bluuebunny/crossref_metadata_2025_split huggingface dataset:
Understanding fishing and conservation of the Pacific seahorse (Hippocampus ingens) in Sinaloa, Mexico, through local ecological knowledge
Authors: Najera‐Medellin Jesus Alejandro , Quiñónez‐Martínez Miroslava , Narchi Nemer E. , Santos‐Fita Dídac , Díaz‐Gaxiola Jesús Manuel 
Published: December 2023

Abstract

The Pacific seahorse (Hippocampus ingens) is a teleost fish native to the Pacific Ocean. In Mexico they are protected by national legislation; however, there are no studies regarding their commercial use or population status. From a conservation perspective they are a threatened fish and from a socio‐economic aspect they represent a source of income for many fishing communities. The integration of these two points of view requires, among other things, the recognition that fishers have knowledge and skills that can help implement conservation strategies and management plans for seahorses and their habitats.
The objective was to document the knowledge of fishers from Sinaloa about the fishing status and current commercialization of wild populations of H. ingens. For this, semi‐structured interviews and participatory observation were carried out with 112 participants in the two main ports of the state of Sinaloa (Mazatlán and Topolobampo) from July to August 2021. The data obtained were coded and then, through content analysis, systematized results were obtained that allowed a qualitative and quantitative analysis.
The species was found to be caught using six different fishing gears (catch per unit effort, CPUE = 0.07–1.24 seahorses per boat per day) and have an important financial value. Most fishers catch seahorses incidentally, but three of them mentioned targeting them directly. Fishers perceive a decrease in catches and in the size of the Pacific seahorse, as well as an increase in prices.
The information analysed indicates that seahorse populations in Sinaloa are exploited and have economic value, despite current regulations. This study shows that the exploitation of seahorses in Sinaloa is unsustainable and requires the implemention of collaborative management strategies (e.g. stakeholder management, the establishment of marine protected areas, sustainable harvest practices, community‐based enforcement efforts, educational campaigns, research, and conservation partnerships) that fully take into account the knowledge and practice of local fishers of Sinaloa and Mexico.
Declining Incidence of Systemic Lupus Erythematosus in Norway 1999–2017: Data From a Population Cohort Identified by International Classification of Diseases, 10th Revision Code and Verified by Classification
Authors: Haukeland Hilde , Moe Sigrid R. , Brunborg Cathrine , Botea Antonela , Damjanic Nenad , Wivestad Gro Å. , Øvreås Heidi K. , Bøe Thea B. , Orre Anniken , Garen Torhild , Molberg Øyvind , Lerang Karoline 
Published: December 2023

ObjectiveThe goal of this study was to provide complete, robust data on annual systemic lupus erythematosus (SLE) incidence rates over nearly two decades from the Southeast Norway area (2.9 million inhabitants) and assess accuracy of SLE‐specific International Classification of Diseases (ICD) codes for SLE diagnosis.MethodsFrom administrative databases, we identified all cases International Statistical Classification of Diseases and Related Health Problems, Tenth Revision (ICD‐10) coded as SLE during 1999 through 2017 in Southeast Norway. We manually reviewed the chart of every case ICD‐10 coded as SLE to either confirm or reject SLE diagnosis. Using SLE classification criteria, we classified all cases with confirmed SLE. We estimated annual incidence rates of classified SLE, and subsets, defined by age at diagnosis, sex, and parental country of birth. The chi‐square test was applied for linear time‐trend analyses of incidence.ResultsAmong the 3,488 cases ICD‐10 coded as SLE, chart reviews confirmed SLE diagnosis in 1,558 (45%), of which 797 had new‐onset disease during 1999 through 2017. Annual SLE incidence rates fell during 1999 to 2017. The fall was most pronounced in female persons 50 to 59 years old at diagnosis, in whom incidence fell from 3.4 to 1.1 per 100,000 persons (P trend < 0.001). Concurrent ecological data from the study area showed a 74% reduction in prescriptions of menopausal hormone treatment. Accuracy of ICD‐10 codes for incident SLE diagnosis was acceptable in juveniles and young adults (up to 20 years) but otherwise low.ConclusionIn a presumably complete population‐based cohort, we identified decreasing incidence of SLE, especially among female persons 50 to 59 years old. Although reasons for declining incidence are not clear, ecological data indicate a possible role of environmental factors, for example, menopausal hormone treatments.image
Amorphous Ni(OH)2‐Ni3S2/NF nano‐flower heterostructure catalyst promotes efficient urea assisted overall water splitting
Authors: Zhou Lixue , Feng Daming , Liu Chang , Sun Ying , Fu Yang , Ma Tianyi 
Published: December 2023

AbstractUrea assisted overall water splitting represents a cost‐effective and efficient technology for hydrogen production, which not only obviates the generation of explosive H2 and O2 gas mixture but also minimizes the energy cost for the water splitting. In this study, we employed a one‐pot hydrothermal method to directly synthesize Ni(OH)2‐Ni3S2/NF hybrid nanoflowers on a nickel foam (NF) substrate, resulting in efficient and stable bi‐functional electrocatalysts for urea oxidation reaction (UOR) and hydrogen evolution reaction (HER). Under alkaline conditions, the Ni(OH)2‐Ni3S2/NF catalyst exhibits low voltage requirements of 1.346 V and −0.014 V vs. RHE with a current density of 10 mA cm−2 for UOR and HER, respectively. Furthermore, when employing the Ni(OH)2‐Ni3S2/NF catalyst as both anode and cathode for urea‐assisted overall water splitting, it requires a cell voltage of merely 1.396 V with a current density of 10 mA cm−2, which is notably lower than the voltage required for complete water decomposition at the same current density (1.568 V vs. RHE). The one‐step synthesis of the Ni(OH)2‐Ni3S2/NF catalyst lays a foundation for further exploration of other transition metal complexes as dual‐function electrocatalysts, enabling energy‐efficient electrolytic hydrogen production and the treatment of urea‐rich wastewater.
Increased anticholinergic medication use in middle‐aged and older autistic adults and its associations with self‐reported memory difficulties and cognitive decline
Authors: McQuaid Goldie A. , Duane Sean C. , Ahmed Neha , Lee Nancy Raitano , Charlton Rebecca , Wallace Gregory L. 
Published: December 2023

AbstractMany commonly used prescription and over‐the‐counter medicines have potent anticholinergic (AC) effects. Among older adults, AC medications are associated with cognitive impairment and risk for cognitive disorders, including Alzheimer's disease. Collectively, the impact of AC medications is known as anticholinergic cognitive burden (ACB). Because of the high rates of co‐occurring medical and psychiatric conditions, autistic adults may have high AC exposure and, thus, may experience elevated ACB. However, no research has characterized AC exposure or examined its associations with cognitive outcomes in autistic adults. Autistic adults (40–83 years) recruited via Simons Powering Autism Research's (SPARK) Research Match service self‐reported their medication use (N = 415) and memory complaints (N = 382) at Time (T)1. At T2, 2 years later, a subset of T1 participants (N = 197) self‐reported on decline in cognition. Medications were coded using two scales of AC potency. A high proportion (48.2%–62.9%, depending upon the AC potency scale) of autistic adults reported taking at least one medication with AC effects, and 20.5% to 26.5% of autistic adults reported clinically‐relevant levels of AC medication (potency ≥3). After controlling for birth‐sex, and age, hierarchical linear regression models showed total ACB scores and AC potency values of ≥3 predicted greater memory complaints. Logistic regression models showed that AC medicines at T1 were associated with self‐reported cognitive decline at follow‐up 2 years later. Understanding AC medications—including potentially earlier AC polypharmacy—and their impacts on cognition (e.g., dementia risk) in autistic adults is warranted.
Life‐cycle analysis of sustainable aviation fuel production through catalytic hydrothermolysis
Authors: Chen Peter Hua , Lee Uisung , Liu Xinyu , Cai Hao , Wang Michael 
Published: December 2023

AbstractCatalytic hydrothermolysis (CH) is a sustainable aviation fuel (SAF) pathway that has been recently approved for use in aircraft fuel production. In alignment with broader sustainable aviation goals, SAF production through CH requires a quantitative assessment of carbon intensity (CI) impacts. In this study, a current‐day life‐cycle analysis (LCA) was performed on SAF produced via CH to determine the CI. Various oily feedstocks were considered, including vegetable oils (soybean, carinata, camelina and canola) and low‐burden oils and greases (corn oil, yellow grease and brown grease). Life‐cycle inventory data were collected on all processes within the CH LCA boundary: feedstock cultivation and/or collection, preprocessing, hydrothermal cleanup and CH, biocrude refining, fuel transportation and end use through combustion. Baseline results show that the CH‐produced SAF can be generated with CI reductions ranging from 48 to 82% compared with conventional jet fuel. Modest improvements to CI can be achieved through incremental changes to the brown grease CH process, such as relaxing the dewatering specification and implementing renewable natural gas and electricity, which could decrease the CI from 22.9 to 7.9 g CO2e/MJ. Total CH fuel production potential was also assessed on the basis of current or near‐future feedstock availability and CI. The total biofuel production potential of CH (SAF and renewable fuel co‐products) in the US sums to approximately 3487 million gallons per year, with 97% of these volumes having a CI below 50% of that for petroleum jet fuel. The study shows that from an LCA perspective, CH offers a viable SAF pathway that is comparable with existing SAF pathways like hydroprocessed esters and fatty acids.
Anti‐inflammatory activity of a new lactone isolated from the leaves of Ardisia crenata Sims
Authors: Tao Hui‐Hui , Zhou Yong‐Qiang , Wei Xin , Yin Xin , Zhao Chunli , Zhou Ying 
Published: December 2023

AbstractOne new lactone (1) named Ardisicreolide C, together with three saponin compounds, Ardisiacrispin B (2), Ardisicrenoside A (3), Ardisiacrispin A (4) were isolated and identified from the leaves of Ardisia crenata Sims. The structures of 1–4 were elucidated by 1D, 2D‐NMR and HR‐MS spectra and together with the published data. In view of structures with lactone moieties showed good anti‐inflammatory activity, the anti‐inflammatory effects of Ardisicreolide C on LPS‐induced RAW264.7 cells were evaluated by enzyme linked immunosorbent assay (ELISA) method. As a result, Ardisicreolide C could reduce release of nitric oxide (NO), tumour necrosis factor α (TNF‐α), interleukin 1β (IL‐1β), interleukin 4 (IL‐4) and interleukin 10 (IL‐10) of the cell supernatant to exert anti‐inflammatory activity. This indicates that the leaves as non‐medicinal parts of Ardisia crenata Sims contain compounds with good anti‐inflammatory activity, which provides a new direction for the discovery of anti‐inflammatory drugs.
Predictionof Environmental FateandToxicityofInsecticidesUsing Multi‐Target QSAR Approach
Authors: Pandey Vandana 
Published: December 2023

AbstractEcotoxicological risk assessments form the foundation of regulatory decisions for industrial chemicals used in various sectors. In this study, a multi‐target‐QSAR model established by a backpropagation neural network trained with the Levenberg‐Marquardt (LM) algorithm was used to construct a statistically robust and easily interpretable Mt‐QSAR model with high external predictability for the simultaneous prediction of the environmental fate in form of octanol‐water partition coefficient (LogP), (BCF) and acute oral toxicity in mammals and birds (LD50rat) and (LD50bird) for a wide range of chemical structural classes of insecticides. Principal component analysis was performed on descriptors selected by the SW‐MLR method, and the selected PCs were used for constructing the SW‐MLR‐PCA‐ANN model. The developed well‐trained model (RMSE=0.83, MPE=0.004, CCC=0.82, IIC=0.78, R2=0.69) was statistically robust as indicated by the external validation parameters (RMSE=0.93, MPE=0.008, CCC=0.77, IIC=0.68, R2=0.61). The AD of the developed Mt‐QSAR model was also defined to identify the most reliable predictions. Finally, the missing values in the dataset for the aforementioned targets were predicted using the constructed Mt‐QSAR model. The proposed approach can be used for simultaneous prediction of the environmental fate of new insecticides, especially ones that haven′t been tested yet.
An in silico approach to investigate the theranostic potential of coumarin‐derived self‐immolative luminescent probes
Authors: Venkatesan Swathi , Chanda Kaushik , Balamurali M. M. 
Published: December 2023

AbstractTill date the challenge exists in the treatments of cancer for various reasons. Most importantly, the available diagnostics are expensive with research gap for enhancing the cancer detection sensitivity. Herein, a series of coumarin‐derived fluorescent theranostic probes are reported that can serve as potent anticancer agents as well as in the detection of cancer cells. The potential of these probes to efficiently block one of the well‐known cancer drug targets NADPH quinone oxidoreductase‐1 (NQO1) is evaluated through various pharmacokinetic methods including absorption, distribution, metabolism and excretion (ADME) properties evaluation, PASS (prediction of activity spectra for substance) algorithm along with molecular docking and dynamic simulations. Further the luminescent properties of these molecules were evaluated by investigating their electronic properties in the ground and excited states with the help of density functional theory methods. Results indicate that the proposed molecules can potentially block the NADPH (reduced form of nicotinamide adenine dinucleotide) binding site of NQO1, thereby inhibiting the activity of the enzyme to ultimately disrupt the metabolism of cancer cells.
Naringenin, Hesperidin and Quercetin Ameliorate Radiation‐Induced Damage In Rats: In Vivo And In Silico Evaluations
Authors: Uguz Handan , Avcı Bahri , Palabıyık Esra , Nurseli Sulumer Ayşe , Kızıltunç Özmen Hilal , Demir Yeliz , Aşkın Hakan 
Published: December 2023

AbstractIn this study, we sought to determine how well naringenin, hesperidin, and quercetin prevented damage brought on by radiotherapy. During the investigation, 48 adult female Sprague Dawley rats were used. Eight groups of eight rats each were formed by randomly assigning the rats to the groups. The normal control group was represented by Group 1. Group 2 rats were those that received a dose of 15 Gray (Gy) of radiotherapy. The rats assigned to Group 3 received only Naringenin, whereas those assigned to Group 4 received only quercetine, and those assigned to Group 5 received only hesperidin. Rats in Group 6, 7 and 8 were received naringenin, quarcetin and hesperidin at a dose of 50 mg/kg daily for one week prior to radiotheraphy exposition. After radiotheraphy and phenolic compounds rats were sacrificed and some metabolic enzyme (aldose reductase (AR), sorbitol dehydrogenase (SDH), paraoxonase‐1 (PON1), butyrylcholinesterase (BChE) and glutathione S‐transferase (GST)) activity was determined in eye and brain tissues. It was found that phenolic compounds have protective effect against radiation‐induced damage because of their anti‐diabetic antioxidant and anti‐inflammatory properties. In addition, hesperidin was found to be superior to quercetin and naringenin in terms of enzyme activity efficacy. Furthermore, hesperidin exhibited favorable binding affinity for BChE in silico compared to other enzymes.
Methanol Dehydration to Dimethyl Ether on Ball Milling‐Derived High‐Surface‐Area Alpha‐Alumina Catalysts
Authors: Agbaba Özgül , Amrute Amol P. , Ochoa‐Hernandez Cristina , Triller Sarah , Schüth Ferdi 
Published: December 2023

AbstractAlpha alumina (α‐Al2O3) catalysts synthesized by ball milling are investigated in the dehydration of methanol to dimethyl ether (DME). The activity and stability of the catalysts were studied in a fixed‐bed continuous‐flow reactor setup. The effect of water vapor in the feed was studied as well. Among different alumina polymorphs studied, γ‐ alumina has been known to be the most effective for this reaction; however, the high surface area α‐Al2O3, which had been synthesized by ball milling, resulted in a comparable rate of methanol conversion, while it revealed a more stable performance under the influence of water vapor. The surface area, the number, and the nature of the acidic sites were found to be relevant parameters for the conversion of methanol to DME. The selectivity was as high as 99 % towards DME.
Ethynyl‐B(dan) in [3+2] Cycloaddition and Larock Indole Synthesis: Synthesis of Stable Boron‐Containing Heteroaromatic Compounds
Authors: Li Jialun , Tanaka Hideya , Imagawa Taiki , Tsushima Takumi , Nakamoto Masaaki , Tan Jiajing , Yoshida Hiroto 
Published: December 2023

AbstractThe cycloaddition of nitrile oxides with ethynyl‐B(dan) (dan=naphthalene‐1,8‐diaminato) allowed the facile preparation of diverse isoxazolyl‐B(dan) compounds, all of which displayed excellent protodeborylation‐resistant properties. The dan‐installation on the boron center proves vital to the high stability of the products as well as the perfect regioselectivity arising from hydrogen bond‐directed orientation in the cycloaddition. The diminished boron‐Lewis acidity of ethynyl‐B(dan) also renders it amenable to azide‐alkyne cycloaddition, Larock indole synthesis and related heteroannulations. The obtained boron‐containing triazole, indoles, benzofuran and indenone exhibit sufficient resistance toward protodeborylation. Despite the commonly accepted transmetalation‐inactive property derived from the diminished Lewis acidity, the synthesized heteroaryl‐B(dan) compound was still found to be convertible to the oligoarene via sequential Suzuki‐Miyaura coupling.
Mono(Lewis Base)‐Stabilized Gallium Iodide: An Unexplored Class of Promising Ligands
Authors: Ahmed Sahtaz , Das Himashri , González‐Pinardo Daniel , Fernández Israel , Phukan Ashwini K. 
Published: December 2023

AbstractQuantum‐chemical (DFT) calculations on hitherto unknown base(carbene)‐stabilized gallium monoiodides (LB→GaI) suggest that these systems feature one lone pair of electrons and a formally vacant p‐orbital – both centered at the central gallium atom – and exhibit metallomimetic behavior. The calculated reaction free energies as well as bond dissociation energies suggest that these LB→GaI systems are capable of forming stable donor‐acceptor complexes with group 13 trichlorides. Examination of the ligand exchange reactions with iron and nickel complexes indicates their potential use as ligands in transition metal chemistry. In addition, it is found that the title compounds are also able to activate various enthalpically robust bonds. Further, a detailed mechanistic investigation of these small molecule activation processes reveals the non‐innocent behavior of the carbene (base) moiety attached to the GaI fragment, thereby indicating the cooperative nature of these bond activation processes. The energy decomposition analysis (EDA) and activation strain model (ASM) of reactivity were also employed to quantitatively understand and rationalize the different activation processes.
Cholinergic and Nadph‐δ neurons in the pedunculopontine and laterodorsal tegmental nuclei of human and nonhuman primates
Authors: Coulombe Vincent , Goetz Laurent , Bhattacharjee Manik , Gould Peter V. , Saikali Stephan , Takech Mohamad Ali , Philippe Éric , Parent André , Parent Martin 
Published: December 2023

AbstractThe brainstem pedunculopontine (PPN) and laterodorsal tegmental (LDTg) nuclei are involved in multifarious activities, including motor control. Yet, their exact cytoarchitectural boundaries are still uncertain. We therefore initiated a comparative study of the topographical and neurochemical organization of the PPN and LDTg in cynomolgus monkeys (Macaca fascicularis) and humans. The distribution and morphological characteristics of neurons expressing choline acetyltransferase (ChAT) and/or nicotinamide adenine dinucleotide phosphate diaphorase (Nadph‐δ) were documented. The number and density of the labeled neurons were obtained by stringent stereological methods, whereas their topographical distribution was reported upon corresponding magnetic resonance imaging (MRI) planes. In both human and nonhuman primates, the PPN and LDTg are populated by three neurochemically distinct types of neurons (ChAT‐/Nadph‐δ+, ChAT+/Nadph‐δ‐, and ChAT+/Nadph‐δ+), which are distributed according to a complex spatial interplay. Three‐dimensional reconstructions reveal that ChAT+ neurons in the PPN and LDTg form a continuum with some overlaps with pigmented neurons of the locus coeruleus, dorsally, and of the substantia nigra (SN) complex, ventrally. The ChAT+ neurons in the PPN and LDTg are —two to three times more numerous in humans than in monkeys but their density is —three to five times higher in monkeys than in humans. Neurons expressing both ChAT and Nadph‐δ have a larger cell body and a longer primary dendritic arbor than singly labeled neurons. Stereological quantification reveals that 25.6% of ChAT+ neurons in the monkey PPN are devoid of Nadph‐δ staining, a finding that questions the reliability of Nadph‐δ as a marker for cholinergic neurons in primate brainstem.
Cytoarchitectonic and connection stripes in the dysgranular insular cortex in the macaque monkey
Authors: Krockenberger Matthias S. , Saleh‐Mattesich Tatianna O. , Evrard Henry C. 
Published: December 2023

AbstractThe insula has been classically divided into broad granular, dysgranular, and agranular architectonic sectors. We previously proposed a novel partition, dividing each sector into four to seven sharply delimited architectonic areas, with the dysgranular areas being possibly further subdivided into subtle horizontal partitions or “stripes.” In architectonics, discrete subparcellations are prone to subjective variability and need being supported with additional neuroanatomical methods. Here, using a secondary analysis of indirect connectional data in the rhesus macaque monkey, we examined the spatial relationship between the dysgranular architectonic stripes and tract‐tracing labeling patterns produced in the insula with injections of neuronal tracers in other cortical regions. The injections consistently produced sharply delimited patches of anterograde and/or retrograde labeling, which formed stripes across consecutive coronal sections of the insula. While the overall pattern of labeling on individual coronal sections varied with the injection site, the boundaries of the patches consistently coincided with architectonic boundaries on an adjacent cyto‐ (Nissl) and/or myelo‐ (Gallyas) architectonic section. This overlap supports the existence of a fine dysgranular stripe‐like partition of the primate insula, with possibly major implications for interoceptive processing in primates including humans. The modular organization of the insula could underlie a serial stream of integration from a dorsal primary interoceptive cortex toward progressively more ventral egocentric “self‐agency” and allocentric “social” dysgranular processing units.