bluuebunny/crossref_metadata_2025_split huggingface dataset:
Monastères féminins, vie économique et culture matérielle au haut Moyen Âge (VIe-Xe siècle) : un aperçu sur le cas italien
Authors: Destefanis Eleonora 
Published: November 2023

L’article s’intéresse à la vie économique des monastères féminins dans le contexte italien. Ceux du VIe siècle sont connus grâce aux écrits de Grégoire le Grand. Mais la situation floue et souvent instable de la dotation patrimoniale de ces premiers monastères
évolue considérablement après la conquête lombarde et celle des Carolingiens, ce qui correspond aussi à un moment où la documentation devient plus abondante et détaillée. Les monastères féminins profitent alors pleinement du soutien de la royauté et de l’aristocratie, elles-mêmes impliquées dans les fondations, qui octroient aux moniales des patrimoines parfois très étendus. Les formes de gestion ne semblent pas différentes de celles mises en place dans les monastères masculins, issus d’ailleurs du même milieu social. Mais en dehors de ces grands monastères royaux, il semble que les biens des communautés féminines se développent sur des territoires plus restreints. Les activités artisanales y sont très répandues, que ce soit sur les propriétés plus ou moins proches du monastère ou au sein même de l’établissement, comme en témoigne le cas de Saint-Sauveur de Brescia. L’activité textile y apparaît en particulier comme un secteur privilégié occupant l’attention des moniales.
Informatization of a Centralized Clinical Diagnostic Laboratory: Experience in Implementing a Laboratory-Information System in the Brest Regional Clinical Hospital
Authors: Калина А.С. , Матулис Г.И. , Кабецкая И.В. , Шахрай Ю.Л. 
Published: November 2023

Глобализация, повсеместное развитие информационных систем и их интеграция во все сферы экономики требуют широкомасштабных изменений, в том числе и в области медицины. С попытками автоматизировать и облегчить рабочий процесс медицинского персонала возникает потребность в использовании специализированных информационных систем. В статье представлена информация об особенностях апробированной лабораторной информационной системы и предоставляемых ею широких возможностях совершенствования деятельности клинико-диагностических лабораторий, а также отражен опыт автоматизации крупнейшей в Брестской области централизованной клинико-диагностической лаборатории учреждения здравоохранения «Брестская областная клиническая больница», связанный с использованием лабораторно-информационной системы. Уделено внимание тем задачам, которые ставились перед разработчиками системы, а также принципам и критериям выбора информационной системы с учетом открываемых ею новых возможностей деятельности лаборатории после внедрения в медицинскую практику, а также возможностям, которые приобрела лаборатория после внедрения.
Globalization, the widespread development of information systems and their integration in all areas of the economy require large-scale changes, including in the medical field. With attempts to automate and facilitate workflow for medical personnel, it is necessary to use specialized information systems. This article will consider the capabilities and features of the laboratory information system, as well as the experience of automating the largest centralized clinical diagnostic laboratory in the Brest region – Brest Regional Clinical Hospital using the laboratory information system. Also, attention is paid to the tasks that were set for the developers, the principles and criteria for choosing an information system, as well as the opportunities that the laboratory acquired after implementation.
Intravascular Treatment of Extracranial Internal Carotid Artery Dissection
Authors: Efimov V. V. , Fedorchenko A. N. , Beliy A. I. , Suslov E. S. 
Published: November 2023

Objective: To evaluate the efficacy and safety of endovascular treatment of extracranial dissection of the internal carotid artery, as well as pseudoaneurysm associated with dissection.Clinical cases: In this article we report the results of endovascular treatment of 2 patients with iatrogenic and spontaneous dissection of the cervical segment of the internal carotid artery.Conclusions: Internal carotid artery dissection can lead to significant narrowing of the vessel lumen, occlusion or pseudoaneurysm followed by hemodynamic or embolic stroke despite anticoagulant therapy. In some cases, endovascular stenting for dissection is a safe and effective method of restoring vessel lumen integrity with a good clinical outcome.
Treatment Outcomes in STEMI Patients With No/Slow-Reflow Phenomenon, Depending on Age
Authors: Sazanov G. V. , Shugushev Z. Kh. , Belokon O. S. , Ermakov S. V. , Mukovnikova A. V. 
Published: November 2023

Objective: To assess the risks of no/slow-­reflow phenomena and treatment outcomes in patients with ST­-segment elevation myocardial infarction (STEMI) from different age groups.Materials and methods: We analyzed treatment outcomes of 535 STEMI patients who were divided into 4 groups based on their age: 33 patients younger than 44 years (group 1), 209 patients aged 45 to 59 years (group 2), 247 patients aged 60 to 74 years (group 3), and 46 patients aged 75 to 80 years (group 4).Results: Our study revealed that among the young people STEMI is more often found in men, whereas in the older population the number of women increases accounting for 37% (compare with 3% among the young patients). It was also shown that with age, statistically significantly more coronary stents (P = .009, Kruskal­Wallis test) are needed to repair an infarct-­related coronary artery lesion. The time required to perform a percutaneous coronary intervention was statistically significantly higher in the older adults than in the young patients (P = .022, Kruskal­-Wallis test).Conclusions: Our study found that the frequency of deaths was higher in STEMI patients from the older age groups (9.30% and 10.90%), whereas in the young patients, no deaths were registered during the 30­-day follow­up. In the middle­aged patients, mortality accounted for 3.3%. The reported differences were statistically significant (P = .016, Pearson’s χ2). The analysis of overall survival based on the age group revealed statistically significant differences (likelihood ratio test, P = .006).
Options to Determine the Time for Conversion Osteosynthesis in Patients With Multiple Trauma
Authors: Mukhanov M. L. , Blazhenko A. N. , Baryshev A. G. , Seumyan E. V. , Blazhenko A. A. , Khrustaleva Yu. O. 
Published: November 2023

Objective: To reduce the complication rate in patients with multiple trauma (including bone fractures) by objectifying criteria that allow conversion from the external fixator to the definitive osteosynthesis.Materials and methods: The study was based on a retrospective analysis of the treatment outcomes in 308 patients (18­60 years, males and females) with multiple trauma and no apparent comorbidity.All patients were divided into 3 groups depending on the treatment outcomes. The therapeutic and diagnostic approaches in both groups were equal and compliant with the current standards and guidelines. Surgical treatment was performed according to the damage control principles in orthopedics.As the groups were statistically comparable, their data could be used for an accurate comparative statistical analysis.Results: The statistical analysis of the treatment outcomes in patients from all the groups demonstrated the possibility of using the SOFA scale to determine the conversion time. In patients who underwent conversion osteosynthesis, with comparable severity of injuries according to the NISS scale, a SOFA score >10 points right prior to the surgery was associated with the maximum number of complications including mortality. A SOFA score <6 points right prior to the surgery was associated with significantly lower number of complications and no mortality.Conclusions: Objective tools for assessing the severity of the condition, such as the SOFA scale, will allow to customize the approach to the time of conversion osteosynthesis in patients with multiple trauma and improve the treatment outcomes in general.
Survival of Patients With Primary Cutaneous Melanoma and the Surgical Treatment Option Based on the Level of the Surface Protein PD-L1 in the Tumor Tissue
Authors: Yargunin S. S. , Reshetov I. V. , Shoykhet Ya. N. , Samoylova S. I. , Chukhrai O. Yu. , Pyatakov S. N. 
Published: November 2023

Background: The PD-­L1 level is mainly used to predict the effect of drug treatment in patients with melanoma. Despite the radical nature of surgery in these patients, the rate of disease progression remains high. Therefore, it is important to study the relation between the PD-­L1 level in the tumor and surgical treatment options for cutaneous melanoma and patient survival.Objective: To analyze the effect of the PD-­L1 level in patients with primary cutaneous melanoma at different levels of tumor excision and options for closing the surgical defect.Materials and methods: We used data of 143 patients with stage 0­IIIC primary cutaneous melanoma who were randomized into 2 groups: the main group (wide excision of the tumor and plastic repair of the tissue defect) and the comparison group (standard tumor removal) with different PD-­L1 levels (IC [immune cells] %). The 5­-year survival of patients was estimated.Results: We found the mutual dependence of the PD­-L1 level and the survival of patients with stage 0-­IIC melanoma on the extent of the tissues removed and the option for closing the defect.Conclusions: The 5­year progression­free survival in patients with stage 0­IIA primary cutaneous melanoma was higher than that of those with stage IIB-­IIC melanoma regardless of the PD-­L1 level. In patients with stage 0-­IIA primary cutaneous melanoma and the low PD-­L1 level (˂5), progression­free survival was 26.3% higher (P = .013) than that of those with the high PD-­L1 level (≥5). In patients from the main group with stage 0-­IIA melanoma and the low PD­L1 level (˂5), progression­free survival was 25% higher (P = .017) and overall survival was 16.7% higher (P = .045) compared with patients from the control group with the same PD-­L1 level. In patients from the main group with stage 0­-IIC melanoma and the high PD­-L1 level (≥5), the 5-­year progression­free survival was 21.2% higher (P = .033) compared with patients from the comparison group.
Congenital Heart Diseases: Risk Factors and Ultrasound Diagnostic Potential at the First Screening
Authors: Pomortsev A. V. , Karakhalis M. N. , Matulevich S. A. , Daschyan G. A. , Khalafyan A. A. , Sencha A.  N. 
Published: November 2023

Introduction: Due to the high incidence of congenital heart diseases (CHD) it is important to identify risk factors for abnormal organogenesis. There is a crucial medical need to understand cardiogenesis and possible markers of abnormalities in fetuses.Objective: To determine risk factors for CHD in pregnant women and their partners and assess CHD markers on the first ultrasound screening.Materials and methods: We analyzed 221 medical records of pregnant women with prenatally diagnosed fetal CHD and divided the patients into 2 groups: group I (n = 177) with CHD compatible with postnatal development and group II (n = 44) with CHD incompatible with postanatal development. We evaluated physical findings and somatic and reproductive history in both groups. We retrospectively analyzed 2272 ultrasound scans and first screening markers: nuchal translucency (NT) thickness and ductus venosus pulsatility index (DVPI).Results: We identified possible risk factors for fetal CHD: body mass index, P = .000; age of menarche, P = .037; chronic tonsillitis, Р = .046; cervical erosion, Р = .045; vulvovaginal candidiasis, Р = .005; vaginitis, Р = .027; cervicitis, Р = .027; chronic hepatitis B and C viruses, Р = .005; respiratory tract infection with fever during the current pregnancy, Р = .012. We built 500 networks with the highest performance for a predictive model and found that the model’s predictors did not fully represent the risk factors for CHD. CHD with increased NT thickness (≥2.5 mm) was detected in 2.24% of cases. NT thickness and DVPI were 3.37 ± 0.92 mm and 1.098 ± 0.158, respectively. According to our correlation analysis, increased DVPI and NT thickness were associated with CHD (R = 0.510).Conclusions: It is not possible to identify risk factors for CHD in fetuses by medical history, reproductive history and physical status of pregnant women, and unhealthy habits of their sexual partners. Increased NT thickness and DVPI moderately correlate with CHD incidence.
Comparison of Cardioprotective Effects of Dapagliflozin and Trimetazidine in the Model of Doxorubicin-Cyclophosphamide Cardiotoxicity
Authors: Avagimyan A. A. , Trofimenko A. I. , Sheibani M. , Kakturskiy L. V. , Urazova O. I. , Navasardyan G. A. , Jndoyan Z. T. , Sulashvili N. V. , Gabunia L. I. , Gorgaslidze N. S. , Khamidova F. M. , Martemyanova L. A. , Pogosova N. V. , Sarrafzadegan N. 
Published: November 2023

Background: Data published by task groups of the Ministry of Health of the Russian Federation, the European Society of Cardiology, and other medical associations and institutions show that chemotherapy-induced cardiomyopathy is still a challenging issue that requires further research.Objective: To compare the cardioprotective potential of trimetazidine and dapagliflozin in a rat model of doxorubicin-cyclophospha-mide cardiomyopathy.Materials and methods: Our randomized in vivo experimental study included 80 Wistar female rats. Doxorubicin and cyclophosphamide were administered at a dose of 15 mg/kg and 150 mg/kg, respectively. Trimetazidine (42 mg/kg) and dapagliflozin (14 mg/kg) were additionally administered to groups 3 and 4, respectively. The total duration of the experiment was 14 days.Results: Doxorubicin+cyclophosphamide mode of chemotherapy induces the development of toxic-ischemic cardiomyopathy. The trimetazidine and dapagliflozin administration was accompanied by stabilization of cardiovascular parameters. Comparison of both drugs’ cardioprotective properties revealed a clear advantage of dapagliflozin over trimetazidine, especially in terms of such an important indicator as N-terminal pro-B-type natriuretic peptide.Conclusions: Further research aimed at exploring the cardioprotective potential of dapagliflozin against cardiovascular complications of chemotherapy is justified from a pathogenetic point of view.
Model for Predicting the Risk of Bronchopleural Fistula After Pneumonectomy for Destructive Pulmonary Tuberculosis
Authors: Serezvin I. S. , Avetisyan A. O. , Potievskiy M. B. , Rodin A. A. , Rodin N. A. , Savon G. K. , Grabetskii D. K. , Yablonskiy P. K. 
Published: November 2023

Introduction: Predicting various events based on influencing factors is important for statistical analysis in medical research. Unfortunately, mathematical models are rarely built on the identified factors.Objective: To develop a model to predict the risk of bronchopleural fistula after pneumonectomy for destructive pulmonary tuberculosis.Materials and methods: We analyzed medical records of 198 patients who underwent pneumonectomy. Of them 6 patients (3%) developed a bronchopleural fistula. We used machine learning algorithms such as ridge regression, support vector machine, random forest, and CatBoost, the Jupyter open­source development environment, and Python 3.6 to build prediction models. ROC analysis was used to evaluate the quality of the binary classification.Results: We built 4 models to predict the risk of bronchopleural fistula. Their ROC AUC were as follows: ridge regression – 0.88, support vector machine – 0.87, CatBoost – 0.75, and random forest – 0.74. The model based on the ridge regression showed the best ROC AUC. Based on the coordinates of the ROC curve, the threshold value of 1.9% provides the maximum total sensitivity and specificity (100% and 68.8%, respectively).Conclusions: The developed model has a high predictive ability, which allows focusing on the patient group with an increased risk of bronchopleural fistula and justifying the need for preventive measures.
Evaluation of the Fixation Method and the Intraperitoneal Mesh Location Effect on Adhesion Formation, Deformation, and Shrinkage of the Mesh in Large Animals
Authors: Armashov V. P. , Belousov A. M. , Potapov P. А. , Matveev N. L. 
Published: November 2023

Background: The quality of mesh integration and adhesion formation in the intraperitoneal onlay mesh hernia repair (IPOM) is considered to depend not only on the mesh structure but also on a complex of other factors. This study aims to evaluate the correlation between the adhesion formation, mesh deformation, and shrinkage on the fixation method and the mesh location in the abdominal cavity.Materials and methods: During laparoscopy (IPOM), 6 different meshes (2 each in the epi-, meso-, and hypogastric regions) were installed in the intraperitoneal position in each of 3 pigs. For mesh fixation, absorbable poly-D, L-lactide or non-absorbable stainless steel and polyetheretherketone (PEEK) tacks were randomly selected. Relaparoscopy was performed after 45 days, autopsy after 90 days. The results were calculated for meshes with absorbable and non-absorbable tacks and for meshes placed in the epi-, meso-, and hypogastrium.Results: The fixation methods did not significantly affect the deformation and shrinkage of the mesh. Absorbable tacks were associated with higher adhesion formation for most indicators at all stages of the study. The difference between absorbable and non-absorbable fixation reached a maximum by day 90, when the number of mesh pieces with adhesions was 66.7% vs 11.1% (P = .05), and the adhesion scores were 5 (0-6) vs 0 (0-0) (P = .01). The mesh location on the abdominal wall did not significantly affect its deformation and shrinkage. At the same time, most of the adhesion indicators depended on the mesh location. Starting from hypogastrium, the extent and the type of adhesions increased and were maximal in epigastrium. The greatest difference between the epi-, meso-, and hypogastrium was noted by day 45, when the number of mesh pieces with adhesions was 100%, 50%, and 16.7% (P = .014), and the adhesion scores were 6 (5-7), 2 (0-4), and 0 (0-0) (P = .007).Conclusions: The fixation method and the intraperitoneal mesh location do not affect its deformation and shrinkage but significantly affect the adhesion formation.
WILL NOVEL EDUCATION POLICY STIMULATE BUSINESS MANAGEMENT OPPORTUNITIES IN BANGLADESH: A CRITICAL ANALYSIS AND LESSONS TO BE LEARNED FROM THE UNITED STATES
Authors: Jowarder Mohaimenul Islam 
Published: November 2023

The purpose of this study is to understand how the novel education policy, which is to be implemented in 2025 in Bangladesh, will foster business management opportunities and the probable lessons from the United States. This study conducted a mixed methodology analysis followed by a purposive sampling method. 200 students from primary to higher secondary levels and 20 teachers were selected. We also conducted Four Focus Group Discussions with curriculum experts who were directly involved with developing this method in Bangladesh. An exclusive interview with the President of Hyundai Motors Asia assisted in exploring the context in-depth. The study revealed a positive response from students, ranging from prospective career opportunities to rising interests to implement their acquired knowledge, eradicating the fear of science as well as emphasizing becoming small business entrepreneurs and believing in stimulating business opportunities. Further research is encouraged to assess the impacts of this educational reform in diverse employment sectors in-depth.
Keywords: Education Policy; Business Management; Bangladesh; United States
PENGARUH UKURAN PERUSAHAAN DAN FINANCIAL DISTRESS TERHADAP NILAI PERUSAHAAN PADA PERUSAHAAN PERBANKAN KONVENSIONAL YANG TERDAFTAR DI BURSA EFEK INDONESIA
Authors: Juniarsi Marlisa , Kalsum Ummi , Yamaly Fadhil 
Published: November 2023

This study aims to determine whether there is an effect of firm size and financial distress on firm value. This research includes this type of associative research. The research population is conventional banking companies listed on the Indonesia Stock Exchange for the 2017–2021 period, a total of 42 companies. The sample in this study was 12 companies with a total of 60 observational data points, using a purposive sampling technique. The data used in this research is secondary data. The analysis technique used is quantitative, with multiple linear regression analysis techniques. The partial test results show that there is a significant effect of firm size on firm value, and there is a significant effect of financial distress on firm value.
Keywords: Company Value; Company Size; Financial Distress
THE SOLIDARITY ECONOMY OF MARGINALIZED COMMUNITIES IN SOUTH AFRICA: AN ANALYSIS OF BUYING AND SAVINGS CLUBS IN GQEBERHA
Authors: Hlatshwayo Mondli , Dloto Anele , Mutekwe Paddington 
Published: November 2023

Like other parts of the world, South Africa has been seriously affected by the economic recession that has brought unemployment and poverty to large numbers of people in many regions of the world. The districts of Zwide and Kwazakhele are parts of Nelson Mandela Bay, in the Eastern Cape province of South Africa, and are homes to working-class households that suffer extreme hardship due to poor socioeconomic conditions. They are excluded from participation in the mainstream economy and have no sustainable means of supporting their families. By forming buying clubs and savings, these communities try to alleviate their hardship. Data was collected through semi-structured interviews to gather the views and experiences of members of the buying and saving clubs. In investigating these clubs, this paper raises the possibility that these community initiatives could indicate the beginnings of a solidarity economy and the possibility of creating a more just and inclusive society in an environment characterized by unemployment, hunger, and poverty. The research offers insights into the lives of nineteen women and one man, residents of the two marginalized communities, and their agency in alleviating poverty and bringing about change in their lives through the implementation of a buying club and a savings club.
Keywords: Solidarity Economy; Poverty; Marginalized Communities; Communal Work; Livelihoods; Stokvel; Bulk Buying
BELANJA DESA SEBAGAI DETERMINAN INDEKS PEMBANGUNAN MANUSIA PADA 21 KABUPATEN DI PROVINSI NUSA TENGGARA TIMUR
Authors: Edon Putra Arismunandar , Perseveranda M E , Manafe Henny A 
Published: November 2023

The objective of this study is to analyze the influence of village expenditure on the Human Development Index in 21 districts in East Nusa Tenggara Province. This is secondary data obtained from the official website of the Statistics Center Bureau (BPS), which contains all reports of income realization and expenditures of the village government in 21 districts in East Nusa Tenggara Province from 2017 to 2020. The methods of analysis used in this study are descriptive analysis and panel data analysis. Results show that, simultaneously, village government expenditures, community development expenditures, and capital expenditures positively and significantly influence the human development index. Partially, village government expenditures negatively and significantly influence the Human Development Index. Community development expenditures and capital expenditures positively and significantly influence the Human Development Index.
Keywords: Village Government Expenditures; Community Development Expenditures; Capital Expenditures; Human Development Index