bluuebunny/crossref_metadata_2025_split huggingface dataset:
CBT for post-traumatic stress disorder and depression in the context of pregnancy loss: a case study reflection
Authors: Hassan Hibah , Holmes Natalie 
Published: November 2023

Abstract
Women who experience pregnancy loss are at increased risk of psychological distress, including post-traumatic stress disorder (PTSD) and depression. Despite the substantial evidence base for trauma-focused cognitive behavioural therapy (CBT) for PTSD, there is limited research on this specific type of trauma, as well as a dearth of research exploring treatment for co-morbid PTSD and depression. This study used a single case experimental design to assess the efficacy of sequential CBT for treating PTSD and depression in a primary care setting in the United Kingdom. Results demonstrate a reduction in scores on the PCL-5 following trauma-focused CBT, but not a clinically significant reduction in depression scores. This write-up reflects on the effectiveness of sequential treatment and suggests alternative approaches. Future directions for research are also given.
Dedication: The authors dedicate this paper to all parents who have experienced pregnancy or baby loss.

Key learning aims

(1)
To gain an understanding of some of the challenges in delivering CBT for trauma related to pregnancy loss.

(2)
To reflect on treatment of co-morbid PTSD and depression through flexible use of evidence-based treatment, and consider alternative approaches to sequential treatment.

(3)
To consider the impact of grief in formulation and treatment.
The impact of smoking and nicotine exposure during pregnancy on fetal nephrogenesis: a systematic review
Authors: Popham Kelsey , Kandasamy Yogavijayan 
Published: November 2023

AbstractThe effect of smoking and nicotine exposure during pregnancy on fetal nephrogenesis is a growing area of research. The objective of this systematic review is to summarise the current evidence in this research field. Our literature search identified a total of 415 articles from PubMed, Embase, Scopus, and Cochrane. After electronic sorting and manual screening, 18 eligible articles were found, 6 being human studies and 12 being animal studies. Articles that did not study nicotine or smoking, did not focus on fetal kidney development, or did not include nicotine or smoking exposure during pregnancy were excluded from the systematic review. The main outcomes of the studies were kidney weight, volume and size, kidney histopathology and morphology, and kidney function. Evidence from human studies identified a reduction in fetal kidney size, volume, and weight in offspring exposed to smoking during pregnancy; and the greatest impact was seen in offspring exposed to >5–10 cigarettes per day. Animal studies investigated kidney histopathology and highlighted kidney injury and microscopic changes in response to nicotine exposure during pregnancy. Further research is required to determine the impact on kidney function. Recreational nicotine use is evolving, and with the increasing use of urine cotinine in the evaluation of nicotine exposure, further research is needed.
The Repetition Period of MeV Electron Microbursts as Measured by SAMPEX/HILT
Authors: Kandar Hamdan , Blum Lauren , Shumko Mykhaylo , Chen Lunjin , Shue Jih‐Hong 
Published: November 2023

AbstractHere we examine properties of MeV electron microbursts to better understand their generation mechanisms. Using 15 years of data from Solar, Anomalous, Magnetospheric Particles Explorer/Heavy Ion Large Telescope, >1 MeV microburst repetition periods (time spacing between bursts) are examined and clear dependencies on Auroral Electrojet (AE), L shell, and magnetic local time (MLT) are discovered. Microburst repetition periods are shortest around 0–6 hr MLT and 4–5 L shell, and grow longer toward the day and afternoon sectors and larger L shells. Shorter repetition periods (<1 s) are also found to be more common during higher AE, while longer periods (>10 s) more common during quiet times. The microburst repetition period distributions are compared directly to those of rising tone chorus wave elements and found to be similar in the night, dawn and day MLT sectors, suggesting chorus wave repetition periods are likely directly controlling those of microburst precipitation. However, dusk‐side distributions differ, indicating that the dusk‐side microbursts properties may be controlled by other processes.
The Attenuation and Scattering Signature of Fluid Reservoirs and Tectonic Interactions in the Central‐Southern Apennines (Italy)
Authors: Talone D. , De Siena L. , Lavecchia G. , de Nardis R. 
Published: November 2023

AbstractDespite the high detection level of the Italian seismic network and the risk associated with its fault networks, Central‐Southern Italy has no unique geophysical model of the crust able to illuminate its complex tectonics. Here, we obtain seismic attenuation and scattering tomography models of this area; both reveal high attenuation and scattering anomalies characterizing the entire Apenninic Chain and related to its East‐ and West‐dipping extensional Quaternary tectonic alignments. Fault‐associated fractured zones become preferential ways for circulating and degassing high‐attenuation CO2‐bearing fluids. A previously undetected fluid source area is a high‐attenuation volume below the Matese complex, while a similar smaller anomaly supports a fluid source near L'Aquila. The most prominent low attenuation and scattering volumes reveal a locked aseismic zone corresponding to the Fucino‐Morrone‐Porrara fault systems, representing a zone of significant seismic hazard.
Fine and Coarse Dust Effects on Radiative Forcing, Mass Deposition, and Solar Devices Over the Middle East
Authors: Mostamandi Suleiman , Ukhov Alexander , Engelbrecht Johann , Shevchenko Illia , Osipov Sergey , Stenchikov Georgiy 
Published: November 2023

AbstractIn desert regions like the Middle East, dust has a profound impact on the environment, climate, air quality, and solar devices. The size of dust particles determines the extent of these effects. Dust deposition (DD) measurements show that coarse dust particles with geometric radius r > 10 μm comprise most of the deposited mass. Still, these particles are not represented in the current models that are tuned to fit the observed aerosol optical depth (AOD). As a result, the existing models and reanalysis products underestimate DD and dust emission (DE) almost 3 times. This is the first study to constrain the dust simulations by both AOD and DD measurements to quantify the effect of coarse and fine dust using the WRF‐Chem model. We found that, on average, coarse dust contributes less than 10% to dust shortwave radiative forcing (RF) at the surface but comprises more than 70% of DE. Annual mean net RF over the Arabian Peninsula and regional seas locally reaches −25 W m−2. Airborne fine dust particles with radii r < 3 μm are mainly responsible for the significant dimming (5%–10%) of solar radiation, cooling the surface, and hampering solar energy production. However, dust mass deposition is primarily linked to coarse particles, decreasing the efficiency of photovoltaic panels by 2%–5% per day. Therefore, incorporating coarse dust in model simulations and data assimilation would improve the overall description of the dust mass balance and its impact on environmental systems and solar devices.
Perspectives of current understanding and therapeutics of Diamond-Blackfan anemia
Authors: Liu Yang , Karlsson Stefan 
Published: November 2023

AbstactDiamond-Blackfan anemia (DBA) is a rare congenital bone marrow failure disorder characterized by erythroid hypoplasia. It primarily affects infants and is often caused by heterozygous allelic variations in ribosomal protein (RP) genes. Recent studies also indicated that non-RP genes like GATA1, TSR2, are associated with DBA. P53 activation, translational dysfunction, inflammation, imbalanced globin/heme synthesis, and autophagy dysregulation were shown to contribute to disrupted erythropoiesis and impaired red blood cell production. The main therapeutic option for DBA patients is corticosteroids. However, half of these patients become non-responsive to corticosteroid therapy over prolonged treatment and have to be given blood transfusions. Hematopoietic stem cell transplantation is currently the sole curative option, however, the treatment is limited by the availability of suitable donors and the potential for serious immunological complications. Recent advances in gene therapy using lentiviral vectors have shown promise in treating RPS19-deficient DBA by promoting normal hematopoiesis. With deepening insights into the molecular framework of DBA, emerging therapies like gene therapy hold promise for providing curative solutions and advancing comprehension of the underlying disease mechanisms.
Effectiveness of pre-pregnancy lifestyle in preventing gestational diabetes mellitus—a systematic review and meta-analysis of 257,876 pregnancies
Authors: Sampathkumar Swetha , Parkhi Durga , Ghebremichael-Weldeselassie Yonas , Sukumar Nithya , Saravanan Ponnusamy 
Published: November 2023

Abstract
Background
Gestational Diabetes Mellitus (GDM) is hyperglycaemia first detected during pregnancy. Globally, GDM affects around 1 in 6 live births (up to 1 in 4 in low- and middle-income countries- LMICs), thus, urgent measures are needed to prevent this public health threat.

Objective
To determine the effectiveness of pre-pregnancy lifestyle in preventing GDM.

Methods
We searched MEDLINE, Web of science, Embase and Cochrane central register of controlled trials. Randomized control trials (RCTs), case-control studies, and cohort studies that assessed the effect of pre-pregnancy lifestyle (diet and/or physical activity based) in preventing GDM were included. Random effects model was used to calculate odds ratio (OR) with 95% confidence interval. The Cochrane ROB-2 and the Newcastle-Ottawa Scale were used for assessing the risk of bias. The protocol was registered in PROSPERO (ID: CRD42020189574)

Results
Database search identified 7935 studies, of which 30 studies with 257,876 pregnancies were included. Meta-analysis of the RCTs (N = 5; n = 2471) in women who received pre-pregnancy lifestyle intervention showed non-significant reduction of the risk of developing GDM (OR 0.76, 95% CI: 0.50–1.17, p = 0.21). Meta-analysis of cohort studies showed that women who were physically active pre-pregnancy (N = 4; n = 23263), those who followed a low carbohydrate/low sugar diet (N = 4; n = 25739) and those women with higher quality diet scores were 29%, 14% and 28% less likely to develop GDM respectively (OR 0.71, 95% CI: 0.57, 0.88, p = 0.002, OR 0.86, 95% CI: 0.68, 1.09, p = 0.22 and OR 0.72, 95% CI 0.60–0.87, p = 0.0006).

Conclusion
This study highlights that some components of pre-pregnancy lifestyle interventions/exposures such as diet/physical activity-based preparation/counseling, intake of vegetables, fruits, low carbohydrate/low sugar diet, higher quality diet scores and high physical activity can reduce the risk of developing gestational diabetes. Evidence from RCTs globally and the number of studies in LMICs are limited, highlighting the need for carefully designed RCTs that combine the different aspects of the lifestyle and are personalized to achieve better clinical and cost effectiveness.
NF-κB signaling activation and roles in thyroid cancers: implication of MAP3K14/NIK
Authors: Cormier Françoise , Housni Selma , Dumont Florent , Villard Mélodie , Cochand-Priollet Béatrix , Mercier-Nomé Françoise , Perlemoine Karine , Bertherat Jérôme , Groussin Lionel 
Published: November 2023

AbstractAmong follicular-derived thyroid cancers (TC), those with aggressive behavior and resistance to current treatments display poor prognosis. NF-κB signaling pathways are involved in tumor progression of various cancers. Here, we finely characterize the NF-κB pathways and their involvement in TC. By using immunoblot and gel shift assays, we demonstrated that both classical and alternative NF-κB pathways are activated in ten TC-derived cell lines, leading to activated RelA/p50 and RelB/p50 NF-κB dimers. By analyzing the RNAseq data of the large papillary thyroid carcinoma (PTC) cohort from The Cancer Genome Atlas (TCGA) project, we identified a tumor progression-related NF-κB signature in BRAFV600E mutated-PTCs. That corroborated with the role of RelA and RelB in cell migration and invasion processes that we demonstrated specifically in BRAFV600E mutated-cell lines, together with their role in the control of expression of genes implicated in invasiveness (MMP1, PLAU, LCN2 and LGALS3). We also identified NF-κB-inducing kinase (NIK) as a novel actor of the constitutive activation of the NF-κB pathways in TC-derived cell lines. Finally, its implication in invasiveness and its overexpression in PTC samples make NIK a potential therapeutic target for advanced TC treatment.
Accuracy of HPV E6/E7 oncoprotein tests to detect high-grade cervical lesions: a systematic literature review and meta-analysis
Authors: Downham Laura , Jaafar Iman , Rol Mary Luz , Nyawira Nyaga Victoria , Valls Joan , Baena Armando , Zhang Li , Gunter Marc J. , Arbyn Marc , Almonte Maribel 
Published: November 2023

Abstract
Background
Cervical carcinogenesis is mediated by the HPV-E6 and E7 oncoproteins, considered as biomarkers usable in managing screen-positive women.

Methods
We conducted a systematic review and meta-analysis assessing the accuracy of HPV-E6/E7-oncoprotein tests to detect underlying cervical-precancer and cancer. We included studies reporting data on oncoprotein test accuracy detecting cervical intraepithelial neoplasia grade 3 or worse. Random effects logistic regression models were applied for pooling absolute and relative accuracy.

Results
Twenty-two studies were included. Sensitivity and specificity estimates ranged from 54.2% (95%CI: 45.2–63.0) to 69.5% (95%CI:60.8–76.9) and from 82.8% (95%CI: 50.4–95.8) to 99.1 (95%CI: 98.8–99.3), respectively in the population irrespective of HPV status. Higher sensitivity estimates ranging from 60.8% (95%CI: 49.6–70.9) to 75.5% (95%CI: 71.7–78.9) but lower specificity estimates ranging from 83.7% (95%CI: 76.1–89.3) to 92.1% (95%CI: 88.5–94.6) were observed in studies enrolling high-risk-HPV-positive women. Studies recruiting only HIV-positive women showed a pooled sensitivity of 46.9% (95%CI: 30.6–63.9) with a specificity of 98.0% (95%CI: 96.8–98.7).

Conclusions
The high specificity of oncoprotein tests supports its use for triaging HPV-positive women. However, oncoprotein-negative women would not be recommended to undertake routine screening, requiring further follow-up. Large-scale and longitudinal studies are needed to further investigate the role of E6/E7-oncoprotein detection in predicting the risk of developing cervical pre-cancer and cancer.
Circulating tumour cells and PD-L1-positive small extracellular vesicles: the liquid biopsy combination for prognostic information in patients with metastatic non-small cell lung cancer
Authors: Eslami-S Zahra , Cortés-Hernández Luis Enrique , Sinoquet Léa , Gauthier Ludovic , Vautrot Valentin , Cayrefourcq Laure , Avoscan Laure , Jacot William , Pouderoux Stéphane , Viala Marie , Thomas Quentin Dominique , Lamy Pierre-Jean , Quantin Xavier , Gobbo Jessica , Alix-Panabières Catherine 
Published: November 2023

Abstract
Background
Circulating tumour cells (CTCs), circulating tumour DNA (ctDNA), and extracellular vesicles (EVs) are minimally invasive liquid biopsy biomarkers. This study investigated whether they predict prognosis, alone or in combination, in heterogenous unbiased non-small cell lung cancer (NSCLC) patients.

Methods
Plasma samples of 54 advanced NSCLC patients from a prospective clinical trial. CtDNA mutations were identified using the UltraSEEK™ Lung Panel (MassARRAY® technology). PD-L1 expression was assessed in small EVs (sEVs) using an enzyme-linked immunosorbent assay.

Results
At least one ctDNA mutation was detected in 37% of patients. Mutations were not correlated with overall survival (OS) (HR = 1.1, 95% CI = 0.55; 1.83, P = 0.980) and progression-free survival (PFS) (HR = 1.00, 95% CI = 0.57–1.76, P = 0.991). High PD-L1+ sEV concentration was correlated with OS (HR = 1.14, 95% CI = 1.03–1.26, P = 0.016), but not with PFS (HR = 1.08, 95% CI = 0.99–1.18, P = 0.095). The interaction analysis suggested that PD-L1+ sEV correlation with PFS changed in function of CTC presence/absence (P interaction = 0.036). The combination analysis highlighted worse prognosis for patients with CTCs and high PD-L1+ sEV concentration (HR = 7.65, 95% CI = 3.11–18.83, P < 0.001). The mutational statuses of ctDNA and tumour tissue were significantly correlated (P = 0.0001).

Conclusion
CTCs and high PD-L1+ sEV concentration correlated with PFS and OS, but not ctDNA mutations. Their combined analysis may help to identify patients with worse OS.

Trial registration
NCT02866149, Registered 01 June 2015, https://clinicaltrials.gov/ct2/show/study/NCT02866149.
Online conversion of reconstructed neural morphologies into standardized SWC format
Authors: Mehta Ketan , Ljungquist Bengt , Ogden James , Nanda Sumit , Ascoli Ruben G. , Ng Lydia , Ascoli Giorgio A. 
Published: November 2023

AbstractDigital reconstructions provide an accurate and reliable way to store, share, model, quantify, and analyze neural morphology. Continuous advances in cellular labeling, tissue processing, microscopic imaging, and automated tracing catalyzed a proliferation of software applications to reconstruct neural morphology. These computer programs typically encode the data in custom file formats. The resulting format heterogeneity severely hampers the interoperability and reusability of these valuable data. Among these many alternatives, the SWC file format has emerged as a popular community choice, coalescing a rich ecosystem of related neuroinformatics resources for tracing, visualization, analysis, and simulation. This report presents a standardized specification of the SWC file format. In addition, we introduce xyz2swc, a free online service that converts all 26 reconstruction formats (and 72 variations) described in the scientific literature into the SWC standard. The xyz2swc service is available open source through a user-friendly browser interface (https://neuromorpho.org/xyz2swc/ui/) and an Application Programming Interface (API).
Phase biasing of a Josephson junction using Rashba–Edelstein effect
Authors: Senapati Tapas , Karnad Ashwin Kumar , Senapati Kartik 
Published: November 2023

AbstractA charge-current-induced shift in the spin-locked Fermi surface leads to a non-equilibrium spin density at a Rashba interface, commonly known as the Rashba–Edelstein effect. Since this is an intrinsically interfacial property, direct detection of the spin moment is difficult. Here we demonstrate that a planar Josephson Junction, realized by placing two closely spaced superconducting electrodes over a Rashba interface, allows for a direct detection of the spin moment as an additional phase in the junction. Asymmetric Fraunhofer patterns obtained for Nb-(Pt/Cu)-Nb nano-junctions, due to the locking of Rashba–Edelstein spin moment to the flux quantum in the junction, provide clear signatures of this effect. This simple experiment offers a fresh perspective on direct detection of spin polarization induced by various spin-orbit effects. In addition, this platform also offers a magnetic-field-controlled phase biasing mechanism in conjunction with the Rashba–Edelstein spin-orbit effect for superconducting quantum circuits.
Inconsistent shifts in warming and temperature variability are linked to reduced avian fitness
Authors: Taff Conor C. , Shipley J. Ryan. 
Published: November 2023

AbstractAs the climate has warmed, many birds have advanced their breeding timing. However, as climate change also changes temperature distributions, breeding earlier might increase nestling exposure to either extreme heat or cold. Here, we combine >300,000 breeding records from 24 North American birds with historical temperature data to understand how exposure to extreme temperatures has changed. Average spring temperature increased since 1950 but change in timing of extremes was inconsistent in direction and magnitude; thus, populations could not track both average and extreme temperatures. Relative fitness was reduced following heatwaves and cold snaps in 11 and 16 of 24 species, respectively. Latitudinal variation in sensitivity in three widespread species suggests that vulnerability to extremes at range limits may contribute to range shifts. Our results add to evidence demonstrating that understanding individual sensitivity and its links to population level processes is critical for predicting vulnerability to changing climates.
Microbial methane cycling in a landfill on a decadal time scale
Authors: Grégoire Daniel S. , George Nikhil A. , Hug Laura A. 
Published: November 2023

AbstractLandfills generate outsized environmental footprints due to microbial degradation of organic matter in municipal solid waste, which produces the potent greenhouse gas methane. With global solid waste production predicted to increase substantially in the next few decades, there is a pressing need to better understand the temporal dynamics of biogeochemical processes that control methane cycling in landfills. Here, we use metagenomic approaches to characterize microbial methane cycling in waste that was landfilled over 39 years. Our analyses indicate that newer waste supports more diverse communities with similar composition compared to older waste, which contains lower diversity and more varied communities. Older waste contains primarily autotrophic organisms with versatile redox metabolisms, whereas newer waste is dominated by anaerobic fermenters. Methane-producing microbes are more abundant, diverse, and metabolically versatile in new waste compared to old waste. Our findings indicate that predictive models for methane emission in landfills overlook methane oxidation in the absence of oxygen, as well as certain microbial lineages that can potentially contribute to methane sinks in diverse habitats.
Transcriptional responses of cancer cells to heat shock-inducing stimuli involve amplification of robust HSF1 binding
Authors: Dastidar Sayantani Ghosh , De Kumar Bony , Lauckner Bo , Parrello Damien , Perley Danielle , Vlasenok Maria , Tyagi Antariksh , Koney Nii Koney-Kwaku , Abbas Ata , Nechaev Sergei 
Published: November 2023

AbstractResponses of cells to stimuli are increasingly discovered to involve the binding of sequence-specific transcription factors outside of known target genes. We wanted to determine to what extent the genome-wide binding and function of a transcription factor are shaped by the cell type versus the stimulus. To do so, we induced the Heat Shock Response pathway in two different cancer cell lines with two different stimuli and related the binding of its master regulator HSF1 to nascent RNA and chromatin accessibility. Here, we show that HSF1 binding patterns retain their identity between basal conditions and under different magnitudes of activation, so that common HSF1 binding is globally associated with distinct transcription outcomes. HSF1-induced increase in DNA accessibility was modest in scale, but occurred predominantly at remote genomic sites. Apart from regulating transcription at existing elements including promoters and enhancers, HSF1 binding amplified during responses to stimuli may engage inactive chromatin.