bluuebunny/crossref_metadata_2025_split huggingface dataset:
Representing variability in a family of MRI scanners
Authors: Jaring M. , Krikhaar R. L. , Bosch J. 
Published: December 2003

AbstractPromoting software reuse is probably the most promising approach to the cost‐effective development and evolution of quality software. An example of reuse is the successful adoption of software product families in industry. In a product family context, software architects anticipate product variation and design architectures that support product derivation in both space (multiple contexts) and time (changing contexts). Product derivation is based on the concept of variability: a single architecture and a set of components support a family of products. Modern software product families need to support increasing amounts of variability, leading to a situation where variability engineering becomes of primary concern. Variability is often introduced as an ‘add‐on’ to the system without taking the consequences for more than one lifecycle phase such as design or architecture into account. This paper (1) suggests a Variability Categorization and Classification Model (VCCM) for representing variability in the software lifecycle and (2) discusses a case study of a large‐scale software product family of Magnetic Resonance Imaging (MRI) scanners developed by Philips Medical Systems. The study illustrates how variability can be made an integral part of system development at different levels of abstraction. VCCM has been applied to the scanner family as an analysis tool. Copyright © 2003 John Wiley & Sons, Ltd.
Regulation of the water channel aquaporin‐1: isolation and reconstitution of the regulatory complex
Authors: Abu‐Hamdah Rania , Cho Won‐Jin , Cho Sang‐Joon , Jeremic Aleksandar , Kelly Marie , Ilie Alina Elena , Jena Bhanu P. 
Published: December 2003

AbstractAquaporins (AQP) are involved in rapid and active gating of water across biological membranes. The molecular regulation of AQP is unknown. Here we report the isolation, identification and reconstitution of the regulatory complex of AQP‐1. AQP‐1 and Gαi3have been implicated in GTP‐induced gating of water in zymogen granules (ZG), the secretory vesicles in exocrine pancreas. In the present study, detergent‐solubilized ZGs immunoprecipitated with monoclonal AQP‐1 antibody, co‐isolates AQP‐1, PLA2, Gαi3, potassium channel IRK‐8, and the chloride channel ClC‐2. Exposure of ZGs to either the potassium channel blocker glyburide, or the PLA2 inhibitor ONO‐RS‐082, blocked GTP‐induced ZG swelling. RBC known to possess AQP‐1 at the plasma membrane, swell on exposure to the Gαi—agonist mastoparan, and respond similarly to ONO‐RS‐082 and glyburide, as ZGs. Liposomes reconstituted with the AQP‐1 immunoisolated complex from solubilized ZG, also swell in response to GTP. Glyburide or ONO‐RS‐082 abolished the GTP effect. Immunoisolate‐reconstituted planar lipid bilayers demonstrate conductance, which is sensitive to glyburide and an AQP‐1 specific antibody. Our results demonstrate a Gαi3‐PLA2 mediated pathway and potassium channel involvement in AQP‐1 regulation.
Sexual dysfunction among patients treated with antidepressants—a Hungarian retrospective study
Authors: Osváth P. , Fekete S. , Vörös V. , Vitrai J. 
Published: December 2003

AbstractThe authors have investigated the incidence and several aspects of sexual problems in Hungarian outpatients (N = 637) treated by antidepressive medication. In this multicentre epidemiological survey the sexual dysfunctions (SD) was assessed by psychiatrists using structured interviews. Seventy-eight of the sample has sexual problems, more than half of them mentioned SD after starting antidepressive medication. Comparing various groups of antidepressants, patients taking a RIMA compound reported the occurrence of SD not so often as in TCA or SSRI groups, where the rate of SD was very high. Authors pointed out that physicians have to pay special attention to this problem in everyday clinical practice, since the recognition and treatment of sexual dysfunction is critical for the patient’s satisfaction, medication compliance and the quality of life.
A 15-year follow-up study of patients with panic disorder
Authors: Andersch Sven , Hetta Jerker 
Published: December 2003

AbstractBackgroundPanic disorder (PD) is generally regarded as a chronic condition with considerable variation in severity of symptoms.AimsTo describe the long-term outcome of naturalistically treated PD.MethodsFifty-five outpatients with PD, who participated in a placebo-controlled drug trial of the efficacy of alprazolam and imipramine 15 years ago were reassessed with the same instruments used in the original study.ResultsComplete recovery (no panic attacks and no longer on medication during the last 10 years) was seen in 18% of patients, and an additional 13% recovered but were still on medication. Fifty-one percent experienced recurrent anxiety attacks whereas 18% still met diagnostic criteria for PD. The incidence of agoraphobia decreased from 69% to 20%. Patients with agoraphobia at admission tended to have a poorer long-term outcome according to daily functioning compared with patients without agoraphobia at admission, although both groups reported improved daily functioning at follow-up. Maintenance medication was common. No benzodiazepine abuse was reported.ConclusionPD has a favourable outcome in a substantial proportion of patients. However, the illness is chronic and needs treatment. The short-term treatment given in the drug trial had no influence on the long-term outcome.
Depressive psychopathology and adverse childhood experiences in eating disorders
Authors: Speranza Mario , Atger Frederic , Corcos Maurice , Loas Gwenolé , Guilbaud Olivier , Stéphan Philippe , Perez-Diaz Fernando , Halfon Olivier , Luc Venisse Jean , Bizouard Paul , Lang François , Flament Martine , Jeammet Philippe 
Published: December 2003

AbstractPurposeThe aim of this paper was to investigate the diagnostic specificity of the self-critical and dependent depressive experiences in a clinical sample of eating disorder patients and to explore the impact of adverse childhood experiences on these dimensions of personality.MethodA sample of 94 anorexic and 61 bulimic patients meeting DSM-IV criteria and 236 matched controls were assessed with the Depressive Experience Questionnaire (DEQ), the abridged version of the Beck Depression Inventory (BDI) and the AMDP Life Events Inventory. Subjects presenting a major depression or a comorbid addictive disorder were excluded from the sample using the Mini International Neuropsychiatric Interview (MINI).ResultsAnorexic and bulimic patients showed higher scores than controls on both self-criticism and dependency sub-scales of the DEQ. Bulimic patients scored significantly higher than anorexic patients on self-criticism and reported more adverse childhood experiences. Finally, negative life events correlated only with self-criticism in the whole sample.DiscussionDifferences in the DEQ Self-Criticism between anorexics and bulimics could not be accounted for by depression since bulimic patients did not show higher BDI levels compared to anorexic patients and depressive symptoms measured with the BDI were not found to be significant predictors of diagnostic grouping in a logistic multiple regression.ConclusionThis study supports the diagnostic specificity of the dependent and self-critical depressive dimensions in eating disorders and strengthens previous research on the role of early experiences in the development of these disorders.
The Spielberger trait anxiety inventory measures more than anxiety
Authors: Caci Hervé , Baylé Franck J. , Dossios Christelle , Robert Philippe , Boyer Patrice 
Published: December 2003

AbstractObjectiveResearchers tried to explain the overlap between anxiety and depression by suggesting that some items of self-administered questionnaires were badly selected and that both constructs should rather be considered as multidimensional. Thus, we hypothesise that the Spielberger trait anxiety inventory (TAI) includes items related to depression.MethodA non-clinical sample of 193 subjects filled out the TAI and the Hospitalised Anxiety–Depression Scale. Factors were postulated on the basis of item content and submitted to confirmatory factor analysis (CFA).ResultsWe found five factors: a 10-item anxiety factor containing three factors, a four-item unsuccessfulness factor correlated with the HADS anhedonia factor, and a six-item happiness factor.ConclusionThe TAI scale encompasses measures of anxiety, depression and well-being. Consequently, the overlap with other measures of depression may result from item selection. This work awaits replication in independent normal and pathological samples.
Psychological stress and cortisol secretion in anhedonic alcoholic men
Authors: Marra D. , Warot D. , Berlin I. , Hispard E. , Dally S. 
Published: December 2003

AbstractWe investigated plasma cortisol in a psychological stress paradigm in seven weaned anhedonic alcoholics in comparison with seven age-matched healthy controls. Alcoholics had significantly higher mean plasma cortisol at baseline and no increase following a psychological stress paradigm. Anhedonic alcoholics judged the experimental situation less agreeable than controls. Anhedonic alcoholics may have blunted cortisol response to psychological stress.
Differential diagnosis using the MMPI-2: Goldberg’s index revisited
Authors: Egger Jos I.M. , Delsing Peter A.M. , De Mey Hubert R.A. 
Published: December 2003

AbstractBackgroundThe Minnesota Multiphasic Personality Inventory (MMPI-2) often supports clinical decision-making in complex diagnostic problems like differentiating neurosis from psychosis and psychosis from bipolar disorder. The MMPI Goldberg index, an arithmetical combination of five clinical scales, has been considered to provide a good estimate for discriminating between neurotic and psychotic profiles. Similarly, the MMPI-2 Personality Psychopathology Five (PSY-5) scales have been found to be useful in differentiating diagnostic categories.MethodThis study evaluates these findings in a sample of psychiatric patients diagnosed with depressive, psychotic, or bipolar disorder using ANOVA and discriminant analysis.ResultsResults corroborate the validity of Goldberg’s index and find MMPI-2 PSY-5 scale Disconstraint to significantly differentiate between psychotic and bipolar-I disorder.ConclusionThe MMPI-2 Goldberg index and PSY-5 scales can offer a useful contribution to the differential diagnosis of depressive, psychotic and bipolar disorder.
Depressive episodes–evidence for a causal role of primary anxiety disorders?
Authors: Wittchen Hans-Ulrich , Beesdo Katja , Bittner Antje , Goodwin Renee D. 
Published: December 2003

AbstractAnxiety and depressive disorders are common mental disorders in general population, imposing tremendous burden on both affected persons and society. Moreover, comorbidity between anxiety and depressive conditions is high, leading to substantial disability and functional impairment. Findings consistently suggest that anxiety disorders are primary to depression in the majority of comorbid cases. Yet, the question of whether anxiety disorders are risk factors for depression, and potentially even causal risk factors for the first onset of depression, remains unresolved. Recent results have shown that anxiety disorders increase the risk for subsequent depression, and also affect the course of depression, resulting in a poorer prognosis. Further, some results suggest a dose–response-relationship in revealing that a higher number of anxiety disorders and more severe impairment associated with anxiety disorders additionally increase the risk for subsequent depression. The goal of this paper is to review recent literature, summarize implications of previous findings, and suggest directions for future research regarding preventive and intervention strategies.
Bone tissue engineering in a critical size defect compared to ectopic implantations in the goat
Authors: Kruyt Moyo C. , Dhert Wouter J. A. , Yuan Huipin , Wilson Clayton E. , van Blitterswijk Clemens A. , Verbout Abraham J. , de Bruijn Joost D. 
Published: December 2003

AbstractSince the application of the autologous bone graft, the need for an alternative has been recognized. Tissue engineering (TE) of bone by combining bone marrow stromal cells (BMSCs) with a porous scaffold, is considered a promising technique. In this study we investigated the potential of tissue engineered bone to heal a critical sized defect in the goat. Orthotopic bone formation was compared to ectopic bone formation in comparable constructs.TE constructs were prepared from goat BMSCs and porous biphasic calcium phosphate ceramic scaffolds. These constructs and scaffolds without cells were implanted paired in critical sized iliac wing defects. Comparable samples were implanted intramuscularly. After 9 (n = 7) and 12 (n = 8) weeks implantation, the samples were analyzed histomorphometrically.After 9‐weeks implantation in the iliac wing defect, significantly more bone apposition was found in the TE condition. After 12 weeks, the defects were almost completely filled with bone, but no significant advantage of TE was determined anymore. This contrasted with the intramuscular samples where TE implants showed significantly more bone at both time points.In conclusion, bone TE is feasible in critical sized defects. However, when appropriate osteoconductive/inductive materials are applied the effect of cell seeding may be temporary. © 2003 Orthopaedic Research Society. Published by Elsevier Ltd. All rights reserved.
Serum‐free media for periosteal chondrogenesis in vitro
Authors: Fitzsimmons James S. , Sanyal Arunik , Gonzalez Carlos , Fukumoto Takumi , Clemens Victoria R. , O'Driscoll Shawn W. , Reinholz Gregory G. 
Published: December 2003

AbstractOrgan culture studies involving whole explants of periosteum have been useful for studying chondrogenesis, but to date the standard culture model for these explants has required the addition of fetal bovine serum to the media. Numerous investigators have succeeded in culturing chondrocytes and embryonic cells in serum‐free conditions but there have been no studies focused on achieving a defined, serum‐free media for culturing periosteal explants. The purpose of the present investigation was to determine if whole periosteal explants can be grown and produce cartilage in serum‐free conditions, and to define the minimum media supplements that would be conducive to chondrogenesis. 321 periosteal explants were obtained from the medial proximal tibiae of 31 two month‐old NZ white rabbits and cultured using a published agarose suspension organ culture model and DMEM for six weeks. The explants were cultured with and without fetal bovine serum or bovine serum albumin and exposed to transforming growth factor beta alone, a combination of growth factors we call ChondroMix (10 ng/ml transforming growth factor beta, 50 ng/ml basic fibroblast growth factor, and 5 μ/ml growth hormone), and/or ITS+ (2.08 μg/ml each of insulin, transferrin, and selenious acid, plus 1.78 μg/ml linoleic acid and 0.42 mg/ml BSA). Maximal chondrogenic stimulation in this study was observed with the combination of ChondroMix and ITS+. However, the minimal requirement to match or exceed the level of chondrogenic stimulation seen in the standard model (TGF‐1 in 10% FBS) was achieved simply by the addition of 2.0 μg/ml insulin in 0.1% BSA‐containing medium (p< 0.05). Therefore, based on our results, it would be reasonable to assume that insulin is the component in ITS+ responsible for the observed increase in total cartilage growth. Lower concentrations of insulin were not effective, suggesting that the observed effect of insulin requires activation of the IGF‐1 receptor. © 2003 Orthopaedic Research Society. Published by Elsevier Ltd. All rights reserved.
$L^{p}$ BOUNDS FOR MARCINKIEWICZ INTEGRALS
Authors: Ding Yong , Pan Yibiao 
Published: December 2003

AbstractIn this paper the authors establish the $L^p$ boundedness for several classes of Marcinkiewicz integral operators with kernels satisfying a condition introduced by Grafakos and Stefanov in Indiana Univ. Math. J.47 (1998), 455–469.AMS 2000 Mathematics subject classification: Primary 42B25; 42B99
CONDITIONS FOR SOLVABILITY OF THE HARTMAN–WINTNER PROBLEM IN TERMS OF COEFFICIENTS
Authors: Chernyavskaya N. A. , Shuster L. 
Published: December 2003

AbstractThe Equation (1) $(r(x)y')'=q(x)y(x)$ is regarded as a perturbation of (2) $(r(x)z'(x))'=q_1(x)z(x)$. The functions $r(x)$, $q_1(x)$ are assumed to be continuous real valued, $r(x)>0$, $q_1(x)\ge0$, whereas $q(x)$ is continuous complex valued. A problem of Hartman and Wintner regarding the asymptotic integration of (1) for large $x$ by means of solutions of (2) is studied. Sufficiency conditions for solvability of this problem expressed by means of coefficients $r(x)$, $q(x)$, $q_1(x)$ of Equations (1) and (2) are obtained.AMS 2000 Mathematics subject classification: Primary 34E20
SYMPLECTIC CONNECTIONS WITH A PARALLEL RICCI CURVATURE
Authors: Boubel Charles 
Published: December 2003

AbstractA symplectic connection on a symplectic manifold, unlike the Levi-Civita connection on a Riemannian manifold, is not unique. However, some spaces admit a canonical connection (symmetric symplectic spaces, Kähler manifolds, etc.); besides, some ‘preferred’ symplectic connections can be defined in some situations. These facts motivate a study of the symplectic connections, inducing a parallel Ricci tensor. This paper gives the possible forms of the Ricci curvature on such manifolds and gives a decomposition theorem (linked with the holonomy decomposition) for them.AMS 2000 Mathematics subject classification: Primary 53B05; 53B30; 53B35; 53C25; 53C55
DECREASE OF BOUNDED HOLOMORPHIC FUNCTIONS ALONG DISCRETE SETS
Authors: Pau Jordi , Thomas Pascal J. 
Published: December 2003

AbstractWe provide uniqueness results for holomorphic functions in the Nevanlinna class which bridge those previously obtained by Hayman and by Lyubarskii and Seip. In particular, we propose certain classes of hyperbolically separated sequences in the disc, in terms of the rate of non-tangential accumulation to the boundary (the outer limits of this spectrum of classes being, respectively, the sequences with a non-tangential cluster set of positive measure, and the sequences satisfying the Blaschke condition). For each of those classes, we give a critical condition of radial decrease on the modulus which will force a Nevanlinna class function to vanish identically.AMS 2000 Mathematics subject classification: Primary 30D50; 30D55
DUALITY AND CONTACT OF HYPERSURFACES IN $\mathbb{R}^4$ WITH HYPERPLANES AND LINES
Authors: Nabarro A. C. 
Published: December 2003

AbstractGiven an embedded hypersurface $M$ in $\mathbb{R}^4$ we consider families of projections $H$ of $M$ to lines and families of projections $P$ of $M$ to 3-spaces. We characterize generically the singularities of these projections. We also show that there is a duality relation between some strata of the bifurcation sets of $H$ and $P$, and deduce geometric properties about these sets.AMS 2000 Mathematics subject classification: Primary 58K05. Secondary 58K40
SIMILARITY AND THE POINT SPECTRUM OF SOME NON-SELFADJOINT JACOBI MATRICES
Authors: Janas Jan , Malejki Maria , Mykytyuk Yaroslav 
Published: December 2003

AbstractIn this paper spectral properties of non-selfadjoint Jacobi operators $J$ which are compact perturbations of the operator $J_0=S+\rho S^*$, where $\rho\in(0,1)$ and $S$ is the unilateral shift operator in $\ell^2$, are studied. In the case where $J-J_0$ is in the trace class, Friedrichs’s ideas are used to prove similarity of $J$ to the rank one perturbation $T$ of $J_0$, i.e. $T=J_0+(\cdot,p)e_1$. Moreover, it is shown that the perturbation is of ‘smooth type’, i.e. $p\in\ell^2$ and$$ \varlimsup_{n\rightarrow\infty}|p(n)|^{1/n}\le\rho^{1/2}. $$When $J-J_0$ is not in the trace class, the Friedrichs method does not work and the transfer matrix approach is used. Finally, the point spectrum of a special class of Jacobi matrices (introduced by Atzmon and Sodin) is investigated.AMS 2000 Mathematics subject classification: Primary 47B36. Secondary 47B37
COUNTABLE VERSUS UNCOUNTABLE RANKS IN INFINITE SEMIGROUPS OF TRANSFORMATIONS AND RELATIONS
Authors: Higgins P. M. , Howie J. M. , Mitchell J. D. , Ruškuc N. 
Published: December 2003

AbstractThe relative rank $\rank(S:A)$ of a subset $A$ of a semigroup $S$ is the minimum cardinality of a set $B$ such that $\langle A\cup B\rangle=S$. It follows from a result of Sierpiński that, if $X$ is infinite, the relative rank of a subset of the full transformation semigroup $\mathcal{T}_{X}$ is either uncountable or at most $2$. A similar result holds for the semigroup $\mathcal{B}_{X}$ of binary relations on $X$.A subset $S$ of $\mathcal{T}_{\mathbb{N}}$ is dominated (by $U$) if there exists a countable subset $U$ of $\mathcal{T}_{\mathbb{N}}$ with the property that for each $\sigma$ in $S$ there exists $\mu$ in $U$ such that $i\sigma\le i\mu$ for all $i$ in $\mathbb{N}$. It is shown that every dominated subset of $\mathcal{T}_{\mathbb{N}}$ is of uncountable relative rank. As a consequence, the monoid of all contractions in $\mathcal{T}_{\mathbb{N}}$ (mappings $\alpha$ with the property that $|i\alpha-j\alpha|\le|i-j|$ for all $i$ and $j$) is of uncountable relative rank.It is shown (among other results) that $\rank(\mathcal{B}_{X}:\mathcal{T}_{X})=1$ and that $\rank(\mathcal{B}_{X}:\mathcal{I}_{X})=1$ (where $\mathcal{I}_{X}$ is the symmetric inverse semigroup on $X$). By contrast, if $\mathcal{S}_{X}$ is the symmetric group, $\rank(\mathcal{B}_{X}:\mathcal{S}_{X})=2$.AMS 2000 Mathematics subject classification: Primary 20M20
CAPACITIES AND JACOBI MATRICES
Authors: Sebbar Ahmed , Falliero Thérèse 
Published: December 2003

AbstractIn this paper, we use the theorem of Burchnall and Shaundy to give the capacity of the spectrum $\sigma(A)$ of a periodic tridiagonal and symmetric matrix. A special family of Chebyshev polynomials of $\sigma(A)$ is also given. In addition, the inverse problem is considered: given a finite union $E$ of closed intervals, we study the conditions for a Jacobi matrix $A$ to exist satisfying $\sigma(A)=E$. We relate this question to Carathéodory theorems on conformal mappings.AMS 2000 Mathematics subject classification: Primary 31B15; 30C20; 39A70
SELF-INTERSECTIONS OF SURFACES AND WHITNEY STRATIFICATIONS
Authors: Achilles Rüdiger , Manaresi Mirella 
Published: December 2003

AbstractLet $X$ be a surface in $\mathbb{C}^n$ or $\mathbb{P}^n$ and let $C_{X}(X\times X)$ be the normal cone to $X$ in $X\times X$ (diagonally embedded). For a point $x\in X$, denote by $g(x):=e_x(C_X(X\times X))$ the multiplicity of $C_X(X\times X)$ at $x$. It is a former result of the authors that $g(x)$ is the degree at $x$ of the Stückrad–Vogel cycle $v(X,X)=\sum_C j(X,X;C)[C]$ of the self-intersection of $X$, that is, $g(x)=\sum_Cj(X,X;C)e_x(C)$. We prove that the stratification of $X$ by the multiplicity $g(x)$ is a Whitney stratification, the canonical one if $n=3$. The corresponding result for hypersurfaces in $\mathbb{A}^n$ or $\mathbb{P}^n$, diagonally embedded in a multiple product with itself, was conjectured by van Gastel. This is also discussed, but remains open.AMS 2000 Mathematics subject classification: Primary 32S15. Secondary 13H15;14C17