bluuebunny/crossref_metadata_2025_split huggingface dataset:
Nature-based solutions for floods AND droughts AND biodiversity: Do we have sufficient proof of their functioning?
Authors: Penning Ellis , Peñailillo Burgos Reinaldo , Mens Marjolein , Dahm Ruben , de Bruijn Karin 
Published: October 2023

Abstract
Climate change and human-modified landscapes have led to an increase in global flood and drought risks, while biodiversity has declined. The concept of using nature-based solutions (NbS) to improve the water retention capacity at the landscape scale, also known as ‘sponge functioning of catchments,’ has been recognised to help reduce and delay peak flows and stimulate infiltration to the groundwater, thus reducing flood and drought risks. Although various effects of NbS have been demonstrated, there is limited evaluation of the combined multiple benefits for flood risk reduction, drought risk reduction, and biodiversity. To address this gap, we analysed various online databases on NbS and additional literature on the evaluated combined effects of NbS. We found that the quantitative evaluation of NbS is fragmented and not standard practice in many projects. Although many successfully implemented NbS have been reported in different environments globally, most cases lack evidence for their response to the combined impacts of floods, droughts, and biodiversity. Therefore, we propose four components to facilitate planning, design, implementation, and monitoring of NbS that improve sponge functioning for floods and droughts. First, we suggest increased understanding of how NbS affects the hydrological processes of both flood and drought events along the full range of potential conditions. Second, we recommend evaluating the effect of potential NbS measures at a landscape scale. Third, we propose that integrated modelling and upscaling techniques should be improved to quantify the impacts of NbS. Finally, we suggest using a consistent and socially relevant set of indicators to evaluate the NbS and communicate this with stakeholders. In conclusion, our analysis demonstrates a need for more comprehensive and standardised evaluation of NbS, particularly in relation to their combined impacts on floods, droughts, and biodiversity.
Enhancing winter rye termination by mixing glyphosate with other herbicides using water or UAN as the carrier
Authors: Noorenberghe Olivia M. , Sikkema Peter H. , Cowbrough Michael J. , Hooker David C. , Soltani Nader , Tardif François J. 
Published: October 2023

AbstractHerbicides are often used to terminate cover crops. Producers would like to use herbicides that work quickly, are effective, and do not increase the risk of selecting herbicide-resistant weeds. Eight experiments were conducted to determine whether mixing glyphosate (900 g a.e. ha−1) with rimsulfuron (15 g a.i. ha−1), mesotrione (100 g a.i. ha−1), or rimsulfuron + mesotrione enhances winter rye control and to ascertain whether using urea ammonium nitrate (UAN) as the herbicide carrier improves and accelerates herbicide efficacy. Winter rye control was assessed 1, 2, 3, and 4 wk after application (WAA) and biomass was measured 4 WAA. The addition of rimsulfuron, mesotrione, or rimsulfuron + mesotrione to glyphosate did not enhance winter rye control. Similarly, using UAN as the herbicide carrier did not improve or accelerate herbicide efficacy. Glyphosate alone provided the greatest level of winter rye control. The addition of rimsulfuron, mesotrione, or rimsulfuron + mesotrione to glyphosate did not increase the level or speed of control. However, mixing glyphosate with rimsulfuron, mesotrione, or rimsulfuron + mesotrione adds other modes of action without compromising winter rye control.
Use of low tunnels to describe effects of herbicide, adjuvant, and target surface on dicamba volatility
Authors: Zaccaro-Gruener Maria Leticia , Norsworthy Jason K. , Piveta Leonard B. , Barber L. Tom , Mauromoustakos Andy , Mueller Thomas C. , Roberts Trenton L. 
Published: October 2023

AbstractInvestigations of the relevance of low-tunnel methodology and air sampling concerning the off-target movement of dicamba were conducted from 2018 to 2022, focused primarily on volatility. This research, divided into three experiments, evaluated the impact of herbicides and adjuvants added to dicamba and the type of surface treated on dicamba volatility. Treatment combinations included glyphosate and glufosinate, the presence of a simulated contamination rate of ammonium sulfate (AMS), the benefit of a volatility reduction agent (VRA), and a vegetated (dicamba-resistant cotton) or soil surface treated with dicamba. Volatility assessments included air sampling collected over 48 h. Dicamba treatments were applied four times to each of two bare soil or cotton trays and placed inside the tunnels. Dicamba from air samples was extracted and quantified. Field assessments included the maximum and average visible injury in bioindicator soybean and the lateral movement of dicamba damage expressed by the farthest distance from the center of the plots to the position in which plants exhibited 5% injury. Adding glufosinate and glyphosate to dicamba increased the dicamba amount in air samples. A simulated tank contamination rate of AMS (0.005% v/v) did not affect dicamba emissions compared to a treatment lacking AMS. Adding a VRA reduced dicamba in air samples by 70% compared to treatment without the adjuvant. Dicamba treatments applied on vegetation generally produced greater detectable amounts of dicamba than treatments applied to bare soil. Field assessment results usually followed differences in dicamba concentration by treatments tested. Results showed that low-tunnel methodology allowed simultaneous comparisons of several treatment combinations concerning dicamba volatility.
Effectiveness of manual lymphatic drainage and intermittent pneumatic	compression in lymphedema maintenance therapy
Authors: Mendoza Erika , Amsler Felix 
Published: October 2023

Summary: Background: To compare the effectiveness of intermittent pneumatic compression (IPC) and/or manual lymphatic drainage (MLD) associated to compression stockings in the maintenance treatment of lymphedema. Patients and methods: Patients in the maintenance phase of lymphedema therapy with MLD and compression since more than a year with stable values for weight and circumferences of ankle and calf were asked to participate in a study: Compression had to be worn daily, (1) 4 weeks IPC+MLD, (2) 4 weeks MLD alone, (3) 4 Weeks IPC alone (Order 1 and 3 was randomized). At the beginning and after each 4 weeks, circumference measurements (by hand and by machine: BT600®, Bauerfeind) were documented, pain and discomfort were assessed, and quality-of-life questionnaires were completed. Results: Of 20 participants, 18 (14 female, 4 male), mean age 59.6 years (48–89) could be evaluated. 11 subjects had bilateral, 7 unilateral, 5 primary, 13 secondary lymphedema since 2–20 years (mean 7.7), the subjects had received MLD and compression for 2–14 years (mean 6.4), 1–3 times per week (mean 1.5). The BMI ranged between 21 and 47 (mean 33.7). No differences between any phases were found for: Calf and thigh volume, circumference of calf. Only the ankle circumference was significant less (−0.22 cm) when using “both” (IPC+MLD). Compared to before the study, quality of life was better in all three phases, but with a significantly higher improvement in the phases with IPC than in the phases without. Conclusions: There were no differences in objective measurement between MLD alone, IPC alone or both, excepting the minimal significant difference in ankle circumference after IPC+MLD. QOL favored IPC application. Considering the economic consequences of these results, a change of maintenance therapy with MLD weekly over years in favor of permanent care with IPC and few appointments of MLD per year should be considered and further investigated.
Projecting Diversity Conflicts of Future Land System Pathways in China Under Anthropogenic and Climate Forcing
Authors: Lin Xin , Jiao Xin , Tian Zhiqiang , Sun Qiangqiang , Zhang Yongxiang , Zhang Ping , Ji Zhengxin , Chen Lu , Lun Fei , Chang Xiao , Liu Wen , Liu Ming , Sun Danfeng 
Published: October 2023

AbstractPredicting future land system changes driven by anthropogenic and climactic impacts can help to explore adaptation and mitigation pathways for regional and global sustainable development. Here, we project land cover changes in China from 2030 to 2100 at a resolution of 1 km × 1 km under eight scenarios based on the Scenario Model Intercomparison Project (ScenraioMIP), which are extracted from Land Use Harmonization version 2 (LUH2). We use a rule‐based method to classify and map 9 land cover dynamic trajectories at patch scale to present land system changes. At the provincial scale we used hierarchical clustering to identify archetypes of land cover change, which can predict ecological risks for future management in western provinces. Our results reveal that anthropogenic mitigation policies under high mitigation pressure do not result in positive impacts on the land system, but rising temperatures will provide a great opportunity for ecological restoration in some regions.
Paleomagnetic Constraint on the Age of the Shyok Suture Zone
Authors: Martin Craig R. , Jagoutz Oliver , Upadhyay Rajeev , van Tongeren Jill A. , Mueller Paul A. , Weiss Benjamin P. 
Published: October 2023

AbstractThe India‐Eurasia collision is a key case study for understanding the influence of plate tectonic processes on Earth's crust, atmosphere, hydrosphere, and biosphere. However, the timing of the final India‐Eurasia continental collision is debated due to significant uncertainty in the age of the collision between the Kohistan‐Ladakh arc (KLA) and Eurasia along the Shyok suture zone. Here we present paleomagnetic results that constrain the Karakoram terrane in northwest India to a paleolatitude of 19.9 ± 8.9°N between 93 and 75 million years ago (Ma). Our results show that the Karakoram terrane was situated on the southern margin of Eurasia in the Late‐Cretaceous. Our results indicate that the KLA and Eurasian continent had a not converged until <61.6 Ma, placing a Paleocene older limit on the age of final closure of the Shyok suture zone. This suggests that the India‐Eurasia collision in northwestern India likely occurred after the closure of the oceanic basin between the KLA and Eurasia. The Paleocene collision event affecting India that has been widely interpreted to represent final India‐Eurasia collision instead records the arc‐continent collision between the KLA and the northern edge of India prior to final India‐Eurasia collision. Final India‐Eurasia collision in northwest India most likely occurred after the closure of the oceanic basin between the KLA and Eurasia.
Algal Blooms in Lakes in China Over the Past Two Decades: Patterns, Trends, and Drivers
Authors: Wang Ying , Feng Lian , Hou Xuejiao 
Published: October 2023

AbstractMany lakes in China suffer from algal bloom problems. However, the spatial and temporal distribution of lacustrine algal blooms at the national scale has not been well characterized. Here, we developed an automated algal bloom surface scums (hereafter referred to as algal bloom) detection algorithm for Moderate‐Resolution Imaging Spectroradiometer (MODIS) images based on a normalized floating algal index and the Commission on Illumination colorimetry system. This algorithm was then applied to 35,556 daily MODIS images acquired between 2003 and 2020 to hindcast the spatial and temporal dynamics of lacustrine algal blooms in 171 lakes in China. The results show that 103 (60.2%) of the examined lakes have been affected by algal blooms over the past two decades, and the bloom occurrence in 95 lakes showed an increasing trend. The prevailing increasing trends of algal blooms in Chinese lakes were also manifested by an earlier onset time and prolonged potential occurrence period. We found that approximately 80% of the historical algal blooms occurred under calm water surfaces (wind speed <3 m/s) and high temperatures (>16°C), and we revealed positive correlations between bloom occurrence and fertilizer use. We further demonstrated that the increasing trends in algal blooms were highly linked to recent increases in air temperature. The results here not only highlight the severe lacustrine algal bloom problems in China but also provide important baseline information for lake management and restoration efforts for the government.
GNSS Scintillations in the Cusp, and the Role of Precipitating Particle Energy Fluxes
Authors: Ivarsen Magnus F. , Jin Yaqi , Spicher Andres , St‐Maurice Jean‐Pierre , Park Jaeheung , Billett Daniel 
Published: October 2023

AbstractUsing a large data set of ground‐based GNSS scintillation observations coupled with in situ particle detector data, we perform a statistical analysis of both the input energy flux from precipitating particles, and the observed occurrence of density irregularities in the northern hemisphere cusp. By examining trends in the two data sets relating to geomagnetic activity, we conclude that observations of irregularities in the cusp grows increasingly likely during storm‐time, whereas the precipitating particle energy flux does not. We thus find a weak or nonexistent statistical link between geomagnetic activity and precipitating particle energy flux in the cusp. This is a result of a previously documented tendency for the cusp energy flux to maximize during northward IMF, when density irregularities tend not to be widespread, as we demonstrate. At any rate, even though ionization and subsequent density gradients directly caused by soft electron precipitation in the cusp are not to be ignored for the trigger of irregularities, our results point to the need to scrutinize additional physical processes for the creation of irregularities causing scintillations in and around the cusp. While numerous phenomena known to cause density irregularities have been identified and described, there is a need for a systematic evaluation of the conditions under which the various destabilizing mechanisms become important and how they sculpt the observed ionospheric “irregularity landscape.” As such, we call for a quantitative assessment of the role of particle precipitation in the cusp, given that other factors contribute to the production of irregularities in a major way.
A Statistical Study on the Acceleration Conditions of Ultrarelativistic Electrons in the Earth's Outer Radiation Belt During Geomagnetic Storms
Authors: Chen JingRun , Tang ChaoLing , Chu Xinxin , Wang Xu , Su Zhengpeng , Ni Binbin , Zhang Jichun 
Published: October 2023

AbstractUsing the data from Van Allen Probes, we statistically study the acceleration conditions of ultrarelativistic electrons (Ek > 3 MeV) in the Earth's outer radiation belt. Based on the different high energy cutoffs of ultrarelativistic electrons, the acceleration events of ultrarelativistic electrons are divided into the four groups of “3.4 MeV events,” “5.2 MeV events,” “6.3 MeV events,” and “7.7 MeV events.” According to different solar wind and substorm conditions during the recovery stage, we classify solar wind into three categories: no high‐speed flows, short‐duration high‐speed flows, and long‐duration high‐speed flows. Substorms are divided into continuous substorm activity and non‐continuous substorm activity. Our statistical results show that (a) The different solar wind speeds can cause enhancements of ultrarelativistic electrons with different energies. The high solar wind speed is more important in the acceleration of ultrarelativistic electrons with higher energies (7.7 MeV) than lower energies (3.4, 5.2, and 6.3 MeV). (b) The different substorm activities during the recovery stage can cause enhancements of ultrarelativistic electrons with different energies. Continuous intense substorms in the early recovery stage can contribute to the rapid recovery and enhancements of ultrarelativistic electrons. The timing, intensity, and duration of substorms during the recovery stage are important to the acceleration of ultrarelativistic electrons. (c) Relativistic (1 MeV) electrons are the direct “source” of ultrarelativistic electrons (3.4, 5.2, and 6.3 MeV) in the outer radiation belt. These can help us further understand the electron dynamics of the Earth’s outer radiation belt.
Theory of an Automatic Seepage Meter and Ramifications for Applications
Authors: Zlotnik Vitaly A. , Solomon D. Kip , Genereux David P. , Gilmore Troy E. , Humphrey C. Eric , Mittelstet Aaron R. , Zlotnik Anatoly V. 
Published: October 2023

AbstractA new approach for measuring fluxes across surface water—groundwater interfaces was recently proposed. The Automatic Seepage Meter (ASM) is equipped with a precise water level sensor and digital memory that analyzes water level time series in a vertical tube inserted into a streambed (Solomon et al., 2020, https://doi.org/10.1029/2019WR026983). The ability to infer flux values with high temporal resolution relies on an accurate interpretation of water level dynamics inside the tube. Here, we reduce the three‐dimensional hydrodynamic problem that describes the ASM water level in a variety of field conditions to a single ordinary differential equation. This novel general analytical solution for estimating ASM responses is more comprehensive and flexible than previous approaches and is applicable to the entire range of field conditions, including steady or transient stream stages, evaporation, rainfall, and noise. For example, our analysis determines the timing of the nonmonotonic ASM response to a monotonic linear stream stage variation and explains previously used empirical parabolic approximation for estimating fluxes. We present algorithms for simultaneous inference of vertical interface flux and hydraulic conductivity values together with an example code. We quantify how the accuracy of parameter estimation depends on test duration and noise amplitude and propose how our analysis can be used to optimize field test protocols. On this basis, changing the ASM geometry by increasing the radius and decreasing tube insertion depth may enable ASM field test protocols that estimate interface flux and hydraulic conductivity faster while maintaining desired accuracy. Potential applications of joint parameter estimation are suggested.
Follow-up of the GHSG HD16 trial of PET-guided treatment in early-stage favorable Hodgkin lymphoma
Authors: Fuchs Michael , Jacob Anne Sophie , Kaul Helen , Kobe Carsten , Kuhnert Georg , Pabst Thomas , Greil Richard , Bröckelmann Paul J. , Topp Max S. , Just Marianne , Hertenstein Bernd , Soekler Martin , Vogelhuber Martin , Zijlstra Josée M. , Keller Ulrich Bernd , Krause Stefan W. , Dührsen Ulrich , Meissner Julia , Viardot Andreas , Eich Hans-Theodor , Baues Christian , Diehl Volker , Rosenwald Andreas , Buehnen Ina , von Tresckow Bastian , Dietlein Markus , Borchmann Peter , Engert Andreas , Eichenauer Dennis A. 
Published: October 2023

AbstractThe primary analysis of the GHSG HD16 trial indicated a significant loss of tumor control with PET-guided omission of radiotherapy (RT) in patients with early-stage favorable Hodgkin lymphoma (HL). This analysis reports long-term outcomes. Overall, 1150 patients aged 18–75 years with newly diagnosed early-stage favorable HL were randomized between standard combined-modality treatment (CMT) (2x ABVD followed by PET/CT [PET-2] and 20 Gy involved-field RT) and PET-2-guided treatment omitting RT in case of PET-2 negativity (Deauville score [DS] < 3). The study aimed at excluding inferiority of PET-2-guided treatment and assessing the prognostic impact of PET-2 in patients receiving CMT. At a median follow-up of 64 months, PET-2-negative patients had a 5-year progression-free survival (PFS) of 94.2% after CMT (n = 328) and 86.7% after ABVD alone (n = 300; HR = 2.05 [1.20–3.51]; p = 0.0072). 5-year OS was 98.3% and 98.8%, respectively (p = 0.14); 4/12 documented deaths were caused by second primary malignancies and only one by HL. Among patients assigned to CMT, 5-year PFS was better in PET-2-negative (n = 353; 94.0%) than in PET-2-positive patients (n = 340; 90.3%; p = 0.012). The difference was more pronounced when using DS4 as cut-off (DS 1-3: n = 571; 94.0% vs. DS ≥ 4: n = 122; 83.6%; p < 0.0001). Taken together, CMT should be considered standard treatment for early-stage favorable HL irrespective of the PET-2-result.
KLHL29-mediated DDX3X degradation promotes chemosensitivity by abrogating cell cycle checkpoint in triple-negative breast cancer
Authors: Yao Litong , Hao Qian , Wang Mozhi , Chen Yuhai , Cao Hongyi , Zhang Qiang , Yu Keda , Jiang Yizhou , Shao Zhiming , Zhou Xiang , Xu Yingying 
Published: October 2023

AbstractTriple-negative breast cancer (TNBC) is a heterogeneous breast cancer subtype and accounts for approximately 15–20% of breast cancer cases. In this study, we identified KLHL29, which is an understudied member of the Kelch-like gene family, as a crucial tumor suppressor that regulates chemosensitivity in TNBC. KLHL29 expression was significantly downregulated in breast cancer tissues compared with adjacent normal tissues, and low levels of KLHL29 were associated with unfavorable prognoses. Ectopic KLHL29 suppressed, while depleting KLHL29 promoted, the growth, proliferation, migration, and invasion of TNBC. Mechanistically, KLHL29 recruited the CUL3 E3-ligase to the RNA-binding protein DDX3X, leading to the proteasomal degradation of the latter. This downregulation of DDX3X resulted in the destabilization of CCND1 mRNA and the consequent cell cycle arrest at G0/G1 phase. Remarkably, the DDX3X inhibitor RK33 combined with platinum-based chemotherapy can synergistically suppress TNBC that usually expresses low levels of KLHL29 and high levels of DDX3X using cancer cell-derived xenograft and patient-derived organoids models. Altogether, we uncovered the potential role for the KLHL29-DDX3X signaling cascade in the regulation of TNBC progression, thus providing a promising combination strategy for overcoming TNBC chemoresistance.
Ligand-dependent hedgehog signaling maintains an undifferentiated, malignant osteosarcoma phenotype
Authors: Vaghjiani Vijesh G. , Cochrane Catherine R. , Jayasekara W. Samantha N. , Chong Wai Chin , Szczepny Anette , Kumar Beena , Martelotto Luciano G. , McCaw Andrew , Carey Kirstyn , Kansara Maya , Thomas David M. , Walkley Carl , Mudge Stuart , Gough Daniel J. , Downie Peter A. , Peacock Craig D. , Matsui William , Watkins D. Neil , Cain Jason E. 
Published: October 2023

AbstractTP53andRB1loss-of-function mutations are common in osteosarcoma. During development, combined loss of TP53 and RB1 function leads to downregulation of autophagy and the aberrant formation of primary cilia, cellular organelles essential for the transmission of canonical Hedgehog (Hh) signaling. Excess cilia formation then leads to hypersensitivity to Hedgehog (Hh) ligand signaling. In mouse and human models, we now show that osteosarcomas with mutations inTP53andRB1exhibit enhanced ligand-dependent Hh pathway activation through Smoothened (SMO), a transmembrane signaling molecule required for activation of the canonical Hh pathway. This dependence is mediated by hypersensitivity to Hh ligand and is accompanied by impaired autophagy and increased primary cilia formation and expression of Hh ligand in vivo. Using a conditional genetic mouse model ofTrp53andRb1inactivation in osteoblast progenitors, we further show that deletion ofSmoconverts the highly malignant osteosarcoma phenotype to benign, well differentiated bone tumors. Conversely, conditional overexpression of SHH ligand, or a gain-of-function SMO mutant in committed osteoblast progenitors during development blocks terminal bone differentiation. Finally, we demonstrate that the SMO antagonist sonidegib (LDE225) induces growth arrest and terminal differentiation in vivo in osteosarcomas that express primary cilia and Hh ligand combined with mutations in TP53. These results provide a mechanistic framework for aberrant Hh signaling in osteosarcoma based on defining mutations in the tumor suppressor, TP53.