bluuebunny/crossref_metadata_2025_split huggingface dataset:
Network Pharmacological Analysis and Experimental Validation of Anti-lung Cancer Effect of Echinacea Purpurea
Authors: Ma Shengming , Mao Chiwen , Weng Shaoting , Jiang Zhihui , Hao Jie , Zhang Kunpeng 
Published: January 2025

Background:
Echinacea purpurea is a medicinal plant recognized for its rich array of
bioactive constituents, making it a valuable resource for drug development. However, the potential
antitumor effects and underlying mechanisms of Echinacea remain largely unexplored.

Methods:
This study aims to elucidate the active ingredients, targets, and pathways mediating the
anti-lung cancer effects of Echinacea through the lens of network pharmacology and to further validate
the efficacy of the extract of Echinacea purpurea against lung cancer in vitro.

Results:
An 'Echinacea-lung cancer-target' network was constructed using network pharmacology,
identifying quercetin, β-sitosterol, rutin, dibutyl phthalate, ferulic acid, and protocatechuic acid as the
primary active components contributing to Echinacea's anti-lung cancer activity. These components
may exert antitumor effects by modulating key targets, including TP53, AKT1, HSP90AA1, JUN,
and IL6, through the PI3K-Akt, MAPK, IL-17, HIF-1, and TNF signaling pathways. Subsequently,
MEPT was administered to human lung cancer PC-9 cells, revealing that the Echinacea extract inhibited
cell proliferation, migration, and the expression of cell cycle proteins in a concentration- and
time-dependent manner while also inducing early apoptosis in tumor cells.

Conclusion:
These findings suggest that the anti-lung cancer activity of Echinacea operates through
a synergistic mechanism involving multiple components, targets, and pathways, potentially leading
to cell cycle arrest and the induction of apoptosis.
Integrating Machine Learning and Pharmacophore Features for Enhanced Prediction of H1 Receptor Blockers
Authors: Sherwani Zaid Anis , Nur-e-Alam Mohammad , Ahmed Aftab , Ul-Haq Zaheer 
Published: January 2025

Introduction:
Histamine Type I Receptor Antagonists (H1 blockers) are widely used to
mitigate histamine-induced inflammation, particularly in allergic reactions. Histamine, a biogenic
amine found in endothelial cells, vascular smooth muscle, bronchial smooth muscle, and the hypothalamus,
is a key player in these responses. H1 blockers are essential in cough syrups and flu medications
and are divided into two generations: first-generation H1 blockers, which are sedating and
have numerous side effects, and second-generation blockers, which are non-sedating and generally
less toxic but may still exhibit cross-reactivity with other receptors.

Method:
In this study, a comprehensive database of compounds was utilized alongside fexofenadine
as a benchmark to discover compounds with potentially superior efficacy and reduced side
effect profiles. In particular, multidimensional K-means clustering, a machine-learning technique,
was applied to identify compounds with chemical structures similar to fexofenadine.

Result:
Utilizing computational prediction of pharmacokinetic profile and molecular docking experiments,
the action of these drugs on the H1 receptor was assessed. Furthermore, the crossreactivity
of antihistamines was investigated by conducting a structure-based pharmacophore feature
analysis of the docked poses of highly toxic antihistamines with various receptors.

Conclusion:
By identifying and proposing the removal of common toxic features, we aim to facilitate
the development of antihistamines with fewer adverse effects.
A Clinical Multicenter Trial of Recombinant Human Interferon Gamma in Tuberculosis (GAM2022) Experience with the Use of Human Recombinant Interferon Gamma in TB Practice
Authors: Izosimova Veronika E. , Barmina Natal'ja A. , Zharikova Marija P. , Alekseyev Oleg Ye. , Ryzhkova Oxana A. , Sayfulin Marat H. , Popova Natal'ja A. , Andreyev Mihail A. , Gagarina Svetlana G. , Rysdauletova Raisa M. , Kamaeva Natal'ja G. , Samoylova Anastasiya G. , Romanova Marija I. 
Published: January 2025

Background:
In this article, we present the results of a multicenter clinical trial of IFN-γ in patients with drug-susceptible and drug-resistant pulmonary Tuberculosis (TB) in routine clinical practice.

Objective:
This study aimed to confirm the efficacy and safety of IFN-γ administered to patients with TB.

Methods:
All patients were diagnosed with TB after being tested by bacterioscopic and molecular genetic methods and had no contraindications to standard chemotherapy.

Results:
Recombinant human IFN-γ proved high efficacy in multi-center clinical trials in routine TB practice.

Conclusion:
The results show that IFN-γ is efficient and safe in the treatment of pulmonary tuberculosis.
Exploring Moisture Content in 50 Rough Rice through Micro Oven for Deeper Dietary Insights
Authors: Saha Sneha , chowdhury Prasun Roy , Chatterjee Moumita , Hushneara Syed , Lahiri Shibani 
Published: January 2025

Introduction/Objective:
Rice, an ancient cereal grain and a dietary staple in India is globally cherished for its affordability, accessibility, and nutritional richness. It is a rich source of energy, containing essential nutrients such as carbohydrates, calcium, iron, and more. How-ever, its moisture content significantly influences quality, taste, and safety, affecting shelf life and susceptibility to spoilage and microbial growth. Improper storage practices lead to substan-tial losses of milled rice worldwide.

Methods:
To address this issue, a study was conducted on 50 raw rice (uncooked) samples from India to determine their moisture levels using a microwave method with a 900W power output for specific durations.

Results:
The results revealed an overall moisture content of 7.12±1.87 %, ranging from 3.73 % to 28.49 %. Significant differences were observed across locations rice varieties, and size with long-grain rice ranging from 4.90% to 11.02%, medium-grain from 3.73 % to 8.63 %., and short-grain from 4.17 % to 28.49 %. Long-grain had the highest average moisture content of 7.21±1.85 %, followed by short-grain rice at 7.8±1.84 %, and medium-grain at 6.03±1.44 %. Attap Rice stood out with higher moisture levels, highlighting the importance of careful storage practices. Parboiled rice tends to have higher moisture content than milled rice. Therefore, stor-ing rice properly is crucial in terms of security for public health.

method:
To address this issue, a study was conducted on 50 raw rice (uncooked) samples from India to determine their moisture levels using a microwave method with a 900W power output for specific durations.

Conclusion:
Moisture data aid in optimizing harvesting, and drying practices, adjusting milling and packaging techniques, and calculating rice's nutritional intake accurately; and economically disadvantaged individuals should opt for rice with lower moisture content for higher carbohy-drate content per unit. By employing these data for various rice types, food manufacturers can implement tailored storage conditions and processing techniques to ensure optimal product safety and consistency.

result:
The results revealed an overall moisture content of 7.12±1.87 %, ranging from 3.73 % to 28.49 %. Significant differences were observed across locations and rice varieties, and size with long-grain rice ranging from 4.90% to 11.02%, medium-grain from 3.73 % to 8.63 %., and short-grain from 4.17 % to 28.49 %. Long-grain had highest average moisture content of 7.21±1.85 %, followed by short-grain rice of 7.8±1.84 %, and medium-grain of 6.03±1.44 %. Attap Rice stood out with higher moisture levels, highlighting the importance of careful storage practices. Parboiled rice tends to have higher moisture content than milled rice. Therefore, storing rice properly is crucial in terms of secure to public health.

other:
NA
Effect of Race on Transplantation in Autosomal Dominant Polycystic Kidney Disease
Authors: Krishnamoorthy Sambhavi , Satishchandra Niveditha Girimaji , Chapman Arlene , McGill Rita 
Published: January 2025

Key Points

Despite overall superior outcomes, transplant outcomes of patients with autosomal dominant polycystic kidney disease are heavily influenced by race.Access to living donor and preemptive transplantation partly explains these racial disparities.Favorable Expected Post-Transplant Survival scores suggest that promoting equity would result in improved survival for patients with ADPKD.

Background
Autosomal dominant polycystic kidney disease (ADPKD) is the most common genetic cause of ESKD and occurs without racial predilection. In general, non-White patients with ESKD have less access to transplantation, especially living donor transplantation. We examined long-term outcomes of patients with ADPKD-ESKD by self-reported race, with attention to the trajectory of Estimated Post-Transplant Survival (EPTS) scores over time.

Methods
United Network for Organ Sharing Standard Transplant Analysis and Research files were used to identify 32,611 ADPKD transplant recipients between January 2000 and December 2022. EPTS scores were calculated from the date of waitlisting until transplantation occurred. Cumulative incidences of living and deceased transplantation were calculated and plotted. Cox models were made for graft failure and death, and a subdistribution hazards model for graft failure accounted for death as a competing outcome, with adjustment for patient, donor, and transplant factors.

Results
Compared with White patients with ADPKD, all other groups had more dialysis years, more delayed graft function, and fewer living and preemptive transplants; mean EPTS scores were lower in Black and Hispanic patients at each time point on the waitlist. However, EPTS scores at the time of transplant was less likely to be <20% in Black and Hispanic patients because of longer waiting time. Black patients had a significantly higher risk of graft failure with death as competing risk compared with White patients. Asian and Hispanic patients had similar graft survivals but better patient survival compared with White patients.

Conclusions
Waitlist experience, allograft quality, and post-transplant outcomes of patients with ADPKD are influenced by patient race.
Increasing incidences and changes in treatment trends of clavicle fractures in adults during 2 decades in Denmark: a nationwide study on data from the Danish National Patient Registry
Authors: Tryggedsson Ida , Viberg Bjarke , Gundtoft Per Hviid , Ban Ilija , Overgaard Søren , Maleitzke Tazio , Von Keudell Arvind 
Published: January 2025

Background and purpose: Clavicle fractures are common shoulder injuries, but treatment strategies are debated. While a non-surgical approach has been preferred historically, recent studies suggest surgical intervention may reduce non-union rates and improve outcomes for displaced fractures. Despite ongoing research there is still no consensus on the optimal treatment choice. We aimed to report national incidences and trends in treatment of clavicle fractures in Denmark across 2 decades.Methods: The Danish National Patient Register was used to extract data on clavicle fracture diagnosis and treatment in patients aged 18 and above from 1996 to 2018. Primary treatment was categorized as surgical if a relevant surgical procedure code was registered within 3 weeks of the fracture code, otherwise treatment was defined as non-surgical.Results: There were 81,597 clavicle fractures recorded; 67% were in men and the mean age was 50.3 years (standard deviation [SD] 19.5). The overall fracture incidence was 82/100,000/person-years, increasing by 11% from 76 in 1996 to 84 in 2018. The incidence was more than 50% higher in males (113) than females (53). 6,096 cases (7.5%) were treated surgically, mainly with plate osteosynthesis (94%). The surgical rate increased from 1% in 1996 to 14% in 2011, whereafter it decreased again. In 2018, 7% of clavicle fractures were treated surgically, with inter-hospital variations ranging from 0 to 15%.Conclusion: The incidence of clavicle fractures increased over the period. Non-surgical treatment remained prevalent, though surgical rates fluctuated with plate osteosynthesis being the preferred method.
The first record of non-indigenous cicada Graptopsaltria nigrofuscata (Motschulsky, 1866) (Hemiptera: Cicadidae, Polyneurini) in Slovakia
Authors: Kollár Ján , Janský Vladimír , Donoval Ľuboš 
Published: January 2025

Abstract
This paper provides the first record of the large brown cicada Graptopsaltria nigrofuscata (Motschulsky, 1866) in Slovakia. This cicada species is native to Japan, Korea and China. An adult and several exuviae were found near the city of Martin, in Vrútky and Dražkovce in August 2022. The nymphs were introduced to Slovakia with white pine (Pinus parviflora Siebold & Zucc.), imported in pots from the Czech Republic. The pine trees were originally purchased in Japan, where G. nigrofuscata is one of the most common cicada species. The nymphs had been developing at the locations in Slovakia for about 5 years. Based on the number of exuviae, it can be assumed that the population was large enough for the cicadas to produce a new generation. Many potted plants from Japan are popular trees, and many companies buy them directly in Japan, so it is possible that the cicada G. nigrofuscata will gradually start to appear more often in the European region.
Effect of climate change on potential distribution of Dactylorhiza hatagirea (D. Don) Soó in the twenty-first century across the north-western Himalayas
Authors: Dad Javaid M. , Rashid Irfan 
Published: January 2025

Abstract
The populations of Dactylorhiza hatagirea are shrinking fast across the north-western Himalayas. Although the effects of contemporary anthropic factors on its distribution are well documented, the impacts of anticipated climate change have not been evaluated. In the present study, the maximum entropy modelling (MaxEnt) was used to quantify the impact of climate change on the distribution of D. hatagirea over the next 50 years under representative concentration pathways (RCP) 4.5 and 8.5, using ensemble mean of four general circulation models, viz. CCSM4, CNRM, MRI, and GFDL. The results exhibited a fairly good model performance, with D. hatagirea attaining the highest suitability when ‘annual mean temperature’ and ‘annual precipitation’ peaks at ca. 11.5 °C and 1,250 mm, respectively. The variables with greater influence (%) were annual precipitation (40.7), mean temperature of the wettest quarter (22.9), precipitation seasonality (16.6), and mean annual temperature (10.4). Under the current climate, about 790 km2 that spread across Kashmir (274.1 km2) Jammu (210.5 km2), and Ladakh (305.6 km2) were identified as high potential habitat (HPH) areas. The predicted distribution showed that for RCP 4.5 the HPH areas would decrease by 4.2 and 5.4%, by 2050 and 2070, while for RC P8.5 the decrease would be 18.1 and 8.7%, respectively. The shrinkage may be more obvious across tropical and temperate regions, while the species may gain new HPH areas across cold arid areas. Although HPH shrinkage for D. hatagirea appears mild, but as it exhibits high habitat specificity and grows inherently slow, this insignificant shrinkage may enhance its risk of local extinction. Therefore, an integrated approach involving in-situ measures across regions, where the species may disappear, and ex-situ measures, where it may expand, is hugely important.
Distribution and abundance of a soil centipede, Tygarrup nepalensis Shinohara, 1965 (Mecistocephalidae: Geophilomorpha: Chilopoda) in a moist temperate forest in Northwest Himalaya
Authors: Negi Diksha , Ahmed Shakoor , Sambyal Deepali , Stašiov Slavomír , Julka Jatinder Mohan 
Published: January 2025

Abstract
This study investigates the distribution of the soil centipede, Tygarrup nepalensis (Order Geophilomorpha), in the moist temperate forest of the Northwest Himalayas, located in Himri, District Shimla, Himachal Pradesh, India. Centipedes were collected using a standardized 25 × 25 cm quadrat sampling method. We examined the influence of various environmental and edaphic parameters on its populations across different forest areas (north, northeast, southwest facing aspects). The north aspect exhibited higher density due to more favourable soil conditions, including higher phosphorus and organic carbon, which supported larger populations of detritivore earthworms, likely prey for T. nepalensis. These findings underscore the role of microhabitat characteristics in shaping centipede distribution and highlight implications for forest management strategies aimed at conserving soil biodiversity and enhancing forest productivity. Our results indicate that average soil moisture levels (25.8% to 30.5%) are conducive to the habitat requirements of T. nepalensis, which thrives in moist environments. Notably, population densities varied significantly, with lower density in the northeastern aspect, correlated with reduced soil phosphorus concentrations and increased acidity.
Effect of abiotic factors in seed germination of the medicinal aromatic plant Ziziphora hispanica L.
Authors: Djebbouri M. , Zouidi M. , Terras M. 
Published: January 2025

Summary

Ziziphora hispanica L. (Lamiaceae) is a medicinal aromatic plant which is native to Algeria in semi-arid regions, Morocco and southern Spain. Despite the medicinal and economic interests as well as the uncertain future that this species may encounter in its natural habitats, various aspects of the biology of its seeds have not been recognized up to date. To fulfill these gaps, seed germination has been studied under the effect of different incubation temperatures, and under the influence of defer-ential concentrations of water stress and saline stress. The seeds were first incubated at different temperatures (15, 20 and 25°C). Then, at 20°C, germination studies were carried out at various sodium chlo-ride concentrations (0, 25, 50, 75 and 100 Mmol /l) and various solutions of polyethylene glycol (PEG6000) (0, -0.2, -0.4, and-0.6 Mpa). The results showed that Z. hispanica seeds were not dormant, and the optimal temperature of germination was 20°C, at which the maximum final germination percentage occurred (94%). A high negative correlation was obtained between the germination percentage and the various concentrations of NaCl. In comparison to other plant species that share its habitats, the results of the water stress impact tests indicate that Z. hispanica is very sensitive to water stress, indicating difficulties in germinating in semi-arid and arid regions and that climate change may restrict its natural habitats. The results of this study can serve as guidelines for propagation protocols of this species to support its conservation and cultivation.
Same side recurrent pneumonia should be suspected as pulmonary sequestration a case report
Authors: Almahafdha Aalaa , Aljefairi Maryam , Alnasser Mustafa 
Published: January 2025

Background: Pulmonary sequestration may be intralobar or extralobar. Intralobar pulmonary sequestration occurs most often in the left lower lobe, and symptoms first occur around the age of 20. By contrast, extralobar pulmonary sequestration is restricted to the lower lobes and presents from the neonatal period. Diagnosis is suggested by chest X-ray and confirmed by computed tomography angiography. Treatment comprises vessel ligation and resection to prevent repeated chest infections and complications.
Case Presentation: We describe an 18-year-old woman who was admitted to our hospital with a history of repeated chest infection in the left lower lobe over the last two years. She was found to have intralobar pulmonary sequestration, which was managed by left lower lobectomy.
Conclusion: Pulmonary sequestration is a rare condition but should be suspected in
patients with repeated pneumonia in the same lung in early adulthood.
Señales físicas, mentales y emocionales de la pérdida del disfrute escénico en músicos académicos.
Authors: Correa Ayelen 
Published: January 2025

En este artículo se abordan los resultados de análisis de patrones repetitivos de los músicos padecientes de la presión academicista del ámbito musical. Observamos y analizamos los resultados de incidencias percibidas como miedo, ansiedad y pánico escénico en los diferentes niveles del estadío de los participantes.
Un punto diferencial de esta investigación es la correlación de los patrones determinados como síntomas del displacer escénico musical; donde se presenta qué sucede antes, durante y después de cada presentación escénica a los intérpretes entrevistados. Al mismo tiempo, aportamos una muestra internacional de músicos hispanohablantes, encontrando un punto de conexión para repensar la pedagogía académica y cómo esta, podría aportar en la prevención de la problemática.
Monsoon meteors – Varied clinical presentations of paederus dermatitis
Authors: Bejjipuram Sravanthi , Ravi S.S. , Vinnakoti Anitha , Behara Suresh Kumar 
Published: January 2025

Objectives
This study aims to highlight the different clinical presentations and the notable ability of the disease to mimic various dermatological conditions.

Material and Methods
A prospective observational investigation was executed at the DVL OPD of a tertiary care center in Andhra Pradesh over one-month duration, from July 2024 to August 2024. Overall, 30 patients suffering from Paederus dermatitis were identified.

Results
This investigation involved 30 patients with Paederus dermatitis; 23 were male and 7 were female. Most of the patients were between 20 and 50 years of age. All patients had a sudden emergence of lesions, along with burning sensations and pain. Linear erythematous pattern (43.3%) is a common clinical pattern, followed by erythematous lesion with central grey area (13.3%), kissing lesion (10%), and burnout lesion (10%). Burning is the most common symptom. The frequently affected areas are the face, neck, as well as upper extremities.

Conclusion
Paederus dermatitis has varied clinical presentations, and understanding its presentation is crucial to prevent misdiagnosis.
Computer simulation of an isotomic mapping for a given triangle
Authors: Sovertkov P.I. 
Published: January 2025

The isotomic mapping is defined constructively, i. e. after constructing the intersection point of one triple of segments and constructing the intersection point of a new triple of segments, an isotomically corresponding point appears. The article considers mathematical and computer modeling of an isotomic mapping in two ways: using Cartesian coordinates and using barycentric coordinates. The analytical definition of the mapping law allows you to quickly construct the corresponding pair of points and find the image of the line with an isotomic match.
Изотомическое отображение определено конструктивно, т. е. после построения точки пересечения одной тройки отрезков и построения тройки пересечения новой тройки отрезков, появляется изотомически соответствующая точка. В статье рассмотрено математическое и компьютерное моделирование изотомического отображения двумя способами: с помощью декартовых координат и используя барицентрические координаты. Аналитическое задание закона отображения позволˢет быстро построить соответствующую пару точек и находить образ линии при изотомическом соответствии.