bluuebunny/crossref_metadata_2025_split huggingface dataset:
Genetic Expressions and Evaluation of Insecticidal activity of some Essential Oil and Methomyl Lannate 90% against Spodoptera frugiperda
Authors: Sadek Hanaa E , Elbehery Huda H , Mohamed shereen Abdel-Hameed , T.E Abd El-wahab 
Published: December 2023

Abstract

Background: Fall Armyworm (FAW)Spodoptera frugiperdais regarded as a major pest of various economic crops, their caterpillars are a highly destructive and have a wide host range. The application of traditional pesticides is the main strategies used for its control, that resulting to number of negative impacts of pesticides on the environment and development of pesticide resistance.MethodsThis study's goal was to assess the insecticide potency of three essential oils [ rosemary (Rosmarinus officinalisL.), lemongrass (Cymbopogon citratus) and Cinnamon (Cinnamomumzeylanicum)] and Methomyl Lannate 90% commerial Insecticide to controlS. frugiperda(fall armyworm) and their effected-on Expression of caspase-8 and Inhibitor of Apoptosis Protein (IAP) genes and Expression of Acetylcholinesterase (AChE) gene in Fall Armyworm (FAW).ResultsThe insecticidal activity against 2ndlarval instar of fall armyworm was evaluated with five concentrations (2.5%, 2%, 1.0%, 0.5% and 0.25%) for essential oil and four concentrations 0.4%, 0.2%,0.15% and 0.05% for Methomyl Lannate 90%. The findings indicated that raising both essential oil concentrations and Methomyl Lannate 90%, resulted in increased the larval mortality at high concentration. The expression levels of Ache gene in the treated by low dose (0.3 µ/L) of Methomyl Lannate were increased (by 313%) significant compared with the control but without significant differences.Conclusions, the tested essential oils showed insecticidal activity against the2ndlarval instar ofS. frugiperdadeath as a result of treatment with the tested oils having an effect on the genes that the pest uses to express critical processes (genes of apoptosis).
A comparative assessment of biomethane potential of fresh fecal matter and fecal sludge and its correlation with malodor
Authors: Choudhury Atun Roy , Singh Neha , Lalwani Jitesh , Rao Goriparthi Mallikarjuna , Prakash Konyala Bhanu , Chiradeep Nadella , Abhishek Nayakwadi , Palani Sankar Ganesh 
Published: December 2023

Abstract

Comprehensive and proper management of fecal sludge (FS) is an ongoing concern in many nations. Decentralized fecal sludge treatment plants (FSTPs) are effective in this regard; however, many have experienced strong public opposition, based partly on suspicion of malodor. Fecal sludge and freshly generated fecal matter (FM) samples from various FSTPs were collected, characterized, and investigated for biomethane potential. The homogenized samples were anaerobically digested for 28 days. Digestion successfully reduced total suspended solids, biochemical oxygen demand, and threshold odor number values of 97,350-97,420 mg/l, 43,230-43,260 mg/l, and 130-150 for FM, to 49,500-49,650 mg/l, 23,760-23,850 mg/l, and 33-38, respectively, for FS samples. The comprehensive gas yield from Bhongir, Boduppal, and Shadnagar FS samples was 40, 55, and 31 ml, respectively. In contrast, cumulative gas generation from the FM was 26,361 ml. Digestion of FS samples also reduced concentrations of volatile solids and coliforms by 66-72% and 99%, respectively. Characterization of gas samples revealed methane and carbon dioxide concentrations as 56% and 22% for FM, and 0.4% and 61% for FS samples, respectively. Hydrogen sulfide and ammonia gas were absent in FS samples, dispelling common societal misconceptions of FSTPs being associated with malodor.
A new data-driven model to predict monthly runoff at watershed scale: insights from deep learning method applied in data-driven model
Authors: Jia Shunqing , Wang Xihua , Liu Zejun , Mao Boyang 
Published: December 2023

Abstract

Accurate forecasting of mid to long-term runoff is essential for water resources management and planning. However, the traditional model can’t predict well and the precision of runoff forecast needs to be further improved. Here, we proposed a noval data-driven model called RLMD -SMA-GRU for mid to long-term runoff prediction in three hydrographic stations (Heishiguan, Baimasi and Longmenzhen) of Yiluo River Watershed (middle of China) using monthly runoff data from 2007 to 2022. The results showed that (1) the new data-driven model (RLMD -SMA-GRU) had the highest monthly runoff prediction accuracy. Both RLMD and SMA can improve the prediction accuracy of the model (NSE=0.9466). (2) The accuracy of Models in wet season outperformed in dry season. (3) The hydrological stations with large discharge and stable runoff sequence have better forecasting effect. The RLMD-SMA-GRU model has good applicability and can be applied to the monthly runoff forecast at watershed scale.
Explainable and generalizable AI-driven informatics for modeling an ultra-precision machining temperature conditioning system
Authors: Luo Chen , Li Aojin , Xiao Jiang , Li Ming , Zhou Lingchuan , Li Chuan , Li Yun 
Published: December 2023

Abstract
Certain ultra-precision machining requires high-precision control of its operating temperature, which requires high-fidelity modeling that reflects variations in the operating conditions. Machine learning based data-driven models and models derived from physical principles are currently inadequate in this regard. This paper develops a modeling method based on heterogenous informatics towards explainable and generalizable artificial intelligence (AI). The method integrates first principles of a white-box model with machine learning black boxes, resulting in a “gray-box model”. The physical principles play the role of an explainable global meta-structure of the overall system, while the black boxes play the role for generalizable local fitting. The gray-box model thus aggregates implicit variables and relationships between variables that cannot be captured otherwise in a white-box model due to ignored or unmeasurable nonlinearities, including nonlinear trends in the operating conditions. Experiments on an industrial clean-room high-precision temperature control system verify that the output of the gray-box model is closer to the actual system response compared with conventional models under varying operating conditions.
Spectroscopy-Guided Discovery of Three-Dimensional Structures of Disordered Materials with Diffusion Models
Authors: Pham Tuan Anh , Kwon Hyuna , Hsu Tim , Sun Wenyu , Jeong Wonseok , Aydin Fikret , Chapman James , Chen Xiao , Carbone Matthew , Lu Deyu , Zhou Fei 
Published: December 2023

Abstract

The ability to rapidly develop materials with desired properties has a transformative impact on a broad range of emerging technologies. In this work, we introduce a new framework based on the diffusion model, a recent generative machine learning method, to predict 3D structures of disordered materials from a target property. For demonstration, we apply the model to identify the atomic structures of amorphous carbons (a-C) as a representative material system from the target X-ray absorption near edge structure (XANES) spectra--a common experimental technique to probe atomic structures of materials. We show that conditional generation guided by XANES spectra reproduces key features of the target structures. Furthermore, we show that our model can steer the generative process to tailor atomic arrangements for a specific XANES spectrum. Finally, our generative model exhibits a remarkable scale-agnostic property, thereby enabling generation of realistic, large-scale structures through learning from a small-scale dataset (i.e., with small unit cells). Our work represents a significant stride in bridging the gap between materials characterization and atomic structure determination; in addition, it can be leveraged for materials discovery in exploring various material properties as targeted.
miR-451a was selectively sorted into exosomes and promoted the progression of esophageal squamous cell carcinoma through CAB39
Authors: Cheng Xiaolong , Wang Lu , Wu Qinglu , Liu Huijuan , Liu Yiqian , Yan Zhenpeng , Chen Guohui , Shang Yao , Xu Songrui , Zhou Qichao , Ting Yan 
Published: December 2023

Abstract
Exosomes are emerging mediators of cell-cell communication, which are secreted from cells and may be conveyed to recipient cells for cell biological processes. Here, we examined exosome miRNA expression in esophageal squamous cell carcinoma (ESCC) cells. We examine different miRNA expressions in cells and exosomes. To study the mechanisms of miRNA packaging into exosomes, we combined exosome proteomic data which is miR-451a interacts with YWHAE. Esophageal squamous tissues and matched tissues were compared from 155 patients, and CAB39 is related to TGF-β1. We found that miR-451a was encapsulated in the exosomes. Overexpression of YWHAE leads to miR-451a accumulation in the exosomes instead of donor cells. Furthermore, CAB39 was targeted with miR-451a. We found that CAB39 weakens antitumor immunity through TGF-β1 in ESCC. In summary, our data demonstrated that YWHAE selectively sorted miR-451a into exosomes and through the target of CAB39 weakened antitumor immunity promotes tumor progression.
Galcanezumab for the preventive treatment of episodic and chronic migraine in real life: A prospective multicenter study in Colombia and Mexico including effects on anxiety and depression - On behalf of ASOLACE
Authors: Munoz-Cerón Joe , Vélez-Jiménez Karina , Bohorquez-Valderrama Stephanía , Ildefonso Rodríguez-Leyva , Hernández-Beltrán Natalia , Gallo-Eugenio Loren , Moreno-Rodríguez Claudia , Jiménez-Jaramillo Juan , Guerra-Posada Carolina , Ramos-Romero Marta , Bernal-Cobo Rafael , Rojas-Villegas Yessica , Cavanzo-Henao Paula , Reydmar López-González 
Published: December 2023

Abstract

Introduction
Galcanezumab is an innovative therapeutic option for individuals with migraine. To date, there is no information regarding treatment results for Colombia and Mexico. The aim of this study was to determine the efficacy and tolerability of galcanezumab in real life in patients from Colombia and Mexico.
Materials and methods
This was a prospective, independent, multicenter, real-life study. Ninety-eight patients ≥18 years of age with a diagnosis of episodic and chronic migraine (ICHD3 criteria) were included. At baseline, 3 months and 6 months, comparative analyses of migraine days/month, the HIT-6, GAD-7, PHQ-9 scales, analgesic days/month, global self-perception and incidence of collateral effects were performed.
Results
Ninety-eight patients were included [mean age, 43.6 (SD 12.91); age range, 18-82 years; women, 85.7%]. At baseline, 72.4% and 27.6% of patients had chronic migraine and episodic migraine, respectively. In the episodic migraine group, there was a decrease in migraine days from baseline [6.7 (IQR 9-3.5)] to 3 months [2 (IQR 4-1)] and 6 months [2 (IQR 3.5-1)] of follow-up(p 0.01 baseline vs 6 months).
Patients with chronic migraine changed from [24.2 (IQR 30-20)] at baseline to [9 (IQR 4-19.25)] at month 3 and to [6 (IQR 15-4)] at the end of follow-up (p< 0.01). HIT-6, GAD-7 and PHQ-9 scores were significantly lower at months 3 and 6 than at baseline. De novo constipation occurred in 8% of participants.
Conclusion
This study offers evidence of the efficacy of galcanezumab in real life, including an impact on psychiatric variables.
Investigation on induction heating process to join carbon reinforced polyamide (CF-PA6) composite sheets in the presence of metallic interlayer AA 1060 and AISI 1020
Authors: Das Bipul 
Published: December 2023

Abstract
Carbon-fibre-reinforced polymers have been extensively utilized in aviation, automobile and other critical sectors owing to their high strength-to-weight ratio and excellent stiffness. In these industrial usage, the material has to undergo various processes and joining is one of such critical processes. However, the classical joining techniques such as the use of mechanical fasteners and adhesives often result in stress concentration, increased weight, and large processing times unique to each curing cycle. The current research work demonstrates the potential of induction heating for joining carbon-fibre-reinforced polyamide and the influence of the interlayer materials on the joining process. AISI 1020 and AA1060 were used as the interlayer materials for joining the composite material. Numerical investigation of the induction heating was carried out considering the influence of process parameters such as coil current and stand-off distance on magnetic flux density, temperature distribution in the interlayer material. The analysis revealed that stand off distance of 6 mm and coil current 150 A were chosen as optimal process parameters with AISI 1020 as interlayer whereas with AA1060 as interlayer, stand-off distance 2 mm and coil current 200 A were chosen to achieve uniform heating with short processing time.
Novel Standardized Indexes of brainstem auditory evoked po-tentials （BAEPs）for Predicting Hearing Preservation in Vestibular Schwannomas
Authors: Jiao Liwu , Liu Xuyang , Zhu Hongtao , Guo Chao , Wang Junwen , Shu Kai 
Published: December 2023

Abstract

Hearing preservation (HP) during vestibular schwannomas (VSs) surgery poses a significant challenge. Although brainstem auditory evoked potentials (BAEPs) on the affected side are commonly employed to monitor cochlear nerve function, their low signal-to-noise ratio (SNR) renders them susceptible to interferences, compromising their reliability. We retrospectively analyzed the data of patients who underwent tumor resection, while binaural brainstem auditory evoked potentials (BAEPs) were simultaneously recorded during surgery. To standardize BAEPs on the affected side, we incorporated the synchronous healthy side as a reference (interval between affected and healthy side ≤ 3 minutes). A total of 127 patients were enrolled. Comparison of the raw BAEPs data pre- and post- tumor resection revealed that neither V-wave amplitude (Am-V) nor latency (La-V) could serve as reliable predictors of HP simultaneously. However, following standardization, V-wave latency (STIAS-La-V) and amplitude (STIAS-Am-V) emerged as stable predictors of HP. Furthermore, the intraoperative difference in V-wave amplitude (D-Am-V) predicted postoperative HP in patients with preoperative HP and remained predictive after standardization. The utilization of intraoperative synchronous healthy side BAEPs as a reference to eliminate interferences proves to be an effective approach in enhancing the reliability of BAEPs for predicting HP in VSs patients.
“I couldn´t say goodbye”: Thematic analysis of interviews with bereaved relatives who lost their loved ones during the COVID-19 pandemic
Authors: Vlckova Karolina , Polakova Kristyna , Houska Adam , Zindulkova Marketa , Loucka Martin 
Published: December 2023

Abstract

Background
Delivering serious news is usually challenging for healthcare professionals and the pandemic of COVID-19 and related restrictions brought additional challenges in this process. This study aimed to explore the experience of bereaved relatives with receiving serious news from healthcare providers during the pandemic COVID-19.
Methods
This was a qualitative study using deductive thematic analysis of data collected in semi-structured interviews with bereaved relatives. Data were collected from July to August 2022 in person/via phone with bereaved relatives who lost their relatives during the pandemic (from March 2020 to March 2022). Participants were recruited using a convenience sample and snowball method through social media and through one university hospital palliative care unit that invited bereaved relatives of deceased patients treated at the unit to participate in this study.
Results
A total of 22 participants, consisting of 4 men and 18 women, were interviewed for this study. Most of the participants were sons or daughters of individuals who had passed away (5 grandchildren, 14 sons/daughters, 2 spouses, 1 great-niece). Six themes were identified: Tendency to express understanding for difficult conditions of care, Reduced contact with loved ones, Fear of COVID-19, Lack of empathetic communication with staff, Need for emotional support, Need for detailed and honest communication.
Conclusions
Overcoming the challenging circumstances of delivering serious news during a pandemic can be achieved by implementing frequent communication using various communication tools, maintaining empathy and honesty in the communication process, and providing detailed information to relatives despite visiting restrictions.
Hybrid simplicial-randomized approximate stochastic dynamic programming for multireservoir optimization
Authors: Zephyr Luckny , Lamond Bernard F. , Lang Pascal 
Published: December 2023

Abstract

We revisit an approximate stochastic dynamic programming method that we proposed earlier for the optimization of multireservoir problems. The method exploits the convexity properties of the value function to sample the reservoir level space based on the local curvature of the value function, which is estimated by the difference between a lower and an upper bounds (error bound). Unlike the previous approach where the state space was exhaustively partitioned into full dimensional simplices whose vertices formed a discrete grid over which the value function was approximated, here we propose instead a new randomized approach for selecting the grid points from a small number of randomly sampled simplices from which an error bound is estimated. Results of numerical experiments on three literature test problems and simulated midterm reservoir optimization problems illustrate the advantages of the randomized approach which can solve models of higher dimensions than with the exhausitive approach.
A Cross-Sectional Survey on Generation Z Physicians: Professional Value, Educational Expectations, and Work Environment Preferences
Authors: Satoh Kasumi , Mitani Yuki , Ishikane Masahiro , Kamada Shuhei 
Published: December 2023

Abstract
Generation Z (Gen Z) physicians, born between the mid-1990s and the mid-2010s, bring unique professional values and expectations to clinical practice shaped by technological and socioeconomic changes. This study explored these aspects of Gen Z physicians in Japan. A cross-sectional survey focusing on professional values, job-related training, supervisor attitudes, and work environments was conducted among first-year to third-year physicians in Japan. The participants were categorized into Gen Z (≤ 29 years) and non-Gen Z groups. Wilcoxon rank-sum tests identified significant differences between the groups. Of the 429 respondents, 391 were Gen Z members. They value job satisfaction, working for the benefit of others, embracing new challenges, and desire immediate feedback. Notable differences between Gen Z and non-Gen Z members include viewing work primarily as a means of personal life and preferences for teamwork, immediate feedback, proactive communication from supervisors, and chat-based workplace communication. Japanese Gen Z physicians prioritize internal motivation, economic stability, immediate feedback, digital technological integration, and collaborative work environments. These findings necessitate adapted approaches to medical education and workplace settings that align with the distinct outlook of this generation.
Welding of additive manufacturing AlSi10Mg alloys using a laser metal deposition process with different heat input
Authors: Li Jingchuan , Cui Li , Wu Defan , Wang Can , Shi Zhenfu , He Dingyong , Cao Qing 
Published: December 2023

Abstract

Welding of AlSi10Mg alloys fabricated by additive manufacturing (AM) has been recently conducted in response to the demands for joining or repairing the AM parts. However, high susceptibility to porosity occurred in the weld metal (WM) poses a significant challenge for fusion welding of AM AlSi10Mg alloys. The laser metal deposition (LMD) process has emerged as a promising welding solution due to its low dilution rate for reducing the porosity. In this study, LMD welding of AM AlSi10Mg alloys was carried out employing different heat input with five and eight tracks. The study systematically assessed the impact of heat input on porosity, microstructure, microhardness, and tensile properties of the welded joints. As a result, the decrease of heat input from 200 to 65 J/mm results in a substantial reduction in porosity from 7.0% to 2.1%. Additionally, this reduction leads to a 29.4% increase in ultimate tensile strength (UTS) and an 11.7% increase in elongation-to-failure (EI). Notably, the upper region of joints with eight tracks possessing low heat input displays lower porosity and superior mechanical properties than the bottom region with relatively high heat input. Furthermore, the WM with eight tracks exhibits a refinement of α-Al cells and Si-rich eutectic phases, improved connectivity of Si-rich networks, increased solid solution strengthening, compared to the five-track joints with higher heat input. In conclusion, low heat input of the upper region in the LMD welded joints has proven effective in minimizing hydrogen pores, enhancing WM microstructure, and improving the mechanical properties of welded joints.
Long noncoding RNA BANCR promotes lymphangiogenesis and lymph node metastasis of pancreatic carcinoma by regulating VEGF-C/VEGFR-3 signaling pathway
Authors: Hao Shaolong , Li Zeqian , Ji Yu , Sun Hao , Nie Fang , Hu Yang , Zhang Bo , Ji Kailun , Ding Yuchuan , Han Wei 
Published: December 2023

Abstract

Background Long noncoding RNAs ( lncRNAs) have proved to play important roles in the tumorigenesis and development of pancreatic carcinoma (PC). The aim of our study is to investigate the expression of long noncoding BRAF-activated noncoding RNA (BANCR) and its role in PC lymph node metastasis. Methods BANCR expression was detected in PC tissues by using Real-time quantitative PCR (RT-qPCR). The correlation between BANCR expression and lymph node metastasis was analyzed. Immunofluorescence staining was used to determine microlymphatic vessel density (MLVD) of peritumoral tissues. The correlation between MLVD and lymph node metastasis and the association between BANCR expression and MLVD were also analyzed. VEGF-C and VEGFR-3 expressions in PC cells were detected by western blotin vitro, and the regulatory role of BANCR on VEGF-C/VEGFR-3 was identified by cell transfection techniques. The transfected PC cells were co-cultured with human lymphatic endothelial cells (HLECs) and the MLVD was detected by the magnification inverted fluorescence microscope. Results BANCR expression was remarkably increased in PC tissues, especially in the lymph node metastasis group (P < 0.0001). MLVD of the PC tissues in the lymph node metastasis group was significantly higher than the group without lymph node metastasis (P < 0.0001). The BANCR expression level significantly correlated with MLVD (P < 0.05). The result was further verified in PC cell lines. Depletion of BANCR inhibits lymphangiogenesis and down regulates VEGF-C/VEGFR-3 (P < 0.05). However, Overexpression of VEGF-C could counteract the inhibitory effect of siBANCR on lymphangiogenesis. Conclusions BANCR promotes lymphangiogenesis and lymph node metastasis of PC by regulating the VEGF-C /VEGFR-3 signaling pathway.