bluuebunny/crossref_metadata_2025_split huggingface dataset:
Development of Flipbook with Living Value Education Program-Based as Teaching Materials to Improve Students' Religious Values
Authors: Nada Damai Ikhsa , Apriani An-Nisa , Sari Indah Perdana , Ariyani Yusinta Dwi 
Published: February 2024

The current use of technology-based learning media is still limited to textbooks from the government and projectors that display presentation slides or videos. The current study used a flipbook as a new alternative for teaching materials with additional religious values. This study aimed to 1) generate a flipbook for social and science studies (Ilmu Pengetahuan Alam dan Sosial or IPAS) with living values education program-based feasible to improve religious values; 2) determine the responses about the IPAS flipbook as a learning material from the teachers; 3) evaluate the responses about the IPAS flipbook as a learning material from the teachers from the students in enhancing their religious characteristics. The research design used was a research-and-development with a 4D research and development model (define, design, development, and dissemination). The subjects of the validation test are material experts and media experts, while the responders to the media are teachers and 19 fourth-grade students of SD IT Samawi. The data was collected using interviews, observations, and questionnaires. The data analysis methods used are qualitative and quantitative. The results showed that the feasibility assessment of the IPAS flipbook is categorized as having "very good" criteria by material experts (average score of 4.6) and media experts (average score of 4.1). Furthermore, according to the fourth-grade teachers from SD IT Samawi, the flipbook media received an average score of 4.8, with "very good" criteria and is worthy of use. The fourth-grade students of SD IT Samawi responded well to the IPAS flipbook media, which obtained positive response results with an average prevalence of 90.7%.
Treatment of osteoarthritis knee with bone marrow aspirate concentrate injection
Authors: Saha Somesh , Das Chinmoy , Das Partha pratim , Gupta Navonil 
Published: February 2024

To assess the clinical effectiveness and safety of bone marrow aspirate concentrate (BMAC) injections given intraarticularly as a potential treatment for knee osteoarthritis (OA). Data from 60 patients with knee osteoarthritis treated with BMAC injection at a single centre between December 2021 and December 2022 were retrospectively examined. We only included patients with idiopathic osteoarthritis. Post-traumatic osteoarthritis, prior knee surgery, ageless then 50 years or over 85 years, an active infection, uncontrolled diabetes mellitus, rheumatological or another systemic condition, cancer, or immunosuppressive medication use were all exclusion factors. A single-spin manual approach was used to aspirate and concentrate bone marrow from the iliac crest. The Numeric pain scale (NPS) and Oxford knee score (OKS) were used to evaluate patients both before and after the treatment. A 12-month follow-up period was used. The statistical analysis comprised a total of 60 patients. With a mean age of 67 years (range 50-85), there were 42 females and 18 males. At the end of the follow-up period, the mean NPS reduced from 8.12 to 4.31 (p&#60; 0.001) and the mean OKS rise from 22.30 to 34.74 (p &#60;0.001). There were no problems. A single BMAC intra-articular injection is a dependable and safe technique that improves the clinical condition of knee OA.
An ethno-botanical survey of medicinal plants used in the treatment of fracture and dislocation in Ogugu, Kogi State Nigeria
Authors: Ali Bashir Alabi , Unoyiza Umar Sabdat , Salisu Suleiman Mohammed , Suleiman Kutama Ahmad , Tijani Kokori Bajeh 
Published: February 2024

The documented information on traditional medicinal plants in Ogugu communities of Kogi State is vague and limited to its species and thus very little research has been done on these medicinal plants. An Ethno-botanical study was conducted to take inventory of the species by the inhabitants of various communities in Ogugu, Olamaboro Local Government area of Kogi State in bone fracture treatment and dislocation. The study was carried out between May through September 2019. Ethnomedicinal knowledge was gathered from 20 traditional bone setters in 10 communities using questionnaires. The plants most referenced from the questionnaire were collected and identified using various standard methods and procedures. 80% of the respondents were male while 20% were female. 40% were in the range of 31-41 years of age and only 10% were in the age range of 20-30 years. About 45% has no formal education while only 5% had a university degree. TBS with most year of experience (21-25 years) are only 5% while the profession is dominated by those of moderate time of practice (11-15 years) with 40% representative. A total of 49 medicinal plant species distributed in 27 families and genera were documented. Family Euphorbiaceae was found to be mostly used for fracture treatment. The most frequent used plant parts were the leaves (49.5%). The method of preparation of the herbal remedies were generally best in the form of poultice administered in the form of paste to give the best result in fracture and bone setting treatment.
Distraction assisted management of post burn contracture of hand
Authors: Chittoria Ravi Kumar , J S Amrutha 
Published: February 2024

Burns are one of the injuries that causes significant morbidity and reduced quality of life.Despite making up only 3% of the body's surface area, hands are involved in more than 80% of serious burs. Scarring, joint contractures and stiffness are devastating in the upper extremity due to its dependence. In this article, we have used Distraction assisted management is one of the methods for the management of finger webspace contracture release. In this case, we will be using a JESS distractor in the management of web space contracture in the upper extremity.
Factors influencing seed cotton marketing decisions by smallholder farmers in Zimbabwe
Authors: Maxmore Njanji , Cosmas Parwada 
Published: February 2024

Economic reforms such as the liberalization of export and processing-linked marketing channels have encouraged farmers to produce more. Unfortunately, cotton production in Zimbabwe has been declining regardless of such interventions. Why is the production declining despite these interventions including the government-free inputs and supported extension services? Cotton marketing is one of the main factors that influence overall quantities of a commodity to be produced but the practices and behavior of farmers are relatively unknown and unpredictable in the cotton markets. Therefore, this study was to explore factors influencing smallholder farmers' cotton marketing decisions in three cotton-producing provinces of Zimbabwe. A representative sample of 1080 cotton farmers were randomly selected from these provinces and a double hurdle model was used to evaluate market participation and intensity guided by probit model and censored tobit model respectively. Results showed that the decision to participate in cotton marketing was exclusively influenced by experience in cotton production while the intensity of cotton marketing was exclusively influenced by household labour and access to information. Market prices did not significantly (P<0.05) influence both the participation and intensity of cotton markets. The source of inputs and affiliation to marketing associations influence both marketing decisions. It is recommended that the government of Zimbabwe should revise the existing cotton marketing policies to encourage many buyers into cotton markets. The establishment of cotton marketing hubs can increase cotton marketing participation and intensity through increased access to decentralised marketing options.
Implementasi Asas Nasional Aktif dalam Tindak Pidana Pencucian Uang: Studi Kasus Perjalanan Panjang Kasus Nazaruddin
Authors: Atmaja Bisma Budi , Gayatri Annisa Zerlina Cindy , Anugrah Bima Sauma , Sihombing Johanes Saut Marganda 
Published: February 2024

ABSTRAK
Tindak Kejahatan yang ada di Indonesia saat ini semakin beragam. Hal tersebut seiring dengan adanya perkembangan zaman. Salah satu kejahatan yang ada di Indonesia dan berdampak besar terhadap negara yaitu kejahtan korupsi dan kejahatan Tindak Pidana Pencucian Uang. Kejahatan tindak pidana pencucia uang di Indonesia semakin banyak. Para pelaku tindak pidana melakukan kejahatan yang dilarang dan bertentangan dengan hukum, kemudian keuntungan yang di dapatkan dari kejahatan tersebut diolah agar tidak diketahui bahwa harta itu merupakan harta hasil dari tindak pidana. Beragam cara dilakukan oleh pelaku agar uang tersebut tidak diketahui bahwa uang hasil tindak kejahatan, berbagai cara yang dilakukan dalam pencucian uang diantaranya mentransfer uang tersebut ke luar negeri kemudian diambil kembali untuk membangun perusahaan, uang hasil kejahatan ditanamkan sebagai modal perusahaan, disimpan dalam saham perusahaan. Pencucian uang yang dilakukan di luar negeri akan menyangkut banyak pihak. Dalam mengatasi permasalahan tersebut, diatur berdasarkan asas nasional aktif di Indonesia. Asas nasional aktif itu ada di ketentuan KUHP. Kejahatan tindak pidana korupsi dan pencucian uang harus ditangani dengan serius karena tindak pidana terseut merugikan keuangan negara. Salah satu kasus tentang kejahatan tindak pidana korupsi dan tindak pidana pencucian uang di Indonesia dilakukan oleh Nazaruddin sebagai anggota DPR. Nazaruddin melakukan suap pada proyek wisma atlet dan melakukan tindakan pencucian uang dengan membawa uang tersebut ke luar negeri lalu membawa kembali ke Indonesia dan digunakan sebagai modal saham perusahaan. Nazaruddin melarikan diri ke luar negeri dan bersembuyi dibeberapa negara, akan tetapi keberadaannya bisa diketahui sehingga dipulangkan dari negara yang menjadi tempat persembunyiannya dan kembali ke negara Indonesia untuk menjalani proses hukum.
Attitude of clinical teachers towards the use of innovative technology in teaching and learning in the university of Port Harcourt medical school, South Nigeria
Authors: Wananyo Ugboma Enighe , Ebi Awotua-Efebo , Ibi Erekosima 
Published: February 2024

The 21st century has seen a rapid increase in the use of various innovative technologies in pedagogy. The attitude of the clinical teachers affects the use of these innovative technologies in teaching and learning. The aim of this research is to find out the attitude of clinical teachers using “The Tripartite Theory of Attitude” consisting of affective, cognitive, and behavioral domains, to the use of innovative technology. A descriptive survey research design with correlational studies was done with a purposive sampling method used. A 24 item Likert questionnaire was used and distributed using Google Form. The population of the study was made up of clinical teachers in the Faculty of Clinical Sciences University of Port Harcourt. A total of 90 clinical teachers took part in the study comprising of 48 males and 42 females. 23 were professors while 51 were senior lecturers. Analysis showed the overall attitude of clinical teachers to the use of innovative technology in teaching and learning was positive. No significant correlation was seen between gender, cadre, and years of service of the clinical teacher to the use of innovative technology. Thus, incorporation of innovative technology into the classroom should be encouraged as this would aid the clinical teachers in improving learning in the classroom.
RETRACTED: The impact of COVID-19 news on the mental health of Bahrainis
Authors: Aldoseri Marwa , Alhadi Noora , Alghatam Latifa , Abdulla Shoog , Alrayes Hala , Aldoseri Fajer , Almudahka Danat , Hasan Retaj , Shareeda Shoog , Alzobbae Lena , Almarabheh Amer , Ahmed Jamil 
Published: February 2024

Abstract
The authors have requested that this preprint be removed from Research Square.
Kunzea ericoides (kanuka) leaf extracts show moisturisation, anti-oxidant, and UVB-protection effects in HaCaT cells and anti-melanogenesis effect in B16F10 cells
Authors: He Xuefeng , Li Peishan , Zhao Shixin , Liu Hengdeng , Tang Weijian , Xie Julin , Tang Jinming 
Published: February 2024

Abstract

The present study identified various compounds, such as chlorogenic acid, gallic acid, quercetin, and (E)-Ferulic acid in the kunzea ericoides (kanuka) leaf extract, showing its potential use in maintaining skin health. The influence of kanuka leaf extract upon epidermal cells concerning cytotoxicity and in vitro activities of moisturisation, anti-oxidation, UVB protection, and anti-melanogenesis effects were explored in the study. Kanuka leaf extract demonstrated significant promotion in the proliferation of HaCaT and B16F10 cells. After incubation with kanuka leaf extract, the content of ROS and DPPH in HaCaT was significantly decreased; at the same time, more SOD was produced. Furthermore, hyaluronidase-1 (HYAL-1) and HYAL-4 expressions were inhibited, while the aquaporin 3 (AQP-3) content was significantly increased. Kanuka leaf extract also inhibited the expressions of matrix metalloproteinases-1 (MMP-1) and MMP-14 in UVB radiated-HaCaT cells. In the B16F10 cell line, melanin and tyrosinase production were decreased under the presence of kanuka leaf extract, and the expressions of microphthalmia-associated transcription factor (MITF), tyrosinase-related protein-1 (TYRP-1) and TYRP-2 were also inhibited.
Uncertain programming model for fixed charge multi-item solid transportation problem with compensate for loss.
Authors: Zhao Yunpeng , Liu Xue Ling , Wang Hongwei , Liu Xue , Liu Liying 
Published: February 2024

Abstract
In this paper, the solid transportation problem with fixed rate and loss compensation is studied, in which the loss compensation includes the reissue cost and the loss compensation cost. Since there are a lot of indeterministic factors in the whole transportation process, it is assumed that the supply, demand, loss, fixed charge, and transportation volume in the model are regarded as uncertain variables. An expected value model and a chance-constrained model are constructed using the expectation value criterion and the chance constraint criterion, respectively. The particle swarm optimization and seagull optimization algorithms calculate the optimal results of the two models. The advantages and disadvantages of these two algorithms are analyzed using the analytic hierarchy process. Finally, numerical experiments show the application of the model.
The role of the Golden2-like (GLK) transcription factor in regulating chlorophyll and terpenoid indole alkaloid biosynthesis in Catharanthus roseus
Authors: Cole-Osborn Lauren F. , McCallan Shannon A. , Prifti Olga , Abu Rafay , Sjoelund Virginie , Lee-Parsons Carolyn 
Published: February 2024

Abstract

Catharanthus roseus is the sole source of the chemotherapeutic terpenoid indole alkaloids (TIAs) vinblastine and vincristine. TIAs are produced at higher levels in immature versus mature leaves, but the molecular mechanisms responsible for this developmental regulation are unknown. We investigated the role of GOLDEN2-LIKE (GLK) transcription factors in contributing to this ontogenetic regulation since GLKs are active in seedlings upon light exposure and in the leaf’s early development, but their activity is repressed as leaves age and senesce. We identified a GLK homologue in C. roseus and functionally characterized its role in chlorophyll and TIA biosynthesis by transiently reducing its expression through two separate methods: virus-induced gene silencing and application of chloroplast retrograde signaling inducers, norflurazon and lincomycin. These experiments confirmed that CrGLK positively regulates chlorophyll biosynthesis and the expression of the light harvesting complex subunit (LHCB2.2), consistent with its function in other plant species. In contrast, reducing CrGLK increased TIA accumulation and TIA pathway gene expression, specifically vindoline biosynthesis, suggesting that it may instead repress TIA biosynthesis. Interestingly, while lincomycin treatment led to significant increases in TIA gene expression, norflurazon had no effect, suggesting that reducing CrGLK alone was not sufficient to induce TIA biosynthesis, and providing a clue for future investigations of TIA regulation. This is the first identification and characterization of GLK in C. roseus and the first investigation of how chloroplast retrograde signaling might regulate TIA biosynthesis.
Assessment of Different Strategies for ROI-Based Measurements of Proton Density Fat Fraction in NAFLD
Authors: Lu Jingyi , Xia Youchen , Mu Rong , Luo Qian , Zhang Lei , Zhu Kouyun , Cai Xiaobo , Lu LunGen , Qu Ying 
Published: February 2024

Abstract

Aims:

MRI-PDFF is a promising non-invasive method of quantifying liver fat. This study assessed the reproducibility and repeatability of MRI-based PDFF in NAFLD patients, the consistency between different ROI sampling strategies, as well as the learning time burden of PDFF measurement.

Methods:

90 NAFLD patients and 30 healthy people were enrolled in this cross-sectional study. Three reviewers measured liver PDFF by circling ROIs in four segments, nine Couinaud segments, and a random place on the PDFF map, respectively. Bland-Altman analysis and ICC were used to evaluate the inter- and intra-reviewer agreements for liver PDFF.

Results:

Circling ROIs within nine Couinaud segments had the narrowest limit of agreement (LOA) for PDFF measurements. For all 120 subjects, the intra-reviewer agreement had mean LOA of ±0.9% for three strategies, while the inter-reviewer agreement had mean LOA of ± 0.93%. We additionally determined that inter-group consistency increased with decreasing liver fat content for all ROI-circling strategies. The CUSUM learning curve shows that after 17 cases, beginners circled the ROIs more efficiently and accurately.

Conclusions:

Researchers and clinicians can circling one random ROI for mass screening of patients with NAFLD. We suggest training beginners perform at least 17 PDFF maps to acquire reliable data.
Wnt signaling alters CTCF binding patterns and global chromatin structure
Authors: Cantù Claudio , Nordin Anna , Chakraborty Chaitali , Jonasson Mattias , Dano Orgena , Zambanini Gianluca , Pagella Pierfrancesco , Remeseiro Silvia 
Published: February 2024

Abstract
Wnt signaling plays a pivotal role during development, stem cell maintenance, and tissue homeostasis. Upon Wnt pathway activation, β-catenin translocates to the nucleus where it binds the TCF/LEF transcription factors to drive the context-specific expression of Wnt target genes. Coordinating gene expression programs in vertebrates requires a complex interplay between the regulatory and the 3D organization of the genome. However, the impact of Wnt signaling on genome structure has been poorly explored. Here we investigated how Wnt signaling activation influences the binding patterns of CTCF, one of the core architectural proteins that helps establish the 3D genome organization by demarcating topologically associated domains (TADs). This study uncovered a series of CTCF rearrangements under Wnt, that we termed RUW. Notably, RUW sites that were gained upon Wnt activation were typically dependent on β-catenin and were characterized by both CTCF and TCF/LEF binding. Accordingly, many CTCF RUWs aligned with β-catenin binding patterns, and β-catenin and CTCF co-localized in vivo in discreet nuclear puncta only upon pathway activation. Genome-wide investigation of CTCF-mediated 3D genomic interactions upon Wnt pathway stimulation supported the role of the identified RUWs in mediating Wnt-dependent chromatin loops. Lastly, targeted disruption of selected CTCF binding sites demonstrated their functional contribution to Wnt target gene regulation, implicating regulation of the 3D genomic structure in the execution of transcriptional programs orchestrated by developmental pathways.
Investigation on the pollution status of hand washing facilities in use on the surrounding environment
Authors: wang xueyu , TIAN Fang-Ying , Meng haopeng , Kang jianbang , Zhao ming , Wang hongwei 
Published: February 2024

Abstract
Aim To detect the pollution of faucets in hospitals and the splash during hand washing, and to explore the reasonable layout of hand washing pools.
Methods Two faucets with roughly the same spatial layout in the ICU of a third-class first-class general hospital were selected, and the farthest splashing distance and specific splashing points were measured by color paper. Samples were detected by ATP detection technology and routine microbial detection method, and the pollution of faucets was analyzed.
Findings After 72h of daily hand-washing activities, the furthest distance to the splash point was about 100cm around the faucet, and the place 40cm-110cm around the faucet was polluted seriously. The farthest distance that the splash point reached was about 80cm around the faucet with the center of the circle, and the area 40cm-60cm around the faucet was heavily polluted. The distance from the water outlet of the long handle and the short handle faucet to the detection point had a high negative correlation (r = − 0.811, P<0.001) and a moderate negative correlation (r=−0.475, P=0.001) with the number of splash points, respectively. The qualified rates of ATP detection and microbial culture were 25% and 15%, respectively. Pseudomonas aeruginosa, Staphylococcus epidermidis, and other pathogenic bacteria were detected in the water outlet of the faucet and the surrounding environment.
Conclusion Safe hand-washing facilities are the guarantee of hand hygiene effect. Clean objects and objects related to patients should not be placed within 1m range near the water outlet of faucet. Anti-splash baffle should be installed as much as possible when conditions permit to reduce the pollution caused by splash during hand washing.
Reteplase-induced Hypotension in Patients Undergoing Thrombolysis in Acute Myocardial Infarction- Case Series
Authors: S Arun , Gudge Rahul , Lal Hina , Vartha Shoban Babu , Ambwani Sneha , Deora Surender , singh Surjit 
Published: February 2024

Abstract

Introduction:
Reteplase is the second-generation tissue plasminogen activator used as a thrombolytic agent for myocardial infarction patients. It has better tolerability as compared to streptokinase. Bleeding is one of the recorded side effects of reteplase.
Case presentation:
In this case, a series of 2 patients noticed an incidence of hypotension after the infusion of the Reteplase with an average onset in 20- 30 minutes after the first dose of Reteplase. Of the two patients encountered with the event of hypotension secondary to Reteplase, a 68-year-old male was diagnosed with anterior wall MI, and a second patient of age 55 years old, was diagnosed with anterolateral wall MI. Reteplase-induced hypotension is relatively uncommon in the literature and documented reports. All patients recovered in the period.
Conclusion:
Two patients encountered hypotension after the infusion of Reteplase can come under “Possible” adverse drug reaction according to the WHO causality assessment. The possible mechanism of action for the incidence of hypotension post-thrombolysis or during thrombolysis may be assigned to releasing the inflammatory mediators secondary to the hypersensitivity reaction. Both Patients recovered with the symptomatic therapy.