bluuebunny/crossref_metadata_2025_split huggingface dataset:
Zur Wirksamkeit von Symphytum officinale
Authors: Chrubasik-Hausmann Sigrun , Vlachojannis Julia 
Published: October 2023

SummaryIn der Volksmedizin werden Zubereitungen aus Symphytum officinale zur Wundbehandlung, bei Prellungen und Verstauchungen eingesetzt. Die European Medicines Agency hat 2015 die Datenlage zum Wirkstoff und zu den pharmakologischen und klinischen Studien zusammengefasst und die Beinwellwurzel unter „traditional use“ eingestuft. Das Prädikat umfasst Pflanzenmedizin, die seit mehr als 30 Jahren in Europa angewendet wird. Trotz plausibler Wirksamkeit reichte der Wissensstand nicht für das Prädikat „well-establisheduse“. Dies hätte eine detaillierte Kenntnis des Wirkstoffs erfordert, außerdem einen umfassenden Nachweis für die antioxidative, antientzündliche und wundheilungsfördernde Wirkung sowie für die Wirksamkeit in klinischen Studien. Die vorliegenden Studien weisen auf eine mäßige Evidenz der Wirksamkeit von Zubereitungen aus dem Beinwell bei Sprunggelenksdistorsion, Knie- und Rückenschmerzen. Bei Hämatomen, Dekubitus, stumpfen Traumata ohne und mit Hautabschürfungen gibt es Hinweise auf Wirksamkeit. Beweisend angelegte Studien müssten jetzt die Wirkgrößen bei den einzelnen Indikationen definieren. Beinwell-Zubereitungen, bei denen mithilfe eines Spezialverfahrens die Pyrrolizidinalkaloide entfernt wurden, können ohne Bedenken auch langfristig eingesetzt werden.
Die Alexander-Technik bei chronischen Rückenschmerzen
Authors: Rennschuh Helmuth 
Published: October 2023

SummaryMenschen mit Rückenschmerzen können von der Alexander-Technik profitieren. Sie lernen dabei Innehalten und eine bewusste Neuausrichtung. In dieser Weise finden sie zu einer natürlichen Aufrichtung. Grundsätzlich gilt: Das Natürliche ist in der Regel das Richtige. Dies auszuführen, ist jedoch häufig eine Herausforderung. Eine Studie aus England zeigt Effekte dieser pädagogischen Methode bei Schmerzpatienten.
Relative Match Load in Young Professional Soccer Players during
Soccer-7 and Soccer-11
Authors: Rabano-Munoz Alberto , Suarez-Arrones Luis , Requena Bernardo , Asian-Clemente Jose 
Published: October 2023

AbstractThe aim of this study was to analyze the differences in internal and external
load during Soccer-7 and Soccer-11, comparing positional requirements and
neuromuscular fatigue in both modalities. Twenty-four young soccer players were
monitored in Soccer-7 and Soccer-11 matches using global positioning systems.
Total distance covered (TD), distance covered at high speed (HSR), distance
covered at very high speed (VHSR), peak speed, accelerations (Acc) and
decelerations (Dec) and rate of perceived exertion (RPE) were recorded
differentiating between central backs (CB), midfielders (MF), external players
(EX) and forwards (FW). Neuromuscular fatigue were assessed using a jump test.
During Soccer-11, players showed significantly higher TD, HSR and VHSR, with low
Acc and greater RPE compared with Soccer-7. During Soccer-11, all positions
recorded significantly greater TD, distance at HSR and at VHSR than Soccer-7. In
terms of playing position, CB, MF and FW achieved significantly higher Peak
Speed during Soccer-1, but there was no difference for EX. During Soccer-7 all
positions performed significantly higher numbers of Acc. Although the Soccer-7
modality is considered an optimal format for the development of young soccer
players, there is a significant difference in match running activity for all
playing positions with respect to the Soccer-11 format.
EXERT-BC: Prospective Study of an Exercise Regimen After Treatment
for Breast Cancer
Authors: Champ Colin E. , Peluso Chris , Carenter David J. , Rosenberg Jared , Velasquez Frank , Annichine Adam , Matsko Krista , Hyde Parker N. , Diaz Alexander K. , Beriwal Sushil , Hilton Christie 
Published: October 2023

Abstract
Purpose EXERT-BC is a dose-escalated resistance training regimen created to
improve body composition, strength, and balance in women treated for breast
cancer (BC). Herein, we report the interim analysis. Women treated for BC
underwent this 3-month exercise regimen in an exercise oncology facility with
continual monitoring of load and strength. Twenty women completed the
IRB-approved protocol, with a mean age of 57 years (range 41–74).
Concurrent therapies included anti-estrogen therapy (73%), chemotherapy
(14%), and radiotherapy (23%). 27% of women endorsed
prior exercise. Subjects missed an average of 1.75 classes (range 0–7),
with all meeting adherence over 75%. No injuries or adverse events were
reported aside from muscle soreness and 2 days of knee pain. Significant
differences in body composition at completion included reduced body fat
(38.2% vs. 36.7%, p=0.003), and increased muscle mass
(33.1% vs. 37.1%, p<0.001), functional mobility
screening (9.82 vs. 11.73, p=0.018), and Y-balance (left: 72.4 vs. 85.3,
p=0.001; right: 70.3 vs. 85.2. p<0.001). Significant increases
in load were demonstrated: split squat (p<0.001), trap bar deadlift
(p=0.035), inclined dumbbell press (p<0.001), and bird dog rows
(p<0.001). Dose-escalated resistance training in women with BC is safe
and feasible, endorsing significant improvements across body composition,
balance, and strength.
Synthesis and Characterization of an Eight-Membered Heterocyclic 1,3,5,7-Tetra(3-pyridyl)-1,3,5,7-tetrazacyclooctane
Authors: Li Li , Dai Guo-Liang , Zhu Xue Hua , Yu Lei , Li Hai Yan 
Published: October 2023

Abstract
N,N′-Bis(3-pyridyl)methanediamine was prepared by treating 3-aminopyridine with formaldehyde in acetonitrile. By treating it with formaldehyde, the eight-membered heterocyclic ring compound 1,3,5,7-tetra(3-pyridyl)-1,3,5,7-tetrazacyclooctane was prepared. This could occur in a two-step manner in a [3+1+3+1] cycloaddition reaction. The compounds were characterized by X-ray crystallography, 1H and 13C NMR spectroscopy, and mass spectrometry. The powder XRD pattern of 1,3,5,7-tetra(3-pyridyl)-1,3,5,7-tetrazacyclooctane was also determined and revealed an uncommon twist-crown conformation, which was further confirmed by DFT calculations.
Anti-infective Efficacy of Mechanical Debridement with Adjunctive Modalities on Clinical and Cytokine Parameters in Treatment of Chronic Periodontitis: Randomized Controlled Clinical Trial
Authors: Rajagopal Anjale , Varghese Jothi , Bhat Vinutha , Acharya Vibha , Kamath Vinayak 
Published: October 2023

Abstract
Objectives Periodontal debridement involves conventional scaling and root planing (SRP) along with variant forms of adjunctive therapies. In the present clinical trial, we investigated if the adjunctive use of HybenX gel or diode laser along with SRP could provide a favorable outcome for the treatment of chronic periodontitis.
Materials and Methods The present study involved 60 subjects diagnosed with chronic periodontitis who were randomly assigned as test groups (laser or HybenX) or control group (SRP alone). The primary outcomes of the clinical trial were pocket probing depth (PPD) and clinical attachment level (CAL), which was evaluated at baseline and at third-month time interval. Additionally, secondary outcomes included estimation of reduction in inflammatory mediators interleukin 1β (IL-1β) and tumor necrosis factor α (TNF-α) in gingival crevicular fluid using enzyme-linked immunosorbent assay at baseline and third-month intervals.
Statistical Analysis Normality determination was checked using Shapiro–Wilk test. Since the data was not normally distributed, nonparametric tests were applied. The comparison of clinical parameters between the groups was analyzed with Kruskal–Wallis test. Wilcoxon sign rank test was used to compare the pairwise comparison of clinical parameters among the groups from baseline to third-month follow-up. The inflammatory mediators at various time points were compared using a One-way analysis of variance test, and the inflammatory mediators in each study group were compared using a paired t-test.
Results Both the test groups demonstrated a decrease in PPD and CAL. However, the HybenX group exhibited statistically significant reduction at the end of the third-month study interval compared to the laser group and SRP alone. Further, the secondary outcome IL-1β and TNF-α analysis exhibited statistically significant reduction in all the groups posttherapy.
Conclusion The adjunctive application of HybenX gel yielded an advantage compared to laser and SRP for the treatment of chronic periodontitis.
Clinical Relevance Adjunctive use of the oral tissue desiccant (HybenX gel) combined with SRP improved the periodontal pocket disinfection process and enhanced tissue healing devoid of adverse effects.
Emergence of Drug-Resistant Pathogens in a Neonatal Intensive Care Unit
Authors: Aydınlı Aydın , Sertel Şelale Deniz , Kaya Ayşe Demet 
Published: October 2023

Abstract
Objective Neonatal bloodstream infections (BSIs) due to drug-resistant pathogens are a major cause of neonatal morbidity and mortality. Unfortunately, data regarding the pathogens and their resistance profile are limited in developing countries. The aim of this study was to determine the bacteriological profile and antimicrobial susceptibility patterns in neonatal BSI at a university hospital in Türkiye.
Methods Medical records of neonates with suspected sepsis were retrospectively reviewed during the study period (between January 1, 2018, and December 31, 2020) for demographic data, blood culture, and antimicrobial susceptibility test results.
Results During the study period, 117 BSI episodes were encountered in 106 neonates. The most common pathogen isolated was Staphylococcus epidermidis (n = 86, 73.5%), followed by Klebsiella pneumoniae (n = 11, 9.4%). Methicillin resistance among staphylococci (77/93, 82.8%) and extended-spectrum beta-lactamase (ESBL) production among Enterobacterales (14/17, 82.4%) were common. Gentamicin resistance was detected in 70.1% (54/77) of methicillin-resistant staphylococci and 78.6% (11/14) of ESBL (+) Enterobacterales. Vancomycin and colistin resistance were not detected.
Conclusion The high rate of resistant pathogens encountered in neonatal BSIs underline the importance of constant surveillance of the local pathogens and their antimicrobial susceptibility patterns, which is crucial for implementing appropriate therapy that could save lives and lower the burden of antimicrobial resistance.
Differential Effects of Erythropoietin Administration and Overexpression on Venous Thrombosis in Mice
Authors: Stockhausen Sven , Kilani Badr , Schubert Irene , Steinsiek Anna-Lena , Chandraratne Sue , Wendler Franziska , Eivers Luke , von Brühl Marie-Luise , Massberg Steffen , Ott Ilka , Stark Konstantin 
Published: October 2023

Background Deep vein thrombosis (DVT) is a common condition associated with significant mortality due to pulmonary embolism. Despite advanced prevention and anticoagulation therapy, the incidence of venous thromboembolism remains unchanged. Individuals with elevated hematocrit and/or excessively high erythropoietin (EPO) serum levels are particularly susceptible to DVT formation. We investigated the influence of short-term EPO administration compared to chronic EPO overproduction on DVT development. Additionally, we examined the role of the spleen in this context and assessed its impact on thrombus composition.
Methods We induced ligation of the caudal vena cava (VCC) in EPO-overproducing Tg(EPO) mice as well as wildtype mice treated with EPO for two weeks, both with and without splenectomy. The effect on platelet circulation time was evaluated through FACS analysis, and thrombus composition was analyzed using immunohistology.
Results We present evidence for an elevated thrombogenic phenotype resulting from chronic EPO overproduction, achieved by combining an EPO-overexpressing mouse model with experimental DVT induction. This increased thrombotic state is largely independent of traditional contributors to DVT, such as neutrophils and platelets. Notably, the pronounced prothrombotic effect of red blood cells (RBCs) only manifests during chronic EPO overproduction and is not influenced by splenic RBC clearance, as demonstrated by splenectomy. In contrast, short-term EPO treatment does not induce thrombogenesis in mice. Consequently, our findings support the existence of a differential thrombogenic effect between chronic enhanced erythropoiesis and exogenous EPO administration.
Conclusion Chronic EPO overproduction significantly increases the risk of DVT, while short-term EPO treatment does not. These findings underscore the importance of considering EPO-related factors in DVT risk assessment and potential therapeutic strategies.
ACOX1 Gain-of-Function Variant in Two German Pediatric Patients, in One Case Mimicking Autoimmune Inflammatory Disease
Authors: Thiels Charlotte , Lücke Thomas , Rothoeft Tobias , Lukas Carsten , Nguyen Huu P. , von Kleist-Retzow Juergen-Christoph , Prokisch Holger , Grimmel Mona , Haack Tobias B. , Hoffjan Sabine 
Published: October 2023

AbstractMitchell syndrome is a very rare genetic disorder due to a specific de novo gain-of-function variant in acyl-CoA oxidase 1 (ACOX1). So far, only five patients with this disease have been described worldwide. We present here two additional unrelated German patients found to carry the same heterozygous ACOX1 N237S variant through exome sequencing (ES). Both patients showed neurodegenerative clinical features starting from ∼4 to 5 years of age including progressive hearing loss, ataxia, ichthyosis, as well as progressive visual impairment leading to amaurosis, and died at the ages of 16 and 8 years, respectively. The first patient was clinically suspected to have anti–myelin oligodendrocyte glycoprotein-antibody-associated myelitis, but the disease course overall deteriorated despite extensive immunomodulatory therapy. The second patient was originally suspected to have a mitochondrial disorder due to intermittent elevated blood lactate. Since Mitchell syndrome has only been identified in 2020, the diagnosis in this second patient was only established through re-evaluation of ES data years after the original analysis. Comparison of all seven reported patients suggests that Mitchell syndrome often (but not always) clinically mimics autoimmune-inflammatory disease. Therefore, in patients with autoimmune central nervous system disease who do not respond adequately to standard therapies, re-evaluation of this diagnosis is needed and genetic analyses such as trio ES should be considered.
The low-lying electronic states and ultrafast relaxation dynamics of the monomers and J-aggregates of meso-tetrakis (4-sulfonatophenyl)-porphyrins
Authors: Fang Hui , Wilhelm Michael J. , Kuhn Danielle L. , Zander Zachary , Dai Hai-Lung , Petersson George A. 
Published: October 2023

The electronic and vibrational spectra of the meso-tetrakis(4-sulfonatophenyl)-porphyrins (TSPP) have been studied computationally using the PFD-3B functional with time-dependent density functional theory for the excited states. The calculated UV-vis absorption and emission spectra in aqueous solution are in excellent agreement with the experimental measurements of both H2TSPP−4 (monomer) at high pH and H4TSPP−2 (forming J-aggregate) at low pH. Moreover, our calculations reveal an infrared absorption at 1900 cm−1 in the singlet and triplet excited states that is absent in the ground state, which is chosen as a probe for transient IR absorption spectroscopy to investigate the vibrational dynamics of the excited state. Specifically, the S2 to S1 excited state internal conversion process time, the S1 state vibrational relaxation time, and the lifetime of the S1 excited electronic state are all quantitatively deduced.
Sewage-derived nitrogen dispersal and N-fixation in Port Phillip Bay in south-eastern Australia
Authors: Parry Gregory D. , Black Kerry P. 
Published: October 2023

Context Extreme values of nitrogen isotope ratios (δ15N) in biota identify areas influenced by sewage discharges and nitrogen fixation. Aims To measure the ecological footprint of the Western (sewage) Treatment Plant (WTP) by using δ15N measurements and an NPZ model, and to identify regions where nitrogen is fixed in Port Phillip Bay, in south-eastern Australia. Methods δ15N was measured in situ for four intertidal species at 27 sites around the perimeter of the bay and simultaneously in an alga and a mussel deployed at 42 sites throughout the bay. The intertidal species were also transplanted from an area of low 15N to areas of high 15N. Key results δ15N was elevated for all species adjacent to the WTP and along the north-western shoreline of Port Phillip Bay and for ~10–15 km offshore. Transplanted algae adopted the δ15N of their new environment in 6–12 weeks, whereas the half-life of tissue turnover of 15N in intertidal filter-feeders was 90–234 days. Nitrogen fixation contributed to N available in two geographically isolated seagrass-dominated bays. Conclusions Spatial patterns of δ15N of deployed alga and phytoplankton-consuming mussels were similar to the modelled distribution of dissolved inorganic nitrogen and the modelled distribution of flagellates, respectively. Implications Preferred species for on-going N monitoring are identified.
Estimating the effectiveness of using wildlife cameras versus visual-encounter surveys to detect herpetofauna
Authors: Brown Ally K. , Hannon Devyn A. , Maerz John C. 
Published: October 2023

Context Efficient monitoring of herpetofauna can prove challenging to agencies and NGOs responsible for their management. Wildlife cameras have been proposed as a method to monitor herpetofauna; however, estimates of detection rates and factors affecting detection by cameras are generally lacking and therefore limiting their application. Aims We determined the effect of body size and temperature differential on the detection of snakes and frogs by passive infrared (PIR) wildlife cameras. We hypothesised that detection would differ among models and be positively correlated with body size and surface-temperature differential between the animal and substrate. We then conducted a field study to compare the detection of herpetofauna by a traditional method with PIR cameras. Methods We tested 10 cameras of seven models on five snakes and one camera on six frogs. Photographs were downloaded to determine the detection rate of each species by each camera. We then chose a camera model to compare two herpetofauna survey methods, namely, drift fences equipped with cameras and visual-encounter surveys. Surveys were conducted monthly over 12 months in Irwin County, GA, USA. Key results The highest mean detection rates of snakes were 0.65 (s.e. = 0.33), 0.50 (s.e. = 0.34), and 0.49 (s.e. = 0.34) for the Browning Dark Ops, Reconyx Hyperfire 2, and Mossy Oak Covert Scouting Camera respectively. The detectability of larger snakes was greater than that of smaller snakes and increased as the absolute temperature differences between the snake and the substrate increased. The detectability of frogs was influenced by absolute temperature differential alone. PIR cameras generated five times more observations, documented more herpetofauna species, and were seven times more efficient than traditional surveys. Conclusions The effectiveness of PIR cameras to detect herpetofauna varies among models and depends on the likelihood that the animal will have a body temperature significantly different from the temperature of the substrate. PIR cameras generated observations far more efficiently than traditional sampling methods. Implications PIR wildlife cameras may be most effective at detecting larger, diurnal herpetofauna and least effective at detecting smaller, nocturnal species. Wildlife cameras have the potential to efficiently monitor some herpetofauna, providing a means to better evaluate management objectives.
Thermodynamical properties of an ideal gas in a traversable wormhole
Authors: Araújo Filho A A , Furtado J , Reis J A A S , Silva J E G 
Published: October 2023

Abstract
In this work, we analyze the thermodynamic properties of non-interacting particles under influence of the gravitational field of a traversable wormhole. In particular, we investigate how the thermodynamic quantities are affected by the Ellis wormhole geometry, considering three different regions to our study: asymptotically far, close to the throat, and at the throat. The thermodynamic quantities turn out to depend strongly on parameter that controls the wormhole throat radius. By varying it, there exist an expressive modification in the thermodynamic state quantities, exhibiting both usual matter and dark energy–like behaviors. Finally, the interactions are regarded to the energy density and it seems to indicate that it ”cures” the dark energy–like features.
I–V analysis for nuclear-excited low-temperature plasmas in porous metals
Authors: Lo Austin , Bernstein Lee 
Published: October 2023

Abstract
We demonstrate how a high surface-to-volume ratio porous electrode structure within an ionizing radiation field generates a nuclear-excited low-temperature plasma source. In a foundational experiment, we compared the I–V characteristics of two electrode systems comprised of: (1) open-cell reticulated copper foam discs (pore radius ∼500 µm) and (2) solid copper discs. Both systems were held at 2 atm neon and irradiated in a nuclear reactor under steady-state operation. The primary source of plasma ionization was electrons derived from reactor γ-rays; the secondary source was electrons from the β
− decay of 64Cu and 66Cu formed by the capture of thermal neutrons. The two electrode systems exhibited identical I–V proportionality for applied voltages between 2 V and 5 V, evidencing a sheath structure evolving within the copper foam discs. The energy fraction absorbed in the gas per unit electrode mass was 20%–70% greater for the porous electrode than for the solid electrode, corresponding to a factor of 3.5 increase in the specific ion output current [A g−1]. The plasma densities achieved in the porous and solid electrode systems were estimated to be

(
3.2
−
3.9
)
×

10

9

cm−3 and

7.1
×

10

9

cm−3 respectively, assuming a spatially independent density profile and approximately ambient electron temperature.
Uni-axial reinforced dielectric elastomer actuators with embedded 3D printed fibers
Authors: Konstantinidi Stefania , Martinez Thomas , Tandon Biranche , Civet Yoan , Perriard Yves 
Published: October 2023

Abstract
Dielectric elastomer actuators (DEAs) can be described as compliant capacitors formed by a dielectric elastomer film sandwiched between two electrodes. An applied voltage results in a compressive Maxwell stress, a thickness reduction and thus an expansion in the other dimensions. In order to favor large uni-axial deformations, it is predicted that DEAs ought to be constrained in the other direction. This can be achieved by reinforcing the DEA with unidirectional fibers. In this paper, the behavior of uni-axial fiber-reinforced DEAs is established and the proposed model innovates by taking into consideration the fiber properties such as their Young’s modulus and dimensions, and is characterized by transversely isotropic models. A novel fabrication process is then presented for reinforced DEAs by using 3D printed fibers with four different materials, namely Nylon, PETG, ABS and PLA, and different coverages of fibers are considered. Fiber reinforcement is shown to increase uni-axial strain up to 75% in the manufactured DEAs when compared to traditional DEAs. This behavior corresponds to the one predicted by the proposed model.