bluuebunny/crossref_metadata_2025_split huggingface dataset:
In person versus remote cognitive rehabilitation in patients with subjective cognitive decline or neurocognitive disorders: what factors drive patient’s preference?
Authors: Bernini Sara , Ballante Elena , Fassio Federico , Panzarasa Silvia , Quaglini Silvana , Riccietti Chiara , Costa Alfredo , Cappa Stefano F. , Tassorelli Cristina , Vecchi Tomaso , Bottiroli Sara 
Published: October 2023

BackgroundTo date, there is still a lack of consensus for identifying the ideal candidate for cognitive telerehabilitation (TR). The main goal of the present study is to identify the factors associated to the preference for either TR or in-person cognitive training (CT) programs in older adults at risk of dementia or with early cognitive impairment.MethodsA sample of 56 participants with subjective cognitive decline or neurocognitive disorders eligible for CT were enrolled at the Dementia Research Center and Neurorehabilitation Unit of IRCCS Mondino Foundation. All individuals underwent a baseline assessment to capture their complete profile, including cognitive reserve and lifestyle habits, sociodemographic characteristics, cognitive functioning, and mental health. Patients were then asked their preference for TR or in-person CT, before being randomized to either treatment as per protocol procedures. Statistical analyses included explorative descriptive approach, logistic regression, and non-parametric models to explore the overall contribution of each variable.ResultsThe two (TR and in-person) preference groups were similar for cognitive functioning and mental health status. Socio-demographic and lifestyle profiles seem to be the most important factors to influence the preference in terms of the area under the curve (AUC) of the models. The two preference groups differed in terms of socio-demographic characteristics (e.g., level of technological skills, age, and distance from the clinic). Furthermore, participants who selected the TR modality of CT had significantly higher levels of cognitive reserve and adopted more protective lifestyle habits (e.g., regular physical activity, Mediterranean diet) when compared to those who preferred in-person CT.DiscussionThese findings highlight that the preference to receive CT delivered by TR or in person is a complex issue and is influenced by a variety of factors, mostly related to lifestyle habits and sociodemographic characteristics. Availability of profiles of patients that may be more attracted to one or the other modality of TR may help promote shared decision-making to enhance patient experience and outcomes.
The acceptability, feasibility, and preliminary efficacy of a supported online self-help treatment program for binge-eating disorder
Authors: Rom Sean , Miskovic-Wheatley Jane , Barakat Sarah , Aouad Phillip , Kim Marcellinus , Fuller-Tyszkiewicz Matthew , Maguire Sarah 
Published: October 2023

IntroductionStudies in transdiagnostic eating disorder (ED) samples suggest supported online self-help programs (eTherapies) are effective and may improve access to treatment; however, their evaluation in those with binge-eating disorder (BED) is limited. Given BED’s high prevalence and low levels of treatment uptake, further eTherapy evaluation is needed to broaden access to effective, evidence-based treatment options. The aim of this study was to investigate the acceptability, feasibility, and preliminary efficacy of a supported eTherapy for those with BED or subthreshold BED, and to examine symptom change across the duration of therapy.MethodNineteen women with BED completed a supported, 10-session Cognitive Behavioural Therapy-based eTherapy in an uncontrolled, pre-post, and 3 months follow up intervention study. Key outcomes were assessed by the Eating Disorder Examination Questionnaire (EDE-Q): objective binge episode (OBE) frequency and ED psychopathology. Feasibility was evaluated via program adherence and dropout, whilst acceptability was assessed through participant feedback post-treatment. Weekly symptom change (ED psychopathology) during treatment was assessed by the Eating Disorder Examination - Questionnaire Short (EDE-QS).ResultsGeneralised estimating equations showed statistically and clinically significant reductions in OBEs and ED psychopathology (large effects) post-treatment, with these decreases maintained at follow up. Across weekly assessment, a marked slowing in the rate of change in ED psychopathology was observed after four sessions of the program. Program feasibility was high (i.e., 84% of content completed), as was program acceptability (i.e., 93% of participants expressed high levels of satisfaction).DiscussionThese results support the acceptability, feasibility, and preliminary efficacy of a supported eTherapy program for those with BED and suggest the variability of symptom change across the duration of therapy. Future research should further investigate findings in an adequately powered randomised controlled trial.
The continuum of care as a unifying framework for intergenerational and interspecies health equity
Authors: Stephen Craig , Walzer Chris 
Published: October 2023

IntroductionUnlocking the full potential of different people and organizations to address existential health threats requires shared goals and frameworks that allow people to see themselves contributing to a common and shared continuum of care. A new narrative to help people implement collective action for collective problems is needed.MethodsThis paper is draw from the co-authors experience working from the local to international level on planetary health problems.ResultsThe proposed conceptual framework expands the socioecological model of health to help formulate multilevel approaches that foster healthier circumstances for all by revealing the mutual benefits that emerge from pooling expertise, funding, and political will to solve multiple problems with coordinated investment of resources and effort. It is intended to support program planning and communication. This framework is a response to the absence of systematic attempts to concurrently counteract the social and environmental conditions leading to disease, dysfunction and deficits which is increasingly seen as being problematic, especially as the root causes of health problems and solutions converge across species, sectors, and generations. The framework is embedded in the idea of interspecies and intergenerational health equity.DiscussionEnsuring interspecies and intergenerational health equity requires each actor to fulfill their roles along the continuum while supporting the needs of others. A socio-ecological continuum of care provides bundled options that combine knowledge from different sectors, disciplines and perspectives to guide interventions over time across a comprehensive array of services and support spanning all levels of needs, species and generations.
Community organization perspectives on COVID-19 vaccine hesitancy and how they increased COVID-19 vaccine confidence: a Canadian Immunization Research Network, social sciences and humanities network study
Authors: Ashfield Sarah , Donelle Lorie , Uppal Gina , Bauer Michael A. , Kothari Anita 
Published: October 2023

BackgroundCOVID-19 vaccines play a critical role in reducing the morbidity and mortality associated with SARS-CoV-2 infection and despite vaccine availability, disparities in COVID-19 vaccine uptake among Canadian subgroups exist. Community organizations are uniquely situated to relay important vaccine messaging around all vaccines, understand components of vaccine hesitancy, and facilitate vaccine uptake within the communities they serve. The objective of this research was to solicit community organizations perspectives specific to COVID-19 vaccines and explore strategies of increasing vaccine uptake within their communities.MethodsA qualitative focus group study was held in the spring of 2021 with 40 community organizations from across the country. Discussions focused on COVID-19 vaccine communication and awareness within their communities, vaccine misinformation, and strategies to increase vaccine acceptance and access. Data were analyzed utilizing thematic and inductive techniques.ResultsVaccine hesitancy was identified among staff and clients. Vaccine confidence, complacency, convenience, and mistrust in government and authorities were identified as contributors to vaccine hesitancy. Community organizations utilized innovative and novel methods to encourage vaccine uptake and increase vaccine confidence. Leveraging established trusting relationships was key to successful messaging within communities.ConclusionCommunity organizations used innovative methods, built on established trust, to increase vaccine confidence within their communities and among their staff. Community agencies played an important role in COVID-19 vaccine uptake within subgroups of the Canadian population. Community organizations are key public health partners and play a critical role in increasing COVID-19 vaccine confidence.
Micro-costing analysis of suspected lower respiratory tract infection care in a French emergency department
Authors: Wilmé Valérie , Sauleau Érik-André , Le Borgne Pierrick , Bayle Éric , Bilbault Pascal , Kepka Sabrina 
Published: October 2023

IntroductionIn the context of budgetary constraints faced by healthcare systems, the medical-economic evaluation of care strategies becomes essential. In particular, valuing consumed resources in the overcrowded emergency departments (EDs) has become a priority to adopt more efficient approaches in treating the growing number of patients. However, precisely measuring the cost of care is challenging. While bottom-up micro-costing is considered the gold standard, its practical application remains limited.ObjectiveThe objective was to accurately estimate the ED care cost for patients consulting in a French ED for suspected lower respiratory tract infection.MethodsThe authors conducted a cost analysis using a bottom-up micro-costing method. Patients were prospectively included between January 1, and March 31, 2023. The primary endpoint was the mean cost of ED care. Resources consumed were collected using direct observation method and cost data were obtained from information available at Strasbourg University Hospital.ResultsThe mean cost of ED care was €411.68 (SD = 174.49). The cost elements that made the greatest contribution to the total cost were laboratory tests, labor, latency time, imaging and consumables. Considering this cost and the current epidemiological data on respiratory infections in France, the absence of valuation for outpatient care represents an annual loss of over 17 million euros for healthcare facilities.ConclusionMicro-costing is a key element in valuing healthcare costs. The importance of accurately measuring costs, along with measuring the health outcomes of a defined care pathway, is to enhance the relevance of health economic evaluations and thus ensure efficient care.
Cannabidiol plasma determination and pharmacokinetics conducted at beginning, middle and end of long-term supplementation of a broad-spectrum hemp oil to healthy adult dogs
Authors: Corsato Alvarenga Isabella , Gustafson Daniel , Banks Krista , Wilson Kim , McGrath Stephanie 
Published: October 2023

IntroductionVeterinary hemp products containing cannabidiol (CBD) and negligible psychoactive (THC) have increased popularity since hemp (with &lt;0.3% THC) was removed from schedule 1 substances under the Controlled Substances Act in 2018. This was accompanied by increased CBD research, mostly on the short-term safety and efficacy for inflammatory and neurological conditions. It is imperative to understand how CBD is metabolized or accumulated in the body long-term, thus the goal of the present work was to determine monthly plasma CBD concentrations, as well as changes in pharmacokinetic (PK) parameters in chronically dosed dogs.MethodsThe study was a masked, placebo-controlled, randomized design. Six adult beagles were assigned to placebo, 5 and 10 mg/kg/day CBD treatment groups. Dogs received oral oil treatment once daily for 36 weeks. Blood was collected once every 4 weeks pre- and postprandially for CBD plasma determination (at 0 and 2 h). Pharmacokinetics were conducted at 0, 18 and 36 weeks. Pharmacokinetics and monthly CBD plasma data of dogs who received CBD were analyzed as repeated measures over time using a mixed model, with significance atα = 0.05.ResultsAverage plasma CBD at 5 and 10 mg/kg were 97.3 ng/mL and 236.8 ng/mL pre-prandial, 341 ng/mL and 1,068 ng/mL postprandial, respectively. PK parameters suggested CBD accumulation over time, with significant increases in Cmaxand AUC at both the 18 and 36-week timepoints. Cmaxand AUC were dose proportional. Half-life demonstrated large inter-individual variations and increased (p &lt; 0.05) at weeks 18 and 36 compared to baseline. Volume of distribution was not affected by time or treatment, while MRT increased, and clearance decreased over time (p &lt; 0.05).Conclusions and clinical importanceChronic administration of CBD to healthy adult dogs led to a dose-proportional accumulation in the body for 36 weeks, which was confirmed by an increased half-life, total exposure, mean residence time and plasma peak. Our data also suggests that CBD plasma levels may have less daily variation if administered twice daily.
Analysis of miRNAs in Osteogenesis imperfecta Caused by Mutations in COL1A1 and COL1A2: Insights into Molecular Mechanisms and Potential Therapeutic Targets
Authors: Botor Malwina , Auguściak-Duma Aleksandra , Lesiak Marta , Sieroń Łukasz , Dziedzic-Kowalska Agata , Witecka Joanna , Asman Marek , Madetko-Talowska Anna , Bik-Multanowski Mirosław , Galicka Anna , Sieroń Aleksander L. , Gawron Katarzyna 
Published: October 2023

Osteogenesis imperfecta (OI) is a group of connective tissue disorders leading to abnormal bone formation, mainly due to mutations in genes encoding collagen type I (Col I). Osteogenesis is regulated by a number of molecules, including microRNAs (miRNAs), indicating their potential as targets for OI therapy. The goal of this study was to identify and analyze the expression profiles of miRNAs involved in bone extracellular matrix (ECM) regulation in patients diagnosed with OI type I caused by mutations in COL1A1 or COL1A2. Primary skin fibroblast cultures were used for DNA purification and sequence analysis, followed by analysis of miRNA expression. Sequencing analysis revealed mutations of the COL1A1 or COL1A2 genes in all OI patients, including four previously unreported. Amongst the 40 miRNAs analyzed, 9 were identified exclusively in OI cells and 26 in both OI patients and the controls. In the latter case, the expression of six miRNAs (hsa-miR-10b-5p, hsa-miR-19a-3p, hsa-miR-19b-3p, has-miR-204-5p, has-miR-216a-5p, and hsa-miR-449a) increased, while four (hsa-miR-129-5p, hsa-miR-199b-5p, hsa-miR-664a-5p, and hsa-miR-30a-5p) decreased significantly in OI cells in comparison to their expression in the control cells. The identified mutations and miRNA expression profiles shed light on the intricate processes governing bone formation and ECM regulation, paving the way for further research and potential therapeutic advancements in OI and other genetic diseases related to bone abnormality management.
Satisfaction with remote consultations in primary care during COVID-19: a population survey of UK adults
Authors: Lifford Kate J , Grozeva Detelina , Cannings-John Rebecca , Quinn-Scoggins Harriet , Moriarty Yvonne , Gjini Ardiana , Goddard Mark , Hepburn Julie , Hughes Jacqueline , Moore Graham , Osborne Kirstie , Robling Michael , Townson Julia , Waller Jo , Whitelock Victoria , Whitaker Katriina L , Brain Kate 
Published: October 2023

BackgroundMode of access to primary care changed during the COVID-19 pandemic; remote consultations became more widespread. With remote consultations likely to continue in UK primary care, it is important to understand people’s perceptions of remote consultations and identify potential resulting inequalities.AimTo assess satisfaction with remote GP consultations in the UK during the COVID-19 pandemic and identify demographic variation in satisfaction levels.Design and settingA cross-sectional survey from the second phase of a large UK-based study, which was conducted during the COVID-19 pandemic.MethodIn total, 1426 adults who self-reported having sought help from their doctor in the past 6 months completed an online questionnaire (February to March 2021). Items included satisfaction with remote consultations and demographic variables. Associations were analysed using multivariable regression.ResultsA novel six-item scale of satisfaction with remote GP consultations had good psychometric properties. Participants with higher levels of education had significantly greater satisfaction with remote consultations than participants with mid-level qualifications (B= −0.82, 95% confidence interval [CI] = −1.41 to −0.23) or those with low or no qualifications (B= −1.65, 95% CI = −2.29 to −1.02). People living in Wales reported significantly higher satisfaction compared with those living in Scotland (B= −1.94, 95% CI = −3.11 to −0.78), although caution is warranted due to small group numbers.ConclusionThese findings can inform the use and adaptation of remote consultations in primary care. Adults with lower educational levels may need additional support to improve their experience and ensure equitable care via remote consultations.
Long-term consequences of urinary tract infection in childhood: an electronic population-based cohort study in Welsh primary and secondary care
Authors: Hughes Kathryn , Cannings-John Rebecca , Jones Hywel , Lugg-Widger Fiona , Lau Tin Man Mandy , Paranjothy Shantini , Francis Nick , Hay Alastair D , Butler Christopher C , Angel Lianna , Van der Voort Judith , Hood Kerenza 
Published: October 2023

BackgroundChildhood urinary tract infection (UTI) can cause renal scarring, and possibly hypertension, chronic kidney disease (CKD), and end-stage renal failure (ESRF). Previous studies have focused on selected populations, with severe illness or underlying risk factors. The risk for most children with UTI is unclear.AimTo examine the association between childhood UTI and outcomes in an unselected population of children.Design and settingA retrospective population-based cohort study using linked GP, hospital, and microbiology records in Wales, UK.MethodParticipants were all children born in 2005–2009, with follow-up until 31 December 2017. The exposure was microbiologically confirmed UTI before the age of 5 years. The key outcome measures were renal scarring, hypertension, CKD, and ESRF.ResultsIn total, 159 201 children were included; 77 524 (48.7%) were female and 7% (n= 11 099) had UTI before the age of 5 years. A total of 0.16% (n= 245) were diagnosed with renal scarring by the age of 7 years. Odds of renal scarring were higher in children by age 7 years with UTI (1.24%; adjusted odds ratio 4.60 [95% confidence interval [CI] = 3.33 to 6.35]). Mean follow-up was 9.53 years. Adjusted hazard ratios were: 1.44 (95% CI = 0.84 to 2.46) for hypertension; 1.67 (95% CI = 0.85 to 3.31) for CKD; and 1.16 (95% CI = 0.56 to 2.37) for ESRF.ConclusionThe prevalence of renal scarring in an unselected population of children with UTI is low. Without underlying risk factors, UTI is not associated with CKD, hypertension, or ESRF by the age of 10 years. Further research with systematic scanning of children’s kidneys, including those with less severe UTI and without UTI, is needed to increase the certainty of these results, as most children are not scanned. Longer follow-up is needed to establish if UTI, without additional risk factors, is associated with hypertension, CKD, or ESRF later in life.
Réorientation des échanges et horizontalité structurelle : une analyse à partir des tableaux d’échanges interindustriels
Authors: Byé Pascal , Frey Jean-Pierre 
Published: October 2023

Cet article poursuit un double objectif :
• insister sur la pertinence des approches méso-économiques fondées sur le traitement des tableaux entrées-sorties pour mettre en lumière la réorientation des échanges dans le complexe agro-industriel à l'intérieur de blocs d'industries cohérents ;
• utiliser les résultats obtenus pour approfondir l'analyse du passage de la verticalité à l' horizontalité des échanges dans ce système productif particulier.
Structure des buts du consommateur et schémas de substituabilité perçue : application à l’étude de la situation du vin dans l’univers des boissons
Authors: Aurier Philippe 
Published: October 2023

Dans cet article, nous nous intéressons à la situation d’un produit (le vin) en le plaçant dans son contexte de consommation au sens large (l’univers des boissons). Pour identifier et comprendre cet univers nous utilisons le concept de situation d’usage qui nous permet de définir le marché, au plan individuel (par opposition à agrégé) et perçu (par opposition à comportement ), comme étant l’ensemble de considérations du consommateur résultant d’un processus de catégorisation par les buts. Nous proposons un schéma conceptuel définissant la substituabilité comme l'appartenance simultanée de deux produits au même ensemble de considérations. Celle-ci est déterminée par confrontation entre les bénéfices désirés pour le contexte envisagé et les bénéfices offerts par le produit.
Un résultat important de la recherche est la caractérisation d’une hiérarchie stable de buts (contextes de consommation) qui conditionnent les attentes des consommateurs et leurs jugements de substituabilité. Nous en déduisons un diagnostic global sur les structures de substituabilité des produits pour cinq familles de contextes de consommation et formulons des recommandations stratégiques pour le vin.
Well-ordered molecular heterojunction of epitaxial C60 on single-crystal dinaphtho[2,3-b:2′,3′-f]thieno[3,2-b]thiophene (DNTT)
Authors: Nakayama Yasuo , Ito Kosei , Takeuchi Riku , Tsuruta Ryohei , Yamauchi Kaname , Izawa Seiichiro , Hiramoto Masahiro , Kumara Rosantha , Koganezawa Tomoyuki 
Published: October 2023

Abstract
A well-ordered molecular arrangement is a necessary condition for “band transport” in molecular semiconductor materials, and thus it is important for donor–acceptor molecular junctions for applications in advanced organic optoelectronic devices. In this study, the heteroepitaxial growth of an acceptor material C60 on a single-crystal (001) surface of dinaphtho[2,3-b:2′,3′-f]thieno[3,2-b]thiophene (DNTT), a representative high-mobility donor material, is demonstrated. Surface X-ray diffraction analysis indicated spontaneous alignment of the nearest-neighbor molecular direction of the C60 crystallites uniquely to the
a
-axis of the DNTT.