bluuebunny/crossref_metadata_2025_split huggingface dataset:
Metabolic Syndrome Is Associated With an Increased Risk of Rheumatoid Arthritis: A Prospective Cohort Study Including 369,065 Participants
Authors: Luo Peiyang , Xu WanLi , Ye Ding , Chen Weiwei , Ying Jiacheng , Liu Bin , Li Jiayu , Sun Xiaohui , He Zhixing , Wen Chengping , Mao Yingying 
Published: January 2024

ObjectiveTo explore the associations between metabolic syndrome (MetS) and its individual components and the risk of rheumatoid arthritis (RA).MethodsA total of 369,065 individuals were included in the present study based on the UK Biobank. Multivariable Cox proportional hazards regression models were applied to estimate the associations between MetS and its individual components and the risk of RA. Mediation analysis was performed to further assess the potential mediating role of C-reactive protein (CRP) in the relationship between MetS and RA.ResultsDuring a median follow-up period of 12.04 years, a total of 4901 incident RA cases were documented. MetS (hazard ratio [HR] 1.22, 95% CI 1.14-1.30) and 4 of its 5 components (elevated waist circumference [WC; HR 1.21, 95% CI 1.12-1.32], elevated triglyceride [TG] level [HR 1.12, 95% CI 1.05-1.19], reduced high-density lipoprotein cholesterol [HDL-C] level [HR 1.31, 95% CI 1.23-1.39], and hyperglycemia [HR 1.15, 95% CI 1.05-1.25]) were associated with an increased risk of RA. In addition, the risk of RA increased as the number of diagnosed MetS components increased, with the highest risk in participants with all 5 components. Mediation analysis showed that CRP might mediate the association between MetS and RA, accounting for 9.27% of the total effect.ConclusionThese findings indicated positive associations between MetS and 4 of its components (WC, TG, HDL-C, and hyperglycemia) and the risk of RA, highlighting the importance of MetS management in the prevention of RA.
Association of Serum Soluble Transferrin Receptor Concentration With Markers of Inflammation: Analysis of 1001 Patients From a Tertiary Rheumatology Center
Authors: Günther Florian , Straub Rainer H. , Hartung Wolfgang , Fleck Martin , Ehrenstein Boris , Schminke Louisa 
Published: January 2024

ObjectiveSoluble transferrin receptor (sTfR) is considered to be a useful biomarker for the diagnosis of iron deficiency, especially in the setting of inflammation, as it is thought to not be affected by inflammation. We analyzed the relationship between sTfR levels and inflammatory markers in patients with known or suspected inflammatory rheumatic disease (IRD).MethodsBlood samples of 1001 patients with known or suspected IRD referred to a tertiary rheumatology center were analyzed. Study participants were classified as patients with active IRD and patients with inactive IRD or without IRD. Correlation analyses were used to explore the relationship between sTfR levels and inflammatory markers (ie, C-reactive protein [CRP], erythrocyte sedimentation rate [ESR]). We applied multiple linear regression analysis to evaluate the predictive value of CRP levels for sTfR concentrations after adjustment for potential confounding factors.ResultsThere were positive correlations between inflammatory markers (CRP, ESR) and serum sTfR levels (ρ 0.44, ρ 0.43, respectively;P< 0.001), exceeding the strength of correlation between inflammatory markers and the acute phase reactant ferritin (ρ 0.30, ρ 0.23, respectively;P< 0.001). Patients with active IRD demonstrated higher serum sTfR levels compared to patients with inactive or without IRD (mean 3.99 [SD 1.69] mg/L vs 3.31 [SD 1.57] mg/L;P< 0.001). After adjustment for potential confounding factors, CRP levels are predictive for serum sTfR concentrations (P< 0.001).ConclusionThe study provides evidence against the concept that sTfR is a biomarker not affected by inflammation.
Patient-Reported Impact of Symptoms in Fibromyalgia (PRISM-FM)
Authors: Weinstein Jennifer , Rosero Spencer , Seabury Jamison , Varma Anika , Engebrecht Charlotte , Khosa Shaweta , Heatwole John , Dilek Nuran , Kaat Aaron , Matallana Lynne Kennedy , Heatwole Chad 
Published: January 2024

ObjectiveTo identify the frequency and relative importance of symptoms experienced by adults with fibromyalgia (FM) and determine factors associated with a higher disease burden.MethodsWe conducted semistructured interviews with 15 participants with FM, collecting 1479 quotes regarding the symptomatic burden of FM. We then performed an international cross-sectional study involving 1085 participants with FM to determine the prevalence and relative importance (scale 0-4) of 149 symptoms representing 14 symptomatic themes. We performed subgroup analysis to determine how age, sex, disease duration, medication use, employment status, change in employment status, missing work due to FM, and ability level are related to symptomatic theme prevalence.ResultsThe symptomatic themes with the highest prevalence in FM were pain (99.8%), muscle tenderness (99.8%), and fatigue (99.3%). The symptomatic themes that had the greatest effect on patients' lives were related to fatigue (2.88), pain (2.85), muscle tenderness (2.79), and impaired sleep and daytime sleepiness (2.70). Symptomatic theme prevalence was most strongly associated with the modified Rankin Scale level of disability, disability status, and change in employment status (on disability vs not on disability).ConclusionParticipants with FM identify a variety of symptoms that significantly affect their daily lives. Many of these symptoms, such as fatigue, sleep disturbance, and activity limitation, are life-altering and not related to traditional diagnostic criteria. Symptom prevalence in this population varies across subgroups based on demographic categories and disability status.
Relationship Between Adalimumab Concentrations, Antidrug Antibodies, and Disease Activity in Rheumatoid Arthritis: A Cross-Sectional Observational Study
Authors: Stamp Lisa K. , Keating Paula , Frampton Christopher , Barclay Murray L. , Fanning Niamh , Millier Melanie , Hessian Paul A. , O’Donnell John L. 
Published: January 2024

ObjectivesTo determine the influence of patient characteristics and disease activity on adalimumab (ADA) concentrations; to assess the relationships between ADA concentrations, the presence of antidrug antibodies (ADAb), and disease activity in rheumatoid arthritis (RA); and to determine the association between cytokine concentrations and ADA concentrations.MethodsA cross-sectional study of people with RA receiving ADA for at least 4 weeks was undertaken. Disease activity was assessed by the Disease Activity Score in 28 joints (DAS28), with responders defined as DAS28 ≤ 3.2. Serum and plasma were obtained for ADA concentrations and ADAb, and a panel of cytokines were obtained for a subgroup. ADA concentrations were compared between demographic and clinical subgroups using ANOVA. The independent associations between clinical and demographic features were analyzed using a general linear model. Variables significantly associated with ADA concentrations from the univariate analyses were entered into multivariate analyses.ResultsOf the 156 participants, 69.2% were female and the mean age was 57.4 (SD 12.7) years. Multivariate analysis revealed that higher C-reactive protein (P< 0.001) and higher weight (P< 0.004) were independently associated with lower ADA concentrations. ADA concentrations were higher in those with DAS28 ≤ 3.2 compared to those with DAS28 > 3.2 (median 10.8 [IQR 6.4-20.8] mg/L vs 7.1 [IQR 1.5-12.6] mg/L,P< 0.001). There was a significant negative correlation between interleukin 6 (IL-6) and ADA concentrations (r= −0.04,P< 0.01).ConclusionADA concentration correlates negatively with markers of inflammatory disease activity in RA, including IL-6. ADA concentration in the range 5 to 7 mg/L over the dose interval are associated with better disease control.
Contribution of Left Ventricular Diastolic Dysfunction to Survival and Breathlessness in Systemic Sclerosis–Associated Interstitial Lung Disease
Authors: Fairley Jessica L. , Hansen Dylan , Burns Andrew , Prior David , La Gerche André , Morrisroe Kathleen , Stevens Wendy , Nikpour Mandana , Ross Laura J. 
Published: January 2024

ObjectiveTo explore the effect of left ventricular (LV) diastolic dysfunction (LVDD) in systemic sclerosis (SSc)-associated interstitial lung disease (ILD), and to investigate SSc-specific associations and clinical correlates of LVDD.MethodsThere were 102 Australian Scleroderma Cohort Study participants with definite SSc and radiographic ILD included. Diastolic function was classified as normal, indeterminate, or abnormal according to 2016 American Society of Echocardiography/European Association of Cardiovascular Imaging guidelines for assessment of LV diastolic function. Associations between clinical features and patient- and physician-reported dyspnea were evaluated using logistic regression. Survival analyses were performed using Kaplan-Meier survival estimates and Cox regression modeling.ResultsLVDD was identified in 26% of participants, whereas 19% had indeterminate and 55% had normal diastolic function. Those with ILD and LVDD had increased mortality (hazard ratio 2.4, 95% CI 1.0-5.7;P= 0.05). After adjusting for age and sex, those with ILD and LVDD were more likely to have severe dyspnea on the Borg Dyspnoea Scale (odds ratio [OR] 2.6, 95% CI 1.0-6.6;P= 0.05) and numerically more likely to record World Health Organization Function Class II or higher dyspnea (OR 4.2, 95% CI 0.9-20.0;P= 0.08). Older age (95% CI 1.0-6.4;P= 0.05), hypertension (OR 5.0, 95% CI 1.8-13.8;P< 0.01), and ischemic heart disease (OR 4.8, 95% CI 1.5-15.7;P< 0.01) were all associated with LVDD, as was proximal muscle atrophy (OR 5.0, 95% CI 1.9-13.6;P< 0.01) and multimorbidity (Charlson Comorbidity Index scores ≥ 4, OR 3.0, 95% CI 1.1-8.7;P= 0.04).ConclusionLVDD in SSc-ILD is more strongly associated with traditional LVDD risk factors than SSc-specific factors. LVDD is associated with worse dyspnea and survival in those with SSc-ILD.
Las manāqib de ʿAbd al-Salām al-Asmar (siglo XV) de Zlīten (Libia). Breve descripción general de la lengua y de los temas
Authors: Mion Giuliano 
Published: January 2024

Las llamadas manāqib (sg. manqaba) son un género literario bastante extendido en los últimos siglos. Algunas de estas manāqib han sido publicadas en ediciones críticas, y su circulación entre los estudiosos suele referirse a la historia norteafricana o a ciertos aspectos de la religiosidad popular. Sin embargo, este tipo de obras ha recibido una atención muy limitada desde el punto de vista lingüístico, a pesar de que presentan características propias de las variedades habladas del árabe. Por lo tanto, las manāqib constituyen una de las pocas fuentes que pueden utilizarse para analizar el árabe hablado y escrito en el pasado.
El objetivo de este artículo es estudiar la lengua de la obra titulada Rawḍat al-azhār wa-munyat al-sādāt al-abrār fī manāqib Sīdī ʿAbd al-Salām al-Asmar, una colección de manāqib relacionadas con el santo sufí libio ʿAbd al-Salām al-Asmar de la ciudad de Zlīten (siglo XV), escrita por Karīm al-Dīn al-Baramūnī al-Miṣrātī.
Dans l’ombre de l’avenir
Authors: Veivo Harri 
Published: January 2024

La Finlande accède à l’indépendance en 1917, sombre aussitôt dans une guerre civile, s’en remet dans la décennie qui suit, goûte à la joie des années folles, traverse ensuite une période de turbulences politiques, et se confronte de nouveau à une guerre, mondiale cette fois, en 1939. Pendant toute cette période, la nouvelle poésie ne cesse de questionner la société, d’interroger le monde moderne qui se crée, de chercher de nouvelles valeurs pour l’avenir. Dans l’ombre de l’avenir raconte l’histoire de la poésie d’avant-garde d’expression finnoise et suédoise de la Finlande dans une période allant de 1916, la date de la publication du premier recueil d’Edith Södergran, la pionnière de la modernité poétique dans le pays, à 1944, la mort de Katri Vala, la poétesse dont l’œuvre cristallisa la lutte entre le nouveau et l’ancien. L’analyse des poèmes est accompagnée d’une étude des groupes d’auteurs et des revues qui ont marqué leur temps, ainsi que d’une contextualisation qui ouvre la voie de la littérature vers les arts, la société et la politique de la Finlande. L’ouvrage est destiné à toute personne qui s’intéresse à l’histoire littéraire et culturelle de la Finlande, à la poésie moderne ou bien aux mouvements d’avant-garde du XXe siècle.
Fabriquer des données, produire du sens : une ethnographie dans les médias
Authors: Burnier Cassandre 
Published: January 2024

À partir de l’approche constitutive de la communication, cet article vise à comprendre comment le sens des données massives est produit dans et par les interactions quotidiennes entre les travailleurs de la donnée et d’autres agents au sein de l’organisation médiatique. Au cours de la réunion observée, une histoire se constitue : la donnée, « le score d’un article », traduit la valeur économique d’un article, l’engagement des lecteurs, puis les performances journalistiques. Cette étude montre comment la donnée, grâce à sa capacité à faire oublier son auteur et à en représenter d’autres en ventriloquant un état de choses quantifié, participe au processus décisionnel et peut être une figure d’autorité, dictant aux journalistes une certaine conduite.
Retour sur un parcours de recherche en éducation relative à l’environnement : Rendre visible la part formatrice de l'autre non humain
Authors: Cottereau Dominique 
Published: January 2024

Depuis 1992, je creuse le sillon de l'écoformation à la fois comme concept de recherche et comme modèle éducatif interventionnel dans le champ de l'éducation relative à l'environnement. Ce numéro de la revue me permet de revisiter ce parcours, d’abord de passage d’enseignante en éducation physique à l’animation de classes de nature (1), puis au travers de trois recherches-actions menées dans le cadre des travaux du Groupe de Recherche en EcoFormation (GREF) : les classes de mer (2)  ; les jardins (3)  ; et les usages de l’électricité dans la vie quotidienne d’un foyer (4). La dernière partie (5) montre qu'une éducation relative à l'environnement intégrant l'écoformation à ses buts et à sa pédagogie est possible, quel que soit le contexte dans lequel elle se déroule, et qui que l'on soit comme éducateur (enseignant, animateur, et même parent). Mais elle nécessite de pousser ou d'abattre des murs, de contourner des contraintes et de rester humble dans l'influence que l'on peut avoir. L'écoformation fut aussi, pour moi, un projet de vie : celui de participer à la transformation éco-sociale des rapports au monde, passant de relations de domination, duelles et agressives avec un vivant objectivé, à des relations de parenté, sensibles, attentives et pacifiées, effaçant le dualisme de l'objet et du sujet entre co-habitants de la planète.
Comparative assessment of nanosized intracanal medicaments on penetration and fracture resistance of root dentin – An in vitro study
Authors: Prashanth BR , Revankar Bhoomika , Karale Rupali , Moogi Prashant P , Mangala MG , Sahoo Amaresh Kumar 
Published: January 2024

Abstract

Context:
The antimicrobial potential of conventional medicaments is reduced due to their limited permeability. The use of calcium hydroxide (CH) is known to reduce the root strength. Nano intracanal medicaments have the following advantages over conventional such as higher surface area and chemical reactivity, and due to its nanosize, have better penetrability, supporting its possible use as an intracanal medicament. Nano versions of CH, chitosan (CS), CS + CH, curcumin (T), and its conventional forms are used in our study.

Aim:
The aim of this study was to evaluate and compare the depth of penetration of nanosized intracanal medicaments and their effect on fracture resistance of root dentin.

Materials and Methods:
Eighty extracted single-rooted teeth were used after decoronation. Canals were enlarged up to size 30 (0.04° taper) using Neoendo instruments (Orikam, India). Teeth were randomly assigned to two broad groups based on the type of intracanal medicament used; Group A: control (conventional) (n = 40) and Group B: nanosized intracanal medicaments (n = 40). Each group was subdivided into four experimental groups (n = 10), Group A1: CH, Group A2: CS, Group A3: curcumin (T), Group A4: CS + CH, Group B1: nano calcium hydroxide (NCH), Group B2: nano CS (NCS), Group B3: nano curcumin (NT), and Group B4: NCS + nano calcium hydroxide (NCS + NCH). All the specimens were stored in a humidor at 37°C for 4 weeks. Out of 10 specimens from each group, five specimens were used for evaluating the depth of penetration using a confocal laser scanning electron microscope, and the remaining five specimens were used for evaluating fracture resistance in a universal testing machine at the end of 4 weeks. Data were analyzed using one-way ANOVA and intergroup comparison using Tukey’s post hoc multiple comparison test.

Results:
The highest fracture resistance was seen with NCS and the maximum depth of penetration with nano calcium hydroxide (NCH).

Conclusion:
The fracture resistance and depth of penetration at a 4-week interval were higher in nano forms compared to their micro-sized counterparts with all groups. The coronal section presented the highest depth of penetration of intracanal medicaments followed by the middle and least in the apical section of root dentin with all groups.
Non-invasive prenatal test (NIPT) for pregnant women (A clinical updated review for a time-bound prospective study)
Authors: Varghese Jinu , Khajuria Atul 
Published: January 2024

ABSTRACT
This article provides an overview of Non-Invasive Prenatal Testing (NIPT), also known as noninvasive prenatal screening. It is a method of determining the risk that the fetus will be born with certain genetic abnormalities for pregnant women. The content is specifically tailored for pregnant women and encompasses a detailed exploration of topics such as Genomics-based noninvasive prenatal tests, sample details for noninvasive prenatal testing, factors influencing test results, the interpretation of test results, limitations associated with the test, and the content included in the Declaration of Consent Form for Noninvasive Prenatal Testing.
Assessment of physiological and psychological dependence of tobacco use among patients visiting the tobacco cessation center in the tertiary institute of Shimla–Himachal Pradesh
Authors: Gurung Deepak , Bhardwaj Vinay Kumar , Fotedar Shailee 
Published: January 2024

ABSTRACT

Background:
The study aimed to assess the physiological and psychological dependence of tobacco use among patients visiting the Tobacco Cessation Center in the tertiary institution.

Methods:
A cross-sectional study design with simple random sampling was used. The information obtained from the subject was through interview recorded on a structured pro forma. The information included demographic details, dependence status based on smoking history and behavior, the Fagerstrom Test for Nicotine Dependence (FTND) for physiological dependence, and the Kano Test for Social Nicotine Dependence (KTSND) for psychological dependence. Tobacco use for both the smoked tobacco (ST) and smokeless tobacco (SLT) was recorded as the number of packs per day.

Results:
The mean pack year score was 122.6 ± 143.8. Similarly, the mean FTND score was 6.8 ± 2.4 and the mean KTSND score was 14.3 ± 4.1. The study subjects in various behavioral stages were precontemplation (26.1%), contemplation (21.1%), preparation (31.4%), action (20%), and maintenance (1.4%), respectively. Simple linear regression shows that the mean pack year, FTND, and KTSND scores were weakly explained for various stages of behavioral changes.

Conclusion:
Pack year is related to dose-response relationship which indicates both intensity and duration for developing tobacco-related diseases. The mean FTND score for physiological nicotine dependence for various variables clearly indicates price inelasticity for tobacco use. The mean KTSND score for psychological nicotine dependence for various variables clearly indicates some price elasticity for tobacco use and socio-behavioral factors related to the pattern of use. Price elasticity is important for the given scale that is used for the type of nicotine dependence considering ST is price inelastic and SLT as price elastic.
Epidemiology of cleft lip and palate: A literature review
Authors: Gupta Abhinav Raj , Ahluwalia Rajiv , Chugh Tina 
Published: January 2024

ABSTRACT
One of the most prevalent birth deformities that cause physical, mental, and social issues for afflicted people and their families is cleft lip and palate (CLP). Its etiology is complicated, and the both environmental and genetic factors may contribute. Risk factors for the development of CLP include Vitamin deficiencies, particularly folic acid deficiencies, and smoking cigarettes, alcohol intake, drug use, and exposure to chemicals. It is critical to understand the causes of CLP to prevent their occurrence and take the appropriate action. This article presents an overall epidemiological aspect of the CLP to provide the literature for the researchers and clinicians working on CLP.
Decoding renal impact: An in-depth study on kidney function in COVID-19 patients at a tertiary care facility
Authors: Sahlot Jyoti , Aggarwal Juhi , Pasha Eram Hussain , Midha Urvashi 
Published: January 2024

ABSTRACT

Background:
The emergence of Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) has marked a pivotal epoch in infectious diseases, surpassing its predecessors in global impact. This study investigates the intricate dynamics of SARS-CoV-2’s impact on renal function, recognizing kidneys as a significant focal point beyond its pulmonary implications.

Aims and Objectives:
The primary aim is to comprehensively assess the renal implications of COVID-19, considering biochemical profiles and complications, particularly in chronic dialysis and kidney transplant recipients. This study aims to delineate the stages of severe COVID-19, emphasizing acute kidney injury (AKI), and explore distinctive clinical considerations surrounding COVID-19’s impact on renal health.

Materials and Methods:
A total of 486 adult patients hospitalized for COVID-19 at Santosh Hospital, Ghaziabad, between May 2020 and June 2021, were enrolled. Stratified into Mild, Moderate, and Severe categories, clinical presentations were analyzed using the One-way Analysis of Variance (ANOVA) test for robust comparisons. Statistical significance, guided by a p-value <0.05, ensured meticulous data interpretation.

Results:
The age distribution revealed varying patterns across severity groups, with notable differences in biochemical parameters. There was a statistically significant difference in urea, creatinine, uric acid, and potassium levels between mild, moderate, and severe cases. Severe patients exhibited higher levels, particularly in urea and creatinine. Gender-wise, males dominated severe cases, underscoring potential risk factors.

Conclusion:
This study unravels the multifaceted impact of COVID-19 on renal function, emphasizing acute kidney injury in severe cases. The elevated risk observed in chronic dialysis patients and kidney transplant recipients highlights the need for vigilant monitoring. Despite unexpected normative electrolyte findings, the study underscores the dynamic and systemic nature of the disease beyond respiratory implications. These insights contribute to a nuanced understanding of COVID-19, urging comprehensive patient assessments and targeted interventions, especially for those with pre-existing kidney conditions. As the world grapples with ongoing waves and emerging variants, continual research into the complexities of COVID-19 remains paramount for clinicians and researchers alike.