bluuebunny/crossref_metadata_2025_split huggingface dataset:
Research on the coupling measurement of medical higher education and health resource allocation in the context of healthy China
Authors: Zhu Yan , Song Zhilong , Li Siyuan , Wu Xiangwei , Chen jieting 
Published: October 2023

Abstract

Background: To analyze the coupling coordination level of medical education and health resource allocation in China to promote efficient resource allocation and provide a scientific basis for high-quality medical education development.
Methods: Based on panel data from 2011 to 2021, the coupling coordination degree model was used to measure the coupling coordination index of medical education and health resources in China by analyzing the spatial autocorrelation model two-system development and distribution characteristics of the coupling coordination degree, using kernel density estimation method analysis of the two-coordinate system coupling dynamic evolution trend, and usingthe QR quantile regression model to explore the key factors influencing the coupling coordination degree of the two systems.
Results: During the observation period, the two-system coupling coordination degree increased from 0.393 to 0.465, with a growth rate of 18.3%. With space correlation among the provinces and 25.81% of the provinces in transition, in the process of the dynamic distribution system of the two coupling coordination degrees of the polarization curve gradually increased. Per capita GDP, population scale, research and development innovation are two driving systems coupling strong coordinated development.
Conclusion: Regarding the allocation of health resources and medical education in Turkey, the coupling coordination degree increases steadily, but the spatial agglomeration identities are polarized, and social, economic and demographic factors have different degrees of influence on coupling the two systems. Coordinated development mechanisms to innovate on the basis of the two systems promote medical higher education and the allocation of health resources in the two-way flow of talent, technology and other factors, in turn promoting the system coupling of coordinated development.
Geriatric nutritional risk index and newly developed scoring system as prognosis prediction for unresectable hepatocellular carcinoma patients treated with lenvatinib
Authors: Ohama Hideko , Hiraoka Atsushi , Tada Toshifumi , Hirooka Masashi , Kariyama Kazuya , Tani Joji , Atsukawa Masanori , Takaguchi Koichi , Itobayashi Ei , Fukunishi Shinya , Tsuji Kunihiko , Ishikawa Toru , Tajiri Kazuto , Ochi Hironori , Yasuda Satoshi , Toyoda Hidenori , Ogawa Chikara , Nishimura Takashi , Hatanaka Takeshi , Kakizaki Satoru , Shimada Noritomo , Kawata Kazuhito , Naganuma Atsushi , Kosaka Hisashi , Matono Tomomitsu , Kuroda Hidekatsu , Yata Yutaka , Tanaka Hironori , Nishikawa Hiroki , Shibata Hiroshi , Tada Fujimasa , Nouso Kazuhiro , Morishita Asahiro , Tsutsui Akemi , Nagano Takuya , Itokawa Norio , Okubo Tomomi , Arai Taeang , Imai Michitaka , Koizumi Yohei , Nakamura Shinichiro , Iijima Hiroko , Kaibori Masaki , Hiasa Yoichi , Kumada Takashi 
Published: October 2023

Abstract

Background/Aim:
In the current era of immune therapy, lenvatinib (LEN) continues to be vital for treating unresectable hepatocellular carcinoma (uHCC) patients. This study investigates the importance of nutritional status in the prognosis of uHCC patients receiving LEN treatment and evaluates a new prognostic scoring system that combines the geriatric nutritional risk index (GNRI) and systemic inflammatory response.
Methods:
From April 2018 to December 2022, 484 uHCC patients treated with LEN (384 males, median age 73). Prognostic value was compared between the GNRI and C-reactive protein(CRP) scoring(GNRI-C score), GNRI, and neo-Glasgow prognostic score(neo-GPS) using modified albumin-bilirubin grade and CRP. Evaluation was based on the Akaike information criterion(AIC) and concordance index(c-index).
Results:
Median progression-free survival(mPFS) was 9.3/6.8/4.6 months for GNRI no-risk/low-risk/moderate-to-major risk(p<0.01, AIC 4742.4/c-index 0.585). Median overall survival(mOS) was 27.8/15.2/9.5 months(p<0.01, AIC 3433.34/c-index 0.639). For GNRI-C score, mPFS was 10.8/7.1/5.6/4.0 months(score 0/1/2/3) (p<0.01, AIC 4732.82/c-index 0.6), while neo-GPS showed mPFS of 8.5/5.1/5.2 months(p<0.01, AIC 4745.89/c-index 0.562). For mOS, GNRI-C score demonstrated 28.6/20.0/10.1/8.4 months(score 0/1/2/3) (p<0.01, AIC 3420.27/c-index 0.652), while neo-GPS indicated 21.0/12.4/ /4.5 months (p<0.01, AIC 3468.84/c-index 0.564).
Discussion/Conclusion:
The newly devised GNRI-C score, incorporating nutritional and inflammatory markers, could offer improved prognostic predictions for uHCC patients treated with LEN.
Comparative study of modified Koyanagi and staged Duckett for proximal hypospadias
Authors: Ji Fengming , Tang Haoyu , Chen Junlin , Yao Guiping , ZhangHuang Chenghao , Yan Bing 
Published: October 2023

Abstract
Aim
To compare and analyze the clinical efficacy of modified Koyanagi and staged Duckett for proximal hypospadias.
Method
The clinical and prognostic data of children were treated and underwent surgery (modified Koyanagi or stage Duckett) in the Department of Urology, Kunming Children's Hospital from January 2020 to January 2023 were retrospectively analyzed. According to different surgical methods, the subjects were divided into the modified Koyanagi group and the staged Duckett group. Patients in both groups were followed up for more than 6 months after surgery. The success rate and complications of postoperative surgery in both groups were analyzed.
Result
A total of 63 patients were included in this study, 34 in the modified Koyanagi group and 29 in the staged Duckett group. A total of 14 patients in the modified Koyanagi group experienced postoperative complications, the success rate of the surgery was 58.82%, and 5 among them experienced more than two kinds of complications. A total of 5 children in the staging Duckett group experienced postoperative complications, and the success rate of the operation was 82.75%. There were significant differences in the incidence of overall complications and fistula between the two surgical methods (P = 0.028).
A Quantum-Levy and variable neighborhood-enhanced metaheuristic for supply hub-based green pickup heterogeneous vehicle routing problem
Authors: Zhou Binghai , Wang Honghui 
Published: October 2023

Abstract

Due to the growing interest in green logistics and the challenge of just-in-time part logistics, as well as considering the current popularity of supply hub, this paper focuses on a supply hub-based green pickup heterogeneous vehicle routing problem with capacity constraints (CGPHVRP) in the automobile industry. An integer programming model is therefore established, aiming to minimize the total energy consumption for executing all pickup tasks and the total penalty costs imposed on early and late deliveries. The epsilon constraint method is utilized to verify the validity of the proposed model. To solve this problem which is inherently NP-hard, a Quantum-Levy and variable neighborhood-enhanced multi-objective honey badger algorithm (QLVNMHBA) is proposed. Taking advantages of both Quantum behavior and Levy flight, the Quantum-Levy strategy is presented to enhance the exploration. Simultaneously, the adaptive variable neighborhood search including three innovative neighborhood operators is designed to enhance the exploitation and fasten the convergence speed. Furthermore, the convex lens imaging opposition-based learning is applied to initialize the population. Finally, computational experiments reveal that the QLVNMHBA outperforms the other four state-of-the-art algorithms in both solution quality and convergence speed, and the use of heterogeneous fleet could achieve significant reductions in energy consumption over a homogeneous one. Moreover, a specific case is applied to demonstrate the practicality of the proposed model and algorithm.
Nutritional composition of cricket, Brachytrupes membranaceus (Drury, 1770) and selected animal source foods in Cross River State, Nigeria
Authors: Okweche Simon Idoko , Ugwu Queendaline. O , Oko Pius Agaji 
Published: October 2023

Abstract

Brachytrupes membranaceus (Drury) is one of the edible crickets consumed in Nigeria as a source of nutrient proteins by majorly children, specifically during the wet seasons of the year. This study was conducted to compare the nutrient content of cricket and other animal protein sources. Majority of Nigerians are in dire need of alternative food sources with high protein contents other than the most commonly used; beef, goat meat, chicken, and fish which cannot be afforded by the majority of low-income earners. There is a lack of information on the nutrient composition of edible insects with particular reference to crickets in Nigeria. Nutrient composition (moisture content, ash content, fat, crude fibre, crude protein, and carbohydrate) of cricket, fish, egg, goat meat, and beef was therefore evaluated in the Department of Physical and Applied Chemistry, University of Calabar, Nigeria. Moisture content was determined by percentage moisture using the oven drying method as described by the Association of Official Analytical Chemists. Fat content was determined using the procedure of AOAC using n-hexane as solvent. Crude fibre was determined by sequential hot digestion of defatted sample with dilute acid and alkaline solutions. Crude protein content was evaluated using the macro Kjeldahl method. Carbohydrate was determined by differential calculation which involves carbohydrates, moisture content, protein and crude ash. The result showed that cricket has low amount of ash, high amount of crude fibre, low carbohydrate compared with other sources. However, cricket and fish recorded higher amount of protein compared with other nutrient sources. Although fish was the most expensive source of food source that could easily be afforded by the upper class. In conclusion, edible insects which have little or no value in our daily diet are strongly recommended for consumption due to their protein content and cost, which is significantly lower than other protein sources.
Heatwave predicts a shady future for insects: impacts of an extreme weather event on a chalk grassland in Bedfordshire, UK.
Authors: Hayes Matthew P. , Ashe-Jepson Esme , Hitchcock Gwen E. , Clark Ryan , Hellon Josh , Knock Richard I. , Bladon Andrew J. , Turner Edgar C. 
Published: October 2023

Abstract
Climate change is set to become one of the leading causes of biodiversity loss worldwide, with extreme weather events projected to increase in frequency. Ectothermic animals such as insects are at particular risk, especially when they are isolated and unable to move through the landscape to track suitable climate. To protect such taxa, it is important to understand how they are impacted by extreme weather events and whether management could provide effective microclimate refuges. However, potential management interventions remain untested for many species. Here, we show that extreme high temperatures experienced in the UK on 19th July 2022 resulted in a community of butterflies becoming inactive, but that shaded areas, including artificial slopes created as part of conservation management for climate change, provided a refuge during this period. Our results indicate that future high temperatures could force butterflies to shelter in the shade, potentially being unable to fly, feed or mate during these periods, with potential long-term impacts.
Implications for Insect Conservation
Producing artificial slopes and integrating patches of scrub within grassland could create an array of microclimates that allow butterflies and other invertebrates to thermoregulate, providing a refuge during extreme weather events. Our findings highlight the dramatic effect of extreme temperatures on insect communities, as well as simple management solutions that could be implemented widely and relatively easily by conservation managers, to counter some of the negative impacts of rising temperatures and extreme weather events.
Primary Pancreatic GIST- A single centre case series and systematic review of literature
Authors: Gupta Vipul , Chopde Amit , Chaudhari Vikram , Bal Munita , Shrikhande Shailesh V , Bhandare Manish 
Published: October 2023

Abstract
There is evolving literature on similarities and differences between GIST and EGIST. Despite their behavioural similarities, results cannot be generalised to larger population due to lack of evidence. Pancreatic GIST is a rare entity. There are many documented case reports, however long term data is unavailable. Our case series is by far the largest single centre series with long follow up data but with limited number of cases. Survival values cannot be generalised due to limited data. Large case series are required to further understand the disease biology and long term outcomes of pancreatic GIST.
The impact of inflammatory cells on lung function in asthmatics in a cross sectional retrospect study
Authors: Li Yujuan , Jin Faguang , Zhao Qi , Chen Yanwei , Liu Gang 
Published: October 2023

Abstract

Background: Limited data exists on the impact of inflammatory cells and clinical characteristics on lung function in individuals with asthma.
Objective: The objective is to examine the correlation between increased inflammatory cells, asthma symptoms, and lung function in patients with asthma in a clinical setting.
Methods: A retrospective cohort study was conducted on 234 individuals suspected of having asthma in Xian, China between January 2008 and December 2021. Of those, 143 patients with complete clinical feature and lung function data were enrolled to examine the relationship between increased inflammatory cells, asthma symptoms, and lung function. Basic characteristics, blood eosinophil count, blood neutrophil count, blood platelet count, blood C-reactive protein (CRP), and comprehensive lung function analysis were evaluated at each inpatient for the 143 adult asthmatics. The association between inflammatory cells and clinical parameters with pulmonary function was compared.
Results: The results of the study showed that individuals in the alcohol intake group had elevated blood eosinophil count compared to those in the non-alcohol intake group (P=0.024). Long-acting inhaled beta 2 agonists and antibiotic therapy were associated with lower blood eosinophil count (P=0.021 and P=0.049, respectively) compared to other therapy.There was a independent association between blood eosinophil counts and FEV1 pre- and post-therapy in asthma but there was a markedly correlation between blood eosinophil counts and FEV1/FVC pre-and post-therapy in Asthma(P=0.007). Blood neutrophil counts were inversely correlated with FEV1/FVC after treatment (P=0.032). Night onset in asthma was positively correlated with blood neutrophil counts, while fever was negatively correlated with blood CRP (P=0.028). Platelet counts >300×109/L after treatment were significantly associated with a decline in FEV (<0.001) in patients with asthma. Elevated blood eosinophil count was independently associated with clinical features in asthma.
Conclusions: Based on the study's findings, there is a significant decline in FEV1/FVC among individuals with elevated blood eosinophil count, both pre- and post-bronchodilator while there was a independent relationship between blood eosinophil counts and FEV1 pre-and post-therapy in asthma. This suggests that increased levels of eosinophils may independently associated contribute to reduced lung function in asthma patients.
A Two-Fault Detection and Elimination Approach to the Receiver Autonomous Integrity Monitoring
Authors: WU Qi'an 
Published: October 2023

Abstract

The Receiver Autonomous Integrity Monitoring (RAIM) technique is very important for the GNSS receiver to detect faulty measurement sources before they mislead the positioning solution. Based on the parity RAIM method, a simple algorithm to detect and eliminate one fault is provided. However, there is no such a simple algorithm to detect and eliminate two faults. A general approach is traversing all possible fault cases and calculate the sum of the squares of the residual errors (SSE) of each case by solving the observation equation. However, solving the observation equation takes a lot of computation. This paper proposes a detection and elimination algorithm that can deal with no more than 2 faults, based on the least-squares-residual method. The new algorithm avoids solving the observation equation for each possible fault cases, and has very low computational complexity. Simulations are done to evaluate the performance of the algorithm, and the effect of the satellite geometry conditions on the algorithm is also discussed.
GDF15 Improves Lipopolysaccharide-Induced Myocardial Dysfunction By Inhibiting Cardiomyocyte Ferroptosis Via The SOCS1/GPX4 Signaling Pathway Regulation
Authors: Li Xiayun , Zhang Liyun , Zhu Hanzhao , Zhang Bin , Yang Jiachang , Wang Xiaoya , Sun Jingwei , Zhou Yang , Zhai Mengen , Yi Wei , Jiang Liqing , Duan Weixun 
Published: October 2023

Abstract
Septic cardiomyopathy is a cardiac disease with an extremely high mortality rate. Cardiomyocyte ferroptosis is an important pathological process in septic cardiomyopathy, which is attributed to reactive oxygen species (ROS) production and lipid peroxidation. Growth differentiation factor 15 (GDF15) has significant antioxidant effects and exerts therapeutic effects in cardiovascular diseases. However, the function and mechanism of GDF15 in septic cardiomyopathy remain unclear. A sepsis model was established by intraperitoneal injection of lipopolysaccharide (LPS, 10 mg/kg) to C57BL/6 male mice. Subsequently, cardiac function was assessed, indicators of myocardial ROS, lipid peroxidation and ferroptosis were also detected. We found that myocardial systolic function was severely impaired in parallel with ROS accumulation, enhanced lipid peroxidation, and increased cardiomyocyte ferroptosis in septic mice, after injecting GDF15, these adverse changes were markedly reversed. Whereas GDF15 antibody (Ab-GDF15) treatment, which can neutralize GDF15 in the circulation, made adverse cardiac changes worse. In terms of the mechanism, RNA sequencing showed that suppressor of cytokine signaling 1 (SOCS1) is a key regulatory molecule downstream of GDF15. Additionally, GDF15 significantly enhanced the expression of ferroptosis markers glutathione peroxidase 4 (GPX4) by inhibiting SOCS1 expression. Overexpression of SOCS1 reversed the beneficial effects of GDF15 on cardiac function, and promoted cardiomyocyte ferroptosis. Above findings demonstrate that GDF15 improves cardiac function and reduces cardiomyocyte ferroptosis by regulating the SOCS1/GPX4 signaling pathway in septic cardiomyopathy. This experiment provides a basis for further evaluation of GDF15 as a therapeutic agent for septic cardiomyopathy.
Extremely Efficient Adsorption of Rhodamine B dye from Aqueous Solutions onto Modified Olive Stone Activated Carbon: Modelling and Optimization Studies
Authors: Can Mert , OZCAN Duygu OVA , OVEZ Bikem 
Published: October 2023

Abstract
In this study, the adsorption performances of ZnCl2, KOH and H3PO4 impregnated activated carbons derived from olive stones in the removal of Rhodamine B dye from aqueous solution were investigated. The equilibrium time was determined to be 6 hours, and the highest adsorption capacity was achieved by ZnCl2 impregnation (190.67 mg g-1) followed by KOH (118.26 mg g-1), H3PO4 (49.81 mg g-1), and crude olive stones (21.57 mg g-1) compared to the commercial powdered activated carbon (254.30 mg g-1). While different pH values (2-10) did not exhibit much effect, pH 4 was the most efficient one. The sorption capacity reached equilibrium at 200 mg L-1 of initial dye concentration. 0.01 gram of ZOSAC had 39% removal performance, whereas 0.05 gram was found to be sufficient for 100% removal. The presence of background ions enhanced the adsorption of Rhodamine B. Pseudo-second order model (R2=0.99) was most suitable for the experimental data among kinetic models. Redlich-Peterson (R2>0.98) model was found to be most suitable equilibrium model for all ACs. The temperature increase from 30 to 50℃ had an increasing effect on the adsorption capacity. It was also revealed that the adsorption was endothermic (∆H°=14.91 kJ mol-1) and thermodynamically favorable (∆G°<0) for ZOSAC. At the end of the fifth adsorption/desorption cycle, the removal efficiency was 94% and optimum adsorption conditions were determined as 45 ℃ and 252 mg L-1. As a result, ZOSAC was found to be the most efficient and reusable impregnated olive stone derived activated carbon in the Rhodamine B removal.
Harnessing exogenous membrane vesicles for studying Fusarium circinatum and its biofilm communities
Authors: Motaung Thabiso E , Ratsoma Francinah M , Kunene Sithembile , Santana Quentin C , Steenkamp Emma T , Wingfield Brenda D 
Published: October 2023

Abstract

Extracellular vesicles (EVs) are tiny messengers that convey bioactive molecules from donor to recipient cells, leading to changes in their physiology and function. We investigated the role of EVs in shaping growth and the biofilm biology of the tree pathogen Fusarium circinatum and its interaction with the susceptible host, Pinus patula. Vesicles were collected from fungal planktonic and biofilm cultures and from pine seedling needles and roots. The physical properties of these vesicles were analysed using nanoparticle tracking analysis and transmission electron microscopy, which revealed a diverse range of sizes and shapes, respectively. Furthermore, uptake of vesicles by conidia demonstrated that F. circinatum EVs significantly but variably affected spore viability during the early phase (2-4 h) although they enhanced biomass and extracellular matrix (ECM) production in biofilms. In contrast, P. patulaEVs greatly inhibited hyphal formation and biofilm biomass, but failed to inhibit ECM biosynthesis in the fungal biofilm. Our results therefore suggest that conidial germination is essential for late fungal development including hyphal and biofilm formation while matrix production may be a counter measure against harsh environmental conditions including the effects of plant-derived EVs. Therefore, plant-microbe interactions viewed within the context of biofilm formation can improve understanding into the dynamic and complex behaviours of fungal pathogens and their interactions with plant hosts.