bluuebunny/crossref_metadata_2025_split huggingface dataset:
Analisa Pengaruh Ukuran Mesh dan Curring Time Pada Komposit Serbuk Kayu Nyatoh Terhadap Pengujian Tarik
Authors: Somawardi Somawardi , Akbar Rafsanjani Alfarobbi , Yuliyanto Yuliyanto , Sukanto Sukanto 
Published: January 2024

Beragam jenis pohon tumbuh di Indonesia, salah satunya adalah pohon Nyatoh. Kegunaan, pohon kayu nyatoh ini sangat bermanfaat sebagai bahan kontruksi rumah, pembuatan mebel, dan lain sebagainya. Pada proses pengolahan pohon nyatoh menjadi bahan jadi akan menghasilkan serutan atau serbuk, tetapi pemanfaatan serutan atau serbuk belum dimanfaatkan secara maksimal. Sehingga dari sisa proses tersebut membuat lingkungan sekitar menjadi kotor dan tidak enak untuk dipandang. Material komposit ini memiliki keunggulan yaitu kekuatan yang bisa diatur, kekuatan lelah yang sangat baik, ketahanan terhadap korosi, dan ringan serta biaya produksi yang sangat rendah. Tujuan penelitian ini adalah mengetahui nilai uji tarik komposit serbuk kayu nyatoh pada fraksi volume 5%, 10%, 15% dengan faktor ukuran mesh 100, 150, 200 dan curring time pada waktu 2 jam dengan pemanasan suhu 60 , 80 , 100. Metode penelitian yang digunakan adalah metode full factorial. Pembuatan material komposit tersebut menggunakan metode hand-lay-up. Nilai kekuatan Tarik tertinggi pada penelitian ini yaitu pada sampel 5% dengan ukuran mesh 200 dan temperatur curring time pada suhu 60 dengan hasil uji tarik yaitu 30,60 Mpa. Sedangkan hasil kekuatan tarik terendah sebesar 10,97 Mpa pada fraksi serbuk 5% dengan ukuran mesh 100 dan curring time dengan temperature suhu 60 ?. Ukuran mesh sangat berpengaruh terhadap pengujian Tarik dimana semakin tinggi mesh yang dipakai maka kekuatan tarik semakin meningkat. Sedangkan proses pemanasan (curring time) juga memberikan pengaruh, tetapi tidak begitu besar, semakin tinggi temperatur curring time akan menyebabkan penurunan kekuatan Tarik.
Inverse association between type 2 diabetes and hepatocellular carcinoma in East Asian populations
Authors: Huo Jinlong , Xu Yaxuan , Chen Xingqi , Yu Jie , Zhao Lijin 
Published: January 2024

AimsTo investigate the potential association between type 2 diabetes (T2D) and hepatocellular carcinoma (HCC) in East Asian populations using Mendelian randomization (MR) analyses.MethodsBidirectional Mendelian randomization (MR) studies were conducted using summary statistics from genome-wide association studies (GWAS) related to T2D and HCC. The potential effects of confounders such as chronic hepatitis B, chronic hepatitis C, body mass index, and alcohol intake frequency were corrected using a multivariate MR study. Various MR methods, including the inverse variance weighted (IVW) approach, were used to estimate the associations between T2D and HCC. Sensitivity analysis and assessment of heterogeneity were performed to ensure the robustness of the results.ResultsIn the forward MR study, the IVW approach of MR analysis suggested an inverse association between T2D and HCC, with a risk odds ratio of 0.8628 (95% confidence interval [CI], 0.7888–0.9438). Furthermore, even after adjusting for BMI, chronic hepatitis B, and alcohol intake frequency, this study still supports the inverse association between T2D and HCC. Additional MR methods provided further support for this relationship. Sensitivity analysis and assessment of heterogeneity confirmed the robustness of the results. The reverse MR analysis did not show a clear impact of genetic liability to HCC on reduced risk of T2D(OR=0.9788; 95% CI, 0.9061-1.0574).ConclusionThis study provides evidence of an inverse association between T2D and HCC in East Asian populations using MR analysis. Further studies are warranted to validate these findings.
Systemic effects of hypophosphatasia characterization of two novel variants in the ALPL gene
Authors: Martínez-Heredia Luis , Muñoz-Torres Manuel , Sanabria-de la Torre Raquel , Jiménez-Ortas Ángela , Andújar-Vera Francisco , González-Cejudo Trinidad , Contreras-Bolívar Victoria , González-Salvatierra Sheila , Gómez-Vida José María , García-Fontana Cristina , García-Fontana Beatriz 
Published: January 2024

IntroductionHypophosphatasia (HPP) is an inborn metabolic error caused by mutations in the ALPL gene encoding tissue non-specific alkaline phosphatase (TNSALP) and leading to decreased alkaline phosphatase (ALP) activity. Although the main characteristic of this disease is bone involvement, it presents a great genetic and clinical variability, which makes it a systemic disease.MethodsPatients were recruited based on biochemical assessments. Diagnosis was made by measuring serum ALP and pyridoxal 5-phosphate levels and finally by Sanger sequencing of the ALPL gene from peripheral blood mononuclear cells. Characterization of the new variants was performed by transfection of the variants into HEK293T cells, where ALP activity and cellular localization were measured by flow cytometry. The dominant negative effect was analyzed by co-transfection of each variant with the wild-type gene, measuring ALP activity and analyzing cellular localization by flow cytometry.ResultsTwo previously undescribed variants were found in the ALPL gene: leucine 6 to serine missense mutation (c.17T&gt;C, L6S) affecting the signal peptide and threonine 167 deletion (c.498_500delCAC, T167del) affecting the vicinity of the active site. These mutations lead mainly to non-pathognomonic symptoms of HPP. Structural prediction and modeling tools indicated the affected residues as critical residues with important roles in protein structure and function. In vitro results demonstrated low TNSALP activity and a dominant negative effect in both mutations. The results of the characterization of these variants suggest that the pleiotropic role of TNSALP could be involved in the systemic effects observed in these patients highlighting digestive and autoimmune disorders associated with TNSALP dysfunction.ConclusionsThe two new mutations have been classified as pathogenic. At the clinical level, this study suggests that both mutations not only lead to pathognomonic symptoms of the disease, but may also play a role at the systemic level.
Practical tips by peer support in chronic vestibular hypofunction: an exploratory survey
Authors: Vermorken Bernd Lode , Schouten Anna C. , van Laer Lien , van Toor Alonda , Devocht Elke M. J. , van de Berg Raymond 
Published: January 2024

IntroductionPatients with chronic vestibular hypofunction typically suffer from dizziness, imbalance and oscillopsia (blurred vision); symptoms that pose challenges to everyday life. Currently, advice on how to deal with such challenges is mainly provided by health care professionals (i.e., ENT-surgeons, neurologists, physiotherapists and psychologists). However, fellow patients with a similar condition and a true appreciation of the lived experiences, are likely to provide valuable support and advice as well. The purpose of this study, therefore, was to collect tips and advice from patients with chronic vestibular hypofunction.MethodsAn exploratory survey was designed to collect tips from fellow chronic vestibular hypofunction patients on how to cope with disease-related challenges in everyday life. The survey was distributed both online and in person. The list of tips was coded and analyzed thematically and deductively, by using the international classification of functioning, disability, and health (ICF) model.ResultsIn total, 425 tips were obtained from the 179 participants. Most tips were coded under “environmental factors” (46%) and “activities and participation” (39%). The remaining tips were categorized as “body functions” (15%). No tips were about “body structures.” The participants coped with their daily struggles by investing in assistive products and technology, like adapted bikes, special footwear, walking frames. They described the importance of ensuring minimal light intensity for visibility (i.e., installing light sources in dark places). During activities, participants gave the advice to avoid bumpy roads and obstacles, and highlighted the necessity of adequate visual fixation to maintain balance. To ensure optimal activity, participants emphasized the importance of managing energy and taking sufficient rest.DiscussionThis study gives insight into how patients with chronic vestibular hypofunction cope with everyday struggles due to their symptoms. These tips can expand advice given by healthcare professionals. Knowing that fellow patients experience similar struggles and learned to deal with their struggles in adequate ways, might offer support and help patients focus on possibilities rather than on disabilities. Further research should investigate the effect of sharing tips to see whether improvement in (mental) health can be achieved in patients with chronic vestibular hypofunction.
Relationship between vaginal microecology and human papillomavirus infection as well as cervical intraepithelial neoplasia in 2,147 women from Wenzhou, the southeast of China
Authors: Zang Lejing , Feng Renqian , Huang Yitong , Huang Jiahe , Hu Yan 
Published: January 2024

ObjectiveThe female reproductive tract is a significant microecological region, and its micro-environment can directly affect women’s cervical health. This research aimed to investigate the effect of vaginal microecology on human papillomavirus (HPV) infection and cervical intraepithelial neoplasia(CIN).MethodsA retrospective cohort study enrolling 2,147 women who underwent a colposcopic examination between August 2021 and August 2022 was conducted. The relationship between vaginal microecology and HPV infection as well as cervical lesions were assessed using the chi-square test, univariate and multivariate logistic regression analyses, and Cochran-Armitage trend test.ResultsHPV infection was linked to the imbalance of vaginal microecology [odds ratio (OR)=3.00, 95% confidence interval (CI)=1.66–5.43; P&lt;0.001]. Clue cell (OR=1.59, 95% CI=0.99–2.54; P=0.054) and sialidase (OR=1.54, 95% CI=1.01–2.35; P&lt;0.046) were considered as significant risk factors for HPV infection. Further analysis showed that vaginal microecological disorder was more likely to be detected in patients infected with HPV 16/18 subtypes (OR=9.86, 95% CI=2.37–41.80; P=0.002). Although there was no significant correlation between the incidence of vaginal microecological disorder and the severity of cervical lesions (P &gt; 0.05), the proportions of abnormal PH value (OR=2.6, 95% CI=1.63–10.42; P=0.001) and abnormal vaginal cleanliness (OR=2.6, 95% CI=1.36–4.0; P= 0.004) increased as the histological stage progressed.ConclusionVaginal microecology associates with HPV infection and the progression of cervical lesions. Detection of vaginal secretion may contribute to the development of targets for micro-environmental modulation with probiotics and the reduction of the incidence of cervical cancer.
Case report: EBV-positive epithelioid follicular dendritic cell sarcoma with CD30 expression: a highly challenging diagnosis
Authors: Chen Ying , He Xin , Zhu Xingyan , Xu Yujuan , Guo Deyu 
Published: January 2024

IntroductionFollicular dendritic cell sarcoma (FDCS) is a rare tumor entity with a wide range of anatomical sites and strong heterogeneity in morphology and immunohistochemistry, making it highly susceptible to misdiagnosis. There are two types of FDCS: conventional FDCS and EBV+ inflammatory FDCS. It is currently suggested that the former has nothing to do with EBV infection. Moreover, they have distinctively different clinicopathological characteristics.Case descriptionA 69-year-old male patient was admitted to our hospital after 4 months of progressive enlargement of the neck mass. Positron emission tomography/computed tomography (PET/CT) examination showed multiple enlarged lymph nodes in the body. After cervical lymph node excision and biopsy, it was found that the tumor cells were epithelioid and diffusely expressed EBER and CD30. It was initially diagnosed as poorly differentiated cancer and lymphoma. In subsequent differential diagnosis, we found that it strongly stained CD21 and CD23, which was approved the diagnosis of EBV+ FDCS.ConclusionEpithelioid FDCS is very rare. EBV-positive FDCS with abnormal expression of CD30 has not been reported. Whether EBV also plays an important role in conventional FDCS requires more cases to be verified. Our case provides valuable research clues for further understanding the pathological characteristics of this tumor entity.
Age- and sex-specific normative values for muscle mass parameters in 18,625 Brazilian adults
Authors: Coelho-Júnior Hélio José , Marques Fillipi Lopes , Sousa Caio Victor , Marzetti Emanuele , Aguiar Samuel da Silva 
Published: January 2024

BackgroundThe present study aimed to provide age- and sex-specific normative values for muscle mass parameters in Brazilian adults.MethodsData pertaining to Brazilian adults (18+ years) who attended a nutritional clinical between January 2018 and July 2022 were analyzed. Muscle mass parameters were assessed using a bioimpedance digital scale (InBody 230, GBC BioMed NZ). Assessments were conducted under standard conditions, with participants refraining from physical exercise for 96 h and from eating or drinking (including water) for 8 h before evaluations.ResultsA total of 18,625 Brazilian adults were analyzed. Normative values for absolute and relative (height, m2) muscle mass and appendicular muscle mass (ASM) were calculated. In addition, specific age-related changes in muscle mass parameters were observed. In women, muscle mass peaked between the ages of 40–49 before gradually declining at an average rate of 5.7% per decade from the sixth decade of life onwards. ASM reached its peak earlier, during the third decade of life, and started to decline later, from 50 to 59 years. In contrast, absolute and ASM peaked at 40–49 years and declined from the sixth decade of life in men. Both sexes displayed a slightly greater decline in ASM than in muscle mass (13 vs. 12%).ConclusionsThe present study provides normative values for absolute and relative muscle mass and ASM in Brazilian adults. Furthermore, important specific age-related changes in muscle mass parameters were observed. These data have public health implications and might serve as a reference tool to guide health professionals.
Analisis Self Regulated Learning Strategies Pada Siswa Kelas XI SMA Negeri 11 Semarang
Authors: Shafrinia Naifa , Fitriana Siti 
Published: December 2023

Self Regulated Learning Strategies merupakan bagian dari Self Regulated Learning yang biasa diartikan dengan sebutan strategi regulasi diri dalam belajar. Self Regulated Learning (regulasi diri dalam belajar) digambarkan juga sebagai strategi-strategi yang digunakan siswa untuk mengatur kognisinya serta penggunaan strategi mengelola sumber pengetahuan untuk memperoleh hasil belajarnya. Penelitian ini fokus untuk mengetahui bagaimana tingkat Self Regulated Learning Strategies pada siswa kelas XI SMA Negeri 11 Semarang. Menggunakan metode kuantitatif, jenis/pendekatan penelitian survey. Teknik analisis data berupa teknik analisis deskriptif. Populasi penelitian siswa kelas XI SMA Negeri 11 Semarang, menggunakan Purposive Sampling dengan teknik pengambilan jumlah sampel dari populasi menggunakan rumus slovin didapatkan 82 sampel, alat ukur yang digunakan yaitu dengan Self Regulated Learning Strategies adaptasi dari instrumen Motivated Strategies for Learning Questionnare (MLSQ berbentuk skala likert. Hasil yang diperoleh melalui penelitian ini menunjukkan bahwa self regulated learning strategies pada siswa kelas XI SMA Negeri 11 Semarang berada pada kategori tinggi.Self Regulated Learning Strategies
Analysis of heart rate and scores in student archery athletes
Authors: Oktafiranda Nadya Dwi , Ihsani Sri Indah , Kuswahyudi Kuswahyudi 
Published: December 2023

This research aims to determine the heart rate when aiming at DKI Jakarta student archery athletes which will be carried out in May 2023. The research method used is the cross-sectional survey design method. This research instrument is a polar type H10 as a heart rate monitor used by the samples during the archery process. This research was conducted in the Pulomas field, East Jakarta. Sample selection used purposive sampling technique. The sample in this study were DKI Jakarta student athletes who met the criteria, namely 10 recurve athletes. The stages carried out in the data collection process were, heart rate during aiming was measured when the athlete was in the aiming position until release during the archery process using three arrows with a time of 180 seconds per series and carried out in 5 series with a total of 15 arrows. The results of the study showed that male archers had a lower heart rate with an average of 128.13 bpm, while female athletes had an average of 142.37 bpm. The scores for male athletes were higher with an average of 7.97 compared to female athletes with an average score of 6.47. Based on the results of the independent sample test, it is known that the sig. on the heart rate variable 0.026<0.05. Meanwhile, the sig value. on the score variable 0.042<0.05. Each has a sig value. < 0.05. Thus, it can be concluded that there are significant differences in the results of measuring heart rate and scores between male and female athletes.Key words: Heart rate, archery athletes, university students
Studi Interaksi Obat Antihipertensi Pasien Rawat Inap
Authors: Nisa Adinda 
Published: December 2023

Hipertensi merupakan suatu keadaan peningkatan tekanan darah sistolik lebih dari 140 mmHg dantekanan darah diastolik lebih dari 90 mmHg pada dua kali pengukuran dengan selang waktu 5 menit dalamkeadaan tenang. Hipertensi sering diikuti dengan penyakit lain. Sehingga pengobatan hipertensi seringdikombinasikan bersama obat lain dan berpotensi meningkatkan terjadinya interaksi obat. Penelitian inibertujuan untuk mengidentifikasi tingkat keparahan interaksi obat antihipertensi pada pasien rawat jalanRSUD Abdoer Rahem Situbondo periode Juli sampai Desember 2022. Penelitian ini termasuk penelitianobservasi (survei), jenis penelitian survei analitik dan data diambil secara retrospektif. Jenis analisis dataadalah analisis univariat dan data dikelola secara teoritik menggunakan Stockley Drug Interaction dan reviewaplikasi drugs.com. Dari 135 rekam medis yang memenuhi kriteria inklusi, diperoleh 81 % berpotensimengalami interaksi obat dan 19 % tidak mengalami interaksi obat. Antihipertensi yang sering diresepkan danpaling besar menimbulkan interaksi obat adalah candesartan (37,8 %). Dari 135 rekam medis, ditemukan 422kasus tingkat keparahan interaksi obat, dengan tingkat keparahan minor sebesar 21,5 %, tingkat keparahanmoderat sebesar 64,4% dan tingkat keparahan mayor sebesar 13,9 %.

ABSTRACTHypertension is a condition of increasing systolic blood pressure of more than 140 mmHg anddiastolic blood pressure of more than 90 mmHg on two measurements with an interval of 5 minutes in a calmstate. Hypertension is often followed by other diseases. So that the treatment of hypertension is oftencombined with other drugs and has the potential to increase the occurrence of drug interactions. This studyaims to identify the severity of antihypertensive drug interactions in outpatients at RSUD Abdoer RahemSitubondo from July to December 2022. This study was an observational study (survey), an analytic surveystudy type, and data were collected retrospectively. The type of data analysis was univariate analysis and thedata was managed theoretically using Stockley Drug Interaction and a drug.com application review. Of the135 medical records that met the inclusion criteria, it was found that 81% had the potential to experiencedrug interactions and 19% did not experience drug interactions. The antihypertensive that is often prescribedand causes the greatest drug interactions is candesartan (37.8%). From 135 medical records, 422 cases ofdrug interaction severity were found, with a minor severity of 21.5%, a moderate severity of 64.4% and amajor severity of 13.9%.
Peningkatan Produktivitas pada Proses Building Tyre Menggunakan Work Sampling Method (Studi Kasus: PT. PN Balikpapan)
Authors: Siagian Tri Apriana , Leksono Vridayani Anggi 
Published: December 2023

PN Balikpapan merupakan salah satu support office yang bergerak dalam bidang overhaul alat berat sebagai pendukung kegiatan pertambangan disemua operating sites. Penelitian ini dilakukan disalah satu departemen yaitu departemen Tyre Production (TRP) dimana TRP memiliki tugas melakukan repair dan retread tyre untuk support all site PT. PN. Diketahui pada periode Januari s/d Juli 2022 target produksi tyre tidak tercapai, jumlah aktual tyre yang diproduksi perusahaan tidak sama dengan plan yang telah ditetapkan perusahaan. TRP memiliki banyak pesanan perbaikan ban, kemudian mengakibatkan semakin tingginya target produksi yang harus dicapai oleh operator. Untuk meningkatkan produktivitas tersebut maka perlu dilakukannya pengukuran produktivitas kerja usaha-usaha untuk menetapkan waktu baku yang dibutuhkan guna menyelesaikan suatu pekerjaan. Salah satu metode pengukuran terdiri dari membuat sejumlah besar pengamatan tentang aktivitas kerja mesin, proses, atau karyawan dengan menggunakan metode work sampling. Penelitian ini bertujuan untuk mengetahui waktu normal dan waktu standar, persentase kegiatan produktif, non produktif dan idle serta memberikan rekomendasi perbaikan untuk meningkatkan produktivitas perusahaan. Dari hasil penelitian didapatkan waktu normal sebesar 5,3 jam sedangkan waktu standar 7,2 jam dan didapatkan 4 rekomendasi peningkatan produktivitas berdasarkan top five kegiatan idle.

Kata Kunci: Work sampling, Waktu standar, Waktu normal, Productivity improvement
Does Today’s School/Education Respond to Society’s Needs and Expectations of Reality and the Future?
Authors: Dworak Alina , Rzymełka-Frąckiewicz Agata , Wilk Teresa 
Published: December 2023

Objectives of the research: The aim of our study was to show that education, although rooted in the past and drawing heavily from the present, especially in modern times, is focused on the upcoming future, on preparing for life in a future marked by rapid changes in the development of civilisation and the hopes, threats and challenges associated with it.
Research methods: A critical analysis of scientific/research texts was carried out.
A short description of the context of the issue: The everyday reality of our lives increasingly proves that there is a great need for the harmonious and comprehensive development of the personality of children and young people. Living in a world of constant re-evaluation and clearly articulated tendencies close to ethical relativism, in a world of ecological threats, chaos in the field of beauty criteria and rapidly increasing diseases of civilisation at the end of the twentieth century (no less so two decades later), people must have a clear and distinct perspective on what they should be aiming at, on which values they should base their lives and how they should live as free, rational and responsible beings (Śnieżyński, 1999, p. 27).
Research findings: The modern school becomes a place of creating needs related to the future as well as a place for locating the intentional expectations of young people and their parents in relation to functioning in reality and in the future. School has become an institution that is required to prepare young people well for life/social functioning in an unknown future.
Conclusions and/or recommendations: At this point, one should ask whether the institution of a modern school is able to equip a young person with everything necessary to experience success, generally speaking, so that they will not be excluded or marginalised in the global world (Rzymełka-Frąckiewicz, 2020, pp. 93–108; Rzymełka-Frąckiewicz & Wilk, 2014, pp. 83–94).