bluuebunny/crossref_metadata_2025_split huggingface dataset:
The macrocycle inhibitor landscape of SLC‐transporter
Authors: Granulo Nejra , Sosnin Sergey , Digles Daniela , Ecker Gerhard F. 
Published: January 2024

AbstractIn the past years the interest in Solute Carrier Transporters (SLC) has increased due to their potential as drug targets. At the same time, macrocycles demonstrated promising activities as therapeutic agents. However, the overall macrocycle/SLC‐transporter interaction landscape has not been fully revealed yet. In this study, we present a statistical analysis of macrocycles with measured activity against SLC‐transporter. Using a data mining pipeline based on KNIME retrieved in total 825 bioactivity data points of macrocycles interacting with SLC‐transporter. For further analysis of the SLC inhibitor profiles we developed an interactive KNIME workflow as well as an interactive map of the chemical space coverage utilizing parametric t‐SNE models. The parametric t‐SNE models provide a good discrimination ability among several corresponding SLC subfamilies’ targets. The KNIME workflow, the dataset, and the visualization tool are freely available to the community.
Introductory editorial: Lifelong LUTS, a matter of transition?
Authors: Everaert Karel , Bou Kheir George , Vande Walle Johan , Verbakel Irina , Hervé François ,   NOPIA Research Group
Published: January 2024

AbstractIntroductionThe EPIC study has highlighted the prominence of nocturia as a crucial symptom of overactive bladder (OAB), intertwining OAB and nocturia with bladder, kidney, and brain functions.MethodsExpert opinion, review.ResultsTo truly comprehend lower urinary tract symptoms (LUTS), we must delve into the interactions among these three systems, alongside their circadian rhythms.ConclusionThe perception of LUTS is a result of the intricate interplay between bladder, brain, and kidney function, which may evolve across a lifetime due to the (dys)functionality of these organs.
Food and alcohol disturbance among people who have undergone bariatric surgery
Authors: White Gretchen E. , Steers Mai‐Ly N. , Bernardi Karla , Kalarchian Melissa A. 
Published: January 2024

AbstractThere have been numerous investigations of aberrant eating and substance abuse among patients who have undergone bariatric surgery, which affects the metabolism and the pharmacokinetics of alcohol. However, there is a dearth of literature considering the complex interplay between changes in post‐surgery food and alcohol consumption. Furthermore, despite the increasing recognition of issues surrounding replacing food consumption with alcohol consumption (Food and Alcohol Disturbance [FAD]), most emerging research has focused on young adult populations. This perspective reviews and synthesizes the small but growing body of research on the interplay between food and alcohol consumption, particularly FAD, and considers its application to bariatric surgery in general. There are unique considerations for patients who have undergone bariatric surgery. Patients experience altered gastric anatomy, which affects food and alcohol metabolism, and are advised to abstain from drinking alcohol after surgery. After reviewing the available literature, this perspective highlights future directions for research and practice in bariatric surgery.
Tracheostomy and long‐term invasive ventilation decision‐making in children: A scoping review
Authors: Mack Cheryl , Mailo Janette , Ofosu Daniel , Hinai Alreem A. , Keto‐Lambert Diana , Soril Lesley J. J. , van Manen Michael , Castro‐Codesal Maria 
Published: January 2024

AbstractAn increasing number of children are surviving critical illnesses requiring tracheostomy/long‐term ventilation (LTV). This scoping review seeks to collate the available evidence on decision‐making for tracheostomy/LTV in children. Systematic searches of electronic databases and websites were conducted for articles and reports. Inclusion criteria included: (1) children 0–18 years old; (2) described use of tracheostomy or tracheostomy/LTV; and (3) information on recommendations for tracheostomy decision‐making or decision‐making experiences of family‐caregivers or health care providers. Articles not written in English were excluded. Of the 4463 records identified through database search and other methods, a total of 84 articles, 2 dissertations, 1 book chapter, 3 consensus statement/society guidelines, and 8 pieces of grey literature were included. Main thematic domains identified were: (1) legal and moral standards for decision‐making; (2) decision‐making models, roles of decision‐makers, and decisional aids towards a shared decision‐making model; (3) experiences and perspectives of decision‐makers; (4) health system and society considerations; and (5) conflict resolution and legal considerations. A high degree of uncertainty and complexity is involved in tracheostomy/LTV decision‐making. There is a need for a standardized decision‐support process that is consistent with a child's best interests and shared decision‐making. Strategies for optimizing communication and mechanism for managing disputes are needed.
Seroprevalence and biochemical parameters among patients with Chikungunya in Adamaoua region, Cameroon: A cross‐sectional study
Authors: Djamko Toko Lise Paule , Galani Tietcheu Borris Rosnay , Tembar Ilyassa Dieudonné , Chuisseu Djamen Pascal Dieudonne , Njintang Yanou Nicolas 
Published: January 2024

AbstractBackgroundChikungunya virus (CHIKV) infection is a vector‐borne febrile illness endemic to Africa. In Cameroon, few studies have documented human exposure to CHIKV, especially in the Adamaoua region. This study aimed to assess the CHIKV seroprevalence in Ngaoundere city and analyze likely association with social, clinical, and biochemical determinants.MethodsA cross‐sectional study was conducted at the Ngaoundere Regional Hospital from July to October 2022. The sociodemographic and clinical informations of participants were recorded using a standardized questionnaire. Then, blood tests were performed to determine the CHIKV status, the transaminase, and lipid profiles.ResultsOf the 200 persons surveyed, 21.5% (43) were positive for anti‐CHIKV IgM antibodies. Age, sex, occupation, marital status, level of study, and place of residence were not significantly associated with CHIKV. However, fever (RR = 4.19; 42.86%;p = 0.0124), headaches (RR = 4.89; 50%;p = 0.0007), digestive disorders (RR = 6.52; 66.67%;p = 0.0001), and the presence of at least two clinical symptoms (RR = 2.55; 26.09%;p = 0.009) were significantly correlated with the presence of CHIKV compared with the absence of clinical symptoms (RR = 1, 10.23%). Similarly, cases of CHIKV were significantly more important in subjects with high aspartate aminotransferase (AST) than in those with normal AST (RR = 2.45; 37.50% vs. 15.28%;p = 0.0006). No significant association was found between alanine‐aminotransferase and lipid profile markers.ConclusionNgaoundere populations seem to be commonly infected with CHIKV, increasing the incidence of febrile symptoms and transaminase elevation. Clinical and metabolic monitoring is required.
Hydrothermal Synthesis and Photocatalytic Activity of NiTiO3 for the Degradation of Malachite Green under Visible Light Irradiation
Authors: El Yakine Layachi Nour , Bendjeffal Hacene , Drici Abdelaziz , Djebli Abdelkrim 
Published: January 2024

AbstractThis study was dedicated to the development of an efficient, low‐cost, and environmentally friendly perovskite system for the elimination of recalcitrant dye from aqueous media by exploiting the photocatalytic performance of
. The material was successfully obtained by hydrothermal synthesis in a Teflon batch‐type reactor system and then characterized by X‐ray diffraction (XRD), scanning electron microscopy (SEM), ultraviolet‐visible spectroscopy (UV‐Vis), and Brunauer‐Emmett‐Teller analysis. The experimental analysis shows that after calcination at 800 °C, the
phase is well crystallized. The as‐synthesized
shows a band gap energy of
and a surface area of 82.18 m2 −1. The degradation experiments were optimized using the One‐Factor‐at‐a‐Time strategy under the effect of four (4) operating factors, including catalyst dose (0.1–1) g L−1, medium pH (1–11), hydrogen peroxide concentration (0.025–0.250)
, and
initial dose (5–50)
. The attained results illustrate that malachite green elimination increased with the rise of the H2O2 concentration and the catalyst dose. The optimum conditions determined at room temperature were
=
=0.5 g L−1,
=0.250
, and pH 3 with a total removal efficiency (~100 %) achieved after 20 min of reaction. The results showed that the
material is an outstanding visible‐light‐driven catalyst material for the photodegradation of MG under visible‐light irradiation.
Pyreno[4,5‐d]imidazole‐triazatruxene Dyads for OLED Applications
Authors: Khamlue Rattapon , Loythaworn Thidarat , Namuangruk Supawadee , Promarak Vinich , Rashatasakhon Paitoon 
Published: January 2024

AbstractTwo new structural isomers of pyreno[4,5‐d]imidazole‐triazatruxene (C‐Pyl‐TAT and N‐Pyl‐TAT) were successfully synthesized via microwave‐assisted Suzuki cross‐coupling reaction. The target compounds were characterized by 1H‐NMR, 13C‐NMR and MALDI‐TOF mass spectroscopy. These compounds emitted blue fluorescence signals with maxima wavelengths around 434 and 436 nm in toluene solution. They exhibited good film‐forming properties and thermal stabilities with glass‐transition temperature (Tg) and decomposition temperature (T5d) above 128 °C and 390 °C, respectively. The solution‐processed Alq3‐based devices with the structure of ITO/PEDOT:PSS/HTL/Alq3/LiF:Al were fabricated to evaluate the hole‐transporting properties of these compounds. The performance of the device with C‐Pyl‐TAT as a hole‐transporting layer (HTL) showed a low turn‐on voltage of 2.8 V, a high external quantum efficiency of 1.07 %, and a maximum luminance of 19,770 cd m−2. Moreover, the use of spin‐casted films of 1,3‐bis(N‐carbazolyl)benzene doped with C‐Pyl‐TAT or N‐Pyl‐TAT as blue‐emitting materials in OLED devices were also demonstrated.
Recent Advances in Stimuli‐Responsive Luminescent Supramolecular Lanthanide‐Based Metallogels
Authors: Roy Bilash Chandra , Kundu Animesh , Biswas Pranjit , Roy Saheli , Singha Mahapatra Tufan 
Published: January 2024

AbstractThe use of lanthanide‐based metallogels presents a promising approach for the engineering of stimuli‐responsive gel materials. Stimuli‐responsive luminescent materials based on lanthanides have promising applications in bio‐applications and optical encoding. Synthetic supramolecular metallogels typically become kinetically trapped and usually do not exhibit time‐variable changes in their material properties. However, such supramolecular metallogels can switch between gel to sol when subjected to different external physical and chemical stimuli. This is because weak noncovalent interactions hold together the gel structure and are also influenced by the coordination dynamics of the metal‐ligand bond. This review summarizes recent research progress on stimuli‐responsive supramolecular lanthanide‐based luminescent metallogels. Chemical, physical, and multiple stimuli‐responsiveness of the metallogels are discussed elaborately based on the external stimulus sources. Finally, the latest challenges and opportunities for developing novel metallogels that respond to stimuli are discussed.
Lipid Nanocarrier‐Based mRNA Therapy: Challenges and Promise for Clinical Transformation
Authors: Li Wenchao , Wang Chen , Zhang Yifei , Lu Yuan 
Published: January 2024

AbstractDue to the outbreak of novel coronavirus pneumonia, messenger RNA (mRNA) technology has attracted heated attention. A specific, safe, and efficient mRNA delivery system is needed. Lipid nanocarriers have become attractive carriers for mRNA delivery due to their high delivery efficiency, few side effects, and easy modification to change their structures and functions. To achieve the desired biological effect, lipid nanocarriers must reach the designated location for effective drug delivery. Therefore, the effects of the composition of lipid nanocarriers on their key properties are briefly reviewed. In addition, the progress of smart drug delivery by changing the composition of lipid nanocarriers is summarized, and the importance of component design and structure is emphasized. Subsequently, this review summarizes the latest progress in lipid nanocarrier‐based mRNA technology and provides corresponding strategies for its current challenges, putting forward valuable information for the future design of lipid nanocarriers and mRNA.
Boosting Electrochemical CO2 Reduction on Copper‐Based Metal‐Organic Frameworks via Valence and Coordination Environment Modulation
Authors: Deng Jun , Qiu Limei , Xin Mudi , He Wenhui , Zhao Wenhui , Dong Juncai , Xu Guangtong 
Published: January 2024

AbstractCu‐based metal‐organic frameworks (MOFs) have attracted much attention for electrocatalytic CO2 reduction to high value‐added chemicals, but they still suffer from low selectivity and instability. Here, an associative design strategy for the valence and coordination environment of the metal node in Cu‐based MOFs is employed to regulate the CO2 electroreduction to ethylene. A novel “reduction‐cleavage‐recrystallization” method is developed to modulate the Cu(II)‐Trimesic acid (BTC) framework to form a Cu(I)‐BTC structure enriched with free carboxyl groups in the secondary coordination environment (SCE). In contrast to Cu(II)‐BTC, the Cu(I)‐BTC shows higher catalytic activity and better ethylene selectivity (≈2.2‐fold) for CO2 electroreduction, which is further enhanced by increasing the content of free carboxyl groups, resulting in ethylene Faraday efficiency of up to 57% and the durability of the catalyst could last for 38 h without performance decline. It indicates that the synergistic effect between Cu(I)‐O coordinated structure and free carboxyl groups considerably enhances the dimerization of *CO intermediates and hinders the hydrogenation of *CO intermediates in these competitive pathways. This work unravels the strong dependence of CO2 electroreduction on the Cu valence state and coordination environment in MOFs and provides a platform for designing highly selective electrocatalytic CO2 reduction catalysts.
Single Atom Ru Doped Ni2P/Fe3P Heterostructure for Boosting Hydrogen Evolution for Water Splitting
Authors: Li Xiuhui , Niu ZeYuan , Niu Mang , Wang JiaXin , Cao Dapeng , Zeng Xiaofei 
Published: January 2024

AbstractModulating the chemical composition and structure has been considered as one of the most promising strategies for developing high‐efficient water splitting catalysts. Here, a single‐atom Ru doped Ni2P/Fe3P catalyst is synthesized by introducing the dispersed Ru atoms to adjust Ni2P/Fe3P heterostructure. Single atom Ru provides effective hydrogen evolution reaction (HER) active sites for boosting catalytic activities. The catalyst with only 0.2 wt.% content of Ru exhibits an overpotential of 19.3 mV at 10 mA cm−2, which is obviously lower than 146.1 mV of Ni2P/Fe3P. Notably, an alkaline overall water electrolyzer based on Ru‐Ni2P/Fe3P catalysts achieves a cell voltage of 1.47 V and operates over 600 h at 10 mA cm−2, which is superior to that of benchmark RuO2//Pt/C (1.61 V). The theoretical calculations further confirm that Ru single atom doping can effectively optimize the hydrogen/water adsorption free energy of the active site and therefore improve the HER activity of heterostructure. This work provides a valuable reference to design high‐activity and durability catalyst for water splitting through the double modulation of interface‐effect and atomic doping.
Decolonizing English‐Medium Instruction in the Global South
Authors: Sah Pramod K. , Fang Fan 
Published: January 2024

AbstractMany societies in the Global South have adopted English‐medium instruction (EMI) policies, but often ignoring—whether by design or involuntarily—the damages caused by the colonial legacy inherent in EMI. This neglect of the repercussions has also been inadequately addressed in the current EMI scholarship. Additionally, overlooking the coloniality and lasting effects of this neglect within the EMI scholarship could inadvertently perpetuate colonial ideologies, policies, and discourses. Therefore, this forum article makes an urgent call for a need to employ a decolonial lens in EMI research and practices in the Global South. This approach seeks to disrupt the entwined relationship between coloniality and EMI by encouraging various stakeholders to critically examine and challenge the unequal power dynamics present in language ideologies, policies, and practices and social groups across diverse educational settings. We argue that a decolonial endeavor obliges us to be mindful of how EMI programs and research may inadvertently favor economic, political, and social advantages for privileged groups and nation‐states.
Canine immune‐mediated polyarthritis: A review of 84 cases in the UK between 2011 and 2021
Authors: Perez Judith Cruzado , Travail Victoria , Lamb Valerie , Kelly Darren 
Published: January 2024

AbstractBackgroundImmune‐mediated polyarthritis (IMPA) is a well‐recognised disease in dogs, but studies evaluating the response rates, relapse rates and long‐term outcomes are scarce.ObjectivesTo provide an updated description of the signalment, clinical signs, clinicopathological findings, distribution between subgroups, rates of response and relapse and long‐term outcome of 84 dogs diagnosed with IMPA at a single referral hospital.MethodsDogs diagnosed with IMPA between January 2011 and December 2021 were identified. Dogs with neutrophilic inflammation in ≥2 joints were included. Cases with <1 month of follow‐up, or those missing pertinent data, were excluded.ResultsA total of 84 cases were included. An initial response was achieved in 77/84 (92%) cases. Of the cases that initially responded, 37/77 (48%) suffered at least one relapse and 18/77 (23%) suffered multiple relapses. Indefinite treatment was recommended in 17/84 (20%) cases. Of the 70 dogs for which at least 12 months of follow‐up data were available, 12/70 (17%) were euthanised due to IMPA or for unknown reasons.ConclusionIMPA carries a fair prognosis, but relapses occur in many cases and euthanasia due to relapsing or refractory disease is not uncommon.
A Versatile Comproportionation Route to Construct Mono‐Imido Trichlorido Complexes of Molybdenum(V) and Tungsten(V)
Authors: Leitner Daniel , Wurst Klaus , Hohloch Stephan 
Published: January 2024

AbstractWe report the facile and high‐yielding multi‐gram synthesis of pentavalent heavy group VI mono‐imido complexes with the general formula M(NR)Cl3Ln (M=Mo, W, R=Aryl or Alkyl, L=DME n=1 or Py n=2) following a comproportionative imido group transfer procedure starting from the corresponding bis‐imido complexes and MCl4. The procedure works well for both aryl and alkyl imido ligands, in the case of molybdenum but only for alkyl imidos in the case of tungsten. Overall, five mono‐imido complexes have been structurally characterized and purity is established by elemental analysis and EPR spectroscopy.
Introduction: The Expanding Imagination of Mainstream French Films and Television Series
Authors: Harrod Mary , Moine Raphaëlle 
Published: January 2024

AbstractThis chapter surveys the historical background to and recent landscape of Frenchness as articulated in mainstream postnational film and television. This involves a dialogue that aims to build on and update existing scholarship on trans/postnational media industries, as a foundation for deciding which perspectives are most fitting when turning subsequently to significant trends in texts themselves. An overview of the rationale for the book’s chapter selection, accompanied and followed by summaries and extrapolations of the foci and implications of each, reflects the twin objectives of capturing a representative variety of empirical developments in media production and testing apt paradigms for their analysis. The chapter points to initial conclusions about key emergent features of both on-screen postnational Frenchness and comparable identities linked to contemporary screen cultures in general.
Camille Cottin: A Comic Reappropriation of French Femininity in a Globalised, Postfeminist Culture
Authors: Kaftal Anne 
Published: January 2024

AbstractThis chapter explores how Camille Cottin’s star persona crystallises the circulation of French femininity between contemporary French culture and a globalised postfeminist culture, and in the particular field of comedy, which is strongly determined by national contexts. The author specifically aims to understand how the global postfeminist figure of the Parisienne interacts, within Cottin’s star image, with French comic traditions and what this interaction entails in terms of gender representation.
Sign Language, Multilingualism and the Postnational Popular Screen: From La Famille Bélier and Marie Heurtin to La Révolution
Authors: King Gemma 
Published: January 2024

AbstractSince the mid-2000s, the representation of multiple languages on French screens has increased significantly. However, an understudied element of this cinema is the growing corpus of films and series in French Sign Language (LSF). This chapter explores the evolution of multilingual French cinema in the twenty-first century. Placing Indigenous multilingualism within a broader translingual context, it focuses on the 2014 films La Famille Bélier/The Bélier Family (Eric Lartigau) and Marie Heurtin (Jean-Pierre Améris) and the 2020 series La Révolution/The Revolution (François Lardenois and Aurélien Molas) to examine the relationship between French Sign Language and French through a postnational lens. The chapter explores how these LSF texts challenge received norms of Frenchness, their connection to the French language and what ‘national language’ means for a nation that was always already multilingual.
Alexandre Aja: A Postnational Genre Auteur?
Authors: Goodall Reece 
Published: January 2024

AbstractThis chapter examines Alexandre Aja’s output across borders and explores whether questions of nationality are as important to understanding his filmography as is the issue of genre. It argues that by openly embracing a globally popular genre, working with culturally important horror figures and employing a highly allusive and intertextual style in his films, Aja’s international reputation is only truly attributable to his success with genre pictures. Aja has become known primarily as a genre director, with references to his French nationality largely downplayed, and although his work certainly engages with the national, his auteurial persona primarily frames him as the newest embodiment of an established and global popular mode. Aja, then, is a postnational auteur figure, whose generic associations have potentially superseded national identity.