bluuebunny/crossref_metadata_2025_split huggingface dataset:
Neuronal conversion from glia to replenish the lost neurons
Authors: Liang Shiyu , Zhou Jing , Yu Xiaolin , Lu Shuai , Liu Ruitian 
Published: October 2023

Abstract
Neuronal injury, aging, and cerebrovascular and neurodegenerative diseases such as cerebral infarction, Alzheimer's disease, Parkinson's disease, frontotemporal dementia, amyotrophic lateral sclerosis, and Huntington's disease are characterized by significant neuronal loss. Unfortunately, the neurons of most mammals including humans do not possess the ability to self-regenerate. Replenishment of lost neurons becomes an appealing therapeutic strategy to reverse the disease phenotype. Transplantation of pluripotent neural stem cells can supplement the missing neurons in the brain, but it carries the risk of causing gene mutation, tumorigenesis, severe inflammation, and obstructive hydrocephalus induced by brain edema. Conversion of neural or non-neural lineage cells into functional neurons is a promising strategy for the diseases involving neuron loss, which may overcome the above-mentioned disadvantages of neural stem cell therapy. Thus far, many strategies to transform astrocytes, fibroblasts, microglia, Müller glia, NG2 cells, and other glial cells to mature and functional neurons, or for the conversion between neuronal subtypes have been developed through the regulation of transcription factors, polypyrimidine tract binding protein 1 (PTBP1), and small chemical molecules or are based on a combination of several factors and the location in the central nervous system. However, some recent papers did not obtain expected results, and discrepancies exist. Therefore, in this review, we discuss the history of neuronal transdifferentiation, summarize the strategies for neuronal replenishment and conversion from glia, especially astrocytes, and point out that biosafety, new strategies, and the accurate origin of the truly converted neurons in vivo should be focused upon in future studies. It also arises the attention of replenishing the lost neurons from glia by gene therapies such as up-regulation of some transcription factors or down-regulation of PTBP1 or drug interference therapies.
The bumpy road of purinergic inhibitors to clinical application in immune-mediated diseases
Authors: Wyss Matthias T. , Heuer Christine , Herwerth Marina 
Published: October 2023

Abstract
Purinergic signaling plays important roles throughout the body in the regulation of organ functions during and following the disruption of homeostasis. This is also reflected by the widespread expression of two families of purinergic receptors (P1 and P2) with numerous subtypes. In the last few decades, there has been increasing evidence that purinergic signaling plays an important role in the regulation of immune functions. Mainly, signals mediated by P2 receptors have been shown to contribute to immune system-mediated pathologies. Thus, interference with P2 receptors may be a promising strategy for the modulation of immune responses. Although only a few clinical studies have been conducted in isolated entities with limited success, preclinical work suggests that the use of P2 receptor inhibitors may bear some promise in various autoimmune diseases. Despite the association of P2 receptors with several disorders from this field, the use of P2 receptor antagonists in clinical therapy is still very scarce. In this narrative review, we briefly review the involvement of the purinergic system in immunological responses and clinical studies on the effect of purinergic inhibition on autoimmune processes. We then open the aperture a bit and show some preclinical studies demonstrating a potential effect of purinergic blockade on autoimmune events. Using suramin, a non-specific purinergic inhibitor, as an example, we further show that off-target effects could be responsible for observed effects in immunological settings, which may have interesting implications. Overall, we believe that it is worthwhile to further investigate this hitherto underexplored area.
Evaluating agromorphological traits of Greek wheat landraces and exploring their potential for bread and pasta making based on seed physical properties
Authors: Protonotariou Styliani , Thanopoulos Ricos , Katsileros Anastasios , Bebeli Penelope , Mandala Ioanna 
Published: October 2023

Physical and morphological characteristics of Greek wheat landrace and cultivar seeds were evaluated, aiming to assess their bread- and pasta-making quality. Furthermore, the plant agromorphological traits of wheat landraces and cultivars were measured and correlated with seed physical properties. Fifteen Triticum spp. accessions, out of which four cultivars (two Triticum aestivum and two T. durum), nine landraces (two T. durum, five T. aestivum, one T. dicoccum and one T. polonicum) and two T. durum of unknown status were studied. Seventeen morphological plant and seed traits were measured based on UPOV descriptors. Ear emergence was earlier in cultivars than in landraces. The plant weight of the landraces was, in some cases, almost twice the cultivars’. Seed firmness (62.96–194.85N) was positively correlated with thousand kernel weight and volume (0.840 and 0.791, P < 0.05, respectively). Based on the agromorphological traits, cluster analysis clearly separated the species and the cultivars from the landraces, and the unknown status accessions were grouped with the cultivars. Cluster analysis with all measured traits set the wheat accessions in the following distinct groups: (1) T. durum cultivars including the unknown status accessions, (2) T. aestivum cultivars, and (3) T. aestivum and T. durum landraces. T. polonicum and T. dicoccum each formed a separate group. Seed physical properties of the analyzed Greek landraces indicated their suitability for bread and/or pasta making.
Роль развития мелкой моторики рук в процессе преподавания
русского жестового языка
Authors: Боинчану Галина Ильинична 
Published: October 2023

В настоящее время преподавание русского жестового языка в образовательных организациях высшего образования Министерства внутренних дел России сталкивается с рядом проблем, среди которых одно из первых мест занимает проблема неразвитости мелкой моторики рук взрослых людей, препятствующей усвоению дактильной и жестовой речи как специфических средств общения людей, имеющих проблемы со слухом.
Определение роли развития мелкой моторики рук в процессе преподавания русского жестового языка как многоаспектного и многостороннего механизма воздействия на обучаю-щихся позволит не просто выбрать эффективные методики преподавания, но и решить вопрос о разработке и внедрении педагогической технологии, направленной на формирование коммуни-кативной и инновационной компетенции сотрудников органов внутренних дел России.
Queilitis granulomatosa de Miescher
Authors: Da Rold Julieta , González Silvina , Barrios Paula , Manzur Graciela 
Published: October 2023

La queilitis granulomatosa de Miescher (QGM) es una entidad rara, de curso crónico y pronóstico incierto. Es más frecuente en las mujeres, comienza durante la segunda o tercera década de la vida, y consiste en la aparición de un edema labial recurrente en uno o ambos labios, que se vuelve persistente. Se considera la forma monosintomática u oligosintomática del síndrome de Melkersson-Rosenthal (SMR), cuya tríada se caracteriza por edema labial o facial recurrente, parálisis facial periférica recurrente y lengua plegada. El tratamiento constituye un desafío terapéutico, sin respuesta a corto plazo.
Se presentan 7 casos con diagnóstico de QGM. Se describen la clínica y las opciones terapéuticas.
EVALUASI KEBIJAKAN GREEN ECONOMY DI BANJAR KAYUMAS KELOD DENPASAR BALI
Authors: Ariyanti Ketut Alit 
Published: October 2023

Di Jaman era transformasi 5.0 seperti saat ini kelestarian lingkungan adalah salah satu permasalahan bersama bagi masyarakat di seluruh dunia. Semua negara perlu mengamankan kualitas lingkungan yang cukup untuk jangka pendek dan jangka panjang seperti sumber daya alam, ekosistem, keanekaragaman tanaman dan hewan, termasuk lingkungan hidup manusia. Di era globalisasi kampanye green economy memberikan tekanan pada bisnis yang memberikan dampak kerusakan yang tinggi pada lingkungan. Hal ini juga sampai pada negara-negara berkembang seperti Indonesia, dimana ancaman lingkungan ini memberikan isyarat bagi pemerintahan setempat dan warganya. Metode dalam penelitian ini adalah analisis deskriptif kualitatif. Analisis deskriptif kualitatif ini digunakan untuk memberikan gambaran secara mendalam dan objektif mengenai objek penelitian. Hasil dan pembahasan kebijakan Green Ekonomi di banjar Kayumas Kelod: 1.Program Bank Sampah merupakan konsep pengumpulan sampah kering dan dipilah serta memiliki buku rekening layaknya perbankan. Adapun tujuan dibangunnya bank sampah sebenarnya bukan bank sampah itu sendiri. Bank sampah adalah strategi untuk membangun kepedulian masyarakat terhadap lingkungan dan juga agar dapat 'berkawan' dengan sampah untuk mendapatkan manfaat ekonomi langsung dari sampah 2. Penghijauan, Kegiatan penghijauan. dilakukan untuk menjaga agar kualitas lingkungan hidup tidak semakin terdegradasi dan ini membutuhkan partisipasi aktif masyarakat. Simpulan: Green Economy memiliki tujuan untuk meningkatkan kesejahteraan dan kesetaraan social masyarakat lingkungan dan menerapkan ekonomi hijau terus menerus melakukan trobosan
ANALISIS PEMASARAN USAHA KERIPIK SUKUN “DUA PUTRI” DI DESA BARU KECAMATAN MANGGAR KABUPATEN BELITUNG TIMUR
Authors: Yulia  , Putra Boby Arya 
Published: October 2023

Keripik sukun merupakan salah satu usaha yang cukup diminati. Keripik sukun memiliki cita rasa yang nikmat. Konsumen keripik sukun semakin meningkat seiring meningkatnya variasi rasa dan olahan buah sukun. Tujuan dari penelitian ini yaitu mengetahui saluran pemasaran yang diterapkan pada UMKM “Dua Putri”, merumuskan strategi dan kendala kreasi-pemasaran kreasi keripik sukun. Adapun metode yang digunakan dalam penelitian ini yaitu metode survei. Analisis data menggunakan metode deskriptif kualitatif dengan analisis SWOT. Hasil penelitian menunjukkan bahwa saluran pemasaran yaitu saluran pemasaran nol tingkat dan saluran pemasaran 1 tingkat. Strategi yang dapat diterapkan yakni mempertahankan hubungan antar karyawan, mempertahankan kualitas bahan dasar, mempertahankan kualitas kreasi, meningkatkan SDM guna menghasilkan kreasi berkualitas, menyediakan mesin kasir, meningkatkan citarasa kreasi, menyediakan lebih banyak sarana promosi, menciptakan inovasi kreasi, meningkatkan promosi dan melakukan inovasi dalam pemasaran. Kendala yang dihadapi oleh UMKM “Dua Putri” yaitu kompetisi dalam kreasi yang sama, kompetisi dalam harga, harga dan ketersediaan bahan dasar yang tidak stabil, serta SDM yang rendah.
Nilai Sosial dalam Kumpulan Cerpen Trilogi Alina Karya Seno Gumira Ajidarma dan Rancangan Pembelajaran Bahasa Indonesia di SMA
Authors: Prasetyo Heru , Pertiwi Annisa Diah , Riadi Bambang , Munaris  
Published: October 2023

Abstract:
This study aims to describe the social values ​​of Seno Gumira Ajidarma's short story collection Trilogi Alina and its relation to the design of Indonesian language learning in high school. The method used in this research is descriptive qualitative.The data source of this research is the short story collection Trilogi Alina by Seno Gumira Ajidarma. The data in this study is qualitative data in the form of words, phrases, and sentences in short stories.The data in this study were collected through text content analysis techniques to describe data regarding social values ​​based on Zubaedi's opinion through Charles Sanders Peirce's semiotic approach with index limits. The results of the study show that the collection of short stories Trilogi Alina by Seno Gumira Ajidarma contains social values, namely caring, devotion, helping, loyalty, kinship, values ​​of belonging, discipline, empathy, justice, and cooperation. The results of this study can be used as a learning design for high school.
Penelitian ini bertujuan untuk mendeskripsikan niai-nilai sosial dalam kumpulan cerpen Trilogi Alina karya Seno Gumira Ajidarma dan kaitannya sebagai rancangan pembelajaran Bahasa Indonesia di SMA. Metode yang digunakan dalam penelitian ini, yaitu deskriptif kualitiatif. Sumber data yang digunakan, yaitu kumpulan cerpen Trilogi Alina karya Seno Gumira Ajidarma. Data dalam penelitian ini adalah data kualitatif berupa kata, frasa, maupun kalimat dalam cerpen. Data pada penelitian ini dikumpulkan melalui teknik analisis isi teks untuk mendeskripsikan data-data mengenai nilai-nilai sosial berdasarkan pendapat Zubaedi melalui pendekatan semiotika Charles Sanders Peirce dengan batasan indeks. Hasil penelitian menunjukkan bahwa dalam kumpulan cerpen Trilogi Alina karya Seno Gumira Ajidarma memuat nilai-nilai sosial, yaitu kepedulian, pengabdian, tolong menolong, kesetiaan, kekeluargaan, nilai rasa memiliki, disiplin, empati, keadilan, dan kerja sama. Hasil penelitian ini dapat dimanfaatkan sebagai rancagan pembelajaran untuk kelas XI SMA.
Hepatotoxicidad por tamsulosina / dutasterida: reporte de un caso probable
Authors: Yance Stalin , Montes Pedro 
Published: October 2023

La tamsulosina y dutasterida son medicamentos ampliamente usados como tratamiento de la hipertrofia benigna de próstata. teniendo un buen perfil de seguridad. Existen escasos reportes de injuria hepática asociado al uso de tamsulosina; sin embargo, no hay reportes de toxicidad hepática por el uso de dutasterida y del uso combinado de tamsulosina/dutasterida. Se presenta el caso de un varón de 64 años quien desarrolla injuria hepática tras el uso combinado de tamsulosina/dutasterida, desarrollando un patrón de daño hepatocelular y clínica de hepatitis aguda. Se realizo descarte de patología hepática viral, autoinmune y enfermedades metabólicas de depósito, así como de patología biliar mediante ecografía abdominal y colangioresonancia. En la evaluación de causalidad, presentó CIOMS-RUCAM: 6 puntos (probable) y Naranjo: 4 puntos (posible). El paciente presentó respuesta clínica y laboratorial luego de suspender el medicamento.
Systematic evaluation of the impact of chia seeds on weight loss
Authors: Waruguru Phyllis 
Published: October 2023

This review aims to assess the weight loss effects of chia seeds. Previous studies have documented contradictory findings on chia seeds and their impact on weight loss, hence necessitating a review to clarify this. The primary objective of this study is to evaluate the influence of chia seed consumption on weight loss in individuals participating in Randomised Control Trials. A systematic search was conducted in ClinicalKey, Cochrane, PubMed, Google Scholar, and Hinari. RCTs that investigated the impact of chia seed consumption on weight loss were included in this study, and data on study design, blinding, participant characteristics, chia seed interventions, and placebos were extracted and analysed. Seven studies were analysed. Four documented significant weight loss in the chia seed group when combined with a hypocaloric diet, while two studies indicated minimal weight loss when chia seeds were consumed alongside a normal diet, and one study reported no weight loss among participants on a normal diet and chia seeds supplementation. These findings suggest that chia seed consumption when combined with a hypocaloric diet, can lead to significant weight loss. However, further research with longer intervention periods is necessary to establish the efficacy and optimal dosages of chia seed supplementation for effective weight management. This review, therefore, notes the importance of dietary context in realising the potential benefits of chia seeds in weight loss and highlights the need for more clinical trials in this area.
APPLICATION OF PROBLEM-BASED LEARNING MODEL ON MULTIPLICATION AND DIVISION MATERIAL TO IMPROVE STUDENT LEARNING OUTCOMES IN GRADE III SD NEGERI 4 BANDA ACEH
Authors: Ramli Soleha Puteri Mohamad , Annisa Syaila 
Published: October 2023

Based on observations, one of the problems in SD Negeri 4 Kota Banda Aceh is the low learning outcomes of students in mathematics subjects. The application of the Problem Based Learning model can provide a pleasant atmosphere for students in learning multiplication and division material. This study used the type of Classroom Action Research (PTK). The subjects of this study amounted to 23 students of grade III-B SD Negeri 4 Banda Aceh City, data collection techniques were carried out by observation, documentation, and learning outcomes tests. The technique of analyzing data from observations of student activities is with percentage descriptive statistics and individual student learning outcomes data. Based on the results of research in cycles I, II, and III obtained the following data: (1) the results of observations on student activities in learning observed for three cycles, increased in each cycle, namely: student activity in cycle I reached 82% of the good category, cycle II reached 84% of the good category, and cycle III reached 98% of the very good category. (2) the learning outcomes of students in multiplication and division material increased in cycle I of classical completeness criteria reaching 34% with an average value of 57.39, in cycle II classical completeness criteria of 69% with an average value of 71.37, while cycle III of classical completeness criteria 91% with an average value of 84.34. It was concluded that the Problem Based Learning learning model on multiplication and division material can improve the learning outcomes of grade III-B students of SD Negeri 4 Banda Aceh City.
ASSESSMENT OF THE ANTIFUNGAL ACTIVITY OF Cymbopogan citratus (Lemon grass) LEAF EXTRACT AGAINST SOME PHYTOPATHOGENS
Authors: ORIBHABOR G. O. , IYEKEKPOLOR S. I. 
Published: October 2023

Since the beginning of mankind, nature has been a source of medicinal agent for thousands of years. A plant pathogen is an infectious organism that is capable of causing disease to plants. This research work was aimed at assessing the antifungal activity of Cymbopogan citratus leaf extract on some phytopathogenic fungi isolated from agricultural soils. Aspergillus niger, Aspergillus tamari and Mucor circinelloides were isolated from an agricultural soil. Aspergillus tamari displayed highest susceptibility to the 50% ethanolic extract of the plant with a mycelial radial growth inhibition measurement of 18.25 ± 0.25 mm while Mucor circinelloides displayed the least susceptibility to the 100% ethanolic extract with a mycelial radial growth inhibition of 45.25 ± 0.25 mm. The results were significantly different from the controls (63.25 ± 0.75 mm, Aspergillus niger; 43.25 ± 1.25 mm, Aspergillus tamari and 63.75 ± 0.75 mm, Mucor circinelloides). In the same vein, the aqueous extract also displayed appreciable antifungal activity. The radial growth inhibition of the aqueous extract ranged from 24.25 ± 0.25 mm (25%, Mucor circinelloides) to 34.50 ± 0.50mm (100%, Aspergillus tamari). These were significantly different from the controls. This Study has shown that lemon grass leaf extract possesses antifungal activities to control phytopathogens, from the result obtained, it can be stated that lemon grass can be exploited as an alternative to chemical fungicides in combating resistance amongst phytopathogens.
Session 2: Optimisation
Authors: Stanford Bret , Breuker Roeland De , Krengel Markus Dino , Roussouly Nicolas 
Published: October 2023

**Chair: Prof Laura Mainini, Imperial College**Multi-fidelity optimisation of very flexible composite wing structuresMultidisciplinary design optimisation of actively controlled composite wings is a significant challenge because of the very large design space in terms of design variables and constraints. On the other hand, the computational complexity and time required for the aeroservoelastic analysis of a transport aircraft wing is high. This contradiction between computational time, computational accuracy and the number of required analyses can be solved with multi-fidelity analysis. This type of analysis is traditionally sequential in the design process of an aircraft. We would like to share our views on multi-fidelity analysis in this presentation where will make a case for continuous exchange of information between the various fidelity levels of a given discipline.Potential and limitations within conceptual aircraft design for the optimization of a flexible wing with and without load alleviation.Potential and limitations within conceptual aircraft design for the optimization of a flexible wing with and without load alleviation.Load alleviation is a technology that enhances fuel efficiency of an aircraft by reducing the wing mass. Reducing aerodynamic loads on the transonic, swept outer wing allows for high aspect ratio wings in novel designs. Load alleviation impacts the optimal wing layout and should be considered already in the conceptual design phase.This talk shows a conceptual aircraft design process integrating relevant disciplines through simplified but physics-based models. In particular the flexible wing is integrated. The results of a surrogate based optimization for a long range aircraft with and without load alleviation are shown, the technology potential and limitations within the design space discussed. An outlook on the related work in the UPwing EU-project will be provided, focusing on assessment and optimization of high aspect- ratio, flexible wings for a short-medium range aircraft.Bilevel Multidisciplinary Design Optimization Illustrated on High-Aspect Ratio Strut-Braced WingsBilevel Multidisciplinary Design Optimization Illustrated on High-Aspect Ratio Strut-Braced Wings