bluuebunny/crossref_metadata_2025_split huggingface dataset:
Injection of Freshly Collected Adipose Tissue for the Treatment Complex Cryptoglandular Anal Fistula: Case Report
Authors: Londoño Estrada Daniel Mauricio , Fernandes Cristiane Koizimi Martos , Oliveira Marina Barbarela Grisolia de , Souza Gustavo Moreira Costa de , Rocha França-Neto Paulo , Lopes de Queiroz Fábio , Lacerda-Filho Antônio 
Published: October 2023

AbstractIntroduction Perianal fistula is a common colorectal disease which is caused mainly by cryptoglandular disease. Although most cases are treated successfully by surgery, management of complex perianal fistulas (CPAF) remains a challenge with limited results in recurrence and sometimes associated with fecal incontinence. The CPAF treatment with autologous adipose-derived mesenchymal stem cells (ASCs) had become a research hotspot. The technique started to be used in the treatment of Crohn's disease (CD) fistulas, where the studies showed safe and goods result from the procedure. Cultured ASCs have been used but this approach requires the preceding collection of adipose tissue, time for isolation of ASCs and subsequent in vitro expansion, need for laboratory facilities, and expertise in cell culturing. These factors have been getting over by using the commercially available alternative, allogenic ASCs. Treatment with allogeneic ASCs has shown good results in patients with CD fistulas, however with the disadvantage of being expensive. Objective To show that the injection with freshly collected adipose tissue is an alternative to treatment with autologous or allogenic ASCs with several advantages. Methods: In this case report, we show our first experience in the treatment of CPAF with the application of collected adipose tissue in a tertiary referral hospital from Belo Horizonte, Brazil. Results The patient had a good postoperative recuperation with a complete fistula healing after 8 months without adverse effects. Conclusion Injection with freshly collected adipose tissue is a promising and apparently safe sphincter-sparing technique in the treatment of CPAF.
Legal labelling regime and its relevance on the translation of wine
labels (EN-ES-FR)
Authors: Ponce Gisella Policastro 
Published: October 2023

Abstract
Every translation requires a prior process that facilitates the
translation work and contributes to its correct execution at all levels.
Label translation requires a very particular and characteristic process in
which regulations play a very important role. In particular, wine labels
have gained more visibility due to consumer demands and market conditions.
Closely tied with this is the remarkable growth the wine sector experienced
in the recent years, in particular within the EU wine market. There has been
a large interest in the vitiviniculture industry, and the marketing of such
products has therefore increased. This in turn makes it necessary to draw up
which are the regulatory obligations we have to comply with when exporting a
wine product which is totally linked to labelling and its translation
process.
Non-expert wine discourse interpretation
Authors: Merino Ferradá María del Carmen 
Published: October 2023

Abstract
Analyses of how wine experts use language to describe wine
experience abound in academic works from different perspectives. However,
little attention has been devoted to understanding the processes underlying
wine discourse interpretation by general consumers, a large segment of the
wine community that often lacks essential specific lexical and conceptual
knowledge of the field. In this paper a proposal is built about how
non-expert wine discourse interpretation develops. Based on Relevance theory
together with a close analysis non-expert preferences and the specific
design of the linguistic stimuli, we construct a hypothesis about the
inferential nature of wine discourse interpretation and the lines along
which this process could develop.
Sipping or glugging
Authors: Gallardo Carmen Noya , Calderón-López María Isabel 
Published: October 2023

Abstract
Wine culture has increasingly become part of our lives. The
knowledge of the specific wine tasting terms is a major concern especially
for non-professionals and for non-expert consumers. One of the main
characteristics of this terminology is that it is constantly evolving and as
a result it affects wine descriptors. Our objective is to describe the main
characteristics of the processes and reasons for creating non-conventional
wine tasting terms from two different approaches, semantic and rhetorical.
Communicating our personal, subjective and pleasing experience and emotions,
and expressing them by means of familiar, ordinary and everyday life words,
which are considered to be unconventional in this field, is a recurrent
procedure as opposed to the use of conventional terms.
From wine description to wine formalization
Authors: Zarco-Tejada Mª Ángeles 
Published: October 2023

Abstract
In this paper we address the problem of formalizing content of
the wine domain within a more general ontological context and concentrate on
the adjective-noun constructions. For our research we have selected data
from the web and have faced the recent evaluative adjectives introduced to
describe wine these days. We show how some language uses convey aspects of
meaning that should be coded as part of the lexical semantics of the noun
“wine”, since understanding some metaphors is only possible if some
conventional activities related to wine are considered. For this purpose, we
have chosen Pustejovsky’s Qualia Structures and have suggested
Conventionalized Attributes (CA) as a means to represent hidden meanings
that are the bases for the correct interpretation of new metaphorical
uses.
Far-field pattern control and light-extraction enhancement of deep-ultraviolet light-emitting diodes with large-area Fresnel zone plate nano-structures
Authors: Wei Lingjie , Taniguchi Manabu , Hao Guo-Dong , Inoue Shin-ichiro 
Published: October 2023

Abstract
Conventional methods using high-purity quartz lenses to control deep-ultraviolet light-emitting diode (DUV-LED) far-field patterns have limitations, including small effective apertures and high cost. We apply phase-type Fresnel zone plates to control the beam angle and enhance light extraction efficiency (LEE) for DUV-LEDs on sapphire and AlN substrates. We demonstrate highly-collimated optics-free DUV-LED emissions with full width at half maximum far-field divergence angles of 40° and 10° on sapphire and AlN substrates at a peak emission wavelength of 279 nm and 273 nm, respectively. LEE enhancements of 1.4 and 1.5 times for DUV-LEDs on sapphire and AlN substrates, respectively, are also achieved.
Remaining useful life prediction of ball screw based on integrating preload and precision
Authors: Zhang Yishen , Zhou Changguang , Nie Conghui , Feng Hutian 
Published: October 2023

Abstract
Ball screw remaining useful life (RUL) prediction is of great interest to industry and academia. However, the lack of a reliable prediction model limits accuracy. To address this, a hybrid method that combines physical-based and data-driven methods is proposed. A novel integrated index is developed to capture wear degradation by integrating the preload and precision parameters, and the optimum partitioning method is used for wear stage categorization. A physical-based method of a two-stage empirical model is constructed to characterize the randomness and nonlinearity of the degradation process. Model parameters are initialized and updated using particle filtering (PF) through a data-driven method for RUL prediction. To address discontinuous predictions in the empirical model, the random forest with PF (RF-PF) method is employed. The effectiveness of this approach is evaluated through experiments and comparisons with other methods.
A novel roundness error evaluation method for high-speed EMU train axles
Authors: Wang Hao , Liu Changying , Hou Yuguang , Wang Libin , An Bowen , Liu Yang 
Published: October 2023

Abstract
This article proposes a novel roundness error evaluation method for high-speed electric multiple units (EMU) train axles to evaluate the roundness error of the minimum zone circle. This method utilizes the adaptive ability of Bayesian linear regression to the data to solve the initial center of the circle, avoiding the multiple search process, which not only improves the data utilization and simplifies the solving steps but also has a strong noise immunity. The method first establishes a Hough space model, maps the collected data points to the Hough space, and forms different conical surfaces; then, by Bayesian linear regression, the probability density function is set with the distance from the space point to the conical surface as a parameter, and through continuous iteration, the point with the highest probability value is the more accurate initial center of the circle. Finally, the final optimal center of the circle is obtained by the principle of minimum inclusion region. We conducted experimental studies on axles of different diameters and compared them with other methods. The results prove the practicality and effectiveness of the technique.
Highly efficient, self-powered UV photodiodes based on leadfree perovskite nanocrystals through interfacial engineering
Authors: Huang Xiaoyu , Sun Hong-Tao , Shirahata Naoto 
Published: October 2023

Abstract
Double perovskite crystals are promising alternatives for lead-based perovskites that has potential to address toxicity and instability issues. In this study, Cs2AgBiCl6 nanocrystals (NCs) with high absorption coefficients were synthesized by hot-injection method. The bandgap engineering was realized by tuning the halide composition in Cs2AgBiCl6 to Cs2AgBiBr6. Both NCs were used as light-absorbing layers in lead-free perovskite photodiodes that exhibit wavelength-selectivity for UV–visible light operatable even at a bias voltage of 0 V. Cs2AgBiBr6-based photodiode exhibits a characteristic detection peak at 340 nm with a responsivity of 3.21 mA W−1, a specific detectivity up to 8.91 × 1010 Jones and a fast response speed with a rise/fall time of 30/35 ms. The excellent performance of self-driven photodiodes lights up the prospect of lead-free perovskite NCs in highly efficient optoelectronic devices.
Weighing demonstration experiment based on light spot deflection method
Authors: Yang Fan , Cao Yuqing , Li Jiameng , Song Yue , Zhang Kaiyang 
Published: October 2023

Abstract
The cantilever beam is a well-known mechanical model among science and engineering students. In general physics experiments, the light spot deflection method serves as an optical amplification technique for measuring small rotations. In this study, a method for measuring the angular deformation of a cantilever beam using the light spot deflection method is proposed and applied to weight measurement. Furthermore, we replaced the scaleplate in the traditional light spot deflection method with charge-coupled device (CCD). By employing the linear arrangement of CCD pixels and the digital speckle algorithm, the convenience and accuracy of the spot movement measurement have been greatly improved.
Design study of a novel geometrical arrangement for an in-beam small animal positron emission tomography scanner
Authors: Lovatti Giulio , Nitta Munetaka , Javad Safari Mohammad , Gianoli Chiara , Pinto Marco , Dedes Georgios , Zoglauer Andreas , Thirolf Peter G , Parodi Katia 
Published: October 2023

Abstract

Objective. We designed a geometrical solution for a small animal in-beam positron emission tomography (PET) scanner to be used in the project SIRMIO (Small animal proton irradiator for research in molecular image-guided radiation-oncology). The system is based on 56 scintillator blocks of pixelated LYSO crystals. The crystals are arranged providing a pyramidal-step shape to optimize the geometrical coverage in a spherical configuration. Approach. Different arrangements have been simulated and compared in terms of spatial resolution and sensitivity. The chosen setup enables us to reach a good trade-off between a solid angle coverage and sufficient available space for the integration of additional components of the first design prototype of the SIRMIO platform. The possibility of moving the mouse holder inside the PET scanner furthermore allows for achieving the optimum placement of the irradiation area for all the possible tumor positions in the body of the mouse. The work also includes a study of the scintillator material where LYSO and GAGG are compared with a focus on the random coincidence noise due to the natural radioactivity of Lutetium in LYSO, justifying the choice of LYSO for the development of the final system. Main results. The best imaging performance can be achieved with a sub-millimeter spatial resolution and sensitivity of 10% in the center of the scanner, as verified in thorough simulations of point sources. The simulation of realistic irradiation scenarios of proton beams in PMMA targets with/without air gaps indicates the ability of the proposed PET system to detect range shifts down to 0.2 mm. Significance. The presented results support the choice of the identified optimal design for a novel spherical in-beam PET scanner which is currently under commissioning for application to small animal proton and light ion irradiation, and which might find also application, e.g. for biological image-guidance in x-ray irradiation.
A key mutation in magnesium chelatase I subunit leads to a chlorophyll-deficient mutant of tea (Camellia sinensis)
Authors: Zhang Chenyu , Liu Haoran , Wang Junya , Li Yuanyuan , Liu Dingding , Ye Yuanyuan , Huang Rong , Li Sujuan , Chen Liang , Chen Jiedan , Yao Mingzhe , Ma Chunlei 
Published: October 2023

Abstract
Tea (Camellia sinensis) is a highly important beverage crop renowned for its unique flavour and health benefits. Chlorotic mutants of tea, known worldwide for their umami taste and economic value, have gained global popularity. However, the genetic basis of this chlorosis trait remains unclear. In this study, we identified a major-effect quantitative trait locus (QTL), qChl-3, responsible for the chlorosis trait in tea leaves, linked to a non-synonymous polymorphism (G1199A) in the magnesium chelatase I subunit (CsCHLI). Homozygous CsCHLIA plants exhibited an albino phenotype due to defects in magnesium protoporphyrin IX and chlorophylls in the leaves. Biochemical assays revealed that CsCHLI mutations did not affect subcellular localization or interactions with CsCHLIG and CsCHLD. However, combining CsCHLIA with CsCHLIG significantly reduced ATPase activity. RNA-seq analysis tentatively indicated that CsCHLI inhibited photosynthesis and enhanced photoinhibition, which in turn promoted protein degradation and increased the amino acid levels in chlorotic leaves. RT-qPCR and enzyme activity assays confirmed the crucial role of asparagine synthetase and arginase in asparagine and arginine accumulation, with levels increasing over 90-fold in chlorotic leaves. Therefore, this study provides insights into the genetic mechanism underlying tea chlorosis and the relationship between chlorophyll biosynthesis and amino acid metabolism.
Unfriendly partitions when avoiding vertices of finite degree
Authors: Fiorini Aurichi Leandro , Silva Sinzato Real Lucas 
Published: October 2023

Abstract
An unfriendly partition of a graph $G = (V,E)$ is a function $c: V \to 2$ such that $|\{x\in N(v): c(x)\neq c(v)\}|\geq |\{x\in N(v): c(x)=c(v)\}|$ for every vertex $v\in V$, where $N(v)$ denotes its neighborhood. It was conjectured by Cowan and Emerson [2] that every graph has an unfriendly partition, but Milner and Shelah in [5] found counterexamples for that statement by analysing graphs with uncountably many vertices. Curiously, none of their graphs have vertices with finite degree. Therefore, as a natural direction to approach, in this paper we search for the least cardinality of a graph with this property and that admits no unfriendly partitions. Actually, among some other independence results, we conclude that this value cannot be precisely determined within $\textrm {ZFC}$, in the sense that it may vary from model to model of set theory.
Trends in prevalence, treatment use, and disease burden in patients with eosinophilic granulomatosis with polyangiitis in Japan: Real-world database analysis
Authors: Sada Ken-ei , Suzuki Takeo , Joksaite Sandra , Ju Shinyoung , Logie John , Mu George , Hwee Jeremiah , Kunishige Hideaki , Ishii Takeo , Adlak Amit , Vadlamudi Harini , Alfonso-Cristancho Rafael 
Published: October 2023

ABSTRACT

Objectives
We report the prevalence of eosinophilic granulomatosis with polyangiitis (EGPA) and describe oral corticosteroid (OCS) use and disease burden before and after the mepolizumab approval in 2018 for EGPA in Japan.

Methods
Two retrospective studies (GSK IDs: 218083 and 218084) used two databases: (1) the JMDC insurer database (Japanese health insurer claims) was used to report annual EGPA prevalence and OCS use in mepolizumab-treated patients and (2) Medical Data Vision database was used to report annual treatment use, OCS dose, relapses, and healthcare resource utilization in patients with EGPA.

Results
EGPA prevalence (95% confidence interval) increased from 4.2 (0.1, 23.4) in 2005 to 58.6 (53.2, 64.5) per 1,000,000 in 2020. Median OCS dose (mg/day) decreased from a range of 4.8–7.7 during 2010–2017 to 4.5–4.8 during 2018–2020 (lowest dose in 2020). The proportion of patients with prednisolone-equivalent daily OCS dose &gt;10 mg decreased from 2017 (11.9%) to 2020 (10.3%), while the median dose halved. The proportion of patients with EGPA relapses (64.3% to 41.6%) and hospitalization (27.8% to 23.6%) decreased from 2010 to 2020.

Conclusions
EGPA prevalence increased between 2005 and 2020. With the introduction of mepolizumab for EGPA in 2018, real-world OCS use, relapses, and healthcare resource utilization decreased.
DisProt in 2024: improving function annotation of intrinsically disordered proteins
Authors: Aspromonte Maria Cristina , Nugnes Maria Victoria , Quaglia Federica , Bouharoua Adel ,   DisProt Consortium, Sagris Vasileios , Promponas Vasilis J , Chasapi Anastasia , Fichó Erzsébet , Balatti Galo E , Parisi Gustavo , Buitrón Martín González , Erdos Gabor , Pajkos Matyas , Dosztányi Zsuzsanna , Dobson Laszlo , Conte Alessio Del , Clementel Damiano , Salladini Edoardo , Leonardi Emanuela , Kordevani Fatemeh , Ghafouri Hamidreza , Ku Luiggi G Tenorio , Monzon Alexander Miguel , Ferrari Carlo , Kálmán Zsófia , Nilsson Juliet F , Santos Jaime , Pintado-Grima Carlos , Ventura Salvador , Ács Veronika , Pancsa Rita , Kulik Mariane Goncalves , Andrade-Navarro Miguel A , Pereira Pedro José Barbosa , Longhi Sonia , Mercier Philippe Le , Bergier Julian , Tompa Peter , Lazar Tamas , Tosatto Silvio C E , Piovesan Damiano 
Published: October 2023

Abstract
DisProt (URL: https://disprot.org) is the gold standard database for intrinsically disordered proteins and regions, providing valuable information about their functions. The latest version of DisProt brings significant advancements, including a broader representation of functions and an enhanced curation process. These improvements aim to increase both the quality of annotations and their coverage at the sequence level. Higher coverage has been achieved by adopting additional evidence codes. Quality of annotations has been improved by systematically applying Minimum Information About Disorder Experiments (MIADE) principles and reporting all the details of the experimental setup that could potentially influence the structural state of a protein. The DisProt database now includes new thematic datasets and has expanded the adoption of Gene Ontology terms, resulting in an extensive functional repertoire which is automatically propagated to UniProtKB. Finally, we show that DisProt's curated annotations strongly correlate with disorder predictions inferred from AlphaFold2 pLDDT (predicted Local Distance Difference Test) confidence scores. This comparison highlights the utility of DisProt in explaining apparent uncertainty of certain well-defined predicted structures, which often correspond to folding-upon-binding fragments. Overall, DisProt serves as a comprehensive resource, combining experimental evidence of disorder information to enhance our understanding of intrinsically disordered proteins and their functional implications.
UTexas Aptamer Database: the collection and long-term preservation of aptamer sequence information
Authors: Askari Ali , Kota Sumedha , Ferrell Hailey , Swamy Shriya , Goodman Kayla S , Okoro Christine C , Spruell Crenshaw Isaiah C , Hernandez Daniela K , Oliphant Taylor E , Badrayani Akshata A , Ellington Andrew D , Stovall Gwendolyn M 
Published: October 2023

Abstract
A growing interest in aptamer research, as evidenced by the increase in aptamer publications over the years, has led to calls for a go-to site for aptamer information. A comprehensive, publicly available aptamer dataset, which may be a repository for aptamer data, standardize aptamer reporting, and generate opportunities to expand current research in the field, could meet such a demand. There have been several attempts to create aptamer databases; however, most have been abandoned or removed entirely from public view. Inspired by previous efforts, we have published the UTexas Aptamer Database, https://sites.utexas.edu/aptamerdatabase, which includes a publicly available aptamer dataset and a searchable database containing a subset of all aptamer data collected to date (1990–2022). The dataset contains aptamer sequences, binding and selection information. The information is regularly reviewed internally to ensure accuracy and consistency across all entries. To support the continued curation and review of aptamer sequence information, we have implemented sustaining mechanisms, including researcher training protocols, an aptamer submission form, data stored separately from the database platform, and a growing team of researchers committed to updating the database. Currently, the UTexas Aptamer Database is the largest in terms of the number of aptamer sequences with 1,443 internally reviewed aptamer records.