bluuebunny/crossref_metadata_2025_split huggingface dataset:
Complicaciones Psicológicas de la Hospitalización Infantil
Authors: Mejía Ortiz Ruth Aurelia , López Martinez Katheryn Mishelle , Panimboza Bonilla Christian Javier 
Published: November 2023

Introducción: El niño está en formación constante tanto física, fisiológica y psicológica por las vivencias que van surgiendo durante su crecimiento y es por ello que cuando debe ser sometido a procedimientos médico, diagnóstico, distintos tratamientos y quizás intervenciones quirúrgicas alcanza niveles de estrés conllevando a desarrollar alteraciones psicológicas a corto y largo plazo. Objetivo: Definir los trastornos psicológicos durante la estancia hospitalaria en niños. Metodología: Se realizó una búsqueda de la literatura publicada en inglés y español de los últimos 5 años en MEDLINE y PubMed por medio de palabras clave como: pediatric hospitalization, hospitalized children, psychological distress in children, alteraciones psicológicas en niños, alteraciones psicológicas en hospitalización, se recolectó la información incluyendo todos los artículos relacionados con población pediátrica, realizando resúmenes para su análisis y posterior elaboración del presente trabajo de investigación. Discusión: La enfermedad en la infancia puede tener repercusiones importantes en el desarrollo psicosocial y sus efectos son aún más notables cuando el niño precisa de hospitalización, debido a la separación de su entorno, de su familia, acciones que desencadena estados de ansiedad, depresión, tristeza, cambios de personalidad, falta de cooperación, miedo, alteración del sueño durante su estancia hospitalaria, e incluso posterior al alta. Conclusiones: Cuando un paciente pediátrico requiere hospitalización su tratamiento debe ser multidisciplinario con intervención de: Pediatra, Psicólogo, personal de Enfermería y los padres, quienes en conjunto deben actuar en forma sincronizada, para que el niño acepte y se adapte psicológicamente durante su hospitalización. Además, es necesario implementar otro tipo de tratamientos alternativos como la lectura, terapias lúdicas, risoterapia y terapia coadyuvante con animales como canes y peces dorados utilizados en varios países del mundo con notables resultados, ya que disminuyen el grado de ansiedad, el tiempo de hospitalización, con excelente recuperación biológica, psicológica y social
Manejo de la obesidad y diabetes mellitus tipo 2 con cirugía bariátrica. Una revisión sistemática
Authors: Hidalgo Acosta Javier Aquiles , Zamora Gagñay Liliana Elizabeth , Montufar Benítez Olga Italia , Coloma Hernández Priscila Andrea , Briones Franco Andreina Dayanara , Camacho Sig Tu Eduardo Estefano 
Published: November 2023

Introducción: La cirugía bariátrica es la modificación quirúrgica del estómago, el intestino o ambos para perder peso, la cual conduce a remisión de la DM2, en los pacientes con obesidad severa. Objetivo General: Describir las técnicas utilizadas en cirugía bariátrica para el manejo de la diabetes mellitus tipo 2 y obesidad. Objetivos específicos : 1) Comparar los resultados entre cirugía bariátrica versus cambio del estilo de vida sin cirugía en pacientes con diabetes y obesidad. 2 ) Conocer los beneficios a largo plazo de la cirugía bariátrica. Materiales y métodos: Para la presente revisión sistemática se utilizaron artículos médicos científicos publicados en los últimos 5 años, siguiendo los criterios de inclusión y exclusión establecidos, para la elaboración del presente manuscrito se utilizó como referencia las bases de datos Pubmed, IntechOpen, ScienceDirect, Mendeley, Wiley Online Library, Google Académico, con el título de búsqueda: cirugía bariátrica en la remisión de la diabetes mellitus tipo 2. Resultados: La cirugía bariátrica es efectiva en pacientes con diabetes mellitus tipo 2 con índice de masa corporal (IMC) de 30 a 35 kg/m 2, en la remisión de la diabetes mellitus mostro mejores resultados que los cambios de los hábitos de la vida y la dieta. De acuerdo a los resultados obtenidos en la aleatorización de los pacientes para cirugía bariátrica, comparada con los pacientes que tuvieron solo intervención en el estilo de vida, la cirugía bariátrica demostró un 70% de resolución de la esteatohepatitis no alcohólica.Conclusiones: La cirugía bariátrica y metabólica en el manejo de la diabetes tipo 2 con obesidad severa, tiene gran utilidad y beneficio en el grupo de pacientes que padecen esta patología, obteniéndose buenos resultados de acuerdo a la técnica quirúrgica empleada, cuya remisión es superior, comparado con el cambio en el estilo de vida, además reduce la mortalidad a largo plazo, demostrando gran utilidad en los pacientes con obesidad clase III o mórbida, y en los pacientes con obesidad clase II y clase I que padezcan de diabetes descompensada
Reporte de caso clínico: Tratamiento de Incidentaloma Suprarrenal Gigante con Cirugía Robótica Asistida en Paciente con Laparotomía Previa
Authors: Almagro Mercedes , Guadalupe Ramiro , Aulestia David Aulestia David , Remache Verónica , Vasconez Nicole , Estrada Giovanni Estrada Giovanni 
Published: November 2023

Introducción: Un incidentaloma suprarrenal es una masa en la unión bilateral de las glándulas suprarrenales descubierta de manera casual durante la investigación de otro tumor o de problemas no relacionados, (1.3). La prevalencia de estos tumores varía entre el 1 y el 8%; y es mayor en sujetos obesos, diabéticos e hipertensos [2,8]. Los mielo lipomas representan el 10-15% de los incidentalomas y según su tamaño y evolución varia el tratamiento y abordaje quirúrgico, Nuestro reporte de caso describe a un paciente que presenta un mielo lipoma suprarrenal “gigante” que fue tratado mediante adrenalectomía asistida por robot.
Objetivo: Describir un caso clínico de adrenalectomía robótica por un incidentaloma gigante de la glándula suprarrenal en un paciente con laparotomía previa
Material y métodos: Estudio descriptivo retrospectivo presentación de caso clínico.
Resultados: Se presenta el caso de un paciente de sexo masculino de 38 años con IMC 36 con antecedentes de laparotomía previa por trauma abdominal hace 10 años con hallazgo de incidentaloma gigante de la glándula suprarrenal derecha en donde se realiza adrenalectomía mediante cirugía robótica asistida sin complicaciones durante el transoperatorio y con resultado exitoso.
Conclusiones: El tratamiento estándar mencionado en varios artículos para el mielolipoma gigante es la adrenalectomía por laparotomía. Sin embargo, las mejoras tanto en la instrumentación como en la experiencia y capacitación de los cirujanos en la cirugía laparoscópica y robótica han logrado que el abordaje mínimamente invasivo se logre utilizar en casos más complejos.
No existe un consenso sobre cual técnica quirúrgica es la mejor sin embargo el abordaje mediante cirugía robótica es una estrategia segura para las masas suprarrenales gigantes y el galeno deberá estar en la capacidad para decir sobre cuál es la mejor vía de abordaje para cada paciente
Stereotactic radiosurgery in the management of non–small cell lung cancer brain metastases: a prospective study using the NeuroPoint Alliance Stereotactic Radiosurgery Registry
Authors: Michalopoulos Giorgos D. , Katsos Konstantinos , Grills Inga S. , Warnick Ronald E. , McInerney James , Attia Albert , Timmerman Robert , Chang Eric , Andrews David W. , D’Ambrosio Anthony L. , Cobb William S. , Pouratian Nader , Spalding Aaron C. , Walter Kevin , Jensen Randy L. , Bydon Mohamad , Asher Anthony L. , Sheehan Jason P. 
Published: November 2023

OBJECTIVE
The literature on non–small cell lung cancer (NSCLC) brain metastases (BMs) managed using stereotactic radiosurgery (SRS) relies mainly on single-institution studies or randomized controlled trials (RCTs). There is a literature gap on clinical and radiological outcomes of SRS for NSCLC metastases in real-world practice. The objective of this study was to benchmark mortality and progression outcomes in patients undergoing SRS for NSCLC BMs and identify risk factors for these outcomes using a national quality registry.

METHODS
The SRS Registry of the NeuroPoint Alliance was used for this study. This registry included patients from 16 enrolling sites who underwent SRS from 2017 to 2022. Data are prospectively collected without a prespecified research purpose. The main outcomes of this analysis were overall survival (OS), out-of-field recurrence, local progression, and intracranial progression. All time-to-event investigations included Kaplan-Meier analyses and multivariable Cox regressions.

RESULTS
Two hundred sixty-four patients were identified, with a mean age of 66.7 years and a female proportion of 48.5%. Most patients (84.5%) had a Karnofsky Performance Status (KPS) score of 80–100, and the mean baseline EQ-5D score was 0.539 quality-adjusted life years. A single lesion was present in 53.4% of the patients, and 29.1% of patients had 3 or more lesions. The median OS was 28.1 months, and independent predictors of mortality included no control of primary tumor (hazard ratio [HR] 2.1), KPS of 80 (HR 2.4) or lower (HR 2.4), coronary artery disease (HR 2.8), and 5 or more lesions present at the time of SRS treatment (HR 2.3). The median out-of-field progression-free survival (PFS) was 24.8 months, and the median local PFS was unreached. Intralesional hemorrhage was an independent risk factor of local progression, with an HR of 6.0. The median intracranial PFS was 14.0 months and was predicted by the number of lesions at the time of SRS (3–4 lesions, HR 2.2; 5–14 lesions, HR 2.5).

CONCLUSIONS
In this real-world prospective study, the authors used a national quality registry and found favorable OS in patients with NSCLC BMs undergoing SRS compared with results from previously published RCTs. The intracranial PFS was mainly driven by the emergence of new lesions rather than local progression. A greater number of lesions at baseline was associated with out-of-field progression, while intralesional hemorrhage at baseline was associated with local progression.
Postsurgical utility of copeptin for the prediction of postoperative arginine vasopressin deficiency
Authors: Donegan Diane , Bornhorst Joshua , Van Gompel Jamie , Atkinson John , Theobald J P. , Meyer Fredric F. , Link Michael J. , Peris-Celda Maria , Spears Grant , Erickson Dana 
Published: November 2023

OBJECTIVE
Arginine vasopressin deficiency (AVD) following neurosurgical procedures for pituitary disorders is common and can delay discharge. Copeptin, a stable surrogate marker of arginine vasopressin, may predict postoperative AVD. The authors’ aim was to assess the optimal postoperative sampling time and cut-point concentration of copeptin to predict the development of postsurgical AVD.

METHODS
Adults without preexisting AVD who were undergoing surgery for a pituitary lesion between February 2020 and April 2022 were eligible for study inclusion. Two samples were drawn from each patient postoperatively to assess the copeptin concentration using an immunofluorescent assay. Samples were denoted as "early" (within 6 hours of extubation) or "postoperative day 1" (POD1; within 10–30 hours of extubation). Patients were evaluated for the development of AVD.

RESULTS
One hundred ninety-two patients (54.2% female) with a median age of 54.5 years (IQR 39.8–67.0 years) were included in the study. The median copeptin concentration at both time points was significantly lower in those with AVD (transient or permanent; n = 22, 11.5%) than in those without (early: 4.9 vs 18.7 pmol/L, p < 0.001; POD1: 3.4 vs 4.9 pmol/L, p < 0.001) but did not differ in those who developed transient versus permanent AVD. The optimal copeptin cut point for the prediction of AVD was < 8.5 pmol/L for early samples (sensitivity 0.70, specificity 0.80, positive predictive value [PPV] 0.29, negative predictive value [NPV] 0.96) and < 4.3 pmol/L for POD1 samples (sensitivity 0.82, specificity 0.63, PPV 0.22, NPV 0.96). In early samples, a copeptin cutoff of 22.9 pmol/L increased the sensitivity for the detection of AVD to 95% with an NPV of 99%. The proportion of patients who had AVD was higher (60.0% vs 8.8%, p < 0.001) and the copeptin concentration lower (early: 4.3 vs 17.0 pmol/L, p < 0.001; POD1: 2.7 vs 4.9 pmol/L, p < 0.001) among those who had undergone surgery for a craniopharyngeal duct pathology versus a pituitary adenoma. Although copeptin was lower in patients with persistent Cushing’s disease than in those in remission, the difference did not reach statistical significance (early p = 0.11, POD1 p = 0.52). Furthermore, the copeptin concentration could not predict the development of syndrome of inappropriate secretion of antidiuretic hormone. Patients without AVD who had received stress dose steroids intraoperatively had lower median early copeptin (11.7 vs 19.1 pmol/L, p = 0.027).

CONCLUSIONS
In early postoperative copeptin samples, the optimal copeptin cut point for AVD diagnosis was < 8.5 pmol/L, and a level > 22.9 pmol/L had predicative utility in excluding AVD. Caution should be used when interpreting copeptin results, as patients administered glucocorticoids intraoperatively without AVD had lower median copeptin concentrations.
Attenuation of ventriculomegaly and iron overload after intraventricular hemorrhage by membrane attack complex inhibition
Authors: Holste Katherine G. , Ye Fenghui , Koduri Sravanthi , Garton Hugh J. L. , Maher Cormac O. , Keep Richard F. , Hua Ya , Xi Guohua 
Published: November 2023

OBJECTIVE
The pathophysiology of posthemorrhagic hydrocephalus (PHH) is not well understood, but recent data suggest blood components play a significant role. This study aimed to understand the timing of membrane attack complex (MAC) activation after intraventricular hemorrhage (IVH) and the effect of MAC inhibition on PHH development.

METHODS
This study was composed of four parts. First, 24 young adult male rats underwent stereotactic intraventricular injection of autologous blood or saline and MRI on day 1, 3, or 7 after hemorrhage. Second, 18 rats underwent intraventricular injection of saline, autologous blood with aurin tricarboxylic acid (ATA) in vehicle, or autologous blood with vehicle and underwent serial MRI studies on days 1 and 3 after hemorrhage. Third, 12 rats underwent intraventricular injections as above and MRI 2 hours after hemorrhage. Finally, 24 rats underwent the intraventricular injections as above, as well as serial MRI studies on days 1, 7, 14, and 28 after hemorrhage. The MR images were used to calculate ventricular volume and iron deposition. Open field testing was performed to assess functional outcomes. Outcomes on day 28 were reported as a ratio to the animal’s baseline values and normalized via log-transformation. Statistical analysis included the Shapiro-Wilk tests for normality and t-tests and 1-way analysis of variance for 2 and 3 groups of continuous variables, respectively.

RESULTS
MAC was found within the hematoma 1 day after hemorrhage and persisted until day 7. Administration of ATA resulted in similar intraventricular hematoma volumes compared to vehicle 2 hours after hemorrhage. At 1 and 3 days after hemorrhage, ATA administration resulted in significantly smaller ventricular volumes and less hemolysis within the hematoma than in the vehicle animals. Administration of ATA also resulted in significantly smaller ventriculomegaly and less iron deposition in the periventricular area than in the vehicle rats 28 days after hemorrhage. Functionally, ATA rats were significantly faster, traveled longer distances, and spent less time resting than vehicle rats at 28 days.

CONCLUSIONS
MAC was activated early and persisted within the hematoma until day 7 after IVH. MAC inhibition attenuated hemolysis in the clot and ventriculomegaly acutely after IVH. One month after hemorrhage, MAC inhibition attenuated ventriculomegaly and iron accumulation and improved functional outcomes.
Natural history and growth rate of intracranial aneurysms in Loeys-Dietz syndrome: implications for treatment
Authors: Huguenard Anna L. , Johnson Gabrielle W. , Osbun Joshua W. , Dacey Ralph G. , Braverman Alan C. 
Published: November 2023

OBJECTIVE
Loeys-Dietz syndrome (LDS) is a heritable aortopathy associated with craniofacial abnormalities and dilatation and dissection of the aorta and its branches, as well as increased risk for intracranial aneurysms (ICAs). Given the rarity of the disease, the authors aimed to better define the natural history and role for the treatment for ICAs in these patients.

METHODS
The medical records of 83 patients with LDS were retrospectively reviewed to obtain clinical and genetic history and vascular imaging of the aorta, aortic branches, and intracranial vessels. Serial radiology reports and cervical and intracranial vascular images were reviewed to determine presence, location, and size of ICAs.

RESULTS
In total, 55 patients (66.3%) had at least two screening intracranial vascular examinations, and 19 (22.9%) had at least 1 ICA detected. Aneurysms were typically small (mean ± SD 3.2 ± 1.8 mm). ICAs were most often located in the cavernous carotid, followed by the ophthalmic and anterior cerebral artery vessels. The rate of ICA growth was 0.43 ± 0.53 mm/year, similar to that of the general population. Three patients underwent intervention for an ICA, with 1 procedure complicated by stroke and resulting in transient hemiparesis. Several illustrative cases detail the authors’ experience with ICA growth, de novo aneurysm formation, and ICA intervention in this rare patient population.

CONCLUSIONS
ICAs in patients with LDS are common, are frequently small, and have a growth rate similar to that of unruptured ICAs in the general population. More aggressive or earlier intervention for asymptomatic ICAs identified in LDS patients compared with the general population is likely unwarranted based on the authors’ experience at their institution.
The Analysis of Decision of The Constitutional Court Number 97/Puu-Xiv/2016 Concerning Population Administration on The Rights and Position of Believers
Authors: Latua Abidin 
Published: November 2023

<em>The research is to take a closer and explicit look at the position of believers in the Constitutional Court's decision through synchronizing the existence or existence of believers in Yogyakarta. In order to ensure whether or not these concerns are true, and to what extent are the rights and positions guaranteed in the decision of the Constitutional Court, and what is the position of believers in the Constitutional Court Decision Number 97/PUUXIV/2016 concerning Population administration in terms of perspective (Maqāṣid ash-Syarī‘ah). The type of legal research used in the preparation of this research is field research, which is conducting direct observations with in-depth interviews with sources that have been determined based on the researcher's knowledge using the purposive sampling method. The approach used in this research is normative juridical (Statute Approach) and empirical or sociological juridical. The normative juridical approach is carried out by referring to the legal norms contained in the legislation, decisions and legal norms that exist in society. The results of the research show that the considerations of the judges of the Constitutional Court related to the Philosophical, Textual, and Sociological Legal Interpreters in deciding the case Number 97/PUU-XIV/2016 concerning the review of the Population Administration Law, have fulfilled the basic rights of believers and provide justice to adherents of the sect. trust, then when viewed with the study of Human Rights the Constitutional Court's </em>
LEGAL PROTECTION OF EMPLOYEES WITH A SPECIFIC TIME WORKING AGREEMENT WITHIN THE FRAMEWORK OF THE RULE OF LAW STATE IN INDONESIA
Authors: Santoso Imam Budi 
Published: November 2023

<p><em>Employment relationships are often carried out using a Certain Time Work Agreement (PKWT) or often called contract employees. This often happens in the practice of industrial relations in Indonesia which is sometimes made by employers by changing contracts every year with workers/labourers, even though the work carried out is work that is carried out permanently and continuously and should be done using an Indefinite Time Work Agreement (PKWTT) or often called permanent employees. In practice, entrepreneurs often violate the provisions of PKWT which have been stipulated in the provisions of the law. Although workers/labourers have complained to the Manpower Office about the actions of employers who violate PKWT, in fact, employers are reluctant to carry out decisions or recommendations from Supervisors or Mediators to improve the status of workers/labourers from PKWT to PKWTT. Then the change of PKWT status to PKWTT in the practice of the Industrial Relations Court can be carried out by Workers / Workers if the employer violates Article 59 paragraph (1) of the Job Creation Law. This has legal consequences on the fulfillment of workers' rights in accordance with the rules applicable to PKWTT. In order to guarantee legal protection for workers, the government must make implement regulations that regulate the types and names of jobs that must be done with the PKWT category and what work must be done with the PKWTT category. As well as imposing sanctions for entrepreneurs who violate the provisions of PKWT</em>.</p>
Exploring the Accounting Treatment of Exploration and Evaluation Activities in the Extraction Industry in South Africa and Australia
Authors: Van der Walt Christa , Dlamini Banele , Schutte Danie P 
Published: November 2023

The study examines the accounting treatment of exploration and evaluation assets in the extraction industry in South Africa and Australia. This study adopted a qualitative research approach and purposive sampling techniques. Data was collected from 60 entities in the extraction industry that are listed on the Johannesburg Stock Exchange (JSE) and the Australian Securities Exchange (ASX). The study found that South African entities classify exploration and evaluation assets as tangible or intangible assets using International Financial Reporting Standard (IFRS) 6. The study also observed that Australian entities classify exploration and evaluation assets as a separate class of assets using the Australian Accounting Standard Board (AASB) 6. South African entities depreciated or amortized exploration and evaluation assets, while Australian entities did not. The study concluded that even though there is high adoption of IFRS 6 or AASB 6, comparability is compromised in the extraction industry. The study recommended that IFRS 6 not offer a choice between IAS 16 or IAS 38 for the classification of exploration and evaluation assets to improve comparability and aid effective decision-making.
Volunteer Health Service in COVID-19 Prevention at Exit Toll Leces Probolinggo
Authors: Puspitasari Mellya , Munir Zainal 
Published: November 2023

Purpose: This abstract discusses the role of healthcare volunteers in COVID-19 prevention alongside government actions like Community Activity Restrictions (PPKM) at Exit Toll Leces Probolinggo.
Method: The study describes the stages of restriction and prevention activities, including assemblies, checkpoints, temperature checks, and antigen swab tests, as measures to enforce health protocols and policies among the public.
Practical Applications: The findings demonstrate that the public continues to adhere to health protocols and policies, such as mask-wearing, vaccination, and obtaining negative swab test results for travelers from July 12 to July 16, 2021. This underscores the importance of community engagement in combating Covid-19.
Conclusion: This research underscores the valuable role of volunteers in COVID-19 prevention, alongside government efforts to implement restrictions and health protocols. The study's insights contribute to our understanding of effective pandemic management strategies.