bluuebunny/crossref_metadata_2025_split huggingface dataset:
Clinical significance of TP53 alterations in advanced NSCLC patients treated with EGFR, ALK and ROS1 tyrosine kinase inhibitors: An update
Authors: Moes-Sosnowska Joanna , Szpechcinski Adam , Chorostowska-Wynimko Joanna 
Published: October 2023

The development of targeted therapies for non-small cell lung cancer (NSCLC), such as the epidermal growth factor receptor ( EGFR), anaplastic lymphoma receptor tyrosine kinase ( ALK), and ROS proto-oncogene 1 ( ROS1), has improved patients’ prognosis and significantly extended progression-free survival. However, it remains unclear why some patients do not benefit from the treatment as much or have a rapid disease progression. It is considered that, apart from the oncogenic driver gene, molecular alterations in a number of caretaker and gatekeeper genes significantly impact the efficacy of targeted therapies. The tumor protein 53 ( TP53) gene is one of the most frequently mutated genes in NSCLC. To date, numerous studies have investigated the influence of various TP53 alterations on patient prognosis and responsiveness to therapies targeting EGFR, ALK, or ROS1. This review focuses on the latest data concerning the role of TP53 alterations as prognostic and/or predictive biomarkers for EGFR, ALK, and ROS1 tyrosine kinase inhibitors (TKIs) in advanced NSCLC patients. Since the presence of TP53 mutations in NSCLC has been linked to its decreased responsiveness to EGFR, ALK, and ROS1 targeted therapy in most of the referenced studies, the review also discusses the impact of TP53 mutations on treatment resistance. It seems plausible that assessing the TP53 mutation status could aid in patient stratification for optimal clinical decision-making. However, drawing meaningful conclusions about the clinical value of the TP53 co-mutations in EGFR-, ALK- or ROS1-positive NSCLC is hampered mainly by an insufficient knowledge regarding the functional consequences of the TP53 alterations. The integration of next-generation sequencing into the routine molecular diagnostics of cancer patients will facilitate the detection and identification of targetable genetic alterations along with co-occurring TP53 variants. This advancement holds the potential to accelerate understanding of the biological and clinical role of p53 in targeted therapies for NSCLC.
SEMIOTIC ANALYSIS OF VERBAL SIGNS FOUND IN FAST FOOD ADVERTISEMENTS
Authors: Saputra I Putu Ardy , Agung I Gusti Ayu Mahatma 
Published: October 2023

Advertisement is a media platform used by people or companies to promote their product on social media or in public. There are signs in every advertisement. This study is concerned with analyzing the verbal signs found in fast food advertisements. There are two aims of this study: (1) to find out the verbal signs in the fast-food advertisements and (2) to analyze the meaning of the verbal signs that are found in fast-food advertisements. This study uses a descriptive qualitative method, and the data were analyzed based on the theory by Barthes (1967) about the signifier and signified and the meaning. The result of this study shows the verbal sign in the form of written text. In this research, the researchers found twenty-seven verbal signs in fast food advertisements.
STUDENT’S DIFFICULTIES ON WRITING DESCRIPTIVE TEXT
Authors: Daulay Sholihatul Hamidah , Damanik Emeliya Sukma Dara , Annisa Nuriza 
Published: October 2023

This research investigates an overview of students' difficulties in writing descriptive text through linguistic and psychology problems. This research presents a case study as qualitative research of students in eighth grade of SMP Darussalam Medan. The sample comprised 10 students (4 males and 6 females) through purposive sampling. This study used observation, documentation, and interview. In this study, data collection from each instrument was as follows: document data collection through student descriptive writing and direct interview data collection via video call on WhatsApp. The data analysis procedure of this study was followed by Miles and Hubermen in 1984 which covered data reduction, data interpretation, and drawing a conclusion. Based on the observation result supported by the document and interview through the triangulation method, students found difficulties in using punctuation and capitalization in writing descriptive. The students’ felt difficulty in using grammar lack of vocabulary and mechanics. In addition, the practice of writing essays also makes students skilled in writing. With practice, students will know the difficulties they face in writing to know the quality of their writing.

Keywords: Difficulties, Writing skill, Descriptive text.
ANALYSIS OF STUDENTS’ ENGLISH SPEAKING ANXIETY IN LEARNING NARRATIVE TEXT THROUGH ONLINE LEARNING AT GRADE X MAN 1 INDRAGIRI HILIR
Authors: Sauhana Felci Tria , Purwanti Sri Erma , Drajat Siti Zakiyah 
Published: October 2023

Speaking anxiety was the main problem in this research. Students found it was difficult in pronouncing or spelling the words and they were afraid of making mistakes in speaking English. This research was aimed to find out the level of students' English speaking anxiety in learning narrative text through online learning. This research was conducted at MAN 1 Indragiri Hilir, Tembilahan. The particiants of this research were the students at grade XI IPA 2 MAN 1 Indragiri Hilir which consists of 34 students. Sampling was done by using purposive sampling technique. This research used a quantitative descriptive method and distributed questionnaires to collect the data. Based on the result of the research, there were 7 indicators of speaking anxiety. They were being blank, forgetting the words they have read, unable to say what they know, less interested in the learning process, silent, afraid of miscommunication, and avoid talking. Based on this analysis, it was concluded that the result of this research indicated that "forgetting the words they have read” was the dominant indicator of students anxiety with category very anxious (80%). The result was 70,43% in the anxious category.
TEACHING READING STRATEGY FOR YOUNG LEARNERS
Authors: Maizarah Maizarah , Purwanti Sri Erma 
Published: October 2023

Nowadays English is a compulsary subject must be taught for students, because English is global language. English has some skills namely listening, speaking, reading and writing. One of the important skills is reading, because through reading students will have broad insight, so the habit of reading has to start with students in Elementary. Elementary students are English young learners that should be facilitated well in their learning reading by using good strategy. Teaching English for young learner is different with teaching English for adult learner. Young learners have different characteristics and learning preference. In teaching reading, English teachers should implement appropriate strategies and interesting to young learners which can be a stimulus to become active students and participate in teaching and learning process. Therefore, this article aimed to explain some reading strategies that can be applied by the teachers for young learners. The method employed is library research which has four steps to collecting the data namely note-taking, outlining, describing, and draw conclusion. The strategies that are described are Emergent Literacy, Mnemonic Strategy, Read aloud strategy, Decoding Strategy, and Language Experience Approach.
STUDENTS' ABILITY IN PRONOUNCING ENGLISH FRICATIVE CONSONANTS AT ENGLISH LANGUAGE EDUCATION OF FKIP UIR
Authors: Maysarah  , Idayani Andi , Sailun Betty 
Published: October 2023

This research aims to know the students' ability to pronounce English Fricative consonants at English Language Education of FKIP UIR. The design of this research is descriptive research with a qualitative approach. The researcher conducted the study at English Education of FKIP UIR. The researcher took 30 students from 65 second-semester students' at English Education of FKIP UIR. In this research, the researcher used the purposive sampling technique. The research instrument is a pronunciation test consisting of 26 words, and a recorder collected the data. The online Cambridge-American dictionary is used as the correction standard by the researcher. The result of data analysis showed that the average score for students' pronunciation was 19,62, with scores ranging from 7.4. Afterward, the findings revealed that students still have many problems pronouncing English fricatives, especially in /f/, /θ/, and /ʒ/ sounds. Meanwhile, the researcher found the most trouble when students were pronouncing the fricative sound /ʒ/ in the initial position. After that, the sound /f/ in the medial and /ʒ/ in the final position have the same lower score. Then, there is a problem when students pronounce the /θ/ sound and the/ sound in the final position. In conclusion, the student's ability to pronounce English fricative consonants at FKIP UIR English Language Education is fairly good.
ANALISIS KERAGAMAN GEN Follicle Stimulating Hormone (FSH) PADA ITIK PITALAH SUMATERA BARAT
Authors: Haryati Stefani Fitri , Subekti Kusnadi , Arlina Firda , Rusfidra Rusfidra , Husmaini Husmaini , Amelia Riska 
Published: October 2023

Abstrak Itik Pitalah merupakan salah satu sumber daya genetik yang telah disahkan sebagai rumpun itik lokal asli Sumatera Barat. Keunggulan yang dimiliki oleh itik Pitalah adalah daya adaptasi yang baik. Follicle Stimulating Hormone (FSH) berperan dalam proses perkembangan folikel dan sekresi hormon steroid yang berfungsi dalam proses pembentukan kuning telur. Penelitian ini bertujuan untuk menganalisis keragaman gen Follicle Stimulating Hormone (FSH) pada itik Pitalah Sumatera Barat dengan menggunakan sampel darah dari 45 ekor itik Pitalah betina. DNA isolasi diamplifikasi dengan menggunakan sepasang primer forward dan reverse yang didesain berdasarkan GeneBank DQ232890.1 dengan target fragmen 318 bp. DNA hasil amplifikasi disekuensing menggunakan jasa 1st Base Singapore untuk mengetahui keragaman gen Follicle Stimulating Hormone (FSH). Hasil penelitian menunjukkan bahwa terdapat 11 titik keragaman pada daerah target gen Follicle Stimulating Hormone (FSH). Keragaman gen Follicle Stimulating Hormone (FSH) ini bersifat polimorfik dan populasi itik Pitalah tidak berada dalam keseimbangan Hardy-Weinberg.Kata kunci: FSH; Itik Pitalah; Keragaman; Mutasi; Sekuensing
Stochastic Programming Model in Least Cost Feed Formulation for Lactating Cattle
Authors: Patil Vishal , Gupta Radha , Rajendran D. , Kuntal Ravinder Singh , Chanda Manasa 
Published: October 2023

A conventional linear programming model (LPM) for feed formulation of lactating cattle will overlook the variation in feed components. LPM only considers the mean composition of feed values, regardless of variations, the confidence in satisfying the nutrient need falls to 50%. Whereas the stochastic model (SM), which takes into account both the mean and variation of feed composition and provides 90-99% confidence in meeting the nutrient need. In present work, we have proposed SM for least-cost feed formulation of lactating cattle where the variation in the composition of nutrients like crude protein (CP), Calcium (Ca) and Phosphorus (P) in the feedstuff are considered. Data provided by the National Research Council (2001) are the basis for the current analysis. These SMs are resolved using M.S. Excel's Generalized Reduced Gradient (GRG) nonlinear and LINGO's Nonlinear solver, and the results are compared to LPM; the feed formulated by SM (90 % and 99 %) has the lowest cost when compared to LPM. Nutrients estimated by LPM, SM by GRG nonlinear, and SM by Nonlinear solver utilized for feed formulation had no significant differences as (p>0.05). When compared to LPM, the stochastic model is a better technique, particularly when dealing with nutrient variation.
Eserleri Meşhur Meçhûl Bir Âlim: Şemseddîn en-Niksârî’nin Entelektüel Kişiliği
Authors: ERDİNÇ Ziya 
Published: October 2023

Yaşadıkları dönemde fikirleri ve eserleriyle etkili olan bazı İslâm âlimleri, sonraki yüzyıllarda çeşitli sebeplerden dolayı ilim dünyasında meçhul düşünürler arasında yerini alabilmektedir. Şemseddîn en-Niksârî, bu olgunun dikkat çekici örneklerinden biridir. Kendi dönemi ve hemen sonrasında kelâm, fıkıh, dil ilimleri gibi alanlarda görüşleri ve eserleriyle âlimleri etkilemiş olan Şemseddîn en-Niksârî, tabakat ve terâcim kitaplarında göz ardı edilmiştir. Bu durum, onun eserlerinin, kendisinden bir asır sonra yaşamış ve kaynaklarda hayatına dair detaylı bilgi bulunan Muḥyiddîn en-Niksârî’ye nispet edilmeye başlanması ile sonuçlanmıştır. Kâtib Çelebî’nin Şemseddîn en-Niksârî’yi Muḥyiddîn en-Niksârî ile aynı kişi gibi görüp eserlerini ona nispet etmesi, sonraki literatürü etkilemiş ve eserleri Muḥyiddîn en-Niksârî’nin ismiyle ilim dünyasında yaygınlık kazanmıştır. Dolayısıyla Şemseddîn en-Niksârî’nin entelektüel kişiliğinin belirlenebilmesi için öncelikle eserleri delillere dayalı olarak tespit edildikten sonra içerikleri incelenmiş ve gerek onun eserleri gerek onunla yakın dönemde yaşamış âlimlerin benzer konularda telif ettikleri eserlerinin yazma nüshaları incelenmiştir. Böylece Şemseddîn en-Niksârî’nin ilmi şahsiyeti, hoca ve öğrencileri tespit edilmeye çalışılmıştır.
Yapılan araştırma sonucunda 8./14. yy.’da yaşamış Hanefî-Mâtürîdî âlim Şemseddîn en-Niksârî’nin Ḥusâmüddîn es-Sıġnâḳî ve Şerefüddîn et-Tîbî gibi hocalardan ders aldığı; aralarında Şerefüddîn es-Surmârî ve Çandarlı Kara Halil Hayrettin Paşa’nın bulunduğu öğrencilere de ders verdiği belirlenmiştir. Aklî ve naklî ilimlerde yetkinliğe sahip olan müellif; kelâm ilminde Şerḥu’l-ʿUmde ve Şerḥu’l-Emâlî, belâgatte Şerḥu’l-Îḍâh, nahivde Mes’eletü’l-Kuḥl ve sarf alanında ise Şerḥu’l-Hârûniyye eserlerini telif etmiştir.
Bu çalışmada Şemseddîn en-Niksârî’nin hatalı bir şekilde Muḥyiddîn en-Niksârî’ye nispet edilen eserlerdeki bilgilerden, eserlerin yazma nüshalarındaki metin dışı kayıtlardan (ḳuyûdât) (ferağ kaydı, zahriye, derkenar notları vb.) ve ikincil kaynaklardan hareketle onun ilmî kişiliği, hocaları, öğrencileri ve eserleri tespit edilmeye çalışılmıştır.
Early Adolescent Girls Develop Their Self-Worth through Participation and Achievement
Authors: Nau Erin 
Published: October 2023

Abstract
2022 marked 50 years since the passing of Title IX, which allowed girls and women to have equal opportunities to participate in sports. One of the impacts this bill has had on girls is that participation and achievement in sports help early adolescent girls develop their self-worth. A finding from a recent phenomenological study on early adolescent girls’ self-worth found that girls develop self-worth through feeling competent in important capacities in their lives. This article will focus especially on the development of self-worth as it connects participation in sports to the impact of Title IX on girls. Furthermore, the participants’ related understanding of misogyny, violence against women, and achievement in a patriarchal society will be discussed in order to improve safety and inclusion for girls in sports.
Profil Kebugaran Jasmani Aspek Daya Tahan Vo2max Siswa SD Negeri 27 Bengkulu Tengah
Authors: Pirsan  , Sugihartono Tono , Sutisyana Ari 
Published: October 2023

ABSTRACT
The purpose of study was to determine the physical fitness profile of the VO2 Max endurance aspect of the students of SD Negeri 27 Bengkulu Tengah. This type of research was descriptive qualitative research. The research subjects were students in grades III, IV, V and VI of SD Negeri 27 Bengkulu Tengah. To analyze the file , the researcher used the multi fitness test (MFT)VO2 Max instrument (arrival back and forth 20 meters). The results of file analysis obtained 21 (29.16%) male students with a value score of VO2 Max <25 with a very bad category, 33 (45 ,83%) of male students with a value score of VO2 Max 25.0 - 33.7 category with a poor category, 17 (23.61%) male students with a value score of VO2 Max 33.8 - 42.5 in the medium category, 1 (1.38% )of male students with a value score of VO2 Max 42.6 was in the good category and 0 (0%) no male students in the very good category. The average V02max of male students was at a value score of VO2 Max 28.91 with a poor category. Mean while, female students found 52 (72.22% ) female students with a value score of VO2 Max <25 in the very bad category, 19 (26.38% ) female students with a value score of VO2 Max score 25.0 - 33.7 with bad category, 1(38% ) female student with a value score of VO2 Max 33.8 - 42.5 in the medium category, 0 (0%) no female students in the good category and 0 (0%) no female students in the very good category. The average V02max of female students was at a value of 24,23 with a very poor category. The average results of physical fitness aspects of endurance VO2 Max students of SD Negeri 27 Bengkulu Tengah were at a value of 26,57 with a bad category.
Keywords: Physical Fitness, students of SD Negeri 27 Bengkulu Tengah, Aspects of Endurance VO2 Max
Pengaruh Latihan Kekuatan Otot Lengan Terhadap Kemampuan Tembakan Hukuman (Free Throw) Dalam Permainan Bola Basket Putra Club Adhyaksa Kepahiang
Authors: Andriyani Meza , Yarmani  , Rizky Oddie Barnanda 
Published: October 2023

Penelitian ini bertujuan untuk mengetahui pengaruh latihan kekuatan otot lengan terhadap tembakan hukuman (free throw) dalam permainan bola basket club adhyaksa kepahiang. Jenis penelitian ini adalah kuantitatif. Populasi dalam penelitian ini adalah atlet bola basketclub adhyaksa yng berjumlah 55 atlet. Desain penelitian yang digunakan adalah one-group pretest-posttest. Teknik pengambilan sampel yng digunakan tersebut adalah proposive sampling. Dengan demikian jumlah sampel dalam penelitian ini adalah sebanyak 20 atlet basket putra club Adhyaksa Kepahiang. Perlakuan yang diberikan yaitu Latihan Kekuatan Otot Lengan yng terdiri dari latihan Squat Thrust, Latihan lempar tangkap bola dan latihan pull up. Teknik pengumpulan data dalam penelitian ini dengan metode tes secara langsung yaitu menggunakan tes tembakan hukuman (Free Throw) selama 1 menit . Uji persyarat statistik memenuhi syarat homogen dan data berdistribusi normal berdasarkan hitungan statistik didapat hasil dari data T hitung = 8.91 > T tabel = 2.093 dengan taraf = 0.05. Hasil penelitian ini menunjukkan terdapat pengaruh antara Latihan kekuatan otot lengan terhadap kemampuan Tembakan Hukuman (Free Throw) dalam bola basket pada club Basket Adhyaksa Kepahiang, sehingga dapat disimpulkan bahwa latihan kekuatan otot lengan mempengaruhi peningkatan bola yang masuk ke dalam ring basket pada tes (Free Throw) dan dapat dijadikan metode latihan untuk meningkatkan prestasi atlet.
GAYA KEPEMIMPINAN KEPALA MADRASAH DALAM MEWUJUDKAN MADRASAH BERBASIS KARAKTER DI MIT NURUL FALAH MASOHI MALUKU TENGAH
Authors: Setyawati Nunung Dwi 
Published: October 2023

The quality of education in madrasahs is very dependent on the management ability of the head of the madrasa. The quality of the madrasa will be realized because it is led by a professional madrasa head. Character education is expected to be applied in madrasahs to answer the wishes of the community. This study aims to find out how the leadership style of the madrasah head and the efforts of the madrasah head to develop a character-based madrasah at MIT Nurul Falah Masohi. The type of research used in this study is a qualitative descriptive type of research, with data collection techniques by means of observation, interviews and documentation which are then analyzed using the data reduction stage, data presentation and data conclusions.The results of the study concluded that the Head of MIT in leading his madrasa used a democratic and autocratic leadership style. The efforts of madrasah heads in realizing character-based madrasahs include collaborating with IHF (Indonesia Heritage Foundation) to obtain guidance and assistance. The next effort of the head of MIT is to carry out the following steps 1) Attending Training and Mentoring character schools, 2) Implementing a Teacher Mentoring Program, 3) Conducting a Character-Based Curriculum Preparation Work Meeting, and 4) Implementing Guidance and Counseling. Some of the suggestions presented are that there needs to be a soldering of the head of the madrasa for the sake of the effectiveness of the madrasa p[rogram character at MIT Nurul Falah Masohi. Mutu Pendidikan pada madrasah sangat bergantung pada kemampuan manajemen kepala madrasah. Kualitas madrasah akan terwujud karena dipimpin oleh kepala madrasah yang profesional. Pendidikan karakter sangat diharapkan diterapkan di madrasah untuk menjawab keinginan masyarakat. Penelitian ini bertujuan untuk mengetahui bagaimana gaya kepemimpinan kepala madrasah dan upaya kepala madrasah untuk mengembangkan madrasah berbasis karakter di MIT Nurul Falah Masohi. Tipe penelitian yang digunakan dalam penelitian ini yakni tipe penelitian deskriptif kualitatif,dengan teknik pengumpulan data dengan cara observasi, wawancara dan dokumentasi yang kemudian dianalisis dengan menggunakan tahap reduksi data, penyajian data dan kesimpulan. Hasil penelitian bahwa Kepala MIT dalam memimpin madrasahnya menggunakan gaya kepemimpinan demokrasi dan otokrasi. Upaya kepala madrasah dalam mewujudkan madrasah berbasis karakter diantaranya adalah bekerja sama dengan IHF (Indonesia Heritage Foundation) untuk mendapatkan panduan dan pendampingan. Upaya kepala MIT selanjutnya adalah melakukan langkah-langkah sebagai berikut 1) Mengikuti Pelatihan dan Pendampingan Sekolah Karakter, 2) Melaksanakan Program Mentoring Guru, 3) Melaksanakan Rapat Kerja Penyusunan Kurikulum Berbasis Karakter, dan 4) Melaksanakan Bimbingan dan Konseling. Beberapa saran yang disampaikan adalah perlu ada pengkaderan kepala madrasah demi keberlangsungan program madrasah berkarakter di MIT Nurul Falah Masohi.
ANALISIS NILAI MORAL PADA HIKAYAT ASAL MULA BATU TINGGI DARI DAERAH SEKADAU
Authors: Sindiana Eprina , Sulastri Saptiana 
Published: October 2023

Judul penelitian Analisi Nilai moral Pada Hikayat Asal Mula Batu Tinggi,Rumusan masalah penelitian ini adalah bagaimanakah nilai moral yang berkaitan dengan hubungan manusia dengan Tuhan, hubungan dengan sesama manusia dan hubungan dengan lingkungan yang terkandung dalamhikayat asal mula batu tinggi? Tujuan penelitian untuk mendeskripsikan nilai moral yang berkaitan dengan hubungan manusia dengan Tuhan,hubungan dengan sesama, dan hubungan manusia dengan lingkungan yang terkandung dalam hikayat asal mula batu tinggi . Teknik pengumpulan data menggunakan teknik studi dukumenter. Berdasarkan hasil penelitian dan pembahasan terhadap hikayat asal mula batu tinggi dapat ditarik kesimpulan bahwa nilai moral dalam hubungan manusia dengan Tuhannya ditemukan 1 kutipan, nilai moral hubungan manusia dengan sesama ditemukan 4 kutipan, nilai moral hubungan dengan lingkungan ditemukan 2 kutipan. Maka dapat disimpulkan bahwa dalam hikayat asal mula batu tinggi banyak terkandung nilai moral yang berkaitan dengan hubungan manusia dengan sesama.

Kata kunci: Analisi,nilai moral,hikayat.