bluuebunny/crossref_metadata_2025_split huggingface dataset:
NeuM: A Neuron‐Selective Probe Incorporates into Live Neuronal Membranes via Enhanced Clathrin‐Mediated Endocytosis in Primary Neurons
Authors: Sung Yoonsik , Gotina Lizaveta , Kim Kyu Hyeon , Lee Jung Yeol , Shin Seulgi , Aziz Hira , Kang Dong Min , Liu Xiao , Hong Na‐Kyeong , Lee Hong‐Guen , Lee Jun‐Seok , Ku Hyeyeong , Jeong Cherlhyun , Pae Ae Nim , Lim Sungsu , Chang Young‐Tae , Kim Yun Kyung 
Published: December 2023

AbstractThe development of a small‐molecule probe designed to selectively target neurons would enhance the exploration of intricate neuronal structures and functions. Among such probes, NeuO stands out as the pioneer and has gained significant traction in the field of research. Nevertheless, neither the mechanism behind neuron‐selectivity nor the cellular localization has been determined. Here, we introduce NeuM, a derivative of NeuO, designed to target neuronal cell membranes. Furthermore, we elucidate the mechanism behind the selective neuronal membrane trafficking that distinguishes neurons. In an aqueous buffer, NeuM autonomously assembles into micellar structures, leading to the quenching of its fluorescence (Φ=0.001). Upon exposure to neurons, NeuM micelles were selectively internalized into neuronal endosomes via clathrin‐mediated endocytosis. Through the endocytic recycling pathway, NeuM micelles integrate into neuronal membrane, dispersing fluorescent NeuM molecules in the membrane (Φ=0.61). Molecular dynamics simulations demonstrated that NeuM, in comparison to NeuO, possesses optimal lipophilicity and molecular length, facilitating its stable incorporation into phospholipid layers. The stable integration of NeuM within neuronal membrane allows the prolonged monitoring of neurons, as well as the visualization of intricate neuronal structures.
Phase‐Regulated Active Hydrogen Behavior on Molybdenum Disulfide for Electrochemical Nitrate‐to‐Ammonia Conversion
Authors: Wang Yuting , Xu Yue , Cheng Chuanqi , Zhang Baoshun , Zhang Bin , Yu Yifu 
Published: December 2023

AbstractElectrochemical reduction of nitrate waste is promising for environmental remediation and ammonia preparation. This process includes multiple hydrogenation steps, and thus the active hydrogen behavior on the surface of the catalyst is crucial. The crystal phase referred to the atomic arrangements in crystals has a great effect on active hydrogen, but the influence of the crystal phase on nitrate reduction is still unclear. Herein, enzyme‐mimicking MoS2 in different crystal phases (1T and 2H) are used as models. The Faradaic efficiency of ammonia reaches ≈90 % over 1T‐MoS2, obviously outperforming that of 2H‐MoS2 (27.31 %). In situ Raman spectra and theoretical calculations reveal that 1T‐MoS2 produces more active hydrogen on edge S sites at a more positive potential and conducts an effortless pathway from nitrate to ammonia instead of multiple energetically demanding hydrogenation steps (such as *HNO to *HNOH) performed on 2H‐MoS2.
Anion Sensing through Redox‐Modulated Fluorescent Halogen Bonding and Hydrogen Bonding Hosts**
Authors: Taylor Andrew J. , Hein Robert , Patrick Sophie C. , Davis Jason J. , Beer Paul D. 
Published: December 2023

AbstractAnion sensing via either optical or electrochemical readouts has separately received enormous attention, however, a judicious combination of the advantages of both modalities remains unexplored. Toward this goal, we herein disclose a series of novel, redox‐active, fluorescent, halogen bonding (XB) and hydrogen bonding (HB) BODIPY‐based anion sensors, wherein the introduction of a ferrocene motif induces remarkable changes in the fluorescence response. Extensive fluorescence anion titration, lifetime and electrochemical studies reveal anion binding‐induced emission modulation through intramolecular photoinduced electron transfer (PET), the magnitude of which is dependent on the nature of both the XB/HB donor and anion. Impressively, the XB sensor outperformed its HB congener in terms of anion binding strength and fluorescence switching magnitude, displaying significant fluorescence turn‐OFF upon anion binding. In contrast, redox‐inactive control receptors display a turn‐ON response, highlighting the pronounced impact of the introduction of the redox‐active ferrocene on the optical sensing performance. Additionally, the redox‐active ferrocene motif also serves as an electrochemical reporter group, enabling voltammetric anion sensing in competitive solvents. The combined advantages of both sensing modalities were further exploited in a novel, proof‐of‐principle, fluorescence spectroelectrochemical anion sensing approach, enabling simultaneous and sensitive read out of optical and electrochemical responses in multiple oxidation states and at very low receptor concentration.
Confined Lewis Pairs: Investigation of the X−→Si20 Interaction in Halogen‐Encapsulating Silafulleranes
Authors: Gasevic Thomas , Bamberg Marcel , Wicke Julius , Bolte Michael , Virovets Alexander , Lerner Hans‐Wolfram , Grimme Stefan , Hansen Andreas , Wagner Matthias , Bursch Markus 
Published: December 2023

AbstractA joint theoretical and experimental study on 32 endohedral silafullerane derivatives [X@Si20Y20]− (X=F‐I; Y=F‐I, H, Me, Et) and
‐[Cl@Si20H12Y8]− (Y=F‐I) is presented. First, we evaluated the structure‐determining template effect of Cl− in a systematic series of concave silapolyquinane model systems. Second, we investigated the X−→Si20 interaction energy (
) as a function of X− and Y and found the largest
values for electron‐withdrawing exohedral substituents Y. Given that X− ions can be considered as Lewis bases and empty Si20Y20 clusters as Lewis acids, we classify our inseparable host–guest complexes [X@Si20Y20]− as “confined Lewis pairs”. Third, 35Cl NMR spectroscopy proved to be highly diagnostic for an experimental assessment of the Cl−→Si20 interaction as the paramagnetic shielding and, in turn,
(35Cl) of the endohedral Cl− ion correlate inversely with
. Finally, we disclose the synthesis of [PPN][Cl@Si20Y20] (Y=Me, Et, Br) and provide a thorough characterization of these new silafulleranes.
Catalytic Protein Inhibitors
Authors: Kodadek Thomas 
Published: December 2023

AbstractMany of the highest priority targets in a wide range of disease states are difficult‐to‐drug proteins. The development of reversible small molecule inhibitors for the active sites of these proteins with sufficient affinity and residence time on‐target is an enormous challenge. This has engendered interest in strategies to increase the potency of a given protein inhibitor by routes other than further improvement in gross affinity. Amongst these, the development of catalytic protein inhibitors has garnered the most attention and investment, particularly with respect to protein degraders, which catalyze the destruction of the target protein. This article discusses the genesis of the burgeoning field of catalytic inhibitors, the current state of the art, and exciting future directions.
Cobalt‐Mediated [3+1] Fragmentation of White Phosphorus: Access to Acylcyanophosphanides
Authors: Hauer Sebastian , Horsley Downie Thomas M. , Balázs Gábor , Schwedtmann Kai , Weigand Jan J. , Wolf Robert 
Published: December 2023

AbstractDespite the accessibility of numerous transition metal polyphosphido complexes through transition‐metal‐mediated activation of white phosphorus, the targeted functionalization of Pn ligands to obtain functional monophosphorus species remains challenging. In this study, we introduce a new [3+1] fragmentation procedure for cyclo‐P4 ligands, leading to the discovery of acylcyanophosphanides and ‐phosphines. Treatment of the complex [K(18c‐6)][(Ar*BIAN)Co(η4‐P4)] ([K(18c‐6)]3, 18c‐6=[18]crown‐6, Ar*=2,6‐dibenzhydryl‐4‐isopropylphenyl, BIAN=1,2‐bis(arylimino)acenaphthene diimine) with acyl chlorides results in the formation of acylated tetraphosphido complexes [(Ar*BIAN)Co(η4‐P4C(O)R)] (R=tBu, Cy, 1‐Ad, Ph; 4 a–d). Subsequent reactions of 4 a–d with cyanide salts yield acylated cyanophosphanides [RC(O)PCN]− (9 a–d−) and the cyclo‐P3 cobaltate anion [(Ar*BIAN)Co(η3‐P3)(CN)]− (8−). Further reactions of 4 a–d with trimethylsilyl cyanide (Me3SiCN) and isocyanides provide insight into a plausible mechanism of this [3+1] fragmentation reaction, as these reagents partially displace the P4C(O)R ligand from the cobalt center. Several potential intermediates of the [3+1] fragmentation were characterized. Additionally, the introduction of a second acyl substituent was achieved by treating [K(18c‐6)]9b with CyC(O)Cl, resulting in the first bis(acyl)monocyanophosphine (CyC(O))2PCN (10).
Facile Synthesis of Anhydrous Rare‐Earth Trichlorides from their Oxides in Chloridoaluminate Ionic Liquids
Authors: Shah Sameera , Pietsch Tobias , Ruck Michael 
Published: December 2023

AbstractWide applications of anhydrous rare‐earth (RE) trichlorides RECl3 in organometallic chemistry, for the synthesis of optical and magnetic materials, and as catalysts require a facile approach for their synthesis. The known methods use or produce toxic substances, are complicated and have limited reliability and upscaling. It has been shown that task‐specific ionic liquids (ILs) can dissolve many metal oxides without special reaction conditions at moderate temperature, making the metals accessible to downstream chemistry. Using imidazolium chloridoaluminate ILs, pure crystalline anhydrous RECl3 (RE=La−Nd, Sm−Dy) can be synthesized in one step from RE oxides in high yield. The Lewis acidic IL acts as solvent and reaction partner. The by‐product [Al4O2Cl10]2−, which was detected spectroscopically, remains in solution. The reacted IL can be removed quantitatively by washing. ILs with various imidazolium cations and AlCl3 content and the effect of temperature and reaction time were tested.
Poly(methyl methacrylate)/hyperbranched polysiloxane hybrid prepared by gamma‐radiation polymerization: Thermal stability, optical transparence, and UV shielding
Authors: Dong Chunlei , Mao Xuanzhi , Liang Qingru , Wang Minglei , Zhang Maojiang , Chen Jianbing , Hu Jiangtao , Wu Guozhong 
Published: December 2023

AbstractIt is challenging to endow poly(methyl methacrylate) (PMMA) with good dielectric properties and UV absorption capacity while simultaneously overcoming its poor heat resistance. Herein, we report for the first time a novel organic–inorganic hybrid (PMMA‐HBPSi) derived from methyl methacrylate (MMA) and hyperbranched polysiloxane (HBPSi) fabricated via γ‐radiation curing. The typical properties (thermal stability, optical characteristics, and dielectric properties) of the hybrids were systematically investigated and discussed. The results demonstrated that the incorporation of HBPSi into the PMMA resin not only increased the thermal resistance, dimensional stability, and dielectric properties but also remarkably reduced the UV transmittance. Specifically, in comparison with pure PMMA, the initial degradation temperature (Tdi) of PMMA‐HBPSi increased by 31°C, with no phase transition occurred in a temperature range of 60–230°C, thus illustrating a significant improvement in the glass‐transition temperature. Moreover, the thermal expansion coefficient decreased by 86.9% at temperatures exceeding 118°C. The UV transmittance of PMMA was also found to decrease by 80% at 295 nm after the introduction of HBPSi. These attractive features of PMMA‐HBPSi demonstrate that the new approach proposed here is suitable for developing high‐performance organic glasses for optical, aviation, and electronic applications.
Tuning physical properties of polyurethane hard segments through extender chain length variation and doping of pentaerythritol and their effect on in vitro protein adsorption
Authors: Wagh Shrish G. , Sahani Mayur H. , Soni Hemant P. 
Published: December 2023

AbstractThis study explores the synthesis and characterization of polyurethanes (PUs) derived from hexamethylene diisocyanate (HDI) and 1,n‐alkane diols with varying chain lengths (n = 4, 6, and 10). Additionally, pentaerythritol (PE) is introduced as a dopant in PU6 at different weight percentages (25%, 50%, 75%, and 1:1%w/w). The research encompasses a comprehensive analysis of PU properties, including morphology, crystallinity, surface area, porosity, thermal behavior, rheological properties, and electrical conductivity. Of particular interest is the evaluation of protein adsorption capabilities employing bovine serum albumin (BSA) and fibrinogen proteins in in vitro tests. The study emphasizes the crucial role played by the chain length between isocyanate and diol groups and the nature and strength of hydrogen bonds among chains in shaping the polymer's properties, especially crystallinity and biocompatibility. Among the synthesized PUs, PU6 emerges as the top performer in terms of crystallinity and biocompatibility. Furthermore, the addition of PE is found to act as a plasticizer, reducing the glass transition temperature (Tg) from 75°C to 31°C. Electrochemical Impedance Spectroscopy shows that doping influences charge transfer processes, rendering the material semi‐conducting, as evidenced by decreased conductance when adding silver nanoparticles to PU6. Notably, protein adsorption studies reveal that undoped PU6 displays superior protein resistance compared to its doped counterpart, with fibrinogen exhibiting a higher adsorption affinity than BSA. The study discusses a plausible mechanism underlying protein adsorption.
Synthesis and mechanism study of an environmentally friendly filtrate reducing agent from humic acid and organic silicon
Authors: Song Bingqian , Du Weichao , Dong Haiyan , Gao Shifeng , Qu Yuanzhi , Wang Ren , Zhang Zhilei , Ren Han 
Published: December 2023

AbstractIn this study, organic silicon was introduced to humic acid for the first time, and set the novel polymer NaHm/AMPS/AM/TSP‐L12 (HASSi) as an environmentally friendly filtrate reducing agent, which was developed by using silica modified material (TSP‐L12), sodium humic acid (NaHm), 2‐acrylamido‐2‐methylpropanesulfonic acid sodium (AMPS), and acrylamide (AM) as raw materials. The molecular structure, chemical composition of HASSi has been investigated and results show that HASSi shows the chemical structure was conformed to the molecular design. Differential scanning calorimetry–thermogravimetric analysis results illustrate that thermal decomposition temperature of HASSi under nitrogen was 250°C. Though temperature resistance evaluations, HASSi could withstand temperature up to 230°C. Salt and calcium resistance evaluations confirmed its resistance of NaCl could reach up to 5% and CaCl2 to 0.5%. The filtrate reduce mechanism of HASSi was investigated through various methods, including scanning electron microscope analysis of HASSi aqueous solution, microstructure of filter cake, measurements of zeta potential, and particle size distribution, results showed that HASSi participation in the formation of mud cakes and illustrated an excellent filtration reduction effect. In addition, HASSi was identified as an environmentally friendly filter loss reducing agent through environmental performance evaluation, which shows a great application prospect in oilfield.
Enhancement of the hydrophobicity and oleophobicity of a polyurethane coating using a fluorine‐free polyfarnesene‐based polyol
Authors: Shiraki Yoshihiko 
Published: December 2023

AbstractThe development of hydrophobic and oleophobic surfaces on materials has attracted significant attention in various research fields. Fluoropolymers, which possess low surface energy and are both highly hydrophobic and oleophobic in nature, are widely used to enhance the liquid repellency of materials. However, during fluoropolymer manufacture, fluorine‐containing compounds are released into the environment; thus, alternatives to fluoropolymers are required for maintaining environmental safety and realizing a sustainable society. Notably, the development of such alternative materials has been limited. Thus, we herein report the application of a novel polyurethane (PU) coating synthesized from bio‐based raw materials. The prepared hydrogenated polyfarnesene PU (HHPF PU), which possesses an amorphous bottlebrush‐like polyalkyl structure, was found to exhibit higher hydrophobicity and oleophobicity than polytetrafluoroethylene (PTFE), which is a typical low‐surface‐energy material. The water and n‐hexadecane contact angles of the HHPF PU were determined to be 119° and 68°, respectively, whereas those of PTFE were 108° and 46°, respectively. In addition, the density depth profile of the PU thin film was confirmed through x‐ray reflectometry. This study provides a novel approach for enhancing the hydrophobicity and oleophobicity of materials using bottlebrush‐like polyalkyl structure instead of fluorine.
Effect of cyanide content on the tribological performance of nitrile butadiene rubber
Authors: Wei Peng , Liu Qingkun , Hou Xin , Zhou Qiong , Bai Pengpeng , Meng Yonggang , Ma Liran , Tian Yu 
Published: December 2023

AbstractNitrile butadiene rubber (NBR) has received a lot of attention as a sealing material, and its tribological performance is a crucial factor in determining the efficiency with which it will operate under various operating situations. In this study, NBR specimens with varying degrees of cyanide content, namely low cyanide (DN401), medium cyanide (DN2850), medium‐high cyanide (DN3380), and high cyanide (DN4050), were selected to investigate their tribological behavior when subjected to NO.10 aviation oil. To emulate their frictional responses during startup and shutdown operations, all four types of NBR were assessed under dry conditions. As the cyanide content increased, the coefficient of friction (COF) dropped from 1.381 to 0.810 and wear rate dropped from 2.38 × 10−3 mm3/(N m) to 1.88 × 10−4 mm3/(N m). When employed in conjunction with NO.10 aviation oil, DN401 and DN3380 exhibited COFs of 0.0963 and a slightly higher value of 0.127, respectively. Following aging treatment at 80°C in NO.10 aviation oil, stress reduction reached 65.8%, indicating the poorest performance among the four variants of NBR. Considering the COF, wear rate, and aging performance, DN3380 emerges as the most favorable choice for practical applications, thereby offering valuable insights into the selection of nitrile rubber for sealing materials.
Preparation and characterization of quaternary bacterial cellulose composites for antimicrobial oil‐absorbing materials
Authors: Men Ying , Yang Ruiting , Yang Xubing , Qin Ziyu , Yin Xueqiong 
Published: December 2023

AbstractThe treatment of various types of oily wastewater is paramount for environmental protection. Bacterial cellulose (BC) stands out as a highly promising material for oil/water separation, owing to its exceptional mechanical properties and three‐dimensional porous structures. However, excessive hydroxyl groups on BC make it highly hydrophilic, reducing oil absorption and promoting bacterial growth, affecting its stability. To address these challenges, we developed a straightforward in situ polymerization method for the preparation of BC‐DMC composites. The innovation lies in the concurrent enhancement of BC's hydrophobicity and antimicrobial properties only through the addition of 2‐(Methacryloyloxy)ethyltrimethylammonium chloride (DMC), considerably simplifying the synthesis of materials possessing oil‐absorbing and antimicrobial properties. Morphological and structural characterization results confirmed the successful combination of DMC onto BC while maintaining its porous structure. After process parameter optimization, the BC‐DMC composites exhibited a remarkable increase in contact angle (117.7° compared with pure BC's 19.5°). It also demonstrated excellent oil absorption performance, with maximum capacities exceeding 30 g/g for different oils, maintaining values above 20 g/g even after eight cycles. In addition, the BC‐DMC composites exhibited strong antibacterial activity, with rates of 82.4% against Escherichia coli and 97.5% against Staphylococcus aureus. The antibacterial mechanism of the BC‐DMC composites was also discussed. Our novel BC‐DMC composites provides excellent oil absorption and antibacterial properties, making it highly applicable in the field of oily wastewater treatment and serving as a valuable reference for other researchers.
Clinical Features and Immunogenetic Risk Factors Associated With Additional Autoantibodies in Anti‐Transcriptional Intermediary Factor 1γ Juvenile‐Onset Dermatomyositis
Authors: Sherman Matthew A. , Yang Qingyuan , Gutierrez‐Alamillo Laura , Pak Katherine , Flegel Willy A. , Mammen Andrew L. , Rider Lisa G. , Casciola‐Rosen Livia A. ,   for the Childhood Myositis Heterogeneity Collaborative Study Group
Published: December 2023

ObjectiveNovel autoantibody specificities including anti‐CCAR1 were recently discovered in adult patients with anti‐transcriptional intermediary factor (TIF1)–positive dermatomyositis (DM) and were associated with attenuated cancer emergence. The aims of the present study were to examine whether these autoantibodies occur in patients with juvenile‐onset DM (JDM) and to determine their associated features.MethodsSera from 150 patients with anti‐TIF1γ autoantibody‐positive JDM in a cross‐sectional cohort and 90 juvenile healthy controls were assayed for anti‐CCAR1, anti‐C1Z1, anti‐IMMT, anti‐TBL1XR1, and anti‐Sp4 autoantibodies. Demographics, myositis autoantibodies, clinical features, medications, outcomes, and HLA‐DRB1 and HLA‐DQA1 alleles were compared between those with and without these autoantibodies.ResultsAny one of the anti‐TIF1γ‐associated autoantibodies was present in 44 patients (29%) overall, including 25 (17%) with anti‐Sp4, 22 (15%) with anti‐TBL1XR1, 14 (9%) with anti‐CCAR1, 2 (1%) with anti‐C1Z1, and 2 (1%) with anti‐IMMT autoantibodies. These anti‐TIF1γ‐associated autoantibodies frequently co‐occurred. Patients with any of the anti‐TIF1γ‐associated autoantibodies had less frequent falling (34% [15] vs. 53% [56], P = 0.032) and lower peak muscle enzymes. None of the patients had cancer. Among White patients, HLA‐DRB1*03 was protective against an anti‐TIF1γ‐associated autoantibody (odds ratio 0.20, 95% confidence interval 0.07–0.52).ConclusionAutoantibodies associated with anti‐TIF1γ were found in isolation and in combination among a subset of patients with JDM. Patients with these autoantibodies had less severe muscle disease and were not enriched for HLA‐DRB1*03. Additional autoantibodies among patients with positive anti‐TIF1γ with JDM likely contribute to the heterogeneity of the anti‐TIF1γ serologic subgroup.
Rapid Analysis of Trace Amounts of Amino Acid Derivatives by a Formyl Group‐Installed Crystalline Sponge
Authors: Zhou Boyu , Utjapimuk Soravit , Yan KaKing , Dubey Ritesh , Kikuchi Takashi , Mitsuhashi Takaaki , Fujita Makoto 
Published: December 2023

AbstractThe Industries need techniques for the rapid structure analysis of amino acid derivatives. The amino acid derivatives are sometimes produced as impurities in the industrial production processes, and cause toxicity problems. Herein, we report the crystalline sponge (CS) method analysis of variety of amino acids using a formyl group installed CS crystal. Most amino acids possess a primary amino group, which can form Schiff‐base with the formyl group under mild conditions. Thus, the formyl group installed CS crystal can efficiently capture the amino acids via Schiff‐base formation. We successfully analyzed derivatives of 18 proteogenic amino acids, 6 non‐proteogenic amino acids, and 4 dipeptides using the formyl group installed CS. We thus believe that the protocols shown in this study would serve the need of the industries.