bluuebunny/crossref_metadata_2025_split huggingface dataset:
SUMOylation of TEAD1 Modulates the Mechanism of Pathological Cardiac Hypertrophy
Authors: Shi Xin , Dang Xuening , Huang Zhenyu , Lu Yanqiao , Tong Huan , Liang Feng , Zhuang Fei , Li Yi , Cai Zhaohua , Huo Huanhuan , Jiang Zhaolei , Pan Changqing , Wang Xia , Gu Chang , He Ben 
Published: January 2024

AbstractPathological cardiac hypertrophy is the leading cause of heart failure and has an extremely complicated pathogenesis. TEA domain transcription factor 1 (TEAD1) is recognized as an important transcription factor that plays a key regulatory role in cardiovascular disease. This study aimed to explore the role of TEAD1 in cardiac hypertrophy and to clarify the regulatory role of small ubiquitin‐like modifier (SUMO)‐mediated modifications. First, the expression level of TEAD1 in patients with heart failure, mice, and cardiomyocytes is investigated. It is discovered that TEAD1 is modified by SUMO1 during cardiac hypertrophy and that the process of deSUMOylation is regulated by SUMO‐specific protease 1 (SENP1). Lysine 173 is an essential site for TEAD1 SUMOylation, which affects the protein stability, nuclear localization, and DNA‐binding ability of TEAD1 and enhances the interaction between TEAD1 and its transcriptional co‐activator yes‐associated protein 1 in the Hippo pathway. Finally, adeno‐associated virus serotype 9 is used to construct TEAD1 wild‐type and KR mutant mice and demonstrated that the deSUMOylation of TEAD1 markedly exacerbated cardiomyocyte enlargement in vitro and in a mouse model of cardiac hypertrophy. The results provide novel evidence that the SUMOylation of TEAD1 is a promising therapeutic strategy for hypertrophy‐related heart failure.
A Robust Biomimetic Superhydrophobic Coating with Superior Mechanical Durability and Chemical Stability for Inner Pipeline Protection
Authors: Zang Xuerui , Bian Jiang , Ni Yimeng , Zheng Weiwei , Zhu Tianxue , Chen Zhong , Cao Xuewen , Huang Jianying , Lai Yuekun , Lin Zhiqun 
Published: January 2024

AbstractDurable superhydrophobic anti‐erosion/anticorrosion coatings are highly demanded across various applications. However, achieving coatings with exceptional superhydrophobicity, mechanical strength, and corrosion resistance remains a grand challenge. Herein, a robust microstructure coating, inspired by the cylindrical structures situated on the surface of conch shell, for mitigating erosion and corrosion damages in gas transportation pipelines is reported. Specifically, citric acid monohydrate as a pore‐forming agent is leveraged to create a porous structure between layers, effectively buffering the impact on the surface. As a result, the coating demonstrates remarkable wear resistance and water repellency. Importantly, even after abrasion by sandpaper and an erosion loop test, the resulting superhydrophobic surfaces retain the water repellency. The design strategy offers a promising route to manufacturing multifunctional materials with desired features and structural complexities, thereby enabling effective self‐cleaning and antifouling abilities in harsh operating environments for an array of applications, including self‐cleaning windows, antifouling coatings for medical devices, and anti‐erosion/anticorrosion protection, among other areas.
Advanced Tuneable Micronanoplatforms for Sensitive and Selective Multiplexed Spectroscopic Sensing via Electro‐Hydrodynamic Surface Molecular Lithography
Authors: Gomes Paulo De Carvalho , Hin‐Chu Martin , Rickard Jonathan James Stanley , Goldberg Oppenheimer Pola 
Published: January 2024

AbstractMicro‐ and nanopatterning of materials, one of the cornerstones of emerging technologies, has transformed research capabilities in lab‐on‐a‐chip diagnostics. Herein, a micro‐ and nanolithographic method is developed, enabling structuring materials at the submicron scale, which can, in turn, accelerate the development of miniaturized platform technologies and biomedical sensors. Underpinning it is the advanced electro‐hydrodynamic surface molecular lithography, via inducing interfacial instabilities produces micro‐ and nanostructured substrates, uniquely integrated with synthetic surface recognition. This approach enables the manufacture of design patterns with tuneable feature sizes, which are functionalized via synthetic nanochemistry for highly sensitive, selective, rapid molecular sensing. The development of a high‐precision piezoelectric lithographic rig enables reproducible substrate fabrication with optimum signal enhancement optimized for functionalization with capture molecules on each micro‐ and nanostructured array. This facilitates spatial separation, which during the spectroscopic sensing, enables multiplexed measurement of target molecules, establishing the detection at minute concentrations. Subsequently, this nano‐plasmonic lab‐on‐a‐chip combined with the unconventional computational classification algorithm and surface enhanced Raman spectroscopy, aimed to address the challenges associated with timely point‐of‐care detection of disease‐indicative biomarkers, is utilized in validation assay for multiplex detection of traumatic brain injury indicative glycan biomarkers, demonstrating straightforward and cost‐effective micro‐ and nanoplatforms for accurate detection.
Dry Laser‐Induced Graphene Fractal‐like ECG Electrodes
Authors: Houeix Yann , Gerardo Denice , Romero Francisco J. , Toral Víctor , Hernandez Lidia , Rivadeneyra Almudena , Castillo Encarnación , Morales Diego P. , Rodriguez Noel 
Published: January 2024

AbstractFractal‐like geometries applied to biosignal‐electrodes design show great potential for enhancing the signal acquisition of sensing systems. This study reports a novel approach for flexible, silver‐free, and dry fractal‐like electrodes based on Laser‐Induced Graphene (LIG) obtained through laser photothermal processing of a commercial polyimide film. This one‐step mask‐less manufacturing process enables the simple fabrication of natural and optimized fractal‐like shapes inspired by actual snowflake patterns. To ensure a reliable and standardized connection to the measurement unit, the electrodes are equipped with a snap terminal. The electrodes are structurally characterized using various techniques including Scanning Electron Microscopy (SEM), Raman spectroscopy, and X‐ray Photoelectron Spectroscopy (XPS). By benchmarking the performance of these electrodes against Ag/AgCl wet commercial electrodes and LIG electrodes shaped as commercial ones, a heart rate‐monitoring accuracy of over 96.8% is achieved, with high specificity, positive prediction, and sensitivity, surpassing the 95.8% achieved by conventional commercial electrodes. These results demonstrate the efficacy of fractal‐based designs in combination with LIG‐based transduction, offering flexible and cost‐effective electrocardiogram (ECG) electrodes with improved performance compared to traditional wet electrodes.
Self‐Regulating Interfacial Space Charge through Polyanion Repulsion Effect towards Dendrite‐Free Polymer Lithium‐Metal Batteries
Authors: Cui Manying , Gao Na , Zhao Wenshan , Zhao Hongyang , Cao Zhenjiang , Qin Yanyang , Gao Guoxin , Xi Kai , Su Yaqiong , Ding Shujiang 
Published: January 2024

AbstractUncontrolled transport of anions leads to many issues, including concentration polarization, excessive interface side reactions, and space charge‐induced lithium dendrites at the anode/electrolyte interface, which severely deteriorates the cycling stability of lithium metal batteries. Herein, an asymmetrical polymer electrolyte modified by a boron‐containing single‐ion conductor (LiPVAOB), is designed to inhibit the nonuniform aggregation of free anions in the vicinity of the lithium anode through the repulsion effect improving the lithium‐ion transference number to 0.63. This LiPVAOB exerts a repulsion interaction with free anions even at a long distance and a selective effect for free anions transport, which diminishes uneven aggregation of free anions at the interface and suppresses space charges‐induced lithium dendrites growth. Consequently, the assembled Li||Li cell delivers an ultra‐long cycle for over 5400 h. The Li||LiFePO4 cell exhibits outstanding cycle performance with a capacity retention of 93% over 4500 cycles. In particular, the assembled high‐voltage Li||Li1.2Ni0.2Mn0.6O2 cell (charged to 4.8 V) exhibits good cycle stability with a high specific capacity of 245 mAh g−1. This designed polymer electrolyte provides a promising strategy for regulating ion transport to inhibit space charge‐induced lithium dendrite growth for high‐performance lithium metal batteries.
Dithiophosphoric Acids for Polymer Functionalization
Authors: Bao Jianhua , Kang Kyung‐Seok , Molineux Jake , Bischoff Derek J. , Mackay Michael E. , Pyun Jeffrey , Njardarson Jon T. 
Published: January 2024

AbstractDithiophosphoric acids (DTPAs) are an intriguing class of compounds that are sourced from elemental sulfur and white phosphorus and are prepared from the reaction of phosphorus pentasulfide with alcohols. The electrophilic addition of DTPAs to alkenes and unsaturated olefinic substrates is a known reaction, but has not been applied to polymer synthesis and polymer functionalization. We report on the synthesis and application of DTPAs for the functionalization of challenging poly‐enes, namely polyisoprene (PI) and polynorbornene (pNB) prepared by ring‐opening metathesis polymerization (ROMP). The high heteroatom content within DTPA moieties impart intriguing bulk properties to poly‐ene materials after direct electrophilic addition reactions to the polymer backbone introducing DTPAs as side chain groups. The resulting materials possess both enhanced optical and flame retardant properties vs the poly‐ene starting materials. Finally, we demonstrate the ability to prepare crosslinked polydiene films with di‐functional DTPAs, where the crosslinking density and thermomechanical properties can be directly tuned by DTPA feed ratios.
Stabilizing Ni‐rich Single‐crystalline LiNi0.83Co0.07Mn0.10O2 Cathodes using Ce/Gd Co‐doped High‐entropy Composite Surfaces
Authors: Li Jing , Yang Hui , Deng Qiang , Li Wanming , Zhang Qimeng , Zhang Zihan , Chu Youqi , Yang Chenghao 
Published: January 2024

AbstractNi‐rich layered oxides are promising lithium‐ion batteries (LIBs) cathode materials for their high reversible capacity, but they suffer from fast structural degradation during cycling. Here, we report the Ce/Gd incorporated single‐crystalline LiNi0.83Co0.07Mn0.10O2 (SC‐NCM) cathode materials with significantly enhanced cycling stability. The Gd ions are adequately incorporated in SC‐NCM while Ce ions are prone to aggregate in the outer surface, resulting in the formation of a high‐entropy zone in the near‐surface of SC‐NCM, including a Gd doped LiCeO2 (LCGO) shell and Ce/Gd dopant‐concentrated layer. The high‐entropy zone can effectively inhibit the oxygen evolution and prevent the formation of oxygen vacancies. Meanwhile, it leads to a greatly improved H2‐H3 phase transformation reversibility and mitigated stress/strain caused by Li‐ion extraction/insertion during (de)lithiation process. The synergetic effects of reduced oxygen vacancies concentration and mitigated stress/strain can effectively prevent the in‐plane migration of TM ions, lattice planar gliding as well as the formation of intragranular nanocracks. Consequently, Ce/Gd incorporated SC‐NCM (SC‐NCM@CG2) delivers a high initial discharge specific capacity of 219.7 mAh g−1 at 0.1 C and an excellent cycling stability with a capacity retention of 90.2 % after 100 cycles at 1.0 C.
Lithiophilic Covalent Organic Framework as Anode Coating for High‐Performance Lithium Metal Batteries
Authors: Wu Xinyu , Zhang Shuoqing , Xu Xiaoyi , Wen Fuxiang , Wang Hanwen , Chen Hongzheng , Fan Xiulin , Huang Ning 
Published: January 2024

AbstractThe growth of disorganized lithium dendrites and weak solid electrolyte interphase greatly impede the practical application of lithium metal batteries. Herein, we designed and synthesized a new kind of stable polyimide covalent organic frameworks (COFs), which have a high density of well‐aligned lithiophilic quinoxaline and phthalimide units anchored within the uniform one‐dimensional channels. The COFs can serve as an artificial solid electrolyte interphase on lithium metal anode, effectively guiding the uniform deposition of lithium ions and inhibiting the growth of lithium dendrites. The unsymmetrical Li||COF−Cu battery exhibits a Coulombic efficiency of 99 % at a current density of 0.5 mA cm−2, which can be well retained up to 400 cycles. Meanwhile, the Li‐COF||LFP full cell shows a Coulombic efficiency over 99 % at a charge of 0.3 C. And its capacity can be well maintained up to 91 % even after 150 cycles. Therefore, the significant electrochemical cycling stability illustrates the feasibility of employing COFs in solving the disordered deposition of lithium ions in lithium metal batteries.
Ambient Catalytic Spinning of Polyethylene Nanofibers
Authors: Wu Ruikai , Lenz Tim M. , Alfayez Fayez Abdullah S , Zhao Ruohan , Rupper Patrick , Perret Edith , Lehner Sandro , Jovic Milijana , Gaan Sabyasachi , Rieger Bernhard , Heuberger Manfred 
Published: January 2024

AbstractA novel single‐atom Ni(II) catalyst (Ni‐OH) is covalently immobilized onto the nano‐channels of mesoporous Santa Barbara Amorphous (SBA)‐15 particles and isotropic Anodized Aluminum Oxide (AAO) membrane for confined‐space ethylene extrusion polymerization. The presence of surface‐tethered Ni complexes (Ni@SBA‐15 and Ni@AAO) is confirmed by the inductively coupled plasma‐optical emission spectrometry (ICP‐OES) and X‐ray photoelectron spectroscopy (XPS). In the catalytic spinning process, the produced PE materials exhibit very homogeneous fibrous morphology at nanoscale (diameter: ~50 nm). The synthesized PE nanofibers extrude in a highly oriented manner from the nano‐reactors at ambient temperature. Remarkably high Mw (1.62×106 g mol−1), melting point (124 °C), and crystallinity (41.8 %) are observed among PE samples thanks to the confined‐space polymerization. The chain‐walking behavior of surface tethered Ni catalysts is greatly limited by the confinement inside the nano‐channels, leading to the formation of very low‐branched PE materials (13.6/1000 C). Due to fixed supported catalytic topology and room temperature, the filaments are expected to be free of entanglement. This work signifies an important step towards the realization of a continuous mild catalytic‐spinning (CATSPIN) process, where the polymer is directly synthesized into fiber shape at negligible chain branching and elegantly avoiding common limitations like thermal degradation or molecular entanglement.
Invertebrate diversity associated with a shallow rhodolith bed in the Mediterranean Sea (Mar Piccolo of Taranto, south‐east Italy)
Authors: Pierri Cataldo , Longo Caterina , Falace Annalisa , Gravina Maria F. , Gristina Michele , Kaleb Sara , Lazic Tamara , Lisco Stefania , Moretti Massimo , Putignano Matteo , Ravisato Miriam , Trani Roberta , Dadamo Marco , Albano Paolo G. 
Published: January 2024

Abstract

Rhodoliths, formed by free‐living coralline algae, are distributed worldwide, and the rhodolith beds (RBs) that they form are recognized as structurally complex habitats. In the Mediterranean, they are generally distributed in the mesophotic zone, at depths of 30–100 m; so far, only a few shallow RBs (<2 m) have been reported (e.g. Îles Kuriat, Tunisia, and Stagnone Marsala, Italy).
Here a shallow‐water RB located in the Mar Piccolo of Taranto (south‐eastern Italy, Mediterranean Sea) is described. The diversity of associated invertebrates, the rhodolith‐forming algal species, the type of sediments, and the bed extent are characterized.
The RB investigated extends over 5 ha at depths of 0.5–1.5 m. The rhodoliths vary in shape and size, from pralines to large spherical structures, and are formed by a single species, Neogoniolithon brassica‐florida, growing around nuclei of both natural and anthropogenic origin. The associated fauna consisted of 158 taxa, 79 (50%) of which were new basin records. The associated diversity was approximately twice that of the underlying and nearby sediments.
The structural complexity of the RBs promotes biodiversity and provides shelter, food, and a breeding ground for numerous species, including seahorses, which are a conservation priority in this basin.
Calprotectin Impairs Platelet Survival in Patients With Primary Antiphospholipid Syndrome
Authors: Hoy Claire K. , NaveenKumar Somanathapura K. , Navaz Sherwin A. , Sugur Kavya , Yalavarthi Srilakshmi , Sarosh Cyrus , Smith Tristin , Kmetova Katarina , Chong Emily , Peters Noah F. , Rysenga Christine E. , Norman Gary L. , Figueroa‐Parra Gabriel , Nelson Dava , Girard Jennifer , Ahmed Asra Z. , Schaefer Jordan K. , Gudjonsson Johann E. , Kahlenberg J. Michelle , Madison Jacqueline A. , Knight Jason S. , Crowson Cynthia S. , Duarte‐García Alí , Zuo Yu 
Published: January 2024

ObjectiveWhile thrombosis and pregnancy loss are the best‐known clinical features of antiphospholipid syndrome (APS), many patients also exhibit “extra‐criteria” manifestations, such as thrombocytopenia. The mechanisms that drive APS thrombocytopenia are not completely understood, and no clinical biomarkers are available for predicting antiphospholipid antibody (aPL)–mediated thrombocytopenia. Calprotectin is a heterodimer of S100A8 and S100A9 that is abundant in the neutrophil cytoplasm and released upon proinflammatory neutrophil activation. Here, we sought to evaluate the presence, clinical associations, and potential mechanistic roles of circulating calprotectin in a cohort of primary APS and aPL‐positive patients.MethodsLevels of circulating calprotectin were determined in plasma by the QUANTA Flash chemiluminescent assay. A viability dye‐based platelet assay was used to assess the potential impact of calprotectin on aPL‐mediated thrombocytopenia.ResultsCirculating calprotectin was measured in 112 patients with primary APS and 30 aPL‐positive (without APS criteria manifestations or lupus) patients as compared to patients with lupus (without APS), patients with unprovoked venous thrombosis (without aPL), and healthy controls. Levels of calprotectin were higher in patients with primary APS and aPL‐positive patients compared to healthy controls. After adjustment for age and sex, calprotectin level correlated positively with absolute neutrophil count (r = 0.41, P < 0.001), positively with C‐reactive protein level (r = 0.34, P = 0.002), and negatively with platelet count (r = −0.24, P = 0.004). Mechanistically, we found that calprotectin provoked aPL‐mediated thrombocytopenia by engaging platelet surface toll‐like receptor 4 and activating the NLRP3‐inflammasome, thereby reducing platelet viability in a caspase‐1‐dependent manner.ConclusionThese data suggest that calprotectin has the potential to be a functional biomarker and a new therapeutic target for APS thrombocytopenia.image
Quantitative assessment of the potential of optimal estimation for aerosol retrieval from geostationary weather satellites in the frame of the iAERUS‐GEO algorithm
Authors: Georgeot Adèle , Ceamanos Xavier , Attié Jean‐Luc 
Published: January 2024

AbstractSatellite remote sensing enables the study of atmospheric aerosols at large spatial scales, with geostationary platforms making this possible at sub‐daily frequencies. High‐temporal‐resolution aerosol observations can be made from geostationary data by using robust numerical inversion methods such as the widely‐used optimal estimation (OE) theory. This is the case of the instantaneous Aerosol and surfacE Retrieval Using Satellites in GEOstationary orbit (iAERUS‐GEO) algorithm, which successfully retrieves aerosol optical depth (AOD) maps from the Meteosat Second Generation weather satellite based on a simple implementation of the OE approach combined with the Levenberg–Marquardt method. However, the exact gain in inversion performances that can be obtained from the multiple and more advanced possibilities offered by OE is not well documented in the current literature. Against this background, this article presents the quantitative assessment of OE for the future improvement of the iAERUS‐GEO algorithm. To this end, we use a series of comprehensive experiments based on AOD maps retrieved by iAERUS‐GEO using different OE implementations, and ground‐based observations used as reference data. First, we assess the varying importance in the inversion process of satellite observations and a priori information according to the content of satellite aerosol information. Second, we quantify the gain of AOD estimation in log space versus linear space in terms of accuracy, AOD distribution and number of successful retrievals. Finally, we evaluate the accuracy improvement of simultaneous AOD and surface reflectance retrieval as a function of the regions covered by the Meteosat Earth's disk.
Enzymatic properties of ornithine decarboxylase from Clostridium aceticum DSM1496
Authors: Tan Qian , Gou Linbo , Fan Tai‐Ping , Cai Yujie 
Published: January 2024

AbstractClostridium aceticum DSM1496 is an acid‐resistant strain in which ornithine decarboxylase (ODC) plays a crucial role in acid resistance. In this study, we expressed ODC derived from C. aceticum DSM1496 in Escherichia coli BL21 (DE3) and thoroughly examined its enzymatic properties. The enzyme has a molecular weight of 55.27 kDa and uses pyridoxal‐5′‐phosphate (PLP) as a coenzyme with a Km = 0.31 mM. ODC exhibits optimal activity at pH 7.5, and it maintains high stability even at pH 4.5. The peak reaction temperature for ODC is 30°C. Besides, it can be influenced by certain metal ions such as Mn2+. Although l‐ornithine serves as the preferred substrate for ODC, the enzyme also decarboxylates l‐arginine and l‐lysine simultaneously. The results indicate that ODC derived from C. aceticum DSM1496 exhibits the ability to produce putrescine, cadaverine, and agmatine through decarboxylation. These polyamines have the potential to neutralize acid in an acidic environment, facilitating the growth of microorganisms. These significant findings provide a strong basis for further investigation into the acid‐resistant mechanisms contributed by ODC.
Preclinical Evaluation of Azabenzimidazole‐Based PET Radioligands for γ‐8 Dependent Transmembrane AMPA Receptor Regulatory Protein Imaging
Authors: Chen Jiahui , Li Yinlong , Yu Qingzhen , Patel Jimmy S. , Zhou Xin , Zhang Kuo , Rong Jian , Zhao Chunyu , Chaudhary Ahmad F. , Zhang Wei , Bi Chunyang , Song Zhendong , Davenport April T. , Daunais James B. , Haider Achi , Collier Lee , Yuan Hongjie , Liang Steven 
Published: January 2024

AbstractAMPA glutamate receptors (AMPARs) play a pivotal role in excitatory neurotransmission, particularly in the hippocampus where the TARP γ‐8 subunit is enriched and serves as a target for emerging anti‐epileptic drugs. To enable in vivo visualization of TARP γ‐8 distribution and expression by positron emission tomography (PET), this study focuses on the development of novel 18F‐labeled TARP γ‐8 inhibitors and their corresponding precursors, stemming from the azabenzimidazole scaffold. The resulting radioligands [18F]TARP‐2204 and [18F]TARP‐2205 were successfully synthesized with acceptable radiochemical yield, high molar activity, and excellent radiochemical purity. In vitro autoradiography demonstrates high level of specific binding of [18F]TARP‐2205 to TARP γ‐8 in both rat and nonhuman primate brain tissues. However, unexpected radiodefluorination in PET imaging studies of rodents emphasizes the need for further structural refinement. This work serves as an excellent starting point for the development of future 18F‐labeled TARP γ‐8 PET tracers, offering valuable insights into medicinal chemistry design, radiosynthesis and subsequent PET evaluation.