bluuebunny/crossref_metadata_2025_split huggingface dataset:
Assessing risk factors for malnutrition among women in Bangladesh and forecasting malnutrition using machine learning approaches
Authors: Turjo Estiyak Ahmed , Rahman Md. Habibur 
Published: February 2024

Abstract
Background
This paper presents an in-depth examination of malnutrition in women in Bangladesh. Malnutrition in women is a major public health issue related to different diseases and has negative repercussions for children, such as premature birth, decreased infection resistance, and an increased risk of death. Moreover, malnutrition is a severe problem in Bangladesh. Data from the Bangladesh Demographic Health Survey (BDHS) conducted in 2017-18 was used to identify risk factors for malnourished women and to create a machine learning-based strategy to detect their nutritional status.

Methods
A total of 17022 women participants are taken to conduct the research. All the participants are from different regions and different ages. A chi-square test with a five percent significance level is used to identify possible risk variables for malnutrition in women and six machine learning-based classifiers (Naïve Bayes, two types of Decision Tree, Logistic Regression, Random Forest, and Gradient Boosting Machine) were used to predict the malnutrition of women. The models are being evaluated using different parameters like accuracy, sensitivity, specificity, positive predictive value, negative predictive value, $$F_1$$

F
1

score, and area under the curve (AUC).

Results
Descriptive data showed that 45% of the population studied were malnourished women, and the chi-square test illustrated that all fourteen variables are significantly associated with malnutrition in women and among them, age and wealth index had the most influence on their nutritional status, while water source had the least impact. Random Forest had an accuracy of 60% and 60.2% for training and test data sets, respectively. CART and Gradient Boosting Machine also had close accuracy like Random Forest but based on other performance metrics such as kappa and $$F_1$$

F
1

scores Random Forest got the highest rank among others. Also, it had the highest accuracy and $$F_1$$

F
1

scores in k-fold validation along with the highest AUC (0.604).

Conclusion
The Random Forest (RF) approach is a reasonably superior machine learning-based algorithm for forecasting women’s nutritional status in Bangladesh in comparison to other ML algorithms investigated in this work. The suggested approach will aid in forecasting which women are at high susceptibility to malnutrition, hence decreasing the strain on the healthcare system.
Predictors of malnutrition among older residents in Qatari long-term care facilities: a retrospective study
Authors: AlFehaidi Al Anoud Ali H. Z. , Khan Shafi Hashmath Ulla , Abdelrahman Rana Albdeljubbar , Ahel Nesreen Talal , Shine Pavithra , De Ramos Monica Doroja , Skairjeh Nisreen Mazin , Khan Shakeel Ahmad , Al-Saadi Reem Khalid 
Published: February 2024

Abstract
Background
Malnutrition is a prevalent issue among older adults in long-term care facilities and is associated with adverse health outcomes and increased healthcare costs. Identifying the predictors of malnutrition in this population is crucial for developing effective intervention strategies. This study aimed to explore the factors contributing to malnourishment among older individuals living in long-term care facilities in Qatar.

Methods
This cross-sectional study included 75 older adults from two long-term care facilities (Rumailah Hospital and Enaya Specialized Care Center) in Qatar. Baseline characteristics, including age, sex, length of stay, mortality, weight, body mass index, co-morbidities, and laboratory parameters, were assessed. Data were analyzed using the most recent version of the SPSS software, version 29. Predictors of malnutrition and mortality were identified using logistic regression analysis.

Results
Of the 75 older individuals included in the study, 85% (64) were malnourished. The average age of the participants was 74.89 years, with a standard deviation of 10.21. Of all participants, approximately 61% (46) were males, and 39% (29) were females. Most malnourished older adults were classified as either at “moderate (29.69%)” or “severe risk (37.50%),” according to the Geriatric Nutritional Risk Index. Malnourished participants experienced a significant percentage of weight change within 3 months (14.01 ± 7.89); the only statistically significant predictor of malnutrition was the percentage of weight change within 3 months with an odds ratio (OR) of 4.8 (confidence interval [CI] 1.56–14.75) and p-value of 0.006. Statistically significant predictors of mortality were malnutrition (OR 24.84, CI 1.09–564) and age (OR 1.07, CI 1.00–1.14).

Conclusions
A significant predictor of malnutrition in older adults identified in this study was the sudden and recent change in weight, which can be employed to detect individuals at risk early and guide tailored interventions. Malnutrition is a significant predictor of mortality. Employing a multidimensional strategy to tackle malnutrition can improve outcomes for the older individuals.
Integrating positive psychology into an English as a foreign language teacher education program
Authors: Oladrostam Elnaz , Rahmati Teymour , Nushi Musa 
Published: February 2024

AbstractPositive psychology (PP) is the study of the role of positive emotions in optimizing performance. In response to a dearth of research on harnessing the potential of PP in enriching language teacher education, the present study aimed at integrating PP into an English as a foreign language teacher education program to assess its effects on the development of positivity among teachers and possible improvement in their instructional practice. To that end, first the PERMA-Profiler was administered to 25 teachers, who were about to attend a teacher training course. The results of this phase revealed the need for an intervention to raise three focal participants’ awareness of the tenets of PP since they scored below the mean on the scale. During the second phase, the three focal participants were trained in the principles of PP for six weeks. They were also asked to write reflections about the instruction they received on a weekly basis. Thematic analysis of their reflections indicated that the teachers formed positive emotions, engagement, relationship, meaning, and accomplishment, which resulted in their enhanced instructional practice. Moreover, the participants believed that the intervention helped them actively engage with the main teacher training course. The findings imply that PP has the potential to enrich teacher education programs.
Immigrant political participation is associated with more positive majority immigration attitudes across European countries and Swiss cantons
Authors: Kende Judit , Reiter Julia , Coşkan Canan , Doosje Bertjan , Green Eva G. T. 
Published: February 2024

AbstractImmigrants are increasingly participating in politics, publicizing their political concerns and contributions. How does such political participation relate to national majorities’ immigration attitudes? Previous research suggested potential improvement of majority attitudes but also demonstrated the exacerbation of perceived threat. We investigated whether greater immigrant political participation is related to more positive or negative immigration attitudes among majority members. We implemented a cross-national and a cross-cantonal multilevel study drawing on the European Social Survey, the Second European Union Minorities and Discrimination Survey and the Swiss Migration-Mobility Survey with 43,632 participants in 26 European countries in Study 1 and with 1058 participants in 19 Swiss cantons in Study 2. Overall, higher levels of immigrant political participation were related to more positive attitudes. This association between participation and attitudes was stronger among left-wing than among right-wing nationals. Finally, we found no evidence that larger immigrant groups’ participation evoke threat and exacerbate attitudes. We conclude that immigrant political participation is associated with more positive majority attitudes.
Curcumin piperidone derivatives induce caspase-dependent apoptosis and suppress miRNA-21 expression in LN-18 human glioblastoma cells
Authors: Razali Nur Syahirah Che , Lam Kok Wai , Rajab Nor Fadilah , Jamal A. Rahman A. , Kamaludin Nurul Farahana , Chan Kok Meng 
Published: February 2024

Abstract
Background
Previously, we have reported on the two curcuminoid analogues with piperidone derivatives, namely FLDP-5 and FLDP-8 have more potent anti-proliferative and anti-migration effects than curcumin. In this study, we further investigated the mode of cell death and the mechanism involved in the cell death process induced by these analogues on human glioblastoma LN-18 cells.

Results
The FLDP-5 and FLDP-8 curcuminoid analogues induced LN-18 cell death through apoptosis in a concentration-dependent manner following 24 h of treatment. These analogues induced apoptosis in LN-18 cells through significant loss of mitochondrial mass and mitochondrial membrane potential (MMP) as early as 1-hour of treatment. Interestingly, N-acetyl-l-cysteine (NAC) pretreatment did not abolish the apoptosis induced by these analogues, further confirming the cell death process is independent of ROS. However, the apoptosis induced by the analogues is caspases-dependent, whereby pan-caspase pretreatment inhibited the curcuminoid analogues-induced apoptosis. The apoptotic cell death progressed with the activation of both caspase-8 and caspase-9, which eventually led to the activation of caspase-3, as confirmed by immunoblotting. Moreover, the existing over-expression of miRNA-21 in LN-18 cells was suppressed following treatment with both analogues, which suggested the down-regulation of the miRNA-21 facilitates the cell death process.

Conclusion
The FLDP-5 and FLDP-8 curcuminoid analogues downregulate the miRNA-21 expression and induce extrinsic and intrinsic apoptotic pathways in LN-18 cells.
Anti-Leishmania major activity of Calotropis procera extract by increasing ROS production and upregulating TNF-α, IFN-γ and iNOS mRNA expression under in vitro conditions
Authors: Amani Shahla , Alinejad Soheila , Asadi Negar , Yousefi Elham , Khademvatan Shahram , Howarth Gordon Stanley 
Published: February 2024

Abstract
Background
Leishmaniasis, caused by protozoan parasites of the genus Leishmania, is a neglected tropical disease with 700,000 to 1,000,000 global new cases annually. Adverse effects associated with expense, long-term treatment and drug resistance have made conventional therapies unfavorable, encouraging the search for alternative drugs based on plant products. In this study, the effect of Calotropis procera (Asclepiadaceae) extract against viability of promastigotes and amastigotes of Leishmania major was evaluated in vitro.

Methods
The extract from the leaves of C. procera seedlings was prepared using a methanol maceration method. The colorimetric cell viability 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide (MTT) assay was used to determine the growth-inhibitory effect of the extract on promastigotes. The level of reactive oxygen species (ROS) in promastigote cultures was determined after treatment with the extract using the 2',7'-dichlorofluorescein diacetate (DCFH-DA) method and compared with untreated cultures (control). After exposure to the extract the expression levels of tumor necrosis factor-α (TNF-α), interferon gamma (IFN-γ) and inducible nitric oxide synthase (iNOS) genes were determined and compared to control in peripheral blood mononuclear cells (PBMCs) infected with L. major.

Results
Based on the MTT assay, the C. procera extract significantly reduced the proliferation of L. major promastigotes with IC50 values of 377.28 and 222.44 μg/mL for 24 and 72 h, respectively (p < 0.01). After treatment with 222.44 and 377.28 μg/mL of C. procera extract, ROS production in L. major promastigote cultures increased 1.2- to 1.65-fold and 2- to 4-fold compared to the control, respectively (p < 0.05). C. procera extract induced significant increases in gene expression of TNF-α (2.76–14.83 fold), IFN-γ (25.63–threefold) and iNOS (16.32–3.97 fold) in infected PBMCs compared to control (p < 0.01).

Conclusions
On the basis of its anti-leishmanial activity, C. procera can be considered as a promising new plant source for the potential treatment of leishmaniasis.
Assessment of lifestyle changes related to quarantine among Saudi population during the early COVID-19 pandemic: pre- and post-analysis
Authors: Abu-Elenin Mira M. , Elshora Ahmed A. , Shahin Marwa A. , El-Fatah Nesrin K. Abd 
Published: February 2024

Abstract
Background
The escalating emergence of the COVID-19 pandemic interrupted human life due to the ever-increasing morbidity, containment measures, and the associated emotional distress. This study examined the influence of COVID-19-related measures on the lifestyle behaviors of adults living in the Kingdom of Saudi Arabia (KSA).

Methods
The study recruited 638 participants through convenience sampling in Jeddah and Taif cities, Saudi Arabia. Demographic characteristics and COVID-19-related information were collected through an anonymous self-reported electronic questionnaire. Lifestyle behaviors were assessed before and during the quarantine using the Healthy Dietary Habits Index (HDHI)-A and the International Physical Activity Questionnaire (IPAQ-SF).

Results
The study revealed significant changes in the dietary pattern: a reduction in fish intake and increased consumption of French fries and candies. Vegetables and fruit intake increased significantly. Sedentary time > 6 h per day increased from 36.7% pre to 60.8% during the pandemic. Healthy dietary index score and physical activity MET-minutes/week values were respectively 3.5% and 37.9% significantly higher before compared to the full quarantine period.

Conclusion
The pandemic detrimentally influenced eating habits and physical activity levels that led to weight gain, and hence higher vulnerability to COVID-19 infection and negative outcomes. This analysis provides public health agencies with data to tailor nutrition interventions that mitigate the observed adverse lifestyle behaviors.
Cultural, nutritional and microbial perspectives of tuak, a traditional Balinese beverage
Authors: Wijaya Leonard , Sumerta I Nyoman , Napitupulu Toga Pangihotan , Kanti Atit , Keim Ary Prihardhyanto , Howell Kate , Sudiana I Made 
Published: February 2024

AbstractPalm wine (tuak) is a traditional drink recognized worldwide as the traditional drink of Africa, Southeast Asia, and Central America. The history of alcoholic beverages in Indonesia is from the prehistoric era and is recorded in Borobudur, the largest Buddha temple in Indonesia, built in the eighth century. Although Indonesian society has experienced many social and cultural changes, the tradition of tuak production for daily drinks and ceremonies is strong and widespread and has been introduced as a tourism commodity in regions of Indonesia, especially in Bali. However, there are significant challenges in improving this traditional drink's quality and economic value. In this review, we conducted a desktop study and field survey to learn how tuak is part of Indonesian fermented beverage history, especially in Bali, linked to daily life in most traditional communities and supported by local regulators for the existence of this traditional heritage in society and economy. The nutritional composition of tuak comprises monosaccharides such as glucose and fructose, disaccharides including sucrose and maltose, organic acids, and bioactive compounds encompassing saponins, phenols, terpenoids, alkaloids, and flavonoids. Additionally, tuak contains minerals, alcohols, and essential aromatic compounds. The microorganisms engaged in the fermentation process predominantly comprise ambient air microbes and plant-associated microbes, with a significant prevalence of Saccharomyces cerevisiae, Saccharomyces chevalieri, and Zymomonas mobilis. Additionally, Candida tropicalis yeast is present in the microbial consortium involved in the fermentation. This understanding will provide comprehensive information from a socio-economic perspective to preserve production, celebrate culture and to further develop the value of traditional beverages.
Development and validation of an instrument for measuring civic scientific literacy
Authors: Liu Yuemei , Wang Jian , Zhang Zhimin , Wang Jingchun , Luo Tian , Lin Shan , Li Jiaxin , Xu Sumeng 
Published: February 2024

AbstractCivic scientific literacy (CSL) is a fundamental indicator of social development and national literacy and is very important for personal well-being and national competitiveness. To be in line with the technological advancements and demands of the current era, we focused on “science engagement”, which is now considered an important approach to enhance the CSL of the general public, and developed a 4-dimensional CSL assessment framework based on the crucial elements for citizens to engage in science. The 4 dimensions are scientific knowledge (SK), scientific method (SM), problem-solving (PS), and scientific thought and spirit of science (STSS). With this framework, a CSL measurement instrument including 50 items was developed. Various validity evidence, including evidence with reliability close to or exceeding 0.8 for all four dimensions, supports the use of the instrument to provide a valuation of CSL. Age, location type (urban or rural), educational background, and occupation are all significant factors associated with CSL.
Response to prone positioning in COVID-19 patients with acute respiratory distress syndrome: a retrospective observational study
Authors: Adawy Zeinab , Iskandarani Ayman , Alharbi Abeer , Iskandarani Yara A. , Salem Gufran , Iskandarani Dalya A. , Ali Abdul Rahman H. , Salem Mohammed A. , Sobh Eman 
Published: February 2024

Abstract
Background
COVID-19 pneumonia and respiratory failure are the leading causes of death in COVID-19 patients. Prone positioning was hypothesized to improve oxygenation in ARDS patients and is being studied in COVID-19, but the current evidence is still unclear regarding survival and hospitalization. We aimed to investigate the effect of prone positioning on oxygenation in patients with COVID-19 pneumonia and ARDS and to examine the factors associated with better/worse outcomes.

Methods
A retrospective record-based cohort study included all confirmed COVID-19 patients with pneumonia and ARDS who underwent prone positioning admitted to King Fahad Hospital, Medina, Saudi Arabia, during 2020–2021.

Results
This study included 75 cases (mean age 60.3 ± 15.7 year, 50 (66.7%) males), and all fulfilled the definition of ARDS. There was a significant improvement in oxygenation (PaO2 and PaO2/FIO2) following prone positioning (53.5 ± 6.8 vs. 60.4 ± 8.2 mmHg, p < 0.001 for PaO2 supine and prone and 120.3 ± 35 vs. 138 ± 40.2, p < 0.001 for PaO2/FIO2 supine and prone respectively). There was no significant difference in age, gender, smoking, or number of comorbidities between survivors and non-survivors. Survivors had significantly higher baseline PaO2 (p 0.018) and PF ratio (p 0.001) compared to non-survivors. They had also less severe inflammation and organ damage observed as significantly lower ferritin (p 0.001), D-dimer (p 0.026), aspartate aminotransferase (p 0.02), urea (p 0.032), creatinine (p 0.001), and higher platelet counts (p 0.001). Intubation and high-moderate comorbidity risk categories were associated with non-survival (p 0.001 and p 0.014, respectively).

Conclusion
Prone positioning is useful in the improvement of oxygenation in intubated and awake patients with COVID-19 pneumonia and ARDS. Intubation and high comorbidity risk categories were associated with non-survival.
Affective Neuroscience: Jaak Panksepp's ‘rat tickling theory of emotion’
Authors: Hook John 
Published: February 2024

SUMMARYThis article reviews the seminal work of Jaak Panksepp: Affective Neuroscience: The Foundations of Human and Animal Emotions. It outlines the basis of his theory of Basic Emotional Command Systems as common to all mammals and goes on to specify some of the key fields that have grown out of his research.
Rapidly Dissolving Trans-scleral Microneedles for Intraocular Delivery of Cyclosporine A
Authors: Alrbyawi Hamad , Annaji Manjusha , Fasina Oladiran , Palakurthi Srinath , Boddu Sai H. S. , Hassan Nageeb , Tiwari Amit K. , Suryawanshi Amol , Babu R. Jayachandra 
Published: February 2024

AbstractCyclosporine A (CsA) is a cyclic peptide immunosuppressant drug that is beneficial in the treatment of various ocular diseases. However, its ocular bioavailability in the posterior eye is limited due to its poor aqueous solubility. Conventional CsA formulations such as a solution or emulsion permeate poorly across the eye due to various static and dynamic barriers of the eye. Dissolvable microneedle (MN)-based patches can be used to overcome barrier properties and, thus, enhance the ocular bioavailability of CsA in the posterior eye. CsA-loaded dissolvable MN patches were fabricated using polyvinylpyrrolidone (PVP) and characterized for MN uniformity and sharpness using SEM. Further characterization for its failure force, penetration force, and depth of penetration were analyzed using a texture analyzer. Finally, the dissolution time, ex vivo permeation, and ocular distribution of cyclosporine were determined in isolated porcine eyes. PVP MNs were sharp, uniform with good mechanical properties, and dissolved within 5 min. Ocular distribution of CsA in a whole porcine eye perfusion model showed a significant increase of CsA levels in various posterior segment ocular tissues as compared to a topically applied ophthalmic emulsion (Restasis®) (P < 0.001). Dissolving MNs of CsA were prepared, and the MN arrays can deliver CsA to the back of the eye offering potential for treating various inflammatory diseases.
Sodium-glucose Co-transporter-2 Inhibitors Causing Candida tropicalis Fungemia and Renal Abscess
Authors: Simhadri Prathap Kumar , Vaitla Pradeep , Sriperumbuduri Sriram , Chandramohan Deepak , Singh Prabhat , Murari Ujjwala 
Published: February 2024

Abstract
Sodium-glucose cotransporter-2 inhibitors (SGLT2i) are a relatively newer class of medications, approved by the U.S. Food and Drug Administration in 2013 to treat type 2 diabetes mellitus. Over the past few years, the indications for SGLT2i have been expanded to decrease the risk of kidney disease and cardiovascular disease. SGLT2i are associated with an increased risk of euglycemic diabetic ketoacidosis, urinary tract infections, and genital mycotic infections. There are a few case reports of severe invasive fungal infections due to Candida in patients using SGLT2i. We present the case of Candida tropicalis fungemia and renal abscess in a patient on an SGLT2i.