bluuebunny/crossref_metadata_2025_split huggingface dataset:
Adverse Events Associated with IL-23 Inhibitors in the Clinical Management of Psoriasis: A Comprehensive Pharmacovigilance Analysis
Authors: Shi Wentao , Zhai Yinghong , Zhao Ziyi , Ye Xiaofei , Xu Feng 
Published: November 2023

Abstract

Background
Interleukin-23 (IL-23) inhibitors constitute a pivotal class of therapeutic agents employed in the clinical management of Psoriasis, a chronic autoimmune skin disorder. Notwithstanding their therapeutic efficacy, concerns have arisen due to the emergence of multiple adverse events (AEs) associated with their usage. This study aims to provide a comprehensive examination of the distribution and characteristics of these AEs concerning IL-23 inhibitors, with a specific focus on Guselkumab, Tildrakizumab, Risankizumab, and Ustekinumab.
Methods
In this research endeavor, we conducted an extensive analysis of data extracted from the FDA Adverse Event Reporting System (FAERS), spanning the timeframe from January 1, 2014, to September 30, 2022. To identify potential signals of AEs, we rigorously applied disproportionality analysis, utilizing both reporting odds ratio (ROR) and information component (IC) metrics. A signal was considered present when the lower limit of the 95% confidence interval (CI) for ROR (ROR025) exceeded one or when IC (IC025) surpassed zero, with a minimum requirement of three or more reported cases.
Results
Our investigation encompassed a substantial dataset, comprising a total of 41,408,408 reports detailing drug-AE associations and involving 13,271,168 individuals. Among these, 704, 13,164, 62,853, and 11,399 patients were identified as users of Tildrakizumab, Guselkumab, Ustekinumab, and Risankizumab, respectively. The analysis revealed the presence of 8, 20, 107, and 115 signals for these respective drugs. Significantly, the System Organ Class (SOC) exhibiting the highest incidence was "infections and infestations," with documented occurrences in Tildrakizumab (6/8), Guselkumab (5/20), Ustekinumab (50/107), and Risankizumab (25/115).
Conclusion
Our pharmacovigilance analysis has brought to light a substantial frequency of AEs linked to IL-23 inhibitors. These findings underscore the pivotal role of IL-23 inhibitors in modulating immune function and raise concerns regarding their potential to heighten susceptibility to infections and malignancies. Of particular significance is Risankizumab, which, despite having fewer reported cases and a later market introduction compared to Ustekinumab, exhibited a higher incidence of AEs. These results emphasize the necessity for ongoing vigilance, further investigation, and a reevaluation of the safety profile of IL-23 inhibitors in the clinical management of Psoriasis.
The triglyceride glucose index trajectory is associated with hypertension: a retrospective longitudinal cohort study
Authors: Xin Fengling , He Shuyou , Zhou Yu , Jia Xueni , Zhao Yulong , Zhao Hui 
Published: November 2023

Abstract
Background Previous studies have found that the triglyceride glucose index (TyG index ) trajectories are associated with cardiovascular diseases. However, the association between the patterns of TyG index trajectories and risk for hypertension has not been investigated. In a longitudinal general population, we aimed to identify distinct TyG index trajectories over 12 years and describe their association with incidence of hypertension.
Method Of the 15,056 adults retrospectively recruited from the Physical Examination Center of the Second Affiliated Hospital of Dalian Medical University in northeast of China from 2011 to 2022. TyG index was calculated as The TyG index was measured ln (fasting TG [mg/dL] ×FPG [mg/dL]/2) and the TyG index trajectories were developed using group-based trajectory modelling. Cox regression analysis was accomplished to assess the association between TyG index and incidence of hypertension.
Results The median age of the population was 38 years, and 7,352 (48.83%) of the participants were men. Three distinct TyG index trajectories were identified: “low increasing” (N = 7,241), “moderate increasing” (N = 6,448), and “high stable” (N = 1,367). Using “low increasing” trajectory as a reference, “moderate increasing” and “high stable” trajectory were associated with increased risk of hypertension (HR = 2.45; 95%CI 2.25-2.67 and HR = 3.88; 95%CI 3.48-4.33). After adjusting for baseline sex, age, diabetes, smoking, systolic blood pressure, diastolic blood pressure, BMI, cholesterol, high density lipoprotein cholesterol, low density lipoprotein cholesterol, blood glucose, triglyceride, urea, uric acid, and glomerular filtration rate, the HR were slightly attenuate in “moderate increasing” and “high stable” trajectories to 1.38 (95%CI 1.23-1.54) and 1.69 (95%CI 1.40-2.02) respectively. Meanwhile, similar results were observed in multiple sensitivity analyses. The HR of the “moderate increasing” and “high stable” trajectory groups were 2.63 (95% CI 2.30-3.00) and 4.66 (95% CI 3.66-5.93) in female, and 1.66 (95% CI 1.48-1.86) and 2.33 (95% CI 2.04-2.66) in male.
Conclusions Elevated TyG index at baseline and long-term TyG index trajectories were associated with the risk of hypertension. Early identification of increasing TyG index could provide insights for preventing hypertension later in life.
Diffusion-weighted imaging of the dorsal root ganglion as a quantitative biomarker reflecting the severity and prognosis of herpes zoster：a prospective magnetic resonance imaging study
Authors: Shen Wang , Dai Gonghua , Liu Feng , Zhang Jinyuan , Fang Hong-Wei , Xu Wen , Zhang Wei , Yu Xiuqin , Fang Hong-Wei , Wang Xiangrui , Liao Lijun 
Published: November 2023

Abstract

This prospective study aimed to characterize diffusion-weighted imaging (DWI) of the dorsal root ganglion (DRG) in herpes zoster (HZ) and to investigate the apparent diffusion coefficient (ADC) as a quantitative evaluation indicator for HZ as well as a predictor for postherpetic neuralgia (PHN). Thirty-six patients with HZ and ten healthy volunteers underwent magnetic resonance imaging (MRI) scanning. The ADC values of the affected and symmetric asymptomatic DRG were collected and compared. The rash intensity (RI), visual analog scale (VAS), pain index (PI), insomnia severity index (ISI), self-rated anxiety scale (SAS) and self-rated depression scale (SDS) were used to assess clinical characteristics. DWI analysis showed that ADC values of symptomatic DRG were significantly lower than those of symmetric asymptomatic DRG in both the HZ-period (P < 0.001) and the follow-up period (P < 0.001). The ADC value difference of the bilateral DRG at the affected segment (asymptomatic value – symptomatic value) was correlated with several clinical data in the HZ period. Analysis of the receiver operating characteristic curve revealed that the HZ-period ADC value difference had a high predictive value for PHN (Area under the curve = 0.815, P = 0.003). The cutoff value was 0.121 × 10–3mm2/s. DWI of the DRG can quantitatively display the change in the affected DRG in HZ patients and may indicate nerve necrosis and structural variation of the neuronal cell membrane. DWI of the DRG can help evaluate the clinical status of patients with HZ and may be a potential prognostic indicator for the occurrence of PHN.
Optimising surgical anastomosis in ileocolic resection for Crohn's disease with respect to recurrence and functionality: Two international parallel randomized controlled trials comparing handsewn (end-to-end or Kono-S) to stapled anastomosis (HAND2END and the End2End STUDIES).
Authors: Haanappel Anouck , Bellato Vittoria , Buskens Christianne J , Armuzzi Alessandro , Bilt Jarmilla D W van der , de Boer Nanne K H , Danese Silvio , de Willeboi Eline M L van der Does , Duijvestein Marjolijn Duijveste , Horst Danielle van der , Pellino Gianluca , Richir Milan C , Selvaggi Francesco , Spinelli Antonino , Vignali Andrea , Rosati Riccardo , Bemelman Willem A 
Published: November 2023

Abstract

BackgroundThe most common intestinal operation in Crohn’s disease (CD) is an ileocolic resection. Despite optimal surgical and medical management, recurrent disease after surgery is common. Different types of anastomoses with respect to configuration and construction can be made after resection for example, handsewn (end-to-end and Kono-S) and stapled (side-to-side). The various types of anastomoses might affect endoscopic recurrence and its assessment, the functional outcome, and costs. The objective of the present study is to compare the three types of anastomoses with respect to endoscopic recurrence at 6 months, gastrointestinal function, and health care consumption.MethodsThis is a randomized controlled multicentre superiority trial, allocating patients either to side-to-side stapled anastomosis as advised in current guidelines or a handsewn anastomoses (an end-to-end or Kono-S). It is hypothesized that handsewn anastomoses do better than stapled, and end-to-end perform better than the saccular Kono-S. Two international studies with a similar setup will be conducted mainly in the Netherlands (End2End) and Italy (HAND2END). Patients diagnosed with CD, aged over 16 years in the Netherlands and 18 years in Italy requiring (re)resection of the (neo)terminal ileum are eligible. The first part of the study compares the two handsewn anastomoses with the stapled anastomosis. To detect a clinically relevant difference of 25% in endoscopic recurrence, a total of 165 patients will be needed in the Netherlands and 189 patients in Italy. Primary outcome is postoperative endoscopic recurrence (defined as Rutgeerts score ≥ i2b) at 6 months. Secondary outcomes are postoperative morbidity, gastrointestinal function, quality of life (QoL) and costs.DiscussionThe research question addresses a knowledge gap within the general practice elucidating which type of anastomosis is superior in terms of endoscopic and clinical recurrence, functionality, QoL and health care consumption. The results of the proposed study might change current practice in contrast to what is advised by the guidelines.Trial registration:NCT05246917 for HAND2END and NCT05578235 for End2End (http://www.clinicaltrials.gov/) Anouck Haanappel and Vittoria Bellato are shared first authors
Composite Exponential Potential Multistable Stochastic Resonance System in Weak Signal Detection
Authors: Wang Shuo , Zhang Mingwang , Yuan Yu 
Published: November 2023

Abstract
Based on the classical bistable system model and the Gaussian Potential model, a new composite exponential potential multistable stochastic resonance system (CEMSR system) is proposed to address the issue that it proves difficult to extract weak signals from conventional stochastic resonance systems under a strong noise background. First, enhancing the Gaussian Potential model creates a multistable stochastic resonance system model with a complex power index function. To confirm the impact of noise intensity on the system, the system is numerically solved using the fourth-order Runge-Kutta algorithm. Second, the system parameters are adjusted using the quadratic sampling technique, and the output signal-to-noise ratio (SNR) is employed as the fitness function of the particle swarm optimization process. The suggested model is compared to the system output of two compound tri-stable models by signal simulation and experimental verification, and it is demonstrated that the proposed model performs better at weak signal detection under the condition of fewer system parameters.
Advances in the Development of Carbonic Anhydrase Inhibitors as New Antiprotozoal Agents
Authors: Ortiz-Perez Eyra , Vazquez-Jimenez Lenci K. , Paz-Gonzalez Alma D. , Delgado-Maldonado Timoteo , González-González Alonzo , Gaona-Lopez Carlos , Moreno-Herrera Antonio , Vazquez Karina , Rivera Gildardo 
Published: November 2023

Background:
Parasitic diseases are a public health problem despite the existence
of drugs for their treatment. These treatments have variable efficacy and, in some
cases, serious adverse effects. There has been interest in the enzyme carbonic anhydrase
(CA) in the last two decades since it is essential in the life cycle of various parasites due to
its important participation in processes such as pyrimidine synthesis, HCO3
- transport
across cell membranes, and the maintenance of intracellular pH and ion transport (Na+,
K+, and H+), among others.

Objective:
In this review, CA was analyzed as a pharmacological target in etiological
agents of malaria, American trypanosomiasis, leishmaniasis, amoebiasis, and trichomoniasis.
The CA inhibitors´ design, binding mode, and structure-activity relationship are also
discussed.

Conclusion:
According to this review, advances in discovering compounds with potent
inhibitory activity suggest that CA is a candidate for developing new antiprotozoal agents.
Taxonomic Status and Phylogenetic Relationship of the Charadriidae
Family Based on Complete Mitogenomes
Authors: Qian Weiya , Liu Yizheng , Miao Keer , Chang Qing , Hu Chaochao 
Published: November 2023

Background:
The Charadriiformes provide a good source for researching evolution owing
to their diverse distribution, behavior, morphology, and ecology. However, in the Charadrii,
family-level relationships remain understudied, and the monophyly of Charadriidae is also a subject
of controversy.

Methods:
In the present study, we generated complete mitogenomes for two species, Charadrius
leschenaultii and Charadrius mongolus, which were found to be 16,905 bp and 16,844 bp in length,
respectively. Among the 13 protein codon genes, we observed variation in the rate of nonsynonymous
substitution rates, with the slowest rate found in COI and the fastest rate observed in
ATP8. The Ka/Ks ratio for all Charadriidae species was significantly lower than one, which inferred
that the protein-coding genes underwent purifying selection.

Results:
Phylogenetic analysis based on the genes of Cyt b, 12S and ND2 revealed that the genus
Pluvialis is the sister group of three families (Haematopodidae, Ibidorhynchidae, Recurvirostridae).
However, the phylogenetic analysis based on complete mitogenomes indicated that the genus Pluvialis
is within the Charadriidae family.

Conclusion:
This study highlights the importance of carefully selecting the number of genes used to
obtain accurate estimates of the species tree. It also suggests that relying on partial mtDNA genes with
fast-evolving rates may lead to misleading results when resolving the Pluvialis sister group. Future research
should focus on sequencing more mitogenomes at different taxonomic levels to gain a better
understanding of the features and phylogenetic relationships within the Charadriiformes order.
Recent Development in the Search for Epidermal Growth Factor
Receptor (EGFR) Inhibitors based on the Indole Pharmacophore
Authors: Mishra Shweta , Sahu Adarsh , Kaur Avneet , Kaur Maninder , Kumar Jayendra , Wal Pranay 
Published: November 2023

Abstract:
The signal transduction and cell proliferation are regulated by the epidermal growth
factor receptor. The proliferation of tumor cells, apoptosis, invasion, and angiogenesis is inhibited
by the epidermal growth factor receptor. Thus, breast cancer, non-small cell lung cancer, cervical
cancer, glioma, and bladder cancer can be treated by targeting the epidermal growth factor
receptor. Although third-generation epidermal growth factor receptor inhibitors are potent drugs,
patients exhibit drug resistance after treatment. Thus, the search for new drugs is being continued.
Among the different potent epidermal growth factor receptor inhibitors, we have reviewed the
indole-based inhibitors. We have discussed the structure-activity relationship of the compounds
with the active sites of the epidermal growth factor receptor receptors, their synthesis, and
molecular docking studies.
Correlation of MRI Findings with ODI and VAS Score in Patients with Lower Back Pain
Authors: Vučković Suada Hasanović , Vegar-Zubović Sandra , Milišić Lejla , Kristić Spomenka , Beganović Adnan , Dervišević Lejla , Ajanović Zurifa , Hasanbegović Ilvana , Hadžihalilović Aida Sarač 
Published: November 2023

Background:
In clinical practice, there is a very common discrepancy between the clinical findings of patients with lumboischialgia and the radiological findings.

Objective:
This research aimed to determine the degree of correlation between the ODI index and the VAS scale with degenerative changes in the lumbar spine found using MRI.

Methods:
The study included 100 patients, who were referred for an MRI of the lumbar spine and who had a clear clinical picture of lumboischialgia. Patients underwent MRI. Degenerative changes in the lumbar spine and discs were analysed. Patients were asked to answer the questions in the questionnaire about the subjective feeling of pain and functional status, and ODI and VAS scores were calculated.

Results:
There has been a statistically significant correlation found between the answers to the survey questions and the VAS score (p < 0.001). There was a significant correlation obtained between the level of degeneration and the disability index (p = 0.022), while the correlation with the VAS score has not been found to be significant (p = 0.325).

Conclusion:
This study has demonstrated a significant correlation between the VAS pain score and the ODI, as well as a significant correlation between the level of degeneration on MRI scans and the disability index; however, the correlation of MRI scan results with VAS score has not been found to be significant.
Pediatrician’s Perception of Air Pollution and its Impact on Children’s Health in Indonesia
Authors: Soemarko Dewi Sumaryani , Khoe Levina Chandra , Wasito Erika , Basrowi Ray Wagiu 
Published: November 2023

Introduction:
Air pollution is an unseen threat to children's health as it increases the risk of respiratory infection by impairing immune responses to the respiratory tract. Nevertheless, health promotion emphasizing the impact of air pollution is not popular, even among health professionals. Therefore, this study aimed to explore the perceptions of paediatricians regarding its impact on children’s health in Indonesia.

Materials and Methods:
A cross-sectional design using an online questionnaire was employed in this study. It was composed of 30 items and divided into 4 sections, i.e. section 1 explored the demographic variables, section 2 measured the respondent’s information-seeking behavior on the issue of air pollution, section 3 measured the perception of issues related to air pollution and its impact on children’s health, and section 4 explored the respondent’s experience in practicing environmental health education with respect to their patients. Only completed surveys were analysed.

Results:
Of the 171 pediatricians who were accessed for the survey, 120 (70.2%) completed it. The majority of respondents (69%) resided in Java island and worked in urban areas (84%). About 41.7% of the respondents had little to no information on the impact of air pollution on children’s health. More than 80% of the respondents received information from scientific articles, followed by seminars (61.5%), the internet (53.8%), colleagues (30.7%), and workshops/training (17.3%). Nearly one-third of the respondents considered air quality as poor in their working environment. Almost all agreed that air pollution can affect children’s health and increase the risk of respiratory allergies and even the risk of skin allergies for children under two years of age. In daily practice, most respondents (53.3%) admitted that they never or rarely treated patients with diseases related to air pollution. About one-third of the respondents (36.7%) had never or rarely asked their patients about their living environment.

Conclusion:
Pediatricians are aware of the impact of air pollution on the risk of respiratory allergies and infection, and therefore often provide environmental health education to patients. This study has reported that the majority of pediatricians in Indonesia have an understanding of the impact of air pollution on children’s health; however, there is still a lack of health promotion to be communicated to the patients and their families in their daily practice.
Crop Science Futurology: A Data-Driven Approach Through Phenomic, Genomic and Enviromic Insights
Authors: Adak Alper , Murray Seth C. 
Published: November 2023

In recent years, the use of field-based high-throughput phenotyping
(FHTP) has surged across diverse disciplines. Particularly, it has
gained significant traction in agricultural research, enabling
scientists to efficiently gather extensive data for a deeper
understanding of plant biology in the context of plant growth dynamics.
This abstract aims to demonstrate potential applications of data
obtained through high-throughput phenotyping in the fields of plant
biology and predictive plant breeding.
The study utilized temporal phenotype data derived from repetitive drone
flights equipped with various sensors. These data were incorporated into
a novel mixed model, providing insights into the temporal genetic
effects on different genotypes/plants. Gaussian or Lorentzian peak
models, as well as Functional Principal Component analysis, were
employed to characterize the growth patterns of various genotypes in
diverse environments. The research revealed that Temporal Effect Sizes
of Quantitative Trait Loci (QTLs) influence growth differently across
time points, highlighting the dynamic nature of plant development.
Furthermore, the study uncovered time-dependent associations between
genotypes and their environments based on temporal phenotype values.
The predictive capability of temporal phenomic data was found to surpass
that of genomic data in predicting complex traits in maize. However, the
combination of phenomic and genomic data consistently yielded the most
accurate predictions for complex traits. By analyzing drone flights at
specific growth stages, the study quantified physiological traits such
as senescence progression across multiple time points. This analysis led
to the calculation of new traits, including days to senescence and grain
filing period, providing valuable insights into plant development and
growth dynamics.
The Dynamics of Participation: The Tourism Object Management of Cigaru Blue Lake
Authors: Siregar Herlina , Irfani Lindawati Yustika 
Published: November 2023

Changes are also resulted from the community ‘s efforts to develop Cigaru Blue Lake into a tourist attraction. In connection with all the changes that occur by the community participation, this study aims to describe 1) the stage of community participation in the management of Cigaru Blue Lake tourism object, 2) the dynamics of community participation in the management of the tourism object, and 3) the supporting and inhibiting factors of the community participation in the management of Cigaru Blue Lake tourism object. This study uses a qualitative approach with descriptive method. The data are collected through observations, interview, and documentations. The results of the study show that the dynamics of participation that occurred in Cigaru Blue Lake tourist attraction brought some changes with the addition rides, adequate public facilities, and the ability to collaborate with the local government (Cisoka District). The supporting factors are the programs that are in accordance with the needs and interests of the community and comply with the prevailing values so as to create strong bonds between the communities. Meanwhile, the inhibiting factor is the geographical condition of the region and the week economy state of the community which makes the management run slowly.