bluuebunny/crossref_metadata_2025_split huggingface dataset:
Visualizing the spatial distribution of inflammation in the depressed brain with a targeted MRI nanoprobe in vivo
Authors: Zhang Peisen , Guan Jiaoqiong , Zhang Ni , Zhu Lichong , Wang Yu , Li Wenyue , Shi Zhe , Liu Xueyuan , Li Xue , Qin Meng , Hou Yi , Lan Yue 
Published: October 2023

AbstractDepression is a prevalent mental illness that imposes a substantial public health burden. However, the diverse clinical phenotypes observed in patients make it difficult to realize precise diagnosis. Recently, accumulating preclinical and clinical evidence has suggested that inflammation is involved in the pathophysiology of depression. Herein, a molecular imaging–based strategy was proposed as a means to diagnose depression precisely by specifically visualizing the inflammation status associated with depression. Inflammation-targeting MRI nanoprobes were constructed by attaching an intercellular cell adhesion molecule-1 (ICAM-1)-targeting peptide to biocompatible Fe3O4 nanoparticles. Systematic studies demonstrated that the nanoprobes could specifically target inflamed vascular endothelial cells and visualize the spatial distribution of inflammation in the depressed brain in vivo through susceptibility-weighted imaging (SWI), which was further confirmed by histological analysis. Additionally, these inflammatory brain regions identified by nanoprobe-based imaging are consistent with the focal regions closely associated with the symptoms of depression as reported in previous behavioral studies. Overall, this is the first study to directly visualize the distribution of inflammation in the depressed brain in vivo through a molecular imaging strategy, which may not only facilitate insight into the biological mechanism underlying depression but also provide a potential target within the depressed brain for the further development of anti-inflammatory therapies.
Rational design of large anomalous Nernst effect in Dirac semimetals
Authors: Wang Panshuo , Hu Zongxiang , Wu Xiaosong , Liu Qihang 
Published: October 2023

AbstractAnomalous Nernst effect generates a transverse voltage perpendicular to the temperature gradient. It has several advantages compared with the longitudinal thermoelectricity for energy conversion, such as decoupling of electronic and thermal transports, higher flexibility, and simpler lateral structure. However, a design principle beyond specific materials systems for obtaining a large anomalous Nernst conductivity (ANC) is still absent. In this work, we theoretically demonstrate that a pair of Dirac nodes under a Zeeman field manifests an odd-distributed, double-peak anomalous Hall conductivity curve with respect to the chemical potential and a compensated carrier feature, leading to an enhanced ANC compared with that of a simple Weyl semimetal with two Weyl nodes. Based on first-principles calculations, we then provide two Dirac semimetal candidates, i.e., Na3Bi and NaTeAu, and show that under a Zeeman field, they exhibit a sizable ANC value of 0.4 $${\rm{A}}{{\rm{m}}}^{-1}{{\rm{K}}}^{-1}$$

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and 1.3 $${\rm{A}}{{\rm{m}}}^{-1}{{\rm{K}}}^{-1}$$

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, respectively, near the Fermi level. Such an approach is also applicable to ferromagnetic materials with intrinsic Zeeman splitting, as exemplified by a hypothetical alloy NaFeTe2Au2, exhibiting an ANC as high as 3.7 $${\rm{A}}{{\rm{m}}}^{-1}{{\rm{K}}}^{-1}$$

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at the Fermi level. Our work provides a design principle with a prototype band structure for enhanced ANC pinning at the Fermi level, shedding light on the inverse design of other specific functional materials based on electronic structure.
Corrosion performance of wire arc additively manufactured NAB alloy
Authors: Shahriari Ayda , Chalasani Dharmendra , Amirkhiz Babak Shalchi , Mohammadi Mohsen 
Published: October 2023

AbstractNickel–aluminum bronzes (NAB) are vital alloys, known for biofouling resistance, crucial for marine and shipbuilding industries. This study examined corrosion performance of NAB samples fabricated by wire arc additive manufacturing (WAAM) in as-built and heat-treated conditions. Microstructural analysis revealed the WAAM-NAB parts primarily consisted of the α-phase (copper) and three types of κ-phases: κII (spherical Fe3Al), κIII (Ni–Al in lamellar shape) within the interdendritic areas, and iron-rich κIV particles dispersed throughout the matrix. In contrast, casting-produced NAB showed the formation of a rosette-like κI phase as well. Corrosion behavior comparisons between the two NAB fabrication methods were also assessed. The microstructural characterizations revealed a rise in the size of the κIV particles after heat-treated at 350 °C for 2 h (HT1). Heat treatment at 550 °C for 4 h (HT2) resulted in a needle-like κV, coarsening of κII, partial spheroidization of κIII, and reduced κIV precipitation. When heat-treated to 675 °C for 6 h (HT3), κII and κV were coarsened, κIII was completely spheroidized, and κIV precipitation was significantly reduced. These microstructural features in HT2 and HT3 conditions steeply decreased their corrosion resistance compared to the WAAM as-built part. The as-built WAAM sample showed superior corrosion resistance in chloride solution, attributed to fewer κ-intermetallic phases and a finer microstructure. The κ-phases, irrespective of morphology, act as the cathodic areas versus the α-dendritic matrix, fostering microgalvanic cell formation. Consequently, precipitation of all cathodic κ-phases draws a higher galvanic current of the anodic α-phase, meaning a lower corrosion resistance.
Non-targeted metabolomics aids in sex pheromone identification: a proof-of-concept study with the triangulate cobweb spider, Steatoda triangulosa
Authors: Fischer Andreas , Roman-Torres Andrea C. , Vurdela Jane , Lee Yerin , Bahar Nastaran , Gries Regine , Alamsetti Santosh , Chen Hongwen , Gries Gerhard 
Published: October 2023

AbstractTargeted metabolomics has been widely used in pheromone research but may miss pheromone components in study organisms that produce pheromones in trace amount and/or lack bio-detectors (e.g., antennae) to readily locate them in complex samples. Here, we used non-targeted metabolomics—together with high-performance liquid chromatography–mass spectrometry (HPLC–MS), gas chromatography-MS, and behavioral bioassays—to unravel the sex pheromone of the triangulate cobweb spider, Steatoda triangulosa. A ternary blend of three contact pheromone components [N-4-methylvaleroyl-O-isobutyroyl-l-serine (5), N-3-methylbutyryl-O-isobutyroyl-l-serine (11), and N-3-methylbutyryl-O-butyroyl-l-serine (12)] elicited courtship by S. triangulosa males as effectively as female web extract. Hydrolysis of 5, 11 and 12 at the ester bond gave rise to two mate-attractant pheromone components [butyric acid (7) and isobutyric acid (8)] which attracted S. triangulosa males as effectively as female webs. Pheromone components 11 and 12 are reported in spiders for the first time, and were discovered only through the use of non-targeted metabolomics and GC–MS. All compounds resemble pheromone components previously identified in widow spiders. Our study provides impetus to apply non-targeted metabolomics for pheromone research in a wide range of animal taxa.
Carbon price prediction based on decomposition technique and extreme gradient boosting optimized by the grey wolf optimizer algorithm
Authors: Feng Mengdan , Duan Yonghui , Wang Xiang , Zhang Jingyi , Ma Lanlan 
Published: October 2023

AbstractIt is essential to predict carbon prices precisely in order to reduce CO2 emissions and mitigate global warming. As a solution to the limitations of a single machine learning model that has insufficient forecasting capability in the carbon price prediction problem, a carbon price prediction model (GWO–XGBOOST–CEEMDAN) based on the combination of grey wolf optimizer (GWO), extreme gradient boosting (XGBOOST), and complete ensemble empirical mode decomposition with adaptive noise (CEEMDAN) is put forward in this paper. First, a random forest (RF) method is employed to screen the primary carbon price indicators and determine the main influencing factors. Second, the GWO–XGBOOST model is established, and the GWO algorithm is utilized to optimize the XGBOOST model parameters. Finally, the residual series of the GWO–XGBOOST model are decomposed and corrected using the CEEMDAN method to produce the GWO–XGBOOST–CEEMDAN model. Three carbon emission trading markets, Guangdong, Hubei, and Fujian, were experimentally predicted to verify the model’s validity. Based on the experimental results, it has been demonstrated that the proposed hybrid model has enhanced prediction precision compared to the comparison model, providing an effective experimental method for the prediction of future carbon prices.
Diagnosis of sarcopenia on thoracic computed tomography and its association with postoperative survival after anatomic lung cancer resection
Authors: Kaltenhauser Simone , Niessen Christoph , Zeman Florian , Stroszczynski Christian , Zorger Niels , Grosse Jirka , Großer Christian , Hofmann Hans-Stefan , Robold Tobias 
Published: October 2023

AbstractComputer tomography-derived skeletal muscle index normalized for height in conjunction with muscle density enables single modality-based sarcopenia assessment that accounts for all diagnostic criteria and cutoff recommendations as per the widely accepted European consensus. Yet, the standard approach to quantify skeletal musculature at the third lumbar vertebra is limited for certain patient groups, such as lung cancer patients who receive chest CT for tumor staging that does not encompass this lumbar level. As an alternative, this retrospective study assessed sarcopenia in lung cancer patients treated with curative intent at the tenth thoracic vertebral level using appropriate cutoffs. We showed that skeletal muscle index and radiation attenuation at level T10 correlate well with those at level L3 (Pearson’s R = 0.82 and 0.66, p < 0.001). During a median follow-up period of 55.7 months, sarcopenia was independently associated with worse overall (hazard ratio (HR) = 2.11, 95%-confidence interval (95%-CI) = 1.38–3.23, p < 0.001) and cancer-specific survival (HR = 2.00, 95%-CI = 1.19–3.36, p = 0.009) of lung cancer patients following anatomic resection. This study highlights feasibility to diagnose sarcopenia solely by thoracic CT in accordance with the European consensus recommendations. The straightforward methodology offers easy translation into routine clinical care and potential to improve preoperative risk stratification of lung cancer patients scheduled for surgery.
Aroma-based discrimination of Egyptian versus Indian guava fruits and in response to probiotics as analyzed via SPME/GC–MS and chemometric tools
Authors: Kamal Islam M. , Zayed Ahmed , Eissa Tarek F. , Farag Mohamed A. 
Published: October 2023

AbstractGuava tree (Psidium guajava L., Myrtaceae) is an economic grown worldwide, particularly in tropical and subtropical regions. Guavas encompass numerous cultivars (cvs.) that were discriminated in previous studies based on leaf morphological features and profile of volatile organic compounds (VOCs). Nevertheless, fruit VOCs have also shown outstanding potential for discrimination of other plant taxa, which has not been utilized in guava. Hence, the current study investigates the various guava cvs. harvested from India and Egypt. A total of 5 samples were analyzed by solid phase microextraction coupled to gas chromatography/mass spectrometry. Results led to the detection of 42 VOCs belonging to aldehydes, alcohols, esters, ketones, aliphatic and aromatic hydrocarbons, in addition to monoterpene and sesquiterpene hydrocarbons. Butylated hydroxytoluene and β-caryophyllene were predominant reaching 77% and 41% in Egyptian and Indian guava, respectively. The impact of probiotic fermentation, i.e., Lactobacillus acidophilus and L. plantarum on aroma profile was not significantly different (p > 0.05). Multivariate data analyses were further applied for samples classification and markers determination, including principal component analysis (PCA) and orthogonal partial least squares discriminant analysis (OPLS-DA). PCA score plot showed clear segregation of Egyptian from Indian specimens, whereas OPLS-DA revealed that β-caryophyllene was associated with white fruit versus 3-butenyl isothiocyanate and muurolol in red fruit type in the case of Indian guava. The richness of Egyptian guava in butylated hydroxytoluene in addition to the presence of vitamin C may potentiate its antioxidant activity, to be followed in subsequent studies regarding its health effects.
Association between Cu/Zn/Iron/Ca/Mg levels and cerebral palsy: a pooled-analysis
Authors: Zhu Haiquan , Mao Song , Li Wei 
Published: October 2023

AbstractIt was well documented that macro/trace elements were associated with the neurodevelopment. We aimed to investigate the relationship between copper (Cu)/zinc (Zn)/iron/calcium (Ca)/magnesium (Mg) levels and cerebral palsy (CP) by performing a meta-analysis. We searched the PubMed, Embase, Cochrane and Chinese WanFang databases from January 1985 to June 2022 to yield studies that met our predefined criteria. Standard mean differences (SMDs) of Cu/Zn/Iron/Ca/Mg levels between CP cases and healthy controls were calculated using the fixed-effects model or the random-effects model, in the presence of heterogeneity. 95% confidence intervals (CI) were also computed. Sensitivity analysis was performed by omitting each study in turn. A total of 19 studies were involved in our investigation. CP cases showed markedly lower Cu, Zn, iron and Ca levels than those in controls among overall populations (SMD =  − 2.156, 95% CI − 3.013 to − 1.299, P < 10−4; SMD =  − 2.223, 95% CI − 2.966 to − 1.480, P < 10−4; SMD =  − 1.092, 95% CI − 1.513 to − 0.672, P < 10−4; SMD =  − 0.757, 95% CI − 1.475 to − 0.040, P = 0.038) and Asians (SMD =  − 2.893, 95% CI − 3.977 to − 1.809, P < 10−4; SMD =  − 2.559, 95% CI − 3.436 to − 1.683, P < 10−4; SMD =  − 1.336, 95% CI − 1.807 to − 0.865, P < 10−4; SMD =  − 1.000, 95% CI − 1.950 to − 0.051, P = 0.039). CP cases showed markedly lower Zn level than that in controls among Caucasians (SMD =  − 0.462, 95% CI − 0.650 to − 0.274, P < 10−4). No significant differences of Cu, iron and Ca levels between CP cases and controls among Caucasians (SMD =  − 0.188, 95% CI − 0.412 to 0.037, P = 0.101; SMD =  − 0.004, 95% CI − 0.190 to 0.182, P = 0.968; SMD = 0.070, 95% CI − 0.116 to 0.257, P = 0.459) were observed. No marked difference of Mg level between CP cases and controls was noted among overall populations (SMD =  − 0.139, 95% CI − 0.504 to 0.226, P = 0.455), Asians (SMD =  − 0.131, 95% CI − 0.663 to 0.401, P = 0.629), and Caucasians (SMD =  − 0.074, 95% CI − 0.361 to 0.213, P = 0.614). Sensitivity analysis did not change the overall results significantly for Cu, Zn, iron and Mg. CP cases demonstrated significantly lower levels of Cu/Zn/iron/Ca than those in healthy controls, particularly in Asians. Decreasing trend of Cu/Zn/iron/Ca levels merit attention, particularly in the population with high susceptibility to CP. Frequent monitoring and early intervention may be needed.
Investigating microRNAs as biomarkers in disorders of consciousness: a longitudinal multicenter study
Authors: Musso Nicolò , Bivona Dalida , Bonomo Carmelo , Bonacci Paolo , D’Ippolito Maria Enza , Boccagni Cristina , Rubino Francesca , De Tanti Antonio , Lucca Lucia Francesca , Pingue Valeria , Colombo Valentina , Estraneo Anna , Stefani Stefania , Andriolo Maria , Bagnato Sergio 
Published: October 2023

AbstractMicroRNAs (miRNAs) are involved in gene regulation and may affect secondary brain injury and recovery in patients with disorders of consciousness (DoC). This study investigated the role of five miRNAs (150-5p, 132-3p, 23b-3p, 451a, and 16-5p) in prolonged DoC. miRNA levels were assessed in serum samples from 30 patients with unresponsive wakefulness syndrome or minimally conscious state due to traumatic or hypoxic-ischemic brain injury (TBI, HIBI) at baseline (1–3 months) and 6 months post-injury. Patients’ diagnoses were determined using the Coma Recovery Scale revised, and functional outcomes were evaluated 6 months after injury with the Glasgow Outcome Scale Extended (GOSE) and the Functional Independence Measure (FIM). Compared to healthy controls, patients with TBI had lower levels of miRNAs 150-5p, 132-3p, and 23b-3p at baseline, while patients with HIBI had lower levels of miRNA 150-5p at baseline and 6 months post-injury and a reduction of miRNA 451a at baseline. Higher levels of miRNAs 132-3p and 23b-3p were associated with better outcomes in TBI patients as indicated by GOSE and FIM scores. This study highlights distinct miRNA dysregulated patterns in patients with prolonged DoC, dependent on etiology and post-injury time, and suggests that miRNAs 132-3p and 23b-3p may serve as prognostic biomarkers.
Development of microcatheter tube extrusion angle estimation system using convolutional neural network segmentation
Authors: Jeong Seung Hyun , Lee Sang Heon , Won Hong-In 
Published: October 2023

AbstractThis study presents a deep learning-based monitoring system for estimating extrusion angles in the manufacturing process of microcatheter tubes. Given the critical nature of these tubes, which are directly inserted into the human body, strict quality control is imperative. To mitigate potential quality variations stemming from operator actions, a system utilizing a convolutional neural network to precisely measure the extrusion angle—a parameter with profound implications for tube quality—is developed. Until now, there has been no method to estimate the extrusion angle of resin being extruded in real-time. In this study, for the first time, a method using deep learning to estimate the angle was proposed. This innovative system comprises two RGB cameras capturing both front and side perspectives. The acquired images undergo segmentation via a meticulously trained convolutional neural network. Subsequently, the extrusion angle is accurately estimated through the application of principal component analysis on the segmented image. The usefulness of the proposed system was rigorously confirmed through comprehensive validation measures, including mean intersection over union (mIoU), mean absolute angle error (MAE), and inference time, using a real-world dataset. The attained metrics, with an mIoU of 0.8848, MAE of 0.5968, and an inference time of 0.0546, unequivocally affirm the system’s suitability for enhancing the catheter tube extrusion process.
Molecular mechanisms of NMDA excitotoxicity in the retina
Authors: Dvoriantchikova Galina , Fleishaker Michelle , Ivanov Dmitry 
Published: October 2023

AbstractNMDA excitotoxicity, as a part of glutamate excitotoxicity, has been proposed to contribute significantly to many retinal diseases. Therefore, understanding mechanisms of NMDA excitotoxicity will provide further insight into the mechanisms of many retinal diseases. To study mechanisms of NMDA excitotoxicity in vivo, we used an animal model in which NMDA (20 mM, 2 µL) was injected into the vitreous of mice. We also used high-throughput expression profiling, various animals with reduced expression of target genes, and animals treated with the oral iron chelator deferiprone. We found that the expression of many genes involved in inflammation, programmed cell death, free radical production, oxidative stress, and iron and calcium signaling was significantly increased 24 h after NMDA treatment. Meanwhile, decreased activity of the pro-inflammatory TNF signaling cascade and decreased levels of ferrous iron (Fe2+, required for free radical production) led to significant neuroprotection in NMDA-treated retinas. Since increased TNF signaling activity and high Fe2+ levels trigger regulated necrosis, which, in turn, lead to inflammation, we proposed an important role in NMDA excitotoxicity of a positive feedback loop in which regulated necrosis promotes inflammation, which subsequently triggers regulated necrosis.
Aerosol high water contents favor sulfate and secondary organic aerosol formation from fossil fuel combustion emissions
Authors: Huang Xiaojuan , Liu Zhe , Ge Yanzhen , Li Qing , Wang Xiaofei , Fu Hongbo , Zhu Jian , Zhou Bin , Wang Lin , George Christian , Wang Yan , Wang Xinfeng , Su Jixin , Xue Likun , Yu Shaocai , Mellouki Abdewahid , Chen Jianmin 
Published: October 2023

AbstractFine-particle pollution associated with high sulfate and secondary organic aerosol (SOA) contents still occurs in winter, despite considerable reductions in precursor emissions in China. The chemical mechanisms involved are consistently acknowledged to be linked with aerosol water but remain poorly understood. Here, we present findings demonstrating that the synergistic effect of elevated aerosol water content and particles originating from fossil fuel combustion significantly enhanced the rapid formation of sulfate and SOAs under high humidity conditions during winter in northern China. The presence of high aerosol water content promoted the aging process of particles containing elemental carbon (EC) and facilitated the formation of SOAs. Evidence from single particles reveals an increased potential for SOA formation from primary organic aerosols (POAs) originating from fossil fuel combustion, in the presence of increasing aerosol water. Under conditions of relative humidity exceeding 85%, the multiphase oxidation of SO2 by in-particle nitrite/nitrous acid, generated through reactions involving aged EC-containing and iron-rich particles, as well as aqueous-phase formation of hydroxymethanesulfonate (HMS), led to a substantial increase in sulfate production. This study emphasizes the critical role of aerosol water in the aerosol chemistry concerning sulfate and SOAs, highlighting the urgent necessity to mitigate primary emissions from fossil fuel combustion.
The Hoffmann-Tinel Sign: Historical Background and Clinical Significance
Authors: Siqueira Mario Gilberto , Martins Roberto Sergio 
Published: October 2023

AbstractThe Hoffmann-Tinel sign is well-known to professionals dealing with nerve lesions and is widely used as a provocative test. It was described by Paul Hoffman and Jules Tinel in the same year (1915), independently. In the present article, a biographical sketch of both authors is presented and the method for eliciting the sign and the sometimes controversial information of its results are discussed.
The Importance of Orthostatic Radiography in the Management of Thoracolumbar Fractures: Case Report
Authors: Fortunato Pedro Neves , Fernandes Yvens Barbosa , Joaquim Andrei Fernandes 
Published: October 2023

AbstractPatients who are victims of traumatic injuries in the spine are evaluated by radiological protocols, as recommended by Advanced Trauma Life Support (ATLS), including a computed tomography (CT) scan with the patient in the decubitus position. Spine fractures considered stable with initial nonoperative management should be further evaluated with a standard simple plain radiograph in orthostasis and/or a magnetic resonance image (MRI), to exclude any associated ligament injury and avoid neurological damage caused by occult instabilities. We present an illustrative case with an injury diagnosed through orthostasis X-ray to discuss its importance in the management of thoracolumbar fractures.