bluuebunny/crossref_metadata_2025_split huggingface dataset:
The Role of Social Environmental Networks in Influencing Environmental Knowledge and Environmental Awareness Towards Education for Sustainable Development in Malaysia and Japan
Authors: Salleh Rohani , Nordin Shahrina Md , Moughal Wajiha , Abbasi Haider Ali , Ching Poon Wai , Adnan Nurul Asyiqin Binti 
Published: January 2025

ABSTRACTThe study examines the efficient use of cutting‐edge technology, mainly social networks, to raise environmental concerns in educational institutions because it recognises the critical role that environmental awareness and knowledge play in averting such disasters. The educational sector is essential for helping students become conscious of and comprehend sustainable ecosystems. Utilising quantitative surveys, we identify patterns of social environmental networks towards ecological education frameworks among Malaysian 209 and Japanese 189 individuals of higher educational institutions. The study presents a conceptual approach that aims to enhance students' environmental knowledge and awareness by utilising social media strategically. The results indicate that social networks are an effective means of sharing environmental knowledge and promoting awareness. However, the influence of social media differs greatly depending on cultural factors and the quality of educational systems. This research pioneers the incorporation of social networks into the discourse on sustainable education, adding to the body of current literature. The results of this study are expected to provide valuable insights for policymakers who aim to use social media to raise students' understanding and help achieve sustainable development objectives. It provides invaluable information for policy‐makers, teaching professionals, and environmentalists who aim to utilise digital platforms for significant and positive change.
Scale Development and Validation of Corporate Digital Responsibility—A Consumer Perspective
Authors: Yang Ping , Ji Chunli , Prentice Catherine , Sthapit Erose , Peng Zhengyin 
Published: January 2025

ABSTRACTCorporate digital responsibility (CDR) is emerging as a prominent issue and has been sporadically discussed in the relevant literature. Due to the limited research on assessing digital responsibility, this study developed a scale that measures CDR from a consumer perspective. A mixed‐methods approach was employed to develop and validate the scale. First, an exploratory qualitative study was conducted to conceptualize consumer‐centric CDR and formulate the underlying constructs and measures. This was followed by a quantitative study to confirm the validity and reliability of the qualitative results. The scale development and validation process resulted in a measure consisting of six dimensions: digital transparency, digital privacy, digital quality, digital remedy, digital accessibility, and digital inclusiveness. This study contributes to corporate social responsibility research by introducing a consumer‐centric CDR scale, which provides practitioners with insights into how to execute responsible practices in the digitalized business arena, reflecting the preferences and expectations of consumers regarding digital responsibility.
Do High Minimum Wages Harm the Progression of Minimum Wage Workers? Evidence From the United Kingdom
Authors: Avram Silvia , Harkness Susan 
Published: January 2025

ABSTRACTUsing panel data from the United Kingdom between 2009 and 2019, we study how substantial increases in the real and relative value of the minimum wage impacted on the wage progression of covered workers. We find that progression out of minimum wage jobs is frequent, although most workers remain low paid. Using hazard rate models, we find a short‐lived negative effect on progression associated with the introduction of the National Living Wage in 2016. In subsequent years, we find no evidence of significant adverse effects. We find similar results when we model wage growth directly.
Rethinking Optimal Immunogens to Face SARS‐CoV‐2 Evolution Through Vaccination
Authors: Blanco Julià , Trinité Benjamin , Puig‐Barberà Joan 
Published: January 2025

ABSTRACTSARS‐CoV‐2, which originated in China in late 2019, quickly fueled the global COVID‐19 pandemic, profoundly impacting health and the economy worldwide. A series of vaccines, mostly based on the full SARS‐CoV‐2 Spike protein, were rapidly developed, showing excellent humoral and cellular responses and high efficacy against both symptomatic infection and severe disease. However, viral evolution and the waning humoral neutralizing responses strongly challenged vaccine long term effectiveness, mainly against symptomatic infection, making necessary a strategy of repeated and updated booster shots. In this repeated vaccination context, antibody repertoire diversification was evidenced, although immune imprinting after booster doses or reinfection was also demonstrated and identified as a major determinant of immunological responses to repeated antigen exposures. Considering that a small domain of the SARS‐CoV‐2 Spike protein, the receptor binding domain (RBD), is the major target of neutralizing antibodies and concentrates most viral mutations, the following text aims to provide insights into the ongoing debate over the best strategies for vaccine boosters. We address the relevance of developing new booster vaccines that target the evolving RBD, thus focusing on the relevant antigenic sites of the SARS‐CoV‐2 new variants. A combination of this strategy with immunofusing and computerized approaches could minimize immune imprinting, therefore optimizing neutralizing immune responses and booster vaccine efficacy.
Capacity management of forwarder with multiple carriers under uncertain flight travel time and stochastic shipment demand
Authors: Amaruchkul Kannapha 
Published: January 2025

AbstractConsider a freight forwarder who obtains cargo space from multiple carriers. Some capacities are reserved long term in advance through allotment contracts, while some are booked on short‐term daily basis. A unified mathematical program for both short‐ and long‐term problems under uncertainties is proposed. Demands are modeled using a probability distribution as in the stochastic program, whereas flight travel times belong to an uncertainty set as in robust optimization. In the first stage, the allotments are determined. In the second stage, the shipment demand materializes but the travel time is still unknown, the forwarder determines the daily allocation among flights, given the first‐stage allotment. The objective is to minimize the expected total cost in the two stages. We derive a closed‐form solution for a special case, propose a heuristic for a general case, and evaluate its performance via numerical experiments, whose historical records came from one of the largest Thai forwarders.
Building circular economy theories: A practical‐oriented perspective and a way forward
Authors: Mignacca Benito , Filippelli Serena , Strazzullo Serena , Tiburzi Luigi , Urbinati Andrea , Kirchherr Julian 
Published: January 2025

AbstractDespite the growing interest in circular economy (CE) and the recognition of CE as a research field, the process of building CE theories remains underdeveloped and disorganized. Relevant reasons might include a lack of a clear understanding of what a CE theory can be, the prevalence of gap‐spotting research, and a lack of a common goal for CE scholars. First, this forum article defines “CE theory” adopting a positivistic approach. Second, the article presents a more organized structure toward the development of a CE theory oriented on empirical practices. In addition, this study highlights how the development of “partial CE theories” focusing on specific CE practices, or a combination of them, should be the first step toward an integrative CE theory. Third, the paper suggests two main ways for developing partial CE theories: (i) consolidating concepts already developed into elements of a theoretical framework; (ii) framing future pieces of explicative research that contribute to partial CE theories. Last, by adopting a positivistic approach and a practical‐oriented perspective, this research provides an example of contribution to the partial theory of reuse. In particular, by leveraging the form of propositional theorizing, this article explains why reuse practices are expected to be observed in industries characterized by a high degree of product modularization, standardization, and innovation. In doing so, this forum article aims to enrich and foster theoretical contributions of future CE studies.
Arabidopsis CIRP1 E3 ligase modulates drought and oxidative stress tolerance and reactive oxygen species homeostasis by directly degrading catalases
Authors: Yang Heng , Zhang Yi , Lyu Shanwu , Mao Yaping , Yu Fangqin , Liu Sai , Fang Yujie , Deng Shulin 
Published: January 2025

ABSTRACTReactive oxygen species (ROS) plays critical roles in modulating plant growth and stress response and its homeostasis is fine tuned using multiple peroxidases. H2O2, a major kind of ROS, is removed rapidly and directly using three catalases, CAT1, CAT2, and CAT3, in Arabidopsis. Although the activity regulations of catalases have been well studied, their degradation pathway is less clear. Here, we report that CAT2 and CAT3 protein abundance was partially controlled using the 26S proteasome. To further identify candidate proteins that modulate the stability of CAT2, we performed yeast‐two‐hybrid screening and recovered several clones encoding a protein with RING and vWA domains, CIRP1 (CAT2 Interacting RING Protein 1). Drought and oxidative stress downregulated CIRP1 transcripts. CIRP1 harbored E3 ubiquitination activity and accelerated the degradation of CAT2 and CAT3 by direct interaction and ubiquitination. The cirp1 mutants exhibited stronger drought and oxidative stress tolerance, which was opposite to the cat2 and cat3 mutants. Genetic analysis revealed that CIRP1 acts upstream of CAT2 and CAT3 to negatively regulate drought and oxidative stress tolerance. The increased drought and oxidative stress tolerance of the cirp1 mutants was due to enhanced catalase (CAT) activities and alleviated ROS levels. Our data revealed that the CIRP1–CAT2/CAT3 module plays a vital role in alleviating ROS levels and balancing growth and stress responses in Arabidopsis.
Exploiting the efficient Exo:Cas12i3‐5M fusions for robust single and multiplex gene editing in rice
Authors: Wang Wenxue , Li Shaoya , Yang Jiaying , Li Jingying , Yan Lei , Zhang Chen , He Yubing , Xia Lanqin 
Published: January 2025

ABSTRACTThe development of a single and multiplex gene editing system is highly desirable for either functional genomics or pyramiding beneficial alleles in crop improvement. CRISPR/Cas12i3, which belongs to the Class II Type V‐I Cas system, has attracted extensive attention recently due to its smaller protein size and less restricted canonical “TTN” protospacer adjacent motif (PAM). However, due to its relatively lower editing efficiency, Cas12i3‐mediated multiplex gene editing has not yet been documented in plants. Here, we fused four 5′ exonucleases (Exo) including T5E, UL12, PapE, ME15 to the N terminal of an optimized Cas12i3 variant (Cas12i3‐5M), respectively, and systematically evaluated the editing activities of these Exo:Cas12i3‐5M fusions across six endogenous targets in rice stable lines. We demonstrated that the Exo:Cas12i3‐5M fusions increased the gene editing efficiencies by up to 12.46‐fold and 1.25‐fold compared with Cas12i3 and Cas12i3‐5M, respectively. Notably, the UL12:Cas12i3‐5M fusion enabled robust single gene editing with editing efficiencies of up to 90.42%–98.61% across the six tested endogenous genes. We further demonstrated that, although all the Exo:Cas12i5‐5M fusions were capable of multiplex gene editing, UL12:Cas12i3‐5M exhibited a superior performance in the simultaneous editing of three, four, five or six genes with efficiencies of 82.76%, 61.36%, 52.94%, and 51.06% in rice stable lines, respectively. Together, we evaluated different Exo:Cas12i3‐5M fusions systemically and established UL12:Cas12i3‐5M as the more robust system for single and multiplex gene editing in rice. The development of an alternative robust single and multiplex gene editing system will enrich plant genome editing toolkits and facilitate pyramiding of agronomically important traits for crop improvement.
Ionic Mechanisms Involved in β3‐Adrenoceptor‐Mediated Augmentation of GABAergic Transmission Onto Pyramidal Neurons in Prefrontal Cortex
Authors: Luo Fei , Zheng Jian , Deng Wei‐ke 
Published: January 2025

ABSTRACTActivation of the brain‐penetrant beta3‐adrenergic receptor (Adrb3) is implicated in the treatment of depressive disorders. Enhancing GABAergic inputs from interneurons onto pyramidal cells of prefrontal cortex (PFC) represents a strategy for antidepressant therapies. Here, we probed the effects of the activation of Adrb3 on GABAergic transmission onto pyramidal neurons in the PFC using in vitro electrophysiology. We found that Adrb3 agonist SR58611A increased both the frequency and the amplitude of miniature IPSCs (mIPSCs). Ca2+ influx through T‐type voltage‐gated Ca2+ channel (T‐type VGCC) contributed to SR58611A‐enhanced mIPSC frequency. We also found that SR58611A facilitated GABA release probability and the number of releasable vesicles through interaction with T‐type VGCC. SR58611A depolarized somatostatin (Sst) interneurons with no effects on the firing rate of action potential of Sst interneurons. SR58611A‐induced depolarization of Sst interneurons and enhancement of mIPSC frequency required inward rectifier K+ channel (Kir). Our results suggest that Kir and T‐type VGCC in Sst interneurons participate in SR58611A‐induced increase in GABA release in PFC.image
Exploring the Patients' Perspective on Digital Tools for Psychosocial Assessment in Dentistry
Authors: Kutschke Axel , Bechmann Bellarita , Häggman‐Henrikson Birgitta , Wänman Anders , Durham Justin , Lövgren Anna 
Published: January 2025

ABSTRACTBackgroundPsychosocial screening is a valuable part of the assessment of patients with orofacial pain, as psychosocial factors will affect prognosis and treatment outcomes. Paper‐based questionnaires are predominately used to assess the degree of psychosocial comorbidity; however, digital alternatives for screening questionnaires may be more cost‐effective and resource‐saving if patients are receptive to using them.ObjectiveTo evaluate how patients perceive digital psychosocial screening in dentistry.MethodUsing a qualitative approach, individual semi‐structured interviews were conducted with a purposive sample of adult patients with orofacial pain (n = 16) recruited from specialist dental clinics in Umeå and Gävle, Sweden. The interviews were transcribed verbatim and then analysed using Qualitative Content Analysis. Before the interviews, patients first completed the paper‐based questionnaires and then the digital version.ResultsThe analysis of patients' experiences resulted in an overarching theme: Patients appreciate a holistic approach, thus valuing psychosocial screening, and they particularly favour screening in a digital format. From this theme, two categories emerged:

Perceptions about health shape patients' expectations of dental care, and with deeper understanding of the value of psychosocial assessment, patients appreciate a holistic approach that includes psychosocial factors.
Digital screening is perceived by patients as a reliable, meaningful and environmentally sustainable method.
ConclusionsIn general, the patients appreciated a holistic approach in dentistry and understood the value of psychosocial screening as part of this. From the patients' perspective, digital psychosocial screening was both acceptable and beneficial. The findings support the introduction of digital psychosocial screening into daily dental practice.
Oral Dysaesthetic and Perceptual Disorder, a Distinct Subset of Chronic Orofacial Pain Without Burning Symptoms: A Case–Control Study
Authors: Musella Gennaro , Canfora Federica , Caponio Vito Carlo Alberto , Vardas Emmanouil , Kouri Maria , Nikitakis Nikolaos , Troiano Giuseppe , Aria Massimo , D'Aniello Luca , Lo Muzio Lorenzo , Mignogna Michele Davide , Adamo Daniela 
Published: January 2025

ABSTRACTBackgroundAccording to the ICOP 2020, burning mouth syndrome (BMS) is a chronic orofacial pain disorder characterised by an intraoral burning sensation, which represents the main diagnostic criterion. However, some patients experience other symptoms such as xerostomia, taste alterations and globus, without the burning sensation (non‐BMS).ObjectiveThis study aims to explore non‐BMS as a distinct subclinical entity by comparing the classical BMS with this new group of patients in a case–control study, addressing gaps in current diagnostic criteria.Methods83 non‐BMS patients were compared with an equal number of BMS patients matched for age and sex. Data on sociodemographic and risk factors, systemic comorbidities and drug intake, symptom patterns, psychological profiles were collected and statistically analysed.ResultsNo significant differences between BMS and non‐BMS groups were found in sociodemographic characteristics, comorbidities, drug consumption and extraoral symptoms. Both groups reported similar symptoms patterns, with discomfort intensifying in the evening. Although oral symptoms prevalence varied, with the burning sensation exclusive to BMS patients, none of these differences reached statistical significance. Psychological assessments revealed mild depression (17 [14–19] vs. 17 [14–20], p < 0.981), mild to moderate anxiety (18 [15–21] vs. 17 [15–20.5], p < 0.767) and sleep disturbance (5 [4–7] vs. 8 [5–10], p < 0.001) in both groups.ConclusionNon‐BMS patients exhibit similarities to BMS patients yet remain unclassified under current diagnostic criteria. Therefore, we have suggested the term “Oral Dysaesthetic and Perceptual Disorder (ODPD)” to define these patients (non‐BMS). This study emphasises the need to expand diagnostic criteria to better identify and manage ODPD patients.
Advance care planning intervention in chronic kidney care: A qualitative evaluation
Authors: Frandsen Christina Egmose , Dieperink Hans , Trettin Bettina , Agerskov Hanne 
Published: January 2025

AbstractBackgroundPatients with chronic kidney disease and their families request early and continuous advance care planning. Based on user involvement, an advance care planning intervention was developed to support patients, family members and healthcare professionals (HCPs) in advance care planning conversations in a nephrology outpatient setting.ObjectiveTo explore the experiences and perceptions of an advance care planning intervention among patients with chronic kidney disease, family members and healthcare professionals.DesignAn exploratory qualitative study with a phenomenological‐hermeneutic approach.ParticipantsSix patients with chronic kidney disease, four family members and four healthcare professionals.ApproachSemistructured interviews with patients and family members and a focus group interview with healthcare professionals were conducted. Data were analysed using Ricoeur's interpretation theory.FindingsPatients and their families were impacted in various ways when the patient received the diagnose of chronic kidney disease. The need for an advance care planning intervention was based on a range of individual needs. The intervention supported patients, their family members, and healthcare professionals through open dialogues and reflections about thoughts and concerns. Healthcare professionals' reflected that it might be too early to deliver an increased amount of care.ConclusionWhen the disease challenged family and everyday life, the advance care planning intervention was useable and facilitated an open dialogue and reflections. The advance care planning conversations developed awareness among the patients and family members about their values, preferences, and needs, and supported them in sharing them. There is a need for training in initiating and conducting advance care planning conversations among healthcare professionals.
Characterisation of sleep in a mouse model of CLN3 disease revealed sex‐specific sleep disturbances
Authors: Kane Kelby M. , Iradukunda Diane , McLouth Christopher J. , Guo Landys Z. , Wang Jun , Subramoniam Anjana , Huffman Dillon , Donohue Kevin D. , O'Hara Bruce F. , Sunderam Sridhar , Wang Qing Jun 
Published: January 2025

SummaryThe neuronal ceroid lipofuscinoses (NCLs) are a group of recessively inherited neurodegenerative diseases characterizsed by lysosomal storage of fluorescent materials. CLN3 disease, or juvenile Batten disease, is the most common NCL that is caused by mutations in the Ceroid Lipofuscinosis, Neuronal 3 (CLN3) gene. Sleep disturbances are among the most common symptoms associated with CLN3 disease that deteriorate the patients' life quality, yet this is understudied and has not been delineated in animal models of the disease. The current study utilised PiezoSleep, a non‐invasive, automated piezoelectric motion sensing system, to classify sleep and wakefulness in a Cln3Δex1–6/Δex1‐6 (Cln3KO) mouse model and age‐ and sex‐matched wild‐type (WT) controls. The sleep–wake classification by PiezoSleep was found to be about 90% accurate when validated against simultaneous polysomnographic recordings including electroencephalography (EEG) and electromyography (EMG) in a small cohort of WT and Cln3KO mice. Our large cohort PiezoSleep study revealed sleep abnormalities during the light period in male Cln3KO mice compared with WT male mice, and more subtle differences in Cln3KO female mice in the dark period compared with WT female mice. Our characterisation of sleep in the Cln3KO mouse model aligns with sleep abnormalities seen in CLN3 disease patients and serves as a basis to continue examining sleep disturbances commonly reported for CLN3 disease and other NCLs. As the first animal model study capturing sleep disturbances in CLN3 disease, our work will facilitate future studies into the potential mechanism behind sleep disturbances associated with the disease and the potential treatment strategies.
Event‐Day Options
Authors: Wright Jonathan H. 
Published: January 2025

ABSTRACTThis paper considers new options on Treasury futures than expire each Wednesday and Friday. I examine the variances implied by these options as of the night before expiration, and compare the variances just before FOMC days and employment report days with the variances on other Tuesdays or Thursdays, respectively. This can be used to measure the risk‐neutral interest rate uncertainty associated with FOMC announcements and employment reports. I can also compare the average physical and risk‐neutral uncertainty. Lastly, I construct options‐implied densities on the eve of FOMC and employment report days.