bluuebunny/crossref_metadata_2025_split huggingface dataset:
A Retrospective Analysis of Long-Term Prophylaxis with Berotralstat in Patients with Hereditary Angioedema and Acquired C1-Inhibitor Deficiency—Real-World Data
Authors: Johnson Felix , Stenzl Anna , Hofauer Benedikt , Heppt Helen , Ebert Eva-Vanessa , Wollenberg Barbara , Lochbaum Robin , Hahn Janina , Greve Jens , Trainotti Susanne 
Published: November 2023

AbstractHereditary angioedema (HAE) and acquired C1-inhibitor deficiency (AAE-C1-INH) are orphan diseases. Berotralstat is a recently licensed long-term prophylaxis (LTP) and the first oral therapy for HAE patients. No approved therapies exist for AAE-C1-INH patients. This study is the first to report real-world clinical data of patients with AAE-C1-INH and HAE who received Berotralstat. All patients treated with Berotralstat were included in this retrospective, bi-centric study. Data was collected from patients’ attack calendars and the angioedema quality of life (AE-QoL) and angioedema control test (AECT) questionnaires before treatment, and at 3, 6, and 12 months after treatment and was then analyzed. Twelve patients were included, 3 patients with AAE-C1-INH, 7 patients with HAE type I, and 2 patients with HAE-nC1-INH. One patient (HAE I) quit treatment. Berotralstat was associated with fewer attacks in all groups. After 6 months of treatment, a median decrease of attacks per month was noted for HAE type I patients (3.3 to 1.5) and AAE-C1-INH patients (2.3 to 1.0). No aerodigestive attacks were noted for AAE-C1-INH patients. For HAE-nC1-INH patients, a mean decrease from 3.8 to 1.0 was noted (3 months). For HAE I patients, the total AE-QoL lowered a mean of 24.1 points after 6 months, for HAE-nC1-HAE patients 8.0 points, and for AAE-C1-INH patients 13.7 points. AECT scores increased for HAE I patients (mean: 7.1), HAE-nC1-INH patients (9.0), and AAE-C1-INH patients (4.2) after 6 months. Patients with HAE, HAE-nC1-INH, and AAE-C1-INH treated with Berotralstat showed reduced angioedema attacks and improved AE-QoL and AECT scores.
Linkages between the concept of nature-based solutions and the notion of landscape
Authors: Sowińska-Świerkosz Barbara , García Joan , Wendling Laura 
Published: November 2023

AbstractAs the effects of Nature-based solutions (NBS) application are usually much broader than only the area under the project implementation, it is necessary to capture the impact on these actions of landscape as well as the influence of landscape type on the NBS effectiveness. The main aim of this study was to detect linkages between the operational of NBS and the landscape dimention, based on a systematic literature review. The results showed the existence of seven linkages: (1, 2) ‘input’ and ‘output’ resulting from the consideration of landscape as a scale of NBS implementation; (3, 4) ‘stimulator’ and ‘inspiration’ based on the contribution of landscape-based management to the implementation of NBS; (5) ‘co-beneficiary’ since the implementation of NBS affects aesthetic dimensions of landscape; (6) ‘tool’ as landscape-based indicators are used to assess the impacts of NBS; and (7) ‘foundation’ as health-supporting landscapes may be considered as a type of NBS action.
Laparoscopic versus open liver resection for intrahepatic cholangiocarcinoma: a systematic review of propensity score-matched studies
Authors: Hu Ya-Fei , Hu Hai-Jie , Ma Wen-Jie , Jin Yan-Wen , Li Fu-Yu 
Published: November 2023

AbstractOutcomes of laparoscopic liver resection (LLR) versus open LR (OLR) for intrahepatic cholangiocarcinoma (ICCA) are heterogeneous. We aimed to compare LLR and OLR for ICCA based on propensity-score-matched (PSM) studies. Two reviewers independently searched the online databases (PubMed, Embase, and Cochrane Library) for PSM studies that compared LLR and OLR for ICCA. The Ottawa–Newcastle Quality Assessment Scale with a cutoff of ≥ 7 was used to define higher-quality literature. Only ‘high-quality’ PSM analyses of the English language that met all our inclusion criteria were considered. A total of ten PSM trials were included in the analyses. Compared with OLR, although the lymph node dissection (LND) (RR = 0.67) and major hepatectomy rates were lower in the LLR group (RR = 0.87), higher R0 resections (RR = 1.05) and lower major complications (Clavien–Dindo grade ≥ III) (RR = 0.72) were also observed in the LLR group. In addition, patients in the LLR group showed less estimated blood loss (MD = − 185.52 ml) and shorter hospital stays as well (MD = − 2.75 days). Further analysis found the overall survival (OS) (HR = 0.91), disease-free survival (DFS) (HR = 0.95), and recurrence-free survival (HR = 0.80) for patients with ICCA after LLR were all comparable to those of OLR. LLR for selected ICCA patients may be technically safe and feasible, providing short-term benefits and achieving oncological efficacy without compromising the long-term survival of the patients.
Viral lumbosacral radiculitis (Elsberg syndrome) in Denmark
Authors: Petersen Pelle Trier , Bodilsen Jacob , Jepsen Micha Phill Grønholm , Larsen Lykke , Storgaard Merete , Hansen Birgitte Rønde , Lüttichau Hans Rudolf , Helweg-Larsen Jannik , Wiese Lothar , Andersen Christian Østergaard , Nielsen Henrik , Brandt Christian Thomas ,   Danish Study Group of Infections of the Brain (DASGIB)
Published: November 2023

Abstract
Purpose
To describe clinical features and outcomes of viral lumbosacral radiculitis (Elsberg syndrome).

Methods
Nationwide population-based cohort study of all adults hospitalised for viral lumbosacral radiculitis at departments of infectious diseases in Denmark from 2015 to 2020.

Results
Twenty-eight patients with viral lumbosacral radiculitis were included (mean annual incidence: 1.2/1,000,000 adults). The median age was 35 years (IQR 27–43), and 22/28 (79%) were female. All patients had urinary retention, with 17/28 (61%) needing a catheter. On admission, at least one sign or symptom of meningitis (headache, neck stiffness, photophobia/hyperacusis) was present in 18/22 (82%). Concurrent genital herpetic lesions were present in 11/24 (46%). The median cerebrospinal fluid leukocyte count was 153 cells/µL (IQR 31–514). Magnetic resonance imaging showed radiculitis/myelitis in 5/19 (26%). The microbiological diagnosis was herpes simplex virus type 2 in 19/28 (68%), varicella-zoster virus in 2/28 (7%), and unidentified in 7/28 (25%). Aciclovir/valaciclovir was administered in 27/28 (96%). At 30 days after discharge, 3/27 (11%) had persistent urinary retention with need of catheter. At 180 days after discharge, moderate disabilities (Glasgow Outcome Scale score of 4) were observed in 5/25 (20%).

Conclusions
Urinary retention resolved within weeks in most patients with viral lumbosacral radiculitis, but moderate disabilities according to the Glasgow Outcome Scale were common at the end of follow-up.
European Tuber melanosporum plantations: adaptation status in Hungary, mycorrhizal level, and first ascocarp detection in two truffle orchards
Authors: Habtemariam Akale Assamere , Cseh Péter , Bratek Zoltán 
Published: November 2023

AbstractTuber melanosporum is one of the most economically important truffle species. Besides harvesting from its natural habitats, this truffle can also be extensively grown through artificial cultivation. However, the natural habitat of T. melanosporum has drastically declined, and the demand for the truffle in society is rapidly increasing. Therefore, enhancing production in truffle orchards by seeking new places for the establishment and regularly monitoring its adaptability might be an effective method for ensuring the sustainable productivity of the species. As a truffle science, recent information is important to further success in the growth of this truffle species. This study reports mycorrhization level and ascocarp production in two truffle plantations in Hungary. The estimated mycorrhization levels of the host plants were 43.36% in Biatorbágy and 42.93% in Jászszentandrás plantations. In March 2020, the 6-year-old and 18-year-old T. melanosporum plantations yielded around 100 g and 980 g of ascocarps, respectively. In general, adaptation of mycorrhizal seedlings in Hungary may become more effective as present management practices improve.
Biogeographic history, egg colouration, and habitat selection in Turdus thrushes (Aves: Turdidae)
Authors: Nagy Jenő , Fulmer Andrew G. , Löki Viktor , Ruiz-Raya Francisco , Hauber Mark E. 
Published: November 2023

AbstractDespite broad interest and recent experimentation, there is no single ecological model accounting for the adaptive significance of the diversity of avian eggshell colouration. The often blue-green eggs of Turdus thrushes are a charismatic example of this, having long captured cultural and scientific attention. Although the biology and evolutionary history of “true” thrushes is well understood, little is known about correlated evolution between shifts in habitat and eggshell pigmentation, and how these shifts map with Turdus biogeography. We applied phylogenetic comparative methods to assess the evolutionary timing of divergence and variation of life history traits and eggshell colouration and maculation presence in the genus. We found that eggshell colour diversified independently on several occasions in the past 11 million years, with much of the variation occurring within the last 4 million years. The majority of Turdus species lay blue-green eggs and also tend to be sedentary and forest-dwelling. Diet generalist species and species which have transitioned to a forest habitat are more likely to lay white eggs (10% of studied species). In turn, lineages in any habitat were more likely to transition to blue-green eggs. We found that variation in egg colour is increased in some clades, of which two lineages radiated in South America and the East Palearctic, in the past 2–4 million years. These findings provide support for the hypothesis that white eggs are more conspicuous to predators in open environments and that multiple, non-mutually exclusive constraints operate on the adaptive function of avian eggshell colour.
Reliability of depleted cement–ground slab with waste granodiorite dust admixture on semi-saturated substrate
Authors: Wyborski Piotr , Kania Tomasz , Kozubal Janusz Vitalis , Zięba Zofia , Mońka Jakub 
Published: November 2023

Abstract
There are many types of pavements for roads. For technical roads, one of the most effective and economically advantageous pavement types is chemically stabilized soil pavement. When designing a pavement made of soil admixed with binders, it is necessary to meet the load-bearing conditions while considering the effects of environmental factors. The aims of this study were to optimize the strength parameters of pavement, minimize negative environmental effects, minimize the carbon footprint, and simultaneously dispose of mineral waste materials from the production of asphalt mixes for roads. After testing the strengths of samples admixed with cement or with reduced cement content and the addition of dust, questions arose as to how both materials affect the reliability of the pavement structure. Samples of soil doped with cement and dust were subjected to reliability analyses. Abaqus software with a three-dimensional subgrade model was used for a comparative analysis. The substrates under soil stabilization slabs were subjected to varying saturation states, which affected their vulnerability. In this study, the changes in the saturation characteristics of the subsoils associated with different types of climatic interactions were simulated. The Darcy–Buckingham law was used to describe the flow of liquids through the subsoil. Pavement reliability calculations were performed for a multidimensional space of random variables. The results served as an interesting starting point for recommendations to decrease the use of energy-intensive materials, increase the reuse of waste, and reduce the effects of the strengthening process on the environment.
A novel technique for solving intuitionistic fuzzy DEA model: an application in Indian agriculture sector
Authors: Mohanta Kshitish Kumar , Sharanappa Deena Sunil 
Published: November 2023

AbstractFuzzy DEA is a performance measurement tool that is used to assess the performance of DMUs in highly uncertain environments. In this article, the Intuitionistic fuzzy DEA (IFDEA) model is proposed based on the triangular intuitionistic fuzzy numbers (TIFNs). The weighted Possibility mean for TIFN is used to compare and rank the TIFN. The weighted possibility mean approach is proposed to solve the IFDEA model, and the IFDEA model is converted into its equivalent crisp DEA model to assess the relative efficiencies of the DMUs. One advantage of the proposed approach is that the attitude of the decision-maker is considered while measuring the efficiency of the DMUs. The weight or risk factor $$\delta \in [0,1]$$

δ
∈
[
0
,
1
]

indicates whether the decision-maker is a risk-taker, neutral, or adverse. The crisp DEA model is a LP problem that is solved by using an existing LP method with different risk factors to determine the efficiency score of the DMUs. The DMUs are ranked based on the overall efficiency score of the DMUs, which is the arithmetic mean of the efficiency scores of the DMUs with different risk factors. Two numerical examples are given here to demonstrate the validity and applicability of the proposed technique and to compare the performance of the DMUs in the proposed approach with the exciting ranking approach and the expected value approach. A case study on the agriculture sector has been conducted in order to evaluate the agricultural performance of Indian states using the IFDEA model. According to the results of the IFDEA model, 15 (53.57%) out of the 28 Indian states were found to be efficient.
Exploring the salience of religious identity on the mental health of the Mauritian adult
Authors: Veerasamy Krishni , Putteeraj Manish , Somanah Jhoti 
Published: November 2023

AbstractReligion is undeniably one of the core components of the Mauritian identity, with religious values and principles woven into the Mauritian fabric. Due to the existing gaps in the research of religion and mental health in the Mauritian community, this study sought to examine the impact of religious identity on the psychological well-being of the typical Mauritian. 276 quantitative responses were retrieved, and 12 participants from the 3 main religious groups in the country were interviewed for an in-depth analysis of their religious identities. Results strongly demonstrated positive links between the 3 dimensions of religious identity and total well-being; religious identity achievement [χ2(1680) = 2228 p < 0.05, Cramer’s V = 0.537]; religious affirmation and belongingness [χ2(1620) = 2041, p < 0.05, Cramer’s V = 0.523], and religious faith and practices [χ2(1620) = 1757, p < 0.05, Cramer’s V = 0.487]. Religious practice strongly associated with emotional stability [χ2(246) = 296.15, p < 0.05, Cramer’s V = 0.432] and happiness [χ2(48) = 73.86, p < 0.05, Cramer’s V = 0.211]. Demographically, educational attainment did not affect religious identification in the Mauritian community. The findings clearly demonstrate the need for an integrative system with ingroup beliefs and traditions embedded into models of recovery for psychological disorders. Mental health professionals should consider alternative approaches, reeling in religion and spiritual dimensions of healing into conventional therapies. The role of religious settings in improving psychological treatment adherence and fostering mental well-being should not be downplayed.
Case history factors and audiological screening outcomes in HEU and HIV unexposed neonates at a district level hospital in Gauteng, South Africa
Authors: Khoza-Shangase Katijah , Nesbitt Julia 
Published: November 2023

AbstractWhile progress has been made in reducing vertical Mother to Child Transmission (MTCT) of HIV, limited research exists on the health needs of HIV-exposed uninfected (HEU) neonates, particularly in the field of audiology. This lack of research and evidence could impact early detection and intervention efforts. This study aimed to establish relationships and compare outcomes between case history factors and audiological screening results in HEU and HIV-unexposed neonates at a district-level hospital in Gauteng, South Africa. A non-experimental quantitative, descriptive, cross-sectional, comparative research design was employed. Data was collected with a sample size of 212 participants (100 HEU, 112 HIV-unexposed neonates) recruited using quota sampling. The hearing screening process involved case history assessment, medical file review, otoscopy, tympanometry testing, Distortion Product Evoked Otoacoustic Emissions (DPOAE), and Automated Auditory Brainstem Response (AABR) measurements. Descriptive and inferential statistics, including measures of central tendency and parametric tests, were used for data analysis. The findings indicated that 43% of HEU neonates exhibited refer findings on DPOAE, and 43% on AABR, compared to 26% and 25% respectively in the HIV-unexposed neonatal group. Therefore, a statistically significant relationship was established when comparing audiological results between the HEU and HIV-unexposed groups. Case history factors such as mode of delivery, birth weight, and Apgar scores were not associated with hearing loss in either group. However, in the HEU group, a higher proportion of participants referred on the overall screening in the maternal Retroviral Disease (RVD) stage IV group, although statistical significance was not established. This study fills an evidence gap regarding HEU neonates and highlights the need to include this vulnerable population in policy and clinical guidelines related to early hearing detection, intervention, and preventive audiology initiatives.
Estimating Years of Life Lost due to COVID-19 over the first two years of the pandemic in Cyprus: comparisons across areas, age, and sex
Authors: Charalampous Periklis , Haagsma Juanita A. , Cuschieri Sarah , Devleesschauwer Brecht , Pires Sara M. , Polinder Suzanne , Wyper Grant M. A. , Hatziyianni Amalia , Pallari Elena 
Published: November 2023

AbstractKnowledge about the extent of the COVID-19 mortality burden is important to inform policy-making decisions. To gain greater insights into the population health impact of COVID-19 mortality, Years of Life Lost (YLL) can be estimated. We aimed to determine YLL linked to COVID-19 over the first two years (March 2020–March 2022) of the pandemic in Cyprus, by areas, and by age and sex. COVID-19 YLL was estimated by multiplying COVID-19 mortality counts by age-conditional life expectancy from the 2019 Global Burden of Disease life table. COVID-19 accounted for 16,704 YLL over the first two years of the pandemic—approximately 18.5 years lost per individual who died due to COVID-19 and 1881 YLL per 100,000 population. YLL per 100,000 was higher among males compared to females (2485 versus 1303 per 100,000) and higher among older than younger individuals. COVID-19 deaths and YLL per 100,000 were higher in high population-dense areas of Cyprus, such as Limassol. Continued evaluations of COVID-19 YLL are needed to inform on the proportionate population impact of COVID-19, over time and across areas of Cyprus.
Assessment of noise pollution of fireworks during Christmas and New Year in the city of Buenos Aires: comparison with a different management strategy applied to the city of Santiago de Chile
Authors: Lombera Esteban N. , Bori Guillermo , Vergara Ramiro O. 
Published: November 2023

AbstractFireworks are widely celebrated worldwide but have raised environmental concerns due to pollutant emissions. This has prompted evolving legislation in many countries, necessitating scientific evidence for policy development. Existing literature mainly focuses on characterizing individual fireworks and quantifying noise variations between festive and non-festive periods. However, no such studies have been conducted in Argentina. This study aims to characterize noise levels generated by fireworks during the 2020 Christmas and New Year celebrations in Buenos Aires. Nine measurement systems were used, obtaining acoustic descriptors reflecting noise levels during these events. Results were compared with typical ambient noise levels in the city and those during the New Year's fireworks display in Santiago de Chile, where public access to individual fireworks is restricted. Findings indicate significant noise level increases during the Christmas and New Year celebrations, supported by the L01 percentile acoustic parameter, more effective in characterizing impulsive events than Equivalent continuous sound pressure level LeqA. Comparing results with Santiago de Chile, noise values in Argentina remained similar within a 1.1 km proximity to the fireworks show, whereas beyond that distance, Chilean residents experienced lower noise levels.
Updip Fluid Flow in the Crust of the Northeastern Noto Peninsula, Japan, Triggered the 2023 Mw 6.2 Suzu Earthquake During Swarm Activity
Authors: Yoshida Keisuke , Uchida Naoki , Matsumoto Yoshiaki , Orimo Masaki , Okada Tomomi , Hirahara Satoshi , Kimura Shuutoku , Hino Ryota 
Published: November 2023

AbstractAn Mw 6.2 earthquake occurred in Suzu, northeastern Noto Peninsula, Japan, on 5 May 2023, followed by many aftershocks. Before this mainshock‐aftershock sequence, an intense earthquake swarm lasted in the vicinity for 2.5 years. Here, we estimated the rupture process of the Mw 6.2 mainshock and relocated >20,000 surrounding small earthquakes. The results show that systematic upward migration occurred via a complex network of faults in the preceding swarm period and that the mainshock rupture was initiated near the shallow end of the swarm earthquakes. The mainshock rupture propagated farther updip, followed by many aftershocks in the shallow extension. Upward fluid movement likely caused systematic upward earthquake migration from a depth of 18–5 km. The present results indicate the importance of monitoring swarm events since large (M > 6) and dangerous earthquakes can occur during such swarms.
Identifying the Variety of Jovian X‐Ray Auroral Structures: Tying the Morphology of X‐Ray Emissions to Associated Magnetospheric Dynamics
Authors: Weigt D. M. , Jackman C. M. , Moral Pombo D. , Badman S. V. , Louis C. K. , Dunn W. R. , McEntee S. C. , Branduardi‐Raymont G. , Grodent D. , Vogt M. F. , Tao C. , Gladstone G. R. , Kraft R. P. , Kurth W. S. , Connerney J. E. P. 
Published: November 2023

AbstractWe define the spatial clustering of X‐rays within Jupiter's northern auroral regions by classifying their distributions into “X‐ray auroral structures.” Using data from Chandra during Juno's main mission observations (24 May 2016 to 8 September 2019), we define five X‐ray structures based on their ionospheric location and calculate the distribution of auroral photons. The morphology and ionospheric location of these structures allow us to explore the possibility of numerous X‐ray auroral magnetospheric drivers. We compare these distributions to Hubble Space Telescope (HST) and Juno (Waves and MAG) data, and a 1D solar wind propagation model to infer the state of Jupiter's magnetosphere. Our results suggest that the five sub‐classes of “X‐ray structures” fall under two broad morphologies: fully polar and low latitude emissions. Visibility modeling of each structure suggests the non‐uniformity of the photon distributions across the Chandra intervals are likely associated with the switching on/off of magnetospheric drivers as opposed to geometrical effects. The combination of ultraviolet (UV) and X‐ray morphological structures is a powerful tool to elucidate the behavior of both electrons and ions and their link to solar wind/magnetospheric conditions in the absence of an upstream solar monitor. Although much work is still needed to progress the use of X‐ray morphology as a diagnostic tool, we set the foundations for future studies to continue this vital research.