bluuebunny/crossref_metadata_2025_split huggingface dataset:
The nature of tyrosine-aminated amyloid-β
Authors: Gao Zhonghong , Hu Ting , Wu Jinming , Fu Shitao , Li Hailing 
Published: January 2024

Abstract
Tyrosine residue in amyloid-β (Aβ) is susceptible to attack by various reactive nitrogen intermediates, leading to the formation of 3-nitrotyrosine (3-NT), a post-translational modification associated with the pathophysiology of Alzheimer's disease (AD). Although nitration was considered a "dead-end" product, emerging evidence suggests that 3-NT can be reduced to aminotyrosine in vivo. This study aims to validate the amination of Aβ tyrosine under physiological conditions and systematically investigate its impact on the aggregation and neurotoxicity of Aβ42. Our investigations reveal that tyrosine amination mitigates the highly ordered β-structure content of Aβ42, thereby modulating its aggregation pathway, which is primarily dominated by the multi-step secondary nucleation. Aminotyrosine fibrils exhibit enhanced fragmentation, increasing fibril elongation and insoluble aggregate production. Concurrently, tyrosine amination attenuates the neurotoxicity of Aβ42 by reducing intracellular reactive oxygen species (ROS) production and mitigating cell membrane disruption. Tyrosine amination substantially alters the aggregation and physiological properties of Aβ42. Nitration of Aβ42 and its subsequent conversion to tyrosine-aminated Aβ42 may represent an intrinsic defensive response against AD under nitrative stress.
Association of Body Mass Index with rapid eye movement sleep behavior disorder in Parkinson’s Disease
Authors: Gu Si-Chun , Yuan Xiao-Lei , Yin Ping , Li Yuan-Yuan , Wang Chang-De , Gu Min-Jue , Xu Li-Min , Gao Chen , Wu You , Hu Yu-Qing , Yuan Can-Xing , Cao Yang , Ye Qing 
Published: January 2024

Abstract
Background
The association between body mass index (BMI) and rapid eye-movement (REM) sleep-related behavioral disorder (RBD) in Parkinson’s disease (PD) remains unknown. Our study was to investigate the association of BMI with RBD in PD patients.
Methods
In this cross-sectional study, a total of 1115 PD participants were enrolled from Parkinson's Progression Markers Initiative (PPMI) database. BMI was calculated as weight divided by height squared. RBD was defined as the RBD questionnaire (RBDSQ) score with the cutoff of 5 or more assessed at baseline. Univariable and multivariable logistic regression models were performed to examine the associations between BMI and the prevalence of RBD. Non-linear correlations were explored with use of restricted cubic spline (RCS) analysis. And the inflection point was determined by the two-line piecewise linear models.
Results
We identified 426 (38.2%) RBD at baseline. The proportion of underweight, normal, overweight and obese at baseline was 2.61%, 36.59%, 40.36% and 20.44%, respectively. In the multivariate logistic regression model with full adjustment for confounding variables, obese individuals had an odds ratio of 1.77 (95% confidence interval: 1.21 to 2.59) with RBD compared with those of normal weight. In the RCS models with three knots, BMI showed a non-linear association with RBD. The turning points of BMI estimated from piecewise linear models were of 28.16 kg/m2, 28.10 kg/m2, and 28.23 kg/m2 derived from univariable and multivariable adjusted logistic regression models. The effect modification by depression on the association between BMI and RBD in PD was also found in this study. Furthermore, the sensitivity analyses linked with cognition, education, and ethnic groups indicated the robustness of our results.
Conclusion
The current study found a significant dose-response association between BMI and RBD with a depression-based difference in the impact of BMI on RBD in PD patients.
POT1 tumor predisposition: a broader spectrum of associated malignancies and proposal for additional screening program
Authors: Freitas Marta Baptista , Desmyter Laurence , Badoer Cindy , Smits Guillaume , Vandernoot Isabelle , de Roodenbeke Daphné t´Kint 
Published: January 2024

Abstract

Protection of Telomeres Protein 1 protein is an essential subunit of the shelterin telomere binding complex, regulating telomere length. Some POT1 gene pathogenic variants lead to telomere elongation and consequently genomic instability, which predisposes to a higher risk of cancer. POT1 tumour predisposition (POT1-TPD) is inherited in an autosomal dominant manner and it is related to an increased lifetime risk for cutaneous melanoma, chronic lymphocytic leukaemia (CLL), angiosarcoma (mostly cardiac angiosarcomas) and gliomas. In this work, we aim to describe a broader cancer phenotype related to POT1 tumour predisposition, in three different families. We performed genetic tests in 3 index cases identifying 3 different POT1 pathogenic variants: NC_000007.14(NM_015450.2):c.349C > T; NC_000007.14(NM_015450.2):c.233T > C and NC_000007.14(NM_015450.2):c.818G > A; already described in the literature. In total, thirty-four family relatives were tested and eighteen were positive. In these three families, it was possible to observe the typical POT1-TPD (cutaneous melanoma, cardiac angiosarcoma, chronic lymphocytic leukaemia and brain tumours). Nonetheless, these families present a higher incidence of other types of cancers: bone and soft tissue sarcomas, lung cancer, papillary thyroid cancer, early onset prostate cancer and leukaemia in association with POT1 pathogenic variants. These findings are important to better understand the implications of POT1 pathogenic variants, their prevalence, their penetrance and better characterize them. Furthermore, it can play an important role in future discussions about POT1 mutation screening criteria, improving genetic counselling of these patients and their families and also help to developed more accurate surveillance protocols for POT1 carriers.
Development and Psychometric Properties of a Lifestyle-Related Behaviors &amp; Barriers Scale (LBBS) among Young Adults
Authors: Ranjan Piyush , Anwar Wareesha , Malhotra Anita , Upadhyay Ashish , Kapoor Gautam , Verma Mehak , Singh Amandeep , Prakash Bindu , Deb Koushik , VIKRAM NAVAL 
Published: January 2024

Abstract

Background & Aim: The management of obesity has unique characteristics and challenges in different age groups. Effective redressal requires the recognition of unhealthy lifestyles through reliable and valid assessments targeting young adults (YAs). The present study is dedicated to formulating and evaluating the psychometric attributes of an all-encompassing questionnaire to assess lifestyle-related behavior and associated barriers.
Methods: The tool was formulated through a mixed-method study design, including item generation, assessment of content validity by experts, face validity through pre-testing, and construct validity through exploratory factor analysis (EFA). The dimensionality and discriminant validity were tested through structural equation modeling (SEM) by confirmatory factor analysis (CFA). Reliability, stability, and internal consistency were also confirmed by conducting a test-retest assessment using Cronbach’s alpha and Intraclass correlation (ICC).
Result: A tool with four latent factors and 17 items was found a good fit after EFA and subsequent CFA. A total of 302 participants were recruited for EFA, and 152 participants were subjected to SEM through CFA. Additional data from 102 participants was taken after one week for test-retest reliability. The tool demonstrated good reliability, stability, internal consistency (Cronbach’s alpha: .72, ICC= 0.960, CI= 0.952 to 0.971).
Conclusion: This study has successfully developed a concise and reliable questionnaire for assessing obesity-related factors in YAs, addressing the limitations of prior tools. The questionnaire holds promise for widespread use in clinical, research, and public health settings, facilitating assessments and interventions.
Quality and quantity of topsoil organic matter in monospecific and mixed pine forests: role of overstory and understory vegetation
Authors: López-Marcos Daphne , Turrión María-Belén , García-Duro Juan , Bravo Felipe , Martínez-Ruiz Carolina 
Published: January 2024

Abstract
Hypothesis and aims
The topsoil organic matter dynamics in mixed vs. monospecific pine stands responds to the vegetation composition. Thus, we tested the effect of the stand type and every under- and overstory species as well as the understory richness in forest floor and topsoil organic matter variability in a fine-scale approach.
Methods
The study of topsoil (5cm depth), forest floor (25 cm x 25 cm), understory (1 m x 1 m), and overstory (4 m radio) in 180 plots [6 triplets x 3 forest stands (PS: P. sylvestris monospecific stand; PP: P. pinaster monospecific stand; MM: mixed stand of both Pinus species) x 10 plots/stand] was implemented in a triplets’ essay in North-Central Spain.
Results
The topsoil organic matter quantity (~ TOC) described an expected trend given the overstory composition (PS > MM > PP) but quality (~ - C/N) showed an unexpected trend (PS ~ MM > PP) that we found related to the understory richness.
Conclusion
The quantity and quality of topsoil organic matter in mixed pine stands respond to the overstory, but also to the understory. Management strategies oriented to understory conservation to maintain dynamics of organic matter that promote carbon sequestration are recommended.
An updated method on the injectivity of integral operators related to Riemann Hypothesis
Authors: Adam Dumitru 
Published: January 2024

Abstract

A new theorem on the injectivity of the linear operators on separable Hilbert spaces is introduced, extending the Injectivity Criteria from [1]. The theorem stated: A linear bounded operator strict positive on a dense set of a separable Hilbert space, is injective.
Some observations regarding the analogy of the orthogonal projections defined by finite rank integral operators with the methods of the domain restriction to subspaces and Galerkin discretization are made: the matrix representations on the same subspaces differ only by normalisation factor introduced by the finite rank operator orthogonal projections. So, the new theorem will apply to the orthogonal projections by finite rank operators instead, for Galerkin and restriction method the Injectivity Criteria should be applied. Any of the methods used, provided the injectivity of the integral operator from the Alcantara-Bode equivalent formulation of the Riemann Hypothesis. As result, we claim that Riemann Hypothesis holds.
subjclass: 65R99, 47G10, 45P05
The effect of fluoroquinolones on the cancer development in patients with interstitial lung disease and virus infection
Authors: Yeh Jun-Jun , Sun Yi-Fan , Tang Hsien-Chin , Li Chia-Hsun , Kao Hsuan-Min , Lin Cheng-Li , Kao Chia-Hung 
Published: January 2024

Abstract

The virus increased risk of cancer and fluoroquinolones (FQs) could induce the interstitial lung disease (ILD) such as acute interstitial pneumonitis. The effects of FQs on the risk of cancer in patients having theILD concurrent with virus infection (ILD cohort) based on the International Classification of Diseases, Ninth Revision, Clinical Modification (ICD-9CM) is to be determined. The propensity score was calculated based on age, sex, index date, and medications of these comorbidities. Through the January 2000 to December 2013, the ILD cohort with FQs use (FQs cohort, N = 3,264) and those in the ILD cohort without FQs use (non-FQs cohort, N = 3,264) enter into study. Cox proportional regression with time-dependent exposure covariates was used to analyze the cumulative incidence of cancer. Adjusted hazard ratios (aHRs) and 95% confidence intervals (CIs) for cancer were determined after controlling for sex, age, medications (anti-inflammatory drugs, immunosuppressants), and comorbidities, as well as the use of FQs. Compared with the non-FQs cohort, the FQs cohort had aHRs (95% CIs) for cancer, colorectal cancer, lung cancer, and prostate cancer were 0.70 (0.59–0.83), 0.56 (0.37–0.85), 0.56 (0.38–0.85), and 2.39 (1.27–4.49) respectively. For patients with a single use of FQ>4≤ 15 days/ >15 days, the aHRs (95% CIs) were 0.50 (0.32–0.78)/1.83(0.71–4.70), 0.47 (0.31–0.73)/ 2.08 (0.97-4.48), and 1.94 (1.01–3.74)/ 12.1 (4.73–31.1) for colorectal, lung, and prostate cancers, respectively. The trend of the increase of the value of the aHR was found in these three cancers. For the patients with the cumulative daily dose FQ>4000mg ≤ 15 000mg/ >15 000mg, the similar trend was found also.Meanwhile, the use of FQs >4 ≤15 days (<cDDD, >4000mg ≤15000mg) was associated with a lower aHR for colorectal cancer and lung cancer in selected cases (drug sensitive). The use of the FQs >15 days(>cDDD15000 mg) was with a higher aHR for cancers such as prostate cancer (drug resistance). Perhaps, the FQs with drug sensitive for colorectal cancer and lung cancer may play an auxiliary role for prevention of these two cancers. Meanwhile, the FQs with drug resistance may not play a role for prevention of the prostate cancer. However, confounding factors such as drug resistance and a higher rate of medical services must be considered in the prostate cancer cohort.
Early diagnosis and surgical management of heterotopic pregnancy following in vitro fertilization-embryo transfer: A retrospective cohort study
Authors: He Jiajing , Shen Haofei , Wang Wei , Wang Lirong , Ma Xiaoling , Zhang Xuehong 
Published: January 2024

Abstract
Objective: The purpose of this study was to evaluate the efficacy of laparoscopic surgery for heterotopic pregnancy (HP), and to compare the clinical characteristics between HP, twin pregnancy and single pregnancy. The ROC curve was constructed to provide help for the early diagnosis of HP.
Design: This was a retrospective cohort study.
Setting: Reproductive Medicine Hospital of the First Hospital of Lanzhou.
Patients: Cases of HP (n=30), twin pregnancy (n=467) and single pregnancy (n=1127) were retrieved from the registry database.
Intervention: All patients diagnosed with HP underwent laparoscopic surgery.
Measurements: Clinical characteristics including age, body mass index (BMI), infertility type, menarche age, gravidity, parity, history of EP, number of retrieved oocytes, number of transferred embryos, surgery (initial symptom, EP site, surgical management), and pregnancy outcome (neonatal weight, live birth, miscarriage rate, preterm delivery rate) were recorded. Serum β-hCG, serum estradiol(E2) and serum progestin(P) were tested at 14 days after ET.
Main results: The live birth rate of HP was 66.6% and the miscarriage rate was 33.3%. Fourteen days after embryo transfer, the serum levels of β-human chorionic gonadotropin(β-hCG), estradiol(E2) and progestin(P) were lower in the HP group than in the twin pregnancy group(P<0.05). But there were no differences in the level of serum β-hCG, E2 between HP group and single group(P>0.05). The area under receiver operating characteristic (ROC) curve (AUC) of serum β-hCG-ET14d between HP and twin pregnancy were 0.80, 95% confidence interval (0.73-0.87), the cut-off value of β-hCG-ET14d was 1117 mIU/ml. The area under receiver operating characteristic (ROC) curve (AUC) of serum β-hCG-ET14d between HP and single pregnancy were 0.53, 95% confidence interval (0.44-0.62), the cut-off value of β-hCG-ET14d was 404.4 mIU/ml. The history of ectopic pregnancy in HP group was higher than that that in twin pregnancy group and single group (P <0.05). There were no differences in the intraoperative blood loss between live birth group and abortion group. The birth weight in HP group was similar with the single group(P>0.05), both all lower than the twin group(P<0.05).
Conclusion: This retrospective study suggested that a history of ectopic pregnancy may increase the risk of HP. β-hCG could not be an predictor for HP in the early stages. Intraoperative blood loss in laparoscopic surgery had no influence on the pregnancy outcomes.
CPI-613 Suppresses Pancreatic Cancer Stem-Like Cells by Targeting the SEMA3A/NRP1 Pathway
Authors: Li Zhuanghua , Xie Baocheng , Wu Peishan , Wang June , Liu Hongyu , Dong Zhuo , Huang Linxuan 
Published: January 2024

Abstract
Pancreatic cancer is known for its recurrence and chemotherapy resistance, partly attributed to cancer stem cells (CSCs). Targeting CSCs could improve the efficacy of standard cytotoxic therapies and potentially prevent or delay cancer recurrence. The increased reliance on the modulation of metabolic pathways in CSCs offers a potential therapeutic opportunity. In this study, we investigated the effects of CPI-613 (Dedvimistat), a metabolic inhibitor that targets the tricarboxylic acid cycle on pancreatic cancer cells. We demonstrate that treatment with CPI-613 significantly reduced the capacity to form CSCs, furthermore, CPI-613 showed decreased tumorigenicity in vivo. To gain further insights into the molecular mechanisms underlying the effects of CPI-613, RNA-Seq analysis was performed. CPI-613 impeded the unintended enrichment of CSC through target SEMA3A (Semaphorin 3A) and its receptor NRP1 (Neuropilin 1). Knockdown of SEMA3A significantly inhibited the proliferation of CD44 + frequency and increased their sensitivity to gemcitabine. Moreover, treatment with exogenous SEMA3A counteracted the inhibitory effect of CPI-613 on CSC proliferation and promoted resistance to gemcitabine. Our findings suggest that CPI-613 selectively targets pancreatic CSCs through the SEMA3A/NRP1 pathway. CPI-613 has the potential to overcome chemoresistance and prevent cancer recurrence by targeting CSCs.
Specific EEG resting state biomarkers in FXS and ASD
Authors: Proteau-Lemieux Mélodie , Knoth Inga Sophia , Davoudi Saeideh , Martin Charles-Olivier , Bélanger Anne-Marie , Fontaine Valérie , Côté Valérie , Agbogba Kristian , Vachon Keely , Whitlock Kerri , Biag Hazel Maridith Barlahan , Thurman Angela John , Rosenfelt Cory , Tassone Flora , Frei Julia , Capano Lucia , Abbeduto Leonard , Jacquemont Sébastien , Hessl David , Hagerman Randi Jenssen , Schneider Andrea , Bolduc Francois , Anagnostou Evdokia , Lippe Sarah 
Published: January 2024

Abstract

Background: Fragile X syndrome (FXS) and autism spectrum disorder (ASD) are neurodevelopmental conditions that often have a substantial impact on daily functioning and quality of life. FXS is the most common cause of inherited intellectual disability (ID) and the most common monogenetic cause of ASD. Previous literature has shown that electrophysiological activity measured by electroencephalogram (EEG) during resting state is perturbated in FXS and ASD. However, whether electrophysiological profiles of participants with FXS and ASD are similar remains unclear. The aim of this study was to compare EEG alterations found in these two clinical populations presenting varying degrees of cognitive and behavioral impairments.
Methods: Resting state EEG signal complexity, alpha peak frequency (APF) and power spectral density (PSD) were compared between 47 participants with FXS (aged between 5-20), 49 participants with ASD (aged between 6-17), and 52 neurotypical (NT) controls with a similar age distribution using one-way ANOVAs. ANCOVAs controlling for nonverbal intellectual quotient (NVIQ) scores were subsequently performed to determine the impact of cognitive functioning on EEG alterations.
Results: Our results showed that FXS participants manifested decreased signal complexity and APF compared to ASD participants and NT controls, as well as altered power in the alpha, beta, and low gamma frequency bands. ASD participants showed exaggerated beta power compared to FXS participants and NT controls, as well as enhanced low and high gamma power compared to NT controls. However, ASD participants did not manifest altered signal complexity or APF. Furthermore, when controlling for NVIQ, results of decreased complexity in higher scales and lower APF in FXS participants compared to NT controls and ASD participants were not replicated.
Conclusions: These findings suggest that signal complexity and APF might reflect cognitive functioning, while altered power in the low gamma frequency band might be associated with neurodevelopmental conditions, particularly FXS and ASD.
Environmental Considerations of Alternative Livelihoods for Women in Cocoa and Shea Communities in Ghana
Authors: Duorinaah Eric , Achanso Adams , Muntaka Hafix 
Published: January 2024

Abstract

Women in cocoa and shea communities have traditionally relied on the extraction of environmental resources for their livelihoods. Due to climatic, economic and social variabilities however, the traditional sources are no longer able to sustain their households and as a result, women are gradually up taking some alternative livelihood sources particularly during offseason. This study explored the effect of such alternative livelihood sources in the cocoa and shea communities on the physical environment. A case study design was employed for the study. In-depth interviews and focus group discussions were the main means for obtaining the requisite data from 131 respondents; 88.7% of whom were women drawn from ten communities in three regions in five geographic districts in Ghana. The study revealed that about eighteen alternative livelihood sources pursued by women were key in providing the needs of most households and their effect on the physical environment was negligible. The exceptions were vegetable cultivation, guinea fowl rearing and dawadawa processing in some communities which recorded appreciable negative effect largely due to poor management practices. The study recommended that, to improve and sustain the quality of the environment, there was the need for proper waste disposal practices and the enforcement of policies and laws that prohibit the use of pesticides and other harmful chemicals used in the alternative livelihood activities.
Positive Psychology in Language Teaching: Investigating Factors Influencing Women Language Teacher Well-being under the "UP or Out" Policy
Authors: Qu Kunyang , Wu Xuande 
Published: January 2024

Abstract
The psychological well-being of educators is imperative, especially when navigating complex career dynamics such as China's "up or out" policy. This research investigates the well-being of women L2 teachers across various Chinese educational institutions. Utilising a multiple linear regression model, the study unpacks relationships between system-related teacher anger, work engagement, teaching enjoyment, job satisfaction, emotion regulation behaviour, and overall psychological health. The result shows a strong positive link between work engagement and emotion regulation behaviour. Moreover, job satisfaction is pivotal to emotion regulation and psychological well-being. By highlighting the profound influence of emotion regulation, this study provides essential insights into China's unique educational context. The results offer valuable directives for policymaking, educator training, and institutional practices, all aiming to fortify the psychological well-being of L2 teaching professionals.