bluuebunny/crossref_metadata_2025_split huggingface dataset:
Threats, Violence, and Weapon Use Against Children in Domestic Violence Protection Orders
Authors: Ellyson Alice M. , Adhia Avanti , Mustafa Ayah , Lyons Vivian H. , Shanahan Sandra , Rowhani-Rahbar Ali 
Published: February 2024

BACKGROUND AND OBJECTIVES
Childhood exposure to domestic violence is common, but the overlap between threats and violence against children and weapon/firearm use has not been well studied. The objectives of this study were to: assess differences in respondent firearm access and the use of weapons in granted domestic violence protection orders (DVPOs) with and without minors (individuals &lt;18 years of age); and characterize the frequency and characteristics of threats and acts of violence against minors.

METHODS
We conducted a cross-sectional study of a random sample of granted DVPOs from 2014–2020 in King County, Washington. We examined the use of threats, violence, and weapons by restrained individuals (ie, respondents) by reviewing and abstracting information from DVPO case files.

RESULTS
Respondent weapon use and firearm possession were more common among DVPOs including minors than DVPOs not including minors (weapon use: 38.2% and 33.0%; firearm possession: 23.1% and 19.1%, respectively). Almost 2 in 3 DVPOs including minors (1338 of 2029) involved threats or violence directed at a minor perpetrated by the DVPO respondent. About 1 in 3 (32.5%) DVPOs documented explicit threats, and 1 in 2 (48.9%) documented violence. Over two-thirds (680 of 993, 68.5%) of acts of violence directed at minors included a weapon.

CONCLUSIONS
We found higher lethality risk (weapon use and respondent firearm access/ownership) among DVPOs including minors. Many minors experienced threats and acts of violence involving weapons and firearms by DVPO respondents. Evidence-based safety planning strategies and training of judicial officers are needed.
Child Health Needs and the Pediatric Endocrinology Workforce: 2020–2040
Authors: Aye Tandy , Boney Charlotte M. , Orr Colin J. , Leonard Mary B. , Leslie Laurel K. , Allen David B. 
Published: February 2024

The pediatric endocrinology (PE) workforce in the United States is struggling to sustain an adequate, let alone optimal, workforce capacity. This article, one of a series of articles in a supplement to Pediatrics, focuses on the pediatric subspecialty workforce and furthers previous evaluations of the US PE workforce to model the current and future clinical PE workforce and its geographic distribution. The article first discusses the children presenting to PE care teams, reviews the current state of the PE subspecialty workforce, and presents projected headcount and clinical workforce equivalents at the national, census region, and census division level on the basis of a subspecialty workforce supply model through 2040. It concludes by discussing the educational and training, clinical practice, policy, and future workforce research implications of the data presented. Data presented in this article are available from the American Board of Pediatrics, the National Resident Matching Program, and the subspecialty workforce supply model. Aging, part-time appointments, and unbalanced geographic distribution of providers diminish the PE workforce capacity. In addition, limited exposure, financial concerns, and lifestyle perceptions may impact trainees. Additional workforce challenges are the subspecialty’s increasingly complex cases and breadth of conditions treated, reliance on international medical graduates to fill fellowship slots, and high relative proportion of research careers. The recent limitations on pediatric endocrinologists providing gender-affirming care may also impact the geographic distribution of the subspecialty’s workforce. Deliberate actions need to be taken now to continue serving the needs of children.
Ligeti and Artistic Research
Authors: Marx Wolfgang 
Published: February 2024

AbstractGyörgy Ligeti was very interested in many artistic and scientific fields and drew inspiration for his compositional work from them (his engagement with mathematics – particularly fractal geometry and chaos theory – is perhaps the best known). In this chapter I compare the concept of artistic research with Ligeti's practice and oeuvre. While the notion of artistic research was only appearing in embryonic form during the latter stages of Ligeti's career, many – though not all – of his statements seem to be suitable for describing his artistic processes. The benefit of this investigation is expected to be twofold: applying the concept of artistic research to Ligeti's approaches and practices should yield new insights on the relationship between his work and his interest in other humanities and sciences. Yet this look at Ligeti may also help to refine the concept of artistic research as discussed and applied to the artistic output of today.
Sándor Weöres's Poetry as a Catalyst for György Ligeti's Early Development
Authors: Kerékfy Márton 
Published: February 2024

AbstractSándor Weöres's poetry was a life-long passion and source of inspiration for György Ligeti. This article explores the role Weöres played in Ligeti's early development as a composer by providing insight into the genesis of all of his 13 early settings of Weöres, including the unpublished choral works Hajnal [Dawn] and Tél [Winter], the incomplete song “Nagypapa leszállt a tóba” [Grandpa descended in the pond], and the unfinished oratorio “Istar pokoljárása” [Ishtar's Journey to Hell], and by making some analytical observations on them. Ligeti's early settings of Weöres were composed in three periods. The first stage in 1946–1947 was his compositional discovery of Weöres's poetry, which seems to have acted as a fuel and a challenge for him, triggering something of a musical self-liberation. His Weöres settings in 1949–1950 may be seen as a sign of solidarity with the poet effectively silenced by Communist state authorities, while in 1952–1955, Weöres texts seem to have served specifically as material for Ligeti's experimentation with static music and serialism.
El impacto de las calificadoras de deuda en el mercado laboral
Authors: Herman Eduardo Dávila Aguja  
Published: February 2024

El presente artículo es el resultado de la investigación documental acerca de la deuda publica en Colombia, teniendo en cuenta las repercusiones en las tasas de interés tasas de cambio e interés, en el contexto de la situación y realidad económica no solamente del país sino del mundo entero, la deuda pública cobra vital importancia al constituir una de las fuentes primarias de financiación de los gobiernos en América Latina con el fin de adquirir recursos con el objeto de atender todas las demandas a fin de cumplir con su cometido social tiene como fin presentar un análisis de la deuda pública en Colombia hasta la fecha del año 2023, presentado su definición, su alcance y consecuencia en generales, concluyendo que que pese a una leve disminución que se ha venido presentado en los últimos años con respecto al Producto Interno Bruto PIB, la Deuda Pública continua siendo sustancialmente alta al constituir un 22,2% del PIB
Empirical Earthquake Source Scaling Relations for Maximum Magnitudes Estimations in Central America
Authors: Arroyo-Solórzano Mario , Belén Benito María , Alvarado Guillermo E. , Climent Alvaro 
Published: February 2024

ABSTRACT
Central America is a seismically active region where six tectonic plates (North America, Caribbean, Cocos, Nazca, Panama, and South America) interact in a subduction zone with transform faults and two triple points. This complex tectonic setting makes the maximum magnitude—Mmax—estimation a challenging task, with the crustal fault earthquakes being the most damaging in the seismic history of Central America. The empirical source scaling relations (ESSR) allow the Mmax of faults to be determined from rupture parameters. In this study, we use a dataset of well-characterized earthquakes in the region, comprising 64 events from 1972 to 2021 with magnitudes between Mw 4.1 and 7.7. The dataset incorporates records of rupture parameters (length, width, area, slip, and magnitude) and information on the faults and aftershocks associated. This database is an important product in itself, and through its use we determine which global relations fit best to our data via a residual analysis. Moreover, based on the best-quality records, we develop scaling relations for Central America (CA-ESSR) for rupture length, width, and area. These new relations were tested and compared with recent earthquakes, and logic trees are proposed to combine the CA-ESSR and the best-fit global relations. Therefore, we estimate the Mmax for 30 faults using the logic tree for rupture length, considering a total rupture of the fault and multifault scenarios. Our results suggest that in Central America rupture areas larger than other regions are required to generate the same magnitudes. We associate this with the shear modulus (μ), which seems to be lower (∼30% less) than the global mean values for crustal rocks. Furthermore, considering multifault ruptures, we found several fault systems with potential Mmax≥Mw 7.0. These findings contribute to a better understanding of regional seismotectonics and to the efficient characterization of fault rupture models for seismic hazards.
Physiology and pharmacology of glucagon-like peptide-1 receptor
Authors: Kurkin D. V. , Bakulin D. A. , Morkovin E. I. , Petrov V. I. , Strygin A. V. , Koryanova K. N. , Gorbunova Yu. V. , Kolosov Yu. A. , Ivanova O. V. , Pavlova E. V. , Dzhavakhyan M. A. , Zaborovsky A. V. , Saparova V. B. , Makarenko I. E. , Drai R. I. , Chumachenko A. N. 
Published: February 2024

Modern approaches to the treatment of type 2 diabetes mellitus (T2DM) are aimed not only at glycemic control, but also at reducing cardiovascular risks. The increasing prevalence of the disease and the need for effective treatment options highlight the importance of glucagon-like peptide-1 (GLP-1) receptor agonists in the pharmacotherapy structure.The aim of the work was to review the literature regarding the physiology of GLP-1 and the therapeutic potential and development trends of its agonists.Materials and methods. The search for the review materials was carried out using the abstract databases of PubMed, Google Scholar and e-Library. The search was carried out for publications from 2000 to 2023, using the following keywords: “GLP-1”; “GLP-1R agonists”; “GIP”; “exenatide”; “liraglutide”; “dulaglutide”; “semaglutide”; “lixisenatide”; “albiglutide”; “taspoglutide” taking into account various spellings.Results. The interaction of almost all food components with enteroendocrine cells of the intestine leads to the secretion of incretins (primarily GLP-1) into the blood, triggering a complex of physiological reactions aimed primarily at the rapid utilization of incoming glucose (regulation of insulin and glucagon secretion), as well as the central regulation of dietary behavior (slowing gastric emptying and the formation of a feeling of satiety). A wide distribution of the GLP-1 receptor in various tissues and organs, its connection with intracellular signaling cascades aimed at launching energy-consuming remodeling (recovery) processes in endothelial cells, heart, neurons, beta cells, etc., is the basis for a wide range of pleiotropic effects of GLP-1 unrelated to its hypoglycemic effect. The discovery of synthetic GLP-1 receptor agonists with a long period of action has made it possible not only to therapeutically influence various parts of carbohydrate metabolism disorders, but also to increase the functional reserves of the target diabetes organs, reducing the risk of developing complications of the disease. Incretin-like drugs are well tolerated, with nausea being the most common side effect. The factors limiting a wider use of the drugs include their high cost and the preferred form of a subcutaneous solution. The current research is focused on the development of long-acting, oral, dual and triple agonists, fixed-dose combinations, and small molecule drugs.Conclusion. GLP-1 receptor agonists are a class of effective and safe drugs for the treatment of diabetes and obesity, which is rapidly developing in the most advanced areas of pharmacy. A further development of this group and the solution of the identified problems will open up new opportunities for the treatment of diabetes and its complications.
Electrophysiological effects of kappa-opioid analgesic, RU-1205, using machine learning methods
Authors: Kalitin K. Yu. , Mukha O. Yu. , Spasov A. A. 
Published: February 2024

The study is focused to the investigation of a new kappa-opioid agonist RU-1205, which exhibits an analgesic effect without causing dysphoric or aversive actions. It is assumed that this effects may be due to its functional selectivity, or the presence of an additional mechanism of action that involves blocking p38 mitogen-activated protein kinase (MAPK).The aimof the study was an experimental identification of RU-1205 mechanisms of action associated with the inhibition of MAPK p38 and functional selectivity for kappa opioid receptors.Materials and methods.The LFP activity was recorded in the male rats weighing 260–280 g (n=62) and implanted with chronic cortical and deep electrodes, after the intracerebroventricular administration of the well-studied reference substances: the selective kappa-opioid agonist U-50488 100 μg; the MAPK p38 blocker SB203580 1 μg; and the investigational compound RU-1205 at 350 μg. The weighted phase lag index (WPLI) was calculated. Subsequently, machine learning methods were employed to reduce the dimensionality and extract connectivity features using the principal component analysis method, then a signal classification was performed (models based on Gaussian processes). Using the local patch-clamp technique in the “whole-cell” configuration, the spike activity of pyramidal neurons in the basolateral amygdala was studied. Neurons were identified by their accommodation properties. After local perfusion of the test compounds, 3 dose-response curves were obtained for: (1) U-50488 at concentrations ranging from 0.001 to 10 μM; (2) combinations of U-50488 (0.001–10 μM) and RU-1205 (10 μM); and (3) the combinations of U-50488 (0.01–10 μM) and RU-1205 (100 μM).Results.The developed models made it possible to classify the compound RU-1205 as a “non-inhibitor” of MAPK p38 with a high probability. The results obtained were confirmed in patch-clamp experiments on acute brain slices where it was demonstrated that U-50488 statistically significantly increases the spike activity of pyramidal neurons of the basolateral amygdala (p <0.05), and RU-1205 interacts with U-50488, competitively suppressing its effect on the spike activity of neurons.Conclusion.The findings suggest that compound RU-1205 displays properties consistent with a functional kappa agonist activity and does not have a significant effect on MAPK p38. The study demonstrates the possibility of integrating electrophysiological measurements and advanced data analysis methods for a deep understanding of drug action and underscores the potential for further research in this area.
Composition and technology development of ear drops with cerumenolytic action (based on thick Viscum album L. leaves extract)
Authors: Pozdnyakova A. E. , Adzhiakhmetova S. L. , Sergeeva E. O. , Pozdnyakov D. I. , Yurtaeva E. A. , Borodina I. O. , Kompantsev D. V. 
Published: February 2024

Earwaxes lead to a decrease in the quality of life. A rational and effective way to eliminate earwaxes without a participation of medical personnel is to use ear drops and solutions to dissolve sulfur masses. In this regard, therapeutic and hygienic drops of а cerumenolytic action are of a particular relevance in the pharmaceutical market.The aim of the work was to develop a composition and technology of ear drops of a cerumenolytic action based on thick Viscum Album L. leaves extract.Materials and methods. The objects of the study were thick Viscum Album L. leaf extract, chitosan, sodium alginate, polyethylene oxide of various degrees of polymerization, propylene glycol, sodium hyaluronate, preservatives (benzalkonium chloride, nipagine and nipazole). At the screening stage, 9 experimental formulations were proposed. The cerumenolytic activity of the developed formulations was evaluated in a dissolution test of reproduced artificial earwax in comparison with a 3% hydrogen peroxide solution, TEA-cocoyl hydrolyzed collagen (A-Cerumen Plus, Gilbert Laboratories, France) and a 0.9% sodium chloride solution. Physical and chemical parameters (a degree of liquid coloring, turbidity and transparency, pH, density and viscosity) were determined according to of the State Pharmacopoeia of the Russian Federation (XV ed.). The microbiological study was performed using the agar diffusion method.Results. In the course of the study, it was shown that the composition of ear drops of a cerumenolytic action based on thick Viscum Album L. leaves extract, exceeds the level of a lipolytic, proteolytic and general cerumenolytic kinds of activity of the compositions containing surfactants; in its effectiveness, it was comparable with the comparison drug – A-Cerumen drops. To obtain the optimal rate of the onset effect and its duration, it is advisable to use sodium hyaluronate in the amount of 0.2 g per 25 ml of drops as an adjuvant. The most preferred preservative was benzalkonium chloride. The developed ear drops met the requirements of the State Pharmacopoeia of the Russian Federation (XV ed.) for this dosage form, while the pH was 5.86± 0.1, and the viscosity was 4.2676±0.2 MPa×s.Conclusion. The conducted research has shown the prospects for further work on the development and implementation of ear drops of a cerumenolytic action in practice. The recommended composition is the following: thick Viscum Album L. leaf extract, sodium hyaluronate, benzalkonium chloride, purified water.
Effect of insertion/deletion polymorphism of angiotensin-converting enzyme gene on efficacy of antihypertensive therapy with angiotensin II receptor blockers
Authors: Rebrova E. V. , Shikh E. V. 
Published: February 2024

The efficacy of the antihypertensive therapy may be related to genetic factors that can influence not only the degree of the blood pressure (BP) elevation but also contribute to the interindividual variability of response to the antihypertensive treatment.The aim of the work was to study pharmacodynamic parameters of the therapy efficacy with angiotensin II receptor blockers in the form of monotherapy and as part of combined drugs in patients with the arterial hypertension depending on the genetic features of patients – polymorphism of the gene encoding angiotensin-converting enzyme, or I/D-polymorphism.Materials and methods. The study included 179 patients of the Moscow region with a first-diagnosed arterial hypertension (AH) of 1–2 degree, including 141 (78.8%) women and 38 (21.2%) men aged from 32 to 69 years. By a simple randomization method, the patients were randomly allocated into groups receiving irbesartan and valsartan as mono- or combination therapy with hydrochlorthiazide. After 3 weeks of this pharmacotherapy, the presence of rs4646994 Alu Ins / Del genetic polymorphism of the angiotensin-converting enzyme (ACE) gene and the minimum equilibrium concentration of angiotensin II receptor blockers (ARBs) were determined.Results. The patients treated with irbesartan, the D/D genotype carriers, were significantly less likely to reach the target BP and more likely to require a pharmacotherapy intensification compared to I/D heterozygotes (p=0.042 and p=0.058, respectively) and I/I homozygotes (p=0.011 and p=0.011, respectively). The patients treated with valsartan, the D/D genotype carriers, significantly more often reached the target BP and significantly less often required a pharmacotherapy intensification than the I/D genotype carriers (p=0.05 and p=0.05, respectively). Herewith, at the end of the study, according to the results of the office BP measurements and daily BP monitoring, the target BP achievement was not significantly correlated with the I/D polymorphism of the ACE gene.Conclusion. When personalizing the AH therapy in patients of the Moscow region, the genotype I/I carriers by I/D polymorphism of the ACE gene, can be recommended irbesartan in the form of mono- or bicomponent therapy as a starting therapy of ARBs; the D/D genotype carriers can be recommended valsartan. A more pronounced decrease in the daytime systolic BP (SBP), the daytime diastolic BP (DBP) and the nighttime SBP variabilities in the valsartan group of patients, the D allele carriers may indicate a more persistent effect of the antihypertensive therapy.
How Contingency Adjusts CSR in Tourism Industry: A Quasi Experiment in China
Authors: Wang Hao , Zhang Tao , Wang Xi , Zheng Jiansong , Zhao You , Cai Rongjiang , Liu Xia , Jia Qiaoran , Zhu Zehua , Jiang Xiaolong 
Published: February 2024

Although numerous organizational researchers have acknowledged that COVID-19 shocks reduced the tourism industry’s financial performance, relevant literature remains scarce. Do tourism firms reduce corporate social responsibility (CSR) investments to decrease costs? The answer is unclear. This study fills the gap between stakeholder and cost stickiness theories. Based on a quasi-natural experiment of listed Chinese tourism companies from 2017 to 2021, the study finds that the COVID-19 shock caused tourism firms to increase strategic and decrease responsive CSR. In addition, tourism firms that adopted cost leadership strategies trimmed responsive CSR more than strategic CSR. Tourism firms with differentiated leadership strategies increased strategic and decreased responsive CSR. Tourism firms with higher levels of political connections increased responsive CSR, while tourism firms with higher organizational resilience increased strategic CSR. At the theoretical level, this study reveals the theoretical mechanism of the COVID-19 epidemic’s shock on tourism firms&#039; adjustment of CSR from the perspective of cost stickiness. On a practical level, it helps inform tourism firms’ decision-making regarding CSR adjustments for sustainable development when they face widespread crisis scenarios.
1965 US Voting Rights Act Impact on Black and Black Versus White Infant Death Rates in Jim Crow States, 1959–1980 and 2017–2021
Authors: Rushovich Tamara , Nethery Rachel C. , White Ariel , Krieger Nancy 
Published: February 2024

Objectives. To investigate the impact of the US Voting Rights Act (VRA) of 1965 on Black and Black versus White infant deaths in Jim Crow states. Methods. Using data from 1959 to 1980 and 2017 to 2021, we applied difference-in-differences methods to quantify differential pre–post VRA changes in infant deaths in VRA-exposed versus unexposed counties, controlling for population size and social, economic, and health system characteristics. VRA-exposed counties, identified by Section 4, were subject to government interventions to remove existing racist voter suppression policies. Results. Black infant deaths in VRA-exposed counties decreased by an average of 11.4 (95% confidence interval [CI] = 1.7, 21.0) additional deaths beyond the decrease experienced by unexposed counties between the pre-VRA period (1959–1965) and the post-VRA period (1966–1970). This translates to 6703 (95% CI = 999.6, 12 348) or 17.5% (95% CI = 3.1%, 28.1%) fewer deaths than would have been experienced in the absence of the VRA. The equivalent differential changes were not significant among the White or total population. Conclusions. Passage of the VRA led to pronounced reductions in Black infant deaths in Southern counties subject to government intervention because these counties had particularly egregious voter suppression practices. ( Am J Public Health. 2024;114(3):300–308. https://doi.org/10.2105/AJPH.2023.307518 )