bluuebunny/crossref_metadata_2025_split huggingface dataset:
Small bowel adenocarcinomas with favorable prognoses by radical resection and adjuvant chemotherapy: a case series of five cases
Authors: Nishioka Yuri , Matsumoto Yasunori , Imanishi Shunsuke , Endo Satoshi , Toyozumi Takeshi , Kurata Yoshihiro , Sasaki Takuma , Ohira Gaku , Hayano Koichi , Matsubara Hisahiro 
Published: October 2023

Abstract
Background
Small bowel cancer is very rare, accounting for less than 5% of all gastrointestinal cancers, and small bowel adenocarcinoma accounts for approximately 40% of all small bowel cancers. Small bowel adenocarcinoma is often found in advanced stages, with only 40–65% of cases being curatively resectable. The prognosis is poor, with a 5-year survival rate of 14–33% for all patients and 40–60% for those who are curatively resectable. In Japan, practice guidelines for duodenal cancer were instituted in 2021. However, evidence-based standard treatments have not been established for jejunal and ileal cancers. In particular, chemotherapeutic options are limited, and there are only a few reports on multidisciplinary treatments, including adjuvant chemotherapy.

Case presentation
We report five cases of jejunal or ileal lesions that were treated with adjuvant chemotherapy after radical resection. Three patients were male and two were female, with a median age of 67 years. Tumor localization was observed in the jejunum in all cases. Clinical staging was as follows: stage IIIA in two cases and stage IIIB in three cases. Laparotomy was then performed in all cases, employing partial resection with lymph node dissection. Pathological staging in all cases was as follows: stage IIB in two cases, stage IIIA in one case, and stage IIIB in two cases. In all cases, the regimen for adjuvant chemotherapy was selected based on the colorectal cancer guidelines. No serious complications arose from adjuvant therapy; however, adverse events occurred in patients receiving multi-agent chemotherapy. No recurrence was observed in any of the cases, and all the patients survived, with a median survival time of 32 months. As a representative case, we present a case of adjuvant chemotherapy for jejunal adenocarcinoma staged as pT3N2M0, pStage IIIB, with no recurrence at 32 months postoperatively.

Conclusions
In general, favorable outcomes were achieved with adjuvant therapy applied in accordance with the criteria for colorectal cancer. These favorable outcomes suggest that it is necessary to identify the risk factors and indications for adjuvant therapy, specifically for small bowel adenocarcinoma.
The effects of an individualized smartphone-based exercise program on self-defined motor tasks in Parkinson’s disease: a long-term feasibility study
Authors: Lützow Lisa , Teckenburg Isabelle , Koch Veronika , Marxreiter Franz , Jukic Jelena , Stallforth Sabine , Regensburger Martin , Winkler Jürgen , Klucken Jochen , Gaßner Heiko 
Published: October 2023

Abstract
Background
Exercise therapy is considered effective for the treatment of motor impairment in patients with Parkinson’s disease (PD). During the COVID-19 pandemic, training sessions were cancelled and the implementation of telerehabilitation concepts became a promising solution. The aim of this controlled interventional feasibility study was to evaluate the long-term acceptance and to explore initial effectiveness of a digital, home-based, high-frequency exercise program for PD patients. Training effects were assessed using patient-reported outcome measures combined with sensor-based and clinical scores.

Methods
16 PD patients (smartphone group, SG) completed a home-based, individualized training program over 6–8 months using a smartphone app, remotely supervised by a therapist, and tailored to the patient’s motor impairments and capacity. A control group (CG, n = 16) received medical treatment without participating in digital exercise training. The usability of the app was validated using System Usability Scale (SUS) and User Version of the Mobile Application Rating Scale (uMARS). Outcome measures included among others Unified Parkinson Disease Rating Scale, part III (UPDRS-III), sensor-based gait parameters derived from standardized gait tests, Parkinson’s Disease Questionnaire (PDQ-39), and patient-defined motor activities of daily life (M-ADL).

Results
Exercise frequency of 74.5% demonstrated high adherence in this cohort. The application obtained 84% in SUS and more than 3.5/5 points in each subcategory of uMARS, indicating excellent usability. The individually assessed additional benefit showed at least 6 out of 10 points (Mean = 8.2 ± 1.3). From a clinical perspective, patient-defined M-ADL improved for 10 out of 16 patients by 15.5% after the training period. The results of the UPDRS-III remained stable in the SG while worsening in the CG by 3.1 points (24%). The PDQ-39 score worsened over 6–8 months by 83% (SG) and 59% (CG) but the subsection mobility showed a smaller decline in the SG (3%) compared to the CG (77%) without reaching significance level for all outcomes. Sensor-based gait parameters remained constant in both groups.

Conclusions
Long-term training over 6–8 months with the app is considered feasible and acceptable, representing a cost-effective, individualized approach to complement dopaminergic treatment. This study indicates that personalized, digital, high-frequency training leads to benefits in motor sections of ADL and Quality of Life.
Translation, validation and psychometric properties of the Dutch version of the Inflammatory Bowel Disease-Fatigue (IBD-F) self-assessment scale
Authors: Stoker Annemay M. H. , Gruters Angélique , Loon Mirjam C. M. van der Ende-van , Postulart Debby , Czuber-Dochan Wladyslawa , Gilissen Lennard P. L. 
Published: October 2023

Abstract
Background
In patients with inflammatory bowel disease (IBD), a symptom with major impact on health-related quality of life is fatigue. To assess fatigue and conduct research regarding fatigue in IBD patients, a validated disease specific assessment tool is required. The aim of this study was to translate the Inflammatory Bowel Disease Fatigue patient self-assessment scale (IBD-F) into Dutch and to validate this translated scale in a Dutch IBD population.

Methods
The study comprised three phases. In phase 1, the original IBD-F was translated into Dutch. Phase 2 comprised a pilot-test of the pre-final Dutch IBD-F to assess content validity by applying a semi-structured interview design. In phase 3, construct validity, internal consistency and test-retest reliability were assessed using a cross-sectional design.

Results
Phase 1 resulted in the pre-final version of the Dutch IBD-F. After five semi-structured interviews with IBD patients in phase 2, minor adjustments were made which resulted in the final version of the Dutch IBD-F. Evaluation of this final version in 133 IBD patients showed adequate psychometric properties: good convergent validity with the Multidimensional Fatigue Inventory subscales (Spearman’s r 0.57–0.86) and excellent internal consistency (Cronbach’s alpha 0.94 for Section I and 0.97 for Section II). Test-retest reliability in 102 patients was shown to be good (Section I ICC 0.85 (95% CI 0.79–0.90) and Section II ICC 0.88 (95% CI 0.83–0.92)).

Conclusions
The thorough translation process resulted in a comprehensible, valid and reliable version of the Dutch IBD-F. Convergent validity with the MFI-20 appeared to be good. This study found excellent internal consistency and good test-retest reliability.
Multiple sclerosis and fecundity: a study of anti-mullerian hormone level in Egyptian patients
Authors: Zaki Maha Atef , Ramzy Gihan , Ali Samah , Sharaf Sahar Abdelatty , Hegazy Mohamed I. , Mostafa Emad , Fawzy Ibrahim , El-Ghoneimy Lobna 
Published: October 2023

Abstract
Background
Multiple sclerosis (MS) is a neurological disease that affects people aged 20–40 years on average. It classically affects young females of reproductive age. The prevalence of MS for females to males has increased markedly in recent years (from 2.3 to 3.5:1). Females with MS seem to use infertility treatments more frequently and fecundity could be affected years before making an MS diagnosis. The anti-Müllerian hormone (AMH) level is the strongest marker of ovarian reserve. Although recent studies suggest that patients with MS have lower ovarian reserve, there is no definite data to conclude that females with MS suffer from impaired fertility. This study aimed to investigate fertility and fecundity among female patients with MS by assessing AMH level. This study included 100 patients with MS and 60 healthy controls (HC). Both groups were assessed for AMH levels, activities of daily living (ADL) were assessed using the Kurtzke Expanded Disability Status Scale (EDSS) and the reproductive history of both groups was assessed via a self-administered questionnaire.

Results
AMH levels among the HCs (0.34–2 ng/ml with a mean of 1.03 ± 0.41 ng/ml) were significantly higher than in patients with MS (0.15–2 ng/ml with a mean of 0.68 ± 0.31 ng/ml). The use of disease-modifying therapies (DMT) was the only predictor of below normal AMH among patients, but there was no significant correlation with age, duration of disease or type of DMT.

Conclusions
Levels of AMH were significantly lower in MS patients than in healthy controls.
A comparative study between surgical cut down and percutaneous closure devices in management of large bore arterial access
Authors: Mousa Mohamed Ahmed , Zahwy Sherif Samir El , Tamara Ahmed Fathy , Samir Wafed , Tantawy Mahmoud Ahmed 
Published: October 2023

Abstract
Background
Compared to conventional open surgery, minimally invasive catheter-based procedures have less post procedural complications. Transcatheter aortic valve implantation (TAVI) and endovascular aneurysm repair (EVAR) require large bore arterial access. Optimal site management of large bore arterial access is pivotal to reduce the hospital-acquired complications associated with large bore arterial access. We wanted to compare surgical cutdown versus percutaneous closure devices in site management of large bore arterial access.

Methods
Participants planned for TAVI or EVAR with large bore arterial access more than 10 French were included, while participants with history of bypass surgery, malignancies, thrombophilia, or sepsis were excluded. A consecutive sample of 100 participants (mean age 74.66 ± 2.65 years, 61% males) was selected, underwent TAVI or EVAR with surgical cutdown (group 1) versus TAVI or EVAR with Proglide™ percutaneous closure device (group 2).

Results
The incidence rate of hematoma was significantly lower in group 2 versus group 1 (p = 0.014), the mean procedure time (minutes) and the median hospital stay (days) were significantly higher in group 1 versus group 2 (t(98) =  − 2.631, p = 0.01, and U = 2.403, p = 0.018, respectively), and the c-reactive protein pre-procedure and the c-reactive protein post-procedure were significantly lower in group 2 versus group 1 (U = -2.969, p = 0.003, and U = -2.674, p = 0.007, respectively).

Conclusions
Our study showed a lower incidence rate of large bore arterial access complications as hematoma, a shorter procedure time, and a shorter hospital stay with percutaneous closure devices compared to surgical cutdown.
The role of miRNA20a and miRNA320 in Iraqi patients with COVID-19: a case–control study
Authors: Abed Reema Mohammed , Abdulmalek Hadeel Waleed , Yaaqoob Laith Ahmad 
Published: October 2023

Abstract
Background
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), the etiological agent responsible for the onset of coronavirus disease 2019 (COVID-19), elicits a wide range of clinical manifestations, spanning from asymptomatic infection to the development of severe and potentially fatal diseases. The involvement of host microribonucleic acids (microRNAs) in the cytokine storm induced by SARS-CoV-2 infection has been observed, leading to their identification as potential biomarkers for COVID-19. Consequently, the objective of this study was to examine the expression of miRNA-20a and miRNA-320 in 145 COVID-19 patients and 145 healthy controls using quantitative real-time polymerase chain reaction (qRT-PCR).

Results
The results indicated a significant increase in miRNA-20a expression with fold change (10.65; P ≤ 0.0001), while decreased expression of miRNA-320 was found with fold change (0.48; P ≤ 0.0001) in COVID-19 patients. The specificity and sensitivity of miRNAs in COVID-19 patients were assessed using receiver operating characteristic (ROC) analysis.

Conclusion
miRNA-20a and miRNA-320 may serve as potential COVID-19 diagnostic biomarkers with high sensitivity and specificity.
Weathering the Occupation
Authors: Bhan Mona 
Published: October 2023

Abstract
This article examines how weather became an important element of India’s imperial project particularly after 2019, while its everyday forecast and management, as well as its seeming predictability, offered the Indian state an illusion of control in Kashmir’s uncertain political terrain. Against this backdrop, the article foregrounds how weathering the occupation offers a critical analytic to track the eco-logics of the Indian occupation in Kashmir and to consider how Kashmiris rely on the potency of differently constituted “earth beings” to envision alternative political, ecological, and geographic futures. As Kashmir’s climate vulnerabilities intensify because of India’s occupational and settler-colonial regimes, how can weather intrusions unravel geopolitics and contest the fiction of national cartographies? In other words, how might centering weather, rather than nation or borders, help us reenvision Kashmir’s futures beyond the confines of Indian statehood?
From Islamists to Religious Patriots
Authors: Al-Ali Nadje , Kurt Mashuq 
Published: October 2023

AbstractThis article explores the complex and intersectional identities and positionalities of Kurdish Islamist women activists in Turkey in the context of heightened violence and tensions linked to the ongoing Turkish-Kurdish conflict. While both female Islamist activists and Kurdish activists in Turkey and the wider region have been subject to in-depth research over the past decade, Kurdish Islamist women have largely been overlooked in the literature. The article focuses on the complex relationship between ethnicity and religion in understanding Kurdish Islamist women’s mobilization, political views, perceptions of gender norms and relations, and self-ascribed identities. Based on original empirical research carried out in southeastern Turkey in 2015 and 2018, the article engages with the relevant literature on Islamist women’s mobilization, particularly in relation to Turkey, to complicate discourses of empowerment and critiques of liberal notions of agency while also challenging prevailing depictions of Kurdish women’s mobilization. It pays attention both to the intersecting power configurations enabling and challenging Kurdish Islamist women’s everyday lives and political engagement, and to changing political economy locally, nationally, and transnationally.
“My Body, My Decision!”
Authors: Saluk Seda 
Published: October 2023

AbstractThis article examines the discourses and strategies used by reproductive rights activists in Turkey to counter the state’s antiabortion policies. Drawing on a critical genealogical analysis, the article first traces the concept of “bodily autonomy” in feminist mobilizations against sexual and ethnoracial violence from the 1980s to the first decade of the 2000s. It then focuses on the slogan of the 2012 abortion rights mobilizations, “My body, my decision!,” which relies on bodily autonomy as the central trope of claim making. The article argues that the slogan is limited, not because it draws on a liberal, individualistic framework but because it represents the bodily autonomy of the white reproductive subject, assuming that it is an ethnoracially unmarked, universal subject. In doing so, the article demonstrates how feminist strategies that build on bodily autonomy obscure the state’s stratified reproductive policies, which have historically promoted a Turkish majority at the expense of non-Turkish lives.
Determination of water balance maintenance in Orcinus orca and Tursiops truncatus using oxygen isotopes
Authors: Séon Nicolas , Brasseur Isabelle , Scala Christopher , Tacail Théo , Catteau Sidonie , Fourel François , Vincent Peggy , Lécuyer Christophe , Suan Guillaume , Charbonnier Sylvain , Vinçon-Laugier Arnauld , Amiot Romain 
Published: October 2023

ABSTRACT
The secondary adaptation of Cetacea to a fully marine lifestyle raises the question of their ability to maintain their water balance in a hyperosmotic environment. Cetacea have access to four potential sources of water: surrounding salt oceanic water, dietary free water, metabolic water and inhaled water vapour to a lesser degree. Here, we measured the 18O/16O oxygen isotope ratio of blood plasma from 13 specimens belonging to two species of Cetacea raised under human care (four killer whales Orcinus orca, nine common bottlenose dolphins Tursiops truncatus) to investigate and quantify the contribution of preformed water (dietary free water, surrounding salt oceanic water) and metabolic water to Cetacea body water using a box-modelling approach. The oxygen isotope composition of Cetacea blood plasma indicates that dietary free water and metabolic water contribute to more than 90% of the total water input in weight for cetaceans, with the remaining 10% consisting of inhaled water vapour and surrounding water accidentally ingested or absorbed through the skin. Moreover, the contribution of metabolic water appears to be more important in organisms with a more lipid-rich diet. Beyond these physiological and conservation biology implications, this study opens up questions that need to be addressed, such as the applicability of the oxygen isotope composition of cetacean body fluids and skeletal elements as an environmental proxy of the oxygen isotope composition of present and past marine waters.
Is There a VA Advantage? Evidence from Dually Eligible Veterans
Authors: Chan David C. , Card David , Taylor Lowell 
Published: October 2023

We study public versus private provision of health care for veterans aged 65 and older who may receive care provided by the US Department of Veterans Affairs (VA) and in private hospitals financed by Medicare. Utilizing the ambulance design of Doyle et al. (2015), we find that the VA reduces 28-day mortality by 46 percent (4.5 per centage points) and that these survival gains are persistent. The VA also reduces 28-day spending by 21 percent and delivers strikingly different reported services relative to private hospitals. We find suggestive evidence of complementarities between continuity of care, health IT, and integrated care. (JEL H51, I11, I12, I18, J14)
Adaptación y validación de la Escala de Dificultades en la Regulación Emocional en adultos del Área Metropolitana de Buenos Aires
Authors: Cremades Camila , Garay Cristian Javier , Etchevers Martín Juan , Muiños Roberto , Peker Graciela Mónica , Gómez Penedo Juan Martín 
Published: October 2023

La desregulación emocional (de) fue identificada como uno de los principales procesos involucrados en el surgimiento y mantenimiento de los trastornos emocionales. A su vez, los trastornos emocionales son los más prevalentes mundialmente, volviendo a la de un objeto de estudio de gran relevancia. El presente trabajo consiste en la adaptación y validación de la Escala de Dificultades en la Regulación Emocional (Difficulties in Emotion Regulation Scale, ders) (Gratz & Roemer, 2004), para ser usada en población general del Área Metropolitana de Buenos Aires. Se realizó un estudio transversal con 315 participantes entre 18 y 65 años. La consistencia interna resultó adecuada (α = 0.936; ω = 0.938). Se llevó a cabo un análisis factorial confirmatorio mediante el paquete Lavaan, quedando la escala conformada por 30 ítems que se ajustan a las seis dimensiones originales. También se presenta evidencia de validez convergente y discriminante, la capacidad de discriminación de los ítems, diferencias por sexo y edad, y valores normativos para adultos del Área Metropolitana de Buenos Aires. La adaptación al español de la ders representa una herramienta válida y confiable para medir distintos aspectos del proceso de regulación emocional.
Terawatt-level 2.4-µm pulses based on Cr:ZnS chirped pulse amplification
Authors: Lu Xiaoming , Wang Xinliang , Fan Jintai , Xu Rongjie , Chen Junchi , Zhang Long , Leng Yuxin 
Published: October 2023

Chromium-doped chalcogenides, with broad and high emission
cross-sections near 2.4 µm, are very suitable for
generating high-peak-power pulses in the short-wave infrared range. In
this Letter, we demonstrate a TW-level system with a repetition rate
of 1 Hz by using Cr:ZnS as the gain medium. The seed pulse was
amplified to over 200 mJ via two stages of amplification. To
achieve the optimized amplified output, we combined Cr:ZnS elements to
absorb more pump energy and used the ink-cladding technique to
suppress the transverse parasitic lasing inside the Cr:ZnS elements.
After compression, we obtained a 147.1-mJ pulse with a duration of
127.6 fs, corresponding to a peak power output of
0.95 TW.
The seroincidence of childhood Shigella sonnei infection in Ho Chi Minh City, Vietnam
Authors: Jones Nick K. , Thu Trang Nguyen Hoang , de Alwis Ruklanthi , Thompson Corinne , Tuyen Ha Thanh , Nhu Tran Do Hoang , Phat Voong Vinh , Trung Pham Duc , Lam Phung Khanh , Tien Bui Thi Thuy , Tuyet Hoang Thi Diem , Vi Lu Lan , Van Vinh Chau Nguyen , Le Thi Quynh Nhi , Baker Stephen 
Published: October 2023

Background
Shigella sonnei is a pathogen of growing global importance as a cause of diarrhoeal illness in childhood, particularly in transitional low-middle income countries (LMICs). Here, we sought to determine the incidence of childhood exposure to S. sonnei infection in a contemporary transitional LMIC population, where it represents the dominant Shigella species.

Methods
Participants were enrolled between the age of 12–36 months between June and December 2014. Baseline characteristics were obtained through standardized electronic questionnaires, and serum samples were collected at 6-month intervals over two years of follow-up. IgG antibody against S. sonnei O-antigen (anti-O) was measured using an enzyme-linked immunosorbent assay (ELISA). A four-fold increase in ELISA units (EU) with convalescent IgG titre >10.3 EU was taken as evidence of seroconversion between timepoints.

Results
A total of 3,498 serum samples were collected from 748 participants; 3,170 from the 634 participants that completed follow-up. Measures of anti-O IgG varied significantly by calendar month (p = 0.03). Estimated S. sonnei seroincidence was 21,451 infections per 100,000 population per year (95% CI 19,307–23,834), with peak incidence occurring at 12–18 months of age. Three baseline factors were independently associated with the likelihood of seroconversion; ever having breastfed (aOR 2.54, CI 1.22–5.26), history of prior hospital admission (aOR 0.57, CI 0.34–0.95), and use of a toilet spray-wash in the household (aOR 0.42, CI 0.20–0.89).

Conclusions
Incidence of S. sonnei exposure in Ho Chi Minh City is substantial, with significant reduction in the likelihood of exposure as age increases beyond 2 years.