bluuebunny/crossref_metadata_2025_split huggingface dataset:
WITHDRAWN: Novel FOXM1 inhibitor STL001 sensitizes human cancers to a broad-spectrum of cancer therapies
Authors: Gartel Andrei , Raghuwanshi Sanjeev , Zhang Xu , Arbieva Zarema , Khan irum , Wang Zefeng , Domling Alex , Camacho Carlos 
Published: December 2023

Abstract
Forkhead box protein M1 (FOXM1) is often overexpressed in human cancers and strongly associated with therapy-resistance and less good patient survival. The chemotherapy options for patients with the most aggressive types of solid cancers remain very limited because of the acquired drug-resistance, making the therapy less effective. Pharmacological inhibition of FOXM1 could be a promising approach to sensitize therapy-resistant cancers. Here, we explore a novel FOXM1 inhibitor STL001, a first-generation modification drug of our previously reported FOXM1 inhibitor STL427944. STL001 preserves the mode of action of the STL427944; however, STL001 is up to 50 times more efficient in reducing FOXM1 activity in a variety of solid cancers. The most conventional cancer therapies studied here observed with reduced toxicity due to the induction of FOXM1 expression in solid cancers. Interestingly, STL001 demonstrated suppression of FOXM1 activity and exhibited increased sensitivity of cancer cells to the cytotoxic effects of these drugs. Notably, STL001 does not provide further sensitization to FOXM1-KD cancer cells, suggesting that the sensitization effect is conveyed specifically through FOXM1 suppression. RNA-seq and gene set enrichment studies revealed prominent suppression of FOXM1-dependent pathways and gene ontologies. Also, gene regulation by STL001 showed extensive overlap with FOXM1-KD, suggesting a high selectivity of STL001 toward the FOXM1 regulatory network. A completely new activity of FOXM1, mediated through steroid/cholesterol biosynthetic process and protein secretion in cancer cells was also detected. Collectively, STL001 offers intriguing translational opportunities as combination therapies targeting FOXM1 activity in a variety of human cancers driven by FOXM1.
Clinical Characteristics of IgG4-related Disease: An Analysis of 166 Cases in a Taiwanese Population
Authors: Chan Tien-Ming , Yu Han-Hua , Lee Chih-Chun , Yu Kuang-Hui 
Published: December 2023

Abstract
Objectives: To scrutinize clinical attributes and associated factors of elevated serum IgG4 concentrations over an 8-year timeline in 166 patients diagnosed with IgG4-related diseases (IgG4-RD).
Methods: This study conducted retrospective analysis of medical records belonging to 2,968 adults, all of whom had participated in serum IgG4 assessments between December 2007 and August 2014.
Results: Among the 2,968 participants, we identified 166 (5.6%) having IgG4-RD, while the remaining 2,802 (94.4%) were diagnosed with other diseases; thus, forming the non-IgG4-RD cohort. We observed a significant differences in the mean serum IgG4 levels between the IgG4-RD group (average: 1087.5 mg/dL, median: 597.0, range: 15–6790 mg/dL) and the non-IgG4-RD cohort, (average: 104.1 mg/dL, median: 75.0, range: 1–4400 mg/dL; p < 0.0001). The patients with IgG4-RD had a mean age of 58.5 ± 15.9 years, ages ranging from 21 to 87 years, and the group was predominantly male (71%.) Autoimmune pancreatitis (AiP) did not present in 87 (52.4%) of the IgG4-RD cases, termed non-AiP IgG4-RD, while 27 patients (16.3%) had AiP with other organ involvement (OOI). Elevated serum IgG4 levels (>135 mg/dL) were detected in 143 (86.1%) of the IgG4-RD patients, in contrast with 652 (23.3%) in the non-IgG4-RD group (p < 0.001). An optimal IgG4 diagnostic threshold for IgG4-RD was determined at 222 mg/dL.
Conclusions: In this cohort, we found that non-AiP IgG4-RD represented more than half of the diseases linked to IgG4-RD. The symptoms of IgG4-RD in our group covered an extensive range of organ systems. Further, the optimal diagnostic cutoff for IgG4 was determined through nephelometry via a Siemens BN ProSpec device and Siemens reagent, established at 222 mg/dL.
Clinical usefulness of the serum-soluble transferrin receptor in functional iron deficiency associated with long-term hemodialysis
Authors: Motomiya Yoshihiro , Kaneko Yoshiteru , Higashimoto Yuichiro 
Published: December 2023

Abstract
Background
Soluble transferrin receptor (sTfR) was reported to be a valuable diagnostic marker for functional iron deficiency (FID). Hepcidin, which is a key regulator of iron metabolism, has been shown to have increased values in patients undergoing hemodialysis (HD). Thus, we measured serum levels both of sTfR and hepcidin in 97 HD patients and investigated the clinical value of these measures.
Methods
We used a commercial enzyme-linked immunosorbent assay kit to measure serum levels both of hepcidin and sTfR.
Results
Although serum sTfR levels did not clearly increase, both sTfR levels and its index value correlated with the saturation of transferrin, erythropoietin-stimulating agent dosage, and erythropoietin resistance index (ERI). In addition, a strong negative correlation was found for sTfR and log serum hepcidin values.
Conclusions
Serum sTfR levels and the sTfR index were acceptable markers for FID and ERI even in patients undergoing HD whose serum levels of hepcidin increased.
Categorical equivalences for Hopf trusses and their modules
Authors: Rodríguez Ramón González , Raposo Ana Belén Rodríguez 
Published: December 2023

Abstract

In this paper we introduce the notion of generalized invertible 1-cocycle in a strict braided monoidal category C, and we prove that the category of Hopf trusses is equivalent to the category of generalized invertible 1-cocycles. On the other hand, we also introduce the notions of module for a Hopf truss and for a generalized invertible 1-cocycle. We prove some functorial results involving these categories of modules and we show that the category of modules associated to a generalized invertible 1-cocycle is equivalent to a category of modules associated to a suitable Hopf truss. Finally, assuming that in C we have equalizers, we introduce the notion of Hopf-module in the Hopf truss setting and we obtain the Fundamental Theorem of Hopf modules associated to a Hopf truss.
2020 Mathematics Subject Classification: 18M15, 16T05.
Coral reef restoration in Indonesia: lessons learnt from the world’s largest coral restoration nation
Authors: Watt-Pringle Rowan , Razak Tries Blandine , Jompa Jamaluddin , Rappe Rohani Ambo , Nadhira Alyssa , Smith David J. 
Published: December 2023

Abstract

Indonesia is the global coral reef restoration leader by number of projects, yet these remain diverse and disparate. This study reviews the status of Indonesian coral reef restoration and current best practice (CBP) through the lens of international CBP as defined by the National Oceanic and Atmospheric Administration manager’s guide for reef restoration planning and design, providing suggestions for a formal network of reef restoration practitioner network to develop and implement a national restoration roadmap. Surveyed projects were identified from existing reef restoration networks and databases and using online search engines. Responses were obtained from 45 projects with whom interviews were conducted to determine alignment with international CBP. There is particular scope to increase quantitative data collection, reinforce community involvement, and improve ecological data collection. While 84% of projects reported quantifiable goals, 64% didn’t quantify goals during planning and 61% didn’t incorporate climate smart design features. Quantitative reef monitoring surveys were absent in 22% of projects. Important ecological metrics including coral community composition/diversity (96%), coral health/bleaching (89%), benthic community (62%), and coral survival (62%) weren’t quantified by long-term monitoring in the majority of projects. Indonesia has the capacity, regulations, and networks to position itself as reef restoration driver in the Coral Triangle region, but this will require countrywide coordination, alignment, and quantification of restoration. A structured, collaborative and iterative national network of government authorities, decision-makers, and reef restoration managers, practitioners, and researchers, could facilitate the development of a national restoration roadmap, including a tiered system to standardise project planning, monitoring, and reporting, and greater focus on climate change adaptation goals.
Chemical Quantification of CBD and THC and Bacteriological Analysis of Artisan Cannabis Sativa Extracts: TheImportance of Regulation
Authors: Costa Pâmela Aparecida da , Júnior Linério Ribeiro de Novais , Silva Larissa Mendes da , Scussel Rahisa , De Pieri Ellen , Ramos Suelen de Souza , Kock Kelser de Souza , Amaral Patrícia de Aguiar , Rigo Flávia Karine , de Ávila Ricardo Andrez Machado , de Bitencourt Rafael Mariano 
Published: December 2023

Abstract
Objectives
Cannabis sativa is a plant species that has been used for millennia, especially in medicinal form, due to its great therapeutic potential. Tetrahydrocannabinol (THC) and cannabidiol (CBD) are the main pharmacologically active substances found in the plant. Efficient methods of extraction, purification and, sometimes, the separation of these cannabinoids are necessary to obtain extracts and compounds that can be used in the search for safe and effective therapeutic responses.
Methods
In this work, it was possible to analyze the composition of cannabinoids in 41 extracts of Cannabis sp. (32 produced by associations and 9 produced by the patients themselves), determining the amount of THC and CBD in the samples, using the High Performance Liquid Chromatography technique (RP-HPLC), as well as the presence of bacteria, using the Gram method.
Results
The median concentrations of THC and CBD measured in the samples were 51% and 58%, lower than the expected concentration, respectively. Furthermore, the presence of a Gram positive microorganism was observed in only one sample, suggestive of Staphylococcus Aureus.
Conclusion
Although associations have a noble social function, quality control in the production of medicines is important, with proper titration of cannabinoids and microbiological analysis of samples, which can be implemented through regulation by the Public Power.
Social Capital and Quality of Life among the Refugees residing in Mbarara City Southwestern Uganda
Authors: Kakai Brenda , Bahati Ronald , Otwine Anne , Nzamuhiki Steven , Ainamani Herbert 
Published: December 2023

Abstract
Introduction:
Globally, social capital is considered a significant resource in improving quality of life among human beings. In this study, we aimed at assessing the proportions of forms of social capital and their association with the quality of life among the refugees living in Mbarara City southwestern Uganda.
Methods
This cross-sectional study used consecutive sampling method to select 344 refugees that were living in Mbarara city at the time of data collection. Refugees were assessed on their social capital using the World bank Social Capital Integrated Questionnaire. Quality of life was assessed using the World Health Organization questionnaire of quality of life. Data were analyzed using STATA. Descriptive statistics determined the occurrence of social capital while linear regression model determined the association between social capital and quality of life.
Results
Almost all participants endorsed one form of social capital, with majority of the participants [251(73%)] endorsing sociability, followed by trust and solidarity 186(54%), groups and networks were the least endorsed [170(49%)] within our sample. Our findings further showed that having high levels of trust and solidarity, positively correlated with quality of life (b = 0.80; 95% CI, 0.09 to 1.51; p = 0.027).
Conclusions
High social capital is likely to be associated with quality of life among refugees. Interventions aimed at building strong social capital are encouraged.
SSB-2548 Attenuates C-X-C chemokine receptor type 4 (CXCR-4) Activation to Induce Apoptosis; An in silico Guided invitro Validation in Acute Myeloid Leukemia cells
Authors: Dera Ayed A. 
Published: December 2023

Abstract

Background and Aim:
The role of C-X-C chemokine receptor type 4 (CXCR-4) in chemotherapy resistance remains crucial in promoting proliferation, invasion and progression in Acute Myeloid Leukemia (AML) cells. This study aims to screen and investigate a potential lead candidate as a therapeutic agent targeting CXCR-4 in AML cells.
Methods
Diversity-based virtual screening process using Autodock-vina was employed to screen approximately 8,50,000 compounds from the ChemBridge-small molecule database. The binding stability and dynamics was investigated through GROMACS-based molecular dynamics simulations and RMSD. AML cells (THP-1, HL-60 and SKM-1cell cell lines) was used to assess proliferation CXCR-4 expression and apoptosis induction were measured using flow cytometry and trans-endothelial migration was assessed using calorimetric method in AML cells. The ADME properties were predicted using SwissADME server.
Results
The computational evaluations revealed SSB-2548 as a lead candidate that binds stably to CXCR-4. Molecular dynamics simulations provided detailed insights into the conformational changes of the SSB-2548/CXCR-4 complex. The compound inhibited the THP-1, HL-60 and SKM-1cell proliferations with GI50 values of 84.57 nM, 41.30 nM and 120.50 nM respectively. SSB-2548 decreased the trans-endothelial migration and CXCR-4 expression in while inducing early and late phase apoptosis in all three AML cell types. ADME predictions indicated a favorable lead-likeness, gastrointestinal absorption and lack of notable toxicity.
Conclusion
Computational assessments identified SSB-2548 as a novel CXCR-4 inhibitor. Invitro evaluations proved this lead compound effective against AML cells. These findings lay the groundwork for future investigations positioning SSB-2548 as a candidate for the development of targeted therapies against AML.
Species of Fusarium fujikuroi complex causing seed and seedling rot of Baru (Dipteryx alata Vogel) in Brazil
Authors: Marques Eder , Silva Moisés Rodrigues , Rios Emilly Ferreira Braga , Luz Geovana Guimarães , Costa Isabela Gomes Ferreira da , de Souza Eli Regina Barboza , Cunha Marcos 
Published: December 2023

Abstract
Baru (Dipteryx alata Vogel) is a plant native to the Brazilian Cerrado and has numerous uses. In October 2022, Baru seedlings were received at the NPF plant disease diagnosis clinic, Universidade Federal de Goiás. These plants showed symptoms of stem lesions and apical death, in addition to rotten seeds. To investigate the cause of the disease, isolation was initially carried out on potato dextrose agar medium, and 30 conidia were measured. Then, the pathogenicity test was conducted on Baru seedlings and seeds. Molecular characterization was performed by partial sequencing of act, its, rpb2 and tef1-α markers and concatenated phylogenetic analysis by Bayesian inference. Based on the isolations, it was observed that the mycelium presented a cotton-like appearance in culture, from pink to purple. The microconidia were ellipsoid, unicellular, and ranged from 5.224 to 12.773 µm x 2.250 to 4.532 µm. In the pathogenicity test, apical death of seedlings, lesions and seed rot were observed. In the laboratory test, the appearance of depressed lesions on the seed coat, cotyledons, stem, and roots was observed, from which it was also possible to recover the fungi, fulfilling Koch's postulates. The molecular identification revealed that the isolates belong to the species Fusarium sacchari and F. musae. To our knowledge, this is the first report of them associated with rot of Baru seeds and seedlings in Brazil.
Hip-knee-ankle physiotherapy for the improvement of the lower limb ’ s biomechanical environment in knee disorders: A literature review
Authors: Zhang Yusheng , Liu Yang , Jin Liang 
Published: December 2023

Abstract

Purpose：To analyse the research conducted in recent years on conservative treatment modalities for various knee joint, to provide a correct orientation for hip-knee-ankle lower limb force line correction methods, and to provide a theoretical basis for the creation of an excellent mechanical environment for the knee joint, a reasonable joint space, and a neutral movement trajectory that allows for sustainable and safe treatment.
Methods：Literature was searched from the electronic databases PubMed, Scopus, and China Knowledge Internet (CNKI), Wanfang Data (WD), and China Biomedical Literature Database (CBM) to identify studies that used physiotherapy to treat knee-related disorders during the period from January 2018 to January 2023. Ultimately, 19 randomized controlled trial studies were included, involving a total of 1022 clinical studies.
Results：In the ankle and foot region, improvements in lower limb biomechanics can be achieved through the use of customized insoles, gait correction training, and ankle function and strength training. At the knee joint, various training modalities such as concentric and eccentric training, electrical nerve stimulation, and blood flow restriction training can be employed to enhance the strength and flexibility of the quadriceps muscles, thereby improving lower limb strength and stability, and promoting a favorable mechanical environment for the joints. At the hip joint, increasing strength in hip external rotation and abduction, along with the use of acupuncture and massage therapy, can be employed to alleviate joint pain and enhance control over the lower limbs.
Conclusions：Physically adjusting the hip-knee-ankle joint can treat knee-related disorders by progressively correcting the aberrant lower limb force lines and improving the symptoms of knee-related disorders.
Experimental and Large Eddy Simulation Study of Slot Jet Impingement Cooling from Heated Cylinder placed on Flat Plate
Authors: Ganatra Ketan Atulkumar , Singh Dushyant , Mukhopadhyay Achintya 
Published: December 2023

Abstract

The present study focuses on experimental investigation and numerical study using Large Eddy Simulation (LES) for an air impinging jet flow. The investigation is carried out for slot jet impingement on heated cylinder with provision of adiabatic flat plate beneath the heated cylinder. The parametric investigation is conducted for parameters such as Reynolds number (Re), jet to cylinder spacing (h/S), surface curvature (S/D) and plate length (P/D). They are varied as Re = 10,000 – 25,000; h/S = 4 – 12, S/D = 0.072 – 0.108 and P/D = 0.5 – 2. The Nusselt number distribution over cylinder is experimentally obtained and to understand the impact of parameters such as Re, h/S, S/D and P/D on it; the numerical results are extracted from LES. The Nusselt number improves with increasing Re and decreasing h/S, although their impacts are not same. The major influence of Re and h/S is noticeable from θ = 0o – 180o and θ = 0o – 90o; however impact of h/S is very negligible from θ = 90o – 180o. The Nusselt number increases with increasing S/D due to more air entrainment which produces higher Reynolds stress and turbulence kinetic energy. The increasing plate length (P/D) shifts flow separation at lower angular position (θ) thereby increasing recirculation zone and reducing attached flow region. The recirculation zone contributes to heat transfer improvement in that region. Hence longer plate length P/D = 2 is ideal selection of plate length compared to P/D = 0.5 and 1 as it better facilitates positioning of cylindrical food product with optimum heat transfer.
Cutaneous application of SecurePig® FLASH, a Pig Appeasing Pheromone analogue, facilitates adaptation and manages social behavior during feeding in semi-extensive conditions
Authors: Chasles Manon , Marcet‑Rius Míriam , CHOU Jen-Yun , Teruel Eva , Pageat Patrick , Cozzi Alessandro 
Published: December 2023

Abstract
Background
Farm animals face several challenges throughout their lives, which can affect both their welfare and their productivity. Promoting adaptation in animals is one way of limiting these consequences. In various animal species, the use of maternal appeasing pheromones is efficient to reduce aggressiveness, improve adaptation and thus ensuring better welfare and productivity. This study sought to investigate the efficiency of a treatment with a Pig Appeasing Pheromone (PAP) on the behavior of pigs reared under semi-extensive conditions and exposed to a potential conflict – collective feeding. Animals (n = 14 divided in 2 groups of 7) were subjected to 3 different phases, A) baseline - no pigs received the PAP, B) SP − 2 out of the 7 pigs per group received the PAP and C) AP – all pigs received the PAP. Behaviors related to feeding, aggression and locomotion were compared between the 3 phases of the study.
Results
Compared to the baseline period, we observed that the number of head knocks was reduced when some pigs (p < 0.001) and all pigs (p < 0.005) received the PAP. Similarly, we observed that the number of fleeing attempts was reduced when some pigs (p < 0.001) and all pigs (p < 0.001) were treated when compared to baseline. This number was lower in the AP phase than in the SP phase (p < 0.001). When all pigs were treated (AP), we also observed that they spent less time investigating the floor than during the two other phases (p < 0.001), but they seemed more likely to leave the feeder due to the presence or behavior of another pig of the group (SP vs AP, p < 0.05; Baseline vs AP, p = 0.06).
Conclusions
The PAP application improved adaptation in pigs by reducing aggressiveness and promoting conflict avoidance. Those results validate the efficiency of the pheromonal treatment under semi-extensive rearing conditions to help pigs to cope with a challenging situation. Using PAP in the pig industry seems interesting to limit unwanted consequences of farm practices on animal welfare and productivity, by promoting their adaptation.
The exploration of a new technology: preservation of immovable silicate cultural relics against salt efflorescence by directional induction of water and salt migration
Authors: Li Qiang , Gao Ge , Yang Longkang , Huang Xiao , Luo Hongjie 
Published: December 2023

Abstract
Salt efflorescence is one of the critical problems for the preservation of immovable silicate relics. Salt efflorescence mainly comes from continuous cycles of crystallization/dissolution or hydration/dehydration of salts in confined pores in silicate relics. Many protocols have been developed in attempts to alleviate possible salt damages with minor success because of endless water and salt feed from underground. In this study, we propose and design a novel technique for salt damage prevention and protection of immovable relics. Materials with higher water-absorbing ability than matrix are applied to control the water and salt migration direction in simulated sand samples. The distribution of moisture content on the surface of sand is followed by hyperspectral imaging. It appears that water and salt molecules will preferentially transport towards positions containing higher water-absorbing material. Both organic and inorganic high water-absorbing materials show effective in controlling the water and salt migration direction, which provides a new approach for the prevention and protection of salt efflorescence in silicate cultural relics.