bluuebunny/crossref_metadata_2025_split huggingface dataset:
Delineating family needs in the transition from hospital to home for children with medical complexity: part 2, a phenomenological study
Authors: van de Riet L. , Alsem M. W. , Beijneveld R. S. I. , van Woensel J. B. M. , van Karnebeek C. D. 
Published: December 2023

Abstract
Background
A systematic literature review on the transition from hospital-to-home (H2H) of families with a child with medical complexity (CMC), resulted in nine overarching themes. These demonstrated common needs and experiences despite the widely differing CMC diagnoses and family characteristics. However, none of the reported studies was conducted in the Netherlands, which hampers the creation of a tailored H2H care pathway, deemed essential for our recently established Transitional Care Unit in the Netherlands: the ‘Jeroen Pit Huis’. Therefore, the aim of this study was to gain a deeper understanding of the needs and experiences of Dutch CMC parents on H2H transition and integrate these insights with the literature review into an evidence-based H2H care pathway for CMC and their families.

Methods
A descriptive phenomenological approach was applied. Heterogeneous purposeful sampling methods were used to recruit participants according to the following criteria: parents of CMC from various regions in the Netherlands, who spoke Dutch fluently and who had been discharged home from a tertiary hospital within the previous five years. Semi-structured, open-ended interviews were conducted via video call by two researchers, who transcribed the audio recordings verbatim. Thematic analysis methods were used to identify emerging themes from the individual transcripts, involving a third and fourth researcher to reach consensus.

Results
Between March and August 2021, 14 mothers and 7 fathers participated in 14 interviews. They elaborated on the H2H transition of 14 CMC with a wide range of underlying diseases: 7 male, 7 female, aged 6 months to 10 years. Eight overarching themes, consistent with the results of the systematic review, represent CMC parental needs and experiences during the H2H process in the Netherlands: (1) autonomy, (2) division of tasks and roles, (3) family emotions, (4) impact on family life, (5) communication, (6) coordination of care, (7) support system and (8) adaptation.

Conclusions
The H2H needs and experiences reported by the CMC families in this study align with the results of our systematic review. The H2H transition process is not linear but continuous, and should extend beyond the specific medical needs of the CMC to holistic care for the family as a whole. The overarching care needs and experiences, expressed by all CMC families, regardless of underlying symptoms and diagnoses, inform the H2H care pathway and its future evaluation. Our studies highlight the necessity to focus on the family needs rather than on the specific illness of the child, as well as the value of our interdisciplinary care team partnering with parents in the ‘Jeroen Pit Huis’ towards a safe and sustainable transition home.
Event-related potential (ERP) evidence for visual processing differences in children and adults with cystinosis (CTNS gene mutations)
Authors: Horsthuis Douwe J. , Molholm Sophie , Foxe John J. , Francisco Ana A. 
Published: December 2023

Abstract
Background
Cystinosis, a rare lysosomal storage disease caused by mutations in the CTNS gene, is characterized by cystine crystallization and accumulation within multiple tissues, including kidney and brain. Its impact on neural function appears mild relative to its effects on other organs during early disease, but since therapeutic advances have led to substantially increased life expectancy, neurological implications are of increasing interest, necessitating deeper understanding of the impact of cystinosis on neurocognitive function. Behavioral difficulties have been reported in cystinosis in the visual domain. Very little is known, however, about how the brains of people living with cystinosis process visual information. This is especially interesting given that cystine accumulation in the cornea and posterior ocular structures is a hallmark of cystinosis.

Methods
Here, high-density scalp electrophysiology was recorded to visual stimuli (during a Go/No-Go task) to investigate visual processing in individuals with cystinosis, compared to age-matched controls. Analyses focused on early stages of cortical visual processing.

Results
The groups differed in their initial cortical response, with individuals with cystinosis exhibiting a significantly larger visual evoked potential (VEP) in the 130–150 ms time window. The groups also differed in the associations between neural responses and verbal abilities: While controls with higher IQ scores presented larger neural responses, that relationship was not observed in cystinosis.

Conclusions
The enlarged VEP in cystinosis could be the result of cortical hyperexcitability and/or differences in attentional engagement and explain, at least partially, the visual and visual-spatial difficulties described in this population.
Multi-user communications for line-of-sight large intelligent surface systems
Authors: Chen Jiayi 
Published: December 2023

AbstractIn this paper, we propose a new interference-suppression beamformer design and a Direction-of-Arrival (DoA) estimation method for Line-of-Sight (LoS) multi-user communication systems with circular Large Intelligent Surfaces (LISs). This symmetrical circular-shaped LIS allows signals defined on it to be formed by combining Fourier and Bessel series. The Fourier harmonics are orthogonal along the rotational direction and the Bessel functions constituting the Bessel series are orthogonal along the radial direction. Synthesizing basis functions from these two series results in the proposed interference-suppression beamformer, with their coefficients designed to cancel inter-user interference. Also by exploiting signal structure of a circular LIS communicating with Mobile Stations (MSs), we devise a DoA estimation method to obtain directional information of incoming signals. Under LoS channel, the DoA corresponds to elevation and Azimuth angles of MSs relative to the LIS. This method is numerically demonstrated to have promising performance with high-frequency carriers.
Kirschner wire reconstruction of medial and lateral column periosteal hinge in the treatment of multidirectionally unstable supracondylar fracture of the humerus in children
Authors: Ma Hai-Long , Sun Xi-Wei , Liu Fang , Hua Zhong Tuo , Sun Jun , Zhang Si-Cheng 
Published: December 2023

Abstract
Aim and objective
To compare the clinical effect of reconstruction of internal and lateral column periosteal hinge-assisted treatment with Kirschner wire and internal fixation with Kirschner wire in the treatment of multidirectional unstable supracondylar fractures of humerus in children.

Methods
A retrospective cohort study was conducted to analyze the clinical data of 48 patients (31 male, 17 female; mean age: 6.7 ± 2.4 years old) with multidirectionally unstable supracondylar fractures of the humerus treated in our Hospital from August 2020 to August 2022. Twenty-five cases were treated with Kirschner wire reconstruction of the internal and lateral column periosteal hinge assisted by closed reduction and Kirschner wire internal fixation (study group). Twenty-three cases were treated with closed reduction and Kirschner wire internal fixation (control group). The operation time, intraoperative fluoroscopy times, percentage of patients who underwent open reduction after failure of closed reduction, fracture healing time, Baumann angle (BA), shaft-condylar angle (SCA), range of motion (ROM), and Flynn score of elbow at the last follow-up were compared between two groups. Complications such as infection and irritation of Kirschner wire tail were observed in two groups 2 months after the operation.

Results
All patients were followed up for 10–22 months ([13.85 ± 2.89] months). The average operation time of the control group was 82.1 min, which was significantly longer than that of the study group 32.3 min (P < 0.05). The number of intraoperative fluoroscopy (29.4 ± 9.2) in the control group was significantly higher than that in the study group (15.2 ± 6.3) (P < 0.05). The incision rate of the control group was 17% while that of the study group was 0 (P < 0.05). According to Flynn score, the excellent and good rate of the elbow joint in the control group was 86.9% (20/23). The excellent and good rate of the elbow joint in the study group was 92.0% (23/25) (P > 0.05). There was no significant difference in fracture healing time, BA, SCA, and ROM between the two groups (P > 0.05). No infection or Kirschner wire tail irritation occurred in the two groups during the 2-month follow-up.

Conclusion
Reconstruction of internal and lateral periosteal hinges with Kirscher wire has similar effects to closed reduction and Kirschner wire fixation in the treatment of multidirectionally unstable supracondylar fractures of the humerus in children, but it can shorten the operation time and reduce intraoperative fluoroscopy times and incision rate.
SAFIR-I: first NEMA NU 4-2008-based performance characterization
Authors: Bebié Pascal , Lustermann Werner , Debus Jan , Ritzer Christian , Dissertori Günther , Weber Bruno 
Published: December 2023

AbstractBackgroundSmall Animal Fast Insert for MRI detector I (SAFIR-I) is a novel Positron Emission Tomography insert for a$$7\,\hbox {T}$$7TBruker BioSpec 70/30 Ultra Shield Refrigerated Magnetic Resonance Imaging (MRI) system. It facilitates truly simultaneous quantitative imaging in mice and rats at injected activities as high as$$500\,\hbox {MBq}$$500MBq. Exploitation of the resulting high count rates enables quick image formation at few seconds per frame. In this investigation, key performance parameters of SAFIR-I have been determined according to the evaluations outlined in the National Electrical Manufacturers Association (NEMA) Standards Publication NU 4-2008 (NEMA-NU4) protocol.ResultsUsing an energy window of 391 to$$601\,\hbox {keV}$$601keVand a Coincidence Timing Window of$$500\,\hbox {ps}$$500ps, the following performance was observed: The average spatial resolution at$$5\,\hbox {mm}$$5mmradial offset (Full Width at Half Maximum) is$$2.54\,\hbox {mm}$$2.54mmwhen using Filtered Backprojection, 3D Reprojection reconstruction. For the mouse- and rat-like phantoms, the maximal Noise-Equivalent Count Rates (NECRs) are$$1368\,\hbox {kcps}$$1368kcpsat the highest tested average effective concentration of$$14.7\,\hbox {MBq}\,\hbox {cc}^{-1}$$14.7MBqcc-1, and$$713\,\hbox {kcps}$$713kcpsat the highest tested average effective concentration of$$1.72\,\hbox {MBq}\,\hbox {cc}^{-1}$$1.72MBqcc-1, respectively. The NECR peak is not yet reached for either of these cases. The peak sensitivity is$$1.46\,\%$$1.46%. The Image Quality phantom uniformity standard deviation is$$4.8\,\%$$4.8%. The Recovery Coefficient for the$$5\,\hbox {mm}$$5mmrod is$$(1.08 \pm 0.10)$$(1.08±0.10). The Spill-Over Ratios are$$(0.22 \pm 0.03)$$(0.22±0.03)and$$(0.22 \pm 0.02)$$(0.22±0.02), for the water- and air-filled cylinder, respectively. An accuracy of$$4.3\,\%$$4.3%was achieved for the quantitative calibration of reconstructed voxel values.ConclusionsThe measured performance parameters indicate that the various design goals have been achieved. SAFIR-I offers excellent performance, especially at the high activities it was designed for. This facilitates planned experiments with fast tracer kinetics in small animals. Ways to potentially improve performance can still be explored. Simultaneously, further performance gains can be expected for a forthcoming insert featuring 2.7 times longer axial coverage named Small Animal Fast Insert for MRI detector II (SAFIR-II).
Development of a composite hydrogel incorporating anti-inflammatory and osteoinductive nanoparticles for effective bone regeneration
Authors: Byun Hayeon , Jang Gyu Nam , Jeong Hyewoo , Lee Jinkyu , Huh Seung Jae , Lee Sangmin , Kim Eunhyung , Shin Heungsoo 
Published: December 2023

Abstract

Background
Bone tissue regeneration is regulated by complex events, including inflammation, osteoinduction, and remodeling. Therefore, to induce the complete restoration of defective bone tissue, biomaterials with the ability to regulate the collective bone regenerative system are beneficial. Although some studies conclude that reducing reactive oxygen species created a favorable environment for bone regeneration by controlling inflammation, biomaterials that can simultaneously promote osteogenesis and regulate inflammation have not been developed. Herein, we describe the development of a multi-functional nanoparticle and its hydrogel composite with osteoinductive, anti-inflammatory, and osteoclast-maturation regulatory functions for enhanced bone regeneration.

Methods

Tannic acid–mineral nanoparticles (TMP) were prepared by self-assembly of tannic acid in an ion-rich simulated body fluid containing Ca
2+
and PO
4
3-
. Particles with a diameter of 443 ± 91 nm were selected for their stable spherical morphology and minimal tendency to aggregate. The particles were homogeneously embedded within a gelatin-based cryogel (TMP/Gel) to be used in further experiments. The osteoinductive properties, anti-inflammatory and osteoclast-maturation regulatory functions in vitro were tested by culturing corresponding cells on either TMP/Gel or a gelatin-based cryogel without the particles (Gel). For in vivo analyses, a murine calvarial defect model was used. Statistical analyses were carried out using a Graphpad Prism 7 software (San Diego, CA, USA) to perform one-way analysis of variance ANOVA with Tukey’s honest significant difference test and a Student’s
t
-test (for two variables) (
P
< 0.05).

Results
Excellent biocompatibility and radical scavenging abilities were exhibited by the TMP/Gel. The expression of osteogenic mRNA is significantly increased in human adipose-derived stem cells seeded on the TMP/Gel compared to those without the particles. Furthermore, RAW264.7 cells seeded on the TMP/Gel displayed significantly lower-than-normal levels of pro-inflammatory and osteoclastogenic genes. Finally, the in vivo results indicated that, compared with the cryogel with no anti-inflammatory effect, the TMP/Gel significantly enhanced both the quality and quantity of newly formed bone, demonstrating the importance of combining anti-inflammation with osteoinduction.

Conclusion
Collectively, these findings suggest our nanoparticle-hydrogel composite could be an effective tool to regulate complex events within the bone healing process.

Graphical Abstract
Hypertension in Cardio-Oncology Clinic: an update on etiology, assessment, and management
Authors: Askarinejad Amir , Alizadehasl Azin , Jolfayi Amir Ghaffari , Adimi Sara 
Published: December 2023

AbstractHypertension is one of the most common comorbidity and the leading cause of cancer-related death in cancer patients. The prevalence of hypertension in cancer patients is much higher than that of the general population. In the older population of cancer patients, specific cancer treatments such as new tyrosine kinase inhibitors and Vascular endothelial growth factor inhibitor drugs give rise to hypertension in cancer patients; The aim of present study is to provide a detailed discussion etiologies of cancer treatment-induced hypertension and explore the most innovative diagnostic and management approaches. This review will address the optimal approach to hypertension treatment, covering treatment initiation thresholds, targets, and the selection of anti-hypertensive agents. The lack of evidence in recent guidelines for managing cardiovascular toxicities in cancer patients can create uncertainty in clinicians' therapeutic and clinical decisions. This review aims to enhance our understanding of hypertension etiology in cancer patients and provide a practical guide to current treatment approaches.
Three-Vessel Anastomosis for Direct Multiterritory Cerebral Revascularization: Case Series
Authors: Rennert Robert C. , Atai Nadia A. , Nguyen Vincent N. , Abedi Aidin , Sternbach Sarah , Chu Jason , Carey Joseph N. , Russin Jonathan J. 
Published: December 2023

BACKGROUND AND OBJECTIVE:
Cerebral revascularization of multiple territories traditionally requires multiple constructs, serial anastomoses, or a combination of direct and indirect approaches. A novel 3-vessel anastomosis technique allows for direct, simultaneous multiterritory cerebral revascularization using a single interposition graft. We herein present our experience with this approach.

METHODS:
Retrospective review of perioperative data and outcomes for patients undergoing multiterritory cerebral revascularization using a 3-vessel anastomosis from 2019 to 2023.

RESULTS:
Five patients met inclusion criteria (median age 53 years [range 12-73]). Three patients with complex middle cerebral artery aneurysms (1 ruptured) were treated with proximal ligation or partial/complete clip trapping and multiterritory external carotid artery-M2-M2 revascularization using a saphenous vein interposition graft. Two patients with moyamoya disease, prior strokes, and predominately bilateral anterior cerebral artery hypoperfusion were treated with proximal superficial temporal artery-A3-A3 revascularization using a radial artery or radial artery fascial flow-through free flap graft. No patients experienced significant surgery-related ischemia. Bypass patency was 100%. One patient had new strokes from vasospasm after subarachnoid hemorrhage. One patient required a revision surgery for subdural hematoma evacuation and radial artery fascial flow-through free flap debridement, without affecting bypass patency or neurologic outcome. On hospital discharge, median Glasgow Outcome Scale and modified Rankin Scale scores were 4 (range 3-5) and 2 (range 0-5), respectively. On follow-up, 1 patient died from medical complications of their presenting stroke; Glasgow Outcome Scale and modified Rankin Scale scores were otherwise stable or improved.

CONCLUSION:
The 3-vessel anastomosis technique can be considered for simultaneous revascularization of multiple intracranial territories.
Combined Transpetrosal Approach: 2-Dimensional Operative Video
Authors: Jiang Tingting , Charitos Dimitrios , Justo Jerold , Alcantara Tancredo , Grouls Michelle , De Battista Juan , Passeri Thibault , Froelich Sébastien 
Published: December 2023

INDICATIONS: CORRIDOR AND LIMITS OF EXPOSURE:
This approach is suitable for petroclival lesions medial to V cranial nerve that extend in both middle and posterior fossa. It provides multiple surgical corridors with minimal brain retraction.

ANATOMIC ESSENTIALS: NEED FOR PREOPERATIVE PLANNING AND ASSESSMENT:
Several critical neurovascular structures of the petrous bone are at risk during the approach. Meticulous reading of the preoperative images is fundamental. It is mandatory to perform a thin section computed tomography scan, an MRI, and, in case of petroclival meningiomas, a digital subtraction angiography.

ESSENTIAL STEPS OF THE PROCEDURE:
In the first illustrative case, we present our current “mini-combined petrosectomy” with minimal drilling of the labyrinth. Positioning, skin incision, and craniotomy are illustrated in the video. Once all the important neurovascular structures are identified, we perform the anterior and the posterior petrosectomy, with preservation of the endolymphatic sac. We continue with dura mater opening and tentorium cutting. After tumor removal, we can appreciate an unique view of ipsilateral and contralateral cranial nerves, as well as pituitary stalk and major arteries.

PITFALLS/AVOIDANCE OF COMPLICATIONS:
To avoid injuries to the main neurovascular structures, neuronavigation, neuromonitoring, and Doppler can be useful.

VARIANTS AND INDICATIONS FOR THEIR USE:
The second illustrative case shows an extension of the combined petrosectomy to the anterior fossa, this made possible to perform a transsylvian approach for this giant sphenopetroclival meningioma. The patients consented to the procedure and to the publication of his/her images. Appropriate consent was obtained for the publication of the cadaveric images.
H «κουκλοποιία» και το κουκλοθέατρο σαν εργαλείο στην εκπαίδευση και
τη ψυχοθεραπεία
Authors: Νταϊφά Μαρίζα 
Published: December 2023

Το άρθρο παρουσιάζει τα οφέλη της κουκλοποιίας και κατά
πόσο μπορεί ο ενήλικας, με εργαλείο το κουκλοθέατρο, να βοηθήσει στην επίλυση ή στην
ανακούφιση κάποιων προβλημάτων των παιδιών, που μπορεί να προκύψουν είτε από λόγους
υγείας, είτε από μαθησιακές δυσκολίες.
design of an innovative system for the detoxification of pharmaceutical wastewater from pharmaceutical facilities.
Authors: LOIZIDOU MARIA , Giouni Eleni Alexia , Kyriazi Maria 
Published: December 2023

The concentration of Active Pharmaceutical Ingredients (APIs) in wastewater is directly affected by the increasing worldwide use of pharmaceuticals. The release of the wastewater may contaminate the surface water and marine life. Conventional wastewater treatment plants are unable to remove completely all APIs. The most frequently used methods are conventional activated sludge system (CAS) and membrane biological reactors (MBR), based on studies the removal percentage of APIs was lower than 10% in some compounds. Catalytic hydrogenation is a highly effective water treatment process that offers superior selectivity and reactivity compared to traditional methods, without the use of any chemicals. There is no need for additional wastewater treatment to remove any toxic byproducts that may be produced, making the process cost-effective and efficient. The catalytic reactions of hydrogenation are also rapid reactions with short residence times and smaller reactors, reducing both the operations and installation costs. The pilot will operate under room temperature and pressure conditions. This pilot will fully operate with renewable energy-solar energy (RES). The main components of the developed pilot system are a mixing tank, a filtration system, a water electrolysis unit operating with RES and a catalytic reactor where the concentrated stream from filtration system will be treated. In this reactor, the pharmaceutical compounds in the presence of a catalyst will be hydrogenated and converted to non-critical organic matter.
RETÓRICA, ARGUMENTACIÓN E INTELIGIBILIDAD DEL DERECHO: UNA PROPUESTA DE ABORDAJE DE LA PRAXIS ARGUMENTATIVA JUDICIAL PARTIR DE LOS APORTES DE PILAR ZAMBRANO.
Authors: De Rosa Eliana , De Rosa Eliana 
Published: December 2023

El presente trabajo se propone explorar y analizar las implicancias del reconocimiento de una dimensión discursiva en el fenómeno jurídico como consecuencia del auge del paradigma de la argumentación que ha impregnado las prácticas jurídicas en la actualidad. En particular, me focalizaré sobre el modo en que se complejiza tanto la praxis adjudicativa judicial a partir de la ampliación de marcos de referencia desde los que se opera como implicancia de las exigencias de contralor de constitucionalidad y convencionalidad. Esta modificación en las prácticas ha facilitado un aumento significativo de la discrecionalidad en las distintas instancias del proceso adjudicativo con la consecuente carga de justificar (argumentar) el modo en que se desenvuelve el razonamiento jurídico en general y judicial en particular. Procuraré demostrar cómo esta problematización de las prácticas jurídicas se materializa en un discurso que conlleva a su vez un ejercicio retórico a los fines de su comunicabilidad, que puede teñir de indeterminación la praxis jurídica tornándola ininteligible. Finalmente argüiré que las complejidades señaladas son susceptibles de superación a partir de la teoría de la inteligibilidad propuesta por la profesora de la Universidad de Navarra, Pilar Zambrano.