bluuebunny/crossref_metadata_2025_split huggingface dataset:
High-precision reconstruction method based on MTS-GAN for electromagnetic environment data in SAGIoT
Authors: Guo Lantu , Liu Yuchao , Li Yuqian , Yang Kai 
Published: December 2023

AbstractEquipment failures and communication interruptions of satellites, aircraft and ground devices lead to data loss in Space-Air-Ground Integrated Internet of Things (SAGIoT). The incomplete data affect the accuracy of data modeling, decision-making and spectrum prediction. Reconstructing the incomplete data of electromagnetic environment is a significant task in the SAGIoT. Most spectral data completion algorithms have the problem of limited accuracy and slow iterative optimization. In light of these challenges, a novel high-precision reconstruction method for electromagnetic environment data based on multi-component time series generation adversarial network (MTS-GAN) is proposed in this paper. MTS-GAN transforms the reconstruction method of electromagnetic environment data into the data generation problem of multiple time series. It extracts the time–frequency joint features and the overall distribution of electromagnetic environment data. To improve the reconstruction precision, MTS-GAN simulates the time irregularity of incomplete time series by applying a gate recursive element to adapt to the attenuation effect of discontinuous time series observations. Experimental results show that the proposed MTS-GAN provides high completion accuracy and achieves better results than competitive data completion algorithms.
Evaluation of antibody drug delivery efficiency via nebulizer in various airway models and breathing patterns
Authors: Hong Soon Woo , Chang Kyung Hwa , Woo Chang Jae , Kim Ho Chul , Kwak Bong Seop , Park Bong Joo , Nam Ki Chang 
Published: December 2023

Abstract
Background
Nebulizers are commonly used to treat respiratory diseases, which are a major cause of morbidity and mortality. While inhalation therapy with antibodies has been evaluated in preclinical studies and clinical trials for respiratory diseases, it has not yet been approved for treatment. Moreover, there is limited information regarding the delivery efficiency of therapeutic antibodies via nebulizer.

Methods
In this study, the nebulization characteristics and drug delivery efficiencies were compared when immunoglobulin G (IgG) was delivered by five nebulizers using two airway models and five breathing patterns. The study confirmed that the delivered dose and drug delivery efficiency were reduced in the child model compared to those in the adult model and in the asthma pattern compared to those in the normal breathing pattern.

Results
The NE-SM1 NEPLUS vibrating mesh nebulizer demonstrated the highest delivery efficiency when calculated as a percentage of the loading dose, whereas the PARI BOY SX + LC SPRINT (breath-enhanced) jet nebulizer had the highest delivery efficiency when calculated as a percentage of the emitted dose.

Conclusion
The results suggest that the total inspiration volume, output rate, and particle size should be considered when IgG nebulization is used. We, therefore, propose a method for evaluating the efficiency of nebulizer for predicting antibody drug delivery.
Temperature and microclimate refugia use influence migratory timings of a threatened grassland bird
Authors: Ramos Rita F. , Franco Aldina M.A. , Gilroy James J. , Silva João P. 
Published: December 2023

Abstract
Background
Seasonal changes in resource availability are known to influence the migratory behaviour of animals, including both timing and distance. While the influence of environmental cues on migratory behaviour has been widely studied at the population level, it has rarely been examined at the spatial scale at which individuals experience their environment. Here, we test the hypothesis that individuals exposed to similar large-scale environmental cues may vary in migratory behaviour in response to the different microclimate conditions they experience at fine scales.

Methods
We combine high-spatial and temporal resolution microclimate and habitat information with GPS tracking data for a partially migratory threatened grassland bird. Data from 47 little bustards (Tetrax tetrax; 67 breeding events) tracked between 2009 and 2019 was used to (i) evaluate individual consistency in migratory behaviour (timing and distance) and (ii) assess whether the local environmental characteristics experienced by individuals – and in particular their use of microclimate refugia - influence distance and timing of migration, from and to the breeding sites.

Results
Migratory distance was consistent for birds tracked over multiple years, while the timing of migration showed high variability among individuals. Departures from breeding areas spanned from May to August, with a few birds remaining in their breeding areas. Vegetation greenness (a proxy for food availability) was positively associated with the time birds spent in the breeding area. The best model also included a positive effect of microclimate refugia availability on breeding season length, although an interaction with temperature suggested that this effect did not occur at the highest relative temperatures. The return date to breeding grounds, although spanning from September to April, was not influenced by the environmental conditions or food availability.

Conclusions
Food availability, measured by a vegetation greenness proxy, was associated with later migration at the end of the breeding season. Availability of cooler microclimate refugia may also allow for later departures from the breeding sites in all but the hottest conditions. Management measures that increase microclimate refugia availability and provide foraging resources can thus potentially increase the length of the breeding season for this species.
Protection of navy-bean bioactive peptides within nanoliposomes: morphological, structural and biological changes
Authors: Namdar Nazila Zeynali , Roufegarinejad Leila , Alizadeh Ainaz , Asefi Narmela , Jafari Seid Mahdi , Sarabandi Khashayar 
Published: December 2023

AbstractThis study aimed to produce bioactive peptides from navy-bean protein with alcalase and pepsin enzymes (30–300 min) and to load them into a nanoliposome system to stabilize and improve their bioavailability. The degree of hydrolysis and biological activities (scavenging of DPPH, OH, and ABTS free radicals, reducing power, and chelating metal ions) of navy-bean protein were affected by the type of enzyme and hydrolysis time. The average particle size (83–116 nm), PDI (0.23–0.39), zeta potential (− 13 to − 20 mV), and encapsulation efficiency (80–91%) of nanoliposomes were influenced by the type and charge of peptides. The storage temperature and the type of loaded peptide greatly affected the physical stability of nanocarriers and maintaining EE during storage. The FTIR results suggested the effect of enzymatic hydrolysis on the secondary structures of protein and the effective placement of peptides inside polar-regions and the phospholipid monolayer membrane. SEM images showed relatively uniform-sized particles with irregular structures, which confirmed the results of DLS. The antioxidant activity of primary peptides affected the free radical scavenging of loaded nanoliposomes. Liposomes loaded with navy-bean peptides can be used as a health-giving formula in enriching all kinds of drinks, desserts, confectionery products, etc.
Graphical Abstract
A simulation study of the system characteristics for a long axial FOV PET design based on monolithic BGO flat panels compared with a pixelated LSO cylindrical design
Authors: Dadgar Meysam , Maebe Jens , Abi Akl Maya , Vervenne Boris , Vandenberghe Stefaan 
Published: December 2023

Abstract

Background

Although a new generation of tomographs with a longer axial field-of-view called total-body PET have been developed, they are not widely utilized due to their high cost compared to conventional scanners. The newly designed walk-through total-body PET scanner is introduced as a high-throughput and cost-efficient alternative to total-body PET scanners, by making use of a flat panel geometry and lower cost, depth-of-interaction capable, monolithic BGO detectors. The main aim of the presented study is to evaluate through Monte Carlo simulation the system characteristics of the walk-through total-body PET scanner by comparing it with a Quadra-like total-body PET of similar attributes to the Siemens Biograph Vision Quadra.

Methods

The walk-through total-body PET is comprised of two flat detector panels, spaced 50 cm apart. Each panel, 70 $$\times$$
×
106 cm$$^2$$

2

in size, consists of 280 BGO-based monolithic detectors. The Quadra-like TB-PET has been simulated based on the characteristics of the Biograph Vision Quadra, one of the most common total-body PET scanners with 106 cm of axial field-of-view, which is constructed with pixelated LSO scintillation crystals. The spatial resolution, sensitivity, count rate performance, scatter fractions, and image quality of both scanners are simulated in the GATE simulation toolkit for comparison.

Results

Due to the DOI-capable detectors used in the walk-through total-body PET, the values of the spatial resolution of this scanner were all below 2 mm along directions parallel to the panels, and reached a maximum of 3.36 mm in the direction perpendicular to the panels. This resolution is a large improvement compared to the values of the Quadra-like TB-PET. The walk-through total-body PET uses its maximum sensitivity (154 cps/kBq) for data acquisition and image reconstruction.

Conclusion

Based on the combination of very good spatial resolution and high sensitivity of the walk-through total-body PET, along with a 2.2 times lower scintillation crystal volume and 1.8 times lower SiPM surface, this scanner can be a very cost-efficient alternative for total-body PET scanners in cases where concomitant CT is not required.
Living donor liver transplantation for a patient with acute liver failure following thyroid storm: a case report
Authors: Nagakawa Kantoku , Soyama Akihiko , Hara Takanobu , Matsushima Hajime , Imamura Hajime , Tanaka Takayuki , Morita Michi , Kuba Sakaya , Adachi Tomohiko , Hidaka Masaaki , Miyaaki Hisamitsu , Akazawa Satoru , Horie Ichiro , Sekino Motohiro , Hara Tetsuya , Okano Shinji , Nakao Kazuhiko , Eguchi Susumu 
Published: December 2023

Abstract
Background
Thyroid storm can be complicated by liver dysfunction, which may occasionally progress to acute liver failure. We herein report a case of acute liver failure following thyroid storm that was treated with living donor liver transplantation after resuscitation from cardiopulmonary arrest.

Case report
The patient was a woman in her 40 s who had been diagnosed with an abnormal thyroid function. She suffered from fatigue and vomiting, and was found to have consciousness disorder, a fever, and tachycardia with a neck mass. She was diagnosed with thyroid storm and was referred to our hospital. After arrival, she went into cardiopulmonary arrest and veno-arterial extracorporeal membrane oxygenation was initiated. In addition to treatment for thyroid storm with antithyroid drugs, steroids, and plasma exchange, extracorporeal life support was required for 5 days. However, despite improvements in her thyroid function, her liver function deteriorated. We planned living donor liver transplantation for acute liver failure after ensuring the recovery and control of the thyroid function following total thyroidectomy. The donor was her husband who donated the right lobe of his liver. Although she experienced acute cellular rejection after surgery, and other complications—including intra-abdominal hemorrhaging and ischemic changes in the intestine—her liver function and general condition gradually improved. One year after living donor liver transplantation, the patient was in a good condition with a normal liver function.

Conclusions
To our knowledge, this is the first report of living donor liver transplantation in a patient with acute liver failure following thyroid storm. Liver transplantation should be recognized as an effective treatment for acute liver failure following thyroid storm.
A case of ductal carcinoma in situ (DCIS) with markedly elevated CA15-3 levels requiring 2 years of diagnosis
Authors: Fujimoto Mutsumi , Kobayashi Yoshie , Kuraoka Kazuya , Yoshiyama Tomoyuki , Shigematu Hideo 
Published: December 2023

Abstract
Background
CA15-3 is often elevated in breast cancer recurrence and rarely in ductal carcinoma in situ (DCIS). We report a case of DCIS with elevated CA15-3 levels, which was diagnosed after over 2 years of follow-up.

Case presentation
A 74-year-old woman presented with a left-sided breast mass and pain. Redness, swelling, and induration were observed in the left breast. Ultrasonography revealed a non-mass lesion in the left 3 o'clock position, skin thickening, and axillary lymphadenopathy. Serum CA15-3 levels were markedly high at 640 U/mL, suggesting inflammatory breast cancer. However, biopsies showed no malignancy. We diagnosed chronic mastitis with elevated CA15-3 levels and followed up with magnetic resonance imaging and a biopsy, as needed. Finally, DCIS was diagnosed 27 months after the first visit. She underwent a left mastectomy and a sentinel lymph node biopsy; DCIS had spread 6.5 cm and was immunohistochemically positive for CA15-3. No metastasis was found in the lymph nodes, but incidental Hodgkin lymphoma was observed. Postoperative normalization of CA15-3 levels indicated that she had DCIS with elevated CA15-3 levels. The patient underwent chemotherapy for Hodgkin lymphoma postoperatively, and there was no evidence of recurrence 1 year after surgery.

Conclusion
High CA15-3 levels can also be observed in DCIS, indicating that CA15-3 should not be used solely in breast cancer staging.
Reversible median nerve neuropathy and local muscle irritation resulting from blind removal attempts of etonogestrel contraceptive implant: a case report
Authors: Fungtammasan Siraphat , Sinthuchai Natchanika , Pataradool Kawee , Jaisamrarn Unnop , Santibenchakul Somsook 
Published: December 2023

AbstractNexplanon is an etonogestrel contraceptive implant that comes with an applicator, making it easier to insert and remove. Complications related to insertion and removal procedures, such as neural-vascular injuries, are rare. We describe a case of reversible median nerve neuropathy and local muscle irritation resulting from blind removal attempts of an iatrogenically migrated implant. The patient presented with an unusual pain at the surgical site along with abnormal sensations and numbness in her left hand that worsened after blind attempts to remove the implant. Radiographs revealed that the rod was 3 cm from her insertion scar and deeply embedded in her left arm. The patient then underwent left arm exploration and implant removal under fluoroscopic guidance by an orthopedic surgeon. The rod was placed intramuscularly, adjacent to the median nerve under the basilic vein. The abnormal sensations and numbness in her left hand could be attributed to median nerve involvement, while the atypical pain at the surgical site could be a result of local irritation from the intramuscularly migrated implant from attempts at removal. The symptoms gradually resolved after surgery. This indicates that patients with impalpable contraceptive implants should be referred for implant removal by specialists familiar with the procedure to prevent further deterioration of adjacent structures from iatrogenic implant migration.
Effect of castration timing and weaning strategy on the taxonomic and functional profile of ruminal bacteria and archaea of beef calves
Authors: Diaz Gerardo R. , Gaire Tara N. , Ferm Peter , Case Lacey , Caixeta Luciano S. , Goldsmith Timothy J. , Armstrong Joe , Noyes Noelle R. 
Published: December 2023

Abstract
Background
Beef cattle experience several management challenges across their lifecycle. Castration and weaning, two major interventions in the early life of beef cattle, can have a substantial impact on animal performance. Despite the key role of the rumen microbiome on productive traits of beef cattle, the effect of castration timing and weaning strategy on this microbial community has not been formally described. We assessed the effect of four castration time windows (at birth, turnout, pre-weaning and weaning) and two weaning strategies (fence-line and truck transportation) on the rumen microbiome in a randomized controlled study with 32 male calves across 3 collection days (i.e., time points). Ruminal fluid samples were submitted to shotgun metagenomic sequencing and changes in the taxonomic (microbiota) and functional profile (metagenome) of the rumen microbiome were described.

Results
Using a comprehensive yet stringent taxonomic classification approach, we identified 10,238 unique taxa classified under 40 bacterial and 7 archaeal phyla across all samples. Castration timing had a limited long-term impact on the rumen microbiota and was not associated with changes in alpha and beta diversity. The interaction of collection day and weaning strategy was associated with changes in the rumen microbiota, which experienced a significant decrease in alpha diversity and shifts in beta diversity within 48 h post-weaning, especially in calves abruptly weaned by truck transportation. Calves weaned using a fence-line weaning strategy had lower relative abundance of Bacteroides, Lachnospira, Fibrobacter and Ruminococcus genera compared to calves weaned by truck transportation. Some genes involved in the hydrogenotrophic methanogenesis pathway (fwdB and fwdF) had higher relative abundance in fence-line-weaned calves post-weaning. The antimicrobial resistance gene tetW consistently represented more than 50% of the resistome across time, weaning and castration groups, without significant changes in relative abundance.

Conclusions
Within the context of this study, castration timing had limited long-term effects on the rumen microbiota, while weaning strategy had short-term effects on the rumen microbiota and methane-associated metagenome, but not on the rumen resistome.
Relationship of sagittal thoracic postural and inlet parameters with nontraumatic neck pain: a systematic review and meta-analysis
Authors: Rani Babina , Paul Abhijit 
Published: December 2023

Abstract
Objectives
Neck pain (NP) is associated with substantial disability as well as economic and psychological distress. T1 slope (T1S) and thoracic inlet angle (TIA) reflect cervical sagittal imbalance, which can have clinical/surgical implications. Evidence of the relationship between the sagittal thoracic posture and inlet parameters and pain and functional status is inconclusive. This review aimed to determine whether these parameters differ between NP and pain-free subjects and to critically appraise their correlation with NP measures.

Methods
The review consists of 15 studies that evaluated thoracic postural and/or inlet parameters on adult NP patients, after a comprehensive literature search from EBSCO, PubMed, Scopus, Embase, and Web of Science databases. Statistical heterogeneity, mean pooled difference (MPD), and effect size were calculated to establish a relationship among studies and to assess the correlation of thoracic postural and inlet parameters with NP measures, positional variation, and NP predictors. Sensitivity analysis was performed in case of high between-studies heterogeneity. The risk of bias was assessed using the Newcastle-Ottawa Quality Assessment Scale. Certainty of evidence was graded using GRADE approach.

Results
Only TIA had a significant MPD of 2.12 (0.48, 3.75). The other measures, namely T1S, neck tilt (NT), high thoracic angle, and thoracic kyphosis angle, were not different between NP and asymptomatic subjects. NP population had a 3.14° higher TIA, 4.12° higher NT, and 2.26° lower T1S in lying position (relative to upright). Only thoracic kyphosis and T1S predicted the presence of NP. Very low to low certainty of evidence exists for most of the outcome measures assessed.

Conclusion
Limited evidence is available for the association between the sagittal thoracic postural and inlet parameters in nontraumatic cervical dysfunction. Test-position differences reflect marginally lower T1S, and higher TIA, NT in lying than the upright. The existing evidence is insufficient to prove a minor, if any, association of thoracic posture with NP.
Test-retest reliability of dichotic listening test in younger adults with normal hearing
Authors: Ramachandran Sundaresan , Kumaar Bhuvaneswari , Karupaiah Kamalakannan , Rajan Remitha , Kodilingam Andal , Manoj Akshaya , Prabhu Prashanth 
Published: December 2023

Abstract
Background
Dichotic listening refers to simultaneously stimulating both ears but with two different stimuli. Dichotic listening tasks were used in the audiological test battery to assess auditory processing abilities in children and adults. Studies have reported the dichotic consonant-vowel syllable test’s test-retest reliability in different attentional manipulation conditions. The objectives are to measure the intra- and inter-test reliability of dichotic consonant vowel tests in young, healthy individuals.

Methods
Sixty participants aged 18–28 with normal hearing sensitivity were recruited for the study. To measure the intra- and inter-test reliability, the dichotic consonant-vowel test was conducted within and between days. The single correct and double correct scores were calculated.

Results
The analysis of the study showed good test-retest reliability for the single correct and double correct scores of the dichotic consonant-vowel test based on Cronbach’s alpha values and Friedman’s tests.

Conclusion
This study’s findings indicate that the dichotic test is a stable measure that can be clinically used for evaluation and can be used for research studies.
Radiographic and Clinical Outcomes After Stand-Alone Anterior Lumbar Interbody Fusion for Symptomatic L5-S1 Retrolisthesis
Authors: Cho Steve S. , Farber S. Harrison , DiDomenico Joseph D. , Teng Clare W. , Park Marian T. , Chang Steve W. , Snyder Laura A. , Mirzadeh Zaman , Uribe Juan S. , Turner Jay D. 
Published: December 2023

BACKGROUND AND OBJECTIVES:
Degenerative lumbar spondylolisthesis is associated with significant pain and disability. The literature on the treatment options and clinical outcomes for lumbar anterolisthesis is robust, but very few reports specifically evaluate lumbar retrolisthesis. This study investigated surgical outcomes for symptomatic L5–S1 retrolisthesis treated with stand-alone L5–S1 anterior lumbar interbody fusion (ALIF).

METHODS:
All patients with symptomatic L5–S1 retrolisthesis treated with stand-alone L5–S1 ALIF at a single institution over a 7-year period were identified. Exhaustive nonoperative management had failed for all patients. Patients with previous lumbar fusion were excluded. Preoperative and postoperative radiographic images and patient-reported outcome measures for 20 patients (14 males and 6 females; mean [SD] age, 50.3 [13.7] years) were analyzed.

RESULTS:
The mean (SD) follow-up was 43.0 (23.7) months (range, 12.1-102.5 months). Patients experienced postoperative improvements in L5–S1 retrolisthesis (P = .048), L5–S1 disk height and angle (P < .001), L5 foraminal height (P < .001), L5–S1 lordosis (P < .001), and lumbar lordosis (P = .01). There were no significant changes in spinopelvic parameters. At the most recent follow-up, minimal clinically important differences in Oswestry Disability Index score, 36-Item Short-Form Survey (SF-36), and numerical rating scale score for leg pain were achieved in 11 of 20 (55%), 7 of 14 (50%), and 7 of 13 (54%) patients, respectively. All patients demonstrated fusion with no graft subsidence at up to 32 months. No patient experienced intraoperative complications, was readmitted, or required a subsequent posterior decompression or fusion because of refractory symptoms.

CONCLUSION:
In our cohort, stand-alone L5–S1 ALIF was associated with radiographic and clinical improvement in patients with symptomatic L5–S1 retrolisthesis.