bluuebunny/crossref_metadata_2025_split huggingface dataset:
Nicotinamide Loaded Chitosan Nanocomplex Shows Improved Anticancer Potential:
Molecular Docking, Synthesis, Characterization and In vitro Evaluations
Authors: Metwaly Ahmed M. , Abu-Saied Mohamed A. , Gobaara Ibraheem M.M. , Lotfy Asmaa M. , Alsfouk Bshra A. , Elkaeed Eslam B. , Eissa Ibrahim H. 
Published: January 2024

Abstract:
This study aimed to prepare and characterize chitosan nanoparticles encapsulating
a nicotinamide derivative (Ni-CS-NP). Additionally, the therapeutic effectiveness,
cytotoxicity, selectivity, and immunomodulatory properties of Ni-CS-NP were evaluated
in human breast and colon cancer cell lines. Chitosan nanoparticles have shown potential
as drug delivery carriers due to their biocompatibility and controlled release properties.
Encapsulating a nicotinamide derivative further enhances the therapeutic potential of these
nanoparticles. Computational studies were employed to validate the binding interactions,
providing crucial insights into the formulation's stability and effectiveness. The primary
objective was to assess the cytotoxicity and safety profiles of Ni-CS-NP in human cancer
cell lines. Moreover, this study aimed to investigate the specific mechanisms underlying
its cytotoxic effects, including its impact on cell cycle progression, apoptosis induction, and immunomodulation.
Ni-CS-NP were synthesized using the ionic gelation method and characterized using Fourier-transform
infrared spectroscopy (FT-IR), scanning electron microscopy (SEM), transmission electron microscopy
(TEM), and thermo gravimetric analysis. The cytotoxicity was evaluated in breast and colon cancer cell lines
through the MTT assay. Selectivity indices were calculated to determine the safety profiles. The inhibition of
VEGFR-2, induction of apoptosis, cell cycle disruption, and immunomodulatory effects were assessed through
molecular assays. Computational analysis demonstrated favorable binding interactions through the Ni-CS-NP
complex. The characterization studies confirmed the successful synthesis of Ni-CS-NP with well-defined
structural and thermal properties. Ni-CS-NP exhibited remarkable cytotoxicity with a superior safety profile
against MCF7 and HCT 116 cell lines showing IC50 values of 2.32 and 2.70 μM, respectively, surpassing sorafenib's
efficacy (IC50 = 4.12 and 7.55 μM, respectively). Additionally, Ni-CS-NP effectively inhibited
VEGFR-2, induced both early and late apoptosis, and disrupted the cell cycle progression in MCF7 cells. Notably,
Ni-CS-NP demonstrated significant immunomodulatory effects by reducing TNF-α and IL-2 levels
compared to dexamethasone. The encapsulation of a nicotinamide derivative within chitosan nanoparticles
(Ni-CS-NP) through the ionic gelation method proved successful. Ni-CS-NP displayed potent cytotoxicity,
superior safety profiles, and promising immunomodulatory effects in human breast cancer cells. These findings
highlight the potential of Ni-CS-NP as a novel therapeutic agent for breast cancer treatment, warranting
further investigation for clinical applications.
A Brief Meta-analysis and Health Risk Assessment of Lead and Cadmium
in Meat, Liver, and Kidney of Livestock in Iran
Authors: Emami Mohammad Hassan , Mohammadzadeh Samane , Karimi Raheleh , Amerizadeh Atefeh , Fahim Alireza , Dehkordi Sayed Ali Ehsan , Maghool Fatemeh 
Published: January 2024

Background:
Red meat from livestock is an excellent source of high-quality protein, vitamins,
and minerals

Objective:
This meta-analysis aimed to investigate the levels of two of the most toxic heavy metals;
lead (Pb) and cadmium (Cd) in meat and edible offal (liver and kidney) of livestock (sheep,
buffalo, and cow) in Iran with assessing their health risk of developing cancer.

Methods:
A systematic search was conducted covering ISI Web of Science, PubMed, and Google
Scholar. Finally, data from 4 articles including 624 samples were analysed.

Results:
Pooled results show that the mean concentrations of Pb and Cd were 0.18 mg/kg and
0.13 mg/kg respectively which were both higher than their eligible maximum limits by
FAO/WHO. The Estimated Daily Intake (EDI) of Pb and Cd in meat, liver, and kidney for adults
and children was lower than the Total Daily Intake (TDI) limits. The consumers' non-carcinogenic
risk (THQ) for meat consumption was generally safe in terms of Cd and Pb in all cities except for
Pb in Hamadan which was greater than one (unsafe) for both adults and children. Carcinogenic
Risk (CR) for meat consumption was generally safe or within the acceptable range in terms of Cd
and Pb in all cities except for Pb in Hamadan which had a Pb-CR greater than safe/permissible level
for children.

Conclusion:
It can be concluded that the dangerous levels of CR and THQ of meat in terms of Pb
in Hamadan warrant concern and further study.
Motion-resolved 3D Pulmonary MRI Reconstruction using Sinusoidal
Representation Networks
Authors: Zou Qing 
Published: January 2024

Background::
Deep learning reconstruction for free-breathing pulmonary MRI.

Objective::
To propose a motion-resolved 3D pulmonary MRI reconstruction scheme using the sinusoidal representation network (SIREN).

Methods::
The proposed scheme learns the registration maps using SIREN to register an averaging image to get the final reconstructions. The learning of the
network relies only on the undersampled data from the specific subject. The usage of the network for outputting the registration maps enables a
memory-efficient algorithm, as outputting registration maps instead of images only requires small networks. The training of the network based on
only undersampled data enables an unsupervised learning scheme, which makes the proposed scheme useful in cases in which fully sampled data is
not available.

Results::
We compare the proposed SIREN-based motion-resolved reconstruction with two state-of-the-art methods for ten datasets. Both visual and
quantitative comparison indicates the better performance of the proposed method.

Conclusion::
In conclusion, the use of SIREN for 3D pulmonary MRI reconstruction allows for the efficient and accurate reconstruction of data that has been
undersampled.
Theranostic Nanomaterials to Overcome the Challenges in Peptide-based
Cancer Therapy
Authors: Selvaraj Saranya , Amarasekara Yasuri , Perera Inoka C. , Weerasinghe Laksiri 
Published: January 2024

:
Globally, the number of cancer cases and death rates are increasing, making it necessary to develop new and improved medications for the treatment of cancer.Owing to a broad
range of physio-chemical properties, Antimicrobial Peptides (AMPs) possessing tumoricidal
properties and Anticancer Peptides (ACPs) are promising alternatives for enhanced cancer therapy. Recently, biopharmaceuticals have changed the rules of radiation therapy and chemotherapy
by introducing peptide therapy for cancer treatments. However, several limitations obstruct the
clinical efficacy of peptide-based cancer therapies, which include limited target specificity, oral
intake, and half-life payloads. The integration of theranostic nanomaterials could be facilitated as
a transformative strategy to address these challenges and enhance the potential of peptide-based
cancer therapy. Increasing applications of recent times of peptide-nano hybrids have addressed
the crucial issues related to conventional peptide-based drug therapy by enhancing the druggability. This review aims to explore the impact of nano-formulated peptides as an anticancer agent,
highlighting the involvement of nanotechnology as an enabling tool.
In-vitro and In Silico Assessment of Anti-inflammation Properties of Saponarin Extracted from Hordeum Vulgare
Authors: Boyina Revathi , Kosanam Sreya , Bhimana Sasidhar , Gudimitla Raveendra Babu , Duraiswamy Dhachinamoorthi 
Published: January 2024

Background:
Hordeum vulgare, commonly known as Barley grass, is a historically significant cultivated plant with profound implications for societies, agricultural sciences, and human nutrition. It has been valued for both sustenance and its potential medicinal properties

Objective:
This study aims to comprehensively investigate the medicinal properties of Hordeum vulgare, focusing on its potential therapeutic benefits and anti-inflammatory properties. Addition-ally, we seek to quantify and compare the phytochemical content of two distinct extracts: Barley Grass Hexane Extract (BGHE) and Barley grass aqueous extract (BGAQ).

Methods:
We quantified the phytochemical contents of BGHE and BGAQ and evaluated their anti-inflammatory effects using UV spectroscopy at 560 nm, coupled with the RBC membrane stabilization technique. Subsequently, we conducted in silico studies to assess the in vitro anti-inflammatory potential of Barley grass leaf extracts.

Results:
Both BGHE and BGAQ demonstrated significant inhibitory effects on inflammation com-pared to the control group. However, BGHE exhibited superior anti-inflammatory efficacy when compared to BGAQ, suggesting its role as a potential anti-inflammatory agent. In silico studies further supported the anti-inflammatory potential of Barley grass leaf extracts.

Conclusion:
Hordeum vulgare, or Barley grass, offers a wealth of health benefits, including anti-inflammatory, anti-diabetic, anti-cancer, antioxidant, anti-acne, and anti-depressant properties. These properties contribute to improved immunity, reduced cardiovascular disorders, and alleviation of fatigue. The distinct extracts, BGHE and BGAQ, both exhibit promising anti-inflammatory capabilities, but BGHE shows better anti-inflammatory activity. This research sheds light on the therapeutic potential of Barley grass, making it a valuable candidate for further exploration in the field of natural medicine.
A New-fangled COVID-19 Variant, Eris, Might be the One to Lookout in
2023 or far from Over
Authors: Ray Suman Kumar , Mukherjee Sukhes 
Published: January 2024

Abstract:
Coronavirus Disease-19 (COVID-19) is an infectious disease brought on by the extremely pathogenic and contagious severe acute respiratory syndrome-virus-2 (SARS-CoV-2).
The agenda for the COVID-19 pandemic is dynamic and includes recent developments. Seven
variants under monitoring (VUMs), one variant of interest (VOI), XBB.1.5, and their offspring
lineages are currently being actively monitored by WHO. The VUMs are BA.2.75, CH.1.1, BQ.1,
XBB (with the exception of XBB.1.5, XBB.1.16, and XBB.1.9.1), XBF, and XBB.1.16. With 95
countries having reported finding XBB.1.5 (VOI), it is still the most common strain worldwide,
responsible for 47.9% of cases from epidemiological January to March 2023. Seventy nations
discovered XBB.1.5 in February and March 2023 and posted sequencing data to GISAID. Of the
43 nations that uploaded more than 50 sequences, XBB.1.5 prevalence has increased to more than
50% in 11 nations. Over 23000 deaths and 3 million new cases were recorded globally in March
and April 2023. Worldwide detection of a new COVID-19 strain has prompted specialists to
issue a warning that the virus is "circulating unchecked". The Greek goddess of conflict and discord Eris has inspired the nicknaming of EG 5.1, a subvariant of Omicron. The strain is becoming
more prevalent in the USA and cases are increasing in the UK. The severity of each SARS-CoV2 variant has been comparable, although a more severe form might develop. Eris is an ancestor
of Omicron and exhibits some of its characteristics. Reinfection risk can be influenced by a variety of variables, including age, location, and health equity and the COVID-19 vaccine is more or
less effective depending on the strain.
Fruits of Emblica officinalis Linn. and its Phytochemicals in the Prevention
of Ethanol-induced Hepatotoxicity: A Mini-Review
Authors: Baliga Manjeshwar Shrinath , Marakala Vijaya , Anthony Raymond , George Thomas 
Published: January 2024

Abstract::
Excessive alcohol consumption over time is one of the primary causes of liver disease
and death globally. Because there is no effective treatment, the situation has become more complicated,
and the emphasis has shifted to the use of alternative and complementary medicine to
treat liver problems. Herbs with dietary use have played an important part in the treatment of liver
diseases since antiquity. Amla or Indian gooseberry, scientifically known as Phyllanthus emblica
or Emblica officinalis, is a fruiting plant of the Phyllanthaceae family that is used in a variety of
traditional and folk medical systems. The fruits have both dietary and medicinal value and are
used to prevent chemical-induced hepatocarcinogenesis and reduce experimentally induced hyperlipidemia
and metabolic syndrome in laboratory animals. They also have hepatoprotective effects
against a variety of hepatotoxins such as heavy metals, iron overload, ochratoxins, hexachlorocyclohexane,
carbon tetrachloride, therapeutic drugs such as paracetamol, and antitubercular. Amla
fruits and phytochemicals such as quercetin, gallic acid, ellagic acid, and kaempferol are known to
reduce ethanol-induced liver damage, and mechanistic studies have shown that the beneficial effects
of these phytochemicals are mediated in part by free radical scavenging, antioxidant, and
anti-inflammatory effects. This review examines the positive effects of amla fruit and its phytochemicals
for the first time, as well as the mechanisms underlying the protective effects.
IMPLEMENTASI KEBIJAKAN PROGRAM KELUARGA HARAPAN (PKH) DI KOTA KUPANG
Authors: Kiwang Amir Syarifudin 
Published: January 2024

Hope family programs is a program conditional cash assistance to poor families or in international terms known as Conditional Cash Transfers (CCT). Hope family programs intended for help reduce family expenses while increasing investmen for future generations through improving the quality of health and children's education. In the long run, hope family programs expected to break intergenerational poverty chain. As a program Conditional assistance open access to poor families especially pregnant women and children's to utilize various health care facilitiesÂ and educational service facilities which are available around them. Hope family programs first implemented in 2007 with scattered target in seven provinces namely DKI Jakarta, East Java, West Java, Gorontalo, North Sulawesi , West Sumatera and East Nusa Tenggara (Kupang City). Facts show that Policy Implementation hope family programs has gone well since 2007. In kupang City up to the year 2018 there are around 6.019 heads of family recipient of the family Hope program (latest data 2018, after deducting the participants who leave). Constraints to implementing a family program of hope is a cross-sectoral communication issue and bureaucratic structure in the process of implementing a family program of hope so that it often causes problems in the field. Participants of the Family Hope Program who does not carry out commitments in accordance with verification results will get sanctions in the form of discounted amounts of assistance in the current year.Cooperation between operators and facilitators and all stakeholders be the key to success implementation of the family hope program in kupang city.Â Keywords : Policy Implementation, Hope family programs.Â
Laboratory Data Timeliness and Completeness Improves Following Implementation of an Electronic Laboratory Information System in Côte d’Ivoire: Quasi-Experimental Study on 21 Clinical Laboratories From 2014 to 2020
Authors: He Yao , Kouabenan Yves-Rolland , Assoa Paul Henri , Puttkammer Nancy , Wagenaar Bradley H , Xiao Hong , Gloyd Stephen , Hoffman Noah G , Komena Pascal , Kamelan N'zi Pierre Fourier , Iiams-Hauser Casey , Pongathie Adama Sanogo , Kouakou Alain , Flowers Jan , Abiola Nadine , Kohemun Natacha , Amani Jean-Bernard , Adje-Toure Christiane , Perrone Lucy A 
Published: January 2024

Background
The Ministry of Health in Côte d'Ivoire and the International Training and Education Center for Health at the University of Washington, funded by the United States President’s Emergency Plan for AIDS Relief, have been collaborating to develop and implement the Open-Source Enterprise-Level Laboratory Information System (OpenELIS). The system is designed to improve HIV-related laboratory data management and strengthen quality management and capacity at clinical laboratories across the nation.

Objective
This evaluation aimed to quantify the effects of implementing OpenELIS on data quality for laboratory tests related to HIV care and treatment.

Methods
This evaluation used a quasi-experimental design to perform an interrupted time-series analysis to estimate the changes in the level and slope of 3 data quality indicators (timeliness, completeness, and validity) after OpenELIS implementation. We collected paper and electronic records on clusters of differentiation 4 (CD4) testing for 48 weeks before OpenELIS adoption until 72 weeks after. Data collection took place at 21 laboratories in 13 health regions that started using OpenELIS between 2014 and 2020. We analyzed the data at the laboratory level. We estimated odds ratios (ORs) by comparing the observed outcomes with modeled counterfactual ones when the laboratories did not adopt OpenELIS.

Results
There was an immediate 5-fold increase in timeliness (OR 5.27, 95% CI 4.33-6.41; P<.001) and an immediate 3.6-fold increase in completeness (OR 3.59, 95% CI 2.40-5.37; P<.001). These immediate improvements were observed starting after OpenELIS installation and then maintained until 72 weeks after OpenELIS adoption. The weekly improvement in the postimplementation trend of completeness was significant (OR 1.03, 95% CI 1.02-1.05; P<.001). The improvement in validity was not statistically significant (OR 1.34, 95% CI 0.69-2.60; P=.38), but validity did not fall below pre-OpenELIS levels.

Conclusions
These results demonstrate the value of electronic laboratory information systems in improving laboratory data quality and supporting evidence-based decision-making in health care. These findings highlight the importance of OpenELIS in Côte d'Ivoire and the potential for adoption in other low- and middle-income countries with similar health systems.
Enhancing the Efficiency of a Radiation Oncology Department Using Electronic Medical Records: Protocol for Preparing Radiotherapy
Authors: Cheng Hao-Shen , You Weir-Chiang , Chen Ni-Wei , Hsieh Mu-Chih , Tsai Che-Fu , Ho Chia-Jing , Chen Chien-Chih 
Published: January 2024

Background
Electronic medical records (EMRs) streamline medical processes, improve quality control, and facilitate data sharing among hospital departments. They also reduce maintenance costs and storage space needed for paper records, while saving time and providing structured data for future research.

Objective
This study aimed to investigate whether the integration of the radiation oncology information system and the hospital information system enhances the efficiency of the department of radiation oncology.

Methods
We held multidisciplinary discussions among physicians, physicists, medical radiation technologists, nurses, and engineers. We integrated paper records from the radiation oncology department into the existing hospital information system within the hospital. A new electronic interface was designed. A comparison was made between the time taken to retrieve information from either the paper records or the EMRs for radiation preparation. A total of 30 cases were randomly allocated in both the old paper-based system and the new EMR system. The time spent was calculated manually at every step during the process, and we performed an independent 1-tailed t test to evaluate the difference between the 2 systems.

Results
Since the system was launched in August 2020, more than 1000 medical records have been entered into the system, and this figure continues to increase. The total time needed for the radiation preparation process was reduced from 286.8 minutes to 154.3 minutes (P<.001)—a reduction of 46.2%. There was no longer any need to arrange for a nurse to organize the radiotherapy paper records, saving a workload of 16 hours per month.

Conclusions
The implementation of the integrated EMR system has resulted in a significant reduction in the number of steps involved in radiotherapy preparation, as well as a decrease in the amount of time required for the process. The new EMR system has provided numerous benefits for the department, including a decrease in workload, a simplified workflow, and conserving more patient data within a confined space.
Eating Habits and Lifestyle Factors Related to Childhood Obesity Among Children Aged 5-6 Years: Cluster Analysis of Panel Survey Data in Korea
Authors: Lim Heemoon , Lee Hyejung 
Published: January 2024

Background
Childhood obesity has emerged as a major health issue due to the rapid growth in the prevalence of obesity among young children worldwide. Establishing healthy eating habits and lifestyles in early childhood may help children gain appropriate weight and further improve their health outcomes later in life.

Objective
This study aims to classify clusters of young children according to their eating habits and identify the features of each cluster as they relate to childhood obesity.

Methods
A total of 1280 children were selected from the Panel Study on Korean Children. Data on their eating habits (eating speed, mealtime regularity, consistency of food amount, and balanced eating), sleep hours per day, outdoor activity hours per day, and BMI were obtained. We performed a cluster analysis on the children’s eating habits using k-means methods. We conducted ANOVA and chi-square analyses to identify differences in the children’s BMI, sleep hours, physical activity, and the characteristics of their parents and family by cluster.

Results
At both ages (ages 5 and 6 years), we identified 4 clusters based on the children’s eating habits. Cluster 1 was characterized by a fast eating speed (fast eaters); cluster 2 by a slow eating speed (slow eaters); cluster 3 by irregular eating habits (poor eaters); and cluster 4 by a balanced diet, regular mealtimes, and consistent food amounts (healthy eaters). Slow eaters tended to have the lowest BMI (P<.001), and a low proportion had overweight and obesity at the age of 5 years (P=.03) and 1 year later (P=.005). There was a significant difference in sleep time (P=.01) and mother’s education level (P=.03) at the age of 5 years. Moreover, there was a significant difference in sleep time (P=.03) and the father’s education level (P=.02) at the age of 6 years.

Conclusions
Efforts to establish healthy eating habits in early childhood may contribute to the prevention of obesity in children. Specifically, providing dietary guidance on a child’s eating speed can help prevent childhood obesity. This research suggests that lifestyle modification could be a viable target to decrease the risk of childhood obesity and promote the development of healthy children. Additionally, we propose that future studies examine long-term changes in obesity resulting from lifestyle modifications in children from families with low educational levels.