bluuebunny/crossref_metadata_2025_split huggingface dataset:
Predictive model of pre-operative prognostic nutrition index for biochemical recurrence in patients undergoing robot-assisted laparoscopic radical prostatectomy: a retrospective clinical study
Authors: Zhao Yifan , Qian Shian , Li Xianchuang , Jin Hengxi , Zhao Xiaojun 
Published: January 2024

Abstract
Objective: To investigate the predictive value of pre-operative prognostic nutritional index (PNI) in biochemical recurrence (BCR) in patients with robot-assistedlaparoscopic radical prostatectomy (RARP) and to establish a BCR risk score model based on PNI.
Methods: The clinical data of 157 patients treated with RARP in the Department of Urology, the First Affiliated Hospital of Soochow University were retrospectively analyzed. The endpoint of observation was BCR. The area under the receiver operating characteristic (ROC) curve was evaluated to determine the optimal cutoff value for PNI. Kaplan-Meier analysis and Cox regression analysis were used to evaluate the correlation between PNI and BCR. 157 patients were divided into a training group and a validation group by a ratio of 7:3. By univariate and multivariate Cox regression analysis, independent prognostic factors were screened from the relevant clinicopathological factors, a BCR prediction model and nomogramwere established, then verified its value.
Results: According to the ROC curve, the optimal cutoff value of PNI for 157 patients in this study was 47.425. According to multivariate Cox regression analysis, PNI and prostate-specific antigen (PSA) were identified as independent prognostic factors for predicting BCR in patients treated with RARP. A BCR prediction model formula was established based on PNI and PSA. It was proved to have good predictive value in both the training group and the validation group. Nomogram was constructed to predict the BCR of patients treated with RARP at 6-, 12-, and 24-months after surgery. The results of the calibration plots showed that the nomogram performed well in the training group and the validation group.
Conclusion: PNI is an independent prognostic factor for predicting BCR in patients treated with RARP. The scoring model and nomogram based on PNI and PSA can effectively predict the risk of BCR in patients treated with RARP.
Large field-of-view intravascular ultrasound for actual valve-in-valve transcatheter heart valve expansion. A Pilot study.
Authors: Kalińczuk Łukasz , Mintz Gary S , Skotarczak Wiktor , Sadowski Karol A , Stokłosa Patrycjusz , Kochańska Sara , Dąbrowski Maciej , Woźniak Olgierd , Kubik Agata , Kowalik Ilona , Sondergaard Lars , Witkowski Adam , Michałowska Ilona , Demkow Marcin 
Published: January 2024

Abstract
Background. Actual expansion of a transcatheter heart valve (THV) might differ from nominal particularly during non-aortic valve-in-valve (VIV) for degenerated bioprosthetic surgical heart valve (SHV).
Aims. To compare THV expansion measured using large-field-of-view intravascular ultrasound (IVUS) versus multi-slice computer tomography (MSCT) and assess the correlation between THV dimensions and transvalvular gradients.
Methods. Fourteen patients were successfully treated with mitral/tricuspid VIV SAPIEN 3 implantation sized using the true SHV inner diameter; all 14 had baseline MSCT and transvalvular gradients measured at baseline, post-procedure, and at discharge. Peri-procedural IVUS (in 6 patients using with a Philips 10MHz Vision PV035) was compared with post-procedural MSCT (in 9 patients) with offline measurements performed at 1-mm steps along the THV height, and analyzed 190 MSCT and paired 124 IVUS cross-sections.
Results. There was very good agreement between IVUS THV dimensions and corresponding MSCT measurements (intraclass correlation coefficient ≥0.986 and p<0.001). IVUS measured THV expansion (percent of the nominal cross-sectional area) was smaller within the inflow and middle of the THV overlapping the ring (85.9±11.3%, 83.8±11.8%) than within the outflow (98.8±12.7%). The residual mean transvalvular gradient increased from peri-procedural to pre-discharge (3.5±2.0 vs 6.3±1.7mmHg, p<0.001). The only independent predictor of pre-discharge maximal transvalvular gradient was the smallest minimal inner THV frame diameter (r2=0.67), predicted by true SHV internal diameter (Beta = 0.066, 95%CI = 0.015 – 0.117, r2=0.49, p=0.037).
Conclusions. Peri-procedural use of a large field-of-view IVUS offers accurate insight into actual THV expansion when deployed valve-in-valve. Minimal inner THV stent frame dimensions correlate with increased post-procedural transvalvular gradients.
Arterial blood pressure monitoring using three different technologies during neuro radiological procedure: a prospective, monocentric, observational study
Authors: Chapalain Xavier , Morvan Thomas , Gentric Jean-Christophe , Subileau Aurélie , Jacob Christophe , Cadic Anna , Caillard Anaïs , Huet Olivier 
Published: January 2024

Abstract

Background
In the perioperative setting, the most accurate way to continuously measure Arterial Blood Pressure (ABP) is using an arterial catheter. Surrogate methods such as finger cuff have been developped to allow non invasive measurements and are increasingly used, but needs further evaluation. The aim of this study is to evaluate accuracy and clinical concordance between three devices for the measurement of ABP during neuroradiological procedure.
Methods
This is a prospective, monocentric, observational study. All consecutive patients undergoing a neuro radiological procedure were eligible. Patients who needed arterial catheter for blood pressure measurement were included. During neuroradiological procedure, ABP (systolic, mean and diatolic blood pressure) was measured with three different technologies: radial artery catheter, Arm Cuff and Nexfin. Bland-Altman and error grid analysis were performed to evaluat accuracy and clinical concordance between devices.
Results
From March 2022 to November 2022, we included 50 patients, mostly ASA 3 (60%) and required a cerebral embolization (94%) under general anaesthesia (96%). Compare to artery catheter, a significant relationship was found for SAP (r2 = 0.78) and MAP (r2 = 0.80) with the Nexfin (p < 0.001). Bias and limits of agreement (LOA) were respectively 9.6 mmHg (-15.6 to 34.8 mmHg) and − 0.8 mmHg (-17.2 to 15.6 mmHg), for SAP and MAP. We found a significant relationship for SAP (r2 = 0.82) and MAP (r2 = 0.74) with Arm Cuff (p < 0.001). Bias and LOA were respectively 5.8 mmHg (-30.4 to 22.9 mmHg) and − 1.4 mmHg (-17.3 to 14.4 mmHg), for SAP and MAP. Error grid analysis showed that 99% of non-invasive ABP measures obtained with the Nexfin and Arm Cuff were located in the risk zone A or B.
Conclusions
Despite an inaccuracy which are larger than acceptable, ABP measurement with non-invasive devices induced almost no changes in individual patient care during neuro radiological procedure.
Trial registration:
Clinicaltrials.gov, registration number: NCT05283824
Enhancing the Robustness of Hybrid Metal-Composite Connections through 3D printed Micro Penetrative Anchors
Authors: Raimondi Luca , Tomesani Luca , Zucchelli Andrea 
Published: January 2024

Abstract
This work proposes a novel solution for manufacturing hybrid metal-composite joints, in which different pin shapes are evaluated for their capability to penetrate long carbon fiber epoxy composites successfully and for the mechanical behavior determined by each configuration. On the metal side, pins are manufactured by Laser Powder Bed Fusion (LPBF), downsizing the currently adopted solutions and, at the same time, developing new blocking features aimed at enhancing the mechanical properties of the joint. The different configurations were evaluated in two distinct experiments: the first to evaluate the induced defects in the composite substrate and the second to characterize the mechanical behavior of the joint. It emerges that smaller pins produce much less damage and misalignments in the composite structure with respect to the conventional pin solution, whereas the new "blocking features" configurations consistently increase maximum pullout load and energy with respect to the conventional pin solution, with the same level of fiber damage.
Clinical Features Associated with Immune Checkpoint Inhibitor Nephritis: A Single-Center Clinical Case Series
Authors: Muddasani Ramya , Talwar Neel , Mambetsariev Isa , Fricke Jeremy , Lin Mercury , Schmolze Daniel , Yue Andrew , Rizvi Amna , Salgia Ravi 
Published: January 2024

Abstract

Background
Acute kidney injury (AKI) has been well described as a complication of immune checkpoint inhibitor therapy. We present a series of patients, the majority with lung adenocarcinoma, who developed AKI while actively receiving immune checkpoint inhibitors.
Methods
This is a retrospectively analyzed clinical case series of six patients treated at City of Hope Comprehensive Cancer Center. Data was collected on gender, age, ethnicity, comorbidities, concomitant medications, type of malignancy, treatments, and renal function. All patients underwent renal biopsy for classification of the mechanism of AKI. Comprehensive genomic profiling (CGP) was performed on tumor tissue for all patients.
Results
Patterns of AKI included acute interstitial nephritis and acute tubular necrosis. Contributing factors included the use of concomitant medications known to contribute to AKI. All but two patients had full resolution of the AKI with the use of steroids. There were several mutations found on CGP that were notable including an Exon 20 insertion as well as multiple NF1 and TP53 mutations. There was high PD-L1 expression on tumor tissue noted in two out of six patients. In addition to AKI, a subset of patients had proteinuria with biopsies revealing corresponding glomerular lesions of minimal change disease and focal and segmental glomerulosclerosis.
Conclusions
Our case series demonstrates that AKI from immune checkpoint inhibitors has a variable presentation that may require an individualized treatment approach. Further studies are needed to identify biomarkers that may help identify those at risk and guide the management of this condition.
Screening for SARS-CoV-2 and other coronaviruses in urban pigeons (Columbiformes) from the North of Spain under a ‘One Health’ perspective
Authors: Portillo Aránzazu , Cervera-Acedo Cristina , Palomar Ana M. , Ruiz-Arrondo Ignacio , Santibáñez Paula , Santibáñez Sonia , Oteo José A. 
Published: January 2024

Abstract

Coronaviruses have a major impact on human and animal health. As an example, SARS-CoV-2, a Beta-coronavirus responsible for the COVID-19 pandemic, continues circulating and causing human deaths, and its high replication rate results in numerous variants. Coronaviruses are adapted to birds and mammals and constitute serious threats. They are able to accumulate mutations, and the emergence of new viruses by recombination of SARS-CoV-2 with other coronaviruses is likely. Urban pigeons (Columbiformes) are synanthropic birds of great interest from a "One Health" perspective, due to their interaction with humans and other animals. Aware that pigeons may act as reservoirs of viruses and contribute to their spread, we aimed to investigate the possible presence of SARS-CoV-2 and other coronaviruses in pigeons in Logroño city, Spain. Oropharyngeal and cloacal swabs from 203 Columbiformes were collected in August/September 2021, and January/February 2022. SARS-COV-2 was screened by real-time PCRs targeting N1 in all specimens and, subsequently, targeting E gene in 10% of random samples. In addition, PCRs of two RdRp gene regions from all coronaviruses were performed. SARS-CoV-2 was not detected in any sample, whereas coronavirus RNA was found in 13.3% pigeons. RdRp nucleotide sequences showed maximum similarity (96.1–97.2%) with those of Gamma-coronavirus (Igacovirus), found in Columbiformes, mainly in Finland, Poland and China. Monitoring the emergence of recombinant viruses should continue, since SARS-CoV-2 still circulates and there are other coronaviruses in animals in close contact with humans. The presence of Gamma-coronavirus in urban pigeons must be considered for the risk surveillance of human infections.
The evolution of the genetic structure of populations of two species of the Anopheles gambiae s.l. complex using the Kdr gene before and after indoor residual spraying in some agroecological zones of Benin (West Africa)
Authors: Koukpo Come Z. , Fassinou Arsène Jacques Y. H. , Ossè Razaki A. , Tokponon Filemon , Agossa Fiacre R. , Padonou Germain Gil , Govoetchan Renaud , Aboubakar Sidick , Yovogan Boulais , Odjo Esdras M. , Akpodji Serge , Adoha Constantin J. , Baba-Moussa Lamine Saïd , Adégnika Ayola Akim , Akogbeto Martin C. , Sezonlin Michel 
Published: January 2024

Abstract
In Benin, the resistance of An. gambiae s.l. mosquitoes to pyrethroids remains a major concern. The development and use of alternative insecticides seems to be the solution. Organophosphates (Actelic@300 CS) are currently the best candidates to meet this challenge. The present study aims to compare the genetic structure of vector populations of two species of the An. gambiae complex through the L1014F resistance allele of the Kdr gene during two periods marked by characteristic environments to better understand its impact on the dynamics and biology of these organisms. Eight localities divided into three agro-ecological zones, one of which is a control, were studied. Larval surveys were carried out during the rainy seasons from May to July 2016 for the pre-PID period and from May to November 2018 for the subsequent period. Larvae were reared at the insectarium of the Centre de Recherche Entomologique de Cotonou. The adult females obtained were identified morphologically and by molecular approaches. The genetic structure of the populations at various hierarchical levels could be determined using the L1014F and L1014L alleles of Kdr. Molecular analysis revealed three vector species of the An. gambiae complex both before and after IRS, two of which were in the majority. These were 171 An. coluzzii, 297 An. gambiae s.s., 11 An. arabiensis and 211 An. coluzzii, 256 An. gambiae s.s., 8 An. arabiensis respectively out of 479 sampled before treatment and 475 sampled after IRS. In both An. gambiae s.s. and An. coluzzii, the gene frequency of L1014F was found to increase significantly following treatment, approaching the limit of fixation in some populations. A deficit of heterozygosity is widespread with values of the indices, FST, FSC and FCT, expressing little or no differentiation within and between the defined populations. IRS didn’t adversely affect the selection and spread of the L1014F resistant allele of the Kdr gene. The apparent adaptation of An. coluzzii to polluted areas would be a factor in its proliferation to the detriment of its twin sister An. gambiae in IRS areas. The genetic structuring of the populations, whatever the species, remains almost the same despite the treatment.
Gastric emphysema and pneumatosis intestinalis in two common marmosets with duodenal dilation syndrome
Authors: Kawarai Shinpei , Sakai Yasuhiro , Iriki Atsushi , Yamazaki Yumiko 
Published: January 2024

Abstract

Background:Common marmosets (Callithrix jacchus) are widely used as primate experimental models in biomedical research. Duodenal dilation with chronic vomiting in captive common marmosets is a recently described life-threatening syndrome that is problematic for health control. However, the pathogenesis and cause of death are not fully understood.
Case presentation: We report two novel necropsy cases in which captive common marmosets were histopathologically diagnosed with gastric emphysema (GE) and pneumatosis intestinalis (PI). Marmoset duodenal dilation syndrome was confirmed in each case by clinical observation of chronic vomiting and by gross necropsy findings showing a dilated, gas-filled and fluid-filled descending duodenum that adhered to the ascending colon. A diagnosis of GE and PI was made on the basis of the bubble-like morphology of the gastric and intestinal mucosa, with histological examination revealing numerous vacuoles diffused throughout the lamina propria mucosae and submucosa. Immunostaining for prospero homeobox 1 and CD31 distinguished gas cysts from blood and lymph vessels. The presence of hepatic portal venous gas in case 1 and possible secondary bacteremia-related septic shock in case 2 were suggested to be acute life-threatening abdominal processes resulting from gastric emphysema and pneumatosis intestinalis.
Conclusions: In both cases, the gross and histopathological findings of gas cysts in the GI tract walls matched the features of human GE and PI. These findings contribute to clarifying the cause of death in captive marmosets that have died of gastrointestinal diseases.
Application of ARIMA-LSTM-CQP Time Rolling Window Multi-Factor Stock Selection Model in Quantitative Investment
Authors: TANG CHEN , Xu Yidan , Bu Shupo , Xiao Sa , Yuan Bo , Cai Jiarong , Yu Qianhua 
Published: January 2024

Abstract
With the support of big data and artificial intelligence, stock price prediction has been a hot topic, which attracts many scholars to explore and study this field. In this paper, to ensure the validity of the factors in the multifactor stock picking model, the factors of different months are acquired rotationally, and the ARIMA-LSTM-CQP time rolling window multifactor model based on ARIMA-LSTM-CQP is proposed. In this paper, by adding the time rolling window model to the acquired data, the IC values of all the factors in each month are characterised by feature selection and correlation tests, and the factors with high correlation are eliminated to lay a robust foundation for the model prediction. Subsequently, ARIMA, LSTM and CQP algorithms are combined to construct multi-factor model factor combinations, and a time rolling window multi-factor model based on ARIMA-LSTM-CQP is established. The obtained multifactor quantitative stock picking model is used for stock picking strategy research, and the multifactor model and stock picking strategy are evaluated through simulated trading and experimentally compared with DeepForest, RF, LSTM, GBDT and LightGBM machine learning algorithm models. After the experimental study, it was found that the ARIMA-LSTM-CQP time rolling window based multifactor model achieves good results in terms of ACC, F1, Recall, Annualized Return and Maximum Retraction.
Toll-like receptors (TLRs) in PDT-induced innate immune response cervical human papillomavirus infection (HPV)
Authors: Maxim Afanasiev , Alexander Dushkin , Tatyana Grishacheva , Oxana Svitich , Polina Kukina , Asmik Avagyan , Elena Biryukova , Khangeldi Akramal , Karaulov Alexander 
Published: January 2024

Abstract

Purpose
Photodynamic therapy (PDT) has emerged as a promising treatment modality for human papillomavirus (HPV) associated diseases, particularly cervical precancer and cancer, offering a non-invasive approach to disease management.
Methods
In this study, we conducted analysis of mRNA TLR-2, -3, -4, and − 8 expressions in cervical smears before and after PDT. A total of 1187 women underwent PDT, and the study focused on evaluating mRNA expression of TLRs 2/3/4/8 on 125 women.
Results
Our findings demonstrated that PDT triggers the activation of early markers of the antiviral innate immune response within two hours of treatment. This activation, in turn, induces a robust antiviral and antitumor immune response.
Conclusion
This study underscores the potential of PDT as a therapeutic strategy for HPV-associated diseases by harnessing its ability to activate the immune response. The observed reduction in the risk of cancer recurrence, coupled with the induction of an antiviral and antitumor immune response, highlights PDT as a promising approach in the treatment of cervical pathologies associated with HPV infection.
CSFNet: A novel crowd counting network for occlusion and scale variation
Authors: Xiong Liyan , Li Zhida , Huang Xiaohui , Wang Heng , Huang Peng 
Published: January 2024

Abstract
The goal of crowd-counting techniques is to estimate the number of people in an image or video in real-time and accurately. In recent years, with the development of deep learning, the accuracy of the crowd-counting task has been improving. However, this task still faces great challenges in crowded scenarios with large individual size variations. To cope with this situation, this paper proposes a new type of crowd-counting network: Context-Scaled Fusion Network. The details include (1) the design of the Multi-Scale Receptive Field Fusion Module (MRFF Module), which employs multiple dilated convolutional layers with different dilatation rates and uses a fusion mechanism to obtain multi-scale hybrid information to generate higher quality feature maps; (2) The Contextual Space Attention Module ( CSA Module) is proposed, which can obtain pixel-level contextual information and combine it with the attention map to enable the model to autonomously learn and pay attention to the important regions to achieve the effect of reducing the counting error. In this paper, we train and test several publicly available and challenging datasets to evaluate the performance of CSFNet. The experimental results show that CSFNet outperforms many SOTA methods on these datasets, demonstrating its superior counting ability and robustness.
Exploring Riboflavin Quantification in Honey via Spectrofluorimetry: A Statistical Examination of Influential Extrinsic Variables
Authors: Khan Shahab , Khan Maaz , Khan Hamayun , Rahman Hameed Ur , AbdelGawwwad Mohamed Ragab , Elsadek Mohamed Farouk 
Published: January 2024

Abstract
The present study is focused on the collection of honey samples from the different geographical and climatic conditions of Khyber Pakhtunkhwa and analyzing them for determination of riboflavin. Quantification of riboflavin being natively fluorescent, was accomplished using spectrofluorimetric method. Riboflavin has characteristic fluorescence spectra with maximum excitation at 464 nm followed by an emission peak at 525 nm. The procedure followed in this work comprised the construction of a calibration curve by plotting the fluorescence intensity of a series of riboflavin solutions versus concentration. This curve was used for quantification of riboflavin in the collected honey samples. The effect of several external factors such as the altitude of the sampling area, type of honey bee, type of flowers from which the nectar was collected, and sampling season on the concentration of riboflavin in the honey samples was statistically evaluated. It was concluded that the samples collected from lower altitudes have high concentration (1.156±0.08 μg g-1) of riboflavin. Similarly, the samples collected in autumn were found to have a with a maximum average riboflavin concentration of 1.37±0.06 μg g-1, which was higher in comparison to the samples collected in other seasons of the year. Likewise, the effect of flora on the concentration of riboflavin was also investigated and it was found that honey samples collected from areas where the nectar was collected from Ziziphus contains maximum riboflavin concentration averaged at 1.383±0.1 μg g-1. Based on the size of the honey bees the samples collected from hives of small honey bees were found to have maximum riboflavin concentration of 1.176±0.07 μg g-1. This study suggests that beside the studied vitamin, the rest of the vitamins and other nutritional components may vary in the honey samples depending upon external factors.