bluuebunny/crossref_metadata_2025_split huggingface dataset:
Hydrogen sulfide detection and strong methane depletion in the super-stellar metallicity atmosphere of hot Jupiter HD 189733b
Authors: Fu Guangwei , Welbanks Luis , Deming Drake , Inglis Julie , Zhang Michael , Lothringer Joshua , Ih Jegug , Moses Julianne , Schlawin Everett , Knutson Heather , Henry Gregory , Greene Thomas , Sing David , Savel Arjun , Kempton Eliza , Louie Dana , Line Michael 
Published: October 2023

Abstract

Atmospheric characterization has been a powerful tool to understand the chemical and physical properties of close-in gas giant exoplanets. However, limited wavelength coverage and precision from previous observations have provided inconsistent and ambiguous results. Using the JWST Near Infrared Camera (NIRCam), we detected H2O (10 sigma), CO2 (26 sigma), CO (6 sigma), and H2S (7 sigma) in the transmission spectrum (2.4-5 micron) of the archetype hot Jupiter HD 189733b. With an equilibrium temperature of ~1200K, H2O, CO, and H2S are the main reservoirs for oxygen, carbon, and sulfur in a H2-dominated atmosphere. The corresponding inferred atmospheric metallicity is 3-5 times stellar. Methane is found to be depleted to below 0.01 ppm and provides strong evidence for a low carbon-to-oxygen ratio (<0.2), indicating a formation history of accreting water-rich icy planetesimals. The low C/O inference remains robust even considering the effects of photochemistry and vertical mixing. The detection of H2S, combined with the non-detection and strict upper limits for its photochemical product SO2, provide valuable constraints on atmospheric metallicity and photochemical processes that occur on highly irradiated hot Jupiters.
Electroacupuncture may promote the repair of spinal cord injury in rats by regulating the perineuronal net through Chst11
Authors: Chen Bowen , Hu Rong , Wu Xingying , Shi Mengting , Chen Yi , Zhang Jieqi , Ying Xihan , Huang Yi , Han Dexiong , Ma Ruijie 
Published: October 2023

Abstract
The aim of this study was to assess the expression of perineuronal net(PNN) and parvalbumin positive interneuron(PV+IN) in spinal cord injured rats and to characterize the effect of electroacupuncture(EA) on the modulation of PNN and PV+IN via Chst11. EA stimulation of jiaji acupoints (EX-B2) was started on day 1 after preparation of the spinal cord injury(SCI) model using the IH 0400 spinal cord impactor for 14 days. And chondroitinase ABC was used to treat spinal cord injured rats and compared with EA. A specially adapted adeno-associated virus (Chst11) was also injected into the T9 spinal cord of rats and combined with Basso-Beattie-Bresnahan scoring, in vivo fibre optic calcium imaging, western blotting and immunofluorescence. The results suggest that EA can effectively ameliorate the destruction of PNN structure and function after SCI, increase the activity of PV+IN, promote the regeneration of chondroitin sulfate and reverse the inhibitory effect of Chst11 on injury repair, maintain the balance of neuronal plasticity and stability, and promote spinal cord repair after injury.
Transcriptomic regulation of potato in response to drought stress
Authors: Kawamoto Kenta , Masutomi Hirofumi , Matsumoto Yuma , Ishihara Katsuyuki 
Published: October 2023

Abstract

Limited crop production due to lower rainfall has a major impact on the supply and demand of food for the human population. In potato (Solanum tuberosum L.), one of the major crops, there is also concern about a lack of production due to drought stress. Especially the cultivar "Toyoshiro" suitable for processing, has significant reduction in drought yield. Therefore, it is necessary to understand the mechanism of gene expression changes that occur in potato "Toyoshiro" plants and tubers during drought. Seed potatoes were split in half and one was used as a control plant that was watered daily, and the other was used as a drought-stressed plant that was watered off to mimic the weather conditions of the Tokachi-Obihiro region in 2021. These tubers were harvested at week 14 and the transcriptome was analyzed. The stressed plants showed 423 downregulated genes and 197 upregulated genes compared to the control. Factors related to phytosterol metabolism, cell wall modification, and heat stress response were detected among the genes whose expression changed. Moreover, the expression of "Abscisic acid and environmental stress-inducible protein TAS14 like (TAS14)," a molecule reported to be upregulated in several cultivars under drought stress, was also upregulated, and the localization of this molecule in the nucleus and plasma membrane was confirmed in an mCherry-tagged TAS14 mutant line. These results contribute to understanding the survival strategy system of potatoes in response to drought stress.
Development of an Antimicrobial Inorganic Polymer Based on Fly Ash and Metakaolin Incorporated by Nano-TiO 2 for Reactive Dye Removal
Authors: Ahmed Doaa A. , El-Apasery Morsy A. , Ragai Shereen M. 
Published: October 2023

Abstract
Advanced and eco-friendly construction materials are being developed to reduce pollution and improve wastewater treatment efficiency. One such material is a photocatalytic nanocomposite that uses industrial wastes and natural substances to eliminate pollution. A recent study explored using an inorganic polymer composite (FM) made from a mixture of 70% fly ash and 30% metakaolin, with sodium hydroxide and sodium silicate as an alkali activator. The study evaluated the mechanical and hydration characteristics of the FM composite after 28 days in 100% humidity at room temperature. The study also examined the effect of adding 2.5 wt.% of Nano-TiO2 to FM composite and how it affects its properties. Results indicate that adding Nano-TiO2 to FM composite enhances its mechanical, antibacterial, and photocatalytic capabilities. Specifically, FM-TiO2 composite showed 90% removal of reactive blue 19 dye effluent in sunlight after 90 minutes, making it an excellent choice for sustainable wastewater treatment. This study presents a cost-effective, eco-friendly solution to wastewater treatment, with added antimicrobial properties from Nano-TiO2.
Prospective evaluation of a modified apnea-test without disconnection from the ventilator in brain death candidates
Authors: Lambeck Johann , Bardutzky Jürgen , Strecker Christoph , Niesen Wolf-Dirk 
Published: October 2023

Abstract
Background:
The apnea test (AT) is the central clinical component in the diagnosis of brain death (BD) and normally entails disconnecting the patient from the ventilator followed by tracheal oxygen sufflation to ensure adequate oxygenation. Most international guidelines state that a lack of spontaneous breathing must be demonstrated when PaCO2 ≥ 60mmHg to rate the test as positive. However, the loss of positive end-expiratory pressure (PEEP) that is associated with disconnection from the ventilator may cause rapid desaturation, frequently leading to cardiopulmonary instability (especially in ARDS-patients) and generally putting patients at risk. This prospective study therefore aimed to investigate whether a modified version of the AT (mAT) in which the patient remained connected to the ventilator, is potentially less harmful yet remains a valid test.
Methods:
mAT was performed in all 140 BD candidates registered between January 2019 and December 2022: After 10 min of pre-oxygenation, (i) PEEP was increased by 2mbar, (ii) ventilation mode was switched to CPAP and (iii) apnea back-up mode was turned off (flow trigger 10l/min). mAT was considered positive when spontaneous breathing occurred upon increasing PaCO2 to ≥ 60 mmHg (baseline 35–45 mmHg). Clinical complications during/after mAT were documented.
Results
mAT was possible in 139/140 patients and had a median duration of 15 min (IQR 13–19). Severe complications did not occur. In n = 51 patients, the post-mAT PaO2 was lower than that during pre-mAT, while it was equal or higher in n = 88 cases. In ARDS-patients, apneic oxygenation during mAT improved PaO2. In n = 123 cases, there was a transient post-mAT drop in blood pressure, in n = 12 to a MAP < 60 mmHg.
Conclusions
The mAT is a safe and gentle means for identifying patients in whom the central respiratory drive has not failed.
A Formal Explanation Space for the Simultaneous Clustering of Neurology Phenotypes
Authors: Yelugam Raghu , Hier Daniel , Obafemi-Ajayi Tayo , Carrithers Michael , Wunsch Donald 
Published: October 2023

Abstract

Objective: Clustering is applied to biomedical datasets to identify meaningful subgroups of patients, proteins, genes, and diseases. Explainable AI (XAI) brings transparency and interpretability to the formation, composition, and quality of these clusters. This study creates a formal explanation space to enhance the interpretability of clusters of neurology phenotypes.
Methods: Subjects with dementia, movement disorders, and multiple sclerosis were clustered by neurological phenotype using spectral methods. To improve the interpretability of the clusters, we created an explanation space that described the data, explained the algorithm, evaluated cluster separation and quality, identified influential features, visualized cluster composition, and assessed biological plausibility.
Results: Text and equations were used to explain clustering algorithms. Cluster quality was evaluated with validity indices. The t-SNE plots illustrate cluster separation. Influential features were identified from SHAP plots. The cluster composition was visualized with heat maps and word clouds. Expert opinion assessed biological relevance. Spectral coclustering yielded clusters with higher validity indices and biological plausibility than spectral biclustering.
Conclusions: When biomedical data undergo simultaneous clustering, a formal explanation space can improve the transparency of the methods and interpretability of the results.
A Comparative Study of Reconstruction Modalities After Knee Joint-preserving Tumor Resection: Reconstruction with a Custom-made Endoprosthesis Versus Reconstruction with a Liquid Nitrogen-inactivated Autologous Bone Graft
Authors: Li Yuan , Xu Hairong , Shan Huachao , Ma Ke , Liu Weifeng , Niu Xiaohui 
Published: October 2023

Abstract
Background
This study evaluated the feasibility, complications, graft survival rate, and clinical outcomes of joint-preserving resection using a custom-made endoprosthesis and liquid nitrogen-inactivated autologous bone graft reconstruction in patients with malignant bone tumors around the knee joint.
Methods
We retrospectively analyzed 23 consecutive patients who underwent joint preservation surgery between 2008 and 2018 at our center. The study cohort included 13 patients who underwent custom-made endoprosthesis reconstruction and 10 who underwent liquid nitrogen-inactivated autologous bone graft reconstruction. The resected bone length, distance between the resection line and the joint, intraoperative blood loss, operation time, complications, and MSTS were compared between the two groups.
Results
The median follow-up time was 68.5 months in the endoprosthesis group and 65.3 months in the inactivated autograft group.. There were no significant differences in baseline characteristics, resected bone length, distance between the resection line and the joint, or intraoperative blood loss between the two groups. The operative time was longer in the inactivated bone graft group than in the endoprosthesis group (p < 0.001). The endoprosthesis group had more complications (six patients) and reoperations due to complications (five) than the inactivated autograft group (one), but there was no significant difference in the incidence of complications between the two groups (p = 0.158). The inactivated autograft group had one patient with type 1b complications, while the endoprosthesis group had one with type 1b complications, one with type 2b complications, and one with type 4a complications. One patient in the endoprosthesis group with type 5a complications experienced two soft tissue recurrences. The overall 5-year survival rate was 86.5% and the graft survival and final limb salvage rates were 100% in both groups. After the follow-up period, the mean MSTS scores were 91%±7% in the endoprosthesis group and 94%±6% in the inactivated autograft group, with no significant difference (p = 0.280).
Conclusion
Joint-preserving resection is a reliable and effective tumor resection method that can achieve good postoperative function. There were no significant differences in the incidence of complications, overall survival rate, or graft survival rate between the two groups.
Gangrene secondary to perineal invasion by rectal cancer：A case report and literature review
Authors: Li Xinyu , Shan Junqi , Ren Bingbing , Sun Yanlai 
Published: October 2023

Abstract
Background
Colorectal cancer(CRC) is currently the third most common cancer in the world. It usually metastasizes through lymphatic, blood, and intraperitoneal implantation. However, rectal cancer combined with perineal invasion after treated with chemotherapy is very rare.
Case presentation:
A 53-year-old male patient had a history of rectal cancer developed a recto-perineal fistula with redness, swelling and pain in the scrotum after repeated chemotherapy. After CT examination and investigative observation, the patient was diagnosed with a recto-perineal fistula. After surgical debridement and postoperative implant treatment, the patient's infection resolved, and the skin-grafting treatment worked well.
Study of heat and mass transfer and stress analysis in wet porous media during freeze- drying process
Authors: zhu Jiaao , Zhang Fujian , Guo Yun , Chen Na 
Published: October 2023

Abstract
As people's demand for food quality increases, freeze-dried food is favored due to its ability to maximize the retention of nutrients in food. However, the high cost of vacuum freeze-drying technology forces freeze-dried foods to be generally expensive. In order to improve the freeze-drying efficiency and reduce the cost of freeze-drying process, an in-depth analysis of the stress-strain and heat and mass transfer of materials in the freeze-drying process is quite necessary. In this paper, based on the knowledge of heat transfer, mass transfer and theoretical mechanics, the physical and mathematical model of potato in sublimation drying and desorption drying process was established. The heat and mass transfer, stress and strain of potato slices during sublimation drying and desorption drying were simulated and analyzed using COMSOL Multiphysics version 5.6 software. The results showed that the ratio of potato ice mass to initial ice mass decreased with the increase of drying time. Considering that the simulation ignored the actual situation that steam flowed out from around the potato slices, sublimation drying could actually remove more than 85% or even 90% of the water in the potato slices, and the drying effect was good. The amount of water bound to the potato decreases with drying time. The volume strain of potato in sublimation drying and desorption drying is very small, which is hard to be observed by naked eyes, and the freeze-drying effect is better.
Utility Maximization for The IRS-Assisted Wireless Powered Communication Network with Multiple Service Providers
Authors: Sun Xinge , Li Kangbai , Cui Miao , Zhang Guangchi 
Published: October 2023

Abstract

We consider a multi-device wireless-powered communication network, where an intelligent reflecting surface (IRS) is deployed to assist the wireless energy transfer (WET) from the power station (PS) to the information transmitter (IT) and the wireless information transfer (WIT) from the IT to the devices. The IRS, IT, and PS belong to different service providers, where the PS receives revenue from the IT for WET and pays fees to its energy source and the IRS, and the IT receives revenue from the devices for WIT and pays fees to the PS and the IRS. We model the interactions between the IT and the PS through a Stackelberg game and aim to achieve a win-win situation between them in terms of utility. Specifically, we solve a follower problem that maximizes the utility of the PS by jointly optimizing the IRS reflect beamforming and the transmit power of the PS, and a leader problem that maximizes the utility of the IT by jointly optimizing the energy price, the transmit power allocation of the IT, as well as the time allocation and the IRS reflect beamforming in the WET and WIT phases. To solve these problems, we propose efficient algorithms based on the alternating optimization, closed-form fractional programming, penalty-based equivalent transformation, and successive convex optimization techniques. Simulation results show that the proposed algorithm can significantly improve the PS and IT's utilities compared to the benchmark schemes.
Impact of various drying technologies on the drying characteristics, physicochemical properties, and antioxidant capacity of walnut green husk
Authors: Ao Jingfang , Wang Jun , Shen Heyu , Xie Yongkang , Cai Yingying , Xi Meihua , Hou Yujie , Li Mei , Luo Anwei 
Published: October 2023

Abstract
Walnut green husk (WGH) is common agricultural by-product with high yield and serious pollution. The present study aimed to evaluate the impacts of solar drying (SD), pulsed vacuum drying (PVD), short and medium infrared radiation drying (SMIR), hot air drying based on temperature and humidity control (TH-HAD), and heat pump drying (HPD) on the drying characteristics, energy consumption, physicochemical properties, bioactive compounds content and antioxidant capacity of WGH. Drying characteristics and drying kinetics showed that artificial drying can significantly improve drying efficiency. Compared with SD, the drying time of PVD, SMIR, TH-HAD, and HPD were reduced by 63.57%, 78.68%, 66.28%, and 53.97%, respectively. Specific energy consumption analysis demonstrated that HPD showed the lowest specific energy consumption, 2.15 kW·h/kg. Hydration properties analysis revealed PVD had the best water holding capacity and HPD sample had the best water solubility index (43.44%). Structural analysis showed the cell wall structure of WGH was damaged by different drying methods. Overall, Among the five drying methods, HPD has lower energy consumption, less time, and maintains good antioxidant activity. HPD has good potential in the commercial-scale production of WGH.
Energy characteristics and on-site prevention and control of coal rock burst failure induced by dynamic load disturbance in deep roadway
Authors: Guo Penghui , Yang Ke , Li Jiazhuo , Chi Xiaolou , Liu Wenjie , Wang Changcheng 
Published: October 2023

Abstract
The surrounding rock of deep roadway is in the state of limit stress equilibrium, under the environment of high vertical stress and strong tectonic stress, the dynamic load disturbance is prone to impact damage, which seriously hinders the safe and efficient production of the mine. Aiming at the problem of frequent rock burst in the main roadway of Gaojiapu Coal Mine, based on the analysis of the energy characteristics of microseismic monitoring of coal-rock burst failure in deep roadway, the evolution characteristics of different types of energy when coal-rock burst failure occurs in deep roadway under dynamic load disturbance are studied by means of theoretical analysis, numerical simulation and engineering practice, and the energy criterion of burst failure of surrounding rock in deep roadway is formed. The field microseismic monitoring results show that: when there is no impact danger in the roadway, the total energy of the microseismic day continues to remain at an energy level of less than 103 J, which is in a state of stable energy release; Weak impact danger, the total energy of microseismic day is 104 J; in the case of medium impact risk, the total energy of a microseismic day during one month is 105 J; strong impact danger, the total energy of two or more microseismic days is 105 J during a month, and the energy fluctuates greatly. The results of numerical simulation show that: at the initial stage of dynamic load disturbance, the plastic zone of roadway surrounding rock roof expands rapidly; in the middle and late stages of dynamic load disturbance, the plastic zone of roadway surrounding rock gradually develops to the floor, which will cause floor heave under the influence of bottom coal. The expansion of the plastic zone consumes the shape change energy stored in the coal and rock mass, if the dynamic failure occurs in the coal and rock mass, the volumetric strain energy stored in the coal and rock mass will be converted into kinetic energy, forming the roadway rock burst. Based on the results of numerical simulation and theoretical analysis, the optimum angle of large diameter drilling construction in a panel roadway is put forward.
Anaemia in hospitalized cancer patients: a retrospective study of two cohorts before and after the 2010 guideline update
Authors: Dû Katell Le , Septans Anne-Lise , Dômont Julien , Dupuis Olivier , Emmanuel Eric , Peribois Anne , Gaillard Sophie , Allix-Béguec Caroline 
Published: October 2023

Abstract
Purpose
The incidence of anemia and its consequences are often underestimated during cancer management. Recommendations were updated in 2010.
Methods
In this single-centre retrospective study, we assessed patient management before and after the publication of these recommendations. Eligible patients were treated for cancer and warranted overnight hospitalization over two periods (n = 206 in 2011, n = 143 in 2018). The diagnosis of anaemia was defined by a haemoglobin level below 12 and 13 g/dl for women and men, respectively.
Results
The prevalence of anaemia was 26% in 2011 and 16% in 2018 (p < .001). Biological assessment had changed between the two periods, with more tests of iron metabolism and measurements of inflammatory parameters. Patients hospitalized in 2018 had more advanced cancer and more severe anaemia. Rate of transfusion therapy did not change, but patients with mild and moderate anaemia were transfused less in 2018. Intravenous iron and erythropoietin-stimulating agent were used more frequently in 2018, mainly for mild anaemia and life-threatening anaemia, respectively. Overall survival was poor in both cohorts at 24 months after anaemia diagnosis (15.4% in 2011 and 6.5% in 2018, p = .048).
Conclusion
Practices have changed in the diagnosis of anaemia and prescriptions for erythropoietin-stimulating agents and intravenous iron have increased. Efforts must continue to explore the causes of anaemia, optimize the quality of life of anaemic patients and reduce transfusions.