bluuebunny/crossref_metadata_2025_split huggingface dataset:
Twenty years of social media marketing: A systematic review, integrative framework, and future research agenda
Authors: Bartoloni Sara , Ancillai Chiara 
Published: December 2023

AbstractSocial media has been around for 20 years and has profoundly affected the dynamics of interactions between companies and customers. Studies have increasingly focused on how firms effectively use social media in their marketing strategies. However, the literature appears highly fragmented. Scholars have tended to investigate individual facets of social media marketing (SMM) behaviours, adopting a narrow perspective on their antecedents and outcomes. This approach hinders a comprehensive understanding of the overall phenomenon. Against this background, we conducted a systematic literature review (SLR) of 169 articles to develop a causal‐chain framework based on inputs, contingency factors, and outputs to illustrate the interrelationships among different research constructs explored so far. This framework contributes to overcoming the isolated perspectives of firms’ SMM that have characterized the extant knowledge, thus offering clarity and an overarching view of SMM in firms. The findings also provide concrete guidance for future research endeavours in this area.
Medications and cognitive risk in Aboriginal primary care: a cross‐sectional study
Authors: Holdaway Marycarol , Hyde Zoë , Hughson Jo‐anne , Malay Roslyn , Stafford Andrew , Fulford Kate , Radford Kylie , Flicker Leon , Smith Kate , Pond Dimity , Russell Sarah , Atkinson David , Blackberry Irene , LoGiudice Dina 
Published: December 2023

AbstractBackgroundAboriginal and Torres Strait Islander people are ageing with high rates of comorbidity, yet little is known about suboptimal prescribing in this population.AimThe prevalence of potentially suboptimal prescribing and associated risk factors were investigated among older patients attending primary care through Aboriginal Community Controlled Health Services (ACCHSs).MethodsMedical records of 420 systematically selected patients aged ≥50 years attending urban, rural and remote health services were audited. Polypharmacy (≥ 5 prescribed medications), potentially inappropriate medications (PIMs) as per Beers Criteria and anticholinergic burden (ACB) were estimated and associated risk factors were explored with logistic regression.ResultsThe prevalence of polypharmacy, PIMs and ACB score ≥3 was 43%, 18% and 12% respectively. In multivariable logistic regression analyses, polypharmacy was less likely in rural (odds ratio (OR) = 0.43, 95% confidence interval (CI) = 0.24–0.77) compared to urban patients, and more likely in those with heart disease (OR = 2.62, 95% CI = 1.62–4.25), atrial fibrillation (OR = 4.25, 95% CI = 1.08–16.81), hypertension (OR = 2.14, 95% CI = 1.34–3.44), diabetes (OR = 2.72, 95% CI = 1.69–4.39) or depression (OR = 1.91, 95% CI = 1.19–3.06). PIMs were more frequent in females (OR = 1.88, 95% CI = 1.03–3.42) and less frequent in rural (OR = 0.41, 95% CI = 0.19–0.85) and remote (OR = 0.58, 95% CI = 0.29–1.18) patients. Factors associated with PIMs were kidney disease (OR = 2.60, 95% CI = 1.37–4.92), urinary incontinence (OR = 3.00, 95% CI = 1.02–8.83), depression (OR = 2.67, 95% CI = 1.50–4.77), heavy alcohol use (OR = 2.83, 95% CI = 1.39–5.75) and subjective cognitive concerns (OR = 2.69, 95% CI = 1.31–5.52). High ACB was less common in rural (OR = 0.10, 95% CI = 0.03–0.34) and remote (OR = 0.51, 95% CI = 0.25–1.04) patients and more common in those with kidney disease (OR = 3.07, 95% CI = 1.50–6.30) or depression (OR = 3.32, 95% CI = 1.70–6.47).ConclusionAssociations between potentially suboptimal prescribing and depression or cognitive concerns highlight the importance of considering medication review and deprescribing for these patients.
Dimensions of young children's toothbrushing resistance: A qualitative content analysis of discussions on the online parenting forum Mumsnet
Authors: Kettle Jennifer , Marshman Zoe 
Published: December 2023

AbstractBackgroundYoung children's resistant behaviour is a barrier to parental‐supervised brushing. Discussions on online parenting forums offer an insight into parental experiences, behaviour and attitudes. Analysing these discussions also demonstrates how dental advice is represented and potentially resisted.AimTo analyse how young children's toothbrushing resistance is discussed on an online parenting forum.DesignQualitative content analysis of threads on toothbrushing resistance retrieved from the UK parenting forum Mumsnet.ResultsA search was carried out on Mumsnet in April 2022. Overall, 204 relevant threads were identified and analysed. A coding frame was developed. Posters interacted by discussing their experiences of resistance, asking for advice, making suggestions and being both supportive and critical. Thirty‐seven strategies for addressing resistance were identified. Discussions reflected attitudes and concerns relating to young children and toothbrushing resistance, including the idea brushing should be ‘non‐negotiable’. A key issue was the acceptability of physical force or restraint to achieve adequate brushing. Posters invoked dental authority to support their views.ConclusionUnderstanding how toothbrushing resistance is discussed on a parenting forum helps establish what information and advice is shared, and highlights attitudes and concerns that shape how this problem is approached.
A non‐verbal teaching behaviour analysis for improving pointing out gestures: The case of asynchronous video lecture analysis using deep learning
Authors: Yoon Ho Young , Kang Seokmin , Kim Sungyeun 
Published: December 2023

AbstractBackgroundResearch into enhancing the effectiveness of information delivery in asynchronous video lectures remains sparse. This study analyzes the nonverbal teaching behaviours in asynchronous online videos, drawing comparisons between pre‐service and in‐service teachers (ITs).ObjectivesThis research primarily aims to juxtapose the nonverbal teaching behaviours, such as arm extensions and body orientation, utilized by pre‐service teachers (PTs) and ITs within asynchronous online videos.MethodsAsynchronous video lectures from four pre‐service and four ITs across four diverse subject topics were scrutinized. Leveraging deep learning technology, teachers' poses during their instruction towards a video camera were quantified, with a particular focus on arm stretch range and body orientation in relation to the subject being taught.ResultsThe findings revealed that PTs were deficient in effectively employing pointing gestures. Their arm stretches and body orientation towards the board were not differentiated across subjects. Conversely, ITs demonstrated subject‐specific variations in their arm extension and body orientation, signalling their effective strategies for knowledge dissemination.Conclusions and DiscussionThis study emphasizes the importance of assessing nonverbal teaching behaviours in the development of effective instructional training. It accentuates the need for nonverbal communication and subject‐specific teaching strategy training in PTs. Future investigations could broaden their scope to include larger sample sizes and expanded subject areas to discern more comprehensive trends in nonverbal teaching behaviours.
circELP2 reverse‐splicing biogenesis and function as a pro‐fibrogenic factor by targeting mitochondrial quality control pathway
Authors: Zhang Songzi , Tu Diwei , Liu Weili , Li Ruiqiong , Jiang Mengqi , Yuan Xinglong , Luan Jianlin , Li Hongbo , Lv Changjun , Song Xiaodong 
Published: December 2023

AbstractIdiopathic pulmonary fibrosis (IPF) is considered as a chronic, fibrosing interstitial pneumonia with unknown mechanism. The present work aimed to explore the function, biogenesis and regulatory mechanism of circELP2 in pulmonary fibrosis and evaluate the value of blocking circELP2‐medicated signal pathway for IPF treatment. The results showed that heterogeneous nuclear ribonucleoprotein L initiated reverse splicing of circELP2 resulting in the increase of circELP2 generation. The biogenetic circELP2 activated the abnormal proliferation and migration of fibroblast and extracellular matrix deposition to promote pulmonary fibrogenesis. Mechanistic studies demonstrated that cytoplasmic circELP2 sponged miR‐630 to increase transcriptional co‐activators Yes‐associated protein 1 (YAP1) and transcriptional co‐activator with PDZ‐binding motif (TAZ). Then, YAP1/TAZ bound to the promoter regions of their target genes, such as mTOR, Raptor and mLST8, which in turn activated or inhibited the genes expression in mitochondrial quality control pathway. Finally, the overexpressed circELP2 and miR‐630 mimic were packaged into adenovirus vector for spraying into the mice lung to evaluate therapeutic effect of blocking circELP2‐miR‐630‐YAP1/TAZ‐mitochondrial quality control pathway in vivo. In conclusion, blocking circELP2‐medicated pathway can alleviate pulmonary fibrosis, and circELP2 may be a potential target to treat lung fibrosis.
Exposure to prenatal infection and the development of internalizing and externalizing problems in children: a longitudinal population‐based study
Authors: Suleri Anna , Rommel Anna‐Sophie , Neumann Alexander , Luo Mannan , Hillegers Manon , de Witte Lotje , Bergink Veerle , Cecil Charlotte A. M. 
Published: December 2023

BackgroundA large body of work has reported a link between prenatal exposure to infection and increased psychiatric risk in offspring. However, studies to date have focused primarily on exposure to severe prenatal infections and/or individual psychiatric diagnoses in clinical samples, typically measured at single time points, and without accounting for important genetic and environmental confounders. In this study, we investigated whether exposure to common infections during pregnancy is prospectively associated with repeatedly assessed child psychiatric symptoms in a large population‐based study.MethodsOur study was embedded in a prospective pregnancy cohort (Generation R; n = 3,598 mother–child dyads). We constructed a comprehensive prenatal infection score comprising common infections for each trimester of pregnancy. Child total, internalizing, and externalizing problems were assessed repeatedly using the parent‐rated Child Behavioral Checklist (average age: 1.5, 3, 6, 10, and 14 years). Linear mixed‐effects models were run adjusting for a range of confounders, including child polygenic scores for psychopathology, maternal chronic illness, birth complications, and infections during childhood. We also investigated trimester‐specific effects and child sex as a potential moderator.ResultsPrenatal exposure to infections was associated with higher child total, internalizing, and externalizing problems, showing temporally persistent effects, even after adjusting for important genetic and environmental confounders. We found no evidence that prenatal infections were associated with changes in child psychiatric symptoms over time. Moreover, in our trimester‐specific analysis, we did not find evidence of significant timing effects of prenatal infection on child psychiatric symptoms. No interactions with child sex were identified.ConclusionsOur research adds to evidence that common prenatal infections may be a risk factor for psychiatric symptoms in children. We also extend previous findings by showing that these associations are present early on, and that rather than changing over time, they persist into adolescence. However, unmeasured confounding may still explain in part these associations. In the future, employing more advanced causal inference designs will be crucial to establishing the degree to which these effects are causal.
Consistency of convolutional neural networks in dermoscopic melanoma recognition: A prospective real‐world study about the pitfalls of augmented intelligence
Authors: Goessinger E. V. , Cerminara S. E. , Mueller A. M. , Gottfrois P. , Huber S. , Amaral M. , Wenz F. , Kostner L. , Weiss L. , Kunz M. , Maul J.‐T. , Wespi S. , Broman E. , Kaufmann S. , Patpanathapillai V. , Treyer I. , Navarini A. A. , Maul L. V. 
Published: December 2023

AbstractBackgroundDeep‐learning convolutional neural networks (CNNs) have outperformed even experienced dermatologists in dermoscopic melanoma detection under controlled conditions. It remains unexplored how real‐world dermoscopic image transformations affect CNN robustness.ObjectivesTo investigate the consistency of melanoma risk assessment by two commercially available CNNs to help formulate recommendations for current clinical use.MethodsA comparative cohort study was conducted from January to July 2022 at the Department of Dermatology, University Hospital Basel. Five dermoscopic images of 116 different lesions on the torso of 66 patients were captured consecutively by the same operator without deliberate rotation. Classification was performed by two CNNs (CNN‐1/CNN‐2). Lesions were divided into four subgroups based on their initial risk scoring and clinical dignity assessment. Reliability was assessed by variation and intraclass correlation coefficients. Excisions were performed for melanoma suspicion or two consecutively elevated CNN risk scores, and benign lesions were confirmed by expert consensus (n = 3).Results117 repeated image series of 116 melanocytic lesions (2 melanomas, 16 dysplastic naevi, 29 naevi, 1 solar lentigo, 1 suspicious and 67 benign) were classified. CNN‐1 demonstrated superior measurement repeatability for clinically benign lesions with an initial malignant risk score (mean variation coefficient (mvc): CNN‐1: 49.5(±34.3)%; CNN‐2: 71.4(±22.5)%; p = 0.03), while CNN‐2 outperformed for clinically benign lesions with benign scoring (mvc: CNN‐1: 49.7(±22.7)%; CNN‐2: 23.8(±29.3)%; p = 0.002). Both systems exhibited lowest score consistency for lesions with an initial malignant risk score and benign assessment. In this context, averaging three initial risk scores achieved highest sensitivity of dignity assessment (CNN‐1: 94%; CNN‐2: 89%). Intraclass correlation coefficients indicated ‘moderate’‐to‐‘good’ reliability for both systems (CNN‐1: 0.80, 95% CI:0.71–0.87, p < 0.001; CNN‐2: 0.67, 95% CI:0.55–0.77, p < 0.001).ConclusionsPotential user‐induced image changes can significantly influence CNN classification. For clinical application, we recommend using the average of three initial risk scores. Furthermore, we advocate for CNN robustness optimization by cross‐validation with repeated image sets.Trial RegistrationClinicalTrials.gov (NCT04605822).
Parasitism success of Microplitis manilae (Hymenoptera: Braconidae) on different diet‐fed Spodoptera frugiperda (Lepidoptera: Noctuidae) larvae
Authors: Tian Shuang , Di Xue‐Yuan , Yan Bin , Ren Peng , Wu Hui‐Zi , Yang Mao‐Fa 
Published: December 2023

AbstractEfficient rearing is necessary for the successful biological control of pests. The braconid wasp, Microplitis manilae, is a natural solitary parasitoid of larval Spodoptera frugiperda. However, the effect of the host diet on the parasitism success of M. manilae on S. frugiperda larvae remains unclear. Here, we determined the parasitism rate, oviposition, eclosion rate, developmental period and offspring sex ratio of M. manilae parasitizing S. frugiperda fed with fresh corn leaves or an artificial diet. M. manilae parasitizing the corn leaf‐fed S. frugiperda larvae exhibited a significantly higher parasitism rate (40%), oviposition (62.50 eggs/female) and eclosion rate (81.38%) than the wasp parasitizing the artificial diet‐fed S. frugiperda larvae (22%, 38.33 eggs/female, and 58.73%, respectively). Furthermore, M. manilae parasitizing the corn leaf‐fed S. frugiperda larvae exhibited a significantly shorter developmental period (16.35 days) and lower sex ratio (1.17) than the wasp parasitizing the artificial diet‐fed S. frugiperda larvae (18.00 and 2.15 days, respectively). Overall, M. manilae exhibited better parasitic success on corn leaf‐fed S. frugiperda larvae than on artificial diet‐fed S. frugiperda larvae. Therefore, using fresh corn leaf‐fed S. frugiperda is the most suitable strategy for mass‐rearing M. manilae for pest biocontrol. Our findings suggest M. manilae as an effective biocontrol candidate for controlling S. frugiperda in corn fields.
In‐depth study of Wood's lamp examination combined with reflective confocal laser scanning microscopy for the guidance of vitiligo staging and treatment
Authors: Hou Yongqing , Wei Zijia , Jiang Qian , Chen Hongying , Chen Liuqing , Wu Jiyuan 
Published: December 2023

AbstractBackgroundBoth Wood's lamp and reflective confidential laser scanning microcopy are helpful for the diagnosis and treatment of vitiligo. However, there is few research that contains large samples and consistent observations.AimsTo analyze the characteristics of Wood's lamp images and reflectance confocal microscopy (RCM) images of vitiligo lesions and to evaluate their significance in vitiligo staging.MethodsWe analyzed the characteristics of RCM images, Wood's lamp images, the vitiligo disease activity (VIDA) score, and clinical features to guide vitiligo staging and treatment.ResultsThe expert consensus based on the clinical features, VIDA score, Wood's lamp findings, and isomorphic response was consistent with the Wood's lamp findings (χ2 = 3.63, p > 0.05) and RCM findings (χ2 = 3.60, p > 0.05) in diagnosing vitiligo and assessing the disease stage. There was a correlation between the three lesion grades based on the Wood's lamp findings and the stage of vitiligo (p < 0.01). Lesions that appeared porcelain white under the Wood's lamp were in the slowly progressive stage; lesions that appeared gray‐white or trichromatic under the Wood's lamp were in the rapidly progressive stage; lesions with clear borders under the Wood's lamp needed further analysis by RCM for the stage to be determined; lesions with blurred borders under the Wood's lamp were in the rapidly progressive stage; lesions that were visible under the naked eye and under the Wood's lamp were in the rapidly progressive stage.ConclusionThe study demonstrates a reliable correlation between the findings of RCM (a sophisticated expensive tool) and Wood's lamp examination (a simple, readily available, inexpensive tool) in the assessment of the disease activity of vitiligo lesions.
Board‐level governance and corporate social responsibility: A meta‐analytic review
Authors: Hussain Nazim , Khan Sana Akbar , Nguyen Duc Khuong , Stocchetti Andrea , Corbet Shaen 
Published: December 2023

AbstractBoard‐level corporate governance (CG) is an effective route to developing sustained ethical behavior, helping firms to meet emerging accountability challenges and international expectations of corporate performance. In recent times, researchers have extensively studied the relationships between various board‐level governance mechanisms and corporate social responsibility (CSR) outcomes; however, results vary substantially. This study addresses the existing heterogeneity in the literature by systematically synthesizing 89 empirical studies on the board governance‐CSR nexus using meta‐analyses using random effect models. Results indicate that most governance mechanisms are strongly associated with CSR disclosure. On the contrary, only a few governance mechanisms are found to be significantly associated with CSR performance, suggesting that not all governance mechanisms are equally effective for performance and disclosure. However, board size and the presence of CSR committee on board are the closest predictors of both CSR outcomes. Additionally, our analysis of the moderating effect of study characteristics shows that coverage period, geographical setting, and measurement of CSR generate variability in existing findings. Our synthesis of the extant literature identifies a theoretical gap, clarifies the board CG‐CSR relationship, and proposes future research directions and guidelines within the field.
Monopsony Power and Upstream Innovation*
Authors: Parra Álvaro , Marshall Guillermo 
Published: December 2023

AbstractHow does a monopsonist incentivize its supplier to innovate? By decreasing the short‐run profit of the supplier, the monopsonist can increase the supplier's incentive to invest in R&D by lessening the supplier's Arrow's replacement effect. The monopsonist engages in this practice despite a distortion in its trade volume with the supplier that causes inefficiency. We discuss implications for the boundaries of the firm.
Distribution of rapid HCV antibody self‐test kits via needle/syringe dispensing machines: Implementation and evaluation of the Vend‐C pilot study in Melbourne, Australia
Authors: O'Keefe Daniel , Jacka David , Douglass Caitlin , Gunn Jack , Stoove Mark , Crawford Sione , Bryant Mellissa , Higgs Peter , Dietze Paul , Hellard Margaret 
Published: December 2023

AbstractRecent guidance from the World Health Organization strongly recommended hepatitis C virus (HCV) self‐testing. We implemented the Vend‐C pilot study to explore the effectiveness and feasibility of distributing rapid HCV antibody self‐test kits to people who inject drugs via needle/syringe dispensing machines (SDMs). Over a 51‐day study period between August and September 2022, we distributed HCV antibody self‐test kits via two SDMs. During the study period, 63 self‐test kits were dispensed, averaging 1.2 self‐test kits per day. Our access methods for evaluation questionnaires failed to attract participants (n = 4). We implemented the Vend‐C pilot study in direct response to recent WHO recommendations. While self‐test kits were effectively distributed from the two SDMs, our evaluation methodology failed. Consequently, we cannot determine the success of linkage to care. Even so, with HCV treatment numbers dropping in Australia, innovative engagement solutions are needed, and considering the number of self‐test kits provided in our pilot, the model could have an important future place in HCV elimination efforts.
The impact of hepatitis B and C positive serologies on the outcomes of non‐hepatic solid organ transplantation in the United States
Authors: Alqahtani Saleh A. , Stepanova Maria , Al Shabeeb Reem , Eberly Kathrine Luz , Ong Janus , Younossi Zobair M. 
Published: December 2023

AbstractChronic viral hepatitis B (HBV) and C (HCV) infection could negatively affect outcomes of non‐hepatic solid organ transplantations due to the risk of viral reactivation in the presence of immunosuppression. This study aimed to determine post‐transplant outcomes in patients with HBV or HCV positivity receiving non‐hepatic solid‐state organ transplant. Data was collected from the Scientific Registry of Transplant Recipients (SRTR) 2006–2021 for patients (≥18) who received a lung, heart, or kidney single organ transplant in the U.S. Hepatitis C positivity (HCV+) was determined as positive HCV Ab and hepatitis B positivity (HBV+) as positive HBsAg. We included N = 30,872 lung, N = 36,990 heart and N = 280,162 kidney transplant recipients. The prevalence of HBV+ was 1.3% in lung, 1.5% in heart and 1.7% in kidney patients, HCV+ was 2.2%, 2.2% and 5.0%, respectively. Post‐transplant survival of patients with vs. without HBV+ was similar in all solid organ transplants (all p > .05). Similarly, there was no difference in post‐transplant survival between lung transplant recipients with vs. without anti‐HCV (all p > .05). Heart transplant recipients with HCV+ had higher crude post‐transplant mortality (all p < .01). Similarly, there was higher post‐transplant mortality in kidney transplant recipients with HCV+ (1‐year: 6% vs. 3%; 5‐year: 21% vs. 13%; 10‐year: 47% vs. 31%; all p < .0001). In multivariate analysis controlling for confounders, only the association of HCV+ with higher post‐kidney transplant mortality remained significant: adjusted hazard ratio (aHR) (95% CI) = 1.16 (1.12–1.20), p < .0001. There was no association of viral hepatitis seropositivity with the risk of graft failure in all groups (p > .05). In most cases, the presence of HBV or HCV serologies is not associated with adverse post‐transplant outcomes in non‐hepatic solid organ transplants. However, kidney transplant recipients who are positive for HCV serology have an increased risk for post‐transplant mortality.