bluuebunny/crossref_metadata_2025_split huggingface dataset:
Injectable 3D microcultures enable intracerebral transplantation of mature neurons directly reprogrammed from patient fibroblasts
Authors: Kajtez Janko , Nilsson Fredrik , Laurin Kerstin , Bruzelius Andreas , Cepeda-Prado Efrain , Birtele Marcella , Barker Roger A. , Herborg Freja , Ottosson Daniella Rylander , Storm Petter , Fiorenzano Alessandro , Habekost Mette , Parmar Malin 
Published: December 2023

AbstractDirect reprogramming of somatic cells into induced neurons (iNs) has become an attractive strategy for the generation of patient-specific neurons for disease modeling and regenerative neuroscience. To this end, adult human dermal fibroblasts (hDFs) present one of the most relevant cell sources. However, iNs generated from adult hDFs using two-dimensional (2D) cultures poorly survive transplantation into the adult brain in part due to the need for enzymatic or mechanical cellular dissociation before transplantation. Three-dimensional (3D) culturing methodologies have the potential to overcome these issues but have largely been unexplored for the purposes of direct neuronal reprogramming. Here we report a strategy for directin vitroreprogramming of adult hDFs inside suspension 3D microculture arrays into induced DA neurospheroids (iDANoids). We show that iDANoids express neuronal and DA markers and are capable of firing mature action potentials and releasing dopamine. Importantly, they can be gently harvested and transplanted into the brain of a Parkinson’s disease rat model to reproducibly generate functionally integrated neuron-rich grafts. The 3D culturing approach presented here thus eliminates a major bottleneck in direct neuronal reprogramming field and, due to its simplicity and versatility, could readily be adapted as a culturing platform used for a broad range of transplantation studies as well as disease modeling.
Integrated omics analysis unveils a DNA damage response to neurogenic injury
Authors: Hashemi Gheinani Ali , Sack Bryan S. , Bigger-Allen Alex , Thaker Hatim , Atta Hussein , Lambrinos George , Costa Kyle , Doyle Claire , Gharaee-Kermani Mehrnaz , Patalano Susan , Piper Mary , Cotellessa Justin F. , Vitko Dijana , Li Haiying , Kadayil Prabhakaran Manubhai , Cristofaro Vivian , Froehlich John , Lee Richard S. , Yang Wei , Sullivan Maryrose P. , Macoska Jill A. , Adam Rosalyn M. 
Published: December 2023

AbstractSpinal cord injury (SCI) evokes profound bladder dysfunction. Current treatments are limited by a lack of molecular data to inform novel therapeutic avenues. Previously, we showed systemic inosine treatment improved bladder function following SCI in rats. Here, we applied multi-omics analysis to explore molecular alterations in the bladder and their sensitivity to inosine following SCI. Canonical pathways regulated by SCI included those associated with protein synthesis, neuroplasticity, wound healing, and neurotransmitter degradation. Upstream regulator analysis identified MYC as a key regulator, whereas causal network analysis predicted multiple regulators of DNA damage response signaling following injury, including PARP-1. Staining for both DNA damage (γH2AX) and PARP activity (poly-ADP-ribose) markers in the bladder was increased following SCI, and attenuated in inosine-treated tissues. Proteomics analysis suggested that SCI induced changes in protein synthesis-, neuroplasticity-, and oxidative stress-associated pathways, a subset of which were shown in transcriptomics data to be inosine-sensitive. These findings provide novel insights into the molecular landscape of the bladder following SCI, and highlight a potential role for PARP inhibition to treat neurogenic bladder dysfunction.SynopsisEmployed a multi-omics approach, integrating both transcriptomic and proteomic analyses, to investigate the molecular response in a rat model of spinal cord injury (SCI) and the therapeutic effect of inosine.Discovered multiple regulators of the DNA damage response, including PARP-1, using causal network analysis.Observed decreased markers of DNA damage and PARP activity in inosine-treated tissues, indicating the therapeutic potential of inosine in neurogenic dysfunction.Identified significant alterations in molecular pathways associated with protein synthesis, neuroplasticity, wound healing, and neurotransmitter degradation after SCI, and their modulation by inosine, highlighting its neuroprotective effects beyond DNA damage repair.
Several theoretical issues on the socialist utilization of capital
Authors: Qiu Haiping 
Published: December 2023

PurposeIn the new development stage of comprehensively building a socialist modern state, it is imperative to adhere to the guidance of Xi Jinping Thought on Socialism with Chinese Characteristics for a New Era, comprehensively summarize China's practical experiences in economic development, strengthen research on capital issues, construct theories of socialist political economy with Chinese characteristics regarding capital and provide scientific theoretical guidance for further promoting the positive role of various types of capital while preventing and overcoming their negative effects, which is a major theoretical issue and a glorious task for the theoretical and economic circles in China.Design/methodology/approachFrom the perspective of Marx's theory on capital and historical development, modern capital represents the organizational mode of socialized mass production and market economy. It serves as both the economic foundation of bourgeois society and a tool for socialist economic development.FindingsThe market economy represents an inevitable historical stage and form of socialist economic development, necessitating the adoption of capital as an organizational form within socialist economies.Originality/valueThe utilization of capital to advance a socialist economy is a remarkable achievement by the CPC and Chinese people, representing a significant innovation in both theory and practice. The role of capital is inherently dual under any social condition. In the context of a socialist system, capital can play a positive role effectively, and its behavior can be guided and regulated correctly to curb its negative or even destructive impact.
Transfer of farmland operation rights and improvement of productivity of farmers: theory and empirical evidence
Authors: Mao Peihua , Xu Ji , He Xiaodan , Zhou Yahong 
Published: December 2023

PurposeThe results of this study have significant policy implications for charting a new course toward enhancing agricultural productivity among Chinese farmers.Design/methodology/approachBy establishing a rural household decision-making model based on the transfer market of farmland operation rights, this paper systematically analyzes the effects of land transfer-in and land transfer-out on the productivity (per labor income) of rural households. The authors conducted basic regression analysis and robustness tests using propensity score-matching and proxy variable approaches based on the micro survey data from rural households in 30 counties in 21 provinces/municipalities/autonomous regions in 2013.FindingsAfter the completion of land transfer, the total productivity of rural households transferring in lands will increase with an increase in the agricultural productivity; the total productivity of rural households transferring out land will increase due to a rise in non-agricultural productivity and the absolute total productivity of rural households not involved in land transfer will remain unchanged.Originality/valueUnlike previous literature, this paper discusses the impacts of land transfer-in and transfer-out on total productivity, agricultural productivity and non-agricultural productivity among various rural households (i.e. those transferring in land, transferring out land or which are self-sufficient).
How does age and gender of the employees influence human resource practices–employee competencies relationship?
Authors: Kaur Sukhpreet 
Published: December 2023

PurposeApplying resource-based view and the configurational approach theory, this study seeks to understand the moderating role of age and gender between human resource practices and employee competencies relationship.Design/methodology/approach43 food processing firms of India participated in the study. Applying multilevel approach, the responses of 295 human resource managers and 3,557 employees were used for the analysis.FindingsThe human resource practices–employee competencies relationship was stronger in the case of young employees. Furthermore, the relationship was better in case of male employees over female employees. The results urge for greater attention toward age and gender diversity issues while tailoring human resource practices for enhancing employee skills. This article contributes the human resource management literature by exploring the role of age and gender, which has been used as the control variables as the moderating variables for governing the human resource practices–employee competencies relationship.Practical implicationsSpecial focus can be placed on extensive custom in-house training and development activities. Proper division of work can be done for new employees and experienced employees depending upon their learning capabilities. The firms can do so by either implementing formal or informal organizational structures to achieve full gains. Firms should focus largely on narrowing the development practices adopted for diverse age groups of workforce population. The four practices proposed by the Organization for Economic Cooperation and Development (2006) for ensuring effectiveness of development practices and its impact on old age employee effectiveness and attitude should be put in practice.Originality/valueThe originality of this study lies in its exploration of the intricate interplay among age, gender and human resource practices in shaping employee competencies. By understanding how these factors interact within the human resource practices–employee competencies framework, this research offers a unique perspective on the evolving workforce dynamics. It goes beyond the conventional human resource management strategies to uncover nuanced insights, shedding light on tailored approaches that consider the specific needs and aspirations of diverse employees. This innovative perspective contributes to a more inclusive, efficient and adaptable work environment, enriching both the academic understanding of human resources and the practical implementation of strategies for contemporary organizations.
Curating the elegance of Chikankari: a case of Ada
Authors: Dwivedi Hemverna , Kumar Shubham 
Published: December 2023

Learning outcomes
Upon completion of the case study, the students will be able to conceptualize the importance of brand differentiation; suggest the implications of brand differentiation in the context of the traditional Chikan art form; examine the aspect of a brand’s product portfolio management; and critically analyse the competitive advantages of the brand using the VRIO framework.

Case overview/synopsis
The Chikankari art form gained worldwide recognition. In fact, it also received a geographical indication (GI) tag which is important for international branding. The case is centred around an entrepreneur, Mr. Vinod Punjabi, who redefined the essence of the existing Chikan art form by value addition in terms of intricate designs, patterns and exclusivity. He founded the brand Ada in 2015 aimed at preserving the traditional art form while curating elegance and exclusivity in its product portfolio. The case outlined Punjabi’s journey. The protagonist carefully analysed the open and unorganized Chikankari market and adopted the strategy of brand differentiation to stand apart from the competitors. Punjabi’s daughter, the chief operations officer of Ada, described the aspects. The journey was arduous, but over the years, Ada emerged as a successful name in the Chikankari market. The brand’s intent of becoming synonymous with Chikankari was successful owing to its authentic and exclusive hand-crafted products in the competitive environment of machine-made replicas. Furthermore, the brand also consistently worked on the aesthetic appearance of its store to attract a wide range of customers. Punjabi ensured that the brand was an amalgamation of all the essential elements for its survival in the long run.

Complexity academic level
The case is aimed for students pursuing bachelor’s and master’s degrees in business administration/diploma in management, marketing and entrepreneurship. Furthermore, it will assist the management trainees in gaining valuable insights.

Supplementary materials
Teaching notes are available for educators only.

Subject code
CSS 8: Marketing.
Quality analysis of range hood impeller automated assembly based on generalized grey relational degree
Authors: Xianglin M.A. , Cai Haochen , Yang Qiming , Wang Gang , Mao Kun 
Published: December 2023

PurposeThis paper establishes a quality model for automation assembly of range hood impeller based on generalized grey relational degree, it improves the debugging efficiency of the newly developed assembly workstation.Design/methodology/approachFirst, spot check the trial production impellers and obtain three indexes that reflect the assembly quality of the impellers. Then, analyze the parameters that affect the assembly quality of the impeller using grey relational analysis (GRA), establish a model for the assembly quality of the range hood impeller based on the generalized grey relational degree and identify the main parameters. After that, analyze the transmission structure of automation assembly workstation, identify the reasons that affect parameters and propose improvement plans. Finally, a trial production is conducted on the automation assembly workstation after adopting the improved plan to verify the quality model of impeller automation assembly.FindingsThe research shows that compared to manual assembly, the automation assembly quality of the impeller using GRA model has been improved, shortening the debugging cycle of the newly developed assembly workstation.Practical implicationsThe newly developed automation equipment will have some problems in the trial production stage, which often rely on the experience of engineers for debugging. In this paper, the automation assembly quality model of range hood impeller based on GRA is established, which can not only ensure the quality of finished impeller but also shorten the debugging cycle of the equipment. In addition, GRA can be widely used in the commissioning of other automation equipment.Originality/valueThis study has developed a set of impeller automation assembly workstation. The debugging method in the trial production stage is beneficial to shorten the trial production time and improve the economic benefits.
Functional or financial remedies? The effectiveness of recovery strategies after a data breach
Authors: Guo Yuanyuan , Wang Chaoyou , Chen Xiaoting 
Published: December 2023

PurposeThis study aims to examine the relative effectiveness of functional and financial remedies in influencing customers' negative coping responses in the event of a data breach. It also uncovers the different mediating roles played by customers' feelings of anger and fear in the process of data breach recovery. This study thus differs from the literature, which has primarily focused on the impact of financial compensation and apologies for service failures in face-to-face environments.Design/methodology/approachTwo scenario-based experiments were conducted to empirically validate the model. The authors received 302 copies of the questionnaire, of which 269 were valid.FindingsThis study finds that functional remedies are more effective than financial remedies when sensitive information has been compromised, but there is no significant difference between the effectiveness of the two remedies when nonsensitive information has been compromised. In addition, functional remedies influence negative coping behaviors directly and indirectly; the indirect effect is achieved through the reduction of fear and anger. Contrary to the authors' expectation, financial remedies do not have a direct effect on negative coping behaviors; they can indirectly affect negative coping behaviors by reducing anger but do not affect negative coping behaviors by reducing fear.Practical implicationsThis study provides key insights into how to manage customer reactions in the event of a data breach, suggesting the use of carefully designed recovery strategies. Companies must attend to customers' specific emotional responses to manage their negative coping behaviors.Originality/valueThis study extends the limited literature on data breach recovery actions by investigating the different effectiveness of functional and financial remedies in the event of a data breach. It also uncovers how functional and financial recovery strategies affect customers' negative coping behaviors by revealing the different mediating effects of fear and anger.
How does transformational leadership impact organizational unlearning: insights from persistence theories
Authors: Sharma Shubham , Lenka Usha 
Published: December 2023

PurposeEmpirical attempts to recommend enabling mechanisms for organizational unlearning are sparse and have almost neglected the vital role of leadership in transforming organizations through unlearning. Based on the tenets of persistence theories like path-dependence and imprinting theory, this study examines the relationship between transformational leadership and unlearning with the mediating role of knowledge sharing, transparent internal communication and intrapreneurship.Design/methodology/approachTo analyze the hypothesized relationship between these constructs, data were collected from 452 faculty members working in Centrally Funded Technical Institutions (CFTIs) in India. The data were analyzed using Process macro (Hayes, 2022).FindingsThe results show a significant effect of transformational leadership on organizational unlearning. This effect is mediated by transparent internal communication and intrapreneurship. However, knowledge sharing did not mediate the relationship between transformational leadership and organizational unlearning.Practical implicationsThe Fourth Industrial Revolution, Covid-19, the rise of generative artificial intelligence tools like ChatGPT and policy reforms have pushed higher educational institutions to transform by unlearning old practices and experimenting with new ones. This paper informs how educational institutions can initiate and sustain the unlearning process.Originality/valuePersistence theories like path-dependence and imprinting theory suggest that organizations often stick with proven success formulas and find it challenging to adopt new practices. Moreover, path dependence theorists advocate the role of an external intervening mechanism to break away from rigid and inefficient routines (or paths). This paper argues that in addition to external events (e.g. crisis, etc.), transformational leaders combined with organizational processes also help in unlearning obsolete knowledge and routines.
Client influence in property valuation in Nigeria: a valuer-banker perspective and fuzzy DEMATEL study
Authors: Adilieme Chibuikem Michael , Abidoye Rotimi Boluwatife , Lee Chyi Lin 
Published: December 2023

PurposeGiven the significant role played by valuers and the evidence of a lack of independence in some property valuation industries, particularly in emerging markets, this study analyses the issue of client influence in property valuation by providing a valuer-client perspective and measuring the interrelationships between the clients' influence factors to identify causal factors of prominence, which can assist in developing solutions to address the clients' influence issue.Design/methodology/approachThe study used a mixed-method approach. Firstly, interviews were conducted with ten property valuers and five financial institution staff in Nigeria, and the data were subject to thematic analysis using Nvivo 12 software. A matrix questionnaire survey was administered to the valuers, and the responses were analysed using the fuzzy Decision-Making Trial and Evaluation Laboratory (DEMATEL) method.FindingsThe results indicate that institutional clients, loan-seeking customers, property valuers and the perception of corruption within the Nigerian environment fuelled the issue of clients' influence. Based on the measurement of the interrelationship between the 14 identified client influence factors, the type of company, perception the public has of the industry, size of the firm, relationship with the client, type of client and regulatory framework were the factors of prominence.Practical implicationsThe findings of this study bear huge implications for Nigeria and other similar structured property markets facing the issue of clients' influence in property valuation. With the prominent factors bearing root in a mix of client, valuer and environmental factors such as the valuation structure, process and public perception, there is a need for solutions that level the playing field between institutional clients and valuers, reinforce transparency and establish excellent regulatory standards to address the issue of clients' influence.Originality/valueThis study is the first to measure the interrelationships between the clients' influence factors to identify the prominent causal factors. Accordingly, considering the multi-factors, the research is novel as it focusses on those factors that would likely lead to other factors, thereby providing opportunities to develop solutions that focus on those factors of prominence. Secondly, the study deviates from the narrative on clients' influence in property valuation, which pits it as solely a client or valuer factor, by showing how the interplay of the stakeholders' interests and the environment promotes the issue in a non-transparent property market.
A simulation of the macroeconomic effects of the Russia–Ukraine War on the Moroccan economy using the DSGE model
Authors: El Ouazzani Hicham , Ouakil Hicham , Moustabchir Abdelhamid 
Published: December 2023

AbstractRussia's invasion of Ukraine has had significant global economic implications, disrupting trade flows and leading to a rise in oil prices that has affected world economies, including Morocco. The aim of this study is to assess the impact of these external shocks on the Moroccan economy using a dynamic stochastic general equilibrium (DSGE) model, which enables detailed analysis of the interactions between various macroeconomic variables such as inflation, exchange rates and trade balances. The results of the study highlight the importance of taking risk premium shocks into account in economic policy‐making, as they can lead to higher inflation and a real depreciation of the Moroccan currency. The DSGE model provides a sound analytical framework for policy‐makers to assess and manage the impact of these external shocks on the Moroccan economy and thus promote economic stability and growth in the context of global economic uncertainty.