bluuebunny/crossref_metadata_2025_split huggingface dataset:
Association of European Paediatric and Congenital Cardiology practical recommendations for surveillance and prevention of cardiac disease in childhood cancer survivors: the importance of physical activity and lifestyle changes From the Association of European Paediatric and Congenital Cardiology Working Group Sports Cardiology, Physical Activity and Prevention, Working Group Adult Congenital Heart Disease, Working Group Imaging and Working Group Heart Failure
Authors: Kesting Sabine , Giordano Ugo , Weil Jochen , McMahon Colin J. , Albert Dimpna C. , Berger Claire , Budts Werner , Fritsch Peter , Hidvégi Erzsébet V. , Oberhoffer-Fritz Renate , Milano Giuseppe M. , Wacker-Gußmann Annette , Herceg-Čavrak Vesna 
Published: January 2024

AbstractBackground:Childhood cancer survivors are at increased risk of developing cardiovascular diseases, presenting as the main causes of morbidity and mortality within this group. Besides the usual primary and secondary prevention in combination with screening during follow-up, the modifiable lifestyle factors of physical activity, nutrition, and body weight have not yet gained enough attention regarding potential cardiovascular risk reduction.Objective:These practical recommendations aim to provide summarised information and practical implications to paediatricians and health professionals treating childhood cancer survivors to reduce the risk of cardiovascular late effects.Methods:The content derives from either published guidelines or expert opinions from Association of European Paediatric and Congenital Cardiology working groups and is in accordance with current state-of-the-art.Results:All usual methods of prevention and screening regarding the risk, monitoring, and treatment of occurring cardiovascular diseases are summarised. Additionally, modifiable lifestyle factors are explained, and clear practical implications are named.Conclusion:Modifiable lifestyle factors should definitely be considered as a cost-effective and complementary approach to already implemented follow-up care programs in cardio-oncology, which can be actively addressed by the survivors themselves. However, treating physicians are strongly encouraged to support survivors to develop and maintain a healthy lifestyle, including physical activity as one of the major influencing factors. This article summarises relevant background information and provides specific practical recommendations on how to advise survivors to increase their level of physical activity.
Assessing association of household diet diversity with mother’s time use on productive and reproductive activities: a case for gender sensitive social safety nets
Authors: Chaturvedi Surabhi , Swaminathan Sumathi , Makkar Sanchit , John Anjaly Teresa , Thomas Tinku 
Published: January 2024

Abstract

Objective:
In South Asia, while women make substantial economic contributions through their participation in agricultural sector, these contributions are undercounted as most of their work is underpaid or unpaid. This paper examines how mothers allocate their time to productive and reproductive activities and its association with a household’s ability to achieve high household diet diversity score.

Design:
The analysis uses data on household consumption and expenditure including food during the kharif (June to October) season (seeds are sown) and a modular time-use survey.

Setting:
Two districts of rural Bihar, India.

Participants:
Mothers with children less than 5 years of age and supported by the head of the household from 2026 households.

Results:
The estimates indicate that the high household diet diversity (High HDDS ≥ 10) is associated with greater time spent in reproductive activities by all women (OR = 1·12, 95 % CI: 1·06, 1·18). However, with increasing time spent in productive activities by the women the odds of achieving ‘High HDDS’ reduced (OR = 0·83, 95 % CI: 0·77, 0·89) in adjusted logistic regression analysis.

Conclusion:
The findings highlight propensity to achieve ‘High HDDS’ in Bihar increased with mothers allocating time towards reproductive activities, while it had an opposing effect with mothers allocating time on productive activities. Our study highlights that the policies that encourage women’s participation in agriculture or livestock should acknowledge the unpaid nature of some of the productive activities and design programs to improve economic agency of women to actuate the true potential of agriculture-nutrition pathways.
Modeling and management of cyber risk: a cross-disciplinary review
Authors: He Rong , Jin Zhuo , Li Johnny Siu-Hang 
Published: January 2024

AbstractThis paper provides a review of cyber risk research accomplished in different disciplines, with a primary goal to aid researchers in the field of insurance and actuarial science in identifying potential research gaps as well as leveraging useful models and techniques that have been considered in the literature. We highlight the recent advancements in cyber risk prediction, modeling, management, and insurance achieved in different domains including computer engineering, actuarial science, and business studies. The surveyed works are classified according to their respective modeling approaches, allowing readers to more easily compare the technical aspects of the surveyed works and spot out research gaps based on the research tools of their liking. We conclude this paper with a summary of possible research directions that are identified from the review.
Changing Climate Threatens Irrigation Benefits of Maize Gross Primary Productivity in China
Authors: Liao Dehai , Niu Jun , Ciais Philippe , Du Taisheng , Zhang Baozhong , Kang Shaozhong 
Published: January 2024

AbstractIntensive irrigation has been proven to profoundly impact climate through the surface energy budget. However, the impacts of irrigation and climate interactions on gross primary productivity (GPP) in maize cultivated areas remain uncertain. Here we quantified the irrigation effects on maize GPP (∆GPP) across China by combining a land surface model and a light‐use efficiency model and using satellite‐based irrigation water use. We show that irrigation significantly contributed to an increase in maize GPP by an average of 430 gC · m−2 · yr−1, equivalent to 28% of the irrigated maize GPP in China. These benefits (∆GPP) were attributed to irrigation effects (water supply, surface cooling) and climate interactions based on a machine learning framework (eXtreme Gradient Boosting model‐SHapley Additive exPlanations). Irrigation water supply and surface cooling explained 54% ± 19% and 23% ± 20% of ∆GPP respectively, the rest being due to strong climate interactions with irrigation through water and energy balance. Assuming business‐as‐usual irrigation levels, changing climate both increases and decreases ΔGPP over different regions, driven primarily by temperature changes. The irrigation benefits in those areas under heat stress are greatly threatened due to changing climate. The roles of climate change on ∆GPP are reversed from beneficial to detrimental in the North China Plain, dominated by different warming levels of future scenarios. Our analysis provides new insights into assessing irrigation potential with the climate interactions and future irrigation priority regions.
Hamiltonian Monte Carlo to Characterize Induced Earthquakes: Application to a ML 3.4 Event in the Groningen Gas Field and the Role of Prior
Authors: Masfara La Ode Marzujriban , Weemstra Cornelis 
Published: January 2024

AbstractThe Hamiltonian Monte Carlo algorithm is known to be highly efficient when sampling high‐dimensional model spaces due to Hamilton's equations guiding the sampling process. For weakly non‐linear problems, linearizing the forward problem enhances this efficiency. This study integrates this linearization with geological prior knowledge for optimal results. We test this approach to estimate the source parameters of a 3.4 magnitude induced event that originated in the Groningen gas field in 2019. The source parameters are the event's centroid (three components), its moment tensor (six components), and its origin time. In terms of prior knowledge, we tested two sets of centroid priors. The first set exploits the known fault geometry of the Groningen gas field, whereas the second set is generated by placing initial centroid priors on a uniform horizontal grid at a depth of 3 km (the approximate depth of the gas reservoir). As for the forward problem linearization, we use an approach in which the linearization is run iteratively in tandem with updates of the centroid prior. We demonstrate that, in the absence of a sufficiently accurate initial centroid prior, the linearization of the forward model necessitates multiple initial centroid priors. Eventually, both prior sets yield similar posteriors. Most importantly, however, they agree with the geological knowledge of the area: the posterior peaks for model vectors containing a centroid near a major fault and a moment tensor that corresponds to normal faulting along a plane with a strike almost aligning with that of the major fault.
Comment on “Five Decades of Observed Daily Precipitation Reveal Longer and More Variable Drought Events Across Much of the Western United States”
Authors: Paciorek C. J. , Wehner M. F. 
Published: January 2024

AbstractChanges in precipitation patterns with climate change could have important impacts on human and natural systems. Zhang et al. (2021, https://doi.org/10.1029/2020gl092293) report trends in daily precipitation patterns over the last five decades in the western United States, focusing on meteorological drought. They report that dry intervals (calculated at the annual or seasonal level) have increased across much of the southwestern U.S., with statistical assessment suggesting the results are statistically robust. However, Zhang et al. (2021, https://doi.org/10.1029/2020gl092293) preprocess their annual (or seasonal) averages to compute 5‐year moving window averages before using established statistical techniques for trend analysis that assume independence about some fixed trend. Here we show that the moving window preprocessing violates that independence assumption and inflates the statistical significance of their trend estimates. This raises questions about the robustness of their results. We conclude by discussing the difficulty of adjusting for spatial structure when assessing time trends in a regional context.
EBSD Analysis of Iron‐Nickel Metal in L Type Ordinary Chondrites: 1. The Microstructural Shock Signatures
Authors: Luo Yexin , Chen Hongyi , Beard Sky , Zeng Xiaojia , Hu Sen , Du Zhimao , Jin Lei , Liu Jiahui , Li Shaolin , Zhang Xiaoping 
Published: January 2024

AbstractThe diverse microstructures of Fe‐Ni metal in 10 L groups ordinary chondrites that experienced progressive shock alteration were investigated using the electron backscattered diffraction technique. Through a combination of metallography and a silicate‐based shock classification scheme, we established the shock metamorphic features of metal phases corresponding to particular impact stages. In weakly shocked chondrites (S1–S2), the interlaced Neumann bands occur in polycrystalline kamacite, resulting from multiple small impact events on its parent body, and the internal crystallographic orientation difference of each kamacite monocrystal exceeds 5°. In moderately shocked samples (S2–S4), partial austenitization of metal occurs, accompanied by the emergence of net plessite. In strongly shocked samples (S4–S6), the metal has undergone complete austenitization and transformed into a homogenous fcc phase. In subsequent different cooling processes, polycrystalline kamacite with consistent internal crystallographic orientation, martensite, pearlitic plessite, duplex plessite, and acicular plessite form and finally appear in L group chondrites. This study demonstrates the significant utility of the microstructure of metal phases as a valuable tool for both the shock classification of L chondrites and the determination of shock metamorphism stages in iron meteorites.
Patterns of Alluviation in Mixed Bedrock‐Alluvial Channels: 1. Numerical Model
Authors: Cho Jongseok , Nelson Peter A. 
Published: January 2024

AbstractMixed bedrock‐alluvial rivers can exhibit partial alluvial cover, which plays an important role in controlling bedrock erosion rates and landscape evolution. However, numerical morphodynamic models are generally unable to predict quasi‐steady persistent patches of depositional alluvial features under conditions where the sediment supply is less than the sediment transport capacity of the channel. Hence, we present a new two‐dimensional depth‐averaged morphodynamic model that can be applied to both fully alluvial and mixed bedrock‐alluvial channels, and we use the model to gain insight into the mechanisms responsible for the development of sediment patches and patterns of bedrock alluviation. The model computes hydrodynamics, sediment transport, and bed evolution using a roughness partitioning that accounts for differential roughness of sediment and bedrock, roughness due to sediment transport, and form drag. The model successfully replicates observations of bar development and migration from a fully alluvial flume experiment, and it models persistent sediment patches observed in a mixed bedrock‐alluvial flume experiment. Numerical experiments in which the form drag, sediment transport roughness, and bedform stress correction were neglected did not successfully reproduce the observed persistent sediment cover in the mixed bedrock‐alluvial case, suggesting that accounting for these different roughness components is critical to successfully model sediment dynamics in bedrock channels.
Vitamin D ameliorates age-induced nonalcoholic fatty liver disease by increasing the mitochondrial contact site and cristae organizing system (MICOS) 60 level
Authors: Kim Gyu Hee , Jeong Hyeon-Ju , Lee Yoo Jeong , Park Hyeon Young , Koo Soo Kyung , Lim Joo Hyun 
Published: January 2024

AbstractNonalcoholic fatty liver disease (NAFLD) is the most common liver disease. Despite intensive research, considerable information on NAFLD development remains elusive. In this study, we examined the effects of vitamin D on age-induced NAFLD, especially in connection with mitochondrial abnormalities. We observed the prevention of NAFLD in 22-month-old C57BL/6 mice fed a vitamin D3-supplemented (20,000 IU/kg) diet compared with mice fed a control (1000 IU/kg) diet. We evaluated whether vitamin D3 supplementation enhanced mitochondrial functions. We found that the level of mitochondrial contact site and cristae organizing system (MICOS) 60 (Mic60) level was reduced in aged mice, and this reduction was specifically restored by vitamin D3. In addition, depletion of Immt, the human gene encoding the Mic60 protein, induced changes in gene expression patterns that led to fat accumulation in both HepG2 and primary hepatocytes, and these alterations were effectively prevented by vitamin D3. In addition, silencing of the vitamin D receptor (VDR) decreased the Mic60 levels, which were recovered by vitamin D treatment. To assess whether VDR directly regulates Mic60 levels, we performed chromatin immunoprecipitation and reporter gene analysis. We discovered that VDR directly binds to the Immt 5’ promoter region spanning positions −3157 to −2323 and thereby upregulates Mic60. Our study provides the first demonstration that a reduction in Mic60 levels due to aging may be one of the mechanisms underlying the development of aging-associated NAFLD. In addition, vitamin D3 could positively regulate Mic60 expression, and this may be one of the important mechanisms by which vitamin D could ameliorate age-induced NAFLD.
Significance of chitinase-3-like protein 1 in the pathogenesis of inflammatory diseases and cancer
Authors: Yu Ji Eun , Yeo In Jun , Han Sang-Bae , Yun Jaesuk , Kim Bongcheol , Yong Yoon Ji , Lim Young-soo , Kim Tae Hun , Son Dong Ju , Hong Jin Tae 
Published: January 2024

AbstractChitinase-3-like protein 1 (CHI3L1) is a secreted glycoprotein that mediates inflammation, macrophage polarization, apoptosis, and carcinogenesis. The expression of CHI3L1 is strongly upregulated by various inflammatory and immunological diseases, including several cancers, Alzheimer’s disease, and atherosclerosis. Several studies have shown that CHI3L1 can be considered as a marker of disease diagnosis, prognosis, disease activity, and severity. In addition, the proinflammatory action of CHI3L1 may be mediated via responses to various proinflammatory cytokines, including tumor necrosis factor-α, interleukin-1β, interleukin-6, and interferon-γ. Therefore, CHI3L1 may contribute to a vast array of inflammatory diseases. However, its pathophysiological and pharmacological roles in the development of inflammatory diseases remain unclear. In this article, we review recent findings regarding the roles of CHI3L1 in the development of inflammatory diseases and suggest therapeutic approaches that target CHI3L1.
Multifaceted roles of CCAR family proteins in the DNA damage response and cancer
Authors: Lugano D. , Barrett L. , Westerheide S. D. , Kee Y. 
Published: January 2024

AbstractThe cell cycle apoptosis regulator (CCAR) family of proteins consists of two proteins, CCAR1 and CCAR2, that play a variety of roles in cellular physiology and pathology. These multidomain proteins are able to perform multiple interactions and functions, playing roles in processes such as stress responses, metabolism, and the DNA damage response. The evolutionary conservation of CCAR family proteins allows their study in model organisms such as Caenorhabditis elegans, where a role for CCAR in aging was revealed. This review particularly highlights the multifaceted roles of CCAR family proteins and their implications in the DNA damage response and in cancer biology.
Association of ACE1 I/D polymorphism and susceptibility to COVID-19 in Egyptian children and adolescents
Authors: Boraey Naglaa F. , Bebars Marwa A. , Wahba Ali A. , Abd El Lateef Hanan M. , Attia Mohamed Atif , Elsayed Ahmed H. , Rashed Khalid A. , Sorour Ehab I. , Ahmed Mohamed F. , Abd-Elrehim Ghada A. B. , Soliman Attia A. , Shehab Mohamed M. M. , Elhindawy Eman M. , Ibraheem Ahmed A. A. , Shehata Hassan , Yousif Yousif M. , Hashem Mustafa I. A. , Ahmed Amani A. , Emam Ahmed A. , Gameil Dalia M. , Abdelhady Eman M. , Abdelkhalek Khalil , Morsi Walaa E. M. A. , Selim Dalia M. , Razek Suzan A. , Ashraf Bassem , Saleh Ahmed S. E. , Eltrawy Heba H. , Alanwar Mohamed I. , Fouad Rania A. , Omar Walaa E. , Nabil Rehab M. , Abdelhamed Mohamed R. , Ibrahim Mona Yousri , Malek Mai M. , Afify Mona R. , Alharbi Mohanned T. , Nagshabandi Mohammed K. , Tarabulsi Muyassar K. , Qashqary Mohammed Esmail , Almoraie Laila M. , Salem Hanan F. , Rashad Manal M. , El-Gaaly Sonya A. A. , El- Deeb Nahawand A. , Abdallah Amany M. , Fakhreldin Ahmed R. , Hassouba Mohamed , Massoud Yasmine M. , Attaya Mona S. M. , Haridi Mohammed K. 
Published: January 2024

Abstract
Background
Given the sparse data on the renin-angiotensin system (RAS) and its biological effector molecules ACE1 and ACE2 in pediatric COVID-19 cases, we investigated whether the ACE1 insertion/deletion (I/D) polymorphism could be a genetic marker for susceptibility to COVID-19 in Egyptian children and adolescents.

Methods
This was a case-control study included four hundred sixty patients diagnosed with COVID-19, and 460 well-matched healthy control children and adolescents. The I/D polymorphism (rs1799752) in the ACE1 gene was genotyped by polymerase chain reaction (PCR), meanwhile the ACE serum concentrations were assessed by ELISA.

Results
The ACE1 D/D genotype and Deletion allele were significantly more represented in patients with COVID-19 compared to the control group (55% vs. 28%; OR = 2.4; [95% CI: 1.46–3.95]; for the DD genotype; P = 0.002) and (68% vs. 52.5%; OR: 1.93; [95% CI: 1.49–2.5] for the D allele; P = 0.032). The presence of ACE1 D/D genotype was an independent risk factor for severe COVID-19 among studied patients (adjusted OR: 2.6; [95% CI: 1.6–9.7]; P < 0.001.

Conclusions
The ACE1 insertion/deletion polymorphism may confer susceptibility to SARS-CoV-2 infection in Egyptian children and adolescents.

Impact

Recent studies suggested a crucial role of renin-angiotensin system and its biological effector molecules ACE1 and ACE2 in the pathogenesis and progression of COVID-19.

To our knowledge, ours is the first study to investigate the association of ACE1 I/D polymorphism and susceptibility to COVID-19 in Caucasian children and adolescents.

The presence of the ACE1 D/D genotype or ACE1 Deletion allele may confer susceptibility to SARS-CoV-2 infection and being associated with higher ACE serum levels; may constitute independent risk factors for severe COVID-19.

The ACE1 I/D genotyping help design further clinical trials reconsidering RAS-pathway antagonists to achieve more efficient targeted therapies.
LncRNA ZNF674-AS1 drives cell growth and inhibits cisplatin-induced pyroptosis via up-regulating CA9 in neuroblastoma
Authors: Zhao Kunming , Wang Xinyi , Jin Yaqiong , Zhu Xiaoxiao , Zhou Tao , Yu Yongbo , Ji Xiaoying , Chang Yan , Luo Jiao , Ni Xin , Guo Yongli , Yu Dianke 
Published: January 2024

Abstract
Neuroblastoma (NB) is a challenging pediatric extracranial solid tumor characterized by a poor prognosis and resistance to chemotherapy. Identifying targets to enhance chemotherapy sensitivity in NB is of utmost importance. Increasing evidence implicates long noncoding RNAs (lncRNAs) play important roles in cancer, but their functional roles remain largely unexplored. Here, we analyzed our RNA sequencing data and identified the upregulated lncRNA ZNF674-AS1 in chemotherapy non-responsive NB patients. Elevated ZNF674-AS1 expression is associated with poor prognosis and high-risk NB. Importantly, targeting ZNF674-AS1 expression in NB cells suppressed tumor growth in vivo. Further functional studies have revealed that ZNF674-AS1 constrains cisplatin sensitivity by suppressing pyroptosis and promoting cell proliferation. Moreover, ZNF674-AS1 primarily relies on CA9 to fulfill its functions on cisplatin resistance. High CA9 levels were associated with high-risk NB and predicted poor patient outcomes. Mechanistically, ZNF674-AS1 directly interacted with the RNA binding protein IGF2BP3 to enhance the stability of CA9 mRNA by binding with CA9 transcript, leading to elevated CA9 expression. As a novel regulator of CA9, IGF2BP3 positively upregulated CA9 expression. Together, these results expand our understanding of the cancer-associated function of lncRNAs, highlighting the ZNF674-AS1/IGF2BP3/CA9 axis as a constituting regulatory mode in NB tumor growth and cisplatin resistance. These insights reveal the pivotal role of ZNF674-AS1 inhibition in recovering cisplatin sensitivity, thus providing potential therapeutic targets for NB treatment.