bluuebunny/crossref_metadata_2025_split huggingface dataset:
Application of 3D printing-designed split-piece sleeve prosthesis in the revision surgery of tumor-type total elbow prosthetic fractures: a case report
Authors: Zhai Kai , Zheng Kai , Xu Ming , Bao Zhe-ming , Hou Zi-wei , Yu Xiu-chun 
Published: November 2023

Abstract
Objective This study aimed to assess the application of split sleeve technology in the revision surgery of tumor-type total elbow prosthetic fractures.
Case report This retrospective study included a 57-year-old female patient who suffered from left upper arm pain and limited activity for half a month due to trauma. She was admitted to the 960th Hospital of the People’s Liberation Army (Jinan, China) on October 14, 2016. The histopathological type of tumor was hemangioma with active chondroblast proliferation. Following the diagnosis of a bone tumor in the left distal humerus, along with a pathological fracture, customized tumor-type total elbow prosthetic replacement was carried out due to extensive bone destruction in the affected area. After 5 years, she developed left elbow pain and difficulty in flexing the elbow when lifting heavy objects. X-ray showed that the lateral parts of the connection between the left distal humerus and the ulnar prosthesis were displaced. The patient was admitted to the hospital with the diagnosis of prosthetic fracture. Given the absence of bone cement stem loosening in the humeral and ulnar bone marrow, as well as the absence of fractures or osteolysis around the prosthesis, opting for a complete prosthesis revision would result in more substantial bone damage. Hence, the decision was made to retain the original prosthesis. With the assistance of three-dimensional (3D) printing technology, a split-piece sleeve prosthesis at the broken end hinge was designed, and the left distal humeral prosthesis was subsequently revised with a split-piece sleeve total elbow prosthesis at the broken end.
Outcome and Follow-up The surgical process went smoothly, and the prosthesis was accurately installed according to the preoperative design. The patient recovered well after the surgery and the incision was healed in the first stage. During the 2 year follow-up, the elbow split socket prosthesis was firmly fixed without loosening. At the last follow-up, the Mayo Elbow Performance Score (MEPS) was 80 points, and the range of motion of the elbow was 25°～110°.
Conclusion The split sleeve technique possesses the advantages of low surgical difficulty, limited trauma, and definite clinical efficacy in the revision surgery of tumor-type total elbow prosthetic fractures.
Study on Friction and Vibration Characteristics of Brake Disc by Surface Micro-modeling
Authors: Li Chengdong , Jin Jianying , Sun Weihao , Liu Shuang , Tian Xu 
Published: November 2023

Abstract
Aiming at the problem of friction, vibration and noise during braking of disc brakes, the surface of the brake disc is micro-shaped with different densities and different angle distributions, and the finite element model of the disc brake is established. The complex eigenvalue analysis method was used to explore the influence of micro-modeling with different density and angle distribution on the friction and vibration characteristics of disc brakes under different working conditions. The results show that with the increase of braking pressure, the vibration instability of disc brakes increases. The speed of the brake disc has no obvious effect on the vibration stability of the brake; Increasing the elastic modulus of the brake disc will significantly reduce the friction vibration noise of the brake and improve the vibration stability of the brake when braking. The vibration stability of brakes with surface micro-modeling is significantly better than that of the original brakes under different pressure and speed conditions and the elastic modulus of the brake disc, and this paper provides a new idea for the structural optimization of brake vibration and noise reduction.
Sodium selenite ameliorates silver nanoparticles induced vascular endothelial cytotoxic injury by antioxidative properties and suppressing inflammation through activating the Nrf2 signaling pathway
Authors: Ma Yunyun , Wang Lei , He Jing , Ma Xueping , Wang Jingjing , Yan Ru , Ma Wanrui , Ma Huiyan , Liu Yajuan , Sun Hongqian , Zhang Xiaoxia , Jia Shaobin , Wang Hao 
Published: November 2023

Abstract
Silver nanoparticles (AgNP) are the dominant nanomaterials in commercial products and medical field, but the widespread occurrence of AgNP has become a global threat to human health. Growing studies indicate that AgNP exposure can induce vascular endothelial toxicity by excessive oxidative stress and inflammation, which is closely related to cardiovascular disease (CVD), but the potential intrinsic mechanism remains poorly elucidated. Thus, it has been crucial to control the toxicological effects of AgNP in order to improve their safety and increase the outcome of their applications. Multiple researches have demonstrated that sodium selenite (Se) possesses the capability to counteract the toxicity of AgNP. But the functional role of Se in AgNP-induced CVD is largely unexplored. The aim of this study was to explore the potential protective effect of Se on AgNP-induced vascular endothelial lesion and elucidate the underlying mechanisms. An in vivo model of toxicity in animals was established by instillation 200 µL of AgNP into the trachea of rats both with (0.2 mg/kg/day) and without Se treated. In vitro experiments, human umbilical vein endothelial cells (HUVECs) were incubated with AgNP (0.3 µg/mL ) and Se for a duration of 24 h. Utilizing transmission electron microscopy, we observed that internalization of AgNP-induced endothelial cells was desquamated from the internal elastic lamina, the endoplasmic reticulum was dilated and medullary vesicle formed. Se treatment reduced the levels of vascular cell adhesion molecule-1 (VCAM-1) and intercellular adhesion molecule-1 (ICAM-1), inhibited the release of pro-inflammatory cytokines (specifically tumor necrosis factor (TNF)-α, interleukin (IL)-1β and IL-6), improved endothelial cell permeability, integrity and dysfunction, and prevented damage to the aortic endothelium caused by AgNP. Importantly, we found that Se showed the capacity against AgNP with biological functions in guiding the intracellular reactive oxygen species (ROS) scavenging and meanwhile exhibiting anti-inflammation effects. Se supplementation decreased the intracellular ROS release and suppressed NOD-like receptor protein 3 (NLRP3) and nuclear factor kappa-B (NF-κB) mediated inflammation within AgNP intoxicated rats and HUVECs. The anti-oxidant stress and anti-inflammatory effects of Se were at least partly dependent on nuclear factor erythroid 2-related factor 2 (Nrf2). Overall, our results indicated that the protectiveness of Se against AgNP induced vascular endothelial toxicity injury was at least attributed to inhibition of oxidative ROS and pro-inflammatory NF-κB/NLRP3 inflammasome by activating the Nrf2 and antioxidant enzyme (HO-1) signal pathway.
Investigation of main parameters causing decline in water level of Lake Toba during last six decades
Authors: Rosid Mohammad Syamsu , Irwandi Hendri , - Apip , Mart Terry 
Published: November 2023

Abstract
Lake Toba’s water level has declined in the last six decades. Hence, a comprehensive study has been conducted, which is expected to explain the leading causes of Lake Toba's water level decline. The Lake Toba water level discussion is divided into two periods, Period I (1957–1978) and Period II (1981–2020), before and after Siruar Dam’s operation. Climate change and human activities have become significant concerns. Trend tests, quantile mapping bias correction, and water balance were used in this study. The result of the trend test is an increasing trend of rainfall and temperature, while evaporation demonstrates a decreasing trend. In addition, there has been a rising trend in the consumption of lake water for domestic and non-domestic needs, agricultural irrigation, and industrial use. Significant changes in land use have also occurred, especially the decline in dryland forests and an increase in industrial forests, settlements, and dryland agriculture. In Period I, the dominant cause of the water level decrease in Lake Toba was climate. In contrast, the leading cause in Period II was human activities such as the water needs of hydroelectric power plants.
Heavy metals levels in Spinacia oleracea and Daucus carota harvested from soil treated with different amounts of sewage sludge in Pretoria, South Africa
Authors: Mugivhisa Liziwe Lizbeth , Ramaano Thabo , Oladeji Oluwaseun Mary , Olowoyo Joshua Oluwole 
Published: November 2023

Abstract
This study investigated the effects of four different rates of sewage sludge amendment (100, 200, 300, and 400g) on Spinacia oleracea (Leafy vegetable) and Daucus carota (Root vegetable) on the growth and the accumulation of heavy metals. The yield of S. oleracea and D. carota was measured in terms of weight while heavy metals levels at harvest were measured using ICP-MS. The growth and yield at harvest in S.oleracea were in following order 300g > 400g > 200g > 100g while in D.carota the order for the yield was 400g > 200g > 300g > 100g. Elemental concentrations showed that iron (Fe) had the highest average concentration for both plants and ranged between 68.60 ± 2.82mg/kg − 1503.00 ± 82.31mg/kg. Differences obtained as a result of the amendments were significant for heavy metals such as Fe, Pb, Cd from the different plant parts. Concentrations of Pb and Cr recorded in the leaves of S. oleracea were above the recommended limit for human consumption with the exception from leaves of S. Olereacea harvested from soil treated with 400g of sewage sludge. There was no particular trend of heavy metals accumulation noted in the experiment except for the values obtained for trace elements in the roots of D. caraota where, roots parts harvested either from soil treated with 300g or 400g recorded the highest concentrations of these elements. The bioaccumulation factor showed that the elements were bioaccumulated from the soil.
Subretinal injection of anti-vascular endothelial growth factor in the treatment of refractory neovascular age-related macular degeneration
Authors: chen zhiping , wan qi , zou yuling , wu xiaojian , liu rubing , you zhipeng 
Published: November 2023

Abstract
Purpose: To describe the anatomical and visual effects of subretinal injection of anti-vascular endothelial growth factor in the treatment of refractory neovascular age-related macular degeneration.
Methods: Seventeen patients with refractory neovascular age-related macular degeneration were enrolled in a prospective study. All patients were injected with 0.5 mg/0.05 ml conbercept into the macular subretinal area with 41G precision microneedles.
Results: Seventeen patients (9 males and 8 females) with a mean age of 76.24±7.23 years (range 67–91 years) were followed up for a period of twelve months. The best-corrected visual acuity improved from 1.282±0.261 logMAR preoperatively to 1.046±0.255 logMAR 12 months after surgery. The macular retinal thickness decreased from 365.82±89.41 μm before surgery to 179.24±40.92 μm 12 months after surgery. The number of injections ranged from 1 to 3: once in 12 eyes (70.59%), twice in 4 eyes (23.53%), and three times in 1 eye (5.88%). No surgery-related complications were recorded in any of the study eyes.
Conclusions: Subretinal injection of anti-VEGF appears to be an effective treatment for refractory neovascular age-related macular degeneration. However, further studies are needed to analyse prognostic factors affecting functional and anatomic outcomes.
Development of SSR markers in Valeriana clarionifolia Phil. and their transferability to other Valeriana spp
Authors: Manifesto Maria Marcela , Soria Marcelo Abel , Galvan Fatima Veronica , Rivero Alexander Gabriel , Tartara Sabrina Maria Costa , Arizio Carla Marcela , Nagahama Nicolas , Fortunato Renee Hersilia 
Published: November 2023

Abstract
Background:
Several species from valeriana genus are valuable for their medicinal properties. Due to their economic potential, natural populations are threatened by an indiscriminate harvesting. A profitable plan for conservation and rational use must start with accurate identification and genetic diversity evaluation and tools for these purposes need development for valerian species.
In this study, we designed Simple Sequence Repeats (SSR) markers based on transcriptome data for Valeriana clarionifolia Phil. We investigated the polymorphism of these markers and the transferability to five Valeriana species, and we check the applicability in diversity analysis.
Methods and Results:
We designed 691 markers successfully from 2216 putative simple sequence repeat loci. We isolated 11 SSR markers from 60 selected marker loci and tested their polymorphism in V. carnosa Sm., V. clarionifolia Phil, V. gamainensis N. Nagh.,V. moyanoi Speg, V. philippiana Briq. andV. lapatifolia Vahl. The number of alleles per locus ranged from two to eight and the Polymorphism Information Content varied between 0.29 and 0.77. The loci analysed were successfully cross-amplified in the five congeneric species.
Conclusions:
This is the first genomic study in native valerians from Patagonia that can be extended to others worldwide Valeriana species. These tools contribute to the identification, conservation, and material selection. In this way, we can attend a severe problem of sustainability production, environmentally respectful to and product quality. Native medicinal plants could turn out in innovative crops for agriculture diversification and a promising alternative for small regional economies.
Improving Ventilator-Associated Event Surveillance with Dynamic Device-Collected Data
Authors: Graham Laura , Mudumbai Seshadri C. 
Published: November 2023

Abstract
Objective:
To understand the feasibility of automated surveillance, we compared the results of a surveillance algorithm to identify ventilator-associated events (VAE) to the current method of manual chart review and data entry.
Methods and Methods:
This is a retrospective cohort study of patients (n = 654) receiving mechanical ventilation in the hospital ICU between 01/01/2018 and 12/31/2019. A computerized surveillance algorithm was developed and retrospectively. Algorithm-identified ventilator days and VAEs were compared to those reported during the same period for quality improvement.
Results:
The algorithm identified 2,473 ventilator days and 41 VAEs among 39 patients. Quality improvement reports documented a similar number of days (n = 1,776, p = 0.14) and VAEs (n = 24, p = 0.13). Overall, VAE rates per 1,000 ventilator days identified by the algorithm and reported by quality improvement were similar (20.2 vs. 13.5, respectively, p = 0.46)
Discussion:
Algorithm-identified ventilator surveillance measures were no different from those identified by manual review and data entry.
Conclusion:
Triaging VAE surveillance with automated surveillance is feasible and could reduce the time and economic burden of manual chart review.
Association between triglyceride glucose index and heart failure with preserved ejection fraction in patients with coronary heart disease — a RCSCD-TCM study in China
Authors: Li Zhu , Fan Xiang , Liu Yijia , Yu Lu , He Yuanyuan , Li Lin , Gao Shan , Chen Wei , Yang Rongrong , Yu Chunquan 
Published: November 2023

Abstract
Background
The triglyceride glucose (TyG) index serves as a surrogate indicator of insulin resistance. However, there is limited evidence on the association between the TyG index and heart failure with preserved ejection fraction (HFpEF) in patients with coronary heart disease (CHD).
Methods
The 62,794 CHD patients were included used to analyze the relationship between the TyG index and heart failure (HF) in CHD patients. Of these, 8,606 patients who underwent echocardiography were included to identify different types of HF, including HF with reduced ejection fraction (HFrEF), HF with intermediate-range ejection fraction (HFmrEF), and HFpEF. Logistic regression was used to analyze the relationship between the TyG index and HFpEF in CHD patients. The relationship between the TyG index and HFpEF according to sex, age, blood lipids and blood pressure states were also assessed.
Results
A baseline analysis of CHD patients divided into four groups according to the tertile level of the TyG index showed that there were significant differences in related parameters between the groups. In the multi-adjusted modles, the TyG index was significantly associated with the risk of HFpEF (OR: 1.56; 95% CI: 1.08–1.23). In addition, the TyG index of CHD patients was significantly associated with HFpEF in elderly (> 60 years old) patients (OR:1.19; 95% CI: 1.10–1.48), hypertension (OR:1.17; 95% CI: 1.10–1.25) and dyslipidemia (OR:1.16; 95% CI: 1.08–1.23). The association between the TyG index and HFpEF was not affected by sex. And the association between the TyG index of female and HFpEF was (OR:1.21; 95% CI: 1.10–1.34), which was higher than that of male (OR:1.11; 95% CI: 1.02–1.21).
Conclusions
This study demonstrated a significant association of the TyG index and HFpEF in CHD patients. In this study, the results show that the TyG index was independently associated with HFpEF in hypertension, dyslipidemia, and elder patients (> 60 years old). In addition, the association between the TyG index and HFpEF in CHD patients was higher in female.
A new piracy-resistant DNN watermarkingmethod based on secret key and block-wise imagetransformations
Authors: He Shun , Li Chaorong , Wang Xingjie , Zeng Anping 
Published: November 2023

Abstract
In this paper, we propose a new DNN watermarking method that can be usedfor copyright protection of DNN models. This method utilizes learnable blockwiseimage transformation techniques and a secret key to embed watermarkinto a DNN model. Additionally, the method utilizes a black-box watermarkingapproach that does not require a specific predefined training set or triggerset, allowing remote verification of model ownership. Therefore, this method canachieve copyright protection for DNN models by authentication methods for DNNmodels. Experimental results on the CIFAR-10 dataset show that this method ispiracy-resistant and allows the trained DNN models to maintain a high level ofaccuracy in image classification.In addition,the original watermark is not easilyoverwritten by a pirated watermark, showing robustness against fine-tuning andpruning attacks.
Using SHAP to analyze technical and tactical performance in table tennis based on hybrid Catboost-TPE with four-phase evaluation theory
Authors: Song Honglin , Li Yutao , Pan Pengyu , Zhang Zhenhang , Xue Feng , Fu Chenyi , Liu Tianbiao 
Published: November 2023

Abstract

This study adopted a novel algorithm, SHapley Additive exPlanation (SHAP), to analyze the table tennis matches based on a hybrid gradient boosting + categorical features-tree-structured parzen estimator (Catboost-TPE) with the four-phase evaluation theory. 110 singles’ matches (9536 rallies) were analyzed, and 59 elite male players’ winning rates from 2018 to 2022 were categorized into three levels (high, medium, low) by k-means cluster analysis. The results showed that Catboost-TPE has the best performance (MSE = 7.5e-05, MAE = 0.006, RMSE = 0.008, \({\text{R}}^{2}\)=0.99 and adjusted \({\text{R}}^{2}\)=0.989) among six hybrid machine learning algorithms. Using Catboost-TPE to calculate the SHAP value of each feature, the global interpretation and multiple local interpretations found that the performance of receive-attack and serve-attack phases have essential impacts on the winning probabilities in current matches. Besides, this study derived the mathematical equations for converting the scoring rate (SR), usage rate (UR) and technique effectiveness (TE) from the four-phase evaluation theory into the new three-phase evaluation theory to further deepen the theoretical and applied value of the four-phase evaluation theory used in this study. These results provided quantitative references to table tennis matches' characteristics and winning phases. These methods used in the study can be widely applied to other sports performance analyses, and the equations derived in this study are also instructive for relative sports.
Machine learning-based Algorithm Identifies Key Mitochondria-Related Genes in Non-Alcoholic Steatohepatitis
Authors: Dai Longfei , Jiang Renao , Zhan Zhicheng , Zhang Liangliang , Qian Yuyang , Xu Xinjian , Yang Wenqi , Zhang Zhen 
Published: November 2023

Abstract

Background In hepatocytes, mitochondrial dysfunction drives aberrant fatty acid metabolism, oxidative stress, and cell apoptosis, promoting the occurrence and progression of NASH. Given the pivotal role of mitochondrial dysfunction in the advancement of NASH, the identification of mitochondrial core genes within NASH may offer potential targets for NASH treatment. Methods According to 101 machine learning algorithms assembled from 10 different machine learning algorithms, mitochondrial core genes were identified in NASH patients. The relationship between mitochondrial core genes and inflammation, lipid metabolism, liver fibrosis, and immune infiltration was investigated. Results AKR1B10, TYMS, and TREM2 were identified. A predictive model constructed using these three mitochondrial genes exhibited excellent diagnostic performance for NASH in the GEO cohorts. AKR1B10, TYMS, and TREM2 were significantly upregulated in NASH, F3-F4 stage liver fibrosis patients, and NAFLD-HCC patients. The expression levels of AKR1B10, TYMS, and TREM2 were positively correlated with pro-inflammatory genes, lipid synthesis genes, liver fibrosis genes, NAS score, pro-inflammatory immune signatures, and M1 macrophage content. Conversely, they were significantly negatively correlated with fatty acid oxidation genes and M2 macrophage content. Moreover, the biological and mitochondrial pathways enriched when AKR1B10, TYMS, and TREM2 were upregulated were related to NASH progression. NASH patients were further classified into Cluster 1 and Cluster 2. Pro-inflammatory genes, lipid synthesis genes, liver fibrosis genes, NAS score, pro-inflammatory immune signatures, and M1 macrophage content were significantly upregulated in Cluster 1. Conversely, fatty acid oxidation genes and M2 macrophage content were significantly downregulated in Cluster 1. Conclusion AKR1B10, TYMS, and TREM2 are associated with the severity of NASH. High expression of AKR1B10, TYMS, and TREM2 indicates a more severe condition in NASH patients.
WITHDRAWN: Hot Corrosion Evaluation of Cr 3 C 2 /8YSZ based Plasma Sprayed Coatings on SS316 in Na 2 SO 4 – V 2 O 5 Molten Salt Environment at 700 0 C
Authors: Maharajan S , Rex F Michael Thomas 
Published: November 2023

Abstract
Austenitic stainless steel used in power plants and chemical industries is susceptible to corrosion in high-temperature environments. The corrosion is accelerated in high-temperature applications due to chemical substances like sodium, sulphur, and vanadium. The current investigation involves the assessment of the hot corrosion performance of two distinct coatings, namely 8 wt. % Yttria-Stabilized Zirconia (8YSZ) and chromium carbide (Cr3C2), which have been applied using air plasma spraying onto SS316. Coatings were analysed after being heated in the furnace for 50 hours at 7000C at 5 hours/cycle with a salt mixture of Na2SO4 − 60 wt.% of V2O5 (30 mg/cm2). Elemental analysis of the hot corroded specimen was performed using scanning electron microscopy (SEM), X-ray diffraction analysis (XRD) and energy dispersive spectroscopy (EDS). The findings indicate that the 8YSZ coating exhibited enhanced adherence to the substrate for the entire duration of the hot corrosion test. In contrast, it was observed that the Cr3C2 coating underwent total delamination subsequent to the fifth cycle of the hot corrosion test. Bare material shows a substantial degradation surface that peels off without substantial formation of strong surface adherence corrosion products.