bluuebunny/crossref_metadata_2025_split huggingface dataset:
Predictors of lower response to COVID19 vaccine in people living with HIV. A 6-month follow-up study
Authors: Amoruso I , Fonzo M , Geppini R , Miccolis L , Serpentino M , Leoni D , Cattelan A , Baldo V , Baldovin T 
Published: October 2023

Abstract

Clinical trials demonstrated efficacy and safety of COVID-19 vaccines, although enrolment of immunocompromised individuals, including people living with HIV (PLWH), has been limited. Although cellular immunity is not negligible, recent evidence suggests a strong correlation between neutralising antibody titre and overall protection against infection. Our study aimed to identify potential predictors of lower response to vaccine in PLWH. We conducted a prospective study at the Padua University Teaching Hospital, Italy. Participants were vaccinated with a BNT162b2 2-dose schedule in early 2021. Non-naïve to SARS-CoV-2 were excluded. Anti-S titres were assessed using AdviseDx SARS-CoV-2 IgG II quantitative CMIA assay at 30, 90 and 180 days after completion of vaccination. Non-response was defined as &lt; 50 AU/mL and lower response as the lowest quartile. Information on age, sex, BMI, comorbidities, CD4 count, CD4/CD8, viral load was collected. The association between predictors and lower response was assessed using logistic and linear regression. We enrolled 180 individuals (15 excluded). Mean age 54.0±11.2 years; 17% females; 23% showed CD4 count &lt;500 (none &lt;200), while 18.2% CD4/CD8 &lt;0.5. All responded to vaccine at any follow-up time. Lower response was associated with dyslipidaemias (AOR 4.75; 95%CI: 1.39-16.20; 30 days) and diabetes (AOR 7.11; 95%CI: 1.10-46.10; 90 days), while 1-unit increase in BMI was associated with reduced risk (AOR 0.78; 95%CI 0.64-0.95; 90 days). No correlation was found between anti-S titre and CD4 count (β -0.057; p 0.52), CD4/CD8 (β 0.050; p 0.57) nor viral load (β -0.001; p 0.99). Response to vaccine is good and sustained in well controlled PLWH. Dyslipidaemias and diabetes are associated with a non-concerning lower response. Increased BMI as protective factor may reflect the effect of good nutritional status. Using CD4 count, CD4/CD8 or viral load does not appear to help predict vaccine response in well controlled HIV.

Key messages
• Well controlled People Living With HIV (PLWH) respond well to BNT162b2 vaccine, and neutralising antibody titres are maintained for up to 6 months after primary vaccination.
• PLWH with dyslipidaemias and diabetes have lower antibody persistence, although always above the threshold. Good nutritional status may contribute to longer antibody persistence.
Sars-CoV2 in wastewater: 2021-2023 surveillance in three provinces of Lombardia region (Italy)
Authors: Bertasi B , Galuppini E , Mangeri L , Tilola M , Righi F , Losio M N ,   Lombardia network for Sars-CoV2 wastewater surveillance
Published: October 2023

Abstract

Background
Sars-CoV2 pandemic has shown the importance of wastewater surveillance to monitor virus diffusion and its environmental permanence; WHO experts highlighted the importance of wastewater controls as early detection system to individuate Sars-CoV2 and other viruses which could potentially spread to the population. The aim of this work was to investigate the presence of Sars-CoV2 in wastewater from Brescia, Cremona and Bergamo cities during 2021-2023 years after pandemic event.

Methods
From the end of 2021 until now, 341 wastewater samples were collected and analyzed at Food Control department to detect Sars-CoV2. After the inactivation at 56 °C for 30 minutes, samples were centrifugated and extracted by eGENE-UP® system (bioMérieux). Virus detection was based on three genes amplification: ORF, N1 and N3. Quantification in genome copies/µL (cg/µL) was performed.

Results
Almost all samples were positive for virus presence; in particular ORF gene was detected in 94% of samples (IC95% 91,6 - 96,7%); the other genes N1 and N3 were detected respectively in 91% (IC95% 87,2 - 93,6) and 98% (IC95% 95 - 99%). In only three samples all genes simultaneously were not detected. ORF and N1 were quantified between 103 and 104 cg/µL without differences among seasons. N3 was quantified at higher values than the other genes (104 in 57% of samples; IC95% 51,4 - 62,2%).

Conclusions
The pandemic has run out with the safety measures applied, but wastewater surveillance has highlighted virus circulation, even if at lower, constant levels than in pandemic period. Virus quantity in wastewater followed and sometime preceded epidemic trend. Wastewater control could support competent authorities in epidemic event management.
Environmental surveillance, as already demonstrated during pandemic period, could represent an alert system for Sars-Cov2 and oral fecal route virus spreading

Key messages
• Wastewater surveillance is an important tool to control Sars-CoV2 mutation and spreading.
• Environmental viruses’ surveillance can support competent authorities in decisions regarding public health.
Sentiment towards vaccinations in healthcare workers of five European countries after the pandemic
Authors: Regazzi L , Cadeddu C , Valz Gris A , Lomazzi M 
Published: October 2023

Abstract

Background
Health care workers (HCWs) are a trusted source of vaccine information for patients and communities. Our aim is to evaluate the impact of the COVID-19 pandemic on European HCWs’ sentiment towards vaccination (STV), focusing on COVID-19 and influenza.

Methods
We designed a multilingual Knowledge-Attitudes-Practice web-survey with 4-point Likert items addressed to HCWs in 11 countries and spread through national Public Health Associations. We present a preliminary analysis of responses from France (n = 206), Germany (n = 376), Italy (n = 394), Spain (n = 549) and the United Kingdom (n = 172, UK).

Results
The completion rate is 81% (1,374/1,697). Respondents are mostly female (66%), with a median age of 45, mainly employed as physicians (44%). HCWs agree on the effectiveness (92%), safety (89%) and necessity (91%) of vaccinations in general, but many think that their side effects are downplayed by pharmaceutical companies (46%) and health authorities (39%). The majority received 3+ doses of COVID-19 vaccines (72%) and agree that these vaccines are effective (88%) and have a favorable benefit-risk ratio (83%). However, many have concerns about their administration in pregnancy (76%). Most HCWs agree with mandatory COVID-19 vaccine for their category (59%) and are ready to accept a further COVID-19 booster vaccination if recommended (72%). The majority agree that the pandemic increased their attention to update their vaccination schedule (62%) and their confidence in vaccines safety (53%). Accordingly, only 50% received regular influenza vaccination prior to the pandemic, whereas 67% got vaccinated in the last season and 65% plan to do so in the next one. Overall, STV is more positive in Italy and Spain, less marked in Italy has the lowest scores in Germany.

Conclusions
Despite persisting doubts about COVID-19 vaccines and differences among countries, the sentiment towards vaccinations in European HCWs is generally positive and has improved after the pandemic.

Key messages
• European healthcare workers have generally positive sentiment towards vaccination, including COVID-19 and influenza, despite concerns about side effects and about administration during pregnancy.
• The COVID-19 pandemic increased European HCWs’ attention to update their vaccination schedules, with the majority agreeing on the effectiveness, safety, and necessity of vaccinations in general.
Comparison of progress in CSE in Moldova measured by SERAT - from 2017 to 2022
Authors: Sirbu L , Lesco G , Gherciu C 
Published: October 2023

Abstract
In recent years in the Republic of Moldova, many actions have been carried out to develop health education programmes that integrate sexuality education, in both the compulsory and optional school curricula. Sexuality education is not a stand alone subject and was integrated mainly in two mandatory courses Biology and Personal Development. To assess the quality of school-based sexuality education in the country, UNFPA in the Republic of Moldova in partnership with the Ministry of Education and Research (MER), under a regional initiative supported by the UNFPA Eastern Europe and Central Asia Regional Office and the BZgA, conducted in 2021-2022 a national assessment of the compulsory curriculum by applying SERAT. To observe the progress over the last years, a comparative analysis was performed with the results from SERAT analysis conducted in Moldova in 2017. Overall, the results of the current assessment demonstrate a significant progress in the development of sexuality education programs since 2017, achieving a much higher score of compliance with the international standards for CSE in 2021/2022 - 54 per cent average score for all components compared to 34 per cent in 2017. The government is committed to increase the level of sexuality education integration in schools, as the legal framework provides strong support for the right to sexuality education for adolescents and youth.
Asian American & Pacific Islander SGM Emerging Adult Mental Health: Current Trends and Next Steps
Authors: Zhou S , Abelson S , Stojanovski K 
Published: October 2023

Abstract

Background
Asian American and Pacific Islander (AAPI) sexual and gender minority (SGM) young and emerging adults are an especially high-risk group to consider in mental health research, holding multiple marginalized identities & report discrimination based on race/ethnicity & immigration status at double the rate of overall SGM youth. There is a need for extensive national studies that capture the experience of AAPI SGM youth to comprehensively elucidate the mental health burden on this often-overlooked population in the COVID-19 era. This study aims to describe the national landscape of AAPI SGM university student mental health & treatment usage.

Methods
We data from the Healthy Minds Study, conducted between September 2021-May 2022 (n = 89,255) across 133 campuses in the United States. We used bivariate analyses & cross-sectional logistic regression models to evaluate mental health symptoms, risk/protective factors, & treatment utilization across AAPI SGM students.

Results
Preliminary findings indicate that 78% of AAPI SGM respondents report the presence of one or more positive screens for depression, anxiety, eating disorder, suicidal ideation, or non-suicidal self-injury. Among these students, approximately 57% report utilizing therapy or psychotropic medication. Experiences of discrimination & financial stress were the strongest correlates of mental health symptoms. Self-reported experiences of discrimination based on race, culture, & sexual orientation were associated with higher odds of treatment utilization for AAPI SGM domestic students but not for international students.

Conclusions
The data underscore the need to consider the adequacy of current approaches in supporting AAPI SGM mental health, as well as unique ways to foster protective institutional & intrapersonal factors & increase investments to culturally responsive, gender-affirming treatment & prevention programs that address mental health disparities already looming in minoritized communities.
Sustainalibity elements of the Best-ReMaP Joint Action
Authors: Silano M , Tonello S , Sienkiewicz D , Gabrijelčič M , Robnik Levart M , De Cosmi V 
Published: October 2023

Abstract
To enable sustainabile and effective uptake of recommended actions, key policy-relevant messages are conveyed: (1) enable the implementation of processed food monitoring and reformulation by ensuring personnel and resources for institutionalized actions at governmental level; re-establish platforms at European level like former HLG on nutrition and PA to facilitate knowledge exchange; (2) reduce the marketing of unhealthy foods to children via adoption of government-led regulatory approaches; policies cover the reduction, preferably the removal of marketing of unhealthy foods in a broad set of marketing types and techniques; raise the age threshold for marketing regulations to 18 years; define the foods and drink products to be restricted from marketing through a strict government-led NPM, based on the WHO Europe NPM, as outlined in the revised 2018 AVMSD; enforce a national food marketing code by an assigned national administrative body, and ensure financial and human resources to cover the workload related to food marketing monitoring; (3) support actions in public food procurement policies by the involvement of inter-sectoral collaboration in MSs; facilitate the policies in this field by collaboration with an EU public food procurement network to share knowledge and experiences among MSs; align the implementation of the public food procurement legislation for MSs; guarantee a sufficient budget for public food procurement and cooperate on the interventions with relevant sectors and stakeholders, such as the parents, communities. A Food System Sustainability Scoreboard was proposed as a mean of how to insert a monitoring mechanisms of the food system sustainability in the European Semester. DG JRC has elaborated on the FABLE testing branded foods EU open database. MSs are indicating the overall expressed need for re-establishing the high level collaboration in the areas of nutrition, physical activity and obesity at the EU level.
Enhancing the reuse of health data for research purposes: laws and regulations as pillars of trust
Authors: Verheij R , Van Veen E B 
Published: October 2023

Abstract

Background
Routinely recorded health data are increasingly used for research purposes and indispensable to stimulating appropriate and sustainable health care. In many countries access to data has proven to be a challenge. Trust by researchers, organisations and the general public is key, and adherence to the rule of law is one of the key elements determining that trust. We investigated the laws and regulations regarding the reuse of health data and how they work out practically for researchers.

Methods
Our study focuses on France, Finland, Denmark, Germany, England and The Netherlands. We investigated consent mechanisms, the possibilities of record linkage, and how the sharing of data for research purposes was organised, with a combination of desk research and interviews with researchers in these countries.

Results
All countries investigated except England are subject to the General Data Protection Regulation. However, explicit consent is the default in Germany and the Netherlands, while other countries maintain an opt-out system or even a system of neither consent nor opt-out. A central data access authority is in place in all countries investigated except Germany and the Netherlands. The nature and level of detail of data varies widely.

Conclusions
GDPR does not dictate a specific modality for the reuse of data. In terms of the reuse of health data, Germany and the Netherlands are lagging. The Netherlands seems to be the only country with continuing discussions about consent modalities. A broader societal debate about the balance between trust and the reuse of health data is needed, also against the background of a European Health Data Space. In the Netherlands, widespread government distrust is one of the challenges. Options to counteract this distrust will be discussed.

Key messages
• European countries vary in the way routine health data are accessible for research purposes.
• This will affect the feasibility of a uniform European Health Data Space.
Adopting population health management in PHC. Bridging needs and response
Authors: Cerezo Cerezo J 
Published: October 2023

Abstract
Population health management can substantially contribute to realizing some of PHC's central attributes, including person-centeredness; accessibility; comprehensiveness; attention to health problems in their physical, mental, social, cultural and existential dimensions; continuity; coordination and community orientation. It can do this by supporting PHC providers in:
• moving from a one-size-fits-all approach to targeted and tailored approaches that account for the needs of different groups within local catchment populations or population clusters with similar needs or health conditions;
• moving from passive and reactive to proactive care, ensuring that people with different risks are identified and have their care anticipated;
• moving from a narrow focus on clinical needs to a holistic approach focusing also on psychosocial needs and the social determinants of health; and
• moving from fragmented and poorly coordinated care to better coordination and integration with secondary and tertiary care and partnership with other sectors and actors in the community.
Although moving towards system-wide implementation of population health management requires several years of development work and takes time to achieve impact, population health management can promote improvements in PHC even before the full benefits of population health management are realized. Key and common success factors to enable population health management in PHC are described here as system (such as information governance arrangements that promote information sharing within and outside the health system, data stewardship capacity and skills or support of regulatory agencies); organizational (multidisciplinary and networked PHC models and integration and close collaboration with public health and social care agencies); and clinical-level factors (such as comprehensive and systematic data collection in PHC or patient and community engagement).
I used to think... now i think...
Authors: Shimocomaqui G 
Published: October 2023

Abstract
This activity will last 20 minutes, aiming to support the consolidation of the new learning. The method Thinking routine, developed by the Project Zero from Harvard Graduate School of Education will be used. Participants will be informed that the activity aims to support them to in reflecting on their thinking about the topic “Access to Health Care” and exploring how and why their thinking has changed. The panelist will guide participants with the following instructions: I. When we started this workshop about access to mental health care, you had some pre-thoughts about this topic. Take a minute to recall what you used to think about the topic and write a few sentences using the sentence starter, “I used to think...”. II. Now, think about whether and how your ideas about this topic have changed as result of what we discussed during the Access Game. Again, in just a few sentences, write what you think now about Access to mental Health Care. Start your sentences with, ‘Now, I think...’”. III. Sitting in a large circle, participants will be invited to share their thoughts and thus visualize the lessons learned from the workshop.
Participatory transferability analysis of vaccination interventions with underserved communities
Authors: Schloemer T , Hecht H , Horstman K 
Published: October 2023

Abstract

Background
The Horizon 2020 project RIVER-EU will remove health system barriers to childhood vaccination in the migrant community in Greece, the Turkish and Moroccan communities in the Netherlands, the Ukrainian minority in Poland, and the marginalized Roma community in Slovakia. In order to identify transferable vaccination interventions for HPV and MMR, our aim was to establish a collaboration with various stakeholders from these communities.

Methods
For the transferability analysis, we used the participatory action approach (PAR) to stimulate meaningful participation of different key stakeholder groups in discussing evidence-based interventions and the specific contextual conditions of the underserved communities. Based on the PIET-T models, we collaboratively explored characteristics of the populations (P), interventions (I), environments (E) as well as options for intervention transfer (T) to understand transferability (T), need for intervention adaptations or new interventions.

Results
Six interventions were pre-selected for decision-making. These addressed elements of involving community members to support vaccination, education in schools, providers’ vaccine communication, and educational videos. All partners co-created knowledge through their expertise: Community members contributed through their experiences with vaccination services, provided valuable arguments for or against interventions, as well as ideas for improvement. Country coordinators in each context were mediators for knowledge-co-creation between all partners involved. Transferability researchers guided the process and analysed the results of discussions through workshops, interviews and focus groups.

Conclusions
Establishing trust between partners was a key issue in all contexts. Participatory transferability analysis required the consideration of a complex interplay between understanding content of interventions, context, and the specific characteristics and contributions of stakeholders.
Pandemic-time mental health surveillance among the French population using survey and routine data
Authors: du Roscoät E , Forgeot C 
Published: October 2023

Abstract
Alerted by the scientific community about a possible negative impact of the COVID-19 epidemic on population's mental health, Santé publique France (the French public health agency) started a reactive surveillance in March 2020. From a crisis management perspective, the objective was to closely monitor mental health developments during the pandemic and to collect necessary information to implement preventive and protective interventions for the population. The population mental health surveillance was mainly based on two data sources: first, the Coviprev survey, a declarative internet-based survey among the adult population ran weekly and then monthly during the pandemic, and second, the OSCOUR® database, developed after the heat wave of summer 2003 in France, which has been collecting daily emergency department (ED) data for almost 20 years. 94% of French ED visits are collected by the system. The main indicators monitored were mood disorders, anxiety disorders, suicidal ideation and behaviors. This surveillance confirmed, from the start and throughout the epidemic, the negative impact of the health crisis on the population's mental health and suggested that adolescents (aged 11 to 17 years) and young adults (aged 18 to 24 years) have been more affected than the rest of the population. In comparison to previous years, significant increases of mood disorders and suicidal behaviors were observed in both data sources in the beginning of 2021 and are still observed in 2023 for some indicators. The results of the work carried out showed the importance of a continuous surveillance of mental health during a crisis situation based on reactive data sources which are essential tools for steering preventive responses and advocating for the strengthening of mental health prevention and promotion policies. Strengths and limitations of the implemented surveillance system integrating two different data sources will be discussed.