bluuebunny/crossref_metadata_2025_split huggingface dataset:
Subtype-specific role for Jagged1 in promoting or inhibiting breast tumor formation
Authors: Chung Wen-Cheng , Wang Wei , Challagundla Lavanya , Moore Charles D. , Egan Sean E. , Xu Keli 
Published: January 2025

Abstract
Notch signaling is altered in breast cancer. Recent studies highlighted both tumor-suppressive and oncogenic roles for Notch in this tissue. The function of Jagged1, the most highly expressed Notch ligand in the mammary gland, is not well defined. Here we report that deletion of Jagged1 in the mammary epithelium of virgin mice led to expansion of the mammary stem cell (MaSC) compartment and defective luminal differentiation associated with decreased expression of the progesterone receptor (PR). In contrast, deletion of Jagged1 in alveolar cells of pregnant mice had no effect on alveolar and lactogenic differentiation or post-lactational involution. Interestingly, deletion of Jagged1 promoted mouse mammary tumor formation from luminal cells but suppressed them from basal cells, associated with downregulation of Notch target genes Hey1 and Hey2, respectively. In agreement with mouse experiments, high expression of JAG1 and HEY1 are associated with better overall survival among patients with luminal tumors, whereas high expression of JAG1 and HEY2 are both associated with worse overall survival in basal subtype of human breast cancer. These results identified Jagged1 as an important regulator of mammary epithelial hierarchy and revealed differential roles of Jagged1-mediated Notch signaling in different subtypes of breast cancer arising from distinct cell types.
European training requirements in Neonatology 2021—towards a unified training standard for Neonatologists
Authors: Roehr Charles C. , Wellmann Sven , Szczapa Tomasz , Fentsch Pascal , Hüppi Petra , Baud Olivier , Alarcon Ana , de Boode Willem P. , Hall Michael , Danhaive Olivier , Vento Maximo ,   On behalf of the European Society for Paediatric Research (ESPR), the European Board of Neonatal & Child Health Research (EBNCHR) and the European School of Neonatology (ESN)
Published: January 2025

Abstract
The European Society for Paediatric Research (ESPR) first developed recommendations for a Neonatology specific European training curriculum in 1998, with updates in 2007 and 2021. The aim of these recommendations was to define a common, European standard of training for national educational programmes for Neonatologists. Following the Union of European Medical Specialists’ (UEMS) framework of European Training Requirements (ETR), and similar to the American Board of Pediatrics (ABP) recommendations, graduates of training programmes conforming to the ETR will be eligible throughout Europe for recognition of equality of training, and with that should be enabled to freedom-of-movement. This concept also accounts for neonatal specialists. We therefore present the pan-European work on the ETR Neonatology in its third iteration (ETR III), summarising the basic requirements for contemporary training programmes, trainers, and training centres in neonatology. We highlight the European School of Neonatology (ESN) as a comprehensive online educational platform which provides the theoretical and practical background to satisfy the ETR-III. Lastly, we introduce the European Board of Neonatal & Child Health Research (EBNCHR) as a committee dedicated to gaining acceptance for the concept of harmonising education and training in Neonatology and recognising Neonatology as a Paediatric subspecialty in every European Union member state.

Impact

Neonatology currently is not uniformly recognised as a Paediatric subspecialty throughout the 27 European countries. Hence, training in Neonatology formerly followed no commonly agreed standard throughout the European Union (EU).

To ensure a minimum standard of care, an agreed minimum standard of training is required. The European Society for Paediatric Research (ESPR) has led on generating an EU-accredited, pan-European Syllabus for Neonatal training in Europe, the European Training Requirements (ETR) in Neonatology (2021).

This article presents the ETR Neonatology from commissioning to accreditation and discusses means of how high-grade post-graduate education, aligned with the ETR can be achieved by practitioners.
Regulatory roles of RNA binding proteins in the Hippo pathway
Authors: Peng Shuchang , Li Chenglin , He Yanwen , Xue Lei , Guo Xiaowei 
Published: January 2025

Abstract
The Hippo pathway represents a highly conserved evolutionary pathway, dysfunction of which has been implicated in various diseases. RNA-binding proteins (RBPs) intricately modulate gene expression through interacting with non-coding RNAs or other proteins. To data, while an array of RBPs have been identified as modulators of the Hippo pathway, there remains a notable absence of a comprehensive review addressing the mechanistic regulations of RBPs in the transduction of Hippo signaling. Herein, this review aims to consolidate recent advances and elucidate the intricate mechanisms underlying RBPs binding to target RNA. It also explores the dynamic interplay between RBPs, non-coding RNAs, TFs, and DNA on chromatin. Additionally, it also outlines future perspectives, including the essential non-canonical functions of RBPs and emerging roles of non-canonical RBPs as transcription factors (TFs) in genes transcription. Overall, this review provides mechanistic insights into the roles of eukaryotic RBP proteins in the regulation of crucial signaling cascades.
Regeneration in the absence of canonical neoblasts in an early branching flatworm
Authors: Gąsiorowski Ludwik , Chai Chew , Rozanski Andrei , Purandare Gargi , Ficze Fruzsina , Mizi Athanasia , Wang Bo , Rink Jochen C. 
Published: January 2025

Abstract
The remarkable regenerative abilities of flatworms are closely linked to neoblasts – adult pluripotent stem cells that are the only division-competent cell type outside of the reproductive system. Although the presence of neoblast-like cells and whole-body regeneration in other animals has led to the idea that these features may represent the ancestral metazoan state, the evolutionary origin of both remains unclear. Here we show that the catenulid Stenostomum brevipharyngium, a member of the earliest-branching flatworm lineage, lacks conventional neoblasts despite being capable of whole-body regeneration and asexual reproduction. Using a combination of single-nuclei transcriptomics, in situ gene expression analysis, and functional experiments, we find that cell divisions are not restricted to a single cell type and are associated with multiple fully differentiated somatic tissues. Furthermore, the cohort of germline multipotency genes, which are considered canonical neoblast markers, are not expressed in dividing cells, but in the germline instead, and we experimentally show that they are neither necessary for proliferation nor regeneration. Overall, our results challenge the notion that canonical neoblasts are necessary for flatworm regeneration and open up the possibility that neoblast-like cells may have evolved convergently in different animals, independent of their regenerative capacity.
Single-cell profiling of penta- and tetradactyl mouse limb buds identifies mesenchymal progenitors controlling digit numbers and identities
Authors: Palacio Victorio , Pancho Anna , Morabito Angela , Malkmus Jonas , He Zhisong , Soussi Geoffrey , Zeller Rolf , Treutlein Barbara , Zuniga Aimée 
Published: January 2025

Abstract
The cellular interactions controlling digit numbers and identities have remained largely elusive. Here, we leverage the anterior digit and identity loss in Grem1 tetradactyl mouse limb buds to identify early specified limb bud mesenchymal progenitor (LMP) populations whose size and distribution is governed by spatial modulation of BMP activity and SHH signaling. Distal-autopodial LMPs (dLMP) express signature genes required for autopod and digit development, and alterations affecting the dLMP population size prefigure the changes in digit numbers that characterize specific congenital malformations. A second, peripheral LMP (pLMP) population is anteriorly biased and reduction/loss of its asymmetric distribution underlies the loss of middle digit asymmetry and identities in Grem1 tetradactyl and pig limb buds. pLMPs depend on BMP activity, while dLMPs require GREM1-mediated BMP antagonism. Taken together, the spatial alterations in GREM1 antagonism in mouse mutant and evolutionarily diversified pig limb buds tunes BMP activity, which impacts dLMP and pLMP populations in an opposing manner.
Resolving active species during the carbon monoxide oxidation over Pt(111) on the microsecond timescale
Authors: Eads Calley N. , Wang Weijia , Küst Ulrike , Prumbs Julia , Temperton Robert H. , Scardamaglia Mattia , Schnadt Joachim , Knudsen Jan , Shavorskiy Andrey 
Published: January 2025

Abstract
Catalytic studies traditionally rely on steady-state conditions resulting in time-averaged datasets that do not differentiate between active and spectator species. This limitation can cause misinterpretations of catalytic function, as the signal of short-lived intermediates responsible for producing desired reaction products is often masked by more intense spectator species. Time-resolved ambient pressure X-ray photoelectron spectroscopy (tr-APXPS) mitigates this issue by combining microsecond time resolution under reaction conditions. Using tr-APXPS, we investigate the oxidation of CO over Pt(111) by concurrently tracking reaction products, surface intermediates, and catalyst response. Our findings reveal that chemisorbed oxygen, rather than Pt surface oxide, is the main species reacting with CO to form CO2, supporting a primary Langmuir-Hinshelwood mechanism. The results shed new light on a heavily-debated reaction in catalysis. Beyond using CO pulses to determine active species, we demonstrate how careful tuning of pulsing parameters can be used for dynamic catalyst operation to enhance CO2 formation.
Accelerated symptom improvement in Parkinson’s disease via remote internet-based optimization of deep brain stimulation therapy: a randomized controlled multicenter trial
Authors: Gharabaghi Alireza , Groppa Sergiu , Navas-Garcia Marta , Schnitzler Alfons , Muñoz-Delgado Laura , Marshall Vicky L. , Karl Jessica , Zhang Lin , Alvarez Ramiro , Feldman Mary S. , Soileau Michael J. , Luo Lan , Zauber S. Elizabeth , Walter Benjamin L. , Wu Chengyuan , Lei Hong , Herz Damian M. , Chung Ming-Hua , Pathak Yagna , Blomme Bram , Cheeran Binith , Luca Corneliu , Weiss Daniel 
Published: January 2025

Abstract

Background
Deep brain stimulation (DBS) has emerged as an important therapeutic intervention for neurological and neuropsychiatric disorders. After initial programming, clinicians are tasked with fine-tuning DBS parameters through repeated in-person clinic visits. We aimed to evaluate whether DBS patients achieve clinical benefit more rapidly by incorporating remote internet-based adjustment (RIBA) of stimulation parameters into the continuum of care.

Methods
We conducted a randomized controlled multicenter study (ClinicalTrails.gov NCT05269862) involving patients scheduled for de novo implantation with a DBS System to treat Parkinson’s Disease. Eligibility criteria included the ability to incorporate RIBA as part of routine follow-up care. Ninety-six patients were randomly assigned in a 1:1 ratio using automated allocation, blocked into groups of 4, allocation concealed, and no stratification. After surgery and initial configuration of stimulation parameters, optimization of DBS settings occurred in the clinic alone (IC) or with additional access to RIBA. The primary outcome assessed differences in the average time to achieve a one-point improvement on the Patient Global Impression of Change score between groups. Patients, caregivers, and outcome assessors were not blinded to group assignment. Most of the data collection took place in the patient’s home environment.

Results
Access to RIBA reduces the time to symptom improvement, with patients reporting 15.1 days faster clinical benefit (after 39.1 (SD 3.3) days in the RIBA group (n = 48) and after 54.2 (SD 3.7) days in the IC group (n = 48)). None of the reported adverse events are related to RIBA.

Conclusions
This study demonstrates safety and efficacy of internet-based adjustment of DBS therapy, while providing clinical benefit earlier than in-clinic optimization of stimulation parameters by increasing patient access to therapy adjustment.
Immunomediated Encephalitis: New Diagnoses on the Neurology–Psychiatry Interface
Authors: Damiani Daniel , de Bem Aline Ribeiro 
Published: January 2025

AbstractImmune-mediated encephalitis is a real diagnostic challenge. Initially, patients present with subacute behavioral alterations, evolving over months, being attributed to purely psychiatric mechanisms, as well as neurological symptoms that often go unnoticed by professionals who are not neurologists. The etiologies behind these diseases are represented by paraneoplastic syndromes (including occult tumors) as well as viral infections, in both cases constituting true immunological triggers with exposure of antigens that will lead to a cross-immunological response directed at healthy structures of the nervous system. In the current review, we present the different clinical scenarios which differ based on antibodies against membrane receptors described so far, emphasizing the relevance of an early diagnosis for a smaller impact on prognosis.
On care, chocolate cake, and challenging with love
Authors: Shepherd Laura J. 
Published: January 2025

Abstract
This essay responds to the contributions that make up this forum, which in turn represent the authors’ engagement with my recent book, The Self, and Other Stories: Being, Knowing, Writing (Rowman and Littlefield, 2023). I attempt to answer some of the queries that arise for my interlocutors and to elaborate on some of the themes that I touch on in the book itself. I am not sure I am very successful in either endeavour, because the queries are many and I feel far removed from the book at this stage, but here we are.
The self-attractive ultralight axion and its time scale of collapsing in general relativistic framework
Authors: Fukuyama Takeshi 
Published: January 2025

Abstract
The formation of supermassive black holes (SMBHs) at high redshift z by ultralight axion dark matter (DM) is discussed in the general relativistic framework.
The critical condition of collapsing of self-attracting DM in non-relativistic treatment corresponds to dust particle, which allows to estimate the time scale of the SMBH formation and the its length scale in the general relativistic framework. It gives the support of ultralight axion model based on the string model as the origins of the early universe SMBH and the Little Red Dots (LRDs) etc. observed by James Webb Space Telescope (JWST).
Neutrino cosmology after DESI: tightest mass upper limits, preference for the normal ordering, and tension with terrestrial observations
Authors: Jiang Jun-Qian , Giarè William , Gariazzo Stefano , Dainotti Maria Giovanna , Di Valentino Eleonora , Mena Olga , Pedrotti Davide , Santos da Costa Simony , Vagnozzi Sunny 
Published: January 2025

Abstract
The recent DESI Baryon Acoustic Oscillation measurements have led to tight upper limits on the neutrino mass sum, potentially in tension with oscillation constraints requiring ∑ mν
≳ 0.06 eV. Under the physically motivated assumption of positive ∑ mν
, we study the extent to which these limits are tightened by adding other available cosmological probes, and robustly quantify the preference for the normal mass ordering over the inverted one, as well as the tension between cosmological and terrestrial data. Combining DESI data with Cosmic Microwave Background measurements and several late-time background probes, the tightest 2σ limit we find without including a local H
0 prior is ∑ mν
< 0.05 eV. This leads to a strong preference for the normal ordering, with Bayes factor relative to the inverted one of 46.5. Depending on the dataset combination and tension metric adopted, we quantify the tension between cosmological and terrestrial observations as ranging between 2.5σ and 5σ. These results are strenghtened when allowing for a time-varying dark energy component with equation of state lying in the physically motivated non-phantom regime, w(z) ≥ -1, highlighting an interesting synergy between the nature of dark energy and laboratory probes of the mass ordering. If these tensions persist and cannot be attributed to systematics, either or both standard neutrino (particle) physics or the underlying cosmological model will have to be questioned.
Research on objective evaluation methods for air conditioning sound quality
Authors: Li Bin , Yang Sijia , Qiu Xiangyu , Wang Jun 
Published: January 2025

Abstract
With the continuous reduction of air conditioning noise, sound quality has become a new important research direction in air conditioning. This paper establishes a subjective evaluation method for sound quality based on the reference scoring method through multiple comparative studies, resulting in higher timeliness and accuracy of evaluation results. By analyzing the sensitivity of objective evaluation parameters for sound quality, including A-weighted sound level, loudness, sharpness, roughness, speech clarity, and prominence ratio, objective evaluation models for sound quality were developed using multiple linear regression analysis and neural network algorithms. The conformity of both objective evaluation models with the subjective evaluation results for sound quality reached approximately 90%, with the neural network modeling method showing slightly higher accuracy than the linear regression analysis method.
Study on three-dimensional background normalization based on continuous active sonar
Authors: Lu Shiyu , Li Dongyang , Ding Feng 
Published: January 2025

Abstract
Background normalization is one of the hot fields in underwater acoustic signal processing. Building on the conventional two-dimensional background normalization methods, this paper extends these techniques to three dimensions, tailored for the high-dimensional characteristics of continuous active sonar detection data. The three-dimensional background normalization algorithm sets protection windows and reference windows in the azimuth, range, and Doppler directions, and then uses the data from the reference windows to estimate the background power of the test cell. This paper analyzes and verifies the performance of the three-dimensional background normalization detection algorithm using simulated continuous active sonar detection data. The result shows that, compared to traditional two-dimensional background normalization detection algorithms, the three-dimensional background normalization detection algorithm performs better in complex backgrounds.
Study on the effect of acoustic scattering on the performance of close-packed array elements
Authors: Xin Tan , Quan Liang , Yuan Gao , Lei Wang 
Published: January 2025

Abstract
Currently, with the continuous advancement of underwater robotic systems and technologies, the associated acoustic payloads are required to develop towards miniaturization and multifunctional integration. In the design and application of acoustic systems, the effects of acoustic scattering and the resulting performance degradation cannot be ignored. To address this issue, this paper constructs a finite element model of densely packed array elements’ acoustic scattering in a dual circular ring array design using finite element software. Based on the model simulations of sound waves at different frequencies, the disturbance of the array elements’ acoustic scattering on the received sound field is discussed. Further analysis is conducted on the mutual scattering effects between array elements and their impact on the performance of individual hydrophones. The simulation results show that within the frequency range of 1-100 kHz, there is significant scattering between small-sized array elements, with the scattered sound pressure level increasing linearly with frequency. Under given array parameters, the change in hydrophone reception performance is mainly due to the scattering effects of array elements in the normal direction of the hydrophone, and is related to the incident direction of the sound wave.
Numerical research on droplet formation in T-shaped microchannel using the lattice Boltzmann method
Authors: Cai Shengchuan , Dong Min , Qi Susu , Liu Jinglei 
Published: January 2025

Abstract
The droplet dynamics in the microchannels are exceptionally sophisticated, and there are many factors that can affect the formation, motion and interaction of micro-droplets. The insufficient understanding of the flow mechanism in microchannels has become a primary constraint to the development of efficient micro-droplet equipment. This paper focuses on the microscale multiphase flow, using the two-phase lattice Boltzmann model and numerical methods to conduct research on the mechanism and process of droplet formation inside T-shaped microchannels. It is demonstrated that the formation of droplets presents three stages: the entering stage, formation stage and shedding stage. With the variation of Ca number, the droplet formation manifests in three different modes: squeezing mode, dripping mode and jetting mode. When the flow ratio remains constant, the droplet length decreases with the increase of Ca number, and the interface fracture position moves downstream.
Network analysis of memristive device circuits: dynamics, stability andcorrelations
Authors: Barrows Frank , Caravelli Francesco , Sheldon Forrest 
Published: January 2025

Abstract
Networks with memristive devices are a potential basis for the next generation of computing devices. They are also an important model system for basic science, from modeling nanoscale conductivity to providing insight into the information-processing of neurons. The resistance in a memristive device depends on the history of the applied bias&#xD;
Facticity and the Fate of Reason After Kant
Authors: Bruno G Anthony 
Published: January 2025

Abstract
Facticity and the Fate of Reason After Kant is the first history of the concept of facticity. It shows that this concept’s coining, transmission, and repurposing by post-Kantian thinkers leaves a lasting divide concerning the question of whether a science of intelligibility can tolerate brute facts. ‘Facticity’ is associated with phenomenology, for which it denotes undeducibly brute conditions of intelligibility. While this suggests an affirmative answer to the post-Kantian question, ‘facticity’ originates with German idealism, whose proponents answer negatively. Fichte coins ‘facticity’ to denote intolerably brute conditions that are putatively presupposed by reason. A science of intelligibility must eliminate bruteness to be systematic, as Fichte says, or presuppositionless, as Hegel says. Moreover, eliminating bruteness requires dialectical logic, which Fichte invents and Hegel develops, to deduce conditions of intelligibility from reason’s self-contradictions. German idealism’s logical revolution provokes Heidegger’s objection that dialectic ineluctably presupposes factical conditions of lived experience, which must be interpreted hermeneutically. The untold history of ‘facticity’ thus contains the deepest parting of the ways after Kant. On the one hand, Hegel follows Fichte in pursuing a presuppositionless science, although Schelling charges Hegel with presupposing both that science’s value and existence itself. On the other hand, Heidegger rejects presuppositionlessness for a hermeneutics of facticity. The trajectory from German idealism to phenomenology is accordingly one in which facticity initially impedes the science of intelligibility yet ultimately characterizes the situation in which this science is possible. Within this trajectory, reason is fated to transform from the hand holding the world to the thrown activity of being-in-the-world.