bluuebunny/crossref_metadata_2025_split huggingface dataset:
The Role of Glutamine Synthetase on the Sensitivity to Radiotherapy of Hepatocellular Carcinoma
Authors: He Yuan , Yu Huihan , Lu Yijun , Zhou Chen , Tian Yu , Song Tianwei , Wang Dandan , Fang Zhiyou , Zhang Zhi , Wang Hongzhi , Qian Junchao 
Published: February 2025

The objective of this study was to investigate the relationship between radiotherapy sensitivity, glutamine synthetase (GS), and oxidative stress (OS) in human hepatocellular carcinoma (HCC) cells. HCC cells were X-ray irradiated, and the effect of glutamine synthetase inhibition on the proliferative capacity of HCC cells was examined using the CCK-8 colony formation assay. Real-time quantitative PCR assays were used to detect the effect of L-methionine sulfoximine (MSO) on cellular glutamine synthetase expression levels and the efficiency of glutamine synthetase knockdown in HepG2 cells. Glutamine synthetase activity assay kit was used to detect the viability of glutamine synthetase in cells and tissues. Oxidative stress production was assayed using an oxidative stress assay kit. Subcutaneous xenografts were used to detect the effects of L-methionine sulfoximine and radiation on tumor growth in vivo. The results showed that the apparent cell proliferation capacity of HCC cells after glutamine synthetase inhibition was significantly reduced after radiotherapy, which was closely related to the increased production of oxidative stress after radiotherapy. Furthermore, the results of animal experiments also showed that the combination of L-methionine sulfoximine and radiation induced a stronger tumor suppressive effect and that L-methionine sulfoximine could act as a radiosensitizer after radiotherapy.
APRESENTAÇÃO
Authors: Trevizam Matheus , Sá Luiz Fernando Ferreira 
Published: February 2025

Literatura e Filosofia / Literatura e Teoria Literária. A partir desses encontros, foi organizada em 2010 a II Jornada em homenagem a Jacques Derrida. O evento debateu leituras, apropriações, transgressões, deslocamentos, contaminações, enxertos e traduções da obra de Jacques Derrida. Embora tenha funcionado como um produtivo espaço de discussão, a II Jornada Jacques Derrida não esgotou, evidentemente, as questões geradas pelo encontro da Literatura, Filosofia e Teoria Literária com o pensamento derridiano. O evento, organizado pelos professores Roberto Said e Luiz Fernando Ferreira Sá, produziu alguns efeitos significativos que estão em parte reunidos neste volume da revista Em Tese, a qual se dedica, parcialmente, a registrar e difundir alguns textos apresentados na referida Jornada.
Fungicides alternatives for pre-flowering linseed
Authors: Bruinsma Gabriel Mathias Weimer , Carvalho Ivan Ricardo , Pradebon Leonardo Cesar , Loro Murilo Vieira , Sarturi Marlon Vinicius da Rosa , Huth Caroline 
Published: February 2025

Molecule rotation in the control of fungal diseases is essential to ensure sustainability and avoid the tolerance of pathogens to fungicides. Evidencing managements that promote greater efficiency in the control can contribute to increase the efficiency in the control of diseases.This work aims to reveal control alternatives for foliar diseases through different anti-fungal molecules applied in pre-flowering in the linseed crop. The experiment took place in the experimental area of Escola Fazenda, UNIJUÍ, located in the municipality of Augusto Pestana (RS). The experimental design used randomized blocks, with ten fungicide treatments in foliar application and three replications, totaling 30 experimental units. In the useful area of ​​each experimental unit, the following characteristics were measured: plant height, plants per square meter, number of grains per plant, weight of grains per plant, grain yield, normalized green red difference index, green leaf index, spectral saturation index. The data obtained were submitted to descriptive analysis and to the assumptions of analysis of variance, such as homogeneity of residual variances by Bartlett's test and normality of errors by Shapiro Wilk. Afterwards, analysis of variance was carried out at 5% probability, with the significant variables, Tukey's test of multiple comparison of means was applied at the level of 5% of probability. In order to identify the tendency of association between the characters, Pearson's linear correlation was determined at 5% probability by t test. The active ingredient Pyraclostrobin + Fluxapyroxad can contribute favorably to the maintenance of floral units, capsules and grains per plant. The correct positioning of the use of the molecule is decisive and requires further studies in linseed culture.
Pericardial Involvement in Hereditary Hemorrhagic Telangiectasia
Authors: Derbel Abir , Snoussi Mouna , Salah Raida Ben , Frikha Faten , Abid Leila , Frikha Imed , Marzouk Sameh , Bahloul Zouhir 
Published: February 2025

Hereditary haemorrhagic telangiectasia is a rare disease characterized by cutaneo-mucous and visceral arteriovenous malformations. Cardiac involvement is uncommon and was presented primarily by hyper-output heart failure. Hemorrhagic pericardial effusion, although is extremely rare, can occur during HHT. We report the case of a 48-years-old woman which was hospitalized in 2015 in internal medicine department, Sfax, Tunisia in 2015 for anicteric cholestasis. She noticed a personnel and familial history of recurrent epistaxis. Biologic findings revealed anemia and moderate cholestasis. Viral investigations and immunologic tests were negative. Abdominal tomography showed multiple arterio-venous shunts of the liver. Liver involvement due to Rendu Osler Weber disease was retained. She was treated by ferrous iron, but she was lost to follow up. She was presented in February 2021, with severe anemia (5 g/dL). Physical examination revealed signs of global heart failure. Biological investigations found anemia, inflammatory biological syndrome, cytolysis and cholestasis. Heart ultrasound revealed an abundant pericardial effusion. Only 500cc of hemorrhagic fluid could be aspirated before the needle became blocked. Unfortunately, one week after, re-accumulation of pericardial fluid and worsening occurred. She underwent a partial surgical pericardial excision with pleuropericardial opening. Analysis of the fluid ruled out any infectious cause of this effusion. Histological examination confirmed the vascular dysplasia with signs of hemorrhage and inflammation. The patient was discharged 1 month after surgery with no other bleeding episodes. For her anemia, she received a transfusion of red blood cells. Then, the patient was treated by iron treatment.
Deficiência, interseccionalidade e suas inflexões teóricas: outras perspectivas para a pesquisa educacional e desafios à educação inclusiva
Authors: Pagni Pedro Angelo 
Published: February 2025

Este artigo analisa os limites e discute as possibilidades de a ferramenta analítica da interseccionalidade e de teorias queer e CRIP minimizarem os efeitos éticos da “indignidade de falar pelo outro”, presentes tanto em parte das pesquisas sobre a deficiência quanto na elaboração das políticas públicas e na efetuação da educação inclusiva. Com tal análise, discussão e circunscrição a essas referências teóricas, objetiva-se ampliar a compreensão sobre a deficiência corrente na apropriação de seu modelo social pelas pesquisas educacionais e situá-la junto a outros marcadores sociais das diferenças, considerando sua singularidade e os desafios que esse outro olhar traz para a educação inclusiva. Para tanto, será problematizado o referido modelo, a partir dos efeitos éticos enunciados pelos filósofos da diferença e, mediante as variações do desenvolvimento da analítica do poder da ferramenta analítica e das teorias circunscritas, serão discutidos os seus limites e possibilidades para o alcance dos objetivos propostos. Pretende-se assinalar, com isso, a radicalidade da interseccionalidade e das teorias que a interseccionaram, a fim de fazer ouvir a voz desse outro, indicando um dos caminhos possíveis, quer para as pesquisas sobre o tema, quer para a educação inclusiva.
Does conservative or arthroscopic management of canine medial coronoid disease lead to improved outcomes?
Authors: Banerjee Anant Andy 
Published: February 2025

Question
In dogs diagnosed with medial coronoid disease, does arthroscopic surgical intervention, compared with conservative management, result in improved mobility and reduced pain?

Clinical bottom line
Category of research:
Treatment.
Number and type of study designs reviewed:
Three studies were identified directly addressing the PICO question. One paper was a retrospective cohort study, another study was a prospective randomised control trial, and the third was a non-randomised non-blinded observational study.
Strength of evidence:
Weak.
Outcomes reported:
The first study was a prospective non-randomised study that did not identify a difference in gait evaluation at the 52 week recheck in dogs treated conservatively compared to those treated arthroscopically, with lameness exacerbated in the arthroscopic treatment group until the 26 week recheck. The second study, a retrospective non-randomised cohort study, showed greater, but not statistically different, owner-reported clinical metrology scores in dogs treated arthroscopically compared to those treated conservatively. Liverpool Osteoarthritis in Dogs (LOAD) and Pain Severity Scores (PSS) were higher but not statistically significant, yet Pain Interference Scores (PIS) were statistically significantly higher at 52 weeks in arthroscopically treated dogs compared to conservatively treated dogs. Age at diagnosis and at time of questionnaire completion were statistically significant for LOAD, PSS, and PIS, with older dogs having higher scores. The third study performed a non-blinded observational study assessing canine patients with bilateral medial coronoid disease, with unilateral arthroscopic subtotal coronoidectomy performed on the most clinically affected limb. Radiographs and computed tomography (CT) imaging were performed at diagnosis, with radiographs taken at follow-up. At the time of follow-up, arthroscopically treated limbs had a higher radiographic score than those treated conservatively, although a significant improvement in lameness was seen at the walk in arthroscopically treated limbs. Conservatively managed dogs showed an unchanged (non-significant) gait. Radiographic changes did not appear to correlate to severity of clinical signs.
Conclusion:
The quality of the published evidence available to answer the PICO question is weak, due to the design of the three reviewed studies. Low patient populations in these three studies also hinder the statistical power of any recommendations made. None of the three studies assesses the complex nature of medial coronoid disease to clearly answer the question posed. The decision to recommend arthroscopy over conservative management therefore depends on the judgement and experience of the veterinary surgeon attending the case. Additionally, assessment of the imaging findings is important when discussing prospective treatment options.
Botulinum toxin type A in the treatment of laryngeal dystonia: a single-center experience
Authors: Ziarno Remigiusz , Dec-Ćwiek Małgorzata , Sobuś Magdalena , Skórkiewicz Konrad , Grudzień-Ziarno Aleksandra , Składzień Jacek , Tomik Jerzy 
Published: February 2025

Aim. The aim of this study was the analysis of the problem of laryngeal dystonia in patients of Otolaryngology and Neurology Clinics to assess the efficiency of effects of Botulin Toxin type A (BOTOXtm) injections on voice quality and function of vocal cords with the use of videolaryngostroboscopic and laryngographic examinations, GRBAS (G - grade of hoarseness, R - roughness, B - breathiness, A – aesthenia, S -strain) scale and voice field.
Material and methods. Between 2020 and 2022 a total of 50 patients with laryngeal dystonia were examined. The videolaryngostroboscopic and laryngographic examinations confirmed laryngeal dystonia. Afterwards the patients undertook Botulinum Toxin type A injections into the thyro-arythenoid muscle.
Results. Control examinations confirmed the improvement of vocal folds movability and the decrease in number of irregular vocal folds vibrations. The next injection of BOTOXtm substance was done 3-6 months after the last injection.
Conclusion. The results of our study suggest that although BOTOXtm toxin still remains the main form of treatment for laryngeal dystonia, using it improves phonatory function of larynx (as proven by videolaryngostroboscopic examination).
Pengaruh Kombinasi Pakan Komersial Dengan Cacing Sutra (Tubifex sp) Terhadap Pertumbuhan Berat Mutlak Ikan Gurame (Osphronemus gouramy L)
Authors: Wibowo Pandu , Hayati Nurul , Wirawan Indra , Agustini Maria 
Published: February 2025

Penelitian ini bertujuan untuk mengetahui pengaruh kombinasi pakan komersial dengan cacing sutra (Tubifex sp) terhadap pertumbuhan bobot absolut ikan gurami (Osphronemus gouramy L). Metode dalam penelitian ini menggunakan metode eksperimen dengan pengumpulan data yang dilakukan secara obstruktif secara langsung. Desain eksperimen yang digunakan dalam penelitian ini berupaRancangan Acak Lengkap (RAL) dengan 5 kombinasi pakan pellet dan ulat sutera yang berbeda, yaitu: Perlakuan (A) Pakan komersial (Pellet) 100%.; Perawatan (B) Pakan komersial (Pelet) 75% + 25% ulat sutera; Perawatan (C) Pakan komersial (Pelet) 50% + 50% ulat sutera; Pengobatan (D) Pakan komersial (Pelet) 25% + 75% ulat sutera; Pengobatan (E) ulat sutera 100%. Hasil penelitian yang memberikan nilai terbaik bagi pertumbuhan berat ikan mas (Osphronemus gouramy L). dalam perlakuan (D) pakan komersial (Pelet) 25% + 75%) dari 2gram. Hasil penelitian pengamatan kualitas air menunjukkan bahwa keseluruhan masih pada kadar optimal untuk mendukung kelangsungan hidup ikan mas (Osphronemus gouramy) dengan suhu 27 – 29 ºC. pH 7,1 – 7,5. Oksigen terlarut 5,3 - 5,7 ppm. Kata kunci: berat mutlak, ikan gurami, kombinasi, pakan
Novel Polymer Development Creates New High-Temperature, High-Pressure Cement Slurry Suspending Agent
Authors: Wang Chengwen , Song Lifang , Liu Jingping , Wang Chengli , Wang Hongtao , Xue Zedong , Shi Aipu 
Published: February 2025

Summary
A high-temperature suspending agent with temperature resistance up to 200°C has been developed to address the challenges of high-temperature, high-density cement slurry (2.0–2.6g/cm3) settling and destabilization during cementing in deep wells (4500–6000 m) and ultradeep wells (&gt;6000 m). This suspending agent is designed to introduce modified nano-silica (nano-SiO2) and long hydrophobic side-chain temperature-sensitive monomers. The inclusion of modified nano-SiO2 enhances the temperature resistance of the suspending agent and improves the suspension stability of solid-phase particles in high-density cement slurries. Concurrently, the long hydrophobic side chains increase the viscosity of the cement slurry at high temperatures through hydrophobic bonding. The synergistic effect of these components can delay settling of high-density cement slurries at high temperatures. In performance evaluations adhering to American Petroleum Institute (API) standards, the addition of 0.6 wt% of the suspending agent to a high-density cement slurry (density of 2.35 g/cm³) reduced the density difference between the top and bottom of the slurry from 0.897 g/cm³ to 0.028 g/cm³ after curing at 200°C, surpassing the local (Chinese) standard requirement of 0.05 g/cm³. This contributes to maintaining the overall uniformity of solid-phase particles in high-density cement slurry at high temperatures. It ensures the proper development of slurry consistency and cement strength properties. This advancement can help to reduce the risks associated with deep well cementing, supporting the quality of cementing operations in deep and ultradeep wells, and holds promise for starting some field tests.
Diversified farming and agroecology: Assessing cacao and coffee smallholders’ food security, dietary diversity, and vulnerability to hurricanes and other hazards in Central America
Authors: Bacon Christopher , Sundstrom William A 
Published: February 2025

Abstract

Diversified farming is one of several agroecological strategies for reducing smallholders’ risk and building resilience to climate change and other hazards. Accumulating evidence shows that farmers can use agroecology to improve household food security and influence food system transformations. However, additional research is needed to identify which agroecological strategies are used by whom and the degree to which diversification, household characteristics, context, or other strategies contribute to farmer well-being. In 2022, we conducted a livelihood, agriculture, and food security survey with 429 smallholders sampled randomly from farmers affiliated with cooperatives selling coffee or cacao in northern Nicaragua. We focus on farmer strategies and practices associated with 9 key agroecology principles and their relation to food security, water security, and dietary diversity. Next, we integrated statistical analysis into our participatory mixed methods approach using partner feedback and 13 farmer interviews to inform and interpret regression models. Cacao farmers in the wetter growing zone reported more crop diversity, organic production, and less seasonal hunger than coffee growers. Food and input price inflation was a more pressing concern than impacts from hurricanes Eta and Iota for all producers. Our multivariate analysis suggested that location was less important than surplus subsistence (corn and bean) production, water security, farm size, and income, all correlated significantly with improved seasonal hunger. Production diversity and farmers’ formal education correlated with household dietary diversity. This is among the first studies comparing coffee and cacao producers and assessing their agroecological strategies in relation to food security, water security, nutrition, and vulnerability. Findings are relevant for many of the 15 million smallholder coffee and cacao growers seeking more sustainable livelihoods and for potentially modifying the useful multidimensional agroecological indicators frameworks, like the UN FAO’s Tool for Agroecological Performance Assessment, to include measures of farmers’ water and food security.
Consequential Differences in Satellite-Era Sea Surface Temperature Trends Across Datasets
Authors: Menemenlis Sofia , Vecchi Gabriel , Yang Wenchang , Fueglistaler Stephan , Raghuraman Shiv Priyam 
Published: February 2025

Abstract

Global surface temperatures since the 1980s, when near-global satellite-based sea surface temperature (SST) measurements became available, are presumed to be well-known. Satellite-era warming trends in four commonly used global (land+ocean) temperature reconstructions agree closely. However, trends in four commonly used SST datasets show first-order differences, with 1982-2022 60°S to 60°N trends ranging from 0.09-0.17 °C per decade. These large discrepancies are perplexing given the agreement between global temperature datasets and the fact that 70% of Earth’s surface is covered by ocean, but are legible upon recognizing that global temperature datasets use SST fields whose trends agree more closely than those of the above four SST datasets. Considering the trend uncertainty across SST datasets widens the range of plausible global temperature trends and impacts interpretations of recent record global temperatures. We discuss some of these findings’ wide implications for understanding the character and impacts of global warming.
A 2-Years Comparative Analysis of Tirzepatide, Semaglutide, Qsymia, Contrave, and Phentermine on Ocular Health in Individuals with Obesity: A Propensity-Score Matched Cohort Study
Authors: Su Pen-Hua , Huang Yu-Nan , Chen Jo-Ching , Li Pin-Hung , Hsu Min-Yen , Cheng Chun-Wen , Meyerowitz-Katz Gideon 
Published: February 2025

Abstract

This landmark propensity-score matched study examined ocular outcomes of modern anti-obesity medications in nearly 5 million non-diabetic individuals with obesity. Through analysis of TriNetX US network data, we discovered that Tirzepatide significantly reduced cataract risk versus other treatments, showing a striking 59% lower risk compared to Semaglutide (HR: 0.41, 95% CI: 0.19–0.85). Semaglutide users experienced markedly fewer visual disturbances than those on Contrave (HR: 0.58, 95% CI: 0.41–0.82) or Phentermine (HR: 0.62, 95% CI: 0.46–0.82). Both GLP-1 receptor agonists demonstrated protection against age-related cataracts, with Tirzepatide showing exceptional benefits versus Contrave (HR: 0.17, 95% CI: 0.07–0.42). While these protective effects remained robust across patient subgroups, Tirzepatide's benefits diminished in those with impaired kidney function. Multiple sensitivity analyses and negative controls validated these compelling findings.
Predicting Intentions to Use Non-Alcoholic Drinks: Applying the Theory of Planned Behaviour (TPB)
Authors: Adams Sherifdeen 
Published: February 2025

Abstract

Introduction: Non-alcoholic drinks brands such as; sodas, juices, beers, gins, wines, stouts, Heinekens, lagers, spirits, sparkling ciders, and pale ales, etc. are the fastest growing area in the industry, and investment has meant the quality of such drinks is improving rapidly. The demand for these beverages is complex and changes over time with the introduction of new brands. However, little is known about consumers’ intention to use these drinks, and very little social research has explored this to date. Recent developments in non-alcoholic drinks markets have heightened the need for research on consumers’ intention to use non-alcoholic drinks and how different attributes influence these behaviours. This study sought to predict consumers’ intention to use non-alcoholic drinks based on the Theory of Planned Behavior (TPB).
Methods: The study adopted a cross-sectional design comprising a quantitative method. Ajzen’s Theory of Planned Behavior is used as a theoretical framework and postulates three components: attitude, subjective norms, and perceived behaviour control. Data were collected online from 200 participants using a self-administered questionnaire. The participants were between 18 and 50 years old and residing in the United Kingdom. Results were presented in frequencies, percentages, means, and standard deviation. The multiple regression model was used to predict whether independent variables are associated with the dependent variable.
Results: The findings of this study demonstrate that subjective norms predominantly influence the intention to use non-alcoholic drinks. Hence subjective norms (p<.001) had a significant association with intention. The other covariates were not statistically significant.
Conclusion: This study's practical implications contribute knowledge to investors, industries, and manufacturers in expanding their market and to governmental organizations in stimulating non-alcoholic consumption in the country.