bluuebunny/crossref_metadata_2025_split huggingface dataset:
A prospective comparison study utilizing patient-reported outcomes of taxane-related peripheral neuropathy between nab-paclitaxel and standard paclitaxel in patients with breast cancer
Authors: Kida Kumiko , Yamada Akimitsu , Shimada Kazuhiro , Narui Kazutaka , Sugae Sadatoshi , Shimizu Daisuke , Doi Takako , Oba Mari , Endo Itaru , Ishikawa Takashi 
Published: October 2023

Abstract

Background: Characteristics of taxane-induced peripheral neuropathy (PN) could be different between paclitaxel and nab-paclitaxel. The purpose of this prospective observational multicenter cohort study was to compare tri-weekly nab-paclitaxel to weekly standard paclitaxel regarding the severity, onset and recovery of sensory and motor PN in patients with breast cancer.
Methods: Patients with histologically confirmed breast cancer who were scheduled to receive standard weekly paclitaxel (80 mg/m2) or tri-weekly nab-paclitaxel (260 mg/m2) at institutions in our multicenter group were eligible for this study. Sensory and motor PN were evaluated every 3 weeks until PN improved for up to one year using patient-reported outcome.
Results: Between February 2011 and April 2013, 115 patients were enrolled, including 57 and 58 in the paclitaxel and nab-paclitaxel groups, respectively. The incidence of moderate or severe sensory PN was not significantly different between the two groups (p=0.40). The incidence of moderate or higher motor PN was more frequent in the nab-paclitaxel group than in the paclitaxel group (p=0.048). The median period for demonstrating PN were shorter in the nab-paclitaxel group than in the paclitaxel group (sensory, p=0.003; motor, p=0.001). The recovery of motor PN was slower in the nab-paclitaxel group than in the paclitaxel group (p=0.035), while the recovery period of sensory PN was not statistically different.
Conclusion: Nab-paclitaxel induced sensory PN sooner than paclitaxel, and no difference was observed in the severity and recovery duration between the two agents. Motor PN was more severe, started sooner, and improved over a longer period in the nab-paclitaxel-treated patients than in the paclitaxel-treated patients.
Proper prognostic classification of histopathologic response to neoadjuvant chemoradiotherapy in esophageal squamous cell carcinoma
Authors: Liu Guihong , Zhang Xin , Chen Tao , Tang Yu , Hu Binbin , Shi Huashan 
Published: October 2023

Abstract
Background
Accurate restaging and histological assessment of esophageal squamous cell carcinoma (ESCC) after neoadjuvant chemoradiotherapy (nCRT) provide valuable prognostic information. We aimed to elucidate proper classification methods to discriminate and predict prognosis in ESCC patients who received nCRT followed by surgery and in the recurrent subgroup.
Methods
We included 309 patients with ESCC who underwent nCRT followed by complete resection for analysis of overall survival (OS). Among them, 304 patients were eligible for recurrence-free survival (RFS) analysis, and OS analysis was also separately performed on 98 recurrent patients. Tumor regression grade (TRG) was assessed using the modified Ryan scheme and ypTNM was recorded based on the 8th edition of the AJCC TNM classification. The combination of TRG and lymph node status resulted in two ypTN systems: ypTN (four categories) and ypTN (three categories). In the ypTN (four categories) system, the categories were ypT-N-, ypT + N-, ypT-N+, and ypT + N+. When considering ypT + N- and ypT-N + as one category, it produced the ypTN (three categories) system. We plotted Kaplan-Meier survival curves based on various classification methods. The log-rank test was used to examine differences in survival rates and calculate P values. The selected classification methods underwent univariable and multivariable Cox regression analyses.
Results
The mean follow-up period was 39.2 months (range, 0.6–70.4). Compared to classification methods of TRG, ypT, ypN, ypTNM, and ypTN (four categories), ypTN (three categories) performed the best ability to distinguish and predict OS and RFS in overall population with P < 0.001 for overall models and significant differences between adjacent groups. In the recurrent population, we found the binary classification of ypN was a good predictor of OS (ypN- vs. ypN+, HR: 1.819, 95%CI: 1.150–2.878, P = 0.011). The reliability of these classification methods in both the overall population and the recurrent population was confirmed by univariable and multivariable Cox regression analyses.
Conclusions
The prognosis of ESCC patients who received nCRT followed by surgery can be distinguished and predicted by ypTN (three categories) system. Lymph node status was an ideal prognostic classification for the recurrent subgroup.
A Geographically Weighted Regression analysis of the underlying factors of Urban Heat Island phenomenon in Ghaziabad district of Uttar Pradesh
Authors: . Diksha , Kumari Maya , Rai Praveen Kumar , Kumar Deepak 
Published: October 2023

Abstract
Urbanization is important for societal development. However, it is accompanied by environmental concerns, such as a rise in the temperature of the local area in comparison to that of its surroundings; this phenomenon is known as an Urban Heat Island (UHI). The purpose of this study is to model UHI in the Ghaziabad district using Temperature of the Land's Surface (LST) for the Years 2011 and 2012, estimated from Landsat 7 and 8 respectively, using ArcGIS and SAGA GIS software. The results show that the mean LST increased by 3.11°C over the course of a decade. The Urban Thermal Field Variance Index (UTFVI) was used to map and characterise regions that had high UHI intensities. The areas with high UHI intensity were typically residential areas whereas the low intensity was found associated with cropland. In the Ordinary Least Squares Regression (OLS) regression model, Surface Albedo (SA), Sky View Factor (SVF), Solar Radiation (SR), and Normalized Difference Vegetation Index (NDVI) accounted for 58% of LST variability in 2011 and 66% in 2021. Because LST is nonstationary, a Geographically Weighted Regression (GWR), was utilised to demonstrate that the residuals are normally and randomly distributed.
Occlusal and masticatory aspects after application of Hall technique and conventional SSC – an 8 weeks comparative cohort study
Authors: He Pengcheng , Li Yiting , Wang Siwei , Zhou Xin , Zhou Yuan , Zheng Liwei 
Published: October 2023

Abstract
Objectives
By comparing the differences between Hall technique and traditional preformed mental crowns(PMC) in the treatment of extensive caries, this paper aims to investigate the treatment efficacy of Hall technique.
Materials and Methods
①Chlidren who needed metal crown restoration due to caries of mandibular deciduous molars, were selected. Oral dates were measured and analyzed in pre-op, post-op,2wk post-op, 4wk post-op and 8wk post-op.②Rebuild and compare the treatment modules through three-dimensional finite element analysis.
Results
①There were 21 (12males and 9 females) in the Hall technique group and 22(15 males and 7 females) in the traditional PMC group. All data with Hall technique changed immediately after operation, and returned to the preoperative level at 2wk post-op and 4wk post-op (P > 0.05). ②In treatment modules, the maximum stress value of Hall technique module increased immediately, and returned to the preoperative level.
Conclusion
After the Hall technique treatment, the occlusal state will gradually return to the preoperative state in about 2–4 weeks. The occlusal and masticatory prognosis is not significantly different from that of the traditional PMC technique.
Clinical Relevance:
This investigation demonstrates Hall technique’s safety in periodontitis and temporomandibular joint and effectiveness stopping caries developing.
Registration number: ChiCTR2100046097
Effective, versatile and inexpensive extruder system for direct ink writing of high-viscosity pastes
Authors: Rodríguez-Lagar Pablo , Reguera-García Alejandro , Llamas-Unzueta Raúl , Blanco Clara , Santamaría Ricardo , Montes-Morán Miguel A. , Menéndez J. Angel , Rocha Victoria G. 
Published: October 2023

Abstract
We offer the possibility of implementing a lab made extruder for direct ink writing (DIW) into a conventional fused deposition modelling (FDM) 3D printer. The ink extruder was designed to comply with various requirements including the possibility of using multiple syringe volumes, ease of assembly, compatibility with numerous commercial FDM printers, ink retraction and ink flow control, and the ability to extrude inks with a wide range of viscosities (ink yield stresses from 135–1100 Pa). The load in the extruder was attained by combining a stepper motor and a gear reduction system. The reduction system was connected to a trapezoidal threaded spindle through a rigid coupler. The movement of the spindle was transmitted to the plunger of a syringe that contained the ink (with volumes ranging from 3–30 mL), by means of a linear guide system. Most of the extruder parts were printed with the same FDM printer to which the DIW extruder ended attached to. The DIW extruder wiring connections were simply made by using the E-axis connectors available in the FDM printer. Modifications of the FDM printer software required for the correct control of the DIW extruder were also relatively simple, avoiding firmware modification. This simplicity made the two DIW and FDM heads easily interchangeable, thus amplifying the functionality of a conventional FDM printer. The cost of this new DIW extruder is approx. 100€.
Pelvic girdle pain in pregnancy and early postpartum – prevalence and risk factors in a multiethnic cohort
Authors: Robinson Hilde Stendal , Vøllestad Nina K , Bennetter Karin Elisabeth , Waage Christine Wiegels , Jenum Anne Karen , Richardsen Kåre Rønn 
Published: October 2023

Abstract
Background. Pelvic girdle pain (PGP) is common during and after pregnancy. It has been assumed that Scandinavian women report more PGP than women of other ethnicities. However, there are few population-based studies on ethnic differences and few with ethnicity as risk factor for PGP. The purposes of the present study were: To examine the prevalence of self-reported PGP through pregnancy and early postpartum in a multiethnic cohort. To investigate how ethnicity and patient characteristics were associated with risk of PGP during pregnancy and early postpartum. To investigate if clinical and personal factors obtained in gestation week 15 were associated with PGP in gestation week 28 and postpartum week 14.
Methods. This study analyzed questionnaire data from 823 women from the Stork- Groruddalen multiethnic cohort study in Norway. Chi-square tests were used to investigate ethnic differences in prevalence of self-reported PGP, and logistic regression analyses to identify factors associated with self-reported PGP.
Results. Women from South-Asia and Middle East reported 10-20% higher prevalence of self-reported PGP at all time points compared with Western women. Ethnicity was associated with PGP in gestation week 15 and postpartum week 14, adjusted for parity. Pain locations in pelvic area (PGP locations) in gestation week 15, especially combined symphysis and posterior pelvic girdle pain, gave the highest risk (OR=7.4) for PGP in gestation week 28 and in postpartum week 14(OR = 3.9). Being multiparous was a risk for PGP in postpartum week 14 (OR=1.9).
Conclusions. Women of South Asian and Middle Eastern background had higher risk of self-reported PGP than Western women. Ethnicity was associated with PGP in gestation week 15 and postpartum week 14, after adjustments for parity. PGP locations in gestation week 15 was the most prominent risk factor for PGP in gestation week 28 and postpartum week 14, whilst ethnicity was not significant in multivariable analyses.
Affiliate stigma and caring burden among primary caregivers of adult patients with severe mental illness: a facility-based cross-sectional study
Authors: Handebo Frehiwot , Kassim Faiz Mohammed , Alemayehu Selamawit , Amare Hermon 
Published: October 2023

Abstract
Introduction: Although caregivers play an important role in the treatment and recovery of various patients, several studies showed that primary caregivers of adults with severe mental illness (AWSMI) experience widespread stigma and have a high burden. However, there are limited studies in developing countries that assessed stigma and burden among primary caregivers of AWSMI.
Objectives: The present study aimed to assess affiliate stigma and caring burden among caregivers of AWSMI at St. Paul’s Hospital Millennium Medical College(SPHMMC), Addis Ababa, Ethiopia.
Methods: A facility-based cross-sectional study design was applied. A total of 375 caregivers of AWSMI were recruited using a systematic random sampling technique. Data were collected usinga systematic random sampling method. The collected data includes tools and structured questionnaires including the family stigma scale, attitude toward mental illness questionnaire, family burden interview, Oslo 3-items social support scale, sociodemographic and clinical characteristics of the caregivers and the patients, and burden of caregivers. Descriptive and binary logistic regression were performed to analyze the data.
Results: Caregivers (n =375) of patients with bipolar disorder (n = 50), anxiety disorders (n= 82), MDDs (n =103) and schizophrenia (n = 140) participated in the study, with a response rate of 95.7%. Half of the participants (187) were female. The results showed that around half (54.9%) of the caregivers experienced or perceived stigma. The factors that were associated with stigma among caregivers were caregiving patients with schizophrenia (AOR: 1.91; 95% CI: 0.86, 4.2; p = 0.003), attitude towards people with mental illness (AOR: 2.1; 95% CI: 1.23, 3.4; p = 0.005), social support (AOR: 0.5; 95% CI: 0.30, 0.82; p = 0.006), patient history of psychiatric admission (AOR: 0.32; 95% CI: 0.18, 0.57; p < 0.0001) and superstitious belief (AOR: 0.28; 95% CI: 0.15, 0.52; p < 0.0001). The findings also illustrated that a large proportion of caregivers (89%) had moderate to severe burden.
Conclusions: Overall, the current findings showed that stigma and burden among caregivers of AWSMI are high, indicating the urgent need to provide interventions such as psycho-education and contextualized support for caregivers and improving public’s awareness about mental illness. Furthermore, types of illness, social support, attitude towards people with mental illness, patient history of psychiatric admission and superstitious beliefs are important determinants of stigma.
Research on Community Perception Based on Street View Data Scoring Strategy
Authors: Pan Lu , Wan Yunshan , Xu Xiansheng , Li Qingyun 
Published: October 2023

Abstract
People are the main users of community street space. How to quantify street space quality from the perspective of people's perception and explore the relationship between street space quality and street elements has been a topic devoted to research in various fields. The development of big data and computer science provides a new technique for quantitative evaluation of street perception. The downtown area of Haikou city was taken as the research object to verify the method of this study. Street images of this area were used to construct a deep learning scoring model, and six dimensions of beauty, rich, safety, energetic, repression and [1] boredom were used to score perceptions. The six dimensions of perception are further divided into positive perception and negative perception. The top 20% of streetscape with the highest positive perception score was regarded as high-quality street space, while the top 20% of streetscape with the highest negative perception score was regarded as low-quality street space. The results showed that the highly urbanized area (Longhua district) was considered to be safer and more energetic, but at the same time, with higher sense of depression, there were significant differences incommunity perception among different types of POI, and community green space could significantly relieve the perception of depression. Therefore, this paper confirms the key role of urban functions in promoting sustainable urban development from the perspective of subjective perception, and provides scientific support for planning policies in terms of infrastructure service supply. By exploring the correlation between urban perception and urban functional pattern, this study finds that there is a strong nonlinear relationship between urban perception and urban functional structure. The case study quantitatively determines the impact of urban functions on city perception and illustrates the effectiveness of the proposed deep learning scoring method in promoting city perception evaluation.
The Invasion of Ukraine Viewed through TikTok: A Dataset
Authors: Steel Benjamin , Parker Sara , Ruths Derek 
Published: October 2023

Abstract
We present a dataset of video descriptions, comments, and user statistics, from the social media platform TikTok, centred around the invasion of Ukraine in 2022, an event that launched TikTok into the geopolitical arena. User activity on the platform around the invasion exposed myriad political behaviours and dynamics previously unexplored on this platform. To this end, we provide a mass-scale language and interaction dataset for further research into these processes. In this paper we conduct an initial investigation of language and social interaction dynamics, alongside an evaluation of bot detection on the platform. We have open-sourced the dataset and the library used to collect it to the public.
γ-polyglutamic Acid Application to Grassland on Sandy Soil: the Effect on Soil and Plant Functional Traits in Relation to Drought Stress
Authors: Skalski Tomasz , Zając Ewelina , Jędrszczyk Elżbieta , Papaj Katarzyna , Kohyt Joanna , Góra Artur , Kasprzycka Anna , Shytum Divine , Skowera Barbara , Ziernicka-Wojtaszek Agnieszka 
Published: October 2023

Abstract
The current study provides field experimental data that support the use of γ-polyglutamic acid (γ-PGA) in drought stress and proposes its application in grassland management. We hypothesized that water treatment combined with PGA application to sandy soil would reduce drought stress in grasslands more effectively than watering alone. A randomized block design was used, with three replicate watering blocks (no watering, weekly watering, and monthly watering) and PGA treatments at four different concentrations (0%, 0.3%, 1%, and 2% PGA). The results showed that PGA acts as a biostimulant, alleviating the effects of stress in plants by: 1) increasing the availability of ions, especially K+, Zn2+, Mn2+, Fe2+/3+, Ca2+, and Mg2+, as well as N-NH4+, and N-NO3−, 2) elongating plant roots, 3) increasing the aboveground biomass, 4) improving the resprouting capacity of the dominant grass Nardus stricta, and 5) improving the regeneration of dicotyledons. In the case of meadows on sandy soils, the use of low PGA concentrations (0.3% or 1%) was the most beneficial for the availability of macro- and microelements and improving the functional traits of plants. Irrigation had a greater effect than using PGA only for the dicotyledon to monocotyledon ratio.
Analysis of Cell-Free DNA to Predict Outcome to Bevacizumab Combination Therapy in Metastatic Colorectal Cancer Patients
Authors: Byrne Annette , Venken Tom , Miller Ian , Arijs Ingrid , Thomas Valentina , Barat Ana , Betge Johannes , Zhan Tianzuo , Gaiser Timo , Ebert Matthias , O'Farrell Alice , Prehn Jochen , Klinger Rut , O'Connor Darran , Moulton Brian , Murphy Verena , McDermott Ray , Bird Brian , Leonard Gregory , Grogan Liam , Horgan Anne , Schulte Nadine , Moehler Markus , Lambrechts Diether 
Published: October 2023

Abstract

To predict outcome to combination bevacizumab (BVZ) therapy, we employed cell-free DNA (cfDNA) to determine chromosomal instability (CIN), nucleosome footprints (NF) and methylation profiles in metastatic colorectal cancer (mCRC) patients.
Low-coverage whole-genome sequencing (LC-WGS) was performed on matched tumor and plasma samples, collected from 74 mCRC patients from the AC-ANGIOPREDICT Phase II trial (NCT01822444), and analysed for CIN and NFs. A validation cohort of plasma samples from the University Medical Center Mannheim (UMM) was similarly profiled. 61 AC-ANGIOPREDICT plasma samples collected before and following BVZ treatment were selected for targeted methylation sequencing.
Using cfDNA CIN profiles, AC-ANGIOPREDICT samples were subtyped with 92.3% accuracy into low and high CIN clusters, with good concordance observed between matched plasma and tumor. Improved survival was observed in CIN-high patients. Plasma-based CIN clustering was validated in the UMM cohort. Methylation profiling identified differences in CIN-low vs. CIN high (AUC = 0·87). Moreover, significant methylation score decreases following BVZ was associated with improved outcome (p = 0·013).
Analysis of CIN, NFs and methylation profiles from cfDNA in plasma samples facilitates stratification into CIN clusters which inform patient response to treatment
Stock market prediction using the LSTM algorithm in association with the Relative Strength Index (RSI) and Exponential Moving Average (EMA) indicators.
Authors: Dhokane Rahul Maruti , Agarwal Sohit 
Published: October 2023

Abstract
Because of the unpredictable nature of the financial market, stock prediction is very difficult. To invest investors' hard-earned money in the financial market, we require additional information. Traditional models like linear regression and Support Vector Regression (SVR) are used to predict stock prices, but they do not have much accuracy. Recurrent Neural Network (RNN) is having "vanishing gradient" issues. In this study, we explain the technique of combining the Long Short-Term Memory (LSTM) machine learning algorithm with leading indicators like the Relative Strength Index (RSI) and the Exponential Moving Average (EMA), i.e., the slow EMA, medium EMA, and fast EMA. For this study, we have selected seven different stocks from the National Stock Exchange (NSE), and the dataset period is from January 1, 2012, to December 31, 2022. When we add extra features like RSI, 50-day EMA, 100-day EMA, and 150-day EMA to traditional ones like open, high, low, close, and volume, we get better results than when we only use traditional ones like open, high, low, close, and volume. When the indicators are added along with the traditional features, the Mean Absolute Percentage Error (MAPE) goes down, the R2 score (coefficient of determination) goes up, and the model does better than the conventional model. This study and analysis helps to improve intraday trading by predicting the value and trend of certain stocks.