bluuebunny/crossref_metadata_2025_split huggingface dataset:
Oxidative stress as the bridge between dyslipidemia and peritoneal ultrafiltration failure: A bi-center cross-sectional cohort study
Authors: Stepanova N. , Korol L. , Burdeyna O. , Snisar L. , Rysyev A. , Filonov V. , Poperechny I. 
Published: December 2023

stress and dyslipidemia are common concerns in patients undergoing peritoneal dialysis (PD) and are associated with adverse clinical outcomes. However, the interplay between these factors and their impact on peritoneal ultrafiltration (UF) remains poorly understood.
Methods: In this bi-center cross-sectional cohort study, we examined the relationships between dyslipidemia, oxidative stress, and peritoneal UF in patients undergoing PD. A comprehensive set of oxidative stress markers, lipid profiles, and clinical variables were assessed.
Results. Among the 114 patients, aged 55 (48-65) years, with a dialysis vintage of 31 (14-50) months, 76 (66.7%) were diagnosed with dyslipidemia. Patients with dyslipidemia experienced significantly higher proportions of patients with peritoneal UF below 400 mL per day, suggesting ultrafiltration failure (UFF) (χ2 = 4.9, p = 0.02). An elevated D/P creatinine ratio was associated with higher levels of total cholesterol (r = 0.39, p = 0.0005), low-density lipoprotein cholesterol (r = 0.26, p = 0.02), triglycerides (r = 0.33, p = 0.005), and the atherogenic index of plasma (AIP) (r = 0.27, p = 0.01). UF rate displayed a positive correlation with high-density lipoprotein cholesterol (r = 0.31, p = 0.003) and a negative correlation with AIP (r = -0.33, p = 0.004). The ROC analysis revealed that an AIP value exceeding 4.3 could effectively predict UFF, with a sensitivity of 83.3% and a specificity of 73.4%
Dyslipidemia was significantly associated with increased intensity of oxidative stress, with elevated malondialdehyde (MDA) (p = 0.0002), oxidative stress index (OSI) (p < 0.0001), and reduced antioxidant markers. UFF was also associated with higher oxidative stress, as indicated by increased MDA (p = 0.005) and OSI (p = 0.0009). Patients with both dyslipidemia and UFF exhibited the highest levels of oxidative stress (p < 0.0001). Taking potential confounders into account in the ANCOVA analysis, a significant interaction effect of dyslipidemia (F = 7.6, p = 0.007) and UF rate (F = 8.6, p = 0.004) on oxidative stress was observed.
Conclusion. Dyslipidemia and UFF are independently associated with elevated oxidative stress in PD patients, and their coexistence exacerbates this oxidative burden. Understanding these relationships is crucial for developing interventions to improve clinical outcomes in this population. Targeted therapies addressing oxidative stress and dyslipidemia warrant further investigation.
VALUE ORIENTATIONS AS A BASIC CONSTRUCT FOR THE FORMATION OF PROFESSIONAL WORLDVIEW OF THE FUTURE MUSIC TEACHER
Authors: Tkach Mariia 
Published: December 2023

The article reveals that the current stage of social development requires a radical renewal of the content of higher art education, in which axiological priorities should become decisive in the professional training of future music teachers. It has been found that this problem is especially exacerbated by the integration aspirations of our country to join the Common European Educational Area, in which the individual is formed as a subject of culture, his or her spiritual and value sphere develops, etc. This requires a transition from a knowledge-centered to a culture-centered model of higher education, where a person is formed as a subject of culture, develops its spiritual and valuable sphere, etc.Therefore, the problem of spiritual and value formation of a personality through music is actualized in the content of post-nonclassical higher art education, creating prerequisites for the formation of such a phenomenon as a holistic professional worldview in future music teachers. The analysis of the structural components (cognitive-educative, emotional-valuable, activity-practical and professional-reflective) of this phenomenon has shown that the basic construct of professional worldview is the system of value orientations of the individual.In order to study the dynamics in the formation of value orientations of students of music specialties, the second stage of a special experimental study was conducted at the Anatolii Avdiievskyi Faculty of Arts of Dragomanov Ukrainian State University. In the course of the empirical study, using the methods of observation, questionnaires, interviews, testing, diachronic analysis, ranking, etc., it was confirmed that studentsʼ orientations towards professional values were the most stable, reflecting the main focus of their motives, interests and needs for future professional activities.
Keywords: values; value orientations; professional worldview; axiological priorities; theoretical construct; music teacher; post-nonclassical; higher art education.
Sosialisasi sanitasi lingkungan upaya pencegahan stunting pada ibu rumah tangga di wilayah Kerja Puskesmas Sukajadi Kelurahan Sukajadi Kabupaten Banyuasin Tahun 2023
Authors: Minarti  , Faridahtul Aulia Nasution Fitri , Amalia Rizki , Ciselia Dewi 
Published: December 2023

Kegiatan sosialisasi tentang sanitasi lingkungan dalam upaya pencegahan Stunting pada ibu rumah tangga yang bertujuan untuk memberikan pemahaman baik prilaku sikap dan keyakinan secara mendalam kepada ibu rumah tangga di wilayah kerja puskesmas sukajadi kabupaten banyuasin sehingga ibu rumah tangga mampu melakukan antisipasi kejadian Stunting dan dapat peningkatan terkait sanitasi lingkungan. Kegiatan pengabdian dilakukan di Desa Pangkalan Benteng Kecamatan Talang Kelapa Kabupaten Banyuasin oleh 30 peserta. Kegiatan ini melibatkan pelaksanaan studi pendahuluan dan sosialisasi. Keberhasilan kegiatan pengabdian masyarakat terlihat dari peningkatan pengetahuan peserta mengenai bagaimana cara menjaga sanitasi lingkungan agar terjhindar dari factor resiko akan kejadian stuntting. ibu rumah tangga yang hadir dalam pengabdian masyarakat termotivasi untuk merubah prilaku dan sikap dalam menjaga sanitasi lingkungan. Hasil dari pengabdian Masyarakat diharapatkan dapat membantu pertumbuhan dan berkembang bayi khususnya balita 5 tahun (BALITA) secara optimal dan maksimal, dengan demikian anak dimasa depan akan mampu belajar baik secara fisik, emosional, sosial serta mampu berinovasi dan berkompetisi di tingkat nasional maupun global.
Effect of Laser on Phagocytic Activity of Polymorphoneutrophils
Authors: Khaleel Aida Z. , Al-Ghurabi Batool H. , Al-Saady Luma G. 
Published: December 2023

Background: It is well known that the low level laser irradiation has act on immune system cells in a number of ways, one of them includes increasing phagocytic activity of irradiated cells. This study was established to shed light on the possible effect of laser irradiation on phagocytic activity of polymorphoneutrophils.Subjects and methods: Fresh blood samples were obtained from twenty healthy volunteers for phagocytosis assay. The polymorphoneutrophils were isolated from blood and examined their phagocytic capacity befor and after exposure to laser irradiation.Results: The present study revealed a significant increase in the mean percentage of phagocytosis after exposure to diode laser of wave length (632) nm (red), which was further increased by increasing the time of exposure.Conclusion: The current study suggests that low level of laser can increase the phagocytic activity of polymorphoneutrophils, and this increase propotional to increaseing the time of exposure.
The effects of aspirin and fenugreek seed on the testes of white mice
Authors: Chaloob Amal K. , Qasim Hadeel M. , Gassim Musheer H. 
Published: December 2023

Background: Fenugreek seeds are used as food ingredient in traditional medicines; also aspirin is an incredible chemical with many useful benefits in the medical field. The objective was to study the effect of aspirin and fenugreek on testes of mice.Method: 20 white male mice weighing (18-23gm) were divided into four groups 5 each. Group 1, represented control, group 2, mice treated with fenugreek seed (100mg/KgB.W), group 3 mice treated with aspirin (10mg/Kg B.W), group 4 mice treated with aspirin and fenugreek seed for 21 days. Body weight and testes weights were recorded. Histopathological examination of testes was carried out.Results: a significant decrease (P<0.05) in body weight of mice treated with aspirin when compared to the other groups. A significant decrease (P<0.001) in testicular weight of mice treated with aspirin as compared to control and other groups was noted. Structural changes in testes have shown that: aspirin administration caused a decrease in seminiferous tubules diameter associated with increase in connective tissue between them and basement membrane thickness of seminiferous tubules. While fenugreek seed reverse these changes.Conclusion: fenugreek seeds exhibited antioxidant property that could ameliorate the alternations induced in mice treated with aspirin. Further studies are needed to be done on mammals to support our findings.
Fracture Simulation of Concrete Beams to assess softening behavior by varying different fractions of Aggregates
Authors: Vishwanatha H. S. , Muralidhara S. , Raghu Prasad B. K. 
Published: December 2023

Simulating the concrete fracture unlike other elastic and brittle materials quite different due to its quasibrittleness. The present research focussed on assess softening behavior by varying different fractions of aggregates and cement matrix in micro details. Extended Finite Element Method (XFEM) for crack modeling implemented for simulating and visualizing crack propagation through Cement matrix, Interfacial Transition Zone (ITZ) and Aggregates . This approach permits the initializing crack by from enrichment zone and propagation of crack through element by traction separation law .The crack formation initiates when the maximum principal tensile stress reaches the tensile strength. The work involves creating python script for iterative process of random distribution of aggregates with in the matrix using Monte Carlo method and creating Cohesive zone element for zero thickness ITZ. introduces a finite element modeling technique for investigating multiscale fracture characteristics. This approach encompasses multiple levels of analysis, including the generation of aggregate particles using a Monte Carlo method implemented via a Python script. Additionally, we replicate the Interfacial Transition Zone (ITZ) between aggregate and mortar in the model. The load-deflection curves can be used to assess the softening behavior of concrete and suggest the realistic fraction of coarse aggregate in mix proportion to impart more ductility to beams.
Investigations on tool wear behavior in turning AISI 304 stainless steel: An empirical and neural network modeling approach
Authors: Chinchanikar Satish , Gadge Mahendra 
Published: December 2023

Machining with a cutting edge with extensive damage or a fractured cutting edge significantly influences the machining performance. Therefore, investigations on tool wear behavior, their forms, and wear mechanisms will be very helpful in the current environment of sustainable manufacturing. On the other hand, the machining economy is negatively impacted by replacing the tool well before its useful life. This proactive maintenance planning reduces the risk of sudden tool failure and potential workpiece damage. Accordingly, the current work creates empirical and ANN models to predict flank wear growth for turning AISI 304 stainless steel using a MTCVD-TiCN/Al2O3 coated carbide tool. The experiments were designed to cover a broad range of operating conditions to ensure the model's accuracy and applicability in practical machining scenarios. An ANN was modeled using a feedforward backpropagation machine learning technique. In this study, a higher prediction accuracy of 0.9975 was achieved with ANN model as compared to the empirical model. The most common wear mechanism observed is metal adhesion, followed by fracture due to the pulling away of adhered material. The developed models have been found to be valuable for optimizing cutting parameters and enhancing tool life in machining.
РЕАКЦІЯ МІЖНАРОДНОЇ СПІЛЬНОТИ НА ЗБРОЙНЕ ВТОРГНЕННЯ РОСІЙСЬКОЇ ФЕДЕРАЦІЇ В УКРАЇНУ (лютий – квітень 2022 року)
Authors: КОВАЛЬ Михайло , СЕГЕДА Сергій , ШЕВЧУК Василь 
Published: December 2023

Широкомасштабне збройне вторгнення російської федерації (далі — рф) в Україну викликало жорстку реакцію міжнародного співтовариства, яке засудило цю пряму агресію проти суверенної держави України, а рф визнана країною-агресором, що відкрито порушила міжнародні та між- державні угоди, розв’язавши на європейському континенті загарбницьку війну. У статті висвітлюється реакція міжнародних інституцій, демо- кратичних країн світу на збройне вторгнення рф в Україну. Ними було застосовано різні механізми тиску на росію, щоб примусити її військово- політичне керівництво вивести війська та військову техніку з української території, що не дало бажаного результату. Світова спільнота усвідо- мила реальність російської воєнної загрози і для інших європейських країн.
Героїчний опір Сил оборони України, їх успіхи у захисті Києва, від- битті ворога на стратегічних напрямках у лютому – на початку квітня 2022 року сприяли зміні ставлення до України: лідери країн Заходу пе- рейшли від висловлення занепокоєння діями рф до військової, гуманітар- ної, фінансової допомоги українцям. Тоді ж сформувалася дипломатична та військова коаліція держав світу з метою забезпечення злагодженої підтримки українців у їх боротьбі проти російських окупантів. Військо- во-політичні завдання України — перемогти у російсько-українській війні та відновити територіальну цілісність України у її міжнародно визна- них кордонах — співпали з інтересами цивілізованих країн світу.
Pengaruh Kualitas Produk dan Citra Merek Terhadap Kepuasan Konsumen
Authors: Reiza Mochammad , Sudarwanto Tri , Irawati Winaika 
Published: December 2023

Penelitianibertujuan untuk menganalisis Pengaruh Kualitas Produk dan Citra Merek Terhadap Kepuasan Konsumen Assfak Assyuhada Jombang. Penelitian kuantitatif menjadi metode dalam penelitian ini. Populasi penelitian 100 pengguna Assfak Assyuhada di Jombang. Sampel ditentukan melalui sampling purposive dengan menggunakan sampel 80 responden. Hasil penelitian menunjukkan bahwa : (1) Persepsi kualitas produk berpengaruh positif dan signifikan terhadap kepuasan konsumen (2) Citra merek berpengaruh positif dan signifikan terhadap kepuasan konsumen (3) kualitas produk dan citra merek simultan berpengaruh positif dan signifikan terhadap kepuasan konsumen.
Pandrug-resistant Acinetobacter baumannii from different clones and regions in Mexico have a similar plasmid carrying the blaOXA-72 gene
Authors: Fernández-Vázquez José Luis , Hernández-González Ismael Luis , Castillo-Ramírez Santiago , Jarillo-Quijada Ma Dolores , Gayosso-Vázquez Catalina , Mateo-Estrada Valeria Eréndira , Morfín-Otero Rayo , Rodríguez-Noriega Eduardo , Santos-Preciado José Ignacio , Alcántar-Curiel María Dolores 
Published: December 2023

BackgroundMultidrug-resistant Acinetobacter baumannii is a common hospital-acquired pathogen. The increase in antibiotic resistance is commonly due to the acquisition of mobile genetic elements carrying antibiotic resistance genes. To comprehend this, we analyzed the resistome and virulome of Mexican A. baumannii multidrug-resistant isolates.MethodsSix clinical strains of A. baumannii from three Mexican hospitals were sequenced using the Illumina platform, the genomes were assembled with SPAdes and annotated with Prokka. Plasmid SPAdes and MobRecon were used to identify the potential plasmid sequences. Sequence Type (ST) assignation under the MLST Oxford scheme was performed using the PubMLST database. Homologous gene search for known virulent factors was performed using the virulence factor database VFDB and an in silico prediction of the resistome was conducted via the ResFinder databases.ResultsThe six strains studied belong to different STs and clonal complexes (CC): two strains were ST208 and one was ST369; these two STs belong to the same lineage CC92, which is part of the international clone (IC) 2. Another two strains were ST758 and one was ST1054, both STs belonging to the same lineage CC636, which is within IC5. The resistome analysis of the six strains identified between 7 to 14 antibiotic resistance genes to different families of drugs, including beta-lactams, aminoglycosides, fluoroquinolones and carbapenems. We detected between 1 to 4 plasmids per strain with sizes from 1,800 bp to 111,044 bp. Two strains from hospitals in Mexico City and Guadalajara had a plasmid each of 10,012 bp pAba78r and pAba79f, respectively, which contained the blaOXA-72 gene. The structure of this plasmid showed the same 13 genes in both strains, but 4 of them were inverted in one of the strains. Finally, the six strains contain 49 identical virulence genes related to immune response evasion, quorum-sensing, and secretion systems, among others.ConclusionResistance to carbapenems due to pAba78r and pAba79f plasmids in Aba pandrug-resistant strains from different geographic areas of Mexico and different clones was detected. Our results provide further evidence that plasmids are highly relevant for the horizontal transfer of antibiotic resistance genes between different clones of A. baumannii.
Echocardiographic parameters indicating left atrial reverse remodeling after catheter ablation for atrial fibrillation
Authors: Angelini Eleonora , Sieweke Jan-Thorben , Berliner Dominik , Biber Saskia , Hohmann Stephan , Oldhafer Maximiliane , Schallhorn Sven , Duncker David , Veltmann Christian , Bauersachs Johann , Bavendiek Udo 
Published: December 2023

BackgroundThe echocardiographic parameters total atrial conduction time (PA-TDI duration), left atrial (LA) volume index (LAVI), and LA strain reflect adverse atrial remodeling and predict atrial fibrillation (AF).ObjectivesThe aim of this study was to investigate echocardiographic parameters indicating reverse LA remodeling and potential associations with AF recurrence after pulmonary vein isolation (PVI).MethodsThis prospective observational study consecutively enrolled patients scheduled for PVI for symptomatic AF. Electrocardiogram (ECG) test and transthoracic echocardiography were performed the day before and after PVI and again 3 months later. AF recurrence was determined by Holter ECG at 3 months, and telephone follow-up at 12 months, after PVI. The parameters of LA remodeling [PA-TDI, LAVI, and LA strain analysis: reservoir strain (LASr), conduit strain (LAScd), contraction strain (LASct)] were determined by transthoracic echocardiography.ResultsA total of 48 patients were included in the study (mean age: 61.4 ± 12.2 years). PA-TDI significantly decreased the day after PVI compared with the baseline (septal PA-TDI 103 ± 13 vs. 82 ± 14.9 ms, p ≤ 0.001; lateral PA-TDI 122.4 ± 14.8 vs. 106.9 ± 14.4 ms, p ≤ 0.001) and at the 3-month follow-up (septal PA-TDI: 77.8 ± 14.5, p ≤ 0.001; lateral PA-TDI 105.2 ± 16.1, p ≤ 0.001). LAVI showed a significant reduction at the 3-month follow-up compared with the baseline (47.7 ± 14.4 vs. 40.5 ± 9.7, p &lt; 0.05). LASr, LAScd, and LASct did not change after PVI compared with the baseline. AF recurred in 10 patients after PVI (21%). Septal PA-TDI, septal a', and LAVI/a' determined the day after PVI were associated with AF recurrence.ConclusionChanges in echocardiographic parameters of LA remodeling and function indicate that functional electromechanical recovery preceded morphological reverse remodeling of the left atrium after PVI. Furthermore, these changes in echocardiographic parameters indicating LA reverse remodeling after PVI may identify patients at high risk of AF recurrence.
Transcriptional changes during isoproterenol-induced cardiac fibrosis in mice
Authors: Nanda Disha , Pant Priyanka , Machha Pratheusa , Sowpati Divya Tej , Kumarswamy Regalla 
Published: December 2023

Introduction: β-adrenergic stimulation using β-agonists such as isoproterenol has been routinely used to induce cardiac fibrosis in experimental animal models. Although transcriptome changes in surgical models of cardiac fibrosis such as transverse aortic constriction (TAC) and coronary artery ligation (CAL) are well-studied, transcriptional changes during isoproterenol-induced cardiac fibrosis are not well-explored.Methods: Cardiac fibrosis was induced in male C57BL6 mice by administration of isoproterenol for 4, 8, or 11 days at 50 mg/kg/day dose. Temporal changes in gene expression were studied by RNA sequencing.Results and discussion: We observed a significant alteration in the transcriptome profile across the different experimental groups compared to the saline group. Isoproterenol treatment caused upregulation of genes associated with ECM organization, cell–cell contact, three-dimensional structure, and cell growth, while genes associated with fatty acid oxidation, sarcoplasmic reticulum calcium ion transport, and cardiac muscle contraction are downregulated. A number of known long non-coding RNAs (lncRNAs) and putative novel lncRNAs exhibited differential regulation. In conclusion, our study shows that isoproterenol administration leads to the dysregulation of genes relevant to ECM deposition and cardiac contraction, and serves as an excellent alternate model to the surgical models of heart failure.
The effect on blink frequency of a selective blue-filtering photochromic lens in patients with benign essential blepharospasm
Authors: Monschein Tobias , Zrzavy Tobias , Weber Corinna , Kuzmina Zoya , Gutstein Walter , Sycha Thomas 
Published: December 2023

ObjectiveThe aim of this clinical study was to assess the impact of a non-invasive selective blue-filtering photochromic lens coating Crizal Prevencia on the treatment and response of benign essential blepharospasm (BEB).Patients and methodsTwenty-four patients were recruited in the outpatient clinic of the Medical University of Vienna in a randomized, double-blind, cross-over study design. Blink frequencies were assessed in patients with BEB before and 14 days after intervention with either a filtering ophthalmic lens or a placebo lens, respectively. Outcome parameters include sub-group analysis of a blink frequency under six different conditions: three photopic conditions, one resting condition, one reading condition, and one video game condition.ResultsFrom 24 recruited patients, 15 patients were available for final analysis. Comparing the optical blue filtering lens to placebo, showed a reduced blink frequency in specific subtests, but not compared to baseline.DiscussionIn conclusion, optical filtering glasses might have a beneficial effect on BEB and provide a non-invasive therapeutic add-on option, in addition to botulinum neurotoxin therapy, for patients with BEB and should necessarily be further investigated in a multicenter setting, resulting in larger sample sizes to gain valid information about the effect of photochromic blue filter glasses in BEB.Clinical trial registration: https://drks.de/search/en/trial/DRKS00032135, DRKS00032135.