bluuebunny/crossref_metadata_2025_split huggingface dataset:
The role of Statistical Data and Metadata Exchange in global statistical infrastructure
Authors: Díaz Muñoz Pedro 
Published: January 2025

The attention given by statistical organisations to Statistical Data and Metadata Exchange (SDMX) is currently at unprecedented levels. This paper analyses the reasons for this and describes the key elements of this infrastructure. Furthermore, it describes all the dimensions of the SDMX initiative, namely, the standards, the exchange of data in different modes and the opportunity for the sharing of tools; and it links all these dimensions to the corresponding infrastructure elements. The paper also summarises the governance aspects of the initiative and outlines the benefits of adopting SDMX in an organisation, including the use of the data model in the statistical productions chain and to profit from the available components. Finally, a reflection on the global implementation of SDMX, as recommended by the United Nations Statistical Commission in February 2008, is provided in this paper. Finally, the paper urges national and international statistical organisations in the world to implement SDMX standards and guidelines and to use them in their exchanges of data; to participate in the governance mechanisms; and to act as a relay for promoting the use of SDMX by other partners. Readers can find more information about the topics dealt with in this paper in the SDMX official website at http://www.sdmx.org/.
Trajectory modelling of longitudinal non-response in business surveys
Authors: Smaill Kate 
Published: January 2025

Survey quality is an important goal for National Statistics Offices(NSOs) and non-response negatively affects this quality. Accordingly, it is important to understand the determinants and patterns of non-response, with the aim of providing recommendations as to how to reduce or mitigate non-response. This study looks to better categorise sampled firms based on their previous response behaviour, using trajectory modelling. Trajectory modelling is a tool for distinguishing patterns of behaviour over time, with dual trajectory modelling allowing us to analyse how outcomes in one time period are related to distinct outcomes in time two [6]. Using dual trajectory modelling to examine longitudinal response patterns is a new application of this model. Statistics New Zealand's Retail Trade Survey is used as a test case and the model is fitted across the response history 2003 to 2007.We were able to identify three response groups, the good-responders, the group whose likelihood of response improves over time and the non-respondents. These three groups then form the basis for four groups we identified in time two. This then informs some tentative recommendations as how to best target sample members, based on previous response behaviour.
Debates presidenciales: entre el ritual democrático y el simulacro político
Authors: Cruz Facundo , Reina Augusto 
Published: January 2025

Este artículo examina el rol de los debates presidenciales en las democracias modernas como avatares del debate público democrático. Se argumenta que, más allá de su función informativa, los debates actúan como simulacros de la democracia realmente existente, simbolizando los rituales y las representaciones que sostienen la legitimidad del sistema político.

A través de una visión crítica, se reflexiona sobre cómo estos eventos, a menudo percibidos eventos de deliberación pública, también funcionan como ceremonias de legitimación y actos de autoridad de las campañas políticas. Los debates se presentan así no sólo cómo actos de la comunicación electoral, sino como escenarios performativos que, aunque refuercen ciertas nociones democráticas, también reflejan las limitaciones y contradicciones inherentes al sistema político contemporáneo.

El capítulo concluye que, aunque los debates presidenciales cumplen un papel simbólico crucial, su efectividad en la promoción de un diálogo genuino y la formación de una ciudadanía informada sigue siendo objeto de debate. Estos eventos, aunque imperfectos, encapsulan las tensiones entre la realidad democrática y su representación ritualizada, revelando tanto las fortalezas como las debilidades de la democracia en la práctica.
Uso de GeoGebra en el aprendizaje de secciones cónicas de geometría analítica y su incidencia en rendimiento académico de los estudiantes de nivelación universitaria
Authors: Brito Mancero Luis Fabian , Brito Mancero Marcela Yolanda 
Published: January 2025

Introducción. El rendimiento de la matemática en el bachillerato en el Ecuador es bajo ya que las metodologías enseñanza aprendizaje se centran en métodos tradicionales, en caso de la geometría analítica suele centrarse en un tratamiento algebraico de las figuras lo que contribuye a que los estudiantes presenten dificultades en la adquisición de nuevos conocimientos durante la universidad. Objetivo. Analizar comparativamente el rendimiento académico que alcanzan los estudiantes de nivelación universitaria en la asignatura de Geometría analítica en el tema cónicas, cuando en el proceso enseñanza-aprendizaje se hace uso de una herramienta didáctica tecnológica como el software libre GeoGebra frente a la enseñanza-aprendizaje tradicional. Metodología. Se partió de la hipótesis que el aprendizaje de cónicas con el uso del programa GeoGebra incide de manera significativa en el rendimiento académico. Para lo cual se identificó un grupo control y un grupo experimental de los estudiantes de Geometría analítica, se realizó la descripción del desenvolvimiento en los subtemas circunferencia, parábola, elipse e hipérbola con el método tradicional y con el uso de GeoGebra; finalmente se correlaciona los rendimientos académicos alcanzados por cada grupo; para la recolección de datos se utilizó aplicó una prueba diagnóstica, cuatro talleres uno por cada subtema trabajado y una prueba global final. Resultados. En la evaluación diagnostica se encontró que los rendimientos de los estudiantes provenientes del bachillerato se encuentran por debajo del 70%; el aprendizaje de las secciones circunferencia, parábola y elipse se demostró que existe diferencia significativa a favor del aprendizaje con el uso de GeoGebra. Conclusión. El introducir metodologías tecnológicas en el proceso enseñanza aprendizaje mediante el uso de GeoGebra en el estudio de secciones cónicas incide de forma positiva en la adquisición de conocimientos. Área de estudio general: Educación. Área de estudio específica: Secciones cónicas. Tipo de estudio: Artículos originales.
Higher Life’s Crucial 9 protects against infertility among U.S. women aged 18–45 years
Authors: Huang Shaoqun , Duan Shuqin , Choi Seok , Gong Hongyang 
Published: January 2025

ObjectiveInfertility is not only a reproductive issue but is also closely linked to cardiovascular health and other factors. Life’s Crucial 9 (LC9) is a set of lifestyle guidelines aimed at improving cardiovascular health, yet its potential association with infertility remains underexplored. This study aims to investigate the relationship between LC9 and infertility, providing new insights and strategies for the prevention and management of infertility.MethodsThis study utilized data from the National Health and Nutrition Examination Survey (NHANES) from 2013 to 2018. Multivariate logistic regression and weighted quantile sum (WQS) regressions were employed to investigate the association between LC9 and infertility. Restricted cubic spline (RCS) analysis explored the linear or non-linear relationship between LC9 and infertility. Interaction analyses were conducted on subgroups to validate the findings.ResultsThere was a significant negative association between LC9 and infertility. After adjusting for covariates, for every 10-point increase in LC9, there was a 35% decrease in the prevalence of infertility (P &lt; 0.001). This negative correlation persisted when LC9 was divided into quartiles. Moreover, as LC9 increased, there was a trend towards lower infertility prevalence (P for trend &lt; 0.001). WQS analyses showed consistent associations (OR=0.27, 95%CI: 0.14, 0.53), with sleep health score, psychological health score, and Body mass index score as significant factors. The dose-response curve indicated a linear association between LC9 and infertility, with higher LC9 associated with lower infertility risk.ConclusionThe results of this study show a strong negative correlation between LC9 and the prevalence of infertility. Clinically, these findings offer hope for infertility patients, suggesting that adherence to a higher LC9 score significantly reduces the risk of infertility. This will provide a new avenue for infertility prevention and management, offering hope and potential relief to infertile patients.
Phase-dependent iron depletion differentially regulates the niche of intestinal stem cells in experimental colitis via ERK/STAT3 signaling pathway
Authors: Wang Shubin , Liu Xiangjun , Xu Lu , Lang Jinyi , Liu Dengqun 
Published: January 2025

IntroductionUlcerative colitis (UC) is a global gastrointestinal disease, which is mainly caused by both dysfunctional epithelial barrier and inflammation response. Iron is a critical fundamental element for both the maintenance of homeostasis and the mediation of inflammation in many tissues. However, the role and mechanism of iron in the phase of enteritis and the subsequent repairing phase of intestinal stem cells has not been elucidated. In this study, we aimed to explore whether and how iron depletion would affect the occurrence and outcome of experimental colitis.MethodsIron depletion was realized by deferoxamine (DFO) at either the early stage or late stage of dextran sulfate sodium (DSS) induced experimental colitis in mice. The gross images of colons, general health, histology, barrier integrity, and qRT-PCR were performed. Meanwhile, cell culture and colonic organoids were used to examine the influence of iron depletion in vitro. Signaling pathway and inflammatory infiltration were investigated by immunostaining.ResultsIron depletion within the early stage of DSS treatment significantly inhibited the onset of the inflammatory response, maintained the integrity of the colonic epithelium, and preserved the activity of intestinal stem cells (ISCs) both in vivo and in vitro. However, both continuous iron depletion by DFO and late DFO treatment aggravated colonic injury and postponed the recovery from colitis. Early DFO-induced iron depletion was able to maintain the p-STAT3 and p-ERK1/2 signaling pathways within the colonic epithelium at the early phase of colitis, but late DFO treatment inhibited the activity of these two pathways.DiscussionOur study demonstrated that the manipulation of iron depletion by DFO might greatly affect the outcomes of experimental colitis in a phase-dependent manner, which suggests that the balance of iron metabolism might be an effective therapeutic target for the clinical treatment of IBD patients.
Effects of the Paediatric Regulation funding on the development of off-patent medicines in children
Authors: Ruggieri Lucia , Torretta Silvia , Giannuzzi Viviana , Natale Alessandra , Felisi Mariagrazia , Ceci Adriana , Bonifazi Fedele 
Published: January 2025

IntroductionIn paediatrics, medicines repurposing is a particularly advantageous approach, offering a route to address unmet medical needs and turn off-label use into evidence-based treatments for paediatric populations. This study analysed the effects of funds provided under the Seventh Framework Programme for Research (FP7-FRP), issued by the European Commission from 2007 to 2013 according to the European Paediatric Regulation, in terms of new paediatric marketing authorisations (MAs) including paediatric Use Marketing Authorisations (PUMAs). Additionally, we investigated which funded projects included repurposing initiatives.MethodsData was collected on paediatric Investigation Plans (PIPs), new MAs, and MAs variations from the EMA website, national medicine registers, and final project reports. A survey to project coordinators was also conducted to explore the challenges faced during paediatric drug development plans.ResultsThe 20 FP7-funded projects studied 24 off-patent active substances. Eighteen substances had agreed PIPs with the European Medicines Agency paediatric Committee (PDCO). Positive compliance checks were granted for three PIPs, resulting in three new PUMAs. According to the adopted definition, 22 out of 24 (91.6%) paediatric development plans could be classified as repurposing. New conditions were proposed for eight substances, while 16 aimed to extend existing indications to broader paediatric populations. Additionally, 18 development plans included new age-appropriate formulations. The survey revealed that primary challenges in paediatric development plans included budgeting, lengthy regulatory processes, and recruitment.DiscussionTaken together, these results highlighted on one hand that the FP7 programme had a positive impact, as three new PUMAs were effectively obtained, representing one third of the nine PUMAs obtained since the paediatric Regulation entered into force, and three out of 18 agreed PIPs were successfully completed within 3–10 years. In addition, repurposing existing drugs for paediatric use significantly contributed to addressing unmet medical needs in paediatrics. On the other hand, the gap between the number of agreed PIPs and those that have led to PUMAs is still considerable, due to regulatory barriers and financial constraints. This underscores the need for continued support and further initiatives to streamline public-private partnerships for paediatric drug development, ensuring that off-patent medicines can be safely and effectively repurposed for paediatric use.
Prediction of traditional Chinese medicine for diabetes based on the multi-source ensemble method
Authors: Yang Bin , Chi Qingyun , Li Xiang , Wang Jinglong 
Published: January 2025

IntroductionTraditional Chinese medicine (TCM) prescriptions are generally formulated by experienced TCM researchers based on their expertise and data statistical methods.MethodsIn order to predict TCM formulas for diabetes more accurately, this paper proposes a novel multi-source ensemble prediction method that combines machine learning ensemble techniques and multi-source data. In this method, the multi-source data contain datasets based on the components and targets (DPP-4 and GLP-1). Gradient boosting decision tree (GBDT), flexible neural tree (FNT), and Light Gradient Boosting Machine (LightGBM) algorithms are trained using these two types of datasets, respectively. The compound dataset from the TCMSP database is then used as testing data to predict and screen the active ingredients. The frequencies of occurrences of medicinal herbs corresponding to these three algorithms are obtained, each containing an active ingredient list. Finally, the frequencies of occurrences of the medicinal herbs obtained from the three algorithms using the component and target datasets are integrated to select duplicate drugs as the candidate drugs for diabetes treatment.ResultsThe identification results reveal that theproposed ensemble method has higher accuracy than GBDT, FNT, and LightGBM. The medicinal herbs predicted include Lycii fructus, Amygdalus communis vas, Chrysanthemi flos, Hippophae fructus, Mori folium, Croci stigma, Maydis stigma, Ephedrae herba, Cimicifugae rhizoma, licorice, and Epimedii herba, all of which have been proven effective in the treatment of diabetes.DiscussionsThe results of network pharmacology show that myrrha can play a role in treating diabetes through multiple targets and pathways.
Inclusive Subclasses of Bi-Univalent Functions Defined by Error Functions Subordinate to Horadam Polynomials
Authors: Al-Hawary Tariq , Frasin Basem , Breaz Daniel , Cotîrlă Luminita-Ioana 
Published: January 2025

In this paper, by utilizing error functions subordinate to Horadam polynomials, we introduce the inclusive subclasses A(a, ς, r, u,η, ρ, σ), B(a, ς, r, u, τ, θ) and C(a, ς, r, u, τ, θ) of bi-univalent functions in the symmetric unit disk U. For functions in these subclasses, we derive estimations for the Maclaurin coefficients |k2| and |k3|, as well as the Fekete–Szegö functional. Additionally, some related results are also obtained.
Quelques toponymes issus de la petite végétation en Champagne-Ardenne (suite) : le jonc
Authors: Tamine Michel 
Published: January 2025

Après une étude sur la toponymie du buis publiée dans la précédente livraison de la
NRO , nous proposons une recherche consacrée aux empreintes toponymiques laissées par le jonc en Champagne-Ardenne. Nous avions initialement prévu d’y associer une recherche consacrée au sureau, ces deux volets offrant la complémentarité de variations morphologiques et phonétiques pour le premier, et de variations lexicales pour le second. Cependant, la situation sanitaire que nous connaissons actuellement interdisant tout déplacement, la consultation de documents d’archives relatifs à la seconde partie de ce travail n’était pas possible, ce qui explique que cet article ne traite finalement que de la première. Il expose la question en considérant les toponymes majeurs et la microtoponymie, s’attache aux relations existant entre ces deux plans, et éclaire quelques aspects de la variation, en particulier sur les plans morphologique et phonétique.
EFFECT OF CONSERVATION AGRICULTURE ON WATER CONSUMPTION OF BARLEY AND MUNGBEAN IN GYPSIFEROUS DESERT SOIL
Authors: Mohammed A. M. AL-Rawi  , Mohammed H. Bahia  
Published: January 2025

The field experiment was carried out during 2021-2022 in the Lower Al-Jazeera region at Anbar - Iraq. The study aimed to find the effect of conservation tillage and coverage practice on water use and consumption of crops in gypsum desert soil in two seasons using two cover crops (Barley and Mung bean). The experiment was carried out on abandoned land, so the covering (straw) was added when planting barley, and then the barley residual was kept when planting Mung bean. Non-inversion tillage was used by the digger plow. Randomly four treatments, tillage covering T.C, tillage no-covering T.NC, no-tillage covering NT.C, and no-tillage no-covering NT.NC was distributed on 12 experimental units by using RCBD design. Irrigation under sprinkler system. Results showed a significant effect of the T treatments on water consumption (ETa) in the winter season in the Mid-stage, with a difference of 16% from the NT, and for the C treatments in the Div-tage, with a difference of 37.6% from the NC. In the Inti-stage of the summer season, the T and C treatments used significantly less water by 18% and 13% compared to the NT and NC treatments, respectively. While in consumption ETa, showed a significant difference for T treatments by 6% less than NT in the Inti-stage and for C treatments in the Dev-stage by 13 % less than NC. The interference treatments T.C least and NT.NC higher used and consumed.
La paura ha il colore di un Suv. Voci di donne iraniane
Authors: Giunchi Elisa 
Published: January 2025

From restricted freedoms to enforced dress codes and abuses by the “morality police”, Iranian women face a multitude of pressures that restrict their access to public space, stifle their personal and professional ambitions and instil fear in their every-day life. The fear of repercussions for seeking basic rights, the constant surveillance over their lives and the threat of punitive measures for non-conformity lead to a pervasive sense of insecurity and uncertainty about the future and to forms of self-censoring that persist even after leaving Iran. After a brief contextual analysis, the article delves into the lived experiences of these women, highlighting their voices and stories. Through a series of interviews of Iranian women, most of whom left their country in the last few years and currently reside in Europe, we explore the fears that shape their reality, thus gaining insight also into the broader socio-political issues at play in contemporary Iran.
Blaski i cienie animacji w Bohemii
Authors: Giżycki Marcin 
Published: January 2025

Wydana niedawno płyta DVD Czeski film animowany 1925-1945 (Český animovaný film 1925-1945) zawiera wiele interesujących filmów, które pozwalają zrewidować utarte opinie o początkach animacji w Czechosłowacji. Największymi perłami w tej antologii są dzieła Karela i Ireny Dodalów, Herminy Týrlovej oraz sławnego pioniera animacji lalkowej Węgra György Pála, który uciekając z Berlina po przejęciu władzy w Niemczech przez Hitlera, zatrzymał się w Pradze. Dla polskiego odbiorcy zaskoczeniem są filmy zrealizowane przez najwybitniejszych czeskich animatorów podczas II wojny światowej (wówczas rozpoczynających swoje kariery), które dowodzą, że mimo okupacji produkcja filmowa nad Wełtawą rozwijała się całkiem dobrze.
Análise da distribuição espaço-temporal de tartarugas-marinhas em Arraial do Cabo, Rio de Janeiro
Authors: Azeredo Muniz Raquel , Mattos Pereira de Souza Pedro , Mello Fonseca Juliana , Soares Cruz Fábio , Soares Mariana , Leal Tavares Thiago , Mercedes Strauch Júlia Célia 
Published: January 2025

A região de Arraial do Cabo, estado do Rio Janeiro no Brasil, abriga uma alta biodiversidade marinha, além de fornecer importante zona de alimentação e abrigo para as espécies de tartarugas-marinhas na região sudeste do Brasil. Destarte, o presente trabalho tem por objetivo analisar os registros sobre a presença e a distribuição espacial de espécies de tartarugas-marinhas em Arraial do Cabo, Rio de Janeiro. Tais registros foram realizados por meio de embarcação seguindo transectos lineares desenhados para a porção oceânica e para a porção protegida do cabo, ao longo de oito campanhas, entre 2019 e 2021. As tartarugas-marinhas observadas ao longo dos transectos foram identificadas, fotografadas e registrado seu posicionamento espacial. Também foram registrados dados abióticos como temperatura superficial da água do mar, velocidade e direção do vento. Para a análise da distribuição espacial das tartarugas-marinhas foram analisados os parâmetros abióticos e elaborados mapas de densidade usando uma função kernel. Como resultado foram identificadas quatro espécies: Lepidochelys olivacea, Caretta caretta, Chelonia mydas e Dermochelys coriacea, sendo estas duas últimas as mais abundantes. Ambas as espécies apresentaram padrão de agregação espacial nas porções oceânica e protegida do cabo. Todavia, o padrão entre as espécies foi temporalmente distinto: a presença da espécie C. mydas foi registrada ao longo de todo o período de estudo, enquanto D. coriacea foi registrada somente em novembro 2019. Características ecológicas de cada uma das espécies, além da distribuição de manchas de plâncton gelatinoso, podem explicar estes padrões de dispersão e densidade. Essas informações são relevantes para subsidiar a implementação de ações de preservação.
Cuidado y educación de las primeras infancias en la ciudad de San Luis: espacios y derechos
Authors: Ibaceta Debora Lorena , Orellano Alejandra Ivon 
Published: January 2025

Como educadoras de Nivel Inicial, formadoras de formadores de las carreras de Educación Inicial, coordinado e integrado la Comisión de Carreras de Educación Inicial, como también forma parte de un equipo de gestión de una carrera de posgrado en torno a las primeras infancias en la Facultad de Ciencias Humanas de la UNSL, nos preocupa y ocupa conocer cómo se organizan y funcionan las instituciones maternales que cuidan, atienden, acompañan y educan a las infancias en la ciudad de San Luis. Por ello, y como punto de partida, consideramos necesario relevar los espacios formales y no formales por los que transitan las niñeces entre 45 días y 3 años de edad.
En este marco y considerando la importancia de estas instituciones para el cuidado, atención y educación de las primeras infancias, creemos que es indispensable relevar cuáles son las instituciones maternales habilitadas y en funcionamiento, así como indagar su regulación y supervisión para posibilitar algunos análisis y reflexiones al respecto.