bluuebunny/crossref_metadata_2025_split huggingface dataset:
Metagenomics reveals microbial communities and functional differences during chili pepper (Capsicum frutescens L.) natural fermentation: Effects of brines and containers
Authors: Zhang Shiyao , Bao Xi , Xiao Yue , Wang Tao , Chu Chuanqi , Hu Xiaosong , Yi Junjie 
Published: January 2024

AbstractThe study aimed to investigate the effect of fermentation brines and containers on the composition and functional dissimilarity of microbiota in fermented chili peppers: pool with fresh brine (PFB), pool with aged brine (PAB), jar with FB, and jar with AB. The results showed that brines had a greater impact on microbial diversity and fungal community structure than containers, whereas containers had a greater impact on bacterial community structure than brines. At the end of chili pepper fermentation, the dominant bacteria were unclassified_g__Pseudomonas, Lactobacillus_alimentarius, and Halococcus_thailandensis, whereas the dominant fungi were Pichia_membranifaciens and Wallemia_ichthyophaga. Based on the metagenomics functional analysis, the dominant bacteria and fungi were highly related to amino acid metabolism, glycerophospholipid metabolism, and most enzymes that promote carbohydrate substrate modulation. The fermented brines had a larger impact than containers on microbial function. Specifically, the use of FB was found to be beneficial for the biosynthesis of tetracycline, carotenoid, and isoflavonoid. On the other hand, AB was found to be beneficial for the biosynthesis of unsaturated fatty acids, amino acids, and various types of N‐glycan.
Updating Angling Records to Advance Sport Fish Conservation: A Case Study of IGFA's Black Bass World Records
Authors: Taylor Andrew T , Bellapigna Zachary L , Pohlot Bruce G 
Published: January 2024

Abstract
As taxonomic studies revise our understanding of biodiversity, both fisheries managers and the angling public must adapt to best conserve fisheries. Unfortunately, communication gaps between scientists and anglers may result in lags and inaccuracies in the taxonomic information available to anglers. We updated the International Game Fish Association (IGFA)'s black bass Micropterus spp. world records to current taxonomic consensus. Seven new species were acknowledged for all-tackle world record availability, and four of seven existing species records were revised. Florida Bass M. salmoides (formerly M. floridanus), Neosho Bass M. velox, and four members of the Redeye Bass species complex (M. cahabae, M. chattahoochae, M. tallapoosae, and M. warriorensis) are now recognized. Additionally, Alabama Bass M. henshalli—an emerging invasive species—is now distinguished from the smaller, broadly distributed Spotted Bass M. punctulatus. A misidentified specimen resulted in vacant all-tackle records for Shoal Bass M. cataractae and Redeye Bass M. coosae. Genetic verification is warranted in the future, but implementation may create accessibility barriers to record submissions. We hope these efforts will encourage anglers to learn more about black bass diversity, to pursue their own world record catches, and to gain awareness of the conservation challenges threatening this iconic group.
Development of water management strategies in southern Mesopotamia during the fourth and third millennium B.C.E.
Authors: Mantellini Simone , Picotti Vincenzo , Al‐Hussainy Abbas , Marchetti Nicolò , Zaina Federico 
Published: January 2024

AbstractThe last two decades witnessed increasing scholarly interest in the history of water management in southern Mesopotamia. Thanks to many geoarchaeological research projects conducted throughout the central and southern Iraqi floodplains, a general understanding of the macrophases of anthropogenic manipulation of this vast hydraulic landscape has been achieved. However, current narratives mostly rely on studies at a regional scale and are based on excessively long chronological phases (often spanning a whole millennium). A finer‐tuned analysis at a submillennial scale is needed to better appreciate the dynamics that led to the development of artificial canals and irrigation systems and the creation of harbours in cities and other navigation‐related facilities. The Iraqi‐Italian QADIS project is addressing this issue through a systematic geoarchaeological investigation in the south‐eastern area of the Qadisiyah province. We aim to update the current narrative by analysing case studies involving specific periods of occupation. We performed 17 boreholes to propose a date on the functioning period of the hydraulic works in five selected archaeological sites of this region. This approach allowed us to understand changes in water management strategies in both the short and the medium term (i.e., on a scale of centuries). In this paper, we present the results for the fourth and third millennia B.C.E. This period witnessed a crucial passage from the basic exploitation of natural watercourses for irrigation and occasional navigation to the emergence of the first system of artificial canals and intraurban harbours.
simmrd: An open‐source tool to perform simulations in Mendelian randomization
Authors: Lorincz‐Comi Noah , Yang Yihe , Zhu Xiaofeng 
Published: January 2024

AbstractMendelian randomization (MR) has become a popular tool for inferring causality of risk factors on disease. There are currently over 45 different methods available to perform MR, reflecting this extremely active research area. It would be desirable to have a standard simulation environment to objectively evaluate the existing and future methods. We present simmrd, an open‐source software for performing simulations to evaluate the performance of MR methods in a range of scenarios encountered in practice. Researchers can directly modify the simmrd source code so that the research community may arrive at a widely accepted framework for researchers to evaluate the performance of different MR methods.
Squeezing unsteady nanofluid flow among two parallel plates with first‐order chemical reaction and velocity slip
Authors: Maiti Hiranmoy , Mukhopadhyay Swati 
Published: January 2024

AbstractThe squeezing flow bears a major importance in everyday phenomena and has vast industrial and biomedical applications. The current study looks at the nanofluid flow among two infinite “parallel plates” that are squeezed. The velocity slip and first‐order compound response have been considered in this problem for a clear understanding of their consequences in the flow of nanofluid and heat transport mechanism. This fluid replica thinks about “Brownian motion” and the influences of “thermophoresis” of nanofluid. The novelty of this work lies in exploring the combined effects of first‐order chemical reaction and the velocity slip on unsteady squeezing flow of nanofluid between two parallel plates as one has not yet reported such effects. The prevailing equations are altered into simplified forms by deploying suitable similarity transformations. Then “numerical solutions” of these equations are obtained by applying the fourth‐order “Runge–Kutta method” with the help of the shooting technique. The accuracy is verified by using two different methods and also comparing our data with the available existing literature. The main goal is to study heat and mass transfer through unsteady squeezing plates by the influence of velocity slip and chemical reaction. The consequences of diverse pertinent parameters on fluid flow, thermal, and concentration fields have been explored in this study. With the rise in “velocity slip parameter” from 0 to 1, 81.37% decrease in skin friction coefficient, 15.81% increase in Nusselt number, and 29.13% increase in Sherwood number are observed. Rising values of the chemical reaction parameter from 0.3 to 0.5, the mass transfer coefficient increases by 66.94%.
Effective and simple interventions to improve outcomes for preterm infants worldwide: The FIGO PremPrep‐5 initiative
Authors: Hall Megan , Valencia Catalina M. , Soma‐Pillay Priya , Luyt Karen , Jacobsson Bo , Shennan Andrew ,   the FIGO Preterm Birth Committee
Published: January 2024

AbstractPreterm birth remains the leading cause of mortality among under‐5's and is a major contributor to the reduction in quality‐of‐life adjusted years and reduction in human capital. Globally, there are many interventions and care bundles that aim to reduce the impact of preterm birth once preterm labor has ensued and into the neonatal period; not all of these are applicable in all settings. Here, we introduce the FIGO PremPrep‐5 initiative, which aims to disseminate key information on the most simple and effective interventions with the aim of increasing implementation globally. Before delivery, we recommend a course of antenatal corticosteroids, and intrapartum magnesium sulfate. At delivery, we recommend delayed cord clamping. Postnatally, we recommend early feeding with breast milk and immediate kangaroo care. While there are many other interventions that may improve outcomes at the time of labor and after preterm birth, these are clinically effective and relatively inexpensive options that can be practiced in most settings and supplemented with more advanced care. We include examples of a training video and infographics that will be used for dissemination.
Rapid and non‐invasive detection of cystic echinococcosis in sheep based on serum fluorescence spectrum combined with machine learning algorithms
Authors: Xu Shengke , Dawuti Wubulitalifu , Maimaitiaili Maierhaba , Dou Jingrui , Aizezi Malike , Aimulajiang Kalibixiati , Lü Xiaoyi , Lü Guodong 
Published: January 2024

AbstractCystic echinococcosis (CE) is a grievous zoonotic parasitic disease. Currently, the traditional technology of screening CE is laborious and expensive, developing an innovative technology is urgent. In this study, we combined serum fluorescence spectroscopy with machine learning algorithms to develop an innovative screening technique to diagnose CE in sheep. Serum fluorescence spectra of Echinococcus granulosus sensu stricto‐infected group (n = 63) and uninfected E. granulosus s.s. group (n = 60) under excitation at 405 nm were recorded. The linear support vector machine (Linear SVM), Quadratic SVM, medium radial basis function (RBF) SVM, K‐nearest neighbor (KNN), and principal component analysis‐linear discriminant analysis (PCA‐LDA) were used to analyze the spectra data. The results showed that Quadratic SVM had the great classification capacity, its sensitivity, specificity, and accuracy were 85.0%, 93.8%, and 88.9%, respectively. In short, serum fluorescence spectroscopy combined with Quadratic SVM algorithm has great potential in the innovative diagnosis of CE in sheep.
Community perceptions of contributors and solutions related to neighborhood violent crime: A qualitative interview study
Authors: Stager Catanya G. , Whitfield Samantha , Osborne Tiffany , Adedoyin Christson , Okoro Grace , Carley Erin , Schoenberger Yu‐Mei , Crawford Dwayne A. , Thompson Melissa , Stafford Sharela , Bateman Lori B. 
Published: January 2024

AbstractThe current study is part of a community engaged planning phase and aimed to identify perceptions related to the prevalence of violent crime, crime contributors, the relationship between the community and law enforcement, and potential interventions and solutions. In March 2021, semistructured interviews were conducted with individuals from five groups who resided or worked in Bessemer, Alabama: (1) Law Enforcement, (2) Residents, (3) Civic Leaders, (4) Community Leaders, and (5) Victims of Crime. Interviews lasted approximately 60 min and were audio recorded, transcribed, and analyzed according to the guidelines of thematic analysis using NVivo 12. Emerging themes were examined in accordance with the CDC Social‐Ecological Model: A Framework for Prevention. Participants (N = 18) were 50.0% female and 77.8% African American with an age range of 25–59 (mean = 43.4 years). Themes that emerged related to crime were: (1) impact, (2) contributors, and (3) solutions. Results indicate that impacts of violent crime at the individual level focused on fear, which led to widespread mental health issues. Relationship level impacts included a lack of trust of law enforcement and neighbors, and community level impacts were decreased neighborhood social cohesion as well as decreased safety. At the societal level, the poor reputation of the city was consistently highlighted. For contributors of crime, being a youth under age 30, drugs, and money were discussed as factors at the individual level. At the relationship level, participants mentioned poor parenting and gangs as crime contributing factors to violent crime. Furthermore, contributing issues related to underresourced schools as well as a poor relationship with law enforcement were brought up at the community level. Similarly, poverty was the overarching contributing issue at the societal level. Solutions that emerged included: education and training in life skills, focusing on young people, family/parenting, conflict resolution programs, programs within schools, improved relationships with law enforcement, and inclusive economic opportunities. Intervention plans are discussed that can merge these stakeholder findings with other data sources.
Potential for managing pool levels in a flood‐control reservoir to increase nitrate‐nitrogen load reductions
Authors: Schilling Keith E. , Streeter Matthew T. , Anderson Elliot , Merryman Jennifer , Isenhart Thomas , Arenas‐Amado Antonio , Theiling Chuck 
Published: January 2024

AbstractFew strategies are available to reduce nitrate‐nitrogen (NO3‐N) loads at larger landscape scales, but flood control reservoirs are known to reduce riverine loads. In this study, we evaluated the potential to increase nitrogen (N) loss at Lake Red Rock, a large reservoir located in central Iowa, by evaluating the inundation of sediments deposited at the reservoir inflow. Sediment samples were collected at 51 locations in the lower delta region and analyzed for particle size and nutrient content. Nitrogen loss rates in delta sediments were determined from laboratory assays, and satellite imagery was used to develop a rating curve to quantify land area inundated within the delta. The daily mass of NO3‐N reduced with delta inundation was estimated by applying the mean N 24‐h loss rate (0.66 g N m2 day−1) by the area of inundation (m2). Results indicated that raising pool elevations to inundate more of the delta would result in greater N losses, ranging from 2 to 377 Mg per year. Potential N loss of 102 Mg achieved by increasing pool stage by 0.5 m would be equivalent to installing nearly 650 edge‐of‐field practices in the watershed. Although more work is needed to integrate with an existing environmental pool management plan, study results indicate that reservoir management could achieve N reductions at a novel landscape scale.
Proton pump inhibitors in esophageal atresia: A systematic review and meta‐analysis
Authors: Dimitrov Georges , Aumar Madeleine , Duhamel Alain , Wanneveich Mathilde , Gottrand Frédéric 
Published: January 2024

AbstractGastroesophageal reflux disease (GERD) is frequent and prolonged in esophageal atresia (EA) pediatric patients requiring routine use of proton pump inhibitors (PPIs). However, there are still controversies on the prophylactic use of PPIs and the efficacy of PPIs on GERD and EA complications in this special condition. The aim of the study is to assess the prophylactic use of PPIs in pediatric patients with EA and its complications. We, therefore, performed a systematic review including all reports on the subject from 1980 to 2022. We conducted meta‐analysis of the pooled proportion of PPI—and no PPI groups using random effect model, meta‐regression, and estimate heterogeneity by heterogeneity index I2. Thirty‐eight reports on the topic met the criteria selection, representing a cumulative 6044 patients with EA. Prophylactic PPI prescription during the first year of life does not appear to prevent GERD persistence at follow‐up and is not associated with a significantly reduced rate of antireflux surgical procedures (ARP). PPIs improve peptic esophagitis and induce remission of eosinophilic esophagitis at a rate of 50%. Their effect on other GERD outcomes is uncertain. Evidence suggests that PPIs do not prevent anastomotic stricture, Barrett's esophagus, or respiratory complications. PPI use in EA can improve peptic and eosinophilic esophagitis but is ineffective on the other EA complications. Side effects of PPIs in EA are almost unknown.
Sciadonic acid ameliorates cyclophosphamide‐induced immunosuppression by modulating the immune response and altering the gut microbiota
Authors: Chen Lin , Jiang Qihong , Yao Shiwei , Jiang Chenkai , Lu Hongling , Hu Wenjun , Yu Shaofang , Li Mingqian , Feng Yongcai , Tan Chin Ping , Xiang Xingwei , Shen Guoxin 
Published: January 2024

AbstractBACKGROUNDCyclophosphamide (Cy) is a frequently used chemotherapeutic drug, but long‐term Cy treatment can cause immunosuppression and intestinal mucosal damage. The intestinal mucosal barrier and gut flora play important roles in regulating host metabolism, maintaining physiological functions and protecting immune homeostasis. Dysbiosis of the intestinal flora affects the development of the intestinal microenvironment, as well as the development of various external systemic diseases and metabolic syndrome.RESULTSThe present study investigated the influence of sciadonic acid (SA) on Cy‐induced immunosuppression in mice. The results showed that SA gavage significantly alleviated Cy‐induced immune damage by improving the immune system organ index, immune response and oxidative stress. Moreover, SA restored intestinal morphology, improved villus integrity and activated the nuclear factor κB signaling pathway, stimulated cytokine production, and reduced serum lipopolysaccharide (LPS) levels. Furthermore, gut microbiota analysis indicated that SA increased t beneficial bacteria (Alistipes, Lachnospiraceae_NK4A136_group, Rikenella and Odoribacter) and decreased pathogenic bacteria (norank‐f‐Oscillospiraceae, Ruminococcus and Desulfovibrio) to maintain intestinal homeostasis.CONCLUSIONThe present study provided new insights into the SA regulation of intestinal flora to enhance immune responses. © 2024 Society of Chemical Industry.
Clinical outcomes in patients with adamantinoma: Report from the bone and soft tissue tumor registry in Japan
Authors: Shimizu Junya , Emori Makoto , Murahashi Yasutaka , Kawai Akira , Teramoto Atsushi 
Published: January 2024

AbstractBackgroundAdamantinomas are rare malignant bone tumors. Due to their low incidence, there are few reports on the clinical results of adamantinoma.ObjectivesThis study aims to clarify outcomes in patients with adamantinoma using data from the National Bone and Soft Tissue Tumor Registry.MethodsFrom 2006 to 2019, 38 cases of tibial origin were included. Twenty‐four were male and 14 were female, with a mean age of 37 (6–87) years and a mean follow‐up of 35 (1–128) months.ResultsSurgery was performed in 33 cases (87%) (curettage: 4 cases, wide resection: 27 cases, amputation: 2 cases). Reconstruction was performed in 27 patients who underwent wide resection. A total of 12 additional surgeries were performed in 11 patients. The main reason for the additional surgeries was nonunion of grafting bone in 6 cases. Oncologic outcomes were DOC (death from other causes) in one case and NED (no evidence of disease) in 37 cases.ConclusionsThe results of treatment of adamantinomas in Japan have been extremely favorable. This may be due in part to the large number of cases with wide resection.
The effect of Covid‐19 depression on spirituality and psychological well‐being through the perceived environmental restorativeness of a pilgrimage route: Focusing on pilgrims on Seoul Catholic Pilgrimage Route
Authors: Kim Jinok Susanna , Lee Dong Cheol , Cho Hangun , Jo Hyeyoung 
Published: January 2024

AbstractDuring the COVID‐19 pandemic, policies adopted by various countries to prevent the spread of the disease exacerbated social isolation among people, and their prolonged implementation has had a negative effect on people's mental health, leading to increased anxiety, stress, and depression. Group religious activities were prohibited, so believers continued their faith practices through individual pilgrimages. Therefore, the purpose of this study is to clarify the relationship between depression caused by COVID‐19 and its impact on spirituality and psychological well‐being, through the perceived restorative environment of the Seoul Catholic Pilgrimage Route. The results confirmed that COVID‐19 depression had a negative effect on perceived environmental restorativeness and psychological well‐being but perceived environmental restorativeness had a positive effect on Spirituality, and Spirituality had a positive effect on psychological well‐being. These results imply that pilgrims who have experienced depression due to the pandemic can improve their spirituality and psychological well‐being through nature‐based pilgrimages.
Sezary syndrome revealed by PD‐L1 blockade for tumor stage mycosis fungoides
Authors: Delaleu Jérémie , Battistella Maxime , Ram‐Wolff Caroline , Moins‐Teisserenc Hélène , Ta Van‐Anh , Roelens Marie , Rivet Jacqueline , Lebbé Céleste , Mourah Samia , Louveau Baptiste , Bouaziz Jean‐David , Bagot Martine , de Masson Adèle 
Published: January 2024

AbstractCutaneous T‐cell lymphomas (CTCLs) are unique non‐Hodgkin lymphomas due to the proliferation of skin‐homing T cells. Sezary syndrome (SS), a subtype of CTCL, typically presents as erythroderma with specific blood involvement and seldomly evolves from tumor‐stage mycosis fungoides (MF). The article examines the case of a 62‐year‐old female patient who developed SS while under atezolizumab treatment for tumor‐stage transformed MF. Postdiagnosis, she underwent treatments including topical corticosteroids, phototherapy, and other drug regimens, experiencing both complete responses and relapses over the years. Three years postdiagnosis, her condition deteriorated with facial tumor lesions, confirmed as MF. Despite multiple treatments, including oral drugs, radiation therapy, and a range of other therapeutic agents, her condition did not show sustained improvement. The patient was then administered atezolizumab, an antibody targeting programmed death ligand 1 (PD‐L1). Although initial results saw a disappearance of her skin tumors, the subsequent cycles led to symptoms consistent with stage IVA1 SS, coupled with an evident shift in malignant T‐cell clone dominance. Atezolizumab, a humanized monoclonal antibody, impedes the interaction of PD‐L1 with its receptor PD1, which is notably overexpressed in malignant T‐cells of SS. This case illustrates the emergence of SS during the course of atezolizumab treatment for a transformed MF condition, underlining the potential risks and complexities in using PD‐L1 inhibitors for treating CTCL.