bluuebunny/crossref_metadata_2025_split huggingface dataset:
BHSeP14 A UK centre experience of day case robotic hernia surgery
Authors: Robinson Paul , Glaysher Michael , Pucher Philip 
Published: January 2025

Abstract
We present our series of 82 robotic hernia repairs in a busy district general hospital over a two year period. Follow-up ranged from 5 to 24 months.
Between 01 January 2022 and 31 December 2023 we performed 35 robotic ventral hernia repairs (19 incisional midline, 3 spigelian and 13 umbilical). All hernias were repaired with closure of the defect and mesh reinforcement in either a retro-rectus or sublay plane. Mean operating time from knife to skin to final suture was 123 min (range 58–310 min). Mean length of stay was under 24 h with 60% (21/35) of cases being done as day case procedures. Mean width of defect was 4 cm (range 1–8 cm). Complications occurred in 14% (5/35) of patients with 2 recurrences, 2 haematomas and 1 seroma. One mesh was explanted during haematoma evacuation in the immediate postoperative period. There were no cases of surgical site infection.
Over the same time period we performed 47 robotic inguinal hernia repairs (35 unilateral, 12 bilateral). All were done via TAPP approach. Mean operating time was 73 min (range 49–113) for unilateral hernias and 111 min (range 67–146) for bilateral hernias. 75% (39/46) of cases were done as day surgery. Of the 7 patients admitted overnight 3 were planned admissions for social reasons. No patient stayed more than one night. Complications occurred in 4 patients; 3 patients went into urinary retention requiring catheterisation and 1 patient developed a seroma which was managed conservatively.
BHSeP16 Robotic groin hernia—a single centre experience on the learning curve
Authors: Hughes Niamh , Hughes Rebecca , Gilmore Katie , Pawlak Maciej 
Published: January 2025

Abstract

Background
Robotic transabdominal preperitoneal (rTAPP) repair is an advanced technique for managing groin hernias, offering enhanced surgical visualization and precision. Golden Jubilee National Hospital initiated a robotic hernia service in September 2023. This study reports outcomes and follow-up data for the first 43 patients undergoing rTAPP repair, focusing on the learning curve for a laparoscopically trained AWR consultant.

Methods
Data from the first 43 rTAPP repairs performed by a laparoscopically trained AWR consultant were analysed. This included demographics, operative and postoperative outcomes.

Results
The cohort included 43 male patients treated from October 2023 to May 2024, with a mean age of 44 years. Unilateral hernias accounted for 30%, while 70% were bilateral, with a mean BMI of 27.1; 16% were classified as obese and 14% were smokers. There were 42 primary repairs and one recurrent hernia. Hernia sizes, using EHS Inguino-Femoral Classification, were &lt;1.5 cm in 36%, 1.5–3 cm in 36%, and &gt;3 cm in 28%. The learning curve analysis showed a reduction in median surgery length by 9% for bilateral and 22% for unilateral repairs. Thirty-five procedures were day cases, four patients were discharged on the first postoperative day, and one required extended hospitalisation due to intraoperative bowel injury. One procedure was converted to open surgery, and one patient experienced a complication that resolved.

Conclusions
Robotic-assisted inguinal hernia surgery is a safe and effective alternative to traditional laparoscopic methods, offering improved visualization and precise dissection. The learning curve is notable, facilitating the transition to more complex procedures once mastered.
BHSeP38 Hernia assessment & management pathway
Authors: Bhagtani Priyanka , Momin Erbaz 
Published: January 2025

Abstract
The new millennium has brought in so much rapid advancements to the field of hernia that not just surgeons in practice but even training institutes are struggling to keep pace. General Surgeons who primarily have been managing this condition would find it difficult to negotiate the maze of newer terminologies, techniques or complex situations & may end up with less favourable outcomes.
In the current state of chaos a training program is acutely needed to empower young surgeons to make better decisions for best outcomes. With these objectives; targeting trainees to surgeons in practice; We have designed a course to streamline the thought process in approaching a hernia patient.
It is a comprehensive course encompassing classifications to complications and special scenarios as well. Specific learning objectives defined for each of the topics are in the knowledge and communication domain. Hence the course has been designed around faculty led small group discussions enabling personalised attention to each participant to modulate and enhance their decision making.
Unlike other courses it does not restrict to one specific approach or technique but focusses on the entire speciality. The participants are shared reference material to prepare for the course. A pre-test & a post test is conducted to assess the impact of the course.
We intend to bring about a positive change by empowering young surgeons to make better decisions which may improve hernia outcomes in the future. We would like to share our experience based on training 50 delegates in multiple sessions.
BHSeP39 Incidence of additional defects identified during minimally invasive complex abdominal wall reconstruction not demonstrated on pre-operative CT imaging
Authors: Ward Thomas , Al-Amiedy Zaid , Sharma Amit , Walsh Ciaran , Simpson Gregory 
Published: January 2025

Abstract

Introduction
Hernia recurrence after repair remains a significant issue after all types of abdominal wall hernia operations. Some reports suggest recti diastasis is a risk factor for hernia recurrence unless concomitantly repaired. With the use of minimally invasive techniques (MIS) (laparoscopic or robotic), both ventral hernias and recti diastasis can be surgically repaired simultaneously. We audited the rate of incidental intra-operative ventral defects related to diastatic linea alba in patients with ventral hernias and pre-operative evidence of recti diastasis.

Methods
A retrospective analysis was performed of a prospectively maintained database of all cases of MIS abdominal wall reconstructions. We analysed the rate of additional ventral hernia defects that were undetected on pre- operative CT imaging.

Results
36 patients who underwent eTEP Rives-Stoppas repair were included (30 robotic, 6 laparoscopic). Male to female ratio was 27:9. Median age 58 years, median BMI 29.9. Of 36 cases 44.4% (16) had extra defects identified at the time of surgery, compared to the pre-operative imaging.

Conclusion
Minimally invasive abdominal wall reconstruction provides a unique view of the bare underside of the linea alba, allowing all defects to be seen accurately. Extra defects, not seen on pre-op imaging are common. The presence of such occult defects could be a mechanism for recurrence in local hernia repairs. This finding could strengthen the case for a more extensive repair, eg: rives stoppa, in patients with ventral hernias within diastasis recti.
BHSeP40 Robotic complex abdominal wall reconstruction is safe and cost-effective: analysis of introduction of robotic AWR to an NHS practice
Authors: Ward Thomas , Al-Amiedy Zaid , Sharma Amit , Walsh Ciaran , Simpson Gregory 
Published: January 2025

Abstract

Introduction
Robotic assisted surgery is the latest advance in minimally invasive surgery, combining abdominal wall reconstruction and restoration of functional anatomy with reduced wound morbidity and recovery time. The aim of this article is to review the cost of robotic (rAWR) vs open abdominal wall reconstruction (oAWR), for complex hernias.

Method
We reviewed a prospective database of all AWR conducted since the start of performing rAWR. We collected data from the electronic patient record including demographics, theatre times, length of stay, length of planned/unplanned admission to HDU, ASA, Charleson-comorbidity index, primary vs recurrent hernia repair, complications, and mortality. All patients were followed-up for 30days post-op via the electronic record for complications and re-admissions.

Results
We collected data of 46 cases (28 robotic, 18 open). Median LOS was rAWR 1.5 days, oAWR 6.5 days. There were no incidences of mortality in either group in the 30 days of follow-up. There was one incidence of conversion to open from rAWR. For our cohort, the rAWR was £2123.14 cheaper per case than oAWR. This is due to savings in length of stay, reduced PCA usage, shorter and less complex anaesthesia. This per-procedure saving represents a significant cost saving, helping to offset the cost of the robotic system.

Conclusion
This is real-world data of the successful introduction of complex robotic AWR to NHS practice. Robotic cAWR is safe and cost saving and significantly reduces length of stay.
BHSeP41 The use of Phasix™ bioresorbable mesh with posterior component separation for complex abdominal wall reconstruction: 3 year series
Authors: Snashall Emma , Rajaretnam Niroshini , Scott Michael , West Chris 
Published: January 2025

Abstract

Phasix™ biosynthetic mesh, manufactured from a biologically-derived absorbable polymer Poly-4-hydroxybutyrate (P4HB), comprises a monofilament scaffold that allows tissue ingrowth and is fully resorbed by hydrolysis in 12–18 months. Advantages include maintaining the tensile strength of a synthetic mesh whilst addressing the favourable properties of remodelling of a biological mesh.
We report our 3 year follow-up outcome data for this mesh in Abdominal Wall Reconstruction (AWR) at the largest UK AWR centre.

Method
5 year retrospective analysis (2016–2021) of consecutive AWR procedures performed using Phasix™ mesh, with minimum 3-year follow up period. Patients identified from electronic records. Standardised procedure involved radical skin excision, extraperitoneal posterior component separation (Rives-Stoppa [RS] or transversus abdominis release [TAR]) and sublay mesh placement. All patients operated jointly by a single plastic and general surgery consultant pair.

Results
206 reconstructive procedures performed using Phasix TM mesh in patients with a male:female ratio of 1.6:1, mean age 53 (range 27–86) and mean BMI 30.9 (16.9–55.4). RS technique used in 81% with 19% requiring TAR. Mean LOS was 4.75 days (SD 3.6). Wound complications reported in 12.6% (n = 26) and seroma rate 6.8% (n = 14), both significantly associated with obesity (OR 6.6, P &lt; 0.09 and OR 6.3, P &lt; 0.02 respectively). Venous thromboembolism reported in 2% (n = 4), respiratory complications in 9% (n = 19) and ileus in 1.9% (n = 4). Hernia recurrence 1.9% (n = 4). Mortality in 1 patient (BMI 44, ASA 3).

Conclusion
Our data supports the safe use of biosynthetic mesh in AWR with a low recurrence rate and acceptable complication rate.
Copper in colorectal cancer patients: a systematic review and meta-analysis
Authors: Muñoz-Bravo Carlos , Marín-Burdallo Inés , González-Herrera Lucas , González-Palacios Torres Carla , Lozano-Lorca Macarena , Jiménez-Moleón José Juan , Olmedo-Requena Rocío 
Published: January 2025

Abstract
Several clinical studies have evaluated the relationship between copper on colorectal cancer (CRC), but the results are contradictory. This study aimed to conduct a systematic review and meta-analysis to investigate copper measured in two biological matrices (serum/plasma/blood and tissue) and dietary intake in CRC patients compared to healthy controls. We conducted a comprehensive and systematic search in PubMed, Scopus, Embase, and Web of Science. We included studies that reported copper levels in serum/plasma/blood, tissue, or from the diet, with an observational study design (cohort and case–control studies). Study quality was assessed with the Newcastle–Ottawa scale and potential causes of heterogeneity were evaluated. Standardized mean differences (SMD) with 95% confidence interval (CI) were pooled using random-effect models. Overall pooled odds ratio and 95% CI for the risk of CRC were calculated. Twenty-six studies (23 case–control and 3 cohort studies) with a total of 227 354 participants were included. Most of the studies presented low (50%) or moderate quality (42.3%). No differences in serum/plasma/blood copper levels (SMD = 0.23; 95% CI: −0.23, 0.70; I2 = 97.3%, 19 studies), tissue copper levels (SMD = −1.69; 95% CI: −3.41, 0.03; I2 = 85.6%, 2 studies), or copper/zinc ratio (SMD = 1.19; 95% CI: 0.54, 1.84; I2 = 95.3%, 6 studies) were found between CRC patients and healthy controls. Regarding dietary copper, CRC patients had a lower intake (SMD = −0.27; 95% CI: −0.51, −0.03; I2 = 0.0%, 2 studies). No differences were found in copper levels between CRC patients and healthy controls. However, evidence shows mostly low or moderate quality, and results were heterogeneous. More prospective studies with an adequate methodological approach are needed.
Quantum chemically calculated Abraham parameters for quantifying and predicting polymer hydrophobicity
Authors: Hickey Kevin P , MacDonell Margaret M , Picel Kurt C 
Published: January 2025

Abstract
The leakage and accumulation of plastic in the environment is a significant and growing problem with numerous detrimental impacts and has led to a push toward the design and development of more environmentally benign materials. To this end, we have developed a quantum chemistry-based model for predicting the mobility of polymer materials from molecular structure. Hydrophobicity is used as a surrogate for mobility given that hydrophobic interactions drive much of the partitioning of contaminants in and out of various environmentally relevant compartments. To model polymer hydrophobicity, we adjusted a previously developed Quantum Chemically Calculated Abraham Parameter model to calculate Abraham parameters of small molecules from molecular structure information. The resulting model predicted the octanol-water partition coefficient (KOW) of polymer repeating units with a root mean square error (RMSE) of 0.48 (log scale). Additionally, the hydrophobicity of high molecular weight polymer materials was captured through solubility parameters and Nile red staining experiments from the literature and predicted with RMSEs of 1.21 (J/cc)0.5 and 3.42 nm, respectively. Finally, to test the environmental applicability of the model, the relative adsorption capacity of three polymers was predicted and used to unify sorption isotherms across multiple sorbates and polymer sorbents.
Influences of gonad developmental stage on ovary selenium concentrations in fish—implications for ovary selenium monitoring
Authors: Brix Kevin V , Tear Lucinda M , Elphick James , Ings Jennifer , Detering Claire , Carr Meghan , Raes Katherine , Arnold Mariah C , Adzic Marko , Hecker Markus , de Bruyn Adrian , DeForest David K 
Published: January 2025

Abstract
Monitoring selenium (Se) concentrations in fish ovaries is an important tool for evaluating the ecological risk posed by Se in aquatic systems. Most guidance recommends sampling fish ovaries as closely as possible to when fish spawn on the premise that Se is mobilized from the liver to the ovary during vitellogenesis, and therefore, sampling ovaries during the early phases of oocyte maturation may underestimate egg Se concentrations at the time of spawning. In this study, we evaluated ovary Se data from two species with synchronous oocyte development (Ptychocheilus oregonensis and Prosopium williamsoni), one species with asynchronous oocyte development (Richardsonius balteatus), and one where the mode of development is unclear (Mylocheilus caurinus). A multivariate analysis of ovary Se as a function of fish sampling location, size, and gonado-somatic index (GSI) demonstrated ovary Se was strongly negatively correlated with GSI in fish species with synchronous oocyte development but only weakly correlated in a species with asynchronous development. In R. balteatus, a relationship between expressible (released) egg Se and remaining ovary Se was observed, with egg concentrations ∼54% of ovary concentrations on average. Overall, our findings suggest that current understanding of the mechanisms by which Se is maternally transferred to oocytes is not entirely correct and raises questions regarding how and when during the reproductive cycle Se is mobilized to ovaries. Further, our findings have significant implications for interpretation of ovary Se monitoring data collected from unripe fish. We developed regression-based models to correct ovary Se data that are biased by sampling females not in spawning condition and demonstrate how this bias can impact evaluation of Se risk to fish.
Diversity and ‘successful ageing’: exploring intersectional and existential dimensions to ageing well
Authors: Pickard Susan , Cluley Victoria , Sharma Surinder , Oli Upanish , Thomas-Ekweh Gifty , Banerjee Jay , Williams Chris , Conroy Simon , Vanhoutte Bram , Labeit Alex 
Published: January 2025

Abstract

Background and objectives
This paper aims to add to the literature on successful ageing in minoritized ethnic groups. Concurring with the critiques of ‘successful ageing’ for focusing on values and abilities more attainable by white middle-class older people, it explores alternative discourses according to which older people from minoritized groups consider themselves to be ‘ageing well’.

Research design and methods
The paper draws on original empirical material derived from a longitudinal research project focused on five minority ethnic groups living in a city (and surrounding areas) of the UK known for its diverse population. It draws on photovoice methods conducted with the participants and analyses the material through (i) a focus on intersectionality as a framing device that is dynamic over time and (ii) phenomenological approaches to old age as a distinct life stage existentially.

Results
Although intersectionality is framed in the literature almost exclusively in terms of disadvantage, older participants made use of assets as well as deficits (which they often turned into assets) to construct a sense of meaning and purpose that enabled them to age well and flourish in often challenging circumstances.

Discussion and implications
The images and narratives presented here challenge the normative depictions of a good or successful old age constructed from the perspective of white and middle-class older adults. They add a diverse range of alternative depictions of ageing well which will be of help for clinicians and others in supporting diverse older people to flourish in conditions of health as well as frailty.
Numerical analysis of a spherical harmonic discontinuous Galerkin method for scaled radiative transfer equations with isotropic scattering
Authors: Sheng Qiwei , Hauck Cory D , Xing Yulong 
Published: January 2025

Abstract
In highly diffusion regimes when the mean free path $\varepsilon $ tends to zero, the radiative transfer equation has an asymptotic behavior which is governed by a diffusion equation and the corresponding boundary condition. Generally, a numerical scheme for solving this problem has the truncation error containing an $\varepsilon ^{-1}$ contribution that leads to a nonuniform convergence for small $\varepsilon $. Such phenomenons require high resolutions of discretizations, which degrades the performance of the numerical scheme in the diffusion limit. In this paper, we first provide a priori estimates for the scaled spherical harmonic ($P_{N}$) radiative transfer equation. Then we present an error analysis for the spherical harmonic discontinuous Galerkin (DG) method of the scaled radiative transfer equation showing that, under some additional assumptions, its solutions converge uniformly in $\varepsilon $ to the solution of the scaled radiative transfer equation. We further present an optimal convergence result for the DG method with the upwind flux on Cartesian grids. Error estimates of $\left (1+\mathcal{O}(\varepsilon )\right )h^{k+1}$ (where $h$ is the maximum element length) are obtained when tensor product polynomials of degree at most $k$ are used.
Prion protein modulation of virus-specific T cell differentiation and function during acute viral infection
Authors: Viramontes Karla M , Thone Melissa N , DeRogatis Julia M , Neubert Emily N , Henriquez Monique L , De La Torre Jamie-Jean , Tinoco Roberto 
Published: January 2025

Abstract
The differentiation and functionality of virus-specific T cells during acute viral infections are crucial for establishing long-term protective immunity. While numerous molecular regulators impacting T cell responses have been uncovered, the role of cellular prion proteins (PrPc) remains underexplored. Here, we investigated the impact of PrPc deficiency on the differentiation and function of virus-specific T cells using the lymphocytic choriomeningitis virus (LCMV) Armstrong acute infection model. Our findings reveal that Prnp–/– mice exhibit a robust expansion of virus-specific CD8+ T cells, with similar activation profiles as wild-type mice during the early stages of infection. However, Prnp–/– mice had higher frequencies and numbers of virus-specific memory CD8+ T cells, along with altered differentiation profiles characterized by increased central and effector memory subsets. Despite similar proliferation rates early during infection, Prnp–/– memory CD8+ T cells had decreased proliferation compared with their wild-type counterparts. Additionally, Prnp–/– mice had higher numbers of cytokine-producing memory CD8+ T cells, indicating a more robust functional response. Furthermore, Prnp–/– mice had increased virus-specific CD4+ T cell responses, suggesting a broader impact of PrPc deficiency on T cell immunity. These results unveil a previously unrecognized role for PrPc in regulating the differentiation, proliferation, and functionality of virus-specific T cells, providing valuable insights into immune system regulation by prion proteins during viral infections.
Reduced autoimmunity associated with deletion of host CD73
Authors: Okeugo Beanna , Armbrister Shabba A , Daniel Rhea C , Saleh Zeina M , Wang Jessica , Giorgberidze Salomea , Rhoads J Marc , Liu Yuying 
Published: January 2025

Abstract
CD73 is ubiquitously expressed and regulates critical functions across multiple organ systems. The sequential actions of CD39 and CD73 accomplish the conversion of adenosine triphosphate to adenosine and shift the adenosine triphosphate–driven proinflammatory immune cell milieu toward an anti-inflammatory state. This immunological switch is a major mechanism by which regulatory T (Treg) cells control inflammation. Foxp3 engages in Treg development and function. Foxp3 mutations result in the scurfy (SF) mouse phenotype and a rapidly lethal lymphoproliferative syndrome. We generated double knockout (KO) mouse (CD73KOSF) by breeding heterozygous Foxp3sf/J females to CD73KO male mice to remove host CD73. We initially aimed to use these mice to identify a specific probiotic-CD73 effect, previously shown for Limosilactobacillus reuteri DSM 17938. We expected CD73 deletion to enhance the severity of autoimmunity in SF mice. However, we unexpectedly observed that KO of host CD73 in SF mice clinically reduced the severity of autoimmunity including reduced ear thickness, increased ear size, and less deformed ears, along with less dry and brittle skin. KO of CD73 in SF mice significantly reduced the numbers of CD4+ and CD8+T cells in spleen and blood. We identified that KO of CD73 in SF mice reduced the numbers of T cells in the thymus compared with those in SF mice, indicating that the milder clinical phenotype may be due to reduced central and peripheral lymphoproliferation. These new findings suggest targeting CD73 could improve T cell–mediated dermatitis, one of the most common symptoms in Treg deficiency–associated primary immune deficiencies.
On Derivatives of Kato’s Euler System and the Mazur-Tate Conjecture
Authors: Burns David , Kurihara Masato , Sano Takamichi 
Published: January 2025

Abstract
We provide a new interpretation of the Mazur-Tate Conjecture and then use it to obtain the first (unconditional) theoretical evidence in support of the conjecture for elliptic curves of strictly positive rank.