bluuebunny/crossref_metadata_2025_split huggingface dataset:
Photoelectrocatalysis and nanohybrids in wastewater treatment
Authors: Sharma Sweta , Devi Pooja 
Published: January 2024

Abstract
The rise in global industrialization, urbanization, and population growth has contributed to a significant increase in the production of large volumes of wastewater. The inadequate management of this valuable resource, rich in energy and minerals, has emerged as a worldwide concern. While conventional methods for treating wastewater are somewhat effective, they struggle to address persistent pollutants such as pesticides, textile dyes, pharmaceuticals, and personal care products. To tackle these challenges, there is a need for innovative solutions. Advanced oxidation processes (AOPs) present a promising alternative for breaking down these complex organic pollutants that are resistant to traditional chemical oxidants. Among these AOPs, photoelectrocatalysis (PEC) stands out because it not only effectively degrades pollutants, but it also offers the potential to harness energy from wastewater. This chapter discusses PEC, exploring its recent advancements, particularly focusing on the application of nanohybrids as photoelectrodes for enhancing wastewater treatment efficiency.
In-silico Binding, Stability, Pharmacokinetics, and Toxicity Studies on
Natural (-)-ambrox Metabolites as Binding Ligands to Luminal B and
Triple-negative/basal-like Proteins for Breast Cancer Therapy
Authors: Haikal Abdullah , Thangavel Neelaveni , Albratty Mohammed , Najmi Asim , Al Hazmi Hassan Ahmed , Sivadasan Durgaramani , Khuwaja Gulrana , Shamkh Israa M. 
Published: January 2024

Background:
Breast cancer is the most prevalent malignant tumour in women of all races
and is the second largest cause of cancer-related death in the majority of races. Based on the pattern
of gene expression, five intrinsic or molecular classifications for breast tumours are frequently used.
Our research, which is presently being utilized to treat breast cancer and has the potential to significantly
change the course of the illness, is focused on two of them: luminal B breast cancer and triplenegative/
basal-like breast cancer.

Methods:
Screening a database containing millions of drug molecules or phytochemicals has become
rapid and simple due to computer-aided drug design (CADD) techniques. In the current work, nine
natural compounds were screened for ambrox from a sperm whale using docking research.

Results:
Following docking studies, nine substances were discovered to interact with basal-like and
luminal B breast cancer proteins. All nine metabolites, however, adhered to Lipinski's rule of five
and had sufficient oral bioavailability. The greatest binding affinities were demonstrated by
13,14,15,16-tetranorlabdane-3-oxo-8,12-diol, 6-β-hydroxy ambrox, 1-α-hydroxy-3-oxoambrox, and
2-α-3-β-dihydroxy ambrox.

Conclusion:
Therefore, it can be concluded that research on molecular docking and pharmacological
mimics may hasten the discovery of new medications. The use of ambrox metabolites in the treatment
of breast cancer also requires future perspectives on their therapeutic use.
Exploring the Molecular Mechanisms of Astragalus membranaceus in
Treating Pre-eclampsia using Network Pharmacology and Molecular
Docking
Authors: Zhong Jing , Lan Liubing 
Published: January 2024

Background:
Pre-eclampsia (PE) is a pregnancy-related complication that has a global
prevalence of 3-5% among pregnant women.

Objective:
The objective of this study is to examine the molecular mechanism underlying the therapeutic
effects of Astragalus membranaceus (AE) in the treatment of PE through the application of
network pharmacology and molecular docking.

Methods:
The databases, including TCMSP, Uniprot, Genecards, STRING, and DAVID, and software,
including jvenn, Cytoscape, and AutoDock Vina, were used to do the analysis.

Results:
Sixteen AE-related active ingredients were screened, involving 127 targets, among which
the main active ingredients included kaempferol, quercetin, and jaranol, etc. The primary targets of
AE for the management of PE encompassed AKT1, CASP3, EGFR, IL1B, IL6, MMP9, PTGS2,
TNF, TP53, and VEGFA. The outcomes of the enrichment analysis revealed that AE was predominantly
implicated in pathways such as the IL-17 signaling pathway and PI3K-Akt signaling pathway,
among others. The molecular docking findings confirmed that the principal active constituents exhibit
favorable binding to their central targets. Specifically, the molecular docking results evinced that
the primary active ingredients evince robust binding activity towards the core targets.

Conclusion:
AE has the potential to act synergistically in the management of PE by engaging multiple
components, targets, and pathways, thereby establishing a basis for further exploration of its material
basis and mechanism of action.
In silico Investigation of the Pro-apoptotic Potential of Syringic Acid Analog
Authors: Hosseini Hossein , Khorasani Reza Rajaie , Ketabi Sepideh , Nikmaram Farrokh Roya 
Published: January 2024

Background:
Conformational changes in BAX are associated with the activation of its
pro-apoptotic potential. Previously, small molecule BAX antagonists have been shown to bring about
apoptosis by inducing conformational changes in BAX by direct binding to the serine 184 site of
BAX.

Methods:
In this article, we have proposed that syringic acid analog SA14 can incur apoptosis by
directly binding to and inducing conformational changes in BAX. The pro-apoptotic potential of
SA14 has been investigated using an in silico structure-based approach, i.e., docking and molecular
dynamics computations are employed to study the binding of SA14 to the residues of the active site
of BAX.

Results:
Based on docking results, four BAX-SA14 complexes, each representative of a cluster of
conformations, have been selected for molecular dynamics simulations. The root mean square deviation has indicated the formation of stable conformations for two of the complexes. Other parameters,
such as root mean square fluctuation, radius of gyration, and solvent accessible surface area, have
been used to confirm the results, which have indicated favorable binding between BAX and SA14.

Conclusion:
Overall, the results have indicated that SA14 can bring about stable conformational
changes in BAX and shows merit as a potential BAX-activating pro-apoptotic agent worthy of further experimental studies.
Discovery of Novel Pyrimidine Based Small Molecule Inhibitors as VEGFR-2 Inhibitors: Design, Synthesis, and Anti-cancer Studies
Authors: Dhawale Sachin A. , Mokale Santosh N. , Dabhade Pratap S. 
Published: January 2024

Background:
Receptor tyrosine kinases (RTKs) are potent oncoproteins in cancer
that, when mutated or overexpressed, can cause uncontrolled growth of cells, angiogenesis, and
metastasis, making them significant targets for cancer treatment. Vascular endothelial growth
factor receptor 2 (VEGFR2), is a tyrosine kinase receptor that is produced in endothelial cells
and is the most crucial regulator of angiogenic factors involved in tumor angiogenesis. So, a
series of new substituted N-(4-((2-aminopyrimidin-5-yl)oxy)phenyl)-N-phenyl cyclopropane-
1,1-dicarboxamide derivatives as VEGFR-2 inhibitors have been designed and synthesized.

Background:
Receptor tyrosine kinases (RTKs) are potent oncoproteins in cancer
that, when mutated or overexpressed, can cause uncontrolled growth of cells, angiogenesis, and
metastasis, making them significant targets for cancer treatment. Vascular endothelial growth
factor receptor 2 (VEGFR2), is a tyrosine kinase receptor that is produced in endothelial cells
and is the most crucial regulator of angiogenic factors involved in tumor angiogenesis. So, a
series of new substituted N-(4-((2-aminopyrimidin-5-yl)oxy)phenyl)-N-phenyl cyclopropane1,1-dicarboxamide derivatives as VEGFR-2 inhibitors have been designed and synthesized.

Methods:
Utilizing H-NMR, C13-NMR, and mass spectroscopy, the proposed derivatives were
produced and assessed. HT-29 and COLO-205 cell lines were used for the cytotoxicity tests.
The effective compound was investigated further for the Vegfr-2 kinase inhibition assay, cell
cycle arrest, and apoptosis. A molecular docking examination was also carried out with the
Maestro-12.5v of Schrodinger.

Results:
In comparison to the reference drug Cabozantinib (IC50 = 9.10 and 10.66 μM), compound
SP2 revealed promising cytotoxic activity (IC50 = 4.07 and 4.98 μM) against HT-29 and
COLO-205, respectively. The synthesized compound SP2 showed VEGFR-2 kinase inhibition
activity with (IC50 = 6.82 μM) against the reference drug, Cabozantinib (IC50 = 0.045 μM).
Moreover, compound SP2 strongly induced apoptosis by arresting the cell cycle in the G1
phase. The new compounds' potent VEGFR-2 inhibitory effect was noted with key amino acids
Asp1044, and Glu883, and the hydrophobic interaction was also observed in the pocket of the
VEGFR-2 active site by using a docking study.

Conclusion:
The results demonstrate that at the cellular and enzyme levels, the synthetic compounds
SP2 are similarly effective as cabozantinib. The cell cycle and apoptosis data demonstrate
the effectiveness of the suggested compounds. Based on the findings of docking studies,
cytotoxic effects, in vitro VEGFR-2 inhibition, apoptosis, and cell cycle arrest, this research has
given us identical or more effective VEGFR-2 inhibitors.
Multiple Myeloma Patient with Secondary Liver and Tongue Involvement, Complicated by COVID-19-Induced ARDS: An Autopsy Case Report and Literature Review
Authors: Matskevych Viktoriya , Ilnytska Khrystyna , Lenchuk Tetiana , Mytsyk Yulian , Kindrativ Elvira , Hlushko Nataliia 
Published: January 2024

Background. Liver involvement secondary to multiple myeloma is a rare and uncommon radiologic finding. Such extraosseous secondary lesions as well as tongue involvement require pathohistological confirmation to prevent misdiagnosis. Clinical and laboratory diagnostics are challenging in patients with COVID-19 and underlying multiple myeloma and its secondary lesions, leading to difficulties in treatment and outcomes.
Case Report. A 64-year-old male patient, not vaccinated against COVID-19, with a history of multiple myeloma presented with symptoms of headache, fatigue, dyspnea, cough, and fever. The patient’s medical history was intricate, involving cholecystectomy and a diagnosis of multiple myeloma, which was subsequently treated with chemotherapy and radiation therapy. Additionally, uncommon liver and tongue involvement secondary to multiple myeloma was found. Upon admission, the patient’s peripheral oxygen saturation was 90%, accompanied by increasing shortness of breath and a respiratory rate of 26 breaths per minute. A positive COVID-19 test was recorded. A lung computed tomography revealed bilateral multifocal areas of ground-glass opacity and consolidation, encompassing the entire pulmonary regions, corresponding to CO-RADS 6. The patient was admitted to the intensive care unit. Despite initiating oxygen support and symptomatic therapy, the patient’s death occurred. Autopsy confirmed the development of severe acute respiratory distress syndrome and bilateral hemorrhagic pneumonia, with multiple myeloma as a contributing factor.
Conclusions. This case report highlighted the rare occurrence of secondary liver involvement in multiple myeloma, characterized by nodules with distinct imaging features. It underscored the importance of identifying coexisting lesions, such as tongue involvement, and the diagnostic challenges they pose. Additionally, the case emphasized the need for comprehensive clinical assessment in patients with concurrent COVID-19 and underlying multiple myeloma, as it may lead to the development of acute respiratory distress syndrome.
Pemberdayaan Masyarakat Berbasis Potensi Lokal di Wisata Lembah Desa Pulutan
Authors: Safri Anggara David , Rezki Muhammad 
Published: January 2024

Abstrak
Dahulu desa selalu menjadi kawasan yang selalu diidentikkan dengan kemiskinan dan keterbelakangan. Namun, pada beberapa tahun terakhir desa menjadi sorotan dari berbagai pihak. Pasalnya, pemerintah memberikan otonomi khusus untuk desa agar bisa membangun wilayahnya sesuai dengan potensi lokal yang dimiliki melalui UU Desa. Salah satu desa yang berhasil mengimplementasikan amanat ini adalah Desa Pulutan melalui wisata lembah desa. Artikel ini bertujuan untuk mengkaji lebih mendalam terkait konsep pemberdayaan yang dilakukan di wisata lembah desa. Peneliti menggunakan metode kualitatif deskriptif dengan pendekatan tahapan pemberdayaan antara lain; penyadaran, pengkapasitasan dan pemberdayaan. Hasil dari penelitian ini menunjukkan bahwa wisata yang dikelola BUMDes ini dilakukan dengan memanfaatkan potensi lembah desa dan mengajak masyarakat untuk bermitra dengan pihak pengelola dengan cara menjajakan kuliner tradisional. Selain itu, fasilitas dari lembah desa menarik karena menyuguhkan sistem pertanian modern yakni mina padi.
Kata kunci: Pemberdayaan, Masyarakat, Wisata Lembah Pulutan
Abstract
In the past, villages were always identified with poverty and underdevelopment. However, recently villages have been in the spotlight from various parties. This is because the government has given special autonomy to villages so that they can develop their territory according to their local potential through the UU Desa. Village that has successfully implemented this mandate is Pulutan Village through Wisata Lembah Desa. This article aims to examine more deeply the concept of empowerment carried out in valley village tourism. The researcher uses descriptive qualitative method with empowerment stage approach including; awareness, capacity building and empowerment. The results indicate that tourism managed by BUMDes is carried out by utilizing the potential of the village valley and inviting the community to partner with the manager by selling traditional culinary delights. In addition, the facilities from the village valley are interesting because they present a modern agricultural system, namely mina padi.
Key words: Empowerment, Community, Pulutan Valley Tourism
The Association of Intra-Abdominal Adhesions with Peritoneal Dialysis Catheter-Related Complications
Authors: Qureshi Mohammad Azfar , Maierean Serban , Crabtree John H. , Clarke Alix , Armstrong Sean , Fissell Rachel , Jain Arsh K. , Jassal Sarbjit V. , Hu Susie L. , Kennealey Peter , Liebman Scott , McCormick Brendan , Momciu Bogdan , Pauly Robert P. , Pellegrino Beth , Perl Jeffrey , Pirkle James L. , Plumb Troy J. , Seshasai Rebecca , Shah Ankur , Shah Nikhil , Shen Jenny , Singh Gurmukteshwar , Tennankore Karthik , Uribarri Jaime , Vasilevsky Murray , Yang Robert , Quinn Robert R. , Nadler Ashlie , Oliver Matthew J. ,   on behalf of the North American Peritoneal Dialysis Registry
Published: January 2024

Background
This study investigated the association of intra-abdominal adhesions with the risk of peritoneal dialysis (PD) catheter complications.

Methods
Individuals undergoing laparoscopic PD catheter insertion were prospectively enrolled from eight centers in Canada and the United States. Patients were grouped based on the presence of adhesions observed during catheter insertion. The primary outcome was the composite of PD never starting, termination of PD, or the need for an invasive procedure caused by flow restriction or abdominal pain.

Results
Seven hundred and fifty-eight individuals were enrolled, of whom 201 (27%) had adhesions during laparoscopic PD catheter insertion. The risk of the primary outcome occurred in 35 (17%) in the adhesion group compared with 58 (10%) in the no adhesion group (adjusted HR, 1.64; 95% confidence interval [CI], 1.05 to 2.55) within 6 months of insertion. Lower abdominal or pelvic adhesions had an adjusted HR of 1.80 (95% CI, 1.09 to 2.98) compared with the no adhesion group. Invasive procedures were required in 26 (13%) and 47 (8%) of the adhesion and no adhesion groups, respectively (unadjusted HR, 1.60: 95% CI, 1.04 to 2.47) within 6 months of insertion. The adjusted odds ratio for adhesions for women was 1.65 (95% CI, 1.12 to 2.41), for body mass index per 5 kg/m2 was 1.16 (95% CI, 1.003 to 1.34), and for prior abdominal surgery was 8.34 (95% CI, 5.5 to 12.34). Common abnormalities found during invasive procedures included PD catheter tip migration, occlusion of the lumen with fibrin, omental wrapping, adherence to the bowel, and the development of new adhesions.

Conclusions
People with intra-abdominal adhesions undergoing PD catheter insertion were at higher risk for abdominal pain or flow restriction preventing PD from starting, PD termination, or requiring an invasive procedure. However, most patients, with or without adhesions, did not experience complications, and most complications did not lead to the termination of PD therapy.

Podcast
This article contains a podcast at https://www.asn-online.org/media/podcast/CJASN/2024_11_15_CJASN2024Trainee2nd.mp3
Cross-Border Regulatory Cooperation and Corporate Social Responsibility Reporting
Authors: Chen Xiaomeng Charlene , Luo Le , Tsang Albert 
Published: January 2024

ABSTRACT
This study investigates the impact of the SEC’s regulatory cooperation and enforcement on the corporate social responsibility (CSR) reporting practices of U.S.-listed foreign firms using a country’s Multilateral Memorandum of Understanding (MMoU) signing as a catalyst. The MMoU, a cooperative agreement among global securities regulators, enhances the SEC’s ability to engage in cross-border enforcement actions in collaboration with foreign counterparts. Our findings reveal a significant enhancement in both the quantity and quality of CSR reporting among U.S.-listed foreign firms after their home country signs the MMoU. This improvement sets them apart from their non-U.S.-listed counterparts in the same foreign location. Notably, this positive change is more pronounced among foreign firms from signatory countries with weak country-level institutions. This study contributes to the understanding of how regulatory changes, specifically MMoU adoption, influence CSR reporting, emphasizing the strategic role it plays for firms in the face of heightened regulatory cooperation and enforcement.
Data Availability: Data subject to third-party restrictions.
JEL Classifications: M41; G18; P48; G32.
Private Loan Issuance and Risk Factor Disclosure
Authors: Dai Lili , Landsman Wayne R. , Peng Zihang 
Published: January 2024

ABSTRACT
This study provides evidence that private loan issuance offers opportunities for borrowers to learn new information about their own risks and subsequently disclose such information in their risk factor disclosures (RFDs) to satisfy lenders’ demand for transparency about borrowers’ risks. This loan issuance effect on risk disclosures is more pronounced when greater learning opportunities are present and when lenders have a stronger demand for borrowers’ risk information transparency. Further analyses suggest that the enhanced risk disclosures following loan issuance not only benefit lenders by reducing the costs of accessing the secondary credit markets, but also create spillover benefits for equity investors by increasing risk information about the borrower and reducing uncertainty about the borrower’s risk. Taken together, these findings suggest that borrowers’ private interactions with lenders provide new opportunities for managers to generate and reflect fresh information in corporate risk disclosures, ultimately benefiting a wide range of capital market participants.
Data Availability: Data are available from the sources identified in the paper.
JEL Classifications: G21; G32; M41.
High concordance of blood glucose measurement in cats between a beta prototype glucometer device and a reference laboratory standard in a clinical setting
Authors: Walker Alex , Stewart Samuel D. 
Published: January 2024

Abstract

OBJECTIVE
The objective of this study was to evaluate the accuracy of a beta prototype version of a new portable blood glucose meter in feline patients.

ANIMALS
60 client-owned cats.

METHODS
In this prospective study, 3-mL blood samples were collected from each cat and analyzed in triplicate using a beta prototype device (AlphaTRAK 3 [AT3]) and by a reference lab standard immediately after collection. Accuracy of the AT3 device was determined in accordance with the International Organization of Standardization (ISO) 15197:2013 criteria, including Bland-Altman plotting and consensus error grid analysis. A Passing-Bablok regression analysis was also performed.

RESULTS
96% of feline measurements fell within the ISO accuracy threshold, and 100% of measurements fell within zones A and B of the consensus error grid, meeting the ISO accuracy requirements. There was no significant bias in the data according to the Bland-Altman analysis. Within the full range of glucose concentrations (20 to 750 mg/dL) the correlation coefficient between the AT3 and the reference lab standard was 0.99. There was no significant constant or proportional bias present in the data.

CLINICAL RELEVANCE
The AT3 device met the ISO requirements and is accurate for measurement of blood glucose concentrations in cats.
Fatigue Behaviour of Medium Carbon Steel Assessed by the Barkhausen Noise Method
Authors: Makowska Katarzyna , Szymczak Tadeusz , Kowalewski Zbigniew L. 
Published: January 2024

Abstract
In this paper, an attempt to estimate the stage of the fatigue process using the Barkhausen noise method is studied. First, microstructural and static tensile tests were carried out and, subsequently, fatigue tests up to failure were conducted. After determination of the material behaviour in the assumed static and dynamic conditions, the interrupted fatigue tests were performed. Each specimen was stressed up to a different number of cycles corresponding to 10%, 30%, 50%, 70% and 90% of fatigue lifetime for the loading conditions considered. In the next step of the experimental programme, the specimens were subjected to the Barkhausen magnetic noise measurements. Various magnetic parameters coming from the rms Barkhausen noise envelopes were determined. The linear relationship betweenthe full-width at half-maximum (FWHM) of the Barkhausen noise envelope and the number of loading cycles to fracture was found. Specimens loaded up to a certain number of cycles were also subjected to a tensile test to assess an influence of fatigue on the fracture features.
Reporting Offences and Protection of the Public Interest in Moravian Provincial Law in the 16th Century
Authors: Janišová Jana 
Published: January 2024

Abstract
The legal institute of whistleblowing as a tool for detecting wrong-doing, especially in large corporations, and at the same time as an institute of whistleblower protection is a matter of modern law and its wider use has been registered only in recent decades. However, some aspects of whistleblowing, in particular the protection of the public interest and the possibility for weaker parties to report offences to an official, can already be found in older law in many different countries. Moravian provincial law was the main law on the territory of the Margraviate of Moravia, although there were other legal circuits (with regard to the personality of the law) paying quite a lot of attention to the issue of reporting offences to an official authority. This issue is connected not only with the police regulations for the protection of the country, but is also strongly reflected in the set of provisions concerning the serfs.