bluuebunny/crossref_metadata_2025_split huggingface dataset:
RocHealthData.org: Development and usage of a publicly available, geographic source of social determinants of health data
Authors: Holt Kathleen D. , Roman Gretchen , McIntosh Laura , Kleinsorge Jamie , Holden-Wiltse Jeanne , Bennett Nancy M. 
Published: February 2024

Abstract
Access to local, population specific, and timely data is vital in understanding factors that impact population health. The impact of place (neighborhood, census tract, and city) is particularly important in understanding the Social Determinants of Health. The University of Rochester Medical Center’s Clinical and Translational Science Institute created the web-based tool RocHealthData.org to provide access to thousands of geographically displayed publicly available health-related datasets. The site has also hosted a variety of locally curated datasets (eg., COVID-19 vaccination rates and community-derived health indicators), helping set community priorities and impacting outcomes. Usage statistics (available through Google Analytics) show returning visitors with a lower bounce rate (leaving a site after a single page access) and spent longer at the site than new visitors. Of the currently registered 1033 users, 51.7% were from within our host university, 20.1% were from another educational institution, and 28.2% identified as community members. Our assessments indicate that these data are useful and valued across a variety of domains. Continuing site improvement depends on new sources of locally relevant data, as well as increased usage of data beyond our local region.
Astronomy, Architecture, and Landscape in the Olmec Area and Western Maya Lowlands: Implications for Understanding Regional Variability and Evolution of Orientation Patterns in Mesoamerica
Authors: Šprajc Ivan , Inomata Takeshi 
Published: February 2024

AbstractIn the area along the southern Gulf Coast in Mexico, a large number of previously unrecorded archaeological sites have recently been detected with the aid of lidar data, which also allowed us to determine the orientations of hundreds of structures and architectural assemblages, including many standardized complexes dated to the Early-to-Middle Formative transition. As revealed by our analyses, most orientations were based on astronomical and calendrical principles, occasionally combined with certain concepts of sacred geography. While the results of these analyses were presented in a recently published article, here we explore the potential of alignment data for addressing other questions of archaeological relevance. The distribution of particular building types and regional variations in alignment patterns in the study area suggest the existence of two somehow different cultural spheres, loosely corresponding to the areas conventionally called the Gulf Olmec region and the western Maya Lowlands. Examining pertinent evidence, we argue that it was in this area where some of the most prominent orientation groups materialized in later Mesoamerican architecture originated. We also attempt to reconstruct the paths of their diffusion, which are expected to contribute to understanding the dynamics of long-distance cultural interaction in Mesoamerica.
Including clover and herb species in grazing forages – effects on milk production, milk processability and milk fatty acid profile of late lactation dairy cows supplemented with grass silage and concentrate
Authors: McCarthy K. M. , Walsh N. , Serra E. , Fahey A. G. , Lynch M. B. , Pierce K. M. , Boland T. M. , Sheridan H. , Markiewicz-Keszycka M. , Mulligan F. J. 
Published: February 2024

AbstractMilk production declines as dairy cows enter late lactation, resulting in reduced milk quality and negatively impacting milk processability, such as rennet coagulation time (RCT), milk pH and ethanol stability (ES), leading to seasonality issues for milk processors. Multispecies forages, containing grass, legume and herb species, require lower N inputs and are of interest to dairy farmers. However, little is known about the effect of grazing multispecies forages on milk processability characteristics in late lactation dairy cows. Forty-five autumn-calving dairy cows in late lactation were allocated to 1 of 3 grazing forages; perennial ryegrass (PRG; Lolium perenne), perennial ryegrass and white clover (Trifolium pratense) (PRGWC), and a 6 – species multispecies forage (MULTI) containing perennial ryegrass, timothy (Phleum pratense), white clover, red clover (Trifolium repens), chicory (Cichorium intybus) and plantain (Plantago lanceolata). Cows were allocated 12 kg DM grazed forage and supplemented with a grass – silage TMR and concentrate. Forage DMI was significantly lower for cows grazing PRG. Milk yield increased when cows grazed PRGWC (18.07 kg/d) and MULTI (17.84 kg/d) compared to PRG (16.08 kg/d). Milk RCT (mins) and ES (%) were unaffected by treatment. However, offering cows PRGWC and MULTI increased the concentration of C18:2 cis – 9, 12 and C18:3 cis – 9, 12, 15 in milk compared to PRG. Compared to PRG, grazing forages containing clover and herb species improved milk yield and beneficially altered milk fatty acid profile in late lactation dairy cows without negatively impacting milk processability.
Outbreak of Mycoplasma pneumoniae pneumonia in hospitalized patients: Who is concerned? Nord Franche-Comté Hospital, France, 2023–2024
Authors: Zayet Souheil , Poloni Samantha , Plantin Julie , Hamani Abdoulaye , Meckert Yann , Lavoignet Charles-Eric , Gendrin Vincent , Klopfenstein Timothée 
Published: February 2024

Abstract
We report an outbreak of confirmed Mycoplasma pneumoniae community-acquired pneumonia (CAP) in Nord Franche-Comté Hospital, France, from 14 November 2023 to 31 January 2024. All 13 inpatients (11 adults with a mean age of 45.5 years and 2 children) were diagnosed with positive serology and/or positive reverse transcription polymerase chain reaction (RT-PCR) on respiratory specimens. All patients were immunocompetent and required oxygen support with a mean duration of oxygen support of 6.2 days. Two patients were transferred to the intensive care unit (ICU) but were not mechanically ventilated. Patients were treated with macrolides (n = 12, 92.3%) with recovery in all cases. No significant epidemiological link was reported in these patients.
The relationship between social media addiction and emotional appetite: a cross-sectional study among young adults in Turkey
Authors: Sevim Sumeyra , Gumus Damla , Kizil Mevlude 
Published: February 2024

AbstractObjective:The present study focused on the relationship between addiction to social media (SM) and emotional appetite in young adults.Design:Cross-sectional online survey.Setting:The Bergen Social Media Addiction Scale (BSMAS) and Emotional Appetite Questionnaire (EMAQ) were used, and the duration and frequency of SM tools usage were analysed.Participants:Five hundred and twenty-four participants (144 men and 380 women) aged between 18 and 25 years.Results:The mean of SM usage duration of participants was 3·2 ± 2·2 h per d along with a mean of BSMAS score of 16·1 ± 5·9. Concerning emotional appetite, the mean scores for positive and negative aspects of EMAQ were 4·4 ± 1·9 and 3·1 ± 1·2, respectively. The predominant SM tools were YouTube (92·6 %) and Instagram (90·3 %). Notably, a significant association was observed between SM addiction and the frequency of access to YouTube, Instagram, and Twitter, with addiction levels increasing as access frequency rose (P< 0·01).Conclusion:This study demonstrated a possible relationship between SM addiction and emotional appetite among young adults. However, further research with more prominent participants and a lengthier follow-up duration is necessary to elucidate how SM tools affect eating behaviour.
Modelling and commissioning validation of eclipse conical cone collimator for stereotactic radiosurgery using Monte Carlo simulation
Authors: Shende Ravindra , Dhoble S. J. , Saroj Dinesh , Gupta Gourav 
Published: February 2024

Abstract

Purpose:
The miniaturized conical cones for stereotactic radiosurgery (SRS) make it challenging in measurement of dosimetric data needed for commissioning of treatment planning system. This study aims at validating dosimetric characteristics of conical cone collimator manufactured by Varian using Monte Carlo (MC) simulation technique.

Methods & Material:
Percentage depth dose (PDD), tissue maximum ratio (TMR), lateral dose profile (LDP) and output factor (OF) were measured for cones with diameters of 5mm, 7·5mm, 10mm, 12·5 mm, 15 mm and 17·5 mm using EDGE detector for 6MV flattening filter-free (FFF) beam from Truebeam linac. Similarly, MC modelling of linac for 6MVFFF beam and simulation of conical cones were performed in PRIMO. Subsequently, measured beam data were validated by comparing them with results obtained from MC simulation.

Results:
The measured and MC-simulated PDDs or TMRs showed close agreement within 3% except for cone of 5mm diameter. Deviations between measured and simulated PDDs or TMRs were substantially higher for 5mm cone. The maximum deviations at depth of 10cm, 20cm and at range of 50% dose were found 4·05%, 7·52%, 5·52% for PDD and 4·04%, 7·03%, 5·23% for TMR with 5mm cone, respectively. The measured LDPs acquired for all the cones showed close agreement with MC LDPs except in penumbra region around 80% and 20% dose profile. Measured and MC full-width half maxima of dose profiles agreed with nominal cone size within ± 0·2 mm. Measured and MC OFs showed excellent agreement for cone sizes ≥10 mm. However, deviation consistently increases as the size of the cone gets smaller.

Findings:
MC model of conical cones for SRS has been presented and validated. Very good agreement was found between experimentally measured and MC-simulated data. The dosimetry dataset obtained in this study validated using MC model may be used to benchmark beam data measured for commissioning of SRS for cone planning.
Relationship Between Actual Intelligence & the CAMCOG-R in Cognitively Normal Elders
Authors: Heinik Jeremia 
Published: February 2024

Abstract: We examined (1) the relationship between actual intelligence and the CAMCOG-R performance in cognitively normal elders and (2) the presumed impact of age and education on the relationship. Our retrospective study of 94 participants assessed in a specialized setting, measuring actual intelligence (general and specific) with the Wechsler Adult Intelligence Scale-III, the Full-Scale Intelligence Quotient (WAIS-III FSIQ), and the specific subtests thereof. The CAMCOG-R correlated largely with FSIQ (.629, p < .001; .708 when controlled for age). The CAMCOG-R’s scores increased across three different IQ levels as IQ increased. FSIQ accounted for 40% of the CAMCOG-R’s variability. Combined, FSIQ and age accounted for 59% of the CAMCOG-R’s variability. FSIQ had a stronger weight than age (β: .644 and −.439, respectively). Regression analyses with FSIQ’s subtests, age and education, found the best-equilibrated model to include Information, age, and Picture Completion. Combined, they accounted for 55% of the CAMCOG-R’s variability. Information received the strongest weight (β: .411). Overall, education was nonsignificant. Thus, a significant relationship existed primarily between general intelligence and the CAMCOG-R and, to a lesser extent, between the above-mentioned subtests of intelligence and the CAMCOG-R. Adding age increased the prediction rate. Actual intelligence and age should be considered when interpreting the CAMCOG-R’s scores. The practical implementation of the intelligence factor is complex.
How Hydrothermal Cooling and Magmatic Sill Intrusions Control Flip‐Flop Faulting at Ultraslow‐Spreading Mid‐Ocean Ridges
Authors: Glink Arne , Hasenclever Jörg 
Published: February 2024

Abstract“Flip‐flop” detachment mode represents an endmember type of lithosphere‐scale faulting observed at almost amagmatic sections of ultraslow‐spreading mid‐ocean ridges. Recent numerical experiments using an imposed steady temperature structure show that an axial temperature maximum is essential to trigger flip‐flop faults by focusing flexural strain in the footwall of the active fault. However, ridge segments without significant melt budget are more likely to be in a transient thermal state controlled, at least partly, by the faulting dynamics themselves. Therefore, we investigate which processes control the thermal structure of the lithosphere and how feedbacks with the deformation mechanisms can explain observed faulting patterns. We present results of 2‐D thermo‐mechanical numerical modeling including serpentinization reactions and dynamic grain size evolution. The model features a novel form of parametrized hydrothermal cooling along fault zones as well as the thermal and rheological effects of periodic sill intrusions. We find that the interplay of hydrothermal fault zone cooling and periodic sill intrusions in the footwall facilitates the flip‐flop detachment mode. Hydrothermal cooling of the fault zone pushes the temperature maximum into the footwall, while intrusions near the temperature maximum further weaken the rock and promote the formation of new faults with opposite polarity. Our model allows us to put constraints on the magnitude of two processes, and we obtain most reasonable melt budgets and hydrothermal heat fluxes if both are considered. Furthermore, we frequently observe two other faulting modes in our experiments complementing flip‐flop faulting to yield a potentially more robust alternative interpretation for existing observations.
A Global Survey of Gravitationally Deformed Volcanoes on Venus
Authors: Hahn Rebecca M. , Byrne Paul K. 
Published: February 2024

AbstractGravitational instabilities can develop at volcanoes of any size and in any geological setting and can lead to various types of volcano deformation, ranging from small‐scale landslides on the flanks of the edifice to large, deep‐seated sector collapses. As volcanoes grow, they impose an increasing load on the underlying basement, which can result in styles of gravitational deformation where the edifice sags or spreads outward under its own weight. In this study, we utilize our previously developed global catalog of volcanoes on Venus to analyze a subset of edifices that appears to have undergone gravitational deformation. We identify 162 volcanoes that display morphological evidence for gravitational deformation and classify them into four main categories based on associated deformational structures: landsliding, sector collapse, spreading, and sagging. Landsliding of volcano flanks or full sector collapse are the most common and geographically widespread deformational styles on Venus, and account for ∼64% of our data set. Edifices exhibiting structures linked to volcano spreading and sagging are relatively rare; nonetheless, we note for the first time on Venus the presence on a shield volcano of flank terraces, structures linked to sagging. We find that deformed volcanoes are distributed globally, are found at a range of elevations, are spatially proximal to a variety of tectonic structures, and are associated with various crustal thickness values, which together suggest that there are numerous drivers of volcano deformation on Venus.
Farnesoid X receptor promotes non-small cell lung cancer metastasis by activating Jak2/STAT3 signaling via transactivation of IL-6ST and IL-6 genes
Authors: Jin Xiuye , Shang Bin , Wang Junren , Sun Jian , Li Jing , Liang Bin , Wang Xingguang , Su Lili , You Wenjie , Jiang Shujuan 
Published: February 2024

AbstractMetastasis accounts for the majority of cases of cancer recurrence and death in patients with advanced non-small cell lung cancer (NSCLC). Farnesoid X Receptor (FXR) is a bile acid nuclear receptor that was recently found to be upregulated in NSCLC tissues. However, whether and how FXR regulates NSCLC metastasis remains unclear. In the present study, it was found that FXR promoted the migration, invasion, and angiogenic ability of NSCLC cells in vitro, and increased NSCLC metastasis in a mouse model in vivo. Mechanistic investigation demonstrated that FXR specifically bound to the promoters of IL-6ST and IL-6 genes to upregulate their transcription, thereby leading to activation of the Jak2/STAT3 signaling pathway, which facilitated tumor migration, invasion, and angiogenesis in NSCLC. Notably, Z-guggulsterone, a natural FXR inhibitor, significantly reduced FXRhigh NSCLC metastasis, and decreased the expression of FXR, IL-6, IL-6ST, and p-STAT3 in the mouse model. Clinical analysis verified that FXR was positively correlated with IL-6, IL-6ST and p-STAT3 expression in NSCLC patients, and was indicative of a poor prognosis. Collectively, these results highlight a novel FXR-induced IL-6/IL-6ST/Jak2/STAT3 axis in NSCLC metastasis, and a promising therapeutic means for treating FXRhigh metastatic NSCLC.
Comparison of the effects of renal denervation at early or advanced stages of hypertension on cardiac, renal, and adipose tissue pathology in Dahl salt-sensitive rats
Authors: Nagata Kohzo , Tagami Kaito , Okuzawa Touko , Hayakawa Misaki , Nomura Akane , Nishimura Tomo , Ikeda Katsuhide , Kitada Kento , Kobuchi Shuhei , Fujisawa Yoshihide , Nishiyama Akira , Murohara Toyoaki 
Published: February 2024

AbstractRenal denervation (RDN) has emerged as a novel therapy for drug-resistant hypertension. We here examined the effects of RDN at early versus advanced stages of hypertension on blood pressure and organ pathology in rats with salt-sensitive hypertension. Dahl salt-sensitive (DahlS) rats fed an 8% NaCl diet from 6 weeks of age were subjected to RDN (surgical ablation and application of 10% phenol in ethanol) or sham surgery at 7 (early stage) or 9 (advanced stage) weeks and were studied at 12 weeks. RDN at early or advanced stages resulted in a moderate lowering of blood pressure. Although RDN at neither stage affected left ventricular (LV) and cardiomyocyte hypertrophy, it ameliorated LV diastolic dysfunction, fibrosis, and inflammation at both stages. Intervention at both stages also attenuated renal injury as well as downregulated the expression of angiotensinogen and angiotensin-converting enzyme (ACE) genes and angiotensin II type 1 receptor protein in the kidney. Furthermore, RDN at both stages inhibited proinflammatory gene expression in adipose tissue. The early intervention reduced both visceral fat mass and adipocyte size in association with downregulation of angiotensinogen and ACE gene expression. In contrast, the late intervention increased fat mass without affecting adipocyte size as well as attenuated angiotensinogen and ACE gene expression. Our results thus indicate that RDN at early or late stages after salt loading moderately alleviated hypertension and substantially ameliorated cardiac and renal injury and adipose tissue inflammation in DahlS rats. They also suggest that cross talk among the kidney, cardiovascular system, and adipose tissue may contribute to salt-sensitive hypertension.
Are the results of open randomised controlled trials comparing antipsychotic drugs in schizophrenia biased? Exploratory meta- and subgroup analysis
Authors: Leucht Stefan , Siafis Spyridon , Schneider-Thoma Johannes , Tajika Aran , Priller Josef , Davis John M. , Furukawa Toshi A. 
Published: February 2024

AbstractA recent meta-epidemiological study did not reveal major differences between the results of blinded and open randomised-controlled trials (RCTs). Fewer patients may consent to double-blind RCTs than to open RCTs, compromising generalisability, making this question very important. However, the issue has not been addressed in schizophrenia. We used a database of randomised, acute-phase antipsychotic drug trials. Whenever at least one open and one blinded RCT was available for a comparison of two drugs, we contrasted the results by random-effects meta-analysis with subgroup tests. The primary outcome was overall symptoms as measured by the Positive and Negative Syndrome Scale, supplemented by seven secondary efficacy and side-effect outcomes. We also examined whether open RCTs were biased in favour of more recently introduced antipsychotics, less efficacious or more prone to side-effects antipsychotics, and pharmaceutical sponsors. 183 RCTs (155 blinded and 28 open) with 34715 participants comparing two active drugs were available. The results did not suggest general differences between open and blinded RCTs, which examined two active drugs. Only 12 out of 122 subgroup tests had a p-value below 0.1, four below 0.05, and if a Bonferroni correction for multiple tests had been applied, only one would have been significant. There were some exceptions which, however, did not always confirm the originally hypothesized direction of bias. Due to the relatively small number of open RCTs, our analysis is exploratory, but this fundamental question should be given more scientific attention. Currently, open RCTs should be excluded from meta-analyses, at least in sensitivity analyses.
Profiles of mathematical deficits in children with dyslexia
Authors: Pedemonte B. , Pereira C. W. , Borghesani V. , Ebbert M. , Allen I. E. , Pinheiro-Chagas P. , De Leon J. , Miller Z. , Tee B. L. , Gorno-Tempini M. L. 
Published: February 2024

AbstractDespite a high rate of concurrent mathematical difficulties among children with dyslexia, we still have limited information regarding the prevalence and severity of mathematical deficits in this population. To address this gap, we developed a comprehensive battery of cognitive tests, known as the UCSF Mathematical Cognition Battery (MCB), with the aim of identifying deficits in four distinct mathematical domains: number processing, arithmetical procedures, arithmetic facts retrieval, and geometrical abilities. The mathematical abilities of a cohort of 75 children referred to the UCSF Dyslexia Center with a diagnosis of dyslexia, along with 18 typically developing controls aged 7 to 16, were initially evaluated using a behavioral neurology approach. A team of professional clinicians classified the 75 children with dyslexia into five groups, based on parents’ and teachers’ reported symptoms and clinical history. These groups included children with no mathematical deficits and children with mathematical deficits in number processing, arithmetical procedures, arithmetic facts retrieval, or geometrical abilities. Subsequently, the children underwent evaluation using the MCB to determine concordance with the clinicians’ impressions. Additionally, neuropsychological and cognitive standardized tests were administered. Our study reveals that within a cohort of children with dyslexia, 66% exhibit mathematical deficits, and among those with mathematical deficits, there is heterogeneity in the nature of these deficits. If these findings are confirmed in larger samples, they can potentially pave the way for new diagnostic approaches, consistent subtype classification, and, ultimately personalized interventions.