bluuebunny/crossref_metadata_2025_split huggingface dataset:
Heidegger’s Answer to Plato’s Parmenides
Authors: Thatcher Michael 
Published: October 2023

AbstractPlato’s dialogue Parmenides remains one of—if not, the—most perplexing text in the Platonic corpus. Specifically, it examines the difficulties surrounding the concepts of unity, multiplicity, and Being that are required for participation in the Ideas. One of the problems forced upon the young Socrates by Parmenides and Zeno in the second half of the dialogue concerns the relationship between Being (ὄν) and the One (ἕν), namely, how defensible is the oneness, or the unity, of the Idea if it also partakes of Being? The text culminates in an aporia as to how to articulate the difference between the One (ἕν) and the many (πολλά), since if the one is, it becomes many. How do many beings share in the one mode of Being? Crucially, how are we to articulate the difference between the One and the many, or Being and beings? Where Plato’s answer invoking the enigmatic concept ‘exaiphnēs’ (ἐξαίφνης), the temporal becoming of the unity and plurality of the One, seems to contradict the privileging of presence that Heidegger charges him with, he nonetheless fails to offer an understanding of difference that has neither Being nor unity. I argue that Heidegger’s engagement with the problem of the ontological difference, and its development into the identification of Being with difference itself, offers solutions to this aporia in Plato’s Parmenides by addressing a difference that is irreducible to the one or the many, the relational or the derivative. This has significant consequences for understanding Heidegger’s critique of Plato as not just consisting of the privileging of presence but also the failure to respond to the problem of difference.
Role of Inflammatory Processes in the Brain-Body Relationship Underlying Hypertension
Authors: Carnevale Daniela 
Published: October 2023

Abstract
Purpose of Review
Essential hypertension is a huge health problem that significantly impacts worldwide population in terms of morbidity and mortality. Idiopathic in its nature, elevated blood pressure results from a complex interaction between polygenic components and environmental and lifestyle factors. The constant growth in the burden of hypertension is at odds with expectations, considering the availability of therapeutic strategies. Hence, there is an endless need to further investigate the complexity of factors contributing to blood pressure elevation.

Recent Findings
Recent data indicate that bidirectional interactions between the nervous system and the immune system alter inflammation in the brain and periphery, contributing to chronic hypertension. These findings indicate that the nervous system is both a direct driver of hypertension and also a target of feedback that often elevates blood pressure further. Similarly, the immune system is both target and driver of the blood pressure increases. The contributions of the feedback loops among these systems appear to play an important role in hypertension.

Summary
Together, recent mechanistic studies strongly suggest that the interactions among the brain, immune system, and inflammation affect the participation of each system in the pathogenesis of hypertension, and thus, all of these systems must be considered in concert to gain a full appreciation of the development and potential treatments of hypertension.
BEYOND 2 years: durability of metabolic benefits by simplification of complex insulin regimens in type 2 diabetes
Authors: Giugliano Dario , Longo Miriam , Scappaticcio Lorenzo , Caruso Paola , Gicchino Maurizio , Petrizzo Michela , Bellastella Giuseppe , Maiorino Maria Ida , Esposito Katherine 
Published: October 2023

Abstract
Purpose
To assess the magnitude and durability of the metabolic benefits by simplification of complex insulin treatments in patients with type 2 diabetes inadequately controlled by a full basal-bolus insulin regimen. Herein we report the results of the scheduled 2-year extension of the BEYOND trial.

Methods
Originally, 305 participants with inadequate glycemic control (HbA1c > 7.5%) were randomly assigned to intensification of basal-bolus insulin regimen (n = 101), to a fixed-ratio combination (basal insulin + GLP-1RA, n = 102), or to an association of basal insulin plus an SGLT-2 inhibitor (gliflo-combo, n = 102). The primary efficacy outcome was change from baseline in HbA1c at 24 months assessed by an intention-to-treat analysis. A per-protocol analysis was also performed.

Results
Fifty-five percent of patients completed the study in the two comparison arms. Compared with patients randomized to basal-bolus, patients of the other groups experienced non statistically different reductions in HbA1c level according to either an intention-to-treat analysis (−0.8 ± 1.1%, −0.7 ± 1.1%, and −1.3 ± 1.1%, mean ± SD, fixed-ratio, gliflo-combo and basal bolus, respectively) or per-protocol analysis (−1.2 ± 1.0%, −1.2 ± 1.1%, and −1.3 ± 1.0%, respectively). The final HbA1c level (per protocol) was 7.2 ± 0.8%, 7.3 ± 0.9%, and 7.5 ± 0.9%, respectively (P = NS). Treatment satisfaction (DTSQ) increased in both exchange groups, whereas the proportion of patients with hypoglycemia was lower.

Conclusion
Simplification of complex insulin regimen may be a durable option in at least one-half of patients with type 2 diabetes.

Clinical trial registration
Clinical trial registration no. NCT04196231, clinicaltrials.gov.
Unleashing the digital building bricks
Authors: Muschkiet Michel , Wulfert Tobias , Woroch Robert , Strobel Gero , Banh Leonardo 
Published: October 2023

AbstractThe increasing online competition, associated changes in customer behaviors, and effects of the pandemic in recent years have led to increasing retail store closures. This development has given rise to a downward spiral in terms of a decreasing attractiveness of local shopping places and a further reduction of stores. Research has recognized that smart services can unleash the potential to compensate for the competitive disadvantages of physical retailers by combining tailored physical and digital offerings to enhance customer-oriented value creation. However, most approaches are limited to in-store services without addressing the wider shopping experience in retail surroundings. Therefore, this paper provides a classification framework for smart services in retail evaluated against 163 use cases, as well as six service archetypes. This work contributes to understanding relevant service design elements and proposes applying the idea of a holistic customer experience to service design in physical retail environments.
Preliminary results from the EMoLung clinical study showing early lung cancer detection by the LC score
Authors: Rubio Karla , Müller Jason M. , Mehta Aditi , Watermann Iris , Olchers Till , Koch Ina , Wessels Sabine , Schneider Marc A. , Araujo-Ramos Tania , Singh Indrabahadur , Kugler Christian , Stoleriu Mircea Gabriel , Kriegsmann Mark , Eichhorn Martin , Muley Thomas , Merkel Olivia M. , Braun Thomas , Ammerpohl Ole , Reck Martin , Tresch Achim , Barreto Guillermo 
Published: October 2023

Abstract
Background
Lung cancer (LC) causes more deaths worldwide than any other cancer type. Despite advances in therapeutic strategies, the fatality rate of LC cases remains high (95%) since the majority of patients are diagnosed at late stages when patient prognosis is poor. Analysis of the International Association for the Study of Lung Cancer (IASLC) database indicates that early diagnosis is significantly associated with favorable outcome. However, since symptoms of LC at early stages are unspecific and resemble those of benign pathologies, current diagnostic approaches are mostly initiated at advanced LC stages.

Methods
We developed a LC diagnosis test based on the analysis of distinct RNA isoforms expressed from the GATA6 and NKX2-1 gene loci, which are detected in exhaled breath condensates (EBCs). Levels of these transcript isoforms in EBCs were combined to calculate a diagnostic score (the LC score). In the present study, we aimed to confirm the applicability of the LC score for the diagnosis of early stage LC under clinical settings. Thus, we evaluated EBCs from patients with early stage, resectable non-small cell lung cancer (NSCLC), who were prospectively enrolled in the EMoLung study at three sites in Germany.

Results
LC score-based classification of EBCs confirmed its performance under clinical conditions, achieving a sensitivity of 95.7%, 91.3% and 84.6% for LC detection at stages I, II and III, respectively.

Conclusions
The LC score is an accurate and non-invasive option for early LC diagnosis and a valuable complement to LC screening procedures based on computed tomography.
A novel computer modeling and simulation technique for bronchi motion tracking in human lungs under respiration
Authors: Kim Byeong-Jun , Ahn Hyo Yeong , Song Chanhee , Ryu Dongman , Goh Tae Sik , Lee Jung Sub , Lee Chiseung 
Published: October 2023

AbstractIn this work, we proposed a novel computer modeling and simulation technique for motion tracking of lung bronchi (or tumors) under respiration using 9 cases of computed tomography (CT)-based patient-specific finite element (FE) models and Ogden’s hyperelastic model. In the fabrication of patient-specific FE models for the respiratory system, various organs such as the mediastinum, diaphragm, and thorax that could affect the lung motions during breathing were considered. To describe the nonlinear material behavior of lung parenchyma, the comparative simulation for biaxial tension-compression of lung parenchyma was carried out using several hyperelastic models in ABAQUS, and then, Ogden’s model was adopted as an optimal model. Based on the aforementioned FE models and Ogden’s material model, the 9 cases of respiration simulation were carried out from exhalation to inhalation, and the motion of lung bronchi (or tumors) was tracked. In addition, the changes in lung volume, lung cross-sectional area on the axial plane during breathing were calculated. Finally, the simulation results were quantitatively compared to the inhalation/exhalation CT images of 9 subjects to validate the proposed technique. Through the simulation, it was confirmed that the average relative errors of simulation to clinical data regarding to the displacement of 258 landmarks in the lung bronchi branches of total subjects were 1.10%~2.67%. In addition, the average relative errors of those with respect to the lung cross-sectional area changes and the volume changes in the superior-inferior direction were 0.20%~5.00% and 1.29 ~ 9.23%, respectively. Hence, it was considered that the simulation results were coincided well with the clinical data. The novelty of the present study is as follows: (1) The framework from fabrication of the human respiratory system to validation of the bronchi motion tracking is provided step by step. (2) The comparative simulation study for nonlinear material behavior of lung parenchyma was carried out to describe the realistic lung motion. (3) Various organs surrounding the lung parenchyma and restricting its motion were considered in respiration simulation. (4) The simulation results such as landmark displacement, lung cross-sectional area/volume changes were quantitatively compared to the clinical data of 9 subjects.
Determining homology of an unknown space from a sample
Authors: Brun Morten , García Pascual Belén , Salbu Lars M. 
Published: October 2023

AbstractThe homology of an unknown subspace of Euclidean space can be determined from the intrinsic Čech complex of a sample of points in the subspace, without reference to the ambient Euclidean space. More precisely, given a subspace X of Euclidean space and a sample A of points in X, we give conditions for the homology of X to be isomorphic to a certain persistent homology group of the intrinsic Čech complex.
Mapping AI avant-gardes in time: posthumanism, transhumanism, genhumanism
Authors: Brusseau James 
Published: October 2023

AbstractThree directions for the AI avant-garde are sketched against the background of time. Posthumanism changes what we are, and belongs to the radical future. Transhumanism changes how we are, and corresponds with the radical past. Genhumanism changes who we are, and exists in the radical present. While developing the concepts, this essay intersects in two ways with theoretical debates about humanism in the face of technological advance. First, it describes how temporal divisions may cleanly differentiate post- and transhumanism. Second, the essay introduces generative humanism, which contributes to discussions about AI and society by delineating a novel humanistic response to contemporary technology. Finally, grounds are provided for a practical project, one where philosophers work with AI engineers in the area of genhumanism. Contemporary AI research into serendipity in recommendation engines provides natural support for the shared research.
A critical review of status quo and future directions of owner dynamic capabilities: Dimensions and key factors
Authors: Tian Zidan , Wang Ting , He Qinghua 
Published: October 2023

Abstract
Existing studies agree that owner dynamic capabilities are crucial in dynamic environments. Based on a systematic literature review of 44 research with CiteSpace and the content analysis method, this study aims to elucidate the dimensions and key factors of owner dynamic capabilities. Owner dynamic capabilities are studied in the context of a construction project due to their resource-constrained, goal-urgent, and uncertainty characteristics. Cognition capabilities, resilient change management capabilities, integrated organization capabilities, and strategic innovation capabilities are identified as the dimensions. Critical factors have also been analyzed at different levels. This study proposes a discriminatory framework of owner dynamic capabilities that combined organizational ambidexterity and resilience. Moreover, this study contributes to the clarification of the concept of owner dynamic capabilities and the enrichment of their knowledge hierarchy. Practitioners can track the main contradictions that owners are currently facing against the actual situation and seek strategies.
‘Living the last chapter of History’: Anxiety as a force for rewriting history textbooks in Putin's Russia and before
Authors: Kurbak Maria 
Published: October 2023

Abstract
In this article, I examine efforts to rewrite school history in Putin's Russia, efforts whose precedents in Russia can be traced back to the nineteenth century. I explore this process from the perspective of recent scholarship on ‘collective future thinking’ and demonstrate how a particular feeling – anxiety – shaped Russian and Soviet efforts to change history textbooks. I describe those created in Russia, focusing on their future component and the emotional message accompanying them. In contrast to some other countries, where narratives may be revised or replaced by new ones in accordance with the development of societies and political regimes, in Russia, there is evidence that previous narrative templates continue to coexist. The state may privilege one or another narrative primary in response to emotional pressures, and in some cases, this pushes people towards aggression and even death. I argue that anxiety about the future has forced the current Russian regime to initiate a school history rewriting in the midst of the Russia-Ukraine war, allowing the state to use collective memory to convince people to engage in a brutal conflict.
A new record of a white humpback whale (Megaptera novaeangliae) in Papeete, Tahiti
Authors: De Weerdt Joëlle 
Published: October 2023

AbstractA new record of a white humpback whale (Megaptera novaeangliae) was made off Papeete, Tahiti in July 2019. The individual was completely white, except for grey patterns on its body and on the ventral part of the fluke. The presence of different colourations indicates that this individual is not an albino but a leucistic individual. According to field observations, the individual was likely a juvenile or a subadult. It was seen breaching several times and travelled further north of Papeete, where the animal was recaptured off Arue. White individuals are rare and offer unique opportunities to understand whale movement patterns and potential population connectivity among humpback whale populations.
Global Warming Increases Interannual and Multidecadal Variability of Subarctic Atlantic Nutrients and Biological Production in the CESM1‐LE
Authors: Whitt Daniel B. 
Published: October 2023

AbstractEarth system models indicate that the Subarctic Atlantic Ocean ecosystems are uniquely sensitive to global warming. Nutrients, phytoplankton biomass, and phytoplankton production all decline precipitously in global warming scenarios. Superimposed on this forced response is changing internal variability that is not fully understood. Here, a large ensemble of simulations with the Community Earth System Model is used to quantify how global warming affects the interannual and multidecadal variability of phytoplankton production integrated over the Subarctic Atlantic. Surprisingly, it is found that this variability increases non‐monotonically with global warming. The increased variability of production is caused by an elevated volatility of wintertime surface nutrient concentrations, which is a consequence of a rising sensitivity of these nutrients to winter mixing and overturning fluctuations, which overcomes a reduced amplitude of these physical fluctuations with warming. Future work is needed to fully understand how internal climate variability impacts ocean ecosystems in a warming climate.
Light People: Professor Cheng Zhang
Authors: Guo Siqiu 
Published: October 2023

EditorialNanophotonics has emerged as a cutting-edge interdisciplinary research field today. Its primary objective is to leverage the interaction between light and matter at the wavelength and sub-wavelength scales, with the purpose of designing and manufacturing miniaturized, multifunctional, and high-performance optical devices and systems. Professor Cheng Zhang from Huazhong University of Science and Technology has dedicated his career to nanophotonic device research. His work encompasses a wide range of areas, including plasmonic devices, optical metamaterials, and metasurfaces. Through the design of innovative artificial electromagnetic structures and the exploration of emerging nanofabrication techniques, Professor Cheng Zhang has effectively achieved versatile control over various properties of electromagnetic waves, including amplitude, phase, and polarization states. Furthermore, his research extends to the continuous exploration of novel optical phenomena, aimed at realizing high-performance engineering applications. In this edition of Light People, we will take you deep into the world of Professor Cheng Zhang, a young scientist exemplifying the spirit of innovation, relentless improvement, and unwavering pursuit of excellence. You will discover how he has overcome numerous challenges in the realm of nanophotonic research.
Targeting oncogenic microRNAs from the miR-371~373 and miR-302/367 clusters in malignant germ cell tumours causes growth inhibition through cell cycle disruption
Authors: Bailey Shivani , Ferraresso Marta , Alonso-Crisostomo Luz , Ward Dawn , Smith Stephen , Nicholson James C. , Saini Harpreet , Enright Anton J. , Scarpini Cinzia G. , Coleman Nicholas , Murray Matthew J. 
Published: October 2023

AbstractBackgroundMiR-371~373 and miR-302/367 cluster over-expression occurs in all malignant germ cell tumours (GCTs), regardless of age (paediatric/adult), site (gonadal/extragonadal), or subtype [seminoma, yolk sac tumour (YST), embryonal carcinoma (EC)]. Six of eight microRNAs from these clusters contain the seed sequence ‘AAGUGC’, determining mRNA targeting. Here we sought to identify the significance of these observations by targeting these microRNAs functionally.MethodsWe targeted miR-371~373 and/or miR-302/367 clusters in malignant GCT cell lines, using CRISPR-Cas9, gapmer primary miR-302/367 transcript inhibition, and peptide nucleic acid (PNA) or locked nucleic acid (LNA)-DNA inhibition targeting miR-302a-d-3p, and undertook relevant functional assays.ResultsMiR-302/367 cluster microRNAs made the largest contribution to AAGUGC seed abundance in malignant GCT cells, regardless of subtype (seminoma/YST/EC). Following the unsuccessful use of CRISPR-Cas9, gapmer, and PNA systems, LNA-DNA-based targeting resulted in growth inhibition in seminoma and YST cells. This was associated with the de-repression of multiple mRNAs targeted by AAGUGC seed-containing microRNAs, with pathway analysis confirming predominant disruption of Rho-GTPase signalling, vesicle organisation/transport, and cell cycle regulation, findings corroborated in clinical samples. Further LNA-DNA inhibitor studies confirmed direct cell cycle effects, with an increase of cells in G0/G1-phase and a decrease in S-phase.ConclusionTargeting of specific miR-371~373 and miR-302/367 microRNAs in malignant GCTs demonstrated their functional significance, with growth inhibition mediated through cell cycle disruption.
Fabrication and characterization of a novel catalyst based on modified zirconium metal-organic-framework for synthesis of polyhydroquinolines
Authors: Moghadaskhou Fatemeh , Eivazzadeh-Keihan Reza , Sadat Zahra , Tadjarodi Azadeh , Maleki Ali 
Published: October 2023

AbstractA novel catalyst was fabricated in this study based on zirconium MOF modified with pyridine carboxaldehyde in a solvothermal reaction, embedded with cerium. In order to confirm the catalyst structure, various characterization techniques, including FTIR, Far IR, EDX, XRD, TGA, FE-SEM, ICP, and BET analyses, were employed. The results indicated that the UiO-66-Pyca-Ce (III) catalyst had a Langmuir surface area of 501.63 m2/g, a pore volume of 0.28 cm3/g, and a pore size of 2.27 nm. To study catalytic activity, a sequential approach of Knoevenagel condensation and Michael addition was used to synthesize various polyhydroquinoline derivatives. The reaction took place at ambient temperature. The UiO-66-Pyca-Ce (III) catalyst demonstrated high efficacy (90%) and reusability in asymmetric synthesis of polyhydroquinoline derivatives for several reasons, including the possession of three Lewis acid activation functions.
One-dimensional carbon chains encapsulated in hollandite
Authors: Polfus Jonathan M. 
Published: October 2023

AbstractOne-dimensional carbon chains are highly reactive allotropes that are stabilized inside the protective environment of carbon nanotubes. Here we show that carbon chains can be encapsulated in metal oxides containing open structural channels, exemplified by hollandite α-MnO2. The α-MnO2 channels stabilize cumulene chains due to their structural commensurability, whereas the triple bonds in polyyne chains exhibit excessive steric repulsion to the oxide ions bordering the channel. Cumulene exhibits an interaction energy of only 0.065 eV per carbon atom, obtained by first-principles calculations, which is significantly more favorable than for encapsulation in a similarly sized carbon nanotube. Encapsulation of carbon chains is associated with lateral expansion of the α-MnO2 channel and polarization of the manganese and oxygen charge densities adjacent to the chains. Accordingly, the interaction energy is governed by a balance between van der Waals attraction and steric repulsion between the materials.