bluuebunny/crossref_metadata_2025_split huggingface dataset:
Systematic review and meta-analysis of randomized controlled trials evaluating the efficacy of non-surgical periodontal treatment in patients with concurrent systemic conditions
Authors: Joseph Prabhakar , Prabhakar Priya , Holtfreter Birte , Pink Christiane , Suvan Jeanie , Kocher Thomas , Pitchika Vinay 
Published: December 2023

Abstract
Objective
To conduct a systematic review of the published scientific evidence to evaluate the efficacy of nonsurgical periodontal therapy (NSPT) in treating periodontitis in patients with concurrent systemic conditions (diabetes, CVD, erectile dysfunction, chronic kidney disease, rheumatoid arthritis, polycystic ovarian syndrome, obesity, pregnancy). We hypothesised that NSPT results in better periodontal outcomes when compared to untreated controls after follow-up.

Materials and methods
A systematic search (PUBMED/EMBASE) was conducted from 1995 to 2023 to identify randomised controlled trials (RCTs) with a minimum follow-up of 3 months. The primary outcome was the difference in mean probing depth (PD), and the secondary outcomes were mean clinical attachment loss (CAL), percentage of sites with PD ≤ 3 mm (%PD ≤ 3 mm) and percentage of sites with bleeding on probing (%BOP) between the treated and untreated control group in patients with comorbidities.

Results
The electronic search resulted in 2,403 hits. After removing duplicates, 1,565 titles and abstracts were screened according to the eligibility criteria, resulting in 126 articles for full-text screening. Following this, 44 studies were analysed. Restricting to studies with low bias or some concerns, NSPT group demonstrated a 0.55 mm lower mean PD (95%CI: −0.69; −0.41) after 3 months compared to the control group.

Conclusion
Compared to the untreated controls, NSPT notably reduced mean PD, mean CAL, and %BOP while increasing %PD ≤ 3 mm in patients with concurrent systemic conditions. These findings suggest that NSPT is also an effective procedure in managing periodontitis in patients with concurrent systemic conditions.

Trial registration
This systematic review was registered under the protocol registration number CRD42021241517/PROSPERO.
Effects of pain associated with orthodontic tooth movement on tactile sensation of periodontal ligaments
Authors: Shimada Eriya , Kanetaka Hiroyasu , Hihara Hiroki , Kanno Akitake , Kawashima Ryuta , Nakasato Nobukazu , Igarashi Kaoru 
Published: December 2023

Abstract
Objectives
Pain associated with orthodontic tooth movement reportedly reduces periodontal ligament tactile sensation. However, the mechanism associated with the central nervous system remains unclear. This study was conducted by measuring somatosensory evoked magnetic fields (SEFs) during mechanical stimulation of teeth as they were being moved by separator elastics. Findings clarified the effects of pain on periodontal ligament tactile sensation during orthodontic tooth movement.

Materials and Methods
Using magnetoencephalography, SEFs were measured during the application of mechanical stimuli to the mandibular right first molars of 23 right-handed healthy participants (0 h). Separator elastics were subsequently inserted into the mesial and distal interdental portions of the mandibular right first molars. The same mechanical stimuli were applied again 24 h later while the SEFs were measured (24 h). After each SEF measurements, pain was also evaluated using the Visual Analog Scale (VAS).

Results
The VAS values were significantly higher at 24 h than at 0 h (p < 0.05). No significant difference in the peak latencies was found between those obtained at 0 h and 24 h, but the intensities around 40.0 ms in the contralateral hemisphere were significantly lower at 24 h than at 0 h (p < 0.01).

Conclusions
Pain associated with orthodontic tooth movement might suppress periodontal ligament tactile sensation in the primary somatosensory cortex.

Clinical Relevance
Pain associated with orthodontic tooth movement might affect periodontal ligament sensation, consequently causing discomfort during occlusion.
The supporting role of dogs in the inpatient setting: a systematic review of the therapeutic effects of animal-assisted therapy with dogs for children and adolescents in an inpatient setting
Authors: Fornefeld Dustin , Zellin Undine , Schmidt Peter , Fricke Oliver 
Published: December 2023

Abstract
Animal-assisted therapy (AAT) is becoming increasingly popular. The possibilities and guidelines for interventions and methods are very diverse. Currently, published studies mainly concentrate on effects in paediatrics, outpatient therapy and schools. Specific recommendations for AAT in the context of inpatient child and adolescent psychiatry do not exist. This systematic review will attempt to evaluate the existing studies in terms of their methodological quality and specify positive and negative effects, aiming to provide a decision-making aid for everyday clinical practice. A systematic literature search (PubMed/MEDLINE, APA PsycINFO, PubPsych, ProQuest, Google Scholar, and Cochrane Library) according to the PRISMA criteria resulted in 1,908 identified hits, of which 49 articles were reviewed in full text. Three raters contributed to the review of the articles using a criteria-guided codebook. This systematic review is listed in the PROSPERO database (CRD42022358909). Quality analysis was conducted using Effective Public Health Practice Project (EPHPP). Five studies were identified. The majority of these showed deficits in quality. Therapeutic effects and positive influences on the psychopathological status, interpersonal relationships and subjective well-being or attitudes towards canine-assisted therapy (CAT) could be identified. Current studies indicate positive therapeutic effects of CAT in the inpatient treatment of children and adolescents. A cautiously positive perspective is warranted, but a general recommendation for CAT cannot be given. CAT should be carefully considered, planned, and implemented by professionals. For the future, further randomised controlled studies including follow-up studies, larger subject groups and clinically evaluated interventions are necessary to validate the current results.
Family structure, socioeconomic status, and mental health in childhood
Authors: Grüning Parache Laura , Vogel Mandy , Meigen Christof , Kiess Wieland , Poulain Tanja 
Published: December 2023

AbstractThe changing landscape of family structures over the last decades has led to a growing need to investigate its impact on children's well-being. This study examined differences in mental health among children from different family compositions and how these differences may be affected by familial socioeconomic status (SES). Data were collected within the LIFE Child study. Participants included 2828 children aged 3–17 years raised in traditional families, stepfamilies, or single-parent families. Mental health was measured using the Strengths and Difficulties Questionnaire (SDQ (behavioral strengths and difficulties)) and the KIDSCREEN-27 questionnaire (quality of life). Linear regression analyses were applied to examine associations between family structure, SES, and mental health outcomes. Children from single-parent families exhibited worse mental health outcomes than those from traditional families across all domains of the SDQ and the KIDSCREEN-27. Children from stepfamilies showed significantly higher Total Difficulties scores (B = 1.29 and 1.42), with 3- to 10-year-olds displaying higher scores in the Hyperactivity & Inattention (B = 0.61) and Peer Relationship Problems (B = 0.36) subscales, and 11- to 17-year-olds showing higher Conduct Problems (B = 0.31), Emotional Symptoms (B = 0.58), and a worse Parent Relationship scores (B = − 1.82) than children from traditional families (all p < 0.05). After controlling for SES, several associations between family structure and mental health lost significance, while others persisted, particularly among older children. To promote mental health in non-traditional families, interventions should address socioeconomic disparities while also investigating factors contributing to the direct impact of family structure on mental well-being.Trial registration The LIFE Child study is registered on clinicaltrials.gov (No. NCT02550236).
The self-perceived needs of adolescents with suicidal behaviour: a scoping review
Authors: Looijmans Milou , van Bergen Diana , Popma Arne , van Eijk Nikki , Mérelle Saskia , van Veen Sisco , Hawton Keith , Gilissen Renske 
Published: December 2023

Abstract
Suicidal behaviour in adolescents is a major public health problem. Much research on this issue has focused on epidemiology and risk factors for suicidal behaviour, paying less attention to the self-perceived needs of adolescents. However, to increase engagement in suicide prevention, it is important to include the views of adolescents. A scoping review was performed to identify the available empirical study findings, of any study design, related to the self-perceived needs of adolescents with suicidal behaviour. The literature databases Medline, Embase, Psycinfo, CINAHL, ERIC, Scopus, and Web of Science were searched. Twenty-nine studies from 14 predominantly Anglo countries were included in the scoping review. The review showed that girls were overrepresented and that studies predominantly used qualitative approaches. The identified needs of adolescents with suicidal behaviour can broadly be grouped into needs related to the following areas: the importance of connecting with other people; adolescents’ self-help strategies and personal growth after self-harm; mental healthcare; school or study programs; and needs related to society in relation to taboo on suicidal behaviour. Prevention of suicidal behaviour in adolescents will need to focus on development and strengthening of interventions fitting the needs of adolescents in these areas.
The exact worst-case convergence rate of the alternating direction method of multipliers
Authors: Zamani Moslem , Abbaszadehpeivasti Hadi , de Klerk Etienne 
Published: December 2023

AbstractRecently, semidefinite programming performance estimation has been employed as a strong tool for the worst-case performance analysis of first order methods. In this paper, we derive new non-ergodic convergence rates for the alternating direction method of multipliers (ADMM) by using performance estimation. We give some examples which show the exactness of the given bounds. We also study the linear and R-linear convergence of ADMM in terms of dual objective. We establish that ADMM enjoys a global linear convergence rate if and only if the dual objective satisfies the Polyak–Łojasiewicz (PŁ) inequality in the presence of strong convexity. In addition, we give an explicit formula for the linear convergence rate factor. Moreover, we study the R-linear convergence of ADMM under two scenarios.
A unified framework for backpropagation-free soft and hard gated graph neural networks
Authors: Pasa Luca , Navarin Nicolò , Erb Wolfgang , Sperduti Alessandro 
Published: December 2023

AbstractWe propose a framework for the definition of neural models for graphs that do not rely on backpropagation for training, thus making learning more biologically plausible and amenable to parallel implementation. Our proposed framework is inspired by Gated Linear Networks and allows the adoption of multiple graph convolutions. Specifically, each neuron is defined as a set of graph convolution filters (weight vectors) and a gating mechanism that, given a node and its topological context, generates the weight vector to use for processing the node’s attributes. Two different graph processing schemes are studied, i.e., a message-passing aggregation scheme where the gating mechanism is embedded directly into the graph convolution, and a multi-resolution one where neighboring nodes at different topological distances are jointly processed by a single graph convolution layer. We also compare the effectiveness of different alternatives for defining the context function of a node, i.e., based on hyperplanes or on prototypes, and using a soft or hard-gating mechanism. We propose a unified theoretical framework allowing us to theoretically characterize the proposed models’ expressiveness. We experimentally evaluate our backpropagation-free graph convolutional neural models on commonly adopted node classification datasets and show competitive performances compared to the backpropagation-based counterparts.
Predator recognition learning by northern redbelly dace Chrosomus eos from a small kettle lake with a dynamic predator community
Authors: Soukup Jack C. , Wisenden Brian D. 
Published: December 2023

AbstractPredation, and the risk of predation, shape the ecology, behavior, and evolution of many species. Small fishes navigate a perilous landscape of risk in the shallow waters of the littoral zone. Moreover, in small lakes, the predator community can be dynamic due to stochastic colonization and extirpation events. These conditions select for the ability by small fish to acquire recognition of novel predators through associative learning. Chemical cues associated with predation events, such as damage-released chemical cues from conspecifics, and the odor of predators, inform prey of the presence of risk, and facilitate acquired recognition of novel predator odor. Deming Lake, MN, is a small meromictic lake with intermittent connections to neighboring lakes in the watershed. Annual sampling of the littoral fish community between the years 2000 and 2023 reveals a history of colonization and extirpation by relatively large-bodied species such as yellow perch Perca flavescens and pumpkinseed sunfish Lepomis gibbosus. Ice cover data, combined with limnological depth profiles of dissolved oxygen, confirm that dissolved oxygen is limiting during the winter and consistent with the hypothesis that extirpation of large-bodied species in Deming Lake is likely due to winter anoxia. These data set the stage for an experimental demonstration of acquired recognition of the odor of allopatric rock bass Ambloplites rupestris by bass-naïve northern redbelly dace Chrosomus eos from Deming Lake. Rock bass have been absent from Deming Lake since at least the year 2000. Predator-recognition learning allows redbelly dace, and many other small-bodied fishes that face variable predator species over ontogenetic, spatial, and temporal scales, a mechanism to adapt quickly to indicators of predation risk.
Cultivation of barley seedlings in a coffee silverskin-enriched soil: effects in plants and in soil
Authors: Salbitani Giovanna , Chianese Maria Rosaria , Bossa Rosanna , Bencivenga Tammaro , Carraturo Federica , Nappo Antonio , Guida Marco , Loreto Francesco , Carfagna Simona 
Published: December 2023

Abstract
Aims
Coffee silverskin (CS) is the most abundant waste from coffee roasting. In this research, the potential of CS as soil fertilizer for barley (Hordeum vulgare L.) cultivation was evaluated.

Methods
Barley plants were grown, for 10 days from the start of germination, in soils mixed with different CS percentages (0, 2, 6 or 10%). The effects of CS addition on soil capacity to retain water and on the mold/yeast community were evaluated. Physio-morphological and biochemical responses of leaves and roots of barley plants growing in CS-enriched soil were evaluated.

Results
Root and shoot length decreased in plants grown with CS, but biomass was less affected and even increased at 2% CS. Photosynthesis was higher in barley seedlings grown on CS-enriched soil than in control plants. However, Chl b was reduced in leaves of plants grown with CS. The total leaf protein content did not change with moderate CS additions in soil. However, when grown in soil with 10% CS, a significant reduction of total protein and Rubisco was observed. Extracts of barley shoots from plants grown in soil with 10% CS showed a greater antioxidant capacity with respect to all other experimental conditions.

Conclusions
We conclude that CS addition to soil may improve soil property to retain water and, at low concentrations (2% w/w) positively affects barley physiology and growth.
Occurrence and risk assessment of okadaic acid, dinophysistoxin-1, dinophysistoxin-2, and dinophysistoxin-3 in seafood from South Korea
Authors: Park Jong Bin , Cho Solyi , Lee Sang Yoo , Park Su Mi , Chun Hyang Sook 
Published: December 2023

AbstractThe okadaic acid (OA)-group toxins, including OA, dinophysistoxin-1 (DTX1), dinophysistoxin-2 (DTX2), and dinophysistoxin-3 (DTX3), cause diarrheic shellfish poisoning in humans. To manage OA-group toxins more strictly, Korean regulations were recently revised to consider OA, DTX1, DTX2, and DTX3 combined. Thus, our study characterized the occurrence of OA, DTX1, DTX2, and DTX3 in seafood distributed across South Korea, and a risk assessment of seafood consumption was conducted. Two hundred and seventeen samples from 16 bivalve and 7 non-bivalve species collected from three representative coastal areas in 2021 were analyzed via liquid chromatography-tandem mass spectrometry. OA, DTX1, and DTX3 were detected in 2.3%, 4.1%, and 9.2% of the examined samples, with positive mean levels of 11.3, 16.4, and 40.9 µg/kg, respectively. DTX2 was not detected in any of the samples. At least one OA-group toxin was detected in the bivalve samples, including blood clams, pan shells, hard clams, mussels, and scallops, whereas none were detected in non-bivalves. The estimated acute exposure to OA-group toxins through the intake of seafood in the Korean population and consumer groups was low, ranging from 24.7 to 74.5% of the recommended acute reference dose (ARfD) of 0.33 μg OA equivalents/kg body weight. However, for the scallop consumers aged 7–12 years, acute exposure to OA-group toxins exceeded the ARfD, indicating a possible health risk. These results suggest that including DTX3 in the new regulatory limits is appropriate to protect Korean seafood consumers from exposure to OA-group toxins.
A Proof of Concept Study to Assess the Imbalance of Self-Reported Wanting and Liking as a Predictor of Problematic Addictive Behaviors
Authors: File Domonkos , Bőthe Beáta , File Bálint , Griffiths Mark D. , Demetrovics Zsolt 
Published: December 2023

AbstractTolerance, one of the key features of addiction, is a highly debated criterion for behaviors, considered controversial and difficult to assess. The Incentive-Sensitization Theory of Addiction (IST) provides a robust empirical background on the dynamics of the motivational and hedonic systems underlying addiction, reflecting tolerance. The aim of this proof-of-concept study was to introduce wanting and liking as an IST-based measure of tolerance. Survey data were analyzed on two potentially problematic substance use behaviors (alcohol and nicotine use) and seven potentially problematic behaviors (eating, gaming, pornography use, social media use, internet use, television series watching, and working) of 774 participants (517 women, Mage = 35.8 years, SD = 11.84), using linear regression models. The models describing the relationship between usage frequency and the difference between self-reported wanting and liking were significant for all of the investigated substance use and potential behavioral addictions. As a general pattern, the balance of wanting and liking was disrupted with increasing usage/behavior frequency, with a steady increment in wanting in all investigated cases. The findings indicate that the proposed approach holds promise as an empirically robust tool for addiction research, offering the potential to compare substance and behavioral addictions on a unified dimension.
Antibiotic Residues and Zinc Concentrations in the Livers and Kidneys of Portuguese Piglets—Relationship to Antibiotic and Zinc Resistance in Intestinal Escherichia coli
Authors: Cardoso Olga , Assis Gabriela , Donato Maria M. , Henriques Sara Carolina , Freitas Andreia , Ramos Fernando 
Published: December 2023

AbstractMetal ions such as zinc and copper have been used as alternatives to antibiotics, to improve animal health and growth rates in pig farming. This study aims to determine antibiotic residues and Zn concentration in piglets’ livers (n = 56) and kidneys (n = 60); and to examine the correlation between the use of Zn and antibiotics, and resistance to Zn and antibiotics of Escherichia coli isolated from piglets’ faeces (n = 60). Samples were collected from randomly selected healthy piglets (n = 60); antibiotic residues were quantified by ultra-high-performance-liquid-chromatography time-of-flight mass spectrometry (UHPLC-ToF–MS); Zn was quantified using flame atomic absorption spectrometry (FAAS); microbiological methods were used for E. coli isolation, antibiotic susceptibility, and Zn minimal inhibitory concentration; and Real-Time PCR was used for gene detection. The presence of antibiotic residues and Zn concentrations in the liver was found to be negatively correlated, whilst no significant difference was observed in the kidney. In E. coli isolated from piglet faeces considered to be susceptible or multi-drug-resistant, no significant difference was found between Zn concentrations in the liver and in the kidney, which appears to indicate that Zn accumulated in the liver and in the kidney does not promote resistance to antibiotics in E. coli. The isolates showed tolerance to Zn which would suggest that antibiotic resistance and phenotypic tolerance to Zn in these isolates are not related. The genes zitB and zntA associated to Zn tolerance, were predominantly found in the more resistant Zn isolates. The findings provide insights on how Zn use in pig production maintains antibiotic resistance and metal tolerance in bacteria, with implications for One Health.
Wnt7a Decreases Brain Endothelial Barrier Function Via β-Catenin Activation
Authors: Manukjan Narek , Chau Steven , Caiment Florian , van Herwijnen Marcel , Smeets Hubert J. , Fulton Daniel , Ahmed Zubair , Blankesteijn W. Matthijs , Foulquier Sébastien 
Published: December 2023

AbstractThe blood-brain barrier consists of tightly connected endothelial cells protecting the brain’s microenvironment from the periphery. These endothelial cells are characterized by specific tight junction proteins such as Claudin-5 and Occludin, forming the endothelial barrier. Disrupting these cells might lead to blood-brain barrier dysfunction. The Wnt/β-catenin signaling pathway can regulate the expression of these tight junction proteins and subsequent barrier permeability. The aim of this study was to investigate the in vitro effects of Wnt7a mediated β-catenin signaling on endothelial barrier integrity. Mouse brain endothelial cells, bEnd.3, were treated with recombinant Wnt7a protein or XAV939, a selective inhibitor of Wnt/β-catenin mediated transcription to modulate the Wnt signaling pathway. The involvement of Wnt/HIF1α signaling was investigated by inhibiting Hif1α signaling with Hif1α siRNA. Wnt7a stimulation led to activation and nuclear translocation of β-catenin, which was inhibited by XAV939. Wnt7a stimulation decreased Claudin-5 expression mediated by β-catenin and decreased endothelial barrier formation. Wnt7a increased Hif1α and Vegfa expression mediated by β-catenin. However, Hif1α signaling pathway did not regulate tight junction proteins Claudin-5 and Occludin. Our data suggest that Wnt7a stimulation leads to a decrease in tight junction proteins mediated by the nuclear translocation of β-catenin, which hampers proper endothelial barrier formation. This process might be crucial in initiating endothelial cell proliferation and angiogenesis. Although HIF1α did not modulate the expression of tight junction proteins, it might play a role in brain angiogenesis and underlie pathogenic mechanisms in Wnt/HIF1α signaling in diseases such as cerebral small vessel disease.