bluuebunny/crossref_metadata_2025_split huggingface dataset:
Surgical outcomes of sinonasal malignancies among endoscopic surgery, open surgery and combined surgery: an 18-year experience
Authors: Promsopa Chakapan , Tangchawalit Tipmana , Kirtsreesakul Virat , Prapaisit Usaporn , Pitathawatchai Pittayapon 
Published: October 2023

Abstract

Objective
Sinonasal malignancies are complex neoplasms that necessitate careful surgical management. This study aimed to compare the outcomes of three surgical approaches: endoscopic surgery, open surgery, and a combination of both in treating sinonasal malignancies.
Results
Among the 59 patients included, there were 31 males and 28 females. The patients were separated into 3 groups: 13 patients underwent an endoscopic approach, 35 patients underwent an open approach, and 11 patients underwent a combined surgery. The 5-year overall survival rate was 50%. The 5-year disease-specific survival was 76%, 47% and 55% (p value = 0.066) for the endoscopic approach, combined surgery and open surgery groups, respectively, with no statistically significant differences among all approaches. The most frequent histotypes were squamous cell carcinoma (37%), salivary gland-type carcinoma (22%), esthesioneuroblastoma (11%), and adenocarcinoma (10%). Patients in the endoscopic approach group had the shortest length of hospital stay, with a statistically significant difference (p value < 0.001). Additionally, the overall 5-year survival in all 59 patients was 50%. The 5-year disease-specific survival was not significantly different among all groups (p value = 0.066), and there were no statistically significant relationships between surgical outcomes and survival when using multivariate regression analysis.
Capitella teleta gets left out: Possible evolutionary shift causes loss of left tissues rather than increased neural tissue from dominant-negative BMPR1
Authors: Webster Nicole B. , Meyer Néva P. 
Published: October 2023

Abstract

Background: The evolution of centralized nervous systems (CNSs) a fascinating and complex topic; further work is needed to understand the genetic and developmental homology between organisms with a CNS. Research into a limited number of species suggests that CNSs may be homologous across Bilateria. This hypothesis is based in part on similar functions of BMP signaling in establishing fates along the dorsal-ventral (D-V) axis including limiting neural specification to one region of ectoderm. From an evolutionary-developmental perspective, the best way to understand a system is to explore it in a wide range of organisms to create a full picture.
Methods: Here we expand our understanding of BMP signaling in Spiralia, the third major clade of bilaterians, by examining phenotypes after expression of a dominant-negative BMP Receptor 1 and after knock-out of the putative BMP antagonist Chordin-like using CRISPR/Cas9 gene editing in the annelid Capitella teleta (Pleistoannelida).
Results: Ectopic expression of the dominant-negative Cte-BMPR1 did not increase CNS tissue or alter overall D-V axis formation in the trunk. Instead, we observed a unique asymmetric phenotype: a distinct loss of left tissues including the left eye, brain, foregut, and trunk mesoderm. Adding ectopic BMP4 early during cleavage stages reversed the dominant-negative Cte-BMPR1 phenotype, leading to a similar loss or reduction of right tissues instead. Surprisingly, a similar asymmetric loss of left tissues was evident from CRISPR knock-out of Cte-Chordin-like but concentrated in the trunk rather than the episphere.
Conclusions: We further solidify the hypothesis that the function of BMP signaling during establishment of the D-V axis and CNS is fundamentally different in at least Pleistoannelida, possibly in Spiralia, and is not required for nervous system delimitation in this group. Our results support hypotheses of either multiple evolutionary origins of CNSs across Bilateria or divergence in the molecular mechanisms of CNS specification and D-V axis formation in annelids.
Long-term effects of sustained regular medication in hypertensive patients in Yunnan, China: a cohort study of 5 years follow up
Authors: Ma Min , Wang Huadan , Pang Linhong , Guo Zihong , Xia Yu , Sun Manli , Zhao Yajing , Shi Yi , Wu Xia , Song Junjie , Zhu Qiuyan , Duo Lin , Wang Zhongjie , Tang Mingjing , He Liping 
Published: October 2023

Abstract
Background The relationship between different grades of compliance to antihypertensive medication and blood pressure(BP) control rate remains unclear. The study underscores the relationship that long-term compliance with regular antihypertensive medication to improve rates of BP control.Methods Using 5-year follow-up data, hypertensive patients were categorized into "poor", "intermittent", and " sustained" groups according to tertiles of antihypertensive medication compliance, and the BP control rates of the three groups were compared.Then, the robust variance Poisson regression model estimated the association between three groups and the number of referrals. Kaplan-Meier calculated the cumulative risk of onset and survival probability of cardiovascular events from three medication compliance groups.Results A total of 1254 patients were enrolled and annual follow-up studies of 992, 1218, 1121, 1066 and 999 hypertensive patients were conducted from 2018 to 2022. From baseline to last follow-up, systolic BP declined from 154.69 ± 20.90 mmHg to 137.48 ± 12.44 mmHg and diastolic BP from 84.08 ± 12.80 mmHg to 79.50 ± 7.88 mmHg (p < 0.01). All three groups showed a significant improvement in BP control rates after management, especially the persistence group which reached 70% in 2022(p < 0.01). The number of referrals from the poor group was 11.5% higher than the sustained group (IRR = 1.115,95% CI:1.043 to1.193). The survival probability in the sustained group was the highest and kept at 0.950 at the end of 5 years.Conclusions Long-term high-grade compliance with antihypertensive medications significantly improves BP control rates and reduces the risk of cardiovascular disease (CVD) events and death.
Advancement Area Control Technology for High Mine Pressure Dynamic Disasters in Thick and Hard Roofs
Authors: Zheng Kaige 
Published: October 2023

Abstract
The western mining area exhibits the superimposed development of a thick and hard roof under the continental sedimentation of multiple ancient rivers. In this case, the fully mechanized caving working face with a large mining height has a high stope pressure, which induces rock burst, mine earthquake, and hurricane in the goaf. To determine the fracture evolution characteristics of overlying strata in a fully mechanized caving mining with a large mining hard roof height, this study investigated the disaster mechanism of hard roof strata that undergo a large “cantilever beam” collapse and produce fracture impact energy. The study was based on the cantilever beam fracture theory, and the UDEC discrete element numerical simulation was used. According to the concept of partition weakening control of a hard roof, an advance weakening technology for staged fracturing of a hard roof was proposed, a mechanical model for a reasonable hanging length of a hard roof was established, and a quantitative formula for determining a reasonable hanging length of a hard roof was developed. Fracturing models under different crustal stress conditions were analyzed, including the ellipsoid fracture network perpendicular to the direction of the working face, the horizontal fracture surface network perpendicular to the direction of the working face, and the near-linear fracture surface dominated by vertical fractures. The first and second models were effective governance models for hard roof disasters. The test was performed in a typical working face, and the results showed that the average periodic weighting step of the roof after fracturing weakening decreased from 18.7 m to 8.6 m, and the weighting strength decreased by 21.67%. These results indicate effective prevention and control of high-mining-pressure disasters in a thick and hard roof. The thick and hard roof was transformed into multiple small blocks by using open-hole staged hydraulic fracturing, resulting in significantly reduced accumulated energy and energy loss during fracturing. In this way, the partition and segmented controllable fracturing length collapse of the thick and hard roof was realized, facilitating the transfer and dissipation of the roof stress as well as the effective control of dynamic disasters. Under the fracturing effect, the caving pattern and breaking degree of the near-field, low-level thick and hard roof were effectively changed, resulting in an improved scope of the working face caving zone and increased gangue filling degree in the goaf. Hence, effective suppression of the far-field strata subsidence and surface subsidence was achieved. This study provides a technical model support for the synergistic control of high-mining-pressure dynamic disasters, mine earthquakes, and surface subsidence in hard roofs.
Response spectrum-based analysis of airborne radar random vibration and multi-point control improvement
Authors: Liu Jie , Liu Zezheng , Chen Wanqian , Lv Jing , Jiang Zixuan , Pang Jiahao , Du Libin 
Published: October 2023

Abstract
During the flight of a UAV, the LiDAR device undergoes random vibrations due to the changing flight attitude and wind speed conditions of the UAV. It is important to control the frequency and amplitude of the vibrations within a reasonable range by means of a damping structure. As the vibrations caused by various factors during flight are random and non-linear, this paper innovates the analysis principle and damping control means for the random vibrations of airborne optoelectronic devices. The response spectrum analysis theory is used to establish the shock response spectrum, and an optimised and improved recursive digital filtering method is used to fit the frequencies of random vibration to the synthetic shock response. Considering the uncertainty of the vibration excitation signal, a virtual excitation method is used for the first time to simulate the random vibration to which the radar may be subjected in the air, and to simplify the calculation steps. The shock plate structure is designed using a multi-point control method to innovate a passive response to the random excitation. Finally, a modal analysis of the synthesised shock response was carried out to verify that the first six modal frequencies were controlled to within 220Hz to achieve frequency reduction and the amplitudes were controlled to within 0.5mm in the three xyz directions to achieve vibration damping.
Multi-objective optimization of FSW variables on joint properties of AA5754 aluminum alloy using Taguchi approach and grey relational analysis
Authors: sobhy saleh , Elbadawi Rehab E , Zoalfakar said 
Published: October 2023

Abstract
The friction stir welding (FSW) process was applied to butt-weld AA5754 plates, and the joints of each weld case were identified by their tensile strength, hardness, and impact toughness. The combined effects of the process variables rotation speed, welding speed, and tilt angle have been evaluated in the present study using Taguchi's design of experiments approach and grey relational analysis (GRA). A multi-objective optimization approach (Taguchi method and GRA) was used to optimize and rank the process variables. The developed models are evaluated for sufficiency, and the most significant terms are found using the ANOVA approach. The results of the ANOVA showed that the rotational speed has a maximum contribution of 55.24%, 59%, and 46.27% in obtaining the optimal values of tensile strength, hardness, and impact toughness, respectively. Finding an optimal parameter that offers the maximum value of all replies requires the use of the GRA and Taguchi Technique by Similarity to Suitable Solution. The two methods provide the same results, and the optimal conditions are a rotational speed of 1000 rpm, a welding speed of 60 mm/min, and a tilt angle of 2.5 degrees. The optimal values for tensile strength, hardness, and impact toughness, respectively, were found to be 136 MPa, 85.25 HV, and 13 J.
Molecular Characterization of an Outbreak-involved Bacillus anthracis Strain Confirms the Spillover of Anthrax from West Africa
Authors: Wang Shuchao , Suluku Roland , Jalloh Mohamed B. , Samba Ahmed F. , Jiang Baogui , Xie Yubiao , Harding Doris , Zhang Mengyao , Sahr Foday , Sesay Mahmud E. , Squire James S. , Vandi Mohamed A. , Kallon Moinina N. , Zhang Shoufeng , Hu Rongliang , Zhao Yuee , Mi Zhiqiang 
Published: October 2023

Abstract
Background
Anthrax, a zoonotic disease caused by the spore-forming bacterium Bacillus anthracis, remains a major global public health concern, especially in countries with limited resources. Sierra Leone, a West African country historically plagued by anthrax, has almost been out of report on this disease in recent decades, possibly due to limitations in diagnostic capabilities. In this study, we described a large-scale anthrax outbreak affecting both animals and humans and attempted to characterize the pathogen using molecular tools.
Methods
The causative agent of the animal outbreak was identified using the nanopore sequencing technique. Confirmation of suspected cases of cutaneous anthrax in humans, identified through active surveillance, was conducted using qPCR targeting both the chromosome and two virulent plasmids. Full-genome sequencing was accomplished by combining long-read and short-read sequencing methods. Subsequent phylogenetic analysis was performed based on the full-genome single nucleotide polymorphisms.
Results
The outbreak in Port Loko District, Sierra Leone, led to the death of 233 animals between March 26th and May 16th, 2022. We ruled out the initial suspicion of Anaplasma species and successfully identified B. anthracis as the causative agent of the outbreak. As a result of the government's prompt response, out of the 49 suspected human cases identified during the one-year active surveillance, only six human cases, all within the first month after the official declaration of the outbreak, were confirmed. The phylogenetic analysis indicated that the BaSL2022 isolate responsible for the outbreak was positioned in the A.Br.153 clade within the TransEuroAsian group of B. anthracis.
Conclusions
The anthrax outbreak identified in this study was unprecedented in scale in Sierra Leone. With regard to the shared predicament, the utilization of nanopore sequencing and molecular techniques to identify unknown diseases in Sierra Leone has provided valuable insights into emergency preparedness in similar nations. The A.Br.153 clade, where BaSL2022 was phylogenetically placed, is distinct from the existing West African lineages but may have been prevalent in a large area of West Africa for a long period and undergone evolutionary changes to adapt to novel geographical environments, as evidenced by the spillover of this strain to the United Kingdom and United States.
Graphical Abstract
Analysis of the Genome of Chromium-resistant Serratia sp. CM01 and Chromium Metabolism Characteristics of the ChrA1-Srpc Gene
Authors: Wang Mengjia , Li Xinglong , Yin Qi , Wu Yanqing , Xiao Hong 
Published: October 2023

Abstract
Objective: Serratia sp. CM01 is a naturally domesticated strain with chromium (Cr) resistance and Cr(VI) reduction ability isolated from a Cr-enriched environment. The genome of Serratia sp. CM01 was sequenced and analysed to identify key genes involved in chromium metabolism. Corresponding engineered bacteria associated with special metabolic features were constructed to further study the function of these genes and their encoded proteins in chromium metabolism.
Methods: The whole genome of Serratia sp. CM01 was sequenced, and genes involved in chromium metabolism were analysed. The ChrA1 and Srpc genes were selected and introduced into E. coli using the prokaryotic expression vector pET-28a. The target proteins were identified using sodium dodecyl sulphate‒polyacrylamide gel electrophoresis (SDS‒PAGE) and Western blotting. Chromium tolerance and removal tests were used to assess the chromium metabolic capabilities of the engineered bacteria.
Results: The results of genome sequencing revealed that the genome size of Serratia sp. was 4,902,254 bp, from which 12 genes involved in chromium metabolism were screened. The ChrA1 and Srpc genes were chosen, and three engineered bacteria (eChrA1, eSrpc, and eCS) were successfully constructed. The growth of the three engineered bacteria showed no difference under Cr(VI)-free circumstances (P > 0.05). In the presence of Cr(VI), the viable bacterial cell mount during the stabilization phase was eCS > eChrA1 > eSrpc, and the tolerance and removal rate of Cr(VI) was ranked eCS > eChrA1 > eSrpc.
Conclusion: The genome of Serratia sp. CM01 contains genes related to chromium metabolism, such as NemA, ChrA1, Srpc and FieF. The ChrA1 and Srpc gene-encoded proteins confer Cr(VI) resistance to engineered bacteria, but the specific mechanism of chromium resistance remains to be further studied. eChrA1 has a stronger anti-Cr(VI) ability than eSrpc. The eCS-engineered bacterial strain with ChrA1 and Srpcgenes was more resistant to hexavalent chromium, and it has the potential to handle Cr(VI) pollution in the virtual environment.
Fault-tolerant Echo State Networks for Mobile Network Traffic Prediction
Authors: Sun Xiaochuan , Gao Jiahui , Wang Yu , Li Yingqi , Feng Yingqiao 
Published: October 2023

Abstract
Network traffic prediction is widely recognized as a potential solution for many functions of network security and management. Currently, numerous neural networks (NNs) are used in network traffic prediction tasks. When errors occur in the computational units implemented in NNs due to the effects of hardware failures, the results of arithmetic operations can be altered, and the prediction results may be affected by errors. This is unacceptable when NNs are used for network traffic prediction, because erroneous prediction results may lead to network congestion, uneven resource allocation, and other problems. Therefore, for NNs operating on mobile edge devices, an effective fault tolerance scheme needs to be embedded. A fault-tolerant model for fixed-type neuron failures in echo state networks (FtESN), is proposed in this paper, to improve its reliability in mobile network traffic prediction tasks. There are three specific contributions as follows: 1) We model the fixed-type faulty neurons and introduce the concept of degree for indexing. 2) A simple fixed fault tolerance mechanism is proposed for these faulty neurons. 3) The boundary conditions for reservoir neuron fault tolerance are proved by mathematical theoretical derivation. Experimental results show that the method is effective in recovering performance from fault patterns in terms of prediction accuracy, frequency-domain analysis, statistical distribution comparison, and short-term memory capacity (MC).
Trace Elements Determination and Health Risk Assessment of Groundwater Sources in Kumasi, Ghana
Authors: Peasah Michael Yaw , Awewomom Jonathan , Osae Richard , Agorku Eric Selorm 
Published: October 2023

Abstract

Human health and socioeconomic sustainable development are inextricably linked to water quality. Trace element (TE) contamination in groundwater is a key factor for health risk assessment and one of the environmental challenges linked with Ghana’s sustainable development. This study aims to investigate TEs concentrations in groundwater used for drinking and domestic purposes and their potential health risk in the Kumasi Metropolis using multivariate statistics. In the study, 23 groundwater samples were analyzed for 32 TEs using Perkin Elmer Nexion 2000 Inductively Coupled Plasma Mass Spectrometer (ICP-MS). The study revealed that the concentration of some trace and toxic elements such as Al, Cu and Pb exceeded their corresponding WHO permissible standards. Hazard index (HI) values and total likely cancer risk (TLCR) values computed for non-carcinogenic and carcinogenic health risk indicate that 91.3% of the total sampling sites presented health concerns to adults and children. The mean TLCR values associated with exposure to carcinogenic metals via ingestion of groundwater samples were estimated to be 2.09 × 10− 4 and 4.44 × 10− 4 for adults and children respectively. Exposure through ingestion pathway was found to be more risky compared to dermal contacts. Children are particularly vulnerable to these health hazards. Pearson correlation (PC) matrix, principal component analysis (PCA) and hierarchical cluster analysis (HCA) suggested that sources of TEs in the groundwater are attributed to both anthropogenic and geogenic factors.
Equity in the Advanced Care at Home Model In an Integrative Healthcare System
Authors: Mashaw Arsheeya , Snyder Gregory 
Published: October 2023

Abstract

Advanced Care at Home (ACAH) provides hospital-level care as a substitute for traditional facility-based hospital care. However, there are still concerns regarding equity of care to different socioeconomic groups for this model of care. This retrospective cohort study compared socioeconomic indicators between typical hospital care and an ACAH model in an integrated healthcare system. By utilizing demographics, Neighborhood Deprivation Index (NDI), Medical Financial Aid (MFA) status, and insurance status as proxies for socioeconomic status, our data suggests that care was provided at similar rates to traditional hospital care regardless of age, race, ethnicity, insurance status or degree of social deprivation. In patients in the 4th of 5 NDI quintiles (higher socioeconomic needs), a higher percentage were treated in the ACAH model (20.4% vs. 14.2%; P < 0.00001). 16.9% of Kaiser Permanente at Home patients had applied for MFA within 6 months of admission compared with 13.5% of hospital patients (P = 0.00001).
A comparative study of cyanoacrylate-based tissue adhesive and surgical sutures on marginal flap stability following coronally advanced flap
Authors: Pabst Andreas , Becker Philipp , Kuchen Robert , Schumann Sven , Kasaj Adrian 
Published: October 2023

Abstract
Introduction:
The present study evaluated the biomechanical characteristics of cyanoacrylate-based tissue adhesive (TA) compared to surgical sutures in coronally advanced flap (CAF) procedures using an ex-vivo model.
Material and Methods
Thirty-six half pig mandibles were divided into 3 groups, n = 12 each: (I) CAF fixed with sutures (sling and tag suture technique), (II) CAF fixed with TA, and (III) CAF fixed with sutures and TA. At mandibular molars, gingival recession defects extending 3 mm apical to the cemento-enamel junction (CEJ) were created. CAF procedures were performed using a split-full-split approach, with coronal advancement of the flap to 1 mm above the marked CEJ and stabilization according to the respective group I-III. Marginal flap stability against pull-of forces (maximum tensile force) was measured with an universal material testing machine until the CEJ became visible.
Results
The comparison between the groups I-III demonstrated a significantly increased maximum tensile force for the TA (II) compared to the suture group (I) (p < 0.001). A significantly increased maximum tensile force was found for the suture and TA (III) compared to the suture group (I) (p < 0.001). There was also a significantly increased maximum tensile force in the suture and TA (III) compared to the TA group (II) (p < 0.001).
Conclusion
The results suggest that cyanoacrylate-based TA can increase marginal flap stability compared to sutures in CAF procedures.
Clinical Relevance:
Cyanoacrylate-based TA can be considered as a useful and valuable adjunct to conventional suturing techniques in periodontal plastic surgery, especially in cases where high flap stability is required.