bluuebunny/crossref_metadata_2025_split huggingface dataset:
A meta-analysis of the therapeutic effect of probiotic intervention in obese or overweight adolescents
Authors: Duan Yuanqing , Wang Lanping , Ma Yan , Ning Lei , Zhang Xinhuan 
Published: January 2024

Background &amp; aimsExisting evidence on the possible effects of probiotics on obese or overweight adolescents has not been fully established. Therefore, the aim of this study was to explore the effects of probiotic supplementation on anthropometric indices, inflammatory markers and metabolic indices in obese or overweight adolescents.MethodsThe literature up to March 2023 related to probiotic intervention in obese or overweight adolescents was searched and screened from multiple databases, including the CNKI(China national knowledge infrastructure), CBM(Chinese biomedical literature database), PubMed, EmBase, and Cochrane library databases. All randomized controlled trials using probiotic supplements in obese or overweight adolescents were included in this systematic review and meta-analysis.ResultsA total of 8 studies that met the inclusion criteria were included in this study. There were 201 cases in the experimental group (probiotic treatment) and 190 cases in the control group. Compared to the control group, probiotic intervention in adolescents resulted in a decrease in body mass index, fasting blood glucose and C-reactive protein with WMD(Weighted mean difference) and 95% CI of -2.53 (-4.8 to -0.26) kg/m2, -0.80 (-1.13 to -0.47) mol/L and -0.24 (-0.43 to -0.05) mg/L, respectively. No significant changes were found in weight, waist circumference, waist-to-hip ratio, insulin, Homeostatic Model Assessment of insulin resistance, interleukin 6, tumor necrosis factor alpha and so on; however, an unfavorable elevated effect in total cholesterol, triglycerides, and low-density lipoproteins was detected with WMD and 95% CI of 0.06 (0.02 to 0.09) mmol/L, 0.18 (0.14 to 0.21) mmol/L, and 0.19 (0.18 to 0.20) mmol/L, respectively.ConclusionAccording to our results, probiotic supplementation was beneficial in managing metabolic indicators such as fasting blood glucose, body mass index and inflammation-related C-reactive protein in overweight or obese adolescents. Further large scale studies are warranted to confirm present findings and to identify the effects and mechanisms to provide more precise evidence for clinical intervention.Systematic review registrationdoi: 10.37766/inplasy2024.1.0081, identifier INPLASY202410081.
Differential age-related transcriptomic analysis of ovarian granulosa cells in Kazakh horses
Authors: Ren Wanlu , Wang Jianwen , Zeng Yaqi , Wang Tongliang , Meng Jun , Yao Xinkui 
Published: January 2024

IntroductionThe Kazakh horse, renowned for its excellence as a breed, exhibits distinctive reproductive traits characterized by early maturity and seasonal estrus. While normal reproductive function is crucial for ensuring the breeding and expansion of the Kazakh horse population, a noteworthy decline in reproductive capabilities is observed after reaching 14 years of age.MethodsIn this study, ovarian granulosa cells (GCs) were meticulously collected from Kazakh horses aged 1, 2, 7, and above 15 years old (excluding 15 years old) for whole transcriptome sequencing.ResultsThe analysis identified and selected differentially expressed mRNAs, lncRNAs, miRNAs, and circRNAs for each age group, followed by a thorough examination through GO enrichment analysis. The study uncovered significant variations in the expression profiles of mRNAs, lncRNAs, miRNAs, and circRNAs within GCs at different stages of maturity. Notably, eca-miR-486-3p and miR-486-y exhibited the highest degree of connectivity. Subsequent GO, KEGG, PPI, and ceRNA network analyses elucidated that the differentially expressed target genes actively participate in signaling pathways associated with cell proliferation, apoptosis, and hormonal regulation. These pathways include but are not limited to the MAPK signaling pathway, Hippo signaling pathway, Wnt signaling pathway, Calcium signaling pathway, Aldosterone synthesis and secretion, Cellular senescence, and NF-kappa B signaling pathway—essentially encompassing signal transduction pathways crucial to reproductive processes.DiscussionThis research significantly contributes to unraveling the molecular mechanisms governing follicular development in Kazakh horses. It establishes and preliminarily validates a differential regulatory network involving lncRNA-miRNA-mRNA, intricately associated with processes such as cell proliferation, differentiation, and apoptosis and integral to the developmental intricacies of stromal follicles. The findings of this study provide a solid theoretical foundation for delving deeper into the realm of reproductive aging in Kazakh mares, presenting itself as a pivotal regulatory pathway in the context of horse ovarian development.
Unveiling rural energy pattern determinants: insights from forest-dwelling rural households in the Zagros Mountains, Iran
Authors: Bazgir Ahmad , Maleknia Rahim , Rahimian Mehdi 
Published: January 2024

IntroductionThis study examines the determinants of energy sources among rural households in the forested regions of the Zagros Mountains in Iran.MethodsThe research focuses on 157 forest villages, categorized into three groups based on their access to different fuel sources: wood, kerosene and liquefied petroleum gas (LPG), and natural gas (NG). A survey was conducted among 346 rural households using a multi-stage stratified random sampling approach and a questionnaire.ResultsThe findings reveal that firewood plays a significant role in household energy patterns, particularly in remote areas. Income is identified as a crucial determinant of energy structure, but non-income socio-economic factors also strongly influence energy patterns. Moreover, commercial energy sources exhibit higher energy efficiency, resulting in reduced annual energy consumption compared to the use of firewood as the primary fuel.DiscussionThe study emphasizes the urgent need to address the reliance on low-efficiency energy sources to mitigate deforestation risks. In countries like Iran, where forest resources are limited, transitioning from firewood to higher efficiency fuels becomes imperative for forest conservation and sustainability. The implications of this research underscore the importance of considering both economic and social dimensions in energy planning and interventions, promoting accessible and affordable alternatives to traditional biomass fuels, and designing targeted policies to encourage the adoption of cleaner and more efficient energy sources in rural areas.
Gut dysbiosis in patients with chronic pain: a systematic review and meta-analysis
Authors: Goudman Lisa , Demuyser Thomas , Pilitsis Julie G. , Billot Maxime , Roulaud Manuel , Rigoard Philippe , Moens Maarten 
Published: January 2024

IntroductionRecent evidence supports the contribution of gut microbiota dysbiosis to the pathophysiology of rheumatic diseases, neuropathic pain, and neurodegenerative disorders. The bidirectional gut-brain communication network and the occurrence of chronic pain both involve contributions of the autonomic nervous system and the hypothalamic pituitary adrenal axis. Nevertheless, the current understanding of the association between gut microbiota and chronic pain is still not clear. Therefore, the aim of this study is to systematically evaluate the existing knowledge about gut microbiota alterations in chronic pain conditions.MethodsFour databases were consulted for this systematic literature review: PubMed, Web of Science, Scopus, and Embase. The Newcastle-Ottawa Scale was used to assess the risk of bias. The study protocol was prospectively registered at the International prospective register of systematic reviews (PROSPERO, CRD42023430115). Alpha-diversity, β-diversity, and relative abundance at different taxonomic levels were summarized qualitatively, and quantitatively if possible.ResultsThe initial database search identified a total of 3544 unique studies, of which 21 studies were eventually included in the systematic review and 11 in the meta-analysis. Decreases in alpha-diversity were revealed in chronic pain patients compared to controls for several metrics: observed species (SMD= -0.201, 95% CI from -0.04 to -0.36, p=0.01), Shannon index (SMD= -0.27, 95% CI from -0.11 to -0.43, p&lt;0.001), and faith phylogenetic diversity (SMD -0.35, 95% CI from -0.08 to -0.61, p=0.01). Inconsistent results were revealed for beta-diversity. A decrease in the relative abundance of the Lachnospiraceae family, genus Faecalibacterium and Roseburia, and species of Faecalibacterium prausnitzii and Odoribacter splanchnicus, as well as an increase in Eggerthella spp., was revealed in chronic pain patients compared to controls.DiscussionIndications for gut microbiota dysbiosis were revealed in chronic pain patients, with non-specific disease alterations of microbes.Systematic review registrationhttps://www.crd.york.ac.uk/prospero/, identifier CRD42023430115.
Areal bone mineral density, trabecular bone score and 3D-DXA analysis of proximal femur in psoriatic disease
Authors: Toussirot Eric , Winzenrieth Renaud , Aubin François , Wendling Daniel , Vauchy Charline , Desmarets Maxime 
Published: January 2024

ObjectivesTo evaluate bone mineral density (BMD) and bone quality, with assessment of the cortical and trabecular compartments, in patients with psoriasis (PsO) alone or with psoriatic arthritis (PsA).MethodsPatients with PsA and patients with PsO alone were evaluated and compared to control subjects matched for age, sex and body mass index category. Areal BMD (aBMD) was determined for the lumbar spine, femoral neck, total hip and total body using dual-energy X-ray absorptiometry (DXA). Bone quality was evaluated by using trabecular bone score (TBS) at the lumbar spine, and by 3D DXA-based analysis (3D Shaper) for the proximal femur.ResultsOne hundred ninety-six subjects including 52 patients with PsA and 52 patients with PsO and their respective paired controls were analyzed. Patients with PsA had comparable aBMD, TBS and 3D DXA analysis parameters compared to their paired controls. After adjustment for confounders, patients with PsO alone were characterized by a higher aBMD at the left femur and higher cortical 3D DXA derived parameters (total hip cortical surface BMD and total hip cortical thickness) than their paired controls. TBS was decreased in PsO compared to their controls.ConclusionPatients with PsA had normal bone mass and bone quality parameters. Patients with PsO were characterized by higher femoral neck bone density by DXA and cortical parameters by 3D DXA-based analysis, supporting no increased risk for hip fracture. Conversely, bone texture by TBS assessment was decreased in patients with PsO, which may be associated with impaired vertebral bone resistance.
Risk stratification for early mortality in newly diagnosed acute promyelocytic leukemia: a multicenter, non-selected, retrospective cohort study
Authors: Kim Suhyeon , Jung Jiye , Ahn Seo-Yeon , Kim Mihee , Jeon So Yeon , Lee Chang-Hoon , Kim Dae Sik , Lee Se Ryeon , Sung Hwa Jung , Choi Chul Won , Kim Byung-Soo , Kim Hyeoung-Joon , Kwak Jae-Yong , Park Yong , Ahn Jae-Sook , Yhim Ho-Young 
Published: January 2024

IntroductionDespite the current effective treatments for acute promyelocytic leukemia (APL), early mortality (EM), defined as death within 30 days of presentation, is a major hurdle to long-term survival.MethodsWe performed a multicenter retrospective study to evaluate the incidence and clinical characteristics of EM in patients with newly diagnosed APL and to develop a risk stratification model to predict EM.ResultsWe identified 313 eligible patients diagnosed between 2000 and 2021 from five academic hospitals. The median age was 50 years (range 19-94), and 250 (79.9%) patients were &lt;65 years. Most patients (n=274, 87.5%) received their first dose of all-trans retinoic acid (ATRA) within 24 hours of presentation. EM occurred in 41 patients, with a cumulative incidence of 13.1%. The most common cause of EM was intracranial hemorrhage (n=22, 53.6%), and most EMs (31/41, 75.6%) occurred within the first seven days of APL presentation. In a multivariable analysis, we identified three independent factors predicting EM: age ≥65 years (HR, 2.56), white blood cell count ≥8.0 x 109/L (HR, 3.30), and ATRA administration &gt;24 hours of presentation (HR, 2.95). Based on these factors, patients were stratified into three categories with a significantly increasing risk of EM: 4.1% for low risk (54.3%; no risk factors; HR 1), 18.5% for intermediate risk (34.5%; 1 factor; HR 4.81), and 40.5% for high risk (11.2%; 2-3 factors; HR 13.16).DiscussionThe risk of EM is still not negligible in this era of ATRA-based therapies. Our risk model serves as a clinically useful tool to identify high-risk patients for EM who may be candidates for novel treatments and aggressive supportive strategies.
Les nouveaux modes d’utilisation des établissements publics
Authors: Heurté André 
Published: January 2024

New ways of using state enterprises
Although modern State enterprise is based on the principle of specialisation, its purpose confers on it a specific geographic role. Moreover, a whole host of links on the organic, financial and staff levels grow up between it and other organisations. In the Bouches du Rhône, Vaucluse and the Alpes departements, State enterprises can be divided into three categories. Most of them were set up on a unilateral basis. Others however are the resuit of a combination of interests. The Port of Fos industrial complex, which is without doubt a unique experiment, consists of a group of State-run industries. Despite the success achieved, it has so far not proved possible to co-ordinate administrative action and the priority given to industrial and commercial interests has entailed a decline in the concern shown for the interests of the population as a whole.
L’économie mixte, procédé d’administration publique dans la région Provence-Alpes-Côte d’Azur
Authors: Prats Yves 
Published: January 2024

The semi-public sector ; public administration procédure in the Provence-Alpes-Cote d’Azur region

The creation of a semi-public enterprise is an administrative procedure which has been used in France since the beginning of the century ; in its broadest form it means that one or more regional public bodies own the public portion of a company’s capital. But one might well ask how long this traditional definition of a semi-public enterprise as meaning joint public and private ownership of the capital is likely to last. In fact, local semi-public companies, which is the favourite System of local authorities for carrying out their development projects, are in practice a means to enable minor communities to combine their operations and, on the rare occasions when private capital is involved, it is generally minimal.
The author directs his attention to a description of the semi-public companies in the Provence-Alpes-Côte d’Azur region, the way in which these were set up and the problems of controlling them. Quoting concrete examples, he describes the use of the semi-public company in the context of the municipality of Marseille and within the context of regional development.
Les sociétés et organismes de droit privé
Authors: Guérin Paul 
Published: January 2024

Las sociedades y organismos de derecho privado
Las sociedades de economía mixta juegan un papel particularmente importante en la Región Provenzal, puesto que dependen de ella no menos que treinta y una. Su repartición geográfica testifica la localización de los centros de desarrollo de la región y es así que la mayor parte de las grandes ciudades de la región (Marsella, Aix, Martigues, Carpentras, etc.), disponen cada una de una sociedad de desarrollo. La mayor parte de estas sociedades son de construcción, pero algunas están también investidas del rol de concesionarias de obras o de servicios públicos, o sirven de marco jurídico en las intervenciones de la administración. Pero la creación de sociedades de economía mixta disimula frecuentemente la centralización de las operaciones, porque ellas ceden su propia gestión a las sociedades de obras nacionales. El fenómeno es particularmente evidente cuando se trata de entrar en participación por parte de organismos de financiamiento de estructura muy centralizada, tales como la Caja de Depósitos y Consignaciones.
Las sociedades de derecho común juegan igualmente un papel importante dentro de la gestión administrativa debiéndose mencionar entre ellas la Sociedad de Equipo y de Unificación de Terrenos que ejerce facultades de poder público, ejercidos o vigilados por dos comisarios del gobierno. Estas sociedades se ocupan con frecuencia del desarrollo del turismo y de la instalación de las aglomeraciones, siendo las más características : la Sociedad de Habitación de Alquiler Moderado de Marsella ; la Sociedad de Desarrollo del Departamento de Hautes-Alpes ; y la Sociedad de la Feria de Marsella. El autor procede a la descripción de sus aspectos lo más originales.
L’évolution du droit de la fonction publique hongroise
Authors: Garancsy Gabriella 
Published: January 2024

The evolution of the right of the civil service in Hungary

Before 1945, the Right of the Civil Service formed an integral part of the administrative Right and assured the civil servants considerable advantages compared to private employees.
After a period of transition, the Work Code of 1950 standardized the rules applicable to all workers. Since the new Work Code was adopted in 1968, only questions of principles, fundamental rights and obligations of workers were codified in an unique text, the special rules applicable to civil servants being fixed by ministerial decree.
The conditions of entry, the level of qualification of the workers, their obligations as well as the termination of their service are thus the object of specific provisions applicable either as a consideration of the employing administration or as a consideration of the level of their functions.
Contrôle de gestion et organisations publiques
Authors: Gibert Patrick , Bernard François 
Published: January 2024

Management control and state organizations
The introduction of an actual System of management control within administrative departments can only be envisaged as an attempt to coordinate the existing dissimilar Systems of control. These can be accused of being too meticulous and at the same time inefficient, in part ad-hoc, uncertain and incomplete and allowing too much scope for subjective judgment, yet they cannot be condemned as wholly inappropriate. The only valid solution for a government service is to institute a 3-dimensional System of overall control. The first of these dimensions is one which matches internal control, i.e. the head of an organization’s control of his organization, against some form of external control. The second is the dimension concerned with aspects of efficiency and pertinence. The third is one which starts with a System to monitor compliance with the organization’s objectives and goes on to measure performance against the objectives and standards set by a higher authority — in this case, the State. A government department’s overall System of control needs to be designed with these three dimensions in mind.
Administration et développement : le cas Sud-Coréen
Authors: Chung Sae Wook 
Published: January 2024

Administración y desarrollo — El caso sudcoreano. Los objetivos del desarrollo han de seguir dos etapas : en primer lugar, el desarrollo de la misma administración, en segundo lugar, la administración del desarrollo como etapa de acción. El estudio del ambiente socio-cultural y del sistema político sudcoreano delinea varios factores que influyen más o menos directamente sobre el proceso del desarrollo : autoritarismo, sectarismo, coexistencia de varios sistemas de valores...
La evolución de estructuras se caracteriza por el desarrollo de órganos de planeamiento y el robustecimiento del centralismo. A pesar de todos los esfuerzos hechos, la experiencia reformista no ha logrado una toma en consideración suficiente de los objetivos de desarrollo, ni tampoco de las insuficiencias del aparato administrativo.
Administration locale et système partisan en Égypte
Authors: Mirel Pierre 
Published: January 2024

Local government and the party system in Egypt. After indicating that the 1952 Revolution restored the centralized State and a concentration of powers, the author States that the new rulers of Egypt can but rely on the former State apparatus when it comes to transforming society — social laws, land reforms, planning, social measures. That is why the history of local government is equivalent to a permanent clash with the one party System. Set up in 1960, the System subordinates local government to the national Union and, thereafter, to the Arabic Socialist Union, for the political power attempts to control the executive power at ail levels.
But the System, which is blocked by the omnipresence of the party and overlapping competencies among administrative bodies, has given rise to a “new class” in a context of bureaucracy and of “State capitalism”. And the structural reform of governorates in 1971, following the party reform of 1968, has but contributed to strengthening administration since “local parliamentarism” does not work in favour of The Party. After the “economic opening”, the “new class” looked after its consecration by the 1975 reform of local administration. Presented as a new step to democratization in Egypt, — local councils are elected through direct universal suffrage — this important reform mainly translates into reality, according to the author, the waning of The Party, the acknowledgement of local governments economic and social role, the predominance of the governor, and finally, the victory of local government over the Party.
Obstacles, contraintes et résistances à la réforme administrative
Authors: Dunsire Andrew 
Published: January 2024

The administrative reform : obstacles, constraints and general resistance

While assessing the obstacles to administrative reform, the author brings them down to two main categories : constraints and general resistance. Apart from this overall distinction, he adds another one between behavioural problems and structural problems. Hence constraints may just like general resistance be due to either behavioural or structural problems. The author applies this distinction to different types of obstacles which administrative reforms have to cope with, i.e. political, economie, social, organizational, and psychological obstacles. Economic obstacles to reform are mainly structural constraints. Psychological obstacles are rather behavioural constraints. Political obstacles result from structural resistance. Social obstacles are due to behavioural resistance.
The conclusion that can be drawn from this analysis is that administrative reform has to watch out for the specific types of obstacles and allow for constraints and resistance arising from structure or attitudes. A reformer has to resemble a helmsman who knows how to assess the type, variety and size of obstacles to cope with ; he sets the targets and fixes the ways and means of reform which he negotiates along the lines of least resistance.
La participation à la gestion des affaires publiques : les communautés rurales sénégalaises
Authors: Ndiaye Birame 
Published: January 2024

La participación en los asuntos públicos : las comunidades rurales senegaleses

El artículo trata de la reforma de 1972 modificando substancialmente la organización territorial senegalesa.
La reforma abre la decentralización territorial a toda la nación, es decir a los 70 por cien de la populación que hasta entonces no estaban visados, y fortalece por diversificación la participación de los rurales en la gestión de los asuntos públicos. Visto las dificuldades que encuentran las poblaciones visadas para mantener el funcionamiento de una colectividad efectivamente decentralizada, había la nueva organizatión de adoptar un procedimiento de semi-decentralización con la comunidad rural como instrumento institucional.