bluuebunny/crossref_metadata_2025_split huggingface dataset:
A Comprehensive Review of the Advancement in Omic Technologies in the Field of Drug Discovery and Development
Authors: Chauhan Mridula , Kumar Shivansh , Biswas Arpon , Kumar Mukesh , Verma Sarvesh Kumar , Mishra Anjali , Singh Vaishali , Bisen Amol Chhatrapati , Agrawal Sristi , Choudhury Abhijit Deb , Rayiti Ramakrishna , Bhatta Rabi Sankar 
Published: February 2024

:
Discovering new drugs is time-consuming and expensive and involves many different
tools from various domains. Numerous omic technologies, such as genomics, transcriptomics,
proteomics, and metabolomics, have been created to speed up the process. Leveraging genetic and
genomic insights, these methodologies play a pivotal role. Genetic insights aid in target identification, prioritization, and the prediction of drug outcomes. Gene expression data informs drug discovery, while proteomics uncovers targets and facilitates high-throughput profiling. Enhancing
drug efficacy necessitates mechanistic insights into downstream effects, enabling side effects and
resistance prediction. Early-stage drug discovery now extensively employs diverse metabolomics
platforms. This review underscores the recent strides of omic technologies in drug discovery, affirming their role in enhancing drug viability and regulatory approval. The emphasis lies on the
latest advancements in genomics, transcriptomics, proteomics, and metabolomics, collectively
fortifying drug development.
Multicomponent Synthesis of Structurally Diverse Spiroheterocycles using Bio-organic Catalyst in Aqueous Medium
Authors: Verma Asha , Pathak Gargi , Kumar Sandeep , Khatri Vineeta , Chhatwal Rajni Johar , Arya Dinesh Kumar 
Published: February 2024

Background:
MCRs are one of the most significant tools in the synthesis of organic
compounds. MCR is a rapid chemical technique that uses three or more reactants to produce products
that sustain all structural and substructural properties of the initial components. MCRs are
useful in all fields of synthetic chemistry because of their rapid rate of reaction, simple procedure
and excellent yields. We reported an efficient and environmentally friendly domino approach for
the synthesis of spiroheterocycles spiro annulated with indeno[1,2-b]quinoline.

Method:
The spiroheterocycles with privileged heterocyclic substructures have been synthesized
using taurine (2-aminoethanesulfonic acid) as a green, sustainable, bio-organic and recyclable catalyst
in a three-component reaction of isatins, 1,3-diketones, and 1-napthylamine in aqueous media.
The present synthetic method is probably the first report to synthesize spiroheterocycles, spiroannulated
with indeno[1,2-b]quinoline. Furthermore, the approach is valuable because of the excellent
yield that results from the reaction in 15-20 min.

Result:
The optimization of reaction conditions is an important case of efficient synthesis. The
solvent, temperature, time and catalyst loading were all examined. The reusability of the catalyst
was also investigated experimentally. The used catalyst taurine has a high activity as well as good
reusability. The present synthetic protocol will be extended to synthesise a library of hybrid compounds.
The present synthetic approach is cost-effective, and time-efficient with an easy-workup
methodology that gives outstanding yields (80–95%) in 15–20 min.

Conclusion:
Taurine-catalyzed multicomponent reaction is a novel and efficient method for the
synthesis of spiroannulated indeno[1,2-b]quinolines. The high catalytic activity of taurine as a catalyst
with water as a green solvent makes the process environmentally friendly. The special features
of the synthetic protocol include synthetic efficiency, operational simplicity, and reusability of the
catalyst and it is expected to make significant contributions not only to drug discovery studies but
also to pharmaceutical and therapeutic chemistry in view of introducing molecular diversity in the
synthesized molecules.
UCIS4EQ applied to the M7.1 2017 earthquake in Puebla (México)
Authors: Monterrubio-Velasco Marisol , Pienkowska Marta , Bhihe Cedric , Blanco-Prieto Rut , Iglesias Arturo , Puente Josep de la 
Published: February 2024

The Urgent Computing Integrated Services for Earthquakes (UCIS4EQ) is
proposed as a novel Urgent Computing (UC) seismic workflow that focuses
on short-time reports of synthetic estimates of the consequences of
moderate to large earthquakes. UC combines High-Performance Computing
(HPC), High-Performance Data Analytics (HPDA), and optimized solvers to
perform numerical simulations during or immediately after emergency
situations, typically within a few minutes to a few hours. Complex
edge-to-end UC workflows coordinate the execution of multiple model
realizations to account for input and model uncertainties and can
provide decision-makers with numerical estimates of the outcomes of
emergency scenarios, such as earthquakes addressed by UCIS4EQ.
UCIS4EQ is being driven toward operational maturity thanks to the
technological and scientific developments within the eFlows4HPC project.
Based on containerised micorservices, this workflow is fully
orchestrated by the PyCOMPSs workflow manager to automatically prepare
and manage physics-based deterministic simulation suites for rapid
synthetic results. Through pre-computed and on-the-fly simulations,
UCIS4EQ delivers estimates of relevant ground motion parameters, such as
peak ground velocity, peak ground acceleration, or shaking duration,
with very high spatial resolution. The physics-based engine includes
pre-trained Machine Learning (ML) models fed with pre-computed
simulation databases, as well as deterministic 3D simulations on demand,
providing results in minutes and hours, respectively. The combined
results, when well-calibrated, could lead to a new generation of ground
shaking maps that complement GMPEs for rapid hazard assessment.
To demonstrate the potential use of UC in seismology, in this work we
show the UCIS4EQ simulation of the M7.1 Puebla earthquake that occurred
in central Mexico on the 19th of September 2017. With a hypocentre at
18.40ºN, 98.72ºW and 57 km depth, the Puebla earthquake was located
about 150 km southeast from Mexico City. Identified as a severe event
(VIII) in the Modified Mercalli Intensity scale, it resulted in a total
of 370 killed and around 6000 injured, as well as structural damages,
downed telephone lines, and ruptured gas mains.
Perfeccionar la preparación y superación de los cuadros educacionales, un reto para la Universidad
Authors: Hernández Fernández Viviana Emérida , Torres Falcón Mairelys de la Caridad , Martínez Mollineda Carlos Martínez Mollineda 
Published: February 2024

La ponencia incursiona en la preparación y superación de los cuadros educacionales en Villa Clara. El objetivo es proponer un modelo que exprese cómo se puede perfeccionar la dirección del proceso de preparación y superación de los cuadros educacionales que facilite alcanzar su liderazgo. Los métodos utilizados: la observación participante, la encuesta, el análisis de documentos y la triangulación metodológica. Del análisis realizado se corroboró la falta de una dirección del proceso, coherente y sistémico partiendo del sistema de trabajo, donde se integran la superación, preparación y trabajo metodológico para lograr una preparación con más calidad que impacte en la gestión de dirección, bajo la dirección integrada de la Universidad y la Dirección Provincial de Educación. Los especialistas valoraron como muy pertinente, adecuado y necesario dicho modelo.
Vinculación de la disciplina ciencias farmacológicas al centro de Ingeniería Genética y Biotecnología de Cuba
Authors: Polo Vega Juan Carlos , González Blanco Ivón , Castro Aldama Jorge , Aldana Velazco Lizet , Amaya Rubén , González Langaney Arlety 
Published: February 2024

La vinculación universidad–empresa constituye una estrategia metodológica para la preparación del talento humano, tanto en el ámbito académico como en el empresarial. Las empresas encuentran en las universidades recursos humanos entrenados en la investigación, con los que perfeccionar la producción existente y desarrollar la I+D con mayor precisión, mientras que la docencia se enriquece por la vinculación de los conocimientos teóricos con la práctica y su aplicación en un entorno real. El objetivo del trabajo es divulgar los principales resultados del vínculo establecido entre la disciplina Ciencias Farmacológicas del Instituto de Farmacia y Alimentos (IFAL) de la Universidad de La Habana y la Dirección de Investigaciones Preclínicas y Experimentación Animal (DIPEA) del Centro de Ingeniería Genética y Biotecnología de Cuba. Entre los logros de mayor impacto se encuentran el diseño y realización en las instalaciones del bioterio de DIPEA de prácticas de laboratorio integradoras de las asignaturas Farmacología, Toxicología y Biofarmacia; la creación e incorporación al currículo optativo de la carrera de una nueva asignatura relacionada con el desarrollo preclínico de productos
farmacéuticos y biotecnológicos, impartida por un conjunto de profesionales de DIPEA; la inserción en DIPEA de grupos de estudiantes para la realización de su práctica laboral y tesis de diploma y el inicio del proceso de categorización como docentes de varios de los profesionales vinculados a esta experiencia. La vinculación establecida contribuyó al mejor desarrollo de las asignaturas de la disciplina y fue reconocida entre los logros del trabajo de DIPEA en el año 2022.
Indigenous Biopreparations and Biocontrol Agents for Growth and Disease Management in Black Pepper Nursery
Authors: Rini C. R. , Ajith P. M. 
Published: February 2024

The present study was carried out at Agricultural Research Station, Thiruvalla, Kerala, India during December, 2020–July, 2021 to evaluate the efficacy of native biocontrol agents and fermented organic preparations viz; fish-jaggery extract, egg-lemon juice extract and jeevamrutha on growth enhancement and suppression of Phytophthora infection in black pepper nursery. The plants were challenge inoculated with Phytophthora capsici at the collar region. The plant growth parameters were recorded before and one month after treatment application. Results showed that a considerable increase in plant height (49.30%) and number of leaves (57.89%) with the application of bacterial antagonists A1 and S2 respectively. Application of fish-jaggery extract increased the shoot girth by 29.6%. Soil application of Trichoderma combined with spraying of bacterial antagonists A1 and S2 also increased the shoot girth considerably. Application of jeevamrutha increased the total leaf area by 49.98% and chlorophyll contents viz. chlorophyll a, chlorophyll b and total chlorophyll was also maximum with this application. Phytophthora infection at collar region was not observed in plants treated with potassium phosphonate and fish-jaggery extract. Application of egg-lemon juice extract, jeevamrutha and bioagents also recorded less infection on collar region. The study indicated the efficacy of fermented organic fertilizers and bioagents in improving plant growth and also in reducing pathogen infection at nursery stage. Hence a combination of native antagonistic microflora and indigenous biopreparations could be effectively utilized in commercial production of healthy planting materials in black pepper nurseries.
EVALUASI JENIS DAN KUALITAS PAKAN SAPI POTONG PETERNAK RAKYAT DI DESA ASTOMULYO, KECAMATAN PUNGGUR, KABUPATEN LAMPUNG TENGAH
Authors: Putri Kejora Asa , Erwanto Erwanto , Farda Fitria Tsani , Muhtarudin Muhtarudin , Tantalo Syahrio , Noer Irmayani , Hasiib Etha' Aziza 
Published: February 2024

Penelitian ini bertujuan untuk mengetahui jenis dan kualitas pakan sapi potong peternak rakyat di Desa Astomulyo, Kecamatan Punggur, Kabupaten Lampung Tengah. Penelitian ini dilaksanakan September—Oktober 2022 di Desa Astomulyo, Kecamatan Punggur, Kabupaten Lampung Tengah. Sedangkan manfaat penelitian diharapkan dapat memberikan informasi mengenai jenis-jenis pakan dan nilai kandungan nutrien bahan pakan yang diberikan di desa tersebut. penelitian ini dilakukan dengan cara wawancara kepada responden, pemilihan responden dilakukan dengan metode purposive sampling dengan pertimbangan memiliki ternak sapi potong minimal 2 ternak dan sudah berternak selama minimal 1 tahun. Sampel pakan diambil di masing-masing peternak responden kemudian dianalisis proksimat. Hasil dari penelitian ini menunjukan bahwa peternak di Desa Astomulyo Kecamatan Punggur, Kabupaten Lampung Tengah menggunakan dua jenis bahan pakan yaitu limbah pertanian yang terdiri dari kulit singkong, kulit nanas, dan onggok sedangkan konsentrat yang terdiri dari konsentrat Inovarm, konsentrat PT Great Giant Livestock (GGL), dan konsentrat Kelompok Ternak Desa Astomulyo, dengan kualitas pakan konsentrat Kelompok Ternak Desa Astomulyo kurang baik yaitu pada kadar protein kasar hanya sebesar 9,73%.
SUPLEMENTASI SOYBEAN MEAL (SBM) TERHADAP KONSUMSI, PRODUKSI SUSU, DAN EFESIENSI RANSUM KAMBING PERAH
Authors: Anwar Choirul , Liman Liman , Muhtarudin Muhtarudin , Qisthon Arif 
Published: February 2024

Penelitian ini bertujuan untuk mengetahui suplementasi terbaik pemberian Soybean Meal terhadap konsumsi, efesiensi ransum, dan produksi susu kambing perah. Penelitian ini dilaksanakan pada Juli-Agustus 2021 yang berlokasi di Telaga Rizky Farm, Kelurahan Yosodadi, Kecamatan Metro Timur, Kota Metro, Provinsi Lampung. Analisis sampel ransum dilakukan di Laboratorium Nutrisi dan Makanan Ternak, Jurusan Peternakan, Fakultas Pertanian, Universitas Lampung. Rancangan percobaan yang digunakan adalah Rancangan Acak Kelompok (RAk) dengan 4 perlakuan dan 3 ulangan. Perlakuan yang diberikan yaitu ransum basal (P0), ransum basal dengan suplementasi 5% Soybean Meal (P1), ransum basal dengan suplementasi 10% Soybean Meal (P2), dan ransum basal dengan suplementasi 15% Soybean Meal (P3). Data yang diperoleh dianalisis menggunakan analisis ragam dengan taraf nyata 5%. Hasil penelitian didapatkan pemberian suplementasi Soybean Meal tidak berpengaruh nyata terhadap efesiensi ransum dan produksi susu (P>0,05) tetapi berpengaruh nyata terhadap konsumsi ransum kambing perah (P<0,05).
Performance of sodium-glucose cotransporter 2 inhibitors in cardiovascular disease
Authors: Khater Jacinthe , Malakouti Sara , Khoury Antoine El , Cortese Bernardo 
Published: February 2024

Aims
The use of sodium-glucose cotransporter 2 inhibitors (SGLT2i) as a new class of drug in treating type 2 diabetes has expanded beyond its original framework. Positive results have been achieved in reducing symptoms in patients with cardiovascular disease (CVD). The aim of this article is to present an in-depth review of the basic principles of this class of medications and how it has brought benefits to patients affected particularly by heart failure.

Methods
Following a thorough PubMed search, this review includes 62 studies published between 2015 and 2023. Keywords searched included ‘sodium-glucose cotransporter 2 inhibitors’, ‘cardiovascular disease’, ‘heart failure’, ‘chronic kidney disease’, and ‘type 2 diabetes’. The most recent and comprehensive data were used.

Results
Positive results have been achieved in reducing symptoms in patients with CVD. SGLT2 inhibitors have also been shown to be useful in other contexts such as nonalcoholic fatty liver disease (NAFLD) by reducing liver fat accumulation, kidney benefits by improving body weight and vascular endothelium, improving eGFR, and reducing progression to end stage kidney disease (ESKD). SGLT2 inhibitors are also effective in reducing the need for heart failure hospitalizations and the risk of serious cardiac adverse events, including cardiovascular and all-cause mortality, in patients with reduced or preserved left ventricular (LV) ejection fraction and in acute or decompensated settings.

Conclusion
SGLT2 inhibitors have evolved into metabolic drugs because of their multisystem action and are indicated for the treatment of all spectrums of heart failure, type 2 diabetes, and chronic kidney disease.
PENDAPAT PENGGUNA JALAN TOL JABODETABEK TENTANG MULTI LANE FREE FLOW
Authors: Sunartio Victoria , Putranto Leksmono Suryo 
Published: February 2024

With the toll road, people's mobility becomes easier. The large number of people using toll roads makes the number of vehicles increase. This often causes congestion that occurs when approaching the toll booth, this congestion occurs because the capacity of vehicles arriving exceeds the service capacity of the toll gate. MLFF is a technology that allows toll road drivers to pay without stopping at toll booths. This study aims to find out the public's perception if the toll payment system changes to the MLFF payment system and the success of MLFF if implemented on the Jabodetabek toll road. The research was compiled using literature studies and quantitative methods and data collection was carried out by distributing questionnaires to Jabodetabek toll road users. The results of the analysis show that the majority of toll road users agree if MLFF is implemented on Jabodetabek Toll Roads and agree on the opinion that implementing MLFF can reduce congestion that occurs when approaching the toll gate. However, the transition process will require good socialization from the government and public acceptance of this new payment system.

Dengan adanya jalan tol mobilitas masyarakat menjadi semakin mudah. Banyaknya masyarakat yang menggunakan jalan tol membuat jumlah kendaraan yang melalui jalan tol semakin banyak. Hal ini sering menyebabkan kemacetan yang terjadi ketika mendekati pintu tol, kemacetan ini terjadi karena kapasitas kendaraan yang datang melebihi kapasitas pelayanan pintu tol. MLFF merupakan suatu teknologi yang memungkinkan pengendara jalan tol membayar tanpa berhenti di pintu tol. Penelitian ini, bertujuan untuk mengetahui persepsi masyarakat apabila sistem pembayaran tol berubah menjadi sistem pembayaran MLFF dan keberhasilan MLFF jika diterapkan di tol Jabodetabek. Penelitian disusun dengan menggunakan studi literatur dan metode kuantitatif dan perolehan data dilakukan dengan penyebaran kuesioner kepada pengguna jalan tol Jabodetabek. Hasil analisis menunjukkan bahwa mayoritas pengguna jalan tol setuju apabila MLFF diterapkan di Tol Jabodetabek dan berpendapat bahwa dengan diterapkannya MLFF dapat mengurangi kemacetan yang terjadi saat mendekati pintu tol. Namun untuk proses peralihan akan diperlukan sosialisasi yang baik dari pemerintah dan penerimaan masyarakat akan sistem pembayaran baru ini.
ANALISIS PELAYANAN TERHADAP MRT JAKARTA FASE 1 SEBAGAI ACUAN PADA PEMBANGUNAN FASE 2A
Authors: Susanto Nicko 
Published: February 2024

ABSTRACT
Public transportation is one way to reduce Jakarta congestion which is a problem in the capital city. According to INRIX, Indonesia is the number one most congested city in Indonesia and ranks 16th in the world as the most congested city. Mass Rapid Transit is public transportation that can be an alternative to reduce congestion if its users increase and develop. If it continues to be developed and managed properly, the MRT will become the main public transportation that can be used by various groups. To ensure comfort, the government continues to improve good services in order to increase MRT public transportation users. A service system according to spm. Thus public transportation will have adequate minimum service standards so as to satisfy its users. The Phase 1 MRT development project has begun to be completed and is operating with the HI Roundabout - Lebak Bulus route. The government is again trying to increase the construction of the MRT by continuing the development of development to phase 2A, namely the Thamrin - Kota Tua route. Services in phase 1 that are already running will be a benchmark for developing services in phase 2.

Keywords: Mass Rapid Transit, MRT Service Improvement, MRT Development Plan, Phase 1, Phase 2A
ABSTRAK
Transportasi umum adalah salah satu cara guna mengurangi kemacetan Jakarta yang menjadi masalah di Jakarta.Menurut INRIX Indonesia menjadi kota nomor satu termacet di Indonesia dan peringkat 16 di dunia sebagai kota termacet. Mass Rapid Transit adalah transportasi umum yang bisa menjadi alternatif untuk mengurangi kemacetan jika penggunanya semakin meningkat dan berkembang. Apabila terus dikembangkan dan dikelola dengan baik MRT akan menjadi transportasi umum utama yang dapat digunakan berbagai kalangan. Untuk menjamin kenyamanan pemerintah terus meningkatkan pelayanan yang baik guna meningkatkan pengguna transportasi umum MRT. Salah satu upaya yang dibuat adalah menerapkan sistem pelayanan sesuai spm. Dengan demikian transportasi umum akan memiliki standar pelayanan minimum yang memadai sehingga memuaskan penggunanya. Proyek pembangunan MRT Fase 1 sudah mulai selesai dan beroperasi dengan rute Bundaran HI – Lebak Bulus . Pemerintah kembali berupaya meningkatkan pembangunan MRT dengan melanjutkan pengembangan pembangunan ke fase 2A yaitu dengan rute Thamrin – Kota Tua. Pelayanan pada fase 1 yang sudah berjalan akan menjadi tolak ukur untuk mengembangkan pelayanan pada fase 2.
Kata kunci: Mass Rapid Transit, Peningkatan Pelayanan MRT , Rencana Pengembangan MRT , Fase 1 , Fase 2A
STUDI KESELAMATAN DI PERLINTASAN SEBIDANG JPL NO. 5A KM 2 + 285 JALAN HADIAH
Authors: Marsa Rivelieno Rai Marsa , Dewi Linggasari  , Hokbyan R.S. Angkat  
Published: February 2024

AbstractA train is a railroad facility that runs alone or together with other railroad vehicles and can move along the track when the train is running. A railroad crossing is an example of a road and rail meeting, where traffic jams and accidents often occur. In this study the research location was at JPL No. 5a on Jalan Hadiah, Grogol Petamburan, West Jakarta, between Grogol and Pesing stations. This location is one busy intersection. This railroad crossing has a very busy train schedule both on weekdays and weekends. The purpose of this study was to determine the level of safety by assessing the integrity of the signs, the geometry of the crossing, the daily traffic volume, and the characteristics of road users at JPL No. 5a KM2+285. Based on the results of the survey conducted, from the aspect of the completeness of the signs, there are still many that are not yet available and the SMPK obtained is 39.435 smpk, 42.066 smpk, and 40.432 smpk where these results exceed the applicable standards of 3.,000 smpk. The most common types of violations that occur are vehicles waiting in the opposite lane with a probability level of 100% and severity level 3 including the extreme risk categoryAbstrak
Kereta api adalah sarana perkeretaapian yang berjalan sendiri atau bersama dengan sarana perkeretaapian lainnya dan dapat bergerak sepanjang lintasan saat kereta api berjalan. Sebuah perlintasan kereta api adalah contoh pertemuan jalan raya dan kereta api, dimana sering terjadinya kemacetan lalu lintas. Pada penelitian ini lokasi penelitian berada di JPL No. 5a di Jalan Hadiah, Grogol Petamburan, Jakarta Barat, antara stasiun Grogol dan Pesing. Lokasi ini merupakan salah satu perlintasan yang padat. Perlintasan kereta api ini memiliki jadwal kereta api yang sangat padat baik pada hari kerja maupun akhir pekan. Dilakukannya penelitian ini yaitu bertujuan untuk mengetahui tingkat keselamatan dengan menilai keutuhan rambu, geometrik perlintasan, volume lalu lintas harian, dan karakteristik pengguna jalan di JPL No. 5a KM2+285. Berdasarkan hasil survei yang dilakukan, dari aspek kelengkapan rambu, masih banyak yang belum tersedia dan SMPK yang didapat yaitu sebesar 39.435 smpk, 42.066 smpk, dan 40.432 smpk dimana hasil tersebut melebihi standar yang berlaku yaitu sebesar 35.000 smpk. Jenis pelanggaran yang paling sering terjadi yaitu kendaraan menunggu di lajur yang berlawanan arah dengan tingkat probability 100% dan tingkat severity 3 termasuk kategori extreme risk.