bluuebunny/crossref_metadata_2025_split huggingface dataset:
Single-procedure 8Fr Rheolytic Pharmacomechanical Thrombectomy for Treatment of Acute Iliofemoral Deep Venous Thrombosis
Authors: Xiao Nicholas , Genet Matthew , Karry Rocio Marquez , Hohlastos Elias , Karp Jennifer , Desai Kush R 
Published: December 2023

Abstract
Purpose
We hypothesize that single-procedure venous-specific rheolytic thrombectomy for treatment of acute iliofemoral deep venous thrombosis (DVT) will result in improved clinical symptoms as measured by the venous clinical severity score (VCSS), as well as durable venous patency, with decreased hemorrhagic risks and costs associated with conventional catheter-directed therapy and prolonged lytic exposure.
Materials and Methods
Thirty-three consecutive patients with symptomatic, unilateral, iliofemoral DVT who were treated with single-procedure therapy using the 8Fr rheolytic thrombectomy catheter were retrospectively analyzed from 2012-2021. Abstracted data included technical success (>95% clearance of acute thrombus), adverse events (AEs), and clinical and imaging outcomes at 1-month and 1-year.
Results
Technical success was achieved in all 33 patients. Mean pre-procedure VCSS was 7.5 with mean edema and pain sub-scores of 2.6 and 1.8, respectively. Post-procedural total mean VCSS at one month was significantly improved (mean post-procedure VCSS=0.3, mean reduction of 7.2, P<0.01). Clinical improvement was sustained at 1-year (mean total VCSS=0.2, P<0.01). Primary patency was achieved in all patients at 1-month and 30 (91%) patients at 1-year. Among the 3 patients in which primary patency was not achieved at 1-year, primary-assisted patency was achieved in 2 patients. Secondary patency was achieved in the remaining patient at 1-year. No hemorrhagic AEs occurred in this study.
Conclusion
This study suggests that single-procedure venous-specific rheolytic thrombectomy for treatment of acute iliofemoral DVT is safe and effective, resulting in durable clinical and radiographic results at one year, while also limiting hemorrhagic risks, mitigating costs of admission, and expediting patient discharge.
Effects of Pulmonary Rehabilitation on Functional and Psychological Parameters in Post-Acute Sequelae of SARS-CoV-2 Infection (PASC) Patients
Authors: Nasrullah Adeel , Virk Shiza , Javed Anam , Shah Aaisha , Ramanujam Deeksha , Sharma Alisha , Gutierrez Laura , Nauer Kevin , Maggio Mindy , Yin Yue , Bajwa Yousaf , Cheema Tariq , Disilvio Briana 
Published: December 2023

Abstract
Background
COVID-19 survivors may develop long-term symptoms of fatigue, dyspnea, mental health issues, and functional limitations: a condition termed post-acute sequelae of COVID-19 (PASC). Pulmonary rehabilitation (PR) is a recommended treatment for PASC; however, there is a lack of data regarding PR’s effect on multiple health indices and the factors that influence patient outcomes.
Methods
We extracted patient demographic, comorbidity, and outcome data from Allegheny Health Network’s electronic medical records. Functionality test results were compared before and after PR, including 6-minute walk test (6MWT), chair rise repetitions (CR reps), timed up and go test (TUG), gait speed (Rehab gait), modified medical research council scale (MMRC), shortness of breath questionnaire (SOBQ), hospital anxiety and depression scale (HADS) and chronic obstructive pulmonary disease assessment test (CAT) scores. Multiple regression analysis was done to evaluate the effect of comorbidities and patient factors on patient responses to PR.
Results
The 55 patients included in this study had a mean time of 3.8 months between the initial COVID-19 diagnosis and the subsequent PASC diagnosis. Post-PR, patients signficantly improved in 6MWT, CR reps, TUG, Rehab gait, MMRC, SOBQ, HADS, and CAT scores. However, hypertension, diabetes, chronic lung diseases, being an outpatient, and receiving pharmacologic treatments (decadron, decadron + remdesivir, and decadron + remdesivir + tocilizumab) were associated with a poor response to PR.
Conclusion
Our study supports PR as an integrated model of care for PASC patients to improve several physical and mental health indices. The long-term effects of PR on patients’ functional status should be investigated in the future.
Making Big Business Everybody’s Business: Aboriginal leaders’ perspectives on the commercial determinants of Indigenous health in Victoria, Australia
Authors: CROCETTI ALESSANDRO CONNOR , Yorta) Troy Walker (Yorta , (Mununjali) Fiona Mitchell , (Wotjobaluk) Simone Sherriff , Islander) Karen Hill (Torres Strait , (Wakaya) Yin Paradies , Backholer Kathryn , Browne Jennifer 
Published: December 2023

Abstract
Background
The commercial determinants of health is a rapidly expanding field of research; however Indigenous perspectives remain notably underrepresented. For Indigenous peoples the intersection of globalisation, colonialism and capitalism may amplify commercially-driven health inequities. This study aimed to understand the perspectives of Aboriginal leaders in Victoria, Australia, regarding the impact of commercial entities and their practices on Aboriginal health and wellbeing.
Methods
Semi-structured interviews with 23 Aboriginal leaders from across five sectors (n = 15 urban, n = 8 rural/regional) were analysed through reflexive thematic analysis.
Results
Five overarching themes were identified, encompassing i) the adverse impacts of industries on Aboriginal peoples, ii) the intersection between colonialism and western economic paradigms, iii) tokenistic corporate engagement with Aboriginal communities, iv) supporting Aboriginal-owned businesses, and v) opportunities for self-determination through business. Participants expressed concern over aggressive marketing by the gambling industry, the exploitation of Aboriginal culture by commercial industries, the privatisation of public services, and the lack of oversignt of corporate social responsibility strategies. Simultaneously, Aboriginal-led businesses were viewed as opportunities for cultural and financial empowerment and self-determination.
Conclusion
Numerous commercial actors and practices are perceived to influence Aboriginal health and wellbeing. This study highlights the need for strong policy and regulation to mitigate harmful industry practices while incentivising the potential positive impacts of the commercial activities on Aboriginal health and wellbeing.
Mechanical Performance Comparisons of Flyash and GGBFS Concrete Proportions in Ambient Temperature with Conventional Concrete
Authors: Deshamukh satalingappa , S Manjunatha G 
Published: December 2023

Abstract
By reacting alkaline solution with silicon, alumina, calcium products and forms the Geopolymer concrete. A number of experiments were conducted by heat curing to find the suitable proportion of Flyash and GGBSto get the desired strength with conventional concrete. Here By conducting short-term and long-term tests, efforts to find the most suitable proportion of Flyash and GGBFS give the closest strength results to conventional concrete in ambient temperature. In this study, using GPC (geopolymer concrete) mixes of 75%:25%, 70%:30%, 65%:35%, and 60%:40% (Flyash: GGBS) and M20 grade concrete, here conducted mechanical and durability tests.
Combination therapy of fasudil hydrochloride and ozagrel sodium for treating patients with aneurysmal subarachnoid hemorrhage: a cross-sectional study using a nationwide inpatient database
Authors: Magara Hiroshi , Tani Takuaki , Imai Shinobu , Kiyomi Anna , Fushimi Kiyohide , Sugiura Munetoshi 
Published: December 2023

Abstract
No definitive conclusions have been drawn yet regarding the clinical efficacy of fasudil hydrochloride and ozagrel sodium monotherapy or their combination for subarachnoid hemorrhage (SAH). Therefore, we conducted this cross-sectional study using the Diagnosis Procedure Combination data to investigate the prognostic effects of the combined administration of fasudil hydrochloride and ozagrel sodium in Japanese patients with SAH. The participants were patients who were hospitalized with subarachnoid hemorrhage and received fasudil hydrochloride or ozagrel sodium between April 1, 2016, and March 31, 2020 (n = 17,346). The participants were divided into the fasudil hydrochloride monotherapy (F group, n = 10,484), ozagrel sodium monotherapy (O group, n = 465), and fasudil hydrochloride and ozagrel sodium combination therapy (FO group, n = 6,397) groups. The primary outcome was in-hospital mortality, and the secondary outcome was the proportion of patients with modified Rankin Scale (mRS) score ≤ 2 at discharge. Multivariable adjusted logistic regression analysis (significance level, 5%) was used for data analyses. With the F group as the reference, the adjusted odds ratio (OR) for in-hospital mortality was 0.99 for the FO group (95% CI: 0.86–1.14, p = 0.883) and 2.63 for the O group (95% CI: 1.95–3.56, p < 0.001). The OR for the proportion of patients with mRS score ≤ 2 at discharge was 0.93 for the FO group (95% CI: 0.86–1.00, p = 0.037) and 0.79 for the O group (95% CI: 0.64–0.98, p = 0.035). Our results indicate that prognosis tended to be better with their combined use compared to ozagrel sodium monotherapy.
Enhancing the electromagnetic forming performance of thin-walled sheet metal via a thicker driver: Forming behavior and experimental validation
Authors: Xu Wei , Lai Zhipeng , Gong Mengyuan , Li Changxing , Hu Yang , Zhang Zixuan , Cao Quanliang , Han Xiaotao , Li Liang 
Published: December 2023

Abstract

This paper proposes an innovative electromagnetic forming approach for die-forming of sheet metal parts with a low thickness-to-diameter ratio (0.25%), in which an additional driver sheet was used to improve the forming behavior. Numerical simulations reveal that the conventional EMF method fails to prevent wrinkling defects in thin-walled sheet metal forming, with the severity of wrinkles increasing as the voltage rises. These wrinkles reach a maximum height of 11.3mm and result in inadequate workpiece adherence to the die. To address these challenges, a novel technique is introduced that effectively suppresses wrinkling by enhancing the interaction between the driver sheet and the workpiece. Through a comprehensive evaluation of forming efficiency and wrinkle suppression, an optimal driver sheet thickness of 3mm is determined, minimizing wrinkling to 0.67mm. Compared to the conventional EMF method, the proposed approach yields a fuller and more accurate forming results, closely conforming to the die contour. The process window is defined by analyzing two fundamental process parameters: blank holder force (FBHF) and discharge voltage (Vd). The deformation history of the driver sheet EMF is examined for a high forming quality case with Vd = 12kV and FBHF = 8 kN, resulting in 1.41mm die-fitting gaps. A comparative experimental study demonstrates the effectiveness of the driver sheet EMF technique in producing deep-cavity workpieces with superior forming accuracy. The results include a maximum die-fitting gap of 1.41mm and a maximum wrinkle height of 0.67mm. The proposed driver sheet EMF method exhibits enhanced flexibility and efficiency compared to the conventional EMF, particularly in manufacturing extremely thin-walled sheet metal parts.
Assessing the Consistency of Landslide Susceptibility Models: Frequency Ratio, Logistic Regression, Artificial Neural Network, and Random Forest
Authors: Chiang Shou-Hao , Chu Van-Trung , Lin Tang-Huang 
Published: December 2023

Abstract
Several models have been proposed to analyze landslide susceptibility, including physically-based models, index-based models, statistical models, and machine-learning algorithms. Previous studies focusing on model comparison mainly determined a better model based on predicting accuracies. In this study, we suggest a better model should not only produce results with higher accuracy but also be consistent in its performance. This study aims to provide a new perspective to assess the model performance, by analyzing the consistency of modeling outcomes. This requires multiple modeling trails. Specifically, four commonly used models were selected and tested, including frequency ratio (FR), logistic regression (LR), artificial neural network (ANN), and random forest (RF). The study area is the Thu Lum basin, located in the mountainous range of Lai Chau Province, Viet Nam. This study applied 13 predisposing factors, and the model training and testing procedures were randomly performed multiple times, from 5 times to 50 times for each model. Seven accuracy indexes were used to summarize and assess model consistency. We also explored the consistency of each factor’s contribution in different models. The result shows that 10 independent modeling trials are acceptable to reveal the model consistency, and among the four models, the RF model is considered the best one because it consistently produces higher accuracies. However, it also shows inconsistent importance rank of predisposing factors in different trials, which leads to higher uncertainty in explaining the landslide environment. To address this issue, we suggest finding consensus from multiple modeling outcomes could be a more reliable approach. We expect this study can be a useful reference for determining a suitable model for analyzing landslide susceptibility in a given area.
Profiles of Immunosuppressive Nonadherence and Association between Medication Adherence and Tacrolimus Intra-patient Variability Among Stable Kidney Transplant Recipients
Authors: Zou Zhiyu , Dai LinRui , Hou Yi-bo , Yu Chen-zhen , Chen Ren-jie , Chen Song , Chang Sheng , Zhang Wei-jie 
Published: December 2023

Abstract
Background
Understanding the modifiable correlates and risk factors for medication non-adherence is essential to develop interventions to improve adherence and thus long-term transplantation outcomes.
Methods
This single-center cross-sectional study collected 409 validated questionnaires of renal transplant recipients followed in outpatient clinics. The incidence of nonadherence to immunosuppressive therapy (implementation phase) was calculated. Multilevel correlates associated with nonadherence were collected to analyze multilevel correlates of nonadherence in kidney transplant recipients. The relationship between nonadherence and recipient outcomes was also explore.
Results
The incidence of nonadherence to immunosuppressive drugs in renal transplant recipients was 41.6%. Multiple logistic regression analysis showed that 4 variables were positively associated with immunosuppressive nonadherence, namely without steady partner (OR: 1.722; 95%CI: 1.034–2.866), post-transplant years (OR: 1.240; 95%CI: 1.134–1.356), twice-daily immunosuppressive regimen (OR: 5.522 95%CI: 2.857–10.671), Tac IPV (OR: 1.029 95%CI: 1.007–1.052). There was a significant difference in Tac IPV between the adherent and nonadherent groups. The incidence of rejection was 4.2% (10/239) in the adherent group and 12.4% (21/170) in the nonadherent group(p = 0.002). In addition, nonadherence (OR: 2.967, 95%CI: 1.248–7.058) and Tac IPV (OR: 1.030, 95%CI: 1.001–1.060) were positively correlated with episodes of rejection.
Conclusion
The higher incidence of immunosuppression nonadherence in renal transplant recipients correlates with lacking a steady domestic partner, longer time since the transplantation, higher frequency of immunosuppressive dosing, and higher Tac IPV. In addition, nonadherence and higher tacrolimus IPV were correlated with episodes of rejection. Tacrolimus IPV can be an additional instrument for identifying recipients at risk of nonadherence.
Survey of OB/GYN Residents Knowledge and Practice of Trauma Informed Care
Authors: Stokes Lauren , Burgess Adriane , Burcher Paul 
Published: December 2023

Abstract
Background
There is a high prevalence of a history of traumatic experiences among those seeking obstetric/gynecologic care. OB/GYN clinicians must use trauma-informed care practices to avoid re-traumatization and to provide supportive care. The objective of this study was to describe the knowledge and use of trauma-informed care practices by OB/GYN residents in the outpatient setting.
Methods
A descriptive research design was used. In February 2022, an email will a link to an electronic survey was sent to US OB/GYN residency program directors via listserv. Residency directors were asked to forward the survey to residents in their program subsequently, we were unable to calculate the response rate. The survey included closed response questions some of which were Likert scale to assess the frequency of use of certain trauma-informed care practices during the provision of pelvic examinations.
Results
Seventy US OB/GYN residents responded to the survey. Only half of residents surveyed reported that they practiced trauma-informed care and half reported either not receiving education or were not sure if they had training on the subject. Additionally, half of the respondents were not aware of the ACOG Committee Opinion 825: Care of Patients with History of Trauma.
Conclusion
There was limited use of trauma-informed care practices among OB/GYN residents in this study. Considering the high prevalence of traumatic experiences among individuals seeking gynecologic care, a framework for trauma-informed pelvic exams should be included in the residency curriculum and applied universally.
Pan-cancer analysis of the oncogenic effects of ribosomal protein L13 (MRPL13) and validation in hepatocellular carcinoma
Authors: CAI xin , Li Minghao , Gao Jie , Zhang Huapeng , Zhang Jiakai , Zhang shuijun , Zhang Yi 
Published: December 2023

Abstract
Purpose
Mitochondrial ribosomal protein 13 (MRPL13) belongs to the large family of mitochondrial ribosomal proteins, and mitochondrial ribosomal protein (MRPL) genes are involved in a variety of cellular processes, including cell proliferation, apoptosis, and cell cycle. Numerous studies have demonstrated the importance of MRPL13 in tumorigenesis, but no systematic pan-cancer analysis has been performed.
Methods
The aim of this study was to investigate the prognostic and immune functions of MRPL13 through bioinformatics analysis of datasets from the Cancer Genome Atlas, UALCAN, GEPIA2, cBioPortal, TIMER2, and the Human Protein Atlas. Expression of MRPL13 was correlated with prognosis, tumor mutational burden, immune cell infiltration, drug prediction, and oncogenic pathways.
Results
MRPL13 has been found to be highly expressed in various types of cancers and is associated with poor prognosis. Patients with high MRPL13 expression have higher levels of Th2 cell infiltration and may respond better to immunotherapy. In HCC, MRPL13 is highly expressed and may promote cell proliferation by regulating cell cycle progression. In conclusion, the present study suggests that MRPL13 is a reliable prognostic and immunotherapeutic biomarker, and is particularly promising as a therapeutic target for HCC.
Conclusion
In conclusion, the present study demonstrates that MRPL13 is upregulated in a wide range of cancers and has reliable diagnostic and prognostic value. In addition, MRPL13 may also play an important role in the tumor immune microenvironment, as verified by the following results: overexpression of MRPL13 was associated with high immunogenicity of tumors, suggesting a possible benefit of immunotherapy. We also identified potentially effective therapeutic agents such as BI-325 and darbepoetinide for patients with high MRPL13 expression, who are more likely to be sorafenib and TACE resistant. In HCC, MRPL13 promotes cell cycle progression and proliferation in liver cancer. These findings highlight the potential significance of MRPL13 as a predictive biomarker for prognosis and response to immunotherapy in cancer patients, and in particular provide a new therapeutic target for HCC.
Mitigating Data Exfiltration Ransomware through Advanced Decoy File Strategies
Authors: Liu Shishi , Chen Xin 
Published: December 2023

Abstract
This study introduces an advanced decoy file strategy utilizing Generative Adversarial Networks (GANs) to combat data exfiltration ransomware threats. Focused on creating highly realistic decoy documents, the system embeds these across enterprise networks, engaging ransomware threats effectively. It includes real-time monitoring for abnormal interactions and proactive response mechanisms for threat containment. Rigorous testing against various ransomware samples demonstrated high engagement rates and rapid response times, confirming the system's effectiveness. Integration across diverse network types was achieved with minimal operational overhead. This study highlights the system's adaptability in the face of evolving ransomware tactics and underscores the balance between decoy realism and deployability.
Untangling the Use of Blockchain in Distributed AgriFood Supply Chains: IoT data privacy and ABAC policy smart contract
Authors: Pesanhane Hélio , Westphall Carlos 
Published: December 2023

Abstract
Blockchain is portrayed as a technology capable of solving problems of transparency, traceability, data tampering and accountability in the Agrifood supply chain. However, the transparency provided brings privacy issues and furthermore, this sector is characterized by the use of IoT devices for process automation, and these devices have problems of limited performance, mobility, etc, making it difficult to manage the large scale IoT environment using current security, authentication and access control solutions. To address these challenges, the work proposes an architecture for storing private data, allowing only authorized participants to have access. These data are stored by IoT devices in the participant’s cloud after its transaction has been validated by the endorsing peers and in accordance with the attribute-based access control (ABAC) policy that allows the IoT device owners configure the physical quantities, the range of values, time period, body type, that each device is allowed to measure and transmit. An user can be authorized to read IoT data under the ABAC policy contract. 50% of IoT 1 Springer Nature 2021 L A T E X template Article Title data write requests are performed and answered in less than 0.14 seconds and 2.5 seconds using solo and raft ordering service, respectively. On the other hand, data retrieval had a average latency ranging from 0.34 to 0.57 seconds and throughput from 124.8 to 9.9 Transactions Per Second (TPS) for data sizes ranging from 8 to 512 kilobytes.
Design, Optimization and Evaluation of Intranasal Nanotherapeutic of Atypical Antipsychotic Drug
Authors: PONDURI TEJA KUMAR , GUNTUPALLI CHAKRAVARTHI , JEGANATHAN BALAMURUGAN 
Published: December 2023

Abstract
Objective: The current study manifests the successful optimization and delivery of chitosan nanoparticles utilizing the nasal route to overcome inherent issues of ziprasidone hydrochloride, an atypical antipsychotic drug to curtail its bioavailability problems.Materials & Methods: Chitosan nanoparticles were prepared by ionic gelation technique and optimized using Box–Behnken design. In vitro drug release kinetics and ex vivo nasal permeation potential were determined.Results & Discussion: Chitosan nanoparticles exhibited a mean particle size of 153.8 ± 13.3 nm, a mean polydispersity index of 0.433 ± 0.15; an Entrapment Efficiency of 87.3 ± 3.62%, and a Drug loading capacity of 8.7 ± 0.25%. Transmission electron microscopy examinations revealed spherical particle size with uniform drug distribution. The physicochemical stability of nanoparticles was evaluated for 12 weeks, and they showed good stability at 25 ± 2°C/60 ± 5% RH. In vitro release studies established the supremacy of nanoparticles compared to drug suspension with cumulative drug release of 89.93% in pH 6.4 and 87.16% in pH 7.4. Ex vivo nasal permeation studies revealed a 5.26-fold increment in nasal permeation by nanoparticles, and the cumulative amount of drug permeated through nasal mucosa from nanoparticles was 2.58 ± 0.13 µg/cm2 × 10–2 compared to 1.02 ± 0.091 µg/cm2 × 10–2 from the drug suspension.Conclusion: Thus, in vitro and ex vivo results from nanoparticles showed remarkable potential in improving solubilization fate and nasal permeation of ziprasidone, thereby leading to prospective in vivo fate in enhancing brain delivery of ziprasidone.