bluuebunny/crossref_metadata_2025_split huggingface dataset:
Unveiling the role of MGMT and DAPK hypermethylation in response to anti‐EGFR agents: Molecular insights for advancing HNSCC treatment
Authors: Arantes Lidia Maria Rebolho Batista , Silva‐Oliveira Renato José , de Carvalho Ana Carolina , Melendez Matias Eliseo , Sorroche Bruna Pereira , de Jesus Teixeira Renan , Tostes Katiane , Palmero Edenir Inez , Reis Rui Manuel , Carvalho André Lopes 
Published: December 2023

AbstractBackgroundEpidermal growth factor receptor (EGFR) is frequently activated in head and neck squamous cell carcinoma (HNSCC) and serves as a valuable target for therapy. Despite the availability of the EGFR inhibitors Cetuximab, Afatinib, and Allitinib, there are limited predictive markers for their response. Understanding molecular aberrations in HNSCC could facilitate the identification of new strategies for patient clinical and biological classification, offering novel therapeutic avenues.MethodsWe assessed CCNA1, DCC, MGMT, CDKN2A/p16, and DAPK methylation status in HNSCC cell lines and their association with anti‐EGFR treatment response.ResultsMGMT methylation status displayed high sensitivity and specificity in distinguishing sensitive and resistant HNSCC cell lines to Afatinib (AUC = 0.955) and Allitinib (AUC = 0.935). Moreover, DAPK methylation status predicted response to Allitinib with high accuracy (AUC = 0.852), indicating their putative predictive biomarker roles.ConclusionThese findings hold promise for the development of more personalized and effective treatment approaches for HNSCC patients.
The medial prefrontal cortex during flexible decisions: Evidence for its role in distinct working memory processes
Authors: Kidder Kevan , Gillis Ryan , Miles Jesse , Mizumori Sheri J. Y. 
Published: December 2023

AbstractDuring decisions that involve working memory, task‐related information must be encoded, maintained across delays, and retrieved. Few studies have attempted to causally disambiguate how different brain structures contribute to each of these components of working memory. In the present study, we used transient optogenetic disruptions of rat medial prefrontal cortex (mPFC) during a serial spatial reversal learning (SSRL) task to test its role in these specific working memory processes. By analyzing numerous performance metrics, we found: (1) mPFC disruption impaired performance during only the choice epoch of initial discrimination learning of the SSRL task; (2) mPFC disruption impaired performance in dissociable ways across all task epochs (delay, choice, return) during flexible decision‐making; (3) mPFC disruption resulted in a reduction of the typical vicarious‐trial‐and‐error rate modulation that was related to changes in task demands. Taken together, these findings suggest that the mPFC plays an outsized role in working memory retrieval, becomes involved in encoding and maintenance when recent memories conflict with task demands, and enables animals to flexibly utilize working memory to update behavior as environments change.
Barrier and channel thickness engineering to optimize fin height for enhancement mode Al0.3Ga0.7N/GaN FinHEMT
Authors: Chakrabarty A. , Swain R. , Sahoo N. , Jena K. , Panigrahy A. K. , Lenka T. R. 
Published: December 2023

AbstractIn this work, a thorough analysis of the Al0.3Ga0.7N/GaN FinHEMT structure has been performed using three‐dimensional numerical simulations to achieve enhancement mode (E‐mode) operation. In the proposed optimized structure, the fin height (HFin) is comprised of 7 nm critical strained AlGaN barrier layer with 30% Al mole fraction and 63 nm GaN channel layer having a fixed fin width (WFin) of 160 nm. The two‐dimensional electron gas (2DEG) concentration near the hetero interface is found to vary inversely with HFin of the proposed structure. The 2DEG variation was compared between fin‐shaped full tri‐gate approach and variable side gate length tri‐gate design counterpart for a fixed HFin of 70 nm. We achieved an improved threshold voltage of −0.2 V in the optimized HFin structure as compared to −1.45 V obtained in the unoptimized structure as reported earlier. Further, upon decreasing WFin to 40 nm in the same structure having optimized HFin of 70 nm, an E‐mode operation was achieved with a positive threshold voltage of 0.4 V. The positive shift in threshold voltage is explained with the help of necessary energy band diagram.
Assessment of NA‐CORDEX regional climate models, reanalysis and in situ gridded‐observational data sets against the U.S. Climate Reference Network
Authors: SY Souleymane , Madonna Fabio , Serva Federico , Diallo Ismaila , Quesada Benjamin 
Published: December 2023

AbstractClimate models' capability of reproducing the present climate at both global and regional scales still needs improvements. The assessment of model performance critically depends on the data sets used as comparators/references. Reanalysis and gridded observational data sets have been frequently used for this purpose. However, none of these can be considered an accurate reference data set because of their associated uncertainties and full representativity. This paper, for the first time, uses in‐situ measurements from National Oceanic and Atmospheric Administration U.S. Climate Reference Network (USCRN) spanning the period 2006–2020 to assess daily temperature and precipitation from a suite of dynamically downscaled regional climate models (RCMs; driven by ERA‐Interim) involved in NA‐CORDEX. The assessment is also extended to the most recent and widely used Earth system reanalyses (ERA5, ERA‐Interim, MERRA2 and NARR) and a few in situ‐based gridded data sets (Daymet, PRISM, Livneh and CPC). Results show that biases for the different data sets are seasonally and subregionally dependent. On average, reanalysis and in situ‐based gridded data sets are warmer (with biases exceeding 0.3°C) than USCRN year‐round, while RCMs are colder (warmer) in winter (summer) with biases ranging from −0.5 (0.9)°C for RCMs at 0.44° to −0.2 (1.4)°C for CRCM5‐UQAM‐11. In situ‐based gridded data sets provide the best performance in most of the Contiguous United States (CONUS) regions compared to reanalyses and RCMs, but still have biases in regions such as the Western mountains and the Pacific Northwest. Furthermore, in most US subregions, reanalysis data sets do not outperform reanalysis‐driven RCMs. Likewise, for both reanalysis data sets and RCMs, temperature and precipitation biases vary considerably depending on the local orography, with larger temperature biases for coarser model resolutions and precipitation biases for reanalysis.
Endoscopic treatment of subglottic stenosis with flexible bronchoscopy via laryngeal mask airway
Authors: Gallagher Liam , Todatry Soorya , Oldenburg Kirsi , Misono Stephanie , Gray Raluca 
Published: December 2023

ObjectiveTo evaluate the safety and efficacy of endoscopic treatment of subglottic stenosis with flexible bronchoscopy via laryngeal mask airway (LMA) approach.MethodsThe records of all patients who underwent endoscopic surgery for subglottic stenosis (SGS) from November 2019 to January 2023 at an academic medical center were reviewed with attention to demographics, patient comorbidities, airway stenosis characteristics, operative time details, surgical complications, and post‐operative course. All patients, >18 years old, with one or more surgeries for SGS using (LMA) for intraoperative airway management were included. Surgeries with suspension microlaryngoscopy were excluded. Patients with glottic stenosis or tracheotomy were excluded.ResultsThirty‐five patients underwent 52 procedures meeting inclusion criteria. Mean age was 55 years (range 31–78, SD 13.3) and 33 patients (94%) were female. Mean BMI was 30.9 (range 18.4–60.5, SD 8.8). The most common etiology of stenosis was intubation injury in 17 patients (49%), followed by idiopathic in 13 patients (37%). Cotton‐Meyer grade 3 (71–99% narrowing) was seen in 25 patients (71%). Mean anesthesia and surgical operative times were 75.9 min (SD 13.5 min) and 39.7 min (SD 11.0 min), respectively. Mean SpO2 nadir was 94.5% (SD 6.3%). No patients required intraoperative change to rigid laryngoscopy, intubation, or tracheotomy. There were no post‐operative complications. Mean surgery‐free interval was 12.2 months (SD 6.3).ConclusionEndoscopic treatment of subglottic stenosis with flexible bronchoscopy and spontaneous ventilation via LMA approach is a safe and effective option, especially in patients with limitations for rigid laryngoscopy and elevated BMI.Level of EvidenceLevel Four (case series) Laryngoscope, 134:2672–2677, 2024
Elevated FVIII levels in hereditary hemorrhagic telangiectasia: Implications for clinical management
Authors: Jørgensen Ole Jakob , Steineger Johan Edvard , Hillarp Andreas , Pareli Wåland Erik , Holme Pål André , Heimdal Ketil , Dheyauldeen Sinan 
Published: December 2023

AbstractObjectivesThe objective of this study was twofold: to determine the prevalence of arterial and venous thromboembolic events in the Norwegian Hereditary Hemorrhagic Telangiectasia (HHT) population, and to explore potential factors linked to such events, with particular emphasis on FVIII.MethodsPatients with an HHT diagnosis attending the Otorhinolaryngology Department at Oslo University Hospital—Rikshospitalet were included consecutively between April 2021 and November 2022. We recorded the participants' medical history with an emphasis on thromboembolic events. Measurements of blood constituents, including FVIII, FIX, vWF, hemoglobin, iron, ferritin, and CRP were performed.ResultsOne hundred and thirty‐four patients were included in the study. The total prevalence of thromboembolic events among the participants was 23.1%. FVIII levels were high (>150 IU/dL) in the majority of HHT patients (n = 84) (68.3%) and were significantly associated with thromboembolic events (p < .001), as was age. Of the patients with high FVIII levels, 28 (33%) had experienced a thromboembolic event. Furthermore, FVIII levels were measured consecutively in 51 patients and were found to fluctuate above or below 150 IU/dL in 25% of these cases.ConclusionThromboembolic events are highly prevalent in the Norwegian HHT population and are significantly associated with FVIII levels. FVIII levels can fluctuate, and measurements should be repeated in HHT patients to assess the risk of thromboembolic events.Level of Evidence4.
Recruitment of older adults from long‐term care settings for a longitudinal clinical trial
Authors: Davis Rebecca , Sikorskii Alla 
Published: December 2023

AbstractRecruitment of residents for research from long‐term care settings is known to be difficult. The purpose of this study was to summarize the effectiveness and cost in terms of time and dollars of recruitment methods for a cluster‐randomized controlled clinical trial conducted in long‐term care settings. This study was a retrospective, exploratory, descriptive analysis of recruitment data. After recruitment of 15 independent and assisted living communities, residents at each site were recruited to participate in the study using combinations of 12 different recruitment methods. Recruitment methods, time spent screening, and enrollment data were collected. Recruitment data were analyzed at the levels of site, research staff member, and participant. Over the study period, 279 older adults were screened and 172 enrolled from the 15 sites. Many participants were cognitively impaired. Research staff spent 39–89 h recruiting at each site and utilized an average of four different recruitment methods per site. Introductions of participants by site contacts yielded the most consented participants compared to other recruitment methods. Sites that had a dedicated recruiter utilized more recruiting methods and enrolled more participants than those without a dedicated recruiter. The cost of recruiting averaged $1490 per site and $93–$258 per enrollee (mean $144, standard deviation $58), but was more costly in larger facilities. Recruitment of older adults from long‐term care communities requires multiple methods of recruitment, skilled recruitment staff, and trust with the staff and potential participants.
Prevalence and determinants of postpartum depression among adolescent and adult mothers in Northwest Ethiopia
Authors: Kassa Getachew , Batchelder Anne , Gross Deborah 
Published: December 2023

AbstractPostpartum depression (PPD) is a common mental health issue in resource‐limited settings that negatively affects the well‐being of mothers and children. However, PPD often remains untreated, leading to long‐term consequences for families. Therefore, we examined the prevalence and determinants of PPD among adolescent and adult mothers in northwest Ethiopia. Data were collected from 374 adolescent (10–19 years) and 760 adult (20–34 years) mothers 6 weeks after childbirth. Data were analyzed using binary and multiple logistic regression. Adolescent mothers had a significantly higher proportion of PPD (37.4%) than adult mothers (20.1%) and were more likely to report low self‐esteem (13.1% vs. 8.2%) and low social support (28.3% vs. 23.3%). Factors associated with PPD differed between adolescent and adult mothers. Adolescent mothers with PPD were more likely to report household food insecurity, low self‐esteem, low knowledge of postpartum complications, and working in agriculture or professional/technical occupations. For adult mothers, factors associated with PPD included distance to the nearest health facility, medium social support, inadequate dietary diversity, and food insecurity. Results suggest that targeted interventions by age group are needed to reduce the burden of PPD in Ethiopia.
Stability control of a two‐lane car‐following model based on cluster synchronization of complex network
Authors: Du Wenju , Li Yinzhen , Zhang Jiangang 
Published: December 2023

AbstractThe article investigated the stability of a two‐lane car‐following model with lateral friction on the basis of cluster synchronization theory of complex network. By using the Lyapunov stability theory and designing the appropriate controller, the two‐lane car‐following model with lateral friction is quickly stabilized and the stability condition of the model is obtained. Besides, based on the adaptive cluster synchronization theory for complex networks with external disturbances, the stability of two‐lane car‐following model with lateral friction is studied when the vehicles is subjected to random external disturbance. Finally, the numerical simulation is carried out by using Matlab simulation technology, the results show that the two‐lane car‐following model with lateral friction is rapidly stabilizing and congestion phenomenon is effectively alleviated under the controller designed.
Mass spectrometry approaches to natural and synthetic melanin characterization
Authors: Keating Addie R. , Dhinojwala Ali , Wesdemiotis Chrys 
Published: December 2023

AbstractCharacterization of synthetic and natural melanin nanoparticles (MNPs) has been challenging due to the variability of properties and chemical bonding. Although eumelanin was the first to be discovered, four additional subcategories of melanin now exist including pheomelanin, neuromelanin, allomelanin and pyomelanin. Mass spectrometry (MS) methods have provided crucial insights into the bonding, structure, and mechanism regarding MNP formation, but inconsistent findings in the literature have caused further confusion in the analysis and structure of MNPs. This mini‐review will focus on the types of MS experiments that have been used to analyze MNPs and what kind of information can be gained from different ionization sources, collisional activation experiments, and reaction monitoring quantitative methods when analyzing different subcategories of MNPs. Additionally, future directions regarding alternative applications of MNPs in MS experiments, mass defect analyses of complex mixtures, and a standardized nomenclature for isomeric redox states will all be addressed. © 2023 The Authors. Polymer International published by John Wiley & Sons Ltd on behalf of Society of Industrial Chemistry.
Material availability assessment using system dynamics: The case of tellurium
Authors: Hanna Francis , Nain Preeti , Anctil Annick 
Published: December 2023

AbstractWith the increased deployment of solar photovoltaic (PV), the cadmium telluride (CdTe) PV market is expected to grow substantially. CdTe PV production is crucial for the clean energy transition but problematic because of the material availability challenges. CdTe PV relies on tellurium, a scarce metal mainly produced as a byproduct of copper. Several studies investigated the availability of tellurium for CdTe PV. However, previous models are static and do not reflect the interconnection between tellurium supply, demand, and price. Despite the efforts, previous studies have inconsistent results and do not provide a clear understanding on the availability of tellurium for CdTe PV applications. This study uses system dynamics modeling to assess tellurium availability between 2023 and 2050. The model considers different scenarios for CdTe PV demand growth and PV material intensity reduction. The model also considers tellurium supply variables such as Te‐rich ores, tellurium yield from anode slimes, and growth in copper mining. The historical data (2000–2020) analysis shows a negative correlation between the tellurium price and the annual tellurium surplus. All the considered demand scenarios exhibit a tellurium supply gap where annual material production falls below demand. Tellurium availability and price could delay the growth of CdTe PV production, and maintaining the current CdTe PV market share of ~4% will be challenging. The low‐demand scenario, which is based on a constant CdTe PV market share, results in a supply gap starting in 2029 and a supply gap peak of 508 metric tons in 2036. Our work shows that having more manufacturing capacity is insufficient if tellurium is unavailable. More importantly, this work shows that fast growth in CdTe PV production can diminish the advantages of dematerialization. The estimated cumulative CdTe PV production by 2050 ranges between 929 and 2250 GWp. The findings also suggest that recycling retired solar panels can contribute to 17% of the total tellurium demand and 34% of the CdTe PV tellurium demand. Sensitivity analysis shows that expanding existing Te‐rich ores does not alleviate tellurium scarcity. Alternatively, improving tellurium yield from copper electrorefining is a more efficient mitigation approach. The system dynamic approach outlined in this study provides a better perspective on the status of various critical metal supply chains, ultimately leading to sustainable materials management and increasing CdTe production.
Study on the safety and mechanical properties of a new tetrazole‐based energetic material
Authors: Zhang Liang‐Liang , Du Qi‐Xuan , Zhang Lu , Ye Zhi‐Wen , Qian Hua 
Published: December 2023

AbstractDTDA‐THA (tris(hydrazin‐1‐ium)5,5′‐(hydrazin‐1‐ide‐1,2‐diylbis((1H‐tetrazole‐5,1‐diyl)))bis(tetrazol‐2‐ide)) is a novel type of poly‐nitrogen energetic material characterized by high nitrogen content, high enthalpy of formation, and low sensitivity. To research the application of DTDA‐THA in polymer‐bonded explosives (PBXs) and improve the safety performance of DTDA‐THA in composite explosives, this study calculated the binding energies between ethylene‐vinyl acetate copolymer (EVA), polyvinyl butyral (PVB), polyvinyl acetate (PVAc) and DTDA‐THA via density functional theory, respectively. Three types of PBXs molding powders were prepared through the direct method. For further investigation, the moisture absorption of molding powders, the forming density, and the compressive strength of the grains under different binders were characterized. The result of the simulation shows higher binding energy between the crystal surface (2 −1 2) and different binders. The comprehensive order of the binding energies between different binders and the crystal surface of DTDA‐THA was DTDA‐THA@EVA>DTDA‐THA@PVB>DTDA‐THA@PVAc. The experimental results show that the addition of binder reduced the hygroscopicity of DTDA‐THA and improved the sensitivity and mechanical properties of the molding powders. Under the same binder proportion, the formulation prepared by PVAc had a higher molding density, while the formulation prepared by PVB exhibited the best compressive strength.
Inhibitory activity to Fusarium spp. and control potential for wheat Fusarium crown rot of a novel succinate dehydrogenase inhibitor cyclobutrifluram
Authors: Li Yiwen , Dai Tan , Tang Yidong , Wang Yan , Wang Xixi , Huang Zhongqiao , Li Feng , Lu Liang , Miao Jianqiang , Liu Xili 
Published: December 2023

AbstractBACKGROUNDWheat Fusarium crown rot (FCR) is a serious problem primarily caused by Fusarium pseudograminearum, a pathogenic agent known to produce mycotoxins, including deoxynivalenol (DON). Cyclobutrifluram, a novel succinate dehydrogenase inhibitor devised by Syngenta, has immense potential to control both nematodes and Fusarium diseases. However, its efficacy in combating Fusarium species, its ability to prevent and reverse the detrimental effects of FCR, and its impact on the production of DON by F. pseudograminearum are yet to be fully ascertained.RESULTSCyclobutrifluram exhibited substantial inhibitory activity against Fusarium species, with half‐maximal effective concentration values ranging from 0.0021–0.0647 μg mL−1. It demonstrated significant inhibitory activity toward three developmental stages of F. pseudograminearum, F. graminearum and F. asiaticum. Furthermore, cyclobutrifluram showed both protective and curative activities against FCR and was rapidly absorbed by roots and transported to wheat stems and leaves. Cyclobutrifluram could also decrease DON production by F. pseudograminearum.CONCLUSIONThis investigation has revealed the potential of cyclobutrifluram as a formidable candidate fungicide, particularly in its ability to effectively combat FCR and other Fusarium‐related ailments. This novel compound has exceptional pathogen‐fighting capabilities, coupled with remarkable systemic translocation properties and a notable ability to reduce the production of DON. © 2023 Society of Chemical Industry.
A longitudinal analysis of arrival infrastructures: The geographic pathways of EU labour migrants in the Netherlands
Authors: Loomans Dolly , Lennartz Christian , Manting Dorien 
Published: December 2023

AbstractAlthough traditional migration research focuses predominantly on large cities as ports of entry for migrants, increasingly more migrants start in smaller cities and rural areas. These mobility patterns give access to specific arrival infrastructures with differentiated and often unequal opportunities. Current research has addressed the multiplicity and political nature of arrival infrastructures, but what happens after arrival remains a black box. By building on micro register data, this study employs a longitudinal approach to trace the trajectories of EU labour migrants in the Netherlands across time and space. Our findings indicate that among those who choose to remain in the Netherlands, internal migration is largely characterized by geographical immobility. When people did move to a different type of residential location, it was often to more urbanized places. As mostly migrants with a higher income made these moves, this strengthened the dualization of more precarious migrants in rural areas and more well‐off migrants in larger cities.