bluuebunny/crossref_metadata_2025_split huggingface dataset:
Modeling and solving the multi-objective energy-efficient production planning and scheduling with imperfect maintenance activities
Authors: Rastgar Iman , Rezaeian Javad , Mahdavi Iraj , Fattahi Parviz 
Published: November 2023

PurposeThe purpose of this study is to propose a new mathematical model that integrates strategic decision-making with tactical-operational decision-making in order to optimize production and scheduling decisions.Design/methodology/approachThis study presents a multi-objective optimization framework to make production planning, scheduling and maintenance decisions. An epsilon-constraint method is used to solve small instances of the model, while new hybrid optimization algorithms, including multi-objective particle swarm optimization (MOPSO), non-dominated sorting genetic algorithm, multi-objective harmony search and improved multi-objective harmony search (IMOHS) are developed to address the high complexity of large-scale problems.FindingsThe computational results demonstrate that the metaheuristic algorithms are effective in obtaining economic solutions within a reasonable computational time. In particular, the results show that the IMOHS algorithm is able to provide optimal Pareto solutions for the proposed model compared to the other three algorithms.Originality/valueThis study presents a new mathematical model that simultaneously determines green production planning and scheduling decisions by minimizing the sum of the total cost, makespan, lateness and energy consumption criteria. Integrating production and scheduling of a shop floor is critical for achieving optimal operational performance in production planning. To the best of the authors' knowledge, the integration of production planning and maintenance has not been adequately addressed.
Can green finance promote high-quality energy development? The case of China
Authors: Wang Bo , Dong Kangyin , Taghizadeh-Hesary Farhad 
Published: November 2023

PurposeChina is a significant energy consumer with increasingly severe resource constraints and environmental problems, requiring low-carbon energy transformation and encouraging high-quality energy development (HED). Green finance significantly affects the effect on HED as a cutting-edge financial strategy to support environmental improvement and encourage green development.Design/methodology/approachUsing panel data from 30 provinces from 2007 to 2019 and the system-generalized method of moments method, this paper investigates the impact of green finance on HED, and further explores their threshold effect, heterogeneous and asymmetry analysis.FindingsThe main results indicate that: (1) green finance positively affects HED in China; in other words, a 1% increase in the green finance index will boost HED by an average of 0.767%; (2) as the economy improves, the positive impact of green finance on HED will be even more significant and (3) the contribution of green finance to HED is more significant in the northern provinces and areas with lower HED levels.Originality/valueThis paper puts forward relevant policy suggestions to further improve the construction of the green financial system.
High-speed rail network and earnings management techniques usage trade-off: the moderating effects of governance and religion
Authors: Li Bin , Qizi Zhao , Shahab Yasir , Wu Xun , Ntim Collins G. 
Published: November 2023

Purpose
This study aims to investigate the impact of the development of high-speed rail (HSR) network on earnings management, especially on the trade-off between the usage of accruals-based earnings management (AM) and real earnings management (RM) techniques, and consequently, examines the extent to which the HSR network–earnings management nexus is moderated by governance and religion factors.

Design/methodology/approach
Using a sample of Chinese A-listed firms over an 11-year period, this study uses regression techniques as the baseline methodology while controlling for industry and year-fixed effects. The authors also use endogeneity tests (including instrumental variable method, Generalized Methods of Moments estimation and difference-in-difference) and different robustness checks.

Findings
The key findings are threefold. First, the HSR network development reduces AM. This suggests that the presence of HSR network is effective in reducing information asymmetry. Second, the use of RM technique increases with the HSR network development. This indicates that managers do not seem to engage in less earnings management with the HSR network development but instead appear to switch from the easy-to-detect AM to the more costly RM approach. Finally, the HSR network and earnings management nexus is moderated by governance and religion factors.

Originality/value
This study provides new evidence on the trade-off between AM and RM by managers and pioneers in examining the impacts of governance and religion factors on the relationship between the HSR network and the trade-off of earnings management techniques.
Influence of artificial intelligence (AI) perception on career resilience and informal learning
Authors: Kong Haiyan , Jiang Xinyu , Zhou Xiaoge , Baum Tom , Li Jinghan , Yu Jinhan 
Published: November 2023

Purpose
Artificial intelligence (AI) and big data analysis may further enhance the automated and smart features of tourism and hospitality services. However, it also poses new challenges to human resource management. This study aims to explore the direct and indirect effects of employees’ AI perception on career resilience and informal learning as well as the mediating effect of career resilience.

Design/methodology/approach
This paper proposed a theoretical model of AI perception, career resilience and informal learning with perceived AI as the antecedent variable, career resilience as the mediate variable and informal learning as the endogenous variable. Targeting the employees working with AI, a total of 472 valid data were collected. Data were analyzed using structural equation modeling with AMOS software.

Findings
Findings indicated that employees’ perception of AI positively contributes to career resilience and informal learning. Apart from the direct effect on informal learning, career resilience also mediates the relationship between AI perception and informal learning.

Originality/value
Research findings provide both theoretical and practical implications by revealing the impact of AI perception on employees’ career development, leaning activities, explaining how AI transforms the nature of work and career development and shedding lights on human resource management in the tourism and hospitality field.
Association of ATG16L1 and ATG5 gene polymorphisms with susceptibility to hepatitis B virus infection and progression to HCC in central China
Authors: Wu Qiaoyu , Ouyang Yaoling 
Published: November 2023

AbstractHepatitis B virus (HBV) infection is a severe public health problem worldwide. The relationship between polymorphisms of autophagy‐related 16‐like 1 gene (ATG16L1) and autophagy‐related gene 5 (ATG5) with susceptibility to the stage of HBV infection has been reported in different populations. Nevertheless, this association is not seen in the population of central China. This study recruited 452 participants, including 246 HBV‐infected patients (139 chronically infected HBV without hepatocellular carcinoma [HCC] and 107 HBV‐related HCC patients) and 206 healthy controls. Genotyping of ATG16L1 rs2241880 and ATG5 rs688810 were performed using Sanger sequencing and polymerase chain reaction‐restriction fragment length polymorphism, respectively. Our results indicated that the G allele of ATG16L1 rs2241880 was more frequent in healthy controls than in patients with chronicHBV infection. After adjusting for age and sex, an association between the ATG16L1 rs2241880 polymorphism and HBV infection was significant under the dominant and allele models (p = 0.009 and 0.003, respectively). However, no association between the ATG5 polymorphisms and HBV infection was observed. We also did not find a significant association between ATG16L1 and ATG5 polymorphisms and the progression of HBV‐related HCC. Therefore, the genetic polymorphism of ATG16L1 rs2241880 may be associated with susceptibility to HBV infection in the population of central China.
Landscape heterogeneity can partially offset negative effects of habitat loss on mammalian biodiversity in agroecosystems
Authors: do Carmo Pônzio Marcella , Pasqualotto Nielson , Zanin Marina , Chiarello Adriano Garcia , Pardini Renata 
Published: November 2023

Abstract

Intensive, large‐scale agriculture promotes the conversion of natural habitats and diversified crops into monocultures, decreasing both native vegetation cover and landscape heterogeneity, leading to landscape simplification. Yet, a key knowledge gap persists on the relative impacts of the loss of native vegetation and landscape heterogeneity on biodiversity. Addressing this gap is pressing to support policies that conciliate agricultural production and biodiversity conservation and to move forward some scientific controversies, as the ‘land sharing versus land sparing’ and ‘habitat loss versus fragmentation’ debates.

Through a hierarchical sampling design that maximised variation, while minimising correlation, between landscape heterogeneity and native vegetation cover, we recorded the occurrence of medium and large‐bodied mammals in native vegetation and agricultural areas of 55 landscapes in a global conservation hotspot and a key commodity production area—the Brazilian Savanna, Cerrado. We compared simple, additive and interactive models to investigate the effects of landscape heterogeneity and native vegetation cover on richness and composition of native and invasive mammals.

Native and invasive mammal communities were affected by both native vegetation cover and landscape heterogeneity, although the effects of the first was stronger than the later. Both aspects had positive effects on native species richness and negative effects on invasive species richness, indicating that the loss of native vegetation and the reduction in landscape heterogeneity lead to biotic homogenisation. Yet, while landscape heterogeneity benefited most native species, the direction of its effect varied among invasive species and depended on native vegetation cover.

Synthesis and applications. Besides reducing habitat loss, avoiding landscape homogenisation is key for conciliating agricultural production and biodiversity conservation, pointing to the relevance of policies encouraging crop diversification. As increasing landscape heterogeneity can in part compensate the negative effects of losing native habitat on biodiversity in agroecosystems, policies can gain feasibility by adjusting the balance between native vegetation cover and landscape heterogeneity according to what best suits local restraints and demands.
The mechanisms underlying alcohol‐induced decreased splenic size: A network meta‐analysis study
Authors: Liu Xiangqian , Bishir Muhammed , Hodgkinson Colin , Goldman David , Chang Sulie L. 
Published: November 2023

AbstractBackgroundOrgan weight change is widely accepted as a measure of toxicologic pathology. We and other groups have shown that excessive alcohol exposure leads to decreased spleen weight in rodents. This study explores the mechanisms underlying alcohol‐induced splenic injury through a network meta‐analysis.MethodsQIAGEN Ingenuity Pathway Analysis (IPA) and Mammalian Phenotype (MP) Ontology were used to identify alcohol‐related molecules associated with the small spleen phenotype. Search Tool for the Retrieval of Interacting Genes/Proteins (STRING) and IPA bioinformatics tools were then used to analyze the biologic processes and enriched signaling pathways engaging these molecules. In addition, the “downstream effects analysis” algorithm was used to quantify alcohol's effects.ResultsIPA identified 623 molecules affected by alcohol and a Venn diagram revealed that 26 of these molecules overlapped with those associated with the MP Ontology of small spleen. The 26 molecules are TGFB1, CASP8, MTOR, ESR1, CXCR4, CAMK4, NFKBIA, DRD2, BCL2, FAS, PEBP1, TRAF2, ATM, IGHM, EDNRB, MDM2, GLRA1, PRF1, TLR7, IFNG, ALOX5, FOXO1, IL15, APOE, IKBKG, and RORA. Some of the 26 molecules were also associated with the MP Ontology of abnormal white pulp and red pulp morphology of the spleen, abnormal splenic cell ratio, decreased splenocyte number, abnormal spleen physiology, increased splenocyte apoptosis, and reduced splenocyte proliferation. STRING and IPA “Core Analysis” showed that these molecules were mainly involved in pathways related to cell apoptosis, proliferation, migration, and immune responses. IPA's “Molecular Activity Predictor” tool showed that concurrent effects of activation and inhibition of these molecules led to decreased spleen size by modulating apoptosis, proliferation, and migration of splenocytes.ConclusionsOur network meta‐analysis revealed that excessive alcohol exposure can damage the spleen through a variety of molecular mechanisms, thereby affecting immune function and human health. We found that alcohol‐mediated splenic atrophy is largely mediated by increased apoptosis signaling, migration of cells, and inhibition of splenocyte proliferation.
Central macular morphology and optic nerve fibre layer thickness in young adults born premature and screened for retinopathy of prematurity
Authors: Pétursdóttir Dýrleif , Åkerblom Hanna , Holmström Gerd , Larsson Eva 
Published: November 2023

AbstractPurposeTo investigate central retinal morphology and optic retinal nerve fibre layer (RNFL) in prematurely born young adults and compare to term born controls.Materials and MethodsThe participants were 59 prematurely born individuals, with a birthweight ≤1.500 g, and 44 term born controls, all 25–29 years of age. Visual acuity (VA) and contrast sensitivity (CS) were assessed. The retinal macular thickness, ganglion cell‐inner plexiform layer (GC‐IPL) thickness and RNFL thickness were assessed with Cirrus optical coherence tomography (OCT).ResultsCentral macular thickness was increased (mean 26.7 μm) in prematurely born individuals compared to controls. The macular GC‐IPL was thinner (mean 3.84 μm), also when excluding those with previous retinopathy of prematurity (ROP) and those with neurological complications. Gestational age at birth and previous treatment of ROP were risk factors for a thicker macula, however, not for reduced GC‐IPL. The average peripapillary RNFL was thinner (mean 4.61 μm) in the prematurely born individuals, also when excluding those with previous ROP and/or neurological complications. Within the prematurely born group, treated ROP was correlated with increased average RNFL. Further, both better VA and CS were associated with thinner optic nerve RNFL and thicker average GC‐IPL.ConclusionMacular and optic nerve morphology were influenced by premature birth as assessed with OCT in adult individuals. Gestational age at birth and treatment for ROP seemed to affect central macular thickness, and treated ROP affected the peripapillary RNFL. Thus, retinal sequelae remained in adulthood.
Management of neonatal hypoglycaemia in a tertiary maternity unit—A multidisciplinary quality improvement project
Authors: Garvey Aisling , Kearney Avril , Kasha Sarah , Dafalla Ibrahim , Moore Shirley , Wall Hilda , Curley Anna 
Published: November 2023

AbstractAimImproved identification and treatment of infants at risk of hypoglycaemia using evidence‐based guidelines.MethodsDesign: Prospective, multidisciplinary quality improvement project (QIP). Setting: Tertiary maternity hospital, Dublin (2016–2023). Subjects: Infants at risk for neonatal hypoglycaemia. Intervention: Plan‐Do‐Study‐Act methodology. A hospital‐wide survey and ongoing audit informed our initiatives including staff education, antenatal maternal education and standardisation of equipment. Our guidelines were continually evaluated and updated based on emerging evidence. Main outcome measures: Neonatal unit (NNU) admissions, adherence to guidelines and use of glucose gel.ResultsNNU admissions decreased by 70%, from 3% (118/3883) to 0.9% (34/3806 infants). The number requiring an IV glucose bolus reduced from 25% (29/118) to 6% (2/34). Improved antenatal education, antenatal expression of colostrum and early and frequent feeding also contributed to a reduction in glucose gel use of 94% (1009 tubes in 2018‐v‐62 in 2022). There were no adverse side effects related to hypoglycaemia.ConclusionOur QIP resulted in a significant reduction in NNU admissions leading to significant cost reductions and NNU workload. More importantly, this resulted in less maternal–infant separation and potentially less parental anxiety and a more supportive environment for breastfeeding. These low‐cost initiatives can be implemented in other tertiary maternity hospitals to improve maternity and newborn care.
Letter: The importance of histological assessment—a further stride in STRIDE
Authors: Villanacci Vincenzo , Bugatti Mattia , Zini Stefania , Del Sordo Rachele , Bassotti Gabrio 
Published: November 2023

LINKED CONTENTThis article is linked to Dignass et al papers. To view these articles, visit https://doi.org/10.1111/apt.17622 and https://doi.org/10.1111/apt.17763
Letter: The importance of histological assessment—a further stride inSTRIDE. Authors' reply
Authors: Dignass Axel , Rath Stefan , Kleindienst Thomas , Stallmach Andreas 
Published: November 2023

LINKED CONTENTThis article is linked to Dignass et al papers. To view these articles, visithttps://doi.org/10.1111/apt.17622andhttps://doi.org/10.1111/apt.17717
Are opioids effective analgesics and is physiological opioid dependence benign? Revising current assumptions to effectively manage long‐term opioid therapy and its deprescribing
Authors: Manhapra Ajay , MacLean R. Ross , Rosenheck Robert , Becker William C. 
Published: November 2023

AbstractA re‐examination of clinical principles of long‐term opioid therapy (LTOT) for chronic pain is long overdue amid the ongoing opioid crisis. Most patients on LTOT report ineffectiveness (poor pain control, function and health) but still find deprescribing challenging. Although prescribed as analgesics, opioids more likely provide pain relief primarily through reward system actions (enhanced relief and motivation) and placebo effect and less through antinociceptive effects. The unavoidable physiologic LTOT dependence can automatically lead to a paradoxical worsening of pain, disability and medical instability (maladaptive opioid dependence) without addiction due to allostatic opponent neuroadaptations involving reward/antireward and nociceptive/antinociceptive systems. This opioid‐induced chronic pain syndrome (OICP) can persist/progress whether LTOT dose is maintained at the same level, increased, decreased or discontinued. Current conceptualization of LTOT as a straightforward long‐term analgesic therapy appears incongruous in view of the complex mechanisms of opioid action, LTOT dependence and OICP. LTOT can be more appropriately conceptualized as therapeutic induction and maintenance of an adaptive LTOT dependence for functional improvement irrespective of analgesic benefits. Adaptive LTOT dependence should be ideally used for a limited time to achieve maximum functional recovery and deprescribed while maintaining functional gains. Patients on LTOT should be regularly re‐evaluated to identify if maladaptive LTOT dependence with OICP has diminished any functional gains or leads to ineffectiveness. Ineffective LTOT (with maladaptive LTOT dependence) should be modified to make it safer and more effective. An adequately functional life without opioids is the ideal healthy long‐term goal for both LTOT initiation and LTOT modification.
5α‐Tetrahydrocorticosterone: A topical anti‐inflammatory glucocorticoid with an improved therapeutic index in a murine model of dermatitis
Authors: Livingstone Dawn Elizabeth Watson , Sooy Karen , Sykes Catherine , Webster Scott Peter , Walker Brian Robert , Andrew Ruth 
Published: November 2023

AbstractBackground and PurposeGlucocorticoids are powerful anti‐inflammatory drugs, but are associated with many side‐effects. Topical application in atopic dermatitis leads to skin thinning, metabolic changes, and adrenal suppression. 5α‐Tetrahydrocorticosterone (5αTHB) is a potential selective anti‐inflammatory with reduced metabolic effects. Here, the efficacy and side‐effect profile of 5αTHB were compared with hydrocortisone in preclinical models of irritant dermatitis.Experimental ApproachAcute irritant dermatitis was invoked in ear skin of male C57BL/6 mice with a single topical application of croton oil. Inflammation was assessed as oedema via ear weight following treatment with 5αTHB and hydrocortisone. Side‐effects of 5αTHB and hydrocortisone were assessed following chronic topical steroid treatment (28 days) to non‐irritated skin. Skin thinning was quantified longitudinally by caliper measurements and summarily by qPCR for transcripts for genes involved in extracellular matrix homeostasis; systemic effects of topical steroid administration also were assessed. Clearance of 5αTHB and hydrocortisone were measured following intravenous and oral administration.Key Results5αTHB suppressed ear swelling in mice, with ED50 similar to hydrocortisone (23 μg vs. 13 μg). Chronic application of 5αTHB did not cause skin thinning, adrenal atrophy, weight loss, thymic involution, or raised insulin levels, all of which were observed with topical hydrocortisone. Transcripts for genes involved in collagen synthesis and stability were adversely affected by all doses of hydrocortisone, but only by the highest dose of 5αTHB (8× ED50). 5αTHB was rapidly cleared from the systemic circulation.Conclusions and ImplicationsTopical 5αTHB has potential to treat inflammatory skin conditions, particularly in areas of delicate skin.
The Influence of Memory on Visual Perception in Infants, Children, and Adults
Authors: Jaffe‐Dax Sagi , Potter Christine E. , Leung Tiffany S. , Emberson Lauren L. , Lew‐Williams Casey 
Published: November 2023

AbstractPerception is not an independent, in‐the‐moment event. Instead, perceiving involves integrating prior expectations with current observations. How does this ability develop from infancy through adulthood? We examined how prior visual experience shapes visual perception in infants, children, and adults. Using an identical task across age groups, we exposed participants to pairs of colorful stimuli and implicitly measured their ability to discriminate relative saturation levels. Results showed that adult participants were biased by previously experienced exemplars, and exhibited weakened in‐the‐moment discrimination between different levels of saturation. In contrast, infants and children showed less influence of memory in their perception, and they actually outperformed adults in discriminating between current levels of saturation. Our findings suggest that as humans develop, their perception relies more on prior experience and less on current observation.