bluuebunny/crossref_metadata_2025_split huggingface dataset:
Therapeutic factors of exclusive enteral nutrition-induced remission in adult patients with Crohn’s disease
Authors: Tu Jiancheng , Guo Kun , Fang Jian , Tao Lei , Huang Long 
Published: December 2023

Abstract

Objective:
The objective of this study was to explore the role of exclusive enteral nutrition (EEN) in inducing remission of Crohn’s disease (CD) during the active phase.

Methods:
A total of 86 patients who were admitted to many hospitals in Zhangjiagang City from January 2018 to December 2019 and were diagnosed with CD were enrolled in this study. According to the random number method, they were divided into the EEN group and the glucocorticoid group, with 43 patients in each group. Patients in the EEN group were treated with EEN support, and the glucocorticoid group was treated with hydrocortisone. Patients in the EEN group were treated with EEN support, and the glucocorticoid group was treated with hydrocortisone. Both were treated for 6 weeks and followed up every 7 days. Patients in the two groups were observed and compared, observe and analyze patients’ treatment compliance, hospitalization time, hospitalization costs, and quality of life after treatment. The improvement of CD activity index (CDAI) after treatment and clinical recurrence indicators of patients in the two groups were observed and compared, observe and analyze patients’ treatment compliance, hospitalization time, hospitalization costs, and quality of life after treatment indexes such as scores, adverse reactions, and complications.

Results:
The number of patients in the EEN group whose CDAI decreased ≥70 after 4 weeks of treatment was significantly higher than that in the glucocorticoid group, and the difference between the two groups was statistically significant (P < 0.05); the patients in the EEN group had CDAI >250 after treatment and enhanced glucocorticoid therapy. The incidence of other medical treatments and surgical treatments was lower than that of the glucocorticoid group. There was a statistically significant difference in the incidence of CDAI >250, glucocorticoids intensive treatment, and other drug treatments between the two groups (P < 0.05). Treatments between the two groups (P < 0.05); the comparison of secondary outcome indexes between the two groups after treatment showed that the scores of quality of life and treatment compliance in the EEN group were significantly higher than those in the glucocorticoid group, and the length of stay, incidence of adverse reactions, and complications in EEN group were significantly higher than those in the glucocorticoid group. The incidence of adverse reactions and complications in the EEN group was lower than those in the glucocorticoid group, with statistical significance between the two groups (P < 0.05–0.05).

Conclusion:
The EEN can significantly improve the nutritive index of patients with CD during the active phase, reduce the CDAI score, and significantly improve the patient’s quality of life score. The hospital stay is short, and the treatment effect is safe and effective. The hospital stay is short, and the treatment effect is safe and effective.
Efficacy of pantoprazole plus perforation repair for peptic ulcer and its effect on the stress response
Authors: Leng Zi-Yan , Wang Jia-Hao , Gao Lei , Shi Ke , Hua Hai-Bing 
Published: December 2023

BACKGROUND
Peptic ulcer (PU) is an abnormal phenomenon in which there is rupture of the mucosa of the digestive tract, which not only affects patients' normal life but also causes an economic burden due to its high medical costs.
AIM
To investigate the efficacy of pantoprazole (PPZ) plus perforation repair in patients with PU and its effect on the stress response.
METHODS
The study subjects were 108 PU patients admitted between July 2018 and July 2022, including 58 patients receiving PPZ plus perforation repair [research group (RG)] and 50 patients given simple perforation repair [control group (CG)]. The efficacy, somatostatin (SS) concentration, stress reaction [malondialdehyde (MDA), lipid peroxide (LPO)], inflammatory indices [tumor necrosis factor (TNF)-α, C-reactive protein (CRP), interleukin (IL)-1β], recurrence, and complications (perforation, hemorrhage, and pyloric obstruction) were compared.
RESULTS
The overall response rate was higher in the RG than in the CG. Patients in the RG had markedly elevated SS after treatment, which was higher than that of the CG, while MDA, LPO, TNF-, CRP, and IL-1β were significantly reduced to lower levels than those in the CG. Lower recurrence and complication rates were identified in the RG group.
CONCLUSION
Therefore, PPZ plus perforation repair is conducive to enhancing treatment outcomes in PU patients, reducing oxidative stress injury and excessive inflammatory reactions, and contributing to low recurrence and complication rates.
Percutaneous microwave ablation and transcatheter arterial chemoembolization for serum tumor markers and prognostics of middle-late primary hepatic carcinoma
Authors: Lin Zhi-Peng , Huang Da-Bei , Zou Xu-Gong , Chen Yuan , Li Xiao-Qun , Zhang Jian 
Published: December 2023

BACKGROUND
Primary hepatic carcinoma (PHC) has an insidious onset and is usually diagnosed in the middle and late stages. Although transcatheter arterial chemoembolization (TACE) is the preferred option for treating middle- and advanced-stage PHC, it has limited efficacy in killing tumor cells and poor long-term efficacy. TACE plus percutaneous microwave coagulation therapy (PMCT) is more effective than interventional therapy alone and can improve survival time. However, there are few reports on the effects of TACE and PMCT on serum marker levels and the prognosis of patients with advanced PHC.
AIM
To investigate the effect of PMCT + TACE on serum tumor markers and the prognosis of middle-late PHC.
METHODS
This retrospective study included 150 patients with middle-late PHC admitted to Zhongshan People’s Hospital between March 2018 and February 2021. Patients were divided into a single group (treated with TACE, n = 75) and a combined group (treated with TACE + PMCT, n = 75). Before and after treatment, the clinical efficacy and serum tumor marker levels [carbohydrate antigen 19-9 (CA19-9), alpha-fetoprotein (AFP), and carcinoembryonic antigen (CEA)] of both groups were observed. The 1-year survival rates and prognostic factors of the two groups were analyzed.
RESULTS
The combined group had 21 and 35 cases of complete remission (CR) and partial remission (PR), respectively. The single group had 13 and 25 cases of CR and PR, respectively. After 4 wk of treatment, the serum CA19-9, CEA, and AFP levels in the single and combined groups decreased, with the decrease in the combined group being more significant (P < 0.05). The 1-year survival rate of the combined group (80.00%) was higher than that of the single group (60.00%) (P < 0.05). The average survival time within 1 year in the combined group was 299.38 ± 61.13 d, longer than that in the single group (214.41 ± 72.97 d, P < 0.05). COX analysis revealed that tumor diameter, tumor number, and the treatment method were prognostic factors for patients with middle-late PHC (P < 0.05).
CONCLUSION
TACE + PMCT is effective in treating patients with mid-late PHC. It reduces the levels of tumor markers, prolongs survival, and improves prognosis.
Laparoscopic resection and endoscopic submucosal dissection for treating gastric ectopic pancreas
Authors: Zheng Hui-Da , Huang Qiao-Yi , Hu Yun-Huang , Ye Kai , Xu Jian-Hua 
Published: December 2023

BACKGROUND
Gastric ectopic pancreas (GEP) is a rare developmental abnormality that refers to the existence of pancreatic tissue in the stomach with no anatomical relationship with the main pancreas. It is usually difficult to diagnose through histological examination, and the choice of treatment method is crucial.
AIM
To describe the endoscopic ultrasound characteristics of GEP and evaluate the value of laparoscopic resection (LR) and endoscopic submucosal dissection (ESD).
METHODS
Forty-nine patients with GEP who underwent ESD and LR in the Second Affiliated Hospital of Fujian Medical University from May 2018 to July 2023 were retrospectively included. Data on clinical characteristics, endoscopic ultrasonography (EUS), ESD, and LR were collected and analyzed. The characteristics of EUS and the efficacy of the two treatments were analyzed.
RESULTS
The average age of the patients was 43.31 ± 13.50 years, and the average maximum diameter of the lesions was 1.55 ± 0.70 cm. The lesion originated from the mucosa in one patient (2.04%), from the submucosa in 42 patients (85.71%), and from the muscularis propria in 6 patients (12.25%). Twenty-nine patients (59.20%) with GEP showed umbilical depression on endoscopy. The most common initial symptom of GEP was abdominal pain (40.82%). Tumor markers, including carcinoembryonic antigen (CEA) and carbohydrate antigen 19-9 (CA-19-9), were generally within the normal range. One patient (2.04%) with GEP had increased CEA and CA-19-9 levels. However, no cancer tissue was found on postoperative pathological examination, and tumor markers returned to normal levels after resecting the lesion. There was no significant difference in surgery duration (72.42 ± 23.84 vs 74.17 ± 12.81 min) or hospital stay (3.70 ± 0.91 vs 3.83 ± 0.75 d) between the two methods. LR was more often used for patients with larger tumors and deeper origins. The amount of bleeding was significantly higher in LR than in ESD (11.28 ± 16.87 vs 16.67 ± 8.76 mL, P < 0.05). Surgery was associated with complete resection of the lesion without any serious complications; there were no cases of recurrence during the follow-up period.
CONCLUSION
GEP has unique characteristics in EUS. LR and ESD seem to be good choices for treating GEP. LR is better for large GEP with a deep origin. However, due to the rarity of GEP, multicenter large-scale studies are needed to describe its characteristics and evaluate the safety of LR and ESD.
Holistic conditions after colon cancer: A randomized controlled trial of systematic holistic care vs primary care
Authors: Wang Jing , Qiao Jian-Hong 
Published: December 2023

BACKGROUND
Study showed that systemic holistic care not only aids in disease treatment and physical recovery to a certain extent but also effectively enhances patient psychological well-being, social support, and overall quality of life (QoL).
AIM
To assess systematic holistic care impact on the recovery and well-being of postoperative patients with colon cancer.
METHODS
Our randomized controlled trial included 98 postoperative patients with colon cancer admitted to our hospital from June 2021 to June 2022. Patients were divided into control and study groups. The control group received conventional postoperative nursing care, whereas the study group received systematic holistic nursing care. We monitored gastrointestinal function recovery, and recorded changes in serum albumin (ALB), prealbumin (PA), psychological state, self-management, self-efficacy, QoL, and the occurrence of complications in patients before, at discharge, and 2 wk post-discharge. Spearman analysis assessed correlations between psychological state, self-management, self-efficacy, and QoL of patients in the study group 2 wk post-discharge.
RESULTS
Following the nursing intervention, we observed significantly shorter postoperative bowel sound recovery time, anal exhaust time, and defecation time in the study group than in the control group (P < 0.05). Patient ALB and PA levels, psychological status, self-management ability, self-efficacy and QoL at discharge and 2 wk post-discharge significantly improved, with greater improvements observed in the study group (P < 0.05). Both groups experienced complications post-interventions, but the intervention group had significantly lower complication rate (3/49, 6.12%) (P < 0.05). In the study group, patient anxiety, depression, self-management and QoL scores at 2 wk post-discharge exhibited a significant negative correlation (3/49, 6.12%) with QoL scores, with correlation coefficients of r = -0.273, -0.522, -0.344, and P < 0.01, respectively. Conversely, patient self-efficacy scores 2 wk post-discharge showed a positive correlation with QoL scores (r = 0.410, P = 0.000).
CONCLUSION
Systemic holistic nursing significantly benefits postoperative patients with colon cancer by promoting gastrointestinal recovery, improving post-operation well-being, reducing complications, and enhancing QoL.
Mutational separation and clinical outcomes of TP53 and CDH1 in gastric cancer
Authors: Liu He-Li , Peng Huan , Huang Chang-Hao , Zhou Hai-Yan , Ge Jie 
Published: December 2023

BACKGROUND
Gastric cancer (GC) is a deadly tumor with the fifth highest occurrence and highest global mortality rates. Owing to its heterogeneity, the underlying mechanism of GC remains unclear, and chemotherapy offers little benefit to individuals.
AIM
To investigate the clinical outcomes of TP53 and CDH1 mutations in GC.
METHODS
In this study, 202 gastric adenocarcinoma tumor tissues and their corresponding normal tissues were collected. A total of 490 genes were identified using target capture. Through t -test and Wilcoxon rank-sum test, somatic mutations, microsatellite instability, and clinical statistics, including overall survival, were detected, compared, and calculated.
RESULTS
The mutation rates of 32 genes, including TP53 , SPEN , FAT1 , and CDH1 exceeded 10%. TP53 mutations had a slightly lower overall occurrence rate (33%). The TP53 mutation rate was significantly higher in advanced stages (stage III/IV) than that in early stages (stage I/II) (P < 0.05). In contrast, CDH1 mutations were significantly associated with diffuse GC. TP53 is related to poor prognosis of advanced-stage tumors; nevertheless, CDH1 corresponds to a diffuse type of cancer. TP53 is exclusively mutated in CDH1 and is primarily affected by two distinct GC mechanisms.
CONCLUSION
Different somatic mutation patterns in TP53 and CDH1 indicate two major mechanisms of GC.
Significance of carcinoembryonic antigen detection in the early diagnosis of colorectal cancer: A systematic review and meta-analysis
Authors: Wang Rui , Wang Qin , Li Pan 
Published: December 2023

BACKGROUND
Colorectal cancer (CRC) is a prevalent malignant tumor involving adenomas that develop into malignant lesions. Carcinoembryonic antigen (CEA) is a non-specific serum biomarker upregulated in CRC. The concentration of CEA is modulated by tumor stage and grade, tumor site in the colon, ploidy status, and patient smoking status. This study aimed to evaluate current evidence regarding the diagnostic power of CEA levels in the early detection of CRC recurrence in adults.
AIM
To evaluate current evidence regarding the diagnostic power of CEA levels in the early detection of CRC recurrence in adults.
METHODS
A systematic search was performed using four databases: MEDLINE, Cochrane Trials, EMBASE, and the Web of Science. The inclusion criteria were as follows: Adult patients aged ≥ 18 years who had completed CRC curative treatment and were followed up postoperatively; reporting the number of CRC recurrences as an outcome; and randomized, clinical, cohort, and case-control study designs. Studies that were not published in English and animal studies were excluded. The following data were extracted by three independent reviewers: Study design, index tests, follow-up, patient characteristics, and primary outcomes. All statistical analyses were performed using the RevMan 5.4.1.
RESULTS
A total of 3232 studies were identified, with 73 remaining following the elimination of duplicates. After screening on predetermined criteria, 12 studies were included in the final analysis. At a reference standard of 5 mg/L, CEA detected only approximately half of recurrent CRCs, with a pooled sensitivity of 59% (range, 33%–83%) and sensitivity of 89% (range, 58%–97%).
CONCLUSION
CEA is a significant marker for CRC diagnosis. However, it has insufficient sensitivity and specificity to be used as a single biomarker of early CRC recurrence, with an essential proportion of false negatives.
Portal vein embolization for closure of marked arterioportal shunt of hepatocellular carcinoma to enable radioembolization: A case report
Authors: Wang Xiang-Dong , Ge Nai-Jian , Yang Ye-Fa 
Published: December 2023

BACKGROUND
Marked arterioportal shunt (APS) can be a contraindication for transarterial radioembolization (TARE) because of the risk of radiation-induced liver toxicity or pneumonitis. To date, the best method to close marked APS to reduce intrahepatic shunt (IHS) and hepatopulmonary shunt (HPS) before TARE has not been elucidated.
CASE SUMMARY
This case report describes a novel strategy of embolization of the portal venous outlet to reduce IHS and HPS caused by marked APS before TARE in a patient with advanced hepatocellular carcinoma (HCC). The patient had a significant intratumoral shunt from the tumor artery to the portal vein and had already been suspected based on pre-interventional magnetic resonance angiography, and digital subtraction angiography (DSA) confirmed the shunt. Selective right portal vein embolization (PVE) was performed to close the APS outlet and DSA confirmed complete closure. Technetium-99m macroaggregated albumin was administered and single photon emission computed tomography revealed a low HPS with 8.4%. Successful TARE was subsequently performed. No major procedure-related complication occurred.
CONCLUSION
Closure of APS with PVE during mapping angiography of advanced-stage HCC to enable reduction of HPS and subsequent TARE is feasible.
Awake robotic liver surgery: A case report
Authors: Delvecchio Antonella , Pavone Gaetano , Conticchio Maria , Piacente Claudia , Varvara Miriam , Ferraro Valentina , Stasi Matteo , Casella Annachiara , Filippo Rosalinda , Tedeschi Michele , Pullano Carmine , Inchingolo Riccardo , Delmonte Vito , Memeo Riccardo 
Published: December 2023

BACKGROUND
In recent years, minimally invasive liver resection has become a standard of care for liver tumors. Considering the need to treat increasingly fragile patients, general anesthesia is sometimes avoided due to respiratory complications. Therefore, surgical treatment with curative intent is abandoned in favor of a less invasive and less radical approach. Epidural anesthesia has been shown to reduce respiratory complications, especially in elderly patients with pre-existing lung disease.
CASE SUMMARY
A 77-year-old man with hepatitis-C-virus-related chronic liver disease underwent robotic liver resection for hepatocellular carcinoma. The patient was suffering from hypertension, diabetes and chronic obstructive pulmonary disease. The National Surgical Quality Improvement Program score for developing pneumonia was 9.2%. We planned a combined spinal–epidural anesthesia with conscious sedation to avoid general anesthesia. No modification of the standard surgical technique was necessary. Hemodynamics were stable and bleeding was minimal. The postoperative course was uneventful.
CONCLUSION
Robotic surgery in locoregional anesthesia with conscious sedation could be considered a safe and suitable approach in specialized centers and in selected patients.
Our First Supplement!
Authors: Ballestero Matheus , Pongeluppi Rodrigo Inácio , De Oliveira Ricardo Santos 
Published: December 2023

The Archives of Pediatric Neurosurgery Journal is proud to announce the release of its inaugural Supplement, marking a significant milestone more than three years since its establishment. The editorial team recognizes the continuous flow of scientific production, and the decision to introduce occasional supplements, prior to increasing the official journal numbers, underscores the steadfast and consistent publication policy of the APN.
In this supplement, we featured the abstracts from the "XIV Congress of the Brazilian Society for Pediatric Neurosurgery (SBNPed)" held in Goiânia, Brazil, from August 2 to 5, 2023, under the presidency of Dr. Paulo Ronaldo Jubé. Additionally, we also included videos of lectures conducted and endorsed by SBNPed and APN.
The Archives of Pediatric Neurosurgery Journal acknowledges the importance of research in Pediatric Neurosurgery and recognizes Brazil's leadership in various fields. We support the initiative to publish congress abstracts and encourage authors to submit their work as full articles for evaluation and potential publication.

Another key aspect is the promotion and encouragement by SBNPed and APN of symposia, making some lectures available for readers to benefit from, thereby fostering the dissemination of scientific knowledge. This supplement comprises three lectures from the 2020 Neuroendoscopy Symposium delivered by Dr. Ricardo Santos de Oliveira, Dr. Marcelo Volpon, and Roberto Alexandre Dezena.
We extend our gratitude to the entire editorial team, authors, and reviewers who contributed to the growth and development of the journal in 2023, and we look forward to an even more successful year in 2024!
Lojistik İşletmelerin Çalışan Profili İle Yenilik Odaklılığı Arasındaki İlişki
Authors: DİNDARİK Nazlıcan , FİDAN Yahya 
Published: December 2023

Amaç: Mevcut araştırmanın temel amacı; lojistik işletmelerde çalışanların profili ile yenilik odaklılığı arasındaki ilişkiyi incelemektir. Çalışmanın en temel ve öncelikli amacı lojistik işletme çalışanlarının yenilik odaklılıklarının demografik faktörlere göre farklılaşıp farklılaşmadığını tespit etmektir. Demografik faktörler göz önünde bulundurularak lojistik işletmelerde çalışanların pozisyonları, çalışma süreleri, eğitim durumları ve cinsiyetlerine ilişkin değerlendirmeler yapılmıştır. Demografik bilgiler ışığında yenilik odaklılıklarının çalışan profiline göre farklılaşıp farklılaşmadığı incelenmiştir.
Yöntem: Araştırma kapsamında nicel araştırmalar arasında yer alan veri toplama yöntemi olarak anket kullanılmıştır. Bu çalışmada Sabuncu (2014) ile Rejeb, vd. (2008) çalışmalarından yararlanılmıştır. Rejeb vd. (2008) çalışmasından alınan ifadeler uzmanlar tarafından dilimize çevrilerek uygulanmıştır.
Araştırmanın kapsamını İstanbul Ticaret Odası lojistik hizmetler komitesine kayıtlı işletmeler oluşturmaktadır. Anket soruları lojistik sektörünün farklı kademelerindeki çalışanlar tarafından yanıtlandırılmıştır. Alınan bilgilere göre verilerin toplanmasında araştırma yöntemlerinden biri olan yargısal örnekleme ya da diğer bir deyişle amaca yönelik örnekleme kullanılmıştır. Bu kapsamda internet üzerinden 201 katılımcıya ulaşılarak veriler toplanmıştır.
Bulgular: Araştırmada kullanılan yenilik odaklılık ölçeğinin güvenirlik ve geçerlik test sonuçlarının yüksek seviyede olduğu görülmüştür. Yapılan analizler sonucunda lojistik işletmelerde çalışan profilinin işletmedeki pozisyonu, çalışma süresi, eğitim düzeyi ve cinsiyeti ile yenilik odaklılığı arasında istatistiksel olarak anlamlılık bulunmamaktadır. Hipotezler reddedilmiştir.
Özgünlük: Çalışma kapsamında yapılan literatür taraması sonucunda işletmelerin çalışan profiline yönelik demografik faktörlerin ele alındığı birçok çalışma bulunmasına rağmen, işletmelerde demografik faktörler açısından çalışanların yenilik odaklılıklarında farklılık olup olmadığını inceleyen bir çalışmaya rastlanmamıştır. Bu bağlamda oluşturulan hipotezlerle lojistik işletmesi çalışanlarının yenilik odaklılıklarının demografik faktörlere göre farklılık göstermediği tespit edilmiş olup, diğer sektörlerde de yenilik odaklılıklarının durumunun belirlenmesine yönelik gelecek çalışmalara kapı açılmıştır.