bluuebunny/crossref_metadata_2025_split huggingface dataset:
Inter-Organizational Alignment and Implementation Outcomes in Integrated Mental Healthcare for Children and Adolescents: A Cross-Sectional Observational Study
Authors: Zhang Yanchen , Larson Madeline , Ehrhart Mark G. , King Kevin , Lyon Aaron R. , Locke Jill , Cook Clayton 
Published: January 2024

Abstract
Background: Integrated care involves care provided by a team of professionals, often in non-traditional settings. A common example worldwide is integrated school-based mental health (SBMH), which involves externally employed clinicians providing care at schools. Integrated mental healthcare can improve the accessibility and efficiency of evidence-based practices (EBPs) for vulnerable populations suffering from fragmented traditional care. However, integration can complicate EBP implementation due to overlapping organizational contexts, diminishing the public health impact. Emerging literature suggests that EBP implementation may benefit from the similarities in the implementation context factors between the different organizations in integrated care, which we termed inter-organizational alignment (IOA). This study quantitatively explored whether and how IOAs in general and implementation context factors are associated with implementation outcomes in integrated SBMH.
Methods: SBMH clinicians from community-based organizations (CBOs; nclinician=27) and their proximal student-support school staff (nschool=99) rated their schools and CBOs (clinician only) regarding general (organizational culture and molar climate) and implementation context factors (Implementation Climate and Leadership), and nine common implementation outcomes (e.g., treatment integrity, service access, acceptability). The levels of IOA were estimated by intra-class correlations (ICCs). We fitted multilevel models to estimate the standalone effects of context factors from CBOs and schools on implementation outcomes. We also estimated the 2-way interaction effects between CBO and school context factors (i.e., between-setting interdependence) on implementation outcomes.
Results: The IOA in general context factors exceeded those of implementation context factors. The standalone effects of implementation context factors on most implementation outcomes were larger than those of general context factors. Similarly, implementation context factors between CBOs and schools showed larger 2-way interaction effects on implementation outcomes than general context factors.
Conclusions: This study preliminarily supported the importance of IOA in context factors for integrated SBMH. The findings shed light on how IOA in implementation and general context factors may be differentially associated with implementation outcomes across a broad array of integrated mental healthcare settings.
A Comparative Analysis Between Intraoperative Fluorescein Sodium Videoangiography and Postoperative Imaging for Evaluating Clipped Intracranial Aneurysms
Authors: Dellaretti Marcos , Soares André Guimarães , Lima Allan Douglas de Oliveira , de Melo Matheus Tavares , Acherman Natalia Dilella , de Almeida Júlio Cesar , Gonçalves Vitor de Deus da Rocha Ribeiro , Costa Bruno Silva 
Published: January 2024

Abstract
Comparing the findings of intraoperative fluorescein sodium videoangiography (FL-VA) and post operative Computed Tomography Angiography (CTA), this study aims to assess whether FL-VA is a suitable modality for intraoperative evaluation of aneurysmal obliteration and the patency of parent and adjacent vessels. This study is an observational prospective analysis focused on patients who underwent surgery for aneurysms at the Department of Neurosurgery, Santa Casa BH, Belo Horizonte, Minas Gerais, from December 2021 to September 2022. Postoperative CTA was conducted in 54 patients (61 aneurysms). The results of the CTA revealed complete occlusion in 51 out of the 61 aneurysms, accounting for 83.6% of the cases. FL-VA revealed complete occlusion in 93.4% of the studied aneurysms (57 out of 61). Ten cases of discordance between FL-VA and CTA were identified: One patient was indicated as a neck remnant in FL-VA, but CT angiography revealed a residual aneurysm; one patient CT angiography showed neck remnant and stenosis in branching vessels, that it was not identified by FL-VA; five aneurysms had neck remnants, and three cases had stenosis in branching vessels, which were not observed in FL-VA but were detected in CTA. No studied factor showed significant association with the discordance observed between FL-VA and CT angiography. The results of this study contribute to the increasing evidence that supports FL-VA as a highly valuable modality for the intraoperative assessment of aneurysmal obliteration and the patency of parent and adjacent vessels
A fault diagnosis technique based on Multi-domain Features and RelifF-Bayes-KNN
Authors: Wang Bing , Xiong Hu 
Published: January 2024

Abstract
In order to improve the fault diagnosis efficiency of rotating mechanisms such as rolling bearings, a fault diagnosis model based on multi-domain features and RelifF feature selection-Bayesian optimized K nearest neighbor (abbreviated as MDF-Relief-Bayes-KNN) is proposed in this paper. Firstly, processing fine-grained multi-scale analysis (abbreviated as FGMA) on the vibration signal and extracting fine-grained multi-scale sample entropy (abbreviated as FGMSE) to characterize the nonlinear complexity characteristics in multi-scale quantitatively. Then, multi-dimensional time-domain features are extracted to quantitatively describe the time-domain statistical features of the signal. Multi-domain features are constructed by combining the two types of features. Considering information redundancy in multi-domain features, ReliefF method is introduced for feature selection and a simplified feature vector is obtained. Bayesian Optimization (abbreviated as BO) is imported to optimize the distance type and k (the nearest neighbors’ number) of k-Nearest Neighbor (abbreviated as KNN) model, and Bayes-KNN fault diagnosis model is established. An instance analysis on Case Western Reserve University rolling bearing dataset shows that the average 10-folders CV accuracy of the proposed technique can reach 99.24%. The selection of feature vectors is also scientific and effective when adopting different features. Compared with different fault diagnosis models such as Support vector machine (abbreviated as SVM), Naive Bayes (abbreviated as NB), Binary classification decision tree (abbreviated as BDT) and Linear discriminant analysis (abbreviated as LDA), the proposed technique has high accuracy and calculation speed, and it is a kind of fault diagnosis method with potential application.
Association between systemic immune-inflammation index and psoriasis: A cross-sectional study
Authors: Bo Yang , Zhong Xiaojing , Ren Qingjun , Xiang Yanping , Luo Nana , Chen Xingyin , Ma Zuchao , Hao Pingsheng 
Published: January 2024

Abstract

Objectives
The Systemic Immune-inflammatory Index (SII), an emergent biomarker for inflammation, has recently garnered attention. Psoriasis, characterized by its immune-inflammatory nature, presents an intriguing domain for exploring potential associations with SII. This investigation is poised to unravel the complexities of this relationship.
Methods
Leveraging data from the National Health and Nutrition Examination Survey (NHANES), spanning five distinct cycles (2003–2004, 2005–2006, 2009–2010, 2011–2012, and 2013–2014), this cross-sectional study meticulously calculated the SII, taking into account lymphocyte, neutrophil, and platelet counts. Questionnaire data from individuals with psoriasis were meticulously analyzed. An array of statistical methodologies was employed to discern the linear and non-linear relationships between SII and psoriasis, including multivariate regression, subgroup analyses, smoothed curve fitting, and threshold effect analyses.
Results
Encompassing a demographic of 23,825 Americans, this population-based study identified 623 individuals (2.61%) with psoriasis. Following a rigorous adjustment for pivotal covariates such as age, gender, and race, multivariate logistic regression analyses unveiled a significant and positive correlation between SII and psoriasis (OR = 1.14, 95% CI = 1.01–1.29, P = 0.0286), with the interaction test demonstrating robustness in this association. Intriguingly, the relationship between SII and psoriasis was elucidated to be non-linear, as evidenced by a two-stage linear regression model, pinpointing an inflection point at 790.4 (1,000 cells/l).
Conclusion
The present study establishes an independent association between a self-reported history of psoriasis and SII. Moreover, it delineates SII as an independent risk factor for psoriasis at levels below 790.4 (1,000 cells/l), thereby contributing valuable insights into the immunological landscape of psoriasis.
The co-occurrence of sarcoidosis and anti-PLA2R-associated membranous nephropathy in a patient with underlying genetic susceptibility
Authors: DING Ying , Li WAN , Qu Zhen , Yu Feng 
Published: January 2024

Abstract
Background
Sarcoidosis is a multisystemic inflammatory disease, characterized by the presence of non-caseating, epithelioid granulomas. Glomerular disease in patients with sarcoidosis is rare and membranous nephropathy (MN) is cited as the most common. The association between the two diseases remained unclear. This article reported a case of co-occurrence of sarcoidosis and anti-PLA2R-associated MN, to provide a possible relationship between these two entities.
Patient concerns:
A 61-year-old Chinese Han woman with a history of sarcoidosis was admitted to our hospital for nephrotic syndrome (NS).
Diagnosis:
Her sarcoidosis was diagnosed according to the adenopathy observed on the computed tomography (CT) scan and the biopsy of the right supraclavicular lymph node. The MN presented with nephrotic syndrome with a PLA2R antibody titer of 357RU/ml, and the final diagnosis was based on a renal biopsy.
Intervention:
The patient’s sarcoidosis was remitted after treatment with prednisone. One year later MN was diagnosed, and she was treated with prednisone combined with calcineurin inhibitors, based on a full dose of renin-angiotensin system (RAS) inhibitor.
Outcomes:
The patient's sarcoidosis had been in remission while the MN was recurrent, and her renal function deteriorated to end-stage renal disease 6 years later due to discontinuation of immunosuppression. A genetic test led to identifying the HLA-DRB1*0301 and HLA-DRB1*150 genes associated with both sarcoidosis and MN, which provides a possible explanation of the co-occurrence of these two diseases.
Conclusion
This case suggested for the first time a potential genetic connection between idiopathic MN and sarcoidosis which needs further studies in the future.
A 2BS cell adapted China fixed rabies virus vaccine strain 2aG4-B40 and its application prospect in human rabies vaccine
Authors: Xu Ying , Weng Lin , Wang Xuan , Li Ming , Guo Wanping , Liu Yiqing , Li Xiang , Wang Zhenping , Liu Xinyu , Xu Shengnan , He Feide , Hou Qianqian , Li Tengzhou , Du Wenke , Zhang Yabo , Chang Shumin , Zhang Liwen , Zhang Yuntao 
Published: January 2024

Abstract
BACKGROUND
Rabies virus is a fatal zoonotic disease which the pathogenesis has not been fully elucidated, vaccination is the only effective method to protect against rabies virus infection. Most inactivated vaccines are produced using Vero cells (African green monkey kidney cells) for its large-scale productivity. However, there is a potential carcinogenic risk due to the non-human DNA contamination. Thus, replacing Vero cells with human diploid cells is a better solution. In this study, we invented a 2BS adapted rabies virus strain and analyzed its sequence, virulence and immunogenicity to prepare a new strain that may be used in the production of human diploid cell inactivated vaccine.
METHODS AND RESULTS
The human diploid adapted rabies virus strain 2aG4-B40 was established at the 40th generation by the combination of passage and pick spot in 2BS cells. The RNA sequence analysis showed that the mutations in 2BS adapted strains were not located on the key sites that affect the production of neutralizing antibodies and virulence compared to aG strain (GQ412744.1). The gradually increased virulence (remained above 7.0LogLD50/ml from the 40th to 55th generation) and antigen further indicated that these mutations may enhance the affinity of adapted strains to human diploid cells. Identification tests showed that the 2BS adaption virus strain was neutralized by anti-rabies serum with a neutralization index of 19952. PrEP and PEP vaccination and the NIH test further indicated that the vaccine prepared with the 2aG4-B40 strain had high levels of neutralizing antibody (2.24 to 46.67 IU/ml), immunogenicity (protection index 270) and potency (average 11.6 IU/ml).
CONCLUSIONS
In this study, 2BS adapted strain of 2aG4 rabies virus was obtained at the 40th generation. The results of sequencing analysis and titer determination of the adapted strains showed that, the mutations in the adaptive process are not located at key sequence regions of the virus, and these mutations may enhance the affinity of adapted strains to human diploid cells. Meanwhile, vaccines made from the adapted strain 2aG4-B40 had high potency and better immunogenicity, which could be an ideal candidate rabies virus strain for inactivated vaccines preparation.
Capturing the heterogeneity of the pancreatic ductal adenocarcinoma tumor microenvironment: novel triple co-culture spheroids for drug screening and angiogenic evaluation
Authors: Verloy Ruben , Privat-Maldonado Angela , Audenaerde Jonas Van , Rovers Sophie , Zaryouh Hannah , De Waele Jorrit , Deben Christophe , Smits Evelien , Bogaerts Annemie 
Published: January 2024

Abstract
Background Pancreatic ductal adenocarcinoma (PDAC) poses a significant health threat with poor response to current treatment options. The desmoplastic reaction, characteristic of PDAC, hinders therapeutic efficacy and emphasizes the need for novel in vitro models to study the complex tumor microenvironment and increase translatability. Three-dimensional in vitro co-culture models with clinically relevant numbers of cancer-associated fibroblasts and endothelial cells are still lacking and lead to failure of clinical trials and low improvement of patient survival.Methods MiaPaCa-2 and BxPC-3 cancer cell lines, RLT-PSC and hPSC21 pancreatic stellate cell lines and the endothelial cell line HMEC-1 were seeded in ultra-low-attachment round-bottomed plates to form triple co-culture spheroids. A growth assay including all cell lines was performed to evaluate if DMEM or MCDB131 is most ideal for spheroid formation and culturing. Multi-color flow cytometry was used to quantify cell populations after three days of spheroid formation to optimize the seeding ratios. Drug response profiles of mono-culture and triple co-culture spheroids were made using a cell viability assay. Finally, a tube formation assay with spheroid-conditioned medium was performed to showcase the potential of our model for angiogenic studies.Results We developed a panel of high-throughput triple co-culture spheroid models of pancreatic cancer cells, pancreatic stellate cells and endothelial cells. We were able to capture different facets of PDAC heterogeneity in scope of the tumor microenvironment using two different cancer and stellate cell lines, and one endothelial cell line. Importantly, drug responses varied between mono-culture and triple co-culture spheroids, underlining the impact of the tumor microenvironment, spatial arrangement, and spheroid density on therapeutic outcomes. Gemcitabine and paclitaxel treatments revealed different drug response profiles depending on the combination of BxPC-3 or MiaPaCa-2 with RLT-PSC or hPSC21 in a triple co-culture environment. A tube formation assay showcased the potential of our models to assess angiogenesis, providing a quantitative understanding of a treatment-induced response.Conclusions Our study brings sophisticated high-throughput in vitro models that are easy to reproduce and provide valuable insights into PDAC research to improve translatability and preclinical screening efficacy. In addition, our triple co-culture spheroids are cheap and include the heterogeneity of the PDAC tumor microenvironment.
Bilateral optic nerve infiltration and leukemic retinopathy as initial signs of leukemia relapse with central nervous system involvement in an adult: A case report
Authors: Wang Yisai , Zhu Ling , Wang Hongtao , Li Zhen , Bai Ruomeng , Wei Qinghua , Huang Lin , Xu Ying , Li Songguo , Chen Hui 
Published: January 2024

Abstract
Background:
We describe a case in which bilateral optic nerve infiltration and leukemic retinopathy were the initial signs of disease relapse in a patient with Philadelphia chromosome-positive acute lymphoblastic leukemia (Ph+-ALL) with central nervous system (CNS) involvement.
Case presentation:
A 65-year-old Asian female with Ph+-ALL in complete remission presented at our institution with symptoms of visual disturbance, central scotoma and pain with eye movement in both eyes for a 1-month duration. Ophthalmic examination revealed remarkable optic disc swelling with multiple flame-shaped peripapillary hemorrhages, retinal venous dilation and retinal hemorrhages in both eyes. She was subsequently referred to the treating oncologist and diagnosed with Ph+-ALL relapse with multiple relapsed diseases involving the bone marrow and CNS. After intrathecal (IT) therapy, her visual acuity dramatically improved, and her leukemic infiltrates decreased.
Conclusions:
To the best of our knowledge, this is the first case report of ALL relapse with CNS involvement presenting as bilateral optic nerve infiltration and leukemic retinopathy in an adult. Hence, we highlight the priority and sensitivity of ophthalmic examinations, as they are noninvasive methods for detecting leukemia relapse.
Aplastic anemia triggered by the Bruton tyrosine kinase inhibitor acalabrutinib in two patients with mantle cell lymphoma – a case report
Authors: Nikkarinen Anna , Glimelius Ingrid 
Published: January 2024

Abstract

The use of Bruton's tyrosine kinase inhibitors (BTKi) is rapidly increasing for patients with mantle cell lymphoma (MCL). Side effects reported so far are usually manageable and self-determining after dose-reduction or termination of the drug. However, here we present a new aspect of BTKi’s that needs to be taken into consideration as we report two cases of life-threatening aplastic anemia upon treatment with the BTKi acalabrutinib for MCL. The two patients were treated with acalabrutinib as first line treatment, patient 1 for a classical MCL with moderate proliferation and patient 2 for an aggressive tumor with blastoid morphology, p53 overexpression and high proliferation rate. Both patients had excellent tumor responses but within a few months they presented with trombocytopenia that quickly led to a fulminant pancytopenia. Acalabrutinib treatment was stopped immediately but the pancytopenia did not resolve. Investigations led to the diagnosis of the autoimmune disease aplastic anemia in both cases. Patient 1 died of neutropenic infection shortly after the diagnosis. Patient 2 was treated successfully with immunosuppression and regained near to normal blood counts, but subsequently developed relapsed MCL. Autoimmune diseases in general are overrepresented in patients with lymphoma, and there are reports of other autoimmune anemias such as autoimmune hemolytic anemia being triggered by lymphoma treatment. Aplastic anemia however, has never previously been reported as a potential side effect of BTKi in MCL. There is a possibility that this condition is underrecognized and mistaken for progression of tumor infiltration in the bone marrow. Aplastic anemia should be taken into consideration when patients present with pancytopenia during treatment with BTKi.
PyLST: A Python-based application for retrieving Land Surface Temperature from Landsat 5, 7, 8, &amp; 9
Authors: Parvar Zahra , Salmanmahiny Abdolrassoul 
Published: January 2024

Abstract
Land Surface Temperature (LST) can be used to understand the impacts of changes in Land Use and Land Cover (LULC) through remote sensing. This research introduces an open-access Python-based user interface for retrieving LST from Landsat images (Landsat 5, 7, 8 & 9) using multiple algorithms including Mono Window Algorithm (MWA), Radiative Transfer Equation (RTE) method, Single Channel Algorithm (SCA) and Split Window Algorithm (SWA). This software enables users to efficiently choose the most suitable algorithms by comparing different methods within their study area. A total of 24 Landsat images, comprising six images for each Landsat mission and encompassing various seasons, were employed to assess and compare the accuracy of the algorithms. All methods presented acceptable results, however, RTE provided slightly better results for Landsat 5 and Landsat 7 with a lower RMSE value. In Landsat 8 and 9, SWA had better results than the other algorithms (RMSE 2.1°C).
Comparison of the effectiveness of microneedling with topical insulin versus saline (as a placebo) in the treatment of striae Alba using Antera 3D camera. Controlled left-right comparative study
Authors: Abdallah Marwa , Ibrahim Samah , Ragab Aya , Elhawatky Ahmed 
Published: January 2024

Abstract
Background
Striae Alba is caused by overstretching of the skin's dermis with permanent structural alteration of collagen fibers and scaring of the dermis. Microneedling stimulates a cascade of growth factors by multiple cutaneous injuries, which stimulates the migration, and proliferation of fibroblasts with the synthesis of new collagen. Insulin is of interest in the field of wound repair and can help in restoring the integrity of damaged skin.
Objectives
Evaluation of the clinical response, efficacy, safety, and adverse effect of combined microneedling with topical insulin compared to microneedling alone (with saline as a placebo) in treating stria alba.
Subjects and methods:
In this controlled left/right comparative study, microneedling with saline (as a placebo) was done on the right side of the abdomen, while the left half of the microneedling was done using topical insulin. For each patient; we did four sessions with 1 month in-between. We evaluated the treatment outcome using photographic documentation and a 3D Antera camera and measured the decrease in the indentation index.
Results
A significant decrease was found in the stria-alba indentation index after treatment in both the insulin sides and placebo sides; the insulin side being superior. There was no statistical significant difference between them as regards the side effects like erythema and hyperpigmentation.
Conclusion
Microneedling with topical insulin is an effective and safe method for treating patients with striae alba.