bluuebunny/crossref_metadata_2025_split huggingface dataset:
Myeloma of the jaw bones: A clinicopathologic study of 33 cases
Authors: Lae Marick E. , Vencio Eneida F. , Inwards Carrie Y. , Unni K. Krishnan , Nascimento Antonio G. 
Published: April 2003

AbstractBackground.A clinicopathologic study of 33 cases of plasma cell neoplasm of the jaw bones was performed.Methods.The Mayo Clinic's pathology files through 1995 were reviewed for cases of plasma cell neoplasia involving the jaw bones. Clinical data, radiologic features, and follow‐up data were obtained from the hospitals of origin, referring physicians, and Mayo Clinic files. The histopathologic features of the 33 tumors were studied.Results.There were 21 (64%) male and 12 (36%) female patients, ranging in age from 25 to 81 years (mean, 57.7 years). Twenty‐one tumors (64%) were classified as solitary plasmacytoma of bone (SPB) and 12 (36%) as multiple myeloma (MM). Among the SPB cases, 15 (71%) involved the maxilla, and 14 patients were men, with a mean age of 57.1 years. Abnormal serum protein was found in 22% of patients, and in nine patients (43%) the SPB converted to MM after a median of 20.7 months. Among the MM cases, seven (58%) affected the maxilla, seven patients were men with mean age of 58.3 years, and abnormal serum protein and Bence‐Jones protein were found in 42% and 73% of the patients, respectively. Anaplastic histology was identified in seven (33%) SPB and six (50%) MM tumors, and amyloid was present in eight (38%) SPB and three (25%) MM tumors. Twelve (57%) SPB patients died of the disease after a median disease‐free survival of 6.75 years, and the overall and disease‐free survival rates at 5 and 10 years were 52%, 33%, 33%, and 24%, respectively. All MM patients died of the disease after a median survival of 17.6 months, and the 5‐year and 10‐year survival rates were 8% and zero. Eighty‐six percent of the SPB patients with anaplastic histologic findings died of the disease (average survival, 3.8 years), whereas only 43% of those with classic histologic findings died of the disease (average survival, 11.75 years). Among MM patients, anaplastic histologic findings were associated with a 9‐month average survival (26‐month average survival for MM patients with classic histologic findings).Conclusions.SPB patients seem to have a better prognosis than MM patients, and 43% of SPB tumors convert to MM after an average of 20.7 months. Anaplastic histologic findings seem to be associated with lower survival rates and periods for SPB patients and lower survival periods for MM patients. © 2003 Wiley Periodicals, Inc. Head Neck 25: 000–000, 2003
Intraoperative neck staging using sentinel node biopsy and imprint cytology in oral cancer
Authors: Asthana Sonal , Deo S.V. Suryanarayana , Shukla Nootan K. , Jain Paresh , Anand Mona , Kumar Rajive 
Published: April 2003

AbstractBackground.Nodal status is an important prognostic factor in oral cancer. Sentinel node studies may enable accurate identification of high‐risk nodes without a formal neck dissection. Imprint cytology is an emerging tool to assist in the rapid intraoperative detection of nodal metastases with encouraging results in other solid tumors. This study was planned to evaluate a novel method of intraoperative staging using sentinel node biopsy and intraoperative imprint cytology in oral cancer.Patients and Methods.Thirty‐two cases of oral cancer underwent sentinel node mapping using 1% isosulfan blue during the study period. The sentinel node was sent for evaluation by imprint cytology. The average time taken for reporting was 15 minutes. The result was compared with the final histopathology, which was taken as the “gold standard”.Results.Sentinel nodes (SLN) were identified in 30 cases (93.75% identification rate), with two false negatives. Intraoperative imprint cytology (IIC) could accurately predict the nodal status in 28 of the 30 patients. There was one false‐positive result and one false‐negative result. The overall sensitivity, specificity, and accuracy of IIC were 87.5%, 95.4%, and 93.3 %, respectively.Conclusion.Sentinel node biopsy along with IIC provides a reliable, inexpensive, and accurate method of intraoperative identification of the nodal status in oral cancer. © 2003 Wiley Periodicals, Inc. Head Neck 25: 000–000, 2003
Health profiles and quality of life of 518 survivors of thyroid cancer
Authors: Schultz Pamela N. , Stava Charles , Vassilopoulou‐Sellin Rena 
Published: April 2003

AbstractBackground.Available literature describes the long‐term outcome of thyroid cancer survivors with respect to thyroid cancer but not their overall medical and social well‐being.Methods.Five hundred eighteen thyroid cancer survivors responded to a survey regarding medical and social impacts of their cancer experience.Results.All had surgery, and 417 (80.5%) also had some radiation. Two thirds (64.5%) reported that cancer created health effects varying by gender and passage of time; neurologic, musculoskeletal, and psychologic problems seemed most prominent. They reported more memory loss and psychologic problems than other cancer survivors and more migraine headaches than both other cancer survivors and the general population. Regarding family and work, they integrated well in society overall. However, unsolicited comments by 24.5% of responders disclosed symptoms reminiscent of thyroid hormone imbalance.Conclusion.Thyroid cancer survivors generally report good health long term but describe distinct, lasting medical problems including symptoms of thyroid dysregulation. The extent and manner in which cancer therapy contributes to the health profile of the group merits further inquiry. © 2003 Wiley Periodicals, Inc. Head Neck 25: 000–000, 2003
Ruptured internal jugular vein: A postoperative complication of modified/selected neck dissection
Authors: Cleland‐Zamudio Suzanne S. , Wax Mark K. , Smith James D. , Cohen James I. 
Published: April 2003

AbstractBackground.Postoperative hemorrhage from the internal jugular vein after a modified or selective neck dissection is an infrequent, yet potentially life‐threatening, complication. Despite the increasing frequency of modified or selective neck dissections, this complication has not been previously highlighted in the literature.Setting.Tertiary referral academic center.Material and Methods.The records of six patients who experienced this complication were reviewed and analyzed for risk factors that might predict its occurrence.Results.Common risk factors included postoperative pharyngeal fistula formation, significant tobacco history, and poor nutritional status. A more complete circumferential dissection of the vein low in the neck in the presence of hypopharyngeal fistula may place it at a higher risk for rupture.Conclusions.Patients who have a complete circumferential dissection of the internal jugular vein low in the neck and go on to have fistulas develop may be more prone to internal jugular vein rupture. © 2003 Wiley Periodicals, Inc. Head Neck 25: 000–000, 2003
Argyrophilic nuclear organizer regions in nasopharyngeal carcinoma and paraneoplastic epithelia
Authors: Chen Maohuai , Lee Joseph C. K. , Lo Shikyuen , Shen Jian 
Published: April 2003

AbstractBackground.Nucleolar organizer regions (NORs), which are loops of DNA containing ribosomal RNA genes, have been shown to correlate with cell proliferation and malignant transformation. The diagnostic value of silver staining NORs (AgNORs) in preneoplastic epithelia and nasopharyngeal carcinoma (NPC) by the quantitative assessment of AgNORs proteins is evaluated.Methods.Silver‐staining of NORs was applied to 70 paraffin sections of NPC biopsy specimens, including 29 samples of the adjacent normal glandular epithelia (GE), 19 hyperplastic/dysplastic columnar epithelia (CE) in the adjacent mucosa, 10 hyperplastic/dysplastic squamous epithelia (SE) in the adjacent mucosa, 54 differentiated nonkeratinizing carcinoma (DC), and 16 undifferentiated carcinoma (UC). The morphometric features of AgNORs in preneoplastic epithelia and cancer cells were analyzed by image cytometric analysis and then compared.Results.The AgNOR count, mean AgNOR area, and AgNOR area–count ratio increased significantly from GE to CE to DC or UC. The mean nuclear area, AgNOR area, and AgNOR area–count ratio increased significantly from GE to SE to UC, whereas overlapping AgNOR values were observed between SE and DC. UC had significantly higher values than DC in mean nuclear area, AgNOR area, and AgNOR area–count ratio.Conclusions.The morphometric analysis of AgNORs reflected cell proliferative activity and histologic differentiation of tumor rather than malignant transformation in different nasopharyngeal epithelia and NPC. AgNOR area and AgNOR area–count ratio are the most valuable features for differential diagnosis of normal, preneoplastic, and cancer cells. © 2003 Wiley Periodicals, Inc. Head Neck 25:000–000, 2003
Severe trismus secondary to periosteal osteogenesis after fibula free flap maxillary reconstruction
Authors: Smith Russell B. , Funk Gerry F. 
Published: April 2003

AbstractBackground.Fibula free tissue transfer is routinely used for reconstruction of bony defects in the head and neck. During flap preparation, well‐vascularized periosteum is left adjacent to the proximal vascular pedicle. It is known that periosteum can have significant osteogenic potential in the proper settings. Complications related to periosteal osteogenesis of a fibula free flap pedicle have not been previously reported.Case History.A 12‐year‐old girl with a history of squamous cell carcinoma of the maxilla underwent delayed fibula free flap reconstruction of a maxillary defect. The patient had severe trismus develop postoperatively and was found to have osteogenesis along the vascular pedicle. This bone formed a solid bridge from the maxilla to the mandible. Two resections were required, which included excision of the vascular pedicle, to eliminate further osteogenesis and resolve the patient's trismus.Conclusions.The potential for periosteal osteogenesis does exist with fibula free tissue transfer and can have significant consequences. Potential promoters of osteogenesis should be identified and if possible altered in certain clinical scenarios to prevent complications from new bone growth. © 2003 Wiley Periodicals, Inc. Head Neck 25: 000–000, 2003
A study of the effect of a resistive heat moisture exchanger (trachinaze) on pulmonary function and blood gas tensions in patients who have undergone a laryngectomy: A randomized control trial of 50 patients studied over a 6‐month period
Authors: Jones Andrew Simpson , Young Pamela Elizabeth , Hanafi Zul Bin , Makura Zorustra George Grange , Fenton John Elian , Hughes Joseph Peter 
Published: April 2003

AbstractBackground.Previous work from this department has shown that resistive tracheostomy filters increase the partial pressure of oxygen in capillary blood and also provide a significant amount of heat/moisture exchange. Until now it has not been shown whether there is any long‐term beneficial effect and in particular whether raised tissue oxygenation is maintained using a practical filter device.Methods.We carried out a 6‐month randomized control trial including 50 laryngectomees. Twenty‐five patients were treated with the Liverpool Heat Moisture Exchange device incorporating an airway resistor (Trachinaze). Another 25 patients were treated with a placebo device. Relevant subjective and objective data were collected before and at the end of the study. The objective measurements were capillary oxygen tension (which parallels blood arterial tension), carbon dioxide tension, FEV1, FVC, and PIF. Patients were reviewed at intervals throughout the study. Data were analyzed using the Mann–Whitney U test and the paired t test to test the difference between the active device and placebo at 6 months.Results.Subjective lower airway parameters, including cough, number of chest infections, mucus production, and shortness of breath at rest, were significantly improved in the active group compared with the placebo group. The objective parameters FEV1, FVC, and PIF were not significantly different. Capillary oxygen tension, however, was highly significantly raised in the active group at 6 months.Conclusions.Trachinaze is highly superior to placebo at improving subjective pulmonary parameters, including shortness of breath. It is also superior in its ability to maintain an increased peripheral tissue oxygen tension over a 6‐month period. © 2003 Wiley Periodicals, Inc. Head Neck 25: 000–000, 2003
Learning associations between places and visual cues without learning to navigate: Neither fornix nor entorhinal cortex is required
Authors: Gaffan E.A. , Bannerman D.M. , Healey A.N. 
Published: April 2003

AbstractRats with fornix transection, or with cytotoxic retrohippocampal lesions that removed entorhinal cortex plus ventral subiculum, performed a task that permits incidental learning about either allocentric (Allo) or egocentric (Ego) spatial cues without the need to navigate by them. Rats learned eight visual discriminations among computer‐displayed scenes in a Y‐maze, using the constant‐negative paradigm. Every discrimination problem included two familiar scenes (constants) and many less familiar scenes (variables). On each trial, the rats chose between a constant and a variable scene, with the choice of the variable rewarded. In six problems, the two constant scenes had correlated spatial properties, either Allo (each constant appeared always in the same maze arm) or Ego (each constant always appeared in a fixed direction from the start arm) or both (Allo + Ego). In two No‐Cue (NC) problems, the two constants appeared in randomly determined arms and directions. Intact rats learn problems with an added Allo or Ego cue faster than NC problems; this facilitation provides indirect evidence that they learn the associations between scenes and spatial cues, even though that is not required for problem solution. Fornix and retrohippocampal‐lesioned groups learned NC problems at a similar rate to sham‐operated controls and showed as much facilitation of learning by added spatial cues as did the controls; therefore, both lesion groups must have encoded the spatial cues and have incidentally learned their associations with particular constant scenes. Similar facilitation was seen in subgroups that had short or long prior experience with the apparatus and task. Therefore, neither major hippocampal input–output system is crucial for learning about allocentric or egocentric cues in this paradigm, which does not require rats to control their choices or navigation directly by spatial cues. Hippocampus 2003;13:445–460. © 2003 Wiley‐Liss, Inc.
Comparison of computational models of familiarity discrimination in the perirhinal cortex
Authors: Bogacz Rafal , Brown Malcolm W. 
Published: April 2003

AbstractThis study compares the efficiency and plausibility of published computational models of familiarity discrimination in the perirhinal cortex. Substantial evidence indicates that the perirhinal cortex is involved in both the familiarity discrimination aspect of recognition memory and in perceptual functions involved with representations of complete stimuli (i.e., object identification). Published models of how the perirhinal cortex may perform familiarity discrimination can be divided into two groups. The first group assumes that a proportion of perirhinal neurons form a network specialised just for familiarity discrimination (these models may be based on Hebbian or anti‐Hebbian synaptic plasticity). In contrast, the second group assumes that both familiarity discrimination and learning representations of complete stimuli are performed within a single combined network. This study establishes that when the responses of neurons that provide input to the familiarity discrimination network are correlated (as indicated by experimental data), specialised networks based on anti‐Hebbian learning may recognise the previous occurrence of many more stimuli (i.e., have a capacity up to thousands of times larger) than specialised networks based on Hebbian learning. The currently published combined models do not learn an optimal stimulus representation (they do not fully extract statistically independent features), and hence their capacities are even lower than those of the specialised models based on Hebbian learning. Hence, the combined models published thus far are critically less efficient than the specialised models based on anti‐Hebbian learning. This study also compares the consistency of the models with experimental observations concerning what is known of synaptic plasticity in the perirhinal cortex and the responses of its neurons. Many theoretically important parameters remain undetermined, and experiments are suggested to provide information critical for refining and distinguishing between the various models. However, the above theoretical arguments and currently published data favour the existence of a separate network specialised for familiarity discrimination. Hippocampus 2003;13:494–524. © 2003 Wiley‐Liss, Inc.
Different actions of Gabapentin and baclofen in hippocampus from weaver mice
Authors: Bertrand Sandrine , Morin France , Lacaille Jean‐Claude 
Published: April 2003

AbstractThe pre‐ and postsynaptic effects of baclofen, a broad‐spectrum γ‐aminobutyric acid (GABA)B receptor agonist, and gabapentin, a selective agonist at GABAB receptors composed of GABAB(1a,2) heterodimers, were examined in CA1 pyramidal cells using whole‐cell patch‐clamp recordings in hippocampal slices from different strains of mice. In slices from C57BL/6 mice, by means of GABAB receptors, gabapentin and baclofen activated outward K+ currents at resting membrane potential. In weaver mice with a Kir3.2 channel mutation, baclofen and gabapentin failed to activate postsynaptic K+ currents. However, in littermate controls of weaver mice, gabapentin failed to evoke K+ currents, whereas baclofen activated currents in the same cells. Thus, postsynaptic actions of gabapentin and baclofen on K+ currents are different in this mouse strain. Via presynaptic GABAB receptors, baclofen significantly reduced GABAA inhibitory postsynaptic currents (IPSCs) in slices from C57BL/6 mice, as well as weaver and control mice. In contrast, gabapentin did not affect IPSCs significantly in any group of mice. These results indicate that although baclofen and gabapentin are agonists at postsynaptic GABAB receptors positively coupled to K+ channels, their mechanism of action differs in certain strains of mice, including the weaver wild‐type mice, suggesting a dissociation in their signaling mechanism and coupling to K+ channels. Hippocampus 2003;13:525–528. © 2003 Wiley‐Liss, Inc.
Bacterial meningitis causes two distinct forms of cellular damage in the hippocampal dentate gyrus in infant rats
Authors: Bifrare Yoeng‐Delphine , Gianinazzi Christian , Imboden Hans , Leib Stephen L. , Täuber Martin G. 
Published: April 2003

AbstractBacterial meningitis causes neurological sequelae in up to 50% of survivors. Two pathogens known for their propensity to cause severe neurological damage are Streptococcus pneumoniae and group B streptococci. Some forms of neuronal sequelae, such as learning and memory deficits, have been associated with neuronal injury in the hippocampus. To learn more about hippocampal injury in meningitis, we performed a comparative study in bacterial meningitis due to S. pneumoniae and group B streptococcus, in which 11‐day‐old infant rats were infected intracisternally with either of the two pathogens. Histopathological examination of the neuronal injury in the dentate gyrus of the hippocampus showed that S. pneumoniae caused predominantly classical apoptotic cell death. Cells undergoing apoptosis were located only in the subgranular zone and stained positive for activated caspase‐3 and TUNEL. Furthermore, dividing progenitor cells seemed particularly sensitive to this form of cell death. Group B streptococcus was mainly responsible for a caspase‐3‐independent (and TUNEL‐negative) form of cell death. Compared with the morphological features found in apoptosis (e.g., apoptotic bodies), this form of neuronal death was characterized by clusters of uniformly shrunken cells. It affected the dentate gyrus throughout the blade, showing no preferences for immature or mature neurons. Thus, depending on the infecting agent, bacterial meningitis causes two distinct forms of cell injury in the dentate gyrus. Hippocampus 2003;13:481–488. © 2003 Wiley‐Liss, Inc.
Reactions to familiar and novel objects in infant monkeys with neonatal temporal lesions
Authors: Meunier Martine , Nalwa Vanit , Bachevalier Jocelyne 
Published: April 2003

AbstractAdult monkeys with late temporal lobe damage are known to touch and mouth objects compulsively, even unknown objects. To determine whether infants with early temporal damage display this symptom as well, 9‐month‐old rhesus monkeys with neonatal ablations of either the medial temporal lobe or inferior temporal cortex were exposed to four objects, two familiar and two novel. All operated infants were less active/more withdrawn than controls and showed neither exaggerated object manipulation nor hyperorality. Furthermore, like controls, they touched novel objects less than they touched familiar ones. Thus, infants with neonatal medial or inferior temporal ablations did not display the compulsive exploration evidenced after similar lesions in adulthood and retained some ability to detect novelty despite their known memory impairments. Hippocampus 2003;13:489–493. © 2003 Wiley‐Liss, Inc.
Measuring method of three thermophysical parameters of solids by a thermal probe with instantaneous point contact: Measuring principle
Authors: Takahashi Ichiro , Emori Masaaki 
Published: April 2003

AbstractA new method for instantaneous measurement of three thermophysical parameters of solids in situ is proposed. The measurement principle is based on a transient heat conduction model of a thermal probe point contacting a testing body. The measurement of temperature response has been made using the probe of a sheathed K‐type thermocouple in this experiment. Ratios of both thermal conductivity and thermal effusivity between the probe and the testing body are determined from curve‐fitting with the theoretical response to the measured one. As a result, it is shown that the measurement is reproducible and the accuracies of measured thermophysical parameters are good enough to apply this method to many kinds of solids. © 2003 Wiley Periodicals, Inc. Heat Trans Asian Res, 32(3): 191–201, 2003; Published online in Wiley InterScience (www.interscience.wiley.com). DOI 10.1002/htj.10084
Measuring method of three thermophysical parameters of solids by a thermal probe with instantaneous point contact: Discussion about applicability and measuring conditions
Authors: Takahashi Ichiro , Emori Masaaki 
Published: April 2003

AbstractAn instrument for the measuring method reported in the previous paper is a handy tester for three thermophysical parameters of solids in situ. Discussions about measurement errors caused by not strictly satisfying the measuring conditions, such as size and shape of the testing body, and about optimum initial temperature difference between thermal probe and testing body have been done. As a result of the experiment varying the shape of a probe end, it is shown that the radius of the contacting surface on a testing body has no influence on measuring thermophysical parameters. © 2003 Wiley Periodicals, Inc. Heat Trans Asian Res, 32(3): 202–211, 2003; Published online in Wiley InterScience (www.interscience.wiley.com). DOI 10.1002/htj.10085