bluuebunny/crossref_metadata_2025_split huggingface dataset:
Holding on to life: COVID-19 pandemic impact, adaptation and resilience in Abeokuta, Nigeria
Authors: Odunsi Oluwafemi Michael , Ayedun Henry Oluwaseyi , Odunsi Margaret Yejide , Momodu Surajudeen Oluseyi , Badiora Adewumi Israel , Taiwo Amos Oluwole , Adebara Temitope Muyiwa 
Published: January 2024

AbstractThe COVID-19 posed severe public health effects across the world to an extent that it was declared a pandemic. Aside the health effects are other consequences associated with measures such as lockdown, isolation and physical distancing to curb the spread of the virus. This study assesses the impact of the pandemic on households and their adaptation across different residential density zones in Abeokuta, Nigeria, with a novelty of understanding its socio-spatial context. This study utilised a quantitative research design based on a cross-sectional survey for the phases of data collection, analysis and interpretation. A two-stage sampling technique was employed in selecting 422 participants for the study. All participants were administered questionnaire and 391 copies were considered during data analysis. The data were analysed using cross-tabulation and the hypotheses tested using ANOVA. Findings on socioeconomic characteristics showed that the distribution of respondents descriptively varied across the high, medi residential density zones. Evidence of significant variances in the impact of COVID-19 pandemic on households ([F (2, 388) = 30.406, p = 0.000]) and their adaptation strategies ([F (2, 388) = 39.539, p = 0.000]) were established across residential zones in Abeokuta. The practical implication provides for policymakers and stakeholders to design targeted interventions and support measures for households. The theoretical implication is about contributing to the existing body of knowledge on the impact of pandemics on households by establishing a socio-spatial context and highlighting the need for socioeconomic context-specific responses.
Networked Bollywood
Authors: Rai Swapnil 
Published: January 2024

Networked Bollywood provides interdisciplinary analysis of the role of the stars in the transformation of Hindi cinema into a global entertainment industry. The first Indian film was made in 1913. However, filmmaking was recognized as an industry almost a hundred years later. Yet, Indian films have been circulating globally since their inception. This book unearths this oft-elided history of Bollywood's globalization through multilingual, transnational research and discursive cultural analysis. The author illustrates how over the decades, a handful of primarily male megastars, as the heads of the industry's most prominent productions and corporations, combined overwhelming charismatic affect with unparalleled business influence. Through their “star switching power,” theorized here as a deeply gendered phenomenon and manifesting broader social inequalities, India's most prominent stars instigated new flows of cinema, industrial collaborations, structured distinctive business models, influenced state policy and diplomatic exchange, thereby defining the future of Bollywood's globalization.
Coexisting with Drug Addiction: Strategies Used by Hong Kong’s Older Mixed Users to Improve Their Perceived Quality of Life
Authors: Cheng Vincent S. 
Published: January 2024

AbstractIn Hong Kong, the percentage of older drug users has increased over the last two decades. However, the motivations behind their drug-use behaviours have received little research attention. This study focuses on older drug users who are enrolled in methadone treatment programmes but still use illicit drugs (mixed use). Some studies in the criminological literature and government discourse consider drug users to be passive and lacking self-control. However, in-depth interviews in with 25 older mixed users (aged over 50 years) in Hong Kong revealed that mixed use is one of the various strategies they actively employ to improve their self-perceived quality of life. Using the framework of the selective optimization with compensation model, this study (1) describes the strategies older mixed users adopt as active agents to improve their self-perceived quality of life while coexisting with their addiction; and (2) explains how these strategies were affected and constrained by Hong Kong’s prohibitionist drug policy. I infer that prohibitionist drug policies that emphasize on total drug abstinence may fail to cater to the needs of older drug users who have undergone several relapses and treatments in their lifetimes and do not think they can give up using drugs. This study also provides evidence to show how some drug users may act as active agents to manage and coexist with their addiction, and their agency seems to be constrained by the wider drug policy implemented in Hong Kong.
In Cervisia Veritas: The impact of repealing Sunday blue laws on alcohol sales and retail competition
Authors: Connolly Cristina , Graziano Marcello , McDonnell Alyssa , Steinbach Sandro 
Published: January 2024

AbstractThis study examines the impact of repealing Sunday blue laws on alcohol sales and retail competition, focusing on Connecticut’s 2012 policy change allowing Sunday beer sales in grocery stores. Using nationwide data from 2004 to 2021, we find a short-term increase in beer sales post-policy change, but no significant long-term economic effects on grocery and liquor stores. Our analysis also shows similar treatment effects for chain and standalone liquor retailers, suggesting limited lasting implications for the liquor retail industry’s performance and conduct after Sunday sale restrictions were lifted.
VATICANVS GRAECVS 156, CASSIUS DIO AND THELVDI SAECVLARESOFa.d.204
Authors: Mallan C.T. 
Published: January 2024

AbstractA scholium in codex Vaticanus graecus 156 provides evidence that Cassius Dio'sRoman Historyonce contained an explicit reference to theludi saecularesofa.d. 204, something that has been denied in recent scholarship.
The anatomy of government bond yields synchronization in the Eurozone
Authors: Barbieri Claudio , Guerini Mattia , Napoletano Mauro 
Published: January 2024

AbstractWe investigate the synchronization of the Eurozone’s government bond yields at different maturities. For this purpose, we combine principal component analysis with random matrix theory. We find that synchronization depends on yield maturity. Short-term yields are not synchronized. Medium- and long-term yields, instead, were highly synchronized early after the introduction of the Euro. Synchronization then decreased significantly during the Great Recession and the European Debt Crisis, to partially recover after 2015. We interpret our empirical results using portfolio theory, and we point to divergence trades as a source of the self-sustained yield asynchronous dynamics. Our results envisage synchronization as a requirement for the smooth transmission of conventional monetary policy in the Eurozone.
Epidemic modelling and actuarial applications for pandemic insurance: a case study of Victoria, Australia
Authors: Zhai Chang , Chen Ping , Jin Zhuo , Siu Tak Kuen 
Published: January 2024

AbstractWith the recent outbreak of COVID-19, evaluating the epidemic risk appears to be a pressing issue of global concern and one of the major challenges recently. In the fight against pandemics, the ability to understand, model, and forecast the transmission dynamics of infectious diseases plays a crucial role. This paper provides an overview of foundational compartment models and introduces the Susceptible-Exposed-Infected-Containing-3-Substates-Recovered-Dead model to study the dynamics of COVID-19. A meticulous data calibration procedure is employed to study the evolution trend of an actual pandemic using real-world data from Victoria, Australia. Additionally, the paper discusses innovative applications of epidemic models to the insurance industry, which are currently under investigation. Through the use of the newly developed analytically tractable model, insurance companies are able to determine fair premium levels during an outbreak. Moreover, the paper provides practical guidance for insurance companies by examining the variation in reserve levels over time.
Associations of offspring birthweight and placental weight with subsequent parental coronary heart disease: survival regression using the walker cohort
Authors: Sánchez-Soriano Carlos , Pearson Ewan R. , Reynolds Rebecca M. 
Published: January 2024

AbstractLow birth weight (BW) is consistently correlated with increased parental risk of subsequent cardiovascular disease, but the links with offspring placental weight (PW) are mostly unexplored. We have investigated the associations between parental coronary heart disease (CHD) and offspring BW and PW using the Walker cohort, a collection of 48,000 birth records from Dundee, Scotland, from the 1950s and 1960s. We linked the medical history of 13,866 mothers and 8,092 fathers to their offspring’s records and performed Cox survival analyses modelling maternal and paternal CHD risk by their offspring’s BW, PW, and the ratio between both measurements. We identified negative associations between offspring BW and both maternal (hazard ratio [HR]: 0.91, 95% confidence interval [CI]: 0.88–0.95) and paternal (HR: 0.96, 95% CI: 0.93–1.00) CHD risk, the stronger maternal correlation being consistent with previous reports. Offspring PW to BW ratio was positively associated with maternal CHD risk (HR: 1.14, 95% CI: 1.08–1.21), but the associations with paternal CHD were not significant. These analyses provide additional evidence for intergenerational associations between early growth and parental disease, identifying directionally opposed correlations of maternal CHD with offspring BW and PW, and highlight the importance of the placenta as a determinant of early development and adult disease.
Enhanced Drought Exposure Increasingly Threatens More Forests Than Observed
Authors: Xu Chongyang , Liu Hongyan , Ciais Philippe , Hartmann Henrik , Camarero Jesús J. , Wu Xiuchen , Hammond William M. , Allen Craig D. , Chen Fahu 
Published: January 2024

AbstractForest protection and afforestation have been identified as a means to partially offset anthropogenic CO2 emissions. Yet, increasingly frequent observations of drought‐induced tree mortality are reported. Here, we applied a risk analysis framework for global drought‐induced forest mortality by examining extreme reductions in greenness and water content of forest canopies during past mortality events as well as growth recovery of surviving individual trees following stand‐scale mortality events. We defined a drought‐induced mortality risk index (DMR) that explains 80% of documented tree mortality. Rising CO2 alleviated the increase of DMR with short‐term drought, however, the observed DMR increases with long‐term drought no matter whether considering plant responses to CO2. DMR in sites where tree mortality has been observed significantly increased since the 1980s. More than that, drought exposure threatened 0.28 billion hectares of forested areas. Our framework highlights how climate change‐induced drought, especially hotter‐droughts, threatens the sustainability of global forests.
Dynamic Rupture of the 2021 MW 7.4 Maduo Earthquake: An Intra‐Block Event Controlled by Fault Geometry
Authors: Wen Yangmao , Cai Jianfeng , He Kefeng , Xu Caijun 
Published: January 2024

AbstractThe 2021 MW 7.4 Maduo event occurred within the Bayan Har block in eastern Tibet, which provides an opportunity to investigate the stress conditions and rheology of faults within the block. Here, we perform dynamic rupture simulations based on the finite element method to explore the physical conditions underlying this earthquake and the factors that controlled the rupture process. We construct the model with a nonplanar fault inferred from the Interferometric Synthetic Aperture Radar (InSAR) data and aftershocks sequence relocation. Our dynamic model is controlled by slip‐weakening friction law with initial stress on fault resolved from a uniform regional stress field. The preferred model produces an average slip of ∼2.2 m with a maximum slip of ∼4.0 m. There are three asperities distributed along the strike, which have captured the main features of the Maduo event. The simulation results are consistent with the static GPS coseismic surface displacements, InSAR data, and displacement waveforms recorded by high‐rate GNSS stations. By comparing the results with the planar fault model and rotated stress fields, we find that the fault geometry and regional stress field are the primary factors that control the rupture process of the event. Moreover, we infer that the unfavorable orientation and fault bend lead to minor slips on the branch fault. Furthermore, we investigate the potential mechanisms of supershear rupture on the eastern fault segment.
Contemporary definitions of infant growth failure and neurodevelopmental and behavioral outcomes in extremely premature infants at two years of age
Authors: Strobel Katie M. , Wood Thomas R. , Valentine Gregory C. , German Kendell R. , Gogcu Semsa , Hendrixson D. Taylor , Kolnik Sarah E. , Law Janessa B. , Mayock Dennis E. , Comstock Bryan A. , Heagerty Patrick J. , Juul Sandra E. 
Published: January 2024

Abstract
Background
Associations of 2-year neurodevelopmental and behavioral outcomes with growth trajectories of preterm infants are unknown.

Methods
This secondary analysis of a preterm cohort examined in-hospital and discharge to 2-year changes in anthropometric z-scores. Two-year follow-up included Bayley Scales of Infant Development (BSID-III) and Child Behavior Checklist.

Results
Among 590 infants, adjusted in-hospital growth was not associated with any BSID-III subscale. Occipitofrontal circumference (OFC) growth failure (GF) in-hospital was associated with increased adjusted odds of attention problems (aOR 1.65 [1.03, 2.65]), aggressive behavior (aOR 2.34 [1.12, 4.89]), and attention-deficit-hyperactivity symptoms (aOR 1.86 [1.05, 3.30]). Infants with OFC GF at 2 years had lower adjusted BSID-III language scores (−4.0 [−8.0, −0.1]), increased odds of attention problems (aOR 2.29 [1.11, 4.74]), aggressive behavior (aOR 3.09 [1.00, 9.56]), and externalizing problems (aOR 3.01 [1.07, 8.45]) compared to normal OFC growth cohort.

Conclusion
Infants with OFC GF are at risk for neurodevelopmental and behavioral impairment.

Clinical trial registration
This study is a secondary analysis of pre-existing data from the PENUT Trial Registration: NCT01378273.
Targeting ZDHHC21/FASN axis for the treatment of diffuse large B-cell lymphoma
Authors: Liu Bangdong , Zhao Xianlan , Zhang Shihao , Li Qiong , Li Xinlei , Huang Dezhi , Xia Jing , Ma Naya , Duan Yishuo , Zhang Xi , Rao Jun 
Published: January 2024

AbstractS-palmitoylation is essential for cancer development via regulating protein stability, function and subcellular location, yet the roles S-palmitoylation plays in diffuse large B-cell lymphoma (DLBCL) progression remain enigmatic. In this study, we uncovered a novel function of the palmitoyltransferase ZDHHC21 as a tumor suppressor in DLBCL and identified ZDHHC21 as a key regulator of fatty acid synthetase (FASN) S-palmitoylation for the first time. Specifically, ZDHHC21 was downregulated in DLBCL, and its expression level was associated with the clinical prognosis of patients with DLBCL. In vitro and in vivo experiments suggested that ZDHHC21 suppressed DLBCL cell proliferation. Mechanistically, ZDHHC21 interacted with FASN and mediated its palmitoylation at Cys1317, resulting in a decrease in FASN protein stability and fatty acid synthesis, consequently leading to the inhibition of DLBCL cell growth. Of note, an FDA-approved small-molecule compound lanatoside C interacted with ZDHHC21, increased ZDHHC21 protein stability and decreased FASN expression, which contributed to the suppression of DLBCL growth in vitro and in vivo. Our results demonstrate that ZDHHC21 strongly represses DLBCL cell proliferation by mediating FASN palmitoylation, and suggest that targeting ZDHHC21/FASN axis is a potential therapeutic strategy against DLBCL.
Serum neurofilament indicates accelerated neurodegeneration and predicts mortality in late-stage Parkinson’s disease
Authors: Frank Anika , Bendig Jonas , Schnalke Nils , Klingelhoefer Lisa , Reichmann Heinz , Akgün Katja , Ziemssen Tjalf , Falkenburger Björn H. 
Published: January 2024

AbstractDifferent stages of Parkinson’s disease (PD) are defined by clinical criteria, while late-stage PD is marked by the onset of morbidity milestones and rapid clinical deterioration. Based on neuropathological evidence, degeneration in the dopaminergic system occurs primarily in the early stage of PD, raising the question of what drives disease progression in late-stage PD. This study aimed to investigate whether late-stage PD is associated with increased neurodegeneration dynamics rather than functional decompensation using the blood-based biomarker serum neurofilament light chain (sNfL) as a proxy for the rate of neurodegeneration. The study included 118 patients with PD in the transition and late-stage (minimum disease duration 5 years, mean (SD) disease duration 15 (±7) years). The presence of clinical milestones (hallucinations, dementia, recurrent falls, and admission to a nursing home) and mortality were determined based on chart review. We found that sNfL was higher in patients who presented with at least one clinical milestone and increased with a higher number of milestones (Spearman’s ρ = 0.66, p < 0.001). Above a cutoff value of 26.9 pg/ml, death was 13.6 times more likely during the follow-up period (95% CI: 3.53–52.3, p < 0.001), corresponding to a sensitivity of 85.0% and a specificity of 85.7% (AUC 0.91, 95% CI: 0.85–0.97). Similar values were obtained when using an age-adjusted cutoff percentile of 90% for sNfL. Our findings suggest that the rate of ongoing neurodegeneration is higher in advanced PD (as defined by the presence of morbidity milestones) than in earlier disease stages. A better understanding of the biological basis of stage-dependent neurodegeneration may facilitate the development of neuroprotective means.
Different risks of early-onset and late-onset Parkinson disease in individuals with mental illness
Authors: Yoon Seo Yeon , Lee Sang Chul , Suh Jee Hyun , Yang Seung Nam , Han Kyungdo , Kim Yong Wook 
Published: January 2024

AbstractWe aimed to investigate the association of various mental illnesses, including depression, bipolar disorder, schizophrenia, insomnia, and anxiety, with the risk of early-onset Parkinson’s disease (EOPD) (age <50 years) and compare it with that of late-onset PD (LOPD) (age ≥50 years). This nationwide cohort study enrolled 9,920,522 people who underwent a national health screening examination in 2009, and followed up until 31 December 2018. There was a significantly increased risk of EOPD and LOPD in individuals with mental illness, and EOPD showed a stronger association than LOPD (EOPD, hazard ratio (HR) = 3.11, 95% CI: 2.61‒3.72; LOPD, HR = 1.70, 95% CI: 1.66‒1.74; p for interaction <0.0001). Our results suggest that people with mental illnesses aged < 50 years are at a higher risk of PD than those aged ≥50 years. Future studies are warranted to elucidate the pathomechanism of EOPD in relation to mental illness.
Computational prediction and experimental validation identify functionally conserved lncRNAs from zebrafish to human
Authors: Huang Wenze , Xiong Tuanlin , Zhao Yuting , Heng Jian , Han Ge , Wang Pengfei , Zhao Zhihua , Shi Ming , Li Juan , Wang Jiazhen , Wu Yixia , Liu Feng , Xi Jianzhong Jeff , Wang Yangming , Zhang Qiangfeng Cliff 
Published: January 2024

AbstractFunctional studies of long noncoding RNAs (lncRNAs) have been hindered by the lack of methods to assess their evolution. Here we present lncRNA Homology Explorer (lncHOME), a computational pipeline that identifies a unique class of long noncoding RNAs (lncRNAs) with conserved genomic locations and patterns of RNA-binding protein (RBP) binding sites (coPARSE-lncRNAs). Remarkably, several hundred human coPARSE-lncRNAs can be evolutionarily traced to zebrafish. Using CRISPR–Cas12a knockout and rescue assays, we found that knocking out many human coPARSE-lncRNAs led to cell proliferation defects, which were subsequently rescued by predicted zebrafish homologs. Knocking down coPARSE-lncRNAs in zebrafish embryos caused severe developmental delays that were rescued by human homologs. Furthermore, we verified that human, mouse and zebrafish coPARSE-lncRNA homologs tend to bind similar RBPs with their conserved functions relying on specific RBP-binding sites. Overall, our study demonstrates a comprehensive approach for studying the functional conservation of lncRNAs and implicates numerous lncRNAs in regulating vertebrate physiology.
Lymph-node-targeted, mKRAS-specific amphiphile vaccine in pancreatic and colorectal cancer: the phase 1 AMPLIFY-201 trial
Authors: Pant Shubham , Wainberg Zev A. , Weekes Colin D. , Furqan Muhammad , Kasi Pashtoon M. , Devoe Craig E. , Leal Alexis D. , Chung Vincent , Basturk Olca , VanWyk Haley , Tavares Amy M. , Seenappa Lochana M. , Perry James R. , Kheoh Thian , McNeil Lisa K. , Welkowsky Esther , DeMuth Peter C. , Haqq Christopher M. , O’Reilly Eileen M. 
Published: January 2024

AbstractPancreatic and colorectal cancers are often KRAS mutated and are incurable when tumor DNA or protein persists or recurs after curative intent therapy. Cancer vaccine ELI-002 2P enhances lymph node delivery and immune response using amphiphile (Amph) modification of G12D and G12R mutant KRAS (mKRAS) peptides (Amph-Peptides-2P) together with CpG oligonucleotide adjuvant (Amph-CpG-7909). We treated 25 patients (20 pancreatic and five colorectal) who were positive for minimal residual mKRAS disease (ctDNA and/or serum tumor antigen) after locoregional treatment in a phase 1 study of fixed-dose Amph-Peptides-2P and ascending-dose Amph-CpG-7909; study enrollment is complete with patient follow-up ongoing. Primary endpoints included safety and recommended phase 2 dose (RP2D). The secondary endpoint was tumor biomarker response (longitudinal ctDNA or tumor antigen), with exploratory endpoints including immunogenicity and relapse-free survival (RFS). No dose-limiting toxicities were observed, and the RP2D was 10.0 mg of Amph-CpG-7909. Direct ex vivo mKRAS-specific T cell responses were observed in 21 of 25 patients (84%; 59% both CD4+ and CD8+); tumor biomarker responses were observed in 21 of 25 patients (84%); biomarker clearance was observed in six of 25 patients (24%; three pancreatic and three colorectal); and the median RFS was 16.33 months. Efficacy correlated with T cell responses above or below the median fold increase over baseline (12.75-fold): median tumor biomarker reduction was −76.0% versus −10.2% (P < 0.0014), and the median RFS was not reached versus 4.01 months (hazard ratio = 0.14; P = 0.0167). ELI-002 2P was safe and induced considerable T cell responses in patients with immunotherapy-recalcitrant KRAS-mutated tumors. ClinicalTrials.gov identifier: NCT04853017.