bluuebunny/crossref_metadata_2025_split huggingface dataset:
The impacts of non-native watercress in Oklahoma spring ecosystems
Authors: Bergey Elizabeth A. 
Published: January 2024

AbstractWatercress (Nasturtium officinale) has spread widely from Europe and commonly occurs in Oklahoma (USA) springs. Watercress is usually an emergent plant and affects water flow patterns and may provide habitat for biota. Although watercress is not considered an invasive species, its impacts in springs have not been reported. With a goal to describe possible impacts of watercress in springs, 14 karst-associated springs (12 with watercress) were surveyed for sediment characteristics, macroinvertebrates, and diatoms in July 2021. The effects of watercress were evident. Sediment particle size was unaffected by the presence of watercress but sediment organic matter was higher under watercress beds than outside of beds. Although there was no difference in total benthic macroinvertebrate density or richness, higher organic matter was associated with slightly higher abundances of detritivorous and predatory macroinvertebrates (SIMPER). Submerged portions of watercress had significantly much lower diatom density than other spring substrates, with diatom composition similar to other plants but different from that of rocks. Self-shading or possible allelopathy may cause the low diatom density. The significantly lower macroinvertebrate density within watercress mats relative to that of other plants may result from a reduced food source because the plant’s low diatom density. Only predatory damselflies were more common in watercress than in other plants, which had more abundant grazers. Although watercress can increase heterogeneity in sediments and is sometimes valued as an edible plant, watercress supports low algal and macroinvertebrate densities, such that extensive growth of watercress can have an overall negative impact on spring ecosystems.
KGTN-ens: few-shot image classification with knowledge graph ensembles
Authors: Filipiak Dominik , Fensel Anna , Filipowska Agata 
Published: January 2024

AbstractWe propose KGTN-ens, a framework extending the recent Knowledge Graph Transfer Network (KGTN) in order to incorporate multiple knowledge graph embeddings at a small cost. There are many real-world scenarios in which the amount of data is severely limited (e.g. health industry, rare anomalies). Prior knowledge can be used to tackle this task. In KGTN, one can use a single knowledge source at once. The purpose of this study is to investigate the possibility of combining multiple knowledge sources. We evaluate it with different embeddings in a few-shot image classification task. Our model is partially trained on $$k \in \{ 1, 2, 5, 10\}$$

k
∈
{
1
,
2
,
5
,
10
}

samples. We also construct a new knowledge source – Wikidata embeddings – and evaluate it with KGTN and KGTN-ens. With ResNet50, our approach outperforms KGTN in terms of the top-5 accuracy on the ImageNet-FS dataset for the majority of tested settings. For $$k \in \{ 1, 2, 5, 10\}$$

k
∈
{
1
,
2
,
5
,
10
}

respectively, we obtained +0.63/+0.58/+0.43/+0.26 pp. (novel classes) and +0.26/+0.25/+0.32/–0.04 pp. (all classes).
circGRHPR inhibits aberrant epithelial-mesenchymal transformation progression of lung epithelial cells associated with idiopathic pulmonary fibrosis
Authors: Wu Wensi , Wang Zhi , Zhang Huiying , Zhang Xiaojun , Tian Hui 
Published: January 2024

AbstractAir pollution has greatly increased the risk of idiopathic pulmonary fibrosis (IPF). Circular RNAs (circRNAs) have been found to play a significant role in the advancement of IPF, but there is limited evidence of correlation between circRNAs and lung epithelial cells (LECs) in IPF. This research aimed to explore the influence of circRNAs on the regulation of EMT progression in LECs, with the objective of elucidating its mechanism and establishing its association with IPF. Our results suggested that the downregulation of circGRHPR in peripheral blood of clinical cases was associated with the diagnosis of IPF. Meanwhile, we found that circGRHPR was downregulated in transforming growth factor-beta1 (TGF-β1)–induced A549 and Beas-2b cells. It is a valid model to study the abnormal EMT progression of IPF-associated LECs in vitro. The overexpression of circGRHPR inhibited the abnormal EMT progression of TGF-β1-induced LECs. Furthermore, as the sponge of miR-665, circGRHPR released the expression of E3 ubiquitin-protein ligase NEDD4-like (NEDD4L), thus promoting its downstream transforming growth factor beta receptor 2 (TGFBR2) ubiquitination. It is helpful to reduce the response of LECs to TGF-β1 signaling. In summary, circGRHPR/miR-665/NEDD4L axis inhibited the abnormal EMT progression of TGF-β1-induced LECs by promoting TGFBR2 ubiquitination, which provides new ideas and potential targets for the treatment of IPF.
Graphical Abstract
Graphical headlights
1. Downregulation of circGRHPR in peripheral blood is associated with clinical diagnosis of IPF.
2. circGRHPR inhibits the abnormal EMT progression of TGF-β1-induced LECs in vitro.
3. circGRHPR/miR-665/NEDD4L axis inhibits the abnormal EMT progression of TGF-β1-induced LECs by promoting ubiquitination of TGFBR2 in vitro.
TFEB and TFE3 cooperate in regulating inorganic arsenic-induced autophagy-lysosome impairment and immuno-dysfunction in primary dendritic cells
Authors: Xu Guowei , Peng Huaguang , Yao Ran , Yang Yuqing , Li Bing 
Published: January 2024

AbstractArsenic (As) is a prevalent and hazardous environmental toxicant associated with cancer and various health problems, which has been shown suppressive effects on dendritic cells (DCs). Autophagy is essential for the innate and adaptive immune responses of DCs, and the transcription factors TFEB and TFE3 are key regulators of autophagic and lysosomal target genes. However, the detrimental alterations of the autophagy-lysosome pathway in As-exposed DCs and the possible coordinating roles of TFEB and TFE3 in the immune dysfunction of this cell are less understood. In this paper, we found that As exposure significantly impaired lysosomal number, lysosomal acidic environment, and lysosomal membrane permeabilization, which might lead to blocked autophagic flux in cultured DCs. Furthermore, our results confirmed that TFEB or TFE3 knockdown exacerbated the disorders of lysosome and the blockade of autophagic flux in As-exposed DCs, and also enhanced the inhibitory expression of co-stimulatory molecules Cd80 and Cd83; adhesion molecule Icam1; cytokines TNF-α, IL-1β, and IL-6; chemokine receptor Ccr7; and antigen-presenting molecules MHC II and MHC I. By contrast, overexpression of TFEB or TFE3 partially alleviated the above-mentioned impairment of DCs by inorganic As exposure. In conclusion, these findings reveal a previously unappreciated inhibition of lysosome-mediated degradation and damage of lysosomal membrane integrity leading to dysregulated autophagy and impaired immune functions of DCs by arsenicals, and also suggest TFEB and TFE3 as potential therapeutic targets for ameliorating As toxicity.
Graphical abstract
POU6F1 promotes ferroptosis by increasing lncRNA-CASC2 transcription to regulate SOCS2/SLC7A11 signaling in gastric cancer
Authors: Wang Jingyun , Jia Qiaoyu , Jiang Shuqin , Lu Wenquan , Ning Hanbing 
Published: January 2024

Abstract
Objective
This study investigated the effect and mechanism of POU6F1 and lncRNA-CASC2 on ferroptosis of gastric cancer (GC) cells.

Methods
GC cells treated with erastin and RSL3 were detected for ferroptosis, reactive oxygen species (ROS) level, and cell viability. The expression levels of POU6F1, lncRNA-CASC2, SOCS2, and ferroptosis-related molecules (GPX4 and SLC7A11) were also measured. The regulations among POU6F1, lncRNA-CASC2, FMR1, SOCS2, and SLC7A11 were determined. Subcutaneous tumor models were established, in which the expressions of Ki-67, SOCS2, and GPX4 were detected by immunohistochemistry.

Results
GC patients with decreased expressions of POU6F1 and lncRNA-CASC2 had lower survival rate. Overexpression of POU6F1 or lncRNA-CASC2 decreased cell proliferation and GSH levels in GC cells, in addition to increasing total iron, Fe2+, MDA, and ROS levels. POU6F1 directly binds to the lncRNA-CASC2 promoter to promote its transcription. LncRNA-CASC2 can target FMR1 and increase SOCS2 mRNA stability to promote SLC7A11 ubiquitination degradation and activate ferroptosis signaling. Knockdown of SOCS2 inhibited the ferroptosis sensitivity of GC cells and reversed the effects of POU6F1 and lncRNA-CASC2 overexpression on ferroptosis in GC cells.

Conclusion
Transcription factor POU6F1 binds directly to the lncRNA-CASC2 promoter to promote its expression, while upregulated lncRNA-CASC2 increases SOCS2 stability and expression by targeting FMR1, thereby inhibiting SLC7A11 signaling to promote ferroptosis in GC cells and inhibit GC progression.
Establishing Quality and Outcome Measures for Recovery Housing: A Tiered Approach Supporting Service Evolution
Authors: Thompson Robin A. , Johnson David , Ashworth Madison , Stott Milena 
Published: January 2024

AbstractWith over one-hundred thousand drug overdose deaths in 2021, substance use disorder (SUD) is a public health crisis in the United States. Medical stabilization has been the predominant focus of SUD interventions despite low levels of retention. Consequently, national quality measures for SUD care outside the clinical continuity of care are limited. The expansion of recovery support services addressing social drivers of health outside clinical settings is needed. The current SUD quality measures are not applicable nor feasible for recovery support service providers with limited resource capacities, like the estimated 17,900 recovery housing providers nationwide. Despite widespread support for recovery housing and its documented effectiveness, no universal set of measures has been developed for widespread adoption. In this brief, a matrix of quality measures are proposed to meet the needs of recovery housing providers with various capacities to support service evolution and improve equitable SUD treatment and recovery care.
RETRACTED ARTICLE: Entrée or Sampler? A Randomized Controlled Trial of Two Approaches to Single Session Internet-Based Interventions
Authors: Bartels Graham C. , Cheavens Jennifer S. , Strunk Daniel R. 
Published: January 2024

Abstract
Background
Interventions teaching cognitive-behavioral skills feature prominently among evidence-based treatments for emotional disorders. However, the relative impact of interventions that teach one cognitive-behavioral skill in-depth (i.e., an entrée intervention) versus those that provide limited coverage of multiple skills (i.e., a sampler intervention) remains unclear. In this study, we compared these two approaches using unguided single-session internet-based cognitive-behavioral interventions.

Methods
A total of 657 participants living in the U.S. with elevated depressive symptoms were randomly assigned to the entrée, sampler, or no-intervention control conditions. The entrée approach focused in-depth on developing one skill and the sampler condition introduced three skills. Both interventions lasted approximately 30 min. All participants completed measures of depressive symptoms, loneliness, and coping skill use and quality before the intervention and a week after the intervention.

Results
There were no condition differences in change in depressive symptoms, coping skill usage, coping skill quality, or loneliness. Those in the sampler condition were less likely to drop out than those in the entrée condition. In addition, condition differences were moderated by initial depressive symptom severity, such that among the more severely depressed the sampler condition led to greater symptom reduction than the entrée and control conditions.

Conclusions
We did not find overall differences between the entrée, sampler, and control conditions on primary outcomes. Nonetheless, the differences that did emerge suggest offering a variety of skills improves retention and provides greater relief for those with high initial depressive symptom severity in single-session internet-based interventions.
Clinicaltrials.gov ID NCT04643964, registered on 11/12/2020.
Compositional non-blockingness verification of finite automata with prioritised events
Authors: Tang Yiheng , Moor Thomas 
Published: January 2024

AbstractThis paper addresses the verification of non-blockingness for modular discrete-event systems, i.e., discrete-event systems that are composed from component models. For such systems, the explicit construction of a monolithic representation turns out intractable for relevant applications, since such a construction in general is of exponential cost w.r.t. the number of components. One well established approach to circumvent the need for a monolithic representation for the verification task at hand is to alternate (a) the substitution of individual components by abstractions and (b) the composition of only a small number of strategically chosen components at a time. When successful, one ends up with a single moderately sized automaton which does not represent the overall behaviour in any detail but which does block if and only if the original modular system fails to be non-conflicting. This approach is referred to as compositional verification and originates from the field of process algebra with more recent adaptations to finite automata models. The main contribution of the present study is the development of a number of abstraction rules valid for compositional verification of non-conflictingness in the presence of global event priorities, i.e., where high priority events from one component possibly preempt events with lower priority of all components.
Factors influencing student teachers’ intention to use mobile augmented reality in primary science teaching
Authors: Nikou Stavros A. 
Published: January 2024

AbstractThanks to the advancement of mobile technologies, Augmented Reality (AR) has become broadly accessible through mobile devices such as smartphones and tablets. Mobile Augmented Reality can benefit science education in a variety of ways. However, except from some sporadic experimental cases, it is rather rarely employed by teachers and has not yet been fully introduced in education. Moreover, little research exists about the adoption behavior of mobile AR by pre-service teachers. Against this background, the current study proposes and validates an integrated adoption model to explain and predict the factors that significantly influence student teachers’ intentions to use mobile AR in teaching primary science. The study also introduces two new constructs, Perceived Immersion and Perceived Educational Value in the context of mobile AR. Eighty-nine undergraduate pre-service primary school teachers participated in a mobile augmented reality workshop creating mobile augmented reality experiences for teaching physics to primary school pupils. Following that, student teachers answered an online survey. The quantitative survey data was analysed using structural equation modelling. The study confirmed the proposed model explaining and predicting approximately 72% of the variance of student teachers’ Behavioral Intention to Use mobile AR to teach primary science. Perceived Immersion and Perceived Educational Value significantly influence Behavioral Intention to Use after being mediated by Perceived Usefulness. The study offers insight into the factors influencing pre-service primary teachers’ intentions to utilise mobile augmented reality (AR) in their future lessons, which is relevant given the growing interest in utilising these technologies in education. Implications are discussed.
Trapped in Place? Ethnic and Educational Heterogeneity in Residential Mobility and Integration of Young Adults in Brussels
Authors: Imeraj Lena , Gadeyne Sylvie 
Published: January 2024

Abstract
Spatial assimilation theory asserts that immigrants’ socioeconomic progress leads to residential adaptation and integration. This association has proven robust in USA and European urban areas through much of the twentieth century, but drastic change of ethnic and class compositions yet persistent (neighbourhood) inequality in the urban landscape urge us to reconsider the dynamic interaction between stability and change. In this study, we investigate to what extent education shapes residential mobility differently for young adults with varying ethnic and social origins. Focussing on Brussels, we use multinomial logistic regressions on linked longitudinal population-based censuses from 1991 and 2001 and register data for the period 2001–2006. Analyses show that dispersal away from poor inner-city neighbourhoods appears least likely for the offspring of poor low-educated non-Western households, regardless of their own educational attainment. While our approach roughly confirms traditional arguments of socio-spatial integration, it also reveals how educational success generates opportunities to escape poor neighbourhoods for some but not for others. With this, it points at the subtle ways in which factors and mechanisms in traditional spatial assimilation theory affect residential behaviour of young adults over their life course, at the intersection of specific locales, ethnic groups, social classes and generations.
Extremes for stationary regularly varying random fields over arbitrary index sets
Authors: Passeggeri Riccardo , Wintenberger Olivier 
Published: January 2024

AbstractWe consider the clustering of extremes for stationary regularly varying random fields over arbitrary growing index sets. We study sufficient assumptions on the index set such that the limit of the point processes of the exceedances above a high threshold exists. Under the so-called anti-clustering condition, the extremal dependence is only local. Thus the index set can have a general form compared to previous literature (Basrak and Planinić in Bernoulli 27(2):1371–1408, 2021; Stehr and Rønn-Nielsen in Extremes 24(4):753–795, 2021). However, we cannot describe the clustering of extreme values in terms of the usual spectral tail measure (Wu and Samorodnitsky in Stochastic Process Appl 130(7):4470–4492, 2020) except for hyperrectangles or index sets in the lattice case. Using the recent extension of the spectral measure for star-shaped equipped space (Segers et al. in Extremes 20:539–566, 2017), the $$\Upsilon$$
Υ
-spectral tail measure provides a natural extension that describes the clustering effect in full generality.
Breast density in NF1 women: a retrospective study
Authors: De Santis R. , Cagnoli G. , Rinaldi B. , Consonni D. , Conti Beatrice , Eoli M. , Liguori A. , Cosentino M. , Carrafiello G. , Garrone O. , Giroda M. , Cesaretti C. , Sfondrini M.S. , Gambini D. , Natacci F. 
Published: January 2024

AbstractNeurofibromatosis type 1 (NF1) is an autosomal dominant condition caused by neurofibromin haploinsufficiency due to pathogenic variants in the NF1 gene. Tumor predisposition has long been associated with NF1, and an increased breast cancer (BC) incidence and reduced survival have been reported in recent years for women with NF1. As breast density is another known independent risk factor for BC, this study aims to evaluate the variability of breast density in patients with NF1 compared to the general population. Mammograms from 98 NF1 women affected by NF1, and enrolled onto our monocentric BC screening program, were compared with those from 300 healthy subjects to verify differences in breast density. Mammograms were independently reviewed and scored by a radiologist and using a Computer-Aided Detection (CAD) software. The comparison of breast density between NF1 patients and controls was performed through Chi-squared test and with multivariable ordinal logistic models adjusted for age, body mass index (BMI), number of pregnancies, and menopausal status.breast density was influenced by BMI and menopausal status in both NF1 patients and healthy subjects. No difference in breast density was observed between NF1 patients and the healthy female population, even after considering the potential confounding factors.Although NF1 and a highly fibroglandular breast are known risk factors of BC, in this study, NF1 patients were shown to have comparable breast density to healthy subjects. The presence of pathogenic variants in the NF1 gene does not influence the breast density value.
The role of an Ascophyllum nodosum extract in lowering the environmental impact and improving nitrogen use efficiency in pasture systems under a reduced nitrogen regime
Authors: Quille Patrick , Kacprzyk Joanna , O’Connell Shane , Ng Carl K.-Y. 
Published: January 2024

AbstractNitrogen is a macronutrient that is applied in substantial amounts as a chemical fertiliser to conventional agricultural systems. However, loss of nitrogen from agricultural systems to the environment, in the form of gases (N2O) and leachate (NO3), is detrimental to the environment. As such, improving the nitrogen use efficiency (NUE) of crops is an essential component of sustainable agriculture. Biostimulants are a category of products that improve NUE when applied to crops and/or soil. Here, we examined the effects of PSI-362, an Ascophyllum nodosum biostimulant mixed with and applied on calcium ammonium nitrate (CAN) granules, on grass yield, quality traits, and environmental impacts in lysimeter trials under natural weather conditions. By using PSI-362, it was possible to reduce nitrogen application by 25% without a significant loss in yield compared to a conventional 100% N system. We also observed an increase in NUE under a 75% N with PSI-362 co-application fertilisation regime, and a significant increase in crude protein content compared to the 100% N fertilisation controls. Furthermore, this reduced nitrogen application also resulted in reduced nitrogen loss through leachate (NO3) and N2O to the atmosphere. The total NUE for PSI-362 + fertiliser granules ranged from 58.7% to 78.6% depending on the biostimulant dose, which was significantly better than the fertiliser alone. Our results showed that this biostimulant, which can easily be incorporated into conventional agronomic practices, allows for a more sustainable approach to pasture-based systems.
High-temperature sensitivity complex dielectric/electric modulus, loss tangent, and AC conductivity in Au/(S:DLC)/p-Si (MIS) structures
Authors: Tataroglu A. , Durmuş H. , Vahid A. Feizollahi , Avar B. , Altındal Ş. 
Published: January 2024

AbstractComplex dielectric (ε* = ε′ − jε″)/electric modulus (M* = M′ + jM″), loss tangent (tanδ), and ac conductivity (σac) properties of Au/(S-DLC)/p-Si structures were investigated by utilizing admittance/impedance measurements between 80 and 440 K at 0.1 and 0.5 MHz. Sulfur-doped diamond-like carbon (S:DLC) was used an interlayer at Au/p-Si interface utilizing electrodeposition method. The capacitance/conductance (C/G) or (ε' ~ C) and (ε″ ~ G) values found to be highly dependent on both frequency and temperature. The increase of them with temperatures was attributed to the thermal-activated electronic charges localized at interface states (Nss) and decrease in bandgap energy of semiconductor. The observed high ε′ and ε″ values at 0.1 MHz is the result of the space/dipole polarization and Nss. Because the charges are at low frequencies, dipoles have sufficient time to rotation yourself in the direction of electric field and Nss can easily follow the ac signal. Arrhenius plot (ln(σac) vs 1/T) shows two distinctive linear parts and activation energy (Ea) value was found as 5.78 and 189.41 from the slope; this plot at 0.5 MHz is corresponding to low temperature (80–230 K) and high temperature (260–440 K), respectively. The observed higher Ea and ε′ (~ 14 even at 100 kHz) show that hopping of electronic charges from traps to others is predominant charge transport mechanism and the prepared Au/(S:DLC)/p-Si structure can be used to store more energy.