bluuebunny/crossref_metadata_2025_split huggingface dataset:
THE MODIFIED NORWOOD PROCEDURE FOR HYPOPLASTIC LEFT HEART SYNDROME: FIRST EXPERINCE OF USING THE «KEMANGIOPROTEZ» VASCULAR XENOGRAFT
Authors: Halivopulo Ivan K. , Troshkinev Nikita M. , Shabaev Ilmir F. , Borisenko Dmitry V. , Lyapin Anton A. , Evtushenko Alexey V. , Barbarash Leonid S. 
Published: October 2023

HighlightsThe article presents a unique clinical case of correction of hypoplastic left heart syndrome with Norwood procedure using a “KemAngioprosthesis” vascular xenograft as a Sano shunt. AbstractWe present the first successful clinical case of using the “KemAngioprosthesis” vascular xenograft in the pulmonary position as the Sano shunt in the Norwood procedure for correction of hypoplastic left heart syndrome. A newborn baby (gestation period of 38 weeks) diagnosed with congenital heart disease, and hypoplastic left heart syndrome was admitted to the Research Institute for Complex Issues of Cardiovascular Diseases. The child survived the first stage of the modified Norwood procedure (Sano shunt) using a biological vascular prosthesis. This clinical case showed that using the “KemAngioprosthesis” vascular xenograft in Norwood procedure to modify pulmonary blood flow by creating an anastomosis between the right ventricle and bifurcation of the pulmonary artery is effective and safe in the short-term period.
N-GLYCOLYLNEURAMINIC ACID AS A POSSIBLE TRIGGER FOR IMMUNE REJECTION OF EPOXY-TREATED XENO-PERICARDIAL HEART VALVE BIOPROSTHESES
Authors: Kostyunin Alexander E. , Glushkova Tatiana V. , Rezvova Maria A. , Klyshnikov Kirill Yu. , Onishchenko Pavel S. , Ovcharenko Evgeny A. 
Published: October 2023

HighlightsStabilization of bovine pericardial tissue by ethylene glycol diglycidyl ether does not remove the N-glycolylneuraminic acid contained in its structure, which is one of the most immunoreactive glycan xenoantigens;N-glycolylneuraminic acid can potentially cause early immune rejection of epoxy-treated bioprosthetic heart valves. Aim. To assess the presence of N-glycolylneuraminic acid (Neu5Gc) in an intact bovine pericardial tissue stabilized by ethylene glycol diglycidyl ether and in the leaflets of epoxy-treated bioprosthetic heart valves (BHV) explanted due to dysfunction.Methods. By means of immunochemistry (using anti-Neu5Gc antibodies), we studied the fragments of 5 samples of intact epoxy-treated bovine pericardium commonly used in cardiac surgery. Similarly, we examined the fragments of the leaflets of 8 epoxy-treated BHVs that lasted for different time periods (1 day to 68 months) and excised during reoperation. The native bovine pericardium and the leaflets of 3 human aortic valves (AV) removed during reoperation in patients with aortic stenosis were used as positive and negative controls, respectively.Results. Positive reaction for Neu5Gc was observed in intact epoxy-treated xenopericardium and BHVs excised 1, 2, 20 and 42 days after implantation. The tissue of BHV that had lasted 30 months was characterized by the faint presence of Neu5Gc. In the leaflets of AV and in BHVs, explanted after 34, 63 and 68 months, Neu5Gc was not detected. Conclusion. Stabilization of xenobiomaterial with ethylene glycol diglycidyl ether does not remove the Neu5Gc. This saccharide remains in the biological tissue of epoxy-treated BHV for about 2.5 years after implantation.
HEALTH AND DEMOGRAPHIC SITUATION IN MOSCOW AND RUSSIAN FEDERATION DURING THE COVID-19 PANDEMIC
Authors: Kalininskaya Aleftina A. , Schepin Vladimir O. , Lazarev Andrey V. , Kizeev Mikhail V. , Shlyafer Sofia I. 
Published: October 2023

Highlights Higher rates of COVID-19 morbidity and mortality compared to Russia as a whole were noted in Moscow during the COVID-19 pandemic and after it (2020-2021). We have reached the conclusion that it is necessary to develop regional prevention and rehabilitation approaches for COVID patients. Aim. To analyze health and demographic indicators of Moscow, Russia and its constituent entities in the context of the COVID-19 pandemic to develop regional prevention, management and rehabilitation programs for COVID patients.Methods. The study incorporated statistical, analytical, and observational methods. The data of the Federal State Statistics Service, and reports of the Central Research Institute of Healthcare of the Ministry of Health of Russia for 2012–2022 were used for the analysis.Results. General morbidity of the population in Moscow (2021) amounted to 148 906.0 per 100 000 population. The highest rates were noted in the following classes of diseases: diseases of the respiratory system, circulatory system, diseases of the musculoskeletal and connective tissue, genitourinary system, etc. In the Russian Federation, the overall incidence rate in 2021 was 167 713.8‰00, which is 11.6 % higher compared to Moscow. In 2019 (before the COVID-19 pandemic) the frequency of primary morbidity in Moscow was 65 818.1‰00, in 2020 the frequency decreased to 63 204.4‰00, and in 2021 it increased to 71 523.9‰00, which is 8.7% higher than in 2019. Between 2019 and 2021, there was an increase in primary morbidity rates in the following classes of diseases in Moscow: mental and behavioral disorders by 12.1%, diseases of the blood, hematopoietic organs and disorders involving the immune mechanism – by 5.3%, diseases of the nervous system – by 2.1%, etc., which indicates the need for rehabilitation of patients with this pathology. In 2021 the incidence rate of COVID-19 in Moscow increased to 8 976.0‰00, in the Russian Federation the incidence rate was lower – 8 085.7‰00. The difference in indicators between the constituent entities of the Russian Federation is quite high and amounts to 11.8. The pandemic has exacerbated the demographic situation in Russia. Mortality rates (for 2019–2021) increased in the Russian Federation from 12.3‰ to 13.6, and in Moscow the increase was more significant – from 9.5 to 16.7‰. The results of the analysis indicate the need to improve preventive and management programs for COVID patients, even more so in Moscow. In Moscow and Russian Federation as a whole higher rate of general morbidity in children and adolescents compared to total and adult population morbidity over 10 years (2012–2021) points to the importance of prevention and management programs of this population.Conclusion. The results of the study reaffirm the need to develop regional prevention, management and rehabilitation approaches for COVID patients.
RELATIONSHIP BETWEEN BIOMOLECULES ASSOCIATED WITH THE SECRETORY ACTIVITY OF VISCERAL ADIPOCYTES AND ELECTROPHYSIOLOGICAL SIGNS OF METABOLIC CARDIOMYOPATHIES IN PERSONS UNDER 45 YEARS OF AGE
Authors: Kuzminykh Natalia A. , Shcherbakova Lilia V. , Kashtanova Elena V. , Polonskaya Yana V. , Shramko Victoria S. , Garbuzova Evgeniya V. , Ragino Yulia I. 
Published: October 2023

Highlights ECG signs of metabolic cardiomyopathies in men aged 25–44 years, regardless of age and waist circumference, are directly associated with the serum adipsin concentration and inversely associated with the concentration of glucagon-like peptide 1 in the blood.ECG signs of metabolic cardiomyopathies in women aged 25–44 years are directly associated with the serum c-peptide concentration and inversely associated with the concentration of glucose-dependent insulinotropic polypeptide 1 in the blood. AbstractAim. To study the relationship between electrophysiological signs of metabolic cardiomyopathy (MC) and biomolecules associated with the secretory activity of visceral adipocytes in persons aged 25–44 years residing in Novosibirsk.Methods. The study included 1 198 subjects. A single-stage survey of a random sample of the 25–44-year-old population of Novosibirsk (49,7% men, 50,3% women) was conducted. During the examination, among other things, a resting 12-lead ECGs was recorded, and later the ECGs were classified according to Minnesota Code categories. Five ECG signs of MC were analysed: 1) ST-segment displaced above baseline (ST-segment elevation); 2) ST-segment displaced below baseline (ST-segment depression); 3) T wave changes; 4) TV1>TV6 patterns and 5) ECG signs of left ventricular hypertrophy. Serum concentrations of biomolecules associated with the secretory activity of visceral adipocytes were determined by multiplex analysis.Results. The results of multivariate logistic regression analysis showed that the ECG signs of MC in men aged 25–44 years, regardless of age and waist circumference, are directly associated with the serum adipsin concentration (Exp B 1,039, 95% CI 1,002–1,077, p = 0.039) and inversely associated with the concentration of glucagon-like peptide 1 in the blood (Exp B 0.999, 95% CI 0.998–1,000, p = 0.042). ECG signs of MC in women aged 25–44 years are directly associated with the serum peptide concentration (Exp B 1,439, 95% CI 1,082–1,915, p = 0.012) and inversely associated with the concentration of glucose-dependent insulinotropic polypeptide in the blood (Exp B 0.986, 95% CI 0.978–0.995, p = 0.001).Conclusion. The results obtained reflect the significant influence of these biomolecules associated with the secretory activity of visceral adipocytes on the occurrence of ECG signs of MC in young people aged 25–44 years.
ANALYSIS OF THE MORTALITY RATE DYNAMICS DUE TO CIRCULATORY SYSTEM DISEASES IN THE KEMEROVO REGION FOR THE PERIOD 2017-2021.
Authors: Tsygankova Darya P. , Agienko Alena S. , Sedykh Darya Yu. , Makarov Sergey A. , Artamonova Galina V. 
Published: October 2023

HighlightsEvery year more than 4 million deaths are registered from cardiovascular diseases (CVD), which is 46% of all deaths. Over the past 40 years, a downward trend in mortality from CVD has been revealed. However, the COVID-19 pandemic period has changed the statistics of indicators of both total mortality and mortality from CVD. Aim. To analyze the mortality rate (MR) features from CVD in the Kemerovo Region (KR) from 2017 to 2021, in comparison with the Russian Federation (RF) rate.Materials and Methods. Mortality rates of the adult population of KR and RF for the period 2017–2021 were taken from the official sources. The KR/RF dynamics was approximated by a linear trend using Microsoft Excel 2010.Results. Over the past 5 years (from 2017 to 2021) the increase in mortality from CVD was 58.2% in the KR and in the RF – 9%. In 2017 the mortality rates in the RF were higher than in the KR and they levelled off by 2018. However, in the period 2019-2021 there was a sharp increase rate in the KR, in comparison with the RF. According to Kemerovo Statistical Office, the mortality rate from CVD in the region in 2021 was 10.8% higher than in 2020. The structure of mortality from CVD in 2021 in the KR had 52.8% of death cases due to coronary heart disease and 32.6% were caused by the cerebrovascular disease. During the COVID-19 pandemic (2019–2021) the first 3 places among the causes of total mortality in the KR were occupied by CVD (46.3% – 49.4% – 49.3%, respectively), neoplasms (17.1% – 15.2% – 13.2%) and external causes of death (9% – 7.7% – 6.5%). In the structure of total mortality cases the COVID-19 share is 2% in 2020 and 6.4% in 2021, respectively, which raised them to the 4th place in 2021.Conclusion. An increase in mortality rates in the region may indicate both the real causes of death, they can also be associated with the peculiarities the death cases coding and the impact of clinical and organizational technologies as well as the aging of the population. All the data require further in-depth research.
Las mujeres que vuelan: género y cambio cultural en Cuetzalan
Authors: Rodríguez Blanco Eugenia 
Published: October 2023

El presente artículo propone un análisis feminista sobre las dinámicas del cambio cultural en con textos indígenas. Procuramos documentar el proceso seguido por los cambios relativos a la superación de la exclusión o marginación de las mujeres, y analizar los factores que los causaron. En este estudio buscamos datos que puedan probar si tales cambios son consecuencia de una transformación en las relaciones de género —y de un aumento del empoderamiento de las mujeres—, o si son resultado de otros factores e intereses que tienen como efecto secundario una reducción de la marginación femenina. El caso que presentamos aquí es el de la participación de mujeres en la danza de los voladores, un fenómeno reciente que sugiere un cambio cultural vinculado al género.AbstractThis article puts forward a feminist analysis of the dynamics of cultural change in indigenous contexts. We intend to document the processes of cultural change that are concomitant to overcoming exclusion or marginalization of women, and to analyze the factors that cause such transformations. In this study we look for signs that can prove whether these changes are a consequence of a transformation in the gender relations — and an increase in the empowerment of women—or if they are the result of other factors and interests which have the secondary effect of reducing the marginalization of women. The specific case presented here is the participation of women in the "danza de los voladores", a recent phenomenon that suggests a cultural change in relation to gender.
Modern nematode-resistant varieties of potatoes in the conditions of the North
Authors: Zhigadlo T. E. 
Published: October 2023

Golden potato nematole (Globodera rostochiensis Woll.) is a phytoparasite, a microscopic worm that causes potato globoderosis. As a result, the yield is sharply reduced, small tubers are formed, and then the complete death of plants. The damage caused by the golden potato nematode manifests itself when the soil is infected with larvae in the amount of 1 thousand pieces or more in 100 cm3. The decrease in yield in areas of severe infection can reach from 70 to 90%. Early potato varieties are most affected. The best way to protect potato varieties from globoderosis is to use in the production of varieties resistant to golden potato nematode. The aim of the research was to study nematode-resistant potato varieties in the Murmansk region.Methods. In 2016-2020, 49 potato varieties resistant to globoderosis were studied on the experimental field of the Polar Experimental Station of VIR according to the main biological and economically valuable characteristics. The size of the plot was 0,05 ha, the area of plant nutrition was 70x30 cm. Planting of varieties was carried out in early June. The samples were planted in the field in a row of 10 plants of each variety. Every 10 samples, the Khibinskiy ranniy variety was located. All accounts are performed according to the VIR methodology.Results. Phenological observations have shown varieties with short periods of passage of phenological phases: Diamond, Grand, Pershatsvet, Khibinskiy ranniy, Roeslau. Berry formation was of the Labadia variety. The yield on the 60th day from planting was 531.7-741.7 g / bush (the maximum yield of the Madeleine variety). On the 90th day from planting, the yield of the varieties was in the range of 747,5-1153,0 g/bush (the maximum for the Eurasia variety). Starch content varied from 8,3% (Arrow grade) up to 20,4% (Albatros). According to disease resistance, the varieties Grand, Gusar, Eurasia, Harmony, Colorit, Rasinka, Albatros, Angela, Courage are distinguished. Conclusion. Samples of the world potato collection have been studied; sources of valuable traits that can be used in breeding work to create new varieties suitable for cultivation in the Far North have been identified.
Peculiarities of ex vitro growing completion of bog cranberry (Vaccinium oxycoccos L.) with a closed root system
Authors: Nechiporenko I. V. , Akimova S. V. , Kazakov P. O. 
Published: October 2023

Timeliness.The prerequisites for the cultivation of bog cranberry (Vaccinium oxycoccosL.) in industrial plantations have led to an increased demand for high quality planting material obtained by clonal micropropagation (in vitro). Studies have been carried out on the ofex vitrogrowing completion of cranberry plants using different mineral fertilizers and types of light under greenhouse conditions.Methods.Ex vitroplants of a selected form of cranberry (Vaccinium oxycoccosL.) obtained using the clonal micropropagation technique were the objects of research. Experimental adapted cranberry plants were planted in 0.5 L containers in 'Veltorf' peat substrate with an acidity of at least pH 3.5-4.0, to which mineral fertilizers were added according to the variants: APAVIVA N15P15K15(S10) 0.08 and 0.16 g/L, Sulfoammophos N16P20(S12) 0.072 and 0.144 g/L, N12P52 0.1 and 0.2 g/L, control without fertilizer. The plants were placed under different types of light: under LED phytolamps (UnionPowerStar – 40W-T) with a photoperiod of 16 hours and under natural light (without the use of additional lighting) under greenhouse conditions.Results. It was found that during of theex vitrogrowing completion of bog cranberry (Vaccinium oxycoccosL.) plants in containers, the advantage of LED phytolamps was revealed, when using them in all experimental variants on the 42nd day of growing the morphometric indicators of plant development were almost 2 times higher than in plants grown under natural light. The type of mineral fertilizers and type light significantly influenced the total length of shoots (82.9±13.74- 107.4±35.95 cm vs. 58.6±20.92 cm in control) and leaf surface area (41.1±6.46-54.1±4.67 cm2 vs. 22.9±9.63 cm2 ).Conclusion.The results we obtained contributed to a better representation of theex vitrogrowing conditions of bog cranberry (Vaccinium oxycoccosL.) plants using different types of lighting (phyto-lighting with a 16-hour photoperiod and natural light – without adding additional light) and the selection of optimal doses of mineral nutrition. The best, under LED lighting, were N16P20(S12) at a concentration of 0.072 g/L and N15P15K15(S10) at a concentration of 0.16 g/L.
La invención de los celos
Authors: Konstan David 
Published: October 2023

En este artículo propongo la idea de que, en la Grecia clásica, no existía el concepto de un sentimiento que corresponda precisamente al de los celos en el mundo occidental moderno. Investigo el significado de la palabra zélotupia, que con frecuencia se traduce por "celos", y demuestro que no tenía exactamente este sentido en los textos griegos antiguos. Sin embargo, si había poco espacio en la cultura de la Grecia arcaica para el desarrollo de la idea de celos en el sentido romántico, en Roma en el siglo primero a.C. las condiciones favorecían la formación de tal concepto, concretamente en la poesía amatoria de Horacio y los autores de la elegía erótica.
Maintaining Political Rights Equality
Authors: Widaningtyas Adoniati Meyria , Darojat Windu 
Published: October 2023

Most of the blind in Indonesia live in vulnerable, underdeveloped and poor conditions due to restrictions, barriers, difficulties, and reduction or elimination of the rights of disabilities. In Indonesia there are 3.5 million blind people. Of the existing number, 80% already have the right to vote in the 2019 elections. However, blind people have not been able to carry out elections in accordance with the principles of LUBER, Honest and Fair. They must get assistance from other parties or people in casting their votes at the TPS. This is prone to fraud, manipulation and leakage of options. RASA MESRA innovation is a ballot template that helps the blind in punching ballots without the need for assistance from other people. RASA MESRA is designed to be easily oriented by blind people. The button provided on RASA MESRA will provide an audio explanation according to the writing on the ballot papers. With the existence of RASA MESRA, people with blind sensory disabilities can be independent in determining their voting rights, reduce fraud and manipulation of votes, and guarantee equal rights of persons with disabilities in accordance with the principles of LUBER, Honest and Fair. RASA MESRA was initiated by PPSDSN Penganthi Temanggung.
Keywords: blind people, disability, political rights, innovation, Rasa Mesra
RESPON ESTRUS PADA KAMBING PERANAKAN ETTAWA DENGAN BODY CONDITION SCORE 2 DAN 3 TERHADAP KOMBINASI IMPLANT CONTROLLED INTERNAL DRUG RELEASE JANGKA PENDEK DENGAN INJEKSI PROSTAGLANDIN F2 ALPHA
Authors: Dewi Ratri Ratna , W Wahyuningsih , Widayati Diah Tri 
Published: October 2023

Penelitian ini bertujuan mengetahui respon estrus pada kambing Peranakan Ettawa (PE) dengan Body Condition Score (BCS) 2 dan 3 terhadap implant Controlled Internal Drug Release (CIDR) jangka pendek dikombinasikan dengan injeksi prostaglandin F alpha (PGF a). Sebanyak 10 ekor kambing PE betina dibagi 2 2 dalam 2 kelompok perlakuan berdasarkan BCS, yaitu kelompok I dengan BCS 2 (kondisi kurus), berat badan antara 25-30 kg (n=5) dan kelompok II dengan BCS 3 (kondisi ideal) berat badan antara 35-40 kg (n=5). Semua kelompok perlakuan disinkronisasi dengan implant CIDR (berisi 1,3 g progesteron) secara intravaginal jangka pendek selama 10 hari dan 48 jam sebelum pencabutan CIDR, kambing diijeksi dengan PGF a. Deteksi estrus dilakukan setiap hari dengan interval 6 jam dimulai dari pencabutan CIDR sampai 60 2 jam setelah pencabutan CIDR. Data onset dan durasi estrus dianalisis menggunakan independent sample T-test sedangkan tanda-tanda visual estrus dianalisis secara deskriptif. Respon estrus semua kelompok perlakuan adalah 100%. Onset dan durasi estrus antara BCS 2 dan 3 masing-masing adalah 21,60±1,47 vs 13,20±1,20 jam dan 27,60±3,06 vs 32,40±1,47 jam. Dari hasil penelitian dapat disimpulkan bahwa kombinasi implant CIDR jangka pendek dan injeksi PGF a efektif untuk sinkronisasi estrus pada kambing PE dengan 2 BCS 2 dan 3.
IDENTIFIKASI PROTEIN EPIDERMAL GROWTH FACTOR (EGF) 46 kDa HASIL MATURASI OOSIT SAPI SECARA IN VITRO
Authors: W Widjiati , Rachmawati Anike , Mumpuni Sri , Sektiari Bambang 
Published: October 2023

Tujuan dari penelitian ini adalah mengidentifikasi suatu protein dengan berat molekul 46 kDa yang diduga sebagai epidermal growth factor (EGF) yang diisolasi dari oosit sapi yang telah dimaturasi secara in vitro dengan metode elektroforesis. Ovarium sapi yang berasal dari rumah potong hewan, diaspirasi pada folikel dengan diameter permukaan ≤5 mm menggunakan spuit dan jarum. Oosit dimaturasi dalam tissue culture medium (TCM) 199 selama 22 jam pada suhu 38,5° C di dalam inkubator CO2. Preparasi protein dengan berat molekul 46 kDa menggunakan sodium dodecyl sulphate polyacrilamide gel elektroforesis (SDS PAGE). Berdasarkan perhitungan jumlah regresi dari protein marker, didapatkan 12 fraksi protein yaitu BM 172,7; 153,09; 118,24; 102,43; 89,27; 59,75; 46,41; 43,82; 40,2; 36,06; 23,45; dan 18,42 kDa. Protein dengan berat molekul 46,41 kDa yang tampak pada pita protein dapat diidentifikasi sebagai protein yang diduga EGF yang berperan dalam proses maturasi oosit.
ASPEK PATOLOGIS INFEKSI PARVOVIRUS PADA ANAK ANJING DI KOTA DENPASAR
Authors: Bagus Oka Winaya Ida , Ketut Berata I , Mirah Adi AAA , Made Kardena I 
Published: October 2023

Telah dilakukan penelitian mengenai aspek patologis infeksi parvovirus pada anak anjing di Denpasar. Sebanyak 80 ekor anak anjing telah
diperiksa pada Laboratorium Patologi Fakultas Kedokteran Hewan Universitas Udayana periode tahun 2011- 2012. Enam belas ekor diantaranya
menunjukkan gejala klinis berak darah, depresi, anoreksia, dan dehidrasi. Sinyalemen mengenai umur, jenis kelamin, dan ras juga dicatat.
Perubahan patologi anatomi secara signifikan berupa enteritis haemorrhagis et necrotican dapat ditemukan pada semua anak anjing penderita.
Kongesti dan nekrosis ditemukan pada epikardium. Gambaran yang bersifat anemia ditemukan pada jaringan limpa, ginjal, hati, sedangkan paruparu mengalami hiperemia. Secara mikroskopis, pada usus halus mengalami hiperemia disertai dengan infiltrasi limfosit, villi terlihat atropi dan
nekrosis pada kripta Lieberkuhn. Nekrosis limfosit (limfositolisis) ditemukan pada folikel limpa. Kongesti dan nekrosis pada otot jantung namun
intranuclear inclusion bodies hanya ditemukan pada satu anak anjing penderita. Penebalan ditemukan pada septa alveoli sedangkan pada hati dan
ginjal hanya ditemukan peradangan ringan. Secara klinis bentuk enteritis hemorhagis et necrotican selalu ditemukan pada anak anjing terinfeksi
parvovirus di Kota Denpasar.
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