bluuebunny/crossref_metadata_2025_split huggingface dataset:
KARAKTERISTIK PASIEN KATARAK PADA ANAK YANG TELAH DILAKUKAN OPERASI DI RSUP PROF. DR. I.G.N.G. NGOERAH PERIODE 1 JANUARI - 31 DESEMBER 2021
Authors: Millah Nurhidayatul , Surasmiati Ni Made Ayu , - Siska 
Published: January 2024

ABSTRAK

Katarak tengah menjadi persoalan kesehatan di dunia, pada data World Health Organization (WHO) disebutkan bahwa katarak berkontribusi sekitar 51% sebagai penyebab utama kebutaan di dunia. Insiden katarak di Indonesia diperkirakan 0,1% setiap tahun, maka di antara 1.000 orang ditemukan satu orang pengidap katarak yang baru setiap tahunnya. Masyarakat Indonesia cenderung berisiko 15 tahun lebih cepat menderita katararak daripada masyarakat yang tinggal di daerah yang beriklim subtropis. Diperkirakan kebutaan yang dialami oleh anak-anak di seluruh dunia kurang lebih 5-20% disebabkan oleh katarak, dan sekitar 20.000 – 40.000 anak lahir dengan katarak kongenital setiap tahunnya. Tujuan dari penelitian ini untuk mengetahui karakteristik pasien katarak pada anak yang telah dilakukan operasi di RSUP Prof. Dr. I.G.N.G. Ngoerah periode 1 januari – 31 desember 2021. Penelitian ini merupakan penelitian deskriptif retrospektif dengan pendekatan studi potong lintang, data diambil pada catatan rekam medis pasien. Sampel penelitian ini adalah pasien anak yang didiagnosis katarak dan dioperasi di RSUP Prof. Dr. I.G.N.G. Ngoerah pada periode 1 Januari hingga 31 Desember 2021. Hasil studi ini menunjukkan bahwa terdapat 18 pasien katarak pada anak yang telah dilakukan operasi. Rerata usia pasien saat terdiagnosis adalah 3,61 ± 3,15 tahun dan kelompok rentang usia paling banyak adalah 2 – 5 tahun (50,0%), mayoritas berjenis kelamin perempuan (61,1%). Lateralitas terbanyak yaitu bilateral (55,6%) dengan etiologi paling banyak adalah idiopatik (44,4%). Rerata usia pasien saat dioperasi adalah 4,06 ± 3,12 tahun dan kelompok rentang usia paling banyak adalah 2 – 5 tahun (44,4%). Jenis katarak terbanyak adalah katarak kongenital (66,7%). Seluruh pasien katarak pada anak tidak ditemukan memiliki riwayat keluarga yang menderita katarak (100%). Dapat disimpulkan bahwa katarak pada anak yang telah dilakukan operasi lebih banyak didiagnosis pada usia 2 – 5 tahun dan paling sering ditemukan pada anak perempuan. Mayoritas katarak adalah bilateral dengan etiologi idiopatik. Mayoritas pasien katarak pada anak menjalani operasi pada saat berusia 2 – 5 tahun. Jenis katarak terbanyak adalah katarak kongenital. Semua pasien tidak memiliki riwayat keluarga katarak.
Kata kunci: katarak pada anak, karakteristik, usia
RELATIONSHIP BETWEEN ANEMIA AND ABORTION IN PREGNANT WOMEN AT RSIA ANANDA MAKASSAR 2021-2022
Authors: Azzahrah Nurfauziah , Rahim Rosdianah , Fauziah Henny 
Published: January 2024

Abortion is a condition of pregnancy that ends when the gestational age is less than 20 weeks or the fetus has not been able to live outside the womb. The purpose of this study was to determine the relationship between anemia and the incidence of abortion in pregnant women at the Ananda Mother and Child Hospital Makassar in 2021-2022. This type of research is analytic observational research with a case control study approach. The sampling method used purposive sampling was divided into 102 case samples and 102 control samples. The data consists of being obtained from the medical records of RSIA Ananda Makassar for 2021-2022. Anemia as the independent variable and abortion as the dependent variable. Data were analyzed by univariate test and bivariate test by chi-square test. The research results obtained a p-value of 0.004 (p <0.05) and an OR value of 3.312. The conclusion in this study is that anemia is significantly related to the incidence of abortion at RSIA Ananda Makassar in 2021-2022.
Keywords: Anemia, Abortion
EVALUASI DAYA HAMBAT EKSTRAK DAUN PEGAGAN (Centella asiatica) TERHADAP BAKTERI Streptococcus pyogenes
Authors: Indraningrat Anak Agung Gede , Prihantara Komang Gede Yudha 
Published: January 2024

Faringitis atau sering dikenal sebagai radang tenggorokan merupakan penyakit yang memiliki tingkat prevalensi cukup tinggi di Indonesia. Salah satu patogen penyebab faringitis adalah bakteri Streptococcus pyogenes. Selama ini upaya pengobatan faringitis lebih difokuskan pada terapi antibiotika. Untuk mencegah timbulnya resistensi S. pyogenes terhadap antibiotika, maka salah satu upaya mengatasi faringitis adalah dengan mengembangkan obat-obatan baru yang bersumber dari alam. Pegagan merupakan salah satu jenis tanaman obat yang dimanfaatkan oleh masyarakat secara empiris untuk mengatasi penyakit infeksi karena kandungan senyawa aktifnya yang bersifat antibakteri. Tujuan dari penelitian ini adalah untuk menganalisis daya hambat ekstrak daun pegagan (Centella asiatica) terhadap pertumbuhan S. pyogenes. Penelitian yang dilakukan adalah jenis eksperimental laboratorium dengan rancangan post-test only control group design. Pembuatan ekstrak etanol pegagan dilakukan dengan menggunakan metode maserasi. Sebanyak 150 gram serbuk simplisia pegagan dimaserasi dengan etanol 75% selama 24 jam dengan kecepatan 175 rpm dan didapatkan ekstrak sebanyak 22,48 gram. Skrining antibakteri menggunakan media Mueller Hinton Agar dengan metode Kirby-Bauer pada lima konsentrasi berbeda yaitu 0%, 25%, 50%, 75%, 100%. Sebagai kontrol positif digunakan antibiotika amphicillin. Hasil penelitian ini menunjukkan konsentrasi hambat minimal yaitu 50% dengan diameter zona hambat 6,13 ± 1,02 mm. Sedangkan, rata-rata diameter daya hambat ekstrak tertinggi terhadap S. pyogenes diperoleh pada konsentrasi 100% sebesar 11,39 ± 0,25 mm. Analisis Kruskal-Wallis menunjukkan tidak terdapat perbedaan bermakna antara kelompok kontrol dan kelompok perlakuan yang mengindikasikan daun pegagan mampu menghambat S. pyogenes. Hal ini menunjukkan bahwa terdapat aktivitas antibakteri dari daun pegagan (Centella asiatica) terhadap S. pyogenes. Penelitian lanjutan diperlukan untuk mengetahui komponen senyawa aktif dari ekstrak C. asiatica yang berperan sebagai antibakteri.
The Perception of the American Trypanosomiasis "Disease of Chagas" in the Traditional Community of the Brazilian Amazon
Authors: Dos Santos Rosimar Correa , Rodrigues Pablo Leal , De Melo Naiane Barreira , Pinheiro Luiz Marcelo de Lima , Galvão Gilmar Rodrigues 
Published: January 2024

Objective: To evaluate the perception of residents of the Bacuri community in the municipality of Cachoeira do Arari, Pará, about American trypanosomiasis, known as Chagas disease, in order to expand awareness and control strategies for the disease, in addition to providing specific information about its main vector, the popular barber, and reduce the appearance of epidemiological cases in the region.

Method: An “on-site” visit was carried out, applied to questionnaires composed of open and closed multiple-choice questions and in-depth interviews, with a descriptive statistical analysis being carried out with the aid of the Microsoft Excel 2010 program, calculating the relative and absolute frequency in a quantitative way.

Theoretical reference: the research has its main theoretical bases in current scientific articles on the subject.

Result and conclusion: The results showed that 98% of the participants said they knew the disease superficially and also did not receive visits from health agents, 68% said they only knew those in the chronic phase of the disease. As for the vector 72%, the appearance of these insects is common in the community.

Implications of the research: this work is an important tool for raising awareness among traditional peoples of the Brazilian Amazon for the control and prevention of Chagas disease, in addition to expanding the range of information regarding the disease in the region.

Originality/value: The research indicated that popular knowledge about the disease is of fundamental importance for its treatment and an alternative given the lack of awareness campaigns in the region, which portrays a reality within rural communities in the Brazilian Amazon.
Risk of severe immune-related adverse events in cancer patients with pre-existing autoimmunity receiving immune checkpoint inhibitor therapy
Authors: Isaacs Dayna Jill , Kathuria-Prakash Nikhita , Hilder Robin , Lechner Melissa G. , Drakaki Alexandra 
Published: January 2024

Introduction: Immune checkpoint inhibitors (ICI) are widely used cancer therapies that harness the immune system to target malignant cells but subsequently can cause serious off-target immune-related Adverse Effects (irAEs). Patients with pre-existing autoimmune disease have historically been excluded from ICI clinical trials due to scientific concerns over increased risk of irAEs and flares of underlying autoimmune disease.Methods: We designed a retrospective, single-center, case-control study at a large, academic medical center to evaluate the incidence and severity of irAEs in patients with pre-existing autoimmunity compared to controls. Controls were matched 2:1 for age, sex, cancer histology, and ICI class. Patients were identified with ICD 9 and 10 codes followed by manual chart extraction. Cases were defined as patients with pre-existing, systemic autoimmunity. The primary outcome was severe irAE (Grade 3 or higher by Common Terminology Criteria for Adverse Events) within 6 months of ICI therapy. Secondary outcomes included response to ICIs, resolution of the irAE, ICI rechallenge success, and survival. Statistical analyses were performed by Chi-square, Fishers exact, Mann-Whitney, and Log-rank tests.Results: Of 3,130 patients treated with ICIs from 2015-2021, 28 cases with pre-existing autoimmune disease were identified and were matched with 56 controls. Pre-existing autoimmune conditions included antiphospholipid syndrome, inflammatory polyarthritis, juvenile rheumatoid arthritis, multiple sclerosis, psoriatic arthritis, rheumatoid arthritis, and type I diabetes. Multiple cancer histologies, including genitourinary, gynecologic, head & neck, hepatobiliary, lung, melanoma, and pancreatic, were represented. Six of 28 cases (21.4%) experienced severe irAEs compared to 9/56 (16.1%) controls; the odds of developing a severe irAE were not significantly different (OR 0.43, 95% CI 0.083-2.33, p = 0.627, ns). Moreover, there were no significant differences in overall survival or tumor response between the two groups. The majority of irAEs resolved without long-term sequelae (66.7% of cases, 55.6% of controls). The majority of patients who were rechallenged with ICIs were successful in continuing therapy (66.7% of cases, 100% of controls).Conclusion: Our study suggests that patients with pre-existing autoimmune disease can be treated with ICI cancer therapies and experience rates of severe irAEs and overall survival that are similar to those of the general population. These data can aid oncologists in discussing risks and benefits of ICIs when treating patients with pre-existing autoimmunity and solid tumors.
Percepção dos usuários sobre à assistência no centro de atenção psicossocial
Authors: Braz Patricia Rodrigues , Lomar Aline Fregulia , Almeida Otávio Rodrigo de , Almeida Ana Carolina Ribeiro 
Published: January 2024

Objetivo: Identificar na literatura estudos que abordem as percepções dos usuários dos Centros de Atenção Psicossocial (CAPS) sobre a assistência em saúde mental ofertada no serviço. Métodos: Trata-se de um estudo de revisão sistemática da literatura. A partir da formação de uma questão norteadora, foi realizado o levantamento de dados nas bases da Biblioteca Virtual em Saúde (BVS) e da Web of Science e Scientific Electronic Library (SciELO) das produções científicas publicadas a partir de estudos realizados no Brasil desde 2002. Foram elegíveis para análise 14 artigos. Resultados: A maior satisfação dos usuários se refere à assistência e acolhimento da equipe nos serviços. Um fator amplamente levantado nos estudos diz respeito ao número de profissionais insuficiente para efetivar o tratamento de qualidade no serviço. No que concerne a organização, dispensação e orientação ofertadas sobre as medicações pelo serviço há distinções entre a satisfação e insatisfação. Considerações finais: esse estudo contribuiu para reflexões acerca da efetividade desses serviços na percepção dos usuários e, também, sobre a necessidade de investimento em políticas públicas para melhoria da qualidade da assistência.
INSPEKSI KESELAMATAN JALAN DI RUAS JALAN NASIONAL KOTA JAMBI
Authors: Prastiyo Imam Budy 
Published: January 2024

Abstract

Traffic accidents are often caused by traffic infrastructure conditions that do not meet safety standards. In addition, the interaction between humans and road conditions makes a significant contribution to traffic accidents. Poor road surface conditions, inappropriate geometric design, and lack of road signs can also cause traffic accidents. Road safety inspections are needed to create safer roads, and are used to identify problems and prevent more costly road repairs. The research method used in this study includes the preparation stage, conducting research, and reporting research results. The primary data used was obtained through an inventory survey, while the secondary data required includes national road network data, previous research results, and relevant guidelines or regulations. The results of road safety inspections on 15 national roads in Jambi City show deficiencies in roads, road equipment and ancillary structures, both in quantity and quality.

Keywords: traffic accident; traffic infrastructure; road safety inspections; road deficiency

Abstrak

Kecelakaan lalu lintas seringkali disebabkan oleh kondisi prasarana lalu lintas yang tidak memenuhi standar keselamatan. Selain itu, interaksi antara manusia dan kondisi jalan memberikan kontribusi yang signifikan terhadap kecelakaan lalu lintas. Kondisi permukaan jalan yang buruk, desain geometrik yang tidak tepat, dan kurangnya perambuan di jalan juga dapat menjadi penyebab kecelakaan lalu lintas. Inspeksi keselamatan jalan diperlukan untuk menciptakan jalan yang lebih aman dan selamat, serta digunakan untuk mengidentifikasi masalah dan mencegah perbaikan jalan dengan biaya yang lebih besar. Metode penelitian ini meliputi tahap persiapan, pelaksanaan penelitian, pelaporan hasil penelitian. Data primer yang digunakan diperoleh melalui survei inventarisasi, sedangkan data sekunder yang dibutuhkan mencakup data jaringan jalan nasional, hasil-hasil penelitian sebelumnya, dan pedoman atau regulasi yang relevan. Hasil inspeksi keselamatan jalan di 15 ruas jalan nasional di Kota Jambi menunjukkan adanya defisiensi pada jalan, pada perlengkapan jalan, dan pada bangunan pelengkap, baik secara kuantitas maupun secara kualitas.

Kata-kata kunci: kecelakaan lalu lintas; prasarana lalu lintas; inspeksi keselamatan jalan; defisiensi jalan
INCEDENCE OF THERMODURIC ANTIMICROBIAL-RESISTANT Bacillus AND Enterococcus SPECIES IN SOME DAIRY PRODUCTS
Authors: Elsaid Magdy , Elshaer Manal , Bayoumi Mohamed 
Published: January 2024

Abstract: Livestock meat is considered a potential source of human infection, therefore evaluation of the infection rate with Toxoplasma gondii (T. gondii) in these animals’ meat is needed for public health protection. Serum and meat samples were collected from slaughtered animals (n=106) (27 sheep, 42 cattle and 37 camels) from slaughterhouses in Aswan Governorate, located in southern Egypt. T. gondii infection status was detected by Latex agglutination test (LAT), microscopic examination and PCR. Our results revealed that the overall prevalence of anti-T. gondii antibodies among serum samples was 48.1 % using LAT. Male sheep, cattle, and camels had a higher positive percentage (42.9 %, 69.4% and 33.3 %, respectively) than females (40 %, 50 % and 30.8 %, respectively). The infection rate of T. gondii was higher in adult sheep and camels, while it was lower in adult cattle (64.5 %) than in young (72.7 %). There was a high statistically significant difference (P ≤ 0.01) between the animal species using LAT. T. gondii trophozoites were detected microscopically in 47.1 % of meat samples, while T. gondii DNA was detected in 56.9 % by using conventional Polymerase Chain Reaction (cPCR) based B1 gene. There was no significant difference between the results of both microscopy and PCR methods. In conclusion, PCR outperforms LAT in the detection of T. gondii infection and can thus be applied to routine diagnosis of toxoplasmosis in red meat producing animals.Key words: Aswan; camel ; cattle ; Egypt; LAT; PCR; red meat; sheep; Toxoplasma gondii
THE ANTIBACTERIAL AND ANTIBIOFILM ACTIVITIES OF SILVER NANOPARTICLES ON STAPHYLOCOCCI ISOLATES FROM COW MILK
Authors: Abou-Khadra Sally , El-Amin Amina , Al-Otaibi Saad , Fahmy Hanan 
Published: January 2024

Biofilm-producing ability has been identified as a serious virulence factor in staphylococci and increases their antimicrobial resistance. This study aimed to investigate the biofilm forming ability of staphylococci isolated from cow milk samples. Moreover, we assessed the antibiofilm activity of silver nanoparticles (AgNPs) against methicillin resistant (MRSA) and biofilm forming staphylococci. The results revealed that 82.14% (23/28) and 91.66% (11/12) of the coagulase positive staphylococci (CPS) and coagulase negative Staphylococci (CNS) isolates, respectively produced biofilm on Congo red agar (CRA). In the case of the microtiter plates (MTP) method, all CPS and CNS isolates produced biofilm at different levels. These results revealed a substantial agreement between CRA and MTP results according to the kappa coefficient test (kappa value = 0.773). Staphylococcus aureus species specific nuc gene and the determinant of methicillin resistance (mecA) gene were amplified from S. aureus isolates (n=10). The intercellular adhesion gene A (icaA), and intercellular adhesion gene D (icaD) were amplified from all the CPS and CNS isolates, but none of the isolates were positive for the biofilm associated protein (bap) gene. Antibiotic susceptibility testing showed that all isolates were oxacillin resistant. AgNPs (100 μg/mL) inhibited the growth of Staphylococci isolates (inhibition zone diameters ranged from 22 to 28 mm). AgNPs decreased biofilm formation in the biofilm forming Staphylococci isolates with percent ranged from 67.05 to 98.02% using MTP assay. In conclusion, AgNPs have antistaphylococcal activity and inhibit biofilm formation.
ANTIMICROBIAL RESISTANCE, VIRULENCE-ASSOCIATED GENES, AND FLAGELLIN TYPING OF THERMOPHILIC Campylobacter SPECIES ISOLATED FROM DIARRHEIC HUMANS, RAW MILK, AND BROILER NICHES
Authors: El-Naenaeey El-sayed , Abd El-Aziz Norhan , Sewid Alaa , Hashem Asmaa , Hefny Ahmed 
Published: January 2024

Animal-to-human transmission is frequently linked to commensal bacteria in the gastrointestinal tract, as Campylobacter species. We provide a better insight into the existence of cytolethal distending toxin (cdt) and flagellinA (flaA) genes in different antimicrobial resistance patterns (pandrug-resistance (PDR), extensive drug-resistance (XDR) and multidrug-resistance (MDR)] in Campylobacter species recovered from chickens, milk, and human sources in Egypt. Campylobacter species isolation rate was 89.44%, being 79.50% and 20.50% for C. jejuni and C. coli, respectively. Animal samples (chickens and raw milk) showed a higher prevalence of C. coli (21.17%); whereas C. jejuni was highly documented in human samples (83.33%). Testing of antimicrobial susceptibilities revealed that none of the examined campylobacters was pansusceptible, while PDR (1.86%), XDR (65.53%), and MDR (32.61%) campylobacters were reported. Molecular analysis revealed that 50%, and13.16% of the isolated campylobacters were positive for the cdt and flaA genes, respectively. Interestingly, all flaA-positive isolates were cdt-positive C. jejuni. Restriction fragment length polymorphism-polymerase chain reaction (RFLP-PCR) assay revealed a genetic diversity among flaA harboring isolates presented as three different RFLP patterns of varying sizes ranged from 112 to 647 bp, where flaA-RFLP pattern-I is overrepresented in C. jejuni isolates from various origins (human, milk, and chicken sources). Evidence from this study showed the possibility of treatment failure in campylobacteriosis due to the existence of resistant isolates to all antimicrobial drugs (PDR) and the marked genetic variability of flaA-RFLP pattern that is useful in the epidemiological issues.
THE PROTECTIVE ROLE OF THYMOL AGAINST METHOMYL- INDUCED TOXICITY IN MALE RATS: CLINICO-BIOCHEMICAL, HISTOPATHOLOGICAL AND IMMUNO-HISTOCHEMICAL STUDIES
Authors: Aboushouk Asmaa , Mehana El- Sayed , Oda Samah , Hashem Mohamed , El- Karim Dina 
Published: January 2024

This experiment was carried out to evaluate the presumptive protective effect of thymol (T) against methomyl (M) - induced toxicity in male albino rats. Therefore, forty adult healthy male albino rats were randomly divided into 4 equal groups as follow: control group, intoxicated group received methomyl (4 mg/kg b.wt./day), treated group received thymol (100 mg/kg b.wt.), and co-treated group received both methomyl and thymol with the previous doses. The treatment regimens were given orally three times a week, day after day, for eight weeks. Biochemically, the M- intoxicated rats revealed a significant increase in the serum aminotransferases (ALT& AST) and gamma glutamyle transferase (GGT) activities, total, direct and indirect bilirubin, total cholesterol, triglyceride, low density lipoprotein cholesterol (LDL-C), urea, malondialdehyde (MDA) levels and superoxide dismutase (SOD) activity, in addition to a significant decrease in serum albumin and testosterone levels with a significant increase in the percentage of sperm abnormalities in comparison with the control rats. Regarding to the histopathological examination, M- intoxicated group showed degenerative and necrotic lesions in the hepatic, renal and testicular tissues. But, the co- treatment with thymol ameliorated the M- induced biochemical alterations, oxidative stress and apoptosis and improved tissues architecture. It could be concluded that co-treatment with thymol may provide a prolonged remedy against methomyl -induced toxicity.