bluuebunny/crossref_metadata_2025_split huggingface dataset:
Resolution of megaesophagus after correction of a paraesophageal hernia
Authors: Rolph Kerry E , Ryan John , Yool Donald , Liuti Tiziana 
Published: October 2023

Case summary A 6-year-old female Siamese cat presented with an 8-week history of vomiting and progressive hyporexia. On presentation, the cat was found to have a hypochloremic alkalosis. Imaging demonstrated hiatal hernia and megaesophagus. Exploratory laparotomy demonstrated a paraesophageal hiatal hernia. The hernia was reduced, phrenoplasty and esophagopexy were performed, and a gastrotomy tube was placed. Treatment of the hernia led to resolution of the megaesophagus. Relevance and novel information Megaesophagus can occur secondarily to paraesophageal hernia in the cat. In this case, correction of the paraesophageal hernia led to complete resolution of the esophageal dilation and all associated clinical signs.
Are positive clinical gains observed following physiotherapy treatment for persistent pelvic pain sustained to 12 months following programme completion? A follow up study
Authors: Beaumont Tara 
Published: October 2023

Introduction: Persistent pelvic pain is a common and often debilitating health condition, which is associated with significant healthcare costs. A three-treatment arm clinical trial investigating the impact of physiotherapy in the management of persistent pelvic pain demonstrated positive clinical outcomes, as measured at the conclusion of the programmes, in terms of pain score and pain impact. This study aimed to test the sustainability of the clinical gains observed through to 12 months post-programme completion. Methods: Participants who completed the clinical trial ( N = 66) were contacted as they neared the 12 months anniversary of the completion of their treatment programme. Returned data was collated and analysed against data obtained during the trial, allowing comparison pre-treatment, post-treatment and at 12 months following programme completion. Results: There were 24 returned outcome measurement documents, representing a 38% response rate. Of the three treatments arms piloted in the trial, one arm demonstrated further clinical improvement across a range of domains in the 12 months following treatment, while participants in the other two treatment arms returned data suggesting mild clinical decline. However, when comparing pre-treatment baseline data with data obtained at 12 months post treatment, all three treatment cohorts returned positive clinical gains across all measures. This effect was more pronounced in those who maintained three to six monthly contact with the department following treatment programme completion. Discussion: Physiotherapy treatment – either individual sessions, or a series of individual sessions coupled with group education ± group exercise – results in positive clinical gains from baseline assessment that are sustained through to 12 months following treatment programme completion. Universal trial number: U1111-1228-4810 ANZCTR.
Comparison of the Efficacy of 17% EDTA and 17% EDTA-S as Root Conditioning Agents: An in vitro Study
Authors: Anurag T. , Pasupuleti Mohan Kumar , Penmetsa Gautami S. , Gottumukkala Sruthima N.V.S. , Ramesh K.S.V. , Bypalli Vivek 
Published: October 2023

Aim: The study’s objective is to assess the capacity of 17% EDTA (ethylene diamine tetraacetic acid) and 17% EDTA-S (sodium lauryl sulphate) on periodontally infected root surfaces as well as their capacity to remove the smear layer. Materials and Methods: Groups A (EDTA) and B (EDTA-S) were randomly selected from among 40 single-rooted teeth that had to be extracted due to the mobility. Sections of these teeth were subjected to a 3-minute “Active Burnishing Technique” treatment with 17% EDTA and 17% EDTA-S, followed by a 2-minute saline washing, and then investigated by using an electron microscope. The teeth’s root surface changes were evaluated using Sampaio’s Index, surface morphology, smear layer presence, dentinal tubule patency, and other factors. The results of this study were statistically examined using the paired “t” test. The significance threshold was established at P-value = .05. Results: The outcomes demonstrated that Group B benefited statistically from the elimination of the smear layer and the patency of the dentinal tubules ( P < .01). In the EDTA and EDTA-S groups, there were 85.508.75 and 91.706.20 patent dentinal tubules revealed, respectively. The total surface area exposed by EDTA was 163.88 ± 24.68 and EDTA-S was 182.91 ± 28.16 with a P-value <.01. Conclusion: According to the study’s findings, as compared to EDTA, EDTA-S is more successful at exposing dentinal tubules and removing the smear layer, making it a useful root conditioning agent.
EasyCGTree: a pipeline for prokaryotic phylogenomic analysis based on core gene sets
Authors: Zhang Dao-Feng , He Wei , Shao Zongze , Ahmed Iftikhar , Zhang Yuqin , Li Wen-Jun , Zhao Zhe 
Published: October 2023

Abstract
Background
Genome-scale phylogenetic analysis based on core gene sets is routinely used in microbiological research. However, the techniques are still not approachable for individuals with little bioinformatics experience. Here, we present EasyCGTree, a user-friendly and cross-platform pipeline to reconstruct genome-scale maximum-likehood (ML) phylogenetic tree using supermatrix (SM) and supertree (ST) approaches.

Results
EasyCGTree was implemented in Perl programming languages and was built using a collection of published reputable programs. All the programs were precompiled as standalone executable files and contained in the EasyCGTree package. It can run after installing Perl language environment. Several profile hidden Markov models (HMMs) of core gene sets were prepared in advance to construct a profile HMM database (PHD) that was enclosed in the package and available for homolog searching. Customized gene sets can also be used to build profile HMM and added to the PHD via EasyCGTree. Taking 43 genomes of the genus Paracoccus as the testing data set, consensus (a variant of the typical SM), SM, and ST trees were inferred via EasyCGTree successfully, and the SM trees were compared with those inferred via the pipelines UBCG and bcgTree, using the metrics of cophenetic correlation coefficients (CCC) and Robinson–Foulds distance (topological distance). The results suggested that EasyCGTree can infer SM trees with nearly identical topology (distance < 0.1) and accuracy (CCC > 0.99) to those of trees inferred with the two pipelines.

Conclusions
EasyCGTree is an all-in-one automatic pipeline from input data to phylogenomic tree with guaranteed accuracy, and is much easier to install and use than the reference pipelines. In addition, ST is implemented in EasyCGTree conveniently and can be used to explore prokaryotic evolutionary signals from a different perspective. The EasyCGTree version 4 is freely available for Linux and Windows users at Github (https://github.com/zdf1987/EasyCGTree4).
Analysis of applying a patient safety taxonomy to patient and clinician-reported incident reports during the COVID-19 pandemic: a mixed methods study
Authors: Purchase Thomas , Cooper Alison , Price Delyth , Dorgeat Emma , Williams Huw , Bowie Paul , Fournier Jean-Pascal , Hibbert Peter , Edwards Adrian , Phillips Rhiannon , Joseph-Williams Natalie , Carson-Stevens Andrew 
Published: October 2023

Abstract
Background
The COVID-19 pandemic resulted in major disruption to healthcare delivery worldwide causing medical services to adapt their standard practices. Learning how these adaptations result in unintended patient harm is essential to mitigate against future incidents. Incident reporting and learning system data can be used to identify areas to improve patient safety. A classification system is required to make sense of such data to identify learning and priorities for further in-depth investigation. The Patient Safety (PISA) classification system was created for this purpose, but it is not known if classification systems are sufficient to capture novel safety concepts arising from crises like the pandemic. We aimed to review the application of the PISA classification system during the COVID-19 pandemic to appraise whether modifications were required to maintain its meaningful use for the pandemic context.

Methods
We conducted a mixed-methods study integrating two phases in an exploratory, sequential design. This included a comparative secondary analysis of patient safety incident reports from two studies conducted during the first wave of the pandemic, where we coded patient-reported incidents from the UK and clinician-reported incidents from France. The findings were presented to a focus group of experts in classification systems and patient safety, and a thematic analysis was conducted on the resultant transcript.

Results
We identified five key themes derived from the data analysis and expert group discussion. These included capitalising on the unique perspective of safety concerns from different groups, that existing frameworks do identify priority areas to investigate further, the objectives of a study shape the data interpretation, the pandemic spotlighted long-standing patient concerns, and the time period in which data are collected offers valuable context to aid explanation. The group consensus was that no COVID-19-specific codes were warranted, and the PISA classification system was fit for purpose.

Conclusions
We have scrutinised the meaningful use of the PISA classification system’s application during a period of systemic healthcare constraint, the COVID-19 pandemic. Despite these constraints, we found the framework can be successfully applied to incident reports to enable deductive analysis, identify areas for further enquiry and thus support organisational learning. No new or amended codes were warranted. Organisations and investigators can use our findings when reviewing their own classification systems.
A meta-analysis of treatment for early-stage cervical cancer: open versus minimally invasive radical trachelectomy
Authors: Lv Zi , Wang Yu-ying , Wang Yu-wen , He Jun-jie , Lan Wen-wei , Peng Jia-ying , Lin Zi-han , Zhu Ruo-fei , Zhou Jie , Chen Zi-qi , Jiang Ying-hui , Yuan Yi , Xiong Jian 
Published: October 2023

Abstract
Background
In previous systematic reviews, meta-analysis was lacking, resulting in the statistical difference between the data of different surgeries being impossible to judge. This meta-analysis aims to contrast the fertility results and cancer outcomes between open and minimally invasive surgery.

Method
We systematically searched databases including PubMed, Embase, Cochrane, and Scopus to collect studies that included open and minimally invasive radical trachelectomy. A random-effect model calculated the weighted average difference of each primary outcome via Review Manager V.5.4.

Result
Eight studies (1369 patients) were incorporated into our study. For fertility results, the Open group excels MIS group in pregnancies-Third trimester delivery [OR = 2.68; 95% CI (1.29, 5.59); P = 0.008]. Nevertheless, there is no statistical difference in clinical pregnancy, miscarriage, and second-trimester rate. Concerning cancer outcomes, no difference was detected in the overall survival [OR = 1.56; 95% CI (0.70, 3.45); P = 0.27] and recurrence [OR = 0.63; 95% CI (0.35, 1.12); P = 0.12]. Concerning surgery-related outcomes, the comprehensive effects revealed that the estimated blood loss of the Open group was higher than that of the MIS group[MD = 139.40; 95% CI (79.05, 199.75); P < 0.0001]. However, there was no difference between the postoperative complication rate in the two groups [OR = 1.52; 95% CI (0.89, 2.60); P = 0.12].

Conclusion
This meta-analysis suggested that the fertility result of the Open group may be better than the MIS group, while the MIS group has better surgery-related outcomes. Owing to the poor cases of our study, a more robust conclusion requires more relevant articles in the future.

Systematic review registration
PROSPERO CRD42022352999.
Assessment of sensorimotor and strength related function of breast cancer patients during systemic drug therapy: a prospective observational study
Authors: Tuğral Alper , Arıbaş Zeynep , Akyol Murat , Bakar Yeşim 
Published: October 2023

Abstract
Background
Chemotherapy is a well-known risk factor for sensorial and motor disturbances. Chemotherapy induced peripheral neuropathy (CIPN) which predominantly affects sensory nerves might cause a diminished fine motor function. This prospective observational study aimed to assess the sensorimotor functions of breast cancer patients before, during, and after chemotherapy.

Methods
A total of 56 breast cancer patients were evaluated at three different times as follows: T1 (before chemotherapy), T2 (middle chemotherapy), and T3 (completion of chemotherapy). Motor function was assessed with handgrip strength (HGS), peripheral muscle strength (PMS), and the Minnesota Manual Dexterity Test (MMDT). Semmes Weinstein Monofilament Test (SWMT) was performed to assess the sensory function. Fatigue was evaluated with the European Organization for Research and Treatment of Cancer Quality of Life Module Cancer Related Fatigue (EORTC-QLQ-FA12), respectively.

Results
HGS and MMDT were found significant (χ2: 11.279, p = 0.004 and χ2: 9.893, p = 0.007, respectively) whereas PMS was not found significant (F (2,110) = 1.914, p = 0.152). Pairwise comparisons with Bonferroni adjustments revealed that HGS was found significant between T1 and T3, while significant results were obtained between T1 and T2 as well as T2 and T3 in MMDT (p = 0.01 and p = 0.042). There were significant results in some reference points of SWMT, though they were not found after pairwise comparisons with Bonferroni adjustment (p > 0.05). Fatigue was found significantly increased from T1 through T3 (Median: 19.44 vs 27.77, z: -2.347, p = 0.019, Wilcoxon test).

Conclusion
Our study showed that decreased handgrip strength and fine motor function, as well as increased fatigue, are evident during the chemotherapy. SWMT can be an optional assessment in the context of tracking changes in cutaneous sensation during chemotherapy due to its non-invasive, cheap, and easily repeatable features among cancer patients. To preserve functional capacity as well as independence in daily living, precautions and follow up assessments during the systemic therapy process should be integrated as early as possible to prevent future deteriorations in daily life for patients who undergo chemotherapy.

Trial registration
NCT04799080.
Pelvic floor dysfunction: prevalence and associated factors
Authors: Peinado-Molina Rocío Adriana , Hernández-Martínez Antonio , Martínez-Vázquez Sergio , Rodríguez-Almagro Julián , Martínez-Galiano Juan Miguel 
Published: October 2023

Abstract
Background
Pelvic floor dysfunction in women encompasses a wide range of clinical disorders: urinary incontinence, pelvic organ prolapse, fecal incontinence, and pelvic-perineal region pain syndrome. A literature review did not identify any articles addressing the prevalence of all pelvic floor dysfunctions.

Objective
Determine the prevalence of the group of pelvic floor disorders and the factors associated with the development of these disorders in women.

Material and methods
This observational study was conducted with women during 2021 and 2022 in Spain. Sociodemographic and employment data, previous medical history and health status, lifestyle and habits, obstetric history, and health problems were collected through a self-developed questionnaire. The Pelvic Floor Distress Inventory (PFDI-20) was used to assess the presence and impact of pelvic floor disorders. Pearson's Chi-Square, Odds Ratio (OR) and adjusted Odds Ratio (aOR) with their respective 95% confidence intervals (CI) were calculated.

Results
One thousand four hundred forty-six women participated. Urinary incontinence occurred in 55.8% (807) of the women, fecal incontinence in 10.4% (150), symptomatic uterine prolapse in 14.0% (203), and 18.7% (271) reported pain in the pelvic area. The following were identified as factors that increase the probability of urinary incontinence: menopausal status. For fecal incontinence: having had instrumental births. Factors for pelvic organ prolapse: number of vaginal births, one, two or more. Factors for pelvic pain: the existence of fetal macrosomia.

Conclusions
The prevalence of pelvic floor dysfunction in women is high. Various sociodemographic factors such as age, having a gastrointestinal disease, having had vaginal births, and instrumental vaginal births are associated with a greater probability of having pelvic floor dysfunction. Health personnel must take these factors into account to prevent the appearance of these dysfunctions.
Effects of rehabilitation therapy based on exercise prescription on motor function and complications after hip fracture surgery in elderly patients
Authors: Che Yan-Jun , Qian Zongna , Chen Qi , Chang Rui , Xie Xiaofeng , Hao Yue Feng 
Published: October 2023

Abstract
Background
Exercise rehabilitation training is an important measure for improving the prognosis of patients with hip fractures. However, the particular program that works effectively and the efficiency of exercise therapy are still controversial.

Objective
To compare the effects of usual postoperative care combined with rehabilitation based on exercise prescription on motor function and complications in elderly patients who underwent surgery for hip fracture.

Methods
This was an observational study. A total of 71 elderly patients with hip fractures who were treated with hip arthroplasty and internal fixation of the proximal femur with an intramedullary nail at Suzhou Municipal Hospital from October 2020 to December 2021 were included; 11 cases were excluded (eight cases were excluded due to loss of follow-up, two due to deaths from other causes, and one due to other reasons). Finally, 60 patients (18 males and 42 females) were included. Patients were randomly assigned to the control (n = 30) and experimental (n = 30) groups using a random number generator. Patients in the control group received usual postoperative care, whereas those in the experimental group received usual postoperative care combined with rehabilitation training based on the principles of exercise prescription. We recorded the motor function (Harris hip score), daily living ability (Barthel Index), and complications at discharge and 1, 3, and 6 months postoperatively for statistical analysis.

Results
The Harris hip score and Barthel Index score were significantly higher at 1, 3, and 6 months postoperatively than at discharge in both groups (p < 0.05). The Harris hip score and Barthel Index score at discharge and 1, 3, and 6 months postoperatively were significantly higher in the experimental group than in the control group (p < 0.05). The incidence of complications at 6 months postoperatively was significantly lower in the experimental group than in the control group (13% vs. 37%).

Conclusions
Rehabilitation therapy based on exercise prescription helps improve hip function and the ability to perform activities of daily living and related postoperative complications after hip fracture surgery in elderly patients. The findings of our study will guide decision-making in clinical practice and improve the clinical management of hip fractures in elderly patients postoperatively.
Spinal anesthesia for L5-S1 interlaminar endoscopic lumbar discectomy: a retrospective study
Authors: Liu Guanyi , Zhao Jinsong , Yuan Liyong , Shi Fangling , Zhang Liangguang 
Published: October 2023

Abstract
Objective
This study aimed to report our experience with spinal anesthesia (SA) in patients undergoing L5-S1 interlaminar endoscopic lumbar discectomy (IELD) and clarify its advantages and disadvantages.

Methods
One hundred twelve patients who underwent IELD for an L5-S1 disc herniation under SA were retrospectively analyzed. SA with 0.5% ropivacaine was administered using a 27-gauge fine needle. Intraoperatively, the volume and level of SA, surgical time, blood loss, and cardiopulmonary complications were documented. Postoperative data was collected included the number of patients who ambulated on the day of surgery, incidence of complications and were then statistically analyzed.

Results
Analgesia was complete throughout the entire operation in all patients and no other adjuvant intraoperative analgesic drugs were needed. Mean visual analog scale scores for intraoperative and early postoperative (24 h) pain were 0 and 2.43 ± 1.66. SA was administered at the L3-4 interspace in 34 patients (30.4%) and the L2-3 interspace in 78 (69.6%). Administration was successful with the first attempt in all patients. Mean operation time was 70.12 ± 6.52 min. Mean intraoperative blood loss volume was 20.71 ± 5.26 ml. Ninety-eight patients ambulated on the same day as surgery. Mean length of hospital stay was 24.36 ± 3.64 h. Dural injury without damaging the nerve root occurred in one patient. One patient experienced recurrent disc herniation. Intraoperative hypotension and respiratory distress occurred in five (4.5%) and three (2.7%) patients, respectively. Three patients (2.7%) received postoperative analgesia therapy and two (1.8%) experienced nausea. Two patients (1.8%) developed urinary retention. Spinal headache, cauda equina syndrome, and neurotoxicity did not occur.

Conclusion
SA can achieve satisfactory pain control for patients undergoing IELD with a low incidence of adverse events. SA may be a useful alternative to local and general anesthesia for IELD surgery. Future randomized controlled trials are warranted to investigate.
Drug resistance and influencing factors of biofilm bacteria in upper urinary calculi patients with double J stent indwelling
Authors: Chen Qian , Ye JunBing , Li Xiao Bin , Zeng Ke , Zeng Shiping 
Published: October 2023

Abstract
Objective
To analyze the distribution and drug resistance of biofilm bacteria infected with upper urinary calculi patients with double J stent indwelling, and to explore the influencing factors of Biofilm Bacteria Infections.

Methods
A total of 400 patients with upper urinary calculi who adopted double J stent inserting in our hospital from January 2019 to January 2022 were included. Urine and double J stent samples were collected, pathogen cultures were performed, and then drug sensitivity test analysis was carried out for isolates. Univariate and multivariate logistic regression analyzes were used to analyze the influencing factors of patients with double J stent associated biofilm bacteria infections.

Results
A total of 13 strains (3.2%) of biofilm bacteria were detected in urine samples and 168 strains (42%) in double J stent samples (P < 0.05), 95 strains (23.7%) of pathogenic bacteria were separated from urine samples and 117 strains (29.2%) from double J-stent samples (P > 0.05). Escherichia coli were the most common bacteria. There was significantly higher drug resistance observed in biofilm bacteria versus urine-cultured pathogens (P < 0.05). Advanced age, long-term catheterization, inadequate water intake, hypoproteinemia, abnormal renal function, and diabetes mellitus were independent risk factors for biofilm bacteria infection associated with double J stent(P < 0.05).

Conclusion
Among the upper urinary calculi patients with double J stent indwelling, the positive rate and drug resistance of biofilm bacteria obtained from double J stent were significantly higher than that from urine. More attention should be paid to the factors that influence biofilm bacteria infections.