bluuebunny/crossref_metadata_2025_split huggingface dataset:
De vroege geschiedenis van de (lokale) bestuurswetenschappen: Antonie Kleijn over de irrationele achterkant van het openbaar bestuur
Authors: Reussing Rik 
Published: October 2023

The early history of (local) administrative sciences: Antonie Kleijn on the irrational reverse side of public administration
Antonie Kleijn belongs to the list of legal scholars who helped shape the early history of (local) administrative sciences in the Netherlands, which was dominated by the legal approach by local government. He held the first chair in Public Administration in the Netherlands in Rotterdam, occupied by Gerrit van Poelje from 1928, left in 1933 and then taken over by Adriaan Koelma (first as a lecturer, from 1946 onwards as a professor) and David Simons (from 1948) from 1957 until his emeritus status in 1971. In his work, Kleijn has mainly dealt with the irrational reverse side of public administration. In contrast to almost all well-known authors on public administration, who invariably view administration from a rational angle, he primarily approaches administration in its irrational aspects. He also looks at the art of administration and the relationship between psychology and administration. The way in which he views the administration differs from his predecessors and is in line with his political and ideological starting points. As a moderate conservative, Kleijn favoured cautious, lived and experienced changes with an eye on the place of the individual within the community.
Les Britanniques et les débuts du rugby en France
Authors: Bourmaud François 
Published: October 2023

Alors que le rugby a connu une diffusion mondiale limitée, l’Hexagone a embrassé ce sport avec enthousiasme. Cette acculturation réussie s’explique en grande partie par les étroites relations tissées entre pratiquants français et britanniques. L’article tente d’analyser ce transfert culturel en revenant sur les premiers joueurs « anglais » des années 1860-1880, puis sur les processus d’ouverture aux autochtones. La transmission du feu sacré est suivie d’une forme de tutelle britannique jusqu’en 1914 : des joueurs, des entraîneurs et des équipes franchissent la Manche et permettent aux pratiquants français de capter les principales évolutions techniques et tactiques d’Albion. Cette relation spéciale trouve sa consécration dans la première participation du XV tricolore au Tournoi des Cinq Nations en 1910.
« La balle dans l’aile, la mort est belle »
Authors: Morata Camille 
Published: October 2023

Le rugby est le sport collectif que l’on a sans doute le plus assimilé à la guerre. Les rugbymen français ont payé un lourd tribut pendant la Première Guerre mondiale. Dès les années du conflit les clubs ont lancé des souscriptions pour édifier des monuments funéraires mêlant attributs militaires et sportifs. Au son des fanfares, leur inauguration mobilise les notabilités politiques et la communauté sportive. La célébration des disparus se fait aussi par l’organisation de matchs de rugby, des banquets au cours desquels les adversaires d’hier se réconcilient. Le culte mémoriel des rugbymen est aussi célébré dans le monde anglosaxon à l’image de Dave Gallaher, premier capitaine des All Blacks mort à Passchendaele. Le rugby à XV n’eut pas l’exclusivité de ces célébrations mémorielles que l’on retrouve dans le XIII et jusque dans le football australien.
John Bull, Marianne et le ballon ovale
Authors: Collins Tony 
Published: October 2023

Le rugby a représenté un aspect non-négligeable des relations franco-britanniques tout au long du vingtième siècle. Ces relations sportives n’ont pas été de tout repos et ont porté les préjugés construits depuis la fin du xviiie siècle par les guerres entre les deux nations. Dès les années 1910-1920, les rugby unions britanniques font valoir de nombreux griefs à l’égard du rugby français. Les rugbymen français seraient soumis à leurs passions, brutaux et, surtout, pratiqueraient de manière presque ouverte le professionnalisme. Ces accusations provoquent l’éviction du quinze de France du Tournoi des Cinq nations en 1931. L’une des conséquences de cette exclusion est le développement du rugby à XIII en France. Malgré le retour des Bleus dans le Tournoi en 1947, les préjugés ont la vie dure mais le dirigeant français René Crabos évite habilement une nouvelle rupture. Désormais, les relations franco-britanniques en matière de rugby sont caractérisées par le déni et le partage d’intérêts bien compris.
Un professionnalisme du pauvre ? Le Rugby Club albigeois (XIII) après la Seconde Guerre mondiale
Authors: Conord Fabien 
Published: October 2023

Le rugby à XIII a eu une histoire difficile sur le sol français en raison de son professionnalisme ouvert et du combat livré contre lui par le XV. L’exemple du Rugby Club albigeois plusieurs fois champion de France et dont les documents comptables sont conservés aux archives départementales du Tarn permet de comprendre comment ce rugby professionnel fonctionne à l’issue de la Seconde Guerre mondiale. L’essentiel des recettes provient sans surprise de la billetterie et sert surtout à payer le salaire de l’entraîneur et les primes et indemnités des joueurs qui ont aussi un métier. Le recrutement est local et les émoluments versés à l’effectif distinguent peu de vedettes, à l’exception du demi d’ouverture Charles Galaup qui devient en 1972 le conseiller technique du rival quinziste local, le Sporting club albigeois. Outre cette défection, le club albigeois du XIII aura eu à subir l’ostracisme d’une partie de la presse locale notamment la Dépêche du Midi.
Maestri d’oltrealpe ? Les Français et l’histoire du rugby italien
Authors: Lucchese Elvis 
Published: October 2023

Dans les années 1930, les entraîneurs français ont joué un rôle important dans le développement du rugby italien avec notamment Julien Saby qui devient l’entraîneur des Amatori Milano et de l’équipe nationale. Les tensions internationales mettent fin à partir de 1938 à ce magistère qui reprend à partir des années 1950. Saby revient en Italie à Rovigo et forme de nombreux joueurs et entraîneurs italiens autour d’un rugby de conquête et de possession. Dans les années 1970, Pierre Villepreux devient un nouveau maestro d’oltrealpe autour d’un rugby de mouvement et de liberté. Saby comme Villepreux veulent ouvrir une voie italienne du rugby. D’autres entraîneurs français font fructifier leur héritage comme Georges Coste, Pierre Berbizier, Jacques Brunel même si l’Italie se tourne aussi vers des entraîneurs de l’hémisphère sud. Ils contribuent à la participation des Azzurri au Tournoi des Six Nation.
VAR, TMO : comparaison sociohistorique de la modernisation de l’arbitrage du football et du rugby au xxie siècle
Authors: Desfontaine Pierrick 
Published: October 2023

Cet article a pour objet l’assistance vidéo à l’arbitrage dans le football (VAR). Cette innovation numérique longtemps refusée par les instances fédérales fait partie d’un ensemble de techniques qui sont venues progressivement outiller les arbitres de l’élite française. Cependant, ces évolutions technologiques sont controversées et génèrent différentes justifications. Bien d’autres sports collectifs utilisent des assistances vidéo, notamment chez le proche cousin rugbystique avec le Television Match Official qui semble fonctionner avec moins de controverses que dans le football. Cette contribution à la sociohistoire de l’arbitrage ambitionne de comparer la dynamique d’implémentation de la VAR avec celle du TMO. La méthodologie se concentre sur les stratégies argumentaires des usagers principaux de ces dispositifs : les arbitres de Ligue 1 et de Top 14.
Approach to the Management of Thyroid Eye Disease
Authors: Yu Sabrina , Yin Vivian T. 
Published: October 2023

Thyroid Eye Disease (TED), also known as Grave’s orbitopathy, is an autoimmune condition characterized by inflammation of the extraocular muscles, orbital fat and periocular tissues. As the most common orbital disease worldwide, its prevalence is estimated to be between 0.5–2% and it disproportionately affects females 4:1. Although the majority of TED cases occur in patients with Graves’ disease (80–90%), it can also be seen with patients with Hashimoto’s thyroiditis (10%), euthyroid individuals (5–10%) and thyroid cancer. At the time of initial Graves’ disease diagnosis, 25% of patients have clinically detectable orbital involvement that is often mild. The natural history of TED typically consists of an initial active inflammatory period lasting 6–36 months, which then plateaus and is followed by a quiescent fibrotic phase with stabilization of disease.
Fish Sanctuaries as an Ecological Approach to Management for Restoring Fish Biodiversity: A Study on Chikadubi Beel Fish Sanctuary, Bangladesh
Authors: Alam Md. Shahin , Ahamed Saokat , Chowdhury Parvez , Rahman Md. Moshiur , Haque Shahroz Mahean 
Published: October 2023

The fish biodiversity of open water is reducing as rice culture has been intensified due to other environmental threats. The establishment of a fish sanctuary is a way to conserve fish for future generation. A study was conducted to know the impact of the sanctuary on fish biodiversity for six months from August to December 2020. Various Participatory rural appraisal (PRA) tools were used such as Questionnaire interviews, focus group discussion (FGD), Catch monitoring and cross-check interviews were carried out. Data were collected from 50 fishermen using a semi-structured questionnaire interview, Group discussion, and gathering secondary information from different sources. According to the findings, 78 fish species were recorded in the study area where 60 fish species were recorded to be found before establishment of the sanctuary. Baseline production of the sanctuary was 0.58 MT/ha in 2015 which increased to 1.12 MT/ha in 2020 after establishment of the sanctuary. The highest total number of fish species were caught in August (68.45%) and lowest (41.55%) in December in the Chikadubi beel. The dominant fish species in Chikadubi beel was Freshwater shark (Wallago attu) followed by Spotted snakehead (Channa punctatus), Indian river shad (Gadusia chapra) and Jatiputi (Puntius sophore) whereas the least available fish species was Koitor poa (Johnius coitor). Among the total catch comprises different family such Cyprinidae 58.33%, Channidae 16.60%, Bagridae 14.58%, Siluridae 6.25% & Schilbeidae 8.33 % respectively. The outcomes suggest that careful planning, management and regular practices, along with active community participation, can have positive impact on fish sanctuary.
Quadruple Arterial Blood Supply to the Liver: A Rare Variation
Authors: Bello S. S.  , Abdulhameed Aliu 
Published: October 2023

Introduction: Vascular variations in the liver are significant to surgeons in liver transplantations, radiological procedures, laparoscopy and penetrating abdominal injuries. These variations are important in liver transplantation procedure, in addition to being an ideal opportunity for surgical anatomy study, their detailed identification is crucial to the success of the procedure.
Case Report: During a routine cadaveric dissection of the abdomen for medical students at the department of Anatomy Usmanu Danfodiyo University, Sokoto Nigeria. A male adult cadaver with unknown identity and cause of death, was found to have four arterial branches to the liver, one each from the left gastric artery and common hepatic artery, a branch from the gastro-duodenal artery and the hepatic artery.
Conclusion: Detailed knowledge of the variations of hepatic arterial anatomy is of utmost importance to surgeons who perform surgeries in this area, particularly in liver transplantation, since their identification and proper management are critical to the success of the procedure.
Clinical Benefit, Price, and Uptake for Cancer Biosimilars vs Reference Drugs in China
Authors: Luo Xingxian , Du Xin , Li Zhuangqi , Liu Jingwen , Lv Xufeng , Li Haoran , Guo Qixiang , Wang Cen , Xue Xuecai , Le Kaidi , Jiang Xiaomeng , Huang Lin , Yang Yue 
Published: October 2023

ImportanceThe high cost of biologics used to treat cancer has been an increasing burden in the world. In China, the recent approval of cancer biosimilar drugs to resolve this problem is promising, but evidence of clinical benefits, price, and uptake for these drugs is still lacking.ObjectivesTo compare characteristics of pivotal clinical trials in China and other countries for biosimilars of bevacizumab, rituximab, and trastuzumab and investigate the efficacy or effectiveness, safety, and immunogenicity outcomes of cancer biosimilars compared with reference drugs by meta-analysis.Data SourcesFor this systematic review and meta-analysis, PubMed, Embase, the Cochrane Library, and ClinicalTrials.gov were searched for published studies from database inception to February 1, 2023, using the search topics (cancers) AND (biosimilars).Study SelectionRandomized clinical trials and cohort studies that included patients with cancer were included.Data Extraction and SynthesisTwo authors independently extracted the outcome estimates and characteristics for each study. A random-effects meta-analysis was performed to summarize the relative estimates with 95% CIs. This study was performed following the Preferred Reporting Items for Systematic Reviews and Meta-analyses guideline.Main Outcomes and MeasuresClinical trial characteristics were collected for biosimilars of bevacizumab, rituximab, and trastuzumab. The relative estimates of efficacy or effectiveness (objective response rate, progression-free survival, and overall survival), safety, and immunogenicity outcomes were analyzed for biosimilars vs reference drugs. The weighted average price and uptake rate were evaluated for biosimilars relative to their reference drugs between 2015 and 2022.ResultsA total of 39 RCTs (involving 18 791 patients) and 10 cohort studies (involving 1998 patients) were included. The biosimilars of bevacizumab (16 RCTs; risk ratio [RR], 0.97; 95% CI, 0.93-1.01; P = .17), rituximab (12 RCTs; RR, 1.03; 95% CI, 0.98-1.08; P = .70), and trastuzumab (9 RCTs: RR, 1.04; 95% CI, 0.97-1.12; P = .29) met equivalence with reference biologics in regard to the objective response rate. The results summarized from cohort studies were consistent with those from RCTs. In 2022, cancer biosimilars were priced at 69% to 90% of the costs for the reference drugs, and their uptake reached 54% to 83% in China.Conclusions and RelevanceThis systematic review and meta-analysis indicated that cancer biosimilars provided comparable clinical benefits at lower prices compared with reference drugs. These findings suggest the potential feasibility of expediting the transition from reference drugs to biosimilars to benefit more patients with cancer.
Expanding impact of mobile health programs: SAHELI for maternal and child care
Authors: Verma Shresth , Singh Gargi , Mate Aditya , Verma Paritosh , Gorantla Sruthi , Madhiwalla Neha , Hegde Aparna , Thakkar Divy , Jain Manish , Tambe Milind , Taneja Aparna 
Published: October 2023

AbstractUnderserved communities face critical health challenges due to lack of access to timely and reliable information. Nongovernmental organizations are leveraging the widespread use of cellphones to combat these healthcare challenges and spread preventative awareness. The health workers at these organizations reach out individually to beneficiaries; however, such programs still suffer from declining engagement. We have deployed Saheli, a system to efficiently utilize the limited availability of health workers for improving maternal and child health in India. Saheli uses the Restless Multi‐armed Bandit (RMAB) framework to identify beneficiaries for outreach. It is the first deployed application for RMABs in public health, and is already in continuous use by our partner NGO, ARMMAN. We have already reached ∼130K beneficiaries with Saheli, and are on track to serve one million beneficiaries by the end of 2023. This scale and impact has been achieved through multiple innovations in the RMAB model and its development, in preparation of real world data, and in deployment practices; and through careful consideration of responsible AI practices. Specifically, in this paper, we describe our approach to learn from past data to improve the performance of Saheli's RMAB model, the real‐world challenges faced during deployment and adoption of Saheli, and the end‐to‐end pipeline.
Is it necessary to perform measurement‐based patient‐specific quality assurance for online adaptive radiotherapy with Elekta Unity MR‐Linac?
Authors: Xu Yuan , Xia Wenlong , Ren Wenting , Ma Min , Men Kuo , Dai Jianrong 
Published: October 2023

AbstractThis study aimed to investigate the necessity of measurement‐based patient‐specific quality assurance (PSQA) for online adaptive radiotherapy by analyzing measurement‐based PSQA results and calculation‐based 3D independent dose verification results with Elekta Unity MR‐Linac.There are two workflows for Elekta Unity enabled in the treatment planning system: adapt to position (ATP) and adapt to shape (ATS). ATP plans are those which have relatively slighter shifts from reference plans by adjusting beam shapes or weights, whereas ATS plans are the new plans optimized from the beginning with probable re‐contouring targets and organs‐at‐risk. PSQA gamma passing rates were measured using an MR‐compatible ArcCHECK diode array for 78 reference plans and corresponding 208 adaptive plans (129 ATP plans and 79 ATS plans) of Elekta Unity. Subsequently, the relationships between ATP, or ATS plans and reference plans were evaluated separately. The Pearson's r correlation coefficients between ATP or ATS adaptive plans and corresponding reference plans were also characterized using regression analysis. Moreover, the Bland–Altman plot method was used to describe the agreement of PSQA results between ATP or ATS adaptive plans and reference plans. Additionally, Monte Carlo‐based independent dose verification software ArcherQA was used to perform secondary dose check for adaptive plans.For ArcCHECK measurements, the average gamma passing rates (ArcCHECK vs. TPS) of PSQA (3%/2 mm criterion) were 99.51% ± 0.88% and 99.43% ± 0.54% for ATP and ATS plans, respectively, which were higher than the corresponding reference plans 99.34% ± 1.04% (p < 0.05) and 99.20% ± 0.71% (p < 0.05), respectively. The Pearson's r correlation coefficients were 0.720 between ATP and reference plans and 0.300 between ATS and reference plans with ArcCHECK, respectively. Furthermore, >95% of data points of differences between both ATP and ATS plans and reference plans were within ±2σ (standard deviation) of the mean difference between adaptive and reference plans with ArcCHECK measurements. With ArcherQA calculation, the average gamma passing rates (ArcherQA vs. TPS) were 98.23% ± 1.64% and 98.15% ± 1.07% for ATP and ATS adaptive plans, separately.It might be unnecessary to perform measurement‐based PSQA for both ATP and ATS adaptive plans for Unity if the gamma passing rates of both measurements of corresponding reference plans and independent dose verification of adaptive plans have high gamma passing rates. Periodic machine QA and verification of adaptive plans were recommended to ensure treatment safety.
Optimized parametrization of adaptive controllers for enhanced current regulation in grid‐tied converters
Authors: Hollweg Guilherme Vieira , Evald Paulo Jefferson Dias de Oliveira , Mattos Everson , Borin Lucas Cielo , Tambara Rodrigo Varella , Montagner Vinicius Foletto 
Published: October 2023

SummaryGrid‐connected converters play a significant role in renewable energy systems, acting as a crucial interface between the inverter and the electrical grid, often incorporating LCL filters. One of the primary challenges in controlling grid‐injected current is the grid uncertainty, which can have a direct impact on the resonance frequency of the LCL filter. Adaptive controllers are feasible to deal with this kind of situation. However, the setup of these controllers requires an experienced designer. This work proposes a novel approach for parametrization of adaptive controllers, as well as their gain initialization, using particle swarm optimization, considering performance indexes and stability constraints. The proposed approach improves the current tracking performance and avoids relevant overshoots during transient regimes. The experimental results of current regulation in a grid‐tied voltage source inverter with an LCL filter provide compelling evidence for the effectiveness of this method. The optimized control structure exhibits significantly lower regulation errors and demonstrates improved tracking dynamics when compared to non‐optimized control structures.
The Role of Hypoxia and Hypoxia Signaling in Skeletal Muscle Physiology
Authors: Endo Yori , Zhu Christina , Giunta Elena , Guo Cynthia , Koh Daniel J. , Sinha Indranil 
Published: October 2023

AbstractHypoxia and hypoxia signaling play an integral role in regulating skeletal muscle physiology. Environmental hypoxia and tissue hypoxia in muscles cue for their appropriate physiological response and adaptation, and cause an array of cellular and metabolic changes. In addition, muscle stem cells (satellite cells), exist in a hypoxic state, and this intrinsic hypoxic state correlates with their quiescence and stemness. The mechanisms of hypoxia‐mediated regulation of satellite cells and myogenesis are yet to be characterized, and their seemingly contradicting effects reported leave their exact roles somewhat perplexing. This review summarizes the recent findings on the effect of hypoxia and hypoxia signaling on the key aspects of muscle physiology, namely, stem cell maintenance and myogenesis with a particular attention given to distinguish the intrinsic versus local hypoxia in an attempt to better understand their respective regulatory roles and how their relationship affects the overall response. This review further describes their mechanistic links and their possible implications on the relevant pathologies and therapeutics.
Considerations from an International Regulatory and Pharmaceutical Industry (IQ MPS Affiliate) Workshop on the Standardization of Complex In Vitro Models in Drug Development
Authors: Tomlinson Lindsay , Ramsden Diane , Leite Sofia Batista , Beken Sonja , Bonzo Jessica A. , Brown Paul , Candarlioglu Pelin L. , Chan Tom S. , Chen Eugene , Choi Colin K. , David Rhiannon , Delrue Nathalie , Devine Patrick J. , Ford Kevin , Garcia Martha Iveth , Gosset James R. , Hewitt Philip , Homan Kimberly , Irrechukwu Onyi , Kopec Anna K. , Liras Jennifer L. , Mandlekar Sandhya , Raczynski Arek , Sadrieh Nakissa , Sakatis Melanie Z. , Siegel Jeffrey , Sung Kyung , Sunyovszki Ilona , Van Vleet Terry R. , Ekert Jason E. , Hardwick Rhiannon N. 
Published: October 2023

AbstractIn May 2022, there is an International Regulatory and Pharmaceutical Industry (Innovation and Quality [IQ] Microphysiological Systems [MPS] Affiliate) Workshop on the standardization of complex in vitro models (CIVMs) in drug development. This manuscript summarizes the discussions and conclusions of this joint workshop organized and executed by the IQ MPS Affiliate and the United States Food and Drug Administration (FDA). A key objective of the workshop is to facilitate discussions around opportunities and/or needs for standardization of MPS and chart potential pathways to increase model utilization in the context of regulatory decision making. Participation in the workshop included 200 attendees from the FDA, IQ MPS Affiliate, and 26 global regulatory organizations and affiliated parties representing Europe, Japan, and Canada. It is agreed that understanding global perspectives regarding the readiness of CIVM/MPS models for regulatory decision making and potential pathways to gaining acceptance is useful to align on globally. The obstacles are currently too great to develop standards for every context of use (COU). Instead, it is suggested that a more tractable approach may be to think of broadly applicable standards that can be applied regardless of COU and/or organ system. Considerations and next steps for this effort are described.