bluuebunny/crossref_metadata_2025_split huggingface dataset:
Treatment with glatiramer acetate in APPswe/PS1dE9 mice at an early stage of Alzheimer’s disease prior to amyloid-beta deposition delays the disease’s pathological development and ameliorates cognitive decline
Authors: Huang Zengyong , Gong Zhuo , Lin Yongtai , Yang Fan , Chen Weiping , Xiang Shaotong , Huang Yuedong , Xiao Hao , Xu Shuwen , Duan Jinhai 
Published: January 2024

BackgroundAlzheimer’s disease (AD) is characterized by neuroinflammation, which is frequently accompanied by immune system dysfunction. Although the mechanism of neurodegenerative lesions is unclear, various clinical trials have highlighted that early intervention in AD is crucial to the success of treatment. In order to explore the potential of immunotherapy in the early period of AD, the present study evaluated whether application of glatiramer acetate (GA), an immunomodulatory agent approved for remitting–relapsing multiple sclerosis (RRMS), in the early stages of AD prior to amyloid beta (Aβ) deposition altered the Aβ pathology and cognitive impairments in APPswe/PSEN1dE9 (APP/PS1) transgenic mice.MethodsWe treated two cohorts of pre-depositing and amyloid-depositing (2- and 6-month-old) APP/PS1 mice with weekly-GA subcutaneous injection over a 12-week period. We then tested spatial learning and memory using the Morris water maze (MWM) and the Y maze. Immunohistochemistry staining was utilized to analyze Aβ burden in the brain as well as activated microglia. Furthermore, the inflammatory cytokine milieu within brains was estimated by quantitative real-time polymerase chain reaction, and the peripheral CD4+CD25+Foxp3+ regulatory T cells (Tregs) in the spleen were measured by flow cytometry.ResultsWe found that early GA administration reduced Aβ burden and ameliorated cognitive decline. Meanwhile, the immune microenvironment had changed in the brain, with an increase in the production of anti-inflammatory cytokines and a decrease in microglial activation. Interestingly, early GA administration also modulated the peripheral immune system through the amplification of Tregs in the spleen.ConclusionOverall, our findings revealed that GA treatment might enhance the central and peripheral immune systems’ protective capabilities in the early stages of AD, eventually improving cognitive deficits. Our research supports the advantages of immunomodulatory treatments for AD at an early stage.
Exercise intervention for the management of chemotherapy-induced peripheral neuropathy: a systematic review and network meta-analysis
Authors: Nakagawa Natsuki , Yamamoto Sena , Hanai Akiko , Oiwa Ayano , Arao Harue 
Published: January 2024

PurposeAlthough exercise is recommended for cancer survivors with chemotherapy-induced peripheral neuropathy (CIPN), the effective types of exercise for preventing and treating CIPN remain unclear. This systematic review and network meta-analysis (NMA) aimed to evaluate the comparative effects of exercise on CIPN.MethodsWe included relevant randomized controlled trials (RCTs) identified in a 2019 systematic review that evaluated the effects of exercise on CIPN and conducted an additional search for RCTs published until 2023. We evaluated the risk of bias for each RCT; the comparative effectiveness of exercise on patient-reported quality of life (QOL) through an NMA; and the effectiveness of exercise on QOL scores, patient-reported CIPN symptoms, and pain through additional meta-analyses.ResultsTwelve studies (exercise, n = 540; control, n = 527) comparing 8 exercise interventions were included in the analysis. All studies were determined to have a high risk of bias. The meta-analyses showed significantly improved QOL [standard mean differences (SMD) 0.45; 95% confidence interval (CI) = 0.12 to 0.78] and CIPN symptoms (SMD 0.46; 95% CI = 0.11 to 0.82). No severe adverse events were reported. Pain tended to improve with exercise (SMD 0.84; 95% CI = −0.11 to 1.80). An NMA suggested that the interventions of a combination of balance and strength training showed a significant improvement in QOL scores compared to the control.ConclusionExercise interventions may be beneficial for improving QOL and CIPN symptoms. High-quality large clinical trials and data are needed to conclude that exercise is beneficial and safe.
Where does the time go? Temporal patterns of pumping behaviors in mothers of very preterm infants vary by sociodemographic and clinical factors
Authors: Patel Aloka L. , Tan Amelia , Bucek Amelia , Janes Judy , McGee Katie , Mulcahy Delaney , Meier Paula , Johnson Tricia J. 
Published: January 2024

BackgroundMothers of very preterm (&lt;32 weeks gestational age [GA]) infants are breast pump dependent and have shorter duration of milk provision than mothers of term infants. The opportunity (i.e., time) cost of pumping and transporting mother’s own milk (MOM) from home to the NICU may be a barrier. There is a paucity of data regarding how much time mothers actually spend pumping.ObjectiveTo investigate the variation in pumping behavior by postpartum week, maternal characteristics, and infant GA.MethodsProspectively collected pump log data from mothers enrolled in ReDiMOM (Reducing Disparity in Mother’s Own Milk) randomized, controlled trial included pumping date and start time and end time of each pumping session for the first 10 weeks postpartum or until the infant was discharged from the NICU, whichever occurred first. Outcomes included number of daily pumping sessions, number of minutes spent pumping per day, and pumping behaviors during 24-h periods, aggregated to the postpartum week. Medians (interquartile ranges) were used to describe outcomes overall, and by maternal characteristics and infant GA.ResultsData included 13,994 pump sessions from 75 mothers. Maternal characteristics included 55% Black, 35% Hispanic, and 11% White and 44% &lt;30 years old. The majority (56%) of infants were born at GA 28–31 weeks. Mothers pumped an average of less than 4 times per day, peaking in postpartum week 2. After accounting for mothers who stopped pumping, there was a gradual decrease in daily pumping minutes between postpartum weeks 2 (89 min) and 10 (46 min). Black mothers pumped fewer times daily than non-Black mothers after the first 2 weeks postpartum.ConclusionOn average mothers pumped less intensively than the minimum recommendation of 8 times and 100 min per day. However, these pumping behaviors represent significant maternal opportunity costs that should be valued by the institution and society at large.
Enhancing the referral process for surgical management of spinal metastases: insights from a 12-year, bi-institutional study of 533 patients
Authors: Debono Bertrand , Perez Alexis , Lonjon Guillaume , Hamel Olivier , Dandine Jean-Baptiste , Dupuy Martin , Dutertre Guillaume , Braticevic Cécile , Latorzeff Igor , Amelot Aymeric 
Published: January 2024

IntroductionDelayed surgical management of spinal metastases (SMs) can have detrimental effects on patient survival and quality of life, leading to pain and potential neurological impairment. This study aimed to assess the impact of delayed referral for SMs on clinical outcomes by analyzing patients managed in emergency situations.MethodsWe retrospectively reviewed the data of all patients admitted on either emergency or elective basis who underwent surgery for the treatment of neoplastic spine lesions at our two institutions (tertiary referral neurosurgical units) between January 2008 and December 2019.ResultsWe analyzed 210 elective (EGp) and 323 emergency patients (UGp); emergencies increased significantly over the 12-year period, with a Friday peak (39.3%) and frequent neurological impairment (61.6% vs. 20%). Among the UGp patients, 186 (7.5%) had a previously monitored primitive cancer, including 102 (31.6%) with known SMs. On admission, 71 of the 102 (69.9%) patients presented with neurological deficits. UGp patients were more likely to undergo a single decompression without fixation. Outcomes at the 3-month follow-up were significantly worse for UGp patients ([very] poor, 29.2 vs. 13.8%), and the median overall survival for UGp patients was statistically lower. Risk factors for patients with SM undergoing emergency management included short delay between onset of symptoms and first contact with a spine surgeon, and an initial motor deficit.ConclusionMany patients with previously identified metastases, including those with neurological deficits, are urgently referred. Optimization is needed in the oncology pathway, and all stakeholders must be made aware of the factors contributing to the improvement in the clinical and radiological identification of potential complications affecting patient survival and quality of life.
Implementation of LGBTQ+ affirming care policies in the Veterans Health Administration: preliminary findings on barriers and facilitators in the southern United States
Authors: Singh Rajinder Sonia , Landes Sara J. , Willging Cathleen E. , Abraham Traci H. , McFrederick Pamela , Kauth Michael R. , Shipherd Jillian C. , Kirchner JoAnn E. 
Published: January 2024

BackgroundIn the United States Department of Veterans Affairs (VA), veterans who are lesbian, gay, bisexual, transgender, queer, and similar gender and sexual minoritized people (LGBTQ+) experience health disparities compared to cisgender, heterosexual veterans. VA’s LGBTQ+ Health Program created two healthcare policies on providing LGBTQ+ affirming care (healthcare that is inclusive, validating, and understanding of the LGBTQ+ population). The current project examines providers’ barriers and facilitators to providing LGBTQ+ affirming care and LGBTQ+ veterans’ barriers and facilitators to receiving LGBTQ+ affirming care.MethodsData collection and analysis were informed by the Consolidated Framework for Implementation Research, which was adapted to include three health equity domains. Data collection involved telephone interviews conducted with 11 VA providers and 12 LGBTQ+ veterans at one rural and one urban VA medical center, and one rural VA community clinic. Qualitative data were rapidly analyzed using template analysis, a data reduction technique.ResultsProviders described limited education, limited time, lack of experience with the population, and a lack of awareness of resources as barriers. Providers discussed comfort with consulting trusted peers, interest in learning more about providing LGBTQ+ affirming care, and openness and acceptance of the LGBTQ+ community as facilitators. LGBTQ+ veterans described a lack of provider awareness of their needs, concerns related to safety and discrimination, and structural discrimination as barriers. LGBTQ+ veterans described positive relationships with providers, knowledge of their own healthcare needs, and ability to advocate for their healthcare needs as facilitators. Although VA’s LGBTQ+ affirming care policies are in place, providers and veterans noted a lack of awareness regarding specific healthcare processes.ConclusionAllowing more time and capacity for education and engaging LGBTQ+ veterans in determining how to improve their healthcare may be the path forward to increase adherence to LGBTQ+ affirming care policies. Engaging patients, especially those from marginalized backgrounds, in strategies focused on the uptake of policy may be a path to improve policy implementation. It is possible that creating truly collaborative structures in which patients, staff, providers, leadership, and policymakers can work together towards policy implementation may be a useful strategy. In turn, improved policy implementation would result in increased physical and mental health for LGBTQ+ veterans.
Development of three-dimensional canine hepatic tumor model based on computed tomographic angiography for simulation of transarterial embolization
Authors: Oh Miju , Ban Jiyoung , Lee Yooyoung , Lee Minju , Kim Sojin , Kim Uhjin , Park Jiwoon , Han Jaepung , Chang Jinhwa , Kim Byungjin , Yun Hyeongrok , Lee Namsoon , Chang Dongwoo 
Published: January 2024

IntroductionTransarterial embolization (TAE) is one of the treatment options for liver masses that are not suitable for surgery and they have been applied in veterinary medicine for about 20 years, but surgical resection is considered as the first treatment option, and only a few case reports and articles about TAE in dogs have been published. Although understanding of vascular anatomy for the procedure is important, previous studies lack of the information about hepatic artery anatomy in small and toy-breed dogs. Due to the introduction of 3D print in veterinary medicine, it is now possible to make 3D models for preoperative planning. The purpose of this study is to understand the hepatic arterial vascular structure of various sizes and breeds of dogs, and to develop 3D-printed canine artery models with and without hepatic tumors to simulate TAE procedure.MethodsCT images of a total of 84 dogs with normal hepatic arteries were analyzed, and the mean value and standard deviation of body weight, celiac artery size, and hepatic artery size were 6.47 ± 4.44 kg, 3.28 ± 0.77 mm, and 2.14 ± 0.43 mm, respectively.ResultsIt was established that type 2-2-1, which has two separate hepatic branches—the right medial and left branch and the right lateral branch that runs to the right lateral lobe and caudate process—is the most prevalent of the hepatic artery branch types, as it was in the previous study. The review of 65 CT images of dogs with hepatic tumors showed that 44.6% (29/65) had multifocal lesions in multiple lobes, for which TAE can be recommended.DiscussionBased on the result, a 3D model of the normal canine hepatic artery and the hepatic tumor was made using one representative case from each group, and despite the models having some limitations in reflecting the exact tactile and velocity of blood vessels, TAE procedure was successfully simulated using both models.
Mutations administratives et formes nouvelles d’administration. Rapport introductif
Authors: Debbasch Charles 
Published: January 2024

Administrative changes and new forms of public administration

Because public administration is no longer merely the watchdog of society but has developed into an instrument for social change, it has lost its former clear-cut structure.
New forms of administration are developing outside of any preexisting framework. The expansion of such organisations is to be seen both in the diversity of their legal forms — either original in themselves or making use of existing legal structures outside of their original context — their geographical development and the variety of their areas of activity.
These new forms of administration have not grown up by chance or at the wish of a few administrative departments. Their proliferation is the evidence of the extent to which an attempt is being made to remedy some of the shortcomings of the traditional administrative System.
It is in fact an effort to create an administration better geared for action, doser to the public and more subject to central or local authority.
One irrefutable conclusion is obvious from this whole context of change : the uniformity of administrative structures no longer corresponds with the needs of society.
Rapport de Guy Braibant, Maître des requêtes au Conseil d’État
Authors: Braibant Guy 
Published: January 2024

Report by G. Braibant
A personal viewpoint on the problems which confront the administrative court judge, based on personal experience and written with the authority of someone who has published works on the subject of administrative law. The fact that the nature (both public and private) of many of these administrative bodies is not clearly defined has several drawbacks in that this makes difficult to ascertain applicable jurisdictional rules, results in a dissimilar legal status for such institutions and threatens to undermine the overall nature of the control traditionally exercised over public administration by the administrative judge. But the author is not content merely to State the facts — in this report he outlines the two main solutions which could be envisaged, i.e. either the adoption of a purely material or organic criterion or, on the other hand, the extension of the administrative judge’s control to ail administrative missions irrespective of what organisation Controls them.
Les structures des entreprises publiques
Authors: Delion André Georges 
Published: January 2024

Structures of public companies
All non-collectivist countries distinguish traditionally between two types of legal organisation, viz under public and under private law. As regards the first type, purely public law companies without legal capacity tend to disappear to the advantage of public institutions (etablissements publics), which in turn change gradually by taking over managerial structures or forms of management from the private sector, unless they do not become companies rightaway. There seems to be a general trend towards assuming statute law types of organisation considering that public companies depend ever more on central bodies or flrms, concerns, holdings, controlling “clusters” of subsidiaries. The public economy sector is hence taking on a new structure the main feature of which is the evolution towards 'public groups' . Here the development of a legal framework for the public company remains a delicate question, although some Latin-american countries and France work on it. The choice of structures has to respect a certain number of factors, such as convenience of management, type of tasks, technical and economic operating features, as well as national political options and problems of control. The author assesses in respect of each factor the various criteria to be taken into consideration to solve the problem of structural choice, of which the most prominent aspect is the need for constant adjustment. This need becomes in practice an issue of current management for the state and public groups.
Le financement des entreprises publiques
Authors: Vedel Georges 
Published: January 2024

Financing of public companies
The financing of public enterprise gives rise to a series of conflicts : yield capacity and requirements of public service, company targets and general policy goals of governments, control and autonomy. Theoretically, the matter has been dominated by the conclusions of the NORA report (April 1967).
The energy crisis was to change prospects thoroughly and frustrate the hopes put on the principles of self-financing, the implementation of which would have ruined the government’s efforts to check inflation. But though the ‘strategy’ of the Nora report was based on a given economie situation, it is less certain that the ‘doctrine’ is no longer applicable inasmuch as it tends above ail to enable decision-makers to choose in full clarity : transparency of resource allocation, clear distribution of responsibilities, uniform pattern of public company accounts.
Influence de la planification française dans les pays du tiers monde, depuis 1960
Authors: Franchet Yves , Winter Gérard 
Published: January 2024

The impact of French planning on Third World countries since 1960
Since the early 60’s, the impact of French planning on the Third World has passed through several stages, the first of which lasted for some ten years and was marked by the recognition of French thinking and experience in this field. A second stage of disillusionment followed with the growing awareness of both the importance of under-developmental problems and the specificity of developmental issues. After discussing these two stages, the author attempts to show that a third stage is shaping up which, in France, is intimately linked up with a new approach to planning. The third stage could be characterized by a convergent interest in planning taking a greater account of long term issues of a society whose needed changes have to be brought about under immediate exterior constraints
La gestion de la recherche au début des années 80 : problèmes et tendances
Authors: Ferné Georges 
Published: January 2024

Management of research in the early 80’s.
Ever since the early seventies a change in the conception of managerial policies for the research systems of industrialized countries has been observed. Government officiais no longer believe that «the researchers’curiosity » will direct spontaneously research towards attempts to provide a solution to specifie social or economie problems. The result has been an increasing trend towards planning and control of research and innovation procedures.
However the awareness is spreading that these efforts have shown their limits and that they involve certain dangers. Consequently, several countries have changed their approach by attempting to arrive at a better balance between central control and a certain autonomy left to those who carry out research. Therefore, new attempts have been recorded with a view to arriving at new decision-making modules for research policies.
Note introductive
Authors: Benedic Philippe 
Published: January 2024

Sistema tributario y política de desarrollo agrícola. Nota introductiva.
Presenta el autor una síntesis del sistema tributario agrícola en África, pasando de revista : la contribución directa, los impuestos indirectos y el problema de la fijación por el Estado de los precios de producción, para llegar a las conclusiones mayores siguientes :
En cuanto a la contribución directa, el rendimiento del impuesto territorial aún deja una gran margen de desarrollo dependiente por la mayoría de los casos de las opciones políticas de los Estados.
En lo que toca a los impuestos indirectos, la aplicación de tasas de salida a los productos de exportación procura una gran parte de los ingresos estatales.
La fijación de los precios al nivel de la producción constituye un instrumento portentoso para a la vez garantir al agricultor ingresos atrayentes, desarrollar la producción agrícola y regularizar las rentas públicas. Mas también es un instrumento que puede fácilmente desviarse de su objectivo inicial.
Panorama de la croissance économique des États africains, 1960-1977
Authors: Duverger Daniel 
Published: January 2024

Overview of economic growth trends in African States-1960-77.
The first two papers, discussing growth factors in African economies, arrive at similar conclusions through divergent analyses: the great variety of economic growth patterns, on the one hand and the sizable share of foreign trade and respective terms of trade in the growth of public revenue, on the other.
Les difficultés de la réforme fiscale : l’exemple du Pérou
Authors: Garelick Jacques 
Published: January 2024

Las dificultades de la reforma tributaria : el ejemplo del Perú.
En su papel sobre las dificultades de la reforma tributaria en el Perú, J. Garelick toca al problema de la compatibilitad de los imperativos financieros de la reforma con los objectivos políticos del gobierno, indicando toda una serie de obstáculos que había de vencer en su propósito de simplificar el sistema contributario.
L’administration locale et l’État-providence : les réformes structurelles et fonctionnelles opérées en Norvège depuis 1945
Authors: Kjellberg Francesco 
Published: January 2024

La administración local y el «estado-providencia» : reformas estructurales y funcionales en noruega desde 1945.
El autor hace un análisis de dos sobre las cuatro categorías de reforma realizadas en Noruega, a saber : reformas de estructura relativas a la división territorial y organización, y reformas de tipo funcional que tratan de la redistribución de competencias entre las autoridades administrativas centrales y locales. Pone de relieve en particular el carácter ambiguo de los procesos de reformas funcionales los cuales han encontrado viva resistencia por parte del sistema burocrático central.