bluuebunny/crossref_metadata_2025_split huggingface dataset:
A self‐adaptive, data‐driven method to predict the cycling life of lithium‐ion batteries
Authors: Han Chao , Gao Yu‐Chen , Chen Xiang , Liu Xinyan , Yao Nan , Yu Legeng , Kong Long , Zhang Qiang 
Published: January 2024

AbstractAccurately forecasting the nonlinear degradation of lithium‐ion batteries (LIBs) using early‐cycle data can obviously shorten the battery test time, which accelerates battery optimization and production. In this work, a self‐adaptive long short‐term memory (SA‐LSTM) method has been proposed to predict the battery degradation trajectory and battery lifespan with only early cycling data. Specifically, two features were extracted from discharge voltage curves by a time‐series‐based approach and forecasted to further cycles using SA‐LSTM model. The as‐obtained features were correlated with the capacity to predict the capacity degradation trajectory by generalized multiple linear regression model. The proposed method achieved an average online prediction error of 6.00% and 6.74% for discharge capacity and end of life, respectively, when using the early‐cycle discharge information until 90% capacity retention. Furthermore, the importance of temperature control was highlighted by correlating the features with the average temperature in each cycle. This work develops a self‐adaptive data‐driven method to accurately predict the cycling life of LIBs, and unveils the underlying degradation mechanism and the importance of controlling environmental temperature.image
Three‐dimensional (3D) polylactic acid gradient scaffold to study the behavior of osteosarcoma cells under dynamic conditions
Authors: De Luca Angela , Capuana Elisa , Carbone Camilla , Raimondi Lavinia , Carfì Pavia Francesco , Brucato Valerio , La Carrubba Vincenzo , Giavaresi Gianluca 
Published: January 2024

AbstractThis study adopts an in vitro method to recapitulate the behavior of Saos‐2 cells, using a system composed of a perfusion bioreactor and poly‐L‐lactic acid (PLLA) scaffold fabricated using the low‐cost thermally‐induced phase separation (TIPS) technique. Four distinct scaffold morphologies with different pore sizes were fabricated, characterized by Scanning electron microscopy and micro‐CT analysis and tested with osteosarcoma cells under static and dynamic environments to identify the best morphology for cellular growth. In order to accomplish this purpose, cell growth and matrix deposition of the Saos‐2 osteosarcoma cell line were assessed using Picogreen and OsteoImage assays. The obtained data allowed us to identify the morphology that better promotes Saos‐2 cellular activity in static and dynamic conditions. These findings provided valuable insights into scaffold design and fabrication strategies, emphasizing the importance of the dynamic culture to recreate an appropriate 3D osteosarcoma model. Remarkably, the gradient scaffold exhibits promise for osteosarcoma applications, offering the potential for targeted tissue engineering approaches.
VEGF‐delivering PEG hydrogels promote vascularization in the porcine subcutaneous space
Authors: Quizon Michelle J. , Deppen Juline N. , Barber Graham F. , Kalelkar Pranav P. , Coronel María M. , Levit Rebecca D. , Garcia Andres J. 
Published: January 2024

AbstractFor cell therapies, the subcutaneous space is an attractive transplant site due to its large surface area and accessibility for implantation, monitoring, biopsy, and retrieval. However, its poor vascularization has catalyzed research to induce blood vessel formation within the site to enhance cell revascularization and survival. Most studies focus on the subcutaneous space of rodents, which does not recapitulate important anatomical features and vascularization responses of humans. Herein, we evaluate biomaterial‐driven vascularization in the porcine subcutaneous space. Additionally, we report the first use of cost‐effective fluorescent microspheres to quantify perfusion in the porcine subcutaneous space. We investigate the vascularization‐inducing efficacy of vascular endothelial growth factor (VEGF)‐delivering synthetic hydrogels based on 4‐arm poly(ethylene) glycol macromers with terminal maleimides (PEG‐4MAL). We compare three groups: a non‐degradable hydrogel with a VEGF‐releasing PEG‐4MAL gel coating (Core+VEGF gel); an uncoated, non‐degradable hydrogel (Core‐only); and naïve tissue. After 2 weeks, Core+VEGF gel has significantly higher tissue perfusion, blood vessel area, blood vessel density, and number of vessels compared to both Core‐only and naïve tissue. Furthermore, healthy vital signs during surgery and post‐procedure metrics demonstrate the safety of hydrogel delivery. We demonstrate that VEGF‐delivering synthetic hydrogels induce robust vascularization and perfusion in the porcine subcutaneous space.
Prostatic morphological changes throughout life: Cytochemistry as a tool to reveal tissue aging markers
Authors: Guerra Luiz Henrique Alves , Campos Silvana Gisele Pegorin , Taboga Sebastião Roberto , Vilamaior Patricia Simone Leite 
Published: January 2024

AbstractThe prostate undergoes normal or pathological morphological changes throughout life. An understanding of these changes is fundamental for the comprehension of aging‐related pathological processes such as benign prostatic hyperplasia (BPH) and cancer. In the present study, we show some of these morphological changes, as well as histochemical techniques like Weigert's resorcin‐fuchsin method, Picrosirius Red, and Gömöri's reticulin for use as tools in the study of prostate tissue under light microscopy. For this purpose, prostates of the Mongolian gerbil (n = 9), an experimental model that develops BPH spontaneously, were analyzed at three life stages: young (1 month old), adult (3 months old), and old (15 months old). The results showed that fibrillar components such as collagen, and reticular and elastic fibers, change throughout life. In young animals, the prostate has cuboidal epithelium surrounded by thin layers of smooth muscle, continuous collagen fibers, winding reticular fibers, and sporadic elastic fibers. With adulthood, the epithelium becomes columnar, encircled by compacted muscle cells among slender collagen fibers, elongated reticular fibers, and linear elastic fibers. In aging individuals, the prostate's epithelium stratifies, surrounded by thick muscle layers among dense collagen fibers, disordered reticular fibers, and elastic fibers in different planes. We also identified a few accumulations of lipid droplets and lipofuscin granules in adult animals and high accumulation in old animals evidenced by Oil red O and Gömöri‐Halmi techniques, respectively. The histochemical techniques presented here have been demonstrated to be useful and accessible tools in prostate studies.Research Highlights
Cytochemical techniques to study prostate morphology.
The prostate changes with age.
Homogenization of German daily and monthly mean temperature time series
Authors: Kunert Lisa , Friedrich Karsten , Imbery Florian , Kaspar Frank 
Published: January 2024

AbstractLong time series can be potentially influenced by breakpoints. This study presents an automatic procedure to detect and homogenize breakpoints in German daily and monthly mean temperature time series. To verify breakpoints metadata information is used. The homogenization tool is evaluated with a synthetic data set with the result of smaller mean bias and RMSE than the unhomogenized data. For homogenized German temperature data in most cases, smaller and less breakpoints are detected compared to the raw data. The mean differences of trends before and after homogenization is small (0.05 K/length of each time series). The result of the homogenization is presented in three case studies. After homogenization, the trend in these cases is closer to the calculated trend for Germany calculated using a gridded data set.
Using social media for patient care, research, and professional development: A North American Society of Pediatric Gastroenterology, Hepatology, and Nutrition position paper
Authors: Silverman Jason A. , Chugh Ankur , Hollier John M. , Martin Nicole , Raghu Vikram K. , Rosas‐Blum Eduardo , van Tilburg Miranda A. L. , Venkataraman‐Rao Priya , Venkatesh Rajitha D. , Lu Peter L. 
Published: January 2024

AbstractThe advent of social media has changed numerous aspects of modern life, with users developing and maintaining personal and professional relationships, following and sharing breaking news and importantly, searching for and disseminating health information and medical research. In the present paper, we reviewed available literature to outline the potential uses, pitfalls and impacts of social media for providers, scientists and institutions involved in digestive health in the domains of patient care, research and professional development. We recommend that these groups become more active participants on social media platforms to combat misinformation, advocate for patients, and curate and disseminate valuable research and educational materials. We also recommend that societies such as NASPGHAN assist its members in accessing training on effective social media use and the creation and maintenance of public‐facing profiles and that academic institutions incorporate substantive social media contributions into academic promotion processes.
Thermal‐Triggered Phase Separation and Ion Exchange Enables Photoluminescence Tuning of Stable Mixed‐Halide Perovskite Nanocrystals for Dynamic Display
Authors: Li Xinkuo , Sun Ke , Wu Jiajia , Liu Yi , Li Linhan , Xiao Zhu , Li Zhou , Liu Xiaofeng , Xu Beibei , Qiu Jianrong , Tan Dezhi 
Published: January 2024

AbstractFlexible regulation of bandgap of perovskite nanocrystals (PNCs) is fundamentally critical for desirable optoelectronic functions and applications. Here, regulating chemical composition and emission wavelength of PNCs in glass by a simple heat‐treatment process are reported, which is established to rely on the thermal‐trigger phase separation and ion exchange. The first principle calculations are overall performed to reveal the mechanism of bandgap engineering and optimization of emission performance. The PNCs exhibit excellent stability against thermal, ultraviolet irradiation, and organic molecules. The bandgap of PNCs in the heat‐treated glass can also be re‐modulated by ultrafast laser irradiation. Ultrafast laser direct writing of multi‐color patterns and holographic dynamic displays are achieved, which hold great potential in the application of encryption‐decryption and emissive devices.
Highly efficient electrocatalysts for seawater electrolysis under high current density: A critical review
Authors: Kitiphatpiboon Nutthaphak , Chen Meng , Feng Changrui , Li Shasha , Abudula Abuliti , Guan Guoqing 
Published: January 2024

AbstractAccording to the International Energy Agency (IEA) strategy, water electrolysis will be a second priority for hydrogen production by 2030, which can support sustainable development goals (SDGs). However, for the large‐scale application, especially seawater electrolysis at a high current density, cost and durability of the electrocatalytic system need to be taken into account. Herein, fundamental mechanisms of seawater electrolysis in a wide range of pH values, potential electrocatalysts for overall water splitting, recent progress on synthesis electrocatalysts and basic principles for the evaluation of electrocatalysts are reviewed. Subsequently, critical parameters and issues for scaling‐up of seawater electrolyzers are critically discussed. Finally, future prospects for completing sustainable hydrogen production from seawater for sustainable development are outlooked. It is anticipated to offer guidelines for the design and production of innovative electrocatalysts with high electrocatalytic activity and durability for the industrial scale application.
Prevalence of anterior atlantoaxial subluxation and association with established rheumatoid arthritis
Authors: Alp Gülay , Cinakli Haluk , Akar Servet , Solmaz Dilek 
Published: January 2024

AbstractObjectiveSpinal involvement in rheumatoid arthritis (RA) is limited to the upper cervical spine, leading to cervical spine instability. This study aimed to evaluate the prevalence of anterior atlantoaxial subluxation (aAAS) and its associated risk factors in patients with RA.MethodThis single‐centre cross‐sectional study 240 patients consecutively were recruited. Radiographs of the cervical spine were obtained in the flexion and neutral neck positions and read by two blinded observers. The diagnosis of aAAS was based on the distance between the anterior aspect of the dens and the posterior aspect of the anterior arch of the atlas, which was >3 mm during flexion. Statistical analysis was performed to determine the predictive factors of aAAS.ResultsTwo hundred and forty patients with a mean ± SD age of 56.4 ± 11.4 years were recruited, and 191 (78%) were female. The mean ± SD duration of the disease was 10.2 ± 8.5 years. Of all 25 cases (10.4%) diagnosed with aAAS, the mean anterior atlantodental interval in patients with AAS was 4.19 ± 1.20 mm. One in three patients with aAAS had no neck pain. Patients with aAAS had longer disease duration, lower age at diagnosis, lower body mass index, higher anti‐cyclic citrullinated peptide autoantibodies (anti‐CCP), more frequent erosion, joint restriction, and joint prostheses. In the multivariate regression model, joint limitation, history of joint prostheses, low BMI, and higher anti‐CCP levels were independent predictors of the aAAS.ConclusionThirty‐three percent of patients with cervical involvement do not experience neck pain. Cervical involvement should be considered even without neck pain, particularly in established diseases.
A phase 1 trial utilizing a pharmacokinetic endpoint to determine the optimal dose of ramucirumab in children and adolescents with relapsed or refractory solid tumors, including central nervous system tumors
Authors: Pilbeam Kristy L. , Pradhan Kamnesh , Croop James , Minard Charles G. , Liu Xiaowei , Voss Stephan D. , Isikwei Emasenyie , Berg Stacey L. , Reid Joel M. , Fox Elizabeth , Weigel Brenda J. 
Published: January 2024

AbstractBackgroundRamucirumab is a monoclonal antibody that binds the extracellular domain of vascular endothelial growth factor receptor (VEGFR‐2) and prevents binding of VEGF ligands. Based on population pharmacokinetic (PK) analysis and correlation with efficacy in adults, a target steady state trough concentration (Css,min) ≥ 50 µg/mL was established.ProceduresThis phase 1 trial (ADVL1416) used a rolling six design and a PK primary endpoint to define the recommended phase 2 dose (RP2D) of ramucirumab in children with recurrent/refractory solid tumors. Two dose levels (DL) were planned (DL1: 8 mg/kg, DL2: 12 mg/kg administered intravenously [IV] every 2 weeks). Toxicity during the initial 6 weeks was used to assess maximum tolerated dose (MTD). Cycle 1 Day 42 trough (Cmin) ≥ 50 µg/mL was the target concentration for the PK endpoint. At the RP2D, cohorts for PK expansion and children with central nervous tumors were planned.ResultsTwenty‐nine patients were enrolled; 28 were eligible; median age [range] = 13.5 [1–21] years; 22 were evaluable for the PK endpoint. Dose‐limiting proteinuria occurred at both DLs; however, the MTD was not exceeded. At DL2 (12 mg/kg), the median Day 42 Cmin (n = 16) was 87.8 µg/mL; 15 of 16 patients achieved a Cmin ≥ 50 µg/mL.ConclusionRamucirumab was well tolerated in children and adolescents with solid tumors. The RP2D for ramucirumab was 12 mg/kg IV every 2 weeks. This trial demonstrates the feasibility of incorporating a primary PK endpoint to determine dose escalation and the RP2D in children. Studies of ramucirumab in children with selected solid tumors are ongoing.
Changes in the astronaut serum proteome during prolonged spaceflight
Authors: Kimura Yayoi , Nakai Yusuke , Ino Yoko , Akiyama Tomoko , Moriyama Kayano , Aiba Tatsuya , Ohira Takashi , Egashira Kenji , Yamamoto Yu , Takeda Yuriko , Inaba Yutaka , Ryo Akihide , Saito Tomoyuki , Kumagai Ken , Hirano Hisashi 
Published: January 2024

AbstractThe molecular mechanisms associated with spaceflight‐induced biological adaptations that may affect many healthy tissue functions remain poorly understood. In this study, we analyzed temporal changes in the serum proteome of six astronauts during prolonged spaceflight missions using quantitative comprehensive proteome analysis performed with the data‐independent acquisition method of mass spectrometry (DIA‐MS). All six astronauts participated in a spaceflight mission for approximately 6 months and showed a decreasing trend in T‐scores at almost all sites where dual‐energy X‐ray absorptiometry scans were performed. DIA‐MS successfully identified 624 nonredundant proteins in sera and further quantitative analysis for each sampling point provided information on serum protein profiles closely related to several time points before (pre‐), during (in‐), and after (post‐) spaceflight. Changes in serum protein levels between spaceflight and on the ground suggest that abnormalities in bone metabolism are induced in astronauts during spaceflight. Furthermore, changes in the proteomic profile occurring during spaceflight suggest that serum levels of bone metabolism‐related proteins, namely ALPL, COL1A1, SPP1, and POSTN, could serve as highly responsive indicators of bone metabolism status in spaceflight missions. This study will allow us to accelerate research to improve our understanding of the molecular mechanisms of biological adaptations associated with prolonged spaceflight.
TATB thermal decomposition: Expanding the molecular profile with cryo‐focused pyrolysis GC‐MS
Authors: Morrison Keith D. , Moore Jason S. , Coffee Keith R. , Koroglu Batikan , Burnham Alan K. , Reynolds John G. 
Published: January 2024

AbstractUnderstanding the molecular composition of high explosives during thermal decomposition is vital for predicting the sensitivity, safety, and performance of explosive materials. The thermal decomposition of 1,3,5‐triamino‐2,4,6‐trinitrobenzene (TATB) has been linked to the formation of furazans through a series of dehydration reactions of the NO2 and NH2 groups on the phenyl ring, along with breakdown into small molecules (≤120 amu). Molecular identification of compounds formed in this transformation of the furazans to light gases has been lacking. To address this, we have applied a pseudo‐confined sampling system in a cryo‐focused pyrolysis gas chromatography‐mass spectrometry (pyGC‐MS) system to molecularly identify these intermediates. By design, sublimation of TATB, which has complicated MS analyses of thermal degradation, was significantly reduced and additional compounds were identified with potential structural information. In addition to the known furazan compounds, one of these compounds forms from the loss of oxygen from benzo‐trifurazan (F3) and produces an open ring structure that may be the first step in the formation of lower molecular weight furazan breakdown products. The loss of a nitro group from benzo‐monofurazan (F1) was also discovered and implicates the formation of oxidizing NO2 gas in the thermal decomposition mechanism. These findings are vital for understanding the proper heat flow from energetic materials on a molecular level, necessary when measuring enthalpy and developing decomposition models based on kinetic parameters.
Exploring Late‐Time Cosmic Acceleration with Eos Parameterizations in Horava‐Lifshitz Gravity via Baryon Acoustic Oscillations
Authors: Khurana Madhur , Chaudhary Himanshu , Debnath Ujjal , Sardar Alok , Mustafa Ghulam 
Published: January 2024

AbstractIn this study, the framework of Horava‐Lifshitz gravity to model the Universe's dark matter and dark energy (DE) components is adopted. Specifically, two recent parametrizations for DE models: the CBDRM‐type and CADMM‐type parameterizations is considered. In the analysis, the Hubble parameter is explicitly expressed, denoted as , for these two distinct dark energy models. By doing so, investigate and quantify the accelerated cosmic expansion rate characterizing the late‐time Universe is aimed. This study uses a wide range of datasets. This dataset consists of recent measurements of baryon acoustic oscillations (BAOs) collected over a period of 22 years with the Cosmic Chronometers (CC) dataset, Type Ia supernovae (SNIa) dataset, the Hubble diagram of gamma‐ray bursts (GRBs), quasars (Q), and the latest measurement of the Hubble constant (R22). Consequently, a crucial aspect of this study by plotting the vs. H0 plane is presented. In the context of the ΛCDM model, after incorporating all the datasets, including the R22 prior, the following results: H0 = 71.674089 ± 0.734089 and is obtained. For the CBDRM model, H0 = 72.355058 ± 1.004604 and is found. In the case of the CADMM model, the analysis yields H0 = 72.347804 ± 0.923328 and . Cosmographic analyses for both of the proposed parameterizations in comparison to the ΛCDM paradigm are conducted. Additionally, Diagnostic tests to investigate the evolution of both models is applied. Finally, the Information Criteria test demonstrates that the ΛCDM model emerges as the preferred choice among the models is considered.
Grid‐based assessment of hydrogen leakages for an offshore process to improve the design and human performance
Authors: Malik Asher Ahmed , Rusli Risza , Nazir Salman , Wong Rizal Harris , Arshad Ushtar 
Published: January 2024

AbstractHydrogen is gaining global recognition as a sustainable energy source, but its combustible nature raises concerns, especially in congested offshore settings. Steam methane reforming (SMR) remains the predominant hydrogen production method; however, offshore SMR facilities exposed to harsh weather could potentially compromise safety because of leakages. This study uses the fire dynamics simulator (FDS) to carry out the first‐of‐its‐kind CFD modeling of hydrogen leakage and its wind‐influenced dispersion on an offshore SMR platform. It also provides the spatial risk that accounts for the probabilities of human errors and wind speeds. The study uses a grid‐based approach with 120 monitor points (MPs) to measure locally dispersed gas concentration. At 2 m/s wind speed, only nine grids contain explosive concentrations while the rest remain safe. At 5 m/s, the flammable zones increase by 133%, affecting 21 grids. Extreme wind speeds of 12.5 m/s have limited impact, but SMR1 exhibits higher stoichiometric concentrations. MPs 43–48 record flammable concentrations at all wind speeds; however, at 12.5 m/s the explosion risk is well below the threshold of 1 × 10−4 due to the low wind occurrence probability. Overall, this research contributes to addressing the safety concerns associated with hydrogen in offshore settings and provides a foundation for future risk assessments.