bluuebunny/crossref_metadata_2025_split huggingface dataset:
High-grade fetal adenocarcinoma of the lung misdiagnosed as male breast carcinoma: a case report and literature review
Authors: Zhuo Yuejian , Xu Yanran , Qin Rong , Guo Min , Zhang Dongdong 
Published: December 2023

Background and aimHigh-grade fetal adenocarcinoma of the lung (HG-FLAC) is a specific subtype of lung adenocarcinoma with a poor prognosis. A lack of understanding exists because of the rarity of this disease. This study aimed to present a case of HG-FLAC with multiple metastases misdiagnosed as male breast carcinoma at the initial diagnosis.Case presentationThe patient visited our hospital due to a month-long cough. The chest computed tomography (CT) scan revealed a mass in the left lung and chest wall, accompanied by enlargement of mediastinal lymph nodes. The magnetic resonance imaging indicated potential metastatic lesions in the brain and adrenal glands. The patient underwent a biopsy of the lesion in the right chest wall. The pathological and immunohistochemical findings indicated a high possibility of male breast cancer. However, the clinical features did not support this diagnosis. Therefore, a CT-guided percutaneous lung biopsy was performed, and the pathological examination finally indicated HG-FLAC.ConclusionsWe presented a complex yet interesting case in which HG-FLAC was misdiagnosed as male breast cancer. Our interesting case may stimulate discussions about the methods to manage patients with HG-FLAC.
Assessment of anticancer properties of cumin seed (Cuminum cyminum) against bone cancer
Authors: Chandrasekaran Rajkuberan , Krishnan Muthukumar , Chacko Sonu , Gawade Omkar , Hasan Sheik , Joseph John , George Evelin , Ali Nemat , AlAsmari Abdullah F. , Patil Sandip , Jiang Haoli 
Published: December 2023

IntroductionEarly-life osteosarcoma is associated with severe morbidity and mortality, particularly affecting young children and adults. The present cancer treatment regimen is exceedingly costly, and medications like ifosfamide, doxorubicin, and cisplatin have unneeded negative effects on the body. With the introduction of hyphenated technology to create medications based on plant molecules, the application of ayurvedic medicine as a new dimension (formulation, active ingredients, and nanoparticles) in the modern period is rapidly growing. The primary source of lead compounds for the development of medications for avariety of ailments is plants and their products. Traditionally, Cuminum cyminum (cumin) has been used as medication to treat a variety of illnesses and conditions.MethodsThe cumin seed was successfully extracted with solvents Hexane, Chloroform, Methanol, Ethanol and Acetone. Following the solvent extraction, the extract residue was assayed in MG63 cells for their anti-proliferative properties. ResultsFirst, we used the [3-(4,5-Dimethylthiazol-2-yl)-2,5-Diphenyltetrazolium Bromide] (MTT) assay to test the extracted residue’s cytotoxicity. The results show that hexane extract Half-maximal inhibitory concentration (IC50 86 µG/mL) effciently inhibits cells by causing programmed cell death. Furthermore, using the Acridine orange/ethidium bromide (AO/EB) staining method, the lactate dehydrogenase assay, and the reactive oxygen species assay using the Dichloro-dihydro-fluorescein diacetate (DCHFDA) staining method, we have demonstrated that the hexane extract causes apoptosis in MG63 cells. Furthermore, flow cytometry research revealed that the hexane extract stops the cell cycle in the S phase. In addition, the hexane extract limits colony formation and the migration potential as shown by the scratch wound healing assay. Furthermore, the extract from cumin seeds exhibits remarkable bactericidal properties against infections that are resistant to drugs. Gas chromatography analysis was used to quantitatively determine the hexane and methanolic extract based on the experimental data. The primary chemical components of the extract are revealed by the study, and these help the malignant cells heal. The present study finds that there is scientific validity in using cumin seeds as a novel method of anticancer therapy after undergoing both intrinsic and extrinsic research.
The effects of upper- vs. lower-body aerobic exercise on perceived pain in individuals with chronic knee pain: a randomised crossover trial
Authors: Deere Rachel , Chowdhury Enhad , Tabor Abby , Thompson Dylan , Bilzon James L. J. 
Published: December 2023

Background and objectivesSome patients with chronic knee pain experience an increase in knee pain following a single bout of exercise involving their knee joint, which can negatively affect exercise adherence and thus result in reduced overall health and lack of disease management. We want to determine whether a single bout of upper-body (UB) aerobic arm-ergometry exercise is effective in reducing the experience of pain in those with chronic knee pain compared with lower-body (LB) aerobic leg ergometry exercise.MethodsA total of 19 individuals (women = 11, men = 8; age = 63 ± 8 years; body mass index = 24 ± 3 kg/m2) who suffered from chronic knee pain for ≥3 months took part in this study. Arm-ergometry and cycle-ergometry exercises were performed for 30 min at a moderate intensity, separated by 7 days. Pain intensity was assessed by means of a visual analogue scale (VAS) pre- and post-exercise and for 7 days post-exercise. Pressure pain threshold (PPT) and mechanical detection threshold (MDT) were measured pre- and post-exercise at both local and distal anatomical sites. Data are presented as mean ± SD.ResultsVAS pain was significantly reduced (p = 0.035) at 1 day post-exercise following the UB exercise trial (−1.4 ± 0.8) when compared with the LB exercise trial (+0.1 ± 2.1). Both UB and LB exercises were effective in reducing local and distal PPT. MDT responses were heterogeneous, and no differences between the UB and LB exercise conditions were noted.ConclusionAn acute bout of upper-body aerobic arm-ergometry exercise evoked a significant decrease in the affected knee joint pain in individuals with chronic knee pain of up to 24 h/1 day post-exercise compared with lower-body aerobic exercise. While the exact mechanisms remain unclear, upper-body exercise may offer a viable, novel therapeutic treatment for patients with chronic knee pain.
“I cannot see your fear!” Altered recognition of fearful facial expressions in anorexia nervosa
Authors: Vaioli Giulia , Bastoni Ilaria , Villa Valentina , Mendolicchio Leonardo , Castelnuovo Gianluca , Mauro Alessandro , Scarpina Federica 
Published: December 2023

BackgroundThe evidence about facial emotion recognition in anorexia nervosa as the role of alexithymic traits on this emotional ability is conflicting and heterogeneous.ObjectiveWe assessed the capability of recognizing facial expressions of two primary emotions, fear, and anger, in the context of anorexia nervosa.MethodsWomen affected by anorexia nervosa were compared with healthy weight women in a well-established implicit facial emotion recognition task. Both reaction time and level of accuracy were computed. Moreover, the individual levels of alexithymia were assessed through a standard self-report questionnaire.ResultsParticipants with anorexia nervosa reported a significantly lower performance in terms of reaction time and accuracy when the emotion of fear—but not anger—was the target. Notably, such an alteration was linked to the levels of alexithymia reported in the self-report questionnaire.ConclusionIn anorexia nervosa, difficulties in processing facial fearful (but not angry) expressions may be observed as linked to higher expressions of alexithymic traits. We suggested future research in which emotional processing will be investigated taking into account the role of the bodily dimensions of emotional awareness.
The influence of demographic and lifestyle factors on blood donation delay among student population: a retrospective study
Authors: Feng Wang , Yun Wang , Le Wang , Zhi-guo Xu , Hai-ying Yang , Shu-fang Wu , Zhen-yan Wei , Yi-zhu Chen , Quan Sun , Jing-xian Fei 
Published: December 2023

ObjectiveThis study analysed blood donation deferral trends, reasons and demographic/lifestyle characteristics among students in Huzhou City. The aim was to understand the health status of students and reduce the deferral rate.MethodsData on blood donation deferral among students in Huzhou City from 2018 to 2022 were collected and analysed. Deferral trends and main reasons were investigated. Using demographic and lifestyle data from 2,619 cases in 2022, a risk prediction model for deferral was constructed.ResultsThe deferral rate among students in Huzhou City from 2018 to 2022 was 12.60% (p = 0.000, 95%CI: 12.14–13.06%), showing a significant increasing trend. Temporary deferral was the main reason, with alanine aminotransferase (ALT), blood pressure (BP) and haemoglobin (Hb) as the main deferral factors. ALT had a deferral rate of 5.23% (4.92–5.53%), BP 3.30% (3.06–3.55%), and Hb 2.92% (2.68–3.15%). Demographic and lifestyle characteristics in 2022 showed no significant differences between education level, household registration and deferral rate (p &gt; 0.05). However, age, sex, blood donation history, sleep quality, diet and mental state had variable effects on ALT, BP, and Hb deferrals (p &lt; 0.05). Logistic regression showed that sex, blood donation history, sleep quality, diet and mental status were independent risk factors for ALT deferral (p &lt; 0.05), with odds ratios (ORs) of 5.057, 2.735, 1.594, 3.679, and 1.957, respectively. Age, blood donation history, sleep quality and mental state were independent risk factors for BP deferral (p &lt; 0.05), with ORs of 0.256, 3.658, 6.042, and 1.812, respectively. Gender, blood donation history and diet were independent risk factors for Hb deferral (p &lt; 0.05), with ORs of 0.244, 0.542, and 3.103, respectively.ConclusionStudents’ health problems require attention. Effective health education should improve self-health management and pre-donation health behaviour to encourage regular blood donation.
Validity of a virtual reality endoscopic retrograde cholangiopancreatography simulator: can it distinguish experts from novices?
Authors: Georgiou Konstantinos , Boyanov Nikola , Antonakis Pantelis , Thanasas Dimitrios , Sandblom Gabriel , Enochsson Lars 
Published: December 2023

BackgroundThere is a lack of evidence regarding the effectiveness of virtual simulators as a means to acquire hands-on exposure to endoscopic retrograde cholangiopancreatography (ERCP). The present study aimed to assess the outcome and construct validity of virtual ERCP when training on the GI II Mentor simulator.MethodsA group of seven experienced endoscopists were compared with 31 novices. After a short introduction, they were requested to carry out three virtual ERCP procedures: diagnosing and removing a common bile duct (CBD) stone; diagnosing and taking brush cytology from a hilar stenosis; and, finally, diagnosing and treating a cystic leakage with a BD stent. For each task, the total time required to complete the task, time required to correctly view the papilla, total time of irradiation, time to deep cannulation, time to define diagnosis, time to complete sphincterotomy, and time to complete the respective intervention were measured. Cannulation of the BD, correct diagnosis, sphincterotomy, and time to complete intervention were assessed by an assessor blinded to the status of the endoscopist who performed the virtual ERCP.ResultsThe time required to visualize the papilla and to cannulate deeply when removing the BD stone was significantly shorter for the experts (both p &lt; 0.05). The time to visualize the papilla, cannulate deeply, reach a diagnosis, complete sphincterotomy, and complete the intervention was significantly shorter for the experts when managing cystic leakage (all p &lt; 0.05). In diagnosing and taking brush cytology from a hilar stenosis, there was only a trend toward the experts needing less time for the deep cannulation of the BD (p = 0.077).ConclusionThe performance differed between experts and novices, especially in the management of cystic leakage. This corroborates the construct validity of the GI II Mentor simulator.
La motorisation du sous-marin français, des origines à 1914
Authors: Brisou Dominique 
Published: December 2023

A little over one hundred years ago submarines progressed from the stage of an invention to that of an innovation. This was thanks to the take-off of a technology that alone could enable them to develop - electricity, the crucial element in the second industrial revolution. But the electric motor alone offered little for this new weapon of war at sea because of the extremely feeble range of its batteries. For safety reasons the internal combustion petrol engine was rejected as a means to recharge the batteries whilst the submarine was surfaced. From 1904 the brand-new diesel engine, powered by a safe heavy fuel, would give the submarine its definitive configuration and endow it with great military potential -major use of which was made in the two main wars of the Twentieth Century.
Until diesel trials were successfully completed, the steam-engine was preferred. The experimental phase was long and painful, proceeding by trial-and-error and with many mistakes. It was the work of three French companies : Sautter-Harlé, the French Otto Gaz Company, both located in Paris, and the French Diesel-Engine Company at Longueville (near Bar-le-Duc),
The completion of this stage of development concerned the four-stroke diesel engine. But around 1910 the German firm M.A.N. came up with a two-stroke variant. Several countries including France adopted this prematurely, for it was far from fully ready. Germany drew on this for a Machiavellian plan aimed at pushing its future enemies onto a disastrous course that would have weakened their submarine forces. This unknown episode is now revealed through exploitation of the archives of the Sautter-Harlé company, deposited in the private collections of the Service Historique de la Marine, cartons 1GG 1-66.
L'administration française du sandjak de Sis/Kozan en 1919-1920
Authors: Zarifian Julien 
Published: December 2023

At the close of the First World War France set up an administration for those regions in the Near-East turned over to her by agreement among the Allies. Thus Cilicia, to the south of present-day Turkey, was placed under the authority of General Dufieux and particularly under Colonel Brémond. Governing this province, with its complex history and ethnic composition, very quickly proved difficult. Besides having few resources at its disposal, the French administration had to retain the existing and generally badly disposed Turko-Ottoman bureaucrats. To tackle this situation, Brémond sent some of his officers to take charge of important Cilician sanjaks (departments).
Thus Captain Taillardat arrived alone at the beginning of 1919 at Sis, the prefecture of the Sanjak of Kozan, at the northern extremity of the French zone. He managed to channel the influx of Armenians, survivors of the genocide of 1915-17, whose return home was favoured French policy and on whose traditionally friendly disposition France counted. Taillardat thoroughly reorganised the Sanjak, beginning with the police. He took steps to improve hygiene, reconstruct houses and roads and improve schooling for children.
The year 1919 closed with a generally positive record for Taillardat’s administration. But soon the Kemalist wave broke over the region, which lost the support of Paris as France opted instead to back the infant Kemalist movement. By the start of June 1920 there were no French left in Kozan. That October the last Armenian town fell. It was the end for French Cilicia, and also for the pluri-secular Armenian presence in the region. In their place came the Republic of Turkey, which would be officially established two years later.
La création trop tardive des divisions cuirassées en 1940
Authors: Chaix Bruno 
Published: December 2023

The French reverses in 1940 were, in part, caused by the dispersion of tanks and the poor performance of armoured divisions, which were created far too late. TTe reasons for these deficiencies are well known but the background to this decision is not well documented. To fill this gap, the author wishes to present an unedited «GQG» paper of December 1939 with his comment.
The administrative attachment of all tanks under infantry in 1920 perpetuated their primary employement as support of the infantry and prevented later initiatives towards the creation of combined armoured units, capable of autonomous operations. TTis was particularly the case in 1932 when «détachements mécaniques de combat» were abandoned under pressure from the Inspector of infantry. In 1936, at the insistance of Daladier, the General Staff, finally, experimented with an armoured division but never decided to field it. Because heavy tanks B - considered essential for armoured divisions - suffered delays in their production and because the French High Command was not convinced of the efficacy of such divisions and favoured infantry support tank battalions. In December 1939, stimulated by Colonel de Gaulle and, above all. General Billotte, the decision to create armoured divisions was taken after a doctrinal debate, perfectly recorded in the «GQG» paper at annex. It was already too late !
Frequency and Nature of Changes in the Skin and Mucous Membranes in Post-COVID-19 Syndrome
Authors: Островский А.М. , Зайцева Е.Д. , Дятлова Д.А. 
Published: December 2023

Цель. Провести анализ клинических случаев изменений кожи и слизистых оболочек после перенесенной новой коронавирусной инфекции. Материалы и методы. В работе представлены результаты изучения частоты и характера изменений кожи и слизистых оболочек при постковидном синдроме у 106 жителей города Гомеля за период с марта по сентябрь 2023 г. Результаты. По результатам исследования была выявлена наибольшая распространенность изменений кожи и слизистых оболочек спустя полгода после тяжелой степени перенесенной новой коронавирусной инфекции у мужчин, статистически значимо увеличивающаяся с возрастом пациентов. Ведущими кожными проявлениями постковидного синдрома у обследованных лиц были сыпь и сухость кожных покровов. Заключение. Оценка накопленных данных позволит определить диагностическую и прогностическую значимость кожной симптоматики у пациентов с постковидным синдромом.
Purpose. To analyze clinical cases of changes in the skin and mucous membranes after COVID-19 infection. Materials and methods. The article presents the results of studying the frequency and nature of changes in the skin and mucous membranes in post-COVID-19 syndrome in 106 residents of the city of Gomel for the period from March to September 2023. Results. According to the results of the study, the greatest prevalence of changes in the skin and mucous membranes was revealed six months after the severe degree of COVID-19 infection in menfolk, statistically significantly increasing with the age of patients. The leading skin manifestations of the post-COVID-19 syndrome in the examined individuals were rash and dryness of the skin. Conclusions. Evaluation of the accumulated data will allow to determine the diagnostic and prognostic significance of skin symptoms in patients with post-COVID-19 syndrome.
Predictive Value of Skin Manifestations in the Development of a Systemic Process in Patients with Lupus Erythematosus
Authors: Ходаковский В.А. , Музыченко А.П. 
Published: December 2023

Цель исследования. Оценить взаимное влияние активности кожных и висцеральных проявлений у пациентов с кожной и системной формами красной волчанки, а также уровень качества жизни. Был проведен ретроспективный анализ 268 историй болезни пациентов, находившихся на стационарном лечении в ревматологическом отделении ГУ «Минский научно-практический центр хирургии, трансплантологии и гематологии» с диагнозом «системная красная волчанка», УЗ «Минский городской клинический центр дерматовенерологии» с диагнозом «красная волчанка». Также проводился клинический осмотр 22 пациентов с одноименными диагнозами. При сравнении кожных проявлений с поражением внутренних органов у пациентов с системной красной волчанкой достоверные различия были выявлены в следующих случаях: 1) развитие эритемы по типу центробежной эритемы Биетта и капилляритов на подушечках пальцев сочеталось с поражением костно-мышечной системы; 2) развитие телеангиэктазий на коже верхних конечностей сочеталось с поражением почек.
The purpose of the study. To evaluate the mutual influence of the activity of cutaneous and visceral manifestations in patients with cutaneous and systemic forms of lupus erythematosus, as well as the level of quality of life. A retrospective analysis of 268 medical records of patients who were hospitalized in the rheumatology department of the State Institution "Minsk Scientific and Practical Center for Surgery, Transplantology and Hematology" with a diagnosis of "systemic lupus erythematosus" was carried out, the Institution "Minsk City Clinical Center of Dermatovenerology" with a diagnosis of lupus erythematosus. A clinical examination of 22 patients with the same diagnoses was also carried out. When comparing skin manifestations with damage to internal organs in patients with systemic lupus erythematosus, significant differences were identified in the following cases: 1) the development of erythema like centrifugal erythema of Biette and capillaritis on the fingertips was combined with damage to the musculoskeletal system; 2) the development of telangiectasia on the upper extremities was combined with kidney damage.
Study of Digital Video Microscopy in the Diagnosis of Non-Scarring Alopecia
Authors: Козин В.М. , Саларев В.В. , Козина Ю.В. , Надирашвили Н.Д. 
Published: December 2023

Введение. Цифровая видеомикроскопия (микроскопия стержня) – это дерматоскопия волосистой части головы, оценка состояния кожи волосистой части головы, роста волос. Цель. Оценить корреляции тяжести течения нерубцовых алопеций на волосистой части головы с результатами анамнеза заболеваний и данными лабораторно-инструментальных исследований гнездной и андрогенетической алопеции. Материалы и методы. На базе амбулаторно-поликлинического отделения УЗ «Витебский областной клинический центр дерматовенерологии и косметологии» за период с 2015 по 2017 г. обследовано 315 пациентов с разными формами алопеции (243 женщины и 72 мужчины) в возрасте от 4 до 68 лет. Результаты. Проведенный анализ anamnesis vitae позволил выявить, что у 87 (27,6%) пациентов в обеих формах алопеции – отягощенный анамнез с наличием клинических проявлений нерубцовых алопеций на момент исследования. Выводы. Цифровая видеомикроскопия без биопсии выявляет диагностические критерии, характерные для нерубцовых алопеций, и позволяет назначить существующее соответствующее лечение гнездной и андрогенной алопеции.
Introduction. Digital video microscopy (rod microscopy) is a dermatoscopy of the scalp, assessing the condition of the scalp skin and hair growth. Purpose. To evaluate the correlations between the severity of non-scarring alopecia on the scalp and the results of the medical history and data from laboratory and instrumental studies of alopecia areata and androgenetic alopecia. Materials and methods. On the basis of the outpatient department of the Vitebsk Regional Clinical Center for Dermatovenereology and Cosmetology for the period from 2015 to 2017 315 patients with different forms of alopecia (243 women and 72 men) aged from 4 to 68 years were examined. Results. The analysis of anamnesis vitae revealed that 87 (27.6%) patients in both forms of alopecia had a burdened medical history with the presence of clinical manifestations of non-scarring alopecia at the time of the study. Conclusions. Digital video microscopy without biopsy reveals diagnostic criteria characteristic of non-scarring alopecia and allows the prescribing of existing appropriate treatment for alopecia areata and androgenetic alopecia.