bluuebunny/crossref_metadata_2025_split huggingface dataset:
Relationship of Albumin Levels, Comorbidity and Vaccination History with Mortality Of COVID-19 Patients in RSUP. H. Adam Malik Medan
Authors: Calandra Inez Vania , Sari Dina Keumala , Sinaga Bintang Yinke Magdalena 
Published: November 2023

<p><em>COVID-19 is a type of infectious disease caused by the SARS-CoV-2 virus. According to the results of previous studies, the risk factors for mortality in COVID-19 patients are often found in patients with low albumin levels, patients who have a history of comorbidities and patients who are not vaccinated. This study aims to determine the relationship between albumin levels, comorbidities and vaccination history with the mortality of COVID-19 patients in RSUP. H. Adam Malik Medan. This study used analytic observational with a cross-sectional approach carried out from June 2022-December 2020. Sample data were obtained from RSUP medical records. H. Adam Malik as many as 110 people. Sample data were analyzed using the Chi-Square statistical test. Subjects were male (53.64%), most subjects were ≥ 50 years old (80.91%), moderate subjects (55.45%), severe severity (24.55%) and critical severity (20%). The Chi-Square test showed that there was a significant relationship between albumin levels and mortality (0.003 &lt;0.05). There is no significant relationship between co-morbidities and mortality (0.141 &gt; 0.05). There is a significant relationship between vaccination history and mortality (0.002 &lt;0.05). There is a significant relationship between albumin levels and vaccination history with the mortality of COVID-19 patients in RSUP. H. Adam Malk Medan. Meanwhile, there was no significant relationship between comorbidities and mortality in COVID-19 patients at RSUP. H. Adam Malik Medan. Further research is needed to assess the factors that predict mortality in COVID-19 patients.</em></p><p><strong><em> </em></strong></p><strong><em>Keyword: Albumin</em></strong>, <strong><em>Comorbidities</em></strong>, <strong><em>Mortality, Vaccination</em></strong>
The Impact of Leadership and Communication on Safety Culture Maturity Level
Authors: Andelia Natasya , Silaban Gerry , Syahri Isyatun Mardhiyah 
Published: November 2023

<div><table cellspacing="0" cellpadding="0" align="left"><tbody><tr><td align="left" valign="top"><p><em>Safety culture is the way workers behave safely when working without supervision. In addition, five levels categorized into pathological, reactive, calculative, proactive, and generative levels are used to evaluate the level of safety culture maturity. This research aims to determine the influence of leadership and communication on the level of maturity of safety culture at the State Electricity Company Project Management Center-Construction Management Implementation Unit IV. The type of research used in this research is quantitative research with a cross sectional research design. The research will be carried out at the limited liability company national electricity company project management center-construction management implementation unit IV which operates in the field of construction management services. The research was conducted from March to August 2023. The sample collection technique was total sampling. The research sample was 71 respondents. The research instrument used was a questionnaire. Data analysis using SEM-PLS or Partial Least Square- Structural Equation Modeling analysis using SmartPLS software.</em><em> </em><em>The research results show that leadership has a significant effect on the level of safety culture maturity (p value &lt; 0.05), and communication has a significant effect on the level of safety culture maturity (p value &lt; 0.05). Leadership and communication simultaneously have a significant influence on the level of safety culture maturity, with a combined contribution of 70.7% from these two variables. Meanwhile, the rest is influenced by other variables not examined in this research.</em><em></em></p><p> </p></td></tr></tbody></table></div><p><strong><em>Keyword: Communication, Leadership, Safety culture maturity level</em></strong></p>
Modern Tacik Edebiyatının Kurucusu Sadreddin Aynî: Hayatı Eserleri ve Düşüncesi
Authors: ŞAFAK Turgay 
Published: November 2023

Modern Tacik edebiyatının kurucusu olarak kabul edilen Sadreddin Aynî Buhara’da dünyaya gelmiştir. Tarih, edebiyat, dilbilim, şiir ve sosyal eleştiri alanlarında eserler vermiştir. Ortaya koyduğu eserlerle Tacikistan ve Özbekistan’daki edebi, sosyal ve kültürel ortamın değişiminde büyük katkısı olmuştur. Buhara’da çiftçilik yapan bir ailede dünyaya gelen Sadreddin Aynî Buhara’da başlangıçta eğitim gördüğü Mir Arab medresesi dışında Alim Cân, Bedel Bey , Hacı Zâhid, Kökeldaş ve Hüseyin Bay gibi medreselerde ilim tahsil etmiştir. Buhara’daki entelektüel ve edebi ortamlarda yeni düşüncelerle tanışmıştır. Ceditçi aydınlarla birlikte Maarif hareketini başlatan kişiler arasında bulunan Aynî, Buhara’da cedit usulle açılan ilk mektep açıldığında eksikliğini görerek bu mektepler için ders kitapları da kaleme almıştır. Sadreddin Aynî’nin düşünce dünyasını etkileyen önemli unsurlardan biri dünyanın dört bir yanında neşredilen gazetelerdi. Özellikle İsmail Gaspıralı’nın Kırım’da neşredilen Tercüman gazetesi modern düşüncelerle tanışmasına vesile olmuştur. Telif ettiği eserler arasında tarih, edebiyat, biyografi, otobiyografi, hatırat ve şiirler vardır. Aynî Tacik dil ve edebiyatının müstakil bir edebiyat olduğunu ispat etmek için ciddi mücadeleler vermiş, bu yönde çeşitli kitaplar kaleme almıştır.
Bu makalede Türkiye’de hakkında bugüne kadar herhangi bir çalışma yapılmamış olan Sadreddin Aynî’nin hayatı eserleri ve düşünceleri ele alınmıştır. Birinci bölümde müellifin hayatı ele alınmıştır. İkinci bölümde temel düşünceleri, siyasi ve kültürel faaliyetleri ve etkileri hakkında bilgi verilmiştir. Üçüncü bölümde ise eserleri konularına göre tasnif edilerek tanıtılmıştır.
PERMANÊNCIA E ÊXITO SOB A PERSPECTIVA DISCENTE: ANÁLISE COM EGRESSOS E EVADIDOS DE CURSOS DO IFSC-TUBARÃO-SC
Authors: Corrêa Garcia Fernanda , Bortolanza Spessatto Marizete 
Published: November 2023

O presente artigo apresenta resultados de uma pesquisa que se propôs à investigação sobre as principais causas de evasão e retenção escolar – e na outra ponta, os fatores que mais contribuem para a permanência e êxito em cursos técnicos da Rede da Educação Profissional e Tecnológica (EPT). O tema é colocado em pauta desde os desdobramentos que acompanham a expansão da Rede EPT, incluindo-se entre eles as taxas de evasão e retenção. O trabalho parte do pressuposto de que as medidas a serem adotadas para assegurar a conclusão dos cursos técnicos – sejam eles integrados ou subsequentes – precisam considerar as especificidades de cada contexto regional e dos perfis dos sujeitos atendidos. Como delimitação metodológica, a pesquisa, de abordagem qualitativa, analisou a situação junto ao campus do IFSC de Tubarão, localizado na região sul de Santa Catarina. A pesquisa contemplou, a partir das vozes dos estudantes, o desenvolvimento de um Produto Educacional contendo ações práticas para atuação no combate da evasão e retenção. A análise aponta que os sentimentos de pertencimento e o foco dos cursos nas demandas do mundo do trabalho da região na qual os estudantes estão inseridos são os principais fatores para assegurar a permanência e o êxito.
Palavras-chave: Educação Profissional e Tecnológica. Permanência e Êxito. Evasão e Retenção. Produto Educacional.

ABSTRACT
This article presents the results of a research that aimed to investigate the main causes of school dropout and retention - and at the other end, the factors that most contribute to the permanence and success in technical courses of the Professional and Technological Education Network (EPT). The topic has been on the agenda since the developments that accompany the expansion of the EPT Network, including dropout and retention rates. The work assumes that the measures to be adopted to ensure the completion of technical courses, whether integrated or subsequent, need to consider the specifics of each regional context and the profiles of the subjects served. As a methodological delimitation, the research, with a qualitative approach, analyzed the situation near the IFSC campus in Tubarão, located in the southern region of Santa Catarina. The research contemplated, from the students' voices, the development of a Educational Product containing practical actions to act in the fight against dropout and retention. The analysis points out that the feelings of belonging and the focus of the courses on the demands of the world of work in the region in which the students are inserted are the main factors to ensure permanence and success.
Keywords: Professional and Technological Education. Permanence and Success. Evasion and Retention. Educational Product.
Knowledge and Role of Midwives in Using Maternal and Child Health Books
Authors: Pani Widya , Hasnawati Hasnawati 
Published: November 2023

Background The use of KIA books by midwives in Parigi Moutong Regency has not been optimal at around 82.1%, while those who do not use KIA books as much as 17.9% are due to the fact that at all times there is always a revision of the KIA book and there is no training in filling KIA books, only socializing Zoom Meetings and YouTube Channels, so many midwives still do not understand about filling it out, especially in the mother's section of the book. The purpose of this study is to determine the relationship between midwife's knowledge and the role of midwives in the use of KIA Books. The method is Cross cross-sectional approach, the population in this study is all Midwives in the Parigi Moutong Regency Area. The sample amounted to 83 respondents. The instrument used is a questionnaire—univariate and bivariate data analysis with a chi-square test. The study's results found that some respondents were well knowledgeable, 77 people (92.8%) and had good roles totaling 81 people (97.6%). With a p-value of ≤ 0.05 which is 0.004. The conclusion is that there is a relationship between midwives' knowledge and the role of midwives in the use of KIA Books in the Parigi Moutong Regency Area. It is expected for health workers, especially midwives, to motivate mothers more in terms of using KIA books.
Survival and prognostic factors of progressive multifocal leukoencephalopathy in people living with HIV in modern ART era
Authors: Jiang Rui , Song Zichen , Liu Li , Mei Xue , Sun Jianjun , Qi Tangkai , Wang Zhenyan , Song Wei , Tang Yang , Yang Junyang , Xu Shuibao , Zhao Bihe , Shen Yinzhong , Zhang Renfang , Chen Jun 
Published: November 2023

BackgroundThe incidence of progressive multifocal leukoencephalopathy (PML) in people living with HIV (PLWH) is 2%-4%. Currently, there is no effective therapeutic strategy for the treatment of PML in PLWH, resulting in a mortality of up to 50%. This study aimed to identify risk factors of death and prognostic markers in people living with HIV with PML.MethodsA retrospective cohort study of AIDS-related PML individuals was conducted from January 1, 2015, to October 1, 2022, in Shanghai, China. PLWH who were diagnosed with PML for the first time were included. Kaplan-Meier curve and Cox regression were used to analyze the survival and its predictors. Levels of inflammatory markers and immune checkpoint inhibitors in blood and cerebrospinal fluid (CSF) were measured in the prestored samples using bead-based multiplex assay Indolamine 2,3-dioxygenase was determined using ELISA.ResultsTwenty of 71 subjects had initiated antiretroviral therapy (ART) before PML onset and no patients discontinued ART during this period. In total, 34 patients (47.9%) had opportunistic infections (OIs), the median CD4+ T cell count was 73.0 (33.0-149.0) cells/μL. The estimated probability of survival at six months was 78% (95% confidential intervals [CIs]:0.63-0.85). OIs, low CD4+ T cell count were associated with lower estimated six-month survival (hazard ratio 8.01, 95% CIs: 1.80-35.00, P=0.006 and 5.01, 95% CIs:1.57-16.03, p=0.007). Indolamine 2,3-dioxygenase activity in CSF of non-survivors group were higher than survivors group (p&lt;0.05).ConclusionsThe survival rate of AIDS-related PML in the modern ART era was higher than the survival rate a decade ago. Low CD4+T cell count, OIs, were all associated with death of individuals with AIDS-related PML. The role of IDO in AIDS-related PML warrant further investigation.
An integrated methodological framework for the durable conservation of freshwater ecosystems: a case study in Colombia’s Caquetá River basin
Authors: Nogales Jonathan , Rogéliz-Prada Carlos , Cañon Miguel A. , Vargas-Luna Andres 
Published: November 2023

Introduction: Although freshwater ecosystems encompass 12% of all known species, their study has achieved less progress in systematic conservation planning exercises compared with terrestrial and marine ecosystems. Moreover, little attention has been given to ecosystem services and cultural and spiritual values, which are pivotal in the long-term preservation of freshwater ecosystems. Conservation, restoration, and sustainable management actions within freshwater systems are currently addressed individually, underscoring the necessity of comprehensive methodological frameworks that holistically address the questions of where and how to conserve while integrating ecosystem services and cultural factors as conservation values.Methods: We propose a new methodological framework for the conservation of freshwater ecosystems that incorporates these elements and fulfills six prioritization criteria: 1) representativeness, 2) integrity, 3) importance, 4) rarity, 5) complementarity, and 6) connectivity. To illustrate the application of this approach, we conducted a regional study in the Caquetá River basin in Colombia.Results: By applying our methodological framework, we demonstrated that the Caquetá River basin hosts 518 distinct freshwater groups with unique characteristics that contribute to the maintenance of ecosystems and the preservation of their inherent values. Additionally, our analysis revealed that protection is the most effective conservation strategy for 77.4% of the Caquetá River basin, whereas restoration and sustainable management are suitable for 4.7% and 17.9% of the basin, respectively. The prioritized portfolio for the Caquetá River basin encompasses 80.1% of all freshwater groups, effectively meeting The Nature Conservancy’s proposed conservation objectives.Conclusion: This novel methodological framework provides a pragmatic approach to systematic conservation planning and answers the questions of both where and how to conserve.
Fertility desire and associated factors among women of reproductive age living with HIV/AIDS attending antiretroviral therapy clinic in Arba Minch General Hospital, South Ethiopia, 2021
Authors: Tufa Disasa , Wassihun Biresaw , Misker Direslgne , Beyene Kassaw 
Published: November 2023

BackgroundThe fertility desire of women living with HIV to have children can have significant implications for public health. Despite the increase in the number of HIV-positive women, the issues of their fertility desire have not been well-studied. This study aims to assess fertility desire and associated factors among women living with HIV/AIDS.MethodsA facility-based cross-sectional study was conducted from 1 May to 30 July 2021. The researchers employed a systematic sampling technique. The data were gathered and entered into EpiData 3.1 software, and subsequently exported to the statistical package for social science version 25 for analysis. Binary logistic regression analyses were used to identify the factors involved, and a p-value of &lt;0.05 at a 95% confidence level was deemed to be statistically significant.ResultThe findings of this study indicate that 47.8% of women expressed a desire to conceive. Various factors such as parents’ pressure [adjusted odds ratio (AOR) = 4.41, 95% confidence interval (CI): 2.15–9.05], community pressure (AOR = 2.62, 95% CI: 1.30–5.26), being married (AOR = 0.25, 95% CI: 0.09–0.73), having only female offspring (AOR = 2.57, 95% CI: 1.12–5.90), and having HIV seropositive children (AOR = 2.45, 95% CI: 1.23–4.85) had statistically significant association with fertility desire.ConclusionThe study area exhibited a high level of fertility desire. Various factors can influence fertility desire, including parents’ pressure, community pressure, being married, having only female offspring, and having children who are HIV seropositive. When developing interventions on sexual and reproductive health issues, it is imperative for policymakers and healthcare providers who are working in antiretroviral therapy clinics to take into account the effects of these factors on women living with HIV. When designing and implementing prevention of mother-to-child transmission services, it is important to consider the fertility desires of mothers who are living with HIV.
Effects of human donor milk on gut barrier function and inflammation: in vitro study of the beneficial properties to the newborn
Authors: Rodríguez-Camejo Claudio , Puyol Arturo , Arbildi Paula , Sóñora Cecilia , Fazio Laura , Siré Gabriela , Hernández Ana 
Published: November 2023

IntroductionThe gastrointestinal and immune systems of premature infants are not fully developed, rendering them more vulnerable to severe complications like necrotizing enterocolitis. Human milk offers a rich array of bioactive factors that collectively contribute to reducing the incidence of gut infections and inflammatory conditions. When a mother's milk is unavailable, preterm infants are often provided with donor human milk processed in Human Milk Banks. However, it remains uncertain whether pasteurized milk confers the same level of risk reduction as unprocessed milk. This uncertainty may stem from the well-documented adverse effects of heat treatment on milk composition. Yet, our understanding of the comprehensive impact on protective mechanisms is limited.MethodsIn this study, we conducted a comparative analysis of the effects of raw versus pasteurized milk and colostrum versus mature milk on cellular functions associated with the gut epithelial barrier and responses to inflammatory stimuli. We utilized THP-1 and HT-29 cell lines, representing monocyte/macrophages and gut epithelial cells, respectively.ResultsOur observations revealed that all milk types stimulated epithelial cell proliferation. However, only raw colostrum increased cell migration and interfered with the interaction between E. coli and epithelial cells. Furthermore, the response of epithelial and macrophage cells to lipopolysaccharide (LPS) was enhanced solely by raw colostrum, with a milder effect observed with mature milk. In contrast, both raw and pasteurized milk diminished the LPS induced response in monocytes. Lastly, we examined how milk affected the differentiation of monocytes into macrophages, finding that milk reduced the subsequent inflammatory response of macrophages to LPS.DiscussionOur study sheds light on the impact of human milk on certain mechanisms that potentially account for its protective effects against necrotizing enterocolitis, highlighting the detrimental influence of pasteurization on some of these mechanisms. Our findings emphasize the urgency of developing alternative pasteurization methods to better preserve milk properties. Moreover, identifying the key components critically affected by these protective mechanisms could enable their inclusion in donor milk or formula, thereby enhancing immunological benefits for vulnerable newborns.
Parvalbumin-positive neurons in the medial vestibular nucleus contribute to vestibular compensation through commissural inhibition
Authors: Zhang Yuejin , Chu Guangpin , Leng Yangming , Lin Xueling , Zhou Hong , Lu Yisheng , Liu Bo 
Published: November 2023

BackgroundThe commissural inhibitory system between the bilateral medial vestibular nucleus (MVN) plays a key role in vestibular compensation. Calcium-binding protein parvalbumin (PV) is expressed in MVN GABAergic neurons. Whether these neurons are involved in vestibular compensation is still unknown.MethodsAfter unilateral labyrinthectomy (UL), we measured the activity of MVN PV neurons by in vivo calcium imaging, and observed the projection of MVN PV neurons by retrograde neural tracing. After regulating PV neurons’ activity by chemogenetic technique, the effects on vestibular compensation were evaluated by behavior analysis.ResultsWe found PV expression and the activity of PV neurons in contralateral but not ipsilateral MVN increased 6 h following UL. ErbB4 is required to maintain GABA release for PV neurons, conditional knockout ErbB4 from PV neurons promoted vestibular compensation. Further investigation showed that vestibular compensation could be promoted by chemogenetic inhibition of contralateral MVN or activation of ipsilateral MVN PV neurons. Additional neural tracing study revealed that considerable MVN PV neurons were projecting to the opposite side of MVN, and that activating the ipsilateral MVN PV neurons projecting to contralateral MVN can promote vestibular compensation.ConclusionContralateral MVN PV neuron activation after UL is detrimental to vestibular compensation, and rebalancing bilateral MVN PV neuron activity can promote vestibular compensation, via commissural inhibition from the ipsilateral MVN PV neurons. Our findings provide a new understanding of vestibular compensation at the neural circuitry level and a novel potential therapeutic target for vestibular disorders.
Dietary and lifestyle factors associated with troublesome gastroesophageal reflux symptoms in Vietnamese adults
Authors: Quach Duc Trong , Luu Mai Ngoc , Nguyen Phong Van , Vo Uyen Pham-Phuong , Vo Cong Hong-Minh 
Published: November 2023

BackgroundDietary and lifestyle habits related to troublesome gastroesophageal reflux symptoms (tGERS) differ significantly across populations. There have yet to be studies on the Vietnamese population.AimsTo identify dietary and lifestyle habits associated with tGERS in Vietnamese adults.MethodsA cross-sectional survey was conducted among Vietnamese adults aged 18 years and older from March 2023 to May 2023. Participants were recruited online through a widely read national newspaper and Facebook, one of Vietnam’s most popular social media platforms. The survey questionnaire comprised 27 questions covering participants’ basic demographic information, dietary and lifestyle habits, the presence and characteristics of tGERS, and inquiries about specific dietary and lifestyle patterns, foods, and beverages associated with tGERS.ResultsA total of 4,400 valid responses were collected, including 2050 participants without tGERS and 2,350 participants with tGERS. Multivariate analysis showed several factors associated with tGERS, including eating beyond fullness (OR 1.383, CI95% 1.127–1.698), tight clothing (OR 1.627, CI95% 1.256–2.107), stress (OR 1.566, CI95% 1.363–1.800), and insomnia (OR 1.321, CI95% 1.129–1.546). Among habits associated with tGERS, eating beyond fullness was the most frequently reported (64.6%). Interestingly, although a short meal-to-bed time and staying up late after midnight were not risk factors for tGERS, they were two common factors associated with tGERS in symptomatic participants, particularly those with nocturnal reflux symptoms. For food triggers, the three most common ones were greasy foods (71.9%), sour/spicy soups (64.7%), and citrus fruits (36.0%). In terms of beverages, carbonated soft drinks were at the top of triggering tGERS (40.3%), and beer and orange juice were the second and third most common triggers, accounting for 35.7 and 30.6%, respectively.ConclusionWe reported the dietary and lifestyle habits associated with tGERS in Vietnamese adults for the first time. These findings will serve as a basis for future studies on the primary prevention and nondrug management of tGERS in Vietnam.