bluuebunny/crossref_metadata_2025_split huggingface dataset:
Generative adversarial network as a basis for intelligent model of imaging architectural objects based on textual description (Kemerovo, Tomsk)
Authors: Pylov P. A. , Dyagileva A. V. , Nikolaeva E. A. , Maitak R. V. , Shalygina T. A. 
Published: October 2023

Вывод: рассматриваемая автоматизирующая система позволит существенно сократить временные, человеческие и денежные ресурсы, требуемые для разработки проекта будущего здания.Перенести в английский вариант Due to the high technology integrated into a person's daily life (smart house), this topic is relevant. One of elements of generative adversarial network is robot vacuum cleaners of various surface. Difficulties caused by this technique largely depend on the environment in which it locates. Purpose: The development of the convolutional neural network concept allowing real-time distinguishing between the building interior and exterior. Practical implication: The proposed intelligent system can distinguish between the building interior and exterior, that will considerably improve the firmware performance of modern technology in both the domestic and industrial segments.
Stoics and Epicureans on Facing Pain and Death Positively
Authors: O'Reilly Katharine , Gill Chris 
Published: October 2023

<p>This post is based on a joint workshop we offered at the Stoicon-X in London on October 13 2019, on ideas about facing pain and death offered by the ancient Stoics and their main contemporary rivals, the Epicureans. The core idea shared by both these theories is that, if you achieve wisdom, you will be well-placed to deal with things generally regarded as among the worst dimensions of human life – enduring extreme physical pain and facing the prospect of your own death. Katharine focused on a letter supposedly written by Epicurus shortly before his death and at a time of intense physical pain. Chris discussed the Stoic version of a well-known ancient philosophical ideal, that of the wise person happy on the rack of torture. We give here the text of these talks, which were followed by a vigorous debate on these ideas and their value as a basis for life-guidance under modern conditions. </p>
‘I will play this tokenistic game, I just want something useful for my community’: experiences of and resistance to harms of peer research
Authors: E. Ross Lori , Pilling Merrick , Voronka Jijian , Pitt Kendra-Ann , McLean Elizabeth , King Carole , Shakya Yogendra M. , MacKinnon Kinnon R. , Williams Charmaine C. , Strike Carol , Guta Adrian 
Published: October 2023

<p>Hiring peer researchers – individuals with lived experience of the phenomenon under study – is an increasingly popular practice. However, little research has examined experiences of peer research from the perspectives of peer researchers themselves. In this paper, we report on data from a participatory, qualitative research project focused on four intersecting communities often engaged in peer research: mental health service user/consumer/survivor; people who use drugs; racialized; and trans/non-binary communities. In total, 34 individuals who had worked as peer researchers participated in semi-structured interviews. Transcripts and interviewer reflections were analyzed using a participatory approach. Many participants reported exposure to intersecting forms of systemic oppression (racism, transphobia, ableism, and classism, among others) and disparagement of their identities and lived experiences, both from other members of the research team and from the broader institutions in which they were working. Peer researchers described being required to perform academic professionalism, while simultaneously representing communities that were explicitly or implicitly denigrated in the course of their work. Practices of resistance to these harms were evident throughout the interviews, and participants often made strategic decisions to permit themselves to be tokenized, out of the expectation of promised benefits to their communities. However, additional harms were often experienced when these benefits were not realized. These findings point towards the need for a more reflexive and critical approach to the use of peer research.</p>
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FAKTOR-FAKTOR YANG MEMPENGARUHI AUDIT DELAY PADA PERUSAHAAN JASA LISTED BEI
Authors: Diana Dwi Astuti  , Ningsih Wiwik Fitria 
Published: October 2023

Waktu penyelesaian audit oleh auditor yang memiliki reputasi baik cenderung lebih pendek sehingga reputasi KAP berpengaruh terhadap audit delay. Tujuan dalam penelitian ini yaitu untuk menganalisis pengaruh Ukuran Perusahaan, Kompleksitas operasi perusahaan, reputasi kantor akuntan publik dan opini Auditor secara parsial terhadap audit delay.; Untuk menganalisis pengaruh ukuran perusahaan, kompleksitas operasi perusahaan, reputasi kantor akuntan publik dan opini auditor secara simultan terhadap audit delay. Penelitian ini menunjukan bahwa sebaiknya perusahaan dalam menghindari resiko audit delay memperhatikan ukuran perusahaan karena dapat mempengaruhi manajemen untuk lama atau tidaknya proses pengerjaan laporan keuangan. Dengan ukuran perusahaan semakin besar yang dilihat dari indikator total aktiva, jumlah penjualan dan nilai saham, maka perusahaan tersebut akan lebih baik dalam pengerjaan laporan keuangan sehingga saat pengauditan lebih cepat dan resiko audit delay akan tehindar sebaliknya jika ukuran perusahaan tidak besar akan memperlambat proses pengerjaan laporan keuangan yang akan mengakibatkan resiko audit delay.
Kata Kunci: Pemeriksaan, Akuntan Publik, Opini, Audit delay
The audit completion time by an auditor who has a good reputation tends to be shorter so that the KAP reputation affects audit delay. The purpose of this study is to analyze the effect of company size, complexity of company operations, reputation of public accounting firm and auditor's opinion partially on audit delay; To analyze the effect of firm size, complexity of company operations, reputation of public accounting firm and auditor's opinion simultaneously on audit delay. This research shows that the company should avoid the risk of audit delay by paying attention to the size of the company because it can affect the management for the length of the process of working on the financial statements. With the size of the company getting bigger as seen from the indicators of total assets, total sales and value of shares, then the company will be better at working on financial statements so that when auditing is faster and the risk of audit delay will be avoided, otherwise if the size of the company is not large it will slow down the report processing process. which will result in the risk of audit delay.
Keywords: Public Accountant, Opinion, Audit Delay
SARS-CoV-2 pre-exposure prophylaxis with tixagevimab/cilgavimab (AZD7442) provides protection in inborn errors of immunity with antibody defects: a real-world experience
Authors: Pulvirenti Federica , Garzi Giulia , Milito Cinzia , Sculco Eleonora , Sciannamea Maddalena , Napoli Anna , Cinti Lilia , Roberto Piergiorgio , Punziano Alessandra , Carrabba Maria , Piano Mortari Eva , Carsetti Rita , Antonelli Guido , Quinti Isabella 
Published: October 2023

BackgroundPreventive strategies against severe COVID-19 in Inborn Errors of Immunity (IEI) include bivalent vaccines, treatment with SARS-CoV-2 monoclonal antibodies (mAbs), early antiviral therapies, and pre-exposure prophylaxis (PrEP).ObjectiveTo assess the effectiveness of the PrEP with tixagevimab/cilgavimab (AZD7442) in IEI with primary antibody defects during the COVID-19 Omicron wave.MethodsA six-month prospective study evaluated the SARS-CoV-2 infection rate and the COVID-19 severity in the AZD7442 group, in the no-AZD7442 group, and in a group of patients with a recent SARS-CoV-2 infection (&lt; three months). Spike-specific IgG levels were measured at regular intervals.ResultsSix out of thirty-three patients (18%) and 54/170 patients (32%) became infected in the AZD7442 group and in the no-AZD7442 group, respectively. Within 90 days post-administration, the AZD7442 group was 85% less likely to be infected and 82% less likely to have a symptomatic disease than the no-AZD7442 group. This effect was lost thereafter. In the entire cohort, no mortality/hospitalisation was observed. The control group of 35 recently infected patients was 88% and 92% less likely to be infected than the AZD7442 and no-AZD7442 groups. Serum anti-Spike IgG reached the highest peak seven days post-AZD7442 PrEP then decreased, remaining over 1000 BAU/mL 180 days thereafter.ConclusionIn patients with IEI and antibody defects, AZD7442 prophylaxis had a transient protective effect, possibly lost possibly because of the appearance of new variants. However, PrEP with newer mAbs might still represent a feasible preventive strategy in the future in this population.
Glycosylation of bacterial antigens changes epitope patterns
Authors: Kern Karolin , Delaroque Nicolas , Boysen Anders , Puder Marcus , Wendt Ralph , Kölsch Andreas , Ehrentreich-Förster Eva , Stærk Kristian , Andersen Thomas Emil , Andersen Karin , Lund Lars , Szardenings Michael 
Published: October 2023

IntroductionUnlike glycosylation of proteins expressed in mammalian systems, bacterial glycosylation is often neglected in the development of recombinant vaccines.MethodsHere, we compared the effects of glycosylation of YghJ, an Escherichia coli protein important for mucus attachment of bacteria causing in urinary tract infections (UTIs). A novel method based on statistical evaluation of phage display for the identification and comparison of epitopes and mimotopes of anti-YghJ antibodies in the sera was used. This is the first time that the effect of glycosylation of a recombinant bacterial antigen has been studied at the peptide epitope level.ResultsThe study identifies differences in the immune response for (non)-glycosylated antigens in rabbits and pigs and compares them to a large group of patients with UTI, which have been diagnosed as positive for various bacterial pathogens. We identified glycosylation-specific peptide epitopes, a large immunological similarity between different UTI pathogens, and a broad peptide epitope pattern in patients and animals, which could result in a variable response in patients upon vaccination.DiscussionThis epitope analysis indicates that the vaccination of rabbits and pigs raises antibodies that translate well into the human immune system. This study underlines the importance of glycosylation in bacterial vaccines and provides detailed immune diagnostic methods to understand individual immune responses to vaccines.
Differences of airborne and mural microorganisms in a 1,500-year-old Xu Xianxiu’s Tomb, Taiyuan, China
Authors: Liu Jiangyun , Wu Fasi , Xiang Ting , Ma Wenxia , He Dongpeng , Zhang Qi , Wang Wanfu , Duan Yulong , Tian Tian , Feng Huyuan 
Published: October 2023

BackgroundMicrobial colonization represents one of the main threats to the conservation of subterranean cultural heritage sites. Recently, the microbial colonization on murals in tombs has gradually attracted attention.MethodsIn this study, a total of 33 samples, including 27 aerosol samples and 6 mural painting samples, were collected from different sites of Xu Xianxiu’s Tomb and analyzed using culture-dependent methods. We compared the diversities of culturable bacteria and fungi isolated from the air and murals and explored the potential impacts of microorganisms on the biodeterioration of the murals.ResultsPhylogenetic analyses revealed that the culturable bacteria belonged to Bacillus, Microbacterium, Lysobacter and Arthrobacter. And the most of fungal belonged to the Penicillium, Cladosporium and Aspergillus genera. The composition and structure of airborne bacteria and fungi outside the tomb were both significantly different from that inside the tomb. The variation trends of airborne bacterial and fungal concentrations at different sampling sites were remarkably similar. Bacillus frigoritolerans, Bacillus halotolerans, Bacillus safensis, Exiguobacterium mexicanum, Microbacterium trichothecenolyticum, and Micrococcus yunnanensis were bacterial species commonly isolated from both the mural and air environments. Fungal species commonly isolated from aerosol samples and mural painting samples were Alternaria alternata, Cladosporium cladosporioides, Penicillium brevicompactum, and Peyronellaea glomerata. The prediction of the ecological functions of the bacteria revealed that chemoheterotrophy or aerobic_chemoheterotrophy accounted for substantial relative proportions in all sample types.ConclusionThese results suggest that the aerosol circulation between the inside and outside environments of the tomb was weak and that the outside environment had yet to have an impact on the air microbial community inside the tomb. Selective colonization of microorganisms, which is mediated by interaction between microorganisms and special microenvironmental factors, is an important reason for the biodeterioration of murals.
Cognitive impairment in long-living adults: a genome-wide association study, polygenic risk score model and molecular modeling of the APOE protein
Authors: Kashtanova D. A. , Mamchur A. A. , Dzhumaniyazova I. H. , Ivanov M. V. , Erema V. V. , Zelenova E. A. , Yakovchik A. Y. , Gusakova M. S. , Rumyantseva A. M. , Terekhov M. V. , Matkava L. R. , Akopyan A. A. , Strazhesko I. D. , Yudin V. S. , Makarov V. V. , Kraevoy S. A. , Tkacheva O. N. , Yudin S. M. 
Published: October 2023

BackgroundCognitive impairment is an irreversible, aging-associated condition that robs people of their independence. The purpose of this study was to investigate possible causes of this condition and propose preventive options.MethodsWe assessed cognitive status in long-living adults aged 90+ (n = 2,559) and performed a genome wide association study using two sets of variables: Mini-Mental State Examination scores as a continuous variable (linear regression) and cognitive status as a binary variable (&gt; 24, no cognitive impairment; &lt;10, impairment) (logistic regression).ResultsBoth variations yielded the same polymorphisms, including a well-known marker of dementia, rs429358in the APOE gene. Molecular dynamics simulations showed that this polymorphism leads to changes in the structure of alpha helices and the mobility of the lipid-binding domain in the APOE protein.ConclusionThese changes, along with higher LDL and total cholesterol levels, could be the mechanism underlying the development of cognitive impairment in older adults. However, this polymorphism is not the only determining factor in cognitive impairment. The polygenic risk score model included 45 polymorphisms (ROC AUC 69%), further confirming the multifactorial nature of this condition. Our findings, particularly the results of PRS modeling, could contribute to the development of early detection strategies for predisposition to cognitive impairment in older adults.
Case report: First treatment of acute ischaemic stroke in a patient on active rivaroxaban therapy using andexanet alfa and rtPA combined with early complete recovery
Authors: Karaszewski Bartosz , Szczyrba Sebastian , Jabłoński Bartosz , Gąsecki Dariusz , Kraszewski Piotr , Wyszomirski Adam , Kowalski Robert , Kaliszan Wioletta , Dąbrowska Małgorzata 
Published: October 2023

Patients with non-large vessel occlusion acute ischemic stroke (NL-AIS) on oral anticoagulants (OAC) constitute the biggest portion among those who cannot receive any potential-reperfusion treatment even if they appear early in the hospital. We present the first case of therapy for NL-AIS in a patient with active anti-Xa anticoagulation, combining andexanet alfa and rtPA, who was recruited for STRoke On AntiCoagulants for Thrombolysis (acronym: STROACT), an ongoing therapeutic trial for non-LVO ischemic stroke on a DOAC. This is also the first report of the use of andexanet alfa-rtPA for AIS in a patient on rivaroxaban, which is the most frequently used non-vitamin K antagonist oral anticoagulant. The patient received the intravenous bolus of 800 mg of andexanet (contralateral arm), followed by a bolus of rtPA (10% of the calculated dose; ipsilateral arm), then a continuous infusion of andexanet at 8 mg/min for 120 min (contralateral arm), and rtPA (90% of the calculated dose; ipsilateral arm)—both stopped after completion of 38.9 and 74% of infusion dose, respectively, due to the severe adverse event related to the administration of rtPA. In this schema, both infusions are ongoing concurrently for approximately 60 min, and then andexanet is administered alone until the completion of the dose (altogether lasting approximately 3 h). The therapy was spectacularly effective, with early and complete improvement in NIHSS from 8 to 0 points in 70 min from the initiation of the therapy; mRS = 0. Obviously, a single case cannot drive any standard therapeutic decisions, but the experience we share in this article may help manage selected special clinical problems, especially when a patient's expected outcome is poor and there is no other way to help than experimentally. Additionally, it seems a valuable addition to recent meta-data on thrombolysis in anticoagulated patients.Trial registrationhttps://www.clinicaltrialsregister.eu. Identifier: 2020-004898-41. Date of registration: March 31, 2021.
Automatic planning of MR-guided transcranial focused ultrasound treatment for essential tremor
Authors: Klein Jan , Gerken Annika , Agethen Niklas , Rothlübbers Sven , Upadhyay Neeraj , Purrer Veronika , Schmeel Carsten , Borger Valeri , Kovalevsky Maya , Rachmilevitch Itay , Shapira Yeruham , Wüllner Ullrich , Jenne Jürgen 
Published: October 2023

IntroductionTranscranial focused ultrasound therapy (tcFUS) offers precise thermal ablation for treating Parkinson's disease and essential tremor. However, the manual fine-tuning of fiber tracking and segmentation required for accurate treatment planning is time-consuming and demands expert knowledge of complex neuroimaging tools. This raises the question of whether a fully automated pipeline is feasible or if manual intervention remains necessary.MethodsWe investigate the dependence on fiber tractography algorithms, segmentation approaches, and degrees of automation, specifically for essential tremor therapy planning. For that purpose, we compare an automatic pipeline with a manual approach that requires the manual definition of the target point and is based on FMRIB software library (FSL) and other open-source tools.ResultsOur findings demonstrate the high feasibility of automatic fiber tracking and the automated determination of standard treatment coordinates. Employing an automatic fiber tracking approach and deep learning (DL)–supported standard coordinate calculation, we achieve anatomically meaningful results comparable to a manually performed FSL-based pipeline. Individual cases may still exhibit variations, often stemming from differences in region of interest (ROI) segmentation. Notably, the DL-based approach outperforms registration-based methods in producing accurate segmentations. Precise ROI segmentation proves crucial, surpassing the importance of fine-tuning parameters or selecting algorithms. Correct thalamus and red nucleus segmentation play vital roles in ensuring accurate pathway computation.ConclusionThis study highlights the potential for automation in fiber tracking algorithms for tcFUS therapy, but acknowledges the ongoing need for expert verification and integration of anatomical expertise in treatment planning.
Sensation seeking correlates with increased white matter integrity of structures associated with visuospatial processing in healthy adults
Authors: Escelsior Andrea , Inuggi Alberto , Amadeo Maria Bianca , Engel-Yeger Batya , Trabucco Alice , Esposito Davide , Campus Claudio , Bovio Anna , Comparini Sara , Pereira da Silva Beatriz , Serafini Gianluca , Gori Monica , Amore Mario 
Published: October 2023

IntroductionThe ability to process sensory information is an essential adaptive function, and hyper- or hypo-sensitive maladaptive profiles of responses to environmental stimuli generate sensory processing disorders linked to cognitive, affective, and behavioral alterations. Consequently, assessing sensory processing profiles might help research the vulnerability and resilience to mental disorders. The research on neuroradiological correlates of the sensory processing profiles is mainly limited to the young-age population or neurodevelopmental disorders. So, this study aims to examine the structural MRI correlates of sensory profiles in a sample of typically developed adults.MethodsWe investigated structural cortical thickness (CT) and white matter integrity, through Diffusion Tensor Imaging (DTI), correlates of Adolescent/Adult Sensory Profile (AASP) questionnaire subscales in 57 typical developing subjects (34F; mean age: 32.7 ± 9.3).ResultsWe found significant results only for the sensation seeking (STS) subscale. Positive and negative correlations emerged with fractional anisotropy (FA) and radial diffusivity (RD) in anterior thalamic radiation, optic radiation, superior longitudinal fasciculus, corpus callosum, and the cingulum bundle. No correlation between sensation seeking and whole brain cortical thickness was found.DiscussionOverall, our results suggest a positive correlation between sensation seeking and higher white matter structural integrity in those tracts mainly involved in visuospatial processing but no correlation with gray matter structure. The enhanced structural integrity associated with sensation seeking may reflect a neurobiological substrate linked to active research of sensory stimuli and resilience to major psychiatric disorders like schizophrenia, bipolar disorder, and depression.
Open-labeled, multicenter phase II study of prophylactic administration of pegylated granulocyte colony-stimulating factor in relapsed or refractory multiple myeloma who received pomalidomide-based regimens (KMM170)
Authors: Song Ga-Young , Lee Je-Jung , Moon Joon Ho , Kim Dajung , Kim Min Kyoung , Kim Hyo Jung , Mun Yeung-Chul , Lee Won-Sik , Do Young Rok , Lee Jae Hoon , Jung Sung-Hoon , Kim Jin Seok 
Published: October 2023

IntroductionPegylated granulocyte colony-stimulating factor (G-CSF) has been widely used for preventing febrile neutropenia in various types of cancer treatment. In the present study, we prospectively evaluated the safety and efficacy of pegfilgrastim as a primary prophylaxis of febrile neutropenia and infection among patients with relapsed refractory multiple myeloma (RRMM) treated with pomalidomide-based regimens.MethodsThirty-three patients with RRMM who received pomalidomide and dexamethasone (Pd) with or without cyclophosphamide (PCd) were enrolled in this study. Twenty-eight patients were treated with PCd and 5 patients were treated with Pd. All patients were given pegfilgrastim subcutaneously with a single administration performed on the first day of each cycle as primary prophylaxis until the fourth cycle.ResultsThe median age of the patients was 75 (range 56-85), and the median prior line of therapy was 2 (range 2-6). Seventeen patients (51.5%) had any grade of neutropenia and 20 (60.6%) had any grade of thrombocytopenia before starting pomalidomide treatment. During the 4 cycles of treatment, grade 3 or more neutropenia occurred in 17 patients (51.5%), and 4 (12.1%) experienced grade 3 or more febrile neutropenia. Grade 3 or more infections occurred in 5 patients (15.2%). Interestingly, the patients with markedly increased ANC of more than 2 x 109/L compared to baseline ANC after 7 days of pegfilgrastim at 1st cycle of treatment showed a significantly lower incidence of grade 3-4 neutropenia. The most common adverse event of pegfilgrastim was fatigue, and all the adverse events caused by pegfilgrastim were grade 1 or 2. And there was no significant change in the immune cell population and cytokines during the administration of pegfilgrastim.DiscussionConsidering that this study included elderly patients with baseline neutropenia, pegylated G-CSF could be helpful to prevent severe neutropenia, febrile neutropenia, or infection in patients with RRMM.