bluuebunny/crossref_metadata_2025_split huggingface dataset:
Silicon‐Based Biomaterials Modulate the Adaptive Immune Response of T Lymphocytes to Promote Osteogenesis/Angiogenesis via Epigenetic Regulation
Authors: Xia Lunguo , Wu Tingting , Chen Lei , Mei Peng , Liu Lu , Li Ruomei , Shu Mengmeng , Huan Zhiguang , Wu Chengtie , Fang Bing 
Published: October 2023

AbstractSilicon (Si)‐based biomaterials are widely applied for bone regeneration. However, the underlying mechanisms of the materials function remain largely unknown. T lymphocyte‐mediated adaptive immune response plays a vital role in the process of bone regeneration. In the current study, mesoporous silica (MS) is used as a model material of Si‐based biomaterials. It shows that the supernatant of CD4+ T lymphocytes pretreated with MS extract significantly promotes the vascularized bone regeneration. The potential mechanism is closely related to the fact that MS extract can reduce the expression of regulatory factor X‐1 (RFX‐1) in CD4+ T lymphocytes. This may result in the overexpression of interleukin‐17A (IL‐17A) by boosting histone H3 acetylation and lowering DNA methylation and H3K9 trimethylation. Importantly, the in vivo experiments further reveal that MS particles significantly enhance bone regeneration with improved angiogenesis in the critical‐sized calvarial defect mouse model accompanied by upregulation of IL‐17A in peripheral blood and the proportion of Th17 cells. This study suggests that modulation of the adaptive immune response of T lymphocytes by silicate‐based biomaterials plays an important role for bone regeneration.
2D Bismuthine/PDMS Composite Membrane as a Potential Electrode Material for High‐Output Triboelectric Nanogenerators
Authors: Wang Minmin , Chen Qinglin , Zhao Wenwu , Tang Yanfeng 
Published: October 2023

AbstractTriboelectric nanogenerators (TENGs) with great potential in the field of energy collection and self‐powered sensing have attracted great attention. However, most of the TENGs are limited by their unsatisfactory electrical output performance and mechanical properties in utilized as wearable and flexible microelectronic devices. Herein, a flexible single‐electrode triboelectric nanogenerator composed of bismuthene (Bi‐ene) nanosheets embedded in a polydimethylsiloxane (PDMS) film is proposed. The Bi‐ene nanosheets embedded in the PDMS film act as micro‐capacitors, which enable the Bi‐ene@PDMS film to withstand high voltage and store more electrical energy. As a result, the Bi‐ene@PDMS based TENG exhibits 26 times more power density than that of the pure PDMS based TENG at the optimum Bi‐ene content. Moreover, the prepared TENG based e‐skin can meet the practical needs of power supply, motion sensing, and tactile sensing. The results can provide fundamental insights for the design of high‐performance flexible TENG.
Light and Force Multifunctional Detector Based on the Interfacial Polarization of the ITO/MAPbBr3 Schottky Junction
Authors: Ding Yecheng , Zhao Xuefeng , Zhao Zeen , Yan Zhibo , Yuan Guoliang , Liu Jun‐Ming 
Published: October 2023

AbstractThe MAPbBr3 halide perovskite with a cubic paraelectric phase exhibits excellent semiconductor properties. Here, an interfacial polarization (Pin) at the ITO/MAPbBr3 Schottky junction can largely enhance photovoltaic current and be applied in the light and force multifunctional detector. An external force can alter the Pin and increase the photocurrent of the ITO/MAPbBr3/spiro‐OMeTAD/ITO detector, and a 1 N force increases the short‐circuit photocurrent by 120%. Furthermore, the ITO/MAPbBr3/ITO structure with one ITO surface in light and another ITO surface in dark exhibits an equivalent piezoelectric coefficient (d33) of up to 83 pC N−1 since the Pin and the corresponding photovoltaic current dynamically change with periodic external force. The light and force multifunctional detectors will promote the development and blend of optoelectronic devices and MEMS.
Microneedles Loaded with Dexamethasone and Epigallocatechin‐3‐gallate Reverse the Imbalance of Subcutaneous Immune Homeostasis for the Treatment of Psoriasis
Authors: Jia Honglin , Yang Qi , Hong Jiahui , Ding Rui , Liu Tao , Yang Qunfang , Zheng Haiping , Huang Qingshan , Zhang Zhaowei , Chen Xiaohong , Sun Renshan , Yu Yunlong , Shan Wenjun 
Published: October 2023

AbstractMaintaining the homeostasis of the skin's immune microenvironment is crucial for skin's health. In inflammatory skin conditions (like psoriasis), the immune microenvironment is dysregulated, including reactive oxygen species (ROS) accumulation and T cell overactivation. In addition to promoting inflammation and excessive keratinocyte proliferation, ROS upregulation in psoriasis also induces glucocorticoid resistance, which poses a significant challenge to the effectiveness of glucocorticoid treatment (e.g., dexamethasone, Dex) in psoriasis. To conquer this problem, epigallocatechin‐3‐gallate (EGCG) is used to eliminate ROS production in psoriasis. Application of EGCG reduces ROS levels and improves the antipsoriasis effect of Dex in vitro. Benefiting from the unique characteristics of microneedle (MN) for transdermal drug delivery, a dissolvable MN patch containing EGCG and Dex (DEX/EGCG‐MN) is constructed, which can directly codelivery the two elements to the lesion area without stratum corneum barrier. The MN alleviates psoriasis‐like manifestations in imiquimod‐induced psoriasis mouse model, indicated by epidermal thickness and dorsal skin signs. Besides, DEX/EGCG‐MN corrects the disorder of immune cells, including innate and acquired immune cells. As a result, it mediates the balance in the skin's immune microenvironment. Meanwhile, the MN also ameliorates the hyperproliferation of keratinocytes in psoriatic lesions. It is believed that this approach may offer insights for further developing antipsoriasis assays.
Ferroelectricity in Epitaxial Tetragonal ZrO2Thin Films
Authors: El Boutaybi Ali , Maroutian Thomas , Largeau Ludovic , Findling Nathaniel , Brubach Jean‐Blaise , Cervasio Rebecca , Degezelle Alban , Matzen Sylvia , Vivien Laurent , Roy Pascale , Karamanis Panagiotis , Rérat Michel , Lecoeur Philippe 
Published: October 2023

AbstractThe crystal structure and ferroelectric properties of epitaxial ZrO2films ranging from 7 to 42 nm thickness grown on La0.67Sr0.33MnO3buffered (110)‐oriented SrTiO3substrate are reported. By employing X‐ray diffraction, a tetragonal phase (t‐phase) at all investigated thicknesses, with slight in‐plane strain due to the substrate in the thinnest films, is confirmed. Further confirmation of the t‐phase is obtained through infrared absorption spectroscopy with synchrotron light, performed on ZrO2membrane transferred onto a high resistive silicon substrate. Up to a thickness of 31 nm, the ZrO2epitaxial films exhibit ferroelectric behavior, at variance with the antiferroelectric behavior reported previously for the t‐phase in polycrystalline films. However, the ferroelectricity is found here to diminish with increasing film thickness, with a polarization of 13 µC cm−2and down to 1 µC cm−2for 7 and 31 nm thick ZrO2films, respectively. Given that the t‐phase is nonpolar, the observations emphasize the influence of external factors, in promoting polarization in t‐ZrO2thin films. These findings provide new insights into the ferroelectric properties and structure of ZrO2thin films, and open up new directions to investigate the origin of ferroelectricity in ZrO2and to optimize this material for future applications.
Nuclear and chloroplast DNA phylogeography reveals high genetic diversity and postglacial range expansion in Quercus mexicana
Authors: Sánchez‐Acevedo Vanessa , González‐Rodríguez Antonio , Torres‐Miranda César Andrés , Rodríguez‐Correa Hernando , Valencia‐Á. Susana , De‐la‐Cruz Ivan M. , Oyama Ken 
Published: October 2023

AbstractPremisePhylogeographical studies are fundamental for understanding factors that influence the spatial distribution of genetic lineages within species. Population expansions and contractions, distribution shifts, and climate changes are among the most important factors shaping the genetic compositions of populations.MethodsWe investigated the phylogeography of an endemic oak, Quercus mexicana (Fagaceae), which has a restricted distribution in northeastern Mexico along the Sierra Madre Oriental and adjacent areas. Nuclear and chloroplast DNA microsatellite markers were used to describe the genetic diversity and structure of 39 populations of Q. mexicana along its entire distribution area. We tested whether population expansion or contraction events influenced the genetic diversity and structure of the species. We also modeled the historical distributional range of Q. mexicana (for the Mid Holocene, the Last Glacial Maximum, and the Last Interglacial) to estimate the extent to which climate fluctuations have impacted the distribution of this oak species.ResultsOur results revealed high genetic diversity and low genetic structure in Q. mexicana populations. Ecological niche models suggested historical fluctuations in the distributional range of Q. mexicana. Historical range changes, gene flow, and physical barriers seem to have played an important role in shaping the phylogeographic structure of Q. mexicana.ConclusionsOur study indicates that the genetic structure of Q. mexicana may have been the result of responses of oak trees not only to heterogeneous environments present in the Sierra Madre Oriental and adjacent areas, but also to elevational and latitudinal shifts in response to climate changes in the past.
EED related overgrowth: First report of multiple members in a single family
Authors: Goel Himanshu , O'Donnell Sheridan , Edwards Matthew 
Published: October 2023

AbstractEED is a core component of polycomb repressive complex 2 (PRC2) with EZH2 and SUZ12. PRC2 has H3K27 methyltransferase activity (HMTase) that catalyzes the addition of up to three methyl groups on histone 3 at lysine residue 27 (H3K27). Germline heterozygous variants in EED, SUZ12, and EZH2 have been identified in patients with overgrowth and multiple dysmorphic features. The clinical manifestations of these syndromes significantly overlap: generalized overgrowth, intellectual disability, and scoliosis. To date, 11 unrelated patients have been published with missense variants in EED at highly conserved amino acids. We report three affected members in a family with a previously reported missense variant. All three affected members manifested very similarly, and this represents a homogenous clinical phenotype associated with EED related intellectual disability and overgrowth. This disorder is appropriately called Cohen‐Gibson syndrome.
Impacts of climate change and habitat loss on the distribution of the endangered crested capuchin monkey (Sapajus robustus)
Authors: Heming Neander M. , Mota Flavio M. M. , Talora Daniela C. , Martins Waldney P. 
Published: October 2023

AbstractThe crested capuchin monkey (Sapajus robustus) is endemic to the Atlantic Forest and its transition areas within Cerrado in Brazil. The species is currently threatened by habitat loss and has been classified as endangered by the IUCN Red List of Threatened Species since 2015. We used ecological niche models built with MaxEnt to predict the potential impact of climate change on the distribution of this species. The models were projected onto the reference climate, considering six climate scenarios (three Global Climate Models and two Representative Concentration Pathways) from IPCC for 2050 and 2070. We showed that while the amount of suitable area is expected to change little across the species' range in most evaluated climate scenarios, climatic conditions may significantly deteriorate by 2070 in the pessimistic scenario, especially in currently warmer and dryer areas to the west. As seen on other capuchin monkeys, the potential use of tools by crested capuchins may increase the chances of the species adaptation to novel harsher environmental conditions. The major negative impacts across the species range also include habitat loss and fragmentation so that the conservation of the species relies on the protection of the forest remnants in the center of its distribution, which can harbor populations of the species in current and future climate scenarios.
Artificial intelligence for dementia prevention
Authors: Newby Danielle , Orgeta Vasiliki , Marshall Charles R. , Lourida Ilianna , Albertyn Christopher P. , Tamburin Stefano , Raymont Vanessa , Veldsman Michele , Koychev Ivan , Bauermeister Sarah , Weisman David , Foote Isabelle F. , Bucholc Magda , Leist Anja K. , Tang Eugene Y. H. , Tai Xin You ,   The Deep Dementia Phenotyping (DEMON) Network, Llewellyn David J. , Ranson Janice M. 
Published: October 2023

AbstractINTRODUCTIONA wide range of modifiable risk factors for dementia have been identified. Considerable debate remains about these risk factors, possible interactions between them or with genetic risk, and causality, and how they can help in clinical trial recruitment and drug development. Artificial intelligence (AI) and machine learning (ML) may refine understanding.METHODSML approaches are being developed in dementia prevention. We discuss exemplar uses and evaluate the current applications and limitations in the dementia prevention field.RESULTSRisk‐profiling tools may help identify high‐risk populations for clinical trials; however, their performance needs improvement. New risk‐profiling and trial‐recruitment tools underpinned by ML models may be effective in reducing costs and improving future trials. ML can inform drug‐repurposing efforts and prioritization of disease‐modifying therapeutics.DISCUSSIONML is not yet widely used but has considerable potential to enhance precision in dementia prevention.Highlights
Artificial intelligence (AI) is not widely used in the dementia prevention field.
Risk‐profiling tools are not used in clinical practice.
Causal insights are needed to understand risk factors over the lifespan.
AI will help personalize risk‐management tools for dementia prevention.
AI could target specific patient groups that will benefit most for clinical trials.
Clean Synthetic Strategies to Biologically Active Molecules from Lignin: A Green Path to Drug Discovery**
Authors: Afanasenko Anastasiia M. , Wu Xianyuan , De Santi Alessandra , Elgaher Walid A. M. , Kany Andreas M. , Shafiei Roya , Schulze Marie‐Sophie , Schulz Thomas F. , Haupenthal Jörg , Hirsch Anna K. H. , Barta Katalin 
Published: October 2023

AbstractDeriving active pharmaceutical agents from renewable resources is crucial to increasing the economic feasibility of modern biorefineries and promises to alleviate critical supply‐chain dependencies in pharma manufacturing. Our multidisciplinary approach combines research in lignin‐first biorefining, sustainable catalysis, and alternative solvents with bioactivity screening, an in vivo efficacy study, and a structural‐similarity search. The resulting sustainable path to novel anti‐infective, anti‐inflammatory, and anticancer molecules enabled the rapid identification of frontrunners for key therapeutic indications, including an anti‐infective against the priority pathogen Streptococcus pneumoniae with efficacy in vivo and promising plasma and metabolic stability. Our catalytic methods provided straightforward access, inspired by the innate structural features of lignin, to synthetically challenging biologically active molecules with the core structure of dopamine, namely, tetrahydroisoquinolines, quinazolinones, 3‐arylindoles and the natural product tetrahydropapaveroline. Our diverse array of atom‐economic transformations produces only harmless side products and uses benign reaction media, such as tunable deep eutectic solvents for modulating reactivity in challenging cyclization steps.
Supra‐Cyanines: Ultrabright Cyanine‐Based Fluorescent Supramolecular Materials in Solution and in the Solid State
Authors: Lu Haicheng , Wang Yuqian , Hill Sophie K. , Jiang Hanqiu , Ke Yubin , Huang Shaohui , Zheng Dunjin , Perrier Sébastien , Song Qiao 
Published: October 2023

AbstractFluorescent materials with high brightness play a crucial role in the advancement of various technologies such as bioimaging, photonics, and OLEDs. While significant efforts are dedicated to designing new organic dyes with improved performance, enhancing the brightness of existing dyes holds equal importance. In this study, we present a simple supramolecular strategy to develop ultrabright cyanine‐based fluorescent materials by addressing long‐standing challenges associated with cyanine dyes, including undesired cis‐trans photoisomerization and aggregation‐caused quenching. Supra‐cyanines are obtained by incorporating cyanine moieties in a cyclic peptide‐based supramolecular scaffold, and exhibit high fluorescence quantum yields (up to 50 %) in both solution and in the solid state. These findings offer a versatile approach for constructing highly emissive cyanine‐based supramolecular materials.
Densely Packed CO2 Aids Charge, Spin, and Lattice Ordering Partially Fluctuated in a Porous Metal–Organic Framework Magnet
Authors: Kosaka Wataru , Hiwatashi Yoshie , Amamizu Naoka , Kitagawa Yasutaka , Zhang Jun , Miyasaka Hitoshi 
Published: October 2023

AbstractPartial charge fluctuations in the charge‐ordered state of a material, often triggered by structural disorders and/or defects, can significantly alter its physical characteristics, such as magnetic long‐range ordering. However, it is difficult to post‐chemically fix such accidental partial fluctuations to reconstruct a uniform charge‐ordered state. Herein, we report CO2‐aided charge ordering demonstrated in a CO2‐post‐captured layered magnet, [{Ru2(o‐ClPhCO2)4}2{TCNQ(OMe)2}] ⋅ CO2 (1⊃CO2; o‐ClPhCO2−=ortho‐chlorobenzoate; TNCQ(OMe)2=2,5‐dimethoxy‐7,7,8,8‐tetracyanoquinodimethane). Pristine porous layered magnet 1 had a partially charge‐fluctuated ordered state, which provided ferrimagnetic ordering at TC=65 K. Upon loading CO2, 1 adsorbed one mole of CO2, forming 1⊃CO2, and raising TC to 100 K. This was because of the vanishing charge fluctuations without significantly changing the framework structure. This research illustrates the post‐accessible host–guest chemistry delicately combined with charge, spin, and lattice ordering in a spongy magnet. Furthermore, it highlights how this innovative approach opens up new possibilities for technology and nanoscale magnetism manipulation.
Guaiacol as an Organic Superoxide Dismutase Mimics for Anti‐ageing a Ru‐based Li‐rich Layered Oxide Cathode
Authors: Lee Jeongin , Kim Min‐Ho , Lee Hosik , Kim Jonghak , Seo Jeongwoo , Lee Hyun‐Wook , Hwang Chihyun , Song Hyun‐Kon 
Published: October 2023

AbstractHigh‐capacity Li‐rich layered oxides using oxygen redox as well as transition metal redox suffer from its structural instability due to lattice oxygen escaped from its structure during oxygen redox and the following electrolyte decomposition by the reactive oxygen species. Herein, we rescued a Li‐rich layered oxide based on 4d transition metal by employing an organic superoxide dismutase mimics as a homogeneous electrolyte additive. Guaiacol scavenged superoxide radicals via dismutation or disproportionation to convert two superoxide molecules to peroxide and dioxygen after absorbing lithium superoxide on its partially negative oxygen of methoxy and hydroxyl groups. Additionally, guaiacol was decomposed to form a thin and stable cathode‐electrolyte interphase (CEI) layer, endowing the cathode with the interfacial stability.
Ag+‐Doped InSe Nanosheets for Membrane Electrode Assembly Electrolyzer toward Large‐Current Electroreduction of CO2to Ethanol
Authors: Wang Xiangyu , Jiang Zhiwei , Wang Peng , Chen Zheng , Sheng Tian , Wu Zhengcui , Xiong Yujie 
Published: October 2023

AbstractIt is an appealing approach to CO2utilization through CO2electroreduction (CO2ER) to ethanol at high current density; however, the commonly used Cu‐based catalysts cannot sustain large current during CO2ER despite their capability for ethanol production. Herein, we report that Ag+‐doped InSe nanosheets with Se vacancies can address this grand challenge in a membrane electrode assembly (MEA) electrolyzer. As revealed by our experimental characterization and theoretical calculation, the Ag+doping, which can tailor the electronic structure of InSe while diversifying catalytically active sites, enables the formation of key reaction intermediates and their sequential evolution into ethanol. More importantly, such a material can well work for large‐current conditions in MEA electrolyzers with In2+species stabilized via electron transfer from Ag to Se. Remarkably, in an MEA electrolyzer by coupling cathodic CO2ER with anodic oxygen evolution reaction (OER), the optimal catalyst exhibits an ethanol Faradaic efficiency of 68.7 % and a partial current density of 186.6 mA cm−2on the cathode with a full‐cell ethanol energy efficiency of 26.1 % at 3.0 V. This work opens an avenue for large‐current production of ethanol from CO2with high selectivity and energy efficiency by rationally designing electrocatalysts.
Recent Advances in the Development of Non‐Invasive Imaging Probes for Cancer Immunotherapy
Authors: Kazim Muhammad , Yoo Euna 
Published: October 2023

AbstractThe last two decades have witnessed a major revolution in the field of tumor immunology including clinical progress using various immunotherapy strategies. These advances have highlighted the potential for approaches that harness the power of the immune system to fight against cancer. While cancer immunotherapies have shown significant clinical successes, patient responses vary widely due to the complex and heterogeneous nature of tumors and immune responses, calling for reliable biomarkers and therapeutic strategies to maximize the benefits of immunotherapy. Especially, stratifying responding individuals from non‐responders during the early stages of treatment could help avoid long‐term damage and tailor personalized treatments. In efforts to develop non‐invasive means for accurately evaluating and predicting tumor response to immunotherapy, multiple affinity‐based agents targeting immune cell markers and checkpoint molecules have been developed and advanced to clinical trials. In addition, researchers have recently turned their attention to substrate and activity‐based imaging probes that can provide real‐time, functional assessment of immune response to treatment. Here, we highlight some of those recently designed probes that image functional proteases as biomarkers of cancer immunotherapy with a focus on their chemical design and detection modalities and discuss challenges and opportunities for the development of imaging tools utilized in cancer immunotherapy.