bluuebunny/crossref_metadata_2025_split huggingface dataset:
Incremental Diagnostic Value of Right Ventricular Strain Analysis in Arrhythmogenic Right Ventricular Cardiomyopathy
Authors: Dong Zhixiang , Ma Xuan , Wang Jiaxin , Yang Shujuan , Yu Shiqin , Song Yanyan , Tang Yun , Xiang Xiaorui , Yang Kai , Zhao Kankan , Lu Minjie , Chen Xiuyu , Zhao Shihua 
Published: December 2023

Background
Strain analysis is a sensitive method for the assessment of ventricular structural or functional alterations. The authors aimed to determine whether right ventricular (RV) strain parameters can discriminate patients with revised Task Force Criteria–diagnosed arrhythmogenic RV cardiomyopathy (ARVC) incremental to the existing cardiovascular magnetic resonance (CMR) criteria, thus improving the diagnostic yield of CMR in ARVC.

Methods and Results

A total of 74 patients with revised Task Force Criteria–diagnosed ARVC (37 borderline and 37 definite) and 37 controls were retrospectively enrolled for analysis. Using CMR feature tracking, RV global longitudinal (GLS), circumferential, and radial strain of all participants were evaluated. Compared with controls, the study patients demonstrated significantly impaired global biventricular strain in all 3 directions (all
P
<0.001). Receiver operating characteristic curve analysis indicated that RV GLS was the strongest discriminator among all RV strain parameters for the identification of patients with ARVC (area under the curve, 0.92). Using the Youden index, the authors determined RV GLS ≥−19.95% as the diagnostic criterion of ARVC. In patients diagnosed with borderline ARVC according to revised Task Force Criteria but with no or only minor CMR criteria, there were >50% presenting with impaired RV GLS. When both conventional criteria and RV GLS were considered together, this new diagnostic method demonstrated an overall diagnostic accuracy of 90%. The likelihood ratio test showed a significant incremental diagnostic value of RV GLS (
P
=0.02) over the existing CMR major criteria.

Conclusions
The current study showed an improved diagnostic accuracy when both RV GLS and the existing CMR criteria were considered together, especially for patients with borderline diagnosis, suggesting the incremental value of strain analysis to the initial assessment of ARVC.
Plasma Calprotectin Levels Associate With New‐Onset Hypertension in the General Population: A Prospective Cohort Study
Authors: Bourgonje Arno R. , Bourgonje Martin F. , la Bastide‐van Gemert Sacha , Nilsen Tom , Hidden Clara , Gansevoort Ron T. , Bakker Stephan J. L. , Mulder Douwe J. , Dullaart Robin P. F. , Abdulle Amaal E. , van Goor Harry 
Published: December 2023

Background
Low‐grade systemic inflammation is a relevant pathogenic mechanism underlying the development of hypertension. In this study, we hypothesized that plasma calprotectin levels, as a biomarker of neutrophil‐mediated inflammation, is associated with developing new‐onset hypertension in the general population.

Methods and Results

Plasma calprotectin levels were determined in 3524 participants who participated in the PREVEND (Prevention of Renal and Vascular End‐Stage Disease) study, a prospective population‐based cohort study. Plasma calprotectin levels were studied for associations with the risk of new‐onset hypertension, defined as systolic blood pressure of at least 140 mm Hg, diastolic blood pressure of at least 90 mm Hg, or the first recorded use of antihypertensives. Participants with hypertension at baseline were excluded. Median plasma calprotectin levels were 0.48 (0.34–0.66) mg/L, and median systolic blood pressure was 117 (109–126) mm Hg. Plasma calprotectin levels were significantly associated with the risk of new‐onset hypertension (hazard ratio [HR], per doubling 1.30 [95% CI, 1.21–1.41];
P
<0.001), also after adjustment for age and sex (HR, 1.26 [95% CI, 1.16–1.37];
P
<0.001), but not after additional adjustment for potentially confounding factors, including baseline systolic blood pressure (HR, 1.00 [95% CI, 0.90–1.11];
P
=0.996). Stratified analyses showed significant effect modification by sex (
P
interaction
=0.023) and urinary albumin excretion (
P
interaction
=0.004), with higher HRs in men (compared with women) and in individuals with higher urinary albumin excretion (>9.3 mg per 24 hours) compared with lower urinary albumin excretion (≤9.3 mg per 24 hours).

Conclusions
Higher plasma calprotectin levels are associated with an increased risk of new‐onset hypertension in the general population. This association is dependent on baseline systolic blood pressure and is particularly prominent in men compared with women.
Transcatheter Closure or Surgery for Symptomatic Paravalvular Leaks: The Multicenter KISS Registry
Authors: Güner Ahmet , Kırma Cevat , Ertürk Mehmet , Türkmen Muhsin , Alıcı Gökhan , Karabay Can Yücel , Uzun Fatih , Kılıçgedik Alev , Gündüz Sabahattin , Güler Gamze Babur , Kalkan Ali Kemal , Özkan Birol , Sarı Münevver , Gürsoy Mustafa Ozan , Tekin Meltem , Yıldız Mustafa , Can Fatma , Kırali Kaan , Fedakar Ali , Sarıkaya Sabit , Aydın Ünal , Kahraman Serkan , İyigün Taner , Aksüt Mehmet , Karpuzoğlu Eren , Çiloğlu Koray , Sungur Mustafa Azmi , Tanboğa İbrahim Halil , Özkan Mehmet 
Published: December 2023

Background
The optimal treatment of symptomatic paravalvular leak (PVL) remains controversial between transcatheter closure (TC) and surgery. This large‐scale study aimed to retrospectively evaluate the long‐term outcomes of the patients who underwent reoperation or TC of PVLs.

Methods and Results

A total of 335 (men, 209 [62.4%]; mean age, 58.15±12.77 years) patients who underwent treatment of PVL at 3 tertiary centers between January 2002 and December 2021 were included. Echocardiographic features, procedure details, and in‐hospital or long‐term outcomes were assessed. The primary end point was defined as the all‐cause death during follow‐up. The regression models were adjusted by applying the inverse probability weighted approach to reduce treatment selection bias. The initial management strategy was TC in 171 (51%) patients and surgery in 164 (49%) cases. Three hundred cases (89.6%) had mitral PVL, and 35 (10.4%) had aortic PVL. The mean left ventricular ejection fraction was 52.03±10.79%. Technical (78.9 versus 76.2%;
P
=0.549) and procedural success (73.7 versus 65.2%;
P
=0.093) were similar between both groups. In both univariate and multivariable logistic regression analysis, the in‐hospital mortality rate in the overall population was significantly higher (15.9 versus 4.7%) in the surgery group compared with the TC group (unadjusted odds ratio, 3.13 [95% CI, 1.75–5.88];
P
=0.001; and adjusted odds ratio (inverse probability‐weighted), 4.55 [95% CI, 2.27–10.0];
P
<0.001). However, the long‐term mortality rate in the overall population did not differ between the surgery group and the TC group (unadjusted hazard ratio [HR], 0.86 [95% CI, 0.59–1.25];
P
=0.435; and adjusted HR (inverse probability‐weighted), 1.11 [95% CI, 0.67–1.81];
P
=0.679).

Conclusions
The current data suggest that percutaneous closure of PVL was associated with lower early and comparable long‐term mortality rates compared with surgery.
Naked in the Eyes of the Law
Authors: Kuzmicz Maksymilian M. 
Published: December 2023

Abstract
This paper conducts a legal analysis of the concept of nudity in the context of innovative technologies in selected Europeans jurisdictions. The laws of Poland, Ireland, and the European Union are examined and compared in terms of their approach to the protection of nudity. The research finds that while there are similarities in the criminal laws of Poland and Ireland, there are also notable differences in the understanding of nudity. Additionally, the proposed EU Directive on combating violence against women and domestic violence is examined in relation to the non-consensual distribution of intimate and manipulated images. The study concludes by recommending further research to clarify the legal definition of nudity, and to address the concerns of different individuals and groups with varying sensitivity towards nudity.
The Place of the Qurʾān and Islamic Theology in Ḥayy ibn Yaqẓān and its Early English Receptions: A Study in Textual Citation and Excision
Authors: Gallien Claire 
Published: December 2023

Abstract
This article on the place of the Qurʾān and Islamic theology in Ḥayy ibn Yaqẓān constitutes a study in textual citation and excision articulated in two main parts. The first part of the article studies the interconnections between philosophy and theology in Ibn Ṭufayl’s (d. 581/1185) life and the references to the Qurʾān and to Islamic theology in his Risālat Ḥayy ibn Yaqẓān. In the second part, I track the engagement with the Qurʾān and Islamic theology in the early-modern Latin and English variants of the tale. The article provides a detailed study of the Qurʾanic passages in translation, and reflects on practices of citation, excision and significant paratextual reorganisations. The article argues that the case is less one where the Qurʾān and Islamic theology are excised from the tale and vanish from view, than one where the tale is ‘de-Islamised’ so that it can serve intra-Christian and orientalist interests. The issue resides in making the Qurʾān and Islam epistemically dispensable and in disabling them as hermeneutic interlocutors to be reckoned with in a theological and philosophical debate.
Resilience, immunity, L2-teacher grit, and reflective teaching in language instruction: in service classes matters
Authors: Ismail Sayed M. , Nikpoo Iman 
Published: December 2023

AbstractA professional training or staff development endeavor is known as an in-service program. During these programs, professionals get training and have the opportunity to discuss their work with others who are in their peer group. In the context of the field of education, the term "in-service classes" refers to the process by which instructors participate in additional education or training over the duration of their job in order to maintain or improve their level of professional knowledge, abilities, and practices. In spite of the fact that publicizing in-service programs for language teachers is of utmost significance, not enough focus has been placed on elaborating how they contribute to teacher-related traits. In this study, an effort was made to compare and contrast the outcomes and progress of language instructors who attended or did not attend an in-service program, as well as the effects of this decision on the teachers' resilience, immunity, L2-teacher grit, and reflective teaching. This research was of a quasi-experimental type, and it included participation from 103 English as a Foreign Language (EFL) teachers. During this research project, members of the first group, known as the control group, were not required to attend any in-service courses, whereas members of the second group, known as the experimental group, were. According to the findings of the MANOVA, EFL teachers who participated in in-service training courses had a significantly better level of resilience, immunity, L2-teacher grit, and reflectivity. It is hoped that the outcomes of this study will shed light on the significant contributions offered by in-service training programs and open up new avenues for the mental well-being of EFL teachers.
Etlingera elatior Compounds as Anticancer Agents of Breast Cancer Through Inhibition of Progesterone Receptor: An In Silico Study
Authors: Afladhanti Putri Mahirah , Hamzah Haidar Ali , Romadhan Muhammad Despriansyah , Putri Safa Nabila , Angelica Ellen Callista , Theodorus Theodorus 
Published: December 2023

Breast cancer is the leading cause of cancer-related death in women globally. Progesterone receptor (PR) is known as the prime example of receptors amenable to targeted breast cancer drug therapy. Etlingera elatior is an herbal plant that has been renowned to have anticancer effect. This study aimed to identify the potential compounds derived from Etlingera elatior as anticancer agents of PR in breast cancer using molecular docking method. This study used fifteen compounds from Etlingera elatior along with lonaprisan as the comparative drug. The PR was downloaded from RCSB, whereas compounds and lonaprisan were from Pubchem. The drug-likeness test based on Lipinski’s rule of five was conducted using SwissADME. Toxicity analysis using admetSAR 2.0 was used to predict toxicological profile of the compounds. Compounds and lonaprisan were docked on PR using AutoDock tools 1.5.6 and AutoDock Vina 1.1.2. Molecular interactions were visualized by Discovery Studio v16. A total of nine compounds met the criteria as drugs based on drug-likeness and toxicity tests. All nine compounds except caffeic acid and vanillic acid had higher binding affinities on PR compared with lonaprisan. Ergosterol peroxide exhibited the highest binding affinity on PR with values of -9.8 kcal/mol. Moreover, ergosterol peroxide-PR interaction had thirteen hydrophobic bonds and a hydrogen bond with amino acid residues were found in the active site of PR. Most of the compounds found in Etlingera elatior have the potential to be anticancer agents of PR in breast cancer with ergosterol peroxide being the most potential compound. Further in vitro and in vivo research are needed.Keywords: breast cancer, ergosterol peroxide, Etlingera elatior, progesterone receptor, in silico.
Advances in ferroptosis of cancer therapy
Authors: Dong Ying , Xu Chaojie , Guo Jinli , Liu Yuchen 
Published: December 2023

Abstract
Ferroptosis is an iron-dependent mode of programmed cell death characterized by Reactive Oxygen Species (ROS) accumulation lipid peroxidation and glutathione depletion. It is a novel form of cell death different from apoptosis and necrosis. Because of its unique mode of cell death, it has attracted a large number of research reports from the oncology community. Changes in iron ions and accumulation of lipid peroxides have confirmed the correlation between ferroptosis and tumors, and thus ferroptosis can be considered to have a great oncological therapeutic potential. This paper brings to light the significance of metabolic pathways and key genes like System Xc-/Glutathione Peroxidase 4 (GPX4), Membrane-bound O-acyltransferases 1 (MBOAT1) and Membrane-bound O-acyltransferases 2 (MBOAT2) in modulating ferroptosis in cancer cells. The susceptibility of cancer cells to ferroptosis, influenced by their high levels of reactive oxygen species and specific mutation profiles, is analyzed, suggesting new avenues for enhancing the effectiveness of established cancer treatments. In this review, we address the current understanding of ferroptosis induction and ferroptosis defense mechanisms, briefly describe the role and mechanisms of ferroptosis in tumor suppression, and discuss therapeutic strategies for targeting ferroptosis caused by tumors.
THE EFFECT OF LUMBAR STABILIZATION EXERCISES ON CHRONIC LOW BACK PAIN PATIENTS
Authors: BARUT Kayra , TAŞTABAN Engin , ŞENDUR Ömer 
Published: December 2023

Objective
The aim of this study is to investigate the effect
of lumbar stabilization exercises (LSE) on pain,
functional capacity, quality of life, and balance in
patients with chronic low back pain (CLBP), and also
to evaluate the effect on the cross-sectional area of
the lumbar multifidus muscle.
Material and Method
Sixty-six patients with CLBP were enrolled,
randomized, and divided into two groups. LSE,
transcutaneous electrical nerve stimulation (TENS),
and hot pack treatments were performed in Group
1 (n=28). In Group 2 (n=37), TENS and hot pack
treatments were performed only. Pre and 8-week
post-treatment assessments were made. Visual
Analog Scale (VAS) was used to evaluate pain.
Modified Oswestry Disability Index (ODI) and Roland
Morris Disability Questionnaire (RMDQ) were used
to evaluate the functional disability. Short Form-36
(SF-36) was used to measure the quality of life. In
the assessment of balance, a Tetrax® posturography
device (Sunlight Medical Ltd, Israel) was used and fall
index (FI) was calculated. The cross-sectional area of
multifidus muscles was measured by ultrasonography.
Results
Significant improvements regarding the crosssectional
area of multifidus musclesand subparameters
of SF-36 named physical role, pain,
mental health, and energy/vitality were determined in
Group 1 compared to Group 2 (p˂0.05). No significant
difference was present between the groups regarding
FI, VAS score, RMDQ, ODI, and balance.
Conclusion
Lumbar stabilization exercises in patients with chronic
low back pain multifidus positively affects crosssectional
area and quality of life. For our sample,
the addition of lumbar stabilization exercises to
the conventional physical therapy program does
not provides an additional contribution in terms of
balance, pain and disability.
Students’ collaboration and communication skills with problem-based learning model
Authors: Putri Cynthia Nora Dwi , Sedyati Retna Ngesti , Zulianto Mukhamad 
Published: December 2023

Abstrak: Penelitian ini bertujuan untuk mengetahui tingkat keterampilan kolaborasi dan komunikasi peserta didik dengan model Problem Based Learning (PBL). Subjek penelitian ini adalah 77 peserta didik yang dipilih dengan teknik purposive sampling. Penelitian ini menggunakan jenis penelitian deskriptif kuantitatif. Pengukuran data menggunakan lembar observasi yang dianalisis dengan persentase. Berdasarkan hasil penelitian keterampilan kolaborasi dan komunikasi dengan model Problem Based Learning (PBL) menunjukkan bahwa secara keseluruhan peserta didik kelas XI IPS SMAN di Banyuwangi sudah mencerminkan keterampilan kolaborasi dan komunikasi. Persentase keterampilan kolaborasi peserta didik kelas XI IPS SMAN di Banyuwangi sebesar 60,5 persen yang termasuk dalam kategori “cukup”. Selanjutnya persentase keterampilan komunikasi peserta didik kelas XI IPS SMAN di Banyuwangi sebesar 53,2 persen yang termasuk dalam kategori “cukup”. Hasil dari keterampilan kolaborasi dan komunikasi peserta didik ini menyatakan bahwa setiap peserta didik telah menunjukkan sikap dari keterampilan-keterampilan tersebut.Abstract: This study aims to determine the level of collaboration and communication skills of students with problem-based learning models. The sample of this research was 77 students which were selected by purposive sampling technique. This research uses a type of quantitative descriptive research. Measurement of data using observation sheets were analyzed by calculating the average value of the percentage. Based on the results of research on collaboration and communication skills with the Problem Based Learning (PBL) learning model, it shows that overall the students of class XI Social Sciences at Senior High School in Banyuwangi already reflect collaboration and communication skills. The percentage of collaboration skills of class XI Social students at Senior High School in Banyuwangi is 60.5 percent, which is in the "enough" category. Furthermore, the percentage of communication skills of class XI Social students at Senior High School in Banyuwangi is 53.2 percent, which is in the "enough" category. The results of these students' collaboration and communication skills state that each student has shown an attitude of these skills.
The SAMR model for the development of learning device innovations in the subject of applying electronic circuits
Authors: Wahyudi Rykha Avadian , Leksono Ibut Priono , Rohman Ujang 
Published: December 2023

Abstrak: Pengembangan dan penelitian ini menghasilkan perangkatapembelajaran dengan model SAMR (substitution, augmentation, modification, redefinition) untuk mengintegasikanateknologi agar pembelajaranalebih inovatif danakreatif serta meningkatkan pemahaman siswa. Prosedur pengembangan perangkat pembelajaran menggunakan metode pengembangan research and development (R&D) dan pendekatan model SAMR. Teknik pengumpulanadata dilakukan dengan observasiadan angket. Tahap pengujianakelayakan dilakukanaoleh ahli media, ahli desain, ahli materi, temanasejawat dan siswa. Hasil penilaian kelayakan ahli desain diperoleh prosentase 95,5 (valid). Ahli materiadiperoleh prosentase 93,8 (valid). Ahli media diperoleh prosentase 83,8 (valid). Uji kepraktisan oleh teman sejawat diperoleh prosentase 91,7 (baik). Hasil respon terhadap produk di kelompok kecil diperoleh prosentase 98,9 (baik) dan uji coba kelompok besar diperoleh prosentasea97,5 (baik). Hasil data dan analisis penelitian, disimpulkan bahwa pengembangan perangkat pembelajaran penerapan rangkaian elektronika dengan model SAMR kelas XI memudahkan siswa dan guru berkolaborasi mencapai tujuan pembelajaran dan mengembangkan kreatifitas dan inovasi siswa dengan mengintegrasikan teknologi serta dapat diterapkan dalam pembelajaran lainnya.Abstract: By incorporating technology, this Research and Development creates learning aids that use the SAMR (substitution, augmentation, modification, redefinition) model to make learning more original and creative while improving student's knowledge. The SAMR model approach and the Research and Development (R&D) method were used in the process of creating learning tools. Questionnaires and observation were used as data-collecting tools. Media specialists, design experts, material experts, coworkers, and students participated in the feasibility testing stage. A percentage of 95.5 (valid) was attained in the design expert feasibility evaluation results. Experts in material score 93.8 (valid). A valid percentage of 83.8 was given by media professionals. Colleagues' practicality test scored 91.7 out of 100, which is good. The results of the response to the product in the small group obtained a percentage of 98.9 (good), and in large group trials, it was 97.5 (good). The results of the research data and analysis concluded that the development of learning tools applying electronic circuits using the class XI SAMR model makes it easier for students and teachers to collaborate in achieving learning goals and develops student creativity and innovation by integrating technology and can be applied in other learning.