bluuebunny/crossref_metadata_2025_split huggingface dataset:
The relationship between the occurrence of asthma and diabetes among a sample of patients attending Damascus Hospital
Authors: Ghazi Ahmad , Zouhaily Sara Al , Bardan Housam 
Published: January 2024

Abstract

Introduction:
Diabetes is a major public health problem, and there is a continuing increase in the incidence and long-term complications. These complications are mainly sequelae of microvascular destruction in target organs. Many lung injuries occur in the context of diabetes due to the presence of abundant microcirculation and abundance of tissues. Macrophages, raising the possibility that lung tissue is a target organ in patients with diabetes.
Research objectives:
This research was designed to study the effect of diabetes, both the duration of infection with this disease, and control of diabetic status on lung function and the incidence of asthma.
Methods and materials:
A cross-sectional study, conducted on 100 diabetic patients attending Damascus Hospital in the period between 1/1/20217 and 1/1/2023. It was compared with a control group consisting of 100 healthy individuals without diabetes. It was recorded. Hemoglobin, fasting blood sugar, and a lung function test (spirometry) were measured for all participants in the study, and the following lung measurements were taken: maximum expiratory volume in the first second (FEV1), forced vital capacity (FVC), ratio (FEV1/FVC). Analyze the results using: mean + standard deviation, Pearson's chi-square, Pearson's correlation coefficient, and ANOVA test.
Results
The average percentage of expected FEV1 and expected FVC in people with diabetes is lower compared to healthy non-diabetic controls (p smaller than 0.05), and these values were lower in patients without controlled blood sugar compared to patients with controlled blood sugar, and the values were also lower in patients with diabetes for a longer period of time, these values were lower in patients with type 1 diabetes, and all previous criteria led to the occurrence of asthma.
Conclusion
The findings in this study suggest that the lung is a target organ for diabetes, and that diabetic patients have a decline in lung function and the incidence of asthma compared to non-diabetics in a blockade lesion model. Lung function deteriorates the longer the duration of diabetes and the longer the diabetes is uncontrolled.
Long-term results of anti-VEGF therapy in macular edema caused by central retinal vein occlusion
Authors: Galimova A. B. , Galimova V. U. 
Published: January 2024

Purpose. To evaluate long-term results of anti-VEGF therapy performed in a modified “treat-and-extend” regimen in macular edema secondary to central retinal vein occlusion.Material and methods. The prospective study included 29 patients (16 men and 13 women) aged 24–81. The median follow-up period was 36 months [24; 60]. 20 patients underwent ranibizumab monotherapy, 3 patients – aflibercept monotherapy, while 6 patients received a combination of the two drugs following the modified regimen, which allowed terminating anti-VEGF treatment when macular edema remission was achieved.Results. Macular edema completely resolved in 27 out of 29 patients (93.1%) by the end of the second year, while the remaining 2 patients showed the complete resolution during the third year. 18 patients (62.1%) could terminate anti-VEGF therapy during the first 6 months, whereupon they received 3 to 5 monthly injections with no macular edema relapse over the subsequent 21–22 months of the follow-up. 11 patients continued anti-VEGF therapy and averagely received 7.09 ± 1.14, 5.09 ± 2.34 and 2.18 ± 2.36 injections with individually determined intervals at years 1, 2 and 3, respectively. On the whole, 22 patients (75.9%) terminated anti-VEGF therapy and transferred to drugless observation at the end of year 2, while 5 other patients (17.2%) terminated anti-VEGF therapy during year 3. As a result of the treatment, the maximum BCVA improved from 0.15 [0.07; 0.3] to 0.7 [0.4; 0.9] by the end of year 1 (Z = -4.69; p = 0.0000027) and remained stable during the rest of the follow-up.Conclusion. Anti-VEGF therapy in modified treat-and-extend regimen is effective in macular edema secondary to central retinal vein occlusion. and results in a significant and sustainable visual acuity gain and complete resolution of macular edema with a minimum quantity of injections in most patients.
Using a solid-phase variant of enzyme immunoassay for the etiological diagnosis of endogenous uveitis
Authors: Kon’kova A. Yu. , Horowitz E. S. , Gavrilova T. V. , Chereshneva M. V. , Afanasievskaya E. V. 
Published: January 2024

Enzyme-linked immunosorbent assay (ELISA) has traditionally been used to diagnose infectious diseases, including ophthalmic ones. As a rule, however, investigators are only focused on differentiated detection of specific immunoglobulins (Ig) of varied classes, despite the fact that ELISA is able to register a wider range of emerging immune responses.Our purpose is to assess the effectiveness of the solid-phase version of ELISA for the etiological diagnosis of endogenous uveitis.Material and methods. 107 patients (114 eyes) aged 19 to 83 (ave. 45.2 ± 2.8 yrs) with various clinical forms of endogenous uveitis were examined by the traditional ELISA method. Along with the detection of specific Ig, the avidity of IgG and “paired” sera were studied.Results. In the primary serological examination, specific IgG were found in almost all patients (to herpes simplex viruses in 100 %, and to cytomegaloviruses in 96,3 %). Specific IgM were revealed in 3.7 % of cases. Specific IgG to T. gondii were found in 44.9 % of the patients and in 2 people, IgM. Specific IgG to C. trachomatis were found in 23 patients, and in two cases, IgM. By studying the avidity of antibodies, etiology was additionally deciphered in 1.9 % of patients. The study of “paired” sera helped determine the etiology of the disease in another 16 people.Conclusion. An integral approach using all diagnostic capabilities of ELISA, in particular the differentiated definition of specific Ig of various classes and the avidity of specific IgG, as well as the study of “paired” sera, made it possible to significantly increase the diagnostic capabilities of ELISA. As a result, the etiology was deciphered in 26 patients (24,3 %).
Using a new antiallergic drug Epinepta® in the treatment of seasonal allergic conjunctivitis. Clinical cases
Authors: Yani E. V. 
Published: January 2024

Purpose: to evaluate the effect of a new antiallergic drug epinastine in the treatment of seasonal conjunctivitis as manifested in clinical cases.Materials and methods. 37 people (22 men and 15 women) were observed during spring exacerbation of the allergic conjunctivitis, from mid-March to the end of June. Indicators of the dynamics of subjective complaints, duration of treatment, clinical effectiveness, were thoroughly recorded; we also assessed how easy it was to stop using the treatment when the condition of the ocular surface returned to normal.Results. We identified four groups of patients depending on the course of the disease, clinical manifestations, and response to epinastine therapy. For each group, we analyze a most informative clinical case.Conclusions. In all of the cases, epinastine instillations brought about a quick and stable reduction of itching and eye discomfort, as well as normalization of the clinical condition of the conjunctiva.
Modern diagnostic potentials of studying structural and functional changes of the retina and the optic nerve in multiple sclerosis patients
Authors: Fursova A. Zh. , Zubkova M. Yu. , Vasilyeva M. A. , Gamza Yu. A. , Malkova N. A. , Prokaeva A. I. , Rabota F. K. 
Published: January 2024

Purpose: to study significant functional and structural changes in the retina and the intraocular section of the optic nerve in multiple sclerosis (MS) patients and analyze how they are interrelated with electrophysiological changes in the visual analyzer.Materials and methods. The study included 44 patients (88 eyes): group 1 (26 eyes) with MS duration ≤ 5 years and no history of optic neuritis (ON); group 2 (30 eyes) with MS duration from 6 to15 years and no history of ON; and group 3 (32 eyes) with MS duration ≤ 15 years with a history of ON. All patients underwent a complete ophthalmological examination and optical coherence tomography and had visually evoked potentials (VEP) and static automated perimetry registered.Results. A decrease in functional and structural parameters progressing with the duration of MS was revealed. In particular, best corrected visual acuity (BCVA) fell to 0.860 ± 0.075, the photosensitivity index MD maximally fell to -3.78 ± 0.95 dB, the strength of the P100 wave amplitude dropped to 7.84 ± 2.98 μV, the latency index of VEP rose to 124.21 ± 1.36 ms, the thickness of GCL + IPL fell to 65.69 ± 7.85 μm, and RNFL thickness averagely fell a low as to 80.25 ± 8.81 μm. When analyzing the topography of GCL + IPL decrease by sectors, the maximum value was revealed in the upper temporal segment (67.63 ± 7.89 μm). Sectoral changes in RNFL arranged in descending order of thickness showed the following sequence: lower upper nasal temporal. As the disease progressed, structural and functional changes were accompanied by an increase in the depth and a decrease in the thickness of the lamina cribrosa, with a maximum value revealed in the group with prior ON (239.00 ± 11.93 μm). Strong correlations were found in all study groups between (1) ave. GCL + IPL and ave. RNFL (r = 0.69; 0.64; 0.88, p < 0.03), (2) ave. GCL+IPL and BCVA (r = 0.86; 0.75; 0.78, p < 0.05), (3) MD and ave GCL + IPL (r = 0.52; 0.69; 0.71, p < 0.03), and (4) MD and ave. RNFL (r = 0.67; 0.61; 0.66, p < 0.05), as well as between the parameters of the lamina cribrosa and the markers under study.Conclusion. Significant functional and structural changes in the retina and the optic nerve were detected, correlating with the duration of the disease and with the clinical features of the course of multiple sclerosis. The presence of ON in history was accompanied by more pronounced changes, which can be considered as an important additional aggravating factor of the disease.
Staropolskie refleksje na temat wolności i niewoli – z perspektywy chrześcijańskiej moralistyki (na wybranych przykładach)
Authors: Ryba Renata 
Published: January 2024

W dotychczasowych badaniach nie podejmowano, jako osobnego zagadnienia, obecnego w literaturze dawnej problemu wolności i niewoli narodowej z perspektywy winy i kary. Tymczasem w refleksji moralistów doby staropolskiej był to istotny wątek myślowy. W piśmiennictwie ujmowano zjawisko niewoli w ramach Boskiego wymiaru sprawiedliwości. Wskazywano na zależność między grzechem a karą, wymierzaną przez Boga całym społecznościom. Niewola i wolność były rozumiane jako wyraz działania Boga w historii. Moraliści stawiali sobie dwa cele: przestrzec polskie społeczeństwo przed możliwą utratą niepodległości na skutek grzesznego zachowania, a przy tym zachęcić do moralnej poprawy i tym samym – zapobiec katastrofie.
Deep Learning-based Glaucoma Detection Using CNN and Digital Fundus
Images: A Promising Approach for Precise Diagnosis
Authors: Song Ruiying , Wang Hong , Xing Yinghua 
Published: January 2024

Background::
Glaucoma is a significant cause of irreversible blindness worldwide, with symptoms often going undetected until the patient's visual field starts
shrinking.

Objetive::
To develop an AI-based glaucoma detection method to reduce glaucoma-related blindness and offer more precise diagnosis.

Methods::
Discusses various methods and technologies, including Heidelberg Retinal Tomography (HRT), Optical Coherence Tomography (OCT), and
Fundus Photography, for obtaining relevant information about the presence of glaucoma in a patient. Additionally, it mentions the use of Support
Vector Machines (SVMs) and Convolutional Neural Networks (CNNs) for glaucoma detection. There are many limitations for existing methods
as; Asymptomatic Progression, reliance on subjective feedback, multiple tests required, late detection, limited availability of preventive tests,
influence of external factors.

Results::
Findings reveal promising outcomes in terms of glaucoma detection accuracy, particularly in the analysis of the RIM-ONE-r3 dataset. By
scrutinizing 20 images from the Healthy, Glaucoma, and Suspects categories through fundus image recognition, our developed AI model
consistently achieved high diagnostic accuracy rates.

Conclusion:
Our study suggests that further enhancements in glaucoma detection accuracy are attainable by augmenting the dataset with additional labeled
images. We emphasize the significance of considering various application parameters when discussing the integration of computer-aided
decision/management systems into healthcare frameworks.
Reproducing the present-day mantle structure using forward mantle convection models since the Cretaceous
Authors: Pal Debanjan , Ghosh Attreyee 
Published: January 2024

Seismic tomography models show distinct slab structures at different
subduction zones and the dominance of degree-2 mantle structure near the
core-mantle boundary (CMB). In order to understand how the observed
present-day mantle structure came into being, we employ plate-motion
history starting from 140 Ma till the present day in global mantle
convection models. We tune model parameters such as the effect of
different viscosities in the weak layer below 660, weaker asthenosphere
and slabs, internal heat generation rate, Clapeyron slope and density
change across 660, density and viscosity of thermochemical piles above
the CMB, and model duration, to investigate their effect on the
predicted mantle structure. We do a quantitative comparison with the
predicted present-day mantle structure from our convection models and
the seismic tomography models S40RTS and TX2019S, using the long
wavelength geoid anomaly as an additional constraint. We find that
distinct and linear slab structures are generated when the asthenosphere
is moderately weak and stronger slabs are present. The slabs also need
to be strong enough since as they sink into the mantle, they sweep the
Large Low Shear Velocity provinces (LLSVPs) underneath Africa and the
Pacific and generate plumes along their edges. The shape and location of
our predicted LLSVPs and slabs are consistent with those in the
tomography models. Some of the predicted plume locations are consistent
with the real Earth hotspot locations, although the plume structures do
not match those in the tomography models. We find that these predicted
plumes are integral in fitting the geoid at the intermediate
wavelengths. Introducing a moderate Clapeyron slope (-2.5 MPa/K) at 660
does not drastically affect the predicted slab structure. A stronger
negative Clapeyron slope resists mass transfer across 660, causing
widespread slab stagnation and stalling of plumes at this discontinuity.
The predicted present-day mantle structure and the geoid are similar
in thermal or thermochemical cases with slightly dense LLSVPs. However,
making the LLSVPs highly viscous or more dense hinders plume generation
and degrades the fit to the observed geoid. Through this modelling
effort, we attempt to constrain the values of various parameters that
have an effect on the predicted mantle structure.
SOSIALISASI CHSE (CLEANLINESS, HEALTH, SAFETY & ENVIRONMENTAL SUSTAINABILITY) DALAM TATA KELOLA HOMESTAY PADA MASA PANDEMI DI DESA WISATA ALAMENDAH, BANDUNG
Authors: Karyani Tuti , Djuwendah Endah , Supriyadi Ery , Hasbiansyah O , Mutiarasari Nurul Risti 
Published: January 2024

Masa pandemi covid-19 masih belum berakhir, walaupun sudah mulai terjadi penurunan. Kegiatan masyarakat sudah mulai menggeliat termasuk sektor parawisata, sehingga untuk mengantisipasinya yaitu melalui penerapan CHSE (cleanliness, Health, Safety and Environmental Sustainability) yang diawali dengan adanya sosialisasi. Sosialisasi CHSE diberikan ke pengelola/pemilik homestay dan stakeholder lain di desa wisata Alamendah. Homestay di desa wisata Alamendah ada 3 type yaitu homestay dengan halaman luas, homestay di pinggir jalan dan homestay di tengah perkampungan penduduk. Hasil pelatihan menunjukkan bahwa terjadi peningkatan pengetahuan dan sikap pengelola/pemilik homestay mengenai CHSE namun dalam implementasinya pada ketiga type homestay masih belum sepenuhnya diterapkan dengan alasan karena wisatawan yang menginap belum banyak. Diharapkan penerapan CHSE ini menjadi kebiasaan baru dalam pengelolaan homestay sebagai salah satu daya tarik bagi wisatawan
PENINGKATAN KAPASITAS PETANI PENGELOLA AGROWISATA DALAM MENDUKUNG AGROWISATA BERKELANJUTAN
Authors: Djuwendah Endah 
Published: January 2024

Agrowisata merupakan sebuah bentuk kegiatan pariwisata yang memanfaatkan usaha pertanian (agribisnis) sebagai objek wisata dengan tujuan untuk memperluas pengetahuan, pengalaman, rekreasi, dan hubungan usaha dibidang pertanian. Desa Cibodas Kecamatan Lembang merupakan salah satu sentra produksi pertanian dan destinasi wisata yang banyak diminati oleh para wisatawan yang berada di Kabupaten Bandung Barat . Agrowisata di desa Cibodas dikelola oleh kelompok tani dan kelompok wanita tani.dalam skala usaha relatif kecil dan belum dikelola secara optimal. Oleh karena itu perlu adanya peningkatan kemampuan pengelola agrowisata dalam memanfaatkan peluang dan potensi agrowisata di desa Cibodas guna tercapainya agrowisata berkelanjutan. Kegiatan ini berbentuk action research dengan tujuan mengetahui profil agrowisata dan meningkatkan kapasitas pengelola agrowisata dalam mengemas paket agrowisata yang memperhatikan kaidah konservasi lingkungan serta pemanfaatan teknologi informasi dan komunikasi dalam promosi wisatanya. Hasil kegiatan PKM menunjukkan profil agrowisata sebagian besar usaha komunitas yang mengusahakan komoditas beragam dengan aktifitas eduwisata dan swafoto. Penyuluhan dalam bentuk webinar dapat meningkatkan pengetahuan dan kesadaran petani pengelola agrowisasta untuk meningkatkan implementasi sapta pesona wisata, pengelolaan homestay, etika komunikasi lingkungan dalam mengemas dan mempronosikan agrowisata serta ekonomi kreatif sebagai faktor pendukung pengembangan agrowisata berkelanjutan.
IMPLEMENTASI PROGRAM POJOK DIGITAL DALAM MENUNJANG KEGIATAN UMKM DI DESA SUKAMAJU KABUPATEN SUMEDANG
Authors: Mauludin Mochamad Ali 
Published: January 2024

Pengabdian dilakukan di Desa Sukamaju Kecamatan Rancakalong Kabupaten Sumedang berupa pendampingan dalam pendirian pojok digital. Pojok digital merupakan program dari pemerintah Kabupaten Sumedang dan Universitas Padjadjaran dimana merupakan suatu tempat atau wadah dalam mengoptimalkan peran teknologi dan informasi yang terkoordinir dan bermanfaat untuk kemajuan UMKM. Tujuan kegiatan ini adalah pertama, mendirikan pojok digital di salah satu tempat di wilayah desa Sukamju, kedua, mendata UMKM yang ada di desa Sukamaju baik yang berupa olahan pangan atau kuliner, adibusana dan Agribisnis, dan ketiga, mengoptimalkan peran UMKM untuk lebih baik mulai dari administrasi hingga penjualan. Metode penerapan pengabdian dilakukan melalui pendampingan dan sosialisasi kepada UMKM, Perangkat Desa, dan Tokoh Masyarakat. Kegiatan pengabdian yang berlangsung dari bulan November – Desember tahun 2021 memberikan gambaran yaitu penyampaian sosialisasi terkait berdirinya pojok digital, berdirinya pojok digital serta aktivitasnya dalam mengelola UMKM menjadi lebih baik.
PEMANFAATAN LAHAN PEKARANGAN DENGAN BERCOCOK TANAM SAYURAN DI DESA MEKARJAYA KABUPATEN BANDUNG
Authors: Farida Farida , Suminar Erni , Budiarto Rahmat 
Published: January 2024

Desa Mekarjaya berada di kawasan Kabupaten Bandung dengan wilayah pertanian cukup luas. Masa pandemik saat ini menyebabkan aktivitas di luar rumah menjadi terbatas, sebegian besar kegiatan dilakukan secara daring (online). Salah satu kegiatan yang dapat dilakukan tanpa daring yaitu bercocok tanam di pekarangan sekitar rumah. Sayuran merupakan salah satu komoditas yang diperlukan sehari-hari untuk dikonsumsi warga, oleh karena itu sangat tepat apabila pekarangan rumah dimanfaatkan untuk kegiatan bercocok tanam sayuran. Sayangnya informasi dan pengetahuan tentang bercocok tanam masih kurang maksimal (data hasil survey). Berdasarkan data tersebut kami melaksanakan kegiatan pengabdian kepada warga desa Mekarjaya melalui organisasi Pemberdayaan Kesejahteraan Keluarga (PKK) setempat. Sosialisasi kegiatan ini menggunakan metode penyuluhan secara daring dan praktek langsung di pekarangan/lahan warga (demonstration plot). Disamping itu, warga yang berpartisipasi sebagai peserta penyuluhan juga diberikan benih bersertifikat yang memiliki daya tumbuh yang baik. Kegiatan ini bertujuan untuk membeikan motivasi dalam melakukan bercocok tanam sayuran yang dapat dikonsumsi langsung atau dijual sebagai sumber pendapatan tambahan. Hasil kegiatan menunjukkan bahwa adanya respon yang positif terlihat dari minat dan ketertarikan ibu-ibu PKK Desa Mekarjaya dalam bercocok tanam sayuran.
REFRESING KADER DETEKSI DINI & INTERVENSI STUNTING SEBAGAI UPAYA PENURUNAN PREVALENSI STUNTING DI DESA SAYANG KEC. JATINANGOR KAB. SUMEDANG
Authors: Didah Didah 
Published: January 2024

Abstrak Pemberdayaan masyarakat melalui kader kesehatan sangat penting dalam menurunkan prevalensi stunting karena kader berperan penting dalam penggerak posyandu. Peran kader di setiap wilayah desa nya sangat berpengaruh karena kader haruslah mampu berperan aktif dalam upaya penurunan prevalensi stunting. Kader menjadi salah satu ujung tombak pelayanan kesehatan di komunitas di ranah promotif dan preventif, yang fungsinya adalah sebagai wadah untuk mendekatkan pelayanan kesehatan dasar. Adapun tujuan dari kegiatan pengabdian kepada masyarakat ini adalah untuk meningkatkan pengetahuan kader tentang deteksi dini dan intervensi stunting sebagai upaya pengentasan prevalensi stunting di Desa Sayang Kecamatan jatinangor Kabupaten Sumedang. Sasaran kegiatan ini adalah kader yang berada di desa sayang dengan jumlah peserta sebanyak 26 orang. Kegiatan refresing kader menggunakan metode ceramah tanya jawab online di lanjutkan dengan sesi tanya jawab serta diskusi. Hasil PKM ini di dapat kan peningkatan pengetahuan yang signifikan sebelum dan setelah di berikan intervensi. Sebelum mengikuti kelas refreshing pengetahuan kader sebagian besar masih dalam kategori kurang yaitu sebesar 58% dan setelah dilakukan kelas refreshing kader pengetahuan kader meningkat menjadi kategori baik yaitu sebesar 77%. Hal ini membuktikan bahwa kelas refreshing kader berpengaruh terhadap peningkatan pengetahuan kader. Diharapkan kader dapat melakukan deteksi dini dan intervensi pengentasan stunting di wilayah nya sehingga prevalensi stunting akan menurun. Kata Kunci: Pengetahuan, Kader, Stunting