bluuebunny/crossref_metadata_2025_split huggingface dataset:
A caring academia? Afterword to the Foreword by Gráinne de Búrca, Rosalind Dixon, and Marcela Prieto Rudolphy
Authors: Osella Stefano 
Published: January 2025

Abstract
This Afterword to the Foreword by Gráinne de Búrca, Rosalind Dixon, and Marcela Prieto Rudolphy aims to foster the debate on the recognition of care as a means to achieve gender equality in academia. Drawing inspiration from the ongoing revaluation of care across various disciplines, including constitutional law, the article emphasizes the importance of a cultural revaluation of care within academic institutions. It interrogates whether such a shift could favor a more equitable distribution of care-related tasks and foster a symbolic move toward values such as collegiality, reciprocal nurturing and support, and relationality. Finally, the Afterword asks whether such a transformation could be a crucial first step toward a more sustainable higher-education and research environment.
Anomaly detection algorithms for vehicle-to-network interaction operator-level interactive control support systems based on machine learning
Authors: Wang Wen , Li Peijun , Yang Ye , Qin Jian , Zu Guoqiang , Xu Ke , Zhang Xiaoqing , Yu Jiancheng 
Published: January 2025

Abstract
This study proposes a charging transaction model based on a consortium blockchain to establish a mutual trust network between operators and power supply companies. The model employs the Practical Byzantine Fault Tolerance algorithm for transaction validation and utilizes smart contracts to handle account transfers, evaluations, and queries. Through case analysis, it is confirmed that the proposed integration of the particle swarm optimization-K-means method can simultaneously achieve low false-positive rates and high detection rates. Experimental results demonstrate that the anomaly detection algorithm in this paper effectively screens out abnormal data from on-chain charging data.
Electric Trends of Laboratory Medicine: Five Years of Growth, Visibility, and Opportunity
Authors: Strain Colleen , Ravalico Tricia 
Published: January 2025

Abstract

Background
Laboratory medicine has and continues to undergo significant transformation. This paper reviews top trends associated with laboratory medicine using insights, evidence, and outcomes derived from the UNIVANTS of Healthcare ExcellenceTM award program.

Methods
Seventy-two judge-approved best practices of measurably better healthcare were assessed for trends and insights related to outcomes and opportunities for highlighting the value of laboratory medicine.

Results
Ten industry-relevant and insightful takeaways are identified that span stakeholders and key performance indicators.

Conclusion
With evidence that spans 5 years, the findings not only substantiate the critical value of laboratory medicine, but reveal trends associated with award-winning teams, proven integrated clinical care initiatives, and the measurement of their associated outcomes.
Intramural hematomas and astrocytic infiltration precede perivascular inflammation in a rat model of repetitive low-level blast injury
Authors: Gama Sosa Miguel A , De Gasperi Rita , Lind Rachel H , Pryor Dylan , Vargas Danielle C , Perez Garcia Georgina S , Perez Gissel M , Abutarboush Rania , Kawoos Usmah , Sowa Allison , Zhu Carolyn W , Janssen William G M , Hof Patrick R , Ahlers Stephen T , Elder Gregory A 
Published: January 2025

Abstract
In modern war theaters, exposures to blast overpressures are one of the most common causes of brain injury. These pervasive events result in acute and chronic cerebrovascular degenerative processes. Using a rat model of blast-induced mild traumatic brain injury, we identified intramural periarterial hematomas as early primary acute lesions induced by blast exposures. These lesions resulted in intravascular cell death, cell layer reorganization, and plasma leakage into the intraperiarterial basal membranes that constitute the intraperiarterial drainage system (IPAD). Plasma metalloproteases, including MMP-9, in the IPAD basal membranes may degrade extracellular matrix components compromising normal cerebral interstitial fluid drainage, arterial structure and function leading to chronic vascular degenerative processes. Related subacute effects of blast exposure included increased MMP-9 expression in perivascular reactive astrocytes and the extension of astrocytic processes through the layers of affected vessels. These results, in combination with normal levels of proinflammatory cytokines and the absence of proinflammatory MHC II-expressing microglia, suggest an astrocytic role in the clearing of intravascular hematomas and provide further mechanistic evidence that blast-induced vascular degenerative processes may precede the onset of neurovascular inflammation.
Long-day induced flowering requires DNA hypermethylation in orchardgrass
Authors: Yang Zhongfu , Yan Haidong , Nie Gang , Xiao Jiajing , Wang Jianping , Feng Guangyan , Li Dandan , Huang Linkai , Zhang Xinquan 
Published: January 2025

Abstract
Flowering, a pivotal plant lifecycle event, is intricately regulated by environmental and endogenous signals via genetic and epigenetic mechanisms. Photoperiod is a crucial environmental cue that induces flowering by activating integrators through genetic and epigenetic pathways. However, the specific role of DNA methylation, a conserved epigenetic marker, in photoperiodic flowering remains unclear. This study integrated methylome, transcriptome, and gene expression analyses in orchardgrass (Dactylis glomerata) to elucidate the molecular mechanisms underlying long-day (LD) flowering. We found that LD treatment led to CHH hypermethylation, which was associated with the increased expression of RNA-dependent DNA methylation pathway components. LD-induced CHH hypermethylation in promoters correlated with upregulated photoperiod pathway genes and down-regulated miRNAs. The suppression of DNA methylation under LD conditions delays flowering, highlighting the critical role of hypermethylation. Additionally, the novel-miR1736-3p was identified as a negative regulator of DgFT. These findings elucidate the promotion of flowering through LD-induced CHH hypermethylation and provide insights into using epigenetic techniques to control plant flowering time.
Tissue-specific responses of the central carbon metabolism in tomato fruit to low oxygen stress
Authors: Li Xindan , Terzoudis Konstantinos , Hertog Maarten L A T M , Nicolaï Bart M 
Published: January 2025

Abstract
Tomato (Solanum lycopersicum L.) is an important model plant whose fleshy fruit consists of well-differentiated tissues. Recently it was shown that these tissues develop hypoxia during fruit development and ripening. Therefore, we employed a combination of metabolomics and isotopic labeling to investigate the central carbon metabolic response of tomato fruit tissues (columella, septa and mesocarp) to low O2 stress. The concentration and 13C-label enrichment of intermediates from the central carbon metabolism were analyzed using gas chromatography–mass spectrometry. The results showed an increase in glycolytic activity and the initiation of fermentation in response to low O2 conditions. In addition, the up-regulation of the GABA shunt and accumulation of amino acids, alanine and glycine, were observed under low O2 conditions. Notably, tissue specificity was observed at the metabolite level, with concentrations of most metabolites being highest in columella tissue. In addition, there were tissue-specific differences in the central carbon metabolism with the columella exhibiting the highest metabolic activity and sensitivity to the changes in O2 concentration, followed by septa and mesocarp tissues. Our results are consistent with common plant responses and adaptive mechanisms to low O2 stress, while unravelling some tissue-specific differences, increasing our understanding of the intact fruit response to low O2 stress.
Conserved and novel roles of the bHLH transcription factor SPATULA in tomato
Authors: Martínez-Estrada Eduardo , Bernal-Gallardo Judith Jazmín , López-Gómez Pablo , de la Mora-Franco Daniela , Celso-Espinoza Marisela , Guerrero-Esperanza Moisés , Díaz-Ramírez David , Marsch-Martínez Nayelli , Ordaz-Ortiz José Juan , de Folter Stefan 
Published: January 2025

Abstract
Arabidopsis has served as a model plant for studying the genetic networks that guide gynoecium development, but less is known about other species. Tomato (Solanum lycopersicum) is a model for fleshy fruit development and ripening. Here we used tomato to study the transcription factor SPATULA (SPT), a bHLH-family member that in Arabidopsis is known to be important for gynoecium development. We analysed the expression of the SlSPT gene during flower and fruit development and the interaction of the SlSPT protein with proteins previously reported as interactors of AtSPT in the gynoecium. We also generated and characterized loss-of-function tomato lines using CRISPR–Cas9. The results showed that SlSPT forms homodimers and partially conserves the interactions reported in Arabidopsis with some HECATE proteins. We conclude that SlSPT has a role in floral organ development, particularly in stamen fusion, style and stigma development, and trichome formation on the carpels. Furthermore, lack of SlSPT caused altered exocarp pigmentation. A metabolomic analysis of the exocarp showed perturbations in several pathways in the slspt mutant, with flavonoid biosynthesis being the most affected, which could potentially impact the nutritional value of the fruit. In summary, our results show conserved functions during gynoecium development and novel roles that enrich knowledge of the SPT gene in fleshy fruits.
Experentia Et Progressus: An Experiential Needs Assessment of Military Health care Providers in Treating Pediatric Combat Trauma
Authors: Tovar Matthew A , Lara Sebastian W , Rudinsky Sherri L , Bibbens Sara E 
Published: January 2025

ABSTRACT

Introduction
Children are among the most vulnerable populations affected by armed conflicts, yet there is limited data on the preparedness of military medical personnel to care for pediatric combat trauma casualties in austere or large-scale combat operations. This study aimed to assess the confidence, training needs, and resource requirements of military medical providers who have managed pediatric patients during deployment.

Materials and Methods
This IRB-exempt, cross-sectional mixed-methods study used a survey created via a modified Delphi method with input from subject matter experts. The survey was distributed to active duty and reservist physicians, nurses, medics, and corpsmen who had previously deployed to combat environments. Respondents answered Likert-style questions anonymously on the SurveyMonkey platform. Data were analyzed using Welch’s t-test, with statistical significance defined as P &lt; .05. Qualitative data were coded into discrete themes and summarized.

Results
A total of 84 respondents participated in the survey. Only 27% reported feeling confident or very confident in resuscitating pediatric casualties. Health care providers with prior exposure to pediatric patients reported significantly higher confidence in pediatric trauma resuscitation (P = .02). Key factors contributing to low confidence included difficulty with pediatric medication dosing, anatomical and physiological differences, lack of experience, and insufficient pediatric-specific equipment during deployment. Nearly all respondents with prior pediatric combat trauma experience expressed a desire for additional pediatric-specific predeployment training, with nearly half (47%) advocating for more robust military-civilian trauma center partnerships. Furthermore, 59% of respondents felt they lacked adequate emotional support following negative pediatric events and recommended stronger post-traumatic event debriefing and support mechanisms.

Conclusions
Many recently deployed military medical providers reported low confidence in resuscitating pediatric patients in the combat environment, because of drug dosing, anatomic and physiologic differences, and inexperience. Regardless of specialty, almost all providers requested additional pediatric training to improve baseline preparedness. These results can guide future predeployment training and inform policy to reduce unnecessary pediatric mortality on the battlefield.
ChIP-mini: a low-input ChIP-exo protocol for elucidating DNA-binding protein dynamics in intracellular pathogens
Authors: Park Joon Young , Jang Minchang , Choi Eunna , Lee Sang-Mok , Bang Ina , Woo Jihoon , Kim Seonggyu , Lee Eun-Jin , Kim Donghyuk 
Published: January 2025

Abstract
Genome-wide identification of binding profiles for DNA-binding proteins from the limited number of intracellular pathogens in infection studies is crucial for understanding virulence and cellular processes but remains challenging, as the current ChIP-exo is designed for high-input bacterial cells (&gt;1010). Here, we developed an optimized ChIP-mini method, a low-input ChIP-exo utilizing a 5,000-fold reduced number of initial bacterial cells and an analysis pipeline, to identify genome-wide binding dynamics of DNA-binding proteins in host-infected pathogens. Applying ChIP-mini to intracellular Salmonella Typhimurium, we identified 642 and 1,837 binding sites of H-NS and RpoD, respectively, elucidating changes in their binding position and binding intensity during infection. Post-infection, we observed 21 significant reductions in H-NS binding at intergenic regions, exposing the promoter region of virulence genes, such as those in Salmonella pathogenicity islands-2, 3 and effectors. Furthermore, we revealed the crucial phenomenon that novel and significantly increased RpoD bindings were found within regions exhibiting diminished H-NS binding, thereby facilitating substantial upregulation of virulence genes. These findings markedly enhance our understanding of how H-NS and RpoD simultaneously coordinate the transcription initiation of virulence genes within macrophages. Collectively, this work demonstrates a broadly adaptable tool that will enable the elucidation of DNA-binding protein dynamics in diverse intracellular pathogens during infection.
Intraoperative Radiotherapy in Brain Metastasis Surgery allows faster Transition to Systemic Therapy
Authors: Krauss Philipp , Wolfert Christina , Bakos Jason , Stemmer Bastian , Stueben Georg , Kahl Klaus Henning , Shiban Ehab 
Published: January 2025

Abstract

Background
In patients with brain metastases BMs, delay of systemic therapy (CTX) after oncologic surgery due to wound healing issues and postoperative radiotherapy might influence the oncologic outcome. Intraoperative radiotherapy (IORT) is an emerging option in neurooncology, possibly shortening the time for comprehensive treatment compared to conventional external beam radiotherapy (EBRT). Aim of this study was to compare the transition time to CTX in patients undergoing IORT or EBRT.

Methods
We performed a retrospective chart review analysis of patients undergoing surgery for BMs at our institution with either IORT or adjuvant EBRT. Either therapy was applied according to an internal standard operation procedure favoring IORT if feasible. The time (days) from surgery until the beginning of CTX was compared together with overall hospitalization time.

Results
99 patients were analyzed from which 59 underwent adjuvant EBRT and 40 IORT. Patients undergoing resection of BMs with IORT had significantly shorter intervals to CTX (EBRT vs. IORT; 65.4 ± 54.3 days vs. 32.3 ± 28.0 days (mean±SD); p &lt; .001). Comparing the interval to CTX between last EBRT fraction and IORT showed no significant difference EBRT vs. IORT (26.2 ± 55.8 days vs. 32.3 ± 28.0 days (mean±SD); p = .52). The time spent hospitalized until CTX was significantly lower in the IORT group (EBRT vs. IORT 20.2 ± 9.4 days vs. 9.5 ± 7.1 days (mean±SD); p &lt;.001).

Conclusion
IORT for BM surgery allows faster transition to systemic oncologic therapy than conventional adjuvant EBRT.
Substitutes for Industrial Trans Fats in Packaged Foods: A Scoping Review
Authors: Barros Beatriz Vasconcellos de , Kraemer Mariana Vieira dos Santos , Milano Elisa , Bernardo Greyce Luci , Chaddad Maria Cecília Cury , Uggioni Paula Lazzarin , Proença Rossana Pacheco da Costa , Fernandes Ana Carolina 
Published: January 2025

Abstract
The World Health Organization recommended the global elimination of industrial trans fats by 2023, leading to a decrease in their use in packaged foods. Nevertheless, a gap remains in the scientific literature regarding the ingredients adopted as substitutes by the food industry. This study aimed to map evidence on substitutes for industrial trans fats in packaged foods, discussing their possible designation in the ingredients lists. For this, a scoping review was conducted according to recommendations from the Joanna Briggs Institute. Systematic searches were performed in 6 databases using terms related to industrial trans fats, identification of possible substitutes, and trans fats exemption. The search retrieved 5072 articles. Of these, 233 (152 original articles and 81 review studies) were included in the scoping review. A total of 87 different raw materials were cited as trans fats substitutes in the selected studies, with palm stearin being the most frequent. The processing methods were categorized in 8 groups, with interesterification being the most cited (46% of studies). Food items belonging to 15 food groups were found to contain trans fats substitutes, mainly margarine, shortenings, and spreads. From the collected data, it was estimated that there are at least 690 distinct terms for referring to industrial trans fats substitutes in the ingredients list. Despite the extensive body of research on the subject, the Codex Alimentarius guidelines and some national labeling regulations do not address the reporting of such materials in the ingredients lists. Furthermore, there is limited understanding of the short- and long-term effects of novel technological ingredients on human health. The disclosure of industrial processes to modify oils and fats, as well as the raw materials used, is suggested to be made mandatory in the ingredients list, aiming to safeguard consumers' right to information and enhance monitoring efforts.
Beyond Food Assistance: A Scoping Review Examining Associations of Nonfood Social Safety Net Programs in the United States With Food Insecurity and Nutrition Outcomes
Authors: Duffy Emily W , Poole Mary Kathryn , Gonzalez David , Petimar Joshua , Kinsey Eliza W , Shafer Paul R , Baldwin-SoRelle Carrie , Austin Anna E 
Published: January 2025

Abstract

Objective
To conduct a scoping review to summarize the state of the evidence on associations between participation in nonfood social safety net programs (eg, income assistance, housing assistance) in the United States and food- and nutrition insecurity–related outcomes.

Background
Food and nutrition insecurity are persistent public health challenges in the United States that increase chronic disease risk and exacerbate health disparities. Several food assistance programs enhance food and nutrition security. Nonfood social safety net programs, however, may also improve these outcomes by relieving households’ financial strain. Understanding the scope of research on nonfood social safety net programs’ associations with not only food insecurity but also nutrition insecurity is needed to understand their potential to reduce the burden of diet-related chronic disease.

Methods
Six databases were systematically searched for peer-reviewed articles. Articles were included if they were published between 1995 and 2023; conducted in the United States; available in English; included a dependent variable of food- and/or nutrition insecurity–related measures; and included an independent variable of participation in a federally funded, nonfood social safety net program.

Results
Included articles (n = 65) reported on studies that examined 10 unique social safety net programs; 8 studies examined program interactions. Twenty studies focused on COVID-19 pandemic-era programs. Fifty-eight studies used food insecurity, food insufficiency, or food hardship as outcomes, and 11 studies used nutrition insecurity–related outcomes. Overall, results suggest that participation in nonfood social safety net programs is associated with reductions in food insecurity. Current evidence for an association between program participation and nutrition insecurity–related outcomes is limited.

Conclusion
Further research is warranted on the association between nonfood social safety net programs and nutrition insecurity; potential interactions between social safety net programs; associations between the expiration of pandemic-era programs and food and nutrition insecurity; and how program impacts might differ among populations with persistent disparities in food and nutrition insecurity.
The disclosure of information about trusts: The common law and how it has evolved and been modified by legislation in various countries
Authors: Brandts-Giesen Henry , Boock Samira 
Published: January 2025

Abstract
The disclosure of trust information to beneficiaries is a contentious topic. The issue of whether and what information about a trust is disclosed to beneficiaries has vexed trustees and judges for decades. The common law has evolved over centuries. Lawmakers in some jurisdictions have prescribed their own rules. This article examines the conflicting duties of confidentiality and accountability.
‘I am very sensitive on the subject of accent’: Children, young people and attitudes to speech in inter-war Britain
Authors: Barron Hester 
Published: January 2025

Abstract
This article considers elite and popular attitudes to speech and accent in inter-war Britain, specifically with regard to children and young people. It begins by showing that speech was a consistent preoccupation of educationalists, for whom classed prejudices complemented more progressive concerns about citizenship and employment. It continues by considering everyday school practices, charting the ways in which schools tried to influence their pupils’ speech. Efforts were often variable—and Mass-Observation accounts show that teachers’ attitudes were not always consistent either—but children might respond positively nonetheless. Finally, it considers influences external to school such as family attitudes, the wireless, and the cinema, showing that concerns with speech and language were not limited to an educational hierarchy but were often shared by working-class parents and sometimes children themselves. The article thus suggests that there was less of a difference between official attitudes and the (literal and metaphorical) vernacular than is and was often assumed. It argues that widespread attention to speech and language was one way in which social and educational aspirations were fostered amidst the new technologies, consumerism, and democracy of inter-war Britain.