bluuebunny/crossref_metadata_2025_split huggingface dataset:
Beyond working hours: the association between long working hours, the use of work-related communication devices outside regular working hours, and anxiety symptoms
Authors: Kim Shinhyeong , Ham Seunghon , Kang Seong-Kyu , Choi Won-Jun , Lee Wanhyung 
Published: December 2023

Abstract
Objectives: The present study aimed to identify and compare the associations between long working hours and use of work-related communication devices outside regular working hours and anxiety symptoms, thereby providing insight into redefining working hours.
Methods: Based on the cross-sectional data from the sixth Korean Working Conditions Survey (KWCS), specifically the responses from 46 055 workers, the use of work-related communication devices outside of regular working hours, long working hours, and anxiety symptoms were assessed. To investigate the associations between using work-related communication devices outside regular working hours or long working hours with anxiety symptoms, odds ratios (ORs) and 95% CIs were calculated using multiple logistic regression models.
Results: Among 46 055 participants, 25 659 (55.7%) used work-related communication devices outside working hours, 8145 (17.7%) worked long hours, and 2664 (5.8%) experienced anxiety symptoms. Compared with the reference group, those who used work-related communication devices outside regular working hours without working long hours, had higher OR of anxiety symptoms (OR: 2.18; 95% CI, 1.97-2.41) than those who worked long hours without using work-related communication devices during off-hours (OR: 1.32; 95% CI, 1.09-1.59). Furthermore, the group that both worked long hours and used work-related communication devices outside working hours exhibited the highest OR of anxiety symptoms (OR: 2.57; 95% CI, 2.24-2.97).
Conclusions: Using work-related communication devices outside regular working hours is associated with a higher risk of anxiety symptoms compared with long working hours. This result suggests that using work-related devices outside regular working hours, in addition to regular work time, should be considered when redefining working hours.
Association between health-related physical fitness indicators and working ability: a systematic review
Authors: Leso Veruscka , Scalfi Luca , Giordano Angela , Reppuccia Liberata , Guarino Davide , Fedele Mauro , Iavicoli Ivo 
Published: December 2023

Abstract
Objectives: Work ability (WA) reflects a balance between work demands and an individual’s ability to meet them. It is influenced by several occupational and health-related factors including the individual’s physical fitness (PF). Therefore, the aim of the present study was to provide an overview of the possible relationship between PF measures and the individual’s WA.
Methods: A systematic review of studies published up to December 1, 2022 and available in PubMed, Scopus, and ISI Web of Science databases, was performed. Results have been summarized according to the specific PF parameter explored.
Results: The 14 reviewed studies, enrolling 47 to 1005 workers, all showed a satisfactory methodological quality. Some positive evidence emerged for a possible association between changes in aerobic capacity, walking speed, balance, flexibility, muscle strength, and WA perception. However, the limited number of studies, their cross-sectional design, the different PF performance indicators, populations, and job tasks explored prevented definite conclusions.
Conclusions: Future longitudinal studies should be planned to confirm such positive results and identify PF indicators better predictive for changes in the WA of employees engaged in specific job tasks, particularly in physically demanding activities. This may be helpful to include PF performance tests in occupational health practice as an integrated part of risk assessment and management strategies as well as in health and well-being promotion plans.
Sexual function scores are associated with arterial stiffness in postmenopausal women
Authors: Armeni Anastasia , Armeni Eleni , Augoulea Areti , Delialis Dimitrios , Angelidakis Lasthenis , Papaioannou Maria , Kaparos George , Alexandrou Andreas , Georgopoulos Neoklis , Vlahos Nicolaos , Stamatelopoulos Kimon , Lambrinoudaki Irene 
Published: December 2023

Abstract

Background
Female sexual dysfunction (FSD) has been suggested to be correlated with the burden of cardiovascular risk factors.

Aim
We aimed to evaluate the possible association between functional indices of vascular function and FSD scores in apparently healthy postmenopausal women.

Methods
This cross-sectional study included 116 postmenopausal women who underwent assessment of endothelial function with measurement of flow-mediated dilation (FMD) of the branchial artery and arterial stiffness estimation with measurement of the carotid-femoral pulse wave velocity (PWV). We used the Greene Climacteric Scale to evaluate vasomotor symptomatology, the Female Sexual Function Index (FSFI) to evaluate FSD and the Beck Depression Inventory to evaluate mood disorder. Low sexual function was defined as an FSFI score &lt;26.55.

Outcomes
These included FSFI and low sexual function scores as well as measures of PWV and FMD.

Results
Sexual function scores were associated with measures of blood pressure (normal vs low sexual function; systolic blood pressure: 120.2 ± 15.0 mm Hg vs 113.4 ± 14.6 mm Hg; analysis of covariance P = .026; diastolic blood pressure: 75.9 ± 10.5 mm Hg vs 70.3 ± 9.9 mm Hg; analysis of covariance P = .012; both adjusted for age, body mass index, current smoking, and PWV). Systolic blood pressure, but not diastolic blood pressure, was associated with FSFI (B = 0.249, P = .041) and PWV (B = 0.392, P &lt; .001). PWV measures were associated with FSFI (B = −0.291, P = .047) and pulse pressure (B = 0.355, P = .017). FMD measures were also associated with FSFI (B = 0.427, P = .033). All models were adjusted for age, body mass index, current smoking, insulin resistance, vasomotor symptomatology, and Beck Depression Inventory.

Clinical implications
Our findings demonstrate that lower scores of sexual function are associated with deteriorated vascular function mainly manifested as arterial stiffening, further contributing to systolic blood pressure changes.

Strengths and limitations
The strength of this study is the carefully selected healthy sample of postmenopausal women, with simultaneous assessment of climacteric symptomatology and mood disorders. The limitations include the small sample size, the cross-sectional design, and the recruitment of consecutive outpatients of a university menopause clinic.

Conclusion
Longitudinal studies and interventions to improve FSD should further assess the clinical relevance of these findings.
The neutral hydrogen mass in galaxies estimated via optical spectroscopy
Authors: Bizyaev Dmitry 
Published: December 2023

ABSTRACT
We propose to employ emission line luminosities obtained via optical spectroscopy to estimate the content of neutral hydrogen (H i) in galaxies. We use the optical spectroscopy data from the Mapping of Nearby Galaxies at APO (MaNGA) survey released in the frames of public DR17 of the Sloan Digital Sky Survey (SDSS). We compare the H i mass estimated by us for a large sample of SDSS/MaNGA galaxies with direct H i measurements from the Arecibo Legacy Fast ALFA survey and find a tight correlation between the masses with the correlation coefficient (CC) of 0.91 and the rms scatter of 0.15 dex for the logarithmic mass. The obtained relationship is verified via another sample of MaNGA galaxies with H i masses measured with the Green Bank Telescope. Despite the coarser angular resolution of the radio data, the relation between the estimated and measured directly H i mass is tight as well – in this case CC = 0.74 and the rms is 0.29 dex. The established relations allow us to estimate the total mass of neutral hydrogen as well as the spatial distribution of H i surface density in galaxies from optical spectroscopic observations only in a simple and efficient way.
Real-world safety and effectiveness of mepolizumab for patients with eosinophilic granulomatosis with polyangiitis in Japan: A 48-week interim analysis of the MARS study
Authors: Ishii Tomonori , Kunishige Hideaki , Kobayashi Tamami , Hayashi Etsuko , Komatsubara Masaki , Ishii Takeo , Alfonso-Cristancho Rafael , Tamaoki Jun , Howarth Peter 
Published: December 2023

ABSTRACT

Objectives
The objective of the study is to assess real-world, long-term safety/effectiveness of mepolizumab for eosinophilic granulomatosis with polyangiitis (EGPA) in Japan.

Methods
The Mepolizumab long-term study to Assess Real-world Safety and effectiveness of EGPA in Japan (MARS) (GSK ID: 213684/NCT04551989) is an ongoing 96-week study of patients with EGPA who received four-weekly mepolizumab 300 mg subcutaneously for ≥96 weeks before study entry (baseline) and continued treatment. This interim analysis included safety from baseline to Week 48 (observation period) and clinical outcomes before mepolizumab and during the observation period.

Results
Of 118 patients enrolled, 29% (34/118) experienced adverse events (AEs), of which 13% (15/118) experienced serious AEs; none were considered mepolizumab related. The median oral corticosteroid (OCS) dose decreased from 6.9 (pre-mepolizumab) to 3.0 (baseline) and 2.0 mg/day (Weeks 45–48); the proportion of patients receiving no OCS increased from 8% to 32% and 38%, respectively. Patients experiencing clinical symptoms decreased from 94% (pre-mepolizumab) to 73% (baseline) and 67% (Week 48). During the observation period, 5% of patients experienced EGPA relapse; the rates of EGPA-related hospitalisations, EGPA-related emergency room/unscheduled visits, and asthma exacerbations were 0.05, 0.09, and 0.08 event/person-year, respectively.

Conclusions
The results of mepolizumab treatment for ≥144 weeks (before baseline plus observation) were consistent with the known safety profile and allowed OCS dose reduction while improving disease control versus pre-treatment among patients with EGPA.
The 5th Kidney Cancer Research Summit: Research Accelerating Cures for Renal Cell Carcinoma in 2023
Authors: Choueiri Toni K , Pal Sumanta K , Lewis Bryan , Poteat Susan , Pels Kevin , Hammers Hans 
Published: December 2023

Abstract
The 5th Kidney Cancer Research Summit was a hybrid event hosted in Boston, MA in July 2023. As in previous editions, the conference attracted a wide representation of global thought leaders in kidney cancer spanning all stages of clinical and laboratory research. Sessions covered tumor metabolism, novel immune pathways, advances in clinical trials and immunotherapy, and progress toward biomarkers. The abstract presentations were published as a supplement in The Oncologist (https://academic.oup.com/oncolo/issue/28/Supplement_1). Aiming to be more concise than comprehensive, this commentary summarizes the most important emerging areas of kidney cancer research discussed and debated among the stakeholders at the conference, with relevant updates that have occurred since.
High-pressure xenon gas time projection chamber with scalable design and its performance around the Q value of 136Xe double-beta decay
Authors: Yoshida Masashi , Nakamura Kazuhiro , Akiyama Shinichi , Ban Sei , Hikida Junya , Hirose Masanori , Ichikawa Atsuko K , Iwashita Yoshihisa , Kashino Yukimasa , Kikawa Tatsuya , Minamino Akihiro , Miuchi Kentaro , Nakajima Yasuhiro , Nakamura Kiseki D , Nakaya Tsuyoshi , Obara Shuhei , Sakashita Ken , Sekiya Hiroyuki , Shinagawa Hibiki , Sugashima Bungo , Urano Soki 
Published: December 2023

Abstract
We have been developing a high-pressure xenon gas time projection chamber (TPC) called AXEL (A Xenon ElectroLuminescence detector) to search for neutrinoless double-beta (0νββ) decay of 136Xe. The unique feature of this TPC is the electroluminescence light collection cell (ELCC), the part designed to detect ionization electrons. The ELCC is composed of multiple units, and one unit covers 48.5 cm2. A 180 L size prototype detector with 12 units, 672 channels, of the ELCC was constructed and operated with 7.6 bar natural xenon gas to evaluate the performance of the detector around a Q value of 136Xe 0νββ. The obtained FWHM energy resolution is $0.73 \pm 0.11\%$ at 1836 keV. This corresponds to $0.60 \pm 0.03\%$ to $0.70 \pm 0.21\%$ of the energy resolution at a Q value of 136Xe 0νββ. This result shows the scalability of the AXEL detector with the ELCC while maintaining a high energy resolution. Factors determining the energy resolution were quantitatively evaluated and the result indicates that further improvement is feasible. Reconstructed track images show distinctive structures at the endpoints of electron tracks, which will be an important feature in distinguishing 0νββ signals from gamma-ray backgrounds.
Risk of atrial fibrillation in patients with systemic sclerosis: a nationwide population-based study
Authors: Kwon Oh Chan , Han Kyungdo , Park Min-Chan 
Published: December 2023

Abstract

Objective
Atrial fibrillation (AF) is the most common arrhythmia in the general population, causing substantial economic burden, morbidity and mortality. The incidence rate and risk of AF in patients with SSc are unclear. We aimed to assess the incidence rate of AF in patients with SSc and the risk of incident AF in patients with SSc compared with the general population.

Methods
The Korean National Health Insurance Service database was used as the data source. Patients with claims data for SSc between 2010 and 2017 were extracted from the database along with 1:5 age- and sex-matched controls. The index date was the earliest date with claims data for SSc between 2010 and 2017. The follow-up duration was from the index date to 2019. Multivariable Cox proportional hazard models were used to estimate the hazard ratio (HR) and 95% CI for AF in patients with SSc.

Results
Overall, 2519 patients with SSc and 12 595 age- and sex-matched controls were included. Over a mean follow-up duration of 5.2 years (s.d. 2.6), the incidence rates of AF were 3.52 and 1.68 per 1000 person-years for patients with SSc and controls, respectively. Compared with controls, patients with SSc had a significantly higher risk of incident AF [adjusted HR 2.095 (95% CI 1.466, 2.994)].

Conclusion
Patients with SSc had a 2-fold higher risk of incident AF than controls. Given the significant economic burden, morbidity and mortality that AF poses, close monitoring for incident AF in patients with SSc is warranted.
Performance evaluation of stationary and mobile radiography systems in Indonesia
Authors: Lubis Lukmanda Evan , Satrio Michael Christian , Nasution Alimuddin , Suryanti Rini , Soejoko Djarwani Soeharso 
Published: December 2023

Abstract
An analysis and evaluation has been carried out on each test parameter contained in the compliance test of 1016 stationary and 480 mobile radiography devices compiled by the Indonesian Nuclear Energy Regulatory Agency (Badan Pengawas Tenaga Nuklir, BAPETEN) from 2019 to 2020. The data were categorised and analysed based on the devices’ age to observe the correlation of performance with the age of the X-ray machine. In addition, the implementation level of the Automatic Exposure Control (AEC) system test of the stationary radiography X-ray modality is also reviewed. The results of the evaluation showed that 89.9% of the stationary radiography devices unconditionally pass the test, 5.2% are in the status of ‘conditional pass’ and 4.9% fail the test. On the other hand, 84.8% of mobile radiography devices unconditionally pass the test, 2.1% are in the status of ‘conditional pass’ and 13.1% fail the test. From the evaluation conducted, there is no observable correlation between the age of the modality and the results of the compliance test. Overall, only 9.2% of stationary radiography X-ray compliance test reports have included the AEC test since it is not a mandatory requirement of the national protocol.
Mechanism of simulated lunar dust-induced lung injury in rats based on transcriptomics
Authors: Gu Chen , Sun Yan , Mao Meiqi , Liu Jinguo , Li Xiongyao , Zhang Xiaoping 
Published: December 2023

Abstract
Lunar dust particles are an environmental threat to lunar astronauts, and inhalation of lunar dust can cause lung damage. The current study explored the mechanism of lunar dust simulant (CLDS-i) inducing inflammatory pulmonary injury. Wistar rats were exposed to CLDS-i for 4 h/d and 7d/week for 4 weeks. Pathological results showed that a large number of inflammatory cells gathered and infiltrated in the lung tissues of the simulated lunar dust group, and the alveolar structures were destroyed. Transcriptome analysis confirmed that CLDS-i was mainly involved in the regulation of activation and differentiation of immune inflammatory cells, activated signaling pathways related to inflammatory diseases, and promoted the occurrence and development of inflammatory injury in the lung. Combined with metabolomics analysis, the results of joint analysis of omics were found that the genes Kmo, Kynu, Nos3, Arg1 and Adh7 were involved in the regulation of amino acid metabolism in rat lung tissues, and these genes might be the key targets for the treatment of amino acid metabolic diseases. In addition, the imbalance of amino acid metabolism might be related to the activation of nuclear factor kappaB (NF-κB) signaling pathway. The results of quantitative real-time polymerase chain reaction and Western blot further confirmed that CLDS-i may promote the occurrence and development of lung inflammation and lead to abnormal amino acid metabolism by activating the B cell activation factor (BAFF)/ B cell activation factor receptor (BAFFR)-mediated NF-κB signaling pathway.
Metabolic and Bariatric Surgery Utilization Trends in the United States: Evidence From 2012 to 2021 National Electronic Medical Records Network
Authors: Alsuhibani Abdulrahman , Thompson Jonathan R. , Wigle Patricia R. , Guo Jeff Jianfei , Lin Alex C. , Rao Marepalli B. , Hincapie Ana L. 
Published: December 2023

Background:
Bariatric surgery has evolved over the past 2 decades yet assessing trends of bariatric surgery utilization in the growing eligible population is lacking.

Aim:
This study aimed to update the trends in bariatric surgery utilization, changes in types of procedures performed, and the characteristics of patients who underwent bariatric surgery in the United States, using real-world data.

Method:
This retrospective descriptive observational study was conducted using the TriNetX, a federated electronic medical records network from 2012 to 2021, for adult patients 18 years old or older who had bariatric surgery. Descriptive statistical analysis was conducted to assess patients’ demographics and characteristics. Annual secular trend analyses were conducted for the annual rate of bariatric surgery, and the specific procedural types and proportions of laparoscopic surgeries.

Results:
A steady increase in the number of procedures performed in the United States over the first 6 years of the study, a plateau for the following 2 years, and then a decline in 2020 and 2021 (during the coronavirus disease 2019 pandemic). The annual rate of bariatric surgery was lowest in 2012 at 59.2 and highest in 2018 at 79.6 surgeries per 100,000 adults. During the study period, 96.2% to 98.8% of procedures performed annually were conducted laparoscopically as opposed to the open technique. Beginning in 2012, the Roux-en-Y gastric bypass (RYGB) procedure fell to represent only 17.1% of cases in 2018, along with a sharp decline in the adjustable gastric band (AGB) procedure, replaced by a sharp increase in the sleeve gastrectomy (SG) procedure to represent over 74% of cases in 2018.

Conclusions:
Bariatric surgery utilization in the United States showed a moderate decline in the number of RYGB procedures, which was offset by a substantial increase in the number of SG procedures and a precipitous drop in the annual number of AGB procedures.
Physician Characteristics Associated With Opioid Prescribing After Same-Day Breast Surgery in Ontario, Canada: A Population-Based Cohort Study
Authors: Merchant Shaila J. , Shellenberger Jonas P. , Sawhney Monakshi , La Julie , Brogly Susan B. 
Published: December 2023

Background and Objectives:
Opioid overprescribing in patients undergoing breast surgery is a concern, as evidence suggests that minimal or no opioid is needed to manage pain. We sought to describe characteristics of opioid prescribers and determine associations between prescriber’s characteristics and high opioid prescribing within 7 days of same-day breast surgery.

Methods:
Patients ≥18 years of age who underwent same-day breast surgery in Ontario, Canada from 2012 to 2020 were identified and linked to prescriber data. The primary outcome was current high opioid prescribing defined as >75th percentile of the mean oral morphine equivalents (OME; milligrams). Prescriber characteristics including age, sex, specialty, years in practice, practice setting, and history of high (>75th percentile) opioid prescribing in the previous year were captured. Associations between prescriber characteristics and the primary outcome were estimated in modified Poisson regression models.

Results:
The final cohort contained 56,434 patients, 3469 unique prescribers, and 58,656 prescriptions. Over half (1971/3469; 57%) of prescribers wrote ≥1 prescription that was >75th percentile of mean OME of 180 mg, of which 50% were family practice physicians. Adjusted mean OMEs prescribed varied by specialty with family practice specialties prescribing the highest mean OME (614 ± 38 mg) compared to surgical specialties (general surgery [165 ± 9 mg], plastic surgery [198 ± 10 mg], surgical oncology [154 ± 14 mg]). Whereas 73% of first and 31% of second prescriptions were provided by general surgery physicians, family practice physicians provided 2% of first and 51% of second prescriptions. Prescriber characteristics associated with a higher likelihood of high current opioid prescribing were family practice (risk ratio [RR], 1.56; 95% confidence interval [CI], 1.35–1.79 compared to general surgery), larger community practice setting (RR, 1.34; 95% CI, 1.05–1.71 compared to urban), and a previous high opioid prescribing behavior (RR, 2.28; 95% CI, 2.06–2.52).

Conclusions:
While most studies examine surgeon opioid prescribing, our data suggest that other specialties contribute to opioid overprescribing in surgical patients and identify characteristics of physicians likely to overprescribe.