bluuebunny/crossref_metadata_2025_split huggingface dataset:
THE ASSOCIATION OF AIR POLLUTION AND CLIMATE FACTORS WITH DEPRESSIVE SYMPTOMS AMONG OLDER MEXICAN AMERICAN ADULTS
Authors: Saab Diane , Cantu Phillip , Downer Brian , Markides Kyriakos , Milani Sadaf 
Published: December 2023

Abstract
Air pollution, drought, and extreme heat are associated with elevated depressive symptoms. Older Mexican American adults experience high levels of depressive symptoms compared to other demographic groups, but little is known about the role of environmental factors in depressive symptoms for this population. Mexican American adults are resilient to the harmful health effects of socioeconomic disadvantage, but it is unclear if this resilience extends to air pollution and climate change. This study uses data from the Hispanic Established Populations for the Epidemiologic Study of the Elderly (H-EPESE) linked to air pollution and climate data from the Centers for Disease Control and Prevention, to assess the association of air pollution (PM2.5 and ozone) and climate factors (drought and extreme heat) with elevated depressive symptoms. We used data from the 2005 H-EPESE which includes Mexican American adults aged 75 and older. We used generalized estimation equations to test the association between air pollution and climate factors and depressive symptoms, adjusting for sociodemographic and health characteristics. Our sample (n=1,699) was 62.0% female with a mean age of 81.6 (standard deviation: 5.0). About 19% of participants reported elevated depressive symptoms. PM2.5 concentration was associated with higher odds of depressive symptoms (odds ratio: 1.11; 95% confidence interval: 1.04, 1.19). Ozone concentration, drought, and extreme heat were not associated with depressive symptoms. Our results suggest PM2.5 is a risk factor for elevated depressive symptoms. It is unclear if older Mexican American adults are resilient to the effects of environmental risk factors relative to other demographic groups.
A MECHANISM OF ACTION OF HUMAN-ORIGIN PROBIOTIC COCKTAIL IN ATTENUATING ALZHEIMER’S DISEASE PATHOLOGY
Authors: Prajapati Santosh Kumar , Wang Shaohua , Mishra Sidharth , Jain Shalini , Yadav Hariom 
Published: December 2023

Abstract
Alzheimer’s disease (AD) is a detrimental public health problem affecting millions of older adults in the USA alone, with no or limited treatment options. Emerging evidence indicates the pivotal role of gut microbiota in AD pathology, but mechanisms remain largely unknown. Also, microbiome modulators like probiotics are proven beneficial in preventing AD with little understanding of their mechanisms. Therefore, we investigated how a microbiota metabolite-short-chain free fatty acid receptor-2 (FFAR2) signaling in the intestine affects AD pathology in brain using intestinal FFAR2 knock-out APP/PS-1 mice; as well as determined if a human-origin-probiotic cocktail exhibits its actions via FFAR2 signaling. We measured changes in the microbiome, permeability in gut and blood-brain barriers (BBB), neuroinflammation, AD pathology, and cognitive behaviors. Results showed, the mice lacking FFAR2 in their intestine exacerbated AD pathology by developing abnormal changes in gut microbiome and intestinal permeability, which in turn promotes permeability in BBB and neuroinflammation. It’s also promoting microglia activation linked with increased Aβ accumulation and cognitive decline. It’s interesting to note that probiotic cocktail feeding reversed these abnormalities in AD mouse models. Further, this probiotic cocktail showed its mechanism in both FFAR2-dependent and independent manner. Overall, our findings indicate that the microbiome sensing mechanism FFAR2 signaling participates in regulating the gut-brain in AD pathology, and a human-origin probiotic cocktail improves the abnormal changes in the microbiome-intestinal & BBB permeability-neuroinflammation axis to ameliorate AD pathology. Thus, FFAR2 agonism and probiotic therapy can be viable options to prevent/ delay the risk of AD progression in older adults.
Evaluating the Dyadic Benefits of Early-Phase Behavioral Interventions: An Exemplar Using Data From Couples Living With Parkinson’s Disease
Authors: Lyons Karen S , Russell Luke T , Bonds Johnson Kalisha , Brewster Glenna S , Carter Julie H , Miller Lyndsey M 
Published: December 2023

Abstract

Background and Objectives
There are a growing number of early-phase (i.e., Stage I, NIH Stage Model) interventions targeted at family care dyads navigating chronic health conditions in older adults. Currently, the benefits of these interventions are often evaluated for older adults and their family care partners separately, even when controlling for interdependence. Without understanding the benefits (and potential harms) for dyads as a whole, understanding of program impact is incomplete. Moreover, few health behavior interventions involving dyads include relational measures to ensure no unintended consequences for the dyad or account for within-dyad pretest risk level.

Research Design and Methods
We used secondary data from a quasi-experimental trial involving 39 couples in which 1 member of the dyad was living with Parkinson’s disease as an exemplar demonstration of 3 proposed approaches: an above-zero approach, a pretest risk status approach, and an expanded pattern analysis matrix approach.

Results
Approaches provided evidence for dyadic benefits of the intervention compared to the wait-list comparison condition, but carried different assumptions that did not always categorize dyads similarly.

Discussion and Implications
Implications of using each approach and selecting different benchmarks for defining success are discussed. The descriptive approaches proposed, provide a rationale for more intentional evaluation of small-sample, early-phase dyadic interventions.
Rigidity, Tensegrity, and Reconstruction of Polytopes Under Metric Constraints
Authors: Winter Martin 
Published: December 2023

Abstract
We conjecture that a convex polytope is uniquely determined up to isometry by its edge-graph, edge lengths and the collection of distances of its vertices to some arbitrary interior point, across all dimensions and all combinatorial types. We conjecture even stronger that for two polytopes $P\subset {\mathbb {R}}^{d}$ and $Q\subset {\mathbb {R}}^{e}$ with the same edge-graph it is not possible that $Q$ has longer edges than $P$ while also having smaller vertex-point distances. We develop techniques to attack these questions and we verify them in three relevant special cases: $P$ and $Q$ are centrally symmetric, $Q$ is a slight perturbation of $P$, and $P$ and $Q$ are combinatorially equivalent. In the first two cases the statements stay true if we replace $Q$ by some graph embedding $q:V(G_{P})\to {\mathbb {R}}^{e}$ of the edge-graph $G_{P}$ of $P$, which can be interpreted as local resp. universal rigidity of certain tensegrity frameworks. We also establish that a polytope is uniquely determined up to affine equivalence by its edge-graph, edge lengths and the Wachspress coordinates of an arbitrary interior point. We close with a broad overview of related and subsequent questions.
Concomitant Administration of Ad26.RSV.preF/RSV preF Protein Vaccine and High-Dose Influenza Vaccine in Adults 65 Years and Older: A Noninferiority Trial
Authors: Widagdo Widagdo , Bastian Arangassery Rosemary , Jastorff Archana M , Scheys Ilse , De Paepe Els , Comeaux Christy A , Ligtenberg Nynke , Callendret Benoit , Heijnen Esther 
Published: December 2023

Abstract

Background
Since influenza and respiratory syncytial virus (RSV) carry significant burden in older adults with overlapping seasonality, vaccines for both pathogens would ideally be coadministered in this population. Here we evaluate the immunogenicity and safety of concomitant administration of Ad26.RSV.preF/RSV preF protein and high-dose seasonal influenza vaccine (Fluzone-HD) in adults ≥65 years old.

Methods
Participants were randomized 1:1 to the Coadministration or Control group. The Coadministration group received concomitant Ad26.RSV.preF/RSV preF protein and Fluzone-HD on day 1 and placebo on day 29, while the Control group received Fluzone-HD and placebo on day 1 and Ad26.RSV.preF/RSV preF protein on day 29. Influenza hemagglutination-inhibiting and RSV preF–binding antibody titers were measured postvaccination and tested for noninferiority between both groups. Safety data were collected throughout the study and analyzed descriptively.

Results
Coadministered Ad26.RSV.preF/RSV preF protein and Fluzone-HD vaccines induced noninferior immune responses compared to each vaccine administered alone. Seroconversion and seroprotection rates against influenza were similar between groups. Both vaccines remained well tolerated upon concomitant administration.

Conclusions
Coadministration of Ad26.RSV.preF/RSV preF protein and Fluzone-HD showed an acceptable safety profile and did not hamper the immunogenicity of either vaccine, thus supporting that both vaccines can be concomitantly administered in adults ≥65 years old.
Episodic Cost of Lower Respiratory Tract Illness due to Respiratory Syncytial Virus Among US Infants During the First Year of Life
Authors: Averin Ahuva , Law Amy , Shea Kimberly , Atwood Mark , Munjal Iona , Weycker Derek 
Published: December 2023

Abstract
A study of 2 health care claims databases (commercial, Medicaid) was undertaken to estimate the episodic cost of lower respiratory tract illness due to respiratory syncytial virus among infants aged &lt;12 months overall, by age, and by birth gestational age. Among commercial-insured infants, mean costs were $28 812 for hospitalized episodes, $2575 for emergency department episodes, and $336 for outpatient clinic episodes. Costs were highest among infants aged &lt;1 month and infants with a gestational age ≤32 weeks and were comparable among Medicaid-insured infants, albeit somewhat lower. The cost of lower respiratory tract illness due to respiratory syncytial virus during the acute phase of illness is high, especially among the youngest infants and those born premature.
Metatranscriptomic data mining together with microfluidic card uncovered the potential pathogens and seasonal RNA viral ecology in a drinking water source
Authors: Shen Lixin , Zhang Ziqiang , Wang Rui , Wu Shuang , Wang Yongjie , Fu Songzhe 
Published: December 2023

Abstract

Aims
Despite metatranscriptomics becoming an emerging tool for pathogen surveillance, very little is known about the feasibility of this approach for understanding the fate of human-derived pathogens in drinking water sources.

Methods and results
We conducted multiplexed microfluidic cards and metatranscriptomic sequencing of the drinking water source in a border city of North Korea in four seasons. Microfluidic card detected norovirus, hepatitis B virus (HBV), enterovirus, and Vibrio cholerae in the water. Phylogenetic analyses showed that environmental-derived sequences from norovirus GII.17, genotype C of HBV, and coxsackievirus A6 (CA6) were genetically related to the local clinical isolates. Meanwhile, metatranscriptomic assembly suggested that several bacterial pathogens, including Acinetobacter johnsonii and V. cholerae might be prevalent in the studied region. Metatranscriptomic analysis recovered 349 species-level groups with substantial viral diversity without detection of norovirus, HBV, and CA6. Seasonally distinct virus communities were also found. Specifically, 126, 73, 126, and 457 types of viruses were identified in spring, summer, autumn, and winter, respectively. The viromes were dominated by the Pisuviricota phylum, including members from Marnaviridae, Dicistroviridae, Luteoviridae, Potyviridae, Picornaviridae, Astroviridae, and Picobirnaviridae families. Further phylogenetic analyses of RNA (Ribonucleic Acid)-dependent RNA polymerase (RdRp) sequences showed a diverse set of picorna-like viruses associated with shellfish, of which several novel picorna-like viruses were also identified. Additionally, potential animal pathogens, including infectious bronchitis virus, Bat dicibavirus, Bat nodavirus, Bat picornavirus 2, infectious bursal disease virus, and Macrobrachium rosenbergii nodavirus were also identified.

Conclusions
Our data illustrate the divergence between microfluidic cards and metatranscriptomics, highlighting that the combination of both methods facilitates the source tracking of human viruses in challenging settings without sufficient clinical surveillance.
Preliminary comparative genomics analysis among Corynebacterium kroppenstedtii complex necessitates a reassessment of precise species associated with mastitis
Authors: Huang Ying , Song Ming-Hui , Li Shun-Guang , Yu Shen Hong- , Qu Ping-Hua , Zhang Dao-Feng 
Published: December 2023

Abstract

Aims
This study aimed to characterize the first complete genome of Corynebacterium parakroppenstedtii and clarify the evolutionary relationship in the Corynebacterium kroppenstedtii complex (CKC) by using comparative genomics analysis.

Methods and results
The genome of isolate yu01 from a breast specimen was sequenced, and 35 CKC genomes were collected. Analysis of 16S rRNA, rpoB, and fusA suggested ambiguous identification, whereas ANI analysis assigned isolate yu01 as Coryne. parakroppenstedtii. The fourth genospecies “Corynebacterium aliikroppenstedtii” was identified in CKC. Comparative genomics analysis suggested that the genomic arrangement in CKC was highly conserved. A total of 43 potential virulence genes and 79 species-specific genes were detected. Most genome-based phylogenetic analysis were incapable of resolving the interspecific evolutionary relationships among CKCs. A total of 20 core genes were found to be distinguishable in CKC.

Conclusions
This study suggested the limited divergence and unavailability of normal single gene-based identification in CKC and questioned the precise species of strains associated with mastitis, identified as Coryne. kroppenstedtii in previous studies. The 20 genes showed potential to enhance the methods for the identification and epidemiological investigation of CKC.
Revision of the Chinese freshwater crab genus Tenuipotamon Dai, 1990 (Decapoda: Brachyura: Potamidae), with the description of a new genus from southwestern China
Authors: Shi Boyang , Yeo Darren C J , Sun Hongying 
Published: December 2023

Abstract
The taxonomy of the potamiscine freshwater crab genus Tenuipotamon Dai, 1990, which contains seven species, is revised. According to a concurrent molecular phylogenetic study, Tenuipotamon is paraphyletic, and is composed of two lineages. In this study, Tenuipotamon sensu stricto is restricted to its type species, T. purpura Dai, 1990, while a new genus, Pusillamongen. nov., is established to accommodate the remaining six species placed previously in Tenuipotamon sensu stricto (T. baishuiense Chen, 1993, T. huaningense Dai & Bo, 1994, T. panxiense Chen, 1993, T. tonghaiense Chen, 1993, T. xinpingense Chen, 1993, and T. yuxiense Chen, 1993). Diagnoses are provided for the two genera, which are both endemic to the topographically complex Hengduan Mountains Region of southwestern China.
When Language Matters
Authors: Packard Grant , Li Yang , Berger Jonah 
Published: December 2023

Abstract
Text analysis is increasingly used for consumer and marketing insight. But while work has shed light on what firms should say to customers, when to say those things (e.g., within an advertisement or sales interaction) is less clear. Service employees, for example, could adopt a certain speaking style at a conversation's start, end, or throughout. When might specific language features be beneficial? This article introduces a novel approach to address this question. To demonstrate its potential, we apply it to warm and competent language. Prior research suggests that an affective (i.e., warm) speaking approach leads customers to think employees are less competent, so a cognitive (competent) style should be prioritized. In contrast, our theorizing, analysis of hundreds of real service conversations from two firms across thousands of conversational moments (N = 23,958), and four experiments (total N = 1,589) offer a more nuanced perspective. Customers are more satisfied when employees use both cognitive and affective language but at separate, specific times. Ancillary analyses show how this method can be applied to other language features. Taken together, this work offers a method to explore when language matters, sheds new light on the warmth/competence trade-off, and highlights ways to improve the customer experience.
High-throughput field phenotyping reveals that selection in breeding has affected the phenology and temperature response of wheat in the stem elongation phase
Authors: Roth Lukas , Kronenberg Lukas , Aasen Helge , Walter Achim , Hartung Jens , van Eeuwijk Fred , Piepho Hans-Peter , Hund Andreas 
Published: December 2023

Abstract
Crop growth and phenology are driven by seasonal changes in environmental variables, with temperature as one important factor. However, knowledge about genotype-specific temperature response and its influence on phenology is limited. Such information is fundamental to improve crop models and adapt selection strategies. We measured the increase in height of 352 European winter wheat varieties in 4 years to quantify phenology, and fitted an asymptotic temperature response model. The model used hourly fluctuations in temperature to parameterize the base temperature (Tmin), the temperature optimum (rmax), and the steepness (lrc) of growth responses. Our results show that higher Tmin and lrc relate to an earlier start and end of stem elongation. A higher rmax relates to an increased final height. Both final height and rmax decreased for varieties originating from the continental east of Europe towards the maritime west. A genome-wide association study (GWAS) indicated a quantitative inheritance and a large degree of independence among loci. Nevertheless, genomic prediction accuracies (GBLUPs) for Tmin and lrc were low (r≤0.32) compared with other traits (r≥0.59). As well as known, major genes related to vernalization, photoperiod, or dwarfing, the GWAS indicated additional, as yet unknown loci that dominate the temperature response.
The gender pay gap in medicine: evidence from Britain
Authors: Jones Melanie , Kaya Ezgi 
Published: December 2023

Abstract
This study quantifies the drivers of the gender pay gap among medical doctors in the British public sector, both at the mean and across the earnings distribution. We make comparisons to private sector doctors, as well as to other public sector health professionals and find that the substantial 22% hourly gender pay gap among public sector doctors, which is predominately unexplained by personal and work-related characteristics, is far larger than in these comparator occupations. Our evidence suggests sector–occupation-specific drivers of gender pay inequality among public sector doctors, which are particularly pronounced at the top end of the wage distribution.
Generating Informed Consent Documents Related to Blepharoplasty Using ChatGPT
Authors: Shiraishi Makoto , Tomioka Yoko , Miyakuni Ami , Moriwaki Yuta , Yang Rui , Oba Jun , Okazaki Mutsumi 
Published: December 2023

Purpose:
This study aimed to demonstrate the performance of the popular artificial intelligence (AI) language model, Chat Generative Pre-trained Transformer (ChatGPT) (OpenAI, San Francisco, CA, U.S.A.), in generating the informed consent (IC) document of blepharoplasty.

Methods:
A total of 2 prompts were provided to ChatGPT to generate IC documents. Four board-certified plastic surgeons and 4 nonmedical staff members evaluated the AI-generated IC documents and the original IC document currently used in the clinical setting. They assessed these documents in terms of accuracy, informativeness, and accessibility.

Results:
Among board-certified plastic surgeons, the initial AI-generated IC document scored significantly lower than the original IC document in accuracy (p < 0.001), informativeness (p = 0.005), and accessibility (p = 0.021), while the revised AI-generated IC document scored lower compared with the original document in accuracy (p = 0.03) and accessibility (p = 0.021). Among nonmedical staff members, no statistical significance of 2 AI-generated IC documents was observed compared with the original document in terms of accuracy, informativeness, and accessibility.

Conclusions:
The results showed that current ChatGPT cannot be used as a distinct patient education resource. However, it has the potential to make better IC documents when improving the professional terminology. This AI technology will eventually transform ophthalmic plastic surgery healthcare systematics by enhancing patient education and decision-making via IC documents.
Crush syndrome-related acute kidney injury in earthquake victims
Authors: Ramírez-Guerrero Gonzalo , Torres-Cifuentes Vicente 
Published: December 2023

ABSTRACT
Natural disasters are unpredictable and thousands of people are affected yearly. Currently, this risk persists, given the large population living in risk areas prone to suffering another seismic event. Generally, on-site mortality is high and occurs immediately from massive trauma or asphyxia. After surviving the first event, extricated patients are at risk of developing crush syndrome caused by direct physical trauma and compression of the human body with lesions in different tissues. This could lead to several systemic complications, including acute kidney injury (AKI), sepsis, acute respiratory distress syndrome, bleeding, hypovolemic shock, arrhythmias, electrolyte disturbances and disseminated intravascular coagulation. Hence, AKI in this scenario can occur due to many causes, such as rhabdomyolysis, direct renal trauma, hypovolemia and hemodynamic alterations. The most important measure to reduce crush syndrome mortality and prevent the development of crush syndrome-related AKI in disaster situations is the immediate start of treatment. Nevertheless, despite optimal therapy delivery, these previous efforts might not suffice the development and progression of AKI, consequently, the indication of extracorporeal blood purification techniques. This narrative review provides a focused overview of crush syndrome-related AKI, including etiology, mechanisms, diagnosis, current treatment, removal of myoglobin and their limitations.
Pediatric tuina for recurrent respiratory tract infection in children: A systematic review and meta-analysis
Authors: Wang Xiaoyu , Yin Lianjun , Bai Xue , Mao Zefang , Wang Yikun , Li Huanan , Wang Jingui 
Published: December 2023

Background:
To evaluate the effects and safety of pediatric tuina for recurrent respiratory tract infections (RRTIs).

Methods:
Web of Science, PubMed, Cochrane Library, Embase, CNKI, Wanfang Data, VIP, and CBM databases were searched from inception to September 20 2023. Two authors independently selected studies, collected data, and evaluated methodological quality using the Cochrane Risk of Bias tool. Revman 5.4 was used for the meta-analysis.

Results:
Fifteen randomized controlled trials involving 1420 pediatric patients were included in this meta-analysis. The meta-analysis indicated that pediatric tuina significantly reduced the incidence of RRTIs [MD −1.11, 95% confidence interval (CI) (−1.77, −0.46)], decreased infection duration (MD −1.16 days, 95% CI [− 1.66, − 0.66]), improved IgA (MD 0.25 g/L, 95% CI [0.09, 0.41]), IgG (MD 1.64 g/L; 95% CI [0.82, 2.45]), CD3+ (MD 3.33%, 95% CI [0.74, 5.92]), CD4+ (MD 4.78%, 95% CI [2.08, 7.48]), CD4+/CD8+ ratio (MD 0.27%, 95% CI [0.08, 0.47]), and total effective rate (RR 1.19, 95% CI [1.13, 1.25]). However, IgM levels (MD 0.26 g/L, 95% CI [−0.26, 0.81]) and CD8+ (MD −1.36%, 95% CI [− 3.12, 0.41]) were not significantly different between the groups. Moreover, no Tuina-linked adverse reactions were observed.

Conclusion:
Pediatric tuina has shown positive effects in RRTIs treatment. However, these results should be interpreted with caution owing to study quality. Further large-scale and high-quality randomized controlled trials are warranted to confirm these findings.