bluuebunny/crossref_metadata_2025_split huggingface dataset:
Patient delay in initiating treatment after breast cancer diagnosis: A cause for concern
Authors: Gbenga Olaogun Julius , Sulaiman Agodirin Olayide , Bamidele Idowu David 
Published: February 2024

Objectives
Delayed presentation, diagnosis, and treatment negatively impact the survival of breast cancer patients. This study aimed to describe the time to initiation of treatment after breast cancer diagnosis and causes of delay to help identify targets for future interventions.

Material and Methods
A prospective study was carried out on breast cancer patients who had delay initiating two major oncologic treatments (chemotherapy and mastectomy) between July 2018 and June 2021. Data were analyzed by SPSS version 23.0.

Results
Sixty-two of 146 patients (42.5%) delayed initiating oncologic treatments. All patients were females, and their ages ranged from 21 to 70 years, with a median age of 48 years (mean 46.9 ± 10.3 years). Median durations of symptoms at presentation and between diagnosis and commencement of treatments were 6 and 10 months, respectively. The mean lump size at presentation and before treatment were 8.2 cm and 15.4 cm, respectively. Early versus advanced breast cancer was 21 (33.8%) vs. 41 (66.1%) at presentation and 2 (3.2%) vs. 60 (96.8%) before treatment. Major reasons for delayed treatment include the use of alternative therapy (48.4%), financial problems (24.2%), fear of surgery (9.7%), chemotherapy side effects (8.1%), and family interference (4.8%). The length of delay was not affected by the patient’s age, marital status, or level of education (p > 0.05).

Conclusion
Patients had longer delays in initiating treatments after breast cancer diagnosis. Focusing on causes of secondary patient delay is equally as important as early detection and diagnosis.
Workplace design in Indonesian manufacturing small and medium-sized enterprises: Review and further research
Authors: Herwanto Dene , Suzianti Amalia , Komarudin Komarudin 
Published: February 2024

Abstract
Workplace design is an essential process for the manufacturing industry to realize a low manufacturing cost with high productivity and competitive advantage, as well as high employee performance and well-being. Although research on workplace design in the Indonesian manufacturing industry began more than 20 years ago, workplace conditions in the manufacturing industry, especially in small and medium-sized enterprises (SMEs) in Indonesia, have remained subpar, with high material handling costs. This review article aims to evaluate recent research on workplace design in the Indonesian manufacturing SMEs and explore possible directions for further research. The results of this review indicate that the research on workplace design in Indonesian manufacturing SMEs is mostly focused on the department area (micro-level), using systematic layout planning methods to improve material handling activities. Even though environmental conditions are unfavorable with low levels of occupational safety and health, research that consider these two in the process of designing workplace in Indonesian manufacturing SMEs is still limited. This review also shows the possibility of developing an integrated workplace design by involving environmental ergonomics and occupational safety and health in manufacturing SMEs.
Application of Kaizen and Kaizen Costing in SMEs
Authors: Biadacz Renata 
Published: February 2024

Abstract
The research problem revolves around an attempt to answer the questions: “Are enterprises from the SME sector interested in implementing strategic management accounting instruments, including Kaizen Costing? Is Kaizen Costing more widely used in SMEs operating in Poland?" The aim of the article is therefore to highlight the importance of Kaizen and Kaizen Costing and to draw attention to how much support these solutions can be for SMEs in the current social, economic, and environmental conditions. The article presents the results of surveys conducted in this regard.
The accomplishment of the established objective of the work required conducting a review of the literature on the subject and presenting conclusions from previous own research in the above respect. The method of participant observation, critical analysis and synthesis was used in the study.
According to the research results, there is little interest in these instruments in large enterprises, however, in medium-sized enterprises, the interest and degree of application of Kaizen and Kaizen Costing is negligible. The research results indicate the need for further development and broadening the dialogue on the usability and benefits which enterprises, in particular SMEs, may derive from the introduction of such innovative solutions.
Efficacy of a Psychologically-Informed Physiotherapy Intervention in Patients with Chronic Low Back Pain at High Risk of Poor Prognosis: A Pilot and Feasibility Randomized Controlled Trial
Authors: Desgagnés Amélie , Côté-Picard Claudia , Gaumond Alain , Langevin Pierre , Piché Mathieu , Pagé Gabrielle , Pinard Anne-Marie , Tousignant-Laflamme Yannick , Massé-Alarie Hugo 
Published: February 2024

Purpose: To determine the feasibility of a randomized controlled trial (RCT) testing the efficacy of psychologically-informed physiotherapy (PIPT), which includes usual physiotherapy (UP) interventions, compared with UP, and to explore the preliminary effectiveness of the interventions. Method: People with chronic low back pain at high risk of poor prognosis (using the STarT Back screening tool) were recruited and allocated to PIPT or UP. Effectiveness of recruitment strategies, adherence to intervention, risk of contamination, and specific challenges were assessed. Functional capacity, pain, quality of life, kinesiophobia, catastrophization, central sensitization, and self-efficacy were measured at baseline, 6-, 12- and 24-week follow-ups. Results: Forty participants were recruited mainly by diffusing through Laval University’s email list, and 10 physiotherapists treated the participants recruited. The retention rate of participants at 24 weeks was 72.5%. Adherence to treatment by participants and physiotherapists was very good. The risk of contamination was low, and the specific challenges identified were modifiable. Significant improvement over time in all clinical variables of interest, except self-efficacy, was observed with no difference between groups. Conclusions: As most success criteria were met, conducting an RCT evaluating PIPT and PU is feasible with modifications. PIPT and UP appear to be similarly effective.
Porous films (Scaffolds) for cell growing
Authors: LOLADZE Tamar , KEBADZE Nino 
Published: February 2024

We have obtained the biodegradable, bio-compatible scaffolds (base-film for cell growing) possessing well developed porous surface made of polyester amide 8-Phe-6 (poly-mer composed of sebacic, L phenylalanine and 1,6 – hexanediol). Porous films were ob-tained by ultrasonic or mechanical dispersion of two-phase system (water/biodegradable polyester amide solution in chloroform), followed by freezing of the obtained emulsion and subsequent freeze-drying.
Development of Method of Multifunctional Personnel Assessment Using a Topsis Method
Authors: BASHELEISHVILI Irakli 
Published: February 2024

The paper offers the method of multifunctional personnel assessment, with the purpose of drawing a matrix of functional capabilities of multifunctional personnel, based on which we can carry out optimal selection of personnel and allocation of functions. The developed method of multifunctional personnel assessment uses a multi-criteria expert method - a TOPSIS method.
Keywords: Multifunctional personnel, matrix of functional capacities, decision matrix, TOPSIS, decision making method.
Дискретизация решений уравнений Пуассона по неточной информации
Authors: Арыстангаликызы Акмарал 
Published: February 2024

Уравнения в частных производных наряду с функцией, производной, интегралом относятся к основным математическим моделям. Их решения, даже в случае явного выражения посредством рядов или интегралов, фактически опять же представляют собой недоступные к прямым компьютерным вычислениям бесконечные объекты. Здесь снова визникает задача приближения конечными объектами, математическая формулировка которой соержится в определении Компьютерного (вычислительного) поперечника.
В статье изучается задача дискретизации решений уравнения Пуассона с правой частью $f$ из анизотропных классов Коробова $E^{r_1,...,r_s}$ по неточной информации. Получены оценки сверху погрешности в равномерной метрике дискретизации по информации, составляющих значения функции $f$ в точках, вычисленных с ошибкой. При этом указаны границы неточности информации, сохряняющие порядки убывания погрешности восстановления, вычисленных по неточной информации. Вычислительные агрегаты построены по оптимальным квадратурным формулам Коробова с равными весами и узлами, основанным на теории дивизоров алгоритмам.
KOMUNIKASI ANTAR LEMBAGA DAN DISEMINASI INFORMASI KPU DAN BAWASLU DALAM MESUKSESKAN PEMILU 2024
Authors: Tambun Frien Jones , Zebua Frendianus J R , Tambun Amsal Franky H 
Published: February 2024

Penyelenggaran Pemilu 2024 memiliki tantangan yang kompleks berkaitan dengan pelaksaaan pemilihan serentak di tahun yang sama dan tahapan panjang pemilihan. KPU dan Bawaslu adalah dua lembaga penyelenggara pemilu yang bertanggung jawab dalam lancarnya proses pemilihan, jumlah partisipasi politik serta pemilu yang langsung, umum, bebas, rahasia, jujur, dan adil. Secara kelembagaan KPU dan Bawaslu adalah mitra dalam penyelenggaraan pemilihan sehingga komunikasi antar kelembagaan dalam bentuk diseminasi informasi menjadi sangat penting melalui peningkatan partisipasi pemilih serta mempertahankan kepercayaan masyarakat akan pemilu berintegritas. Penelitian ini bertujuan memaparkan diseminasi informasi menjadi bagian penting KPU dan Bawaslu memperkuat komunikasi dalam upaya memperkuat peran dan profesionalisme lembaga penyelenggara Pemilu. Metode penelitian ini adalah kualitatif dengan analisis deskriftif. Adapun hasil penelitian ini menjelaskan memperkuat peran kelembagaan, kemitraan komunikasi antara KPU dan Bawaslu dan komunikasi krisis yang dilakukan penyelenggaraan Pemilu dalam rangka diseminasi informasi.
kata kunci : diseminasi informasi, penyelenggara pemilu, pemilu 2024, komunikasi krisis
Pengaruh Pembiasaan Morning Activity Terhadap Pembentukan Karakter Religius Siswa Kelas X danXI Di SMA Plus Islamic Village Integrated Islamic School
Authors: Fancha Rizka Fathya , Budiana Irma 
Published: February 2024

This research aimed to discover the effect of habituation of morning activity carried out routinely before starting teaching and learning activities in the mornings in forming religious character in class X and XI students at Islamic Village Plus Integrated Islamic School Senior High School. This examine used a descriptive quantitative correlational type. The study subjects were students of classes X and XI of Islamic Village Plus Integrated Islamic School Senior High School, totalling 130 students. The inquiry applied a random cluster sampling technique, and data collection techniques utilised observation, questionnaires and documentation. The validity result adopted the Pearson Product Moment correlation technique and the Cronbach Alpha Reliability Test with the help of SPSS 26. The data analysis used a simple linear regression technique and the Pearson Product Moment correlation. The results indicated a positive effect of habituation of morning activity on forming students' religious character at Islamic Village Plus Integrated Islamic School Senior High School. This can be seen from the acquisition of the t value is 13,45. In comparison, the t table is 1,97, with a significance level is < 0,05. The criteria H0Â is rejected if t valueÂ ËƒÂ t table at Î± = 5% with a value is 13,45 > 1,97. This means that the contribution of the variable X (Morning Activity Habituation) with the variable Y (Formation of Students' Religious Character) is 58.6%, and the difference is 41.4% which was not examined in this study.
Pengaruh Model Project Based Learning Terhadap Motivasi Belajar Siswa
Authors: Maesaroh Siti 
Published: February 2024

This research is to know theÂ impact of model project-based learning on students learning motivation for religion subjects. The research was done in SMK Islamic Village Tangerang. And the subjects for this research was gradeÂ XI total population number of 106 while the number of samples were 52 students. this research used quantitative method with correlation techniques to know two variable relations. While the technicnique to collect data was done by: questionnaires, interviews, and documentation. Data analysis used descriptive statistic analysis analysis whice is aimed to examine the hypothesis which is alreadydefined. The results of study showed that there was a positif impact between project-based learning on student learning motivation for religion subject that is a big as 24.4% students in grade XI inÂ SMK Islamic Village Tangerang. While anotherÂ 75.6% is influenced by other factors, those are teachers, friends, environment, family, and other factors that influences learning motivation.
Characterization of bacterial diversity and screening of cellulose-degrading bacteria in the gut system of Glenea cantor (Fabricius) larvae
Authors: Su Ran-Ran , Pan Bi-Qiong , Luo You-Xi , Zheng Xia-Lin , Lu Wen , Wang Xiao-Yun 
Published: February 2024

The intestinal bacteria of longhorn beetles would be ideal targets for pest control and lignocellulosic resources by destroying or exploiting their cellulose-degrading function. This article aims to investigate the diversity and community structure of intestinal bacteria the oligophagous longhorn beetle Glenea cantor. Additionally, it seeks to identify the presence of lignocellulose-degrading bacteria in the gut, and explore their role in consuming host kapok trees Bombax malabaricum. In this study, the bacterial community from G. cantor was examined by Illumina sequencing of 16S ribosomal RNA (rRNA) targeting the V3 and V4 regions. A total of 563,201 valid sequences and 814 OTUs were obtained. The dominant phyla were Proteobacteria, and the dominant genera were Acinetobacter and Lactococcus. The analysis of microbial diversity revealed a high bacterial diversity in the samples, with the gut bacteria playing a crucial role in the physiological activities of the host, particularly, 9 genera of intestinal bacteria with cellulose degradation function were found, highlighting their vital role in cellulose degradation. Five strains of cellulose-degrading bacteria, belonging to the genus Pseudomonas, were obtained from the intestinal tract of G. cantor larvae using traditional isolation and culture techniques as well as 16S rDNA sequencing. Among these strains, A4 exhibited a cellulase activity of 94.42 ± 0.42 U/mL, while A5 displayed the highest filter paper enzyme activity of 127.46 ± 3.54 U/mL. These results offered valuable insights into potential targets for pest control through internal attack digestion and cellulose-degrading bacteria in longhorn beetles.
Oral infectivity through carnivorism in murine model of Trypanosoma cruzi infection
Authors: Torres Víctor , Contreras Víctor , Gutiérrez Bessy , San Francisco Juan , Catalán Alejandro , Vega José Luis , Moon Kyung-Mee , Foster Leonard J. , de Almeida Rafael F. , Kalergis Alexis M. , González Jorge 
Published: February 2024

IntroductionOral transmission of T. cruzi is probably the most frequent transmission mechanism in wild animals. This observation led to the hypothesis that consuming raw or undercooked meat from animals infected with T. cruzi may be responsible for transmitting the infection. Therefore, the general objective of this study was to investigate host-pathogen interactions between the parasite and gastric mucosa and the role of meat consumption from infected animals in the oral transmission of T. cruzi.MethodsCell infectivity assays were performed on AGS cells in the presence or absence of mucin, and the roles of pepsin and acidic pH were determined. Moreover, groups of five female Balb/c mice were fed with muscle tissue obtained from mice in the acute phase of infection by the clone H510 C8C3hvir of T. cruzi, and the infection of the fed mice was monitored by a parasitemia curve. Similarly, we assessed the infective capacity of T. cruzi trypomastigotes and amastigotes by infecting groups of five mice Balb/c females, which were infected orally using a nasogastric probe, and the infection was monitored by a parasitemia curve. Finally, different trypomastigote and amastigote inoculums were used to determine their infective capacities. Adhesion assays of T. cruzi proteins to AGS stomach cells were performed, and the adhered proteins were detected by western blotting using monoclonal or polyclonal antibodies and by LC-MS/MS and bioinformatics analysis. ResultsTrypomastigote migration in the presence of mucin was reduced by approximately 30%, whereas in the presence of mucin and pepsin at pH 3.5, only a small proportion of parasites were able to migrate (∼6%). Similarly, the ability of TCTs to infect AGS cells in the presence of mucin is reduced by approximately 20%. In all cases, 60–100% of the animals were fed meat from mice infected in the acute phase or infected with trypomastigotes or amastigotes developed high parasitemia, and 80% died around day 40 post-infection. The adhesion assay showed that cruzipain is a molecule of trypomastigotes and amastigotes that binds to AGS cells. LC-MS/MS and bioinformatics analysis, also confirmed that transialidase, cysteine proteinases, and gp63 may be involved in TCTs attachment or invasion of human stomach cells because they can potentially interact with different proteins in the human stomach mucosa. In addition, several human gastric mucins have cysteine protease cleavage sites. DiscussionThen, under our experimental conditions, consuming meat from infected animals in the acute phase allows the T. cruzi infection. Similarly, trypomastigotes and amastigotes could infect mice when administered orally, whereas cysteinyl proteinases and trans-sialidase appear to be relevant molecules in this infective process.
Prevalence and prognostic implications of myocardial injury across different waves of COVID-19
Authors: Peiró Óscar M. , Delgado-Cornejo Juan R. , Sánchez-Giménez Raúl , del-Moral-Ronda Víctor , Lal-Trehan Nisha , Rocamora-Horrach Mar , Carrasquer Anna , Peraire Joaquim , Fort-Gallifa Isabel , Bardaji Alfredo 
Published: February 2024

IntroductionThe prognostic ability of myocardial injury across different waves of the COVID-19 pandemic is not well established. The purpose of this study was to evaluate the prevalence and prognostic implications of myocardial injury in the first and sixth wave of COVID-19.MethodsWe conducted a retrospective observational study that included patients admitted to the emergency department with COVID-19 with data on concentrations of cardiac troponin during the first and sixth wave. We compared the prevalence of myocardial injury and its predictive capacity for 30-day all-cause death in both waves.Results and discussionA total of 346 patients were included (1st wave 199 and 6th wave 147 patients). The prevalence of myocardial injury was 21% with non-significant differences between waves. Myocardial injury was associated, in both waves, with a higher prevalence of comorbidities and with an increased risk of 30-day all-cause death [1st wave HR: 3.73 (1.84–7.55); p &lt; 0.001 and 6th wave HR: 3.13 (1.23–7.92); p = 0.016], with non-significant differences in predictive capacity between groups after ROC curve analysis [AUC: 1st wave 0.829 (95% CI: 0.764–0.895) and 6th wave 0.794 (95% CI: 0.711–0.876)]. As limitations, this is a retrospective study with a relatively small simple size and troponin assay was performed at the discretion of the emergency physician so selection bias could be present. In conclusion, the prevalence of myocardial injury and its prognostic capacity was similar in both waves despite vaccination programs. Myocardial injury predicts short-term mortality in all COVID-19 patients, so they should be treated intensively.
Association of sleep traits with male fertility: a two-sample Mendelian randomization study
Authors: Lu Shikuan , Ma Ziyang , Zhou Wanzhen , Zeng Hongsen , Ma Jian , Deng Hang , Zhang Peihai 
Published: February 2024

Background: Previous observational studies have investigated the association between sleep-related traits and male fertility; however, conclusive evidence of a causal connection is lacking. This study aimed to explore the causal relationship between sleep and male fertility using Mendelian randomisation.Methods: Eight sleep-related traits (chronotype, sleep duration, insomnia, snoring, dozing, daytime nap, oversleeping, and undersleeping) and three descriptors representing male fertility (male infertility, abnormal sperm, and bioavailable testosterone levels) were selected from published Genome-Wide Association Studies. The causal relationship between sleep-related traits and male fertility was evaluated using multiple methods, including inverse variance weighting (IVW), weighted median, Mendelian randomisation-Egger, weighted model, and simple model through two-sample Mendelian randomisation analysis. Mendelian randomisation-Egger regression was used to assess pleiotropy, Cochrane’s Q test was employed to detect heterogeneity, and a leave-one-out sensitivity analysis was conducted.Results: Genetically-predicted chronotype (IVW,OR = 1.07; 95%CL = 1.04–1.12; p = 0.0002) was suggestively associated with bioavailable testosterone levels. However, using the IVW method, we found no evidence of a causal association between other sleep traits and male fertility.Conclusion: This study found that chronotype affects testosterone secretion levels. However, further studies are needed to explain this mechanism.
Dynamics of SARS-CoV-2 immunity after vaccination and breakthrough infection in rituximab-treated rheumatoid arthritis patients: a prospective cohort study
Authors: Kared Hassen , Jyssum Ingrid , Alirezaylavasani Amin , Egner Ingrid M. , The Tran Trung , Tietze Lisa , Lund Katrine Persgård , Tveter Anne Therese , Provan Sella A. , Ørbo Hilde , Haavardsholm Espen A. , Vaage John Torgils , Jørgensen Kristin , Syversen Silje Watterdal , Lund-Johansen Fridtjof , Goll Guro Løvik , Munthe Ludvig A. 
Published: February 2024

BackgroundSARS-CoV-2 vaccination in rheumatoid arthritis (RA) patients treated with B cell-depleting drugs induced limited seroconversion but robust cellular response. We aimed to document specific T and B cell immunity in response to vaccine booster doses and breakthrough infection (BTI).MethodsWe included 76 RA patients treated with rituximab who received up to four SARS-CoV-2 vaccine doses or three doses plus BTI, in addition to vaccinated healthy donors (HD) and control patients treated with tumor necrosis factor inhibitor (TNFi). We quantified anti-SARS-CoV-2 receptor-binding domain (RBD) Spike IgG, anti-nucleocapsid (NC) IgG, 92 circulating inflammatory proteins, Spike-binding B cells, and Spike-specific T cells along with comprehensive high-dimensional phenotyping and functional assays.FindingsThe time since the last rituximab infusion, persistent inflammation, and age were associated with the anti-SARS-CoV-2 RBD IgG seroconversion. The vaccine-elicited serological response was accompanied by an incomplete induction of peripheral Spike-specific memory B cells but occurred independently of T cell responses. Vaccine- and BTI-elicited cellular immunity was similar between RA and HD ex vivo in terms of frequency or phenotype of Spike-specific cytotoxic T cells and in vitro in terms of the functionality and differentiation profile of Spike-specific T cells.InterpretationSARS-CoV-2 vaccination in RA can induce persistent effector T-cell responses that are reactivated by BTI. Paused rituximab medication allowed serological responses after a booster dose (D4), especially in RA with lower inflammation, enabling efficient humoral and cellular immunity after BTI, and contributed overall to the development of potential durable immunity.