bluuebunny/crossref_metadata_2025_split huggingface dataset:
Perioperative tislelizumab plus chemotherapy for locally advanced resectable thoracic oesophageal squamous cell carcinoma trail: A prospective single-arm, phase II study (PILOT trial)
Authors: Ding Chengzhi , Guo Yijun , zhou Yaning , He Yi , Chen Chunji , Zhang Ming , Guo Xufeng 
Published: October 2023

Abstract
Background
The promising therapeutic outcomes of neoadjuvant immunotherapy combined with chemotherapy in the treatment of locally advanced esophageal squamous cell carcinoma (ESCC) have been confirmed by several phase Ⅱ clinical trials and have been widely used in clinical work. Theoretically, postoperative adjuvant immunotherapy may further improve the therapeutic effect, but there is still lack of evidence. The aim of this study was to analyze the safety and efficacy of perioperative immunotherapy (tislelizumab) for locally advanced resectable thoracic ESCC (PILOT trial).
Methods
Seventy-three eligible patients with pathologically confirmed thoracic ESCC at clinical T1b-3N1-3M0 or T3N0M0 staging will be allocated to receive neoadjuvant immunotherapy (tislelizumab 200mg d1, q3w × 2 cycles) plus chemotherapy (nad-paclitaxel 260 mg/m2 d1 + carboplatin AUC = 5 d1, q3w × 2 cycles) treatment. Patients with pathologic complete response (pCR) after esophagectomy received adjuvant tislelizumab (200 mg every 3 weeks up to one year), and patients with non-pCR were assigned adjuvant tislelizumab plus chemotherapy for two cycles and then maintenance tislelizumab (200 mg every 3 weeks up to 15 cycles). The primary endpoint of this study is 2-year disease-free survival (DFS) in non-pCR patients. The secondary endpoints include pCR rate, major pathological response rate, 2-year DFS in pCR patients, R0 resection rate, adverse events, and overall survival.
Discussion
This protocol has been reviewed and approved by the Ethics Committee of Shanghai Chest Hospital (IS23059). This is the first prospective clinical trial to investigate the safety and efficacy of perioperative immunotherapy for locally advanced resectable thoracic ESCC. We hypothesize that perioperative immunotherapy could be a promising therapeutic strategy which can provide better 2-year DFS in non-pCR patients.
Trial registration
ClinicalTrial.gov: NCT0605633
Polypharmacy and drug interactions in older patients with cancer receiving chemotherapy: associated factors
Authors: Oliveira Rita Ferraz , Oliveira Ana I. , Cruz Agostinho S. , Ribeiro Oscar , Afreixo Vera , Pimentel Francisco 
Published: October 2023

Abstract

Background Polypharmacy in older adults with cancer receiving chemotherapy leads to increased risks of drug interactions, translating in potential hazardous health outcomes. This study aims to assess the prevalence of polypharmacy, drug–drug interactions (DDIs), and severe-drug interactions (SDIs) in older patients with cancer. Antineoplastic agents (ANAs) involvement and possible risk contexts (comorbidities with cardiac risk, and high-risk medications) were also analysed. Methods Observational study with older adults (≥ 65 years) diagnosed with cancer, who were treated with antineoplastic agents (ANAs); it was conducted in three hospitals from the north of Portugal. Data collection was obtained using self-reports and medical records. DDIs were identified and classified using Micromedex® software. Descriptive and association analyze statistics were performed. Statistical hypothesis tests with p value less than 0.05 were considered significant. All statistical procedures and analysis were performed with R version 4.1.3. Results We enrolled 552 patients. Polypharmacy prevalence was 88.40%; 76.45% and 56.16% of the patients presented with DDIs and SDIs, respectively. SDIs with ANAs were identified in 21.20% of the patients. High-risk medications were associated with a higher risk of polypharmacy, DDIs, and SDIs. Polypharmacy and DDIs were higher in patients with hypertension or diabetes. SDIs were higher in patients with diabetes. Conclusion Polypharmacy, potential DDIs and SDIs were highly prevalent in older adults with cancer. A careful review of the medication administered is necessary to decrease it. These findings warrant further research to optimize medication in this population and decrease problems related to medication, that may lead to emergency room visits and hospitalisations, compromising patient safety and/or ongoing treatments.
Geometric error compensation method using the Laser R-test
Authors: Hsieh Tung Hsien , JYWE WEN-YUH , ZENG JHENG-JHONG , HSU CHIA-MING , CHANG YU-WEI 
Published: October 2023

Abstract
Regarding the precision of the five-axis machine tool, it is found that 70% of its error is derived from the rotational axis PIGEs and PDGEs. At present, the measurement of these errors is required to be conducted by instruments such as interferometers, DBB, IBS, etc., which are considered expensive and time-consuming. In this research, the development of a contactless calibration tool system, which is designed to measure all 43 items of PIGEs and PDGEs in the five-axis machine tool, is pursued. The calibration tool, named “Laser R-Test” and developed since 2000, is recognized as being capable of analyzing the eccentricity error (XOC,YOC,ZOA,YOA) and angular position error (ECC,EAA). Moreover, the five-axis simultaneous trajectory error can be measured. Through extensive research, it has been determined that the total error in a five-axis machine tool can be controlled to below 40 um after compensating for two error parameters. However, achieving a total error below \(\pm\)10 um remains elusive. This limitation is attributed to the presence of wobble error (such as AOC, BOC, AOB, COB) in the rotary axis orientation, and the analysis and compensation for the rotary axis have yet to be achieved. In this study, a methodology based on Laser R-test and Rodrigues' rotation formula was developed to establish a PIGEs error model. The path XYZ errors were obtained through a simplified path combined with the Laser R-Test. By having the XYZ errors from each point in the path inputted into the model, the current errors and compensation values of the machine tool were determined. The analysis and compensation of 8 PIGEs errors in the rotary axis were completed in 30 minutes using the inspection path. Ultimately, the system's compatibility with K1, K2, and K4 path tests, as prescribed by ISO-10791-6, was ensured, validating the compensation effects on various parameters. A precision below \(\pm\)10 um was achieved, and the inspection time was reduced by over 50%. Then, by integrating the results of previous related studies, this system and method can complete multiple error detections, including angular positioning errors [13], eccentricity errors [11], and wobble errors, by simply using different paths. This greatly reduces the setup time for future users, enhancing its commercial applicability.
Liver injury in non-severe COVID-19 with various pandemic phases: a real-world study
Authors: Winyupakorn Jirayuth , Sangketchon Chunlanee , Ayutthaya Watcharaporn Devakul Na , Sethasine Supatsri 
Published: October 2023

Abstract
The using of a variety of anti-COVID-19 medicines connected to the degree of liver impairment in the short term was intriguing. To evaluate the dynamic course of liver injury in patients with mild to moderate COVID-19 within 10 days of admission. This was a prospective cohort study of 300 patients who were newly proven mild to moderate COVID-19 between September 2021 and October 2022. There were 188 patients in hospitel/field hospital (n = 188) and cohort wards (n = 112). One hundred and fifteen patients (38.3%) suffered from liver injury (LI). The majority of Group LI participants (n = 104) received medication to treat the COVID-19 infection, including favipiravir (45%), remdesivir (17.4%), molnupiravir (11.3%), Andrographis paniculata (ADG) (8.7%), and favipiravir in combination with ivermectin (7.7%). When compared to no LI, molnupiravir medication was linked with the largest proportion of transaminase < 2 and 2–5 times the ULN [11.3% vs. 4.9%, p = 0.038; 15.2% vs. 4.9%, p = 0.013]. After 10 days, the majority of patients exhibited a transaminase decline. A less-than-critical level of liver damage was reported in mild to moderate COVID-19 that allows clinicians to administer a variety of standard medications during short periods of hospital stay.
Measuring the Effectiveness of E-mail Marketing on Youth Purchase Intention in Puducherry Toward Branded Apparel
Authors: A Datchayai , V.Vasikar  
Published: October 2023

Abstract
This article addresses the effectiveness of e-mail marketing on the youth purchase intention of consumers towards branded apparel in Puducherry and also reveals the satisfaction level of e-mail content should be valued by consumers. Data were collected from 300 youth consumers based on a convenient sampling method. This research conceptualizes the four variables of consumer intention of their email marketing journey on permission-based marketing, e-mail advertising, digital newsletter, and standalone campaigns from the apparel brand. The result reveals that e-mail marketing has positive effects on the consumer's purchase intention towards branded apparel. Digital newsletter influences consumers to buy the product online followed E-mail advertising. Consumers are revealed to e-mail marketing and suggest the branded apparel to their friends and family. This study encourages marketers to maintain relationships with customers frequently through electronic mail to enhance consumer purchase intention.
An empirical study on the influencing factors of patented technology transfer prices in Universities——Evidence from 10 key universities in China
Authors: Chen Qinqin , Wang Chaoyi , Hui Yuji , Zhang Sheng 
Published: October 2023

Abstract
The successful transformation of science and technology (S&T) achievements is relies on the evaluation of their value by the stakeholders in the S&T market. Both excessively high prices set by the patent holder and excessively low prices offered by potential buyers can hinder the successful transfer of S&T achievements. This study, based on the Triple Helix Innovation Theory and Technology Transfer Theory, empirically examines the factors that influence the price of patent technology transfer, using a sample of 10 key Chinese universities from 2018 to 2022. Research found that the inherent quality of patents and the external market environment both have a positive and significant impact on the price of patented technology transfer in universities. Furthermore, government support plays a significant role in moderating the effect of patent quality and market transaction factors on the price of patent technology transfer in universities. Additionally, there is industry heterogeneity in the pricing of patent technology transfer. Therefore, the policy focus for promoting patent technology transfer in Chinese universities should be placed on enhancing patent quality, standardizing the technology transfer process, improving patent information disclosure, and strengthening government support to effectively implement policy assistance.
Recovery Pattern after Decompression of Central Lumbar Spinal Stenosis – a Prospective Observational Cohort Study
Authors: Hareni Niyaz , Ebrahimnia Soheil , Rosengren Björn E. , Karlsson Magnus K. 
Published: October 2023

Abstract
Background
Detailed preoperative information is associated with superior outcomes. We aimed to describe the recovery pattern after decompression of central lumbar spinal stenosis (CLSS).
Methods
50 patients aged 51–85 years who underwent decompression without fusion due to CLSS were followed from before to after surgery (post op day 1,7, and 14). Back and leg pain were evaluated using the Numeric Rating Scale (NRS; 0 = no pain 0, 10 = worst pain) and quality of life using the EuroQol-5D index (0 = death, 1 = best), and EQ-5D-visual analogue scale (VAS; 0 = worst, 100 = best).
Results
NRS leg pain was reduced from preoperative to first postoperative day by 5.2 (6.1,4.3) (mean (95%CI)], and NRS back pain from postoperative day 1 to 7 by 0.6 (1.2,0.03) and from day 7 to 14 by 0.7 (1.3,0.2)]. In contrast, EQ-5D index increased from preoperative to first postoperative day by 0.09 (0.06,0.13) and from day 1 to 7 by 0.05 (0.02,0.08), and EQ-5D VAS from preoperative to first postoperative day by 13.7 (9.1,18.3) and from day 1 to 7 by 6.0 (2.0,10.0). After two weeks, 51% of the patients had improved above the minimal clinically important difference (MCID) in back pain and 71% in leg pain.
Conclusion
Patients scheduled for decompression due to CLSS should be informed that improvement in leg pain and quality of life in general can be expected within one day of surgery, that quality of life improves a little further in the first postoperative week, and that back pain improves in the first 2 postoperative weeks. In most patients, decompression without fusion due to CLSS seems to achieve clinically relevant improvement within 2 weeks.
Splicing across adipocyte differentiation is highly dynamic and impacted by metabolic phenotype
Authors: Nobrega Marcelo , Farris Kathryn , Andersen Emil , Donkin Ida , Versteyhe Soetkin , Kristiansen Viggo B , Simpson Stephen , Barres Romain 
Published: October 2023

Abstract
Adipose tissue dysfunction underlies many of the metabolic complications associated with obesity. A better understanding of the gene regulation differences present in metabolically unhealthy adipose tissue can provide insights into the mechanisms underlying adipose tissue dysfunction. Here, we used RNA-seq data collected from a differentiation time course of lean, obese, and obese with type 2 diabetes (T2D) individuals to characterize the role of alterative splicing in adipocyte differentiation and function. We found that splicing was highly dynamic across adipocyte differentiation in all three cohorts, and that the dynamics of splicing were significantly impacted by metabolic phenotype. We also found that there was very little overlap between genes that were differentially spliced in adipocyte differentiation and those that were differentially expressed, positioning alternative splicing as a largely independent gene regulatory mechanism whose impact would be missed when looking at gene expression changes alone. To assess the impact of alternative splicing across adipocyte differentiation on genetic risk for metabolic diseases, we integrated the differential splicing results generated here with genome-wide association study results for body mass index and T2D, and found that variants associated with T2D were enriched in regions that were differentially spliced in early differentiation. These findings provide insight into the role of alternative splicing in adipocyte differentiation and can serve as a resource to guide future variant-to-function studies.
Synergistic associations of antenatal care visits and iron-folic acid supplementation with low birth weight: A pooled analysis of national surveys from six South Asian countries
Authors: Khanal Vishnu , MScIH Sangita Bista , Mishra Shiva Raj 
Published: October 2023

Abstract
Background
The prevalence of low birth weight (LBW) has remained high in the South Asian region with a significant impact on newborn survival. While antenatal care (ANC) and iron-folic acid supplementation independently have been considered effective interventions to improve maternal and newborn outcomes, the evidence on the combined effect of these two services with LBW is lacking. This study aimed to examine the synergistic impact of ANC and iron-folic acid supplementation on LBW in the South Asian region using pooled data from six countries.
Methods
Nationally representative surveys from Nepal, India, Bangladesh, Pakistan, Maldives, and Afghanistan were included in the study. Birth weight and the prevalence of LBW for singleton last-born children were reported using descriptive statistics. The association between LBW and ANC visits and the two-way interaction between iron-folic acid consumption and ANC were examined using multiple logistic regression.
Results
Mean birth weight in the region was 2841.8 grams with a LBW prevalence of 17.1%. Country-specific prevalence ranged from 11.4% in Nepal to 22.4% in Pakistan. Not attending ANC visits (adjusted odds ratio (AOR): 1.24; 95% confidence interval (CI): 1.16, 1.34) and not consuming iron-folic acid (AOR: 1.14; 95% CI: 1.08, 1.21) were significantly and positively associated with a higher likelihood of LBW. Furthermore, jointly, having < 4 ANC visits and < 180 days of iron-folic acid supplementation was associated with a higher likelihood (AOR: 1.29; 95% CI: 1.22, 1.36) of having LBW infants compared to those who had had ≥ 4 ANC visits and ≥ 180 days of iron-folic acid after controlling for key confounding factors.
Conclusions
The current study provides important evidence on the synergy between ANC visits and iron-folic acid supplementation during pregnancy to capitalize on the existing national maternal health programs in the South Asian region, including low-and middle-income countries for positive foetal outcomes.
RBP7 functions as a tumor suppressor in HR+ breast cancer by inhibiting the AKT/SREBP1 pathway and reducing fatty acid
Authors: Yu Yue , Xu Zhihua , Huang Xue , Zhang Guangbo , Chen Yan 
Published: October 2023

Abstract
Background
Increasing evidence proves that RBP7 plays a significant role in breast cancer (BC). The present study was aimed to investigate the role of RBP7.
Methods
Western Blotting and qRT-PCR were performed for evaluating the expression levels. CCK8, colony forming, xenograft mouse model, wound healing and transwell assays were conducted to examine cell ability of proliferation, invasion and migration.
Results
RBP7 was significantly decreased in HR + BC tissues and cells. RBP7 suppressed HR + BC cell proliferation in vitro and in vivo, and inhibited migration and invasion. RBP7 reduced fatty acid in HR + BC cells by inhibiting the AKT/SREBP1 pathway.
Conclusions
RBP7 may function as a tumor suppressor in HR + BC by inhibiting the AKT/SREBP1 pathway and reducing fatty acid.
The role of supervision and motivation during exercise on physical and mental health in older adults: A study protocol for a randomized controlled Trial (PRO-Training project)
Authors: Gómez-Redondo Paola , Valenzuela Pedro L. , Martínez-de-Quel Óscar , Sánchez-Martín Coral , Arroyo Mónica Cerezo , Moreno-Manzanaro David , Alegre Luis M. , Grau Amelia Guadalupe , Ara Ignacio , Mañas Asier 
Published: October 2023

Abstract

Background Although supervised exercise is frequently recommended for older adults, its superiority over unsupervised exercise remains uncertain. Furthermore, whether motivational techniques could help to enhance the effectiveness of the latter remains to be elucidated. The present randomized controlled trial aims to determine the role of supervision and motivational strategies on the safety, adherence, efficacy, and cost-effectiveness of different exercise programs for improving physical and mental health in older adults. Methods Participants (n = 120, aged 60–75 years) will be randomly allocated into five groups: 1-Control (CON), 2-Supervised exercise without motivational intervention (SUP), 3- Supervised exercise with motivational intervention (SUP+), 4- Unsupervised exercise without motivational intervention (UNSUP) and 5- Unsupervised exercise with motivational intervention (UNSUP+). Over 24 weeks, all exercise groups will participate in a multicomponent exercise program three times/week (performed in group classes at a center for SUP and SUP+, or home without supervision but with the help of a mobile app for UNSUP and UNSUP+), while the CON group will maintain their usual lifestyle. The motivational intervention (for SUP + and UNSUP + groups) will be based on the self-determination theory, including strategies such as phone calls, interactive workshops, motivational messages, informative infographics and videos. Primary outcomes will include safety, adherence, costs, and lower-body muscular function using a leg press machine. Secondary outcomes will include upper-body muscular function, physical and cardiorespiratory function, blood pressure and heart rate, body composition, health-related quality of life, cognitive performance, anxiety, depression, physical activity levels, sleep and sedentarism, biochemical markers, motivators and barriers to exercise. Assessments will be conducted at baseline, mid-intervention (i.e., week 13), at the end of the intervention (i.e., week 25), and 24 weeks later (i.e., week 49). Discussion The findings of this trial might provide valuable insights into the role of supervision and motivational strategies on the effectiveness of exercise programs for older adults. Additionally, the study could contribute to developing cost-effective interventions, supporting the design of future public policies for healthy aging. Trial registration: NCT05619250. Registered 16 November 2022.
Aspergillus fumigatus extracts upregulated mucin 5AC expression in human 16HBE bronchial epithelial cells through activation of the EGFR-MEK-ERK1/2 pathway
Authors: ZHANG Ling-Xuan , LI Meng , SONG Ge , SUN Hui-Min , GAO Fu-Sheng 
Published: October 2023

Abstract
Background
It has been demonstrated that Aspergillus fumigatus exposure leads to upregulation of MUC5AC expression in the airways epithelial cells. However, the signal pathway through which Aspergillus fumigatus induce MUC5AC expression is unknown. In this study the possible signal pathways of Aspergillus fumigatus extract (AFE) to regulate the expression of MUC5AC were investigated in human bronchial epithelial cells.
Methods
The 16HBE cells were divided into 4 groups: normal medium control group, AFE-treated group, AFE + selective inhibitor of protein tyrosine kinase of EGFR (AG1478) treated group, and AFE + inhibitor of MAPK kinase (MEK) (PD98059) treated group. The expression of EGFR, extracellular-signal regulated kinase 1/2 (ERK1/2), phospho-EGFR, phospho-ERK1/2 and MUC5AC were measured by immunofluorescence, immunohistochemistry, RT-PCR, and Western blot .
Results
Incubation with 16HBE cells for 24 h, AFE dose-dependently upregulated the expression of EGFR and ERK1/2; Incubation with 16HBE cells for 1 h, 16mg/L of AFE induced phosphorylation of EGFR and ERK1/2; Incubation with 16HBE cells, 10 M/L of AG1478 inhibited the phosphorylation of EGFR and ERK1/2, whereas 30 M/L of PD98059 only inhibited the phosphorylation of ERK1/2 and had no influence on the phosphorylation of EGFR. 16mg/L of AFE upregulated the expression of MUC5AC in 16HBE cells. The expression of MUC5AC induced by AFE in 16HBE cells could be inhibited after incubation with AG1478 or PD98059.
Conclusion
Activation of EGFR-MEK-ERK1/2 signal pathway is one of the mechanisms by which Aspergillus fumigatus upregulate the expression of MUC5AC in 16HBE cells.