bluuebunny/crossref_metadata_2025_split huggingface dataset:
Cyclosporine successful treated Steroid-resistant checkpoint inhibitor-related pneumonitis: A case report
Authors: Deng Jiaxi , Guan Wenhui , Hu Minjuan , Deng Haiyi , Mo Wenwei , Li Ru , Sun Ni , Zhou Chengzhi , Lin Xinqing 
Published: October 2023

Abstract

Background
Immune checkpoint inhibitor-related pneumonitis (CIP) stands out as a particularly severe adverse event caused by cancer immunotherapy, with a substantial real-world incidence ranging from 13–19%. While systemic corticosteroids represent the standard treatment for CIP, therapeutic options become limited in cases where patients do not respond to steroid therapy. Such patients are classified as having steroid-resistant CIP, often associated with a poor prognosis. This case study provides insight into the symptoms, diagnostic process, and treatment approach for steroid-resistant CIP. Notably, successful management is demonstrated through the utilization of cyclosporine, highlighting its potential mechanisms of action in effectively treating steroid-resistant CIP.
Case description:
Here, we present the case of a 53-year-old male patient diagnosed with stage IVA non-small cell lung cancer(NSCLC), who experienced elevated fever, cough, and difficulty in breathing subsequent to immunotherapy treatment. Based on his medical history, clinical presentation, and imaging results, the patient was confirmed to have CIP. The patient's condition demonstrated improvement upon administration of corticosteroids; however, during the subsequent tapering of corticosteroid treatment, a resurgence of CIP occurred, eventually leading to a state of respiratory failure. Consequently, we arrived at the diagnosis of steroid-resistant CIP, prompting the implementation of a combination therapy involving cyclosporine in conjunction with corticosteroids to establish stable disease control. As the corticosteroid dosage was systematically reduced, the patient continued to exhibit a favorable response with no observable recurrence.
Conclusions
This marks the inaugural instance of effectively managing steroid-resistant CIP through the synergistic employment of cyclosporine and corticosteroids. Presently, cases of steroid-resistant CIP remain infrequent, necessitating vigilant and meticulous monitoring within clinical settings. Notably, there exists no distinct guideline specifying a singular agent for rescuing patients insensitive to corticosteroid therapy. Thus, cyclosporine emerges as a promising and efficacious treatment alternative for individuals unresponsive to corticosteroid intervention in the context of CIP.
Silicon Applications on Yield Attributes of Wheat (Triticum aestivum L.) and Biology of Wheat-Aphid (Schizaphis graminum)
Authors: Rahman Abdur , Hussain Fida , Majeed Shahid , Nazeer Muhammad Usama , Sharif Rao , Asif Muhammad , Sattar Waqar 
Published: October 2023

Abstract
Schizaphis graminum is considered an economically important sucking insect pest of wheat. It causes direct losses to leave at the vegetative stage and indirect losses by acting as a carrier of viruses and fungi. The current study was designed to determine the yield attributes of wheat and the biology of wheat-aphid induced by silicon in the field area of the Department of Entomology, Bahauddin Zakaria University Sub Campus Layyah during the 2020–2021 cropping seasons. The Randomize Complete Block Design was adopted with six treatments (0 ml, 30 ml, 50 ml, 70 ml, 80 ml, and 100 ml) with three replications. The high plant height (80.76 cm) and spike length (16.5 cm) were recorded on the application of 100ml silicon. The maximum spike weight (0.87g) was measured on the application of 100ml Si as compared to the control treatment. The results showed that 100ml silicon application significantly affects the mortality rate of first nymphal stage of aphids. At 3rd nymphal stage, the maximum mortality rate (80%) was observed as compared to control treatment (0%). The high concentration of silicon (100 ml) application had a good impact on adult longevity period and reduced it up to (21%) as compared to the control (27%). Silicon application with 100 ml concentration on wheat plants significantly reduced nymph survival (65%) and reproductive period (17 days). It concluded that 100 ml foliar application of silicon significantly impacted wheat yield attributes and the biology of wheat-aphid (S. graminum).
Effect of play on children’s mental status and relationship with caregivers during hospitalization: findings from Pakistan
Authors: Bharuchi Vardah Noor Ahmed , Rasheed Muneera Abdul 
Published: October 2023

Abstract
Background: The nurturing care framework (NCF)encompasses responsive caregiving, health, nutrition, safety and security by parents and other caregivers. It improves health, development and wellbeing of children. A hospital environment can be detrimental to the developmental and emotional needs of children hence NCF can be applied to hospitalized children.
Purpose: The aim of this study is to determine if (i) play stimulation intervention mediated by non-specialist providers (caregivers) improves the mental status of children who are hospitalized and (ii) to examine if there is a difference between parent-mediated and therapist-mediated sessions on the child’s mental status pre and post intervention.
Method: A one-group pretest-posttest research was carried out using purposive sampling in a Children’s Hospital in Karachi, Pakistan from November 2017 to December 2019. In all 351 children aged 3 months to 6 years were offered play stimulation and were observed using the Mental Status Examination Scale. Descriptive analysis and paired samples T test were used.
Results: Significant difference was observed when non-specialist providers (caregivers) provided intervention (t (44)=7.30, p=0.000). Significant difference was observed when intervention was offered by father on MSE before and after the intervention (t(77)=8.54, p=0.000) and when intervention was given by mother (t(360)=20.57, p=0.000). Difference in acute care was also observed when intervention was given by trainee therapists (t(28)=8.74, p=0.000).
Conclusion: It was concluded that play stimulation not only affects the behaviour of children but also varies when delivered by caregivers and trainees. Hence, interventions that involve parents can be helpful.
Jointly local statistics and topological proximity consideration in spectral clustering
Authors: Jamshidi Mina 
Published: October 2023

Abstract
Efficient deals of mathematical techniques have been devoted to cluster data with complicated manifold structures. Although local geometrical properties of data are considered in these techniques, some essential local statistics behaviours are ignored. In this paper, a method is proposed in which local topological and local statistics structures are jointly considered. More precisely, local correlations, local distributions and high-order proximity of data points are simultaneously considered to construct more efficient affinity matrix. Local correlations and high-order proximity are considered to modify the connectivity of the graph representation of data, and local distributions are utilized to obtain a free parameter similarity function between data points. After obtaining the new similarity matrix, spectral clustering is employed to evaluate the efficiency of it. The experimental results on various benchmark data sets demonstrate that the new method can significantly improve the clustering performance compared with state-of-the-art techniques.
Dynamic Visual SLAM Algorithm based on Lightweight YOLOv5s
Authors: Gong Xieping , Yin Yang , Wang Zheng , Li Houpu 
Published: October 2023

Abstract
Mobile robots localize themselves in unknown environments through simultaneous localization and mapping. However, most visual SLAM systems are built under the assumption that the real-world scenes are static, which limits their robustness and camera localization accuracy due to the presence of dynamic objects. To address this issue, we proposes a novel visual SLAM system that adopts the lightweight MobileNetV3 network as the backbone of the YOLOv5s object detection algorithm. Model pruning and knowledge distillation techniques are employed to reduce the model parameters by 59.01% while maintaining a minimal decrease of only 2.4% in algorithm accuracy.By integrating the improved object detection network, the LK optical flow method, and the ORB-SLAM3 system, our SLAM system effectively filters out dynamic feature points while extracting ORB feature points. Experimental evaluations on the TUM dataset reveal that proposed algorithm outperforms the ORB-SLAM3 system, achieving a 57.81% improvement in pose estimation accuracy in dynamic environments. This demonstrates enhanced precision and robustness of our algorithm in dynamic scenarios.
Semi-empirical parameterization of HI/p L-shell X-ray production cross section ratios in Bi for Heavy Ion PIXE
Authors: Masekane Masedi Carington , Msimanga Mandla , Radović Ivančica Bogdanović , Madhuku Morgan , Moloi Sabata Jonas 
Published: October 2023

Abstract
Quantitative analysis of materials from Heavy Ion PIXE spectra remains impeded by the lack of reliable X-ray production cross section (XPCS) data. Although efforts at experimental Heavy Ion induced XPCS measurements still continue, Multiple Ionisation (MI) effects, which are not fully described by theory, render simulations of Heavy Ion PIXE data unreliable for large Z 1 /Z 2 collisions, especially at low energies. This is also exacerbated by the random selection of projectile-target combinations for measured and reported experimental data available to validate theory. This study explored heavy ion induced X-ray production cross section deviations from those induced by protons at the same ion velocity. This enabled evaluations of the degree to which cross sections are enhanced through MI effects, with the aim of predicting XPCS due to heavy ion impact. The evaluation was carried out through the scaling of experimental heavy ion to theoretical proton cross section ratios (R), which were then used for the interpolation of XPCS in´missing´in´missing´ regions. Here we present measurements of heavy ion induced total L-shell XPCS in Bi, carried out to determine HI/p MI induced deviations due to C, F, Cl and Ti projectiles at an ion velocity range of 0.2-1.0 (MeV/nucleon).
Risk Assessment Protocol for Existing Bridge Infrastructure Considering Climate Change
Authors: Altamimi Shereen , Amleh Lamya , Fang Liping 
Published: October 2023

Abstract
The escalating impact of climate change on global weather patterns threatens the functionality and resilience of infrastructure systems. This paper presents a rigorous risk assessment protocol tailored to existing bridge infrastructure, integrating climate change projections, structural integrity, and socio-economic factors. The protocol's application involves five sequential steps: selecting a bridge, disassembling the structure into components, calculating utilization factors for design and projected temperatures, evaluating severity factors encompassing structural and socio-economic aspects, and ultimately determining an overall risk rating. To demonstrate the protocol's effectiveness, a case study is conducted on the Westminster Drive Underpass in London, Ontario. This study displays how the protocol systematically evaluates the vulnerability of each bridge component to projected temperatures under the Representative Concentration Pathway 6.0 model. The protocol provides a holistic risk assessment by incorporating both the structural response and socio-economic implications of failure. The results rank the bridge's risk level and highlight the urgency of intervention. The protocol emerges as a robust tool for decision-makers, practitioners, and engineers, offering a comprehensive approach to strengthen bridge infrastructure against the challenges of climate change.
Computing Sickle Erythrocyte Health Index Based on Quantitative Phase Imaging and Machine Learning
Authors: Ansong-Ansongton Yaw , Adamson Timothy 
Published: October 2023

Abstract
Sickle cell disease (SCD) is a genetic disorder characterized by abnormal hemoglobin and deformation of red blood cells (RBCs), leading to complications and reduced life expectancy. This study developed an in-vitro assessment, the Sickle Erythrocyte Health Index, using quantitative phase imaging (QPI) and machine learning to model the health of RBCs in people with SCD. The Health Index combines assessment of cell deformation, sickle-shaped classification, and membrane flexibility to evaluate erythrocyte health. Using QPI and image processing, the percentage of sickle-shaped cells and membrane flexibility were quantified. Statistically significant differences were observed between individuals with and without SCD, indicating the impact of underlying pathophysiology on erythrocyte health. Additionally, sodium metabisulfite led to an increase in sickle-shaped cells and a decrease in flexibility for the sickle cell blood samples. Based on these findings, two approaches were used to calculate the Index: one using hand-crafted features and one using learned features from deep learning models. Both indices showed significant differences between non-SCD and SCD groups and sensitivity to changes induced by sodium metabisulfite. The Sickle Erythrocyte Health Index has important clinical implications for SCD management and could be used by providers when making treatment decisions. Further research is warranted to evaluate the clinical utility and applicability of the Index in diverse patient populations.
De novo mutations in bipolar disorder implicate neurodevelopment, immunity, and synaptic signaling
Authors: Shimada Takafumi , Smith Rachel , Sung Heejong , Besancon Emily , Lopez Fabiana , Kassem Layla , Akula Nirmala , McMahon Francis 
Published: October 2023

Abstract

Bipolar disorder (BD) is a debilitating disorder affecting ~ 1% of the world’s population. Although many common and some rare alleles are associated with this complex disorder, little is known about the role of de novo variation. For the first time, this study investigates de novo mutations (DNMs) in families ascertained from genetically isolated populations. Exomes of approximately 1200 individuals consisting of 214 trios were quality controlled and analyzed using Genome Analysis Toolkit (GATK). DNMs were called using HAIL, followed by stringent sample and variant filters. Genes carrying deleterious DNMs (dDNMs) in affected participants were annotated for biological functions and associated brain co-expression modules. A total of 42 loss of function or damaging missense DNMs in 42 genes, includingNRXN1,SHANK3, andSPECC1, were detected among individuals with BD and related disorders. Additionally, five genes,XKR6,MRC2,SUGP2,DICER1,PLECshowed recurrent dDNMs, of whichXKR6andMRC2were previously reported. These genes were significantly enriched for functions related to learning, post-synaptic organization, nervous system development, and calcium ion transport. These genes also significantly overlapped with brain co-expression modules associated with neurogenesis and immunity and significantly enriched in genes expressed in excitatory neurons, endothelial cells, and microglia. These findings support a role for DNM in BD and shed light on its neurobiology. If replicated, genes with significant burdens of DNMs are good candidates for functional genomic studies.
Mark4 ablation attenuates the pathological phenotype in tauopathy model mice
Authors: Sultanakhmetov Grigorii , Limlingan Sophia Jobien M. , Fukuchi Aoi , Tsuda Keisuke , Suzuki Hirokazu , Saito Taro , Weitemier Adam Z. , Ando Kanae 
Published: October 2023

Abstract

Background
Accumulation of abnormally phosphorylated tau proteins is linked to various neurodegenerative diseases, including Alzheimer’s disease and frontotemporal dementia. However, what modifications of tau proteins cause disease phenotypes have not been fully understood. Microtubule affinity-regulating kinase 4 (MARK4) has been genetically and pathologically associated with Alzheimer’s disease and reported to enhance tau phosphorylation and toxicity in Drosophila and mouse traumatic brain-injury models but not in mammalian tauopathy models.
Methods
To investigate the role of MARK4 in tau-mediated neuropathology, we crossed P301S tauopathy model (PS19) and Mark4 knockout mice. Following standard behavior, biochemical, and histology analyses were performed to evaluate changes in PS19 pathological phenotype with and without Mark4.
Results
In this study, we demonstrated that Mark4 deletion ameliorated the tau pathology in a mouse model of tauopathy. In particular, we found that PS19 with Mark4 knockout showed reduced mortality and memory loss compared with those bearing an intact Mark4gene. These phenotypes were accompanied by reduced neurodegeneration and astrogliosis in response to the reduction of pathological forms of tau, such as those phosphorylated at Ser356, AT8-positive tau, and thioflavin S-positive tau.
Conclusion
Our data indicate that Mark4critically contributes to tau-mediated neuropathology, suggesting that MARK4 inhibition may serve as a therapeutic avenue for tauopathies.
Research on coal mine safety risk evolution and key hidden dangers under the perspective of complex network
Authors: Su Guorui , Jia Baoshan , Shen Zhuo , Wang Peng , Hu Eryi 
Published: October 2023

Abstract

In order to find out the main causes of coal mine safety accidents and improve the pertinence of coal mine safety risk management and control, the identification and analysis of coal mine safety risks and hidden dangers are carried out based on the analysis of coal mine accident reports. And combing the complex network theory A complex network model for the evolution of coal mine safety risks is constructed. The key elements that affect coal mine safety risk accidents are obtained through quantitative research on the characteristic indicators of the complex network model of coal mine safety risks. And the key nodes of coal mine safety risk spread network are obtained through network interference to the overall efficiency. The research results show that the complex network of coal mine safety risks illustrate the characteristics of a small-world network, and the spread of a certain risk is likely to cause coal mine safety accidents. Strengthening the risk management and control of hidden dangers with higher intermediate centrality can isolate the spread of coal mine safety risks and reduce the possibility of coal mine accidents.
Construction of recombinant LSDV fluorescent virus for high-throughput screening of antiviral drugs
Authors: Wang Jingyu , Ji Jinzhao , zhong yongcheng , meng wenxin , Wan shaobing , Ding Xiaoqing , chen zihan , wu weiyong , Jia Kun , Li Shoujun 
Published: October 2023

Abstract
Lumpy skin disease virus (LSDV) infection is a major socio-economic issue that can cause serious threat to the global cattle farming industry. Here, a recombinant virus LSDV-ΔTK/EGFP of expressing EGFP was constructed using a homologous recombination system and applied to high-throughput screening of antiviral drugs. LSDV-ΔTK/EGFP can replicate in various kidney cell lines to consistent with wild-type LSDV. At the same time, the cytopathic effects, virus particle morphology, and growth performance caused by LSDV-ΔTK/EGFP are consistent with those of wild LSDV. High-throughput screening found that emodin (for LSDV-ΔTK/EGFP, IC50 = 10.86 µM), aloe emodin (for LSDV-ΔTK/EGFP, IC50 = 10.13 µM), theaflavin (for LSDV-ΔTK/EGFP, IC50 = 10.05 µM), 4-ethylphenol (for LSDV-ΔTK/EGFP, IC50 = 32.17 µM), tulipalin (for LSDV-ΔTK/EGFP, IC50 = 28.58 µM) and anemoside B4 (for LSDV-ΔTK/EGFP, IC50 = 845.65 µM) inhibited LSDV replication. Theaflavin strong inhibitory effect on LSDV was identified from 100 antiviral drugs in vitro. In addition, the addition time measurement shown that theaflavins play a role in the entry of LSDV into cells and subsequent viral replication stages. The development of this recombinant virus contributes to the development of LSDV antiviral drugs and the subsequent study of virus replication and mechanism of action.
Aging affects regrowth of stealth peritoneal dissemination of advanced ovarian cancer: A multicenter retrospective cohort study
Authors: Fujimoto Hiroki , Yoshihara Masato , Ricciardelli Carmela , Tano Sho , Iyoshi Shohei , Miyamoto Emiri , Mogi Kazumasa , Hayashi Maia , Hayakawa Sae , Nomura Satoshi , Kitami Kazuhisa , Uno Kaname , Yoshikawa Nobuhisa , Emoto Ryo , Matsui Shigeyuki , Kajiyama Hiroaki 
Published: October 2023

Abstract

Aging contributes to a worse prognosis in advanced ovarian cancer patients with peritoneal dissemination that was completely resected in the debulking surgery.
Ovarian cancer (OvCa) is one of the most lethal gynecological malignancies, and most patients are diagnosed at advanced stage with peritoneal dissemination. Although age at diagnosis is considered an independent prognostic factor, its impact on peritoneal recurrence after combined cytoreductive surgery and chemotherapy is not clear. The objective of this study was to investigate the impact of aging on peritoneal recurrence from stealth dissemination and gain insight of the pathophysiology of OvCa in elderly patients. A total of 243 patients with pT2b-pT3 epithelial ovarian who achieved complete surgery, no-residual tumor at first surgery, were selected to be analyzed the risk of peritoneal seeding and recurrence. We found that age over 65 years was independently associated with an increased risk of peritoneum-specific (PS) recurrence Furthermore, pT3 stages and positive ascites cytology also worsen the PS-recurrence-free survival. Collectively, our findings suggest that age, especially over 65 years, predicts reduced peritoneum-specific tumor recurrence in patients with advanced OvCa after complete cytoreduction surgery, particularly those with pT3 tumors and positive ascites cytology.
The Cost of Hereditary Pediatric Cataract's Clinical and Genetic Diagnosis With Whole Exome Sequencing From a Middle-income Country Perspective: Can We See Any Gains?
Authors: Neves Luiza M. , Pinto Márcia , Zin Olívia A. , Cunha Daniela P. , Agonigi Bruna N. S. , Motta Fabiana L. , Gomes Leonardo H. F. , Horovitz Dafne D. G. , Almeida Daltro C. , Malacarne Jocieli , Guida Leticia , Braga Andressa , Carvalho Adriana Bastos , Eduardo Pereira , Rodrigues Ana Paula S. , Sallum Juliana M. F. , Zin Andrea A. , Vasconcelos Zilton F. M. 
Published: October 2023

Abstract

Up to 25% of pediatric cataract cases are inherited. There is scarce information in the literature regarding the cost of whole exome sequencing (WES) for hereditary pediatric cataract. Molecular diagnosis of hereditary pediatric cataract is important for a comprehensive genetic counseling. We performed a partial economic evaluation using a microcosting approach with a bottom-up technique to estimate the cost of clinical and genetic diagnosis using WES for hereditary pediatric cataract under the Brazilian governmental healthcare system’s perspective. One hundred and ten participants from twenty-nine families from Rio de Janeiro city (RJ) were included. Direct costs of consumables, staff and equipment were used. Two scenarios were created: 1. Reference scenario included patients with hereditary pediatric cataract plus two family members in RJ. 2. Alternative scenario considered other genetic diseases resulting in 5,280 exams per month. Sensitivity analysis was performed. In the reference scenario the total cost per exam (clinical and genetic) was 609.51 United State Dollars (USD) and in the alternative scenario it was 541.20 USD. Considering only WES, its cost per exam was 455.29 USD in the reference and 386.98USD in the alternative scenarios. Sensitivity analysis showed that the most important costs were consumables in both scenarios. Economic evaluations can help inform policy decisions specially in middle-income countries such as Brazil.