bluuebunny/crossref_metadata_2025_split huggingface dataset:
Synergistic Optimization of Morphology and Vacancies on Diatomic Rhodium Catalysts Dispersed on Carbon Nitride for Efficient Photocatalytic Reduction of CO2
Authors: Ma Xiangying , Chen Qifeng , Han Changming , Zhou Shiwen , Li Zulong , Liu Jiahui , Hu Fengtao , Wang Jiaao , Wang Nannan , Zhu Yanqiu , Zhu Jinliang 
Published: November 2023

AbstractDiatomic site catalysts (DAC) have better performance with higher metal content and more flexible active sites compared with single atomic site catalysts (SAC). Herein, the authors for the first time achieved Rh2 DAC on loose porous g‐C3N4 hollow nanospheres with N‐vacancies and applied to photocatalytic CO2 reduction reaction, overcoming the current limitations of the low electron–hole recombination rate and prolong the lifetime of the photogenerated carrier. The high specific surface area of hollow nanosphere facilitates the uniform dispersion and anchoring of Rh2 diatomic pairs, while the N‐vacancies induce a stable 3N/Rh‐Rh/1N2C coordination between the carrier and Rh2 diatomic pairs. The local charges on the support framework with N vacancies tend to be transferred to Rh2 diatomic site by 3N/Rh‐Rh/1N2C bridge, which made the charge enriched Rh2 diatomic site become the active center of reaction, enhance charge separation efficiency of Rh2/HCNS‐Nv. Compared with Rh1 SAC, further Density Functional Theory (DFT) calculation confirms that Rh2 DAC can effectively stabilize rate‐limiting intermediates CHO*, and well weaken the C─O bond strength in CH3O* species, promote the generation and separation of CH4, resulting in high CO2 reduction efficiency and CH4 electron selectivity of up to 91.65%.
Coaxial 4D Printing of Vein‐Inspired Thermoresponsive Channel Hydrogel Actuators
Authors: Podstawczyk Daria , Nizioł Martyna , Śledzik Piotr , Simińska‐Stanny Julia , Dawiec‐Liśniewska Anna , Shavandi Amin 
Published: November 2023

AbstractAlthough significant progress has been made in coaxial printing of vascularized tissue models, this technique has not yet been used to fabricate stimulus‐responsive scaffolds capable of shape change over time. Here, a new method of direct ink printing (DIP) is proposed with a coaxial nozzle, coaxial 4D printing, enabling the manufacturing of thermoresponsive constructs embedded with a network of interconnected channels. In this approach, a poly(N‐isopropylacrylamide) (PNIPAAm)‐based thermoink is coaxially extruded into either core/sheath microfibers or microtubes. PNIPAAm renders a hydrogel temperature‐sensitive and endows it with a shape‐morphing property both at the micro‐ and macroscale. Specifically, the lumen diameter of the microtubes can be controlled by temperature by 30%. The macrostructural soft actuators can undergo programmed and reversible temperature‐dependent shape changes due to the structural anisotropy of the hydrogel. The permeability tests demonstrate that the hydrogel can possess enough strength to maintain the hollow channels without breaking. In vitro tests confirm the biocompatibility of the material with EA.hy926 cells, paving the avenue for new perfusable soft robots, or active implants. Finally, microalgae Chlamydomonas reinhardtii is combined with the hydrogels to fabricate materials having functions of both living microorganisms and stimuli‐responsive polymers toward creating engineered living materials (ELMs) with a vein‐like geometry.
Metal–Organic Framework Based Nanozyme System for NLRP3 Inflammasome‐Mediated Neuroinflammatory Regulation in Parkinson's Disease
Authors: Li Qing , Ding Xin , Chang Zhaohui , Fan Xiaowan , Pan Jiangpeng , Yang Ying , Li Xin , Jiang Wei , Fan Kelong 
Published: November 2023

AbstractNeuroinflammation is associated with a series of pathological symptoms in Parkinson's disease (PD), including α‐synuclein aggregation and dopaminergic neuronal death. The NOD‐like receptor protein 3 (NLRP3) inflammasome plays a crucial role in neuroinflammation at the lesion site and is a promising target for PD treatment. In this study, a nanoscale metal‐organic framework (Zr‐FeP MOF) based nanozyme is fabricated using Fe‐5,10,15,20‐tetra (4‐carboxyphenyl) porphyrin (Fe‐TCPP) and Zr6 cluster as ligands. The Zr‐FeP MOF is subsequently encapsulated with mannitol (Man)‐liposome, resulting in the formation of Zr‐FeP MOF@Man liposome (MOF@Man Liposome) nanozyme system. The in vitro studies show that this nanozyme system is effective in relieving the formation of NLRP3 inflammasome and mitochondrial dysfunction. In mouse models of PD, the nanozyme system demonstrates a significant blood–brain barrier‐crossing capability attributed to the Man‐mediated brain targeting. Additionally, transcriptomic and biochemical studies show that the nanozyme system effectively inhibits the formation and assembly of inflammasome components, mitigating the activation of glial cells and neuroinflammatory response, and ultimately regulating the pathological symptoms of PD effectively.
Modular Self‐Assembling Dendrimer Nanosystems for Magnetic Resonance and Multimodality Imaging of Tumors
Authors: Ding Ling , Lyu Zhenbin , Perles‐Barbacaru Teodora‐Adriana , Huang Adela Ya‐Ting , Lian Baoping , Jiang Yifan , Roussel Tom , Galanakou Christina , Giorgio Suzanne , Kao Chai‐Lin , Liu Xiaoxuan , Iovanna Juan , Bernard Monique , Viola Angèle , Peng Ling 
Published: November 2023

AbstractBioimaging is a powerful tool for diagnosing tumors but remains limited in terms of sensitivity and specificity. Nanotechnology‐based imaging probes able to accommodate abundant imaging units with different imaging modalities are particularly promising for overcoming these limitations. In addition, the nanosized imaging agents can specifically increase the contrast of tumors by exploiting the enhanced permeability and retention effect. A proof‐of‐concept study is performed on pancreatic cancer to demonstrate the use of modular amphiphilic dendrimer‐based nanoprobes for magnetic resonance (MR) imaging (MRI) or MR/near‐infrared fluorescence (NIRF) multimodality imaging. Specifically, the self‐assembly of an amphiphilic dendrimer bearing multiple Gd3+ units at its terminals, generates a nanomicellar agent exhibiting favorable relaxivity for MRI with a good safety profile. MRI reveals an up to two‐fold higher contrast enhancement in tumors than in normal muscle. Encapsulating the NIRF dye within the core of the nanoprobe yields an MR/NIRF bimodal imaging agent for tumor detection that is efficient both for MRI, at Gd3+ concentrations 1/10 the standard clinical dose, and for NIRF imaging, allowing over two‐fold stronger fluorescence intensities. These self‐assembling dendrimer nanosystems thus constitute effective probes for MRI and MR/NIRF multimodality imaging, offering a promising nanotechnology platform for elaborating multimodality imaging probes in biomedical applications.
Terahertz Liquid Biosensor Based on A Graphene Metasurface for Ultrasensitive Detection with A Quasi‐Bound State in the Continuum
Authors: Huang Chengcheng , Liang Lanju , Chang Pengying , Yao Haiyun , Yan Xin , Zhang Yonggang , Xie Yiyang 
Published: November 2023

AbstractThe concept of a quasi‐bound state in a continuum (QBIC) has garnered significant attention in various fields such as sensing, communication, and optical switching. Within metasurfaces, QBICs offer a reliable platform that enables sensing capabilities through potent interactions between local electric fields and matter. Herein, a novel terahertz (THz) biosensor based on the integration of QBIC with graphene is reported, which enables multidimensional detection. The proposed biosensor is distinctive because of its ability to discern concentrations of ethanol and N‐methylpyrrolidone in a wide range from 100% to 0%, by monitoring the changes in the resonance intensity and maximum wavelet coefficient. This approach demonstrates an excellent linear fit, which ensures robust quantitative analysis. The remarkable sensitivity of our biosensor enables it to detect minute changes in low‐concentration solutions, with the lowest detection concentration value (LDCV) of 0.21 pg mL−1. 2D wavelet coefficient intensity cards are effectively constructed through continuous wavelet transforms, which presents a more accurate approach for determining the concentration of the solution. Ultimately, the novel sensing platform offers a host of advantages, including heightened sensitivity and reusability. This pioneering approach establishes a new avenue for liquid‐based terahertz biosensing.
Marriage of a Dual‐Plasmonic Interface and Optical Microfiber for NIR‐II Cancer Theranostics
Authors: Wu Haotian , Chen Pengwei , Zhan Xundi , Lin Kaiyue , Hu Tao , Xiao Aoxiang , Liang Jiaxuan , Huang Yugang , Huang Yunyun , Guan Bai‐Ou 
Published: November 2023

AbstractThe use of light as a powerful tool for disease treatment has introduced a new era in tumor treatment and provided abundant opportunities for light‐based tumor theranostics. This work reports a photothermal theranostic fiber integrating cancer detection and therapeutic functions. Its self‐heating effect can be tuned at ultralow powers and used for self‐heating detection and tumor ablation. The fiber, consisting of a dual‐plasmonic nanointerface and an optical microfiber, can be used to distinguish cancer cells from normal cells, quantify cancer cells, perform hyperthermal ablation of cancer cells, and evaluate the ablation efficacy. Its cancer cell ablation rate reaches 89% in a single treatment. In vitro and in vivo studies reveal quick, deep‐tissue photonic hyperthermia in the NIR‐II window, which can markedly ablate tumors. The marriage of a dual‐plasmonic nanointerface and an optical microfiber presents a novel paradigm in photothermal therapy, offering the potential to surmount the challenges posed by limited light penetration depth, nonspecific accumulation in normal tissues, and inadvertent damage in current methods. This work thus provides insight for the exploration of an integrated theranostic platform with simultaneous functions in cancer diagnostics, therapeutics, and postoperative monitoring for future practical applications.
Optical Microfiber Coated with WS2‐Supported Gold Nanobipyramids: Ultrasensitive Detecting Prostate Cancer Extracellular Vesicles in Complex Human Samples
Authors: Li Hongtao , Wu Hao , Lu Liang , Zhang Jialong , Wang Xu , Wang Weisheng , Zheng Aiyun , Liang Lili , Sun Huojiao , Zheng Jinrong , Yuan Hao , Cao Zhigang , Yu Qi , Yu Benli , Wang Hongzhi 
Published: November 2023

AbstractUltrasensitive and rapid detection of single extracellular vesicles (EV) in complex biological samples requires a biosensor that possesses remarkable specificity, cost‐effectiveness, and ease of use; however, this remains a big challenge owing to the small size and high heterogeneity of EV in samples. Although reported biosensors can detect biomarkers in complex biological samples, tedious preprocessing procedures, low sensitivity, and expensive and complicated production hinder their use in early‐stage cancer diagnostics. To address these issues, an optical microfiber modified with WS2‐supported gold nanobipyramid (Au NBPs) nanointerfaces for the ultrasensitive assay of prostate cancer (PC) exosomes is proposed. Owing to the strong localized surface plasmon resonance (LSPR) hotspots of the Au NBPs coupled with the WS2 nanointerface, the sensor could ultrasensitively detect exosomes with an ultralow limit of detection (LODs) of 23.5 particles mL−1 in phosphate‐buffered saline (PBS) solution and 570.6 particles mL−1 in 10% serum. The LOD of 23.5 particles mL−1 is two orders of magnitude lower than those reported for other cutting‐edge techniques. Based on this sensing scheme, the sensor can distinguish PC serum from healthy serum, and successfully diagnose patients’ whole blood by capturing and sizing a single bioparticle. This work presents a novel method for analyzing whole blood with ultrahigh sensitivity.
Motile Living Biobots Self‐Construct from Adult Human Somatic Progenitor Seed Cells
Authors: Gumuskaya Gizem , Srivastava Pranjal , Cooper Ben G. , Lesser Hannah , Semegran Ben , Garnier Simon , Levin Michael 
Published: November 2023

AbstractFundamental knowledge gaps exist about the plasticity of cells from adult soma and the potential diversity of body shape and behavior in living constructs derived from genetically wild‐type cells. Here anthrobots are introduced, a spheroid‐shaped multicellular biological robot (biobot) platform with diameters ranging from 30 to 500 microns and cilia‐powered locomotive abilities. Each Anthrobot begins as a single cell, derived from the adult human lung, and self‐constructs into a multicellular motile biobot after being cultured in extra cellular matrix for 2 weeks and transferred into a minimally viscous habitat. Anthrobots exhibit diverse behaviors with motility patterns ranging from tight loops to straight lines and speeds ranging from 5–50 microns s−1. The anatomical investigations reveal that this behavioral diversity is significantly correlated with their morphological diversity. Anthrobots can assume morphologies with fully polarized or wholly ciliated bodies and spherical or ellipsoidal shapes, each related to a distinct movement type. Anthrobots are found to be capable of traversing, and inducing rapid repair of scratches in, cultured human neural cell sheets in vitro. By controlling microenvironmental cues in bulk, novel structures, with new and unexpected behavior and biomedically‐relevant capabilities, can be discovered in morphogenetic processes without direct genetic editing or manual sculpting.
CYTOR Facilitates Formation of FOSL1 Phase Separation and Super Enhancers to Drive Metastasis of Tumor Budding Cells in Head and Neck Squamous Cell Carcinoma
Authors: Wang Wenjin , Yun Bokai , Hoyle Rosalie G , Ma Zhikun , Zaman Shadid Uz , Xiong Gan , Yi Chen , Xie Nan , Zhang Ming , Liu Xiqiang , Bandyopadhyay Dipankar , Li Jiong , Wang Cheng 
Published: November 2023

AbstractTumor budding (TB) is a small tumor cell cluster with highly aggressive behavior located ahead of the invasive tumor front. However, the molecular and biological characteristics of TB and the regulatory mechanisms governing TB phenotypes remain unclear. This study reveals that TB exhibits a particular dynamic gene signature with stemness and partial epithelial‐mesenchymal transition (p‐EMT). Importantly, nuclear expression of CYTOR is identified to be the key regulator governing stemness and the p‐EMT phenotype of TB cells, and targeting CYTOR significantly inhibits TB formation, tumor growth and lymph node metastasis in head and neck squamous cell carcinoma (HNSCC). Mechanistically, CYTOR promotes tumorigenicity and metastasis of TB cells by facilitating the formation of FOSL1 phase‐separated condensates to establish FOSL1‐dependent super enhancers (SEs). Depletion of CYTOR leads to the disruption of FOSL1‐dependent SEs, which results in the inactivation of cancer stemness and pro‐metastatic genes. In turn, activation of FOSL1 promotes the transcription of CYTOR. These findings indicate that CYTOR is a super‐lncRNA that controls the stemness and metastasis of TB cells through facilitating the formation of FOSL1 phase separation and SEs, which may be an attractive target for therapeutic interventions in HNSCC.
Multilevel Reset Dependent Set of a Biodegradable Memristor with Physically Transient
Authors: Shaikh Mohammad Tauquir Alam Shamim , Nguyen Tan Hoang Vu , Jeon Ho Jung , Prasad Chowdam Venkata , Kim Kyong Jae , Jo Eun Seo , Kim Sangmo , Rim You Seung 
Published: November 2023

AbstractThe electronic device, with its biocompatibility, biodegradability, and ease of fabrication process, shows great potential to embed into health monitoring and hardware data security systems. Herein, polyvinylpyrrolidone (PVP) biopolymer is presented as an active layer, electrochemically active magnesium (Mg) as a metal electrode, and chitosan‐based substrate (CHS) to fabricate biocompatible and biodegradable physically transient neuromorphic device (W/Mg/PVP/Mg/CHS). TheI–Vcurve of device is non‐volatile bipolar in nature and shows a unique compliance‐induced multilevel RESET‐dependent‐SET behavior while sweeping the compliance current from a few microamperes to milliamperes. Non‐volatile and stable switching properties are demonstrated with a long endurance test (100 sweeps) and retention time of over 104 s. The physically transient memristor (PTM) has remarkably high dynamic RON/ROFF(ON/OFF state resistance) ratio (106Ω), and when placed in deionized (DI) water, the device is observed to completely dissolve within 10 min. The pulse transient measurements demonstrate the neuromorphic computation capabilities of the device in the form of excitatory post synaptic current (EPSC), potentiation, depression, and learning behavior, which resemble the biological function of neurons. The results demonstrate the potential of W/Mg/PVP/Mg/CHS device for use in future healthcare and physically transient electronics.
Long Cycle Life for Rechargeable Lithium Battery using Organic Small Molecule Dihydrodibenzo[c,h][2,6]naphthyridine‐5,11‐dione as a Cathode after Isoindigo Pigment Isomerization
Authors: Yang Mingcong , Hu Wei , Li Jun , Chen Tao , Zhao Shiqiang , Chen Xi'an , Wang Shun , Jin Huile 
Published: November 2023

AbstractSustainability and adaptability in structural design of the organic cathodes present promises for applications in alkali metal ion batteries. Nevertheless, a formidable challenge lies in their high solubility in organic electrolytes, particularly for small molecular materials, impeding cycling stability and high capacity. This study focuses on the design and synthesis of organic small molecules, the isomers of (E)‐5,5′‐difluoro‐[3,3′‐biindolinylidene]‐2,2′‐dione (EFID) and 3,9‐difluoro‐6,12‐dihydrodibenzo [c, h][2,6]naphthyridine‐5,11‐dione (FBND). While EFID, characterized by a less π‐conjugated structure, exhibits subpar cycling stability in lithium‐ion batteries (LIBs), intriguingly, another isomer, FBND, demonstrates exceptional capacity and cycling stability in LIBs. FBND delivers a remarkable capacity of 175 mAh g−1 at a current density of 0.05 A g−1 and maintains excellent cycling stability over 2000 cycles, retaining 90% of its initial capacity. Furthermore, an in‐depth examination of redox reactions and storage mechanisms of FBND are conducted. The potential of FBND is also explored as an anode in lithium‐ion batteries (LIBs) and as a cathode in sodium‐ion batteries (SIBs). The FBND framework, featuring extended π‐conjugated molecules with an imide structure compared to EFID, proves to be an excellent material template to develop advanced organic small molecular cathode materials for sustainable batteries.
Blueprint for community emergency department pediatric simulation
Authors: Kaur Snimarjot , Lynders William , Goldman Michael , Bruno Christie , Morin Juliana , Maruschock Scott , Auerbach Marc 
Published: November 2023

AbstractBackgroundGaps in quality of pediatric emergency care have been noted in community emergency departments (CEDs), where >85% of children receive care. In situ simulation provides opportunities for hands‐on experiences and can help close these gaps. We aimed to develop, implement, and evaluate an innovative, replicable, and scalable pediatric in situ simulation‐based CED curriculum, under the leadership of a local colleague, through collaborative approach with a regional academic medical center (AMC).MethodsKern's model was used as follows: problem identification and general needs assessment—pediatric readiness assessment and discussions with CED physician and nursing leadership; targeted needs assessment—review of recent pediatric transfer cases; goals and objectives—enhance pediatric knowledge and skills of interprofessional teams and detect latent safety threats; educational strategies—codeveloped by CED and AMC, included prelearning using podcasts and videos, simulation and facilitated debriefing, resource sharing after simulations; implementation—3‐h simulation sessions facilitated in person by the CED team and remotely by AMC (leadership required participation and paid staff); and evaluation and feedback—retrospective pre–post survey, Simulation Effectiveness Tool–Modified (SET‐M), Net Promoter Score (NPS), and review/feedback meetings.ResultsBased on needs assessment, the selected cases included newborn resuscitation, seizure, asthma, and tetrahydrocannabinol ingestion causing altered mental sensorium in a child. Twenty‐four 3‐h simulation sessions were conducted over 1 year. A total of 168 participants completed the sessions, while 75 participants (54.7% nurses, 22.7% physicians, and others) completed feedback surveys. Seventy‐six percent of participants reported completing presimulation education material. Participants reported improved skills at appropriately evaluating a critically ill newborn and critically ill infant/toddler and improved teamwork during the care of a pediatric patient. The majority agreed that simulation was effective in teaching pediatric resuscitation. The NPS was 84% (excellent).ConclusionsA locally facilitated CED in situ simulation curriculum was successfully developed and implemented under local leadership, with remote collaboration by AMC. The curriculum was well received and effective.
C7‐Regioselective C−H Fluorination of Benzotriazole Amides and Sulfonamides with NFSI under Metal‐Free Conditions
Authors: Li Chengqian , Fan Shengyu , Wang Zhuo , Song Zhiguang 
Published: November 2023

AbstractThe first metal‐free catalyzed C−H selective fluorination of benzotriazole amides and sulfonamide derivatives was achieved at the C‐7 position using NFSI (N‐fluorobenzenesulfonymide) as the fluorine source. The control experiment showed that the reaction underwent a free radical process that tolerated an excellent range of substrates with mild to good yields (>46 examples, yield up to 71 %).
Boosting Low‐Temperature CO2 Hydrogenation over Ni‐based Catalysts by Tuning Strong Metal‐Support Interactions
Authors: Ye Runping , Ma Lixuan , Hong Xiaoling , Reina Tomas Ramirez , Luo Wenhao , Kang Liqun , Feng Gang , Zhang Rongbin , Fan Maohong , Zhang Riguang , Liu Jian 
Published: November 2023

AbstractRational design of low‐cost and efficient transition‐metal catalysts for low‐temperature CO2 activation is significant and poses great challenges. Herein, a strategy via regulating the local electron density of active sites is developed to boost CO2 methanation that normally requires >350 °C for commercial Ni catalysts. An optimal Ni/ZrO2 catalyst affords an excellent low‐temperature performance hitherto, with a CO2 conversion of 84.0 %, CH4 selectivity of 98.6 % even at 230 °C and GHSV of 12,000 mL g−1 h−1 for 106 h, reflecting one of the best CO2 methanation performance to date on Ni‐based catalysts. Combined a series of in situ spectroscopic characterization studies reveal that re‐constructing monoclinic‐ZrO2 supported Ni species with abundant oxygen vacancies can facilitate CO2 activation, owing to the enhanced local electron density of Ni induced by the strong metal‐support interactions. These findings might be of great aid for construction of robust catalysts with an enhanced performance for CO2 emission abatement and beyond.