bluuebunny/crossref_metadata_2025_split huggingface dataset:
Tension Headache: A Comparison of Menstrual and Non‐Menstrual Occurrences
Authors: Solbach Patricia , Sargent Joseph , Coyne Lolafaye , Malone Leslie , Simons Alan 
Published: June 2005

SYNOPSISHeadache is a common complaint with the menstrual period. Although research studies now appear on menstrual migraine headache, little research has examined the differences in tension headaches occurring with the menses and at other times. In this study 32 women were followed over nine months during which headache activity was charted daily for both menstruating and non‐menstruating days. All subjects had been diagnosed with tension headaches. The average sample age was 29 years; subjects reported having a headache problem an average of 13 years prior to study entry.Comparisons of headache activity using headache frequency, duration, and intensity and disability based on example‐anchored scales, were made between menstrual and non‐menstrual days. Menstrual days were defined as the three days prior to the flow and the days of the flow. Treatment outcome comparing the effectiveness of non‐drug techniques for the menstrual and non‐menstrual days was also evaluated.Problems unique to the study were encountered in the analysis and interpretation of the data due to the individual differences in menstrual patterns and cycle starting points in the study. Statistical analysis showed some differences between the menstruating and non‐menstruating headache occurrences. In general, the menstrual headaches were slightly more intense, decreased less across time, and responded less to non‐drug treatments than the non‐menstrual headaches.
Seasonal and Meteorological Factors in Primary Headaches
Authors: Marrelli A. , Marini C. , Prencipe M. 
Published: June 2005

SYNOPSISIn a retrospective survey using a standardized format, 495 patients with “primary headaches” (classic migraine, common migraine, tension headaches, and mixed headaches) were questioned about the role of the seasons and of weather changes in influencing the frequency of their headache attacks. Seasonal influences were more prominent in migraine than in the other headache syndromes, and spring exacerbetions were particularly characteristic of classic migraine. On the other hand, rapid atmospheric variations (quick weather changes) were more potent as headache triggers in mixed headaches than in classic migraine or tension headaches. These differences assist in the delineation of classic migraine as an individual entity.
Naproxen Sodium for Muscle Contraction Headache Treatment
Authors: Sargent Joseph D. , Peters Kenneth , Goldstein Jerome , Madison David S. , Solbach Patricia 
Published: June 2005

SYNOPSISIn this multicenter, double‐blind, parallel study, patients with muscle contraction headache were randomized to treatment with either two naproxen sodium 275 mg capsules per headache or matching placebo. Of a total of 161 patients enrolled, 137 received trial medication and 134 (63 taking naproxen sodium and 71 taking placebo) were valid for efficacy analysis. During four headache episodes, patients recorded, on a visual analog scale, pain intensity just before the dose of trial medication (baseline) and at1, 2, and 4 hours after this dose. For each patient, two additional indices were derived from these data: Pain Intensity Difference (PID), the difference between intensity of pain at baseline and intensity of pain recorded at any time after treatment began; and Summed Pain Intensity Difference (SPID), the sum of the PIDs at a given hour. Results significantly favored naproxen sodium over placebo (p<0.05) at all times. Naproxen sodium was found to be well tolerated and was more efficacious than placebo in the treatment of muscle contraction headache.
The Psychological Treatment of Recurrent Headache in Adolescents Short‐Term Outcome and Its Prediction
Authors: Larsson Bo , Melin Lennart 
Published: June 2005

SYNOPSISThe results from three separate treatment studies on adolescents (N = 108) aged 16‐18 years with predominantly recurrent tension (n = 85), and migraine (n = 23) headaches are presented along with information on predictors of short‐term outcome. A standardized therapist‐or home‐based relaxation training program was compared to attention‐control approaches in which information or problem‐discussion procedures were provided for the students. These treatment conditions were both contrasted with self‐monitoring procedures. All students were assessed and treated in a school setting and may therefore, be regarded as representing a nonclinical replication series. The outcome results indicated that the majority (53%) of students, in particular those with tension headache, had improved after both forms of relaxation training, which were clearly superior to attention‐placebo control and self‐monitoring contrasts. Furthermore, it was found that treatment condition, baseline headache severity and students' satisfaction with their home life were the strongest predictors of overall outcome, accounting for 32% of the total variance. For students provided with relaxation training, a set of four parameters, again including baseline headache severity, in addition to students' level of somatic symptoms, school satisfaction and disease within their family, emerged as strong predictors of outcome, explaining 44% of the outcome variance. The results are discussed in view of similar outcome and prediction studies in the field of pediatric and adult recurrent headache.
Brainstem Auditory Evoked Potentials (BAEPs) in Childhood Migraine
Authors: Battistella Pier Antonio , Suppiej Agnese , Casara Gianluca , Cavinato Maria Silvia , Olivotto Daniela , Pitassi Isabella , Zacchello Franco 
Published: June 2005

SYNOPSISBrainstem auditory evoked potentials (BAEPs) were recorded in pain‐free periods in 28 children suffering from migraine (23 common and 5 classic). They were without medication for at least one month before there cording session. The results were compared with a group of 10 normal subjects matched for sex and age. We found no significant differences between the migraine group and the control subjects; when analyzing separately the classic and common form, two groups either with more or less than 5 years of history of migraine or with and without nausea and/or vomiting, similar results were obtained. Our data suggest that in migrainous children conduction in the auditory pathway at the brainstem level is not significantly different from controls.
Cluster Headache Like Symptoms Due to Sinusitis: Evidence for Neuronal Pathogenesis of Cluster Headache Syndrome
Authors: Takeshima Takao , Nishikawa Seiho , Takahashi Kazuro 
Published: June 2005

SYNOPSISTwo patients with paranasal sinusitis, who showed cluster headache like symptoms rather than typical sinusitis symptoms, are reported. A possible mechanism of the cluster headache like symptoms is discussed. The importance of paranasal radiological study of patients with cluster headache like symptoms is emphasized. These cases seem to support a neuronal pathogenesis of the cluster headache syndrome.
Palliation of Pain in Advanced Oral Cancer
Authors: Narayanan R. Sankara , Nair M. Krishnan , Padmanabhan T.K. 
Published: June 2005

SYNOPSISPain is a severe symptom in advanced oral cancer. Pain is often aggravated by the anxiety induced by visible oral cancer. Unless the primary and regional disease are controlled, nothing substantial in terms of pain relief can be achieved in advanced oral cancer by methods like radiotherapy, surgery or chemotherapy. However, additional treatments such as adequate medical and psychological management may result in considerable alleviation of pain. This article emphasizes the need for more organised education of health professionals, research and publications in cancer pain relief. It also underlines the importance of adequate medical and psychological management to alleviate pain from cancer.
Aborting a Migraine Attack: Naproxen Sodium v Ergotamine plus Caffeine
Authors: Sargent Joseph D. , Baumel Barry , Peters Kenneth , Diamond Seymour , Saper Joel R. , Eisner Larry S. , Solbach Patricia 
Published: June 2005

SYNOPSISThe tolerability and efficacy of naproxen sodium and of ergotamine tartrate plus caffeine (ergotamine) were compared in the treatment of acute migraine attacks and associated symptoms. In this multicenter, double‐blind, parallel study of up to six headaches over a 3‐month period, patients took naproxen sodium 825 mg, ergotamine 2 mg, or placebo at the time of the first symptom of an attack; 30 minutes later, if necessary, patients repeated naproxen sodium 275 mg, ergotamine 1 mg or placebo, as appropriate. Rescue medication was allowed 30 minutes following the second dose if needed. Active drugs provided notably better relief of head pain than did placebo; 1 hour following the first dose the difference between naproxen sodium and placebo was statistically significant. Naproxen sodium was as efficacious as ergotamine in the relief of migraine attacks and associated symptoms. Relief of vomiting, nausea, photophobia, and motor symptoms favored naproxen sodium over ergotamine; these differences were statistically significant for nausea and motor symptoms. Ergotamine‐treated patients reported more complaints and had more severe and longer‐lasting complaints than patients on the other two regimens. Overall tolerance ratings by both investigators and patients indicated that naproxen sodium and placebo were tolerated significantly better than ergotamine.
Percutaneous Radiofrequency Trigeminal Gangliorhizolysis in Intractable Cluster Headache
Authors: Mathew Ninan T. , Hurt Wayne 
Published: June 2005

SYNOPSISRecent interest in the possible role of substance P and other vaso‐active polypeptides of the trigeminal vascular system, in the pathogenesis of vascular headache, has lad to a reconsideration of the value of ablative procedures on the trigeminal nerve in the control of chronic, medically intractable cluster headache. Twenty‐seven patients with disabling intractable chronic cluster headache underwent radiofrequency trigeminal gangliorhizolysis. Indications included total resistance to prophylactic treatment, narcotic dependency, hypercorticism, and contra‐indications to ergotamine and methysergide as a result of severe ischemic heart disease. The procedure had to be repeated in 6 patients, once in 4 and twice in 2. The average follow‐up period was 28 months with a range of 6 to 63 months. Excellent results were obtained in 15 patients, very good in 2, good in 3, fair in 1 and poor in 6. Complications were anesthesia dolorosa, stabbing pain over the vertex, ice‐pick like pain over the ipsilateral eye, transient corneal infection, transient diplopia, localized dermatosis, and recurrent stye. Complications were mild and transient in the majority of the patients, and the benefits from the surgery far outweighed the discomfort from the complications. The reasons for poor results in some patients were analyzed.It is concluded that radiofrequency trigeminal gangliorhizolysis is a reasonable alternative in patients with chronic cluster headache 1) who are totally resistant to medical treatment, 2) with a history of strictly unilateral headache, and 3) with stable personality profile and low addiction proneness.
Migraine Headaches, Migraine Equivalents and Anti‐Smooth Muscle Antibodies
Authors: Ludwig Carol Lynn , Stiller John W. , Burns Patrick J. , Phillips Terence M. 
Published: June 2005

SYNOPSISWe describe 20 patients with migraine headaches and/or migraine equivalents who had positive antinuclear antibodies (ANA) on routine laboratory screening: 17 of the 20 (85%) had elevated anti‐smooth muscle antibodies (ASMA) that were cytotoxic on Cr51 studies. No patient met criteria for defined autoimmune disorders and the remainder of an extensive autoantibody screen was unremarkable. Details of the clinical features and immunology of these patients are presented. The cytotoxicity of the ASMA suggests that they are capable of producing tissue damage and inflammation and could play a pathogenic role in the production of vascular headaches and/or central nervous system symptoms in these patients.
Psychological Assessment in Tension Headache Before and After Biofeedback Treatment
Authors: Grazzi L. , Frediani F. , Zappacosta B. , Boiardi A. , Bussone G. 
Published: June 2005

SYNOPSISThe utility of Biofeedback (BFB) techniques in the treatment of tension headache in a small group of young adult patients is demonstrated. A psychological assessment was conducted before and after the treatment: the possible effects of the treatment on some psychological aspects of personality are discussed. The eventual relationships between the clinical improvement and the decrease of muscular tension values are also considered.
Cognitive Changes of Migraineurs Receiving Biofeedback Training
Authors: Mizener Deborah , Thomas Martyn , Billings Ronald 
Published: June 2005

SYNOPSISThis study investigated change in cognitions of migraine patients as they progressed through biofeedback training. Specific cognitions investigated were beliefs about their ability to control physiological processes and their health in general, and coping strategies used.Subjects were male and female patients presenting with chronic migraine headache at Sunnybrook Medical Centre. They completed the Health Locus of Control, PSC Belief Survey and Cognitive Coping Questionnaire at three different intervals ‐ pre‐, mid‐ and post‐treatment. The results showed that patients became more internal about their beliefs to control their general health, held higher beliefs of ability to control their physiological processes, and were ignoring their pain sensations more than when they started treatment. There was a trend for patients to increase the use of coping self‐statements and to decrease catastrophizing. Interestingly, the significant change in cognitions took place between pre‐ and mid‐treatment (i.e. before biofeedback training occurred). There were some significant correlations between the cognitive and physiological measures, and headache outcome.
Hypothesis: a Rationale for Migraine
Authors: Suess Larry E. , Cuetter Albert C. 
Published: June 2005

SYNOPSISWe explore the importance certain extracranial peripheral neural structures have in the pathogenesis of the painful second phase of migraine. The role of leptomeningeal arteries in the migraine pain, and the laudatory nature of the leptomeningeal and extracranial vasodilatation responsible for the migraine phenomenon are presented. When patients understand the concept that the oligemic first phase of the attack of migraine is the actual noxious event which should be targeted for comprehensive management, they are able to improve their quest to identify precipitating environmental factors and obtain clues that will serve as guidelines in the prevention of the attacks.
Arterial Encroachment by an Electrode as a Cause of Referred Vascular Headache
Authors: Hill Stephen , King Don , Flanigin Herbert , Smith Joseph , Gallagher Brian 
Published: June 2005

SYNOPSISA case is reported of focal headache caused by traction on the left middle cerebral artery by an intracerebral electrode placed in the left amygdala. The character and location of the headache suggested the involvement of vascular structures. CT confirmed the diagnosis, and the headache was relieved by removal of the electrode. The features of pain referred from intracranial vessels are reviewed.
Episodic Cluster Headache: Short and Long Term Results of Prophylactic Treatment
Authors: de Carolis Piero , de Capoa Daniela , Agati Raffaele , Baldrati Anna , Sacquegna Tommaso 
Published: June 2005

SYNOPSISWe reviewed our experience with episodic cluster headache patients to evaluate both short and long term results of prophylactic treatment. 50 patients (46 M ‐ 4 F) with episodic cluster headache were studied. During a follow‐up period (mean duration 27.5 months, range 12–84) we studied: response to prophylactic treatment, relapses in responders, and response to the same prophylactic treatment when repeated in subsequent bouts. Drugs used were: Prednisone 50 mg/day; Nimodipine 120 mg/day; Lithium Carbonate 900 mg/day and Methysergide 6 mg/day. The patients were treated at the start of the cluster (within the first week of a bout); successful outcome was defined as the disappearance of attacks within seven days of treatment. Prednisone and Nimodipine gave positive results in over 50% of cases, Lithium Carbonate in 40% of cases, Methysergide in less than 30% of cases. Prednisone presented 33% of relapses; less relapses occurred with Lithium and Nimodipine.Treatment effectiveness tends to diminish in subsequent bouts irrespective of the drug used.
Mitochondrial Abnormalities in Migraine. Preliminary Findings.
Authors: Montagna P. , Sacquegna T. , Martinelli P. , Cortelli P. , Bresolin N. , Moggio M. , Baldrati A , Riva R. , Lugaresi E. 
Published: June 2005

SYNOPSISNine patients with migraine (5 with migraineous stroke) were investigated for defects of mitochondrial energy metabolism. During effort, blood lactate rose significantly higher in migraineurs. Muscle biopsy showed ragged‐red fibres deficient in cytochrome‐c‐oxidase activity in one case. On muscle biochemistry, depression of some respiratory chain enzymes was found for the whole group of patients, and especially in 2 for cytochrome‐c‐oxidase, succinate‐cytochrome‐c‐reductase and NADH‐cytochrome‐c‐reductase.Our findings are still preliminary, but they suggest impaired mitochondrial energy metabolism in migraine.
Intracranial Haemodynamics in Cluster Headache
Authors: Gawel M.J. , Krajewski A. 
Published: June 2005

SYNOPSISIt is now possible to obtain information about intracranial blood flow velocity by the use of transcranial doppler. We investigated transcranial doppler flow velocities in 42 cluster headache patients, and 41 controls. Interhemispheric asymmetry was significantly greater in the cluster headache group. Within the patient groups, velocities in the middle cerebral artery and posterior cerebral artery, were significantly faster on the headache side and slower in the anterior cerebral artery.Prophylactic medication seems to block these changes.
Interhemispheric Attentional Functioning in Classic Migraine Subjects During Paroxysmal and Interparoxysmal Phases
Authors: Mazzucchi A. , Sinforiani E. , Zinelli P. , Agostinis C. , Granella F. , Miari A. , Manzoni G.C. , Parma M. 
Published: June 2005

SYNOPSISTo investigate whether recurrent neurological migraine prodromes may cause deterioration of higher brain functions, classic migraine patients with prodromes always on the same side ware submitted versus controls to a lateralized attentional task (Posner's test) at a short time interval from the headache attack (paroxysmal phase) and at a longer interval during the headache‐free period (interparoxysmal phase). The results indicate that classic migraine subjects showed no significant changes of interhemispheric attentional processing and interhemispheric balance. Some other findings which did not regard interhemispheric balance are discussed.
The Hypnic Headache Syndrome
Authors: Raskin Neil H. 
Published: June 2005

SYNOPSISSix patients, all but one, men, between the ages of 65 and 77 years, were regularly awakened from sleep at a consistent time of night, sometimes during a dream, by a diffuse headache that persisted for 30 to 60 minutes and was often associated with nausea, without autonomic symptoms. In all cases, headache ceased or was substantially attenuated by a bedtime dose of 300 to 600 mg of lithium. The disorder persisted for one and a half to three years in three of the patients; the others continue to require lithium. It is proposed that this syndrome may be caused by perturbation of a biological clock.
Treatment Review: Non‐Steroid Anti‐Inflammatory Drugs in the Treatment and Long‐Term Prevention of Migraine Attacks
Authors: Pradalier A. , Clapin A. , Dry J. 
Published: June 2005

SYNOPSISAfter reviewing the pathophysiological features suggesting a role of prostaglandins in migraine, we have analyzed the literature concerning double‐blind trials of anti‐inflammatory drugs versus placebo or reference compounds in the acute and long‐term preventive treatment of migraine. For both of these indications, in the majority of double‐blind trials NSAID's have been found to be superior to placebo and equivalent to reference drugs. Certain points remain to be defined including, in particular, the following: • acceptability in the long‐term or by frequent repeated administrations, • efficacy according to different types or factors inducing migraine. More extensive trials are therefore indicated.
Epidemiology of Migraine: A Survey in 21 Provinces of the People's Republic of China, 1985
Authors: Zhao Fu , Tsay Jia‐Yeong , Cheng Xue‐ming , Wong Wu‐ji , Li Shi‐chuo , Yao Shui‐xiang , Chang Si‐ming , Schoenberg Bruce S. 
Published: June 2005

SYNOPSISThe first large scale study of migraine epidemiology from a nationwide collaborative group was carried out in 22 Chinese rural and ethnic minority communities of 21 provinces of the People's Republic of China during 1985 in a well‐defined population of 246,812 inhabitants. On the day for which prevalence was calculated, January 1, 1985, there were 1703 cases of migraine, yielding a point prevalence ratio of 690/100,000. The prevalence ratio of migraine for females was higher than that for males. The overall sex difference in the prevalence ratio was significant (Z=26.57, P<0.0001), The prevalence began from the age before 10 years old, and monotonically increased until it had reached its peak at age 40–49, then decreased steadily. The geographic distribution of the prevalence has the tendency that the south is higher than the north, and the west is higher than the east. The incidence rate of new cases was 37/100,000 in 1984. The incidence rate reached its peak at age 15–19, then gradually decreased. Incidence before age 10 and after age 50 was rare. The incidence rate of migraine was higher in females than in males. Sex difference in the incidence rate was significant (Z=4.35, P<.0001}. Clinical Manifestations: In 804 cases with auras, 793 (46.56%) had visual disturbances, 11 (0.64°/o) had hemiparesis or hemiparesthesia. Concomitant nausea or vomiting occurred in 1,349 cases (79.21%). Among those 1703 cases with headache, 584 cases (34.29%) were unilateral, 791 cases (40.45%) were bilateral and 328 cases (19.26%) were uncertain. In duration of headache, 744 cases (43.69%) had less then 24 hours and 720 cases (42.28%) had 24 hours or longer. In the frequency of episodes, 818 cases (48.03%) had no more than once per month and 742 cases (43.57%) had more than once per month. Classification: There were 752 cases (44.16%) of prodromal type (classical) migraine, 929 cases (54.55%) of non‐prodromal type (common) migraine, 14 cases (0,82%) of cluster headache, 2 cases (0.12%} of hemiplegic migraine. Each of vertebrobasilar and ophthalmoplegic types had 3 cases (0.18%), Trigger Factors for Episodes: 678 cases (39.81%) were triggered by mental stress (tension, anxiety etc.), 509 cases (29.81%) by change of weather and 293 cases (20.88%) of females by menstruation.
Platelet Alpha2‐Adrenoceptor Binding in Migraine
Authors: Hasselmark Lena , Malmgren Rigmor , Hannerz Jan 
Published: June 2005

SYNOPSISPlatelet alpha 2 ‐adrenoceptor binding was determined in ten migraine patients and sixteen healthy controls using (3H)‐yohimbine as radioligand. The mean value of maximum binding (Bmax ) in the migraine patients was 133 ±55 binding sites/ platelet which is significantly lower than that of 217 ± 76 binding sites/platelet in controls (p<0.01). There was also a significant difference in the mean dissociation constant (KD ); 2.05 ± 0.44 nM in migraineurs and 2.98 ± 1.15 nM in controls (p<0.05). Platelet alpha 2 ‐adrenoceptors may constitute valid models for certain characteristics of alpha 2 ‐adrenoceptors in the brain. An alteration in platelet alpha2 ‐adrenoceptor binding may thus reflect similar alterations in central alpha2 ‐adrenoceptors. It is also discussed whether the alpha2 ‐adrenoceptor abberrations are intrinsic to migraine or a result of endogenous and/or pharmacologically induced modulation.