bluuebunny/crossref_metadata_2025_split huggingface dataset:
Complete Glucose Electrooxidation Enabled by Coordinatively Unsaturated Copper Sites in Metal–Organic Frameworks
Authors: Shi Xiaoyue , Ling Yiqi , Li Youcong , Li Guanhua , Li Juan , Wang Lingwei , Min Fanhong , Hübner René , Yuan Shuai , Zhan Jinhua , Cai Bin 
Published: November 2023

AbstractThe electrocatalytic oxidation of glucose plays a vital role in biomass conversion, renewable energy, and biosensors, but significant challenges remain to achieve high selectivity and high activity simultaneously. In this study, we present a novel approach for achieving complete glucose electrooxidation utilizing Cu‐based metal‐hydroxide‐organic framework (Cu‐MHOF) featuring coordinatively unsaturated Cu active sites. In contrast to traditional Cu(OH)2 catalysts, the Cu‐MHOF exhibits a remarkable 40‐fold increase in electrocatalytic activity for glucose oxidation, enabling exclusive oxidation of glucose into formate and carbonate as the final products. The critical role of open metal sites in enhancing the adsorption affinity of glucose and key intermediates was confirmed by control experiments and density functional theory simulations. Subsequently, a miniaturized nonenzymatic glucose sensor was developed showing superior performance with a high sensitivity of 214.7 μA mM−1 cm−2, a wide detection range from 0.1 μM to 22 mM, and a low detection limit of 0.086 μM. Our work provides a novel molecule‐level strategy for designing catalytically active sites and could inspire the development of novel metal–organic framework for next‐generation electrochemical devices.
Discovery of a Potent Proteolysis Targeting Chimera Enables Targeting the Scaffolding Functions of FK506‐Binding Protein 51 (FKBP51)
Authors: Geiger Thomas M. , Walz Michael , Meyners Christian , Kuehn Angela , Dreizler Johannes K. , Sugiarto Wisely O. , Maciel Edvaldo V. S. , Zheng Min , Lermyte Frederik , Hausch Felix 
Published: November 2023

AbstractThe FK506‐binding protein 51 (FKBP51) is a promising target in a variety of disorders including depression, chronic pain, and obesity. Previous FKBP51‐targeting strategies were restricted to occupation of the FK506‐binding site, which does not affect core functions of FKBP51. Here, we report the discovery of the first FKBP51 proteolysis targeting chimera (PROTAC) that enables degradation of FKBP51 abolishing its scaffolding function. Initial synthesis of 220 FKBP‐focused PROTACs yielded a plethora of active PROTACs for FKBP12, six for FKBP51, and none for FKBP52. Structural analysis of a binary FKBP12:PROTAC complex revealed the molecular basis for negative cooperativity. Linker‐based optimization of first generation FKBP51 PROTACs led to the PROTAC SelDeg51 with improved cellular activity, selectivity, and high cooperativity. The structure of the ternary FKBP51:SelDeg51:VCB complex revealed how SelDeg51 establishes cooperativity by dimerizing FKBP51 and the von Hippel‐Lindau protein (VHL) in a glue‐like fashion. SelDeg51 efficiently depletes FKBP51 and reactivates glucocorticoid receptor (GR)‐signalling, highlighting the enhanced efficacy of full protein degradation compared to classical FKBP51 binding.
Tetra‐ and Hexavalent Siglec‐8 Ligands Modulate Immune Cell Activation
Authors: Conti Gabriele , Bärenwaldt Anne , Rabbani Said , Mühlethaler Tobias , Sarcevic Mirza , Jiang Xiaohua , Schwardt Oliver , Ricklin Daniel , Pieters Roland J. , Läubli Heinz , Ernst Beat 
Published: November 2023

AbstractCarbohydrate‐binding proteins are generally characterized by poor affinities for their natural glycan ligands, predominantly due to the shallow and solvent‐exposed binding sites. To overcome this drawback, nature has exploited multivalency to strengthen the binding by establishing multiple interactions simultaneously. The development of oligovalent structures frequently proved to be successful, not only for proteins with multiple binding sites, but also for proteins that possess a single recognition domain. Herein we present the syntheses of a number of oligovalent ligands for Siglec‐8, a monomeric I‐type lectin found on eosinophils and mast cells, alongside the thermodynamic characterization of their binding. While the enthalpic contribution of each binding epitope was within a narrow range to that of the monomeric ligand, the entropy penalty increased steadily with growing valency. Additionally, we observed a successful agonistic binding of the tetra‐ and hexavalent and, to an even larger extent, multivalent ligands to Siglec‐8 on immune cells and modulation of immune cell activation. Thus, triggering a biological effect is not restricted to multivalent ligands but could be induced by low oligovalent ligands as well, whereas a monovalent ligand, despite binding with similar affinity, showed an antagonistic effect.
A study on melt spinning of polyethylene terephthalate filament yarns containing various concentrations of synthesized CuO nanoparticles
Authors: Heydari Sepide , Tavanaie Mohammad Ali , Montazer Majid , Mahmoudi‐Rad Mahnaz 
Published: November 2023

AbstractIn this research the CuO nanoparticles were synthesized with four different methods then used to produce polyethylene terephthalate (PET) fibers with antibacterial, antifungal, and photocatalytic properties during the melt spinning process. Nanoparticles were synthesized in different ways using copper acetate salt (Cu(CH3COO)2) and sodium hydroxide (NaOH). The synthesis of copper oxide (CuO) nanoparticles was confirmed by field‐emission scanning electron microscopy (FE‐SEM images), EDX patterns, TGA, FTIR, X‐ray diffraction pattern XRD, and UV‐vis absorption spectrum. The results showed that synthesized nanoparticles exhibited strong antibacterial activity against gram‐positive and gram‐negative bacteria. Finally, after examining the fibers with different percentages of nanoparticles), fibers containing 1% of nanoparticles were produced using a 20% nanocopper oxide masterbatch as the optimal sample. The presence of nanoparticles in the fiber structure was confirmed by FE‐SEM images, EDX, XRD, and FTIR analysis. Furthermore, the tensile properties, thermal behavior, and photocatalytic properties of the fibers were investigated. Evaluation of the antibacterial and antifungal activity of the produced fibers against gram‐positive bacteria Staphylococcus aureus and Candida albicans fungus showed about 90% death of bacteria and fungi.
Effects of subphase pH and temperature on the interfacial behavior of double hydrophilic diblock copolymer PDEGMA‐b‐PDIPAEMA
Authors: Li Jian , Wen Gangyao , Selianitis Dimitrios , Pispas Stergios , Zhang Yu , Li Hongfei 
Published: November 2023

AbstractThe aggregation behavior of two pH‐ and temperature‐responsive diblock copolymers of poly[di‐(ethylene glycol) methyl ether methacrylate]‐block‐poly[2‐(diisopropylamino) ethyl methacrylate] (PDEGMA‐b‐PDIPAEMA) at the air/water interface and the structures of their Langmuir–Blodgett (LB) films were studied by the Langmuir monolayer technique and atomic force microscopy, respectively. At the air/water interface, PDEGMA‐b‐PDIPAEMA tends to form the core‐shell‐corona micellar structure composed of a PDIPAEMA main chain core, an amino ethyl ester shell, and a PDEGMA corona. Under acidic, neutral, and alkaline conditions, PDIPAEMA blocks are completely protonated, partially protonated, and completely non‐protonated, respectively, and the protonated amino ethyl ester groups are immersed in water before monolayer compression, whereas PDEGMA coronas are adsorbed at the interface. At pH 3, 7, and 10, the limiting areas (A0) for PDEGMA42%‐PDIPAEMA58% (weight percents) and PDEGMA55%‐PDIPAEMA45% are 8.2/10.2/14.0 and 6.7/8.3/8.4 nm2, respectively. The A0 values of the former copolymer are larger than those of the latter. This is because the shells in the former copolymer are denser due to the higher polymerization degree of PDIPAEMA blocks, providing greater steric hindrance for PDEGMA coronas and making the latter more extended at the interface. In contrast to other copolymer systems, the effect of temperature on the isotherms of PDEGMA‐b‐PDIPAEMA is less obvious.
The elusive scleral cartilages: Comparative anatomy and development in teleosts and avians
Authors: Franz‐Odendaal Tamara A. 
Published: November 2023

AbstractThe sclera of all vertebrate eyes is comprised of connective tissue, with some organisms developing cartilage within this tissue. A review of the cartilages that have been described in the vertebrate sclera and their anatomical relationships is discussed together with their potential homology. Incorrect terminology erroneously implies similarity in location, development, morphology, and evolution, which may lead some scientists to assume all cartilages in orbit are the same elements when reading the literature. Therefore, new terminology to distinguish the different types of cartilage associated with the vertebrate eye is proposed. The scleral cartilages that are likely homologous to one another and which are situated in the sclera, should be termed scleral cartilages sensu stricto, while other cartilages in the sclera should be termed ocular cartilages. Some of the cartilages also ossify, and these bones should be distinguished from the scleral ossicles. The plasticity of the scleral tissue layer and its range of morphologies from fibrous to cartilaginous connective tissue across different vertebrate lineages are also described. This review also highlights several gaps in our understanding of the vertebrate scleral cartilages, in particular.
Anatomy in the metaverse: Exploring student technology acceptance through the UTAUT2 model
Authors: Kalınkara Yusuf , Özdemir Oğuzhan 
Published: November 2023

AbstractThe impact of technology on educational domains has been a subject of research for many years. Therefore, understanding how students perceive and utilize technologies for educational purposes is crucial. Especially in a critical subject like anatomy education, it is essential to employ various models to determine students' technology acceptance and usage levels. One of these models is the unified theory of acceptance and use of technology‐2 (UTAUT2). In this study, the acceptance and usage levels of metaverse technology by students in the context of anatomy education in the metaverse environment have been investigated within the framework of the UTAUT2 model. The study was conducted with students from the Department of Midwifery at the Faculty of Health Sciences during the fall semester of the 2022–2023 academic year. After 6 weeks of anatomy education in the metaverse environment, the student's acceptance and usage levels of metaverse technology were assessed using the UTAUT2 scale. The collected data were analyzed using the partial least squares structural equation modeling method. The research has revealed the technology acceptance and usage levels of students who utilized metaverse technology in anatomy education. According to the obtained results, it has been observed that social influence affects behavioral intention, facilitating conditions influence behavioral intention, and habit variable affects behavioral intention, while habit, in turn, influences usage. Other variables explain behavioral intention with a proportion of 75.30%, whereas other variables explain usage behavior with 54.90%. Upon analyzing the responses to the UTAUT2 scale, it has been concluded that there is the highest level of participation in hedonic motivation. In contrast, the habit variable has the lowest participation level. The findings of this study have enabled the identification of the impacts of metaverse technologies on anatomy and health education. These results will likely contribute to improving the utilization of metaverse technologies in anatomy and health education.
Evaluating knowledge loss over multiple retention intervals can identify deficiencies and inform curricular development
Authors: Neumeier Melanie , Narnaware Yuwaraj (Raj) 
Published: November 2023

AbstractNursing students struggle to retain enough anatomical knowledge to meet their entry to practice competencies, but what knowledge is missing and when this occurs has been previously unexplored. A cohort of 80 nursing students were given multiple choice quizzes to assess their anatomical knowledge on 11 different organ systems during their second, third, and fourth year. Results were analyzed in comparison to their first‐year examination scores to determine knowledge loss. Results showed an overall knowledge loss of 33.5% in the second year, 31.8% in the third year, and 29.6% in the fourth year. There were significant differences in system specific results. Special senses (i.e., audition) had a 20.6% loss in the second year, increased in retention to a 17.3% loss in third year, and then decreased to a 37% loss in fourth year. The vascular system had a 46.1% knowledge loss at the second‐year assessment, declined to 49% knowledge loss in the third year, but improved to 27.6% knowledge loss by the fourth year. A similar change was observed for the musculoskeletal system with second‐year loss at 30.7%, third‐year loss at 40.3%, and fourth‐year loss at 26.6%. These data suggest there are significant differences in the amount of knowledge retained by nursing students depending on the system being tested and the year the test is taken. Identifying the areas and times where anatomical knowledge is lost and gained is valuable for instructors in any program so that specific topics can be targeted at different times with more effective educational strategies.
Transition Metal Triple‐decker Sandwich Complexes Containing Group 13 Elements
Authors: Chatterjee Debipada , Bairagi Subhash , Ghosh Sundargopal 
Published: November 2023

AbstractTransition metal triple‐decker complexes are an interesting class of sandwich complexes that engrossed great attention due to their structures and properties. Over the decades, synthesis of triple‐decker complexes featuring homocyclic, heterocyclic orπ‐conjugated rings as middle decks have been abundantly reported. In this regard, the chemistry of such complexes bearing boron in the middle deck are well explored due to the ability of boron‐containing cycles to readily coordinate bifacially with metal atoms thereby forming triple‐decker complexes. On the other hand, electron counting rules and theoretical calculations have strengthened our knowledge of the structure and bonding in these complexes. Further, these complexes can be used as synthons to generate organometallic polymers having interesting electronic, optical and magnetic properties that can be appropriately tuned to cater to a wide range of applications. In our quest for novel metallaboranes and metallaheteroboranes, we have been successful in isolating various triple‐decker complexes that feature boron in the middle deck. This review explained elaborately the synthesis, structures, and bonding in such complexes reported by us and others.
Multilayer network changes in patients with migraine
Authors: Kim Jinseung , Lee Dong Ah , Lee Ho‐Joon , Park Kang Min 
Published: November 2023

AbstractIntroductionTo investigate changes in the multilayer network in patients with migraine compared to healthy controls.Methods: This study enrolled 82 patients with newly diagnosed migraine without aura and 53 healthy controls. Brain magnetic resonance imaging (MRI) was conducted using a 3‐tesla MRI scanner, including three‐dimensional T1‐weighted and diffusion tensor imaging (DTI). A gray matter layer matrix was created with a morphometric similarity network using T1‐weighted imaging and the FreeSurfer program. A white matter layer matrix was also created with structural connectivity using the DTI studio (DSI) program. A multilayer network analysis was then performed by applying graph theory using the BRAPH program.ResultsSignificant changes were observed in the multilayer network at the global level in patients with migraines compared to the healthy controls. The multilayer modularity (0.177 vs. 0.160, p = .0005) and average multiplex participation (0.934 vs. 0.924, p = .002) were higher in patients with migraines than in the healthy controls. In contrast, the average multilayer clustering coefficient (0.406 vs. 0.461, p = .0005), average overlapping strength (56.061 vs. 61.676, p = .0005), and average weighted multiplex participation (0.847 vs. 0.878, p = .0005) were lower in patients with migraine than in the healthy controls. In addition, several regions showed significant changes in the multilayer network at the nodal level, including multiplex participation, multilayer clustering coefficients, overlapping strengths, and weighted multiplex participation.ConclusionThis study demonstrated significant changes in the multilayer network in patients with migraines compared to healthy controls. This could aid an understanding of the complex brain network in patients with migraine and may be associated with the pathophysiology of migraines. Patients with migraine show multilayer network changes in widespreading brain regions compared to healthy controls, and specific brain areas seem to play a hub role for pathophysiology of the migraine.
Achieving competitive advantage through bricolage: A small business perspective
Authors: Abukari Abdul Jelil , Wenyuan Li , Pomegbe Wisdom Wise Kwabla , Alhassan Alolo Abdul Rasheed Akeji , Epezagne Assamala Ingrid Ruth 
Published: November 2023

AbstractThe entrepreneurial bricolage theory has been connected to a wide range of organizational phenomena, including innovation, firm performance, social entrepreneurship, and opportunity identification. Regrettably, research in this domain is yet to significantly heighten understanding of its connection to competitive advantage, which has been touted as the ultimate goal of any strategic business. This study reverses this trend by looking at the impact of entrepreneurial bricolage on competitive advantage as well as the mediating effect of resource orchestration capability in the relationship. Based on survey data administered to 413 small business enterprises (SBEs), structural equation modeling was used to analyze the results. Results show that entrepreneurial bricolage was significantly related to competitive advantage. Resource orchestration capability partially mediated the relationship between entrepreneurial bricolage and competitive advantage. A novel finding of this study documents resource orchestration capability and entrepreneurial bricolage as antecedents of competitive advantage, which has been missing in prior literature. The study concludes with theoretical and managerial implications and also proffers future research direction.
Renal cell carcinoma in the contralateral kidney with TFE3 gene translocation following chemotherapy for childhood nephroblastoma: A case report and literature review
Authors: Fujisawa Shunsuke , Furukawa Junya , Hara Takuto , Okada Keiske , Chiba Kouji , Nakano Yuzo , Hyodo Toshiki , Nagashima Yoji , Fujisawa Masato 
Published: November 2023

Key Clinical MessageRenal cell carcinoma as a secondary malignant neoplasm is relatively rare; however, the possibility of secondary renal cell carcinoma following chemoradiotherapy for childhood nephroblastoma should be considered.AbstractThe occurrence of secondary renal cell carcinoma (RCC) following chemoradiotherapy for nephroblastoma is relatively rare, especially in microphthalmia transcription factor family translocation renal cell carcinoma. A 13‐year‐old Japanese male was referred to our department for treatment of a right kidney mass. The patient had undergone open left nephrectomy and adjuvant chemotherapy for nephroblastoma, 12 years before. Diagnostic imaging revealed a tumor in the right kidney and a lesion suspected to be metastasis in the left eighth rib. Chromophobe RCC or translocation RCC was suspected from the imaging pattern. TNM classification was cT1aN0M1, and the clinical stage was IV. Partial nephrectomy by robot‐assisted surgery for the right renal tumor and resection of the left eighth rib were performed. Pathologically, the renal tumor was diagnosed as translocation RCC, and the rib lesion demonstrated no evidence of malignancy. We are currently undergoing imaging follow‐up and the patient has been recurrence‐free for 15 months. In this study, we present a rare case of secondary translocation RCC after successful treatment of nephroblastoma.
Controlling C−OAryl Hydrogenolysis vs Aryl Hydrogenation in Lignin Model Depolymerization Using Ni‐, Rh‐ or Ni/Rh‐based Silica Catalysts
Authors: Raachini Rita , Romdhane Ferdaous Ben , Sassoye Capucine , Boutros Maya , Launay Franck 
Published: November 2023

AbstractThis paper focuses on the hydrogenolysis of 2‐phenoxy‐1‐phenylethanone, modelling a pre‐oxidized form of lignin using five catalysts of similar metal content, prepared by impregnation of Ni(II), Rh(III) and both metals onto Aerosil‐380 in the presence of NH3, followed by a reduction step. The materials were characterized in the dried as‐synthesized state and after consecutive reductive and oxidative treatments, showing the great dispersion of the metal (oxide nanoparticles with sizes<2 nm). Working with 1 mol % of the reduced metal (500 °C) per substrate at 180 °C with isopropanol as H‐donor, the most active catalyst, but also the least selective towards phenol, was initially found to be the Ni‐based one. Under similar conditions, the lower capacity of the Rh‐based catalyst to induce H transfer from isopropanol favoured phenol formation but resulted in much slower C−OAr cleavage. Despite a very high dispersion of the two metals in the bimetallic catalysts, no synergy was found, suggesting that Ni would be segregated at the surface. Finally, the best phenol productivity could be reached by reducing the Ni‐based catalyst at 650 °C, which led to a more efficient cleavage of C−OAr bonds. In this way, it was possible to produce 8 times more phenol per hour.
Spectroscopic Techniques to Unravel Mechanistic Details in Light‐Induced Transformations and Photoredox Catalysis
Authors: De Kreijger Simon , Gillard Martin , Elias Benjamin , Troian‐Gautier Ludovic 
Published: November 2023

AbstractThe rapid development of photo(redox) catalysis within the last decades is remarkable to the extent that the utilization of light‐driven processes in organic chemistry has become a credible alternative to current thermal processes. Such advances offer tremendous opportunities of collaborations between scientific realms that can have a drastic impact on the development of the field. In this concept article, a special emphasis is placed on spectroscopic techniques that are used, or could be used, for light‐induced transformations and photoredox catalysis applications. These include spectroelectrochemistry, UV‐VIS, IR and X‐Ray transient absorption spectroscopy, laser pulsed radiolysis (PR), photo‐induced chemically induced dynamic nuclear polarization (Photo‐CIDNP), photoacoustic spectroscopy, time‐resolved Raman spectroscopy (TRRS), time‐resolved Electron Paramagnetic Resonance (TREPR) and time‐resolved dielectric loss spectroscopy (TRDL). The theoretical background behind each technique is briefly introduced followed by selected relevant examples from the literature.