bluuebunny/crossref_metadata_2025_split huggingface dataset:
White matter microstructure alterations in type 2 diabetes mellitus and its correlation with cerebral small vessel disease and cognitive performance
Authors: Liu Yangyingqiu , Jiang Yuhan , Du Wei , Gao Bingbing , Gao Jie , Hu Shuai , Song Qingwei , Wang Weiwei , Miao Yanwei 
Published: January 2024

AbstractMicrostructural abnormalities of white matter fiber tracts are considered as one of the etiology of diabetes-induced neurological disorders. We explored the cerebral white matter microstructure alteration accurately, and to analyze its correlation between cerebral small vessel disease (CSVD) burden and cognitive performance in type 2 diabetes mellitus (T2DM). The clinical-laboratory data, cognitive scores [including mini-mental state examination (MMSE), Montreal cognitive assessment (MoCA), California verbal learning test (CVLT), and symbol digit modalities test (SDMT)], CSVD burden scores of the T2DM group (n = 34) and healthy control (HC) group (n = 21) were collected prospectively. Automatic fiber quantification (AFQ) was applied to generate bundle profiles along primary white matter fiber tracts. Diffusion tensor images (DTI) metrics and 100 nodes of white matter fiber tracts between groups were compared. Multiple regression analysis was used to analyze the relationship between DTI metrics and cognitive scores and CSVD burden scores. For fiber-wise and node-wise, DTI metrics in some commissural and association fibers were increased in T2DM. Some white matter fiber tracts DTI metrics were independent predictors of cognitive scores and CSVD burden scores. White matter fiber tracts damage in patients with T2DM may be characterized in specific location, especially commissural and association fibers. Aberrational specific white matter fiber tracts are associated with visuospatial function and CSVD burden.
Translational enhancement of target endogenous mRNA in mammalian cells using programmable RNA-binding pentatricopeptide repeat proteins
Authors: Ping Ning , Hara-Kuge Sayuri , Yagi Yusuke , Kazama Tomohiko , Nakamura Takahiro 
Published: January 2024

AbstractProgrammable protein scaffolds are invaluable in the development of genome engineering tools. The pentatricopeptide repeat (PPR) protein is an attractive platform for RNA manipulation because of its programmable RNA-binding selectivity, which is determined by the combination of amino acid species at three specific sites in the PPR motif. Translation is a key RNA regulatory step that determines the final gene expression level and is involved in various human diseases. In this study, designer PPR protein was used to develop a translational enhancement technique by fusion with the translation initiation factor eIF4G. The results showed that the PPR-eIF4G fusion protein could activate the translation of endogenous c-Myc and p53 mRNAs and control cell fate, indicating that PPR-based translational enhancement is a versatile technique applicable to various endogenous mRNAs in mammalian cells. In addition, the translational enhancement was dependent on both the target position and presence of eIF4G, suggesting the presence of an unknown translation activation mechanism.
Parametric investigation of W-EDM factors for machining AM60B conductive biomaterial
Authors: Diviya M. , Joel J. Jebin , Subramanian M. , Balasubramanian T. , Madhusuthan A. V. , Monish N. , Hasan Nasim 
Published: January 2024

AbstractWire—electrical discharge machining (W-EDM) is a precise and efficient non-traditional technology employed to cut intricate shapes in conductive biomaterials. These biomaterials are challenging to machine using traditional methods. This present study delves into the impact of various process parameters, namely discharge duration (Ddur), spark gap time (Stime), discharge voltage (Dvolt), and wire advance rate rate (Wadv). This research evaluates the impact of several factors on response variables, namely the machining rate (MR) and surface irregularity (SR), during the machining process of the AM60B magnesium alloy. The confirmation of the material used in the machining process is achieved via the utilisation of a scanning electron microscopy (SEM) image in conjunction with an energy dispersive spectroscopic (EDS) image. The experiment is designed as L9 orthogonal array by using Taguchi's approach, taking into account 4 factors with 3 levels. The objective of this experiment is to ascertain the most favourable values for machining parameters while working with AM60B magnesium alloy using brass wire. Through analysis of variance (ANOVA), the study confirms that wire advance rate (43.10%) is the most influencing parameter for machining rate and surface irregularity followed by spark gap time (33.91%) and discharge duration (11.48%). Additionally, The TOPSIS-CRITIC and the desirability approach were used in order to determine the optimum parameter combinations that provide the most favourable combined output. Confirmatory testing is used to evaluate the efficiency of the stated ideal conditions. The maximum improvement in Desirability approach is obtained at 4.56% and 4.193% for MR and SR respectively. The maximum improvement in TOPSIS approach is obtained at 1.77% and 2.78% for MR and SR respectively.
High left ventricular mass associated with increased risk of incident diabetes
Authors: Chuang Shih-Ming , Liu Sung-Chen , Leung Ching-Hsiang , Lee Yuan-Teh , Chien Kuo-Liong 
Published: January 2024

AbstractEvidence for the role of electrocardiography or echocardiography in determining left ventricular hypertrophy for the risk of diabetes is still controversial. We aimed to explore whether left ventricular mass, as measured by these methods, is associated with the risk of diabetes in a community population. We recruited 2696 participants aged 35 years or older without diabetes who had undergone screening with electrocardiography and echocardiography. Left ventricular mass index (LVMI) was calculated using a formula, and participants were divided into tertiles based on their LVMI tertiles. During a median follow-up period of median, 8.9 years, a total of 405 participants developed diabetes. The incidence and risk of diabetes significantly increased with higher LVMI tertiles. Multivariate Cox regression analysis demonstrated that individuals in the highest LVMI tertile had a greater likelihood of developing incident diabetes, with a hazard ratio of 1.40 (95% CI 1.06–1.91), even after adjusting related covariates. The highest risk of diabetes was observed in the presence of both the uppermost LVMI tertile and electrocardiographically determined left ventricular hypertrophy for the Chinese population. Left ventricular hypertrophy identified by either electrocardiography or echo may serve as a surrogate marker for identifying the risk of diabetes in clinical practice.
Stochastic lithofacies and petrophysical property modeling for fast history matching in heterogeneous clastic reservoir applications
Authors: Al-Mudhafar Watheq J. , Vo Thanh Hung , Wood David A. , Min Baehyun 
Published: January 2024

AbstractFor complex and multi-layered clastic oil reservoir formations, modeling lithofacies and petrophysical parameters is essential for reservoir characterization, history matching, and uncertainty quantification. This study introduces a real oilfield case study that conducted high-resolution geostatistical modeling of 3D lithofacies and petrophysical properties for rapid and reliable history matching of the Luhais oil reservoir in southern Iraq. For capturing the reservoir's tidal depositional setting using data collected from 47 wells, the lithofacies distribution (sand, shaly sand, and shale) of a 3D geomodel was constructed using sequential indicator simulation (SISIM). Based on the lithofacies modeling results, 50 sets of porosity and permeability distributions were generated using sequential Gaussian simulation (SGSIM) to provide insight into the spatial geological uncertainty and stochastic history matching. For each rock type, distinct variograms were created in the 0° azimuth direction, representing the shoreface line. The standard deviation between every pair of spatial realizations justified the number of variograms employed. An upscaled version of the geomodel, incorporating the lithofacies, permeability, and porosity, was used to construct a reservoir-flow model capable of providing rapid, accurate, and reliable production history matching, including well and field production rates.
Bio-augmentation and bio-stimulation with kenaf core enhanced bacterial enzyme activities during bio-degradation of petroleum hydrocarbon in polluted soil
Authors: Omenna Emmanuel Chukwuma , Omage Kingsley , Ezaka Emmanuel , Azeke Marshall Arebojie 
Published: January 2024

AbstractIndigenous micro-organisms often possess the ability to degrade petroleum hydrocarbon (PHC) in polluted soil. However, this process can be improved by supplementing with nutrients or the addition of more potent microbes. In this study, the ability of kenaf-core to stimulate the PHC degradation capability of microbial isolates from PHC polluted soil samples was evaluated. The standard experimental methods used in this study include: the digestion and analysis of the physico-chemical properties of petroleum hydrocarbon contaminated and non-contaminated soil samples; evaluation of petroleum hydrocarbon biodegradation using bio-augmentation and bio-stimulation (with kenaf-core) treatments; and, determination of soil microbial enzyme activities. Results from this study show that K, Na, total nitrogen, organic carbon, exchangeable cations, and heavy metals were found to be significantly (P < 0.05) higher in the polluted soil than in the non-polluted soil. Also, the polluted samples had pH values ranging from 5.5 to 6.0 while the non-polluted samples had a pH of 7.6. The microbial enzyme activities were comparatively lower in the polluted soils as compared to the non-polluted soil. The percentage degradation in the kenaf-core treated samples (AZ1T2—78.38; BN3T2—70.69; OL1T2—71.06; OT1T2—70.10) were significantly (P < 0.05) higher than those of the untreated (AZ1T1—13.50; BN3T1—12.50; OL1T1—10.55; OT1T1—9.50). The degradation of petroleum hydrocarbon in the bio-augmented and bio-stimulated treatments increased with increasing time of incubation, and were higher than that of the untreated sample. Comparatively, the treatment with a combination of kenaf-core and rhamnolipid exhibited a significantly (P < 0.05) higher degradation rate than that of the treatment with only kenaf core or rhamnolipid. While, the bio-stimulated and bio-augmented treatments had appreciable microbial counts that are higher than that of the untreated. In conclusion, the nutrient-supplement with kenaf-core significantly enhanced microbial growth and activities in the soil, thus improving their ability to biodegrade petroleum hydrocarbons in the polluted soils. Thus, supplementing with Kenaf core to encourage microbiological degradation of petroleum hydrocarbon is recommended.
Enhanced activations in the dorsal inferior frontal gyrus specifying the who, when, and what for successful building of sentence structures in a new language
Authors: Umejima Keita , Flynn Suzanne , Sakai Kuniyoshi L. 
Published: January 2024

AbstractIt has been argued that the principles constraining first language acquisition also constrain second language acquisition; however, neuroscientific evidence for this is scant, and even less for third and subsequent languages. We conducted fMRI experiments to evaluate this claim by focusing on the building of complex sentence structures in Kazakh, a new language for participants having acquired at least two languages. The participants performed grammaticality judgment and subject-verb matching tasks with spoken sentences. We divided the participants into two groups based on the performance levels attained in one of the experimental tasks: High in Group I and Low in Group II. A direct comparison of the two groups, which examined those participants who parsed the structures, indicated significantly stronger activations for Group I in the dorsal left inferior frontal gyrus (L. IFG). Focusing on Group I, we tested the contrast between the initial and final phases in our testing, which examined when the structures were parsed, as well as the contrast which examined what structures were parsed. These analyses further demonstrated focal activations in the dorsal L. IFG alone. Among the individual participants, stronger activation in the dorsal L. IFG, measured during the sentence presentations, predicted higher accuracy rates and shorter response times for executing the tasks that followed. These results cannot be explained by task difficulty or memory loads, and they, instead, indicate a critical and consistent role of the dorsal L. IFG during the initial to intermediate stages of grammar acquisition in a new target language. Such functional specificity of the dorsal L. IFG provides neuroscientific evidence consistent with the claims made by the Cumulative-Enhancement model in investigating language acquisition beyond target second and third languages.
Transcriptomic comparison between populations selected for higher and lower mobility in the red flour beetle Tribolium castaneum
Authors: Matsumura Kentarou , Onuma Takafumi , Kondo Shinji , Noguchi Hideki , Uchiyama Hironobu , Yajima Shunsuke , Sasaki Ken , Miyatake Takahisa 
Published: January 2024

AbstractMovement is an important behavior observed in a wide range of taxa. Previous studies have examined genes controlling movement using wing polymorphic insects and genes controlling wing size. However, few studies have investigated genes controlling movement activity rather than morphological traits. In the present study, we conducted RNA sequencing using populations with higher (WL) and lower (WS) mobility established by artificial selection in the red flour beetle Tribolium castaneum and compared gene expression levels between selected populations with two replicate lines. As a result, we found significant differences between the selected populations in 677 genes expressed in one replicate line and 1198 genes expressed in another replicate line, of which 311 genes were common to the two replicate lines. Furthermore, quantitative PCR focusing on 6 of these genes revealed that neuropeptide F receptor gene (NpF) was significantly more highly expressed in the WL population than in the WS population, which was common to the two replicate lines. We discuss differences in genes controlling movement between walking activity and wing polymorphism.
Association between total cholesterol levels and all-cause mortality among newly diagnosed patients with cancer
Authors: Kim Seohyun , Kim Gyuri , Cho So Hyun , Oh Rosa , Kim Ji Yoon , Lee You-Bin , Jin Sang-Man , Hur Kyu Yeon , Kim Jae Hyeon 
Published: January 2024

AbstractWe aimed to determine the association between cholesterol values and the risk of all-cause mortality in newly diagnosed patients with cancer in a large-scale longitudinal cohort. Newly diagnosed patients with cancer were reviewed retrospectively. Cox proportional hazards regression models determined the association between baseline levels of total cholesterol (TC), triglycerides, high-density lipoprotein (HDL), and low-density lipoprotein (LDL) cholesterol and the risk of all-cause mortality. A restricted cubic spline curve was used to identify the association between total cholesterol (TC) and low-density lipoprotein (LDL) cholesterol with the risk of death on a continuous scale and to present the lowest values of lipid measurements associated with death. The median follow-up duration of the study was 5.77 years. Of the 59,217 patients with cancer, 12,624 patients were expired. The multivariable adjusted hazard ratio (aHR) for all-cause mortality in patients with cancer with 1st–5th (≤ 97 mg/dL) and 96th–100th (> 233 mg/dL) in TC levels was 1.54 (95% CI 1.43–1.66) and 1.28 (95% CI 1.16–1.41), respectively, compared to 61st–80th (172–196 mg/dL). The TC level associated with the lowest mortality risk in the multivariable model was 181 mg/dL. In comparison with LDL-C levels in the 61st–80th (115–136 mg/dL), the multivariable aHR for all-cause mortality in cancer patients with LDL-C levels in the 1st-5th (≤ 57 mg/dL) and 96th–100th (> 167 mg/dL) was 1.38 (95% CI 1.14–1.68) and 0.94 (95% CI 0.69–1.28), respectively. The 142 mg/dL of LDL cholesterol showed the lowest mortality risk. We demonstrated a U-shaped relationship between TC levels at baseline and risk of mortality in newly diagnosed patients with cancer. Low LDL levels corresponded to an increased risk of all-cause death.
Unraveling the impact of microwave-assisted techniques in the fabrication of yttrium-doped TiO2 photocatalyst
Authors: Kubiak Adam , Cegłowski Michał 
Published: January 2024

AbstractIn this study, we investigate the role of microwave technology in the fabrication of yttrium-doped TiO2through a comparative analysis of hydrothermal techniques. Microwave-assisted hydrothermal synthesis offers advantages, but a comprehensive comparison between microwave-assisted and conventional methods is lacking. Therefore, in our investigation, we systematically evaluate and compare the morphological, structural, and optical properties of yttrium-doped TiO2samples synthesized using both techniques. The X-ray diffraction (XRD) patterns confirm the anatase tetragonal structure of the synthesized TiO2-Y systems, while the larger ion radius of yttrium (Y3+) compared to titanium (Ti4+) presents challenges for yttrium to incorporate into the TiO2lattice. The X-ray Photoelectron Spectroscopy (XPS) revealed a significant difference in the atomic content of yttrium between the TiO2-Y systems synthesized using microwave-assisted and conventional methods. This finding suggests that the rapid microwave method is more effective in successfully doping TiO2with rare earth metals such as yttrium. The photo-oxidation of carbamazepine (CBZ) using TiO2-Y systems demonstrated high efficiency under UV-LED light. Microwave-synthesized TiO2-Y demonstrates improved photo-oxidation efficiency of CBZ, attributed to enhanced absorption, charge transfer, surface area, and crystallite size. Overall, the microwave-synthesized TiO2-Y systems showed promising performance for the photo-oxidation of CBZ, with improved efficiency compared to conventional synthesis methods.
Mobile detection of cataracts with an optimised lightweight deep Edge Intelligent technique
Authors: Neogi Dipta , Chowdhury Mahirul Alam , Akter Mst. Moriom , Hossain Md. Ishan Arefin 
Published: January 2024

AbstractTesting the visual field is a valuable diagnostic tool for identifying eye conditions such as cataract, glaucoma, and retinal disease. Its quick and straightforward testing process has become an essential component in our efforts to prevent blindness. Still, the device must be accessible to the general masses. This research has developed a machine learning model that can work with Edge devices like smartphones. As a result, it is opening the opportunity to integrate the disease‐detecting model into multiple Edge devices to automate their operation. The authors intend to use convolutional neural network (CNN) and deep learning to deduce which optimisers have the best results when detecting cataracts from live photos of eyes. This is done by comparing different models and optimisers. Using these methods, a reliable model can be obtained that detects cataracts. The proposed TensorFlow Lite model constructed by combining CNN layers and Adam in this study is called Optimised Light Weight Sequential Deep Learning Model (SDLM). SDLM is trained using a smaller number of CNN layers and parameters, which gives SDLM its compatibility, fast execution time, and low memory requirements. The proposed Android app, I‐Scan, uses SDLM in the form of TensorFlow Lite for demonstration of the model in Edge devices.
Wie wirksam ist die osteopathische Behandlung von
Kindern?
Authors: Engemann Katharina 
Published: January 2024

Franke H, Franke J-D, Fryer G. Effectiveness of osteopathic manipulative treatment
for pediatric conditions: A systematic review. Journal of Bodywork Movement
Therapies 2022; 31: 113–133Franke H, Franke J-D, Fryer G. Wirksamkeit der osteopathischen Behandlung bei
pädiatrischen Beschwerden: Eine systematische Übersichtsarbeit.
Osteopathische Medizin 2022; 23 (4): 4–13
Reproductive health among women living with HIV attending Melbourne Sexual Health Centre for HIV care from February 2019 to February 2020
Authors: Peel Joanne , Brousse de Gersigny Joshua , Teague Richard , Howard Jayne , Bradshaw Catriona , Chen Marcus , Bissessor Melanie 
Published: January 2024

Background Women living with HIV are a minority population with unique care needs. Rates of unintended pregnancy are higher among women living with HIV versus HIV negative women. However, uptake of contraception among women living with HIV including long-acting-reversible contraceptives (LARCs) remains low. This quality improvement project aimed to identify gaps in reproductive healthcare for women living with HIV attending Melbourne Sexual Health Centre (MSHC). Methods We performed a retrospective review of women living with HIV attending MSHC for HIV care February 2019–February 2020. Women aged over 45 years were excluded. Primary outcomes included proportion using contraception, methods used and whether a sexual or reproductive health history had been taken in the past year. Results A total of 100 women were included, predominantly born overseas (Asia, 38%; sub-Saharan Africa, 34%). Of these, 5% were pregnant, 16% were trying to conceive and 1% were undergoing elective oocyte preservation. Of the remaining 74 women, 48.6% were using any form of contraception, including 17.6% women using less-effective methods (withdrawal and condoms), 6.8% using the combined oral contraceptive pill, 18.9% using LARCs and 5.4% using permanent methods. Sexual activity status was documented for 61% women, 1% declined to answer and not documented for 38% women. Conclusions Rate of contraceptive use in this study was lower than previously reported among women living with HIV in Australia; however, our findings suggest contraceptive methods may be changing in light of undetectable equals untransmittable and increased fertility desires. Discussions regarding sexual activity and reproductive health were limited. Mechanisms to increase clinician–patient discourse regarding these important issues should be explored.
Revisiting the island of hexadecapole-deformation nuclei in the A ≈ 150 mass region: focusing on the model application to nuclear shapes and masses
Authors: Wei Xiao-Yang , Wang Hua-Lei , Zhang Zhen-Zhen , Liu Min-Liang 
Published: January 2024

Abstract
Based on the potential-energy-surface calculation, the impact of different deformation degrees of freedom on a single-particle structure and binding energies in nuclei around 152Nd, located on one of the hexadecapole-deformation islands, is analyzed in a multi-dimensional deformation space. Various energy maps, curves and tables are presented to indicate nuclear properties. The calculated equilibrium deformations and binding energies with different potential parameters are compared with experimental data and other theories. It is found that the inclusion of the hexadecapole deformations, especially the axial one, can improve the theoretical description of both nuclear shapes and masses. In addition, our calculated potential-energy curve shows that a critical deformation-point, β
2 ≈ 0.4, exists—the triaxial (hexadecapole) deformation effect can be neglectable but the hexadecapole (triaxial) one plays an important role before (after) such a critical point.