bluuebunny/crossref_metadata_2025_split huggingface dataset:
A Comparison of the Effects of Acupressure and Music on Venipuncture Pain Intensity in Children: A Randomized Controlled Clinical Trial
Authors: Daihimfar Faezeh , Babamohamadi Hassan , Ghorbani Raheb 
Published: January 2024

Pain from injections is common in children of all ages, and more than 90% of hospitalized children experience invasive and painful procedures such as venipuncture. In light of the complications associated with pain relief medications, nonpharmacological and complementary medicine approaches have gained attention. This study aims to compare the effects of acupressure and music on venipuncture pain intensity in children. This randomized controlled clinical trial involved 180 children aged 3–6 years who sought treatment at the Children’s Medical Center Hospital Emergency Department at Tehran University of Medical Sciences, Iran. The children were randomly assigned to one of three groups: acupressure, music, or control. The interventions were given within 5 minutes, starting 3 minutes before the venipuncture and continuing until completion. The interventions included playing music through headphones and applying acupressure to the Hugo point. Venipuncture was carried out under identical conditions using an Angiocath 24G needle. Pain intensity was assessed using the Oucher scale. Data were analyzed using SPSS 24, employing the Kruskal–Wallis, chi-square, and Bonferroni pairwise comparison tests, with a significance level of 0.05. The mean pain intensity was 3.32 ± 1.44 in the music group, 4.82 ± 1.51 in the acupressure group, and 8.32 ± 1.10 in the control group. Pain intensity significantly differed among the three groups p<0.001. Specifically, pain intensity was lower in the music group compared to both the acupressure p<0.001 and control p<0.001 groups. Furthermore, pain intensity was lower in the acupressure group than in the control group p<0.001. Based on the results, music and acupressure methods effectively reduce pain intensity during venipuncture in children. Considering that music demonstrated a more pronounced effect in alleviating venipuncture pain than acupressure, the recommendation is to utilize music as a method of pain management during venipuncture in children. Iranian Registry of Clinical Trials, Trial No. IRCT20120109008665N15, was registered on 6 December 2021.
The Impact of Circulating Tumor Cell HOXB13 RNA Detection in Men with Metastatic Castration-Resistant Prostate Cancer (mCRPC) Treated with Abiraterone or Enzalutamide
Authors: Halabi Susan , Guo Siyuan , Park Joseph J. , Nanus David M. , George Daniel J. , Antonarakis Emmanuel S. , Danila Daniel Costin , Szmulewitz Russell Zelig , McDonnell Donald P. , Norris John D. , Lu Changxue , Luo Jun , Armstrong Andrew J. 
Published: January 2024

Abstract

Purpose:
HOXB13 is an androgen receptor (AR) coregulator specifically expressed in cells of prostatic lineage. We sought to associate circulating tumor cell (CTC) HOXB13 expression with outcomes in men with mCRPC treated with abiraterone or enzalutamide.

Experimental Design:
We conducted a retrospective analysis of the multicenter prospective PROPHECY trial of mCRPC men (NCT02269982, n = 118) treated with abiraterone/enzalutamide. CTC detection and HOXB13 complementary DNA (cDNA) expression was measured using a modified Adnatest, grouping patients into 3 categories: CTC 0 (undetectable); CTC+ HOXB13 CTC low (&lt;4 copies); or CTC+ HOXB13 CTC high. The HOXB13 threshold was determined by maximally selected rank statistics for prognostic associations with overall survival (OS) and progression-free survival (PFS).

Results:
We included 102 men with sufficient CTC HOXB13 cDNA, identifying 25%, 31%, and 44% of patients who were CTC 0, CTC+ HOXB13 low, and CTC+ HOXB13 high, respectively. Median OS were 25.7, 27.8, and 12.1 months whereas the median PFS were 9.0, 7.7, and 3.8 months, respectively. In subgroup analysis among men with CellSearch CTCs ≥5 copies/mL and adjusting for prior abi/enza treatment and Halabi clinical risk score, the multivariate HR for HOXB13 CTC detection was 2.39 (95% CI, 1.06–5.40) for OS and 2.78 (95% CI, 1.38–5.59) for PFS, respectively. Low HOXB13 CTC detection was associated with lower CTC PSA, PSMA, AR-FL, and AR-V7 detection, and more liver/lung metastases (41% vs. 25%).

Conclusions:
Higher CTC HOXB13 expression is associated with AR-dependent biomarkers in CTCs and is adversely prognostic in the context of potent AR inhibition in men with mCRPC.
Sotorasib Is a Pan-RASG12C Inhibitor Capable of Driving Clinical Response in NRASG12C Cancers
Authors: Rubinson Douglas A. , Tanaka Noritaka , Fece de la Cruz Ferran , Kapner Kevin S. , Rosenthal Michael H. , Norden Bryanna L. , Barnes Haley , Ehnstrom Sara , Morales-Giron Alvin A. , Brais Lauren K. , Lemke Christopher T. , Aguirre Andrew J. , Corcoran Ryan B. 
Published: January 2024

Abstract

KRASG12C inhibitors, like sotorasib and adagrasib, potently and selectively inhibit KRASG12C through a covalent interaction with the mutant cysteine, driving clinical efficacy in KRASG12C tumors. Because amino acid sequences of the three main RAS isoforms—KRAS, NRAS, and HRAS—are highly similar, we hypothesized that some KRASG12C inhibitors might also target NRASG12C and/or HRASG12C, which are less common but critical oncogenic driver mutations in some tumors. Although some inhibitors, like adagrasib, were highly selective for KRASG12C, others also potently inhibited NRASG12C and/or HRASG12C. Notably, sotorasib was five-fold more potent against NRASG12C compared with KRASG12C or HRASG12C. Structural and reciprocal mutagenesis studies suggested that differences in isoform-specific binding are mediated by a single amino acid: Histidine-95 in KRAS (Leucine-95 in NRAS). A patient with NRASG12C colorectal cancer treated with sotorasib and the anti-EGFR antibody panitumumab achieved a marked tumor response, demonstrating that sotorasib can be clinically effective in NRASG12C-mutated tumors.

Significance:
These studies demonstrate that certain KRASG12C inhibitors effectively target all RASG12C mutations and that sotorasib specifically is a potent NRASG12C inhibitor capable of driving clinical responses. These findings have important implications for the treatment of patients with NRASG12C or HRASG12C cancers and could guide design of NRAS or HRAS inhibitors.
See related commentary by Seale and Misale, p. 698.
This article is featured in Selected Articles from This Issue, p. 695
From Consumption to Communion: The Ecclesial Role of Public Theologians in Cultivating a Livable City
Authors: Parker Dylan 
Published: January 2024

Abstract
Urbanism has become the dominant form of human dwelling, giving rise to the concept of livability, accompanied by livability indexes and city rankings. These reports provide brief bragging rights and marketing opportunities for high-ranking cities while glossing over the complex realities and inherent dangers of urban life. The issues surrounding livability rankings reveal corrupted anthropologies that prioritize the ways that one can consume a place rather than the cultivation of communities that are mutually reinforcing in their flourishing. Public theologians must work at the level of theological imagination to reclaim a vocational anthropology that places participation with God in the cultivation of community at the center of what it means to be made in the Image of God. In order to accomplish this fundamental shift, a significant and sometimes overlooked role for public theologians in the world today is serving ecclesial communities in facilitating this imagination through liturgical formation.
Liveability at Risk
Authors: Pearson Clive 
Published: January 2024

Abstract
It is now recognized that the majority of people who will be adversely affected by climate change will live in cities. It is time for a public theology to explore how its resources might be put to use in the service of extreme cities in the era of the Anthropocene. The city of Sydney provides a rather surprising case study for such. Through 2019/2020 it was subject to succession of extreme heat, fire in its surrounds, followed by the pandemic and then five floods. It had just been deemed to be the world’s third most liveable city. In these matters theology is not the lead discipline. It is seldom invoked and invited to be placed along many other fields of knowledge in this knot of transdisciplinary challenges. It has been claimed that the future in the Anthropocene is likely to be ugly and cities will be marked by precarity. It is time for a public theology to consider the potential plight of cities and develop ahead of time – in ordinary time – a pattern of understanding and moral practice. For that to be possible it is critical for such a theology to heed the theoretical work being done in the fields that comprise an Earth System science.
The Circumcising Antichrist in the Credo of Gregory of Tours: Sources, Context, and Influence
Authors: Halfond Gregory I. 
Published: January 2024

Abstract
In the personal credo that prefaces his Decem libri historiarum, Gregory of Tours states his belief in an Antichrist who would impose circumcision upon his subjects. While Gregory did not invent this theme of a circumcising Antichrist, it nevertheless closely mirrored his own eschatological anxieties. Physical circumcision was, for Gregory, an unmistakable indicator of Judaism and the Old Law. The Bishop of Tours was deeply concerned about the Jews of his own time, whose obstinate refusal to acknowledge Christian truth he perceived as an obstacle to his socio-religious ideal of a unified Christian society. While Gregory did not necessarily believe that the End Times would arrive during his own lifetime, he saw signa of its inevitability everywhere, and consequently encouraged readiness on the part of his contemporaries. The Antichrist’s imposition of compulsory circumcision thus implied for Gregory the culmination of an ongoing effort by Jews to inhibit Christian unity.
Examining E10 Strategies and Decisions
Authors: Olsson Louise , Chang Patty , Muvumba Sellström Angela 
Published: January 2024

Abstract
Conventional wisdom dictates the ten elected members (E10) operate within the predominance of the five permanent members (P5) in the UN Security Council. Often also constrained by limited internal resources, many of the E10 need to ensure external support to promote their interests. In research, however, limited theoretical disaggregation exists on E10 strategies and conditions affecting their maneuvering to obtain influence. To address this gap, this article draws on existing research to form a framework and further inform this by using material from Sweden’s term (2017–2018) related to how Sweden sought to contribute to the progress of Women, Peace and Security. The article uses qualitative empirical material from thirty semistructured interviews of Swedish diplomats, other Member States of the Council, UN officials, scholars, and civil society advocates. The utility of this framework demonstrates the efficacy of E10 power, thereby opening up new avenues for future research.
The School of No Fun and No Play: Learning How to Create Supportive Environments from Children with Osteogenesis Imperfecta
Authors: Cleary Brenda , Linds Warren , Carnevale Franco A. , Thorstad Kelly , Rauch Frank , Tsimicalis Argerie 
Published: January 2024

Abstract
Children with medically complex dis/abilities hold sophisticated views on effective school leadership, adapted built environments, inspiring peer solidarity, catalyzing transformational solutions and a possible school-hospital liaison model to support student well-being. Using child-centric collaborative techniques, this ethnodramatic study engaged children with osteogenesis imperfecta (oi), a rare genetic disease, to create a children’s book describing their moral experiences to be disseminated to other children and families. Children living with oi experience ongoing medical interventions and dis/ability that broadly jeopardized the quality of their academic experience relative to their peers. As such, children living with oi offered trenchant insight into what supports and thwarts operationalization of their values and highlights the programs, leadership, services and paradigm shifts they feel that they need to flourish in the academic context.
The 2022 Record-Breaking Heat Event over the Middle and Lower Reaches of the Yangtze River: The Role of Anthropogenic Forcing and Atmospheric Circulation
Authors: Wang Dongqian , Sun Ying , Hu Ting , Yin Hong 
Published: January 2024

Abstract
The anthropogenic forcing and anomalous atmospheric circulation have increased the occurrence probability of 2022-like extreme heat by approximately 62.0 and 2.6 times, respectively.
A Global Climatology of Diabatic Heating in Tropical Easterly Waves
Authors: Lewis-Merritt Carrie , Stachnik Justin P. , Hollis Margaret A. , Martin Elinor R. , McCrary Rachel R. 
Published: January 2024

Abstract
Tropical easterly waves (TEWs) play a critical role in regulating convection and precipitation across the global tropics. TEWs act as seed disturbances for tropical cyclogenesis, serve as an essential component in monsoon precipitation, and produce large amounts of rainfall and diabatic heating that can strongly affect the large-scale circulation. To help improve our knowledge of a more elusive type of tropical wave, we use satellite and reanalysis estimates of the diabatic heating associated with TEWs that are identified by a tracking algorithm based on low-level curvature vorticity. This study uses the Tropical Rainfall Measuring Mission (TRMM) version 6 convective–stratiform heating (CSH) and spectral latent heating (SLH) orbital products to create a global climatology (1998–2015) of TEW diabatic heating. TEW-specific composites for the satellite-observed vertical structure of diabatic heating are compared to similar terms from MERRA-2 across a variety of tropical regions. There are striking differences between the reanalysis and satellite heating with MERRA-2 having much stronger background heating, especially at low levels. Both the satellite-observed and reanalysis heating profiles show stronger midlevel heating associated with TEWs relative to the unconditional background. Similar patterns of mid- and bottom-heaviness emerge in two-dimensional composites of TEW latent heating as stronger heating rates and percent contributions to the background are generally higher at 500 hPa than at 850 hPa. Although TEWs only represent a few percent of the background heating across the global tropics, they comprise 30%–50% of the heating in the prominent TEW tracks over the northeastern Atlantic and Pacific Oceans.
Renewable Energy and Economic Growth: Evidence from India
Authors: Gupta Rajesh , Guha Atulan 
Published: January 2024

This article examines the nexus between economic growth and two renewable energy sources, namely wind and solar, to separate out the contrast between these two sources, for India deploying system generalised method of moments and vector error correction method suitable to capture the dynamic nature of panel data. Unlike most of the earlier studies, it takes into account cross-sectional dependence and addresses the issue of endogeneity. India has been chosen because despite India being one of the largest producers of renewable energy globally; the nexus is under-studied. This article finds the installation of solar energy capacity positively influences the Gross State Domestic Product (GSDP) growth. Moreover, there is a bi-directional positive relation between the installation of wind energy capacity and GSDP growth. Hence the adoption of renewable energy is helping the states to grow faster. However, the study found not much difference in the nature of the nexus between solar energy growth and wind energy growth for India. JEL Codes: O13, P28, P44, Q56
Eliciting Risk Perceptions: Does Conditional Question Wording Have a Downside?
Authors: Strueder Jeremy D. , Miller Jane E. , Yu Xianshen , Windschitl Paul D. 
Published: January 2024

Background To assess the impact of risk perceptions on prevention efforts or behavior change, best practices involve conditional risk measures, which ask people to estimate their risk contingent on a course of action (e.g., “if not vaccinated”). Purpose To determine whether the use of conditional wording—and its drawing of attention to one specific contingency—has an important downside that could lead researchers to overestimate the true relationship between perceptions of risk and intended prevention behavior. Methods In an online experiment, US participants from Amazon’s MTurk ( N = 750) were presented with information about an unfamiliar fungal disease and then randomly assigned among 3 conditions. In all conditions, participants were asked to estimate their risk for the disease (i.e., subjective likelihood) and to decide whether they would get vaccinated. In 2 conditional-wording conditions (1 of which involved a delayed decision), participants were asked about their risk if they did not get vaccinated. For an unconditional/benchmark condition, this conditional was not explicitly stated but was still formally applicable because participants had not yet been informed that a vaccine was even available for this disease. Results When people gave risk estimates to a conditionally worded risk question after making a decision, the observed relationship between perceived risk and prevention decisions was inflated (relative to in the unconditional/benchmark condition). Conclusions The use of conditionals in risk questions can lead to overestimates of the impact of perceived risk on prevention decisions but not necessarily to a degree that should call for their omission. Highlights Conditional wording, which is commonly recommended for eliciting risk perceptions, has a potential downside. It can produce overestimates of the true relationship between perceived risk and prevention behavior, as established in the current work. Though concerning, the biasing effect of conditional wording was small—relative to the measurement benefits that conditioning usually provides—and should not deter researchers from conditioning risk perceptions. More research is needed to determine when the biasing impact of conditional wording is strongest.
To Evaluate Correlation Between Cervical Vertebral Maturation Stages and Third Molar Maturation Stages in North Maharashtrian Population
Authors: Chaugule Akshay Sunil , Patil Kunal Bhaskar , Nagmode Sunilkumar Laxman , Aphale Hrushikesh Subhash , Shinde Vivek Jayaram , Surana Sejal Pravin 
Published: January 2024

Introduction Assessment of growth is crucial in the diagnosis and treatment planning in orthodontics. Skeletal development can be assessed by using hand-wrist radiographs and lateral cephalograms. The advantage of the panoramic radiograph over hand wrist radiograph is that patient exposure is reduced following the ALARA principle. Aim The aim of this study was to investigate the correlation between third molar calcification stages and skeletal maturity using the CVM stages in North Maharashtrian population. Methods Dental panoramic and lateral cephalograms of subjects ranged in age from 9 to 20 years were selected. Demirjians method was used to assess the dental maturation stages of third molars on both the sides. Hassel and Farman classification was used for classifying into cervical vertebral maturation indicator stages. The collected data were statistically analyzed. Result There was a statistically significant correlation between cervical maturation stages and third molar calcification stages in North Maharashtrian population.
Cardiovascular Safety of Amphetamine/Dextroamphetamine versus Methylphenidate in Older Adults
Authors: Paulmann Rachel , Stouffer Randi , Mathys Monica , Weideman Rick , Alvarez Carlos , Yang Hui 
Published: January 2024

Background: Recent epidemiological data has shown a sharp increase in stimulant use among older adults, which is notable as older adults may be especially vulnerable to their cardiovascular effects. Results of recent studies have shown an increase in cardiovascular events among older adults using stimulants; however, little data exists comparing cardiovascular safety of these agents head-to-head. Objective: To determine if the incidence of serious cardiovascular events, including myocardial infarction (MI), stroke/transient ischemic attack (TIA), or arrhythmia, are different in patients taking amphetamine/dextroamphetamine compared with patients taking methylphenidate. Methods: Retrospective chart review of veterans 50 years and older at the Veterans Affairs North Texas Health Care System (VANTHCS) who were first prescribed a stimulant between 2015 and 2021. The primary outcome was the difference in composite cardiovascular events between amphetamine/dextroamphetamine and methylphenidate. Secondary outcomes were the composite cardiovascular endpoints compared individually (MI, stroke/TIA, or arrhythmia). Hazard ratios were calculated based off of a time-to-event analysis displayed using a Kaplan-Meier curve for primary and secondary outcomes. Results: 466 veterans were screened for inclusion, 30 were excluded, and 436 were included. There was no difference found in composite cardiovascular events between the 241 veterans in the amphetamine/dextroamphetamine group and the 195 veterans in the methylphenidate group with 12 (5%) vs 8 (4.1%) events respectively ( P = .6635). There was also no difference in time-to-event analysis ( P = .4966). Conclusion: In elderly veterans, there was no difference found in incidence of major cardiovascular events with the use of amphetamine/dextroamphetamine compared with methylphenidate.
Simple recognition of hand gestures using single-channel EMG signals
Authors: Pourmokhtari Mina , Beigzadeh Borhan 
Published: January 2024

Electromyography (EMG) signals are used for many different purposes, such as recording and measuring the electrical activity generated by varying the body’s skeletal muscles. Biosignals are different types of biomedical signals, like EMG signals, which can be used for the neural linkage with computers and are obtained from a particular part of the body such as tissue, muscle, organ, or cell system like the nervous system. Surface electromyography (SEMG) is a non-invasive method that can be used as an effective system for controlling upper arm prostheses. This study focused on classifying the five types of distinct finger movements investigated in four unique channels. We have used a classification technique, the k-nearest neighbors (KNN), to categorize the collected samples. Two time-domain features, (a) maximum (Max) and (b) minimum (Min), were used with one of these three features separately: mean absolute value (MAV), root mean square (RMS), and simple square integral (SSI) to classify gestures. We chose classification accuracy as a criterion for evaluating the effectiveness of every classification. We figured out that the first grouping, that is, (MAV, Max, Min), was the best choice for classification. The accuracy percentage in the four channels for the first group was 91.0%, 89.9%, 89.8%, and 96.0%, respectively.