bluuebunny/crossref_metadata_2025_split huggingface dataset:
Using Theory of Change to Support Participatory Visual Mapping in Urban Transformation Projects
Authors: Zohar Hadas , Simeone Luca , Morelli Nicola , Martelloni Laura , Marmo Dario 
Published: November 2023

AbstractTheory of Change was created as a logic planning model to explore and represent a potential change in a way that reflects a complex and systemic understanding of development. Even though it is a familiar tool in the context of community initiatives and philanthropic projects, Theory of Change is under‐applied in design as a problem‐solving practice and underexplored within design research. Design projects that are looking for more comprehensive ways of negotiating change can greatly benefit from it to inform a deep understanding of the dynamics of change. This paper focuses on how a designerly approach to Theory of Change can support participatory visual mapping, thus creating some enabling conditions towards transformation in cities, namely: facilitating more granular communication, suggesting a multifaceted and systemic perspective, helping to navigate complexity by creating shared mental models among stakeholders, fostering thinking through different temporalities, and boosting creativity. The paper will examine a case of an urban transformation project that involves six European cities under regeneration.
DNA metabarcoding of light trap samples vs. morphological species identification
Authors: Strutzenberger Patrick , Gottsberger Brigitte , Bodner Florian , Bartusel Fabian , Jerga Daniel , Fiedler Konrad 
Published: November 2023

Abstract
DNA metabarcoding has developed into a commonly used tool for biodiversity assessment and monitoring. How results from DNA metabarcoding are compared with studies based on ‘classic’, in most cases morphological species identification, is still unclear. Studies investigating species detection against a known baseline are virtually non‐existent.
In this study, we used light trap samples collected in eastern Austria to investigate the concordance between morphological species lists and results obtained from COI metabarcoding using the Illumina MiSeq platform. Two primer combinations of different lengths (313 and 205 bp) were compared to assess the influence of amplicon length.
Species detection rates ranged between 0.38 and 0.69; the shorter amplicon had on average higher species detection rates compared with the longer amplicon. Singleton species were less likely to be detected through metabarcoding.
The major determinant for a species to be detected was its biomass, viz. smaller species had a lower chance to be detected. However, there is also evidence of taxonomic bias on the level of superfamilies. While the influence of biomass is to be expected, the presence of taxonomic bias gives reason for concern and requires further studies. Such a bias can be of significance when metabarcoding is used to determine conservation measures. Ordination analyses of all sampling sites showed that as far as community ecology is concerned, the overall pattern obtained from the full species list was mostly preserved in our metabarcoding results.
Combatting ageing in dermal papilla cells and promoting hair follicle regeneration using exosomes from human hair follicle dermal sheath cup cells
Authors: Liu Fang , Liu Si , Luo Xiaohua , Fan Zirui , Huang Shaobin , Deng Fangqi , Liu Huanliang , Shi Ge 
Published: November 2023

AbstractDermal papilla cells (DPCs) undergo premature ageing in androgenetic alopecia and senescent alopecia. As critical components of hair follicle reconstruction, DPCs are also prone to senescence in vitro, resulting in a diminished hair follicle inductivity capacity. Dermal sheath cup cells (DSCCs), a specific subset of hair follicle mesenchymal stem cells, intimately linked to the function of DPCs. The primary objective of this research is to investigate the anti‐ageing effect of exosomes derived from DSCCs (ExoDSCCs) on DPCs. Exosomes were utilized to treat H2O2‐induced DPCs or long‐generation DPCs(P10). Our findings demonstrate that ExoDSCCs(P3) promote the proliferation, viability and migration of senescent DPCs while inhibiting cell apoptosis. The expression of senescence marker SA‐β‐Gal were significantly downregulated in senescent DPCs. When treated with ExoDSCCs(P3), expression of inducibility related markers alkaline phosphatase and Versican were significantly upregulated. Additionally, ExoDSCCs(P3) activated the Wnt/β‐catenin signalling in vitro. In patch assay, ExoDSCCs(P3) significantly promoted hair follicle reconstruction in senescent DPCs. In summary, our work highlights that ExoDSCCs(P3) may restore the biological functions and improve the hair follicle induction ability of senescent DPCs. Therefore, ExoDSCCs(P3) may represent a new strategy for intervening in the ageing process of DPCs, contributing to the prevention of senile alopecia.
A Phase 1 randomized, open‐label clinical trial to evaluate the effect of a far‐infrared emitting patch on local skin perfusion, microcirculation and oxygenation
Authors: van Kraaij Sebastiaan J. W. , Hamblin Michael R. , Pickering Gisele , Giannokopoulos Bill , Kechemir Hayet , Heinz Moritz , Igracki‐Turudic Iva , Yavuz Yalçin , Rissmann Robert , Gal Pim 
Published: November 2023

AbstractFar‐infrared radiation (FIR) has been investigated for reduction of pain and improvement of dermal blood flow. The FIRTECH patch is a medical device designed to re‐emit FIR radiated by the body. This phase 1 study was conducted to evaluate the local effects of the FIRTECH patch on local skin perfusion, microcirculation and oxygenation. This prospective, randomized, open‐label, parallel designed study admitted 20 healthy participants to a medical research facility for treatment for 31 h on three anatomical locations. During treatment, imaging assessments consisting of laser speckle contrast imaging, near‐infrared spectroscopy, side‐stream dark‐field microscopy, multispectral imaging and thermography were conducted regularly on patch‐treated skin and contralateral non‐treated skin. The primary endpoint was baseline perfusion increase during treatment on the upper back. Secondary endpoints included change in baseline perfusion, oxygen consumption and temperature of treated versus untreated areas. The primary endpoint was not statistically significantly different between treated and non‐treated areas. The secondary endpoints baseline perfusion on the forearm (least square means [LSMs] difference 2.63 PU, 95% CI: 0.97, 4.28), oxygen consumption (LSMs difference: 0.42 arbitrary units [AUs], 95% CI: 0.04, 0.81) and skin temperature (LSMs difference 0.35°C, 95% CI: 0.16, 0.6) were statistically significantly higher in treated areas. Adverse events observed during the study were mild and transient. The vascular response to the FIRTECH patch was short‐lived suggesting a non‐thermal vasodilatory effect of the patch. The FIRTECH patch was well tolerated, with mild and transient adverse events observed during the study. These results support the therapeutic potential of FIR in future investigations.
Trichoscopy – a valuable tool for identifying conditions mimicking androgenetic alopecia
Authors: Khutsishvili Nino , Rudnicka Lidia , Ovcharenko Yuliya , Starace Michela , Buchukuri Irma , Pataraia Salome , Lortkipanidze Nino 
Published: November 2023

AbstractAndrogenetic alopecia (AGA) is the most prevalent type of hair loss in women and men. Recently, a European consensus group published guidelines for the diagnostic evaluation of AGA in men, women, and adolescents. This S1 guideline presents expert opinion‐based recommendations for gender‐dependent steps in the diagnostic procedure, which can easily be implemented in the daily clinical routine. For diagnosing AGA, detailed anamnesis and objective learning are not enough because there are several conditions mimicking this disease. Trichoscopy can be considered an important, non‐invasive tool for diagnosing hair and scalp disorders that may have similar clinical signs to AGA.
Contributing to self‐care of a person with chronic obstructive pulmonary disease: A qualitative study of the experiences of family caregivers
Authors: Pendoni Roberta , Albanesi Beatrice , Clari Marco , Pecorari Giulia , Matarese Maria 
Published: November 2023

AbstractAimTo explore family caregivers' experiences of contributing to self‐care of patients with chronic obstructive pulmonary disease (COPD).DesignA qualitative description study.MethodsIndividual semi‐structured interviews were conducted face‐to face, by telephone or video calls in a purposive sample of 17 family caregivers of patients with COPD recruited in Italy, and analysed through content analysis. The consolidated criteria for reporting qualitative studies (COREQ) checklist was used for study reporting.ResultsTen subcategories were derived from 106 codes grouped into three main categories: family caregiver contributions to maintaining disease stable and ensuring a normal life for patients; family caregiver contributions to disease monitoring; and family caregiver contributions to coping with disease exacerbations. Family caregivers provided practical and emotional support, and their contribution was essential to improve treatment adherence, to enable the patient to continue living a normal life, and to have access to the healthcare services. Family caregivers were constantly vigilant and monitored patients daily to detect worsening conditions, and they managed exacerbations especially when patients were unable to do it due to their critical conditions.ConclusionThis study broadens knowledge of family caregivers' contributions to patients' self‐care in COPD, describing the different ways family members provide daily care to patients and the many responsibilities they take on.ImpactFamily caregivers perform a variety of behaviours when supporting patients with COPD in self‐care, especially when patients are more dependent and the disease more severe. Nurses should acknowledge the various contributions provided by family caregivers and develop educational interventions aiming to support them in patient care and improve patient outcomes.Patient or Public ContributionResearchers shared the draft study report with participants for validation and feedback. This helped to strengthen the study design and results.
Unmet care needs of women who have undergone breast cancer surgery: A scoping review
Authors: Ke Qiaohong , Timmins Fiona , Furlong Eileen , Stokes Diarmuid 
Published: November 2023

AbstractAimTo summarize the evidence regarding the unmet care needs of women who have undergone breast cancer surgery and identify research gaps.DesignA scoping review.Data SourcesThis review entailed a systematic search in EMBASE, Medline via PubMed, CINAHL Complete, APA PsycINFO, Cochrane Library, Web of Science and Scopus (up until 30 July 2023).Review MethodsThis review was guided by Arksey and O'Malley's Framework (2005) and the Preferred Reporting Items for Systematic Reviews and Meta‐analysis‐Scoping Review extension (PRISMA‐ScR).ResultsTwenty‐five studies that included 4914 participants were retrieved. Fourteen studies employed quantitative designs, eight used qualitative methods, two were mixed‐methods studies and one used a qualitative meta‐synthesis. Women who have undergone breast cancer surgery experience a wide range of complex and multifaceted unmet care needs. The informational/educational and psychological/emotional domains were the most frequently reported among the identified domains. Meanwhile, the sexual and spiritual/religious beliefs domains remained relatively underexplored. Furthermore, none of the assessment tools used in these studies captured the entirety of the possible domains of unmet care needs.ConclusionNeeds assessment should be integrated into the routine care of women who have undergone breast cancer surgery. Interventions should be developed to address the unmet informational/educational and psychological/emotional needs of women. Future studies should employ high‐quality mixed‐methods approaches to explore women's sexual and spiritual/religious concerns.ImpactThis review provides a comprehensive overview of the unmet care needs of women who have undergone the breast cancer surgery. These findings will contribute to the development of tailored interventions. This review also informs future studies to explore distinct domains of unmet care needs.Patient or Public ContributionNo patient or public contribution.
‘Hearing silences’: Exploring culturally safe transitional care: A qualitative study among Turkish‐speaking migrant frail older adults
Authors: Dolu İlknur , Hayter Mark , Serrant Laura , Lee Amanda 
Published: November 2023

AbstractAimsThis study aimed to investigate the experiences and transitional care needs of Turkish frail older adults living in the UK and determine how this information can be utilized to improve the provision of culturally sensitive care during the transitional period.DesignQualitative descriptive research with semi‐structured individual interviews.Methods“The ‘Silences’ Framework guided the research design, from conceptualizing the research question to structuring the report of final outputs. For this study, semi‐structured, in‐depth interviews were conducted with sixteen older adults living with frailty and five family caregivers between January and May of 2023 in the United Kingdom.ResultsMajor themes that were identified included: (i) information and communication, (ii) care and support, (iii) the role of culture and (iv) trust and satisfaction. Further analysis, through discussion and immersion in the data, revealed that care transition periods were presented alongside three phases of transitional care: pre‐transition (during hospitalization), early‐transition (the period between discharge and the 7th day after discharge) and late transition (the period between the 8th day and 12th month after discharge).ConclusionsOur study revealed that the communication and informational needs of frail older individuals change during the transition period. While Turkish older adults and family caregivers expressed satisfaction with healthcare services in the UK, many struggled due to a lack of knowledge on how to access them.ImpactThe support of family caregivers is a crucial component in facilitating transitional care for frail older patients, as they help in accessing healthcare services and using technological devices or platforms. It should be noted that family caregivers often hold the same level of authority as their elderly Turkish counterparts.Patient or Public ContributionNo patient or public contribution.
Island biogeography of mixed‐species bird flocks: A gregarious nuclear species influences island area effects
Authors: Martínez Ari , Zhou Liping , Si Xingfeng , Ding Ping , Goodale Eben 
Published: November 2023

AbstractAimIsland biogeography theory has been extended to include various species interactions, but has yet to consider intraguild mutualisms. We compare species‐area relationships for mixed‐species flocks to those for the entire bird community and determine how ‘nuclear’ species, those important to flock formation or cohesion, which often have functional traits such as intraspecific gregariousness, influence flock species richness. We hypothesized that mixed flocks would only form on large islands where nuclear species are present. On the subset of larger islands, we expected flock species richness to rise with island area, reflecting a larger pool of species.LocationThirty‐one islands of varying area in the reservoir system of Thousand Island Lake, China.TaxonThe resident forest bird community and its subcomponent of flock participants. Similar to elsewhere in southern China, the primary nuclear species was Huet's Fulvetta (Alcippe hueti), which averaged 20 individuals per flock, and led the flocks when present.MethodsBirds were surveyed in the winter of 2017 and the autumn of 2021.ResultsThe probability for a flock to be present, and the species richness of birds per transect, increased with island area, but the species richness of flocks did not. Flocks with Huet's Fulvetta were only found on islands larger than 30 ha. Flocks on smaller islands formed around secondary nuclear species typical of northern Chinese flocks.Main ConclusionGregariousness as a functional trait may make nuclear species more susceptible to disappearing in small fragments, leading to flock collapse. The extreme gregariousness of fulvettas may also act to increase competition in the flocks they lead and limit the flocks' species richness. We encourage further comparisons of the species‐area curves of mixed‐species flocks and whole bird communities to better understand the influence of flocks on community assembly and species diversity.
A cross‐sectional epidemiological study conducted in Argentina to evaluate the impact of the exposome on skin aging
Authors: Claros Marina Giselle , Lequio Mariana , Cheli Santiago , Garlatti Agustin Bollea , Cecilia Noelia , Juarez Lucrecia , Bittar Mario , Leiva María José , Hernandez Maria Laura , Márquez Juan Manuel , Badaracco Guillermo , Leclerc‐Mercier Stephanie , Leal Maite Iglesias 
Published: November 2023

AbstractBackgroundSkin aging is a gradual cumulative process that may be accelerated by various exposome factors.AimsTo investigate associations between exposome factors and facial skin aging in 11 locations in Argentina.Patients/MethodsAn observational, cross‐sectional study with assessments by exposome questionnaire, Glogau photoaging classification from I to IV, AI‐based algorithm analysis of 7 skin aging signs, and SCINEXA score.ResultsOf 1346 participants, most were women (82%), aged 31–50 years (62%), of skin phototype III (52%), and living in urban areas (94%). The Glogau skin age was higher than the chronological age for 28% of overall participants, 36% of men, and 45% of participants from Ciudad de Buenos Aires versus 12% from Jujuy (p < 0.001).Being male (OR = 1.59; 95% CI 1.18–2.13), exposed to agrochemicals (OR = 1.59: 95% CI 1.01–2.51), of lower socioeconomic levels (OR = 2.06; 95% CI 1.32–3.21) and doing outdoor physical activity (OR = 1.33; 95% CI 1.00–1.76) increased the risk for premature aging. Odds decreased with high daily intake of water (OR = 0.76; 95% CI 0.59–0.97), daily dermocosmetic use (moisturizers [OR = 0.72; 95% CI 0.55–0.94], cleansers [OR = 0.53; CI 95% 0.42–0.67], retinoids [OR = 0.61; 95% CI 0.39–0.95]), and antiaging treatments (OR = 0.74; 95% CI 0.57–0.97).ConclusionsSome exposome factors increased the risk for premature skin aging (physical outdoor activity, exposure to agrochemicals), while others were protective factors (high water intake, antiaging treatments, use of dermocosmetics). Locations with higher pollution levels had more premature skin aging.
LncRNA JHDM1D‐AS1 promotes osteogenic differentiation of periodontal ligament cells by targeting miR‐532‐5p to activate IGF1R signaling
Authors: Zhong Xiaohuan , Wang Huixin 
Published: November 2023

AbstractObjectiveThe aim of this study was to explore the mechanism underlying periodontal ligament cells (PDLCs) osteogenic differentiation.BackgroundPeriodontitis causes damage to tooth‐supporting apparatus and eventually leads to tooth loss. PDLCs hold great promise in periodontal regeneration due to their osteogenic features.MethodsThe expression of osteogenic markers, lncRNA JHDM1D‐AS1, miR‐532‐5p and IGF1R was examined. For osteogenic differentiation, primary human PDLCs (hPDLCs) were cultured in an osteogenic medium, and it was assessed by ALP activity and Alizarin Red staining. The interaction between JHDM1D‐AS1, miR‐532‐5p and IGF1R was analyzed via dual luciferase, RIP and RNA pull‐down assays.ResultsJHDM1D‐AS1 was up‐regulated during osteogenic differentiation and its silencing inhibited hPDLC osteogenic differentiation. JHDM1D‐AS1 worked as a miR‐532‐5p sponge in hPDLCs. miR‐532‐5p directly targeted IGF1R to suppress its expression, and miR‐532‐5p knockdown facilitated osteogenic differentiation of hPDLCs. Overexpression of IGF1R promoted osteogenic differentiation of hPDLCs via activating Notch/HES1 signaling in hPDLCs.ConclusionJHDM1D‐AS1 promotes osteogenic differentiation of hPDLCs via sponging miR‐532‐5p to facilitate IGF1R expression and activate Notch/HES1 signaling.
Post‐training sleep modulates motor adaptation and task‐related beta oscillations
Authors: Ameen Mohamed S. , Petzka Marit , Peigneux Philippe , Hoedlmoser Kerstin 
Published: November 2023

SummaryMotor adaptation reflects the ability of the brain's sensorimotor system to flexibly deal with environmental changes to generate effective motor behaviour. Whether sleep contributes to the consolidation of motor adaptation remains controversial. In this study, we investigated the impact of sleep on motor adaptation and its neurophysiological correlates in a novel motor adaptation task that leverages a highly automatised motor skill, that is, typing. We hypothesised that sleep‐associated memory consolidation would benefit motor adaptation and induce modulations in task‐related beta band (13–30 Hz) activity during adaptation. Healthy young male experts in typing on the regular computer keyboard were trained to type on a vertically mirrored keyboard while brain activity was recorded using electroencephalography. Typing performance was assessed either after a full night of sleep with polysomnography or a similar period of daytime wakefulness. Results showed improved motor adaptation performance after nocturnal sleep but not after daytime wakefulness, and decreased beta power: (a) during mirrored typing as compared with regular typing; and (b) in the post‐sleep versus the pre‐sleep mirrored typing sessions. Furthermore, the slope of the electroencephalography signal, a measure of aperiodic brain activity, decreased during mirrored as compared with regular typing. Changes in the electroencephalography spectral slope from pre‐ to post‐sleep mirrored typing sessions were correlated with changes in task performance. Finally, increased fast sleep spindle density (13–15 Hz) during the night following motor adaptation training was predictive of successful motor adaptation. These findings suggest that post‐training sleep modulates neural activity supporting adaptive motor functions.
Blame it on the “night owls”: Perceived discrimination partly mediates the effects of morningness‐eveningness on positive and negative affect
Authors: Stolarski Maciej , Gorgol Joanna 
Published: November 2023

SummaryThe well‐established effects of evening preference on diminished well‐being and poorer mental health are usually explained in terms of common genetic bases of eveningness and negative emotionality and/or the discrepancy between biological and social clocks, experienced far more frequently by the Evening‐types. However, recent studies provide evidence for the negative stereotyping of evening chronotypes which may lead to unexpectedly pronounced social stigma and its consequences. The present article provides a seminal empirical analysis of the role of perceived chronotype‐related discrimination in the association between morningness‐eveningness and both positive affect and negative affect. The study was conducted on a gender‐balanced sample of 768 individuals aged between 18 and 56 years who filled measures of morningness‐eveningness, positive and negative affect, as well as a modified version of the Perceived Devaluation Discrimination scale, tentatively labeled Perceived Chronotype‐Related Discrimination scale (https://osf.io/urs8x/), developed to measure the sense of chronotype‐based discrimination. Conducted analyses provided evidence for a positive association between eveningness and perceived discrimination. Moreover, perceived discrimination partly mediated the associations between morningness‐eveningness and both positive affect and negative affect, explaining 18% and 29% of these effects, respectively. Hence, our results provide initial evidence for yet another mechanism through which chronotype may impact emotional functioning, namely the experience of chronotype‐based stigmatisation.