bluuebunny/crossref_metadata_2025_split huggingface dataset:
Longitudinal study of peer victimization, social support, and mental health during early adolescence
Authors: Martínez Matías , Damme Katherine S. , Vargas Teresa , Yang Beiming , Rompilla D. J. , Stephens Jacquelyn , Qu Yang , Mittal Vijay A. , Haase Claudia M. 
Published: February 2024

AbstractBackgroundPeer victimization predicts the development of mental health symptoms in the transition to adolescence, but it is unclear whether and how parents and school environments can buffer this link.MethodsWe analyzed two-year longitudinal data from the Adolescent Brain Cognitive Development (ABCD) study, involving a diverse sample of 11 844 children across the United States (average at baseline = 9.91 years; standard deviation = 0.63; range = 8.92–11.08; complete case sample = 8385). Longitudinal associations between peer victimization and two-year changes in mental health symptoms of major depression disorder (MDD), separation anxiety (SA), prodromal psychosis (PP), and attention-deficit/hyperactivity disorder (ADHD) were examined including a wide range of covariates. Mixed linear models were used to test for the moderating effects of parental warmth and prosocial school environment.Results20% of children experienced peer victimization. Higher exposure to peer victimization was associated with increases in MDD, SA, and ADHD symptoms. Parental warmth was associated with decreases in MDD symptoms but did not robustly buffer the link between peer victimization and mental health symptoms. Prosocial school environment predicted decreases in PP symptoms and buffered the link between peer victimization and MDD symptoms but amplified the link between peer victimization and SA and ADHD symptoms.ConclusionsPeer victimization is associated with increases in mental health symptoms during the transition to adolescence. Parental warmth and prosocial school environments might not be enough to counter the negative consequences of peer victimization on all mental health outcomes.
The elephant's other legs: What some sciences actually do
Authors: Baron Jonathan 
Published: February 2024

Abstract
Integrative experiments, as described, seem blindly empirical, as if the question of generality of effects could not be understood through controlled one-at-a-time experiments. But current research using such experiments, especially applied research, can resolve issues and make progress through understanding of cause–effect pathways, leaving to engineers the task of translating this understanding into practice.
Eliminativist induction cannot be a solution to psychology's crisis
Authors: Tunç Mehmet Necip , Uygun Tunç Duygu 
Published: February 2024

Abstract
Integrative experiment design assumes that we can effectively design a space of factors that cause contextual variation. However, this is impossible to do so in a sufficiently objective way, resulting inevitably in observations laden with surrogate models. Consequently, integrative experiment design may even deepen the problem of incommensurability. In comparison, one-at-a-time approaches make much more tentative assumptions about the factors excluded from experiment design, hence still seem better suited to deal with incommensurability.
The future of experimental design: Integrative, but is the sample diverse enough?
Authors: Ghai Sakshi , Banerjee Sanchayan 
Published: February 2024

Abstract
Almaatouq et al. propose an “integrative approach” to increase the generalisability and commensurability of experiments. Yet their metascientific approach has one glaring omission (and misinterpretation of) – the role of sample diversity in generalisability. In this commentary, we challenge false notions of subsumed duality between contexts, population, and diversity, and propose modifications to their design space to accommodate sample diversity.
Design and control of a compliant robotic actuator with parallel spring-damping transmission
Authors: Yuan Peikang , Liu Jianbin , Branson David T. , Song Zhibin , Wu Shuai , Dai Jian S. , Kang Rongjie 
Published: February 2024

AbstractPhysically compliant actuator brings significant benefits to robots in terms of environmental adaptability, human–robot interaction, and energy efficiency as the introduction of the inherent compliance. However, this inherent compliance also limits the force and position control performance of the actuator system due to the induced oscillations and decreased mechanical bandwidth. To solve this problem, we first investigate the dynamic effects of implementing variable physical damping into a compliant actuator. Following this, we propose a structural scheme that integrates a variable damping element in parallel to a conventional series elastic actuator. A damping regulation algorithm is then developed for the parallel spring-damping actuator (PSDA) to tune the dynamic performance of the system while remaining sufficient compliance. Experimental results show that the PSDA offers better stability and dynamic capability in the force and position control by generating appropriate damping levels.
TIME POVERTY: CONCEPTUALIZATION, GENDER DIFFERENCES, AND POLICY SOLUTIONS
Authors: Rodgers Yana Van Der Meulen 
Published: February 2024

AbstractIndividuals with heavy paid and unpaid work burdens may experience time deprivations that restrict their well-being and put them at risk of becoming or remaining income poor. Because unpaid work outside of the market is not captured in most large survey-based datasets, time poverty is rarely recognized in policy and practice. Yet income poverty and time poverty are mutually reinforcing; they can sap energy and impede effective decision-making, thus perpetuating the state of poverty. This essay offers a five-step approach to conceptualizing and measuring time poverty and it compares time poverty rates by gender across a range of developing countries. Results show that women have higher time poverty rates than men in most cases, with the main exception being countries with low rates of female labor force participation. Policies that strengthen physical and social infrastructure, thereby decreasing the time needed for unpaid household work, have demonstrable effects on reducing time poverty.
THE PSYCHOLOGY OF POVERTY: WHERE DO WE STAND?
Authors: Haushofer Johannes , Salicath Daniel 
Published: February 2024

AbstractIn recent years, the psychological causes and consequences of poverty have received renewed attention from scientists and policymakers. In this essay, we summarize new developments in this literature. First, we discuss advances in our understanding of the relationship between income and psychological well-being. There is a robust positive relationship between the two, both within and across countries, and in correlational and causal analyses. Second, we summarize recent work on the impact of “scarcity” and stress on economic preferences and decision-making. Our view of this literature is that the evidence is relatively weak. Third, we summarize evidence on the impact of psychological interventions on economic outcomes. Light-touch psychological interventions, such as videos that aim to raise aspirations, have shown some promise in encouraging investment and improving economic well-being. Similarly, psychotherapy and pharmacological mental health treatments have positive effects on economic outcomes. Relative to the effects of cash transfers, these impacts are small in absolute terms and large in per-dollar terms. We conclude by discussing whether a psychological poverty trap is plausible.
Hemichorea–hemiballismus associated with a case of cerebral toxoplasmosis in a hematopoietic stem cell transplant recipient
Authors: Rocha-Cadman Xiomara , Revilla Amanda R. , Cadman Karla , Root James C. 
Published: February 2024

AbstractDue to their immunocompromised state, recipients of hematopoietic stem cell transplants (HSCTs) are at a higher risk of opportunistic infections, such as that of toxoplasmosis. Toxoplasmosis is a rare but mortal infection that can cause severe neurological symptoms, including confusion. In immunosuppressed individuals, such as those with acquired immunodeficiency syndrome (AIDS), toxoplasmosis can cause movement disorders, including hemichorea–hemiballismus. We present the case of a 54-year-old Caucasian male with a history of hypertension and JAK-2-negative primary myelofibrosis who underwent an allogeneic peripheral blood stem cell transplant from a related donor. After the development of acute changes in mental status, left-sided weakness, and left-sided hemichorea–hemiballismus post-transplant, the patient was readmitted to the hospital. Subsequent testing included an magnetic resonance imaging (MRI) of the brain, which revealed multiple ring-enhancing lesions around the thalami and basal ganglia, as well as a cerebrospinal fluid tap that tested positive for toxoplasmosis. The patient was initially treated with intravenous clindamycin and oral pyrimethamine with leucovorin. The completion of treatment improved the patient’s mental status but did not improve his hemichorea–hemiballismus. This case illustrates an uncommon complication associated with central nervous system (CNS) toxoplasmosis in stem cell transplant recipients. Due to its rarity, cerebral toxoplasmosis in immunocompromised patients often remains undetected, particularly in HSCT patients who are immunosuppressed to improve engraftment. Neurological and neuropsychiatric symptoms due to toxoplasmosis may be misidentified as psychiatric morbidities, delaying appropriate treatment. Polymerase chain reaction (PCR) assays offer methods that are sensitive and specific to detecting toxoplasmosis and provide opportunities for early intervention.
Looking at the other side: working conditions in Portuguese courts
Authors: Dias João Paulo , Casaleiro Paula , Gomes Conceição , Jesus Fernanda , Lima Teresa Maneca , Queirós Filipa , Relvas Ana Paula , Sotero Luciana , Henriques Marina , Verzelloni Luca 
Published: February 2024

AbstractQUALIS is a research project that studies ‘the other side of courts’ by looking at the working conditions of judicial professions in Portugal and their impacts on the profession, health, family and personal life. The objective of this article is to provide an overview of the results obtained, based mainly on the interviews and the online questionnaire administered to the Portuguese judicial professions (judges, public prosecutors and court clerks). The questionnaire was sent to all professionals (more than 10,000) working in the courts and had a good response rate; the interviews were conducted among the three judicial professions. The article focuses on three main dimensions of working conditions, namely physical environment, working time and work intensity, and work/social environment of professionals working at first instance courts. It will make then a further analysis of their impacts in the health and well-being and in the work-family conflict of the judicial professionals.
Church and state in contemporary China: securing Christianity
Authors: Jing Peitong , Koesel Karrie J. 
Published: February 2024

Abstract
What is the nature of church–state relations in countries where politics is restrictive, religious autonomy is limited, and Christians tend to be viewed as existential threats by those in power? This article examines the highly securitized environment for Catholics and Protestants in China and the evolving government strategies used to regulate religious life. We argue that these efforts—ranging from channeling Christians into state-sponsored institutions, promoting patriotism in seminaries, and compelling churches to Sinicize—not only extends the reach of the party-state into Christian communities, but also puts the Party at the center of religious life. There are several implications from this analysis. One is that it documents how authoritarian regimes attempt to “domesticate” religion using multi-dimensional and long-term strategies of control. A second demonstrates how strong states, like China, seek to cultivate patriotic clergy and orient them favorably toward the regime. A third shows how Christians navigate restrictive environments.
Psychometric Properties of the Connor-Davidson Resilience Scale (CD-RISC) in Spanish Adolescents
Authors: López-Fernández Francisco Javier , Morales-Hidalgo Paula , Canals Josefa , Marzo Juan Carlos , García-López Luis Joaquín , Piqueras José Antonio 
Published: February 2024

Abstract
Few studies have examined the psychometric properties of the Connor-Davidson Resilience Scale (CD-RISC) in a large adolescent community sample, finding a significant disparity. This study explores the psychometric properties of the CD-RISC among Spanish adolescents by means of exploratory factor analysis (EFA), Rasch analysis, and measurement invariance (MI) across sex, as well as internal consistency and criterion validity. The sample was comprised of 463 adolescents (231 girls), aged 12 to 18 years, who completed the CD-RISC and other measures on emotional status and quality of life. The EFA suggested that the CD-RISC structure presented a unidimensional model. Consequently, shorter unidimensional CD-RISC models observed in the literature were explored. Thus, the Campbell-Sills and Stein CD–RISC–10 showed the soundest psychometric properties, providing an adequate item fit and supporting MI and non-differential item functioning across sex. Item difficulty levels were biased toward low levels of resilience. Some items showed malfunctioning in lower response categories. With regard to reliability, categorical omega was. 82. Strong associations with health-related quality of life, major depressive disorder symptoms, and emotional symptoms were observed. A weak association was found between resilience and the male sex. Campbell-Sills and Stein’s CD–RISC–10 model emerges as the best to assess resilience among Spanish adolescents, as already reported in adults. Thus, independently of the developmental stage, the core of resilience may reside in the aspects of hardiness and persistence.
Early Diagenetic Controls on Sedimentary Iodine Release and Iodine‐To‐Organic Carbon Ratios in the Paleo‐Record
Authors: Scholz Florian , Hardisty Dalton S. , Dale Andrew W. 
Published: February 2024

AbstractIodine cycling in the ocean is closely linked to productivity, organic carbon export, and oxygenation. However, iodine sources and sinks at the seafloor are poorly constrained, which limits the applicability of iodine as a biogeochemical tracer. We present pore water and solid phase iodine data for sediment cores from the Peruvian continental margin, which cover a range of bottom water oxygen concentrations, organic carbon rain rates and sedimentation rates. By applying a numerical reaction‐transport model, we evaluate how these parameters determine benthic iodine fluxes and sedimentary iodine‐to‐organic carbon ratios (I:Corg) in the paleo‐record. Iodine is delivered to the sediment with organic material and released into the pore water as iodide (I−) during early diagenesis. Under anoxic conditions in the bottom water, most of the iodine delivered is recycled, which can explain the presence of excess dissolved iodine in near‐shore anoxic seawater. According to our model, the benthic I− efflux in anoxic areas is mainly determined by the organic carbon rain rate. Under oxic conditions, pore water dissolved I− is oxidized and precipitated at the sediment surface. Much of the precipitated iodine re‐dissolves during early diagenesis and only a fraction is buried. Particulate iodine burial efficiency and I:Corg burial ratios do increase with bottom water oxygen. However, multiple combinations of bottom water oxygen, organic carbon rain rate and sedimentation rate can lead to identical I:Corg, which limits the utility of I:Corg as a quantitative oxygenation proxy. Our findings may help to better constrain the ocean's iodine mass balance, both today and in the geological past.
Upscaling Soil Organic Carbon Measurements at the Continental Scale Using Multivariate Clustering Analysis and Machine Learning
Authors: Wang Zhuonan , Kumar Jitendra , Weintraub‐Leff Samantha R. , Todd‐Brown Katherine , Mishra Umakant , Sihi Debjani 
Published: February 2024

AbstractEstimates of soil organic carbon (SOC) stocks are essential for many environmental applications. However, significant inconsistencies exist in SOC stock estimates for the U.S. across current SOC maps. We propose a framework that combines unsupervised multivariate geographic clustering (MGC) and supervised Random Forests regression, improving SOC maps by capturing heterogeneous relationships with SOC drivers. We first used MGC to divide the U.S. into 20 SOC regions based on the similarity of covariates (soil biogeochemical, bioclimatic, biological, and physiographic variables). Subsequently, separate Random Forests models were trained for each SOC region, utilizing environmental covariates and SOC observations. Our estimated SOC stocks for the U.S. (52.6 ± 3.2 Pg for 0–30 cm and 108.3 ± 8.2 Pg for 0–100 cm depth) were within the range estimated by existing products like Harmonized World Soil Database, HWSD (46.7 Pg for 0–30 cm and 90.7 Pg for 0–100 cm depth) and SoilGrids 2.0 (45.7 Pg for 0–30 cm and 133.0 Pg for 0–100 cm depth). However, independent validation with soil profile data from the National Ecological Observatory Network showed that our approach (R2 = 0.51) outperformed the estimates obtained from Harmonized World Soil Database (R2 = 0.23) and SoilGrids 2.0 (R2 = 0.39) for the topsoil (0–30 cm). Uncertainty analysis (e.g., low representativeness and high coefficients of variation) identified regions requiring more measurements, such as Alaska and the deserts of the U.S. Southwest. Our approach effectively captures the heterogeneous relationships between widely available predictors and the current SOC baseline across regions, offering reliable SOC estimates at 1 km resolution for benchmarking Earth system models.
Nucleus pulposus cells regulate macrophages in degenerated intervertebral discs via the integrated stress response-mediated CCL2/7-CCR2 signaling pathway
Authors: Tian Shuo , Chen Xuanzuo , Wu Wei , Lin Hui , Qing Xiangcheng , Liu Sheng , Wang BaiChuan , Xiao Yan , Shao Zengwu , Peng Yizhong 
Published: February 2024

AbstractLower back pain (LBP), which is a primary cause of disability, is largely attributed to intervertebral disc degeneration (IDD). Macrophages (MΦs) in degenerated intervertebral discs (IVDs) form a chronic inflammatory microenvironment, but how MΦs are recruited to degenerative segments and transform into a proinflammatory phenotype remains unclear. We evaluated chemokine expression in degenerated nucleus pulposus cells (NPCs) to clarify the role of NPCs in the establishment of an inflammatory microenvironment in IDD and explored the mechanisms. We found that the production of C-C motif chemokine ligand 2 (CCL2) and C-C motif chemokine ligand 7 (CCL7) was significantly increased in NPCs under inflammatory conditions, and blocking CCL2/7 and their receptor, C-C chemokine receptor type 2(CCR2), inhibited the inductive effects of NPCs on MΦ infiltration and proinflammatory polarization. Moreover, activation of the integrated stress response (ISR) was obvious in IDD, and ISR inhibition reduced the production of CCL2/7 in NPCs. Further investigation revealed that activating Transcription Factor 3 (ATF3) responded to ISR activation, and ChIP-qPCR verified the DNA-binding activity of ATF3 on CCL2/7 promoters. In addition, we found that Toll-like receptor 4 (TLR4) inhibition modulated ISR activation, and TLR4 regulated the accumulation of mitochondrial reactive oxygen species (mtROS) and double-stranded RNA (dsRNA). Downregulating the level of mtROS reduced the amount of dsRNA and ISR activation. Deactivating the ISR or blocking CCL2/7 release alleviated inflammation and the progression of IDD in vivo. Moreover, MΦ infiltration and IDD were inhibited in CCR2-knockout mice. In conclusion, this study highlights the critical role of TLR4/mtROS/dsRNA axis-mediated ISR activation in the production of CCL2/7 and the progression of IDD, which provides promising therapeutic strategies for discogenic LBP.
Identifying novel proteins for suicide attempt by integrating proteomes from brain and blood with genome-wide association data
Authors: Zhao Hao , Liu Yifeng , Zhang Xuening , Liao Yuhua , Zhang Huimin , Han Xue , Guo Lan , Fan Beifang , Wang Wanxin , Lu Ciyong 
Published: February 2024

AbstractGenome-wide association studies (GWASs) have identified risk loci for suicide attempt (SA), but deciphering how they confer risk for SA remains largely unknown. This study aims to identify the key proteins and gain insights into SA pathogenesis. We integrated data from the brain proteome (N = 376) and blood proteome (N = 35,559) and combined it with the largest SA GWAS summary statistics to date (N = 518,612). A comprehensive set of methods was employed, including Mendelian randomization (MR), Steiger filtering, Bayesian colocalization, proteome‑wide association studies (PWAS), transcript-levels, cell-type specificity, correlation, and protein-protein interaction (PPI) network analysis. Validation was performed using other protein datasets and the SA dataset from FinnGen study. We identified ten proteins (GLRX5, GMPPB, B3GALTL, FUCA2, TTLL12, ADCK1, MMAA, HIBADH, ACP1, DOC2A) associated with SA in brain proteomics. GLRX5, GMPPB, and FUCA2 showed strong colocalization evidence and were supported by PWAS and transcript-level analysis, and were predominantly expressed in glutamatergic neuronal cells. In blood proteomics, one significant protein (PEAR1) and three near-significant proteins (NDE1, EVA1C, B4GALT2) were identified, but lacked colocalization evidence. Moreover, despite the limited correlation between the same protein in brain and blood, the PPI network analysis provided new insights into the interaction between brain and blood in SA. Furthermore, GLRX5 was associated with the GSTP1, the target of Clozapine. The comprehensive analysis provides strong evidence supporting a causal association between three genetically determined brain proteins (GLRX5, GMPPB, and FUCA2) with SA. These findings offer valuable insights into SA’s underlying mechanisms and potential therapeutic approaches.
Extracellular vesicles as tools and targets in therapy for diseases
Authors: Kumar Mudasir A. , Baba Sadaf K. , Sadida Hana Q. , Marzooqi Sara Al. , Jerobin Jayakumar , Altemani Faisal H. , Algehainy Naseh , Alanazi Mohammad A. , Abou-Samra Abdul-Badi , Kumar Rakesh , Al-Shabeeb Akil Ammira S. , Macha Muzafar A. , Mir Rashid , Bhat Ajaz A. 
Published: February 2024

AbstractExtracellular vesicles (EVs) are nano-sized, membranous structures secreted into the extracellular space. They exhibit diverse sizes, contents, and surface markers and are ubiquitously released from cells under normal and pathological conditions. Human serum is a rich source of these EVs, though their isolation from serum proteins and non-EV lipid particles poses challenges. These vesicles transport various cellular components such as proteins, mRNAs, miRNAs, DNA, and lipids across distances, influencing numerous physiological and pathological events, including those within the tumor microenvironment (TME). Their pivotal roles in cellular communication make EVs promising candidates for therapeutic agents, drug delivery systems, and disease biomarkers. Especially in cancer diagnostics, EV detection can pave the way for early identification and offers potential as diagnostic biomarkers. Moreover, various EV subtypes are emerging as targeted drug delivery tools, highlighting their potential clinical significance. The need for non-invasive biomarkers to monitor biological processes for diagnostic and therapeutic purposes remains unfulfilled. Tapping into the unique composition of EVs could unlock advanced diagnostic and therapeutic avenues in the future. In this review, we discuss in detail the roles of EVs across various conditions, including cancers (encompassing head and neck, lung, gastric, breast, and hepatocellular carcinoma), neurodegenerative disorders, diabetes, viral infections, autoimmune and renal diseases, emphasizing the potential advancements in molecular diagnostics and drug delivery.