bluuebunny/crossref_metadata_2025_split huggingface dataset:
Use and Cost of Healthcare Services Among Patients with Moderate-to-Severe Osteoarthritis of Hip/Knee with Inadequate Analgesia: Findings from two United States Health Systems
Authors: Lu Yi , Ganz Michael L , Robinson Rebecca L , Zagar Anthony J , Huse Samuel , Hartrick Craig T , Johnston Beth , Dorling Patricia , Thakkar Sheena , Berger Ariel 
Published: October 2023

Abstract
Background
Accurate estimates of costs specific to persons with moderate-to-severe hip and/or knee osteoarthritis who experience inadequate analgesia are difficult to obtain, and are likely to be substantial. To address this issue, this study compared use and cost of healthcare services among patients with moderate-to-severe hip/knee osteoarthritis and inadequate response to ≥ two pain-related medications (“cases”) vs. other patients with hip/knee osteoarthritis (“comparators”).
Methods
This retrospective cohort study used healthcare claims data obtained from two integrated delivery networks: Henry Ford Health and Reliant Medical Group. Patients with hip/knee osteoarthritis, aged ≥ 18 years as of their first hip/knee osteoarthritis diagnosis, and with no evidence of malignancy at any time during the study period (2014–2018) were identified. Patients were stratified into cases and comparators using a previously developed machine-learning algorithm. Inverse probability weights were used to balance the distribution of baseline characteristics between cases and comparators. Use and cost of osteoarthritis-related and all-cause healthcare services were assessed.
Results
The sample included 12,801 (84.7%) cases and 2,318 (15.3%) comparators. Except for emergency department visits and osteoarthritis-related pharmacotherapies, weighted rates of other types of healthcare services use were higher for cases, especially osteoarthritis-related hospitalizations (36.4 vs. 9.6 per 100 patient-years) and non-physician visits (103.8 vs. 45.8 per 100 patient-years). Mean adjusted 12-month cumulative costs for both osteoarthritis-related and all-cause healthcare services were substantially higher for cases than comparators ($7,477 vs. $1,606, p < 0.01 and $16,950 vs. $11,113, p = 0.02, respectively).
Conclusions
Use of a previously validated machine-learning algorithm improves the ability to identify cases, without the need for chart review or primary data collection. Case patients used more healthcare services and incurred higher healthcare costs than other patients with hip/knee osteoarthritis, with the difference in cumulative adjusted total costs of OA-specific healthcare services increased over the follow-up period. These findings illustrate the importance of understanding and estimating the economic burden and unmet needs of more severe forms of hip/knee osteoarthritis. Our study highlights the need of considering both disease severity and treatment response profiles when treating OA.
In vivo reactive astrocyte imaging using [18F]SMBT-1 in tauopathy and familial Alzheimer’s disease mouse models - a multitracer study
Authors: Kong Yanyan , Xie Fang , Wang Xiuzhe , Zuo Chuantao , Huang Qi , Shi Kuangyu , Rominger Axel , Xiao Jianfei , Li Ming , Wu Ping , Yang Yunhao , Guan Yihui , Ni Ruiqing 
Published: October 2023

Abstract

Background:
Reactive astrocytes play important roles in the development of Alzheimer’s disease (AD) and primary tauopathies. Here, we aim to investigate the relationship between reactive astrocytes, tau and amyloid beta, microgliosis and glucose metabolism by using multitracer imaging in widely used tauopathy and familial AD mouse models.
Results:
Positron emission tomography (PET) imaging using [18F]SMBT-1 (monoamine oxidase-B), [18F]florbetapir (amyloid-beta), [18F]PM-PBB3 (tau), [18F]DPA-714 (translocator protein) and [18F]fluorodeoxyglucose (FDG) was carried out in 3- and 7-month-old rTg4510 tau mice, 5×FAD familial AD mice and aged-matched wild-type mice. We found increased regional [18F]SMBT-1, [18F]DPA-714 uptake, and hypoglucose metabolism in the brains of 7-month-old rTg4510 mice with tau accumulation as well as in 7-month-old 5×FAD mice with higher amyloid-beta and tau accumulation compared to age-matched wild-type mice.
Conclusion:
In summary, these findings provide in-vivo evidence for reactive astrocytes, microglial activation, and cerebral hypoglucose metabolism in animal models of tauopathy and familial AD.
Measurement of diaminoxidase (DAO) during low-histamine or ordinary diet in patients with and without histamine intolerance
Authors: odijk Jenny van , Weisheit Adina , Ekerljung Linda , Rentzos Georgios 
Published: October 2023

Abstract
Quantification of diamine oxidase (DAO) concentrations within the serum has been proposed as an adjunctive diagnostic modality for the evaluation of histamine intolerance (HIT). Limited empirical data exist concerning the influence of dietary patterns on DAO levels. In the context of a prospective study employing a crossover design, 18 individuals diagnosed with HIT were randomized to initiate either a low histamine diet (LHD) or a conventional mixed diet (MXD). Serum DAO concentrations were measured at the commencement of the study and following each dietary phase. A control group underwent analogous DAO assessments without imposition of dietary constraints. Throughout the period of histamine-restricted dietary intervention, discernible distinctions in alterations of DAO levels failed to manifest in comparison to alterations observed during the MXD phase. Specifically, among the cohort, 10 of the 18 patients exhibited elevated DAO values subsequent to the LHD regimen, while the remaining eight displayed either reduced or unchanging DAO levels. The prevalence of elevated DAO levels in the LHD group did not differ significantly from that observed in the control group during the MXD phase. Additionally, during the LHD phase, patients reported a significant reduction in gastrointestinal and cutaneous symptoms. This prospective investigation underscores the enduring utility of a histamine-restricted diet, coupled with structured dietary reintroduction, as an efficacious diagnostic approach for individuals presenting with suspected food-related histamine hypersensitivity. Notably, measurement of DAO levels appears to furnish only a limited capacity to discern dietary-induced fluctuations. Notwithstanding, the dynamics of DAO alteration do not appear to exhibit a discernible association with specific dietary patterns, a finding consistent across both patient and control groups.
Meta-analysis of the effects of carbon nanoparticles on parathyroid glands during thyroid papillary carcinoma surgery
Authors: wu xiaoyong , zhang jiayi , yan xuemin , Wang yuexin , wen jinxu 
Published: October 2023

Abstract

Backgroud：carbon nanoparticles suspension injection is a commonly used lymph node tracer in thyroid tumor surgery. Its effect on the parathyroid gland is still unclear. Therefore, this paper attempted to evaluate the effect of the application of carbon nanoparticles in thyroid cancer surgery on the parathyroid gland by meta-analysis.
Method：Literature retrieved from the Cochrane Library, Embase, PubMed, Sinomed, CNKI and Wanfang databases was reviewed. Retrieved December 1, 2022. The outcome measures included as effective measures were relative risk (RR) and 95% confidence interval (CI). For data analysis, Stata 15.0 software is employed.
Results: A total of 14 studies were included in this meta-analysis. 1117 patients with papillary carcinoma of thyroid were treated with carbon nanoparticles during surgery, and 997 patients were treated with conventional surgery without carbon nanoparticles. The results showed that compared with conventional surgery, the application of nano carbon can reduce the parathyroid gland misincision and reduce the incidence of postoperative hypocalcemia. (RR=0.42,95%CI 0.35-0.5,P < 0.00001).
Conclusions: The use of carbon nanoparticles in the treatment of thyroid papillary carcinoma is advantageous for parathyroid gland protection.
Tannase enzyme (Tannin acyl hydrolase, EC 3.1.1.20 : Source of Gallic acid and various Gallate biproducts) production by Solid state fermentation With Aspergillus niger from fruit and tea wastes and optimization of the process parameters by OVAT and Response Surface Methodology
Authors: Das Sayan , Ghosh Uma , Biswas Prasanta Kr. 
Published: October 2023

Abstract

Biocatalysts are amongst the valuable articles required for urgent need of people and are produced by microbial sources. In general enzymes are manufactured by submerged fermentation. However it is expensive because of its high operating costs. Solid state fermentation (SSF) is a propitious alternative for manufacture of enzyme in a cost effective way. Development of food products with fruits and vegetables propagate peels in enormous quantity as waste.Bioconversion of the waste for enzyme synthesis results several advantages including value addition to the waste, reduction in environmental pollution, simultaneously reducing the production cost of enzyme. The diverse administration of Tannase in food and feed processing, chemical as well as waste treatment makes it one of the most potential enzymes for Industry. The present study reveals the biosynthesis of Tannase enzyme from food wastes such as peels of fruits and vegetables, used tea leaves and wheat bran by SSF applyingAspergillus nigerstrain. As a result of this work Orange peel was found as potential substrate to Tannase producer resulting highest amount of enzyme 0.0037 unit/gm dry solid followed by mango peel and used tea leaves with activity of 0.0035 and 0.0026 u/gds respectively. The ideal condition of fermentation studied by OVAT methodology and highest activity 0.0038 u/gds was observed at 300C temperature, for 9 days of fermentation under static condition by orange peel with hydration of 1:3 w/v. Finally RSM (Response surface methodology) was applied for optimization of parameters to improve tannase yield.
Establish a novel tumor budding-related signature to predict prognosis and guide clinical therapy in colorectal cancer
Authors: Li Qixin , Liu Gaixia , Qiu Quanpeng , Zhang Jiaqi , Li Ruizhe , Zhao Jiamian , She Junjun , Chen Yinnan 
Published: October 2023

Abstract
Tumor budding is a long-established independent adverse prognostic marker for colorectal cancer (CRC), yet assessment of tumor budding was not reproducible. Therefore, development of precise diagnostic approaches to tumor budding is in demand. In this study, we first performed bioinformatic analysis in our single-center CRC patients’ cohort (n = 84) and identified tumor budding-associated hub genes using the weighted gene co-expression network analysis (WGCNA). A machine learning methodology was used to identify hub genes and construct a prognostic signature. Nomogram model was used to identified hub genes score for tumor budding, and the receiver operating characteristic (ROC) curve and calibration plot indicated high accuracy and stability of hub gene score for predicted the prognosis of CRC. The association between budding-associated hub genes and score and prognosis of CRC were further verified in TCGA CRC cohort (n = 342). Then gene set enrichment analysis (GSEA) and gene set variation analysis (GSVA) were applied to explore the signaling pathways related to the tumor budding and validated by immunohistochemistry (IHC) of our clinical samples. Subsequently, immune infiltration analysis demonstrated that there was a high correlation between hub genes score and Macrophages M2 cells infiltrated in tumor tissue. In addition, somatic mutation and chemotherapeutic response prediction were analyzed based on the risk signature. In summary, we established a tumor budding diagnostic molecular model, which can improve tumor budding assessment and provides a promising novel molecular marker for immunotherapy and prognosis of CRC.
Secondary implant stabilization using a modified microplate fixation technique.
Authors: Helal Mohamed Hamdy , Aboushelib Moustafa Nabil 
Published: October 2023

Abstract
Objectives: to enhance initial stability of dental implants placed in compromised bone defects with poor initial stability using a modified fixation technique.
Methods: Two osteotomy defects (6 mm and 4 mm in diameter) were made in the femur of a dog model. Dental implants (4 mm in diameter and 10 mm in length) were placed in the two defects. Microplates were used to enhance the initial stability of the compromised implant placed in the larger defect size without the need for the additional use of a bone graft. A reverse torque test and histomorphometric analysis were performed after eight weeks to assess bone implant contact (n=48).
Results: Both plate and control implants had almost identical bone-to-implant contact ratios, 82.55 ± 0.61 and 82.86 ± 0.69, respectively. The two tested implants had no statistically significant difference in bone implant contact (t=1.155, p=.260) nor reverse torque test (t=1.408, p=.173).
Conclusions: Secondary implant stabilization improved osteointegration of implants suffering from poor initial stability without the need to resort to bone graft or other complicated techniques.
Rope Skipping or Badminton? The Effect of Exercise on Sleep Quality and Fatigue in University Students
Authors: Ye Zixin , Tan Shuyue , Zhu Yingyuan , Fan Jialin 
Published: October 2023

Abstract
Background
Fatigue and poor sleep quality are common among university students and can negatively affect their studies, college lives, and physical and mental health. Aerobic exercise has shown promise in mitigating these issues. However, exercise interventions involved in previous studies were often time-consuming. To identify a more efficient approach, we evaluated the effects of 15-day rope skipping and badminton interventions on fatigue and sleep issues. We hypothesized that both badminton and rope skipping would be effective in mitigating fatigue and sleep problems and that the effect of rope skipping would be greater than that of badminton.
Methods
Seventy-six participants’ levels of fatigue and sleep were assessed via five variables, using the Consensus Sleep Diary, the Pittsburg Sleep Quality Index, and the fatigue diary.
Results
Both exercises were effective only in improving perceived fatigue and sleep onset latency. One of the reasons for the nonsignificant results could be that some participants’ sleep was disturbed by roommates sharing the same bedroom.
Conclusions
Short-term rope skipping and badminton can effectively improve the fatigue and sleep quality of university students. In addition, we found that some participants reported being more interested in exercise after the intervention, suggesting that exercise interventions could be used to foster exercise habits.
Differential efficacy of screening modalities for colorectal neoplasms: a systematic review and network meta-analysis of randomized controlled trials
Authors: Ashraf Muhammad Talal , Sohail Affan , Khan Muhammad Khuzzaim Shakeel , Khalid Muhammad Hamza Awais , Aslam Muaaz , Uddin Naseer , Khan Anosh Aslam , Ochani Rohan Kumar , Surani Salim 
Published: October 2023

Abstract
Introduction:
Colorectal cancer (CRC), being a major global health problem and the second most common cancer, leads to more than 550,000 deaths per year globally. CRC usually arises from precancerous growths called adenomas. The investigations, flexible sigmoidoscopy (FS), and colonoscopy can help in detecting high-risk precancerous growths and malignant tumors. Most invasive and high-risk colorectal tumors cause occult bleeding, which can be detected by fecal immunochemical test (FIT) and guaiac fecal occult blood test (gFOBT). All these methods can be used to detect malignancies and benign colorectal tumors in patients at risk of developing cancer. This network meta-analysis aims to compare the effectiveness of gFOBT, FIT, FS and colonoscopy for the early detection of CRC.
Methods: Search was conducted for all randomized controlled trials (RCTs) in relevant databases (1975-2022), assessed the risk of bias, and retrieved data from relevant RCTs. The participants either underwent screening through the above-mentioned techniques or received no screening at all. Participants who did not undergo any screening were tested as a common control for all screening interventions. Primary outcomes were the incidence of CRC, the incidence of high-risk adenoma, all-cause mortality, and CRC-related mortality. Odds ratio (OR) and 95% CI estimates were calculated using the method of Bayesian network meta-analysis.
Results: We identified 11 RCTs involving over one million participants. The reported mean age was 61.87 (45-80) years, and the overall gender distribution was balanced between all the comparison arms. The overall mean prospective follow-up was 8.05 (5.5-11) years after the initial screening was performed. FS offered the greatest reduction in CRC findings [OR = 0.733, 95% CI (0.666, 0.807)] when compared to no screening group. Colonoscopy was associated with a higher detection of CRC as the group had an increased number of high-risk patients [OR = 2.28; 95% CI (1.95, 2.67)]. Biennial FIT is associated with the lowest risk of high-risk adenoma detection [OR = 0.293; 95% CI (0.259,0.330)]. Annual gFOBT is associated with the greatest reduction in the risk of CRC-related mortality [OR 0.757; 95% CI (0.584, 0.977)]. FS is associated with the greatest reduction in the risk of all-cause mortality compared to the no-screening group [OR 0.801; 95% CI (0.772, 0.832)].
Conclusion: Colonoscopy is the most effective screening technique in detecting the incidence of CRC and as well as the incidence of CRC-related mortality. Biennial gFOBT is the most effective non-invasive test and significantly detects the greatest risk of high-risk adenoma development. Sigmoidoscopy is associated with the lowest risk of an all-cause mortality.
Non-COVID-19 deaths in Norway 2020–2022. A population-based cross-sectional register study
Authors: Raknes Guttorm , Fagerås Stephanie Jebsen , Sveen Kari Anne , Júlíusson Pétur Benedikt , Strøm Marianne Sørlie 
Published: October 2023

Abstract
Background
Causes of death other than COVID-19 seem to contribute significantly to the excess mortality observed during the 2020–2022 pandemic. In this study, we explore changes in non-COVID-19 causes of death in Norway during the COVID-19 pandemic from March 2020 to December 2022.
Methods
We performed a population-based cross-sectional study on data from the Norwegian Cause of Death Registry. All recorded deaths from 1st January 2010 to 31st December 2022 were included. The main outcome measures were the number of deaths and age-standardised death rate (ASMR) per 100000 population from the major cause of death groups in 2020, 2021 and 2022. The predicted number of deaths and ASMRs were forecasted with a 95% prediction interval constructed from a general linear regression model based on the corresponding number of deaths and rates from the preceding ten prepandemic years (2010–2019). We also examined whether there were deviations from expected seasonality in the pandemic period based on prepandemic monthly data from 2010–2019. The cumulative number of deaths and ASMR were estimated based on monthly mortality data.
Results
There was significant excess mortality (number of deaths) in 2021 and 2022 for all causes (3.7% and 14.5%), for cardiovascular diseases (14.3% and 22.0%), and for malignant tumours in 2022 (3.5%). In terms of ASMR, there was excess mortality in 2021 and 2022 for all causes (2.9% and 13.7%), and for cardiovascular diseases (16.0% and 25,8%). ASMR was higher than predicted in 2022 for malignant tumours (2.3%). There were fewer deaths than predicted from respiratory diseases (except COVID-19) in 2020 and 2021, and from dementia in 2021 and 2022. From March 2020 to December 2022, there were cumulatively 3754 (ASMR 83.8) more non-COVID-19 deaths than predicted, of which 3453 (ASMR: 79.6) were excess deaths from cardiovascular disease, 509 (ASMR 4.0) from malignant tumours. Mortality was lower than predicted for respiratory diseases (-1889 (ASMR: -44.3)), and dementia (-530 (ASMR − 18.5)).
Conclusions
There was considerable excess non-COVID-19 mortality in Norway from March 2020 until December 2022, mainly due to excess cardiovascular deaths. For respiratory diseases and dementia, mortality was lower than predicted.
Early Experiences of Low- and Middle-Income Countries with Integration of COVID-19 Vaccination into Health Systems and Routine Health Services
Authors: Belayneh Asalif , Curry Dora Ward , Edwards Amanda , Gallo Kerry , Maguiraga Fodie Fodie , Mounts Anthony , Tupps Cara 
Published: October 2023

Abstract

Background
Vertical and fragmented tactics used in the global introduction of COVID-19 vaccination strained health systems in low- and middle-income countries (LMIC). Global strategy has shifted from achieving short-term coverage goals towards sustainable integration of COVID-19 vaccination into health systems. The COVID-19 Vaccine Implementation Program (CoVIP) examined early experiences of LMIC with COVID-19 vaccine integration, gaining insights to inform policy, decision-making, and financing.
Methods
COVIP surveyed 24 countries to assess COVID-19 vaccination integration occurring between March 2021 and March 2023 among immunization programs, public health campaigns, primary care, and other health services. Countries were surveyed on integration experience and activities across planning and leadership, service delivery, demand generation, vaccine safety, logistics and cold chain, and data management systems. Integration was categorized as structured or opportunistic based on the degree of planning, analysis, and systems change. Formal planning for future integration and monitoring was also assessed.
Results
All surveyed countries had integration experience, and the majority had experience with integrating service co-delivery, planning, demand generation, and vaccine safety. Two-thirds of countries had experience with integrating logistics and cold chain systems; half of countries had integration experience with data management systems. Service delivery integration was frequently opportunistic, and vaccine safety and data systems integration was more structured. Most countries had a formal plan for full or partial integration of COVID-19 vaccine with childhood immunization, primary health care, or other activities. Half had initiated planning and preparation for future integration, and less than a third had an implementation and monitoring plan to assess integration effectiveness.
Conclusions
Data management, logistics, and cold chains are critical health system domains requiring focused investment to support sustainable integration. Integration can be facilitated through expansion of adult immunization programs to better serve at-risk populations throughout the life course. Other key recommendations include evaluating demand dynamics and customizing IEC strategies, addressing knowledge gaps, and leveraging successful partnership and technical assistance models for future vaccine introductions. These findings should inform investment and decision-making to reach high-risk populations, build capacity to respond to future public health emergencies, and increase global health security.
Trial registration:
N/A