bluuebunny/crossref_metadata_2025_split huggingface dataset:
Exploration of Pharmacological Mechanisms of Dapagliflozin against Type
2 Diabetes Mellitus through PI3K-Akt Signaling Pathway based on
Network Pharmacology Analysis and Deep Learning Technology
Authors: Wu Jie , Chen Yufan , Shi Shuai , Liu Junru , Zhang Fen , Li Xingxing , Liu Xizhi , Hu Guoliang , Dong Yang 
Published: January 2024

Background::
Dapagliflozin is commonly used to treat type 2 diabetes mellitus
(T2DM). However, research into the specific anti-T2DM mechanisms of dapagliflozin remains
scarce.

Objective::
This study aimed to explore the underlying mechanisms of dapagliflozin against
T2DM.

Methods::
Dapagliflozin-associated targets were acquired from CTD, SwissTargetPrediction,
and SuperPred. T2DM-associated targets were obtained from GeneCards and DigSee. VennDiagram
was used to obtain the overlapping targets of dapagliflozin and T2DM. GO and KEGG
analyses were performed using clusterProfiler. A PPI network was built by STRING database
and Cytoscape, and the top 30 targets were screened using the degree, maximal clique centrality
(MCC), and edge percolated component (EPC) algorithms of CytoHubba. The top 30 targets
screened by the three algorithms were intersected with the core pathway-related targets to obtain
the key targets. DeepPurpose was used to evaluate the binding affinity of dapagliflozin with the
key targets.

Results::
In total, 155 overlapping targets of dapagliflozin and T2DM were obtained. GO and
KEGG analyses revealed that the targets were primarily enriched in response to peptide, membrane
microdomain, protein serine/threonine/tyrosine kinase activity, PI3K-Akt signaling pathway,
MAPK signaling pathway, and AGE-RAGE signaling pathway in diabetic complications.
AKT1, PIK3CA, NOS3, EGFR, MAPK1, MAPK3, HSP90AA1, MTOR, RELA, NFKB1,
IKBKB, ITGB1, and TP53 were the key targets, mainly related to oxidative stress, endothelial
function, and autophagy. Through the DeepPurpose algorithm, AKT1, HSP90AA1, RELA,
ITGB1, and TP53 were identified as the top 5 anti-targets of dapagliflozin.

Conclusion::
Dapagliflozin might treat T2DM mainly by targeting AKT1, HSP90AA1, RELA,
ITGB1, and TP53 through PI3K-Akt signaling.
HPLC Analysis of Vitamins C, E, Beta-carotene, and Some Flavonoids in
Armenian Red Wines
Authors: Grigoryan Ani A. , Hayrapetyan Ani A. , Azaryan Zhermen A. , Harutyunyan Siranush V. , Yengoyan Aleksandr P. 
Published: January 2024

Background:
Oxidative damage to biological molecules is mainly caused by free radicals
produced in the body. Natural antioxidants can prevent the resulting oxidative stress. For this purpose,
particularly grapes and grape products, which contain vitamins and polyphenolic substances
with high antioxidant activity, are used.

Methods:
In the present study, the content of vitamins C and E, beta-carotene, and some flavonoids
(+)-catechin, quercetin, and trans-resveratrol) in the composition of 19 brands of red wines that are
produced in Armenia, was determined by HPLC. Vitamins C, E, beta-carotene, as well as flavonoids
manufactured by Sigma-Aldrich were used as standards.

Results:
The amounts of vitamin E and beta-carotene were below the sensitivity threshold of the
method, and the content of vitamins C and flavonoids varied over a wide range (vitamins C 2.15-
56.1, (+)-catechin 0-620.3; quercetin 0-10.55; trans-resveratrol 0-5.89 mg/L).

Conclusion:
The chromatographic analysis of vitamins and flavonoids allowed us to investigate not
only the content of useful substances that make up red wines but also to identify counterfeit products.
In this study, wines presented directly to retailers were analyzed since the task was both to determine
vitamins and flavonoids and to identify counterfeits. The results of our study showed that among all
the selected wine brands, there were no samples that, in terms of their properties, would not meet the
required parameters.
Differentiation of Acute Leukemia Cells Including Cells with MLL-AF4 Rearrangements Induced by Jiyuan Oridonin A
Authors: Li Xueming , Zhang Fenglian , Ke Yu , Liu Hongmin , Hu Zhenbo , Wei Liuya 
Published: January 2024

Background:
Chromosomal rearrangements involving the Mixed lineage leukemia
(MLL) gene are observed in acute leukemia (AL) patients, which have poor prognosis, especially
in infants. Hence, there is still a challenge to develop other effective agents to treat AL with MLL
rearrangements (MLLr). MLL has been shown to rearrange with partner genes, of which the most
frequently observed are AF4 and AF9. Moreover, AL is characterized by a differentiation blockage
resulting in the accumulation of immature cells. An ent-kaurene diterpenoid compound, Jiyuan
Oridonin A (JOA), has been shown to reduce the viability of AML cells by differentiation.

Methods:
We aimed to evaluate the effect of JOA on the growth and differentiation of AL cells
(SEM, JURKAT and MV4-11) including cells with MLLr-AF4 by cell proliferation assay, colony
formation assay, cell cycle analysis, cell apoptosis analysis, measurement of cell surface
antigens and cell morphology, mRNA-sequencing analysis, quantitative Real-time PCR and
Western blotting analysis.

Results:
Our findings demonstrated that the proliferation of AL cells including cells with
MLLr-AF4 was significantly suppressed by JOA, which induced cell differentiation followed
by G0/G1 cell cycle withdrawal. Moreover, JOA-mediated cell differentiation was likely due to
activation of G-CSFR in MV4-11 cells.

Conclusion:
Our results suggest that JOA may be considered a promising anti-leukemia compound
to develop to surmount the differentiation block in AL patients
Vesicular Nanocarriers: A Potential Platform for Topical/Transdermal
Delivery of Antibiotics
Authors: Chadha Mohit , Malik Deepinder Singh 
Published: January 2024

Background:
Bacterial infections are becoming difficult to treat nowadays due to the development of resistance towards conventional treatments. Conventional topical formulations loaded
with antibiotics display various disadvantages, like high dosing frequency, high toxicity, and poor
patient compliance. The former limitations may sometimes lead to severe complications and hospitalization of patients. However, these can be overcome by employing vesicular nanocarriers for the delivery of antibiotics following the topical/transdermal route.

Objective:
The objective of this review paper was to summarize the role of vesicular nanocarriers, like
liposomes, elastic liposomes, niosomes, ethosomes, solid lipid nanoparticles, nanostructured lipid carriers, and nanoemulsions for topical/transdermal delivery of antibiotics, and patents associated with them.

Methods:
Literature for the present review was collected using various search engines, like PubMed,
Google Scholar, and Google Patents.

Results:
Various literature investigations have revealed the in vitro and preclinical efficacy of vesicular nanocarrier systems in the delivery of antibiotics following the topical/transdermal route.

Conclusion:
Vesicular nanocarrier systems, via targeted delivery, may subside various side effects of
antibiotics associated with conventional delivery, like high dosing frequency and poor patient compliance. However, their existence in the pharmaceutical market will be governed by effective clinical
assessment and scale-up methodologies.
Literature Review on IoT-based Smart Retailing Management Systems in the Context of Smart Cart
Authors: Gupta Paras , Verma Gourav , Chauhan Aakash , Singh Neha , Pandey Meghna , Kukreti Kamlesh , Joshi Alankrita 
Published: January 2024

Abstract:
IoT technology has revolutionized retail, giving rise to Smart Retailing Management
Systems (SRMS). This review explores IoT-based SRMS focusing on smart carts, investigating
enhancements in shopping experiences like RFID tags, dynamic inventory management, and personalization.
By comparing research and products, it evaluates SRMS in technology, cost, reliability,
security, power use, and components. The goal is to unveil SRMS’s strengths and weaknesses,
aiding retail progress.

Objective:
This study aimed to review IoT-based Smart Retailing Management Systems (SRMS)
centered on smart carts, explore IoT's role in enhancing shopping, spotlighting RFID tags, dynamic
inventory, and personalization, and evaluate SRMS via tech, cost, reliability, security, power,
and components, unveiling diverse strengths and weaknesses.

Method:
A literature search in previous works and patents was conducted. The findings to pinpoint
trends, tech shifts, and research gaps were analyzed. The real-world studies were synthesized
to discuss IoT-based SRMS progress and an inclusive view of various approaches and outcomes
was offered.

Conclusion:
IoT-based SRMS, especially in smart retail carts, elevate shopping via RFID tags,
dynamic inventory, and personalization. The comparative analysis exposes SRMS potential and
constraints, offering insights for informed retail decisions and advancement.
The Radioprotective Effect of LBP on Neurogenesis and Cognition after Acute Radiation Exposure
Authors: Yin Gang , Wang Qinqi , Lv Tongtong , Liu Yifan , Peng Xiaochun , Zeng Xianqin , Huang Jiangrong 
Published: January 2024

Background:Radiation exposure has been linked to the development of brain damage and cognitive impairment, but the protective effect and mechanism of Lycium barbarum pills (LBP) on radiation-induced neurological damage remains to be clarified.Methods:Behavioral tests and immunohistochemical studies were conducted to evaluate the protective effects of LBP extract (10 g/kg orally daily for 4 weeks) against radiation-induced damage on neurogenesis and cognitive function in Balb/c mice exposed to 5.5 Gy X-ray acute radiation.objective:To study the protective effect and mechanism of Lycium barbarum pills(LBP) on radiation induced neurological damage.Results:The results showed that the LBP extract significantly improved body weight loss, locomotor activity and spatial learning and memory. Immunohistochemical tests revealed that the LBP extract prevented the loss of proliferating cells, newly generated neurons and interneurons, especially in the subgranular area of the dentate gyrus.Conclusion:The findings suggest that LBP is a potential neuroprotective drug for mitigating radiation-induced neuropsychological disorders.
Studi Manajemen Konstruksi Proyek Pembangunan Pelimpah Pada Bendungan Bendo Metode Fasttrack dan Crashing
Authors: Muhammad Dien Azmi , Pitojo Tri Juwono  , Evi Nur Cahya  
Published: January 2024

Pelaksanaan proyek kontruksi membutuhkan perancanaan yang matang agar dapat terselesaikan secara efektif dan efisien. Proyek Pembangunan Pelimpah Pada Bendungan Bendo Kabupaten Ponorogo dimana dalam pelaksanaanya memiliki banyak sub item sehingga diperlukan manajemen kontruksi yang tepat agar pembangunannya dapat mencapai target secara efektif dan efisien. Waktu, biaya dan mutu merupakan tiga hal penting yang harus diperhatikan dalam suatu proyek konstruksi. Pada studi ini untuk mempercepat waktu penyelesaian proyek digunakan metode fasttrack dan crashing. Hal tersebut dilakukan dengan cara merekayasa lintasan kritis dan melakukan percepatan penjadwalan sehingga berdampak pada efektivitas durasi proyek. Dari hasil analisa dengan metode fasttrack, dilakukan optimasi dengan menghasilkan durasi proyek yang lebih efektif yaitu 5,9% dari durasi awal kontrak dan menghasilkan biaya proyek yang lebih efisien yaitu 0,3% dari biaya proyek. Dengan menggunakan metode crashing, dilakukan optimasi dengan menambah jam kerja selama 2 jam pada sumberdaya manusianya. Dari optimasi tersebut dengan menghasilkan durasi proyek yang lebih efektif yaitu 2,9% dari durasi awal kontrak dan menghasilkan biaya proyek yang lebih efisien yaitu 0,51% dari biaya proyek. Dari hasil optimasi didapatkan hasil bahwa metode fasttrack lebih unggul dalam segi optimasi jadwal proyek. Sedangkan, metode crashing lebih unggul dalam proyeksi anggaran (biaya akhir proyek).
Office Workers’ Views About the Uses, Concerns, and Acceptance of Hand Hygiene Data Collected From Smart Sanitizers: Exploratory Qualitative Interview Study
Authors: Rutter Sophie , Sanger Sally , Madden Andrew D , Ehdeed Sukaina , Stones Catherine 
Published: January 2024

Background
COVID-19 and the prospect of future pandemics have emphasized the need to reduce disease transmission in workplaces. Despite the well-established link between good hand hygiene (HH) and employee health, HH in nonclinical workplaces has received little attention. Smart sanitizers have been deployed in clinical settings to motivate and enforce HH. This study is part of a large project that explores the potential of smart sanitizers in office settings.

Objective
Our previous study found that for office workers to accept the deployment of smart sanitizers, they would need to find the data generated as useful and actionable. The objectives of this study were to identify (1) the potential uses and actions that could be taken from HH data collected by smart sanitizers (2) the concerns of office workers for the identified uses and actions and (3) the circumstances in which office workers accept HH monitoring.

Methods
An interview study was conducted with 18 office workers from various professions. Interview questions were developed using a framework from personal informatics. Transcripts were analyzed thematically.

Results
A wide range of uses of smart sanitizer data was identified including managing hygiene resources and workflows, finding operating sanitizers, communicating the (high) standard of organizational hygiene, promoting and enforcing organizational hygiene policies, improving workers’ own hygiene practices, executing more effective interventions, and identifying the causes of outbreaks. However, hygiene is mostly considered as a private matter, and it is also possible that no action would be taken. Office workers were also concerned about bullying, coercion, and use of hygiene data for unintended purposes. They were also worried that the data could be inaccurate or incomplete, leading to misrepresentation of hygiene practices. Office workers suggested that they would be more likely to accept monitoring in situations where hygiene is considered important, when there are clear benefits to data collection, if their privacy is respected, if they have some control over how their data are collected, and if the ways in which the data will be used are clearly communicated.

Conclusions
Smart sanitizers could have a valuable role in improving hygiene practices in offices and reducing disease transmission. Many actionable uses for data collected from smart systems were identified. However, office workers consider HH as a personal matter, and acceptance of smart systems is likely to be dynamic and will depend on the broad situation. Except when there are disease outbreaks, smart systems may need to be restricted to uses that do not require the sharing of personal data. Should organizations wish to implement smart sanitizers in offices, it would be advisable to consult widely with staff and develop systems that are customizable and personalizable.
FINITE ELEMENT ANALYSIS FOR DYNAMIC RESPONSE OF VISCOELASTIC SANDWICHED STRUCTURES INTEGRATED WITH ALUMINUM SHEETS
Authors: Elmoghazy Yasser Hamed , Safaei Babak , Sahmani Saeid 
Published: January 2024

Passive vibration attenuation of modern mechanical structures is one of the most essential technologies applied to the arsenal of modern mechanical structures. In this work, dynamics analysis is performed on viscoelastic (VE) sandwich beam and plate by using finite element method. The proposed structure is composed of a VE core and aluminum face sheets as substrate layers on both sides of the structure. Small-strain VE material is modeled based on complex constant moduli model and numerical method is used to develop the finite element (FE) shear model based on first-order shear deformation theory (FSDT) and Hamilton principle. In modal analysis, model-effective mass analysis is performed to investigate its dominant mode shape and sweet spot at resonance using C3D20 and CPS8 elements. The former is indicated as a 3-D element with 20 nodes while the latter is indicated as a 2-D plane strain element with eight nodes. In harmonic analysis, resonance frequency is obtained based on mode superposition method to evaluate the steady-state response of VE sandwich beam via maximum deformation. Thereafter, the results are compared against analytical solutions from the literature. Moreover, a parametric study shows that the natural frequency of the beam did not change with the increase in core thickness. However, normalized loss factor of VE sandwich beam is directly proportional to VE damping factor and the thickness of VE core layer. Based on frequency response function, the results of resonance frequencies for VE beam are in the range of modal natural frequency.
Poszukiwanie równowagi ekonomiczno-ekologicznej i etycznej w produkcji mleka
Authors: Runowski Henryk 
Published: January 2024

W opracowaniu podjęto próbę określenia przyczyn występujących dysproporcji w realizacji celów ekonomicznych, ekologicznych i etycznych w procesie rolniczego gospodarowania oraz wskazania sposobów przywracania równowagi między tymi celami na przykładzie chowu bydła mlecznego. Poza studiami literatury wykorzystano wyniki badań własnych przeprowadzonych w stadzie krów liczącym 256 szt. Materiał źródłowy do badań zebrano na podstawie szczegółowej analizy historii życia poszczególnych krów opisanej za pomocą wielu wskaźników hodowlano-produkcyjnych i ekonomicznych. Wskazano możliwości przywracania równowagi między celami ekonomicznymi, ekologicznymi i etycznymi w chowie bydła mlecznego
The Unintended Consequences of Audit Materiality Disclosures on Whistleblowing Intentions
Authors: Festa Mackenzie M. , Holderness D. Kip , Jones Megan M. , Riley Richard A. 
Published: January 2024

SYNOPSIS
Within the accounting profession, there exists disagreement about the merits of disclosing auditors’ materiality thresholds. Professional standards require materiality threshold disclosures in the United Kingdom and The Netherlands but not in the United States. Additionally, some audit firms, like PwC-Finland and PwC-Sweden, elect to disclose materiality voluntarily. Although disclosing materiality has been shown to benefit investor decision-making, prior research also suggests that client personnel may take advantage of the information to engage in earnings manipulations below the materiality threshold. We contribute to this debate by examining the influence of materiality disclosures on employee whistleblowing intentions. We conduct an experiment wherein we manipulate materiality threshold disclosure (absent or present) and earnings manipulation amount (above or below materiality). We find evidence that the disclosure of the materiality threshold significantly decreases whistleblowing intentions when earnings manipulation falls below materiality and has no effect on whistleblowing intentions for above-materiality earnings manipulation.
Data Availability: The data are available from the authors.
Sharing the Wealth: The Effects of Announced TCJA Bonuses on Employee Pay Satisfaction
Authors: Hutchens Michelle , Lynch Daniel P. , Stomberg Bridget 
Published: January 2024

ABSTRACT
Many corporations publicly announced plans to share windfalls from the Tax Cuts and Jobs Act (TCJA) with rank-and-file employees. We examine the association between these bonus announcements and workers’ pay satisfaction. Although employees are better off upon receiving the bonuses, prior literature suggests employees can be dissatisfied with awards they perceive as small or inequitable. By linking the bonuses to a corporate tax windfall, firms provided a reference point for employees to assess fairness. Using a difference-in-differences design, we find a greater decline in pay satisfaction at firms announcing a TCJA bonus relative to firms that do not. We also provide evidence of greater dissatisfaction among employees who perceive their share of the windfall as unfairly small. Considering increasing income disparity in the U.S. and a heightened focus on corporate taxes, we provide new and timely insights into how workers respond to changes in compensation linked to corporate tax savings.
Data Availability: Data are available from the sources cited in the text.
JEL Classifications: H25; M52.
Modification of the Intensity of Compounds Biosynthesis in the Petioles of Rhubarb (Rheum rhaponticum L.) Induced by the Ozonation Process
Authors: Zardzewiały Miłosz , Matłok Natalia , Piechowiak Tomasz , Balawejder Maciej 
Published: January 2024

Abstract
Rhubarb (Rheum rhaponticum L.) is a vegetable that, despite many health-promoting properties, contains large amounts of oxalic acid, which has a negative impact on human health. Treatment of rhubarb petioles with gaseous ozone is one way to improve their quality by changing their chemical properties. As part of the research, an analysis of the mechanical and chemical properties of rhubarb petioles was performed. The analyzes showed that the applied doses of ozone of 10 ppm during 1, 3 and 5 minutes lowered the concentration of oxalic acid during 5 days of tests performed after the ozonation treatment. The most favorable effect on the reduction of oxalic acid, amounting to 36%, was caused by gaseous ozone at a concentration of 10 ppm during 5 minutes compared to the control. In addition, it was noted that on the 1st and 3rd day after using ozone gas, the antioxidant activity of the tested raw material increased significantly. Also on the same days of testing, the total amount of polyphenols increased as a result of the use of ozone fumigation. The largest increase in the total amount of polyphenols, amounting to 12%, was observed for a dose of 10 ppm 5 minutes on the 1st day after the ozonation treatment compared to the control variant. In turn, no positive effect of the ozonation process on the content of vitamin C and the value of destructive force during three-point bending of rhubarb leaf petioles was noted.
Effects of Extrusion Cooking Over Roasting on Retention of Nutritional Quality of Composite Flour Prepared From Soyabean, Millet, Corn and Rice Blend
Authors: Acharya Priti , Karki Sunita , Rai Kishor , Sangroula Adit 
Published: January 2024

Abstract
The objective of this study was to compare the effects of extrusion cooking and roasting on the nutritional composition of the blend obtained from rice, soybean, millet and corn flours. Two different flour compositions with different proportions of ingredients were prepared. Roasting process was conducted at 160°C for a duration of 30 minutes, whereas extrusion cooking was performed at 129°C for approximately 5 minutes. Chemical analysis was carried out on all four samples. The findings revealed that the moisture and carbohydrate content in the extrusion-cooked samples (A and B) were higher than in the roasted samples (A’ and B’). In contrast, crude fat content, crude fiber content, and ash contents were higher in roasted samples (A’ and B’) compared to extrusion-cooked samples (A and B). The protein content of samples A, A’, B and B’ was found to be 10.67%, 8.47%, 14.64% and 9.18%, respectively. This proven protein content is higher in extruded composite flours (A and B). Additionally, calcium and iron contents were higher in the roasted samples, with sample B’ having the highest calcium and iron contents. Tannin content and phytic acid content was also higher in the roasted samples, with sample B’ having the highest tannin and phytic acid content. In conclusion, extrusion cooking increased nutritional content while reducing anti-nutritional components in the composite flour, suggesting its potential as a preferred processing method to maintain nutritional quality.