bluuebunny/crossref_metadata_2025_split huggingface dataset:
The influence of gender inequality on women’s cancer mortality in European countries: a quantitative study
Authors: Koengkan Matheus , Fuinhas José Alberto 
Published: December 2023

Abstract
Aim
This study investigates the impact of gender inequality on cancer mortality among European women across 27 countries from 2013 to 2020.

Subject and methods
The study explores the link between gender inequality and cancer mortality, employing pooled ordinary least squares regression. It evaluates socioeconomic gaps, healthcare access disparities, risky behaviours, and elements like screening, education, and life expectancy. The study also investigates how healthcare spending, employment, self-perceived health, and leisure activities influence mortality.

Results
The study shows that breast and cervical cancer screenings (BCS) significantly reduce cancer-related deaths among European women (CDW), with a negative impact of −0.0875. Similarly, tertiary education and participation in education and training (WEP) show a negative impact of −0.0021. Absolute life expectancy for women at birth (LEW) demonstrates a negative impact of −5.2603, all contributing to decreased cancer-related deaths.
Conversely, certain variables have a contradictory positive impact on CDW. Total healthcare expenditure (HCE) has a positive impact of +0.0311, and full-time equivalent employment (FER) of +0.3212. Women engaging in activities (WLW) has a positive impact of +0.6572. Self-perception of good health (WHG), refraining from smoking or harmful drinking (NSN) (+0.2649), and an active lifestyle with consumption of fruits and vegetables (PAF) (+0.2649) also impact positively, collectively contributing to increased cancer mortality among women.

Conclusion
The study highlights the importance of combating gender inequality to decrease cancer deaths in European women. Strategies include closing healthcare gaps and enhancing health education. Complex links between smoking, alcohol, and cancer mortality require further research. Interventions targeting disparities, healthcare access, and risky behaviours can notably lower cancer mortality.
Conflict-free electric vehicle routing problem: an improved compositional algorithm
Authors: Roselli Sabino Francesco , Fabian Martin , Åkesson Knut 
Published: December 2023

AbstractThe Conflict-Free Electric Vehicle Routing Problem (CF-EVRP) is a combinatorial optimization problem of designing routes for vehicles to execute tasks such that a cost function, typically the number of vehicles or the total travelled distance, is minimized. The CF-EVRP involves constraints such as time windows on the tasks’ execution, limited operating range of the vehicles, and limited capacity on the number of vehicles that a road segment can simultaneously accommodate. In previous work, the compositional algorithm ComSat was introduced to solve the CF-EVRP by breaking it down into sub-problems and iteratively solve them to build an overall solution. Though ComSat showed good performance in general, some problem instances took significant time to solve due to the high number of iterations required to find solutions for two sub-problems, namely the Routing Problem, and the Paths Changing Problem. This paper addresses the bottlenecks of ComSat and presents new formulations for both sub-problems in order to reduce the number of iterations required to find feasible solutions to the CF-EVRP. Experiments on sets of benchmark instances show the effectiveness of the presented improvements.
Corruption as a push and pull factor of migration flows: evidence from European countries
Authors: Bernini Andrea , Bossavie Laurent , Garrote-Sánchez Daniel , Makovec Mattia 
Published: December 2023

AbstractConclusive evidence on the relationship between corruption and migration has remained scant in the literature to date. Using 2008–2018 data on bilateral migration flows across EU28 and EFTA countries and four measures of corruption, we show that corruption acts as both push and pull factors on migration patterns. Based on a gravity model, a 1-unit increase in the corruption level in the origin country is associated with an 11% increase in out-migration. The same 1-unit increase in corruption in the destination country is associated with a 10% decline in in-migration.
Parental Monitoring of Early Adolescent Social Technology Use in the US: A Mixed-Method Study
Authors: Hernandez J. Maya , Ben-Joseph Elana Pearl , Reich Stephanie , Charmaraman Linda 
Published: December 2023

AbstractParental monitoring of digital media use evolves throughout childhood and adolescence and become increasingly important when autonomy seeking on social technologies emerges during early adolescence. We investigate a survey cohort of 248 US parents of early adolescents and their parental media monitoring behaviors (i.e., restrictive, active, deference), the family context (i.e., closeness and parent technoference), and perceptions of child’s problematic internet use. Using an explanatory mixed methods approach, the results of this study reveal that restrictive parental monitoring of adolescents’ digital media use is positively associated with child’s problematic internet use. However, active and deference monitoring are not associated with early adolescent problematic internet use and positively associated with family contexts. Familial closeness and technoference are consistent negative and positive correlates, respectively, of perceived problematic use among early adolescents. Qualitative interviews with a subset of 31 parents reveal while most parents report restrictive behaviors, multiple techniques (e.g., active, surveillant, and deference) are also leveraged when navigating their child’s online behaviors. Parents tended to converge on the same types and reasons for restrictive monitoring of media, whereas for other approaches the reasons behind their decision-making were quite divergent. The implication of this study is that parental media monitoring behaviors during early adolescence are rapidly evolving and not confined to a singular strategy, often related to prevention of or intervention on their child’s online behavior patterns. Understanding the family dynamics and parent involvement of adolescent’s digital media use remains critical in prevention of child’s problematic behaviors and promotion of positive online behaviors.
Progesterone improved the behavior of PC12 cells under OGD/R by reducing FABP5 expression and inhibiting TLR4/NF-κB signaling pathway
Authors: Li Chunlin , Li Bowen , Qu Linglong , Song Ruichang , Liu Hui , Su Shanshan 
Published: December 2023

AbstractHerein, PC12 cells were applied to detect the impact of progesterone under oxygen glucose deprivation/reperfusion (OGD/R) stimulation. The cell proliferation of PC12 cells was evaluated by cell counting kit-8 assay, and the concentrations of MDA, ROS and SOD were examined by their corresponding Enzyme Linked Immunosorbent Assay kits. The invasion and migration properties of PC12 cells were evaluated by transwell and wound healing assays, respectively. The expression patterns of related genes were evaluated by western blot and qPCR. Under OGD/R stimulation, progesterone treatment could elevate the viability of PC12 cells, reduce the levels of MDA and ROS, and elevate the concentration of SOD. Moreover, progesterone treatment could strengthen the invasion and migration abilities of PC12 cells under OGD/R condition, as well as decrease the apoptosis and inflammation. FABP5 expression was significantly increased in PC12 cells under OGD/R stimulation, which was reversed after progesterone stimulation. Under OGD/R stimulation, the protective effects of progesterone on PC12 cells were strengthened after si-FABP5 treatment. The protein levels of TLR4, p-P65 NF-κB, and P65 NF-κB in OGD/R-induced PC12 cells were increased, which were inhibited after progesterone treatment. Progesterone exerted protective effects on PC12 cells by targeting FABP5 under OGD/R stimulation.
DNA Aptamer-Based Staining and Fluorescence Microscopy for Rapid Detection of Cyclospora Cayetanensis Oocysts
Authors: Bruno John G. , Sivils Jeffrey , Natarajan Mohan , Mohan Sumathy 
Published: December 2023

Abstract
There are no commercial antibodies for detection of Cyclospora cayetanensis, only a relatively slow polymerase chain reaction (PCR) test developed by the U.S. Food and Drug Administration (FDA). However, DNA aptamers have recently been developed by our group against known proteins and whole oocysts of C. cayetanensis and shown to specifically detect the oocysts when attached on their 5’ ends to red-emitting fluorophores and used as probes for fluorescence microscopy. Aptamers developed against recombinant wall protein 2 and TA4 antigen-like protein as well as whole oocysts specifically stained C. cayetanensis oocysts while exhibiting little, if any, staining of numerous other waterborne parasite species. Interestingly, the aptamers stained both exterior cell wall moieties and internal structures, suggesting that the aptamers penetrate the oocysts even without added detergents.
The complete mitochondrial genome of Octopus vulgaris
Authors: Fee Gareth N. , Roura Alvaro , Emami-Khoyi Arsalan , Teske Peter R. 
Published: December 2023

Abstract

Background
The Octopus vulgaris species complex consists of numerous morphologically similar but genetically distinct species. The current publicly available mitogenome of this species has been generated from a specimen collected from Tsukiji Fish Market, Tokyo, Japan. Octopus from the northwestern Pacific Ocean are now considered to be a separate species, Octopus sinensis. For this reason, we hypothesised that the current record of O. vulgaris was sequenced from a specimen of O. sinensis. Here, we sequenced the first complete mitogenome of a specimen of Octopus vulgaris sensu stricto that was collected from the species’ confirmed distribution areas in northeastern Atlantic.

Methods and results
The complete mitogenome was assembled de novo and annotated using 250 bp paired-end sequences. A single circular contig 15,655 bp in length with a mean read coverage of 1089 reads was reconstructed. The annotation pipeline identified 13 protein-coding genes (PCGs), 22 transfer RNAs (tRNA) and two ribosomal RNAs. A maximum likelihood phylogenetic tree recovered the assembled mitogenome as the sister taxon of a monophyletic group comprising O. sinensis and the previously published mitogenome of “O. vulgaris” from Japan. This confirms that the latter was a Japanese specimen of O. sinensis.

Conclusion
The mitogenome sequenced here is the first to be published for Octopus vulgaris sensu stricto. It represents an important first step in genetics-informed research on the evolution, conservation, and management of this commercially important species.
The prosody of Spanish acronyms
Authors: Torres-Tamarit Francesc , Martínez-Paricio Violeta 
Published: December 2023

AbstractThis paper presents a first attempt to formally characterize the prosodic properties of Spanish acronyms. Based on the examination of a dataset and the results of a written questionnaire and perception test administered to native speakers, the stress patterns and prosodic size of Spanish acronyms are investigated. We show that stress in acronyms follows the regular stress patterns of the language. We further claim that acronyms are restricted to an upper limit of three syllables, which we explain by resorting to layered feet. Additionally, we show that an interesting minimality requirement applies exclusively to acronyms, one that must be expressed not in terms of syllable weight, but rather in terms of the number of segments.
Finding the structure of parliamentary motions in the Swedish Riksdag 1971–2015
Authors: Bruinsma Bastiaan , Johansson Moa 
Published: December 2023

AbstractThe current increase in the number of large, open sets of unstructured textual data has created both opportunities and challenges for social scientists. Here, we explore if and how we can use such data by looking at a dataset of over 144,000 documents used by parliamentary committees in Sweden. Of these, we aim to understand: (a) the topical content of these motions, (b) how these topics have changed over time, and (c) how these topics differ across political parties. To do so, we use a Structural Topic Model, which allows us to not only find the topics using the textual data itself, but also to include the documents’ metadata, such as authorship and date of publication. Doing so, we find 30 topics, which we combine into 9 broader themes. We find that these themes often rise and fall in popularity in line with historical events, and relate to the various political parties as we would expect. Throughout our analysis, we provide a step-by-step overview of how to use structural topic models in practice and also how to handle the type of dataset we use here.
The genetics of Graves’ disease
Authors: Grixti Lydia , Lane Laura C. , Pearce Simon H 
Published: December 2023

AbstractGraves’ disease (GD) is the commonest cause of hyperthyroidism and has a strong female preponderance. Everyday clinical practice suggests strong aggregation within families and twin studies demonstrate that genetic factors account for 60-80% of risk of developing GD. In this review, we collate numerous genetic studies and outline the discoveries over the years, starting with historic candidate gene studies and then exploring more recent genome-wide linkage and association studies, which have involved substantial cohorts of East Asian patients as well as those of European descent. Variants in genes including HLA, CTLA4, and PTPN22 have been shown to have substantial individual effects on disease susceptibility. In addition, we examine emerging evidence concerning the possibility that genetic variants may correlate with relevant clinical phenotypes including age of onset of GD, severity of thyrotoxicosis, goitre size and relapse of hyperthyroidism following antithyroid drug therapy, as well as thyroid eye disease. This review supports the inheritance of GD as a complex genetic trait, with a growing number of more than 80 susceptibility loci identified so far. Future implementation of more targeted clinical therapies requires larger studies investigating the influence of these genetic variants on the various phenotypes and different outcomes of conventional treatments.
Musical works are mind-independent artifacts
Authors: Mikalonytė Elzė Sigutė 
Published: December 2023

AbstractRealism about musical works is often tied to some type of Platonism. Nominalism, which posits that musical works exist and that they are concrete objects, goes with ontological realism much less often than Platonism: there is a long tradition which holds human-created objects (artifacts) to be mind-dependent. Musical Platonism leads to the well-known paradox of the impossibility of creating abstract objects, and so it has been suggested that only some form of nominalism becoming dominant in the ontology of art could cause a great change in the field and open up new possibilities. This paper aims to develop a new metaontological view starting from the widely accepted claim that musical works are created. It contends that musical works must be concrete and created objects of some sort, but, nevertheless, they are mind-independent, and we should take the revisionary methodological stance. Although musical works are artifacts, what people think about them does not determine what musical works are. Musical works are similar to natural objects in the following sense: semantic externalism applies to the term ‘musical work’ because, firstly, they possess a shared nature, and, secondly, we can be mistaken about what they are.
Verwaltungsverflechtungen im föderalen System
Authors: Bogumil Jörg , Gräfe Philipp 
Published: December 2023

ZusammenfassungIn den letzten Jahren sind Probleme im Verwaltungsvollzug stärker thematisiert worden, insbesondere am Beispiel von Krisen. Viele dieser Problemlagen im Kontext der Migrations- und Integrationspolitik, im Bereich der Gesundheitspolitik (Corona), in der Sozialpolitik oder der nur sehr zögerlich vorankommenden Digitalisierung öffentlicher Dienstleistungen in Deutschland lassen sich dabei auf Probleme in der Verflechtung von Verwaltungen zurückführen. Der Beitrag entwickelt dazu unter Rückgriff auf das Konzept der „Verwaltungsverflechtung“ ein empirisches Analysekonzept für Vollzugshandeln, das sowohl die Verflechtungsstruktur als auch die Schnittstellenbearbeitung als analytische Dimensionen in den Blick nimmt. Es wird argumentiert, dass die Analyse dieser Dimensionen ermöglicht, jene strukturellen Probleme systematisch offenzulegen und zu erklären, die im Vollzugshandeln in unterschiedlichen Verwaltungsbereichen regelmäßig Koordinationsdefizite bedingen.
Banded Versus Non-banded Sleeve Gastrectomy: 5-Year Results of a 3-Year Randomized Controlled Trial
Authors: Fink Jodok M. , Reutebuch Marina , Seifert Gabriel , Laessle Claudia , Fichtner-Feigl Stefan , Marjanovic Goran , Fink Mira 
Published: December 2023

Abstract
Purpose
Banded sleeve gastrectomy (BSG) has been shown to enable better weight loss than non-banded sleeve gastrectomy (SG) in retrospective analyses. These findings were supported by two randomized controlled trials (RCT). However, to date, mid-term prospective data is not available.

Materials and Methods
We invited all 94 patients of an RCT comparing banded to non-banded sleeve gastrectomy at 3 years (DRKS00007729) for a 5-year follow-up visit. Eighty-two patients (BSG n = 42; SG n = 40) came for evaluation. Outcome measures were identical with the RCT to allow longitudinal comparison. Data analysis was descriptive and focused on biometric data, development of comorbidities, mid-term complications, quality of life, and type of body contouring surgery (BCS).

Results
The per-protocol analysis revealed a treatment difference of 9% (CI − 1.5 to 19.6) excess weight loss (EWL). Total weight loss (TWL) was 27.4% (CI 23.5–31.3) after SG and 31.6% (CI 27.3–35.5) after BSG. Twenty percent of patients after SG and 11.9% following BSG had been converted to a gastric bypass. Type 2 diabetes went into remission in most patients (SG 66.7% vs. BSG 63.6%). Antihypertensive medication was stopped or reduced in 81.3% after SG and 80% after BSG. Reflux symptoms were similar in both groups (symptoms $$\ge$$
≥
1/ week: SG 28.2% vs. BSG 26.8%). Frequency of postprandial regurgitation was higher after BSG (SG 23% vs. BSG 59%). Forty percent of patients had undergone BCS at time of follow-up.

Conclusion
Five-year weight loss after BSG was 9% EWL and 4.2% TWL higher compared to SG. The main added morbidity following BSG was postprandial regurgitation.

Graphical abstract
Forensisch-psychiatrische Implikationen bei Post‑/Long-COVID
Authors: Dreßing Harald , Dreßing Andrea 
Published: December 2023

ZusammenfassungAls Folge einer COVID-19-Infektion kann eine Long‑/Post-COVID-Symptomatik auftreten, deren Symptomatik äußerst vielfältig sein kann. Für die forensisch-psychiatrische Begutachtung auf zivil- und sozialrechtlichem Gebiet stellt dabei die Einschätzung einer chronischen Fatigue-Symptomatik eine häufige Fragestellung dar. Vor der COVID-19-Pandemie ergaben sich ähnliche gutachtliche Herausforderungen bei der Thematik der myalgischen Enzephalomyelitis. Gutachten zu dieser Thematik waren schon vor der COVID-19-Pandemie häufig umstritten, es handelte sich aber eher um Einzelfälle. Die pandemiebedingte Zunahme solcher Fragestellungen führt dazu, dass sich viele gutachtlich tätigen KollegInnen nun verstärkt damit auseinandersetzen müssen. Die vorliegende Arbeit stellt die für die gutachtliche Praxis relevanten Leitlinien und die in Deutschland zu berücksichtigenden rechtlichen Rahmenbedingungen zu dem Thema vor, sowie einige empirischen Studien zu ätiopathogenetischen Mechanismen und macht Vorschläge, wie diese in den gutachtlichen Kontext kritisch einbezogen werden können.
Celastrol suppresses human pancreatic cancer via m6A-YTHDF3-mediated downregulation of Claspin and Bcl-2
Authors: Zhou Yang , Zhuang Haoran , Liu Yuxiang , Yin Jing , Wei Xiaoying , Qiu Yue , Tian Zhen , Miao Tingyu , Chen Jing , Li Peifen , Xu Xiao , Wu Wenjuan , Li Huanan , Shen Weigan 
Published: December 2023

Abstract
Background
Celastrol has been revealed to exhibit anticancer pharmacological activity, however, the molecular mechanisms of celastrol involved in pancreatic cancer remain to be further elucidated. The present study was to illustrate whether celastrol suppresses pancreatic cancer through modulating RNA m6A modification.

Methods
Effect of celastrol treatment on the malignant phenotypes of pancreatic cancer cells was evaluated by CCK-8 assay, EdU assay, colony formation assay, flow cytometry analysis and subcutaneous xenograft experiments. RNA sequencing (RNA-seq) analysis was carried out to analyze the genes differentially expressed in celastrol-treated pancreatic cancer cells. RT-qPCR, Western blotting and immunohistochemistry were employed to evaluate the expression of the indicated genes. RNA dot blot and quantification of total RNA m6A modification assays, MeRIP-qPCR assay, RIP-qPCR assay, RNA stability and protein stability assays were applied to evaluate the regulatory mechanism of celastrol treatment in pancreatic cancer cells.

Results
We demonstrated that celastrol suppressed cell proliferation and induced cell cycle arrest and apoptosis of pancreatic cancer cells in vitro, and decreased tumor growth in vivo. Specifically, Bcl-2, Claspin, METTL3 and YTHDF3 were identified as the potential targets of celastrol treatment in pancreatic cancer cells. Moreover, our results indicated that celastrol treatment downregulated METTL3 and decreased m6A levels of Claspin and Bcl-2 mRNA, leading to the degradation of Claspin and Bcl-2 mRNA in pancreatic cancer cells. Furthermore, we revealed that celastrol treatment downregulated Claspin and Bcl-2, at least in part, in an m6A-YTHDF3-mediated manner in pancreatic cancer cells.

Conclusion
Our study highlighted a novel mechanism underlying celastrol-induced cellular proliferation inhibition and apoptosis in pancreatic cancer cells via m6A-YTHDF3-mediated downregulation of Claspin and Bcl-2.
Moisture-Electric–Moisture-Sensitive Heterostructure Triggered Proton Hopping for Quality-Enhancing Moist-Electric Generator
Authors: Yang Ya’nan , Wang Jiaqi , Wang Zhe , Shao Changxiang , Han Yuyang , Wang Ying , Liu Xiaoting , Sun Xiaotong , Wang Liru , Li Yuanyuan , Guo Qiang , Wu Wenpeng , Chen Nan , Qu Liangti 
Published: December 2023

AbstractMoisture-enabled electricity (ME) is a method of converting the potential energy of water in the external environment into electrical energy through the interaction of functional materials with water molecules and can be directly applied to energy harvesting and signal expression. However, ME can be unreliable in numerous applications due to its sluggish response to moisture, thus sacrificing the value of fast energy harvesting and highly accurate information representation. Here, by constructing a moisture-electric–moisture-sensitive (ME-MS) heterostructure, we develop an efficient ME generator with ultra-fast electric response to moisture achieved by triggering Grotthuss protons hopping in the sensitized ZnO, which modulates the heterostructure built-in interfacial potential, enables quick response (0.435 s), an unprecedented ultra-fast response rate of 972.4 mV s−1, and a durable electrical signal output for 8 h without any attenuation. Our research provides an efficient way to generate electricity and important insight for a deeper understanding of the mechanisms of moisture-generated carrier migration in ME generator, which has a more comprehensive working scene and can serve as a typical model for human health monitoring and smart medical electronics design.