bluuebunny/crossref_metadata_2025_split huggingface dataset:
Long-term aerobic-resistance combined training improves health in young adult women by improving inflammatory mediators
Authors: Ihsan N. , Sugiharto S. , Goenawan H. , Kartiko C.D. , Okilanda A. , Merawati D. , Sepriadi S. , Sari A.K. , Pranoto A. 
Published: February 2025

Abstract
Obesity has become a global crisis, raising significant concerns about the future quality of human resources. Therefore, the development of effective management strategies for obesity remains a priority to mitigate its adverse impacts. This study aimed to demonstrate the long-term and consistent effects of aerobic-resistance combined training on improving the health of obese individuals by using inflammatory mediators as biomarkers to assess health quality. A total of 25 obese women aged 20-30 years were recruited and underwent an 8-week aerobic-resistance combined training intervention. ELISAs were used to evaluate the interleukin (IL)-6, tumour necrosis factor (TNF)-α, and IL-10 levels in all the samples. Statistical analysis techniques, including paired sample t tests and independent sample t tests, were applied with a significance level of 5%. The results revealed a significant reduction in the IL-6 and TNF-α levels and an increase in the IL-10 levels before and after aerobic-resistance combined training (). Additionally, we observed a reduction in the IL-6 and TNF-α levels and an increase in the IL-10 levels between the groups (). These findings indicate that long-term and consistent aerobic-resistance combined training is effective in improving inflammatory biomarkers, thus potentially serving as an effective therapeutic modality to reduce the negative impacts of obesity.
Probiotic enhanced immunity and mental wellbeing of generally healthy women: a randomised, placebo-controlled and double-blind study
Authors: Nisaa A.A. , Mageswary U. , Pei X. , Kadir M.N. , Oon C.-E. , Rajendran D. , Tan J.-J. , Roslan F.F. , Balasubramaniam S.D. , Sany S. , Ismail E.H.E. , Azizan A.S. , Liong M.-T. 
Published: February 2025

Abstract
The elucidation of the gut-brain axis underscores the critical role of probiotics in enhancing mental wellbeing through immunomodulatory mechanisms. We thus aimed to investigate the effects of a probiotic Lactiplantibacillus plantarum Probio87 (orally administered one sachet/day; 9 log cfu/sachet) or placebo for 12-weeks, on immunity and brain health, via possible mechanisms of inflammation and neurotransmitter functions in a generally healthy women population. A parallel, randomised, double-blind and placebo-controlled study was performed in generally healthy women (n = 112). Women were randomised to either the probiotic (n = 58, mean age 38.38 ± 0.85 years) or placebo (n = 54, mean age 38.91 ± 0.98 years) for 12-weeks. Immunity and mental wellbeing profiles were evaluated via questionnaires and blood gene expression profiles. Over the study period, the Probio87 group demonstrated a better impact on general women’s health as compared to the control group, as measured by the Women’s Health Questionnaire (WHQ), particularly in domains related to depressed mood, somatic symptoms, anxiety, sexual health, sleep, and menstrual health. The probiotic effects were exhibited later, typically after 6-weeks of intervention, taking over placebo effects that primarily faded off during early stages of the intervention. Regarding immunity, women in the Probio87 group exhibited upregulation of more immunity-related genes than those in the placebo group, primarily associated with NK cells and anti-inflammatory effects via IL-10. Additionally, Probio87 provided gut-brain axis benefits by enhancing the actions of neurotransmitters serotonin and GABA, while also balancing hunger and satiety. The probiotic Lactiplantibacillus plantarum Probio87 significantly improved general health, mood, anxiety, and sleep in a generally healthy women population over 12 weeks. It enhanced immune function through increased expression of immunity-related genes and positively modulated neurotransmitters involved in brain health. All these findings supported from our WHQ data, where the administration of probiotic improved domains related to depressed mood, anxiety, sexual behaviour and sleep problems.
The study is registered at ClinicalTrials.gov under identifier number: NCT05302687.
Gastrointestinal stability of Dipeptidyl peptidase IV (DPP-IV)-inhibitory peptides identified in Tenebrio molitor
Authors: Berraquero-Garcı́a C. , Garcı́a-Moreno P.J. , Pérez-Gálvez R. , Espejo-Carpio F.J. , Guadix E.M. 
Published: February 2025

Abstract
The use of insects recently emerged as an alternative source of high-quality protein for the obtention of peptides with a wide range of bioactivities, such as antidiabetic, while offering a more environmentally sustainable approach. However, antidiabetic DPP-IV inhibitory peptides are often rich in leucine, making them susceptible to degradation by pepsin and chymotrypsin during gastrointestinal digestion. This study uses bioinformatic prediction and in vitro activity assays to identify DPP-IV inhibitory peptides within the Tenebrio molitor proteome and assess their bioavailability. Conducting homology analysis, three peptides – ILAP, FLQP, and APVAH – were identified as complete matches, but efficient release of the sequences through targeted hydrolysis remains a significant challenge. Notably, a substantial decline in the DDP-IV inhibitory activity was found for the peptide fragments generated after digestion, compared to the original parent peptides. The inhibitory mechanisms of all three peptides were examined, revealing that mixed inhibition was associated with enhanced activity. Insect-derived peptides, such as APVAH with an IC50 of 0.013 ± 0.001 mg peptide/mL, may serve as effective DPP-IV inhibitors for diabetes management. However, protecting these peptides from gastrointestinal proteases is essential due to observed activity loss in digested fragments.
“I Am Chinese, Not Chinese”: Some Implications of an Ambiguity and Proposals for Alternatives
Authors: Shih Fang-long 
Published: February 2025

Abstract
Prompted by the meme, “我是華人不是中國人,” and playing on its (machine-) translation into English as “I am Chinese, not Chinese,” this article explores how in English the word “Chinese” ambiguates what are two separately named concepts in Chinese: 華人 (Huaren, referring to Chinese ethnicity) and 中國人 (Zhongguoren, referring to Chinese citizenship). Within the prc Firewall, the official designation is: 華人也是中國人, translated as Chinese are also Chinese), which co-implicates the two terms, endowing them with a singular, fixed, and primordialist sense. Beyond the Firewall, there are suggestions that 華人and 中國人should be recognized as separable terms, with 華人as a hybrid, hyphenated, and localized notion, indicative of some changing senses of identity. A new English coinage, Huabrid (華裔 Huayi) may help to encapsulate multiple and hybrid senses of how 華裔/Huayi/Chinese/Huabrid can be thought of as separable from 中國人/Zhongguoren/Chinese.
Cancer and Trauma Collide: Injury Patterns and Outcomes in the Pediatric Trauma Patient With Cancer
Authors: Sullivan Brittany , Schomberg John , Haduong Josephine , Bose Sourav K. , Guner Yigit S. , Giron Andreina , Gholizadeh Maryam , Yu Peter T. 
Published: February 2025

Purpose There is a lack of data regarding pediatric trauma patients with a cancer diagnosis. The purpose of our study is to analyze demographics, ED admissions, procedures, and characteristics pertaining to this population. Methods The NTDB database was queried from 2007 to 2022. This study collected 1,726,681 trauma admissions ≤18. Of these patients, 397 were identified with a cancer diagnosis and had received chemotherapy within 30 days of their trauma admission. Results The median age of trauma patients with cancer was 9 years old vs 12 years old for non-cancer patients ( P = 0.14), but cancer patients had a longer length of stay compared to patients without a cancer diagnosis (4.3 +/− 10 vs 3 +/− 5.7, P < 0.001). Conclusion We conclude that pediatric trauma patients with a cancer diagnosis had a longer length of stay despite a similar injury severity score, were less likely to sustain spinal cord injuries, but more likely to receive transfusions when compared to non-cancer trauma patients. There is need for further research regarding traumatic injuries in this patient population.
An electronic pre-visit agenda-setting questionnaire in ambulatory palliative care is feasible and acceptable to patients, care partners, and clinicians: A mixed methods evaluation
Authors: Wilson Matthew M , Broglio Kathleen , Vergo Maxwell T , Barnato Amber E , Cullinan Amelia M , Doherty Julie R , King Joel R , Devito Anna Marie , Holmes Anne B , Hinson Jennifer J , Holt Kimberley R , Holthoff Megan M , Kobin Emily G , Legere Alaina R , Nelson Eugene C , O’Donnell Elizabeth A , Saunders Catherine H , Tomlin Stephanie C , Kirkland Kathryn B , Van Citters Aricca D 
Published: February 2025

Background: To provide patient-centered healthcare for people with serious illness, healthcare teams must elicit needs, goals, preferences, and values from patients and care partners. Aim: Describe feasibility and acceptability of an electronic pre-visit agenda-setting questionnaire for patients and care partners to identify these topics before ambulatory palliative care visits. Design: Concurrent mixed-methods formative evaluation of questionnaire feasibility and acceptability. We extracted questionnaire responses and patient characteristics from electronic health records and sent anonymous post-visit patient experience surveys. Researchers conducted thematic analysis on semi-structured interviews with participants. Setting/participants: Patient participants had an active patient portal account and ambulatory visit at a free-standing palliative care clinic in a tertiary academic medical center in rural Northeastern United States between June 2021 and March 2023. Clinic staff included physicians, nurse practitioner, social worker, nurses, and scheduling secretary. Most visits were conducted via video or telephone. Results: Completion rate was 50% for pre-visit questionnaires (2107 of 4204 visits). Patients completing post-visit surveys (following 859 visits) reported the pre-visit questionnaire was easy to complete (75%) and helped their conversations with clinicians (79%). Patients who believed their clinician reviewed their responses rated shared decision-making higher (82%) than those who did not (59%). Semi-structured interviews with five patients, two care partners, and seven clinicians identified four themes: the questionnaire engages patients in pre-visit planning, incorporates care partners into the care team, facilitates care for the care partner, and improves perceived efficiency and care quality. Conclusions: An electronic pre-visit questionnaire was feasible and acceptable in ambulatory palliative care visits.
Skin of Colour Education Initiatives Among Dermatology Residents: A Narrative Review
Authors: Dienes Serena , Seeburruth Darshana , Park Ye-Jean , Sachdeva Muskaan , Joseph Marissa , Hanna Sameh 
Published: February 2025

Background: Achieving comprehensive education in skin of colour (SoC) dermatology presents a multifaceted challenge for dermatology trainees. Exposure to diverse skin tones in didactic curricula and clinical encounters varies greatly based on geographic location and institution and, as a whole, remains disparate. While SoC education initiatives for medical students and residents have increased in recent years, the characteristics and outcomes of initiatives specifically tailored to dermatology residents have not been summarized. Objectives: (1) Outline the demographic features of participants; (2) summarize intervention characteristics and the metrics by which educational impact was defined. Methods: MEDLINE, Embase, and PubMed were searched for SoC education interventions aimed at dermatology trainees. Results: Five studies were selected for inclusion. Two hundred thirty-seven dermatology residents participated from institutions across the United States, United Kingdom, Australia, and Botswana. Most interventions were didactics based, assessed changes in subjective confidence, and employed identical pre- and posttest questions. Confidence increased for didactic-only interventions, decreased with multimodal interventions, and was incongruent with objective knowledge or diagnostic scores. Single-format interventions or assessments with identical pre- and posttest questions may provide an inflated sense of confidence through recall bias or other heuristics. Conversely, the cognitive synthesis afforded by multimodal interventions or new (but equivalent) assessment questions may lead to low confidence ratings despite improved knowledge scores. Conclusions: When designing SoC learning initiatives in postgraduate dermatology education, multimodal formats, and paired objective and subjective assessments that employ both identical and different pre- and post-intervention questions may give a more relevant and accurate reflection of impact in clinical practice settings.
Evaluating staff views and understanding of the crisis and home treatment service (CAHTS): A mixed-methods study within the child and adolescent mental health service (CAMHS)
Authors: Kusnierczak Paulina , Payne Naomi , Reynolds Megan , Williams Natasha 
Published: February 2025

Background The number of children and young people (CYP) experiencing mental health crises in the UK is increasing. The NHS Long Term Plan (2019) prioritises crisis care for CYP. There is a lack of research and understanding into staff views and understandings of these services. The Crisis and Home Treatment Service (CAHTS) is a service within Child and Adolescent Mental Health Services (CAMHS) across Bath and Northeast Somerset, Swindon, and Wiltshire (BSW) and is a key component of the crisis mental health care for CYP. The aims of this study were to gain an insight into staff’s views and understandings of the CAHTS, and to explore and identify areas for improvement for future practice and policy for the CAHTS. Methods The study employed a mixed-methods design, obtaining quantitative and qualitative data, by distributing online surveys ( n = 37) and semi-structured interviews ( n = 9) to gather staff views and understandings. Participants were recruited by opportunistic sampling. Interviews were recorded and transcribed, and a thematic analysis was undertaken. Results Participants ‘agreed’ that CAHTS were acting in accordance with their core principles and were ‘highly likely’ to use the service in the future. The thematic analysis revealed seven themes, the four most dominant themes identified were: good qualities of the CAHT service, working collaboratively, good clinician skills and understaffed for demand. Conclusions The data provides insight into staff’s views and understandings of the CAHTS. From the themes derived, the study identified various implications for the CAHTS including further training for staff.
Satisfaction with friendship support protects autistic youth from the negative effects of peer victimization
Authors: Libster Natalie , Adams Ryan , Bishop Somer , Zheng Shuting , Taylor Julie Lounds 
Published: February 2025

Autistic youth experience higher rates of peer victimization than their non-autistic peers. While there is some evidence that friendships may protect against the negative mental health effects of peer victimization in the general population, these protective effects have not been examined in autistic youth. The current study explored whether satisfaction with friendship support is associated with depressive symptoms among autistic youth, and whether satisfaction with friendship support buffers against the negative effects of peer victimization on mental health. Autistic youth ( N = 224) between the ages of 15 and 25 years ( M = 18.68 years) completed questionnaires measuring frequency of peer victimization, satisfaction with friendship support, and depressive symptoms. Satisfaction with friendship support was not associated with depressive symptoms; however, the effect of peer victimization on depressive symptoms was attenuated for youth who were more satisfied with their friendship support compared to youth who were less satisfied with their friendship support. The results of the current study therefore highlight the potential for promoting mental health of autistic youth through reducing peer victimization and increasing satisfaction with peer relationships. Lay Abstract Autistic youth are more likely to be bullied than youth who are not on the autism spectrum. Youth in the general population who are bullied experience poor mental health, but those who are satisfied with their friendships may be protected from these negative outcomes. No studies have looked at how friendships affect the mental health of autistic youth who are bullied by their peers. Autistic youth completed questionnaires that asked them to report how frequently they were bullied, whether they were satisfied with the support they received from friends, and depressive symptoms they experienced. Depressive symptoms did not differ between youth who were more satisfied and youth who were less satisfied with their friendship support. However, among youth who were frequently bullied, depressive symptoms were lower for those who were more satisfied with their friendship support compared to those who were less satisfied with their friendship support. This study shows that interventions are needed to support the mental health of autistic youth by decreasing bullying by peers and increasing positive peer relationships.
Evaluation of the E-Psycho-Oncological Short-Term Intervention “By Your Side” to Reduce Cancer-Related Distress: A Pilot Study
Authors: Strunk Sven Erik , Graf Johanna , Krakowczyk Julia Barbara , Wieser Alexandra , Heinen Jana , Schug, PhD Caterina , Jahre Lisa Maria , Skoda Eva-Maria , Erim Yesim , Teufel Martin , Bäuerle Alexander 
Published: February 2025

Objective: A large number of patients with cancer experience distress, but not all of them receive adequate psychological support. The e-psycho-oncological short-term intervention “By your Side” was developed to offer evidence-based and low-threshold support for cancer patients dealing with distress. Methods: A longitudinal intervention pilot study was conducted from 4 March 2022 to 4 January 2023. N = 91 participants took part in the study. N = 82 completed the first module, while n = 23 successfully completed the whole intervention and were included in the final data analyses. “By your Side” consists of 16 modules based on cognitive behavioral therapy, acceptance and commitment therapy and mindfulness-based stress reduction. Differences in distress between the baseline (T0), post-intervention (T1), and follow-up (T2) were analyzed using an ANCOVA and post-hoc t-tests. Secondary outcomes (anxiety, depression, mindfulness, and self-efficacy) were also compared between measuring points, using ANOVAs and post-hoc tests. Results: A significant reduction ( padj = 0.014, d = 0.654) in distress from baseline (T0, M = 52.68, SD = 16.34) to follow-up (T2, M = 43.84, SD = 17.59) was observed. There was a significant decrease in anxiety symptoms and a significant increase in mindfulness and self-efficacy. The user’s satisfaction ( M = 28.00, range 8-32) and the usability ( M = 89.57, range 0-100) of the intervention were high. Conclusion: The study provides preliminary evidence that the e-psycho-oncological short-term intervention “By your Side” can successfully reduce the distress of cancer patients. The high dropout rate (74.7%) must be taken into account. Trial registration: German Clinical Trial Register ( https://www.drks.de/search/de/trial/DRKS00036001 ), DRKS number: 00036001 (retrospectively registered)
Comparison of treatment efficacy and cost-effectiveness of rituximab and oral agents among patients with neuromyelitis optica spectrum disorders: a population-based cohort study
Authors: Lee Hye Lim , Kang Minwoong , Seok Jin Myoung , Kim Byung-Jo , Kim Byoung Joon 
Published: February 2025

Background: Rituximab (RTX) is a well-known effective treatment for neuromyelitis optica spectrum disorder (NMOSD). Aims: To investigate the effectiveness of RTX treatment in patients with NMOSD and compared medical expenses between RTX and other oral agents. Methods: Using data from the National Health Insurance System database (2010−2021), we compared the time to the first relapse and medical expenses after each medication between groups with RTX and oral agents. Also, we analyzed the association between the level of disability and the type of drugs. Results: A total of 899 patients were included, and they were divided into two groups according to the type of treatment. The group treated with RTX had a lower risk of relapse than those treated with other oral agents (hazard ratio, 0.479, p < 0.001). Regarding medical expenses, the increase in total medical costs was associated with the use of RTX and the number of relapses. The increase in medical costs was higher in cases with increased disability owing to NMOSD after adjustment for the number of relapses. Conclusion: In comparison to other oral agents, RTX showed a favorable treatment effect. It is also relatively cost-effective, considering the change in disability in a large-scale real-world nationwide study.
Health behaviours of 17- to 19-year olds in North East England: assessing adherence to current recommendations for young people at the adolescent-adult boundary
Authors: Basterfield L , Rowland M , Rigg R , Reilly JJ , Janssen X , Pearce MS , Evans EH , Adamson AJ 
Published: February 2025

Aims: Late adolescence/young adulthood represents a transition to independence, with increasing control over health behaviours (HB). However, HB data of late adolescents are often reported in wide and inconsistent age brackets, making comparisons with age-targeted guidelines difficult. We aimed to characterise important HB (body composition, physical activity (PA), diet) of late adolescents from North East England. Methods: A total of 145 17- to 19-year olds from the Gateshead Millennium Study birth cohort participated in 2017 to 2018. Measurements including height, weight, body fat, accelerometer-measured PA and sedentary behaviour, and 24-hour dietary recall were taken. Comparisons with current global age-appropriate recommendations were made for four variables: (1) 60 min moderate-vigorous intensity PA (MVPA)/day (age 17 years old) or 150 min MVPA/week (18- to 19-years old); (2) body fat (<25% for males, <30% for females); (3) free sugars <5% total energy intake; (4) five portions fruit and/or vegetables/day. Results: Most recommendations were not met: MVPA averaged 37 min/day, 20% of 17-year olds met 60 min/d, and 55% of 18- to 19-year olds met 150 min/week. About 26.5% of participants had excess body fat. Daily fruit/vegetable consumption was 2.7 portions; 12% consumed ‘5-a-day’ portions of fruit and/or vegetables, 13.5% consumed <5% energy from free sugars. Together, 43% of participants met 0/4, 44% met 1/4%, and 0% met 4/4 age-appropriate health recommendations. Conclusion: These novel empirical data reveal concerning HB in this population of late adolescents, suggesting targeted health messaging to improve HB is needed.