bluuebunny/crossref_metadata_2025_split huggingface dataset:
Analyzing the scale dependent effect of urban building morphology on land surface temperature using random forest algorithm
Authors: Han Weiqun 
Published: November 2023

AbstractWith continuous urban densification, revealing impacts of urban structures on thermal environment is necessary for climate adaptive design. In this study, random forest and partial difference plots were employed to depict the relative importance and interdependent effects of complex building morphology to land surface temperature (LST) variability. The six spatial factors of building density (BD), mean building height (MBH), building height difference (BHD), floor area ratio (FAR), building volume density (BVD) and mean compactness factor (MCF) were calculated at grids of 90, 300, 600 and 900 m. The results showed that BD, MCF and MBH exerted stable and significant impacts on LST with the highest prediction accuracy at 600 m neighborhood scale, and FAR and BVD were the least correlated to LST changes. Meanwhile, the influencing factors presented different correlation patterns with LST. Among them, the increase of BD had a positive linear effect on LST. MCF and MBH were nonlinearly correlated with the LST variation, and their threshold values of cooling effect were also identified. In addition to controlling BD, it also suggested that comprehensively arranging more small-volume buildings as well as increasing building height to enlarge shadow coverage were more conducive to ground heat mitigation.
Neutrophil to lymphocyte ratio (NTLR) predicts local control and overall survival after stereotactic body radiotherapy (SBRT) in metastatic sarcoma
Authors: Somasundaram Eashwar , Anderson Peter M. , Smile Timothy D. , Halima Ahmed , Broughman James B. , Reddy Chandana A. , Parsai Shireen , Scott Jacob G. , Chan Timothy , Campbell Shauna , Angelov Lilyana , Zahler Stacey , Trucco Matteo , Thomas Stefanie M. , Johnson Shavaughn , Qi Peng , Magnelli Anthony , Murphy Erin S. 
Published: November 2023

AbstractThe neutrophil to lymphocyte ratio (NTLR) and absolute lymphocyte count (ALC) recovery are prognostic across many cancers. We investigated whether NLTR predicts SBRT success or survival in a metastatic sarcoma cohort treated with SBRT from 2014 and 2020 (N = 42). Wilcox Signed Rank Test and Friedman Test compare NTLR changes with local failure vs. local control (N = 138 lesions). Cox analyses identified factors associated with overall survival. If local control was successful, NLTR change was not significant (p = 0.30). However, NLTR significantly changed in patients with local failure (p = 0.027). The multivariable Cox model demonstrated higher NLTR before SBRT was associated with worse overall survival (p = 0.002). The optimal NTLR cut point was 5 (Youden index: 0.418). One-year overall survival in SBRT metastatic sarcoma cohort was 47.6% (CI 34.3%–66.1%). Patients with an NTLR above 5 had a one-year overall survival of 37.7% (21.4%–66.3%); patients with an NTLR below 5 had a significantly improved overall survival of 63% (43.3%–91.6%, p = 0.014). Since NTLR at the time of SBRT was significantly associated with local control success and overall survival in metastatic sarcoma treated with SBRT, future efforts to reduce tumor inhibitory microenvironment factors and improve lymphocyte recovery should be investigated.
Social virtual reality helps to reduce feelings of loneliness and social anxiety during the Covid-19 pandemic
Authors: Kenyon Keith , Kinakh Vitalia , Harrison Jacqui 
Published: November 2023

AbstractEvidence shows that the Covid-19 pandemic caused increased loneliness, anxiety and greater social isolation due to social distancing policies. Virtual reality (VR) provides users with an easy way to become engaged in social activities without leaving the house. This study focused on adults, who were socialising in Altspace VR, a social VR platform, during the Covid-19 pandemic and it explored whether social VR could alleviate feelings of loneliness and social anxiety. A mixed-methods research design was applied. Participants (n = 74), aged 18–75, completed a questionnaire inside the social VR platform to measure levels of loneliness (UCLA 20-item scale) and social anxiety (17-item SPIN scale) in the social VR platform (online condition) and real world (offline condition). Subsequently, a focus group (n = 9) was conducted to gather insights into how and why participants were using the social VR platform. Findings from the questionnaire revealed significantly lower levels of loneliness and social anxiety when in the social VR platform. Lower levels of loneliness and social anxiety were also associated with participants who socialised with a regular group of friends. In addition, findings from the focus group suggested that being part of an online group facilitates stronger feelings of belonging. Social VR can be used as a valuable intervention to reduce feelings of loneliness and social anxiety. Future studies should continue to establish whether social VR can help to encourage group formation and provide people with enhanced social opportunities beyond the COVID-19 pandemic.
Ptychographic lens-less birefringence microscopy using a mask-modulated polarization image sensor
Authors: Kim Jeongsoo , Song Seungri , Kim Hongseong , Kim Bora , Park Mirae , Oh Seung Jae , Kim Daesuk , Cense Barry , Huh Yong-min , Lee Joo Yong , Joo Chulmin 
Published: November 2023

AbstractBirefringence, an inherent characteristic of optically anisotropic materials, is widely utilized in various imaging applications ranging from material characterizations to clinical diagnosis. Polarized light microscopy enables high-resolution, high-contrast imaging of optically anisotropic specimens, but it is associated with mechanical rotations of polarizer/analyzer and relatively complex optical designs. Here, we present a form of lens-less polarization-sensitive microscopy capable of complex and birefringence imaging of transparent objects without an optical lens and any moving parts. Our method exploits an optical mask-modulated polarization image sensor and single-input-state LED illumination design to obtain complex and birefringence images of the object via ptychographic phase retrieval. Using a camera with a pixel size of 3.45 μm, the method achieves birefringence imaging with a half-pitch resolution of 2.46 μm over a 59.74 mm2 field-of-view, which corresponds to a space-bandwidth product of 9.9 megapixels. We demonstrate the high-resolution, large-area, phase and birefringence imaging capability of our method by presenting the phase and birefringence images of various anisotropic objects, including a monosodium urate crystal, and excised mouse eye and heart tissues.
Multichannel resonant acoustic rheometry system for quantification of coagulation of multiple human plasma samples
Authors: Hendren Christina , Li Weiping , Stegemann Jan P. , Hall Timothy L. , Deng Cheri X. 
Published: November 2023

AbstractResonant Acoustic Rheometry (RAR), a newly developed ultrasound-based technique for non-contact characterization of soft viscoelastic materials, has shown promise for quantitative viscoelastic assessment of temporally changing soft biomaterials in real time, and may be used to monitor blood coagulation process. Here, we report the development of a novel, multichannel RAR (mRAR) system for simultaneous measurements of multiple temporally evolving samples and demonstration of its use for monitoring the coagulation of multiple small-volume plasma samples. The mRAR system was constructed using an array of 4 custom-designed ultrasound transducers at 5.0 MHz and a novel electronic driving system that controlled the generation of synchronized ultrasound pulses for real time assessment of multiple samples simultaneously. As a proof-of-concept of the operation of the mRAR system, we performed tests using pooled normal human plasma samples and anti-coagulated plasma samples from patients treated with warfarin with a range of International Normalized Ratio (INR) values as well-characterized samples with different coagulation kinetics. Our results show that simultaneous tracking of dynamic changes in 4 plasma samples triggered by either kaolin or tissue factor was achieved for the entire duration of coagulation. The mRAR system captured distinct changes in the samples and identified parameters including the clotting start time and parameters associated with the stiffness of the final clots that were consistent with INR levels. Data from this study demonstrate the feasibility of the mRAR system for efficient characterization of the kinetic coagulation processes of multiple plasma samples.
Simulation of bi-directional pedestrian flow in corridor based on direction fuzzy visual field
Authors: Li Shiwei , Li Qianqian , Zhong Ganglong , Zhang Yuzhao 
Published: November 2023

AbstractBi-directional pedestrian flow in corridors is a complex dynamic system due to the diversity in pedestrian psychological characteristics. Incorporating individual differences of pedestrians is vital for improving pedestrian flow models. However, due to the inherent complexity and variability of pedestrian movement, model parameter calibration remains challenging. Controlled experiments are needed to collect empirical pedestrian movement data under different environments. This enriches the database on pedestrian movement patterns and provides necessary support for improving pedestrian flow models. To address this issue, we conducted controlled experiments to quantify pedestrian heterogeneity by defining the direction of fuzzy visual field (DFVF). The DFVF incorporates various static and dynamic pedestrian factors. We used it to modify the traditional cellular automata model. This improved model simulates bi-directional pedestrian movements in the corridors, reproduces density-speed and density-volume relationships, and reveals self-organization phenomena. Furthermore, an analysis was conducted to examine the impacts of pedestrian density and facility spatial layout on evacuation time. Pedestrian interactions were also studied to uncover fundamental bi-directional flow properties. As pedestrian density increased, the evacuation time showed an exponential upward trend. Corridor length significantly impacts evacuation time, while increasing corridor width helps control it. As crowd density increases, pedestrian flows exhibit three distinct steady states: the strolling flow at low densities, directional separated flows at medium densities, and dynamic multi-lane flows at high densities. In summary, the modified cellular automata model successfully incorporates pedestrian heterogeneity and reveals intrinsic bi-directional pedestrian flow patterns. This study provides valuable insights for pedestrian facility design and optimizing pedestrian flow organization.
Ag-CuO/epoxy hybrid nanocomposites as anti-corrosive coating and self-cleaning on copper substrate
Authors: Abdel-karim Amal M. , Ahmed Yousra M. , El-Masry Mai M. 
Published: November 2023

AbstractThis study aims to prepare Ag-CuO nanoparticles and assess their efficiency in protecting the copper substrate. The prepared Ag-CuO nanoparticle was characterized using, Fourier-transform infrared spectroscopy (FTIR), X-ray diffraction (XRD), scanning electron microscope/energy-dispersive X-ray (SEM/EDX), and transmission electron microscope (TEM). The anticorrosion performance of the epoxy coatings containing various weight percentages of Ag-CuO nanoparticles was evaluated in 3.5 wt% NaCl solution using potentiodynamic polarization (PDP), and electrochemical impedance spectroscopy (EIS) techniques. The results showed that corrosion potential shifted from − 0.211 V for uncoated copper to − 0.120 V for 5.0 wt% Ag-CuO/epoxy hybrid nanocomposite. Electrochemical measurements indicated that the coating 5.0 wt% coating exhibited excellent inhibiting properties with an efficiency of 99.9%. Wettability and mechanical properties were measured for both uncoated and coated copper substrates. The contact angle for 5.0 wt% coating is equal to 104° enhancing the hydrophobic character of the surface. The study clearly establishes that the hybrid composite has a significant potential for protecting the copper substrate.
Fabrication of environmentally safe antifouling coatings using nano-MnO2/cellulose nanofiber composite with BED/GMA irradiated by electron beam
Authors: Moawad Madelyn N. , El-Damhogy Khaled A. , Ghobashy Mohamed Mohamady , Radwan Islam M. , Alabssawy Ahmed Nasr 
Published: November 2023

AbstractMarine biofouling, undesirable growth of organisms on submerged surfaces, poses significant challenges in various industries and marine applications. The development of environmentally safe antifouling coatings employing nano-MnO2/cellulose nanofiber (CNF) composite with bisphenol A epoxy diacrylate/glycidyl methacrylate (BED/GMA) irradiated by electron beam (T1) has been achieved in the current work. The physico-chemical characteristics of the fabricated coatings have been studied using Fourier transforms infrared spectroscopy, scanning electron microscope, water contact angle, and X-ray diffraction. The efficacy of T1 formulation and pure BED/GMA polymer (T2) in inhibiting biofouling formation was investigated in seawater of Alexandria Eastern Harbour by examining biofilm development morphologically and biochemically. In addition, regular analyses of seawater physicochemical parameters were conducted monthly throughout study. Results provide valuable information on coating performance as well as the complex interactions between coatings, biofilms, and environmental factors. The T1 formulation exhibited strong anti-fouling and anticorrosion properties over 2 months. However, after four months of immersion, all coated steel surfaces, including T1, T2, and T0, were heavily covered with macro-fouling, including tubeworms, barnacles, and algae. Biochemical analysis of extracellular polymeric substances (EPS) showed statistically significant variations in carbohydrates content between the coated surfaces. The T1 formulation showed decreased protein and carbohydrate content in EPS fractions after 14 days of immersion indicating less biofouling. Moreover, elemental analysis showed that carbon, oxygen, and iron were the predominant elements in the biofilm. Other elements such as sodium, silicon, chloride, and calcium were in lower concentrations. T2 and T0 surfaces revealed higher calcium levels and the appearance of sulphur peaks if compared with T1 surface. Diatoms and bacteria were detected on T1, T2, and T0 surfaces. The observed warming of seawater and nutrient-rich conditions were found to promote the growth of fouling organisms, emphasizing the importance of considering environmental factors in biofouling management strategies.
Influence of limb dominance on body and jump asymmetries in elite female handball
Authors: Carrasco-Fernández Laura , García-Sillero Manuel , Jurado-Castro Jose Manuel , Borroto-Escuela Dasiel Oscar , García-Romero Jerónimo , Benítez-Porres Javier 
Published: November 2023

AbstractHandball is a team sport subjected to asymmetric actions that require high physical capacity demands on players. The development of large asymmetries could negatively affect sports performance. However, few studies have analyzed body composition and the force asymmetries in elite female handball players. The aim of this study was to analyze the presence of asymmetries based on limb dominance in body composition parameters and lower limb power in jumping performances in an elite women’s handball team. An entire elite women’s handball team, comprised by of 14 players, was analyzed. Dual X-ray Absorptiometry (DXA) and bioimpedance were used to analyze body composition. Force plates were used to evaluate jump performance. Results show the presence of differences between all the players in the different parameters of the CMJ jump. In addition, an asymmetry between the power of the dominant and non-dominant lower limb was observed between the players. The results show differences in muscle mass between the upper limbs, but not in the lower limbs in terms of both muscle and fat mass. However, there were no crossed asymmetries or significant differences between members based on dominance. The results suggest that the presence of asymmetries does not have to be one of the main parameters to be taken into account by coaches in elite athletes and to highlight the importance of including specific analyzes of body composition and sports performance in an individualized way.
Management of partial-thickness rotator cuff tears with autologous adipose-derived regenerative cells is safe and more effective than injection of corticosteroid
Authors: Lundeen Mark , Hurd Jason L. , Hayes Matthew , Hayes Meredith , Facile Tiffany R. , Furia John P. , Maffulli Nicola , Alt Christopher , Alt Eckhard U. , Schmitz Christoph , Pearce David A. 
Published: November 2023

AbstractSymptomatic, partial-thickness rotator cuff tears (sPTRCT) are problematic. This study tested the hypothesis that management of sPTRCT with injection of fresh, uncultured, unmodified, autologous, adipose-derived regenerative cells (UA-ADRCs) is safe and more effective than injection of corticosteroid even in the long run. To this end, subjects who had completed a former randomized controlled trial were enrolled in the present study. At baseline these subjects had not responded to physical therapy treatments for at least 6 weeks, and were randomly assigned to receive respectively a single injection of UA-ADRCs (n = 11) or a single injection of methylprednisolone (n = 5). Efficacy was assessed using the ASES Total score, pain visual analogue scale (VAS), RAND Short Form-36 Health Survey and range of motion at 33.2 ± 1.0 (mean ± SD) and 40.6 ± 1.9 months post-treatment. Proton density, fat-saturated, T2-weighted MRI of the index shoulder was performed at both study visits. There were no greater risks connected with injection of UA-ADRCs than those connected with injection of corticosteroid. The subjects in the UA-ADRCs group showed statistically significantly higher mean ASES Total scores than the subjects in the corticosteroid group. The MRI scans at 6 months post-treatment allowed to “watch the UA-ADRCs at work”.
Association between mass media exposure and infant and young child feeding practices in India: a cross-sectional study
Authors: Dhawan Dhriti , Pinnamaneni Ramya , Viswanath K. 
Published: November 2023

AbstractThe first two years of life is a critical window for good nutrition. Promoting infant and young child feeding (IYCF) practices in the first two years can help improve child survival and promote healthy growth and development. Assessment of IYCF practices is important, especially in developing countries like India where optimal IYCF practices can potentially prevent 12% of all deaths under 5 years of age, to promote awareness and intervene appropriately. The objective of our study is to generate evidence for the association between different types of mass media and appropriate IYCF practices in India, including optimal breastfeeding and appropriate complementary feeding practices. A positive association between them can point to intervention at scale. We analyzed data from India’s National Family Health Survey 5 (NFHS-5), 2019–2021. Multivariable logistic regression was used to examine the association of appropriate IYCF practices with mass media exposure. After controlling for demographics and socioeconomic status, the analyses showed that, overall, women who had exposure to television followed by newspaper and movies, had higher odds of adopting the recommended IYCF practices. The results also showed that the association of media exposure varied for different IYCF practices by geography. For instance, in the rural areas, television exposure was positively associated with all the IYCF practices, but in the urban areas, television exposure was positively associated with only early initiation of breastfeeding [OR 1.25; (95% CI 1.1–1.42)]. The study strengthens our understanding that an appropriate selection of mass media channels for intervention programs can promote IYCF practices at scale. Appropriately selecting the type of mass media to create awareness about different IYCF practices, in specific urban–rural settings, could help customize intervention programs to successfully influence IYCF behaviors.
Plasma level of omentin-1, its expression, and its regulation by gonadotropin-releasing hormone and gonadotropins in porcine anterior pituitary cells
Authors: Respekta Natalia , Pich Karolina , Mlyczyńska Ewa , Dobrzyń Kamil , Ramé Christelle , Kamiński Tadeusz , Smolińska Nina , Dupont Joëlle , Rak Agnieszka 
Published: November 2023

AbstractOmentin-1 (OMNT1) is an adipokine involved in the regulation of energy metabolism, insulin sensitivity, and reproduction. The present study was the first to investigate the plasma levels and expression of OMNT1 in the anterior pituitary (AP) gland on days 2–3, 10–12, 14–16, and 17–19 of the estrous cycle of normal-weight Large White (LW) and fat Meishan (MS) pigs. Next, we determined the effect of GnRH, LH, and FSH on the OMNT1 levels in cultured AP cells. The gene and protein expression of OMNT1 in AP fluctuated during the estrous cycle, with a higher expression in MS than in LW (except on days 10–12). However, plasma levels of OMNT1 were higher in LW than in MS. OMNT1 was localized in somatotrophs, lactotrophs, thyrotrophs, and gonadotrophs. In LW pituitary cells, GnRH and gonadotropins stimulated OMNT1 protein expression (except FSH on days 14–16) and had no effect on OMNT1 levels in the culture medium. In MS pituitary cells, we observed that GnRH and LH increased while FSH decreased OMNT1 protein expression. These findings showed OMNT1 expression and regulation in the porcine AP and suggested that OMNT1 could be a new player modifying the pituitary functions.
Longitudinal dynamics of circulating miRNAs in a swine model of familial hypercholesterolemia during early atherosclerosis
Authors: Namous Hadjer , Krueger Christian , Cheng Yanping , Melo Pedro H. C. , Peppas Athanasios , Kaluza Grzegorz L. , Stoffregen William C. , Reed Jess , Khatib Hasan , Granada Juan F. 
Published: November 2023

AbstractAtherosclerosis is a complex progressive disease involving intertwined biological mechanisms. We aimed to identify miRNA expression dynamics at the early stages of atherosclerosis using a large swine model (Wisconsin Miniature Swine, WMS). A total of 18 female pigs; 9 familial hypercholesterolemic (WMS-FH) and 9 normal control swine (WMS-N) were studied. miRNA sequencing was performed on plasma cell-free RNA at 3, 6, and 9 months of age. RT-qPCR validated DE miRNAs in a new cohort of animals (n = 30) with both sexes. Gene ontology and mRNA targets for DE miRNAs were identified. In vivo multimodality imaging and histopathology were performed to document the presence of atherosclerosis at termination. 20, 19, and 9 miRNAs were significantly DE between the groups at months 3, 6, and 9, respectively. Most DE miRNAs and their target genes are involved in human atherosclerosis development. Coronary atherosclerosis was documented in 7/9 WMS-FH pigs. Control animals had no lesions. miR-138, miR-152, miR-190a, and miR-196a showed a significant diagnostic power at month 3, whereas miR-486, miR-126-3p, miR-335, and miR-423-5p were of significant diagnostic power at month 9. In conclusion, specific DE miRNAs with significant discriminatory power may be promising biomarkers for the early detection of coronary atherosclerosis.