bluuebunny/crossref_metadata_2025_split huggingface dataset:
Development of Resistance to Type II JAK2 Inhibitors in MPN Depends on AXL Kinase and Is Targetable
Authors: Codilupi Tamara , Szybinski Jakub , Arunasalam Stefanie , Jungius Sarah , Dunbar Andrew C. , Stivala Simona , Brkic Sime , Albrecht Camille , Vokalova Lenka , Yang Julie L. , Buczak Katarzyna , Ghosh Nilabh , Passweg Jakob R. , Rovo Alicia , Angelillo-Scherrer Anne , Pankov Dmitry , Dirnhofer Stefan , Levine Ross L. , Koche Richard , Meyer Sara C. 
Published: November 2023

Abstract

Purpose:
Myeloproliferative neoplasms (MPN) dysregulate JAK2 signaling. Because clinical JAK2 inhibitors have limited disease-modifying effects, type II JAK2 inhibitors such as CHZ868 stabilizing inactive JAK2 and reducing MPN clones, gain interest. We studied whether MPN cells escape from type ll inhibition.

Experimental Design:
MPN cells were continuously exposed to CHZ868. We used phosphoproteomic analyses and ATAC/RNA sequencing to characterize acquired resistance to type II JAK2 inhibition, and targeted candidate mediators in MPN cells and mice.

Results:
MPN cells showed increased IC50 and reduced apoptosis upon CHZ868 reflecting acquired resistance to JAK2 inhibition. Among &gt;2,500 differential phospho-sites, MAPK pathway activation was most prominent, while JAK2-STAT3/5 remained suppressed. Altered histone occupancy promoting AP-1/GATA binding motif exposure associated with upregulated AXL kinase and enriched RAS target gene profiles. AXL knockdown resensitized MPN cells and combined JAK2/AXL inhibition using bemcentinib or gilteritinib reduced IC50 to levels of sensitive cells. While resistant cells induced tumor growth in NOD/SCID gamma mice despite JAK2 inhibition, JAK2/AXL inhibition largely prevented tumor progression. Because inhibitors of MAPK pathway kinases such as MEK are clinically used in other malignancies, we evaluated JAK2/MAPK inhibition with trametinib to interfere with AXL/MAPK-induced resistance. Tumor growth was halted similarly to JAK2/AXL inhibition and in a systemic cell line–derived mouse model, marrow infiltration was decreased supporting dependency on AXL/MAPK.

Conclusions:
We report on a novel mechanism of AXL/MAPK-driven escape from type II JAK2 inhibition, which is targetable at different nodes. This highlights AXL as mediator of acquired resistance warranting inhibition to enhance sustainability of JAK2 inhibition in MPN.
Platinum-Based Chemotherapy Attenuates the Effector Response of CD8 T Cells to Concomitant PD-1 Blockade
Authors: Mariniello Annapaola , Nasti Tahseen H. , Chang Daniel Y. , Hashimoto Masao , Malik Sakshi , McManus Daniel T. , Lee Judong , McGuire Donald J. , Cardenas Maria A. , Umana Pablo , Nicolini Valeria , Antia Rustom , Saha Ananya , Buchwald Zachary , Kissick Hayden , Ghorani Ehsan , Novello Silvia , Sangiolo Dario , Scagliotti Giorgio V. , Ramalingam Suresh S. , Ahmed Rafi 
Published: November 2023

Abstract

Purpose:
Combination of chemotherapy with programmed cell death 1 (PD-1) blockade is a front-line treatment for lung cancer. However, it remains unknown whether and how chemotherapy affects the response of exhausted CD8 T cells to PD-1 blockade.

Experimental Design:
We used the well-established mouse model of T-cell exhaustion with chronic lymphocytic choriomeningitis virus (LCMV) infection to assess the effect of chemotherapy (cisplatin+pemetrexed) on T-cell response to PD-1 blockade, in the absence of the impact of chemotherapy on antigen release and presentation observed in tumor models.

Results:
When concomitantly administered with PD-1 blockade, chemotherapy affected the differentiation path of LCMV-specific CD8 T cells from stem-like to transitory effector cells, thereby reducing their expansion and production of IFNγ. After combination treatment, these restrained effector responses resulted in impaired viral control, compared with PD-1 blockade alone. The sequential combination strategy, where PD-1 blockade followed chemotherapy, proved to be superior to the concomitant combination, preserving the proliferative response of exhausted CD8 T cells to PD-1 blockade. Our findings suggest that the stem-like CD8 T cells themselves are relatively unaffected by chemotherapy partly because they are quiescent and maintained by slow self-renewal at the steady state. However, upon the proliferative burst mediated by PD-1 blockade, the accelerated differentiation and self-renewal of stem-like cells may be curbed by concomitant chemotherapy, ultimately resulting in impaired overall CD8 T-cell effector functions.

Conclusions:
In a translational context, we provide a proof-of-concept to consider optimizing the timing of chemo-immunotherapy strategies for improved CD8 T-cell functions.
See related commentary by Vignali and Luke, p. 1705
Padrões de distribuição de elementos terras-raras nas suítes plutônicas Ediacaranas a Cambrianas no extremo nordeste da Província Borborema, Brasil
Authors: Pinheiro Dalton da Silva , Lucas Dinarte , Nascimento Marcos Antonio Leite do , Vilalva Frederico Castro Jobim 
Published: November 2023

O magmatismo Ediacarano a Cambriano no extremo NE da Província Borborema é representado por seis suítes plutônicas definidas com base em critérios químicos, petrográficos e texturais, sendo estas as suítes Shoshonítica, Calcioalcalina de alto K Porfirítica, Calcioalcalina de alto K Equigranular, Calcioalcalina, Alcalina e Alcalina Charnockítica. Este trabalho apresenta e discute os padrões de variação de elementos terras-raras (ETR) para essas suítes, utilizando a abordagem do método de lambda (λ) para obtenção dos coeficientes de forma (i.e. λ0, λ1, λ2, λ3) para os padrões de ETR. Os valores médios obtidos para tais coeficientes (notação λ0/λ1/λ2/λ3) são: suítes Shoshonítica (5,36/8,68/108,65/-1.438,32), Calcioalcalina de alto K Porfirítica (5,34/11,83/141,35/-1.464,81), Calcioalcalina de alto K Equigranular (5,43/9,29/152,15/-1.486,88), Calcioalcalina (4,77/5,44/149,65/-1.383,71), Alcalina (3,85/3,49/174,37/-1.282,47), AlcalinaFlores (5,63/4,12/152,31/-1.166,31) e Alcalina Charnockítica (5,60/9,98/128,10/-1.638,25). Os resultados apontam para forte influência no fracionamento de feldspatos nos padrões ETR observados, principalmente no que diz respeito às anomalias de Eu observadas utilizando λ0 como um marcador de fracionamento. Outros minerais como granada, clino e ortopiroxênio podem apresentar localmente influência sobre os baixos valores de λ1 e altos valores de λ3, enquanto os minerais que particionam álcalis influenciam valores altos de λ2.
The sense of ksénos in Ancient Greek
Authors: Ioannou Georgios 
Published: November 2023

Abstract
The present work looks at the term ksénos as an access point to the enacted model of hospitality—ksenía—in ancient Greece. It deduces the onomasiological and semasiological spread of the term across the model’s participants, namely GUEST, STRANGER but also HOST, into a schematic prototypical core within a complex and dynamic conceptual integration model. Along the spatial continuum of DISTANCE-APPROACHING-PROXIMITY, the analysis looks into APPROACHING as an emergent space, where GIFT-EXCHANGE is interpreted as a process of mental-space shift on the part of a stable SELF confronting the incoming OTHER. POSSESSIONS EXCHANGE conceptualised as non-commodifiable and non-alienable to the giver activates the metaphorical relation HAVE as BE. Thus, the abrupt confrontation is accommodated as an ad hoc partial substitutability of each participant’s identity by the identity of the other. Some Proto-Indo-European etymologies proposed in literature for the term are reviewed, and their compatibility with the present analysis is evaluated.
Synthetic-analytic variation in the formation of Greek comparatives and relative superlatives
Authors: Karkaletsou Foteini , Alexiadou Artemis 
Published: November 2023

Abstract
Many adjectives in Modern Greek form both synthetic and analytic comparatives and relative superlatives. To our knowledge, this is the first work to examine the triggers of the Synthetic-Analytic (S-A) variation in this language by means of a corpus study. To date, numerous studies have shown that a series of predictors (phonological, lexical, syntactic) appear to influence the S-A variation in English. The present paper focuses on some factors mentioned in the existing literature (e.g., frequency, number of syllables, syntactic position etc.) alongside Text Type, which is explicitly used as a predictor for the first time. Overall, our results suggest that 1) the S-A variation seems to be influenced by similar predictors cross-linguistically and 2) comparatives and relative superlatives show a partially different picture in Modern Greek, as is also the case in English (Cheung & Zhang 2016).
Work-related Alcohol Use
Authors: Halkjelsvik Torleif , Moan Inger Synnøve 
Published: November 2023

Abstract
Drinking alcohol with co-workers is a common practice in many countries. However, because consumption of alcohol is socially unaccepted in several religious groups, the use of alcohol in an occupational context may be discriminatory and have negative side-effects. In annual surveys of part- and fulltime employees in Norway conducted between 2015 and 2022, we found that employees affiliated with religious minorities more often experienced social exclusion due to work-related alcohol use than non-religious employees and the religious majority. Experiencing alcohol-related social exclusion was related to more negative perceptions of the social work environment and more absence from work. Restrictive alcohol practices and policies at the workplace were associated with less social exclusion and appeared to be protective for religious minorities, without impairing the social work environment of other employees. Social exclusion of religious minorities can be reduced if employers limit or avoid serving alcohol to employees.
Lacticaseibacillus rhamnosus and breastmilk are associated with a decreased risk of atopic dermatitis in very low birth weight premature infants
Authors: Uberos J. , Garcia-Cuesta A. , Carrasco-Solis M. , Ruiz-López A. , Fernandez-Marı́n E. , Campos-Martinez A. 
Published: November 2023

Abstract
In this study, we analyse the influence of nutrition during the early neonatal period on the development and prevention of atopic dermatitis (AD) in children with a history of very low birth weight (VLBW). A retrospective cohort study was performed of VLBW preterm infants to assess the risk of their developing AD during childhood, according to nutrition with breastmilk and/or probiotic supplementation during the neonatal period. The analysis focused on nutritional and early childhood follow-up data for 437 newborns, of whom 184 received probiotics up to 36 weeks postmenstrual age. AD was present in 23.5% of the study sample. Of the children who did not develop AD, 44.9% had received probiotics from birth to 36 weeks of gestational age. Therefore, the administration of probiotics to infants at less than 36 weeks postmenstrual age is associated with a protective effect against the development of AD (odds ratio (OR) 0.57; 95% confidence interval (CI) 0.34-0.93). Moreover, a protective interaction was observed between probiotic administration and breastmilk (OR 0.46; 95% CI 0.25-0.82). The adjusted data in the regression model allow us to observe a statistically significant association with the protective effect of Lacticaseibacillus rhamnosus with the development of AD at school age (OR 0.55; 95% CI 0.30-0.99). Probiotic supplementation in VLBW newborns is associated with a decreased risk of subsequent development of AD. Breastmilk strengthens the protective effect of probiotics against the development of AD.
Beauty of construction, richness of expression
Authors: Hyman Larry M. , Leben William R. 
Published: November 2023

Abstract
A History of the Hausa Language is the first book-length historical study of any language of the Chadic branch of Afro-Asiatic. It synthesizes and updates the scholarly output on the topic by Paul Newman, for many decades Hausa’s most productive and influential scholar. In this review article we discuss Newman’s most striking findings on the history of Hausa’s phonology, morphology, syntax, and lexicon, adding questions and critiques where called for. We find the book to be a contribution without parallel to Hausa and to African linguistics.
“I Was the Only Goyim There”: Linguistic Imitation and Socialization among Sephardic New Mexicans
Authors: Leiter Sarah 
Published: November 2023

Abstract
This article explores linguistic imitation as a strategy of socialization. It focuses on the ethnographic context of New Mexico’s Jewish community, which some Hispanic New Mexicans are beginning to join after discovering their Sephardic, or Iberian Jewish, ancestry. Although several are choosing to formally ‘return,’ or convert, to Judaism, they often feel unwelcome in the community and, therefore, do not always have interlocutors who might help to linguistically integrate them. In this context, they adopt various strategies for learning community language norms, including imitating the speech of veteran community members and reproducing Jewish English as learned from books and internet resources, even if doing so results in non-normative usages. They may also use elements of Yiddish to mirror language used within the local Jewish community, positioning themselves as Sephardic through the use of an Ashkenazi language.
Diasporic Papers
Authors: Sommer Tim 
Published: November 2023

Abstract
This article explores the impact of the Nobel Prize in Literature on the acquisition policies of literary archives. Focusing on laureates and the twenty-first-century fate of their manuscripts, it argues that the international reach of the prize is mirrored by a contemporary archival landscape that is at once global and unequal. Although many archives concentrate on collecting material from the linguistic and cultural context of which they themselves form part, the past two decades have also seen the emergence of a competitive international market for the papers of authors whose writings are marked – through high-profile distinctions such as the Nobel Prize – as belonging to the world literary canon. Illustrating its larger argument with the help of three case studies (Harold Pinter, J.M. Coetzee, Gabriel García Márquez), the article suggests that archivization consecrates laureates’ papers as global heritage at the same time that it reinforces the logic of literary nativism.
A World Prize for a World Thinker?
Authors: Spoerhase Carlos 
Published: November 2023

Abstract
To reconstruct the history of the Nobel Prize and its impact on the making of world literature is a task of staggering dimensions. Nevertheless, letters and archival documents offer a glimpse into its workings. This paper examines Hannah Arendt’s efforts to secure the Nobel Prize for Karl Jaspers, as a case study in the globalization of the literary field after the Second World War. It is shown how Arendt and her allies in the German and American publishing trade mobilized an international network of supporters in Sweden, Norway, Switzerland, France, Italy, Great Britain, Japan, and the United States in order to secure the “world prize” for the German “world thinker”. The paper also tries to explain why these intensive international efforts ultimately failed.
A new species of genus Tephritis Latreille and a new distribution record of genus Urophora Robineau-Desvoidy, from India
Authors: SINGH MANEESH PAL , DAROCH RAKESH , KORNEYEV SEVERYN V. , SHARMA ISHA 
Published: November 2023

A new species of Tephritis Latreille, Tephritis himalayae Maneesh and Korneyev, sp. n. is described from the higher hills of Himachal Pradesh (India). The species was found breeding on the very common orchard weed Cirsium falconeri (Hook.f.). The new species belongs to the hyoscyami-conura group of species and is very closely related to T. cardualis Hardy. An identification key for the genus Tephritis known from the Indian subcontinent is given. In addition, Urophora terebrans (Loew), a Palearctic species, is recorded from the mid-hills of Himachal Pradesh, India. Illustrations for both species are given.
Analyzing “Gray Zone” Turbulent Kinetic Energy Predictions in the Boundary Layer from Three WRF PBL Schemes over New York City and Comparison with Aircraft Measurements
Authors: Hope Austin P. , Lopez-Coto Israel , Hajny Kris , Tomlin Jay M. , Kaeser Robert , Stirm Brian , Karion Anna , Shepson Paul B. 
Published: November 2023

Abstract
We investigated the ability of three planetary boundary layer (PBL) schemes in the Weather Research and Forecasting (WRF) Model to simulate boundary layer turbulence in the “gray zone” (i.e., resolutions from 100 m to 1 km). The three schemes chosen are the well-established MYNN PBL scheme and the two newest PBL schemes added to WRF: the three-dimensional scale-adaptive turbulent kinetic energy scheme (SMS-3DTKE) and the E–ε parameterization scheme (EEPS). The SMS-3DTKE scheme is designed to be scale aware and avoid the double counting of TKE in simulations within the gray zone. We evaluated their performance using aircraft measurements obtained during three research flights immediately downwind of Manhattan, New York City, New York. The MYNN PBL scheme simulates TKE best, despite not being scale aware and slightly underestimating TKE from observations, whereas the SMS-3DTKE scheme appears to be overly scale aware for the three flights examined, in particular, when combined with the MM5 surface layer scheme. The EEPS scheme significantly underestimates TKE, mostly in the elevated layers of the boundary layer. In addition, we examined the impact of flow over tall buildings on observed TKE and found that only the windiest day showed a significant increase in TKE directly downwind of Manhattan. This impact was not reproduced by any of the model configurations, regardless of the land-use data selected, although the better resolved National Land Cover Database (NLCD) land use led to a slight improvement of the spatial distribution of TKE, implying that more explicit representation of the impact of tall buildings may be needed to fully capture their impact on boundary layer turbulence.

Significance Statement
Because the majority of the world’s population lives in cities, it is important to accurately simulate the atmosphere above and around these cities including the turbulence caused by tall buildings. This turbulence can significantly impact the mixing and dilution of air pollutants and other toxins in highly populated urban environments. The scale of cities often falls into what is known as the “gray zone” for turbulence modeling, which has been analyzed theoretically before but rarely in varied real-world conditions. Our analysis around New York City, New York, suggests that model turbulence schemes can match observations relatively well even at gray zone scales, although newer schemes require refinement, and all schemes tend to underestimate turbulence downwind of tall buildings.
Using Ensembles to Analyze Predictability Links in the Tropical Cyclone Flood Forecast Chain
Authors: Titley H. A. , Cloke H. L. , Stephens E. M. , Pappenberger F. , Zsoter E. 
Published: November 2023

Abstract
Fluvial flooding is a major cause of death and damages from tropical cyclones (TCs), so it is important to understand the predictability of river flooding in TC cases, and the potential of global ensemble flood forecast systems to inform warning and preparedness activities. This paper demonstrates a methodology using ensemble forecasts to follow predictability and uncertainty through the forecast chain in the Global Flood Awareness System (GloFAS) to explore the connections between the skill of the TC track, intensity, precipitation, and river discharge forecasts. Using the case of Hurricane Iota, which brought severe flooding to Central America in November 2020, we assess the performance of each ensemble member at each stage of the forecast, along with the overall spread and change between forecast runs, and analyze the connections between each forecast component. Strong relationships are found between track, precipitation, and river discharge skill. Changes in TC intensity skill only result in significant improvements in discharge skill in river catchments close to the landfall location that are impacted by the heavy rains around the eyewall. The rainfall from the wider storm circulation is crucial to flood impacts in most of the affected river basins, with a stronger relationship with the post-landfall track error rather than the precise landfall location. We recommend the wider application of this technique in TC cases to investigate how this cascade of predictability varies with different forecast and geographical contexts in order to help inform flood early warning in TCs.

Significance Statement
This study demonstrates a methodology to analyze the cascade of predictability and uncertainty through the various stages of the tropical cyclone (TC) flood forecasting chain, illustrating how it can provide useful information to modelers interested in optimizing flood forecast skill, and to those who prepare and communicate flood forecasts with stakeholders and end-users in TC cases. The results highlight the importance of improving verification of ensemble TC precipitation forecasts, and of focusing on more than just the category of the storm and landfall location when forecasting and communicating flood impacts in TC cases.
Model Development and Simulation for Predicting Proportional Changes in Traffic Volume as a Consequence of Natural Weather Hazards
Authors: Roh Hyuk-Jae 
Published: November 2023

Abstract
This study used a model to calculate the proportional drop for every vehicle class based on 266 climate patterns consisting of seven temperature groups and varied snowfalls. The winter traffic models use weigh-in-motion (WIM) traffic collected on the commuter roadway for 5 years. The marginal impact and combined effect of meteorological conditions on the proportional decrease in winter traffic volume are evaluated. The predicted percentage decrease in traffic for all three vehicle classes increases as temperature decreases and snowfall increases. Mathematical functions are fitted for the decreased patterns for the considered vehicle type. Roadway authorities may utilize traffic percentage decrease to identify weather-related traffic changes when planning winter highway operation and maintenance.