bluuebunny/crossref_metadata_2025_split huggingface dataset:
First principle study of ATiO$$_3$$ (A=Ti,Sr) materials for photovoltaic applications
Authors: Allan Lynet , Mulwa Winfred M. , Mapasha R. E. , Mwabora Julius M. , Musembi Robinson J. 
Published: January 2024

Abstract
Context
The study investigates the impact of Hubbard U correction and spin-orbit coupling (SOC) on the structural, mechanical, electronic, and optical properties of $$\text {Ti}_{2}\textrm{O}_{3}$$

Ti
2

O
3

and $$\text {SrTiO}_{3}$$

SrTiO
3

compounds. The research is motivated by the potential applications of these materials in photovoltaics, with a focus on understanding their properties for such use. The ductility, ionicity, and mechanical stability of both compounds at zero pressure are assessed, indicating their potential as resilient materials. Also, the compounds display high refractive indices and absorption coefficients, indicating their suitability for solar harvesting applications. The predicted bandgaps align primarily with the UV–Vis areas of the electromagnetic spectrum, highlighting their potential in this domain.

Methods
Computational techniques employed in this study are density functional theory (DFT) with and without spin-orbit coupling, as well as DFT+U methods, implemented using the Quantum ESPRESSO (QE) package. The study adopts the Perdew-Burke-Ernzerhof (PBE) exchange-correlation functional, while employing a plane-wave basis set with an energy cutoff of 50 Ry for wavefunctions and 500 Ry for charge density.
Analytic regularity and solution approximation for a semilinear elliptic partial differential equation in a polygon
Authors: He Yanchen , Schwab Christoph 
Published: January 2024

AbstractIn an open, bounded Lipschitz polygon $$\Omega \subset \mathbb {R}^2$$

Ω
⊂

R

2

, we establish weighted analytic regularity for a semilinear, elliptic PDE with analytic nonlinearity and subject to a source term f which is analytic in $$\Omega $$
Ω
. The boundary conditions on each edge of $$\partial \Omega $$

∂
Ω

are either homogeneous Dirichlet or homogeneous Neumann BCs. The presently established weighted analytic regularity of solutions implies exponential convergence of various approximation schemes: hp-finite elements, reduced order models via Kolmogorov n-widths of solution sets in $$H^1(\Omega )$$

H
1

(
Ω
)

, quantized tensor formats and certain deep neural networks.
ETV7 promotes colorectal cancer progression through upregulation of IFIT3
Authors: Chai Bao , Li Yanjun , Guo Yarong , Zhang Zhuowei , Jia Kai , Chai Xinhao , Suo Yuhong 
Published: January 2024

AbstractMembers of the E26 transformation-specific (ETS) variant transcription factor family act as either tumor suppressors or oncogenic factors in numerous types of cancer. ETS variant transcription factor 7 (ETV7) participates in the development of malignant tumors, whereas its involvement in colorectal cancer (CRC) is less clear. In this study, The Cancer Genome Atlas (TCGA) and immunochemistry staining were applied to check the clinical relevance of ETV7 and interferon-induced protein with tetratricopeptide repeats 3 (IFIT3) in CRC patients. Overexpression and knockdown of ETV7 and IFIT3 were conducted by transfecting the cells with pCDNA3.1 plasmids and siRNAs, respectively. Western blotting was used to detect the protein expression of ETV7 in CRC cells. Cell Counting Kit-8, cell colony formation, and Transwell assays, as well as flow cytometry, were used to evaluate the proliferation, migration, cell cycle, and apoptosis of CRC cells. Furthermore, western blotting, RT-qPCR, and luciferase assay were used to explore the regulation of ETV7 on IFIT3. Rescue assay was used to investigate the significance of ETV7/IFIT3 axis on CRC progression. We found that ETV7 was upregulated in CRC tissues and cells. Overexpression of ETV7 stimulated the proliferation, migration, and cell cycle amplification, and reduced the apoptosis of CRC cells. Downregulation of ETV7 exerted the opposite effect on CRC cell progression. Moreover, we demonstrated that ETV7 stimulated the transcription activity, the mRNA and protein expression of IFIT3 in CRC cells. There was a positive correlation between ETV7 and IFIT3 in CRC patients. IFIT3 knockdown reversed the promotive effect exerted by overexpression of ETV7 on the amplification and migration of CRC cells. By contrast, overexpression of IFIT3 blocked the inhibitory effect of ETV7-targeting siRNA. In summary, ETV7 induces progression of CRC by activating the transcriptional expression of IFIT3. The EVT7/IFIT3 axis may be a novel target for CRC therapy.
Screening for precancerous anal lesions linked to human papillomaviruses: French recommendations for clinical practice
Authors: Spindler L. , Etienney I. , Abramowitz L. , de Parades V. , Pigot F. , Siproudhis L. , Adam J. , Balzano V. , Bouchard D. , Bouta N. , Bucau M. , Carlo A. , Chanal J. , Charpentier C. , Clifford G. , Draullette M. , Fathallah N. , Ferré V. , Fléjou J.-F. , Fouéré S. , Higuero T. , Kassouri L. , Kurt S. , Laurain A. , Leclerc E. , Lepiller Q. , Lesage A.-C. , Mège D. , Ménard A. , Merle P. , Mortreux P. , Noël C. , Péré H. , Prétet J.-L. , Roland D. , Staumont G. , Tracanelli L. , Vuitton L. , Wylomanski S. , Zaegel-Faucher O. ,   Société Nationale Française de Colo-Proctologie
Published: January 2024

AbstractIn France, about 2000 new cases of anal cancer are diagnosed annually. Squamous cell carcinoma is the most common histological type, mostly occurring secondary to persistent HPV16 infection. Invasive cancer is preceded by precancerous lesions. In addition to patients with a personal history of precancerous lesions and anal cancer, three groups are at very high risk of anal cancer: (i) men who have sex with men and are living with HIV, (ii) women with a history of high-grade squamous intraepithelial lesions (HSILs) or vulvar HPV cancer, and (iii) women who received a solid organ transplant more than 10 years ago. The purpose of screening is to detect HSILs so that they can be treated, thereby reducing the risk of progression to cancer. All patients with symptoms should undergo a proctological examination including standard anoscopy. For asymptomatic patients at risk, an initial HPV16 test makes it possible to target patients at risk of HSILs likely to progress to cancer. Anal cytology is a sensitive test for HSIL detection. Its sensitivity is greater than 80% and exceeds that of proctological examination with standard anoscopy. It is indicated in the event of a positive HPV16 test. In the presence of cytological abnormalities and/or lesions and a suspicion of dysplasia on clinical examination, high-resolution anoscopy is indicated. Performance is superior to that of proctological examination with standard anoscopy. However, this technique is not widely available, which limits its use. If high-resolution anoscopy is not possible, screening by a standard proctological examination is an alternative. There is a need to develop high-resolution anoscopy and triage tests and to evaluate screening strategies.
A systematic literature review on business-IT misalignment research
Authors: Őri Dóra , Szabó Zoltán 
Published: January 2024

AbstractThere has been a large body of research on strategic alignment between business and information technology, which has also been summarised in several literature reviews. All of these studies describe that business-IT alignment has remained a focal point among business and IT leaders. However, little is known about a specific perspective, namely, on business-IT misalignment, on which, although some analytical works have been carried out over the last twenty years, no literature review has been summarised. The purpose of this article is to display and analyze relevant literature regarding business-IT misalignment and map the influential issues by conducting a systematic literature review. This study collected in sum 642 papers published from the Scopus and Google Scholar databases. Finally, 62 articles were selected for the systematic review. The study examined eight research questions for business-IT misalignment derived from recent, high-impact business-IT alignment literature reviews. Results are analyzed qualitatively to find a better understanding of the current body of knowledge in business-IT misalignment and to provide a research agenda.
CT-Based Intratumoral and Peritumoral Radiomics Nomograms for the Preoperative Prediction of Spread Through Air Spaces in Clinical Stage IA Non-small Cell Lung Cancer
Authors: Wang Yun , Lyu Deng , Hu Lei , Wu Junhong , Duan Shaofeng , Zhou Taohu , Tu Wenting , Xiao Yi , Fan Li , Liu Shiyuan 
Published: January 2024

AbstractThe study aims to investigate the value of intratumoral and peritumoral radiomics and clinical-radiological features for predicting spread through air spaces (STAS) in patients with clinical stage IA non-small cell lung cancer (NSCLC). A total of 336 NSCLC patients from our hospital were randomly divided into the training cohort (n = 236) and the internal validation cohort (n = 100) at a ratio of 7:3, and 69 patients from the other two external hospitals were collected as the external validation cohort. Univariate and multivariate analyses were used to select clinical-radiological features and construct a clinical model. The GTV, PTV5, PTV10, PTV15, PTV20, GPTV5, GPTV10, GPTV15, and GPTV20 models were constructed based on intratumoral and peritumoral (5 mm, 10 mm, 15 mm, 20 mm) radiomics features. Additionally, the radscore of the optimal radiomics model and clinical-radiological predictors were used to construct a combined model and plot a nomogram. Lastly, the ROC curve and AUC value were used to evaluate the diagnostic performance of the model. Tumor density type (OR = 6.738) and distal ribbon sign (OR = 5.141) were independent risk factors for the occurrence of STAS. The GPTV10 model outperformed the other radiomics models, and its AUC values were 0.887, 0.876, and 0.868 in the three cohorts. The AUC values of the combined model constructed based on GPTV10 radscore and clinical-radiological predictors were 0.901, 0.875, and 0.878. DeLong test results revealed that the combined model was superior to the clinical model in the three cohorts. The nomogram based on GPTV10 radscore and clinical-radiological features exhibited high predictive efficiency for STAS status in NSCLC.
Robustness of Deep Networks for Mammography: Replication Across Public Datasets
Authors: Velarde Osvaldo M. , Lin Clarissa , Eskreis-Winkler Sarah , Parra Lucas C. 
Published: January 2024

AbstractDeep neural networks have demonstrated promising performance in screening mammography with recent studies reporting performance at or above the level of trained radiologists on internal datasets. However, it remains unclear whether the performance of these trained models is robust and replicates across external datasets. In this study, we evaluate four state-of-the-art publicly available models using four publicly available mammography datasets (CBIS-DDSM, INbreast, CMMD, OMI-DB). Where test data was available, published results were replicated. The best-performing model, which achieved an area under the ROC curve (AUC) of 0.88 on internal data from NYU, achieved here an AUC of 0.9 on the external CMMD dataset (N = 826 exams). On the larger OMI-DB dataset (N = 11,440 exams), it achieved an AUC of 0.84 but did not match the performance of individual radiologists (at a specificity of 0.92, the sensitivity was 0.97 for the radiologist and 0.53 for the network for a 1-year follow-up). The network showed higher performance for in situ cancers, as opposed to invasive cancers. Among invasive cancers, it was relatively weaker at identifying asymmetries and was relatively stronger at identifying masses. The three other trained models that we evaluated all performed poorly on external datasets. Independent validation of trained models is an essential step to ensure safe and reliable use. Future progress in AI for mammography may depend on a concerted effort to make larger datasets publicly available that span multiple clinical sites.
CTG18.1 expansion in transcription factor 4 (TCF4) in corneal graft failure: preliminary study
Authors: Westin Ida Maria , Viberg Andreas , Golovleva Irina , Byström Berit 
Published: January 2024

AbstractFuchs endothelial corneal dystrophy (FECD) is caused by a corneal endothelial cell loss, leading to corneal edema and visual impairment. The most significant genetic risk factor for FECD is an expansion of the CTG18.1 locus in transcription factor 4 (TCF4). The current treatment for severe FECD is corneal transplantation, with Descemet stripping automated keratoplasty (DSAEK) as a common surgical method. Although successful in most cases, the risk for transplant failure due to diverse causes must be considered. In this study, we investigated if presence of TCF4 CTG18.1 expansion with more than 31 (n ≥ 31) repeats in donated corneal grafts could be a reason for corneal transplant failure after DSAEK. For this, nine consecutively failed DSAEK corneal grafts were genotyped for CTG18.1 repeat length. One-sided Mann–Whitney U test was performed to evaluate if failed DSAEK corneal grafts had longer CTG18.1 repeats than healthy controls from the same population. All failed corneal grafts had CTG18.1 n ≤ 27 with a median of 18 (IQR 8.0) repeats for the longest allele. There was no statistical difference in CTG18.1 repeat lengths between failed corneal grafts and the geographically matched healthy control group. In conclusion, none of the nine failed corneal grafts in our material had CTG18.1 repeat lengths ≥ 31, a cut-off known to have a biological relevance in FECD. Thus, our results suggest that the assessment of donors and inspection of the corneal tissue before the decision for procurement is sufficient, in terms of recognizing FECD in the donor.
Phenotypic diversity analysis of Polygala tenuifolia Willd germplasm resources in China
Authors: Tian Hongling , Wu Changjuan , Zhang Lijun , Guo Shuhong , Wang Yaoqin , Pei Shuaishuai , Zuo Xianqiang , Wang Qiubao , Zhang Qiang 
Published: January 2024

AbstractPolygala tenuifolia Willd is a perennial herb in the family Polygalaceae and is used as an expectorant and stimulant in traditional Chinese medicine. There is a large demand for P. tenuifolia, while the good cultivars of P. tenuifolia are not enough. In this study, we collected 157 germplasm resources of P. tenuifolia from different regions in China, and 12 phenotypic traits of these samples were analyzed using correlation analysis, principal component analysis (PCA), and cluster analysis methods. The correlation analysis showed the associations between different traits, and the first four principal components contributed 62.63% of the total variation. They contained most of the information of five above-ground traits and eight root traits. Phylogenetic clustering divided materials divided into four taxa, with characteristics of high-yielding specific material, long-rooted specific material, multi-branching specific material, and high plant height specific material, respectively. Our study provides the material and theoretical basis for the utilization of germplasm resources, parental selection, and varietal improvement of P. tenuifolia.
He Taonga Te Wareware: Connecting Older Māori Experiences of Wairuatanga with Mate Wareware (Dementia)
Authors: Te Maringi Mai o Hawaiiki  , Menzies Oliver , Garrett Nick , Dudley Makarena 
Published: January 2024

AbstractMate wareware (dementia) is a complex disease of the brain that progressively inhibits memory and cognitive ability, affecting many Māori (the Indigenous people of Aotearoa New Zealand) kaumātua (elderly persons) in Aotearoa (New Zealand). Mate wareware care aims to protect and sustain wellbeing, yet Māori perspectives of wellbeing that consider wairuatanga (Māori spirituality) are often neglected within current treatment planning. This study investigates the presence of wairuatanga within kaumātua lives, drawing upon 61 interviews with kaumātua to glean a Māori understanding of mate wareware and to develop a diagnostic screening tool for mate wareware. Recorded responses were thematically analysed using reflexive qualitative analysis, informing four key themes that influence wairuatanga: he hononga tangata (social connection), tūrangawaewae (places of connection), tuakiritanga (identity) and mahi mauritau (mindful practices). These themes consider the value of creating rich and gratifying lifestyles for kaumātua that cultivate their spiritual wellbeing. This study validates diverse understandings and experiences of wairuatanga as essential to Māori wellbeing, affirming the relevance of wairuatanga to improve outcomes for Māori living with mate wareware.
A proposed index of myocardial staining for vein of Marshall ethanol infusion: an Italian single-center experience
Authors: Landra Federico , Nesti Martina , Garibaldi Silvia , Mirizzi Gianluca , Startari Umberto , Panchetti Luca , Piacenti Marcello , Taddeucci Simone , Formichi Bruno Antonio , Stefani Maurizio , Galiberti Serena , Lionetti Vincenzo , Solinas Paolo , Levantesi Beatrice Maria , Italia Chiara , Rossi Andrea 
Published: January 2024

Abstract
Background
Mitral isthmus (MI) conduction block is a fundamental step in anatomical approach treatment for persistent atrial fibrillation (PeAF). However, MI block is hardly achievable with endocardial ablation only. Retrograde ethanol infusion (EI) into the vein of Marshall (VOM) facilitates MI block. Fluorographic myocardial staining (MS) during VOM-EI could be helpful in predicting procedural alcoholization outcome even if its role is qualitatively assessed in the routine. The aim was to quantitatively assess MS during VOM-EI and to evaluate its association with MI block achievement.

Methods
Consecutive patients undergoing catheter ablation for PeAF at Fondazione Toscana Gabriele Monasterio (Pisa, Italy) from February 2022 to May 2023 were considered. Patients with identifiable VOM were included. A proposed index of MS (MSI) was retrospectively calculated in each included patient. Correlation of MSI with low-voltage zones (LVZ) extension after VOM-EI and its association with MI block achievement were assessed.

Results
In total, 42 patients out of 49 (85.8%) had an identifiable VOM. MI block was successfully achieved in 35 patients out of 42 (83.3%). MSI was significantly associated with the occurrence of MI block (OR 1.24 (1.03–1.48); p = 0.022). A higher MSI resulted in reduced ablation time (p = 0.014) and reduced radiofrequency applications (p = 0.002) to obtain MI block. MSI was also associated with MI block obtained by endocardial ablation only (OR 1.07 (1.02–1.13); p = 0.002). MSI was highly correlated with newly formed LVZ extension (r = 0.776; p = 0.001).

Conclusions
In our study cohort, optimal MSI predicts MI block and facilitates its achievement with endocardial ablation only.
Surface characteristics and in vitro biocompatibility of titanium preserved in a vitamin C-containing saline storage solution
Authors: Zhang Wen-si , Liu Yao , Shao Shui-Yi , Shu Chang-qing , Zhou Yi-heng , Zhang Song-mei , Qiu Jing 
Published: January 2024

AbstractThe purpose of this study is to explore a storage solution for titanium implants and investigate its osteogenic properties. The commercial pure titanium (cp-Ti) surface and double-etched (SLA) titanium surface specimens were preserved in air, saline, 10 mM Vitamin C (VitC)-containing saline and 100 mM VitC-containing saline storage solutions for 2 weeks. The surface microtopography of titanium was observed by scanning electron microscopy (SEM), the surface elemental compositions of the specimens were analyzed by Raman and X-ray photoelectron spectroscopy (XPS), and water contact angle and surface roughness of the specimens were tested. The protein adsorption capacity of two titanium surfaces after storage in different media was examined by BCA kit. The MC3T3-E1 osteoblasts were cultured on two titanium surfaces after storage in different media, and the proliferation, adhesion and osteogenic differentiation activity of osteoblasts were detected by CCK-8, laser confocal microscope (CLSM) and Western blot. The SEM results indicated that the titanium surfaces of the air group were relatively clean while scattered sodium chloride or VitC crystals were seen on the titanium surfaces of the other three groups. There were no significant differences in the micromorphology of the titanium surfaces among the four groups. Raman spectroscopy detected VitC crystals on the titanium surfaces of two experimental groups. The XPS, water contact angle and surface roughness results suggested that cp-Ti and SLA-Ti stored in 0.9% NaCl and two VitC-containing saline storage solutions possessed less carbon contamination and higher surface hydrophilicity. Moreover, the protein adsorption potentials of cp-Ti and SLA-Ti surfaces were significantly improved under preservation in two VitC-containing saline storage solutions. The results of in vitro study showed that the preservation of two titanium surfaces in 100 mM VitC-containing saline storage solution upregulated the cell adhesion, proliferation, osteogenic related protein expressions of MC3T3-E1 osteoblasts. In conclusion, preservation of cp-Ti and SLA-Ti in 100 mM VitC-containing saline storage solution could effectively reduce carbon contamination and enhance surface hydrophilicity, which was conducive to osteogenic differentiation of osteoblasts.
Graphical Abstract
A Bayesian Aoristic Logistic Regression to Model Spatio-Temporal Crime Risk Under the Presence of Interval-Censored Event Times
Authors: Briz-Redón Álvaro 
Published: January 2024

Abstract
Purpose
Crime data analysis has gained significant interest due to its peculiarities. One key characteristic of property crimes is the uncertainty surrounding their exact temporal location, often limited to a time window.

Methods
This study introduces a spatio-temporal logistic regression model that addresses the challenges posed by temporal uncertainty in crime data analysis. Inspired by the aoristic method, our Bayesian approach allows for the inclusion of temporal uncertainty in the model.

Results
To demonstrate the effectiveness of our proposed model, we apply it to both simulated datasets and a dataset of residential burglaries recorded in Valencia, Spain. We compare our proposal with a complete cases model, which excludes temporally-uncertain events, and also with alternative models that rely on imputation procedures. Our model exhibits superior performance in terms of recovering the true underlying crime risk.

Conclusions
The proposed modeling framework effectively handles interval-censored temporal observations while incorporating covariate and space–time effects. This flexible model can be implemented to analyze crime data with uncertainty in temporal locations, providing valuable insights for crime prevention and law enforcement strategies.
Effect of a Spiritual Care Training Program to Build Knowledge, Competence, Confidence and Self-awareness Among Australian Health and Aged Care Staff: An Exploratory Study
Authors: Jones Kate F. , Kearney Matthew , Best Megan C. 
Published: January 2024

AbstractThe aim of this study was to evaluate a new spiritual care training program with health and aged care staff. A four-module program was delivered to 44 participants at a large Catholic health and aged care provider in Australia. Pre, post and 6 week follow-up surveys were administered and included measures of spiritual care competency, confidence, perspectives of spirituality and spiritual care, spiritual well-being, and satisfaction. Paired sample t-tests showed total scores of participants’ spiritual well-being, spiritual care competency and confidence significantly improved following the training and were largely maintained at follow-up. Perspectives on spirituality and spiritual care did not significantly change over time.