bluuebunny/crossref_metadata_2025_split huggingface dataset:
Qualitative research methods in studying the problems of adult population vaccination: relevance and design
Authors: Lopatina M. V. , Krieger E. A. , Kudryavtsev A. V. , Yakovleva V. A. , Nizovtseva T. R. , Kontsevaya А. V. , Drapkina O. M. 
Published: February 2024

Vaccination is an effective tool to control infectious diseases at the population level. There is an increase in the proportion of the adult population vulnerable to controlled infections, which is confirmed by the emergence of disease outbreaks involving population aged >18 years. Qualitative research methods are used to explore factors influencing vaccination behavior.Aim. To develop and present a qualitative study design to study barriers and drivers for vaccination in adults.Material and methods. The World Health Organization (WHO) approach of Tailoring Immunization Programs (TIP), Capability-Opportunity-Motivation-Behavior (COM-B) tool, developed by the WHO and adapted in several countries to study vaccination issues, and the Rapid Assessment Process method were chosen and adapted for conducting a study in three Russian regions. The qualitative methods selected are focus groups and in-depth personal interviews in two target groups of adults and medical workers. A purposive sampling method will be used to select population participants aged ≥18 years.Results. A qualitative research design was developed, including the following steps: selecting target populations, developing a discussion plan, training the analytical group, testing the methodology and questions in the target groups, collecting and analyzing data, developing recommendations and interventions.Conclusion. Qualitative research methods are preferable for identifying vaccination barriers and drivers. Based on the results obtained, an educational program for health workers will be developed, including communicating approaches to be used with patients when discussing vaccination matters.The qualitative research design developed and presented can be used by researchers, public health professionals, and decision-makers to study vaccination behavior among adults.
Associations of the density and proximity of the outlets of tobacco and other nicotine-containing products with increased levels of depression, anxiety and stress among the population of 3 Russian regions
Authors: Gambaryan M. G. , Kontsevaya A. V. , Antsiferova A. A. , Mukaneeva D. K. , Kutsenko V. A. , Pustelenin N. A. , Khudyakov M. B. , Kudryavtsev A. V. , Filichkina E. M. , Glukhovskaya S. V. , Solovyova A. V. , Shalnova S. A. , Balanova Yu. А. , Imaeva A. E. , Drapkina O. M. 
Published: February 2024

Aim. To study the relationship of the density and proximity of tobacco products (TPs) and electronic nicotine delivery systems (ENDS) with increased levels of depression, anxiety and stress among the population in 3 constituent entities of the Russian Federation.Material and methods. The work used data from the Epidemiology of Cardiovascular Diseases and their Risk Factors in Regions of Russian Federation-3 (ESSE-RF3) study in 3 Russian regions (Arkhangelsk, Sverdlovsk and Tver regions) among the population aged 35-64 years (n=1674), who signed a consent to participate in the study. We analyzed data on the status of smoking and consumption of ENDS, passive smoking, attempts to quit smoking, as well as the presence of depression, anxiety (Hospital Anxiety and Depression Scale (HADS) score ≥8) and stress (Perceived Stress Scale (PSS) >21). Elements of urban infrastructure (data collection: January-March 2022) selling TPs and ENDS were assessed using aт OpenStreetMap-based program. Associations were established using logistic regression analysis.Results. With a twofold increase in the distance of TP and ENDS outlets from the place of residence, the depression probability was reduced by 13% (odds ratio (OR) 0,87; 95% confidence interval (CI): 0,79-0,96) and by 12% (OR 0,88; 95% CI: 0,78-0,99), respectively. With increase in distance from of TP outlets, the anxiety decreased probability by 12% (OR 0,88; 95% CI: 0,81-0,97). With an increase in the number of TP outlets within a radius of 1000 m from the place of residence, there were an increase in the probability of depression (OR 1,18; 95% CI: 1,031,36), anxiety (OR 1,12; 95% CI: 1-1,26) and stress (OR 1,24; 95% CI: 1,05-1,46). A greater number of ENDS outlets within a radius of 1000 m and 400 m was associated with a high likelihood of depression (OR 1,17; 95% CI: 1,02-1,34 and OR 1,25; 95% CI: 1,04-1,47, respectively). An increased depression probability was found in those exposed to tobacco smoke at home (OR 1,88; 95% CI: 1,27-2,73) and at work (OR 1,67; 95% CI: 1,14-2,41). An increase in the number of attempts to quit smoking doubles the odds of depression (OR 2,40; 95% CI: 1,35-4,23) and anxiety (OR 2,00; 95% CI: 1,18-3,38).Conclusion. Unfavorable environmental factors, including the proximity and density of TP and ENDS outlets, can increase the probability of depression, anxiety and stress among the population living in these areas.
Genetic aspects of decreased low-density lipoprotein cholesterol values
Authors: Meshkov A. N. , Ershova A. I. , Kiseleva A. V. , Mikhailina V. I. , Smetnev S. A. , Soplenkova А. G. , Kutsenko V. A. , Sotnikova Е. A. , Vyatkin Yu. V. , Zharikova A. A. , Zaichenoka M. , Ramensky V. E. , Skirko O. P. , Pokrovskaya M. S. , Litinskaya O. A. , Shalnova S. A. , Drapkina O. M. 
Published: February 2024

Aim. To study genetic causes of decreased low-density lipoprotein cholesterol (LDL-C) in Russian patients.Material and methods. The study included the following Epidemiology of Cardiovascular Diseases and their Risk Factors in Regions of Russian Federation (ESSE-RF) participants: individuals with LDL-C<5th percentile, taking into account sex and age (n=52), who underwent targeted sequencing of protein-coding regions of 6 genes (APOB, PCSK9, MTTP, ANGPTL3, SAR1B, APOC3) and determination of the genetic risk score (GRS) for hypercholesterolemia; and a representative sample of the Ivanovo region population (ESSEIvanovo, n=1667), for which only GRS was determined. Genetic testing was performed using next generation sequencing.Results. In 10 (19,2%) of 52 participants with decreased LDL-C levels, the following rare variants potentially associated with hypocholesterolemia were identified: 8 — leading to a premature termination codon in the APOB gene, 1 — leading to a premature termination codon in the APOC3 gene and 1 missense variant in the PCSK9 gene. Of the 10 identified variants, 6 are described by us for the first time. GRS in the LDL-C group (0,27±0,25) was significantly lower than in the ESSE-Ivanovo population sample (0,43±0,27) (p=4,7×10-06).Conclusion. Genetic reasons explain decreased LDL-C levels (<5th percentile) in 32,7% of patients, of which only monogenic variants were identified in 13,5%, a combination of monogenic and polygenic hypocholesterolemia — in 5,7%, and polygenic hypocholesterolemia — in 13,5%.
Resection of tumors of the cranial bones with single-step defect reconstruction using a personalized implant
Authors: Yashin K. S. , Zinatullin R. D. , Bratsev I. S. , Dubrovskiy D. V. , Ermolaev A. Yu. , Ostapyuk M. V. , Kutlaeva M. A. , Rasteryaeva M. V. , Medyanik I. A. , Kravets L. Ya. 
Published: February 2024

Background. In patients with skull bone tumors, it was demonstrated that not only the oncological but also the cosmetic result has a significant influence on the long-term outcome. The traditional approach to the surgical treatment of tumor lesions of the skull bones is removal of the tumor and intraoperative modeling an artificial bone flap without a template. Recently, the technology of simultaneous resection and computer-aided design/computer-aided manufacturing (CAD/CAM) cranioplasty has received more and more attention.Aim. To compare the results of surgical treatment of patients with tumors of the cranial bones using the traditional approach (intraoperative formation of a plate to close the defect) and simultaneous resection followed by plastic surgery of the defect with a personalized implant made using preoperative virtual modeling.Materials and methods. The study included 24 patients with tumors of the skull or meningiomas with extracranial growth. Depending on the surgical procedure, patients were divided into 2 groups: group 1 (n = 13) – the technology of simultaneous resection and CAD/CAM cranioplasty; group 2 (n = 11) – where surgery was performed using a traditional approach based on intraoperative modeling an artificial bone flap without a template.Results. There were no statistically significant differences between groups in gender, age, time of surgery, blood loss, or time in hospital. The use of simultaneous resection and CAD/CAM cranioplasty did not demonstrate a statistically significant better result in terms of maintaining skull symmetry compared to the traditional approach. All patients had a good cosmetic result and there were no complications.Conclusion. The technology of simultaneous resection and CAD/CAM cranioplasty is an effective method of treating patients with neoplasmas of the skull bones. Despite the absence of statistically significant differences in the results of treatment of cranial bone tumors between this method and the traditional approach based on intraoperative modeling an artificial bone flap without a template this method seems to be a more precise providing the best cosmetic effect in patients with lesion in fronto-orbital region.
Implementação de práticas avançadas de enfermagem no enfrentamento do atraso vacinal: relato de experiência
Authors: Maciel Ana Paula Ferreira , Soares Raquel Gusmão , Moreira Kênia Souto , Versiani Claudia Mendes Campos , Santos Viviane Maia , Braz Patrícia Pereir Alves , Guedes Ana Beatriz Mota , Silva Carla Silvana Oliveira e 
Published: February 2024

Objetivo: Descrever a implementação de práticas avançadas de enfermagem como enfrentamento do atraso vacinal de crianças menores de dois anos de idade. Método: Trata-se de um relato de experiência, onde foi feita a monitorização da situação vacinal de crianças com menos de dois anos de idade bem como a descrição de práticas avançadas de enfermagem para melhoria da adesão vacinal. Resultados: Foi realizado o monitoramento vacinal das crianças e realizadas ações e intervenções individuais e coletivas, como: atendimentos individuais, buscas ativas, chamadas via telefone e mensagens via aplicativo de celular, educações permanentes e confecção de materiais educativos para sensibilização de comunidade, pais/responsáveis e profissionais de saúde para a importância de manter o calendário vacinal em dia, conforme proposto pelo Programa Nacional de Imunização. Conclusão: As ações deste relato demonstraram implicações importantes para a saúde pública podendo sugerir que práticas avançadas de enfermagem impactam positivamente para a melhoria das coberturas vacinais.
TISSUE ENGINEERING MATRIX BASED ON POLYURETHANE: IN VITRO RESEARCH
Authors: Senokosova Evgenia A. , Prokudina Ekaterina S. , Matveeva Vera G. , Velikanova Elena A. , Glushkova Tatyana V. , Koshelev Vladislav A. , Akentyeva Tatyana N. , Antonova Larisa V. , Barbarash Leonid S. 
Published: February 2024

HighlightsThe article focuses on a new polyurethane-based material that has been developed and tested in vitro. This highly porous material with satisfactory physical and mechanical, hemocompatibility and matrix properties, obtained by using an electrospinning method, is suitable for the fabrication of cardiovascular products. AbstractAim. To manufacture a polyurethane-based tissue engineered matrix and study its physical and mechanical characteristics, hemocompatibility and matrix properties in comparison with decellularized xenopericardium and sheep carotid artery.Methods. Matrices based on polyurethane were produced by electrospinning. The surface structure was studied by scanning electron microscopy, the physical and mechanical characteristics were studied using a Zwick/Roell Universal testing machine, hemocompatibility was studied according to ISO 10993-4-2020, and the matrix properties of the material were studied in a cell experiment with Ea.hy 926.Results. The structure of the 12% polyurethane matrix was represented by a fibrous network with interpenetrating pores. The physical and mechanical characteristics of polyurethane matrices corresponded to the parameters of the carotid artery of sheep more than xenopericardium. Polyurethane had optimal hemocompatibility: hemolysis of erythrocytes did not exceed 0.52%, platelet aggregation corresponded to the aggregation of platelet-rich plasma – 80%. Platelet adhesion to the surface of the polyurethane matrix is statistically significantly lower than adhesion to the xenopericardium (p = 0.0041). Cell adhesion, viability and metabolic activity of Ea.hy 926 cultured on the surface of polyurethane matrices were higher relative to xenopericardium: cell density was 236.3 [198.5; 264.6] cells/mm2 (p = 0.458), viability 19.0 [16.0; 25.0] % (p = 0.0145).Conclusion. Physical and mechanical characteristics, hemocompatibility and matrix properties of polyurethane confirmed its suitability for potential use for the needs of cardiovascular surgery.
IMMUNOINFLAMMATORY PROCESSES IN THE PATHOGENESIS OF ATHEROSCLEROSIS
Authors: Mordovin Victor F. , Zyubanova Irina V. , Manukyan Musheg A. , Tsoi Ekaterina I. , Falkovskaya Allа Yu. 
Published: February 2024

HighlightsThe article describes the main pathogenetic aspects of atherogenesis and focuses on the role of low-intensity inflammation in this process. Moreover, the article presents data on the possibilities of predicting cardiovascular outcomes in patients using a number of pro-inflammatory markers, and on the effectiveness of anti-inflammatory therapy in this cohort of patients. AbstractChronic low-intensity inflammation is currently considered one of the most significant risk factors for cardiovascular disease. The initiation and progression of atherosclerosis are associated with an inflammatory response to endothelial damage, accompanied by an increase in number of pro-inflammatory markers blood circulation. The atherogenic effect of the main risk factors for atherosclerosis, such as hypertension, smoking, increased dietary fat intake, physical inactivity and obesity, as well as psychological and emotional factors and sleep disturbance, is mostly carried out through these mechanisms. In addition, proinflammatory cytokines blood levels increase is associated with sympathetic tone level increase under these risk factors influence.The article describes the relevant atherogenesis mechanisms and the results of large clinical trials studying the relationship between inflammatory activity, assessed by the levels of various pro-inflammatory markers, and the risk of cardiovascular complications. Data regarding the use of anti-inflammatory drugs such as canakinumab, anakinra, tocilizumab, colchicine to treat patients with coronary artery disease are given. The efficacy of nano-immunotherapy, when powerful anti-inflammatory agents are target delivered to atherosclerotic plaques using nanoparticles, is considered, as well as the anti-inflammatory effect of renal denervation due to the sympatholytic activity of this procedure.
THE PROBLEM OF TRANSCATHETER CLOSURE OF MULTIPLE ATRIAL SEPTAL DEFECTS: INTERVENTIONAL APPROACHES AND RESULTS. LITERATURE REVIEW
Authors: Troshkinev Nikita M. , Tarasov Roman S. 
Published: February 2024

HighlightsThe article presents a review of the literature and the results of endovascular correction of multiple atrial septal defects, methods of occluder implantation. Indications for transcatheter closure and possible complications of the procedure are given. AbstractOver the past few decades, the treatment strategy for the second atrial septal defect has changed significantly. Due to the improvement of device technology and procedural techniques, transcatheter closure of atrial septal defects is currently considered to be the method of choice in most patients with secondary types of defects. The latest generation devices provide a simple and safe implantation. The use of biocompatible occluder materials contributes to endothelization and reduction of traumatization of nearby structures. Most of the currently available devices demonstrate excellent efficiency and comparable results with their own advantages and disadvantages. In addition to improving the properties and performance of the device, there was a clear improvement in the procedural technique because of numerous experiments with closing of the device. A difficult problem for an endovascular surgeon is the procedure for closing multiple defects, due to their shapes, locations on the septum, the lack of a sufficient amount of tissue edge on the septum, as well as difficulties with choosing the type of device, their number and relative location.
BIOPROSTHETIC VALVE IMPLANTATION AS TYPE OF TRANSPLANTATION: IMMUNOLOGICAL CONSEQUENCES OF NEW CONCEPT
Authors: Kostyunin Alexander E. , Glushkova Tatiana V. , Ovcharenko Evgeny A. 
Published: February 2024

HighlightsImmune processes and mechanisms underlying bioprosthetic heart valve degeneration and rejection of allografts and xenografts are similar.Manufacturers and surgeons can implement effective approaches to prevent immune rejection in the process of production and implantation of prosthetic heart valves in order to delay the process of structural valve degeneration. AbstractBioprosthetic heart valves (BHV) are characterized by low thrombogenicity, thus circumventing the need for long‐term anticoagulation. However, BHV lifespan is limited to 10–15 years because its tissue components are subject to degeneration. Recent research data indicate that immune responses forming the basis of humoral and cellular rejection of allografts and xenografts play a major role in the development of structural valve degeneration (SVD). This review summarizes up-to-date data on immune processes involved in SVD pathogenesis. Moreover, the latest achievements in the development of strategies to reduce the immunogenicity of BHV, such as data on immune compatibility of allogeneic material and the process of deriving low immunogenic biomaterial from genetically modified animals, decellularization of BHV, and the ways of slowing the process of degeneration are analyzed.
PREVALENCE OF PRE-FRAILTY AND FRAILTY IN PATIENTS WITH MULTIVESSEL CORONARY ARTERY DISEASE
Authors: Krivoshapova Kristina E. , Tsygankov Denis A. , Tsygankova Daria P. , Barbarash Olga L. 
Published: February 2024

Highlights The article is focused on one of the most urgent modern issues – the peculiarities of the diagnosis of pathological aging. Due to the absence of a “gold standard” of detection of frailty, attempts to assess its prevalence among the population of different age groups present fragmented and controversial data. In this study, for the first time, the prevalence of frailty in patients with multivessel coronary artery disease, characterized by extremely pronounced clinical complexity, was analyzed using six different diagnostic approaches, allowing us to obtain data on the sensitivity and specificity of these instruments. AbstractAim. To study the prevalence of pre-frailty and frailty in patients with multivessel coronary artery disease.Methods. The study included 387 patients with multivessel coronary artery disease scheduled for coronary artery bypass grafting. To detect pre-frailty and frailty, we have used various diagnostic approaches, such as the screening questionnaire “Age is not a drawback”, a multi-stage diagnostic framework based on the clinical recommendations on frailty developed by the “Russian Association of Gerontologists and Geriatricians” in 2020, the questionnaire “PRISMA-7”, the clinical frailty scale, the criteria of the Fried frailty phenotype, and the modified 5-item frailty index (mFI-5).Results. The median age was 65 [59; 69] years, men were the majority (73.1%). Taking into account six diagnostic approaches, the prevalence of frailty in patients with multivessel coronary artery disease varied from 19.1% to 71.6%, the prevalence of pre-frailty varied from 15% to 58.2%. A high number of patients with frailty was detected using a multi-stage diagnostic framework based on the on the clinical recommendations on frailty developed by the “Russian Association of Gerontologists and Geriatricians” (46.8%), the clinical frailty scale (44.5%), the criteria of the Fried frailty phenotype (42.4%) and mFI-5 (71.6%), the lowest number of patients with frailty was detected using the questionnaire “PRISMA-7” (22.5%). The clinical frailty scale showed a higher level of sensitivity and specificity (67.8% and 80%, respectively) regarding the detection of pre-frailty, whereas a multi-stage diagnostic framework had a higher level of sensitivity and specificity (65.2% and 76.8%, respectively) regarding the detection of frailty.Conclusions. The results of the study revealed a high prevalence of pre-frailty (15–58.2%) and frailty (19.1–71.6%) in patients with multivessel coronary artery disease, taking into account several diagnostic approaches. The clinical frailty scale and a multi-stage diagnostic framework based on the recommendations showed the highest sensitivity and specificity regarding the detection of frailty (clinical frailty scale – 67.8% and 80%, respectively; a multi-stage diagnostic framework – 65.2% and 76.8%, respectively).