bluuebunny/crossref_metadata_2025_split huggingface dataset:
A multi-variable predictive warning model for cervical cancer using clinical and SNPs data
Authors: Li Xiangqin , Ning Ruoqi , Xiao Bing , Meng Silu , Sun Haiying , Fan Xinran , Li Shuang 
Published: February 2024

IntroductionCervical cancer is the fourth most common cancer among female worldwide. Early detection and intervention are essential. This study aims to construct an early predictive warning model for cervical cancer and precancerous lesions utilizing clinical data and simple nucleotide polymorphisms (SNPs).MethodsClinical data and germline SNPs were collected from 472 participants. Univariate logistic regression, least absolute shrinkage selection operator (LASSO), and stepwise regression were performed to screen variables. Logistic regression (LR), support vector machine (SVM), random forest (RF), decision tree (DT), extreme gradient boosting(XGBoost) and neural network(NN) were applied to establish models. The receiver operating characteristic (ROC) curve was used to compare the models’ efficiencies. The performance of models was validated using decision curve analysis (DCA).ResultsThe LR model, which included 6 SNPs and 2 clinical variables as independent risk factors for cervical carcinogenesis, was ultimately chosen as the most optimal model. The DCA showed that the LR model had a good clinical application.DiscussionThe predictive model effectively foresees cervical cancer risk using clinical and SNP data, aiding in planning timely interventions. It provides a transparent tool for refining clinical decisions in cervical cancer management.
Implantation accuracy of novel polyimide stereotactic electroencephalographic depth electrodes—a human cadaveric study
Authors: Kullmann Aura , Akberali Farida , Van Gompel Jaime J. , McGovern Robert A. , Marsh W. Richard , Kridner Debra , Diaz-Botia Camilo A. , Park Michael C. 
Published: February 2024

IntroductionStereoelectroencephalography (sEEG) is a minimally invasive procedure that uses depth electrodes stereotactically implanted into brain structures to map the origin and propagation of seizures in epileptic patients. Implantation accuracy of sEEG electrodes plays a critical role in the safety and efficacy of the procedure. This study used human cadaver heads, simulating clinical practice, to evaluate (1) neurosurgeon's ability to implant a new thin-film polyimide sEEG electrode according to the instructions for use (IFU), and (2) implantation accuracy.MethodsFour neurosurgeons (users) implanted 24 sEEG electrodes into two cadaver heads with the aid of the ROSA robotic system. Usability was evaluated using a questionnaire that assessed completion of all procedure steps per IFU and user errors. For implantation accuracy evaluation, planned electrode trajectories were compared with post-implantation trajectories after fusion of pre- and postoperative computer tomography (CT) images. Implantation accuracy was quantified using the Euclidean distance for entry point error (EPE) and target point error (TPE).ResultsAll sEEG electrodes were successfully placed following the IFU without user errors, and post-implant survey of users showed favorable handling characteristics. The EPE was 1.28 ± 0.86 mm and TPE was 1.61 ± 0.89 mm. Long trajectories (&gt;50 mm) had significantly larger EPEs and TPEs than short trajectories (&lt;50 mm), and no differences were found between orthogonal and oblique trajectories. Accuracies were similar or superior to those reported in the literature when using similar experimental conditions, and in the same range as those reported in patients.DiscussionThe results demonstrate that newly developed polyimide sEEG electrodes can be implanted as accurately as similar devices in the marker without user errors when following the IFU in a simulated clinical environment. The human cadaver ex-vivo test system provided a realistic test system, owing to the size, anatomy and similarity of tissue composition to that of the live human brain.
Motion planning framework based on dual-agent DDPG method for dual-arm robots guided by human joint angle constraints
Authors: Liang Keyao , Zha Fusheng , Guo Wei , Liu Shengkai , Wang Pengfei , Sun Lining 
Published: February 2024

IntroductionReinforcement learning has been widely used in robot motion planning. However, for multi-step complex tasks of dual-arm robots, the trajectory planning method based on reinforcement learning still has some problems, such as ample exploration space, long training time, and uncontrollable training process. Based on the dual-agent depth deterministic strategy gradient (DADDPG) algorithm, this study proposes a motion planning framework constrained by the human joint angle, simultaneously realizing the humanization of learning content and learning style. It quickly plans the coordinated trajectory of dual-arm for complex multi-step tasks.MethodsThe proposed framework mainly includes two parts: one is the modeling of human joint angle constraints. The joint angle is calculated from the human arm motion data measured by the inertial measurement unit (IMU) by establishing a human-robot dual-arm kinematic mapping model. Then, the joint angle range constraints are extracted from multiple groups of demonstration data and expressed as inequalities. Second, the segmented reward function is designed. The human joint angle constraint guides the exploratory learning process of the reinforcement learning method in the form of step reward. Therefore, the exploration space is reduced, the training speed is accelerated, and the learning process is controllable to a certain extent.Results and discussionThe effectiveness of the framework was verified in the gym simulation environment of the Baxter robot's reach-grasp-align task. The results show that in this framework, human experience knowledge has a significant impact on the guidance of learning, and this method can more quickly plan the coordinated trajectory of dual-arm for multi-step tasks.
Imaging features of ALK-positive histiocytosis with neurological involvement: a case report and literature review
Authors: Wang Juan , Zheng Yan , Xiong Ying 
Published: February 2024

BackgroundALK-positive histiocytosis is an exceptionally rare neoplasm of histiocytes that predominantly involves the nervous system and can also affect the skin and other parts of the body. Previous relevant literature has provided limited information regarding the imaging manifestations of this disease with neurological involvement.MethodsWe reported a case of ALK-positive histiocytosis with multisystem involvement. Together with a comprehensive literature review, the imaging characteristics of this disease in the nervous system were summarized.ResultsA 3-year-old girl with abdominal pain and ambulation difficulty checked in at the Department of Pediatric Neurology. The initial diagnosis was “acute cerebellitis with ataxia” based on the elevated protein level in the cerebrospinal fluid (CSF). However, despite 3 months of treatment, her condition deteriorated. MRI showed an oval-shaped, intradural extramedullary nodule at the T6–T7 level. The patient was ultimately diagnosed as ALK-positive histiocytosis, accompanied by cauda equina and skin involvement. The literature review showed a total of 23 patients who had involvement of the nervous system and provided imaging descriptions. Together with our case, the imaging features were summarized as follows: iso-dense or slightly hyperdense on computed tomography (CT), isointense or iso-hypointense on T2-weighted imaging (T2WI), moderate homogeneous enhancement with mildly/markedly punctate enhancement or/and smooth ring enhancement on contrast-enhanced T1-weighted imaging (T1WI), restricted diffusion on diffuse weighted imaging (DWI), and elevated fluorodeoxyglucose (FDG) uptake on positron-emission tomography/computed tomography (PET/CT).ConclusionThe multimodal imaging findings of ALK-positive histiocytosis exhibit distinct characteristics, familiarity with which will enhance radiologists’ expertise and facilitate accurate diagnosis of this disease.
Significance of cervical secretion culture in predicting maternal and fetal outcome in pregnant women with premature rupture of membranes: a retrospective cohort study
Authors: Wang Zhenna , Xiu Xiaoyan , Zhong Liying , Wang Yi , Fang Zhuanji , Lin Shunhe , Huang Huihui 
Published: February 2024

Background: To investigate the clinical value of cervical secretion culture in pregnant women with premature rupture of membranes (PROM) in predicting maternal and fetal outcomes.Methods: We retrospectively reviewed clinical records of pregnant women who underwent obstetric examination and delivered in Fujian Maternal and Child Healthcare from December 2013 to December 2016. Pregnant women with a clear diagnosis of PROM, who underwent cervical secretion culture immediately after hospital admission were selected for the study. The primary outcome was the occurrence of chorioamnionitis. The secondary outcome was neonatal admission to the neonatal intensive care unit (NICU). Correlation between maternal and fetal outcomes and the results of the cervical secretion culture was analyzed by one-way analysis and multifactorial analysis, respectively. The predictive efficacy of cervical secretion culture was evaluated using receiver operating characteristic curve (ROC), area under the curve (AUC) and the integrated discrimination improvement (IDI).Results: A total of 7,727 pregnant women with PROM were included in the study. Of them, 1812 had positive cervical secretion cultures (635 positive for mycoplasma infection, 475 for bacterial, 637 for fungal, and 65 for chlamydial infections). Pregnant women with positive mycoplasma and bacterial cultures had higher rates of developing chorioamnionitis compared to women with negative cervical secretion cultures (9%, 12% vs. 1%, respectively). Similarly, positive mycoplasma and bacterial cultures were associated with higher rate of the preterm (before 34 weeks) labor (3%, 3% vs. 1% in women with negative cultures, respectively), and neonatal admission to the NICU (9%, 11% vs. 7%, respectively). After adjusting for various confounding factors, our analysis demonstrated that a positive cervical secretion culture for mycoplasma or bacterial pathogens remained an independent risk factor for chorioamnionitis. Cervical secretion culture outcome was less effective in predicting chorioamnionitis (AUC 0.569) compared to white blood count (WBC) (AUC 0.626) and C-reactive protein (CRP) levels (AUC 0.605). The IDI of the combined predictive model incorporating WBC, CRP, maternal fever and cervical secretion culture results was 0.0029.Conclusion: Positive cervical secretion cultures, especially for mycoplasma and bacteria, are associated with higher incidence of adverse maternal and fetal outcomes. However, the predictive value of this test is poor, and cannot be efficiently used for predicting chorioamnionitis.
Twice-daily rivaroxaban after percutaneous left atrial appendage closure for atrial fibrillation
Authors: Pan Yang-Qi , Jin Lu-Shen , Qian Sang , Jiang Ting , Wang Zhe-Ning , Chen Yi-Lian , Qiu Yi-Xuan , Wu Yi-Hao , Fu Jia-Yang , Li Ling , Lin Yuan-Nan , Li Yue-Chun 
Published: February 2024

Background and aim: Rivaroxaban is an emerging oral anticoagulant for postoperative anticoagulation after percutaneous left atrial appendage closure (LAAC). Because a once-daily dosing regimen of rivaroxaban causes fluctuations in the drug plasma concentration, we studied the feasibility and safety of twice-daily rivaroxaban as a postoperative anticoagulation regimen for patients with atrial fibrillation (AF) undergoing LAAC.Methods: This study involved patients with AF who underwent LAAC and took rivaroxaban postoperatively. A total of 326 patients who received a standard total dose (15 or 20 mg) of rivaroxaban based on their creatinine clearance rate were divided into the twice-daily (BID) rivaroxaban group (n = 208) and once-daily (QD) rivaroxaban group (n = 118) according to their anticoagulation strategy. Transesophageal echocardiography was recommended at 3–6 months postoperatively to check for device-related thrombosis (DRT). Clinical outcomes were evaluated during postoperative anticoagulation.Results: The median CHA2DS2-VASc score (4 [3, 5] vs. 4 [3, 5], p = 0.28) and HAS-BLED score (2 [2, 3] vs. 2 [2, 3], p = 0.48) were not significantly different between the groups. During the anticoagulation period (4.1 ± 0.7 vs. 4.1 ± 0.9 months, p = 0.58), 148 (71.2%) patients in the BID group and 75 (63.6%) in the QD group underwent follow-up transesophageal echocardiography. There were no statistically significant differences between the two groups in terms of DRT (1.4% vs. 2.7%, p = 0.60), minor bleeding (8.2% vs. 11.0%, p = 0.39), thromboembolic events (1.0% vs. 0.8%, p = 1.00), major bleeding (0.5% vs. 0.8%, p = 1.00), or death.Conclusion: A short course of twice-daily rivaroxaban following LAAC is a feasible alternative regimen with a low rate of major bleeding events, DRT, and thromboembolic events for patients with AF.
Silicon kerf loss as a potential anode material for lithium-ion batteries
Authors: Søiland Anne-Karin , de Meatza Iratxe , Muguruza Ane , Xu Yijiang , Bellmann Martin 
Published: February 2024

In this work, industrially processed silicon kerf loss (abbreviated to silicon kerf) from the photovoltaic industry is assessed as an anode material for the lithium-ion battery (LIB). The study includes both a characterization of processed silicon kerf from different sources and a comparison with commercially available nano-sized silicon (40 and 100 nm) in electrochemical testing. Such a direct comparison between these two silicon types in electrochemical testing provides a new insight into silicon kerf as an anode material. The silicon kerf particles are flake-like with varying lengths, with a mean particle size (d50) measured to ∼700 nm and a dimension of thickness of a few tens of nanometers. However, the specific surface area ranging from 20 to 26 m2/g is comparable to that of a silicon material of size ∼100 nm. The silicon oxide layer surrounding the particles was measured to 1–2 nm in thickness and, therefore, is in a suitable range for the LIB. In terms of electrochemical performance, the silicon kerf is on par with the commercial nano-sized silicon, further supporting the size evaluation based on the specific surface area considerations. Initial discharge capacities in the range 700–750 mAh/g (close to the theoretical value for the 12 wt% Si mixture with graphite) and first cycle efficiencies of 86%–92% are obtained. The cycling stability is comparable between the two materials, although the differential voltage analysis (DVA) of the galvanostatic data reveals that only the silicon kerf samples maintain silicon activity beyond 120 cycles. This study shows that industrially processed silicon kerf has characteristics similar to nano-sized silicon without reducing the size of the silicon kerf particles themselves. Considering its low carbon footprint and potentially lower cost, it can thus be an attractive alternative to nano-sized silicon as an anode material for the LIB industry.
Analysis of factors associated with the first lumpy skin disease outbreaks in naïve cattle herds in different regions of Thailand
Authors: Arjkumpa Orapun , Wachoom Wanwisa , Puyati Bopit , Jindajang Sirima , Suwannaboon Minta , Premashthira Sith , Prarakamawongsa Tippawon , Dejyong Tosapol , Sansamur Chalutwan , Salvador Roderick , Jainonthee Chalita , Punyapornwithaya Veerasak 
Published: February 2024

IntroductionThailand experienced a nationwide outbreak of lumpy skin disease (LSD) in 2021, highlighting the need for effective prevention and control strategies. This study aimed to identify herd-level risk factors associated with LSD outbreaks in beef cattle herds across different regions of Thailand.MethodsA case–control study was conducted in upper northeastern, northeastern, and central regions, where face-to-face interviews were conducted with farmers using a semi-structured questionnaire. Univariable and multivariable mixed effect logistic regression analyses were employed to determine the factors associated with LSD outbreaks. A total of 489 beef herds, including 161 LSD outbreak herds and 328 non-LSD herds, were investigated.Results and discussionResults showed that 66% of farmers have operated beef herds for more than five years. There were very few animal movements during the outbreak period. None of the cattle had been vaccinated with LSD vaccines. Insects that have the potential to act as vectors for LSD were observed in all herds. Thirty-four percent of farmers have implemented insect control measures. The final mixed effect logistic regression model identified herds operating for more than five years (odds ratio [OR]: 1.62, 95% confidence interval [CI]: 1.04–2.53) and the absence of insect control management on the herd (OR: 2.05, 95% CI: 1.29–3.25) to be associated with LSD outbreaks. The implementation of insect-vector control measures in areas at risk of LSD, especially for herds without vaccination against the disease, should be emphasized. This study provides the first report on risk factors for LSD outbreaks in naïve cattle herds in Thailand and offers useful information for the development of LSD prevention and control programs within the country’s context.
Biochemical Profile and Antioxidant Activity of Dried Fruit Produced from Apricot Cultivars Grown in Latvia
Authors: Juhnevica-Radenkova Karina , Krasnova Inta , Seglina Dalija , Kaufmane Edite , Gravite Ilze , Valdovska Anda , Radenkovs Vitalijs 
Published: February 2024

The present study focused on evaluating the biochemical profiles of four apricot cultivars (cv.) (Prunus armeniaca L.) grown in Latvia and demonstrating their processing to obtain the food product, dried candied fruit (DCF). The fingerprinting of apricot fruit approached by LC-MS and ultraviolet–visible spectroscopy revealed the abundance of bioactives responsible for the antioxidant activity. The outstanding composition of group compounds, i.e., phenolics, flavonoids, and vitamin C, was observed in the cv. ‘Dimaija’, followed by cv. ‘Gundega’ and cv. ‘Velta’. The lowest values were found in the cv. ‘Boriss’ and fruit from a market of Greek origin. However, the latter two contained the highest carotenoid levels due to a more pronounced maturity. Amongst the 13 individual phenolics detected, rutin, chlorogenic and neochlorogenic acids, catechin, and epicatechin prevailed. The concentrations observed were the highest in cv. ‘Dimaija’, followed by cv. ‘Velta’ and cv. ‘Gundega’. Osmotic dehydration and convective drying of apricot fruit variedly influenced the content of bioactives in DCF products. The most substantial decrease due to thermal lability was observed in the vitamin C content in DCF, accounting for a 95.3% loss for all cultivars. The content of total phenolics, flavonoids, and carotenoids in DCF, on average, was 62.7%, 49.6%, and 87.6% lower than that observed in the raw fruit, respectively. On average, the content of individual phenolics in DCF, such as rutin and chlorogenic acid, decreased by 63.8% and 20.8%, respectively. The decline in the content of bioactives was conditioned by the physical migration of the cell components to the hypertonic solution. However, the increase in the content of cell wall-bound phytochemicals, such as catechin and epicatechin, after osmotic dehydration and convective drying, was observed in DCF, corresponding to a 59.5% and 255.64% increase compared with the raw fruit, respectively. Panelists generally responded positively to the developed DCF; however, greater preference was given to products with a lower phenolic content, such as cv. ‘Boriss’ and those produced from the market fruit. It is believed that the high flavan-3-ols content, along with chlorogenic acid, contributed to the bitter taste of DCF. Overall, apricot fruits represent the abundance of bioactives retained in DCF after osmotic dehydration and convective drying. The findings observed in the current study allow to consider DCF as a functional food; however, given the high sugar content, their consumption should be in moderation.
batalla de la vuelta de Obligado y sus representaciones. Fuentes de información, expectativas arqueológicas, técnicas y algunos resultados
Authors: Ramos Mariano , Helfer Verónica , Lanza Matilde , Darigo Mariano , Dottori Carolina , Sportelli Paola , Sulich Keila , Warr Matías 
Published: February 2024

En este trabajo presentamos un conjunto de representaciones sobre la batalla de la Vuelta de Obligado, localidad de Partido de San Pedro en el nordeste Provincia de Buenos Aires ocurrida en noviembre de 1845 en el marco de lo que se conoce como la Guerra del Paraná (1845-1846). En este conjunto incluimos varios tipos: litografías, grabados, dibujos, acuarelas, pinturas, etc. que provienen de publicaciones, museos y otros reservorios locales y extranjeros. Acerca de otras, como daguerrotipos y fotografías, se duda de su existencia por varias razones que aquí se discuten concisamente. En el desarrollo del trabajo analizamos aspectos del contenido de cada una de esas representaciones que conforman una fuente de información con relación a una investigación como la que venimos desarrollando desde hace más de veinte años.
Este trabajo desarrolla perspectivas epistemológicas, teóricas y técnicas. Estas últimas al ser aplicadas en trabajo de campo, requieren de posteriores evaluaciones y ajustes. Al final destacamos que todas las líneas del estudio, fundadas en distintas fuentes de investigación, apuntan a un mejor conocimiento del evento y del proceso bélico. Asimismo, la conformación de estos registros nos permite contar con nuevas perspectivas para la construcción de la identidad y la memoria.
Penerapan Teknologi Peningkatan Penggunaan Panel Surya untuk Energi Mandiri di Rumah Gemilang Indonesia Depok
Authors: Khairul Auni , Subakti Subakti , Putra Geordiano , Alamsyah Rahmadina , Rahmatia Suci , Lubis Ahmad Husin , Astharini Dwi 
Published: February 2024

<p><em>Rumah Gemilang Indonesia (RGI) adalah unit program pemberdayaan dan pusat pelatihan dalam binaan Lembaga Amil Zakat Nasional (LAZ) Al Azhar dengan format pesantren singkat. Pada </em><em>k</em><em>ampus Depok yang merupakan kampus utama RGI, telah dilakukan pemasangan solar panel pada 2022 untuk menghasilkan energi mandiri, namun masih terdapat </em><em>permasalahan</em><em> terkait perangkat penyimpanan energi dan pengaturan aliran energi ke beban dan ke penyimpanan. Pada </em><em>kegiatan </em><em>ini</em><em> dilakukan penerapan teknologi yaitu peningkatan</em><em> penggunaan solar panel di RGI Depok. Solusi yang ditawarkan </em><em>adalah</em><em> menyelesaikan permasalahan sistem penyimpanan daya oleh tim abdimas dengan melibatkan pihak RGI secara teknis. </em><em>Langkah kegiatan meliputi</em><em> pengambilan data teknis awal, p</em><em>enyiap</em><em>an perangkat</em><em>,</em><em> instalasi,</em><em> pemantauan,</em><em> dan evaluasi. Keseluruhan pelaksanaan melibatkan mitra yaitu tutor, peserta, dan pengelola RGI. </em><em>K</em><em>egiatan </em><em>tahun 2023 telah m</em><em>eningkat</em><em>k</em><em>an p</em><em>asokan </em><em>panel surya</em><em> harian</em><em> </em><em>dari 5.24 Kwh menjadi 16.25 Kwh</em><em>, serta menambah fitur </em><em>pemantauan system berbasis IoT yang meningkatkan keterlibatan mitra khususnya tim computer dan jaringan RGI.</em></p><p><strong>Kata kunci<em>:</em></strong><strong><em> </em></strong><strong><em>Panel Surya, Energi Mandiri, Rumah Gemilang Indonesia, IoT</em></strong></p>