bluuebunny/crossref_metadata_2025_split huggingface dataset:
One‐Step Preparation of Ph‐Sensitive and Antibacterial Calcium Alginate Fibers: In Situ Reduction Method and Original Solution Dyeing
Authors: Hu Jin‐jing , Sun Zeng‐hui , Wu Zi‐wei , Tu Chao , Cui Li , Tan Yao‐jun 
Published: December 2023

AbstractCalcium alginate fiber has become an ideal raw material for wound dressing preparation due to its excellent moisture absorption and biological compatibility. There are still some problems such as bacterial contamination of wounds and difficult observation of wound healing in the actual use process. To avoid bacterial contamination of the wound and visually observe the wound healing situation, a calcium alginate fiber with pH‐responsive and antibacterial properties has been developed by the facile and eco‐friendly one‐step method. In order to make the calcium alginate fiber can be used intelligently to continuously monitor wound changeable pH, the fiber is originally solution dyed by alizarin dye. And the antibacterial property of this calcium alginate fiber is mainly from silver nanoparticles (AgNPs) which are in situ reduced by alginate in the spinning solution. This one‐step wet spinning method can avoid the subsequent complicated process required for calcium alginate fiber functionalization while ensuring the material properties. Owing to the existence of AgNPs, the calcium alginate fiber prepared has a significant antibacterial effect on two kinds of gram bacteria. Therefore, this calcium alginate fiber exhibits good pH‐responsive and antibacterial properties performance and is an improvement upon the current flexible pH sensor to indicate wound healing.
Set that record straight! Cardinal line orientations in music album artwork boost market performance and music consumption
Authors: Joye Yannick , Fennis Bob M. 
Published: December 2023

AbstractIn three studies, we examine the effect of music album artwork on album market performance and music consumption. Based on the perceptual preference for visual stimuli with cardinal (orthogonal) over oblique (tilted) line/edge orientations (a phenomenon known as the “oblique effect”), albums with a predominance of cardinal line/edge orientations in their artwork should perform better than albums with more oblique artwork, as indicated by the albums' market performance and consumers' listening behavior. Study 1, using secondary data, shows that the cardinality of album artwork is a positive predictor of the cover's esthetic appeal and of market performance as evinced by its position in the US charts, expert ratings of the album, and the number of weeks the album remained in the US charts. Studies 2 and 3 use experiments to show that consumers listen longer to music when album artwork is relatively more cardinal than oblique. These studies also explore whether the effect is mediated by higher esthetic appreciation of cardinal (vs. oblique) album artwork in turn affecting song liking. Overall, these findings underscore the importance of visual preferences in packaging design for music consumption.
An Intrinsic Self‐Healable, Anti‐Freezable and Ionically Conductive Hydrogel for Soft Ionotronics Induced by Imidazolyl Cross‐Linker Molecules Anchored with Dynamic Disulfide Bonds
Authors: Liao Haiyang , Su Jiayi , Han Jieling , Xiao Tieming , Sun Xiao , Cui Guixin , Duan Xiaofei , Shi Pu 
Published: December 2023

AbstractHydrogels are ideal materials for flexible electronic devices based on their smooth ion channels and considerable mechanical flexibility. A substantial volume of aqueous solution is required to enable the smooth flow of ions, resulting in the agony of low‐temperature freezing; besides, long‐term exposure to bending/tensile tress triggers fatigue issues. Therefore, it is a great challenge to prepare hydrogels with both freeze‐resistance and long‐term durability. Herein, a polyacrylic acid‐based hydrogel with both hydrophobic interaction and dynamic reversible covalent bonding cross‐linking networks is preparing (DC‐hydrogel) by polymerizing a bi‐functional imidazole‐type ionic liquid monomer with integrated disulfide and alkene bonds (DS/DB‐IL) and an octadecyl methacrylate, achieving self‐healing. The DS/DB‐IL anchored into the polymer backbone has a high affinity with water, reducing the freezing point of water, while the DS/DB‐IL with free ions provides superior ionic conductivity to the DC‐hydrogel. The polyacrylic acid with abundant carboxyl gives hydrogel good self‐adhesiveness to different substrates. Ionotronics with resistance‐type sensors with stable output performance are fabricated and explored its application to joint motion and health information. Moreover, hydrogel‐based sensing arrays with high resolution and accuracy are fabricated to identify 2D distribution of stress. The hydrogels have great promise for various ionotronics in many fields.
K‐band CMOS voltage‐controlled oscillator using switched self‐biasing technique
Authors: Son Hyeon Jin , Shin Dong‐Jun , Choi Ui‐Gyu , Yang Jong‐Ryul 
Published: December 2023

AbstractA complementary metal oxide semiconductor (CMOS) voltage‐controlled oscillator (VCO) using a tail current source modulated with the output frequency is presented to achieve low phase noise with low power consumption at the K‐band. Differentially modulated current sources, which reduce flicker noise by the feedback of the VCO outputs, contribute to an overall reduction in the phase noise of the VCO using the electromagnetic‐based fully symmetrical design. The proposed LC VCO with a 3‐bit switched capacitor bank for a wide tuning range was fabricated on the size of 0.4 × 0.57 mm2 using a 65‐nm CMOS process. The measurement results of the proposed VCO showed a frequency tuning range from 22.57 to 25.3 GHz, and a phase noise of −108.48 dBc/Hz at a 1‐MHz offset frequency with a power consumption of 8.27 mW at a supply voltage of 1.2 V. The calculated figure of merit (FoM) and FoM with the tuning range were −186.48 and −187.67 dBc/Hz, respectively.
Proof‐of‐concept of a data‐driven approach to estimate the associations of comorbid mental and physical disorders with global health‐related disability
Authors: de Vries Ymkje Anna , Alonso Jordi , Chatterji Somnath , de Jonge Peter , Lokkerbol Joran , McGrath John J. , Petukhova Maria V. , Sampson Nancy A. , Sverdrup Erik , Vigo Daniel V. , Wager Stefan , Al‐Hamzawi Ali , Borges Guilherme , Bruffaerts Ronny , Bunting Brendan , Chardoul Stephanie , Karam Elie G. , Kiejna Andrzej , Kovess‐Masfety Viviane , Navarro‐Mateu Fernando , Ojagbemi Akin , Piazza Marina , Posada‐Villa José , Sasu Carmen , Scott Kate M. , Tachimori Hisateru , Have Margreet Ten , Torres Yolanda , Viana Maria Carmen , Zamparini Manuel , Zarkov Zahari , Kessler Ronald C. ,   World Mental Health Survey Collaborators
Published: December 2023

AbstractObjectiveThe standard method of generating disorder‐specific disability scores has lay raters make rankings between pairs of disorders based on brief disorder vignettes. This method introduces bias due to differential rater knowledge of disorders and inability to disentangle the disability due to disorders from the disability due to comorbidities.MethodsWe propose an alternative, data‐driven, method of generating disorder‐specific disability scores that assesses disorders in a sample of individuals either from population medical registry data or population survey self‐reports and uses Generalized Random Forests (GRF) to predict global (rather than disorder‐specific) disability assessed by clinician ratings or by survey respondent self‐reports. This method also provides a principled basis for studying patterns and predictors of heterogeneity in disorder‐specific disability. We illustrate this method by analyzing data for 16 disorders assessed in the World Mental Health Surveys (n = 53,645).ResultsAdjustments for comorbidity decreased estimates of disorder‐specific disability substantially. Estimates were generally somewhat higher with GRF than conventional multivariable regression models. Heterogeneity was nonsignificant.ConclusionsThe results show clearly that the proposed approach is practical, and that adjustment is needed for comorbidities to obtain accurate estimates of disorder‐specific disability. Expansion to a wider range of disorders would likely find more evidence for heterogeneity.
Training factors that influence electrodiagnostic medicine knowledge
Authors: Robinson Lawrence R. 
Published: December 2023

AbstractIntroduction/AimsSelf‐assessment examinations (SAEs) help trainees assess their progress in education. SAEs also provide feedback to training programs as to how factors in training influence examination performance. This study's goal was to examine the relationship between the number of months of training in electrodiagnostic (EDx) medicine, the number of EDx studies during training, and scores on the American Association of Neuromuscular and Electrodiagnostic Medicine SAE.MethodsThis was a retrospective study of the 2023 AANEM‐SAE results. In addition to the examination score, participants were asked approximately how many EDx studies they performed in training and how many months of training they had completed. Analysis included correlation of the examination scores with months of training as well as number of EDx studies. In addition, a multivariate linear regression model was developed.ResultsA total of 756 participants completed the proctored examination in May 2023. Examination score was moderately and positively correlated with the number of months of training (Pearson r = .5; p < .001) as well as the number of EDx studies during training (Pearson r = .55; p < .001). Scores steadily improved with additional months of training, but leveled off after 300–400 EDx studies. Regression analysis indicated that higher numbers of EDx studies were correlated with a higher examination score even after accounting for the number of months of study.DiscussionWe believe that a greater number of months of training is associated with better performance on the AANEM‐SAE and that greatest improvement in examination performance occurs during the first 300–400 EDx studies.
Relapses in early‐stage follicular lymphoma frequently develop via a divergent evolution from their clonally related precursor cells
Authors: Makker Jasmine , Wotherspoon Andrew , Tzioni Maria‐Myrsini , Chen Zi , Guo Sarah , Jiang Dan , Casa Calogero , Cucco Francesco , Du Ming‐Qing 
Published: December 2023

AbstractFollicular lymphoma (FL) develops through a stepwise acquisition of cooperative genetic changes with t(14;18)(q32;q21)/IGH::BCL2 occurring early at the pre‐B stage of B‐cell development. Patients with FL typically show an indolent clinical course, remitting and relapsing with the eventual development of resistance to treatments. Interestingly, the majority of transformed FL do not progress directly from FL but originate from their clonally related lymphoma precursor (CLP) cells. To examine whether such divergent tumour evolution also underpins the relapses in patients with early‐stage FL, we investigated by targeted next‐generation sequencing 13 cases (stage I = 9, stage II = 4), who showed complete remission (mean: 5 years; range: 1–11.5 years) following local radiotherapy but subsequently relapsed (≥2 in 5). A clonal relationship between the diagnostic FL and relapses was confirmed in 11 cases. In six cases, common and distinct variants were seen between the paired diagnostic and relapsed lymphomas, indicating their divergent evolution from a CLP. In two cases, different B‐cell clones were involved in the diagnostic and relapsed lymphomas, including one case involving two different BCL2 translocations. In the remaining five cases, the relapsed lymphoma developed via a linear progression (n = 4) or a mixed evolutionary path (n = 1). These findings may bear important implications in the routine diagnosis and management of relapsed FL. © 2023 The Authors. The Journal of Pathology published by John Wiley & Sons Ltd on behalf of The Pathological Society of Great Britain and Ireland.
Factors associated with the preparedness for bereavement in families of patients with cancer: A secondary analysis of a nationwide bereaved family survey
Authors: Matsuzaka Sakiko , Ohba Akiho , Masukawa Kento , Aoyama Maho , Morita Tatsuya , Kizawa Yoshiyuki , Tsuneto Satoru , Shima Yasuo , Miyashita Mitsunori 
Published: December 2023

AbstractObjectivesInsufficient preparedness for bereavement can affect a family's psychological health status after bereavement. However, factors associated with preparedness remain unclear. This study aimed to identify factors associated with preparedness for bereavement in families of patients with cancer.MethodsWe conducted a secondary analysis of a nationwide bereaved family survey in Japan, analyzing data from 9123 family members of patients with cancer. Logistic regression analysis was conducted to explore how sociodemographic factors, health status, and perceived care for patients and families were associated with preparedness for bereavement.ResultsOf the 9123 families, 1338 (15.1%) were not prepared for bereavement. Factors associated with insufficient preparedness for bereavement (all p < 0.001) were found as follows: patients' spouses (OR = 2.54), receiving care in acute hospitals (OR = 1.83), worse psychological health status during caregiving (OR = 2.13), lower social support for family members (OR = 1.90), wrong patients' awareness of medical condition from family's perspective (OR = 1.75–2.12), family preference of more aggressive treatment rather than palliative care (OR = 1.71) or not sure (OR = 2.31), not wanting to know information about the patient's prognosis (OR = 1.64–1.77), end‐of‐life discussion with physician 1 month before patient's death (OR = 1.45), and late or early end‐of‐life discussions with physician and family (OR = 1.78–1.95).ConclusionsThis study's results might assist clinicians in assessing and identifying families who are not prepared for bereavement; however, preparedness for bereavement may have been associated with other factors.
Influence of high temperature during tensile test for stainless steel using acoustic emission
Authors: Mohammad Mazian , Othman Abdul Rahim , Ismail Mohd Faisal 
Published: December 2023

AbstractThis paper explores the application of acoustic emission (AE) monitoring in mechanical and materials studies, specifically focusing on the detection of plastic deformation, fracture, and crack growth. However, the influence of high temperature on AE signals and its effects on mechanical properties are not fully understood due to the limitations of sensors in high‐temperature environments. To address this gap, the study investigates the impact of high temperatures on the mechanical properties of stainless steel SS304 using AE techniques during tensile testing. Two temperature conditions were tested: 600 and 700°C. AE sensors connected to specimens captured AE activity using a designated waveguide, and a Continuous Creep Monitoring Instrument (CCMi) recorded the responses. Sensitivity testing using the pencil‐lead break (PLB) technique ensured the sensor's capability. The proposed frequency‐based analysis method, fast Fourier transform amplitude (FFTA) analysis, was employed to effectively analyze the AE signals. The results revealed significant AE features and frequency distributions associated with elastic deformation, plastic deformation, and fracture regions. These findings establish a foundation for utilizing AE techniques in crack detection and monitoring under high‐temperature loading, contributing to equipment reliability and structural integrity.
Analysis of colloidal activated carbon alternatives for in situ remediation of a large PFAS plume and source area
Authors: Carey Grant R. , Anderson Richard H. , Van Geel Paul , McGregor Rick , Soderberg Keir , Danko Anthony , Hakimabadi Seyfollah Gilak , Pham Anh Le‐Tuan , Rebeiro‐Tunstall Mia 
Published: December 2023

AbstractThis study evaluated optimal locations for in situ remediation of per‐ and poly‐fluoroalkyl substances (PFAS) in groundwater with colloidal activated carbon (CAC). New Freundlich isotherms for PFAS adsorption to CAC were estimated to illustrate the effect of competitive adsorption with dissolved organic carbon and other PFAS in a groundwater sample. A hypothetical model scenario was constructed based on source area characteristics similar to a site impacted by aqueous film forming foam in South Dakota. Modeling indicates that, even with high PFAS concentrations, CAC would still be capable of maintaining concentrations below proposed maximum contaminant levels in the adsorption zone for at least 30–40 years. Two‐dimensional areal modeling indicates that the future breakthrough of PFAS is likely to occur in the localized core of the plume, and that the corresponding future reinjection of CAC will only need to be conducted over a smaller portion of the original injection footprint. The benefits of implementing a phased remedial approach at PFAS sites are discussed. Source area and mid‐plume CAC treatments are shown to be ineffective at attenuating PFAS concentrations at the downgradient property boundary within a reasonable timeframe when PFAS travel time is relatively slow. Among the CAC alternatives evaluated here, a downgradient CAC permeable reactive barrier has the best performance with respect to protecting downgradient receptors.
Targeting the mammalian target of rapamycin pathway in neurological manifestations of Covid‐19
Authors: Wang Han , Cheng Li , Yu Lanlan , Guo Zhigang 
Published: December 2023

AbstractThe diverse and severe nature of neurological manifestations associated with coronavirus disease 2019 (Covid‐19) has garnered increasing attention. Exploring the potential to decrease neurological complications in Covid‐19 patients involves targeting the mammalian target of rapamycin (mTOR) pathway as a therapeutic strategy. The mTOR pathway, widely recognised for its central role in essential cellular processes like synthesising proteins, facilitating autophagy, and modulating immune responses, has implications in various neurological disorders. Drawing parallels between these disorders and the observed neurological complications in Covid‐19, we present a comprehensive review on the current understanding of mTOR signalling in the context of severe acute respiratory syndrome coronavirus 2 infection and neuroinflammation.
Stability analysis of nonlinear systems in the presence of event‐triggered impulsive control
Authors: Yu Peilin , Deng Feiqi , Zhao Xueyan , Huang Yongjia 
Published: December 2023

AbstractThis note puts forward continuous event‐triggered impulsive control (CETIC) and dynamic event‐triggered impulsive control (DETIC) to discuss a class of (integral) input‐to‐state stability (iISS, ISS) for nonlinear systems (NSs), where the impulse sequences are produced by certain predesigned event‐triggering conditions. Different from traditionary event‐triggered control (ETC), CETIC indicates that a controller will be stimulated only if the given state‐dependent event condition is invoked. There exist no transfer of control between two continuous impulse triggered instants. Compared with the traditional static ETC, the DETIC can efficaciously lessen controller update and dramatically save energy at the same decay rate. In addition, all sample path solutions (SPS) for the system have the lowest time between events guaranteed to be positive. Utilizing CETIC strategy, we get some Lyapunov conditions to effectually avoid infinite triggering behavior and obtain the ISS‐type stability of the investigative systems. Then, one applies the theoretical consequences to NSs and derive a class of ETC mechanism with impulsive control gains (ICG) by linear matrix inequalities (LMIs). Because of the existence of timer, the DETIC strategy naturally excludes Zeno phenomena. Furthermore, conclusions in this thesis permit the upper bound estimation for the differential Lyapunov function coefficient to be time‐varying function instead of a constant in certain extant results, which means the criteria of the Lyapunov technique in this paper is less conservative and looser. Eventually, three examples with related simulations are demonstrated to indicate the rationalization and usefulness of our conclusion.
Roxadustat ameliorates vascular calcification in CKD rats by regulating HIF‐2α/HIF‐1α
Authors: Wang Yujing , Xiao Min , Cai Feng , Li Yang , Shi Tianli , Zhou Xiaoyan , Tian Shuhong , Huang Denggao 
Published: December 2023

AbstractVascular calcification (VC) is a common complication of chronic kidney disease (CKD). VC is a gene‐regulated process similar to osteogenic differentiation. There are still no convincing schemes to prevent and reduce the development of VC. It has been reported that hypoxia‐inducing factor 1α (HIF‐1α) and endothelin‐1(ET‐1) are related to VC. In this study, we found that the expression of ET‐1 and HIF‐1α was enhanced after VC, the interaction between HIF‐1α and ET‐1 was confirmed by CO‐IP and luciferase experiments. We found that ET‐1 was an upregulated differential gene of calcified vascular smooth muscle cells (VSMCs) through gene sequencing. However, hypoxia‐inducing factor 2α (HIF‐2α) and HIF‐1α have antagonistic effects on each other. HIF‐1α is a pro‐inflammatory cytokine, and HIF‐2α can improve inflammation and fibrosis. Roxadustat, as a selective PHD3 inhibitor, preferentially activates HIF‐2α. It is still unclear whether roxadustat improves VC in CKD by regulating the expression of HIF‐2α/HIF‐1α. Alizarin red staining and western blot as well as immunohistochemical results showed that roxadustat could significantly reduce the degree of vascular and VSMCs calcification in CKD rats. Serum HIF‐1α and ET‐1 were significantly decreased after roxadustat treatment. In addition, western blot results showed that roxadustat could decrease the expression of HIF‐1α and ET‐1 in vascular tissues and calcified VSMC, but HIF‐2α expression significantly increased. Interestingly, our study confirmed that activation of HIF‐1α or inhibition of HIF‐2α reversed the ameliorating effect of roxadustat on VC, proving that the effect mediated by roxadustat is HIF‐2α/HIF‐1α dependent. We have demonstrated for the first time that roxadustat improves VC in CKD rats by regulating HIF‐2α/HIF‐1α, thus providing a new idea for the application of roxadustat in VC of CKD.
Cocoa Under Heat and Drought Stress
Authors: Mensah Eric Opoku , Vaast Philippe , Asare Richard , Amoatey Christiana A. , Owusu Kwadwo , Asitoakor Bismark Kwesi , Ræbild Anders 
Published: December 2023

AbstractCocoa (Theobroma cacao L.) is an important cash crop in many tropical countries, particularly in West Africa. Heat and drought are both known to affect the physiology of cocoa plants through reduced rates of photosynthesis and transpiration, as well as changed physiological processes such as the functions of photosystems, chlorophyll synthesis, stomatal conductance and expression of heat-shock proteins. This in turn leads to decreased yields and increased risks of mortality under severe heat and drought. To help cocoa plants adapt to climate change, the literature suggests agroforestry as a potential farm management practice. It has been argued that the lack of tree cover in cocoa cultivation systems exposes the crop to heat and direct solar radiation, thus increasing evapotranspiration and the risk of drought. Drawing on data generated from two on-field studies, this chapter assesses the shade effect on cocoa’s physiological responses to drought and heat stress to determine whether shade would be beneficial under climate change scenarios. We conclude that shade improves the physiology of cocoa, but that this may not be sufficient to compensate for the negative effects of high temperatures and severe drought exacerbated by climate change in sub-optimal conditions.