bluuebunny/crossref_metadata_2025_split huggingface dataset:
The usability of virtual reality to train individuals in responding to behaviors related to dementia
Authors: Garcia Linda , Robitaille Annie , Bouchard Stéphane , Rivard Marie-Christine , McCleary Lynn 
Published: January 2024

IntroductionDementia is associated with several behavioral changes globally referred to as Behavioral and Psychological Symptoms of Dementia (BPSD) of which many are recognized to be the expression of unmet needs triggered by environmental factors. BPSD are an extreme source of stress for family care partners and health care providers alike and can be the reason why people living with dementia (PLWD) are placed in long-term care homes (LTCH). The overall goal of this project was to examine whether a virtual environment that includes a virtual LTCH resident with dementia in a lifelike situation could be useful and usable for health care providers and care partners to identify potential triggers to BPSDs while being engaged emotionally with the scenario.MethodsTwenty-three health care professionals working with PLWD, 25 care partners to PLWD, 27 students in a health-related field, and 11 university/community college faculty members teaching courses relevant to gerontology tested the application which depicted a meal-time scenario. In addition to being asked about the behavioral triggers in the scene, participants were asked about the usefulness and usability of the tool for training. Presence and simulator sickness were also measured.ResultsResults suggest that participants generally felt present and emotionally engaged. They could identify the potential triggers for the observed behaviors in the virtual human with dementia as well as suggest some solutions. The majority (87% of participants) found the tool easy to use. Many participants identified the inability to interact with the virtual humans as a shortfall, and few reported mild to moderate levels of simulator sickness.DiscussionAs the behavioral changes associated with dementia can cause extreme stress for those interacting with PLWD, developing an effective and efficient training tool could significantly improve well-being for all involved. The investigators see the development and testing of an interactive version of this virtual environment as a next step in making this a clinically relevant training tool.
Vhl deletion in Dmp1-expressing cells alters MEP metabolism and promotes stress erythropoiesis
Authors: Emery Janna M. , Chicana Betsabel , Taglinao Hanna , Ponce Citlaly , Donham Cristine , Padmore Hawa , Sebastian Aimy , Trasti Scott L. , Manilay Jennifer O. 
Published: January 2024

IntroductionErythropoiesis occurs in a specialized niche in the bone marrow and is regulated in part by oxygen-sensing signaling pathways. VHL is an E3 ubiquitin ligase that regulates the degradation of hypoxia-inducible factor (HIF) proteins under normoxic conditions. In hypoxia, VHL is inactivated resulting in enhancement of HIF signaling. Methods and resultsTo investigate the effects of HIF-activation in bone cells on erythropoiesis, we performed longitudinal analyses of conditional Vhl knockout mice (Dmp1-Cre;Vhlfl/fl; VhlcKO) mice, in which Vhl is deleted primarily in osteocytes but is retained in hematopoietic cells. VhlcKO mice display elevated red blood cell counts and erythropoietin levels starting at 10 weeks of age, resembling polycythemia. Using flow cytometry, we observed increased frequency of CD71loTER119hiFSClo orthochromatophilic erythroblasts and reticulocytes in 10- and 24-week-old VhlcKO bone marrow. Features of extramedullary hematopoiesis were observed in the spleen, including red pulp hyperplasia, the presence of megakaryocytes, and increased frequency of basophilic and polychromatophilic erythroblasts and of mature stress erythroid progenitors. To investigate the mechanisms that drive the accelerated erythropoiesis in the bone marrow, we enumerated myeloid progenitors and observed higher frequencies of megakaryocyte-erythroid progenitors (MEPs) at 6 and 10 weeks of age, but MEP frequency was similar to controls at 24 weeks. Despite this normalization in MEP frequencies, bulk RNA-Seq of MEPs at this age showed upregulation of Epas1 (Hif2a), consistent with a response to hypoxia, as well as genes involved in erythrocyte development. Surprisingly, genes involved in the response to glucose were also upregulated in VhlcKO MEPs. DiscussionOur studies implicate that HIF-driven alterations in skeletal homeostasis drive changes to the bone marrow microenvironment that influence erythroid cell development and MEP metabolism.
An investigation of data from the first year of the interim Canada Dental Benefit for children <12 years of age
Authors: Schroth Robert J. , Cruz de Jesus Vivianne , Menon Anil , Olatosi Olubukola O. , Lee Victor H. K. , Yerex Katherine , Hai-Santiago Khalida , DeMaré Daniella 
Published: January 2024

IntroductionIn 2022, the federal government announced a commitment of $5.3B to provide dental care for the uninsured, beginning with children &lt;12 years of age. Now referred to as the Interim Canada Dental Benefit (CDB), the program targets those &lt;12 years of age from families with annual incomes &lt;$90,000 without private dental insurance. The purpose of this study was to review federal data from the Government of Canada on public uptake and applications made to the Canada Revenue Agency (CRA) during the first year of the Interim CDB.MethodsData for the first year of the Interim CDB (up to June 30, 2023) were accessed from the Government of Canada Open Data Portal through Open Government Licence—Canada. Rates of children receiving the Interim CDB per 1,000 were calculated by dividing the number of beneficiaries by the total number of children 0–11 years by province or territory, available from Statistics Canada for the year 2021.ResultsDuring the first year of the program, a total of 204,270 applications were approved, which were made by 188,510 unique applicants for 321,000 children &lt;12 years of age. Over $197M was distributed by the CRA. Overall, the national rate for receiving the Interim CDB was 67.8/1,000 children. Ontario (82.5/1,000), Manitoba (77.1/1,000), Nova Scotia (73.4/1,000), and Saskatchewan (72.3%), all had rates of children with the Interim CDB above the national rate.ConclusionsData from the first year of the Interim CDB suggests that this federal funding is increasing access to care for children &lt;12 years by addressing the affordability of dental care. Governments and the oral health professions need to address other dimensions of access to care including accessibility, availability, accommodation, awareness, and acceptability of oral health care.
Feasibility and safety of combined laparoscopic and transvaginal oocyte retrieval in a woman with vaginal recurrence of cervical adenocarcinoma: a case report
Authors: Ingold Caroline , Navarro Paula Andrea , de Oliveira Renato , Barbosa Caio Parente , Sadalla José Carlos , Bedoschi Giuliano 
Published: January 2024

IntroductionOocyte cryopreservation is an established technique for fertility preservation in women diagnosed with cancer. However, some clinical scenarios may preclude the commonly used transvaginal approach to oocyte retrieval. In such cases, a laparoscopic approach may be required. Here, we report the feasibility and safety of a combined laparoscopic and transvaginal approach for oocyte retrieval in a woman with vaginal recurrence of cervical adenocarcinoma. This approach allowed for oocyte cryopreservation prior to cancer treatment, representing a novel application in this clinical context.MethodsA 31-year-old woman with endocervical adenocarcinoma underwent laparoscopic radical hysterectomy and pelvic lymph node dissection. She presented with vaginal recurrence and was referred for fertility preservation by oocyte cryopreservation before chemotherapy and radiotherapy/brachytherapy. Ovarian stimulation was initiated with a gonadotropin antagonist protocol combined with aromatase inhibitors, and oocyte retrieval was performed with a combined laparoscopic and transvaginal approach.ResultsA total of 18 oocytes were retrieved and 10 mature oocytes were cryopreserved. Peritoneal fluid cytology was negative for malignancy. The patient underwent chemotherapy and radiotherapy/brachytherapy and was disease-free after oocyte retrieval.ConclusionThe combined laparoscopic and transvaginal approach for oocyte retrieval emerges as a practical and efficacious method for fertility preservation in cases of cervical adenocarcinoma with vaginal recurrence. Further comprehensive studies are warranted to establish the reproducibility, safety, and long-term outcomes associated with this innovative approach.
Is there any truth in the myth that IVF treatments involve weight gain?
Authors: Saar-Ryss Bozhena , Shilo Michael , Friger Michael , Grin Leonti , Michailov Yulia , Meltcer Simion , Zaks Svetlana , Rabinson Jacob , Lazer Tal , Friedler Shevach 
Published: January 2024

PurposeTo examine body weight change in women undergoing in vitro fertilization and embryo transfer (IVF-ET) using antagonist protocol after up to three treatment cycles.MethodsA prospective cohort study among IVF patients treated between 2018 and 2019. Each patient underwent weight measurement three times during the treatment cycle: before treatment, at the beginning of the hormonal stimulation, and at the completion of the cycle, on the day of the pregnancy test. Data were also analyzed according to the body mass index (BMI) groups for normal weight, overweight, and obese patients. Finally, weight changes were recorded following altogether 519 treatment cycles, 240, 131, and 148 cycles, for normal weight, overweight, and obese patients, respectively.ResultsThe change in the patient's weight was clinically non-significant either during the waiting period or during gonadotropin administration, and overall, during the first, second, or third treatment cycles. The recorded mean total weight change of 0.26 ± 1.85, 0.4 ± 1.81, and 0.17 ± 1.7, after the first, second, or third treatment cycles, represent a change of 0.36%, 0.56%, and 0.23% of their initial weights, respectively. This change of less than 1% of the body weight falls short of the clinically significant weight gain of 5%–7%. Analyzing the data for the various BMI groups, the changes observed in body weight were under 1%, hence with no clinical significance.ConclusionThe findings of the study reject the myth that hormone therapy involves clinically significant weight gain, and this can lower the concerns of many patients who are candidates for treatment of assisted reproductive technology.
Biodiversity and quality of urban green landscape affect mental restorativeness of residents in Multan, Pakistan
Authors: Rehman Zainab , Zubair Muhammad , Hafiz Dalia Osama , Manzoor Syed Amir 
Published: January 2024

IntroductionThe influence of urban green spaces on public health is receiving unprecedented attention. Managing urban greenspaces sustainably requires an understanding of the mechanisms behind the positive effects of urban biodiversity on the wellbeing of residents. Urban parks could improve mental restoration of park users. The restoration potential may be influenced by the biophysical characteristics of the park.MethodsThis study aimed to understand two aspects of urban parks in Multan, Pakistan: (a) How does the perception of biodiversity and the quality of urban parks relate to mental restorativeness of park visitors? (b) What are the determinants of respondents' willingness to pay for the conservation and management of park biodiversity and quality in urban parks? Data were collected from October 2021 to December 2021 through a cross-sectional survey in which 550 park visitors were interviewed from six randomly selected urban parks in Multan. Multiple linear regression analysis, a binary logistic model, and a chi-square test were applied to analyze the data.Results and discussionThe study empirically highlights the positive contribution of park visits to mental restorativeness. Biodiversity and quality were positively correlated with the mental restorativeness of park visitors. Sixty-two percent (62%) of the visitors were reluctant to pay, whereas 38% were ready to pay between Rs. 850/3.7$ and Rs. 1,700/7.4$ each year. Education, occupation, and monthly income significantly positively affected the respondent's WTP attitudes. The study highlights the importance of using urban parks as tools to promote mental restorativeness, combat social stress, and increase urban vegetation cover.
Factors driving FIFA world cup 2022 viewership ratings in mainland China: marketing outlooks for FIFA world cup 2026
Authors: Wang Zongqing , Su Lide , Agudamu  , Gong Tao , Bu Te , Zhang Yang 
Published: January 2024

IntroductionThe FIFA World Cup is not only the most lucrative athletic event globally, but it also functions as a platform for promoting peace owing to FIFA's new vision. Nevertheless, the determinants of TV viewership ratings, especially in the Chinese market, which is a critical revenue stream for FIFA TV broadcasting, are still unsolved. Using a distributional regression, this study aimed to quantify the dynamics of viewership ratings for the FIFA World Cup 2022 in mainland China.MethodsThe CCTV viewership ratings were modeled using 12 covariables related to Chinese TV consumer behavior. Given the data structure, a Logit Normal regression model was chosen to fit the location and dispersion parameters of viewership ratings to explanatory variables.ResultsIn the fitted heteroscedastic model, the viewership ratings dynamics in mainland China were driven by the match kick-off time: μ^=logistic[−4.874+0.043×matchkick-offtime]. In addition, the model captures the factors that influence the variations in viewership ratings: σ^=exp[−14.26–1.346 (if, FIFA World Cup champion = “Yes”) + 0.004 × FIFA world ranking]. Thus, it shows that the FIFA World Cup champions tamp down such variations, leading to a more stable viewing behavior among Chinese consumers.ConclusionsTime- and team-sensitive strategies are proposed to aid in crafting uncertainty-suppressing business decisions for the FIFA World Cup 2026. Ultimately, in the more insecure 2020s, a broader live coverage of the FIFA World Cup would be invaluable for promoting peace.
Serratus anterior plane block for acute pain management after pectus excavatum repair
Authors: Rim Gongmin , Park Hyung Joo , Kang Seungyoun , Jeong Jin Yong , Koo Jungmin , Jang Il-Tae , Bae Saemi 
Published: January 2024

IntroductionConventional postoperative pain management using an intravenous (IV) patient-controlled approach or thoracic epidural analgesia is suboptimal following minimally invasive repair of the pectus excavatum (MIRPE). Recently, cryoanalgesia has gained popularity owing to its superior pain control outcomes compared to those associated with conventional methods. However, because of its invasiveness, additional instrumentation requirement, and limited effect at early postoperative periods, we hypothesized that serratus anterior plane block (SAPB) could be an effective method for post-repair pain management and a possibly superior alternative.MethodsWe conducted a retrospective cohort study of pediatric patients who had undergone MIRPE between March 2022 and August 2023. We compared the efficacy of pain control in three groups among 74 patients: Group N (conventional pain management, n = 24), Group C (cryoanalgesia, n = 24), and Group S (SAPB, n = 26). Group N received IV patient-controlled analgesia (PCA) and a subcutaneous local anesthetic infusion. Group C received bilateral cryoanalgesia on the fourth and seventh intercostal nerves using a cryoprobe at −80°C for 2 min during the operation and IV-PCA postoperatively. Group S received continuous bilateral SAPB with 0.25% ropivacaine and IV-PCA. The pain levels were measured using the visual analog scale (VAS; resting and dynamic), and the total IV rescue analgesic consumption was determined.ResultsThe three groups had similar baseline characteristics. Group S showed significantly less pain throughout the immediate postoperative course, resting VAS score at 3 h (Group N, 7.21 vs. Group C, 5.75 vs. Group S, 3.81; p &lt; 0.001), and prominent less total IV rescue analgesic consumption (Group N, 116.16 mg vs. Group C, 52.75 mg vs. Group S, 16.61 mg; p &lt; 0.001).ConclusionSAPB resulted in better postoperative pain control than that associated with cryoanalgesia and conventional pain management after pectus excavatum repair, As it was effective in the immediate postoperative period, achieving a VAS score of &lt;4 points (moderate pain) at 3 h postoperatively, it may play an important role and replace invasive cryoanalgesia in the management of pain after pectus surgery.
Antimicrobial Activity of Two Different Types of Silver Nanoparticles against Wide Range of Pathogenic Bacteria
Authors: Holubnycha Viktoriia , Husak Yevheniia , Korniienko Viktoriia , Bolshanina Svetlana , Tveresovska Olesia , Myronov Petro , Holubnycha Marharyta , Butsyk Anna , Borén Thomas , Banasiuk Rafal , Ramanavicius Arunas , Pogorielov Maksym 
Published: January 2024

The emergence of antibiotic-resistant bacteria, particularly the most hazardous pathogens, namely Enterococcus faecium, Staphylococcus aureus, Klebsiella pneumoniae, Acinetobacter baumannii, Pseudomonas aeruginosa, and Enterobacter spp. (ESKAPE)-pathogens pose a significant threat to global health. Current antimicrobial therapies, including those targeting biofilms, have shown limited effectiveness against these superbugs. Nanoparticles, specifically silver nanoparticles (AgNPs), have emerged as a promising alternative for combating bacterial infections. In this study, two types of AgNPs with different physic-chemical properties were evaluated for their antimicrobial and antibiofilm activities against clinical ESKAPE strains. Two types of silver nanoparticles were assessed: spherical silver nanoparticles (AgNPs-1) and cubic-shaped silver nanoparticles (AgNPs-2). AgNPs-2, characterized by a cubic shape and higher surface-area-to-volume ratio, exhibited superior antimicrobial activity compared to spherical AgNPs-1. Both types of AgNPs demonstrated the ability to inhibit biofilm formation and disrupt established biofilms, leading to membrane damage and reduced viability of the bacteria. These findings highlight the potential of AgNPs as effective antibacterial agents against ESKAPE pathogens, emphasizing the importance of nanoparticle characteristics in determining their antimicrobial properties. Further research is warranted to explore the underlying mechanisms and optimize nanoparticle-based therapies for the management of infections caused by antibiotic-resistant bacteria.
Soporte familiar en el tratamiento en pacientes con tuberculosis del Hospital Carlos Monge de Juliaca
Authors: Maquera Yuselino , Dávila Cayo Deyssi Mayumi , Zúñiga Vásquez María Emma , Meneses Cariapaza Luz María , Quispe Arapa Victoria Delfina 
Published: January 2024

La tuberculosis (TBC) se convirtió en un problema de salud pública, incrementándose en los últimos años en Perú con 17 mil casos, los factores que afectan son por el diagnóstico y el incumplimiento terapéutico de los pacientes. Un paciente que tenga TBC, requiere de un proceso de servicio hospitalario y se busca una estabilidad física y emocional en aras de una mejora de la calidad de vida, es allí donde la familia juega un papel trascendental en la recuperación del paciente. Objetivo. Determinar la influencia del soporte familiar en el proceso de adaptación al tratamiento en pacientes con tuberculosis. Materiales y métodos. El estudio se encuentra enmarcada dentro del enfoque cuantitativo, de tipo básica, de nivel explicativo, diseño no experimental de corte transaccional y de método hipotético-deductivo. Asimismo, la población fue universal de 40 pacientes, para la recolección de información se utilizó el cuestionario estructurado de tipo escala likert, la cual fue comprobada con el análisis no paramétrico, por medio del chi cuadrado. Resultados. Muestran que el soporte familiar influye significativamente en el proceso de adaptación al tratamiento en pacientes con TBC, ya que se detalla el valor de chi cuadrado y chi tabulada: C (28,619) > T. (5.991) con dos grados de libertad, y con un nivel de significancia de (0.000). Conclusiones. El proceso de soporte familiar influye en los tipos de TBC, siendo el proceso de soporte familiar sustancial para contribuir al tratamiento de los pacientes con TBC, no obstante, influye en los tipos de TBC de los pacientes, es por ello que si no se brinda un buen soporte familiar el paciente deja al lado el tratamiento y la enfermedad avanzaría e incluso cambiaria de tipo.
Terapias de estimulación visual y rendimiento académico de niños de primer año de Educación Básica
Authors: Gallegos Murillo Mónica del Rocío , Ríos Quiñónez María Belén 
Published: January 2024

La terapia visual como tratamiento de estimulación neurofisiológica, permite el desarrollo y mejoría de las habilidades visuales; mismas que inciden de manera directa en el aprendizaje y la lectura. Objetivo. Evaluar el impacto de las terapias de estimulación visual en el rendimiento académico en niños de primer año de básica de una unidad educativa privada en Quito-Ecuador. Materiales y métodos. La investigación fue descriptiva, modalidad de intervención educativa, con alcance explicativo causal y longitudinal. Se trabajó con una muestra intencional conformada por 32 estudiantes de 5 años cumplidos, ambos sexos biológicos, que asistían a clases presenciales, no recibían terapias visuales y, contaban con el consentimiento de los padres. Un profesional especialista en salud visual ejecutó la investigación en tres fases: 1) diagnóstica: medición de las variables como pre–test; 2) aplicación de estrategias: con el despliegue del programa por seis meses para trabajar la estimulación de habilidades visuo-perceptuales y; 3) evaluación del programa tras la intervención de las variables como post - test. Resultados. Tras las terapias, el 97% de la población tuvo un impacto positivo de +60, el porcentaje de agudeza visual inferior se redujo al 0%, incrementó la agudeza visual óptima en OD (43%) y OI (47%), la estereopsis mejoró en un 84% de sujetos, las habilidades visuo-perceptuales fueron aceptables y se mejoró el rendimiento escolar. Conclusiones. Se pudo evidenciar que la estimulación de habilidades visuales a través de terapias específicas, en edades tempranas, es importante y necesaria para evitar problemas futuros en el aprendizaje.