bluuebunny/crossref_metadata_2025_split huggingface dataset:
The significance of goat milk in enhancing nutrition security: a scientiometric evaluation of research studies from 1966 to 2020
Authors: Idamokoro Emrobowansan Monday 
Published: November 2023

Abstract
Background
The present study aimed to reveal scientific findings on goat milk as an instrument to combat food and nutrition insecurity, while considering the recurrent challenge posed by food dearth and high rise of hunger among susceptible people of numerous nations.

Results
A sum of 9206 research outputs were extracted in a BibTeX design for evaluation by means of bibliometric package in R studio software. The generated result included, but not restricted to authors, citations, affiliations, journals and key words. Published research findings on goat milk as related to nutrition security retrieved from web of science (WOS) and Scopus data bases were used with an increase in scientific findings of an annual growth of 14.42% during the period of study. From the result of the study, Spain was rated in first position with a total of publications (n = 953), and a massive global scientific influence with the highest article citations (n = 17,035). The most commonly referred authors’ keywords in this research field were goat/s (n = 1605), milk (n = 920), dairy goat/s (n = 372), fatty acid/s (n = 307), cheese (n = 251), milk production (n = 220), milk consumption (n = 173), which all together gave a hint on associated research studies on goat milk and nutrition security.

Conclusions
The current study presented a global picture that covers the pool of scientific knowledge on goat milk research and its relevance in nutrition security, while giving a direction for more studies in this research area. It is of utmost importance to stress that the present findings only addressed prime areas of goat milk production as linked to nutrition security research, therefore, it is proposed that novel empirical study and potential research outcomes would give new understanding and insight on goat milk utilization as an avenue to tackle nutrition security issues as new findings emerges.
Root-associated symbiotic fungi enhance waterlogging tolerance of peach seedlings by increasing flavonoids and activities and gene expression of antioxidant enzymes
Authors: Liang Sheng-Min , Hashem Abeer , Abd-Allah Elsayed Fathi , Wu Qiang-Sheng 
Published: November 2023

AbstractRoot-associated symbiotic fungi can enhance the host plant’s ability to tolerate adverse environmental conditions, but it’s unclear whether and how they enhance waterlogged peach plants. This study aimed to investigate the effects of Funneliformis mosseae (Fm), an arbuscular mycorrhizal fungus, and Serendipita indica (Si), an endophytic fungus, on plant growth, root development, reactive oxygen species (ROS) levels, total flavonoids, ROS scavenging activity of flavonoids, and activities and gene expression of antioxidant enzymes in roots of waterlogged peach seedlings. Although waterlogging treatment had little effect on root development, Fm and Si, particularly Fm, improved root development variables to varying degrees. Waterlogging significantly promoted superoxide anion radicals (O2•−) and hydrogen peroxide (H2O2) levels, whereas Fm and Si distinctly reduced O2•− and H2O2 levels under waterlogging. Waterlogging triggered an increase in total flavonoids in fungi-inoculated seedlings, and the two fungi also significantly increased total flavonoid concentrations and the scavenging activity of total flavonoids to hydroxyl radical, O2•−, and 2,2-diphenyl-1-picrylhydrazyl radical. In addition, root fungal colonization rate was negatively and significantly correlated with O2•− and H2O2, but positively with total flavonoids. Under waterlogging conditions, Fm significantly raised root superoxide dismutase (SOD), catalase (CAT), and glutathione peroxidase (GPX) activities, and Si likewise elevated root SOD, CAT, GPX, and peroxidase (POD) activities, compared with uninoculated treatment. Although the expression of various antioxidant enzyme genes in roots remained mostly unchanged or were inhibited by the waterlogging, Fm up-regulated the expression of PpSOD3 and PpSOD7, whereas Si up-regulated the expression of PpSOD3, PpCAT1, PpGPX6, PpGPX8, and PpPOD1. In conclusion, low oxidative bursts in Fm- and Si-inoculated peach plants exposed to waterlogging were associated with an increase in total flavonoids as well as activities and gene expression of antioxidant enzymes.
Graphical Abstract
A deep learning model for predicting multidrug-resistant organism infection in critically ill patients
Authors: Wang Yaxi , Wang Gang , Zhao Yuxiao , Wang Cheng , Chen Chen , Ding Yaoyao , Lin Jing , You Jingjing , Gao Silong , Pang Xufeng 
Published: November 2023

Abstract
Background
This study aimed to apply the backpropagation neural network (BPNN) to develop a model for predicting multidrug-resistant organism (MDRO) infection in critically ill patients.

Methods
This study collected patient information admitted to the intensive care unit (ICU) of the Affiliated Hospital of Qingdao University from August 2021 to January 2022. All patients enrolled were divided randomly into a training set (80%) and a test set (20%). The least absolute shrinkage and selection operator and stepwise regression analysis were used to determine the independent risk factors for MDRO infection. A BPNN model was constructed based on these factors. Then, we externally validated this model in patients from May 2022 to July 2022 over the same center. The model performance was evaluated by the calibration curve, the area under the curve (AUC), sensitivity, specificity, and accuracy.

Results
In the primary cohort, 688 patients were enrolled, including 109 (15.84%) MDRO infection patients. Risk factors for MDRO infection, as determined by the primary cohort, included length of hospitalization, length of ICU stay, long-term bed rest, antibiotics use before ICU, acute physiology and chronic health evaluation II, invasive operation before ICU, quantity of antibiotics, chronic lung disease, and hypoproteinemia. There were 238 patients in the validation set, including 31 (13.03%) MDRO infection patients. This BPNN model yielded good calibration. The AUC of the training set, the test set and the validation set were 0.889 (95% CI 0.852–0.925), 0.919 (95% CI 0.856–0.983), and 0.811 (95% CI 0.731–0.891), respectively.

Conclusions
This study confirmed nine independent risk factors for MDRO infection. The BPNN model performed well and was potentially used to predict MDRO infection in ICU patients.
Anthropogenic nesting sites and density of Burrowing Parrot (Cyanoliseus patagonus) in northern Argentinian Patagonia
Authors: Lera Daiana N. , Cozzani Natalia , Tella José L. , Zalba Sergio 
Published: November 2023

Abstract
Background
The expansion of human activities and the development of urban centers are among the main driving forces accounting for the transformation and loss of natural environments. At the same time, and especially for some birds, anthropogenic activity provides new habitat resources. This is the case of the Burrowing Parrot (Cyanoliseus patagonus), in and around Bahía Blanca, a city of ca. 335,000 inhabitants in northern Argentinian Patagonia, where urban and rural quarries and constructed ravines on roadsides are where most of its reproductive activity occurs.

Methods
In this study we monitored anthropogenic nesting sites and estimated the number of breeding pairs from 2018 to 2023 through censuses conducted annually in 23 colonies within a radius of up to 20 km from the communal roost located in the city.

Results
Most of the nesting sites (57%), and the breeding pairs (60 to 80%) were in urban environments, and the remaining in rural areas. Ravines along roadsides and quarries represented the substrate that was most frequently used for nesting. Mean nest density was significantly higher in roadside ravines compared to quarries, and, in turn, higher in urban roadsides compared to rural roadsides.

Conclusion
Anthropogenic substrates appear as key components for the reproduction of the species, with possible effects on its numbers. The ability of the Burrowing Parrot to reproduce on artificial substrates in the urban environment, and especially the rapid colonization of recently opened sites, represents a new perspective for the conservation and management of its populations.
N-channel parity-time symmetry
Authors: Özgün Ege 
Published: November 2023

Abstract
We calculated the eigenvalues for a general N-channel coupled system with parity-time symmetry due to equal loss/gain. We found that the eigenspectrum displays a mixing of parity-time symmetric and broken phases, with N−2 of the eigenvalues being parity-time broken whereas the remaining two are either parity-time symmetric or broken depending on the loss/gain and coupling parameters. Our results also show that mixing of parity-time symmetric and parity-time broken phases can only be obtained for at least four channels if other degrees of freedom such as polarization or spin are not taken into account.
Two Cases of Frontal Variation of Idiopathic Calvarial Thinning—Therapeutic Effect of Denosumab and Romosozumab
Authors: Baek Seungjin , Hong Namki , Rhee Yumie 
Published: November 2023

Abstract
Idiopathic calvarial thinning is a rare condition that causes progressive, painless thinning of the skull bones without systemic disease. We present 2 cases of idiopathic calvarial thinning involving the bifrontal region. Both patients exhibited forehead depression and had normal biochemical tests except for mild vitamin D deficiency. The first patient received treatment with denosumab for 3 years, showing no further progression of the skull thinning. The second patient was treated with denosumab for 3 years, followed by romosozumab for 1 year, resulting in no further progression and even slight recovery of the skull thickness. These cases demonstrate that idiopathic calvarial thinning can involve the bifrontal region and highlight the favorable treatment and prognosis with denosumab or romosozumab.
Decaffeinated coffee and green tea extract inhibit foam cell atherosclerosis by lowering inflammation and improving cholesterol influx/efflux balance through upregulation of PPARγ and miR-155
Authors: Rachmawati Ermin , Rohman Mohammad Saifur , Sargowo Djanggan , Kalsum Umi , Lyrawati Diana , Lukitasari Mifetika 
Published: November 2023

Background Foam cells are markers of atherosclerosis and characterise advanced atherosclerotic plaque, stimulated by inflammation caused by high lipid levels in macrophages. The combination of decaffeinated coffee and green tea extract (DCGTE) has been suggested to have a role in foam cell inhibition. Objective We investigated the inhibiting role of DCGTE against foam cell formation, through modulation of the inflammation process and cholesterol metabolism in macrophage colony stimulating factor- (M-CSF) and oxidized low-density lipoprotein (oxLDL)-exposed macrophages. Methods Coffee and green tea were extracted by filtration and infusion respectively, and underwent decaffeination using active carbon and blanching methods, respectively. Cells were administered 160/160 and 320/320μg/ml of DCGTE. Foam cell formation was observed using a light microscope after staining with Oil Red O (ORO), and the accumulation of lipids in macrophages with ELISA. Observations of lipid influx and efflux were determined through semiquantitative cluster differentiation 36 (CD36) and ATP binding cassette transporter A1 (ABCA1) expression through immunofluorescence. The inflammation process was quantified using inflammatory/anti-inflammatory markers, e.g., tumor necrosis factor α (TNFα) and interleukin 10 (IL10) with ELISA. Peroxisome proliferator activated response γ (PPARγ) expression and activity were assessed with PCR and ELISA, respectively. The expression of microRNA 155 (miR-155) was examined using qPCR. Results DCGTE at the above concentrations tended to reduce foam cell numbers, significantly inhibited lipid accumulation (p=0.000), reduced CD36 expression (p=0.000) and TNFα secretion (p=0.000) in Raw264.7 exposed to M-CSF 50ng/ml and oxLDL 50μg/ml. PPARγ expression (p=0.00) and activity (p=0.001), miR-155 relative expression (p=0.000), and IL10 production (p=0.000) also increased. Conclusion DCGTE lowered foam cell numbers, possibly through attenuation of the inflammatory process and improvement of lipid/efflux mechanisms in M-CSF and oxLDL-stimulated Raw264.7 cells, via upregulation of PPARγ and miR-155. Our results suggest DCGTE may help prevent atherosclerosis-based diseases.
Influence of previous Zika virus infection on acute dengue episode
Authors: Estofolete Cassia F. , Versiani Alice F. , Dourado Fernanda S. , Milhim Bruno H. G. A. , Pacca Carolina C. , Silva Gislaine C. D. , Zini Nathalia , Santos Barbara F. dos , Gandolfi Flora A. , Mistrão Natalia F. B. , Garcia Pedro H. C. , Rocha Rodrigo S. , Gehrke Lee , Bosch Irene , Marques Rafael E. , Teixeira Mauro M. , da Fonseca Flavio G. , Vasilakis Nikos , Nogueira Maurício L. 
Published: November 2023

Background
The co-circulation of flaviviruses in tropical regions has led to the hypothesis that immunity generated by a previous dengue infection could promote severe disease outcomes in subsequent infections by heterologous serotypes. This study investigated the influence of antibodies generated by previous Zika infection on the clinical outcomes of dengue infection.

Methodology/Principal findings
We enrolled 1,043 laboratory confirmed dengue patients and investigated their prior infection to Zika or dengue. Severe forms of dengue disease were more frequent in patients with previous Zika infection, but not in those previously exposed to dengue.

Conclusions/Significance
Our findings suggest that previous Zika infection may represent a risk factor for subsequent severe dengue disease, but we did not find evidence of antibody-dependent enhancement (higher viral titer or pro-inflammatory cytokine overexpression) contributing to exacerbation of the subsequent dengue infection.
Metabolomic profiles associated with physical activity in White and African American adult men
Authors: Du Yan , Li Yuan-Yuan , Choi Byeong Yeob , Fernadez Roman , Su Kuan-Jui , Sharma Kumar , Qi Lu , Yin Zenong , Zhao Qi , Shen Hui , Qiu Chuan , Zhao Lan-Juan , Luo Zhe , Wu Li , Tian Qing , Deng Hong-Wen 
Published: November 2023

BackgroundPhysical activity (PA) is associated with various health benefits, especially in improving chronic health conditions. However, the metabolic changes in host metabolism in response to PA remain unclear, especially in racially/ethnically diverse populations.ObjectiveThis study is to assess the metabolic profiles associated with the frequency of PA in White and African American (AA) men.MethodsUsing the untargeted metabolomics data collected from 698 White and AA participants (mean age: 38.0±8.0, age range: 20–50) from the Louisiana Osteoporosis Study (LOS), we conducted linear regression models to examine metabolites that are associated with PA levels (assessed by self-reported regular exercise frequency levels: 0, 1–2, and ≥3 times per week) in White and AA men, respectively, as well as in the pooled sample. Covariates considered for statistical adjustments included race (only for the pooled sample), age, BMI, waist circumstance, smoking status, and alcohol drinking.ResultsOf the 1133 untargeted compounds, we identified 7 metabolites associated with PA levels in the pooled sample after covariate adjustment with a false discovery rate of 0.15. Specifically, compared to participants who did not exercise, those who exercised at a frequency ≥3 times/week showed higher abundances in uracil, orotate, 1-(1-enyl-palmitoyl)-2-oleoyl-GPE (P-16:0/18:1) (GPE), threonate, and glycerate, but lower abundances in salicyluric glucuronide and adenine in the pooled sample. However, in Whites, salicyluric glucuronide and orotate were not significant. Adenine, GPE, and threonate were not significant in AAs. In addition, the seven metabolites were not significantly different between participants who exercised ≥3 times/week and 1–2 times/week, nor significantly different between participants with 1–2 times/week and 0/week in the pooled sample and respective White and AA groups.ConclusionsMetabolite responses to PA are dose sensitive and may differ between White and AA populations. The identified metabolites may help advance our knowledge of guiding precision PA interventions. Studies with rigorous study designs are warranted to elucidate the relationship between PA and metabolites.
Comparison and interobserver reliability of three different methods for measuring the amount of the tibial tuberosity advancement in the preoperative planning of TTAT
Authors: Della Valle Giovanni , Aragosa Federica , Caterino Chiara , Piscitelli Alfonso , Di Palma Cristina , Lamagna Francesco , Fatone Gerardo 
Published: November 2023

IntroductionThe goal of preoperative planning techniques for advancement of the tibial tuberosity is to determine the amount of advancement required to achieve a postoperative patellar tendon angle of 90° and to select the optimal wedge size to achieve this target.Material and methodsThree radiographic methods for determining the advancement distance for the tibial tuberosity were evaluated for comparability and interobserver reliability. Among the methods developed, we decided to include the common tangent method, the tibial anatomy-based method, and the Bielecki method. For all techniques, radiographs were taken in mediolateral projection with the knee joint flexed at 135°. Three observers with different levels of experience independently evaluated and scored the degree of osteoarthritis for each stifle, as previously described, and performed measurements of the amount of advancement of the tibial tuberosity on 33 stifles using common tangent method, tibial anatomy-based method, and Bielecki method.ResultsAccording to the results, the overall score for osteoarthritis in the mediolateral view was influenced by the experience of the observers, which contradicts the results from a previous study. Regarding the measurement methods used to assess advancement, poor interobserver reliability was found for common tangent method and Bielecki method, while only a slightly moderate interobserver agreement was found for tibial anatomy-based method.DiscussionThese results are inconsistent with data collected by Bielecki and colleagues. Moreover, measurements from common tangent method and tibial anatomy-based method were overlapping, as confirmed previously. Conversely, Bielecki method showed no agreement with the other methods included in the present study, with a significantly higher mean rank, probably due to its correction formula. Based on the results of the present study, tibial anatomy-based method has better interobserver reliability and is easier to perform according to the observers.
Dietary patterns among adults in three low-income urban communities in Accra, Ghana
Authors: Kushitor Sandra Boatemaa , Alangea Deda Ogum , Aryeetey Richmond , de-Graft Aikins Ama 
Published: November 2023

Objective
Dietary patterns describe the dietary behaviour and habits of individuals. Unhealthy dietary patterns provide individuals with limited nutrients while increasing the risk of nutrition-related diseases. Unhealthy dietary patterns are high in urban areas, especially among low-income urban residents. This study examined dietary patterns in three low-income urban communities in Accra, Ghana, between 2011 and 2013.

Methods
This study used Wave 2 and 3 data from the Urban Health and Poverty Survey (EDULINK 2011 and 2013). The sample size was 960 in 2011 and 782 in 2013. Dietary pattern was examined using factor analysis and the NOVA food classification system. Summary statistics were computed for sociodemographic characteristics and diet frequency and pattern. Differences in dietary behaviours between 2011 and 2013 were also estimated. Three logistic regression models were computed to determine the predictors of dietary patterns.

Results
The frequency of consumption of animal-source foods (ASF) and fruits was higher in 2013 compared with 2011. The intake of processed culinary ingredients (NOVA Group 2), processed foods (NOVA Group 3) and ultra-processed foods (NOVA Group 4) was higher in 2013 versus 2011. In 2013, 29% consumed ultra-processed foods compared to 21% in 2011. Three dietary patterns (rice-based, snack-based, and staple and stew/soup) were identified. About two out of every five participants consumed the food items in the rice (43%) and staple and sauce patterns (40%). The proportion of participants who consumed the food items in the snack pattern was 35% in 2011 but 41% in 2013. Respondents aged 25–34 and those with higher education often consumed the snack-based and rice-based dietary patterns. In 2013, participants in Ussher Town had a higher probability of consuming food items in the snack pattern than those living in Agbogbloshie.

Conclusions
This study found that between 2011 and 2013, more participants consumed ASFs, fruits, and processed foods. A complex interplay of personal and socio-cultural factors influenced dietary intake. The findings of this study mirror global changes in diet and food systems, with important implications for the primary and secondary prevention of NCDs. Health promotion programs at the community level are needed to address the increasing levels of processed food consumption.