bluuebunny/crossref_metadata_2025_split huggingface dataset:
Parental sex-dependent effects of either maternal or paternal eNOS deficiency on the offspring’s phenotype without transmission of the parental eNOS deficiency to the offspring
Authors: Zhang Xiaoli , Reichetzeder Christoph , Liu Yvonne , Hocher Johann-Georg , Hasan Ahmed A. , Lin Ge , Kleuser Burkhard , Hu Liang , Hocher Berthold 
Published: December 2023

Background: Preclinical animal studies and clinical studies indicate that both maternal as well as paternal genetic alterations/gene defects might affect the phenotype of the next-generation without transmissions of the affected gene. Currently, the question of whether the same genetic defect present in the mother or father leads to a similar phenotype in the offspring remains insufficiently elucidated.Methods: In this head-to-head study, we crossbred female and male mice with heterozygous endothelial eNOS knockout (eNOS+/−) with male and female wild-type (wt) mice, respectively. Subsequently, we compared the phenotype of the resulting wt offspring with that of wt offspring born to parents with no eNOS deficiency.Results: Wt female offspring of mothers with heterozygous eNOS showed elevated liver fat accumulation, while wt male offspring of fathers with heterozygous eNOS exhibited increased fasting insulin, heightened insulin levels after a glucose load, and elevated liver glycogen content. By quantitative mass-spectrometry it was shown that concentrations of six serum metabolites (lysoPhosphatidylcholine acyl C20:3, phosphatidylcholine diacyl C36:2, phosphatidylcholine diacyl C38:1, phosphatidylcholine acyl-alkyl C34:1, phosphatidylcholine acyl-alkyl C36:3, and phosphatidylcholine acyl-alkyl C42:5 (PC ae C42:5) as well as four liver carbon metabolites (fructose 6-phosphate, fructose 1,6-bisphosphate, glucose 6-phosphate and fumarate) were different between wt offspring with eNOS+/− mothers and wt offspring with eNOS+/− fathers. Importantly, fumarate was inversely correlated with the liver fat accumulation in female offspring with eNOS+/− mothers and increased liver glycogen in offspring of both sexes with eNOS+/− fathers. The qRT-PCR results revealed that the gene expression patterns were different between wt offspring with eNOS+/− mothers and those offspring with eNOS+/− fathers. Different gene expression patterns were correlated with different observed phenotypic changes in male/female offspring born to mothers or fathers with a heterozygous eNOS genotype.Conclusion: The identical parental genetic alteration (heterozygous eNOS deficiency), without being passed on to the offspring, results in distinct metabolic, liver phenotype, and gene expression pattern variations depending on whether the genetic alteration originated from the father or the mother.
Treatment effects of adjunct group music therapy in inpatients with chronic schizophrenia: a systematic review
Authors: Lam Lissa , Chang Wing Chung , Grimmer Karen 
Published: December 2023

IntroductionPharmacological treatment may be effective for treating positive symptoms of schizophrenia; no evidence of clinically significant effects on negative and cognitive symptoms, social and behavioral functioning. This review investigated treatment outcomes of multiple (at least four sessions in 4 weeks) group music therapy sessions adjunct to standard care in inpatients with chronic schizophrenia.MethodsA systematic review search of five electronic medical and psychological databases conducted using keywords “music therapy” and “schizophrenia” up to December 2021. Screening was performed for published articles on any adjunct multiple group music therapy (four sessions in 4 weeks minimum) adjunct to “treatment as usual” for inpatients with “chronic” schizophrenia. All study outcomes were all included. Risk of bias of all studies was assessed.Results1160 articles were screened, and 13 randomized controlled trials (RCTs) with a total of 1,114 inpatients were included. Ten RCTs reported open group sessions with active structured music making (ASMM) combining passive music listening (PML) and/or active singing, playing instruments, and improvisations while three other studies applied PML only. Four studies reported significant outcomes for both positive and negative symptoms. Ten of the thirteen studies recorded significant improvements in negative symptoms, behavioral and social functioning. Lasting significant effects were found in a longitudinal RCT with 272 samples evaluated unguided pre-recorded PML as a coping method lasting up to six months and similar results found in another two longitudinal RCTs. Secondary outcomes measured cognition, mood, social interest and function, self-care ability, interpersonal relationships, and QoL all showed significant outcomes. The significance level for pre-post intervention and between-group measures ranged from p &lt; 0.001 to p &lt; 0.05. No negative effects were reported in any studies.ConclusionEvidence from this review suggests rehabilitation with adjunctive regular PML or combined ASMM in group settings may provide therapeutic engagement, contributing to improvements in social interest and participation. PML is low-cost and non-invasive therapy. Enhancing overall QoL as one type of psychosocial therapy. More rigorous longitudinal studies with larger sample sizes are needed to investigate whether regular long-term individual PML and active group music therapy have the same significant treatment effects as coping and rehabilitation strategies.
Distinguishing functional and structural MRI abnormalities between bipolar and unipolar depression
Authors: Huang Shiqing , Wen Xiaoxia , Liu Zhiling , Li Cuiyun , He Yuqiu , Liang Jiaquan , Huang Wei 
Published: December 2023

BackgroundThis study aims to investigate the underlying characteristics of spontaneous brain activity by analyzing the volumes of the hippocampus and parahippocampal gyrus, as well as the fractional amplitude of low-frequency fluctuation (fALFF) and regional homogeneity (ReHo), in order to differentiate between bipolar disorder (BD) and unipolar depressive disorder.MethodsA total of 46 healthy controls, 58 patients with major depressive disorder (MDD), and 61 patients with BD participated in the study and underwent resting-state functional magnetic resonance imaging (rs-fMRI) scans. The researchers calculated the differences in volume, fALFF, and ReHo values among the three groups. Additionally, they conducted correlation analyses to examine the relationships between clinical variables and the aforementioned brain measures.ResultsThe results showed that the BD group exhibited increased fALFF in the hippocampus compared to the healthy control (HC) and MDD groups. Furthermore, the ReHo values in the hippocampus and parahippocampal gyrus were significantly higher in the BD group compared to the HC group. The findings from the person correlation analysis indicated a positive relationship between ReHo values in the hippocampus and both HAMD and HAMA scores. Moreover, there was no correlation between the volumes, fALFF, and ReHo values in the hippocampus and parahippocampal gyrus, and cognitive function levels (RBANS).ConclusionTaken together, these aberrant patterns of intrinsic brain activity in the hippocampus and parahippocampal gyrus may serve as quantitative indicators for distinguishing between BD and unipolar depression.
A health economic analysis of an integrated diabetes care program in China: based on real-world evidence
Authors: Liang Di , Zhu Wenjun , Huang Jiayan , Dong Yin 
Published: December 2023

IntroductionAn integrated care program was set up in China to improve the collaboration between primary healthcare centers and hospitals on diabetes management. This study aims to evaluate the economic value of this program with real-world data and to examine whether it can be promoted in primary healthcare settings in China.MethodsThis integrated diabetes care program was implemented in Yuhuan City, China, to coordinate primary care and specialty care, treatment and prevention services, as well as the responsibilities of doctors and nurses. Cost-effectiveness analysis was used to compare the short-term economic value of this program (intervention group) versus usual diabetes management (control group). The cost data were collected from a societal perspective, while the effectiveness indicators pointed to the improvement of control rates of fasting blood glucose (FBG), systolic blood pressure (SBP), and diastolic blood pressure (DBP) levels after the 1 year intervention. In addition, cost-utility analysis was applied to evaluate the long-term value of the two groups. Patients’ long-term diabetes management costs and quality-adjusted life years (QALYs) were simulated by the United Kingdom Prospective Diabetes Study Outcomes Model 2.ResultsThe results showed that for 1% FBG, SPB, and DBP control rate improvement, the costs for the intervention group were 290.53, 124.39, and 249.15 Chinese Yuan (CNY), respectively, while the corresponding costs for the control group were 655.19, 610.43, and 1460.25 CNY. Thus, the intervention group’s cost-effectiveness ratios were lower than those of the control group. In addition, compared to the control group, the intervention group’s incremental costs per QALY improvement were 102.67 thousand CNY, which means that the intervention was cost-effective according to the World Health Organization’s standards.DiscussionIn conclusion, this study suggested that this integrated diabetes care program created short-term and long-term economic values through patient self-management support, primary care strengthening, and care coordination. As this program followed the principles of integrated care reform, it can be promoted in China. Also, its elements can provide valuable experience for other researchers to build customized integrated care models.
Heart rate variability status at rest in adult depressed patients: a systematic review and meta-analysis
Authors: Wu Qianqian , Miao Xiangyang , Cao Yingying , Chi Aiping , Xiao Tao 
Published: December 2023

PurposesA meta-analysis was conducted to examine the differences in heart rate variability (HRV) between depressed patients and healthy individuals, with the purpose of providing a theoretical basis for the diagnosis of depression and the prevention of cardiovascular diseases.MethodsTo search China National Knowledge Infrastructure (CNKI), WanFang, VIP, PubMed, Web of Science, Science Direct, and Cochrane Library databases to collect case–control studies on HRV in depressed patients, the retrieval date is from the establishment of the database to December 2022. Effective Public Health Practice Project (EPHPP) scale was used to evaluate literature quality, and Stata14.0 software was used for meta-analysis.ResultsThis study comprised of 43 papers, 22 written in Chinese and 21 in English, that included 2,359 subjects in the depression group and 3,547 in the healthy control group. Meta-analysis results showed that compared with the healthy control group, patients with depression had lower SDNN [Hedges’ g = −0.87, 95% CI (−1.14, −0.60), Z = −6.254, p &lt; 0.01], RMSSD [Hedges’ g = −0.51, 95% CI (−0.69,-0.33), Z = −5.525, p &lt; 0.01], PNN50 [Hedges’ g = −0.43, 95% CI (−0.59, −0.27), Z = −5.245, p &lt; 0.01], LF [Hedges’ g = −0.34, 95% CI (−0.55, − 0.13), Z = −3.104, p &lt; 0.01], and HF [Hedges’ g = −0.51, 95% CI (−0.69, −0.33), Z = −5.669 p &lt; 0.01], and LF/HF [Hedges’ g = −0.05, 95% CI (−0.27, 0.18), Z = −0.410, p = 0.682] showed no significant difference.ConclusionThis research revealed that HRV measures of depressed individuals were lower than those of the healthy population, except for LF/HF, suggesting that people with depression may be more at risk of cardiovascular diseases than the healthy population.
Association of quantitative radiomic shape features with functional outcome after surgery for primary sporadic dorsal spinal meningiomas
Authors: Vychopen Martin , Arlt Felix , Wilhelmy Florian , Seidel Clemens , Barrantes-Freer Alonso , Güresir Erdem , Wach Johannes 
Published: December 2023

ObjectiveSpinal meningiomas (SM) account for 25%–46% of all primary spinal tumors and show an excellent long-term disease control in case of complete resection. Therefore, the postoperative functional outcome is of high importance. To date, reports on dorsally located SM are scarce. Moreover, the impact of radiomics shape features on the functional outcome after surgery for primary dorsal SMs has not been analyzed yet.MethodsWe retrospectively performed an analysis of shape-based radiomic features in 3D slicer software and quantified the tumor volume, surface area, sphericity, surface area to volume ratio and tumor canal ratio. Subsequently, we evaluated the correlation between the radinomic parameters and the postoperative outcome according to Modified Japanese Orthopedic Association (mJOA) score.ResultsBetween 2010 and 2022, we identified 24 Females and 2 Males operated on dorsal SMs in our institutional database. The most common SM localization was thoracic spine (n = 20), followed by cervical (n = 4), and lumbar (n = 2). The univariate analysis and the receiver operating characteristic (ROC) analysis showed a strong diagnostic performance of sphericity in the prediction of postoperative functional outcome based on mJOA score (AUC of 0.79, sphericity cut-of value 0.738; p = 0.01). Subsequently, the patients were divided into two groups (mJOA improved vs. mJOA stable/worsened). Patients with improved mJOA score showed significantly higher sphericity (0.79 ± 0.1 vs. 0.70 ± 1.0; p = 0.03). Finally, we divided the cohort based on sphericity (&lt;0.738 and ≥0.738). The group with higher sphericity exhibited a significantly higher positive mJOA difference 3 months postoperatively (16.6 ± 1.4 vs. 14.8 ± 3.7; p = 0.03).ConclusionIn our study investigating primary sporadic dorsal SMs, we demonstrated that a higher degree of sphericity may be a positive predictor of postoperative improvement, as indicated by the mJOA score.
Development and internal validation of diagnostic prediction models using machine-learning algorithms in dogs with hypothyroidism
Authors: Corsini Andrea , Lunetta Francesco , Alboni Fabrizio , Drudi Ignazio , Faroni Eugenio , Fracassi Federico 
Published: December 2023

IntroductionHypothyroidism can be easily misdiagnosed in dogs, and prediction models can support clinical decision-making, avoiding unnecessary testing and treatment. The aim of this study is to develop and internally validate diagnostic prediction models for hypothyroidism in dogs by applying machine-learning algorithms.MethodsA single-institutional cross-sectional study was designed searching the electronic database of a Veterinary Teaching Hospital for dogs tested for hypothyroidism. Hypothyroidism was diagnosed based on suggestive clinical signs and thyroid function tests. Dogs were excluded if medical records were incomplete or a definitive diagnosis was lacking. Predictors identified after data processing were dermatological signs, alopecia, lethargy, hematocrit, serum concentrations of cholesterol, creatinine, total thyroxine (tT4), and thyrotropin (cTSH). Four models were created by combining clinical signs and clinicopathological variables expressed as quantitative (models 1 and 2) and qualitative variables (models 3 and 4). Models 2 and 4 included tT4 and cTSH, models 1 and 3 did not. Six different algorithms were applied to each model. Internal validation was performed using a 10-fold cross-validation. Apparent performance was evaluated by calculating the area under the receiver operating characteristic curve (AUROC).ResultsEighty-two hypothyroid and 233 euthyroid client-owned dogs were included. The best performing algorithms were naive Bayes in model 1 (AUROC = 0.85; 95% confidence interval [CI] = 0.83–0.86) and in model 2 (AUROC = 0.98; 95% CI = 0.97–0.99), logistic regression in model 3 (AUROC = 0.88; 95% CI = 0.86–0.89), and random forest in model 4 (AUROC = 0.99; 95% CI = 0.98–0.99). Positive predictive value was 0.76, 0.84, 0.93, and 0.97 in model 1, 2, 3, and 4, respectively. Negative predictive value was 0.89, 0.89, 0.99, and 0.99 in model 1, 2, 3, and 4, respectively.DiscussionMachine learning-based prediction models were accurate in predicting and quantifying the likelihood of hypothyroidism in dogs based on internal validation performed in a single-institution, but external validation is required to support the clinical applicability of these models.
Estudo da prevalência do toro mandibular e palatino e sua associação com hábitos parafuncionais
Authors: Arioso Letícia Sant’ana , Carvalho Wagner José Sousa , Neuber Julia Dora Niem , Cardoso Camila Lopes 
Published: December 2023

O toro mandibular e palatino são exostoses de caráter benigno, não neoplásico, assintomáticos e não requerem nenhuma forma de tratamento. Estudos de prevalência e investigação sobre sua etiologia ainda permanecem controversos. Avaliar a prevalência do toro mandibular e palatino e sua relação com a presença de hábitos parafuncionais e problemas sistêmicos. Estudo retrospectivo, utilizando como fonte de dados prontuários de pacientes que foram atendidos na Clínica de Estomatologia de um Curso de Odontologia nos últimos dez anos. Do total de 1024 prontuários avaliados, foram incluídos somente 39 prontuários (3,8%). Nenhum paciente apresentou história de hábito parafuncional, bruxismo ou apertamento. Considerando o gênero, os resultados revelaram 23 mulheres (58,9%) e 16 homens (41,1%). A média de idade da população estudada foi 45,7. Com relação a presença de problemas sistêmicos, 16 (41,1%) pacientes apresentaram algum tipo de doença sistêmica e 23 (58,9%) não. Através deste estudo pode ser concluído que embora a amostra seja restrita, não houve associação de toro com hábitos parafuncionais.
Keterlibatan Klerikus Dalam Politik: Tinjauan Hukum Gereja Dan Kesaksian Hidup San Giovanni Xxiii
Authors: Tjatur Raharso Alphonsus Tjatur Raharso 
Published: December 2023

This research raises the theme of clerical involvement in politics, which still creates pro and con reactions. The questions answered in this research are what, how, and to what extent clerics may engage or are prohibited from engaging in politics. What are the reasons and purposes of the Catholic Church in prohibiting its clergy from engaging in politics? What are the legal consequences for the clerics involved in practical politics? Is there any good example for clerics in engaging in politics? This research uses the normative research method of Church law. The problem is approached using the deductive method, by departing from the legal norms of the Church which are elaborated using documents issued by the Holy See. The research also uses the inductive method through a study on the testimonies of the life of St. John XXIII. The deductive and inductive approaches are combined to find the scope of meaning and the proper and wise application of the ecclesiastical norm regarding clerical involvement in politics. The study found that the clerical mission cannot be separated from politics. The call to configure oneself fully to the person and mission of Christ requires clerics to take the side of the small, the poor, the oppressed, and the marginalized by conducting sharp socio-political criticism agaist unfair, unequal and discriminatory government or economic systems. The teaching of clerics should have a political impact on the lives of the faithful, especially the laity, to the point of encouraging them to become fully involved in practical politics to fight for justice, truth, peace and the common good with other members of society. However, concern for the political problems of the nation must never lead clerics to become directly and actively involved through political parties. Such involvement will divide the communion of the people, will mix politics and religion, and will run the risk of creating hostility both within the Church itself and outside the Church. Violation of the prohibition to actively participate in political parties results in the suspension of the cleric concerned. As the life witnessed by St. John XXIII, clerics are to be fathers of all people, persons of dialogue and peace, above all parties and for all parties. Clerics represent the Church that does not bind itself to any particular political system, and remains present and works in whatever political system, which is democratically selected and established by all citizens
Minoritas dan Politik Indonesia dari Sudut Pandang HAM
Authors: Go Twan An Petrus 
Published: December 2023

Tema “Minoritas dan Politik” tak hanya real-aktual di pelbagai Negara, terutama di mana maioritas & minoritas berdampingan seperti Indonesia, melainkan juga menyangkut banyak orang kelompok mi-noritas yang terkena “nasib” minoritas. Sudut pandang HAM bukan hanya metode, melainkan juga menyangkut dan mempengaruhi isi/kenyataan. Keadaan dewasa ini tak final, melainkan dalam proses pengembangan, juga dalam praktek HAM yang sudah diwujudkan dengan cukup baik, sudut pandang pembahasan tema ini tetap rasional, jembatan titik temu aneka kelompok maioritas-minoritas. Dalam cahaya HAM perbedaan tajam maioritas-minoritas mengalami relativisasi, karena dengan upaya me-madamkan SARA (Suku, agama, ras, antargolongan) Indonesia berusaha mengatasinya dengan me-nyerukan kesetaraan dan persaudaraan bagi semua WNI.
Editorial - Fênix v. 20 n. 2 (20): Dossiê: Cultura em Direitos Humanos e Educação - Julho - Dezembro 2023
Authors: RAMOS Freire Alcides , PATRIOTA Rosangela , SILVA Pereira Robson 
Published: December 2023

É com imensa satisfação que lançamos mais um número do periódico científico Fênix – Revista de História e Estudos Culturais (Volume 20, Ano XX, Número 2 – Julho – Dezembro 2023). Neste número, temos a enorme satisfação de publicar QUINZE (15) artigos na Seção Livre, bem como ONZE (11) no Dossiê “Cultura em Direitos Humanos e Educação” (organizado por João Clemente de Souza Neto e Celso Luiz Prudente), totalizando VINTE E SEIS (26) artigos. Como de hábito, esse conjunto caracteriza-se pela multiplicidade/diversidade de pontos de vista, mas sempre em sintonia com as temáticas que dão identidade ao periódico Fênix – Revista de História e Estudos Culturais.
Por fim, mas não menos importante, a seção reservada às RESENHAS presenteia o leitor com TRÊS (03) sugestões bibliográficas. De fato, merecem ser vistas, mais de perto, as avaliações críticas de Fernando Santos da Silva, Julio Cesar Aquino Teles Ferriera e Maurício Biscaia Veiga.
Analisis Faktor Penyebab Pengembalian Berkas Klaim BPJS Kesehatan Pasien Rawat Inap Di RSUD Tabanan
Authors: Kanaya I Gusti Ayu Kade Yuli , Putra Gede Wirabuana , Putri Putu Chrisdayanti Suada , Pradnyani Putu Erma , Adiningsih Luh Yulia , Vergantana I Wayan Septa Malan 
Published: December 2023

Return of claim files is one of the requirements for claim files that are declared incomplete by the BPJS. The results of initial observations in October - December 2022 showed that 2,833 claim files were submitted and 165 files were not accepted so they were returned. This study aims to determine the relationship between membership administration factors, service administration factors and health service administration factors on the return of BPJS Health claims. The research design used in this research is quantitative with a cross sectional research type. Methods of data collection by observation and checklist. The sample in this study was 96 BPJS claim files for inpatients in October 2022 – April 2023. The research results obtained were from 65 claims that were not returned and 31 were returned, showing a relationship between membership administration factors, service administration factors and health service administration factors on the return of BPJS Health claims with a p value = 0.0001. The conclusion from this study is that the membership administration, service and health care factors greatly influence the return of BPJS Health claims for inpatients. The advice given is that it is hoped that officers will pay more attention to the suitability of BPJS health claims so that they can improve the quality of the hospital.

Keyword : File Return, BPJS Claims