bluuebunny/crossref_metadata_2025_split huggingface dataset:
A Comparative First Principles Study of Two-Dimensional Transition Metal Dichalcogenides
Authors: TUNALI Aylin YILDIZ , YURDASAN Nazli BOZ , AKYUZ Gonul BILGEC 
Published: December 2023

Abstract
In recent years, studies on the two-dimensional transition metal dichalcogenides have become important since their potentials have useful properties in technological applications. In this respect, the structural, electronic and vibrational properties of the 12 transition metal dichalcogenide (TMD) MX2 (M = Mo,W,Cr,Ni; X = S,Se,Te) sheets are investigated using first-principles calculations. The calculated band structures show that all TMDs are semiconductors with a direct band gap at the K point, except NiX2 ones with indirect band gaps. We find energetic and dynamical stabilities of the MX2 sheets, while NiSe2 lattice becomes unstable with negative frequencies appearing in acoustic modes near the K point. We also discuss the role of average atomic mass and interatomic bonding in determining the Debye temperatures of dynamically stable dichalcogenide sheets.
RIPC may promotes angiogenesis of myocardium by downregulation of miR-148a
Authors: Li Muwei , Zhao Zhenzhou , Nie Ming , Guo Quan , Zhang Zhiwen 
Published: December 2023

Abstract
Angiogenesis is essential for repairing of cardiac tissue after myocardial infarction[1]. Remote ischemic preconditioning (RIPC) induced by cycles of transient limb ischemia and reperfusion is a very efficient cardioprotective strategy, which has pleiotropic effects, such as angiogenesis etc[1], [2]. Over the last decades many experimental and clinical studies have proven cardioprotective effects of RIPC, especially in the context of myocardial ischemia/reperfusion (I/R) injury[3]–[5]. However, the detailed mechanisms how RIPC works remains incomplete. Here, we report our investigation about the effects of RIPC in angiogenesis. And a possible mechanism that RIPC promotes angiogenesis by downregulation of miR-148a. In our study, RIPC downregulated miR-148a level in humans’ serum. Moreover, MicroRNA stem loop RT-PCR assays demonstrated that chronic RIPC (cRIPC) had lower expression of miR-148a than one-time RIPC. By analyzing HUVEC cells with overexpression or knockdown of miR-148a, it revealed that knockdown of miR-148a led to overexpression of ROCK1, YAP and Ang2, which also promotes angiogenesis. On the other hand, overexpression of miR-148a inhibited expression of ROCK1, YAP and Ang2. Overexpression of miR-148a also inhibited cell proliferation, migration, and tube formation of HUVEC cells. In conclusion, this study reveals that downregulation of miR-148a may play important role in RIPC by promoting angiogenesis. Downregulation of miR-148a could increase the expression level of ROCK1, YAP and Ang2. ROCK1 and YAP may be involved in the pathway that knockdown or downregulation of miR-148a may enhance angiogenesis through Ang2. The results provide novel understanding of the mechanism of RIPC towards angiogenesis and effect of miR-148a in angiogenesis.
Causal association between childhood obesity and risk of neuroblastoma: a Mendelian randomization study
Authors: Luo Xi , Luo Jie , Du Jun , Nie Meilan , Chen Youwang , Wang Wei , Gu Huajian 
Published: December 2023

Abstract

Background: Childhood obesity increased risk for cancer in adulthood，but no existing comprehensive Mendelian randomization (MR) studies have focused on how childhood obesity affects pediatric tumors. This study aimed to perform a MR analysis to assess the causal association between childhood obesity and neuroblastoma risk using publicly available genome-wide association studies (GWAS) summary statistics.
Methods: Childhood obesity data and neuroblastoma data are from the IEU open GWAS project, which were subjected to MR analyses. In this study, the inverse variance weighting (IVW) method was used as the predominant analysis method and was complemented by MR-Egger, simple mode, weighted median and weighted mode methods. The MR-PRESSO method was utilized to identify horizontal pleiotropy and potential outliers.
Results: This study indicated that childhood obesity rises the possibility of neuroblastoma, which was significant in the IVW [OR (95%CI), 1.209 (1.016–1.439), P = 0.033], MR-Egger [OR (95%CI), 2.889 (1.178–7.084), P = 0.046] and weighted-median [OR (95%CI), 1.302(1.038–1.632), P = 0.022] analyses, but nonsignificant in the simple mode [OR (95%CI), 1.331 (0.927–1.909), P = 0.152] and weighted mode [OR (95%CI), 1.357 (1.000–1.840), P = 0.078] analyses. No significant heterogeneity or potential pleiotropy was detected, and the possibility of weak IVs was also excluded.
Conclusion: This study revealed that childhood obesity increases the risk of neuroblastoma.
Critical buckling load analysis of porous orthotropic two-layered cylindrical panels based on trigonometric shear deformation theory
Authors: Turan Ferruh 
Published: December 2023

Abstract

The aim of this paper is to analyze the elastic buckling of porous orthotropic two-layered cylindrical panels based on the trigonometric shear deformation theory. In the porous two-layered cylindrical panel model, porosities are dispersed by uniform and non-uniform distribution patterns. The porosity-dependent material properties of two-layered cylindrical panel are assumed to vary along the layer’s thickness direction. First, the Virtual work principle is applied to derive governing equations. Then, the critical buckling load of the porous orthotropic two-layered cylindrical panels are obtained using the Galerkin’s solution procedure. Furthermore, the reliability of the current formulation is validated by several examples. Finally, the influence of porosity coefficients, porosity distribution patterns, geometrical parameters, and lamination sequences of the panel on the critical buckling load are investigated in detail.
Translation and Psychometric Evaluation of the Persian Version of the refugee post-migration stress scale (RPMS)
Authors: khaki Soore , Hosseinzadegan Fariba , Mousavi Seyed Qasem , barasteh salman 
Published: December 2023

Abstract
Background
Refugees usually face stressful events both in their destination country and during migration. So far no scale has been designed to reflect the post-migration stress in Persian-speaking refugees based on their current life conditions. Therefore, this study was conducted to determine the psychometric properties of the Persian version of the refugee post-migration stress scale (RPMS).
Methods
This methodological and cross-sectional study was conducted in 2022 on 355 Iranian refugees in Turkey. Inclusion criteria were being literate and willingness to participate in the study. Also, people who were unwilling to continue cooperation and incompletely filled questionnaire were excluded from the study. First, the original version of the scale was translated into Farsi using the standard Forward-Backward method. Then the validity of the scale was assessed through face validity, content validity, and construct validity using exploratory factor analysis, confirmatory factor analysis, and convergent validity using two scales of WHO-5 and HSCL-25. The reliability of the scale was evaluated by the internal consistency (Cronbach’s alpha). SPSS version 16 and LISREL version 8.8 software packages were used for data analysis.
Results
The face validity and content validity of the scale were confirmed, respectively, by refugees and experts with slight changes. In the exploratory factor analysis, 3 new dimensions named Communicational Distress, Supportive Distress, and Social Distress were extracted with a cumulative variance of 56.19%. Also, confirmatory factor analysis revealed a good fit of the model (RMSEA: 0.1, NFI: 0.91; CFI: 0.93; IFI: 0.93; GFI 0.79; standardized RMR: 0.085). The convergent validity assessed by the Pearson correlation between RPMS and Hopkins Symptom Checklist 25 and World Health Organization-Five Well-Being Index, respectively, were ((r = 0.33, P = 0.001) and (r= -0.30, P = 0.00)). The internal consistency of the scale (Cronbach’s alpha coefficient: 0.88) indicated its appropriate reliability.
Conclusion
According to the psychometric results of this scale in the Persian-speaking refugee population, it is a suitable scale to be used in measuring post-migration stress in refugees. Another advantage of this scale is its brevity and shortness, and it takes a short time to complete.
Design of Handover Strategy for Mobile Communication Network
Authors: Lv Zhiguo , Yu Jia , Qi Meng , Shao Hongxiang , Shi Nianfeng 
Published: December 2023

Abstract
In the new generation of mobile communication heterogeneous networks, the density of base station is high. Frequent handover operations may cause some base stations to receive a large number of access requests in a short period of time, resulting in network congestion and handover failures. To address this issue, a group based handover strategy is proposed in the paper. The base station obtains probability statistics on the movement patterns of vehicles and pedestrians based on road map information within its coverage area. Users are grouped according to the statistical results. The group based handover is adopted to replace independent handover. By calculating and comparing the handover probability of the current service user terminal switching to other base station, with the optimization goals of handover success rate, bandwidth utilization and network equilibrium gain, the group is updated to ensure its rationality and effectiveness. The simulation results show that this strategy can improve the handover success rate, bandwidth utilization and network equilibrium gain.
The Effects of Chromium on the High Temperature Corrosion of Ni-Cr Alloys Exposed to Calcium Sulfate
Authors: Ury Nicholas , Ravi Vilupanur 
Published: December 2023

Abstract
Calcium and sulfur rich deposits have been linked to failure of turbine components as a consequence of high temperature exposures (> 1000°C). There are only limited studies on the effects of these deposits on the degradation behavior of turbine alloys. To gain further understanding of this phenomenon, a systematic study was undertaken with model binary nickel-chromium alloys. Three alloys with different chromium contents – low, medium, and high – represented by Ni-5Cr, Ni-10Cr and Ni-18Cr, were exposed to CaSO4-deposit-induced corrosion in the 900–1100°C temperature range. At 1000 and 1100°C, the decomposition of CaSO4 led to the formation of calcium chromates and chromium sulfides. At the lower temperature, 900°C, there was only limited decomposition of CaSO4, allowing the formation of a continuous Cr2O3 scale was able to form.
Sturm-Liouville operator with an incomplete system of eigenfunctions and having a finite incompleteness defect
Authors: Kanguzhin Baltabek , Nurakhmetov Daulet , Aniyarov Almir 
Published: December 2023

Abstract

In this paper, we study one Sturm-Liouville problem with a nonlinear boundary condition that depends on a parameter. Depending on the value of the boundary parameter, eigenvalue problems can arise with complete, incomplete, and overflowing systems of eigenfunctions in the functional space L2[0, 1]. An example of a Sturm-Liouville operator with an incomplete system of eigenfunctions is given and the finite defect of incompleteness is calculated. Also it is given, the system of eigenfunctions of which has an excess equal to minus one. The interval of variation of the boundary parameter is found for which the system of eigenfunctions of the Sturm-Liouville operator is complete.
Intertumoral heterogeneity of bifocal breast cancer: a morphological and molecular study
Authors: Finsterbusch¹ Kai , Diest² Paul J. , Focke¹ Cornelia M. , Focke Cornelia M. 
Published: December 2023

Abstract
Purpose
To analyze concordance rates between individual foci of bifocal BC for histological grade, type and intrinsic subtype based on immunohistochemical (IHC) and mRNA-testing using MammaTyper.
Methods
We evaluated histological grade and type as well as intrinsic subtype based on IHC status for estrogen and progesterone receptors, HER2 and the mitotic activity index in 158 individual foci of 79 bifocal BC. A subgroup of 31 cases additionally underwent mRNA-based subtyping using the MammaTyper (MT) test. We calculated concordance rates between individual foci, as well as Cohen's Kappa (ᴋ).
Results
For 79 bifocal BC, concordance rates between individual foci for grade, histological type, and IHC-based subtype were 69.6% (ᴋ=0.53), 92.4% (ᴋ=0.81), and 74.7% (ᴋ=0.62), respectively. In the MT subgroup of 31 bifocal BC, concordance rates between individual foci for grade, histological type, IHC-based and mRNA-based intrinsic subtype were 87.1% (ᴋ=0.78), 90.3% (ᴋ=0.73), 87.1% (ᴋ=0.82), and 87.1% (ᴋ=0.7), respectively. Overall concordance between IHC- and mRNA-based subtype in the MT subgroup was 79% (ᴋ=0.7). In 6/79 cases (7.6%), testing of the smaller focus added clinically relevant information either on IHC- or mRNA-level: four cases showed high hormonal receptor expression while the expression in the larger focus was negative or low, warranting additional endocrine treatment; two cases presented with higher proliferative activity in the smaller focus, warranting additional chemotherapy.
Conclusion
In bifocal BC, intertumoral heterogeneity on the morphological, immunohistochemical and molecular level is common, with discordant intrinsic subtype in up to 25% between individual foci, with about 8% clinically relevant discordances.
Astrocyte-Mediated Neuronal Irregularities and Dynamics: The Complexity of the Tripartite Synapse
Authors: Garcia Den Whilrex , Jacquir Sabir 
Published: December 2023

Abstract

Despite significant advancements in recent decades, gaining a comprehensive understanding of brain computations remains a significant challenge in neuroscience. Using computational models is crucial for unraveling this complex phenomenon and is equally indispensable for studying neurological disorders. This endeavor has created many neuronal models that capture brain dynamics at various scales and complexities. These models range from highly detailed multi-compartmental models like the Hodgkin-Huxley model to simpler models like the leaky integrate-and-fire model. However, most existing models do not account for the potential influence of glial cells, particularly astrocytes, on neuronal physiology. This gap persists even with the emerging evidence indicating their critical role in regulating neural network activity, plasticity, and even neurological pathologies. While some literature focuses on modeling interactions between neurons and glial cells, these approaches are often sophisticated, mimicking the complexity of the physiological phenomenon. In our work, we aim to propose a simplified tripartite synapse model encompassing the presynaptic neuron, postsynaptic neuron, and astrocyte. This model is more straightforward yet still includes the primary astrocytic calcium dynamics. We defined the tripartite synapse model based on the Adaptive Exponential Integrate-and-Fire neuron model and a simplified scheme of the astrocyte model previously proposed by Postnov. Our results demonstrate the model’s ability to replicate essential synaptic transmission dynamics attributed to astrocytic calcium dynamics within the context of the tripartite synapse. Through our simulations, we propose that astrocytes can modify and shape the behavior and can introduce irregularities in the firing pattern of both presynaptic and postsynaptic neurons.
The Mediating Effects of Self-concept on The Relationship Between Parenting Styles and Young Children’s Social Problem-Solving in Turkey
Authors: Sezer Türker , Koçyiğit Sinan 
Published: December 2023

Abstract

The aim of this study was to investigate the associations between parenting styles, young children's social problem-solving skills, and the mediating role of self-concept in a sample of 200 Turkish preschoolers aged 48-72 months, with an equal distribution of male and female participants. The results supported the proposed model, demonstrating that the impact of democratic style on social problem-solving skills was partially mediated by self-concept, specifically self-esteem, as a parenting measure. These findings suggest that self-esteem is an essential individual characteristic to consider in relation to preschoolers' social relationships, in addition to the influence of democratic parenting behaviors.
Climate-related risk assessment in water safety plans: the case study of Acque Bresciane (Italy)
Authors: Biasibetti Michela , Longhi Elisa , Bozza Sonia , Zanotti Chiara , Rotiroti Marco , Fumagalli Letizia , Caschetto Mariachiara , Redaelli Agnese , Bonomi Tullia 
Published: December 2023

Abstract

Acque Bresciane is a public company that manages the integrated water cycle for more than 580,000 inhabitants in the Province of Brescia, in the north of Italy, providing drinking water, waste water treatment, and sewer systems. Drinking water systems are supplied with different types of groundwater, springs, and surface water sources (from lakes and rivers) whose availability and quality can be affected by climate change events. A multidisciplinary team, in collaboration with the University of Milano Bicocca, developed a specific Water Safety Plan (WSP) risk matrix focusing on the evaluation of climate-related hazardous events and calculation of their likelihood of occurrence, also using thematic maps. Moreover, to reduce the residual risks, in the risk matrix, possible control measures are suggested, such as the activation of an emergency plan, the use of other water sources, storage tanks, and interconnection with other water distribution networks. This work shows a simple and effective tool that can be applied by drinking water utilities to evaluate climate-related catchment risks, using a WSP risk matrix, thematic maps, and possible control measures to reduce risks in terms of water quality and availability and to respond with resilience to changes.
The Blessed Virgin Mary A Faithful Companion to God and Man. The Lucan Marian Perspective. PART TWO: The Blessed Virgin Mary as our Great Siste r
Authors: Ndegwa Kabatha Zachary 
Published: December 2023

The term a great brother is in use today in many circles which captures the aspect of a faithful friend or companion. One who stands with the side that feels in adequate in one way or the other. This phenomenon is both manifested in the sacred as well as the secular realms of human existence. The inadequacy employed here refers to a wide range of being incapacitated. In our scope we will employ the term great sister instead of the great brother to refer to the Blessed Virgin Mary as our great sister. It is beyond doubt that our Blessed Mother stands tall in so many ways as compared to the modern man. It is in this line that Mary fits well not only to be called our companion but our great sister. Although the great brother may be understood in terms of political economical or even social power Mary has noble values than these ones. In this paper we propose to follow St Luke in his Marian presentation and offer her to all Christians today as our great sister. We refer to Mary as our great sister not out of her worldly power or wealth but simply because of her faith, holiness and commitment in her calling after she gave birth to our Saviour. As our great sister she stands with each of us in company of her Son with the sole intention of uplifting our lowly nature to the nature of her Divine Son. The presence of our blessed mother in our lives will seduce us with her heroic virtues which will be beneficial in our Christian life. To achieve our stated purpose in this article we shall articulate the role of the Blessed Virgin Mary in the event of presenting the child Jesus in the temple.
We will then examine her active presence and contribution in the first community of believers gathered in Jerusalem awaiting the coming of the Holy Spirit anda conclusion will follow thereafter. However it is worth to note that we have also carried forward the pericope on Magnificat simply because it is our opinion that the theme of Mary as our great sister is well captured within this scope. Hence, the ongoing companionship will create more zealous Christians in professing their faith both in word and deed for Mary has taught us so.
ЗВ'ЯЗОК ІНСУЛІНОРЕЗИСТЕНТНОСТІ ТА АВТОНОМНОЇ НЕРВОВОЇ РЕГУЛЯЦІЇ В УМОВАХ ДОЗОВАНОЇ ГІПОКСІЇ В ПОХИЛОМУ ВІЦІ
Authors: Асанов Ервін , Шатило Валерій , Гавалко Анна , Антонюк-Щеглова Іванна , Наскалова Світлана , Диба Ірина 
Published: December 2023

Актуальність. З віком зростає захворюваність на цукровий діабет та частота виявлення інсулінорезистентності. Важлива роль в процесах порушення вуглеводного обміну належить регуляції автономної нервової системі.
Мета дослідження. З’ясувати стан автономної нервової регуляції та її реакцію на дозовану гіпоксію у людей похилого віку із інсулінорезистентністю.
Матеріали та методи. Обстежено 55 людей похилого віку з порушеною толерантністю до глюкози та 30 людини похилого віку зі збереженою толерантністю до глюкози. Визначали стан регуляції автономної нервової системи при диханні повітрям та при 12 % дозованої гіпоксії.
Результати. Вагусна активність в умовах нормоксії у людей похилого віку із порушеною та збереженою толерантністю до глюкози достовірно не розрізнялась. Проте у людей із порушеною толерантністю до глюкози спостерігалась більш значна активність симпатичних впливів. Встановлена наявність статистично значимого прямого кореляційного зв’язку між показниками вуглеводного обміну та станом симпатичного відділу АНС у людей похилого віку із порушенням толерантністю до глюкози.
У відповідь на дозовану гіпоксію у людей похилого віку як із порушеною, так і збереженою толерантністю до глюкози спостерігається зниження потужності всіх спектральних компонент варіабельності ритму серця. При цьому нерівномірність зниження різних спектральних компонент варіабельності ритму серця призводило до відносного превалювання симпатичної активності. Проте за умов гіпоксії у людей похилого віку із порушенням толерантності до глюкози відбувалась більш значна відносна активація симпатичної ланки автономної нервової системи.
Висновки. При порушенні толерантності до глюкози у людей похилого віку розвивається більш значна активність симпатичного відділу автономної нервової системи. Встановлено причинно-наслідковий зв'язок між підвищенням симпатичної активності та інсулінорезистентністю у людей похилого віку із порушеною толерантністю до глюкози. При розвитку порушення толерантності до глюкози у людей похилого віку за умов дозованої гіпоксії спостерігається більш значна відносна активація симпатичної відділу автономної нервової системи.