bluuebunny/crossref_metadata_2025_split huggingface dataset:
Immune checkpoint status and exhaustion‐related phenotypes of CD8+ T cells from the tumor‐draining regional lymph nodes in breast cancer
Authors: Yilmaz Izel , Tavukcuoglu Ece , Horzum Utku , Yilmaz Kerim Bora , Akinci Melih , Gulcelik Mehmet Ali , Oral Haluk Barbaros , Esendagli Gunes 
Published: December 2023

AbstractBackgroundFunctional status of T cells determines the responsiveness of cancer patients to immunotherapeutic interventions. Even though T cell‐mediated immunity is inaugurated in the tumor‐adjacent lymph nodes, peripheral blood has been routinely sampled for testing the immunological assays. The purpose of this study is to determine the immune checkpoint molecule expression and the exhaustion‐related phenotype of cytotoxic T cells in the regional lymph nodes from breast cancer patients.Patients and methodsMulticolor immunophenotyping was used to determine the expression of PD‐1, TIM‐3, LAG3, CTLA‐4, CCR7, CD45RO, CD127, CD25, CXCR5, and ICOS molecules on CD3+CD4−CD56−CD8+ cytotoxic T cells freshly obtained from the lymph nodes and the peripheral blood samples of the breast cancer patients. The results were assessed together with the clinical data.ResultsA population of cytotoxic T cells was noted with high PD‐1 and CXCR5 expression in the lymph nodes of the breast cancer patients. Co‐expression of PD‐1, CXCR5, TIM‐3, and ICOS indicated a follicular helper T cell (Tfh)‐like, exhaustion‐related immunophenotype in these cytotoxic T cells. Only a minor population with CTLA‐4 and LAG3 expression was noted. The PD‐1+CXCR5+ cytotoxic T cells largely displayed CD45RO+CCR7+ central memory markers. The amount of CXCR5‐expressing PD‐1− cytotoxic T cells was elevated in the lymph nodes of the patients.ConclusionThe regional lymph nodes of breast cancer patients harbor Tfh‐like exhausted cytotoxic T lymphocytes with high PD‐1 and TIM‐3 checkpoint molecule expression. The immunological conditions in the regional lymph nodes should be implicated for immune checkpoint immunotherapy (ICI) of cancer.
The more diverse the better: Identifying with a diverse neighbourhood mother community predicts greater intergroup contact
Authors: Riikonen Reetta , Finell Eerika , Seppälä Tuija , Stevenson Clifford 
Published: December 2023

AbstractAlthough it has been shown that identification with a neighbourhood community can support intergroup relations within the community by providing resources to cope with intergroup contact, previous research has not investigated how the perceived diversity of the neighbourhood identity influences this process. This study extends research on neighbourhood identification by focusing on a specific group (mothers of small children), examining how and when identification with other mothers living in the same neighbourhood is related to intergroup contact with local outgroup mothers. We examined this in a survey study, for which we collected data from both Finnish majority and immigrant mothers at public maternal and child healthcare centres (N = 733). Our study showed that identification with the neighbourhood mother community was positively associated with intergroup contact, partly via perceived social support from other neighbourhood mothers for both Finnish majority and immigrant mothers. Our study additionally revealed that the perceived proportion of outgroup mothers in the local mother community moderated the relationship between identification and intergroup contact for both groups. Our findings highlight the significance of considering perceived diversity for determining when identification will support intergroup contact. Please refer to the Supplementary Material section to find this article's Community and Social Impact Statement.
Understanding the consumer's luxury webrooming intention: Moderating role of perceived risk and review
Authors: Akram Umair , Lavuri Rambabu 
Published: December 2023

AbstractThis research aims to examine luxury shoppers' webrooming intention, mediating (utilitarian value and hedonic value), and moderating (online perceived risk and reviews) effects. We used the stimulus‐organism‐response theory to provide a solid and holistic understanding of the concept. We collected 431 original survey data from Indian luxury shoppers who recently purchased luxury products and used structural equation modeling for data analysis. Results show that consumer traits (need for interaction and need for touch) had a positive impact on the perceived values (hedonic and utilitarian value) and webrooming intention. Channel‐related factors such as perceived ease of use had a direct impact on the hedonic value, while perceived usefulness had a direct impact on utilitarian value. Perceived values (hedonic and utilitarian values) positively mediated the channel and consumer traits factors and webrooming intent. Online perceived risk and reviews significantly moderated the relationship between perceived value and webrooming intent. This study adds to the knowledge of luxury marketing by analyzing webrooming and channel flipping.
Bottom‐Up Construction of Ni(II)‐Incorporated Covalent Organic Framework for Metallaphotoredox Catalysis
Authors: Hu Hai‐Chao , Wang Zhi‐Peng , Liang Lin , Du Xin‐Yu , Li Ting , Feng Jie , Xiao Tian‐Tian , Jin Ze‐Ming , Ding San‐Yuan , Liu Qiang , Lu Liang‐Qiu , Xiao Wen‐Jing , Wang Wei 
Published: December 2023

AbstractThe construction of an all‐in‐one catalyst, in which the photosensitizer and the transition metal site are close to each other, is important for improving the efficiency of metallaphotoredox catalysis. However, the development of convenient synthetic strategies for the precise construction of an all‐in‐one catalyst remains a challenging task due to the requirement of precise installation of the catalytic sites. Herein, we have successfully established a facile bottom‐up strategy for the direct synthesis of Ni(II)‐incorporated covalent organic framework (COF), named LZU‐713@Ni, as a versatile all‐in‐one metallaphotoredox catalyst. LZU‐713@Ni showed excellent activity and recyclability in the photoredox/nickel‐catalyzed C−O, C−S, and C−P cross‐coupling reactions. Notably, this catalyst displayed a better catalytic activity than its homogeneous analogues, physically mixed dual catalyst system, and, especially, LZU‐713/Ni which was prepared through post‐synthetic modification. The improved catalytic efficiency of LZU‐713@Ni should be attributed to the implementation of bottom‐up strategy, which incorporated the fixed, ordered, and abundant catalytic sites into its framework. This work sheds new light on the exploration of concise and effective strategies for the construction of multifunctional COF‐based photocatalysts.
Ca(II) and Yb(II) complexes featuring M(C≡C)4 structural motif: enforced proximity or genuine η2‐bonding?
Authors: Lyubov Dmitry M. , Zakaria Hamza , Nelyubina Yulia V. , Aysin Rinat R. , Bukalov Sergey S. , Trifonov Alexander A. 
Published: December 2023

AbstractBis(carbazolide) complexes M[3,6‐tBu2‐1,8‐(RC≡C)2Carb]2(THF)n (R=SiMe3, n=0, M=Ca, Yb; R=Ph, n=1, M=Ca, Yb; n=0, M=Yb) were synthesized through transamination reaction of M[N(SiMe3)2]2(THF)2 with two molar equivalents of carbazoles. The complexes feature M(η2‐C≡C)4 structural motif composed of M(II) ions encapsulated by four acetylene fragments due to atypical for alkaline‐ and rare‐earth metals η2‐interactions with triple C≡C bond. This interaction is evidenced experimentally by X‐ray diffraction, Raman spectroscopy in the solid state and by NMR‐spectroscopy in the solution. According to QTAIM analysis there are 4 bond critical points (3;−1) between the metal atom and each of the triple bonds, which are connected by a strongly curved, almost T‐shaped bond pathway.
Palladium Complexes with N,O‐Bidentate Ligands Based on N‐Oxide Units from Cyclic Secondary Amines: Synthesis and Catalytic Application in Mizoroki‐Heck Reaction
Authors: Jia Xuefeng , Wen Yanyan , He Changhui , Huang Xianqiang 
Published: December 2023

Comprehensive SummaryPalladium‐catalyzed Mizoroki‐Heck reaction is a powerful and efficient method for construction of Csp2–Csp2 bonds. Herein, four palladium complexes (I—IV) with N,O‐bidentate ligands (L1—L4) based on N‐oxide units from cyclic secondary amines were easily synthesized and successfully applied in Mizoroki‐Heck reaction of aryl bromides with electron‐deficient olefins. X‐ray diffraction analyses indicated the palladium(II) atom of II took the distorted square planar geometry and was four‐coordinated by nitrogen and oxygen atoms from two ligands (L2). Two free chloride ions were presented as counter anions in complex II. But the palladium(II) center of IV was coordinated by nitrogen and oxygen atoms from one ligand (L4) as well as two chlorine atoms, which exhibited the nearly square‐planar geometry. The study on catalytic properties of palladium complexes revealed that complex II exhibited high activity superior to the other complexes. The coupling reactions of a series of aryl bromides and olefin derivatives proceeded in the presence of 2—5 mol% palladium complex II, giving the desired products in good to excellent yields. The advantages of this method such as good compatibility of functional groups, high yields, and short reaction times made it more attractive for constructing Csp2–Csp2 bonds in the synthesis of functional molecules and materials.
Femoral vessel complications after transfemoral TAVR—A contemporary sonography‐based assessment of 480 patients with third‐generation transcatheter valves
Authors: Werner Paul , Winter Martin , Müller Markus , Zierfuss Bernhard , Coti luliana , Mach Markus , Scherzer Sabine , Simon Paul , Laufer Günther , Willfort‐Ehringer Andrea , Andreas Martin 
Published: December 2023

AbstractBackgroundPostinterventional sonographic assessment of the femoral artery after transfemoral transcatheter aortic valve replacement (TF‐TAVR) has the potential to identify several pathologies. We investigated the incidence and risk factors of femoral vessel complications in a modern TAVR collective using postinterventional sonography.MethodsBetween September 2017 and March 2022, 480 patients underwent TF‐TAVR with postinterventional femoral sonography at a single center. Clinical outcomes and adverse events were analyzed after the Valve Academic Research Consortium 3 (VARC‐3) criteria.ResultsIn this cohort (51.2% male; age 80 ± 7.5 years, median EuroSCORE II 3.7) 74.8% (n = 359) were implanted with a self‐expandable and 25.2% (n = 121) with a balloon‐expandable valve. The main access (valve‐delivery) was located right in 91.4% (n = 438), and the primary closure system was Proglide in 95% (n = 456). Vascular complications (VC) were observed in 29.16% (n = 140) of patients; 23.3% (n = 112) presented with minor‐ and 5.8% (n = 28) with major VC. Postinterventional femoral artery stenosis on the main access was observed in 9.8% (n = 47). Multivariable logistic regression analysis revealed female sex (p = .03, odds ratio [OR] 2.32, 95% confidence interval [CI] 1.09–4.89) and the number of used endovascular closure devices (p = .014, OR 0.11, 95%CI 0.02–0.64) as predictive factors for femoral artery stenosis.ConclusionsThe incidence of postinterventional femoral artery stenosis following TF‐TAVR was higher than expected with a number of used closure devices and female sex being independent risk factors. Considering the continuous advance of TAVR in low‐risk patients with preserved physical activity, emphasis should be directed at the correct diagnosis and follow‐up of these complications.
The role of risk management committee on the relationship between corporate carbon emission disclosure and capital structure
Authors: Ardianto Ardianto , Anridho Nadia , Cahyono Suham , Noman Alam Abu Hanifah Md. , Harymawan Iman 
Published: December 2023

AbstractThis study aims to examine the association between carbon emission disclosure and corporate capital structure, moderated by the presence of a risk management committee. Specifically, we aim to explore whether the existence of a risk management committee can mitigate the risks faced by companies when formulating capital structure strategies. We use data from non‐financial companies listed in the Carbon Disclosure Project (CDP) from 2015 to 2021 that disclose information on carbon emissions. To test our hypotheses, we employ fixed‐effects regression with standard error estimates. Our findings provide evidence that carbon emission disclosure is positively related to corporate capital structure, and that the moderating effect of the risk management committee is also positively associated with carbon emission disclosure and corporate capital structure. In addition, we conduct robustness and endogeneity tests, including Heckman (1979) two‐stage least squares, entropy balancing, propensity score matching, and two‐step GMM using Arellano‐Bond estimation. Furthermore, our study includes a batterary of cross‐sectional tests to rigorous the main findings. Finally, our study contributes to the literature on sustainable strategies and sustainable financing at the corporate level.
The impact of service experience on sustainable customer engagement: The mediation of green perceived value and customer satisfaction
Authors: Yan Dongwei , Wang Chenke , Sun Tianyi , Wen Decheng 
Published: December 2023

AbstractWith increasing public environmental awareness, accelerating green transformation has become inevitable for enterprises to achieve long‐term development. Sustainable customer engagement (sustainable CE) is a core concept of consumer participation in sustainable consumption. Based on partial least squares‐structural equation modeling, this study establishes a prediction model for sustainable CE and explores the impacts of service experience, green perceived value, and customer satisfaction on sustainable customer engagement. This study collected 682 valid data points from customers of green hotels and analyzed the relationships between sustainable CE and its antecedent variables. The results showed that peace of mind and product experience can directly promote sustainable customer engagement. Service experience can enhance sustainable CE through the serial mediation of green perceived value and customer satisfaction. The conclusions enrich the existing knowledge in the field of sustainable consumption and engagement marketing and provide effective suggestions for green hotel managers.
Acantholytic squamous cell carcinoma mimicking epithelioid angiosarcoma: A diagnostic challenge by cytology
Authors: Taweevisit Mana , Sutthiruangwong Piriya , Thorner Paul Scott 
Published: December 2023

AbstractSquamous cell carcinoma (SCC) is the most common malignancy of the head and neck region. Most cases present little diagnostic difficulty on fine needle aspiration (FNA), but unusual variants can be problematic. The authors report a case of the acantholytic SCC of the oral cavity in a 36‐year‐old male. The FNA showed hypercellularity, with malignant cells arranged in isolation, loosely cohesive groups and a linear configuration. Such cells were round to elongated, with vesicular nuclei and prominent nucleoli. Cells possessed occasional intracytoplasmic vacuoles, misinterpreted on FNA to be vasoformative features as seen in malignant endothelial cells. The cytologic diagnosis was “positive for malignancy, suggestive of angiosarcoma”. A total excision was performed and by histology, the tumor was diagnosed as acantholytic SCC. The malignant cells were positive by immunostaining for AE1/AE3, p40, p63 and vimentin, but negative for CD31, CD34 and ERG. The intracytoplasmic vacuoles were PAS‐ and mucin‐negative and negative for the above antibodies. Testing for HPV (molecular and p16 immunostaining) was negative. This case highlights the diagnostic challenges on cytology when malignant acantholytic squamous cells show intracytoplasmic vacuoles, and stresses how immunohistochemistry is important for distinguishing acantholytic SCC from other mimics.
Subtypes of exercise are differentially associated with baseline eating disorder pathology and treatment outcome among individuals with bulimia nervosa
Authors: Lampe Elizabeth W. , Hill Naomi G. , Schleyer Brooke , Giannone Alyssa , Juarascio Adrienne S. , Manasse Stephanie M. 
Published: December 2023

AbstractObjectiveIndividuals with bulimia nervosa (BN) engage in both maladaptive (i.e., compulsive and/or compensatory) and adaptive exercise (e.g., for enjoyment). No research has examined whether those who engage in adaptive, compulsive, and/or compensatory exercise exhibit differences in BN pathology or treatment outcome compared to those not engaging in exercise, limiting intervention efficacy.MethodWe examined associations of baseline exercise engagement with baseline and posttreatment BN pathology among 106 treatment‐seeking adults (Mage = 37.4, SDage = 12.95, 87.74% female, 68.87% White) enrolled across four clinical trials of outpatient enhanced cognitive behavioral therapy for BN (range: 12–16 sessions). Analysis of covariances examined associations between baseline exercise type and baseline/posttreatment global eating pathology, dietary restraint, loss‐of‐control (LOC) eating, and purging frequency.ResultsThose engaging in only adaptive exercise reported lower global eating pathology compared to those engaging in compulsive‐only exercise (Est = −1.493, p = .014, Mdiff = −.97) while those engaging in baseline compulsive exercise reported less LOC eating compared to those not engaging in exercise (Est = −22.42, p = .012, Mdiff = −12.50). Baseline engagement in compulsive‐only exercise was associated with lower posttreatment global eating pathology compared to baseline engagement in no exercise (Est = −.856, p = .023, Mdiff = −.64) and both compulsive and compensatory exercise (Est = .895, p = .026, Mdiff = −1.08).DiscussionThose engaging in compulsive, compensatory, adaptive, and no exercise exhibit different patterns and severity of BN pathology. Future research is needed to position treatments to intervene on maladaptive, while still promoting adaptive, exercise.Public significance statementNo research to date has examined whether those who engage in adaptive, compulsive, and/or compensatory exercise exhibit differences in BN pathology or treatment outcome compared to those not engaging in exercise, limiting targeted intervention efforts. We found that those engaging in compulsive, compensatory, and adaptive exercise exhibit different patterns of BN pathology and that adaptive exercise engagement was related to lower cognitive eating disorder symptoms at baseline.
Contrasting management regimes indicative of mesopredator release in temperate coastal fish assemblages
Authors: Synnes Ann‐Elin Wårøy , Olsen Esben Moland , Jorde Per Erik , Knutsen Halvor , Moland Even 
Published: December 2023

AbstractThe absence of functional top predators has been proposed as a mechanism acting to shape fish assemblages in temperate marine ecosystems, with cascading effects on lower trophic levels. We explore this scenario by comparing the trophic and functional status of fish assemblages in Norwegian marine national parks, open to fishing, to a nearby coastal seascape that harbors a system of marine protected areas (MPAs) including a no‐take zone. Demersal fish assemblages were sampled using fyke nets over three consecutive seasons. Atlantic cod (Gadus morhua) is potentially a dominant top predator in this ecosystem, and historically, this and other gadids have been targeted by the full range of former and present fisheries. In the present study, we find that average body size of the Atlantic cod was significantly larger in the zoned seascape compared to the unprotected areas (mean ± SD: 36.6 cm ± 14.38 vs. 23.4 ± 7.50; p < .001) and that the unprotected seascape was characterized by a higher abundance of mesopredator fish species. These observations are consistent with the hypothesis that the protection of top predators within MPAs aids to control the mesopredator populations and provides empirical support to the notion that the present state of many coastal fish assemblages is driven by mesopredator release linked to functional depletion of large top predators.
Solid oxide electrolysis stack development and upscaling
Authors: Di Iorio S. , Monnet T. , Palcoux G. , Ceruti L. , Mougin J. 
Published: December 2023

AbstractSolid oxide electrolysis is considered an efficient technology to produce hydrogen. To deploy electrolysers at the GW scale, an increase in the individual component size (cells and stacks in particular) is required. The integration of larger cells (200 cm2 active area) into 25‐cell stacks has been successfully performed. Performances were in the range of –0.8 to –0.9 A cm−2 at 1.3 V at 700°C. The number of cells has also been increased to 50 and 75 cells. For this latter 75‐cell stack, the assembly of three 25‐cell substacks was considered. Good gastightness and high performances were achieved, although connections between substacks add a serial resistance that affects the stack total performances. Nevertheless, a current density of more than –0.8 A cm−2 was obtained at 1.3 V and 700°C, consistent with individual substack performances. Finally, a stack made of 50 200 cm2 cells has been assembled. Although a stack deformation was visible due to individual component thickness scattering, a good gastighness was achieved and a current density of –0.9 A cm−2 at 1.3 V and 700°C was measured. The low voltage scattering highlighted a good homogeneity of the fluidic distribution and of the electrical contacts within the stack.
One out of ten independent components shows flipped polarity with poorer data quality: EEG database study
Authors: Miyakoshi Makoto , Kim Hyeonseok , Nakanishi Masaki , Palmer Jason , Kanayama Noriaki 
Published: December 2023

AbstractIndependent component analysis (ICA) is widely used today for scalp‐recorded EEG analysis. One of the limitations of ICA‐based analysis is polarity indeterminacy. It is not easy to find detailed documentations that explains engineering solutions of how the polarity indeterminacy is addressed in a given implementation. We investigated how it is implemented in the case of EEGLAB and also the relation between the outcome of the polarity determination and classification of independent components (ICs) in terms of the estimated nature of the sources (brain, muscle, eye, etc.) using an open database of n = 212 EEG dataset of resting state recordings. We found that (1) about 91% of ICs showed positive‐dominant IC scalp topographies; (2) positive‐dominant ICs were more associated with brain‐originated signals; (3) positive‐dominant ICs showed more radial (peaked at 10–30 degrees deviations from the radial axis) dipolar projection pattern with less residual variance from fitting the equivalent current dipole. In conclusion, using the EEGLAB's default ICA algorithm, one out of 10 ICs results in flipping its polarity to negative, which is associated with non‐radial dipole orientation with higher residual variance. Thus, we determined EEGLAB biases toward positive polarity in decomposing high‐quality brain ICs.