bluuebunny/crossref_metadata_2025_split huggingface dataset:
Evolutionary measures and their correlations with the performance of cross‐version defect prediction for object‐oriented projects
Authors: Yu Qiao , Zhu Yi , Han Hui , Zhao Yu , Jiang Shujuan , Qian Junyan 
Published: October 2023

AbstractCross‐version defect prediction (CVDP) for evolutionary projects has attracted much attention from researchers in recent years. For multiple versions of an object‐oriented project, the degree of evolution (e.g., the degree of class change) between successive versions can reflect the differences between versions, which could affect the performance of CVDP. Therefore, how to measure the degree of evolution between successive versions and explore the correlations with the performance of CVDP are very important for software defect prediction. Based on the successive versions of evolutionary projects, this paper proposes six evolutionary measures from three aspects of class change, metric change, and label change, including the Ratio of New Classes (RNC), the Ratio of Deleted Classes (RDC), the Average Ratio of Metric Change (ARMC), the Ratio of Label Changed Classes (RLCC), the Ratio of Unchanged Classes (RUC), and the Ratio of Interference Classes (RIC). An empirical study was conducted on 40 versions of 11 object‐oriented projects from the PROMISE repository. Precision, Recall, F‐measure, and AUC were used as the performance indicators. Three correlation approaches (Pearson, Spearman, and Kendall) are applied to show the correlations between evolutionary measures and the performance of CVDP. The statistical results show that RNC, RDC, and RUC show no correlation with four performance indicators. ARMC shows weak or medium positive correlations with Recall and F‐measure. RLCC and RIC show very strong or strong negative correlations with Recall and F‐measure. The results indicate that the correlations between the proposed evolutionary measures and the performance of CVDP are different, which can guide the training set selection of CVDP.
Organic Nitrate Additive for High‐Rate and Large‐Capacity Lithium Metal Anode in Carbonate Electrolyte
Authors: Chen Chao , Zhou Qingfeng , Li Xiaodan , Zhao Bote , Chen Yunhua , Xiong Xunhui 
Published: October 2023

AbstractLithium nitrate has been widely used to improve the interfacial stability of Li metal anode in ether electrolyte. However, the low solubility limits its application in carbonate electrolytes for high‐voltage Li metal batteries. Herein, nitrated polycaprolactone (PCL‐ONO2), which is prepared via the acylation of polycaprolactone diol (PCL‐diol) followed by the grafting of nitrate group, has been proposed as an electrolyte additive to introduce high‐concentration NO3− into carbonate electrolytes for the first time. The theoretical calculations and X‐ray photoelectron spectroscopy depth profiling demonstrate that the PCL‐ONO2 additive preferentially reacts with Li metal and in situ constructs a stable dual‐layered solid electrolyte interphase film, presenting an inner nitride‐rich layer and an outer flexible PCL‐based layer on the surface of Li metal anode. As a result, the Li metal anode delivers an impressive long‐term cycling performance over 1400 h at an elevated area capacity of 10.0 mAh cm−2 and an ultrahigh current density of 10.0 mA cm−2 in the Li symmetrical cells. Moreover, the PCL‐ONO2 additive enables the full cells constructed by coupling high‐loading LiFePO4 (20.0 mg cm−2) or LiNi0.5Co0.2Mn0.3 (16.5 mg cm−2) cathode and thin Li metal anode (≈50 µm) to demonstrate greatly improved cycling stability and rate capability.
Piezoelectric Ba0.85Sr0.15TiO3 Nanosonosensitizer with Nitric Oxide Delivery for Boosting Cancer Therapy
Authors: Zhao Yunchao , Wang Shaobo , Yao Shuncheng , Wan Xingyi , Hu Quanhong , Zheng Minjia , Wang Zhuo , Li Linlin 
Published: October 2023

AbstractThe efficacy of sonodynamic therapy (SDT) mainly relies on the sonosensitizers, which generate reactive oxygen species (ROS) upon ultrasound (US) stimulation. However, the limited availability of high‐efficiency sonosensitizers hampers the therapeutic effectiveness of SDT as a standalone modality. In this work, a robust sonodynamic and gas cancer therapeutic platform is constructed based on strontium (Sr) doped barium titanate (BST) piezoelectric nanoparticles functionalized with L‐arginine (BST@LA). The doping of Sr into A site of the ABO3 piezoelectric nanocrystals not only introduces oxygen vacancies into the nanoparticles and enhance the intrinsic piezoelectricity, but also narrows the semiconductor band gap and enhances charge carrier migration, all of which facilitate the sonodynamic production of superoxide anion (•O2−) and hydroxyl radical (•OH). In addition, the generated ROS promotes the decomposition of the surface‐tethered LA, enabling the controlled release of nitric oxide (NO) gas at the tumor site, thereby achieving a combination therapeutic effect. In vivo experiments exhibit remarkable tumor suppression rate (89.5%) in 4T1 tumor mice model, demonstrating the effectiveness of this strategy. The ion doping and oxygen vacancy engineering to improve sonosensitizers, along with the synergistic combination of sonodynamic and gas therapy, provides promising avenues for improving cancer therapy.
Amber extract as a bio‐additive to poly(lactic acid) films: Multimethod analysis of crystallinity and stability
Authors: dos Santos C. A. B. , Ujčić A. , Sobótka M. , Jurczak P. , Lach S. , Rodziewicz‐Motowidło S. , Szustakiewicz K. 
Published: October 2023

AbstractPoly(lactic acid) (PLA) films with 1 wt% of amber extract (AbE) as a bio‐additive were obtained through solvent mixing using 1,4‐dioxane, which was later evaporated. The extract, derived from the residual amber generated during jewelry manufacturing in the Gdansk region (Poland), was evaluated for its morphology and thermal response. The resulting films were transparent, and the addition of AbE imparted a yellow hue. The crystallinity characteristics of the PLA/AbE films were analyzed through FTIR, DSC, POM, and XRD results. The cold crystallization ability of PLA in the presence of AbE was assessed by comparing the films with their annealed counterparts. The annealed films demonstrated a slight increase in the crystalline phase without any change in transparency. The presence of amber extract particles impeded the formation of stable polymorph crystals within the PLA structure, leading to an expanded size distribution of spherulites and a reduced crystallization rate. Furthermore, the addition of AbE showed promise in enhancing the UV–vis blocking of PLA, as AbE particles decreased the transmission rate across the entire UV–vis spectrum.Highlights
PLA thin films with 1% AbE were produced by the casting method.
Amber extract from isopropanol fraction has a porous structure.
PLA and amber extract exhibit homogeneous mixing in 1,4‐dioxane solution.
The AbE particles improved the UV–vis blocking of PLA.
A dog with protothecosis in the Netherlands
Authors: Bontekoning Ilona , Maes Sofie M. J. , Mandigers Paul J. J. 
Published: October 2023

AbstractPrototheca spp. are parasitic algae that can infect humans, cattle, cats and dogs. Although it is rarely seen, if protothecosis occurs in dogs, it is often fatal due to dissemination of the algae and a poor response to treatment. A 3‐year‐old, Scottish Collie dog, female, neutered, was presented with large bowel diarrhoea, weight loss and lethargy of 2 months. The dog had also experienced a short transient episode of acute horizontal nystagmus, left‐sided head tilt and cervical pain 2 weeks before presentation. Histology of the colon demonstrated an erosive neutrophilic colitis with periodic acid–Schiff stain‐positive structures compatible with Prototheca spp. confirmed using polymerase chain reaction. Treatment with nystatin (100,000 IU orally every 8 hours) was unsuccessful, and euthanasia was performed soon after diagnosis. This case report documents the first reported case of canine protothecosis in the Netherlands, and demonstrates that nystatin treatment is not successful in every canine protothecosis case.
Endoscopy and rectal enema for fecal collection in wild sea turtles (Chelonia mydas, Eretmochelys imbricata) in a field setting
Authors: Kaleel Kristina L. , Secoura Patricia L. , Muñoz‐Pérez Juan Pablo , Alarcón‐Ruales Daniela , Vallejo Felipe , Miranda Cristina , Lewbart Gregory A. , Townsend Kathy , Vaden Shelly L. 
Published: October 2023

AbstractForty‐seven free‐ranging sea turtles (46‐ Chelonia mydas, 1‐ Eretmochelys imbricata) were examined via novel use of an endoscopy combined with a rectal enema to obtain large fecal sample volumes. The cloaca was insufflated using an endoscope, after which the bladder and rectum separated, allowing access to the colon. Environmental conditions and location influenced the performance of the procedure initially, but after several attempts the procedure was successfully initiated. In all cases, fecal samples were obtained, and the animals were released to their respective locations. Fecal sample collection using this approach enhances the ability to obtain diagnostic information and perform other scientific analyses of sea turtles.
‘Open Sesame’: Skilled Immigrants’ Experiences with Bridging Programmes in the Validation Process in Norway
Authors: Nortvedt Line , Gillespie Astrid , Dahl Kari , Drange Ida 
Published: October 2023

AbstractInternational agreements on the mutual exchange of skill and labour transcend national borders. Occupational regulations, however, maintain them. Because of this, completion courses and re-education are often the only option for those who seek to reconnect with their pre-migration occupation. These courses usually come last in a chain of requirements which include, e.g., residence permits, language skills, and validation of former education. Our theoretical lens, an ecological framework of resilience inspired by Ungar, allows us to explore success factors within the individual, structural, and political experiences of migrants.We conducted 22 qualitative interviews with candidates enrolled in bridging programmes for nurses, teachers, and engineers in Norway and performed a narrative analysis of the interviews. Our findings show that the participants’ choice of a specific profession was motivated by determination, work opportunities, dreams of a better life, support from family, and the meaningfulness of contributing to society. They spoke of great professional responsibility in their country of origin; as professionals, they were respected in society, which, however, did not correspond with salary levels. In Norway, the participants lost their professional affiliation and encountered difficulties in professional recognition. They were motivated by acknowledgement, authorization, and qualification in the bridging programmes.
Reservoir Computing Based on Iterative Function Systems
Authors: Shimomura Suguru 
Published: October 2023

AbstractVarious approaches have been proposed to construct reservoir computing systems. However, the network structure and information processing capacity of these systems are often tied to their individual implementations, which typically become difficult to modify after physical setup. This limitation can hinder performance when the system is required to handle a wide spectrum of prediction tasks. To address this limitation, it is crucial to develop tunable systems that can adapt to a wide range of problem domains. This chapter presents a tunable optical computing method based on the iterative function system (IFS). The tuning capability of IFS provides adjustment of the network structure and optimizes the performance of the optical system. Numerical and experimental results show the tuning capability of the IFS reservoir computing. The relationship between tuning parameters and reservoir properties is discussed. We further investigate the impact of optical feedback on the reservoir properties and present the prediction results.
Quantum-Dot-Based Photonic Reservoir Computing
Authors: Tate Naoya 
Published: October 2023

AbstractReservoir computing is a novel computational framework based on the characteristic behavior of recurrent neural networks. In particular, a recurrent neural network for reservoir computing is defined as a reservoir, which is implemented as a fixed and nonlinear system. Recently, to overcome the limitation of data throughput between processors and storage devices in conventional computer systems during processing, known as the Von Neumann bottleneck, physical implementations of reservoirs have been actively investigated in various research fields. The author’s group has been currently studying a quantum dot reservoir, which consists of coupled structures of randomly dispersed quantum dots, as a physical reservoir. The quantum dot reservoir is driven by sequential signal inputs using radiation with laser pulses, and the characteristic dynamics of the excited energy in the network are exhibited with the corresponding spatiotemporal fluorescence outputs. We have presented the fundamental physics of a quantum dot reservoir. Subsequently, experimental methods have been introduced to prepare a practical quantum dot reservoir. Next, we have presented the experimental input/output properties of our quantum dot reservoir. Here, we experimentally focused on the relaxation of fluorescence outputs, which indicates the characteristics of optical energy dynamics in the reservoir, and qualitatively discussed the usability of quantum dot reservoirs based on their properties. Finally, we have presented experimental reservoir computing based on spatiotemporal fluorescence outputs from a quantum dot reservoir. We consider that the achievements of quantum dot reservoirs can be effectively utilized for advanced reservoir computing.
FRET Networks: Modeling and Analysis for Computing
Authors: Nakagawa Masaki 
Published: October 2023

AbstractFRET networks, which refer to energy transfer networks between nanoparticles due to Förster resonance energy transfer (FRET), are promising physical phenomena for realizing high-speed, efficient, and compact information processing. These networks can generate rich spatiotemporal signals that help in information processing and are capable of function approximation, time-series prediction, and pattern recognition. This chapter presents a mathematical model and analysis for FRET networks, including some simulation methods for the model, and demonstrates the power of FRET networks for information processing.
Investigation on Oscillator-Based Ising Machines
Authors: Shirasaka Sho 
Published: October 2023

AbstractMoore’s law is slowing down and, as traditional von Neumann computers face challenges in efficiently handling increasingly important issues in a modern information society, there is a growing desire to find alternative computing and device technologies. Ising machines are non-von Neumann computing systems designed to solve combinatorial optimization problems. To explore their efficient implementation, Ising machines have been developed using a variety of physical principles such as optics, electronics, and quantum mechanics. Among them, oscillator-based Ising machines (OIMs) utilize synchronization dynamics of network-coupled spontaneous nonlinear oscillators. In these OIMs, phases of the oscillators undergo binarization through second-harmonic injection signals, which effectively transform the broad class of network-coupled oscillator systems into Ising machines. This makes their implementation versatile across a wide variety of physical phenomena. In this Chapter, we discuss the fundamentals and working mechanisms of the OIMs. We also numerically investigate the relationship between their performance and their properties, including some unexplored effects regarding driving stochastic process and higher harmonics, which have not been addressed in the existing literature.
Insertion eines zweiten Elektrodenträgers – eine seltene Komplikation bei CI-Reimplantation
Authors: Ketterer M. C. , Brückerhoff K. , Arndt S. , Beck R. , Aschendorff A. 
Published: October 2023

ZusammenfassungDie Notwendigkeit der Explantation eines Cochleaimplantats ist sowohl bei technischem Defekt als auch aus medizinischer Indikation möglich. Dieser Fall zeigt, dass bei Reimplantation der Cochlea das Risiko eines nicht luxierbaren Elektrodenträgers, wie hier beschrieben aus der Scala tympani, besteht. Die Insertion eines zweiten Elektrodenträgers in die freie und reizlose Scala vestibuli ist in diesem Fall gelungen. Nichtsdestotrotz muss die Indikation zur Reimplantation insbesondere bei tolerablen Einschränkungen mit nur wenig oder keinem Verlust im Sprachverstehen kritisch gestellt werden und sollte nicht allein aufgrund eines gewünschten Implantat-Upgrades durchgeführt werden.
Adjudin improves beta cell maturation, hepatic glucose uptake and glucose homeostasis
Authors: Ren Lipeng , Charbord Jérémie , Chu Lianhe , Kemas Aurino M. , Bertuzzi Maria , Mi Jiarui , Xing Chen , Lauschke Volker M. , Andersson Olov 
Published: October 2023

Abstract
Aims/hypothesis
Recovering functional beta cell mass is a promising approach for future diabetes therapies. The aim of the present study is to investigate the effects of adjudin, a small molecule identified in a beta cell screen using zebrafish, on pancreatic beta cells and diabetes conditions in mice and human spheroids.

Methods
In zebrafish, insulin expression was examined by bioluminescence and quantitative real-time PCR (qPCR), glucose levels were examined by direct measurements and distribution using a fluorescent glucose analogue, and calcium activity in beta cells was analysed by in vivo live imaging. Pancreatic islets of wild-type postnatal day 0 (P0) and 3-month-old (adult) mice, as well as adult db/db mice (i.e. BKS(D)-Leprdb/JOrlRj), were cultured in vitro and analysed by qPCR, glucose stimulated insulin secretion and whole mount staining. RNA-seq was performed for islets of P0 and db/db mice. For in vivo assessment, db/db mice were treated with adjudin and subjected to analysis of metabolic variables and islet cells. Glucose consumption was examined in primary human hepatocyte spheroids.

Results
Adjudin treatment increased insulin expression and calcium response to glucose in beta cells and decreased glucose levels after beta cell ablation in zebrafish. Adjudin led to improved beta cell function, decreased beta cell proliferation and glucose responsive insulin secretion by decreasing basal insulin secretion in in vitro cultured newborn mouse islets. RNA-seq of P0 islets indicated that adjudin treatment resulted in increased glucose metabolism and mitochondrial function, as well as downstream signalling pathways involved in insulin secretion. In islets from db/db mice cultured in vitro, adjudin treatment strengthened beta cell identity and insulin secretion. RNA-seq of db/db islets indicated adjudin-upregulated genes associated with insulin secretion, membrane ion channel activity and exocytosis. Moreover, adjudin promoted glucose uptake in the liver of zebrafish in an insulin-independent manner, and similarly promoted glucose consumption in primary human hepatocyte spheroids with insulin resistance. In vivo studies using db/db mice revealed reduced nonfasting blood glucose, improved glucose tolerance and strengthened beta cell identity after adjudin treatment.

Conclusions/interpretation
Adjudin promoted functional maturation of immature islets, improved function of dysfunctional islets, stimulated glucose uptake in liver and improved glucose homeostasis in db/db mice. Thus, the multifunctional drug adjudin, previously studied in various contexts and conditions, also shows promise in the management of diabetic states.

Data availability
Raw and processed RNA-seq data for this study have been deposited in the Gene Expression Omnibus under accession number GSE235398 (https://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE235398).

Graphical Abstract
Assessment of potential impact of magnetic fields from a subsea high-voltage DC power cable on migrating green sturgeon, Acipenser medirostris
Authors: Wyman Megan T. , Kavet Robert , Battleson Ryan D. , Agosta Thomas V. , Chapman Eric D. , Haverkamp Paul J. , Pagel Matthew D. , Klimley A. Peter 
Published: October 2023

AbstractEmpirical evidence suggests that marine animals perceive and orient to local distortions in the earth’s natural magnetic field. Magnetic fields (MFs) generated by electrified underwater cables may produce similar local distortions in the earth’s main field. Concern exists that these distortions may impact migration movements of MF-sensitive animals. The Trans Bay Cable (TBC) is a ± 200-kV, 400-megawatt, 85-km high-voltage direct current transmission line buried through San Francisco Bay (37° 56′ 8.81″ N, 122° 27′ 0.19″ W). Detections of adult green sturgeon implanted with acoustic transmitters were used from six cross-bay receiver arrays from 2006 to 2015 to investigate how inbound and outbound migration movements through lower portions of their route to/from upstream breeding grounds are related to the TBC’s energization status (off/on) and other local environmental variables. Here, we assess how these variables impacted transit success, misdirection from the migration route, transit times, and migration path locations within stretches between the Bay’s mouth and the start of the Sacramento River. Overall, there was varied evidence for any effect on migration behavior associated with cable status (off/on). A higher percentage of inbound fish successfully transited after the cable was energized, but this effect was nonsignificant in models including temperature. Outbound fish took longer to transit after cable energization. Inbound and outbound migration path locations were not significantly influenced by cable energization, but results suggest a potential subtle relationship between energization and both inbound and outbound paths. Overall, additional migration-based studies are needed to investigate the impact of anthropogenic cables on marine species.
Differences in residual volume above different tracheostomy tube cuffs depending on tube structure, tube tilt angle, and liquid viscosity
Authors: Katsuno Takahiro , Ueha Rumi , Fujisaki Aiko , Unno Takeshi , Cotaoco Carmel , Kaneoka Asako , Koyama Misaki , Sato Taku , Goto Takao , Kondo Kenji 
Published: October 2023

Abstract
Introduction
Proper management of aspirated material above the tracheostomy tube cuff is crucial to prevent complications, such as aspiration pneumonia. This study aimed to thoroughly examine the effects of aspirated liquid viscosity, suction port positioning, and tube tilt angle on residual volume above the cuff (RVAC).

Methods
Five types of tracheostomy tubes (approximately 9 mm outer diameter) were placed through a transparent cylinder with an inner diameter of 18 mm. The cuff was inflated to completely seal the interior of the cylinder. Four liquids with different viscosities were poured onto the cuff, and the liquid above the cuff was suctioned from the side port. The cylinder was angled at 90° and 20°, and each test was performed thrice to determine the average RVAC.

Results
After side-port suctioning, some liquid residue was observed on the cuff of all tracheostomy tubes. The RVAC increased with higher liquid viscosity. The tubes with a longer distance from the suction port opening to the cuff top exhibited more RVAC. Moreover, the RVAC was almost the same regardless of the cylinder angle for tubes with a suction port on the lateral side. However, tubes with backside ports showed a decreased RVAC with cylinder tilt.

Conclusions
This study underscores the persistence of residual material on cuffed tracheostomy tubes even with regular subglottic secretion drainage. This emphasizes the need for specialized tracheostomy tube development aimed at reducing post-suction RVAC. Improved designs can potentially minimize complications associated with residue accumulation.