bluuebunny/crossref_metadata_2025_split huggingface dataset:
Synthesis of New Indole‐Based Thiazole Derivatives as Potential Antiglycation and Antiα‐Glucosidase Agents: In Vitro and In Silico Studies
Authors: Ullah Asad , Aleem Umair , Shaheen Siddiqui Bina , Haider Sajjad , Khan Majid , Anjum Sajjad , Jahan Humera , Rigano Daniela , Choudhary M. Iqbal , Atta‐ur‐Rahman  , Ul‐Haq Zaheer , Begum Sabira 
Published: December 2023

AbstractDiabetes mellitus is a metabolic disease, characterized by the elevated levels of blood glucose, known as hyperglycemia. It is one of the serious health challenges, and is rapidly becoming a significant cause of morbidity, and mortality, worldwide. The persistent hyperglycemic state in diabetes mellitus leads to the formation of advanced glycation end products (AGEs), which is identified as a key factor involved in the progression of diabetes, and diabetes‐associated late complications. keeping in view the medicinal properties of indole, and thiazole, in the present study, novel indole‐based thiazoles (1–26) were synthesized, and evaluated for theirin vitro α‐glucosidase, and antiglycation activities. These indole‐based thiazoles were characterized from their spectral data. All these compounds showed moderate to excellent antiglycation activity (IC50between 642.2±0.013 to 46.93±0.003 μM) including compounds17,20,22–26which showed a significant antiglycation activity as the reference molecule, rutin (IC50=56±0.008 μM) used as standard. Further, these derivatives exhibited significantα‐glucosidase inhibition activity (P<0.001) with IC50in the range of 111.8±0.9001 and 666.5±1.0111 μM (standard drug acarbose: IC50=855.8±1.2001 μM). Binding interactions of these compounds withα‐glucosidase enzyme were studiedin silico, which showed strong correlation with the experimental data. Inhibition ofα‐glucosidase enzyme, and AGEs formation by these compounds suggest them as promising scaffolds for further studies.
Eu3+ and Tb3+ Coordination Compounds with π‐conjugated Ligands: Luminescence and Structural Properties
Authors: Moraes Fernandes Nathália Maria , Barbosa‐Reis Gustavo , Oliveira‐Silva Diogo , Bagatin Izilda A. 
Published: December 2023

AbstractNew lanthanide‐based luminescent coordination compounds containing quinoline derivatives and 2‐(4‐hydroxyazobenzene)benzoic acid (HABA) were synthesized. Fourier transform infrared spectroscopy (FTIR), UV‐Vis spectra, Elemental analyses, Energy dispersive X‐ray fluorescence (EDXRF), and mass spectrometry (MALDI) were applied for six complexes′ structural elucidation. In addition, photoluminescence spectroscopy was performed in the solid state. Eu3+ and Tb3+ compounds linked to the π‐conjugated system described energy transfer to the metal through the antenna effect. Emission spectra depicted bands at 616–617 nm, characteristics of red light for Europium complexes, assigned as hypersensitive 5D0→7F2 transition, and depicted bands at 540–542 nm (green light) for Terbium complexes, assigned as 5D4→7F5 transition.
A Network Pharmacology Study of the Active Components of Fufang Huangbai Ye for the Treatment of Ulcerative Colitis
Authors: Ke Jianlin , Yang Jingjing , Jiang Xueliang , Wang Lei 
Published: December 2023

AbstractComputational study of the chemical constituents of the traditional Chinese medicinal plant HuangBai against therapeutic targets of ulcerative colitis by using network pharmacology with intent to identify potential candidates to develop novel therapy. Biomolecular proteins like IL1, IL6, JAK2, TNFα, TNFR1, etc. are found to be actively involved in the pathophysiological progression of ulcerative colitis. One of the most popular traditional Chinese medicinal plants, HuangBai, has been used since traditional times for the treatment of colon‐related issues, including inflammatory bowel disease. Thus, in the current research, an attempt has been made to identify the most potent chemical constituent of the concerned plant having therapeutic potential for the treatment of ulcerative colitis. Docking based screening of the prepared ligand library from the chemical constituent of the HuangBai plant against the therapeutic targets involved in the inflammatory reactions associated with ulcerative colitis. Docking results were further confirmed by performing in‐vitro cell line studies. Amurensin and melianone are found to be potent leads targeting inflammatory targets involved in the progression of ulcerative colitis and other inflammatory bowel diseases. Thus, it has been concluded that amurensin and melianone can be used for the development of novel therapeutics to benefit patients with ulcerative colitis.
Cisplatin Destabilizes RNA : DNA Hybrid Structures and Inhibits RNA Function in a CRISPR Model System
Authors: Jain Swapan S. , Ratnikov Danil , Omi Fuadur , Al‐Rubaiye Humam , Fallah Adam , Saccomanno Sage 
Published: December 2023

AbstractRNA has received enormous attention as a biomolecule in the fields of medicine, public health, and biotechnology. Over the last decade, various types of RNA molecules have been exploited as valuable drug targets by different classes of pharmaceutical agents in combating infections and diseases. In this work, we have investigated the binding of Cisplatin to RNA within double stranded RNA : DNA hybrid structures. UV melting and Isothermal Titration Calorimetry studies reveal that Cisplatin binding leads to destabilization of hybrid duplex likely due to Cisplatin‐RNA adduct formation. Gel electrophoretic analysis using an in vitro CRISPR‐Cas9 model system shows that Cisplatin binding to guide RNA leads to a concentration‐dependent reduction in target DNA cleavage.
A Photoelectromagnetic 3D Metal‐Organic Framework from Flexible Tetraarylethylene‐Backboned Ligand and Dynamic Copper‐Based Coordination Chemistry
Authors: Liu Haohao , Wang Shuodong , Huang Mengfan , Bian Qilong , Zhang Yang , Yang Kun , Li Bo , Yao Wenhuan , Zhou Yizhao , Xie Sheng , Tang Ben Zhong , Zeng Zebing 
Published: December 2023

AbstractPorous frameworks that display dynamic responsiveness are of interest in the fields of smart materials, information technology, etc. In this work, a novel copper‐based dynamic metal‐organic framework [Cu3TTBPE6(H2O)2] (H4TTBPE = 1,1,2,2‐tetrakis(4″‐(1H‐tetrazol‐5‐yl)‐[1,1″‐biphenyl]‐4‐yl)ethane), denoted as HNU‐1, is reported which exhibits modulable photoelectromagnetic properties. Due to the synergetic effect of flexible tetraarylethylene‐backboned ligands and diverse copper‐tetrazole coordination chemistries, a complex 3D tunneling network is established in this MOF by the layer‐by‐layer staggered assembly of triplicate monolayers, showing a porosity of 59%. These features further make it possible to achieve dynamic transitions, in which the aggregate‐state MOF can be transferred to different structural states by changing the chemical environment or upon heating while displaying sensitive responsiveness in terms of light absorption, photoluminescence, and magnetic properties.
Fabrication, Evaluation, and Multiscale Simulation of Piezoelectric Composites Reinforced Using Unidirectional Carbon Fibers for Flexible Motion Sensors
Authors: Yu Yaonan , Luo Chao , Suto Takayuki , Uetsuji Yasutomo , Narita Fumio 
Published: December 2023

AbstractPiezoelectric composite materials can convert mechanical energy into electrical energy, thus promoting battery‐free motion‐sensing systems. However, their substandard mechanical performance limits the capability of sensors developed using flexible piezoelectric materials. This study introduces a novel design strategy for preparing high‐strength flexible piezoelectric composite materials comprising unidirectional carbon fiber–reinforced potassium sodium niobate (K0.5Na0.5NbO3) nanoparticle–filled epoxy resin (UDCF/KNN–EP). The fibers significantly improve the Young's modulus of UDCF/KNN–EP along the fiber direction, which reaches 282.5 MPa. Moreover, the composite exhibits excellent stretchability and piezoelectric response () in the cross‐fiber direction under cyclic tensile loading. Multiscale finite element analysis is performed via simulation, which allows theoretical examination of the experimental results and the material's mechanical response mechanism. Finally, UDCF/KNN–EP is seamlessly incorporated into athletic gear and used to measure the impact caused by baseball catching and track footfall patterns. This study harnesses the superior strength of carbon fibers to enhance the durability and dependability of self‐powered sensors without compromising flexibility in specific directions.
Silicon Nanowire Array Weaved by Carbon Chains for Stretchable Lithium‐Ion Battery Anode
Authors: Su Pengfei , Zhang Ziqi , Luo Linshan , Zhang Zhiyong , Lan Chaofei , Li Yahui , Xu Shaowen , Han Xiang , Lin Guangyang , Li Cheng , Huang Wei , Chen Songyan 
Published: December 2023

AbstractTo manufacture flexible batteries, it can be a challenge for silicon base anode materials to maintain structural integrity and electrical connectivity under bending and torsion conditions. In this work, 1D silicon nanowire array structures combined with flexible carbon chains consisting of short carbon nanofibers (CNFs) and long carbon nanotubes (CNTs) are proposed. The CNFs and CNTs serve as chain joints and separate chain units, respectively, weaving the well‐ordered Si nanowire array into a robust and integrated configuration. The prepared flexible and stretchable silicon array anode exhibits excellent electrochemical performance during dynamic operation. A high initial specific capacity of 2856 mAh g−1 is achieved. After 1000 cycles, a capacity retention of 60% (1602 mAh g−1) is maintained. Additionally, the capacity attenuation is less than 1% after 100 bending cycles. This excellent cycling stability is obtained with a high Si loading of 6.92 mg cm−2. This novel approach offers great promise for the development of high‐loading flexible energy‐storage devices.
Smart Enzyme‐Like Polyphenol‐Copper Spray for Enhanced Bacteria‐Infected Diabetic Wound Healing
Authors: Shao Nannan , Huang Siyan , Huang Yueyue , Pan Mengmeng , Xie Yuyu , Chen Qizhu , Chen Chunxiu , Pan Jingye , Zhou Yunlong 
Published: December 2023

AbstractDeveloping functional medical materials is urgent to treat diabetic wounds with a high risk of bacterial infections, high glucose levels and oxidative stress. Here, a smart copper‐based nanocomposite acidic spray has been specifically designed to address this challenge. This copper‐based nanocomposite is pH‐responsive and has multienzyme‐like properties. It enables the spray to effectively eliminate bacteria and alleviate tissue oxidative pressure, thereby accelerating the healing of infected diabetic wounds. The spray works by generating hydroxyl radicals through catalysing H2O2, which has a high sterilization efficiency of 97.1%. As alkaline micro‐vessel leakage neutralizes the acidic spray, this copper‐based nanocomposite modifies its enzyme‐like activity to eliminate radicals. This reduces the level of reactive oxygen species in diabetic wounds by 45.3%, leading to a similar wound‐healing effect between M1 diabetic mice and non‐diabetic ones by day 8. This smart nanocomposite spray provides a responsive and regulated microenvironment for treating infected diabetic wounds. It also offers a convenient and novel approach to address the challenges associated with diabetic wound healing.
Gap State‐Modulated Van Der Waals Short‐Term Memory with Broad Band Negative Photoconductance
Authors: Xu Boyu , Guo Dan , Dong Weikang , Gao Huiying , Zhu Peng , Wang Zhiwei , Watanabe Kenji , Taniguchi Takashi , Luo Zhaochu , Zheng Fawei , Zheng Shoujun , Zhou Jiadong 
Published: December 2023

AbstractFloating gate memory (FGM), composed of van der Waals (vdW) junctions with an atomically thin floating layer for charge storage, is widely employed to develop logic‐in memories and in‐sensor computing devices. Most research efforts of FGM are spent on achieving long‐term charge storage and fast reading/writing for flash and random‐access memory. However, dynamic modulation of memory time via a tunneling barrier and vdW interfaces, which is critical for synaptic computing and machine vision, is still lacking. Here, a van der Waals short‐term memory with tunable memory windows and retention times from milliseconds to thousands of seconds is reported, which is approximately exponentially proportional to the thickness h‐BN (hexagonal boron nitride) barrier. The specific h‐BN barrier with fruitful gap states provides charge release channels for trapped charges, making the vdW device switchable between positive photoconductance and negative photoconductance with a broadband light from IR to UV range. The dynamic short‐term memory with tunable photo response highlights the design strategy of novel vdW memory vis interface engineering for further intelligent information storage and optoelectronic detection.
Research Progress of Prussian Blue and Its Analogs as High‐Performance Cathode Nanomaterials for Sodium‐Ion Batteries
Authors: Yuan Tiefeng , Chen Ya , Gao Xin , Xu Runjing , Zhang Zhiyuan , Chen Xiaodong , Cui Lifeng 
Published: December 2023

AbstractSodium‐ion batteries (SIBs) are investigated as promising alternatives to lithium‐ion batteries (LIBs) on account of the economical abundance and reliable availability of sodium, as well as its analogous chemical properties compared to lithium. Nevertheless, the performance of SIBs is severely restricted by the availability of satisfactory cathode nanomaterials with stable frameworks to accommodate the transportation of large‐sized Na+ ions. These challenges can be effectively resolved when exploiting Prussian blue (PB) and its analogs (PBAs) as SIB cathodes. This is mainly because PB and PBAs have 3D open frameworks with large interstitial space, which are more favorable for fast insertion/extraction of Na+ ions during the charging/discharging process, thus enabling the improvement of integrated performance in SIB systems. This overview offers a comprehensive summarization of recent advancements in the electrochemical performance of PB and PBAs when employing them as cathodes in SIBs. For better understanding, the fabrication strategy, structural characterization, and electrochemical performance exposition are systematically organized and explained according to tuning PB and metal‐based PBAs. Additionally, the current trajectories and prospective future directions pertaining to the utilization of PB and PBA cathodes in the SIB system are thoroughly examined and deliberated upon.
The progress, challenges, and perspectives of directed greybox fuzzing
Authors: Wang Pengfei , Zhou Xu , Yue Tai , Lin Peihong , Liu Yingying , Lu Kai 
Published: December 2023

SummaryGreybox fuzzing is a scalable and practical approach for software testing. Most greybox fuzzing tools are coverage‐guided as reaching high code coverage is more likely to find bugs. However, since most covered codes may not contain bugs, blindly extending code coverage is less efficient, especially for corner cases. Unlike coverage‐guided greybox fuzzing which increases code coverage in an undirected manner, directed greybox fuzzing (DGF) spends most of its time allocation on reaching specific targets (e.g. the bug‐prone zone) without wasting resources stressing unrelated parts. Thus, DGF is particularly suitable for scenarios such as patch testing, bug reproduction, and special bug detection. For now, DGF has become an active research area. However, DGF has general limitations and challenges that are worth further studying. Based on the investigation of 42 state‐of‐the‐art fuzzers that are closely related to DGF, we conducted the first in‐depth study to summarize the empirical evidence on the research progress of DGF. This paper studies DGF from a broader view, which takes into account not only the location‐directed type that targets specific code parts but also the behavior‐directed type that aims to expose abnormal program behaviors. By analyzing the benefits and limitations of DGF research, we try to identify gaps in current research, meanwhile, reveal new research opportunities and suggest areas for further investigation.
Gallic acid attenuates metastatic potential of human colorectal cancer cells through the miR‐1247‐3p‐modulated integrin/FAK axis
Authors: Huang Chi‐Chou , Tsai Ming‐Chang , Wu Yi‐Liang , Lee Yi‐Ju , Yen An‐Ting , Wang Chau‐Jong , Kao Shao‐Hsuan 
Published: December 2023

AbstractColorectal cancer (CRC) exhibits highly metastatic potential even in the early stages of tumor progression. Gallic acid (GA), a common phenolic compound in plants, is known to possess potent antioxidant and anticancer activities, thereby inducing cell death or cell cycle arrest. However, whether GA reduces the invasiveness of CRC cells without inducing cell death remains unclear. Herein, we aimed to investigate the antimetastatic activity of low‐dose GA on CRC cells and determine its underlying mechanism. Cell viability and tumorigenicity were analyzed by MTS, cell adhesion, and colony formation assay. Invasiveness was demonstrated using migration and invasion assays. Changes in protein phosphorylation and expression were assessed by Western blot. The involvement of microRNAs was validated by microarray analysis and anti‐miR antagonist. Our findings showed that lower dose of GA (≤100 μM) did not affect cell viability but reduced the capabilities of colony formation, cell adhesion, and invasiveness in CRC cells. Cellularly, GA downregulated the cellular level of integrin αV/β3, talin‐1, and tensin and diminished the phosphorylated FAK, paxillin, Src, and AKT in DLD‐1 cells. Microarray results revealed that GA increased miR‐1247‐3p expression, and pretreatment of anti‐miR antagonist against miR‐1247‐3p restored the GA‐reduced integrin αV/β3 and the GA‐inhibited paxillin activation in DLD‐1 cells. Consistently, the in vivo xenograft model showed that GA administration inhibited tumor growth and liver metastasis derived from DLD‐1 cells. Collectively, our findings indicated that GA inhibited the metastatic capabilities of CRC cells, which may result from the suppression of integrin/FAK axis mediated by miR1247‐3p.
Diet of the North American river otter (Lontra canadensis) in North Carolina using 2 methods
Authors: Sanders Charles W. , Spear Stephen F. , Black Kristina , Olfenbuttel Colleen , DePerno Christopher S. 
Published: December 2023

AbstractRiver otters (Lontra canadensis) are key predators in North Carolina's aquatic systems, but they are often seen as competitors by anglers and fish hatcheries. River otter diets typically consist of fish and crayfish, but also include occasional herpetofauna, mammals, and birds. While standard diet studies focus on identification of prey through manual examination of stomach contents and feces, metabarcoding DNA analysis has become more popular to determine the presence or frequency of species that are often missed, misidentified, or underestimated. We collected river otter carcasses from licensed trappers and fur dealers across North Carolina from the 2009–10 trapping season through the 2015–16 season. We conducted necropsies and analyzed the stomach contents using standard observational methods and metabarcoding DNA analysis. We manually examined 522 river otter stomachs, of which 377 contained prey items. Decapods (crustaceans) were identified in 41% of stomachs and made up similar percentages within each Furbearer Management Unit (FMU). The order Perciformes composed the majority (62%) of fish prey across all stomach samples. Coastal Plain river otters primarily consumed crustaceans (50%) and fish (40%). Piedmont and Mountain river otters consumed fish (32% and 42%, respectively) most often followed by crustaceans (62% and 50%, respectively). Prey selection was similar between the sexes. Out of 368 samples, metabarcoding DNA examination was able to reliably match 164 prey items to species, 5 classes, 18 orders, 25 families, and 42 genera. Fishes made up 33% of the identifications, particularly Perciformes (13%), Cypriniformes (7%), and Siluriformes (5%). Twelve percent of identifications was made up by Amphibia, split evenly by Anura and Urodela. No birds or reptiles were detected in the Mountain or Piedmont FMUs, and no mammals were detected in the Coastal Plain or Mountain FMU. Overall, river otters in North Carolina consume a large variety of prey that varied regionally. The manual examination provided identifications that were not provided by the DNA examination (i.e., crayfish, brown snakes), while the DNA examination provided a more accurate identification of the broad array of prey items. To understand the composition of annual river otter diets we encourage managers to expand research to evaluate river otter diets year‐round and incorporate additional noninvasive methods (e.g., scat surveys) throughout the year.
Introduction: The Posthumanist Epistemology of Practice Theory
Authors: Cozza Michela , Gherardi Silvia 
Published: December 2023

AbstractThis chapter provides an overview of the book while introducing the main concepts of a posthumanist epistemology of practice theory. In particular, the Introduction articulates the framework of the entire book which is aimed at raising a series of radical epistemological questions about what research practices entail, how such practices—in their variety—generate knowledge, and what are the ethico-onto-epistemological implications of decentering the human beings as the main actors of the research agencement.
Knowing-in-Practice, Its Traces and Ingredients
Authors: Huvila Isto , Sköld Olle , Andersson Lisa 
Published: December 2023

AbstractThis chapter inquires into how two specific types of epistemic artefacts—traces and ingredients—work together and against each other in conveying understanding of past knowledge-making activities. The discussion draws from an analysis of Swedish and French archaeological investigation reports and from how they, as traces and ingredients, contribute to knowing-in-practice in multiple parallel ways as a part of archaeological practice—literally in practice. Traces and ingredients have different epistemic opportunities and limitations to act as records of the past and goads to action even if many traces can act as ingredients and vice versa albeit with certain limitations that are useful to be aware of. Being aware of how an epistemic artefact works in an epistemic sense—for example as a trace or an ingredient—can help to use them accordingly to what they are capable of, to avoid uses that go against their potential, and to develop better ones.
Dancing Urban Waters. A Posthuman Feminist Perspective on Arts-Based Practice for Sustainable Education
Authors: Bruzzone Silvia , Stridsberg Henny 
Published: December 2023

AbstractThe chapter explores how arts-based practices informed by posthuman feminism can contribute to expanding ways of learning and knowing about sustainability. Posthuman feminism relocates agency from the human subject to heterogenous assemblages of humans and nonhumans and anchors subjectivity to the body and materiality. From a pedagogical perspective, this means subverting the traditional approaches rooted in the reproduction of a given area of knowledge and taking all materialities, including the body, into account in the learning process as a way of becoming with the world. The authors set up a workshop in which they mobilise creative dance in order to explore different approaches to urban water, in particular flooding, with students of industrial engineering. The students explore the materialities involved in urban flooding through corporeal interactions and creative tasks. They physically experience becoming bodies of water, encountering and intra-acting with “hard”, protective infrastructures as well as more sustainable solutions under the new paradigm “more room for water”. Through these bodily practices, the students multiply the ways of experiencing connectedness with urban water beyond control and mastery as part of a watery subjectivity. The experiment and methodology also contribute to the conversation on post-qualitative research in the framework of a posthumanist epistemology of practice.