bluuebunny/crossref_metadata_2025_split huggingface dataset:
Maternal Obesity Modulates Cord Blood Concentrations of Proprotein Convertase Subtilisin/Kexin-type 9 Levels
Authors: Rallis Dimitrios , Papathanasiou Aimilia Eirini , Christou Helen 
Published: February 2024

Abstract

Context
In utero exposure to maternal obesity or diabetes is considered a pro-inflammatory state.

Objective
To evaluate whether cord blood proprotein convertase subtilisin/kexin-type 9 (PCSK9), which is regulated by inflammation and metabolic derangements, is elevated in neonates born to overweight, obese, or diabetic mothers.

Methods
A retrospective study in full-term neonates born between 2010 and 2023, at Brigham and Women's Hospital. There were 116 neonates included in our study, of which 74 (64%) were born to overweight/obese mothers and 42 (36%) were born to nonoverweight/nonobese mothers.

Results
Neonates born to overweight/obese mothers had significantly higher cord blood concentrations of PCSK9 compared with neonates born to nonoverweight/nonobese group (323 [253-442] ng/mL compared with 270 [244-382] ng/mL, P = .041). We found no significant difference in cord blood concentrations of PCSK9 between neonates of diabetic mothers compared with neonates of nondiabetic mothers. In multivariate linear regression analysis, higher cord plasma PCSK9 concentration was significantly associated with maternal overweight/obesity status (b = 50.12; 95% CI, 4.02-96.22; P = .033), after adjusting for gestational age, birth weight, male sex, and intrauterine growth restriction.

Conclusion
Neonates born to mothers with overweight/obesity have higher cord blood PCSK9 concentrations compared with the nonoverweight/nonobese group, and higher cord blood PCSK9 concentrations were significantly associated with maternal overweight/obesity status, after adjusting for perinatal factors. Larger longitudinal studies are needed to examine the role of PCSK9 in the development of metabolic syndrome in high-risk neonates born to overweight, obese, or diabetic mothers.
Time Thresholds for Using Pressure Reactivity Index in Neuroprognostication for Patients With Severe Traumatic Brain Injury
Authors: Chang Jason J. , Kepplinger David , Metter E. Jeffrey , Kim Yongwoo , Trankiem Christine T. , Felbaum Daniel R. , Mai Jeffrey C. , Mason Robert B. , Armonda Rocco A. , Aulisi Edward F. 
Published: February 2024

BACKGROUND AND OBJECTIVES:
Severe traumatic brain injury (sTBI) represents a diffuse, heterogeneous disease where therapeutic targets for optimizing clinical outcome remain unclear. Mean pressure reactivity index (PRx) values have demonstrated associations with clinical outcome in sTBI. However, the retrospective derivation of a mean value diminishes its bedside significance. We evaluated PRx temporal profiles for patients with sTBI and identified time thresholds suggesting optimal neuroprognostication.

METHODS:
Patients with sTBI and continuous bolt intracranial pressure monitoring were identified. Outcomes were dichotomized by disposition status (“good outcome” was denoted by home and acute rehabilitation). PRx values were obtained every minute by taking moving correlation coefficients of intracranial pressures and mean arterial pressures. Average PRx trajectories for good and poor outcome groups were calculated by extending the last daily averaged PRx value to day 18. Each patient also had smoothed PRx trajectories that were used to generate “candidate features.” These “candidate features” included daily average PRx's, cumulative first-order changes in PRx and cumulative second-order changes in PRx. Changes in sensitivity over time for predicting poor outcome was then evaluated by generating penalized logistic regression models that were derived from the “candidate features” and maximized specificity.

RESULTS:
Among 33 patients with sTBI, 18 patients achieved good outcome and 15 patients had poor outcome. Average PRx trajectories for the good and poor outcome groups started on day 6 and consistently diverged at day 9. When targeting a specificity >83.3%, an 85% maximum sensitivity for determining poor outcome was achieved at hospital day 6. Subsequent days of PRx monitoring showed diminishing sensitivities.

CONCLUSION:
Our findings suggest that in a population of sTBI, PRx sensitivities for predicting poor outcome was maximized at hospital day 6. Additional study is warranted to validate this model in larger populations.
Improved Selectivity in Eliciting Evoked Electromyography Responses With High-Resolution Spinal Cord Stimulation
Authors: Berwal Deepak , Quintero Alejandra , Telkes Ilknur , DiMarzio Marisa , Harland Tessa , Paniccioli Steven , Dalfino John , Iyassu Yohannes , McLaughlin Bryan L. , Pilitsis Julie G. 
Published: February 2024

BACKGROUND AND OBJECTIVES:
As spinal cord stimulation (SCS) offers a therapy for increasing numbers of patients with chronic pain and spinal cord injury, it becomes increasingly important to better understand its somatotopy. In this prospective study, we investigate whether high-resolution SCS (HR-SCS) offers improved selectivity assessed through elicitation of evoked electromyography (EMG) responses as compared with commercial paddle leads.

METHODS:
Vertical tripole configurations were used to elicit EMG responses in both types of paddles placed for standard-of-care indications between T6 and T10. In HR-SCS, evoked EMG responses in lower extremity/abdominal muscle groups were monitored at 6 to 8 mediolateral sites. All commercial paddle columns were tested. Percentage change in the maximum root mean square value was calculated at a group level. Heat maps were generated to identify responders for each muscle group. Responders were considered patients who had a >50% change in root mean square over baseline.

RESULTS:
We demonstrated significantly greater motor responses across medial and lateral contacts and greater responder rates consistently at the T6 and T9 levels with HR-SCS as compared with commercial paddles in 18 patients. Distal muscle groups (gastrocnemius and tibialis anterior) and proximal muscle groups (biceps femoris and quadriceps) were selectively activated at both levels.

CONCLUSION:
We demonstrate that HR-SCS has greater selectivity in eliciting evoked EMG responses in an intraoperative setting. HR-SCS offers recruitment of muscle groups at lateral contacts concurrently with medial contacts. We provide data that HR-SCS may provide higher spatial resolution, which has the potential to allow for personalization of care and treatment of pain syndromes/symptoms which to date have not been effectively treated.
Development and Calibration of a PATCH Device for Monitoring Children’s Heart Rate and Acceleration
Authors: Armstrong Bridget , Weaver R. Glenn , McAninch Jonas , Smith Michal T. , Parker Hannah , Lane Abbi D. , Wang Yuan , Pate Russ , Rahman Mafruda , Matolak David , Chandrashekhar M. V. S. 
Published: February 2024

ABSTRACT

Introduction
Current wearables that collect heart rate and acceleration were not designed for children and/or do not allow access to raw signals, making them fundamentally unverifiable. This study describes the creation and calibration of an open-source multichannel platform (PATCH) designed to measure heart rate and acceleration in children ages 3-8 years.

Methods
Children (N = 63; Mean age = 6.3) participated in a 45-minute protocol ranging in intensities from sedentary to vigorous activity. Actiheart-5 was used as a comparison measure. We calculated mean bias, mean absolute error (MAE) mean absolute percent error (MA%E), Pearson correlations and Lin’s concordance correlation coefficient (CCC).

Results
Mean bias between PATCH and Actiheart heart rate was 2.26 BPM, MAE was 6.67 BPM and M%E was 5.99%. The correlation between PATCH and Actiheart HR was .89 and CCC was .88. For acceleration, mean bias was 1.16 mg and MAE was 12.24 mg. The correlation between PATCH and Actiheart was .96 and CCC was .95.

Conclusions
The PATCH demonstrated clinically acceptable accuracies to measure heart rate and acceleration compared to a research grade device.
Effect of Running Speed on Knee Biomechanics in Collegiate Athletes Following Anterior Cruciate Ligament Reconstruction
Authors: KNURR KEITH A. , COBIAN DANIEL G. , KLIETHERMES STEPHANIE A. , JOACHIM MIKEL R. , HEIDERSCHEIT BRYAN C. 
Published: February 2024

ABSTRACT

Introduction
Athletes after anterior cruciate ligament reconstruction (ACLR) demonstrate altered surgical knee running kinematics and kinetics compared with the nonsurgical limb and healthy controls. The effect of running speed on biomechanics has not been formally assessed in athletes post-ACLR. The purpose of this study was to characterize how knee biomechanics change with running speed between 3.5–7 (EARLY) and 8–13 (LATE) months post-ACLR.

Methods
Fifty-five Division I collegiate athletes post-ACLR completed running analyses (EARLY: n = 40, LATE: n = 41, both: n = 26) at 2.68, 2.95, 3.35, 3.80, and 4.47 m·s−1. Linear mixed-effects models assessed the influence of limb, speed, time post-ACLR, and their interactions on knee kinematics and kinetics.

Results
A significant limb–speed interaction was detected for peak knee flexion, knee flexion excursion, and rate of knee extensor moment (P < 0.02), controlling for time. From 3.35 to 4.47 m·s−1, knee flexion excursion decreased by −2.3° (95% confidence interval, −3.6 to −1.0) in the nonsurgical limb and −1.0° (95% confidence interval, −2.3 to −0.3) in the surgical limb. Peak vertical ground reaction force, peak knee extensor moment, and knee negative work increased similarly with speed for both limbs (P < 0.002). A significant limb–time interaction was detected for all variables (P < 0.001). Accounting for running speed, improvements in all surgical limb biomechanics were observed from EARLY to LATE (P < 0.001), except for knee flexion at initial contact (P = 0.12), but between-limb differences remained (P < 0.001).

Conclusions
Surgical and nonsurgical knee biomechanics increase similarly with speed in collegiate athletes at EARLY and LATE, with the exception of peak knee flexion, knee flexion excursion, and rate of knee extensor moment. Surgical knee biomechanics improved from EARLY and LATE, but significant between-limb differences persisted.
The Influence of “Super-Shoes” and Foot Strike Pattern on Metabolic Cost and Joint Mechanics in Competitive Female Runners
Authors: MARTINEZ EDUARDO , HOOGKAMER WOUTER , POWELL DOUGLAS W. , PAQUETTE MAX R. 
Published: February 2024

ABSTRACT
“Super-shoes” are designed to improve endurance running performance by reducing the metabolic demands of running. Although the research on “super-shoes” is still developing and has mostly been studied in male runners, it is not clear how possible mediating factors, such as foot strike pattern, influence the metabolic cost and joint mechanics in competitive female runners.

Purpose
The objective of this study is to assess the influence of “super-shoes” on metabolic cost and joint mechanics in competitive female runners and to understand how foot strike pattern may influence the footwear effects.

Methods
Eighteen competitive female runners ran four 5-min bouts on a force instrumented treadmill at 12.9 km·h−1 in 1) Nike Vaporfly Next% 2™ (SUPER) and 2) Nike Pegasus 38™ (CON) in a randomized and mirrored order.

Results
Metabolic power was improved by 4.2% (P < 0.001; d = 0.43) and metatarsophalangeal (MTP) negative work (P < 0.001; d = 1.22), ankle negative work (P = 0.001; d = 0.67), and ankle positive work (P < 0.001; d = 0.97) were all smaller when running in SUPER compared with CON. There was no correlation between foot strike pattern and the between-shoe (CON to SUPER) percentage change for metabolic power (r = 0.093, P = 0.715).

Conclusions
Metabolic power improved by 4.2% in “super-shoes” (but only by ~3.2% if controlling for shoe mass differences) in this cohort of competitive female runners, which is a smaller improvement than previously observed in men. The reduced mechanical demand at the MTP and ankle in “super-shoes” are consistent with previous literature and may explain or contribute to the metabolic improvements observed in “super-shoes”; however, foot strike pattern was not a moderating factor for the metabolic improvements of “super-shoes.” Future studies should directly compare the metabolic response among different types of “super-shoes” between men and women.
Mapping the HealthPathways literature: a scoping review protocol
Authors: McGlynn Anna , Ní Shé Éidín , Liaw Teng , Jackson Tony , Harris-Roxas Ben 
Published: February 2024

Objective: This scoping review will identify what literature exists on HealthPathways and make suggestions for the direction of future HealthPathways research. Background: HealthPathways is a free to access, password protected online tool containing practical, easy to use, localised clinical and referral information that is primarily aimed at GPs. HealthPathways originated in Canterbury, New Zealand in 2008. Since this time the program has spread and is being used in 50 health systems across New Zealand, Australia, and the United Kingdom (Streamliners, 2022a). Despite such large spread of the program there has been relatively little literature published on the utility, usefulness and cost-effectiveness of HealthPathways. This scoping review aims to identify and describe all current HealthPathways literature and make recommendations for the direction of future HealthPathways research. Methods: The Joanna Briggs Institute (JBI) methodology will be used to develop the scoping review. Databases included in the search include MEDLINE (PubMEd), Embase, CINAHL, Web of Science, Google Scholar, Emerald and Cochrane. The inclusion criteria are studies and grey literature on HealthPathways that are published in English, with no time limit. Grey literature will be identified through searching relevant credible organisations and websites. All results will be entered into Covidence to be assessed by two reviewers against a set tool. The PRISMA extension for scoping reviews will be used for reporting. Ethics approval is not required as only published information will be used. The research will be disseminated through publication in an open access peer reviewed journal. Conclusions: This protocol is published to make the process for the review transparent and replicable. The scoping review will highlight the extent of evidence that exists on HealthPathways and may provide direction for decision making and future research.
Effects of antioxidant supplementation for polycystic ovary syndrome
Authors: Łopacińska Olga , Stańczyk Katarzyna , Korn Aleksandra , Czarnecka Karolina , Wójcik Emilia , Korczak Anna , Jędrzejczyk Justyna , Szewczyk Oliwia , Olek Ewa , Burda Katarzyna 
Published: February 2024

Introduction and purpose: Polycystic ovary syndrome is the most common endocrinopathy in women, with a prevalence ranging from 10% to 13%. Oxidative stress and decreased antioxidant levels contribute to the development of various diseases, and one of them is polycystic ovary syndrome. The aim of this review is to provide an overview of the current knowledge about the effects of antioxidant administration in PCOS treatment.
A brief description of the state of knowledge: Oxidative stress is an imbalance between increased levels of reactive oxygen species and a decreased efficiency of antioxidant mechanisms, which can potentially cause damage. The harmful effects of free radicals might be neutralized by antioxidants obtained from the diet, such as polyphenols, vitamins C, and E. These compounds improve several aspects of the PCOS pathomechanism, including hormonal imbalance, glucose metabolism, lipid profile, and ovarian functionality.
Conclusions: The outcomes of all the reviewed studies in this paper indicate that antioxidants such as resveratrol, curcumin, vitamin C and E, N-acetylcysteine, and melatonin have therapeutic potential in the management of PCOS. However, currently antioxidant therapies cannot be recommended in PCOS therapy since there is a need for more prospective randomized clinical trials on a larger sample to establish a long-term effects of antioxidants supplementation in PCOS, the optimal dosage, and finally to assess which antioxidant is the most efficient in PCOS treatment.
Vínculos entre movimientos sociales y partidos políticos, y su impacto electoral en el contexto del estallido social en Bolivia, 2019-2020
Authors: Valdivia Rivera Soledad 
Published: February 2024

El análisis sobre estallidos sociales suele enfocarse en el interior de la movilización social. Tomando el caso del estallido social en Bolivia en 2019, este artículo explora, más bien, los vínculos entre movimientos sociales y partidos políticos, y su efecto en el desempeño electoral. Los movimientos sociales jugaronun papel importante al construir las condiciones para el estallido y marcar la evolución de la crisis hacia su resolución. Dada su cercanía en el tiempo, las elecciones de 2019 y 2020 presentan una oportunidad particular para estudiar el efecto electoral de las vinculaciones en el contexto del estallido social. Se analizan cuatro conexiones entre movimientos sociales y partidos políticos: Movimiento al Socialismo, Comunidad Ciudadana, Bolivia dice No y Creemos. El artículo identifica y explora las diferencias cualitativas entre estas conexiones —que varían entre partido orgánico, partido movimiento y alianzas circunstanciales—, las cuales se relacionan con los resultados electorales, disimiles al momento de considerar el escenario político en que operan. Este trabajo sugiere que, la vinculación de los vehículos electorales con movimientos sociales y organizaciones de la sociedad civil emerge como condición de éxito electoral en la contienda boliviana, en un escenario en el que la protesta social se constituye en canal convencional de participación política y articulación de demandas ciudadanas.
Strategic Content Generation and Monetization in Financial Social Media
Authors: Li Ding , Goh Khim-Yong , Heng Cheng-Suang 
Published: February 2024

Strategic Content Generation and Monetization in Financial Social MediaAbstractFinancial social media, which relies on social media analysts (SMAs) to contribute content to investors, is a crucial channel for investors to gain financial information and for SMAs to monetize their content. The interactive nature of financial social media has given SMAs the opportunity to gain access to the investor preferences of their own audience base for financial content. Our study documents that SMAs would exploit this opportunity to strategically generate and monetize content by catering to investor preferences. Specifically, SMAs would increase the (negative) sentiment of the content if paid subscribers’ preferences for (negative) sentiment grow. Additionally, an SMA is more likely to produce paid content when the expected free readership increases and is less likely to do so when the expected paid subscriptions increase. Our findings suggest that the sentiment of financial social media content is not a mere reflection or prediction of stock market movements but also a result of SMAs’ reaction to investor preferences. We thus illustrate an approach to identify the SMAs who may amplify the investors’ confirmation biases because of such catering behaviors so that platform managers and regulators alike can utilize this method to improve the content quality of financial social media.
A generalization of Hardy’s inequality to infinite tensors
Authors: Saheli Morteza , Foroutannia Davoud , Yusefian Sara 
Published: February 2024

Abstract
In this paper, we extend Hardy’s inequality to infinite tensors. To do so, we introduce Cesàro tensors

ℭ

{\mathfrak{C}}

, and
consider them as tensor maps from sequence spaces into tensor spaces. In fact, we prove inequalities of the form

∥

ℭ
⁢

x
k

∥

t
,
1

≤

U
⁢

∥
x
∥

l
p

k

\|\mathfrak{C}x^{k}\|_{t,1}\leq U\|x\|_{l_{p}}^{k}

(

k
=

1
,
2

k=1,2

),
where x is a sequence,

ℭ
⁢

x
k

{\mathfrak{C}x^{k}}

is a tensor, and

∥
⋅

∥

t
,
1

{\|\cdot\|_{t,1}}

,

∥
⋅

∥

l
p

{\|\cdot\|_{l_{p}}}

are the tensor and sequence norms, respectively. The constant U is independent of x, and we seek the smallest possible value of U.
The crystal structure of bis(1,4,7,10,13-pentaoxacyclopentadecane)-potassium(I) dichloridocopper(I), C20H40Cl2CuKO10
Authors: Qi Ji , Bai En-Ying , Zhang Chun-Ting 
Published: February 2024

Abstract
C20H40Cl2CuKO10, triclinic,

P

1
‾

$P\overline{1}$

(no. 2), a = 9.0148(5) Å, b = 9.3066(5) Å, c = 17.7296(10) Å, α =

78.383

(
2
)

°

$78.383(2){}^{\circ}$

, β =

88.488

(
2
)

°

$88.488(2){}^{\circ}$

, γ =

72.982

(
2
)

°

$72.982(2){}^{\circ}$

, V = 1392.35(13) Å3, Z = 2, R

gt
(F) = 0.0781, wR

ref
(F
2) = 0.2089, T = 170(2) K.
Rekonstrukcija putničke luke i uređenje obale Riva u Rijeci od 1945. do 1960. godine
Authors: Butković Mićin Lidija 
Published: February 2024

U Drugom svjetskom ratu riječko-sušačka luka doživjela je devastirajuća razaranja koja su velikim materijalnim ulaganjima postupno sanirana do sredine 60-ih godina 20. stoljeća. Rekonstrukcija putničke luke i obale Riva (tadašnja Obala jugoslavenske mornarice) predstavljala je iznimku jer se nije težilo vratiti predratno stanje, već iskoristiti jedinstvenu priliku da se provedu prostorne korekcije u cilju uspješnijeg suživota grada i luke. Zalaganjem niza stručnjaka koji su u različitim fazama bili uključeni u projekt (ing. Yvonne Clerici, ing. Zdenko Kolacio, ing. Zdenko Sila, ing. Dragutin Adam i drugi), do 1960. godine putnička luka je povećana izvedbom novog Gata 29. novembar (danas Gat Karoline Riječke), obalni pojas od Žabice do Rive Boduli proširen je radi prostornog razgraničenja različitih vrsta prometa, dobio je suvremenu infrastrukturu i javnu rasvjetu, oplemenjen je drvoredima i novim gradskim parkom. Izrađeni su i planovi za neostvarene investicije, poput parobrodarske putničke stanice i reprezentativnog gradskog hotela koji je smjerao transformirati maritimnu fasadu Rijeke. U članku je prezentirana kronologija projekta, procesi odlučivanja i rezultati urbanističko-arhitektonskih zahvata.
Enhancing pier local scour prediction in the presence of floating debris
Authors: Al-Jubouri Muhanad , Ray Richard P. 
Published: February 2024

AbstractLocal scour poses a grave threat to bridge foundations, potentially causing catastrophic collapses. This study uses FLOW-3D with the Reynolds-Averaged Navier-Stokes model to analyze pier scour and dune formation under bridges. It focuses on submerged debris shapes near the water's surface. Results closely match experiments when specific conditions are met. The study introduces an innovative approach to debris impact assessment. Instead of traditional methods, it proposes a novel equation accounting for debris's effective area and elevation. This enhances reliability by over 20%, improving scour depth assessment in debris-laden scenarios. This advances the understanding of debris's role in local scour, benefiting bridge design and management practices.
Synthesis and characterization of aluminum-doped graphitic carbon
Authors: Gordon Isabelle P. , Suenram Grace , McGlamery Devin , Stadie Nicholas P. 
Published: February 2024

AbstractHeteroatom doping of graphitic carbon is of high interest for tuning its physicochemical properties. Aluminum is commonly reported as a high-interest dopant, but few synthetic strategies have been reported owing to the low equilibrium solubility of Al within graphite. Herein we report several strategies to achieve metastable aluminum-substituted turbostratic graphitic carbon materials with aluminum contents up to ~ 0.5 at%, via co-pyrolysis of two molecular precursors between 800 and 1100°C. The resulting materials exhibit turbostratic graphitic structure and a previously unreported aluminum environment detectable by X-ray absorption spectroscopy (XAS), a likely signature of trigonal planar or puckered AlC3-type sites.
Graphical abstract