bluuebunny/crossref_metadata_2025_split huggingface dataset:
Glucagon-like Peptide-1 Receptor Pathway Attenuates Platelet Activation in Aspirin-Exacerbated Respiratory Disease
Authors: Foer Dinah , Amin Taneem , Nagai Jun , Tani Yumi , Feng Chunli , Liu Tao , Newcomb Dawn C , Lai Juying , Hayashi Hiroaki , Snyder William E , McGill Alanna , Lin Anabel , Laidlaw Tanya M , Niswender Kevin D , Boyce Joshua A , Cahill Katherine N 
Published: October 2023

Abstract
Platelets are key contributors to allergic asthma and aspirin-exacerbated respiratory disease (AERD), an asthma phenotype involving platelet activation and IL-33–dependent mast cell activation. Human platelets express the glucagon-like peptide-1 receptor (GLP-1R). GLP-1R agonists decrease lung IL-33 release and airway hyperresponsiveness in mouse asthma models. We hypothesized that GLP-1R agonists reduce platelet activation and downstream platelet-mediated airway inflammation in AERD. GLP-1R expression on murine platelets was assessed using flow cytometry. We tested the effect of the GLP-1R agonist liraglutide on lysine-aspirin (Lys-ASA)–induced changes in airway resistance, and platelet-derived mediator release in a murine AERD model. We conducted a prospective cohort study comparing the effect of pretreatment with liraglutide or vehicle on thromboxane receptor agonist-induced in vitro activation of platelets from patients with AERD and nonasthmatic controls. GLP-1R expression was higher on murine platelets than on leukocytes. A single dose of liraglutide inhibited Lys-ASA–induced increases in airway resistance and decreased markers of platelet activation and recruitment to the lung in AERD-like mice. Liraglutide attenuated thromboxane receptor agonist-induced activation as measured by CXCL7 release in plasma from patients with AERD and CD62P expression in platelets from both patients with AERD (n = 31) and nonasthmatic, healthy controls (n = 11). Liraglutide, a Food and Drug Administration–approved GLP-1R agonist for treatment of type 2 diabetes and obesity, attenuates in vivo platelet activation in an AERD murine model and in vitro activation in human platelets in patients with and without AERD. These data advance the GLP-1R axis as a new target for platelet-mediated inflammation warranting further study in asthma.
A Randomized Comparison between Classical Landmark-based and Ultrasound-guided Right Superficial Cervical Plexus Block in Attenuating Postlaparoscopic Shoulder Pain under Subarachnoid Anesthesia
Authors: Saravanan Balachandar , Chandramohan Thiagarajan , Srinivasan Parthasarathy 
Published: October 2023

ABSTRACT

Background:
Postlaparoscopic shoulder pain is believed to be due to phrenic nerve involvement, with an incidence of 35%–80%. Classical landmark-based right superficial cervical plexus block (SCPB) has been utilized to alleviate postlaparoscopic shoulder pain. However, there is no possibility of phrenic nerve blockade with subcutaneously deposited injectate in landmark-based SCPB. Therefore, we hypothesized that the local anesthetic injectate in the sternocleidomastoid-scalene intermuscular fascial plane under ultrasound guidance is paramount in achieving phrenic nerve blockade. The main objective was to evaluate the effect of ultrasound-guided right SCPB in decreasing postlaparoscopic shoulder pain compared to conventional landmark-guided SCPB.

Methods:
In this prospective randomized trial, 79 adult patients reported for laparoscopic surgeries under spinal anesthesia were randomly divided into groups; A and B. Group A patients received intermediate approach to SCPB with 10 ml of 0.5% bupivacaine under ultrasound guidance. Group B patients received SCPB using a classical landmark-based approach. The incidence of intraoperative and postoperative shoulder pain and other adverse effects were noted.

Results:
Intraoperative shoulder pain was significantly less in Group A than in Group B (5% vs. 43.5%, P < 0.001). The postoperative shoulder pain was also significantly reduced in Group A than in Group B (5% vs. 28.2%, P = 0.013). There were no instances of major adverse effects.

Conclusion:
We conclude that the ultrasound-guided injectate in the sternocleidomastoid-scalene intermuscular space deeper to investing layer but superficial to the prevertebral layer of the deep cervical fascia is central to providing superior shoulder pain relief in patients undergoing laparoscopic surgery under spinal anesthesia than the classical landmark-based SCPB.
The role of remote data capture, wearables, and digital biomarkers in decentralized clinical trials
Authors: Chodankar Deepa , Raval Tapan K. , Jeyaraj Jeyaseelan 
Published: October 2023

Abstract
Decentralized clinical trials (DCTs) are gaining momentum in clinical research as these studies can be executed remotely through telemedicine and mobile/local health-care providers. The COVID-19 pandemic has further accelerated advances and adoption in this area. In the past few years, there has been significant development and growth in the use of remote data that are electronically transmitted from a clinical trial (CT) participant, from outside the clinical setting, to a data repository. Such data may include laboratory data, safety data, or outcome measures reported by the participant, the clinician or the observer. Similarly, wearable health monitoring devices are being increasingly used in health-care and CT settings. Digital biomarkers, which can support continuous measurement of physiologic parameters outside the physical confines of the clinical environment, are also creating new and improved opportunities for patient care and biomedical research, enabling remote monitoring and DCTs. There are several benefits to using remote data capture, wearables, and digital biomarkers in clinical health-care research; however, several questions and challenges still need to be addressed. In an effort to understand the adoption of these technologies in DCTs, and the challenges therein, the authors of this workstream conducted an online survey of clinical research stakeholders across India and reviewed 80 responses. The review article summarizes the key findings from this online survey.
Hepatic Abscess in Inflammatory Bowel Disease: A Systematic Scoping Review of an Overlooked Entity
Authors: Alshammary Shadi Abdullah , Boumarah Dhuha Nahar 
Published: October 2023

Background:
Liver abscess is one of the hepatobiliary manifestations of inflammatory bowel disease (IBD) that has been scarcely described in the literature.

Objectives:
To conduct a scoping review to provide a detailed description of the occurrence of hepatic abscess in patients with IBD and summarize the observed clinical features.

Methodology:
Searches were carried out using relevant keywords in Medline (via PubMed) and Web of Science from inception until June 13, 2022. Only articles that reported the occurrence of hepatic abscess in patients with IBD were included.

Results:
Forty-eight publications (40 case reports and 8 case series) were included, representing 73 patients with IBD who were radiologically or intraoperatively diagnosed with hepatic abscess. Patients with Crohn’s disease were more predisposed to developing hepatic abscess than patients with ulcerative colitis (79.5% vs. 20.5%, respectively). Furthermore, pyogenic liver abscess was found to be more prevalent (57.9%) compared with aseptic (38.7%) and amebic (3.2%) abscesses. No clear relation was found between death or prolonged hospital stay in terms of the clinical presentation or management plan, as mortality was reported in different age groups with different managements.

Conclusion:
To date, there is no consensus regarding the appropriate management of hepatic abscess as an extraintestinal manifestation of IBD. However, the condition shares several features with liver abscess diagnosed among the general population.
High Insulin Resistance in Saudi Women with Unexplained Recurrent Pregnancy Loss: A Case–control Study
Authors: Alghamdi Ahlam A. , Alotaibi Amani S. 
Published: October 2023

Background:
Unexplained recurrent pregnancy loss (RPL) accounts for >50% of the patients with RPL. Insulin resistance (IR) is a potential cause of unexplained RPL.

Objectives:
To evaluate the relationship between insulin resistance (IR) and unexplained RPL among Saudi women.

Methods:
This is a single-center, case–control study conducted at a tertiary hospital in the Eastern Province of Saudi Arabia. The study group comprised Saudi women with unexplained RPL, while the control group had Saudi women with at least one live birth and no RPL. Blood samples were taken to determine the fasting glucose (FG) and fasting insulin (FI) levels. Women with diabetes mellitus and polycystic ovarian syndrome were excluded. A homeostatic model assessment of insulin resistance index (HOMA-IR) value ≥3 was considered as IR.

Results:
The study and control groups comprised 43 and 56 women, respectively. Between the groups, there was a significant difference in the mean age (case: 37.9 ± 5.4 years; control: 32.2 ± 5.9 years; P < 0.0001) and the mean BMI (case: 31.5 ± 6.0; control: 26.1 ± 2.8; P < 0.0001). FG level was slightly higher in the control group (90.9 mg/dL vs 88.7 mg/dL; P = 0.068). FI level was significantly higher in the study group (16.33 μU/mL vs. 6.17 μU/mL; P < 0.0001). HOMA-IR of ≥3 was significantly more common in the study group (n = 22; 51.2%) than the control group (4; 7.1%) (P < 0.0001). After adjusting for age and BMI, IR ≥3 was found to be independently associated with unexplained RPL (aOR: 13.2; 95% CI: 3.77–46.36).

Conclusions:
This study showed that Saudi women with unexplained RPL had significantly higher levels of fasting insulin and insulin resistance than those without a history of RPL. Therefore, it is recommended to assess IR in women with RPL.
An Examination of the Attitudes of Teacher Candidates towards Mobile Learning
Authors: Kirbas Abdulkadir , Bulut Mesut 
Published: October 2023

This study aims to ascertain how potential Turkish language and literature and Turkish teacher candidates tend to mobile learning. In this context, it investigates whether there are any notable differences in these aspiring teachers' attitudes toward mobile learning based on elements like gender, age, major field of study, grade level, personal tablet ownership, computer ownership, income level, social media usage, and enrollment in computer courses. A relational survey model, a quantitative research method, is used in this study. 209 females and 65 males who willingly joined the study at a university in Turkey's east comprise its participant pool. The findings reveal that prospective teachers of Turkish language and literature, as well as Turkish language teaching, strongly endorse the statements in the Mobile Learning Attitude Scale. Furthermore, their attitudes towards mobile learning do not exhibit significant variations concerning variables such as gender, major field of study, grade level, personal tablet ownership, possession of a computer, income level, social media usage, and participation in a computer course. Nevertheless, a noteworthy difference is identified in attitudes towards mobile learning across different age groups. The outcomes imply that while substantial distinctions exist among age groups, the attitudes of prospective teachers in the aforementioned fields do not significantly differ in terms of demographic or technological aspects. These results underscore the importance of integrating mobile learning into teaching and learning. Encouraging positive attitudes towards mobile learning and conducting additional research on this subject are strongly recommended.
Pengaruh Edukasi Teknik Relaksasi Napas Dalam Berbasis Audiovisual Terhadap Skala Nyeri Pasien Pasca Bedah Di Ruang Perawatan Bedah Di Salah Satu Rumah Sakit Swasta Di Yogyakarta
Authors: Suryaningsih Yustina , Rina Setyani Fransisca Anjar , Widianti Christina Ririn 
Published: October 2023

Background: surgery can cause acute pain, this is caused because during surgery there is tissue damage that triggers cytokine discharge. Approximately 80% of patients undergoing surgery experience acute postoperative pain. 40% of patients experience moderate and severe pain during the first 24 hours after surgery. Planning related to pain management needs to be well prepared before surgery. One of the efforts that can be done to prevent the impact of postoperative pain is by educating pre-surgery by using pain management videos. By using audio visual media, the patient will more easily understand and perform pain reduction techniques.
Purpose: to determine the effect of preoperative pain management on the postoperative patient pain scale. The research was conducted at one of the private hospitals in Yogyakarta on February 11-March 07, 2021.
Method: Research design using pre experiment posttest only design, Population in this study as many as 41 respondents, sample selection is done with purposive sampling technique. The samples in this study were 30 divided into two groups, namely 15 respondents of the intervention group who were given education on deep breath relaxation techniques using video and 15 respondents of the control group.
Result: data analysis conducted with Mann-Whitney test, obtained the result of p value 0.123 ( p value > 0.05), meaning there is no difference in the pain scale of the intervention group respondents and the control group.
Conclusion: nurses should motivate and do mentoring when the patient applies the deep breath relaxation techniques that have been taught
PENINGKATAN HASIL BELAJAR IPA DENGAN METODE BERMAIN PERAN DI SMP NEGERI 1 TANJUNG MORAWA
Authors: Pakpahan Rotua Chatarina 
Published: October 2023

Penelitian ini adalah meningkatkan hasil belajar IPA dengan penerapan metode pembelajaran bermain peran (role playing) pada siswa Kelas 7-1 SMP Negeri 1 Tanjung Morawa Tahun ajaran 2019/2020. Penelitian ini adalah penelitian tindakan kelas dengan 2 siklus, setiap siklus terdiri 4 kegiatan yaitu perencanaan, tindakan, observasi dan refleksi yang diikuti oleh perencanaan pada siklus berikutnya dengan memanfaatkan hasil refleksi sebelumnya. Rancangan solusi yang dimaksud adalah tindakan berupa metode pembelajaran bermain peran dalam mengajarkan pokok bahasan Tata Surya Kelas 7-1 SMP Negeri 1 Tanjung Morawa sebanyak 31 orang. Temuan penelitian menunjukkan pembelajaran IPA dengan metode pembelajaran bermain peran (role playing)dapat meningkatkan hasil belajar siswa dibuktikan dengan meningkatnya hasil belajar IPA setiap siklus yaitu dari rata-rata 70,52 menjadi rata-rata 80,19. siswa merasa senang belajar IPA dan termotivasi untuk belajar
The spatio-temporal analysis of land use land cover changes in Multan city, Pakistan
Authors: Hashim Muhammad , Rahman Attaur , Qasim Muhammad , Farooq Muhammad Umar , Muneer Shazia , Ahmed Zaheer 
Published: October 2023

This research is focused on evaluating the transformation of land use preferences in Multan City, Pakistan, for 30 years of study from 1993 to 2023. To accommodate the enhancement in population growth within the city, changes in land use patterns are rapid. With the temporal gap of 10 years, four specified years (1993, 2003, 2013, and 2023) are selected as study years. Supervised classification is applied to satellite images from different Landsat satellites for each study year. The analysis results indicate a considerable alteration in the land use priorities of Multan city over the study period. The expansion in the built-up area is substantial and increased from 9% in 1993 to 32% in 2023. This suggests urbanisation and infrastructure advancement in the city. Agricultural land has decreased significantly, dropping from 76% in 1993 to 66% in 2023. This reduction is attributed to urban expansion encroaching upon agricultural areas as the city grows. The area covered by water bodies has experienced a significant decline, decreasing from 4% of the total area in 1993 to only 1% in 2023. The research highlights the importance of monitoring these changes to ensure sustainable urban development.
UPAYA MILITER AZERBAIJAN DALAM MEMPERTAHANKAN PROVINSI NAGORNO KARABKH 2020
Authors: Linsani Rahmatul , Riyanto Sugeng 
Published: October 2023

This paper refers to the phenomenon of conflict that occurred in 2020 in the Caucasus region. Where this conflict occurred between two countries, namely Azerbaijan and Armenia, which fought over a territory of Nagorno-Karabakh province. The war, which lasted for 40 days or approximately six weeks, was a concern for many parties. Every effort has been made to resolve this conflict both negotiation and mediation. This research uses qualitative methods that will make literature studies in helping to provide maximum results in this research. This research focuses more on Azerbaijan's reasons why it prefers to take on the policy of confrontation in the resolution of the 2020 conflict. Using John Lovel's strategy, the policy adopted by Azerbaijan is the right strategy taking into account its capabilities and the strategy of the opposing country. This research is expected to help international relations studies in providing references and becoming reference material in research in the same region.
Strategi Bauran Pemasaran Dalam Meningkatkan Omzet Penjualan pada Cafe Jolly Coffee Surabaya
Authors: Sari Dwi Retno Anom , Prabowo Budi 
Published: October 2023

The research conducted took the object of research at Cafe Jolly Coffee Surabaya. Being one of the cafes in Surabaya City which has a strategic location in the middle of many existing cafes. The purpose of the research conducted was to find out and analyze how the marketing mix strategy carried out by Cafe Jolly Coffee Surabaya to increase sales turnover. Using descriptive qualitative research methods using SWOT analysis as the research method. Researchers collect data through interviews, observations, and documentation related to the 7P marketing mix which includes product, price, promotion, place, people, process, physical appearance. Jolly Coffee Surabaya has a score of internal factors, namely strengths of 3.02 and weaknesses having a score of 0.34, while from external factors it has an opportunity score of 2.48 and a threat score of 0.62 through IFAS and EFAS analysis. Next, Jolly Coffee Surabaya is in Quadrant I (one) which supports an aggressive strategy to take advantage of existing opportunities by using its strengths. For the IE matrix, the results show that the business company is in Quadrant I (one) position, namely Growth Oriented Strategy in order to increase sales turnover at Cafe Jolly Coffee Surabaya.
Keywords: 7P Marketing mix, SWOT Analysis, Sales Turnover
From Hinduism to Pantheism: An Existentialist Study of Hermann Hesse's Siddhartha
Authors: Ashraf Muhammad Adeel 
Published: October 2023

Siddhartha is a novel about the long journey of an existentially frustrated individual in search of ultimate reality and meaning of existence. The protagonist Siddhartha, a Hindu Brahman is inquisitive in nature and never satisfied with the religious, ontological and philosophical teachings of Brahmans. There are similarities between Siddhartha’s journey from Hinduism to Nirvana and Jacques Lacan’s journey from “symbolic order” to “The Real”. (Lundell) The objective of both Lacan and Siddhartha is to discover the real essence of human life. Siddhartha called it nirvana while Lacan called it The Real. Siddhartha’s journey is existential because he starts his journey by rejecting the social, religious and cultural norms and beliefs of his society. He rejects the teachings of Hinduism and Brahmanism and follows his subjective and authentic understanding in search of reality. In existentialism the individual free will is more important than the societal norms and ideologies. (J. P. Sartre) No meaning is beyond the existing subjective understanding of a free individual as is most briefly explained by famous Sartrean slogan; “existence precedes essence” (J.-P. Sartre). The journey of Lacan is also existential because he was an atheist and went in search of reality with no essentialist beliefs and relied on his own subjective understanding and freewill. This essay is aimed at an explanation and exploration of Siddhartha’s experiences in the novel in the light of ideas of Jacques Lacan and Jean-Paul Sartre. Moreover, the objective is to draw an easily comprehensible line between the real human existence and it’s political, discursive, ideological, “hyperreal” and false representations. (Baudrillard)
The Implication of Gender on Artism: a Review
Authors: Ndewo Larry 
Published: October 2023

Purpose: The Agĩkũyũ people of Kenya are one of the largest people groups in Kenya. However, systematic repression of Gĩkũyũ culture led to many traditional elements being forgotten, put aside, if not lost completely. The overall objective of this study was to assess the thematic concerns addressed by Gikuyu secular popular artists on feminist and gender concern.
Methodology: The paper used a desk study review methodology where relevant empirical literature was reviewed to identify main themes and to extract knowledge gaps.
Findings: This study concluded that contemporary popular Gikuyu secular artists appropriate the language used in Gikuyu folklore to build their ideas on issues affecting women and men in society. So the linguistic styles of various epochs of literary traditions have proved to be valuable. The contextual analysis of various song-texts earmarked in this study indicates that literature is not only important as a form of entertainment but it is used for purging unpleasant feelings that come from starred relationship between men and women in love relationship, thus prompting of use of images that affect both genders..
Unique Contribution to Theory and Practice: This study limited itself to three artists and a sample of eighteen songs in exploration of images of women emanating from gender relations espoused in members of the Gikuyu community of Kenya. There are other premiere and also upcoming artists who sing in Gikuyu language. The researcher recommends research on other artists and their song-texts to help shed more light on other aspects of images of women centering on feminism and gender issues in the contemporary society.
Keywords: Thematic Concerns, Gikuyu, Secular Popular, Artists, Feminist and Gender Concern.