bluuebunny/crossref_metadata_2025_split huggingface dataset:
Associations of Maternal Educational Level, Proximity to Green Space During Pregnancy, and Gestational Diabetes With Body Mass Index From Infancy to Early Adulthood: A Proof-of-Concept Federated Analysis in 18 Birth Cohorts
Authors: Cadman Tim , Elhakeem Ahmed , Vinther Johan Lerbech , Avraam Demetris , Carrasco Paula , Calas Lucinda , Cardol Marloes , Charles Marie-Aline , Corpeleijn Eva , Crozier Sarah , de Castro Montserrat , Estarlich Marisa , Fernandes Amanda , Fossatti Serena , Gruszfeld Dariusz , Guerlich Kathrin , Grote Veit , Haakma Sido , Harris Jennifer R , Heude Barbara , Huang Rae-Chi , Ibarluzea Jesús , Inskip Hazel , Jaddoe Vincent , Koletzko Berthold , Lioret Sandrine , Luque Veronica , Manios Yannis , Moirano Giovenale , Moschonis George , Nader Johanna , Nieuwenhuijsen Mark , Andersen Anne-Marie Nybo , McEachen Rosie , de Moira Angela Pinot , Popovic Maja , Roumeliotaki Theano , Salika Theodosia , Santa Marina Loreto , Santos Susana , Serbert Sylvain , Tzorovili Evangelia , Vafeiadi Marina , Verduci Elvira , Vrijheid Martine , Vrijkotte T G M , Welten Marieke , Wright John , Yang Tiffany C , Zugna Daniela , Lawlor Deborah 
Published: October 2023

Abstract
International sharing of cohort data for research is important and challenging. We explored the feasibility of multicohort federated analyses by examining associations between 3 pregnancy exposures (maternal education, exposure to green vegetation, and gestational diabetes) and offspring body mass index (BMI) from infancy to age 17 years. We used data from 18 cohorts (n = 206,180 mother-child pairs) from the EU Child Cohort Network and derived BMI at ages 0–1, 2–3, 4–7, 8–13, and 14–17 years. Associations were estimated using linear regression via 1-stage individual participant data meta-analysis using DataSHIELD. Associations between lower maternal education and higher child BMI emerged from age 4 and increased with age (difference in BMI z score comparing low with high education, at age 2–3 years = 0.03 (95% confidence interval (CI): 0.00, 0.05), at 4–7 years = 0.16 (95% CI: 0.14, 0.17), and at 8–13 years = 0.24 (95% CI: 0.22, 0.26)). Gestational diabetes was positively associated with BMI from age 8 years (BMI z score difference = 0.18, 95% CI: 0.12, 0.25) but not at younger ages; however, associations attenuated towards the null when restricted to cohorts that measured gestational diabetes via universal screening. Exposure to green vegetation was weakly associated with higher BMI up to age 1 year but not at older ages. Opportunities of cross-cohort federated analyses are discussed.
Pollen production in olive cultivars and its interannual variability
Authors: Rojas-Gómez M , Moral J , López-Orozco R , Cabello D , Oteros J , Barranco D , Galán C , Díez C M 
Published: October 2023

Abstract

Background and Aims
Olive (Olea europaea subsp. europaea var. europaea) is the most extensively cultivated fruit crop worldwide. It is considered a wind-pollinated and strictly outcrossing crop. Thus, elevated pollen production is crucial to guarantee optimum fruit set and yield. Despite these facts, the variability of pollen production within the cultivated olive has been scarcely studied. This study aimed to characterize this feature by analysing a representative set of worldwide olive cultivars.

Methods
We evaluated the average number of pollen grains per anther in 57 principal cultivars over three consecutive years. We applied a standard generalized linear model (GLM) approach to study the influence of cultivar, year and the previous year’s fruit load on the amount of pollen per anther. Additionally, the K-means method was used for cluster analysis to group cultivars based on their pollen production capacity.

Key Results
Pollen production per anther was highly variable among olive cultivars. The cultivar significantly accounted for 51.3 % of the variance in pollen production and the year for 0.3 %. The interaction between the two factors explained 8.4 % of the variance, indicating that not all cultivars were equally stable in producing pollen across the years. The previous year’s fruit load and its interaction with the year were significant, but barely accounted for 1.5 % of the variance. Olive cultivars were classified into four clusters according to their capacity to produce pollen. Interestingly, the fourth cluster was composed of male-sterile cultivars, which presumably share this character by inheritance.

Conclusions
Pollen production per anther varied extensively within the cultivated olive. This variation was mainly driven by the cultivar and its interaction with the year. The differential capacity of olive cultivars to produce pollen should be considered not only for designing new orchards but also gardens where this species is used as an ornamental.
Cyclone: open-source package for simulation and analysis of finite dynamical systems
Authors: Dimitrova Elena S , Knapp Adam C , Stigler Brandilyn , Stillman Michael E 
Published: October 2023

Abstract

Motivation
While there are software packages that analyze Boolean, ternary, or other multi-state models, none compute the complete state space of function-based models over any finite set. Results: We propose Cyclone, a simple light-weight software package which simulates the complete state space for a finite dynamical system over any finite set.

Availability and implementation
Source code is freely available at https://github.com/discretedynamics/cyclone under the Apache-2.0 license.
Community development via performing art: considering a community theatre intervention
Authors: Viola Erica , Fedi Angela , Bosco Anna Carla , De Piccoli Norma 
Published: October 2023

Abstract
This paper contributes to a reflection on the relationship between community development and performing art. It discusses the possible effects of a community theatre with regard to social and cultural capital, social inclusion, and audience development in Turin (Italy). This form of artistic production can promote social ties and participation in cultural activities and increase social and cultural inclusion, key values in community development. We examine audience characteristics, development, and appreciation as the primary indicators of success, as perceived by selected stakeholders, within the context of a single case study. The intervention involved a heterogeneous audience of people who usually do not participate in neighbourhood activities and/or attend artistic-theatrical performances. As stated by the stakeholders, the project was appreciated and its impact on the citizenry was positive, particularly for the cognitive and emotional involvement and the heightened awareness of often hidden or unknown problems and resources. Limitations are also discussed.
Prognostic significance and clinical utility of left atrial reservoir strain in transcatheter aortic valve replacement
Authors: von Roeder Maximilian , Maeder Mauritius , Wahl Vincent , Kitamura Mitsunobu , Rotta detto Loria Johannes , Dumpies Oliver , Rommel Karl-Philipp , Kresoja Karl-Patrik , Blazek Stephan , Richter Ines , Majunke Nicolas , Desch Steffen , Thiele Holger , Lurz Philipp , Abdel-Wahab Mohamed 
Published: October 2023

Abstract

Aims
Patients with diastolic dysfunction (DD) experience worse outcomes after transcatheter aortic valve replacement (TAVR). We investigated the prognostic value and clinical utility of left atrial reservoir strain (LARS) in patients undergoing TAVR for aortic stenosis (AS).

Methods and results
All consecutive patients undergoing TAVR between January 2018 and December 2018 were included if discharge echocardiography and follow-up were available. LARS was derived from 2D-speckle-tracking. Patients were grouped into three tertiles according to LARS. DD was analysed using the ASE/EACVI-algorithm. The primary outcome was a composite of all-cause death and readmission for worsening heart failure 12 months after TAVR. Overall, 606 patients were available [age 80 years, interquartile range (IQR) 77–84], including 53% women. Median LARS was 13.0% (IQR 8.4–18.3). Patients were classified by LARS tertiles [mildly impaired 21.4% (IQR 18.3–24.5), moderately impaired 13.0% (IQR 11.3–14.6), severely impaired 7.1% (IQR 5.4–8.4), P &lt; 0.0001]. The primary outcome occurred more often in patients with impaired LARS (mildly impaired 7.4%, moderately impaired 13.4%, and severely impaired 25.7%, P &lt; 0.0001). On adjusted multivariable Cox regression analysis, LARS tertiles [hazard ratio (HR) 0.62, 95% confidence interval (CI) 0.44–0.86, P = 0.005] and higher degree of tricuspid regurgitation (HR 1.82, 95% CI 1.23–2.98, P = 0.003) were the only significant predictors of the primary endpoint. Importantly, DD was unavailable in 56% of patients, but LARS assessment allowed for reliable prognostication regarding the primary endpoint in subgroups without DD assessment (HR 0.64, 95% CI 0.47–0.87, P = 0.003).

Conclusion
Impaired LARS is independently associated with worse outcomes in patients undergoing TAVR. LARS allows for risk stratification at discharge even in patients where DD cannot be assessed by conventional echocardiographic means.
The effect of fibrates on lowering low-density lipoprotein cholesterol and cardiovascular risk reduction: a systemic review and meta-analysis
Authors: Kim Kyung An , Kim Na Jin , Choo Eun Ho 
Published: October 2023

Abstract

Aims
The effect of fibrate treatment on cardiovascular risk is inconsistent. This meta-analysis aimed to assess the effect of fibrates on major adverse cardiovascular outcome (MACE) reduction.

Methods and results
PubMed, Embase, and Cochrane library databases were searched up to February 2023 for randomized controlled trials comparing fibrate therapy against placebo and reporting cardiovascular outcomes and lipid profile changes. The primary outcome was the clinical outcomes of each trial that most closely corresponding to MACE, a composite of cardiovascular death, acute myocardial infarction, stroke, and coronary revascularization. A pre-specified meta-regression analysis to examine the relationship between the changes in lipid levels after fibrate treatment and the risk of MACE was also performed. Twelve trials were selected for final analysis, with 25 781 patients and 2741 MACEs in the fibrate group and 27 450 patients and 3754 MACEs in the control group. Overall, fibrate therapy was associated with decreased risk of MACE [RR 0.87, 95% confidence interval (CI) 0.81–0.94] with moderate heterogeneity (I2 = 47%). In meta-regression analysis, each 1 mmol/L reduction in low-density lipoprotein cholesterol (LDL-C) after fibrate treatment reduced MACE (RR 0.71, 95% CI 0.49–0.94, P = 0.01), while triglyceride level changes did not show a significant association (RR per 1mmol/L reduction 0.96, 95% CI 0.53–1.40, P = 0.86). A sensitivity analysis with the composite outcome of cardiovascular death or acute myocardial infarction produced similar results.

Conclusion
Treatment with fibrates was associated with decreased risk of MACE. The reduction in MACE risk with fibrate therapy appears to be attributable to LDL-C reduction rather than a decrease in triglyceride levels.
Genomic diversity of wild and cultured Yesso scallop Mizuhopecten yessoensis from Japan and Canada
Authors: Sutherland Ben J G , Itoh Naoki , Gilchrist Korrina , Boyle Brian , Roth Myron , Green Timothy J 
Published: October 2023

Abstract
The Yesso scallop Mizuhopecten yessoensis is an important aquaculture species that was introduced to Western Canada from Japan to establish an economically viable scallop farming industry. This highly fecund species has been propagated in Canadian aquaculture hatcheries for the past 40 years, raising questions about genetic diversity and genetic differences among hatchery stocks. In this study, we compare cultured Canadian and wild Japanese populations of Yesso scallop using double-digest restriction site-associated DNA (ddRAD) sequencing to genotype 21,048 variants in 71 wild-caught scallops from Japan, 65 scallops from the Vancouver Island University breeding population, and 37 scallops obtained from a commercial farm off Vancouver Island, British Columbia. The wild scallops are largely comprised of equally unrelated individuals, whereas cultured scallops are comprised of multiple families of related individuals. The polymorphism rate estimated in wild scallops was 1.7%, whereas in the cultured strains, it ranged between 1.35 and 1.07%. Interestingly, heterozygosity rates were highest in the cultured populations, which is likely due to shellfish hatchery practices of crossing divergent strains to gain benefits of heterosis and to avoid inbreeding. Evidence of founder effects and drift was observed in the cultured strains, including high genetic differentiation between cultured populations and between cultured populations and the wild population. Cultured populations had effective population sizes ranging from 9 to 26 individuals whereas the wild population was estimated at 25,048–56,291 individuals. Further, a depletion of low-frequency variants was observed in the cultured populations. These results indicate significant genetic diversity losses in cultured scallops in Canadian breeding programs.
Reduction and thermodynamic treatment of NOx emissions in a spark ignition engine using isooctane and an oxygenated fuel (ethanol)
Authors: Radhouane Meherzi , Chokri Boubahri , Jamel Bessrour 
Published: October 2023

Abstract
This research aims to study the effect of various blends of an alternative fuel environment (ethanol, isooctane) on the performance of a spark ignition gasoline engine. The blends were obtained from two additives: ethanol and isooctane. The tests were carried out on an engine test bench following DIN 70020. The results show that the petrol additives achieve excellent ecological results. On the other hand, the engine performance was slightly reduced compared with that obtained with pure fuel. We noted a variation in engine performance for the E10 (10% ethanol + 90% pure petrol) and I10 (10% isooctane + 90% pure petrol) blends, namely a reduction in nitrogen oxides (NOx) emissions of 7.5% for E10 and 5% for I10 compared with pure petrol. However, using E10 and I10 blends did not increase the specific fuel consumption. Thus, the increase in the octane rating resulted in a decrease in NOx emissions. The use of 96 octane fuels, which corresponds to I40 (40% isooctane + 60% petrol), is expected even though there is an 8% decrease in engine torque and a 5% decrease in power. We also noted that the blend (20% isooctane + 80% ethanol) led to a significant increase in NOx emissions, a significant increase in specific fuel consumption and a drop in performance (engine torque and power).
“Cultural Trauma, Populist Grand Narratives, and Brexit”
Authors: Toomey Michael , Shepherd Alistair J K 
Published: October 2023

Abstract
Recently, increased academic attention has been paid to the role played in populist rhetoric by narratives surrounding humiliation and trauma. These studies analytically focus on how populist politicians use such narratives to legitimize their messages, as a response to genuine voter demands or worries. We argue populist messaging may just as easily be constructed through a top–down, elite-driven process, rather than in response to grassroots demands. We examine the use of cultural trauma and humiliation in narratives surrounding Brexit from 2013 to the present day. We argue that these narratives, which typically tended to focus on the UK’s loss of international status during the twentieth century (and the role that membership of the EU played in this), were largely constructed by pro-Brexit members of the British political establishment and the Conservative Party. We find that these articulations served two main purposes. First, they allowed prominent Brexiteers to build a defensive wall around themselves against criticism from domestic and foreign political rivals. Secondly, they significantly raised the political significance of the process of Brexit. This allowed Brexit to be portrayed as a grand project of national rejuvenation, and its supporters as the defenders of this project. Thus, Brexit, and narratives evoking humiliation and trauma, remained central even after the country formally left the EU. Indeed, Brexit itself has become a traumatic event invoking further grand narratives that continue to draw on and create a sense of humiliation and cultural trauma, both for those who voted to leave and to remain.
The use of logic and argumentation in therapy of sex offenders
Authors: Gabbay Dov , Rozenberg Gadi , Rivlin Lydia 
Published: October 2023

Abstract
This paper is intended first for the formal argumentation community (see https://comma.csc.liv.ac.uk/). This community develops logics and systems modelling argumentation and dialogues. The community is in search of major applications areas for their models. One such application area e.g. is Law. The message of this paper is that there is another major application area for formal argumentation. There is an international community of sex offender therapist that is well established and well funded, and their therapy methods use (methods that can be modelled by) formal argumentation and logic. This community presents a natural application area for formal argumentation. We thus describe in this paper how the sex offender therapists work, to give the formal argumentation researcher a view of this application area. What is especially important about this application area is that in order to model it and learn from it, the formal argumentation community have to evolve their formal methods and adapt to this new application. Part of this enhancement is to modify and import certain methods from other areas of Logic e.g. from Non-Monotonic logic. The members of the formal argumentation community are not familiar, on average, with other areas of logic, and so we also describe in this paper, what we need from neighbouring logics. This makes this paper of interest also to sex offender therapist as well. They may be already familiar with their own practices, but the additional logics described will be of interest to them.
Aggressive sexual fantasy frequency outperforms other characteristics in cross-sectionally predicting self-reported sexual aggression in 4 samples
Authors: Bondü Rebecca 
Published: October 2023

Abstract

Background
Aggressive sexual fantasies (ASFs) have consistently been associated with sexual aggression measures. ASF frequency has mostly been used to indicate ASF, but other ASF characteristics may be important to explain the apparent gap between alleged high lifetime prevalence rates of ASF and lower sexual aggression rates—that is, why ASFs are only sometimes put into action.

Aim
The present study therefore examined whether additional ASF characteristics show associations with sexual aggression measures above and beyond ASF frequency to identify the most relevant ASF characteristics.

Methods
The present study is based on cross-sectional survey data from 4 independent mostly community samples with 448, 131, 758, and 415 participants to examine whether ASF elaboration, intrusion, preoccupation, context, and consent were associated with self-reported sexual aggression measures beyond ASF frequency.

Outcomes
Self-reported sexual aggression measures included presumably consensual and nonconsensual sexual sadism, self-reports on acting on ASF, sexual harassment, use of coercive strategies, and rape proclivity.

Results
The results showed positive correlations among all ASF characteristics. ASF frequency was the most consistent and often strongest predictor of sexual aggression across samples and outcome measures. ASF elaboration and/or its interaction with ASF frequency added to this prediction in study 1 but not in study 2. All other ASF characteristics in studies 1 to 4 either did not add to the predictions or yielded results contrary to expectations, mostly suggesting suppressor effects.

Clinical Implications
Sexual medicine and forensic sexology researchers may want to consider ASF frequency in diagnostics and develop and refine interventions to reduce it in cases of clearly elevated levels.

Strengths and Limitations
The strengths of the present study include considering 4 independent samples as well as a large number of ASF characteristics and sexual aggression measures. Its limitations include the reliance on cross-sectional data and not being able to examine the potential influences of all ASF characteristics in a single model.

Conclusion
ASF frequency seems the most valid and reliable indicator of ASF and the most important associate of sexual aggression. It should be considered the main indicator of ASF by future research and in prevention efforts and risk assessment.
Research on character tone trend clustering of Kunqu Opera based on quantum adaptive genetic algorithm
Authors: Tian Rui , Yin Ruheng , Ban Junrong 
Published: October 2023

Abstract
Kunqu, one of the oldest forms of Chinese opera, features a unique artistic expression arising from the interplay between vocal melody and the tonal quality of its lyrics. Identifying Kunqu’s character tone trend (vocal melodies derived from tonal quality of the lyrics) is critical to understanding and preserving this art form. Traditional research methods, which rely on qualitative descriptions by musicologists, have often been debated due to their subjective nature. In this study, we present a novel approach to analyze the character tone trend in Kunqu by employing computer modeling machine learning techniques. By extracting the character tone trend of Kunqu using computational modeling methods and employing machine learning techniques to apply cluster analysis on Kunqu’s character tone melody, our model uncovers musical structural patterns between singing and speech, validating and refining the qualitative findings of musicologists. Furthermore, our model can automatically assess whether a piece adheres to the rhythmic norms of ‘the integration of literature and music’ in Kunqu, thus contributing to the digitization, creation, and preservation of this important cultural heritage.
A Fast, Robust Method for Quantitative Assessment of Collagen Fibril Architecture from Transmission Electron Micrographs
Authors: Rego Bruno V , Weiss Dar , Humphrey Jay D 
Published: October 2023

AbstractCollagen is the most abundant protein in mammals; it exhibits a hierarchical organization and provides structural support to a wide range of soft tissues, including blood vessels. The architecture of collagen fibrils dictates vascular stiffness and strength, and changes therein can contribute to disease progression. While transmission electron microscopy (TEM) is routinely used to examine collagen fibrils under normal and pathological conditions, computational tools that enable fast and minimally subjective quantitative assessment remain lacking. In the present study, we describe a novel semi-automated image processing and statistical modeling pipeline for segmenting individual collagen fibrils from TEM images and quantifying key metrics of interest, including fibril cross-sectional area and aspect ratio. For validation, we show first-of-their-kind illustrative results for adventitial collagen in the thoracic aorta from three different mouse models.