bluuebunny/crossref_metadata_2025_split huggingface dataset:
The impact of maternal and paternal birth weights on infant birth weights: the Japan environment and children’s study
Authors: Tomita Hasumi , Iwama Noriyuki , Hamada Hirotaka , Kudo Rie , Tagami Kazuma , Kumagai Natsumi , Sato Naoto , Izumi Seiya , Sakurai Kasumi , Watanabe Zen , Ishikuro Mami , Obara Taku , Tatsuta Nozomi , Hoshiai Tetsuro , Metoki Hirohito , Saito Masatoshi , Sugawara Junichi , Kuriyama Shinichi , Arima Takahiro , Yaegashi Nobuo ,   The Japan Environment and Children’s Study Group
Published: January 2024

AbstractThis study aimed to evaluate the association between parental and infant birth weights in Japan. In total, 37,504 pregnant Japanese women and their partners were included in this birth cohort study. A multinomial logistic regression model was used to evaluate the associations of parental birth weights with small-for-gestational-age (SGA) or large-for-gestational-age (LGA) infants. Associations between parental birth weight and low birth weight (LBW) infants or macrosomia were also examined, and linear associations between parental birth weight and SGA or LGA were found. The adjusted odds ratios (aORs) for SGA infants per 500 g decrease in maternal and paternal birth weights were 1.50 (95% confidence interval [CI],1.43–1.58) and 1.31 (95% CI, 1.25–1.38), respectively. The aORs for LGA infants per 500 g increase in maternal and paternal birth weights were 1.53 (95% CI, 1.47–1.60) and 1.41 (95% CI, 1.35–1.47), respectively. The association between parental birth weight and LBW infants or macrosomia was also linear. The aORs for LBW infants per 500 g decrease in maternal and paternal birth weights were 1.47 (95% CI, 1.40–1.55) and 1.25 (95% CI, 1.19–1.31), respectively. The aORs for macrosomia per 500 g increase in maternal and paternal birth weights were 1.59 (95% CI, 1.41–1.79) and 1.40 (95% CI, 1.23–1.60), respectively. Parental birth weight was found to be associated with infant birth weight even after adjusting for various parental factors. Furthermore, maternal birth weight was more strongly associated with infant birth weight than with paternal birth weight.
Millennial‐Scale Changes in Atmospheric Nitrous Oxide During the Holocene
Authors: Azharuddin Syed , Ahn Jinho , Ryu Yeongjun , Brook Ed , Salehnia Nasrin 
Published: January 2024

AbstractNitrous oxide (N2O) is an important greenhouse gas which destroys the ozone in the stratosphere. Primary sources of atmospheric N2O are nitrification and denitrification in terrestrial soils and the ocean, and the main sink is photolysis in the stratosphere. Studies have mostly focused on the climate‐related response of N2O during glacial‐interglacial periods. However, its mechanism of variation during the Holocene remains unclear. We present a high‐resolution N2O record from the South Pole Ice (SPICE) core covering the Holocene epoch. The millennial‐scale N2O trend agrees with existing records. We constructed a Holocene composite consisting of the new N2O measurements in SPICE and existing records from other ice core sites. The N2O composite reveals four distinct periods of N2O variation during 11.5–10.0 ka, 10.0–6.2 ka, 6.2–2.2 ka, and 2.2–1.4 ka, including two maxima in 11.0–10.0 ka and 3.0–2.2 ka and minima in 8.8–6.2 ka and approximately 1.4 ka. Apart from these, our new high‐resolution record from SPICE shows a short‐term N2O decrease around 2.8 ka which is not observed in other records possibly due to lower sample resolution and/or higher age smoothing. Comparison of our new Holocene N2O composite with the paleo‐proxy records suggests the plausible linkage of major monsoon (Asian, North African, South and North American, and Australian‐Indonesian monsoon) and upwelling (Arabian Sea and Eastern Tropical South Pacific) regions in regulating the atmospheric N2O during the Holocene.
Mapping Daily Air Temperature Over the Hawaiian Islands From 1990 to 2021 via an Optimized Piecewise Linear Regression Technique
Authors: Kodama Keri M. , Kourkchi Ehsan , Longman Ryan J. , Lucas Matthew P. , Bateni Sayed M. , Huang Yu‐Fen , Kagawa‐Viviani Aurora , Mclean Jared , Cleveland Sean B. , Giambelluca Thomas W. 
Published: January 2024

AbstractGridded air temperature data are required in various fields such as ecological modeling, weather forecasting, and surface energy balance assessment. In this work, a piecewise multiple linear regression model is used to produce high‐resolution (250 m) daily maximum (Tmax), minimum (Tmin), and mean (Tmean) near‐surface air temperature maps for the State of Hawaiʻi for a 32‐year period (1990–2021). Multiple meteorological and geographical variables such as the elevation, daily rainfall, coastal distance index, leaf area index, albedo, topographic position index, and wind speed are independently tested to determine the most well‐suited predictor variables for optimal model performance. During the mapping process, input data scarcity is addressed first by gap‐filling critical stations at high elevation using a predetermined linear relationship with other strongly‐correlated stations, and second, by supplementing the training dataset with station data from neighboring islands. Despite the numerous covariates physically linked to temperature, the most parsimonious model selection uses elevation as its sole predictor, and the inclusion of the additional variables results in increased cross‐validation errors. The mean absolute error of resultant estimated Tmax and Tmin maps over the Hawaiian Islands from 1990 to 2021 is 1.7°C and 1.3°C, respectively. Corresponding bias values are 0.01°C and −0.13°C, respectively for the same variables. Overall, the results show the proposed methodology can robustly generate daily air temperature maps from point‐scale measurements over complex topography.
Evidence of Ice‐Rich Layered Deposits in the Medusae Fossae Formation of Mars
Authors: Watters Thomas R. , Campbell Bruce A. , Leuschen Carl J. , Morgan Gareth A. , Cicchetti Andrea , Orosei Roberto , Plaut Jeffrey J. 
Published: January 2024

AbstractSubsurface reflectors in radar sounder data from the Mars Advanced Radar for Subsurface and Ionospheric Sounding instrument aboard the Mars Express spacecraft indicate significant dielectric contrasts between layers in the Martian Medusae Fossae Formation (MFF). Large density changes that create dielectric contrasts are less likely in deposits of volcanic ash, eolian sediments, and dust, and compaction models show that homogeneous fine‐grained material cannot readily account for the inferred density and dielectric constant where the deposits are more than a kilometer thick. The presence of subsurface reflectors is consistent with a multi‐layer structure of an ice‐poor cap above an ice‐rich unit analogous to the Martian Polar Layered Deposits. The volume of an ice‐rich component across the entire MFF below a 300–600 m dry cover corresponds to a global equivalent layer of water of ∼1.5 to ∼2.7 m or ∼30%–50% of the total estimated in the North Polar cap.
Vegetation Index‐Based Models Without Meteorological Constraints Underestimate the Impact of Drought on Gross Primary Productivity
Authors: Chen Xin , Chen Tiexi , Liu Shuci , Chai Yuanfang , Guo Renjie , Dai Jie , Wang Shengzhen , Zhang Lele , Wei Xueqiong 
Published: January 2024

AbstractRecently developed solar‐induced chlorophyll fluorescence‐related vegetation indices (e.g., near infrared reflectance of vegetation (NIRv) and kernel normalized difference vegetation index (kNDVI)) have been reported to be appropriate proxies for vegetation photosynthesis. These vegetation indices can be used to estimate gross primary productivity (GPP) without considering meteorological constraints. However, it is not clear whether such a statement holds true under various environmental conditions. In this study, we explored whether these vegetation indices require meteorological constraints to better characterize GPP under extreme drought conditions using three extreme drought cases in Europe in 2003, 2010, and 2018. According to the long‐term series of observations, vegetation indices (NIRv and kNDVI) alone explained 60% and 57%, respectively, of the weekly GPP variation across the 66 flux sites. The explained variation increased to 69% and 64%, respectively, for the models that take into account radiative effects (NIRv and kNDVI multiplied by radiation). However, without considering meteorological constraints, these vegetation index‐based estimations severely underestimated negative GPP anomalies under drought stress, especially in models that incorporate radiative effects. After incorporating vapor pressure deficit (VPD)‐based meteorological constraints, the GPP estimations exhibited more pronounced negative anomalies during drought periods while maintaining model accuracy (at 70% and 65%, respectively). In addition, the GPP models based on site observations were applied at the regional scale (Europe). Our results indicated that the models without meteorological constraints again underestimated the impact of drought on GPP. This study emphasizes the importance of meteorological constraints in the estimation of GPP, especially under extreme drought conditions.
Long‐Term Variation of the Galactic Cosmic Ray Radiation Dose Rates
Authors: Lyu D. , Qin G. , Shen Z.‐N. 
Published: January 2024

AbstractIn this work, a model for calculating the galactic cosmic rays (GCRs) radiation dose rate is developed. The model is based on a GCR modulation model, which is established by Shen and Qin, and the fluence‐dose conversion coefficients (FDCCs) published by the International Commission on Radiological Protection (ICRP). With the model, the radiation absorbed dose rate of GCRs near the lunar surface over long time periods is calculated and compared with the observation data from the Cosmic Ray Telescope for the Effects of Radiation and the Lunar Lander Neutron and Dosimetry. First, the energy spectrum of GCRs at 1 AU in the ecliptic, where the lunar orbit is located, is computed using the GCR modulation model. Then, using the FDCCs of ICRP 123, the absorbed dose rates of 15 human organs/tissues at the lunar orbit position are calculated to represent the general absorbed dose rate of the body (in water). Furthermore, considering the albedo radiation (excluding neutrons) and using the water‐silicon conversion coefficients, the total absorbed dose rates of GCRs near the lunar surface (in silicon) are calculated, it is shown that our modeling results generally agree with the observations from spacecraft. This work is useful for future manned space exploration to the Moon or other celestial bodies in the solar system.
The Overall Collection Efficiency of Catching‐Type Precipitation Gauges in Windy Conditions
Authors: Cauteruccio A. , Chinchella E. , Lanza L. G. 
Published: January 2024

AbstractThe wind‐induced bias of catching‐type precipitation measurement instruments is quantified using Computational Fluid Dynamics with embedded liquid (raindrops) and solid (snowflakes) particle tracking. The performance of six common commercial gauges having different outer geometry is compared under a range of Precipitation Intensity (PI) and wind speed conditions by means of the numerically calculated catch ratios. Validation of the simulated aerodynamic behavior and its effect on water drop trajectories is provided by previous wind tunnel experiments. The functional dependence of the overall collection efficiency on the PI is derived as a quantitative measure of the instrument performance under a wind climatology with a uniform probability density function. Instruments with aerodynamic design produce a less pronounced diversion of hydrometeor trajectories—at any given size—than those having more traditional geometry. For liquid precipitation measurements, chimney‐shaped instruments rank low, while inverted conical and Nipher shielded instruments are quite performant solutions. The investigated quasi‐cylindrical gauges have intermediate behavior depending on their detailed aerodynamic features. For solid precipitation, all instruments rank low at light to moderate PI, except the Nipher shielded gauge. Results allow selecting the appropriate instrument for the local precipitation climatology at the measurement site and can be used to apply suitable adjustments to the measured precipitation.
Quantifying the Impact of Human Activities on Hydrological Drought and Drought Propagation in China Using the PCR‐GLOBWB v2.0 Model
Authors: Yang Xiaoli , Wu Fan , Yuan Shanshui , Ren Liliang , Sheffield Justin , Fang Xiuqin , Jiang Shanhu , Liu Yi 
Published: January 2024

AbstractThe economic and human losses caused by drought are increasing, driven by climate change, human activities, and increased exposure of livelihood activities in water‐dependent sectors. Mitigation of these impacts for socio‐ecological securit is necessary to gain a better understanding of how human activities contribute to the propagation of drought as water management further develops. The previous studies investigated the impact of human activities on a macro level, but they overlooked the specific effects caused by human water management measures. In addition, most studies focus on the propagation time (PT, the number of months from meteorological drought propagation to hydrological drought), while other drought propagation characteristics, such as duration, magnitude, and recovery time, are not yet sufficiently understood. To tackle these issues, the PCR‐GLOBWB v2.0 hydrological model simulated hydrological processes in China under natural and human‐influenced scenarios. The study assessed how human activities impact hydrological drought and its propagation. Result shows that human activities have exacerbated hydrological drought in northern China, while it is mitigated in the south. The propagation rate (PR, proportion of meteorological drought propagation to hydrological drought) ranges from 45% to 75%, and the PT is 6–23 months. The PR does not differ substantially between the north and south, while the PT is longer in the north. The PR decreases by 1%–60% due to human activities, and the PT decreases (1–13 months) in the north and increases (1–10 months) in the south. Human activities display significant variations in how they influence the propagation process of drought across different basins. The primary factors driving the spatial pattern of drought disparities are regional variations in irrigation methods and the storage capacity of reservoirs.
A flexible, thin-film microchannel electrode array device for selective subdiaphragmatic vagus nerve recording
Authors: Lim Jongcheon , Zoss Peter A. , Powley Terry L. , Lee Hyowon , Ward Matthew P. 
Published: January 2024

AbstractThe vagus nerve (VN) plays an important role in regulating physiological conditions in the gastrointestinal (GI) tract by communicating via the parasympathetic pathway to the enteric nervous system (ENS). However, the lack of knowledge in the neurophysiology of the VN and GI tract limits the development of advanced treatments for autonomic dysfunctions related to the VN. To better understand the complicated underlying mechanisms of the VN-GI tract neurophysiology, it is necessary to use an advanced device enabled by microfabrication technologies. Among several candidates including intraneural probe array and extraneural cuff electrodes, microchannel electrode array devices can be used to interface with smaller numbers of nerve fibers by securing them in the separate channel structures. Previous microchannel electrode array devices to interface teased nerve structures are relatively bulky with thickness around 200 µm. The thick design can potentially harm the delicate tissue structures, including the nerve itself. In this paper, we present a flexible thin film based microchannel electrode array device (thickness: 11.5 µm) that can interface with one of the subdiaphragmatic nerve branches of the VN in a rat. We demonstrated recording evoked compound action potentials (ECAP) from a transected nerve ending that has multiple nerve fibers. Moreover, our analysis confirmed that the signals are from C-fibers that are critical in regulating autonomic neurophysiology in the GI tract.
The m6A demethylases FTO and ALKBH5 aggravate the malignant progression of nasopharyngeal carcinoma by coregulating ARHGAP35
Authors: Yang Zhiyuan , Zhang Siyu , Xiong Jiayan , Xia Tian , Zhu Rui , Miao Mengyu , Li Keying , Chen Wenyue , Zhang Lin , You Yiwen , You Bo 
Published: January 2024

AbstractN6-methyladenosine (m6A) is an RNA modification that can be removed by demethylases [fat mass and obesity-associated protein (FTO) and AlkB homolog 5 (ALKBH5)], which regulate gene expression and cell function. We show that m6A levels and m6A demethylase levels are altered in nasopharyngeal carcinoma (NPC) tissues vs. normal tissues. High FTO and ALKBH5 predict a poor prognosis in NPC patients. Silencing FTO and ALKBH5 inhibited the malignant behavior of patient-derived NPC cells in a short time. However, as time progressed, the inhibitory effect of FTO or ALKBH5 was weakened, and the cosilencing of FTO and ALKBH5 maintained a better inhibitory effect. Combined transcriptome and m6A-seq analysis revealed a downstream target gene that was jointly regulated by FTO and ALKBH5 in NPC, and ARHGAP35 was chosen to do further study. The synergistic silencing of FTO and ALKBH5 increased the methylation level on the mRNA CDS of a new transcription factor (ARHGAP35) and positively regulate the protein coding capacity and mRNA stability of ARHGAP35, thus leading to increased expression of ARHGAP35 and inhibition of the malignant phenotype of tumor cells. Our study revealed that the growth and metastasis of NPC can be stably inhibited through synergistic silencing of the demethylases FTO and ALKBH5, which play a positive role in the treatment of NPC by regulating the downstream transcript ARHGAP35 and increasing its m6A level.
Diagnostic outcome of pro bono neurogenetic diagnostic service in Sri Lanka: A wealth creation
Authors: Gonawala Lakmal , Wijekoon Nalaka , Attanayake Darshika , Ratnayake Pyara , Sirisena Darshana , Gunasekara Harsha , Dissanayake Athula , Keshavaraj Ajantha , Mohan Chandra , Steinbusch Harry W. M. , Hoffman Eric P. , Dalal Ashwin , de Silva K. Ranil D. 
Published: January 2024

AbstractThe inherited disease community in Sri Lanka has been widely neglected. This article aimed to present accumulated knowledge in establishing a pro bono cost-effective national, island-wide, free-of-charge molecular diagnostic service, suggesting a model for other developing countries. The project provided 637 molecular diagnostic tests and reports free of charge to a nation with limited resources. We pioneered the implementation of mobile clinics and home visits, where the research team acted as barefoot doctors with the concept of the doctor and the researcher at the patient’s doorstep. Establishing pro bono, cost-effective molecular diagnostics is feasible in developing countries with limited resources and state funding through the effort of dedicated postgraduate students. This service could provide an accurate molecular diagnosis of Duchenne muscular dystrophy, Huntington’s disease, Spinocerebellar ataxia, and Spinal muscular atrophy, a diagnostic yield of 54% (343/637), of which 43% (147/343) of the patients identified as amenable for available gene therapies. Initiated human resource development by double doctoral degree opportunities with international collaborations. Established a neurobiobank and a national registry in Sri Lanka, a rich and unique repository, wealth creation for translational collaborative research and sharing of information in neurological diseases, as well as a lodestar for aspiring initiatives from other developing countries.
A recurrent synonymous L1CAM variant in a fetus with hydrocephalus
Authors: Šubrt Ivan , Zavoral Tomáš , Strych Lukáš , Černá Monika , Hejnalová Markéta , Komrsková Pavla , Tejcová Jitka 
Published: January 2024

Abstract
We report the case of a hydrocephalic fetus in which clinical exome sequencing revealed a recurrent synonymous variant of unknown significance, c.453G>T, in the L1CAM gene. This report presents the second case of X-linked hydrocephalus in a fetus with this variant. Since we reproduced the RNA analysis, we were able to reclassify this variant as likely pathogenic. Our results stress the importance of not excluding synonymous variants during prioritization.
Ultraconserved bacteriophage genome sequence identified in 1300-year-old human palaeofaeces
Authors: Rozwalak Piotr , Barylski Jakub , Wijesekara Yasas , Dutilh Bas E. , Zielezinski Andrzej 
Published: January 2024

AbstractBacteriophages are widely recognised as rapidly evolving biological entities. However, knowledge about ancient bacteriophages is limited. Here, we analyse DNA sequence datasets previously generated from ancient palaeofaeces and human gut-content samples, and identify an ancient phage genome nearly identical to present-day Mushuvirus mushu, a virus that infects gut commensal bacteria. The DNA damage patterns of the genome are consistent with its ancient origin and, despite 1300 years of evolution, the ancient Mushuvirus genome shares 97.7% nucleotide identity with its modern counterpart, indicating a long-term relationship between the prophage and its host. In addition, we reconstruct and authenticate 297 other phage genomes from the last 5300 years, including those belonging to unknown families. Our findings demonstrate the feasibility of reconstructing ancient phage genome sequences, thus expanding the known virosphere and offering insights into phage-bacteria interactions spanning several millennia.
Latent representations in hippocampal network model co-evolve with behavioral exploration of task structure
Authors: Cone Ian , Clopath Claudia 
Published: January 2024

AbstractTo successfully learn real-life behavioral tasks, animals must pair actions or decisions to the task’s complex structure, which can depend on abstract combinations of sensory stimuli and internal logic. The hippocampus is known to develop representations of this complex structure, forming a so-called “cognitive map”. However, the precise biophysical mechanisms driving the emergence of task-relevant maps at the population level remain unclear. We propose a model in which plateau-based learning at the single cell level, combined with reinforcement learning in an agent, leads to latent representational structures codependently evolving with behavior in a task-specific manner. In agreement with recent experimental data, we show that the model successfully develops latent structures essential for task-solving (cue-dependent “splitters”) while excluding irrelevant ones. Finally, our model makes testable predictions concerning the co-dependent interactions between split representations and split behavioral policy during their evolution.
A review of the pathophysiological mechanisms of doxorubicin-induced cardiotoxicity and aging
Authors: Linders Annet Nicole , Dias Itamar Braga , López Fernández Teresa , Tocchetti Carlo Gabriele , Bomer Nils , Van der Meer Peter 
Published: January 2024

AbstractThe population of cancer survivors is rapidly increasing due to improving healthcare. However, cancer therapies often have long-term side effects. One example is cancer therapy-related cardiac dysfunction (CTRCD) caused by doxorubicin: up to 9% of the cancer patients treated with this drug develop heart failure at a later stage. In recent years, doxorubicin-induced cardiotoxicity has been associated with an accelerated aging phenotype and cellular senescence in the heart. In this review we explain the evidence of an accelerated aging phenotype in the doxorubicin-treated heart by comparing it to healthy aged hearts, and shed light on treatment strategies that are proposed in pre-clinical settings. We will discuss the accelerated aging phenotype and the impact it could have in the clinic and future research.