bluuebunny/crossref_metadata_2025_split huggingface dataset:
Optimal social distancing in epidemic control: cost prioritization, adherence and insights into preparedness principles
Authors: Pisaneschi Giulio , Tarani Matteo , Di Donato Giovanni , Landi Alberto , Laurino Marco , Manfredi Piero 
Published: February 2024

AbstractThe COVID-19 pandemic experience has highlighted the importance of developing general control principles to inform future pandemic preparedness based on the tension between the different control options, ranging from elimination to mitigation, and related costs. Similarly, during the COVID-19 pandemic, social distancing has been confirmed to be the critical response tool until vaccines become available. Open-loop optimal control of a transmission model for COVID-19 in one of its most aggressive outbreaks is used to identify the best social distancing policies aimed at balancing the direct epidemiological costs of a threatening epidemic with its indirect (i.e., societal level) costs arising from enduring control measures. In particular, we analyse how optimal social distancing varies according to three key policy factors, namely, the degree of prioritization of indirect costs, the adherence to control measures, and the timeliness of intervention. As the prioritization of indirect costs increases, (i) the corresponding optimal distancing policy suddenly switches from elimination to suppression and, finally, to mitigation; (ii) the “effective” mitigation region—where hospitals’ overwhelming is prevented—is dramatically narrow and shows multiple control waves; and (iii) a delicate balance emerges, whereby low adherence and lack of timeliness inevitably force ineffective mitigation as the only accessible policy option. The present results show the importance of open-loop optimal control, which is traditionally absent in public health preparedness, for studying the suppression–mitigation trade-off and supplying robust preparedness guidelines.
Prevalence and impact of fertility concerns in young women with breast cancer
Authors: Mannion Samantha , Higgins Alexandra , Larson Nicole , Stewart Elizabeth A. , Khan Zaraq , Shenoy Chandra , Nichols Hazel B. , Su H. Irene , Partridge Ann H. , Loprinzi Charles L. , Couch Fergus , Olson Janet E. , Ruddy Kathryn J. 
Published: February 2024

AbstractSurvey data from the Mayo Clinic Breast Disease Registry were used to assess fertility counseling and fertility preservation strategies in a modern cohort of young women with breast cancer. One hundred respondents were identified who were under age 50 at the time of breast cancer diagnosis and who expressed interest in future childbearing near the time of diagnosis and/or 1 year later. Ninety-three percent of the 81 respondents to the year one survey recalled fertility counseling prior to cancer treatment. Most who reported a high level of fertility concern declared that this concern had impacted their treatment decisions, often shortening their planned duration of endocrine therapy. Approximately half had taken steps to preserve future fertility, and a third had used a gonadotropin-releasing hormone agonist either alone or combined with another method (e.g., embryo or oocyte cryopreservation).
COVID-19 vaccine hesitancy and influencing factors among Chinese hospital staff: a cross-sectional study
Authors: Li Shangyao , Hao Jinjuan , Su Yu , Zhan Haoran , Zhou Nuo , Qiu Yitong , Lu Yitong , Sun Ke , Tian Yu 
Published: February 2024

AbstractWe aimed to investigate the willingness of hospital staff to receive the COVID-19 vaccine and explore the associated factors and reasons of vaccine hesitancy among Chinese hospital staff, which were not yet known. A cross-sectional questionnaire survey was conducted online on the vaccine hesitancy of staff in a grade A tertiary general hospital in Beijing from February 22 to 23, 2023. Univariate and multivariate logistic regression were used to assess associations between potential influencing factors and vaccine hesitancy. A total of 3269 valid respondents were included, and the rate of COVID-19 vaccine hesitancy was 32.67%. Multivariate logistic regression showed that women [1.50 (1.22–1.83)], having high-school education level [1.69 (1.04–2.76)], college degree [2.24 (1.35–3.72)] or graduate degree [2.31 (1.33–4.03)], and having underlying disease [1.41 (1.12–1.77)] were associated with a higher rate of COVID-19 vaccine hesitancy. The main reasons for vaccine hesitancy included doubts for the safety and effectiveness of COVID-19 vaccine and worries in adverse reactions. Hospital staff's willingness to vaccinate COVID-19 vaccine is generally high in the study. Hospitals should spread the knowledge of COVID-19 vaccine through multiple channels to improve the cognition of hospital staff and encourage vaccination based on associated factors.
Mass irradiation of adult Aedes mosquitoes using a coolable 3D printed canister
Authors: Balestrino F. , Bimbilé Somda N. S. , Samuel M. , Meletiou S. , Bueno O. , Wallner T. , Yamada H. , Mamai W. , Vreysen M. J. B. , Bouyer J. 
Published: February 2024

AbstractIn the last decade, the use of the sterile insect technique (SIT) to suppress mosquito vectors have rapidly expanded in many countries facing the complexities of scaling up production and procedures to sustain large-scale operational programs. While many solutions have been proposed to improve mass production, sex separation and field release procedures, relatively little attention has been devoted to effective mass sterilization of mosquitoes. Since irradiation of pupae en masse has proven difficult to standardise with several variables affecting dose response uniformity, the manipulation of adult mosquitoes appears to be the most promising method to achieve effective and reliable sterilization of large quantities of mosquitoes. A 3D-printed phase change material based coolable canister was developed which can compact, immobilize and hold around 100,000 adult mosquitoes during mass radio sterilization procedures. The mass irradiation and compaction treatments affected the survival and the flight ability of Aedes albopictus and Aedes aegypti adult males but the use of the proposed irradiation canister under chilled conditions (6.7–11.3 °C) significantly improved their quality and performance. The use of this cooled canister will facilitate adult mass irradiation procedures in self-contained irradiators in operational mosquito SIT programmes.
Safety and efficacy of one-hole split endoscope technique for surgical treatment of thoracic ossification of the ligamentum flavum
Authors: Sha Qi , Huang Zhengdong , Liu Jinhao , Ge Peng , Zhang Yong , Song En , Sun Zhaozhong , Zhu Tenyue , Shen Cailiang , Qian Jun 
Published: February 2024

AbstractSurgical intervention is typically recommended for thoracic ossification of the ligamentum flavum (TOLF). This study aimed to evaluate the efficacy and safety of a novel non-coaxial one-hole split endoscope (OSE) technique for treating TOLF. We performed OSE procedure on 13 patients with TOLF from June 2022 to July 2023. The mean operative time was 117.5 ± 15.4 min. VAS scores for lower limbs decreased from 6.5 ± 0.8 preoperative to 1.6 ± 0.4 at the last follow-up (P < 0.001). ODI scores improved from 62.4 ± 5.7 preoperative to 18.6 ± 2.2 at the last follow-up (P < 0.001), and mJOA scores increased from 5.1 ± 1.6 preoperative to 8.4 ± 1.5 at the latest follow-up (P < 0.001). All patients achieved ASIA scale grade D or E at the final follow-up, except for two patients remained residual limb numbness. None of the thirteen patients suffered from severe perioperative complications. The OSE technique proves to be a safe and effective procedure for treating TOLF or even with dura mater ossification, characterized by minimal surgical trauma, relatively smooth learning curve and flexible operation.
Gastrodia elata polysaccharide alleviates Parkinson's disease via inhibiting apoptotic and inflammatory signaling pathways and modulating the gut microbiota
Authors: Gan Qing-xia , Peng Mao-yao , Wei Hao-bo , Chen Lin-lin , Chen Xiao-yan , Li Zi-han , An Guang-qin , Ma Yun-tong 
Published: February 2024

Gastrodia elata polysaccharide significantly alleviated motor dysfunction, inhibited α-synuclein accumulation in PD mice via inhibiting apoptotic and inflammatory signaling pathways and modulating the gut microbiota.
Editorial
Authors: Wiemers Anna , Dillenhöfer Stefanie , Schlegtendal Anne 
Published: February 2024

Liebe Kolleginnen und Kollegen,Wir freuen uns sehr, Euch in Bochum – im Herzen des Ruhrgebiets – zur
45. Jahrestagung der Gesellschaft für Pädiatrische Pneumologie
begrüßen zu dürfen.
Cannabiskonsum im Teenageralter: Ergebnisse des Präventionsradars von
2016 bis 2023
Authors: Hanewinkel Reiner , Hansen Julia 
Published: February 2024

ZusammenfassungTrends des Cannabiskonsums in der Adoleszenz sollen von 2016 bis 2023 abgebildet
werden. Basierend auf sieben Wellen des Präventionsradars, einer schulbasierten
epidemiologischen Studie in der Sekundarstufe I, wurden die Lebenszeit- und
Monatsprävalenzen des Cannabiskonsums von 12-bis 17-Jährigen für den Zeitraum
von 2016 bis 2023 ermittelt. Der Auswertung lagen 54.242 Fragebögen mit Angaben
zum Konsum von Cannabis zugrunde. Das Geschlechterverhältnis war ausgeglichen
(50% weiblich). Das durchschnittliche Alter betrug 13,9 Jahre (SD=1,3). Von 2016
bis zum Ausbruch der COVID-19-Pandemie stieg die Lebenszeitprävalenz des
Cannabiskonsums statistisch bedeutsam an, im ersten Jahr der Pandemie sank sie
signifikant. Post-pandemisch hatten 12,3% (95 % KI: 11,6-13,1) der
Heranwachsenden mindestens einmal in ihrem Leben Cannabis konsumiert. Dieser
Wert liegt auf dem Niveau von 2016. Die Monatsprävalenz des Cannabiskonsums lag
2022/2023 bei 3,8% (95% KI: 3,4-4,3). Sowohl die Lebenszeit- als auch die
Monatsprävalenz des Cannabiskonsums von Jungen liegen signifikant über den
Werten der Mädchen. Angesichts der bekannten Risiken, die mit dem Cannabiskonsum
im Jugendalter einhergehen können, ist es besorgniserregend, dass 2022/2023 etwa
jeder achte Jugendliche bereits mit Cannabis experimentiert hatte. Konsequente
verhältnis- und verhaltenspräventive Maßnahmen sind erforderlich, um den
Cannabiskonsums im Teenageralter einzudämmen.
LemPhos – New P-Chiral Phospholene Core Based Ligand
Authors: Włodarczyk Adam , Ponikiewski Łukasz 
Published: February 2024

AbstractSynthesis and modifications of new chiral phospholene-based scaffolds are described. The construction of base molecules was accomplished via McCormack synthesis. Separation of single P-epimers was accomplished with column chromatography on silica gel.
Economic Cost-Benefit Analysis of Nerve Implanted into Muscle versus Targeted Muscle Reinnervation versus Regenerative Peripheral Nerve Interface, for Treatment of the Painful Neuroma
Authors: Zamore Zachary , Yesantharao Pooja S. , Aravind Pathik , Dellon A. Lee 
Published: February 2024

Abstract
Background This study investigated the relative cost utility of three techniques for the management of symptomatic neuromas after neuroma excision: (1) implantation of nerve into muscle, (2) targeted muscle reinnervation (TMR), and (3) regenerative peripheral nerve interface (RPNI).
Methods The costs associated with each procedure were determined using Common Procedural Terminology codes in combination with data from the Centers for Medicaid and Medicare Services Physician and Facility 2020 Fee Schedules. The relative utility of the three procedures investigated was determined using changes in Patient-Reported Outcomes Measurement Information System (PROMIS) and Numeric Rating Scale (NRS) pain scores as reported per procedure. The relative utility of each procedure was reported in terms of quality-adjusted life years (QALYs), as is standard in the literature.
Results The least expensive option for the surgical treatment of painful neuromas was nerve implantation into an adjacent muscle. In contrast, for the treatment of four neuromas, as is common postamputation, TMR without a microscope was found to cost $50,061.55 per QALY gained, TMR with a microscope was found to cost $51,996.80 per QALY gained, and RPNI was found to cost $14,069.28 per QALY gained. While RPNI was more expensive than nerve implantation into muscle, it was still below the standard willingness-to-pay threshold of $50,000 per QALY, while TMR was not.
Conclusion Evaluation of costs and utilities associated with the various surgical options for the management of painful neuromas suggest that nerve implantation into muscle is the least expensive option with the best improvement in QALY, while demonstrating comparable outcomes to TMR and RPNI with regard to pain symptoms.
Postparetic Synkinesis: Objective and Subjective Comparisons of Depressor Anguli Oris Myectomies versus Depressor Anguli Oris and Buccinator Myectomies
Authors: Sanchez Cristina V. , Ercan Alp , Rozen Shai M. 
Published: February 2024

Abstract
Background Muscles affected by postparetic synkinesis have imbalanced tonicity that limit perioral mimetic movement and inhibit the ability to smile. The depressor anguli oris (DAO) muscle has been a common myectomy target for the treatment of perioral synkinesis. While addition of buccinator myectomies to DAO myectomies has risen, no studies have analyzed the effects of buccinator myectomies. The goal of this study was to evaluate and compare the effects of a DAO myectomy with and without concomitant buccinator myectomy through objective facial metrics and subjective patient-reported outcomes.
Methods This study is a retrospective review of patients with postparetic synkinesis who underwent DAO myectomy (DAO myectomy group) or DAO myectomy with buccinator myectomy (DAO + Buccinator myectomies group). Outcomes included postoperative differences in objective smile measures (smile angle, excursion, and dental show) using validated software and patient-reported outcomes using the Facial Disability Index (FDI) questionnaire and a myectomy-specific questionnaire.
Results After chart review, 18 patients were included in the DAO myectomy group and 19 in the DAO + Buccinator myectomies group. There were no significant postoperative differences between the groups in (1) smile excursion, angle, or dental show at resting, closed smile, or open smile (p > 0.05), (2) FDI physical and social scores, p = 0.198 and 0.932, respectively, or (3) myectomy-specific questionnaire responses (p > 0.05).
Conclusion The addition of a buccinator myectomy to a DAO myectomy does not provide significant clinical benefit when compared with an isolated DAO myectomy, based on objective measures and subjective patient-reported outcomes.
Giant Meningiomas Invading the Cavernous Sinus: The “Inevitable Ones”
Authors: Silva Carlos Eduardo da , Vidaletti Tamara 
Published: February 2024

Abstract
Introduction Giant meningiomas invading the cavernous sinus (GMICSs) are a subgroup of challenging tumors due to their volume and the extent of neurological impairment. Preserving quality of life is one of the most relevant aspects of treating patients with GMICS.
Methods A retrospective study was conducted for surgeries performed between 2012 and 2022, including 33 patients presenting meningiomas with the largest diameter of at least 5 cm invading the cavernous sinus. The data from surgical intervention, Simpson grade of resection, tumor location, and morbimortality related to the surgeries were reviewed.
Results The group comprised 25 women and 8 men with a median age of 56 years. The mean follow-up period was 52 months. The tumors were in the sphenoid wing, anterior clinoid, spheno-orbital, spheno-petroclival, petroclival, and Meckel's cave. Simpson grade I, II, and III were obtained in 70% of cases. The meningiomas were classified as WHO grade 1 in 94%, grade 2 in 3%, and grade 3 in 3%. The overall mortality was 3%. Permanent cranial nerve deficits occurred in 21%, transient cranial nerve deficits in 42%, cerebrospinal fistula in 15%, and hemiparesis in 18%. The recurrence/regrowth rate was 6%. The Karnofsky Performance Status score of 100 and 90 was 82%.
Conclusions The surgical treatment of GMICS is an effective treatment modality with acceptable morbimortality and good long-term control. Involvement of the internal carotid artery is essential to determine the extent of resection inside the cavernous sinus, and training in the microsurgical laboratory is mandatory for safe surgical treatment.
Brain-Derived Neurotrophic Factor is Associated with Self-Reported
Quality of Sleep in Type 2 Diabetes Patients in Ghana
Authors: Agyekum Jennifer Adjepong , Yeboah Kwame 
Published: February 2024

Abstract
Objective Sleep disturbances are common in patients with type 2 diabetes
(T2DM), and this exacerbates disease severity and results in poor quality of
life. Brain-derived neurotrophic factor (BDNF) has been reported to mediate the
association between T2DM and poor sleep health. The burden of self-reported poor
sleep quality and duration in T2DM and their association with serum BDNF levels
were investigated.
Methods In this case-control design, the Pittsburgh Sleep Quality
Instrument was used to assess self-reported sleep quality and duration in 100
patients with T2DM and 80 nondiabetic controls. Sociodemographic data and
medical history were collected from case notes and/or using a structured
questionnaire. Fasting venous blood samples (5 mL) were collected to measure
plasma lipid profile and serum BDNF levels.
Results patients with T2DM had low levels of BDNF, poor sleep quality
(61.9% vs 27.5%, p<0.001), and shorter sleep duration (6.1±2.2 vs 6.9±1.1 h,
p=0.003). T2DM status was associated with doubling the odds of poor sleep
quality [OR (95%CI)=2.06 (1.07–6.43), p=0.039] and 1.6 times the odds of short
sleep duration [1.63 (1.03–3.79), p=0.028]. Multivariable logistic regression
analysis revealed no association between serum BDNF levels and sleep status.
However, there was a negative biological interaction between T2DM and BDNF
levels on poor sleep quality, resulting in 0.28 relative excess risk due to the
interaction and a 12% attributable proportion due to the interaction.
Conclusion In this study population, patients with T2DM had a high burden
of self-reported poor quality of sleep and shorter sleep duration compared to
the nondiabetic controls. T2DM interacts negatively with serum BDNF levels to
affect sleep quality.
Effect of Colchicine Treatment on Clinical Course in Children with
PFAPA Syndrome
Authors: Bagrul İlknur , Aydin Elif Arslanoglu , Tuncez Serife , Baglan Esra , Özdel Semanur , Bülbül Mehmet 
Published: February 2024

Abstract
Introduction Periodic fever, aphthous stomatitis, pharyngitis, and
cervical adenitis syndrome (PFAPA) is the most common periodic fever condition
in children. There is no consensus on treatment to prevent attacks and reduce
their frequency. In this study, we aimed to evaluate the effectiveness of
colchicine treatment in PFAPA syndrome. In addition, we described the
demographic and clinical features of PFAPA patients.
Materials and Methods We retrospectively analyzed 58 PFAPA patients who
were started on colchicine treatment between January 2017 and January 2022.
Demographic data, clinical features, laboratory tests, genetic analysis of
MEditerranean FeVer (MEFV) mutations, and autoinflammatory disease activity
index (AIDAI) scores of all patients were evaluated. In addition, patients were
divided into two groups according to MEFV variants and compared.
Results Attack frequency, duration, and AIDAI scores decreased in all
patients after colchicine treatment. Duration of follow-up was 13.53±6.65
months. The median±IQR age at diagnosis was 3.2 (2–5) years. Thirty three
(56.9%) patients had heterozygous mutations of MEFV. The most common MEFV
variants were M694V (63.6%). There was no significant difference between the two
groups in terms of colchicine responses.
Conclusion Colchicine treatment is effective and safe in patients with
PFAPA who have frequent attacks. No association was established between the
presence of heterozygous mutations of MEFV and colchicine response.
Synthesis of Heterocycles by a C–C Cross-Coupling/Alkyne-Carbonyl-Metathesis Strategy
Authors: Langer Peter 
Published: February 2024

AbstractThe present article presents a personal account on the synthesis of heterocycles by the combination of regioselective Pd-catalyzed cross-coupling reactions of polyhalogenated heterocycles, i.e., Suzuki–Miyaura and Sonogashira reactions, with alkyne-carbonyl-metathesis (ACM) reactions. The products, which show interesting optical, electronic or medicinal properties, are not readily available by other methods.
Failure of Per-Oral Endoscopic Myotomy (POEM) for Achalasia Cardia—LES-Directed Therapy or Esophageal Body Therapy-Directed Therapy?: A Pictorial High-Resolution Esophageal Manometry (HREM) Case-Based Analysis
Authors: Sharma Zubin Dev , Puri Rajesh 
Published: February 2024

AbstractPer-oral endoscopic myotomy (POEM) is one of the main modalities of treatment of achalasia cardia today across subtypes and we are increasingly seeing patients persistent or recurrent symptoms after POEM. An accurate high-resolution esophageal manometry (HREM) is one of the most important tests that can help us guide the treatment in cases of failure of POEM. HREM can help us direct the therapy. The therapy can be lower esophageal sphincter-directed therapy or esophageal body-directed therapy that can be ascertained using HREM. With this review, we detail the factors associated with failure of POEM, tests that can be utilized for its evaluation, and case-based analysis using HREM in patients of post-POEM failure.
Giant Cell Tumor of the Tendon Sheath of the Hand: Analysis of Factors Impacting Recurrence
Authors: Kolisetty Pavan Venkateswar , Ali Sheikh Sarfraz , Ahmad Imran , Sudhy Indrajith K. , Prakash Om , Kishore Y. Ranga 
Published: February 2024

Abstract
Background Giant cell tumors of the tendon sheath (GCTTS) of the hand are considered the second most common benign tumors of the hand after ganglion cysts. Excision biopsy is considered the standard treatment at present. They are notorious for having a very high rate of recurrence as given in many studies. Many factors are said to be associated with recurrence of the tumors. The goal of this study is to evaluate the long-term results of a series of 48 patients operated on at a single institute and to find out if there is any correlation between the proposed risk factors with recurrence.
Methods A retrospective analysis was done in cases of GCTTS operated on between 2015 and 2021. The patients were invited for follow-up for a minimum of 2 years, and the patient files were reviewed. Further data were collected at follow-up including recurrence, range of movement, sensation, skin necrosis, scarring, and digital neuropathy. A data analysis was done. The correlation between the proposed risk factors and recurrence was calculated with the Pearson correlation coefficient. A p-value of less than 0.05 was considered statistically significant.
Results During the 6 years, 48 patients were operated on. Recurrence was observed in eight patients (16%) at an average of 38.7 months from the time of surgery. Of the risk factors, tumors with satellite nodules and tumor adjacency to joint correlated significantly with recurrence. No complications were observed during follow-up.
Conclusion GCTTS of the hand has a high propensity to recur. The presence of satellite nodules and proximity to interphalangeal joints are two important risk factors for recurrence. Magnification during surgery ensures complete excision of the tumor and reduces the chance of recurrence.