bluuebunny/crossref_metadata_2025_split huggingface dataset:
The Impact of Social Work Services on the Quality of Care in Mental Health Complex in Jeddah: A Study of Healthcare Professionals’ Perceptions
Authors: Alkhaldi Waseem Mohammed , Abuatallah Ohoud Fouad , AL-Ghamdi Nesreen Abdullah , Allahyani Bandar , Alghamdi Salman Safar , Alqarni Mohammed Ali , Alzahrani Ibrahim Abdullah 
Published: December 2023

Aim: This study aims to investigate the influence of social work services on the quality of care at Eradah and Mental Health Complex in Jeddah.
Duration of the Study: This study employs one year of conduction from December 2022 to November 2023.
Methods: A cross-sectional study was conducted using the SERVQUL questionnaire as the main scale to assess the degree of social work influence on the overall quality of the healthcare setting to be distributed among selected healthcare workers.
Results: Among randomly selected 240 healthcare workers, among these, 20.8% were aged between 25 and 30 years, the majority (68.3%) were male, about 45.4% had a bachelor’s degree, also, about 67.5% of them were married, 52.5% were laboratory technicians. The results indicated a moderate healthcare rating with a mean score of 58.29 and a moderate healthcare adherence rating with a mean score of 98.37. The results revealed a significant difference in the quality of healthcare among patients due to education (P-value =0.012) and there was a significant difference with job title (p-value = 0.001). However, no significant differences were observed about age, or marital status.
Conclusion: It can be concluded that social work is a crucial type of work that must be implemented among healthcare workers to enhance cooperation and serve society, it has been found that healthcare adherence was rated as moderate. Nevertheless, variables such as age, gender, education level, and marital status did not exert a substantial impact.
Ophthalmic Complications Associated With the Antidiabetic Drugs Semaglutide and Tirzepatide
Authors: Katz Bradley J. , Lee Michael S. , Lincoff Norah S. , Abel Anne S. , Chowdhary Somya , Ellis Brian D. , Najafi Ahmad , Nguyen John , Seay Meagan D. , Warner Judith E. A. 
Published: January 2025

ImportanceNearly 2% of the US population received a prescription for semaglutide in 2023. There has been a recent concern that this drug and other similar medications may be associated with ophthalmic complications.ObjectiveTo report ophthalmic complications associated with the use of semaglutide or tirzepatide.Design, Setting, and ParticipantsThis was a retrospective case series. All patients were initially seen in a community setting. Patients experiencing an ophthalmic complication in association with the use of semaglutide or tirzepatide were included in this analysis.ExposuresPatients described were using either semaglutide or tirzepatide.Main Outcomes and MeasuresVisual acuity and visual field defects.ResultsA total of 9 patients (mean [SD] age, 57.4 [11.6] years; age range, 37-77 years; 5 female [56%]; 4 male [44%]) were included in this study. Seven patients with nonarteritic ischemic anterior optic neuropathy, 1 patient with bilateral papillitis, and 1 patient with paracentral acute middle maculopathy were reported. Atypical features included sequential ischemic optic neuropathy, bilateral disc swelling at presentation, and progressive vision loss.Conclusions and RelevanceIn this case series study, it was not possible to determine if there is a causal link between these drugs and the ophthalmic complications reported. In some cases, it is hypothesized that rapid correction of hyperglycemia induced by these drugs, rather than a toxic effect of the drugs, could be associated with the ophthalmic complications reported.
Synergistic Hybrid‐Ligand Passivation of Perovskite Quantum Dots: Suppressing Reduced‐Dimensionality and Enhancing Optoelectronic Performance
Authors: Han Sanghun , Jeong Woo Hyeon , Seo Gayoung , Choi Seongmin , Lee Dong Gyu , Chae Weon‐Sik , Ahn Hyungju , Lee Tae Kyung , Choi Hyosung , Choi Jongmin , Lee Bo Ram , Kim Younghoon 
Published: January 2025

AbstractIn terms of surface passivation for realizing efficient CsPbI3‐perovskite quantum dot (CsPbI3‐PQD)‐based optoelectronic devices, phenethylammonium iodide (PEAI) is widely used during the ligand exchange. However, the PEA cation, due to its large ionic radius incompatible with the 3D perovskite framework, acts as an organic spacer within polycrystalline perovskites, leading to the formation of reduced dimensional perovskites (RDPs). Despite sharing the identical 3D perovskite framework, the influence of PEAI on the structure of CsPbI3‐PQDs remains unexplored. Here, it is revealed that PEAI can induce the formation of high‐n RDPs (n > 2) within the CsPbI3‐PQD solids, but these high‐n RDPs undergo an undesirable phase transition to low‐n RDPs, leading to the structural and optical degradation of CsPbI3‐PQDs. To address the PEAI‐induced issue, we employ triphenylphosphine oxide (TPPO) as an ancillary ligand during the ligand exchange process. The incorporation of TPPO prevents H2O penetration and regulates the rapid diffusion of PEAI, suppressing the formation of low‐n RDPs. Moreover, TPPO can passivate the uncoordinated Pb2+ sites, reducing the nonradiative recombination. This hybrid‐ligand exchange strategy using both PEAI and TPPO enables realizing efficient and stable CsPbI3‐PQD‐based light‐emitting diode (external quantum efficiency of 21.8%) and solar cell (power conversion efficiency of 15.3%) devices.
Pericytes Promote More Vascularization than Stromal Cells via an Interleukin‐6‐Dependent Mechanism in Microfluidic Chips
Authors: Gonzalez‐Rubio Julian , Kubiza Hannah , Xu Yong , Koenigs‐Werner Hiltrud , Schmitz Mona Sophie , Schedel Michaela , Apel Christian , Jockenhoevel Stefan , Cornelissen Christian G. , Thiebes Anja Lena 
Published: January 2025

AbstractPericytes are a key player in vascularization, protecting endothelial cells from external harm and promoting the formation of new vessels when necessary. However, pericytic identity and its relationship with other cell types, such as mesenchymal stromal/stem cells, is highly debated. This study compares the role of pericytes and unselected stromal cells in vascularization using multichannel microfluidic chips. In both angiogenesis and vasculogenesis, pericytes promote more vessel formation than stromal cells. Pericytes can wrap around endothelial vessels acting as mural cells, while stromal cells remain separated. Whole‐transcriptome sequencing confirms an upregulation of pro‐vascularization genes in endothelial cell‐pericyte co‐cultures, while metabolism increases and inflammation decreases in stromal cell co‐cultures. Treatment of stromal‐endothelial cell co‐cultures with either conditioned media or isolated extracellular vesicles from pericytes replicates the increase in vasculogenesis of the direct co‐cultures. Cytokine quantification reveals that interleukin 6 (IL‐6) is significantly increased in pericyte conditions. Blocking it with siltuximab results in a reduction of pericyte vasculogenic potential comparable to stromal cell levels, revealing that pericyte pro‐vascularization is mediated by IL‐6. This study provides new insights into the relationship between pericytes and endothelial cells and the elusive identity of mesenchymal stromal cells. These findings are relevant for both vascular biology and tissue engineering.
Supramolecular Modulation of Tumor Microenvironment Through Host−Guest Recognition and Metal Coordination to Potentiate Cancer Chemoimmunotherapy
Authors: Wu Dan , Zhou Jie , Zhang Zhankui , Cao Yibin , Ping Kunmin , Qi Shaolong , Du Jianshi , Yu Guocan 
Published: January 2025

AbstractThe massive amount of indoleamine 2,3‐dioxygenase 1 (IDO‐1) in tumor cells and tumor‐associated immune cells forms a feedback loop that maintains immunosuppressive tumor microenvironment (ITM) and causes immune escape, resulting in the poor prognosis of platinum chemotherapeutics. However, the effective systemic administration of platinum drugs and IDO‐1 inhibitors is strictly limited by their distinct chemical construction, different pharmacokinetic profiles, and heterogeneous distributions. Herein, a novel supramolecular method with the capability to modulate tumor microenvironment is proposed aiming at potentiating the antitumor efficacy of chemoimmunotherapy. Profiting from the dynamic and reversible merits of noncovalent interactions, IDO‐1 inhibitor (IDOi) and 1,2‐diaminocyclohexane‐platinum(II) (DACHPt) are tailor‐encapsulated into supramolecular nanoparticles (SNPs) with the aid of host−guest recognition and metal coordination, respectively, effectively increasing the drug loading and improving their pharmacokinetics. In addition to the authorized chemotherapeutical effect, DACHPt performs a systemic antitumor immune response, which is further magnified by the IDOi‐reversed ITM to encourage T lymphocyte infiltration, guaranteeing long‐term antitumor immune responses to improve cancer prognosis.
Elevated SPARC Disrupts the Intestinal Barrier Integrity in Crohn's Disease by Interacting with OTUD4 and Activating the MYD88/NF‐κB Pathway
Authors: Wang Jiayu , He Yuxin , Zhu Xingchao , Zhu Jinghan , Deng Zilin , Zhang Huan , Chen Yanjun , Zhang Guangbo , Shi Tongguo , Chen Weichang 
Published: January 2025

AbstractDisruption of the intestinal epithelial barrier results in increased permeability and is a key factor in the onset and progression of Crohn's disease (CD). The protein SPARC is primarily involved in cell interaction and migration, but its specific role in the intestinal epithelial barrier remains unclear. This study demonstrates that SPARC is significantly overexpressed in both CD patients and murine models of colitis. Furthermore, mice deficient in SPARC exhibits resistance to chemically induced colitis, a phenomenon associated with the modulation of barrier‐associated proteins. Mechanistically, it is elucidated that SPARC competitively binds to OTUD4 in conjunction with MYD88, facilitating the translocation of p65 from the cytoplasm to the nucleus and subsequent activation of the p65‐MLCK/MLC2 pathway, thereby compromising barrier integrity. Additionally, it is identified that the elevated expression of SPARC in CD is regulated via the METTL3‐YTHDF1 axis. These findings indicate that SPARC levels are elevated in patients with CD and in colitis‐induced mice, leading to intestinal barrier damage through direct interaction with OTUD4 and subsequent activation of the MYD88/p65/MLCK/MLC2 signaling pathway. Consequently, targeting SPARC or the OTUD4/MYD88/p65/MLCK/MLC2 axis may offer novel insights into the molecular mechanisms underlying CD and represent a potential therapeutic strategy.
Microneedles at the Forefront of Next Generation Theranostics
Authors: Wang Chan , Yang Yuan , Zhang Jiaqi , Zhang Hanrui , Wang Qian , Ma Shengmei , Zhao Pengfei , Li Zhou , Liu Yuxin 
Published: January 2025

AbstractTheranostics, combining therapeutic and diagnostic functions, marks a revolutionary advancement in modern medicine, with microneedle technology at its forefront. This review explores the substantial developments and multifaceted applications of microneedles, which have evolved from basic transdermal drug delivery devices to sophisticated diagnostic and therapeutic platforms. Microneedles enhance access to biomarkers via interstitial fluid, enabling real‐time monitoring of physiological conditions, such as glucose and hormone levels, thus facilitating continuous health tracking. The evolution of microneedle design from solid to dissolvable forms broadens their utility from mere drug delivery to complex sensing and therapeutic applications, including insulin delivery for diabetes management, vaccination, and gene therapy. This paper delves into the integration of microneedles with wearable technologies, highlighting their role in closed‐loop systems that combine real‐time monitoring with dynamic, precise therapeutic delivery. By addressing gaps in the literature regarding their integrated diagnostic and treatment capabilities, this review underscores the pivotal role of microneedles in personalizing medicine. It concludes with a visionary perspective on the future trajectory of microneedle technology, emphasizing its potential to revolutionize therapeutic strategies through enhanced efficacy, safety, and patient compliance.
Structural Basis and Mechanism of a Unique Haemophore in the Haem‐Iron Acquisition by Riemerella anatipestifer
Authors: Wang Mengying , Zhang Dandan , Tian Xiu , Tong Jiangyang , Yao Yizhou , Wang Mingshu , Zhu Dekang , Jia Renyong , Chen Shun , Zhao Xinxin , Zhang Shaqiu , Huang Juan , Ou Xumin , Tian Bin , Sun Di , He Yu , Wu Zhen , Ouyang Songying , Liu Mafeng , Cheng Anchun 
Published: January 2025

AbstractSeveral bacterial pathogens employ haemophores to scavenge haem from host haemoprotein to obtain an iron source. However, no homologues of well‐characterized haemophores are found in Riemerella anatipestifer, a bacterium belonging to the order Flavobacteriales that encodes haem uptake systems. Herein, a unique haemophore RhuH is characterized in this bacterium. R. anatipestifer used RhuH to grow when duck hemoglobin serves as the sole iron resource. RhuH is secreted as a component of outer membrane vesicles. Recombinant RhuH exhibited a high binding affinity for haem (Kd of 3.44 × 10−11 m) and can extract haem from duck hemoglobin. X‐ray crystallography elucidated the 3D structure of RhuH at 2.85 Å resolution, showing a dimeric conformation with each monomer exhibiting a unique structure. Structure modeling of RhuH‐haem, coupled with mutagenesis, haemin utilization, and binding affinity assays, show that haem is captured in the β‐barrel–like region, displaying the classic iron coordination. The RhuH homologues are predominantly distributed in Weeksellaceae and Flavobacteriaceae. Finally, the homologues of RhuH in Riemerella columbina, Flavobacterium columnare, and Flavobacterium soli are used as a proof of concept, demonstrating that these homologues exhibit conserved structures and functions.
The Multifaceted Roles of BACH1 in Disease: Implications for Biological Functions and Therapeutic Applications
Authors: Wei Xiangxiang , He Yunquan , Yu Yueyang , Tang Sichong , Liu Ruiwen , Guo Jieyu , Jiang Qingjun , Zhi Xiuling , Wang Xinhong , Meng Dan 
Published: January 2025

AbstractBTB domain and CNC homolog 1 (BACH1) belongs to the family of basic leucine zipper proteins and is expressed in most mammalian tissues. It can regulate its own expression and play a role in transcriptionally activating or inhibiting downstream target genes. It has a crucial role in various biological processes, such as oxidative stress, cell cycle, heme homeostasis, and immune regulation. Recent research highlights BACH1's significant regulatory roles in a series of conditions, including stem cell pluripotency maintenance and differentiation, growth, senescence, and apoptosis. BACH1 is closely associated with cardiovascular diseases and contributes to angiogenesis, atherosclerosis, restenosis, pathological cardiac hypertrophy, myocardial infarction, and ischemia/reperfusion (I/R) injury. BACH1 promotes tumor cell proliferation and metastasis by altering tumor metabolism and the epithelial‐mesenchymal transition phenotype. Moreover, BACH1 appears to show an adverse role in diseases such as neurodegenerative diseases, gastrointestinal disorders, leukemia, pulmonary fibrosis, and skin diseases. Inhibiting BACH1 may be beneficial for treating these diseases. This review summarizes the role of BACH1 and its regulatory mechanism in different cell types and diseases, proposing that precise targeted intervention of BACH1 may provide new strategies for human disease prevention and treatment.
PRDX6 Prevents NNMT Ubiquitination and Degradation as a Nonenzymatic Mechanism to Promote Ovarian Cancer Progression
Authors: Wu Xingyun , Luo Li , Wang Mao , Dong Lixia , Fan Jiawu , Zeng Yan , Li Sijia , Wang Kui 
Published: January 2025

AbstractCancer cells cope with oxidative stress for their proliferation and metastasis by equipping antioxidant systems, among which the antioxidant enzymes peroxiredoxins (PRDXs) play crucial roles. However, whether PRDXs exhibit nonenzymatic functions remains unclear. Here, it is shown that the 1‐cysteine PRDX (PRDX6) upregulates nicotinamide N‐methyltransferase (NNMT) to promote the growth and metastasis of ovarian cancer cells, independently of PRDX6's enzymatic activities. Mechanistically, PRDX6 interacts with NNMT to prevent its binding to the E3 ubiquitin ligase tripartite‐motif protein 56 (TRIM56), leading to the inhibition of NNMT ubiquitination at lysine 23 and 210 and suppression of subsequent proteasomal degradation. In addition, PRDX6‐mediated NNMT upregulation activates mitogen‐activated protein kinase (MAPK) signaling, thereby promoting the growth and metastasis of ovarian cancer cells. Notably, PRDX6 overexpression is associated with higher NNMT protein levels in human ovarian cancer tissues and is predictive of poor prognosis of ovarian cancer patients. Overall, the findings illustrate a critical oncogenic mechanism of the antioxidant enzyme PRDX6 in promoting ovarian cancer progression beyond its enzymatic mechanisms.
Length‐Based Stock Assessment of the Mackerel Scad, Decapterus macarellus (Cuvier, 1833) From the Tanzanian Coastal Waters
Authors: Sululu Joseph Salawa , Lugendo Blandina Robert , Tuda Paul , Benno Benaiah Lameck 
Published: January 2025

ABSTRACTThis study aimed to conduct a stock assessment of Decapterus macarellus from Tanzanian coastal waters to determine its current stock status and provide appropriate management recommendations. We used a suite of length‐based methods, including the Electronic Length Frequency Analysis (ELEFAN) programme to estimate growth parameters and catch curves to evaluate exploitation fishing and mortality parameters; Length‐Based Spawning Potential Ratio (LBSPR) to calculate the spawning potential ratio (SPR), length‐based indicators (LBI) to assess sustainable fishing levels and length‐based reference point (LBRP) to determine the target reference point (RP) for stock spawning biomass (SB). The results indicated that this small pelagic species grows fast, with a growth rate (K) of 0.74 year−1 and a growth performance index (Ф′) of 2.88. However, the stock is currently at risk of overfishing due to high fishing pressure (F/M > 1) and an elevated exploitation rate (E = 0.71), which resulted in a very low SPR (SPR = 0.11) and SB below the target RP. Yield‐per‐recruit analysis revealed that the current fishing effort (Fcurr = 2.57) far exceeded the precautionary limit (F0.1) and surpassed the fishing mortality rate that maximizes yield per recruit (Fmax = 1.73). This excessive effort largely impacted mega‐spawners, reducing their proportion in the catch to a critically low percentage (9%). On the basis of these findings, the study recommends reducing the current fishing effort to F0.1 (0.84) by limiting the number of ring nets, implementing seasonal closures during peak spawning periods and operating in deeper waters (40–200 m) to protect juveniles and minimize mega‐spawner capture.
The changing biodiversity of the Arctic flora in the Anthropocene
Authors: Markley Paul T. , Gross Collin P. , Daru Barnabas H. 
Published: January 2025

AbstractThe plants of the circumpolar Arctic occupy a dynamic system that has been shaped by glacial cycles and climate change on evolutionary timescales. Yet rapid climatic change can compromise the floristic diversity of the tundra, and the ecological and evolutionary changes in the Arctic from anthropogenic forces remain understudied. In this review, we synthesize knowledge of Arctic floral biodiversity across the entirety of the region within the context of its climatic history. We present critical gaps and challenges in modeling and documenting the consequences of anthropogenic changes for Arctic flora, informed by data from the Late Quaternary (~20 ka). We found that previous forecasts of Arctic plant responses to climate change indicate widespread reductions in habitable area with increasing shrub growth and abundance as a function of annual temperature increase. Such shifts in the distribution and composition of extant Arctic flora will likely increase with global climate through changes to the carbon cycle, necessitating a unified global effort in conserving these plants. More data and research on the continuity of tundra communities are needed to firmly assess the risk climate change poses to the Arctic.
De Novo Chromosomes 3q and 5q Chromothripsis Leads to a 5q14.3 Microdeletion Syndrome Presentation: Case Report and Review of the Literature
Authors: Corriveau Melina L. , Korb Joshua C. , Michener Sydney L. , Owen Nichole M. , Wilson Erica L. , Kubala Jamie , Turner Alicia , Takacs Danielle S. , Potocki Lorraine , Swann John W. , Xue Mingshan , Dai Hongzheng , Chao Hsiao‐Tuan 
Published: January 2025

ABSTRACT5q14.3 microdeletion syndrome (MIM#613443) is a neurodevelopmental disorder (NDD) involving copy number loss of multiple genes including Myocyte enhancer factor 2C (MEF2C) gene in the q14.3 region of chromosome 5. Chromosomes 5 and 15 chromothripsis involving 5q14.3 was previously reported in one individual with developmental epileptic encephalopathy (DEE). A complex chromothripsis between chromosomes 3, 5, 7, 9, and 18 that involved 5q14.3 was also reported in a pregnancy complicated by brain and kidney anomalies on fetal ultrasound. Here, we report chromothripsis of chromosomes 3q and 5q involving 5q14.3 in a three‐year‐old female with Lennox–Gastaut syndrome. The chromosomes 3q and 5q chromothripsis was found by trio genome sequencing (GS) and confirmed by fluorescent in situ hybridization (FISH). Notable clinical findings include medically refractory seizures, global developmental delay, increased fluid‐attenuated inversion recovery (FLAIR) signal in the left inferior temporal gyrus, and dysmorphic features. Chromothripsis of chromosomes 3 and 5 was previously recognized in renal cell carcinomas. To the best of our knowledge, this is the first reported case of chromosomes 3q and 5q chromothripsis leading to a developmental epileptic encephalopathy (DEE) due to disruption of 5q14.3. These findings expand chromosomes 3 and 5 chromothripsis as a genomic mechanism underlying 5q14.3 microdeletion syndrome.