bluuebunny/crossref_metadata_2025_split huggingface dataset:
Cardioprotective effects of vaccination in hospitalized patients with COVID-19
Authors: Madrid Julian , Agarwal Prerana , Müller-Peltzer Katharina , Benning Leo , Selig Mischa , Rolauffs Bernd , Diehl Philipp , Kalbhenn Johannes , Trummer Georg , Utzolino Stefan , Wengenmayer Tobias , Busch Hans-Jörg , Stolz Daiana , Rieg Siegbert , Panning Marcus , Bamberg Fabian , Schlett Christopher L. , Askani Esther 
Published: February 2024

Abstract
Background
COVID-19 vaccination has been shown to prevent and reduce the severity of COVID-19 disease.
Aim
The aim of this study was to explore the cardioprotective effect of COVID-19 vaccination in hospitalized COVID-19 patients.
Methods
In this retrospective, single-center cohort study, we included hospitalized COVID-19 patients with confirmed vaccination status from July 2021 to February 2022. We assessed outcomes such as acute cardiac events and cardiac biomarker levels through clinical and laboratory data.
Results
Our analysis covered 167 patients (69% male, mean age 58 years, 42% being fully vaccinated). After adjustment for confounders, vaccinated hospitalized COVID-19 patients displayed a reduced relative risk for acute cardiac events (RR: 0.33, 95% CI [0.07; 0.75]) and showed diminished troponin T levels (Cohen’s d: -0.52, 95% CI [-1.01; -0.14]), compared to their non-vaccinated peers. Type 2 diabetes (OR: 2.99, 95% CI [1.22; 7.35]) and existing cardiac diseases (OR: 4.31, 95% CI [1.83; 10.74]) were identified as significant risk factors for the emergence of acute cardiac events.
Conclusion
Our findings suggest that COVID-19 vaccination may confer both direct and indirect cardioprotective effects in hospitalized COVID-19 patients.
Radiographic Evaluation of Tuberculosis: a retrospective study among patients in Al- Mouwasat hospital in Damascus
Authors: Al-moalem Mohamad , Al-askar Abdulaziz , Mahmod Jan , Khattab Khalid 
Published: February 2024

Abstract
Background
Tuberculosis (TB) presents a significant global health challenge, affecting both pulmonary and extrapulmonary sites and yielding diverse radiological manifestations. These manifestations, ranging from subtle parenchymal changes to overt abnormalities, include features such as infiltrates, nodules, cavitations, and pleural effusion, often reflecting disease stage, immune status, and anatomical site involvement. Understanding these manifestations is crucial for accurate diagnosis and timely intervention, with radiographic imaging techniques such as chest X-rays and CT scans playing pivotal roles in evaluating TB, alongside advancements in technology enhancing detection and characterization of TB-related abnormalities.
Methods
A retrospective cross-sectional study was conducted utilizing patient records and imaging data collected from 2020 to 2023. Inclusion criteria comprised patients diagnosed with tuberculosis (TB) during this period. Ethical approval was obtained from the institutional review board or ethics committee, ensuring patient confidentiality and data anonymization. Informed consent was not required due to the retrospective nature of the study. Statistical analysis was performed using SPSS version 26.0, computing descriptive statistics including frequencies, percentages, means, and standard deviations.
Results
Our study found a 46–54% male-to-female ratio. Tuberculin skin test positivity was 90%, with 85% showing fever elevation. Upper lobe involvement was seen in 75% of cases, with cavitations present in 3% (chest radiograph) and 22% (CT scan). Pleural effusion occurred in 30% (chest radiograph) and 76% (CT scan), with a density exceeding 20 Hounsfield units in 72%. Bronchial wall thickening was noted in 42% (chest radiograph) and 85% (CT scan). Tree-in-bud appearance was observed in 68% (chest radiograph) and 82% (CT scan). Initial upper lobe involvement with tuberculosis was found in 92% of cases. Hilar lymphadenopathy was present in 69% (chest radiograph) and 88% (CT scan), with lymph nodes measuring 15–20 mm most common at 63%. High-density nodes were seen in 81% and peripheral enhancement in 82% of cases. Lymph nodes in the right hilum were most prevalent at 90%. Segmental consolidation was highest at 85%, with heterogeneous density on CT scan observed in 63% of cases. Thick-walled cavities were seen in 69%, and centrilobular nodules (1–3 mm diameter) were observed in 92%. High-resolution CT scan demonstrated 90% accuracy in diagnosing tuberculosis.
Conclusions
Early diagnosis of tuberculosis (TB) is crucial to prevent adverse outcomes. Radiological diagnostic methods play a vital role in identifying TB and its manifestations. This study explores key radiographic signs of primary and post-primary TB, along with their complications. Additionally, it evaluates the accuracy of radiographic imaging in TB diagnosis.
Formulation and Evaluation of Hydrogel Matrix Tablets of Terazosin Hydrochloride
Authors: DEEPTHI BACHALA , kamere kishore , G.Vijaykumar  
Published: February 2024

Abstract
The aim of present investigation was formulation and development of Terazosin HCl Sustained Release Matrix Tablets. Study started from the preformulation study of the drug. Drug having good solubility in both dissolution mediums. The flow of API is low so directly compressible excipient used for tablet preparation. While studying IR spectrum, we can conclude that there is no interaction between drug and other excipients. Initially feasibility trials were taken using HPMC K4M and K100M. Tablets were found acceptable in physical parameters evaluation. During drug release evaluation amount of HPMC K4M increases the drug release for long period of time. In contrast less amount of HPMC K100M helps in drug release. So role of polymer concentration is very important in this formulation. Based on that F3 batch found satisfactory and considering for further factorial screening. 32 factorial design applied by taking HPMC K4M and PVP K-30 as independent factors. Factorial batch P1-P9 prepared by using direct compression method. Physical and chemical evaluation was done for all batches. PVP K-30 and HPMC K4M significantly impact on Drug release and hence the model found significant. Finally the optimized batch P12 taken based on Contour plot and evaluation done. Batch P12 load for stability for 1 month and found stable. Hence the batch P12 was optimized batch.
Development and Validation of a Multispectral and Thermal Sensor System for In-Field Crop Drought Stress Monitoring in Wheat
Authors: Veloo Kesevan , Valencia-Ortiz Milton , Pumphrey Michael , Carter Arron , Sankaran Sindhuja 
Published: February 2024

Water scarcity profoundly affects crop growth in rain-fed regions,
including the Pacific Northwest (PNW) of the USA. While unmanned aerial
vehicles (UAVs) are integral for crop monitoring in breeding programs,
their use is resource-intensive and necessitates pilot presence in the
field. Alternatively, Internet of Things (IoT)-based sensor systems
offer continuous, remote, and real-time monitoring, but their data
integrity requires validation for field applications. This study
developed a Raspberry Pi-based sensor system (AGIcam+) and compared its
efficacy with UAV in discerning crop responses to drought conditions
across various wheat varieties in the PNW region. Multispectral and
thermal data were collected across wheat trials (Winter 2023; Spring
2022, 2023) at crucial growth stages – preheading, heading, and
post-heading – under varied drought stress conditions. Key vegetation
indices and temperature measurements were extracted for a comparative
drought performance analysis. Results indicate significant correlations
between AGIcam+ and UAV data, more pronounced during the heading and
post-heading stages. Pearson’s correlation coefficients for normalized
difference vegetation index (NDVI) and 95th percentile temperature data
ranged from 0.81-0.88 and 0.81-0.95 (P <0.01),
respectively, across all trials during the heading stages. Yield
prediction models using random forest regression analysis from both
systems’ data underscored AGIcam+’s accuracy in yield estimation,
demonstrating performance comparable to UAV, as evidenced in the Spring
2023 trial ( AGIcam+: R =
0.85, RMSE = 796.9 kg/ha; UAV: R
= 0.84, RMSE = 825.0 kg/ha). These findings underscore AGIcam+ as
a resource-efficient crop monitoring alternative, effectively capturing
responses to environmental conditions and facilitating accurate yield
predictions under drought stress.
Capital adequacy ratio, loan deposit ratio, dan non performing loan terhadap return on asset bank umum
Authors: Tanaya Cahya Akbar , Widodo Eko 
Published: February 2024

Penelitian ini bertujuan untuk mengetahui pengaruh antara variabel Capital Adequacy Ratio (X1), Loan Deposit Ratio (X2) dan Non Performing Loan (X3) terhadap Return On Asset (Y) pada Bank Umum Yang Terdaftar di BEI Periode 2019 - 2021. Jenis penelitian ini adalah penelitian kuantitatif yang digunakan untuk menguji hubungan suatu variabel terhadap variabel lainnya. Pemilihan sampel menggunakan metode purposive sampling, jumlah sampel dalam penelitian diperoleh sebanyak 16 laporan keuangan untuk periode selama 3 tahun yaitu 2019-2021 sehingga ditemukan sampel sebanyak 48. Teknik analisis yang digunakan yaitu Uji Analisis Data Panel, Uji Asumsi Klasik, Uji Hipotesis, Koefisien determinasi. Hasil penelitian diperoleh bahwa variabel CAR berpengaruh signifikan secara parsial terhadap ROA. NPL berpengaruh signifikan secara parsial terhadap ROA. Variabel LDR tidak berpengaruh signifikan secara parsial terhadap ROA. Hasil uji F diperoleh bahwa CAR, LDR dan NPL berpengaruh secara simultan dan signifikan terhadap ROA.
Алгоритм управления формированием роя автономных мобильных роботов
Authors: Кызырканов Абзал , Атанов Сабыржан , Алджаварнех Шади , Турсынова Назира , Сейтбатталов Жексен 
Published: February 2024

Одной из важнейших проблем роевой робототехники является координация движения. Здесь необходимо одновременно найти решение нескольких проблем, таких как, избежание столкновений друг с другом или с препятствиями, нахождение оптимального пути достижения цели и т. п. Одним из наиболее распространенных методов решения таких проблем является движение с сохранением определенной геометрической структурой (управление формированием). При правильном управлении формированием, можно получить множество преимуществ, например, сокращение стоимости системы, увеличение надежности и эффективности системы, обеспечив при этом способность к реконфигурации и гибкость структуры системы.
В данной статье предоставлен алгоритм управления формированием роя автономных мобильных роботов. Также в рамках данной работы с помощью программного продукта, написанного на языке программирование Руthon, было смоделировано движение роя с девятью автономными роботами. Предоставлены результаты экспериментального исследования движения этого роя роботов с использованием алгоритма, описанного в данной статье.
Pengembangan Deteksi Suhu Dan Kelembaban Laboratorium Elektronika Menggunakan Wemos Dengan Tampilan Website
Authors: Niam Bahrun , Qirom Qirom , Jaya Rafli 
Published: February 2024

Laboratorium elektronika merupakan tempat untuk praktikum matakuliah mahasiswa elektronika. Pada labratorium ini terdapat komponen-komponen eletkronika yang harus dijaga dari suhu dan kelembaban. Apabila suhu terlalu dingin dan kelembaban terlalu tinggi bisa mengakibatkan terjadinya korosi pada komponen-komponen elektronika, sehingga bisa mengakibatkan kerusakan. Arduino adalah sebuah kit elektronik open source yang dirancang khusus untuk memudahkan setiap orang dalam mengembangkan perangkat elektronik yang dapat berinteraksi dengan bermacam sensor dan pengendali. Sistem deteksi suhu dan kelembaban udara ruang laboratrorium dengan menggunakan software dan hardware. Software yang digunakan adalah Ardiuno, PHP dan database MySql sedangkan hardwarenya yaitu power supply, mikrokontroler D1 Mini, sensor DHT11 . Data suhu dan kelembaban yang di baca oleh sensor DHT11 akan di proses di mirokontroler D1 Mini dan data akan disimpan di MysQl. Data yang tersimpan di database MySql akan ditampilkan di websiter dalam tampilan dashboard. Tapilan website terdiri dari beberapa menu yaitu, login, dashboard, riwayat sensor, pengguna, perangkat sensor dan logout.
Pengaruh Program Pelatihan dan Kompetensi Terhadap Kinerja (Studi pada RSUD Cilacap)
Authors: Supriyati Eko , Budianto Apri , Herman Ferey 
Published: February 2024

Penelitian ini melakuakn sebuah riset penelitian dalam menilai pengaruh pengembangan sumber daya manusia berbasis kompetensi terhadap kualitas pelayanan.
Rumusan masalah yang diajukan dalam penelitian ini yaitu sebagai berikut: 1) Bagaimana pengaruh program pelatihan tehadap kinerja di RSUD Cilacap.2)Bagaimana pengaruh kompetensi terhadap kinerja pegawai. 3)Bagaimana program pelatihan dan kompetensi terhadap kinerja RSUD Cilacap.
Metode penelitian yang digunakan adalah metode kuantitatif deskriptif dengan metode penyebaran kusioner atau angket. Teknik pengumpulan data dalam penelitian ini adalah studi pustaka dan studi lapangan. Sedangkan teknis analisis data yang digunakan penulis dalam penelitian ini yaitu dengan penyebaran kusioner. Dari hasil penelitian diperoleh bahwa: 1) Hasil dari penelitian rogram pelatihan dan kompetensi pada di RSUD Cilacap berpengaruh positif terhadap kinerja dan berpengaruh signifikan, artinya apabila program pelatihan dan kompetensi yang sangat tinggi maka akan berpengaruh terhadap kinerja. Jadi program pelatihan dan kompetensi adalah factor utama dalam meningkatkan kinerja petugas pada RSUD Cilacap akan meningkat pula.
Природне відновлення дубових насаджень Лівобережного Лісостепу після проведення в них лісовідновних рубок
Authors: Ткач В. П. , Румянцев М. Г. , Лук’янець В. А. 
Published: February 2024

Проведено обліки кількості жолудів і сходів дуба звичайного (Quercus robur L.), що утворилися на суцільних зрубах після проведення лісовідновних рубок смугово-поступовим способом у поєднанні із заходами сприяння природному відновленню, у роки з різною інтенсивністю плодоношення дуба. Також подано результати обліків кількості підросту (зокрема дуба) та його таксаційні показники. Виявлено, що успішність природного відновлення за шкалою УкрНДІЛГА на зрубах, утворених після проведення лісовідновних рубок в ослаблених порослевих дубових деревостанах, після років середнього, доброго та дуже доброго урожаїв жолудів (бал плодоношення 3–5) відповідала категорії «добре». Успішність природного відновлення на зрубі після року низького врожаю (бал плодоношення 2), де додатково було проведено підсівання жолудів у місцях відсутності сходів дуба, відповідала категорії «задовільне», а на зрубі після року дуже низького (бал плодоношення 1) і низького врожаю без підсівання жолудів – «недостатнє». Запропоновано заходи щодо забезпечення успішного природного відновлення дубових лісів насіннєвим шляхом.
PENGGUNAAN METODE CERAMAH TERHADAP MINAT BELAJAR SISWA PADA MATA PELAJARAN PENDIDIKAN AGAMA ISLAM
Authors: Yanti Yuriska Eka , Aprianif Aprianif 
Published: February 2024

This study aims to find out how influential the use of lecture method is on students learning interest in Islamic education subjects for class IX SMPN 2 Kelapa Dua, Tangerang Regency. This research uses quantitative research with one independent variable and one dependent variable. The independent variable is the lecture method while the dependent variable is the studentâ€™s interest in learning. The population of the study was grade IX students at SMPN 2 Kelapa Dua with a sample of 55 students. Source of data come from teacher and student. Data collection techniques using observation, questionnaires, and documentation. The research instrument validation technique uses validity and reliability tests. The data analysis technique used simple linear regression analysis. Â The tests results using simple linear regression analysis obtained a significance value of 0,000<,005 and t count 4,405>2,006 so it can be concluded that Ha is accepted and Ho is rejected. This means that the lecture method has a significant influence on students interest in learning in the subjects of Islamic religious education class IX at SMPN 2 Kelapa Dua.
Identification and validation of a gap junction protein related signature for predicting the prognosis of renal clear cell carcinoma
Authors: Huang Yongsheng , Guo Wenyi , Zeng Yuan , Wang Xinrong , Fan Bohao , Zhang Ying , Yan Lei , Gu Gangli , Liu Zhao 
Published: February 2024

BackgroundGap junction proteins (GJPs) are a class of channel proteins that are closely related to cell communication and tumor development. The objective of this study was to screen out GJPs related prognostic signatures (GRPS) associated with clear cell renal cell carcinoma (ccRCC).Materials and MethodsGJPs microarray data for ccRCC patients were obtained from The Gene Expression Omnibus (GEO) database, along with RNA sequencing data for tumor and paired normal tissues from The Cancer Genome Atlas (TCGA) database. In the TCGA database, least absolute shrinkage and selection Operator (LASSO) and Cox regression models were used to identify GJPs with independent prognostic effects as GRPS in ccRCC patients. According to the GRPS expression and regression coefficient from the multivariate Cox regression model, the risk score (RS) of each ccRCC patient was calculated, to construct the RS prognostic model to predict survival. Overall survival (OS) and progression-free survival (PFS) analyses; gene pan-cancer analysis; single gene survival analysis; gene joint effect analysis; functional enrichment analysis; tumor microenvironment (TME) analysis; tumor mutational burden (TMB) analysis; and drug sensitivity analysis were used to explore the biological function, mechanism of action and clinical significance of GRPS in ccRCC. Further verification of the genetic signature was performed with data from the GEO database. Finally, the cytofunctional experiments were used to verify the biological significance of GRPS associated GJPs in ccRCC cell lines.ResultsGJA5 and GJB1, which are GRPS markers of ccRCC patients, were identified through LASSO and Cox regression models. Low expression of GJA5 and GJB1 is associated with poor patient prognosis. Patients with high-RS had significantly shorter OS and PFS than patients with low-RS (p&lt; 0.001). The risk of death for individuals with high-RS was 1.695 times greater than that for those with low-RS (HR = 1.695, 95%CI= 1.439-1.996, p&lt; 0.001). Receiver Operating Characteristic (ROC) curve showed the great predictive power of the RS prognostic model for the survival rate of patients. The area under curve (AUC) values for predicting 1-year, 3-year and 5-year survival rates were 0.740, 0.781 and 0.771, respectively. The clinical column chart was also reliable for predicting the survival rate of patients, with AUC values of 0.859, 0.846 and 0.796 for predicting 1-year, 3-year and 5-year survival, respectively. The GRPS was associated with immune cell infiltration, the TME, the TMB, and sensitivity to chemotherapy drugs. Further in vitro experiments showed that knockdown of GJA5 or GJB1 could promote the proliferation, migration and epithelial-mesenchymal transition (EMT) and inhibit apoptosis of ccRCC cells.ConclusionGJA5 and GJB1 could be potential biological markers for predicting survival in patients with ccRCC.
Comparative evaluation of antioxidant activity, total phenolic content, anti-inflammatory, and antibacterial potential of Euphorbia-derived functional products
Authors: Benjamaa Rania , Elbouny Hamza , Errati Hajare , Moujanni Abdelkarim , Kaushik Neha , Gupta Ravi , Ennibi OumKeltoum , Nasser Boubker , Choi Eun Ha , Kaushik Nagendra Kumar , Essamadi Abdelkhalid 
Published: February 2024

This study assessed the medicinal properties of Euphorbia resinifera O. Berg (E. resinifera) and Euphorbia officinarum subsp echinus (Hook.f. and Coss.) Vindt (Euphorbia echinus, known for their pharmaceutical benefits. Extracts from their flowers, stems, propolis, and honey were examined for phenolic content, antioxidant, anti-inflammatory, and antibacterial activities. Total phenolic content (TPC), total flavonoid content (TFC), and total condensed tannin (TCC) were determined using specific methods. Antioxidant potential was assessed through various tests including DPPH, FRAP, ABTS, and Total antioxidant capacity. Anti-inflammatory effects were evaluated using phenol-induced ear edema in rats, while antibacterial activity was measured against Gram-positive (Staphylococcus aureus ATCC 6538) and Gram-negative (E. coli ATCC 10536) bacteria. Among the extracts, the aqueous propolis extract of E. resinifera demonstrated exceptional antioxidant capabilities, with low IC50 values for DPPH (0.07 ± 0.00 mg/mL) and ABTS (0.13 ± 0.00 mg/mL), as well as high TAC (176.72 ± 0.18 mg AA/mg extract) and FRAP (86.45 ± 1.45 mg AA/mg extract) values. Furthermore, the anti-inflammatory effect of E. resinifera propolis extracts surpassed that of indomethacin, yielding edema percentages of 3.92% and 11.33% for the aqueous and ethanolic extracts, respectively. Microbiological results indicated that the aqueous extract of E. resinifera flower exhibited the most potent inhibitory action against S. aureus, with an inhibition zone diameter (IZD) of 21.0 ± 0.00 mm and a minimum inhibitory concentration (MIC) of 3.125 mg/mL. Additionally, only E. resinifera honey displayed the ability to inhibit E. coli growth, with an inhibition zone diameter of 09.30 ± 0.03 mm and a MIC of 0.0433 mg/mL.
Psychedelic substitution: altered substance use patterns following psychedelic use in a global survey
Authors: Glynos Nicolas G. , Aday Jacob S. , Kruger Daniel , Boehnke Kevin F. , Lake Stephanie , Lucas Philippe 
Published: February 2024

IntroductionRecent research suggests that psychedelics may have potential for the treatment of various substance use disorders. However, most studies to date have been limited by small sample sizes and neglecting to include non-North American and European populations.MethodsWe conducted a global, cross-sectional online survey of adults (n = 5,268, 47.2% women) self-reporting past or current psychedelic use and investigated whether psychedelic use was associated with changes in use of other substances.ResultsNearly three-quarters (70.9%; n = 3,737/5,268) reported ceasing or decreasing use of one or more non-psychedelic substances after naturalistic psychedelic use. Among those with previous use, 60.6% (n = 2,634/4,344) decreased alcohol use, 55.7% (n = 1,223/2,197) decreased antidepressant use, and 54.2% (n = 767/1,415) decreased use of cocaine/crack. Over a quarter of the sample indicated that their decrease in substance use persisted for 26 weeks or more following use of a psychedelic. Factors associated with decreased use included a motivation to either decrease one’s substance use or self-treat a medical condition. Importantly, 19.8% of respondents also reported increased or initiated use of one or more other substances after psychedelic use, with illicit opioids (14.7%; n = 86/584) and cannabis (13.3%; n = 540/4,064) having the highest proportions. Factors associated with increased substance use included having a higher income and residing in Canada or the US.DiscussionAlthough limited by cross-sectional study design, this large observational study will help inform future studies aiming to investigate the relationship between substance use patterns and psychedelic use.