bluuebunny/crossref_metadata_2025_split huggingface dataset:
A novel location classification system for Crohn’s disease based on small bowel involvement: a better predictor of disease progression
Authors: Guo Huili , Tang Jian , Qin Xiusen , Lin Minzhi , Li Miao , Yang Qingfan , Huang Zicheng , Gao Xiang , Chao Kang 
Published: February 2024

Abstract

Background
Small bowel involvement is related to poor prognosis in Crohn’s disease (CD), which may be a potential marker to stratify patients with a high risk of progression. This study aimed to establish a novel location classification system for CD and to develop a predictive model for disease progression.

Methods
Consecutive patients with non-stricturing/non-penetrating CD were retrospectively included in the Sixth Affiliated Hospital, Sun Yat-sen University (Guangzhou, P. R. China) between January 2012 and January 2018. Patients were classified into two groups according to disease location: small bowel involvement group and isolated colon group. The primary outcome was disease progression to stricturing or penetrating phenotypes. Progression-free survival was estimated using Cox proportional hazards regression analysis and Kaplan–Meier method.

Results
A total of 463 patients were analysed, with a median follow-up time of 55.3 months. Patients with small bowel involvement had a higher risk of disease progression than those with isolated colon disease (hazard ratio = 1.998, P = 0.007), while no differences were found between Montreal location classification and disease progression. Median progression-free survival was higher in the isolated colon group than in the small bowel involvement group (84.5 vs 77.3 months, P = 0.006). Four independent factors associated with disease progression were identified: small bowel involvement, duration of onset of &gt;1 year, deep mucosal ulcer, and C-reactive protein levels of ≥10 mg/L (all P &lt; 0.05). The nomogram model based on these factors showed good performance in predicting disease progression, with a C-index of 0.746 (95% confidence interval, 0.707–0.785).

Conclusions
Classifying CD based on small bowel involvement and isolated colon was superior to the Montreal location classification for predicting disease progression.
Remagnetization of the Upper Permian–Lower Triassic limestones in the western Lhasa Terrane and its tectonic implications
Authors: Bian Weiwei , Jiao Xianwei , Wang Suo , Liang Jiacheng , Ma Jiahui , Ding Jikai , Zhao Hanqing , Yang Tianshui , Zhang Shihong , Wu Huaichun , Li Haiyan , Deng Chenglong 
Published: February 2024

SUMMARY
The drift history of the Lhasa terrane plays an essential role in understanding the tectonic evolution of the Bangong-Nujiang Tethyan Ocean and the Neo-Tethyan Ocean, as well as the evolutionary history of the Tibetan Plateau. Here, a combined rock magnetic, petrographic, and palaeomagnetic study is performed on the Upper Permian–Lower Triassic limestones (∼259–251 Ma) in the western Lhasa terrane. The site-mean direction for the 28 sites is Dg = 32.1°, Ig = 50.3°, kg = 47.9 and α95 = 4.0° in situ and Ds = 342.9°, Is = 32.7°, ks = 43.2 and α95 = 4.2° after tilt-correction, yielding a palaeopole at 68.9°N, 314.4°E with A95 = 4.3°, corresponding to a palaeolatitude of 18.0° ± 4.3°N. The fold tests are not significant because the sampling section shows monoclinic features with minor variations in their bedding attitudes. The palaeopoles for the directions before and after tilt-correction are compared with reliable Late Permian–Palaeogene palaeopoles obtained from the Lhasa terrane. Based on these comparisons, the studied limestones were remagnetized prior to tilting and this remagnetization most likely occurred during the Early Cretaceous. The depositional environment of the limestones may have changed from anoxic to suboxic and oxic during the Early Cretaceous, leading to the oxidation of iron sulphide to authigenic magnetite. Meanwhile, the Late Jurassic–Early Cretaceous convergence between the western Lhasa and Qiangtang terranes may have resulted in tectonic fluid migration and the formation of calcite veins and stylolites in the limestones. This is supported by the presence of small calcite veins and stylolites in some samples, as well as the fact that the framboidal oxides were formerly sulphides (mostly pyrite), implying that the majority of the iron oxides observed in the limestones were authigenic. These processes indicate that chemical remanent magnetization caused by the growth of magnetic minerals related to tectonic fluid migration was most likely the mechanism for the limestone remagnetization.
Siderophore of plant growth promoting rhizobacterium origin reduces reactive oxygen species mediated injury in Solanum spp. caused by fungal pathogens
Authors: Kumar Ravinsh , Singh Ashutosh , Shukla Ekta , Singh Pratika , Khan Azmi , Singh Naveen Kumar , Srivastava Amrita 
Published: February 2024

Abstract

Aims
The study aims to explore antifungal properties of bacillibactin siderophore produced by the plant growth-promoting rhizobacterium (PGPR) Bacillus subtilis against fungal phytopathogens Alternaria porri and Fusarium equiseti isolated from Solanum lycopersicum and Solanum melongena plants.

Methods and results
Alternaria porri and F. equiseti were isolated from infected plants of eggplant and tomato, respectively. A plate assay was employed to assess the effect of bacillibactin against the phytopathogens. The antifungal potential of the PGPR was evaluated by estimation of dry fungal biomass, visualization of cellular deformity using compound and scanning electron microscopy, antioxidative enzyme assay and analysis of membrane damage via using lipid peroxidation. Inductively coupled plasma atomic emission spectroscopy (ICP-AES) analysis was employed to investigate changes in intracellular iron content. The impact of bacillibactin on pathogenesis was evaluated by infecting detached leaves of S. lycopersicum and S. melongena plants with both the pathogens and treating the infected leaves with bacillibactin. Leaves were further investigated for ROS accumulation, extent of necrosis and cell death. Our findings revealed significant damage to the hyphal structure of A. porri and F. equiseti following treatment with bacillibactin. Biomass reduction, elevated antioxidative enzyme levels, and membrane damage further substantiated the inhibitory effects of the siderophore on fungal growth. ICP-AES analysis indicates an increase in intracellular iron content suggesting enhanced iron uptake facilitated by bacillibactin. Moreover, application of 1500 µg ml−1 bacillibactin on infected leaves demonstrated a substantial inhibition of ROS accumulation, necrosis, and cell death upon bacillibactin treatment.

Conclusions
This study confirms the potent antagonistic activity of bacillibactin against both the phytopathogens A. porri and F. equiseti growth, supporting its potential as a promising biological control agent for fungal plant diseases. Bacillibactin-induced morphological, physiological, and biochemical alterations in the isolated fungi and pathogen-infected leaves highlight the prospects of bacillibactin as an effective and sustainable solution to mitigate economic losses associated with fungal infections in vegetable crops.
Artificial intelligence predictive analytics in heart failure: results of the pilot phase of a pragmatic randomized clinical trial
Authors: Sideris Konstantinos , Weir Charlene R , Schmalfuss Carsten , Hanson Heather , Pipke Matt , Tseng Po-He , Lewis Neil , Sallam Karim , Bozkurt Biykem , Hanff Thomas , Schofield Richard , Larimer Karen , Kyriakopoulos Christos P , Taleb Iosif , Brinker Lina , Curry Tempa , Knecht Cheri , Butler Jorie M , Stehlik Josef 
Published: February 2024

AbstractObjectivesWe conducted an implementation planning process during the pilot phase of a pragmatic trial, which tests an intervention guided by artificial intelligence (AI) analytics sourced from noninvasive monitoring data in heart failure patients (LINK-HF2).Materials and methodsA mixed-method analysis was conducted at 2 pilot sites. Interviews were conducted with 12 of 27 enrolled patients and with 13 participating clinicians. iPARIHS constructs were used for interview construction to identify workflow, communication patterns, and clinician’s beliefs. Interviews were transcribed and analyzed using inductive coding protocols to identify key themes. Behavioral response data from the AI-generated notifications were collected.ResultsClinicians responded to notifications within 24 hours in 95% of instances, with 26.7% resulting in clinical action. Four implementation themes emerged: (1) High anticipatory expectations for reliable patient communications, reduced patient burden, and less proactive provider monitoring. (2) The AI notifications required a differential and tailored balance of trust and action advice related to role. (3) Clinic experience with other home-based programs influenced utilization. (4) Responding to notifications involved significant effort, including electronic health record (EHR) review, patient contact, and consultation with other clinicians.DiscussionClinician’s use of AI data is a function of beliefs regarding the trustworthiness and usefulness of the data, the degree of autonomy in professional roles, and the cognitive effort involved.ConclusionThe implementation planning analysis guided development of strategies that addressed communication technology, patient education, and EHR integration to reduce clinician and patient burden in the subsequent main randomized phase of the trial. Our results provide important insights into the unique implications of implementing AI analytics into clinical workflow.
In-person, video conference, or audio conference? Examining individual and dyadic information processing as a function of communication system
Authors: Han Jingjing , Cores-Sarría Lucía , Zhou Han 
Published: February 2024

Abstract
The wide use of virtual communication has raised a need to understand its effect on communication effectiveness and the ways its different forms influence users’ information processing. To that end, this study proposes the Dynamical Interpersonal Communication Systems Model and posits that the amount of information directly perceived affects individual and dyadic information processing. This proposition is tested by examining how visual information influences physiological patterns, known to underlie information processing, during in-person, video, and audio-only conferences. Results indicate that while audio-only communication sustained emotional intensity better, visual-based communication required less initial cognitive effort. Visual information in combination with physical presence (in-person communication) resulted in consistently lower cognitive effort and stronger synchronization of positive emotions, compared to contexts involving visual but without embodied information (video communication). This study shows the importance of investigating interpersonal communication simultaneously across multiple systems and at the intra- and inter-personal levels.
Lipoleiomyoma: a potential mimic of an ovarian dermoid cyst on MRI—a case report
Authors: El Hassouni Fatima , El Graini Soumaya , Sassi Samia , El Haddad Siham , Rouas Lamiaa , El Youssfi Mounia 
Published: February 2024

Abstract
Uterine lipoleiomyomas are rare variants of uterine leiomyomas which is composed of adipocytes and smooth muscle cells. In this report, we describe the case of a 39-year-old patient who presented with persistent, isolated pelvic pain. Ultrasonography showed an oval, well-defined left ovarian mass. Computed tomography (CT) scanning showed a predominantly-fatty mass with tissular components, no calcifications and heterogeneously enhanced after injection, suggesting initially a mature teratoma. Magnetic resonance imaging (MRI) findings revealed a latero-uterine mass, suggesting the presence of a left ovarian dermoid cyst with a potentially-malignant fleshy component. A subsequent pathology report revealed a lipoleiomyoma with cartilaginous metaplasia. Most notably, despite the fatty nature of the tumour and the use of MRI, the pedunculated appearance of the lipoleiomyoma observed intraoperatively mimicked a dermoid tumour even on imaging. Improved understanding of leiomyoma variants and secondary degenerative changes can help prevent misdiagnosis.
Influence of sources with a spectral peak in the detection of Cosmic Dawn and Epoch of Reionization
Authors: He Mengfan , Zheng Qian , Guo Quan , Shan Huanyuan , Zhu Zhenghao , Xie Yushan , Huang Yan , Zhao Feiyu 
Published: February 2024

ABSTRACT
Foreground removal is one of the biggest challenges in the detection of the Cosmic Dawn (CD) and Epoch of Reionization (EoR). Various foreground subtraction techniques have been developed based on the spectral smoothness of foregrounds. However, the sources with a spectral peak (SP) at megahertz may break down the spectral smoothness at low frequencies (&lt;1000 MHz). In this paper, we cross-match the GaLactic and Extragalactic All-sky Murchison Widefield Array (GLEAM) extragalactic source catalogue with three other radio source catalogues, covering the frequency range 72 MHz–1.4 GHz, to search for sources with spectral turnover. 4423 sources from the GLEAM catalogue are identified as SP sources, representing ≈3.2 per cent of the GLEAM radio source population. We utilize the properties of SP source candidates obtained from real observations to establish simulations and test the impact of SP sources on the extraction of CD/EoR signals. We statistically compare the differences introduced by SP sources in the residuals after removing the foregrounds with three methods, which are polynomial fitting, principal component analysis, and fast independent component analysis. Our results indicate that the presence of SP sources in the foregrounds has a negligible influence on extracting the CD/EoR signal. After foreground subtraction, the contribution from SP sources to the total power in the two-dimensional power spectrum within the EoR window is approximately 3–4 orders of magnitude lower than the CD/EoR signal.
A comparison of next-generation turbulence profiling instruments at Paranal
Authors: Griffiths R , Bardou L , Butterley T , Osborn J , Wilson R , Bustos E , Tokovinin A , Le Louarn M , Otarola A 
Published: February 2024

ABSTRACT
A six-night optical turbulence monitoring campaign has been carried at Cerro Paranal observatory in 2023 February and March to facilitate the development and characterization of two novel atmospheric site monitoring instruments – the ring-image next-generation scintillation sensor (RINGSS) and 24-h Shack Hartmann image motion monitor (24hSHIMM) in the context of providing optical turbulence monitoring support for upcoming 20–40 m telescopes. Alongside these two instruments, the well-characterized Stereo-SCIDAR and 2016-MASS-DIMM were operated throughout the campaign to provide data for comparison. All instruments obtain estimates of optical turbulence profiles through statistical analysis of intensity and wavefront angle-of-arrival fluctuations from observations of stars. Contemporaneous measurements of the integrated turbulence parameters are compared and the ratios, bias, unbiased root mean square error, and correlation of results from each instrument assessed. Strong agreement was observed in measurements of seeing, free atmosphere seeing, and coherence time. Less correlation is seen for isoplanatic angle, although the median values agree well. Median turbulence parameters are further compared against long-term monitoring data from Paranal instruments. Profiles from the three small-telescope instruments are compared with the 100-layer profile from the stereo-SCIDAR. It is found that the RINGSS and SHIMM offer improved accuracy in characterization of the vertical optical turbulence profile over the MASS-DIMM. Finally, the first results of continuous optical turbulence monitoring at Paranal are presented which show a strong diurnal variation and predictable trend in the seeing. A value of 2.65 arcsec is found for the median daytime seeing.
Management of adult patients with podocytopathies: an update from the ERA Immunonephrology Working Group
Authors: Mirioglu Safak , Daniel-Fischer Lisa , Berke Ilay , Ahmad Syed Hasan , Bajema Ingeborg M , Bruchfeld Annette , Fernandez-Juarez Gema M , Floege Jürgen , Frangou Eleni , Goumenos Dimitrios , Griffith Megan , Moran Sarah M , van Kooten Cees , Steiger Stefanie , Stevens Kate I , Turkmen Kultigin , Willcocks Lisa C , Kronbichler Andreas 
Published: February 2024

ABSTRACT
The histopathological lesions, minimal change disease (MCD) and focal segmental glomerulosclerosis (FSGS) are entities without immune complex deposits which can cause podocyte injury, thus are frequently grouped under the umbrella of podocytopathies. Whether MCD and FSGS may represent a spectrum of the same disease remains a matter of conjecture. Both frequently require repeated high-dose glucocorticoid therapy with alternative immunosuppressive treatments reserved for relapsing or resistant cases and response rates are variable. There is an unmet need to identify patients who should receive immunosuppressive therapies as opposed to those who would benefit from supportive strategies. Therapeutic trials focusing on MCD are scarce, and the evidence used for the 2021 Kidney Disease: Improving Global Outcomes (KDIGO) guideline for the management of glomerular diseases largely stems from observational and pediatric trials. In FSGS, the differentiation between primary forms and those with underlying genetic variants or secondary forms further complicates trial design. This article provides a perspective of the Immunonephrology Working Group (IWG) of the European Renal Association (ERA) and discusses the KDIGO 2021 Clinical Practice Guideline for the Management of Glomerular Diseases focusing on the management of MCD and primary forms of FSGS in the context of recently published evidence, with a special emphasis on the role of rituximab, cyclophosphamide, supportive treatment options and ongoing clinical trials in the field.
Effects of community-based educational video interventions on nutrition, health, and use of health services in low- and middle-income countries: systematic review and meta-analysis
Authors: Boynito Wanzahun Godana , Pauwels Nele S , Otayto Kusse , De Henauw Stefaan , Abbeddou Souheila 
Published: February 2024

Abstract

Context
Health education using videos has been promoted for its potential to enhance community health by improving social and behavior change communication.

Objective
To provide stakeholders in maternal and child health with evidence that can inform policies and strategies integrating video education to improve maternal, newborn, and child health.

Data sources
Five databases (MEDLINE, Embase, Scopus, Web of Science, and CENTRAL) were searched on January 28, 2022, and November 10, 2022 (updated search). Quantitative and qualitative studies conducted in low- and middle-income countries on the effects of video-based interventions on nutrition, health, and health service use were eligible. There was no restriction on time or language. Study selection was done in 2 stages and in duplicate.

Data extraction
A total of 13 710 records were imported to EndNote. Of these, 8226 records were screened by title and abstract using Rayyan, and 76 records were included for full-text evaluation.

Results
Twenty-nine articles (n = 12 084 participants) were included in this systematic review, and 7 were included in the meta-analysis. Video interventions improved knowledge about newborn care (n = 234; odds ratio [OR], 1.20; 95% confidence interval [CI], 1.04–1.40), colostrum feeding (n = 990; OR, 60.38; 95%CI, 18.25–199.78), continued breastfeeding (BF; n = 1914; OR, 3.79; 95%CI, 1.14–12.64), intention to use family planning (FP) (n = 814; OR, 1.57; 95%CI, 1.10–2.23), and use of FP (n = 864; OR, 6.55; 95%CI, 2.30–18.70). Video interventions did not result in reduced prelacteal feeding or improvement in early initiation of BF. The qualitative studies showed that video interventions were acceptable and feasible, with perceived impacts on communities.

Conclusion
This systematic review and meta-analysis indicated that video interventions improved knowledge of newborn care, colostrum feeding, and continuing BF, and the intention to use FP. Given the high levels of heterogeneity and inconsistency in reporting, more research with stronger designs is recommended.

Systematic review registration
PROSPERO registration no. CRD42022292190.
Association of the clinical components in the distal interphalangeal joint synovio-entheseal complex and subsequent response to ixekizumab or adalimumab in psoriatic arthritis
Authors: McGonagle Dennis , Kavanaugh Arthur , McInnes Iain B , Kristensen Lars Erik , Merola Joseph F , Strober Bruce , Bolce Rebecca , Lisse Jeffrey , Pustizzi Jennifer , Sapin Christophe , Ritchlin Christopher 
Published: February 2024

Abstract

Objectives
To assess the frequency of simultaneous distal interphalangeal (DIP) joint disease and adjacent nail psoriasis (finger unit) among patients with psoriatic arthritis (PsA) and compare the efficacy of the IL-17A antagonist ixekizumab (IXE) and the TNF-α inhibitor adalimumab (ADA).

Methods
This post hoc analysis evaluated the simultaneous occurrence of DIP joint involvement (tenderness and/or swelling) and adjacent nail psoriasis among patients with PsA from the SPIRIT-H2H (NCT03151551) trial comparing IXE to ADA. Among patients with simultaneous DIP joint involvement and adjacent nail psoriasis in ≥1 digit at baseline, treatment effects were assessed through week 52 for each affected finger unit; ‘finger unit’ defines the connected DIP joint and adjacent nail of an individual digit.

Results
A total of 354 patients had simultaneous DIP joint involvement and adjacent nail psoriasis in ≥1 finger unit at baseline. Among them, 1309 (IXE: 639; ADA: 670) finger units had baseline DIP joint tenderness and/or swelling and adjacent nail psoriasis. Proportions of affected finger units achieving complete resolution were significantly higher with IXE vs ADA as early as week 12 (38.8% vs 28.4%, P &lt; 0.0001) and at all post-baseline assessments through week 52 (64.9% vs 57.5%, P = 0.0055).

Conclusion
In this study cohort, patients with DIP joint involvement almost always had adjacent nail psoriasis. Greater resolution of DIP joint tenderness, swelling and adjacent nail psoriasis was achieved at all time points over 52 weeks through targeting IL-17A with IXE than TNF-α with ADA, which is noteworthy given prior comparable musculoskeletal outcomes for both drug classes.
Yield curve momentum
Authors: Sihvonen Markus 
Published: February 2024

Abstract
I analyze time series momentum along the Treasury term structure. Yield curve momentum is primarily due to changes in the level factor of yields. Because yield changes are partly induced by changes in the federal funds rate, yield curve momentum is related to post-FOMC (Federal Open Market Committee) announcement drift. The momentum factor is unspanned by the information in the term structure today and is hence inconsistent with standard term structure, macrofinance, and behavioral models. I argue that the results are consistent with a model with unpriced longer term dependencies.