bluuebunny/crossref_metadata_2025_split huggingface dataset:
P‐Chiral Monodentate Diamidophosphites — New and Efficient Ligands for Palladium‐Catalyzed Asymmetric Allylic Substitution.
Authors: Tsarev Vasily N. , Lyubimov Sergey E. , Shiryaev Alexei A. , Zheglov Sergey V. , Bondarev Oleg G. , Davankov Vadim A. , Kabro Anzhelika A. , Moiseev Sergey K. , Kalinin Valery N. , Gavrilov Konstantin N. 
Published: August 2004

AbstractFor Abstract see ChemInform Abstract in Full Text.
Enantioselective O‐ and N‐Nitroso Aldol Synthesis of Tin Enolates. Isolation of Three BINAP—Silver Complexes and Their Role in Regio‐ and Enantioselectivity.
Authors: Momiyama Norie , Yamamoto Hisashi 
Published: August 2004

AbstractFor Abstract see ChemInform Abstract in Full Text.
Orthoamide. Part 60. N,N,N′,N′‐Tetraformylhydrazine — A Formylation Agent for Aromatic Compounds of Wide Scope.
Authors: Kantlehner Willi , Haug Erwin , Scherr Oliver , Stoyanov Edmont V. , Mezger Jochen , Ziegler Georg 
Published: August 2004

AbstractFor Abstract see ChemInform Abstract in Full Text.
Lewis Acid‐Catalyzed Reactions of Anthrone: Preference for Cycloaddition Reaction over Conjugate Addition Depending on the Functionality of α,β‐Unsaturated Carbonyl Compounds.
Authors: Baik Woonphil , Yoon Cheol Hoon , Koo Sangho , Kim Hakwon , Kim Jihan , Kim Jeongryul , Hong Soodong 
Published: August 2004

AbstractFor Abstract see ChemInform Abstract in Full Text.
Formation of 3‐Pyrrolin‐2‐ones via 5‐endo‐trig Cyclization.
Authors: Naitoh Ruri , Nakamura Yayoi , Katano Emi , Nakamura Yohoko , Okada Emi , Asaoka Morio 
Published: August 2004

AbstractFor Abstract see ChemInform Abstract in Full Text.
Asymmetric Radical Cyclization Reactions of Axially Chiral N‐Allyl‐o‐iodoanilides to Form Enantioenriched N‐Acyl Dihydroindoles.
Authors: Curran Dennis P. , Chen Christine H.‐T. , Geib Steven J. , Lapierre Andre J. B. 
Published: August 2004

AbstractFor Abstract see ChemInform Abstract in Full Text.
Studies on Synthesis and Anitbacterial Activity of Novel 4‐Substituted Phenyl‐2‐oxo‐1,3‐oxazolidine‐5‐carboxylates.
Authors: Madhusudhan G. , Reddy G. Om , Ramanatham J. , Dubey P. K. 
Published: August 2004

AbstractFor Abstract see ChemInform Abstract in Full Text.
Regioselective Synthesis of Fluoroalkyl Pyridine Derivatives from 3‐Fluoroalkyl Substituted 2‐Aza‐1,3‐butadienes.
Authors: Palacios Francisco , Alonso Concepcion , Rubiales Gloria , Villegas Maite 
Published: August 2004

AbstractFor Abstract see ChemInform Abstract in Full Text.
Enantiopure Bicyclic Piperidinones: Stereoselectivity in Lactam Enolate Alkylations.
Authors: Brewster Andrew G. , Broady Simon , Davies Catherine E. , Heightman Thomas D. , Hermitage Stephen A. , Hughes Mark , Moloney Mark G. , Woods Gordon 
Published: August 2004

AbstractFor Abstract see ChemInform Abstract in Full Text.
Synthesis of Dialkyl 1,4‐Dihydro‐2,6‐dimethylpyridine‐3,5‐dicarboxylates and Alkyl 1,4‐Dihydro‐2,6‐dimethyl‐3‐nitropyridine‐5‐carboxylates Possessing a C‐4 2,4‐Dioxo‐1,2,3,4‐tetrahydropyrimidin‐5‐yl (Uracil) Substituent to Determine Calcium Channel Modulation Structure—Activity Relationships.
Authors: Fassihi Afshin , Velazquez Carlos , Knaus Edward E. 
Published: August 2004

AbstractFor Abstract see ChemInform Abstract in Full Text.
Syntheses and NMR, MS and X‐Ray Investigations of Homoadamantane‐Fused Pyridopyrimidinones.
Authors: Gyarmati Zsuzsanna Cs. , Csomos Peter , Bernath Gabor , Valtamo Pauliina , Kivelae Henri , Argay Gyula , Kalman Alajos , Klika Karel D. , Pihlaja Kalevi 
Published: August 2004

AbstractFor Abstract see ChemInform Abstract in Full Text.
Simple, Efficient, High Yield Syntheses of Substituted and Unsubstituted 5‐Benzoylbarbituric Acids, and Their Corresponding Schiff Base Phenylhydrazones.
Authors: Jursic Branko S. , Neumann Donna M. , Bowdy Katharine L. , Stevens Edwin D. 
Published: August 2004

AbstractFor Abstract see ChemInform Abstract in Full Text.
Betulinic Acid and Its Derivatives as anti‐Angiogenic Agents.
Authors: Mukherjee Rama , Jaggi Manu , Rajendran Praveen , Siddiqui Mohammad J. A. , Srivastava Sanjay K. , Vardhan Anand , Burman Anand C. 
Published: August 2004

AbstractFor Abstract see ChemInform Abstract in Full Text.
Novel Reversed Chain Modified Oligopeptides via Sequential α‐N‐Mitsunobu Condensation of a Functionalized C‐Glycoside.
Authors: Turner John J. , Sikkema Friso D. , Erkelens Kees , van der Marel Gijs A. , Overkleeft Herman S. , van Boom Jacques H. , Overhand Mark 
Published: August 2004

AbstractFor Abstract see ChemInform Abstract in Full Text.
Unnatural Base Pairs Mediate the Site‐Specific Incorporation of an Unnatural Hydrophobic Component into RNA Transcripts
Authors: Endo Masayuki , Mitsui Tsuneo , Okuni Taeko , Kimoto Michiko , Hirao Ichiro , Yokoyama Shigeyuki 
Published: August 2004

AbstractFor Abstract see ChemInform Abstract in Full Text.
Diarylheptanoids from the Roots of Juglans mandshurica
Authors: Li Gao , Seo Chang‐Seob , Lee Seung‐Ho , Jahng Yurngdong , Chang Hyeun‐Wook , Lee Chong‐Soon , Woo Mi‐Hee , Son Jong‐Keun 
Published: August 2004

AbstractFor Abstract see ChemInform Abstract in Full Text.
Synthesis and Evaluation of Anticonvulsant and Antimicrobial Activities of 3‐Hydroxy‐6‐methyl‐2‐substituted 4H‐Pyran‐4‐one Derivatives.
Authors: Aytemir Mutlu Dilsiz , Calis Uensal , Oezalp Meral 
Published: August 2004

AbstractFor Abstract see ChemInform Abstract in Full Text.
Selective Human Enterovirus and Rhinovirus Inhibitors: An Overview of Capsid‐Binding and Protease‐Inhibiting Molecules
Authors: Shih Shin‐Ru , Chen Shu‐Jen , Hakimelahi Gholam Hossein , Liu Hsing‐Jang , Tseng Chen‐Tso , Shia Kak‐Shan 
Published: August 2004

AbstractFor Abstract see ChemInform Abstract in Full Text.
MDS/AML‐associated cytogenetic abnormalities in multiple myeloma and monoclonal gammopathy of undetermined significance: Evidence for frequent de novo occurrence and multipotent stem cell involvement of del(20q)
Authors: Nilsson Therese , Nilsson Lars , Lenhoff Stig , Rylander Lars , Åstrand‐Grundström Ingbritt , Strömbeck Bodil , Höglund Mattias , Turesson Ingemar , Westin Jan , Mitelman Felix , Jacobsen Sten E. W. , Johansson Bertil 
Published: August 2004

AbstractMultiple myeloma (MM) and monoclonal gammopathy of undetermined significance (MGUS) are characterized cytogenetically by 14q32 rearrangements, −13/13q−, and various trisomies. Occasionally, karyotypic patterns characteristic of myelodysplastic syndrome (MDS)/acute myeloid leukemia (AML) occur in MM, often signifying therapy‐related (t)‐MDS/t‐AML. Comparison of cytogenetic features in all published MMs (n = 993) and t‐MDS/t‐AML post‐MM (n = 117) revealed significant differences in complexity and ploidy levels and in most genomic changes. Thus, these features often can be used to distinguish between MM and t‐MDS/t‐AML. Rarely, myeloid‐associated aberrations are detected in MM without any signs of MDS/AML. To characterize such abnormalities in MM/MGUS, we ascertained all 122 MM and 26 MGUS/smoldering MM (SMM) cases analyzed in our department. Sixty‐six (54%) MMs and 8 (31%) MGUS/SMMs were karyotypically abnormal, of which 6 (9%) MMs and 3 (38%) MGUS/SMMs displayed myeloid abnormalities, that is, +8 (1 case) and 20q− (8 cases) as the sole anomalies, without any evidence of MDS/AML. One patient developed AML, whereas no MDS/AML occurred in the remaining 8 patients. In one MGUS with del(20q), fluorescence in situ hybridization analyses revealed its presence in CD34+CD38− (hematopoietic stem cells), CD34+CD38+ (progenitors), CD19+ (B cells), and CD15+ (myeloid cells). The present data indicate that 20q− occurs in 10% of karyotypically abnormal MM/MGUS cases and that it might arise at a multipotent progenitor/stem cell level. © 2004 Wiley‐Liss, Inc.
Involvement of fumarate hydratase in nonsyndromic uterine leiomyomas: Genetic linkage analysis and FISH studies
Authors: Gross Karen L. , Panhuysen Carolien I. M. , Kleinman Michael S. , Goldhammer Hilary , Jones Emlyn S. , Nassery Najlla , Stewart Elizabeth A. , Morton Cynthia C. 
Published: August 2004

AbstractRecently, germline mutations of the fumarate hydratase (FH) gene, in 1q42.1, have been found to be involved in syndromes associated with uterine leiomyomas (ULs). Compelling evidence also supports a genetic liability to develop nonsyndromic UL, although susceptibility genes have not been reported to date. Loss of heterozygosity (LOH) studies have found no or rare evidence of LOH of FH in nonsyndromic UL. However, the karyotypes of these tumors were not reported, and cytogenetic aberrations of 1q42–44 have been observed infrequently in UL. To determine whether FH mutations also may predispose women to developing nonsyndromic UL, we performed a genetic linkage study with DNA from 123 families containing at least one affected sister pair. In addition, to assess the frequency of FH loss specifically in UL with 1q rearrangements, we performed a fluorescence in situ hybridization (FISH) analysis of UL with 1q rearrangements. Analysis of the genotyping data revealed evidence suggestive of linkage to the FH region among study participants who were less than 40 years of age at diagnosis (Zlr 1.7 at D1S547, P = 0.04). FISH results showed that one copy of FH was absent in 9 of 11 ULs. These data indicate that loss of FH might be a significant event in the pathogenesis of a subset of nonsyndromic ULs. © 2004 Wiley‐Liss, Inc.
A new complex rearrangement involving the ETV6, LOC115548, and MN1 genes in a case of acute myeloid leukemia
Authors: Belloni Elena , Trubia Maurizio , Mancini Marco , Derme Valentina , Nanni Mauro , Lahortiga Idoya , Riccioni Roberta , Confalonieri Stefano , Lo‐Coco Francesco , Di Fiore Pier Paolo , Pelicci Pier Giuseppe 
Published: August 2004

AbstractA new complex rearrangement involving chromosome bands 5q13, 12p13, 22q11, and 3q12 was identified and characterized in a patient with acute myeloid leukemia. Fluorescence in situ hybridization showed the involvement of the ETV6 gene in 12p13. ETV6 primers were specifically designed for 3′‐ and 5′‐RACE‐PCR experiments, which led to the identification of the other two rearranged genes. The derivative chromosome 5 harbored a fusion of the ETV6 sequence with that of the LOC115548 gene. The two genes were placed in opposite orientation and did not encode a fusion protein. On the derivative chromosome 12, ETV6 was fused to the MN1 gene on chromosome 22. Also in this case, the insertion, within the MN1 sequence, of a portion of chromosome 3 prevented the formation of a fusion protein. Finally, the derivative chromosome 22 contained the 3′ portions of both LOC115548 and MN1, and no fusion transcript with coding potential could be predicted. In conclusion, all chromosome breakpoints led to the truncation of the three involved genes in the absence of predicted fusion proteins. This study lends further support to the hypothesis that gene disruption resulting in either loss of function or haploinsufficiency may be relevant in acute myeloid leukemia pathogenesis. © 2004 Wiley‐Liss, Inc.
MLL translocations with concurrent 3′ deletions: Interpretation of FISH results
Authors: Barber Kerry E. , Ford Anthony M. , Harris Rachel L. , Harrison Christine J. , Moorman Anthony V. 
Published: August 2004

AbstractRearrangements involving the MLL gene at 11q23 occur in a clinically relevant subgroup of patients with acute lymphoblastic leukemia (ALL) at all ages, and therefore their accurate identification at diagnosis is important. It has become commonplace to screen ALL patients for rearrangements of MLL using a dual‐color fluorescence in situ hybridization (FISH) assay. We report on 12 ALL patients with an unusual FISH result consisting of the following signal pattern: one 5′ green, no 3′ red, and one/two fusion signals. This configuration is consistent with a MLL translocation and simultaneous deletion of 3′ MLL—a well‐established phenomenon—which has been interpreted as a positive result. G‐banded and complementary metaphase FISH analyses confirmed an 11q23/MLL translocation in 8 of the 12 cases, whereas in one case, the identification of a del(11)(q23) was restricted to G‐banded analysis only. In three cases, an MLL rearrangement was excluded by extensive FISH analysis and/or Southern blotting. In conclusion, the loss of the 3′ MLL signal should not be assumed to be the result of a concurrent translocation and deletion event, and such aberrant FISH signal patterns should be investigated further by alternative methods for determining their MLL status. © 2004 Wiley‐Liss, Inc.
Emergence of translocation t(9;11)‐positive leukemia during treatment of childhood acute lymphoblastic leukemia
Authors: Metzler Markus , Strissel Pamela L. , Strick Reiner , Niemeyer Charlotte , Roettgers Silja , Borkhardt Arndt , Harbott Jochen , Ludwig Wolf D. , Stanulla Martin , Schrappe Martin , Reinhardt Dirk , Creutzig Ursula , Beck Joern D. , Rascher Wolfgang , Repp Reinald , Langer Thorsten 
Published: August 2004

AbstractTherapy‐related acute myeloid leukemia (t‐AML) characterized by the t(9;11)(p22;q23) translocation is one of the most frequent secondary malignancies. The timing of the initiation of translocation and of development of the malignant t(9;11) clone during chemotherapy is presently unknown. In the present study, we backtracked bone marrow samples from three children during treatment for acute lymphoblastic leukemia (ALL). Two patients developed a t(9;11)‐positive t‐AML 19 and 30 months after therapy start, whereas the third patient, diagnosed with a rare t(9;11)‐positive ALL, suffered from an ALL relapse 23 months after initial diagnosis. The genomic MLL–MLLT3 (MLL–AF9) fusion site was amplified by a multiplex, nested long‐range PCR and used as a clonal marker for quantification of the MLL–MLLT3‐positive cells during chemotherapy. The t(9;11)‐positive clone was detectable 13 and 18 months after therapy start in both t‐AML cases, which was 6–12 months before clinical diagnosis of the secondary malignancy. In the t(9;11)‐positive ALL patient, the identical leukemic clone reoccurred during maintenance therapy after a short molecular remission, 8 months before clinically overt ALL relapse. The time course and characteristics of the genomic breakpoints in the present t‐AML cases support the hypothesis of translocation formation as a result of defective breakage repair after topoisomerase II cleavage. © 2004 Wiley‐Liss, Inc.
WDR26: A novel Gβ‐like protein, suppresses MAPK signaling pathway
Authors: Zhu Ying , Wang Yuequn , Xia Chunzhi , Li Dali , Li Yongqing , Zeng Weiqi , Yuan Wuzhou , Liu Hui , Zhu Chuanbing , Wu Xiushan , Liu Mingyao 
Published: August 2004

AbstractWD40 repeat proteins play important roles in a variety of cellular functions, including cell growth, proliferation, apoptosis, and intracellular signal transduction. Mitogen‐activated protein kinases (MAPKs) are evolutionary conserved enzymes in cell signal transduction connecting cell‐surface receptors to critical regulatory targets within cells and control cell survival, adaptation, and proliferation. Previous studies revealed that G‐protein coupled receptors (GPCRs) play important roles in the signal transduction from extracellular stimuli to MAPKs and the WD40‐containing Gβ proteins as well as Gβ‐like proteins are involved in the stimulation and regulation of the MAPK signaling pathways. Here we report the identification and characterization of a novel human WD40 repeat protein, WD40 repeat protein 26 (WDR26). The cDNA of WDR26 is 3,729 bp, encoding a Gβ‐like protein of 514 amino acids in the cytoplasm. The protein is highly conserved in evolution across different species from yeast, Drosophila, mouse, to human. Northern blot analysis indicates that WDR26 is expressed in most of the examined human tissues, especially at a high level in skeletal muscle. Overexpression of WDR26 in the cell inhibits the transcriptional activities of ETS proteins, ELK‐1 and c‐fos serum response element (SRE), mediated by MEKK1. These results suggest that WDR26 may act as a negative regulator in MAPK signaling pathway and play an important role in cell signal transduction. © 2004 Wiley‐Liss, Inc.
Slow‐down of age‐dependent telomere shortening is executed in human skin keratinocytes by hormesis‐like‐effects of trace hydrogen peroxide or by anti‐oxidative effects of pro‐vitamin C in common concurrently with reduction of intracellular oxidative stress
Authors: Yokoo Seiichi , Furumoto Kayo , Hiyama Eiso , Miwa Nobuhiko 
Published: August 2004

AbstractThe cellular life‐span of cultivated human skin epidermis keratinocytes NHEK‐F was shown to be extended up to 150% of population doubling levels (PDLs) by repetitive addition with two autooxidation‐resistant derivatives of ascorbic acid (Asc), Asc‐2‐O‐phosphate (Asc2P), and Asc‐2‐O‐alpha‐glucoside (Asc2G), respectively, but to be not extended with Asc itself. In contrast, hydrogen peroxide (H2O2) as dilute as 20 μM which was non‐cytotoxic to the keratinocytes, or at 60 μM being marginally cytotoxic achieved the cellular longevity, unexpectedly, up to 160 and 120% of PDLs, respectively, being regarded as a hormesis‐like stimulatory effect. The lifespan‐extended cells that were administered with Asc2P, Asc2G, or 20 μM H2O2 were prevented from senescence‐induced symptoms such as PDL‐dependent enlargement of a cell size of 14.7 μm finally up to 17.4 μm upon Hayflick's limit‐called loss of proliferation ability as estimated with a channelizer, and retained young cell morphological aspects such as thick and compact shape and intense attachment to the culture substratum even upon advanced PDLs, whereas other non‐extended cells looked like thin or fibrous shape and large size upon lower PDLs. The PDL‐dependent shortening of telomeric DNA of 11.5 kb finally down to 9.12–8.10 kb upon Hayflick's limit was observed in common for each additive‐given cells, but was decelerated in the following order: 20 μM H2O2 > Asc2P = Asc2G > 60 μM H2O2 > Asc = no additive, being in accord with the order of cell longevity. Intracellular reactive oxygen species (ROS) was diminished by Asc2P, Asc2G or 20 μM H2O2, but not significantly by Asc or 60 μM H2O2 as estimated by fluorometry using the redox indicator dye CDCFH. There was no appreciable difference among NHEK keratinocytes that were administered with or without diverse additives in terms of telomerase activity per cell, which was 1.40 × 104–4.48 × 104 times lower for the keratinocytes than for HeLa cells which were examined as the typical tumor cells. Thus longevity of the keratinocytes was suggested to be achieved by slowdown of age‐dependent shortening of telomeric DNA rather than by telomerase; telomeres may suffer from less DNA lesions due to the continuous and thorough repression of intracellular ROS, which was realized either by pro‐vitamin C such as Asc2P or Asc2G that exerted an antioxidant ability more persistent than Asc itself or by 20 μM H2O2 which diminished intracellular ROS assumedly through a hormesis‐like effect. © 2004 Wiley‐Liss, Inc.
Component‐based integration of chemistry and optimization software
Authors: Kenny Joseph P. , Benson Steven J. , Alexeev Yuri , Sarich Jason , Janssen Curtis L. , Mcinnes Lois Curfman , Krishnan Manojkumar , Nieplocha Jarek , Jurrus Elizabeth , Fahlstrom Carl , Windus Theresa L. 
Published: August 2004

AbstractTypical scientific software designs make rigid assumptions regarding programming language and data structures, frustrating software interoperability and scientific collaboration. Component‐based software engineering is an emerging approach to managing the increasing complexity of scientific software. Component technology facilitates code interoperability and reuse. Through the adoption of methodology and tools developed by the Common Component Architecture Forum, we have developed a component architecture for molecular structure optimization. Using the NWChem and Massively Parallel Quantum Chemistry packages, we have produced chemistry components that provide capacity for energy and energy derivative evaluation. We have constructed geometry optimization applications by integrating the Toolkit for Advanced Optimization, Portable Extensible Toolkit for Scientific Computation, and Global Arrays packages, which provide optimization and linear algebra capabilities. We present a brief overview of the component development process and a description of abstract interfaces for chemical optimizations. The components conforming to these abstract interfaces allow the construction of applications using different chemistry and mathematics packages interchangeably. Initial numerical results for the component software demonstrate good performance, and highlight potential research enabled by this platform. © 2004 Wiley Periodicals, Inc. J Comput Chem 14: 1717–1725, 2004
Asymptotic behaviour of curved rods by the unfolding method
Authors: Griso Georges 
Published: August 2004

AbstractWe consider in this work general curved rods with a circular cross‐section of radius δ. Our aim is to study the asymptotic behaviour of such rods as δ→0, in the framework of the linear elasticity according to the unfolding method. It consists in giving some decompositions of the displacements of such rods, and then in passing to the limit in a fixed domain.A first decomposition concerns the elementary displacements of a curved rod which characterize its translations and rotations, and the residual displacements related to the deformation of the cross‐section. The second decomposition concerns the displacements of the middle‐line of the rod. We prove that such a displacement can be written as the sum of an inextensional displacement and of an extensional one. An extensional displacement will modify the length of the middle‐line, while an inextensional displacement will not change this length in a first approximation. We show that the H1‐norm of an inextensional displacement is of order 1, while that of an extensional displacement is in general, of order δ.A priori estimates are established and convergence results as δ→0, are given for the displacements. We give their unfolded limits, as well as the unfolded limits of the strain and stress tensors. To prove the convergence of the strain tensor, the introduction of elementary and residual displacements appears as essential. By passing to the limit as δ→0 in the linearized system of the elasticity, we obtain on the one hand, a variational problem that is satisfied by the limit extensional displacement, and on the other hand, a variational problem coupling the limit of inextensional displacements and the limit of the angle of torsion. Copyright © 2004 John Wiley & Sons, Ltd.