bluuebunny/crossref_metadata_2025_split huggingface dataset:
Identifying and Assisting Low-Literacy Patients with Medication Use: A Survey of Community Pharmacies
Authors: Praska Jessica L , Kripalani Sunil , Seright Antoinette L , Jacobson Terry A 
Published: July 2005

BACKGROUND: Nearly one-half of adult Americans have limited functional literacy skills. Low patient literacy is associated with poor medication adherence and health outcomes. However, little is known about how pharmacies address literacy-related needs among patrons. OBJECTIVE: To determine the frequency with which pharmacies identify and provide appropriate assistance to patients with limited literacy skills and provide specific recommendations to help improve pharmacists' recognition of low health literacy, as well as strategies to improve adherence in this population. METHODS: Through a telephone-based survey of Atlanta-area pharmacies, we obtained information on (1%) whether the pharmacy attempted to identify patients with limited literacy skills, (2%) what measures were taken by the pharmacy to optimize the health care of low-literacy patients, especially with regard to medication adherence, and (3%) what services the pharmacy offered to improve adherence in general. RESULTS: The response rate among eligible pharmacies was 96.8% (N = 30%). Only 2 (7%) pharmacies reported attempting to identify literacy-related needs among their patrons. One of these facilities provided additional verbal counseling to assist low-literacy patients, and the other pharmacy involved family members, provided verbal counseling, and had patients repeat instructions to confirm comprehension. Most pharmacies reported availability of adherence aids that could help low-literacy patients if such patients were identified and targeted to receive additional assistance. These included verbal and written counseling (offered at 73% of pharmacies), packaging or organizing aids (27%), refill services (17%), and graphic or multimedia aids (13%). CONCLUSIONS: Pharmacies infrequently attempt to identify and assist patients with limited literacy skills.
Quetiapine Cross-Reactivity with Plasma Tricyclic Antidepressant Immunoassays
Authors: Caravati E Martin , Juenke JoEtta M , Crouch Barbara I , Anderson Kathleen T 
Published: July 2005

BACKGROUND: Toxicology screens obtained on patients who have overdosed on drugs frequently include tricyclic antidepressants (TCAs) as part of the evaluation. Quetiapine is an antipsychotic agent with structural similarity to the TCAs. OBJECTIVE: To determine whether quetiapine may cross-react with plasma TCA immunoassays in vitro using commonly available autoanalyzers. METHODS: Quetiapine stock solution was added to 9 separate samples of pooled drug-free human plasma to produce concentrations ranging from 1 to 640 ng/mL that were verified by gas chromatography. No quetiapine metabolites were present. Each spiked plasma sample was tested in a blinded fashion using the Abbott Tricyclic Antidepressant TDx Assay on the TDxFLx autoanalyzer in 2 separate laboratories, the Syva Emit tox Serum Tricyclic Antidepressant Assay on the AU400 autoanalyzer and the S TAD Serum Tricyclic Antidepressant Screen on the ACA-Star 300 autoanalyzer. The TDx assay is quantitative, while Emit and S TAD are qualitative screening assays with a threshold of 300 ng/mL for TCA positivity. The outcome of interest was a positive TCA result. RESULTS: The quantitative assay showed concentration-related TCA cross-reactivity beginning at quetiapine concentrations of 5 ng/mL. The 640-ng/mL spiked sample produced TCA results of 379 and 385 ng/mL in labs 1 and 2, respectively. The qualitative assays were screened as TCA positive at quetiapine concentrations of 160 and 320 ng/mL for the S TAD and Emit assays, respectively. CONCLUSIONS: Quetiapine cross-reacts with quantitative and qualitative plasma TCA immunoassays in a concentration-dependent fashion. Therapeutic use or overdose of quetiapine may result in a false-positive TCA immunoassay result.
Patient Characteristics Influencing Evaluation of Written Medicine Information: Lessons for Patient Education
Authors: Koo Michelle M , Krass Ines , Aslani Parisa 
Published: July 2005

BACKGROUND: Written medicine information (WMI) is considered an important component of patient education. Despite the wealth of information on many aspects of WMI, there is a paucity of studies examining how patient characteristics influence use and evaluation of WMI. OBJECTIVE: To investigate the influence of patient characteristics on the evaluation and intended future use of consumer medicine information (CMI), a form of WMI. METHODS: A questionnaire was administered to patients from 3 rheumatology/pain clinics in teaching hospitals and 40 community pharmacies. The questionnaire examined patients' perceptions of CMI (comprehension, perceived usefulness, design rating) and likelihood of using CMI in the future. Information on patient characteristics (demographic data, health literacy level) was also collected. Multiple regression analysis was used to examine associations between patient characteristics and their evaluation and intended future use of CMI. RESULTS: A total of 479 patients participated. Comprehension of CMI was associated with speaking primarily English at home, having attained secondary education or higher, and having adequate health literacy levels. Perceived usefulness of CMI was influenced by age and number of medications. Design rating was influenced by type of CMI, patient age, gender, and highest level of education. Intended future use was affected by health literacy level. In addition to individual patient characteristics, overall comprehension and perceived usefulness of CMI also influenced its intended future use. CONCLUSIONS: Patient characteristics were found to influence evaluation and intended future use of CMI. These findings should be taken into consideration in future research, development of WMI, and education of patients in everyday practice.
A pilot proteomic study of amyloid precursor interactors in Alzheimer's disease
Authors: Cottrell Barbara A. , Galvan Veronica , Banwait Surita , Gorostiza Olivia , Lombardo Christian R. , Williams Tristan , Schilling Birgit , Peel Alyson , Gibson Bradford , Koo Edward H. , Link Christopher D. , Bredesen Dale E. 
Published: July 2005

AbstractSeveral approaches have been used in an effort to identify proteins that interact with β‐amyloid precursor protein (APP). However, few studies have addressed the identification of proteins associated with APP in brain tissue from patients with Alzheimer's disease. We report the results of a pilot proteomic study performed on complexes immunoprecipitated with APP in brain samples of patients with Alzheimer's disease and normal control subjects. The 21 proteins identified could be grouped into five functional classes: molecular chaperones, cytoskeletal and structural proteins, proteins involved in trafficking, adaptors, and enzymes. Among the proteins identified, six had been reported previously as direct, indirect, or genetically inferred APP interactors. The other 15 proteins immunoprecipitated with APP were novel potential partners. We confirmed the APP interaction by Western blotting and coimmunolocalization in brain tissues, for 5 of the 21 interactors. In agreement with previous studies, our results are compatible with an involvement of APP in axonal transport and vesicular trafficking, and with a potential association of APP with cellular protein folding/protein degradation systems. Ann Neurol 2005;58:277–289
Crystallization behavior and viscoelasticity of bamboo‐fiber composites
Authors: Kori Yasuyuki , Kitagawa Kazuo , Hamada Hiroyuki 
Published: July 2005

AbstractThis article deals with the effect of the kneading temperature on the crystallization of a matrix polymer and the viscoelasticity of a bamboo‐fiber‐reinforced biodegradable polymer composite. Upon the investigation of poly(butylene succinate) after melt mixing, spherulite generation was observed with polarized light microscopy and differential scanning calorimetry measurements. An increase in the spherulite dimensions was observed at high kneading temperatures (>150°C) in both the neat polymer and the bamboo‐fiber composite. Spherulite growth was initiated from the bulk matrix polymer and not from the surface of the bamboo fibers. The kneading temperature influenced the melt viscoelasticity above the melting point of poly(butylene succinate) but did not influence the viscoelasticity below the melting point. © 2005 Wiley Periodicals, Inc. J Appl Polym Sci 98: 603–612, 2005
Synthesis and characterization of water‐borne crosslinked silylated polyurethane dispersions
Authors: Subramani S. , Lee J. M. , Cheong I. W. , Kim J. H. 
Published: July 2005

AbstractA series of water‐based polyurethane dispersions were synthesized by the polyaddition of isophorone diisocyanate, poly(oxytetramethylene) glycol, and dimethylol propionic acid as prepolymers, which were end‐capped and crosslinked with 3‐aminopropyl trimethoxysilane (APTMS) to produce silylated polyurethane dispersions (SPUDs). The dispersion was performed before the end‐capping reaction to avoid gelation. Pure and tetraethylene pentamine chain‐extended polyurethanes were also synthesized. The length of the soft segment and the ratio of NCO to OH were varied. The properties of these prepolymer dispersions were investigated with Fourier transform infrared, differential scanning calorimetry, thermogravimetric analysis, X‐ray diffraction, tensile and surface contact‐angle measurements, nanoindentation testing, gel content, water and xylene swellability, and storage stability. An increase in the modulus and hardness and a decrease in the tensile properties of SPUDs were noticed in comparison with a pure polyurethane dispersion. This may have been due to the smaller number of hydrogen bonds and the brittleness of the film by the formation of crosslinked siloxane networks through the hydrolysis–condensation reaction of methoxysilane groups of silylated polyurethane, and it was also confirmed by the reactions of APTMS end capping and crosslinking. The gel content of SPUDs increased with the NCO/OH ratio, and all the prepared samples were amorphous in nature. The thermal stability of SPUDs was higher than that of pure and amine‐chain‐extended polyurethane dispersions. A decrease in the water and solvent swelling and an increase in the water contact angle confirmed the effective crosslinking of the silanol groups of the silylated polyurethane. Storage‐stability results showed that all the prepared dispersions were stable for more than 3 months. © 2005 Wiley Periodicals, Inc. J Appl Polym Sci 98: 620–631, 2005
Ethical consumers in search of markets
Authors: Wheale Peter , Hinton David 
Published: August 2005

AbstractResearch in ethical consumerism has concentrated on attempts to either categorize ethical consumers or to uncover their decision‐making processes, but to‐date there have been few investigations into the key ethical drivers behind the decision‐making process. This study attempts to identify these ethical drivers within their particular product groups by means of a survey of self‐proclaimed ethical consumers distributed via a questionnaire placed in the Ethical Consumer Magazine. The findings indicate that environmental issues are ranked above human rights and animal rights/welfare issues and that the ethical consumer considers the product groups to have differential importance ranging from the food products goods group, being the most strongly associated with ethical issues, to the ‘brown goods’ group (electric goods such as stereos and TVs), which proved to be least associated with these issues. An examination of the ethical drivers within each group suggests that ethical consumers consider each product group on the basis of its bundle of ethical attributes, with differing levels of importance placed on each ethical issue within the purchase decision. Copyright © 2005 John Wiley & Sons, Ltd and ERP Environment.
Effects of Physical Property Differences on Blending
Authors: Jones P. N. , Ozcan‐Taskin G. N. 
Published: August 2005

AbstractWithin this study, the effects of viscosity differences between added and bulk liquids on mixing times were investigated. This was carried out in stirred tanks of diameterT = 0.31, 0.61, 1.83 m to study the effect of scale. Different impeller types (hydrofoils, disc turbines, and pitched blade turbines) and sizes (D = T/2 andT/3) were employed. Operating conditions for which mixing time correlations for similar property liquids could be used were identified at scales relevant to industrial applications. Recommendations are made for improving blending under operating conditions where these correlations are not applicable as the mixing times are too long.
Kinetic Study and Determination of the Enthalpies of Activation of the Dehydrogenation of Titanium‐ and Zirconium‐Doped NaAlH4 and Na3AlH6.
Authors: Kiyobayashi Tetsu , Srinivasan Sesha S. , Sun Dalin , Jensen Craig M. 
Published: July 2005

AbstractFor Abstract see ChemInform Abstract in Full Text.
Crystal Structure, Moessbauer Spectroscopy, and Magnetic Properties of a New Potassium Iron Oxyphosphate K11Fe15(PO4)18O Related to the Langbeinite‐Like Compounds.
Authors: Lajmi B. , Hidouri M. , Wattiaux A. , Fournes L. , Darriet J. , Ben Amara M. 
Published: July 2005

AbstractFor Abstract see ChemInform Abstract in Full Text.
Elemental Iodine‐Catalyzed Coupling of Alkynylsilanes with Acid Chlorides: A Facile Synthesis of α,β‐Acetylenic Ketones.
Authors: Yadav J. S. , Reddy B. V. S. , Reddy M. Sridhar 
Published: July 2005

AbstractFor Abstract see ChemInform Abstract in Full Text.
Indium‐Catalyzed Cross‐Coupling Reactions Between α,β‐Unsaturated Carbonyl Compounds and Aromatic Aldehydes.
Authors: Ohe Toshiyuki , Ohse Takuya , Mori Kenji , Ohtaka Seiji , Uemura Sakae 
Published: July 2005

AbstractFor Abstract see ChemInform Abstract in Full Text.
Azinyl Sulfides. Part 76. 1H‐ and 1‐Alkyl‐1,4‐dihydro‐4‐oxo‐3‐alkylthioquinolines from 1,4‐Dihydro‐4‐oxo‐3′‐alkylthio‐3,4′‐diquinolinyl Sulfides.
Authors: Bebenek Ewa , Chrobak Elwira , Maslankiewicz Andrzej 
Published: July 2005

AbstractFor Abstract see ChemInform Abstract in Full Text.
Nucleophilic Substitution or Dipolar 1,3‐Cycloaddition in Reactions of Cyanamide with 4‐Arylpyrimidine 1‐Oxides.
Authors: Prokhorov A. M. , Kozhevnikov D. N. , Rusinov V. L. , Chupakhin O. N. 
Published: July 2005

AbstractFor Abstract see ChemInform Abstract in Full Text.
Unusual Peptides Containing the 2,6‐Diaminopimelic Acid Framework: Stereocontrolled Synthesis, X‐Ray Analysis, and Computational Modeling. Part 2.
Authors: Galeazzi R. , Garavelli M. , Grandi A. , Monari M. , Porzi G. , Sandri S. 
Published: July 2005

AbstractFor Abstract see ChemInform Abstract in Full Text.
Hepta‐ and Octacoordinate Boron in Molecular Wheels of Eight‐ and Nine‐Atom Boron Clusters: Observation and Confirmation.
Authors: Zhai Hua‐Jin , Alexandrova Anastassia N. , Birch K. Alexander , Boldyrev Alexander I. , Wang Lai‐Sheng 
Published: July 2005

AbstractFor Abstract see ChemInform Abstract in Full Text.
Sodium Intercalation into the n = 2 Ruddlesden—Popper Type Host Y2Ti2O5S2: Synthesis, Structure, and Properties of α‐NaxY2Ti2O5S2 (0 < x ≤ 1).
Authors: Clarke Simon J. , Denis Sophie G. , Rutt Oliver J. , Hill Timothy L. , Hayward Michael A. , Hyett Geoffrey , Gal Zoltan A. 
Published: July 2005

AbstractFor Abstract see ChemInform Abstract in Full Text.
A New Class of C1‐Symmetric Monosulfoximine Ligands for Enantioselective Hetero Diels—Alder Reactions.
Authors: Bolm Carsten , Verrucci Marinella , Simic Oliver , Cozzi Pier Giorgio , Raabe Gerhard , Okamura Hiroaki 
Published: July 2005

AbstractFor Abstract see ChemInform Abstract in Full Text.
A Simple and Practical Method for the Stereoselective Synthesis of (Z)‐1‐Iodo‐1‐alkenes from 1,1‐Diiodo‐1‐alkenes.
Authors: Kadota Isao , Ueno Hirokazu , Ohno Akio , Yamamoto Yoshinori 
Published: July 2005

AbstractFor Abstract see ChemInform Abstract in Full Text.
Highly Regioselective Palladium/Copper‐Catalyzed Cross‐Coupling Reactions of Terminal Alkynes and Allenes.
Authors: Bruyere Didier , Grigg Ronald , Hinsley Joanne , Hussain Ruksana K. , Korn Stewart , Orgaz De La Cierva Cecilia , Sridharan Visuvanathar , Wang Jung 
Published: July 2005

AbstractFor Abstract see ChemInform Abstract in Full Text.
Development of Thiourea‐Based Ligands for the Palladium‐Catalyzed Bis(methoxycarbonylation) of Terminal Olefins.
Authors: Dai Mingji , Wang Cuihua , Dong Guangbin , Xiang Jing , Luo Tuoping , Liang Bo , Chen Jiahua , Yang Zhen 
Published: July 2005

AbstractFor Abstract see ChemInform Abstract in Full Text.
Hydroxylamines and Sulfinamide as Amine Components in the Petasis Boronic Acid—Mannich Reaction: Synthesis of N‐Hydroxy or Alkoxy‐α‐aminocarboxylicacids and N‐(tert‐Butyl sulfinyl)‐α‐amino Carboxylicacids.
Authors: Naskar Dinabandhu , Roy Amrita , Seibel William L. , Portlock David E. 
Published: July 2005

AbstractFor Abstract see ChemInform Abstract in Full Text.
Synthesis of 4‐(1‐Oxo‐isoindoline)‐, 4‐(5,6‐Dimethoxy‐1‐oxo‐isoindoline) and 4‐Acetamido‐Substituted Phenoxy‐3‐amino‐propane Derivatives and Their β1‐, β2‐Adrenergic Receptor Binding Studies.
Authors: Jindal Dharam Paul , Singh Babita , Sharma Neelam , Coumar Mohane S. , Bruni Giancarlo , Massarelli Paola 
Published: July 2005

AbstractFor Abstract see ChemInform Abstract in Full Text.
Thio Diels—Alder Reactions of α,β‐Unsaturated 1,3‐Oxathiolanes with Aliphatic Olefins and 1,3‐Dienes.
Authors: Kerverdo Sebastien , Lizzani‐Cuvelier Louisette , Dunach Elisabet 
Published: July 2005

AbstractFor Abstract see ChemInform Abstract in Full Text.
Synthesis and Antiproliferative Activity in vitro of New 5‐(2‐Amino‐3‐pyridyl)‐2‐thioxo‐3H‐1,3,4‐oxadiazole Derivatives.
Authors: Liszkiewicz H. , Kowalska M. W. , Wietrzyk J. , Opolski A. 
Published: July 2005

AbstractFor Abstract see ChemInform Abstract in Full Text.
2‐Thiazolidinone: A Novel Thiol Protective Surrogate of Complete Atom Efficiency, a Practical Synthesis of (+)‐Biotin.
Authors: Seki Masahiko , Kimura Mayumi , Hatsuda Masanori , Yoshida Shin‐ichi , Shimizu Toshiaki 
Published: July 2005

AbstractFor Abstract see ChemInform Abstract in Full Text.
Physicochemical and Structural Characterization of Mesoporous Aluminosilicates Synthesized from Leached Saponite with Additional Aluminum Incorporation.
Authors: Linssen Thierry , Cassiers Kristof , Cool Pegie , Lebedev Oleg , Whittaker Andrew , Vansant Etienne F. 
Published: July 2005

AbstractFor Abstract see ChemInform Abstract in Full Text.
The role of radiotherapy in cancer treatment
Authors: Delaney Geoff , Jacob Susannah , Featherstone Carolyn , Barton Michael 
Published: August 2005

AbstractRadiotherapy utilization rates for cancer vary widely internationally. It has previously been suggested that approximately 50% of all cancer patients should receive radiation. However, this estimate was not evidence‐based. The aim of this study was to estimate the ideal proportion of new cases of cancer that should receive radiotherapy at least once during the course of their illness based on the best available evidence. An optimal radiotherapy utilization tree was constructed for each cancer based upon indications for radiotherapy taken from evidence‐based treatment guidelines. The proportion of patients with clinical attributes that indicated a possible benefit from radiotherapy was obtained by adding epidemiologic data to the radiotherapy utilization tree. The optimal proportion of patients with cancer that should receive radiotherapy was then calculated using TreeAge (TreeAge Software, Williamstown, MA) software. Sensitivity analyses using univariate analysis and Monte Carlo simulations were performed. The proportion of patients with cancer in whom external beam radiotherapy is indicated according to the best available evidence was calculated to be 52%. Monte Carlo analysis indicated that the 95% confidence limits were from 51.7% to 53.1%. The tightness of the confidence interval suggests that the overall estimate is robust. Comparison with actual radiotherapy utilization data suggests a shortfall in actual radiotherapy delivery. This methodology allows comparison of optimal rates with actual rates to identify areas where improvements in the evidence‐based use of radiotherapy can be made. It provides valuable data for radiotherapy service planning. Actual rates need to be addressed to ensure better radiotherapy utilization. Cancer 2005. © 2005 American Cancer Society.
Assessment of numerical uncertainty for the calculations of turbulent flow over a backward‐facing step
Authors: Celik Ismail B. , Li Jun 
Published: August 2005

AbstractNumerical uncertainty analysis has been performed for the turbulent flow past a backward‐facing step. The analysis is based on calculations on seven non‐rectangular, but structured, grid sets that were provided by the organizers of the 2004 Lisbon Workshop (Proceedings of the Workshop on CFD Uncertainty Analysis, Lisbon, 21–22 October 2004). The calculations were performed by using a commercial code, namely, FLUENT with the Spalart–Allmaras one‐equation turbulence model. The present study constitutes a calculation verification process: a set of partial differential equations are solved on gradually refined grid sets, the selected quantities are extrapolated, and then the overall numerical uncertainty in selected quantities is estimated by various methods. Some new ideas are presented for estimating the coefficient of variation, which is related to standard deviation (or standard error of estimate in case of the least squares method).The major problem that stands out in extrapolation is the cases of non‐monotonic convergence. For such cases some alternative methods are proposed, and the results are compared to assess these methods. Copyright © 2005 John Wiley & Sons, Ltd.
Detection of genotyping errors and pseudo‐SNPs via deviations from Hardy‐Weinberg equilibrium
Authors: Leal Suzanne M. 
Published: August 2005

AbstractGenotype error can greatly reduce the power of a genetic study. For family data, genotype error can be assessed by examining marker data for non‐Mendelian inconsistencies, closely linked markers for double recombination events, and consistency of duplicate genotypes. For case‐control data, duplicate samples are genotyped, and controls are tested for deviations from Hardy‐Weinberg equilibrium (HWE). Duplicate samples can provide accurate estimates of genotyping error rates, unless systematic genotyping errors have occurred. Although genotyping errors can cause deviations from HWE, these deviations are usually small, and the power to detect them is low except for high rates of genotyping error and/or large sample sizes. An additional problem is that even when deviations from HWE are detected for marker loci, without additional experimentation it is not possible to unequivocally implicate genotyping error as the cause. The power and sample sizes necessary to detect deviations from HWE for single‐nucleotide polymorphism (SNP) data are examined for a variety of genotyping error and pseudo‐SNP models. For the majority of genotyping models examined, the power is poor to detect deviations from HWE. For example, for 1,000 controls, if an allele with a frequency of 0.1 fails to amplify for 28% of the heterozygous genotypes producing a sample error rate of 0.05, the power is 0.51 to detect a deviation from HWE at an alpha level of 0.05. On the other hand, the detection of deviations from HWE for pseudo‐SNPs (paralogous and ectopic sequence variants) for the majority of models examined produces a power of >0.8 for sample sizes as small as 50 individuals. Genet. Epidemiol. © 2005 Wiley‐Liss, Inc.