bluuebunny/crossref_metadata_2025_split huggingface dataset:
Endorsement of metaphysical idealism mediates a link between past use of psychedelics and wellbeing
Authors: Jylkkä Jussi , Krabbe Andreas , Jern Patrick 
Published: February 2024

Abstract

It has been proposed that psychedelics promote wellbeing through spiritual-type transformations, involving changes in metaphysical beliefs. Past empirical research shows a link between the use of psychedelics and the endorsement of non-physicalist metaphysical beliefs. However, non-physicalist beliefs encompass a wide range of metaphysical ideas, and their links to wellbeing and psychedelics use remain unclear. We utilized a cross-sectional Internet survey to probe the metaphysical beliefs of participants (N = 701) with past experience of classical psychedelics, using a novel 42-item questionnaire (Core Metaphysical Beliefs, CMB), encompassing a wide range of metaphysical beliefs. Factor analysis of CMB revealed two factors, Idealism and Materialism. In network analyses, Idealism was linked to psychological insight in a past psychedelic experience (E = .24) and average use of psychedelics (E = .17), and predicted wellbeing (Es = .12 and .17). Mediation analyses showed an indirect link from past psychedelics use through Idealism to wellbeing (ps ≤ .006). Non-Physicalist Beliefs or Materialism were not significant mediators. The results indicate that Idealism specifically, not non-physicalist beliefs generally, mediate a link between the use of psychedelics and wellbeing. Future research is required to establish whether the link is causal, and to understand what the Idealism factor means.
The "tonifying the kidneys, resolving blood stasis and clearing collaterals" method in polycystic ovary syndrome (PCOS) research: study protocol for a multicentre cohort study nested randomised controlled trials
Authors: Song Rui , liu yonghui , Yang Dongyan , Li Na , Xu Hua , Jiao Kailin , Xiao Yang , Zhu Haihui , Sun Lianqing , Wang Rui 
Published: February 2024

Abstract
Introduction: Polycystic ovary syndrome (PCOS) presents as a multi-complicated syndrome and increases the risk of other diseases. Life management is clinically ineffective as a first-line basic treatment for polycystic ovary syndrome. Acupuncture and Chinese herbal medicine (CHM) have excellent clinical efficacy for PCOS. however,there is currently a dearth of high-quality data demonstrating its efficacy.The purpose of this experiment is to assess the safety and efficacy, especially the long-term efficacy,of individualized life management、CHM, acupoint thread-embedding therapy for treating PCOS.
Methods and analysis: We present a multicentre, prospective, combined randomised clinical trial and observational cohort study design, with a target sample size of 316 patients with PCOS of the kidney deficiency and blood stasis type aged between 18-45years. Patients were divided into an observational cohort with a renal supplementation and blood-stasis-restoration cohort based on whether or not they were exposed to the tonifying-kidney, resolving-blood stasis-and-tongue method. Based on the examination results, the observation cohort received individualised life management and appropriate pharmacological interventions and was followed up for 6 months. The kidney tonifying and resolving stasis through the channels cohort was randomly divided into A) Kidney tonifying and resolving stasis traditional Chinese medicine group, B) Kidney tonifying and resolving stasis buried under ultrasound in the musculoskeletal bone group, and C) Kidney tonifying and resolving stasis traditional Chinese medicine combined with burying group by the method of randomised numerical table based on the above. The kidney tonifying and resolving stasis through the channels cohort treatment cycle was 3 months, and the follow-up period was 3 months. Main results: (1) the change of menstrual of PCOS patients before and after treatment ; (2) the efficacy of traditional Chinese medicine symptoms. Secondary results: Sex hormones, AMH, ultrasound;changes in scores such as polycystic cognition,PCOSQ-50 score,menstruation,hirsutism,Ffq168,IPAQ-SFHADS etc.All assessments were followed up with redcap questionnaires at baseline at weeks 4, 8, and 12 after the start of the intervention and at weeks 16, 20, and 24 after the end of the intervention.
Trial registration number: (2023) Lun Shen No.41; Pre-results.The trial was launched on July 2023 through https://www.chictr.org.cn/ Registrationnumber:ChiCTR2300073832.
Symptom Clusters and Symptom Network Analysis During Immunotherapy in Lung Cancer Patients
Authors: Yang Xuying , Bai Jincui , liu Ruili , Wang Xiaoping , Zhang Gongyu , Zhu Xuehua 
Published: February 2024

Abstract

Objective: This study aimed to analyze symptoms in lung cancer patients undergoing immunotherapy and to identify core symptom clusters through network analysis, thereby laying the groundwork for effective symptom management programs.
Methods: The study involved 240 lung cancer patients receiving immunotherapy. Participants were assessed using the memory symptom scale. Exploratory factor analysis extracted symptoms, and network analysis using JASP 0.17.3 explored centrality indices and density in these symptom networks.
Results: Five symptom clusters were identified: emotion-related, lung cancer-specific, perception, skin, and neurological symptom clusters, with a cumulative variance contribution rate of 55.819%. Network analysis revealed sadness as the most intense symptom (rs = 2.189), dizziness as the most central (rc = 1.388), and fatigue as the most significant bridging symptom (rB = 2.575).
Conclusion: This study identified five symptom clusters and networks during the immunotherapy in lung cancer patients. The centrality indices and network density from the network analysis can assist healthcare professionals in devising more precise symptom management strategies.
Comparison of locoregional recurrence risk among nipple-sparing mastectomy, skin-sparing mastectomy, and simple mastectomy in patients with ductal carcinoma in situ: A single-center study
Authors: Nashimoto Mika , Asano Yuko , Matsui Hiroki , Machida Youichi , Fukuma Eisuke 
Published: February 2024

Abstract

Background
In invasive breast cancer, there is no difference in mid- and long-term oncological safety results between nipple-sparing mastectomy (NSM), skin-sparing mastectomy (SSM) and simple mastectomy (SM). However, there are few reports on ductal carcinoma in situ (DCIS). This study aimed to compare the local recurrence and survival rates of the three techniques (NSM, SSM, and SM) in Japanese patients undergoing mastectomy for DCIS.
Methods
Patients undergoing NSM, SSM, and SM at our institution between 2006 and 2015 were identified, and their outcomes were analyzed.
Results
The mean follow-up period was 80.4 months (standard deviation [SD]: 37.1 months). NSM was performed in 152 cases, SSM in 49, and SM in 44. Five of 245 patients developed local recurrences. Four of these patients had invasive cancer. The primary endpoints of 5-year cumulative local recurrence were 2.4% (95% confidence interval [CI]: 0.0–5.0) for NSM, 2.2% (95% CI: 0.0–6.3) for SSM, and 0% (95% CI: 0.0–0.0) for SM. There were no significant differences in the 5-year local recurrence rate.
Conclusions
In conclusion, in our single-center, retrospective study, SSM and NSM showed oncological safety for DCIS that was comparable to that of conventional simple mastectomy.
Organogenesis in a broad spectrum of grape genotypes and Agrobacterium-mediated transformation of the Podarok Magaracha grapevine cultivar
Authors: Maletich Galina , Khvatkov Pavel , Pushin Alexander , Dolgov Sergey 
Published: February 2024

Abstract
We present data on the ability to organogenesis in 22 genotypes of grapevine and developed a direct organogenesis protocol for the cultivar Podarok Magaracha and the rootstock Kober 5BB. Protocol does not require replacement of culture media and growth regulators, the duration is 11 weeks. Cultivation of explants occurs on modified MS medium with the addition of 2.0 mg l-1 benzyladenine and indole-3-butyric acid (0.15 mg l-1 for the rootstock Kober 5BB or 0.05 mg l-1 for the cultivar Podarok Magaracha). The direct organogenesis protocol consists of three time periods: (1) culturing explants for 2 weeks in dark conditions for callogenesis, (2) followed by 4 weeks of cultivation in light conditions for regeneration, (3) 5 weeks of cultivation in dark conditions for shoot elongation. Based on this protocol, conditions for the Agrobacterium-mediated transformation of the Podarok Magaracha cultivar were developed with an efficiency of 2.0% transgenic plants per 100 explants. Two stably transformed lines with integration into the genome of the pBin35SGFP plasmid construction, confirmed by Southern blotting, were obtained.
Incidence and Characteristics of Aspiration Pneumonia in the Nagasaki Prefecture from 2005 to 2019
Authors: Tomonaga Iku , Koseki Hironobu , Imai Chieko , Shida Takayuki , Nishiyama Yuta , Yoshida Daisuke , Yokoo Seiichi , Osaki Makoto 
Published: February 2024

Abstract

Background
Aspiration pneumoniae remains a major health concern, particularly in the older population and has poor prognosis; however, the concept itself remains vague worldwide. This study aimed to determine the actual situation and characteristics of aspiration pneumonia from 2005 to 2019 in Nagasaki Prefecture, Japan.
Methods
Cases of aspiration pneumonia that occurred in the Nagasaki Prefecture between 2005 and 2019 were analyzed using emergency transportation records. The number of occurrences and that of incidence were analyzed according to age, sex, month, day of the week, and recognition time to clarify the actual situation of aspiration pneumonia.
Results
The total number of new aspiration pneumonia cases was 8,321, and the mean age of the patients was 83.0 years. Annual incidence per 100,000 population increased from 12.4 in 2005 to 65.1 in 2019, with the most prominent increase in the ≥ 80-year-old stratum. Males (55.1%) were more commonly affected than females (44.9%), and 82.2% of the cases involved patients aged ≥ 70 years. No significant correlations were observed between the incidence of aspiration pneumonia and season, month, or day of the week. Aspiration pneumonia occurred frequently in houses (39.8%) and facilities for elderly individuals (40.8%). At 7 days after admission, 80.9% of patients were still hospitalized and 6.5% had died.
Conclusions
The incidence of aspiration pneumonia with risks of severity and mortality is increasing among elderly individuals. Valid preventive measures are urgently needed based on the findings that the disease occurs in both household and elderly care facility settings, regardless of the season.
Early Thrombus Detection in the Extracorporeal Membrane Oxygenation Circuit by Noninvasive Real-time Ultrasonic Sensors
Authors: Rim Gongmin , Lim Zhongsoo , Lee Byungdoo , Kim Keunho , Yoo Ga young , Hyun Kwanyong , Cho Deog Gon 
Published: February 2024

Abstract

Background
Thrombus formation in extracorporeal membrane oxygenation (ECMO) remains a major concern as it can lead to fatal outcomes. To the best of our knowledge, there is no standard non-invasive method for quantitatively measuring thrombi. This study’s purpose was to verify thrombus detection in an ECMO circuit using novel, non-invasive ultrasonic sensors in real-time, utilizing the fact that the ultrasonic velocity in a thrombus is known to be higher than that in the blood.
Methods
Ultrasonic sensors with a customized chamber, an ultrasonic pulse-receiver, and a digital storage oscilloscope (DSO) were used to set up the measuring unit. The customized chamber was connected to an ECMO circuit primed with porcine blood. Thrombi formed from static porcine blood were placed in the circuit and ultrasonic signals were extracted from the oscilloscope at various ECMO flow rates of 1–4 L/min.
Results
The ultrasonic signal changes were successfully detected at each flow rate on the DSO. The ultrasonic pulse signal shifted leftward when a thrombus passed between the two ultrasonic sensors and was easily detected on the DSO screen.
Conclusion
This novel real-time non-invasive thrombus detection method may enable the early detection of floating thrombi in the ECMO system and early management of ECMO thrombi.
Hydrogen Bonding Template Enables Remote Meta-C–H Alkenylation of Nitroarenes
Authors: Maiti Debabrata , Dutta Bishal , Mahajan Mayank , Ghosh Animesh , Dajek Maciej , Kowalczyk Rafal , Mondal Bhaskar , Ge Haibo 
Published: February 2024

Abstract

Regioselective distal C-H functionalization of nitroarenes by overriding proximal C-H activation has remained an unsolved challenge. Herein, we present a palladium-catalyzed meta-C-H alkenylation of nitroarene substrate, achieved through leveraging the non-covalent hydrogen bonding interactions. Urea-based templates comprising an elongated biphenyl linker designed in such a way that it interacts with nitro group via strong hydrogen bonding interaction, while a cyano based directing group is attached along the template to coordinate with the palladium centre, thereby facilitating the activation of the remote meta-C-H bond of nitrobenzene. Computational mechanistic investigation and the analysis of non-covalent interaction deciphers the crucial role of H-bonding in regulating the regioselectivity.
Prevalence of Non-Consented Care During the Childbirth Process in Mexico by Geographical Regions: Comparing ENDIREH Survey Data from 2016 and 2021
Authors: Marian Marian , Barker Kathryn , Reed Elizabeth , McClain Amanda , Lundgren Rebecka , Hurst Samantha , Pérez Ramona L. 
Published: February 2024

Abstract
Introduction
Non-consented care, a form of obstetric violence that involves the lack of informed consent for procedures, is a common but little-understood phenomenon in the global public health arena. The aim of this secondary analysis was to measure the prevalence and assess change over time of non-consented care during childbirth in Mexico in 2016 and 2021, as well as to identify sociodemographic and pregnancy- and childbirth-related determinants of non-consented care, as the social factors associated with this type of violence are not well identified.
Methods
We measured the prevalence of non-consented care and three of its variations, forced sterilization or contraception, forced cesarean section, and forced consent on paperwork, during childbirth in Mexico for 2016 (N = 24,036) and 2021 (N = 19,322) using women’s self-report data from Mexico’s cross-sectional National Survey on the Dynamics of Household Relationships (ENDIREH). Weighted data were stratified by geographical regions. We performed adjusted logistic regression analyses to explore associations.
Results
The prevalence of non-consented care and pressure to get a contraceptive method increased from 2016 to 2021. A decrease in the prevalence was observed for forced contraception or sterilization, forcing to sign paperwork, and non-consented cesarean sections from 2016 to 2021 nationally and in most regions. Women between the ages of 26 and 35 years, married, cohabiting with partner, living in urban settings, who do not identify with an Indigenous belonging, and who received prenatal services or gave birth at the Mexican Institute of Social Security (IMSS) facilities experienced a higher prevalence of non-consented care during childbirth. Being 26 years of age and older, living in a rural setting, experiencing stillbirths in the last five years, having a vaginal delivery, receiving prenatal services at IMSS, or delivering at a private facility were significantly associated with higher odds of reporting non-consented care.
Conclusion
The prevalence of non-consented care continues to increase, regardless of the changes in the law that have occurred since 2016 related to obstetric violence. Our findings suggest the need to enforce current laws and strengthen health systems, paying special attention to the geographical regions and populations that have experienced higher reported cases of this structural problem.
Hepato-Curative Effect of Cholecalciferol (Vitamin D) on Fipronil-Induced Liver Damage via Up-regulation of AMPK-α, and PPAR-γ Signaling Pathways in Male Rats
Authors: Mohamed Nema Abdelhameed , Hussein Hussein Khamis , Attia Maha Mohamed , Hammad Mohamed Mouner , Abdou Heba Mohamed 
Published: February 2024

Abstract

FIP, is an abroad-spectrum phenylpyrazole insecticide, and/or its metabolites trigger the toxicity in liver via the mitochondrial respiratory chain inhibition. This work aimed to investigate the effect of vitamin D3 against FIP-induced liver toxicity in male rats. Vit. D3 attenuated liver markers, hepatic necrosis and inflammation, and dyslipidemia in FIP-intoxicated rats. Vit. D3 also reduced FIP-induced oxidative stress by increasing the activities of antioxidant enzymes, such as SOD, CAT, GPx, and GSH, and inhibiting lipid peroxidation products and nitric oxide levels in rat liver. Further investigations revealed that Vit. D3 counteracted FIP-induced increased levels of IL-6, TNF-α. Moreover, Vit. D3 up-regulated the AMPK-α, and PPAR-γ mRNA gene expression. In addition, Vit D3 improved the histopathological changes caused by FIP. In conclusion, Vit. D3 prevented liver damage in FIP-treated rats via augmentation of antioxidant defense mechanisms and inhibition of inflammatory cytokines/mediators and up-regulation of AMPK-α, and PPAR-γ.
Irradiated Microparticles Suppress Prostate Cancer by Tumor Microenvironment Reprogramming and Ferroptosis
Authors: Deng Zihan , Li Binghui , Yang Muyang , Lu Lisen , Shi Xiujuan , Lovell Jonathan , Zeng Xiantao , Hu Weidong , Jin Honglin 
Published: February 2024

Abstract

Immunogenic cell death (ICD) plays a crucial role in triggering the antitumor immune response in the tumor microenvironment (TME) through the release of damage-associated molecular patterns (DAMPs). Recently, considerable attention has been dedicated to ferroptosis, a type of ICD that is induced by intracellular iron and has been demonstrated to change the immune desert status of the TME. However, there remains significant room for improvement among strategies for inducing high levels of ICD through ferroptosis to fight cancers that are characterized by an immune desert, such as prostate cancer. Radiated tumor cell-derived microparticles (RMPs) are radiotherapy mimetics that have been shown to activate the cGAS-STING pathway, induce tumor cell ferroptosis, and inhibit M2 macrophage polarization. RMPs can also act as carriers of agents with remarkable biocompatibility. In the present study, we designed a therapeutic system wherein the ferroptosis inducer RSL-3 was loaded into RMPs to treat prostate cancer, which is considered a cold tumor, using in vitro and in vivo models involving RM-1 prostate carcinoma cells. Apoptosis inducer CT20 peptide (CT20p) was also added into the RMPs to aggravate ICD. In vitro experiments demonstrated that RSL-3- and CT20p-loaded RMPs (RC@RMPs) led to ferroptosis and apoptosis of RM-1 cells, and CT20p had a synergistic effect on ferroptosis by promoting ROS production and mitochondrial instability. RC@RMPs elevated the dendritic cell (DC) expression of MHCⅡ, CD80, and CD86 and facilitated M1 macrophage polarization. In a syngeneic mouse model of prostate cancer induced by RM-1 cells, RC@RMPs significantly inhibited tumor growth and prolonged survival time via DC activation, macrophage reprogramming, enhancement of CD8+ T cell presence, and proinflammatory cytokine production, without diffusing outside the tumor tissue. Moreover, combination treatment with anti-PD-1 showed improved effectiveness to inhibit RM-1 progression. This method provides a novel strategy for the synergistic enhancement of ICD for prostate cancer immunotherapies.
Chatter Detection in Simulated Machining Data: A Simple Refined Approach to Vibration Data
Authors: Alberts Matthew , Coble Jamie , Jared Bradley , Karandikar Jaydeep , Khojandi Anahita , Schmitz Tony , John Sam St. 
Published: February 2024

Abstract

Vibration monitoring is a critical aspect of assessing the health and performance of machinery and industrial processes. This study explores the application of machine learning techniques, specifically the Random Forest (RF) classification model, to predict and classify chatter—a detrimental self-excited vibration phenomenon—during machining operations. While sophisticated methods have been employed to address chatter, this research investigates the efficacy of a novel approach to a RF model. The study leverages simulated vibration data, bypassing resource-intensive real-world data collection, to develop a versatile chatter detection model applicable across diverse machining configurations.The feature extraction process combines time-series features and Fast Fourier Transform (FFT) data features, streamlining the model while addressing challenges posed by feature selection. By focusing on the RF model's simplicity and efficiency, this research advances chatter detection techniques, offering a practical tool with improved generalizability, computational efficiency, and ease of interpretation. The study demonstrates that innovation can reside in simplicity, opening avenues for wider applicability and accelerated progress in the machining industry.
Pure rotation in the temporomandibular joint during jaw opening? A digital motion analysis.
Authors: Jász Bálint , Balogh Tamás , Ambrus Szilvia , Schmidt Péter , Bányai Gréta , Körmendi Szandra , Jász Máté 
Published: February 2024

Abstract
Objective: The mandibular joint is a complex joint despite its relatively small size. Two separate movements of rotation and translation occur in two articular spaces during mouth opening. Over the years, the approach has changed considerably, but it is still subject to controversy as to which movement is involved in the initial stage of mouth opening, and even whether translation is performed. In the present study, the extent of rotation and translation was investigated in the first 5 mm of mouth opening.
Materials and methods: The study was carried out on 46 volunteers. Anamnesis was taken and patients were examined. A digital motion analysis was made, with ultrasonic transducers (KaVo Arcus Digma 2). With this device, various mandibular movements can be analysed with an extremely high accuracy of 50 micrometres. Each participant performed 3 open-close movements in succession, starting from maximum intercuspal position.
Results: Data were statistically processed using cubic spline interpolation. Linear regression was then used. The resulting line is significantly (p<0.0001) different from the horizontal that represents only rotational movement.
Conclusion: The results show that during mouth opening from maximum intercuspal position, translation is all the time present in addition to rotation.
Evidence of electron interaction with an unidentified bosonic mode in superconductor CsCa2Fe4As4F2
Authors: Jiang Juan , Li Peng , Liao Sen , Wang Zhicheng , Li Huaxun , Zhang Jiakang , Chen Ziyuan , Jiang Zhicheng , Liu Zhengtai , Yang Lexian , Huai Linwei , He Junfeng , Cui Shengtao , Sun Zhe , Yan Ya-Jun , Cao Guanghan , Shen Dawei , Feng Donglai 
Published: February 2024

Abstract

Using angle-resolved photoemission spectroscopy, we report the evidence of the observation of a kink structure in the band dispersion of Fe-based superconductor CsCa2Fe4As4F2. The kink shows an orbital selective and momentum dependent behavior, which is located at 15 meV below Fermi level along the Γ - M direction at the band with dxz orbital character and vanishes when approaching the Γ - X direction, correlated with a slight decrease of the superconducting gap. Most importantly, this kink structure disappears when the superconducting gap closes, indicating that the corresponding bosonic mode (~ 9 ± 1 meV) is closely related to superconductivity. However, the origin of this mode remains unidentified, since it cannot be related to phonons or the spin resonance mode (~ 15 meV) observed by inelastic neutron scattering. The behavior of this mode is rather unique and challenges our present understanding of the superconducting paring mechanism of the bilayer FeAs-based superconductors.