bluuebunny/crossref_metadata_2025_split huggingface dataset:
Radar and Profiler Observations of the Kinematic and Thermodynamic Structure of a Shallow Bore in a Low-Shear Environment
Authors: Knupp Kevin , Wingo Stephanie M. , Goudeau Barrett , Pangle Preston 
Published: January 2025

Abstract
Observations obtained from scanning radars, two profiling systems, surface, and radiosonde instruments are utilized to describe the weakening stages of a long-lived (>4 h), shallow bore that evolved within a low-shear environment on 23 August 2013 over northern Alabama. RHI scans from a scanning X-band radar provided details on the bore shape and surrounding mesoscale perturbations in airflow, while a Doppler lidar afforded high-resolution vertical motion profiles at a location 24 km away. During passage over both profiling sites, updrafts (∼2 m s−1) were sampled over the lowest several hundred meters AGL, and aerosol backscatter showed upward displacements of 300–400 m near the 1.2 km AGL level. The surface pressure rise of ∼0.3 hPa at multiple locations over the observational network corroborates the shallowness of both the bore and the surface-based inversion. Several other unique features were documented, including bore movement in the direction of the weak low-level flow; a gust front structure with a well-defined feeder flow trailing the bore gust front, both confined to the lowest 500 m AGL; the presence of waves preceding and following the bore disturbance, with a 12–21-min period within the 0.5–2.5-km layer above the bore at both profiler locations; and variations in the horizontal flow in the form of a weak jet near 1.4 km AGL, with winds in the jet aligned in the same direction as bore movement, and located more than 10 km ahead of the bore gust front.

Significance Statement
This study documents a shallow bore utilizing a suite of ground-based remote sensing instruments. A scanning X-band radar, important in this case, defined the shape and the horizontal/vertical extent of perturbation flows associated with the bore. The bore remained identifiable as a radar fine line for a period of around 4.5 h, despite evolving within a low-shear environment. One implication of this work is that weak/shallow bores may be more common than previously realized.
An Empirical Analysis of Macro-wide and Sectoral Responses to Brown Energy Price Shocks in EU Economies
Authors: Barci Giovanni , Maurin Laurent 
Published: January 2025

We build a Brown Energy Price Index (BEPI) for EU economies and sectors. The index is then incorporated in PVAR models to analyse the reaction to price shock, the impact on economic activity and the change in the energy mix. The panel dimension comes from the thirteen EU economies and it is declined across five economic sectors. At the macroeconomic level, a positive shock to BEPI triggers some substitution between brown and green energy. Since the substitution falls short of the needs, activity contracts; nonetheless, part of the energy substitution is maintained after the shock is absorbed. At the sector level, our results confirm the substitution effect and the adverse impact on activity. Moreover, the magnitude of the responses are shown to be correlated with the sectors brown energy intensity of production. JEL Codes: C30, E30, Q40
Systemic bupropion treatment reduces long-access cocaine self-administration in male and female rats
Authors: Templeton-Jager Taylor J , Diarra Siga , Kelley Leslie K , Gilpin Nicholas W 
Published: January 2025

Background: More than 1 million people in the United States meet the criteria for cocaine use disorder (CUD), and over 19,000 people died from cocaine-related overdoses in 2020, but there are currently no FDA-approved medications for the treatment of CUD. Bupropion is an antidepressant currently prescribed to treat depression and nicotine addiction that acts by inhibiting norepinephrine and dopamine transporters. Methods: In this study, we tested the effect of several doses of systemic bupropion on cocaine self-administration in male and female Wistar rats. In our first experiment, rats self-administered cocaine solution intravenously and were pretreated with systemic bupropion before self-administration sessions. In our second experiment, rats were pre-treated with bupropion before completing tests of locomotor activity and anxiety-like behavior. Results: We found that high doses of systemically administered bupropion (60 mg/kg) attenuated cocaine self-administration in male and female rats during extended-access (6 h) sessions. We also found that the highest dose (60 mg/kg) of systemic bupropion was more efficacious in females relative to males during the first hour of operant sessions. Systemic bupropion did not alter locomotor activity, inactive lever presses, or food intake. The Estrous cycle did not influence cocaine intake with or without bupropion. Conclusion: Our finding that bupropion attenuates cocaine self-administration suggests that bupropion may have promise for reducing cocaine use in humans.
Midterm to Long-term Follow-up After Limited Saucerization of a Discoid Lateral Meniscus: Radiological and Functional Outcomes With Age-Dependent Variations
Authors: Aksoy Taha , Goymen Ibrahim Mehmet , Huri Gazi , Turhan Egemen , Kocher Mininder S. , Atay Ozgur Ahmet 
Published: January 2025

Background: A discoid lateral meniscus (DLM) is the most common meniscus variant and is commonly treated with arthroscopic saucerization. There are mixed data regarding long-term results after surgery, especially in terms of radiological parameters. Purpose/Hypothesis: The aim was to evaluate the functional and radiological results of patients who underwent arthroscopic saucerization for a symptomatic DLM. It was hypothesized that successful outcomes can be achieved by avoiding excessive resection while reshaping only to an extent that prevents mechanical symptoms. Study Design: Case series; Level of evidence, 4. Methods: This study retrospectively analyzed pediatric and adult patients who had a symptomatic discoid meniscus between 2000 and 2018, who underwent arthroscopic saucerization with at least 10 mm of peripheral length, and who had at least 5 years of follow-up. Radiological parameters were measured on both preoperative and follow-up radiographs. Patient-reported outcome measure scores were recorded at follow-up. Results: The study included 57 knees of 53 patients (mean age, 27.6 years [range, 6-65 years]). The mean follow-up duration was 12.1 years (range, 5.0-23.1 years). There were 31 knees in the pediatric group and 26 knees in the adult group. No significant difference was found between the groups or between preoperative and follow-up values for the femorotibial angle ( P > .05). When the preoperative and follow-up Kellgren-Lawrence grades were compared, no change was observed in the pediatric group ( P = .125), while grades were shown to progress in the adult group ( P < .001). The mean Lysholm score was 94.61 ± 7.61 and 84.23 ± 14.90 for the pediatric and adult groups, respectively ( P = .001). Overall, 2 patients underwent arthroscopic surgery because of a symptomatic recurrence of symptoms, and 2 patients underwent arthroplasty because of osteoarthritis. The 10-year survival rate was 90.6%. Conclusion: Limited saucerization of a DLM helped to preserve coronal-plane knee joint alignment. Functional and radiological results were superior in the pediatric patients. Even when alignment was more varus in older patients, preoperative and follow-up femorotibial angles were not statistically significant. This outcome may be used to guide treatment in appropriately selected cases.
Job accommodations: Knowing what, when, and how to request
Authors: Trierweiler Robert 
Published: January 2025

Background This paper summarizes a presentation made at the Technical Assistance Center for Quality Employment at the 2024 National Symposium on Quality Employment. Objective The objective of this paper is to highlight the need for education of workers with disabilities on the process for requesting job accommodations. Methods and Results The process of employment accommodations is reviewed in detail from the need to request a job accommodation to filing a complaint with the Equal Opportunity Employment Commission. Conclusion Employees with disabilities, particularly young adults, are often unaware of the job accommodations process.
Outpatient parenteral antibiotic therapy with elastomeric pumps, what is the flowrate accuracy?
Authors: Muller Arthur , Rétory Yann , Négrier Laura , Lemarié Benoit , Pfeifer Anne , Schmidt Alexandra , Dupont Christian , Virbel-Fleischman Clara 
Published: January 2025

Background: Outpatient Parenteral Antibiotic Therapy (OPAT) services have expanded throughout the world thanks to elastomeric pumps (EP). Their flowrate is known to vary by ±15%. Treatment effectiveness and the organization of care at home may be impacted, especially with piperacillin/tazobactam infusion (TAZ). An in vitro study was conducted, following the guidelines of EP and drug manufacturers, to assess the impact of three parameters on the accuracy of the infusion flowrate: composition, volume, and temperature of the infused solution. Methods: A test bench was created to evaluate the accuracy of flowrate infusion when changing one parameter at a time (addition of TAZ in the infused solution, minimal filling volume and flow regulator at ambient temperature) compared to the standard conditions provided by the manufacturer. Two types of EP were used and connected to a weighing scale. Instantaneous and average mass flowrates over the total infusion time were determined from the reservoir mass loss. These values  were compared with the nominal flowrates announced by the manufacturers to evaluate the performance of EP under the different conditions. The time the flowrate was within the expected ±15% around the nominal flowrate was calculated as the time in range (TIR). Results: Deviations of the measured mean flowrate from the nominal flowrate range from −37% to 18% depending on the condition. TIR went from 0% to 80% of the total infusion duration. The test bench showed a reliability of more than 96%. Conclusions: The test bench highlights differences in performance. These results raise several questions about the sensitivity of EPs for TAZ infusion in OPAT, the norm’s requirements and the need to prescribe a medical device whose limits are well known, as well as therapeutic education or the course of care for treatment administration.
Antondine Injection-Associated Fixed Drug Eruption: A Case Report
Authors: Yang Yan , Li Peng-Fei , Ma Qiang , Wang Xiao-Na , Chen Qing , Ma Ling-Yun , Tang Hao , Wang Zhen 
Published: January 2025

Background: Fixed drug eruption (FDE) is a drug hypersensitivity reaction caused by antibiotics and non-steroidal anti-inflammatory drugs primarily. Antondine injection is a drug used to reduce fever, mainly composed of aminopyrine, antipyrine and barbiturate, and its adverse reactions include anaphylactic shock, epidermolysis, rash, agranulocytosis, etc. FDE caused by Antondine injection is an uncommon phenomenon, and the drug eruption caused by these ingredients has been reported in the current case report. However, the fatal severe fixed drug eruption caused by it has not been reported. Here, we report a case of severe PDE after treatment with Antondine, highlighting it’s necessary to avoid these medications with this ingredient when using antipyretic medications.
Remote assessment of exercise capacity in adults with chronic respiratory disease: Safety, reliability and acceptability
Authors: Cox Narelle S , Dal Corso Simone , Burge Angela T , Bondarenko Janet , Perryman Jaycie , Holland Anne E 
Published: January 2025

Objectives To assess the safety, reliability and acceptability of the modified incremental step test (MIST) supervised remotely via videoconferencing in adults with chronic respiratory disease. Methods Adults with chronic respiratory disease undertaking pulmonary rehabilitation were invited to undertake the MIST under two testing conditions: in-person supervision and remote supervision via video-conferencing. Test order was randomised. Results 38 participants ( n = 18 Female; mean (SD) age 68 (10) years; 56% chronic obstructive pulmonary disease) undertook two MIST evaluations. There was excellent agreement between tests for total step count (ICC2,1 0.93, 95%CI 0.86 to 0.96), despite higher counts with in-person supervision (MD 12 steps, 95%CI 1 to 24). There was very good agreement, and no difference between tests, for nadir oxygen saturation (ICC2,1 0.797, 95%CI 0.643 to 0.889) and peak heart rate (ICC2,1 0.782, 95%CI 0.620 to 0.880). Participant satisfaction with telehealth was high, and confidence was not different between testing conditions. There were no adverse events and remote testing was acceptable to participants. Discussion In this single centre cohort study MIST supervised remotely via video-conferencing was safe, reliable and acceptable to people with chronic respiratory disease.
Long-Term Intracranial Progression-Free Survival in Lung Cancer Brain Metastases Extended Beyond 50 Months with Gubenxiaoyi Formula (GBXY): A Groundbreaking Case Study
Authors: Yang Zhengzheng , Li Haiming , Chen Lei , Li Shujiao , Chen Dong , Lu Taicheng , Ding Tongjing , Han Ruiyang , Cheng Peiyu , Wang Xiaomin 
Published: January 2025

Background: The prevalence of brain metastases (BM) in lung cancer patients is notably high and is associated with poor prognoses. The efficacy of standard treatment regimens in improving intracranial progression-free survival (IPFS) for lung cancer BM is markedly limited. While traditional Chinese medicine (TCM) has been effective in enhancing the quality of life and prognosis of lung cancer patients, its efficacy in treating BM remains unreported. Case presentation Here, we present a case of a middle-aged female with lung cancer BM, whose condition was assessed as progressive post-standard treatment including two local surgeries (both involving resection of cerebellar space-occupying lesions), stereotactic radiotherapy, chemotherapy and EGFR-TKIs. Subsequently, she underwent treatment with the traditional Chinese herbal formula gubenxiaoyi (GBXY). The patient was treated with GBXY for a total duration of 55 months. After treatment, a significant reduction of about 50% in intracranial lesions was observed, accompanied by an extension of both Intracranial Progression-Free Survival (IPFS) and Cognitive Deterioration-Free Survival (CDFS) exceeding 50 months. Conclusion These results demonstrate that in patients with lung cancer brain metastases (BM) unresponsive to standard treatments, GBXY not only has the potential to effectively prolong IPFS and decelerate cognitive decline, but may also contribute to a reduction in intracranial tumor burden. This suggests that GBXY could be a promising therapeutic option that warrants further investigation.
Orthopaedic Sports Injuries in an Aging Population: Current Trends and Future Projections
Authors: Zaifman Jay M. , Megalla Martinus , Grace Zachary , Imam Nareena , Koerner John D. , Kohan Eitan , Alberta Francis G. 
Published: January 2025

Background The elderly US population is growing quickly and staying active longer. However, there is limited information on sports-related injuries in older adults. Hypotheses (1) National estimate and incidence of sports-related orthopaedic injuries in the US elderly population have increased over the last 10 years, (2) types and causes of sports-related injuries in the elderly have changed, and (3) elderly sports-related injuries will increase more than the number of treating physicians by 2040. Study Design Descriptive epidemiology study. Level of Evidence Level 4. Methods: The National Electronic Injury Surveillance System database was used to identify all patients aged ≥65 years with sports-related orthopaedic injuries in US emergency departments from 2012 to 2021. Surgeon and physician estimates were calculated using the Physician Compare database. Population data were obtained from US Census estimates and used to calculate annual incidence rates of injuries and to project total injuries through 2040. Injury characteristics were analyzed using Wilcoxon Rank-Sum tests and Chi-square or Fisher exact tests. Results An estimated 444,078 sports-related orthopaedic injuries occurred in the elderly from 2012 to 2021. There were significant increases in injuries (from 32,573 in 2012 to 50,909 in 2021; P < 0.01) and in the national incidence of injuries (from 78 per 100,000 in 2012 to 91 per 100,000 in 2021; P = 0.01). The number of sports-related injuries in the elderly is projected to reach 111,245 by 2040, an increase of 119% from 2021. The number of orthopaedic surgeons and sports medicine physicians is projected to increase by only 19.7% over the same timeperiod. Conclusion: Sports-related orthopaedic injuries in the elderly are increasing in both number and incidence. Clinical Relevance Orthopaedic surgeons and other practitioners should be prepared to treat an increasing number of active elderly patients.
Evaluating the Corrected Femoroepiphyseal Acetabular Roof Index in Patients With Borderline Dysplasia Undergoing Periacetabular Osteotomy or Hip Arthroscopy
Authors: Dimitriou Dimitris , Neopoulos Georgios , Jud Lukas , Zingg Patrick O. 
Published: January 2025

Background: Identifying hip instability in symptomatic patients with borderline dysplasia of the hip (BDH) is of paramount importance, as it can influence both surgical decision-making and surgical outcomes. The femoroepiphyseal acetabular roof (FEAR) index is strongly affected by the hip adduction/abduction angle during the pelvic radiograph, which has not yet been considered in the recommended threshold values. Purpose: To compare the corrected FEAR index in symptomatic patients with BDH treated with pelvic periacetabular osteotomy (PAO) or hip arthroscopy. Study Design: Cohort study; Level of evidence, 3. Methods: Patients with symptomatic hips and radiographical BDH were categorized into 2 cohorts. The first cohort included patients treated with PAO (n = 42) and the second cohort consisted of patients treated with hip arthroscopy due to symptomatic femoroacetabular impingement (n = 50). All patients presented with good patient-reported outcomes at the final follow-up. The FEAR index was measured on the pelvic radiograph at the initial hip adduction/abduction angle (uncorrected FEAR index) and after correcting the hip abduction angle to 0° (corrected FEAR index). Negative values of the FEAR index represent a lateral closing angle, whereas positive values represent a lateral opening angle. As for the hip adduction/abduction angle, negative values represent adduction, whereas positive values represent abduction. Results: The corrected FEAR index varied significantly from the uncorrected FEAR index in both groups with a mean difference of 6°± 4° in patients treated with PAO and 5°± 5° in patients treated with hip arthroscopy. The corrected FEAR index in patients with BDH treated with hip arthroscopy (−11°± 8°) was significantly lower ( P < .001) compared with the patients with BDH treated with PAO (−7°± 7°) (Table 1). The optimal threshold for the corrected FEAR index was −13° (odds ratio, 7.8 [95% CI, 2.6-23.1]; P < .001), which yielded a sensitivity of 85% and a specificity of 52%, distinguishing the 2 surgical cohorts. Conclusion: The corrected FEAR index might vary significantly from the uncorrected FEAR index, which is highly dependent on the hip adduction/abduction angle during the pelvic radiograph. Symptomatic patients with BDH treated with PAO exhibit a corrected FEAR index of ≥–13° compared with those with BDH treated with hip arthroscopy for impingement symptomatology.
CircUCK2(2,3) promotes cancer progression and enhances synergistic cytotoxicity of lenvatinib with EGFR inhibitors via activating CNIH4–TGFα–EGFR signaling
Authors: Wei Xindong , Si Anfeng , Zhao Shuai , Fu Yi , Li Jilei , Aishanjiang Kedeerya , Ma Yujie , Yu Chang , Yu Bo , Cui Chunhong , Wang Hui , Kong Xianming , Li Shibo , Kong Xiaoni , Tong Ying , Wu Hailong 
Published: January 2025

Abstract

Background
Circular (circ)RNAs have emerged as crucial contributors to cancer progression. Nonetheless, the expression regulation, biological functions, and underlying mechanisms of circRNAs in mediating hepatocellular carcinoma (HCC) progression remain insufficiently elucidated.

Methods
We identified circUCK2(2,3) through circRNA sequencing, RT–PCR, and Sanger sequencing. CircUCK2(2,3) levels were measured in two independent HCC cohorts using quantitative real-time PCR (qRT–PCR). We explored the functions of circUCK2(2,3) using gain- and loss-of-function assays. Techniques such as RNA-sequencing, RNA immunoprecipitation (RIP), polysome fractionation, RNA pulldown, dual luciferase reporter assay, inhibitors of EGFR downstream signaling, CRISPR–Cas9, and medium transfer assays were employed to investigate the regulatory mechanisms and the protumoral activities of circUCK2(2,3). Additionally, in vitro cytotoxic assays and patient-derived xenograft (PDX) models assessed the effects of circUCK2(2,3) on the cytotoxic synergy of lenvatinib and EGFR inhibitors.

Results

CircUCK2(2,3) is upregulated in HCC tissues and serves as an independent risk factor for poor recurrence-free survival. The expression of circUCK2(2,3) is independent on its host gene, UCK2, but is regulated by its upstream promoter and flanking inverted complementary sequences. Functionally, circUCK2(2,3) enhances HCC proliferation, migration, and invasion, both in vitro and in vivo. Mechanistically, by sponging miR-149-5p, circUCK2(2,3) increases CNIH4 levels, which in turn amplifies TGFα secretion, resulting in the activation of EGFR and downstream pAKT and pERK signaling pathways. Moreover, circUCK2(2,3) overexpression sensitizes HCC cells to EGFR inhibitors, and increases the synergistic cytotoxicity of combined lenvatinib and EGFR inhibitor treatment.

Conclusions

CircUCK2(2,3) regulates a novel oncogenic pathway, miR-149-5p–CNIH4–TGFα–EGFR, in HCC, presenting a viable therapeutic target and biomarker for the precision treatment of HCC.

Graphical Abstract