bluuebunny/crossref_metadata_2025_split huggingface dataset:
Inkarnationsdeutung bei Johannes von Damaskus in Auseinandersetzung mit der „koranischen“ Bewegung
Authors: Kiel Nikolai 
Published: November 2023

Abstract
John of Damascus (ca. 650/660 – 754 AD) is one of the first contemporary witnesses to critically examine the emergence of Islam and its holy scripture, the Qur’an. John came from a distinguished Melkite family that held political offices in state finance for generations. Like his father, he was initially a civil servant under the Arab rule of Caliph ‘Abd al-Malik (685 – 705). The anti-Christian movement that began in that time forced him to withdraw from public life and enter the Mar Saba monastery near Jerusalem. While at the monastery, John grappled with the text of the “new” religion and defended the Christian position. In this milieu, the interpretation of the divine incarnation occupied a central position. By demonstrating the divine incarnation in Jesus Christ, John makes convergences with the Qur’anic movement of the new rulers. In doing so, he highlights the Qur’ans high esteem of the Virgin Mary as well as the birth and humanity of her Son, Jesus Christ. In this way, he seeks to bring Christianity into agreement with the Qur’an and to break down theological barriers.
Oikoi stratiōtikoi. Open Questions on Land and Military Service in Byzantium (c. 7th–10th centuries)
Authors: Cosentino Salvatore 
Published: November 2023

Abstract
The expression oikoi stratiōtikoi, used in Constantine VII Porphyrogenitus as opposed to oikoi politikoi, designates all those families who were bound to military service. They, in the tenth century, were listed in various enlistment registers that were periodically updated, among which one was kept in Constantinople. There is solid evidence to argue that such an administrative practice originated in the eighth century, coinciding with a significant transformation in the enrolment of soldiers and their maintenance. A conscription procedure was devised in the age of the Isaurians, which, although it is not known whether it was on a voluntary or compulsory basis, entailed the entry in the military records (in Constantinople and the provinces) of every person in charge (oikodespotēs) of the family that had assumed the military burden. This implied in later periods a strong uncertainty in the relationship between service and its performance because registration rested on an ambiguous vocabulary. The ambiguity, in fact, was rooted in the polysemy of the concept of oikos, family unit, home and patrimony at the same time. While such a notion allowed the recruitment in thematic armies to function flexibly through the wide network of the family’s cognate and agnatic structure, precisely because the oikos was also a set of economic interests, it exposed the landed patrimony of military families to splitting and erosion. This ambiguity ended with Constantine VII’s famous law of 949, which regulated the property regime of the stratiōtikoi oikoi, a regime that, as the same provision explicitly states in several points, already existed previously throughout the empire. The law provided a precise economic quantification of the assets needed for each ‘military family’ to perform the service. Historiography has generally interpreted Constantine VII’s measure as an act breaking with the previous tradition, since military service appears in it much more markedly connoted as a patrimonial burden, rather than as a personal one. However, this ‘oppositional’ interpretation does not seem adequate for understanding the concept of oikos stratiōtikos, which from the outset must have implied a profound interrelationship between the personality of the service and its patrimonial basis, since the one did not exist without the other.
Reaching beneath the tip of the iceberg: A guide to the Freiburg Multimodal Interaction Corpus
Authors: Rühlemann Christoph , Ptak Alexander 
Published: November 2023

AbstractMost corpora tacitly subscribe to a speech-only view filtering out anything that is not a ‘word’ and transcribing the spoken language merely orthographically despite the fact that the “speech-only view on language is fundamentally incomplete” (Kok 2017, 2) due to the deep intertwining of the verbal, vocal, and kinesic modalities (Levinson and Holler 2014). This article introduces the Freiburg Multimodal Interaction Corpus (FreMIC), a multimodal and interactional corpus of unscripted conversation in English currently under construction. At the time of writing, FreMIC comprises (i) c. 29 h of video-recordings transcribed and annotated in detail and (ii) automatically (and manually) generated multimodal data. All conversations are transcribed in ELAN both orthographically and using Jeffersonian conventions to render verbal content and interactionally relevant details of sequencing (e.g. overlap, latching), temporal aspects (pauses, acceleration/deceleration), phonological aspects (e.g. intensity, pitch, stretching, truncation, voice quality), and laughter. Moreover, the orthographic transcriptions are exhaustively PoS-tagged using the CLAWS web tagger (Garside and Smith 1997). ELAN-based transcriptions also provide exhaustive annotations of re-enactments (also referred to as (free) direct speech, constructed dialogue, etc.) as well as silent gestures (meaningful gestures that occur without accompanying speech). The multimodal data are derived from psychophysiological measurements and eye tracking. The psychophysiological measurements include, inter alia, electrodermal activity or GSR, which is indicative of emotional arousal (e.g. Peräkylä et al. 2015). Eye tracking produces data of two kinds: gaze direction and pupil size. In FreMIC, gazes are automatically recorded using the area-of-interest technology. Gaze direction is interactionally key, for example, in turn-taking (e.g. Auer 2021) and re-enactments (e.g. Pfeiffer and Weiss 2022), while changes in pupil size provide a window onto cognitive intensity (e.g. Barthel and Sauppe 2019). To demonstrate what opportunities FreMIC’s (combination of) transcriptions, annotations, and multimodal data open up for research in Interactional (Corpus) Linguistics, this article reports on interim results derived from work-in-progress.
Modular Splicing Is Linked to Evolution in the Synapse-Specificity Molecule Kirrel3
Authors: Traenkner Dimitri , Shennib Omar , Johnson Alyssa , Weinbrom Adam , Taylor Matthew R. , Williams Megan E. 
Published: November 2023

AbstractKirrel3 is a cell-adhesion molecule that instructs the formation of specific synapses during brain development in mouse and Kirrel3 variants may be risk factors for autism and intellectual disabilities in humans. Kirrel3 is predicted to undergo alternative splicing but brain isoforms have not been studied. Here, we present the first in-depth characterization of Kirrel3 isoform diversity in brain using targeted, long-read mRNA sequencing of mouse hippocampus. We identified 19 isoforms with predicted transmembrane and secreted forms and show that even rare isoforms generate detectable protein in the brain. We also analyzed publicly-available long-read mRNA databases from human brain tissue and found 11 Kirrel3 isoforms that, similar to mouse, encode transmembrane and secreted forms. In mice and humans, Kirrel3 diversity arises from alternative, independent use of protein-domain coding exons and alternative early translation-stop signals. Intriguingly, the alternatively spliced exons appear at branch points in the chordate phylogenetic tree, including one exon only found in humans and their closest living relatives, the great apes. Together, these results validate a simple pipeline for analyzing isoform diversity in genes with low expression and suggest that Kirrel3 function is fine-tuned by alternative splicing and may play a role in brain evolution.
The “Cinematic Promise” of Video Game Music
Authors: Mc Glynn James Denis 
Published: November 2023

Consonant with recent developments that have contributed to the ongoing convergence of film and video game forms, a common aspiration exists among many contemporary “Triple A” titles to fulfil what we might call the “cinematic promise” of video games. Many recent releases illustrate that a shift has taken place towards certain games’ stylistic harnessing and hybridisation of cinematic idioms that, in turn, transforms the experience being marketed to gamers. One title in which these dual-aspirations are especially conspicuous is Final Fantasy VII Remake (Square Enix, 2020), a game that straddles an intricate balance between channelling elements of both the cinematic and the game’s original identity as a fifth-generation video game.
This article explores the ongoing convergence of scoring idioms for films and games. Remake is adopted as a central case study, considering the extent to which game and film music idioms coalesce as part of the game’s idiosyncratic musical identity and are foregrounded as a result of their interaction. I argue that the tension between Remake’s clear efforts to channel aspects of the cinematic alongside sounds, timbres, and compositional structures from the original game affords us new insights into: the relationship between film and game music; remakes and adaptations more generally; and game soundtracks that adapt pre-existing music. Beginning with overviews of existing research on (i) film and game music, and (ii) music in remakes, the article culminates in musical analyses of both Final Fantasy VII and its Remake, illustrating the palpable tension that emerges between Remake’s concessions to both film and game scoring conventions: arguably the defining characteristic of the game’s musical identity.
Cumulative Health Vulnerabilities Among Adolescents by Age and Neighborhood Opportunity
Authors: DiFiore Gabrielle , Wood Sarah , Jenssen Brian P. , Fiks Alexander G. , Mayne Stephanie L. 
Published: November 2023

BACKGROUND AND OBJECTIVES
Early detection of health vulnerabilities in adolescents is integral to promoting healthy behaviors into adulthood. Our objective was to quantify the prevalence of health vulnerabilities among adolescents and examine differences by age and neighborhood opportunity.

METHODS
In a cross-sectional analysis of electronic health record data for adolescents aged 13 to 18 years with preventive visits in a large pediatric primary care network between September 2021 and September 2022, we examined 5 health vulnerabilities: Tobacco use, substance use, firearm access, condomless intercourse, and depressive symptoms. Health vulnerabilities were assessed via self-reported adolescent health questionnaire and the validated Patient Health Questionnaire-Modified. Prevalence of health vulnerabilities were calculated alone and in combination, and compared by age and by quintile of neighborhood Child Opportunity Index (COI) score. Multivariable logistic regression estimated associations of neighborhood COI with reporting ≥2 health vulnerabilities.

RESULTS
Among 40 197 adolescents (57.7% aged 13–15 years, 66.3% living in “high”/”very high” COI neighborhoods), 29.7% reported at least 1 health vulnerability and 7.9% reported ≥2 vulnerabilities. Cumulative health vulnerabilities were more prevalent among older adolescents and adolescents from lower opportunity neighborhoods. In adjusted models, lower COI was associated with 65% higher odds of having ≥2 vulnerabilities (odds ratio 1.65, 95% confidence interval 1.43–1.91) compared with adolescents from the highest COI quintile.

CONCLUSIONS
Understanding the relationship between health vulnerabilities and neighborhood opportunities among adolescents may allow pediatric primary care providers and health systems to offer more tailored community support services and transdiagnostic specialized care navigation to address the health needs of teens with multiple vulnerabilities.
Geometric features and traffic dynamic analysis on 4-leg intersections
Authors: Saeed Wajahat , Saleh Muhammad Sohail , Gull Muhammad Naqash , Raza Hassan , Saeed Rafaqat , Shehzadi Tahira 
Published: November 2023

AbstractWith the escalating density of vehicles converging at road intersections, the surge in road accidents, traffic conflicts, and traffic congestion has emerged as a pressing concern. This research paper addresses these challenges by employing MC (manual control) techniques to mitigate encroachment issues at three selected intersections. These intersections were identified through a comprehensive analysis of the Ranking-based Instance Selection (RIS), enabling the design of suitable measures to facilitate smooth traffic flow and minimize the occurrence of crashes. In order to gather pertinent data, the study incorporates various parameters such as traffic volume, peak flow rate (PFR), traffic conflicts, accidents, and intersection inventory. Through the implementation of our proposed approaches, which involve both MC techniques and signalized operation, a supreme level of service (LOS) is attainable. Notably, our findings demonstrate a remarkable reduction in the volume-to-capacity ratio (v/c ratio) of up to 0.62. This paper thus serves as a significant contribution to the field of traffic management, offering practical insights for optimizing intersection design and effectively addressing the challenges posed by increased traffic density.
Circulating apelin, IL22RA2 and VEGF in pre-capillary pulmonary hypertension
Authors: Csósza Györgyi , Szűcs Gergő , Rozgonyi Zsolt , Csoma Balázs , Losonczy György , Müller Veronika , Karlócai Kristóf , Lázár Zsófia 
Published: November 2023

AbstractCytokines can modulate vascular remodelling and the adaptation of the right ventricle in pre-capillary pulmonary hypertension (PH). However, detailed data on the circulating levels of cytokines in patients are limited. We measured blood cytokine concentration in 39 treatment-naïve patients (pulmonary arterial hypertension: N = 16, chronic thromboembolic PH: N = 15, PH due to lung disease: N = 8) and 12 control subjects using enzyme-linked immunoassays. Apelin concentration >1,261 ng/mL identified patients with PH (66% sensitivity and 82% specificity), and in patients it was related to systolic pulmonary arterial pressure (PAP) (r = 0.33, P = 0.04), right atrial pressure (r = 0.38, P = 0.02), cardiac index (r = −0.34, P = 0.04), and right ventricular stroke work index (r = −0.47, P = 0.003). IL22RA2 concentration correlated with mean PAP (r = −0.32, P = 0.04) and serum N-terminal pro B-type natriuretic peptide level (r = −0.42, P = 0.01). VEGF concentration increased in patients upon clinical improvement (N = 16, P = 0.02). Circulating apelin is a novel biomarker of pre-capillary PH. Apelin and IL22RA2 levels are related to right ventricular function upon diagnosis of PH.
Verbesina molinaria (Asteraceae, Heliantheae) no es lo mismo que Verbesina oncophora
Authors: Soriano-Pantaleón Lizbeth , Cerros-Tlatilpa Rosa , Villaseñor José Luis 
Published: November 2023

Antecedentes: Verbesina molinaria B.L. Rob. & Greenm. y V. oncophora B.L. Rob. & Seaton son especies con circunscripción conflictiva; algunos autores las consideran como especies distintas mientras que otros como una sola (V. oncophora).
Preguntas: ¿Son dos especies de Verbesina? ¿Un análisis linear discriminante (LDA) ayudará a diferenciarlas?
Especies de estudio/Modelo matemático: Verbesina molinaria y V. oncophora / Pruebas de Royston, Shapiro-Wilk, Levene, correlación (Pearson), factor de inflación de la varianza (VIF) y LDA.
Sitio y años de estudio: México; 2022-2023.
Métodos: Se revisaron tipos, protólogos, así como ejemplares de ambas especies depositados en ENCB, HUMO, MEXU y UAMIZ, asignándoles un nombre preliminar y elaborando una matriz de datos. Se generaron diagramas de cajas para evaluar diferencias entre los caracteres analizados; las pruebas estadísticas se realizaron utilizando el software Rstudio.
Resultados: Los tipos y protólogos permitieron identificar diferencias morfológicas entre ellas. Las pruebas de Royston y Shapiro-Wilk respaldaron la normalidad entre los caracteres evaluados. La prueba de Levene sugiere que no hay diferencias significativas entre los caracteres; finalmente, la correlación de Pearson y el VIF indican ausencia de correlación o colinealidad. El análisis LDA mostró una precisión del 100 % en la asignación de los ejemplares con las asignaciones a priori.
Conclusiones: Las diferencias morfológicas y las pruebas estadísticas, apoyan el reconocimiento de dos entidades distintas, V. oncophora con amplia distribución en el centro de México y V. molinaria con distribución más restringida, mejor conocida hasta la fecha en los estados de México, Michoacán y Morelos.
External beam radiotherapy in treatment of high-volume metastatic hormone-sensitive prostate cancer: clinical case
Authors: Shirokorad V. I. 
Published: November 2023

The standard treatment for metastatic hormone-sensitive prostate cancer does not include external beam radiotherapy (EBRT) and radionuclide therapy with radium-223.The article describes a clinical case of successful use of EBRT and radionuclide therapy with radium-223 in a patient with primary high-volume metastatic hormone-sensitive prostate cancer.The patient received diagnosis of prostate cancer сT3bN1M1b (Gleason score 8 (4 + 4)), stage IV (metastases in the bones, extraperitoneal and intrathoracic lymph nodes; prostate specific antigen (PSA) level was 4280 ng/mL). Between October of 2017 and January of 2018, the patient received 6 cycles of chemohormonal therapy (degarelix + docetaxel). Bilateral orchiectomy was performed on 05.02.2018, and the patient underwent palliative EBRT on cervical vertebrae between 04.10.2017 and 19.10.2017 with total dose of 32.6 Gy (equivalent to 38.5 Gy). The patient received systemic radiotherapy with one injection of samarium oxabifor (153Sm) 40 mCi (21.03.2018) and radium-223 (4 injections once a month (17.04.2018, 15.05.2018, 14.06.2018, 10.07.2018) + 2 injections 1 time per 3 months (October 2018, January 2019)). Partial response was achieved in the form of PSA decrease from 4280 ng/mL (September 2017) to 0.505 ng/mL (May 2019). Palliative EBRT for the prostate and pelvis was performed between 14.11.2018 and 19.12.2018 for total dose of 62.5 Gy (equivalent to 69 Gy). For 2 years remission was observed with PSA level of 0.3–0.5 ng/mL. In December of 2020, biochemical recurrence was diagnosed: PSA level increased from 0.61 ng/mL in October to 1.43 ng/mL on 28.12.2020. The second course of radionuclide therapy with radium-223 5,500 MBq/mL was performed (22.01.2021, 05.03.2021, 02.04.2021) with increase of PSA level to 1.92 ng/mL (May of 2021) and independent decrease to 0.542 ng/mL (June of 2022). In December of 2022, biochemical recurrence was observed with a small increase of PSA level to 1.67 ng/mL. Currently, the disease is stabilized.
Surgical access in treatment of kidney cancer complicated by tumor thrombosis of the inferior vena cava and right atrium
Authors: Komarov R. N. , Rapoport L. M. , Shao M. , Tkachev M. I. , Tlisov B. M. , Zavaruev A. V. , Simonyan A. O. 
Published: November 2023

This article discusses the choice of surgical access in renal cancer complicated by tumor thrombus with invasion into the inferior vena cava and the right atrium. This clinical scenario poses a major challenge to the surgeons, as tumor thrombus can obstruct access to the surgical area and increase the risk of complications. This article discusses various surgical access techniques that can be used in treatment of kidney cancer complicated by tumor thrombus of the inferior vena cava and right atrium, including open surgery, robotic surgery, and minimally invasive techniques. An analysis of factors to consider in selection of the optimal surgical access was perfomed.
Radical prostatectomy in the Russian Federation: features of perioperative management and nuances of technical execution
Authors: Gadzhiev N. K. , Rybalchenko V. A. , Dzhalilov I. B. , Shkarupa D. D. , Shkarupa A. G. , Semeniakin I. V. , Petrov S. B. 
Published: November 2023

Despite constant improvements in radical prostatectomy technique, some questions on standardization of both perioperative management stages and surgical intervention itself remain.We conducted an anonymous online survey of 45 oncological urologists from 15 regions of the Russian Federation who are actively involved in the surgical treatment of patients with prostate cancer.According to the results of the survey, there is huge variability associated, to a great extent, with equipment availability in clinics and the lack of sufficient evidence-based information in some matters of perioperative management.A detailed study of each step of surgical treatment, clinical trials, and involvement of professional societies will contribute to the standardization of perioperative management of patients and radical prostatectomy technique.
Pathogenic <i>BRCA2</i> c.6341del gene variant in a patient with prostatic cancer from the North Ossetia
Authors: Bolieva M. B. , Brovkina O. I. , Khodyrev D. S. , Nikitin A. G. , Epkhiev A. A. , Voronkova L. M. , Gordiev M. G. 
Published: November 2023

Hereditary form of prostate cancer is often caused by pathogenic variants in genes associated with the DNA repair system. Identification of genetic aberrations allows to stratify patients into groups for personalization and improvement of therapy effectiveness. With this approach, it is important to take into account that the frequency of pathogenic variants can vary significantly in different ethnic populations.The article presents a case of metastatic castration-resistant prostate cancer in a carrier of hereditary pathogenic variant in the BRCA2 gene c.6341del (р.Pro2114fs). The results support the need for genetic testing using up-to-date methods capable of detecting rare genetic variants.
The 21 March 2022 Mw 5.1 Tampen Spur Earthquake, North Sea: Location, Moment Tensor, and Context
Authors: Jerkins Annie E. , Oye Volker , Alvizuri Celso , Halpaap Felix , Kværna Tormod 
Published: November 2023

ABSTRACT
The 21 March 2022 Mw 5.1 Tampen Spur earthquake is the largest event in the North Sea over the last 33 yr. The earthquake was recorded by a 10,708 sensors permanent reservoir monitoring system (PRM) deployed at the Snorre field only a few kilometers away from the epicenter. The event was also recorded on regional networks, as well as at teleseismic distances. Here, we take advantage of this large number of observations to relocate this seismic event, estimate a moment tensor, and refine the depth of the earthquake. The different data sets and location methods yield similar locations, suggesting a well-constrained earthquake location with a depth of 22 ± 5 km. Furthermore, a moment tensor is estimated, which indicates a thrust fault mechanism. Deep crustal earthquakes (&gt;20 km) have been documented within several continental rifts, for example, in Basin and Range in the United States and in northern Germany. Studying deep intraplate earthquakes such as the event observed here can offer insights into the rheology and structures in the deeper portions of the crust. This thrust earthquake implies the reactivation of an older fault in the lower crust consistent with the ridge-push forces from the mid-Atlantic ridge. Such brittle failure at depth indicates a lower crust with little to no fluids present at this depth within the Tampen Spur region.