bluuebunny/crossref_metadata_2025_split huggingface dataset:
Introduction
Authors: Bruno G Anthony 
Published: January 2025

Abstract
This book provides the first history of the concept of facticity and demonstrates that its coining, transmission, and repurposing by major thinkers after Kant leaves a deep and lasting divide concerning the post-Kantian question of whether a science of intelligibility can tolerate brute facts. This divide is expressed as a fundamental methodological opposition between Fichte and Hegel’s German idealist demand that apparent bruteness be expunged by deductive means, on pain of disowning reason’s freedom and inviting its annihilation, and Heidegger’s phenomenological demand that genuine bruteness be interpreted by hermeneutical means, on pain of evading our finitude and ignoring our thrownness. The primary historical claim will be that we cannot fully understand the path from Kant to German idealism to phenomenology without understanding the momentous trajectory of the concept of facticity. The primary philosophical claim will be that we find in phenomenology’s revival of the Kantian senses of modesty and contingency a defensible and, indeed, superior response to the post-Kantian question.
Resisting Terror
Authors: Argomaniz Javier 
Published: January 2025

Abstract
This book on civil action and nonviolent resistance to terrorism in Basque Country explains the impact of collective action on the decline and end of the separatist armed group ETA. It reflects on how activism by the peace movement helped to delegitimize in society the use of terrorism to achieve political goals by diffusing democratic and nonviolence norms. It explores how civil society actors created new discourses that challenged ETA’s political project. It describes how civil resistance to the armed group undermined the prestige of militants within the community and helped to limit the social reach of violent extremist narratives. It depicts the efforts by social movement organizations to protect the fabric of society from the effects of political violence. It details how peacebuilding efforts by civil society groups were instrumental in building pressure from ETA’s own political movement to leave the armed struggle behind and later facilitate ETA’s disarmament and disbandment. And it indicates how the findings from this study can be extrapolated to go beyond this case and inform terrorism studies, civil resistance, peace and conflict, and social movements scholarship more widely.
Lessons from the Basque Case
Authors: Argomaniz Javier 
Published: January 2025

Abstract
Chapter 6 reviews the arguments presented in the previous empirical chapters and discusses their implications for the fields of terrorism studies and peace and conflict. It details the different mechanisms through which civil action impacted the trajectory of the violence. The chapter situates the main claims within the civil resistance, social movements, and contentious politics literatures, exploring the ramifications of the findings and paying special attention to the way the political opportunity structure and the agency of collective action are interconnected in this case. Finally, it elaborates on the relationship between civil action and the other major factors that are usually recognized in the literature as pivotal for ETA’s defeat.
Conceptualizing Japanese Brazilian and Jewish Brazilian Identities
Authors: Ju Angela 
Published: January 2025

Abstract
This chapter introduces the Pigmentocracy and Perceived Integration Model with a vertical “color” axis and a horizontal perceived integration axis that will be applied to the subsequent empirical chapters. This chapter begins by introducing existing scholarship about the possible identities that Japanese Brazilians and Jewish Brazilians may emphasize in specific contexts, especially though the lenses of theories of political incorporation from Political Science and social integration from Sociology. These works provide the theoretical building blocks of the model. Although scholars typically distinguish between political incorporation and social integration, these processes are deeply intertwined within the context of this study because it is difficult to make progress toward political incorporation without already having made some progress in social integration. For this reason, the chapter discusses these theoretical literatures in relation to one another.
Health-related quality of life and mental health outcomes among cancer survivors in an insomnia intervention: a randomized controlled trial
Authors: Kwon Misol , Zhu Jingtao , Wilding Gregory E , Larkin Karen , Gehrman Philip R , Dickerson Suzanne S 
Published: January 2025

Abstract

Background
While brief behavioral therapy for insomnia (BBTI) has shown promising results in improving sleep outcomes, its effects on health-related quality of life (HRQOL) and mental health among cancer survivors have been understudied.

Purpose
To evaluate the effect of BBTI on HRQOL and mental health outcomes among cancer survivors, relative to an attention control group receiving a healthy eating program (HEP), over periods from baseline to 12 months and from 3 to 12 months.

Methods
A sample of 132 cancer survivors with insomnia symptoms (Mage: 63.7 ± 10 years; 55.3% female) was assessed at baseline, with the final analytical sample of 121 (BBTI = 62, HEP = 59). Self-reported HRQOL, mood disturbance, depression, and anxiety at baseline, 3 months, and 12 months were examined. A multivariate linear model using least squares means evaluated within- and between-group differences.

Results
No significant differences in outcome variables were found between the randomized groups at any time point. Both groups showed significant improvements in total HRQOL, mood disturbance, and anxiety symptoms from baseline to 12 months. Only the BBTI group demonstrated a significant reduction in depressive symptoms within the group, an effect not observed in the HEP group. The most noticeable changes occurred within the first 3 months, with no statistically significant differences from 3 to 12 months within or between groups.

Conclusion
While both randomized groups showed improvements in total HRQOL, mood, and anxiety symptoms, only BBTI produced significant within-group improvements in depressive symptoms over 12 months.

Clinical trial registration
https://ClinicalTrials.gov, NCT03810365.
Synthesis and characterization of thermally stable and water-soluble pantetheine trisulfide and its composites
Authors: Tomonaga Shoichiro , Ishimaru Hiroaki , Misada Shizuki , Isobe Takahiro , Ohshima Etsuo , Kitagaki Shinji 
Published: January 2025

Abstract
We clarified for the first time the synthesis procedure and characterization of pantetheine trisulfide, a potential new drug. Pantetheine trisulfide is the first supersulfur compound with both thermal stability and water solubility. Its hygroscopicity and deliquescence promote the hydrolysis of trisulfide, but these limitations are overcome by powdered composites of pantetheine trisulfide with silica gel or lactose.
Possible multiple origins of some important characteristics of the keel (papilionate) flowers within Fabales
Authors: Aygören Uluer Deniz 
Published: January 2025

Abstract
Keel flowers are bilaterally symmetrical, pentamerous flowers with the reproductive organs enclosed by keel petals. Within Fabales, keel flowers are dominant in two species-rich lineages, tribe Polygaleae (Polygalaceae) and subfamily Fabaceae (Papilionoideae); however, independent events are also observed, such as in the genus Cercis. Prior to advances in phylogenetics (i.e. in contrast to more recent studies), most of the studies hypothesized a non-keeled origin for the Faboideae, although a detailed investigation has never been carried out. In this study, using the results of Aygören Uluer et al. (2020a, 2022a), the origin of some important morphological characters of the keel flower are examined, namely floral symmetry, perianth heteromorphism (i.e. three distinct petal/+sepal types), and the presence of enclosed reproductive organs. These characters are analysed within the Fabales using three different ancestral state analyses based on a phylogeny constructed for 678 taxa using published matK, rbcL, and trnL plastid gene regions. The analyses show that symmetry probably originated in the (Fabaceae + Polygalaceae) clade, while the enclosed reproductive organs and three types of petals appear to have evolved independently multiple times. Interestingly, neither enclosed reproductive organs nor petal heteromorphism evolved in the MRCA of the Faboideae, but rather in a very early stage of the evolution of the subfamily. While future homology assessments and/or evolutionary developmental genetic (evo-devo) studies will be required to more clearly elucidate the evolutionary processes, the current study is the first attempt to investigate the origin of some important characteristics of keel flowers within the order Fabales.
Predicting human olfactory perception by odorant structure and receptor activation profile
Authors: Ihara Yusuke , Ijichi Chiori , Nogi Yasuko , Sugiki Masayuki , Kodama Yuko , Ihara Sayoko , Shirasu Mika , Hirokawa Takatsugu , Touhara Kazushige 
Published: January 2025

Abstract
Humans possess a remarkable ability to discriminate a wide range of odors with high precision. This process begins with olfactory receptors (ORs) detecting and responding to the molecular structures of odorants. Recent studies have aimed to associate the activity of a single OR to an odor descriptor or predict odor descriptors using 2D molecular representation. However, predicting a limited number of odor descriptors is insufficient to fully understand the widespread and elaborate olfactory perception process. Therefore, we conducted structure-activity relationship analyses for ORs of eugenol, vanillin, and structurally similar compounds, investigating the correlation between molecular structures, OR activity profiles, and perceptual odor similarity. Our results indicated that these structurally similar compounds primarily activated six ORs, and the activity profiles of these ORs correlated with their perception. This enabled the development of a prediction model for the eugenol-similarity score from OR activity profiles (coefficient of determination, R2 = 0.687). Furthermore, the molecular structures of odorants were represented as 3D shapes and pharmacophore fingerprints, considering the 3D structural similarities between various odorants with multiple conformations. These 3D shape and pharmacophore fingerprints could also predict the perceptual odor similarity (R2 = 0.514). Finally, we identified key molecular structural features that contributed to predicting sensory similarities between compounds structurally similar to eugenol and vanillin. Our models, which predict odor from OR activity profiles and similarities in the 3D structure of odorants, may aid in understanding olfactory perception by compressing the information from a vast number of odorants into the activity profiles of 400 ORs.
Range delimitation and flight phenology for Archips goyerana (Lepidoptera: Tortricidae), a significant defoliator of baldcypress
Authors: McAndrew Kristy M , Coyle David R , Gomez Demian F , Oten Kelly L F , Sheehan Thomas N , Sullivan Brian T , Ward Samuel F 
Published: January 2025

Abstract
Forested wetlands support diverse biota and provide a wide range of ecosystem services. Archips goyerana Kruse (Lepidoptera: Tortricidae) is a native pest that defoliates baldcypress (Taxodium distichum var. distichum (L.) Rich.; Cupressaceae) and pondcypress (Taxodium distichum var. imbricarium (Nuttall); Croom), 2 keystone trees throughout forested wetlands of the southeastern United States. Outbreaks of the A. goyerana have been isolated to southeastern Louisiana, where they have caused reduced growth, crown dieback, and limited tree death. However, aerial detection surveys indicated that severe defoliation by A. goyerana has been affecting wetlands further east within the region. Given the possibility of expanding outbreaks, it is important to understand the timing of A. goyerana activity, duration of the flight period, and efficacy of different trap types to guide survey efforts. We deployed traps in a paired design, one bucket trap and one delta trap, each baited with synthetic A. goyerana sex pheromone at 30 sites throughout the range of baldcypress. Over 2 field seasons, we checked traps weekly and quantified the number of A. goyerana caught per trap type, ability of each trap type to detect a single moth (trap sensitivity), and growing degree days, using a base temperature of 5 °C accumulated at the onset, peak, and cessation of the flight period. We found that delta traps caught more moths but sensitivity of traps was equal between the 2 trap types. Analyses of phenology indicated that A. goyerana flight occurred between ~1,000 and 1,600 growing degree days. Optimizing trapping practices for A. goyerana may improve detection of endemic populations and help identify areas potentially at risk of experiencing outbreaks.
The Sea Lamprey (Petromyzon marinus) Invasion: The Construction of an Invasive Animal Threatening a “Healthy” Great Lakes Ecosystem
Authors: Bijman Vincent 
Published: January 2025

Abstract
During the late 1930s, Great Lakes fishermen became concerned because of the new occurrence of the sea lamprey (Petromyzon marinus). Originally an Atlantic coastal fish, it was allowed to migrate throughout the Great Lakes due to various canal extensions. By drawing from literature on the sociology of environmental problems and animal invasions, this article traces how the sea lamprey became problematized as a threatening invader between the late 1930s and early 1970s. Throughout this period, a broad coalition of fishery biologists, fishermen, politicians, and journalists were involved in framing the problem. Although sea lamprey research, localized control practices, and environmental discourses considerably changed, the sea lamprey continued to be regarded as an invasive fish that was not allowed to exist in the Great Lakes. The case shows how these shifting ways of understanding the problem in fact led to the continuation of past management directions.
Human papillomavirus-related squamous cell carcinomas after blood or marrow transplantation—a BMTSS report
Authors: Holmqvist Anna Sällfors , Meng Qingrui , Landier Wendy , Hageman Lindsey , Francisco Liton F , Ross Elizabeth Schlichting , Balas Nora , Bosworth Alysia , Te Hok Sreng , Bhatia Ravi , Wong F Lennie , Weisdorf Daniel , Armenian Saro H , Bhatia Smita 
Published: January 2025

Abstract

Background
Human papillomavirus (HPV) is associated with an increased risk for a variety of squamous cell carcinomas (SCCs) in the general population. The risk for subsequent SCCs in BMT survivors that are potentially related to HPV (cervical, oropharyngeal, vulvar, vaginal, anal, and penile cancer; HPV-related SCCs) remains unknown.

Methods
We determined the risk of HPV-related SCCs in 7,936 2 y-survivors of autologous or allogeneic BMT performed between 1974 and 2014 and identified the role of demographic and clinical factors associated with HPV-related SCCs using proportional subdistribution hazards model for competing risks. Standardized incidence ratio (SIR) was used to compare the risk of HPV-related SCC with age-, sex-, and calendar-specific incidence in the general population.

Results
The median age at transplantation was 46 y (range, 0-78 y); 58.5% (n = 4,642) were males, and 72.2% (n = 5,727) were non-Hispanic White. Half of the patients (50.3%, n = 3,991) had received an allogeneic BMT. The SIR for oropharyngeal SCC (n = 53) was 1.8 (95%CI = 1.3-2.3) and for cervical SCC among female BMT recipients (n = 26) was 9.4 (95%CI = 6.3-13.6), compared to the general US population. The hazard of an HPV-related SCC was higher among allogeneic BMT recipients with chronic graft vs host disease (cGvHD) (any HPV-related SCC: HR = 6.24, 95%CI = 3.11-12.50; oropharyngeal: HR = 4.85, 95%CI = 2.11-11.15; cervical: HR = 4.98, 95%CI = 1.65-15.00; reference=autologous BMT). Pre-BMT radiation increased the risk of oropharyngeal SCC (HR = 2.98, 95%CI = 1.57-5.65).

Conclusion
These findings underscore the importance of risk-based HPV vaccination and surveillance after BMT.
NF2 loss-of-function and hypoxia drive radiation resistance in grade 2 meningiomas
Authors: Patel Bhuvic , Pugazenthi Sangami , English Collin W , Nitturi Vijay , Pari Shree S , Mahlokozera Tatenda , Leidig William A , Lu Hsiang-Chih , Yang Alicia , Roberts Kaleigh , DeSouza Patrick , McGeehan Kyle P , Mao Diane D , Sinha Namita , Ippolito Joseph E , Dahiya Sonika , Petti Allegra , Yano Hiroko , Klisch Tiemo J , Harmanci Akdes S , Patel Akash J , Kim Albert H 
Published: January 2025

Abstract

Background
World Health Organization Grade 2 meningiomas (G2Ms) often recur and resist therapies. G2Ms with histopathological necrosis have been associated with worse local control (LC) following radiation therapy, but the drivers and biomarkers of radiation resistance in G2Ms remain unknown.

Methods
We performed genetic sequencing and histopathological analysis of 113 G2Ms and investigated the role of genetic and microenvironmental factors on clonogenic survival following ionizing radiation. We performed transcriptional profiling of our in vitro model and 18 human G2M tumors by bulk RNA sequencing as well as eight G2Ms by single nuclei RNA sequencing.

Results
NF2 loss-of-function (LOF) mutations were associated with necrosis in G2Ms (p = .0127). Tumors with NF2 mutation and necrosis had worse post-radiation LC compared to NF2 wildtype tumors without necrosis (p = .035). Under hypoxic conditions, NF2 knockdown increased radiation resistance in vitro (p &lt; .001). Bulk RNA sequencing revealed NF2- and hypoxia-specific changes and a 50-gene set signature specific to radiation resistant, NF2 knockdown and hypoxic cells, which distinguished NF2 mutant/necrotic patient G2Ms by unsupervised clustering. Enrichment analysis revealed downregulation of apoptosis pathway genes and upregulation of proliferation-associated genes and genes normally downregulated after UV radiation exposure in NF2-mutant/necrotic tumor cells, which were validated with functional assays.

Conclusions
NF2 LOF in the setting of hypoxia confers radiation resistance through transcriptional programs that reduce apoptosis and promote proliferation. These pathways may identify tumors resistant to radiation and represent therapeutic targets that in the future could improve LC in patients with radiation resistant G2Ms.
Size matters: early progression of melanoma brain metastases after treatment with immune checkpoint inhibitors
Authors: Derks S H A E , Ho L S , Koene S R , Starmans M P A , Oomen-de Hoop E , Joosse A , de Jonge M J A , Naipal K A T , Jongen J L M , van den Bent M J , Smits M , van der Veldt A A M 
Published: January 2025

Abstract

Background
Immune checkpoint inhibitors (ICIs) are effective treatments for patients with metastatic melanoma, including patients with brain metastasis (BM). However, half of patients with melanoma BM have intracranial progression within six months after the start of ICIs. We investigated whether size affects response to ICIs in patients with melanoma BM.

Methods
In this single-centre cohort study, patients with melanoma BM who were treated with ICIs between 2012 and 2021 were included. Clinical and radiologic features were collected at baseline. Longest axial diameter of all BMs was measured on baseline and follow-up MRI, and segmentation was performed for all BMs on baseline MRI. Lesion-level logistic regression analysis and patient-level survival analysis were performed for early BM progression (i.e. within six months after start of ICIs) and intracranial progression-free survival (PFS), respectively.

Results
A total of 82 patients were included with a total of 464 BMs. At baseline, 37.8% of patients had ≥4 BMs and 53.7% of patients had at least one BM with a diameter ≥10mm. In multivariable analysis on the lesion level, baseline BM diameter was associated with early BM progression (Odds ratio 1.10, 95%CI 1.05-1.15, p&lt;0.001). On the patient level, having at least one BM ≥10mm was associated with shorter intracranial PFS (Hazard ratio 2.08, 95%CI 1.64-5.56, p&lt;0.001).

Conclusions
Large BM diameter was associated with a higher risk of early progression after the start of ICIs. Therefore, local therapy should be considered for patients who are treated with ICIs and who have melanoma BMs ≥10mm.
HIV-related differences in placental immunology: Data from the PRACHITi cohort in Pune, India
Authors: Mathad Jyoti S , Alexander Mallika , Bhosale Ramesh , Naik Shilpa , Cranmer Lisa Marie , Kulkarni Vandana , Busch Sydney , Chalem Andrea , Gitlin Emily , Lei Jun , Liu Anguo , Liu Jin , Liu Yang , Shivakoti Rupak , Gupta Amita , Burd Irina 
Published: January 2025

Abstract

Background
Maternal HIV infection can affect placental immunology and expression of the neonatal crystallizable fragment receptor (FcRn), which allows transplacental antibody transfer. This study delineated differences in placental FcRn and T-cell expression by HIV status, with or without viral suppression.

Methods
This observational cohort study in Pune, India, followed pregnant women with and without HIV through one year postpartum; 42 had placenta collected, stratified by HIV status. FcRn expression was analyzed by Western blot (normalized by GADPH) and compared using ImageJ. Placental CD4/CD8 abundance was assessed by immunofluorescent counting per high powered field.

Results
The median gestational age at delivery was 38.3 weeks (IQR: 37.5-39.1). Of 18 women living with HIV, all were on combined antiretroviral therapy with a median CD4 of 455 cells/mm3 (IQR 281-640) at entry and 429 cells/mm3 (IQR 317-686) at delivery. Ten had undetectable virus (£40 copies/mL); of those with detectable virus, the median viral load was 151 copies/mL (IQR: 118.15-539334). Relative placental FcRn expression was lower in women living with HIV compared to without (median 0.54 vs. 0.84, p=0.01) and not associated with CD4 or viral load. Women living with HIV had significantly higher abundance of placental CD8+ T-cells, regardless of viral suppression, compared to women without.

Conclusions
Maternal HIV, even with viral suppression, is associated with lower placental FcRn expression and increased placental CD8+ T-cells. These results suggest that dysregulation may not be completely reversed by antiretroviral therapy and could contribute to poorer infant outcomes, even in the absence of mother-to-child HIV transmission.