bluuebunny/crossref_metadata_2025_split huggingface dataset:
Activating Tumor‐Selective Liquid Metal Nanomedicine through Galvanic Replacement
Authors: Yan Junjie , Wang Jinqiang , Wang Xinyu , Pan Donghui , Su Chen , Wang Junxia , Wang Mengzhen , Xiong Jianjun , Chen Yu , Wang Lizhen , Xu Yuping , Chen Chongyang , Yang Min , Gu Zhen 
Published: November 2023

AbstractAdvanced chemotherapeutic strategies including prodrug and nanocatalytic medicine have significantly advanced tumor‐selective theranostics, but delicate prodrug screening, tedious synthesis, low degradability/biocompatibility of inorganic components, and unsatisfied reaction activity complicate treatment efficacies. Here, the intrinsic anticancer bioactivity of liquid metal nanodroplets (LMNDs) is explored through galvanic replacement. By utilizing a mechano‐degradable ligand, the resultant size of the aqueous LMND is unexpectedly controlled as small as ≈20 nm (LMND20). It is demonstrated that LMND20 presents excellent tumor penetration and biocompatibility and activates tumor‐selective carrier‐to‐drug conversion, synchronously depleting Cu2+ ions and producing Ga3+ ions through galvanic replacement. Together with abundant generation of reactive oxygen species, multiple anticancer pathways lead to selective apoptosis and anti‐angiogenesis of breast cancer cells. Compared to the preclinical/clinical anticancer drugs of tetrathiomolybdate and Ga(NO3)3, LMND20 administration significantly improves the therapeutic efficacy and survival in a BCap‐37 xenograft mouse model, yet without obvious side effects.
Injectable Supramolecular Hydrogels for In Situ Programming of Car‐T Cells toward Solid Tumor Immunotherapy
Authors: Zhu Chunyan , Ke Lingjie , Ao Xiang , Chen Ying , Cheng Hongwei , Xin Huhu , Xu Xiang , Loh Xian‐Jun , Li Zibiao , Lyu Haiyan , Wang Qi , Zhang Dandan , Ping Yuan , Wu Caisheng , Wu Yun‐Long 
Published: November 2023

AbstractChimeric antigen receptor (CAR)‐T cell immunotherapy is approved in the treatment of hematological malignancies, but remains far from satisfactory in solid tumor treatment due to inadequate intra‐tumor CAR‐T cell infiltration. Herein, an injectable supramolecular hydrogel system, based on self‐assembly between cationic polymer mPEG‐PCL‐PEI (PPP) conjugated with T cell targeting anti‐CD3e f(ab')2 fragment and α‐cyclodextrin (α‐CD), is designed to load plasmid CAR (pCAR) with a T cell specific CD2 promoter, which successfully achieves in situ fabrication and effective accumulation of CAR‐T cells at the tumor site in humanized mice models. More importantly, due to this tumor microenvironment reprogramming, secretion of cellular inflammatory cytokines (interleukin‐2 (IL‐2), tumor necrosis factor‐α (TNF‐α), and interferon‐γ (IFN‐γ)) or tumor killer protein granzyme B is significantly promoted, which reverses the immunosuppressive microenvironment and significantly enhances the intra‐tumor CAR‐T cells and cytotoxic T cells infiltration. To the best of the current knowledge, this is a pioneer report of using injectable supramolecular hydrogel for in situ reprogramming CAR‐T cells, which might be beneficial for solid tumor CAR‐T immunotherapy.
High Performance Self‐Driven Photodetectors Based on MoS2 Schottky Barrier Diode
Authors: Dai Mengde , Wu Qianqian , Wang Chenglin , Liu Xingyu , Zhang Xiumei , Cai Zhengyang , Lin Liangliang , Gu Xiaofeng , Ostrikov Kostya (Ken) , Nan Haiyan , Xiao Shaoqing 
Published: November 2023

AbstractPractical application of two‐dimensional transition metal dichalcogenides (2D TMDCs) involves creating a p‐n diode and a Schottky diode. Unlike p‐n diodes, the research of 2D material‐based Schottky diodes especially in the application field of photodetectors is lacking. Here, a Schottky diode is fabricated by depositing Pt and Ni on the MoS2 to form Schottky and ohmic contacts, respectively. The MoS2 Schottky diode exhibits a rectification ratio of 2.36 × 103 and an ideality factor of 1.12. The electrical characteristics of Ni‐MoS2‐Ni and Pt‐MoS2‐Pt field effect transistors are systematically compared. The Schottky barrier height is estimated to be 94.2 meV by using the thermionic emission theory. The Schottky diode device can exhibit excellent self‐powered photodetection performance in the visible to near‐infrared region (447‐940 nm) due to the strong built‐in electric field originating from the Schottky barrier at the MoS2/Pt interface. The maximum detectivity reaches 2.09 × 1012 Jones with a response time of 52.6 ms under 940 nm laser illumination. Furthermore, the photodetection performance of such a Schottky diode can be further improved by NH3 plasma doping treatment. This work provides not only a simple approach to construct a 2D materials‐based Schottky diode photodetector but also a post treatment technique to further improve the device performance.
Synthesis of Multifunctionalized Thiazolidine‐4‐thiones via [2+2+1] Annulation of Isothiocyanates and CF3‐Imidoyl Sulfoxonium Ylides
Authors: Ding Yuhao , Guo Hailin , Fan Jingwen , Li Zhiyong , Cheng Guolin 
Published: November 2023

Abstract2‐Iminothiazolidin‐4‐one, 5‐ethylidenethiazolidin‐4‐one, and thiazolidine‐4‐thione are all medicinally relevant structures. In this work, a NaSO2CF3‐promoted [2+2+1] cascade annulation reaction of CF3‐imidoyl sulfoxonium ylides and isothiocyanates was reported to synthesize a variety of decorated thiazolidine‐4‐thiones in 35–91% yields with exclusive stereoselectivity. The gram‐scale reaction and further chemoselectiveS‐alkylations demonstrated the synthetic utilities of this transformation.
Spatial Mechano‐Signaling Regulation of GTPases through Non‐Degradative Ubiquitination
Authors: Sewduth Raj N. , Carai Paolo , Ivanisevic Tonci , Zhang Mingzhen , Jang Hyunbum , Lechat Benoit , Van Haver Delphi , Impens Francis , Nussinov Ruth , Jones Elizabeth , Sablina Anna 
Published: November 2023

AbstractBlood flow produces shear stress exerted on the endothelial layer of the vessels. Spatial characterization of the endothelial proteome is required to uncover the mechanisms of endothelial activation by shear stress, as blood flow varies in the vasculature. An integrative ubiquitinome and proteome analysis of shear‐stressed endothelial cells demonstrated that the non‐degradative ubiquitination of several GTPases is regulated by mechano‐signaling. Spatial analysis reveals increased ubiquitination of the small GTPase RAP1 in the descending aorta, a region exposed to laminar shear stress. The ubiquitin ligase WWP2 is identified as a novel regulator of RAP1 ubiquitination during shear stress response. Non‐degradative ubiquitination fine‐tunes the function of GTPases by modifying their interacting network. Specifically, WWP2‐mediated RAP1 ubiquitination at lysine 31 switches the balance from the RAP1/ Talin 1 (TLN1) toward RAP1/ Afadin (AFDN) or RAP1/ RAS Interacting Protein 1 (RASIP1) complex formation, which is essential to suppress shear stress‐induced reactive oxygen species (ROS) production and maintain endothelial barrier integrity. Increased ROS production in endothelial cells in the descending aorta of endothelial‐specificWwp2‐knockout mice leads to increased levels of oxidized lipids and inflammation. These results highlight the importance of the spatially regulated non‐degradative ubiquitination of GTPases in endothelial mechano‐activation.
Angular‐Momentum Transfer Mediated by a Vibronic‐Bound‐State
Authors: Pai Yun‐Yi , Marvinney Claire E. , Pokharel Ganesh , Xing Jie , Li Haoxiang , Li Xun , Chilcote Michael , Brahlek Matthew , Lindsay Lucas , Miao Hu , Sefat Athena S. , Parker David , Wilson Stephen D. , Gardner Jason S. , Liang Liangbo , Lawrie Benjamin J. 
Published: November 2023

AbstractThe notion that phonons can carry pseudo‐angular momentum has many major consequences, including topologically protected phonon chirality, Berry curvature of phonon band structure, and the phonon Hall effect. When a phonon is resonantly coupled to an orbital state split by its crystal field environment, a so‐called vibronic bound state forms. Here, a vibronic bound state is observed in NaYbSe2, a quantum spin liquid candidate. In addition, field and polarization dependent Raman microscopy is used to probe an angular momentum transfer of ΔJz = ±ℏ between phonons and the crystalline electric field mediated by the vibronic bound stat. This angular momentum transfer between electronic and lattice subsystems provides new pathways for selective optical addressability of phononic angular momentum via electronic ancillary states.
A Self‐Assemble Supramolecular Film with Humidity Visualization Enabled by Clusteroluminescence
Authors: Chen Xiang , Hu Chenxi , Wang Yang , Li Ting , Jiang Jie , Huang Jing , Wang Shibo , Dong Weifu , Qiao Jinliang 
Published: November 2023

AbstractClusteroluminescence (CL) has recently gained significant attention due to its unique through‐space interactions associated with a high dependence on the aggregation of subgroups. These distinct features could easily transform the stimuli into visual fluorescence and monitor the fluctuation of the environment but have not received sufficient attention before. In this work, supramolecular films are designed based on the neutralization reaction of anhydride groups and the self‐assembly of dynamic covalent disulfide bonds in NaOH aqueous solution. The self‐assembly of hydrophilic carboxylate chromophores and hydrophobic disulfide‐containing five‐membered rings could be observed by the variation of the aggregation state of carboxylate in CL. Furthermore, the dynamic cross‐linking films obtained with water‐sensitive carboxylate chromophores could alter the aggregation distance stimulated by surrounding water vapor, causing the emission wavelength to change from 534 to 508 nm by varying the relative humidity. This work not only provides an approach to monitor the self‐assembly of clusteroluminogens but also offers new strategies for designing stimuli‐responsive materials that utilize the intrinsic features of CL.
New Template Synthesis of Anomalously Large Capacity Hard Carbon for Na‐ and K‐Ion Batteries
Authors: Igarashi Daisuke , Tanaka Yoko , Kubota Kei , Tatara Ryoichi , Maejima Hayato , Hosaka Tomooki , Komaba Shinichi 
Published: November 2023

AbstractHard carbon (HC) is a promising negative‐electrode material for Na‐ion batteries. HC electrochemically stores Na+ ions, resulting in a non‐stoichiometric chemical composition depending on their nanoscale structure, including the carbon framework, and interstitial pores. Therefore, optimizing these structures for Na storage by altering the synthesis conditions can enhance the capacity of Na‐ion batteries. In this study, HCs using MgO, ZnO, and CaCO3 as nanopore templates are systematically investigated, and the ZnO template is found to be particularly effective. By optimizing the concentration of ZnO embedded in the carbon matrix, utilizing a blend of zinc gluconate, and zinc acetate as starting materials, the optimal ZnO‐template HC demonstrates a reversible capacity of 464 mAh g−1 (corresponding to NaC4.8) with high initial coulombic efficiency of 91.7% and low average potential of 0.18 V versus Na+/Na. Thus, a Na‐ion battery full cell consisting of Na5/6Ni1/3Fe1/6Mn1/6Ti1/3O2 and the optimized ZnO‐template HC demonstrates a remarkable energy density of 312 Wh kg−1, comparable to that of a Li‐ion battery with LiFePO4 and graphite. Moreover, the ZnO‐template HC in a K half‐cell also displays a significant capacity of 381 mAh g−1, that is, KC5.8 where the alkali content is higher than stage‐1 graphite intercalation compounds, LiC6 and KC8.
Understanding Lattice Oxygen Redox Behavior in Lithium‐Rich Manganese‐Based Layered Oxides for Lithium‐Ion and Lithium‐Metal Batteries from Reaction Mechanisms to Regulation Strategies
Authors: Shen Chao , Hu Libin , Duan Qiming , Liu Xiaoyu , Huang Shoushuang , Jiang Yong , Li Wenrong , Zhao Bing , Sun Xueliang , Zhang Jiujun 
Published: November 2023

AbstractLithium‐rich manganese‐based layered oxides (LMLOs) are considered to be one type of the most promising materials for next‐generation cathodes of lithium batteries due to their distinctive anionic redox processes contributing ultrahigh capacity and energy density. Unfortunately, their practical applications are still plagued by several challenges such as undesirable interfacial reactions and structural evolution, as well as voltage hysteresis/recession, in which irreversible anionic redox behavior bears the brunt as the primacy factor. Undoubtedly, a deep understanding of anionic redox reaction mechanisms and irreversible behavior of oxygen species is crucial in order to provide essential guidance for modification strategies for LMLOs. In this paper, the fundamental understanding of intricate anionic redox reaction mechanisms from thermodynamics models to kinetic anionic redox reaction pathways is comprehensively reviewed, and the existing challenges of LMLOs related with irreversible oxygen reaction behavior are analyzed. Furthermore, numerous representative modification strategies for overcoming these challenges, coupled with their underlying mechanisms for regulating anionic redox reversibility are summarized. In addition, the aspects of multi‐scale structural modifications, integration of interdisciplinary technologies, and application in quasi‐/all‐solid‐state battery systems are given some emphasis in terms of further improvement of LMLOs‐based cathode materials for advanced lithium batteries‐based energy storage systems.
Predicting ADHD in alcohol dependence using polygenic risk scores for ADHD
Authors: Patel Kejal H. S. , Walters G. Bragi , Stefánsson Hreinn , Stefánsson Kári , Degenhardt Franziska , Nothen Markus , Van Der Veen Tracey , Demontis Ditte , Borglum Anders , Kristiansen Mark , Bass Nicholas J. , McQuillin Andrew 
Published: November 2023

AbstractAttention deficit hyperactivity disorder (ADHD) is a neurodevelopmental disorder with a high degree of comorbidity, including substance misuse. We aimed to assess whether ADHD polygenic risk scores (PRS) could predict ADHD diagnosis in alcohol dependence (AD). ADHD PRS were generated for 1223 AD subjects with ADHD diagnosis information and 1818 healthy controls. ADHD PRS distributions were compared to evaluate the differences between healthy controls and AD cases with and without ADHD. We found increased ADHD PRS means in the AD cohort with ADHD (mean 0.30, standard deviation (SD) 0.92; p = 3.9 × 10−6); and without ADHD (mean − 0.00, SD 1.00; p = 5.2 × 10−5) compared to the healthy control subjects (mean − 0.17, SD 0.99). The ADHD PRS means differed within the AD group with a higher ADHD PRS mean in those with ADHD, odds ratio (OR) 1.34, confidence interval (CI) 1.10 to 1.65; p = 0.002. This study showed a positive relationship between ADHD PRS and risk of ADHD in individuals with co‐occurring AD indicating that ADHD PRS may have utility in identifying individuals that are at a higher or lower risk of ADHD. Further larger studies need to be conducted to confirm the reliability of the results before ADHD PRS can be considered as a robust biomarker for diagnosis.
Generation of Aromatic N‐Heterocyclic Radicals for Functionalization of Unactivated Alkenes
Authors: Wang Lu , Shi Minxu , Chen Xiaoping , Su Nicholas , Luo Weili , Zhang Xiaheng 
Published: November 2023

AbstractNitrogen‐centered radicals (NCRs) have been widely recognized as versatile synthetic intermediates for the construction of nitrogen containing molecules of high value. As such, there has been a long‐standing interest in the field of organic synthesis to develop novel nitrogen‐based radicals and explore their inherent reactivity. In this study, we present the generation of aromatic N‐heterocyclic radicals and their application in a novel and diverse functionalization of unactivated alkenes. Bench‐stable aromatic N‐heterocyclic pyridinium salts were employed as crucial NCR precursors, which enabled the efficient conversion of various unactivated alkenes into medicinally relevant alkylated N‐heterocyclic amines. This approach offers an unexplored retrosynthetic disconnection for the synthesis of related molecules that commonly possess therapeutic value. Furthermore, this platform can be extended to the synthesis of densely functionalized heterocyclic amines by utilizing disulfides and diethyl bromomalonate as radical quenchers. Mechanistic investigations indicate an energy transfer (EnT) pathway involving the formation of a transient aromatic N‐heterocyclic radical, radical addition to unactivated alkenes, and subsequent generation of the amination product through either hydrogen atom transfer (HAT) or radical addition processes.
Dual‐Catalysed Intermolecular Reductive Coupling of Dienes and Ketones**
Authors: Mayerhofer Victor J. , Lippolis Martina , Teskey Christopher J. 
Published: November 2023

AbstractWe report a mild, catalytic method for the intermolecular reductive coupling of feedstock dienes and styrenes with ketones. Our conditions allow concomitant formation of a cobalt hydride species and single‐electron reduction of ketones. Subsequent selective hydrogen‐atom transfer from the cobalt hydride generates an allylic radical which can selectively couple with the persistent radical‐anion of the ketone. This radical‐radical coupling negates unfavourable steric interactions of ionic pathways and avoids the unstable alkoxy radical of previous radical olefin‐carbonyl couplings, which were limited, as a result, to aldehydes. Applications of this novel and straightforward approach include the efficient synthesis of drug molecules, key intermediates in drug synthesis and site‐selective late‐stage functionalisation.
Synthesis of ionic liquid modified 1‐D nanomaterial and its strategical distribution into the biodegradable binary polymer matrix to get reduced electrical percolation threshold and electromagnetic interference shielding effectiveness
Authors: Nath Krishnendu , Ghosh Suman Kumar , Das Palash , Katheria Ankur , Das Narayan Chandra 
Published: November 2023

AbstractIonic liquid is increasingly being used as a chemical modulator of multi‐walled carbon nanotubes (MWCNT). Here, we report the practical method for producing biodegradable electromagnetic interference (EMI) shield films made of thermoplastic polyurethane (TPU), polybutylene adipate‐co‐terephthalate (PBAT), and 1‐(2‐aminoethyl)‐3‐methyl‐1H‐imidazol‐3‐ium modified MWCNT (MIL). The field emission scanning electron microscopy study of cryo‐fractured 50:50 PBAT/TPU blend giving co‐continuous morphology and subsequent polymer EMI shield nanocomposite material had shown the co‐continuous nanofiller distribution. The nanoparticles were chosen to be distributed in the PBAT portion, according to subsequent research employing HRTEM and DMA. The electrical percolation threshold (EPT) is determined to be situated within 1–3 wt% of nanoparticles loading as the remarkable shift in total EMI shielding efficiency from −14.6 dB (for 1 wt%) to −28.6 dB (for 3 wt%) of nanoparticle‐loaded film at 10 GHz (in X‐band region) for a 0.8 mm thick film reveals that the EPT is approximately at 2 wt% of nanoparticle loading. The effective EMI shielding of −37.3 dB was achieved by 10 wt% of MIL loading.
Birth outcomes following in utero co‐exposure to tobacco and marijuana
Authors: Waddell Madison L. , Dickson Samantha A. , Dodge Phoebe A. , Kopkau Haley E. , Nadolski Katherine N. , Zablocki Victoria , Forrestal Kaya M. , Bailey Beth A. 
Published: November 2023

AbstractBackgroundWith recent changes in tobacco and marijuana use patterns, it becomes crucial to understand how the prenatal co‐use of these substances impacts birth outcomes. The goal of this study was to examine the risk of adverse birth outcomes among infants born to women who used tobacco and marijuana concurrently throughout pregnancy compared to infants of women who used tobacco alone.MethodsThis study involved a retrospective chart review of pregnant women identified via self‐report or biochemical testing who used tobacco products alone (N = 71) or tobacco and marijuana simultaneously (N = 127) at any point throughout pregnancy. Differences in birth outcomes between these groups, including APGAR (appearance, pulse, grimace, activity, and respiration) scores, respiratory distress, neonatal intensive care unit admission, intrauterine growth restriction, birth weight, birth length, head circumference, gestational age, and length of hospital stay, were analyzed using linear regression and odds ratio analysis.ResultsThere were no significant differences in outcomes for infants of women who used tobacco and marijuana compared to infants of women who used tobacco alone during pregnancy. Rates of adverse birth outcomes were high among women who used tobacco compared to what would be expected in unexposed pregnancies.ConclusionsTobacco and marijuana co‐use during pregnancy was not associated with an additional risk of adverse birth outcomes compared to tobacco use alone. Women should be educated on potential risks of marijuana, and especially, tobacco use during pregnancy. These results will inform clinical recommendations for pregnant women using tobacco and marijuana, aiming to decrease preventable adverse outcomes for patients and infants.
Determination of carboxylesterase by fluorescence probe to guide detection of carbamate pesticide
Authors: Feng Jingyi , Gong Yue , Yang Shaoxiang , Qiu Guo , Tian Hongyu , Sun Baoguo 
Published: November 2023

AbstractA carboxylesterase fluorescent probe (Probe 1) was developed for determination of carboxylesterase to guide detection of carbamate pesticide. The probe uses benzothiazole as fluorescence group and phenyldimethyl carbamate as recognition group. The solution of the fluorescent probe gradually changes from light blue to dark blue as the concentration of carbamate pesticides increases. The concentration of carbamate pesticides can be quickly calculated according to the colour of the probe solution through Get Color software on a smartphone. It showed that Probe 1 can be used as a rapid detection tool to achieve rapid detection of carbamate pesticides in juice samples without professional personnel and equipment. Furthermore, the probe has been successfully used to detect carbamate pesticides in fruit juice and vegetable juice.
Why do people buy virtual clothes?
Authors: Khelladi Insaf , Lejealle Catherine , Rezaee Vessal Saeedeh , Castellano Sylvaine , Graziano Domenico 
Published: November 2023

AbstractVirtual clothes consumption is part of the digital virtual consumption practices of the global NFT phenomenon and the global digital fashion trend. While cutting‐edge technologies shape customer experience and behavior, research examining how consumers desire, own, and experience these technologies in general, and virtual objects in particular, remains scarce. Adopting the uses and gratifications (U&Gs) theory and building on research related to brand roles and category, the present research aims to unveil the psychological determinants of purchasing NFTs‐virtual clothes. A mixed‐method, two‐stage approach was adopted. First, a qualitative study and a pilot study aimed to capture and understand what motivates people to buy NFTs‐virtual clothes and identify contextualized U&Gs. Second, two original confirmatory studies verified the U&Gs of purchasing virtual clothes and investigated how they differ based on brand category (luxury vs. non‐luxury). The results show that enjoyment, social interactivity, and curiosity are the main predictors of NFTs‐virtual clothes purchases. Consumers mainly seek hedonic, social, and technological gratifications as part of the digital fashion consumption trend. Brand managers must recognize virtual clothing gratifications for effective virtual world positioning. Products should encourage networking, community, and user interaction. Demographics and virtual experience should be considered to understand NFT‐virtual clothes motivations.