bluuebunny/crossref_metadata_2025_split huggingface dataset:
Dissemination of Integron Class 1 among XDR isolates of P. aeruginosa in Najaf City
Authors: Al-Jelehawy Alaa Hamza Jaber , Nader Baker Ghassan , Salah Khadija Thaer 
Published: January 2024

Background: Integrons are gene capture systems observed in chromosomes, plasmids, and transposons, where identified and capture multiple gene cassettes. Integerons are consists of 3 elements: the initial is integrase gene (int1) encoding integrase enzyme (int1), which is essential to insertion or deletion of specific site. The second element is attI as integron-connected recombination site. The 3rd element is promoter (Pc), which is required in the expression of cassette-connected genes.
Aim of the Study: This thesis designed to examine the occurrence of integron class one genes among XDR isolates of P. aeruginosa.
Methods: An overall of 79 specimens were isolated from patients during the period of study and the specimens were carried to the laboratory. By monoplex PCR assay, the 19 XDR isolates of P. aeruginosa were investigated for the presence of integrons class one using intI1primer.
Results: This result found that 8 isolates are isolated from burns, 7 isolates are from urine, 4 isolates are from wounds. The PCR results show that 17 (89.5%) of the isolates harbored integrase (intI1) gene, while two isolate (10.5%) was negative for intI1 gene. Conclusions: Present result showed elevated occurrence of integrons class one among XDR isolates of P.aeruginosa.
Glucagon-Like Peptide-1 Receptor Agonists and Pancreatic Cancer Risk in Patients With Type 2 Diabetes
Authors: Dankner Rachel , Murad Havi , Agay Nirit , Olmer Liraz , Freedman Laurence S. 
Published: January 2024

ImportanceConcerns have been raised that glucagon-like peptide-1 receptor agonists (GLP-1RA) may increase the risk of pancreatic cancer.ObjectiveTo investigate the association of GLP-1RA treatment with pancreatic cancer incidence over 9 years of follow-up.Design, Setting, and ParticipantsIn this population-based historical cohort study, adult patients (aged 21 to 89 years) with type 2 diabetes insured by Clalit Healthcare Services, the largest state-mandated health organization in Israel, were followed up from 2009, when GLP-1RA became available in Israel, until pancreatic cancer diagnosis, death, reaching age 90 years, or end of follow-up (December 2017). Data were analyzed from June 2022 to November 2023.ExposuresTreatment with GLP-1RA was compared with basal insulin.Main Outcome and MeasuresPancreatic cancer incidence was compared according to weighted cumulative exposures to GLP-1RA and to basal insulin in a Cox model implemented in discrete time, with time origin at 2 years after diabetes diagnosis, adjusting for confounding. In sensitivity analyses, propensity score–matched pair new-user design and prevalent new-user design were used for the comparison. Because of risk for reverse-causation bias, results in the fifth to seventh year after medication were emphasized.ResultsDuring a cumulative follow-up of 3 290 439 person-years of 543 595 adults with a mean (SD) age of 59.9 (12.8) years (277 502 women [51%]) with incident diabetes, 1665 patients received pancreatic cancer diagnoses. In total, 33 377 patients (6.1%) used GLP-1RA and 106 849 (19.7%) used basal insulin. The estimated hazard ratio (HR) for pancreatic cancer associated with incremental use of 1 defined daily dose per day of GLP-1RA compared with basal insulin in the fifth to seventh year previously (all other characteristics, including age, sex, ethnic background, sociodemographic status, baseline body mass index, smoking history, history of pancreatitis, other glucose-lowering medications treatment history, and length of diabetes, being equal) was 0.50 (95% CI, 0.15-1.71). The new-user and prevalent new-user designs showed HRs from the fifth year onwards following initiation of GLP-1RA vs basal insulin of 0.52 (95 % CI, 0.19-1.41) and 0.75 (95 % CI, 0.37-1.53), respectively.Conclusions and RelevanceIn this historical cohort study of adults with type 2 diabetes, no support for an increased pancreatic cancer incidence over 7 years following start of GLP-1RA treatment was found. However, monitoring for pancreatic cancer risk beyond 7 years following initiation of therapy is still required.Trial RegistrationClinicalTrials.gov Identifier: NCT02072902
Consideration of needs and elements of residents' room signs in group homes for the elderly with dementia: Research on the systematic construction of an environment with non‐pharmacological therapy using signs Part 1
Authors: Mizuno Yusuke , Ito Shuko , Yamazaki Satoru , Katsumata Hideaki 
Published: January 2024

AbstractThis study provides an understanding of the needs for signs identifying rooms shown in group homes for the elderly with dementia (residents' room signs) and reveals the elements for planning. The purpose of staff displaying residents' room signs is to support residents with dementia returning to their own rooms by themselves. It is appropriate for the display contents shown on the residents' room signs to be displayed with the name of the resident approximately 30 to 50 mm. The appropriate display location is near the door handle at a height of approximately 1200 to 1400 mm.
Competitive Coordination of Ternary Anions Enabling Fast Li‐Ion Desolvation for Low‐Temperature Lithium Metal Batteries
Authors: Liang Ping , Hu Honglu , Dong Yang , Wang Zhaodong , Liu Kuiming , Ding Guoyu , Cheng Fangyi 
Published: January 2024

AbstractLithium metal batteries (LMBs) working at subzero temperatures are plagued by severe restrictions from the increased energy barrier of Li‐ion migration and desolvation. Herein, a competitive coordination strategy based on the ternary‐anion (TA) coupling of PF6−, TFSI−, and NO3− toward Li+ to achieve an anti‐freezing electrolyte with rapid kinetics is proposed. Computational and spectroscopic analyses reveal that the repulsive interaction among three anions and the preponderant coordination of the Li+‐NO3− further weaken the involvement degree of other anions in the Li+ solvation structure. As a result, the formulated TA electrolyte exhibits low binding energy of Li+‐anions (−4.62 eV), Li+ desolvation energy (17.04 kJ mol−1), and high ionic conductivity (3.39 mS cm−1 at −60 °C), simultaneously promoting anion‐derived solid electrolyte interphase on Li anode. Assembled Li||LiNi0.8Co0.1Mn0.1O2 cells employing the TA electrolyte exhibit robust capacity retention of 86.74% over 200 cycles at 25 °C and deliver a specific cathode capacity of 103.85 mAh g−1 at −60 °C. This study will enlighten the rational design of multi‐anion electrolytes to tailor the Li+ solvation/desolvation for advanced low‐temperature LMBs.
Advanced Hydrogel Material for Meniscus Repair
Authors: Li Chao , Deng Ronghui , Yang Meng , Yuan Fuzhen , Zhang Chong , Yu Jiakuo 
Published: January 2024

AbstractThe foundation of regenerative medicine is the investigation and progression of hypotheses and approaches for substituting, mending, reconstructing, or regenerating different tissues and organs within the human body. Nevertheless, due to the slender central segment and the entire unattached configuration of the meniscus, the efficacy of conventional therapies is unsatisfactory in reinstating meniscal health and functionality. To overcome these limitations, medical‐type hydrogels have the potential to provide a solution for meniscus repair and regeneration. Their biocompatibility and modifiability enable safe implantations in vivo, effectively modifying the pathophysiology of cells and the surrounding microenvironment at the site of meniscal injury. This article reviews the usage of different implantable medical‐type hydrogels in meniscal regeneration and repair. First, the structure and physiologic function of the meniscus are first briefly described. Following this, the use of varying hydrogels in meniscus repair is highlighted, alongside a discussion of different materials employed in constructing hydrogel implants. Lastly, an analysis of the issues and challenges associated with hydrogels in meniscus repair is presented.
Ion Concentration Polarization Tunes Interpore Interactions and Transport Properties of Nanopore Arrays
Authors: Cao Ethan , Cain DaVante , Silva Savannah , Siwy Zuzanna S. 
Published: January 2024

AbstractBiological processes require concerted function of many channels embedded in the cell membrane. While single solid‐state nanopores are already designed to mimic properties of individual biological channels, it is not yet known how to connect the pores to achieve biomimetic ionic circuits with interacting components. To identify fundamental processes that control interactions between nanopores embedded in the same membrane, a model system of minimal arrays consisting of two and three nanopores in silicon nitride films is designed. The constituent nanopores have an opening diameter <10 nm, and the interpore spacing is tuned between 15 and 200 nm. The experimental and modeling results reveal that nanopores in an array interact with each other via overlapping depletion zones created by the process of concentration polarization. The interactions can be further controlled by salt concentration and voltage. These results showcase a possibility of tuning interactions between nanopores and transport properties of arrays by chemical modification of the pore walls. Arrays consisting of nanoporous ionic diodes feature depletion zones with higher concentrations, and lower current suppression than homogeneously charged pores. These experiments and modeling provide the first steps to leave the constraints of single nanopores and to design biomimetic ionic circuits.
Topological Conversion of Nickel Foams to Monolithic Single‐Atom Catalysts
Authors: Zhang Hai , Tang Tongyu , Wang Hao‐Fan , Wang Hongjuan , Cao Yonghai , Yu Hao 
Published: January 2024

AbstractSingle‐atom catalysts have emerged as a promising class of catalysts due to their tailored coordination environments on the support, which can improve a variety of catalytic reactions, making them a highly desirable research subject in materials science with significant potential for industrial applications. However, traditional synthesis methods mainly obtain low‐yield powder catalysts without macroscopic mechanical strength, and also require tedious procedures, limiting their practicability. Here, monolithic carbon fibers are prepared with single atomic Ni sites directly from bulk metal. The synchronous support growth and metal diffusion realizes the effective atomization of nickel foam, and the innovative strategy of topological growth within a confined space results in robust and tough monolith. The application of this single‐atom‐monolith is demonstrated as a free‐standing electrode for highly efficient electrochemical CO2 reduction. The proposed synthesis strategy allows feasible preparation of functional single‐atom catalysts for potential industrial applications with advantages of using low‐cost raw materials, enabling large‐scale production, and providing processable, moldable monolithic materials.
Volatile Solid‐Assisted Molecular Assembly Enables Eco‐Friendly Processed Organic Photovoltaic Cells with High Efficiency and Photostability
Authors: Xu Lei , Xiong Yaomeng , Li Sunsun , Zhao Wenchao , Zhang Jianqi , Miao Chunyang , Zhang Yuyang , Zhang Tao , Wu Junjiang , Zhang Shaoqing , Peng Qiming , Wang Zhen , Ye Long , Hou Jianhui , Wang Jianpu 
Published: January 2024

AbstractAchieving environmentally friendly solvent‐processed high‐performance organic photovoltaic cells (OPVs) is a crucial step toward their commercialization. Currently, OPVs with competitive efficiencies rely heavily on harmful halogenated solvent additives. Herein, the green and low‐cost 9‐fluorenone (9‐FL) is employed as a solid additive. By using the o‐xylene/9‐FL solvent system, the PM6:BTP‐eC9‐based devices deliver power‐conversion efficiencies of 18.6% and 17.9% via spin‐coating and blade‐coating respectively, outperforming all PM6:Y‐series binary devices with green solvents. It is found that the addition of 9‐FL can regulate the molecular assembly of both PM6 and BTP‐eC9 in film‐formation (molecule‐level mixing) and post‐annealing (thermal‐assisted molecular reorganization with additive volatilization) stages, so as to optimize the blend morphology. As a result, the charge transport ability of donor and acceptor phases are simultaneously enhanced, and the trap‐assisted recombination is reduced, which contributes to the higher short‐circuit current density and fill factor. Moreover, the generation of photo‐induced traps is significantly suppressed, resulting in improved stability under illumination. It is further demonstrated the excellent universality of 9‐FL in various photoactive systems, making it a promising strategy to advance the development of eco‐friendly OPVs.
Synthetic Polymer Nanoparticles as an Abiotic Artificial Inhibitor of Tyrosinase
Authors: Zhang Tong , Li Yuan , Guo Jing , Sun Weiliang , Lv Yongqin 
Published: January 2024

AbstractAn innovative methodology is presented for synthesizing synthetic polymer nanoparticles (TINPs) as potent tyrosinase inhibitors. This inhibition strategy combines the integration of two distinct functionalities, phenol, and phenylboronic acid, within the TINPs structure. The phenyl group mimics the natural monophenol substrate, forming a strong coordination with the catalytic copper ion, significantly inhibiting tyrosinase activity. Additionally, phenylboronic acid interacts with catechol, another tyrosinase substrate, further reducing enzyme efficiency. The shared benzene ring in phenyl and phenylboronic acid enhances binding to tyrosinase's hydrophobic pocket near its copper active site, contributing to potent inhibition. TINPs exhibit exceptional performance, boasting an impressive IC50 value of 3.5×10−8 m and an inhibition constant of 9.8×10−9 m. Validation of the approach is unequivocally demonstrated through the successful inhibition of tyrosinase activity and melanin production, substantiated in both in vitro and in vivo scenarios. The mechanism of TINP inhibition is elucidated through circular dichroism and Fourier transform infrared spectroscopy. This study introduces a versatile design approach for developing abiotic polymer‐based enzyme inhibitors, expanding possibilities in enzyme inhibition research.
Ultrasensitive Optical Detection and Elimination of Residual Microtumors with a Postoperative Implantable Hydrogel Sensor for Preventing Cancer Recurrence
Authors: Geng Shizhen , Guo Pengke , Wang Jing , Zhang Yunya , Shi Yaru , Li Xinling , Cao Mengnian , Song Yutong , Zhang Hongling , Zhang Zhenzhong , Zhang Kaixiang , Song Haiwei , Shi Jinjin , Liu Junjie 
Published: January 2024

AbstractIn vivo optical imaging of trace biomarkers in residual microtumors holds significant promise for cancer prognosis but poses a formidable challenge. Here, a novel hydrogel sensor is designed for ultrasensitive and specific imaging of the elusive biomarker. This hydrogel sensor seamlessly integrates a molecular beacon nanoprobe with fibroblasts, offering both high tissue retention capability and an impressive signal‐to‐noise ratio for imaging. Signal amplification is accomplished through exonuclease I‐mediated biomarker recycling. The resulting hydrogel sensor sensitively detects the biomarker carcinoembryonic antigen with a detection limit of 1.8 pg mL−1 in test tubes. Moreover, it successfully identifies residual cancer nodules with a median diameter of less than 2 mm in mice bearing partially removed primary triple‐negative breast carcinomas (4T1). Notably, this hydrogel sensor is proven effective for the sensitive diagnosis of invasive tumors in post‐surgical mice with infiltrating 4T1 cells, leveraging the role of fibroblasts in locally enriching tumor cells. Furthermore, the residual microtumor is rapidly photothermal ablation by polydopamine‐based nanoprobe under the guidance of visualization, achieving ≈100% suppression of tumor recurrence and lung metastasis. This work offers a promising alternative strategy for visually detecting residual microtumors, potentially enhancing the prognosis of cancer patients following surgical interventions.
Validating Operating Stability and Biocompatibility Toward Safer Zinc‐Based Batteries
Authors: Liu Zhexuan , Chen Zhizhao , Lei Shaorong , Lu Bingan , Liang Shuquan , Li Jingjing , Zhou Jiang 
Published: January 2024

AbstractWearable and implantable electronics are standing at the frontiers of science and technology, driven by the increasing demands from modernized lifestyles. Zinc‐based batteries (ZBs) are regarded as ideal energy suppliers for these biocompatible electronics, but the corresponding biocompatibility validation is still in the initial stage. Meanwhile, complicated working conditions and some extreme electrolyte environments raise strict challenges, leaving less choices for safe ZBs. Toward higher operating stability and biocompatibility, this work proposes a hydrogel electrolyte featuring the moisture maintaining ability and a robust interface, which could further provide a milder environment for Zn‐MnO2 batteries and Zn‐air batteries. The cytotoxicity and tissue injury of batteries are evaluated with human cell lines and battery implantations on the animal models, which demonstrate the high biocompatibility of ZBs, while preliminary wearable devices implementation further verifies their operating stability. This work may provide a pathway for developing and validating biocompatible ZBs, contributing to their future practical employment in relevant fields.
Data‐Driven Tunnel Oxide Passivated Contact Solar Cell Performance Analysis Using Machine Learning
Authors: Zhou Jiakai , Jacobsson T. Jesper , Wang Zhi , Huang Qian , Zhang Xiaodan , Zhao Ying , Hou Guofu 
Published: January 2024

AbstractTunnel oxide passivated contacts (TOPCon) have gained interest as a way to increase the energy conversion efficiency of silicon solar cells, and the International Technology Roadmap of Photovoltaics forecasts TOPCon to become an important technology despite a few remaining challenges. To review the recent development of TOPCon cells, this work has compiled a dataset of all device data found in current literature, which sums up to 405 devices from 131 papers. This may seem like a surprisingly small number of cells given the recent interest in the TOPCon architecture, but it illustrates a problem of data dissemination in the field. Notwithstanding the limited number of cells, there is a great diversity in cell manufacturing procedures, and this work observes a gradual increase in performance indicating that the field has not yet converged on a set of best practices. By analyzing the data using statistical methods and machine learning (ML) algorithms, this work is able to reinforces some commonly held hypotheses related to the performance differences between different device architectures. This work also identifies a few more unintuitive feature combinations that would be of interest for further experimentally studies. This work also aims to inspire improvements in data management and dissemination within the TOPCon community.
Anode‐Free Sodium Metal Pouch Cell Using Cu3P Nanowires In Situ Grown on Current Collector
Authors: Zhang Wu , Zheng Jiale , Ren Ziang , Wang Juncheng , Luo Jianmin , Wang Yao , Tao Xinyong , Liu Tiefeng 
Published: January 2024

AbstractAnode‐free sodium metal battery (AFSMB) promises high energy density but suffers from the difficulty of maintaining high cycling stability. Nonuniform sodium (Na) deposition on the current collector is largely responsible for capacity decay in the cycling process of AFSMB. Here, a unique copper phosphide (Cu3P) nanowire is constructed on copper (Cu3P@Cu) as a sodium deposition substrate by an in situ growth method. Superior electrochemical performance of Cu3P@Cu anode is delivered in asymmetric cells with an average Coulombic efficiency of 99.8% for over 800 cycles at 1 mA cm−2 with 1 mA h cm−2. The symmetric cell of Cu3P@Cu displayed a cycling lifespan of over 2000 h at 2 mA cm−2 with 1 mA h cm−2. Cryo‐transmission electron microscope characterization and first principles calculation revealed that the low Na+ absorption energy and low Na+ diffusion energy barrier on Na3P promoted uniform Na nucleation and deposition, thus enhancing the Na surface stability. Moreover, anode‐free Na3V2(PO4)3//Cu3P@Cu full pouch cell delivered a considerable cycling capacity of ≈15 mA h in 170 cycles, demonstrating its practical feasibility.
High‐Throughput Strategies in the Discovery of Thermoelectric Materials
Authors: Deng Tingting , Qiu Pengfei , Yin Tingwei , Li Ze , Yang Jiong , Wei Tianran , Shi Xun 
Published: January 2024

AbstractSearching for new high‐performance thermoelectric (TE) materials that are economical and environmentally friendly is an urgent task for TE society, but the advancements are greatly limited by the time‐consuming and high cost of the traditional trial‐and‐error method. The significant progress achieved in the computing hardware, efficient computing methods, advance artificial intelligence algorithms, and rapidly growing material data have brought a paradigm shift in the investigation of TE materials. Many electrical and thermal performance descriptors are proposed and efficient high‐throughput (HTP) calculation methods are developed with the purpose to quickly screen new potential TE materials from the material databases. Some HTP experiment methods are also developed which can increase the density of information obtained in a single experiment with less time and lower cost. In addition, machine learning (ML) methods are also introduced in thermoelectrics. In this review, the HTP strategies in the discovery of TE materials are systematically summarized. The applications of performance descriptor, HTP calculation, HTP experiment, and ML in the discovery of new TE materials are reviewed. In addition, the challenges and possible directions in future research are also discussed.
Biomimetic Self‐Maturation Mineralization System for Enamel Repair
Authors: Lei Chen , Wang Kai‐yan , Ma Yu‐xuan , Hao Dong‐xiao , Zhu Yi‐na , Wan Qian‐qian , Zhang Jiang‐shan , Tay Franklin R , Mu Zhao , Niu Li‐na 
Published: January 2024

AbstractEnamel repair is crucial for restoring tooth function and halting dental caries. However, contemporary research often overlooks the retention of organic residues within the repair layer, which hinders the growth of dense crystals and compromises the properties of the repaired enamel. During the maturation of natural enamel, the organic matrix undergoes enzymatic processing to facilitate further crystal growth, resulting in a highly mineralized tissue. Inspired by this process, a biomimetic self‐maturation mineralization system is developed, comprising ribonucleic acid‐stabilized amorphous calcium phosphate (RNA‐ACP) and ribonuclease (RNase). The RNA‐ACP induces initial mineralization in the form of epitaxial crystal growth, while the RNase present in saliva automatically triggers a biomimetic self‐maturation process. The mechanistic study further indicates that RNA degradation prompts conformational rearrangement of the RNA‐ACP, effectively excluding the organic matter introduced earlier. This exclusion process promotes lateral crystal growth, resulting in the generation of denser enamel‐like apatite crystals that are devoid of organic residues. This strategy of eliminating organic residues from enamel crystals enhances the mechanical and physiochemical properties of the repaired enamel. The present study introduces a conceptual biomimetic mineralization strategy for effective enamel repair in clinical practice and offers potential insights into the mechanisms of biomineral formation.