bluuebunny/crossref_metadata_2025_split huggingface dataset:
3D Printing of Cobalt‐Incorporated Chloroapatite Bioceramic Composite Scaffolds with Antioxidative Activity for Enhanced Osteochondral Regeneration
Authors: Shu Chaoqin , Qin Chen , Wu Aijun , Wang Yufeng , Zhao Chaoqian , Shi Zhe , Niu Huicong , Chen Jiajie , Huang Jimin , Zhang Xinxin , Huan Zhiguang , Chen Lei , Zhu Min , Zhu Yufang 
Published: February 2024

AbstractOsteochondral defects are often accompanied by excessive reactive oxygen species (ROS) caused by osteoarthritis or acute surgical inflammation. An inflammatory environment containing excess ROS will not only hinder tissue regeneration but also impact the quality of newly formed tissues. Therefore, there is an urgent need to develop scaffolds with both ROS scavenging and osteochondral repair functions to promote and protect osteochondral tissue regeneration. In this work, by using 3D printing technology, a composite scaffold based on cobalt‐incorporated chloroapatite (Co‐ClAP) bioceramics, which possesses ROS‐scavenging activity and can support cell proliferation, adhesion, and differentiation, is developed. Benefiting from the catalytic activity of Co‐ClAP bioceramics, the composite scaffold can protect cells from oxidative damage under ROS‐excessive conditions, support their directional differentiation, and simultaneously mediate an anti‐inflammatory microenvironment. In addition, it is also confirmed by using rabbit osteochondral defect model that the Co‐ClAP/poly(lactic‐co‐glycolic acid) scaffold can effectively promote the integrated regeneration of cartilage and subchondral bone, exhibiting an ideal repair effect in vivo. This study provides a promising strategy for the treatment of defects with excess ROS and inflammatory microenvironments.
Silver Mineralized Protein Hydrogel with Intrinsic Cell Proliferation Promotion and Broad‐Spectrum Antimicrobial Properties for Accelerated Infected Wound Healing
Authors: Wang Weiqiang , Chu Fengjiao , Zhang Weifeng , Xiao Tingting , Teng Jingjing , Wang Yan , He Bo , Ge Binghui , Gao Jiajia , Ge Honghua 
Published: February 2024

AbstractThe presence of multidrug‐resistant bacteria has challenged the clinical treatment of bacterial infection. There is a real need for the development of novel biocompatible materials with broad‐spectrum antimicrobial activities. Antimicrobial hydrogels show great potential in infected wound healing but are still being challenged. Herein, broad‐spectrum antibacterial and mechanically tunable amyloid‐based hydrogels based on self‐assembly and local mineralization of silver nanoparticles are reported. The mineralized hydrogels are biocompatible and have the advantages of sustained release of silver, prolonged antimicrobial effect, and improved adhesion capacity. Moreover, the mineralized hydrogels display a significant antimicrobial effect against both Gram‐positive and Gram‐negative bacteria in cells and mice by inducing membrane damage and reactive oxygen species toxicity in bacteria. In addition, the mineralized hydrogels can rapidly accelerate wound healing by the synergy between their antibacterial activity and intrinsic improvement for cell proliferation and migration. This study provides a modular approach to developing a multifunctional protein hydrogel platform based on biomolecule‐coordinated self‐assembly for a wide range of biomedical applications.
A‐D‐A Molecule–Bridge Interface for Efficient Perovskite Solar Cells and Modules
Authors: Duan Lianjie , Zheng Dexu , Farhadi Bita , Wu Sajian , Wang Hao , Peng Lei , Liu Lu , Du Minyong , Zhang Youdi , Wang Kai , Liu Shengzhong 
Published: February 2024

AbstractAs the photovoltaic field endeavors to transition perovskite solar cells (PSCs) to industrial applications, inverted PSCs, which incorporate fullerene as electron transport layers, have emerged as a compelling choice due to their augmented stability and cost‐effectiveness. However, these attributes suffer from performance issues stemming from suboptimal electrical characteristics at the perovskite/fullerene interface. To surmount these hurdles, an interface bridging strategy (IBS) is proposed to attenuate the interface energy loss and enhance the interfacial stability by designing a series of A‐D‐A type perylene monoimide (PMI) derivatives with multifaceted advantages. In addition to passivating defects, the IBS plays a crucial role in facilitating the binding between perovskite and fullerene, thereby enhancing interface coupling and importantly, improving the formation of fullerene films. The PMI derivatives, functioning as bridges, serve as a protective barrier to enhance the device stability. Consequently, the IBS enables a remarkable efficiency of 24.62% for lab‐scale PSCs and an efficiency of 18.73% for perovskite solar modules craft on 156 × 156 mm2 substrates. The obtained efficiencies represent some of the highest recorded for fullerene‐based devices, showcasing significant progress in designing interfacial molecules at the perovskite/fullerene interface and offering a promising path to enhance the commercial viability of PSCs.
Practical Applications of Self‐Healing Polymers Beyond Mechanical and Electrical Recovery
Authors: Kim Semin , Jeon Hyeonyeol , Koo Jun Mo , Oh Dongyeop X. , Park Jeyoung 
Published: February 2024

AbstractSelf‐healing polymeric materials, which can repair physical damage, offer promising prospects for protective applications across various industries. Although prolonged durability and resource conservation are key advantages, focusing solely on mechanical recovery may limit the market potential of these materials. The unique physical properties of self‐healing polymers, such as interfacial reduction, seamless connection lines, temperature/pressure responses, and phase transitions, enable a multitude of innovative applications. In this perspective, the diverse applications of self‐healing polymers beyond their traditional mechanical strength are emphasized and their potential in various sectors such as food packaging, damage‐reporting, radiation shielding, acoustic conservation, biomedical monitoring, and tissue regeneration is explored. With regards to the commercialization challenges, including scalability, robustness, and performance degradation under extreme conditions, strategies to overcome these limitations and promote successful industrialization are discussed. Furthermore, the potential impacts of self‐healing materials on future research directions, encompassing environmental sustainability, advanced computational techniques, integration with emerging technologies, and tailoring materials for specific applications are examined. This perspective aims to inspire interdisciplinary approaches and foster the adoption of self‐healing materials in various real‐life settings, ultimately contributing to the development of next‐generation materials.
Dissipation of pendimethalin in a water‐seeded rice field and implications for water management
Authors: Becerra‐Alvarez Aaron , Al‐Khatib Kassim 
Published: February 2024

AbstractWater‐seeded rice (Oryza sativaL.) in California is produced near growing urban centers and a variety of neighboring high‐value crops, which make water quality a paramount concern because of potential herbicide residue contamination in downstream surface waters. Pendimethalin is a potential herbicide for use in California water‐seeded rice. A study was conducted to characterize pendimethalin's dissipation in water of a water‐seeded rice field. A capsule suspension (CS), emulsifiable concentrate (EC), and granule (GR) pendimethalin were applied onto flooded rice plots at 1.1, 2.3, and 3.4 kg ai ha−1rates. Water samples were collected periodically and analyzed with an high pressure liquid chromatography tandem mass spectrometry system for residues. Pendimethalin dissipation differed across formulations. The initial sampled concentrations recorded values from 3.0 to 125.6 parts per billion (ppb). First‐order dissipation resulted in half‐lives for the CS from 2.3 to 3.5 days, the EC from 0.6 to 0.7 days, and the GR from 3.5 to 6.9 days. Pendimethalin use in water‐seeded rice is at low risk of contaminating downstream surface waters; however, early sampled residue concentrations could be concerning. The results can assist in generating management tactics like water‐holding periods to avoid potential downstream off‐target effects and ensure herbicidal activity in the applied area after a pendimethalin application in a water‐seeded rice field.
Anti‐aging effects of icariin and the underlying mechanisms: A mini‐review
Authors: Li Ying , Wei Zhi‐Feng , Su Long 
Published: February 2024

AbstractAging is an extremely intricate and progressive phenomenon that is implicated in many physiological and pathological conditions. Icariin (ICA) is the main active ingredient of Epimedium and has exhibited multiple bioactivities, such as anti‐tumor, neuroprotective, antioxidant, anti‐inflammatory, and anti‐aging properties. ICA could extend healthspan in both invertebrate and vertebrate models. In this review, the roles of ICA in protection from declined reproductive function, neurodegeneration, osteoporosis, aging intestinal microecology, and senescence of cardiovascular system will be summarized. Furthermore, the underlying mechanisms of ICA‐mediated anti‐aging effects will be introduced. Finally, we will discuss some key aspects that constrain the usage of ICA in clinical practice and the corresponding strategies to solve these issues.
Quantum chemical calculation driven insights into deep eutectic solvent‐accelerated photoinduced reversible complexation‐mediated polymerization
Authors: Li Shen , Fu Xin , Zhou Yin‐Ning , Liu Zhong‐Xin , Hou Lin‐Xi , Luo Zheng‐Hong 
Published: February 2024

AbstractDeep eutectic solvent (DES) is used as both photocatalyst and solvent for photoinduced reversible complexation‐mediated polymerization (photo‐RCMP), which enables a rapid polymerization to produce polymers with predictable molar mass and low molar mass dispersity (Đ). This work illustrates a comprehensive understanding of DES‐accelerated RCMP's mechanism and kinetic features through quantum chemical calculations and kinetic modeling. According to the results, electrons transferring from hydrogen bond in DES to iodine atom in alkyl iodide (RI) initiator under light irradiation lowers the decomposition free energy of complex RI‐DES. This procedure facilitates the generation of primary radicals, thus contributing to the DES‐accelerated phenomenon. In the meantime, the reaction paths are identified by computation as (i) decomposition of RI‐DES under light irradiation generates active radicals and ·I‐DES complex and (ii) combination of two ·I‐DES releases iodine (I2) and regenerates DES. In addition, kinetic modeling based on the method of moments successfully identifies kinetic features of polymerization in the presence and absence of DES, respectively. Kinetic modeling shows a fast increase in primary radicals concentration and rapid build‐up of the photo‐RCMP activation‐deactivation equilibrium, demonstrating that DES is a beneficial photocatalyst and solvent to enable the rapid generation of primary radicals and accelerate the completion of catalytic cycle. This research provides an in‐depth understanding of DES‐involved photo‐RCMP and lays a theoretical foundation for expanding the application of DES to other polymerization systems.
Intensive Blood Pressure Treatment and Subclinical Brain Infarcts: A Secondary Analysis of SPRINT (Systolic Pressure Intervention Trial)
Authors: Kern Kyle C. , Nasrallah Ilya M. , Bryan R. Nick , Williamson Jeff , Reboussin David M. , Pajewski Nicholas M. , Wright Clinton B. 
Published: February 2024

ObjectiveSubclinical brain infarcts (SBI) increase the risk for stroke and dementia, but whether they should be considered equivalent to symptomatic stroke when determining blood pressure targets remains unclear. We tested whether intensive systolic blood pressure (SBP) treatment reduced the risk of new SBI or stroke and determined the association between SBI and cognitive impairment.MethodsIn this secondary analysis of SPRINT (Systolic Pressure Intervention Trial), participants ≥50 years old, with SBP 130–180mmHg and elevated cardiovascular risk but without known clinical stroke, dementia, or diabetes, were randomized to intensive (<120mmHg) or standard (<140mmHg) SBP treatment. Brain magnetic resonance images collected at baseline and follow‐up were read for SBI. The occurrence of mild cognitive impairment (MCI) or probable dementia (PD) was evaluated.ResultsFor 667 participants at baseline, SBI were identified in 75 (11%). At median 3.9 years follow‐up, 12 of 457 had new SBI on magnetic resonance imaging (5 intensive, 7 standard), whereas 8 had clinical stroke (4 per group). Baseline SBI (subhazard ratio [sHR] = 3.90; 95% CI 1.49 to 10.24; p = 0.006), but not treatment group, was associated with new SBI or stroke. For participants with baseline SBI, intensive treatment reduced their risk for recurrent SBI or stroke (sHR = 0.050; 95% CI 0.0031 to 0.79; p = 0.033). Baseline SBI also increased risk for MCI or PD during follow‐up (sHR = 2.38; 95% CI 1.23 to 4.61; p = 0.010).InterpretationNew cerebral ischemic events were infrequent, but intensive treatment mitigated the increased risk for participants with baseline SBI, indicating primary prevention SBP goals are still appropriate when SBI are present. ANN NEUROL 2024;95:866–875
Anionic Sublattices in Halide Solid Electrolytes: A Case Study with the High‐Pressure Phase of Li3ScCl6
Authors: Ding Fenghua , Doi Atsunori , Ogawa Takafumi , Ubukata Hiroki , Zhu Tong , Kato Daichi , Tassel Cédric , Oikawa Itaru , Inui Naoki , Kuze Satoru , Yamabayashi Tsutomu , Fujii Kotaro , Yashima Masatomo , Ou Xing , Wang Zhijian , Min Xiaobo , Fujita Koji , Takamura Hitoshi , Kuwabara Akihide , Zhang Tianren , Griffith Kent J. , Lin Zhang , Chai Liyuan , Kageyama Hiroshi 
Published: February 2024

AbstractThe Li3MX6 compounds (M=Sc, Y, In; X=Cl, Br) are known as promising ionic conductors due to their compatibility with typical metal oxide cathode materials. In this study, we have successfully synthesized γ‐Li3ScCl6 using high pressure for the first time in this family. Structural analysis revealed that the high‐pressure polymorph crystallizes in the polar and chiral space group P63mc with hexagonal close‐packing (hcp) of anions, unlike the ambient‐pressure α‐Li3ScCl6 and its spinel analog with cubic closed packing (ccp) of anions. Investigation of the known Li3MX6 family further revealed that the cation/anion radius ratio, rM/rX, is the factor that determines which anion sublattice is formed and that in γ‐Li3ScCl6, the difference in compressibility between Sc and Cl exceeds the ccp rM/rX threshold under pressure, enabling the ccp‐to‐hcp conversion. Electrochemical tests of γ‐Li3ScCl6 demonstrate improved electrochemical reduction stability. These findings open up new avenues and design principles for lithium solid electrolytes, enabling routes for materials exploration and tuning electrochemical stability without compositional changes or the use of coatings.
WH‐Überseequartier in Hamburg – Ingenieurbauwerke und Gründung
Authors: Schadow Thomas , Jansson Nicodemus 
Published: February 2024

AbstractDas zweiseitig am Wasser liegende neue Zentrum WH‐Überseequartier des Stadtteils HafenCity in Hamburg befindet sich nach wechselvoller Geschichte kurz vor der Fertigstellung. Investor, Bauherr und Betreiber des neuen Quartiers mit insgesamt 419.000 m2 Bruttogrundfläche ist das Unternehmen Unibail‐Rodamco‐Westfield. Insgesamt wurden im Quartier 14 aufgehende Gebäude nach Entwürfen nahmhafter Architekturbüros realisiert. In diesem Bericht werden die Herausforderungen der Planung und Umsetzung der vielfältigen, im Quartier notwendigen Ingenieurbauwerke von den Baugruben, dem Umgang mit dem mitten im Baufeld liegenden Haltestellenbauwerk der U‐Bahn, dem erforderlichen Teilersatzneubau des Chicagokais bis zu den Gründungen der neuen Hochbauten und Außenanlagen beschrieben. Im zu einem späteren Zeitpunkt folgenden zweiten Teil werden die Tragwerke der sehr unterschiedlich genutzten Hochbauten aus Sicht der Planung und Bauausführung zusammengestellt.
Longevity Spinach (Gynura procumbens) Ameliorated Oxidative Stress and Inflammatory Mediators in Cisplatin‐Induced Organ Dysfunction in Rats: Comprehensive in vivo and in silico Studies
Authors: Chandra Shill Manik , El‐Nashar Heba A. S. , Prova Mollick Patricia , Nath Acharyya Rabindra , Afrin Silvia , Hossain Hemayet , Halder Shimul , Torequl Islam Muhammad , Bhuia Md. Shimul , Reza Hasan Mahmud , El‐Shazly Mohamed , Mubarak Mohammad S. 
Published: February 2024

AbstractThis study focused to assess the efficacy of Gynura procumbens (GP) leaf extract against cisplatin (CP)‐induced hepatorenal complications in Wister albino rats. Additionally, it aims to detect polyphenolic compounds using high‐performance liquid chromatography with diode‐array detection (HPLC‐DAD). The rats were treated intraperitoneally with CP (7.5 mg/kg) to mediate hepatorenal damage. They were then treated with GP extract (75 and 150 mg/kg, P.O.) for 7 consecutive days. Although GP extract significantly ameliorated CP‐mediated hepatorenal biomarkers like alkaline phosphatase (ALP), alanine aminotransferase (ALT), aspartate aminotransferase (AST), creatinine, and blood urea nitrogen (BUN) levels in a dose‐dependent manner, GP extract at 150 mg/kg dose normalized hepatorenal biomarkers ALP (45.11 U/L), ALT (34 U/L), AST (29 U/L), creatinine (10.3 mg/dl) and BUN (11.19 mg/dl) while comparing to control and disease group. Similarly, though it significantly reduced CP‐induced oxidative stress inducers, including nitric oxide (NO) and advanced oxidative protein products (AOPP), higher dose (150 mg/kg) exhibited better activity in reducing NO (281.54 mmol/gm tissue in liver and 52.73 mmol/gm tissue in the kidney) and AOPP (770.95 mmol/mg protein in liver and 651.90 mmol/mg protein in the kidney). Besides, it showed better enhancement in the antioxidant enzymes superoxide dismutase, and glutathione levels at a higher dose (150 mg/kg). Histopathological studies showed that CP caused collagen accumulation in the liver and kidney tissues. GP extract drained the collagen mass and acted against hepatorenal damage. Ellagic acid, gallic acid, quercetin hydrate, kaempferol, and rutin hydrate were revealed in GP extract. In‐silico modelling showed good docking scores of the polyphenolic compounds with molecular targets including CYP4502E1, NF‐κB, caspase‐3, and TNF‐α. GP could be an effective therapeutic option for management of anticancer drugs’ complications like CP‐induced organ damage, although clinical studies are required to establish herbal formulation.
Design and Synthesis of Novel Phthalide Derivatives containing 1,3,4‐Oxadiazole/1,2,4‐Triazole Units as Potential Antifungal Agents
Authors: Li Yong , Luo Zhongfu , Liu Wenjing , Chen Wenzhang , Wang Jianta , Zhu Gaofeng , Guo Bing , Tang Lei , Fan Lingling 
Published: February 2024

AbstractFour series of novel 1,3,4‐oxadiazole/1,2,4‐triazole hybrids of phthalide derivatives were designed and synthesized to search for novel potential antifungal agents. Preliminary antifungal activity assay results showed that compounds 4 a, 4 b, 4 m, 5 b, 5 f, 5 h, and 7 h exhibited moderate to excellent inhibitory activity against some phytopathogenic fungi. Among them, compound 5 b displayed the most outstanding antifungal effects against V. mali and S. sclerotiorum, with the EC50 mean of 3.96 μg/mL and 5.60 μg/mL, respectively, which was superior to those of commercial fungicides hymexazol and chlorothalonil. Furthermore, compound 5 b could completely suppress the spore germination of V. mali at a concentration of 10 μg/mL. Finally, molecular docking revealed that the potential target for the antifungal activity of compound 5 b was succinate dehydrogenase (SDH). This research provides novel candidate compounds for the prevention of phytopathogenic fungi.
Light‐Activatable Photocaged UNC2025 for Triggering TAM Kinase Inhibition in Bladder Cancer
Authors: Breton‐Patient Chloé , Billotte Sébastien , Duchambon Patricia , Fontaine Gaëlle , Bombard Sophie , Piguel Sandrine 
Published: February 2024

AbstractPhotopharmacology is an emerging field that utilizes photo‐responsive molecules to enable control over the activity of a drug using light. The aim is to limit the therapeutic action of a drug at the level of diseased tissues and organs. Considering the well‐known implications of protein kinases in cancer and the therapeutic issues associated with protein kinase inhibitors, the photopharmacology is seen as an innovative and alternative solution with great potential in oncology. In this context, we developed the first photocaged TAM kinase inhibitors based on UNC2025, a first‐in‐class small molecule kinase inhibitor. These prodrugs showed good stability in biologically relevant buffer and rapid photorelease of the photoremovable protecting group upon UV‐light irradiation (<10 min.). These light‐activatable prodrugs led to a 16‐fold decrease to a complete loss of kinase inhibition, depending on the protein and the position at which the coumarin‐type phototrigger was introduced. The most promising candidate was the N,O‐dicaged compound, showing the superiority of having two photolabile protecting groups on UNC2025 for being entirely inactive on TAM kinases. Under UV‐light irradiation, the N,O‐dicaged compound recovered its inhibitory potency in enzymatic assays and displayed excellent antiproliferative activity in RT112 cell lines.
Electrochemical CO2 Reduction by Urea Hangman Mn Terpyridine species
Authors: Li Minghong , Huang Fang , Zhang Ping , Xiong Ying , Zhang Yaping , Li Fei , Chen Lin 
Published: February 2024

AbstractBased on our previous study in chemical subtleties of the proton tunneling distance for metal hydride formation (PTD‐MH) to regulate the selectivity of CO2 reduction reaction (CO2RR), we have developed a family of Mn terpyridine derivatives, in which urea groups functions as multipoint hydrogen‐bonding hangman to accelerate the reaction rate. We found that such changes to the second coordination sphere significantly increased the turnover frequency (TOF) for CO2 reduction to ca. 360
with this family of molecular catalysts while maintaining high selectivity (ca. 100 %±3) for CO even in the presence of a large amount of phenol as proton source. Notably, the compounds studied in this manuscript all exhibit large value for
as that achieved by Fe porphyrins derivates, while saving up to 0.55 V in overpotential with respect to the latter.
Metal‐(Acyclic Diaminocarbene) Complexes Demonstrate Nanomolar Antiproliferative Activity against Triple‐Negative Breast Cancer
Authors: Katkova Svetlana A. , Bunev Alexander S. , Gasanov Rovshan E. , Khochenkov Dmitry A. , Kulsha Andrey V. , Ivashkevich Oleg A. , Serebryanskaya Tatiyana V. , Kinzhalov Mikhail A. 
Published: February 2024

AbstractHydrolytically stable PdII and PtII complexes supported by acyclic diaminocarbene ligands represent a novel class of structural organometallic anticancer agents exhibiting nanomolar antiproliferative activity in a panel of cancer cell lines (IC50 0.07–0.81 μM) and up to 300‐fold selectivity for cancer cells over normal primary fibroblasts. The lead drug candidate was 300 times more potent than cisplatin in vitro and showed higher efficacy in reducing the growth of aggressive MDA‐MB‐231 xenograft tumors in mice.