bluuebunny/crossref_metadata_2025_split huggingface dataset:
Recent Advances in Nanotherapeutics and Theranostics for Squamous Cell Carcinoma: A Comprehensive Review
Authors: Sharma Neeraj , KUMAR ABHIRAM , Sambhakar Sharda , Bhatia Daksh , Hussain Sahil , Mursal Mohd , Singh Bishambar , Narayan Kumar Pranav 
Published: January 2025

Abstract:
Recent advancements in nanotherapeutics have revolutionized cancer treatment through
the integration of diagnostic and therapeutic modalities, known as theranostics. This critical review
examines the current landscape of nanotherapeutics for various cancers, such as bladder and head and
neck squamous cell carcinoma, highlighting current advancements in nanotherapeutics and challenges.
Key approaches discussed include biomimetic smart nanocarriers, polymeric smart nanocarriers,
inorganic-based smart nanocarriers, and nanorobots. Furthermore, diverse nanomaterials have been
explored in theranostics, including liposomes, polymeric nanoparticles, and inorganic nanoparticles
such as quantum dots and mesoporous silica nanoparticles. Furthermore, the integration of imaging
techniques such as surface-enhanced Raman scattering (SERS) and positron emission tomography
(PET) with therapeutic nanoparticles has been analyzed for potential clinical applications.
In Silico Pharmacogenomic Assessment of Glucagon-like Peptide-1 (GLP1) Agonists and the Genetic Addiction Risk Score (GARS) Related Pathways: Implications for Suicide Ideation and Substance Use Disorder
Authors: Sharafshah Alireza , Lewandrowski Kai-Uwe , Gold Mark S. , Fuehrlein Brian , Ashford J. Wes , Thanos Panayotis K. , Wang Gene Jack , Hanna Colin , Cadet Jean Lud , Gardner Eliot L. , Khalsa Jag H. , Braverman Eric R. , Baron David , Elman Igor , Dennen Catherine A. , Bowirrat Abdalla , Pinhasov Albert , Modestino Edward J. , Carney Paul R. , Cortese Rene , Fiorelli Rossano Kepler Alvim , Schmidt Sergio , Pollack Aryeh R. , Badgaiyan Rajendra D. , Blum Kenneth 
Published: January 2025

Introduction:
Glucagon-Like Peptide-1 Receptor (GLP1R) agonists have become widespread
anti-obesity/diabetes pharmaceuticals in the United States.

Aim:
This article aimed to provide our current knowledge on the plausible mechanisms linked to the
role of Ozempic (Semaglutide), which is generalized as one of the anti-addiction compounds.

Methods:
The effects of GLP1R agonists in Alcohol Use Disorder (AUD) and substance use disorder
(SUD) are mediated, in part, through the downregulation of dopamine signaling. We posit that while
GLP1R agonism could offer therapeutic advantages in hyperdopaminergia, it may be detrimental in
patients with hypodopaminergia, potentially leading to long-term induction of Suicidal Ideation (SI).
The alleged posit of GLP1 agonists to induce dopamine homeostasis is incorrect. This study refined
31 genes based on the targets of Ozempic, GLP1R, and related enzymes for SI and 10 genes of the
Genetic Addiction Risk Score (GARS) test. STRING-MODEL refined 29 genes, and further primary
analyses indicated associations of GLP1R with DRD3, BDNF, CREB1, CRH, IL6, and DPP4.

Results:
In-depth silico enrichment analysis revealed an association between candidate genes and
depressive phenotypes linked with dopaminergic signaling. Finally, through primary and in-depth
silico analyses, we demonstrated multiple findings supporting that GLP1R agonists can induce depression
phenotypes.

Conclusion:
Our findings suggest that associated polymorphisms seem to have overlapping effects
with addictive behaviors of Reward Deficiency Syndrome (RDS) and dopamine regulation. Consequently,
GLP1R agonists may represent a double-edged sword, potentially triggering both antiaddictive
effects and SI by exacerbating depressive phenotypes. Thus, we encourage the scientific
community to perform further empirical clinical studies to confirm this proposed pathway.
Stable Gastric Pentadecapeptide BPC 157 as a Therapy of Severe Electrolyte Disturbances in Rats
Authors: Grubisic Marija Medvidovic , Strbe Sanja , Barisic Ivan , Balenovic Dijana , Stambolija Vasilije , Lozic Marin , Ostojic Sanja Barsic , Oreskovic Ivana , Zizek Helena , Brcic Klara , Coric Luka , Staresinic Mario , Blagaic Vladimir , Oreskovic Lidija Beketic , Halle Zeljka Belosic , Matek Danijel , Soldo Dragan , Grizelj Boris , Blagaic Alenka Boban , Skrtic Anita , Sikiric Predrag , Seiwerth Sven 
Published: January 2025

Abstract:
This review explores the therapeutic potential of the stable gastric pentadecapeptide BPC
157 in addressing electrolyte imbalances, specifically hyperkalemia, hypokalemia, hypermagnesemia,
and hyperlithemia. In hyperkalemia, BPC 157 demonstrated a comprehensive counteractive effect
against KCl overdose (intraperitoneally, intragastrically, and in vitro), effectively mitigating
symptoms such as muscular weakness, hypertension, sphincter dysfunction, arrhythmias, and lethality.
It also counteracted the adverse effects of succinylcholine and magnesium overdose, including
systemic muscle paralysis, arrhythmias, and hyperkalemia. In hypokalemia, BPC 157 (administered
prophylactically or therapeutically, intraperitoneally or intragastrically) prevented fatal outcomes
and addressed furosemide-induced hypokalemia, ECG changes, AV conduction block, ventricular
arrhythmias, and skeletal muscle myoclonus. Following magnesium overdose, BPC 157 alleviated
muscle weakness, brain lesions, and hyperkalemia-induced complications. In vitro studies (HEK293
cells) revealed the ability of BPC 157 to counteract hyperkalemia- and hypermagnesemia-induced
depolarization and hypokalemia-induced hyperpolarization. In lithium intoxication, BPC 157 promoted
collateral pathway activation, resolved vascular and multiorgan failure, and counteracted advanced
Virchow triad conditions and occlusion-like syndromes. Collectively, these findings underscore
the therapeutic promise of BPC 157 in managing electrolyte imbalances and warrant further
investigation.
Developing the Learning Curve Model to Enhance Construction Project Scheduling and Cost Estimating
Authors: Salman Alaa , Sodangi Mahmoud 
Published: January 2025

Aim
The aim of the study is to develop a scheduling and cost estimation model for repetitive construction units by applying the learning curve theory and to contribute to advancements in construction project management practices, promoting efficiency and competitiveness within the industry.

Background
Construction projects, particularly those with repetitive units like housing developments, face ongoing challenges in accurate scheduling and cost estimation. Traditional estimation methods often overlook the impact of learning effects, which can improve productivity and reduce costs as crews gain experience. Learning curve theory, widely applied in manufacturing, offers a framework to model these gains in construction settings. Integrating learning curves into project planning has the potential to enhance accuracy in forecasting timelines and budgets, ultimately improving project efficiency and resource management.

Objective
The objective of this study is to develop and apply a learning curve model to enhance scheduling and cost estimation in repetitive construction projects, particularly in a multi-unit housing project.

Methods
By incorporating historical data and analyzing critical factors that impact project duration and cost, a more reliable forecasting model is developed. The learning curves are created using a three-point approach, supported by artificial neural networks (ANN) and the relative importance index (RII), to systematically assess cost divisions and influential project factors.

Results
The results indicate that the learning curve model can achieve time savings of 27% and labor cost savings of 36% compared to traditional estimation methods that do not consider the effect of the learning curve in construction projects.

Conclusion
This research demonstrates that learning curve models, combined with advanced data analysis techniques, provide a robust framework for optimizing project schedules and budgets, ultimately leading to more efficient resource utilization and cost-effective project outcomes. In other words, the study presented in this paper is significant as it can lead to improved project outcomes, cost savings, better resource management, and overall advancement in the construction industry's practices and competitiveness. This approach allows for accurate scheduling and cost forecasting based on data-driven insights.
Development and Psychometric Properties of a Tool Related to the Adoption of Desirable Behaviors in the Consumption of Sugar-sweetened Beverages in Children Based on the Social Cognitive Theory
Authors: Mostafavi Firoozeh , Heidari Zahra , Paknahad Zamzam , Sharafkhani Naser 
Published: January 2025

Background
Consumption of sugar-sweetened beverages is associated with chronic diseases such as diabetes and cardiovascular disorders and other severe negative health consequences and is one of the challenging issues in the field of nutrition in today's societies. This study was conducted with the aim of designing a psychometric questionnaire in relation to the consumption behavior of sugar-sweetened drinks in children.

Methods
In this cross-sectional research, 607 students were selected and included in the study by multi-stage cluster sampling from the first-year secondary schools covered by the Urmia Department of Education. Waltz's method was used to design the questionnaire, and based on a targeted review of the literature and questionnaires related to nutrition behavior, an initial questionnaire with 51 items was designed. After confirming the face and content validity of the questionnaire by 15 members of the expert panel, construct validity steps were performed using exploratory factor analysis. Finally, the internal reliability of the questionnaire was determined by calculating Cronbach's alpha.

Results
The first version of the questionnaire was designed with 51 items and all the items were retained in the psychometric process during content validity. The content validity index and ratio were calculated to be higher than 0.79 and 0.6, respectively. Based on the exploratory factor analysis, the number of items in the questionnaire remained at 51, and the dimensions of the questionnaire were categorized into 6 factors: perceived barriers, self-efficacy, self-regulation, social support, preventive behaviors, and reinforcing behaviors, with a predictive power of 56,261 and in repeating the exploratory factor analysis for items with a different nature from other factors, 3 separate factors were identified: the physical health dimension of outcome expectations, negative outcome expectations, and positive outcome expectations with a predictive power of 54.667. The internal reliability of the questionnaire items was accepted and confirmed with Cronbach's alpha coefficient above 0.70.

Conclusion
The final questionnaire with 51 items has the ability to be used by various researchers due to the strength of the factorial structure and suitable psychometric properties.
Firmware Over the Air for Securely Updating ECUs of the Vehicle
Authors: Mudhivarthi Bhavesh Raju , Thakur Prabhat , Kumar Alok , Anturkar Sagar , Singh G 
Published: January 2025

Introduction:
An automobile is a software-defined machine on top of the wheels including
more than 100 electronic control units (ECU) with million lines of code. The integration of ECU
in the automobile ensures the customer’s needs by providing safety, security, entertainment, and
comfort features.

Method:
The firmware integrated into the ECU should be updated to avoid latency in operation and
bugs, and to add new features. The traditional update process of ECU holds loopholes like more waiting
time, unavailability of service centers, and security threats. To overcome this, over-the-air (OTA)
updates are introduced in the vehicle, but security is the major concern while transmitting firmware
over the air.

Result:
The proposed system ensures the wireless firmware update with the uptane framework with
background Timestamp Update Framework (TUF) ensures the security. The timestamp generated is
valid for 86400 seconds to validate the freshness. In addition, security assessment and reverse engineering
are performed on the designed system to check for security breaches.

Conclusion:
The system secures the firmware over arbitrary and replay attacks on the Original
Equipment Manufacturer (OEM) server.
Epidemiologic Investigation of Eye Symptoms Related to COVID-19 among Outpatient Population
Authors: Eslami Fatemeh , Khazaei Salman , Eslamighayour Anahita , Mohammadi Tahere 
Published: January 2025

Background:
Since 2019, with the spread of coronavirus and the emergence of new strains worldwide, various studies have identified the effects of this virus on multiple organs of the body.

Objective:
Individuals with COVID-19 experience various symptoms in their body systems. Some of these symptoms can affect the visual system and lead to blurry vision, dry eyes, foreign body sensations, tearing, etc. These symptoms can cause early eye fatigue and re-duce the quality of academic and occupational performance.

Method:
This study aimed to investigate the ocular symptoms and treatments in outpatients with mild to moderate COVID-19 at the Vali-e-asr Clinic in Hamadan City. The study was cross-sectional with the ethics code IR.UMSHA.REC.1401.913, and was conducted from April, 2021, until the required sample size was achieved. Patients were selected using an available non-probability sampling method.

Results:
The findings indicated that the pandemic had a significant impact on the employ-ment status of individuals, particularly full-time and part-time employees or workers, as well as university students. Additionally, in our study, significant increases in various eye symptoms, including blurred vision, fluctuating vision, the need to increase text size while reading, and eye irritation, were reported.

Conclusion:
Based on our study on the impact of COVID-19 on dry eye, we found a sig-nificant increase in dry eye symptoms among patients with a history of COVID-19. It is essential to raise awareness among individuals, healthcare professionals, and policymakers about the possible consequences of the pandemic on eye health and to implement appropri-ate measures to mitigate these effects.
Empowering Communities In Transformative Transport Decision-making: A Participatory Spatial Approach to Select Vulnerable Facilities for Citizen Sensing
Authors: Giuffrida Nadia , Le Pira Michela 
Published: January 2025

Introduction/Background
This paper presents the first steps of the BEC2SCHOOL project, aimed at providing communities and policy-makers with methods and tools to enhance public participation in transport decision-making and foster the co-design of sustainable mobility solutions, taking advantage of smart technologies and data.

Materials and Methods
The methodology to select the most suitable facilities to be involved in the project is presented. In particular, it consists of the choice of the criteria to be selected based on different features, such as the presence of infrastructures for cycling and pedestrian mobility and users’ exposure to traffic externalities. These criteria are used for a spatial analysis aimed at identifying the priority of interventions and paving the way for the next steps of the project.

Results
The main results show that traffic is considered the most important critical issue, and many schools show a medium-high level of vulnerability according to the selected criteria.

Discussion
Results pave the way for further analyses that are needed to select the most suitable facilities where traffic and environmental sensors will be installed.

Conclusion
A bottom-up participatory approach will be set up, involving educational facilities and providing their users with tools to collect traffic and environmental-related data, analyze the relevant impacts and propose proper solutions to policy-makers in order to tackle the mobility challenges.
Ultrasound diagnosis of firearm damage to major arteries of the neck
Authors: Аbdullaiev R.Ya. , Lurin I.A. , Grechanyk О.I. , Аbdullaiev R.R. , Posokhov M.F. , Ibrahimova K.N. , Kazmirchuk K.A. 
Published: January 2025

Background. The presence of large vessels, many vital structures, and the lack of protection make the neck particularly vulnerable to various injuries, including gunshot wounds. The purpose was to evaluate the possibilities of ultrasonography in the diagnosis of gunshot injuries of the major arteries of the neck. Materials and methods. The analysis of the ultrasonography results in diagnosis of gunshot injuries to the large vessels of the neck in 53 injured persons was carried out. Visualization of the large vessels of the neck was carried out using linear and microconvex sensors in the frequency range of 5–10 and 4–9 MHz on the Philips HD11 device. Results. Damage to the common carotid artery was recorded in 38 cases, the internal carotid artery — in 23, the external carotid artery — in 21, the subclavian artery — in 24, the vertebral artery — in 15. The following types of damage were detected: intimal tear with flap formation in 27 cases, detachment of the intima in 45, pseudoaneurysm in 49 cases. A statistically significant difference (P < 0.01) was found between the number of pseudoaneurysms and intimal tear with flap formation (P < 0.01). Among injuries of the common carotid artery, pseudoaneurysm occurred significantly more often than intimal tear with flap formation (P < 0.01) and intimal detachment (P < 0.05). Damage to the common carotid artery was diagnosed statistically significantly more often than to the internal carotid artery (P < 0.05) and external carotid artery (P < 0.01), subclavian artery (P < 0.05), and vertebral artery (P < 0.001). Conclusions. Ultrasonography makes it possible to detect damage to all major arteries of the neck sustained due to combat trauma. Pseudoaneurysms statistically reliably prevail over intimal tear with flap formation and cervical artery dissection. Ultrasonography has sufficient sensitivity (87.8 %), specificity (60.9 %) and accuracy (82.6 %) in the diagnosis of gunshot injuries of the major arteries of the neck, as well as pseudoaneurysm (93, 75, 90.2 %, respectively).
Experience of surgical treatment of combat pancreatic trauma
Authors: Khoroshun E.M. , Khomenko I.P. , Shipilov S.A. , Makarov V.V. , Nehoduiko V.V. , Petiunin O.H. 
Published: January 2025

Background. Pancreatic injuries is a complex challenge for trauma surgeons, especially if combat, due to the presence of combined injuries and complications. The aim: to provide a structure, peculiarities of diagnosis and treatment of combat pancreatic trauma. Materials and methods. A retrospective analysis was done of medical records of 58 inpatients who sustained combat pancreatic trauma during the war in Ukraine. Their average age was 37.4 ± 3.6 years (range 21–60 years). The mechanism of combat injury included gunshot wounds (87.9 %), explosive (10.3 %) and closed injuries (1.7 %). All the wounded underwent laboratory and instrumental investigations. Results. According to the nature of the combat injury, pancreatic injuries were categorised into gunshot shrapnel wounds — 50 (86.2 %), gunshot bullet wounds — 1 (1.7 %), explosive trauma — 6 (10.3 %), and closed combat trauma — 1 (1.7 %) case. Distribution by location of pancreatic injury: tail — 38 (65.5 %), head — 11 (19 %), body — 5 (8.6 %), body and tail — 2 (3.4 %), head and tail — 2 (3.4 %) cases. The following methods of surgical intervention were used: damage control surgery (DCS) — 51 (87.9 %) cases, one-stage surgery — 7 (12.1 %) cases. Distribution by the type of surgical intervention for pancreatic injury: drainage of the parapancreatic space — 45 (77.6 %), pancreatorrhaphy — 4 (6.9 %), distal pancreatosplenectomy — 3 (5.2 %), removal of foreign bodies (metal fragments) — 3 (5.2 %), distal resection of the pancreas with spleen preservation — 1 (1.7 %), pancreatoduodenectomy — 1 (1.7 %), subtotal resection of the body and tail of the pancreas with splenectomy — 1 (1.7 %) case. Common complications (n = 42): peritonitis — 9 (21.4 %), acute surgical sepsis — 8 (19 %), acute renal failure — 7 (16.7 %), multiple organ failure syndrome — 7 (16.7 %), pneumonia — 6 (14.3 %), bleeding — 4 (9.5 %), pulmonary embolism — 1 (2.4 %). Organ-specific complications (n = 28) were as follows: acute pancreatitis — 21 (75 %), pancreatic fistula — 4 (14.3 %), pseudocysts — 2 (7.1 %), abscess — 1 (3.6 %) case. Treatment outcomes: 33 patients (56.9 %) were transferred to the next stage of treatment, 19 (32.8 %) died, and 6 (10.3 %) were discharged with a definite outcome. Mortality rate: 5 (26.3 %) died in the first 3 days, 14 (73.7 %) cases died in the period from 4 to 15 days. Conclusions. The incidence of combat pancreatic trauma among abdominal wounds is 8.7 %. Surgical treatment for combat pancreatic trauma using the DCS is performed in 87.9 % of cases, and in the volume of a single-stage operation, in 12.1 %. The DCS leads to a reduction in the incidence of complications. The overall complication rate for combat pancreatic trauma is 72.4 %, and the incidence of organ-specific complications is 48.3 %. Mortality from pancreatic injuries is 32.8 %. Combat trauma to the head of the pancreas was mainly treated with closed drainage. Distal injuries were treated by resection or drainage.
Identification, distribution, and hosts of Meloidogyne spp. infecting horticultural crops in Florida, USA with focus on Meloidogyne enterolobii
Authors: Riva Gabrieli , Brito Janete A. , de Oliveira Clemen , Marin Marcus , Gu Mengyi , Bui Hung Xuan , Desaeger Johan 
Published: January 2025

Abstract
Many root-knot nematode (RKN) species in the genus Meloidogyne occur in Florida, including M. enterolobii, a species able to overcome RKN resistance genes in many crops. The distribution of these nematodes in horticultural crops is not well known. A RKN survey was conducted in South and Central Florida aiming to: (i) identify RKN infecting vegetables, fruit, and other crops; (ii) document host plants; (iii) determine RKN distribution; and (iv) gain insight on the relatedness of M. enterolobii obtained in this study with other populations from the USA and other countries. A total of 304 soil and root samples were collected from 56 plant species cultivated in commercial vegetable and fruit farms, research farms, horticultural gardens, Asian vegetable farms, and natural landscapes in 12 counties. Meloidogyne species identification was performed using mitochondrial haplotype-based identification, species-specific primers, DNA sequencing and phylogenetic analysis. RKN were detected in 247 out of 304 (81.25%) root samples collected from September 2019 to January 2023. Five RKN species (M. arenaria, M. enterolobii, M. hapla, M. incognita and M. javanica) were identified. The most prevalent RKN were M. incognita and M. enterolobii, which were found in 25% of the samples. Less prevalent were M. javanica, found in 16%, and M. arenaria and M. hapla, found in 8% and 5% of samples, respectively. Mixed populations of M. enterolobii and M. incognita were found in 1% of the samples. Phylogenetic analysis showed low genetic variability among DNA sequences of M. enterolobii populations from Florida, other states in the USA, and other countries. New host records found in this study include: a worldwide host record, Solanum capsicoides (M. enterolobii); new US continental host records, Vigna unguiculata (M. enterolobii), Opuntia cochenillifera (mixed species – M. enterolobii and M. incognita). Additionally, new state host records found were Cannabis sativa, Colocasia esculenta, and Lilium sp. (M. arenaria), Phaseolus vulgaris (M. enterolobii), Cucumis melo (M. hapla), and Lavandula angustifolia and Helianthus annuus (M. incognita). These findings confirm the predominance of tropical RKN species, and especially of M. enterolobii, in Florida. and provide new insights into the distribution, prevalence, and hosts of RKN species in horticultural crops in Central and South Florida.