bluuebunny/crossref_metadata_2025_split huggingface dataset:
Thyroid gland and heart: a cardiologist’s view on an endocrinological pathology. Review
Authors: Кondratiuk V. E. , Stakhova А. P. 
Published: October 2023

The review of the literature considered the mechanism of action and the role of thyroid hormones (TH) on cardiovascular hemodynamics and, subsequently, on changes in the myocardial structure. A brief description of the genomic and non‑genomic mechanisms of thyroid hormones is provided. The mechanisms of thyroid hormones’ effects on the development of arterial and pulmonary hypertension, atrial fibrillation are highlighted. Attention is focused on the fact that congestive heart failure of the dilatation type develops against the background of hyperthyroidism. A possible connection between thyroid hyperfunction and Takotsubo stress‑induced cardiomyopathy was investigated. The impact of subclinical hyperthyroidism on the development and progression of cardiac pathology is illustrated. The mechanism of influence of hypothyroidism on the parameters of the lipid spectrum, acute phase proteins, insulin sensitivity, but not only the contractile function of the myocardium was considered. Changes in the electrical activity of the heart and its structural and functional changes were determined. Attention is focused on the importance of achieving euthyroidism in both hyperthyroidism and hypothyroidism. Stress‑induced Takotsubo cardiomyopathy is closely related to the hyperthyroid state and is often accompanied by the development of cardiogenic shock. Hyperthyroidism is associated with an increased risk of permanent atrial fibrillation and hypercoagulability. The achievement of euthyroid state can result in the reversal of left ventricular hypertrophy and decrease in the heart chamber dilatation. Even subclinical hyperthyroidism increases the risks of overall mortality and cardiovascular events, especially in the elderly persons. Patients with hypothyroidism are characterized by the development of anemia, dyslipidemia, decreased sensitivity to insulin, which is associated with endothelial dysfunction. In hypothyroidism, in contrast to hyperthyroidism, the risk of atrial fibrillation development is lower due to an increase in the arrhythmogenic threshold, but more typical disorders include sinus bradycardia, atrioventricular blocks of various degrees and prolongation of the QT interval, which are associated with the early development of impaired myocardial relaxation. For patients with thyroid pathology, the achievement of euthyroidism is mandatory to ensure cardio‑ and vasoprotection.
Possibilities of immunocytochemical staining for HBME-1 expression in the «diagnostic search» of differentiated thyroid cancer. Own investigation
Authors: Nechay O. P. , Belemets N. I. , Palamarchuk V. O. , Kvitka D. M. , Kozachuk Y. S. , Tovkai O. A. 
Published: October 2023

Objective — to investigate HBME-1 expression variants on cytological material classified as doubtful (III, IV, V), according to the Bethesda categories, to evaluate the value of the HBME-1 expression test on the corresponding histological material of nodular goiter, follicular tumor with an uncertain potential for malignancy for the differential diagnosis of thyroid carcinoma (ThC).
Materials and methods. The analysis was performed on the data of 14 patients with thyroid nodular lesions and cytological Bethesda categories III, IV, and V (“gray zone“). The HBME-1 expression was determined by the results of immunocytochemical (ICC) and immunohistochemical (IHC) staining with the use of mouse monoclonal antibodies against human HBME-1 (1 : 500; cat № BSB 3459; «Bio SB» «Bioscince for the World» Santa Barbara USA). The HBME-1 expression grade was calculated as the sum of the score for staining intensity and cytoplasmic positive cells square, present in the IHC sample. HBME-1 positive result was considered with an IHC score >6 point.
Results. From 14 investigated patients, five were defined as HBME-1 positive. According to the postoperative histological conclusion for the group of HBME-1 positive patients, thyroid carcinoma was diagnosed in four subjects, including three cases of papillary ThC and one follicular ThC; in one patient follicular tumor of uncertain malignant potential (FT-UMP) was reported. Importantly, immunocytochemical and immunohistochemical HBME-1 reactions in the specimens of these patients were of the same intensity. Among 9 HBME-1 preoperative negative patients, none had malignancy according to the final histological study. Nodular goiter was diagnosed in six patients, and tumor of uncertain malignant potential (FT-UMP) was reported for three subjects. Histological specimens of all 9 patients were HBME-1 negative as well. The obtained results demonstrated an increase in cancer detection rates with increasing Bethesda category. Application of statistical software for biomedical research МedCalc revealed that positive predictive value (PPV) of the HBME-1 expression test was 80% (95% confidence interval CI 38.4—96.3%), and diagnostic efficiency was 92.9% (CI 66.1—99.8%). These results suggest the great potential of the test, however, due to the limited observations, the confidence intervals are too wide.
Conclusions. HBME-1 can be used as an immuno­cytochemical marker for the differentiation of benign and malignant thyroid nodules, its use will help to reduce the number of unnecessary surgical removals of benign tumors, which will improve the quality of life of patients and reduce the burden on medical services.
Diagnosis and treatment of metabolic-associated fatty liver disease in patients with type 2 diabetes mellitus. Review
Authors: Tkach S. M. 
Published: October 2023

Metabolic‑associated fatty liver disease (MAFLD) is a new clinical definition of fatty liver disease that changes the definition of non‑alcoholic fatty liver disease (NAFLD) from a disease of exclusion to a disease of inclusion, in which the main pathogenic processes originate from metabolic dysfunction, primarily in type 2 diabetes mellitus (T2DM) and obesity. In recent years, MAFLD has become an epidemic and is closely associated with T2DM and a significant synergistic increase in the risk of cardiovascular disease. The presence of MAFLD significantly increases the risk of T2DM development, and the risk of new onset of T2DM in patients with MAFLD doubles. When managing patients with MAFLD and T2DM, the presence of fibrous nonalcoholic steatohepatitis (NASH) should be actively detected, for which non‑invasive indicators should first be used, such as FIB‑4 and FNI, which are available at the level of primary care. Despite evidence of utility in improving diagnosis, the effectiveness of many of the above non‑invasive tests for detecting fibrosis, particularly in unselected populations with advanced fibrosis, is low and generally remains uncertain at the primary care level. Modifications of lifestyle and diet have traditionally been considered the best therapeutic option for MAFLD in T2DM, with weight loss of ≥7% significantly improving steatosis, leading to reductions in NASH activity and glycemia. At the same time, only 40% of patients achieve this goal and reduce the activity of steatohepatitis, emphasizing the difficulty in treating MAFLD only by lifestyle changes. Nevertheless, mandatory dietary and lifestyle modification should still be recommended for patients with MAFLD, along with antidiabetic drugs that can reduce liver enzyme activity, inflammation, and fibrosis, such as PPARγ inhibitors, SGLT‑2i, GLP‑1 RA, as well as dual GIP and GLP‑1 RA agonists.
Assessment of the efficacy of the combination of α-lipoic acid preparation and synbiotics in the protocol therapy of hypothyroidism combined with chronic pancreatitis
Authors: Salamadze O. О. , Babinets L. S. 
Published: October 2023

Hypothyroidism (Ht) is a common clinical condition with variable prevalence. This disease is often associated with chronic pancreatitis (CP). Consensus exists regarding the necessity to treat patients with Ht in comorbidity with CP to reduce the risk of complications and the frequency of exacerbations, to reduce the activity of the progression of the pathological process, and to improve the quality of life.
Objective — to evaluate the effects of additional use of thioctic acid and synbiotics combination in the conventional treatment on the indicators of the functional state of thyroid gland (THG) and pancreas in patients with Ht in comorbidity with CP.
Materials and methods. Investigation involved 107 patients with a comorbid course of Ht and CP, who were divided into 3 groups according to the complex treatment programs: the first group consisted of 32 subjects, who received protocol treatment (PT) of Ht and CP, the second included 36 patients (PT + α‑lipoic acid preparation (Dialipon Turbo), the third — 39 patients (PT + α‑lipoic acid preparation + synbiotic (Lactimak Forte). The groups were comparable by age and gender. The functional state of the pancreas was assessed using the level of fecal α‑elastase (enzyme immunoassay), pancreatic α‑amylase (immunochemical method), and the coprogram index in points. Thyroid function was assessed by the levels of thyrotropic hormone TSH, free triiodothyronine T3 and free thyroxine T4 (chemiluminescent immunoassay). The obtained data were processed with statistical methods.
Results. The positive dynamics was established in all groups, but the degree of its expression differed. Thus, the level of fecal α‑elastase increased by 57.54% — in the 1st group, by 78.27% — in the 2nd group, by 89.94% — in the 3rd group; pancreatic α‑amylase decreased by 29.68% — in the 1st group, by 39.19% — in the 2nd group, by 42.44% — in the 3rd group; the total coprogram index decreased by 25.11% — in the 1st group, by 47.57% — in the 2nd group, by 84.91% — in the 3rd group. T3 dynamics was 13.9% in the 1st group, 48.69% in the 2nd group, 78.17% in the 3rd group. Dynamics of T4 — 11.3% in the 1st group, 29.98% — in the 2nd group, 35.37% — in the 3rd group. The dynamics of TSH was 19.66%, 31.81%, 69.41%, respectively.
Conclusions. It has been proven that the use of the proposed treatment regimen including the combination of the drug α‑lipoic acid and the synbiotic Laktimak Forte promoted the improvement of pancreas functions and levels of thyroid hormones compared to those in the group of protocol treatment: the level of fecal α‑elastase increased by 89.94%; pancreatic α‑amylase — by 42.44%; coprogram index — by 84.91%; T3 — by 78.17%; T4 — by 35.37%; TSH — by 69.41% (p <0.01).
Impact of wartime stress factors on the metabolic status of the civilian population
Authors: Kolesnikova O. V. , Zaprovalna O. Y. , Yemelianova N. Y. , Radchenko A. O. , Galchinska V. Y. 
Published: October 2023

Materials and methods. As part of the longitudinal study, 29 civilians were examined; all of them remained in their place of residence during the war, were not directly in the combat areas and did not receive physical damage. Body composition was determined by the method of bioelectrical impedance using Composition Monitor BF511, Omron, including body fat percentage (FAT, %), skeletal muscle percentage (MUS, %), visceral fat level (VIS, %). Hematological and biochemical investigations were conducted according to the standard methods. The enzyme immunoassay with appropriate sets of reagents was used to determine serum levels of insulin, C­reactive protein, sirtuin­1 (SIRT1), tumor necrosis factor α (TNF­α), and dehydroepiandrosterone (DHEA). The saliva cortisol levels were measured by enzyme immunoassay as well. Molecular genetic studies included determination of the relative length of telomeres of blood leukocytes.
Results. The mean age of the examined subjects was 53.05 ± 12.06 years, women made up 55.2 % (n = 16). The average time between the prewar visit and the wartime visit was 12.1 ± 2.4 months. When assessing the anthropometric status of the increase in the body mass index, waist circumference and hips: (26.82 ± 3.58 vs 29.67 ± 3.92 kg/m2, p = 0.0184; 84.93 ± 15.58 vs 100.03 ± 12.57 cm, p = 0.0021; 98.57 ± 6.69 vs 106.75 ± 6.73 cm, p = 0.0004), respectively. The most significant changes occurred in the VIS indicator (8.77 ± 3.44 vs 12.88 ± 4.57, p = 0.0003). The significant changes of other parameters were not observed during the study. Correlation analysis of stress indicators (cortisol, DHEA and their ratio) with clinical anthropometric and metabolic indicators, demonstrated their probable association with body composition (cortisol/DHEA & MUS, cortisol/DHEA & FAT), lipid metabolism disorder (cortisol/DHEA & total cholesterol, cortisol/DHEA & low­density lipoprotein cholesterol) and the number of leukocytes (p < 0.05).
Conclusions. Among the civilian population, persons who remained in their place of residence during the war showed negative changes in anthropometric status compared to the pre­war period. The impact of a psychotraumatic factor on the anthropometric status, body composition and lipid metabolism in persons who did not change their place of residence during the war is confirmed by the highly probable relationship of the stress indicator (cortisol/DHEA ratio) with the corresponding indicators. Among the civilian population, in persons who did not change their place of residence during the war, no reliable changes in the parameters related to aging (telomeres, SIRT1) compared to the pre­war period were demonstrated.
Evaluating Distributive Fairness of Remuneration System: The Role of Equity Sensitivity in Explaining Employee Well-being and Organizational Citizenship Behaviour
Authors: Yuliana Elsa Sari , Zawitri Sari , PS Widodo , Kartikawati Theresia Siwi 
Published: October 2023

This study aims to test the effect of remuneration system fairness on subjective well-being and OCB. This research also aims to test the moderating role of equity sensitivity in the effect of remuneration system fairness on subjective well-being. The technique of sample collection employed purposive sampling technique. The hypothesis testing employed path coefficient value and t-test using SmartPLS 3.0. In accordance with the test results show that in the context of public universities in Indonesia, namely PU, employee OCB is influenced by the remuneration system variable and subjective welfare variable. This study also concludes that subjective well-being is a mediator between the two. On the other hand, the moderating role of equity sensitivity in the effect of fairness remuneration on subjective well-being is not well-proven. Theoretically, this research provides generalization to the previous studies, as well as complementing the need for balancing mediator and moderator variables in the correlation between remuneration system fairness and OCB. Practically, this study denotes that organizations need to take concern about fairness in the regulations of remuneration system.
Mencahayai the dark night of the soul dan signifikansi teologi estetika dalam ziarah pemulihan trauma
Authors: Harefa Oinike Natalia 
Published: October 2023

Traumatic experiences, either experienced personally or communally due to unforeseeable events, can lead to prolonged suffering. Therefore, resources for trauma healing are essential. Trauma healing may undergo a process called the dark night of the soul, a historical event with potentially painful and destructive processes, yet leading to liberation from the trauma's grip. This paper aims to elaborate on the dark night of the soul based on the experiences of Teresa of Avila using an Aesthetic Theology perspective. I employ a qualitative research method utilizing literature reviews and interviews. The beginning of this article emphasizes trauma as a theological issue, indicating a need to provide answers that lead to hope. I also interpret trauma as a condition closely related to the concept of the dark night of the soul. The experiences of Teresa of Avila are discussed in detail. My findings are that the idea of the dark night of the soul, from an Aesthetic Theology perspective, can serve as a theological resource for the pilgrimage of trauma recovery. AbstrakPengalaman traumatik yang dialami secara personal maupun komunal oleh karena peristiwa yang tak tertanggungkan dapat membawa pada penderitaan yang berkepanjangan. Oleh karena itu, sumber-sumber pemulihan trauma dibutuhkan. Pemulihan trauma dapat melewati proses yang disebut dengan the dark night of the soul, yakni peristiwa historis dengan proses yang dapat saja menyakitkan dan menghancurkan namun membawa pada pembebasan dari keterikatan pada trauma tersebut. Tulisan ini bertujuan untuk mengelaborasi the dark night of the soul berdasarkan pengalaman Teresa dari Avila dengan menggunakan perspektif Teologi Estetika. Saya menggunakan metode penelitian kualitatif dengan studi kepustakaan dan wawancara. Bagian awal artikel ini menekankan trauma sebagai persoalan teologis sehingga ada kebutuhan untuk memberi jawaban yang menuntun pada pengharapan. Saya juga memaknai trauma sebagai kondisi yang dekat dengan konsep the dark night of the soul. Pengalaman Teresa dari Avila dibahas secara khusus. Temuan saya adalah konsep the dark night of the soul berdasarkan perspektif Teologi Estetika dapat menjadi sumber teologi bagi ziarah pemulihan trauma.
Pembelajaran berbasis semiotika bagi kecerdasan spiritual anak dalam konteks keluarga Kristen Toraja
Authors: Rantesalu Syani Bombongan , Herman Joffri 
Published: October 2023

The struggle to educate children spiritually cannot be separated from the question, is learning carried out effectively in various ways, or is it burdensome? There are many ways to achieve educational goals, from changing the curriculum. However, something that is sometimes forgotten is the study of semiotics, which is related to signs, where these signs have meaning and can be understood. In the Toraja context, many signs are generally understood, whether in symbols or poetry, which are generally understood in terms of their meaning and purpose. If it is related to spirituality, then this sign, which is generally understood, is related to beliefs in life, values, and rules adhered to by the Torajan people. This research aims to develop children's spirituality by analyzing the symbols in Tana Toraja based on learning Deuteronomy 6:4-9. Semiotics-based learning is very effective and interesting because it does not require children to memorize or force them to understand learning with new concepts but with symbols that are ingrained, both verbal and non-verbal. The results of this research can also be a reference for learning in developing spiritual intelligence globally because symbols are so close to everyone in various regions and countries. AbstrakPergumulan dalam mencerdaskan anak secara spiritual tidak terlepas dari pertanyaan, apakah pembelajaran itu terlaksanakan secara efektif dengan berbagai cara, ataukah justru membebani? Banyak cara yang ditempuh untuk sampain pada tujuan pendidikan yang dimulai dari perubahan kurikulum. Namun, hal yang terkadang dilupakan adalah pembelajaran semiotika, yang berkaitan dengan tanda, di mana tanda tersebut memiliki makna dan dapat dimengerti. Dalam konteks Toraja, banyak tanda yang dipahami secara umum baik itu berupa simbol, mau-pun syair, yang kemudian dipahami secara umum baik makna maupun tujuannya. Jika dikaitkan dengan spiritualitas, maka tanda yang secara umum dipahami ini berkaitan dengan kepercayaan atas nilai-nilai kehidu-pan maupun aturan yang dianut oleh orang Toraja. Penelitian ini bertu-juan untuk mengembangkan spiritualitas anak dengan menganalisis sim-bol-simbol yang ada di Tana Toraja berdasar pada pembelajaran Ulangan 6:4-9. Pembelajaran berbasis semiotika sangatlah efektif dan menarik karena tidak menuntut anak untuk menghafal ataupun memaksa mema-hami pembelajaran dengan konsep yang baru, melainkan dengan simbol-simbol yang telah mendarah daging, baik secara verbal maupun non-verbal. Hasil penelitian ini juga dapat menjadi acuan pembelajaran dalam mencerdaskan spiritual secara global oleh karena simbol begitu dekat dengan setiap orang di berbagai daerah maupun negara.
Gereja sebagai administrator misi keadilan sosial: Sebuah panggilan misional holistik Pentakostal
Authors: Gultom Junifrius 
Published: October 2023

This research aims to show the holistic mission of the Pentecostal perspective, which departs from the Christian concept of holistic mission, namely Missio Dei, where God initiates the mission. The trinitarian framework of sending becomes a biblical philosophical foundation for understanding the Christian mission centered on God rather than the church, a shift from an ecclesiocentric mission to a theocentric mission. The church's place is important as the administrator of God's work in the world. The method used is descriptive qualitative with a library research approach, which brings the concept of holistic Christian mission, in general, closer to the potential of Pentecostal pneumatic spirituality. Suppose the Pentecostal movement can continue to realize the potential of a friendly pneumatic spirituality (hospitality) and embrace all of creation. In that case, that solid mission drive will enable Pentecostals to present the church as an administrator of social justice. AbstrakTujuan dari penelitian ini untuk menunjukkan misi holistik perspektif Pentakostal yang bertolak dari konsep misi holistik Kristen, yakni Missio Dei, di mana Allah sebagai inisiator misi. Kerangka pengutusan trinitarian menjadi fondasi filosofis alkitabiah untuk memahami misi Kristen yang berpusat pada Allah ketimbang gereja, sebuah pergeseran dari ecclesiocentric mission ke theocentric mission. Tempat gereja menjadi penting sebagai administrator dari pekerjaan Allah di dunia. Metode yang dipergunakan adalah kualitif deskriptif dengan pendekatan library research yang mendekatkan konsep misi holistik Kristen pada umumnya dengan pontensi spritualitas pneumatik Pentakostal. Jika gerakan Pentakostal dapat terus menyadari akan potensi spiritualitas pneumatik yang ramah (hospitalitas) dan merangkul semua ciptaan, maka dorongan misi yang kuat itu memungkinkan orang-orang Pentakostal mampu menghadirkan gereja sebagai administrator keadilan sosial.