bluuebunny/crossref_metadata_2025_split huggingface dataset:
Safety, Efficacy and Persistence of Advanced Therapies in Inflammatory Bowel Disease: Results from ORIGINS. A Retrospective Observational Study
Authors: Mateescu Radu Bogdan , Gheorghe Cristian , Trifan Anca Victorita , Saftoiu Adrian , Seicean Andrada , Diculescu Mihai Mircea , Banciu Christian , Gheorghe Liliana Simona , Busuioc Bogdan , Goldis Adrian , Dobru Daniela , Fratila Ovidiu , Eugen Dumitru , Bataga Simona , Constantinescu Gabriel , Gheonea Dan , Tantau Alina , Jinga Mariana , Brisc Ciprian , Cijevschi Prelipcean Cristina , Chira Romeo , Fierbințeanu-Braticevici Carmen , Dumitrascu Dan , State Monica , Voiosu Theodor , Negreanu Lucian 
Published: December 2023

Background and Aims: Real-world assessments of efficacy and safety of advanced therapies used for inflammatory bowel disease (IBD) patients are limited. We aimed to report safety, efficacy and treatment persistence of new molecules (infliximab, adalimumab, vedolizumab, tofacitinib, ustekinumab) in a retrospective multicentric national Romanian analysis.
Methods: We conducted a nationwide, retrospective observational multicentric study. Data were collected retrospectively from electronic and paper files. Patients who started on one of the five investigated molecules during December 2019-December 2021 were included. The main outcome measures were clinical remission, endoscopic healing, persistence on treatment and safety data.
Results: A total of 678 adult patients from 24 Romanian IBD centers with a diagnosis of ulcerative colitis or Crohn’s disease were included. Participants had previously failure to one (268, 39.5%), two (108, 15%) or more treatment lines and only 38% (259) were biologic naïve. In the 24 months study period, most patients were started on vedolizumab (192, 28%), followed by adalimumab, infliximab, ustekinumab and tofacitinib. In biologic-naïve patients, most physicians (72%) preferred anti-TNF treatment as first line biologic (93 patients started on infliximab, 92 on adalimumab), followed by vedolizumab, ustekinumab and tofacitinib. During follow-up, 71% (470, p=0.05) of patients achieved clinical remission and 36% (134, p=0.03) achieved mucosal healing. The 6 months milestone for persistence was reached in 78% (530) of cases. Almost half of patients (47%, 316 patients) persisted on their current treatment for over 12 months. Overall, an adverse reaction was reported for 67 (10.4%) patients, with no lethal events.
Conclusions: Population of biologic-experienced IBD patients in Romania is increasing and is becoming more difficult to achieve long-term disease control. Discontinuation rates for advanced therapies are high.
SUFISM AND ECONOMIC RESILIENCE: TRAJECTORY OF TAREKAT NAQSYABANDIYAH-KHALIDIYAH BABUSSALAM (TNKB)
Authors: Hidayat Ziaulhaq 
Published: December 2023

This article provides updated information on the tarekat following the entrepreneurial bankruptcy in the Tarekat Naqsybandiyah-Khalidiyah Babussalam (TNKB). This study charts the TNKB trend regarding the spiritual institution’s economic toughness. This research asks how TNKB will be able to continue operating if its founder no again walks away from entrepreneurs and what other economies may emerge in his place. Findings from the study show that the entrepreneurial bankruptcy of TNKB entrepreneurs is strongly tied to the conflict of the leader, which is exacerbated by Tuan Guru’s need to concentrate on other issues. Uang salam originated as a substitute for a new economic source to preserve the TNKB. Uang salam is a practice that persists until it eventually makes room for commodification. Commodification is a tactic used by TNKB as part of its survival plan after the entrepreneurial bankruptcy so that it can continue to exist and advance up to the present.
Khiṭāb ‘Ilm Al-Nafs Al-Ṣūfī: Tatabbu' Al-Judhūr Wa Al-Naẓariyyāt Wa Al-Taṭbīqāt
Authors: Ahmadi Rizqa , Badruzaman Abad 
Published: December 2023

Sufi Psychology studies continue to be explored for the sake of scientific independence. The inhibiting factor of this study is the differences in terms of paradigmatic characters of the two disciplines. The Psychology that tends towards empirical-positivism is different from Sufism which tends to be subjective-personal. However, this fact did not reduce the efforts of the scholars to build a bridge between of the two. Recent psychology studies have placed spirituality as an important element so that the Transpersonal Psychology and Humanistic Psychology schools emerged. Likewise, contemporary Sufism studies are increasingly contextual to various socio-cultural problems and are not limited to the study of the doctrines and teachings of rigorous Sufi orders. Through a literature review that is presented descriptively with a historical-thematic approach, this paper presents Sufi Psychology as a synthesis between the two disciplines. Substantially, Sufi psychology has existed in early Islamic tradition. The nature of Sufi psychology is also scattered in the Sufi tradition that developed in the 3rd and 4th centuries of Hijriyah. As for the epistemic formula, the term Sufi Psychology can be found in the studies of Javad Nur Bakhsy, Robert Frager, Amir Najjar, and Lynn Wilcox. The theme of heart, self, and soul is the main topic of this study. In practical terms, theories of Sufi Psychology can complement findings that have not been widely disclosed in psychology, especially regarding psychiatric symptoms that are observed not only from behavioral assessments, as well as their relationship to transcendent elements.
Estimation of Fishing Ground Based on Distribution of Fishing Vessels and Oceanographic Factors in WPPNRI 573
Authors: Panggabean Donwill , Sudarmo Agnes Puspitasari , Anwar Kasful , Jalil Jalil , Nazzla Rauzatul 
Published: December 2023

Fisheries Management Area of Republic of Indonesia (FMARI) 573 has great potential and needs to be supported by complete and accurate information, especially fishing ground locations so that the fisheries sector can become better. This study aims to estimate the location of the fishing ground in the western of FMARI 573 based on the movement of fishing vessels carrying out fishing operations, as well as sea surface temperature (SST) conditions and chlorophyll-a concentrations. The data used is a 10 year time series of AQUA-MODIS and SNPP-VIIRS satellite images. Analysis of chlorophyll-a and SST using ArcGis, while estimation of fishing ground locations with overlay techniques between ship distribution with SST conditions and chlorophyll-a concentrations. The results showed that the average SST value was relatively higher during Transitional Season I compared to the other three seasons. The average seasonal chlorophyll-a concentration fluctuates, the maximum value occurs in the Western Season and the minimum in the East Season. The concentration and distribution of fishing vessels indicate fishing ground areas in Pangandaran waters and along the coast of Binuangeun waters and Palabuhan Ratu Bay.
<i>Aztec Antichrist: Performing the Apocalypse in Early Colonial Mexico</i>. By Ben Leeming
Authors: De la Cruz Abelardo 
Published: December 2023

Aztec Antichrist: Performing the Apocalypse in Early Colonial Mexico. By Ben Leeming. 2022. Denver: University Press of Colorado/Albany, NY: Institute for Mesoamerican Studies. 314pp. $100 (hardcover), $35.95 (paperback), $29.95 (e-book).
In vitro regeneration, transplantation and phytochemical profiles of Kaempferia angustifolia Roscoe
Authors: SAENSOUK Surapon , YAOWACHAI Wipa , CHUMROENPHAT Theeraphan , NONTHALEE Sukanya , SAENSOUK Piyaporn 
Published: December 2023

Kaempferia angustifolia Roscoe is a medicinal plant in the family Zingiberaceae, with wild occurrence decreasing as a result of both natural and human threats. Tissue culture techniques provide an alternative method of propagation for mass production. Microshoots of K. angustifolia (1 cm in length) were cultured on MS medium supplemented with various concentrations of cytokinins (BA and Kinetin) and auxins (NAA and IAA) for 8 weeks. Phytochemical profiles were evaluated by total phenolic contents (TPC), total flavonoid contents (TFC), antioxidant activity (2,2-Diphenyl-1-picrylhydrazyl (DPPH) and ferric reducing ⁄ antioxidant power (FRAP) assay) and Gas chromatography–mass spectrometry (GC–MS) analysis. Maximum number of shoots was observed in medium supplemented with 2 mg/l BA plus 0.5 mg/l NAA (6.33 shoots/explant) and optimal rooting was induced in MS medium with 2 mg/l Kinetin plus 1 mg/l NAA (35.70 roots/explant). Highest numbers of shoots and roots were obtained when cultured on liquid MS medium supplemented with 2 mg/l BA, 2 mg/l Kinetin and 1 mg/l NAA (8.73 shoots/explant and 29.67 roots/explant, respectively). Regenerated plantlets of K. angustifolia were transferred to pots containing different types of plant materials under natural conditions for 8 weeks. Optimal survival rate was 100% when transplanting K. angustifolia to soil, sand, soil and sand (1:1) or soil and small pieces of rock (1:1) ratio. The methanol extract of leaves K. angustifolia from natural plants and in vitro derives plants showed a significantly higher amount of TFC and antioxidant activity. GC-MS analysis identified 52 phytochemical compounds in leaves of K. angustifolia. This study may be helpful to increase the value of commercial production of K. angustifolia, pharmaceutical and medicinal purpose.
NUEVA METODOLOGÍA DE AYUDA DIAGNÓSTICA DE LA DINÁMICA GEOMÉTRICA CARDIACA. DINÁMICA CARDIACA CAÓTICA DEL HOLTER
Authors: Rodríguez Javier , Prieto Signed , Bernal Pedro , Soracipa Yolanda , Salazar Gabriel , Isaza Daniel , Cruz Luis Eduardo , Correa Catalina 
Published: December 2023

Por medio de la teoría de los sistemas dinámicos es posible cuantificar el estado y la evolución de sistemas dinámicos; la dinámica caótica cardiaca ha sido evaluada desde la teoría de sistemas dinámicos y la geometría fractal realizando investigaciones clínicas con infarto agudo de miocardio y, por otro lado, con la ley de la entropía desarrollando un diagnóstico de aplicación clínica.
Se seleccionaron 150 holters, 50 diagnosticados dentro de los límites de normalidad, 50 con infarto agudo de miocardio según diagnóstico clínico convencional y 50 diagnosticados con otras enfermedades. para cada paciente se generó la secuencia de valores de la frecuencia cardiaca, se construyó el atractor y se aplicó la metodología de box-counting para calcular la dimensión fractal, comparando los espacios de ocupación. finalmente se evaluó la sensibilidad, especificidad y el coeficiente kappa de la evaluación físico-matemática para los pacientes con infarto agudo de miocardio y normales frente al gold-standard.
Las dimensiones fractales de los atractores oscilaron entre 1,4232 y 2,0000. el número de espacios ocupados con la primera rejilla (5 lat/min) para los 150 atractores osciló entre 33 y 699; para la segunda rejilla (10 lat/min), entre 9 y 190. todos los pacientes diagnosticados con infarto agudo de miocardio se encontraron fuera de los límites de los valores para los pacientes diagnosticados dentro de los límites de normalidad, los valores de especificidad y sensibilidad fueron de 100%, y el del coeficiente kappa de 1.
Los atractores caóticos cardiacos revelan un orden geométrico que cuantifica la dinámica a través de los espacios de ocupación del fractal, diferenciando pacientes dentro de los límites de normalidad y con enfermedad aguda, con lo que se puede deducir la evolución entre estos dos estados, haciendo útil esta metodología para evaluar clínicamente dicha evolución.
IDENTIFICANDO EL INFLATÓN CON EL BOSÓN DE HIGGS DEL MODELO ESTÁNDAR
Authors: Peralta César D. , Rodríguez Yeinzon 
Published: December 2023

En este artículo, se estudia la posibilidad de que el bosón de Higgs del Modelo Estándar de Partículas Elementales pueda generar inflación primordial del tipo rodadura lenta, lo que resolvería los problemas clásicos de la cosmología estándar. El requisito crucial para hacer viable esta posibilidad, es que el campo escalar de Higgs presente un tipo particular de acoplamiento no mínimo a la gravedad. Se realiza una transformación conforme desde el marco de Jordan al marco de Einstein encontrándose una modificación al tradicional potencial de Higgs para valores muy grandes del campo, lo que permite una zona de alta planitud y, por ende, inflación primordial del tipo rodadura lenta. Se comparan los resultados asociados al índice espectral y a la razón tensor a escalar con las cotas observacionales más recientes, encontrándose que la generación de estructuras a gran escala en este escenario es satisfactoria.
HISTORIA GEOLÓGICA DEL BOSQUE HÚMEDO NEOTROPICAL
Authors: Jaramillo Carlos 
Published: December 2023

El origen y desarrollo de los bosques bajos neotropicales es aún un misterio. Hoy en dia son dominados por angiospermas, las cuales aparecen a principios del Cretácico (~140 Ma). Durante el Cretácico, sin embargo, los bosques tropicales eran dominados por gimnospermas y helechos, no eran multiestratificados, y poseían un bajo potencial fotosintético. La caida de un meteorito hace 65 Ma, transformó las comunidades vegetales neotropicales. Los bosques que se desarrollaron después del evento del meteorito eran multiestratificados, con un dosel dominado por angiospermas y alto potencial fotosintético. El clima tropical ha variado con calentamientos y enfriamientos pronunciados durante los últimos 60 Ma. La diversidad del bosque ha aumentado con los calentamientos, y se ha reducido con los enfriamientos. En los últimos 10 Ma se ha producido la fuerte expansión las sabanas. El registro fósil sugiere que las plantas modernas ya poseen la variabilidad genética necesaria para responder a incrementos de temperatura y CO2 en el ambiente.
ELEMENTARY ABELIAN P-EXTENSIONS AND CURVES WITH MANY POINTS
Authors: Garzón R. Alvaro , Teherán Herrera Arnoldo 
Published: December 2023

In the paper we give a generalization of two results of two results obtained by García and Stichtenoth ([G-S]) and use them of exhibit a method to construct curves over finite fields whose number of rational points is large compared to their genus. Such curves are induced by algebraic functions fields obtained from elementary abelain p-extensions of the rational function field Fq(x) using the trace operator TrFq/Fp.
DINÁMICA DEL PROTÓN EN MATERIA CONDENSADA: POLÍMEROS Y CRISTALES IÓNICOS
Authors: Vargas Rubén A. 
Published: December 2023

Usando medidas de espectroscopia de impedancias en el rango de las radiofrecuencias en dos tipos de conductores protónicos con estructuras desordenadas, cristales iónicos con enlaces de hidrógeno desordenados (MH2PO4, M = NH4, K) y polímeros sólidos basados en poli alcohol de vinilo (PVOH), se ha investigado la dinámica de protones. Se encuentra que obedecen a similares características en los espectros de la conductividad, permitividad y módulo eléctrico complejos. En efecto, muestran una activación térmica de la conductividad tipo Arrhenius; sus conductividades son descritas a altas frecuencias (ω/2
The Court of Justice of the European Union on Ethnic and Racial Discrimination: An Analysis of the Application of Directive 2000/43/EC
Authors: Hernández Moreno Nacho 
Published: December 2023

Xenophobia, racism, and the resulting discrimination in practice hinder the path towards achieving regulated equality and the prohibition of discrimination, aiming for a society where all individuals can enjoy substantial equality. Specifically, Directive 2000/43/EC was developed within the framework of the European Community to protect migrants and individuals belonging to ethnic minorities who are more likely to be victims of such discriminatory acts and may find themselves in a situation of greater vulnerability due to structural circumstances.This study examines the various areas of application of the Directive that have been addressed judicially by the Court of Justice of the European Union. To accomplish this, a critical analysis is conducted of the limited number of pronouncements despite more than two decades having passed since the Directive’s entry into force.Received: 22 May 2023 Accepted: 18 November 2023
Abadias Selma, Alfredo, El derecho penal frente a la discriminación laboral algorítmica, Aranzadi, Pamplona, 2023, 140 pp., ISBN 978-84-1124-618-7
Authors: Maldonado Smith Mario Eduardo 
Published: December 2023

En un pasaje ya clásico de Lewis Carroll, Alicia pregunta al Gato de Chesire por qué camino ha de andar a lo que este le responde con un nuevo cuestionamiento de ¿A dónde quieres ir? Para Alicia la respuesta no es importante por lo que el gato responde que en consecuencia tampoco es trascendente el camino que elija. En El derecho penal frente a la discriminación laboral algorítmica del Dr. Alfredo Abadías se expresa «Nos encontramos en una sociedad cambiante, que fluctúa, que navega sin un claro norte por la creciente incertidumbre y la falta de seguridad».
EFAW: a new mining attack model combining FAW attacks with the Eclipse attack
Authors: Wang Jing , Wang Zihao 
Published: December 2023

Aim
The Proof-of-Work consensus mechanism is the core mechanism of the blockchain, but the existing Fork After Withholding (FAW) attack can earn more rewards by launching attacks on the mining pools under the Proof-of-Work consensus mechanism. This paper proposes a new attack model based on the FAW attack, which further increases the attacker’s reward to explore the impact of the attack method on the blockchain network and the losses caused by the attack, which is helpful for maintaining the blockchain.
Methods
This paper proposes a new mining attack model called the "Eclipse Fork After Withholding (EFAW) attack" by combining FAW attacks with the eclipse attack. In the EFAW attack, the attacker infiltrates the victim pool by dispatching infiltrator miners. At the same time, they isolate a portion of miners in the victim pool through eclipse attacks, intercepting the valid information transmitted by these isolated miners. The attacker selectively discards or strategically releases the information to gain extra rewards.
Results
In this paper, we launch an EFAW attack against a single mining pool and two mining pools, respectively, and evaluate the relative extra rewards of the attacker with theoretical analysis and Monte Carlo simulation experiments. Our experimental data indicate that this attack can earn more rewards than FAW attacks.
Conclusion
The experimental results demonstrate that the lower bound of earnings in the EFAW attack is higher than in FAW attacks, and it is directly proportional to the number of miners isolated by the attacker’s eclipse attack in the victim pool. This indicates that the EFAW attack poses a greater threat compared to FAW attacks, representing one of the major conclusions drawn from the study.
Proposta de melhorias no processo de beneficiamento de polpas de açaí
Authors: Carneiro Marian , Alves Tassy Walveria , Monteiro Mariana da Silva , Ueoka Nyna Arisa , Silva Giovanna Moreira 
Published: December 2023

A comercialização do fruto açaí se intensificou bastante a partir de 1990, o que aumentou a demanda e o preço do fruto, além de ter atraído novos investimentos em indústrias de beneficiamento de polpas de açaí para a região do nordeste do estado do Pará. Dessa forma, o objetivo desse trabalho é, por meio dos princípios e métodos do Lean Seis Sigma, propor melhorias no processo de beneficiamento de polpas de açaí. Tais melhorias objetivam reduzir o tempo de paradas de máquinas, a fim de proporcionar à empresa maior rentabilidade, bem como o desenvolvimento do fluxo contínuo. Primeiro foi realizado um estudo acerca da literatura para compreender as metodologias do Lean Manufacturing, Seis Sigma e como elas se complementam, o Lean Seis Sigma. Em seguida, utilizou-se o método do Seis Sigma, o DMAIC, com as fases Definir, Medir e Analisar. Na fase, foram identificados os principais motivos e o percentual de paradas que cada um representa dentro da linha, tais como: falta de produto na área de processo −33,75%, falta de ordem de produção −23,91%, troca de laminados e bobinas − 12,7%, limpeza antes da produção −7,49% e quebra/falha mecânica − 7,35%, que juntos somam 85,2% do total de paradas da linha. Sendo assim, para cada motivo identificado foi proposto um plano de ação para reduzir ou eliminá-lo. As principais limitações da pesquisa se referem à ausência de equipe qualificada, bem como uma cultura organizacional centralizada, que permitisse análises de dados mais rápidas. Dentre as principais implicações práticas, é possível citar o uso de métodos estatísticos para a tomada de decisão na agroindústria de açaí, um setor que tem buscado a profissionalização da gestão e melhoria na oferta de seus produtos.
Palavras-chave: Indústria do açaí; Aplicação Lean Seis Sigma; Redução de Paradas; Fluxo.
Diagnosis, Treatment, and Outcomes of Crystalline Arthropathy in the Setting of Total Knee Arthroplasty
Authors: Huffman Nickelas , Pasqualini Ignacio , Surace Peter , Molloy Robert M. , Piuzzi Nicolas S. , Deren Matthew E. 
Published: December 2023

» Emerging evidence suggests the prevalence of crystalline arthropathy (CA) in the setting of total knee arthroplasty (TKA) is increasing, and diagnosis of CA is often intricate because of symptom overlap with other common postoperative complications such as periprosthetic joint infection (PJI). Consequently, an accurate and timely diagnosis becomes pivotal in guiding the choice of treatment.» CA includes gout and calcium pyrophosphate deposition (CPPD) disease, and accurate diagnosis in patients with prior TKA requires a multifaceted approach. The diagnosis algorithm plays a critical role in determining the appropriate treatment approach.» Management of CA typically involves a conservative strategy, encompassing the administration of nonsteroidal anti-inflammatory drugs, colchicine, and steroids, regardless of whether patients have undergone prior TKA.» There is conflicting evidence on the effect CA has on the surgical outcomes in postoperative TKA patients. While these patients may expect excellent functional outcomes and pain relief, they may be at a higher risk of complications such as infections, medical complications, and revision procedures.» Additional research is required to fully comprehend the impact of CA on postoperative TKA outcomes and to establish effective strategies for enhancing patient care and optimizing long-term joint function.