bluuebunny/crossref_metadata_2025_split huggingface dataset:
Long noncoding RNAs in human reproductive processes and diseases
Authors: Zhang Le , Sun Hailong , Chen Xiujuan 
Published: January 2024

AbstractInfertility has become a global disease burden. Although assisted reproductive technologies are widely used, the assisted reproduction birth rate is no more than 30% worldwide. Therefore, understanding the mechanisms of reproduction can provide new strategies to improve live birth rates and clinical outcomes of enhanced implantation. Long noncoding RNAs (lncRNAs) have been reported to exert regulatory roles in various biological processes and diseases in many species. In this review, we especially focus on the role of lncRNAs in human reproduction. We summarize the function and mechanisms of lncRNAs in processes vital to reproduction, such as spermatogenesis and maturation, sperm motility and morphology, follicle development and maturation, embryo development and implantation. Then, we highlight the importance and diverse potential of lncRNAs as good diagnostic molecular biomarkers and therapeutic targets for infertility treatment.
A partial epithelial‐mesenchymal transition signature for highly aggressive colorectal cancer cells that survive under nutrient restriction
Authors: Pastorino Gil A , Sheraj Ilir , Huebner Kerstin , Ferrero Giulio , Kunze Philipp , Hartmann Arndt , Hampel Chuanpit , Husnugil Hepsen Hazal , Maiuthed Arnatchai , Gebhart Florian , Schlattmann Fynn , Gulec Taskiran Aliye Ezgi , Oral Goksu , Palmisano Ralph , Pardini Barbara , Naccarati Alessio , Erlenbach‐Wuensch Katharina , Banerjee Sreeparna , Schneider‐Stock Regine 
Published: January 2024

AbstractPartial epithelial‐mesenchymal transition (p‐EMT) has recently been identified as a hybrid state consisting of cells with both epithelial and mesenchymal characteristics and is associated with the migration, metastasis, and chemoresistance of cancer cells. Here, we describe the induction of p‐EMT in starved colorectal cancer (CRC) cells and identify a p‐EMT gene signature that can predict prognosis. Functional characterisation of starvation‐induced p‐EMT in HCT116, DLD1, and HT29 cells showed changes in proliferation, morphology, and drug sensitivity, supported by in vivo studies using the chorioallantoic membrane model. An EMT‐specific quantitative polymerase chain reaction (qPCR) array was used to screen for deregulated genes, leading to the establishment of an in silico gene signature that was correlated with poor disease‐free survival in CRC patients along with the CRC consensus molecular subtype CMS4. Among the significantly deregulated p‐EMT genes, a triple‐gene signature consisting of SERPINE1, SOX10, and epidermal growth factor receptor (EGFR) was identified. Starvation‐induced p‐EMT was characterised by increased migratory potential and chemoresistance, as well as E‐cadherin processing and internalisation. Both gene signature and E‐cadherin alterations could be reversed by the proteasomal inhibitor MG132. Spatially resolving EGFR expression with high‐resolution immunofluorescence imaging identified a proliferation stop in starved CRC cells caused by EGFR internalisation. In conclusion, we have gained insight into a previously undiscovered EMT mechanism that may become relevant when tumour cells are under nutrient stress, as seen in early stages of metastasis. Targeting this process of tumour cell dissemination might help to prevent EMT and overcome drug resistance. © 2024 The Authors. The Journal of Pathology published by John Wiley & Sons Ltd on behalf of The Pathological Society of Great Britain and Ireland.
Effect of silane coupling grafted polyethylene terephthalate foam and areca fruit fiber reinforced chitin modified vinyl ester prosthetic composite on thermal and water accelerated aging conditions
Authors: Khan Mohammad K. A. , Faisal M. , Arun Prakash V. R. 
Published: January 2024

AbstractThe primary aim of this research work was to develop a lightweight vinyl ester based prosthetic composite with silane treated Polyethylene terephthalate (PET) foam and areca fiber and how the silane surface treatment process influence the laminar adhesion against to accelerated aging conditions. Both the foam (3 mm) and fiber is silane‐treated via aqueous solution method and the composites were subjected to accelerate aging via temperature (40 and 50°C) as well as sea and rain water. The developed composites were evaluated based on American society of testing of materials (ASTM) standards and the results revealed a consistent stability in tensile strength for post‐silane treated composites on both aging conditions. Particularly, the interlaminar shear strength (ILSS) test emphasized that the silane treated reinforcements has high resistance against delamination. Similarly, flammability test demonstrated sustained fire‐resistant properties in both horizontal and vertical orientations, with negligible variations in flame propagation speed. Thermal conductivity test revealed the intricate interplay of PET core and areca fiber on heat transfer. Thus, from results it is evident that the silane surface treatment helped to maintain the laminates adhere with matrix in spite of the accelerated aging conditions such as prolonged heat exposition as well as water immersion. These findings contribute valuable insights into the load bearing performance of the lightweight composite materials in human prosthetic applications where prolonged heat and water aging happened frequently.Highlights
Lightweight polymer foam‐areca fiber prosthetic composites prepared and tested for accelerated weather conditions
PET foam and areca fiber is silane surface treated using amino‐silane
Treated foam and fiber maintained mechanical properties under aged condition
Treated foam and fiber maintained flammability properties under aged condition
Silane treated foam and fiber maintained good thermal conductivity under aged condition
Iodine and DMSO as Surrogate of Hazardous Metal and Non‐Metal Reagents in Organic Synthesis
Authors: Reetu Reetu , Kalita Sangita , Dash Sonali , Malakar Chandi C. 
Published: January 2024

AbstractOrganic synthesis involves the production of important chemical structures using scalable and cost‐effective methods that are also environmentally friendly. In this review, a detailed analysis of the use of iodine and DMSO in various synthetic routes for the preparation of valuable targets are presented. These methods reduce the acceptance on expensive additives and reagents, and offer a more sustainable solution for the synthesis of these important chemical scaffolds.
Analysis of SQL injection attacks in the cloud and in WEB applications
Authors: Kumar Animesh , Dutta Sandip , Pranav Prashant 
Published: January 2024

AbstractCloud computing has revolutionized the way IT industries work. Most modern‐day companies rely on cloud services to accomplish their day‐to‐day tasks. From hosting websites to developing platforms and storing resources, cloud computing has tremendous use in the modern information technology industry. Although an emerging technique, it has many security challenges. In structured query language injection attacks, the attacker modifies some parts of the user query to still sensitive user information. This type of attack is challenging to detect and prevent. In this article, we have reviewed 65 research articles that address the issue of its prevention and detection in cloud and Traditional Networks, of which 11 research articles are related to general cloud attacks, and the rest of the 54 research articles are specifically on web security. Our result shows that Random Forest has an accuracy of 99.8% and a Precision rate of 99.9%, and the worst‐performing model is Multi‐Layer Perceptron (MLP) in the SQLIA Model. For recall value, Random Forest performs best while TensorFlow Linear Classifier performs worst. F1 score is best in Random Forest, while MLP is the most diminutive performer.
Genome‐wide development of intra‐ and inter‐specific transferable SSR markers and construction of a dynamic web resource for yam molecular breeding: Y2MD
Authors: Diouf Moussa , Zoclanclounon Yedomon Ange Bovys , Mboup Pape Adama , Diouf Diaga , Malédon Erick , Rivallan Ronan , Chair Hâna , Dossa Komivi 
Published: January 2024

AbstractMicrosatellite markers are widely used in population genetics and breeding. Despite the economic significance of yams in developing countries, there is a paucity of microsatellite markers, and as of now, no comprehensive microsatellite marker database exists. In this study, we conducted genome‐wide microsatellite marker development across four yam species, identified cross‐species transferable markers, and designed an easy‐to‐use web portal for the yam researchers. The screening of Dioscorea alata, Dioscorea rotundata, Dioscorea dumetorum, and Dioscorea zingiberensis genomes resulted in 318,713, 322,501, 307,040, and 253,856 microsatellites, respectively. Mono‐, di‐, and tri‐nucleotides were the most important types of repeats in the different species, and a total of 864,128 primer pairs were designed. Furthermore, we identified 1170 cross‐species transferable microsatellite markers. Among them, 17 out of 18 randomly selected were experimentally validated with good discriminatory power, regardless of the species and ploidy levels. Ultimately, we created and deployed a dynamic Yam Microsatellite Markers Database (Y2MD) available at https://y2md.ucad.sn/. Y2MD is embedded with various useful tools such as JBrowse, Blast, insilicoPCR, and SSR Finder to facilitate the exploitation of microsatellite markers in yams. This study represents the first comprehensive microsatellite marker mining across several yam species and will contribute to advancing yam genetic research and marker‐assisted breeding. The released user‐friendly database constitutes a valuable platform for yam researchers.
Incidence, characteristics, and predictive factors of post‐colonoscopy colorectal cancer
Authors: Baile‐Maxía Sandra , Mangas‐Sanjuan Carolina , Sala‐Miquel Noelia , Barquero Claudia , Belda Germán , García‐del‐Castillo Gloria , García‐Herola Antonio , Penalva Juan Carlos , Picó María‐Dolores , Poveda María‐José , de‐Vera Félix , Zapater Pedro , Jover Rodrigo 
Published: January 2024

AbstractBackgroundPost‐colonoscopy colorectal cancer (PCCRC) is colorectal cancer (CRC) diagnosed after a colonoscopy in which no cancer is found.ObjectiveAs PCCRC has become an important quality indicator, we determined its rates, characteristics, and index colonoscopy‐related predictive factors.MethodsWe carried out a multicenter, observational, retrospective study between 2015 and 2018. Rates were calculated for PCCRC developing up to 10 years after colonoscopy. PCCRC was categorized according to the most plausible explanation using World Endoscopy Organization methodology. Our PCCRC population was compared to a control cohort without CRC matched 1:4 by sex, age, index colonoscopy date, indication, endoscopist, and hospital.ResultsOne hundred seven PCCRC and 2508 detected CRC were diagnosed among 101,524 colonoscopy (0.1%), leading to rates of 0.4%, 2.2%, 3.1%, and 4.1% at 1, 3, 5, and 10 years, respectively. PCCRC was in right (42.4%), left (41.4%), and transverse (16.4%) colon with 31.5% at stage I, 24.7% stage II, 32.6% stage III, and 11.2% stage IV. Twenty point three percent were classified as incomplete resection, 5.4% as unresected lesions, 48.6% as missed lesions with adequate colonoscopy, and 25.7% as missed lesions with inadequate colonoscopy. The median time from colonoscopy to PCCRC was 42 months. Previous inadequate preparation (OR 3.05, 95%CI 1.73–5.36) and piecemeal polypectomy (OR 19.89, 95%CI 8.67–45.61) were independently associated with PCCRC.ConclusionsIn our population, 4.1% of CRC cases were PCCRC. Most of these lesions were in right colon and attributable to lesions not visualized despite adequate bowel cleansing. Previous inadequate cleansing and piecemeal polypectomy were associated with PCCRC.
Aiming for tops of ALPs with a muon collider
Authors: Chigusa So , Girmohanta Sudhakantha , Nakai Yuichiro , Zhang Yufei 
Published: January 2024

Abstract
Future muon colliders with center-of-mass energy of $$ \mathcal{O} $$
O
(1 − 10) TeV can provide a clean high-energy environment with advantages in searches for TeV-scale axion-like particles (ALPs), pseudo-Nambu-Goldstone bosons associated with spontaneously broken global symmetries, which are widely predicted in physics beyond the Standard Model (SM). We exploit ALP couplings to SM fermions, and guided by unitarity constraints, build a search strategy focusing on the ALP decay to top quark pairs at muon colliders. It is found that a large parameter space of TeV-scale ALPs with TeV-scale decay constants can be probed by utilizing the ALP-top quark coupling.
Global analysis of the ALP effective theory
Authors: Bruggisser Sebastian , Grabitz Lara , Westhoff Susanne 
Published: January 2024

Abstract
We perform a global fit of the effective Lagrangian for axion-like particles (ALPs) to data. By combining LHC observables from top physics, dijet and di-boson production with electroweak precision observables, we resolve the full parameter space of ALPs with flavor-universal couplings. Using the renormalization group to evolve the effective ALP couplings to low energies allows us to investigate the impact of flavor observables on the global analysis. We show that resonance searches in B → K meson decays significantly enhance the sensitivity to ALPs with sub-GeV masses. The lifetime of the ALP plays a crucial role in resolving the multi-dimensional parameter space with searches for prompt, displaced and invisible ALP decays. Our analysis points out the differences in probing an effective theory with new light particles, compared to scenarios with only non-resonant effects of heavy particles at low energies, as in the Standard Model Effective Field Theory.
The O(N) monolith reloaded: sum rules and Form Factor Bootstrap
Authors: Córdova Lucía , Correia Miguel , Georgoudis Alessandro , Vuignier Antoine 
Published: January 2024

Abstract
We revisit the space of gapped quantum field theories with a global O(N) symmetry in two spacetime dimensions. Previous works using S-matrix bootstrap revealed a rich space in which integrable theories such as the non-linear sigma model appear at special points on the boundary, along with an abundance of unknown models hinting at a non conventional UV behaviour. We extend the S-matrix set-up by including into the bootstrap form factors and spectral functions for the stress-energy tensor and conserved O(N) currents. Sum rules allow us to put bounds on the central charges of the conformal field theory (CFT) in the UV. We find that a big portion of the boundary can only flow from CFTs with infinite central charges. We track this result down to a particular behaviour of the amplitudes in physical kinematics and discuss its physical implications.
Operator dynamics in Lindbladian SYK: a Krylov complexity perspective
Authors: Bhattacharjee Budhaditya , Nandy Pratik , Pathak Tanay 
Published: January 2024

Abstract
We use Krylov complexity to study operator growth in the q-body dissipative Sachdev-Ye-Kitaev (SYK) model, where the dissipation is modeled by linear and random p-body Lindblad operators. In the large q limit, we analytically establish the linear growth of two sets of coefficients for any generic jump operators. We numerically verify this by implementing the bi-Lanczos algorithm, which transforms the Lindbladian into a pure tridiagonal form. We find that the Krylov complexity saturates inversely with the dissipation strength, while the dissipative timescale grows logarithmically. This is akin to the behavior of other 𝔮-complexity measures, namely out-of-time-order correlator (OTOC) and operator size, which we also demonstrate. We connect these observations to continuous quantum measurement processes. We further investigate the pole structure of a generic auto-correlation and the high-frequency behavior of the spectral function in the presence of dissipation, thereby revealing a general principle for operator growth in dissipative quantum chaotic systems.
Equivariant volume extremization and holography
Authors: Colombo Edoardo , Faedo Federico , Martelli Dario , Zaffaroni Alberto 
Published: January 2024

Abstract
In a previous paper two of us (D.M. and A.Z.) proposed that a vast class of gravitational extremization problems in holography can be formulated in terms of the equivariant volume of the internal geometry, or of the cone over it. We substantiate this claim by analysing supergravity solutions corresponding to branes partially or totally wrapped on a four-dimensional orbifold, both in M-theory as well as in type II supergravities. We show that our approach recovers the relevant gravitational central charges/free energies of several known supergravity solutions and can be used to compute these also for solutions that are not known explicitly. Moreover, we demonstrate the validity of previously conjectured gravitational block formulas for M5 and D4 branes. In the case of M5 branes we make contact with a recent approach based on localization of equivariant forms, constructed with Killing spinor bilinears.
Partial spectral flow in the D1D5 CFT
Authors: Guo Bin , Hampton Shaun 
Published: January 2024

Abstract
The two-dimensional 𝒩 = 4 superconformal algebra has a free field realization with four bosons and four fermions. There is an automorphism of the algebra called spectral flow. Under spectral flow, the four fermions are transformed together. In this paper, we study partial spectral flow where only two of the four fermions are transformed. Partial spectral flow is applied to the D1D5 CFT where a marginal deformation moves the CFT away from the free point. The partial spectral flow is broken by the deformation. We show that this effect can be studied due to a transformation of the deformation which is well-defined under partial spectral flow. As a result in the spectrum, we demonstrate how to compute the second-order energy lift of a D1D5P state through its partial spectral flowed state. We find that D1D5P states related by partial spectral flow do not have the same lift in general.
cntTSP visualization technique for rotating blade surface flow at low Reynolds number
Authors: Ikami Tsubasa , Nishimura Ren , Nagai Hiroki 
Published: January 2024

AbstractResearch and development of aircraft with rotating wings at low Reynolds numbers have received much attention. This study proposes using a carbon nanotube temperature-sensitive paint (cntTSP) measurement technique to visualize the surface flow of rotor blades at low Reynolds numbers. Temperature-sensitive paint (TSP) can optically measure a two-dimensional temperature field using the thermal quenching of luminophores. A carbon nanotube thin layer is used to heat the TSP layer in cntTSP measurements. For the experimental condition, the low Reynolds number at 75% of the rotor radius was 1.1 × 104, and a blade tip speed of 7.2 m/s. Temperature distributions showing a leading edge vortex (LEV) were observed in the visualization results. Furthermore, the LEV region expanded from the wing-tip side to the wing-root side at high-pitch angles. These visualization results show the applicability of the cntTSP measurement technique for investigating the surface flow field of rotor blades at low Reynolds numbers.
Graphical abstract
Amygdala structure and function and its associations with social-emotional outcomes in a low-risk preterm sample
Authors: Fernández de Gamarra-Oca L. , Lucas-Jiménez O. , Ontañón J. M. , Loureiro-Gonzalez B. , Peña J. , Ibarretxe-Bilbao N. , García-Guerrero M. A. , Ojeda N. , Zubiaurre-Elorza L. 
Published: January 2024

AbstractAmygdala atypical volume development and functional connectivity (FC) at small gestational ages (GA) have been found across childhood. This adult-oriented study assesses whether altered amygdala structure and function is present following low-risk preterm birth. T1-weighted and resting-state functional MRI images of 33 low-risk preterm (30–36 weeks’ GA) and 29 full-term (37–42 weeks’ GA) young adults of both sexes, aged between 20 and 32 years old, were analyzed using FreeSurfer (v6.0.0) and Coon Toolbox (v21.a). The social-emotional assessment included Happé’s Strange Stories Test, the Moral Judgment Test, Delay-Discounting Test, Adult Self Report, and Emotion Regulation Questionnaire. No differences were found in social-emotional outcomes or amygdala volumes between the groups. Low-risk preterm young adults showed increased FC between the left amygdala, right amygdala and medial frontal cortex (MedFC) (F = 9.89, p-FWE = 0.009) at cluster level compared to their full-term peers. However, significant results at connection level were not observed between left and right amygdala. Lastly, increased FC at cluster level between the right amygdala and MedFC, and left amygdala and MedFC, was related to better social-emotional outcomes only in low-risk preterm young adults (F = 6.60, p-FWE = 0.036) at cluster level. At connection level, in contrast, only right amygdala–MedFC increased FC was significantly associated with better social-emotional outcomes. This study reveals that low-risk prematurity does not have an effect on social-emotional outcomes or structural amygdala volumes during young adulthood. However, individuals who were considered to be at a lower risk of exhibiting neurodevelopmental alterations following preterm birth demonstrated increased FC between the left and right amygdala and MedFC.
Mitophagy plays a “double-edged sword” role in the radiosensitivity of cancer cells
Authors: Wang Qian , Liu Chengxin 
Published: January 2024

AbstractMitochondria are organelles with double-membrane structure of inner and outer membrane, which provides main energy support for cell growth and metabolism. Reactive oxygen species (ROS) mainly comes from mitochondrial and can cause irreversible damage to cells under oxidative stress. Thus, mitochondrial homeostasis is the basis for maintaining the normal physiological function of cells and mitophagy plays a pivotal role in the maintenance of mitochondrial homeostasis. At present, to enhance the sensitivity of cancer cells to radiotherapy and chemotherapy by regulating mitochondria has increasingly become a hot spot of cancer therapy. It is particularly important to study the effect of ionizing radiation (IR) on mitochondria and the role of mitophagy in the radiosensitivity of cancer cells. Most of the existing reviews have focused on mitophagy-related molecules or pathways and the impact of mitophagy on diseases. In this review, we mainly focus on discussing the relationship between mitophagy and radiosensitivity of cancer cells around mitochondria and IR.