bluuebunny/crossref_metadata_2025_split huggingface dataset:
Evaluation of Haemato-biochemical Effects of Tiletamine-zolazepam Alone and in Combination with Xylazine or Xylazine-ketamine in Atropinized Dogs
Authors: . Sulekha , Kandpal Manjul , Singh Shivani 
Published: November 2023

Background: Tiletamine-zolazepam is a good injectable anaesthetic widely used in veterinary patients and thus the present study was planned to evaluate the effect of tiletamine-zolazepam alone and in combination with xylazine and xylazine-ketamine in dogs. Methods: Eighteen dogs irrespective of age, breed, sex and body weight (requiring various surgical corrections) were randomly divided into three groups namely A, B and C. Atropine sulphate was administered in all the groups followed by tiletamine-zolazepam in group A, xylazine and tiletamine-zolazepam in group B and xylazine, ketamine and tiletamine-zolazepam in group C. The efficacy of the anaesthesia was evaluated at different time intervals upto recovery by observing clinical, physiological and haemato-biochemical parameters. Result: Induction dose of tiletamine-zolazepam observed in group A, B and C was 6.5, 5.5 and 4.0 mg/kg body weight, respectively. Induction time values were decreased and duration of anaesthesia was increased from group A to group C. All physiological parameters differs significantly (p less than 0.05) between the groups. Mean values of Hb, TEC, PCV, TLC, lymphocytes, monocytes, eosinophils, basophils and total proteins showed transient decrease whereas neutrophils, ALT, AST, total bilirubin, plasma glucose, BUN and serum creatinine showed transient increase in all the groups at 30 and 60 minutes. Haemato-biochemical parameters approached to baseline values upto 24 hours. Thus, it can be concluded that the various combinations of tiletamine-zolazepam with pre-medicants like xylazine and xylazine-ketamine was found to be safe with regard to their effects on haemato-biochemical parameters.
Quantitative assessment of the traditional uses of Invasive Alien Plants in Mizoram, an Indo-Burma Biodiversity hotspot region in India
Authors: Sengupta Rabishankar , Dash Sudhansu Sekhar 
Published: November 2023

The present communication enumerates 104 of invasive alien plant species (IAPs) under 83 genera and evaluates the various socio-economic use patterns among the indigenous community of Mizoram. Based on growth form, herbs are most dominant and 39% of total traditional use is based on leaves. Decoction is the most favoured method of preparation of doses while the latex is the least preferred. Solanum torvum with 1.19 has the maximum use value while Gomphrena globosa with 0.07 has the minimum use value.Â The study also revealed 35 types of common disorders under 11 ailment categories which were cured by local plants. Amongs various ailments, digestive system disorder is the most common and sexual ailments are the least.Â Analysis of use value of traditional used plants is the first of its kind in the state of Mizoram which describes the importance of IAPs in the traditional health care practice and socio-economic status of local inhabitants. The study may be a valuable baseline data for further bioprospecting research on IAPs in the area.
Effect of Pressure and Temperature Variation on Wax Precipitation in the Wellbore of Ultradeep Gas Condensate Reservoirs
Authors: Zhang Chao , Gu Zihan , Cao Lihu , Wu Hongjun , Liu Jiquan , Li Pengfei , Zhang Dexin , Li Zhaomin 
Published: November 2023

Summary
To investigate the wax precipitation mechanism of condensate in a wellbore during the ultradeep gas condensate reservoir development, condensate samples were prepared in this work. Changes in the temperature and pressure of fluid flow in the wellbore are simulated by a high-temperature and high-pressure pressure/volume/temperature (PVT) system. This simulation explores their influences on the wax precipitation of the condensate produced from the target reservoir. The results show that the temperature decrease weakens the wax molecular movement activity and promotes the precipitation of wax, resulting in the expansion of the pressure range in which wax precipitation occurs in the system. Meanwhile, decreasing the pressure promotes wax aggregation by increasing van der Waals forces between wax molecules, thereby increasing the wax precipitation rate. At different temperatures, the wax precipitate amount first increases and then decreases with decreasing pressure, which is determined by the wax solubility and remaining content in the system. Since the solubility of a low carbon number component is more sensitive to temperature and pressure changes than that of a high carbon number component, in the early stages of experimental temperature and pressure decreases, the precipitation of coarse crystalline wax with carbon numbers ranging from C16 to C30 is more active than that of microcrystalline wax with carbon numbers exceeding C30. The remaining amount of the former component in the system decreases rapidly, and its precipitation capacity weakens, thus increasing the amount of the latter component in the precipitated wax during the later stage of experiments; this trend corresponds to the shift of the curve peak of the wax carbon number distribution to an abscissa interval with the relatively high carbon numbers. This work can provide reference data for the prediction of the well depth at which the wax precipitation occurs and the wax composition, aiming to promote the implementation of wellbore wax blockage prevention programs.
Dysregulation of SMURF1 by miR-1292-5p involves in lung adenocarcinoma EMT via BMPR2/p-Smad5 signal pathway
Authors: Liu Dewei , Li Lixia , Xu Zhiyi , Huang Jiawei , Zhao Xuanna , Chen Tingting , Li Dongming , Wu Bin , Liang Zhu , Huang Dan , Wu Dong 
Published: November 2023

Abstract

MicroRNAs have been shown to play a vital role in lung adenocarcinoma (LUAD) progression. In this study, we examined the underlying mechanism and biological functions of miR-1292-5p in LUAD. In LUAD tissues and cell lines, the expression of miR-1292-5p was detected using quantitative real-time polymerase chain reaction. The impact of miR-1292-5p in LUAD cells was assessed both in vitro and in vivo, while the formation of filopodia was analyzed through immunofluorescence staining. Analysis of clinical features revealed the correlation of miR-1292-5p expression and LUAD prognosis. The regulatory relationship of miR-1292-5p and SMURF1 was investigated by dual-luciferase assay and rescue experiment. The signal pathway of epithelial-to-mesenchymal transition was analyzed by western blot. The expression of miR-1292-5p, an upregulated miRNA, was detected in LUAD tissues and cell lines. Its expression showed correlation with the prognosis of LUAD. In vitro and in vivo experiments demonstrated that the overexpression of miR-1292-5p led to the promotion of migration and invasion in LUAD cells. Additionally, it induced the formation of filopodia. Mechanistically, miR-1292-5p targeted SMURF1 to regulate epithelial-to-mesenchymal transition via the BMPR2/p-Smad5 signal pathway in LUAD cells. Our study reveals that dysregulation of SMURF1 targeted by miR-1292-5p influences migration and invasion, and induces epithelial-to-mesenchymal transition by activating the BMPR2/p-Smad5 signal pathway in LUAD.
Comparison of earthquake location parameters determined using grid search and manta ray foraging optimization
Authors: Tunçel Aykut 
Published: November 2023

Abstract

Earthquake location estimation using grid search (GS) method are compared with manta ray foraging optimization (MRFO) solutions for synthetic and real earthquake data from Van city, Türkiye. Both locating methods worked very well and achieved similar results. While the coordinates (latitude and longitude) of the earthquake were obtained successfully with both methods, from the inversion of the arrival times calculated from the noisy and noise-free synthetic earthquake data, the result was obtained with some deviation in the depth parameter for the noisy data. The location parameters obtained from the inversion of the real earthquake data using GS and MRFO methods were obtained in accordance with the solutions made by other seismology centres. It was not observed that the depth parameter for the Van earthquake was in full match with the solutions of the seismology centres, but the solutions of the seismology centres given for comparison are also not consistent among themselves. The depth parameter obtained for the Van earthquake according the methods performed in this study is self-consistent and was obtained around 24 km. As a result, GS method has some disadvantageous compared with the MRFO method, for reasons such as reaching the solution tardy and needs applying gradual steps to accelerate it. The MRFO method is easy, fast, and advantageous when performed for the kinematic location of earthquake hypocentre.
Interaction between ambient CO and temperature or relative humidity on the risk of stroke hospitalization: A medical records-based study in Ningxia, China, 2014-2019
Authors: Liu Zhuo , Wang Xingtian , Lu Wenwen , Geng Yuhui , Ma Xiaojuan , Meng Hua , Su Xinya , Pan Dongfeng , Liang Peifeng 
Published: November 2023

Abstract

Background
Although the independent effects of ambient CO and temperature or humidity on stroke have been supported by much evidence, it is still unclear where there is an interaction between these factors and who is sensitive populations for these.
Methods
We extracted information of hemorrhagic or ischemic stroke from the homepage of the discharge medical records. The ambient CO and temperature, humidity were collected from National Monitoring Center. A generalized additive model, the double contamination model was used to analyze the independent effects of CO and temperature or humidity on stroke hospitalization.The bivariate response surface model and stratified analysis were used to evaluate the interaction between these factors.
Findings
High temperature and CO levels had synergistic effects on hemorrhagic stroke(RERI = 0.05, 95% CI: 0.033 ~ 0.086) and ischemic stroke(RERI = 0.035, 95% CI: 0.006 ~ 0.08). Low relative humidity and CO were synergistic in hemorrhagic stroke (RERI = 0.192,95% CI: 0.184 ~ 0.205), but in ischemic stroke, low relative humidity and CO were synergistic only in the elderly group (RERI = 0.056,95%CI: 0.025 ~ 0.085).
Interpretation
Exposure to CO increases the risk of hospitalization related to hemorrhagic and ischemic strokes. CO and temperature or humidity interact with risk of stroke hospitalization with sex and age differences.
The Effects of Breed, Season and Site on Pre-weaning Performance of Dalland and Duroc Pig Breeds and Their Reciprocal Crosses
Authors: Mbeure Sherpherd , Moyo Margaret T , Mlilo Dedani , Moyo Busani 
Published: November 2023

Abstract

Pig performance depends on their genetic merit and the environment in which they are raised. A research study aimed at evaluating the pre-weaning performance of offspring obtained from Dalland and Duroc pure breeds and their reciprocal crosses was carried out. Records of 267 sows in first and second parity comprising 2751 piglets were collected from two Pig Industry Board Farms in Arcturus and Bulawayo. Reproductive and pre-weaning data including number born alive, weaning percentage, average weaning weight, average daily gain and pre-weaning mortality were collected. The analysis of variance (ANOVA) fitted with a mixed model of the General Linear Model procedure of Minitab version.14 was used to analyze the data to establish breed, season and site effects as well checking for existence of first order interactions. Where differences in means were observed, the means were separated using the Turkey’s test at 5% level of significance. Results from this study revealed that breed significantly affected (p < 0.05) average birth weight with pure Dalland and Duroc breeds having heavier piglets of 1.57kg compared to 1.56kg for Dalland boar x Duroc sow and 1.49kg for Duroc boar x Dalland sow respectively. Other pre-weaning performance parameters such as number born alive, weaned percentage, average weaning weight, pre-weaning average daily gain and pre-weaning mortality (%) were similar for pure breeds and reciprocal crosses. Performances of pigs across sites and across seasons were similar. There were no first order interactions suggesting that the performance of the Duroc, Dalland pig breeds and their reciprocal crosses was similar across sites and seasons.
Defining usual care comparators when designing pragmatic trials of complex health interventions: a methodology review
Authors: Turner Katrina M , Huntley Alyson , Yardley Tom , Dawson Sarah , Dawson Shoba 
Published: November 2023

Abstract
Background Pragmatic trials evaluating complex health interventions often compare them to usual care. This comparator should resemble care as provided in everyday practice. However, usual care can differ for the same condition, between patients and practitioners, across clinical sites and over time. Heterogeneity within a usual care arm can raise methodological and ethical issues. To address these it may be necessary to standardise what usual care entails, although doing so may compromise a trial’s external validity. Currently there is no guidance detailing how researchers should decide the content of their usual care comparators. We conducted a methodology review to summarise current thinking about what should inform this decision.
Methods MEDLINE, Embase, CINAHL and PsycINFO were searched from inception to January 2022. Articles and book chapters that discussed how to identify or develop usual care comparators were included. Experts in the field were also contacted. Reference lists and forward citation searches of included articles were screened. Data were analysed using a narrative synthesis approach.
Results 1930 records were identified, 1611 titles and abstracts screened, 112 full texts screened, and 16 articles included in the review. Results indicated that the content of a usual care comparator should be informed by the aims of the trial, existing care practices, clinical guidelines, and characteristics of the target population. Its content should also be driven by the trial’s requirements to protect participants, inform practice, and be methodologically robust, efficient, feasible and acceptable to stakeholders. When deciding the content of usual care, researchers will need to gather information about these drivers, balance tensions that might occur when responding to different trial objectives, and decide how usual care will be described and monitored in the trial.
Discussion When deciding the content of a usual care arm, researchers need to understand the context in which a trial will be implemented and what the trial needs to achieve to address its aim and remain ethical. This is a complex decision-making process and trade-offs might need to be made. It also requires research and engagement with stakeholders, and therefore time and funding during the trial’s design phase.
Methodology review registration PROSPERO (CRD42022307324)
State of Health Estimation for Lithium-ion Batteries Based on Mechanism Fundamental Learning under Variable Charging Strategies
Authors: Zhang Chenghui , Li Shipeng , Shang Yunlong , Duan Bin , Liu Kailong , Bi Zhuming , Zhao Guangcai , Li Changlong , Wang Nan 
Published: November 2023

Abstract

Monitoring the State of Health (SOH) of lithium-ion battery is critical to ensure its safe use and prolong the lifespan. Conventional SOH estimation methods require specific charging strategies which brings barrier to practical applications. In this paper, Mechanism Fundamental Learning (MFL) model is proposed to estimate SOH of lithium-ion batteries using charging processes under variable charging strategies and sample segments. The mechanism is that battery voltage and current are signiﬁcantly impacted by the unmeasurable polarization state, which is associated with the usage and charging process. The MFL model learns the underlying mechanism of battery and tracks the internal state by training current and voltage prediction tasks with Long-Short Term Memory models, and shares the extracted information with SOH estimation task by Multi-Task Learning. Finally the SOH is decoupled from the internal state carried by both hidden state and cell state of LSTM. It has assessed the SOH of batteries with a mean absolute error of 0.76% and root mean squared error of 1.04%.
Abandoned Copper Pyrite Mines: Migration of Chemical Elements from the Acid Mine Water Discharge Zone to the Hydrographic Network
Authors: Rybnikova Liudmila , Rybnikov Petr , Navolokina Vera 
Published: November 2023

Abstract
The paper presents a study of river water pollution by acid mine drainage (AMD) in the Middle Urals, Russia. We analyzed the macro- and microcomponent contents of waters and bottom sediments in the area of the abandoned Levikha copper pyrite deposit (Middle Urals, Russia) and variations in these contents throughout the following chain: mine water discharge (acidic environment) - neutralization (alkaline environment) - clarification (acidic environment) - small river (weakly acidic environment) – discharge into the hydrographic network (circumneutral environment). The degree to which the waters at this nature-manmade object are in equilibrium with respect to minerals was assessed, which enabled us to identify secondary mineral formation processes, forms of metal migration in the water bodies, and their impact on the environment.
At sampling points, Ca, Mg, Na, K, Fe(2+), and Mn were found to migrate in all media mainly in free form. In acidic and weakly alkaline media, Cu and Zn tend to migrate both in free form and in the form of sulfate complexes, while in strongly alkaline media - only in the form of hydroxyl complexes. Al migrates in a sulfate and, less often, hydroxide form. Acidic water is supersaturated with respect to the minerals of the oxide and oxide hydroxide groups. Strongly alkaline and weakly alkaline waters are supersaturated in the group of oxides, oxide hydroxides, hydroxides, and sulfates. The waters of all environments are close to equilibrium or are undersaturated with respect to gypsum; and undersaturated with respect to carbonates. The most intense processes of metal precipitation and sorption by bottom sediments occur in a circumneutral medium: the concentration ratio (CR) exceeds n*105 (L/kg) for Al, Fe, Cu, and Pb.
Improved Gender Detection and Age Estimation Using Multimodal Speech Datasets for speech Age Classification
Authors: Younis Hussain A. , Raihana Nur Intan , Samsudin Tien-Ping , Samsudin Nur Hana , Eisa Taiseer Abdalla Taiseerl , Badr Ameer A. , Nasser Maged , Salisu Sani 
Published: November 2023

Abstract
Age estimation and gender detection are essential tasks in speech analysis and understanding, with applications in various domains. Traditional approaches primarily rely on acoustic features extracted from speech signals, which may be limited by environmental noise and recording conditions. To address these challenges, we propose an improved approach that leverages multimodal speech data, combining audio, visual, and textual features for age estimation and gender detection. Our methodology includes a comprehensive analysis of multimodal features, a novel fusion strategy for integrating the features, and an evaluation of a large-scale multimodal speech dataset. Experimental results demonstrate the effectiveness and superiority of our approach compared to state-of-the-art methods in terms of accuracy, robustness, and generalization capabilities. This work contributes to the advancement of speech analysis techniques and enhances the performance of speech-based applications. This study applies four methods, Decision Trees (DT), Random Forests (RF),Neural Networks (CNN), and CNN with cross-validation.. The accuracy of DT, Random Forest, CCN and CNN with cross validation algorithms are 0.9317%, 0.8341%,0.8% and 0.8537%, respectively for male dataset, 0.8563%, 0.657%1, 0.7433% and 0.7682%, respectively for female dataset then 0.8563%, 0.6839%, 0.7241%, 0.7452%, respectively for combined dataset.
Long COVID with Persistent High Fever as the Main Manifestation: A Case Report
Authors: Fang Chuangsen , Zheng Liangliang , Li Ao , Chen Xi , Chen Yanqi 
Published: November 2023

Abstract
Background COVID-19, caused by SARS-CoV-2, has had a profound global impact, affecting millions of people. Long COVID, also known as Post-Acute Sequelae of SARS-CoV-2 infection (PASC), is characterized by persistent symptoms following acute COVID-19, affecting more than 65 million individuals worldwide. In this case report, we highlight a rare occurrence of Long COVID with high fever, underlining its clinical significance.
Case presentation A 34-year-old female with a 24-day history of recurrent fever, initially reaching 37.5°C, accompanied by headache, fatigue, and joint pain, was admitted with a diagnosis of "fever of unknown origin." Extensive testing, including negative nucleic acid tests for the novel coronavirus, negative blood cultures, and normal imaging, prompted the use of blood Next-Generation Sequencing (NGS) to detect COVID-19. Despite repeated negative nucleic acid tests, elevated COVID-19 antibody levels indicated the presence of long COVID. Methylprednisolone was administered, resulting in the resolution of symptoms. The patient remained asymptomatic during the follow-up.
Overlapping Schwarz Method for a Singularly Perturbed Convection-Diffusion Problems with Two Distinct Parameters
Authors: J Jenifa , J Christy Roja 
Published: November 2023

Abstract
In this paper, a system of singularly perturbed convection- diffusion problems with two distinct small parameters is considered. The problem is solved by using hybrid difference scheme on a Shishkin mesh. This proposed scheme is composed of central difference scheme in the layer region and midpoint scheme on outer region. It is shown that the method produces numerical approximations which converge in the maximum norm to the exact solution. Also we have proved that, when appropriate subdomains are used, the numerical approximations generated from the method are shown to be almost second-order uniformly convergent. Furthermore, it is shown that, the two iterations are sufficient to achieve the expected accuracy. Numerical results are presented in the end which support the theoretical results strongly.
A hierarchical model combining process and Raman spectroscopic data for real-time monitoring of cell culture process
Authors: Yin Pei , Tong Jing , Zhang Liwei , Tang Weihua , Jiang Pei , Wan Xun , Guo Meijin 
Published: November 2023

Abstract

Process analytical technology (PAT) is expected to ensure process and product quality consistency through the timely measurement of raw and in-process materials and key process parameters in pharmaceutical production. With the application of multi-wavelength on-line spectroscopy such as NIR, UV andRaman, and the accumulation of on-line process data, multivariate data analysis (MVDA) has surpassed the traditional univariate or bivariate approaches asa more appropriate tool for bioprocess monitoring and characterization. In thisstudy, a multivariate hierarchical model combining on-line process and Ramanspectroscopic data was developed for real-time cell culture process monitoring.Non-invasive spectroscopy, such as NIR and Raman, can provide additional information to the process variable regarding the biochemical attributes of in-processmedia. The objective was to investigate the possible advantages of the hierarchical model using a combined data set compared to the model using process dataonly. A major advantage of the hierarchical approach was its ability to detectand interpret variations for in-process materials that cannot be detected by theprocess model. In addition, the hierarchical model enhanced the understandingof interactions between process and biochemical variables, as well as the impactof such interactions on process evolution. These advantages not only facilitate early fault detection, but also lead to a well-understood process and, ultimately, improved efficiency for process optimization and control.