bluuebunny/crossref_metadata_2025_split huggingface dataset:
Multimodal neuromonitoring of a brain death with electrophysiological markers of cortical and subcortical loss of functions
Authors: Ghibaudo Valentin , Bado Jules , Garcia Samuel , Berthiller Julien , Rithzenthaler Thomas , Gobert Florent , Bapteste Lionel , Carrillon Romain , Bodonian Carole , Dailler Frédéric , Haegelen Claire , Dumot Chloé , Rheims Sylvain , Berhouma Moncef , Balança Baptiste 
Published: January 2024

Abstract
Brain death, characterized by the permanent cessation of all brain functions including the brainstem, is subject to varying diagnostic criteria internationally. In France, the confirmation of the clinical criteria requires ancillary tests such as CT angiogram or EEG. The timing of these tests presents challenges, especially in the intensive care setting. This study outlines a novel approach for the assessment of brainstem and cortical functions, improving the precision of brain death diagnosis in high-workload intensive care environments. We detail the implementation of a continuous multimodal neuromonitoring system, utilizing electrocorticography to monitor cortical spreading depolarizations (SD) and employing advanced analytics to track variability in heart and respiratory rates as indicators of brainstem functions. The SD-ICU single-center trial assessed the feasibility and safety of SD monitoring in patients with acute brain injuries, using cortical electrodes. In conjunction with the Moberg CNS monitor, this setup allowed for the collection and analysis of multimodal neuromonitoring data. We highlight the case of a patient who, exhibited an SD-initiated negative ultraslow potential, indicating cortical death. Subsequent fluctuations in heart and respiratory rates’ variability provided a real-time evaluation of the functionality of the brainstem's cardiovascular and respiratory centers. The integration of SD monitoring and variability analyses offers a continuous bedside evaluation, presenting clinicians with real-time biomarkers of brainstem and cortical death. This method could be incorporated into neuromonitoring software, enabling more timely and precise brain death determinations, a paramount improvement given the complexities and demands of ICU care.
Resolution improvement of incoherent optical point sources by using modes selection in microsphere imaging
Authors: Zhou Song , Qian Fang , Wang Yimin 
Published: January 2024

Abstract
Spatial-mode demultiplexing (SPADE) scheme has been successfully used in quantum Cramer-Rao bound for resolution of two incoherent optical point sources. In this work, we investigate resolution of point sources by a microsphere. Based on the spatial-mode demultiplexing scheme, we find that the resolution of the point sources can be improved using modes selection. Then, we present an executable method to realize modes selection in far-field domain for improving the resolution of the point sources under a microsphere. Our results will be helpful to improve the contrast and resolution of microsphere super-resolution imaging.
Evaluation of the antiproliferative and oxidative effects of polymeric cryogels on the model eukaryotic yeast Saccharomyces cerevisiae
Authors: Yardımcı Berna Kavakcıoğlu , Şarkaya Koray , Güler Ayşenur 
Published: January 2024

Abstract
Here, the effects of previously characterized poly(HEMA-N-vinyl formamide) (PHEMA-NVF) cryogels on viability, surface morphology, total antioxidant-oxidant status, antioxidant enzyme activities and biochemical makeup of Saccharomyces cerevisiae were investigated for the first time. The viability of the cells released from the PHEMA-NVF cryogels were found to decrease dramatically up to 23.96 ± 1.44% compared to the plain PHEMA cryogel as control group without NVF. Additionally, this cryogel caused blebbing and holes on the cell surface. Although TOS levels gradually increased with the increasing amounts of NVF, statistically significant difference was determined only between the cryogel containing 22 µl NVF and control. The gradual increases in TAS levels in response to cellular stress were recorded depend on the increase of NVF amounts up to 22 µl. While enzymatic antioxidant system was generally induced in cells released from the cryogel prepared with relatively low levels of NVF, these activities dramatically decreased at the higher amounts of the comonomer. Finally, FTIR analysis showed that especially the highest studied concentration of NVF caused protein degradation and increase the relative concentration of lipid and polysaccharide molecules. Therefore, it can be suggested that this comonomer causes oxidative stress that the cell cannot cope with above a certain amount.
A multiphase mixed-methods participatory approach to Paramedicine educators’ identity, intersectionality, and impediments to professional emergence
Authors: Naidoo Navindhra , Maria Sonja , Flanagan Belinda , Noordenburg Andrew Van , Ho Vincent , Mansour Victoria 
Published: January 2024

Abstract
Background
This research delves into how identities and philosophies of paramedicine educators influence theoretical advancement and praxis in higher education.
Purpose
It examines the perceptions of paramedicine academics, their roles and the transitional challenges when moving from clinical practice to academia. It explores the potential of transformative pedagogy in fostering social consciousness, justice, and innovation. Challenges and benefits of a constructivist approach to paramedicine education and future-orientation is assessed.
Methods
Employing a multiphase mixed-methods participatory approach, researchers reached consensus on the guided themes (Phase 1) for staff collaborative engagement (Phase 2) during the inaugural ‘Paramedicine Educators Forum’ in December 2022, which featured participation of academic leaders and staff from four universities and one jurisdictional ambulance service.
Results
The study unveils the intricate tapestry of paramedicine educators' identities and philosophies and their impact on theoretical advancements and practical applications in higher education. Conversations revolved around defining the role of paramedics in academia, the potential of transformative pedagogy, and the balance between producing competent paramedics whilst nurturing critical thinkers. Discussions also addressed the shortcomings of current undergraduate degrees in preparing students for technological advancements and the potential for extended degree programs.
Conclusion
The findings underscore the need to adapt paramedicine education to meet the evolving demands of the profession, with paramedicine educators playing a leading role in this transformation. These insights may be instructive in providing guidance for educational policies and practices that shape the future of paramedicine education and may have transferability for other allied health professions.
Impact of Sarcopenia on the Prognosis of Patients with Advanced Non-small Cell Lung Cancer Treated with Anti-angiogenic Therapy: A Propensity Score Matching Analysis
Authors: Huang Fuchun , Ma Mingxuan , Yang Shuang , Zhao Hui , Zhang Jialin , Lang Liye , Liu Hua 
Published: January 2024

Abstract

Background Limited information is available regarding the impact of sarcopenia on the prognosis of antiangiogenic therapy in individuals with advanced non-small cell lung cancer (NSCLC). This study primarily sought to examine the prognostic significance of sarcopenia in individuals with advanced NSCLC undergoing anti-angiogenic therapy. Methods We retrospectively collected all patients who met the inclusion and exclusion criteria from 2019 to 2021 at Nantong University Hospital. Patients were grouped according to the presence or absence of sarcopenia. After propensity score matching (PSM), progression-free survival (PFS), overall survival (OS), and adverse event rates were compared between the two groups. Factors associated with prognosis were screened using univariate and multivariate analyses. Results A total of 267 patients were included, with a total of 201 matched at baseline after PSM (77 in the sarcopenia group and 124 in the non-sarcopenia group). The sarcopenia group had lower PFS (p = 0.043) and OS (p = 0.011) than the non-sarcopenia group and a higher incidence of adverse events (p = 0.044). Multivariate analysis suggests that sarcopenia is an independent prognostic risk factor for OS in advanced NSCLC patients receiving antiangiogenic therapies (p = 0.009). Conclusion Patients with advanced NSCLC with comorbid sarcopenia gravis exhibit a worse prognosis when treated with anti-angiogenic therapy, and preventing and ameliorating sarcopenia gravis may lead to better survival outcomes in patients with advanced NSCLC.
School starting age and mothers’ labour supply: Causal evidence from the 2012 Education Reform in Turkey
Authors: Zayim Gülen Derya , Kayaoğlu Ayşegül 
Published: January 2024

Abstract
The 2012 Education Reform has significantly transformed the education system in Turkey in various ways. It extended compulsory schooling to 12 years, replacing a discrete structure across educational levels. As a part of this change, the primary school starting age has been adjusted, allowing up to 60-month-old children to be accepted in primary schools. Prior to this reform, the compulsory schooling starting age was seven years old, corresponding to 72-month-old children. By utilizing this exogenous variation in school starting age following the 2012 Education Reform in Turkey, we investigate the impact of childcare cost on maternal labour supply. The results reveal that the reform did not alter the labour supply behaviour of mothers, even after splitting them based on educational attainment or marital status. The findings for married mothers align with previous literature; however, for single mothers, our results, despite being positive in magnitude, are not statistically significant.
JEL Codes: I21, J22
Gender-specific association of Helicobacter pylori infection and the thyroid disease in Chinese adults
Authors: Wei Qiang , Ao Na , Cai Tiantian , Zheng Xiaoya 
Published: January 2024

Abstract
Background
The association of Helicobacter pylori (H. pylori) infection and thyroid disease is still controversial. Chinese adults have an extremely high prevalence of H. pylori infection. The incidence of thyroid diseases has obvious gender difference. The aim of this study was to determine the gender-specific association between H. pylori infection and thyroid disease in Chinese adults.
Design:
Retrospective analyzed the data of subjects underwent routine physical check-up in the Public Health Center of our hospital between 2019 and 2021. The data included anthropometry and blood biochemical indicators. The serum levels thyroid hormones and thyroid autoantibodies were detected. Thyroid ultrasonography was performed by experienced technicians. The diagnosis of thyroid nodules was according to the thyroid imaging reporting and data system (TI-RADS).
Results
The women with positive H. pylori had significantly lower FT4 levels, statistically higher uTSH levels, higher prevalence of hypothyroidism, and higher prevalence of positive TPOAb than the women with negative H. pylori. Men with positive H. pylori had significantly higher SBP, statistically lower TT4 and FT4 than the men with negative H. pylori. The prevalence of thyroid heterogeneous echogenicity and TNs in H. pylori positive and negative subjects had no significant difference in both genders.
Conclusions
The results indicated the prevalence of hypothyroidism and TPOAb positivity was more frequent in females with Helicobacter pylori infection. H. pylori infection may be associated with AITDs in females, but not males. There was no significant association between H. pylori infection and the risk of TNs types in both gender.
Identification and validation of Nei-like DNA glycosylase 2 as a novel prognostic biomarker in cervical cancer
Authors: Li Yan , Du Jiayuan , Wei Lingjia , Tan Tianmeng , Bao Yili , Su Jinqiu , Wang He 
Published: January 2024

Abstract
Background: Cervical cancer causes 270,000 deaths annually. Novel biomarkers and therapeutic targets are urgently needed. NEIL2 is involved in DNA repair and genomic stability maintenance. Its role in cervical cancer is unclear. This study aimed to explore NEIL2 as a novel prognostic biomarker for cervical cancer.
Methods: Bioinformatics analysis was performed on TCGA, GSE7410 and GSE63514 datasets. NEIL2 expression was compared between cervical cancer and normal tissues. Patients were stratified by NEIL2 expression. Survival analysis was conducted. Prognostic factors were identified using Cox regression.
Results: NEIL2 expression was downregulated in cervical cancer. High NEIL2 expression associated with better survival outcomes. Age and histology correlated with NEIL2 expression. High NEIL2 expression, lymph node status and tumor stage were independent prognostic factors. A prognostic nomogram using these factors showed good accuracy.
Conclusions: NEIL2 is a promising prognostic biomarker for cervical cancer.
Impact: Differential NEIL2 expression may serve as an independent risk factor for cervical cancer prognosis. Further validation is warranted.
Clinical and histological impact of diffuse inflammation at pouchoscopy.
Authors: Toritani Kenichiro , Kimura Hideaki , Goto Koki , Matsubayashi Mao , Kunisaki Reiko , Watanabe Jun , Ishibe Atsushi , Otani Masako , Endo Itaru 
Published: January 2024

Abstract
Background
The anatomical location of inflammation in and around the ileal pouch affects the pouch survival rate, and diffuse inflammation have poor pouch survival rates.
Aims
We aimed to clarify the symptoms and histological findings of diffuse inflammation of the pouch.
Methods
We evaluated the symptoms, treatment, and histological findings according to the endoscopic phenotypes of diffuse inflammation, focal inflammation, and normal as the pouch body phenotype, and afferent limb involvement, inlet involvement, cuffitis, and fistula as the peripheral findings.
Results
Of the 318 pouchoscopies, 47 had diffuse inflammation, 201 had focal inflammation and 70 were normal. Symptomatic patients had diffuse inflammation more frequently (46.8%) than focal inflammation (13.4%) and normal (14.2%), with no difference between focal inflammation and normal. Antibiotics and steroids were higher rate administered in cases of diffuse inflammation, but not in cases of focal inflammation or in normal cases. Histological inflammation, inflammatory bowel disease (IBD)-specific finding, and colonic metaplasia showed severity in the order of diffuse inflammation > focal inflammation > normal. The number of peripheral inflammatory findings overlapped in the following order: diffuse inflammation > focal inflammation > normal. The number of symptomatic patients increased as the number of peripheral inflammatory findings increased.
Conclusion
Pouches with diffuse inflammation are more symptomatic, have a higher use of therapeutic agents, and have more severe histological inflammation, IBD-specific finding and colonic metaplasia accompanying peripheral inflammatory findings than the other groups. The higher the overlap of inflammatory findings in the surrounding tissues, the more symptomatic the patients will appear.
The Incidence and Associated Factors of Patient Cancellation Scheduled for Elective Surgery From February to May at Debremarkos Comprehensive Spetialized Hospital, Debremarkos, Northwest Ethiopia, 2022 Gc. A Cross Sectional Study
Authors: Guadie Yitayal , Godie Yohannes , Birhanu Dires 
Published: January 2024

Abstract
Background:
High rates of cancellation of surgical procedures are common in hospital settings which may subsequently lead to economic loss to hospitals besides the burden given to patients, their families, and medical teams. It is well recognized that cancellation of patients from elective theatre operating lists increases cost, decreases efficiency, duplicates workload, and wastes operating room time. Cancellation of elective surgical procedures also causes significant emotional trauma to the patients as well as their families and the community in general, and its impact on hospital resources is great due to prolonged hospitalization and the high cost of health care (1). This study aimed to assess the incidence and causes of patient cancellation scheduled for elective surgery in Debre Markos Comprehensive Specialized Hospital., Debremarkos, Northwest Ethiopia, 2022 GC.
Methods and Materials: A prospective cross-sectional study was conducted on the cancellation of scheduled surgery at Debremarkos Comprehensive Specialized Hospital with a total of 282 sample size from February-01-May-13 consecutive months of 2022 G C. The data was collected from the operating room daily surgical schedule, preoperative anesthesia record sheet, primary physicians, and the anesthetist responsible for the preoperative assessment and conducting the case and by communicating patients if required. Analysis will be done by using SPSS (Version 20). Descriptive as well as analytic statistics are used for variables and data will be presented by tables, graphs, charts, and texts.
Result: A total of 1055 patients were scheduled for elective Surgery in Debremarkos Comprehensive Specialized Hospital. During the study period 282(26.7%) of the patients had their surgery cancelled for various reasons in Debremarkos Comprehensive Specialized Hospital. The two most frequent reasons for cancellation were lack of bed (50.0%) and unfit for anesthesia (15.2%) in DMCSH.
Conclusion and Recommendation: In conclusion, the cancellation rate of scheduled surgeries is high in general adult surgery at Debremarkos Comprehensive Specialized Hospital. The majority of causes are foreseeable and avoidable, and many are related to the hospital itself. We recommend that a facility for hospital preadmission be created.
Bibliometric Analysis of the Top-100 Cited Articles on Postoperative Delirium
Authors: Miao Qingyuan , Zhou Rui , Li Xinyang , Xiong Lize 
Published: January 2024

Abstract
Objective
Postoperative delirium (POD), a common complication affecting short- and long-term prognosis in elderly patients, leads to a heavy burden on social economy and health care. The main purpose of this study is to conduct a bibliometric analysis of the 100 most frequently cited articles on POD.
Methods
“Postoperative delirium” and its synonyms were searched in the Web of Science (WoS) core database. The top-100 cited articles were automatically selected by sorting the records in descending order. Key information such as author, journal, article type, publication year, citations, since 2013 usage count, institution, country, and keywords were extracted and analyzed. VOSviewer software was applied to do the visualization analyses of institution cooperation, author interaction, author co-citation and keywords co-occurrence. The CiteSpace software was used to analyze keywords burst.
Results
Most articles were published by authors and institutions in the United States of America (USA). Inouye was the most influential author of this field. The journals that recorded these articles had a high impact factor (IF), with a highest IF of 168.9 and an average IF of 18.04. Cohort studies were the main document type in this field (42 publications), followed by randomized controlled trial (RCT) and systematic reviews or meta-analysis (18 and 14, respectively). The 10 keywords with highest appearance were “delirium”, “risk-factors”, “surgery”, “confusion assessment method”, “elderly patients”, “hip fracture”, “intensive care unit”, “cardiac surgery”, “general anesthesia” and “risk”. Moreover, “double blind” and “cardiac surgery” were the most recent booming keywords.
Conclusion
We indicated the current research status and tendency of POD by analyzing the 100 most influential articles on POD. The USA is the leader in this field. Prospective study is the preference for authors to cite. Cardiac surgery remains the primary research carrier and the hotspots in the near future may be double-blind studies.
Assessing the viability of Stakeholders’ Engagement in Marine Spatial Planning and its Implications for a Sustainable Blue Economy
Authors: Lukambagire Isaac , Baker Matovu , Manianga Amabile , Bhavani Rao R. 
Published: January 2024

Abstract
Marine spatial planning (MSP) is the key to attaining global ocean sustainability targets related to the blue economy (BE) and inclusive tapping of ocean resources. Although there has been robust progress in promoting MSP, e.g., in the European Union (EU), most countries have yet to develop comprehensive strategies focused on MSP, which could affect fragile ecosystems and vulnerable livelihoods that are already affected by anthropogenic impacts and natural/environmental pressures. Even within the EU, comprehensive MSPs have been developed only in individual countries or specific maritime zones. One of the gaps identified in the literature is related to the limited knowledge of stakeholder engagement in the MSP process. Our study tries to bridge this gap, and we used a mixed research approach—i.e., systematically reviewed 86 articles on MSP—and conducted a key informant interview intending to identify what type of stakeholders or which stakeholders are needed in the MSP process; how, when, and where could they be involved; and how could they impact a sustainable blue economy? The findings revealed that MSP is a systematic process in which different stakeholders are needed at different levels at different temporal and spatial scales. In addition, the approach used to involve stakeholders is required to be based on a given region's governance targets in that region. The study revealed that marine resource user conflicts that hamper sustainable governance and the use of blue economy resources could be solved through MSP. The approach for stakeholder engagement that we bring to the fore in this study could help in the design of more effective participatory conservation interventions that meet ocean sustainability targets.
Effect of Nigella sativa Consumption on Lipid Profile and Glycemic Index
in Patients with Metabolic Syndrome: A Systematic Review and
Meta-analysis of Randomized Controlled Trials
Authors: Shabani Maryam , Ghavidel Farideh , Rajabian Arezoo , Homayouni-Tabrizi Masoud , Jamialahmadi Tannaz , Hosseini Hossein , Sahebkar Amirhossein 
Published: January 2024

Background::
Metabolic syndrome is a multifactorial disorder and genetics,
lifestyle, and aging play important roles in its prevalence. Nigella sativa has several pharmacological
benefits, including anti-inflammatory, antitumor, anti-diabetic, antioxidant,
and hypolipidemic effects. This meta-analysis of randomized controlled trials assesses
the effect of N. sativa consumption on lipid profile and glycemic indices in patients with
metabolic syndrome.

Methods::
We systematically researched Cochrane Library, PubMed, Scopus, and Web
of Science databases. The literature research identified 171 studies with duplication. Of
those, 73 articles were screened for titles and abstracts, and 7 studies were finally selected
for the meta-analysis. Because of the high degree of heterogeneity, we performed subgroup
analyses based on the dose of N. sativa (<=500 mg/day or >500 mg/day).

Results::
The results revealed that N. sativa intake significantly decreased total cholesterol
(SMD: −0.71; 95% CI, -1.44 to -0.38; P = 0.00), LDL-C (SMD: −1.06; 95% CI,
-1.45 to -0.66; P = 0.00) and HDL-C (SMD: −0.31; 95% CI, 0.09 to 0.53; P = 0.01) concentrations.
In addition, N. sativa significantly decreased FBS (SMD: −0.8; 95% CI,
-1.21 to -0.39; P = 0.00) and HbA1c (SMD: −0.37; 95% CI, -0.66 to -0.09; P = 0.01)
concentrations. No publication bias was observed, and sensitivity analysis showed stable
results.

Conclusion::
The current systematic review and meta-analysis indicates that N. sativa
could improve lipid profile and glycemic index in patients with metabolic syndrome.