bluuebunny/crossref_metadata_2025_split huggingface dataset:
Coordination et changement transformateur dans l’administration publique.
Authors: Defacqz Samuel , Dupuy Claire 
Published: September 2023

Le lien entre les performances réelles des pouvoirs publics et les perceptions des citoyens concernant ces performances est controversé. Toutefois, compte tenu de la prévalence du biais de négativité, le lien entre les mauvaises performances et les perceptions des citoyens pourrait sembler solide. Pour explorer ce lien théoriquement non confirmé, cette étude utilise une quasi-expérience qui compare une ville japonaise en crise budgétaire, impliquant des augmentations d’impôts et des réductions de services, à un village de contrôle qui ne connaît pas de crise budgétaire. En utilisant une analyse des doubles différences avec un pré-test rétrospectif minutieux, on observe des effets négatifs de la crise budgétaire sur la perception du processus par les citoyens, alors que l’on n’observe aucun effet sur la satisfaction du service par les citoyens et la confiance dans le maire, le conseil et les administrateurs. L’étude révèle en outre des associations positives entre les perceptions des performances chez les citoyens et l’engagement civique. Nous analysons ces résultats afin d’identifier les conditions limites dans lesquelles un lien entre mauvaises performances et perception négative est susceptible d’apparaître. Remarques à l’intention des praticiens Cet article illustre comment les processus de coordination au sein des organisations publiques dépendent du contexte et du comportement des « agents de changement » en charge de ces processus. Dans des contextes peu propices au changement (comme les structures en silo et caractérisé par la présence d’acteurs ayant un pouvoir de veto), la mise en place d’agents de changement agiles et autonomes est essentielle. Lorsque des acteurs ayant un pouvoir de veto peuvent s’opposer à des changements structurels, l’article suggère de mettre en place des processus de coordination basés sur une logique de réseau qui induisent des évolutions graduelles afin d’aboutir à des changements transformateurs.
P7C3-A20 treats traumatic brain injury in rats by inhibiting excessive autophagy and apoptosis
Authors: Yang Zhiqing , Wang Zhenchao , Deng Xiaoqi , Zhu Lingxin , Song Zhaomeng , Cao Changyu , Li Xinran 
Published: September 2023

Abstract

JOURNAL/nrgr/04.03/01300535-202405000-00037/inline-graphic1/v/2023-09-28T063346Z/r/image-tiff

Traumatic brain injury is a severe health problem leading to autophagy and apoptosis in the brain. 3,6-Dibromo-beta-fluoro-N-(3-methoxyphenyl)-9H-carbazole-9-propanamine (P7C3-A20) can be neuroprotective in various diseases, including ischemic stroke and neurodegenerative diseases. However, whether P7C3-A20 has a therapeutic effect on traumatic brain injury and its possible molecular mechanisms are unclear. Therefore, in the present study, we investigated the therapeutic effects of P7C3-A20 on traumatic brain injury and explored the putative underlying molecular mechanisms. We established a traumatic brain injury rat model using a modified weight drop method. P7C3-A20 or vehicle was injected intraperitoneally after traumatic brain injury. Severe neurological deficits were found in rats after traumatic brain injury, with deterioration in balance, walking function, and learning memory. Furthermore, hematoxylin and eosin staining showed significant neuronal cell damage, while terminal deoxynucleotidyl transferase mediated dUTP nick end labeling staining indicated a high rate of apoptosis. The presence of autolysosomes was observed using transmission electron microscope. P7C3-A20 treatment reversed these pathological features. Western blotting showed that P7C3-A20 treatment reduced microtubule-associated protein 1 light chain 3-II (LC3-II) autophagy protein, apoptosis-related proteins (namely, Bcl-2/adenovirus E1B 19-kDa-interacting protein 3 [BNIP3], and Bcl-2 associated x protein [Bax]), and elevated ubiquitin-binding protein p62 (p62) autophagy protein expression. Thus, P7C3-A20 can treat traumatic brain injury in rats by inhibiting excessive autophagy and apoptosis.
Endorepellin downregulation promotes angiogenesis after experimental traumatic brain injury
Authors: Zhang Qian , Jing Yao , Gong Qiuyuan , Cai Lin , Wang Ren , Yang Dianxu , Wang Liping , Qu Meijie , Chen Hao , Tang Yaohui , Tian Hengli , Ding Jun , Xu Zhiming 
Published: September 2023

Abstract

JOURNAL/nrgr/04.03/01300535-202405000-00039/inline-graphic1/v/2023-09-28T063346Z/r/image-tiff

Endorepellin plays a key role in the regulation of angiogenesis, but its effects on angiogenesis after traumatic brain injury are unclear. This study explored the effects of endorepellin on angiogenesis and neurobehavioral outcomes after traumatic brain injury in mice. Mice were randomly divided into four groups: sham, controlled cortical impact only, adeno-associated virus (AAV)-green fluorescent protein, and AAV-shEndorepellin-green fluorescent protein groups. In the controlled cortical impact model, the transduction of AAV-shEndorepellin-green fluorescent protein downregulated endorepellin while increasing the number of CD31+/Ki-67+ proliferating endothelial cells and the functional microvessel density in mouse brain. These changes resulted in improved neurological function compared with controlled cortical impact mice. Western blotting revealed increased expression of vascular endothelial growth factor and angiopoietin-1 in mice treated with AAV-shEndorepellin-green fluorescent protein. Synchrotron radiation angiography showed that endorepellin downregulation promoted angiogenesis and increased cortical neovascularization, which may further improve neurobehavioral outcomes. Furthermore, an in vitro study showed that downregulation of endorepellin increased tube formation by human umbilical vein endothelial cells compared with a control. Mechanistic analysis found that endorepellin downregulation may mediate angiogenesis by activating vascular endothelial growth factor- and angiopoietin-1-related signaling pathways.
Increased retinal venule diameter as a prognostic indicator for recurrent cerebrovascular events: a prospective observational study
Authors: Zhao Ying , Dong Dawei , Yan Ding , Yang Bing , Gui Weirong , Ke Man , Xu Anding , Tan Zefeng 
Published: September 2023

Abstract

JOURNAL/nrgr/04.03/01300535-202405000-00048/inline-graphic1/v/2023-09-28T063346Z/r/image-tiff

Microvasculature of the retina is considered an alternative marker of cerebral vascular risk in healthy populations. However, the ability of retinal vasculature changes, specifically focusing on retinal vessel diameter, to predict the recurrence of cerebrovascular events in patients with ischemic stroke has not been determined comprehensively. While previous studies have shown a link between retinal vessel diameter and recurrent cerebrovascular events, they have not incorporated this information into a predictive model. Therefore, this study aimed to investigate the relationship between retinal vessel diameter and subsequent cerebrovascular events in patients with acute ischemic stroke. Additionally, we sought to establish a predictive model by combining retinal veessel diameter with traditional risk factors. We performed a prospective observational study of 141 patients with acute ischemic stroke who were admitted to the First Affiliated Hospital of Jinan University. All of these patients underwent digital retinal imaging within 72 hours of admission and were followed up for 3 years. We found that, after adjusting for related risk factors, patients with acute ischemic stroke with mean arteriolar diameter within 0.5–1.0 disc diameters of the disc margin (MAD0.5–1.0DD) of ≥ 74.14 μm and mean venular diameter within 0.5–1.0 disc diameters of the disc margin (MVD0.5–1.0DD) of ≥ 83.91 μm tended to experience recurrent cerebrovascular events. We established three multivariate Cox proportional hazard regression models: model 1 included traditional risk factors, model 2 added MAD0.5–1.0DD to model 1, and model 3 added MVD0.5–1.0DD to model 1. Model 3 had the greatest potential to predict subsequent cerebrovascular events, followed by model 2, and finally model 1. These findings indicate that combining retinal venular or arteriolar diameter with traditional risk factors could improve the prediction of recurrent cerebrovascular events in patients with acute ischemic stroke, and that retinal imaging could be a useful and non-invasive method for identifying high-risk patients who require closer monitoring and more aggressive management.
ATAT1 deficiency enhances microglia/macrophage-mediated erythrophagocytosis and hematoma absorption following intracerebral hemorrhage
Authors: Zhang Yihua , Huang Ping , Cao Min , Chen Yi , Zhao Xinhu , He Xuzhi , Xu Lunshan 
Published: September 2023

AbstractJOURNAL/nrgr/04.03/01300535-202405000-00036/inline-graphic1/v/2023-09-28T063346Z/r/image-tiffMIcroglia/macrophage-mediated erythrophagocytosis plays a crucial role in hematoma clearance after intracerebral hemorrhage. Dynamic cytoskeletal changes accompany phagocytosis. However, whether and how these changes are associated with microglia/macrophage-mediated erythrophagocytosis remain unclear. In this study, we investigated the function of acetylated α-tubulin, a stabilized microtubule form, in microglia/macrophage erythrophagocytosis after intracerebral hemorrhage bothin vitroandin vivo. We first assessed the function of acetylated α-tubulin in erythrophagocytosis using primary DiO GFP-labeled red blood cells co-cultured with the BV2 microglia or RAW264.7 macrophage cell lines. Acetylated α-tubulin expression was significantly decreased in BV2 and RAW264.7 cells during erythrophagocytosis. Moreover, silencing α-tubulin acetyltransferase 1 (ATAT1), a newly discovered α-tubulin acetyltransferase, decreased Ac-α-tub levels and enhanced the erythrophagocytosis by BV2 and RAW264.7 cells. Consistent with these findings, in ATAT1–/–mice, we observed increased ionized calcium binding adapter molecule 1 (Iba1) and Perls-positive microglia/macrophage phagocytes of red blood cells in peri-hematoma and reduced hematoma volume in mice with intracerebral hemorrhage. Additionally, knocking out ATAT1 alleviated neuronal apoptosis and pro-inflammatory cytokines and increased anti-inflammatory cytokines around the hematoma, ultimately improving neurological recovery of mice after intracerebral hemorrhage. These findings suggest that ATAT1 deficiency accelerates erythrophagocytosis by microglia/macrophages and hematoma absorption after intracerebral hemorrhage. These results provide novel insights into the mechanisms of hematoma clearance and suggest ATAT1 as a potential target for the treatment of intracerebral hemorrhage.
NRF2 signaling cascade in amyotrophic lateral sclerosis: bridging the gap between promise and reality
Authors: Tarot Pauline , Lasbleiz Christelle , Liévens Jean-Charles 
Published: September 2023

Abstract
Amyotrophic lateral sclerosis is a very disabling disease due to the degeneration of motor neurons. Symptoms include muscle weakness and atrophy, spasticity, and progressive paralysis. Currently, there is no treatment to reverse damage to motor neurons and cure amyotrophic lateral sclerosis. The only two treatments actually approved, riluzole and edaravone, have shown mitigated beneficial effects. The difficulty to find a cure lies in the complexity and multifaceted pattern of amyotrophic lateral sclerosis pathogenesis. Among mechanisms, abnormal RNA metabolism, nucleocytoplasmic transport defects, accumulation of unfolded protein, and mitochondrial dysfunction would in fine induce oxidative damage and vice versa. A potent therapeutic strategy will be to find molecules that break this vicious circle. Sharpening the nuclear factor erythroid-2 related factor 2 signaling may fulfill this objective since nuclear factor erythroid-2 related factor 2 has a multitarget profile controlling antioxidant defense, mitochondrial functioning, and inflammation. We here discuss the interest of developing nuclear factor erythroid-2 related factor 2-based therapy in regard to the pathophysiological mechanisms and we provide a general overview of the attempted clinical assays in amyotrophic lateral sclerosis.
Tumor necrosis factor-stimulated gene-6 ameliorates early brain injury after subarachnoid hemorrhage by suppressing NLRC4 inflammasome-mediated astrocyte pyroptosis
Authors: Ding Mingxiang , Jin Lei , Wei Boyang , Cheng Wenping , Liu Wenchao , Li Xifeng , Duan Chuanzhi 
Published: September 2023

Abstract

JOURNAL/nrgr/04.03/01300535-202405000-00035/inline-graphic1/v/2023-09-28T063346Z/r/image-tiff

Subarachnoid hemorrhage is associated with high morbidity and mortality and lacks effective treatment. Pyroptosis is a crucial mechanism underlying early brain injury after subarachnoid hemorrhage. Previous studies have confirmed that tumor necrosis factor-stimulated gene-6 (TSG-6) can exert a neuroprotective effect by suppressing oxidative stress and apoptosis. However, no study to date has explored whether TSG-6 can alleviate pyroptosis in early brain injury after subarachnoid hemorrhage. In this study, a C57BL/6J mouse model of subarachnoid hemorrhage was established using the endovascular perforation method. Our results indicated that TSG-6 expression was predominantly detected in astrocytes, along with NLRC4 and gasdermin-D (GSDMD). The expression of NLRC4, GSDMD and its N-terminal domain (GSDMD-N), and cleaved caspase-1 was significantly enhanced after subarachnoid hemorrhage and accompanied by brain edema and neurological impairment. To explore how TSG-6 affects pyroptosis during early brain injury after subarachnoid hemorrhage, recombinant human TSG-6 or a siRNA targeting TSG-6 was injected into the cerebral ventricles. Exogenous TSG-6 administration downregulated the expression of NLRC4 and pyroptosis-associated proteins and alleviated brain edema and neurological deficits. Moreover, TSG-6 knockdown further increased the expression of NLRC4, which was accompanied by more severe astrocyte pyroptosis. In summary, our study revealed that TSG-6 provides neuroprotection against early brain injury after subarachnoid hemorrhage by suppressing NLRC4 inflammasome activation-induced astrocyte pyroptosis.
Investigating the Relationship between Early Maladaptive Schemas and Sexual Self-Confidence and Sexual Self-Efficacy in Individuals with Gender Dysphoria
Authors: Yazdkhasti Maedeh , Molaeinezhad Mitra , Tarrahi Mohammad Javad , Karahmadi Mojgan , Salimi Hajar 
Published: September 2023

Background:
Due to the negative effects of sexual identity disorder and the lack of attention from family and society, this study aimed to investigate the relationship between Young's Early Maladaptive Schemas (YEMS) and sexual self-confidence and sexual self-efficacy in individuals with gender dysphoria (GD) after surgery.

Materials and Methods:
This cross-sectional study was performed on 45 individuals with GD undergoing sex reassignment surgery (SRS). Three of YEMS questionnaire (YEMSQ), sexual self-confidence, and sexual self-efficacy were completed.

Results:
The YEMSQ score had a significant inverse relationship with sexual self-efficacy (correlation = -0.333, P-value = 0.025). In addition, dimensions of emotional deprivation, failure to achieve, dependence/incompetence, vulnerability to harm and Illness, insufficient self-control/self-discipline, and subjugation had an adverse effect on the self-confidence and sexual self-efficacy in these individuals (P-value <0.05).

Conclusion:
According to the results of this study, YEMSQ score, sexual self-confidence, and self-efficacy were not significantly different between the two groups of male-to-female (MF) and female-to-male (FM). Also, the formation or development of these schemas in childhood in these individuals can be influential in reducing their sexual self-efficacy.
Pituitary and growth disorders of pediatric survivors of head and neck tumors: a single center study
Authors: Omar Omneya M. , Aron Dotto , Haleem Abo Elwafa Reham A. , Fadel Shady H. , Raafat Shaymaa 
Published: September 2023

Objective
The aim was to explore the prevalence and risk factors for pituitary and growth disorders in pediatric brain and neck tumor survivors.

Methods
203 children with brain or neck tumors that survived 2 years after tumors treatment were included. Demographic data, anthropometric assessments, characteristics of the tumors, tumor treatment modalities, and hormonal profile evaluation were reported.

Results
After a mean follow-up of 4.77 years, 62 (30.54%) survivors were diagnosed with at least one pituitary disorder. Growth hormone deficiency (GHD) was detected in 17.28% of survivors, moreover, thyroid-stimulating hormone deficiency (TSHD), luteinizing hormone and follicle-stimulating hormone deficiency (LH/FSHD), adrenocorticotropic hormone deficiency (ACTHD)/cortisol deficiency and central precocious puberty were detected in 10.4, 9.09, 8.06, and 1.69% of survivors, respectively. The prevalence of short stature and obesity was 9.1% and 17.05%, respectively among survivors who attended follow-up clinics during data collection. The risk of developing pituitary disorders was associated with craniopharyngioma histology (OR, 6.207; 95% CI, 1.025–37.581) and a history of hydrocephalus at cancer diagnosis (OR, 3.075; 95% CI, 1.402–6.746). Older age at the time of radiotherapy was associated with a lower risk of developing pituitary disorders (OR, 0.928; 95% CI, 0.864–0.997).

Conclusion
This study observed a high prevalence of pituitary disorders among survivors of pediatric brain and neck tumors. So proper screening of pituitary disorders in survivors of brain and neck tumors is warranted.
Diagnostic and prognostic role of troponin i in neonates with critical duct-dependent congenital heart diseases
Authors: Wagdy Reham , Loweis Nevein , Abdel-Wahab Omniya , Farag Marwa 
Published: September 2023

Background
Cardiac troponins (cTn) are markers of myocardial injury with well established diagnostic value in adults. However, the benefits of using troponins in neonates with critical duct-dependent congenital cardiac diseases (cDD-CHDs) is questionable.

Aim
The study aimed to investigate the diagnostic role of cTnI in cDD-CHDs as a marker of myocardial injury and to explore its role in patient’s outcome.

Methods
A case-control study, conducted over 80 neonates; Group I: Forty neonates with cDD-CHDs and Group II: Forty healthy neonates. CBC, CRP, electrolytes, liver and kidney functions, cTnI and echocardiography were done for both groups in first week of life. Then serum level of cTnI were re-evaluated after 3 weeks from initial sampling.

Results
The mean value of serum cTnI was significantly higher among cases when compared to controls (0.91±1.88 ng/ml versus 0.003±0.006 ng/ml, P<0.001*). The diagnostic performance of cTn I for cardiac injury was at cut-off 0.03 ng/ml with sensitivity 65% and specificity 97.5%. However, the prognostic role of cTnI in predicting death was at serum level of 0.7 ng/ml with 61% sensitivity and 81% specificity. cTn I in cDD-CHD was positively correlated to the severity of heart failure (HF) based on Modified Ross Score. The mean value of survival of the cDD-CHDs neonates was 28.11 days when cTnI is >0.6 ng/ml.

Conclusion
Initial serum levels of cTnI of cDD-CHD neonates in first week of life might be a useful marker in predicting the 40-days-survival and outcome.
Determination of phosphorus by phosphorus molybdenum blue spectrophotometry by bismuth antimony sensitization
Authors: Zhai Qing-Zhou 
Published: September 2023

ABSTRACT. The determination of phosphorus in rain water is of great significance. In this paper the optimum conditions of phosphorus molybdenum blue spectrophotometric method for the determination of phosphorus content were obtained. At the maximum absorption wavelength 690 nm, the apparent molar absorptivity is ε690 nm = 1.44 × 104 L·mol-1·cm-1. Beer’s law is followed over the range of 0.02-1.8 μg·mL-1 for phosphorus(V) content. Bismuth(III) and antimony(III) as the sensitizer has a sensitization effect on the phosphomolybdenum blue photometry. The addition of both simultaneously increases the sensitivity by 71.3%. The present method has been used for the determination of phosphorus in water samples. The recovery of method is between 99.20 - 100.1% and the relative standard deviation is between 1.31-1.33% for eleven determination. The results determined by the present method were in agreement with those of atomic absorption spectrometry. This method can avoid the harm of organic reagent to human body and to environmental pollution without organic solvent extraction. This method does not need heating with room temperature color development. Compared with other methods, it has the advantages that the operation is simple, fast and the sensitivity is high.
Bull. Chem. Soc. Ethiop. 2023, 37(6), 1307-1313.
DOI: https://dx.doi.org/10.4314/bcse.v37i6.1
Synthesis and characterization of a new azo quinoline ligand and its metal complexes with spectrophotometric determination and biological efficacy study of its Hg(II) complex
Authors: Radhi Esraa Rasool , Ali Fatema Jabbar , Ali Khdeeja Jabbar 
Published: September 2023

ABSTRACT. An azo quinoline ligand, (E)-2-((4-iodophenyl)diazenyl)-8-hydroxyquinoline (IPDHQ), was synthesized by the coupling reaction of 4-iodoaniline diazonium salt with 8-hydroxyquinoline. The synthesized ligand and its Cd(II), Pd(II), Cu(II) and Hg(II) complexes were spectrally characterized by UV‒Vis spectrophotometry, FT-IR, mass spectral analysis, 1H-NMR, magnetic sensitivity and molar conductivity. The general formula of the Cd(II), Cu(II) and Hg(II) complexes is [M(L)2].Cl2.H2O with octahedral geometry, while the general formula of the Pd(II) complex is [M(L).Cl2].H2O with square planer geometry. A simple and rapid spectrophotometric procedure was suggested for the determination of Hg(II) using the synthesized ligand as a spectrophotometric reagent. By measuring the absorbance for the resulting orange complex at 430 nm, the linearity range was 0.5-15 µg mL-1, and the interfering effect was also studied. The synthesized azo ligand and its Hg(Ⅱ) complex were tested for their biological activity against four bacterial strains.
KEY WORDS: Azo quinoline ligand, 8-Hydroxy quinoline, 4-Iodoaniline, Azo metal complexes, Spectrophotometric determination, Biological efficacy study
Bull. Chem. Soc. Ethiop. 2023, 37(6), 1459-1470. DOI: https://dx.doi.org/10.4314/bcse.v37i6.13
Phytochemical analysis and biological activities of two oil-bearing extracts from fresh Pistacia lentiscus
Authors: Abidi Omayma , Abdelkafi-Koubaa Zaineb , Fares-Zagrouba Nadia , Elkahoui Salem , Toumi Lamjed , Marzouki Lamjed , Souilem Ouajdi 
Published: September 2023

ABSTRACT. This study aims to investigate the anti-cancer, antimicrobial and antioxidant activities of Pistacia lentiscus L. (P. lentiscus) extracts, as well as their phyto-chemical profile. The GC-MS crude chemical profile provided new chemotypes of fixed oil (FO) and essential oil (EO) extracts. Secondary metabolites screened high levels of polyphenols and condensed tannins in EO, while FO had the highest flavonoids content. A potent anti-proliferative activity of both extracts was shown on two human breast cancer cells (EO-IC50 = 5.2 mg/mL MDA-MB-231 cells). The antimicrobial activity showed that only EO was active against six multidrug resistant bacteria (inhibition zone 20-8 mm) and two fungi strains (inhibition zone 3-4 mm). Also, the highest in vitro antioxidant free-radical scavenging ability was in the case of EO (125.5 μg/mL). In vivo P. lentiscus EO provided corrective effect vs the tamoxifen (Txf) induced oxidative damage in liver and kidney in C57BL/6 in female mouse. These findings confirm that EO inhibits cell proliferation, induces bacterial death and has a potential antioxidant activity.
KEY WORDS: Phytotherapy, Pistacia lentiscus, Antioxidant, Antimicrobial activity, Breast cancer
Bull. Chem. Soc. Ethiop. 2023, 37(6), 1487-1501. DOI: https://dx.doi.org/10.4314/bcse.v37i6.15