bluuebunny/crossref_metadata_2025_split huggingface dataset:
Circuit mechanism underlying fragmented sleep and memory deficits in 16p11.2 deletion mouse model of autism
Authors: Choi Ashley , Smith Jennifer , Wang Yingqi , Shin Hyunsoo , Kim Bowon , Wiest Alyssa , Jin Xi , An Isabella , Hong Jiso , Antila Hanna , Thomas Steven , Bhattarai Janardhan P. , Beier Kevin , Ma Minghong , Weber Franz , Chung Shinjae 
Published: December 2023

ABSTRACTSleep disturbances are prevalent in children with autism spectrum disorder (ASD) and have a major impact on the quality of life. Strikingly, sleep problems are positively correlated with the severity of ASD symptoms, such as memory impairment. However, the neural mechanisms underlying sleep disturbances and cognitive deficits in ASD are largely unexplored. Here, we show that non-rapid eye movement sleep (NREMs) is highly fragmented in the 16p11.2 deletion mouse model of ASD. The degree of sleep fragmentation is reflected in an increased number of calcium transients in the activity of locus coeruleus noradrenergic (LC-NE) neurons during NREMs. Exposure to a novel environment further exacerbates sleep disturbances in 16p11.2 deletion mice by fragmenting NREMs and decreasing rapid eye movement sleep (REMs). In contrast, optogenetic inhibition of LC-NE neurons and pharmacological blockade of noradrenergic transmission using clonidine reverse sleep fragmentation. Furthermore, inhibiting LC-NE neurons restores memory. Rabies-mediated unbiased screening of presynaptic neurons reveals altered connectivity of LC-NE neurons with sleep- and memory regulatory brain regions in 16p11.2 deletion mice. Our findings demonstrate that heightened activity of LC-NE neurons and altered brain-wide connectivity underlies sleep fragmentation in 16p11.2 deletion mice and identify a crucial role of the LC-NE system in regulating sleep stability and memory in ASD.
Ventilation does not affect influenza virus transmission efficiency in a ferret playpen setup
Authors: Rockey Nicole C. , Sage Valerie Le , Shephard Meredith , Vargas-Maldonado Nahara , French Andrea J. , Walter Sydney , Ferreri Lucas M. , Holmes Katie E. , VanInsberghe David , Clack Herek , Prussin Aaron J. , Lowen Anice C. , Marr Linsey C. , Lakdawala Seema S. 
Published: December 2023

AbstractSustained community spread of influenza viruses relies on efficient person-to-person transmission. Current experimental transmission systems do not mimic environmental conditions (e.g., air exchange rates, flow patterns), host behaviors or exposure durations relevant to real-world settings. Therefore, results from these traditional systems may not be representative of influenza virus transmission in humans. To address this pitfall, we developed a modified, more realistic transmission setup and used it to investigate the impact of ventilation rates on transmission in a close-range, play-based scenario. In this setup, four immunologically naïve recipient ferrets were exposed to a donor ferret infected with a genetically barcoded 2009 H1N1 virus (H1N1pdm09) for four hours. The ferrets interacted in a shared space that included toys, similar to a child care setting. The transmission efficiency was determined under conditions of low and high ventilation rates; air exchange rates of ∼ 1.3 hr-1and 23 hr-1, respectively. Despite the large difference in ventilation rate, transmission efficiency was the same, 50% in two independent replicate studies. The presence of infectious virus or viral RNA on surfaces and in air throughout the exposure area was similar regardless of ventilation rate. While high viral genetic diversity in donor ferret nasal washes was maintained during infection, recipient ferret nasal washes displayed low diversity, revealing a narrow transmission bottleneck regardless of ventilation rate. Our findings indicate that in exposures characterized by frequent close-range, play-based interactions and the presence of fomites, ventilation does not significantly impact transmission efficiency.SignificanceImproved ventilation in building has the potential to reduce transmission of respiratory viruses, but its effect in different settings is not well understood. We developed a novel system to study influenza virus transmission in the ferret animal model in an environment that mimics a child care center. We demonstrate that increased ventilation is not effective at disrupting transmission in this setting, suggesting that transmission occurs mainly at close-range or via fomites. Multiple interventions are needed to reduce the spread of influenza virus in this type of setting.
Can tourists get used to the threat? A comparative study of tourists' behavioral intention during the COVID-19 pandemic
Authors: Młynkowiak-Stawarz Anna , Bęben Robert , Kraus Zuzanna 
Published: December 2023

PurposeThe purpose of this paper is to present a model depicting the relationship between the behavioral intention of tourists in the conditions prevailing during a pandemic and other variables.Design/methodology/approachIn constructing the research procedure, two measurements of tourist behavioral intention were taken into account, which were taken far apart in time. In verifying the developed model, the results of surveys of 1,615 people carried out in June 2021 and 917 people carried out in December 2021 were considered.FindingsAs a result of the habituation process, tourists show greater acceptance of the restrictions.Practical implicationsInformation on the basis of which companies make management decisions plays a significant role in the creation of company value. In the tourism sector, the information concerns primarily consumer behavior.Originality/valueChanges over time in risk perception, health protection motivation, and reactance due to perceived pandemic-related restrictions were taken into account in the context of behavioral intention towards tourism.
Does Critical HRD really exist outside academia?: An interview study with nine Critical HRD scholars
Authors: Kwon Chang-kyu , Archer Matthew 
Published: December 2023

Purpose
The complex world in which we reside is calling for more critical approaches to address the precarity experienced by the most marginalized in social systems. However, human resource development (HRD) lacks empirical data to describe, define and project the objectives and future directions of Critical HRD in today’s turbulent and volatile times. Therefore, the purpose of this study is to examine the historical and contemporary progression of Critical HRD, as described by nine of its most well-known scholars.

Design/methodology/approach
Data were collected through semistructured interviews, and a constructivist grounded theory coding approach was applied during analysis to identify themes and patterns.

Findings
The findings of this study highlight the persistent scholarship versus practice divide among Critical HRD scholars, suggesting that Critical HRD may merely be an academic undertaking and something not practiced within the public domain. The authors call for an evolution of Critical HRD toward more practice- and action-oriented approaches to scholarship and teaching so that meaningful changes can take place in actual organizations and workplaces.

Originality/value
To the best of the authors’ knowledge, this study was the first to empirically show that there is a real research–practice gap, particularly among Critical HRD scholars. Critical HRD scholars need to take these findings seriously as an opportunity to reflect on how they can take Critical HRD to the next level beyond academic discourse.
Bond market development and economic growth nexus in developing countries: a GMM approach
Authors: Ugbam Charles Ogechukwu , Ngong Chi Aloysius , Abner Ishaku Prince , Ibe Godwin Imo 
Published: December 2023

PurposeThis study examines the nexus of bond market development and economic growth from 2015 to 2022.Design/methodology/approachThe system-generalized method of moments (GMM) is employed on economic growth, government market capitalization, corporate market capitalization, bond yield, interest rate spread, trade openness and investment level.FindingsThe findings show that the government bond market, corporate bond capitalization and bond yield positively impact the gross domestic product (GDP). The results equally reveal a causal link between the corporate bond market, bond yield and GDP.Research limitations/implicationsGovernments should emphasize creating, developing and sustaining bond markets in the economies of developing countries to boost economic activity by promoting structural transformation. Policymakers should improve the implementation of existing rules and regulations while complementing them with new ones since well-developed bond markets provide alternative sources of financing that make economies financially resilient. Policymakers should encourage the issuance of corporate bonds to enhance the efficiency of the capital markets and mobilize funds for economic growth stimulation. Governments and corporations should diversify their sources of funding into the bond markets since the bond yields are favorable to economic growth.Originality/valueEarlier studies presented arguable results on the bond market development and economic growth nexus. Several findings indicate a positive link; others give a negative link between bond market development and economic growth. Some show causal directions, while other reveal none. The contradictory results motivate research. This research results contribute to the literature in that the government bond market, corporate bond capitalization and bond yield positively impact the GDP of developing nations.
Activity focus groups – a discursive, practical and social method for studying consumption practices
Authors: Weckroth Katri , Närvänen Elina 
Published: December 2023

Purpose
The purpose of this paper is to present a novel qualitative activity focus group (AFG) method for studying consumption practices. This participatory method, which is inspired by practice-theoretical thinking, combines focus group discussions with activities that represent the practices at the centre of the research.

Design/methodology/approach
The application of the AFG method is demonstrated with an empirical study of the transition to plant-based food consumption practices in Finland, involving four group sessions of 13 participants.

Findings
The findings from the empirical application of the AFG method illustrate that its key strength is the ability to foster fruitful and natural discussions on routine consumption practices that connect with discursive and practical dimensions and thus generate multidimensional data in resource-efficient ways.

Originality/value
The AFG method extends the methodological approaches in practice theory–oriented research, responding to the call for creative, real-life-reflecting methods that are able to grasp the discursive and embodied dimensions of practices. The method is proposed to be particularly suitable for research on mundane consumption practices.
What determines behavioural intention in health services? A four-stage loyalty model
Authors: George Ajimon , Sahadevan Jobin 
Published: December 2023

PurposeThis study aims to deal with the paucity of studies in the stages of the development of loyalty behaviour of customers in the healthcare context by incorporating three crucial service quality dimensions (physical environment, personnel quality and technical quality) and also investigating trust and commitment as mediating factors.Design/methodology/approachSurvey data were obtained from 420 respondents admitted to government hospitals in Kerala employing a convenience sampling method. The formulated hypotheses were tested using partial least square structural equation modelling.FindingsResults indicate that patient satisfaction, trust and commitment can create favourable behavioural intentions amongst patients. When patients reveal higher trust, they are more inclined to value healthcare services and willing to commit to a long-term relationship, resulting in increased patient loyalty.Practical implicationsOrganisational efforts should improve trust and commitment and build a good relationship between service providers and patients. Efforts should be taken to raise the standard of technical and personnel aspects, and a focus on physical infrastructure should also be considered to build a favourable behavioural intention to revisit and positive referrals.Originality/valueThis is the first empirical study to analyse technical quality, personnel quality and physical environment along with the mediating effect of trust, and commitment in a four-stage loyalty development model in the healthcare context of Kerala, India.
Efficacy and safety of intravenous fosphenytoin for patients with acute herpes zoster‐associated pain: A placebo‐controlled randomized trial
Authors: Iseki Masako , Yamamoto Takenobu , Ogawa Youichi , Majima Yuta , Abe Yoichiro , Watanabe Daisuke , Amaya Fumimasa , Hasegawa Toshio , Inafuku Kazuhiro , Kosugi Toshifumi , Nomura Yukiko , Deguchi Tokiko , Hamada Toshihisa , Shimizu Kenji , Arai Saori , Takahashi Morito , Hamada Izumi , Ishikawa Yuko , Kawashima Makoto 
Published: December 2023

AbstractAcute zoster‐associated pain develops in most patients with herpes zoster. Nonopioid analgesics are usually used to treat acute zoster‐associated pain but are frequently ineffective. We administered intravenous fosphenytoin, the prodrug of phenytoin, to patients with acute zoster‐associated pain to examine its analgesic efficacy and safety. At 13 medical institutions in Japan, we conducted a phase II, double‐blind, placebo‐controlled, randomized trial of intravenous fosphenytoin in Japanese inpatients with acute zoster‐associated pain for whom nonopioid analgesics had shown an insufficient analgesic effect. The patients were randomly assigned (1:1:1) to receive a single intravenous dose of fosphenytoin at 18 mg/kg (high dose), a single intravenous dose of fosphenytoin at 12 mg/kg (low dose), or placebo. The primary endpoint was the mean change per hour (slope) in the numerical rating scale score from the baseline score until 120 min after dosing. Seventeen patients were randomly assigned to the low‐dose fosphenytoin group (n = 6, median age 62.5 years, range 39–75 years), high‐dose fosphenytoin group (n = 5, median age 69.0 years, range 22–75 years), and placebo group (n = 5, median age 52.0 years, range 38–72 years). One patient was excluded because of investigational drug dilution failure. This study was discontinued because of the influences of coronavirus disease 2019. The slope was significantly lower in the high‐ and low‐dose fosphenytoin groups than in the placebo group (P < 0.001 and P = 0.016, respectively). Responsiveness to intravenous fosphenytoin (≥2‐point reduction in the numerical rating scale score from baseline to 120 min after dosing) was inferred at plasma total phenytoin concentrations of 10–15 μg/mL. Treatment‐emergent adverse events caused no safety concerns in the clinical setting and intravenous fosphenytoin was well tolerated. Intravenous fosphenytoin appears to be an effective and promising alternative treatment for acute zoster‐associated pain.Trial Registration: ClinicalTrials.gov NCT04139330.
Occupational Therapy Observation Tool–Adjustment Support Details for autistic children: Investigation of content validity and clinical utility
Authors: Kwok WingKwan Michelle , Bourke‐Taylor Helen , Carey Stuart , McKenzie Maria 
Published: December 2023

AbstractIntroductionStandardised testing is crucial for autistic children to receive appropriate interventions, necessary services, and funding. Behaviours associated with autism can hinder children's test performance and participation. The 18‐item, two‐page Occupational Therapy Observation Tool–Adjustment Support Details (OTOT‐ASD) is used in conjunction with standardised assessments. The OTOT‐ASD enables the recording of autism‐related behaviours and the reasonable assessment accommodations made to support participation in testing. The current study aims to investigate the content validity and clinical utility of the OTOT‐ASD from occupational therapists' perspectives.MethodA specifically designed online questionnaire was distributed Victoria‐wide to occupational therapists with clinical experience with autistic children. The questionnaire was designed in line with the COnsensus‐based Standards for selection of health Measurement INstruments (COSMIN), including relevance, comprehensiveness, and comprehensibility of items evaluated for content validity. Applicability and clinical usefulness were also investigated. Quantitative data were analysed using descriptive statistics.ResultsSeventy‐one occupational therapists responded to the questionnaire and 46 provided a full dataset. Over 96% of the respondents considered documenting behaviours and testing accommodations as important, yet less than 45% reported having resources to record this information. Ninety‐five percent of the respondents perceived the OTOT‐ASD to be useful in clinical practice. Over 70% agreed that OTOT‐ASD items were significantly relevant to practice and comprehensive. To improve comprehensibility, identified items were altered following feedback.ConclusionThe findings suggest that the OTOT‐ASD is clinically useful and content validity is sound. Further research on other psychometric properties of the OTOT‐ASD and users' qualitative experiences in utilising the tool is recommended.
Anthropogenic and natural disturbances increase local genetic diversity in an early spring geophyte (Ficaria verna Huds)
Authors: Guicking Daniela , Keßler Sarah , Störmer Eliza , Bersch Maggie , Duchoslav Martin 
Published: December 2023

AbstractThe tetraploid Ficaria verna is a common spring geophyte in central Europe and is considered invasive in the USA and Canada. It is considered an almost seed‐sterile taxon, relying on vegetative reproduction by underground tubers and aerial bulbils. Recent studies have revealed high levels of population genetic diversity in F. verna, raising the question of how genetic diversity is maintained and which factors may be responsible for the observed patterns. Polymorphic nuclear microsatellite markers were established to define multi‐locus genotypes (MLGs), to analyze fine‐scale spatial genetic structure (SGS) using grid and cross‐sampling schemes, and to quantify genetic diversity within and between nine populations with different disturbance regimes in central Germany. In total, 115 MLGs were identified among a total of 347 samples. The G/N ratio varied between 0.16 and 0.70 among populations, and in each population several unique MLGs occurred. Genotypes were highly intermingled within populations, suggesting a “guerrilla” dispersal strategy. Significant SGS (negative regression slope of kinship coefficients against inter‐individual distances) was found in four out of nine populations in fine‐scale cross‐sampling (up to 4 m) and in only one population in grid sampling (up to 14.6 m). No single MLG was found in more than one population, while many alleles were shared between populations. Within‐population clonal and allelic diversity increased with greater exposure to both anthropogenic and natural disturbances. Regular gap openings, facilitated propagule establishment, and propagule dispersal by water and mowing machines are likely important factors explaining the positive effects of disturbance on local genetic diversity of F. verna.
How Green Banks can create multiple types of value in the transition to net zero emissions
Authors: Lyons Michelle , White Lee Victoria 
Published: December 2023

AbstractCurrent levels of investment are insufficient to meet the goals of the Paris Agreement, and private sector funding shortfalls are acute. Despite this, little research has been undertaken into Green Banks, a new form of institution which mixes public and private institutional logics to mobilise additional private investment in the net zero transition. This paper examines how hybridity manifests in Green Banks and the ways these institutions create value through their investments. We adopt a mixed method, case study approach, combining primary document study with interviews, to elicit information on different forms of hybrid governance and value creation in four Green Banks (located in Australia, New Zealand, and the United States). We find some commonalities in how hybridity manifests between cases (e.g. combining public knowledge sharing logics with private investment logics), but also significant differences (e.g. in investment focus), as policymakers adapt organisational governance to suit jurisdictional circumstances. Green Banks are perceived to create value beyond their core financial roles, including knowledge spillovers, social equity benefits, and enhanced energy security. Current evaluation approaches focus on financial metrics and often exclude these broader areas of value creation. Development of additional value capture metrics could make Green Bank contributions more visible.Points for practitioners
Green Banks are hybrid organisations that seek to accelerate investments in low carbon infrastructure.
Green Banks aim to mobilise additional private finance to investments which would otherwise not occur, due to economic, social, or political barriers.
Green Banks demonstrate different forms of organisational hybridity and value creation at national, state, and local levels.
At present, the value created by Green Banks, particularly investments in disadvantaged communities, is not fully captured through investment evaluation processes.
The net zero transition is an opportunity to develop new forms of investment governance and evaluation which moves beyond capturing financial value to capture the value of investments more effectively.
Characteristics and outcome of systemic treatment for metastatic or unresectable thymic carcinoma: A single institution experience
Authors: Ho I‐Wei , Pan Yu‐Ling , Lai Jiun‐I , Liu Chun‐Yu 
Published: December 2023

AbstractBackgroundThymic carcinoma is a rare disease with an incidence of around 0.5 cases per million with a poor prognosis. The aim of this study was to assess patient outcomes with advanced thymic carcinoma receiving first‐line chemotherapy.MethodsIn our retrospective cohort study, we included patients who underwent treatment for metastatic thymic carcinoma between January 2013 to December 2019 in our hospital. Overall survival, progression‐free survival (PFS), objective response rates (ORR) and chemotherapy regimens were assessed and analyzed.ResultsA total of 27 patients were retrospectively analyzed. All patients received a platinum (cisplatin or carboplatin) based regimen as first‐line chemotherapy (29.6% received ADOC, 11.1% received PE, 40.7% received CP, 14.8% received CAP). The median PFS on first‐line chemotherapy was 199 days. The response rate was 40.7%. Median overall survival (OS) was 585 days. Positive CD5 staining was associated with better PFS.ConclusionWe highlight the critical role of platinum‐based chemotherapy agents as a primary treatment modality in advanced thymic carcinoma, underscoring the efficacy of platinum as a first‐line option for recurrent disease, even in cases previously treated with platinum. Additionally, our findings indicate that CD5 positivity could be associated with improved PFS, suggesting its potential as a prognostic marker.