bluuebunny/crossref_metadata_2025_split huggingface dataset:
What motivates food workers to adhere with WHO guidelines to combat the COVID-19? A social cognitive theory perspective
Authors: Wang Mingliang , Gong Shunlong , Tang Jin , Weng Zhenlin , Wu Xingtong 
Published: October 2023

BackgroundCOVID-19 has become a public health emergency and pandemic of global concern, and the hundreds of millions of foodborne illnesses that occur each year also wreak havoc on human lives, society and the economy. Promoting workers in food service establishments to adhere to the hygiene practices in the WHO guidelines is a two-birds-one-stone strategy in preventing the spread of COVID-19 and limiting the occurrence of foodborne illness. The aim of this study was to determine the drivers that motivate workers to adhere to hygiene practices based on social cognitive theory.MethodsThe cross-sectional survey targeting food workers using face-to-face interviews was conducted from July to September 2022. Stratified random sampling and convenience sampling were employed to locate survey sites and respondents, respectively. The survey uses a credible questionnaire evaluated by multiple reliability and validity measures. Binary logistic regression was employed to identify significant determinants of adherence to WHO-initiated hygiene practices.ResultsA total of 900 workers were interviewed and 609 valid questionnaires were received. The study showed that the average correct rate of knowledge about hygiene practices was only 51.09%, that perceived non-adherence to hygiene practices was most likely to result in lower customer satisfaction and the spread of COVID-19, and that only about 11.7% of the workers always adhered to hygiene practices. Three of the cognitive dimensions in the personal factors, self-efficacy, risk perception, and knowledge, had significant positive effects on adherence practices. Among the demographic variables, there were significant differences in adherence practices differing by income level and place of residence.ConclusionIt was found that workers’ knowledge of the WHO-initiated hygiene practices is insufficient and that the frequency of adherence to hygiene practices is poor and require improvement. The significant drivers and effects of demographic variables provide evidence-based guidance to identify priority intervention information and populations to improve worker hygiene practices.
Is food produced by farmers healthier, more natural, and gaining more popularity? Research on the influencing mechanism of food producer labels on consumers’ food choices
Authors: Zhu Yong , Jin Xiaotong 
Published: October 2023

IntroductionExtant studies have demonstrated the relationship between naturalness and healthiness, and the effectiveness of various food labels in influencing consumers’ perception of food and subsequent food choices. However, little attention has been given to food producer labels.MethodsDrawing on Stimulation-Organism-Response theory, the current study explored the causal relationship between food producer labels and consumers’ food choices. Three studies (562 participants) were employed to test the main effect, the mediating effect, and the moderating effect.ResultsThe results showed that: (1) food producer label could influence consumers’ food choice, that is, produced-by-farmer label (vs. produced-by-enterprise label vs. control group) could significantly increase consumers’ food choices, while there is no significant difference between produced-by-enterprise label and control group. (2) Perceived naturalness and standardization perception mediate the effects on consumers’ food choices of food producer labels. (3) Food processing level moderates the effect of food producer label on consumers’ food choices.DiscussionThe current study enriches the research of food label and food choice, expands the application of Stimulation-Organism-Response theory in consumer behavior, and provides some practical suggestions for consumers, enterprise and policy-maker. Various kinds of experiments (online and offline) enhanced the conclusions’ ecological validity. Finally, the limitations and future research are discussed.
Public school teachers' occupational stress across different school types: a nationwide survey during the prolonged COVID-19 pandemic in Japan
Authors: Tsubono Kenjiro , Mitoku Sachiko 
Published: October 2023

ObjectivesSchool teaching is regarded as one of the most stressful professions worldwide. To maintain schoolteachers' mental health, the factors influencing occupational stress among schoolteachers must be clarified. This study aimed to investigate public school teachers' work-related stress considering the differences in school types using data from a large-scale nationwide survey conducted during the prolonged coronavirus disease 2019 (COVID-19) pandemic in Japan.MethodsData from a nationwide survey of public school teachers performed between June 2019 and December 2022 were analyzed. The dataset consisted of repeated cross-sectional data. The total number of participants was 270,777 in 2019, 296,599 in 2020, 299,237 in 2021, and 307,866 in 2022. Information on working hours, job demands, workplace support, stress response, and perceived main stressors were assessed for each type of public school.ResultsRegardless of school type, quantitative workload and long working hours were the most significant factors affecting teachers' stress responses. However, stress-related factors among teachers varied significantly between school types. The percentage of junior high school teachers who perceived “extra-curricular club activities” as their main stressor was the highest among all school types. The highest proportion of elementary school teachers perceived “dealing with difficult students” as their main stressor. Meanwhile, interpersonal conflict scores were the highest among special needs school teachers. Teachers' workload and stress levels significantly increased in the third year of the COVID-19 pandemic (2022) compared to the pre-pandemic year (2019) in all school types despite the marginally small score differences.ConclusionsThis study highlighted the importance of reducing teachers' workload for their mental health regardless of school types. Meanwhile, perceived work-related stress among teachers differed significantly between school types. Given the possible prolonged impacts of the pandemic on teachers' occupational stress, teachers' stress levels must be monitored throughout and after the pandemic. The results suggest that increasing the number of schoolteachers and support staff and providing adequate organizational support are necessary to prevent teachers' sick leave due to mental disorders. In addition, taking comprehensive countermeasures against teachers' occupational stress, considering the differences in school types, is crucial for safeguarding schoolteachers' mental health.
Components of navigation ability and their predictors in a community-dwelling sample of older adults
Authors: Prevratil Michael J. , Kossowska-Kuhn Dorota , Gray Nicholas , Charness Neil 
Published: October 2023

Introduction: Navigation, as a complex skill important for independent living, requires a variety of cognitive processes. Current scales tapping components are lengthy and can be burdensome for older adults.Methods: Community-dwelling older adults (n = 380, age 60–90 years) completed an online survey tapping wayfinding, being lost navigating, and needing help navigating. Participants then completed objective measures of navigation ability and self-reported memory ability. Cronbach’s α was calculated for navigation subscales consisting of subsets of the Wayfinding Questionnaire and Santa Barbara Sense of Direction Questionnaire, and an exploratory factor analysis (EFA) was conducted. Regression analyses were used to test whether objective navigation, memory, and demographic information navigation predicted navigation subscale performance.Results: Each of the individual subscales demonstrated high reliability. EFA generated five unique factors: routing, mental mapping, navigation in near vicinities, feeling lost in far vicinities, and needing help in far vicinities. Across regression analyses, memory, gender, and performance on the Spatial Orientation Test were significant predictors.Discussion: Navigation is a multi-faceted construct that can be reliably measured using concise surveys. Further research is necessary to understand the intricacies of aging and navigation.
Quadriceps strength, patellar tendon quality, relative load exposure, and knee symptoms in male athletes before the anterior cruciate ligament reconstruction
Authors: Pereira Carla S. , Klauznicer Jasenko , Maree Dustin , McAuliffe Sean , Farooq Abdulaziz , Whiteley Rod , Finni Taija 
Published: October 2023

IntroductionAnterior cruciate ligament (ACL) injuries cause knee instability, knee pain, weight-bearing adjustments, and functional deficits but their association to patellar tendon quality is unknown. Our purpose was to investigate quadriceps strength, patellar tendon quality, relative load exposure, perceived knee stability, knee pain, extension angle, and time from ACL injury; in addition to examining their relative associations.MethodsInjured and uninjured legs of 81 male athletes of different sports with a unilateral ACL injury (18–45 years) were examined. Participants reported location and intensity of knee pain and their perceived stability using a numerical rating scale (NRS 0–10). Strength was tested with an isokinetic device. Tendon quality was measured using ultrasound tissue characterization. Means ± standard deviation (SD) of perceived knee stability, knee extension angle, knee pain, isokinetic quadriceps strength in relation to body mass, proportion of echo-types (I–IV), tendon volume, and number of days from ACL injury to assessment are reported. Values of effect sizes (ES) and correlations (rs) were calculated.ResultsACL injured leg demonstrated reduced reported knee stability (6.3 ± 2.5), decreased knee extension angle (−0.7 ± 3.1° vs. −2.7 ± 2.2°; ES = 0.7; P &lt; 0.001), greater knee pain (NRS 3.1 ± 2.2 vs. 0.0 ± 0.1; ES = 2.0; P &lt; 0.001), and 22% lower quadriceps strength (228.0 ± 65.0 vs. 291.2 ± 52.9 Nm/kg: ES = 1.2; P &lt; 0.001) as compared to the uninjured leg. However, patellar tendons in both legs displayed similar quality. Quadriceps strength was associated with stability (rs = −0.54; P &lt; 0.001), pain (rs = −0.47; P &lt; 0.001), extension angle (rs = −0.39; P &lt; 0.001), and relative load exposure (rs = −0.34; P &lt; 0.004). Echo-types distribution was beneficially associated with time from ACL injury (rs range: −0.20/ −0.32; P &lt; 0.05).DiscussionACL injured athletes displayed knee pain, extension deficit, and weaker quadriceps in the injured leg. While there were no differences in patellar tendon quality between legs, longer time from ACL injury showed better tendon quality.
Genetic analysis of the equine orthologues for human CYP2D6: unraveling the complexity of the CYP2D family in horses
Authors: Scantamburlo Giada , Nofziger Charity , Paulmichl Markus , Vanoni Simone 
Published: October 2023

IntroductionBecause of their importance as companion animals or as racehorses, horses can be treated with various drugs. Although it is known that drug withdrawal times can vary for each horse, pharmacogenetics for these animals has not been adequately studied and requires further development. Since CYP2D6 is responsible for the metabolism of 25–30% of drugs in humans, including some used to treat horses, a study of the CYP2D family in horses was conducted to define its genetic structure as well as its expression pattern in the liver.MethodsGenomic DNA extracted from venous blood and mRNA from fresh liver tissue were amplified and sequenced to analyze the genomic structure, genotype, and expression of the various enzymes that are part of the equine orthologous family for CYP2D6.ResultsAmplification and sequencing of the gDNA of CYP2D50, the major CYP2D6 orthologue identified in previous studies, revealed a novel putative genomic structure for this gene compared with that reported from the EquCab3.0 assembly, including the formation of a hybrid structure similar to what happens in human CYP2D6. At the mRNA level, transcripts from six different members of the equine CYP2D family were detected in horse liver. In addition, genotyping of CYP2D50 and CYP2D82 revealed the presence of several polymorphisms, six of which result in novel, nonsynonymous amino acid changes for each of the two genes.DiscussionThis study aimed to elucidate the pharmacogenetic analysis of the CYP2D family in horses and resulted in the identification of a novel gene structure for CYP2D50, the expression of six different members of the CYP2D family in horse liver, and several novel polymorphisms for CYP2D50 and CYP2D82.
Zoonotic diseases transmitted from the camels
Authors: Khalafalla Abdelmalik Ibrahim 
Published: October 2023

BackgroundZoonotic diseases, infections transmitted naturally from animals to humans, pose a significant public health challenge worldwide. After MERS-CoV was discovered, interest in camels was raised as potential intermediate hosts for zoonotic viruses. Most published review studies pay little attention to case reports or zoonotic epidemics where there is epidemiological proof of transmission from camels to humans. Accordingly, any pathogen found in camels known to cause zoonotic disease in other animals or humans is reported.MethodsHere, zoonotic diseases linked to camels are reviewed in the literature, focusing on those with epidemiological or molecular evidence of spreading from camels to humans. This review examines the risks posed by camel diseases to human health, emphasizing the need for knowledge and awareness in mitigating these risks.ResultsA search of the literature revealed that eight (36.4%) of the 22 investigations that offered convincing evidence of camel-to-human transmission involved MERS, five (22.7%) Brucellosis, four (18.2%) plague caused by Yersinia pestis, three (13.6%) camelpox, one (4.5%) hepatitis E, and one (4.5%) anthrax. The reporting of these zoonotic diseases has been steadily increasing, with the most recent period, from 2010 to the present, accounting for 59% of the reports. Additionally, camels have been associated with several other zoonotic diseases, including toxoplasmosis, Rift Valley fever, TB, Crimean-Congo hemorrhagic fever, and Q fever, despite having no evidence of a transmission event. Transmission of human zoonotic diseases primarily occurs through camel milk, meat, and direct or indirect contact with camels. The above-mentioned diseases were discussed to determine risks to human health.ConclusionMERS, Brucellosis, plague caused by Y. pestis, camelpox, hepatitis E, and anthrax are the main zoonotic diseases associated with human disease events or outbreaks. Transmission to humans primarily occurs through camel milk, meat, and direct contact with camels. There is a need for comprehensive surveillance, preventive measures, and public health interventions based on a one-health approach to mitigate the risks of zoonotic infections linked to camels.
The Role of Cancer in the Risk of Cardiovascular and All-Cause Mortality: A Nationwide Prospective Cohort Study
Authors: Shen Ruihuan , Wang Jia , Wang Rui , Tian Yuqing , Guo Peiyao , Shen Shuhui , Liu Donghao , Zou Tong 
Published: October 2023

Objectives: Evidence on cardiovascular-related and all-cause mortality risks in a wide range of cancer survivors is scarce but needed to inform prevention and management.Methods: We performed a nationwide prospective cohort study using information from the Continuous National Health and Nutrition Examination Survey (NHANES) in the United States and the linked mortality follow-up files, available for public access. A propensity score-matched analysis with a 1:1 ratio was conducted to reduce the baseline differences between participants with and without cancer. The relationship between cancer status and the cardiovascular-related and all-cause mortality risk was examined using weighted Cox proportional hazards regression. Independent stratification analysis and cancer-specific analyses were also performed.Results: The study sample included 44,342 participants, aged 20–85, interviewed between 1999 and 2018. Of these, 4,149 participants had cancer. All-cause death occurred in 6,655 participants, of whom 2,053 died from cardiovascular causes. Propensity-score matching identified 4,149 matched pairs of patients. A fully adjusted Cox proportional hazards regression showed that cancer was linked to an elevated risk of cardiovascular-related and all-cause mortality both before and after propensity score matching. Stratification analysis and cancer-specific analyses confirmed robustness of results.Conclusion: Our study confirmed that cancer was strongly linked to cardiovascular-related and all-cause mortality, even after adjusting for other factors that could impact a risk, including the American Heart Association (AHA)’s Life’s Simple 7 cardiovascular health score, age, sex, ethnicity, marital status, income, and education level.
Transcriptomic Analysis on Pectoral Muscle of European Meat Pigeons and Shiqi Pigeons during Embryonic Development
Authors: Li Fada , Zhu Chenyu , Luo Yongquan , Li Songchao , Wang Qi , Han Yuanhao , Wu Zhongping , Li Xiujin , Liang Yayan , Chen Yitian , Shen Xu , Huang Yunmao , Tian Yunbo , Zhang Xumeng 
Published: October 2023

In avian muscle development, embryonic muscle development determines the number of myofibers after birth. Therefore, in this study, we investigated the phenotypic differences and the molecular mechanism of pectoral muscle development of the European meat pigeon Mimas strain (later called European meat pigeon) and Shiqi pigeon on embryonic day 6 (E6), day 10 (E10), day 14 (E14) and day 1 after birth (P1). The results showed that the myofiber density of the Shiqi pigeon was significantly higher than that of the European meat pigeon on E6, and myofibers with a diameter in the range of 50~100 μm of the Shiqi pigeon on P1 were significantly higher than those of European meat pigeon. A total of 204 differential expressed genes (DEGs) were obtained from RNA-seq analysis in comparison between pigeon breeds at the same stage. DEGs related to muscle development were found to significantly enrich the cellular amino acid catabolism, carboxylic acid catabolism, extracellular matrix receptor interaction, REDOX enzyme activity, calcium signaling pathway, ECM receptor interaction, PPAR signaling pathway and other pathways. Using Cytoscape software to create mutual mapping, we identified 33 candidate genes. RT-qPCR was performed to verify the 8 DEGs selected—DES, MYOD, MYF6, PTGS1, MYF5, MYH1, MSTN and PPARG—and the results were consistent with RNA-seq. This study provides basic data for revealing the distinct embryonic development mechanism of pectoral muscle between European meat pigeons and Shiqi pigeons.
Phloem-Mobile MYB44 Negatively Regulates Expression of PHOSPHATE TRANSPORTER 1 in Arabidopsis Roots
Authors: Olukayode Toluwase , Chen Jieyu , Zhao Yang , Quan Chuanhezi , Kochian Leon V. , Ham Byung-Kook 
Published: October 2023

Phosphorus (P) is an essential plant macronutrient; however, its availability is often limited in soils. Plants have evolved complex mechanisms for efficient phosphate (Pi) absorption, which are responsive to changes in external and internal Pi concentration, and orchestrated through local and systemic responses. To explore these systemic Pi responses, here we identified AtMYB44 as a phloem-mobile mRNA, an Arabidopsis homolog of Cucumis sativus MYB44, that is responsive to the Pi-starvation stress. qRT-PCR assays revealed that AtMYB44 was up-regulated and expressed in both shoot and root in response to Pi-starvation stress. The atmyb44 mutant displayed higher shoot and root biomass compared to wild-type plants, under Pi-starvation conditions. Interestingly, the expression of PHOSPHATE TRANSPORTER1;2 (PHT1;2) and PHT1;4 was enhanced in atmyb44 in response to a Pi-starvation treatment. A split-root assay showed that AtMYB44 expression was systemically regulated under Pi-starvation conditions, and in atmyb44, systemic controls on PHT1;2 and PHT1;4 expression were moderately disrupted. Heterografting assays confirmed graft transmission of AtMYB44 transcripts, and PHT1;2 and PHT1;4 expression was decreased in heterografted atmyb44 rootstocks. Taken together, our findings support the hypothesis that mobile AtMYB44 mRNA serves as a long-distance Pi response signal, which negatively regulates Pi transport and utilization in Arabidopsis.
Predicting early orthodontic treatment results and development of the dentofacial system without orthodontic treatment in 3-12-year-old children
Authors: Shishmareva A. S. , Bimbas E. S. , Limanovskaya O. V. 
Published: October 2023

Relevance.Prognosis of the dentofacial system (DS) development in children with dentofacial deformities (DD) is an urgent medical and social problem since the prognosis of the DS development will allow timely prescription and provision of adequate therapy, which will significantly reduce the risks of severe DD development in children. Machine learning methods have proven to be a reliable tool for predicting a patient's health status and evaluating the effectiveness of treatment methods. Therefore, it seems interesting to use this modern toolkit to build predictive models that allow us to assess the change in the condition of DS in children with DD after orthodontic treatment (OT) at different ages or without OT.Purpose.The study aimed to build a set of predictive models for assessing the severity of the dentofacial system condition in 3.5-4-year-old children after and without orthodontic treatment.Material and methods.The study used the data on the DS of children aged 3-5 years (n=50), 6-9 years (n=100), 10-12 years (n=100) and 13-17 years (n =100). The author's program was developed in Python 3.11 using the sklearn, pandas, and xgb libraries in Anaconda to build the predictive models.Results.We developed nine models of the DS condition in children aged 3-12 years, three of which make predictions for the DS development after the OT (one - in the group of 3 – 5-year-old children, the second – in the group of 6 – 9-year-old children and the third – in the group of 10 – 12-year-olds) and six models predict the development of the DS without OT. Three out of 6 models predict DS development without OT at 3-5 years: the first makes a prediction of the DS condition for 6-9 year-olds; the second – for 10-12 year-olds; the third – for 13-17-year-olds. The accuracy of the models ranges from 82 to 86%. Two models out of 6 predict the DS development for children with DD who did not receive OT at 6-9 years old: one – at 10-12 years old, the second – at 13-17 years old. The accuracy of the models ranges from 92 to 97%. The sixth model makes predictions of the DS condition in children aged 13-17 years who did not receive OT at the age of 10-12 years. The accuracy of the model is 94%. In addition, we built three models that predict the DS condition in 3.5-4 years after the OT: the first model predicts for 3–5-year-old children; the second – for 6–9-year-olds; and the third - for children of 10–12 years old. The accuracy of the models ranges from 82 to 90%.Conclusion.All obtained models will be used to build a web application for predicting the DS state severity in children after the orthodontic treatment and without the latter.