bluuebunny/crossref_metadata_2025_split huggingface dataset:
Off-label use of large diameter Concerto fibered coils through a 0.017 inch microcatheter for transvenous embolization of indirect carotid-cavernous fistulas: two case reports
Authors: Hsieh Justin T. , Chia Ghim Song , Wong Chen Pong , Lim Winston Eng Hoe , Wen David W. 
Published: February 2024

Abstract
Background
A carotid-cavernous fistula is an abnormal communication between the arteries and veins within the cavernous sinus. While conservative management may be prudent in low risk cases, many patients require intervention and endovascular embolization has evolved as the preferred method of treatment. Embolization can be performed via either the transarterial or transvenous approach. One major challenge of the transvenous approach is the complex and variable compartmentation of the cavernous sinus, which often requires the use of low profile microcatheters to navigate and reach the fistulous point. Fibered coils are also preferred when performing transvenous embolization of carotid-cavernous fistula, as they are of higher thrombogenicity and allow for faster occlusion of the fistula. However, most low profile (0.017-inch) microcatheters are not able to deploy fibered coils based on the manufacturer’s instructions.

Case presentation
We present two successful cases of off-label use of Medtronic Concerto fibered coils via a 0.017-inch microcatheter during transvenous embolization of carotid-cavernous fistula in a 60-year-old and an 80-year-old Chinese female, respectively.

Conclusion
Our case series highlight the possibility of deploying large diameter (up to 10 mm) Concerto fibered coils through a low profile (0.017-inch) microcatheter in an off-label manner for transvenous embolization of indirect carotid-cavernous fistula.
The role of Helicobacter suis, Fusobacterium gastrosuis, and the pars oesophageal microbiota in gastric ulceration in slaughter pigs receiving meal or pelleted feed
Authors: Taillieu Emily , Taelman Steff , De Bruyckere Sofie , Goossens Evy , Chantziaras Ilias , Van Steenkiste Christophe , Yde Peter , Hanssens Steven , De Meyer Dimitri , Van Criekinge Wim , Stock Michiel , Maes Dominiek , Chiers Koen , Haesebrouck Freddy 
Published: February 2024

AbstractThis study investigated the role of causative infectious agents in ulceration of the non-glandular part of the porcine stomach (pars oesophagea). In total, 150 stomachs from slaughter pigs were included, 75 from pigs that received a meal feed, 75 from pigs that received an equivalent pelleted feed with a smaller particle size. The pars oesophagea was macroscopically examined after slaughter. (q)PCR assays for H. suis, F. gastrosuis and H. pylori-like organisms were performed, as well as 16S rRNA sequencing for pars oesophagea microbiome analyses. All 150 pig stomachs showed lesions. F. gastrosuis was detected in 115 cases (77%) and H. suis in 117 cases (78%), with 92 cases (61%) of co-infection; H. pylori-like organisms were detected in one case. Higher infectious loads of H. suis increased the odds of severe gastric lesions (OR = 1.14, p = 0.038), while the presence of H. suis infection in the pyloric gland zone increased the probability of pars oesophageal erosions [16.4% (95% CI 0.6–32.2%)]. The causal effect of H. suis was mediated by decreased pars oesophageal microbiome diversity [−1.9% (95% CI − 5.0–1.2%)], increased abundances of Veillonella and Campylobacter spp., and decreased abundances of Lactobacillus, Escherichia-Shigella, and Enterobacteriaceae spp. Higher infectious loads of F. gastrosuis in the pars oesophagea decreased the odds of severe gastric lesions (OR = 0.8, p = 0.0014). Feed pelleting had no significant impact on the prevalence of severe gastric lesions (OR = 1.72, p = 0.28). H. suis infections are a risk factor for ulceration of the porcine pars oesophagea, probably mediated through alterations in pars oesophageal microbiome diversity and composition.
Comparison of fish oil supplements and corn oil effects on serum lipid profile: a systematic review and meta-analysis of randomized controlled trials
Authors: Safaei Payam , Bayat Ghazal , Mohajer Afsaneh 
Published: February 2024

Abstract
Background
The present study aimed to investigate the effects of fish oil supplements compared to corn oil on serum lipid profiles by performing a meta-analysis of randomized controlled trials (RCTs).

Methods
Online databases including PubMed, Web of Science, and Scopus were searched until 30 December 2022. Pooled effect sizes were reported as the weighted mean difference (WMD) with 95% confidence intervals (CI). The Cochrane Collaboration’s risk-of-bias tool was utilized to evaluate the quality of the studies. Lipid parameters, including triglycerides (TG), total cholesterol (TC), low-density lipoprotein cholesterol (LDL), and high-density lipoprotein cholesterol (HDL), were assessed in the meta-analysis.

Results
Overall, 16 eligible trials were included in this systematic review and meta-analysis. The results revealed that the fish oil supplements significantly reduced TG (WMD: − 25.50 mg/dl, 95% CI: − 42.44, − 8.57, P = 0.000) levels compared to corn oil. Also, in this study, fish oil supplements had a positive and significant effect on HDL (WMD: 2.54 mg/dl, 95% CI: 0.55, 4.52). There were no significant changes in TC and LDL.

Conclusions
Our findings showed the effects of fish oil supplements on reducing TG and increasing HDL-c compared to corn oil. Further larger and well-designed RCTs are required to confirm these data.
Multiple positive solutions for Schrödinger-Poisson system with singularity on the Heisenberg group
Authors: Tian Guaiqi , An Yucheng , Suo Hongmin 
Published: February 2024

AbstractIn this work, we study the following Schrödinger-Poisson system $$ \textstyle\begin{cases} -\Delta _{H}u+\mu \phi u=\lambda u^{-\gamma}, &\text{in } \Omega , \\ -\Delta _{H}\phi =u^{2}, &\text{in } \Omega , \\ u>0, &\text{in } \Omega , \\ u=\phi =0, &\text{on } \partial \Omega , \end{cases} $$

{

−

Δ
H

u
+
μ
ϕ
u
=
λ

u

−
γ

,

in
Ω
,

−

Δ
H

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=

u
2

,

in
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,

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0
,

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,

u
=
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=
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on
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where $\Delta _{H}$

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is the Kohn-Laplacian on the first Heisenberg group $\mathbb{H}^{1}$

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1

, and $\Omega \subset \mathbb{H}^{1}$
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is a smooth bounded domain, $\mu =\pm 1$
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=
±
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, $0<\gamma <1$
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<
γ
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, and $\lambda >0$
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are some real parameters. For the above system, we prove the existence and uniqueness of positive solution for $\mu =1$
μ
=
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and each $\lambda >0$
λ
>
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. Multiple solutions of the system are also considered for $\mu =-1$
μ
=
−
1
and $\lambda >0$
λ
>
0
small enough using the critical point theory for nonsmooth functional.
Stability analysis of fractional order breast cancer model in chemotherapy patients with cardiotoxicity by applying LADM
Authors: Mohammadpoor Hajar , Eghbali Nasrin , Sajedi Leila , Nosrati Sahlan Monireh 
Published: February 2024

AbstractBreast cancer is the most common type of cancer in women. Chemotherapy is primarily used for patients with stage 2 to 4 breast cancer. Most chemotherapy drugs are effective at destroying rapidly growing and proliferating cancer cells. However, drugs also damage normal, rapidly growing cells, which can lead to serious side effects. Breast cancer treatment with chemotherapy can affect heart health. Side effects of chemotherapy on the heart are called cardiotoxicity. Therefore, we have constructed a mathematical model from the breast cancer patient population. In this article, we utilize the Caputo–Fabrizio fractional order derivative for mathematical modeling of the breast cancer stages in chemotherapy patients. The use of Caputo–Fabrizio fractional derivative provides a more valuable insight into the complexity of the breast cancer model. The stability of the fractional order model is also proven by the $\mathscr{P}$
P
-stable approach of the fixed point theorem. Also, the numerical simulations are performed via Laplace Adomian decomposition method to establish the dependence of the breast cancer dynamics on the order of the fractional derivatives. Based on the geometric results in the figures, we can conclude that the magnitude of the fractional order has a considerable impact on the days, which the maximum or minimum of the system solutions are reached, with a shift in the time at which this happens as the fractional order decreases from 1. However, it is obvious that the solutions of Caputo–Fabrizio fractional model approach the relevant results of the classical integer order system, when the fractional order approaches to 1.
Simultaneous determination of sulfonylurea herbicides in tomatoes using the QuEChERS method coupled with HPLC
Authors: Han Sang Gyu , Nam Tae Gyu 
Published: February 2024

AbstractThe simultaneous determination of trace pesticides in complex matrices containing high concentrations of natural pigments remains challenging. In this study, quick, easy, cheap, effective, rugged, and safe (QuEChERS) sample preparation together with high-performance liquid chromatography with ultraviolet detection (HPLC–UV) was applied for the multi-residue analysis of seven sulfonylurea herbicides (SUHs) in tomatoes. SUH residue was extracted using the QuEChERS procedure, followed by solid-phase extraction (SPE) and dispersive SPE (d-SPE). To reduce the amount of carotenoids in tomato extracts, several d-SPE clean-up procedures were compared, and octadecylsilane (C18) provided the best color removal rate (%) of tomato extracts and recoveries (%) for all the tested SUHs. The validation results indicate good linearity (R2 > 0.9970), accuracy, and precision. Recoveries of 70–120% and relative standard deviations < 20% were achieved for all analytes at three spiked concentrations. The limits of detection and quantification for the 7 SUHs were 0.003 mg kg−1 and 0.008–0.009 mg kg−1, respectively. The developed method was subsequently used to quantify multi-residue SUHs during real sample analysis. None of the tested samples had SUH residue levels higher than the maximum residue limits established by the Korean Ministry of Food and Drug Safety. The results suggest that QuEChERS sample preparation employing a combination of C18 is a high-throughput and rapid clean-up procedure for the multi-residue analysis of SUHs in tomatoes.
Gut microbiota-derived LCA mediates the protective effect of PEDV infection in piglets
Authors: Xing Jun-Hong , Niu Tian-Ming , Zou Bo-Shi , Yang Gui-Lian , Shi Chun-Wei , Yan Qing-Song , Sun Ming-Jie , Yu Tong , Zhang Shu-Min , Feng Xi-Ze , Fan Shu-Hui , Huang Hai-Bin , Wang Jun-Hong , Li Ming-Han , Jiang Yan-Long , Wang Jian-Zhong , Cao Xin , Wang Nan , Zeng Yan , Hu Jing-Tao , Zhang Di , Sun Wu-Sheng , Yang Wen-Tao , Wang Chun-Feng 
Published: February 2024

Abstract
Background
The gut microbiota is a critical factor in the regulation of host health, but the relationship between the differential resistance of hosts to pathogens and the interaction of gut microbes is not yet clear. Herein, we investigated the potential correlation between the gut microbiota of piglets and their disease resistance using single-cell transcriptomics, 16S amplicon sequencing, metagenomics, and untargeted metabolomics.

Results
Porcine epidemic diarrhea virus (PEDV) infection leads to significant changes in the gut microbiota of piglets. Notably, Landrace pigs lose their resistance quickly after being infected with PEDV, but transplanting the fecal microbiota of Min pigs to Landrace pigs alleviated the infection status. Macrogenomic and animal protection models identified Lactobacillus reuteri and Lactobacillus amylovorus in the gut microbiota as playing an anti-infective role. Moreover, metabolomic screening of the secondary bile acids’ deoxycholic acid (DCA) and lithocholic acid (LCA) correlated significantly with Lactobacillus reuteri and Lactobacillus amylovorus, but only LCA exerted a protective function in the animal model. In addition, LCA supplementation altered the distribution of intestinal T-cell populations and resulted in significantly enriched CD8+ CTLs, and in vivo and in vitro experiments showed that LCA increased SLA-I expression in porcine intestinal epithelial cells via FXR receptors, thereby recruiting CD8+ CTLs to exert antiviral effects.

Conclusions
Overall, our findings indicate that the diversity of gut microbiota influences the development of the disease, and manipulating Lactobacillus reuteri and Lactobacillus amylovorus, as well as LCA, represents a promising strategy to improve PEDV infection in piglets.
LINC01559 promotes lung adenocarcinoma metastasis by disrupting the ubiquitination of vimentin
Authors: Feng Hao , Xu Dengfei , Jiang Chenyang , Chen Yuming , Wang Junru , Ren Zirui , Li Xiang , Zhang Xu Dong , Cang Shundong 
Published: February 2024

Abstract
Background
Distant metastasis is the major cause of lung adenocarcinoma (LUAD)-associated mortality. However, molecular mechanisms involved in LUAD metastasis remain to be fully understood. While the role of long non-coding RNAs (lncRNAs) in cancer development, progression, and treatment resistance is being increasingly appreciated, the list of dysregulated lncRNAs that contribute to LUAD pathogenesis is also rapidly expanding.

Methods
Bioinformatics analysis was conducted to interrogate publicly available LUAD datasets. In situ hybridization and qRT-PCR assays were used to test lncRNA expression in human LUAD tissues and cell lines, respectively. Wound healing as well as transwell migration and invasion assays were employed to examine LUAD cell migration and invasion in vitro. LUAD metastasis was examined using mouse models in vivo. RNA pulldown and RNA immunoprecipitation were carried out to test RNA–protein associations. Cycloheximide-chase assays were performed to monitor protein turnover rates and Western blotting was employed to test protein expression.

Results
The expression of the lncRNA LINC01559 was commonly upregulated in LUADs, in particular, in those with distant metastasis. High LINC01559 expression was associated with poor outcome of LUAD patients and was potentially an independent prognostic factor. Knockdown of LINC01559 diminished the potential of LUAD cell migration and invasion in vitro and reduced the formation of LUAD metastatic lesions in vivo. Mechanistically, LINC01559 binds to vimentin and prevents its ubiquitination and proteasomal degradation, leading to promotion of LUAD cell migration, invasion, and metastasis.

Conclusion
LINC01559 plays an important role in LUAD metastasis through stabilizing vimentin. The expression of LINC01559 is potentially an independent prognostic factor of LUAD patients, and LINC01559 targeting may represent a novel avenue for the treatment of late-stage LUAD.
Altered amyloid-β structure markedly reduces gliosis in the brain of mice harboring the Uppsala APP deletion
Authors: Pagnon de la Vega María , Syvänen Stina , Giedraitis Vilmantas , Hooley Monique , Konstantinidis Evangelos , Meier Silvio R. , Rokka Johanna , Eriksson Jonas , Aguilar Ximena , Spires-Jones Tara L. , Lannfelt Lars , Nilsson Lars N. G. , Erlandsson Anna , Hultqvist Greta , Ingelsson Martin , Sehlin Dag 
Published: February 2024

AbstractDeposition of amyloid beta (Aβ) into plaques is a major hallmark of Alzheimer’s disease (AD). Different amyloid precursor protein (APP) mutations cause early-onset AD by altering the production or aggregation properties of Aβ. We recently identified the Uppsala APP mutation (APPUpp), which causes Aβ pathology by a triple mechanism: increased β-secretase and altered α-secretase APP cleavage, leading to increased formation of a unique Aβ conformer that rapidly aggregates and deposits in the brain. The aim of this study was to further explore the effects of APPUpp in a transgenic mouse model (tg-UppSwe), expressing human APP with the APPUpp mutation together with the APPSwe mutation. Aβ pathology was studied in tg-UppSwe brains at different ages, using ELISA and immunohistochemistry. In vivo PET imaging with three different PET radioligands was conducted in aged tg-UppSwe mice and two other mouse models; tg-ArcSwe and tg-Swe. Finally, glial responses to Aβ pathology were studied in cell culture models and mouse brain tissue, using ELISA and immunohistochemistry. Tg-UppSwe mice displayed increased β-secretase cleavage and suppressed α-secretase cleavage, resulting in AβUpp42 dominated diffuse plaque pathology appearing from the age of 5–6 months. The γ-secretase cleavage was not affected. Contrary to tg-ArcSwe and tg-Swe mice, tg-UppSwe mice were [11C]PiB-PET negative. Antibody-based PET with the 3D6 ligand visualized Aβ pathology in all models, whereas the Aβ protofibril selective mAb158 ligand did not give any signals in tg-UppSwe mice. Moreover, unlike the other two models, tg-UppSwe mice displayed a very faint glial response to the Aβ pathology. The tg-UppSwe mouse model thus recapitulates several pathological features of the Uppsala APP mutation carriers. The presumed unique structural features of AβUpp42 aggregates were found to affect their interaction with anti-Aβ antibodies and profoundly modify the Aβ-mediated glial response, which may be important aspects to consider for further development of AD therapies.
Prediction of [177Lu]Lu-DOTA-TATE therapy response using the absorbed dose estimated from [177Lu]Lu-DOTA-TATE SPECT/CT in patients with metastatic neuroendocrine tumour
Authors: Ha Sejin , Kim Yong-il , Oh Jungsu S. , Yoo Changhoon , Ryoo Baek-Yeol , Ryu Jin-Sook 
Published: February 2024

Abstract
Background
Peptide receptor radionuclide therapy (PRRT) with [177Lu]Lu-DOTA-TATE has shown efficacy in patients with metastatic neuroendocrine tumours (NETs). Personalised dosimetry is crucial to optimise treatment outcomes and minimise adverse events. In this study, we investigated the correlation between the tumour-absorbed dose (TAD) estimated from [177Lu]Lu-DOTA-TATE SPECT/CT and the therapeutic response.

Method
A retrospective analysis was conducted on patients with advanced well-differentiated NETs grades 1–3 who underwent PRRT and exhibited greater uptake than liver on pre-therapeutic [68Ga]Ga-DOTA-TOC PET/CT. Target lesions were selected based on the RECIST 1.1 and PERCIST 1.0 criteria using [177Lu]Lu-DOTA-TATE SPECT/CT and pre-therapeutic contrast-enhanced CT scans. For anatomical image analysis, the sum of the longest diameter (SLD) of the target lesions was measured using the RECIST 1.1 criteria for patient-based analysis and the longest diameter (LD) of the target lesion using the RECIST-L criteria for lesion-based analysis. Standardised uptake values (SUVs) were measured on SPECT/CT images, and TADs were calculated based on the SUVs. Dosimetry was performed using a single SPECT/CT imaging time point at day 4–5 post-therapy. Statistical analyses were conducted to investigate correlations and determine the target lesion responses.

Results
Twenty patients with primary tumour sites and hepatic metastases were included. Fifty-five target lesions, predominantly located in the pancreas and liver, were analysed. The cumulative TAD (lesion-based analysis: r = 0.299–0.301, p = 0.025–0.027), but not the cycle 1 SUV (lesion-based analysis: r = 0.198–0.206, p = 0.131–0.147) or cycle 1 TAD (lesion-based analysis: r = 0.209–0.217, p = 0.112–0.126), exhibited a significant correlation with the change in LD of the target lesion. Binary logistic regression analysis identified the significance of the cumulative TAD in predicting disease control according to the RECIST-L criteria (odds ratio = 1.031–1.051, p = 0.024–0.026).

Conclusions
The cumulative TAD estimated from [177Lu]Lu-DOTA-TATE SPECT/CT revealed a significant correlation with change in LD, which was significantly higher for the cumulative TAD than for the cycle 1 SUV or TAD. A higher cumulative TAD was associated with disease control in the target lesion. However, considering the limitations inherent to a confined sample size, careful interpretation of these findings is required. Estimation of the cumulative TAD of [177Lu]Lu-DOTA-TATE therapy could guide the platform towards personalised therapy.
Rethinking diaspora remittances in the post-Mugabe era in Zimbabwe
Authors: Moyo Inocent 
Published: February 2024

AbstractBased on a qualitative study of Zimbabwean migrants based in South Africa, who regularly remitted goods and money to Zimbabwe between 2010 and 2020, this paper suggests that at a local level, remittances alleviated poverty with very limited if any transformation of the political economy at the national level. Such remittances promoted consumerism without sustainable investment that can structurally transform the economy. In addition, the dependence on remittances entrenches the culture of migration at the local level, which also contributes to or promotes ethno-tribal fissiparity. In rethinking diaspora remittances in the post-Mugabe era, it is advanced that the seemingly intractable economic and political quagmire in Zimbabwe must be resolved to inspire confidence in the diaspora to pull remittances together for a national socio-economic cause and not local-level band-aid accomplishments which remittances currently do.
Navigating meaningful engagement: lessons from partnering with youth and families in brain-based disability research
Authors: Nguyen Linda , Pozniak Kinga , Strohm Sonya , Havens Jessica , Dawe-McCord Claire , Thomson Donna , Putterman Connie , Arafeh Dana , Galuppi Barb , Ley Alicia Via-Dufresne , Doucet Shelley , Amaria Khush , Kovacs Adrienne H. , Marelli Ariane , Rozenblum Ronen , Gorter Jan Willem ,   CHILD-BRIGHT READYorNot™ Brain-Based Disabilities Trial Study Group
Published: February 2024

Abstract
Background
While patient and family engagement in research has become a widespread practice, meaningful and authentic engagement remains a challenge. In the READYorNot™ Brain-Based Disabilities Study, we developed the MyREADY Transition™ Brain-Based Disabilities App to promote education, empowerment, and navigation for the transition from pediatric to adult care among youth with brain-based disabilities, aged 15–17 years old. Our research team created a Patient and Family Advisory Council (PFAC) to engage adolescents, young adults, and parent caregivers as partners throughout our multi-year and multi-stage project.

Main body
This commentary, initiated and co-authored by members of our PFAC, researchers, staff, and a trainee, describes how we corrected the course of our partnership in response to critical feedback from partners. We begin by highlighting an email testimonial from a young adult PFAC member, which constituted a “critical turning point,” that unveiled feelings of unclear expectations, lack of appreciation, and imbalanced relationships among PFAC members. As a team, we reflected on our partnership experiences and reviewed documentation of PFAC activities. This process allowed us to set three intentions to create a collective goal of authentic and meaningful engagement and to chart the course to get us there: (1) offering clarity and flexibility around participation; (2) valuing and acknowledging partners and their contributions; and (3) providing choice and leveraging individual interests and strengths. Our key recommendations include: (1) charting the course with a plan to guide our work; (2) learning the ropes by developing capacity for patient-oriented research; (3) all hands on deck by building a community of engagement; and (4) making course corrections and being prepared to weather the storms by remaining open to reflection, re-evaluation, and adjustment as necessary.

Conclusions
We share key recommendations and lessons learned from our experiences alongside examples from the literature to offer guidance for multi-stage research projects partnering with adolescents, young adults, and family partners. We hope that by sharing challenges and lessons learned, we can help advance patient and family engagement in research.