bluuebunny/crossref_metadata_2025_split huggingface dataset:
Inter-individual variation of inflammatory markers of cardiovascular risks and diseases
Authors: Berrahmoune Hind , Lamont John , Fitzgerald Peter , Visvikis-Siest Sophie 
Published: August 2005

AbstractCardiovascular diseases are a real public health problem and have multifactorial origin. Full comprehension of these diseases is very difficult because of their clinical and biological heterogeneity. The best way to understand the development of these diseases is to first investigate each biological system involved in the diseases and secondly, interactions between them. Studying intermediate phenotype variation for these biological systems is a new and promising approach for their elucidation. Among these metabolic systems, inflammation is known to be implicated in the occurrence and worsening of cardiovascular diseases. For this review, we chose to report the most important results concerning environmental, genetic and epigenetic determinants that influence intermediate phenotypes (protein and RNA levels) of inflammation. Indeed, numerous studies have investigated these determinants in healthy populations, in other words, without the influence of either disease or medication. This new approach will help to better understand the regulation of these intermediate phenotypes and to identify a panel of risk markers, which may be useful in predicting and warning those at risk and in giving adequate treatment to each patient.
“Coelionomics”: towards understanding the molecular pathology of coeliac disease
Authors: Diosdado Begoña , van Oort Erica , Wijmenga Cisca 
Published: August 2005

AbstractCoeliac disease (CD) is an inflammatory disorder of the small intestine characterised by a permanent intolerance to gluten-derived peptides. When gluten-derived peptides reach the lamina propria in CD patients, they provoke specific changes in the mucosa of their small intestine. Although the susceptibility to CD is strongly determined by environmental gluten, it is clearly a common genetic disorder. Important genetic factors for CD are the
A common CYP1B1 polymorphism is associated with 2-OHE1/16-OHE1 urinary estrone ratio
Authors: Paracchini Valentina , Pedotti Paola , Raimondi Sara , Garte Seymour , Bradlow H. Leon , Sepkovic Daniel W. , Taioli Emanuela 
Published: August 2005

AbstractCytochrome P450 (CYP) is a multigene family of enzymes involved in important life functions; some of these genes are inducible and are implicated in the oxidative metabolic activation and detoxification of many endogenous and exogenous compounds.
Quantitative measurement of ketone bodies in urine using reflectometry
Authors: Penders Joris , Fiers Tom , Giri Mimi , Wuyts Birgitte , Ysewyn Larissa , Delanghe Joris R. 
Published: August 2005

AbstractBackground: Recently, automated urine test strip readers became available that can report quantitative data. We explored the possibility of measuring all ketone bodies (acetone, acetoacetate, 3-hydroxybutyrate) in urine with these test strips. Monitoring urinary ketone concentrations could offer the advantages of measuring higher values (due to the low renal thresholds) and being less sensitive to fluctuations.Methods: We evaluated URISYS 2400 (Roche) quantitative reflectance data for the ketone reflectance field and compared it with biochemical data from urine samples. Using an easy sample pre-treatment with 3-hydroxybutyrate dehydrogenase, we were able to assay 3-hydroxybutyrate as well, which normally does not react on urine test strips.Results: Within- and between-run reproducibility of the reflectance signal for high- and low-concentration urine pools was 11.0–3.6% and 11.0–5.8% for aceto-acetate, 8.2–9.2% and 10.4–16.1% for acetone, and 5.1–3.0% and 5.6–3.5% for 3-hydroxybutyrate, respectively. The lower limit of detection for acetoacetate was 0.13mmol/L (CV=3.6%). Fair agreement was obtained between test strip data for ketones andcolorimetrically determined acetoacetate values (r=0.90).Conclusions: In urine test strip analysis, quantitative ketone reflectance data allow a simple and fast analysis, offering affordable screening for the detection of ketone body production in diabetes, especially in emergency settings.
Determination of the antioxidant capacity in blood
Authors: Fischer Marc A. J. G. , Gransier Theo J. M. , Beckers Lenie M. G. , Bekers Otto , Bast Aalt , Haenen Guido R. M. M. 
Published: August 2005

AbstractBackground: A vast amount of scientific research is directed towards the beneficial effects of antioxidants on health. For this reason, several assays have been developed to determine the total antioxidant capacity of blood. Methods: In this study two procedures based on the use of the green-blue 2,2′-azino-bis(3-ethylbenzthiazoline-6-sulfonic acid) radical (ABTS
Circadian variation of holo-transcobalamin (holo-TC) and related markers
Authors: Hvas Anne-Mette , Højbjerg Gravholt Claus , Nexo Ebba 
Published: August 2005

AbstractWe examined the circadian variation of holo-transcobalamin (holo-TC), total transcobalamin (total TC) and plasma cobalamins, and the association between food intake and fluctuations in the biochemical markers. A total of 17 healthy women (mean age 33years; range 24–40) participated. The subjects were admitted at 08:00h after an overnight fast, and blood samples were obtained every 20min for 24h from 12:00h. Holo-TC and total TC were measured by an ELISA, and plasma cobalamins were measured by a routine method (Centaur, Bayer). All subjects, except one, had 12:00h levels within the reference interval for all variables studied, and all subjects had normal renal function as judged from plasma creatinine. We found a small intra-individual variation (12%, 10%, 10%) and a considerable inter-individual variation (56%, 26%, 43%) in the level of holo-TC, total TC and plasma cobalamins, respectively. During the night, the absolute values of all components decreased, as did plasma albumin. There was no systematic association between intake of food and fluctuation of the biochemical markers. In conclusion, we found no significant circadian variation in serum holo-TC in healthy vitamin-replete subjects on a standard diet. This supports the view that holo-TC is a marker of long-term vitamin B
Evaluation of the ABX Pentra 400: a newly available clinical chemistry analyser
Authors: Coudène Pascal , Marson Benjamin , Badiou Stéphanie , Flavier Sébastien , Anelli Sébastien , Cristol Jean Paul , Dupuy Anne Marie 
Published: August 2005

AbstractThe performance of the ABX Pentra 400, a new multiparametric analyser available for routine and specialised clinical chemistry analyses, was evaluated according to the National Committee for Clinical Laboratory Standards (NCCLS) and Valtec protocols. Substrate concentrations and enzyme activities were determined by spectrophotometric measurement after coloured reaction or UV detection-based reactions; electrolyte concentrations were determined with ion-selective electrodes, and specific protein concentrations were assayed by immunoturbidimetry. In total, 32 of the most common clinical chemistry parameters were evaluated under simulated routine conditions. The analytical performance of the system and the quality of the ABX Pentra reagent line were both examined in a single-site study. The ABX Pentra 400 was compared with the Olympus AU640, Konelab-Konepro, Beckman Coulter-Immage and Beckman Coulter-Access 2, depending on the tests available on these analysers. The coefficient of variation (CV) values were within expected values. Coefficients of correlation showed high correlation between the analysers compared. The influence of interfering substances was moderate. The practicability of the system was good. We conclude that good reliability and practicability make the ABX Pentra 400 system suitable for laboratories with various needs.
Haplotype analysis of the COMT‐ARVCF gene region in Israeli anorexia nervosa family trios
Authors: Michaelovsky Elena , Frisch Amos , Leor Shani , Stein Daniel , Danziger Yardena , Carel Cynthia , Fennig Silvana , Mimouni Marc , Klauck Sabine M. , Benner Axel , Poustka Annemarie , Apter Alan , Weizman Abraham 
Published: August 2005

AbstractAnorexia nervosa (AN) is a severe and complex psychiatric disorder with a significant genetic contribution. Previously, we found an association between AN and the 158Val/Met polymorphism of the catechol‐O‐methyltransferase (COMT) gene in a family‐based study of 51 Israeli AN trios. In the present study, we extended the original sample to include 85 family trios [66 AN restricting (AN‐R) and 19 bingeing/purging (AN‐BP) subtype] and performed a family‐based transmission disequilibrium test (TDT) analysis for five SNPs in the COMT and two in the adjacent ARVCF gene. Association was found between AN‐R and several SNPs in the COMT‐ARVCF region including the 158Val/Met polymorphism. TDT analysis of 5‐SNP haplotypes in AN‐R trios revealed an overall statistically significant transmission disequilibrium (P < 0.001). Specifically, haplotype B [COMT‐186C‐408G‐472G(158Val)‐ARVCF‐659C(220Pro)‐524T(175Val)] was preferentially transmitted (P < 0.001) from parents of AN‐R patients to their affected daughters, while haplotype A [COMT‐186T‐408C‐472A(158Met)‐ARVCF‐659T(220Leu)‐524C(175Ala)] was preferentially (P = 0.01) not transmitted. Haplotype B was associated with increased risk (RR 3.38; 0.95CI 1.98–6.43) while haplotype A exhibited a protective effect (RR 0.40; 0.95CI 0.21–0.70) for AN‐R. Preferential transmission of the risk alleles and haplotypes from the parents was mostly contributed by the fathers. No significant transmission disequilibrium of alleles or haplotypes was found for AN‐BP trios. The risk and protective haplotypes may carry molecular variations in the COMT gene or its vicinity that are relevant to the pathophysiology of restrictive anorexia nervosa in the Israeli‐Jewish population. © 2005 Wiley‐Liss, Inc.
Influencing product lifetime through product design
Authors: van Nes Nicole , Cramer Jacqueline 
Published: August 2005

AbstractThis article investigates the possibility of influencing product lifetime through product design. First, the results of a literature study on consumer behavior are presented. These show that surprisingly few researchers have focused specifically on the arousal of the need to replace a product. Therefore, empirical data about motives for product replacement were acquired through a combination of qualitative investigation and a quantitative survey. This resulted in a model of factors influencing the replacement decision and in a replacement typology. Finally, possible design directions for longer lasting products were explored. It was concluded that despite the variety of replacement motivations people basically want a well functioning and up to date product that meets their altering needs. This requires the development of dynamic and flexible products, which implies designing for variability and product attachment and preparing the product for future repair or upgrading. Copyright © 2005 John Wiley & Sons, Ltd and ERP Environment.
Design, lifestyles and sustainability. Aesthetic consumption in a world of abundance
Authors: Dobers Peter , Strannegård Lars 
Published: August 2005

AbstractThis paper strives for a conceptualization of sustainability, design and contemporary consumption. By sketching out how effective production systems have created an abundance of products, the paper links this development to the aestheticization of society and an increased interest in design. In market economies characterized by profusion, corporations engage in activities filling their offerings with aura, aesthetics, symbols and meaning. In such lands of plenty, conspicuous consumption becomes a thoroughly expressive activity and highly problematic for actors with ambitions to design a sustainable future. Our conclusion is that sustainability must ultimately be seen as intertwined with social processes such as fashion, identity and identity construction. Copyright © 2005 John Wiley & Sons, Ltd and ERP Environment.
Effect of HCV infection on THP‐1 monocytoid cells
Authors: Ponzetto A. , Gennero L. , Cutufia M. , Beltramo T. , Enrietto M. , Pescarmona P. , Pugliese A. 
Published: August 2005

AbstractHepatitis C virus (HCV) is the main cause of hepatocellular carcinoma in industrialized countries. HCV–HIV‐1 co‐infection occurs frequently among users of illicit intravenous drugs, thereby increasing the severity of HIV disease and the evolution of chronic active hepatitis towards cirrhosis and hepatocellular carcinoma. The present work shows that THP‐1 monocytoid cells are susceptible to HCV infection, of strain 1b, and that this strain can induce cellular modifications in this cell line. Infection of HCV was demonstrated by positivity for the E2 antigen within THP‐1 cells and by indirect immunofluorescence; moreover, HCV‐RNA was detected in supernatants of THP‐1 cells from day 7 post‐inoculation. Cell shape and membrane surface antigens varied upon viral infection, which is also capable of inducing oxygen radicals. In particular we underline the relevant intracellular accumulation of ferritin that paralleled an increase of cell surface expression of the transferrin receptor. Evaluation of cellular events upon HCV infection in THP‐1 cells may represent a useful tool with which to identify alteration in monocytes metabolism and to study therapeutic approaches for such alterations. Copyright © 2004 John Wiley & Sons, Ltd.
Synthesis of Glycopeptides from Type II Collagen‐Incorporating Galactosylated Hydroxylysine Mimetics and Their Use in Studying the Fine Specificity of Arthritogenic T Cells
Authors: Marin Julien , Blaton Marie‐Agnès , Briand Jean‐Paul , Chiocchia Gilles , Fournier Catherine , Guichard Gilles 
Published: August 2005

AbstractFive analogues of the bovine type II collagen (bCII) immunodominant glycopeptide [β‐D‐Gal‐(5R)‐5‐Hyl264]CII(256–270) (1) carrying diverse modifications at the critical hydroxylysine (Hyl) 264 side chain were designed and synthesised, to explore the fine specificity of bCII‐reactive T cells involved in the initiation and/or regulation of collagen‐induced arthritis (CIA), a mouse model for rheumatoid arthritis (RA). β‐D‐Galactosyl‐(5R)‐5‐hydroxy‐L‐lysine (19) and corresponding mimetics (22–25), conveniently protected for solid‐phase synthesis, were all obtained by a divergent route involving enantiopure 5‐hydroxylated 6‐oxo‐1,2‐piperidinedicarboxylates as the key intermediates. All three bCII‐specific T hybridomas used, as well as a recurrent pathogenic CD4+ T‐cell clone isolated from bCII‐immunised DBA/1 mice, recognised the galactosylated form 1 of the immunodominant bCII (256–270) epitope. These cells were extremely sensitive to changes at the ε‐amino group of Hyl264, but differed in their pattern of recognition of analogues with a Hyl264 side chain modified at C‐5 (i.e. inversion of stereochemistry, methylation). These data further document the importance of collagen post‐translational modifications in autoimmunity and in the CIA model in particular, and provide a new insight into the molecular interaction between glycopeptide 1 and the TCR of pathogenic T cells.
Ternary Compounds Ce0.67Pt2Al5 and Ce1.33Pt3Al8.
Authors: Murashova E. V. , Tursina A. I. , Bukhan'ko N. G. , Gribanov A. V. , Chernyshev I. V. , Seropegin Yu. D. 
Published: August 2005

AbstractFor Abstract see ChemInform Abstract in Full Text.
Intramolecular [4 + 2] Cycloadditions of 1,3‐Enynes or Arylalkynes with Alkenes with Highly Reactive Cationic Phosphine Au(I) Complexes.
Authors: Nieto‐Oberhuber Cristina , Lopez Salome , Echavarren Antonio M. 
Published: August 2005

AbstractFor Abstract see ChemInform Abstract in Full Text.
Intermolecular Tandem Pd‐Catalyzed Cross‐Coupling/[4 + 4] and [4 + 2] Cycloadditions: A One‐Pot, Five‐Component Assembly of Bicyclo[6.4.0]dodecanes.
Authors: Lee Phil Ho , Lee Kooyeon 
Published: August 2005

AbstractFor Abstract see ChemInform Abstract in Full Text.
Sterically Congested “Roofed” 2‐Thiazolines as New Chiral Ligands for Copper(II)‐Catalyzed Asymmetric Diels—Alder Reactions.
Authors: Yamakuchi Manabu , Matsunaga Hirofumi , Tokuda Ryoh , Ishizuka Tadao , Nakajima Makoto , Kunieda Takehisa 
Published: August 2005

AbstractFor Abstract see ChemInform Abstract in Full Text.
Proline‐Catalyzed Asymmetric Aldol Reaction Between Methyl Ketones and 1‐Aryl‐2,2,2‐trifluoroethanones.
Authors: Qiu Li‐Hua , Shen Zong‐Xuan , Shi Chang‐Qing , Liu Yan‐Hua , Zhang Ya‐Wen 
Published: August 2005

AbstractFor Abstract see ChemInform Abstract in Full Text.
Highly Enantioselective Organocatalytic Hydroxyalkylation of Indoles with Ethyl Trifluoropyruvate.
Authors: Toeroek Bela , Abid Mohammed , London Gabor , Esquibel Joseph , Toeroek Marianna , Mhadgut Shilpa C. , Yan Ping , Prakash G. K. Surya 
Published: August 2005

AbstractFor Abstract see ChemInform Abstract in Full Text.
Synthesis and Evaluation of N‐(5‐Methyl‐3‐oxo‐1,2‐diphenyl‐2,3‐dihydro‐1H‐pyrazol‐4‐yl) ‐N′‐phenylureas as Cholecystokinin Antagonists.
Authors: Lattmann Eric , Sattayasai Jintana , Boonprakob Yodchai , Lattmann Pornthip , Singh Harjit 
Published: August 2005

AbstractFor Abstract see ChemInform Abstract in Full Text.
An Efficient Synthesis of 2‐Oxazolidinones by Palladium‐Catalyzed Oxidative Carbonylation of β‐Amino Alcohols and 2‐Aminophenol under Mild Conditions.
Authors: Li Fu‐Wei , Peng Xin‐Gao , Xia Chun‐Gu , Hu Bin 
Published: August 2005

AbstractFor Abstract see ChemInform Abstract in Full Text.
Lactams as Prostanoid Receptor Ligands. Part 4. 2‐Piperidones as Selective EP4 Receptor Agonists.
Authors: Elworthy Todd R. , Brill Emma R. , Caires Christopher C. , Kim Woongki , Lach Leang K. , Tracy Jahari Laurant , Chiou San‐San 
Published: August 2005

AbstractFor Abstract see ChemInform Abstract in Full Text.
A Green Approach to the Synthesis of 2,3‐Dihydropyrimidin‐2(1H)‐ones by Uronium Hydrogensulfate under Solvent‐Free Conditions.
Authors: Salehi Peyman , Dabiri Minoo , Zolfigol Mohammad Ali , Baghbanzadeh Mostafa 
Published: August 2005

AbstractFor Abstract see ChemInform Abstract in Full Text.
One‐Pot Synthesis of Bis(dihydropyrimidinone‐4‐yl)benzene Using Boric Acid as a Catalyst.
Authors: Tu Shu‐Jiang , Zhu Xiao‐Tong , Fang Fang , Zhang Xiao‐Jing , Zhu Song‐Lei , Li Tuan‐Jie , Shi Da‐Qing , Wang Xiang‐Shan , Jl Shun‐Jun 
Published: August 2005

AbstractFor Abstract see ChemInform Abstract in Full Text.
A New Synthesis of 2‐Substituted 4H‐3,1‐Benzoxazin‐4‐ones by Cyanuric Chloride Cyclodehydration of N‐Benzoyl‐ and N‐Acylanthranilic Acids.
Authors: Khajavi Mohammad S. , Shariat Seyed M. 
Published: August 2005

AbstractFor Abstract see ChemInform Abstract in Full Text.
Discovery of Novel Conformationally Constrained Tropane‐Based Biaryl and Arylacetylene Ligands as Potent and Selective Norepinephrine Transporter Inhibitors and Potential Antidepressants.
Authors: Zhou Jia , Klaess Thomas , Johnson Kenneth M. , Giberson Kelly M. , Kozikowski Alan P. 
Published: August 2005

AbstractFor Abstract see ChemInform Abstract in Full Text.
Total Synthesis and Antioxidative Activity of Magnolamide from Magnolia coco.
Authors: Chiou Wen‐Fei , Shen Chien‐Chang , Yu Hsi‐Jung , Chiang Chang‐Han , Chen Ching‐Chuan , Chang Wenyi , Don Ming‐Jaw 
Published: August 2005

AbstractFor Abstract see ChemInform Abstract in Full Text.
First Observation of Quamtum Splitting Behavior in Nanocrystalline SrAl12O19:Pr, Mg Phosphor.
Authors: Loureiro Sergio M. , Setlur Anant , Heward William , Taylor Seth T. , Comanzo Holly , Manoharan Mohan , Srivastava Alok , Schmidt Paul , Happek Uwe 
Published: August 2005

AbstractFor Abstract see ChemInform Abstract in Full Text.
Ferrimagnetic Nanogranular Co3O4 Through Solvothermal Decomposition of Colloidally Dispersed Monolayers of α‐Cobalt Hydroxide.
Authors: Nethravathi C. , Sen Sonia , Ravishankar N. , Rajamathi Michael , Pietzonka Clemens , Harbrecht Bernd 
Published: August 2005

AbstractFor Abstract see ChemInform Abstract in Full Text.
Application of N‐Vinylimidoyl, N‐Arylimidoyl and Hydrazonyl Compounds in the Synthesis of N‐Heterocycles
Authors: Zielinski Wojciech , Kudelko Agnieszka , Mazik Monika , Czardybon Wojciech 
Published: August 2005

AbstractFor Abstract see ChemInform Abstract in Full Text.
Kinetik und Reaktionstechnik der Synthese ionischer Flüssigkeiten
Authors: Jess A. , Große Böwing A. , Wasserscheid P. 
Published: August 2005

AbstractIonische Flüssigkeiten (Ionic Liquids, ILs) sind neuartige Lösungsmittel mit vielfältigen Einsatzmöglichkeiten, z. B. in der Katalyse und in Trennprozessen. Bisher werden ILs vor allem in Laborbatch‐Reaktoren hergestellt. Die dadurch eingeschränkte Verfügbarkeit und der immer noch relativ hohe Preis stehen einer technischen Anwendung häufig noch entgegen. Eine Verbesserung der Herstellung durch ein möglichst kontinuierliches Verfahren ist daher wünschenswert. Im Beitrag werden die grundsätzlichen Syntheserouten, die Kinetik und die Reaktionstechnik der IL‐Synthese diskutiert, insbesondere im diskontinuierlichen Rührkessel und im Rohrreaktor. Dazu werden beispielhaft Untersuchungsergebnisse zur Synthese von 1‐Butyl‐3‐methylimidazoliumchlorid ([BMIM]Cl) und von 1‐Ethyl‐3‐methylimidazoliumethylsulfat ([EMIM][EtSO4]) herangezogen, da sich beide Synthesen bzgl. der Reaktionsgeschwindigkeit, des Phasenverhaltens und der Notwendigkeit einer sehr guten Wärmeabfuhr deutlich unterscheiden.
Elektrochemische Verfahren – Neuentwicklungen und Tendenzen
Authors: Hoormann D. , Pütter H. , Jörissen J. 
Published: August 2005

AbstractElektrochemische Verfahren sind für viele Großprodukte unverzichtbar, wie z. B. für Chlor und Natronlauge sowie für Aluminium und etliche andere Metalle. Die erfolgreiche Optimierung dieser Verfahren hat große wirtschaftliche Bedeutung, insbesondere unter dem Gesichtspunkt des Energieverbrauchs. Darüber hinaus soll gezeigt werden, dass elektrochemische Verfahren an einer Fülle von Innovationen beteiligt sind. Gasdiffusionselektroden kommen erstmals in industriellen Elektrolysen zum Einsatz und führen zu erheblichen Energieeinsparungen. Industriell erfolgreich sind auch neue Verfahren der organischen Elektrochemie, die einen wichtigen Beitrag zur Green Chemistry leisten. Neue Elektrodenmaterialien eröffnen interessante Anwendungsmöglichkeiten. In einer zukünftigen nachhaltigen Energieversorgung wird die Elektrochemie eine wesentliche Rolle spielen.
Klimaänderung und Klimaschutz
Authors: Zellner R. 
Published: August 2005

AbstractDie naturwissenschaftlichen Erkenntnisse über anthropogen induzierte Klimatrends sind seit nunmehr zwei Jahrzehnten auch Gegenstand der gesellschaftlichen Diskussion und des politischen Handlungsbedarfs. Während die Verringerung von Treibhausgasemissionen das wesentliche Ziel der Klimaschutzpolitik war und immer noch ist, hat sich langsam aber auch die Überzeugung durchgesetzt, dass die Anpassung an Klimawandel eine unumgängliche Bedingung ist, die Folgen auf Mensch und Ökosysteme zu verringern. Dies ist darin begründet, dass sowohl der Schutz vor dem derzeitigen Klima verbesserter Anpassung bedarf als auch weitere anthropogen bedingte Klimaveränderung trotz des Kyoto‐Protokolls praktisch nicht vermeidbar ist. Klimaänderung ist aber beherrschbar – soweit die Gesellschaft die Möglichkeit wahrnimmt, sich darauf einzustellen.