bluuebunny/crossref_metadata_2025_split huggingface dataset:
Enhancing supply chain management in the physical internet: a hybrid SAGA approach
Authors: Yan Weiqi , Li Nan , Zhang Xin 
Published: December 2023

AbstractThis paper introduces an advanced inventory replenishment optimization approach tailored for the Physical Internet (PI), addressing the dynamic and complex nature of this environment. We propose a hybrid Simulated Annealing–Genetic Algorithm (SA–GA), engineered to optimize the balance between exploration and exploitation, ensuring adaptability and efficiency in a variety of PI contexts. The study also presents an enriched mathematical model integrating dynamic demand, and multi-objective optimization. The SA–GA algorithm emerges as a novel contribution, characterized by its computational efficiency and adaptability, marking an advancement in PI inventory management. The incorporation of real-time data analytics in our dynamic inventory replenishment strategy enhances adaptability and responsiveness, while the robust mathematical model offers a versatile tool for both theoretical analysis and practical application. Collectively, these innovations help bridge existing gaps in PI inventory management and serve as a reference for other similar studies.
Contrasting structures of the Southern Benue trough and the contiguous crystalline basement as observed from high-resolution aeromagnetic data
Authors: Adebiyi Leke Sunday , Eluwole Akinola Bolaji , Fajana Akindeji Opeyemi , Salawu Naheem Banji , Saleh Aliyu 
Published: December 2023

AbstractThe present study investigated crustal structures and geological bodies within selected areas of the southern Benue trough and the adjacent crystalline basement. It utilized high-resolution aeromagnetic data to provide original insights into the contrasting structures and geological bodies within the area, while also identifying promising areas for further mineral and hydrocarbon investigations. The aeromagnetic anomaly data were analyzed using various techniques, including total gradient magnitude, pseudo-gravity transformation, tilt derivative, and source parameter imaging. The total gradient magnitude anomalies revealed a considerable component of the basin affected by block faulting which may have resulted from severe tectonic and structural deformation of the metamorphic basement and the subsequent injection into the sedimentary sequence, a few intrusions. The pseudo-gravity transformation identified a large igneous body in the sedimentary basin which is characterized by positive pseudo-gravity anomalies and surrounded on both sides by linear negative anomalies that signify a rift zone. The positive amplitude of the tilt derivative identified subtle linear magnetic minerals associated with the geologic structure and igneous bodies that suggest considerable mineral exploration prospects. A two-dimensional model of the source parameter imaging reveals the basement below the sedimentary basin to be intensely fragmented and variably subsided with the floor of the basin forming irregular upward and downward folds. In conclusion, the findings suggest promising prospects for mineral exploration along the margin of the sedimentary basin and potential hydrocarbon resources in the northeastern segment of the basin, which is characterized by fewer intrusions.
A Matter of Time: A Web-Based Investigation of Rest and Sleep Effects on Speech Motor Learning
Authors: van Zelst Anne L. , Earle F. Sayako 
Published: December 2023

Purpose:
Here, we examine the possibility that memory consolidation during a period of postpractice rest or nocturnal sleep can bolster speech motor learning in the absence of additional practice or effort.

Method:
Using web-administered experiments, 74 typical, American English talkers trained in a nonnative vowel contrast then had a 12-hr delay with (SLEEP) or without nocturnal sleep (REST) or proceeded immediately (IMMEDIATE) to a posttraining production assessment. For ecological validity, 51 native Danish talkers perceptually identified the American English talkers' productions.

Results:
We observed that practice resulted in productions that were more acoustically similar to the Danish target. In addition, we found that rest in the absence of further practice reduced the token-to-token variability of the productions. Last, for vowels produced immediately following training, listeners more accurately identified vowels in the trained context, whereas in the untrained context, listener accuracy improved only for vowels produced by talkers who slept.

Conclusions:
A single session of speech motor training promotes observable change to speech production behavior. Specifically, practice facilitates acoustic similarity to the target. Moreover, although a 12-hr postpractice period of rest appears to promote productions that are less variable, only the productions of those who slept are perceived as more accurate by listeners. This may point to sleep's role in contextualizing the acoustic goal of the production to the learner's own vocal tract and its role as a protective mechanism during learning. These results are unaccounted for under existing models and offer potential for future educational and clinical applications to maximize speech motor learning.

Supplemental Material:

https://doi.org/10.23641/asha.24707442
Quantification of skin wound tension using a newly designed wound
tensiometer
Authors: Lackmann Felix , Rohwedder Thomas , Maron Anita , Stegen Ludo , Brunnberg Mathias , Brunnberg Leo , Burger Michael , Böttcher Peter 
Published: December 2023

Abstract
Objective To (i) quantitatively measure wound tension in experimental skin
wounds using a newly developed wound tensiometer and (ii) establish reference
values for primary skin wound closure in medium- and large-breed dogs.
Study design Experimental cadaveric study.
Animal population Nineteen dogs of medium to large breeds (BW 20 to
40 kg).
Methods Elliptical skin wounds of different sizes were created on the
chest and abdomen. The wounds were gradually enlarged. Experienced surgeons
(ECVS diplomates or professors of small animal surgery) and inexperienced
surgeons (1st year after graduation) independently assessed wound tension
through manual manipulation and determined whether the wound could be closed
without tension-relieving measures. In addition, wound tension was objectively
quantified using a newly developed wound tensiometer.
Results The upper threshold for wound tension at which direct appositional
wound closure was recommended by the experienced surgeons was 5.4 N, and
the median minimal tension without recommendations for closure was
6.0 N. The data also demonstrate that wound tension and wound size do
not necessarily correlate, and inexperienced surgeons need to develop a feel for
wound tension.
Conclusion The intraoperative use of the wound tensiometer, in combination
with established cut-off values, might facilitate decision-making regarding
primary wound closure.
Clinical relevance The findings of this study provide evidence for the
applicability of a wound tensiometer in guiding inexperienced surgeons in their
choice of the skin wound closure method.
Ein Update zur felinen und caninen Giardiose
Authors: Kanski Sabrina , Weber Karin , Busch Kathrin 
Published: December 2023

Zusammenfassung
Giardia duodenalis ist ein fakultativ pathogener Darmparasit. Die
Giardiose bei Hund und Katze kann symptomatisch oder asymptomatisch verlaufen,
wobei typische Symptome Durchfall mit und ohne Erbrechen sind. Die
Prävalenz bei Jungtieren ist hoch und kann bis zu 50 % betragen.
Es gibt 8 verschiedene Genotypen (A–H), welche als Assemblages
bezeichnet werden. Bei Hunden kommen am häufigsten die Assemblages C und
D und bei Katzen die Assemblages F und A vor. Tiere können somit auch
mit den zoonotischen Assemblages A und B oder auch mit mehreren Genotypen
gleichzeitig infiziert sein. Als Diagnostikmethoden werden der
Immunfluoreszenztest (IFA), der Enzymimmunoassay (ELISA) und die
Fäkalzentrifugation mittels Zinksulfatlösung empfohlen. Mittels
Polymerasekettenreation (PCR) kann die entsprechende Assemblage bestimmt werden.
Zur Therapie der caninen und felinen Giardiose sind die Wirkstoffe Fenbendazol
und Metronidazol zugelassen. Zudem sollten bestimmte Hygienemaßnahmen
beachtet werden. Behandelt werden nur symptomatische Tiere oder solche, welche
im selben Haushalt mit Risikopatienten (z. B. immunsupprimierten
Menschen) leben. Ziel der Behandlung ist die klinische Verbesserung der
Symptomatik der erkrankten Hunde und Katzen. Zu einer vollständigen
Elimination der Giardien kommt es oftmals nicht.
LncRNA H19 Influences Cellular Activities via the
miR-454-3p/BHLHE40 Axis in Anaplastic Thyroid Carcinoma
Authors: Wu Yang , Yang Jihua , Zhang Honglai , Cheng Jingjing , Lei Peijie , Huang Jianyuan 
Published: December 2023

AbstractAnaplastic thyroid carcinoma (ATC) is an aggressive malignancy threatening
patients’ life quality. Our previous study has demonstrated that
inhibition of long non-coding RNA H19 (lncRNA h19; H19) blocks ATC growth and
metastasis. The current study aimed to further explore the potential mechanism
of H19 in ATC. Expression of H19, miR-454-3p, and BHLHE40 mRNA was measured
using RT-qPCR in tissue samples and cell lines. The dual-luciferase reporter
assay and Pearson correlation analysis were used to explore the interaction
among H19, miR-454-3p, and BHLHE40. The biological process of proliferation,
migration, and invasion was determined using loss- or gain-function CCK-8 and
Transwell assays. Western blot assay was used to evaluate the changes in protein
levels. H19 was elevated in ATC tissues and cell lines. Based on online
prediction database results, miR-454-3p might be a target of H19, and BHLHE40
might be a direct target of miR-454-3p. miR-454-3p expression was decreased in
ATC and had a negative interaction with H19. BHLHE40 mRNA expression was
increased and has a negative correlation with miR-454-3p and a positive
correlation with H19. Downregulation of miR-454-3p and upregulation of BHLHE40
could reverse the decreased cellular activities caused by si-H19. Moreover, the
silence of H19 modulates BHLHE40 to affect the PI3K/AKT protein levels
and apoptotic-related protein levels. The current study provided a potential
detailed mechanism of H19 in ATC, and lncRNA H19-miR-454-3p-BHLHE40 interaction
may be a new experimental basis for prognosis and targeted therapy for ATC
patients.
Adjuvante Behandlung des caninen Hämangiosarkoms der Milz mit
der autologen dendritischen Zelltherapie – eine prospektive,
placebokontrollierte, randomisierte Doppelblindstudie
Authors: Reck Amalia , Gedon Julia , Kessler Martin 
Published: December 2023

Zusammenfassung
Gegenstand und Ziel Hämangiosarkome (HSA) der Milz beim Hund sind
hochmaligne mesenchymale Tumoren, die eine hohe Metastasierungsneigung
aufweisen. Auch mit adjuvanter Chemotherapie nach der Splenektomie liegen die
medianen Überlebenszeiten i.d.R. bei lediglich 5–8 Monaten. Ziel
dieser Studie war, anhand einer prospektiven randomisierten Doppelblindstudie
nach der Splenektomie die Wirksamkeit einer adjuvanten dendritischen
Zelltherapie nach der PetBioCell-Methode zu überprüfen. Zudem
wurden mögliche unerwünschten Wirkungen dieser Therapie
evaluiert.
Material und Methoden Einundzwanzig Hunde mit histologisch nachgewiesenem,
nicht-metastasiertem HSA der Milz (Stadium I und II) nach Splenektomie wurden in
die Studie inkludiert. Zehn Hunde erhielten die dendritische Zelltherapie, 11
Hunde bekamen ein Placebo injiziert. Die Applikation erfolgte nach
Herstellerangaben in den ersten 3 Monaten monatlich, anschließend alle 3
Monate bis zum Tod der Patienten. Die Überlebenszeiten sowie die
unerwünschten Wirkungen beider Gruppen wurden verglichen.
Ergebnisse Der Follow-up aller Patienten reichte bis zur Euthanasie oder
Versterben aufgrund von Metastasen. Ein Patient aus der Gruppe mit der
dendritischen Zelltherapie wurde aufgrund einer Prostatitis euthanasiert, dieser
hatte die längste Überlebenszeit (668 Tage). Ein Hund aus der
Placebo-Gruppe überlebte 448 Tage nach Splenektomie. Die mediane
Überlebenszeit betrug bei der dendritischen Zelltherapie-Gruppe 74 Tage,
bei der Placebo-Gruppe 126 Tage. Statistisch zeigte sich in der Tumor-freien
Zeit (t(18) = 1,4, p = 0,911) und der Überlebenszeit
(t(19) = –0,094, p = 0,463) zwischen den beiden Gruppen
kein Unterschied. Alle unerwünschten Wirkungen waren in der
Therapiegruppe mild und selbstlimitierend, auch in der Placebo-Gruppe wurde von
ähnlichen milden unerwünschten Wirkungen berichtet.
Schlussfolgerung und klinische Relevanz Die Immuntherapie mit autologen,
unreifen und ungeprimten dendritischen Zellen nach der PetBioCell-Methode zeigte
beim kaninen Hämangiosarkom der Milz in dieser Studienpopulation keine
nachweisbare Wirksamkeit hinsichtlich der Tumor-freien Zeit und
Überlebenszeit.
Zwerchfellhernie bei einer Alpakastute (Vicugna pacos)
Authors: Wagener Matthias Gerhard , Kammeyer Patricia , Kleinschmidt Sven , Neubert Saskia , Ganter Martin 
Published: December 2023

ZusammenfassungEine 3-jährige hochträchtige Alpakastute fiel nach der Schur durch vermehrtes Liegen und verminderte Futteraufnahme auf. Zwölf Tage nach der Schur kam es zum Abort eines fast vollständig entwickelten Fohlens. Nach weiteren 2 Tagen kam die Stute zum Festliegen und verendete anschließend während des Transports in die Klinik. In der Sektion des Tierkörpers konnte eine Zwerchfellhernie festgestellt werden. Zwerchfellhernien wurden bei vielen Tierarten beschrieben, die Diagnose kann mittels Röntgen oder Ultraschall gestellt werden. Je nach Ausmaß kann eine chirurgische Therapie erfolgreich sein.
Chloroquine Alleviates Atherosclerosis by Modulating Regulatory T
Cells Through the ATM/AMPK/mTOR Signaling Pathway in
ApoE
−/−
Mice
Authors: Liu Dan , Zhang Yonggang , Zhang Yiyi , Huang Qiaorong , Meng Wentong , Gao Jinhang , Mo Xianming , Tian Haoming , Li Sheyu 
Published: December 2023

Abstract
Background Clinical observation suggests the atheroprotective effect of
chloroquine and its derivatives, while its mechanism remains unclear. This study
aimed to observe the protective effect of chloroquine against atherosclerosis
and explore the underlying mechanism.
Methods Ataxia telangiectasia mutated (ATM) wild-type or haploinsufficient
apolipoprotein-E-knockout
(ATM+/+ApoE−/−
or
ATM+/−ApoE−/−)
mice were treated with different dosages of chloroquine. Anti-CD25 antibody was
used to deplete natural Tregs in
ATM+/+ApoE−/−
mice. The atherosclerotic burden in different groups of mice was comprehensively
evaluated by H&E staining and Masson staining. The effect of chloroquine
on the regulatory T cells (Tregs) was assessed in vivo and in vitro by flow
cytometry and immunohistochemical staining. The expression of related proteins
was detected by real-time polymerase chain reaction and western blotting.
Results In
ATM+/+ApoE−/−
mice, chloroquine alleviated atherosclerotic lesions, stabilized the plaque, and
increased Treg counts in the atherosclerotic lesions and spleens. However, in
ATM haploinsufficient mice
(ATM+/−ApoE−/−),
chloroquine no longer prevented atherosclerosis or impacted Treg counts.
Abolishing Treg cells using an anti-CD25 antibody in vivo abrogated the
atheroprotective effect of chloroquine. In vitro, chloroquine promoted the
differentiation of Tregs from naïve T cells, which was accompanied by
enhanced ATM/AMP-activated protein kinase (AMPK) activity and reduced
downstream mammalian target of rapamycin (mTOR) activity.
Discussion These findings suggest that chloroquine ameliorates
atherosclerosis and stabilizes plaque by modulating Tregs differentiation
through the regulation of the ATM/AMPK/mTOR pathway.
Head and Neck Injuries among Powered Scooter Users between 2010 and 2019
Authors: Trapp Luke P. , Sukumar Nitin , Cristel Robert T , Yu Jeffrey 
Published: December 2023

AbstractPowered scooters, including electric scooters (e-scooters), have become an increasingly available and popular mode of personal transportation, but the health risks of these devices are poorly explored. We aim to quantify the increase in frequency of powered scooter–associated head and neck region injuries occurring yearly from 2010 to 2019, and to compare the frequency and severity of injury with those involving unpowered scooters. Here we present a retrospective cross-sectional study of all patients with head and neck injuries associated with powered and unpowered scooters seen in emergency departments reporting to the National Electronic Injury Surveillance System (NEISS) database from January 1, 2010 to December 31, 2019. During this time frame, a total of 1,620 injuries associated with powered scooters and a total of 5,675 injuries associated with unpowered scooters were reported to the NEISS. The database estimates these to reflect a nationwide total of 54,036 powered scooter–related injuries and 168,265 unpowered scooter–related injuries. Powered scooter injuries have increased for both children and adults since 2014, and estimated powered scooter injuries (16,243) surpassed estimated unpowered scooter injuries (14,124) when including all age groups for the first time in 2019. In 2019, adults are estimated to have nearly twice as many powered scooter–related head and neck injuries as children (10,884 vs. 5,359, respectively). In 2019, a higher proportion of powered scooter–related injuries involving adults were severe injuries when compared with those involving children (13.3 vs. 5.2%, respectively). Interestingly, unpowered scooters still cause many more estimated injuries in children than powered scooters did during 2019 (11,953 vs. 5,083). We find that powered scooters are now associated with a greater number and severity of head and neck injuries among the adult population than the pediatric population. But unpowered scooters still cause more head and neck injuries than powered scooters in the pediatric population.
Bridging the Gap: A Pilot Study on the Efficacy of Nerve Allografts in Autologous Breast Reconstruction
Authors: Lu Wang Marcos , Huang Hao , Zhang Ashley , Ellison Angela , Black Grant G. , Otterburn David M. 
Published: December 2023

Abstract
Background Breast anesthesia is commonly reported after mastectomy and reconstruction. During deep inferior epigastric perforator (DIEP) flap reconstruction, we coapt at least one of the T10 to T12 thoracoabdominal nerves within the flap to the anterior cutaneous branch of the third intercostal nerve using a nerve allograft. We aim to evaluate the efficacy of nerve grafting in improving sensory recovery following neurotized DIEP flap reconstruction.
Methods Thirty patients (54 breasts) underwent immediate neurotized DIEP flap reconstruction using nerve grafts. Sensitivity evaluation was performed in nine breast regions. For each patient, sensation was compared between two time points: 3 to 6 months postoperatively versus 12 to 24 months postoperatively. The reconstructive BREAST-Q was used to survey patients' satisfaction of their breasts, physical well-being, psychosocial well-being, and sexual well-being.
Results At 3 to 6 months postoperatively, patients had a mean sensitivity measurement of 52.1 g/mm2. At 12 to 24 months postoperatively, patients had a mean sensitivity measurement of 40.3 g/mm2. There was a significant decrease in the mean cutaneous threshold required for patients to perceive sensation between the two time points (–29.1%, p = 0.041). On the reconstructive BREAST-Q, patients scored significantly higher in breast satisfaction (56.7/100 vs. 75.1/100, 32.5%, p = 0.032) and physical well-being (66.0/100 vs. 85.5/100, 20.2%, p = 0.022) between the two time points.
Conclusion Patients who undergo nerve graft-based DIEP flap reconstruction can expect significant improvements in sensation to pressure over time. This improvement found on sensory testing correlates with significant improvement in patients' BREAST-Q scores.
Regio- and Stereoselective Synthesis of 2′-Deoxy-4′-thioguanine Nucleosides: Evaluation of Anti-Hepatitis B Virus Activity and ­Cytotoxicity Leading to Improved Selectivity Index by 4′-C-Cyanation
Authors: Haraguchi Kazuhiro , Kumamoto Hiroki , Imoto Shuhei , Kuwata-Higashi Nobuyo , Mitsuya Hiroaki 
Published: December 2023

AbstractAn N
9-regio- and β-anomer-selective 4′-thioglycosidation of purine bases has been developed. The reaction between a 2-deoxy-2-iodo-4-thioribofuranosyl glycosyl donor and N-(6-chloro-9H-purin-2-yl)-2-methylpropanamide gave the corresponding 2′-deoxy-4′-thiopurine nucleoside in 87% yield along with its N
7-regioisomer in 6% yield, without the formation of the α-anomer. By using a derivative obtained from 17, a practical chemical synthesis of 2′-deoxy-4′-thioguanosine was developed. 4′-α-C-Cyano-2′-deoxy-4′-thioguanosine was synthesized, starting from a 4-(acetoxymethyl)-2-deoxy-2-iodo-4-thioribofuranose derivative as a glycosyl donor. An evaluation of the anti-hepatitis B virus (HBV) activity and the cytotoxicity toward the host cell revealed that 4'-C-cyano-2'-deoxy-4'-thioguanosine exhibited about 100 times more potent anti-HBV activity than 2′-deoxy-4′-thioguanosine with a comparative cytotoxicity, resulting in the identification of a novel molecule having better selectivity index value than that of 2′-deoxy-4′-thioguanosine. This finding might provide a guideline for the development of the next generation of anti-HBV agents.
X-ray fluorescent method for the analysis of trace elements in bio-materials with correction of the matrix effect
Authors: Mikhailov Igor F. , Mikhailov Anton I. , Borisova Svetlana S. , Fomina Larisa P. 
Published: December 2023

A method for correcting the matrix effect by measuring the intensity of fluorescent radiation and its absorption by the sample material in the same x-ray optical scheme is proposed. The use of a complex secondary Ag–Ge emitter as a primary radiation source provides a low detection limit for a wide range of chemical elements from Ca (Z = 20) to Mo (Z = 42) in the K-series and from Cd (Z = 48) to Bi (Z = 83) in the L-series. To measure the absorption, the radiation of an additional secondary emitter is used, of which the wavelength can be varied in the range from 0.633 to 3.38 Å, depending on the measured impurity. An example of determining the mass fraction of an impurity in a sample of unknown composition prepared from a mixture of state standard samples of aqueous solutions is given. The x-ray optical scheme was assembled on the basis of a portable Energy Dispersive X-ray Fluorescence (EDXRF) spectrometer. The method is designed to study materials with a base consisting of chemical elements with a low atomic number.
Preliminary investigation on the implementation of an artificial synapse using TaOx-based memristor with thermally oxidized active layer
Authors: Kim Juri , Park Yongjin , Lee Jung-Kyu , Kim Sungjun 
Published: December 2023

This study presents a preliminary exploration of thermally oxidized TaOx-based memristors and their potential as artificial synapses. Unlike the 10-min annealed devices, which display instability due to current overshoots, the 5-min annealed device exhibits stable resistive switching, retention, and endurance characteristics. Moreover, our memristor showcases synaptic behaviors encompassing potentiation, depression, spike-timing-dependent plasticity, and excitatory postsynaptic currents. This synaptic emulation holds tremendous promise for applications in neuromorphic computing, offering the opportunity to replicate the adaptive learning principles observed in biological synapses. In addition, we evaluate the device’s suitability for pattern recognition within a neural network using the modified National Institute of Standards and Technology dataset. Our assessment reveals that the Pt/TaOx/Ta memristor with an oxidized insulator achieves outstanding potential manifested by an accuracy of 93.25% for the identical pulse scheme and an impressive accuracy of 95.42% for the incremental pulse scheme.