bluuebunny/crossref_metadata_2025_split huggingface dataset:
Assessing the antiviral potential of melatonin: A comprehensive systematic review
Authors: Alomari Tasneem , Al‐Abdallat Haneen , Hamamreh Rawan , Alomari Omar , Hos Beria H. , Reiter Russel J. 
Published: December 2023

AbstractThis review assesses the antiviral potential of melatonin through comprehensive analysis of studies across human subjects, animal models, cell cultures, and in‐silico simulations. The search strategy targeted relevant research until 22 June 2023, resulting in 20 primary studies after screening and deduplication. The findings highlight strong evidence supporting antiviral properties of melatonin. In silico studies identify melatonin as a candidate against SARS‐CoV‐2, reducing cytokine storm‐related respiratory responses. Cell culture experiments reveal its multifaceted effects on different viruses including respiratory syncytial virus, anti‐dengue virus, transmissible gastroenteritis virus, and encephalomyocarditis virus. Animal studies show melatonin reduces mortality and viral replication in various infections such as Venezuelan equine encephalomyelitis and COVID‐19. Clinical trials show how it could be evaluated, but with no conclusive evidence of efficacy and safety so far from large, double‐blind placebo‐controlled trials. These insights showcase the potential of melatonin as a versatile antiviral agent with immunomodulatory, antioxidant, anti‐inflammatory and antiviral properties. In summary, our review highlights melatonin's promising antiviral properties across diverse settings. Melatonin's immunomodulatory and antiviral potential makes it a compelling candidate for further investigation, emphasising the need for rigorous clinical trials to establish its safety and efficacy against viral infections.
Partially observed optimal control of local and remote controllers
Authors: Jia Hui , Ni Yuan‐Hua 
Published: December 2023

AbstractThe article investigates a networked optimal control problem with one remote controller and local controllers, where each local controller partially observes the local state and sends the observed information to remote controller through an unreliable channel and yet the channels from remote controller to local controllers are perfect. The objective of all the controllers is to cooperate to minimize a common cost function. In order to overcome the difficulties caused by partial observation of state, sufficient statistic of historical data is firstly investigated for a nonlinear non‐Gaussian partial observation model, which takes the same role as that of state in the full observation model. Then, a dynamic programming framework is given for solving the optimal control problem based on the sufficient statistic and common information approach. Furthermore, the explicit closed‐form solution is obtained for a linear‐quadratic‐Gaussian optimal control problem. Finally, a numerical example is given to show the effectiveness of the obtained results of this article.
Exploring Spherical‐Shaped Catalysts: Synthesis and Characterization for Efficient Hydrogenation of para‐Nitrophenol
Authors: As Elham Sharifi , Arsalani Nasser , Naghash‐Hamed Samin 
Published: December 2023

AbstractThis study reports the synthesis and properties of two types of nanoparticles, TiO2 and CuFe2O4, using sol‐gel and hydrothermal methods, respectively. The CuFe2O4 nanoparticles were loaded onto carbon quantum dots (CQDs) and TiO2 nanoparticles using the co‐precipitation method. Characterization of the nanoparticles and nanocomposites was carried out using FT‐IR, XRD, SEM, EDXS, PL, DRS, and UV‐Vis analyses. The FT‐IR spectra of the nanomaterials showed changes in intensity, indicating successful synthesis of the nanocomposites. The CuFe2O4@CQDs nanocomposite exhibited a distinct peak at 2θ=21° in the XRD pattern, corresponding to the diffraction of [002] planes. The CuFe2O4@CQDs nanocomposite demonstrated high activity in the hydrogenation of para‐nitrophenol (PNP) with a conversion efficiency of para‐aminophenol (PAP) of approximately 99.44 %. Its performance surpassed that of bare TiO2 and CuFe2O4 nanoparticles due to the significant effect of CQDs. The observed rate constant for the hydrogenation reaction was 0.845 (s−1), with a reduction time of 7 seconds. Moreover, the magnetic nanocatalyst was easily separated from the reaction solution and recycled for up to 6 consecutive cycles without significant loss of catalytic activity, a mere from 99.44 to 92.8 % after 6 uses. The synthesis process was straightforward and required minimal effort and time.
D−A Based 2,3‐di(pyridin‐2‐yl)pyrido[2,3‐b]pyrazine Amine derivatives as Blue‐Orange Emitting Materials: Tuning of Opto‐electrochemical and Theoretical properties
Authors: Mahadik Suraj S. , Badani Purav M. , Garud Dinesh R. , Kamble Rajesh M. 
Published: December 2023

AbstractA series of six new donor‐acceptor (D−A) type 2,3‐di(pyridin‐2‐yl)pyrido[2,3‐b]pyrazine amine derivatives as blue‐orange light emitting materials were designed, synthesized, characterized and their relevant opto‐electrochemical and theoretical properties have been fully investigated. Absorption spectra of dyes 2–7 possess intramolecular charge transfer (ICT) transitions (λmax=394–449 nm) and positive solvatochromism with emission in the blue‐orange region (λemm=477–582 nm) in solution and solid state. Further, the HOMO (−5.32 to −5.86 eV) and LUMO (−3.34 to −3.40 eV) energy levels were calculated by cyclic voltammetry (CV) and correlated by DFT/TD−DFT calculations. Moreover, computed singlet (S1) and triplet (T1) excitation energy difference (ΔEST=0.27–0.68 eV) were analyzed using the DFT/TD−DFT methods. Thus, potential applications of the dyes are proposed for organic electronics.
α‐Amylase Inhibitors Based on Thiazolidinone Skeleton: A Promising Approach in Diabetes Management
Authors: Singh Rahul , Sindhu Jayant , Kumar Parvin , Hooda Mona , Aggarwal Ranjana , Lal Sohan , Ahmadi Shahin , Lotfi Shahram , Singh Devender , Kumar Harish 
Published: December 2023

AbstractThiazolidinone scaffold has become a promising scaffold when it comes to therapeutic importance, and researchers are quite interested in it because of its wide range of applications in the different fields of chemistry. The capacity of this nucleus to interact with a variety of biological targets, including the peroxisome proliferator‐activated receptor (PPAR), protein tyrosine phosphatase 1B, aldose reductase, α‐glucosidase, and α‐amylase, has led to the observation of its antidiabetic effect. α‐Amylase (α‐1,4‐glucan‐4‐glucanohydrolase, EC 3.2.1.1) is one of the most important industrial endoamylases capable of hydrolyzing the internal α‐1,4‐glycosidic bonds in polysaccharides with net retention of α‐anomeric configuration in low molecular weight products, such as glucose, maltose, and maltotriose units. The inhibitors of α‐amylase have the ability to lower endogenous activity, which is crucial for the management of agricultural pests as well as the treatment and prevention of human disorders. In the present review, we attempted to compile the most recent studies on thiazolidinone‐based α‐amylase inhibitors, investigate their therapeutic potential in treating diabetes, comprehend the relationships between structure and activity, offer suggestions for future research and translation of these findings into clinical applications. This comprehensive review strives to be a valuable resource for researchers, medicinal chemists, and healthcare professionals involved in developing and applying novel therapeutics for treating metabolic disorders.
New Pyrazole‐Hydrazide Derivatives: Synthesis, Characterization, Highly Active Catecholase‐Like Catalyst, and Antibacterial Study
Authors: Roby Othmane , Ouadghiri Zaynab , Moutaouakil Mohamed , Alzahran Abdullah Y. , Loukhmi Zineb , Saddik Rafik , Mtairag El Mostafa , Aboulmouhajir Aziz , Tighadouini Said 
Published: December 2023

AbstractThis captivating presents a detailed exploration of novel pyrazole‐hydrazide derivatives achieved through meticulous synthesis and characterization. A series of novel compounds were synthesized and characterized using a variety of spectroscopic techniques and hyphenated techniques, confirming their structures and purities with precision. Intriguingly, the combination of these synthesized pyrazole‐hydrazide derivatives ligands and copper (II) salts such as Cu(CH3COO)2, Cu(NO3)2, CuSO4, and CuCl2 at aerobic conditions demonstrated remarkable efficiency in catalyzing the oxidation of catechol to o‐quinone. Particularly noteworthy is the excellent rate of 401 μmol L−1 s−1 exhibited by the complex formed by ligand L6 and the metal salt Cu(CH3COO)2 in the oxidation of catechol to o‐quinone. Additionally, an investigation into the antibacterial activity of these compounds against diverse bacterial strains, including Escherichia coli, Pseudomonas aeruginosa, and Staphylococcus aureus, was conducted. Surprisingly, the results revealed a distinct absence of significant antibacterial efficacy in the tested pyrazole‐hydrazide derivatives. This study contributes to the understanding of pyrazole‐hydrazide derivatives, emphasizing their catalytic potential. The novel compounds presented herein can serve as a starting point for applications in various fields, thereby enriching the research and paving the way for future investigations.
Advanced Interface Engineering in Gradient Core/Shell Quantum Dots Enables Efficient Photoelectrochemical Hydrogen Evolution
Authors: Zhang Hui , Liu Jiabin , Besteiro Lucas V. , Selopal Gurpreet S. , Zhao Zhenhuan , Sun Shuhui , Rosei Federico 
Published: December 2023

AbstractSemiconductor core/shell quantum dots (QDs) are considered promising building blocks to fabricate photoelectrochemical (PEC) cells for the direct conversion of solar energy into hydrogen (H2). However, the lattice mismatch between core and shell in such QDs results in undesirable defects and severe carrier recombination, limiting photo‐induced carrier separation/transfer and solar‐to‐fuel conversion efficiency. Here, an interface engineering approach is explored to minimize the core‐shell lattice mismatch in CdS/CdSexS1‐x (x = 0.09–1) core/shell QDs (g‐CSG). As a proof‐of‐concept, PEC cells based on g‐CSG QDs yield a remarkable photocurrent density of 13.1 mA cm−2 under AM 1.5 G one‐sun illumination (100 mW cm−2), which is ≈54.1% and ≈33.7% higher compared to that in CdS/CdSe0.5S0.5 (g‐CSA) and CdS/CdSe QDs (g‐CS), respectively. Theoretical calculations and carrier dynamics confirm more efficient carrier separation and charge transfer rate in g‐CSG QDs with respect to g‐CSA and g‐CS QDs. These results are attributed to the minimization of the core‐shell lattice mismatch by the cascade gradient shell in g‐CSG QDs, which modifies carrier confinement potential and reduces interfacial defects. This work provides fundamental insights into the interface engineering of core/shell QDs and may open up new avenues to boost the performance of PEC cells for H2 evolution and other QDs‐based optoelectronic devices.
Metal–Organic Framework as a New Type of Magnetothermally‐Triggered On‐Demand Release Carrier
Authors: Ge Xueying , Mohapatra Jeotikanta , Silva Enya , He Guihua , Gong Lingshan , Lyu Tengteng , Madhogaria Richa P. , Zhao Xin , Cheng Yuchuan , Al‐Enizi Abdullah M. , Nafady Ayman , Tian Jian , Liu J. Ping , Phan Manh‐Huong , Taraballi Francesca , Pettigrew Roderic I. , Ma Shengqian 
Published: December 2023

AbstractThe development of external stimuli‐controlled payload systems has been sought after with increasing interest toward magnetothermally‐triggered drug release (MTDR) carriers due to their non‐invasive features. However, current MTDR carriers present several limitations, such as poor heating efficiency caused by the aggregation of iron oxide nanoparticles (IONPs) or the presence of antiferromagnetic phases which affect their efficiency. Herein, a novel MTDR carrier is developed using a controlled encapsulation method that fully fixes and confines IONPs of various sizes within the metal–organic frameworks (MOFs). This novel carrier preserves the MOF's morphology, porosity, and IONP segregation, while enhances heating efficiency through the oxidation of antiferromagnetic phases in IONPs during encapsulation. It also features a magnetothermally‐responsive nanobrush that is stimulated by an alternating magnetic field to enable on‐demand drug release. The novel carrier shows improved heating, which has potential applications as contrast agents and for combined chemo and magnetic hyperthermia therapy. It holds a great promise for magneto‐thermally modulated drug dosing at tumor sites, making it an exciting avenue for cancer treatment.
Manganese‐Doped Bimetallic (Co,Ni)2P Integrated CoP in N,S Co−Doped Carbon: Unveiling a Compatible Hybrid Electrocatalyst for Overall Water Splitting
Authors: Kandel Mani Ram , Pan Uday Narayan , Dhakal Purna Prasad , Ghising Ram Babu , Sidra Saleem , Kim Do Hwan , Kim Nam Hoon , Lee Joong Hee 
Published: December 2023

AbstractRational design of highly efficient noble‐metal‐unbound electrodes for hydrogen and oxygen production at increased current density is crucial for robust water‐splitting. A facile hydrothermal and room‐temperature aging method is presented, followed by chemical vapor deposition (CVD), to create a self‐sacrificed hybrid heterostructure electrocatalyst. This hybrid material, (Mn−(Co,Ni)2P/CoP/(N,S)−C), comprises manganese‐doped cobalt nickel phosphide (Mn−(Co,Ni)2P) nanofeathers and cobalt phosphide (CoP) nanocubes embedded in a nitrogen and sulfur co‐doped carbon matrix (N,S)−C on nickel foam. The catalyst exhibits excellent performance in both the hydrogen evolution reaction (HER; η10 = 61 mV) and oxygen evolution reaction (OER; η10 = 213 mV) due to abundant active sites, high porosity, and enhanced hetero‐interface interaction between Mn−(Co2P−Ni2P) CoP, and (N,S)−C supported by significant synergistic effects observed among different phases through density functional theory (DFT) calculations. Impressively, (Mn−(Co,Ni)2P/CoP/(N,S)−C (+,−) shows an extra low cell voltage of 1.49 V@10 mA cm−2. Moreover, the catalyst exhibits remarkable stability at 100 and 300 mA cm−2 when operating as a single stack cell electrolyzer. The superior electrochemical activity is attributed to the enhanced electrode–electrolyte interface among the multiple phases of the hybrid structure.
From Sheep Track to Motorway: Supramolecular‐Mediated 2D Nanofluidic Channels for Ultrafast Water Transport
Authors: Zhu Bo , Guo Changsheng , Li Nan , Liu Pengbi , Zhang Mengchen , Wang Lijing , Xu Zhiwei 
Published: December 2023

AbstractAtomic thick 2D materials hold great potential as building blocks to construct highly permeable membranes, yet the permeability of laminar 2D material membranes is still limited by their irregularity sheep track‐like interlayer channels. Herein, a supramolecular‐mediated strategy to induce the regular assembly of high‐throughput 2D nanofluidic channels based on host–guest interactions is proposed. Inspired by the characteristics of motorways, supramolecular‐mediated ultrathin 2D membranes with broad and continuous regular water transport channels are successfully constructed using graphene oxide (GO) as an example. The prepared membrane achieves an ultrahigh water permeability (369.94 LMH bar−1) more than six times higher than that of the original membranes while maintaining dye rejection above 98.5%, which outperforms the reported 2D membranes. Characterization and simulation results show that the introduction of hyaluronate‐grafted β‐cyclodextrin not only expands the interlayer channels of GO membranes but also enables the membranes to operate stably under harsh conditions with the help of host–guest interactions. This universal supramolecular assembly strategy provides new opportunities for the preparation of 2D membranes with high separation performance and reliable and stable nanofluidic channels.
Compressive Strain in Platinum–Iridium–Nickel Zigzag‐Like Nanowire Boosts Hydrogen Catalysis
Authors: Wang Mingmin , Tang Chongyang , Geng Shize , Zhan Changhong , Wang Liyuan , Huang Wei‐Hsiang , Pao Chih‐Wen , Hu Zhiwei , Li Yunhua , Huang Xiaoqing , Bu Lingzheng 
Published: December 2023

AbstractStrain effect in the structurally defective materials can contribute to the catalysis optimization. However, it is challenging to achieve the performance improvement by strain modulation with the help of geometrical structure because strain is spatially dependent. Here, a new class of compressively strained platinum–iridium‐metal zigzag‐like nanowires (PtIrM ZNWs, M = nickel (Ni), cobalt (Co), iron (Fe), zinc (Zn) and gallium (Ga)) is reported as the efficient alkaline hydrogen evolution reaction (HER) and hydrogen oxidation reaction (HOR) catalysts. Particularly, the optimized PtIrNi ZNWs with 3% compressive strain (cs‐PtIrNi ZNWs) can achieve the highest HER/HOR performances among all the catalysts investigate. Their HOR mass and specific activities are 3.2/14.4 and 2.6/32.7 times larger than those of PtIrNi NWs and commercial Pt/C, respectively. Simultaneously, they can exhibit the superior stability and high CO resistance for HOR. Further, experimental and theoretical studies collectively reveal that the compressive strain in cs‐PtIrNi ZNWs effectively weakens the adsorption of hydroxyl intermediate and modulates the electronic structure, resulting in the weakened hydrogen binding energy (HBE) and moderate hydroxide binding energy (OHBE), beneficial for the improvement of HOR performance. This work highlights the importance of strain tuning in enhancing Pt‐based nanomaterials for hydrogen catalysis and beyond.
A Short‐Range Ordered α‐MoO3 with Modulated Interlayer Structure via Hydrogen Bond Chemistry for NH4+ Storage
Authors: Liu Huan , Zhang Kuixuan , Wang Shulan , Cai Xiang 
Published: December 2023

AbstractThe layered orthorhombic molybdenum trioxide (α‐MoO3) is a promising host material for NH4+ storage. But its electrochemical performances are still unsatisfactory due to the absence of fundamental understanding on the relationship between structure and property. Herein, NH4+ storage properties of α‐MoO3 are elaborately studied. Electrochemistry together with ex situ physical characterizations uncover that irreversible H+/NH4+ co‐intercalation in the initial cycle confines the electrochemically reactive domain to the near surface of α‐MoO3 thus resulting in a low reversible NH4+ storage capacity. This issue can be resolved by decreasing ion diffusion pathway to construct short‐range ordered α‐MoO3 (SMO), which improves the specific capacity to 185 mAh g−1. SMO suffers from dissolution issue. In view of this the interlayer structure of SMO is reconstructed via hydrogen bond chemistry to reinforce the structural stability and it is discovered that the hydrogen bond network only with moderate intensity endows SMO with both high capacity and ability against dissolution. This work presents a new avenue to improve the NH4+ storage properties of α‐MoO3 and highlights the important role of hydrogen bond intensity in optimizing electrochemical properties.
Tumor Microenvironment‐Specific Driven Nanoagents for Synergistic Mitochondria Damage‐Related Immunogenic Cell Death and Alleviated Immunosuppression
Authors: Qian Yanrong , Chen Weilin , Wang Man , Xie Yulin , Qiao Luying , Sun Qianqian , Gao Minghong , Li Chunxia 
Published: December 2023

AbstractDespite significant breakthroughs in immunotherapy, the limitations of inadequate immune stimulation and stubborn immune resistance continue to present opportunities and challenges. Therefore, a two‐pronged approach, encompassing the activation of immunogenic cell death (ICD) and blocking the indoleamine 2,3‐dioxygenase (IDO)‐mediated pathway, is devised to elicit systemic anti‐tumor immunity and alleviate immunosuppression. Herein, a tumor microenvironment (TME)‐specific driven nanoagent is composed of a tetrasulfide bond‐bridged mesoporous silica layer (MON) coated up‐conversion nanoparticles as a nano‐carrier, combines Fe2+, curcumin, and indoximod for operating chemodynamic therapy/chemotherapy/immunotherapy. The consumption of glutathione (GSH) caused by MON degradation, the Fenton reaction of Fe2+, and curcumin triggering mitochondrial damage collectively exacerbate the oxidative stress, leading to a violent immunoreaction and reversal of the immunosuppressive TME through a combination of IDO‐inhibitors. Meanwhile, upconversion luminescence (UCL) imaging serves as a significant guiding tool for drug delivery and the treatment of nanoagents. In vivo and in vitro experiment results demonstrate that the nanosystem not only effectively inhibits the growth of primary tumors but also induces immune priming and memory effects to reject re‐challenged tumors. The strategy as a complementary approach displays great potential for future immunotherapy along with other multimodal treatment modes.
Development of Air‐Cooled Carbide‐Free Bainite/Martensite Multiphase Steel: Transformation Kinetics, Microstructure, and Mechanical Properties
Authors: Cheng Xuan , Gao Guhui , Liu Rong , Gui Xiaolu , Bai Bingzhe , Feng Chun 
Published: December 2023

An air‐cooled low‐carbon Mn–Si–Cr alloyed steel with multiphase microstructure of carbide‐free bainite/martensite (CFB/M) is developed. The kinetics of bainitic transformation during air‐cooling process is discussed via considering the transformation latent heat with help of the measured temperature‐cooling curves. Results show that the CFB formed during air cooling can effectively refine the multiphase microstructure and stabilize the film‐like retained austenite that contributes to transformation‐induced plasticity effect upon deformation. An optimum combination of strength, ductility, and toughness of the air‐cooled bainitic steel is achieved (tensile strength: 1418 MPa, total elongation: 15.8%, and Charpy V‐notch impact energy: ≈71 J). The newly developed Mn–Si–Cr alloyed air‐cooled bainitic steel exhibits superior mechanical properties to the commercial 23CrNi3Mo steel but has a much lower alloy cost.
Multiplexed transcriptional profiling of Dermatophagoides house dust mites allergens in human epithelium cells
Authors: Lin Chia‐Yang , Cheng Chun‐Wen , Ko Jiunn‐Liang , Lue Ko‐Huang , Liu Yu‐Fan 
Published: December 2023

AbstractAllergic asthma, a chronic disease characterized by airway inflammation, poses a significant public health concern. It is well‐established that house dust mites (HDMs) are common inducers of allergic responses in individuals, particularly children. In central Taiwan, our research team observed that over 80% of allergic children exhibited sensitization to various HDMs species. This investigation aims to bridge the gap between these observations and a better understanding of the early fundamental mechanisms for preventing allergic diseases. Specifically, our study delves into the impact of crude extracts of HDMs on human epithelial BEAS‐2B cells. Our findings, based on RNA sequencing (RNA‐seq) analysis, shed light on how three major Dermatophagoides HDMs allergens activate a common Toll‐like receptor signaling pathway in human epithelial cells within a 4‐h treatment. During this process, the nuclear transcription factor NF‐κB translocated into the cell nucleus within 30 min of allergen stimulation, triggering the expression of pro‐inflammatory genes such as IL‐6 and IL‐8 over 4 h. Additionally, when the cells were treated with specific Dermatophagoides microceras (Der m) allergens, it resulted in the upregulation of genes that regulate type 1 diabetes mellitus (T1DM) signaling pathways. This led to the mediation of IL‐12A inflammation. Furthermore, there was an increase in gene sets associated with cilia function and the microtubule cytoskeleton in human epithelial cells after treatment with a combination of Der m allergens and Dexamethasone. Additionally, OMICs analysis was conducted to examine the effects of HDMs allergenic stimulation on human epidermal cells. We aimed to improve our understanding of the molecular mechanisms within cells and identify potential targets and natural products in the treatment of asthma caused by HDMs allergens.