bluuebunny/crossref_metadata_2025_split huggingface dataset:
Spatiotemporal patterns of throwing muscle synergies in yips-affected baseball players
Authors: Aoyama Toshiyuki , Ae Kazumichi , Taguchi Takahiro , Kawamori Yuna , Sasaki Daisuke , Kawamura Takashi , Kohno Yutaka 
Published: February 2024

Abstract“Yips” are involuntary movements that interfere with the automatic execution of sports movements. However, how the coordination among the various muscles necessary for sports movements is impaired in athletes with yips remains to be fully understood. This study aimed to assess whether muscle synergy analysis through non-negative matrix factorization (NMF) could identify impaired spatiotemporal muscle coordination in baseball players with throwing yips. Twenty-two college baseball players, including 12 with and 10 without yips symptoms participated in the study. Electromyographic activity was recorded from 13 ipsilateral upper extremity muscles during full-effort throwing. Muscle synergies were extracted through NMF. Cluster analysis was conducted to identify any common spatiotemporal patterns of muscle synergies in players with yips. Whether individual players with yips showed deviations in spatiotemporal patterns of muscle synergies compared with control players was also investigated. Four muscle synergies were extracted for each player, but none were specific to the yips group. However, a more detailed analysis of individual players revealed that two of the three players who presented dystonic symptoms during the experiment exhibited specific patterns that differed from those in control players. By contrast, each player whose symptoms were not reproduced during the experiment presented spatiotemporal patterns of muscle synergies similar to those of the control group. The results of this study indicate no common spatiotemporal pattern of muscle synergies specific to the yips group. Furthermore, these results suggest that the spatiotemporal pattern of muscle synergies in baseball throwing motion is not impaired in situations where symptoms are not reproduced even if the players have yips symptoms. However, muscle synergy analysis can identify the characteristics of muscle coordination of players who exhibit dystonic movements. These findings can be useful in developing personalized therapeutic strategies based on individual characteristics of yips symptoms.
Leptin haploinsufficiency exerts sex-dependent partial protection in SOD1G93A mice by reducing inflammatory pathways in the adipose tissue
Authors: Fernández-Beltrán Luis C. , Ali Zeinab , Larrad-Sanz Angélica , Lopez-Carbonero Juan I. , Godoy-Corchuelo Juan M. , Jimenez-Coca Irene , Garcia-Toledo Irene , Bentley Liz , Gomez-Pinedo Ulises , Matias-Guiu Jordi A. , Gil-Moreno Maria Jose , Matias-Guiu Jorge , Corrochano Silvia 
Published: February 2024

AbstractAmyotrophic lateral sclerosis (ALS) is a fatal neurodegenerative disorder characterized by significant metabolic disruptions, including weight loss and hypermetabolism in both patients and animal models. Leptin, an adipose-derived hormone, displays altered levels in ALS. Genetically reducing leptin levels (Lepob/+) to maintain body weight improved motor performance and extended survival in female SOD1G93A mice, although the exact molecular mechanisms behind these effects remain elusive. Here, we corroborated the sexual dimorphism in circulating leptin levels in ALS patients and in SOD1G93A mice. We reproduced a previous strategy to generate a genetically deficient leptin SOD1G93A mice (SOD1G93ALepob/+) and studied the transcriptomic profile in the subcutaneous adipose tissue and the spinal cord. We found that leptin deficiency reduced the inflammation pathways activated by the SOD1G93A mutation in the adipose tissue, but not in the spinal cord. These findings emphasize the importance of considering sex-specific approaches in metabolic therapies and highlight the role of leptin in the systemic modulation of ALS by regulating immune responses outside the central nervous system.
A comparative study on vildagliptin brand and its generic equivalents using dissolution test as quality control measure tool
Authors: Altoum Ghadah H. , AL-Enazi Fouza K. , Abudahash Mubarl M. , AL-Fadhli Reem A. , Alenzi Naif 
Published: February 2024

AbstractMarket drugs including brand or generic with poor quality, don’t meet the acceptable standard guidelines. Vildagliptin is an important antidiabetic drugs used in monotherapy or in combinations protocols for treatment of diabetes mellites. The main goal of the current study is to assess the pharmaceutical equivalence of two marketed generics of vildagliptin 50 mg tablets compared to the branded product (Galvus 50 mg). The in vitro dissolution test was used as a quality control tool to obtain the dissolution profile of vildagliptin compared to the reference drug. The results revealed that all tested samples showed dissolution behavior like standard drug. Whole samples dissolution reached after 15 min in accordance with the standard. According to the similarity factors records, tested vildagliptin samples showed a comparable dissolution to the reference drug. The current work presents an in vitro protocol for quality evaluation of recently released generic drugs.
Enhancing particle focusing: a comparative experimental study of modified square wave and square wave microchannels in lift and Dean vortex regimes
Authors: Ashkani Ali , Jafari Azadeh , Ghomsheh Mehryar Jannesari , Dumas Norbert , Funfschilling Denis 
Published: February 2024

AbstractSerpentine microchannels are known for their effective particle focusing through Dean flow-induced rotational effects, which are used in compact designs for size-dependent focusing in medical diagnostics. This study explores square serpentine microchannels, a geometry that has recently gained prominence in inertial microfluidics, and presents a modification of square wave microchannels for improved particle separation and focusing. The proposed modification incorporates an additional U-shaped unit to convert the square wave microchannel into a non-axisymmetric structure, which enhances the Dean flow and consequently increases the Dean drag force. Extensive experiments were conducted covering a wide range of Reynolds numbers and particle sizes (2.45 µm to 12 µm). The particle concentration capability and streak position dynamics of the two structures were compared in detail. The results indicate that the modified square-wave microchannel exhibits efficient particle separation in the lower part of the Dean vortex-dominated regime. With increasing Reynolds number, the particles are successively focused into two streaks in the lift force-dominated regime and into a single streak in the Dean vortex-dominated regime, in this modified square wave geometry. These streaks have a low standard deviation around a mean value. In the Dean vortex-dominated regime, the location of the particle stream is highly dependent on the particle size, which allows good particle separation. Particle focusing occurs at lower Reynolds numbers in both the lift-dominated and lift/Dean drag-dominated regions than in the square wave microchannel. The innovative serpentine channel is particularly useful for the Dean drag-dominated regime and introduces a unique asymmetry that affects the particle focusing dynamics. The proposed device offers significant advantages in terms of efficiency, parallelization, footprint, and throughput over existing geometries.
Global burden and risk factors of gastritis and duodenitis: an observational trend study from 1990 to 2019
Authors: Liu Yupei , Zhang Jixiang , Guo Yingyun , Tian Shan , Wu Yanrui , Liu Chuan , Huang Xiaoyu , Zhang Shufei , Dong Weiguo 
Published: February 2024

AbstractIn recent years, there has been a global trend of aging, which has resulted in significant changes to the burden of gastritis and duodenitis (GD). Using the global burden of disease (GBD) database spanning 1990 to 2019, we evaluated the temporal trends of age-standardized incidence rates (ASIR), age-standardized death rates (ASDR), and age-standardized disability-adjusted life years (AS-DALYs) for GD using estimated annual percentage changes (EAPC). Additionally, we examined the burden of GD across various strata, including social demographic index (SDI), age, and sex. Finally, the risk factors linked to the incidence and mortality of GD, utilizing Pearson correlation analysis. In 2019, there were 31 million GD patients globally, a notable increase of 12 million from 1990, while the ASIR, ASDR, and AS-DALYs for GD all showed a decrease. Correlation analysis showed a significant negative relationship between ASIR and SDI. Factors like hand hygiene and vitamin A deficiency had significant positive correlations with ASIR and ASDR in 2019. Over the past thirty years, the burden of GD has increased alongside global population aging. Future efforts should focus on exploring prevention for GD, with special attention to the elderly population in low SDI regions.
Modulating the skin mycobiome-bacteriome and treating seborrheic dermatitis with a probiotic-enriched oily suspension
Authors: Truglio Mauro , Sivori Francesca , Cavallo Ilaria , Abril Elva , Licursi Valerio , Fabrizio Giorgia , Cardinali Giorgia , Pignatti Marco , Toma Luigi , Valensise Floriana , Cristaudo Antonio , Pimpinelli Fulvia , Di Domenico Enea Gino 
Published: February 2024

AbstractSeborrheic dermatitis (SD) affects 2–5% of the global population, with imbalances in the skin microbiome implicated in its development. This study assessed the impact of an oily suspension containing Lactobacillus crispatus P17631 and Lacticaseibacillus paracasei I1688 (termed EUTOPLAC) on SD symptoms and the skin mycobiome-bacteriome modulation. 25 SD patients were treated with EUTOPLAC for a week. Symptom severity and skin mycobiome-bacteriome changes were measured at the start of the treatment (T0), after seven days (T8), and three weeks post-treatment (T28). Results indicated symptom improvement post-EUTOPLAC, with notable reductions in the Malassezia genus. Concurrently, bacterial shifts were observed, including a decrease in Staphylococcus and an increase in Lactobacillus and Lacticaseibacillus. Network analysis highlighted post-EUTOPLAC instability in fungal and bacterial interactions, with increased negative correlations between Malassezia and Lactobacillus and Lacticaseibacillus genera. The study suggests EUTOPLAC's potential as a targeted SD treatment, reducing symptoms and modulating the mycobiome-bacteriome composition.
Evaluation of three protocols for direct susceptibility testing for gram negative-Enterobacteriaceae from patient samples in Uganda with SMS reporting
Authors: Aruhomukama Dickson , Magiidu Walusimbi Talemwa , Katende George , Ebwongu Robert Innocent , Bulafu Douglas , Kasolo Rajab , Nakabuye Hellen , Musoke David , Asiimwe Benon 
Published: February 2024

AbstractIn Uganda, the challenge of generating and timely reporting essential antimicrobial resistance (AMR) data has led to overreliance on empirical antibiotic therapy, exacerbating the AMR crisis. To address this issue, this study aimed to adapt a one-step AMR testing protocol alongside an SMS (Short Message Service) result relay system (SRRS), with the potential to reduce the turnaround time for AMR testing and result communication from 4 days or more to 1 day in Ugandan clinical microbiology laboratories. Out of the 377 samples examined, 54 isolates were obtained. Notably, E. coli (61%) and K. pneumoniae (33%) were the most frequently identified, majority testing positive for ESBL. Evaluation of three AMR testing protocols revealed varying sensitivity and specificity, with Protocol A (ChromID ESBL-based) demonstrating high sensitivity (100%) but no calculable specificity, Protocol B (ceftazidime-based) showing high sensitivity (100%) and relatively low specificity (7.1%), and Protocol C (cefotaxime-based) exhibiting high sensitivity (97.8%) but no calculable specificity. ESBL positivity strongly correlated with resistance to specific antibiotics, including cefotaxime, ampicillin, and aztreonam (100%), cefuroxime (96%), ceftriaxone (93%), and trimethoprim sulfamethoxazole (87%). The potential of integrating an SRRS underscored the crucial role this could have in enabling efficient healthcare communication in AMR management. This study underscores the substantial potential of the tested protocols for accurately detecting ESBL production in clinical samples, potentially, providing a critical foundation for predicting and reporting AMR patterns. Although considerations related to specificity warrant careful assessment before widespread clinical adoption.
Manipulating objects during learning shrinks the global scale of spatial representations in memory: a virtual reality study
Authors: Lhuillier S. , Dutriaux L. , Nicolas S. , Gyselinck V. 
Published: February 2024

AbstractGoal-directed approaches to perception usually consider that distance perception is shaped by the body and its potential for interaction. Although this phenomenon has been extensively investigated in the field of perception, little is known about the effect of motor interactions on memory, and how they shape the global representation of large-scale spaces. To investigate this question, we designed an immersive virtual reality environment in which participants had to learn the positions of several items. Half of the participants had to physically (but virtually) grab the items with their hand and drop them at specified locations (active condition). The other half of the participants were simply shown the items which appeared at the specified position without interacting with them (passive condition). Half of the items used during learning were images of manipulable objects, and the other half were non manipulable objects. Participants were subsequently asked to draw a map of the virtual environment from memory, and to position all the items in it. Results show that active participants recalled the global shape of the spatial layout less precisely, and made more absolute distance errors than passive participants. Moreover, global scaling compression bias was higher for active participants than for passive participants. Interestingly, manipulable items showed a greater compression bias compared to non-manipulable items, yet they had no effect on correlation scores and absolute non-directional distance errors. These results are discussed according to grounded approaches of spatial cognition, emphasizing motor simulation as a possible mechanism for position retrieval from memory.
Extensive lymphadenectomy may improve survival in node negative oesophageal cancer
Authors: Khoma Oleksandr , Paredes Steven R. , Park Jin-soo , Kennedy Catherine W. , Falk Gregory L. 
Published: February 2024

AbstractLymph node metastases are a major prognostic factor in survival of patients with oesophageal cancer. The number of lymph nodes removed during oesophagectomy has been previously proven to be associated with improved survival. The aim of this study was to examine the effect of lymph node harvest on survival specifically in pathologically node negative (pN0) patients with oesophageal cancer. Data were extracted from a prospectively populated single-surgeon database of oesophageal resections for cancer. All consecutive patients with pN0 were included. Patient-specific risk adjusted analysis of overall and disease-free survival was performed to identify the number of lymph nodes associated with improved survival. Inclusion criteria were met by 137 patients (49 squamous cell carcinoma and 88 adenocarcinoma). Adjusted for cancer stage, tumour (histological type, degree of differentiation, lympho-vascular invasion, neo-adjuvant therapy) and patient related factors (age, sex), increased lymph node number was associated with significant improvement in overall (P = 0.045) and disease free (P = 0.030) survival. Lymph node count ≥ 17 was associated with improved overall and disease-free survival. In this cohort of patients with pathologically node-negative oesophageal cancer, lymph node count of 17 or above was associated with significantly improved survival.
Macroscale intrinsic dynamics are associated with microcircuit function in focal and generalized epilepsies
Authors: Yang Siqi , Zhou Yimin , Peng Chengzong , Meng Yao , Chen Huafu , Zhang Shaoshi , Kong Xiaolu , Kong Ru , Yeo B. T. Thomas , Liao Wei , Zhang Zhiqiang 
Published: February 2024

AbstractEpilepsies are a group of neurological disorders characterized by abnormal spontaneous brain activity, involving multiscale changes in brain functional organizations. However, it is not clear to what extent the epilepsy-related perturbations of spontaneous brain activity affect macroscale intrinsic dynamics and microcircuit organizations, that supports their pathological relevance. We collect a sample of patients with temporal lobe epilepsy (TLE) and genetic generalized epilepsy with tonic-clonic seizure (GTCS), as well as healthy controls. We extract massive temporal features of fMRI BOLD time-series to characterize macroscale intrinsic dynamics, and simulate microcircuit neuronal dynamics used a large-scale biological model. Here we show whether macroscale intrinsic dynamics and microcircuit dysfunction are differed in epilepsies, and how these changes are linked. Differences in macroscale gradient of time-series features are prominent in the primary network and default mode network in TLE and GTCS. Biophysical simulations indicate reduced recurrent connection within somatomotor microcircuits in both subtypes, and even more reduced in GTCS. We further demonstrate strong spatial correlations between differences in the gradient of macroscale intrinsic dynamics and microcircuit dysfunction in epilepsies. These results emphasize the impact of abnormal neuronal activity on primary network and high-order networks, suggesting a systematic abnormality of brain hierarchical organization.
Integrated design and construction of the NiMoS4@Co9S8/Ni3S2 hollow core–shell heterostructure for high-performance asymmetric supercapacitors
Authors: Yu Gaigai , Wu Lei , Huang Shijie , Zhao Wenna , Han Lei 
Published: February 2024

A multi-component NiMoS4@Co9S8/Ni3S2 heterostructure with hollow core–shell morphology exhibits excellent electrochemical performances for asymmetric supercapacitor.
Immune receptors and aging brain
Authors: Djurišić Maja 
Published: February 2024

Abstract
Aging brings about a myriad of degenerative processes throughout the body. A decrease in cognitive abilities is one of the hallmark phenotypes of aging, underpinned by neuroinflammation and neurodegeneration occurring in the brain. This review focuses on the role of different immune receptors expressed in cells of the central and peripheral nervous systems. We will discuss how immune receptors in the brain act as sentinels and effectors of the age-dependent shift in ligand composition. Within this ‘old-age-ligand soup,’ some immune receptors contribute directly to excessive synaptic weakening from within the neuronal compartment, while others amplify the damaging inflammatory environment in the brain. Ultimately, chronic inflammation sets up a positive feedback loop that increases the impact of immune ligand–receptor interactions in the brain, leading to permanent synaptic and neuronal loss.
NaHCO3 loading causes increased arterial pressure and kidney damage in rats with chronic kidney disease
Authors: Mannon Elinor C. , Muller P. Robinson , Sun Jingping , Bush Weston B. , Coleman Alex , Ocasio Hiram , Polichnowski Aaron J. , Brands Michael W. , O'Connor Paul M. 
Published: February 2024

Abstract
Sodium bicarbonate (NaHCO3) is commonly utilized as a therapeutic to treat metabolic acidosis in people with chronic kidney disease (CKD). While increased dietary sodium chloride (NaCl) is known to promote volume retention and increase blood pressure, the effects of NaHCO3 loading on blood pressure and volume retention in CKD remain unclear. In the present study, we compared the effects of NaCl and NaHCO3 loading on volume retention, blood pressure, and kidney injury in both 2/3 and 5/6 nephrectomy remnant kidney rats, a well-established rodent model of CKD. We tested the hypothesis that NaCl loading promotes greater volume retention and increases in blood pressure than equimolar NaHCO3. Blood pressure was measured 24 h daily using radio telemetry. NaCl and NaHCO3 were administered in drinking water ad libitum or infused via indwelling catheters. Rats were housed in metabolic cages to determine volume retention. Our data indicate that both NaHCO3 and NaCl promote hypertension and volume retention in remnant kidney rats, with salt-sensitivity increasing with greater renal mass reduction. Importantly, while NaHCO3 intake was less pro-hypertensive than equimolar NaCl intake, NaHCO3 was not benign. NaHCO3 loading significantly elevated blood pressure and promoted volume retention in rats with CKD when compared with control rats receiving tap water. Our findings provide important insight into the effects of sodium loading with NaHCO3 in CKD and indicate that NaHCO3 loading in patients with CKD is unlikely to be benign.
Complémentarité de l’odontologie et de l’anthropologie pour l’identification de corps sous « X »
Authors: Bou Christophe 
Published: February 2024

La presse se fait régulièrement l’écho de disparitions inquiétantes d’enfants ou d’adultes, de suicidés, de victimes d’accidents, de sans-abri, et de la découverte souvent fortuite de corps ou de restes humains, avec ou sans présomption d’identité. En 2011, une étude rétrospective réalisée sur six ans au sein de l’institut médico-légal (IML) de l’hôpital Poincaré à Garches, énonçait le chiffre surprenant de plus de 1 500 inhumations sous X par an en France. Véritable constat d’échec, c’est tout un ensemble de dysfonctionnements qui sont à l’origine de cette situation. À travers cet article, nous tentons d’en identifier les causes et de voir comment l’identification en odontologie et anthropologie pourraient contribuer à résoudre cette problématique, véritable enjeu de santé publique.
Approche biomimétique des restaurations des tissus dentaires
Authors: Colon Pierre , Grosgogeat Brigitte 
Published: February 2024

Les dents constituent un organe particulier. Elles permettent la fonction masticatrice, participent à la phonation et ont un rôle important dans les relations sociales. Elles doivent résister à des variations de température, comprises entre 5 °C et 55 °C, aux contraintes mécaniques de la mastication, et aux acides présents dans l’alimentation.
Unveiling Gambogenic Acid as a Promising Antitumor Compound: A Review
Authors: Mi Li , Xing Zhichao , Zhang Yujie , He Ting , Su Anping , Wei Tao , Li Zhihui , Wu Wenshuang 
Published: February 2024

AbstractGambogenic acid is a derivative of gambogic acid, a polyprenylated xanthone isolated from Garcinia hanburyi. Compared with the more widely studied gambogic acid, gambogenic acid has demonstrated advantages such as a more potent antitumor effect and less systemic toxicity than gambogic acid according to early investigations. Therefore, the present review summarizes the effectiveness and mechanisms of gambogenic acid in different cancers and highlights the mechanisms of action. In addition, drug delivery systems to improve the bioavailability of gambogenic acid and its pharmacokinetic profile are included. Gambogenic acid has been applied to treat a wide range of cancers, such as lung, liver, colorectal, breast, gastric, bladder, and prostate cancers. Gambogenic acid exerts its antitumor effects as a novel class of enhancer of zeste homolog 2 inhibitors. It prevents cancer cell proliferation by inducing apoptosis, ferroptosis, and necroptosis and controlling the cell
cycle as well as autophagy. Gambogenic acid also hinders tumor cell invasion and metastasis by downregulating metastasis-related proteins. Moreover, gambogenic acid increases the sensitivity of cancer cells to chemotherapy and has shown effects on multidrug resistance in malignancy. This review adds insights for the prevention and treatment of cancers using gambogenic acid.