bluuebunny/crossref_metadata_2025_split huggingface dataset:
A Study on the Deaeration Effect of N2 Nanobubbles Using Friction Tube
Authors: Yoo Taekeun , Yoo Young-Ho , Byun Suk-Joo , You A-Ram , Park Chang-Hee , Choi Dae-Hyun , Jun Eun-Hee , Kim Gi-Han 
Published: January 2024

Abstract
The dissolved oxygen in water has a role in causing oxidation reactions that corrode devices and other objects. Thus, the removal of dissolved oxygen, known as deaeration, is a crucial task in the industry. This study investigated whether it is possible to generate deaerated water with more than 90% dissolved oxygen (DO) removal by injecting nitrogen(N2) into an apparatus that generates nanobubbles using the friction tube method, in order to minimize the deaeration process and improve efficiency. The deaeration reaction time and economic feasibility of nanobubble generation using a friction tube were examined. Furthermore, this study verified the possibility of a downsized deaerator that can be easily converted into a mid- and large-sized device depending on the needs of research laboratories, cosmetics, personal care, and food industries, as well as specific company situations. Finally, the applicability of this deaerator in the chemical and construction sectors and facilities requiring industrial water, such as power plants and heating system pipelines was verified.
CAPM Model and Optimal Risky Portfolio for American Stock Market
Authors: Rong Runsheng 
Published: January 2024

Abstract
The stock market has high risks. The purpose of this project is to calculate the beta coefficients and build the optimal risky portfolio consisting of eight different stocks each representing different significant industries (which includes information technology, electric cars etc.) to diversify risk and gain a high return. Putting more stocks into the portfolio can help analysts carry out comprehensive analysis on different situations, periods, and types of investment portfolio, so as to disperse risks and obtain high returns, also, ensure the diversity of portfolio and a lower risk. The empirical results in this paper shows that by allocating their money appropriately in different stocks, investors can gain returns multiple times higher than putting all of them in merely one single stock, which proves the validity of this paper.
THE POTENTIAL EFFECT OF APORPHINE ALKALOIDS FROM NELUMBO NUCIFERA GAERTN. AS ANTI-BREAST CANCER BASED ON NETWORK PHARMACOLOGY AND MOLECULAR DOCKING
Authors: ADRIAN  , LUBIS MUHAMMAD FAUZAN , SYAHPUTRA RONY ABDI , ASTYKA RIRIN , SUMAIYAH SUMAIYAH , YUDHA HARAHAP MUHAMMAD ANDIKA , AINI ZAHRATUL 
Published: January 2024

Objective: To demonstrate the efficacy and benefits of aporphine alkaloids from Nelumbo nucifera Gaertn. as anti-breast cancer agents.
Methods: In this study, a combination of network pharmacology and molecular docking was used to investigate the pharmacological actions and underlying mechanisms of action of nuciferine, nor-nuciferine, and roemerine against breast cancer.
Results: Fifty-five potential targets of compounds against breast cancer were identified. The Epidermal Growth Factor Receptor (EGFR), Mitogen-Activated Protein Kinase 8 (MAPK8), Janus Kinase 2 (JAK2), Inhibitor of Nuclear Factor Kappa B Kinase Subunit Beta (IKBKB), and Protein Kinase C Epsilon (PRKCE) were identified as the top five targets of compounds against breast cancer. Molecular docking demonstrated that these compounds could bind spontaneously to the screened top 4 targeted proteins.
Conclusion: The present study demonstrates that these compounds have pharmacological effects against breast cancer via a multi-target and multi-pathway manner.
¿Sistema Bancario en las Sombras o Instituciones Financieras no Bancarias? Dos conceptos entre penumbras
Authors: Díaz Teresa 
Published: January 2024

Actualmente hay cierto consenso en que el colapso de Lehman Brothers fue provocado por una corrida en el Sistema Bancario en la Sombra en 2008 (Pozsar, et al., 2010; Gorton y Metrick, 2012; Vasudevan, 2018). La relevancia de este asentimiento se mantiene hasta nuestros días, no solamente se mantuvo después de la crisis, sino que ha crecido en virtud de la reivindicación que ha tenido dicho concepto mediante el discurso institucional renombrándolo como Instituciones Financieras No Bancarias, nombre que comúnmente se puede encontrar en la literatura económica, para dejar atrás algún vestigio peyorativo sobre este.
No obstante, el presente trabajo pretende hacer visible que no se trató de un simple cambio en la manera de referirse a éste, sino que tiene implicaciones más profundas. Bajo el discurso institucional internacional, pasó de ser nombrado Sistema Bancario en las Sombras, previo, durante e inmediatamente después del colapso de Lehman Brothers, para ser señalado como el culpable de la crisis, a las Instituciones Financieras No Bancarias. Quince años después, en virtud de se consideró como algo necesario para acceder al crédito, a los inversionistas no bancarios como una manera de obtener financiación barata para los bancos, lo que a su vez se traduce en crédito barato para los hogares. En consecuencia, hay incentivos para permitir que forme parte del ecosistema financiero.
Interpretation of Values in the Conceptual and Strategic Documents of the EAEU Countries: The Factor of Global Turbulence
Authors: Bakhlova O. V. , Bakhlov I. V. 
Published: January 2024

In a situation of growing international confrontation, it is important to clearly identify tools and mechanisms that can contribute to the consolidation of the positions of states friendly to Russia. In the context of one of the lines of global fragmentation — the division of the world into the West and non-West — the deepening and expansion of the Eurasian integration agenda is actualized.Aim. To determine the specifics of the interpretation of values in the conceptual and strategic documents of the EAEU countries in the context of their adaptation to the current challenges and threats of national and international security, integration dynamics and changes in the external environment in the conditions of global turbulence.Task. To characterize the axiological aspect of the existing conceptual and strategic documents of the EAEU countries; to identify key concepts that reveal the concept of values in them; to show common and distinctive features in the approaches of the EAEU countries in this area and the possibilities of their convergence at the integration level.Methods. The study was based on comparative analysis and non-formalized qualitative analysis of documents.Results. The main semantic blocks in the content of the conceptual and strategic documents of the EAEU countries are highlighted, taking into account the designated problem field. The focus of attention was on the interpretation of external challenges and threats, manifestations of global turbulence; articulation of certain values in a changing extern al environment; linking with the ethno-cultural component and identity issues. A significant coupling of approaches to the interpretation of values with the influence of external factors has been established. The specificity of verification of sources and directions of destructive influence is shown.Conclusions. The approaches of the EAEU countries to the interpretation of values in the perspective of events and processes taking place in the external dimension have a large number of coincidences and common features. The central concept in the studied documents is spiritual and moral values, the preservation and protection of which are embedded in the system of national interests / national strategic priorities. In the external dimension, international humanitarian cooperation is emphasized, which is conceived as a way of inter-civilizational dialogue against the background of increasing instability and conflict. A serious vulnerability can be considered the absence of an explicit interface between the value agenda formed by each of the countries of the Union and their integration guidelines and preferences.
“Crimean Issue” and the Civilizational Foundations of Russia’s Foreign Policy in the Context of a Global Hybrid War
Authors: Gapizov Z. R. , Kharitonova N. I. 
Published: January 2024

The article examines the role of the phenomenon of civilizational identity in Russia’s foreign policy in the context of the current hybrid confrontation based on the study of the parameters of the possibilities for resolving the “Crimean issue”. The essence of the global hybrid conflict between Russia and the West is analyzed, the possibilities of using the concept of civilizational identity as a geopolitical toolkit are determined. Aim . Unleashing the potential of the concept of civilizational identity in the global hybrid confrontation with the collective West in the context of the formation of a polycentric world order based on the experience of resolving the “Crimean issue”.Tasks. Determine the essence and parameters of the global geopolitical conflict in modern world political conditions; to characterize the role of the civilizational identity of the Crimean population in solving the “Crimean issue”, to identify the potential of civilizational identity for solving domestic and foreign political problems, taking into account Russian national interests.Methods. Geopolitical approach, system analysis, retrospective method, document analysis.Results . The study showed the need for the formation and conceptualization of the civilizational foundations of Russia’s foreign policy. This should be a larger-scale policy that is creative in nature and translates the principles of justice and peaceful interstate relations. Changes in Russian foreign policy thinking can bring positive results — to strengthen the Russian statehood, Russia’s international subjectivity, lay the foundations for a truly polycentric world order and expand the boundaries of the Russian world.Conclusions . The concept of civilizational identity acts as a universal an d effective tool for solving the “Crimean issue” and therefore should be considered both as a basic social value, and as a mandatory category of state document strategies, and as a formative element in th e information sphere.
Theoretical Aspects of the Formation of the Concept of Eurasian Security
Authors: Meleshin K. Yu. , Feonichev A. B. 
Published: January 2024

In the article, from the standpoint of the structural and functional approach, the theoretical aspects of the formation of the concept of security of the Eurasian space as a complex multilevel socio-cultural system are considered.Aim . To consider the essence of the security of the Eurasian space from the standpoint of a structural and functional approach.Tasks. To substantiate security as a function of the socio-cultural system, to consider the mechanisms of the impact of external and internal threats on Eurasian security.Methods. The structural and functional approach, system analysis, generalization, synthesis, comparative analysis were used.Results . The applied approach made it possible to formulate a definition of the security of a socio-cultural system, to identify ways to implement the security function by protecting and maintaining the system identity of its elements, as well as actively identifying destabilizing factors of the external and internal environment and countering them, in order to ensure effective, reliable and stable implementation of the purpose of the existence of a socio-cultural system.Conclusions . The analysis of the concept of “security” has shown that this concept is, first of all, a function of a socio-cultural system aimed at preventing or reducing damage from existing or potentially possible threats, allowing it to achieve the established goal of its existence. In this regard, within the framework of the Eurasian integration process, it is necessary to consider the security of the Greater Eurasia region not as a simple sum of the national security of the states that make up it, but as a basic function of a single complex Eurasian socio-cultural system, which is an independent center for the development of a multipolar world , ensuring the preservation of identity and development of the peoples of the historical Eurasian space, that is, as being on a more at a high system level, civilizational security.
Open Budget Effect on Corruption in the EAEU Countries
Authors: Bolgov R. V. 
Published: January 2024

Until 1991, the Eurasian Economic Union (EAEU) countries, namely Armenia, Belarus, Kazakhstan, Kyrgyzstan and Russia, were part of the unified budget system of the USSR. After the collapse of the Soviet Union and subsequent independence, the countries began to pursue an independent fiscal policy. In all five countries, a number of reforms have been implemented that have resulted in changes in the organization of fiscal policy, the creation of new fiscal institutions and the corresponding legal framework. Aim . To reveal the open budget effect on the corruption on the cases of the EAEU countries.Tasks. We analyze data from international organizations that assess the current situation in these countries.Methods. We assess the impact of open financial data (according to the Open Data Inventory, ODIN, prepared by Open Data Watch) on corruption for the five EAEU countries (2015–2020) based on unbalanced panel data analysis.Results . The hypothesis posed about the positive anti-corruption impact of an open budget in the EAEU countries was confirmed. We found that the quality of regulation and openness of the budget can affect the reduction of corruption.Conclusion. It is concluded that the EAEU countries differ significantly in anti-corruption and open budget policies and practices, as well as in the international organizations indices.
Risk factors for the alzheimer's disease. Systematic review and meta-analysis
Authors: Khasanova G. R. , Muzaffarova M. Sh. 
Published: January 2024

The “aging” of the population increased the importance of researches in the field of the epidemiology of chronic diseases, including Alzheimer's disease (AD) -the most common cause of dementia in the population.Aim. The role of potential risk factors for AD through a systematic review and meta-analysis. The “aging” of the population has updated research in the field of the epidemiology of chronic diseases, incl. Alzheimer's disease (AD) is the most common cause of dementia in the population. The aim of the study was to assess the role of potential risk factors for AD through a systematic review and meta-analysis.Materials and Methods. Using the electronic databases PubMed, Scopus, E-library, a search was made for articles in Russian and English, published from 1995 to 2022. In accordance with the clinical question, using the PECO formula, papers were selected in which the authors investigated the role of various risk factors in groups with and without AD. The study was carried out in accordance with the international guidelines for writing systematic reviews and meta-analyses "PRISMA". Study quality was analyzed using the Newcastle-Ottawa scale for cohort and case-control studies. The degree of heterogeneity was assessed using the chi-square test and the I2 coefficient. Publication bias was analyzed using a funnel plot. We used the software Review Manager 5.3 and Microsoft Office Excel 2010.Results. Initially, 3197 articles were retrieved from the databases; After screening and eligibility analysis, 17 studies were included in the me-ta-analysis (11 case-control studies and 6 cohort studies). Totally, these publications included data from 134,732 people with a confirmed diagnosis of AD and 1,058,143 respondents without AD (control group). According to the results of the meta-analysis, significant risk factors were: heredity (odds ratio (OR) 1.82; 95% confidence interval (95% CI) 1.66-1.99), arterial hypertension (OR 1.65; 95% CI 1.29-2.13), hypercholesterolemia (OR 1.25; 95% CI 1.13-1.38), obesity (OR 1.13; 95% CI 1.09-1.17), presence of diabetes mellitus 2 type (OR 1.36; 95%; CI 1.15-1.62), low level of education (OR 1.61; 95% CI 1.18-2.18), depression (OR 1.35; 95% CI 1.03-1.76). There was no relationship with alcohol consumption, smoking, a history of myocardial infarction and / or coronary heart disease, a history of acute cerebrovascular accident, insomnia, female gender, traumatic brain injury.Conclusion. The conducted meta-analysis allowed to obtain confirmation of the role of various potential risk factors for AD; at the same time, many of them are modifiable and are associated with metabolic disorders, which can probably be involved into the process of accumulation and deposition of beta-amyloid in the cells of the nervous system. Continued research on this issue could contribute to the development of prognostic scales and personalized recommendations for the prevention of this currently incurable disease.
Endometrial hyperplasia and endometrial polyps: clinical and anamnestic characteristics of women
Authors: Kravchenko E. N. , Lautenschleger E. V. 
Published: January 2024

Aim. To study the clinical and anamnestic characteristics of patients with endometrial hyperplasia (EH) and endometrial polyps (PE).Material and Methods. a retrospective study was conducted, which included 267 sick women of reproductive and perimenopausal age who sought gynecological care at «Euromed» in 2022-23, who, before receiving the examination results, were diagnosed with N92 - heavy, frequent and irregular menstruation. Depending on the results of the pathomorphological examination, the patients were divided into 3 groups: group A included 89 patients with GE; group B – 99 women with PE; Group B (control) included 79 patients in whom endometrial pathology was excluded.Results. Among all women who came to the clinic with heavy menstrual bleeding, 33.3% had GE, 37.1% had PE, 29.6% had BUN-O ovulatory dysfunction. GE without atypia was detected in 72 (80.9%) cases of group A, GE with atypia – in 7 (19.1%), in group B PE was diagnosed in 91 (91.9%) cases, PE with atypia – in 28 (8.1%).In group B, in 22 (27.8%) cases, the endometrium was identified in the proliferation phase, in 57 (72.2%) cases, the endometrium was identified in the phase of incomplete secretion.Conclusion. Women with GE are characterized by early menarche, absence of pregnancies and childbirth during life associated with the woman’s choice, contraception, endocrine diseases, obesity, polycystic ovary syndrome, ovarian tumors, heavy bleeding with clots during menstruation, menstruation for more than 8 days, chronic iron deficiency anemia. Women with endometrial polyps are characterized by arterial hypertension, uterine fibroids, adenomyosis, infertility, dysmenorrhea, chronic endometritis, a history of cervicitis and vaginitis; clinical manifestations include intermenstrual bleeding.
Biocompatibility and features of degradation of polymer anti-adjection membranes with antibacterial activity
Authors: Kudryavtseva Yu. A. , Kanonykina A. Yu. , Efremova N. A. , Koshelev V. A. 
Published: January 2024

When performing operations on the abdominal and thoracic organs, the main share of postoperative complications is represented by the formation of adhesions or the development of an infectious process, which leads to a decrease in the quality of life of patients, the need for reoperation and often causes deaths. A solution to this problem can be the use of intraoperative biodegradable anti-adhesion membranes that have their own antibacterial activity.Aim. Development of polymer anti-adhesion membranes with their own anti-inflammatory and antibacterial activity, assessment of their biocompatibility and biodegradation in in vivo experimentsMaterials and Methods. The membranes are made by electrospinning from a composition of biodegradable polymers: polylactide-co-glycolide copolymer (50:50) and polylactide-co-glycolide (85:15). To impart antibacterial properties to the membrane, the antibiotic Tigacil was added to the polymer solution in various dosages - 0.125; 0.25 and 0.5 mg/ml polymer solution. The antibacterial activity of the membranes in vivo was assessed. The physical and mechanical properties were studied and the surface structure of the membranes was assessed using a scanning electron microscope. Biocompatibility and dynamics of biodegradation were assessed in vivo by implantation into laboratory animals (rats) for periods of 14 days, 1, 2 and 3 months, followed by histological examination of explanted samples.Results. Polymer membranes made by electrospinning, without the inclusion of Tigacil, consist of threads whose thickness was 1.63 microns (1.422.85 microns); when Tigacil is included in the fiber composition, the fiber thickness decreases to 1.2 microns (0.977 - 1.89 pm), while the threads are more densely and orderly located. The strength and elasticity modulus of membranes with Tigacil are almost 2 times higher than those of samples without the inclusion of the drug. The maximum antibacterial effect was achieved at a Tigacil dosage of 0.5 mg/ml - the zone of inhibition of Staphylococcus aureus at a Tigacil concentration of 0.125 mg/ ml was 146%, 0.25 mg/ml - 152% and at a concentration of 0.5 mg/ml - 11 .5 mm 177%. The inclusion of Tigacil led to a decrease in the rate of biodegradation of samples in vivo. The samples underwent biodegradation without signs of acute and chronic inflammation.Conclusion. The inclusion of Tigacil in the membrane gives it antibacterial properties, and the optimal concentration of Tigacil was 0.5 mg/ml of the polymer solution. The inclusion of Tigacil in the polymer composition affects the morphology of the membranes, increases the strength and elastic modulus, which led to a decrease in the rate of degradation when implanted subcutaneously in rats. The absence of signs of inflammation confirms the biocompatibility of the developed membranes.
Psychometric properties of the Mexican version of the Intolerance of Uncertainty Scale: The IUS-12M
Authors: Hernández-Posadas Alejandrina , De la Rosa-Gómez Anabel , Lommen Miriam J. J. , Bouman Theo K. , Mancilla-Díaz Juan M. , Del Palacio González Adriana 
Published: January 2024

Background: The Intolerance of Uncertainty Scale short version (IUS-12) has proven to be a robust self-report measure to assess intolerance of uncertainty. While previous psychometric analyses of the IUS-12 have established a stable two-factor structure corresponding to the prospective and inhibitory factors of intolerance of uncertainty, recent studies suggest that the bifactor model may better explain its factor structure. Objective: The current study aimed to adapt and validate the IUS-12 in a Mexican population culturally. Method: The study consisted of a convenience non-probabilistic community sample of 405 adults between 18 and 70 years. Results: Confirmatory factor analyses supported a bifactor model and good internal consistency. Invariance testing indicated partial invariance across women and men. Convergent validity tests showed that the IUS-12 was related to measures of worry, as well as depression and anxiety. Conclusion: These findings provide evidence for the reliability and validity of the adapted version of the IUS-12 in Mexico.