bluuebunny/crossref_metadata_2025_split huggingface dataset:
PTEN-induced kinase 1 gene single-nucleotide variants as biomarkers in adjuvant chemotherapy for colorectal cancer: a retrospective study
Authors: Mihara Yoshiaki , Hirasaki Masataka , Horita Yosuke , Fujino Takashi , Fukushima Hisayo , Kamakura Yasuo , Uranishi Kousuke , Hirano Yasumitsu , Ryozawa Shomei , Yasuda Masanori , Makino Yoshinori , Shibazaki Satomi , Hamaguchi Tetsuya 
Published: October 2023

Abstract
Background
Fluoropyrimidine-based postoperative adjuvant chemotherapy is globally recommended for high-risk stage II and stage III colon cancer. However, adjuvant chemotherapy is often associated with severe adverse events and is not highly effective in preventing recurrence. Therefore, discovery of novel molecular biomarkers of postoperative adjuvant chemotherapy to identify patients at increased risk of recurrent colorectal cancer is warranted. Autophagy (including mitophagy) is activated under chemotherapy-induced stress and contributes to chemotherapy resistance. Expression of autophagy-related genes and their single-nucleotide polymorphisms are reported to be effective predictors of chemotherapy response in some cancers. Our goal was to evaluate the relationship between single-nucleotide variants of autophagy-related genes and recurrence rates in order to identify novel biomarkers that predict the effect of adjuvant chemotherapy in colorectal cancer.

Methods
We analyzed surgical or biopsy specimens from 84 patients who underwent radical surgery followed by fluoropyrimidine-based adjuvant chemotherapy at Saitama Medical University International Medical Center between January and December 2016. Using targeted enrichment sequencing, we identified single-nucleotide variants and insertions/deletions in 50 genes, including autophagy-related genes, and examined their association with colorectal cancer recurrence rates.

Results
We detected 560 single-nucleotide variants and insertions/deletions in the target region. The results of Fisher’s exact test indicated that the recurrence rate of colorectal cancer after adjuvant chemotherapy was significantly lower in patients with the single-nucleotide variants (c.1018G > A [p < 0.005] or c.1562A > C [p < 0.01]) of the mitophagy-related gene PTEN-induced kinase 1.

Conclusions
The two single-nucleotide variants of PINK1 gene may be biomarkers of non-recurrence in colorectal cancer patients who received postoperative adjuvant chemotherapy.
Giant muscle hydatid in lower extremity: a rare case with neurological symptoms as the first manifestation
Authors: Jia Qiyu , Wu Shuo , Guo Jian , Alimujiang Abudusalamu , Zheng Hao , Zhang Jun , Wang Yingbo , Xie Zengru , Ma Chuang 
Published: October 2023

Abstract
Background
Human hydatid disease typically occurs in organs such as the liver and kidney. Primary solitary intramuscular hydatid disease, however, is rare.

Case Presentation
We report a case of a giant muscle hydatid in the lower extremity, with neurological symptoms as the first manifestation. The symptoms specifically manifested as intermittent pain in the right lower extremity and numbness in the sole of the right foot. However, there were no obvious abnormalities detected in electromyography and lumbar MRI. Subsequent ultrasonography and calf MRI showed that the patient had cystic lesions in the calf. The patient was initially diagnosed with a muscle hydatid cyst. Treatment involved complete surgical excision of the lesion, and the diagnosis of a hydatid cyst was confirmed through macroscopic and microscopic histopathological examination after the mass was excised. The patient was given oral albendazole, and no recurrence was observed during the 12 months of follow-up.

Conclusions
This case underscores the need to consider hydatid disease when diagnosing soft tissue masses in muscles, particularly in endemic areas. Patients may initially present with atypical symptoms like peripheral nerve issues.
Improving MR image quality with a multi-task model, using convolutional losses
Authors: Simkó Attila , Ruiter Simone , Löfstedt Tommy , Garpebring Anders , Nyholm Tufve , Bylund Mikael , Jonsson Joakim 
Published: October 2023

Abstract
Purpose
During the acquisition of MRI data, patient-, sequence-, or hardware-related factors can introduce artefacts that degrade image quality. Four of the most significant tasks for improving MRI image quality have been bias field correction, super-resolution, motion-, and noise correction. Machine learning has achieved outstanding results in improving MR image quality for these tasks individually, yet multi-task methods are rarely explored.

Methods
In this study, we developed a model to simultaneously correct for all four aforementioned artefacts using multi-task learning. Two different datasets were collected, one consisting of brain scans while the other pelvic scans, which were used to train separate models, implementing their corresponding artefact augmentations. Additionally, we explored a novel loss function that does not only aim to reconstruct the individual pixel values, but also the image gradients, to produce sharper, more realistic results. The difference between the evaluated methods was tested for significance using a Friedman test of equivalence followed by a Nemenyi post-hoc test.

Results
Our proposed model generally outperformed other commonly-used correction methods for individual artefacts, consistently achieving equal or superior results in at least one of the evaluation metrics. For images with multiple simultaneous artefacts, we show that the performance of using a combination of models, trained to correct individual artefacts depends heavily on the order that they were applied. This is not an issue for our proposed multi-task model. The model trained using our novel convolutional loss function always outperformed the model trained with a mean squared error loss, when evaluated using Visual Information Fidelity, a quality metric connected to perceptual quality.

Conclusion
We trained two models for multi-task MRI artefact correction of brain, and pelvic scans. We used a novel loss function that significantly improves the image quality of the outputs over using mean squared error. The approach performs well on real world data, and it provides insight into which artefacts it detects and corrects for. Our proposed model and source code were made publicly available.
Factors affecting the benefit of glasses alone in treating childhood amblyopia: an analysis of PEDIG data
Authors: Hernández-Andrés Rosa , Luque María Josefa , Serrano Miguel-Ángel , Scally Andrew , Barrett Brendan T 
Published: September 2023

Abstract
Background
To evaluate factors associated with better outcomes from optical treatment alone in amblyopic children from 3 up to 7 years.

Methods
Data extracted from two studies with similar protocols, Amblyopic Treatment Studies 5 (n = 152) and 13 (n = 128) from the Pediatric Eye Disease Investigator Group database, were used to determine by regression analysis the factors associated with improvements in visual acuity in the amblyopic eye, inter-ocular visual acuity difference and stereoacuity. Input variables were aetiology of amblyopia (anisometropic, strabismic and combined-mechanism amblyopia), treatment compliance, visual acuity, interocular visual acuity difference, stereoacuity, tropia size at distance and near, age and refractive error at baseline.

Results
Despite the range of clinical factors considered, our models explain only a modest proportion of the variance in optical treatment outcomes. The better predictors of the degree of optical treatment success in amblyopic children are visual acuity of the amblyopic eye, interocular visual acuity difference, stereoacuity, treatment compliance and the amblyopic eye spherical-equivalent refractive error. While the aetiology of the amblyopia does not exert a major influence upon treatment outcome, combined-mechanism amblyopes experience the smallest improvement in visual acuity, tropia and stereoacuity and may need longer optical treatment periods.

Conclusions
While results identify the factors influencing optical treatment outcome in amblyopic children, clinicians will be unable to predict accurately the benefits of optical treatment in individual patients. Whether this is because relevant clinical or non-clinical factors (e.g. nature and volume of daily activities undertaken) influences the outcomes from optical treatment has not yet been identified and remains to be discovered.
How do teenagers sleep? Analysis of factors related to sleep disorders in a group of Polish high school students
Authors: Tatar Dominika , Dębski Paweł , Bocian Bogusława , Bąkowska Małgorzata , Będkowska Joanna , Tropiejko Magda , Główczyński Patryk , Badura-Brzoza Karina 
Published: October 2023

Abstract
Summary
Insomnia is the most common sleep disorder in the adolescent population. Resulting from a complex interplay of genetic, biological, social, and environmental factors, it affects disturbances in everyday functioning in many aspects of life. The aim of the study was to analyze the factors related to the occurrence of insomnia among high school students.

Material
The study was conducted among 2364 high school students aged between 14 and 19 years old (the average age 17.92 ± 1.10), of which there were 2068 girls and 295 boys.

Method
Athens Insomnia Scale (AIS) and authorial demographic data questionnaire involved questions about physical activity during the day, smoking, frequency of upper respiratory tract infections, problems with concentration and memory, school achievements, and the use of mobile devices at bedtime were used to assess examined parameters. The scale and questionnaires were shared on-line via social media.

Results
Analyzing the results obtained in the study group, the average score of 8.42 ± 4.16 was obtained in the AIS, which allows the assessment of sleep disorders bordering on normal. After division into groups of girls and boys, 8.38 ± 4.56 points were obtained, respectively for girls and 8.43 ± 4.27pts. for boys - the difference was not statistically significant. Similarly, statistically significant differences were not found when dividing the groups into the one in which adolescents used the phone just before bedtime and the one that did not use it. The act of sleeping alone or with another person in the room also did not differentiate the groups statistically, as well as the place of residence. Statistically significant worse results in the AIS scale were obtained by people who declared worse physical activity during the day and smoking cigarettes, as well as those who reported more frequent problems with concentration and memory, had worse school performance and suffered from upper respiratory infections more often.

Conclusions
1). Sleep disorders may be related to factors such as smoking cigarettes or lack of physical activity, as well as difficulties in concentrating attention, memory disorders or worse academic performance and a tendency to contract upper respiratory tract infections. 2). Elimination of factors that may adversely affect the quality of sleep is particularly important in the group of adolescents, in whom the developing structures of the central nervous system may be particularly sensitive to deficiencies in this area. 3). Exploration of the interplay of study duration, screen time, and semester-specific stressors on sleep quality could yield further insights.
Depression and associated factors among Brazilian adults: the 2019 national healthcare population-based study
Authors: Hintz Alexandre Marcelo , Gomes-Filho Isaac Suzart , Loomer Peter Michael , de Sousa Pinho Paloma , de Santana Passos-Soares Johelle , Trindade Soraya Castro , Cerqueira Eneida de Moraes Marcílio , Alves Claudia Maria Coêlho , Rios Yasmine Silva Santos , Batista Josicélia Estrela Tuy , Figueiredo Ana Claudia Morais Godoy , Cruz Simone Seixas da 
Published: September 2023

Abstract
Background
Mental disorders represent a major public health challenge worldwide, affecting 80% of people living in low- and middle-income countries. Depression, a mental disorder, is a chronic disease of long duration that causes changes in the brain, resulting from a combination of genetic, physiologic, environmental, and behavioral factors. The aim of this study was to investigate possible factors associated with depression in Brazilian adults.

Methods
A population-based, cross-sectional study was carried out using the public domain database of the 2019 National Health Survey, conducted in Brazil. Depression was considered the dependent variable, and through hierarchical analysis, predictor variables were investigated such as, at the distal level—socioeconomic variables, at the intermediate level—variables related to lifestyle behavior, health condition, and history, and at the proximal level—demographic variables. Logistic regression analysis was used to obtain the adjusted Odds Ratio and the respective 95% confidence interval to identify possible factors associated with depression.

Results
The study included 88,531 participant records with 10.27% diagnosed with depression. The adjusted association measurements, after selecting the independent variables in the hierarchical analysis, showed the following factors associated with depression with differing magnitudes: age, brown and white race/skin color, female sex, poor, very poor, or regular self-reported health condition, diagnosis of cardiovascular disease, work-related musculoskeletal disorder, history of smoking habit, and macroeconomic region.

Conclusions
An effective strategy for preventing and managing depression in Brazilian adults must include the control of health status and lifestyle behavior factors, with actions and programs to reduce people's exposure to these factors, understanding that socioeconomic-demographic differences of each population can potentially reduce the disease burden.
Japanese public health nurses classified based on empathy and secondary traumatic stress: variable-centered and person-centered approaches
Authors: Kitano Masato , Shoji Kotaro , Nakaita Ikumi , Sano Shinya , Tachibana Shoichi , Shigemura Jun , Tachimori Hisateru , Noguchi Norihito , Waki Fumiko , Edo Naoki , Koga Minori , Toda Hiroyuki , Yoshino Aihide , Nagamine Masanori 
Published: October 2023

AbstractBackgroundHealthcare providers frequently help traumatized people and are regularly exposed to indirect trauma from their work, resulting in negative psychological responses, such as secondary traumatic stress. Empathy has been associated with patient’s quality of care and secondary traumatic stress among healthcare providers. However, the relationship between dispositional empathy and secondary traumatic stress has not been fully elucidated. This study used person- and variable-centered approaches to explore the nature of this relationship.MethodsA total of 1,006 Japanese public health nurses working in the Tohoku region and Saitama prefecture completed questionnaires that included scales assessing dispositional empathy, secondary traumatic stress, and burnout. First, we examined predictors of secondary traumatic stress using multiple linear regression analysis. Then, we conducted a latent profile analysis to classify participants into unique groups based on four subscales of dispositional empathy (i.e., empathic concern, perspective taking, personal distress, fantasy) and secondary traumatic stress. Finally, we compared the mean values of the study variables across these groups.ResultsThe multiple regression indicated that in those working in Saitama prefecture, lifetime traumatic experiences, work-related distress, and personal distress were positively related to secondary traumatic stress, but perceived support was negatively related to secondary traumatic stress. Latent profile analysis extracted four unique subgroups. Group 1 displayed the highest secondary traumatic stress levels. Group 2 was characterized by the highest level of empathic concern, personal distress, and fantasy and the lowest perspective taking. Group 3 had a moderate secondary traumatic stress level. Group 4 had the lowest secondary traumatic stress and personal distress scores. In these four groups, the burnout scale (exhaustion, cynicism, and professional efficacy) showed a pattern similar to the secondary traumatic stress scale.ConclusionsOur person-centered approach showed that this sample of public health nurses could be classified into four unique groups based on their empathy and secondary traumatic stress scores. Although this group of public health nurses was not large, one group displayed high personal distress levels and high secondary traumatic stress levels. Further research is needed to determine effective interventions for this group.
The epidemiology of varicella and effectiveness of varicella vaccine in Ganyu, China: a long-term community surveillance study
Authors: Qiu Lingxian , Liu Sheng , Zhang Minglei , Zhong Guohua , Peng Siying , Quan Jiali , Lin Hongyan , Hu Xiaowen , Zhu Kongxin , Huang Xingcheng , Peng Junchao , Huang Yue , Huang Shoujie , Wu Ting , Xu Jinbo , Dong Zifang , Liang Qi , Wang Wei , Su Yingying , Zhang Jun , Xia Ningshao 
Published: September 2023

Abstract
Background
The real-world data of long-term protection under moderate vaccination coverage is limited. This study aimed to evaluate varicella epidemiology and the long-term effectiveness under moderate coverage levels in Ganyu District, Lianyungang City, Jiangsu Province.

Methods
This was a population-based, retrospective birth cohort study based on the immunization information system (IIS) and the National Notifiable Disease Surveillance System (NNDSS) in Ganyu District. Varicella cases reported from 2009 to 2020 were included to describe the epidemiology of varicella, and eleven-year consecutive birth cohorts (2008–2018) were included to estimate the vaccine effectiveness (VE) of varicella by Cox regression analysis.

Results
A total of 155,232 native children and 3,251 varicella cases were included. The vaccination coverage was moderate with 37.1%, correspondingly, the annual incidence of varicella infection increased 4.4-fold from 2009 to 2020. A shift of the varicella cases to older age groups was observed, with the peak proportion of cases shifting from 5–6 year-old to 7–8 year-old. The adjusted effectiveness of one dose of vaccine waned over time, and the adjusted VE decreased from 72.9% to 41.8% in the one-dose group.

Conclusions
The insufficient vaccination coverage (37.1%) may have contributed in part to the rising annual incidence of varicella infection, and a shift of varicella cases to older age groups occurred. The effectiveness of one dose of varicella vaccine was moderate and waned over time. It is urgent to increase varicella vaccine coverage to 80% to reduce the incidence of varicella and prevent any potential shift in the age at infection in China.
Alcohol policy framing in South Africa during the early stages of COVID-19: using extraordinary times to make an argument for a new normal
Authors: Bartlett Andrew , Lesch Matthew , Golder Su , McCambridge Jim 
Published: September 2023

Abstract
Introduction
Public health and alcohol industry actors compete to frame alcohol policy problems and solutions. Little is known about how sudden shifts in the political context provide moments for policy actors to re-frame alcohol-related issues. South Africa’s temporary bans on alcohol sales during the COVID-19 pandemic offered an opportunity to study this phenomenon.

Methods
We identified Professor Charles Parry from the South African Medical Research Council as a key policy actor. Parry uses a Twitter account primarily to comment on alcohol-related issues in South Africa. We harvested his tweets posted from March 18 to August 31, 2020, coinciding with the first two alcohol sales bans. We conducted a thematic analysis of the tweets to understand how Parry framed alcohol policy evidence and issues during these ‘extraordinary times.’

Results
Parry underlined the extent of alcohol-related harm during ‘normal times’ with scientific evidence and contested industry actors’ efforts to re-frame relevant evidence in a coherent and well-constructed argument. Parry used the temporary sales restrictions to highlight the magnitude of the health and social harms resulting from alcohol consumption, particularly trauma, rather than the COVID-19 transmission risks. Parry portrayed the sales ban as a policy learning opportunity (or ‘experiment’) for South Africa and beyond.

Conclusions
Crisis conditions can provide new openings for public health (and industry) actors to make salient particular features of alcohol and alcohol policy evidence.
Integration measurement and its applications in low- and middle-income country health systems: a scoping review
Authors: Neill Rachel , Zia Nukhba , Ashraf Lamisa , Khan Zainab , Pryor Wesley , Bachani Abdulgafoor M. 
Published: September 2023

Abstract
Background
Despite growing interest in and commitment to integration, or integrated care, the concept is ill-defined and the resulting evidence base fragmented, particularly in low- and middle-income countries (LMICs). Underlying this challenge is a lack of coherent approaches to measure the extent of integration and how this influences desired outcomes. The aim of this scoping review is to identify measurement approaches for integration in LMICs and map them for future use.

Methods
Arksey and O’Malley’s framework for scoping reviews was followed. We conducted a systematic search of peer-reviewed literature measuring integration in LMICs across three databases and screened identified papers by predetermined inclusion and exclusion criteria. A modified version of the Rainbow Model for Integrated Care guided charting and analysis of the data.

Results
We included 99 studies. Studies were concentrated in the Africa region and most frequently focused on the integration of HIV care with other services. A range of definitions and methods were identified, with no single approach for the measurement of integration dominating the literature. Measurement of clinical integration was the most common, with indicators focused on measuring receipt of two or more services provided at a single point of time. Organizational and professional integration indicators were focused on inter- and intra-organizational communication, collaboration, coordination, and continuity of care, while functional integration measured common information systems or patient records. Gaps were identified in measuring systems and normative integration. Few tools were validated or publicly available for future use.

Conclusion
We identified a wide range of recent approaches used to measure integration in LMICs. Our findings underscore continued challenges with lack of conceptual cohesion and fragmentation which limits how integration is understood in practice.