bluuebunny/crossref_metadata_2025_split huggingface dataset:
Understanding the burden of mental and physical health disorders on families: findings from the Saudi National Mental Health Survey
Authors: Zedan Haya S , Bilal Lisa , Hyder Sanaa , Naseem Mohammad Talal , Akkad Marya , Al-Habeeb Abdulhameed , Al-Subaie Abdullah S , Altwaijri Yasmin 
Published: October 2023

ObjectiveTo assess prevalence and correlation of factors of family burden associated with mental and physical disorders in the general population of Saudi Arabia.Setting and participantsA secondary analysis of data from the Saudi National Mental Health Survey (SNMHS).Outcome measuresMental and physical health disorders of first-degree relatives and objective (time, financial) and subjective (distress, embarrassment) family burden.ResultsWe found significant caregiver burden for family members with mental health disorders. Around one-third of the sample was providing care for a family member with a health issue. Within this group, 40% had a mental health diagnosis. 73% of the study population reported experiencing some form of burden as a result of the care they are obligated to provide for their family members. We found the highest burden on male caregivers, in providing care for family members with serious memory disorders, mental retardation, schizophrenia or psychosis, followed by, alcohol and drug disorders, anxiety, depression or manic depression.ConclusionOur findings for family burden were statistically significant, indicating potential negative impact on caregiver coping ability with the demands of caring for family members with health issues. A comprehensive review of national mental health policies is required to integrate aspects of community mental health promotion, scale-up prevention, screening interventions and social support to protect against the difficulties of mental illness and reduce the burden on caregivers, the family, society, health system and the economy.
SARS-CoV-2 variants of concern in children and adolescents with COVID-19: a systematic review
Authors: Wiedenmann Margarethe , Ipekci Aziz Mert , Araujo-Chaveron Lucia , Prajapati Nirmala , Lam Yin Ting , Alam Muhammad Irfanul , L'Huillier Arnaud G , Zhelyazkov Ivan , Heron Leonie , Low Nicola , Goutaki Myrofora 
Published: October 2023

ObjectivesInfections by SARS-CoV-2 variants of concern (VOCs) might affect children and adolescents differently than earlier viral lineages. We aimed to address five questions about SARS-CoV-2 VOC infections in children and adolescents: (1) symptoms and severity, (2) risk factors for severe disease, (3) the risk of infection, (4) the risk of transmission and (5) long-term consequences following a VOC infection.DesignSystematic review.Data sourcesThe COVID-19 Open Access Project database was searched up to 1 March 2022 and PubMed was searched up to 9 May 2022.Eligibility criteriaWe included observational studies about Alpha, Beta, Gamma, Delta and Omicron VOCs among ≤18-year-olds. We included studies in English, German, French, Greek, Italian, Spanish and Turkish.Data extraction and synthesisTwo reviewers extracted and verified the data and assessed the risk of bias. We descriptively synthesised the data and assessed the risks of bias at the outcome level.ResultsWe included 53 articles. Most children with any VOC infection presented with mild disease, with more severe disease being described with the Delta or the Gamma VOC. Diabetes and obesity were reported as risk factors for severe disease during the whole pandemic period. The risk of becoming infected with a SARS-CoV-2 VOC seemed to increase with age, while in daycare settings the risk of onward transmission of VOCs was higher for younger than older children or partially vaccinated adults. Long-term symptoms following an infection with a VOC were described in <5% of children and adolescents.ConclusionOverall patterns of SARS-CoV-2 VOC infections in children and adolescents are similar to those of earlier lineages. Comparisons between different pandemic periods, countries and age groups should be improved with complete reporting of relevant contextual factors, including VOCs, vaccination status of study participants and the risk of exposure of the population to SARS-CoV-2.PROSPERO registration numberCRD42022295207.
Strategies for reducing pain at dressing change in chronic wounds: protocol for a mapping review
Authors: Kirkcaldy Andrew James , Wilson Matthew , Cooper Richard , Baxter Susan K , Campbell Fiona 
Published: October 2023

IntroductionAlthough pain experienced at dressing change has been reported as the worst aspect of living with chronic wounds, UK guidance for their management is primarily tailored to wound healing and only attends to pain as a secondary consideration. Consequently, there is little up-to-date guidance that specifically addresses how patients, carers and healthcare professionals should manage wound-related pain at dressing change. This mapping review will identify, describe and appraise the existing research evidence for strategies used to assess pain intensity and prevent or alleviate pain at dressing change in chronic wounds. In addition, it will highlight areas for future research and inform the development of up-to-date guidance for healthcare professionals.Methods and analysisWe will search MEDLINE and Epub Ahead of Print, In-Process & Other Non-Indexed Citations and Daily (via Ovid SP), Embase (via Ovid SP), Cochrane Central Register of Controlled Trials (via Wiley Cochrane Library), Cumulative Index of Nursing and Allied Health Literature (via EBSCO) and the Web of Science Citation Index Expanded and Social Sciences Citation Index (via Clarivate Analytics). Screening will be undertaken independently by two reviewers, with any disagreements resolved through discussion. Included studies will be subject to coding, using a tested data extraction tool, by two reviewers working independently. The methodological quality of the studies included will be reviewed using quality assessment instruments appropriate for each study design (Cochrane Risk of Bias tool (RoB 2); Risk of Bias in Non-randomised Studies of interventions tool; Critical Appraisal Skills Programme tool). Data will be described narratively and also presented visually in an interactive web-based evidence and gap map.Ethics and disseminationAs this mapping review does not collect original data, ethical approval is not applicable. Findings will be disseminated via a written report, an interactive online mapping tool and in peer-reviewed journals and conference presentations.PROSPERO registration numberCRD42021260130.
Classification of post COVID-19 condition symptoms: a longitudinal study in the Belgian population
Authors: Nayani Sarah , Castanares-Zapatero Diego , De Pauw Robby , Van Cauteren Dieter , Demarest Stefaan , Drieskens Sabine , Cornelissen Laura , Devleesschauwer Brecht , De Ridder Karin , Charafeddine Rana , Smith Pierre 
Published: October 2023

ObjectivesSince the onset of the COVID-19 pandemic, most research has focused on its acute pathophysiology, yet some people tend to experience persisting symptoms beyond the acute phase of infection, referred to as post COVID-19 condition (PCC). However, evidence on PCC is still scarce. This study aimed to assess the distribution, classification of symptoms and associated factors of PCC in adults.DesignLongitudinal online cohort study.SettingNational study in Belgium.ParticipantsParticipants were Belgian adults with a recent SARS-CoV-2 infection and were recruited when called up for contact tracing. A total of 3039 participants were included and completed an online questionnaire at the time of their infection and again 3 months later.Outcome measuresThe baseline questionnaire assessed the initial health status of the participants and their status during the acute phase of the infection. The follow-up questionnaire assessed their PCC status 3 months after infection. A latent class analysis (LCA) was performed to assess whether there are different classes of individuals with a similar set of self-reported PCC symptoms.ResultsHalf of the participants reported PCC 3 months after infection (47%). The most frequent symptoms were fatigue (21%), headache (11%) and memory problems (10%). The LCA highlighted three different classes of PCC symptoms with different risk factors: (1) a combination of loss of smell and taste, (2) a combination of neurological symptoms and (3) other heterogeneous symptoms.ConclusionsWith the increasing number of people who underwent COVID-19, PCC has become an important but complex public health problem due to the heterogeneity of its symptoms. The classification of symptoms performed in this study can help give insight into different aetiologies of PCC and better plan care according to the symptoms and needs of those affected.
Instruments for measuring patient health education competence among nursing personnel: protocol for a COSMIN-based systematic review
Authors: Wang Shuyi , Liu Ke , Shi Zeya , Chen Qirong , Tang Siyuan 
Published: October 2023

IntroductionHealth education, as a crucial strategic measure of disease prevention and control in the 21st century, has become an important part of healthcare. As the main deliverers of patient health education, nursing personnel’s patient health education competence (PHEC) has received much attention. Instruments for assessing the PHEC of nursing personnel have been developed internationally, but there is a lack of systematic reviews and evaluations of the psychometric properties of these instruments. To effectively select appropriate PHEC assessment instruments in specific contexts, a systematic and comprehensive review and evaluation of these measurement instruments are needed. The goal of this systematic review is to systematically evaluate the psychometric properties of existing PHEC instruments.Methods and analysisIn this study, eight databases will be searched between 1 March 2023 and 31 2023 to retrieve studies that include instrument(s) measuring the PHEC of nursing personnel. Two researchers will independently perform literature screening, data extraction and literature evaluation. In case of disagreement, a third researcher will be involved in the resolution. The measurement properties of PHEC assessment instruments will be systematically reviewed based on the consensus-based standards for the selection of health measurement instruments (COMSIN) methodology and guideline.Ethics and disseminationEthical approval is not applicable for this study. We will share the findings from the study at national and/or international conferences and in a peer-reviewed journal in the fields of health education and/or patient education.PROSPERO registration numberCRD42023393293.
Acupuncture as a therapeutic intervention for post-COVID-19 vaccination urticaria: a systematic review and meta-analysis protocol
Authors: Wang Zixia , Xiao Yao , Wang Muyao , Chen Qiqi , Lin Yueqi , Fang Xinyue , Wang Wenhui 
Published: October 2023

IntroductionThe COVID-19 pandemic persisted for over 3 years since its onset in December 2019, posing an ongoing global threat to human health. In the absence of specific antiviral medications for COVID-19, vaccination has emerged as a popular preventive measure adopted by the general public. However, an undesirable consequence of COVID-19 vaccination has been the frequent incidence of urticaria, a type of adverse skin manifestations. Despite the prevalence of this issue, there is currently a lack of clinical evidence exploring the potential utility of acupuncture as a therapeutic approach to managing urticaria arising after COVID-19 vaccination. To address this knowledge gap, this study aims to comprehensively evaluate the effectiveness and safety of acupuncture as a therapeutic intervention for treating urticaria in the general population following COVID-19 vaccination.Methods and analysisThe retrieval strategies employed in this study involve obtaining all relevant articles published from December 2019 to October 2023. These articles will be obtained from databases including PubMed, EMBASE, Cochrane Library, Web of Science, Chinese National Knowledge Infrastructure (CNKI), Chinese Biomedical Literature Database (SinoMed), VIP database and the WanFang database. Subsequently, the collected articles will undergo a thorough screening process based on predefined inclusion and exclusion criteria. Additionally, study quality will be evaluated using the Cochrane risk bias assessment tool. To conduct the meta-analysis, we will employ the Review Manager software (RevMan V.5.3). Finally, the study findings will be evaluated for their level of evidence.Ethics and disseminationAs this is a secondary review of published clinical data, this study does not involve direct contact with human subjects, and therefore, ethical approval and consent are not required. The findings of the study will be disseminated through a peer-reviewed journal, ensuring that the results undergo rigorous evaluation by experts in the field.PROSPERO registration numberCRD42022377343
Barriers to adherence to home-based pulmonary rehabilitation among patients with chronic obstructive pulmonary disease in Iran: a descriptive qualitative study
Authors: Sami Ramin , Salehi Kobra , Hashemi Marzieh , Haghighat Shila , Atashi Vajihe 
Published: October 2023

ObjectivesChronic obstructive pulmonary disease is a chronic disease with numerous complications. Therefore, its effective management depends on home-based pulmonary rehabilitation. The effectiveness of home-based pulmonary rehabilitation programmes in turn depends on patient adherence to them. The aim of this study was to explore the barriers to adherence to home-based pulmonary rehabilitation among patients with chronic obstructive pulmonary disease.DesignQualitative descriptive design.SettingThe lung care wards of Al-Zahra and Khorshid teaching hospitals and the comprehensive lung care clinic of Khorshid hospital, Isfahan, Iran.ParticipantsParticipants patients with chronic obstructive pulmonary disease (n=20), their family caregivers (n=15) and healthcare providers (n=14) recruited via purposive sampling.ResultsThe five main categories of the barriers to adherence to home-based pulmonary rehabilitation among patients with chronic obstructive pulmonary disease were patient-related barriers, caregivers’ caregiving burden, limited support for patients, healthcare providers’ limited professional competence and ineffective home-based pulmonary rehabilitation planning.ConclusionDifferent and complex factors related to patients, families and healthcare providers can affect adherence to home-based pulmonary rehabilitation among patients with chronic obstructive pulmonary disease. Healthcare authorities can use the findings of this study to develop strategies to support patients with chronic obstructive pulmonary disease and their family caregivers and thereby reduce the physical and mental complications of Chronic obstructive pulmonary disease.
Cross-sectional study investigating the association between inflammatory biomarkers and neuropathy in adolescents with type 1 diabetes
Authors: Rasmussen Vinni Faber , Hirschberg Jensen Verena , Thrysøe Mathilde , Vestergaard Esben Thyssen , Størling Joachim , Kristensen Kurt 
Published: October 2023

ObjectivesThe aims of this study were to investigate circulating levels of inflammatory markers in adolescents with type 1 diabetes with and without different types of neuropathies and evaluate the association between inflammatory biomarkers, nerve function and clinical parameters.DesignCross-sectional study.SettingHospitals and Steno Diabetes Center in Denmark.ParticipantsAdolescents with more than 5 years of diabetes duration were investigated for large fibre, small fibre and autonomic neuropathy as a part of the T1DANES study. Blood samples from the participants were analysed for inflammatory biomarkers by Meso Scale Discovery multiplexing technology.Primary and secondary outcome measuresInflammatory biomarkers and results of diagnostic nerve tests.ResultsFifty-six adolescents with type 1 diabetes and 23 healthy controls were included. The adolescents with diabetes had significantly higher interferon-gamma, tumour necrosis factor-alpha (TNF-a), interleukin (IL)-10 and soluble urokinase plasminogen activator receptor (suPAR) compared with healthy controls (p values<0.05). TNF-a was higher in the adolescents with large fibre neuropathy (LFN) (p=0.03) compared with those without LFN in the group with diabetes. A negative correlation was seen between TNF-a and conduction velocity in nervus tibialis (p=0.04), and higher TNF-a and IL-6 were associated with higher gastric motility index (TNF-a, p value=0.03; IL-6, p value=0.02). There were no significant associations between inflammatory markers and expressed symptoms, haemoglobin A1c, diabetes duration or body mass index standard derivation score (p values>0.05). The receiver operating characteristic (ROC) curves for the inflammatory markers suggested them as poor screening methods for all types of neuropathies with an area under the curve between 0.47 and 0.67.ConclusionOur results confirm increased low-grade inflammation in adolescents with type 1 diabetes. TNF-a was higher in adolescents with LFN and correlated negatively with nervus tibialis conduction velocity. The other inflammatory biomarkers fail to support differences in those with and without different types of diabetic neuropathies. However, TNF-a and IL-6 were positively correlated to gastric motility index.
Left atrial appendage closure in very elderly patients in the French National Registry
Authors: Teiger Emmanuel , Eschalier Romain , Amabile Nicolas , Rioufol Gilles , Ducrocq Gregory , Garot Philippe , Lepillier Antoine , Bille Jacques , Elbaz Meyer , Defaye Pascal , Audureau Etienne , Le Corvoisier Philippe 
Published: October 2023

ObjectiveLeft atrial appendage closure (LAAC) is recommended to decrease the stroke risk in patients with atrial fibrillation and contraindications to anticoagulation. However, age-stratified data are scarce. The aim of this study was to provide information on the safety and efficacy of LAAC, with emphasis on the oldest patients.MethodsA nationwide, prospective, multicentre, observational registry was established by 53 French cardiology centres in 2018–2021. The composite primary endpoint included ischaemic stroke, systemic embolism, and unexplained or cardiovascular death. Separate analyses were done in the groups <80 years and ≥80 years.ResultsAmong the 1053 patients included, median age was 79.7 (73.6–84.3) years; 512 patients (48.6%) were aged ≥80 years. Procedure-related serious adverse events were non-significantly more common in octogenarians (7.0% vs 4.4% in patients aged <80 years, respectively; p=0.07). Despite a higher mean CHA2DS2-VASc score in octogenarians, the rate of thromboembolic events during the study was similar in both groups (3.0 vs 3.1/100 patient-years; p=0.85). By contrast, all-cause mortality was significantly higher in octogenarians (15.3 vs 10.1/100 patient-years, p<0.015), due to a higher rate of non-cardiovascular deaths (8.2 vs 4.9/100 patient-years, p=0.034). The rate of the primary endpoint was 8.1/100 patient-years overall with no statistically significant difference between age groups (9.4 and 7.0/100 patient-years; p=0.19).ConclusionDespite a higher mean CHA2DS2-VASc score in octogenarians, the rate of thromboembolic events after LAAC in this age group was similar to that in patients aged <80 years.Trial registration numberClinicalTrials.gov Registry (NCT03434015).
Gravitational lensing in a topologically charged Eddington-inspired Born–Infeld spacetime
Authors: Soares A. R. , Vitória R. L. L. , Pereira C. F. S. 
Published: October 2023

AbstractIn the present paper, we study several aspects of gravitational lensing caused by a topologically charged Monopole/Wormhole, both in the weak field limit and in the strong field limit. We calculate the light deflection and then use it to determine the observables, with which one can investigate the existence of these objects through observational tools. We emphasize that the presence of the topological charge produces changes in the observables in relation to the case of General Relativity Ellis–Bronnikov wormhole.
Magnetic shielding simulation for particle detection
Authors: Cabo Sara R. , Gómez Sergio Luis Suárez , Bonavera Laura , Sanchez Maria Luisa , Santos Jesús Daniel , de Cos Francisco Javier 
Published: October 2023

AbstractCherenkov-type particle detectors or scintillators use as a fundamental element photomultiplier tubes, whose efficiency decreases when subjected to the Earth’s magnetic field. This work develops a geomagnetic field compensation system based on coils for large scale cylindrical detectors. The effect of different parameters such as the size of the detector, the distance between coils or the magnetic field strength on the compensation using a basic coil system composed of circular and rectangular coils is studied. The addition of coils of very specific geometry and position to the basic configuration is proposed in order to address the compensation in the areas of the detector where it is more difficult to influence, in order to minimize the loss of efficiency. With such improvement, in the considered simulated system, more than 99.5% of the photomultiplier tubes in the detector experience an efficiency loss of less than 1% due to the effect of the magnetic fields.
Low vitamin D and uric acid status in patients with benign paroxysmal positional vertigo
Authors: Ren Yuan-Yuan , Wang Yan-Jun , Li Jin-Lan , Liu Mo , Xia Fei 
Published: October 2023

Purpose Growing evidence reported that vitamin D and uric acid metabolism played roles in the occurrence of benign paroxysmal positional vertigo, an otoconia-related vestibular disorder. We aimed to investigate the serum 25-hydroxy vitamin D (25(OH)D) and uric acid in patients with benign paroxysmal positional vertigo and to determine the risk factor for benign paroxysmal positional vertigo. Methods This case-control study comprised 182 patients with benign paroxysmal positional vertigo and 182 age- and gender-matched controls. All subjects’ age, body mass index, systolic blood pressure, diastolic blood pressure, 25-hydroxyvitamin D (25(OH)D), uric acid and serum calcium measurements were analyzed. Results We found a female preponderance of benign paroxysmal positional vertigo patients, with a median of 60 (52–66) years old. The results showed low vitamin D status both in benign paroxysmal positional vertigo and controls, with no significant difference of 25(OH)D levels between benign paroxysmal positional vertigo patients and controls ( P > 0.05). Compared with the control group, patients with benign paroxysmal positional vertigo had a higher prevalence of vitamin D deficiency and a lower prevalence of vitamin D sufficiency ( P < 0.05). Uric acid was significantly lower in the benign paroxysmal positional vertigo groups ( P < 0.05). Logistic regression analysis revealed that age and uric acid were considered higher risk predictors for benign paroxysmal positional vertigo. Conclusion Our study observed low vitamin D status in patients with benign paroxysmal positional vertigo, with no significant differences of the 25(OH)D level in patients with benign paroxysmal positional vertigo and controls. Elderly, vitamin D deficiency and low uric acid levels may be risk factors for benign paroxysmal positional vertigo occurrence.