bluuebunny/crossref_metadata_2025_split huggingface dataset:
MYSM1 acts as a novel co-activator of ERα to confer antiestrogen resistance in breast cancer
Authors: Luan Ruina , He Mingcong , Li Hao , Bai Yu , Wang Anqi , Sun Ge , Zhou Baosheng , Wang Manlin , Wang Chunyu , Wang Shengli , Zeng Kai , Feng Jianwei , Lin Lin , Wei Yuntao , Kato Shigeaki , Zhang Qiang , Zhao Yue 
Published: December 2023

AbstractEndocrine resistance is a crucial challenge in estrogen receptor alpha (ERα)-positive breast cancer (BCa). Aberrant alteration in modulation of E2/ERα signaling pathway has emerged as the putative contributor for endocrine resistance in BCa. Herein, we demonstrate that MYSM1 as a deubiquitinase participates in modulating ERα action via histone and non-histone deubiquitination. MYSM1 is involved in maintenance of ERα stability via ERα deubiquitination. MYSM1 regulates relevant histone modifications on cis regulatory elements of ERα-regulated genes, facilitating chromatin decondensation. MYSM1 is highly expressed in clinical BCa samples. MYSM1 depletion attenuates BCa-derived cell growth in xenograft models and increases the sensitivity of antiestrogen agents in BCa cells. A virtual screen shows that the small molecule Imatinib could potentially interact with catalytic MPN domain of MYSM1 to inhibit BCa cell growth via MYSM1-ERα axis. These findings clarify the molecular mechanism of MYSM1 as an epigenetic modifier in regulation of ERα action and provide a potential therapeutic target for endocrine resistance in BCa.
The presence of a G-quadruplex prone sequence upstream of a minimal promoter increases transcriptional activity in the yeast Saccharomyces cerevisiae
Authors: Kratochvilová Libuše , Vojsovič Matúš , Valková Natália , Šislerová Lucie , El Rashed Zeinab , Inga Alberto , Monti Paola , Brázda Václav 
Published: December 2023

Abstract
Non-canonical secondary structures in DNA are increasingly being revealed as critical players in DNA metabolism, including modulating the accessibility and activity of promoters. These structures comprise the so-called G-quadruplexes (G4s) that are formed from sequences rich in guanine bases. Using a well-defined transcriptional reporter system, we sought to systematically investigate the impact of the presence of G4 structures on transcription in yeast Saccharomyces cerevisiae. To this aim, different G4 prone sequences were modeled to vary the chance of intramolecular G4 formation, analyzed in vitro by Thioflavin T binding test and circular dichroism and then placed at the yeast ADE2 locus on chromosome XV, downstream and adjacent to a P53 response element (RE) and upstream from a minimal CYC1 promoter and Luciferase 1 (LUC1) reporter gene in isogenic strains. While the minimal CYC1 promoter provides basal reporter activity, the P53 RE enables LUC1 transactivation under the control of P53 family proteins expressed under the inducible GAL1 promoter. Thus, the impact of the different G4 prone sequences on both basal and P53 family protein-dependent expression was measured after shifting cells onto galactose containing medium. The results showed that the presence of G4 prone sequences upstream of a yeast minimal promoter increased its basal activity proportionally to their potential to form intramolecular G4 structures; consequently, this feature, when present near the target binding site of P53 family transcription factors, can be exploited to regulate the transcriptional activity of P53, P63 and P73 proteins.
Der Zusammenhang von sozialen und familiären Strukturen mit
Verhaltensauffälligkeiten bei Vorschulkindern
Authors: Hmayed Samir , Thyen Ute 
Published: December 2023

Zusammenfassung
Hintergrund Verhaltensauffälligkeiten bei Kindern sind eine
mögliche Symptomausprägung psychischer Störungen und
Zeichen eingeschränkter mentaler Gesundheit. Ihre Ausprägung
wird von familiären und sozialen Faktoren beeinflusst, wobei wenig
über die Interaktionen von Familienstruktur, Bildungsstatus,
Migrationshintergrund und Erwerbstätigkeit im Hinblick auf
Verhaltensauffälligkeiten bekannt ist. Diese Zusammenhänge
wurden in einer repräsentativen Stichprobe 5–6 jähriger
Kinder untersucht.
Methoden Die Datenerhebung (n=15.271) erfolgte zwischen September
2018 und August 2019 in ganz Schleswig-Holstein im Rahmen der
Schuleingangsuntersuchungen. Erfasst wurden Verhaltensauffälligkeiten
der Kinder mittels eines Screening-Fragebogens für Eltern, dem Strengths
and Difficulties Questionnaire (SDQ). Die statistischen Untersuchungen umfassten
deskriptive Analysen, sowie die Berechnung eines bivariaten logistischen
Regressionsmodells mit den dichotomen Endpunkten des SDQ
„auffällig“ und „unauffällig“
als abhängige und sozialen und familiären Faktoren als
unabhängige Variablen (Geschlecht, Familienstruktur, Geschwisteranzahl,
Sprachpraxis, Migrationshintergrund, familiärer Bildungsstand,
elterliche Erwerbsarbeit und regelmäßiger Sport in einem
Sportverein).
Ergebnisse Die statistischen Analysen mittels logistischer Regression
zeigten, dass Kinder, die bei Alleinerziehenden lebten, eine 2,1-fach (Odds
Ratio; OR) höhere Chance hatten [95%-KI: 1,7–2,6]
Verhaltensauffälligkeiten zu zeigen, als Kinder, die bei beiden
leiblichen Elternteilen lebten. Einzelkinder hatten eine 1,4-fach höhere
Chance [95%-KI: 1,2–1,8] gegenüber Kindern, die mit
einem oder zwei Geschwisterkindern aufwuchsen. Kinder mit einseitigem
Migrationshintergrund zeigten eine niedrigere Chance für
Verhaltensauffälligkeiten [OR: 0,58; 95%-KI: 0,38–0,87]
als Kinder ohne Migrationshintergrund. Kinder aus Familien mit niedrigem
Bildungsstand hatten eine 3-fach höhere Chance für
Verhaltensauffälligkeiten [95%-KI: 2,3–3,8]
gegenüber Kindern aus Familien mit hohem Bildungsstand. Waren beide
Elternteile (bzw. die alleinerziehende Person) mindestens in Teilzeit
erwerbstätig, zeigte sich eine niedrigere Chance für
Verhaltensauffälligkeiten [OR: 0,58; 95%-KI:0,47–0,71]
des Kindes verglichen mit Kindern, bei denen mindestens ein Elternteil
erwerbslos war.
Schlussfolgerungen Diese Studie konnte soziodemografische Faktoren
identifizieren, die mit der Ausprägung von
Verhaltensauffälligkeiten assoziiert sind. Insbesondere
Alleinerziehende, Familien mit geringen Bildungsabschlüssen und
Familien, in denen mindestens ein Elternteil erwerblos ist, sollten adressiert
werden.
Biomechanical Comparison of Uniplanar versus Biplanar Lateral Opening-wedge Distal Femoral Osteotomy Techniques in Terms of Risk for Medial Hinge Fracture
Authors: Yıldırım Cem , Demirel Mehmet , Ekinci Mehmet , Öztürk Simge , Bozdağ Süreyya Ergün 
Published: December 2023

AbstractThe effect of osteotomy type on the initial stiffness of the bone-implant construct in lateral opening-wedge distal femoral osteotomy (LOWDFO) using a uniplanar compared with a biplanar technique has been investigated. However, no study has explored the biomechanical risk factors for medial hinge fracture. This study aimed to compare the biomechanical strength of uniplanar versus biplanar LOWDFO regarding the risk for medial hinge fracture during gap opening. Twelve composite femora were divided into two groups (six in each group) based on the distal femoral osteotomy technique: uniplanar versus biplanar LOWDFO. All LOWDFO models were subjected to incremental static loading. The gap distance was expanded by 1 mm, and displacement values were recorded as anterior and posterior gap distances (mm). The average force values of all samples at certain gap distances were recorded, and the head distance was measured. The uniplanar group had higher load values than the biplanar group at all anterior gap distances. These differences were only significant at 2- and 3-mm gap distances (p = 0.025 and 0.037). At all posterior gap distances, the uniplanar group had higher load values than the biplanar group, but these differences only reached statistical significance at 2 mm (p = 0.037). Both groups had similar anterior, posterior, and average gap distances (p = 0.75, 0.522, 0.873). The uniplanar group had a higher head insertion distance (15.3 ± 5.7) than the biplanar group (14.7 ± 2.9), but it was not significant (p = 0.87). The uniplanar group had a lower average load before medial hinge fracture (46.41 ± 13.91 N) than the biplanar group (54.92 ± 31.94, p = 0.81). The biplanar group had an average maximum load value of 64.18 ± 25.6 N, while the uniplanar group had 57.90 ± 12.21 N (p = 0.81). This study revealed that the biplanar osteotomy technique allows a wider opening wedge gap with less risk of a medial hinge fracture than uniplanar LOWDFO.Level of evidence was level 3, case–control series.
Early Surgical Management of Medial Patellar Luxation in Juvenile Dogs
Authors: Carrera Alefe L.C. , Minto Bruno W. , Curuci Eloy H.P. , Paula Carla G. , Jassniker Julia B. , Cunha Olicies 
Published: December 2023

AbstractThe aim of this study was to analyse a series of five cases of early surgical treatment in juvenile canine patients with high-grade medial patellar luxation. Canine patients, with immature skeleton, affected by grade III or IV medial patellar luxation and treated by multimodal surgical techniques were selected. Five dogs of different breeds, mean age 7.2 ± 3.0 months, met the inclusion criteria. Simultaneous distal femoral varus and external tibial torsion were identified in three of the five cases, whereas in the others, femoral varus with associated tibial valgus and isolated external tibial torsion were observed. Four of the five patients were treated surgically with closing wedge osteotomy of the distal femur, and three of them underwent tibial tuberosity transposition simultaneously. Only two animals required trochleoplasty. Mean time to beginning of weight bearing was 9.8 ± 5.5 days, whereas time to bone healing was 55 ± 24 days. Bone realignment of the extensor apparatus and return to limb support were achieved in all cases. Postoperative reintervention was needed in one patient; however, it was not linked to the initial surgery. Patients were followed up to 1 year postoperatively, with maintenance of extensor alignment and no late complications. The early surgical approach has been shown to be effective in the definitive treatment of juvenile dogs affected by high-grade medial patellar luxation.
Prevalence of Postnatal Depression in Fathers: A Systematic Review and Meta-Analysis
Authors: Dhanpal H N , Shil Rahul 
Published: December 2023

Abstract
Background and Aim Postnatal depression (PND) can affect both genders, but the common misconception is that it only affects mothers. Increasing literature reports that 10% of the fathers experience PND after childbirth. This systematic review and meta-analysis aim to determine the pooled estimated prevalence of PND among fathers in the postnatal period and identify its risk factors.
Materials and Methods The electronic databases PubMed, ProQuest, BASE, DOAJ, ResearchGate, Semantic Scholar, and BioMed Central were searched for related open-access articles published between January 2010 and March 2021. Finally, 15 articles met inclusion criteria. A random-effects model was used to calculate pooled estimates and 95% confidence intervals.
Results The pooled prevalence of PND in fathers was 24.06%. Partner's depression, lack of social support, poor marital relationship, low income, and low education were all shown to raise the risk of PND in fathers.
Conclusion PND in fathers is a serious concern. Early identification and treatment decrease the detrimental impact on mother and child while further improving quality of life.
Considerations in the Treatment of Depression and Anxiety in Women with PCOS
Authors: Alur-Gupta Snigdha , Dokras Anuja 
Published: December 2023

AbstractWomen with polycystic ovary syndrome (PCOS) are known to be at a greater risk of depression and anxiety. What is less clear is whether existing treatments for PCOS are effective in managing this increased risk and what the optimal approach to treatment is. In this review, currently available interventions are explored including lifestyle modifications, oral contraceptives, insulin sensitizing agents, psychosocial interventions and psychiatric medications. While data are often conflicting, lifestyle interventions, and cognitive behavioral therapy (CBT) appear most promising in reducing depression and anxiety symptoms in this population. There is an urgent need for large prospective studies to fill gaps in the literature.
Beyond triviality barriers: the transcendent poetics of play in Feng Zikai’s manhua legacy
Authors: You Chengcheng 
Published: December 2023

AbstractDespite the socio-political upheavals that marked twentieth-century China, Feng Zikai (豐子愷,1898–1975), a Chinese artist and writer, invariably figures his art forms with child subjects in ways that encapsulate a childhood idyll reminiscent of the ancient genre of painting children at play. Drawing from Feng’s manhua anthology, this study delves into the multimodal representations of children’s play to uncover the intertwined social, aesthetic, and ethical discourses within the context of modern China. It posits that Feng’s manhua legacy embodies a transcendent poetics of play by integrating the elemental functions and indigenous aesthetics of play. Three aspects of transcendence arise from the paradoxical nature of play, Feng’s compassionate outlook, and the imaginative materialisation of cultural heritage along with its contemporary relevance, illuminating the interplay between Feng’s artistic journey and the constantly evolving socio-political context in which it unfolds.
The early Baba Malay continuum
Authors: Lee Nala H. 
Published: December 2023

Abstract
Baba Malay today is an endangered creole perceived to be a less flexible, easily identifiable language entity with static ascribed qualities. An investigation of resources from the late 1800s and early 1900s shows that such a characterization of early Baba Malay is not possible. Three novels and twenty letters demonstrate a wide range of variation, lexically and grammatically, emphasizing a wide creole continuum that plausibly existed in the heydays of the language. The wide range of variation can be understood to be detracting from, and aligning with the creole’s substrate and lexifier languages, or with the language that was gaining dominance during that time, English. The linguistic ideologies of early Baba Malay speakers and competing pressures in their group identities explain the considerable variation found.
Prioritizing Animal Welfare in AAI Hospital Programs
Authors: Foss Cynnie H.E. 
Published: December 2023

Abstract
A successful animal-assisted intervention (AAI) program in a hospital setting must include careful planning and monitoring. It requires in-depth knowledge of the hospital environment, training for teams beyond what is provided through registering agencies, understanding animal welfare needs and indicators, training all involved staff and volunteers, and prioritizing the safety of all involved. There is a need for AAI organizations to create standards of practice and offer professional certifications to cultivate legitimacy for AAI programs and ensure that all participants realize that animal welfare is paramount for successful and sustainable programs in a healthcare environment and beyond. These issues are explored in the following case report with examples given to help illustrate the unique aspects that must be considered when implementing AAI in a hospital setting.

Information
© The Author 2023
Understanding and managing seed degeneration in potato: Implications for potato resilient seed system and food security. A review
Authors: Tessema Lemma , Tesfaye Mamaru 
Published: December 2023

Abstract
Understanding seed degeneration in potato farming systems requires updated and pertinent information across different cropping systems and circumstances to find ways to deal with the problem. As a vegetatively propagated crop, potato is susceptible to pathogens and pest accumulation in seed tubers over successive cycles of vegetative propagation especially, where small-scale farmers replant their source seed for several production seasons. Seed degeneration in potatoes is a complex phenomenon, caused by a variety of soil, vector, and seed-borne pathogens resulting reduction in yield and quality of the crop. By providing an extensive overview of the current state of knowledge on the impacts and coping strategies of potato seed degeneration, mostly in the global south, this review aims to help underpin such relevant information and better development of the seed sector. This review article also provides insights on seed system bottlenecks leading to seed degeneration which impact food security and the livelihoods of smallholder farmers in developing countries including Ethiopia. We discussed the causes of seed degeneration and possible approaches to conquer the problem under smallholders’ perspective for sustainable potato production and improved food security.
The political economy of the climate crisis in Southern Africa
Authors: Mkodzongi Grasian 
Published: December 2023

ABSTRACT
This article maps out the dynamics of the climate crisis that is unfolding globally, but whose consequences have a disproportionate impact on countries in sub-Saharan Africa and the wider global South. Although these countries have contributed insignificant amounts of greenhouse gas emissions (compared to their industrialised counterparts), their populations are the major victims of climate change, whose disastrous impacts were recently witnessed in Zimbabwe during Cyclone Idai and in South Africa during the Durban floods. In addition, Southern Africa is experiencing climate change-induced droughts, depleting water in major dams and undermining hydroelectric power generation, especially in Zambia and Zimbabwe. As a result, the region is experiencing dangerous power outages affecting agriculture and other key industries. This article adopts a novel decolonial perspective to make sense of these extreme weather events, arguing that the climate crisis is already affecting the livelihoods of many people in Southern Africa and that it is often the poor and vulnerable who suffer most from the impacts of climate change. There is thus a need for industrialised countries to contribute towards the costs of climate change mitigation since they are historically responsible for most of the carbon emissions.
Autonomous projects in the face of the global fishing market: women fish processors in Senegal in a context of climate emergency
Authors: Moreno-Maestro Susana 
Published: December 2023

ABSTRACT
This article aims to analyse the difficult relationship between the needs of the Senegalese state to obtain economic compensation for the over-exploitation of natural resources, the right to food sovereignty of the local population, and the survival of the environment. It focuses on the fisheries agreements signed by Senegal with the European Union (EU) and how these have an impact on the conditions of people who make a living from the sector, analysing the situation and the self-organising of women involved in fish processing, an activity that sustains their autonomy and their ongoing reproduction as a collective. Declared goals of sustainable fishing in the latest protocol implementing the EU–Senegal Fisheries Agreement (2019–2024) are at odds with the actual over-exploitation of the marine environment. The commitment expressed in Article 2 of the agreement to ‘promote sustainable fishing and protect marine biodiversity’ contrasts with the lived experiences of women fish processors, expressed in denunciations of campaigns such as Greenpeace Afrique’s AnaSamaJën (where is my fish?). Based on the assumption that overfishing is a form of extractivism that undermines food sovereignty and the sustainability of local societies, this article first analyses the agreements signed between Senegal and the EU, including their clear anthropocentric ontology (Escobar 2017) and discusses how the state takes up the financial, environmental and food challenges posed by climate change. The second part, based on fieldwork and interviews with women fish processors and other actors in the sector, shows how these international agreements affect their economic and social conditions as well as their resistance, where social struggles and environmental thinking are linked.
Heusler-alloy-based magnetoresistive sensor with synthetic antiferromagnet
Authors: Khamtawi R , Saenphum N , Chantrell R W , Chureemart J , Chureemart P 
Published: December 2023

Abstract
Heusler alloy has been widely utilized in magnetoresistive sensors to enhance the device performance. In this work, we theoretically investigate the performance of Heusler-alloy-based magnetoresistive sensors with a synthetic antiferromagnet (SAF) layer. The atomistic model combined with the spin accumulation model will be used in this work. The former is used to construct the reader stack and investigate the magnetization dynamics in the system. The latter is employed to describe the spin transport behavior at any position of the structure. We first perform simulations of the exchange bias (EB) phenomenon in the IrMn/

C

o
2

F
e
S
i

(CFS) system providing a high EB field. Then, a realistic reader stack of IrMn/CFS/Ru/CFS/Ag/CFS is constructed via an atomistic model. Subsequently, the resistance–area product (RA) and magnetoresistance (MR) ratio of the reader can be calculated by using the spin accumulation model. As a result of the spin transport behavior in the Heusler-alloy-based reader stack including SAF structure at 0 K, an enhancement of the MR ratio up to 120

%

and RA

<
40
m

Ω
⋅
μ

m
2

can be observed. This study demonstrates the important role of the Heusler alloy and SAF layer in the development of magnetoresistive sensors for the application of readers in hard disk drives with an areal density beyond 2 Tb in−2.
Enhanced ultraviolet photo-detecting by constructing TiO2/KNbO3 heterojunction
Authors: Song Jianqiao , Bai Zhaowen , Wang Gang , Li Jiang , Zhang Xinmiao , Jin Mengjing , Zhao Haixing , Chang Peng , Pan Xiaojun 
Published: December 2023

Abstract
The demands of the ultraviolet (UV) radiation monitoring is rising in fields of human health and survival surroundings. Among many types of UV detectors, the photoelectrochemical (PEC) type UV detectors based on solar sensitized cells have gained a lot attention because of their fast response, low cost, simple manufacturing process, self-powered and so on. The heterojunction can accelerate the separation and migration of photogenerated carriers and then improve the photoresponse of UV detectors. In this work, the nanostructure KNbO3 (KNO) films were modified by chemical bath deposition to form a TiO2/KNO heterojunction. Compared with the UV detectors based on pure KNO and TiO2, the responsivity of the developed PEC UV photodetectors based on TiO2/KNO reached 11.99 mA W−1 under UV illumination of 35 mW cm−2 @ 365 nm, which is higher than that of the pure KNO UV detector (1.26 mA W−1) and the TiO2 UV detector (3.96 mA W−1). Besides, the lifetime of photogenerated carrier, response time and recovery time of the detector are all promoted. The results can be attributed to the formation of a TiO2/KNO heterojunction, in which the generated built-in electric field can promote the separation of photogenerated carriers and hinder the recombination of photogenerated electron–hole pairs, thus improving the detection performance of the UV detectors.