bluuebunny/crossref_metadata_2025_split huggingface dataset:
HOW TO DEVELOP HALAL TOURISM AT MOUNT WILIS MADIUN DESTINATION
Authors: Febriana Layin Lia , Prasetiyo Luhur 
Published: December 2023

Abstract: The Ministry of Tourism and Creative Economy has identified halal tourism as a significant area of focus. The slope of Mount Wilis possesses the potential to emerge as a tourism attraction that caters to the needs and preferences of Muslim travelers. The slopes of Mount Wilis possess significant potential to serve as an emblematic halal tourist destination in western East Java, thereby contributing to the development of tourism in the region. The present study employed a qualitative research methodology. The data was obtained via interviews conducted with tourism stakeholders in the regions of Watu Rumpuk and Taman Gligi. Furthermore, the process of data triangulation involved the utilization of observation. The findings show that the tourism industry in the slope of Mount Wilis exhibits promising prospects for the development of halal tourism. This paper proposes a strategic approach to foster the growth of halal tourism in the regions of Watu Rumpuk and Taman Gligi through collaborative efforts among many stakeholders. The key areas of focus for this collaboration include enhancing the quality of services, preserving the natural environment, improving communication channels, and ensuring accessibility for halal tourism.
Keywords: Potential; Strategy; Halal Tourism; Mount Wilis

Abstrak: Kementerian Pariwisata dan Ekonomi Kreatif telah menjadikan wisata halal sebagai fokus pengembangan sector pariwisata yang potensial. Lereng Gunung Wilis memiliki potensi untuk menjadi daya tarik pariwisata yang memenuhi kebutuhan dan preferensi wisatawan Muslim. Lereng Gunung Wilis memiliki potensi baik untuk dikembangkan menjadi destinasi wisata halal yang ikonik di wilayah barat Jawa Timur, sehingga dapat berkontribusi pada pengembangan pariwisata di wilayah tersebut. Penelitian ini menggunakan metodologi penelitian kualitatif. Data diperoleh melalui wawancara yang dilakukan dengan pemangku kepentingan pariwisata di wilayah Watu Rumpuk dan Taman Gligi. Selain itu, proses triangulasi data melibatkan penggunaan observasi. Temuan menunjukkan bahwa industri pariwisata di lereng Gunung Wilis menunjukkan prospek yang menjanjikan untuk pengembangan pariwisata halal. Makalah ini mengusulkan pendekatan strategis untuk memajukan pertumbuhan pariwisata halal di wilayah Watu Rumpuk dan Taman Gligi melalui upaya kolaboratif antara banyak pemangku kepentingan. Adapun fokus kerjasama ini mencakup peningkatan kualitas layanan, pelestarian lingkungan alam, perbaikan saluran komunikasi, dan memastikan aksesibilitas pariwisata halal.
Kata Kunci: Potensi; Strategi; Pariwisata Halal; Gunung Wilis
Calibrating polypropylene particle model parameters with upscaling and repose surface method
Authors: Sudsawat Supattarachai , Chongchitpaisan Pornchai , Arunyanart Pirapat 
Published: December 2023

The discrete element method (DEM) is a computational technique extensively utilized for simulating particles on a large scale, specifically focusing on granular materials. Nonetheless, its implementation requires a substantial amount of computational power and accurate material properties. Consequently, this study delves into an alternative approach referred to as volume-based scaled-up modeling, aiming to simulate polypropylene particles using DEM while mitigating the computational burden and regenerating new material properties. This novel method aims to reduce the CPU time required for the simulation process and represent both the macro mechanical behavior and micro material properties of polypropylene particles. To accomplish this, the dimensions of the polypropylene particles in the DEM simulation were magnified by a factor of two compared to the original size of the prolate spheroid particles. In order to determine the virtual micro material properties of the polypropylene particles, a calibration method incorporating the design of experiments (DOE) and repose surface methodology was employed. The predicted bulk angle of repose (AOR) derived from the upscaled DEM parameters exhibited a remarkably close agreement with the empirical AOR test, demonstrating a small relative error of merely 1.69 %. Moreover, the CPU time required for the upscaled particle model proved to be less than 71 % of that necessary for the actual-scale model of polypropylene particles. These compelling results confirm the effectiveness of enlarging the particle volume used to calibrate micro-material properties in the Discrete Element Method (DEM) through the DOE technique. This approach proves to be a reliable and efficient method
Integridade acadêmica no contexto da Ciência Aberta
Authors: Rezende Laura Vilela Rodrigues , Stueber Ketlen , Monteiro Elizabete Cristina de Souza de Aguiar , Silva Fabiano Couto Corrêa da , Oliveira Alexandre Faria de , Alves Romulo Arantes 
Published: December 2023

O processo de abertura do fazer científico envolve questões éticas, legais e de integridade acadêmica que devem, com base no rigor científico, ser sistematizadas por regras que amparam a produção do conhecimento visando o desenvolvimento de práticas responsáveis, fortalecendo a transparência no processo investigativo. Este estudo qualitativo analisou como os pesquisadores brasileiros informaram nos planos de gestão de dados (PGD) como planejam lidar com questões éticas e legais durante suas pesquisas. Buscou-se entender como lidam com questões de privacidade e integridade dos sujeitos partícipes considerando o destino dos dados a serem gerados/coletados. Foram analisadas as respostas sobre questões éticas, direitos autorais e propriedade intelectual provenientes dos PGD disponíveis publicamente na ferramenta DMPTool. Como resultados, foram identificadas poucas considerações sobre o processo de abertura do fazer científico visando o desenvolvimento de práticas responsáveis fortalecendo a transparência no processo investigativo. Sugere-se que as comunidades científicas devem fundamentar suas condutas considerando a integridade acadêmica não somente no escopo de comitês e conselhos de ética, mas também incluindo princípios da Ciência Aberta, em diferentes esferas do ecossistema científico, uma vez que se faz necessário informar locais de armazenamento, realizar descrições detalhadas dos dados científicos e normas de abertura, dentre outros procedimentos que devem ser difundidos.
Blood Biomarkers Discriminate Cerebral Amyloid Status and Cognitive Diagnosis when Collected with ACD-A Anticoagulant
Authors: Green Zachary D. , Kueck Paul J. , John Casey S. , Burns Jeffrey M. , Morris Jill K. 
Published: December 2023

Background:
The development of biomarkers that are easy to collect, process, and store
is a major goal of research on current Alzheimer’s Disease (AD) and underlies the growing interest
in plasma biomarkers. Biomarkers with these qualities will improve diagnosis and allow for better
monitoring of therapeutic interventions. However, blood collection strategies have historically differed
between studies. We examined the ability of various ultrasensitive plasma biomarkers to predict
cerebral amyloid status in cognitively unimpaired individuals when collected using acid citrate
dextrose (ACD). We then examined the ability of these biomarkers to predict cognitive impairment
independent of amyloid status.

Method:
Using a cross-sectional study design, we measured amyloid beta 42/40 ratio, pTau-181,
neurofilament-light, and glial fibrillary acidic protein using the Quanterix Simoa® HD-X platform.
To evaluate the discriminative accuracy of these biomarkers in determining cerebral amyloid status,
we used both banked plasma and 18F-AV45 PET cerebral amyloid neuroimaging data from 140
cognitively unimpaired participants. We further examined their ability to discriminate cognitive
status by leveraging data from 42 cognitively impaired older adults. This study is the first, as per
our knowledge, to examine these specific tests using plasma collected using acid citrate dextrose
(ACD), as well as the relationship with amyloid PET status.

Results:
Plasma AB42/40 had the highest AUC (0.833, 95% C.I. 0.767-0.899) at a cut-point of
0.0706 for discriminating between the two cerebral amyloid groups (sensitivity 76%, specificity
78.5%). Plasma NFL at a cut-point of 20.58pg/mL had the highest AUC (0.908, 95% CI 0.851-
0.966) for discriminating cognitive impairment (sensitivity 84.8%, specificity 89.9%). The addition
of age and apolipoprotein e4 status did not improve the discriminative accuracy of these biomarkers.

Conclusion:
Our results suggest that the Aβ42/40 ratio is useful in discriminating clinician-rated
elevated cerebral amyloid status and that NFL is useful for discriminating cognitive impairment
status. These findings reinforce the growing body of evidence regarding the general utility of these
biomarkers and extend their utility to plasma collected in a non-traditional anticoagulant.
The Importance of Traditional Chinese Medicine in the Intervention and Treatment of HIV while Considering its Safety and Efficacy
Authors: Shahrajabian Mohamad Hesam , Sun Wenli 
Published: December 2023

Abstract:
Natural products have been considered a potential resource for the development of novel
therapeutic agents, since time immemorial. It is an opportunity to discover cost-effective and
safe drugs at the earliest, with the goal to hit specific targets in the HIV life cycle. Natural products
with inhibitory activity against human immunodeficiency virus are terpenes, coumarins,
flavonoids, curcumin, proteins, such as lectins, laccases, bromotyrosines, and ribosome-inactivating
proteins. Terpenes inhibit virus fusion, lectins and flavonoids have an inhibitory impact on viral
binding, curcumin and flavonoids inhibit viral DNA integration. The most important medicinal
plants which have been used in traditional Chinese medicinal sciences with anti-HIV properties
are Convallaria majalis, Digitalis lanata, Cassia fistula, Croton macrostachyus, Dodonaea angustifolia,
Ganoderma lucidum, Trametes versicolor, Coriolus versicolor, Cordyceps sinensis, Gardenia
jasminoides, Morus alba, Scutellaria baicalensis, Ophiopogon japonicus, Platycodon grandiflorus,
Fritillaria thunbergii, Anemarrhena asphodeloides, Trichosanthes kirilowii, Citrus reticulata,
Glycyrrhiza uralensis, Rheum officinale, Poria cocos, Rheum palmatum, Astragalus membranaceus,
Morinda citrifolia, Potentilla kleiniana, Artemisia capillaris, Sargassum fusiforme,
Piperis longi fructus, Stellera chamaejasme, Curcumae rhizoma, Dalbergia odorifera lignum,
Arisaematis Rhizoma preparatum, and Phellodendron amurense. The information provided is
gathered from randomized control experiments, review articles, and analytical studies and observations,
which are obtained from different literature sources, such as Scopus, Google Scholar,
PubMed, and Science Direct from July 2000 to August 2023. The aim of this review article is to
survey and introduce important medicinal plants and herbs that have been used for the treatment
of HIV, especially the medicinal plants that are common in traditional Chinese medicine, as research
to date is limited, and more evidence is required to confirm TCM,s efficacy.
Artificial Intelligence for the Management of Breast Cancer: An
Overview
Authors: Gandhi Harshita , Kumar Kapil 
Published: December 2023

Abstract:
Breast cancer is a severe global health problem, and early detection, accurate diagnosis,
and personalized treatment is the key to improving patient outcomes. Artificial intelligence (AI) and
machine learning (ML) have emerged as promising breast cancer research and clinical practice tools
in recent years. Various projects are underway in early detection, diagnosis, prognosis, drug discovery,
advanced image analysis, precision medicine, predictive modeling, and personalized treatment
planning using artificial intelligence and machine learning. These projects use different algorithms,
including convolutional neural networks (CNNs), support vector machines (SVMs), decision trees,
and deep learning methods, to analyze and improve different types of data, such as clinical, genomic,
and imaging data for breast cancer management. The success of these projects has the potential to
transform breast cancer care, and continued research and development in this area is likely to lead to
more accurate and personalized breast cancer diagnosis, treatment, and outcomes.
Metabolomics: Recent Advances and Future Prospects Unveiled
Authors: Sharma Shweta , Singh Garima , Akhter Mymoona 
Published: December 2023

Abstract:
In the era of genomics, fueled by advanced technologies and analytical tools, metabolomics
has become a vital component in biomedical research. Its significance spans various domains,
encompassing biomarker identification, uncovering underlying mechanisms and pathways,
as well as the exploration of new drug targets and precision medicine. This article presents a comprehensive
overview of the latest developments in metabolomics techniques, emphasizing their
wide-ranging applications across diverse research fields and underscoring their immense potential
for future advancements.
Differences in the Model of Eating in the Absence of Hunger Before and During the COVID-19 Pandemic
Authors: Cahyani Anggita Dian , Iskandarsyah Aulia , Cahyadi Surya , Srisayekti Wilis 
Published: December 2023

Introduction:
The obesity rate among adults in Indonesia continues to increase, and even almost doubles in a decade. In the study of eating behavior, one of the causes of obesity is due to eating out of hunger. The study has proposed a conceptual model of eating in the absence of hunger [EAH]. EAH was examined through the influence of eating styles and hedonic hunger. In addition, the mediating role of palatable eating motives and loss of control over eating were also included in the model. In this paper, we mainly focused on the influence of environmental situation namely the occurrence of the COVID-19 pandemic. It was necessary to see whether the COVID-19 pandemic situation would make a difference to the proposed model. The study aimed to compare data taken before COVID-19 with data taken during the COVID-19 pandemic.

Methods:
This study involved 753 respondents who were dominated by female and university students aged 18-25 years who were studying in Jakarta using convenience sampling. Data were collected using a self-report questionnaire. The data before the COVID-19 pandemic was collected in February -March 2020 by paper and pencil. The data during COVID-19 was collected using the online form in June-July 2020. Data were analyzed using multigroup analysis.

Results:
The analysis results denoted that the model proposed was fit with the data even though the two data groups were not invariant.

Conclusion:
This means that special situations, such as the COVID-19 pandemic have an impact on EAH.
Health System Responsiveness in the Primary Health in a Developing Country: Expectations and Experiences of Clients
Authors: Ahmadpour Sima , Iranag Jamileh Amirzadeh , Yusefzadeh Hasan , Nabilou Bahram 
Published: December 2023

Background:
Healthcare responsiveness is an essential goal of health systems. Responsiveness focuses on the nonclinical aspects of healthcare and measures individuals; experiences. There is little knowledge about responsiveness in primary care; most responsiveness studies have focused on inpatient services.

Objectives:
This study aimed to assess the responsiveness of primary care in the Urmia District Health Network in northwestern Iran.

Methods:
Data collection was conducted at urban health centers. The data presented are from a single observational research project.

Results:
Two hundred forty regular clients were interviewed in selected urban health centers in the Urmia district health network. The mean total response score was satisfactory. Full access and easy receipt of services without discrimination were important and noteworthy results for responsiveness. Regarding respondents, expectations, dignity, and prompt attention were the most important domains, while provider choice and social support were the least important. The results showed no statistically significant differences between the mean responsiveness scores for ambulatory care and hospital services.

Conclusion:
Improvements in responsiveness domains increase convergence and alignment between clients' expectations and health system performance. In this context, dignity and prompt attention are essential.
A Mini-review on the Chemical Composition, Extraction and Isolation
Techniques, and Pharmacological Activity of Rosmarinus officinalis L.
Authors: Lin Xiao , Haimeng Luo , Xiaoyun Ji , Yaoyao Ren , Xianqing Wu , Hezhong Jiang 
Published: December 2023

Abstract:
Rosmarinus officinalis L. belongs to the genus Rosemary in the family Labiatae, which
is a perennial evergreen subshrub. It is currently cultivated in certain areas of Yunnan, Guangxi,
and Guizhou. At present, in food, cosmetics, healthcare products, and other domains, R. officinalis
has a wide range of applications; it has received widespread attention, and is also a hot topic of
research today. Using modern spectroscopic techniques, it has been found that the main chemical
components of rosemary can be divided into two major groups, including volatile components
(essential oils) and non-volatile components (diterpenes, triterpenes, flavonoids, phenolic acids,
sterols, etc.). Among them, carnosic acid, carnosol, rosemary phenol, and 1,8-cineole are the main
components acting as antioxidants and they are highly regarded. The main methods for extracting
the active ingredients of R. officinalis include water distillation, ultrasonic-assisted microwave
method, supercritical CO2 extraction method, enzyme-assisted extraction method, and microwaveassisted extraction method. Modern research has shown that rosemary has anti-inflammatory, antioxidant, antibacterial, antiviral, antitumor, hepatoprotective, hypolipidemic, immunomodulatory,
antiseptic, and antithrombotic effects, and is widely used in medical applications.
Pembelajaran tenis pada multimedia berbasis android untuk pendidikan sekolah menengah atas
Authors: Laksono Hutomo Adhadi 
Published: December 2023

Penelitian ini bertujuan untuk (1) mengembangkan media pembelajaran tenis lapangan berbasis android pada pendidikan jasmani olahraga dan kesehatan di SMA yang memenuhi unsur kelayakan, dan (2) mengungkapkan efektivitas media pembelajaran berbasis android yang dikembangkan.Penelitian pengembangan ini dilakukan dalam enam tahap yaitu meliputi: (1) analisis kebutuhan, (2) perencanaan pengembangan produk, (3) pengembangan produk, (4) uji coba produk, (5) produk akhir, dan (6) diseminasi dan implementasi.Data diperoleh melalui observasi, angket, wawancara, dan tes hasil belajar. Analisis data menggunakan t-test dengan taraf signifikansi 0,05. Hasil penelitian menunjukkan bahwa produk media pembelajaran tenis lapangan berbasis android di SMAmemiliki tingkat kelayakan yang baik.Tingkat kelayakan produk berdasarkan validasi ahli materi rata-rata sebesar 4,46 (sangat baik), validasi ahli media sebesar 4,27 (sangat baik), uji coba kelompok kecil sebesar 4,21 (baik), uji coba lapangan sebesar 4,44 (sangat baik). Selain itu, produk media yang dikembangkan efektif untuk digunakan dalam proses pembelajaran. Hal tersebut dibuktikan oleh hasil pretest dan posttest. Pada uji coba lapangan hasil tes menunjukkan bahwa peserta didik mampu meningkatkan nilai rata-rata hasil belajar dari 60,43 menjadi 84,23 dengan nilai p 0,005, sehingga terdapat kenaikan yang signifikan dengan p = 0,000. Tennis learning on Android-based multimedia for high school education Abstract: This study aims to (1) develop a feasible tennis learning multimedia based on Android in physical, sports, and health education at school and (2) reveal the effectiveness of the developed learning media. This research and development were carried out in six stages, which referred to the measures developed by Borg Gall, including (1) analysis of needs, (2) planning of product development, (3) product development, (4) testing the products, (5) final product, and (6) dissemination and implementation. The data were obtained through observation, questionnaires, interviews, and achievement tests. The data analysis used the t-test at a significance level of 0.05. The results showed that the developed tennis learning multimedia based on Android in physical, sports, and health education at school has a good level of feasibility. Based on material expert validation, it has an average of 4.46 (very good); by media expert validation, it has 4.27 (very good); by a small group, it has 4.21 (good). By field trials, it has 4.44 (very good). In addition, the developed media is effective for use in the learning process. The results of the pretest and posttest evidence this. The field trial test results show that the students are able to increase the learning outcomes from 60.43 to 84.23 with p0.0005, so there is a significant increase, with p=0.000.
PERANCANGAN PARTISIPATIF MASTERPLAN GLAMPING AREA DALAM RENCANA PENATAAN KAWASAN GAMAT BAY NUSA PENIDA, BALI
Authors: Prabawa Made Suryanatha 
Published: December 2023

Perancangan Glamping area ini merupakan kegiatan pengabdian masyarakat dalam pendampingan penyusunan masterplan Kawasan Gamat Bay, Nusa Penida. Mitra pengabdian adalah Desa Sakti demham lokasi lahan pada kawasan hutan lindung Kawasan Desa Sakti. Kawasan hutan lindung tersebut terletak di Tanjung Gamat (Gamat Bay), yang saat ini sedang dalam proses konversi tata guna menjadi hutan desa. Beralih fungsi menjadi Hutan Desa akan lebih memudahkan untuk dikembangkan menjadi Daerah Tujuan Wisata (DTW). Pengabdian ini dilakukan bekerjasama dengan seluruh tokoh masyarakat dan perangkat desa Sakti di bawah arahan Kepala Desa Sakti I Ketut Partita. Pengabdian akan dilaksanakan berbasis pada perancangan arsitektur partisipatif dengan melibatkan seluruh pemangku kepentingan yakni kepala Desa Sakti, POKDARWIS, dan Tokoh Masyarakat. Masterplan Glamping Area berisikan pemaparan mengenai Analisis Site, Kebutuhan Ruang, Konsep dan Tema Perancangan Arsitektur, Layout Plan, 3D Visualisasi, dan Skema Strategi Pemasaran Glamping Area. Glamping Area ini didominasi dengan Bangunan bersifat Temporer bersistem Knock Down dan menerapkan prinsip arsitektur vernacular. Dokumen Masterplan yang tersusun memberikan dampak ekonomis dan social yang cukup membuat warga merasa bangga dan antusias dan siap dalam mengawal perencanaan ini sampai pada tahap eksekusi konstruksi.
The Government Use and Compulsory License: Questioning the Patent Application of Drug and Covid-19 Vaccines
Authors: Rohaini Rohaini , Dwiatin Lindati , Eka R Dianne 
Published: December 2023

The pandemic of Covid-19 and the urgent global needs to immediately obtain an effective drugs or Covid-19 vaccines have impacted the competition of pharmaceutical inventions and the patent registration of drugs or Covid-19 vaccines. However, this circumstance raise pro and cons. There is concern that there will be a conflict between the economic interests of the patent holder and public interest. Patent rights granted to the inventors or pharmaceutical companies has caused difficulties of the State to provide medicines or vaccines to the public since the production and distribution of it has been fully under their control. In this regard, the government use and compulsory license mechanisms are believed to be the most likely policies by the Government for balancing the use of exclusive rights and the economic interests of patent holders. It allow the Government to access and exploit patented inventions without prior consent from the patent holder, but at the same time the patent holder still get the protection and their rights.