bluuebunny/crossref_metadata_2025_split huggingface dataset:
The double-edged sword of statins in intracerebral hemorrhage patients: a systematic review and meta-analysis
Authors: Li Zheng , Xu Wen-qi , Wang Jiao-qi , Yang Jia-hui , Shi Xiao-hua , Wang Cheng-bing , Xu Zhong-xin , Jiang Jin-lan 
Published: January 2025

BackgroundThis meta-analysis aimed to investigate the effect of statins on the prognosis of patients with intracerebral hemorrhage (ICH).MethodsWe conducted a systematic search using the keywords “statin” and “intracerebral hemorrhage” across four electronic databases (PubMed, Cochrane Library, Web of Science, and Embase) from their inception to October 31, 2023, to identify studies comparing the effects of statins on the prognosis of patients with ICH. The primary outcome was total mortality after ICH. This meta-analysis was registered online (PROSPERO ID: CRD42023493063).ResultsOur initial search identified 5,543 studies. After applying inclusion criteria, 30 studies with a total of 42,298 patients were included in the final analysis. Our meta-analysis showed that statins significantly reduced overall mortality in patients with ICH (OR: 0.61; 95% CI: 0.51–0.73; I2 = 87%; p &lt; 0.01). Subgroup analyses further demonstrated lower mortality in ICH patients treated with statins compared to those not treated, including in the propensity score matching (PSM) group (OR: 0.59; 95% CI: 0.48–0.74; I2 = 90%; p &lt; 0.01), the prospective cohort study (PCS) group (OR: 0.56; 95% CI: 0.40–0.77; I2 = 89%, p &lt; 0.01), and the retrospective cohort study (RCS) group (OR: 0.64; 95% CI: 0.51–0.81; I2 = 87%, p &lt; 0.01).ConclusionOur meta-analysis of 30 studies suggests that statin use may be associated with improved mortality and functional outcomes in patients with intracerebral hemorrhage (ICH).Systematic Review Registrationhttps://www.crd.york.ac.uk/PROSPERO/, CRD42023493063.
Joint effect of modifiable risk factors on Parkinson’s disease: a large-scale longitudinal study
Authors: Li Panlong , Zhu Xirui , Liu Min , Wang Yanfeng , Huang Chun , Sun Junwei , Tian Shan , Li Yuna , Qiao Yuan , Yang Junting , Cao Shanshan , Cong Chaohua , Zhao Lei , Su Jingjing , Tian Dandan 
Published: January 2025

IntroductionPrevious researches have often underestimated the diversity and combined effects of risk factors for Parkinson’s disease (PD). This study aimed to identify how multiple modifiable risk factors collectively impact PD.MethodsThe study included 452,492 participants from the UK Biobank, utilizing genetic data and 255 phenotypic variables. A broad exposure association study was conducted across seven domains: socioeconomic status, medical history, psychosocial factors, physical measures, early life, local environment, and lifestyle. Risk scores of each domain for each participant were generated. The joint effects of modifiable and genetic risks assessed using Cox proportional hazards model. Population attributable fraction (PAF) was estimated to quantify contribution ratio of risk factors in different domains to the occurrence of PD.ResultsMultiple risk factors significantly (p &lt; 1.96 × 10−4) associated with PD was observed. The top 5 factors were hand grip strength (hazard ratio (HR) = 0.98, p = 1.59 × 10−24), long-standing illness (HR = 1.38, p = 3.63 × 10−20), self-reported nervousness (HR = 1.56, p = 5.9 × 10−20), ever suffered from mental health concerns (HR = 1.42, p = 5.48 × 10−18) and chest pain (HR = 1.42, p = 1.43 × 10−18). Individuals with unfavorable medical history, psychosocial factors, physical measures, and lifestyle had an increased risk of PD by 33 to 51% compared to those with favorable factors (p &lt; 0.001).DiscussionResults indicated that addressing modifiable risk factors, especially in physical measures and psychological factors, could potentially prevent up to 33.87% of PD cases. In formulating prevention strategies, it is recommended to prioritize domains such as physical measures, psychosocial factors, lifestyle, and medical history.
Screening potential antileukemia ingredients from sweet potato: integration of metabolomics analysis, network pharmacology, and experimental validation
Authors: Xu Lianling , Zeng Kaixuan , Duan Zuoyue , Liu Jing , Zeng Yan , Zhang Miao , Yang You , Guo Qulian , Jin Yanling , Liu Wenjun , Guo Ling 
Published: January 2025

BackgroundActive dietary flavonoids are a promising resource for novel drug discovery. Sweet potato, a widely cultivated functional crop, is abundant in flavonoids. However, the active ingredients associated with acute myeloid leukemia (AML) treatment and their underlying mechanisms have not been reported to date.ObjectiveThis study aims to identify novel drugs against AML from sweet potato by integrating metabolomics analysis, network pharmacology, and experimental validation.MethodsFirstly, ultra-performance liquid chromatography tandem mass spectrometry (UPLC-MS/MS) was employed to analyze the major constituents in sweet potato. Then, nine active ingredients were selected for validation of their anti-leukemia effects. Subsequently, three of them underwent network pharmacology analyses and in vitro experimental verification. Finally, the anti-leukemia effect of cynaroside was further confirmed through in vivo experimental validation.ResultsFirstly, the flavonoid content of stem, leaves, flesh, and peel from 13 sweet potato cultivars was examined. The leaves of Nanshu 017 exhibited the highest flavonoid content of 2.27% dry weight (DW). Then, an extract derived from these leaves was employed for in vitro experiments, demonstrating significant inhibition of AML cell growth. Subsequently, based on the results of metabolomics analysis and network pharmacology, cynaroside, nepitrin, and yuanhuanin were identified as potential antileukemia agents present in sweet potato for the first time; while CASP3, KDR, EGFR, and SRC were recognized as pivotal targets of these three monomers against AML. Finally, the antileukemia effects of cynaroside, nepitrin, and yuanhuanin were confirmed through in vitro and in vivo experimental validation.ConclusionIn summary, sweet potato leaves extract possesses an antileukemic effect while cynaroside, nepitrin, and yuanhuanin demonstrate potential as treatments for AML.
An MRI radiomics model for predicting a prostate-specific antigen response following abiraterone treatment in patients with metastatic castration-resistant prostate cancer
Authors: Wu Yi , Liu Xiang , Chen Shaoxian , Fang Fen , Shi Feng , Xia Yuwei , Yang Zehong , Lin Daiying 
Published: January 2025

ObjectiveTo establish a combined radiomics-clinical model for the early prediction of a prostate-specific antigen(PSA) response in patients with metastatic castration-resistant prostate cancer(mCRPC) after treatment with abiraterone acetate(AA).MethodsThe data of a total of 60 mCRPC patients from two hospitals were retrospectively analyzed and randomized into a training group(n=48) or a validation group(n=12). By extracting features from biparametric MRI, including T2-weighted imaging(T2WI), diffusion-weighted imaging(DWI), and apparent diffusion coefficient(ADC) maps, radiomics features from the training dataset were selected using least absolute shrinkage and selection operator(LASSO) regression. Four predictive models were developed to assess the efficacy of abiraterone in treating patients with mCRPC. The primary outcome variable was the PSA response following AA treatment. The performance of each model was evaluated using the area under the receiver operating characteristic curve(AUC). Univariate and multivariate analyses were performed using Cox regression to identify significant predictors of the efficacy of abiraterone treatment in patients with mCRPC.ResultsThe integrated model was constructed from seven radiomics features extracted from the T2WI, DWI, and ADC sequence images of the training data. This model demonstrated the highest AUC in both the training and validation cohorts, with values of 0.889 (95% CI, 0.764-0.961) and 0.875 (95% CI, 0.564-0.991). The Rad-score served as an independent predictor of the response to abiraterone treatment in patients with mCRPC (HR: 2.21, 95% CI: 1.01-4.44).ConclusionThe biparametric MRI-based radiomics model has the potential to predict the PSA response in patients with mCRPC following abiraterone treatment.Clinical relevance statementThe MRI-based radiomics model could be used to noninvasively identify the AA response in mCRPC patients, which is helpful for early clinical decision-making.
Interaction between arbuscular mycorrhizal fungi and dark septate endophytes in the root systems of Populus euphratica and Haloxylon ammodendron under different drought conditions in Xinjiang, China
Authors: Wang Huimei , Wang Hengfang , Wei Shengtao , Sun Li , Cheng Linlin 
Published: January 2025

Background and AimsArbuscular mycorrhizal fungi (AMF) and dark septate endophytes (DSE) are known to enhance the tolerance of host plants to biotic and abiotic stresses, but the mechanism of their interaction under natural conditions has not been extensively studied.MethodsWe analyzed the endophytic fungal diversity and colonization characteristics in the typical desert plants Populus euphratica and Haloxylon ammodendron and the relationship between them and environmental factors.ResultsExcept for DSE in the roots of H. ammodendron, the colonization rates of AMF and DSE were significantly positively correlated with drought severity. The abundance of AMF and DSE under medium and mild drought conditions was greater than that under severe drought conditions. The root colonization rate and abundance of AMF were lower than those of DSE under the same drought conditions. The species diversity and abundance of AMF and DSE in P. euphratica were greater than those in H. ammodendron. AMF were more susceptible to soil factors such as soil water content, soil nitrogen and phosphorus content, and urease, whereas DSE were more affected by pH.ConclusionDrought stress has different effects on AMF and DSE in the roots of P. euphratica and H. ammodendron. DSE have a greater advantage in extremely arid environments. This study demonstrates the interaction between AMF and DSE with the host plants P. euphratica and H. ammodendron as well as their effects on the adaptation of host plants to the desert environment, which can provide a basis for strengthening desert vegetation management.
Optimizing the role of pharmacists at the primary healthcare centres in Indonesia through an integrated information system
Authors: Yuliasih Nur , Fatinah Yasmin , Abdulah Rizky , Suwantika Auliya A. 
Published: January 2025

IntroductionThe role of pharmacists at primary healthcare centers (PHCs) in Indonesia still needs long-term improvement. Enhancing interprofessional collaboration through data-driven collaboration is essential to strengthening cooperation. This study aimed to identify the need for an integrated information system to enhance the role of pharmacists at PHCs in Indonesia.MethodsA desk review was applied as the initial step to analyze the role of pharmacists at the PHCs in Indonesia. Furthermore, a qualitative study was conducted using Walt and Gilson’s health policy analysis framework. Semi-structured interviews were conducted in four sections (context, content, process, and actors) with consideration of selected key respondents. All interviews were transcribed verbatim and then analyzed using Braun and Clarke’s thematic analyses, ensuring a comprehensive understanding of the situation.ResultsWe identified two significant challenges in optimizing the use of integrated systems at the PHCs to increase the role of pharmacists. Considering context-content-process-actors, implementing integrated pharmaceutical care standards relies significantly on human resources and infrastructures. Key challenges related to human resources are a limited number of human resources, a high workload, and insufficient use of working tools. We found several challenges regarding infrastructure, such as network connectivity issues, non-integrated systems or applications, and suboptimal benefits from the current systems.ConclusionVarious systems or applications in PHC involve reporting to the Ministry of Health, but detailed integration of these systems needs to be achieved immediately. According to informants, the criteria for desired applications are crucial to optimizing the integrated system, using it, and streamlining tasks for pharmacists at PHCs. Common expectations include an integrated system for monitoring drug usage and orders. Apart from usefulness, network connectivity must be assured for accessibility by all parties.
Advancing health equity: evaluating AI translations of kidney donor information for Spanish speakers
Authors: Garcia Valencia Oscar A. , Thongprayoon Charat , Jadlowiec Caroline C. , Mao Shennen A. , Leeaphorn Napat , Budhiraja Pooja , Khoury Nadeen , Pham Justin H. , Craici Iasmina M. , Gonzalez Suarez Maria L. , Cheungpasitporn Wisit 
Published: January 2025

BackgroundHealth equity and access to essential medical information remain significant challenges, especially for the Spanish-speaking Hispanic population, which faces barriers in accessing living kidney donation opportunities. ChatGPT, an AI language model with sophisticated natural language processing capabilities, has been identified as a promising tool for translating critical health information into Spanish. This study aims to assess ChatGPT’s translation efficacy to ensure the information provided is accurate and culturally relevant.MethodsThis study utilized ChatGPT versions 3.5 and 4.0 to translate 27 frequently asked questions (FAQs) from English to Spanish, sourced from Donate Life America’s website. The translated content was reviewed by native Spanish-speaking nephrologists using a standard rubric scale (1–5). The assessment focused on linguistic accuracy and cultural sensitivity, emphasizing retention of the original message, appropriate vocabulary and grammar, and cultural relevance.ResultsThe mean linguistic accuracy scores were 4.89 ± 0.32 for GPT-3.5 and 5.00 ± 0.00 for GPT-4.0 (p = 0.08). The percentage of excellent-quality translations (score = 5) in linguistic accuracy was 89% for GPT-3.5 and 100% for GPT-4.0 (p = 0.24). The mean cultural sensitivity scores were 4.89 ± 0.32 for both GPT-3.5 and GPT-4.0 (p = 1.00). Similarly, excellent-quality translations in cultural sensitivity were achieved in 89% of cases for both versions (p = 1.00).ConclusionChatGPT 4.0 demonstrates strong potential to enhance health equity by improving Spanish-speaking Hispanic patients’ access to LKD information through accurate and culturally sensitive translations. These findings highlight the role of AI in mitigating healthcare disparities and underscore the need for integrating AI-driven tools into healthcare systems. Future efforts should focus on developing accessible platforms and establishing guidelines to maximize AI’s impact on equitable healthcare delivery and patient education.
The long-term outcome of children with VP shunt and hydrocephalus: motor developmental outcome and QOL of patients with hydrocephalus is associated with the number of revisional procedures but is not impacted by the type of the valve
Authors: Wendling-Keim Danielle S. , Luz Hannah , Kren Elena , Muensterer Oliver , Lehner Markus 
Published: January 2025

PurposeDespite constant advances in ventriculo-peritoneal shunt systems, pediatric patients with hydrocephalus may present with neurodevelopmental delay. Therefore, we performed a study including a questionnaire, which aimed to analyze parameters that may have an impact on the cognitive function and quality of life of the pediatric patient with hydrocephalus.MethodsIn this retrospective study, we included 81 patients aged 0–17 with hydrocephalus who were treated with a ventriculo-peritoneal shunt at a single institution. Demographic data, etiology of the hydrocephalus, type of valve implanted, any revision procedures and any complications were analyzed and the neurodevelopmental outcome, epilepsy and quality of life were assessed using a questionnaire sent to these patients. Statistical analysis was performed using SPSS. The significance level was set at p ≤ 0.05.ResultsQuestionnaires were sent to 81 patients who were treated at our institution over a mean retrospective study period of 18 years. Of these, 30 questionnaires were completed by the patients themselves or with the support of their families and included in the study. The etiology of the hydrocephalus as a non-controllable parameter did not affect the cognitive and motor development as well as the occurrence of epilepsy, cephalalgia and the quality of life. However, the number of revisions had a significant (p = 0.041) impact on the motor development of the child. The mean Wellbeing Five score was better with 19.63 in the group with no revisions whereas the score was 12.2 in the group with more than two revisional procedures. The type of the valve (adjustable or not adjustable) as a controllable parameter did not change any of the tested parameters (p &gt; 0.05).ConclusionThe number of revisional procedures significantly affected the motor development of pediatric patients with a ventriculo-peritoneal (VP) shunt calling for further research to improve VP shunt systems as well as surgical procedures like endoscopic third ventriculo-cisternostomy (ETV) in the future.
Effect of Feeding Frequency on the Growth, Body Composition, and Intestinal Health of Hybrid Grouper (Epinephelus fuscoguttatus♀ × E. lanceolatu♂) Fed a High-Fat Diet
Authors: Huang Weibin , Yang Shipei , Cai Wenshan , Huang Wanting , Liu Yansheng , Li Shuaipeng , Zhou Menglong , Tan Beiping , Dong Xiaohui 
Published: January 2025

This experiment was to investigate the effects of feeding frequency on the growth performance, body composition, and intestinal health of hybrid grouper (Epinephelus fuscoguttatus♀ × E. lanceolatu ♂). Fifty-six days of feeding with four different feeding frequencies (1 time/day, 2 times/day, 3 times/day, and 4 times/day) were conducted on groupers with an initial body weight of 11.51 ± 0.02 g. The results show the following: (1) Weight gain rate (WGR) and specific growth rate (SGR) of the groupers in the 1 time/day group were significantly lower than in other groups (p < 0.05). (2) Superoxide dismutase (SOD) had the lowest value in the 1 time/day group, significantly lower than the 2 times/day and 4 times/day groups, catalase showed an upward trend, and the 4 times/day group was significantly greater than the other groups (p < 0.05). The total antioxidant capacity (T-AOC) and glutathione peroxidase (GPX) activities in the 1 time/day group were significantly lower than in the other groups (p < 0.05). (3) The increase in feeding frequency led to a significant increase in the expression levels of cat and il-6 (p < 0.05). In summary, appropriate feeding frequency can promote growth and enhance the antioxidant capacity of the fish’s gut. We recommend a best feeding frequency of 2 times/day.
A Review of the Biological Activity and Structure–Property Relationships of the Main Compounds from Schisandra chinensis
Authors: Skalski Bartosz , Kuźniak Elżbieta , Kowalska Iwona , Sikora Monika , Olas Beata 
Published: January 2025

Schisandra chinensis is a plant from the Schisandraceae family that grows in humid climates, such as forests and mountain slopes. This plant is attracting the attention of an increasing number of scientists around the world, mainly due to its medicinal properties. It contains a variety of bioactive compounds that exhibit significant biological activities, including lignans, flavonoids, phenolic acids, triterpenoids, organic acids and essential oils. This publication is a review of the latest knowledge and research conducted in the field of analysis of biologically active compounds isolated from Schisandra chinensis.
La modélisation 3D, outil de transfert des connaissances Exemple de la réplique de la grotte Chauvet Pont d’Arc : la caverne du Pont d’Arc (Ardèche, France)
Authors: Delannoy Jean-Jacques , Sadier Benjamin , Valcke Serge , Peral José , Perazio Guy , Jaillet Stéphane , Tosello Gilles , Geneste Jean-Michel , Clottes Jean 
Published: January 2025

3D modeling, a tool for the transfer of knowledge from the cave of Chauvet-Pont d’Arc to its replica (Ardeche, France).
Shortly after its discovery in december 1994, several important decisions were taken about the cave of Chauvet-Pont d’Arc (Ardèche) : the priority given to conservation, the commitment by the State on multidisciplinary research, the demand ranking to UNESCO World Heritage and implementation of a facsimile to a broad public to discover the outstanding heritage of this cave. This paper deals with this latter point. It traces the mind and the various stages of implementation of the replica (Cave du Pont-d’Arc, Ardèche). Worn by the local authorities (Ardèche département and Rhone-Alpes région) with the support of the State and Europe, it mobilized a large community of actors (scientists, architects, designers, surveyors, artists, sculptors, modelers...). They have joined forces to restore the spirit of the Cave of Chauvet-Pont d’Arc, with a strong osmosis between the graphical entities and the underground landscapes. From the beginning of the project, it was decided to place the works in their respective environment and to respect the geography of parietal representations. Given the impossibility of restoring the whole cave (8400 m ²), only parts of it were reproduced in the cave, focusing on the major wall panels. The problem was the adjustment of these different parts to recreate a cavity that has the appearance of the real cave and forced it into space of 3000 m ². The 3D tools have been used for the scenic design of the replica, the reconstruction of underground landscapes of the “cave”, mediation with the various businesses who worked that refund and the work of sculptors, modelers and artists who reproduced the cavity and the parietal panels. The paper highlights the different contributions of the 3D tools in the main stages of construction of the largest replica made to date.
La grotte, fruit d’une longue gestation appelée karstification
Authors: Rodet Joël 
Published: January 2025

The cave as the fruit of a large gestation called karstification.
The cave, speleological emblem, results of a very long and complex evolution which can be identified after a concentrated weathering of the substratum. Disconnected at first from the global erosion stages of the landscape, its first definition appears when alteration concentrates in a nucleus. Several stages of transformation of the substratum into an alterite succeed, which finally breaks down, opening an initial free space. Here, water can enter into the potential drain which is shaped once a solution of hydrological continuity is realized, by coalescence of the alteration nuclei transformed in alveoli. This is the birth of the karstic cave which can become a speleological cave, if hydrodynamic events take away a part or the whole of its sedimentary stock. The surface evolution continues to be impacted by weathering and can disconnect the drain, which will fossilize. The evolution of the landscape finally will cut the paleokarst which desappears with the erosion of the relief itself.
Karst libanais et géomatique Application à la réserve naturelle de Arz Jaj (Byblos-Liban)
Authors: Ghanem Diala , Doumit Jean 
Published: January 2025

Geomatics on Lebanese karst, applied research in the Arz Jaj Nature reserve (Byblos).
The karst of the Jurassic bastion of Jabal Jaj is highly developed. The altitude reaches 1959 m and precipitation amounts of 1700 mm per year. Mapping using the classical methods of photokarstology and field visits has given a satisfactory idea of Arz Jaj Nature Reserve karst in conjunction with the existing lithology mainly formed of limestone and dolomites. New geomatics methods, based on high resolution drone imagery, allow the details mapping of karst expressed in closed depressions and inaccessible karst towers.