bluuebunny/crossref_metadata_2025_split huggingface dataset:
Case Report: The Versatile Art of Reconstruction: A Decade‐Long Journey With Recurrent Facial Basal Cell Carcinoma
Authors: Pathirana T. H. , Bandaranayake V. , Nellihela A. P. , Nikeshala S. , Saranga T. , Abegunasekara A. , Gunathilake S. , Asanthi N. J. 
Published: January 2025

ABSTRACTBackgroundBasocellular carcinoma (BCC) is the most prevalent skin malignancy, often localizing to the UV‐exposed skin of the face. While most BCC is relatively indolent, aggressive subtypes, including infiltrative BCC, pose the treatment challenges of ensuring functional and aesthetic preservation with a high risk of recurrence.CaseA 78‐year‐old female patient complained of recurrent left chin BCC of infiltrative subtype, which was first treated in 2013 by wide local excision and adjuvant radiotherapy. Recurrent carcinoma was reported in 2017, 2021, and most recently in 2023. The most recent recurrence presented with scar contracture, facial asymmetry, and drooping of the lip. Surgical resection involved extensive excision of the lower lip and chin, exposing the mandible. Reconstruction was achieved with the help of bilaterally designed Karapandzic flaps for the lip and a bilobed rotational flap for the chin defect. Although no chemotherapy and immunotherapy were given, the functional and aesthetic result were satisfactory. The procedure was executed while preserving the pertinent neurovascular structures, maintaining oral competence, and restoring the lower face. The Karapandzic flap was helpful in maintaining the lip function, whereas the chin was reconstructed using the bilobed rotational flap. Post‐operative histology confirmed the diagnosis of BCC with squamous differentiation, which had clear margins. The patient did well and the cosmetic and functional outcome was satisfactory without any disease at 18 months after surgery.ConclusionThis case sheds light on the difficulties encountered in treating recurrent facial BCC in developing countries. In the absence of systemic therapies, advanced surgical techniques and intensive follow‐up resulted in a long disease‐free period with good functional and aesthetic outcomes, thanks to the successful use of innovative reconstruction even in a low‐resource setting.
Lessons Learned on Obtaining Reliable Dynamic Properties for Ionic Liquids
Authors: Frömbgen Tom , Zaby Paul , Alizadeh Vahideh , Da Silva Juarez L. F. , Kirchner Barbara , Lourenço Tuanan C. 
Published: January 2025

AbstractIonic liquids are nowadays investigated with respect to their use as electrolytes for high‐performance energy storage materials. In this study, we provide a tutorial on how to calculate dynamic properties such as self‐diffusion coefficients, ionic conductivities, transference numbers, as well as ion pair and ion cage dynamics, that all play a role in judging the applicability of ionic liquids as electrolytes. For the case of the ionic liquid
, we investigate the performance of different force fields. Amongst them are non‐polarizable models employing unity charges, a charge‐scaled version of a non‐polarizable model, a polarizable model and another non‐polarizable model with refined Lennard‐Jones parameters. We also study the influence of the system size on the dynamic properties. While all studied force field models capture qualitatively correct trends, only the polarizable force field and the non‐polarizable force field with refined Lennard‐Jones parameters provide quantitative agreement to reference data, making the latter model very attractive for the reason of lower computational costs.
Deciphering Mg‐Surface Interactions with Unsaturated Hydrocarbons: An Integrated Experimental‐Theoretical Study
Authors: Ghoshal Sourav , Carnegie Nathaniel , Ezeakunne Chidozie , Dangi Beni B. , Kattel Shyam 
Published: January 2025

AbstractHere, we used a combination of laser‐induced experiments and density functional theory (DFT) calculations to study the mechanism of growth of carbonaceous species on the Mg surface. Experimental observations revealed that the carbon deposit forms upon laser illumination on the Mg surface, with the deposit being clearer and better structured in the presence of 1,3‐butadiene (C4H6) compared to ethylene (C2H4) gas. DFT thermodynamic and kinetic calculations of C2−C4 hydrocarbons interaction on low‐index Mg(0001) were used to explain this experimental observation. Our results on Mg(0001) showed that the cis isomer of C4H6 binds more strongly than its trans isomer via a [4+2] cycloaddition mechanism. We also investigated the adsorption of two units of C2H4 and C4H6 molecules, as well as the subsequent dehydrogenation stages that produce radical species responsible for chain growth mechanisms. The results showed that free energy change of dehydrogenation of two units of cis‐C4H6 [i. e. cis‐C8H12] is lower than the dehydrogenation of trans conformer of C4H6 and C2H4 molecule, indicating that the dehydrogenation of two units of cis‐C4H6 facilitates the initiation of growth of carbonaceous species on Mg surfaces. Therefore, the DFT calculations pinpoint the origin of the experimental observation of clearer carbon deposits on the Mg surface.
What Drives Consumer Willingness to Pay for Environmental, Social, and Governance Initiatives? A Choice Experiment
Authors: Lyu Seong Ok , Kim Changwook 
Published: January 2025

ABSTRACTThis study explores consumer preferences for Environmental, Social, and Governance (ESG) initiatives, utilizing a choice experiment within the context of sports organizations. This research aims to identify how each ESG dimension influences consumer decision‐making and the economic implications for organizations implementing these practices. By examining gender differences in preferences for ESG practices, this study provides nuanced insights into consumer attitudes toward diverse sustainability initiatives. Results indicate consumer willingness to pay for improved ESG practices, with distinctive variations across demographic segments. These findings suggest that consumers prioritize sustainability and ethical considerations in their choices, offering valuable implications for sports organizations seeking to enhance their ESG performance. This study contributes to the expanding body of literature on consumer behavior toward ESG, highlighting the economic benefits of aligning corporate strategies with consumer values. Our research underscores the importance of ESG initiatives in driving consumer engagement and promoting sustainable business practices.
Serum biomarkers as prognostic markers for Alzheimer's disease in a clinical setting
Authors: De Meyer Steffi , Blujdea Elena R. , Schaeverbeke Jolien M. , Adamczuk Katarzyna , Vandenberghe Rik , Poesen Koen , Teunissen Charlotte E. 
Published: January 2025

AbstractINTRODUCTIONBlood‐based glial fibrillary acidic protein (GFAP), neurofilament light chain (NfL), and phosphorylated tau (pTau) have shown promising prognostic potential in Alzheimer's disease (AD), but their applicability in clinical settings where comorbidities are prevalent remains uncertain.METHODSSimoa assays quantified GFAP, NfL, and pTau181 in retrospectively retrieved prediagnostic serum samples from 102 AD patients and 21 non‐AD controls.RESULTSHigher serum GFAP levels predicted earlier clinical presentation and faster subsequent Mini‐Mental State Examination decline in AD patients. Serum NfL levels were increased in patients with arterial hypertension (AHT), kidney dysfunction, and a history of stroke and only demonstrated predictive value for time to clinical AD presentation after adjustment for these comorbidities. Serum pTau181 instability during long‐term storage at −20°C prevented its prognostic evaluation in retrospectively retrieved serum samples.DISCUSSIONSerum GFAP is a robust prognostic marker for AD progression, whereas NfL is impacted by various comorbidities, which complicates the interpretation of its prognostic value.Highlights
Serum GFAP levels predict time to clinical AD presentation.
Serum NfL levels are increased by hypertension, kidney disease, and stroke history.
Prognostic value of serum NfL in AD is only evident after comorbidity correction.
Serum levels of GFAP, but not NfL, increase over time within prediagnostic AD stages.
Clinical and neuropathological associations of plasma Aβ42/Aβ40, p‐tau217 and neurofilament light in sporadic frontotemporal dementia spectrum disorders
Authors: Rajbanshi Binita , Prufer Q C Araujo Igor , VandeVrede Lawren , Ljubenkov Peter A. , Staffaroni Adam M. , Heuer Hilary W. , Lario Lago Argentina , Ramos Eliana Marisa , Petrucelli Leonard , Gendron Tania , Dage Jeffrey L. , Seeley William W. , Grinberg Lea T. , Spina Salvatore , Bateman Randall J. , Rosen Howard J. , Boeve Bradley F. , Boxer Adam L. , Rojas Julio C. ,   for the ALLFTD Consortium
Published: January 2025

AbstractINTRODUCTIONPlasma amyloid beta42/amyloid beta40 (Aβ42/Aβ40) and phosphorylated tau217 (p‐tau217) identify individuals with primary Alzheimer's disease (AD). They may detect AD co‐pathology in the setting of other primary neurodegenerative diseases, but this has not been systematically studied.METHODSWe compared the clinical, neuroimaging, and neuropathological associations of plasma Aβ42/Aβ40 (mass spectrometry), p‐tau217 (electrochemiluminescence), and neurofilament light ([NfL], single molecule array [Simoa]), as markers of AD co‐pathology, in a sporadic frontotemporal dementia (FTD) cohort (n = 620).RESULTSAβ42/Aβ40 showed no clinicopathological associations. High p‐tau217 was present in amnestic dementia (AmD) presumed to be due to FTD, logopenic primary progressive aphasia (lvPPA), and APOEε4 carriers, and correlated with worse baseline and longitudinal clinical scores, lower hippocampal volumes, and more severe AD co‐pathology (Braak Stage). NfL was elevated in all FTD phenotypes, and correlated with clinical scores and frontotemporal brain volumes.DISCUSSIONPlasma p‐tau217 has clinical, neuroimaging, and neuropathological correlates in sporadic FTD and may identify FTD cases with AD co‐pathology.Highlights
Alzheimer's disease (AD) features could be identified with plasma phosphorylated tau217 (p‐tau217) in frontotemporal lobar degeneration (FTLD).
Plasma p‐tau217 is a better discriminator of AD co‐pathology and AD‐associated features in FTLD than plasma amyloid beta42/amyloid beta40 (Aβ42/Aβ40) and neurofilament light (NfL).
In FTLD, plasma p‐tau217, but not Aβ42/Aβ40 or neurofilament light, has phenotypical, neurocognitive, and neuroimaging correlates suggestive of AD co‐pathology.
Combination of Two‐Stage Continuous Feeding and Optimized Synthetic Medium Increases Lipid Production in Lipomyces starkeyi
Authors: Wu Chih‐Chan , Okano Kenji , Religia Pijar , Soma Yuki , Takahashi Masatomo , Izumi Yoshihiro , Bamba Takeshi , Honda Kohsuke 
Published: January 2025

ABSTRACTThe oleaginous yeast Lipomyces starkeyi is recognized for its remarkable lipid accumulation under nitrogen‐limited conditions. However, precise control of microbial lipid production in L. starkeyi remains challenging due to the complexity of nutrient media.We developed a two‐stage fed‐batch fermentation process using a well‐defined synthetic medium in a 5‐L bioreactor. In the first stage, the specific growth rate was maintained at a designated level by maximizing the cell density through optimizing the feeding rate, molar carbon‐to‐nitrogen (C/N) ratio, and phosphate concentration in feeding media, achieving a high cell density of 213 ± 10 × 107 cells mL−1. In the second stage, we optimized the molar C/N ratio in the feeding medium for lipid production and achieved high biomass (130 ± 5 g L−1), lipid titer (88 ± 6 g L−1), and lipid content (67% ± 2% of dry cellular weight). Our approach yielded a high lipid titer, comparable to the highest reported value of 68 g L−1 achieved in a nutrient medium, by optimizing cultivation conditions with a synthetic medium in L. starkeyi. This highlights the importance of well‐established yet powerful bioprocess approaches for the precise control of microbial cultivation.
Impact of Diverse Parameters on CO2 Adsorption in CO2 Sequestration: Utilizing a Novel Triaxial Testing Apparatus
Authors: Ansari Ardehjani Emad , Ataei Mohammad , Sereshki Farhang , Mirzaghorbanali Ali , Aziz Naj 
Published: January 2025

ABSTRACTIn order to minimize greenhouse gas emissions, it is essential from an environmental point of view to employ CO2 sequestration technology to store CO2 in underground coal layers. To study this strategy, a triaxial testing apparatus is required. This study introduces a novel triaxial testing apparatus developed to explore enhanced coal bed methane (ECBM) and carbon dioxide (CO2) sequestration techniques. Several laboratory tests were conducted to validate the apparatus and study the behavior of coal exposed to CO2 using this machine. In fact, the implementation of this machine marks the initial step in an empirical feasibility analysis of CO2 sequestration in Iranian coal seams. This analysis involves examining the impact of ash content, ambient temperature, and saturation direction on CO2 adsorption and emission in various coal samples. Two different thermal coal samples from Chamestan and Tash mines were utilized. Some results, such as the trend of the coal sample's strain, show good correlation with previous work. Additionally, some results presented in this work are novel. On the basis of the results, the developed apparatus demonstrated satisfactory performance, and its innovative design fully meets the desired outcome. Higher ash content increases coal strength and reduces deformation. Lower ash content leads to more gas adsorption and deformation post‐saturation. Gas adsorption is higher at 25°C than at 4°C. Moreover, coal samples at 25°C had 12.5 times more axial strain than those at 4°C. Lateral saturation causes 13.72% larger axial strain changes than top and end saturation due to increased gas‐sample contact and penetration into the coal matrix.
Comprehensive Study and Evaluation of Significant Landslides Applying Geospatial and InSAR Coherence Techniques in Garhwal Himalaya, India
Authors: Saha Soumik , Bera Biswajit 
Published: January 2025

ABSTRACTLandslides are the common geo‐environmental hazard in Himalayan terrain. In the Indian Himalayan terrain, landslide‐related hazards have intensified in the past few decades as a result of human intervention in the geomorphological and geological equilibrium conditions. This paper investigates the occurrences and their associated factors (geomorphological, geological, human‐related factors) and presents a complete geomorphological mapping of four selected landslides, i.e., landslide near the Budhakedar region (landslide‐1/L1), landslide near the Saund region (landslide‐2/L2), Sirobagad landslide zone (landslide‐3/L3) and Rampur landslide near Sonprayag (landslide‐4/L4). These slides are mainly reactivated landslides, which become active during the monsoon period. Rock strength analysis (using rebound values from a standard N‐type Schmidt hammer) shows that the rebound value is around 30 in most of the cases, but in the case of landslide 2, the intact rocks have a rebound value near about 60–65. Landslides 1, 3 and 4 are rock‐cum‐debris slides dominated by gneiss‐schist, phyllite and quartzite types of rock, respectively, and landslide 2 is mainly a rock slide. The grain size test shows that the soil is poorly graded, which is composed of gravel and sand in every case. In the case of slide 2 (rockslide), the soil is classified as gravelly soil. The landslide activeness has been detected based on interferometric coherence change detection analysis using single look complex (SLC) sentinel 1A imageries (pre‐monsoon and post‐monsoon). The coherence results enable us to detect surface deformation over time. The result based on the InSAR coherence technique also stipulated the surface deformation or reactivation of the slides after the effect of rainfall.
The Perceived Concerns of Nurse Educators' Use of GenAI in Nursing Education: Protocol for a Scoping Review
Authors: Gehring Denise R. , Titus Sharon K. , George Ragi 
Published: January 2025

ABSTRACTBackground/AimsSince the emergence of generative AI (GenAI) in fall 2022, its impact on higher education has been significant yet under‐researched, leading to mixed reactions among nurse educators, ranging from enthusiasm to skepticism. A preliminary search of seven databases found no scoping reviews specifically that addressed nurse educators' concerns about using GenAI. Therefore, this study aims to map the existing literature on nurse educators' concerns regarding the use of GenAI in nurse education.Inclusion CriteriaIncluded are any types of sources (peer‐reviewed and nonpeer‐reviewed) in English and from any country and were authored by an academic nurse educator that reported on “academic nurse educators,” and “artificial intelligence” (such as GenAI, Generative AI, ChatGPT, large language models) in nursing education. Articles that did not report “nurse educator concerns,” or were focused on clinical practice were excluded.MethodsThis protocol (see PRISMA‐P in Appendix 1) establishes the study parameters for the planned scoping review, which will be conducted from April to July 2024. We will follow Joanna Briggs Institute, a comprehensive methodology, to ensure a rigorous approach. The final review will include relevant literature from eight academic databases published from Fall 2022 through April 2024. Data will be reported using the PRISMA‐ScR checklist and flow diagram (2020) along with other visual diagrams to add validity to our findings. An inductive analysis approach will be used to code the evolving data, identify recurring themes, and pinpoint potential gaps in the literature.ResultsThe final scoping review will present the search results, the study inclusion process, and the data analysis.ConclusionOur planned review will potentially provide crucial insights into nurse educators' concerns on using GenAI, pinpointing gaps within the literature, and providing direction for future research.Review RegistrationThis protocol was registered on May 8, 2024, on Open Science Framework (OSF). The registry number is OSF.IO/SZ8WR. This registration ensures the transparency and credibility of our research process, as it provides a public record of our study design and methods.
Novel Silk Fibroin Based Bilayer Scaffolds for Bioabsorbable Internal Biliary Stenting
Authors: Isella Benedetta , Hassan Nourhan , Drinic Aleksander , Eickhoff Roman M. , Kröger Nadja , Vaughan Ted J. , Kopp Alexander 
Published: January 2025

ABSTRACTBiliary duct reconstruction is one of the most challenging parts of liver transplantation and accounts for 40%–60% of complications. While current stent‐based devices on the market show promising results in reducing complications, they are manufactured from permanent synthetic materials and require a second reintervention for their removal. This exposes the patients to other potential complications and increases healthcare costs. This study develops a fabrication technique to produce a bioabsorbable biliary stent based on silk fibroin. The process used a dip‐coating procedure for silk fibroin that produced highly smooth monolayer tubular specimens without the use of any additional surfactants during removal. This process was combined with an electrospinning step to produce bilayer structures through the deposition of electrospun silk fibroin on the outer surface. The structures proved to have promising mechanical, morphological, and cytocompatibility properties for use in the field of biliary stenting. Furthermore, the technique investigated proved to be reproducible, achieving an important requirement for large‐scale use even in the presence of a biomaterial derived from a natural source. These results show the possibility of obtaining a completely bioabsorbable internal biliary stent that does not require any second reintervention. This study can be the starting point for further investigations both in vitro and in vivo to assess the suitability of silk fibroin biliary stents for clinical applications.
Simvastatin‐Loaded Chitosan Microspheres as a Biomaterial for Dentin Tissue Engineering
Authors: Bronze‐Uhle Erika Soares , Melo Camila Correa da Silva Braga de , da Silva Isabela Sanches Pompeo , Stuani Vitor de Toledo , Bueno Victor Hugo , Rinaldo Daniel , de Souza Costa Carlos Alberto , Lisboa Filho Paulo Noronha , Soares Diana Gabriela 
Published: January 2025

ABSTRACTIn the present study, chitosan microspheres (MSCH) loaded with different concentrations of simvastatin (2%, 5%, and 10%) were synthesized as a biomaterial for dentin tissue engineering. The microspheres were prepared by emulsion crosslinking method, and simvastatin was incorporated during the process. The microspheres were then physicochemically and morphologically characterized. Scanning electron microscopy and infrared spectroscopy confirmed the spherical morphology of synthesized microspheres and the chemical incorporation of simvastatin into MSCH, respectively. UV–visible absorption confirmed the controlled and continuous release pattern of the drug. To mimic the clinical application in vitro, the microspheres were applied onto three‐dimensional (3D) cultures of human dental pulp cells (HDPCs). Cell viability, proliferation, and in situ‐mineralized matrix deposition were evaluated. The results indicated no cytotoxic effects for all 3D cultures for all tested biomaterials, with cells being able to proliferate significantly over time. HDPCs showed a significant increase in the deposition of mineralization nodules when 3D cultures were in direct contact with chitosan microspheres in comparison to control; nevertheless, the highest expression was observed for MSCH encapsulated with 5% and 10% simvastatin, which was significantly higher than plain MSCH. Therefore, chitosan microsphere systems loaded with 5%–10% simvastatin provided the development of a controlled release system in bioactive dosages for dentin tissue engineering.
Rho GTPase Signaling: A Molecular Switchboard for Regulating the Actin Cytoskeleton in Axon Guidance
Authors: Gorla Madhavi , Guleria Digvijay Singh 
Published: January 2025

ABSTRACTAxon pathfinding is a highly dynamic process regulated by the interactions between cell‐surface guidance receptors and guidance cues present in the extracellular environment. During development, precise axon pathfinding is crucial for the formation of functional neural circuits. The spatiotemporal expression of axon guidance receptors helps the navigating axon make correct decisions in a complex environment comprising both attractive and repulsive guidance cues. Axon guidance receptors initiate distinct signaling cascades that eventually influence the cytoskeleton at the growing tip of an axon, called the growth cone. The actin cytoskeleton is the primary target of these guidance signals and plays a key role in growth cone motility, exploration, and behavior. Of the many regulatory molecules that modulate the actin cytoskeleton in response to distinct guidance signals, Rho GTPases play central roles. Rho GTPases are molecular switchboards; their ON (GTP‐bound) and OFF (GDP‐bound) switches are controlled by their interactions with proteins that regulate the exchange of GDP for GTP or with the proteins that promote GTP hydrolysis. Various upstream signals, including axon guidance signals, regulate the activity of these Rho GTPase switch regulators. As cycling molecular switches, Rho GTPases interact with and control the activities of downstream effectors, which directly influence actin reorganization in a context‐dependent manner. A deeper exploration of the spatiotemporal dynamics of Rho GTPase signaling and the molecular basis of their involvement in regulating growth cone actin cytoskeleton can unlock promising therapeutic strategies for neurodevelopmental disorders linked to dysregulated Rho GTPase signaling. This review not only provides a comprehensive overview of the field but also highlights recent discoveries that have considerably advanced our understanding of the complex regulatory roles of Rho GTPases in modulating actin cytoskeleton arrangement at the growth cone during axon guidance.