bluuebunny/crossref_metadata_2025_split huggingface dataset:
Knowledge of periodontal diseases, oral hygiene practices, and self-reported periodontal problems among patients visiting a tertiary dental care centre in Trivandrum, Kerala
Authors: Sasi Anoop , Suchitra A , Kumar Santhosh S , Ramesh Roshni , Mohamed Shahana C 
Published: December 2023

: The prevalence of periodontal diseases is increasing globally. This can be attributed to the deficits in the health care system, especially in educating the public about periodontal diseases, and oral hygiene practices. This issue is more severe among people living in remote and rural areas where accessibility to dental health care education is difficult. This study aims to assess the oral hygiene practices, knowledge of periodontal diseases, and self-reported periodontal problems among adults visiting the tertiary dental care centre in Trivandrum, Kerala: This cross-sectional study employed a pretested and validated questionnaire to assess the three main constructs of periodontal knowledge, practices, and self-reported periodontal health issues among adults aged more than 18 years. All the patients who visited the outpatient department of periodontology at Government Dental College, who gave informed consent were administered the questionnaire.: Two hundred and twenty-nine study participants responded with a slight female gender predilection. 89.1% reported periodontal health problems. Good knowledge of periodontal diseases and oral hygiene practices was seen among 48.5% and 44.1% of the study respondents. Rural residents were found to be at a higher risk of poor periodontal knowledge and oral hygiene practices, and more self-reported periodontal health issues. The level of education also showed a significant association with periodontal knowledge and practices.: The findings of the study shed light on the need for devising effective educational interventions to improve the periodontal knowledge and practices of adults. Incorporating health promotional interventions into the clinical treatment regime, designing a hospital setting-based intervention with the help of house surgeons and post-graduates, and reinforcement of health education at regular intervals were a few recommendations to enhance the knowledge, practices and the oral health care seeking nature of general population.
A CHARACTERIZATION OF WEAKLY REGULAR LINEAR FUNCTIONALS
Authors: Marcellán Francisco , Sfaxi Ridha 
Published: December 2023

A linear functional is said to be weakly-regular if it is not a finite sum of Dirac masses and their derivatives. In this paper, we consider the first-order linear differential equations (Eu)'+Fu=0 where u is a non-zero linear functional and (E,F) is a pair of polynomials, with E monic. The aim of this work is to give weak-regularity conditions on u. Under certain admissibility conditions of the pair (E, F), the weak-regularity of u leads to its regularity. Some examples are analyzed.
PERMUTATION POLYNOMIALS IN ONE INDETERMINATE OVER MODULAR ALGEBRAS
Authors: Acosta-Solarte Pablo A. , Albis Víctor S. 
Published: December 2023

Known results about permutation polynomials in connection with coefficients in a finite field extend to algebras of the form Lv = K[X]/(p(X)v)\), where K is a finite field,(p(X) ∈ ‍ K[X] is an irreducible polynomial, and v = 1,2,..., and to the algebra of power series L[[Z]], where L = K[X]/(p(X)). Analogues of Dickson polynomials are also studied in this context.
ESCALA DE INFORMACIÓN, ESCALA DE FLUCTUACIÓN Y ENTROPÍA DE LAS LLUVIAS EN EL VALLE DE ABURRÁ, COLOMBIA
Authors: Poveda Germán 
Published: December 2023

Presentamos dos parámetros estadísticos nuevos para el estudio de series de tiempo de variables geofísicas, que denominamos escala de información ψ*, y escala de información normalizada ψ, útiles para cuantificar la dependencia global (no lineal) y a memoria de los procesos geofísicos en el tiempo. Estos nuevos parámetros constituyen una generalización de la escala de fluctuación, θ, que cuantifica la dependencia lineal y la persistencia en procesos de memoria corta. Definimos la escala de información como la integral de la función de autocorrelación. Estimamos las funciones de auto-información, análoga a la escala de fluctuación que se define como la integral de la función de autocorrelación. Estimamos las funciones de auto-información y de autocorrelación usando registros de lluvias en estaciones localizadas en el Valle de Aburrá sobre la cordillera central de Los Andes de Colombia, con una resolución temporal de 15 min. Durante el período de 1998-2006. Estimamos tanto la escala de información como la escala de fluctuación, y estudiamos cómo se comporta la entropía de las series de lluvia cuando la lluvia se agrega intervalos de tiempo crecientes T= 15 - 30 min., así como 1, 3, 6, 12, y 24 horas. Los resultados indican que la entropía y las escalas de información son levemente dependientes del número de intervalos de clase requeridos para estimar la función de distribución de probabilidades del proceso estocástico.
Encontramos que las funciones de autocorrelación y de auto-información exhiben un patrón de decaimiento muy rápido (exponencial), lo cual implica convergencia de escala de fluctuación a en el rango θ ∈ (58 min.-93 min.), y de la escala de información ψ ∗ ∈ (5 min – bits a 16 min – bits). Además, la relación entre las escalas de información normalizada exhibe valores en el rango ψ ∈ (39 min. – 56 min.). Además, la relación entre las escalas de fluctuación y de información exhibe valores φ = θ/ψ∗ ∈ (1,41 − 1,79). Finalmente, encontramos que la entropía crece como una función potencial casi perfecta del intervalo de agregación temporal, tal que S ∼ Tβ, with β ∈ (0,533 – 0,758). Este resultado debería explicarse en términos de la ganancia de información sobre la lluvia a medida que transcurre el tiempo, pero que también debería poder ser explicado como consecuencia de la segunda ley de la termodinámica en la lluvia tropical de montaña.
Legal Consequences of Authentic Deed Made by Notary after Declared Bankruptcy
Authors: Nita NurJanah Dian 
Published: December 2023

AbstractThis research aims to analyze legal consequences of an authentic deed by Notary after being declared bankruptcy. The research method used is juridical normative. The data source is secondary data. The data analysis method used qualitative nomative. The result of this research are normatively in the Law of Notary Position that Notary declared bankrupt based on court decision that has obtained permanent legal force will dishonorable dismissal. A Notary is decraled bankrupt has legal consequences against the deed the made to lose authenticity. So, the authentic deed only has strenght evidence the private deed.Keywords: Notary; Legal consequences; Authentic; bankruptcy.
Formulation, Characterization, and Sunscreen Potential Evaluation of Nutmeg Leaf Essential Oil Nanoemulsions (Myristica fragrans Houtt.)
Authors: Rastuti Undri , Widyaningsih Senny , Chasani Mochammad , Habibie Ranti Kamila , Elly Vani Fitria Rosita , Zia Sity Khalidah 
Published: December 2023

Nutmeg leaf essential oil (Myristica Fragrans Houtt.) is one of the natural ingredients which have antioxidant activity and potential as a sunscreen. The research aims to formulate nutmeg leaf essential oil nanoemulsion, characterize, and determine its potency as a sunscreen. Nutmeg leaf essential oil nanoemulsion was formulated with 1; 3; and 5 mL of oil content with two variations of surfactant. The characterization included organoleptic, pH, viscosity, %T, nanoemulsion type, droplet size, thermodynamic and centrifugation stability tests. Evaluation was conducted using UV-Vis spectrophotometer at a wavelength range of 290-400 nm with ethanol as a blank and non-nano-emulsified as a comparison. The result showed that the nutmeg leaf essential oil nanoemulsion had clear and stable appearance, safe for skin, viscosity values of <200 mPas, %T values of near 100%, nanoemulsions type of o/w, and particles size of <200 nm. The evaluation showed that the sunscreen activities of nutmeg leaf oil nanoemulsion was higher than non-nano-emulsified. The highest sunscreen activity was the formula A nanoemulsion which an oil content of 5 mL and had an SPF value of 1.475; %Te value of 50.571%; and %Tp value of 77.218%. The nanoemulsion sunscreen activity of formula A was categorized as a regular suntan
Extract of Rhoeo Discolor Leaf as a Reducing and Stabilizing Agent in the Synthesis of Silver Nanoparticles
Authors: Gusrizal Gusrizal , Sayekti Endah , Radianti Sri 
Published: December 2023

Silver nanoparticles (AgNPs) have been synthesized using Rhoeo discolor leaf extract as a reducing and stabilizing agent. AgNPs were synthesized by adding silver nitrate to the extract of Rhoeo discolor and incubating it in a boiling water bath. The change in color of the mixture from clear to yellow indicated AgNPs formation. The synthesized AgNPs were spherical and showed an absorption peak at around 410-420 nm. The size of particles was distributed from 92 to 485 nm with an average size of 176 nm, and the polydispersity index was 0.185. The stability test showed that synthesized AgNPs were stable for three months of storage at ambient temperature. The extract of Rhoeo discolor were responsible for reducing silver ion and stabilizing the synthesized AgNPs.
Steroid profile and ovarian gene expression in Genyatremus luteus (Teleostei, Perciformes: Haemulidae) during sexual maturation
Authors: Ribeiro Diego Luiz dos Santos , Ribeiro Larissa Sarmento dos Santos , Silva João Mandu da , Noleto Katherine Saldanha , Bezerra Nancyleni Pinto Chaves , Souza Fernando Almeida , Carvalho-Neta Alcina Vieira de , Torres Junior José Ribamar de Souza 
Published: December 2023

The aim of the present study was to assess histological features, sex steroid profile, and ovarian gene expression throughout the ovarian maturation of Genyatremus luteus in Brazilian Coastal Equatorial Amazon. Specimens were categorized into different gonadal maturation stages–immature (n = 7), maturing (n = 7), mature (n = 7), and spawned (n = 7)–based on histological features of ovarian follicles and on oocyte development. Plasma E2, 11-KT and 17α-OHP levels were measured through enzyme-linked immunosorbent assays. The gene expression of estrogen (er) and LH (lhr) receptors in the ovary was analyzed through real-time polymerase chain reaction. The highest plasma E2 concentration was found in mature specimens (P< 0.05). Plasma 17α-OHP concentrations have significantly increased from the immature to the final maturation stage (P< 0.05). Maturational reproductive stage did not have any effect on plasma 11-KT concentrations. Er expression in ovaries has significantly increased throughout ovarian maturation (P < 0.05), and it remained high at mature and spawned stages. Lhr expression showed similar trend throughout the maturation process, although its peak was observed at spawned stage (P< 0.05). In conclusion, the gene expression profile of er and lhr and plasma E2 and 17α-OHP concentrations are proportional to oocyte development; they play important role in regulating ovarian development and ovulation in G. luteus.
Molecular Docking and Pharmacophore Analysis of Compounds from Ginger (Zingiber officinale) as Inhibitor for Dengue DEN2 NS2B/NS3 Serine Protease
Authors: Frimayanti Neni , Mora Enda , Rindiyani Rindiyani 
Published: December 2023

<p>Dengue hemorrhagic fever (DHF) is a disease caused by the dengue virus (DENV). Dengue virus can enter the human body through the <em>Aedes aegypti</em> and <em>Aedes albopictus</em> mosquitoes. According to the Indonesian Ministry of Health, dengue hemorrhagic fever (DHF) is still a serious health problem in Indonesia. The type of dengue virus serotype most commonly found to cause infection in the human body is the DENV-2 serotype. This study aims to determine whether Ginger (<em>Zingiber officinale</em>) isolate compounds have potential as dengue DEN-2 NS2B/NS3 inhibitors. Samples used are compounds with IUPAC names (S)-5-hydroxy-1-(4-hydroxy-3-methoxyphenyl) octan-3-one (4-gingerol) and (S)-5-hydroxy-1-(3-methoxy-4-methylphenyl) decan-3-one. The method used is molecular docking and Pharmacophore using the MOE (Molecular Operating Environment) 2022.0901 software package. The results obtained based on the observed parameters of the two compounds isolated from ginger (<em>Zingiber officinale</em>) could be estimated as potential dengue DEN2 NS2B/NS3 inhibitors.</p><p> </p><p><img src="/public/site/images/fitria/rsz_75234-220064-1-ce_fix.jpg" alt="" /></p>
Mark-recapture validates the use of photo-identification for the widely distributed blue-spotted ribbontail ray, Taeniura lymma
Authors: McIvor Ashlie J. , Williams Collin T. , Rich Walter A. , Knochel Anna M. , Burns Neil M. , Berumen Michael L. 
Published: December 2023

Abstract

The ability to identify individual animals can provide valuable insights into the behaviour, life history, survivorship, and demographics of wild populations. Photo-identification (photo-ID) uses unique natural markings to identify individuals and can be effective for scalable and non-invasive research on marine fauna. The successful application of photo-ID requires that chosen distinguishing markings are unique to individuals and persist over time. In this study, we validate the use of dorsal spot patterns for identifying individual blue-spotted ribbontail rays (Taeniura lymma) in conjunction with traditional tagging methods. Spot patterns were unique among T. lymma with 90.3% of individuals correctly identified using I3S photo-matching software from images taken up to 496 days apart. In comparison, traditional physical tagging methods showed a tag loss rate of 27% and a maximum tag retention period of only 356 days. Our findings demonstrate the effectiveness of photo-ID as a tool to monitor populations and better understand the ecology of the blue-spotted ribbontail ray without the need for physical tagging. The validation of photo-ID for this widespread species is important as it enables behavioural and demographic changes to be easily tracked in relation to coastal threats such as human development and habitat degradation.
Influence of Hardness and Grain Size of the SS431 Material on the Slurry Erosion Wear through the Pot Tester at Higher Slurry Concentrations
Authors: BAGHEL YATISH KUMAR , PATEL VIVEK KUMAR 
Published: December 2023

Abstract

One of the most crucial considerations when developing any slurry transportation system is evaluating slurry erosion because it significantly contributes to the system's many component's ineffective operation and eventual failure. In the present work, the impact of the thermal-mechanical process (TMP) on the resistance of the slurry erosion wear of the target material has been investigated at a high slurry concentration (50% − 70% concentration by weight) and different rotational speeds (300–600 rpm) of the specimen. SS431 was used as the target material, and the Gleebles® 3800 simulator was used to perform the TMP on the target material. In the Gleebles® 3800 simulator, four strain rates (0.01, 0.1, 1, and 10 s− 1) were used for the deformation at two temperatures (950°C and 1050°C). A slurry pot tester was used to evaluate the slurry erosion wear for 15 hours at room temperature. TMP specimens have been shown to have more excellent resistance to slurry erosion as compared to the without-processed specimen (as-received material). The best resistance to slurry erosion was observed in specimens that had been TMP at 1050°C with a strain rate of 1 s− 1. Correlations had been found between various target material properties (hardness and grain size) as well as flow properties (solid concentration and rotational speed of the specimens) and the slurry erosion wear, all of which contribute to the erosion mechanism.
Valorization of Egg Shell Membrane as Protein Source in Soft Gel Capsules
Authors: Evrendilek Gulsun Akdemir , Demir İrem , Karakaya Nusret 
Published: December 2023

Abstract
Separation of egg shell membrane (ESM) from the shell by ETDA, acetic acid, HCl and water, its solubilization, and determination of important properties in addition to its usage in soft gel capsules were studied. SDS and T at 0.1, 0.5, and 1.0% concentrations up to 1440 min retention time revealed that 100 mM EDTA at 1:20 and 1:40 ratios ad water at 1:40 ratio gave the highest protein concentration after washing. Ovocleidin-17, ovocleidin-23, lysozyme, ovomucoid, ovalbumin, and avidin with 15 different amino acids were detected in ESM proteins. Soluble ESM proteins had moderate water holding (11.70±1.78-13.00±0.77 g/g) and oil holding capacities (10.60±2.09-11.52±1.18 g/g) with emulsion stability and emulsion activity indexes of 0.06±0.01-15.21±0.37% and 0.0000±0.000-0.0212±0.003 /g, respectively. Formulated soft gel capsules containing 1.03 mg/g-1.45 mg/g of ESM protein had the shelf life of 32 weeks at +4°C. Soluble ESM proteins can be utilized as protein supplements in soft gel form.
The value of learning to perform ascites puncture using procedural simulation in maintaining skills in the medium term: a quasi-experimental study
Authors: Hammami Aya , Ghali Hela , Elleuch Nour , Khalil Ben Saad Omar , Jaziri Hanen , Ksiaa Mehdi , Ali Habiba Sik 
Published: December 2023

Abstract
Introduction:
Medical simulation has become an essential teaching method for all health professionals. It not only allows to acquire technical and non-technical knowledge, but also help the maintenance of acquired knowledge in the medium and long term. Ascites puncture is part of the basic technical procedures learned by medical students during their internship.
Objectives
To evaluate the role of simulation-based learning of ascites puncture on the improvement of theoretical knowledge and maintenance of skills at 3 months.
Methods
We conducted a quasi-experimental study at the simulation center at the Faculty of Medicine of Sousse between November 2020 and June 2021. We included learners in their third year of medical studies who had a hospital internship in the gastroenterology department at Sahloul Hospital in Sousse. All learners attended the initial simulation session on ascites fluid puncture. Thereafter, they were free to accept or refuse participation in the evaluation session that was scheduled after 3 months, depending on their availability.
Results
Forty learners participated in the procedural simulation of the ascites fluid puncture technique. Thirty-four (85%) were female and six (5%) were male. In our study, we showed that following procedural simulation training of ascites puncture, there was a significant improvement in the theoretical knowledge of the learners (p < 0.000). Objective assessment of technical skills after 3 months showed the benefit on performance maintenance (p < 0.000).
Conclusion
Our study confirmed the benefit of simulation-based learning on the improvement of theoretical knowledge and the maintenance of technical performance in the medium term.
Minocycline abrogates individual differences in nerve injury-evoked affective disturbances in male rats and prevents associated supraspinal neuroinflammation
Authors: O’Brien Jayden A. , Austin Paul J. 
Published: December 2023

Abstract

Chronic neuropathic pain precipitates a complex range of affective and behavioural disturbances that differ markedly between individuals. While the reasons for differences in pain-related disability are not well understood, supraspinal neuroimmune interactions are implicated. Minocycline has antidepressant effects in humans and attenuates affective disturbances in rodent models of pain, and acts act by reducing neuroinflammation in both the spinal cord and brain. Previous studies, however, tend not to investigate how minocycline modulates individual affective responses to nerve injury, or rely on non-naturalistic behavioural paradigms that fail to capture the complexity of rodent behaviour. We investigated the development and resolution of pain-related affective disturbances in nerve-injured male rats by measuring multiple spontaneous ethological endpoints on a longitudinal naturalistic foraging paradigm, and the effect of chronic oral minocycline administration on these changes. Disrupted foraging behaviours appeared in 22% of nerve-injured rats – termed ‘affected’ rats – and were present at day 14 but partially resolved by day 21 post-injury. Minocycline completely prevented the emergence of an affected subgroup while only partly attenuating mechanical allodynia, dissociating the relationship between pain and affect. This was associated with a lasting downregulation of ΔFosB expression in ventral hippocampal neurons at day 21 post-injury. Markers of microglia-mediated neuroinflammation were not present by day 21, however proinflammatory microglial polarisation was apparent in the medial prefrontal cortex of affected rats and not in CCI minocycline rats. Individual differences in affective disturbances following nerve injury are therefore temporally related to altered microglial morphology and hippocampal neuronal activation, and are abrogated by minocycline.
Beyond group classification: probabilistic differential diagnosis of frontotemporal dementia and Alzheimer’s disease with MRI and CSF biomarkers.
Authors: Pérez-Millan Agnès , Thirion Bertrand , Falgàs Neus , Borrego-Écija Sergi , Bosch Beatriz , Juncà-Parella Jordi , Tort-Merino Adrià , Sarto Jordi , Augé Josep Maria , Antonell Anna , Bargalló Nuria , Balasa Mircea , Lladó Albert , Sánchez-Valle Raquel , Sala-Llonch Roser 
Published: December 2023

Abstract
Background
Neuroimaging and fluid biomarkers are used in clinics to differentiate frontotemporal dementia (FTD) from Alzheimer’s disease (AD) and other neurodegenerative and non-neurodegenerative disorders. We implemented a machine learning (ML) algorithm that provides individual probabilistic scores for these patients based on magnetic resonance imaging (MRI) and cerebrospinal fluid (CSF) data.
Methods
We used a calibrated classifier with a Support Vector Machine with MRI data. We obtained group classifications and individual probabilities associated with group correspondence. We used the individual probabilities to address the clinical problem of confidence in the diagnosis. We investigated whether combining MRI and CSF levels of Neurofilament light (NfL) and 14-3-3 could improve the diagnosis confidence.
Results
215 AD patients (65 ± 10 years, 137 women), 103 FTD patients (64 ± 8 years, 49 women), and 173 healthy controls (CTR) (59 ± 15 years, 106 women) were studied. With MRI data only, we obtained accuracies of 88% in the AD vs. healthy controls (CTR) classification, 87% for FTD vs. CTR, 82% for AD vs. FTD, and 80% when differentiating the three groups. A total of 74% of FTD and 73% of AD participants have a high (≥ 0.8) probability of accurate diagnosis in the FTD vs. AD comparison. Adding CSF-NfL and 14-3-3 levels slightly improved the accuracy and the number of patients in the high diagnosis confidence group.
Conclusion
We propose a ML algorithm that provides individual diagnostic probabilities, and we validate it using MRI and/or CSF data. Our solution holds promise towards clinical applications as support to clinical findings or in settings with limited access to expert diagnoses.