bluuebunny/crossref_metadata_2025_split huggingface dataset:
IVIg Use Associated with Ten-Fold Reduction of Serious Infections in Multiple Myeloma Patients Treated with Anti-BCMA Bispecific Antibodies
Authors: Lancman Guido , Parsa Kian , Kotlarz Krzysztof , Avery Lisa , Lurie Alaina , Lieberman-Cribbin Alex , Cho Hearn Jay , Parekh Samir S. , Richard Shambavi , Richter Joshua , Rodriguez Cesar , Rossi Adriana , Sanchez Larysa J. , Thibaud Santiago , Jagannath Sundar , Chari Ajai 
Published: September 2023

Abstract

BCMA-targeted bispecific antibodies (BiAb) are efficacious in relapsed/refractory multiple myeloma; however, serious infections have emerged as important toxicities. In this retrospective study, we characterized all infections and their risk factors, and evaluated the impact of infection prophylaxis in patients treated with BCMA-targeted BiAbs. Among 37 patients, 15 (41%) experienced a grade 3–5 infection, with two infection-related deaths during deep remissions. Most (84%) infections occurred during disease remissions. The cumulative probability of grade 3–5 infection increased over time with no plateau. Among responders (n = 26), profound hypogammaglobulinemia occurred in 100% and continued throughout the entire duration of treatment. During periods when patients were receiving intravenous immunoglobulin (IVIg), the rate of grade 3–5 infections was 90% lower than during observation (incidence rate ratio, 0.10; 95% confidence interval, 0.01–0.80; P = 0.0307). No other risk factors for infection were identified. This study demonstrates that profound hypogammaglobulinemia is universal with BCMA-targeted BiAbs, with intravenous immunoglobulin potentially abrogating most of the infection risk.

Significance:
To the best of our knowledge, this is the first study to comprehensively analyze risk factors and mitigation strategies to prevent infections in myeloma patients receiving anti-BCMA bispecific antibodies. Profound and prolonged hypogammaglobulinemia was universal among responders, while immunoglobulin replacement was associated with 90% lower rates of grade 3–5 infections.
See related commentary by Garfall and Stadtmauer, p. 427 .
This article is featured in Selected Articles from This Issue, p. 419
Novel Metabolites Are Associated With Thrombosis After Cardiac Surgery in Children With Congenital Heart Disease
Authors: Li Shengxu , Watson Dave , Jorgenson Alissa , Adelekan Zainab , Tang Weihong , Garland Kathleen , Zupancich Leah , Dassenko David , Edens R. Erik , Overman David M. , Huntley Marnie T. 
Published: September 2023

BACKGROUND:
Thrombosis is a major complication after cardiac surgery in children with congenital heart disease. The mechanisms underlying thrombosis development remain poorly understood. We aimed to identify novel circulating metabolites before cardiac surgery that are associated with thrombosis after surgery in children with congenital heart disease.

METHODS:
In this prospective cohort study, all blood samples were drawn right before surgical incision and after the induction of anesthesia, and plasma was separated immediately under 4 °C. Untargeted metabolomic data were measured by Metabolon in plasma from children (age range, 0 days–18 years) with congenital heart disease undergoing cardiac surgery. The primary outcome was thrombosis within 30 days of surgery or before discharge. Associations of individual metabolites with thrombosis were assessed with logistic regression with false discovery rate correction for multiple comparison and adjustment for clinical characteristics; elastic net regression was used to select a prediction model.

RESULTS:

Out of 1115 metabolites measured in samples from 203 children, 776 met the quality control criteria. In total, 25 children (12.3%) developed thrombosis. Among the 776 metabolites, 175 were significantly associated with thrombosis (false discovery rate
Q
<0.05). The top 3 metabolites showing the strongest associations with thrombosis were eicosapentaenoate, stearidonate, and andro steroid monosulfate C
19
H
28
O
6
S (false discovery rate, 0.01 for all). Pathway analysis showed that the pathways of nicotinate and nicotinamide metabolism and glycerophospholipid metabolism were enriched (false discovery rate, 0.003 for both) and had significant impact on the development of thrombosis. In elastic net regression analysis, the area under the receiver operating-characteristic curve of a prediction model for thrombosis was 0.969 in the training sample (70% of the total sample) and 0.833 in the testing sample (the remaining 30%).

CONCLUSIONS:
We have identified promising novel metabolites and metabolic pathways associated with thrombosis. Future studies are warranted to confirm these findings and examine the mechanistic pathways to thrombosis.
Shocked or Satiated? Managing Moral Shocks Beyond the Recruitment Stage
Authors: Wrenn Corey Lee 
Published: September 2023

Abstract
Sociologists James Jasper and Jane Poulsen have argued that activists’ deployment of emotionally triggering ‘moral shocks’ can stimulate recruitment for movements, particularly for those which are less successful in recruiting through social networks. Others have suggested that, more than a recruitment tool, these moral shocks are useful for sustaining activist motivation. This study, however, explores the tendency of activists to disengage from moral shocks as a means of managing emotions such as compassion fatigue, burnout and psychological distress. Although many respondents see the utility in moral shocks as an outreach tool, they carefully consider their own exposure to protect their emotional well-being and protest sustainability. Results are based on an email-based qualitative interview with twenty-five newly recruited activists and established activists in the Western Nonhuman Animal rights movement.
The Making of Classics: Li Bai and Du Fu’s Poems in Anthologies of Tang Poetry between the Tang and the Ming Dynasties
Authors: Ding Fang 
Published: September 2023

Abstract
The canonization of Li Bai and Du Fu’s poetry occurred over a period that spanned centuries and dynasties. The treatment of Li Bai and Du Fu’s works differed through the ages. Among anthologies from the Tang and the Five Dynasties that remain to our disposition today, only three contain poems by Li Bai, and only one includes some by Du Fu. Tang compilers had a poor opinion of the two poets. Their criticism contrasts substantially with the praise that was offered by Han Yu and other poets. During the Song and Yuan dynasties, scholars held Li Bai and Du Fu in high regard, yet their poems were often omitted by compilers. The main reason for this exclusion was that both poets’ complete works had long been considered unworthy and set aside. Compilers respected the skills of the two poets, but they did not truly appreciate their work. During the Ming dynasty, anthologies would comment on the two poets as important figures of literary history. Compilers praised their art as being of the highest quality. By then, both poets were highly respected, and their poems had officially already been made into classics. In the process of becoming classics, works of art can be seen as enduring, and as cumulating value through different periods of time. Times keep on changing, yet the significance of Li Bai and Du Fu’s poetry became all the more obvious as centuries passed.
The Canonization of Du Fu in the Context of East Asian Literature
Authors: Zhang Bowei 
Published: September 2023

Abstract
In such regions of the East Asian cultural sphere as China, Korea and Japan, the canonization of Du Fu was a relatively lengthy process. It was achieved mainly because of strong support from three different cohorts: the first cohort is the Chinese literary giants who expressed strong commendations of Du Fu, the second cohort is the Japanese scholars who conducted rigorous evaluation of Du Fu’s poetry within academic frameworks, and the third cohort is the Korean royals who directly contributed to the rise of Du Fu’s poetry. The first two cohorts are unofficial, while the latter one is official but not without amicable interactions with the masses. Korean literature was in tune with the character of Du Fu’s poetry because it displayed a strong tendency towards politics; Japanese literature, on the other hand, was somewhat not, for it hardly included coverage on issues of social politics. Du Fu was given the highest literary recognition in both Korea and Japan for his poetic prowess, and his poetry was used by the state in both regions to serve different purposes; this goes to demonstrate that the two countries made their own culturally-driven decisions when accepting the influence of Chinese culture. It is a norm in East Asian literature for literary canons, whether old or new, to coexist, regardless of type or level, and such a norm is particular to the admission of literary works into literary canons within the East Asian cultural sphere.
Stories of Surveillance and Resistance: Young People with Dwarfism and Teaching Assistants in Secondary Schools in the United Kingdom
Authors: Ktenidis Antonios 
Published: September 2023

Abstract
Teaching Assistants (ta s) are described as key figures in the inclusion of disabled young people in mainstream schools. However, disabled young people’s insights into ta s’ support remain limited. This paper contributes to such insights by exploring the experiences of young people with dwarfism in secondary education with their ta s in the United Kingdom, drawing on their qualitative, first-hand accounts. I engage in a Foucauldian analysis of ta s’ support, where I argue that, under the guise of support, disabled young people sustain ta s’ panoptic surveillance, aiming at their normalisation. Nevertheless, the stories reveal modes of surveillance that go beyond panopticism, such as panauralism. Moreover, the stories demonstrate how young people resist to their surveillance by re-turning the gaze to their ta s, exercising the synoptic gaze. The paper concludes by considering the contributions of those stories, including the need to consider surveillance in relational terms, its multi-sensory nature, and its constitutive power.
Over-indebtedness in Microfinance: Evidence From a Survey of Borrower Households From an Indian State
Authors: Puliyakot Sunil , Pradhan H. K. 
Published: September 2023

Based on a household survey of 210 borrowing households from the state of Tamil Nadu, India, we investigate the extent and determinants of over-indebtedness among microfinance borrowers. Our analysis based on logistic regression framework using three distinct measures of over-indebtedness shows that the extent of over-indebtedness among the borrowing households is relatively widespread. As regards the determinants, apart from the demographic factors, external and lender-related factors contribute more towards over-indebtedness rather than borrower-related factors. Within the lender-related factors informal sources of credit exert a much stronger influence on over-indebtedness than formal sources which includes microfinance. The above findings imply that the policy environment should facilitate easier access to formal sources such as microfinance, along with provision of social security schemes with a minimum guaranteed income and insurance coverage. JEL Codes: C93, C51, D14, D92, I31
The Nexus Between Information Asymmetry and Liquidity of Stock: Evidence from the Indian Market
Authors: Dutta Shubha Ranjan , Sen Som Sankar , Mukherjee Tutun 
Published: September 2023

This study intended to explore the influence of informational asymmetry on stock liquidity in India. After controlling for the effects of firm-specific risk and investor sentiment, the results show that informational asymmetry, as measured by the delay factors has a significant positive association with illiquidity, indicating that market liquidity decreases with less transparency and a high level of informational asymmetry. The results also show that investor sentiment has a significant association with illiquidity, whereas firm-specific risk and illiquidity seem to have no noticeable relationship. The empirical results are validated using a dynamic panel-data approach, with two-stage GMM and remain robust. Theoretically, this study extends the existing literature on liquidity by offering new evidence from a prospective market like India. In practical terms, the findings of this study would help the stock exchange regulators and other regulatory bodies to strengthen the process of information dissemination and sensitise market participants and investors by maintaining a smooth flow of information. JEL Codes: G11, G12, G4, G32
Parents’ Trust in COVID-19 Messengers and Implications for Vaccination
Authors: Klein Lauren M. , Habib Daniel R. S. , Edwards Lorece V. , Hager Erin R. , Berry Andrea A. , Connor Katherine A. , Calderon Gabriela , Liu Yisi , Johnson Sara B. 
Published: September 2023

Purpose To characterize factors associated with parents’ trust in messengers of COVID-19 guidance and determine whether trust in their doctors is associated with COVID-19 vaccination. Design Web-based and mailed survey (January-June 2022). Setting Maryland, USA. Subjects 567 parents/caregivers of public elementary and middle school students. Measures Parents rated trust in 9 messengers on a 4-point scale [“not at all” (0) to “a great deal” (3)], dichotomized into low (0-1) vs high (2-3). They reported on health insurance, income, race, ethnicity, education, sex, urbanicity, political affiliation, and COVID-19 vaccination. Analysis ANOVA and t-tests were computed to compare overall trust by parent characteristics. Multivariable logistic regression was run to evaluate factors associated with high trust for each messenger. Multivariable logistic regression was used to evaluate the relationship between trust in doctors and odds of COVID-19 vaccination. Results Most trusted messengers were doctors (M = 2.65), family members (M = 1.87), and schools (M = 1.81). Parents’ trust varied by racial identity, sex, urbanicity, health insurance, and political affiliation. Greater trust in their or their child’s doctor was associated with greater odds of child (aOR: 2.97; 95% CI: 1.10, 7.98) and parent (aOR: 3.30; 95% CI: 1.23, 1.47) vaccination. Conclusion Parent characteristics were associated with trust, and trust was linked to vaccination. Public health professionals should anticipate variability in trusted messengers to optimize uptake of public health guidance.
The synergistic effects of micro-and nano-fillers on the properties of polyamide 11/poly (lactic acid) blend
Authors: Üçpinar Durmaz Bedriye , Aytac Ayse 
Published: September 2023

This study focused on investigating the effects of micro-scale carbon fibers (CF) and nano-scale graphene nanoplatelets (GNP) on the morphological, rheological, mechanical, thermo-mechanical and thermal properties of polyamide 11/poly (lactic acid) (PA11/PLA) blend. A twin-screw extruder and an injection molding machine were utilized to produce the samples. The amount of GNPs was varied up to 5 wt% for a fixed CF fraction of 20 wt%, and the composites were characterized. SEM micrographs of hybrid composites revealed stronger interfacial interactions between the matrix and CF and improved dispersion of GNPs. The pseudo solid-like behavior transition and high modulus detected in the rheological study with the addition of GNP confirmed the strong matrix-filler interactions in hybrid composites. The synergistic effects of multi-scale fillers have been observed in mechanical and thermo-mechanical properties. In comparison to 20CF, hybrid composites’ tensile strength and modulus increased by 8%–4.8% and 4.5%–17%, respectively, by adding 0.5–5 wt% GNP. Dynamic mechanical analysis revealed that the tan δ peak shifted to higher temperatures in low GNP containing hybrid composites, indicating an increase in Tg. Also, differential scanning calorimetry confirmed the Tg increment and synergistic effect of fillers on crystallization. The thermogravimetric analysis demonstrated that hybrid composites exhibited enhanced thermal stability. As a consequence, these hybrid composites offer an inventive viewpoint for environmentally friendly composites in the automobile industry thanks to their enhanced mechanical and thermal characteristics.
Preclinical Safety Evaluation of the Human-Identical Milk Oligosaccharide Lacto-N-Triose II
Authors: Fang Xu , Zhu Wei , Zhao Huiying , Yin Wencheng , Song Xiao , Liu Fengxin 
Published: September 2023

Lacto-N-triose II (LNT II), an essential human milk oligosaccharide and precursor to lacto-N-tetraose (LNT) and lacto-N-neotetraose (LNnT), was evaluated for safety. Genotoxicity was assessed through in vitro tests including Bacterial Reverse Mutation Test and mammalian cell micronucleus test, and a subchronic oral gavage toxicity study was conducted on juvenile Sprague-Dawley rats. In this study, LNT II was administered at dose levels of 0, 1,500, 2,500, or 5,000 mg/kg body weight (bw)/day for 90 days, followed by a 4-week treatment-free recovery period. LNT II was non-genotoxic in the in vitro assays. No compound-related effects were observed across all dosage levels based on various measures, including clinical observations, body weight gain, feed consumption, clinical pathology, organ weights, and histopathology. Consequently, the highest dosage of 5,000 mg/kg bw/day was established as the no-observed-adverse-effect-level (NOAEL). These results suggest the safe use of LNT II in young children formula and as a food ingredient, within the limits found naturally in human breast milk.
The effect of distal aspiration catheter position on collateral flow in mechanical thrombectomy – an in vitro study
Authors: Jakobek William , Gravino Gilbert , Nayak Sanjeev , Yang Ying , Ranjbar Jacob , Roffe Christine 
Published: September 2023

Introduction Endovascular mechanical thrombectomy for ischaemic stroke is one of the most effective treatments. Despite the devices and techniques that have been developed, thrombi are not always successfully retrieved. The incidence of futile reperfusion after successful clot retrieval also remains a major concern. We hypothesise that simply placing an aspiration catheter in the system compromises collateral flow which may have an impact on functional outcomes. Methods An in vitro study was conducted using a physical pulsatile flow model designed in glass to mimic the anterior cerebral circulation with middle cerebral artery M1 segment occlusion. A 5Fr aspiration catheter was positioned at the supra-clinoid internal carotid (SC-ICA), carotid terminus (T-ICA) and M1. For each catheter position, the flow rate through the model's anterior cerebral (ACA) and posterior communicating (PCOM) arteries was measured (no aspiration applied). Results Our results showed significant mean percentage flow reductions in the ACA and PCOM with the catheter positioned at the SC-ICA (PCOM 59.14% ± 0.93, ACA 59.52% ± 0.82, p < 0.001), T-ICA (PCOM 81.54% ± 0.55, ACA 85.65% ± 1.54) and M1 (PCOM 75.79% ± 0.98, ACA 84.20% ± 0.43) (Mann–Whitney U Test, p < 0.001). Conclusion These results indicate a significant reduction in collateral flow following the insertion of a wide bore catheter in an in vitro model. In a clinical setting, this could have an impact on patient outcome, particularly in prolonged procedures and those requiring several passes to achieve recanalisation.
Autologous haematopoietic stem cell transplantation for multiple sclerosis: a position paper and registry outline
Authors: Bayas Antonios , Berthele Achim , Blank Norbert , Dreger Peter , Faissner Simon , Friese Manuel A. , Gerdes Lisa-Ann , Grauer Oliver Martin , Häussler Vivien , Heesen Christoph , Janson Dietlinde , Korporal-Kuhnke Mirjam , Kowarik Markus , Kröger Nikolaus , Lünemann Jan D. , Martin Roland , Meier Uwe , Meuth Sven , Muraro Paolo , Platten Michael , Schirmer Lucas , Stürner Klarissa Hanja , Stellmann Jan Patrick , Scheid Christof , Bergh Florian Then , Warnke Clemens , Wildemann Brigitte , Ziemssen Tjalf 
Published: September 2023

Background: While substantial progress has been made in the development of disease-modifying medications for multiple sclerosis (MS), a high percentage of treated patients still show progression and persistent inflammatory activity. Autologous haematopoietic stem cell transplantation (AHSCT) aims at eliminating a pathogenic immune repertoire through intense short-term immunosuppression that enables subsequent regeneration of a new and healthy immune system to re-establish immune tolerance for a long period of time. A number of mostly open-label, uncontrolled studies conducted over the past 20 years collected about 4000 cases. They uniformly reported high efficacy of AHSCT in controlling MS inflammatory disease activity, more markedly beneficial in relapsing-remitting MS. Immunological studies provided evidence for qualitative immune resetting following AHSCT. These data and improved safety profiles of transplantation procedures spurred interest in using AHSCT as a treatment option for MS. Objective: To develop expert consensus recommendations on AHSCT in Germany and outline a registry study project. Methods: An open call among MS neurologists as well as among experts in stem cell transplantation in Germany started in December 2021 to join a series of virtual meetings. Results: We provide a consensus-based opinion paper authored by 25 experts on the up-to-date optimal use of AHSCT in managing MS based on the Swiss criteria. Current data indicate that patients who are most likely to benefit from AHSCT have relapsing-remitting MS and are young, ambulatory and have high disease activity. Treatment data with AHSCT will be collected within the German REgistry Cohort of autologous haematopoietic stem CeLl trAnsplantation In MS (RECLAIM). Conclusion: Further clinical trials, including registry-based analyses, are urgently needed to better define the patient characteristics, efficacy and safety profile of AHSCT compared with other high-efficacy therapies and to optimally position it as a treatment option in different MS disease stages.