bluuebunny/crossref_metadata_2025_split huggingface dataset:
Titanium clips and ligamentum flavum–epidural fat patch graft for midline lumbar durotomy closure in pediatric neurosurgery
Authors: Shields Lisa B. E. , Mutchnick Ian S. 
Published: January 2025

OBJECTIVE
CSF leaks are a significant source of patient morbidity following intradural spine surgeries. Watertight dural closure is crucial during these procedures to minimize the risk of a CSF leak. This study reports postoperative outcomes and changes in patient management after switching to penetrating titanium clips for dural closure in a large cohort of pediatric patients receiving a tethered cord release (TCR) or a selective dorsal rhizotomy (SDR).

METHODS
An IRB-approved retrospective review was conducted of the medical charts of all patients who underwent thoracolumbar dorsal midline dural closure with the AnastoClip GC Closure System during the 7 years between May 22, 2017, and May 21, 2024. Selected data such as evidence of a CSF leak and postoperative length of stay were collected.

RESULTS
A total of 290 patients were treated with AnastoClips GC for dural closure. Of these patients, 232 (80.0%) underwent a TCR only, 52 (17.9%) received an SDR, and 6 (2.1%) underwent a complex TCR. The mean duration between surgery and last follow-up was 7.96 months (range 0.27–54.57 months). One patient, who received a simple TCR, experienced a transient pseudomeningocele without headache, emesis, or visible leak that resolved without surgical intervention within 8 weeks. Three (1%) patients had positional headaches without other evidence of a CSF leak, all limited to the initial 2 weeks of postoperative care. Six (2%) patients had delayed wound healing, 2 of whom underwent operative wound revisions. As of January 1, 2021, patients no longer had to lie flat postoperatively. While 60.6% of TCR patients were discharged from the hospital on POD 1 (none on POD 0) prior to this date, 87.5% of patients were discharged from the hospital on either POD 0 (3.1%) or POD 1 (84.4%) afterward. Similarly, 50% of SDR patients were discharged on POD 2 or 3 after the need for lying flat postoperatively was removed versus 21% before the protocol change.

CONCLUSIONS
AnastoClip GC Closure System titanium clips are safe and effective for dural closure in both TCR and SDR, with rare complications. Their efficacy has prompted us to remove flat bed rest requirements for postoperative patients, significantly reducing the length of stay, and has opened the door to making simple TCRs a same-day surgery.
A novel posterior decompression technique (anterior sliding decompression osteotomy) for beak-type ossification of the posterior longitudinal ligament in the thoracic spine
Authors: Park Jin-Sung , Kim Hyun-Jun , Park Se-Jun , Kang Dong-Ho , Lee Chong-Suh 
Published: January 2025

OBJECTIVE
Conventional decompression surgery for beak-type ossification of the posterior longitudinal ligament (OPLL) of the thoracic spine, whether approached anteriorly or posteriorly, poses several challenges, including technical complexity, cerebrospinal fluid leakage, incomplete decompression, and potential neurological deterioration. Therefore, the authors introduce a novel technique, anterior sliding decompression osteotomy (ASDO), for thoracic myelopathy caused by OPLL and evaluate the efficacy and safety of this technique.

METHODS
Six patients (4 men and 2 women) who underwent ASDO surgery for beak-type OPLL in the thoracic spine with a follow-up period of at least 2 years were included in the cohort. Clinical and surgical outcomes, including modified Japanese Orthopaedic Association (mJOA) score, neurological recovery rate, canal occupying ratio, operation time, and blood loss, were evaluated.

RESULTS
The mean ± SD follow-up period was 26.5 ± 2.0 months. The mean mJOA score improved from 6.0 to 9.7, with the mean recovery rate reaching 63.6% at 6 weeks postoperatively to 73.9% at 2 years after surgery. Neural decompression was effective in all patients, reducing the mean canal occupying ratio from 70.8% to 29.1% without complications.

CONCLUSIONS
ASDO surgery achieves sufficient spinal cord decompression for beak-type OPLL in the thoracic spine. It represents an effective, feasible technique, offering surgeons a familiar view from the conventional posterior approach.
Clinical significance of intraoperative bidirectional corticocortical evoked potential monitoring to evaluate language function
Authors: Kamada Chie , Kimura Yusuke , Yamada Shoto , Saito Ryohei , Komatsu Katsuya , Enatsu Rei , Akiyama Yukinori , Mikuni Nobuhiro 
Published: January 2025

OBJECTIVE
Awake craniotomy is commonly used to resect lesions located near the language area during brain surgery. However, it is often difficult to perform language tasks due to several limitations such as difficulty in awakening during surgery and intraoperative seizures. This study investigated the clinical significance of bidirectional corticocortical evoked potential (CCEP) monitoring as a new approach to evaluate intraoperative language function.

METHODS
This study enrolled 12 patients who underwent awake brain tumor resection with intraoperative CCEP monitoring to assess language function. Electrodes were placed on the frontal and temporoparietal lobes based on the location of the arcuate fasciculus identified with preoperative diffusion tensor imaging to measure CCEPs intraoperatively in two directions: from the frontal lobe to the temporoparietal lobe of the language-dominant side, and vice versa. Correlations between CCEP amplitudes or latencies before and after tumor removal in each direction and postoperative language function assessed with the Western Aphasia Battery were analyzed.

RESULTS
Nine of the 12 patients showed language-related CCEP responses in both directions before, during, and after tumor removal. One patient who showed decreased CCEP amplitudes in both directions after tumor removal exhibited aphasia for as long as 1 month postoperatively. In contrast, of the 6 patients whose CCEP amplitude in only a single direction was reduced or disappeared, 4 had no deterioration of language function and the other 2 had temporary deterioration of language function during the 1st postoperative week, which improved by 1 month postoperatively.

CONCLUSIONS
This study indicated that bidirectional CCEP measurement may increase the precision of intraoperative language function monitoring.
Imaging characteristics and treatment of recurrent germinoma
Authors: Dowaki Ryosuke , Yamasaki Fumiyuki , Kinoshita Yasuyuki , Watanabe Yosuke , Yonezawa Ushio , Taguchi Akira , Onishi Shumpei , Ozono Iori , Horie Nobutaka 
Published: January 2025

OBJECTIVE
An MRI protocol for germinoma surveillance after complete remission has not been established. Moreover, the standard treatment for recurrent or refractory germinoma has not been determined. In this study, the authors explored the imaging characteristics of recurrent germinoma and discuss their institution’s experience with multidisciplinary treatment of this malignancy.

METHODS
The medical records of 16 patients (14 male, 2 female) with recurrent germinoma and 62 patients (52 male, 10 female) without recurrence who were treated at the authors’ institution between 1989 and 2023 were retrospectively examined. Data including diagnostic imaging, tumor markers, treatment at diagnosis and recurrence, and overall survival were collected from patients’ medical records and statistically analyzed.

RESULTS
No patients with recurrence received craniospinal irradiation (CSI) as an initial therapy, and local irradiation was a significant risk factor of recurrence (p = 0.0072). The period between the start of first-line treatment and confirmation of the first recurrence ranged from 4.2 to 272 months (median 66.8 months). Among the recurrences, 13 tumors occurred outside the radiation field, including 6 cases of spinal cord/canal recurrence. One-third of patients did not exhibit elevated tumor marker levels in the serum. Fourteen patients had contrast-enhanced recurrent lesions. In the 2 patients with non–contrast-enhanced lesions, recurrence was detected by high signal intensity on diffusion-weighted imaging (DWI) and elevated tumor marker levels in CSF. Fifteen patients received chemotherapy for the first recurrence, and 14 received radiation therapy, with 9 receiving CSI. The patients who received CSI survived without further recurrence during the study period. However, the median progression-free survival and overall survival after the first recurrence among patients who did not undergo CSI were 12.2 and 37.4 months, respectively, which were shorter than those for patients treated with CSI (both p < 0.01, log-rank test).

CONCLUSIONS
Spinal MRI for surveillance in patients with recurrent germinoma, especially for those who do not receive CSI, is recommended. DWI might be useful for detecting recurrent germinoma. Aggressive treatment at the time of recurrence is crucial, and even if remission is achieved with chemotherapy, CSI for consolidation is important to prevent further recurrence.
Improved accuracy of delayed cerebral ischemia diagnosis with plasma nitric oxide synthase 3, nicotinamide adenine dinucleotide phosphate, and 8-iso-prostaglandin F2α
Authors: Wiśniewski Karol , Zaczkowski Karol , Popęda Marta , Urbanowicz Krzysztof , Szmyd Bartosz , Price Benjamin , Bieńkowski Michał , Bobeff Ernest J. , Opiełka Mikołaj , Fahlström Andreas , Jaskólski Dariusz J. , Smoleński Ryszard T. , Drummond Katharine , Adamides Alexios A. 
Published: January 2025

OBJECTIVE
The pathophysiology of delayed cerebral ischemia (DCI) is not fully elucidated. The lack of accurate diagnostic tools increases the probability of delayed diagnosis and timely treatment. The authors assessed the relationship of 8-iso-prostaglandin F2α (F2-IsoP) and oxidative stress biomarkers, nitric oxide synthase 3 (NOS3) and nicotinamide adenine dinucleotide phosphate (NADPH), with DCI after aneurysmal subarachnoid hemorrhage (aSAH).

METHODS
The authors assessed 65 aSAH patients for F2-IsoP, NOS3, and NADPH concentrations using commercial ELISA on days 2, 4, and 6 after aSAH. The authors examined the correlations of plasma F2-IsoP, NOS3, and NADPH concentrations and clinical variables with DCI onset.

RESULTS
F2-IsoP, NOS3, and NADPH are important laboratory predictors of DCI. Of the clinical predictors, modified Fisher grade, Hunt and Hess grade, and tobacco smoking were the most significant predictors. In patients with DCI, plasma F2-IsoP and NOS3 concentrations were higher, and NADPH concentrations were lower, than in those without DCI (p < 0.01). Plasma F2-IsoP concentration on day 2, and NADPH and NOS3 concentrations on day 6, correlated with DCI occurrence (p < 0.01).

CONCLUSIONS
The authors observed decreased antioxidant capacity in patients with DCI, which may be explained by increased F2-IsoP and decreased NADPH. Assessment of F2-IsoP, NOS3, and NADPH may improve the diagnostic accuracy of DCI. Further work is required to determine the role of F2-IsoP, NOS3, and NADPH in clinical practice and DCI pathophysiology.
Conflict Management Skills Development in Education Transformation for Teachers of SMA Negeri 13 Ambon
Authors: Ayhuan Welhelmina Febriana , Satori Djam'an , Nurdin Diding , Meirawan Danny 
Published: January 2025

SMA Negeri 13 Ambon, as one of the driving schools in Ambon City, is currently sustaining to carry out transformation efforts comprehensively. This effort certainly raises many sources of conflicts, which, if managed properly, will actually become constructive conflicts that encourage the transformation process. Unfortunately, conflict that happened internally in the school is regarded negative by most of the teachers at the school and actually eventually hinder the transformation process at school. This has a great impact on the teacher's lack of ability to manage conflict in the school. Through the program of Musyawarah Guru Mata Pelajaran (MGMP), teachers are equipped with the correct understanding of conflict and how to manage conflict appropriately so that it is beneficial for the transformation process at SMA Negeri 13 Ambon.
The Utilization of Cassava Peel into Cassava Peel Chips in KUB Sejahtera
Authors: Ihsan Fikratul , Nizar* Rini , Khairani Zulia 
Published: January 2025

KUB Sejahtera merupakan UMKM yang memproduski kripik singkong berlokasi di Kecamatan Tenayan Raya. Satu kali proses produksi menghasilkan 400 bungkus dari 150 kg singkong. Limbah kulit singkong yang dihasilkan mencapai 7-8 kg sekali proses produksi. Pemanfaatan limbah kulit singkong menjadi produk yang bernilai ekonomi perlu untuk dilakukan. Salah satu produk yang dapat dihasilkan dari limbah kulit singkong adalah kripik kulit singkong. Peningkatan pegetahuan mitra terhadap pemanfaatan limbah kulit singkong dapat dilakukan dengan mengadakan pelatihan dan praktik pembuatan kripik kulit singkong. Pengabdian ini bertujun untuk meningkatkan pengetahuan mitra dalam mengolah kripik kulit singkong. Keberhasilan pelatihan dilihat dari peningkatan pengetahuan mitra melalui kuesioner yang dibagikan sebelum dan setelah dilakukan pelatihan. Berdasarkan data kuesioner terjadi peningkatan pengetahuan mitra sebesar 100% terhadap proses pembuatan kripik kulit singkong. Selain itu, dilakukan pengujian organoleptik terhadap kripik kulit singkong. Kripik kulit singkong dengan baluran tepung serbaguna lebih disukai dibandingkan dengan penggunaan tepung yang diracik sendiri. Tingkat kesukaan panelis terhadap tekstur, rasa dan aroma yakni 4,42 (suka), sedangkan untuk warna yakni 4.25 (suka).

Kata kunci: kripik kulit singkong, pemanfaatan limbah, pelatihan, organoleptik
A MODALIZAÇÃO ESPIRITUAL DO SABER DESDE O PONTO DE VISTA DE GURU RINPOCHE: NOTAS PARA NÃO DESISTIR DE PENSAR (OUTRAMENTE) OS DESAFIOS DA FORMAÇÃO HUMANA NA CONTEMPORANEIDADE
Authors: Rocha da Silva Silas Carlos , Simão de Freitas Alexandre 
Published: January 2025

Ancorado no desejo de contribuir com a tarefa permanente de "descolonização do pensamento" (VIVEIROS DE CASTRO, 2015), o presente artigo aposta na possibilidade de pensar sobre os desafios da formação humana, assumindo como principal chave de leitura o campo nocional da Espiritualidade Budista corporificada no saber espiritual de um mestre indiano do Século VIII chamado Guru Rinpoche. Através de uma investigação de caráter teórico-bibliográfico, pretende-se mostrar que a modalização espiritual do saber, desde o ponto de vista de Guru Rinpoche, pode abrir novos meios de percepção do ato educativo. O pressuposto imanente é que o diálogo interfilosófico entre Educação e Budismo, além de contribuir para revitalizar e enriquecer os debates em torno da formação humana, compromete o campo com a superação de discursos e práticas duais que contribuem para perpetuar a lógica da colonialidade dos saberes. No limite, espera-se que este trabalho possibilite abrir um ethos de escuta a outros pontos de vista.
Mann sein ...!?
Authors: Theunert Markus , Luterbach Matthias 
Published: January 2025

Wenn Männlichkeit kulturell und sozial vermittelt ist, muss sie auch veränderbar sein. Aber wie? Markus Theunert und Matthias Luterbach nutzen Erkenntnisse, Einsichten und Erfahrungen aus Geschlechterforschung und Männerarbeit, um einen Orientierungsrahmen für die geschlechterreflektierte Arbeit mit Jungen, Männern und Vätern zu entwickeln. Sie zeigen, wie Fachleute Männer in ihrer Auseinandersetzung unterstützen und begleiten können.
Determination of sex hormones levels in patients with migraine
Authors: Khalimova Kh. M. , Rashidova N. S. , Kholmuratova B. N. , Agabekova E. S. , Adzhieva M. D. , Manysheva K. B. 
Published: January 2025

Relevance. Primary headaches are currently one of the most common neurological diseases, and the role of sex hormones in their occurrence has been proven.The purpose of the study is to analyze the levels of sex hormones (estradiol and testosterone) in the blood of patients with various clinical forms of migraine during an attack and outside of an attack.Materials and methods. The study included 60 patients aged 18–45 years with migraine, who formed the main group. Each patient in the main group was diagnosed according to the International Classification of Headache Disorders, Third Revision (ICHD3). The control group consisted of 15 practically healthy individuals, comparable in age with the main group, who did not suffer from migraine. The study was conducted inpatient and outpatient in a multidisciplinary clinic of the Center for Advanced Professional Development of Medical Workers, the clinical base of the Department of Neurology and Medical Psychology of the Tashkent Medical Academy.Results. The study examined the concentration of sex hormones – testosterone and estradiol – in the blood serum of female and male patients with migraine with and without aura during an attack and outside of an attack, and compared the obtained values with the results of studies in the control group. The level of estradiol is higher in women and men with migraine with aura, which affects the duration and intensity of attacks. In women with migraine without aura, the level of estradiol in the blood decreases in the 1st phase of the menstrual cycle, and its normal value in the 2nd phase is associated with the duration of the headache attack. No statistically significant change in testosterone levels was noted.Conclusions. Our data can be used for considering the possibility of hormonal therapy as a preventive measure against headache attacks in patients with various clinical forms of migraine.
Evaluation of the effectiveness and tolerability of diacerein in patients with osteoarthritis of the knee and hip joints
Authors: Toporkov M. M. , Aganov D. S. , Svintsitskaya I. S. 
Published: January 2025

Aim: to evaluate the effectiveness and tolerability of the domestic drug Diacerein-SZ in patients with osteoarthritis of the knee and hip joints.Patients and Methods. A single-center clinical prospective study was conducted, which included patients with osteoatritis and metabolic syndrome. 65 patient with OA of the knee and/or hip joints of stage II–III according to Kellgren–Lawrence with pain intensity >30 mm on a visual analog scale, aged 40 to 71 years, was examined. The duration of therapy was 6 months: 1 month – taking the drug Diacerein-SZ at a dose of 50 mg/day, then 5 months at 50 mg 2 times a day. During each visit, pain syndrome (VAS, mm), BMI, and biochemical blood tests were assessed. Data on the use of additional drugs with anti-inflammatory effects, as well as adverse events, were analyzed.Results. The average age of patients was 55.5 [49.5; 58] years. A pronounced anti-inflammatory effect was noted in the form of a decrease in the level of VAS and CRP (p <0.0001), which led to the complete abolition of NSAIDs by the end of the study in 67.7% of the subjects. A statistically significant decrease in uric acid and glycated hemoglobin was observed already by week 12 of the study (p = 0.011), (p = 0.0001), respectively. There were no significant differences in lipid profile and glucose levels (p >0.05). Adverse events were recorded in 12.9% of patients.Conclusion. The use of the domestic drug Diacerein-SZ in patients with osteoarthritis led to a decrease in the need for NSAIDs, had a favorable effect profile on the level of uric acid and glycated hemoglobin, and was well tolerated.
Electrotherapy in the Combined Treatment of Patients with Chronic Migraine and Cervicalgia
Authors: Soskin V. M. 
Published: January 2025

Chronic Migraine and Cervicalgia Significantly Impact Patients’ Quality of Life. Botulinum Therapy is an Effective Treatment, but Its Limited Efficacy as Monotherapy Necessitates the Development of Combined Approaches.Objective. To compare the effectiveness of botulinum therapy and its combination with electrotherapy in patients with chronic migraine and cervicalgia.Materials and Methods. The study included 58 patients divided into two groups: the first group (n = 30) received botulinum therapy, while the second group (n = 28) underwent electrotherapy combined with botulinum therapy. Pain severity was assessed before treatment, and at 1 and 3 months after therapy initiation.Results. After a month of treatment, in group II there was a significant decrease in the frequency of headache attacks, cervicalgia and the number of analgesics taken compared to group I. After 3 months, scores continued to improve, with no significant difference between groups.Conclusions. The combined use of electrotherapy and botulinum therapy effectively reduces pain at all stages of observation.
Clinical experience with the third-generation antipsychotic brexpiprazole in the treatment of schizophrenia spectrum disorders in a psychiatric inpatient settings
Authors: Chumakov E. M. , Bugorskij A. V. , Limankin O. V. 
Published: January 2025

Objective: to summarize the clinical experience of the antipsychotic brexpiprazole in the treatment of schizophrenia spectrum disorders in a psychiatric hospital.Materials and Methods. A group of 26 patients (16 women; 61.5%) aged 19 to 64 years (mean age 35.73±9.33) with leading delusional, hallucinatorydelusional, manic-delusional, depressive-delusional or depressive-paranoid symptomatology constituted the study material. Patients were followed up for 6 weeks after brexpiprazole administration. The severity of psychotic symptomatology was assessed by selected items of the Positive and Negative Syndrome Rating Scale (PANSS). The General Clinical Impression Scale (CGI) was used for objective assessment of the patients' condition: the severity of condition subscale (CGI-S) and the mental status dynamics subscale (CGI–I). Patients' satisfaction with therapy was assessed in the dynamics of treatment and after the end of the follow-up period.Results. Brexpiprazole was administered both on admission to hospital (65.4%) and after prior antipsychotic therapy (34.6%). The range of maximum doses was 2 to 4 mg per day. Side reactions were registered in 3 cases (11.5%), and only in one case it required withdrawal of the drug. Statistically significant improvement of mental state by the 7th day of therapy was registered for the majority of PANSS items (Delirium, Suspiciousness, Agitation, Anxiety, Tension, Aggressiveness). A statistically significant decrease in the severity of mental state according to CGI was observed from the second week of therapy. A distinct dynamics of change of attitude to therapy towards positive attitude to therapy was established (p=0,029).Conclusions: clinical experience of brexpiprazole use in psychiatric inpatient settings demonstrated good results both in terms of therapy efficacy and safety, which allows us to evaluate the drug as promising for use in the treatment of psychotic exacerbations and maintenance therapy of patients with schizophrenia and schizophrenia spectrum disorders.