bluuebunny/crossref_metadata_2025_split huggingface dataset:
N‐cadherin: A diagnostic marker to help discriminate primary liver carcinomas from extrahepatic carcinomas
Authors: Gerber Tiemo S. , Ridder Dirk A. , Goeppert Benjamin , Brobeil Alexander , Stenzel Philipp , Zimmer Stefanie , Jäkel Jörg , Metzig Marie Oliver , Schwab Roxana , Martin Steve Z. , Kiss András , Bergmann Frank , Schirmacher Peter , Galle Peter R. , Lang Hauke , Roth Wilfried , Straub Beate K. 
Published: January 2024

AbstractDistinguishing primary liver cancer (PLC), namely hepatocellular carcinoma (HCC) and intrahepatic cholangiocarcinoma (iCCA), from liver metastases is of crucial clinical importance. Histopathology remains the gold standard, but differential diagnosis may be challenging. While absent in most epithelial, the expression of the adherens junction glycoprotein N‐cadherin is commonly restricted to neural and mesenchymal cells, or carcinoma cells that undergo the phenomenon of epithelial‐to‐mesenchymal transition (EMT). However, we recently established N‐ and E‐cadherin expression as hallmarks of normal hepatocytes and cholangiocytes, which are also preserved in HCC and iCCA. Therefore, we hypothesized that E‐ and/or N‐cadherin may distinguish between carcinoma derived from the liver vs carcinoma of other origins. We comprehensively evaluated E‐ and N‐cadherin in 3359 different tumors in a multicenter study using immunohistochemistry and compared our results with previously published 882 cases of PLC, including 570 HCC and 312 iCCA. Most carcinomas showed strong positivity for E‐cadherin. Strong N‐cadherin positivity was present in HCC and iCCA. However, except for clear cell renal cell carcinoma (23.6% of cases) and thyroid cancer (29.2%), N‐cadherin was only in some instances faintly expressed in adenocarcinomas of the gastrointestinal tract (0%–0.5%), lung (7.1%), pancreas (3.9%), gynecological organs (0%–7.4%), breast (2.2%) as well as in urothelial (9.4%) and squamous cell carcinoma (0%–5.6%). As expected, N‐cadherin was detected in neuroendocrine tumors (25%–75%), malignant melanoma (46.2%) and malignant mesothelioma (41%). In conclusion, N‐cadherin is a useful marker for the distinction of PLC vs liver metastases of extrahepatic carcinomas (P < .01).
Curative effect of high‐intensity focused ultrasound in management of different types of ectopic pregnancy: A systematic review
Authors: Ali Mostafa Maged , Abdelsamad Ahmed , Ragab Youssef Ahmed 
Published: January 2024

AbstractEctopic pregnancy (EP) could be defined as any embryo that got implanted in any site rather than the endometrial cavity. Lately, different types of EP were reportedly managed by high‐intensity focused ultrasound (HIFU). We aimed to pool all available data in a systematic review without meta‐analysis and investigate the efficacy and safety tendencies of HIFU among different types of EP. We applied our comprehensive terms in Google Scholar, PubMed, Scopus, Ovid, and PubMed Central databases from their inception until September 23. Retrieved references were gathered using EndNote in which we omitted the duplicates and exported the record for screening. Data regarding characteristics, safety and efficacy outcomes, and baseline information of the enrolled population were extracted. The eligible case reports were assessed using a tool by Murad and colleagues, while the quality of the included cohorts was appraised using the NIH tool. We retrieved 6637 studies, which were scrutinized by titles and abstracts. We scrutinized the full texts of 36 studies and ultimately included a total of 17 studies. All studies were conducted in China, and on different types of ectopic pregnancy including tubal, cervical, intramural, caesarian scar, and corneal ectopic pregnancy. The mean age of enrolled patients was 33.03 years, and we pooled a total sample of 853 patients. The follow‐up period varied widely among the included studies, ranging from 1.3 months to up to 69 months. Normal menstruation recurred after a mean of 35 days, as reported by nine studies. Most of the included studies reported normal β‐HCG after around 30–40 days. Twelve studies with 757 patients reported a cumulative incidence of 179 cases of abdominal pain after HIFU. Neither of the enrolled patients reportedly complained of skin burn after HIFU. We suggested managing EP patients with HIFU, especially when seeking further conceiving. High‐quality randomized controlled trials are required to draw a stronger level of evidence.
The contribution of digital business strategy in enhancing collaborative innovation capability: The moderating role of organizational culture—A case study of six pharmaceutical companies in Jordan
Authors: Al‐ma'aitah Mohammad Atwah 
Published: January 2024

AbstractWith innovation becoming more collaborative, the influence of digital business strategy (DBS) on interfirm cooperation has grown. This study investigates how DBS can enhance collaboration innovation capabilities across pharmaceutical companies in developing countries. Further, it investigates organizational culture as a moderating variable in the relationship between DBS and collaborative innovation capability (CIC). A total of 205 questionnaire responses were gathered on six Jordanian pharmaceutical corporations. The findings showed that each DBS element (development, objectives, resources, management capabilities, and digital leadership) positively affected CIC, and that organizational culture positively moderated the relationship between DBS and CIC. These results provide valuable insights for managers seeking to improve collaborative capability by leveraging digital business strategies and organizational culture.
Bedouin mothers' sense of authentic inner compass as a parenting resource: Relations with autonomy‐supportive parenting and adolescents' well‐being
Authors: Cohen Rinat , Assor Avi , Al‐Atawna ‐ Hoashle Huwaida , Gueta Bat‐El , Steffgen Teresa , Otterpohl Nantje , Schwinger Malte , Kanat‐Maymon Yaniv 
Published: January 2024

AbstractIntroductionSense of authentic inner compass (AIC) is the feeling that one knows what is important to oneself because one has values, aspirations, and goals with which one deeply identifies. Past research demonstrated the benefits of AIC, but there is no published research on parental dispositions promoting youth AIC. To increase knowledge of this issue, we examined whether mothers' sense of AIC is associated with a corresponding sense of AIC in their children, and explored autonomy‐supportive child‐rearing practices that may serve as pathways linking mothers' AIC with adolescents' AIC and subsequent well‐being. We examined a Bedouin Israeli sample because it represents a fairly patriarchal, autonomy‐eschewing, context, where the benefits of mothers' authenticity and autonomy‐support are not obvious.MethodOne hundred and thirty‐six mothers (Mean age = 44.33, SD = 5.22) and their children (Mean age = 13.79, SD = 0.45; 60% females) participated in a study conducted in June 2019.ResultsSEM analyses supported a model where mothers' sense of firm AIC was linked with adolescents' sense of firm AIC via adolescents' experience of their mothers as using the practices of inherent value demonstration and fostering inner valuing. Adolescent reported AIC in turn was associated with adolescents reported vitality and low levels of depressive symptoms. Mothers' AIC was associated with minimal use of conditional regard, which was negatively associated with depressive symptoms.ConclusionsResults suggest that mothers' AIC may be an important parenting resource, enabling mothers to convincingly demonstrate their values, as well as foster children's attunement to their authentic preferences, even in patriarchal‐hierarchical contexts.
Disease and development—The predicted mortality instrument revisited
Authors: Kreitmeir David , Überfuhr Thomas 
Published: January 2024

AbstractThis paper revisits Acemoglu‐Johnson the predicted mortality instrument. Drawing on a unique historical data set of disease‐specific mortality rates, we reconstruct several versions of the instrument that differ in terms of data usage and instrument relevance. Our findings confirm its predictive power on life expectancy. The replication analysis reveals a significant positive second‐stage effect of life expectancy on population and total birth rates and a negative effect on GDP per capita for a subset of the revised instruments. Overall, data coverage and empirical tests suggest the superiority of our country‐level instrument.
Low baseline ribosome‐related gene expression and resistance training‐induced declines in ribosome‐related gene expression are associated with skeletal muscle hypertrophy in young men and women
Authors: Brown Alex , Parise Gianni , Thomas Aaron C. Q. , Ng Sean Y. , McGlory Chris , Phillips Stuart M. , Kumbhare Dinesh , Joanisse Sophie 
Published: January 2024

AbstractRibosomes are essential cellular machinery for protein synthesis. It is hypothesised that ribosome content supports muscle growth and that individuals with more ribosomes have greater increases in muscle size following resistance training (RT). Aerobic conditioning (AC) also elicits distinct physiological adaptations; however, no measures of ribosome content following AC have been conducted. We used ribosome‐related gene expression as a proxy measure for ribosome content and hypothesised that AC and RT would increase ribosome‐related gene expression. Fourteen young men and women performed 6 weeks of single‐legged AC followed by 10 weeks of double‐legged RT. Muscle biopsies were taken following AC and following RT in the aerobically conditioned (AC+RT) and unconditioned (RT) legs. No differences in regulatory genes (Ubf, Cyclin D1, Tif‐1a and Polr‐1b) involved in ribosomal biogenesis or ribosomal RNA (45S, 5.8S, 18S and 28S rRNAs) expression were observed following AC and RT, except for c‐Myc (RT > AC+RT) and 5S rRNA (RT < AC+RT at pre‐RT) with 18S external transcribed spacer and 5.8S internal transcribed spacer expression decreasing from pre‐RT to post‐RT in the RT leg only. When divided for change in leg‐lean soft tissue mass (ΔLLSTM) following RT, legs with the greatest ΔLLSTM had lower expression in 11/13 measured ribosome‐related genes before RT and decreased expression in 9/13 genes following RT. These results indicate that AC and RT did not increase ribosome‐related gene expression. Contrary to previous research, the greatest increase in muscle mass was associated with lower changes in ribosome‐related gene expression over the course of the 10‐week training programme. This may point to the importance of translational efficiency rather than translational capacity (i.e. ribosome content) in mediating long‐term exercise‐induced adaptations in skeletal muscle.
Contactless conductivity detector as a tool for improving universality and sensitivity of capillary electrophoresis‐frontal analysis: Proof of concept
Authors: Bržezická Taťána , Mlčochová Hana , Glatz Zdeněk , Kohútová Lenka 
Published: January 2024

Drug binding to plasma proteins influences processes such as liberation, adsorption, disposition, metabolism, and elimination of drugs, which are thus one of the key steps of a new drug development. As a result, the characterization of drug–protein interactions is an essential part of these time‐ and money‐consuming processes. It is important to determine not only the binding strength and the stoichiometry of interaction, but also the binding site of a drug on a protein molecule, because two drugs with the same binding site can mutually affect free drug concentration. Capillary electrophoresis‐frontal analysis with mobility shift affinity capillary electrophoresis is one of the most used affinity capillary electrophoresis methods for the characterization of these interactions. In this study, a well‐known sensitivity problem of most capillary electrophoresis‐frontal analyses using ultraviolet detection is solved by its combination with contactless conductivity detection, which provided sixfold lower limits of quantitation and detection. Binding parameters of the human serum albumin‐salicylic acid model affinity pair were evaluated by this newly developed approach and by the classical approach with ultraviolet detection primarily used for their mutual comparison. The results of both approaches agreed well and are also in agreement with literature data obtained using different techniques.
Analysis of 14 β‐agonists in pork using an automated wooden tip‐based solid‐phase microextraction device and ultra‐high‐performance liquid chromatography–tandem mass spectrometry
Authors: Li Kai , Gong Xiaoming , Jin Liming , Liu Mengxiao , Hua Mengmeng 
Published: January 2024

This study introduces a cost‐effective, automated ultra‐high‐performance liquid chromatography–tandem mass spectrometry method for the detection of 14 β‐agonists in pork using a novel solid‐phase microextraction probe composed of polyacrylonitrile and molecularly imprinted polymer. Integrated into an automated extraction device, the probe optimizes extraction prior to analysis while reducing expenses and time compared to traditional solid‐phase extraction procedures. The method validation followed the Chinese National Standard (GB/T 27404‐2008) and examined limits of detection, limits of quantification, matrix effects, linearity, intraday, and interday precision. Average recovery rates ranged from 71.6% to 82.2%, with relative standard deviations less than 15%. Limits of detection and limits of quantification ranged from 0.09 to 0.39 and 0.27 to 0.99 μg/kg, respectively. The new method identified positive samples more accurately than the current National Standard GB/T 31658.22‐2022 and demonstrated its potential for routine assessment and regulatory compliance in the detection of β‐agonists in pork.
Pepsin Inhibitors Prevent Inflammation and Loss of Laryngeal Barrier Function in Mice with Gastroesophageal Reflux
Authors: Sales Thiago M.A.L. , Sidou Flavio M.N.O. , da Costa Filho Humberto B. , de Melo Nogueira Kerolayne , Dias Júnior Genilson J. , de Sousa Lima Marcos A. , da Silva Lara M.G. , Nicolau Lucas A.D. , Soares Pedro M.G. , Nobre e Souza Miguel Â. , Sifrim Daniel , de Souza Marcellus H.L.P. 
Published: January 2024

ObjectiveThis study aimed to evaluate the role of pepsin inhibitors in the inflammatory response and their effects on laryngeal mucosal integrity during gastroesophageal reflux (GERD) under in vivo conditions.MethodsA surgical model of GERD was used, in which mice were treated with pepstatin (0.3 mg/kg) or darunavir (8.6 mg/kg) for 3 days. On the third day after the experimental protocol, the laryngeal samples were collected to assess the severity of inflammation (wet weight and myeloperoxidase activity) and mucosal integrity (transepithelial electrical resistance and paracellular epithelial permeability to fluorescein).ResultsThe surgical GERD model was reproduced. It showed features of inflammation and loss of barrier function in the laryngeal mucosa. Pepstatin and darunavir administration suppressed laryngeal inflammation and preserved laryngeal mucosal integrity.ConclusionPepsin inhibition by the administration of pepstatin and darunavir improved inflammation and protected the laryngeal mucosa in a mouse experimental model of GERD.Level of EvidenceNA Laryngoscope, 134:3080–3085, 2024
Frequency‐to‐Place Mismatch Impacts Cochlear Implant Quality of Life, But Not Speech Recognition
Authors: Sturm Joshua J. , Ma Cheng , McRackan Theodore R. , Schvartz‐Leyzac Kara C. 
Published: January 2024

ObjectiveTo retrospectively compare frequency‐place mismatch among adult cochlear implant (CI) recipients with lateral wall (LW) and perimodiolar/Mid Scala (PM/MS) arrays, and to quantify the impact of these factors on early post‐activation (3 months) speech recognition abilities and CI‐specific quality of life.MethodsOne hundred and twenty‐six adult participants were separated into two groups: (1) 83 participants who underwent CI with a PM/MS array and 43 patients who underwent CI with a LW array. All participants completed the Cochlear Implant Quality of Life Profile (CIQOL‐35 Profile) instrument. Angular insertion depth and semitone mismatch, which contribute to frequency‐place mismatch, were assessed using post‐operative CT scans. Word and speech recognition in quiet were determined using the Consonant‐Nucleus‐Consonant (CNC) and the AzBio tests, respectively (n = 82 patients).ResultsLW arrays were more deeply inserted and exhibited less semitone mismatch compared to PM/MS arrays. No significant relationship was found between semitone mismatch and early post‐operative speech perception scores for either PM/MS or LW arrays. However, greater degrees of semitone mismatch were associated with lower CIQOL‐35 profile scores for PM/MS arrays.Conclusions and RelevanceThe results of this study indicate that both the degree of frequency‐place mismatch, and its impact on CI‐specific quality of life, vary by CI array design.Level of Evidence4 Laryngoscope, 134:2898–2905, 2024
Head and neck ultrasound training improves the diagnostic performance of otolaryngology residents
Authors: Warm Jens Jessen , Melchiors Jacob , Kristensen Tina Toft , Aabenhus Kristine , Charabi Birgitte Wittenborg , Eberhard Kristine , Konge Lars , von Buchwald Christian , Todsen Tobias 
Published: January 2024

AbstractObjectiveSurgeon‐performed head and neck ultrasound (US) is increasingly used among otolaryngologists in office‐based and surgical settings. However, it is unknown how formal US training affects otolaryngology residents' diagnostic workup of patients with cervical pathology. This study examined how a formal US course for residents affected their outpatient clinic US performance and diagnostic accuracy.MethodsWe conducted a randomized cross‐over trial, where 13 otolaryngology residents participated in a 6‐h formal US course. Participants were randomized to perform head and neck US on four patient cases before and after completing the course. Eight patients with and without neck pathology were invited to participate as test cases. The ultrasound examinations were video recorded and anonymized before two consultants rated the US performance using the Objective Structured Assessment of Ultrasound Skills (OSAUS) scale. Otolaryngology residents wrote an ultrasound report with a diagnosis based on their US examination, which was used to calculate the specificity and sensitivity.ResultsWe found a statistically significant difference in the OSAUS score before compared to after the hands‐on training (p = .035). The diagnostic accuracy also increased from 62% before the course to 75% after the course (p = .02). Specificity increased from 54% prior to the course to 62% following the course, and sensitivity increased from 64% prior to the course to 79% following the course. The intraclass correlation coefficient with “absolute agreement” was 0.63.ConclusionThis study demonstrates that short, formal ultrasound training can improve otolaryngology residents' ultrasound skills and diagnostic accuracy in an outpatient clinic setting.Lay summaryThis study looks at the change of otolaryngology residents' diagnostic workup of patients after they take a formal ultrasound course and shows that they get better at using ultrasound and make more accurate diagnoses if they take a formal course.Level of EvidenceLevel 2.
Another Year of Milestones and Advancements Ahead
Authors: Atwood Stephen P. 
Published: January 2024

AbstractInformation Display (ID) has an exciting year ahead. We will celebrate our 60th anniversary—the first issue of ID was published in October 1964. It was inevitable, after the founders agreed to “encourage the scientific, literary and educational advancement of information display and its allied arts,” that they set out to create chapters around the world, hold conferences to educate people, and provide platforms to publish members’ groundbreaking work.
Male guarding behavior and brood predators of invasive Bluegill in a Japanese lake
Authors: Peterson Miles I. , Kitano Satoshi 
Published: January 2024

Abstract

Objective
The Bluegill Lepomis macrochirus, which utilizes colony spawning, has been introduced globally, and in Japan it is considered one of the worst invasive species. However, a detailed examination of the factors driving male guarding behavior and brood predation in the invaded habitat is lacking. The removal of guarding males, a common management technique in Japan, is thought to be effective in controlling Bluegill. However, the colony spawning strategy may influence the effectiveness of selective male removal through brood protection from neighbor males.

Methods
Bluegill spawning was studied in Lake Nojiri, Nagano, Japan, using underwater video recording and experimental removal of guarding males.

Result
Bluegill were found spawning in shallow habitat during June–July, and nests were constructed in loosely aggregated colonies, with many solitary nests. Males utilized a variety of guarding behaviors, such as rim circling and predator chases, as well as paternal investment behaviors, such as tail fanning. Males that preyed upon their own eggs defended their nests less aggressively and invested less time in nourishing behaviors. Removal of guarding males revealed that brood predators were primarily conspecific Bluegill, but other fishes, such as invasive Smallmouth Bass Micropterus dolomieu and Largemouth Bass M. nigricans as well as native Japanese Dace Pseudaspius hakonensis, preyed on broods.

Conclusion
In concurrence with the colony spawning theory, nests that were located closer to other nests with active guarding males experienced decreased brood predation and increased predator arrival time after male removal. In addition, nests where males had been guarding more aggressively prior to removal experienced reduced brood predation after male removal. These results provide insights into the factors driving male guarding behavior and brood predation of colony-spawning Bluegill in an invasive habitat and indicate that the removal of guarding males—a common management strategy in Japan—may have reduced effectiveness due to colony spawning.
Nutrition challenges following total pancreatectomy with islet autotransplantation
Authors: Hasse Jeanette M. , Meng Shumei , Silpe Stephanie , Naziruddin Bashoo 
Published: January 2024

AbstractTotal pancreatectomy with islet autotransplantation (TPIAT) is a surgical treatment option for patients with chronic pancreatitis who have not responded to other therapies. TP offers pain relief whereas IAT preserves beta cell mass to reduce endocrine insufficiency. During the surgical procedure, the entire pancreas is removed. Islet cells from the pancreas are then isolated, purified, and infused into the liver via the portal vein. Successful TPIAT relieves pain for a majority of patients but is not without obstacles, specifically gastrointestinal, exocrine, and endocrine challenges. The postoperative phase can be complicated by gastrointestinal symptoms causing patients to have difficulty regaining adequate oral intake. Enteral nutrition is frequently provided as a bridge to oral diet. Patients undergoing TPIAT must be monitored for macronutrient and micronutrient deficiencies following the procedure. Exocrine insufficiency must be treated lifelong with pancreatic enzyme replacement therapy. Endocrine function must be monitored and exogenous insulin provided in the postoperative phase; however, a majority of patients undergoing TPIAT require little or no long‐term insulin. Although TPIAT can be a successful option for patients with chronic pancreatitis, nutrition‐related concerns must be addressed for optimal recovery.