bluuebunny/crossref_metadata_2025_split huggingface dataset:
Pancreatic cancer progression and mortality predicted by depression and anxiety: a systematic review and meta-analysis protocol
Authors: Zhang Ruoqi , Wang Jing , Zhang Peitong , Zhang Zheng , Miao Rui 
Published: January 2024

Although the relationship between psychological factors and pancreatic cancer outcomes has been widely discussed, controversy remains. We will for the first time systematically summarize the literature to explore the correlation of anxiety and depression to the prognosis of patients with pancreatic cancer. The findings will fill existing research gaps, informing healthcare providers about better psychological care and medical treatment. The following databases will be retrieved from their inception to July 2023: Cochrane Library, MEDLINE (PubMed), Web of Science, EMBASE, and four Chinese databases (Chinese National Knowledge Infrastructure, Wanfang Database, Chinese Biomedical Literature Database, and Chongqing VIP Chinese Science and Technology Periodical Database). The World Health Organization Clinical Trials Registry, Chinese Clinical Registry, and ClinicalTrials.gov will be searched to identify other related studies. A manual search will be performed to identify missing eligible studies based on the reference list of selected articles. The search will focus on studies published in Chinese or English. To assess the risk of bias in the selected articles, Newcastle-Ottawa Quality Assessment Scale (NOS) will be used for the cohort study. Funnel plots and Egger's test will be used to assess whether publication bias exists. Moreover, the Grading of Recommendations Assessment Development and Evaluation (GRADE) will be utilized to analyze the credibility of the results from selected articles. Two independent evaluators will implement the study selection and data extraction, as well as evaluate the risk of bias and evidence quality. Data will be analyzed using Stata 16.0.Trial registration: PROSPERO registration number is CRD42022366232.
Prescribed psychotropic medication patterns among treated Foster Care enrollees: a single institution study
Authors: Cosme Celica Glenn , Rudig Nathan O. , Borsellino Philip J. , Chea Deanna , Krider Reese I. , Durette Lisa 
Published: January 2024

BackgroundWhile several state-based studies have shown that children in foster care are more likely to be prescribed psychotropic medications and experience concomitant medication use both within and among medication class, these patterns have not been explored in the state of Nevada, which lacks state mandated oversight of psychotropic prescribing for foster care enrolled youth.MethodsData from an electronic medical record system from a single institution were analyzed to examine the prevalence of psychotropic prescribing and concomitant medication use in children ages 2 to 19 who were enrolled and received psychotropic prescriptions between July 2019 to June 2022.ResultsOut of 569 distinct psychotropic medication treatment episodes within this cohort, the most frequent psychotropic classes prescribed were non-stimulant ADHD medications (alpha-agonists and atomoxetine, 31.5%), atypical antipsychotics (22.1%), antidepressants (20.6%), and stimulants (16.0%). The use of stimulants and non-stimulant ADHD medications decreased in older age groups while the use of antidepressants and antipsychotics increased in older age groups. During the three-year period studied, 24.0% of psychotropic medications prescriptions increased in dosage. Treatments were prescribed for only one month in 43.8% of youth. In children prescribed psychotropic medications, concomitant medication use for at least 60 days occurred in 28.0% of children who had any psychotropic medication prescribed.ConclusionWithin the cohort of 273 foster care enrolled subjects aged 2 to 19 years old who received psychotropic medication prescriptions, non-stimulant ADHD medications (both alpha-agonists and atomoxetine) and atypical antipsychotics were more commonly co-prescribed additional psychotropic medication compared to other co-prescribed medication categories. This study illustrates prescribing patterns in a community mental health clinic focused on judicious prescribing of psychotropic medications in foster care enrolled youth. Despite this, 41% of the youth treated in this clinic received at least one prescription for psychotropic medication, and of those, 27.8% were prescribed more than one psychotropic medication at the same time. More studies are necessary to understand the underlying causes of high prevalence of concomitant medication use and prescribing practices of psychotropic medications use in foster care involved pediatric populations.
Cultural adaptation, content, and protocol of a feasibility study of school-based “Let’s learn about emotions” intervention for Finnish primary school children
Authors: Sourander A. , Ishikawa S. , Ståhlberg T. , Kishida K. , Mori Y. , Matsubara K. , Zhang X. , Hida N. , Korpilahti-Leino T. , Ristkari T. , Torii S. , Gilbert S. , Hinkka-Yli-Salomäki S. , Savolainen H. , Närhi V. 
Published: January 2024

IntroductionEmotional awareness and emotion regulation are crucial for cognitive and socio-emotional development in children. School-based interventions on socio-emotional skills have the potential to prevent these problems and promote well-being of children. The Japanese school-based program, Universal Unified Prevention Program for Diverse Disorders (Up2-D2), has shown preventive effects on mental health of children in Japan. The aims of this protocol paper are to describe the unique process of adapting the Up2-D2 from Eastern to Western context, and to present a feasibility study of the intervention, conducted in Finland.MethodsThe cultural adaptation process started with the linguistic translation of materials, followed by the modification of language to fit the Finnish context. While the Japanese ideology was saved, some content was adapted to fit Finnish school children. Further modifications were made based on feedback from pupils and teachers. The Finnish version of the program was named “Let’s learn about emotions” and consisted of 12 sessions and targeted 8- to 12-year-old pupils. A teacher education plan was established to assist Finnish teachers with the intervention, including a workshop, teachers’ manual, brief introductory videos, and online support sessions. A feasibility study involving 512 4th graders in the City of Hyvinkää, South of Finland, was conducted. It assessed emotional and behavioral problems, classroom climate, bullying, loneliness, perception of school environment, knowledge of emotional awareness, and program acceptability.DiscussionThe originality of this study underlies in the East–West adaptation of a cognitive behavioral therapy-based program. If promising feasibility findings are replicated in Finland, it could pave the way for further research on implementing such programs in diverse contexts and cultures, promoting coping skills, awareness, social skills and early prevention of child mental health problems.EthicsThe ethical board of the University of Turku gave ethics approval for this research. The educational board of the City of Hyvinkää accepted this study.
The influencing factors of participation in time banking volunteer service for older adults among university students in Nanjing, China
Authors: Wu Yue , Liu Siyu , Song Yating , Zhang Zhirui , Liu Yunlong 
Published: January 2024

ObjectiveThis study aims to identify factors influencing university students' participation in time banking volunteer services for older adults and provides evidence to promote the involvement.MethodsConducted in November 2022, we utilized a convenience sampling method to recruit students from the School of Aging Service and Management at Nanjing University of Chinese Medicine, China. Data was collected through an online questionnaire focusing on various aspects related to time banking volunteer services for older adults. Factor analysis was employed to extract variables, and logistic regression was applied to identify key determinants.ResultsA significant majority (82.67%) of participants expressed willingness to engage in volunteer services for older adults. Factor analysis uncovered six influential factors explaining 62.55% of the variance. Logistic regression highlighted four key determinants of students' willingness: value judgment (OR = 4.392, CI = 2.897–6.658), social support (OR = 1.262, CI = 0.938–1.975), social influence (OR = 1.777, CI = 1.598–3.799), and socioeconomic conditions (OR = 1.174, CI = 1.891–3.046).ConclusionTo foster sustainability and continuous time banking among university students majoring in aging service and management, a multifaceted support involving governmental, social, and university is recommended.
Does environmental regulation lessen health risks? Evidence from Chinese cities
Authors: Xu Qingqing , Wang Liyun , Hou Hanxue , Han ZhengChang , Xue Wenhao 
Published: January 2024

IntroductionAtmospheric pollution is a severe problem confronting the world today, endangering not only natural ecosystem equilibrium but also human life and health. As a result, governments have enacted environmental regulations to minimize pollutant emissions, enhance air quality and protect public health. In this setting, it is critical to explore the health implications of environmental regulation.MethodsBased on city panel data from 2009 to 2020, the influence of environmental regulatory intensity on health risks in China is examined in this study.ResultsIt is discovered that enhanced environmental regulation significantly reduces health risks in cities, with each 1-unit increase in the degree of environmental regulation lowering the total number of local premature deaths from stroke, ischemic heart disease, and lung cancer by approximately 15.4%, a finding that remains true after multiple robustness tests. Furthermore, advances in science and technology are shown to boost the health benefits from environmental regulation. We also discover that inland cities, southern cities, and non-low-carbon pilot cities benefit more from environmental regulation.DiscussionThe results of this research can serve as a theoretical and empirical foundation for comprehending the social welfare consequences of environmental regulation and for guiding environmental regulation decision-making.
Dietary trends and obesity in Saudi Arabia
Authors: Alhusseini Noara , Alsinan Nawra , Almutahhar Shahad , Khader Majd , Tamimi Rawand , Elsarrag Mazin Ibrahim , Warar Rabah , Alnasser Sara , Ramadan Majed , Omair Aamir , Aouabdi Sihem , Saleem Rimah , Alabadi-Bierman Alaa 
Published: January 2024

IntroductionDietary habits in Saudi Arabia have been shifting toward the Western diet, which is high in fat, salt, and sugar, leading to a high obesity rate. Different dietary strategies such as the Ketogenic Diet (KD), Intermittent Fasting (IF), Gluten Free Diet (GFD), and Calorie Restriction Diet (CRD) have shown an influential role in weight loss. This study aimed to compare trending diets and correlate different types of diet with obesity and lifestyle among adults in Saudi Arabia.MethodsA cross-sectional study was performed on Saudis and non-Saudis over 18 years old. We used convenience sampling, an online questionnaire distributed via social media channels, including WhatsApp, LinkedIn, and Twitter. SPSS 28 software was applied for data analysis. The chi-square test was used to determine associations between different variables. Statistical significance was considered at a value of p less than 0.05.ResultsMost participants were females residing in the Eastern and Central regions of Saudi Arabia. Although most do not follow any dietary plan, they exhibited acceptable exercise and lifestyle. The minority of the study population followed different types of diet plans, such as KD, IF, and GFD. The purpose of most of the participants who have used these strategies was for weight loss but failed to sustain the dietary plan for more than 1 month.ConclusionObesity remains a challenging issue in Saudi Arabia. Adherence to dietary regimes could help in controlling obesity. Increasing the awareness of the benefits of each dietary plan for health, choosing the appropriate one, and sustaining a balanced nutrition pattern.
Implementing a social innovation for community-based peer support for immigrant mothers in Sweden: a mixed-methods process evaluation
Authors: Kåks Per , Stansert Katzen Linnea , Målqvist Mats , Bergström Anna , Herzig van Wees Sibylle 
Published: January 2024

IntroductionA South African social innovation based on peer support for mothers was contextualized in southern Sweden. The objective of the project was to support expectant women and mothers of young children in immigrant communities to access public services that would benefit maternal and child health. This study aimed to assess how the intervention was implemented, what the contextual barriers and facilitators were, and how the implementation was perceived by those who delivered and received it.MethodsThe study used mixed methods with a convergent parallel design and followed the Medical Research Council guidance on process evaluations of complex interventions. Semi-structured interviews (n = 19) were conducted with peer supporters, client mothers, and key stakeholders involved in the intervention. The qualitative data were analyzed using content analysis. Quantitative data on peer supporters' activities were collected during contacts with client mothers and were presented descriptively.ResultsThe five peer supporters had 1,294 contacts with client mothers, of which 507 were first-time contacts. The reach was perceived as wide, and the dose of the intervention was tailored to individual needs. Barriers to implementation included community mistrust of social services, norms on gender roles and parenting, and funding challenges. The implementation was facilitated by the organization's reputation, network, experience, and third-sector affiliation. Peer supporters tended to prioritize linking clients to other services over the educational components of the intervention, sometimes doing more than what was originally planned. Implementation strategies used included building trust, using multiple outreach venues, using internal support structures, and providing practical assistance as an entry point to comprehensive psychosocial support. The personal connection between peer supporters and clients was highly valued, and the building of relationships enabled them to address sensitive topics. Peer supporters sometimes experienced a blurred line between professional and personal roles.ConclusionsPeer supporters used a variety of strategies to navigate identified barriers and facilitators. Trust was central both as a contextual factor and a strategy for implementation. It is valuable to maintain a balance between flexibility and adherence to the function of peer supporters. Further research is needed to evaluate the effects of the intervention.
Impact of a mobile health intervention based on multi-theory model of health behavior change on self-management in patients with differentiated thyroid cancer: protocol for a randomized controlled trial
Authors: Jiang Yang , Sun Xiangju , Jiang Maomin , Min Hewei , Wang Jing , Fu Xinghua , Qi Jiale , Yu Zhenjie , Zhu Xiaomei , Wu Yibo 
Published: January 2024

IntroductionTheoretical models of health behavior are important guides for disease prevention and detection, treatment and rehabilitation, and promotion and maintenance of physical and mental health, but there are no intervention studies related to differentiated thyroid cancer (DTC) that use theoretical models of health as a guide. In this study, we used a microblogging platform as an intervention vehicle and mobile patient-doctor interactive health education as a means of intervention, with the aim of improving the health behaviors of DTC patients as well as the corresponding clinical outcomes.MethodsThis research project is a quantitative methodological study, and the trial will be a single-blind, single-center randomized controlled trial conducted at the Fourth Hospital of Harbin Medical University in Harbin, Heilongjiang Province. The study subjects are patients over 18 years of age with differentiated thyroid cancer who were given radioactive iodine-131 therapy as well as endocrine therapy after radical surgery for thyroid cancer. The intervention group will receive MTM-mhealth, and the realization of health education will rely on the smart terminal WeChat platform. Routine discharge education will be given to the control group at discharge. The primary outcome will be change in thyroid-stimulating hormone (TSH) from baseline and at 3 and 6 months of follow-up, and secondary outcomes will include change in self-management behavior, social cognitive and psychological, and metabolic control.DiscussionThis study will explore a feasible mHealth intervention program applied to a population of DTC patients using the Multi-theory model of health behavior change (MTM) as a guide, with the aim of evaluating the MTM-based intervention program for clinical outcome improvement in DTC patients, as well as determining the effectiveness of the MTM-based intervention program in improving self-management skills in DTC patients. The results of this study will indicate the feasibility as well as the effectiveness of the application of health theoretical modeling combined with mHealth applications in disease prognostic health management models, and provide policy recommendations and technological translations for the development of mobility-based health management applications in the field of health management.
Steroid hormones as a non-lethal assessment of the reproductive biology in male and female blacktip reef sharks
Authors: Mourier Johann , Planes Serge , Mills Suzanne C. 
Published: January 2024

IntroductionOverexploitation of sharks and the destruction of their habitat has led to severe population declines and the need for conservation and management actions. Effective conservation management requires knowledge of the size at which a shark matures and an understanding of their breeding season, fundamental information to maintain appropriate population levels.MethodsHere we used reproductive endocrinology, estrogen and androgen steroids, in combination with rare direct observations of mating, visual monitoring of reproductive status such as gestation and mating scars, as well as parentage analysis, to assess reproductive biology in male and female Chondrichthyans from the wild.Results and discussionLengths at sexual maturity of female and male blacktip reef sharks corresponded closely with plasma 17β-estradiol, testosterone and 11-ketotestosterone measures respectively, but we found considerable variation in androgen levels for mature males. Size at sexual maturity of male and female blacktip reef shark deduced from direct or indirect evidence (mating scars or parentage assignment respectively, corresponded closely with plasma 17β-estradiol, testosterone and 11-ketotestosterone measures respectively, but we found considerable variation in androgen levels for mature males. Females attained sexual maturity from around 121 to 123 cm and males from 104 to 111 cm. The mating season extends from September to February but female 17β-estradiol levels are elevated 1 month prior to mating. Endocrinology has brought additional important information to the reproductive biology and ecology of blacktip reef sharks.
A comparison of the effects of sheep's milk and cow's milk on recovery from eccentric exercise
Authors: Ravenwood Ben , Coad Jane , Barnes Matthew J. 
Published: January 2024

IntroductionWhen consumed after eccentric exercise, cow's milk has been shown to improve recovery and alleviate symptoms of exercise induced muscle damage. Although currently less commercially available than cow's milk, sheep's milk may offer similar or greater benefits for recovery as it is higher in protein and energy; however, the effect of sheep's milk in any exercise context has not been explored. This study compared the effects of a sheep's milk beverage and a cow's milk beverage on recovery from strenuous eccentric exercise. Additionally, the effects of each beverage on satiety and gastrointestinal comfort were assessed.MethodsTen healthy males completed baseline measures of perceived muscle soreness and maximal voluntary concentric, eccentric, and isometric quadriceps force of one leg before completing 200 maximal eccentric knee extensions on an isokinetic dynamometer. Measures were repeated 0.5, 24, 48 and 72 h post-eccentric exercise. After 0.5 h measures, participants consumed either 450 ml of chocolate flavored sheep's milk or chocolate flavored cow's milk. Following a washout period, participants completed a second trial on the contralateral leg and consumed the other beverage. Additionally, a satiety and gastrointestinal comfort questionnaire was completed before and after each beverage was consumed.ResultsEccentric exercise brought about a significant decrease in muscle function over time (all P &lt; 0.012). No difference between treatments (all P &gt; 0.097) was found. Measures of muscle soreness increased over time (all P &lt; 0.002), however no difference was observed between treatments (all P &gt; 0.072). Only sheep's milk altered perceived satiety, however, only the response to “How full do you feel” differed between treatments (P = 0.04).DiscussionThe results of this study suggest that consuming sheep's milk may provide similar benefits as cow's milk when recovering from exercise-induced muscle damage. While these findings provide initial support for the use of sheep's milk in a muscle recovery context, further research is warranted to confirm these findings. Given its superior nutritional profile, greater impact on satiety and lower environment impact, sheep's milk may be a more efficient post-exercise recovery beverage, compared to cow's milk.
Evaluación Integral de la Solidez Financiera en el Sector Hotelero Español: Un Enfoque Estructural y Comparativo
Authors: León-Gómez Ana , Gimeno-Arias Fernando , García-Revilla Mercedes Raquel , Mora Forero Jorge Alexander 
Published: January 2024

El desarrollo de este trabajo de investigación se realizó con el fin de encontrar la incidencia que España, un actor destacado en el turismo mundial, ha experimentado una notable transformación en su sector turístico, evolucionando de un enfoque centrado en sol y playa hacia una oferta más rica que incluye atractivos culturales y gastronómicos. En este contexto, el sector hotelero se ha consolidado como un elemento crucial de la industria, impulsando la inversión, el empleo y la innovación. Este estudio se enfoca en el análisis del sector hotelero español para proporcionar una comprensión profunda de su impacto económico. Se examina la evolución del sector en términos de capacidad financiera, rentabilidad y generación de empleo, empleando un análisis detallado de indicadores clave y un enfoque económico-financiero. Con este fin, se han implementado dos análisis fundamentales: primero, un estudio longitudinal de las principales ratios financieras, que ofrece una perspectiva de la evolución y tendencias a lo largo del tiempo. Segundo, se realiza un análisis económico-financiero exhaustivo, diseñado para evaluar en profundidad la solidez y estabilidad financiera del sector hotelero. La investigación contempla una variedad de factores, tanto internos como externos, que influyen en la rentabilidad del sector, incluyendo la situación macroeconómica, las políticas gubernamentales y variables como la ubicación y la innovación. Los resultados muestran que, aunque el sector hotelero español exhibe una fuerte capacidad empresarial, enfrenta retos significativos en términos de solvencia y apalancamiento. El estudio concluye subrayando la importancia de desarrollar estrategias eficientes para mejorar la rentabilidad y la solidez financiera del sector, ofreciendo un análisis detallado de los indicadores económicos.