bluuebunny/crossref_metadata_2025_split huggingface dataset:
Hard Truths
Authors: Strom-Gottfried Kim 
Published: November 2023

Abstract
In 2006, the parents and doctors of Ashley X, a six-year-old with profound brain damage, sought permission to use surgical and medical procedures to permanently stunt her growth. Once the consent of medical specialists and the hospital ethics committee was obtained, physicians performed a hysterectomy, surgically removed Ashley’s breast buds, and administered high doses of estrogen to attenuate her development (Gunther & Diekema, 2006).
The Honorable Barbara Mikulski: Fighting for Social Justice in the U.S. Senate
Authors: Collins Kathryn , Lazzari Marceline 
Published: November 2023

Abstract
Barbara Ann Mikulski was raised in an extended family in a close-knit, Polish-Catholic, working-class neighborhood in East Baltimore. Her early experiences in these environs, combined with sixteen years of Catholic education, were instrumental in shaping the philosophy that has guided her life. Recalling those years, she has said, ‘‘The neighborhood was really our extended family. If Bethlehem Steel was on strike, my father extended credit to the guys. In the middle of a snowstorm, if he didn’t see Miss Sophie, who was a diabetic, he called down there to see if she needed anything. I ran down the oranges’’ (Broder, 1980, p. 149). This was a living lesson in the moral obligations we each have to look out for our neighbors, a lesson Mikulski took very seriously.
Katherine A. Kendall :The Founder of International Social Work
Authors: Watkins Julia 
Published: November 2023

Abstract
It is fair to say that international social work would not be what it is, or where it is today, without Katherine Kendall’s tireless efforts to expand its reach. Born in Scotland during the Progressive Era (and the halcyon days of Hull House!) and undoubtedly influenced by limitations society placed on her as a woman, Katherine fit well in a profession whose core principles include self-determination and the according of respect and dignity to all. An example of Katherine’s worldwide influence on social work is found in the fact that two other women in this book—Armaity Desai and Sattareh Farman Farmaian—cite her as a most valuable source of consultation and support in attaining their professional goals in their respective countries.
Sattareh Farman Farmaian: Bringing Social Work Education to Iran
Authors: Lieberman Alice 
Published: November 2023

Abstract
Born into the ruling Qajar dynasty in Iran, Sattareh Farman Farmaian brought social work to her country when she founded the Tehran School of Social Work. At the time, the concept of professional social work was so foreign to this tribal culture that there was no equivalent in the Persian language for ‘‘social worker,’’ so she made one up: madadkar, which means ‘‘one who helps.’’ But that, she says, is not the most important professional contribution she made in her life. I visited her in October 2006, at her home in Los Angeles. It is filled with photos, books, and art that reflect her devotion to family, and her love for this rich culture.
New and Emerging Methods of Direct Practice: The Revolution in Social Work
Authors: Fischer Joel 
Published: November 2023

Abstract
Social work is in the midst of a revolution. As revolutions go, it is a rather quiet revolution, but it is a revolution nevertheless. It is a revolution in the ways social workers are beginning to view knowledge and practice and in the ways social workers are beginning to use knowledge and conduct practice. It is a revolution that portends great improvements in the direct-practice branch of social work and one that bodes well for dramatically increasing the success of the profession in helping others.
A Framework for Evaluating Empirical Research Reports
Authors: Fischer Joel 
Published: November 2023

Abstract
Empirical research reports are defined in this chapter as published articles based on studies designed to contribute to the social work knowledge base through rigorous, replicable means. A methodology for evaluating the significance and validity of the knowledge derived from such reports is suggested in a framework whose value rests on answers to two basic questions: The first question is addressed in the theme of this book: Research and evaluation should be applicable in social work practice situations, and the field of social work should not be dichotomized into practice and research orientations. These concepts are based on the belief that systematic, orderly procedures of empirical social work research and evaluation provide the most productive means to organize, understand, test, and develop social work knowledge. The capacity to perform competently in the social work profession, therefore, is based on the ability to analyze and utilize the results of social work research and evaluation.
An Eclectic Approach for Persons with Substance-related Disorders
Authors: Fischer Joel 
Published: November 2023

Abstract
There is little question that substance abuse is one of the hot topics from the 1980s up until today. Both the lay and the professional literature are rife with references to the problems and dangers associated with substance use and abuse—and rightly so. The direct and indirect costs of substance abuse—in terms of dollars and lives—are enormous. However, the real issues involved sometimes are lost in the virtual national hysteria that has arisen since the days of the Reagan administration. The hysteria regarding drug usage in the United States has been well documented by Abbie Hoffman (1987) in his book Steal This Urine Test. Hysteria also can be seen, perhaps, in the statement of a graduate social work student who announced in class that an alcoholism expert in a lecture had asserted that 80 percent of human service professionals either have problems with alcohol themselves or come from families where at least one member does. Finally, the national preoccupation with substance abuse can be seen in President Bush’s declaration in September of 1989 that “the gravest domestic threat facing our nation today is drugs” (Honolulu Advertiser, September 6, 1989, p. A-4).
Evidence-Based Practice
Authors: Fischer Joel 
Published: November 2023

Abstract
Evidence-based practice (EBP) is one of the most important developments in decades for the helping professions—including medicine, nursing, social work, psychology, public health, counseling, and all the other health and human service professions (Briggs & Rzepnicki, 2004; Brownson et al., 2002; Dawes et al., 1999; Dobson & Craig, 1998a, 1998b; Gilgun, 2005; Roberts & Yeager, 2004; Sackett et al., 2000). That is because evidence-based practice holds out the hope for practitioners that we can be at least as successful in helping our clients as the current available information on helping allows us to be. Both the importance and the multidisciplinary nature of EBP can be seen in the Roberts and Yeager (2004) compendium, Evidence-Based Practice Manual, a collection of chapters describing the meaning, methods, and examples of EBP. Evidence-based practice represents both an ideology and a method. The ideology springs from the ethical principle that clients deserve to be provided with the most effective interventions possible. The method of EBP is the way we go about finding and then implementing those interventions (see, e.g., manuals on EBP methods by Gibbs, 2003; Cournoyer, 2003; and Rubin, 2007; see also http:// www.evidence.brookscole.com/index.html). Evidence-based practice represents the practitioner’s commitment to use all means possible to locate the best (most effective) evidence for any given problem at all points of planning and contacts with clients. This pursuit of the best knowledge includes extensive computer searches, as described in the following (Gibbs & Gambrill, 2002).
Mindfulness and Reflexivity: The No-Self as Reflexive Practitioner
Authors: Bères Laura G 
Published: November 2023

Abstract
As described in chapter 1, there is a range of different ways of consider- ing mindfulness and incorporating it into social work practice. This chapter defines mindfulness as the practice of intentionally focusing attention on what is occurring in the present moment in a nonjudgmental manner, with an interest in being rather than doing (Kabat- Zinn, 1990).
Dissection and reconstruction of the colorectal cancer tumor microenvironment
Authors: Broguiere Nicolas , Lorenzo Martin Luis Francisco , Ragusa Simone , Rivest François , Brandenberg Nathalie , Hoehnel-Ka Sylke , Dutta Devanjali , Gueye Marième , Alpern Daniel , Deplancke Bart , Kandalaft Lana , Coukos George , Homicsko Krisztian , Lutolf Matthias P. 
Published: November 2023

AbstractPatient-derived organoids (PDOs) are the referencein vitrohuman disease models. However, the utility of colorectal cancer (CRC) PDOs is hindered by the lack of a tumor microenvironment (TME). To address this limitation, we built a living biobank of CRC PDOs with autologous stromal and immune TME. We characterized the original tumors and traditional monocultures using single-cell RNA-seq (scRNA-seq) and whole exome sequencing (WES) to obtain insights into cell type selection and phenotypic drift in culture. Subsequently, we developed culture conditions supporting all cell types to recapitulate the CRC-TME around PDOs. From the transcriptomes of >180k cells obtained from 260 such co-cultures, we illuminated the mutual influence of cells within CRC tumors. Based on original tumor data, atlases of predicted interactions and transcriptional networks elucidated why monocultures were altered and suggested that TME reconstruction more accurately reflected original tumor behavior. We found that inflammatory signals were absentin vitroand recovered upon co-culture with tumor-infiltrating lymphocytes (TILs). We also functionally confirmed that stromal, not cancer cells, mediated immune evasion. Additionally, stroma induced an invasive phenotype in cancer cells. From this deep dive into CRC-TME interactions, we built the human CRC-TME atlas (https://crc-tme.com/), an online portal for interactive exploration of gene expression data, prediction of cell-cell interactions at the pathway and receptor/ligand levels, transcriptional networks, and more. We anticipate PDO cultures with reconstructed TMEs will be valuable for discovery efforts, preclinical studies, and personalized medicine, with the atlas as a framework and inspiration for future CRC-TME studies.
Predicting gender from structural and functional connectomes via brain and population graph neural networks
Authors: He Yinan , Chan Yi Hao , Rajapakse Jagath C. 
Published: November 2023

AbstractGender differences in terms of structural and functional organization of the human brain have been extensively studied, but existing works have mostly been limited to single modalities. In this paper, we propose a graph attention network architecture (BrainGAT) that uses informative subjectlevel features extracted from multimodal brain graphs to construct a population graph for gender classification. We show that while the extracted subject-level features can be directly used for classification, using these graph embeddings to construct a population graph further improves model performance. On the gender classification task, BrainGAT outperforms baseline models and existing multimodal modeling approaches, achieving an accuracy of 83.13% on the Human Connectome Project dataset. Salient connections highlighted by BrainGAT include connections between the inferior parietal and dorsolateral prefrontal areas of the cortex for females, while connections within the posterior cingulate cortex are highly salient for males. In sum, BrainGAT enables multimodal data to be modelled via population graphs in a parameter-efficient way.Clinical RelevanceSeveral neurological conditions exhibit significant differences across genders and multimodal studies on these diseases are increasingly prevalent. This work highlights gender differences of multimodal connectomes in neurotypical settings. These insights could help to separate multimodal disease biomarkers from fundamental gender differences.
Molecular subtypes of high-grade serous ovarian cancer across racial groups and gene expression platforms
Authors: Davidson Natalie R. , Barnard Mollie E. , Hippen Ariel A. , Campbell Amy , Johnson Courtney E. , Way Gregory P. , Dalley Brian K. , Berchuck Andrew , Salas Lucas A. , Peres Lauren C. , Marks Jeffrey R. , Schildkraut Joellen M. , Greene Casey S. , Doherty Jennifer A. 
Published: November 2023

AbstractIntroductionHigh-grade serous carcinoma (HGSC) gene expression subtypes are associated with differential survival. We characterized HGSC gene expression in Black individuals and considered whether gene expression differences by race may contribute to poorer HGSC survival among Black versus non-Hispanic White individuals.MethodsWe included newly generated RNA-Seq data from Black and White individuals, and array-based genotyping data from four existing studies of White and Japanese individuals. We assigned subtypes using K-means clustering. Cluster- and dataset-specific gene expression patterns were summarized by moderated t-scores. We compared cluster-specific gene expression patterns across datasets by calculating the correlation between the summarized vectors of moderated t-scores. Following mapping to The Cancer Genome Atlas (TCGA)-derived HGSC subtypes, we used Cox proportional hazards models to estimate subtype-specific survival by dataset.ResultsCluster-specific gene expression was similar across gene expression platforms. Comparing the Black study population to the White and Japanese study populations, the immunoreactive subtype was more common (39% versus 23%-28%) and the differentiated subtype less common (7% versus 22%-31%). Patterns of subtype-specific survival were similar between the Black and White populations with RNA-Seq data; compared to mesenchymal cases, the risk of death was similar for proliferative and differentiated cases and suggestively lower for immunoreactive cases (Black population HR=0.79 [0.55, 1.13], White population HR=0.86 [0.62, 1.19]).ConclusionsA single, platform-agnostic pipeline can be used to assign HGSC gene expression subtypes. While the observed prevalence of HGSC subtypes varied by race, subtype-specific survival was similar.Statement of SignificanceA single pipeline was used to subtype ovarian high-grade serous carcinoma (HGSC) with array-based or RNA-Seq gene expression data. Subtype distributions differed by race, but subtype-specific survival was similar across racial groups.
Dehydrozaluzanin C- derivative protects septic mice by alleviating over-activated inflammatory response and promoting the phagocytosis of macrophages
Authors: Zou Ying-xiang , Xiang Tian-nan , Xu Li-rong , Zhang Huan , Ma Yu-he , Zhang Lu , Zhou Chun-xian , Wu Xiao , Huang Qi-lin , Lei Biao , Mu Jing-wen , Qin Xiang-yang , Jiang Xin , Zheng Yue-juan 
Published: November 2023

AbstractHost-directed therapy (HDT) is a new adjuvant strategy that interfere with host cell factors that are required by a pathogen for replication or persistence. In this study, we assessed the effect of dehydrozaluzanin C-derivative (DHZD), a modified compound from dehydrozaluzanin C (DHZC), as a potential HDT agent for severe infection. LPS-induced septic mouse model and Carbapenem resistantKlebsiella pneumoniae(CRKP) infection mouse model was used for testingin vivo. RAW264.7 cells, mouse primary macrophages, and DCs were used forin vitroexperiments. Dexamethasone (DXM) was used as a positive control agent. DHZD ameliorated tissue damage (lung, kidney, and liver) and excessive inflammatory response induced by LPS or CRKP infection in mice. Also, DHZD improved the hypothermic symptoms of acute peritonitis induced by CRKP, inhibited heat-killed CRKP (HK-CRKP)-induced inflammatory response in macrophages, and upregulated the proportions of phagocytic cell types in lungs.In vitrodata suggested that DHZD decreases LPS-stimulated expression of IL-6, TNF-α and MCP-1 via PI3K/Akt/p70S6K signaling pathway in macrophages. Interestingly, the combined treatment group of DXM and DHZD had a higher survival rate and lower level of IL-6 than those of the DXM-treated group; the combination of DHZD and DXM played a synergistic role in decreasing IL-6 secretion in sera. Moreover, the phagocytic receptor CD36 was increased by DHZD in macrophages, which was accompanied by increased bacterial phagocytosis in a clathrin- and actin-dependent manner. This data suggests that DHZD may be a potential drug candidate for treating bacterial infections.
Reconciling the spectrum of RORγt+antigen-presenting cells
Authors: Park Tyler , Leslie Christina , Rudensky Alexander Y. , Brown Chrysothemis C. 
Published: November 2023

AbstractThree recent contemporaneously published papers1–3showed that antigen-presenting cells (APC) expressing the nuclear receptor RORγt instruct peripheral regulatory T (pTreg) cell differentiation and establish tolerance to the gut microbiota. These studies identified a spectrum of RORγt+APCs, distinct from dendritic cells, that included type 3 innate lymphoid cells (ILC3s) as well as novel APC types. Given the discordant conclusions as to the nature of the pTreg-inducing APC and the divergent nomenclature used in these three studies, there is a clear need to reconcile these analyses and the identity of the cell types described. Our reanalysis of the single cell RNA-seq data from these studies revealed the presence of four distinct subsets of non-ILC3 RORγt+APCs, present in all three datasets reported, and confirmed expression of Itgb8, the critical factor for RORγt+APC mediated pTreg induction, in cells synonymous with the non-Aire expressing Thetis cell subset, TC IV.
A Generalized Supervised Contrastive Learning Framework for Integrative Multi-omics Prediction Models
Authors: Yang Sen , Wang Shidan , Wang Yiqing , Rong Ruichen , Li Bo , Koh Andrew Y. , Xiao Guanghua , Liu Dajiang , Zhan Xiaowei 
Published: November 2023

AbstractRecent technological advances have highlighted the significant impact of the human microbiome and metabolites on physiological conditions. Integrating microbiome and metabolite data has shown promise in predictive capabilities. We developed a new supervised contrastive learning framework, MB-SupCon-cont, that (1) proposes a general contrastive learning framework for continuous outcomes and (2) improves prediction accuracy over models using single omics data. Simulation studies confirmed the improved performance of MB-SupCon-cont, and applied scenarios in type 2 diabetes and high-fat diet studies also showed improved prediction performance. Overall, MB-SupCon-cont is a versatile research tool for multi-omics prediction models.
Hippocampal Dipeptidyl Peptidase 9 Bidirectionally Regulates Memory Via Synaptic Plasticity
Authors: Zhao Ya-Bo , Wang Shi-Zhe , Guo Wen-Ting , Wang Le , Tang Xun , Li Jin-Nan , Xu Lin , Zhou Qi-Xin 
Published: November 2023

AbstractIt has been reported that peripherally expressed subtypes of the dipeptidyl peptidase (DPP) family, such as DPP4, modulate memory. However, interestingly whether DPP9 which one of the central nervous systems (CNS) enriched isoforms, regulates memory has not been elucidated yet. Here, we report that DPP9, which is found almost exclusively in neurons, is highly expressed and has high enzyme activity in many brain regions, especially in the hippocampus. Hippocampal DPP9 expression increases after fear memory formation. Fear memory was weakened by DPP9 knockdown and enhanced by DPP9 protein overexpression in the hippocampus. According to subsequent hippocampal proteomics, multiple pathways were enriched by DPP9 expression changes, including the peptidase pathway, which can be bidirectionally regulated by DPP9, and pathways involved in the regulation of synaptic plasticity. DPP9 interacts with its enzymatic substrate neuropeptide Y (NPY) in neurons directly. Hippocampal long-term potentiation (LTP), a form of synaptic plasticity, further confirmed the key role of DPP9 in decreasing LTP through DPP9 knockdown and enhancing LTP through its overexpression. Moreover, inhibiting DPP9 enzyme activity impairs both plasticity and memory. Besides, Affinity purification mass spectrometry (AP-MS) revealed that DPP9-interacting proteins are involved in the functions of dendritic spines and axons. By combining AP-MS and proteomics, DPP9 was shown to play a role in regulating actin functions. Taken together, our findings reveal that DPP9 affects the CNS not only through enzymatic activity but also through protein‒protein interactions. This study provides new insights into the molecular mechanisms of memory and DPP family functions.
Microbial abundance and diversity in 64-74 Ma subseafloor igneous basement from the Louisville Seamount Chain
Authors: Sylvan Jason B. , Tully Benjamin J. , Morono Yuki , Alt Jeffrey C , Grim Sharon L. , Inagaki Fumio , Koppers Anthony A.P. , Edwards Katrina J. 
Published: November 2023

AbstractThe aquifer in subseafloor igneous basement is a massive, continuous microbial substrate, yet sparingly little is known about life in this habitat. The work to date has focused largely on describing microbial diversity in young basement (<10 Ma) at oceanic spreading regions and ridge flanks, where the basaltic crust is still porous and fluid flow through it is active. While the prevailing belief used to be that fluid flow through older parts of the seafloor was non-existent, recent heat flow models predict that fluid moves through subseafloor basement >65 Ma, and that seamounts can act as mid-plate conduits for fluids into and out of the subsurface aquifer in older crustal settings. Here we test the hypothesis that microbial life exists in subseafloor basement >65Ma using samples collected from the Louisville Seamount Chain via seafloor drilling. Cell biomass was heterogeneous in nature and ranged from below detection to ∼104cells cm-3. Bacterial 16S rRNA genes from core samples and enrichment incubations are dominated by lineages putatively carrying out hydrocarbon oxidation and nitrogen, sulfur and metal redox processes. Samples from two different seamounts were statistically different, indicating some degree of biogeography. Archaea were not detected via quantitative polymerase chain reaction, indicating they are rare in the Louisville subsurface. Taken together, the data indicate that microbial life is indeed present in subseafloor igneous basement >65 Ma, which significantly expands the range of the subseafloor biosphere where microbial life is known to exist.Impact StatementThe aquifer in subseafloor igneous basement is the largest continuous microbial substrate on Earth, but it is difficult to access and therefore understudied. We here collected samples from the Louisville Seamount Chain using seafloor drilling to determine if microbial life exists in the >65 Ma subseafloor basement made at these seamounts. A low biomass environment dominated by Bacteria potentially capable of using the Fe and S inherent in subseafloor basalt was detected, including Bacteria that were revived in enrichment experiments. This discovery expands the range of seafloor where confirmed microbial life exists and indicates the interior of seamounts is habitable.