bluuebunny/crossref_metadata_2025_split huggingface dataset:
Revolutionizing Oral Cancer Care: The Therapeutic Potential of
Coenzyme Q10 and Balanced Trace Metals
Authors: Baloch Saeeda Rind , Memon Ayaz Ali , Khan Wasid Ullah , Sanjrani Manzoor Ahmed , shah Komal 
Published: January 2025

Aims:
This case-control study compared the concentrations of coenzyme Q10 in plasma
and various trace elements from serum isolated from a patient with oral cancer to those of healthy
people

Background:
Oral cancer is a severe and progressive disease related to metabolic disorders and oxidative stress challenges. Impaired in CoQ10, an essential component of the mitochondrial electron
transport chain antioxidant. CoQ10, a major scavenger of free radicals, protects mitochondria against
oxidative stress. Trace elements, such as Na+
, Fe2+, Zn, and Ca2+, are also crucial regarding physiological functions and normal metabolic pathways, including cancer hallmarks.

Objectives:
The study aimed to assess CoQ10 and trace metals in patients with oral cancer at various
stages and compare them with healthy subjects. The current study deals with metabolic alterations
that occur as oral cancer grows to enhance knowledge and potential therapeutic intervention paths.

Methods:
Analysis of CoQ10 and trace element: HPLC-DAD Metal concentrations in serum were
measured using ICP-OES). 55 oral cancer patients and 30 healthy individuals were recruited for
blood collection. The patients were diagnosed as T1N1, T2N2 PT3 N1M8, and T4N. Study duration
2 months. Which includes patients' sex, age, habits, diet, physical characteristics, race, habits, and
chronic illness.

Results:
As cancer stages increased, CoQ10 levels continuously decreased from 0.5-1.26 mg/L from
stage I to 0.6-2.8 mg/L to stage IV. Eight different trace elements, Na+
, Fe2+, Zn+, and Ca2+, have
levels across different stages of cancer with no discernible change. In healthy individuals, the CoQ10
level changed from 1.43 to 1.67 mg/L, showing age decline.

Conclusions:
This study is the first to report a statistically significant reduction in CoQ10 levels
related to the stages of oral cancer. In contrast, trace metal levels were kept almost constant. The
findings conclude that the observed CoQ10-associated defects or deficiencies in oral cancer patients
help to explain a potential cause of metabolic changes relevant to carcinogenesis. These insights are
probably potential therapeutic targets for the manipulation of CoQ10 levels and support from supplements retention/balance essential metals, such as cancer care.
Role of Liposomes in the Treatment of Neurodegenerative Disorders: A Comprehensive Review
Authors: Garg Nitika , Dhankhar Sanchit , Dhariya Ankush , Parkash Chander , Chauhan Samrat , Singh Thakur Gurjeet 
Published: January 2025

Abstract:
The complex etiology and limited therapy options of neurodegenerative illnesses pose
daunting challenges to modern medicine. Nonetheless, novel treatment approaches have exciting
new possibilities because of developments in nanotechnology. Liposomes have garnered a lot of
interest as a potential treatment for neurological illnesses due to the fact that they are able to adapt
to their role as nanocarriers. This review article discusses various uses of liposomes, including
their ability to help treat neurodegenerative diseases such as Alzheimer's, Parkinson's, and Huntington's
disease, as well as their diagnostic and neuroprotective uses. Liposomes allow for the targeted
delivery of medicines to specific brain areas with minimal systemic side effects since they
encapsulate and carry therapeutic molecules across the blood-brain barrier. Due to the fact that
they are biocompatible, have surface features that can be adjusted, and have the ability to co-deliver
many drugs, liposomes are excellent candidates for combination therapy and personalized
medicine procedures. In spite of this, there is a growing body of research that suggests liposomes
could serve as a versatile platform for the improvement of neurodegenerative disease treatment.
This is a positive sign for the future results of patients and their quality of life.
Low-dose Systemic Tissue-type-plasminogen-activator Compared to Conventional
Anti-coagulation for the Treatment of Intermediate-high Risk
Pulmonary Embolism
Authors: Rosa Alan De la , Murguia Adrian Rojas , Brockman Michael J , Mukherjee Debabrata , Rajachandran Manu , Nickel Nils P 
Published: January 2025

Background:
Pulmonary embolism (PE) is a frequent cause of death. Acute PE may be
treated either with full anticoagulation (AC) alone or thrombolytic therapy with systemic tissue--
type-plasminogen-activator (tPA) based on risk assessment. Currently, AC is the standard of care
for most patients with intermediate-high-risk PE, with low-dose tPA emerging as an effective alternative.
However, studies directly comparing the efficacy and safety of low-dose tPA to AC are
lacking in this patient population.

Objective:
The aim of this study was to retrospectively compare the efficacy and safety of low--
dose tPA, compared to AC alone in right ventricular function and in-hospital mortality and bleeding
complications in patients presenting with intermediate-high risk PE.

Methods:
This is a single-center, retrospective cohort trial conducted at a university hospital. A total
of 148 patients were screened, and 88 patients qualified for this study. The primary endpoints
were changes in right ventricular function on echocardiogram in 24 hours, in-hospital mortality,
and major bleeding complications.

Results:
Eighty-eight consecutive patients with intermediate high-risk PE were included. Twenty-
six patients (29.5%) received low-dose systemic tPA administered via intravenous infusion,
and 62 patients (70.4%) received standard full-dose anticoagulation. There were no significant differences
in baseline vital signs or PESI scores between the low-dose tPA and the AC group. Patients
in the low-dose tPA group had worse RV function and higher troponin levels at baseline but
showed significant improvement in all RV parameters assessed during the 24-hour follow-up. In
comparison, there was no significant improvement in RV function in the AC group. There were
more bleeding events in the AC group. LOS was shorter in the low-dose tPA group.

Conclusion:
Treatment with low-dose prolonged infusion of tPA may be an effective and safe
therapy in patients with intermediate-risk PE. Compared to AC, low-dose tPA was effective in decreasing
PASP and restoration of RV function.
A State-Of-Art Review on One-Step Microwave Green Synthesis of Silver Nanoparticles and their Biological Applications
Authors: R. Venkataraghavan , K. Chithra , J. Sreeram K. 
Published: January 2025

Abstract:
Silver-based nanoparticles (AgNps) have recently gained traction for versatile applications
in biotechnology. However, selecting the suitable synthesis method remains a challenge, as
current techniques often suffer from slow reaction rates, high costs, low efficacy, and limited reproducibility.
Therefore, it is deemed necessary to choose a method that will offer furtherance of the
current technologies to address these drawbacks. One promising approach is microwave (MW) irradiation,
which is a one-step, simple, cost-effective, reproducible, and sustainable than conventional
methods. MW irradiation enables the rapid formation of highly stable nanoparticles as small
as ~2 nm, achieving energy savings of up to 70%. Additionally, using biological agents as reducing
agents in MW-assisted synthesis promotes an eco-friendly, low-cost, and straightforward approach.
This critical review presents the mechanism behind various biological applications and their efficiencies,
anticipating research toward synthesizing high-quality nanoparticles. It encourages adapting
the use of MW technology for the facile synthesis of high-quality metal and metal oxide nanoparticles,
providing a new way for sustainable applications.
A Qualitative Study of Migrant Family Experiences during the COVID-19 Pandemic in Spain
Authors: Andrade Alejandra Salazar , Roca Josefina Sala , Pérez Sara Rodríguez 
Published: January 2025

Background
The COVID-19 pandemic stemming from the global contagion of the respiratory virus first identified in 2019, now ongoing for four years, impacted the world in different ways that are important to understand for its short and long-term mental health risks. This study aims to examine the experiences of migrant families in Spain as a vulnerable cluster, identifying the characteristics under which they had to adapt in Spain, affecting their psychological well-being.

Methods
This research used a qualitative research design to explore the experiences of the families during the pandemic, during closures, and after the quarantine was lifted in Spain. Semi-structured interviews were conducted with a child and a parent of 17 migrant families.

Results
The key themes that emerged from the interviews with this sample’s experiences regarding their life during the pandemic were social isolation, routine interruption, economic difficulties, and bureaucratic obstacles that ensued from public health restrictions. This indicated potential risks to the families’ psychological well-being and their mental health by increasing stress and removing or reducing access to social support systems within the neighborhood they settled in postmigration, limiting the study due to the unique set of characteristics this sample faced.

Conclusion
The COVID-19 pandemic added to existing challenges relating to local migration, increasing risk factors for migrant’s mental health, removing protective factors they sought in migrating to Spain, and complicating their post-migration adaptation by influencing their legal paperwork applications, children's schooling, employment, housing, language acquisition, and cultural integration.
Preparation and Characterization of Adsorbents from Kluwak Shell (Pangium edule) Modified by Surfactant of HDTMA-Br
Authors: Ananda Zhafira Dwika , Dewi Ratna Sari 
Published: January 2025

This research aims to determine the characteristics of adsorbents made from kluwak shell activated carbon modified by HDTMA-Br surfactant. Providing adsorbents is carried out using the contacting method. The FTIR characterization results show the presence of the CH3 from N-( group possessed by the HDTMA-Br surfactant at wave number 1500 . SEM characterization shows that the morphology of HDTMA-Br surfactant modified active carbon appears to have a surface with some of the pores closed due to electrostatic interactions compared to unmodified active carbon which has open pores. The results showed that the functional groups and morphology of activated carbon changed after contact with HDTMA-Br surfactant which was related to the absorption capacity of activated carbon.
Pengaruh Kadar Air dan Ketebalan Papan Terhadap Laju Pengeringan Kayu Karet (Hevea brasiliensis) dengan Penerapan Fase Pendinginan
Authors: Wijayanto Arip 
Published: January 2025

ABSTRACT
Rubber wood is one of the wood species used as furniture raw material. Before processing it into furniture, it needs to be dried first until the moisture content meets the SNI requirements. In this study, drying data for rubber wood with different initial moisture content at several different thicknesses were taken from a furniture company in Central Java and then analyzed descriptively using Microsoft Excel. In the drying process, the company applies a cooling phase in between the heating phases. The results of the data analysis show that drying wood with a thickness of 30 mm takes longer than that with a thickness of 25 mm. On the other hand, in the same initial moisture content range, rubber wood with a thickness of 30 mm has a drying rate that is smaller than the drying rate for wood with a thickness of 25 mm. In the higher moisture content ranges the wood drying rate is greater than rubber wood with a low initial moisture content.

Keywords: cooling phase, drying, moisture content, rubber wood, thickness

ABSTRAK
Salah satu jenis kayu yang digunakan sebagai bahan baku furnitur adalah kayu karet. Sebelum diolah menjadi furnitur kayu karet perlu dikeringkan terlebih dahulu sampai kadar airnya memenuhi persyaratan SNI tentang kayu untuk furnitur. Penelitian ini data pengeringan kayu karet dengan kadar air awal berbeda pada beberapa jenis ketebalan berbeda diambil dari perusahaan furnitur di Jawa Tengah dan kemudian diolah secara deskriptif menggunakan microsoft excel. Proses pengeringan di perusahaan tersebut menerapkan fase pendinginan di sela-sela fase pemanasan. Hasil pengolahan data menunjukkan bahwa pengeringan kayu ketebalan 30 mm membutuhkan waktu yang lebih lama dibandingkan ketebalan 25 mm. Sebaliknya, pada rentang kadar air awal yang sama kayu karet dengan ketebalan 30 mm memiliki laju pengeringan yang lebih kecil dibandingkan laju pengeringan kayu ketebalan 25 mm. Rentang kadar air yang lebih tinggi laju pengeringan kayu lebih besar dibandingkan kayu karet dengan kadar air awal yang rendah.

Kata kunci: fase pendinginan,kadar air, kayu karet, ketebalan, pengeringan
In-Hospital Diabetes Management by a Diabetes Team and Insulin Titration Algorithms Based on Continuous Glucose Monitoring or Point-of-Care Glucose Testing in Patients With Type 2 Diabetes (DIATEC): A Randomized Controlled Trial
Authors: Olsen Mikkel T. , Klarskov Carina K. , Jensen Signe H. , Rasmussen Louise M. , Lindegaard Birgitte , Andersen Jonas A. , Gottlieb Hans , Lunding Suzanne , Pedersen-Bjergaard Ulrik , Hansen Katrine B. , Kristensen Peter L. 
Published: January 2025

OBJECTIVE
The DIATEC trial investigates the glycemic and clinical effects of inpatient continuous glucose monitoring (CGM)–guided insulin titration by diabetes teams.

RESEARCH DESIGN AND METHODS
This two-center trial randomized 166 non–intensive care unit patients with type 2 diabetes. Diabetes management was performed by regular staff, guided by diabetes teams using insulin titration algorithms based on either point-of-care glucose testing or CGM. The primary outcome was the difference in time in range (TIR) (3.9–10.0 mmol/L) between the two arms. Outcomes were assessed during hospitalization.

RESULTS
The CGM arm achieved a higher median (interquartile range [IQR]) TIR of 77.6% (24.4%) vs. 62.7% (31.5%) in the POC arm (P &lt; 0.001). Median (IQR) time above range (TAR) &gt;10.0 mmol/L was lower in the CGM arm at 21.1% (24.8%) vs. 36.5% (30.3%) in the POC arm (P = 0.001), and time below range (TBR) &lt;3.9 mmol/L was reduced by CGM, with a relative difference to POC of 0.57 (95% CI 0.34–0.97; P = 0.042). Prolonged hypoglycemic events decreased (incidence rate ratio [IRR] 0.13; 95% CI 0.04–0.46; P = 0.001), and the mean (SD) coefficient of variation was lower in the CGM arm at 25.4% (6.3%) vs. 28.0% (8.2%) in the POC arm (P = 0.024). Mean (SD) total insulin doses were reduced in the CGM arm at 24.1 (13.9) vs. 29.3 (13.9) IU/day in the POC arm (P = 0.049). A composite of complications was lower in the CGM arm (IRR 0.76; 95% CI 0.59–0.98; P = 0.032).

CONCLUSIONS
In-hospital CGM increased TIR by 15 percentage points, mainly by reducing TAR. CGM also lowered TBR, glycemic variability, prolonged hypoglycemic events, insulin usage, and in-hospital complications.
Optimizing Science Process Skills through Multiple Representation
Authors: Arrofa Acesta , Eli Hermawati  , Adila Nurfadilah  
Published: January 2025

This research is motivated by students' low science process skills in science subjects, which is caused by conventional teaching methods focusing on memorization, limited variations in learning models and minimal student involvement. This study aims to analyze the effect of the multiple representation learning model on improving science process skills in elementary school students. The method used in this research is the quantitative research method of experimental research type, using a nonquivalent control group design. The population used in this study were all fifth-grade elementary school students. The technique used in taking research samples is the Purposive Sampling technique. The sample in this study comprised students from the VA and VB classes, totalling 54. Data collection methods using test techniques and documentation. The instrument used in collecting data is a test question sheet. The data analysis technique used inferential statistical analysis. The results showed significant differences in science process skills between experimental and control classes and real disparities in improving skills that support the representation of multiple-representation learning models. So, the multiple representation learning model can improve science process skills in elementary school students. This research is expected to help improve the quality of science teaching and students' science skills in elementary schools.
PENGARUH INTELLECTUAL CAPITAL, GOOD CORPORATE GOVERNANCE, DAN FREE CASH FLOW TERHADAP NILAI PERUSAHAAN
Authors: Fitria Astri , Syahrenny Nenny 
Published: January 2025

Tujuan penelitian ini adalah untuk menguji pengaruh intellectual capital good corporate governance, dan free cash flow terhadap nilai perusahaan pada perusahaan perbankan yang terdaftar di Bursa Efek Indonesia (BEI) selama periode 2019-2021. Intellectual capital diproksikan dengan VAIC, good corporate governance diproksikan dengan kepemilikan manajerial dan kepemilikan institusional, free cash flow diproksikan dengan FCF, dan nilai perusahaan diproksikan dengan Tobin’s Q. Penelitian ini merupakan penelitian kuantitatif. Berdasarkan metode purposive sampling diperoleh 123 sampel dari 41 perusahaan perbankan yang terdaftar di Bursa Efek Indonesia periode 2019-2021. Teknik analisis data yang digunakan adalah regresi linear berganda. Hasil penelitian ini menunjukkan bahwa intellectual capital tidak berpengaruh terhadap nilai perusahaan, kepemilikan manajerial berpengaruh positif terhadap nilai perusahaan, kepemilikan institusional tidak berpengaruh terhadap nilai perusahaan, dan free cash flow berpengaruh positif terhadap nilai perusahaan
Vitamin E concentrations in hospitalized adult horses and foals
Authors: Palmisano Megan G. , Colmer Sarah F. , Saw Yih Ling , Xu Xin , Stefanovski Darko , Murphy Lisa , Johnson Amy L. 
Published: January 2025

Abstract

OBJECTIVE
To determine the prevalence of vitamin E deficiency in horses at admission and at the time of discharge. The hypothesis was that vitamin E concentrations would decrease during hospitalization.

METHODS
A prospective cohort study was performed of client-owned horses admitted as patients or companions through the emergency service at a tertiary referral center. Exclusion criteria included vitamin E supplementation. Whole blood was collected into an additive-free tube at the time of admission for all horses and at discharge if the horse was hospitalized for a minimum of 5 days. Serum vitamin E concentration was obtained with high-performance liquid chromatography. Data were analyzed with mixed-effects linear regression and the Spearman rank correlation for confounding factors.

RESULTS
A total of 12.7% of horses were deficient at admission, including 16.5% of adults and 5.5% of foals (< 3 months old). Of horses hospitalized for a minimum of 5 days, 6.7% were deficient at the time of discharge, including 0% of foals and 10% of adults. Duration of hospitalization had no significant effect on vitamin E concentration when all patients were considered.

CONCLUSIONS
Vitamin E deficiency is prevalent in horses. Horses admitted to the hospital do not require vitamin E supplementation to maintain adequate concentrations.

CLINICAL RELEVANCE
Approximately 1 in 6 horses presented to the emergency service were deficient in vitamin E. Vitamin E concentrations should be measured routinely in horses and supplemented if indicated by the presence of deficiency or the patient’s underlying disease pathophysiology.
Justice or Injustice: An Analysis of Selected Stories in Petina Gappah’s Rotten Row
Authors: Muganiwa Josephine 
Published: January 2025

Taking a purely literary analytic approach, this article explores use of the notion of justice in Petina Gappah’s collection of short stories entitled Rotten Row. Each story begins with a quotation from the Bible and reflects on the abortion of justice in the context of applied system; Roman-Dutch law, mob justice, karma or Ngozi (retributive spirit). The article explores the ironies represented in the stories with regard to the expectations of the execution of justice and what actually happens. Gappah seems to be calling on humanity to reflect on their actions in as much as they impact on other people no matter how insignificant they may seem. This serves to redefine the causes and effects of crime which in turn redefines victims, perpetrators and victors in various crime contexts.
An Informetric Perspective of Intellectual Property Research in Africa using the SCOPUS Database
Authors: Ngwenya Sibongile , Onyancha Omwoyo Bosire 
Published: January 2025

Intellectual property (IP) issues are addressed globally through multilateral instruments, such as the trade-related aspects of intellectual property rights (TRIPs). Such global settings may be inadequate to consider African regional issues. However, the discourse regarding IP in the African region seems to be limited. This study was conducted to examine documents on IP in Africa with the aim of determining the availability of publications and establishing the obstacles that hinder scholarly publishing on IP in Africa. This was a quantitative study conducted on SCOPUS on 14 August 2023, using the search term “intellectual property in Africa,” which retrieved a total of 2 316 documents (2000–2022). The results showed that, out of the 50 countries with documents on IP in Africa, only 11 were African countries, while six of the 10 institutes were universities in Africa. The publications were in 12 document types, and there were five dominant subject areas. Only three out of the 10 prominent authors were affiliated with institutions in Africa, and none of the top five journals belonged to an African country. Only one funding sponsor and one language were African. The researchers concluded that publications on IP in Africa were available in a variety of types, cutting across disciplines. However, they were very few and limited to certain years, countries and institutions due to issues of authorship, source, funding sponsor, and language of publication. There is a need to raise awareness of the need for scholarly discourse regarding IP in the African context.
Using the Mask R-CNN model for segmentation of real estate objects in aerial photographs
Authors: Vinokurov Igor Victorovich 
Published: January 2025

Массовое появление незаконных и незарегистрированных в Едином
Государственном Реестре Недвижимости (ЕГРН) объектов недвижимости
осложняет кадастровый учёт для многих субъектов территориального и
административного уровня. Традиционные методы выявления объектов
подобных типов, основанные на ручном анализе геопространственных данных,
трудоёмки и требуют значительного времени.
Для повышения эффективности этого процесса предлагается
автоматизировать обнаружение объектов на аэрофотоснимках путём решения
задачи инстанс-сегментации с использованием модели глубокого обучения
Mask R-CNN. В статье описана подготовка набора данных для этой модели,
исследованы основные метрики качества и проанализированы полученные
результаты. Показана эффективность модели Mask R-CNN при обнаружении
объектов недвижимости, не имеющих регистрации в ЕГРН.