bluuebunny/crossref_metadata_2025_split huggingface dataset:
Comparison of ovarian induction outcome in Mongolian women classified by POSEIDON criteria
Authors: Dagvadorj Bolormaa , Enkhmaa Davaasambuu , Erdenebileg Nasantogtokh , Warburton David , Jamsranjav Enkhtsetseg , Altantuya Shirchinjav 
Published: January 2024

Abstract

Background
Infertility has become a global issue, affecting 12.6–17.5% of women of reproductive age or 48.5 million couples. Infertility depends inversely on age, though, it is observed that young women are also now facing diminished ovarian reserve. Poor response to ovarian stimulation relates to the decreased ovarian reserve, and their remaining primordial, primary and secondary follicles have less sensitivity to Follicular stimulation hormone (FSH). The Patient-Oriented Strategy Encompassing Individualized Oocyte Number (POSEIDON) criteria have been proposed as a means to predict and plan the treatment of patients with poor ovarian responsiveness.
Methods
Here in, we report on implementation of the POSEIDON criteria for assessing ovarian response and compared assisted reproductive technology (ART) outcomes for women presenting with infertility at our clinic in Ulaanbaatar, Mongolia.
Results
The study included 158 women aged 23–45 years who were diagnosed with infertility. The participants’ mean age was 33.6 ± 5.3 years, their Body mass index (BMI) was 25.06 ± 3.86, and 88.0% (n = 139) of the patients were married. We evaluated the impact of the POSEIDON criteria on successful pregnancy by using logistic regression analysis. The probability of successful pregnancy is 2.2 times higher for POSEIDON group 1 and 2.3 times higher for group 2 compared to group 4.
Conclusions
The outcome of successful pregnancy can potentially be improved when assessing infertile Mongolian women and planning treatment by implementation of the use of the POSEIDON criteria.
Research on Water Quality Prediction of Mine Surroundings Based on Improved Machine Learning Algorithm
Authors: Liu Xihui , Gao Jingwei 
Published: January 2024

Abstract
Acid Mine Drainage (AMD) poses a significant environmental challenge, frequently occurring at mining, smelting, and closed mine locations. This phenomenon arises when sulfide ores come into contact with oxygen and water, forming sulfuric acid. This acid subsequently dissolves in mine water, increasing its acidity. Sulfate (SO4) serves as a crucial indicator of acid mine water quality. Precise prediction of SO4 concentrations post-treatment is essential for achieving compliant and stable wastewater discharge, thereby mitigating environmental risks. In this paper, we introduce IPSO-GRU, a novel artificial intelligence algorithm designed to predict water quality accurately. Our IPSO-GRU model employs particle swarm optimization to enhance support vector regression for SO4 prediction. The performance indices of the model show a Root Mean Square Error (RMSE) of 0.104, a Mean Absolute Error (MAE) of 0.061, and a Coefficient of Determination (R²) of 0.79. Comparative evaluations with IPSO-RNN and IPSO-LSTM models reveal that IPSO-GRU outperforms these alternatives across RMSE, MAE, and R² metrics, confirming its efficacy as the most suitable model for predicting SO4 concentrations in mine wastewater.
How well do endemic wetland plant species perform in water purification?
Authors: Frenzel Philip , Brunings Olivia , Esler Karen J , Maitre David C Le , Rebelo Alanna J. 
Published: January 2024

Abstract

Rising anthropogenic-induced nutrient enrichment of surface waters is of great concern globally as it jeopardizes the ecological integrity and functioning of freshwater ecosystems. Floating wetlands have been successfully used to treat nutrient enriched wastewater in developing nations, and provide additional co-benefits. We aimed to quantify the nutrient removal efficiency of high-potential, locally endemic wetland species on floating wetlands in different conditions and to understand whether the nutrient uptake process was characterised by key plant functional traits. Two experiments were run under Mediterranean-climate conditions of the Western Cape of South Africa: (1) a closed, oligotrophic mesocosm experiment representing local conditions and (2) a real-life (in-situ) eutrophic application. The mesocosm experiment conducted under oligotrophic local conditions yielded low nitrate, phosphate and ammonium removal rates (34.8-35.2 mgNO3-Nm-2.d-1, 10.4-10.7 mgPO4-Pm-2.d-1 and 3.6-3.8 mgNH4-Nm-2.d-1) in comparison to other floating wetland studies globally, yet high removal efficiencies (>90%). However the eutrophic in-situ experiment demonstrated the potential for these same locally endemic plants to remove up to 312 g.m-2 of nitrogen and 47 g.m-2 of phosphorus per year– which is relatively high compared to similar global research. Cyperus textilis had the highest daily nutrient uptake and content followed by Prionium serratum and Juncus lomatophyllus, while J. lomatophyllus had the greatest nutrient uptake efficiency. Two of the three species (C. textilis and P. serratum) stored significantly more total nutrients in their shoot tissue compared to their root tissue, suggesting that the permanent removal of nutrients from the system is possible through shoot harvesting. Floating wetlands planted with endemic plant species have the potential to remove nutrients effectively and sustainably from eutrophic water and can thus be implemented as low-cost nature-based solutions to mitigate pollution of lentic systems.
Spatial Distribution of Antioxidant Activity in Baguette and Its Modulation of Proinflammatory Cytokines in RAW264.7 Macrophages
Authors: Gu Huaiyu , Zou Jianqiao , Yu Zhaoshuo , Ke Lijing , He Fangzhou , Wall Patrick 
Published: January 2024

Abstract

Baguette, a globally acclaimed bakery staple, undergoes a complex Maillard reaction during the baking process, imparting a dual composition of crispy crust and soft crumb. Maillard reaction contributes to the unique flavor and texture of baguettes. However, its specific impact on the nutritional and health attributes, particularly in terms of cellular and biological functions, are yet to be clearly elucidated. This study investigates the chemical profiles of Maillard reaction products (MRPs) in baguette crust and crumb, and spatial distribution variations in the antioxidant activity. The impacts of baguette crust and crumb on cellular reactive oxygen species, mitochondrial activity, and inflammatory factors in RAW264.7 macrophages are also determined, aiming to elucidate the influence of the Maillard reaction on baguette nutritional efficacy.
From the inside out, both the browning intensity and advanced glycation end products (AGEs) gradually increased, accompanied by a significant elevation in the antioxidant capacity of the crust (tested using ORAC/ABTS/FRAP). This suggests that the Maillard reaction enhances antioxidative properties. Additionally, both the crust and crumb exhibited a strong cytocompatibility for immune cells with capable of reversing cellular oxidative stress, regulating intracellular free radical levels. The crust mitigated the peroxyl radical induced cell membrane hyperpolarization by 91% and the suppression on the oxygen respiration in mitochondria by up to 100%, showing higher activities than the crumb. Conversely, the crumb more effectively inhibited the lipopolysaccharide (LPS)-induced proinflammatory cytokines expression of interleukin-1β (IL-1β) and interleukin-6 (IL-6) in macrophages. It could provide the fundamental data and cell-based approach for investigating the biological impacts of bread on mucosal immune responses, contributing to the refinement and supplementation of nutritional recommendations.
Spatio-Temporal Dynamics of Groundwater Storage in Pakistan from Gravimetric Observations
Authors: Hannan Muhammad , Dars Ghulam Hussain , Ukasha Muhammad , Ansari Kamran 
Published: January 2024

Abstract
Groundwater is the predominant water source in Pakistan, meeting the needs of industry, agriculture, and households. This study investigates groundwater storage variations in Pakistan and mainly focus at the provincial levels from 2003 to 2022 using Gravity Recovery and Climate Experiment (GRACE) observed terrestrial water storage anomalies (TWSA) and water storage components from Global Land Data Assimilation System (GLDAS). The analysis reveals significant fluctuations in groundwater storage levels, influenced by various factors, including seasonal changes in precipitation and agricultural activities. The study highlights substantial decline in groundwater storage over the last decade. The spatial analysis uncovers uneven patterns of groundwater storage variations across the country. Punjab and Sindh provinces are notable for their distinct and significant changes, including declines and slightly increases, respectively, compared to other regions. These findings underscore the importance of sustainable groundwater management practices, particularly in provinces and regions with heightened extraction rates and susceptibility to drought and flood events. Floods significantly increase groundwater recharge, while drought-affected areas show noticeable decreases in groundwater storage. This research contributes to a better understanding of Pakistan's groundwater dynamics. It emphasizes the need for effective policies to ensure long-term water resource sustainability in changing climate conditions and human activities.
Research on developing a predictive model for radiation pneumonitis risk based on radiomics and multiparameters
Authors: Zhu Jun , Song Xinmiao , Zhang Meng , Li Fuqiang , Chen Hong , Li Yi 
Published: January 2024

Abstract

Objective A Nomogram model was constructed by combined pre-treatment CT radiomics, clinical characteristics, and lung dosimetry data of patients with non-small cell lung cancer,and to explore its predictive value of radiation pneumonitis.
Methods A retrospective analysis was conducted on 104 non-surgical NSCLC patients who underwent chest intensity modulated radiation therapy(IMRT) at our center from January 2013 to December 2017. Intratumoral and peritumoral radiomics models were established using pre-radiotherapy CT images, and logistic regression was used to screen for the best clinical and dosimetric parameters. A combined Nomogram model was established by the above parameters, and receiver operating characteristic curve (ROC) analysis and area under the curve (AUC) was performed to estimate its predictive efficacy of radiation pneumonia.
Results Among 104 patients, 59 cases developed radiopneumonia and 45 cases did not suffer from radiopneumonia within 6 months after radiotherapy, which were divided into 73 cases in the training set and 31 cases in the validation set. The AUC values of the intratumoral radiomics group model in the training and validation sets were 0.871 (95%CI 0.771~0.938) and 0.719 (95%CI 0.400~0.952), respectively, and the predictive efficacy was better than that of the peritumoral radiomics group model [0.798 (95%CI 0.629~0.921) and 0.714 (95%CI 0.500 ~0.857)]. Multifactorial regression analysis showed that patients' age, smoking, and pre-radiotherapy lymphocyte ratio were associated with radiation pneumonitis (P<0.05); physical dosimetric parameters of MLD and lung V20Gy were associated with radiation pneumonitis (P<0.05).The Nomogram model constructed by the intratumor radiomics model combined with clinical and dosimetric parameters had AUC values of 0.928 (95%CI 0.879~0.966) and 0.765 (95%CI 0.692~0.831) in the training and validation sets, respectively.It has the best prediction efficacy.
Conclusion The Nomogram model based on the intratumoral radiomics features of pre-radiotherapy CT images, patient’s age, smoking, and pre-radiotherapy lymphocyte ratio combined with MLD and lung V20Gy has a better predictive accuracy for radiation pneumonitis in NSCLC, and it can be used as a quantitative model for the prediction of radiation pneumonitis in patients undergoing radiotherapy for NSCLC.
Using Normalization Process Theory to explore the contribution of stakeholder workshops to the development and refinement of a complex behavioural intervention: The STAMINA Lifestyle Intervention
Authors: Reale Sophie , Turner Rebecca R , Steed Liz , Taylor Steph J. C , Rosario Derek J , Bourke Liam , Morrissey Dylan , Innes Aidan Q , Sutton Eileen 
Published: January 2024

Abstract

Background
The National Institute for Health and Care Excellence (NICE) recommend that men with prostate cancer on androgen deprivation therapy (ADT) are offered twice weekly supervised aerobic and resistance exercise to address side effects of treatment. However, supervised exercise is not routinely offered in standard clinical practice. The STAMINA programme grant for applied research (PGfAR) has been designed to evaluate whether this recommendation can be delivered within standard NHS care. This paper describes how implementation of NICE recommendations within a trial context was explored during complex intervention development to enable evaluation of a lifestyle intervention.
Methods
Two stakeholder workshops were conducted to explore factors pertinent to future implementation of the STAMINA Lifestyle intervention (SLI). Normalisation Process Theory (NPT) provided the theoretical framework for discussion and analysis. Stakeholder workshop 1 focussed on intervention coherence and buy-in. Stakeholder workshop 2 explored strategies for embedding SLI into the context of the NHS with delivery partner Nuffield Health.
Results
Workshops were attended by healthcare professionals (n = 16), exercise professionals (n = 17), members of public involved in PPI (n = 12), health psychologists (n = 2), clinical commissioners (n = 4), cancer charities (n = 3), a cancer alliance (n = 1) and health economist (n = 1). Stakeholders agreed that professional training packages should emphasise the uniqueness of SLI and underpinning theory and evidence (Coherence). To further engagement, the use of STAMINA champions and information about the delivery partner were recommended to enhance confidence and knowledge (Cognitive participation). Furthermore, a simple communication (Collective Action) and progress reporting system (Reflexive Monitoring) was suggested to fit into existing infrastructure within the NHS and community partner.
Conclusions
Application of NPT within two stakeholder workshops optimised complex intervention development. Context-specific strategies to support implementation of the STAMINA Lifestyle Intervention within the context of a trial were proposed, sensed-checked, and considered acceptable. The organisational implications of embedding and sustaining the intervention in preparation for wider NHS roll-out were considered (if proven to be effective) and will be explored in the qualitative component of a process evaluation underpinned by NPT.
Trial registration
(ISRCTN: 46385239).
Longitudinal viral shedding and antibody response characteristics of men with acute infection of monkeypox virus: a prospective cohort study
Authors: Yang Yang , Yang Liuqing , Song Shuo , Shen Chenguang , Niu Siyu , Peng Yun , Xu Yifan , Shen Liang , GUO Liping , Liu Jiexiang , Zhang Shengjie , Chen Jiayin , Chen Si , Liao Zhonghui , Cui Yanxin , Huang Ting , Wang Fuxiang , Lu Hongzhou , Liu Yingxia 
Published: January 2024

Abstract

Background
Elucidating the viral and antibody dynamics within the host and the viral dynamics of the environmental fomits is key for the successful public health measures against monkeypox virus (MPXV) infection. In this study, a total of 993 samples from multiple sites of patients and 1,633 samples from environmental fomits of 77 acute MPXV infections (HIV co-infection: N=42) were collected every two to three days and subjected for the detection of MPXV DNA, surface proteins specific antibody and neutralizing titers. Overall, skin lesions showed 100% positive rate of MPXV DNA, followed by rectal swab (88.16%), saliva (83.78%), oropharyngeal swab (78.95%), urine (55.26%)and plasma (31.17%). Positive rate of oropharyngeal swab decreased rapidly after 7 days post symptoms onset (d.p.o), while the rectal swab and saliva maintained close positive rates to the skin lesions. Viral dynamics were similar among skin lesions, saliva and oropharyngeal, withrapid increase to the peak at about 6 d.p.o and then decreased. While for the rectal swab, it peaked at the beginning of symptoms onset, and decreased rapidly with the disease progression. Totally, 52.66% (860/1633) of environmental fomits swabs were positive for MPXV DNA, with highest positive rate (69.89%) and mean viral loads (Ct values of 31.22) from the deposition area. Moreover, the proportion of Ct values between 15-30 maintained high for some fomits like the deposition area, floor and bedside cupboard during the disease progression.High seropositivity against A29L (100%) and H3L (94.74%) were detected, while the high correlation was only found between anti-A29L IgG titer and neutralizing titer. Notably, most of indexes were similar between HIV and Non-HIV participants, except the higher viral loads in the early stage and peak viral from the rectal swabs of the HIV participants. Our results contribute to an improved understanding of viral shedding and antibody response characteristics of acute Mpox. With the ongoing outbreak of Mpox worldwide, these data have profound implications for the diagnosis, treatment, prevention of transmission and development of vaccines for Mpox.
Deep Learning Segmentation of Non-perfusion Area from Color Fundus Images and AI-generated Fluorescein Angiography
Authors: Masayoshi Kanato , Katada Yusaku , Ozawa Nobuhiro , Ibuki Mari , Negishi Kazuno , Kurihara Toshihide 
Published: January 2024

Abstract

The non-perfusion area (NPA) of the retina is an important indicator in the visual prognosis of patients with retinal vein occlusion (RVO). However, the current evaluation method of NPA, fluorescein angiography (FA), is invasive and burdensome. In this study, we examined the use of deep learning models for detecting NPA in color fundus images, bypassing the need for FA, and we also investigated the utility of synthetic FA generated from color fundus images. The models were evaluated using the Dice score and Monte Carlo dropout uncertainty. We retrospectively collected 403 sets of color fundus and FA images from 319 RVO patients. We trained three deep learning models on FA, color fundus images, and synthetic FA. As a result, though the FA model achieved the highest score, the other two models also performed comparably. We found no statistical significance in median Dice scores between the models. However, the color fundus model showed significantly higher uncertainty than the other models (p < 0.05). In conclusion, deep learning models can detect NPAs from color fundus images with reasonable accuracy, though with somewhat less prediction stability. Synthetic FA stabilizes the prediction and reduces misleading uncertainty estimates by enhancing image quality.
Recapitulation of human endochondral ossification by SOX9+ sclerotomal progenitors.
Authors: Li Zhonghan , Xiong Jingfei , Xie Kun , Chen Hanyi , Liao Yuansong , Deng Yanhui , Ma Runxin , Ye Guogen , Wang Yifu , Zhu Qing , Zhang Yunqiu , Yin Yike , Cai Haoyang , Guo Weihua 
Published: January 2024

Abstract
Endochondral ossification generates most of the load-bearing bones during skeletal development. Fully recapitulating it in human cells remains a challenge. Here, we established a toolkit to derive near uniform (>99%) SOX9+ sclerotomal progenitors (scl-progenitors), a key bipotent mesenchymal precursor at the pre-condensation stage, from human pluripotent stem cells and accompanying highly efficient osteochondral induction methods. Upon lineage-specific induction, SOX9+ scl-progenitors could not only regenerate articular cartilage but also undergo spontaneous condensation, cartilaginous anlagen formation, chondrocyte hypertrophy, vascular invasion, and finally bone formation with stroma, thus fully recapitulating the endochondral ossification. Moreover, self-organized growth plate-like structures could also be induced using SOX9+ scl-progenitor-derived fusion constructs with chondro- and osteo-spheroids, mimicking in vivo metaphysis. Furthermore, we identified ITGA9 as a specific surface marker to enable reporter-independent isolation of SOX9+ scl-progenitors and established a culture system to continuously expand them without compromising their osteochondral bipotential. Our work highlights SOX9+ scl-progenitors as a promising tool for modeling human skeletal development and bone/cartilage bioengineering.
Prophylactic cytoreductive surgery and hyperthermic intraperitoneal chemotherapy for low-grade appendiceal mucinous tumors with early and limited disease after completely removed
Authors: Wang Chong , Jia Yun , Shi Guanjun , An Lubiao , Fan Xiwen , Zhang Pu , Ma Ruiqing 
Published: January 2024

Abstract
Background
The necessity of prophylactic cytoreductive surgery (PCRS) and hyperthermic intraperitoneal chemotherapy (HIPEC) for low-grade appendiceal mucinous neoplasms (LAMN) after complete removal is still controversial. This study aims to determine the role of PCRS + HIPEC and identify optimal strategies for managing these patients.
Methods
One hundred and fifty-nine patients who sought medical advice at Aerospace Center Hospital were retrospectively analyzed from January 2011 to December 2021. All the patients were divided into the PCRS group and the observation group. The data of surgical specimens and pathology was collected, and the effect on recurrence-free survival (RFS) was analyzed.
Results
Of these 159 patients, 88 were in the PCRS group, and 71 were in the observation group. The median follow-up time was 38 months. Seven patients recurred and developed into pseudomyxoma peritonei, one in the PCRS group and six in the observation group. The median RFS in the PCRS group was significantly longer than the observation group (48.0 vs. 36.0, p = 0.002). The analysis of RFS showed that patients who underwent PCRS (p = 0.009 ) and HIPEC (p = 0.007) had better survival. After multivariate analysis, Surgical specimen accompanied by disseminated peritoneal adenocarcinoma was identified as an independent prognostic factor for RFS. In the study of surgical resection content, patients with greater omentum (p = 0.007) and bilateral fallopian tubes and ovaries of women (p = 0.002) resection had a more prolonged RFS with statistical significance.
Conclusion
Without higher-level evidence, PCRS and HIPEC are necessary for LAMN after complete removal in patients with a high risk of recurrence. We recommend removing at least the greater omentum and women's bilateral fallopian tubes and ovaries. For women who are unwilling to remove the bilateral fallopian tubes and ovaries, they should be fully informed of the risks.