bluuebunny/crossref_metadata_2025_split huggingface dataset:
Does ethical climate of the organization foster entrepreneurial marketing? The role of work engagement and effective knowledge transfer
Authors: Khasmafkan-Nezam Mohammah Hossein 
Published: December 2023

Purpose
This study aims to explore how an organization’s ethical climate determines the type and effectiveness of entrepreneurial marketing activities. Also, this study seeks to identify the most critical intra-organizational capabilities related to entrepreneurial marketing components and explain their role in the path of ethical climate to entrepreneurial marketing, which means moving from the intra- to the extra-organizational environment.

Design/methodology/approach
Data were collected from managers working in 100 scientific and research companies in Iran through survey questionnaires. Latent variable structural equation modeling was used to test the hypothesized relationships.

Findings
The findings reveal that the linkage between the ethical climate of the organization and entrepreneurial marketing is partially mediated by work engagement. In addition, the mediating role of knowledge transfer was not confirmed. These results imply that the ethical climate of the organization fosters entrepreneurial marketing by enabling employees with absorption, vigor and dedication.

Research limitations/implications
Scientific and research companies in this research are different in size, resources, knowledge management system, organizational structure and products offered to the market; they have different emphasis on innovation and entrepreneurship as well. This issue increases the variety of data and the ability to generalize the results. Still, on the other hand, it reduces the ability to categorize data and increases the amount of outlier data. Future research in a comparative manner between different industries is needed.

Practical implications
This study indicates that an organization’s ethical climate can be a critical predictor of its entrepreneurial marketing as well as effective knowledge transfer and work engagement. In this regard, organizations should pay attention to employee’s perception of the organization’s ethical climate and create an environment that supports productive behaviors, commitment, trust, communication, work dedication, etc., to facilitate knowledge transfer effectively so that the organization can identify market opportunities and turn it into customer-oriented innovation, cocreate value for their customers and increase market share.

Originality/value
In turbulent markets, companies need to introduce quality and reliable products. Still, because the life cycle of products has shortened and the speed of introducing new products has increased, the supply of products will fail if companies are not equipped with new marketing methods. In this regard, the current research will seek to provide a mechanism for organizational capabilities on the road to entrepreneurial marketing by expressing entrepreneurial marketing as an innovative approach and trying to identify factors affecting it.
Not all sweetness and light: Non‐structural carbohydrate storage capacity in tree stems is decoupled from leaf but not from root economics
Authors: Zhang Guangqi , Mao Zhun , Maillard Pascale , Brancheriau Loïc , Gérard Bastien , Engel Julien , Fortunel Claire , Heuret Patrick , Maeght Jean‐Luc , Martínez‐Vilalta Jordi , Stokes Alexia 
Published: December 2023

ABSTRACT

Non‐structural carbohydrates (NSC) are considered as indicators of the balance between tree carbon sources and sinks and reflect functional strategies throughout different biomes. However, little is known about the contribution of NSC to tree economics, and in particular, whether leaf, stem and coarse root traits co‐ordinate together into a whole‐tree economics spectrum.

Twenty‐four functional traits (including NSC content) were measured in leaves, stem and coarse root xylem of up to 90 angiosperm tree species in temperate, Mediterranean and tropical climates. By performing principal component analysis and standardized major axis regression, we explored the relationships between NSC and other functional traits, as well as the effects of climate and phylogeny on these relationships.

Our results revealed a covariation between leaf and coarse root NSC content and leaf economic traits, whereas stem NSC content was largely decoupled from the leaf economics spectrum that was mostly driven by leaf nitrogen content and leaf mass per area. Coarse root xylem traits were closely correlated with leaf traits, while most stem xylem traits were independent from the leaf economics spectrum but covaried with coarse root traits. Trade‐offs among traits in tropical species opposed those from other climates. Evolutionary history affected relationships among certain traits but did not change overall patterns.

We conclude that due to leaf habit, an extended growing season and heightened defences, tropical species form distinct conservative resource acquisition strategies. Across all climates, as the stem must provide an efficient transport route between roots and leaves, while maintaining the display of branch and leaf organs, stem xylem design and NSC storage capacity lead to a stem economics spectrum that is largely independent from the leaf spectrum, but is coupled with that of coarse roots due to anatomical continuity.

Read the free Plain Language Summary for this article on the Journal blog.
The amenity value of constructed wetlands
Authors: Fernandez Mario A. , Sanchez Gonzalo , Thorsnes Paul 
Published: December 2023

AbstractNatural wetlands in urbanised areas provide practical services, including flood control and amenity values such as views, wildlife habitat and recreational opportunities. But cities also construct wetlands to improve flood control and ecosystem services, the value of which might change property prices. This paper reports analyses of property prices that provide estimates of wetlands' localised amenity values in Auckland, New Zealand's largest city. A major challenge is that the selection of sites for wetlands’ construction is not random; amenity value is potentially confounded by property and neighbourhood characteristics that vary across space and over time. We use a combination of repeat‐sales models, difference‐in‐differences and matching models to control for unobserved heterogeneity in property and neighbourhood characteristics. The results indicate that local benefit from constructed wetlands ranges from about 5% to 9% depending on the location of the property in areas adjacent to the wetlands or in a larger catchment of interest. Our results have a causal interpretation if the selection criteria are applied uniformly across Auckland and are valuable in assessing the benefits of constructed wetlands.
Evaluating energy cost performance in China's thermal power industry: A global cost Malmquist approach
Authors: Zhuang Weiwei , Zhang Jiayu , Zhang Taisheng , Chen Xiang 
Published: December 2023

AbstractWith the inclusion of carbon neutrality in the Government Work Report for the first time at the two sessions held in March 2021 and the strengthening of environmental regulation as well as the increase of limits on polluting gas emissions, it has become increasingly important for China to effectively save energy and reduce carbon for sustainable growth under the “dual carbon” target. Since thermal power generation is the most important source of carbon emissions in China, the thermal power industry is the key to achieving the goal of carbon peaking and carbon neutrality. Therefore, it is of great theoretical and practical importance to study the performance of thermal power generation from the micro perspective of power plants. This paper provides a new perspective on the environmental efficiency measurement of thermal power plants by introducing the cost factors of inputs into the model and constructing a global cost Malmquist productivity index, which can effectively solve the problem of the infeasibility of linear programming and different measures of productivity change, to obtain the productivity performance of China's thermal power industry from 2013 to 2017. The empirical results indicate that: (1) The significant decrease in price effect (PE) is the main driving factor of this situation. (2) Except for the central region, the production technology, technical efficiency, and allocative efficiency related to thermal power generation have increased in the eastern and western regions. Therefore, improving CMG productivity in the central region is more challenging than in the other two regions and improving the PE can significantly improve CMG productivity in China's thermal power industry. This study reveals the spatiotemporal characteristics and influencing factors of production efficiency in China's thermal power industry, which can provide targeted policy guidance for managers to improve the sustainable development of power enterprises.
Dual effects of dietary carnosine during in vitro digestion of a Western meal model with added ascorbic acid
Authors: Li Yi Yao , Yaylayan Varoujan , Palin Marie‐France , Ngapo Tania M. , Cliche Simon , Sabik Hassan , Gariépy Claude 
Published: December 2023

AbstractThe beneficial role of carnosine during in vitro digestion of meat was previously demonstrated, and it was hypothesized that such benefits could also be obtained in a meal system. The current study, therefore, assessed carnosine effects on markers of lipid and protein oxidation and of advanced glycation end products (AGEs) during gastric and duodenal in vitro digestion of a burger meal model. The model included intrinsic (low) and enhanced (medium and high) carnosine levels in a mix of pork mince and bread, with or without ascorbic acid (AA) and/or fructose as anti‐ and prooxidants, respectively. In the presence of either AA or fructose, a carnosine prooxidative potential during digestion was observed at the medium carnosine level depending on markers and digestive phases. However, free carnosine found at the high carnosine level exerted a protective effect reducing the formation of 4‐hydroxynonenal in the gastric phase and glyoxal in both the gastric and duodenal phases. Dual effects of carnosine are likely concentration related, whereby at the medium level, free radical production increases through carnosine's ferric‐reducing capacity, but there is insufficient quantity to reduce the resulting oxidation, while at the higher carnosine level some decreases in oxidation are observed. In order to obtain carnosine benefits during meal digestion, these findings demonstrate that consideration must be given to the amount and nature of other anti‐ and prooxidants present and any potential interactions.Practical ApplicationCarnosine, a natural compound in meat, is a multifunctional and beneficial molecule for health. However, both pro‐ and antioxidative effects of carnosine were observed during digestion of a model burger meal when ascorbic acid was included at a supplemental level. Therefore, to obtain benefits of dietary carnosine during digestion of a meal, consideration needs to be given to the amount and nature of all anti‐ and prooxidants present and any potential interactions.
Performance of contrast‐enhanced mammography for detecting multifocal and multicentric breast cancer and evaluating tumour size, and implications for surgical management: Early experience in a tertiary centre
Authors: Thanh Ha Nguyen Margaret , Varma Nisha , Lan Cheong Wah David , Chew Renny , Botha Tanita , Kouloyan‐Ilic Susan , Paiva Joseph 
Published: December 2023

AbstractIntroductionTo compare diagnostic accuracy of contrast‐enhanced mammography (CEM) with standard 2D digital mammography (equivalent to low‐energy image; LEM) for detection of multifocal and multicentric breast cancer and evaluation of tumour size and disease extent for preoperative planning.MethodsBiopsy proven breast cancer patients who underwent CEM preoperatively between January 2021 and January 2023 were included in this study. CEM and LEM images were independently reviewed by at least two blinded readers. Lesion location, number, size (maximal diameter) and extension across the midline and/or nipple invasion were recorded. Tumour number and size estimated on imaging were compared with final operative histology, which served as the gold standard.ResultsForty‐nine patients (48 females and 1 male) and 50 cases (one patient had bilateral breast lesions) were included in the analysis. Median patient age was 60 (IQR 51, 69). CEM had significantly higher lesion detection rate compared with LEM, with sensitivities of 78% for LEM and 92% for CEM for the index tumour and 15% for LEM and 100% for CEM for multicentric and multifocal cancer. We found no statistically significant difference in median tumour size measurements on CEM and final surgical specimen (P value = 0.97); however, a significant difference was identified in the tumour size measured on LEM and surgical specimen (P value < 0.001).ConclusionCEM is superior to standard 2D digital mammography for detection of multifocal and multicentric breast cancer and is a reliable and more accurate method for estimating tumour size.
Chromosome‐level genome assembly of the aster leafhopper (Macrosteles quadrilineatus) reveals the role of environment and microbial symbiosis in shaping pest insect genome evolution
Authors: Vasquez Yumary M. , Li Zheng , Xue Allen Z. , Bennett Gordon M. 
Published: December 2023

AbstractLeafhoppers comprise over 20,000 plant‐sap feeding species, many of which are important agricultural pests. Most species rely on two ancestral bacterial symbionts, Sulcia and Nasuia, for essential nutrition lacking in their phloem and xylem plant sap diets. To understand how pest leafhopper genomes evolve and are shaped by microbial symbioses, we completed a chromosomal‐level assembly of the aster leafhopper's genome (ALF; Macrosteles quadrilineatus). We compared ALF's genome to three other pest leafhoppers, Nephotettix cincticeps, Homalodisca vitripennis, and Empoasca onukii, which have distinct ecologies and symbiotic relationships. Despite diverging ~155 million years ago, leafhoppers have high levels of chromosomal synteny and gene family conservation. Conserved genes include those involved in plant chemical detoxification, resistance to various insecticides, and defence against environmental stress. Positive selection acting upon these genes further points to ongoing adaptive evolution in response to agricultural environments. In relation to leafhoppers' general dependence on symbionts, species that retain the ancestral symbiont, Sulcia, displayed gene enrichment of metabolic processes in their genomes. Leafhoppers with both Sulcia and its ancient partner, Nasuia, showed genomic enrichment in genes related to microbial population regulation and immune responses. Finally, horizontally transferred genes (HTGs) associated with symbiont support of Sulcia and Nasuia are only observed in leafhoppers that maintain symbionts. In contrast, HTGs involved in non‐symbiotic functions are conserved across all species. The high‐quality ALF genome provides deep insights into how host ecology and symbioses shape genome evolution and a wealth of genetic resources for pest control targets.
Potential of fluoropyrimidine to be an immunologically optimal partner of immune checkpoint inhibitors through inducing immunogenic cell death for thoracic malignancies
Authors: Kozai Hiroyuki , Ogino Hirokazu , Mitsuhashi Atsushi , Nguyen Na Thi , Tsukazaki Yuki , Yabuki Yohei , Ozaki Ryohiko , Yoneda Hiroto , Sato Seidai , Hanibuchi Masaki , Shinohara Tsutomu , Nokihara Hiroshi , Nishioka Yasuhiko 
Published: December 2023

AbstractBackgroundImmune checkpoint inhibitors (ICIs) are a revolutionary paradigm in the treatment of thoracic malignancies and chemoimmunotherapy is a current standard care in this field. Chemotherapeutic agents are known to induce not only direct cytotoxic effects on tumor cells but also immune modulating effects, such as stimulating immunogenic cell death (ICD). Currently, either pemetrexed (PEM) or taxane plus platinum are combined with ICIs for patients with non‐small cell lung cancer (NSCLC); however, it is still unknown whether these agents are immunologically optimal partners for ICIs.MethodsTo determine the immunologically optimal chemotherapeutic agent, we first evaluated the ability of several chemotherapeutic agents, including platinum, PEM, taxane, and 5‐fluorouracil (5‐FU) to induce ICD using several thoracic tumor cell lines in vitro. ICD was evaluated by the cell surface expression of calreticulin (CRT) and adenosine‐triphosphate (ATP) secretion. We further performed an antitumor vaccination assay in vivo.Results5‐FU induced cell surface expression of CRT and ATP secretion most efficiently among the several chemotherapeutic agents. This effect was enhanced when it was combined with platinum. In the antitumor vaccination assay in vivo, we found that vaccination with dying‐AB1‐HA (a murine malignant mesothelioma cell line) cells treated with 5‐FU, but neither PEM nor PTX, reduced the tumor growth of living‐AB1‐HA cells inoculated 1 week after vaccination by recruiting CD3+CD8+ T cells into the tumor microenvironment.ConclusionOur findings indicate that fluoropyrimidine can be an immunologically optimal partner of ICIs through the induction of ICD for thoracic malignancies.
An occupancy analysis of the factors affecting the presence of carnivores at the national park‐human community interface in Rwanda
Authors: Uzabaho Eustrate , Kwizera Noel , Moore Jennifer Frances , Nsabimana Donat 
Published: December 2023

AbstractPeople, livestock and carnivores are constantly interacting especially at the interface between community and protected areas. The carnivore guild category in Volcanoes National Park is important, and if well studied, could lead to additional research opportunities for improved wildlife management. We used single season occupancy models with multi‐species data, to understand the factors affecting species occurrence, detection and distribution among native carnivores of Volcanoes National Park while accounting for imperfect detection and the effects of site variables on the observed trends. Our findings showed that six native carnivores use the park edge, where the side‐striped jackal (Canis adustus) and serval (Leptailurus serval) are the most widespread with ψ = 0.904 (SE 0.051) and ψ = 0.415 (SE 0.086), respectively, followed by African golden cat (Caracal aurata) with ψ = 0.198 (SE 0.066), while the servaline genet (Genetta servalina), slender mongoose (Herpestes sanguineus) and spotted hyaena (Crocuta Crocuta) have very low probability of occupancy with ψ = 0.087 (SE 0.045), ψ = 0.044 (SE 0.032) and ψ = 0.022 (SE 0.022) respectively. In addition, there is high occurrence of feral dogs and human presence in the park edge. Overall, the occupancy of native carnivores increases as distance from settlements increase (β = 0.559 [SE 0.195]) except for hyaena and mongoose which showed a decrease in occupancy as distance to settlements increased. In general, native carnivores preferred sites located close to pasture areas, compared to areas used for agriculture and agroforestry. High overlapping activity between native carnivores and other wildlife varied greatly between species. This study provides the baseline information for the understanding of native carnivores using the park edge and insights on their interactions with other wildlife, livestock and human activities at the interface between the park and local communities. The co‐occurrence of livestock, feral dogs and humans, and native wildlife is a challenge for both wildlife conservation inside the protected area and local communities who might be negatively affected in different ways including interspecific competition, disease exposure and increased conflicts. We anticipate that some of the current livestock keeping are hindered by the challenges of having native carnivores dwelling along the park edge and community interface.
Movement and space use in three sympatric lacertid lizards (Acanthodactylus): Inter‐ and intraspecific comparisons
Authors: Eifler Douglas A. , Eifler Maria A. , Orton Makenna , Utsumi Kaera L. , Jarray Mohsen , Zaidi Ali , Chammem Mohsen 
Published: December 2023

AbstractCompetition can be keen within and between closely related species but can be reduced when sympatric individuals differ in resource use. To determine how sympatric, closely related species coexist, we examined movement and activity of foraging individuals, developing detailed profiles for males of three species (Acanthodactylus boskianus, A. dumerilii and A. scutellatus) and for female A. boskianus in arid sub‐desert steppes of southern Tunisia. All three species were active concurrently with different peak activity times. Males varied markedly in their movement, as did A. boskianus sexes. Interspecifically, male A. boskianus moved most frequently, for the most time, covering the greatest distance and searching the largest area, while male A. dumerilii moved the least often, travelled the shortest distances and intensively searched small areas. Acanthodactylus scutellatus males generally were intermediate between the other species but dug more frequently and had movement rates comparable to A. boskianus. Intraspecifically, A. boskianus females moved less frequently, for a smaller percentage of time, covering shorter distances and searching smaller areas than male A. boskianus. Habitat use varied among species and by sex within A. boskianus. Differences in movement and activity likely reflect differences in resource use that promote coexistence between and within species.
Tezepelumab in patients with allergic and eosinophilic asthma
Authors: Caminati Marco , Buhl Roland , Corren Jonathan , Hanania Nicola A. , Kim Harold , Korn Stephanie , Lommatzsch Marek , Martin Neil , Matucci Andrea , Nasser Shuaib M. , Pavord Ian D. , Domingo Christian 
Published: December 2023

AbstractAsthma is a heterogeneous disease commonly driven by allergic and/or eosinophilic inflammation, both of which may be present in severe disease. Most approved biologics for severe asthma are indicated for specific phenotypes and target individual downstream type 2 components of the inflammatory cascade. Tezepelumab, a human monoclonal antibody (immunoglobulin G2λ), binds specifically to thymic stromal lymphopoietin (TSLP), an epithelial cytokine that initiates and sustains allergic and eosinophilic inflammation in asthma. By blocking TSLP, tezepelumab has demonstrated efficacy across known asthma phenotypes and acts upstream of all current clinically used biomarkers. In a pooled analysis of the phase 2b PATHWAY (NCT02054130) and phase 3 NAVIGATOR (NCT03347279) studies, compared with placebo, tezepelumab reduced the annualized asthma exacerbation rate over 52 weeks by 62% (95% confidence interval [CI]: 53, 70) in patients with perennial aeroallergen sensitization (allergic asthma); by 71% (95% CI: 62, 78) in patients with a baseline blood eosinophil count ≥300 cells/μL; and by 71% (95% CI: 59, 79) in patients with allergic asthma and a baseline blood eosinophil count ≥300 cells/μL. This review examines the efficacy and mode of action of tezepelumab in patients with allergic asthma, eosinophilic asthma and coexisting allergic and eosinophilic phenotypes.