharmacology database and analysis platform. The traditional Chinese medicine system pharmacology database and analysis platform Database, Comparative Toxicogenomics Database and Encyclopedia of Traditional Chinese Medicine Database were then used to predict the related targets of NR. Online mendelian inheritance in man, Disgenet, Gene cards, The therapeutic target database and Drug bank were used to screen NAFLD targets, and the intersection analysis was performed with the targets of NR active components to obtain the targets of NR in the treatment of NAFLD. The protein-protein interaction network of therapeutic targets was constructed by protein-protein interaction networks functional enrichment analysis 11.0, and gene ontology (GO) functional enrichment analysis and Kyoto encyclopedia of genes and genomes pathway enrichment analysis of therapeutic targets was performed by Metascape platform.

Results:
In this study, 171 NR targets and 1748 potential targets of NAFLD were screened, and 89 crossover targets and 16 core targets were screened and finally obtained. A total of 176 GO items were obtained by GO enrichment analysis (P < .05), including 389 biological process, 6 cell composition and 30 molecular function. A total of 137 signaling pathways were obtained by Kyoto encyclopedia of genes and genomes pathway enrichment and screening (P < .05). The core targets of NR in the treatment of NAFLD are TP53, CASP3, PRKCA, AKT1, RELA, PPARG, NCOA2, CYP1A1, ESR1, MAPK3, STAT3, JAK1, MAPK1, TNF, PPARA and PRKCB. Enrichment analysis showed that NR mainly involved in biological processes such as cellular response to nitrogen compound, regulation of miRNA transcription and negative regulation of miRNA-mediated gene silencing. It regulates Hepatitis B, Lipid and atherosclerosis, cytomegalovirus infection, Hepatitis C, AGE-RAGE signaling pathway in diabetic patients complications and other ways play a role in the treatment of NAFLD.

Conclusions:
The therapeutic effect of NR on NAFLD has the characteristics of multi-targets and multi-pathways, which provides a preliminary theoretical basis for clinical trials and the development of new drugs.
General anesthesia versus combined interscalene nerve/superficial cervical plexus block in arthroscopic rotator cuff repair: A randomized prospective control trial
Authors: Kilbasanli Seval , Kaçmaz Mustafa 
Published: October 2023

Background:
In this study, interscalene brachial plexus block (ISB) with superficial cervical plexus block added and general anesthesia (GA) application were evaluated in terms of intraoperative hemodynamics, operative time and postoperative analgesia need in patients who underwent rotator cuff tear repair.

Methods:
70 patients aged between 18 and 75 years were included in this prospective study. Arthroscopic rotator cuff tear repair surgery was performed in all patients. The patients were randomized into 2 groups, namely Group ISB who received a combination of superficial cervical plexus block added to the Interscalene Nerve Block, and Group GA, for those who received GA. Duration of operation, waiting times, intraoperative hemodynamic data, postoperative visual analog scale (VAS), analgesic requirement, as well as patient and surgeon satisfaction levels, were compared between the 2 groups.

Results:
While VAS values at the post-anesthesia care unit were lower in ISB group at 2 and 24 hours (P < .05), there was no significant difference between VAS values measured at 6th and 12th hours (P ≥ .05). In the GA group, postoperative morphine and diclofenac consumption was higher, and rescue analgesia was needed earlier (P < .05). The hospital stay was shorter (P < .05), and surgeon and patient satisfaction were higher in the ISB group (P < .05).

Conclusion subsections:
In rotator cuff tear repair anesthesia, ISB with superficial cervical plexus block provides adequate intraoperative anesthesia, low postoperative VAS level, reduced and deferred consumption of opioids and nonsteroidal anti-inflammatory drugs, higher patient and surgeon satisfaction and early discharge.
Differences in productivity and collaboration patterns on spine-related research between neurosurgeons and orthopedic spine surgeons: Bibliometric analysis
Authors: Hsiung Chun , Chou Willy , Chien Tsair-Wei , Chou Po-Hsin 
Published: October 2023

Background:
Spinal surgeries are commonly performed by neurosurgeons and orthopedic spine surgeons, with many spine-related articles published by them. However, there has been limited research that directly compares their research achievements. This article conducted a comparative analysis of spine-related research achievements between neurosurgeons and orthopedic spine surgeons. This study examines differences in productivity and impact on spine-related research between them using these measures, particularly with a novel clustering algorithm.

Methods:
We gathered 2148 articles written by neurosurgeons and orthopedic spine surgeons from the Web of Science core collections, covering the period from 2013 to 2022. To analyze author collaborations, we employed the follower-leader clustering algorithm (FLCA) and conducted cluster analysis. A 3-part analysis was carried out: cluster analysis of author collaborations; mean citation analysis; and a category, journal, authorship, L-index (CJAL) score based on article category, journal impact factors, authorships, and L-indices. We then utilized R to create visual displays of our findings, including circle bar charts, heatmaps with dendrograms, 4-quadrant radar plots, and forest plots. The mean citations and CJAL scores were compared between neurosurgeons and orthopedic spine surgeons.

Results:
When considering first and corresponding authors, orthopedics authors wrote a greater proportion of the articles in the article collections, accounting for 75% (1600 out of 2148). The CJAL score based on the top 10 units each also favored orthopedic spine surgeons, with 71% (3626 out of 6139) of the total score attributed to them. Using the FLCA, we observed that orthopedic spine surgeons tended to have more collaborations across countries. Additionally, while citation per article favored orthopedic spine surgeons with standard mean difference (= −0.66) and 95%CI: −0.76, −0.56, the mean CJAL score in difference (= 0.34) favored neurosurgeons with 95%CI: 0.24 0.44.

Conclusion:
Orthopedic spine surgeons have a higher number of publications, citations, and CJAL scores in spine research than those in neurosurgeons. Orthopedic spine surgeons tend to have more collaborations and coauthored papers in the field. The study highlights the differences in research productivity and collaboration patterns between the 2 authors in spine research and sheds light on potential contributing factors. The study recommends the use of FLCA for future bibliographical studies.
Clinical study of a steel cable fixation for distal tibiofibular syndesmosis injury
Authors: Yang Zuoming , Chen Junfei , Liu Xiaoming , Wang Bin , Zhao Xiaoming , Guan Pengfei 
Published: October 2023

Background:
In order to overcome the shortcomings of common surgical fixation methods for Distal Tibiofibular Syndesmosis (DTS) injuries, which include the inability to exercise early, significant surgical trauma, and the risk of loosening and breakage of implants, we have designed and implemented a new technique using steel cable fixation to treat DTS injuries.

Methods:
Twenty-six patients treated with steel cable fixation for DTS injury between March 2013 and March 2019 in the Second Hospital of Tangshan City trauma department were followed up to monitor the efficacy of treatment. There were 16 males and 10 females between the ages of 19 and 64, with a mean age of 41.81 ± 9.54 years. All patients were examined by X-ray and CT for 3 days before and after surgery. The patients were then reexamined by X-ray 6 and 9 weeks postoperatively, and by CT 1 year later. The treatment results were evaluated by comparing the distal tibiofibular anterior, middle, and posterior gap changes and the Baird-Jackson score.

Results:
The 26 patients attained good postoperative repositioning, with a fracture healing time of 2.5 to 3 months. and the Baird-Jackson score was 96 ± 2.78. After surgery, the DTS gaps observed in the CT scans taken 3 days and 1 year postoperatively in all patients were significantly reduced compared to the preoperative measurements, with statistical significance (P < .05). However, when comparing the CT scans taken 1 year postoperatively to those at 3 days postoperatively, there was no significant change in the anterior gap. The middle and posterior gaps of DTS showed a slight increase with statistical significance (P < .05), but all measurements remained within the normal range

Conclusion:
Steel cable fixation for DTS injury has the advantages of reliable fixation, early functional exercise, and reduction in the number of operations, and no adverse effects or complications were found.
Finnish Version of the Specialist Outcomes and Barriers Analysis Scale
Authors: Wright Mea Mirella Marjatta , Kvist Tarja Anneli , Mikkonen Santtu Juhani , Jokiniemi Krista Susanna 
Published: October 2023

Purpose
To evaluate the psychometric properties of the Finnish version of the Specialist Outcomes and Barriers Analysis Scale.

Design
This was a cross-sectional survey study.

Methods
Cultural adaptation of the translation and content validity of the translated instrument were assessed by expert panelists (n = 5) using the content validity index. The construct validity was assessed with principal component analysis using the survey data of Finnish registered nurses (n = 60). Scale reliability was assessed with Cronbach's α values. All study phases were conducted in 2021.

Results
The items (n = 59) of the scale were critically evaluated by the experts. The full-scale content validity was revealed as excellent (0.92). In terms of construct validity, the scale was analyzed separately for outcomes and barriers. The outcomes section revealed a 5-component structure with an overall Cronbach's α coefficient of .96, and the barriers section, a 2-component structure with an overall Cronbach's α coefficient of .82, indicating adequate reliability of the scale.

Conclusion
The Finnish version of the scale showed excellent content and construct validity. The Cronbach's α values represented adequate reliability of the Specialist Outcomes and Barriers Analysis scale when measuring nurses' perceived practice outcomes and barriers in the Finnish context.
Incidence, clearance, and factors associated with anal human papilloma virus infection among men with HIV
Authors: Zhang Jing , Sun Yu , Chen Xiaoxiao , Ye Yiwen , Shen Weiwei , Ye Xiaohong , Lin Yajun , Lin Zhebin , Tan Shigang , Gao Meiyang , Ding Yingying , He Na , Lin Haijiang , Liu Xing 
Published: October 2023

Objectives:
This study aims to estimate the incidence and persistence/clearance of anal human papilloma virus (HPV) infection and related factors among men with HIV in Taizhou, China.

Design:
A prospective cohort study.

Methods:
Men with HIV were recruited and followed up from 2016 to 2021. Questionnaire surveys were used to collect social–demographic and behavioral characteristics, and anal swabs were collected for HPV Genotyping.

Results:
A total of 675 men with HIV were recruited and followed up. After an average follow-up time of 1.75 years, HPV39 (3.8/100 person-years), HPV52 (3.6/100 person-years), HPV51 (3.1/100 person-years), HPV58 (2.5/100 person-years) and HPV16 (2.4 cases/100 person-years) in the high-risk types showed the highest incidence rate. In marriage with woman [adjusted hazard ratio (aHR) = 0.44, 95% confidence interval (CI) 0.20–0.99] showed an inverse association with HPV incidence, while bisexuality or undetermined sexual orientation (aHR = 2.62, 95% CI 1.08–6.36) showed a positive association. For those infected at baseline, the top three high-risk HPV with the lowest clearance density were HPV52 (32.2/100 person-years), HPV58 (38.1/100 person-years), and HPV16 (43.5/100 person-years). Daily consumption of 1–28 g alcohol (aHR = 0.62, 95% CI 0.41–0.95) showed an inverse association with HPV clearance, while illicit drug use (aHR = 3.24, 95% CI 1.59–6.59) showed a positive association.

Conclusion:
Anal HPV infection and clearance were both active in men with HIV in China. Marriage status and sexuality were associated with the incidence of HPV infection, while substance use including alcohol and illicit drug were associated with HPV clearance. More studies are needed to explore the risk factors of HPV persistence.
Preserved 2-y Liver Transplant Outcomes Following Simultaneous Thoracoabdominal DCD Organ Procurement Despite Effects on Liver Utilization Rate
Authors: Wisel Steven A. , Steggerda Justin A. , Thiessen Carrie , Roll Garrett R. , Chen Qiudong , Thomas Jason , Kaur Bhupinder , Catarino Pedro , Chikwe Joanna , Kim Irene K. 
Published: October 2023

Background.
Current techniques for donation after circulatory determination of death (DCD) heart procurement, through either direct procurement and machine perfusion or thoracoabdominal normothermic regional perfusion (NRP), have demonstrated excellent heart transplant outcomes. However, the impact of thoracoabdominal DCD (TA-DCD) heart procurement on liver allograft outcomes and utilization is poorly understood.

Methods.
One hundred sixty simultaneous heart and liver DCD donors were identified using the United Network for Organ Sharing/Organ Procurement and Transplantation Network database between December 2019 and July 2021. Liver outcomes from TA-DCD donors were stratified by heart procurement technique and evaluated for organ utilization, graft survival, and patient survival. Results were compared with abdominal-only DCD (A-DCD; n = 1332) and donation after brain death (DBD; n = 12 891) liver transplants during the study interval. Kaplan-Meier methods with log-rank testing were used to evaluate patient and graft survival.

Results.
One hundred thirty-three of 160 livers procured from TA-DCD donors proceeded to transplant. TA-DCD donors were younger (mean 28.26 y; P < 0.0001) with lower body mass index (mean 26.61; P < 0.0001) than A-DCD and DBD donors. TA-DCD livers had equivalent patient survival ( P = 0.893) and superior graft survival (P = 0.009) compared with A-DCD. TA-DCD livers had higher rates of organ discard for long warm ischemia time (37.0%) than A-DCD (20.5%) and DBD (0.5%; P < 0.0001), with direct procurement and machine perfusion procurements leading to a higher discard rate (18.5%) than NRP procurements (7.4%).

Conclusions.
Liver transplants after TA-DCD donation demonstrated equivalent patient outcomes and excellent graft outcomes. NRP procurements resulted in the lowest rate of organ discard after DCD donation and may represent an optimal strategy to maximize organ utilization.
Rheinheimera oceanensis sp. nov., a novel member of the genus Rheinheimera, isolated from the West Pacific Ocean
Authors: Ren Wen-Ting , Guo Li-Li , Bu Yu-Xin , Han Chen-Hua , Zhou Peng , Wu Yue-Hong 
Published: October 2023

Two Gram-stain-negative, aerobic, non-motile and short-rod-shaped bacteria, designated as strains GL-53T and GL-15-2-5, were isolated from the seamount area of the West Pacific Ocean and identified using a polyphasic taxonomic approach. The growth of strains GL-53ᵀ and GL-15-2-5 occurred at pH 5.5–10.0, 4–40 °C (optimum at 28 °C) and 0–10.0 % NaCl concentrations (optimum at 0–5.0 %). On the basis of 16S rRNA gene sequence analysis, strains GL-53ᵀ and GL-15-2-5 exhibited the highest similarity to

Rheinheimera lutimaris

YQF-2T (98.4 %), followed by

Rheinheimera pacifica

KMM 1406T (98.1 %),

Rheinheimera nanhaiensis

E407-8T (97.4 %),

Rheinheimera aestuarii

H29T (97.4 %),

Rheinheimera hassiensis

E48T (97.2 %) and

Rheinheimera aquimaris

SW-353T (97.2 %). Phylogenetic analysis revealed that the isolates were affiliated with the genus

Rheinheimera

and represented an independent lineage. The major fatty acids were summed feature 3 (C16 : 1
ω7c and/or C16 : 1
ω6c), C16 : 0 and summed feature 8 (C18 : 1
ω7c and/or C18 : 1
ω6c). The sole isoprenoid quinone was ubiquinone 8. The major polar lipids were phosphatidylethanolamine, phosphatidylglycerol, one unidentified aminophospholipid (and one unidentified glycolipid. The DNA G+C content was 48.5 mol%. The average nucleotide identity, average amino acid identity and in silico DNA–DNA hybridization values among the genomes of strain GL-53ᵀ and the related strains in the genus

Rheinheimera

were 75.5–90.1 %, 67.5–93.9 % and 21.4–41.4 %, respectively. Based on their phenotypic, chemotaxonomic and genotypic properties, the two strains were identified as representing a novel species of the genus

Rheinheimera

, for which the name Rheinheimera oceanensis sp. nov. is proposed. The type strain is GL-53T (=KCTC 82651T=MCCC M20598T).
Mitochondrial protein C15ORF48 is a stress-independent inducer of autophagy that regulates oxidative stress and autoimmunity
Authors: Takakura Yuki , Machida Moeka , Terada Natsumi , Katsumi Yuka , Kawamura Seika , Horie Kenta , Miyauchi Maki , Ishikawa Tatsuya , Akiyama Nobuko , Seki Takao , Miyao Takahisa , Hayama Mio , Endo Rin , Ishii Hiroto , Maruyama Yuya , Hagiwara Naho , Kobayashi Tetsuya J. , Yamaguchi Naoto , Takano Hiroyuki , Akiyama Taishin , Yamaguchi Noritaka 
Published: October 2023

ABSTRACTAutophagy is primarily activated by cellular stress, such as starvation or mitochondrial damage. However, stress-independent autophagy is activated by unknown mechanisms in several cell types, such as thymic epithelial cells (TECs). Here we report that the mitochondrial protein, C15ORF48, is a critical inducer of stress-independent autophagy. Mechanistically, C15ORF48 reduces the mitochondrial membrane potential and lowers intracellular ATP levels, thereby activating AMP-activated protein kinase and its downstream Unc-51-like kinase 1. Interestingly, C15ORF48 induction of autophagy upregulates intracellular glutathione levels, promoting cell survival by reducing oxidative stress. Mice deficient inC15orf48showed a reduction in stress-independent autophagy in TECs, but not in typical starvation-induced autophagy in skeletal muscles. Moreover,C15orf48−/–mice developed autoimmunity, which is consistent with the fact that the stress-independent autophagy in TECs is crucial for the thymic self-tolerance. These results suggest that C15ORF48 induces stress-independent autophagy, thereby regulating oxidative stress and self-tolerance.
Using financial resilience to grow business amidst adversities
Authors: Nassuna Agnes Noelin , Ntamu Diana Nandagire , Kikooma Julius , Mayanja Samuel Ssekajja , Basalirwa Edith 
Published: October 2023

PurposeThis paper investigates financial resilience within selected micro small and medium enterprises (MSMEs) and how it is used as a growth tool amidst coronavirus disease 2019 (COVID-19) threats.Design/methodology/approachAn appreciative inquiry qualitative approach using a positive orientation with a case study design instead of the conventional problem-oriented approach was used. It focuses on successful MSMEs that experienced growth amidst the first wave of COVID-19 despite the large number of MSMEs that were affected negatively by the pandemic.FindingsThe results indicate that the MSMEs that were growing at an epic rate during COVID-19 exhibited financial resilience due to savings, innovative leadership, financial knowledge, experience and social capital. These businesses maintained client relationships and accessed financial capital.Research limitations/implicationsThe study was qualitative based on a few cases.Practical implicationsBusiness owners/managers should learn financial literacy, entrepreneurial skills and leadership skills and build social capital which are tenets of financial resilience during turbulent times.Originality/valueThe study contributes to the continuity of MSMEs in developing economies during times of uncertainty.
Resistance exercise: competition, coopetition and collective action among self-employed personal trainers in the UK
Authors: Harvey Geraint , Li Jia , Wintersberger Daniel 
Published: October 2023

Purpose The article explores the potential for self-employed personal trainers (SEPTs) to resist exploitation by gyms, with a focus on the attitudes of SEPTs towards trade unions and collective action.Design/methodology/approachThis article is based on a multiple-method study with qualitative data drawn from participant observation and interviews and quantitative data from a questionnaire survey. The data were collected in 2018.FindingsThe potential for individual resistance to exploitation among SEPTs is limited. However, attitudes towards a collective response were largely positive, albeit there is certainly no consensus agreement on the value of trade unions. The logic of coopetition is applied to explain the issues on which trade unions might organize SEPTs.Research limitations/implicationsThe study suggests coopetition as an organizing logic for highly individualized self-employed workers in intense proximal competition with one another. However, the research presented in this article was undertaken with a unique group of solo self-employed workers. Further study is required to demonstrate the applicability of these findings.Practical implicationsThe commercialization of work poses a threat to traditional employment and trade unions. It is crucial that trade unions represent the interests of all workers by focusing on workers who do not traditionally form the vanguard of its membership (e.g. dependent workers and the falsely self-employed). The study illustrates the way in which trade unions can organize micro-entrepreneurs.Social implicationsCoopetitive representation whereby micro-entrepreneurs collaborate to resist exploitation while remaining independent has the potential to change the perspectives and values of entrepreneurs.Originality/valueThe article assesses the potential of organizing a highly individualized and competitive self-employed worker. Coopetitive representation is presented as distinct from other approaches to representation and as a means of trade union revitalization.