bluuebunny/crossref_metadata_2025_split huggingface dataset:
Comparison of metabolic differences between two geometrical isomers based on multi‐omics strategy
Authors: Ge Xiaoyan , Gao Jian , Zhang Xue , Wang Liming , Wang Chenxi , Fu Zhifei , Yu Haiyang , Liu Erwei , Wang Linlin , Liu Ping , Han Lifeng 
Published: November 2023

Abstract2,3,5,4′‐tetrahydroxy stilbene‐2‐O‐β‐D‐glucoside is the main compound of Polygonum multiflorum. There are two geometrical isomers of 2,3,5,4′‐tetrahydroxy stilbene‐2‐O‐β‐D‐glucoside. Several studies have shown that cis‐2,3,5,4′‐tetrahydroxy stilbene‐2‐O‐β‐D‐glucoside may be the risk compound of hepatotoxicity in Polygonum multiflorum Thunb. and there are few comprehensive comparisons on the different impacts of cis‐2,3,5,4′‐tetrahydroxy stilbene‐2‐O‐β‐D‐glucoside and trans‐2,3,5,4′‐tetrahydroxy stilbene‐2‐O‐β‐D‐glucoside about metabolic characteristics. This paper aimed to provide a comprehensive assessment of the metabolomics and lipidomics studies of the differences in metabolic characteristics of cis‐2,3,5,4′‐tetrahydroxy stilbene‐2‐O‐β‐D‐glucoside and trans‐2,3,5,4′‐tetrahydroxy stilbene‐2‐O‐β‐D‐glucoside. The results showed that trans‐2,3,5,4′‐tetrahydroxy stilbene‐2‐O‐β‐D‐glucoside and cis‐2,3,5,4′‐tetrahydroxy stilbene‐2‐O‐β‐D‐glucoside significantly affected 47 metabolites. The main interfering pathways included alpha‐linolenic acid, linoleic acid (LA) metabolism, arachidonic acid (AA) metabolism, and fatty acid metabolism. According to the transcriptomics study, the altered genes were mainly enriched in LA metabolism, AA metabolism, and fatty acid metabolism. Two genes (Runx3 and Scd1) were mainly involved in the cell cycle and fatty acid metabolism in the cis‐2,3,5,4′‐tetrahydroxy stilbene‐2‐O‐β‐D‐glucoside group, and one enzyme (Phospholipase B1) was related to alpha‐linolenic acid, LA metabolism and AA metabolism in the trans‐2,3,5,4′‐tetrahydroxy stilbene‐2‐O‐β‐D‐glucoside group. These would provide useful information for further investigation on therapeutic and hepatotoxic mechanisms of Polygonum multiflorum Thunb.
A latent space accumulator model for response time: Applications to cognitive assessment data
Authors: Jin Ick Hoon , Yun Jonghyun , Kim Hyunjoo , Jeon Minjeong 
Published: November 2023

AbstractResponse time has attracted increased interest in educational and psychological assessment for, for example, measuring test takers' processing speed, improving the measurement accuracy of ability and understanding aberrant response behaviour. Most models for response time analysis are based on a parametric assumption about the response time distribution. The Cox proportional hazard model has been utilized for response time analysis for the advantages of not requiring a distributional assumption of response time and enabling meaningful interpretations with respect to response processes. In this paper, we present a new version of the proportional hazard model, called a latent space accumulator model, for cognitive assessment data based on accumulators for two competing response outcomes, such as correct versus incorrect responses. The proposed model extends a previous accumulator model by capturing dependencies between respondents and test items across accumulators in the form of distances in a two‐dimensional Euclidean space. A fully Bayesian approach is developed to estimate the proposed model. The utilities of the proposed model are illustrated with two real data examples.
Serological evidence and factors associated with Crimean–Congo haemorrhagic fever in sheep in Burkina Faso
Authors: Dahourou Laibané Dieudonné , Akio Salimata , Savadogo Madi , Yougbaré Bernadette , Ouoba Lalidia Bruno , Tapsoba Arnaud Stéphane Rayangnéwêndé , Zerbo Lamouni Habibata , Ilboudo Abdoul Kader , Abga Roland Lamoussa , Traoré Amadou , Dione Michel Mainack , Bada Alambédji Rianatou 
Published: November 2023

AbstractBackgroundCrimean–Congo haemorrhagic fever (CCHF) is caused by an orthonairovirus transmitted by bites from infected ticks or by direct contact with blood or tissues of infected ticks, viraemic patients or viraemic livestock.ObjectiveIt was implemented to access the seropositivity and associated factors with CCHF in sheep in two provinces in Burkina Faso.MethodsThree hundred and sixty‐four sheep sera have been taken from 73 herds in four municipalities and two provinces. The double‐antigen sandwich ELISA test was used to test for antibodies against CCHF virus (CCHFV). Data have also been collected using questionnaire to assess factors associated with CCHF seropositivity.ResultsFifty‐four (54 out to 364 sheep were seropositive given an overall seropositivity of 14.8% (95% confidence interval [CI]: 10.9%–19.8%) with an adjusted seropositivity of 13.1%. The study showed that 15.6% (95% CI: 10.2–21.0) and 14.1% (95% CI: 9.2–19.1) of sheep in the provinces of Mouhoun and Kénédougou, respectively, had antibodies against CCHFV. The highest seropositivity was found in Dédougou municipality (24.4%). The study showed that sheep from the municipalities of Dédougou (AOR = 8.4; 95% CI: 2.2–31.8), N'dorola (AOR = 14.7; 95% CI: 3.8–56.8), Sindou (AOR = 4.9; 95% CI: 1.2–20.7), sheep aged between 27 and 36 months (AOR = 6.4; 95% CI: 2.3–17.3) and sheep with ticks (AOR = 24.8; 95% CI: 7.7–80.1) were more likely to be seropositive to CCHF.ConclusionsThe study revealed that sheep in Burkina Faso experienced contacts with CCHFV and suggests the importance of implementing control action in the country.
The first report of rabies in stone marten (Martes foina) in Chaharmahal and Bakhtiari Province (Iran)
Authors: Zamzam Seyed Hossein , Ghorani Mohammadreza , Eslami Fahime , Mostofi Saeed 
Published: November 2023

AbstractRabies is a prevalent endemic and zoonotic fatal disease, which is normally transmitted to humans by contact (scratches and bites) from infected animals. The present paper deals with the first documented evidence of rabies in the stone marten (Martes foina). Rabies symptoms were observed in a marten in Chaharmahal and Bakhtiari province. The animal with a strange demeanour approached people without fear, which was died after some while. Samples were taken from its brain (cerebellum, hippocampus, and hypothalamus), shortly after death. In this report, laboratory evidence of rabies by fluorescent antibody (FAT) was proved. The present work is valuable because of the environmental importance of the stone marten. Hence, sensitive surveillance and advanced reporting systems should be regularly monitored on suspected cases of rabies in animals and humans to control and prevent this deadly disease. This involves exposure history, clinical examinations, symptoms and experimental results. Rabies can be controlled by fast diagnostic tests and vaccination.
Photochromic properties of novel composites on the base of biopolymers and plasma‐modified Mo4O11 and W18O49 nanostructures
Authors: Khlyustova Anna , Evdokimova Anastasia , Shibaeva Valeria , Sirotkin Nikolay 
Published: November 2023

AbstractNovel photochromic composites based on biopolymers (polyvinyl alcohol, starch) and Mo4O11 and W18O49 as the fillers were obtained and characterized. To improve the photochromic properties, molybdenum and tungsten oxide sols were treated by an underwater diaphragm discharge to obtain binary structures of the MoOx/WOx and WOx/MoOx (2 < x < 3) types. The formation of such oxides was confirmed by TEM, EDX, XRD analysis, and Raman spectroscopy data. Plasma treatment is increased the color intensity and reversibility. The modified sols were incorporated into polymer matrices. Spectral studies have shown that the color of photo‐colored composites depends on the chemical structure of the polymer matrix. Mechanical tests have shown the possibility of obtaining hardened or plastic composites depending on the concentration and nature of the filler.Highlights
Photochromic polymer composites with W18O49 and Mo4O11 as fillers were obtained.
Diaphragm discharge used as a tool for sol modification.
WOx/MoOx and MoOx/WOx structures have improved photochromic properties.
Color of irradiated polymer composites depends on chemical structure of polymer.
Mechanical properties are determined by the polymer filler concentration.
Nonlinear thermomechanical vibration of initially stressed functionally graded plates with porosities
Authors: Anh N. D. , Van Thinh Nguyen , Van Tung Hoang 
Published: November 2023

AbstractThe large‐amplitude vibration of initially stressed functionally graded material (FGM) rectangular plates with porosities is investigated in this paper. All edges of the plate are simply supported and uncompressed edges are tangentially restrained. Initial stresses are caused by in‐plane compressive load acting on freely movable edges or thermally induced forces at restrained edges. Pores present in FGM through even and uneven distributions. Material properties are assumed to be temperature‐dependent and, due to the presence of the pores, the effective properties of FGM are determined using a modified rule of mixture. Governing equations in terms of deflection and stress function are established based on the classical plate theory taking into account von Kármán nonlinearity and initial geometric imperfection. These equations are solved using approximate analytical solutions along with the Galerkin method to obtain a time differential equation containing quadratic and cubic nonlinear terms. Nonlinear frequencies are determined by means of numerical integration employing the fourth‐order Runge–Kutta scheme. Parametric studies are carried out to analyze the effects of material and geometry properties, porosity volume fraction and distribution, pre‐existent compressive and thermal loads, imperfection and degree of tangential constraints of unloaded edges on the natural frequencies and nonlinear to linear frequency ratio of FGM plates.
Hybrid Investigative Journalism During Times of Crisis
Authors: Konow-Lund Maria , Park Michelle , Bebawi Saba 
Published: November 2023

AbstractIn pursuit of its continued focus on holding power to account—locally, nationally and globally—investigative journalism as a practice has actively incorporated various digital skills and capabilities. The embrace of digital journalism has led to collages of skillsets that have come together in new ways to complement one another or merge into something unprecedented. These processes of hybridisation are regularly discussed in relation to how journalism is undergoing riveting change; as a concept, hybridity challenges traditional notions of how journalism is being produced and by whom. Domingo (2016, p. 145), for example, points out that hybridisation is taking place within journalistic practices both overtly and covertly amongst a range of (new and traditional) actors, platforms and organisations. The hybrid combination of digital and traditional physical forms of journalistic collaboration has also given rise to new horizontal processes (Russel, 2016, p. 149).
Toward a Hybrid Future for Investigative Journalism
Authors: Konow-Lund Maria , Park Michelle , Bebawi Saba 
Published: November 2023

AbstractIn this book, we have reflected upon alternative ways forward for investigative journalism—ways which demand hybridisation, innovation and entrepreneurship. In doing so, we have also addressed a gap in the existing academic research. We deliberately considered cases which, while generally run by professional journalists, go well beyond traditional investigative journalism. These cross-disciplinary efforts in the field draw upon some traditional practices but at the same time dedicate themselves to productive and purposeful collaborations among journalists, activists, technologists, editorial developers, citizens, community coordinators and others. Such innovation within journalism, we argued, depends upon innovation at every level—locally, nationally and globally.
How COVID-19 Affected the Practice of Investigative Journalism in Norway and China
Authors: Konow-Lund Maria , Pan Lin , Gardell Eva-Karin Olsson 
Published: November 2023

AbstractUnlike other global crises, the COVID-19 pandemic offered researchers a unique opportunity to better understand the ways in which journalistic practices in the digital era could be adapted to handle new challenges. In this chapter, we are concerned with practices related to investigative journalism and social media use among journalists.
Toolkit—Tools to Assist in Making the Move into Entrepreneurship
Authors: van der Westhuizen Thea 
Published: November 2023

AbstractContinuing with the co-sensing idea of ‘connecting with people and ideas to learn more about how things work’, entrepreneurs need to act quickly and continuously. But first, as entrepreneurs, we need to know what we are going to do, what to start with, and what to do next. We need to plan our priorities. Although a lengthy business plan does not guarantee that the business will succeed, it is important to have a clear outline of its vision and action steps. This is where it helps to create a business model canvas. This chapter describes aspects relating to the SHAPE Four-Quadrant Business Model Canvas and shows how we can put our ideas into entrepreneurial action.
Toolkit—New Customers and Product Development
Authors: van der Westhuizen Thea 
Published: November 2023

AbstractThis chapter gets down to the nitty–gritty of what we are going to do: How we are going to develop a way of adding value and creating a product or service that is useful and sustainable. The key issue in the chapter is to be truly creative. The chapter discusses innovation and how our unique business offering is going to make money. So, we need to think about market research and the difference between marketing and sales. The chapter also discusses three ways to get into the market: business tendering, starting a business with no products (‘drop-shipping’), and starting a business with no money. To start a business, we sell a product to a customer. The SHAPE Lean Model highlights the importance of working out what people want; we then sell it to them and build an organisation that can continue doing this.
Impact dynamics of granular debris flows based on a small-scale physical model
Authors: Scheidl Christian , Friedl Caroline , Reider Lukas , Wernhart Susanna , Fuchs Anna-Lisa , Dankwerth Anna Lisa , Nagl Georg , Kaitna Roland , Proske Dirk 
Published: November 2023

AbstractThe peak pressure of a granular debris flow at low Froude conditions can be calculated with knowledge of the stress anisotropy and the bulk density as well as the run-up height at impact. Based on a small-scale physical model, measurements of stress anisotropy and flow density values at impact are presented and applied to existing run-up prediction models, and further compared with back-calculated run-up coefficients from measured maximum impact pressures. For this purpose, we conducted 17 experiments with impact measurements and six experiments without impact measurements at Froude numbers, ranging from 0.84 to 2.41. Our results indicate that run-up heights are best reproduced by predictive models, either based on energy or mass and moment conservation, when anisotropic stress conditions, found in this study to range from 1.2 to 5.0, and bulk density variations due to impact, ranging in this study from 0.8 to 2.3, are considered. The influence of stress anisotropy and density variation on the run-up prediction differs, depending on the modelling approach. For the calculation of run-up heights based on the energy conservation concept, the influence of stress anisotropy becomes more significant with increasing Froude number, whereas for models based on mass and momentum conservation, bulk density variations have a greater influence on the estimation of the potential run-up.
Interval appendectomy as a safe and feasible treatment approach after conservative treatment for appendicitis with abscess: a retrospective, single-center cohort study
Authors: Suzuki Toshiyuki , Matsumoto Akiyo , Akao Takahiko , Matsumoto Hiroshi 
Published: November 2023

AbstractEmergency appendectomy (EA) is the gold standard management for acute appendicitis (AA). However, whether EA or interval appendectomy (IA) after conservative treatment is the optimal approach in AA with abscess remains controversial. This study compared IA and EA in patients presenting with AA accompanied by abscess. This was a retrospective single-center study including 446 consecutive patients undergoing appendectomy between April 2009 and March 2023. AA with abscess was defined as a pericecal abscess observed by computed tomography or abdominal ultrasonography, and patients with signs of peritoneal irritation were excluded. Perioperative outcomes were compared between the patients who directly underwent EA and those who underwent IA after conservative treatment. Among 42 patients (9.4%) with AA and abscess, 34 and 8 patients underwent IA and EA, respectively. The rates of ileocecal resection and postoperative complications were lower in the IA group than in the EA group (3% vs. 50%, P < 0.001 and 9% vs. 75%, P < 0.001, respectively). Colonoscopy before IA was performed in 16 of the 17 patients aged ≥ 40 years in the IA group, and one patient underwent ileocecal resection because of suspicious neoplasm in the root of the appendix. IA after conservative treatment might be considered as the useful therapeutic option for AA with abscess. Colonoscopy during the waiting period between the initial diagnosis and IA should be considered in patients aged ≥ 40 years who may have malignant changes. Implementing IA as a first-line treatment will be beneficial to both patients and healthcare providers.
Comparative study of children’s mental health outcomes in Tyrol, Austria, and South Tyrol, Italy, during the COVID-19 pandemic
Authors: Kohlboeck Gabriele , Barbieri Verena , Wenter Anna , Piccoliori Giuliano , Engl Adolf , Sevecke Kathrin , Wiedermann Christian J. , Exenberger Silvia 
Published: November 2023

Summary
Purpose
This study aimed to compare the mental health outcomes of children in North Tyrol, Austria, and South Tyrol, Italy, during the coronavirus disease 2019 (COVID-19) pandemic, considering the sociocultural and contextual differences between the two regions.

Methods
The Tyrolean COVID-19 Children’s Study (TCCS: n = 401; June 2021 to July 2021) and the Corona and Psyche in South Tyrol 2021 Study (COP‑S; n = 3402; May 2021 to June 2021) were used for data analyses. Both studies employed cross-sectional designs and collected data through online questionnaires completed by children aged 7–13 years and their parents. Various psychosocial assessment tools including the Child and Adolescent Trauma Screening, Children Anxiety Test, Child Behavior Check List, Screen for Child Anxiety Related Emotional Disorders, and Health Behaviour in School-Aged Children were used in the surveys.

Results
The comparison between North Tyrol and South Tyrol revealed no significant differences in perceived threats, trauma, or anxiety among children. Similarly, there were no substantial disparities in psychosomatic complaints, indicating similar manifestations of emotional distress across the two regions.

Conclusion
The comparative analysis of children’s mental health outcomes in North Tyrol and South Tyrol during the COVID-19 pandemic confirmed the analogous influence of sociocultural and contextual factors on their wellbeing. Despite presumable variations in pandemic events, management strategies, and healthcare systems, the study suggests comparable resilience among children and highlights the importance of sociocultural factors in shaping their wellbeing. The findings emphasize the need for comprehensive understanding and targeted interventions to support children’s mental health during challenging times.
Snakebites in the Americas: a Neglected Problem in Public Health
Authors: Fernández C Eduardo A , Youssef Peter 
Published: November 2023

Abstract
Purpose of Review
We explored the current priority given to snakebites in 26 countries of the Americas. To describe the epidemiological characteristics of the snakebites in the Americas and the Caribbean, we looked at information collected from epidemiological sources, publications, and available from PubMed, SciELO, and LILACS. In the case of Honduras, some gray literature (theses and conference abstracts) was obtained through local networks. We also aimed at obtaining any reference made in those reports with regard to the most common snake species in the region and their toxin and the physical and mental disability in snakebite victims.

Recent Findings
Many countries do not keep official reports of the snakebite incidents. In a few countries, growing knowledge of venom toxicology is leading to research and development of new antivenoms. Additionally, interest is increasing in the identification of natural treatment for symptoms caused by snake venoms, especially inflammation, pain, and blood loss. There are opportunities to undertake rigorous examination of traditional treatments, which could be incorporated to the standard of care.

Summary
Snakebite surveillance needs improvement in several countries, and access to prompt treatment needs to be facilitated. With a few exceptions, scientific research is scarce in most Latin American countries. For prevention and management initiatives, it is important to highlight that the typical profile of the snakebite victim is a young male farmer with low literacy.
Deep Insight of Design, Mechanism, and Cancer Theranostic Strategy of Nanozymes
Authors: Yang Lu , Dong Shuming , Gai Shili , Yang Dan , Ding He , Feng Lili , Yang Guixin , Rehman Ziaur , Yang Piaoping 
Published: November 2023

AbstractSince the discovery of enzyme-like activity of Fe3O4 nanoparticles in 2007, nanozymes are becoming the promising substitutes for natural enzymes due to their advantages of high catalytic activity, low cost, mild reaction conditions, good stability, and suitable for large-scale production. Recently, with the cross fusion of nanomedicine and nanocatalysis, nanozyme-based theranostic strategies attract great attention, since the enzymatic reactions can be triggered in the tumor microenvironment to achieve good curative effect with substrate specificity and low side effects. Thus, various nanozymes have been developed and used for tumor therapy. In this review, more than 270 research articles are discussed systematically to present progress in the past five years. First, the discovery and development of nanozymes are summarized. Second, classification and catalytic mechanism of nanozymes are discussed. Third, activity prediction and rational design of nanozymes are focused by highlighting the methods of density functional theory, machine learning, biomimetic and chemical design. Then, synergistic theranostic strategy of nanozymes are introduced. Finally, current challenges and future prospects of nanozymes used for tumor theranostic are outlined, including selectivity, biosafety, repeatability and stability, in-depth catalytic mechanism, predicting and evaluating activities.