bluuebunny/crossref_metadata_2025_split huggingface dataset:
A generalized Darbo’s fixed point theorem and its applications to different types of hybrid differential equations
Authors: Das Anupam , Deb Sudip , Goswami Rupanjali , Ahmed Tazuddin , Izadi Zeynab , Parvaneh Vahid 
Published: November 2023

AbstractIn this article, a generalization of Darbo’s fixed point theorem using a new contraction operator is obtained to solve our proposed hybrid differential and fractional hybrid differential equations in a Banach space. The applicability of our results with the help of a suitable example has also been shown.
Exploring the health literacy status of people with hearing impairment: a systematic review
Authors: Piao Zhaoyan , Lee Hanbin , Mun Yeongrok , Lee Hankil , Han Euna 
Published: November 2023

Abstract
Background
People with hearing impairment have many problems with healthcare use, which is associated with health literacy. Research on health literacy is less focused on people with hearing impairments. This research aimed to explore the levels of health literacy in people with hearing impairment, find the barriers to health literacy, and summarize methods for improving health literacy.

Methods
A systematic review was conducted using three databases (PubMed, Cochrane, and Embase) to search the relevant articles and analyze them. The studies were selected using pre-defined inclusion/exclusion criteria in two steps: first, selection by examining the title and abstract; and second, after reading the study in full. The Risk of Bias Assessment Tool for Nonrandomized Studies (RoBANS) was used to assess the quality of the articles.

Results
Twenty-nine studies were synthesized qualitatively. Individuals with hearing impairment were found to have lower health literacy, when compared to those without impairment, which can lead to a higher medical cost. Most of the people with hearing impairment faced barriers to obtaining health-related information and found it difficult to communicate with healthcare providers. To improve their health literacy, it is essential to explore new ways of accessing health information and improving the relationship between patients and healthcare providers.

Conclusions
Our findings show that people with hearing impairment have lower health literacy than those without. This suggests that developing new technology and policies for people with hearing impairment is necessary not to mention promoting provision of information via sign language.

Trial registration
OSF: https://doi.org/10.17605/OSF.IO/V6UGW. PROSPERO ID: CRD42023395556.
Social protection as a right of people affected by tuberculosis: a scoping review and conceptual framework
Authors: Ferreira Melisane Regina Lima , Bonfim Rafaele Oliveira , Bossonario Pedro Augusto , Maurin Venisse Paschoalin , Valença Ana Beatriz Marques , Abreu Paula Daniella de , Andrade Rubia Laine de Paula , Fronteira Inês , Monroe Aline Aparecida 
Published: November 2023

Abstract
Background
Tuberculosis is an infectious disease strongly influenced by social determinants closely associated with cycles of poverty and social exclusion. Within this context, providing social protection for people affected by the disease constitutes a powerful instrument for reducing inequalities and enhancing inclusion and social justice. This study aimed to identify and synthesize strategies and measures aimed at ensuring social protection as a right of people affected by tuberculosis.

Methods
This is a scoping review, with searches conducted in six databases in February 2023. We included publications from 2015 onwards that elucidate strategies and measures of social protection aimed at safeguarding the rights to health, nutrition, employment, income, housing, social assistance, and social security for people affected by tuberculosis. These strategies could be implemented through policies, programs, and/or governmental agreements in any given context. The data extracted from the articles underwent descriptive analysis and a narrative synthesis of findings based on the dimensions of social protection. Additionally, we developed a conceptual framework illustrating the organizational and operational aspects of measures and strategies related to each dimension of social protection identified in this review.

Results
A total of 9317 publications were retrieved from the databases, of which sixty-three publications were included. The study’s results highlighted measures and strategies concerning the social protection of people affected by tuberculosis. These measures and strategies revolved around the rights to proper nutrition and nourishment, income, housing, and health insurance, as well as expanded rights encompassing social assistance and social welfare. It was reported that ensuring these rights contributes to improving nutritional status and the quality of life for individuals with tuberculosis, along with reducing catastrophic costs, expanding access to healthcare interventions and services, and fostering TB treatment adherence, thereby leading to higher rates of TB cure.

Conclusions
Our findings identify social protection measures as a right for people affected by tuberculosis and have the potential to guide the development of evidence-based social and health policies through collaboration between tuberculosis control programs and governmental entities.
Biostimulants promoting growth of Vicia faba L. seedlings: inulin coated ZnO nanoparticles
Authors: Carbone Marilena , De Rossi Silvia , Donia Domenica Tommasa , Di Marco Gabriele , Gustavino Bianca , Roselli Ludovica , Tagliatesta Pietro , Canini Antonella , Gismondi Angelo 
Published: November 2023

AbstractIn the present contribution, inulin coated ZnO nanoparticles (ZnO@inu NPs) were investigated for their potential application on crop production systems, by appraisal of their biostimulating effects on Vicia faba L (faba bean). Naked and coated ZnO NPs were synthesized according to purposely implemented eco-friendly protocols and characterized with multiple techniques to determine their crystallographic phase, average particle size, and degree of coating. Faba beans were grown in culture medium supplemented with NPs at 50 or 100 mg kg−1, using ZnO NPs alone, inulin alone, a mixture of the two, or ZnO@inu NPs. Seed germination rate and biometric evaluations on seedlings were carried out, together with Zn localization in the plant tissues. Cellular and molecular effects were ascertained by analyses of photosynthetic pigments, cytotoxicity, genotoxicity, viability, induction of oxidative stress and tissue damage, antioxidant response, and modulation of gene expression. These combined studies indicated a potential role of ZnO@inu NPs in promoting growth and development of V. faba seedlings, acting at a post-germinative phase, probably by stimulating the stem cell mitosis. Finally, inulin as a coating agent for the ZnO NPs favored the bioavailability and adsorption of the nanomaterials into the plant tissues, without altering their bioactivity but mitigating any adverse side effect.
Graphical Abstract
Comparison of postoperative isokinetic quadriceps and gluteal muscular strength after primary THA: is there an early benefit through enhanced recovery programs?
Authors: Reinhard Jan , Schreiner Annika , Dullien Silvia , Götz Julia Sabrina , Leiss Franziska , Maderbacher Günther , Grifka Joachim , Greimel Felix 
Published: November 2023

AbstractPurposeAlthough total hip arthroplasty (THA) is expected to result in a postoperative loss of muscular strength, no study investigated the benefit of an enhanced‐recovery‐after‐surgery (ERAS) concept on the hip muscles in detail. We evaluated if (1) an ERAS‐concept for primary THA results in reduced loss of muscular strength five days and four weeks postoperative. We (2) compared the two groups regarding Patient‐Related‐Outcome‐Measures (PROMs), WOMAC‐index (Western‐Ontario‐and‐McMaster‐Universities‐Osteoarthritis‐Index), HHS (Harris‐Hip‐Score) and EQ‐5d‐3L‐score.MethodsIn a prospective, single‐blinded, randomized controlled trial, we compared isokinetic muscular strength of 24 patients receiving primary THA with an enhanced recovery concept with early mobilization (n = 12, ERAS‐group) and such receiving conventional THA (n = 12, non‐ERAS). Isokinetic muscular strength was measured with a Biodex‐Dynamometer before, as well as five days and four weeks after surgery (peak‐torque, total‐work, power). Furthermore, WOMAC, HHS, PROMs and EQ‐5d‐3L were imposed.ResultsThe ERAS group revealed significant higher isokinetic strength (peak‐torque, total‐work, power) at both time points. Both groups showed a significant pain decrease at both time points meeting very high rates of patient satisfaction resembled by good results in PROMs, WOMAC, HHS, EQ‐5d. There was no significant difference in any of the scores between both groups.ConclusionWe proved a significant reduced loss of muscular strength five days and four weeks after primary THA in combination with an ERAS concept. However, the reduced loss of muscular strength is not reflected by patient’s functional outcome and quality of life, showing no significant differences in WOMAC, HHS, EQ‐5d‐3L, PROMs and NRS. Therefore, this study supports the implementation of an ERAS concept for primary THA in terms of isokinetic strength. Further studies are needed to evaluate the development of muscular strength over a long period.
Achieving safe and high-performance gastrointestinal tract spectral CT imaging with small-molecule lanthanide complex
Authors: Che Xiaoling , Yang Chunmei , Pan Liping , Gu Didi , Dai Guidong , Shu Jian , Yang Lu 
Published: November 2023

Abstract

Background
Non-intrusive imaging of gastrointestinal (GI) tract using computed tomography (CT) contrast agents is of the most significant issues in the diagnosis and treatment of GI diseases. Moreover, spectral CT, which can generate monochromatic images to display the X-ray attenuation characteristics of contrast agents, provides a better imaging sensitivity for diagnose inflammatory bowel disease (IBD) than convention CT imaging.

Methods
Herein, a convenient and one-pot synthesis method is provided for the fabrication of small-molecule lanthanide complex Holmium-tetraazacyclododecane-1, 4, 7, 10-tetraacetic acid (Ho-DOTA) as a biosafe and high-performance spectral CT contrast agent for GI imaging with IBD. In vivo CT imaging was administered with both healthy mice and colitis mice induced by dextran sodium sulfate.

Results
We found that Ho-DOTA accumulated in inflammation sites of large intestines and produced high CT contrast compared with healthy mice. Both in vitro and in vivo experimental results also showed that Ho-DOTA provided much more diagnostic sensitivity and accuracy due to the excellent X-ray attenuation characteristics of Ho-DOTA compared with clinical iodinate agent. Furthermore, the proposed contrast media could be timely excreted from the body via the urinary and digestive system, keeping away from the potential side effects due to long-term retention in vivo.

Conclusion
Accordingly, Ho-DOTA with excellent biocompatibility can be useful as a potential high-performance spectral CT contrast agent for further clinical imaging of gastrointestinal tract and diagnosis of intestinal system diseases.

Graphical Abstract
Detection of in vivo mutagenicity in rat liver samples using error-corrected sequencing techniques
Authors: Izawa Kazuki , Tsuda Masataka , Suzuki Takayoshi , Honma Masamitsu , Sugiyama Kei-ichi 
Published: November 2023

Abstract
Background
Mutagenicity, the ability of chemical agents to cause mutations and potentially lead to cancer, is a critical aspect of substance safety assessment for protecting human health and the environment. Metabolic enzymes activate multiple mutagens in living organisms, thus in vivo animal models provide highly important information for evaluating mutagenicity in human. Rats are considered suitable models as they share a similar metabolic pathway with humans for processing toxic chemical and exhibit higher responsiveness to chemical carcinogens than mice. To assess mutagenicity in rats, transgenic rodents (TGRs) are widely used for in vivo gene mutation assays. However, such assays are labor-intensive and could only detect transgene mutations inserted into the genome. Therefore, introducing a technology to directly detect in vivo mutagenicity in rats would be necessary. The next-generation sequencing (NGS) based error-corrected sequencing technique is a promising approach for such purposes.

Results
We investigated the applicability of paired-end and complementary consensus sequencing (PECC-Seq), an error-corrected sequencing technique, for detecting in vivo mutagenicity in the rat liver samples. PECC-Seq allows for the direct detection of ultra-rare somatic mutations in the genomic DNA without being constrained by the genomic locus, tissue, or organism. We tested PECC-Seq feasibility in rats treated with diethylnitrosamine (DEN), a mutagenic compound. Interestingly, the mutation and mutant frequencies between PECC-Seq and the TGR assay displayed a promising correlation. Our results also demonstrated that PECC-Seq could successfully detect the A:T > T:A mutation in rat liver samples, consistent with the TGR assay. Furthermore, we calculated the trinucleotide mutation frequency and proved that PECC-Seq accurately identified the DEN treatment-induced mutational signatures.

Conclusions
Our study provides the first evidence of using PECC-Seq for in vivo mutagenicity detection in rat liver samples. This approach could provide a valuable alternative to conventional TGR assays as it is labor- and time-efficient and eliminates the need for transgenic rodents. Error-corrected sequencing techniques, such as PECC-Seq, represent promising approaches for enhancing mutagenicity assessment and advancing regulatory science.
Optimized, automated and cGMP-compliant synthesis of the HER2 targeting [68Ga]Ga-ABY-025 tracer
Authors: Jussing Emma , Ferrat Mélodie , Moein Mohammad M. , Alfredéen Henrik , Tegnebratt Tetyana , Bratteby Klas , Samén Erik , Feldwisch Joachim , Altena Renske , Axelsson Rimma , Tran Thuy A. 
Published: November 2023

Abstract
Background
The Affibody molecule, ABY-025, has demonstrated utility to detect human epidermal growth factor receptor 2 (HER2) in vivo, either radiolabelled with indium-111 (111In) or gallium-68 (68Ga). Using the latter, 68Ga, is preferred due to its use in positron emission tomography with superior resolution and quantifying capabilities in the clinical setting compared to 111In. For an ongoing phase II study (NCT05619016) evaluating ABY-025 for detecting HER2-low lesions and selection of patients for HER2-targeted treatment, the aim was to optimize an automated and cGMP-compliant radiosynthesis of [68Ga]Ga-ABY-025.
[68Ga]Ga-ABY-025 was produced on a synthesis module, Modular-Lab PharmTracer (Eckert & Ziegler), commonly used for 68Ga-labelings. The radiotracer has previously been radiolabeled on this module, but to streamline the production, the method was optimized. Steps requiring manual interactions to the radiolabeling procedure were minimized including a convenient and automated pre-concentration of the 68Ga-eluate and a simplified automated final formulation procedure. Every part of the radiopharmaceutical production was carefully developed to gain robustness and to avoid any operator bound variations to the manufacturing. The optimized production method was successfully applied for 68Ga-labeling of another radiotracer, verifying its versatility as a universal and robust method for radiosynthesis of Affibody-based peptides.

Results
A simplified and optimized automated cGMP-compliant radiosynthesis method of [68Ga]Ga-ABY-025 was developed. With a decay corrected radiochemical yield of 44 ± 2%, a radiochemical purity (RCP) of 98 ± 1%, and with an RCP stability of 98 ± 1% at 2 h after production, the method was found highly reproducible. The production method also showed comparable results when implemented for radiolabeling another similar peptide.

Conclusion
The improvements made for the radiosynthesis of [68Ga]Ga-ABY-025, including introducing a pre-concentration of the 68Ga-eluate, aimed to utilize the full potential of the 68Ge/68Ga generator radioactivity output, thereby reducing radioactivity wastage. Furthermore, reducing the number of manually performed preparative steps prior to the radiosynthesis, not only minimized the risk of potential human/operator errors but also enhanced the process’ robustness. The successful application of this optimized radiosynthesis method to another similar peptide underscores its versatility, suggesting that our method can be adopted for 68Ga-labeling radiotracers based on Affibody molecules in general.
Trial registration: NCT, NCT05619016, Registered 7 November 2022, https://clinicaltrials.gov/study/NCT05619016?term=HER2&cond=ABY025&rank=1
To see or not to see: the parallel processing of self-relevance and facial expressions
Authors: Liu Tuo , Sui Jie , Hildebrandt Andrea 
Published: November 2023

AbstractThe self, like the concept of central "gravity", facilitates the processing of information that is directly relevant to the self. This phenomenon is known as the self-prioritization effect. However, it remains unclear whether the self-prioritization effect extends to the processing of emotional facial expressions. To fill this gap, we used a self-association paradigm to investigate the impact of self-relevance on the recognition of emotional facial expressions while controlling for confounding factors such as familiarity and overlearning. Using a large and diverse sample, we replicated the effect of self-relevance on face processing but found no evidence for a modulation of self-relevance on facial emotion recognition. We propose two potential theoretical explanations to account for these findings and emphasize that further research with different experimental designs and a multitasks measurement approach is needed to understand this mechanism fully. Overall, our study contributes to the literature on the parallel cognitive processing of self-relevance and facial emotion recognition, with implications for both social and cognitive psychology.
Mapping fruit tree dynamics using phenological metrics from optimal Sentinel-2 data and Deep Neural Network
Authors: Chabalala Yingisani , Adam Elhadi , Kganyago Mahlatse 
Published: November 2023

AbstractAccurate and up-to-date crop-type maps are essential for efficient management and well-informed decision-making, allowing accurate planning and execution of agricultural operations in the horticultural sector. The assessment of crop-related traits, such as the spatiotemporal variability of phenology, can improve decision-making. The study aimed to extract phenological information from Sentinel-2 data to identify and distinguish between fruit trees and co-existing land use types on subtropical farms in Levubu, South Africa. However, the heterogeneity and complexity of the study area—composed of smallholder mixed cropping systems with overlapping spectra—constituted an obstacle to the application of optical pixel-based classification using machine learning (ML) classifiers. Given the socio-economic importance of fruit tree crops, the research sought to map the phenological dynamics of these crops using deep neural network (DNN) and optical Sentinel-2 data. The models were optimized to determine the best hyperparameters to achieve the best classification results. The classification results showed the maximum overall accuracies of 86.96%, 88.64%, 86.76%, and 87.25% for the April, May, June, and July images, respectively. The results demonstrate the potential of temporal phenological optical-based data in mapping fruit tree crops under different management systems. The availability of remotely sensed data with high spatial and spectral resolutions makes it possible to use deep learning models to support decision-making in agriculture. This creates new possibilities for deep learning to revolutionize and facilitate innovation within smart horticulture.
Evaluating the effectiveness of the MicroPlastic Sediment Separator (MPSS)
Authors: Prume Julia A. , Laermanns Hannes , Löder Martin G. J. , Laforsch Christian , Bogner Christina , Koch Martin 
Published: November 2023

AbstractEffective laboratory methods are a requirement to obtain accurate data on the contamination of the environment with microplastics. However, current methods often lack specification and validation of performance. The aim of this work was to provide the first evaluation of the effectiveness of the commercially available MicroPlastic Sediment Separator (MPSS) operated with sodium chloride. We performed density separation experiments with pristine plastic particles spiked into both commercial sand (experiment I) and natural river sediments (experiment II) and with environmental microplastics contained in natural river sediments (experiment III). The natural sediments were taken from the Lahn River in Germany, a medium-scale central European tributary. The pristine test particles were ground polypropylene fragments, sieved in three different size classes: larger than 1 mm, 0.5–1 mm, and 0.3–0.5 mm. In experiment I, the mean recovery rate was 97 % for particles of the largest size class (standard deviation $$s=6~\%$$

s
=
6

%

; $$n=30$$

n
=
30

per size class), but dropped to 75.33 % ($$s=21.29~\%$$

s
=
21.29

%

) in the medium and to 54 % ($$s=25~\%$$

s
=
25

%

) in the smallest size class. After density separation, 87 % of all unsuccessfully separated test particles were found at the inner walls of the MPSS. In experiment II, the recovery rate was not correlated with the particle size distribution of the natural river sediments. In experiment III, a subsequent second density separation step contributed on average 38 % ($$s=18~\%$$

s
=
18

%

; $$n=5$$

n
=
5

) to the total number of extracted environmental microplastics. This study illuminates central aspects of a density separation and aims to contribute to quality improvements of recovery rate experiments and field studies for the generation of reliable data on microplastics in the environment.
Fluctuation relations at large scales in three-dimensional hydrodynamic turbulence
Authors: Alexakis Alexandros , Chibbaro Sergio , Michel Guillaume 
Published: November 2023

Abstract
It has long been conjectured that, in three-dimensional turbulence, velocity modes at scales larger than the forcing scale follow equilibrium dynamics. Recent numerical and experimental evidence shows that such modes share the same mean energy and therefore support this claim, but equilibrium dynamics does not reduce to equipartition of energy. In this work, a large set of direct numerical simulations is carried out to investigate if fluctuation-dissipation relations and the fluctuation theorem also apply at these scales. These two results link out-of-equilibrium properties of a forced system with its behavior at equilibrium. Both relations are verified quantitatively by the results of our simulations, further supporting that large-scale modes display equilibrium dynamics. They provide new tools to characterize both the mean value and the fluctuations of the injected energy by a large-scale force acting on turbulence driven by small scale random noise.