bluuebunny/crossref_metadata_2025_split huggingface dataset:
Genetic evidence for differential functions of figla and nobox in zebrafish ovarian differentiation and folliculogenesis
Authors: Wu Kun , Zhai Yue , Qin Mingming , Zhao Cheng , Ai Nana , He Jianguo , Ge Wei 
Published: November 2023

AbstractFIGLA and NOBOX are important oocyte-specific transcription factors. Both figla-/- and nobox-/- mutants showed all-male phenotype in zebrafish due to increased dominance of the male-promoting pathway. The early diversion towards males in these mutants has precluded analysis of their roles in folliculogenesis. In this study, we attenuated the male-promoting pathway by deleting dmrt1, a key male-promoting gene, in figla-/- and nobox-/- fish, which allows a sufficient display of defects in folliculogenesis. Germ cells in figla-/-;dmrt1-/- double mutant remained in cysts without forming follicles. In contrast, follicles could form well but exhibited deficient growth in nobox-/-;dmrt1-/- double mutants. Follicles in nobox-/-;dmrt1-/- ovary could progress to previtellogenic (PV) stage but failed to enter vitellogenic growth. Such arrest at PV stage suggested a possible deficiency in estrogen signaling. This was supported by lines of evidence in nobox-/-;dmrt1-/-, including reduced expression of ovarian aromatase (cyp19a1a) and level of serum estradiol (E2), regressed genital papilla (female secondary sex characteristics), and more importantly the resumption of vitellogenic growth by E2 treatment. Expression analysis suggested Nobox might regulate cyp19a1a by controlling Gdf9 and/or Bmp15. Our discoveries indicate that Figla is essential for ovarian differentiation and follicle formation whereas Nobox is important for driving subsequent follicle development.
A common pathway for detergent-assisted oligomerization of Aβ42
Authors: Muhammedkutty Fidha Nazreen Kunnath , Prasad Ramesh , Gao Yuan , Sudarshan Tarunya Rao , Robang Alicia S. , Watzlawik Jens O. , Rosenberry Terrone L. , Paravastu Anant K. , Zhou Huan-Xiang 
Published: November 2023

AbstractAmyloid beta (Aβ) aggregation is a slow process without seeding or assisted nucleation. Sodium dodecyl sulfate (SDS) micelles stabilize Aβ42 small oligomers (in the dimer to tetramer range); subsequent SDS removal leads to a 150-kD Aβ42 oligomer. Dodecylphosphorylcholine (DPC) micelles also stabilize an Aβ42 tetramer. Here we investigate the detergent-assisted oligomerization pathway by solid-state NMR spectroscopy and molecular dynamics simulations. SDS- and DPC-induced oligomers have the same structure, implying a common oligomerization pathway. An antiparallel β-sheet formed by the C-terminal region, the only stable structure in SDS and DPC micelles, is directly incorporated into the 150-kD oligomer. Three Gly residues (at positions 33, 37, and 38) create holes that are filled by the SDS and DPC hydrocarbon tails, thereby turning a potentially destabilizing feature into a stabilizing factor. These observations have implications for endogenous Aβ aggregation at cellular interfaces.
Taxonomic identification and temperature stress tolerance mechanisms of Aequorivita marisscotiae sp. nov
Authors: Liu Wenqi , Cong Bailin , Lin Jing , Liu Shenghao , Deng Aifang , Zhao Linlin 
Published: November 2023

AbstractThe deep sea harbours microorganisms with unique life characteristics and activities due to adaptation to particular environmental conditions, but the limited sample collection and pure culture techniques available constrain the study of deep-sea microorganisms. In this study, strain Ant34-E75 was isolated from Antarctic deep-sea sediment samples and showed the highest 16 S rRNA gene sequence similarity (97.18%) with the strainAequorivita viscosa8-1bT. Strain Ant34-E75 is psychrotrophic and can effectively increase the cold tolerance ofChlamydomonas reinhardtii(a model organism). Subsequent transcriptome analysis revealed multiple mechanisms involved in the Ant34-E75 response to temperature stress, and weighted gene co-expression network analysis (WGCNA) showed that the peptidoglycan synthesis pathway was the key component. Overall, this study provides insights into the characteristics of a deep-sea microorganism and elucidates mechanisms of temperature adaptation at the molecular level.
Breakdown of conventional winding number calculation in one-dimensional lattices with interactions beyond nearest neighbors
Authors: Rajabpoor Alisepahi Amir , Sarkar Siddhartha , Sun Kai , Ma Jihong 
Published: November 2023

AbstractTopological insulators hold promises to realize exotic quantum phenomena in electronic, photonic, and phononic systems. Conventionally, topological indices, such as winding numbers, have been used to predict the number of topologically protected domain-wall states (TPDWSs) in topological insulators, a signature of the topological phenomenon called bulk-edge correspondence. Here, we demonstrate theoretically and experimentally that the number of TPDWSs in a mechanical Su-Schrieffer-Heeger (SSH) model can be higher than the winding number depending on the strengths of beyond-nearest-neighbor interactions, revealing the breakdown of the winding number prediction. Alternatively, we resort to the Berry connection to accurately characterize the number and spatial features of TPDWSs in SSH systems, further confirmed by the Jackiw-Rebbi theory proving that the multiple TPDWSs correspond to the bulk Dirac cones. Our findings deepen the understanding of complex network dynamics and offer a generalized paradigm for precise TPDWS prediction in potential applications involving localized vibrations, such as drug delivery and quantum computing.
An expansion planning model for strategic visioning of active distribution network in the presence of local electricity market
Authors: Solat Sajjad , Aminifar Farrokh , Safdarian Amir , Shayanfar Heidarali 
Published: November 2023

AbstractEmergence of different stakeholders with contrary objectives in active distribution network (ADN) requires for a fair network expansion planning that considers all of the contrary objectives. This paper provides an expansion planning model for ADN strategic visioning from electric distribution stakeholders' organization (EDSO) perspective, which takes into account the objectives of all stakeholders. The stakeholders are network owner, active customers (ACs), consumers, and environmental regulatory body (ERB). The proposed model is multistage bi‐level, where the upper‐level minimizes the present value of the total costs imposed to all ADN stakeholders and the lower‐level minimizes the total generation costs within the distribution‐level electricity market. The Karush–Kuhn–Tucker optimality conditions and the linearization techniques are employed through which the model is converted to mixed integer linear programming which can be tackled effectively. The model provides a visionary expansion plan that policymaker must legislate to realize it. Effectiveness of the model in providing a visionary expansion plan considering EDSO's perspective in making cost effective planning decisions per social welfare goals is verified through several case studies on 33‐bus standard test system. According to the simulation results, transition from DSO to EDSO in the presence of low‐capacity ACs improves social welfare by 5%. But this improvement is up to 70% in the presence of high‐capacity ACs.
“Rally around the flag” effects in the Russian–Ukrainian war
Authors: Kizilova Kseniya , Norris Pippa 
Published: November 2023

AbstractFollowing Russia’s full-scale invasion of Ukraine on February 24, 2022, the grounds behind Vladimir Putin’s decision were widely debated. Theories suggest several reasons, including Putin’s nostalgic dream of restoring Soviet imperial glory, Russia’s fears of NATO security threats near their borders. But another explanation may be more prosaic: Putin’s desire to restore his sagging popularity at home by attempting to repeat his 2014 “Crimea” strategy. By annexing territories in Eastern Ukraine, he may have hoped to generate a “rally-around-the flag” effect, boosting his domestic support by appealing to Russian patriotism and nationalism. To examine this thesis, Part I outlines the core concept and what is known in the literature about the size and duration of the rally-around-the flag phenomenon. Part II examines the available time-series survey evidence drawn from a variety of opinion polls in Ukraine, Europe, and Russia focusing on the first 8 months of the war to detect any rally effects associated with Russia’s invasion of Ukraine. Part III examines the evidence of media effects. Part IV adds robustness tests. The conclusion in Part V summarizes the main findings and discusses their broader implications for understanding the roots of the Russian invasion of Ukraine and its consequences.
Social policy in a future of degrowth? Challenges for decommodification, commoning and public support
Authors: Kongshøj Kristian 
Published: November 2023

AbstractAchieving sustainability within planetary boundaries requires radical changes to production and consumption beyond technology- and efficiency-oriented solutions, especially in affluent countries. The literature on degrowth offers visions and policy paths with the explicit aim of ensuring human wellbeing within an economy with a lower resource metabolism. This paper reviews and discusses the academic literature on degrowth with the aim of deriving the main inherent challenges where further research is needed. Proponents of degrowth envisage radical redistribution and decommodification with ‘floors’ and ‘ceilings’ for income and wealth, as well as extensive public service provision. This paper outlines how results from other research support such a policy direction. However, the paper discusses three inherent challenges for such a future with respect to the feasibility and desirability of degrowth policies, as well as their legitimate underpinning in public support. This includes the internal growth dependencies of established social policies, which require changes to financing, output-based management and perhaps even curtailing input (service demand). Secondly, it concerns the role of public welfare provision when degrowth advocates also envisage the proliferation of alternative and informal economies. The paper emphasises that these two challenges invite more work on where public service provision should play a lesser role. Thirdly, the paper covers popular legitimacy. In affluent democracies, popular support needs to expand further beyond the ‘new left’ or the ‘green left’, even if larger shares of the population exhibit some potential for growth-critical stances. At the heart of these challenges is the need for new norms and values with respect to wellbeing, which is envisaged in the literature as a shift from materialist and hedonic towards needs-oriented and eudaimonic conceptions of wellbeing and happiness.
Connecting with fans in the digital age: an exploratory and comparative analysis of social media management in top football clubs
Authors: Romero-Jara Edgar , Solanellas Francesc , Muñoz Joshua , López-Carril Samuel 
Published: November 2023

AbstractIn a globalised society, characterised by increasingly demanding markets and the accelerated growth of the digital approach, sports organisations face the challenge of connecting with fans, generating and maintaining audiences and communicating with stakeholders creatively and efficiently. Social media has become a fundamental tool, with engagement as a critical measurement element. However, despite its popularity and use, many questions about its application, measurement and real potential in the sports sector still need to be answered. Therefore, the main objective of this study is to carry out a descriptive and comparative analysis of the engagement generated through social media posts by elite football clubs in Europe, South America and North America. To this purpose, 19,745 Facebook, Twitter and Instagram posts were analysed, through the design, validation and application of an observation instrument, using content analysis techniques. The findings show evidence of a priority focus on “Marketing” and “Sports” type messages in terms of frequency, with high engagement rates. They were also showing a growing stream of “ESG” type messages, with a low posting frequency but engagement rates similar to “Marketing” and “Sport”. “Institutional” messages remain constant in all football clubs. “Commercial” messages still have growth potential in both regards, frequency and engaging fans, representing an opportunity for digital assets. Also, specific format combinations that generate greater engagement were identified: “text/image” and “text/videos” are the format combinations more used by football clubs on Facebook, Twitter and Instagram; however, resulting in different engagement rates. This study showed evidence of different social media management strategies adopted according to region, obtaining similar engagement rates. This research concludes with theoretical and practical applications that will be of interest to both academics and practitioners to maximise the potential of social media for fan engagement, social initiatives and as a marketing tool.
Listening to the “noise” in the data
Authors: Munro Murray J. 
Published: November 2023

Abstract
The term “noise” is often applied to the seemingly random variability that always appears in human data, and which
is assumed to be of no interest to the researcher. Some of this variability is unavoidably due to measurement tools or the way in
which we use them, and some is due to the unstable nature of human behaviour. In such cases, we may be justified in treating the
variability as irrelevant noise. However, we cannot assume that all inexplicable variation is unimportant. Using
examples from earlier research, I will argue that individual variability is a phenomenon worthy of study in its own right. Not
only can it help us understand the nuances of the learning process, but giving it careful consideration can be a valuable step in
determining how to effectively apply research findings in pedagogy.
Fluidic motion patterns in English and Modern Greek
Authors: Dalpanagioti Thomai 
Published: November 2023

Abstract
This paper investigates conceptual and phraseological patterns from a cross-linguistic perspective. The focus of attention is on the fluidic motion uses of the highly polysemous verbs run and τρέχω ‘run’ in English and Modern Greek respectively. They are manner of motion verbs denoting the typically human, fast movement on ground and they are frequently cited in the literature on motion event encoding; yet, their extended use to denote motion of liquids is mentioned only in passing. The study thus provides a comprehensive description of that part of the semantic network of the two verbs that relates to fluidic motion (literally and figuratively). The contrastive approach taken combines cognitive semantics (Frame Semantics, Conceptual Metaphor and Metonymy Theory) with a phraseological view of language. Convergences and divergences are identified at a conceptual and phraseological level through a twofold corpus-based study involving comparable monolingual analysis and parallel corpus investigation.
Towards an optimised deep brain stimulation using a large-scale computational network and realistic volume conductor model
Authors: Spiliotis Konstantinos , Butenko Konstantin , Starke Jens , van Rienen Ursula , Köhling Rüdiger 
Published: November 2023

Abstract

Objective. Constructing a theoretical framework to improve deep brain stimulation (DBS) based on the neuronal spatiotemporal patterns of the stimulation-affected areas constitutes a primary target. Approach. We develop a large-scale biophysical network, paired with a realistic volume conductor model, to estimate theoretically efficacious stimulation protocols. Based on previously published anatomically defined structural connectivity, a biophysical basal ganglia-thalamo-cortical neuronal network is constructed using Hodgkin–Huxley dynamics. We define a new biomarker describing the thalamic spatiotemporal activity as a ratio of spiking vs. burst firing. The per cent activation of the different pathways is adapted in the simulation to minimise the differences of the biomarker with respect to its value under healthy conditions. Main results. This neuronal network reproduces spatiotemporal patterns that emerge in Parkinson’s disease. Simulations of the fibre per cent activation for the defined biomarker propose desensitisation of pallido-thalamic synaptic efficacy, induced by high-frequency signals, as one possible crucial mechanism for DBS action. Based on this activation, we define both an optimal electrode position and stimulation protocol using pathway activation modelling. Significance. A key advantage of this research is that it combines different approaches, i.e. the spatiotemporal pattern with the electric field and axonal response modelling, to compute the optimal DBS protocol. By correlating the inherent network dynamics with the activation of white matter fibres, we obtain new insights into the DBS therapeutic action.
Response Water Productivity and Sorghum Yield to Deficit Irrigation Under Surface Drip Irrigation System
Authors: Ibrahim Wallada Muammer , Ati Alaa Salih , Majeed Shatha Salim 
Published: November 2023

Abstract
A field experiment was conducted during the spring season of 2022 in a clay loam soil at the experimental station of the College of Agricultural Engineering Sciences, University of Baghdad - Al-Jadriya, in order to study the effect of deficit irrigation on the growth and productivity of Sorghum, using the surface drip irrigation system, the experiment included irrigation treatments with six levels of full irrigation treatment FI100 When 50% of the available water is depleted, it is compensated by the American evaporation basin class A, from which the deficit irrigation treatments 80, 70, 60, 50, and 40% of the complete irrigation were applied, using the RCBD with three replications. The treatments were applied during the included plant growth stages (vegetative growth, flowering and maturity). Crop growth indicators were measured at the end of the season. Sorghum seeds were sown on 3-13-2022 and harvested on 7-15-2022. The results showed that the seasonal water consumption of corn reached its highest value when the full irrigation treatment was 487.24 mm when 50% of the available water was depleted, then it decreased to 413.59, 376.94, 340.29, 303.63, and 266.98 mm for the deficit irrigation treatments (80, 70, 60, 50, and 40%) calculated from the control treatment (FI%100). Irrigation treatment (FI 100%) gave the highest values for average plant height, leaf area, chlorophyll content, total root dry weight and yield. Water consumption amounted to 413.59 and 376.94 mm compared to the full irrigation treatment, while the treatments (60, 50 and 40) % of the full irrigation were superior in that they saved an amount of water at the expense of low crop productivity. The highest water productivity was recorded at two irrigation treatments minus 80 and 70% for the Sorghum bicolorcrop. It amounted to 13.71 and 15.13 kg m3, as the lack of 20 and 30% of the irrigation water did not affect the productivity. It is recommended to irrigate at a rate of 80 and 70% of the total ETa, which indicates the possibility of providing 20 and 30% of the full irrigation needs without affecting the grain yield.
Effects of Nano-Fipronil on Male Rats’ Biochemical, Liver, and Renal Functions
Authors: Al-Janabi Qassim Ammar Ahmood , Hamed Lamees Noori , Ibraheem Aqeel Khaleel 
Published: November 2023

Abstract
Fipronil has been widely employed for crop protection over the past decade because of its low soil stability and insecticidal potency at modest application rates. The present study was designed to investigate the adverse effects of sub-acute exposure to 10 and 20 mg/kg/b. w. of Nano-Fipronil on biochemical blood profile and histological parameters in male rats according to the permissible limits of acceptable daily intake (ADI). The results hematological parameters indicated that Red blood cells (RBCs) and Hemoglobin(H.b) decreased in all treated groups compared with the control. While PLT and white blood cells (WBCs) was significantly increased in all treated groups compared with the control. The toxicity of effects of nano-fipronil pesticides leads to higher levels of liver function parameters (AST, ALT and ALP), kidney function (Blood urea and Creatinin and Uric acid) and Oxidative stress (MDA, GSH and CAT) results demonstrated highly significant differences (P≤0.05) in all groups treated compared with the control.
Evaluation of Genetic Performance and Estimation of some Genetic Parameters in Yield Traits and Components of Four Genetic Structures of Broad Bean Under the Influence of Different Levels of Soil Salinity
Authors: Merhij Mohammed Y. , Al-Khafaji Hamzah Mohsin Kadhim 
Published: November 2023

Abstract
The study was carried out with the aim of evaluating the genetic performance and estimating some genetic parameters in the characteristics of the yield and its components for the four different structures originating from Broad bean (local, Turkish, Spanish and Dutch) under the influence of different levels of soil salinity (2, 6 and 9 ds\m) in the field of the Field Crops Department of the Faculty of Agriculture - Al-Qasim Green University During the growing season of 2022/2023, the experiment was carried out according to the design of the complete random sectors as a factor experiment and with three replicates. The results of the analysis of variance showed significant differences between the four structures of all the traits studied. The Turkish variety significantly outperformed the rest of the other varieties in all the characteristics studied Number of pods (10.12 pods / plant), the number of seeds per pod (4.06 seeds / pod) and the weight of 100 seeds (121.22 g) and the yield of seeds (1.59 tons / ha) and the biological yield (3.19 tons / ha) and protein yield 322.4 kg / ha). pod) weighing 100 seeds (135.02 g), seed yield (2.42 tons/ha), biological yield (4.42 tons/ha) and protein yield 0.507 ton/ha), The results showed that the phenotypic and genetic variations were high for all traits at the level (2 ds/m) but decreased at the salt level (9 ds/m). The percentage of inheritance in the broad sense was very high for all traits and all salt levels, which indicates that the phenotypic variation between the varieties was mostly genetic.