bluuebunny/crossref_metadata_2025_split huggingface dataset:
Effects of Thienopyridine Class Antiplatelets on Bleeding Outcomes Following Robot-Assisted Radical Prostatectomy
Authors: Kubota Masashi , Kawakita Mutsushi , Yoshida Satomi , Kimura Hiroko , Sumiyoshi Takayuki , Yamasaki Toshinari , Okumura Kazuhiro , Yoshimura Koji , Matsui Yoshiyuki , Sugiyama Kyohei , Okuno Hiroshi , Segawa Takehiko , Shimizu Yosuke , Ito Noriyuki , Onishi Hiroyuki , Ishitoya Satoshi , Soda Takeshi , Yoshida Toru , Uemura Yuichi , Iwamura Hiroshi , Okubo Kazutoshi , Suzuki Ryosuke , Fukuzawa Shigeki , Akao Toshiya , Kurahashi Ryoma , Shimatani Kimihiro , Sekine Yuya , Negoro Hiromitsu , Akamatsu Shusuke , Kamoto Toshiyuki , Ogawa Osamu , Kawakami Koji , Kobayashi Takashi , Goto Takayuki 
Published: November 2023

Abstract
This study aimed to assess the effects of thienopyridine-class antiplatelet agents (including ticlopidine, clopidogrel, and prasugrel) on bleeding complications in patients who underwent robot-assisted radical prostatectomy. This cohort study used a database for robot-assisted radical prostatectomy at 23 tertiary centers nationwide between 2011 and 2022. Patients who received thienopyridines (thienopyridine group) were compared with those who received aspirin monotherapy (aspirin group). The primary outcome was the incidence of bleeding complications. High-grade complications were defined as Clavien–Dindo grade III or higher. The risks of these outcomes were evaluated using inverse probability of treatment weighted regression models. The study results demonstrated that thienopyridine therapy was associated with a higher risk of overall bleeding complications (OR:3.62, 95%CI:1.54–8.49). The increased risks of the thienopyridine group were detected for low-grade bleeding complications (OR:3.20, 95%CI:1.23–8.30) but not for high-grade bleeding complications (OR:5.23, 95%CI:0.78–34.9). The increased risk of bleeding complications was not observed when thienopyridine was discontinued (OR:2.52, 95%CI:0.83–7.70); however, it became apparent when it was continued perioperatively (OR:4.35, 95%CI:1.14–16.61). In conclusion, thienopyridine increased the incidence of bleeding complications, particularly low-grade bleeding complications, following robot-assisted radical prostatectomy. These bleeding effects emerged when thienopyridine was continued perioperatively.
General practitioners' knowledge of psychotrauma in Burkina Faso in a context of security challenges
Authors: SAWADOGO Konsam Cédric Christel , BAGUE Boubacar , Adama GALBONI , ABDOU Mahamane Mobarak SALIFOU , CISSE Zeinabou , KARFO Kapouné 
Published: November 2023

Abstract
Post-traumatic stress disorders are psychiatric disorders that arise after a traumatic event. They result in moral suffering and physical complications that profoundly alter personal, social and professional life. Our main objective was to study general practitioners' knowledge of psychotrauma.
This was a descriptive, cross-sectional study whose data collection took place from January 15 to September 15, 2023 in Burkina Faso. General practitioners practicing in Burkina Faso were included. The minimum number of subjects to be included was 422. A Google Form ® questionnaire was administered to participants.
Our study sample comprised 427 general practitioners, 67% of whom were men (284/427). The mean age of the doctors was 32.4 ± 3.5 years. Doctors were married in 49% of cases (208/427) and single in 41% (174/427). Average professional experience was 3.8±2.6 years. The largest number of GPs (120) came from the Centre region. A minority of GPs practiced in rural areas (7%). The majority of GPs (63%) thought they had already dealt with a case of psychotrauma. Our sample had received training in psychotrauma during their medical studies in 26.9% of cases, and 17.8% had received continuing education. Considering the grading of GPs' knowledge of psychotrauma, 182 had an average score of 10 or above, i.e. 43% of our sample. Our study did not reveal any factors associated with better knowledge of psychotrauma.
A study on a larger population including nurses could enable us to better assess the level of knowledge in pychotrauma.
Maybe a New Target for Gli̇omas: AQP1
Authors: Ozturk Saniye Elvan 
Published: November 2023

Abstract
Backround:
Gliomas, which are the most common tumors of the central nervous system, are also among the most aggressive tumors. Despite the studies, the prognosis of gliomas is poor. Therefore, studies that will form the basis for the diagnosis and treatment of the disease are very important for these patient groups. In this study, the course of members of the Aquaporin family in gliomas was examined, and among these, the relationship of AQP1 and AQP4 with gliomas was investigated.
Methods and Results:
In this study conducted using in silico methods, the expression levels of the AQP family in LGG and GBM-type gliomas were compared. As a result of the findings obtained here, the prognostic value and clinical importance of AQP1 and AQP4 were evaluated. For this purpose, GEPIA, UCSC Xena, Gliovis, cBioPortal, and Ivy GAP analysis tools were used.
According to the data obtained at the end of the study, AQP1 and AQP4 gene expressions were found to be more expressed in tumor tissue than in normal tissue in the LGG and GBM datasets. Thereupon, the effects of these two genes on the survival and prognosis of patients were investigated using the expression patterns in the LGG and GBM datasets. When the expression levels of these two genes were compared in the subtypes, it was found that AQP1 was low in the Oligodendrogram subtype of LGG, and both AQP1 and AQP4 levels were high in all the remaining subtypes.
Conclusions:
Within the framework of the findings, it can be said that not only AQP4 but also AQP1 from the aquaporin family is one of the genes effective in the pathogenesis of gliomas and patient survival. AQP1 may be used as a new drug target or biomarker against aggressive gliomas. Therefore, it should be evaluated for future studies.
Optimizing Bank Loan Approval with Cutting-Edge DeepLearning model
Authors: Mahgoub Abdalla 
Published: November 2023

Abstract
For any bank or financial institution, managing loans and controlling leverage is one of the mostimportant tasks they have to undertake. A bank cannot function efficiently without a welldesignedloan-to-deposit business model.
As technology continues to evolve, the mechanism ofhandling and granting loans underwent a significant change with the introduction of use cases concerning machine learning and data science.Hence, this data-driven research utilized advanced machine learning techniques to analyze andmanipulate the data, aiming to predict the best possible way to recommend a loan to a client.
These predictions are based on modified yet unique features created from the data obtained fromthe client. The dataset was tested using two different methodologies: a logistic regression modeland a Neural Network algorithm. Both of these methodologies produced high-level accuracyrates. However, the latter outperformed the currently used methodologies by over 20%, resultingin an accuracy of 90%.
The successful research results were obtained due to the use of a perfectly balanced, unbiased,and cleaned dataset, as well as the well-executed combination of activation functions for theNeural Network model. A performance assessment was conducted based on a confusion matrixevaluation to demonstrate its feasibility and performance.
A metachronous bilateral upper urinary tract urothelial carcinoma achieved partial remission by multiple treatment modalities: A case report and literature review
Authors: Tian Hongzhe , Liu Wei , Yang Jiarong , Yan Chunhui , Hu Qintao , Huang Haohao , Pan Tiejun 
Published: November 2023

Abstract
Background: Upper tract urothelial carcinoma (UTUC) is less common but more aggressive than bladder urothelial carcinoma in China. Bilateral UTUC is even rarer. Managing bilateral UTUC is a great challenge, especially when patients request kidney sparing and refuse hemodialysis. Besides robot-assisted laparoscopic radical nephroureterectomy (RNU) and chemotherapy, immune checkpoint inhibitor therapy is a promising strategy. We present a case of metachronous bilateral UTUC that benefited from multiple treatment modalities.
Case Description: We report a special case of a 68-year-old woman with metachronous bilateral UTUC. She underwent robot-assisted laparoscopic radical nephroureterectomy (RNU) due to an occupied lesion in the middle segment of the right ureter. Pathological findings indicated muscle-invasive high-grade urothelial carcinoma (on the right), clinical stage T3N1M0, high-risk. Adjuvant gemcitabine/cisplatin chemotherapy for three cycles every 21 days was administered. To prevent tumor recurrence in bladder, sapylin (OK-432) was used for intravesical instillation, made from a low-virulence strain (Su) of Streptococcus pyogenes (group A) incubated with penicillin. Twenty-nine months later, a left renal pelvis-occupied lesion was found. Pathological examination by ureteroscopy suggested that the tumor was non-invasive high-grade papillary urothelial carcinoma. The patient requested kidney sparing and declined radical surgery. The tumor was too large for complete endoscopic resection. The patient underwent neoadjuvant chemoimmunotherapy followed by retrograde intrarenal surgery (RIRS). After surgery, adjuvant immunotherapy was continued as before. The patient finally achieved partial remission.
Conclusions: We present a rare case of metachronous bilateral UTUC. The patient had radical surgery for the right UTUC and requested kidney sparing for the subsequent left UTUC. The patient received neoadjuvant chemoimmunotherapy followed by RIRS and adjuvant immunotherapy for the left UTUC. The patient achieved a stable state with no disease progression and partial remission of the left UTUC. Our report suggests a new approach for the treatment of bilateral UTUC.
Tissue-Engineered Bone Construct Promotes Early Osseointegration of Implants with Low Primary Stability in oversized osteotomy
Authors: Xu Lianyi , Jacobs Reinhilde , Cao Yingguang , Sun Xiaojuan , Qin Xu 
Published: November 2023

Abstract
Objectives
To evaluate the histological parameters and bone mechanical properties around implants with low primary stability (PS) in grafted bone substitutes within an oversized osteotomy.
Materials and Methods
An oversized osteotomy penetrating the double cortical bone layers was made on both femora of 24 New Zealand white rabbits. Bilaterally in the femur of all animals, 48 implants were installed, subdivided into four groups, corresponding to four prepared tissue-engineered bone grafts (TEBGs), which were placed between the implant surface and native bone wall: A: tricalcium phosphate β (TCP-β); B: autologous adipose derived-stem cells with TCP-β (ASCs/TCP-β); C: ASCs transfected with the enhanced-GFP gene with TCP-β (EGFP-ASCs/TCP-β); D: ASCs transfected with the BMP-2 gene with TCP-β (BMP2-ASCs/TCP-β). Trichrome fluorescent labeling was conducted. Animals were sacrificed after eight weeks. The trichromatic fluorescent labeling (%TFL), area of new bone (%NB), residual material (%RM), bone-implant contact (%BIC), and the removal torque force (RTF, N/cm) were assessed.
Results
The BMP-2 overexpression of ASCs sustained for ten days and greatly enhanced osteogenic differentiation. At eight weeks post-implantation, increased %NB and RTF were found in all groups. The most significant value of %TFL, %BIC and lowest %RM was detected in group D.
Conclusion
The low PS implants osseointegrate with considerable new bone in TEBGs peri-stuffed site. The addition of ASCs and BMP-2 further stimulated the %BIC. Bone graft offers wedging effect for the implant with low PS at placement and promotes osteogenesis on their surface in the healing period.
New adsorbent for detoxification of hemicellulose-rich hydrolysate aiming xylitol production
Authors: Dussán Kelly J. , Silva Débora D. V. , Costa Isabela A. L. , Forte Marcus B. S. , Felipe Maria G. A. 
Published: November 2023

Abstract
The world demand for sustainable bioprocesses is unquestionable as for researches which aims the biotechnological exploitation of lignocellulosic materials, particularly of its hemicellulosic fractions rich in xylose. Different bioproducts can be obtained from those fractions, although, some bottlenecks still exist such as the presence in the hemicellulosic hydrolysates of toxic compounds for microorganisms which requires previous step of detoxification. Hydrotalcite is used as a new detoxifying agent of the hemicellulosic hydrolysate of sugar cane straw to produce xylitol by Candida tropicalis aiming at a greater removal of phenolics and less loss of sugars. Design of experiments was used for factors effects analysis by a simultaneous way; the influences of pH and temperature were evaluated considering the detoxification process in different times for both uncalcinated and calcinated hydrotalcites adsorbents. While for the calcined hydrotalcite, the temperature was the significant factor, and for the non-calcined there was also an influence of the pH. The hydrotalcite reduced the content of phenolic compounds in the hydrolysate with low loss in sugar content and in xylitol production. Those results suggest new investigations for the proposition of this new adsorbent in search for the development of technologies for obtaining bioproducts in a biorefinery context.
Vaccination protects against acute respiratory distress syndrome (ARDS) in hospitalized patients with COVID-19
Authors: Madrid Julian , Agarwal Prerana , Müller-Peltzer Katharina , Askani Marvin , Benning Leo , Selig Mischa , Diehl Philipp , Kalbhenn Johannes , Trummer Georg , Utzolino Stefan , Wengenmeyer Tobias , Busch Hans-Jörg , Stolz Daiana , Rieg Siegbert , Panning Marcus , Schlett Christopher L. , Bamberg Fabian , Askani Esther 
Published: November 2023

Abstract
Background:
COVID-19 can lead to acute respiratory distress syndrome (ARDS) due to a dysregulated immune response and direct lung damage. Vaccination against COVID-19 bears potential to reduce ARDS prevalence in COVID-19. This study aimed to analyze the effect of COVID-19 vaccination on the occurrence of ARDS in hospitalized COVID-19 patients.
Methods:
The study population of this retrospective, single-center cohort study consisted of hospitalized COVID-19 patients with known vaccination status and chest computed tomography (CT) imaging between July 2021 and February 2022. The onset of ARDS was assessed using the Berlin definition. The impact of vaccination on ARDS in COVID-19 patients was assessed through logistic regression adjusting for demographic differences and confounding factors with statistical differences determined using confidence intervals and effect sizes.
Results:
A total of 167 patients (69% male, average age 58 years, 95% CI [55; 60], 42% fully vaccinated) was included in the data analysis. Vaccinated COVID-19 patients had a reduced relative risk (RR) of developing ARDS (RR: 0.40, 95% CI [0.21; 0.62]). Consequently, non-vaccinated hospitalized patients had a 2.5-fold higher probability of developing ARDS. This risk reduction persisted after adjusting for several confounding variables (RR: 0.64, 95% CI [0.29; 0.94]) in multivariate analysis. The number needed to treat to prevent one ARDS onset in hospitalized COVID-19 patients was three patients. The protective effect of COVID-19 vaccination increased with ARDS severity (RR: 0.61, 95% CI [0.37; 0.92]). Particularly, middle-aged patients (around 50 years old) were at risk for ARDS onset and seemed to benefit from COVID-19 vaccination (RR: 0.51, 95% CI [0.20; 0.90]).
Conclusions:
COVID-19 vaccination showed to reduce the risk of ARDS occurrence in hospitalized COVID-19 patients, with a particularly strong effect in middle-aged patients and those with more severe ARDS.
Future Responses of the Burdur Lake to Climate Change and Uncontrolled Exploitation
Authors: Mert Ahmet , Tavuç İbrahim , Özdemir Serkan , Ulusan Musa Denizhan 
Published: November 2023

Abstract
The changes that have occurred over time in Burdur Lake, which is located in a large area called the lakes region in Turkey, have received extensive attention due to global warming. In this study, we have revealed the changes in the surface area and volume of Burdur Lake by using satellite images. Dams and ponds built on the springs feeding the lake, combined with climate change, have caused dramatic changes in the lake area. Temperature, precipitation, and city (center) population data that can be an indicator of these changes are provided and their relations with the changes in the lake are explained by expressing them over the years. By using the pixel values of the satellite images of the past years, time series analysis was performed for both the surface area and the volume values. The Arima model was used for time series analysis. Results of the time series analysis conducted for the Burdur lake predicted that the lake volume will decrease to 0 in the 2070s. On the other hand, as a result of the time series analysis for the surface area, it was seen that the existing areas decreased dramatically in 2100. It is thought that these decreases in the lake are caused by the unconscious use of water resources feeding the lake for agricultural irrigation and climate change.
Endocannabinoid system genes regulation in the effects evoked by social isolation in rats
Authors: Girella Antonio , Bartolomeo Martina Di , Dainese Enrico , Buzzelli Valeria , Trezza Viviana , D’Addario Claudio 
Published: November 2023

Abstract
Social isolation is a state of lack of social connections, involving the modulation of different molecular signalling cascades and associated with high risk of mental health issues. To investigate if and how gene expression is modulated by social experience at the central level, we analyzed the effects of 5 weeks of social isolation in rats focusing on endocannabinoid system genes transcription in key brain regions involved in emotional control. We observed selective reduction in mRNA levels for fatty acid amide hydrolase (Faah) and cannabinoid receptor type 1 (Cnr1) genes in the amygdala complex and of Cnr1 in the prefrontal cortex of socially isolated rats when compared to controls, and these changes appears to be partially driven by trimethylation of Lysine 27 and acetylation of Lysine 9 at Histone 3. The alterations of Cnr1 transcriptional regulation result also directly correlated with those of oxytocin receptor gene. We here suggest that to counteract the effects of SI, it is of relevance to restore the endocannabinoid system homeostasis via the use of environmental triggers able to revert those epigenetic mechanisms accounting for the alterations observed.
Effect of Curing Light Beam’s Inhomogeneity on the Microhardness of Resin-Based Composite
Authors: Wang Lan , Kim Dohyun , Park Sung-Ho 
Published: November 2023

Abstract

Background
Recent studies have reported the inhomogeneity in the light emitted by dental light-curing units (LCUs). It is essential to understand how this uneven light distribution affects the physical properties of resin-based composites (RBCs) at various points across their surfaces. This study aimed to evaluate the effect of LCU beam’s inhomogeneity on the microhardness of RBCs with different shades and thicknesses.
Methods
Four body (A1B, A2B, A3B, and A4B), one dentin (A3D), and one enamel shade (A3E) of RBC (Filtek Z350 XT) were examined. The specimens were fabricated in four thicknesses (1, 2, 3, and 4 mm) and subjected to a 40-second light-curing. Vickers microhardness testing was performed at the center point, and 3 mm left and right from the center at the bottom surface of each sample. The LCU beam profile was characterized using a beam profiler, while irradiance after specimen passage was measured using a spectrometer. One-way analysis of variance (ANOVA) and Tukey’s posh-hoc tests were used to analyze the effects of shades and thicknesses on irradiance and microhardness, respectively. One-way repeated-measures ANOVA was used to compare the microhardness across different points. Pearson’s correlation analysis examined the relationship between irradiance and microhardness.
Results
The beam profile of LCU revealed inhomogeneous light distribution. Light irradiance was decreased with both the increase in thickness and darker shade of the specimens (p < 0.05). Microhardness was found to decline with an increase in sample thickness (p < 0.05), and was consistently higher at the center point compared to the periphery, particularly in thicker (3 and 4 mm) and darker shades (A3B, A4B, and A3D). A positive correlation was found between the irradiance and microhardness across all evaluated points (p < 0.05).
Conclusions
Inhomogeneous light emission from LCU significantly influences the microhardness of RBC samples, depending on the thicknesses and shades. The findings underline the importance of considering LCU beam inhomogeneity in clinical settings to ensure optimal polymerization of RBC.
Exploring Causal Cytokines and Potential Regulatory Genes in Bronchiectasis: Findings from Mendelian randomization
Authors: Liao Wan-Zhe , Zhou Hao-Bin , Lin Zi-Kai , Zhou Zhi-Yi , Guo Xu-Guang 
Published: November 2023

Abstract
Background
Bronchiectasis is a chronic respiratory disease characterized by irreversible dilation of the bronchi, which leads to impaired mucociliary clearance, recurrent infections, and inflammatory responses. Despite advancements in diagnostic techniques and therapeutic strategies, the underlying etiological factors driving bronchiectasis pathogenesis remain incompletely elucidated.
Methods
Genome-wide data were utilized to conduct two-sample Mendelian randomization focusing on the causality from 41 inflammatory factors on bronchiectasis. Sensitivity tests were carried out to validate the reliability. SMR, coloc, and intermediary Mendelian randomization were utilized to determine latent upstream genes and estimate indirect effects.
Results
Four inflammatory factors’ potential causal effects on bronchiectasis were identified: MMIF (0.85 (0.74, 0.98) 0.029), IL-4 (1.32 (1.09, 1.55) 0.019), IFN-γ (1.28 (1.02, 1.60) 0.032), and FGF-Basic (1.28 (1.03, 1.59) 0.025) (FinnGen R9, IVW, reported as OR (95% CI) P). Sensitivity tests supported the direction consistency of IFN-γ and FGF-Basic’s estimates instead of MMIF and IL-4. RP11-589P10.5 was found to reduce the risk of bronchiectasis, mediated by the IFN-γ concentration (OR = 0.96, proportion = 36.52%).
Conclusions
Our study has identified strong evidence for potential positive causalities from IFN-γ and FGF-Basic. RP11-589P10.5 was found to latently decrease the risk of bronchiectasis, which is mediated by IFN-γ. At the genetic level, we anticipate that the cytokines and the gene can be taken into account in predictive models for bronchiectasis and even as indicators of the severity of the disease, providing new directions for future population research and basic experiments related to bronchiectasis.