bluuebunny/crossref_metadata_2025_split huggingface dataset:
Demand management processes to improve access to cognitive-behavioral therapies for anxiety disorders: a grounded theory study
Authors: Carrier Jean-Daniel , Gallagher Frances , Vanasse Alain , Roberge Pasquale 
Published: January 2024

IntroductionAnxiety disorders are impactful mental health conditions for which evidence-based treatments are available, notably cognitive-behavioral therapies (CBTs). Even when CBTs are available, demand-side factors limit their access, and actors in a position to perform demand management activities lack a framework to identify context-appropriate actions.MethodsWe conducted a constructivist grounded theory study in Quebec, Canada, to model demand management targets to improve access to CBTs for anxiety disorders. We recruited key informants with diverse experiences using purposeful, then theoretical sampling. We analyzed data from 18 semi-directed interviews and 20 documents through an iterative coding process centered around constant comparison.ResultsThe resulting model illustrates how actors can target clinical-administrative processes fulfilling the demand management functions of detection, evaluation, preparation, and referral to help patients progress on the path of access to CBTs.DiscussionModeling clinical-administrative processes is a promising approach to facilitate leveraging the competency of actors involved in demand management at the local level to benefit public mental health.
The effect of heat mitigation strategies on thermoregulation and productivity during simulated occupational work in the heat in physically active young men
Authors: Morrissey-Basler Margaret C. , Brewer Gabrielle J. , Anderson Travis , Adams William M. , Navarro John S. , Marcelino Monique , Martin David G. , Casa Douglas J. 
Published: January 2024

PurposeTo investigate heat stress mitigation strategies on productivity and thermoregulatory responses during simulated occupational work in the heat.MethodsThirteen physically active men (age, 25 ± 4 years; body mass,77.8 ± 14.7 kg; VO2peak, 44.5 ± 9.2 ml·kg−1·min−1) completed five randomized-controlled trials in a hot environment (40°C, 40% relative humidity). Each trial was 4.5 h in duration to simulate an outdoor occupational shift. Thermoregulatory responses (heart rate, HR; rectal temperature, Trec; mean skin temperature, Tsk), perceptual responses (rating of perceived exertion, RPE; thermal sensation; thermal comfort; fatigue) and productivity outcomes (box lifting repetitions, time to exhaustion) were examined in the following heat mitigation strategy interventions: (1) simulated solar radiation with limited fluid intake [SUN]; (2) simulated solar radiation with no fluid restrictions [SUN + H2O]; (3) shade (no simulated solar radiation during trial) with no fluid restrictions [SHADE + H2O]; (4) shade and cooling towels during rest breaks with no fluid restrictions [COOL + H2O]; and (5) shade with cooling towels, cooling vest during activity with no fluid restrictions [COOL + VEST + H2O].Results[COOL + VEST + H2O] had lower Trec compared to [SUN] [p = 0.004, effect size(ES) = 1.48], [SUN + H2O] (p &lt; 0.001, ES = −1.87), and [SHADE + H2O] (p = 0.001, ES = 1.62). Average Tsk was lower during the treadmill and box lifting activities in the [COOL + VEST + H2O] compared to [SUN] (p &lt; 0.001, ES = 7.92), [SUN + H2O] (p &lt; 0.001,7.96), [SHADE + H2O] (p &lt; 0.001), and [COOL + H2O] (p &lt; 0.001, ES = 3.01). There were performance differences during the [COOL + VEST + H2O] (p = 0.033) and [COOL + H2O] (p = 0.023) conditions compared to [SUN] during phases of the experimental trial, however, there were no differences in total box lifting repetitions between trials (p &gt; 0.05).ConclusionOur results suggest that during a simulated occupational shift in a laboratory setting, additional heat mitigation strategies ([COOL + VEST + H2O] and [COOL + H2O]) reduced physiological strain and improved box lifting performance to a greater degree than [SUN]. These differences may have been attributed to a larger core to skin temperature gradient or reduction in fatigue, thermal sensation, and RPE during [COOL + H2O] and [COOL + VEST + H2O]. These data suggest that body cooling, hydration, and “shade” (removal of simulated radiant heat) as heat stress mitigation strategies should be considered as it reduces physiological strain while producing no additional harm.
Surgical management of abdominal wall sheath and rectus abdominis muscle endometriosis: a case report and literature review
Authors: Triantafyllidou Olga , Mili Nikoletta , Kalampokas Theodoros , Vlahos Nikolaos , Kalampokas Emmanouil 
Published: January 2024

IntroductionEndometriosis, defined as the presence of endometrial glands and stroma outside the uterine cavity, mainly affects the pelvic viscera and peritoneum. Endometriosis can also occur at sites of surgical incisions on the abdominal wall, mainly in women with a history of cesarean section (CS). The incidence of abdominal wall endometriosis after CS reaches 1%. Clinical suspicion, along with imaging, plays a crucial role in diagnosis. The preferred treatment involves extensive surgical excision with clear margins, ensuring a definitive diagnosis through histopathology examination.Case presentationThis case report is of a 44-year-old woman with a history of two CS procedures who developed pain and pigmentation at the incisional site one year after the last CS. Thirteen years after the surgical excision of an abdominal wall endometriosis (AWE) mass, followed by hormone therapy, she presented in our hospital with worsening pain for further management. Pelvic MRI findings were consistent with AWE. During surgery, the abdominal wall endometriosis foci were removed, and the defect in the aponeurosis was repaired using a dual-sided mesh in a tension-free procedure.ConclusionAlthough AWE is a rare condition, we foresee an increase in cases because of the ever-increasing CS rates and the important association between AWE and CS. Healthcare practitioners should remain vigilant for this condition in women of reproductive age who exhibit cyclic pain, a palpable mass in the abdomen, and a background of previous uterine surgeries.
Downstaging and laparoscopic hepatectomy plus intraoperative radiofrequency ablation for the treatment of initially unresectable multifocal hepatocellular carcinomas
Authors: Wang Jianjun , Luo Hua , Yi Long , Yang Pei , Zeng Xintao 
Published: January 2024

BackgroundUsing TKIs plus anti-PD-1 antibodies combined with TACE in the treatment of patients with initially unresectable multiple HCCs has a high tumour response rate, and using laparoscopic hepatectomy (LH) combined with intraoperative RFA for radical treatment of multiple HCCs after successful downstaging treatment has not been reported.MethodsConsecutive patients with multiple HCCs (≤4 lesions) who were downstaged with TKIs plus anti-PD-1 antibodies combined with TACE were analysed. Imaging examinations were performed monthly, and RECIST v1.1 criteria were used to evaluate treatment effect and resectability.ResultsForty-five consecutive patients with multiple HCCs who met the inclusion criteria received downstaging treatment with TKIs plus anti-PD-1 antibodies combined with TACE. Nine patients were successfully downstaged and met the R0 resection criteria, and 8 patients underwent surgery. Among the patients, 5 patients had BCLC stage C, and 3 patients had BCLC stage B. There were 2 lesions in 5 patients, 3 lesions in 2 patients, and 4 lesions in 1 patient. The average size of the main HCC was 8.5 cm (range: 5.4–9.1 cm), and the diameter of the remaining HCCs was 1.6 cm (range: 0.8–2.9 cm). The average time from the start of downstaging therapy to surgery was 81 days (range: 60–210 days). All 8 patients underwent LH of the main HCC, and the remaining HCCs were targeted with RFA. The mean operation time was 220 min (range 150–370 min), the average intraoperative blood loss was 260 ml (range 100–750 ml), there was no case conversion to laparotomy, and the average postoperative hospital stay was 9 days (range 7–25 days). The incidence of postoperative complications was 37.5% and there were no deaths. The average follow-up time was 18.2 months (range 6.1–22.4 months), 5 patients survived tumour-free, 2 patients had tumour recurrence, and 1 patient died.ConclusionsAfter successful downstaging of multiple HCCs by treatment with TKIs plus anti-PD-1 antibodies and TACE, LH combined with RFA for radical surgery is safe and feasible, and the treatment effect is satisfactory. It is worthy of clinical reference, and its long-term effects require further research for confirmation.
Maternal exposure to zinc oxide nanoparticles causes cochlear dysfunction in the offspring
Authors: Campagnolo Luisa , Lacconi Valentina , Bernardini Roberta , Viziano Andrea , Pietroiusti Antonio , Ippoliti Lorenzo , Moleti Arturo , Sisto Renata 
Published: January 2024

Introduction: Zinc oxide nanoparticles (ZnO NPs) have been engineered and are largely used in material science and industry. This large and increasing use justifies a careful study about the toxicity of this material for human subjects. The concerns regard also the reproductive toxicity and the fetotoxicity.Materials and methods: The effect of the exposure to ZnO NPs on the cochlear function was studied in a group of pregnant CD1 mice and in their offspring. This study is part of a larger toxicological study about the toxicity of ZnO NPs during pregnancy. Four groups were analyzed and compared, exposed and non-exposed dams and their offspring. The cochlear function was quantitatively assessed by means of Distortion Product Otoacoustic Emissions (DPOAEs).Results and discussion: A large statistically significant difference was found between the non-exposed dams offspring and the exposed dams offspring (p = 1.6 · 10−3), whose DPOAE levels were significantly lower than those of non-exposed dams offspring and comparable to those of the adults. The DPOAE levels of the exposed and non-exposed dams were very low and not significantly different. This occurrence is related to the fact that these mice encounter a rapid aging process.Conclusion: Our findings show that maternal exposure to ZnO NPs does not reflect in overt toxicity on fetal development nor impair offspring birth, however it may damage the nervous tissue of the inner ear in the offspring. Other studies should confirm this result and identify the mechanisms through which ZnO NPs may affect ear development.
No Reason to Use Mesh in Groin Hernia Repair in Adolescents
Authors: Reistrup Hugin , Fonnes Siv , Rosenberg Jacob 
Published: January 2024

Groin hernias are common and hernia repair is one of the most frequent surgical procedures performed worldwide. Despite this, there is no international guideline on the management of groin hernias in adolescents. Mesh reinforcement is used for repair in adults but not in young children. Adolescents, positioned between these age groups, pose unique challenges for surgeons due to their varying growth patterns. Placing a synthetic mesh in growing patients is a concern, particularly in relation to chronic pain. Traditionally, the hernia literature has defined adults as individuals aged 18 years and above. Considering that growth can continue until age 19, this review proposes a revised definition of adolescence for patients with groin hernias encompassing ages 10 to 19. Symptomatic groin hernias in adolescents should be repaired with an open non-mesh technique because of acceptable recurrence rates and the desire to avoid introducing synthetic foreign materials into young patients with ongoing growth potential. Watchful waiting is suggested for asymptomatic groin hernias, postponing repair until the adolescent has become a fully grown adult and symptoms from the hernia develop. Most groin hernias in adolescents are lateral hernias, but before pursuing a watchful waiting strategy in females, an ultrasound or magnetic resonance imaging scan is suggested to rule out the presence of a femoral hernia that may need repair.
Periodontitis as a risk factor for cardiovascular disease development: systematic review
Authors: Zykova A. S. , Opravin A. S. , Soloviev A. G. 
Published: January 2024

Relevance. The high prevalence of inflammatory periodontal diseases (IPD) and periodontitis, in particular, is a relevant issue since the latter progression leads to alveolar bone destruction and loss of periodontal attachment and is considered one of the principal causes of tooth loss in the adult population. The adverse impact of periodontal pathogens doesn't only extend to the oral organs and tissues, but it also affects general health. There is evidence of a possible relationship between IPD and cardiovascular diseases (CVD). Periodontal pathogens are found in the myocardium, pericardial fluid, heart valves and vascular intima.Purpose. The study aimed to systematically review the impact of periodontitis on the risk of cardiovascular disease development.Material and methods. The study systematically reviewed scientific articles and original studies from international and national databases using the PRISMA (The Preferred Reporting Items for Systematic Reviews and Meta-Analyses) checklist for systematic reviews and meta-analyses.Results. The study detected 1857 articles according to the inclusion criteria. After the duplicate removal, the number of articles decreased to 685. Of these, 137 articles were selected for screening, which contained data from randomized controlled clinical trials, longitudinal studies, cohort studies and case-control studies. Ninety-eight articles were excluded for the lack of clinical diagnoses or clear diagnostic criteria for the studies and the lack of sample representativeness. The experts assessed 39 articles, of which seven were removed due to a high risk of bias. Finally, 32 studies were included in the systematic review.Conclusion. Thus, the review confirms the hypothesis that there is a relationship between IPD and CVD, such as ACVD, myocardial infarction, peripheral vascular disease, and hypertension. The theory of the pathogenic influence of systemic inflammation caused by the spread of periodontal pathogens in the bloodstream is the key option for grounding this relationship.
Influence of Talent Management and Core Values on Employee Performance in State-Owned Enterprises in Bandung
Authors: Putri Shabrina Nabilah , Sary Fetty Poerwita 
Published: January 2024

Objective: The objective of this study was to examine the impact of talent management and company core values on employee work performance. Finding the relationship between all crucial components, this research is vital for the development of science, particularly in the domain of human capital and talent development. Research Design & Methods: Using a quantitative research method, the study collected data from a minimum sample of 100 employees of State-Owned Enterprises in Bandung. PLS-SEM analysis was conducted using SmartPLS 3.2.9 software to test the research hypotheses. Findings: The results revealed that talent management had no significant effect on employee work performance, while company core values had a positive and significant impact on this variable. It was also found that both talent management and company core values demonstrated simultaneous influences on employee work performance. Implications & Recommendations: This study has important implications for companies seeking to enhance the work performance of their employees. Specifically, the findings suggest that strengthening both company management talent and core values may be necessary to achieve this goal. Contribution & Value Added: In terms of contribution and value added, this research offers an overview of the challenges associated with poor talent management and company core values, and their potential impact on job performance. By providing insight into these issues, the study offers valuable guidance to organizations seeking to improve the performance of their employees.
Isolamento, identificação e potencial biotecnológico de fungos endofíticos associados à planta Jambú (Acmella ciliata)
Authors: Nogueira Vittoria Horner , Aguiar Aline Aires , Otaviano Divino José , Gellen Luís Fernando Albarello , Sesti Luís Fernando Castagnino , Santos Mateus Silva , Bastos Ernane Gerre Pereira 
Published: January 2024

Este estudo visa identificar fungos endofíticos associados à planta Jambú (Acmella ciliata) em busca de microrganismos que produzem bioativos como: peptídeos, esteróides, fenóis, quinonas e flavonóides. As amostras foram coletadas e isoladas de10 fungos, preservados e os extratos fúngicos foram obtidos. O DNA fúngico foi extraído e amplificado através da PCR 6 amostras com os oligonucleotídeos ITS1 e ITS4 para identificação genética dos fungos e está sendo realizado o sequenciamento genético que irá ser depositado e comparado no banco de dados NCBI (National Center for Biotechnology ).O extrato fúngico foi submetido ao teste de Determinação da Concentração Inibitória Mínima (CIM) obteve resultados promissores com 100% dos extratos com inibição do crescimento bacteriano da E.coli com valor mínimo de 125 μg/mL, já os realizados com S. aureus as amostras, A1F2; A1F3; A1F5; A2F5, nos extratos alcoólico e no hexano obteve um valor mínimo de 500 μg/mL. A amostra A1F1 em extrato alcoólico teve um valor mínimo de 250 μg/mL, em hexano em 500 μg/mL. Concluímos que por meio desses estudos prévios a sim uma rica biodiversidade de fungos endofíticos no Jambú com potencial antibacteriano como demonstrado nos testes de CIM com resultados satisfatórios na inibição bacteriana, a amplificação do DNA fúngico permitirá saber as linhagens possuem essa capacidade microbicida e tem grande importância para estudos futuros.
Analisis Potensi Kecelakaan dan Penyakit Akibat Kerja pada Bagian Mesin Molding dengan Metode Hazard and Probability Study (HAZOP) di PT. XYZ
Authors: Pasaribu Tigor Gabriel , Sari Rianita Puspa 
Published: January 2024

PT. XYZ is a company engaged in manufacturing elastomer switches with a molding machine as one of the machines in the production process at the company. Based on field observations, many workers are not prioritizing work safety by disobeying work procedures in the molding machine section, in which there are work activities that have the potential to cause work accidents, including operating molding machines, dry ice molding machines, moving molds, washing chemicals molds and repairing molds. Data analysis was carried out using descriptive data analysis techniques using the Hazard and Operabilty (HAZOP) method. Based on the results of observations and interviews with employees including operators, operator leaders and the Committee for Occupational Safety and Health, that there are a total of 44 potential or occupational hazard risks and are related to every job in the molding machine section, with a description of the high risk of 41% or 18 risk, moderate risk of 52% or 23 risk, and low risk of 7% or 3 risk. From the results of the identification of the risk assessment, it shows that there are still dangerous risks for workers with a high level of 41%, which means that control and corrective actions must be taken so that the work risk will not become a work accident in every activity or work on the molding machine.Â Â PT. XYZ merupakan perusahaan yang bergerak di bidang manufacturing elastomer switch dengan mesin molding sebagai salah satu mesin dalam proses produksi di perusahaan tersebut. Berdasarkan pengamatan di lapangan, banyak para pekerja yang kurang dalam mengutamakan keselamatan kerja dengan tidak menaati prosedur kerja di bagian mesin molding yang di dalamnya terdapat aktivitas kerja yang berpotensi menyebabkan kecelakaan kerja meliputi kegiatan pengoperasian mesin molding, dry ice mesin molding, pemindahan mold, washing chemical mold dan repairing mold. Analisa data dilakukan dengan teknik analisa data secara deskriptif dengan metode Hazard and Operabilty (HAZOP). Berdasarkan hasil observasi dan wawancara terhadap karyawan yang meliputi operator, leader operator dan Panitia Pembina Keselamatan dan Kesehatan Kerja, bahwa terdapat jumlah potensi atau risiko bahaya kerja terdapat 44 risiko dan berkaitan pada setiap pekerjaan di bagian mesin molding, dengan uraian yaitu, risiko tinggi sebesar 41% atau 18 risiko, risiko sedang sebesar 52% atau 23 risiko, dan risiko rendah sebesar 7% atau 3 risiko. Dari hasil identifikasi penilaian risiko tersebut menunjukkan bahwa masih terdapat risiko-risiko membahayakan bagi para pekerja dengan level yang tinggi sebesar 41% yang berarti harus dilakukan tindakan pengendalian dan perbaikan agar risiko kerja tersebut tidak akan menjadi kecelakaan kerja di setiap kegiatan atau pekerjaan pada bagian mesin molding.
Analisis Risiko Postur Kerja dengan Metode Nordic Body Map, RULA dan REBA pada Proses Manual Material Handling Pabrik Kecap
Authors: Rezki Annisa Sabarina , Maksum Apid Hapid , Herwanto Dene , Rahmat Muhamad Taufiq 
Published: January 2024

Repetitive manual material handling and incorrect movements can result injury to workers. At the Kecap Segi Tiga Majalengka Company, several workers had complaints of low back pain, shoulder pain, leg pain, and others after work. This study focused on analyzing the work posture risks of two workers in the washing and labeling bottles section. The used method was the NBM questionnaire after work and observation. The data that has been collected then processed using the Nordic Body Map (NBM), RULA, and REBA methods. The three methods produce a score that indicating the high risk of injury of work posture. NBM method showed result that bottle-washing workers felt more pain with a value of 52 compared with labeling workers who have a value of 49. The RULA method produces a score of 7 for both jobs which means the way it included the process works in risky activities and needs work repair right now. While the REBA method found that the bottle washing process resulted in a total score of 11 (Very High), Action Level 4, and required immediate repairs and the installation of soy sauce bottle labels it resulted in a total value of 9 (High), Action Level 3, and needed immediate corrective action.Â Konsep Manual Material Handling yang ada di dalam suatu kegiatan usaha berpotensi menimbulkan cedera pada tubuh pekerja jika dilakukan secara repetitif dengan waktu lama. Pada Perusahaan Kecap Segi Tiga Majalengka, didapati beberapa pekerja memiliki keluhan seperti nyeri pinggang, nyeri pundak, sakit kaki, dan lain-lain setelah bekerja. Penelitian ini bertujuan untuk menganalisis besar risiko yang dihasilkan dari postur kerja kedua pekerja yang berada di bagian pencucian dan pemasangan label botol Perusahaan Kecap Segi Tiga Majalengka. Metode yang digunakan adalah dengan pengisian kuesioner Nordic Body Map ditambah metode observasi. Data yang telah dikumpulkan kemudian diolah dengan metode Nordic Body Map (NBM), RULA, dan REBA. Ketiga metode tersebut menghasilkan nilai yang mengindikasikan bahwa postur kerja yang dimiliki berisiko tinggi menimbulkan cedera. Metode NBM menunjukkan bahwa pekerja pencucian botol cenderung lebih merasa sakit dengan nilai 52 dibandingkan dengan pekerja pemasangan label yang bernilai 49. Untuk metode RULA didapati bahwa kedua pekerjaan tersebut menghasilkan nilai yang sama yaitu 7 yang berarti cara kerja proses tersebut termasuk pada kegiatan yang berisiko dan memerlukan perbaikan kerja sekarang juga. Sedangkan metode REBA mendapati bahwa proses pencucian botol menghasilkan nilai total 11 (Sangat Tinggi), Action Level 4, dan memerlukan perbaikan saat itu juga dan untuk pemasangan label botol kecap menghasilkan nilai total 9 (Tinggi), Action Level 3, dan perlu tindakan perbaikan segera.