bluuebunny/crossref_metadata_2025_split huggingface dataset:
Bioactive adrenomedullin (bio-ADM) is associated with endothelial dysfunction in infants and children with complex congenital heart disease undergoing open-heart surgery on cardiopulmonary bypass
Authors: Schaefer Maike , Stein Andreas , Ruf Bettina , Balling Gunter , Palm Jonas , Simmelbauer Andreas , Cleuziou Julie , Sander Michaela , Auer Josef , Borgmann Kristina , Struck Joachim , Hartmann Oliver , Schulte Janin , Hörer Jürgen , Tassani-Prell Peter , Ewert Peter , Holdenrieder Stefan , Wolf Cordula M. 
Published: October 2023

Abstract

Objectives
Children with congenital heart disease (CHD) undergoing cardiac surgery on cardiopulmonary bypass (CPB) are at risk for systemic inflammation leading to endothelial dysfunction associated with increased morbidity. Bioactive adrenomedullin (bio-ADM) is a peptide regulating vascular tone and endothelial permeability. The aim of this study was to evaluate the dynamics of plasma bio-ADM in this patient cohort and its role in capillary leak.

Methods
Plasma samples from 73 pediatric CHD patients were collected for bio-ADM measurement at five different timepoints (TP) in the pre-, intra-, and post-operative period. The primary endpoint was a net increase in bio-ADM levels after surgery on CPB. Secondary endpoints included association of bio-ADM levels with clinical signs for endothelial dysfunction.

Results
Bio-ADM levels increased after surgery on CPB from pre-operative median of 12 pg/mL (IQR [interquartile range] 12.0–14.8 pg/mL) to a maximum post-operative median of 48.8 pg/mL (IQR 34.5–69.6 pg/mL, p<0.001). Bio-ADM concentrations correlated positively with post-operative volume balance, (r=0.341; p=0.005), increased demand for vasoactive medication (duration: r=0.415; p<0.001; quantity: TP3: r=0.415, p<0.001; TP4: r=0.414, p<0.001), and hydrocortisone treatment for vasoplegia (bio-ADM median [IQR]:129.1 [55.4–139.2] pg/mL vs. 37.9 [25.2–64.6] pg/mL; p=0.034). Patients who required pleural effusion drainage revealed higher bio-ADM levels compared to those who did not (median [IQR]: 66.4 [55.4–90.9] pg/mL vs. 40.2 [28.2–57.0] pg/mL; p<0.001).

Conclusions
Bio-ADM is elevated in children after cardiac surgery and higher levels correlate with clinical signs of capillary leakage. The peptide should be considered as biomarker for endothelial dysfunction and as potential therapeutic target in this indication.
Innovations in HbA1c analysis: finding the balance between speed and accuracy. An investigation of a potential new Secondary Reference Measurement Procedure for the IFCC
Authors: Lenters-Westra Erna , English Emma 
Published: October 2023

Abstract

Objectives
The escalating prevalence of diabetes worldwide has resulted in a dramatic increase in the number of people who need testing, which in turn necessitates faster HbA1c measurement. The Tosoh GR01 addresses the need for fast turnaround times of whilst offering pragmatic steps to maintain result accuracy in a single instrument by offering two distinct operating modes: Short Mode (SM) and Long Mode (LM). The aim of this study was to evaluate all relevant aspects of the performance of the Tosoh GR01 with a view to accepting the instrument as a future Secondary Reference Measurement Procedure (SRMP) for the IFCC.

Methods
Certified Clinical & Laboratory Standards Institute (CLSI) Evaluation Protocols (EP) were used to evaluate precision (EP-5), accuracy (EP-9), linearity (EP-6), carry-over (EP-10) and the effect of hemoglobin variants and other potential interferences.

Results
Both modes demonstrated CVs <0.6 % in SI units and <0.4 % in NGSP units at 46 mmol/mol (6.4 %) and 75 mmol/mol (9.0 %) and passed both National Glycohemoglobin Standardization Program (NGSP) and International Federation of Clinical Chemistry and Laboratory Medicine (IFCC) certification procedures when compared with 7 IFCC Certified Secondary Reference Measurement Procedures (SRMP). Sigma for both modes was >6 when using the results of EP-5 and EP-9 at an HbA1c concentration of 50 mmol/mol (6.7 %). Neither mode showed any interference with common Hb-variants except for HbAE when HbA1c was >65 mmol/mol. In the SM HbAS, HbAD and HbAC were recognized but no result was reported.

Conclusions
There is a good balance between speed and accuracy for determining HbA1c with the Tosoh GR01 in both analytical modes and the device is suitable for use as an IFCC SRMP.
Language maintenance and shift in a Swiss community on the Black Sea
Authors: Bichurina Natalia 
Published: October 2023

Abstract
This paper explores the dynamics of the linguistic situation in a Swiss colony of Shabo on the Black Sea, created in 1822. Its political belonging changed several times: from the Russian empire to the Kingdom of Romania and the USSR (today Ukraine). Metalinguistic discourse produced by various social actors in different sociopolitical settings is compared here to the use of Francoprovençal, French, and Russian as discovered in archival data. Accordingly, the study is based, on the one hand, on the narratives in manuscripts and publications (from the Archives of Odessa, Bern, and Romainmôtiers), and on the other hand, on a corpus of private letters (from family archives in Vaud), as well as early (socio)linguistic descriptions compared to linguistic data collected in Vaud. This case study aims to shed light on the complex relationship between the linguistic processes and language ideologies in changing socio-political spaces.
Locating the ‘Age of Prescriptivism’ in Late Modern periodical reviews: a corpus-assisted discourse analytic approach
Authors: Malory Beth 
Published: October 2023

AbstractThis paper reports the findings of a corpus-based study of prescriptive and normative discourses in Late Modern English review periodicals, using a purpose-built diachronic corpus of review articles published during the period 1750–1899. Drawing on established protocols from Corpus-Assisted Discourse Studies and systematic comparison of 15 sub-corpora, it identifies decades during which prescriptive discourses were most frequent. This distributional pattern provides empirical evidence of an ‘Age of Prescriptivism’ in periodical reviewing, during which prescriptive discourses reached their zenith. Whilst the label ‘Age of Prescriptivism’ has been applied to a number of periods of English in recent decades, the findings reported here show clearly that the eighteenth century was the locus of prescriptive activity in the review periodical genre. The innovative application of corpus-based discourse-analytic methodologies for the identification of normative trends reported in this paper also has potential implications for studying prescriptivism as a sociohistorical linguistic phenomenon in other diachronic contexts.
Tailoring full-Stokes thermal emission from twisted-gratings structures
Authors: Yang Chiyu , Cai Wenshan , Zhang Zhuomin M. 
Published: October 2023

Abstract
Polarized thermal emission finds extensive applications in remote sensing, landmine detection, and target detection. In applications such as ellipsometry and biomedical analysis, the generation of emission with controllable polarization is preferred. It is desired to manipulate the polarization state over the full Stokes parameters. While numerous studies have demonstrated either linear or circular polarization control using metamaterials, full-Stokes thermal emission has not been explored. Here, a microstructure based on two layers of silicon carbide gratings is proposed to tailor the polarization state of thermal emission, covering the full-Stokes parameter range. The bilayer twisted-gratings structure breaks mirror symmetry. Wave interference at the interfaces and diffraction by the gratings enhance the emission dichroism, resulting in almost completely polarized emission. By adjusting the twist angle between the gratings, the polarization state can be continuously tuned from linear to circular, nearly covering the entire surface of Poincaré sphere. This study provides a design for tailoring full-Stokes emission with notable advantages over other plasmonic metasurfaces.
Single cell RNA sequencing – a valuable tool for cancer immunotherapy: a mini review
Authors: Kodous Ahmad S. , Balaiah Meenakumari , Ramanathan Priya 
Published: October 2023

Abstract
Single-cell RNA sequencing (scRNA-seq) technology has made great strides in research over the last decade. Data analysis has been aided by developments in bioinformatics tools and artificial intelligence, allowing biological and clinical researchers to get a deeper understanding of the different cell clusters and their dynamics within tumours. Combining conventional treatment modalities like chemotherapy and radiation with immunotherapy is a growing trend in cancer treatment. Hence, knowledge of the tumour microenvironment and the effect of each treatment modality on the TME, at a single cell level can provide treating clinicians with better clues for patient stratification and prognostication. With this knowledge, immunotherapy could become successful in treating a wide range of cancers, opening the path for the creation of even more effective treatment strategies. Despite the widespread availability of scRNA-seq technology, computational analysis and data interpretation are still challenges. Worldwide, such challenges are being addressed by various researchers, strengthening the contribution of this technology towards cancer elimination. In this mini-review, we primarily focus on the technique, its workflow, and the computational aspects of scRNA technology, along with an overview of the current challenges in the analysis and interpretation of the data generated.
Prediction of the rubberized concrete behavior: A comparison of gene expression programming and response surface method
Authors: Tufail Rana Faisal , Farooq Danish , Javed Muhammad Faisal , Mehmood Tahir , Maqsoom Ahsen , Ashraf Hassan , Deifalla Ahmed Farouk , Ahmad Jawad 
Published: October 2023

Abstract
The use of rubber in concrete to partially substitute mineral aggregates is an effort to decrease the global amount of scrap tires. This study investigates the behavior of rubberized concrete (RC) with various replacement ratios (0–50%) by volume and replacement type (fine, coarse, and fine-coarse) using soft computing techniques. The uniaxial compressive strength (CS), elastic modulus (EM), and ductility (D) are measured, and the effect of rubber content and the rubber aggregate type on the properties of RC is investigated. Scanning electron microscopy and X-ray diffraction analyses are made to determine its microstructural and chemical composition. This article compares the efficiency of two RC models using a recently developed artificial intelligence technique, i.e., gene expression programming (GEP) and conventional technique, i.e., response surface method (RSM). Statistical models are developed to predict the CS, TS, EM, and D. The mathematical models are validated using determination coefficient (R
2) and adjusted coefficient (R
2adj), and they are found to be significant. Furthermore, both methods (i.e., RSM and GEP) are very well correlated with the experimental data. The GEP is found to be more effective at predicting the experimental test results for RC. The projected methods can be executed for any practical value of RC.
The Burdened Body: Byzantine Enkolpia and the Weight of the Sacred
Authors: Drpić Ivan 
Published: October 2023

Abstract
Few products of human artistry seem as insistently concerned with self-representation as jewelry. In Georg Simmel’s classic formulation, articles of personal adornment work to enhance an individual’s social persona by magnifying their Ausstrahlung. While medieval Christian devotional jewels were well-equipped to operate in this manner, their true significance lay elsewhere. Objects such as pectoral crosses, reliquary rings, rosaries, and prayer nuts were designed not so much to mediate between self and society, but rather to stage and facilitate an encounter of the self with itself. Focusing on Byzantine devotional neck pendants, or enkolpia, this essay considers how religiously significant wearables participated in introspective spiritual practices aimed at forming and reforming the Christian subject. The essay, more specifically, attends to the enkolpion as an instrument of self-imposed discipline and explores how the corporeal experience of carrying this object and feeling its weight, however minimal, on the body contributed to the wearer’s cultivation of inner vigilance.
Marie-Antoinette and the Image of Moral Instruction
Authors: Lawrence Larkin T. 
Published: October 2023

Abstract
Long attributed to François-Hubert Drouais or his atelier, a three-quarter length portrait of Marie-Antoinette, together with a curiously inscribed frame, displayed in the lobby of the Hôtel Le Bristol, Paris, serves as a pretext for reconstructing the queen’s practice of gifting portraits of herself to members of her chapel. This essay explores Marie-Antoinette’s tendency in the early part of her reign to entrust the production of portraits to the Cabinet des tableaux. It argues on the basis of stylistic analysis that the Le Bristol portrait was probably the work of Jean-Martial Frédou and on the basis of iconographical analysis that it accommodated the quarrel between philosophes and clerics over reform of the Catholic Church in France, which made it suited to Monsignor du Chilleau, Bishop of Chalon.
Angular Head Velocity Cells within Brainstem Nuclei Projecting to the Head Direction Circuit
Authors: Graham Jalina A. , Dumont Julie R. , Winter Shawn S. , Brown Joel E. , LaChance Patrick A. , Amon Carly C. , Farnes Kara B. , Morris Ashlyn J. , Streltzov Nicholas A. , Taube Jeffrey S. 
Published: October 2023

The sense of orientation of an animal is derived from the head direction (HD) system found in several limbic structures and depends on an intact vestibular labyrinth. However, how the vestibular system influences the generation and updating of the HD signal remains poorly understood. Anatomical and lesion studies point toward three key brainstem nuclei as key components for generating the HD signal—nucleus prepositus hypoglossi, supragenual nucleus, and dorsal paragigantocellularis reticular nuclei. Collectively, these nuclei are situated between the vestibular nuclei and the dorsal tegmental and lateral mammillary nuclei, which are thought to serve as the origin of the HD signal. To determine the types of information these brain areas convey to the HD network, we recorded neurons from these regions while female rats actively foraged in a cylindrical enclosure or were restrained and rotated passively. During foraging, a large subset of cells in all three nuclei exhibited activity that correlated with the angular head velocity (AHV) of the rat. Two fundamental types of AHV cells were observed; (1) symmetrical AHV cells increased or decreased their firing with increases in AHV regardless of the direction of rotation, and (2) asymmetrical AHV cells responded differentially to clockwise and counterclockwise head rotations. When rats were passively rotated, some AHV cells remained sensitive to AHV, whereas firing was attenuated in other cells. In addition, a large number of AHV cells were modulated by linear head velocity. These results indicate the types of information conveyed from the vestibular nuclei that are responsible for generating the HD signal.SIGNIFICANCE STATEMENTExtracellular recording of brainstem nuclei (nucleus prepositus hypoglossi, supragenual nucleus, and dorsal paragigantocellularis reticular nucleus) that project to the head direction circuit identified different types of AHV cells while rats freely foraged in a cylindrical environment. The firing of many cells was also modulated by linear velocity. When rats were restrained and passively rotated, some cells remained sensitive to AHV, whereas others had attenuated firing. These brainstem nuclei provide critical information about the rotational movement of the head of the rat in the azimuthal plane.
SIRT2 negatively regulates the cGAS‐STING pathway by deacetylating G3BP1
Authors: Li Yutong , Bie Juntao , Song Chen , Li Yunfei , Zhang Tianzhuo , Li Haishuang , Zhao Long , You Fuping , Luo Jianyuan 
Published: October 2023

AbstractSIRT2, a cytoplasmic member of the Sirtuin family, has important roles in immunity and inflammation. However, its function in regulating the response to DNA virus infection remains elusive. Here, we find that SIRT2 is a unique regulator among the Sirtuin family that negatively modulates the cGAS‐STING‐signaling pathway. SIRT2 is down‐regulated after Herpes simplex virus‐1 (HSV‐1) infection, and SIRT2 deficiency markedly elevates the expression levels of type I interferon (IFN). SIRT2 inhibits the DNA binding ability and droplet formation of cGAS by interacting with and deacetylating G3BP1 at K257, K276, and K376, leading to the disassembly of the cGAS‐G3BP1 complex, which is critical for cGAS activation. Administration of AGK2, a selective SIRT2 inhibitor, protects mice from HSV‐1 infection and increases the expression of IFN and IFN‐stimulated genes. Our study shows that SIRT2 negatively regulates cGAS activation through G3BP1 deacetylation, suggesting a potential antiviral strategy by modulating SIRT2 activity.
Synergy of Reflection and Critical Thinking: a Catalyst for Students’ Intellectual Growth
Authors: Lionenko Mariia , Huzar Olena 
Published: October 2023

The article is dedicated to exploring the interaction between reflection and critical thinking in the context of developing students' intellectual abilities. Special attention is given to studying the impact of reflective practices on stimulating critical thinking in younger students and their ability to analyze and perceive information critically and objectively.
The article analyzes the fundamental aspects of reflective activities, including its role in developing students' consciousness, self-awareness, and internal processing of acquired information. The authors investigate various methods and techniques of reflection that educators can use to activate students' critical thinking. Specifically, the article offers practical case studies of implementing reflective approaches in the educational process.
The primary aim of the article is to raise educators' awareness of the significance of the interaction between reflection and critical thinking as key elements in students' intellectual development. The information presented in the article will contribute to the expansion of methodological foundations for promoting reflective processes in teaching and supporting the development of critical thinking among younger students. The research findings can be practically applied in educational institutions and contribute to improving the quality of education.
Muscarinic Receptors as Targets for Metronomic Therapy in Ovarian Cancer
Authors: SÖYLEMEZ Fatma , TÜRKSEVEN Çağatay Han 
Published: October 2023

Aim: In this study, the effects of muscarinic acetylcholine receptor (mAChR) agonist carbachol on the proliferation of cisplatin-resistant (A2780cis) and cisplatin-free (SKOV-3) ovarian cancer cell line were for the first time investigated to further evaluate the potential therapeutic effect of metronomic chemotherapy.
Material and Methods: The inhibitory effect of carbachol on cell proliferation was detected using the xCELLigence Real-Time Cell Analyzer (RTCA) dual plate (DP) system. A preliminary study was conducted to determine the dose of carbachol 100 µM, cisplatin 1 µM, and two combination studies were carried out with 100 µM carbachol + cisplatin 1 µM and 100 µM carbachol + 10 µM atropine, over cancer cells without drugs was used as the control group. The cell proliferation curve was monitored for 96 hours. The cell index value of inhibition in cell proliferation was automatically measured every hour for each well using RTCA 1.2.1 software.
Results: Co-administration of carbachol with cisplatin caused a decrease in cell number in both A2780cis and SKOV-3 cell lines in a time-dependent manner (p
Procesy kompensacyjne w rozwiązywaniu problemów społecznych
Authors: Słaboń Andrzej 
Published: October 2023

W artykule rozważa się rolę procesów kompensacyjnych w powstawaniu i rozwiązywaniu problemów społecznych. Kompensacja ujmowana jest zazwyczaj jako wyrównywanie deficytów różnych grup i środowisk społecznych. Kompensowanie nierówności przez politykę inkluzji staje się istotną cechą państwa bezpieczeństwa socjalnego. Procesy kompensacyjne rozumiane mogą być jednak szerzej jako reakcje podmiotów na dominujące cechy ładu społecznego. W tym kontekście wskazuje się na zachodzące kompensacje spontaniczne. Przejawem dominujących cech ładu społecznego jest zjawisko nadmiernej formalizacji oraz przeregulowanie życia społecznego prowadzące do różnych form sprzeciwu społecznego. Szeroko akcentowana polityka inkluzji wytwarza tendencje przeciwne o charakterze ukrytej ekskluzji. Rozwiązywanie wielu problemów społecznych polega w tym ujęciu na konwersji procesów spontanicznej kompensacji. Regulowanie tych procesów staje się elementem programu pozytywnej polityki społecznej.
Françoise Choay (1925)
Authors: Paquot Thierry , Ribeiro Peixoto Elane 
Published: October 2023

O artigo a seguir é uma biografia de Françoise Choay escrita por Thierry Paquot. Foi originalmente publicada em alemão em Frauen blicken auf die Stadt: architektinnen, planerinnen – Theoretikerinnen des Städtebaus II em 2019, em livro organizado por Katia Frey e Eliana Perrotti. A trajetória profissional de Françoise Choay, aqui contemplada, compreende sua formação, publicações e direção de coleções e seu papel na introdução de autores estrangeiros na França.
Frequency effects and the study of Limon’s Spanish copulas: ser and estar
Authors: Aguilar-Sánchez Jorge 
Published: October 2023

This paper presents a brief but comprehensive review of what has been done regarding the Spanish copula. It explores how frequency effects can help account for the unexplained variance found in the different proposed models, based on the Exemplar Model. This is done to propose a theoretical framework for the study of the Spanish copula in contact situations that include frequency as a variable to understand whether change is ongoing or stable, and whether the change of estar is extending to the contexts of ser, ser is extending to the contexts of estar, or both phenomena is taking place. I explore how each of the schema components interacts with each other, how these interactions fit into the traditional description of copula choice, and move away from the generative view of language as a set of rules to begin looking at it as a system highly affected by the frequency of use of its components. I then propose a procedure on how to explain copula behavior in Spanish that includes a multi-level analysis of this phenomenon.