bluuebunny/crossref_metadata_2025_split huggingface dataset:
Raman enhancement induced by exciton hybridization in molecules and 2D materials
Authors: Kitadai Hikari , Tan Qishuo , Ping Lu , Ling Xi 
Published: February 2024

AbstractSurface-enhanced Raman spectroscopy (SERS) is a powerful technique for trace-level fingerprinting. Recently, layered two-dimensional (2D) materials have gained significant interest as SERS substrates for providing stable, uniform, and reproducible Raman enhancement with the potential for trace-level detection. Yet, the development of effective 2D SERS substrates is still hindered by the lack of fundamental understanding of the coupling mechanism between target molecules and substrates. Here, we report a systematic excitation-dependent Raman spectroscopy investigation on the coupling between 2D materials such as SnS2, MoS2, WSe2, and graphene and small organic molecules like rhodamine 6G (Rh 6G). Strong coupling between SnS2 and Rh 6G is found due to their degenerate excitons through Raman excitation profiles (REP), leading to the enhancement of Rh 6G vibrational modes that are observable down to 10−13 M. Our study shows that exciton coupling in the substrate-adsorbate complex plays a vital role in the Raman enhancement effect, opening a new route for designing SERS substrates for high sensitivity.
Efferocytosis reprograms the tumor microenvironment to promote pancreatic cancer liver metastasis
Authors: Astuti Yuliana , Raymant Meirion , Quaranta Valeria , Clarke Kim , Abudula Maidinaimu , Smith Olivia , Bellomo Gaia , Chandran-Gorner Vatshala , Nourse Craig , Halloran Christopher , Ghaneh Paula , Palmer Daniel , Jones Robert P. , Campbell Fiona , Pollard Jeffrey W. , Morton Jennifer P. , Mielgo Ainhoa , Schmid Michael C. 
Published: February 2024

AbstractPancreatic ductal adenocarcinoma is a highly metastatic disease and macrophages support liver metastases. Efferocytosis, or engulfment of apoptotic cells by macrophages, is an essential process in tissue homeostasis and wound healing, but its role in metastasis is less well understood. Here, we found that the colonization of the hepatic metastatic site is accompanied by low-grade tissue injury and that efferocytosis-mediated clearance of parenchymal dead cells promotes macrophage reprogramming and liver metastasis. Mechanistically, progranulin expression in macrophages is necessary for efficient efferocytosis by controlling lysosomal acidification via cystic fibrosis transmembrane conductance regulator and the degradation of lysosomal cargo, resulting in LXRα/RXRα-mediated macrophage conversion and upregulation of arginase 1. Pharmacological blockade of efferocytosis or macrophage-specific genetic depletion of progranulin impairs macrophage conversion, improves CD8+ T cell functions, and reduces liver metastasis. Our findings reveal how hard-wired functions of macrophages in tissue repair contribute to liver metastasis and identify potential targets for prevention of pancreatic ductal adenocarcinoma liver metastasis.
Natural language processing of multi-hospital electronic health records for public health surveillance of suicidality
Authors: Bey Romain , Cohen Ariel , Trebossen Vincent , Dura Basile , Geoffroy Pierre-Alexis , Jean Charline , Landman Benjamin , Petit-Jean Thomas , Chatellier Gilles , Sallah Kankoe , Tannier Xavier , Bourmaud Aurelie , Delorme Richard 
Published: February 2024

AbstractThere is an urgent need to monitor the mental health of large populations, especially during crises such as the COVID-19 pandemic, to timely identify the most at-risk subgroups and to design targeted prevention campaigns. We therefore developed and validated surveillance indicators related to suicidality: the monthly number of hospitalisations caused by suicide attempts and the prevalence among them of five known risks factors. They were automatically computed analysing the electronic health records of fifteen university hospitals of the Paris area, France, using natural language processing algorithms based on artificial intelligence. We evaluated the relevance of these indicators conducting a retrospective cohort study. Considering 2,911,920 records contained in a common data warehouse, we tested for changes after the pandemic outbreak in the slope of the monthly number of suicide attempts by conducting an interrupted time-series analysis. We segmented the assessment time in two sub-periods: before (August 1, 2017, to February 29, 2020) and during (March 1, 2020, to June 31, 2022) the COVID-19 pandemic. We detected 14,023 hospitalisations caused by suicide attempts. Their monthly number accelerated after the COVID-19 outbreak with an estimated trend variation reaching 3.7 (95%CI 2.1–5.3), mainly driven by an increase among girls aged 8–17 (trend variation 1.8, 95%CI 1.2–2.5). After the pandemic outbreak, acts of domestic, physical and sexual violence were more often reported (prevalence ratios: 1.3, 95%CI 1.16–1.48; 1.3, 95%CI 1.10–1.64 and 1.7, 95%CI 1.48–1.98), fewer patients died (p = 0.007) and stays were shorter (p < 0.001). Our study demonstrates that textual clinical data collected in multiple hospitals can be jointly analysed to compute timely indicators describing mental health conditions of populations. Our findings also highlight the need to better take into account the violence imposed on women, especially at early ages and in the aftermath of the COVID-19 pandemic.
Targeting the mevalonate or Wnt pathways to overcome CAR T-cell resistance in TP53-mutant AML cells
Authors: Mueller Jan , Schimmer Roman R , Koch Christian , Schneiter Florin , Fullin Jonas , Lysenko Veronika , Pellegrino Christian , Klemm Nancy , Russkamp Norman , Myburgh Renier , Volta Laura , Theocharides Alexandre PA , Kurppa Kari J , Ebert Benjamin L , Schroeder Timm , Manz Markus G , Boettcher Steffen 
Published: February 2024

AbstractTP53-mutant acute myeloid leukemia (AML) and myelodysplastic neoplasms (MDS) are characterized by chemotherapy resistance and represent an unmet clinical need. Chimeric antigen receptor (CAR) T-cells might be a promising therapeutic option for TP53-mutant AML/MDS. However, the impact of TP53 deficiency in AML cells on the efficacy of CAR T-cells is unknown. We here show that CAR T-cells engaging TP53-deficient leukemia cells exhibit a prolonged interaction time, upregulate exhaustion markers, and are inefficient to control AML cell outgrowth in vitro and in vivo compared to TP53 wild-type cells. Transcriptional profiling revealed that the mevalonate pathway is upregulated in TP53-deficient AML cells under CAR T-cell attack, while CAR T-cells engaging TP53-deficient AML cells downregulate the Wnt pathway. In vitro rational targeting of either of these pathways rescues AML cell sensitivity to CAR T-cell-mediated killing. We thus demonstrate that TP53 deficiency confers resistance to CAR T-cell therapy and identify the mevalonate pathway as a therapeutic vulnerability of TP53-deficient AML cells engaged by CAR T-cells, and the Wnt pathway as a promising CAR T-cell therapy-enhancing approach for TP53-deficient AML/MDS.
Réflexions sur la stabilité en section courante des tunnels profonds
Authors: Jassionnesse Christophe 
Published: February 2024

Le présent article traite de la stabilité en section courante circulaire des tunnels profonds. Le massif rocheux étant vu comme un Milieu continu Équivalent, le critère de résistance est le critère de Hoek et Brown généralisé, avec palier de résistance résiduelle. En s’attachant au cas des tunnels profonds, l’introduction de la gravité dans l’équation d’équilibre conduit à rechercher l’existence d’une pression intérieure d’équilibre. L’existence d’une pression de soutènement minimale s’avère un indicateur pertinent du comportement à l’excavation de type « terrain boulant » (severe caving), se traduisant par une instabilité générale de la section non soutenue, tel que défini dans les classifications géomécaniques les plus récentes. Une large étude de variation des paramètres de base du critère de résistance – résistance à la compression et indice de fragilité de la roche, densité et état des discontinuités par le biais du Geological Strength Index –, de la géométrie et de la contrainte in situ supposée isotrope, permet d’identifier la dépendance de cet indicateur aux conditions géologiques. Sur la base de quelques études de cas, il apparaît que les conditions géologiques d’un comportement de type « terrain boulant » correspondent à celles d’un massif de roche tendre, relativement ductile ou fortement altéré et fracturé. Comme ces conditions ne diffèrent pas nettement de celles du « terrain poussant » (squeezing) se traduisant par de fortes convergences, ces deux types de comportement pourraient être les deux degrés d’une même échelle.
Human-Centered Design and Development of a Fall Prevention Exercise App for Older Adults in Primary Care Settings
Authors: Czuber Nichole K. , Garabedian Pamela M. , Rice Hannah , Tejeda Christian J. , Dykes Patricia C. , Latham Nancy K. 
Published: February 2024

Abstract
Background Falls in older adults are a serious public health problem that can lead to reduced quality of life or death. Patients often do not receive fall prevention guidance from primary care providers (PCPs), despite evidence that falls can be prevented. Mobile health technologies may help to address this disparity and promote evidence-based fall prevention.
Objective Our main objective was to use human-centered design to develop a user-friendly, fall prevention exercise app using validated user requirements. The app features evidence-based behavior change strategies and exercise content to support older people initiating and adhering to a progressive fall prevention exercise program.
Methods We organized our multistage, iterative design process into three phases: gathering user requirements, usability evaluation, and refining app features. Our methods include focus groups, usability testing, and subject-matter expert meetings.
Results Focus groups (total n = 6), usability testing (n = 30) including a posttest questionnaire [Health-ITUES score: mean (standard deviation [SD]) = 4.2 (0.9)], and subject-matter expert meetings demonstrate participant satisfaction with the app concept and design. Overall, participants saw value in receiving exercise prescriptions from the app that would be recommended by their PCP and reported satisfaction with the content of the app.
Conclusion This study demonstrates the development, refinement, and usability testing of a fall prevention exercise app and corresponding tools that PCPs may use to prescribe tailored exercise recommendations to their older patients as an evidence-based fall prevention strategy accessible in the context of busy clinical workflows.
Adventures in Coumarin Chemistry
Authors: Langer Peter 
Published: February 2024

AbstractThe cyclization of various nucleophiles, such as 1,3-dicarbonyl compounds, 1,3-bis(silyloxy)-1,3-butadienes, hydrazones, hydroxylamine, amidines, thioglycolic esters, heterocyclic enamines and others, with 4-chlorocoumarins, containing an electron-withdrawing group at position 3, allows for a convenient synthesis of a great variety of benzo[c]coumarins and related fused coumarins. Suzuki–Miyaura reactions of coumarin-derived bis(triflates) result in formation of arylated coumarins with excellent regioselectivity that is controlled by electronic and steric features of the substrate. The combination of Suzuki–Miyaura with lactonization reactions of carba- and heterocyclic substrates allows for the synthesis of benzo[c]coumarins and of other fused coumarins. Domino Michael–retro-Michael–lactonization reactions of 1,3-bis(silyloxy)-1,3-butadienes with chromones provide a convenient access to hydroxylated benzo[c]coumarins. In a related approach, fused coumarins were prepared by domino reactions of heterocyclic enamines with chromone-3-carboxylic acids.1	Introduction2	Reactions of 3-Acceptor-4-chlorocoumarins3	Reactions of Coumarin Triflates4	Synthesis of Fused Coumarins5	Conclusions
Hybrid organizations: a classification within economic sectors
Authors: Pilon Marc , Mansurov Alisher 
Published: February 2024

AbstractCommonly identified economic sectors include the private, public, and nonprofit sectors. However, many types of organizations overlap, exhibiting characteristics of hybridity between different economic sectors. Hence, classifying organizations that display these overlapping characteristics creates confusion. Considering this confusion, this interdisciplinary study aims to develop a more complete conceptual model of economic sectors that integrates hybridity. This article does so by integrating the institutional logics of ownership and funding to categorize the different types of hybrid organizations, while using the Canadian context to anchor the study. The developed typology is useful as it positions hybrid organizations along economic sector lines.
Pretending to pretend
Authors: Virtanen Tuija 
Published: February 2024

Abstract
This chapter explores virtual performances of “autohypocrisy”, an overt form of pretence where users
instantaneously and simultaneously execute and expose their own hypocritical act. Examining conventionalizing and
creative uses on Twitter of the self-referential third-person performative predication *pretends to be shocked*,
corresponding propositional hashtags and performative “not-selfie” GIFs, the study discloses the layers of
performativity involved and discusses self-presentational aspects of their public sharing. Paradoxically, virtually
exposing one’s own pretence of being shocked may benefit self-promotion by giving the impression of the user being a
sincere person, genuine and likeable. As a “benign” form of hypocrisy, playful performances of autohypocrisy allow
users to avoid excesses of self-righteousness and provide them with ways of preserving the dignity of their online
personhood.
A plea for hypocrisy
Authors: Sorlin Sandrine 
Published: February 2024

Abstract
This chapter shows to what extent hypocrisy is more ubiquitous and essential than one may think. There are
however degrees of hypocrisy that I highlight by elaborating a continuum of the phenomenon that ranges from insincere
politeness to deliberate deception. Politics being one of the fields where hypocrisy has been shown to be inevitable,
I use the satirical political TV series Veep (HBO 2012–2019) to illustrate what I propose as a
“Hypocrisy Principle”. This principle comprises several maxims which consist of flattering and (dis)simulating, each
using different forms of language and being the preserve of a certain type of hypocrites. I develop the notion of
‘civil hypocrisy’ for the lighter side of the phenomenon. The darker socially unacceptable side involves the notions
of duplicity and simulation that can go all the way towards self-deception.
Controlling phase transitions in MnNiGe using thermal quenching and hydrostatic pressure
Authors: Chen Jing-Han , Poudel Chhetri Tej , Grant Anthony T , Bai Xiaojian , Zhang Qiang , Chang Chung-Kai , Young David P , Dubenko Igor , Talapatra Saikat , Ali Naushad , Stadler Shane 
Published: February 2024

Abstract
The phase transitions in MnNiGe compounds were explored by manipulating the heat treatment conditions and through hydrostatic pressure application. As the quenching temperature increased, both the first-order martensitic structural transition temperatures and magnetic transition temperatures decreased relative to those in the slowly-cooled samples. When the samples were quenched from 1200 ∘C, the first-order martensitic structural transition temperature lowered by more than 200 K. The structural transitions also shifted to lower temperature with the application of hydrostatic pressure during measurement. Temperature-dependent x-ray diffraction results reveal that the changes of the cell parameters resulting from the structural transitions are nearly identical for all samples regardless of the extensive variation in their structural transition temperatures. In addition, neutron scattering measurements confirm the magnetic structure transition between simple and cycloidal spiral magnetic structures.
Experiments at the edge of space: balloon flights to the stratosphere
Authors: Denton M H , Blum L , Kivi R , Bruce S , Ramos P , Feinland M , Ulich T , Denton J J 
Published: February 2024

Abstract
Over 1500 balloons are launched every day, from every continent on Earth, to provide forecasting of tropospheric weather. Similar balloons, which can fly to the edge of space (>30 km), can be used for other science projects. Professional scientists, military users, commercial organisations, and interested amateurs, all fly payloads that provide a relatively low-cost means to reach the upper atmosphere. Weather ballooning is perfectly suited to student education and has been carried out for decades by groups of school, college, and university students. Here we report on one such a project. During March/April 2023 a series of balloons were launched from Sodankylä, Finland, in order to study the particle and radiation environment, along with ozone, in the stratosphere. Inexpensive off-the-shelf Geiger-counters were part of a payload flown to investigate how the radiation environment changed over time. Balloon payloads can be tracked with simple and inexpensive radio receivers. Similar projects to the one outlined here should be possible for any school, college, or university that has a reasonably well-equipped workshop, a group of interested and capable students, and a desire to investigate and learn something new about the planet we live on.
Investigating magnetization of permanent magnets by magnetic flux viewing film
Authors: Erhart Jiří , Hejsková Pavlína 
Published: February 2024

Abstract
Permanent magnets are used in many current industrial as well as home appliances today. Frequently, kitchen plastic magnets could be found at the refrigerators at home. However, the magnetic domain structure of such permanent plastic foils is not known and understood to the users at all. The purpose of this paper is to explain the magnetic domain structure of plastic magnets with Halbach array and ferrite or neodymium magnet polarization orientation. Principles of magnetic field visualization foils (magnetic flux detector and colour changing viewing film) is explained and demonstrated on multipole magnetic structures. Experiments with magnetic polarization reversal by the strong neodymium magnet in weaker ferrite magnetic material is demonstrated. All presented principles are collected in the simple magnetic set and suggested for education of school children of different ages. Elementary school children below 10 years age are mostly interested only in making hidden pictures in magnetic paper and ferrite magnet. Older school children of 11–12 years are able to absorb more knowledge about behaviour and properties of magnets.
Demonstration of conservation of momentum using Lato Lato 2.0
Authors: Wibowo Edy , Ulya Naily , Marwoto Putut 
Published: February 2024

Abstract
In this work, the second generation of Lato Lato (Lato Lato 2.0) has been used to demonstrate the concept of conservation of momentum. The Lato Lato 2.0 toys are two identical solid balls that are attached to the stick handle via a stick. The balls are meant to rotate in response to the movements of the stick handle. With the assistance of these toys, the concepts of action-reaction forces, two objects colliding, and conservation of momentum are easily understood. As an alternative to commonly used apparatus such as the Newton Cradle, these inexpensive toys can undoubtedly elucidate the concepts of conservation of momentum. Therefore, the Lato Lato 2.0 can be used for pedagogical purposes in learning physics. Indeed, physics is more enjoyable to learn and easier to understand through demonstrations.
QScatter: numerical framework for fast prediction of particle distributions in electron-laser scattering
Authors: Amaro Óscar , Vranic Marija 
Published: February 2024

Abstract
The new generation of multi-PetaWatt laser facilities will allow tests of strong field quantum electrodynamics (QED), as well as provide an opportunity for novel photon and lepton sources. The first experiments are planned to study the (nearly) head-on scattering of intense, focused laser pulses with either relativistic electron beams or high-energy photon sources. In this work, we present a numerical framework that can provide fast predictions of the asymptotic particle and photon distributions after the scattering. The method detailed in this manuscript can include multiple features such as spatial and temporal misalignment between the laser and the scattering beam, broadband electron beams, and beam divergence. The expected mean energy, energy spread, divergence or other observables are calculated by combining an analytical description and numerical integration. This method can provide results within minutes on a personal computer, which would otherwise require full-scale 3D QED-PIC simulations using thousands of cores. The model, which has been compiled into an open-source code QScatter, may be used to support the analysis of large-size data sets from high-repetition rate experiments, leveraging its speed for optimization or reconstruction of experimental parameters.
Training-free performance of the wax-impregnated SuShi septum magnet
Authors: Barna D , Brunner K , Novák M , Borburgh J , Atanasov M , Lackner F , Olvegård M , Pepitone K , Santiago Kern R , Svanberg C , Bagni T 
Published: February 2024

Abstract
In the framework of the Future Circular Collider Study a new septum magnet concept, nicknamed ‘SuShi’ has been developed, and a prototype was built at Wigner Research Center for Physics, and tested at the FREIA facility of Uppsala University in April 2023. The concept uses a canted cosine theta (CCT)-like superconducting magnet and a passive superconducting shield to create a zero-field and high-field region within its aperture. SuShi is the first CCT magnet with both of its winding layers simultaneously impregnated with wax. This paper describes the first powering test of the empty magnet at 4.2 K, without the shield being inserted in its aperture. The performance of the magnet, including the observation of quench-back, estimation of hot-spot temperatures and the fraction of energy dissipated in the magnet are presented, and most interestingly the absence of any quench during the entire testing period is reported. Sushi reached its nominal +5% peak field of 3.64 T at 450 A, which corresponds to 80% of the calculated short sample limit along the load line, without training.