bluuebunny/crossref_metadata_2025_split huggingface dataset:
Prevalence and morbidity of urogenital schistosomiasis among pre-school age children in Cubal, Angola
Authors: Sánchez-Marqués Raquel , Bocanegra Cristina , Salvador Fernando , Nindia Arlette , Pintar Zeferino , Martínez-Campreciós Joan , Aixut Sandra , Mossalilo Patricia , Sulleiro Elena , Espiau María , Mas-Coma Santiago , Bargues Ma. Dolores , Molina Israel 
Published: November 2023

Background
Schistosomiasis is one of the most important neglected tropical diseases, with a great impact on public health and more than 200,000 deaths annually. Schistosoma haematobium causes urinary tract (UT) morbidity. Since schistosomiasis morbidity control programs focus on children older than 5 years, pre-school age children (PSAC) morbidity is not well known.

Methods
We conducted a cross-sectional study in Cubal (Angola) among 245 PSAC with the objective of evaluating the prevalence of S. haematobium infection, the intensity of infection, and associated morbidity. For this purpose, urine filtration test followed by microscopic visualization and ultrasound examinations were performed.

Results
The estimated overall prevalence of urogenital schistosomiasis was 30.2% (CI 95%; 24.5–35.9), with 20.3% (CI 95%; 15.3–25.3) of the samples analysed showing a high intensity of infection. A total of 54.5% (CI 95%; 47.6–61.8) of infected children presented UT lesions, showing a significant association between schistosomiasis infection and UT morbidity (p-value < 0.001). Bladder wall thickening was the most common lesion, being present in 100% of abnormal ultrasounds. We found that anaemia and severe malnutrition were not significantly associated with the development of UT lesions.

Conclusions
S. haematobium infection in PSAC causes great UT detectable morbidities. Therefore, there is an evident need of including them in mass drug administration (MDA) campaigns and consequently the development of an adapted praziquantel treatment dosage for children under 2 years of age.
Assessing the vibration perception threshold in a community sample of adult Ghanaians
Authors: Djankpa Francis Tanam , Amoah Albert G. B. , Adzaku Festus Komla , Aidoo Eric , Boateng Isaac 
Published: November 2023

Background
The vibration perception threshold (VPT) helps evaluate human somatosensory function and diagnose peripheral neuropathy. To optimize its use as a primary neurologic tool, it is imperative to establish its typical values in healthy subjects and assess the factors affecting its variability in an individual to ensure consistency in its application.

Methods
Demographic data and a brief medical history were collected from 391 non-diabetic adults aged 30–80 at Kpone-on-Sea in Ghana. The VPT was measured at the tip of the big toe, the medial malleolus, the tip of the middle finger, and the head of the ulna of each participant using a Horwell Neurothesiometer. The variability of VPT was assessed vis-à-vis the following factors: gender, age, fasting plasma sugar and body mass index.

Results
The mean age of participants was 48.4 ± 0.7 years, and the female-to-male ratio was 1.46. The overall VPT values ranged from 5.74 ± 0.14 volts to 8.55 ± 0.18 volts in the lower limbs and 3.61 ± 0.06 volts to 5.00 ± 0.08 volts in the upper limbs. Age was found to be the only factor that could predict VPT for both the lower and upper limbs (P < 0.001). One-Way Analysis of Variance with Tukey’s posthoc showed that the VPT in the feet was significantly higher than that in the hands.

Conclusions
Generally, the VPT was high on proximal sites and low on distal sites indicating that the vibration sensation increased from proximal to distal direction. Therefore, distal areas should be used for VPT testing with a Neurothesiomer. Age was found to be the only factor that affected VPT variability. Hence, the practical application of VPT will require age-specific reference ranges to cater for older adults.
Prioritization of surgical patients during the COVID-19 pandemic and beyond: A qualitative exploration of patients’ perspectives
Authors: van Alphen Anouk M. I. A. , Sülz Sandra , Lingsma Hester F. , Baatenburg de Jong Robert J. 
Published: November 2023

Introduction
During the COVID-19 pandemic, prioritizing certain surgical patients became inevitable due to limited surgical capacity. This study aims to identify which factors patients value in priority setting, and to evaluate their perspective on a decision model for surgical prioritization.

Methods
We enacted a qualitative exploratory study and conducted semi-structured interviews with N = 15 patients. Vignettes were used as guidance. The interviews were transcribed and iteratively analyzed using thematic analysis.

Results
We unraveled three themes: 1) general attitude towards surgical prioritization: patients showed understanding for the difficult decisions to be made, but demanded greater transparency and objectivity; 2) patient-related factors that some participants considered should, or should not, influence the prioritization: age, physical functioning, cognitive functioning, behavior, waiting time, impact on survival and quality of life, emotional consequences, and resource usage; and 3) patients’ perspective on a decision model: usage of such a model for prioritization decisions is favorable if the model is simple, uses trustworthy data, and its output is supervised by physicians. The model could also be used as a communication tool to explain prioritization dilemmas to patients.

Conclusion
Support for the various factors and use of a decision model varied among patients. Therefore, it seems unrealistic to immediately incorporate these factors in decision models. Instead, this study calls for more research to identify feasible avenues and seek consensus.
Corneal epithelial remodeling induced by combined small incision lenticule extraction and accelerated corneal collagen crosslinking for myopia
Authors: Kim Kook Young , Bae Sinwoo , Lee Seongjun , Lee Yongwoo 
Published: November 2023

PurposeTo evaluate the changes of the corneal epithelial thickness (ET) profile induced by combined small incision lenticule extraction and accelerated corneal collagen crosslinking (SMILE-xtra) for myopia compared with the standard small incision lenticule extraction (SMILE).SettingNuri Eye Hospital, 61, Dunsan-ro, Seo-gu, Daejeon, 35233, Korea.DesignRetrospective cross-sectional study.MethodsThirty-one myopic eye undergoing SMILE-xtra and control group of 36 myopic eyes undergoing SMILE were retrospectively analyzed. Spectral-domain optical coherence tomography (CIRRUS™ HD-OCT 5000, ZEISS, Dublin, CA) was used to measure corneal ET of 17 zones within the central 7-mm zone at preoperative, postoperative 1 month, 3 months and 6 months. Postoperative ET alterations were analyzed for correlation with treatment parameters.ResultsThere was no difference in preoperative mean age, postoperative MRSE, visual acuity, and ablation depth between the two groups, and there was a significant difference in preoperative central corneal thickness. Both groups showed the greatest increase in corneal ET in the paracentral area on the inferotemporal area, respectively, for 6 months. The preoperative MRSE and the ablation depth showed significant correlation with the postoperative epithelial thickening in mid-peripheral sectors in both groups, and significant negative correlations in paracentral sectors only in SMILE-xtra group.ConclusionsIt is significant as the first study to compare corneal epithelial remodeling between SMILE and SMILE with accelerated corneal collagen crosslinking. The SMILE-xtra with the relatively large corneal ablation did not show a significant difference in the pattern of corneal epithelial remodeling compared to the SMILE group.
Mucosa-Associated Microbiota Dysbiosis in the Terminal Ileum Correlates With Bowel Symptoms in Diarrhea-Predominant Irritable Bowel Syndrome
Authors: Wu Bi-Yu , Xu Ping , Cheng Li , Wang Qian-Qian , Qiu Hong-Yi , Yan Xiu-Juan , Chen Sheng-Liang 
Published: November 2023

INTRODUCTION:
The mucosa-associated microbiota (MAM) is not as frequently studied in diarrhea-predominant irritable bowel syndrome (IBS-D) compared with the fecal microbiota. In this study, we examined the MAM in the terminal ileum and its correlation with bowel symptoms in IBS-D.

METHODS:
Mucosal biopsies of the terminal ileum from 25 patients with IBS-D and 25 healthy controls were collected for 16S ribosomal RNA gene sequencing. Correlation analysis was performed.

RESULTS:
Compared with healthy controls, the MAM in the terminal ileum showed a decreased alpha diversity in the IBS-D cohort (Chao1 and Shannon indexes, P < 0.05). And the overall MAM profile clustered separately into 2 groups (ADONIS [PERMANOVA, permutational multivariate analysis of variance], P < 0.05). At the phylum level, the relative abundance of Proteobacteria was significantly higher in the ileal MAM of patients with IBS-D while that of Firmicutes was significantly lower. At the genus level, the relative abundance of Pseudomonas was significantly higher in the IBS-D cohort, with lower Bacteroides and Ruminococcus. Moreover, 40.0% of patients with IBS-D had multiple small nodules (nodular lymphoid hyperplasia) on the mucosal surface of the terminal ileum, which indicated a low-grade inflammation. In patients with IBS-D with nodular lymphoid hyperplasia, the changes of Pseudomonas and Bacteroides were more overt. Correlation analysis revealed that the relative abundance of Pseudomonas positively correlated with abdominal pain and the severity of IBS.

DISCUSSION:
Patients with IBS-D showed a dysbiosis of MAM in the terminal ileum, which may be associated with bowel symptoms. Moreover, 40.0% of them displayed mucosal low-grade inflammation, with a more severe mucosal microbial disturbance.
Literature Review: Hubungan Gaya Hidup dan Pola Makan Terhadap Kejadian Hipertensi Pada Lansia di Wilayah Kerja Puskesmas
Authors: Pasaribu Clara Thalia Pionnita , Sirait Diva Radana , Siregar Ivana Yalim , Sihombing Martha Fiorella , Aini Fadilah , Rusmalawaty Rusmalawaty 
Published: November 2023

Latar Belakang: Hipertensi adalah penyakit yang mudah ditemukan di lingkungan kita yang memiliki resiko tinggi karena dapat menimbulkan komplikasi bagi penderita. Hal-hal yang berkaitan dengan tekanan darah meliputi faktor keturunan (warisan) dan gaya hidup. Penelitian ini bertujuan untuk mengetahui hubungan gaya hidup dan pola makan dengan kejadian hipertensi pada lansia.Metodologi: Artikel ini menggunakan metode seleksi berdasarkan kriteria dan kata kunci dengan hubungan gaya hidup yaitu pola makan dengan hipertensi pada lansia dan digunakan sebanyak 15 artikel yang akan dianalisis. Hasil : Berdasarkan 15 buah artikel yang dianalisis, seluruhnya menunjukkan adanya hubungan yang signifikan antara gaya hidup dan pola makan dengan kejadian hipertensi pada lansia.Simpulan: Terdapat hubungan yang signifikan antara gaya hidup yaitu pola makan dengan kejadian hipertensi pada lansia.Kata kunci: hipertensi; gaya hidup; pola makan; lansia Title: Literature Review: Correlation between Lifestyle and Diet to the Incidence of Hypertension in the Elderly in the Health Center Work AreaBackground: Hypertension is a disease that is easy to find in our environment which has a high risk because it can cause complications for sufferers. Matters related to blood pressure include heredity (inheritance) and lifestyle. This study aims to determine the relationship between lifestyle and diet and the incidence of hypertension in the elderly.Method: This article uses a selection method based on criteria and keywords with the relationship between lifestyle, namely diet and hypertension in the elderly and used as many as 15 articles to be analyzed.Results: Based on the 15 articles analyzed, all showed a significant relationship between lifestyle and diet with the incidence of hypertension in the elderly.Conclusion: There is a significant relationship between lifestyle, namely diet and the incidence of hypertension in the elderly.Keywords: hypertension; lifestyle; diet; elderly
Gambaran Cemaran Bakteri Escherichia coli pada Jajanan di SDN 70 Banda Aceh
Authors: Safira Nonie , Rahmayanti Yuni , Auliani Fia Dewi 
Published: November 2023

Latar belakang: Anak usia sekolah umumnya setiap hari menghabiskan sepertiga waktunya di sekolah, sehingga menyebabkan mereka menghabiskan waktu makan siangnya di sekolah. Adapun jenis jajanan yang dijajakan beraneka ragam dari mulai jajanan sehat maupun jajanan tidak sehat. Makanan sehat yang mempunyai gizi yang cukup, sedangkan makanan tidak sehat sudah terkontaminasi mikroba. Salah satu mikroba yang berbahaya bagi manusia pada makanan adalah bakteri Escherichia coli. Tujuan penelitian ini untuk mengetahui apakah terdapat cemaran bakteri Escherichia coli pada jajanan di SDN 70 Banda Aceh.Metode: Metode jenis penelitian ini adalah deskriptif. Penelitian ini menggunkana metode kuantitifikasi bakteri dengan Teknik MPN (Most Probable Number) dan TPC (Total Plate Count). Sampel dipilih dengan metode purposive sampling.Hasil: Hasil penelitian menunjukkan bahwa 3 sampel minuman yang diuji dengan metode MPN (Most Probable Number) melebihi batas maksimum. Sedangkan 6 sampel makanan yang diuji dengan meode TPC (Total Plate Count) dinyatakan masih dalam ambang batas.Simpulan: Hasil penelitian menunjukkan bahwa semua sampel minuman terkontaminasi bakteri Escherichia coli dan unutk makanan tidak terkontaminasi bakteri Escherichia coli.Kata kunci: jajanan sekolah, kontaminasi, Escherichia coli Title: Description of Contamination of Escherichia Coli Bacteria in Food at SDN 70 Banda AcehBackground: School-age children generally spend a third of their time at school every day, causing them to spend their lunch time at school. The types of snacks that are sold vary from healthy snacks to unhealthy snacks. Healthy food that has sufficient nutrition, while unhealthy food is contaminated with microbes. One of the microbes that are harmful to humans in food is Escherichia coli bacteria. The purpose of this study was to determine whether there was contamination of Escherichia coli bacteria in snacks at SDN 70 Banda Aceh.Method: This type of research method is descriptive. This study used a bacterial quantification method using MPN (Most Probable Number) and TPC (Total Plate Count) techniques. The sample was selected by purposive sampling method.Result: The results showed that 3 samples of drinks tested using the MPN (Most Probable Number) method exceeded the maximum limit. while 6 food samples tested with the TPC (Total Plate Count) method were declared to be still within the threshold. Conclusion: Showed that all drink samples were contaminated with Escherichia coli bacteria and food was not contaminated with Escherichia coli bacteria.Keywords: school snacks, contamination, Escherichia coli
Communication in collaborating construction equipment
Authors: Huber Adrian Josef , Fischer Anne , Schöberl Maximilian , Schock-Schmidtke Alexander , Fottner Johannes 
Published: November 2023

Abstract
Facilitating communication via standardized interfaces is key to increase construction site collaboration and productivity. This paper firstly outlines different Machine-to-Machine (M2M) messaging protocols and their suitability for communication on construction sites. Secondly, a unified construction site communication and interface solution that allows for the seamless transfer of data in M2M, Machine-to-Server (M2S), and Server-to-Server (S2S) scenarios, encompassing all layers of an Internet-of-Things (IoT) infrastructure, is proposed. The findings show that predominantly Message Queue Telemetry Transport (MQTT) is suited for M2M communication at construction sites. Underscoring the value of frequent communication and collaboration at construction sites, different exemplary use cases are presented. Additionally, interoperability at all levels of exchange as well as a unified user frontend are emphasized as key requirements to increase application rates of automated communication and collaboration within the construction industry.
Effect of laser power on microstructure and tribological behavior of laser clad NiCr coating
Authors: Chengwen Sun , Wei Li , Dejun Kong 
Published: November 2023

Abstract
NiCr coatings were prepared on H13 steel by laser cladding with different laser power. The microstructure and phases of the obtained coatings were analyzed using a super depth of field microscope and X-ray diffraction, respectively, and the effect of laser power on the friction–wear performance at high-temperature was investigated using a friction tester. The results show that the laser clad NiCr coatings fabricated at the different laser powers are composed of Cr2Ni3 and FeNi3 phases, and the porosity is decreased from 1.28 % to 0.48 % with the increase of laser power. The average coefficients of friction of NiCr coatings are decreased with the increase of laser power, and the wear rate of NiCr coating fabricated at the laser power of 1400 W power is the lowest among the three kinds of coatings, showing that the suitable laser power can improve the surface quality and wear resistance of NiCr coating.
Categorizing possession in Zuanga-Yuanga and other Kanak languages (New Caledonia): a typological perspective
Authors: Bril Isabelle 
Published: November 2023

Abstract
Like many other Oceanic and Kanak languages of New Caledonia, Zuanga-Yuanga [ZY] has classifiers restricted to the possession of nouns denoting food, drink, animals and plants; it also has dichotomous direct and indirect adnominal possessive constructions, which are generally labeled inalienable or alienable in the Oceanic literature. These terms refer to a distinction between close versus distant structural marking, which do not strictly correlate with lexical-semantic categories. For instance, kinship nouns are split over the two types of constructions, distinguishing reference from address kinship terms, not in terms of semantic distinctions between close versus distant kinship types. The split for body-part nouns is between directly possessed dedicated terms and indirectly possessed metaphorical body terms, not in terms of permanent versus removable parts, or temporary body properties. In ZY possessive constructions correlate with fairly strict possessee noun classes belonging to one single structural class (directly or indirectly marked). Only a limited number of nouns denoting parts-of-whole have alternate constructions expressing different semantic relations to the possessed noun.
Long-term prognostic value of high-sensitivity cardiac troponin-I in patients with idiopathic dilated cardiomyopathy
Authors: Wang Yongchao , Wang Xiaolin , Yang Yulin , Xu Hao , Li Jian 
Published: November 2023

Abstract
Our objective was to evaluate the long-term prognostic value of high-sensitivity cardiac troponin-I (hs-cTn-I) in idiopathic dilated cardiomyopathy (DCM). First, patients were divided into an end-event group (n = 55) and a non-end-event group (n = 67). Then, patients were included in the subgroup analysis to compare the diagnostic value of brain natriuretic peptide (BNP) and hs-cTn-I in different populations. hs-cTn-I and BNP concentrations were higher in the end-event group. The Cox regression analysis indicated that high hs-cTn-I was a risk factor for poor long-term prognosis. Receiver operating characteristic analysis showed that the area under the curve (AUC) for hs-cTn-I to predict end events was 0.751, and the AUC for BNP was 0.742. The correlation analysis suggested that hs-cTn-I was related to the percentage change in left ventricular internal diameter at end-diastolic and left ventricular ejection fraction. Subgroup analysis showed that compared with BNP, hs-cTn-I was more suitable for predicting end events in patients with preserved renal function (AUC: 0.853 vs 0.712, P = 0.04). In conclusion, hs-cTn-I is a potential biomarker for evaluating long-term prognosis in idiopathic DCM, and its predictive value is higher than that of BNP in patients with preserved renal function.
Mathematical modelling for spatial optimization of irradiation during proton radiotherapy with nanosensitizers
Authors: Kuznetsov Maxim , Kolobov Andrey 
Published: November 2023

Abstract
A spatially distributed mathematical model is presented that simulates the growth of a non-invasive tumour undergoing treatment by fractionated proton therapy with the use of non-radioactive tumour-specific nanosensitizers. Nanosensitizers are injected intravenously before each irradiation to increase the locally deposited dose via a chain of reactions with therapeutic protons. Modelling simulations show that the use of nanosensitizers allows increasing treatment efficacy. However, their effect is restricted by the necessity of decreasing the energy deposited in tumour in order to comply to the normal damage restrictions. Normalization of tumour microvasculature that accompanies the treatment, also compromises nanosensitizers effect as it impairs their inflow in tumour. It is shown that spatial optimization of irradiation, with conservation of total dose deposited in tumour, can increase tumour cell damage for each single irradiation. However, eventually it may not lead to the overall increase of treatment efficacy, in terms of minimization of the number of remaining viable tumour cells, due to the influence of tumour cell repopulation between irradiations. It is suggested that an efficient way towards minimization of tumour cell repopulation may be the faster suppression of angiogenesis by eradication of metabolically deprived tumour cells. This method can be efficient even despite the fact that it would also cause the decrease of supply of nanosensitizers into the tumour.
Dupilumab Efficacy and Safety in Severe Atopic Dermatitis in Children under 6 Years of Age: Two Clinical Cases
Authors: Murashkin Nikolay N. , Opryatin Leonid A. , Pavlova Ekaterina S. , Epishev Roman V. , Materikin Alexandr I. , Ivanov Roman A. , Savelova Alena A. , Leonova Maria A. 
Published: November 2023

Background. Atopic dermatitis (AD) manifests during the first year of life in majority of all cases. The early disease onset is associated with the development of comorbid atopic conditions within the «atopic march» phenomenon. The AD pathogenesis is associated with genetic predisposition, epidermal barrier dysfunction, and immune dysregulation. T2-inflammation specifically determines the entire immune cascade of inflammatory reactions, and, thus, dictates the need of early drug intervention to modify the disease course. Clinical case description. This article presents two clinical cases of severe AD in children under 6 years of age. The treatment of both cases included genetically engineered biologic drug dupilumab. Continuous therapy for 4–5 months made it possible to relieve the skin manifestations of the disease.Conclusion. AD, manifesting in infancy, is associated with high risk of developing other atopic spectrum diseases in older age. The timely onset of biological therapy allows us to affect immune dysregulation, and thereby to prevent the comorbid atopic conditions development.