bluuebunny/crossref_metadata_2025_split huggingface dataset:
Investigation of Phytochemical, Antioxidant and Antidiabetic Potentials of Scabiosa L. (Caprifoliaceae) Species with Chemometric Methods
Authors: Albayrak Sevil , Aksoy Ahmet , Yilmaz Mustafa Abdullah , Beyzi Erman 
Published: January 2024

AbstractIn this research, the total phenolic and flavonoid amounts, phenolic compositions, in vitro antioxidant, antibacterial and antidiabetic properties of the methanol extracts obtained from Scabiosa L. (Caprifoliaceae) species distributed in the flora of Türkiye were investigated using chemometric methods. For this purpose, principal component (PCA) and agglomerative hierarchical clustering analysis were performed as chemometric methods. Chlorogenic acid, quinic acid and cyranoside were determined in the extracts. According to chemometric analysis, S. columbaria subsp. ochroleuca var. ochroleuca and S. triniifolia species were found to be valuable in terms of methanol extract yields, total phenolic and flavonoid contents, antioxidant and antidiabetic activities while S. columbaria subsp. ochroleuca var. webbiana species were found to be valuable in terms of phenolic composition. The methanol extracts of Scabiosa species showed high antioxidant activity, with high phenolic and flavonoid contents. Among the tested 13 bacteria, Scabiosa extracts showed only low activity against Klebsiella pneumoniae, Streptococcus pneumoniae and Pseudomonas aeruginosa. The extracts showed high α‐amylase and α‐glucosidase inhibitory activity. The results show that Scabiosa methanol extracts may be a source of alternative antioxidants that may be beneficial in slowing or preventing the progression of various oxidative stress‐related diseases.
Eco‐Friendly Bio‐Based Solvents for the Acetylation of the Amino Group of Amino Acids
Authors: Cazzaniga Giulia , Tresoldi Andrea , Gelain Arianna , Meneghetti Fiorella , Mori Matteo , Villa Stefania 
Published: January 2024

AbstractNature‐derived products, like juices and peel extracts of fruits and vegetables, have emerged in recent years as interesting and sustainable alternatives to traditional solvents in several synthetic applications. Herein, we present a green and fast method for the N‐acetylation of amino acids, using several bio‐based solvents (vinegar, tomato/kiwi/apple peel extracts, lemon juice, etc.). The high reactivity of the amino group is often a limitation in synthetic processes, making its protection a necessary step to achieve pure products and limit side reactions. Therefore, versatile, time‐efficient procedures, minimal purification efforts, and good yields are desirable features for these transformations. Our new method meets all these criteria, offering a valuable and eco‐friendly alternative to traditional approaches. In detail, we managed to obtain comparable yields to established setups, while improving safety and reducing the environmental impact of the overall process. Most notably, the milder conditions made it possible to avoid the use of running water (saving about 250 L/reaction) and electric‐powered cooling devices.
Electrochemical Behavior of Quinones Classically Used for Bioenergetical Applications: Considerations and Insights about the Anodic Side
Authors: Longatte Guillaume , Buriez Olivier , Labbé Eric , Guille‐Collignon Manon , Lemaître Frédéric 
Published: January 2024

AbstractQuinones are electrochemical probes which are used for a large range of applications including bioenergetics. One electrochemical feature of quinones is their possible slow electron transfer kinetics. In this article we compared several quinones towards electron transfer kinetics and the ability of anodic pretreatment to increase electron transfer rate constant. Rotating disk electrode and chronoamperometry measurements were used to revisit their electrochemical behavior. Additionally, the number of electrons exchanged as a function of the characteristic time was used as a proxy to investigate kinetic limitations. A model was suggested to rationalize our results. Beyond a classification of quinones regarding the kinetic and thermodynamic ability of the hydroquinone form to be re‐oxidized, some intrinsic physicochemical properties were identified from our model (such as a time dependency of the exchanged number of electrons) to characterize such important redox mediators.
Graphene oxide nanosheets enhancing the photothermal response of a cellular barrier exposed to near infrared light
Authors: Lu Chao , Tang Howyn , Zhang Jin 
Published: January 2024

AbstractRecent developments in targeted photothermal therapy focus on integrating near‐infrared (NIR) light and biocompatible nanostructures. It is yet unclear if graphene oxide nanosheets (GO) can assist in the photothermal response of cellular barriers under NIR irradiation. Herein, this study investigates the photothermal response of a cellular barrier treated with different concentrations of GO under the irradiation of NIR light. The synthesized GO nanosheets show good stability in aqueous media. No toxic effects are imposed onto human umbilical vein endothelial cells (HUVECs) when the cells are treated with GO up to 20 μg/mL for 1 day. In addition, the in vitro cellular barrier model with intercellular tight junctions is formed by using HUVECs, which have a high transepithelial electrical resistance (TEER) value of 89.3 Ω · cm2. Under the irradiation of NIR light (980 nm), the photothermal response on the cellular barrier is enhanced by introducing GO, which has been verified by the decrease of TEER value and the increase in the transport of dextran. The results indicate that the thermal response of a cellular barrier exposed to NIR light is non‐linearly enhanced with increasing concentration of GO.
QRS fragmentation does not predict mortality in survivors of acute myocardial infarction
Authors: Allescher Julia , Sinnecker Daniel , von Goeldel Bernhard , Barthel Petra , Müller Alexander , Hapfelmeier Alexander , Martens Eimo , Laugwitz Karl‐Ludwig , Schmidt Georg , Steger Alexander 
Published: January 2024

AbstractBackgroundDespite advances in coronary revascularization and in heart failure management, myocardial infarction survivors remain at substantially increased mortality risk. Precise risk assessment and risk‐adapted follow‐up care are crucial to improve their outcomes. Recently, the fragmented QRS complex, i.e. the presence of additional spikes within the QRS complexes on a 12‐lead electrocardiogram, has been discussed as a potential non‐invasive risk predictor in cardiac patients.HypothesisThe aim of this study was to evaluate the prognostic meaning of the fragmented QRS complex in myocardial infarction survivors.Methods609 patients with narrow QRS complexes <120 ms were included in a prospective cohort study while hospitalized for myocardial infarction and followed for 5 years.ResultsThe prevalence of the fragmented QRS complex in these patients amounted to 46.8% (285 patients). These patients had no increased hazard of all‐cause death (HR 0.84, 95%–CI 0.45–1.57, p = 0.582) with a mortality rate of 6.0% compared to 7.1% in patients without QRS fragmentations. Furthermore, the risks of cardiac death (HR 1.28, 95%–CI 0.49–3.31, p = 0.613) and of non‐cardiac death (HR 0.6, 95%–CI 0.26–1.43, p = 0.25) were not significantly different in patients with QRS fragmentations. However, patients with QRS fragmentations had increased serum creatine kinase concentrations (1438U/l vs. 1160U/l, p = 0.039) and reduced left ventricular ejection fractions (52% vs. 54%, p = 0.011).ConclusionsThe hypothesis that QRS fragmentation might be a prognostic parameter in survivors of myocardial infarction was not confirmed. But those with QRS fragmentation had larger myocardial infarctions, as measured by creatine kinase and left ventricular ejection fraction.
Synthesis, characterization of novel N‐(4‐cyano‐1,3‐oxazol‐5‐yl)sulfonamide derivatives and in vitro screening their activity against NCI‐60 cancer cell lines
Authors: Severin Oleksandr , Pilyo Stepan , Kachaeva Maryna , Zhirnov Victor , Hodyna Diana , Bahrieieva Oksana , Brovarets Volodymyr 
Published: January 2024

AbstractA novel series of N‐(4‐cyano‐1,3‐oxazol‐5‐yl)sulfonamides have been synthesized and characterized by IR, 1H NMR, 13C NMR spectroscopy, elemental analysis and chromato‐mass‐spectrometry. The anticancer activities of all newly synthesized compounds were evaluated via a single high‐dose assay (10 μM) against 60 cancer cell lines by the National Cancer Institute (USA) according to its screening protocol. Among them, compounds 2 and 10 exhibited the highest activity against the 60 cancer cell lines panel in the one‐dose assay. Compounds 2 and 10 showed inhibitory activity within the GI50 parameter and in five dose analyses. However, their cytostatic activity was only observed against some cancer cell lines, and cytotoxic concentration was outside the maximum used, i. e., >100 μM. The COMPARE analysis showed that the average graphs of the tested compounds have a moderate positive correlation with compounds with the L‐cysteine analog and vinblastine (GI50) as well as paclitaxel (TGI), which target microtubules. Therefore, disruption of microtubule formation may be one of the mechanisms of the anticancer activity of the tested compounds, especially since among tubulin inhibitors with antitumor activity, compounds with an oxazole motif are widely represented. Therefore, N‐(4‐cyano‐1,3‐oxazol‐5‐yl)sulfonamides may be promising for further functionalization to obtain more active compounds.
Evaluation and comparison of patient satisfaction with VertexThermosens and conventional acrylic complete dentures
Authors: Alidema Sebahate H. , Halili Rajmonda 
Published: January 2024

AbstractObjectivesPatient perception and satisfaction with dentures are important indicators in prosthodontic treatment. This study aimed to compare patients' satisfaction with VertexThermosens dentures versus conventional acrylic dentures during a 12‐month study period.Material and MethodsThis randomized study involved 60 participants aged between 45 and 80 with representation of both sexes. The patients were divided into two groups: The first group (experimental group), which had complete dentures from VertexThermosens base material included 30 participants. The second group (control group), which had complete dentures from convectional rigid acrylic base material, included 30 participants. Patient satisfaction with the dentures was assessed in each of the two Vertex/Acrylic groups through a specially created questionnaire of five questions with a five‐point Likert scale of possible answers (0 = never; 1 = rarely; 2 = occasionally; 3 = often; and 4 = very often).ResultsAfter 12 months, intergroup comparison with Mann–Whitney U Test related to Q2 (p = 0.193), Q3 (p = 0.960), Q4 (p = 0.317), Q5 (p = 1.000) patient satisfactions indicated that there was no significant difference between the two groups (Vertex/Acrylic), except Q1 (p = 0.010) question, Vertex group was more satisfied. The results regarding the patients of both groups (Vertex/Acrylic) showed that after 12 months of wearing the denture, the satisfaction level regarding to all questions increased, except Q5‐question for Vertex group, where the difference was not significant due to the already achieved maximum satisfaction at zero time.ConclusionBased on the findings of this clinical study, it can be concluded that higher satisfaction is seen in patients rehabilitated with VertexThermosens dentures than with conventional rigid acrylic dentures.
Development and validation of the Iranian version of the Children's Experiences of Dental Anxiety Measure (CEDAM)
Authors: Enshaei Zahra , Kaji Kimia Sadeghi , Saied‐Moallemi Zahra 
Published: January 2024

AbstractObjectiveThe aim of this study was to develop the Iranian version of the Children's Experiences of Dental Anxiety Measure (CEDAM) and evaluate its validity and reliability in assessing dental anxiety in children aged 9‒16.MethodsThe CEDAM was translated into Persian following the guidelines of the IQOLA project. A ‎sample of children completed the measure in a clinical setting, with a subgroup completing it ‎again to assess test–retest reliability. Concurrent criterion validity was evaluated by having all ‎participants complete the Modified Child Dental Anxiety Scale (MCDAS) alongside the ‎CEDAM. Construct validity was examined using exploratory and confirmatory factor ‎analyses.‎ResultsThe study included 275 children between the ages of 9 and 16. The Iranian version of CEDAM ‎exhibited excellent internal consistency with a Cronbach's ⍺ coefficient of 0.83. Test–retest ‎reliability was also high, with an intraclass correlation coefficient value of 0.96. Furthermore, there was a significant and ‎positive correlation between CEDAM and MCDAS scores (ρ = 0.72, p < .01). Exploratory ‎factor analysis identified two factors, and confirmatory factor analysis confirmed that the ‎instrument aligned well with the factor structure obtained from the exploratory analysis.‎ConclusionThis study provides evidence supporting the validity and reliability of the Iranian version of ‎CEDAM as a valuable tool for evaluating dental anxiety in Persian‐speaking children between ‎the ages of 9 and 16.‎
Digital versus conventional surgical guide fabrication: A randomized crossover study on operator preference, difficulty, effectiveness, and operating time
Authors: Donker Vincent J. J. , Heijs Karel H. , Pol Christiaan W. P. , Meijer Henny J. A. 
Published: January 2024

AbstractAimIf surgical guide fabrication is introduced in a dental education program, a digital and conventional workflow can be used. This study evaluated operator preference, perceived difficulty and effectiveness and operating time of both fabrication methods.Materials and MethodsForty participants in a university setting (students, n = 20; dentists, n = 20) with varying levels of dental experience, but no experience in surgical guide fabrication, were randomly assigned to consecutively fabricate surgical guides on a standardized training model, with either the digital or conventional workflow first. The operating time was measured, and operator preference and the perception of difficulty and effectiveness were assessed with a questionnaire. T tests were used for statistical analysis (α = .05).ResultOf the students, 95% preferred the digital workflow and of the dentists 70%. The perceived difficulty of the digital workflow was significantly lower than the conventional workflow in the student group. Both groups perceived the digital workflow to be more effective. The mean operating time (mm:ss) amounted 12:34 ± 2:24 (students) and 18:07 ± 6:03 (dentists) for the digital, and 22:20 ± 3:59 (students) and 20:16 ± 4:03 (dentists) for the conventional workflow.ConclusionBoth students and dentists prefer the digital workflow for surgical guide fabrication. Students perceive the digital workflow as less difficult and more effective than the conventional workflow. The operating time for surgical guide fabrication is shorter with a digital workflow. This study indicates that digital fabrication techniques for surgical guides are preferred to be incorporated into the dental curriculum to teach students about treatment planning in implant dentistry.
Tapping the Full Potential of Infrared Spectroscopy for the Analysis of Technical Lignins
Authors: Sumerskii Ivan , Böhmdorfer Stefan , Tsetsgee Otgontuul , Sulaeva Irina , Khaliliyan Hajar , Musl Oliver , Dorninger Katharina , Tischer Alexander , Potthast Karin , Rosenau Thomas , Brereton Richard G. , Potthast Antje 
Published: January 2024

AbstractWe present an approach to overcome the challenges associated with the increasing demand of high‐throughput characterization of technical lignins, a key resource in emerging bioeconomies. Our approach offers a resort from the lack of direct, simple, and low‐cost analytical techniques for lignin characterization by employing multivariate calibration models based on infrared (IR) spectroscopy to predict structural properties of lignins (i. e., functionality, molar mass). By leveraging a comprehensive database of over 500 well‐characterized technical lignin samples – a factor of 10 larger than previously used sets – our chemometric models achieved high levels of quality and statistical confidence for the determination of different functional group contents (RMSEPs of 4–16 %). However, the statistical moments of the molar mass distribution are still best determined by size‐exclusion chromatography. Analyses of over 500 technical lignins offered also a great opportunity to provide information on the general variability in kraft lignins and lignosulfonates (from different origins). Overall, the effected savings in analysis time (>7 h), resources, and required sample mass combined with non‐destructiveness of the measurement satisfy key demands for efficient high‐throughput lignin analyses. Finally, we discuss the advantages, disadvantages, and limitations of our approach, along with critical insights into the associated chemical‐analytical and spectroscopic challenges.
Current feedback operational amplifier‐based fully orthogonal universal and multifunction filters
Authors: Dogan Mehmet , Minayi Elham , Yuce Erkan , Minaei Shahram 
Published: January 2024

SummaryThis paper introduces a second‐order voltage‐mode (VM) multiple‐input single‐output (MISO) universal filter and a second‐order current‐mode (CM) single‐input multiple‐output (SIMO) multifunction filter. The introduced VM MISO universal filter includes a single current feedback operational amplifier (CFOA) and a single voltage follower as active elements, while the introduced CM SIMO multifunction filter contains two CFOAs. Both introduced circuits are orthogonally controllable. In other words, the quality factors can be controlled through a single resistor without affecting the resonance frequencies. Both circuits have low sensitivities and no passive element‐matching conditions. The introduced VM MISO universal filter has a low output impedance. Moreover, to extract the output currents of the proposed CM SIMO from high impedance terminals, second‐generation current conveyor‐based version of the circuit is introduced. Simulations are made through the PSPICE program, where 0.13‐μm IBM CMOS technology parameters are utilized. DC supply voltages are selected as ±0.9 V. In the experiments, AD844s are used, and DC supply voltages are chosen as ±7.5 V.
Novel six‐phase ring voltage controlled oscillator with wide frequency tuning range
Authors: Hemmati Mohammad Jafar , Dehghani Rasoul 
Published: January 2024

SummaryThis paper presents more compatible three‐stage inverter‐based ring voltage controlled oscillators (VCOs) by modifying the current‐starved delay cell to oscillate with high tuning range. Unlike some ring structures in which extra transistors are used as current boosting to enhance the frequency tuning range, no extra elements are used in the proposed three‐stage VCOs for increasing the tuning range. Besides, a new method is introduced to couple two proposed ring VCOs for designing a six‐phase ring VCO. The coupling method can be generalized to some other ring VCOs to generate multiphase signals. The proposed circuits have wide frequency tuning ranges and show good noise performances. The proposed six‐phase VCO can oscillate from 1.62 GHz to 3.45 GHz, which illustrates 72.2% tuning range. The phase noise of the proposed VCO is −97.5 dBc/Hz at 1 MHz offset frequency. The circuit figure of merit is −181.5 dBc/Hz. The post‐layout simulation results of the proposed six‐phase VCO are provided based on the TSMC 0.18 μm CMOS process.
The Ethics of Using News Stories concerning Minors as Empirical Material in Health Research: Reflections on a Swedish Case
Authors: Stjernswärd Sigrid , Tilgmann Carola , Glasdam Stinne 
Published: January 2024

ABSTRACTIn 2021, we were designing a research study in Sweden in which we planned to use newspaper articles focusing on children and adolescents under the age of eighteen during the Covid‐19 pandemic as empirical material. As we developed this study, an ethical question arose: do studies using journalistic articles that may contain health information about individuals as empirical material have to be approved by an ethics review committee? Sweden, in contrast to other countries, requires the approval of an ethics review committee for the use of publicly available material in research when such material might include sensitive personal data such as health‐related information. This case study calls for harmonized laws and policies that support global research by clarifying what kinds of empirical material and what types of research must be assessed by national ethics review committees, including with consideration for children's safety and rights.
Minisci‐Type Carbamoylation of Azauracils with Oxamic Acids
Authors: Pan Changduo , Chen Dongdong , Zeng Miao , Tian Haoyang , Yu Jin‐Tao 
Published: January 2024

AbstractA Minisci‐type carbamoylation of azauracils was developed to afford 6‐carbamoyl azauracils in yields up to 94 %. In this transformation, oxamic acids were employed as the carbamoyl radical sources under metal‐free conditions. It features high atom economy, good functional group compatibility and convenient operation.
Rose‐Bengal‐Photocatalyzed Cross‐Dehydrogenative Coupling Reactions under Visible Light
Authors: Patel Divyani P. , Kumar Singh Satish 
Published: January 2024

AbstractOver the past few years, organic chemistry has used the organic dye rose bengal‘s ability to absorb visible light. In present‐day research, the innovation of environmentally friendly processes for carbon‐carbon/carbon‐heteroatoms (Nitrogen, Oxygen, Sulphur, and Phosphorus) bond formation has great importance. The photocatalyzed cross‐dehydrogenative coupling (CDC) reactions using rose bengal (RB) is a promising technique for creating carbon‐carbon/carbon‐heteroatom bonds directly from readily available compounds. Our review focuses on the current advancement in rose bengal that uses photocatalyzed carbon‐carbon/carbon‐heteroatom bond‐making reactions to synthesize various important organic molecules via CDC reactions.
Transition‐Metal‐Catalysed Transfer Hydrogenation Reactions with Glycerol and Carbohydrates as Hydrogen Donors
Authors: Ansari Mohd Farhan , Anshika  , Sortais Jean‐Baptiste , Elangovan Saravanakumar 
Published: January 2024

AbstractCatalytic transfer hydrogenation is a practical approach for reduction of various unsaturated compounds and an alternative to pressurised hydrogenation and traditional metal hydride reagents. Among the various hydrogen donors, biomass such as glycerol and carbohydrates received considerable attention for the reduction reactions due to their non‐toxic, eco‐friendly and renewable nature. The present review addresses the development of homogeneous and heterogeneous catalysts for the transfer hydrogenation of carbonyl compounds, alkenes, alkynes, nitro compounds, CO2 etc. using glycerol and carbohydrates as potential hydrogen donors.