bluuebunny/crossref_metadata_2025_split huggingface dataset:
Penggunaan Tanda Tangan Elektronik Pada Sertipikat Hak Tanggungan Elektronik
Authors: Pratama Edwin Yoga , Sa'adah Nabitatus 
Published: December 2023

AbstractAn digital signature is an electronically generated signature that functions the same as a regular signature on paper documents. Electronic documentscan be categorized as written evidence, legal principle that makes it difficult to developt the use of electronic documents, the document must be viewable, sent and stored in paper form and also digital data is data that is very vulnerable to engineering. The theory of this research is Gustav Radbruch's theory of legal goals, it is necessary to use the principle of the primacy of three basic values that are the objectives of the law, namely: legal justice, legal expediency and legal certainty and the writing method used is normative juridical. The results is that this electronic signature has been registered with the BSSN, therefore the electronic signature issued is guaranteed because BSSN is one of the bodies trusted by the State, UU ITE has recognized that electronic documents and electronic signatures can be used as legal and perfect evidence, the efforts of the national land agency office are that BPN already has two validated applications, namely veryds and PDF writer, BPN also has its own server only registered users can access the data.Keyword: digital signature; document; electronicAbstrakTanda tangan elektronik adalah tanda tangan yang dibuat secara elektronik, bertindak serupa dengan tanda tangan umumnya pada dokumen kertas. Dokumen elektronik bisa dikelompokkan selaku bukti tertulis, prinsip hukum yang mengakibatkan sukarnya pengembangan penggunaan serta dokumen elektronik, dokumen tersebut haruslah bisa dilihat, dikirim serta disimpan kedalam wujud kertas dan juga mengenai data digital merupakan data yang sangat rentan untuk di rekayasa. Teori penelitian ini adalah teori tujuan hukum Gustav Radbruch, perlunya menggunakan asas prioritas dari tiga nilai dasar yang menjadi tujuan hukum, diantaranya: keadilan hukum, kemanfaatan hukum, kepastian hukum serta metode penulisan yang dipergunakan ialah yuridis normatif. Hasil penelitian ini adalah bahwasanya tanda tangan elektronik ini sudah didaftarkan ke BSSN, maka dari itu tanda tangan elektronik yang dikeluarkan sudah terjamin karna BSSN salah satu badan yang dipercaya oleh Negara, UU ITE sudah mengakui bahwa dokumen elektronik serta tanda tangan elektronik mampu dipergunakan selaku alat bukti yang sah dan sempurna, upaya dari kantor badan pertanahan nasional yakni bahwa BPN telah memiliki dua aplikasi tervalidasi yakni veryds dan PDF writer, BPN juga telah memiliki server sendiri hanya pengguna terdaftar saja yang bisa mengakses data.Kata kunci: tanda tangan elektronik; dokumen; elektronik
Newborn screening for primary carnitine deficiency using a second-tier genetic test
Authors: Lin Yiming , Lin Chunmei , Zheng Zhenzhu , Huang Chenggang , Peng Weilin 
Published: December 2023

Abstract

Objectives
Newborn screening (NBS) for primary carnitine deficiency (PCD) exhibits suboptimal performance. This study proposes a strategy to enhance the efficacy of second-tier genetic screening by adjusting the cutoff value for free carnitine (C0).

Methods
Between January 2021 and December 2022, we screened 119,898 neonates for inborn metabolic disorders. Neonates with C0 levels below 12 μmol/L were randomly selected for second-tier genetic screening, employing a novel matrix-assisted laser desorption/ionization-time of flight mass spectrometry (MALDI-TOF MS) assay.

Results
In total, 2,515 neonates with C0 <12 μmol/L underwent further screening, including 206 neonates with C0 <8.5 μmol/L and 320 neonates with 8.5<C0<12 μmol/L. Genetic screening identified positive results in 12.36 % (65) of neonates, with one being homozygous, 10 compound heterozygotes, and 54 heterozygotes. Sanger sequencing revealed a second SLC22A5 variant in three of the 54 neonates. Ultimately, 14 patients were diagnosed with PCD; all 14 patients exhibited low C0 levels, though two had normal C0 levels during the recall review. The MALDI-TOF MS assay demonstrated detection and diagnostic rates of 89.29 % and 78.57 %, respectively. Eleven distinct SLC22A5 variants were identified, with the most common variant being c.51C>G, accounting for 25 % (7/28) of allelic frequencies.

Conclusions
A novel MALDI-TOF MS assay targeting 21 SLC22A5 variants in a Chinese population was successfully established. This assay exhibits a high detection and diagnostic rate, making it suitable for population-based genetic screening. Combined genetic screening is recommended to enhance the efficiency of PCD–NBS.
Expression levels of genes involved in lipogenesis and cholesterol synthesis in adenomyosis
Authors: Yalaza Cem , Antmen Şerife Efsun , Canacankatan Necmiye , Tuncel Ferah , Aytan Hakan , Erden Ertürk Sema 
Published: December 2023

Abstract

Objectives
Adenomyosis is a benign uterine disease that occurs with the invasion of the endometrial gland and stoma into the myometrium. The etiology and molecular pathology of adenomyosis are not yet fully understood. Tissue samples of patients diagnosed with adenomyosis and healthy endometrial tissues were investigated for the lipogenesis and cholesterol synthesis pathways. It was aimed to determine the difference between adenomyosis and healthy endometrial tissues in terms of lipid metabolism and to investigate the mechanism of adenomyosis in this context.

Methods
Formalin-fixed paraffin-embedded archival tissues were used in the current retrospective study. A total of 76 patient samples and 3 groups were used. Group 1: adenomyotic tissue (n=28), Group 2: eutopic endometrial tissue (n=30), and Control Group (n=18). In these groups, Sterol regulatory element binding protein 1 (SREBP1) molecule, fatty acid synthase (FASN), acetyl-CoA carboxylase (ACACA), ATP-citrate lyase (ACLY), HMG-CoA reductase (HMGCR), and HMG-CoA synthase (HMGCS) markers were evaluated by using RT-PCR method.

Results
Statistically significant differences (p<0.05) were found between the groups regarding expression levels of HMGCR, HMGCS, ACLY, ACACA, and SREBP1. HMGCR, HMGCS, ACLY, and SREBP1 gene expression levels between Group 1 and Group 2 and HMGCS, ACACA, ACLY, and SREBP1 gene expression levels between Group 1 and Control Group were determined as statistically different. A significant difference was detected only in HMGCR gene expression levels between Group 2 and the Control Group.

Conclusions
These results show that genes involved in lipid metabolism may be associated with the molecular pathogenesis of adenomyosis.
Ternary magnetic silica–graphene oxide composite for remediation of textile dyes from aqueous environment and real samples
Authors: Saleh Al-Makhathi Ameen Ahmed , Khan Hamayun , Malik Sumeet , Taube Paulo S. , Ara Behisht , Gul Kashif , Khan Adnan 
Published: December 2023

Abstract
Inadequate wastewater treatment infrastructure is a substantial worldwide concern, with implications for both the environment and public health. Specifically, the discharge of industrial effluents containing organic pollutants such as dyes represents a significant challenge due to their hazardous characteristics. Among these dyes, Bromophenol Blue (BPB) and Malachite green (MG) are extensively utilized in the industrial sector, contributing to environmental deterioration. In the current study, ternary-magnetic-silicate–graphene oxide [Fe3O4@SiO2–GO] was synthesized using the co-precipitation method and applied for the treatment of wastewater containing BPB and MG dyes. The point of zero charge and surface area of the adsorbent was estimated to be 5.7 and 253.8 m2 g−1, respectively. Energy dispersive X-ray was performed and the presence of iron, silicon, carbon, and oxygen was confirmed. The XRD analysis of GO, Fe3O4, and ternary Fe3O4@SiO2–GO composites were also performed to confirm the crystallinity of the composite. The SEM analysis showed a rough morphology with sheet-like appearance. The ternary composite was then applied for the adsorption of BPB and MG dyes. The maximum adsorption capacity for BPB and MG was 97.35 mg/g and 92.63 mg/g at pH 3 and 5, respectively. The results of the kinetics analysis showed that the pseudo-second-order kinetics model best explained the adsorption data for MG dye while pseudo-first-order kinetics for the BPB dyes. While the data best fitted the Langmuir adsorption isotherm with R
2 values of 0.994 and 0.998 for BPB and MG, respectively. These results demonstrate that Fe3O4@SiO2–GO serves as a promising adsorbent for the efficient removal of Bromophenol Blue (BPB) and Malachite Green (MG) from environmental water samples. Additionally, this adsorbent is environmentally friendly and chemically benign, and it can be reused efficiently for up to five cycles.
The benefit of a four-week range of motion exercise on hand muscle strength in children with Down Syndrome
Authors: Raharjo Slamet , Yunus Mahmud , Pelana Ramdan , Azidin Raja Mohammed Firhad Raja 
Published: December 2023

Background and Study Aim. Down syndrome is linked to motor disorders, leading to reduced physical activity and fitness, including diminished aerobic endurance and muscle strength. Study Aim - to investigate the efficacy of range of motion exercises in enhancing hand muscle strength in children with Down syndrome.
Material and Methods. This research employed a true experimental approach with a pre-test and post-test control group design. The study sample consisted of 18 children with Down syndrome, aged between 10 to 12 years. The selected participants underwent range of motion exercises, which were systematically conducted 3 times a week over a span of 4 weeks. To assess the efficacy of the exercises, hand muscle strength was gauged both before and after the intervention. The measurement tool utilized was a Handgrip Strength (HGS) test, executed with the aid of a Takei dynamometer, ensuring accuracy and consistency in the results. For the statistical analysis of the collected data, a paired sample t-test was employed. The threshold for statistical significance was set at a p-value of less than 0.05 or 5%.
Results. The range of motion exercise, when carried out for 4 weeks, has been shown to increase hand muscle strength in children with Down syndrome. Based on the results of statistical analysis of hand muscle strength pretest and posttest in the control group (CtrG) (6.06 ± 2.11 vs. 6.13 ± 2.23 kg, p ≥ 0.05), and the experimental group (ExpG) (6.10 ± 2.68 vs. 8.95 ± 2.69 kg, p ≤ 0.001).
Conclusions. These exercises play a pivotal role in boosting muscle strength in children with Down syndrome. Emphasizing their physical health, especially muscle strength, is vital for their current educational pursuits and future well-being.
The Development of Website-based Faimathematics in Mathematics Learning to Increase Student Learning Interest
Authors: Nurdiansyah Ahmad Rifai , Kusumah Yaya Sukjaya , Priatna Bambang Avip 
Published: December 2023

Tujuan penelitian ini adalah untuk mengembangkan Faimathematics berbasis website dalam pembelajaran matematika untuk meningkatkan minat belajar siswa. Penelitian pengembangan ini menggunakan metode Research and Development (R&D) dengan model ADDIE yang terdiri dari 5 tahapan yaitu Analysis, Design, Development, Implementation, and Evaluation. Produk yang dihasilkan adalah media pembelajaran berbasis website (Faimathematics). Teknik pengumpulan data yang digunakan dalam penelitian ini adalah non tes berupa lembar validasi dan angket minat belajar. Subjek penelitian ini terdiri dari 6 orang siswa kelas IX A pada skala kecil dan 23 orang siswa kelas IX B pada skala besar di SMPN. Hasil penelitian ini menunjukkan: validitas ahli media dengan kriteria sangat valid, validitas ahli materi dengan kriteria sangat valid, validitas ahli pedagogik dengan kriteria sangat valid, dan validitas ahli bahasa dengan kriteria sangat valid. Hasil uji praktikalitas oleh siswa pada uji coba skala kecil mendapat hasil sangat praktis, hasil uji praktikalitas oleh siswa pada uji coba skala besar mendapat hasil praktis, dan hasil uji praktikalitas oleh guru mendapat hasil praktis. Peningkatan minat belajar siswa setelah mengikuti pembelajaran matematika dengan menggunakan Faimathematics termasuk dalam kategori sedang. The purpose of this study is to develop website-based Faimathematics in mathematics learning to improve students learning interest. This development research uses the Research and Development (R&D) method with the ADDIE model which consists of 5 stages namely Analysis, Design, Development, Implementation, and Evaluation. The resulting product is a website-based learning media (Faimathematics). The Data collection techniques used in this study were a non-test in the form of validation sheets and interest in learning questionnaires. The subjects of this study consisted of 6 students of class IX A on a small scale and 23 students of class IX B on a large scale at SMPN. The results showed: The validity of media experts with very valid criteria, the validity of material experts with very valid criteria, the validity of pedagogic experts with very valid criteria, and the validity of linguists with very valid criteria. The results of practicality tests by students in small-scale trials got very practical results, the results of practicality tests by students in large-scale trials got practical results, and the results of practicality tests by teachers got practical results. Increasing students' interest in learning after participating in learning mathematics using Faimathematics is included in the medium category.
DESENVOLVIMENTO DE TECNOLOGIAS SUSTENTÁVEIS PARA O ARRANJO PRODUTIVO LOCAL DE CAULIM NOS PEGMATITOS RN/PB
Authors: Marvila de Almeida Kayrone , Wilson Hollanda VIdal Francisco , Ferreira Sousa Antônio Pedro , Fernández Castro Nuria 
Published: December 2023

A região do Seridó, situada no Nordeste brasileiro, nos estados da Paraíba e do Rio Grande do Norte, é conhecida por suas vastas reservas de caulim oriundas de pegmatitos. Pequenas empresas fazem o processo de extração e beneficiamento do minério. No entanto, essas operações são precárias. A falta de planejamento na lavra e no processo de beneficiamento faz com que os pequenos produtores de caulim tenham apenas um aproveitamento de 25%, e diversos acidentes causados na etapa de extração. O projeto Entidades Associadas do Centro de Tecnologia Mineral – CETEM/MCTI, em parceria com a Universidade Federal de Campina Grande - UFCG foi criado para desenvolver ações integradas de pesquisa, tecnologias e inovação para agregar valor à cadeia produtiva mineral na região do Seridó. Foi elaborado um plano de trabalho onde se fez o levantamento de informações da área. Foram coletados dados em campo e utilizados na elaboração de mapas e modelos geológicos para cálculo de cubagem, utilizando software computacional. Além disso, foi montada uma planta piloto de beneficiamento de caulim utilizando hidrociclone, visando o aumento de recuperação do mineral minério. Na etapa de planejamento de lavra foram elaborados dois cenários de lavra com características geométricas distintas. O primeiro cenário apresentou resultados melhores que o segundo. A tonelada de minério foi maior e a relação estéril minério menor. No processo de beneficiamento a recuperação de caulim apresentou bom resultado. O concentrado do processo apresentou altas porcentagens de caulinita. O projeto de lavra e beneficiamento mostrou a possibilidade de extrair e tratar um minério de forma mais segura e viável economicamente.
DANÇANDO O CARIMBÓ NA ESCOLA
Authors: Pimenta Verônica Teodora , Dantas Julia Medeiros 
Published: December 2023

Este artigo trata da Dança no currículo formal da Educação Básica, visando à construção de conhecimentos por meio de vivências com Danças Brasileiras, especificamente o carimbó. A metodologia envolveu o projeto interdisciplinar “Carimbó, cultura regional e desenvolvimento sustentável”, com estudantes do 4º Ano do Colégio de Aplicação da Universidade Federal de Roraima. Partimos do entendimento de Pedagogia de Projeto, com planejamentos de sequências didáticas simultâneas em Língua Portuguesa, Geografia, Dança, Música e Educação Física. Trazemos reflexões sobre a experiência interdisciplinar nos componentes Dança e Educação Física. Foram essas as seguintes etapas de construção do conhecimento: pesquisas envolvendo a história do carimbó e suas características, vivências de roda de carimbó na sala de aula, rodas de conversa, além da experiência performativa, na culminância do projeto fora da sala de aula, com rodas de carimbó com música ao vivo e a presença de integrantes da comunidade escolar, incluindo familiares das crianças. Essa experiência implicou no reconhecimento do carimbó enquanto patrimônio cultural e fruto da resistência de comunidades populares do Pará. Devido à natureza performativa e festiva da roda, o carimbó também foi o ponto de partida para reflexões sobre modelos de inclusão do corpo no espaço escolar. O reconhecimento do carimbó enquanto patrimônio contou, especialmente, com a aproximação afetiva da dança, além da descoberta dessa manifestação como uma resistência afro-ameríndia. Para além de um tradicional Pedagogia de Dança, reconhecemos na memória do carimbó, nos seus elementos festivos e nas influências recebidas da cosmovisão indígena, caminhos para possíveis Pedagogias Decoloniais em Dança.
BRINCANDO DE VIVER
Authors: Campos Camila Amorim , Caldeira Maria Carolina da Silva 
Published: December 2023

Este artigo mostra que criar novas formas de vida no currículo com festas é criar uma vida outra apesar de todos os poderes que insistem em enclausurar vidas. É abrir-se à alegria de brincar e ao desejo de viver. Para tanto tem como objetivo analisar como um corpo esgotado cria modos de existências no currículo com festas. Argumentamos que um corpo esgotado, em um dia de festa, ao traçar linhas de fuga para sobreviver, experimenta novas formas de vida e brinca de viver ao experimentar as potencialidades do corpo no currículo. Mostramos como um corpo que parecia ter sua vida marcada pelas incertezas e pelas aflições, um corpo esgotado, em um currículo com festas, brinca de viver. Isso porque ao entrar em devir percorre novos caminhos, explora, cria novos mundos, brinca de viver, sorri. O corpo esgotado, tão marcado e muitas vezes silencioso e silenciado, mostrou que há sempre novos passos a serem dançados no currículo com festas. Mostrou que um corpo em devir-criança espanta. Espanta ao sorrir. Porque cria singularidades, momentos. Evidencia que os seus agenciamentos possibilitam linhas de fuga.
Mostar Benefactors: Babusaade Agha Ahmed Agha and his Endowment
Authors: KADRİC Adnan , HODZİC Muamer 
Published: December 2023

This paper emphasizes the significance of waqfs in the development of Mostar. Thanks to that institution, Mostar has become one of the largest cultural and economic centers in Eyalet of Bosnia. Special
attention was given to the waqf of Babussaade Agha, Ahmed Agha. His waqfiye, which is an integral part of this work, contains information about new buildings, money and other things endowed by the aforementioned Ahmed Agha. It also includes changes to some of his previous waqfiya’s stipulations. His endowments in Istanbul and Mostar are mentioned in the waqfiye. Because little is known about his waqf in Mostar, this work aims to draw attention to the waqfiya’s text. The content of Ahmed Aga’s waqfiye demonstrates the importance of his waqf for cultural life in Mostar and his role in enlightening local imams and students.
Influence of Different Thicknesses of Monolithic Crowns Made from Different Resin-Bonded Glass Ceramic on Their Load-bearing Capacity (An in vitro Comparative Study)
Authors: Abdalla Azad , Al-Zahawi Abdulsalam 
Published: December 2023

Objective: To investigate the load-bearing capacity of the full-coverage crowns made from lithium disilicate glass-ceramic LDGC (IPS e.max®, Ivoclar Vivadent) and 10% zirconia reinforced lithium silicate glass ceramic ZLS (Dentsply DeTrey) with different thicknesses.
Methods: Forty resin dies with supporting bases were duplicated from two prepared typodont teeth for all-ceramic crowns as a maxillary first molar. Forty crowns corresponding to each die were prepared and then they were divided into four groups: Group I (n 10) made from ZLS with a restoration thickness of (1.0 mm occlusally and 1.0 mm radially) and Group II (n 10) made from LDGC with a restoration thickness of (1.0 mm occlusally and 1.0 mm radially), and Group III (n 10) made from ZLS (1.5 mm occlusally and 1.5mm radially) and Group IV (n 10) made from LDGC (1.5 mm occlusally and 1.5 radially). All crowns were fabricated by chair side CEREC CAD/CAM and crystallized with Speed fire Dentsply Furness. The virolink resin cement (VariolinkII, Ivoclar Vivadent) was used to bond the crowns to the corresponding dies. All samples were thermo-cycled (10000 cycles between 5c and 55c) and tested for fracture resistance using a Universal testing machine at 0.5 mm/minute speed until failure. ANOVA and Tukey HSD test were used to compare the fracture resistance between groups.
Results: The result demonstrates that the fracture resistance means and SD of ZLS with different thicknesses ranged from 572 N ± 122.002 to 1171±217.432 N, and those of LDGC with different thicknesses ranged from 625 N ±151.676 N to 845 N ±388.222 N.
Conclusions: The fracture resistance increased with increasing crown thickness using different glass-ceramic materials.
Effect of Different Obturation Techniques on the Amount of Debris Extrusion During Endodontic Retreatment Using XP Endo Retreatment Set Files (In vitro Study)
Authors: Amin Pawan , Saeed Hawzhen 
Published: December 2023

Objective: This study aimed to assess the effect of the cold and warm obturation techniques on the amount of apically extruded debris (AED) and time needed for the removal of filling material during endodontic retreatment using the XP endo retreatment files.
Methods: Sixty single-rooted lower premolars with round-shaped canals were selected for the study. The canals were prepared and obturated with one of four obturation techniques (N=15): cold lateral compaction (CLC), single-cone (SC), thermoplasticized gutta percha injection (TGP), and gutta core (GC) obturation techniques. All the root canal fillings were removed using XP endodontic retreatment files. The mean weight of the AED was estimated with an analytical balance to an accuracy of 10-4 g. AED data were subjected to Kruskal-Wallis and a one-way ANOVA, post hoc Tukey's test for the time factor, with a significance level ≤ 0.05.
Results: AED data revealed significant differences among groups (p=0.039). The CLC technique was significant compared to TGP, with a significance level of p=0.018, and significant compared to the SC technique, with a significance level of p=0.034. Also, there were highly significant differences between groups regarding the time needed for retreatment (p=0.000).
Conclusions: The obturation technique influences AED, and time for root canal retreatment. CLC resulted in less debris extrusion, while SC resulted in higher debris extrusion and TGP required the least time for root canal retreatment.