bluuebunny/crossref_metadata_2025_split huggingface dataset:
Bioactive compounds in coffee and their role in lowering the risk of major public health consequences: A review
Authors: Makiso Markos Urugo , Tola Yetenayet Bekele , Ogah Onwuchekwa , Endale Fitsum Liben 
Published: November 2023

AbstractThis article addresses the bioactive components in coffee aroma, their metabolism, and the mechanism of action in lowering the risk of various potential health problems. The main bioactive components involved in the perceived aroma of coffee and its related health benefits are caffeine, chlorogenic acid (CGA), trigonelline, diterpenes, and melanoids. These compounds are involved in various physiological activities. Caffeine has been shown to have anticancer properties, as well as the ability to prevent the onset and progression of hepatocellular carcinoma and to be anti‐inflammatory. CGA exhibits antioxidant action and is implicated in gut health, neurodegenerative disease protection, type 2 diabetes, and cardiovascular disease prevention. Furthermore, together with diterpenes, CGA has been linked to anticancer activity. Trigonelline, on the other side, has been found to lower oxidative stress by increasing antioxidant enzyme activity and scavenging reactive oxygen species. It also prevents the formation of kidney stones. Diterpenes and melanoids possess anti‐inflammatory and antioxidant properties, respectively. Consuming three to four cups of filtered coffee per day, depending on an individual's physiological condition and health status, has been linked to a lower risk of several degenerative diseases. Despite their health benefits, excessive coffee intake above the recommended daily dosage, calcium and vitamin D deficiency, and unfiltered coffee consumption all increase the risk of potential health concerns. In conclusion, moderate coffee consumption lowers the risk of different noncommunicable diseases.
Magnetic properties as indicators of pedogenic and pyrogenic processes at the Upper Paleolithic site of Kostenki 14
Authors: Kurgaeva Anastasiia , Sedov Sergey , Moreno‐Roso Sol , Barceinas Cruz Hermenegildo , Ortega Guerrero Beatriz , Solleiro‐Rebolledo Elizabeth , Sinitsyn Andrei 
Published: November 2023

AbstractIn geoarchaeological studies, there is an issue with distinguishing between natural and anthropogenic signals in pedological paleoarchives. With the pedostratigraphy of the Upper Paleolithic site of Kostenki 14, this issue is reflected by problems with the determination of features of pedogenic and pyrogenic processes. This issue was addressed by means of a thorough analysis of the magnetic properties of paleosols accompanied by micromorphological observations. Most of the humic samples were shown to be a result of pedogenesis, but two samples (a Paleolithic hearth sample and a sample from paleosol IIc) had features of intensely burnt material. The difference in the typical intensity of large‐scale (natural or human‐induced) and local‐scale anthropogenic fire allowed for suggesting that the magnetic properties of the burnt sample were the result of an anthropogenically controlled fire event, that is, a hearth. This study shows that the magnetic properties of paleosols can be used to differentiate anthropogenic activity, in particular—burning, from pedogenic processes. This indicator is especially helpful in finding disturbed combustion features when the hearth structure is lost. This methodology used to demonstrate the local human‐induced pyrogenic effect at the Upper Paleolithic site can contribute to the discussion of the niche construction effect of human activities in the Pleistocene.
Structural, static, and dynamic functional MRI predictors for conversion from mild cognitive impairment to Alzheimer's disease: Inter‐cohort validation of Shanghai Memory Study and ADNI
Authors: Chen Zhihan , Chen Keliang , Li Yuxin , Geng Daoying , Li Xiantao , Liang Xiaoniu , Lu Huimeng , Ding Saineng , Xiao Zhenxu , Ma Xiaoxi , Zheng Li , Ding Ding , Zhao Qianhua , Yang Liqin ,   for the Alzheimer's Disease Neuroimaging Initiative
Published: November 2023

AbstractMild cognitive impairment (MCI) is a critical prodromal stage of Alzheimer's disease (AD), and the mechanism underlying the conversion is not fully explored. Construction and inter‐cohort validation of imaging biomarkers for predicting MCI conversion is of great challenge at present, due to lack of longitudinal cohorts and poor reproducibility of various study‐specific imaging indices. We proposed a novel framework for inter‐cohort MCI conversion prediction, involving comparison of structural, static, and dynamic functional brain features from structural magnetic resonance imaging (sMRI) and resting‐state functional MRI (fMRI) between MCI converters (MCI_C) and non‐converters (MCI_NC), and support vector machine for construction of prediction models. A total of 218 MCI patients with 3‐year follow‐up outcome were selected from two independent cohorts: Shanghai Memory Study cohort for internal cross‐validation, and Alzheimer's Disease Neuroimaging Initiative (ADNI) cohort for external validation. In comparison with MCI_NC, MCI_C were mainly characterized by atrophy, regional hyperactivity and inter‐network hypo‐connectivity, and dynamic alterations characterized by regional and connectional instability, involving medial temporal lobe (MTL), posterior parietal cortex (PPC), and occipital cortex. All imaging‐based prediction models achieved an area under the curve (AUC) > 0.7 in both cohorts, with the multi‐modality MRI models as the best with excellent performances of AUC > 0.85. Notably, the combination of static and dynamic fMRI resulted in overall better performance as relative to static or dynamic fMRI solely, supporting the contribution of dynamic features. This inter‐cohort validation study provides a new insight into the mechanisms of MCI conversion involving brain dynamics, and paves a way for clinical use of structural and functional MRI biomarkers in future.
Quantum squirrel search algorithm based support vector machine algorithm for brain tumor classification
Authors: Nijaguna G. S. , Kumar D. P. Manoj , Manjunath B. N. , Jain T. J. Swasthika , Dayananda Lal N. 
Published: November 2023

AbstractA Brain tumor is growth or mass of irregular cells inside your brain, several various kinds of brain tumors survive. A few brain tumors are cancerous (malignant), also various brain tumors are noncancerous (benign). The existing approach faces problem related to local optima issues, complexity in computational time, less convergence speed and less exploration ability. The stimulated quality Selection of Quantum Squirrel Search Algorithm (QSSA) is based on equally appearance with methylation information of prostate cancer. Issues with multiple models, multiple dimensions, and unimodal optimization are all addressed by this QSSA concept. The input image of the CE‐MRI dataset consists of 3064 segments with comprise (708 slices) meningiomas, (1426 slices) gliomas and (930 slices) pituitary tumors. In order to extract appropriate data from an image, a convolutional neural network (CNN) executes a number of mathematical processes, including convolutions and pooling. The CNN model's benefits include a large number of important features that can be extracted and good accuracy. Then, Support Vector Machine (SVM), a machine learning technique used for supervised learning, is typically associated within the double classification. The SVM model benefits from a large effective dimensional space and adequate memory. The proposed QSSA has obtained high Accuracy 98.3%, Sensitivity 95.4% and Specificity 97.9% than existing Correlation Learning Mechanism (CLM) which has 90.4% accuracy, 86% sensitivity and 91.5% specificity respectively.
Crosslinking strategies of decellularized extracellular matrix in tissue regeneration
Authors: Qiao Su , Peijie Tan , Nan Jiang 
Published: November 2023

AbstractBy removing the immunogenic cellular components through various decellularization methods, decellularized extracellular matrix (dECM) is considered a promising material in the field of tissue engineering and regenerative medicine with highly preserved physicochemical properties and superior biocompatibility. However, decellularization treatment can lead to some loss of structural integrity, mechanical strength, degradation stability, and biological performance of dECM biomaterials. Therefore, physical and chemical crosslinking methods are preferred to restore or even improve the biomechanical properties, stability, and bioactivity, and to achieve a delicate balance between degradation of the implanted biomaterial and regeneration of the host tissue. This review provides an overview of dECM biomaterials, and describes and compares the mechanisms and characteristics of commonly used crosslinking methods for dECM, with a focus on the potential applications of versatile dECM‐based biomaterials derived from skin, cardiac tissues (pericardium, heart valves, myocardial tissue), blood vessels, liver, and kidney, modified with different chemical crosslinking reagents, in tissue and organ regeneration.
A rationally engineered small antimicrobial peptide with potent antibacterial activity
Authors: Behera Lalita Mohan , Ghosh Manaswini , Gupta Pulkit Kr. , Rana Soumendra 
Published: November 2023

AbstractAntimicrobial resistance (AMR) is a silent pandemic declared by the WHO that requires urgent attention in the post‐COVID world. AMR is a critical public health concern worldwide, potentially affecting people at different stages of life, including the veterinary and agriculture industries. Notably, very few new‐age antimicrobial agents are in the current developmental pipeline. Thus, the design, discovery, and development of new antimicrobial agents are required to address the menace of AMR. Antimicrobial peptides (AMPs) are an important class of antimicrobial agents for combating AMR due to their broad‐spectrum activity and ability to evade AMR through a multimodal mechanism of action. However, molecular size, aggregability, proteolytic degradation, cytotoxicity, and hemolysis activity significantly limit the clinical application of natural AMPs. The de novo design and engineering of a short synthetic amphipathic AMP (≤16 aa, Mol. Wt. ≤ 2 kDa) with an unusual architecture comprised of coded and noncoded amino acids (NCAAs) is presented here, which demonstrates potent antibacterial activity against a few selected bacterial strains mentioned in the WHO priority list. The designer AMP is conformationally ordered in solution and effectively permeabilizes the outer and inner membranes, leading to bacterial growth inhibition and death. Additionally, the peptide is resistant to proteolysis and has negligible cytotoxicity and hemolysis activity up to 150 μM toward cultured human cell lines and erythrocytes. The designer AMP is unique and appears to be a potent therapeutic candidate, which can be subsequently subjected to preclinical studies to explicitly understand and address the menace of AMR.
2α, 3α, 24‐Thrihydroxyurs‐12‐en‐24‐ursolic acid enhances the cytotoxic effect of cisplatin on oral cancer cells by down‐regulating autophagy
Authors: Zhang Wentao , Lu Ruijie , Lv Leyao , Ma Chenxi , Ding Yude , Yang Fan , Fang Qingxia , Wu Yue , Pan Ruolang , Chen Yunfang 
Published: November 2023

AbstractThis study aimed to investigate the effect and mechanism of 2α, 3α, 24‐thrihydroxyurs‐12‐en‐24‐ursolic acid (TEOA) alone or in combination with cisplatin on oral cancer. TEOA, a pentacyclic triterpenoid compound isolated from the roots of Actinidia eriantha, has demonstrated antitumor activity in preclinical experiments. However, its role in oral cancer remains poorly understood. Our findings revealed that a low concentration of TEOA did not exhibit significant cytotoxicity against oral squamous cell carcinoma cells. However, when combined with cisplatin, TEOA showed a significant therapeutic effect. The combined treatments resulted in a significant inhibition of proliferation and migration and a significant increase in apoptosis of squamous cell carcinoma cells. Cisplatin exposure increased autophagy levels, which may contribute to chemoresistance. Of note, the presence of TEOA significantly inhibited cisplatin‐induced autophagy, leading to improved chemotherapy efficacy. Our findings indicate that a mild low dosage of TEOA may enhance the cytotoxic effect of cisplatin by downregulating autophagy in oral cancer cells.
A novel cuproptosis‐related prognostic gene signature in adrenocortical carcinoma
Authors: Gao Wenjun , He Xiaoyan , Huangfu Qi , Xie Yanqi , Chen Keliang , Sun Chengfang , Wei Jingchao , Wang Bohan 
Published: November 2023

AbstractBackgroundAdrenocortical carcinoma (ACC) is an aggressive and rare malignant tumor associated with poor outcomes. Cuproptosis, a new pattern of cell death, relies on mitochondrial respiration and is associated with protein lipoylation. Increasing evidence has demonstrated the potential roles of cuproptosis in several tumor entities. However, the relationship between cuproptosis and ACC remains unclear.MethodsIn total, 10 cuproptosis‐related genes (CRGs) of patients with ACC were obtained from the Gene Expression Omnibus (GEO) and The Cancer Genome Atlas (TCGA) databases and differential expression analysis of CRGs was analyzed. Functional enrichment of the CRGs was performed and protein–protein interaction analysis was utilized to explore the association between the CRGs. Cuproptosis‐related risk score (CRRS) was constructed by Lasso Cox regression and validated.ResultsIn the current study, the alteration and expression patterns of 10 CRGs in TCGA–ACC datasets were analyzed. We identified different expression patterns of CRGs in ACCs, discovered strong associations between CRGs and ACCs, and found that the CRGs were associated with immune infiltration in ACCs. A CRRS was created thereafter to predict overall survival (OS). CRRS = (0.083103718) *FDX1 + (−0.278423862) *LIAS+(0.090985682) *DLAT+(−0.018784047) *PDHA1 + (0.297218951) *MTF1 + (0.310197964) *CDKN2A. Patients were divided into high‐ and low‐risk groups based on their CRRS, and independent prognostic factors were investigated. Finally, CDKN2A and FDX1 were found to be independent prognostic predictors of patients with ACC.ConclusionsCDKN2A and FDX1 are independent prognostic predictors of patients with ACC. Cuproptosis may play a role in the development of ACC, providing a new perspective on therapeutic strategies related to CRGs for cancer prevention and treatment.
Decoupling Between Brain Activity and Cerebrospinal Fluid Movement in Neurological Disorders
Authors: Liu Xiao 
Published: November 2023

Recent research has identified a link between the global mean signal of resting‐state functional MRI (fMRI) and macro‐scale cerebrospinal fluid movement, indicating the potential link between this resting‐state dynamic and brain waste clearance. Consistent with this notion, the strength of this coupling has been associated with multiple neurodegenerative disease pathologies, especially the build‐up of toxic proteins. This article aimed to review the latest advancements in this research area, emphasizing studies on spontaneous global brain activity that is tightly linked to the global mean resting‐state fMRI signal, and aimed to discuss potential mechanisms through which this activity and associated physiological modulations might affect brain waste clearance. The available evidence supports the presence of a highly organized global brain activity that is linked to arousal and memory systems. This global brain dynamic, along with its associated physiological modulations, has the potential to influence brain waste clearance through multiple pathways through multiple pathways.Level of Evidence2Technical EfficacyStage 3
Long‐Term Outcomes of Septoplasty With or Without Turbinoplasty: A Systematic Review
Authors: Fearington Forrest W. , Awadallah Andrew S. , Hamilton Grant S. , Olson Michael D. , Dey Jacob K. 
Published: November 2023

BackgroundSeptoplasty is used to correct nasal obstruction from nasal septum deviation. However, the long‐term efficacy of septoplasty is unclear, and no literature reviews have examined long‐term outcomes of septoplasty with or without turbinate modification. This systematic review aimed to evaluate the long‐term efficacy of septoplasty with or without turbinate modification in improving nasal obstruction.Data SourcesPubMed, EMBASE, Cochrane CENTRAL.MethodsA systematic review of the literature was conducted using the aforementioned databases. Studies reporting outcomes 12+ months after functional septoplasty with or without turbinate surgery for nasal obstruction were included. Septorhinoplasties, concurrent sinus surgery, pediatric studies, and studies where septoplasty was performed for indications other than nasal obstruction were excluded.ResultsAfter screening, 35 studies with 4,432 patients were included. Mean weighted post‐operative follow‐up time was 29.1 months (range 12–120 months). All studies reported significant improvement in subjective and objective outcomes at long‐term follow‐up compared to baseline. When comparing short‐term (<12 months) to long‐term (≥12 months) outcomes, four studies noticed that subjective outcomes worsened slightly over time, but no study found a significant change in objective outcomes over time. In addition, 23 studies reported patient satisfaction and/or improvement rates, with 75.4% (2,348/3,113) of patients expressing satisfaction/improvement at an average of 27.0 months after surgery.ConclusionsOverall, septoplasty with or without turbinate modification shows significant improvement in obstructive symptoms at long‐term follow‐up per both objective and subjective measures. Whether outcomes may worsen slightly over time remains indeterminate based on mixed results in the literature.Level of EvidenceN/A Laryngoscope, 134:2525–2537, 2024
Bi‐directional nasal drug delivery systems: A scoping review of nasal particle deposition patterns and clinical application
Authors: Liu Yuxing , Wu Dawei 
Published: November 2023

AbstractObjectivesTo compare the deposition patterns within the nasal cavity between the bi‐directional and unilateral nasal delivery systems. And to summarize the clinical application of the bi‐directional nasal drug delivery devices.Data sourcePubMed, Cochrane Library, Embase, and Web of Science databases.MethodsA scoping review was conducted according to the Preferred Reporting Items for Systematic Reviews and Meta‐Analysis (PRISMA). We included studies exploring patterns and influencing factors of particle depositions within the nasal cavity among patients, healthy controls, and nose cast models using the bi‐directional and unilateral nasal delivery system. The clinical application of the bi‐directional delivery devices was also summarized.ResultsA total of 24 studies were included in this review. Bi‐directional nasal delivery systems utilize forced exhalation to power the delivery of drugs to deeper areas of the nasal cavity and paranasal sinuses. Unilateral nasal delivery systems included traditional liquid spray pumps, the aerosol mask system, nebulization, and conventional nasal inhalation. Compared with unilateral delivery systems, the bi‐directional nasal delivery system provided a more extensive and efficient nasal deposition in the nasal cavity, especially in the olfactory cleft, without lung deposition. Several parameters, including particle size, pulsatile flow, and nasal geometry, could significantly influence nasal deposition. The bi‐directional nasal delivery system enables better delivery of steroids or sumatriptan to the sinonasal cavity's high and deep target sites. This bi‐directional delivery device demonstrated an effective and well‐tolerated treatment that produced high drug utilization, rapid absorption, and sustained symptom improvement among patients with chronic rhinosinusitis (CRS) or migraine.ConclusionThe bi‐directional nasal drug delivery systems demonstrated significantly higher drug deposition in superior and posterior regions of the nasal cavity than unilateral nasal delivery systems. Further studies should explore its potential role in delivering drugs to the olfactory cleft among patients with olfactory disorders and central nervous system diseases.Level of evidenceN/A.
Reusable and Transparent Impaction‐Based Filter with Micro Apertured Multiscale Polymeric Stencil for Particulate Matter Capture
Authors: Kim Minju , Lee Gahyun , Jang Segeun , Yu Dong In , Kim Sang Moon 
Published: November 2023

AbstractAir pollution by particulate matter (PM) in the air including PM1.0, PM2.5, and PM10, which are categorized by particle size, is a critical global environmental issue, harming the climate, ecosystems, and human health. Especially, ultrafine dust including PM1.0 and PM2.5 poses significant human health risks. Commercial fabric‐based filters effectively trap PMs but cause high‐pressure drop and limited filter capacity and reusability. Electrospun nanofiber filters address some issues but have low mechanical strength, toxic exposure risks, long fabrication times, and restrained reusability. Herein, a reusable and transparent impaction‐based PM filter using a UV‐curable polymeric stencil with micro apertures is proposed. The polymeric stencil filters achieve high filter efficiency (68–94%), superior filter capacity, and low‐pressure drop (<64 Pa). The polymeric stencil filters can be easily cleaned with water or ethanol and remain stable under extreme temperatures (−196 to 450 °C) with slight shrinkage (0–7%). The polymeric stencil filters can be broadly utilized for not only industrial, indoor, and vehicle filters but also transparent and flexible facial health masks.