bluuebunny/crossref_metadata_2025_split huggingface dataset:
PP/MACAIBA almond composites: Effect of SEBS-MA and EPDMA-MA compatibilizers on the mechanical properties and biodegradation
Authors: Siqueira Danilo Diniz , Luna Carlos Bruno Barreto , Dos Santos Filho Edson Antônio , Araújo Edcleide Maria , Ramos Wellen Renate Maria 
Published: December 2023

There is a need to develop environmentally friendly materials, especially plastics, that minimize environmental pollution. In this sense, polypropylene (PP) composites were produced with 20 wt% of Macaiba almond powder (MA*) and compatibilized with SEBS-MA and EPDM-MA to carry out a biodegradation investigation of these composites. Mechanical properties (impact, tensile), heat deflection temperature (HDT), scanning electron microscopy (SEM), and Fourier transform spectroscopy (FTIR) experiments were performed. These analyses verified that the best plasticization was reached in the composites with 15% of SEBS-MA and EPDM-MA, indicating an interaction between phases. The impact strength and elongation at break of the PP/MA*/EPDM-MA and PP/MA*/SEBS-MA composites increased significantly, suggesting tough behavior. Biodegradation occurred in the soil for 120 days, and both PP/MA*/10EPDM-MA and PP/MA*/15EPDM-MA demonstrated a mass loss of about 4.68% and 4.0%, respectively. Although PP is not biodegradable, the results show that macaíba almond powder can biodegrade in the PP matrix.
Universal-offer HIV testing in primary care: A mixed-methods evaluation of a pilot study
Authors: Wenlock Rhys , Dhillon Syra , Perera Sean , Vera Jaime , Llewellyn Carrie , Dean Gillian 
Published: December 2023

Background Offering HIV tests to all patients undergoing blood tests in primary care has been recommended by the National Institute for Health and Care Excellence (NICE) in the UK since 2016 but has not been fully adopted. We sought to evaluate the acceptability and feasibility of such a service in primary care. Methods A 3-weeks pilot of offering HIV tests to all patients undergoing blood tests was conducted in a general practice in the UK and evaluated using a mixed-methods approach. Whether patients were offered and accepted tests was recorded and any differences by patient’s age and gender assessed. All patients and HCPs offering testing were approached for semi-structured interviews. Results Two-hundred-and-51 patients (mean [range] 57.5 years [18 to 97], 58% female) attended blood test appointments with 117 being offered a HIV test (46.6%). 78.6% ( n = 92) accepted testing with 91 negative results. The proportion of patients offered testing was associated with the HCP offering the test. No associations between the age or gender of the patient and their odds of being offered or accepting a test were observed. Patient semi-structured interviews ( n = 13) revealed a range of previous HIV testing experiences, patients felt the “offer” of a test to be routine and non-judgemental and felt that receiving negative results via SMS was appropriate. Several participants reported not fully considering the implications of a positive result when they accepted the test. Interviews with HCPs ( n = 3) identified no significant service-level barriers. Conclusions Offering HIV tests to patients undergoing blood tests in primary care is feasible and acceptable. The principal barrier to uptake was HCPs not offering testing.
Phytochemical Profiling, Antioxidant, and Antifungal Activities of Ethyl Acetate and Chloroformic Extracts from Three Mentha Species
Authors: Bouali Nouha , Hajlaoui Hafedh , Arraouadi Soumaya , Saeed Mohd , Tasleem Munazzah , Mejdi Snoussi , Kadri Adel 
Published: December 2023

Background Phytopathogenic fungi remain the main infectious agents in plants, causing severe damage to the environment and human health. Thus, to reduce the usage of synthetically derived fungicides and perform agricultural crop production, the search for new control strategies including plant extracts constitutes an eco-friendly and safe alternative. Objectives This study aimed to quantify the phytochemical constituents of the three plant ( Mentha pulegium L., Mentha spicata L., and Mentha longifolia L.) extracts and to screen their phytochemical composition including total phenolic (TPC), flavonoids (TFC) and condensed tannins contents (TCTC), and to evaluate their antioxidant activities. The efficacy of all mint extracts will be investigated against phytopathogenic fungal species. Materials and Methods The three plant extracts were screened to assess their total phenolic, flavonoids, and condensed tannin contents using spectrophotometric assays. The antioxidant activities include 1,1-diphenyl-2-picrylhydrazyl (DPPH), ferric ion reducing antioxidant power (FRAP), and β-carotene assays. The antifungal activities were investigated on phytopathogenic species including Botrytis cinerea, Fusarium culmorum, Fusarium oxysporum, Aspergillus niger, Aspergillus flavus, and Trichoderma sp. Results Quantitative analyses of phytochemical constituents of Mentha genus extracts revealed that both ethyl acetate (EtAc) and chloroformic (Chl) extracts are a rich source of phenols, flavonoids, and condensed tannins. Ethyl acetate extract of M. longifolia (EtAc L) displayed the highest content of phenols (69.9 ± 1.35 mg GAE/g DW) and flavonoids (53.26 ± 2.11 mg CE/g DW), while M. pulegium ethyl acetate extract (EtAc P) has the highest condensed tannins content (2.13 ± 0.4 mg CE/g DW). Moreover, the tested extracts exhibited potent antioxidant activities at low concentrations for EtAc L, followed by M. spicata (EtAc S), and EtAc P (IC50 = 35.76 ± 1.32 µg/mL for scavenging DPPH free radicals; EC50 527.96 ± 5.45 µg/mL for FRAP, and IC50 = 106.3 ± 3.75 µg/mL for β-carotene bleaching test). Finally, all tested extracts were able to inhibit the growth of several phytopathogenic micro-organisms on both agar and broth media. Conclusion The Mentha extracts derived from the three mint species (i.e., L, P, and S) could be used for their antifungal activities to provide sustainable crop pest management.
Symptoms and Prognoses of Patients With Breast Cancer and Malignant Wounds in Palliative Care Units: The Multicenter, Prospective, Observational EASED Study
Authors: Takeda Yuma , Ishiki Hiroto , Oyamada Shunsuke , Otani Hiroyuki , Maeda Isseki , Yamaguchi Takashi , Hamano Jun , Mori Masanori , Morita Tatsuya 
Published: December 2023

Background This study sought to investigate the symptoms and prognoses of patients with breast cancer and malignant wounds in the palliative care unit setting. Methods This study was a sub-group analysis of a multicenter, prospective, observational study. Patients admitted to 23 palliative care units in Japan between January and December 2017 were enrolled. Data of patients with breast cancer were extracted. We compared demographic characteristics, symptoms, and prognoses by breast cancer malignant wound status. The primary outcome was overall survival. Secondary outcomes included Palliative Prognostic Index (PPI) score, malignant wound characteristics, and symptom burden. Results Of 1896 patients, 131 (6.9%) had breast cancer. In this cohort, 44 (33.6%) patients had malignant wounds. Most malignant wounds (88%) were on the back and chest. Malignant wounds were associated with skin redness, erosion, necrosis, or fistula. Symptoms included bleeding, exudate, odor, and pain. Twenty-eight patients (63.6%) needed dressing changes and 14 (31.8%) patients experienced bleeding. None died due to bleeding. In the malignant wounds group, 32 (72.8%) patients had used an opioid dose equivalent to 38 mg of oral morphine daily, compared to 25 mg by 57 (65.5%) patients in the non-malignant wounds group ( P = .26). Median PPI scores at hospital admission were 4.5 vs 6.5 ( P = .08). Median survival was 23 vs 21 days ( P = .48). Conclusions Patients with malignant wounds had a distinct symptom burden profile and tended to use a higher dose of opioids. The effect of malignant wounds on survival was unclear.
Idioms of distress: Feasibility trial findings on reducing somatic symptoms through a community-based, culturally integrated intervention in Somaliland
Authors: Bentley Jacob A , Gutierrez Daniel , Alsubaie Mohammed , Rosencrans Peter , Peconga Emma , Angula Dega , Egeh Momin H , Feeny Norah , Zoellner Lori 
Published: December 2023

Background Somatic complaints play a central role in the posttraumatic psychological symptom presentation among people within many cultural contexts. One theory about the function of somatic symptoms suggests that diffuse bodily complaints serve as idioms of distress. However, few studies have examined the effect of culturally adapted trauma interventions on reducing somatic symptoms specifically implemented in a low-income country. Methods We examined the effects of Islamic Trauma Healing – a brief, group- and mosque-based, lay-led intervention – on somatic symptom reduction in a pre-post feasibility study conducted in Somaliland. Inclusion criteria were DSM-5 trauma exposure and DSM-5 re-experiencing or avoidance. Participants (N = 26; 12 men, 14 women) reported large intervention effects for somatic symptoms ( g = 2.74, SSS-8). Higher pre-intervention somatic symptoms showed moderate to large associations with higher overall PTSD symptoms ( r = .43, P = .03). At post-intervention, somatic symptoms were only significantly associated with higher PTSD avoidance symptoms ( r = .41, P = .04) and lower well-being ( r = -.49, P = .01). No gender effects on total somatic symptom scores were observed. Discussion Results of this feasibility trial bring into focus overlap between mental health symptom reporting and somatic concerns as conceptualized within the context of cultural idioms of distress. Moreover, these findings suggest that diffuse transdiagnostic somatic symptoms could offer opportunity to learn about the intersections among culture, posttraumatic stress, and idioms of distress as mechanisms in global mental health intervention development.
Surgical Treatments and Long-Term Outcomes for Pediatric Patients With Lumbar Spinal Tumors
Authors: Zhang Yue , Chen Wenjun , Cao Shuang , He Shaohui , Wei Haifeng 
Published: December 2023

Study Design Retrospective case‒control study Objectives This study aimed to report the effects of surgical intervention on spinal stability recovery and to assess the long-term outcomes of children and adolescents with lumbar tumors. Methods From January 2016 to June 2021, 42 pediatric patients with lumbar tumors were selected and separated into different groups based on the surgical method used (total en bloc resection (TER) group, n = 21; piecemeal resection (PR) group, n = 21; titanium mesh (TM) group n = 23; artificial vertebrae (AV) group n = 19). The clinicopathological characteristics, treatments and related outcomes were described in detail and compared between groups, with P value ≤.05 indicating statistically significant differences. Results The average follow-up duration was 24.89 months, and the mean age was 14.89 ± 2.41 years. There were no significant differences in the mean operation time, average blood loss, complication rate, or length of hospital stay between the groups. The ODI, VAS and JOA scores at the final follow-up (FF) were elevated after surgery in all groups. The FF local angular drift (LOD) and lumbar angular drift (LUD) were greater in the TM group than in the AV group ( P = .03, P = .001). Conclusions After surgery, pediatric patients with lumbar tumors can obtain satisfactory spinal stability, effective relief of pain symptoms and substantial improvements in neurological function. There was no significant difference in the invasiveness, safety or timeliness between the 2 surgical methods, so TER is recommended due to its low postoperative recurrence rate and good local control. Spinal fusion in the AV group resulted in better spinal stability.
Disparities in Postpartum Depression Among Urban and Rural Mothers in Hadiya Zone Shashogo District Southern Ethiopia Community-Based Comparative Cross-Sectional Study
Authors: Mekuria Kassahun , Beyene Tilahun , Lajore Bereket Aberham , Melkamu Tsegaye , Ejajo Tekle 
Published: December 2023

Introduction Postpartum depression (PPD) is a nonpsychotic depressive state that begins after childbirth. In Ethiopia, there was limited evidence about the prevalence and factors associated with PPD in terms of residence. Objective To assess disparities in PPD among urban and rural mothers in the Shashogo district, Hadiya zone southern Ethiopia 2022. Methods Community-based comparative cross-sectional study design was employed from May 3 to July 3, 2022. A sample size of 556 (185 from urban and 371 from rural) was calculated using a double population proportion approach and mothers in the postpartum period were randomly selected from both urban and rural settings using stratification followed by single stage and the systematic random sampling method. Data were gathered by trained data collectors using an interviewer-administered questionnaire and analyzed using SPSS Version 25. Statistical significance was declared at a P value of < .05 Results One hundred forty-four (26.6%) mothers in the postpartum period with 95%CI [23-30] were depressed, of which 37 (19.8%) with 95% CI [14-26] in urban and 107 (30%) with 95% CI [25-35] found in a rural setting. Unplanned pregnancy, low maternal social support, assisted delivery, no antenatal care (ANC) follow-up, no postnatal care (PNC) follow-up, and low household income were independent predictors of PPD in rural residence whereas unplanned pregnancy, low maternal social support, assisted delivery, and antenatal depression were independent predictor of PPD in urban. Conclusion PPD was found to be high in the study area as compared to national/global burden. Unplanned pregnancy, low maternal social support, and assisted delivery were predictors for both urban and rural. Low income, no ANC, and PNC follow-up were associated with PPD in rural settings only whereas antenatal depression is a predictor of PPD in urban settings.
Opportunity to Perform – Should Simulation-Based Surgical Training be Provided on Demand or on Supply?
Authors: Rölfing Jan Duedal , Sloth Sigurd Beier , Falstie-Jensen Thomas , Mygind-Klavsen Bjarne , Elsøe Rasmus , Jensen Rune Dall 
Published: December 2023

Introduction The aim of the study was to assess the surgical case volume of residents before and after simulation-based training in hip fracture surgery provided on demand versus knee and shoulder arthroscopy provided on supply. Materials and Methods A retrospective analysis of surgical case volume in hip fracture surgery and arthroscopic shoulder and knee procedures 90 days before and after simulation-based training of either procedure. Sixty-nine orthopedic residents voluntarily participating in either simulation-based training. Hip fracture surgery simulation was provided on supply, ie, whenever 1–2 residents applied for the course, while the arthroscopic simulation course was supplied twice yearly. Results Thirty-four residents participated in hip fracture simulation on demand and 35 residents participated in arthroscopic simulation on supply. The surgical case volume of hip fracture osteosynthesis increased from median 2.5 (range: 0–21) to median 11.5 (1–17) from 90 days before to the 90 days after the simulation-based training on demand. The median difference was 6.5 procedures (p < 0.0003). On the contrary, the surgical case volume in shoulder and knee arthroscopy was low both before and after the simulation on supply, ie, median 2 (0–22) before and median 1 (0–31) after. The median difference was 0 (p = 0.21). Conclusions Simulation on demand was associated with increased opportunities to perform in the clinical environment after the simulation-based training compared with simulation on supply. Simulation-based training should be aligned with the clinical rotation of the residents. Simulation on demand instead of supply on fixed dates may overcome this organizational issue of aligning training with the opportunity to perform.
Sonographers and Vascular Technologists Offer Potential Solutions to Promote the Health and Well-being of Their Workforce
Authors: Parga Madeline R. , Evans Kevin D. , Sommerich Carolyn M. , Roll Shawn C. 
Published: December 2023

Objective: Work-related injuries have a major effect on worker health and well-being. This is particularly true in sonography, where work-related musculoskeletal disorders (WRMSDs) are common. In response to the current challenge of understanding strategy implementation across social and organizational dimensions, this research captured sonographers’, echocardiographers’, and vascular technologists’ perceptions of critical administrative, organizational, and general health and training challenges, and potential solutions for improving worker health and well-being. Materials and Methods: A survey invitation was sent to the WRMSD Grand Challenge longitudinal study registry participants. Open-ended questions on the online questionnaire allowed respondents to share comments, ideas, or potential solutions to improve worker health and well-being regarding the administrative and organizational environment or through training and general health interventions. There were 377 free-text responses that were qualitatively analyzed using a grounded theory approach to generate overarching themes and identify emerging theory, supported by initial coding, focused coding, and reflexive memoing. A member check was conducted by interviewing four participants to refine and confirm the findings. Results: Five themes were identified: “Limits and Guidelines,” “Injury Education,” “Ergonomics Training Constraints,” “Resources and Equipment,” and “Individual Habits.” Participant suggestions within these themes were categorized and mapped onto a sociotechnical systems model that was developed previously to study the healthcare system(s) in which sonography users work. This conceptual mapping revealed how these solutions were situated to impact different levels of the work environment. The themes and mapping supported an emerging grounded theory: Risk Reduction Relies on Proper Employee Representation. Conclusion: These qualitative findings align with contemporary guidelines and recommendations for mitigating injuries in sonographers, illuminating challenges and solutions targeting levels of influence beyond the staff sonographers’ scope. The need for representation of sonographers at higher-level administrative levels has not heretofore been addressed by WRMSD guidelines.
Associations of combined phenotypic ageing and genetic risk with incidence of chronic respiratory diseases in the UK Biobank: a prospective cohort study
Authors: Wang Ting , Duan Weiwei , Jia Xinying , Huang Xinmei , Liu Yi , Meng Fanqing , Ni Chunhui 
Published: December 2023

BackgroundAccelerated biological ageing has been associated with an increased risk of several chronic respiratory diseases. However, the associations between phenotypic age, a new biological age indicator based on clinical chemistry biomarkers, and common chronic respiratory diseases have not been evaluated.MethodsWe analysed data from 308 592 participants at baseline in the UK Biobank. The phenotypic age was calculated from chronological age and nine clinical chemistry biomarkers, including albumin, alkaline phosphatase, creatinine, glucose, C-reactive protein, lymphocyte percent, mean cell volume, red cell distribution width and white blood cell count. Furthermore, phenotypic age acceleration (PhenoAgeAccel) was calculated by regressing phenotypic age on chronological age. The associations of PhenoAgeAccel with incident common chronic respiratory diseases and cross-sectional lung function were investigated. Moreover, we constructed polygenic risk scores and evaluated whether PhenoAgeAccel modified the effect of genetic susceptibility on chronic respiratory diseases and lung function.ResultsThe results showed significant associations of PhenoAgeAccel with increased risk of idiopathic pulmonary fibrosis (IPF) (hazard ratio (HR) 1.52, 95% CI 1.45–1.59), COPD (HR 1.54, 95% CI 1.51–1.57) and asthma (HR 1.18, 95% CI 1.15–1.20) per 5-year increase and decreased lung function. There was an additive interaction between PhenoAgeAccel and the genetic risk for IPF and COPD. Participants with high genetic risk and who were biologically older had the highest risk of incident IPF (HR 5.24, 95% CI 3.91–7.02), COPD (HR 2.99, 95% CI 2.66–3.36) and asthma (HR 2.07, 95% CI 1.86–2.31). Mediation analysis indicated that PhenoAgeAccel could mediate 10∼20% of the associations between smoking and chronic respiratory diseases, while ∼10% of the associations between particulate matter with aerodynamic diameter <2.5 µm and the disorders were mediated by PhenoAgeAccel.ConclusionPhenoAgeAccel was significantly associated with incident risk of common chronic respiratory diseases and decreased lung function and could serve as a novel clinical biomarker.
Children with severe asthma have substantial structural airway changes on computed tomography
Authors: van den Bosch Wytse B. , Lv Qianting , Andrinopoulou Eleni-Rosalina , Pijnenburg Mariëlle W.H. , Ciet Pierluigi , Janssens Hettie M. , Tiddens Harm A.W.M. 
Published: December 2023

BackgroundIn adults with severe asthma (SA) bronchial wall thickening, bronchiectasis and low attenuation regions (LAR) have been described on chest computed tomography (CT) scans. The extent to which these structural abnormalities are present in children with SA is largely unknown. Our aim was to study the presence and extent of airway abnormalities on chest CT of children with SA.Methods161 inspiratory and expiratory CT scans, either spirometer-controlled or technician-controlled, obtained in 131 children with SA (mean±SDage 11.0±3.8 years) were collected retrospectively. Inspiratory scans were analysed manually using a semi-quantitative score and automatically using LungQ (v2.1.0.1; Thirona B.V., Nijmegen, the Netherlands). LungQ segments the bronchial tree, identifies the generation for each bronchus–artery (BA) pair and measures the following BA dimensions: outer bronchial wall diameter (Bout), adjacent artery diameter (A) and bronchial wall thickness (Bwt). Bronchiectasis was defined as Bout/A ≥1.1, bronchial wall thickening as Bwt/A ≥0.14. LAR, reflecting small airways disease (SAD), was measured automatically on inspiratory and expiratory scans and manually on expiratory scans. Functional SAD was defined as FEF25–75and/or FEF75z-scores <−1.645. Results are shown as median and interquartile range.ResultsBronchiectasis was present on 95.8% and bronchial wall thickening on all CTs using the automated method. Bronchiectasis was present on 28% and bronchial wall thickening on 88.8% of the CTs using the manual semi-quantitative analysis. The percentage of BA pairs defined as bronchiectasis was 24.62% (12.7–39.3%) and bronchial wall thickening was 41.7% (24.0–79.8%) per CT using the automated method. LAR was observed on all CTs using the automatic analysis and on 82.9% using the manual semi-quantitative analysis. Patients with LAR or functional SAD had more thickened bronchi than patients without.ConclusionDespite a large discrepancy between the automated and the manual semi-quantitative analysis, bronchiectasis and bronchial wall thickening are present on most CT scans of children with SA. SAD is related to bronchial wall thickening.