bluuebunny/crossref_metadata_2025_split huggingface dataset:
Protective association between human papilloma virus and handgrip strength in women, a cross-sectional study
Authors: Li Xiang , Ma Jinlong , Sun Zhenqian , Chen Yunzhen , Jiao Guangjun 
Published: January 2024

Abstract
Background
To understand the relationship between human papilloma virus (HPV) and handgrip strength (HS) in women.
Methods
We based our survey on data from the National Health and Nutrition Examination Survey (2011–2014). Comparable dataset was created by propensity score matching (1: 1). The Welch two-sample t test was used to analyze the association between HPV infection and HS. For further validation, a linear mixed model was performed. Restricted cubic spline curve and Kendall's tau-b test were used to explore the effect of HPV infection type on HS.
Results
A total of 1118 female eligible subjects were included in the comparable dataset. The mean HS of 559 subjects infected with HPV was 60.83 ± 9.65 (Kg), which was significantly higher than that of uninfected subjects (59.16 ± 10.89) (P = 0.007). Linear mixed model revealed a higher HS (mean increase = 1.094) was found in subjects infected with HPV (P = 0.026), compared to uninfected. And the larger the number of cooccurring HPV types in a woman, the higher the HS was (P for nonlinear < 0.05). In addition, Kendall's tau-b correlation tests showed HPV type 59 was negatively correlated with HS. HPV type 51, 61 and 72 were positively correlated with HS.
Conclusions
There is a protective association between HPV infection and HS in female subjects by analyzing data from a nationally representative database. The larger the number of cooccurring HPV types, the higher the HS was.
Comparison Of noninvasiv Indexes in the Determination of NAFLD in Obese Adolescents And A Recommendation For A Diagnostic Chart
Authors: Yetim Aylin , Şahin Memduh , Kandemir İbrahim , Bulakçı Betül , Aksakal Melike Tuğrul , Karapınar Edanur , Sever Hayrettin , bas firdevs 
Published: January 2024

Abstract
Introduction: Non-alcoholic fatty liver disease (NAFLD) is an increasingly common health issue in obese children and adolescents. NAFLD does not occur in every obese patient and in some cases, ultrasonography is inadequate for diagnosis.In this study, BMI SDS, WC SDS, triponderal mass index (TPMI), HbA1c, HOMA-IR, TG/HDL, LAP index, triglyceride-glucose (TyG) index and aminotransferase index, used in the diagnosis of NAFLD in obese adolescents,were examined together and their diagnostic values for clinical use were compared. Material and method: Adolescents who presented at a pediatric clinic between January and August 2022 and who had been diagnosed with exogenous obesity without any comorbidities,were included in the study.The presence of NAFLD was assessed using liver MRI. Laboratory findings were obtained retrospectively from the system records. Gender, HOMA-IR, TyG index and aminotransferase index were evaluated using logistic regression analysis. Results: In the comparison between NAFLD(+) and NAFLD(-) obese adolescent groups, HbA1c, HOMA-IR, aminotransferase index and TyG index were higher in the NAFLD (+) group (p = 0.012;p = 0.001; p = 0.012; p = 0.002, respectively). There was a positive correlation between liver fat percentage and HOMA-IR,TyG index,aminotransferase index and TG/HDL. According to regression analysis, male gender and HOMA-IR elevation were determined to be significant risk factors for NAFLD). Conclusion: Even if no NAFLD is detected on USG imaging, evaluation of HOMA-IR and TyG index levels, especially in high-risk patients, will support the diagnosis of NAFLD. In obese adolescents with a HOMA-IR value of ≥ 4.55and a TyG index value of ≥ 8.38, evaluation should be made with liver MRI, even if no NAFLD is detected on USG imaging. A basic chart with ALT, HOMA-IR, TyG, and gender with a diagnostic accuracy of 80%, positive predictive value of82.5% and sensitivity of 80% may assist in diagnosis of NAFLD in obese adolescents.
Is EUS-Guided Hepaticogastrostomy Safe and Effective After Failed ERCP: A Comprehensive Systematic Review and Metanalysis
Authors: Alsakarneh Saqr , Madi Mahmoud Y , Kilani Yassine , Jaber Fouad , Ahmed Mohammad , Beran Azizullah , Abdallah Mohamed , Ta’ani Omar Al , Mittal Anika , Numan Laith , Bilal Mohammad , Kiwan Wissam 
Published: January 2024

Abstract
Introduction: EUS-HGS has recently emerged as an alternative option for biliary drainage in cases of failed endoscopic retrograde cholangiopancreatography (ERCP). There is limited and variable data on safety and efficacy of EUS-HGS in the literature. In this comprehensive metanalysis, we aim to study the safety and efficacy of EUS-HGS in cases of failed conventional ERCP.
Methods: Embase, PubMed, and Web of Science databases were searched to include all studies that evaluated the efficacy and safety of EUS-HGS. Using the random effect model, the pooled, weight-adjusted event rate estimate for the clinical outcomes in each group was calculated with 95% confidence intervals (CIs). The primary outcomes were technical and clinical success rate.
Results: Our analysis included 70 studies with a total of 3527 patients. The pooled technical and clinical success rate for EUS-HGS were 98.1% ([95% CI, 97.5–98.7]; I2 = 40%) and 98.1% ([95% CI, 97.5–98.7]; I2 = 40%), respectively. The pooled incidence rate of total adverse events with EUS-HGS was 14.9% (95% CI, 12.7–17.1) with bile leakage being the most common (2.4% [95% CI, 1.7–3.2]). The pooled incidence of recurrent biliary obstruction (RBO) was 15.8% [95% CI, 12.2–19.4] with a high success rate for reintervention (97.5% [95% CI, 94.7–100]).
Conclusion: Our analysis showed a high technical and clinical success rate of EUS-HGS making it as feasible and effective alternative to ERCP. The ongoing development of dedicated devices and techniques is expected to make EUS-HGS more accessible and safer for patients in need of biliary drainage.
On-chip resistive microfluidic flow sensor with reduced analysis time using transient analysis
Authors: Deswal Harsh , Kanaparthi Srinivasulu , Singh Shiv Govind , Agrawal Amit 
Published: January 2024

Abstract

In the realm of microfluidics, a critical issue prevails: the majority of flow sensors are situated external to the microfluidic chip itself, resulting in an inherent deficiency of precise operational insights. Fields like drug development, concentration gradient generation, and proactive healthcare demand meticulous, dependable data for broader utilization. In our current work, we introduce a microfluidic flow sensor designed to gauge electrochemical resistance within a circuit comprising electrolytic fluid and inter-digitated electrodes. This sensor's design features a Si wafer substrate housing micropatterned Ti/Pt electrode seamlessly bonded to a polydimethylsiloxane microchannel using oxygen plasma. What sets this innovation apart is the placement of microelectrodes within the microchannel, enabling on-chip flow rate measurements. Employing aqueous NaCl with variable solute concentrations ranging from 0.1 M to 0.4 M, we optimized the microchannel dimensions to accommodate flow rates spanning 0-500 µL/min. The sensor achieves a limit of detection (LOD) at 1 µL/min and boasts a resolution of 5 µL/min for lower flow rates (0 to 100 µL/min), while maintaining a resolution of 100 µL/min for higher flow rates (100 to 500 µL/min). Moreover, we have implemented an algorithm based on the trapezoidal rule, enabling flow rate prediction within 5 seconds. With its capability to swiftly and accurately measure flow rates across a wide spectrum, this proposed device emerges as an invaluable tool for applications mandating continuous flow rate monitoring.
Analysis of risk factors, clinical outcomes, and medical costs for pelvic infection after open pelvic fractures: A seven-year retrospective observation study at a single trauma centre
Authors: Choi Donghwan , So Jungsub , Cho Won Tae , Song Hyung Keun , Jung Kyoungwon 
Published: January 2024

Abstract
Background: Patients with unstable pelvic fractures usually die from haemorrhagic shock, whereas those with open pelvic fractures (OPF) die from pelvic infections (PIs) and pelvic sepsis (PS). We examined the clinical characteristics and results of PI in patients with OPFs.
Methods: Patients with OPFs treated at our hospital between March 2016 and February 2023 were retrospectively reviewed. Factors associated with PI were identified by logistic regression analysis.
Results: This study included 44 OPFs. In 50% (n=22) of these cases, the patients had PI. Gustilo grade-III ratio was much higher in the PI (81.8% [n=18]) than in the non-PI (36.4% [n=8]) group (p=0.008). Incidence of anorectal injury was higher in the PI group (68.2% [n=15] vs 13.6% [n=3], p=0.001). Multivariate logistic regression revealed age (odds ratio 1.02 [95% confidence interval 1.020–1.148], p=0.009), serum lactate level (1.319 [0.992–1.755], p=0.018), presence of Gustilo grade-III (7.467 [0.987–56.517], p=0.052), and anorectal injury (36.468 [3.107–427.991], p=0.004) as independent risk factors for PI. Hospitalisation stay, overall medical costs, and number of surgeries were 2.8 (84.0 vs 30.5 days, p=0.002), 2.9 (95.812 vs 33,224 USD, p=0.001), and 2.9 (13.0 vs 4.5, p<0.001) times higher in the PI than in the non-PI group, respectively.
Conclusions: Age, serum lactate levels, Gustilo-Anderson grade-III status, and presence of anorectal injury are the risk factors for PI in patients with OPFs. PIs are associated with high medical costs. Early wound management, precise antibiotic therapy, and early-multidisciplinary approaches are necessary to treat PIs and prevent sepsis.
Treatment of diabetic macular edema: Bibliometric analysis
Authors: Wang Shengzhan , Shen Wenyue , Wang Wenhao , Xin Shuanghua , Ren Weina , Jin Kai 
Published: January 2024

Abstract
Purpose
To comprehensively analyze and discuss the publications about treatment of diabetic macular edema (DME) following a bibliometric approach.
Methods
The publications on treatment of diabetic macular edema from 2014 to 2023 were retrieved from the Web of Science Core Collection (WoSCC) database. We analyzed the publication and citation trend over time and identified highly-cited articles, productive countries, institutions, journals and the most relevant research domains. VOSviewer was used to visualize the mainstream research topics and keywords.
Results
By analyzing a total of 1081 relevant publications, the number of annual publications showed an increasing trend over the last ten years, with the average growth rate of 15.15%. USA (290/1081), Italy (119/1081), China (110/1081) and Japan (99/1081) were the most productive countries. Retina-The Journal of Retinal and Vitreous Diseases was the most productive journal in this field. Johns Hopkins University (USA, 53/1047), Harvard University (USA, 34/1047), JAEB Center For Health Research (USA, 33/1047) and Assistance Publique Hopitaux Paris (France, 31/1047) were the most productive institutions. The analysis of keywords showed that “diabetic macular edema”, “ranibizumab”, “retinopathy”, “bevacizumab” and “endothelial growth-factor” were the most frequent keywords throughout the entire period.
Conclusion
This study summarized the recent advances in the treatment on diabetic macular edema. Most studies have focused on the therapeutic effects of anti-VEGF agents on DME. With the deepening of technology and research, more and more reasonable treatment methods will emerge.
Predicting Acute Brain Injury in Venoarterial Extracorporeal Membrane Oxygenation Patients with Tree-Based Machine Learning: Analysis of the Extracorporeal Life Support Organization Registry
Authors: Kalra Andrew , Bachina Preetham , Shou Benjamin L. , Hwang Jaeho , Barshay Meylakh , Kulkarni Shreyas , Sears Isaac , Eickhoff Carsten , Bermudez Christian A. , Brodie Daniel , Ventetuolo Corey E. , Kim Bo Soo , Whitman Glenn J. R. , Abbasi Adeel , Cho Sung-Min 
Published: January 2024

Abstract

Objective: To determine if machine learning (ML) can predict acute brain injury (ABI) and identify modifiable risk factors for ABI in venoarterial extracorporeal membrane oxygenation (VA-ECMO) patients.
Design: Retrospective cohort study of the Extracorporeal Life Support Organization (ELSO) Registry (2009-2021).
Setting: International, multicenter registry study of 676 ECMO centers.
Patients:
Adults (≥18 years) supported with VA-ECMO or extracorporeal cardiopulmonary resuscitation (ECPR).
Interventions: None.
Measurements and Main Results: Our primary outcome was ABI: central nervous system (CNS) ischemia, intracranial hemorrhage (ICH), brain death, and seizures. We utilized Random Forest, CatBoost, LightGBM and XGBoost ML algorithms (10-fold leave-one-out cross-validation) to predict and identify features most important for ABI. We extracted 65 total features: demographics, pre-ECMO/on-ECMO laboratory values, and pre-ECMO/on-ECMO settings.
Of 35,855 VA-ECMO (non-ECPR) patients (median age=57.8 years, 66% male), 7.7% (n=2,769) experienced ABI. In VA-ECMO (non-ECPR), the area under the receiver-operator characteristics curves (AUC-ROC) to predict ABI, CNS ischemia, and ICH was 0.67, 0.67, and 0.62, respectively. The true positive, true negative, false positive, false negative, positive, and negative predictive values were 33%, 88%, 12%, 67%, 18%, and 94%, respectively for ABI. Longer ECMO duration, higher 24h ECMO pump flow, and higher on-ECMO PaO2 were associated with ABI.
Of 10,775 ECPR patients (median age=57.1 years, 68% male), 16.5% (n=1,787) experienced ABI. The AUC-ROC for ABI, CNS ischemia, and ICH was 0.72, 0.73, and 0.69, respectively. The true positive, true negative, false positive, false negative, positive, and negative predictive values were 61%, 70%, 30%, 39%, 29% and 90%, respectively, for ABI. Longer ECMO duration, younger age, and higher 24h ECMO pump flow were associated with ABI.
Conclusions: This is the largest study predicting neurological complications on sufficiently powered international ECMO cohorts. Longer ECMO duration and higher 24h pump flow were associated with ABI in both non-ECPR and ECPR VA-ECMO.
Maternal perinatal noise exposure and risk of congenital heart disease: a case-control study in Northwest China
Authors: Yan Mingxin , Zhao Yan , Zhao Doudou , Sun Yuanhan , Wang Bin , Zhou Yan , Pei Leilei , Qu Pengfei 
Published: January 2024

Abstract
Background: In recent years, congenital heart disease (CHD) has emerged as the predominant birth defect. This study seeks to explore the correlation between maternal perinatal noise exposure and the occurrence of CHD in their offspring.
Methods:A case-control investigation encompassed 589 cases and 1193 controls, conducted in six tertiary hospitals in Xi'an, Shaanxi Province, Northwest China. The link between maternal periconceptional noise exposure and the occurrence of CHD in offspring was evaluated by estimating the odds ratio (OR) through a multifactorial logistic regression model. Additionally, we employed restricted cubic spline curves to delineate the nonlinear relationship between the duration of noise exposure and the incidence of CHD.
Results: After accounting for confounding variables, maternal periconceptional noise exposure demonstrated an association with an elevated risk of CHD in offspring (OR=1.81, 95% CI: 1.36,2.40). In comparison to pregnant women not exposed to noise, the duration of noise exposure was linked to an increased risk of CHD in offspring (4 ~ ≤8 hours/day: OR=3.24, 95% CI: 2.02,5.20; >8 hours/day: OR=2.07, 95% CI: 1.19,3.58), and exposure to various noise sources was associated with an augmented risk of CHD in offspring (traffic: OR=1.75, 95% CI: 1.20,2.56; construction and industrial production: OR=2.13, 95% CI: 1.29,3.50). The analysis using restricted cubic spline curves revealed a positive correlation between the duration of noise exposure and the risk of CHD. Furthermore, residing closer to a major traffic artery (≤50 meters) during pregnancy was linked to a heightened risk of CHD in the fetus (OR=2.30, 95% CI: 1.66,3.19). Similarly, proximity to a construction site (≤500 meters) was associated with an increased risk of CHD in the fetus (OR=1.98, 95% CI: 1.37,2.85).
Conclusions: The findings of our study indicate that maternal noise exposure during pregnancy elevates the risk of CHD in offspring. Furthermore, exposure to traffic and construction noise, and longer durations of noise exposure were more strongly associated with the risk of CHD in the offspring.
Simulations for in-flight stellar calibration aimed at monitoring space instruments optical performance
Authors: Casini Chiara , Chioetto Paolo , Comisso Antonela , Fabio Frassetto , Zuppella Paola , Deppo Vania Da 
Published: January 2024

Abstract
Stellar in-flight calibrations have a relevant impact on the capability of space optical instruments, such as telescopes or cameras, to provide reliable scientific products, i.e. accurately calibrated data. Indeed, by using the in-flight star images, instrument optical performance can be checked and compared with the on-ground measurements. The analysis of star images carried out throughout the entire lifetime of the instrument in space will enable tracking changes in instrument performance and sensitivity due to degradation or misalignment of the optical components.
In this paper, we present the concept, the necessary input and the available outputs of the simulations performed to predict the stars visible in the FoV of a specific space instrument. As an example of the method, its application to two specific cases, i.e. the Metis coronagraph on board Solar Orbiter and the stereo camera STC on board BepiColombo, will be given.
Due to their proximity to the Sun, and also to Mercury for STC, both instruments operate under hard conditions subjected to high temperatures and significant temperature variations. Therefore, performance optical monitoring is crucial.
Development and Evaluation of Potato Starch and Chitosan Modified Capecitabine Nanoparticles for Enhanced Colon Cancer Treatment: A Comprehensive Study on PhysicalProperties, In vitro Efficacy, and In vivo Targeting
Authors: Bhattacharya Sankha , Page Amit , Shinde Prafull 
Published: January 2024

Abstract
This study explores the innovative application of carbohydrate-based nanoparticles in aggressive colon cancer treatment. We synthesized Capecitabine (CTB) nanoparticles by conjugating them with potato starch and chitosan, utilizing the unique properties of these materials. CTB nanoparticles were meticulously fabricated through ultrasonication, hydrolysis with 0.1M NaOH, and ionotropic gelation. Characterization included drug loading, rheological studies, Surface-Enhanced Raman Spectroscopy (SERS), Fourier-Transform Infrared Spectroscopy (FTIR), Differential Scanning Calorimetry (DSC), X-ray Diffraction (XRD), and Thermogravimetric Analysis (TGA). Analysis of XRD and FTIR spectra revealed molecular disorder and crystallinity loss. Beyond physical characterization, we explored functional and antioxidant properties, showing promise with a mean particle size of 245±10.45nm, zeta potential +30.3±8.09 mV, leading efficacy 76.45±3.85%, and 92.25±5.78% drug release over 100 hours. Subsequently, we evaluated cytotoxicity against HT-29 cells in vitro and in vivo using N, N-dimethylhydrazine-induced male Balb/c mice. Capecitabine-loaded potato starch-chitosan (CTB-PS-CS) nanoparticles exhibited superior colon histology and lower tumour scores, highlighting their robust anticancer activity. CTB-PS-CS-NPs significantly reduced VEGD and CD31 compared to free CTB. We conducted various cellular assays, including tube-forming, wound-healing, crystal violet staining, and apoptosis studies, consistently demonstrating pronounced anticancer effects on HT-29 cells. Our study supports the enhanced anticancer activity of CTB-PS-CS-NPs, indicating their potential for assessing nanoparticle efficacy and compatibility across diverse cancer models.
Response of Nanosilica on Physiological and Leaf Surface Anotomical Characters in Rice under Drought
Authors: Surendar K. Krishna , Raja R. Karthik , Srith N. , Ravichandran V. , Kannan M. , Pushpam R. , Anitha R. , Priya R. Sathya , Yuvaraj M 
Published: January 2024

Abstract

The experimentation was carried out during the summer (2021–2022) at the Rice Department, Tamil Nadu Agricultural University, Coimbatore to assess the effects of nanosilica on drought imposed rice plants and to assess the impact of different concentrations of nanosilica (SiO2) on growth, anatomical, physio-biochemical parameters and yield characters of rice under drought conditions. In this experiment, different concentrations of the nanosilica formulation at 200, 400, 600, 800, and 1000 ppm were applied as foliar sprays under drought conditions. Spraying of 400 ppm of nanosilica formulation under drought stress in this field experiment has resulted of increases in leaf area and specific leaf weight of 14.3 and 15.3%, respectively. Application of 400 ppm nanosilica increases up to 12.5% in terms of membrane stability index (MSI), meanwhile in chlorophyll stability index (CSI) was increased up to 20.4%. Proline content was decreased up to 26.9% by application of nanosilica (400 ppm) in drought imposed treated plants. Trichome length and the length of the silica bodies were significantly increase of about 17.4 and 9.1% over the control. Application 400 ppm of nanosilica had maximum of 68.9 and 29.4% increment in terms of trichome and silicon bodies length over the drought. Stomatal structures are reduced significantly with mean reduction of 43.5% than the control in both the rice varieties. Under the drought, the average increase in stomatal size was 65.5% when 400 ppm nanosilica was applied. When exposed to 400 ppm of nanosilica treatments, CO54 showed more responses than the other variety in terms of leaf area, specific leaf weight, MSI, CSI, proline and leaf surface characteristics during drought.
Unveiling the viral escape: Quantification of microfloc-bound viruses in precoagulation and membrane filtration
Authors: Yasui Midori , Katayama Hiroyuki 
Published: January 2024

Abstract

The implementation of precoagulation before the physical removal process is expected to achieve a high virus removal rate. However, viruses may form small flocs and subsequently escape into the effluent during physical removal processes. This study evaluated how viruses in the microflocs could be quantified using conventional virus quantification methods (plaque assay and quantitative polymerase chain reaction (qPCR)) to reveal the risk of underestimating virus concentration. In this study, the microfloc dissolution phenomenon in phosphate buffer solution was employed as a floc dissolution test. Viruses in microflocs formed under the experimental conditions. assuming water treatments, were quantified before and after floc dissolution. The findings revealed that virus concentrations increased by 1.0–3.9 log plaque-forming units/mL according to the plaque assay and by 1.7–4.0 log copies/mL according to the qPCR. This increase occurred after the dissolution of microflocs that were prepared in the humic acid test water. In the case of treated wastewater, virus concentrations increased in all samples according to the plaque assay and in seven of eight samples according to the qPCR. Our results indicate the necessity of careful consideration of virus quantification after precoagulation and physical removal systems.