bluuebunny/crossref_metadata_2025_split huggingface dataset:
Cytokine profile of anti-spike CD4+T cells predicts humoral and CD8+T cell responses after anti-SARS-CoV-2 mRNA vaccination
Authors: Tartour Eric , Benhamouda Nadine , Besbes Anissa , Bauer Rebecca , Mabrouk Nesrine , Gadouas Gauthier , Desaint Corinne , Chevrier Lucie , Lefebvre Maeva , Radenne Anne , Roelens Marie , Parfait Béatrice , Weiskopf Daniela , Sette Alessandro , Gruel Nadège , courbebaisse Marie , Appay Victor , Paul Stéphane , Gorochov Guy , Ropers Jacques , Lebbah Said , Lelièvre Jean-Daniel , Johannes Ludger , Ulmer Jonathan , Lebeaux David , FRIEDLANDER Gérard , de Lamballerie Xavier , RAVEL Patrice , Kieny Marie-Paule , Batteux Frederic , Durier Christine , Launay Odile 
Published: October 2023

Abstract
Coordinating immune responses – humoral and cellular – is vital for protection against severe Covid-19. Our study evaluates a multicytokine CD4+T cell signature’s predictive potential for post-vaccinal serological and CD8+T cell responses. A cytokine signature composed of four cytokines (IL-2, TNF-α, IP10, IL-9) excluding IFN-g and generated through machine learning, effectively predicted the CD8+T cell response following mRNA-1273 or BNT162b2 vaccine administration. Its applicability extends to murine vaccination models, encompassing diverse immunization routes (such as intranasal) and vaccine platforms (including adjuvanted proteins). Notably, we found correlation between CD4+T lymphocyte-produced IL-21 and the humoral response. Consequently, we propose a straightforward test that offers a rapid overview and deepens our understanding of complex immune responses. This approach holds particular relevance for scenarios involving immunocompromised patients or pandemics. This study also underscores the pivotal role of CD4+T cells during a vaccine response, presenting an opportunity harnessing this role in vaccine immunomonitoring.
Ceramic Soft Tissue Trimming Bur versus Conventional Scalpel Technique in Gingival Depigmentation Procedure: A Split-mouth Randomized Clinical Trial
Authors: Nassar Sally Khaled , Abuel-Ela Hala Ahmed , Fouad Yasmine Ahmed 
Published: October 2023

Abstract
Objectives:
Ceramic soft tissue trimming bur (Cerabur) was primarily launched to be used in gingivoplasty but has been used recently in gingival depigmentation. Cerabur depigmentation has the advantage of good hemostasis because of blood coagulation by frictional heat. This study aimed to compare the efficacy of depigmentation using the novel cerabur versus the gold-standard surgical scalpel technique.
Materials and methods:
Eight healthy, non-smokers with moderate to severe gingival hyperpigmentation in both arches were randomly assigned for cerabur depigmentation in one arch [test group (TG)] and scalpel depigmentation in the opposite arch [control group (CG)]. Pigmentation indices, pain levels, patient satisfaction, treatment time as well as re-pigmentation rates were the assessed parameters. The assessment was at baseline, 1 week, 1 month, and 3 months.
Results:
At all the assessment visits the pigmentation intensity represented by Dummet oral pigmentation index (DOPI), and distribution represented by Hedin melanin index (MI) were significantly less than baseline (p <0.001) in both groups.
When comparing both groups, Scalpel depigmentation had better initial clinical outcomes, while Cerabur had less visible re-pigmentation, pain Scores, and treatment time, along with more patient satisfaction. However, all these differences were statistically insignificant.
Conclusion: Both techniques successfully removed the gingival hyperpigmentation with comparable clinical outcomes. Cerabur depigmentation was favored by the patients.
Clinical relevance:
Gingival hyperpigmentation is an esthetic problem for many individuals. Investigating a simple, cost-effective, and bloodless depigmentation technique would be beneficial to both the clinician and the patient.
A retrospective study of endoscopic treatment of esophageal fistulas on the efficacy and safety
Authors: Zuo Jiaxuan , Zhao Yan , Li Hengcun , Li Peng , Zhang Shutian 
Published: October 2023

Abstract

Background
There are currently no standard treatments for esophageal fistulas (EFs) and endoscopic therapy may be recommended with minimally invasive and lower mortality. This study aims to investigate the efficacy and safety of endoscopic treatment in treating EFs and the standardized evidence-based strategy for the management of EFs.
Methods
We retrospectively studied patients with EFs who underwent endoscopic treatment or best supportive care (BSC) for 12 years. The success rate, survival, and other clinical data were compared.
Results
A total of 52 patients were included in this study, including 16 stents, 7 through-the-scope-clips, 2 over-the-scope-clips, 1 endoscopic suturing, and 26 BSC. The clinical success rate was higher in endoscopic treatment compared with BSC treatment (76.9% vs 33.3%, P = 0.002). Endoscopic treatment leads to higher survival rates for patients with malignant EFs than BSC (125 days vs 62 days, hazard ratio = 0.35, P = 0.042). In contrast, those with benign EFs had a similar overall survival rate. Endoscopic treatment maintains hemoglobin levels and lower CRP in EF patients (P = 0.733, P = 0.019). In addition, endoscopic treatment better maintains ECOG and nrs2002 scores for patients with malignant EFs. (0.00 vs -0.50, 0.00 vs -0.50, P = 0.037, P = 0.021). Adverse events occurred in 8 (30.8%) patients treated with esophageal stents; two (7.7%) were significant complications.
Conclusion
Endoscopic treatment is a safe option for patients with EFs. For benign EFs, endoscopic therapy can be an option for inoperable patients or as a bridge before surgery. For malignant EFs, self-expendable metallic stents (SEMS) can be the first line of treatment.
Challenges and Opportunities in perinatal public health: The utility of perinatal health inequality dashboards in addressing disparities in maternal and neonatal outcomes
Authors: Olakotan Olufisayo , Lim Jennifer NW , Pillay Thillagavathie 
Published: October 2023

Abstract

Introduction: In clinical settings, digital dashboards display medical data, with the aim of identifying trends and signals. In so doing these contribute towards improving service delivery and care within hospitals. It is not clear whether the utility of perinatal health equity dashboards could be used to identify health inequality trends that could potentially impact on health service delivery, care and public health interventions. This scoping review examines the usefulness of health inequality dashboards in improving maternal and neonatal care, specifically for disadvantages populations.
Methods: We searched the Embase, CINAHL, and Medline databases for articles published between 2010 and 2022, using keywords such as health inequality dashboard, maternal care disparities, neonatal care disparities, maternal mortality. We included grey literature searches. Our searches identified 661 articles, of which 13 met the inclusion criteria.
Results: Our study findings highlight the necessity of utilizing perinatal health inequality dashboards in maternal and neonatal care to enhance health equity and inform policymaking. We identified three key themes: functions of the dashboard and types of data, data accuracy, and challenges in collecting data on health inequalities. We also suggest strategies, including the use of publicly available databases.
Conclusion: The integration of perinatal health inequality dashboards stands as a critical step forward in optimizing maternal and neonatal care. These tools not only serve to foster health equity but also act as a vital resource for informing nuanced policy decisions. Through adopting innovative strategies, including capitalizing on publicly available databases, we can further streamline efforts to address existing disparities and pave the way for enhanced healthcare outcomes in this sector.
The impact of climate change on grain yield and biomass of winter wheat and sunflower in Northwest Turkey
Authors: Bakanoğulları Fatih 
Published: October 2023

Abstract
Prediction of crop yield and biomass in agricultural production is crucial for both food safety and national economic projections. This study aimed to determine the relationship between the effects of climate change and biomass and grain yield of two crops at two locations, Kirklareli (KRK), Edirne-Orhaniye (EOL), with different soil textures in the Thrace region of Turkey. The effects of climate change were analyzed by using sixty-five different climate scenarios (n = S1, S2, …, S65) for sunflower and winter wheat crops with the AquaCrop model. The model predicted the highest grain yield and biomass loss when the air temperature was increased by 5°C and the precipitation was decreased by 50% during the growing seasons of both crops. In the scenarios where only temperature was increased, yield and biomass values of sunflower was decreased, while those of winter wheat was increased. The combined effects of increased global solar radiation and decreased temperature had a negative effect on wheat production at EOL. For both sunflower and wheat, the most negative impacts on yield and biomass production were observed with the combined scenarios of various temperature increases and precipitation decreases during each growing season at each location. Finally, under the defined climate scenarios, the correlation coefficients between sunflower and winter wheat biomass and grain yields were found to be R2 = 0.88 and 0.87 for KRK and R2 = 0.56, and 0.79, for EOL, respectively.
A Traffic Flow Control Method Using a Connected and Automated Vehicle at Signalized Intersection
Authors: Yang Hanyi , Zou Rong , Zhang Guohui 
Published: October 2023

Abstract
The development of connected and autonomous vehicles (CAV) makes it possible to control traffic flow propagation to reduce travel time and/or fuel consumption. This study develops an adaptive CAV trajectory control (ACTC) method to minimize the fuel consumption of the whole traffic flow on a signalized approach under mixed traffic condition (CAVs and Human-driven vehicles coexisting) by controlling a CAV’s trajectory. First, a fuel consumption oriented optimal trajectory control model is built up. Next, a traffic state-based fuel consumption function is developed to illustrate the relationship between fuel consumption and traffic state. Also, an estimation algorithm of CAV impacted traffic state evolution is developed, which is taken as the dynamic function. Finally, dynamic programming is employed to solve the proposed optimal control model. The performance of the ACTC is validated by a simple numerical experiment at a 2500 ft long approach with signalized control. The experiment results show that the proposed method is effective is fuel consumption.
Agreement between self-reported and registered age at asthma diagnosis in Finland
Authors: Nurmi Elias , Vähätalo Iida , Ilmarinen Pinja , Andersén Heidi , Tuomisto Leena , Sovijärvi Anssi , Backman Helena , Lehtimäki Lauri , Hedman Linnea , Langhammer Arnulf , Nwaru Bright , Piirilä Päivi , Kankaanranta Hannu 
Published: October 2023

Abstract
Introduction
In epidemiological studies, the age at asthma onset is often defined by patients’ self-reported age at diagnosis. The reliability of this report might be questioned. Our objective was to evaluate the agreement between self-reported and registered age at asthma diagnosis and assess features contributing to the agreement.
Methods
As part of the FinEsS respiratory survey in 2016, randomly selected population samples of 13435 from Helsinki and 8000 from Western Finland were studied. Self-reported age at asthma diagnosis was compared to age at asthma diagnosis registered in the Finnish register on special reimbursement for asthma medication. The reimbursement right is based on lung function criteria according to GINA and Finnish guidelines. If the difference was less than 5 years, self-reported diagnosis was considered reliable. Features associated with the difference between self-reported and registered age at asthma diagnosis were evaluated.
Results
Altogether 197 subjects from Helsinki and 144 from Western Finland were included. Of these, 61.9% and 77.8%, respectively, reported age at diagnosis reliably. Median difference between self-reported and registered age at diagnoses was −2.0 years (IQR −9.0 to 0) in Helsinki and −1.0 (IQR −4.3 to 0) in Western Finland indicating earlier self-reported age at diagnosis. More reliable self-report was associated with non-allergic subjects and subjects who reported having asthma diagnosis more recently.
Conclusions
Agreement between self-reported and registered age at asthma diagnosis was good especially with adult-onset asthma patients. Poor agreement in early-onset asthma could be related to delay in registration due to reimbursement criteria.
Changes in the components of physical fitness determining health of young adults - on the example of a long-term observation of physiotherapy students from Bydgoszcz (Poland) in the years 2001-2020
Authors: Lewandowski Andrzej , Siedlaczek Marcin , Piekorz Zuzanna , Kryst Łukasz 
Published: October 2023

Abstract

Introduction
The aim of the study was to assess the changes in the components of physical fitness that are conducive to the health of young people surveyed in the years 2001–2020. Hypotheses were formulated about the increase in the thickness of skinfolds, especially among women, the deterioration of the results of fitness tests and the lack of conditioning of the examined changes with socio-economic factors.
Materials and methods
Every year, physiotherapy students of Collegium Medicum in Bydgoszcz, Nicolaus Copernicus University in Toruń (Poland) were examined in terms of body height and weight, skinfolds and flexibility, static strength, abdominal muscle strength, functional strength and endurance. Results were obtained from 1161 female students and 464 male students.
Results
A similar changes course was observed for most of the studied characteristics of people of both sexes. In men, there was a decrease in biceps skinfold (R2 = 0.455, p = 0.002) and lower leg (R2 = 0.314, p = 0.015). In women, there was an increase in body weight (R2 = 0.41, p = 0.003), a decrease in skinfold over the biceps (R2 = 0.477, p = 0.001) and worsened flexibility (R2 = 0.283, p = 0.023). It was found that male sex and suprailiac skinfold are frequent predictors of the examined motor characteristics and socioeconomic determinants do not significantly affect their maintenance.
Conclusions
The obtained results, except for a few examples in somatic features and flexibility of women, showed their stability and lack of conditioning by social factors as well as by the fitness test. Attention to the appropriate level of the observed components is justified, especially in the light of the identified trace of the trend which shows their deterioration.
The Botanical Status of the COM Clade in Rosidae
Authors: Yao Huipeng , Peng Hong , Qing Hua , Li Tingting , Huang Yan , Yu Guozhi , Zhang Huaiyu , Huang Zhongchao , Chen Xi , Liang Fangyun , Zhang Yuxin , Cai Yi 
Published: October 2023

Abstract
The taxonomic status determination of populations plays a crucial role in the conservation and management of global biodiversity. The Celastrales–Oxalidales–Malpighiales (COM) clade, an important component of Rosidae, holds a significant position within the angiosperms. In this study, systematic phylogenetic analyses were conducted on the mitochondrial genomes, chloroplast genomes, and nuclear genomes of all sequenced species within the COM clade using three different methods. Phylogenetic analysis of eight conserved mitochondrial genes from 34 plant species revealed that under high-confidence conditions, the COM clade is not affiliated with fabids or malvids, indicating a parallel relationship. However, analysis of four additional conserved mitochondrial genes suggested a closer affinity of the COM clade to malvids than to fabids. A phylogenetic analysis of 49 conserved chloroplast genes from 57 plant species showed that the COM clade is parallel to both fabids and malvids, rather than belonging to either group. The results from 45 chloroplast genes indicated that the three subgroups within the COM clade are parallel to each other and parallel to fabids and malvids. The majority of results from the four conserved genes support a parallel relationship between the main branch of COM and malvids, with a closer affinity to fabids than to other groups. A systematic phylogenetic analysis of 879 conserved nuclear genes from five fabid species, five malvid species, and all species within Celastrales, Malpighiales, and Asteridae revealed that the three subgroups within the COM clade are parallel to each other and parallel to fabids and malvids under high-confidence conditions. In conclusion, the systematic phylogenetic trees based on mitochondrial genomes, chloroplast genomes, and nuclear genomes of all analysable conserved genes collectively demonstrate that the COM clade belongs to neither the fabids nor the malvids but is parallel to them.
Effect of Postpartum Depression and Role of Infant Feeding Practices on Relative Weight of Child at 1 and 3 Years of Age
Authors: Shrestha Drishti , Bhandari Aliza K C , Ogawa Kohei , Tanaka Hisako , Miyayama Chiharu , Horikawa Reiko , Urayama Kevin Y. , Morisaki Naho 
Published: October 2023

Abstract

Background
Childhood obesity has increased and is considered one of the most serious public health challenges of the 21st century globally, and may be exacerbated by postpartum depression (PPD). The purpose of this study was to examine the association between PPD at 1st and 6th month postpartum, infant feeding practices, and body mass index (BMI) z-score of the child at one and three years of age.
Methods
This study used data from an ongoing prospective maternal-child birth cohort performed at the National Center for Child Health and Development (NCCHD) in suburban Tokyo, Japan with the period of recruitment from May 13, 2010 to November 28, 2013. Out of 2,309 total number of mothers, 1,279 mother-child dyads were assessed in the study. We performed multivariable linear regression analysis to examine the association between PPD and child’s BMI z-score stratified by the child’s age at 1 year and 3 years of age.
Results
The prevalence of PPD at 1 month postpartum (17%) was found to be higher than at 6 months (12%). In multivariable linear regression analysis we observed that children at 3 years who had mothers with PPD at 6 months had, on average, a BMI z-score 0.25 higher than children of mothers who did not have PPD at 6 months (ß coefficient 0.25, 95% CI [0.04 to 0.46], p value 0.02), holding all other covariates constant. Also, initiation of weaning food when child is at six months of age was associated with higher BMI z-score of the child at 3 years after adjusting for all covariates (ß coefficient = 0.18, 95% CI [0.03 to 0.34], p-value < 0.05).
Conclusion
The significant association between PPD at 6 months and child’s BMI z-score at 3 years of age, in conjunction with birth trends and high prevalence of PPD, can add to the body of evidence that there is need for multiple assessment across the first postpartum year to rule out PPD as early screening and early interventions may benefit both maternal health and child development outcomes. These findings can indicate the need for establishing support systems for care-giving activities for mothers with PPD.
Metal Pollution, Environmental Assessment and Suggested Solutions in the Recent Bottom Sediments of Qaroun Lake, Fayoum, Egypt
Authors: M.G. Mahmoud , G.S. Salem , M. Dawoud , I.M.L Lotfy , M.M Abu El-Hasan , A. El-Dokouny H. 
Published: October 2023

Abstract
Qaroun Lake is located in the deepest area of the Fayoum depression, within the western desert and about 83 kilometres south of Cairo. The current study aimed to determine the distribution of polluting elements resulting from the wastewater discharge of these drains as a significant source of pollution. Sediment in Qaroun Lake was sandy silt in the east zone, while the middle and west were silty sand and sandy silt. The heavy metals mentioned were found in higher amounts in the eastern and middle parts of the lake's recent bottom sediments, in contrast to the western area, where their concentration was lower. The metal pollution in the lake was measured by using single indices like contamination factor, enrichment factor, ecological risk factor, and index of I geo accumulation, combining indices like the degree of contamination, ecological risk factor, and potential ecological risk index. The results revealed that the distribution of the measured heavy elements over the lake was found in the range of (0.55–7.72%), (227–1840 ppm), (43–174 ppm), (24–76 ppm), (18–42 ppm), (48–114 ppm), (31–94 ppm), (21–49 ppm), and (583–4944 ppm) for Iron, Manganese, Zinc, Copper, Lead, Cobalt, Nickel, Rubidium, and Strontium; respectively which means all parts of Qaroun Lake show high contamination levels (Cd). The ecological risk factor (PLI) indicates no contamination in most stations, except for one close to the polluted El-Wadi drain. The potential ecological risk index (RI) is low in all stations around Qaroun Lake.
Stripe Noise Removal in Scanning Probe Microscopy
Authors: Li Mian , Rieck Jan , Noheda Beatriz , Roerdink Jos B.T.M. , Wilkinson Michael H.F. 
Published: October 2023

Abstract
Conductive atomic force microscopy (c-AFM) can provide simultaneous maps of the topography and electrical current flow through materials with high spacial resolution and it is playing an increasingly important role in the characterization of novel materials that are being investigated for novel memory devices. However, noise in the form of stripe features often appear in c-AFM images, challenging the quantitative analysis of conduction or topographical information. To remove stripe noise without losing the interesting information, as many as sixteen destriping methods are investigated in this paper, including three additional models that we propose based on the stripes characteristics and thirteen state-of-the-art destriping methods. We have also designed a gradient stripe noise model and obtained a ground truth dataset consisting of 800 images, generated by rotating and cropping a clean image, and a noisy image dataset, created by adding random intensities of simulated noise to the ground truth dataset. In addition to comparing the results of the stripe noise removal visually, we performed a quantitative image quality comparison using simulated datasets and five images with very different strengths of simulated noise. All results show that the Low-Rank Recovery method has the best performance and robustness in removing varying degrees of gradient stripe noise without losing useful information in c-AFM images.