bluuebunny/crossref_metadata_2025_split huggingface dataset:
Multi‐attribute temporal descriptive methods in sensory analysis applied in food science: A systematic scoping review
Authors: Visalli Michel , Galmarini Mara Virginia 
Published: January 2024

AbstractAmong descriptive sensory evaluation methods, temporal methods have a wide audience in food science because they make it possible to follow perception as close as possible to the moment when sensations are perceived. The aim of this work was to describe 30 years of research involving temporal methods by mapping the scientific literature using a systematic scoping review. Thus, 363 research articles found from a search in Scopus and Web of Science from 1991 to 2022 were included. The extracted data included information on the implementation of studies referring to the use of temporal methods (details related to subjects, products, descriptors, research design, data analysis, etc.), reasons why they were used and the conclusions they allowed to be drawn. Metadata analysis and critical appraisal were also carried out. A quantitative and qualitative synthesis of the results allowed the identification of trends in the way in which the methods were developed, refined, and disseminated. Overall, a large heterogeneity was noted in the way in which the temporal measurements were carried out and the results presented. Some critical research gaps in establishing the validity and reliability of temporal methods have also been identified. They were mostly related to the details of implementation of the methods (e.g., almost no justification for the number of consumers included in the studies, absence of report on panel repeatability) and data analysis (e.g., prevalence of use of exploratory data analysis, only 20% of studies using confirmatory analyses considering the dynamic nature of the data). These results suggest the need for general guidelines on how to implement the method, analyze and interpret data, and report the results. Thus, a template and checklist for reporting data and results were proposed to help increase the quality of future research.
Assessment of oral methotrexate intolerance in Japanese adult patients with rheumatoid arthritis
Authors: Kanda Masatoshi , Sato Mayumi , Nagahata Ken , Naishiro Yasuyoshi , Murakami Rieko , Honda Saho , Suzuki Chisako 
Published: January 2024

AbstractAimThe objective of this study was to assess the gastrointestinal side (GI) effects of oral methotrexate (MTX) in Japanese adult patients with rheumatoid arthritis (RA).MethodsIn this single‐center retrospective study, 112 Japanese adult patients (over 18 years old) with RA were examined by Methotrexate Intolerance and Severity assessment in Adults (MISA) questionnaire.ResultsForty‐five (40.2%) of patients were MTX intolerant (MISA score ≥1). Twelve patients (11.2%) were moderate‐to‐severe MTX intolerant (MISA cross‐product score ≥4). The most common GI side effects of MTX were gastric discomfort (26.8%), followed by loss of appetite or dysgeusia (14.3%), fatigue and lethargy (12.5%), and nausea (10.7%).ConclusionsJapanese adult patients with RA showed a high prevalence of MTX intolerance even in low‐dose oral MTX. The MISA questionnaire was practical for finding patients with MTX intolerance.
AllergoOncology: Biomarkers and refined classification for research in the allergy and glioma nexus—A joint EAACI‐EANO position paper
Authors: Turner Michelle C. , Radzikowska Urszula , Ferastraoaru Denisa E. , Pascal Mariona , Wesseling Pieter , McCraw Alexandra , Backes Claudine , Bax Heather J. , Bergmann Christoph , Bianchini Rodolfo , Cari Luigi , de las Vecillas Leticia , Izquierdo Elena , Lind‐Holm Mogensen Frida , Michelucci Alessandro , Nazarov Petr V. , Niclou Simone P. , Nocentini Giuseppe , Ollert Markus , Preusser Matthias , Rohr‐Udilova Nataliya , Scafidi Andrea , Toth Reka , Van Hemelrijck Mieke , Weller Michael , Jappe Uta , Escribese Maria M. , Jensen‐Jarolim Erika , Karagiannis Sophia N. , Poli Aurélie 
Published: January 2024

AbstractEpidemiological studies have explored the relationship between allergic diseases and cancer risk or prognosis in AllergoOncology. Some studies suggest an inverse association, but uncertainties remain, including in IgE‐mediated diseases and glioma. Allergic disease stems from a Th2‐biased immune response to allergens in predisposed atopic individuals. Allergic disorders vary in phenotype, genotype and endotype, affecting their pathophysiology. Beyond clinical manifestation and commonly used clinical markers, there is ongoing research to identify novel biomarkers for allergy diagnosis, monitoring, severity assessment and treatment. Gliomas, the most common and diverse brain tumours, have in parallel undergone changes in classification over time, with specific molecular biomarkers defining glioma subtypes. Gliomas exhibit a complex tumour‐immune interphase and distinct immune microenvironment features. Immunotherapy and targeted therapy hold promise for primary brain tumour treatment, but require more specific and effective approaches. Animal studies indicate allergic airway inflammation may delay glioma progression. This collaborative European Academy of Allergy and Clinical Immunology (EAACI) and European Association of Neuro‐Oncology (EANO) Position Paper summarizes recent advances and emerging biomarkers for refined allergy and adult‐type diffuse glioma classification to inform future epidemiological and clinical studies. Future research is needed to enhance our understanding of immune–glioma interactions to ultimately improve patient prognosis and survival.
Impact of climate change on atopic dermatitis: A review by the International Eczema Council
Authors: Wang Sheng‐Pei , Stefanovic Nicholas , Orfali Raquel L. , Aoki Valeria , Brown Sara J. , Dhar Sandipan , Eichenfield Lawrence F. , Flohr Carsten , Ha Alex , Mora Camilo , Murase Jenny E. , Rosenbach Misha , Srinivas Sahana M. , Thyssen Jacob P. , Wei Maria L. , Irvine Alan D. , Abuabara Katrina 
Published: January 2024

AbstractAtopic dermatitis (AD), the most burdensome skin condition worldwide, is influenced by climatic factors and air pollution; however, the impact of increasing climatic hazards on AD remains poorly characterized. Leveraging an existing framework for 10 climatic hazards related to greenhouse gas emissions, we identified 18 studies with evidence for an impact on AD through a systematic search. Most climatic hazards had evidence for aggravation of AD the impact ranged from direct effects like particulate matter‐induced AD exacerbations from wildfires to the potential for indirect effects like drought‐induced food insecurity and migration. We then created maps comparing the past, present, and future projected burden of climatic hazards to global AD prevalence data. Data are lacking, especially from those regions most likely to experience more climatic hazards. We highlight gaps important for future research: understanding the synergistic impacts of climatic hazards on AD, long‐term disease activity, the differential impact on vulnerable populations, and how basic mechanisms explain population‐level trends.
Maternal singing reduced pain indexes in 2‐month‐old infants and increased proximity during vaccinations
Authors: Monaci Maria Grazia , Caruzzo Chiara Maria , Raso Romina , Spagnuolo Carmen , Benedetti Maria Clorinda , Grandjean Didier , Filippa Manuela 
Published: January 2024

AbstractAimImmunisation is a global health priority, but methods of non‐pharmacological pain relief are not widely used in routine clinical practice. In this study, we set out to investigate the effects of maternal singing during the routine vaccination of infants.MethodsWe recruited 67 mother–infant pairs at Health Centres in the Aosta Region of Italy. Infants aged 2–4 months were randomly allocated to a singing intervention group or to a control group whose injections were administered following standard practice. Pre‐ and post‐immunisation pain was blindly assessed using the Modified Behavioural Pain Scale, and mother–infant proximity indexes were assigned based on muted video‐tracks.ResultsWhen assessed for pain, the infants in the maternal singing group were assigned significantly lower movement indexes (p = 0.032) and marginally significantly lower cry indexes (p = 0.076). A higher frequency of mother‐to‐infant gaze (p < 0.005) was observed in the singing group dyads. Finally, the intervention group mothers' self‐perceived ease in singing was correlated with their previous singing experience and with lower anxiety following the vaccination procedure (p < 0.05).ConclusionMaternal singing during immunisation procedures benefits both mothers and babies. The practice of singing is a biologically rooted and adaptive form of intuitive parental communication that should be encouraged, especially in at‐risk populations.
Identification and analysis of gemstone binding materials on imperial rank belts excavated from the tomb of Murongzhi
Authors: Liang Yun , Chen Guoke , Liu Bingbing , Yu Chun , Xian Yiheng 
Published: January 2024

AbstractThis paper analyzes and identifies the binders used in the jewel settings of the Baodian and Diexie belts excavated from the tomb of Murongzhi in Wuwei, Gansu, China. Fourier transform infrared spectroscopy (FTIR) indicated the presence of protein in the binder samples. The result of gas chromatography–mass spectrometry (GC‐MS) shows that samples from both contained hydroxyproline, a characteristic amino acid for animal glue. Principal component analysis was performed on one of the samples, and it was concluded that the binder was a mixture of hide glue and egg glue. Further analysis using scanning electron microscopy with energy‐dispersive X‐ray (SEM‐EDX) and laser Raman spectroscopy (Raman) found that a red particulate matter visually identified in the binder was cinnabar, which was apparently added to binder in order to modify the color of the jewels. This study provides a basis for the conservation and restoration of future finds of elite jewelry. It also shows how imperial jewelry was made during the Tang Dynasty. Finally, the analysis of these heraldic belts provides a key insight the life and role of an exiled prince in the Tang court.
Identifiability and estimability of Bayesian linear and nonlinear crossed random effects models
Authors: Rohloff Corissa T. , Kohli Nidhi , Lock Eric F. 
Published: January 2024

AbstractCrossed random effects models (CREMs) are particularly useful in longitudinal data applications because they allow researchers to account for the impact of dynamic group membership on individual outcomes. However, no research has determined what data conditions need to be met to sufficiently identify these models, especially the group effects, in a longitudinal context. This is a significant gap in the current literature as future applications to real data may need to consider these conditions to yield accurate and precise model parameter estimates, specifically for the group effects on individual outcomes. Furthermore, there are no existing CREMs that can model intrinsically nonlinear growth. The goals of this study are to develop a Bayesian piecewise CREM to model intrinsically nonlinear growth and evaluate what data conditions are necessary to empirically identify both intrinsically linear and nonlinear longitudinal CREMs. This study includes an applied example that utilizes the piecewise CREM with real data and three simulation studies to assess the data conditions necessary to estimate linear, quadratic, and piecewise CREMs. Results show that the number of repeated measurements collected on groups impacts the ability to recover the group effects. Additionally, functional form complexity impacted data collection requirements for estimating longitudinal CREMs.
Japanese Society of Medical Oncology clinical guidelines: Molecular testing for colorectal cancer treatment, 5th edition
Authors: Bando Hideaki , Yamaguchi Kyoko , Mitani Seiichiro , Sawada Kentaro , Mishima Saori , Komine Keigo , Okugawa Yoshinaga , Hosoda Waki , Ebi Hiromichi 
Published: January 2024

AbstractMolecular testing to determine optimal therapies is essential for managing patients with colorectal cancer (CRC). In October 2022, the Japanese Society of Medical Oncology published the 5th edition of the Molecular Testing Guideline for Colorectal Cancer Treatment. In this guideline, in patients with unresectable CRC, RAS/BRAF V600E mutational and mismatch repair tests are strongly recommended prior to first‐line chemotherapy to select optimal first‐ and second‐line therapies. In addition, HER2 testing is strongly recommended because the pertuzumab plus trastuzumab combination is insured after fluoropyrimidine, oxaliplatin, and irinotecan in Japan. Circulating tumor DNA (ctDNA)‐based RAS testing is also strongly recommended to assess the indications for the readministration of anti‐EGFR antibodies. Both tissue‐ and ctDNA‐based comprehensive genomic profiling tests are strongly recommended to assess the indications for targeted molecular drugs, although they are currently insured in patients with disease progression after receiving standard chemotherapy (or in whom disease progression is expected in the near future). Mutational and mismatch repair testing is strongly recommended for patients with resectable CRC, and RAS/BRAF V600E mutation testing is recommended to estimate the risk of recurrence. Mutational and mismatch repair and BRAF testing are also strongly recommended for screening for Lynch syndrome. Circulating tumor DNA‐based minimal residual disease (MRD) testing is strongly recommended for estimating the risk of recurrence based on clinical evidence, although MRD testing was not approved in Japan at the time of the publication of this guideline.
The colon does not reach! A technical note with tricks to avoid colorectal anastomoses under tension
Authors: Dalmau Mar , Marti‐Gallostra Marc , Pellino Gianluca , Espin‐Basany Eloy , Armengol Manuel 
Published: January 2024

AbstractAimWe describe two options for colorectal anastomosis suitable in cases when the colon would reach the pelvis under tension.MethodDeloyers procedure and the retro‐ileal colorectal anastomosis are presented, focusing on practical tips and tricks to perform them. Insights on patients who underwent the procedures are provided to demonstrate the advantages and feasibility of the techniques.ResultsEach step of both techniques is detailed. Ten patients underwent Deloyers procedure and nine underwent retro‐ileal anastomosis at our unit. A minimally invasive approach was attempted in 13 patients, of whom five required conversion to open surgery due to the technical complexity of the abdominal procedure. Colorectal anastomosis was successfully performed in all patients. There were no major intra‐operative complications, although five patients had postoperative complications requiring further treatment.ConclusionsBoth techniques are effective in patients at risk of receiving a colorectal anastomosis under tension, and a minimally invasive approach can be used. However, owing to the complexity of surgery in this group of patients, the perioperative morbidity is not negligible. Careful postoperative management is advisable, and patients should be informed of the risks. In expert hands, the outcomes are acceptable, avoiding an ileorectal anastomosis and its constraints.
The influence of socioeconomic deprivation on outcomes in transplant patients infected with SARS‐CoV‐2 in Wales
Authors: Koimtzis Georgios , Geropoulos Georgios , Chalklin Christopher , Karniadakis Ioannis , Szabo Laszlo , Ilham Mohammed Adel , Stephens Michael , Asderakis Argiris , Khalid Usman 
Published: January 2024

AbstractIntroductionSARS‐CoV‐2 infection has had a significant impact on vulnerable individuals including transplant patients. Socioeconomic deprivation negatively affects outcomes of many health conditions. The aim of this study was to evaluate the effect of socioeconomic deprivation on the incidence and severity of SARS‐CoV‐2 infection among Welsh transplant patients.MethodsThis study is a retrospective, cross‐sectional study on the transplant population of Wales. The Welsh Index of Multiple Deprivation (WIMD) was used to assess the influence of socioeconomic deprivation on outcomes of Welsh transplant patients who developed SARS‐CoV‐2 infection. Outcome measures were the incidence of SARS‐CoV‐2 infection, rates of hospital and ICU admission, development of acute kidney injury (AKI) and mortality. A logistic binomial regression analysis was used to correlate the various risk factors with the incidence of SARS‐CoV‐2 infection.ResultsTwo hundred and sixty‐six (25%) of regular follow up patients had SARS‐CoV‐2 infection; of these 55 (20.7%) were admitted, 15 (5.6%) to ICU, 37 (13.9%) developed AKI, and 23 (8.6%) died. In a regression analysis, patients of younger age were associated with more (p = .001) and those with SPK (simultaneous pancreas kidney) transplant less chance of infection (p = .038), whereas social deprivation was not associated with the chance of infection (p = .14). In regression analysis increased social deprivation was associated with higher chance of AKI post SARS‐CoV‐2 (p = .049).ConclusionsSocioeconomic deprivation did not affect the rates or severity of SARS‐CoV‐2 infection apart from the degree of AKI in Welsh Transplant patients. Adherence to the preventive measures for this high‐risk population must continue to remain a priority.
Risk factors for cerebral palsy in children in Taiwan
Authors: Chen Yuping , Huang Jing‐Yang , Wei James Cheng‐Chung , Lee Shih‐Yu , Huang Ya‐Fang 
Published: January 2024

AbstractAimTo determine the significant risk factors of cerebral palsy (CP) in Taiwanese children and the associations between infant‐related and parent‐related factors.MethodData from 1 459 093 infants and their parents in Taiwan's national databases collected between 2009 and 2016 were used. The cohort with CP included children diagnosed with CP between birth and age 3 years; a total of 3254 children with CP were included in the final analysis. Hierarchical logistic regression models were used to estimate the odds ratio for the risk factors of CP.ResultsThe hierarchical logistic regression models indicated that significant risk factors associated with CP are suburban location, low income, maternal and paternal diabetes mellitus, paternal substance abuse, paternal seizure disorder, male sex, birth by Cesarean section, singleton birth, low birthweight, being born extremely and very preterm, intraventricular hemorrhage, and periventricular leukomalacia, as well as tube feeding, ventilator use, and dopamine administration within 6 months of age.InterpretationIn addition to common maternal and infant risk factors, we identified significant paternal risk factors associated with CP, including diabetes mellitus, seizure disorder, and substance abuse. The combination of maternal, paternal, and infant risk factors in CP holds great promise for early identification and intervention.
Postprandial glucose‐management strategies in type 1 diabetes: Current approaches and prospects with precision medicine and artificial intelligence
Authors: Jafar Adnan , Pasqua Melissa‐Rosina 
Published: January 2024

AbstractPostprandial glucose control can be challenging for individuals with type 1 diabetes, and this can be attributed to many factors, including suboptimal therapy parameters (carbohydrate ratios, correction factors, basal doses) because of physiological changes, meal macronutrients and engagement in postprandial physical activity. This narrative review aims to examine the current postprandial glucose‐management strategies tested in clinical trials, including adjusting therapy settings, bolusing for meal macronutrients, adjusting pre‐exercise and postexercise meal boluses for postprandial physical activity, and other therapeutic options, for individuals on open‐loop and closed‐loop therapies. Then we discuss their challenges and future avenues. Despite advancements in insulin delivery devices such as closed‐loop systems and decision‐support systems, many individuals with type 1 diabetes still struggle to manage their glucose levels. The main challenge is the lack of personalized recommendations, causing suboptimal postprandial glucose control. We suggest that postprandial glucose control can be improved by (i) providing personalized recommendations for meal macronutrients and postprandial activity; (ii) including behavioural recommendations; (iii) using other personalized therapeutic approaches (e.g. glucagon‐like peptide‐1 receptor agonists, sodium‐glucose co‐transporter inhibitors, amylin analogues, inhaled insulin) in addition to insulin therapy; and (iv) integrating an interpretability report to explain to individuals about changes in treatment therapy and behavioural recommendations. In addition, we suggest a future avenue to implement precision recommendations for individuals with type 1 diabetes utilizing the potential of deep reinforcement learning and foundation models (such as GPT and BERT), employing different modalities of data including diabetes‐related and external background factors (i.e. behavioural, environmental, biological and abnormal events).
Multi‐modality imaging of the systemic right ventricle in congenital heart disease
Authors: Baroutidou Amalia , Ntiloudi Despoina , Kasinos Nearchos , Nyktari Evangelia , Giannakoulas George 
Published: January 2024

AbstractA comprehensive and structured imaging approach in the evaluation of the systemic right ventricle (sRV) in patients with complete transposition of the great arteries (TGA) after atrial switch procedure and congenitally corrected transposition of the great arteries (ccTGA) is a key for their optimal lifelong surveillance. Despite the improvements in cardiovascular imaging of adults with congenital heart disease (ACHD), the imaging of sRV remains an ongoing challenge due to its complex morphology and the difficulty in applying the existing knowledge for the systemic left ventricle. While cardiac magnetic resonance (CMR) is considered the gold standard imaging method, echocardiographic evaluation is primarily preferred in everyday clinical setting. Although qualitative assessment of its systolic function is primarily used, the introduction of advanced echocardiographic techniques, such as speckle tracking echocardiography (STE) and three‐dimensional echocardiography (3DE), has provided new insights into the optimal assessment of the sRV. Standardized quantitative parameters remain to be elucidated, and morphometric and mechanistic studies are warranted to validate reference ranges for the sRV. This review highlights the challenges in the optimal evaluation of sRV and summarizes the available imaging tools.Highlights
CMR is the gold standard imaging method of sRV.
Qualitative assessment of the systolic function of sRV is primarily used.
Advanced echocardiographic techniques (STE and 3DE) provide optimal sRV assessment.
Reference ranges for the sRV indices are warranted to be validated.