bluuebunny/crossref_metadata_2025_split huggingface dataset:
Raspberry-derived carbon dots for specific detection of intracellular copper ions
Authors: Xu Yalan , Liu Yiwei , Feng Liping , Wang Muhua , Xia Yueyi , Yang Luoxing , Yuwang Junjie , Sun Xiaoli 
Published: January 2025

Abstract

The detection of intracellular copper ions is of significant importance in biomedical research and disease diagnosis. In this study, blue emissive carbon dots (B-CDs) were successfully synthesized using raspberries as a carbon source through a simple hydrothermal method. Transmission electron microscopy (TEM) analysis revealed that the B-CDs had an average particle size of 9.05 nm. Characterization techniques combined with theoretical calculations, confirmed that the fundamental structural unit of B-CDs is a twelve-membered aromatic ring rich in oxygen and nitrogen functional groups. The B-CDs exhibited high selectivity for Cu²⁺ ions, showing a strong linear response in the concentration range of 0 to 150 µM, with a detection limit of 0.39 µM. Zeta potential and hydrodynamic size measurements indicated that the B-CDs interact with Cu²⁺ ions via electrostatic forces. Further studies revealed that the fluorescence quenching of B-CDs in the presence of Cu²⁺ is primarily due to a dynamic quenching process. Moreover, B-CDs were successfully applied to detect intracellular Cu²⁺. These findings not only show significant potential of B-CDs in fluorescence sensing but also provide valuable insights for the design of efficient carbon-based sensors.
Harmonic Oscillator with Variable Damping Coefficient
Authors: N Vinoj M , S Rajesh , G Seema V 
Published: January 2025

Abstract

Damped harmonic oscillator with damping coefficient as a linear function of position coordinate is represented by nonlinear ordinary differential equation. Solution of this equation is studied using both two-timing perturbation method and numerical method. Both solutions match exactly eventhough the perturbation term is not infinitesimally small in the underdamped case. The rate of variation of energy is found to be very slowly when damping coefficient varies as a linear function position coordinate as compared with constant damping case. There exist only one critical point, the origin, which is asymptotically stable in the underdamped situation. In the critically damped and overdamped conditions the critical point behaves like stable node.
Metacognition’s Moderation Effect between Engagement with Large Language Model and Reflection of Its Usage in EFL Writing among Chinese University Students
Authors: Song Jun 
Published: January 2025

Abstract

As a contributor to success in EFL (English as a foreign language) learning, the function of metacognition in digital intelligence era needs exploration. The study aimed to explore whether metacognition was functional when manipulating Large Language Models (LLM) to EFL writing. The present study adopted the moderation modeling approach to examine the interactive effect of metacognition implied between Chinese university students’ engagement with LLM and their reflection of LLM usage in EFL writing. 212 Students who graduated from Chinese tertiary institutions and studied at Chinese tertiary institutions currently are recruited as participants. They were required to complete a modified questionnaire containing 20 5-point Likert items to investigate whether their engagement with LLM could positively affect their reflection of LLM usage in EFL writing, and whether or not an effect is significant in predicting reflection of LLM usage when looking at the interaction effect between engagement with LLM and metacognition. The potential influence between engagement with LLM and reflection of LLM usage in EFL writing was statistically significant via simple linear regression. Moderation analysis retrieved from Sato’s (2023) research examined metacognition as an interaction term between engagement with LLM and reflection of LLM usage, however, the role of metacogntion was also not effective. Findings suggest that LLM is effective for EFL writing class, while what kind of factor on reflection of LLM usage will be influenced by metacognition still needs further exploration.
Single-Position Robot-Assisted Laparoscopic Nephroureterectomy for Duplicated Kidneys and Ureters: Technique and Outcomes
Authors: Sun Wei-Cheng , Zhang Feng , Sun Jia-Ning , Wang Xiao-Yan , Tang Gong-Lin , Chen Xin , Liu Chen-Yue , Zhao Jun-Dong , Zhao Hong-Wei 
Published: January 2025

Abstract

Purpose
Robot-assisted laparoscopic nephroureterectomy has reached a high level of maturity. However, operating on patients with duplex kidneys presents added challenges, primarily due to the large-scale resection and the need for re-positioning. This study aims to elaborate on the technique and outcomes of single-position robot-assisted nephroureterectomy for duplicated kidneys and ureters.
Methods
In our department, 23 patients diagnosed with duplicated renal collecting systems were selected. 10 patients underwent single-position robot-assisted laparoscopic nephroureterectomy (single-position group), and 13 had traditional robot-assisted laparoscopic nephroureterectomy (non-single-position group). We systematically collected their demographic data, surgical indications, and perioperative variables, and meticulously evaluated the surgical outcomes.
Results
All 23 patients underwent successful surgeries without conversion to open procedures. No remarkable differences were detected in the baseline clinical characteristics. The single-position group had a shorter operation time (166.20 ± 21.29 min vs. 208.31 ± 23.30 min, p < 0.001) and drainage tube indwelling time (3.50 ± 0.53 days vs. 4.15 ± 0.69 days, p < 0.05). Additionally, a statistically significant disparity in estimated blood loss (EBL) was noted between the two groups (136.00 ± 18.14 ml vs. 165.77 ± 40.72 ml, p < 0.05). There were no differences in post-operative hospital stays and pre-and post-operative estimated glomerular filtration rate (eGFR), and no recurrence was observed.
Conclusion
Single-position robot-assisted nephroureterectomy is both a reliable and secure surgical treatment for duplicated renal collecting systems, offering benefits such as reduced operative time, minimal minor complications, less estimated blood loss, and a high rate of surgical success.
Unraveling the association between retinal thickness and Alzheimer's disease, and circulating total-tau levels: Insights from genetic evidence
Authors: Sheng Dandan , Wang Song , Xiao Zheng , Liu Weiping , Xiao Bo , Zhou Luo 
Published: January 2025

Abstract

Background
Observational studies have reported associations between retinal thickness and Alzheimer’s disease (AD); however, the causal relationship remains uncertain.
Methods
We investigated the potential causal relationship between retinal thickness and AD using Mendelian randomization (MR) and genetic colocalization analyses. Multiple genome-wide association studies (GWAS) of European ancestry were used for MR causal inference. Summary-level data on retinal nerve fiber layer (RNFL) and ganglion cell-inner plexiform layer (GC-IPL) thickness were sourced from the UK Biobank (N = 31,434). AD data were obtained from a GWAS meta-analysis conducted by the International Genomics of Alzheimer’s Project for discovery (N = 63,926) and an independent European GWAS cohort for replication (N = 85,934). Circulating total-tau biomarker data were derived from another GWAS in individuals of European ancestry (N = 14,721). The inverse-variance weighted (IVW) method served as the primary analytical approach, supplemented by MR-Egger, robust adjusted profile score, maximum likelihood, and weighted median methods. Sensitivity analyses included Cochran’s Q test, MR-Egger intercept test, leave-one-out analysis, and MR pleiotropy residual sum and outlier analysis to ensure robustness. Genetic colocalization analysis was performed to identify potential shared causal variants between retinal thickness and AD.
Results
The IVW estimates from the discovery MR analysis indicated no statistically significant causal effect of genetically predicted RNFL or GC-IPL thickness on AD or circulating total-tau levels, and reverse MR analysis found no causal link either (PIVW > 0.05). Replication bidirectional MR analysis produced consistent negative results (PIVW > 0.05). Sensitivity analyses demonstrated robustness across all MR methods, with no evidence of heterogeneity, horizontal pleiotropy, or instrumental variable outliers. Genetic colocalization analysis identified no shared causal variants between RNFL or GC-IPL thickness and AD or circulating total-tau (posterior probability H4 < 0.75).
Conclusion
Our study does not support a genetic causal link between retinal thickness, AD, and circulating total-tau levels, despite previous observational studies suggesting an association between retinal thinning and higher AD risk. Further research is needed to clarify the relationship between RNFL and GC-IPL thickness and AD, as well as the underlying biological mechanisms.
An Algorithm for Shape-Based Distance of Microseismic Time Series Waveforms and its Application in Clustering Mining Events
Authors: Luo Hao , Liu Ziyu , Ge Song , Ding Linlin , Zhang Li 
Published: January 2025

Abstract

To improve the efficiency and accuracy of microseismic event extraction from time-series data and enhance the detection of anomalous events, this paper proposes a Multi-scale Fusion Convolution and Dilated Convolutions Autoencoder (MDCAE) combined with a Constraints Shape-Based Distance algorithm incorporating volatility (CSBD-Vol). MDCAE extracts low-dimensional features from waveform signals through multi-scale fusion and dilated convolutions while introducing the concept of waveform volatility (Vol) to capture variations in microseismic waveforms. An improved Shape-Based Distance (SBD) algorithm is then employed to measure the similarity of these features. Experimental results on a microseismic dataset from the 802 working face of a mining site demonstrate that the CSBD-Vol algorithm significantly outperforms SBD, Shape-Based Distance with volatility (SBD-Vol), and Constraints Shape-Based Distance (CSBD) in classification accuracy, verifying the effectiveness of constrained time windows and volatility in enhancing performance. The proposed clustering algorithm reduces time complexity from \((O(n^2))\) to \((O(n \log n))\), achieving substantial improvements in computational efficiency. Furthermore, the MDCAE-CSBD-Vol approach achieves 87% accuracy in microseismic time-series waveform classification. These findings highlight that MDCAE-CSBD-Vol offers a novel, precise, and efficient solution for detecting anomalous events in microseismic systems, providing valuable support for accurate and high-efficiency monitoring in mining and related applications.
Effect of temporomandibular joint anterior disc displacement on condylar height in different age groups
Authors: Wu Siyu , Zhang Dahe , Xia Simo , Shen Pei , Yang Chi 
Published: January 2025

Abstract

Background:Temporomandibular joint ADD is highly prevalent and harmful, and some patients have no obvious clinical symptoms, but it can cause facial asymmetry, mandibular retrusion and other dental and maxillofacial deformities. Nevertheless, the impact of ADD on condylar height in individuals of varying age groups remains uncertain particularly with regard to condylar heights at different stages of development. The aim of this retrospective self-controlled study was to investigate the association between condylar height and temporomandibular joint anterior disc displacement (ADD) in different age groups.
Materials and Methods: Patient characteristics, condylar height, disc length, and displacement distance at the baseline (T0) and the second follow-up visit (T1) were collected, and the differences between the two-time points were analyzed.
Results: A total of 149 patients who were diagnosed with unilateral ADD were included in the study. In comparison to T0, the affected condylar height decreased 0.66 mm, whereas the non-affected condylar height increased 1.37 mm at T1. The further subgroup analysis revealed no statistically significant change in the affected condylar height of the 11-17 age group. However, a considerable reduction in height was observed on the ADD side in the subgroup above 18 years, when compared to the T0 period.
Conclusions: ADD disrupts the normal development of condylar bone and cartilage in all age groups. Clinician recognises that ADD results in condylar growth inhibition in the young and condylar resorption in the adult.
Performance of Molecular Culture ID in diagnosis of bacterial pericarditis
Authors: Bos Martine , Sánchez Maria Miguélez , Remijas Lauren , houdt robin van , peters edgar , Budding Dries 
Published: January 2025

Abstract

Bacterial pericarditis is a serious condition for which diagnosis relies on culture of the pericardial fluid. Culture often remains negative in cases of fastidious organisms or prior antibiotic treatment. To alleviate this issue, we developed Molecular Culture ID, an IVDR-approved, PCR-based pan-bacterial assay that identifies bacteria to the species level. Here, we evaluate the diagnostic accuracy of this test on a uniquely large sample set of 42 pericardial effusions. Molecular Culture ID identified 11 positive samples whereas culture detected only 7, demonstrating the promising potential of Molecular Culture ID to diagnose bacterial pericarditis.
Antibacterial Activity and Characterization of CaO Nanoparticles Synthesized from Eggshell
Authors: Maji Joyshree , Banerjee Avishek 
Published: January 2025

Introduction:
With an average crystallographic size of 8.67 nm, we studied the antibacterial
properties of CaO nanoparticles against microorganisms. The CaO NPs used in this study
were synthesized using a simple soft chemical method.

Methods:
To assess antibacterial activity, three methods were employed: the live count (LC)
method, the agar cup method, and the minimum inhibitory concentration (MIC) approach. The
CaO nanoparticles used in this study were produced using a simple soft chemical method.

Results:
TEM study revealed that the application of nanoparticles disrupted the cell walls of pathogens.

Conclusion:
We can conclude from this work that the lethal effect rises with CaO nanoparticle
concentration. According to this research, CaO NPs seem like a good option for creating novel
antibacterial drugs that are more effective against infections. The dose amount may be used in therapeutic
settings. Considering this, the application of CaO nanoparticles as antibacterial agents
could result in effective in vivo experiments.
INHIBITION OF MANGKOKAN LEAF (Nothopanax scutellarium Merr.) ETHANOL EXTRACT ON THE GROWTH OF Salmonella typhimurium BACTERIA
Authors: Sari Herninda Dhama , Octavia Bernadetta 
Published: January 2025

Typhoid fever is an infectious disease of the digestive tract caused by the bacterium Salmonella typhimurium. Mangkukan leaf (Nothopanax scutellarin Merr.) can be an alternative treatment because it contains flavonoids, saponins, tannins, and alkaloids. This study aimed to determine the ability of Mangkukan leaf extract as an antibacterial in inhibiting the growth of S. Typhimurium bacteria. This study used a factorial completely randomized design consisting of two factors, namely the concentration of the extract and the age of the inoculum with 4 repetitions. The concentration of the extract used was 5%, 10%, 20%, 40%, and 80%, equipped with the positive control (chloramphenicol), and negative control (aqua dest), while the age of the inoculum was based on the growth phase of the test bacteria, namely 3 hours, 6 hours, 18 hours. hours, and 24 hours. Antibacterial activity testing was carried out using the Disc Diffusion method (Kirby-Bauer Test). The test concentrations of 5%, 10%, 20%, 40%, and 80% test concentrations resulted in inhibition zone diameters of 3.41 mm, 5.4 mm, 6.04 mm, 7.43 mm, and 9.48 mm, respectively. The 80% concentration of ethanol extract from the kukukan leaf was effective in inhibiting the growth of S. typhimurium bacteria with an antibacterial effectiveness value of 60.81%.
Current state of grain production in the Russian Federation and promising areas of development
Authors: Suslov S. A. , Filippova O. N. 
Published: January 2025

Relevance. The Russian Federation is one of the largest grain producers in the world, demonstrating stable growth in yields, gross production and exports of grain crops in the last decade.The purpose is to analyze the current state of grain production both in the Russian Federation as a whole and in the context of its federal districts. Individual indicators are presented by the leading regions in grain production.Objectives: to study the factors that have determined the current situation in the grain sector of the country, as well as to consider the most pressing challenges and promising directions for the development of the grain industry in the country; to explore the directions of development of the grain industry, the introduction of new technologies and increasing the competitiveness of Russian grain on the world market. An important feature of the article is the study of the dynamics of grain yields and production volumes not only in recent years, but also in dynamics since 1950, which made it possible to compare the results of the current state of the industry with the pre-reform period.Methodology. The methods of quantitative and qualitative analysis, monographic and retrospective analysis, methods of comparing economic phenomena and processes, methods of abstraction, generalization of analyzed economic information are used.Results: the results of the impact of government programs to support and attract investment in the grain industry are summarized; special attention is paid to the urgent challenges of the future facing the Russian grain sector, in particular, the renewal of the material and technical base, improvement of the grain storage system and its logistics.Conclusions. The final part of the article explains the necessary directions in the development of grain production in the country, aimed at improving the production performance of the grain industry, improving the quality of grain produced and increasing export potential.
Socio-philosophical analysis of the concept of youth policy in the study of I. M. Ilyinsky "Youth and youth policy"
Authors: Ikromov U. K. 
Published: January 2025

Relevance. Modern political realities require new approaches to the political activity of young people in Russia. Igor Mikhailovich Ilyinsky in his work "Youth and Youth Policy" offers a rethinking of traditional ideas about the political activity of young people, which is of interest for research and evaluation of its effectiveness and social impact on society.The purpose is to review and analyze the main ideas and concepts presented in the work "Youth and Youth Policy" by Igor Ilyinsky for the study and understanding of youth policy in modern Russia.Objectives: to determine the relevance and significance of I. Ilyinsky's themes and ideas about youth policy in modern society; identify the key issues investigated in the monograph and assess their significance and relevance; to determine the novelty and originality of the research presented in I. Ilnsky's monograph "Youth and youth Policy"; to offer recommendations and conclusions based on the analysis of the monograph to improve the understanding and practice of youth policy.Methodology. The study was conducted on the basis of a systematic approach, such as analysis, synthesis and generalization.Results. The presented manuscript contains a socio-philosophical analysis of the concept of youth policy in the work "Youth and Youth Policy" by I. M. Ilyinsky. In the course of this study, a critical analysis of expert opinion on the state and development of youth in modern Russia was carried out.Conclusions. The conducted socio-philosophical analysis allows us to argue that in his work "Youth and youth Policy" Professor Igor Ilyinsky often focuses on traditional values and norms, attaches special importance to them in the context of youth policy, but does not take into account its needs for innovation and change, which in the future may limit the diversity of opinions and ideas among modern youth. At the same time, it should be emphasized that young people are a dynamic and active part of society, and their role in political life should be interactive and progressive, and not limited to conservative frameworks. Youth, like any other social strata, should have freedom of choice, the right to their own opinion and self-determination. The restriction of this freedom by the State or the imposition of certain standards and expectations on young people can lead to violation of individual rights and restriction of its development.
Factors, causes and ways of resolving ethnic conflicts in the Russian Federation
Authors: Vetrova O. A. , Krasilnikovа T. D. 
Published: January 2025

Relevance. In history, many countries have faced the challenge of managing a multinational community. Russia shows that diversity in itself can be both a wealth and a challenge. Ethnic conflicts in Russia have a long history and remain an urgent problem in our time.The purpose is to identify the main trends and patterns of the development of ethnic conflicts in Russia, as well as to consider various approaches to their resolution.Objectives: to analyze the main theoretical approaches to the study of ethnic conflicts; to consider the history of ethnic conflicts in Russia; to characterize the main types of ethnic conflicts in Russia; to analyze various ways of resolving ethnic conflicts in Russia.Methodology. Typological analysis was used as the methodological basis of the study (to classify ethnic conflicts in Russia) and a comprehensive analysis (to consider various ways to resolve ethnic conflicts in Russia).Results. The main results are defined as follows: within the framework of this work, an analysis of scientific sources was carried out, on the basis of which the main types of ethnic conflicts in Russia and various ways of resolving ethnic conflicts in Russia were determined.Conclusions. Based on the results of the analysis of scientific sources, the following conclusions can be drawn. Ethnic conflicts in Russia are a serious problem that needs to be addressed. The main causes of conflicts were identified as socio-economic factors (inequality in living standards, unemployment, discrimination); cultural and religious factors (differences in languages, traditions, customs); political factors (power struggle, infringement of the rights of national minorities). To prevent and resolve ethnic conflicts in Russia, it is necessary to take into account various historical, social, political and psychological factors.