bluuebunny/crossref_metadata_2025_split huggingface dataset:
Pharmaceutical sponsors and contract research organization’s perception toward genetic data reuse for future research
Authors: Devarinti Revanasiddappa , Ganachari M. S. 
Published: November 2023

Abstract

Background:
Pharmaceutical sponsors and Contract research organization plays vital role in the preparation and implementation of clinical trials and give rise to ethical predicaments that pertain to various aspects such as general or genetic consent, optional research, storage and utilization of genetic data and specimens, as well as disclosure of research findings to study participants.

Objective:
The current investigation is to assess the knowledge, attitudes, and practices of Clinical Research Organizations and Pharmaceutical Sponsors in relation to re-use of genetic research data for future research.

Study Participants and Methodology:
A cross-sectional study conducted on pharmaceutical sponsor and their representatives from the metro cities, India.

Results:
The present research encompassed N=50 of pharmaceutical sponsors and contract research organizations. Among these, 84% evinced cognizance regarding the re-use of genetic data in clinical trials. Furthermore, 62% of pharmaceutical sponsors and contract research organizations articulated apprehensions with respect to ethical and legal quandaries might arise due to the re-use of genomic data.

Discussion:
A considerable proportion of participants are a willingness to share and reuse genetic data for future studies. However, it is observed that the perception towards practice is low, particularly in relation to the return of genetic results and ethical concerns while storing genetic samples.

Conclusion:
There are presently no universally accepted international Conference on Harmonization of Technical Requirements for Pharmaceuticals for Human Use (ICH) guidelines in place for the management of genetic sampling and data at the global level. In India, however, ICMR regulations exist to provide direction for the use of biological materials and datasets in research.
The Role and Importance of a City and District Police as Bodies of Administrative Justice in the Context of the Integration of Siberia into the Russian Empire in 1782–1862
Authors: Voropanov Vitaliy A. 
Published: November 2023

The creation and development of the police administration system in Siberia was one of the most important aspects of the state's regional policy. The purpose of this study is to determine the role and significance of city and zemstvo police as administrative justice bodies in the context of Siberia's integration into the Russian Empire from 1782 to 1862. This perspective offers a new approach to studying the integration of the macro-region into Russia. The study is based on the concept of frontier modernization, whose legal aspects have not been explored in science. The sources used include regulatory legal acts of the Russian Empire and records management materials extracted from the funds of the Russian State Historical Archive, the Archive of the Altai region, and the State Historical Archive of the Omsk region. The author concludes that the legislative decisions of the imperial power regarding the development of police administration bodies took into account the geographical, demographic, economic, and ethno-cultural characteristics of Siberia and its various regions. The legislation established specific functions and powers for city and zemstvo police in the field of justice. The activities of these bodies as administrative justice organs have become a significant factor in the defrontierization and subsequent modernization of the vast eastern periphery of the Russian Empire.
The Image of Austro-Hungary as Depicted in the “Russian Invalid” Newspaper during the Initial Years of World War I (1914–1915)
Authors: Frolov Vasiliy V. 
Published: November 2023

The article examines and analyzes the portrayal of Austro-Hungary by correspondents of the Russian daily newspaper, “Russian Invalid,” during 1914–1915. This was a period when the Russian Empire was actively engaged in military conflict with the states of the Triple (and later, Quadruple) Alliance on the European front, with Austro-Hungary emerging as one of its primary adversaries on the Eastern Front. Established in February 1813, the “Russian Invalid” was the official print publication of the Military Ministry of the Russian Empire and served as a pivotal source of information on the empire’s foreign policies. This state-run newspaper was financed by the budget of Russia’s Military Ministry. In the early stages of World War I (1914–1915), the “Russian Invalid” correspondents devoted significant attention to the Austro-Hungarian Empire. Only Germany, Britain, and France received more coverage in this publication. The majority of the information about Austro-Hungary appeared under sections titled “Military Chronicle,” “Feuilleton,” “War,” “Telegram,” and “Articles.”
The study concludes that during World War I, the “Russian Invalid,” the daily newspaper of the Military Ministry of the Russian Empire, played a pivotal role in shaping public opinion within the empire. It crafted diverse images of the states involved in the early 20th century’s major military conflict, designating them as either “enemy,” “neutral state,” or “ally.” The Austro-Hungarian Empire was depicted as a nation that had significantly exhausted its economic, military-technical, and human resources in the initial two years of the war. Such depletion was foreseen to not only incite widespread national unrest but also accelerate the empire’s eventual disintegration, an entity long referred to as a “prison of nations.”
Contemporary Approach to Reverse Logistics and Environmental Sustainability the Moderating Role of Government Support
Authors: Sarpong Kwame Owusu , Oppong Michael 
Published: November 2023

Purpose: Reverse logistical methods are becoming more popular among corporations as a means of promoting environmental sustainability, raising concerns about environmental sustainability. Therefore, the study aims to assess the relationship between reverse logistics, environmental sustainability, and government support.
Methodology: The study employed a quantitative research approach and descriptive research design. The study used a sample of 102 employees from firms in Accra Metropolis. The study adopted a purposive sampling technique in selecting the participants from the various firms in the Accra metropolis. A structured questionnaire was used as a data collection instrument. Descriptive statistics such as mean and standard deviation were used to test the reverse logistics, environmental sustainability, and government support. Multiple regression test was used to analyze the impact of reverse logistics practices on environmental sustainability, the impact of government support on environmental sustainability and the moderating role of government support with reverse logistics practices on environmental sustainability.
Findings: There is a positive and statistically significant impact of reverse logistics practices on environmental sustainability.
Unique contribution to theory, practice and policy: The study recommends that organizations should focus on optimizing product returns, recycling, remanufacturing, and waste reduction processes through adopting reverse logistics and government support.
An improvement of the CNN-XGboost model for pneumonia disease classification
Authors: Hedhoud Yousra , Mekhaznia Tahar , Amroune Mohamed 
Published: November 2023

PurposeX-ray images are viewed as a vital component in emergency diagnosis. They are often used by deep learning applications for disease prediction, especially for thoracic pathologies. Pneumonia, a fatal thoracic disease induced by bacteria or viruses, generates a pleural effusion where fluids are accumulated inside lungs, leading to breathing difficulty. The utilization of X-ray imaging for pneumonia detection offers several advantages over other modalities such as computed tomography scans or magnetic resonance imaging. X-rays provide a cost-effective and easily accessible method for screening and diagnosing pneumonia, allowing for quicker assessment and timely intervention. However, interpretation of chest X-ray images depends on the radiologist’s competency. Within this study, we aim to suggest new elements leading to good interpretation of chest X-ray images for pneumonia detection, especially for distinguishing between viral and bacterial pneumonia.Material and methodsWe proposed an interpretation model based on convolutional neural networks (CNNs) and extreme gradient boosting (XGboost) for pneumonia classification. The experimental study is processed through various scenarios, using Python as a programming language and a public database obtained from Guangzhou Women and Children’s Medical Centre.ResultsThe results demonstrate an acceptable accuracy of 87% within a mere 7 seconds, thereby endorsing its effectiveness compared to similar existing works.ConclusionsOur study provides a model based on CNN and XGboost to classify images of viral and bacterial pneumonia. The work is a challenging task due to the lack of appropriate data. The experimental process allows a better accuracy of 87%, a specificity of 89%, and a sensitivity of 85%.
Fenomena Digital Pembelajaran Berdiferensiasi Untuk Memaksimalkan Potensi Peserta Didik Bermetode Brackinalyde Berbasis Tensesdukling
Authors: Dewi Hartini 
Published: November 2023

Akibat dari dampak kebijakan zonasi yang diterapkan di sekolah pada kurikulum merdeka belajar, ditemukan perbedaan fisik, kesehatan, dan prilaku yang tak mampu ditolak oleh lemabaga. Rumusan masalah yang diangkat adalah bagaimana deskripsi peserta didik yang mengalami perbedaan dalam belajar sehingga menerapkan pembelajaran berdiferensiasi di SMAN I Tumpang? Bagaimana pola dan model belajar yang digunakan oleh guru dalam menerapkan pembelajaran berdiferensiasi? Bagaimana dampak yang terjadi akibat penerapan pembelajaran berdiferensiasi pada peserta didik di kelas X berkurikulum merdeka belajar? Berapa prosentase ketuntasan belajar fisika yang diperoleh akibat model belajar yang digunakan dalam pembelajaran berdiferensiasi? Tujuan penelitian mendeskripsikan peserta didik yang mengalami perbedaan kondisi dengan teman lainnya, mendeskripsikan pola dan model belajar yang digunakan dalam menerapkan pembelajaran berdiferensiasi, mendeskripsikan dampak yang terjadi akibat penerapan pembelajaran berdiferensiasi, menghitung prosentase ketuntasan belajar fisika dalam kelas pembelajaran berdiferensiasi. Jenis penelitian deskriptif kualitatif disertai kuantitatif sederhana, teknik analisa data menggunakan fenomenologi bermetode brackinalyde. Teknik pengambilan data selain wawancara juga dokumentasi nilai formatif maupun sumatif. Instrument pembelajaran berdiferensiasi berbasis Tensesdukling. Simpulan ditemukan peserta didik yang berbeda dengan kondisi disabilitas kognitif, sensorik, fisik, dan peserta didik dengan perbedaan emosional atau sosial. Pola dan model pembelajaran berdiferensiasi meliputi pola model belajar online atau berbantuan teknologi, pembelajaran berbasis minat, role playing, pembelajaran dalam kelompok fleksibel. Dampak positif yang ditemukan bahwa pembelajaran berdiferensiasi memberikan kemampuan kepada peserta didik yang berbeda untuk memaksimalkan potensinya menjadi tuntas pada pembelajaran fisika. Dampak negative bagi lingkungan proses belajar mengajar. Lingkungan akan memberikan stigma bahwa guru memperlakukan korban sebagai anak emas. Prosentase kentutasan fisika rata-rata pada kelima kelas sebesar 98,8%.
Density of mollusc biota Genus Nerita in the littoral zone, Simeulue Tengah District, Simeulue Regency, Aceh Province
Authors: Hermi Rudi , Mursawal Asri , Heriansyah Heriansyah , Nasution Muhammad Arif , Munandar Munandar , Wahyuni Sri , Rizal Muhammad , Khairi Ikhsanul , Akbardiansyah Akbardiansyah 
Published: November 2023

Kabupaten Simeulue adalah salah satu Kabupaten yang berada di Provinsi Aceh. Kabupaten ini merupakan Kabupaten Kepulauan dengan kriteria pantai pasir dan berbatu. Kecamatan Simeulue Tengah terletak pada bagian tengah Pulau yang pada bagian selatan berbatasan langsung dengan Samudera Hindia. Penilitian Biota Moluska Genus Nerita dilakukan di Kecamatan Simeulue Tengah Kabupaten Simeulue dilakukan untuk mengetahui Spesies apa saja yang terdapat diokasi penelitian dan untuk mengetahui ukurannya. Pengambilan sampel ditetapkan 5 titik pengamatan selama 7 hari pada bulan Desember tahun 2022. Teknik pengumpulan sampel secara Purposive Sampling dan dilaksanakan pada malam hari. Data dianalisis secara deksriptif dengan cara mengidentifikasi morfologi, untuk analisis ukuran Nerita menggunakan software Image J. Hasil penelitian ditampilkan dalam bentuk gambar dan tabulasi. Dari hasil penelitian ditemukan 5 spesies Genus Nerita dengan ukuran yang berbedah-bedah. Panjang cangkang spesies yang ditemukan adalah 2,09 cm sampai dengan 3,21 cm, dengan lebar cangkang antara 1,74 cm sampai 2,05 cm. Sedangkan panjang operculum berkisar antara 0,97 cm sampai 1,28 cm.
Upadacitinib (Rinvoq)
Authors: CADTH  
Published: November 2023

CADTH reimbursement reviews are comprehensive assessments of the clinical effectiveness and cost-effectiveness, as well as patient and clinician perspectives, of a drug or drug class.
The assessments inform non-binding recommendations that help guide the reimbursement decisions of Canada's federal, provincial, and territorial governments, with the exception of Quebec.
This review assesses upadacitinib (Rinvoq) 15 mg, 30 mg, and 45 mg extended-released tablets, oral administration.
Indication: For the treatment of adult patients with moderately to severely active ulcerative colitis whose condition has not responded to treatment, i.e., have had an inadequate response, loss of response, or intolerance to at least 1 of the conventional and/or biologic therapies.
A ATUAÇÃO DA FISIOTERAPIA NO PRÉ PARTO EM GESTANTES
Authors: Veloso Ana Luiza Gonçalvis , Lima Janeide Gonçalves de , Nascimento Naahman da Silva Neves , Alves Éricles Dias 
Published: November 2023

Introdução: A gestação representa um momento único é muito importante na vida das mulheres, que é marcada pela transformação da maternidade, trata-se de um processo fisiológico que envolve inúmeras mudanças físicas, hormonais e psicológicas. A atuação da fisioterapia na gestação visa promover a prevenção de complicações, desconfortos e disfunções musculoesqueléticas e uroginecológicas. Objetivos: Demonstrar técnicas de fisioterapia no pré parto, que buscam facilitar o parto vaginal, diminuir o tempo do trabalho de parto e fazer com que a gestante esteja mais bem preparada para o parto. Metodologia: Este estudo trata-se de uma revisão bibliográfica realizada através da base de dados da SciELO (Scientific Eletronic Library Online), LILACS, Brazilian Journal of Development (BJD), Biblioteca virtual em saúde (BVS), PubMed, Repositório Universitário da Ânima (RUNA). Conclusão: O papel do fisioterapeuta no pré parto é de suma importância pois seus benefícios são satisfatórios e de grande eficácia, proporcionando o aumento do autoconhecimento, da confiança e do bem-estar da gestante durante o trabalho de parto prevenindo complicações tanto para mãe quanto para o bebê.
Determination of the effect of pre-mating weight and placental characteristics on birth weight in Karayaka sheep
Authors: Urun Samet , Şirin Emre 
Published: November 2023

Abstract. The aim of this study was to determine the effect of the pre-mating weight and placental characteristics on birth weight. Data were collected from 62 Karayaka ewes and 70 Karayaka lambs. The placental characteristics considered were placental weight, placental area and the number of cotyledons. The Pearson correlation coefficient was used for statistical comparison and the determination of relationships between variables. In addition, correlation coefficients between live weights and placental characteristics were determined. The average birth weight (BW), pre-mating weight (PMW), placental weight (PW), placental area (PA) and cotyledon number (CN) values were 4.37 ± 0.70 kg, 50.22 ± 5.63 kg, 362.51 ± 118.42 g, 994.18 ± 312.76 cm2 and 56.93 ± 8.06, respectively. BW had positive correlations with PMW (0.147), birth type (BT) (0.643), PW (0.604), PA (0.323) and CN (0.161) (P < 0.05). BW had negative correlations with maternal age (MA) (−0.119) (P < 0.05). PMW had positive correlations with maternal age (MA) (0.237) (P < 0.05). PMW had negative correlations with S (sex) (−0.003), PW (−0.049), PA (−0.067) and CN (−0.080) (P > 0.05).
Responsabilidade social empresarial: o valor social produzido pelas empresas de capital aberto no estado do Maranhão
Authors: Guedes Kelvin Felipe , De Carvalho Hugo Leonardo Menezes 
Published: November 2023

O presente artigo tem como objetivo analisar a relação existente entre as práticas de Responsabilidade Social Empresarial (RSE) e o valor de mercado das empresas, notadamente aquelas que possuem sede de atuação no Estado do Maranhão. Isso porque, segundo a Teoria dos Stakeholders, as empresas precisam alinhar os seus interesses aos anseios e expectativas de todos os agentes com quem ela se relaciona. Com isso, espera-se que a perspectiva de atuação das empresas não seja pautada apenas para seus acionistas, mas sim no alinhamento e harmonização com o que esperam os stakeholders, mas existem dúvidas de como os gestores decidem e priorizam acerca desse alinhamento. A valorização de mercado é uma importante variável de geral de valor para os acionistas. Para tanto, realizou-se regressão linear múltipla com amostra de 28 empresas listadas na B3, em que a variação do preço das ações foi a variável resposta e o Índice de Sustentabilidade Empresarial (ISE B3) a variável independente principal junto com outras de controle. Os resultados evidenciaram que, para o período analisado, houve significância estatística para a relação testada, mas que a correlação encontrada foi diferente daquela esperada. Isso pode indicar que as práticas de RSE das empresas estejam relacionadas a outros indicadores que não a valorização de mercado. Apesar disso, destaca-se ainda que, para a realidade do Estado do Maranhão, as três empresas escolhidas para análise mais detalhada (Vale, Equatorial e Grupo Mateus) ainda possuem ações tímidas em termos de práticas de RSE direcionadas às carências das localidades e comunidades do Estado.
Remoción de arsénico en agua con zeolitas naturales provenientes del norte y centro de México
Authors: Colmenero Sujo Luis Humberto , Villalba María de Lourdes 
Published: November 2023

Adsorción e intercambio iónico son consideradas como las técnicas efectivas y factibles para remover metales pesados del agua. Investigaciones recientes han reportado el uso de zeolitas para remover arsénico del agua. En México se han identificado grandes yacimientos de este mineral, tanto en el norte, centro y sur del país, con diferencias importantes debido al ambiente geológico e influencia ambiental donde se encuentran. El objetivo fue conocer la remoción de arsénico en agua que presentan las zeolitas naturales provenientes del norte y centro de México. Se seleccionaron dos yacimientos uno en el estado de Chihuahua (MACh) y otro en el estado de Guanajuato (MSF). Se caracterizaron geológica, física y químicamente mediante diferentes técnicas: petrografía (láminas delgadas), difracción de rayos X (DRX) y microscopía electrónica de barrido (MEB). Se realizaron isotermas de adsorción, cinética de adsorción, finalmente se midió la capacidad de adsorción mediante columnas empacadas. Los minerales presentaron diferente composición (tipo y proporción de zeolitas), así como la relación Si/Al. Las pruebas de isotermas de adsorción, cinética de adsorción y columnas empacadas demostraron la capacidad de remoción de cada material, siendo la zeolita proveniente del centro de México que ofrece mayor retención por intercambio iónico.

DOI: https://doi.org/10.54167/tch.v17i3.1261
Automated web testing over the last decade: A systematic literature review
Authors: Mridha Nafis Fuad , Mahbubul Alam Joarder  
Published: November 2023

Web applications play a vital role in every section ranging from business to administration, making operations efficient. Reliability must be ensured to avoid loss of credibility and revenue. Testing modern web applications is very tedious due to their dynamic and asynchronous nature. Web applications evolve rapidly to serve the growing needs of the customers and manual testing is often infeasible to maintain the reliability and validity of the system due to time and resource constraints. Automated web application testing is an ongoing popular research domain due to the complexity imposed by web applications. This paper conducts a systematic literature review on the practices of automated web testing over the past decade. PRISMA framework is used to screen the most relevant research papers using Scopus and Web of Science as the database. A total of 26 papers were selected based on the inclusion criteria and quality assessment. The articles were fetched and their contributions are documented to know about current practices and the effectiveness of such approaches in minimizing human effort. Results indicate broadly two categories of automated testing, one depending on the tester’s expertise to generate test cases, and the other relying on crawlers to exploit the system dynamically.
TRÁFICO INTERNACIONAL DE MULHERES PARA FINS DE EXPLORAÇÃO SEXUAL
Authors: Ferreira Michelly Sanny , Serafim Lauane Ferreira 
Published: November 2023

O presente artigo tem por objetivo pleitear sobre o tráfico internacional de mulheres para fins de exploração sexual. O tema é bem extenso e devido a isso será abordado apenas os pontos principais. Retratara o conceito e as causas do tráfico de pessoas. Abordando a evolução histórica do tráfico de pessoas, desde a antiguidade já era existente, uma vez que essas vítimas eram utilizadas para a escravidão, e para fins sexuais, o perfil das vítimas, que na maioria dos casos são mulheres, sendo essas, em grande parte solteira e com uma renda financeira baixa ou mínima, que vivem em comunidades carentes e desvalorizadas, sem oportunidade de educação e emprego, será esclarecido também o perfil dos aliciadores, que não é um perfil único, podendo variar entre mulheres e homens, de várias idades, e que muitas das vezes são pessoas com um bom ensino e instrução, que tem o poder de persuadir e manipular as vítimas. Será informado sobre as rotas mais utilizadas para tal ato, e por fim, será abordado sobre as leis de prevenção contra o tráfico de pessoas.