bluuebunny/crossref_metadata_2025_split huggingface dataset:
Audit of Safety Profile of Drugs Being Used to Treat Elderly Type II Diabetics: Observations from a Tertiary Care Hospital
Authors: Dadibhanvi Akkamma , Palatty Princy Louis , George Thomas , Pais Michael L. J. , Baliga Manjeshwar Shrinath 
Published: December 2023

ABSTRACT

Background and Objective:
The treatment of elderly people who have developed Type II diabetes is a major challenge. Therefore, this study was conducted to ascertain the drug prescription pattern and the adverse effects of drugs in a tertiary care hospital.

Methodology:
This was a cross-sectional, observational study. This study was carried out on 164 elderly patients with diabetes mellitus attending inpatient and outpatient of the institute. This study assesses the prescribing pattern of antidiabetic drugs and adverse drugs reaction to the drugs administered. Naranjo-Algorithm Probability of American depositary receipt (ADR) scale and WHO prescribing indicators were used for assessment. This study also identifies the drug utilization in diabetic patients associated with other co-morbidities.

Results:
Mean age of the patient was 72.5 in both inpatient and outpatient and male:female ratio among inpatient and outpatient 1.5:1 and 1:1.3, respectively. Metformin (biguanide) was the most commonly prescribed antidiabetic drug and was followed by glimepiride. Insulin was used in 65% of inpatient. Potential drug-drug interactions were noted in 71% of inpatient and 50.8% of outpatient. The incidence of ADR observed in this study was3.6%.

Conclusion:
Metformin and glimepiride were the most common drugs used in both inpatient and outpatient groups. Human regular insulin analog was commonly used in both patients group. The poor reporting in pharmacovigilance although mandated by the Indian Council of Medical Research is falling short; in preempting ADR. Effective pharmacovigilance will improve the quality of life in geriatric patients and would help the treating physicians to steer towards safe and effective healthcare.
To Study Utility and Practicality of High-Frequency Ultrasonography to Demonstrate Nerve Involvement in Leprosy
Authors: Tambe Swagata A. , Jerajani Hemangi R. , Bhatt Kalpana D. 
Published: December 2023

ABSTRACT

Background:
Nerve examination in leprosy is subjective. There is a paucity of literature on objective methods to evaluate nerve involvement in Leprosy.

Aims and Objectives:
(1) To measure cross-sectional area (CSA) of nerves and identify echotexural changes in nerves in patients of leprosy by high-frequency ultrasonography (HFUS). (2) To compare HFUS findings in CSA and echotexture of nerves at baseline and after treatment. (3) To compare clinical grading and HFUS grading of nerves before and after treatment.

Methods:
Both newly diagnosed and treated patients of leprosy were included in the study. Nerve examination was done clinically and clinical grading of nerve thickening was done. Then, thickened nerves were subjected to HUFS to examine CSA (CSA) and echotextural changes. Nerves were also graded by HFUS grading. Parameters such as CSA, echotextural changes, and clinical and HFUS grading were compared before and after completion of treatment.

Observations:
Sixty-four leprosy patients were studied. Most of the patients in our study were in the third and fourth decade with a male preponderance and the mean age of presentation is 35.75 years. A total of 154 peripheral nerves were studied in 64 leprosy patients. Borderline tuberculoid leprosy (BTH) was the most common type of leprosy. The ulnar nerve was the most commonly imaged nerve followed by the greater auricular nerve. There was a statistically significant difference in CSA of nerves before and after treatment. Only 7 of 23 patients, who were found to have features of neuritis on USG, were clinically symptomatic. Three patients were diagnosed to have nerve abscesses.

Conclusion:
HFUS appears to be an objective, simple method to evaluate nerve involvement in leprosy. It is also useful to diagnose silent neuritis and nerve abscess.

Limitations:
All the peripheral nerves were not examined in healthy controls and leprosy patients.
Effect of Acidic Ph on Push-Out Bond Strength of Various Root Repair Materials – An In vitro Study
Authors: Paunikar Mayuri , Bhargava Karan , Newase Pooja , Bawalkar Abhilasha , Shirsath Shreya , Kumar Tanaya , Sarode Gargi 
Published: December 2023

ABSTRACT

Background:
Root repair material ideal characteristics are its ability to adapt to the walls of root canal and avoid leakage of microorganisms and their by-products into the peri-radicular tissue. They should be biocompatible, able to produce osteogenesis and cementogenesis, bacteriostatic, radiopaque, and remain unaffected by blood and moisture. Tissue inflammation and metabolic acidosis following bacterial colonization in pathological condition such as necrotic pulp or periapical abscess lead to change in neutral pH. The pH near periapical tissue lowers to around 5.5. The purpose of this research is to determine the effect of acidic media such as butyric acid on bond strength on mineral trioxide aggregate (MTA), Biodentine (BD), and EndoSequence root repair materials (ERRM) with root dentin wall.

Methodology:
The research was conducted in Vasantdada Patil Dental College. About 60 extracted teeth without any curve canal were selected. They were further divided into three groups of 20 each. Using diamond saw disc, mid root dentin were sectioned horizontally to thickness of 2.0–2.1 mm, further root repair materials were mixed according to instruction given by manufacturer.

Result:
The result concluded that push-out bond strength in both phosphate-buffered saline and acidic environment was higher with ERRM.

Conclusion:
Thickening agent and fillers added in ERRM result in higher push bond strength than MTA and BD.
Evaluation of CDC6 Expression in Triple-Negative Breast Cancer and its Prognostic Significance
Authors: Poornima Arumugam , Banupriya Sampath Kumar , Suganya Kanagaraj , Sudha Balraj , Swathi Kandasamy , Kumar Nachimuthu Senthil , Sumathi Sundaravadivelu 
Published: December 2023

ABSTRACT

Background:
Triple-negative breast cancer (TNBC) leads to high morbidity and poor prognosis due to high proliferation and metastasis. Cell division cycle 6 (CDC6) is one of the genes involved in cell division and is significantly upregulated in TNBC. There is not much information available to understand whether CDC6 can be used as a prognostic marker in TNBC.

Methods:
In this study, BC-GenExMiner, NetworkAnalyst, GeneMania, GEPIA, COSMIC, cBioPortal, STRING, and FunRich were used to investigate the expression of CDC6 gene. Furthermore, survival analysis to correlate the gene expression was carried out using the Kaplan-Meier plotter.

Results:
The results showed that mRNA levels of CDC6 were significantly higher in TNBC compared to healthy and other types of breast cancer, and high expression levels were also associated with increased TNBC proliferation. The survival analysis showed that increased mRNA levels of CDC6 in all TNBC patients were associated with a poor prognosis for relapse-free survival.

Conclusion:
The findings of the current study indicate that CDC6 may be used as a possible prognostic biomarker for TNBC. However, further studies are required to check the effects of CDC6 on the progression and pathogenesis of TNBC.
Changes in Arterial-Alveoli Oxygen Gradient During and after Cardiac Surgery in Patients with Congenital Heart Disease
Authors: Ghasemzade Bahram , Azemati Simin , Jannati Mansour , Asgari Reza 
Published: December 2023

ABSTRACT

Objective:
Disturbance in gas exchange leads to increased ventilation needs, time to stay in the ICU and death. Arterial-alveoli oxygen gradient (A-a) has been studied in adults but has not been considered in children under one year of age who have congenital heart disease and had undergone heart surgery. We decided to examine (A-a) in these patients.

Materials and Methods:
This study is a retrospective study. Patients were divided into two groups based on mortality. Arterial blood gas information was extracted the post-anesthesia, post-bypass, and 4 hours to 16 hours after surgery. The values (A-a) were calculated using a standard formula. Data were analyzed by SPSS software. P < 0.05 was considered statistically significant.

Results:
14 boys and 9 girls were examined. Among these patients, four girls and three boys died. Arterial-alveolar oxygen gradient changes are similar in the living and the dead (P = 0.508). The mean arterial-alveolar oxygen gradients did not show a significant difference between the alive persons and the dead (P = 0.337). Arterial-alveolar oxygen gradient changes during the time, and this change was statistically significant (P = 0.000). Arterial-alveolar oxygen gradient in cardiac surgery in children under one year of age declines up to 16 hours after surgery. The duration of hospitalization (P = 0.290 (or intubation in the ICU (P = 0.792) does not affect the alveolar-arterial oxygen gradient.

Conclusion:
Arterial-alveolar changes in oxygen in heart surgery in children under one year of age were significant during the time and generally decreased 16 hours after the surgery. There was no statistically significant relationship between the length of hospital stay or intubation in the ICU with the arterial alveolar oxygen gradient.
Diencephalic syndrome: A rare etiology of failure to thrive with neuroregression in a child
Authors: Dola Farah Naz , Fatema Kanij , Islam Kazi Ashraful , Nigar Ishrat Zahan , Habiba Umme , Ferdouse Zannatul , Akhter Masuma 
Published: December 2023

Abstract
Diencephalic syndrome, a rare cause of failure to thrive, is associated with intracranial pathology in that region. It is characterized by failure to thrive, emaciation despite normal or slightly reduced calorie intake, and inappropriate euphoria among the young children suffering from tumors in these regions. The actual cause is unknown though different hormones may have a role. Growth hormone may be normal or high. We are presenting the case of a 20-month-old girl who came with failure to thrive in spite of nutritional support, neuroregression, and tremor; ophthalmological evaluation revealed bilateral optic atrophy. MRI revealed an intracranial tumor. This case report aims to show that failure to thrive despite nutritional managements may be the initial presentation of some intracranial pathology.
ULUSLARARASI TİCARETİN SERA GAZI EMİSYONUNDAKİ ETKİSİ
Authors: KOÇUM Müge , GÜNEREN GENÇ Elif 
Published: December 2023

Tarih boyunca ülkeler birbirleri ile ticaret yapmış ve bu ticaretle refah artışı sağlamıştır. Bazı ülkeler için coğrafi nedenler, kaynak eksikliği veya teknolojiden yoksun olma sebepleriyle uluslararası ticaret bir zorunluluk haline gelirken, bazı ülkeler için üretim maliyetleri ve kalite avantajları sebebiyle tercih edilmiştir. Artan üretim ve dış ticaret, beraberinde büyüyen ulaşım altyapısı ile fosil yakıtlarına bağlı enerji tüketiminde artışa bu durum da küresel ısınmanın önemli unsurlarından biri olan sera gazı emisyonunun artışına sebep olmuştur. Bu nedenle kalkınma ve refah artışı sağlayan uluslararası ticaretin, çevre üzerine etkilerinin araştırılması son yıllarda önemli hale gelmiştir.
Amaç: Gelir grupları farklı ülkeler için sera gazı emisyonundaki değişimin nedenlerini özellikle uluslararası ticaret çerçevesinde incelemektir.
Metodoloji: Toplamda 186 ülke, Dünya Bankasından alınan sera gazı emisyon verileri doğrultusunda 1998-2020 yılları için incelenmiştir. Çalışmada ilk önce varsayımdan sapmalar gelişmişlik seviyelerine göre sınıflandırılarak oluşturulmuş dört ülke grubu için ayrı ayrı incelenmiş, logaritmik veri ile analizler yapılmıştır.
Bulgular: Özellikle refah seviyesinde artışa bağlı olarak mal/hizmet ihracatının ve ithalatının sera gazı emisyonunda etkili bir değişken olduğu belirlenmiştir.
Özgünlük: Çalışmanın 186 ülkeyi kapsaması ve bu ülkelerin gelişmişlik seviyelerine göre gruplandırılarak sera gazı emisyonları ile uluslararası ticaret arasındaki bağlantının ortaya konmasıyla ülkelerin düşük karbon ekonomisine geçişte dış ticaret politikaları anlamında fayda sağlayacağı ve ileride yapılacak sektörel çalışmalara zemin oluşturarak katkı sağlayacağı düşünülmektedir.
Kewenangan Pemerintah Daerah Dalam Pengelolaan Wilayah Pesisir dan Pulau-Pulau Kecil
Authors: Sony Edy 
Published: December 2023

Introduction: The regional authority to manage the resources of coastal areas of the sea and small islands as far as 12 miles for the province based on Law No. 9 of 2015 concerning the Second Amendment to Law No. 23 of 2014 concerning Regional Government causes horizontal conflicts of sea plots in the society. Not only conflicts between government institutions (sectoral conflicts) but also related to regional authorities in managing coastal marine resources and small islands.
Purposes of the Research: To analyze various provisions of laws and regulations governing the authority of local governments in the management of coastal areas and small islands, as well as the role of local governments in the management of coastal areas and small islands.
Methods of the Research: The type of research used is normative legal research that studies how legal norms are. The data collection method uses the library research. This study used secondary data obtained from various literature and regulations.
Results of the Research: The results showed that since the enactment of Law Number 23 of 2014 concerning Regional Government, the authority to manage marine waters by the Regency / City Government has decreased. The zoning area as far as 0-4 miles which was originally managed by the Regency / City Government is now managed by the Provincial Government so as to make the zoning of the Provincial authority 0-12 miles. While the authority to manage sea areas more than 12 miles is carried out by the Central Government. In addition, the authority of Regional Governments in the management of coastal areas is also regulated in Law No. 1 of 2014 concerning amendments to Law No. 27 of 2007 concerning Management of Coastal Areas and Small Islands, Article 1 and Article 63 of Regional Governments organize government according to the principle of autonomy, which is a division of elective concurrent government affairs, where Regional Governments play an important role in community empowerment.
Implementasi Kurikulum Merdeka Dalam Pembelajaran Ilmu Pendidikan Islam Di Sekolah
Authors: Widodo Antok , El-Yunusi Muhammad Yusron Maulana 
Published: December 2023

Abstract
Learning of the Islamic education often looks monotonous for students. This is due to several factors such as a lack of innovation from teachers, lagging behind in terms of digitalization, and a lack of ability to adapt their teaching styles to current developments. In addition, the current curriculum is independent learning, where students have the freedom to determine their learning interests. This research aims to find out how the independent curriculum is implemented in learning Islamic education in schools. In planning, implementing and evaluating PAI studies in the independent learning curriculum in schools, this research used qualitative descriptive methods. From the results and discussion it can be concluded that the independent curriculum focuses on developing the character and morals of students. The implementation of the independent curriculum is flexible, thereby giving the freedom to Islamic religious education teachers to develop learning. To achieving these goals, learning outcomes (CP), learning objective flow (ATP), standard documents, learning outcome indicators, and the time required must be determined based on students' learning interests so that students are expected to have maximum learning opportunities and valuable experiences.
Pemanfaatan Lahan Tidur Untuk Peningkatan Ekonomi Keluarga di Kelurahan Pulo Brayan Bengkel Baru Medan Timur
Authors: Sembiring Desi Sri Pasca Sari 
Published: December 2023

Lahan tidur atau terlantar adalah lahan yang sudah tidak digunakan selama lebih dari dua tahun. Lahan tidur yang dimaksud adalah suatu pertapakan /lahan kosong milik warga yang sudah tidak digunakan selama lebih dari dua tahun, sehingga keadaannya semak . Sehingga diharapkan dengan pemanfaatan lahan tidur menjadi optimal dan dapat bermanfaat bagi masyarakat sekitar terutama dalam peningkatan ekonomi keluarga. Tujuan Penelitian: Untuk Mengetahui Bagaimana Peran Kelurahan Pulo Brayan Bengkel Baru dan Stakeholder dalam Pemanfaatan Lahan Tidur dalam Peningkatan Ekonomi Keluarga dan Menganalisis Pendapatan Kelompok Tani yang dihasilkan dari Pemanfaatan Lahan Tidur. Penelitian ini menggunakan analisis deskriptif . Metode Pengambilan Data dilakukan dengan wawancara dan data sekunder dari kelurahan. Responden ditentukan secara Purposive sampling yaitu dengan sengaja yaitu, tokoh Masyarakat, Kelompok Tani Berkah Lingkungan II, Lurah Pulo Brayan Bengkel Baru , ASN Kelurahan, dan Masyarakat sekitar . Dalam mengkaji permasalahan yang ada di gunakan analisis fishbone . Kelurahan Pulo Brayan Bengkel Baru berkolaborasi dengan stakeholder dan semua pihak terkait telah berhasil dalam mengedukasi dan mengajak warga terkait pemanfaatan lahan tidur untuk pemanfaatan lahan tidur. Dari Pemanfaatan lahan tidur yang telah dilakukan kelompok tani memiliki motivasi dan telah mampu menambah pendapatan mereka untuk meningkatkan taraf hidup dapat dilihat dari analisis pendapatan usaha tani mereka .Petani merasakan manfaat berkebun dari tanaman cabai, lengkuas, Sawi dan lainnya. Jelompok Tani di Kelurahan Pulo Brayan Bengkel Baru telah memotivasi masyarakat di sekitar agar memanfaatkan lahan yang belum dikelola.
Aspek Ontologi dan Kosmologi Dalam Ajaran Tasawuf Martabat Tujuh Shaykh Abdul Muhyi Pamijahan
Authors: Abdillah Ali 
Published: December 2023

Shaykh Muhyi Pamijahan merupakan murid Shaykh Abd al-Rauf al-Singkili yang berdakwah menyebarkan ajaran Martabat Tujuh dan Tarekat Shattariyah di Pulau Jawa. Ajaran ini tersebar terutama di kalangan ahli tarekat dan para priyayi. Ajaran Martabat Tujuh Shaykh Muhyi bersumber dari kitab al-Tuhfah al-Mursalah karya Shakh Fadl Allah al-Burhanpuri dari India, namun Shaykh Muhyi memiliki penjelasan Martabat Tujuh Tujuh menggunakan bahasa pegon dalam manuskrip Martabat Kang Pipitu dan beberapa naskah koleksi Leiden Library dengan nomor katalog cod. or 7527 dan 7705. Martabat Tujuh merupakan penjelasan dari aspek ontologi yaitu tajalli dhat wujud qadim meliputi ahadiyah, wahdah dan wahidiyah, dan aspek kosmologi yaitu wujud huduts meliputi ‘alam arwah, ‘alam mithal, ‘alam ajsam dan Insan kamil. Penelitian ini menggunakan pendekatan sufistik untuk mengetahui tarekat yang diikuti oleh seorang sufi dan bagaimana karakteristik penafsirannya terhadap Martabat Tujuh. Hasil kajian ini menyimpulkan bahwa Shaykh Muhyi Pamijahan sebagai tokoh sentral dalam penyebaran Martabat Tujuh di Jawa selain mengikuti tarekat Shattariyah dan beberapa terakat lainnya juga mengikuti Tarekat Qadiriyah Naqsabandiyah. Dengan demikian dapat dipahami bahwa Shaykh Muhyi (w. 1730) sebagai pembawa Tarekat Qadiriyah Naqsabandiyah pertama kali di Nusantara sebelum Shaykh Katib Sambas (w. 1875). Ajaran Martabat Tujuh Shaykh Muhyi memiliki karakteristik penafsiran bercorak Ash’ariyah dengan memilah aspek ontologi yaitu martabat alam qadim (ahadiyah. wahdah. wahidiyah) bersifat tanzih dan aspek kosmologi (alam arwah. mithal, ajsam dan insan) sebagai wujud huduts bersifat tashbih. Selain itu, tetap disiplin dalam pengamalan syariat lahir maupun batin.
ANALISIS PENGARUH RETURN ON ASSETS, DEBT TO EQUITY RATIO DAN CORPORATE SOCIAL RESPOSIBILITY TERHADAP RETURN SAHAM PADA PERUSAHAAN MANUFAKTUR SEKTOR BARANG KOMSUMSI YANG TERDAFTAR DI BURSA EFEK INDONESIA PERIODE 2016-2020
Authors: Muyassaroh Muyassaroh 
Published: December 2023

The company's going concern is supported by the availability of capital for the company. One way for a company to obtain a source of funds is by selling shares to the public in the capital market, however, investors do not simply buy and sell shares. Investors making investments must consider several aspects to minimize the risk of investing in stocks. One of them is by analyzing the company's financial statements that will affect stock returns. These ratios are return on assets to find out if the company gets a profit from its assets, Debt to equity to find out how much the company is financed by debt, Disclosure of Corporate Social Responsibility broadly will cause the company to have a good image in the view of stakeholders. The population of this study are manufacturing companies in the consumer goods industry sector listed on the IDX for the 2016-2020 period, the research sample was taken using a purposive sample method, after being determined according to the criteria, 135 companies were taken as samples. data collection techniques using secondary data, the data collected is analyzed with the Classical Assumption Test and hypothesis testing on SPSS. The results of this study indicate that return on assets, debt to equity and corporate social responsibility affect stock returns in manufacturing companies in the consumer goods industry sector listed on the Indonesia Stock Exchange (IDX) for the 2016-2020 period. Based on the simultaneous significance test with the F test, the value obtained is significance of 0.00. Because the value is smaller than 0.05. The advice that can be given is to decide to invest in stock investments, investors should assess the company's performance through annual reports, especially on return on assets, debt to equity and corporate social responsibility because simultaneously it is very influential on stock returns. it is evident from the results of the R-Square of this study of 65.8%.
Hacia una comunicación con perspectiva de derechos humanos
Authors: Rosenberg Laura 
Published: December 2023

A partir de 2019 medios de comunicación públicos y privados de Argentina comenzaron a incorporar la figura de editora de género. Con escasos antecedentes internacionales –la primera designación se produjo en The New York Times en 2017– el país se convirtió en un caso inédito en América Latina por haber incluido el nuevo perfil periodístico en 13 medios regionales y nacionales en el período 2019-2023. El análisis se sitúa en un contexto sociopolítico muy singular, donde confluyó la masividad del movimiento feminista con reacciones de sectores antifeministas y de la ultraderecha.
Desde un abordaje cualitativo se indaga en los factores que confluyeron en la creación del nuevo rol en los medios argentinos de acuerdo a tres niveles de análisis: el macroestructural, el institucional y el de las trayectorias profesionales de las periodistas que se desempeñaron en el cargo.
El artículo interroga también por los nexos entre este proceso de gestación del nuevo perfil periodístico y la búsqueda por legitimar roles y prácticas periodísticas que se hallen comprometidas con causas de derechos humanos.
Matrimônio religioso segundo Código do Direito Canônico e os efeitos civis
Authors: Oliveira Sueli Almeida de , Costa Lano Alves , Sousa AntônioAlves de , Silva Jorge Luiz Soares da 
Published: December 2023

O matrimônio é uma realidade humana secular, sendo ao mesmo tempo uma realidade totalmente religiosa, uma comunhão do direito divino e humano, no Concilio Vaticano II (Cf. GS 48) foi caracterizado, continuando a tradição eclesiástica de vinculum sacrum. É uma realidade humana e instituição de fé, a origem do matrimônio é um direito anterior a qualquer formulação jurídico-positiva, origina-se na própria natureza humana, cabendo aos ordenamentos reconhecerem e proteger. Não existem dois matrimônios para a Igreja católica, o religioso e o civil, mas um único matrimônio que gera efeitos civis se devidamente registrado conforme estabelece a lei do País. Em decorrência disso, muitas dúvidas têm sido geradas a respeito do matrimônio somente religioso e seu posterior registro civil; do matrimônio religioso e o comprovante da habilitação para o casamento civil; do matrimônio religioso sem o matrimônio civil para não perder o benefício da pensão por morte, assuntos estes dentre outros que serão abordados a seguir a partir do ponto de vista jurídico-canônico.