bluuebunny/crossref_metadata_2025_split huggingface dataset:
Source‐To‐Sink Sedimentary Budget of the African Equatorial Atlantic Rifted Margin
Authors: Rouby Delphine , Ye Jing , Chardon Dominique , Loparev Artiom , Wildman Mark , Dall'Asta Massimo 
Published: December 2023

AbstractDespite their very low relief and erosion rates, non‐orogenic (i.e., cratonic) continental domains account for over 60% of the Earth's exposed lands. Therefore, they contribute significantly to the clastic sediments and solutes exported to the ocean and should be accounted for in global studies. Nonetheless, they have been much less studied than orogenic domains. In this study, we establish the source‐to‐sink sedimentary budget of the sub‐saharan West African cratonic domain and its Equatorial Atlantic rifted margin using published low‐temperature thermochronological data to estimate onshore denudation and regional geological cross‐sections to estimate offshore accumulation. We show that during and immediately following rifting (130‐94 Ma), the build‐up and subsequent erosion of rift‐related relief resulted in a transient, 100–200 km wide strip along the margin recording high denudation rates (>50 m/Myr), while the inland domain underwent steady and very low denudation (<10 m/Myr). Afterward, the whole onshore domain underwent very low and steady denudation. Thus, the changes in post‐rift accumulation rates documented along the rifted margin were caused by changes in the climate and/or drainage network. During the Late Cretaceous, we document a regional rise in accumulation rates caused by the enlargement of drainage areas feeding the basins by a hinterlandward migration of the continental divide. During the Paleogene, we document a general drop in accumulation rates in all the basins of the African Atlantic margins caused by the global greenhouse climate, which enhanced the development of lateritic weathering mantles, storing clastic sediments on the continent and favoring solute exports to the ocean.
Seawater‐Fluid Composition Records From Molybdenum Isotopes of Sequentially Extracted Phases of Seep Carbonate Rocks
Authors: Jia Zice , Hu Yu , Bayon Germain , Peckmann Jörn , Wang Xudong , Gong Shanggui , Li Jie , Roberts Harry H. , Chen Duofu , Feng Dong 
Published: December 2023

AbstractAuthigenic molybdenum (Moauth) in marine sediments holds great potential to archive the Mo isotopic composition of seawater and biogeochemical processes. However, the factors that control authigenic Mo isotope (δ98Moauth) distribution patterns remain poorly constrained. Here, we report Mo abundances and δ98Mo compositions for bulk‐rock (bulk) and sequentially extracted fractions—including total authigenic (auth; i.e., non‐lithogenic fraction), carbonate (carb), iron and manganese oxyhydroxides, pyrite (py), and organic fractions (OM)—of authigenic carbonates recovered from various hydrocarbon seep sites in the Gulf of Mexico and the South China Sea. Extracted pyrite fractions exhibit Mo contents varying from 0.1 to 23.4 μg/g and generally dominate the Mo budget of seep carbonate rocks. Our data indicate large ranges of δ98Mobulk and δ98Moauth values relative to NIST 3134 (0.25‰), varying from 1.02 to 1.98‰ (n = 4) and from 0.15 to 3.07‰ (n = 34), respectively. The difference in δ98Mo values between carbonate and pyrite fractions of seep carbonate rocks formed under sulfidic conditions increases with higher Moauth contents, suggesting a control of dissolved hydrogen sulfide concentrations on Mo isotope fractionation during carbonate precipitation. Compared with δ98Moauth and δ98Mopy, δ98Mocarb of seep carbonate rocks formed under sulfidic conditions shows a relatively narrow range with an average of 1.98 ± 0.31‰ (1 SD; n = 10), providing constraints on the δ98Mo composition of seawater in the course of Earth history. Overall, our findings show that the δ98Mo composition of sequentially extracted phases of carbonate‐rich sedimentary rocks can provide insights into seawater‐sediment interactions and biogeochemical pathways of Mo during early diagenesis.
Modelling the capacitance of the elongated plasma in tokamak
Authors: Miao Pengcheng , Li Ge , Zhang Song , Weng Zhiyuan , Wu Yu , Duan Zemin 
Published: December 2023

AbstractThe capacitance model suitable for the non-circular cross-section plasma is studied based on the capacitance model of the circular cross-section plasma. The coaxial elliptic-torus capacitor property is further derived and used to determine the capacity of non-circular cross-section tokamak plasma, such as EAST (Experimental Advanced Superconducting Tokamak). By testing all the physical terms in this model, we find that the capacitance $$Cp$$

Cp

) is increasing exponentially with the increase of elongation ratio (k2/k1), while the minor radius ratio (a2/a1) is just reversed at the flat-top of plasma current, and the capacitance property is implicitly included in the H-mode study during the L–H transition. It is noted that Cp-H mode is the least and Cp-I mode is approximately equal to Cp-L mode under the L-mode, I-mode and H-mode regimes based on this capacitance model in EAST. Consequently, it may be integrated into an equivalent circuit of the tokamak transformer or transport computer code of the edge plasma for use in precise simulations of fusion plasma behavior in the future, such as ITER (International Tokamak Experimental Reactor) or BEST (Burning-plasma Experimental Superconducting Tokamak) in China.
Fractional Nadeem trigonometric non-Newtonian (NTNN) fluid model based on Caputo-Fabrizio fractional derivative with heated boundaries
Authors: Nadeem Sohail , Ishtiaq Bushra , Alzabut Jehad , Hassan Ahmad M. 
Published: December 2023

AbstractThe fractional operator of Caputo-Fabrizio has significant advantages in various physical flow problems due to the implementations in manufacturing and engineering fields such as viscoelastic damping in polymer, image processing, wave propagation, and dielectric polymerization. The current study has the main objective of implementation of Caputo-Fabrizio fractional derivative on the flow phenomenon and heat transfer mechanism of trigonometric non-Newtonian fluid. The time-dependent flow mechanism is assumed to be developed through a vertical infinite plate. The thermal radiation’s effects are incorporated into the analysis of heat transfer. With the help of mathematical formulations, the physical flow system is expressed. The governing equations of the flow system acquire the dimensionless form through the involvement of the dimensionless variables. The application of Caputo-Fabrizio derivative is implemented to achieve the fractional model of the dimensionless system. An exact solution of the fractional-based dimensionless system of the equations is acquired through the technique of the Laplace transform. Physical interpretation of temperature and velocity distributions relative to the pertinent parameters is visualized via graphs. The current study concludes that the velocity distributions exhibit an accelerating nature corresponding to the increasing order of the fractional operator. Moreover, the graphical results are more significant corresponding to the greater time period.
tDCS effects in basic symbolic number magnitude processing are not significantly lateralized
Authors: Bahreini Narjes , Artemenko Christina , Plewnia Christian , Nuerk Hans-Christoph 
Published: December 2023

AbstractFunctional lateralization was previously established for various cognitive domains—but not for number processing. Although numbers are considered to be bilaterally represented in the intraparietal sulcus (IPS), there are some indications of different functional roles of the left vs. right IPS in processing number pairs with small vs. large distance, respectively. This raises the question whether number size plays a distinct role in the lateralization within the IPS. In our preregistered study, we applied anodal transcranial direct current stimulation (tDCS) over the left vs. right IPS to investigate the effect of stimulation as compared to sham on small vs. large distance, in both single-digit and two-digit number comparison. We expected that anodal tDCS over the left IPS facilitates number comparison with small distance, while anodal tDCS over the right IPS facilitates number comparison with large distance. Results indicated no effect of stimulation; however, exploratory analyses revealed that tDCS over the right IPS slowed down single-digit number processing after controlling for the training effect. In conclusion, number magnitude processing might be bilaterally represented in the IPS, however, our exploratory analyses emphasise the need for further investigation on functional lateralization of number processing.
Evaluation of complexity and deliverability of IMRT treatment plans for breast cancer
Authors: Duan Longyan , Qi Weixiang , Chen Yi , Cao Lu , Chen Jiayi , Zhang Yibin , Xu Cheng 
Published: December 2023

AbstractThis study aimed to predict the outcome of patient specific quality assurance (PSQA) in IMRT for breast cancer using complexity metrics, such as MU factor, MAD, CAS, MCS. Several breast cancer plans were considered, including LBCS, RBCS, LBCM, RBCM, left breast, right breast and the whole breast for both Edge and TrueBeam LINACS. Dose verification was completed by Portal Dosimetry (PD). The receiver operating characteristic (ROC) curve was employed to determine whether the treatment plans pass or failed. The area under the curve (AUC) was used to assess the classification performance. The correlation of PSQA and complexity metrics was examined using Spearman’s rank correlation coefficient (Rs). For LINACS, the most suitable complexity metric was found to be the MU factor (Edge Rs = − 0.608, p < 0.01; TrueBeam Rs = − 0.739, p < 0.01). Regarding the specific breast cancer categories, the optimal complexity metrics were as follows: MAD (AUC = 0.917) for LBCS, MCS (AUC = 0.681) for RBCS, MU factor (AUC = 0.854) for LBCM and MAD (AUC = 0.731) for RBCM. On the Edge LINAC, the preferable method for breast cancers was MCS (left breast, AUC = 0.938; right breast, AUC = 0.813), while on the TrueBeam LINAC, it became MU factor (left breast, AUC = 0.950) and MCS (right breast, AUC = 0.806), respectively. Overall, there was no universally suitable complexity metric for all types of breast cancers. The choice of complexity metric depended on different cancer types, locations and treatment LINACs. Therefore, when utilizing complexity metrics to predict PSQA outcomes in IMRT for breast cancer, it was essential to select the appropriate metric based on the specific circumstances and characteristics of the treatment.
Fetuin-A and its genetic association with cardiometabolic disease
Authors: Al Ali Lawien , van de Vegte Yordi J. , Said M. Abdullah , Groot Hilde E. , Hendriks Tom , Yeung Ming Wai , Lipsic Erik , van der Harst Pim 
Published: December 2023

AbstractFetuin-A acts as both an inhibitor of calcification and insulin signaling. Previous studies reported conflicting results on the association between fetuin-A and cardiometabolic diseases. We aim to provide further insights into the association between genetically predicted levels of fetuin-A and cardiometabolic diseases using a Mendelian randomization strategy. Genetic variants associated with fetuin-A and their effect sizes were obtained from previous genetic studies. A series of two-sample Mendelian randomization analyses in 412,444 unrelated individuals from the UK Biobank did not show evidence for an association of genetically predicted fetuin-A with any stroke, ischemic stroke, or myocardial infarction. We do find that increased levels of genetically predicted fetuin-A are associated with increased risk of type 2 diabetes (OR = 1.21, 95%CI 1.13–1.30, P =  < 0.01). Furthermore, genetically predicted fetuin-A increases the risk of coronary artery disease in individuals with type 2 diabetes, but we did not find evidence for an association between genetically predicted fetuin-A and coronary artery disease in those without type 2 diabetes (P for interaction = 0.03). One SD increase in genetically predicted fetuin-A decreases risk of myocardial infarction in women, but we do not find evidence for an association between genetically predicted fetuin-A and myocardial infarction in men (P for interaction =  < 0.01). Genetically predicted fetuin-A is associated with type 2 diabetes. Furthermore, type 2 diabetes status modifies the association of genetically predicted fetuin-A with coronary artery disease, indicating that fetuin-A increases risk in individuals with type 2 diabetes. Finally, higher genetically predicted fetuin-A reduces the risk of myocardial infarction in women, but we do not find evidence for an association between genetically predicted fetuin-A and myocardial infarction in men.
An experimental study of the effects of bacteria on asphaltene adsorption and wettability alteration of dolomite and quartz
Authors: Soleimani Younes , Mohammadi Mohammad-Reza , Schaffie Mahin , Zabihi Reza , Ranjbar Mohammad 
Published: December 2023

AbstractThe adsorption of asphaltene on the rock surface and the changes in its wettability are very relevant issues in flow assurance and oil recovery studies, and for carbonate reservoirs, they are even more important. During microbial enhanced oil recovery (MEOR) processes, wettability alteration is considered a crucial mechanism leading to improved oil recovery. Therefore, it is essential to understand the mechanisms of surface wettability changes by bacteria and biosurfactants and find new and reliable methods to prevent asphaltene adsorption. Hence, the main aim of this research was to investigate the effect of a mixture of thiobacillus thiooxidans and thiobacillus ferooxidans microorganisms with an optimum effective temperature of around 30 °C (referred to as mesophilic bacteria), as well as a mixture of two moderate thermophiles Sulfobacillus thermosulfidooxidans for operating temperatures around 50 °C (referred to as moderately thermophilic bacteria) on the adsorption of asphaltene samples isolated from two different crude oils onto main reservoir minerals (i.e., quartz and dolomite). The results indicated that after two weeks of mineral aging in moderate thermophilic bacteria, the adsorption of asphaltene on both minerals increased between 180 and 290%. Fourier-transform infrared spectroscopy (FTIR) analysis for quartz and dolomite samples demonstrated that after aging in bacterial solution, bonds related to the adsorption of bacterial cells and biosurfactant production appear, which are the main factors of change in wettability. Alteration in wettability towards hydrophilicity expands hydrogen bonds on the surface, thus improving asphaltene adsorption due to polar interaction. Asphaltene 1 changed the contact angle of dolomite from 53.85° to 90.51° and asphaltene 2 from 53.85° to 100.41°. However, both strains of bacteria caused a strong water-wetting effect on the dolomite rock samples. The influence of moderate thermophilic bacteria on surface wettability is more significant than that of mesophilic bacteria, which may be caused by the high protein content of these bacteria, which expands hydrogen bonding with the surface. Adsorption of asphaltenes on dolomite rocks previously aged with bacteria showed that the wetted rock samples retained their water-wet state. This study highlights the dual impact of the used microorganisms. On one hand, they significantly reduce contact angles and shift wettability towards a strongly water-wet condition, a crucial positive factor for MEOR. On the other hand, these microorganisms can elevate the adsorption of asphaltenes on reservoir rock minerals, posing a potential challenge in the form of formation damage, particularly in low-permeability reservoirs.
Vesical imaging reporting and data system (VI-RADS) could predict the survival of bladder-cancer patients who received radical cystectomy
Authors: Zhuang Juntao , Cai Lingkai , Sun Huanyou , Wu Qikai , Li Kai , Yu Ruixi , Cao Qiang , Li Pengchao , Yang Xiao , Lu Qiang 
Published: December 2023

AbstractVesical Imaging Reporting and Data System (VI-RADS) shows good potential in determining muscle-invasive bladder cancer (MIBC) patients. However, whether VI-RADS could predict the prognosis of radical cystectomy (RC) patients has not been reported. Our purpose is to determine whether VI-RADS contributed to predict oncologic outcomes. In this retrospective study, we analysed the information of bladder cancer patients who admitted to our centre from June 2012 to June 2022. All patients who underwent multiparametric magnetic resonance imaging (mpMRI) and underwent RC were included. VI-RADS scoring was performed by two radiologists blinded to the clinical data. Patients’ clinical features, pathology data, and imaging information were recorded. Kaplan–Meier method was used to estimate patients' overall survival (OS) and progression-free survival (PFS). Log-rank test was used to assess statistical differences. COX regression analysis was used to estimate risk factors. Ultimately, we included 219 patients, with 188 males and 31 females. The median age was 66 (IQR = 61–74.5) years. The VI-RADS scores were as follows: VI-RADS 1, 4 (1.8%); VI-RADS 2, 68 (31.1%); VI-RADS 3, 40 (18.3%); VI-RADS 4, 69 (31.5%); and VI-RADS 5, 38 (17.4%). Patients with VI-RADS ≥ 3 had poorer OS and PFS than those with VI-RADS < 3. The AUC of VI-RADS predicting 3-year OS was 0.804, with sensitivity of 0.824 and negative predictive value of 0.942. Multivariate COX analysis showed that VI-RADS ≥ 3 was risk factors for OS (HR = 3.517, P = 0.003) and PFS (HR = 4.175, P < 0.001). In the MIBC subgroup, patients with VI-RADS ≥ 4 had poorer OS and PFS. In the non-muscle invasive bladder cancer (NMIBC) subgroup, the prognosis of patients with VI-RADS ≥ 3 remained poorer. VI-RADS scores could effectively predict the survival of patients after RC.
Mutational spectrum and phenotypic variability of Duchenne muscular dystrophy and related disorders in a Bangladeshi population
Authors: Sarker Shaoli , Eshaque Tamannyat Binte , Soorajkumar Anjana , Nassir Nasna , Zehra Binte , Kanta Shayla Imam , Rahaman Md Atikur , Islam Amirul , Akter Shimu , Ali Mohammad Kawsar , Mim Rabeya Akter , Uddin K. M. Furkan , Chowdhury Mohammod Shah Jahan , Shams Nusrat , Baqui Md. Abdul , Lim Elaine T. , Akter Hosneara , Woodbury-Smith Marc , Uddin Mohammed 
Published: December 2023

AbstractDuchenne muscular dystrophy (DMD) is a severe rare neuromuscular disorder caused by mutations in the X-linked dystrophin gene. Several mutations have been identified, yet the full mutational spectrum, and their phenotypic consequences, will require genotyping across different populations. To this end, we undertook the first detailed genotype and phenotype characterization of DMD in the Bangladeshi population. We investigated the rare mutational and phenotypic spectrum of the DMD gene in 36 DMD-suspected Bangladeshi participants using an economically affordable diagnostic strategy involving initial screening for exonic deletions in the DMD gene via multiplex PCR, followed by testing PCR-negative patients for mutations using whole exome sequencing. The deletion mapping identified two critical DMD gene hotspot regions (near proximal and distal ends, spanning exons 8–17 and exons 45–53, respectively) that comprised 95% (21/22) of the deletions for this population cohort. From our exome analysis, we detected two novel pathogenic hemizygous mutations in exons 21 and 42 of the DMD gene, and novel pathogenic recessive and loss of function variants in four additional genes: SGCD, DYSF, COL6A3, and DOK7. Our phenotypic analysis showed that DMD suspected participants presented diverse phenotypes according to the location of the mutation and which gene was impacted. Our study provides ethnicity specific new insights into both clinical and genetic aspects of DMD.
Based on metabolomics, the optimum wind speed process parameters of flue-cured tobacco in heat pump bulk curing barn were explored
Authors: Sun Cheng Lin , Zhang Hui Lin , Zhou Dong Bo , Cheng Zhi Jun , Xie You , Rang Zhong Wen , Dai Lin Jian 
Published: December 2023

AbstractTo explore the influence of wind speed on the quality of tobacco in this study, we employed a heat pump-powered intensive curing barn and a three-stage curing process. By evaluating the influence of fan parameters on the quality of tobacco leaves at different curing stages, the optimal wind speed was determined. After adopting the optimized wind speed process, the degradation of macromolecular substances was faster, the accumulation of aroma substances was delayed to 55 °C, and the accumulation was more complete. Among them, the contents of reducing sugar and total sugar in flue-cured tobacco leaves were 22.25% and 29.2%, respectively, which were lower than those in the control group. The sugar was converted into more aroma substances, and the total amount of neutral aroma substances was 48.82% higher than that of the control group. The content of related aroma substances increased significantly. The content of petroleum ether extract related to aroma substances increased by 0.93% compared with the control group. The macromolecular substances were degraded more fully than the control group, such as the starch content decreased to 1.56%. The results of metabolomics showed that the contents of aldehydes, heterocyclic compounds, alcohols, ketones and esters increased significantly in different degrees after this process. These results show that the optimization of wind speed parameters can significantly improve the baking quality of tobacco leaves. This study provides a reference for the optimization of the flue-cured tobacco baking process.
A Word-Learning Intervention Pilot Study Utilizing Principles of Retrieval- and Criterion-Based Learning for Children With Developmental Language Disorder
Authors: Gordon Katherine R. , Storkel Holly L. , Lowry Stephanie L. , Sultani Mollee J. 
Published: December 2023

Purpose:
Vocabulary knowledge at school entry provides an essential foundation for academic and literacy learning. Thus, school entry is an important timepoint to support word learning by children with developmental language disorder (DLD). Retrieval-based training strategies support both learning and retention of words for individuals with DLD in lab-based research. Additionally, lab-based research with adults with typical development demonstrates that pairing retrieval- and criterion-based training strategies supports learning efficiency. Currently, it is unclear if retrieval- and criterion-based training in word-learning interventions is feasible and effective for children with DLD.

Method:

In this pilot study, we taught preschool- and kindergarten-age children with DLD (
N
= 7) words in an intervention format. We implemented retrieval-based training in that children were asked to retrieve and produce the forms and meanings of words. We also implemented a criterion-based approach. Words were targeted until the child retrieved the form and meaning of a word at the beginning of two sessions. We assessed learning at the end of training and retention after 2- and 8-week post-training delays.

Results:
The retrieval- and criterion-based approach was effective to support word learning for six of the seven children. Children demonstrated better learning and retention of forms than meanings. Additionally, achieving criterion with a word during training was positively related to post-training retention.

Conclusions:
A retrieval- and criterion-based approach is likely to support word learning during interventions for children with DLD. We include suggestions for future research to improve the effective and efficient implementation of these approaches.