bluuebunny/crossref_metadata_2025_split huggingface dataset:
Internet Infrastructure Construction and Digital Productive Forces: Empirical Evidence from China
Authors: Yang Zhiliang , Li Juan , Long Jinfeng , Zhao Jialing , Du Junhong 
Published: January 2025

Abstract

Internet infrastructure construction is an important condition to promote the development of digital productivity, and an important guarantee to promote the digital economy as a new driving force for economic growth. This paper analyzes the impact of internet infrastructure development on digital productivity using 2011–2019 prefecture-level city panel data and a quasi-natural experiment on the "Broadband China" pilot policy. The study concludes that internet infrastructure development significantly promotes the development of digital productivity, and the result passes several robustness tests. The promotion effect of internet infrastructure construction on digital productivity has significant heterogeneity among regions, between cities of different administrative levels, and between cities in urban agglomerations and non-urban agglomerations. Meanwhile, the mechanism analysis finds that internet infrastructure development affects digital productivity development through four ways: attracting the concentration of highly skilled personnel, improving the level of marketization, stimulating the city's innovation vitality, and growing the science and technology service industry.
Predictive value of lymphocyte-to-C-reactive protein ratio for predicting initial and repeated intravenous immunoglobulin resistance in a large cohort of Kawasaki disease: a prospective cohort study
Authors: Cui Yaru , Ye Pingting , Duan Hongyu , Liu Xiaoliang , Zhou Kaiyu , Hua Yimin , Ma Fan , Li Jinhui , Shao Shuran , wang Chuan 
Published: January 2025

Abstract

Lmphocyte to C-reactive protein ratio (LCR) has tremendous predictive power for diseases with similar pathogenesis to Kawasaki disease (KD). The evidence on the prognostic value of LCR for IVIG resistance, especially for repeated IVIG resistance in KD, was scarce. We conducted a prospective cohort study comprising 1607 individuals with Kawasaki disease to evaluate the predictive value of LCR for both the initial and repeated IVIG resistance in KD. A comparison was made between the initial/repeated IVIG-resistance group and the initial/repeated IVIG-response group. We found that LCR was markedly reduced in both initial and repeated IVIG non-responders and was recognized as an independent risk factor for forecasting both initial and repeated IVIG resistance in KD. The optimal cut-off values of LCR for predicting initial and repeated IVIG resistance were 0.042×10^9 and 0.025×10^9, respectively, with sensitivities of 74.1% and 51.3%, and specificities of 65.9% and 55.8%. LCR may be a complementary laboratory marker for predicting initial and repeated IVIG resistance to guide clinical management.
Effectiveness of Dry Needling for Chronic Low Back Pain: An Up-to-Date Meta-Analysis of Randomized Controlled Trials
Authors: Sario Alessandro Di 
Published: January 2025

Abstract

This meta-analysis evaluated the effectiveness of dry needling (DN) for chronic low back pain (CLBP) by synthesizing data from 13 randomized controlled trials (RCTs) involving 590 participants. Primary outcomes included pain intensity (Visual Analog Scale [VAS] or Numeric Pain Rating Scale [NPRS]), functional disability (Oswestry Disability Index [ODI] or Roland-Morris Disability Questionnaire [RMDQ]), and pressure pain threshold (PPT). Secondary outcomes assessed quality of life, flexibility, mobility, and psychological factors. A systematic search and random-effects model analysis found that DN significantly reduced pain intensity (SMD = -0.78; 95% CI: -1.05 to -0.52) and improved functional disability (SMD = -0.64; 95% CI: -0.91 to -0.37). Moderate PPT improvements were noted (SMD = 0.48; 95% CI: 0.21 to 0.75). Moderate to high heterogeneity (I² = 55%-70%) suggested variability in DN protocols and study designs. Subgroup analyses indicated DN combined with physical therapy yielded better functional outcomes than DN alone. While DN shows promise for short-term relief of CLBP, standardized protocols and long-term efficacy studies are needed. PERSPECTIVE This meta-analysis highlights dry needling's potential for reducing pain and improving function in CLBP management, supporting its integration into multimodal treatment strategies.
Complexity of Conflict for Islamic Educational Management Student; Humanistic Approach as a Solution
Authors: Defi Wahyu Fitrina , Gistituati Nurhizrah 
Published: January 2025

The realm of Islamic educational management is not immune to conflicts, which can arise from various sources such as differing ideologies, cultural disparities, or administrative challenges. This study delves into the multifaceted dimensions of conflicts faced by Islamic educational management students. By employing a humanistic approach, this research seeks to unravel the intricate layers of conflicts within the context of Islamic education and offers innovative solutions to mitigate their adverse effects. Drawing from theories rooted in humanism, the study explores the psychological and sociocultural aspects of conflict resolution, emphasizing empathy, understanding, and effective communication. Through in-depth qualitative analysis and case studies, the research provides valuable insights into the root causes of conflicts, enabling Islamic educational management students to cultivate a harmonious learning environment. This study not only contributes to the academic discourse but also equips future leaders in Islamic education with practical strategies to navigate conflicts, fostering a conducive atmosphere for holistic learning and personal growth.
MARVELD1 Promotes the Invasiveness in Pancreatic Adenocarcinoma
through the Activation of Epithelial-to-Mesenchymal Transition
Authors: Luo Xianwei , Gao Zhenming 
Published: January 2025

Background:
MARVEL domain-containing 1 (MARVELD1) has been implicated in
the progression of several cancers, but its role in pancreatic adenocarcinoma (PAAD) remains
poorly understood.

background:
Pancreatic adenocarcinoma (PAAD) is a highly malignant form of cancer that originates in the pancreas, with its exocrine cells producing digestive enzymes. MARVEL domain-containing 1 (MARVELD1) is a protein that plays a significant role in various cellular processes.

Methods:
RNA-seq data from the TCGA-PAAD and GTEx-Pancreas cohorts were analyzed to assess
MARVELD1 expression. Stable MARVELD1 knockdown and overexpression were conducted
in BxPC3 and PANC-1 cells. Cell viability, proliferation, migration, and invasion were evaluated
using functional assays, and western blotting was employed to examine EMT-associated protein
levels, including Vimentin, MMP2, MMP9, and E-cadherin. Differentially expressed genes
(DEGs) between MARVELD1-high and MARVELD1-low groups were identified, and pathway
enrichment analyses were performed.

Results::
We observed a significant increase of MARVELD1 in PAAD patient samples, with elevated
MARVELD1 levels correlating with poor clinical survival. Knockdown of MARVELD1 in
PAAD cells remarkably decreased cell proliferation and colony formation, while overexpression
of MARVELD1 enhanced these properties. Moreover, simulated cell invasion and migration assay
further suggested that MARVELD1 might contribute to PAAD cell aggressiveness. Mechanistically,
MARVELD1 promoted tumor cell migration and invasion through the activation of Vimentin,
MMP2, and MMP9 protein while suppressing E-cadherin. Bioinformatics analysis revealed
that MARVELD1-high samples were enriched in EMT-related pathways, including TGF-β
receptor signaling, actin cytoskeleton regulation, and cell adhesion.

Conclusion::
Taken together, our study highlights the roles of MARVELD1 in promoting tumor
cell proliferation and invasion, suggesting its potential application as a prognostic and diagnostic
biomarker for PAAD in the clinical context.

conclusion:
Taken together, our study highlights that MARVELD1 is a tumor-promoting gene and might be a prognostic factor and potential therapeutic target for PAAD in clinical.
Research Prospects for Necroptosis in Inflammatory Diseases: A
Bibliometric Analysis
Authors: Tan Ya ting , Wang Mei juan , Wang Shu chao 
Published: January 2025

Background:
Necroptosis is a modifiable form of cell death mainly dependent
on RIPK3 and MLKL. The association between necroptosis and inflammation has
been a key focus of research. An increasing number of studies have shown that necroptosis
plays an important role in inflammatory diseases, such as inflammatory bowel disease.

Methods:
Articles published up to 2023 were searched on the Web of Science.
VOSviewer, CiteSpace, Gephi, and Microsoft Office Excel were used for bibliometric
analysis and visualisation. In addition, journal impact factors and journal partitions were
obtained through the Web of Science.

Results:
A total of 3011 articles were included in this study. The number of publications
and citations in the field increased year by year. China had the highest number of publications.
Cell Death & Disease published the most papers in the field. P. Vandenabeele is
one of the most important scholars in this field. The most cited reference was “Molecular
Mechanisms of cell death: recommendations of the Nomenclature Committee on Cell
Death”.We found substantial evidence that acute kidney injury, sepsis, cancer, and other
diseases are closely related to necroptosis. In addition, we found that inhibitors of necroptosis
have great potential in the treatment of inflammatory diseases.

Conclusion:
This is the first bibliometric analysis of studies related to necroptosis in inflammatory
diseases. Our results provide an overview of basic and influential research,
providing a basis for the identification of valuable research directions. Furthermore, this
work offers general insight into the role of necroptosis in inflammatory human diseases.

conclusion:
This study is the first to make a bibliometric analysis of the studies related to necroptosis in inflammatory diseases. Our research results
can provide the new coming researchers with the basic and influential research results to choose suitable and valuable research directions. Furthermore,
it could provide guidelines for necroptosis in inflammatory human diseases.
Metabolic Tagging Technology of Exosomes- An Updated Review
Authors: Sen Aniruddha , Mohanraj Palani Selvam , Nagaram Srinivas , Samanta Anita , Ashique Sumel , Islam Anas , Srivastava Shriyansh , Singh Harpreet , Mishra Arun Kumar , Chopra Shivani , Chopra Hitesh 
Published: January 2025

Abstract:
Exosomes are small extracellular vesicles secreted by various cell types, playing a crucial role in intercellular
communication by carrying proteins, lipids, and nucleic acids, thus holding significant potential in
diagnostics and therapeutics. Accurate labeling of exosomes is vital for studying their biogenesis, trafficking,
and functional properties, enabling precise tracking and manipulation. This review examines current labeling
techniques, including metabolic glycan labeling, chemical tagging, membrane fluorescent dyes, bio-conjugation,
non-covalent labeling, and cell-engineering approaches. Each method is analyzed for its efficiency, specificity,
and practicality, with attention to potential artifacts and challenges. Advancements in these techniques
are essential for improving our understanding of exosome biology and developing exosome-based diagnostic
and therapeutic strategies, providing researchers with valuable insights into state-of-the-art techniques and
their applications in exosome research.
Cellulose and Cellulose Nanomaterials: Recent Research and Applications in Medical Field
Authors: Khanday Murtaza Ahmad , Shergujri Danish Ahmad , Noor Aisha , Fayaz Shahid , Raza Syed Naiem , Mir Reyaz Hassan , Khan Nisar Ahmad 
Published: January 2025

Abstract:
Cellulose, the most prevalent biopolymer in the world, is comprehensively reviewed.
Cellulose occurs in fibrillar patterns with alternating crystalline and amorphous regions. The
non-toxic and -friendly nature of cellulose has made it beneficial in many fields, such as pharmaceuticals,
biomedical, nanotechnology, etc. Numerous sources, including the plant cell wall
and wood, some types of bacteria, algae, and tunicates can provide cellulose. This polysaccharide
is composed of a straight chain of d-glucose units attached by β (1 → 4) that extend in number
from several hundred to thousands. This review details the recent progress in the synthesis of
cellulose nanofibers or nanofibrillated cellulose, cellulose nanocrystals, commonly referred to as
nanocellulose, and bacterial cellulose. The methodologies and procedures for evaluating the
morphology, purity, crystallinity, mechanical, rheological, and other characteristics of cellulose
micro/nanomaterials are covered in this review. The current study also discusses several ways to
functionalize CNFs, CNCs, and BC. Finally, a guide to the synthesis of cellulose nanocomposites
is provided, along with possible uses in the biomedical field, such as wound healing, bone
tissue engineering, and artificial blood vessel production. Additionally, applications related to
the pharmaceutical industry are also highlighted.
Mechanism of HJ11 Decoction in the Treatment of Atherosclerosis Based on Network Pharmacology and Experimental Validation
Authors: Lu Fei , Zou Jiaxi , Xu Weiming , Zhang Fangyuan , Nie Wenyi , Zhao Yue , Jiang Lijie , Liang Lizhe , Hu Jingqing 
Published: January 2025

Background:
HJ11 (HJ11 decoction), which is based on the traditional prescription
Si-Miao-Yong-An decoction, has exerted a remarkable effect on atherosclerosis (AS).
Nevertheless, the main components and underlying mechanisms of HJ11 for treating AS remain
unclear.

Aim of the Study:
This study was designed to elucidate the mechanism of HJ11 in the treatment
of AS through network pharmacology and in vivo experimental validation.

Methods:
Network pharmacology was employed to explore the primary bioactive components
and targets of HJ11. AS-related genes were obtained from the GeneCards and DisGeNET databases
and screened for intersections with HJ11. A herb-compound-target interaction network
was constructed by Cytoscape 3.9.1, and molecular docking analyses were constructed on key
targets. By using a mouse model, the mechanism of action of HJ11 was further confirmed.

Results:
A total of 231 active components of HJ11, 1681 AS-related genes, and 156 common targets
were identified. Through the establishment of numerous networks, it was discovered that the
main association of the mechanism of HJ11 in AS therapy pertained to anti-inflammation. Important
substances included quercetin, kaempferol, and luteolin, while TNF-α, AKT1, IL-6, and
VEGFA were the main targets. Molecular docking demonstrated that there were favorable binding
interactions between active drugs (quercetin, kaempferol, and luteolin) and targets (TNF-α,
AKT1, IL-6, and VEGFA). In the in vivo study, HJ11 reduced the expression of TNF-α, AKT1,
IL-6, and VEGFA at both the mRNA and protein levels, inhibited atherosclerotic lesions in AS
mouse models, and retarded the development of retroarterioid sclerosis.

Conclusions:
HJ11 can inhibit inflammation and the progression of AS, and the mechanism
might involve downregulating the expression of TNF-α, AKT1, IL-6, and VEGFA.
The Effects of 1,8-Cineole Treatment on Benign Prostatic Hyperplasia in Rats
Authors: Al-Trad Bahaa , Abu Haija Yazan , Aljabali Alaa A. , Alomari Ghada , Tahat Lena , Al-Ghadi Muath Q. 
Published: January 2025

Background:
Benign prostatic hyperplasia is a non-malignant growth of the prostate
gland; it’s the most common prostatic growth in aging men. 1,8-cineole is a natural compound
that is extracted from the essential oil of several aromatic plants including Eucalyptus spp. Recent
studies have demonstrated the anti-inflammatory, antioxidant, and anticancer activities of
1,8-cineole. This study aims to investigate the effects of 1,8-cineole treatment on the development
of BPH induced by testosterone in rats.

Method:
Thirty adult male rats were divided into three groups (n=10): a control group, an untreated
BPH group that received subcutaneous injections of testosterone (3 mg/kg), and a
BPH+cineole group that received 50 mg/kg of cineole intraperitoneally in addition to testosterone
for 21 days. Histological changes, serum testosterone, and dihydrotestosterone (DHT)
levels, prostatic tissue content of the inflammatory biomarkers interleukin 1 beta (IL-1β) and
tumor necrosis factor alpha (TNF-α), oxidative stress biomarkers superoxide dismutase (SOD)
and malondialdehyde (MDA), angiogenesis biomarker vascular endothelial growth factor
(VEGF-A), cellular proliferation biomarker proliferating cell nuclear antigen (PCNA), transforming
growth factor beta-1 (TGF-β1), and pro-apoptotic (Bax) and anti-apoptotic (Bcl-2)
genes were analyzed.

Results:
Cineole treatment led to a reduction in the prostate weight-to-body weight ratio, as well
as the restoration of histopathological changes caused by testosterone. Cineole treatment reduced
the serum levels of testosterone and DHT, and the prostatic tissue levels of IL-1β, TNF-α,
VEGF-A, PCNA, and TGF-β1 compared to those in the BPH group. Additionally, cineole treatment
enhanced the SOD activity and decreased the MDA levels in the prostate tissue. Finally,
the mRNA expression of the Bax was increased, while the expression of the Bcl-2 was decreased
by cineole.

Conclusion:
Our results highlight the effectiveness of cineole in preventing BPH development in
rats. This preventive effect was attributed to the regulation of inflammatory responses, oxidative
stress, cellular proliferation, and apoptosis.
Preventive and Therapeutic effects of Metformin in Cancer: A Meta-Analysis of RCT and Cohort Studies
Authors: Getu Mikiyas Amare , Zhang Xianbin , Wang Jia , Xu Kunpeng , Ying Ying , Ma Li , Gong Peng 
Published: January 2025

Background:
There is discrepancy of results among various individual and me-ta-analytical studies about the effect of metformin on cancer risk and patients’ survival. Therefore, we have conducted a comprehensive, updated meta-analysis to evaluate the preventive and therapeutic effects of metformin for cancer patients, as well as the inci-dence of adverse reactions, among metformin users.

Methods:
A total of 18 studies (10 cohort studies and 8 randomized controlled trials) in-volving 1,300,820 participants from Europe, North America, and Asia were included in this meta-analysis.

Results:
No significant association was found between metformin use and overall survival (Hazard ratio = 1.02; 95% CI, 0.80 – 1.30) and progressive-free
survival (Hazard ratio = 1.00; 95% CI, 0.76 – 1.31). In addition, the summary risk estimates for adverse reactions of metformin were not statistically
significant between intervention and control groups (Risk Ratio = 1.11; 95% CI, 0.94 – 1.31). However, metformin use was associated with a reduction in
cancer risk (Hazard ratio = 0.90, 95% CI, 0.86 – 0.94).

Conclusion:
Metformin does not significantly prolong the overall survival and progressive-free survival of cancer patients, but it may effectively reduce the
risk of cancer occurrence.
PAV-05 Naphthoquinone Potently Inhibit Zika Virus Replication in Infected Cells
Authors: Cesar Cirne-Santos Claudio , Gomes Gonzaga Daniel Tadeu , Oliveira de Resende Gabriel , Gonçalves Mariana de Castro , Andrade Aymee da Silva , Furtado Pacheco Paulo Anastácio , dos Santos-Rodrigues Alexandre , Rabelo Vitor Won-Held , Abreu Paula Alvarez , Faria Robson Xavier , da Rocha David Rodrigues , da Silva Fernando de Carvalho , Ferreira Vitor Francisco , de Souza Barros Caroline , Nunes de Palmer Paixão Izabel Christina 
Published: January 2025

Background:
Zika (ZIKV) is a virus transmitted by mosquitoes that can cause Guillain-
Barré syndrome and congenital malformations like microcephaly. Given its explosive resurgence
and the resulting epidemics in 2016, the search for effective antiviral drugs has become absolutely
necessary.

Methods:
In this study, we examined the potential of naphthoquinone derivatives that have a sulfonamide
or sulfonate group to inhibit ZIKV replication in primary cultured neurons and in Vero cells.

Results:
In our in vitro studies, we found that PAV05 had low cytotoxicity with a CC50 of 329
μM ±3.6 for Vero cells and 290 μM ±3.5 for neurons. Additionally, we observed a strong inhibitory
activity on viral replication with an EC50 value of EC50 of 0.92 μM ±0.15 in Vero cells, resulting
in a Selectivity Index (SI) of 357. Even when added 16 hours post-infection, PAV05 maintained
its inhibitory effect. When PAV05 was evaluated in sub-optimal concentrations together
with Ribavirin, we observed a strong synergistic effect, with an inhibition greater than 90% even at
doses of 0.5 μM. In silico tests suggested that PAV05 may have effects on ZIKV NS2B-NS3.

Conclusion:
The ZIKV inhibitor described in this study shows promise as a compound for the
development of therapies against ZIKV. It may also be considered for inclusion in the portfolio of
broad-spectrum antiflavivirus inhibitors.

conclusion:
The ZIKV inhibitor described in this study shows promise as a potential compound for the development of anti-ZIKV therapies. It may also be considered for inclusion in the portfolio of broad-spectrum antiflavivirus drugs.
The Efficacy of Oxysophocarpine in Treating Cerebral Ischemia: Integration of Network Pharmacology and Experimental Validation
Authors: Wang Zhi , Qiao Haiqi , Yu Yang , Liu Siyun , Zhao Fang , Zhou Ru 
Published: January 2025

Objective:
The underlying mechanisms of Oxysophocarpine (OSC) in Cerebral Ischemia
(CI) treatment were investigated through network pharmacology, molecular docking, and in vitro
experiments.

background:
CI is a neurological disorder precipitated by a blood clot, which obstructs cerebral blood flow, resulting in inadequate oxygen and nutrient supply to the brain tissue. Prolonged cerebral ischemia can lead to persistent or progressive neurological and cognitive deficits. The primary treatment involves promptly restoring blood flow to the ischemic brain tissue post-ischemia. Despite this, effective therapeutic drugs remain lacking.

Methods:
The potential targets of OSC were predicted using the PubChem, SwissTargetPrediction,
and PharmMapper databases. Relevant CI targets were identified through the GeneCards and Online
Mendelian Inheritance in Man (OMIM) databases, and common targets between OSC and cerebral
ischemia were determined using Venny2.1.0. Drug-disease Protein-Protein Interaction (PPI) networks
were analyzed using the String database. Gene Ontology (GO) and Kyoto Encyclopedia of
Genes and Genomes (KEGG) enrichment analyses of key targets were conducted using the DAVID
database. Molecular docking verification was performed using Autodock Vina. The results of the
network pharmacological analysis were validated through in vitro experiments.

Results:
Mapping the drug and disease targets yielded 126 common targets. GO and KEGG enrichment
analysis revealed that OSC's therapeutic mechanism in CI involves multiple pathways, including
those related to cancer, MAPK signaling, and PI3K-Akt signaling. Molecular docking results
demonstrated strong binding activity of OSC to core protein targets. In vitro experiments indicated
that OSC enhances the survival rate of four hours of sugar deprivation and 12 hours of reoxygenation
(OGD4h/R12h) in bEnd.3 cells and reduces the protein expression of p-PI3K and p-Akt.

Conclusion:
The "multi-target and multi-mechanism" actions of OSC in CI treatment were elucidated
through network pharmacology and molecular docking, providing a scientific basis for further
investigation.