bluuebunny/crossref_metadata_2025_split huggingface dataset:
A gastroduodenal artery that branched from the celiac artery in gastrectomy: A rare case of an anatomical variant
Authors: Shimizu Shota , Matsunaga Tomoyuki , Sakano Yu , Makinoya Masahiro , Shishido Yuji , Miyatani Kozo , Kono Yusuke , Murakami Yuki , Hanaki Takehiko , Kihara Kyoichi , Yamamoto Manabu , Tokuyasu Naruo , Takano Shuichi , Sakamoto Teruhisa , Hasegawa Toshimichi , Fujiwara Yoshiyuki 
Published: December 2023

AbstractUnderstanding anatomical anomalies of the branch of the celiac artery for safe gastrectomy is important. We report a case of laparoscopic distal gastrectomy with D1+ lymph node dissection for early gastric cancer with a vascular anatomical anomaly of the celiac artery. A 45‐year‐old woman was referred to our hospital because of early gastric cancer. Computed tomography showed an anatomical variation of the gastroduodenal artery, which branched from the celiac artery. The celiac artery also branched into the left gastric artery, the splenic artery, and the common hepatic artery. Preoperative understanding of an unusual branch of the celiac artery enabled a safe laparoscopic surgery. There were no postoperative complications. The Adachi classification or Michel classification is used for an anatomical anomaly of the celiac artery, but to the best of our knowledge, this case has not been previously classified and is the first reported case.
Interrelatedness of women's health‐behaviour cognitions: A dyadic study of female family members on carrying heavy loads during pregnancy in Nepal
Authors: Tomberge Vica Marie Jelena , Shrestha Akina , Meierhofer Regula , Inauen Jennifer 
Published: December 2023

AbstractObjectivesDecisions about reproductive health are often influenced by women's female family members, particularly in low‐resource contexts. However, previous research has focused primarily on individual behavioural determinants. We investigated the interrelatedness of female family members' reproductive health behaviour with a dyadic version of an extended health action process approach. We investigated this for carrying heavy loads during pregnancy and postpartum, a risk factor for reproductive health in many low‐income countries such as Nepal.DesignThis cross‐sectional study included dyads of daughters‐in‐law and mothers‐in‐law in rural Nepal (N = 476, nested in 238 dyads).MethodsDyads of daughters‐ and mothers‐in‐law were surveyed about avoiding carrying heavy loads during pregnancy and postpartum. The effects of a woman's cognitions and her female dyadic partner's cognitions on their intention and behaviour about avoiding carrying loads were estimated using linear mixed models.ResultsThe results showed that a mother‐in‐law's cognitions were related to her daughter‐in‐law's intentions and vice versa. The mother‐in‐law's cognitions were also related to the daughter‐in‐law's behaviour. The mother‐in‐law's self‐efficacy and injunctive norms related to the daughter‐in‐law's intention and behaviour over and above the daughter‐in‐law's own self‐efficacy and injunctive norms.ConclusionFemale Nepali family members' cognitions about carrying heavy loads during pregnancy and postpartum are interrelated. Including female family members in interventions to help women manage their reproductive health in low‐resource populations seems promising. These novel findings add to the growing body of research indicating the importance of including a dyadic perspective when understanding and changing health behaviour.
Mixtures of t$$ t $$ factor analysers with censored responses and external covariates: An application to educational data from Peru
Authors: Wang Wan‐Lun , Castro Luis M. , Li Huei‐Jyun , Lin Tsung‐I 
Published: December 2023

AbstractAnalysing data from educational tests allows governments to make decisions for improving the quality of life of individuals in a society. One of the key responsibilities of statisticians is to develop models that provide decision‐makers with pertinent information about the latent process that educational tests seek to represent. Mixtures of factor analysers (MtFA) have emerged as a powerful device for model‐based clustering and classification of high‐dimensional data containing one or several groups of observations with fatter tails or anomalous outliers. This paper considers an extension of MtFA for robust clustering of censored data, referred to as the MtFAC model, by incorporating external covariates. The enhanced flexibility of including covariates in MtFAC enables cluster‐specific multivariate regression analysis of dependent variables with censored responses arising from upper and/or lower detection limits of experimental equipment. An alternating expectation conditional maximization (AECM) algorithm is developed for maximum likelihood estimation of the proposed model. Two simulation experiments are conducted to examine the effectiveness of the techniques presented. Furthermore, the proposed methodology is applied to Peruvian data from the 2007 Early Grade Reading Assessment, and the results obtained from the analysis provide new insights regarding the reading skills of Peruvian students.
Oral bacterium Streptococcus mutans promotes tumor metastasis through thrombosis formation
Authors: Yu Li , Hong Yuying , Maishi Nako , Matsuda Aya Yanagawa , Hida Yasuhiro , Hasebe Akira , Kitagawa Yoshimasa , Hida Kyoko 
Published: December 2023

AbstractThrombosis is a well‐known cardiovascular disease (CVD) complication that has caused death in many patients with cancer. Oral bacteria have been reported to contribute to systemic diseases, including CVDs, and tumor metastasis. However, whether oral bacteria‐induced thrombosis induces tumor metastasis remains poorly understood. In this study, the cariogenic oral bacterium Streptococcus mutans was used to examine thrombosis in vitro and in vivo. Investigation of tumor metastasis to the lungs was undertaken by intravenous S. mutans implantation using a murine breast cancer metastasis model. The results indicated that platelet activation, aggregation, and coagulation were significantly altered in S. mutans‐stimulated endothelial cells (ECs), with elevated neutrophil migration, thereby inducing thrombosis formation. Streptococcus mutans stimulation significantly enhances platelet and tumor cell adhesion to the inflamed ECs. Furthermore, S. mutans‐induced pulmonary thrombosis promotes breast cancer cell metastasis to the lungs in vivo, which can be reduced by using aspirin, an antiplatelet drug. Our findings indicate that oral bacteria promote tumor metastasis through thrombosis formation. Oral health management is important to prevent CVDs, tumor metastasis, and their associated death.
RNA: The most attractive target in recent viral diseases
Authors: Rabie Amgad M. 
Published: December 2023

AbstractAs an expert in the field of drug design and discovery, I tried, in this up‐to‐date perspective or commentary article, to recap and shed light on the previous and latest revolutionary strategies employed in medicinal and therapeutic chemistry to target the principal viral weapon used by virulent RNA viruses (e.g., the severe acute respiratory syndrome coronavirus 2 “SARS‐CoV‐2”) to infect humans and spread infections, the genomic RNA strands. These strategies act by taking advantage of the weakness points of this attractive bioweapon to disable or attack it (itself), accordingly stop the entire viral reproduction, and effectively end the severe microbial infections such as the coronavirus disease 2019 (COVID‐19). The generation of respective slightly falsely‐weaved RNA strands, either endogenously or exogenously, is the principal key for designing most of these therapeutic approaches.
Systematic review and appraisal of quality, definitions and treatment recommendations of clinical guidelines for glaucoma suspects
Authors: Wu Zhichao , Karunaratne Senuri , Ang Ghee Soon , Martin Keith R. , Downie Laura E. 
Published: December 2023

AbstractBackgroundTo appraise the quality of clinical practice guidelines for glaucoma suspects, and to assess their consistency for how a ‘glaucoma suspect’ is defined and their recommendations for treatment initiation for such individuals.MethodsThis study included all documents that self‐identified as a ‘guideline’ and provided recommendation(s) for the clinical care of glaucoma suspects. The quality of eligible guidelines was assessed using the Appraisal of Guidelines for Research and Evaluation (AGREE) II instrument.ResultsFrom 1196 records retrieved from comprehensive searches and two records manually included, 20 clinical practice guidelines were deemed eligible. Based on an appraisal using the AGREE II instrument, 16 (80%) guidelines had ≤2 domains with scores >66%. Overall, the lowest scoring domains were for applicability, editorial independence and stakeholder involvement. There was relatively poor agreement across the guidelines for what defines a ‘glaucoma suspect’ or ‘primary open angle glaucoma [POAG] suspect’, as well as the recommendations and criteria for treatment initiation in these populations. There was better agreement for the definition and recommendations for treatment initiation for ‘primary angle closure suspects’.ConclusionsThere is substantial room to improve the methodological quality of most current international clinical guidelines for glaucoma suspects. Clinicians should consider this finding when using such guidelines to inform their care of glaucoma suspects. Substantial variation in the definition of a POAG suspect and recommendations for treatment initiation underscores important gaps in the current evidence for the accurate prediction of glaucoma development and treatment effectiveness in these individuals.
Mesenchymal stem cell therapy for Crohn's perianal fistula—a real‐world experience
Authors: White Ian , Yanai Henit , Avni Irit , Slavin Moran , Naftali Timna , Tovi Shifra , Dotan Iris , Wasserberg Nir 
Published: December 2023

AbstractAimRemission rates of medically and surgically treated complex perianal fistulas in Crohn's disease are low. Recently, trials have demonstrated the potential for long‐term remission with local injection of allogeneic adipose‐derived mesenchymal stem cells (darvadstrocel). Our aim was to analyse outcomes from our real‐world experience with this new treatment.MethodsAll patients with Crohn's disease suffering complex perianal fistulas who consecutively underwent administration of darvadstrocel at two centres were followed up and evaluated. Patients were assessed for clinical remission, response, failure, and any complications during follow‐up. The results of all patients with a minimum of 3 months’ follow‐up are presented.ResultsThirty‐three patients with Crohn's disease and complex perianal fistulas were included. Of these, 20 (61%) experienced clinical remission that was maintained for a mean follow‐up of 14 (3–32) months. A total of 24 of 33 (73%) experienced at least 3 months of clinical remission, with four later having recurrence (3–12 months). Among the remaining nine patients who did not experience clinical remission, two (6%) had partial remission (such as one of two fistulas closing), two (6%) showed signs of response but not remission, and five (15%) showed no signs of healing. The mean time to maintained clinical remission was 6 weeks (range 2 weeks to 6 months), and there were no severe adverse events.ConclusionIn this real‐world experience, treatment of Crohn's disease complex perianal fistulas with darvadstrocel had a 61% success rate for maintained clinical remission.
The search for enchantment in times of climate change: Religious or spiritual responses to climate crisis
Authors: Brissman Ive 
Published: December 2023

AbstractPublic discourse and political climate policymaking are based on scientific reports and propose technological solutions to solve the crisis, primarily by changing fossil fuels to renewable energy. Rather than questioning growth and the overuse of natural resources—which has been at the core of green concern for decades—green growth is the motor in an economy that aims for continuous economic spin, driven by new technological innovations that will enable us to go on as before, simply by replacing energy sources. It is no surprise that in such a discourse, the alternative voices—such as religious or spiritual responses—are left out, but to go from that and conclude that no such voices exist would be to rush to conclusions. I suggest that if we want to search for enchantment in times of climate change, we must look elsewhere. Searching for these voices means leaving the discourse framed by scientific rationalistic measurements because we can find an enchanted alter‐tale beyond this disenchanted tale. In this article, I account for voices from my field and answer the question: What motivates people to turn to spirituality in times of climate change?
Weight loss and treatment patterns in a real‐world population of adults receiving liraglutide 3.0 mg for weight management in routine clinical practice in Switzerland (ADDRESS study)
Authors: Schultes Bernd , Timper Katharina , Cavadini Gionata , Rüh Josefine , Gerber Philipp A. 
Published: December 2023

AbstractAimTo assess weight loss associated with liraglutide 3.0 mg treatment in individuals with obesity (body mass index [BMI] ≥30 kg/m2) or overweight (BMI > 27 to <30 kg/m2) in a reimbursed, real‐world setting in Switzerland.Materials and MethodsADDRESS was a non‐comparative, multicentre, retrospective exposure cohort study in Switzerland, examining weight loss in individuals with obesity or overweight whose treatment was reimbursed (divided into BMI subgroups) or non‐reimbursed. The primary outcomes were proportions of participants in the reimbursed cohort achieving predefined weight loss targets with liraglutide 3.0 mg at Week 16 (≥5% and ≥7% for the lower BMI [28 to <35 kg/m2 with weight‐related comorbidities] and higher BMI [≥35 kg/m2] subgroups, respectively) and Month 10 (additional ≥5% from Week 16; per Swiss reimbursement criteria).ResultsThe full analysis set comprised 258 individuals (195 reimbursed; 63 non‐reimbursed). In the reimbursed cohort, 139 individuals (71.3%) achieved their weight loss targets at Week 16. Of individuals who met the Week‐16 criteria, 43.2% attained an additional 5% weight loss at Month 10. In 162 individuals for whom data were recorded at Month 10, the mean (standard deviation) relative weight loss from baseline to Month 10 was −12.4% (6.4%).ConclusionsAlthough reimbursement criteria may be difficult to achieve, particularly the additional weight loss of 5% from Week 16 to Month 10, a clinically relevant overall weight loss from baseline to Month 10 was shown in most individuals with obesity or overweight who received liraglutide 3.0 mg.
Performance of Felixer devices when faced with captive‐held Spotted‐tailed Quolls: Do they pose a risk to an endangered marsupial carnivore?
Authors: Claridge Andrew W. , Ballard Guy A. , Luck Elliott A.G. , Fleming Peter J.S. 
Published: December 2023

SummaryFeral Cats are widespread and common across Australia, preying upon a wide diversity and large quantity of vertebrates and invertebrates. Curbing their impacts demands developing new control methods, as existing techniques are only usually partially successful. One such new method is the Felixer, a device that uses a combination of sensors to differentiate Feral Cats from other fauna before delivering a toxic gel to the fur of its target. Subsequently, this gel is then groomed and ingested. Before the Felixer can be more widely adopted, however, it is important to understand its target specificity. In a series of pen trials, we examined the ability of Felixer devices to discriminate Spotted‐tailed Quolls, a cat‐sized marsupial carnivore high on the list of species of concern. Over several weeks, multiple Spotted‐tailed Quolls were each individually placed in pens with Felixers programmed in photograph only mode to take photographs only when sensors were triggered. Overall, there were almost 4000 detection events where Quolls passed in front of these devices and photographs taken. Nearly 1300 of these detections showed Quolls in a perpendicular or side‐on position, ideally placed for the Felixer sensor arrays. Despite this exposure, there were no instances where the Felixer devices indicated that they would have activated on Quolls, had they been in lethal mode. This finding adds to recently published work in Tasmania, that also showed Quolls were highly unlikely to be incorrectly identified. Nevertheless, further studies of non‐target discrimination by the Felixer device on other species of native wildlife is vital before they are made fully operational. This is particularly the case on the eastern seaboard of the country where the device has not yet been widely used and much remains to be learned about how they perform when faced with different species.
Decoding immunogenic cell death from a dendritic cell perspective
Authors: Janssens Sophie , Rennen Sofie , Agostinis Patrizia 
Published: December 2023

SummaryDendritic cells (DCs) are myeloid cells bridging the innate and adaptive immune system. By cross‐presenting tumor‐associated antigens (TAAs) liberated upon spontaneous or therapy‐induced tumor cell death to T cells, DCs occupy a pivotal position in the cancer immunity cycle. Over the last decades, the mechanisms linking cancer cell death to DC maturation, have been the focus of intense research. Growing evidence supports the concept that the mere transfer of TAAs during the process of cell death is insufficient to drive immunogenic DC maturation unless this process is coupled with the release of immunomodulatory signals by dying cancer cells. Malignant cells succumbing to a regulated cell death variant called immunogenic cell death (ICD), foster a proficient interface with DCs, enabling their immunogenic maturation and engagement of adaptive immunity against cancer. This property relies on the ability of ICD to exhibit pathogen‐mimicry hallmarks and orchestrate the emission of a spectrum of constitutively present or de novo‐induced danger signals, collectively known as damage‐associated molecular patterns (DAMPs). In this review, we discuss how DCs perceive and decode danger signals emanating from malignant cells undergoing ICD and provide an outlook of the major signaling and functional consequences of this interaction for DCs and antitumor immunity.
Do all job changes increase wellbeing?
Authors: Longhi Simonetta , Nandi Alita , Bryan Mark , Connolly Sara , Gedikli Cigdem 
Published: December 2023

AbstractWe provide a comprehensive framework, based on person–environment fit, for evaluating the relationship between types of job change and wellbeing, and estimate it using fixed‐effects methods applied to UK longitudinal data. Changing job is associated with large swings in job satisfaction, but not all job changes are equal. Changes in workplace are associated with increased job satisfaction only when they are associated with a change in job role. The largest associations are for changing employers. These associations extend beyond job satisfaction to mental health and, to a lesser extent, life satisfaction. Changes in broader wellbeing are especially pronounced for women.
Impact of antiviral therapy on short‐ and long‐term outcomes of patients with chronic obstructive pulmonary disease after influenza infection
Authors: Wallick Christopher , To Tu My , Korom Stephan , Masters Henry , Wu Ning , Moawad Dalia , Hanania Nicola A. 
Published: December 2023

AbstractBackgroundRespiratory complications often accompany influenza in patients with chronic obstructive pulmonary disease (COPD). In this retrospective study, we quantified the impact of antiviral therapy on exacerbations, healthcare resource utilization (HRU), and costs in patients with COPD across 5 influenza seasons.MethodsUsing claims data from US MarketScan® databases, we identified patients with COPD who had an influenza diagnosis during the 2012–2016 influenza seasons. Patients who received a neuraminidase inhibitor within 48 h of diagnosis (N = 4134) were identified and propensity score–matched 1:1 to a comparator cohort of untreated patients. We determined COPD‐ and pneumonia‐related HRU and costs during month 1, each subsequent quarter, and months 2–13.ResultsAntiviral‐treated patients had a significantly lower frequency of COPD‐related outcomes than untreated patients during all periods (exacerbations: 10.4% vs 18.2% [month 1] and 17.7% vs 24.2% [months 2–13]; inpatient visit: 2.5% vs 7.9% [month 1] and 3.8% vs 6.7% [months 2–13]; P < 0.0001, all comparisons). Treated patients also had significantly lower outpatient and emergency department (ED) visits beyond month 1. Pneumonia‐related inpatient, ED, and outpatient visits were significantly lower in antiviral‐treated patients than in untreated patients over all periods (P < 0.0001, all comparisons). In all HRU categories, COPD‐ and pneumonia‐related costs were significantly lower in treated patients over all periods (month‐1 ED visit costs were higher).ConclusionsAntiviral treatment in patients with COPD and influenza is associated with significantly lower HRU and costs in the postinfection month and for an entire year following infection compared with untreated patients.
In situ growth of CuO on porous geopolymer spheres as green catalysts for enhanced peroxymonosulfate‐activated degradation of Orange I
Authors: Li Weizhuo , Wang Liya , Bai Chengying , Ren Yueming , Colombo Paolo 
Published: December 2023

AbstractIn this study, in situ growth of CuO on the surface of porous geopolymer catalyst spheres (GC) was prepared through a simple method for the activation of peroxymonosulfate (PMS) to degrade Orange I (OI) in water. GC‐0.01 exhibited an excellent performance with more than 95% degradation of OI within 30 min. The effects of PMS concentrations, catalyst dosage, Cl−, HCO3−, and humic acid (HA) on OI degradation in the GC‐0.01/PMS system were systematically investigated. The study of the mechanism showed that PMS combined with the catalyst to generate complexes on the surface of the spheres, which could degrade OI through an electron transfer pathway. In addition, a variety of reactive oxygen species, mainly 1O2, were also present in the GC‐0.01/PMS system, which could also degrade OI. This work provides new insight into the application of oxide‐modified geopolymers in the activation of PMS for water purification applications.
The role of lipid dysregulation in gestational diabetes mellitus: Early prediction and postpartum prognosis
Authors: Zhang Ziyi , Zhou Zheng , Li Hong 
Published: December 2023

ABSTRACTGestational diabetes mellitus (GDM) is a pathological condition during pregnancy characterized by impaired glucose tolerance, and the failure of pancreatic beta‐cells to respond appropriately to an increased insulin demand. However, while the majority of women with GDM will return to normoglycemia after delivery, they have up to a seven times higher risk of developing type 2 diabetes during midlife, compared with those with no history of GDM. Gestational diabetes mellitus also increases the risk of multiple metabolic disorders, including non‐alcoholic fatty liver disease, obesity, and cardiovascular diseases. Lipid metabolism undergoes significant changes throughout the gestational period, and lipid dysregulation is strongly associated with GDM and the progression to future type 2 diabetes. In addition to common lipid variables, discovery‐based omics techniques, such as metabolomics and lipidomics, have identified lipid biomarkers that correlate with GDM. These lipid species also show considerable potential in predicting the onset of GDM and subsequent type 2 diabetes post‐delivery. This review aims to update the current knowledge of the role that lipids play in the onset of GDM, with a focus on potential lipid biomarkers or metabolic pathways. These biomarkers may be useful in establishing predictive models to accurately predict the future onset of GDM and type 2 diabetes, and early intervention may help to reduce the complications associated with GDM.