bluuebunny/crossref_metadata_2025_split huggingface dataset:
Comparative study on gene expression in psoriatic lesions versus chronic wound healing processes
Authors: Qiong Zhang , Dongxue Fu , Qing Zhang , Yukun Ren , Yuepeng An 
Published: November 2023

AbstractPsoriasis and chronic ulcers not only significantly impair quality of life but also pose a challenge in dermatological treatment. This study aimed to identify new therapeutic targets and biomarkers for psoriasis and chronic ulcers by comparing their gene expression profiles. The gene expression profiles of psoriatic, wound and chronic ulcer patients, as well as healthy controls, were determined via RNA extraction and next‐generation sequencing of biopsies. In order to identify biomarkers, functional enrichment, differential expression analysis and machine learning algorithms were implemented. It is worth mentioning that the genes IL17A, TNF, KRT16, MMP9, and CD44 exhibited substantial correlations with the pathogenesis of the conditions being studied. As evidenced by their AUC‐ROC values approaching 0.90, machine learning models accurately identified these biomarkers. The differential gene expression was consequently validated via qRT‐PCR, which highlighted the increased expression of matrix remodelling enzymes and inflammatory cytokines. Additionally, genes essential for maintaining epidermis integrity and facilitating wound healing exhibited downregulation. These insights into the molecular mechanisms of psoriasis and chronic ulcers pave the way for the development of targeted therapies, offering hope for improved treatment strategies.
The Ethics of Viewing Illegally Shared Pornography
Authors: Garcia Andrés G. 
Published: November 2023

ABSTRACTI argue that the consumption of illegally shared pornography is often morally problematic. My argument is not based on any general condemnation of pornography or even illegal content sharing as such. Instead, my argument emphasizes that commercial pornography that is illegally shared risks violating the consent and thus the dignity of its performers. In this way, illegally shared pornography is akin to ‘revenge porn’, involving the non‐consensual distribution and consumption of sexually intimate images or videos. The idea is that if viewing sexually explicit content shared without the permission of the people featured within it is unethical, then the same is often true of the consumption of commercial pornographic content that has been shared illegally. My primary focus is on the commercial pornography produced and distributed by the performers themselves, but I also consider the moral status of more traditional forms of pornographic content.
Understanding English‐as‐a‐foreign‐language university teachers' synchronous online teaching satisfaction: A Chinese perspective
Authors: Sun Peijian Paul , Luo Xinran 
Published: November 2023

AbstractBackgroundIn a context where synchronous online teaching has become a new trend of instruction for online education due to the COVID‐19 pandemic, it is valuable and insightful to examine what factors contribute to teachers' satisfaction with synchronous online teaching.ObjectiveInformed by the technology acceptance model (TAM), this study investigated English‐as‐a‐foreign‐language (EFL) university teachers' synchronous online teaching satisfaction in China from social (i.e., subjective norms), institutional (i.e., facilitating conditions), and individual (i.e., self‐efficacy, attitudes toward use, perceived usefulness, and perceived ease of use) levels during the COVID‐19 pandemic.MethodsA total of 250 in‐service EFL university teachers participated in this study. An online questionnaire was adaptively developed to measure teachers' perceptions of and satisfaction with synchronous online teaching. The structural equation modelling (i.e., path analyses) was performed to find out a model that can best represent EFL university teachers' synchronous online teaching satisfaction.Results and ConclusionThe results showed that facilitating conditions, self‐efficacy, attitudes toward use, and perceived usefulness are direct contributors to EFL university teachers' satisfaction with synchronous online teaching. Whereas, perceived ease of use, self‐efficacy, and subjective norms are indirect contributors through the mediation of attitudes toward use. Moreover, different from previous TAM research, facilitating conditions have been found to be the most significant direct factor positively contributing to satisfaction. The findings of this study are expected to shed light on how to enhance teachers' synchronous online teaching satisfaction.
Associations of genetic variations in the M3 receptor with salt sensitivity, longitudinal changes in blood pressure and the incidence of hypertension in Chinese adults
Authors: Zhang Xi , Yao Shi , Bao Peng , Du Mingfei , Hu Guilin , Chu Chao , Wang Dan , Chen Chen , Ma Qiong , Jia Hao , Sun Yue , Yan Yu , Liao Yueyuan , Niu Zejiaxin , Man Ziyue , Wang Lan , Gao Weihua , Li Hao , Zhang Jie , Luo Wenjing , Wang Xin , Wang Yang , Mu Jianjun 
Published: November 2023

AbstractRecent studies have reported the role of the M3 muscarinic acetylcholine receptor (M3R), a member of the G‐protein coupled receptor superfamily, encoded by the CHRM3 gene, in cardiac function and the regulation of blood pressure (BP). The aim of this study was to investigate the associations of CHRM3 genetic variants with salt sensitivity, longitudinal BP changes, and the development of hypertension in a Chinese population. We conducted a chronic dietary salt intervention experiment in a previously established Chinese cohort to analyze salt sensitivity of BP. Additionally, a 14‐year follow‐up was conducted on all participants in the cohort to evaluate the associations of CHRM3 polymorphisms with longitudinal BP changes, as well as the incidence of hypertension. The single nucleotide polymorphism (SNP) rs10802811 within the CHRM3 gene displayed significant associations with low salt‐induced changes in systolic blood pressure (SBP), diastolic blood pressure (DBP), and mean arterial pressure (MAP), while rs373288072, rs114677844, and rs663148 exhibited significant associations with SBP and MAP responses to a high‐salt diet. Furthermore, the SNP rs58359377 was associated with changes in SBP and pulse pressure (PP) over the course of 14 years. Additionally, the 14‐year follow‐up revealed a significant association between the rs619288 polymorphism and an increased risk of hypertension (OR = 1.74, 95% CI: 1.06‐2.87, p = .029). This study provides evidence that CHRM3 may have a role in salt sensitivity, BP progression, and the development of hypertension.
Factors associated with the sexual transmission of Strongyloides stercoralis in men who have sex with men: A systematic review
Authors: Chessell Callum , Rabuszko Lucy , Richardson Daniel , Llewellyn Carrie 
Published: November 2023

AbstractStrongyloides stercoralis is a parasitic worm with a complex life cycle and can cause significant morbidity, including a proctocolitis and life‐threatening hyperinfection syndrome. Limited reports from non‐endemic areas, including in men who have sex with men (MSM), suggest sexual transmission of S. stercoralis. In this systematic review of the published literature, we aimed to explore the associated factors of S. stercoralis in MSM. We systematically searched three bibliographical databases (MEDLINE, CINAHL and EMBASE) up to November 2022. We used a two‐stage process to assess eligibility: the primary author conducted an initial screen of abstracts, and then three authors conducted independent full manuscripts to determine the final eligible manuscripts. We only included manuscripts written in English that contained data on specific factors associated with sexual transmission in MSM. We used the STROBE checklist to assess the risk of bias and synthesized the narrative data using the SWiM method. Seven manuscripts were eligible for this review (four case reports, one case series, one cross‐sectional study and one experimental study), which included 22 individuals from Europe and the Americas. From these studies, S. stercoralis in MSM was associated with living with HIV (including having a low CD4 count and not using antiretrovirals), having a concomitant sexually transmitted infection (Chlamydia trachomatis, Neisseria gonorrhoeae, Treponema pallidum and hepatitis C) and a concomitant (sexually transmitted) protozoal infection (Entamoeba histolytica, Giardia lamblia), travel to the S. stercoralis endemic area, multiple sexual partners from endemic areas, oro–anal sexual contact and chemsex. Although limited by the number of cases in the literature, we have highlighted some possible biological and behavioural risk factors associated with the sexual transmission of S. stercoralis in MSM that could be used to both target future research and S. stercoralis public health control interventions.
Phenotypic and genomic insights into the pathogenicity and antimicrobial resistance of an Enterobacter roggenkampii strain isolated from diseased silver arowana (Osteoglossum bicirrhosum)
Authors: Li Yuerui , Sun Zhongshi 
Published: November 2023

AbstractEnterobacter roggenkampii is an opportunistic pathogen that causes infections in a wide range of hosts. A bacterial strain named EOBSR_19 was isolated from diseased silver arowana, Osteoglossum bicirrhosum. This bacterium was identified as E. roggenkampii based on the phenotypic characteristics and sequence analysis of the16S rDNA and gyrB genes. Average nucleotide identity and phylogenetic analysis based on the whole genome sequence further confirmed the bacterial taxonomy of EOBSR_19. Artificial experimental infection indicated that EOBSR_19 was pathogenic to fish. Antimicrobial susceptibility test showed it was multi‐drug resistant. The EOBSR_19 was found to be resistant to 18 antibiotics belonging to quinolones, macrolides, sulfonamides, aminoglycosides, and β‐lactams classes. The whole genome sequencing analysis showed that EOBSR_19 carried 730 virulence genes that were annotated for different functional modules, such as adhesion and invasion, secretion system, siderophore transport system and bacterial toxin. Among them, the virulence genes related to adhesion and invasion were the most abundant. In addition, drug resistance genes involved in multiple mechanisms of antimicrobial resistance were identified in its genomics, including multidrug resistance efflux pumps, antibiotic inactivating enzymes, and antibiotic binding site mutations. Its genomic analysis via whole‐genome sequencing provided insights into the pathogenicity and antimicrobial resistance.
FODMAP meal challenge test: a novel investigation to predict response to low‐FODMAP diet in non‐constipating irritable bowel syndrome
Authors: Ghoshal Uday C. , Mustafa Uzma , Mukhopadhyay Subhra K. 
Published: November 2023

AbstractBackgroundThough a low‐FODMAP diet improves 50% irritable bowel syndrome (IBS) patients, regional dietary variations, vegetarianism, and long‐term nutritional consequences challenge its implementation. We aimed developing a FODMAP meal challenge test (FMCT). We prospectively studied whether (i) high‐ than low‐FODMAP foods produce more breath H2 among IBS patients than controls; (ii) post‐meal symptoms relate to breath H2; and (iii) novel FMCT predicts response to a low‐FODMAP diet?MethodsForty Rome III IBS and 20 healthy controls underwent an eight‐hour H2 breath test following a low‐ (rice, brinjal, corn, and banana [450 Kcal]) and a high‐FODMAP meal (wheat, kidney bean, pulse, and card [450 Kcal]). Breath H2 (every 15 min) and symptoms following low‐ and high‐FODMAP meals were recorded. IBS‐symptom severity scores were recorded every month for 3‐months on low‐FODMAP diet.ResultsForty Rome III IBS (19 Rome IV positive) were comparable to 20 controls in age and gender. IBS patients (n = 39 excluding one H2 non‐producer) and controls produced more breath H2 after high‐ (greater in IBS) than low‐FODMAP meal. Post‐meal symptoms were commoner in IBS (4/40 [10%] and 27/40 [67.5%] with low‐ and high‐FODMAP, respectively [P < 0.00001]; none in healthy). IBS patients developing post‐high‐FODMAP meal symptoms produced greater H2 (18 PPM [IQR 10.5–23] vs 6 [0–7.2]; P < 0.001). A positive FMCT (breath H2 > 10 PPM above basal with symptoms following high‐FODMAP food) had sensitivity, specificity, and diagnostic accuracy of 78.6%, 66.6%, and 75.6%, respectively, to predict low‐FODMAP diet response.ConclusionsThe novel FMCT predicts response to a low‐FODMAP diet in IBS.
Facilitating endoscopic full‐thickness resection for gastric submucosal tumors with a novel snare traction method (with video)
Authors: Gu Lei , Wang Xiaotong , Ouyang Miao , Li Fujun , Wu Yu , Liu Xiaowei 
Published: November 2023

AbstractBackground and AimEndoscopic full‐thickness resection (EFTR) is a promising technique in treating gastric submucosal tumors originating from the muscularis propria (SMT‐MPs). However, it is challenging without counter‐traction.MethodsA snare was inserted through the forceps channel to grasp the part of the tumor or the mucosa connected to the tumor. The outer sheath and inner wire of snare in vitro were fixed by a pair of hemostatic forceps. The handle of snare was cut off, and the endoscope was pulled out without affecting the traction state of snare. Snare‐assisted EFTR (EFTR‐S) was then performed with counter‐traction. One hundred and four patients with gastric SMT‐MPs who received the procedure of EFTR with or without snare traction method were retrospectively analyzed using univariate and multiple regressions, and covariates were adjusted in the multiple analysis.ResultsCompared with EFTR group (n = 36), EFTR‐S group (n = 68) showed a higher operative success rate (95.6% vs 72.2%, P = 0.001), a lower incidence of intraoperative hemorrhage (4.4% vs 16.7%, P = 0.038) and shorter operative time among operative successes (53.6 ± 16.6 min vs 67.7 ± 33.4 min, P < 0.001). Univariate logistic analysis showed that snare traction represented a significant factor, which could improve operative successful rate (odds ratio, 8.3; 95% confidence interval, 2.1 to 32.7; P = 0.002). Postoperative outcomes and adverse events among operative successes were similar between the two groups.ConclusionsThis novel snare traction method may provide an effective counter‐traction and reduce the difficulty of EFTR for gastric SMT‐MPs.
Elusive coral and fish: Reconsidering the shore‐offshore separation in Caribbean archipelagos
Authors: Rivera‐Sotelo Aída‐Sofía 
Published: November 2023

AbstractTo deathly stories of marine biodiversity loss, this article adds stories of deep connectivity and multispecies migrations that cut across the simultaneous promotion of coral restoration nearshore and gas exploration offshore in Colombian governmental strategies to meet international commitments in the United Nations Convention on Climate Change. My argument is that these historically and spatially situated relations in the Caribbean of Colombia are elusive—hard to grasp and predict—when using only the lens of extinction. The limits of coral restoration experiments and artisanal fishing far out in the sea indicate vital spaces of transit that transgress shore/nearshore/offshore separations. In this sense, these vital spaces of transit are elusive to the governmental strategies meant to protect coral and fish. This analysis offers a geography of disappearance to extinction studies, an approach to separations within the sea in times of climate change, and attention to a region overlooked in social research.
Engendering “Illegality”: Blackness, citizenship, and Dominico‐Haitian motherhood
Authors: Lyon Jacqueline 
Published: November 2023

AbstractIn 2013,the Dominican Republic's highest court ruled to retroactively apply the elimination of jus soli citizenship, commonly known as birthright citizenship. The ruling impacted more than 200,000 Dominicans of Haitian descent and culminated a decades‐long attack on territorially based citizenship in the country, which largely provided access to the children of Haitians, who make up more than 80% of the country's migrants. The intensification of anti‐birthright citizenship politics and the implementation of a host of restrictive measures since 2004 shifted focus from the male labor as the primary target of migrant control, to the “pregnant migrant.” This article examines how these policies shaped Dominico‐Haitian women's experiences of motherhood by drawing on interviews and participant observation undertaken from 2014 to 2018 in and around Santo Domingo. I argue that anti‐birthright citizenship politics target Black women's reproduction in a form of racialized violence that shares continuities with the nation's history of enslavement.
Fat transplant: Amazing growth and regeneration of cells and rebirth with the miracle of fat cells
Authors: Hajimortezayi Zahra , Daei Narges , Gholizadeh Nasim , Zakeri Mana , Alhili Farah , Hasanzadeh Sajedeh , Hormozi Arezoo , Ebrahimi Faezeh , Zamani Majid 
Published: November 2023

AbstractBackgrounds and ObjectiveDuring fat transplantation, adipose tissue is removed from the body and injected into different areas under the skin. The goal of this review article is to look into the efficacy and applicability of fat transplantation in regenerative medicine and rejuvenation, including Nanofat, Microfat, and Millifat.MethodsAs a search strategy and study selection, we searched the PubMed and Medline databases until 2023 using related keywords (e.g., Nanofat, Microfat and Millifat, Regenerative Medicine, and Rejuvenation).ResultsAutologous fat transplantation has no risk of an allergic reaction or rejection of the transplant by the individual. Autologous adipose tissue is considered an ideal filler for facial rejuvenation and is suggested as the most biocompatible and non‐immunogenic skin filler. Adipose tissue transplant may have semi‐permanent to permanent effects. According to recent reports, adipose tissues possess a high percentage of mature stem cells. The effect of regenerating adipose tissue and its intrinsic cells can be described as an obvious process. Variations in the sizes of adipose tissues can result in different results depending on the surgical site. Based on topographic assessment, graft fats are assigned depending on the anatomical locations and the size such as Millifat (2–2.5 mm), Microfat (1 mm), and Nanofat (500 μm or less).ConclusionSome characteristics of fat tissue increase its effectiveness, such as increasing stem cells, growth factors, cytokines, and compounds effective in repair, regeneration, and rejuvenation.
Clinical presentation, course, and prognosis of patients with mixed connective tissue disease: A multicenter retrospective cohort
Authors: Chevalier Kevin , Thoreau Benjamin , Michel Marc , Godeau Bertrand , Agard Christian , Papo Thomas , Sacre Karim , Seror Raphaèle , Mariette Xavier , Cacoub Patrice , Benhamou Ygal , Levesque Hervé , Goujard Cécile , Lambotte Olivier , Bonnotte Bernard , Samson Maxime , Ackermann Félix , Schmidt Jean , Duhaut Pierre , Kahn Jean‐Emmanuel , Hanslik Thomas , Costedoat‐Chalumeau Nathalie , Terrier Benjamin , Regent Alexis , Dunogue Bertrand , Cohen Pascal , Guern Véronique Le , Hachulla Eric , Chaigne Benjamin , Mouthon Luc 
Published: November 2023

AbstractObjectivesThe objective of this study is to better characterize the features and outcomes of a large population of patients with mixed connective tissue disease (MCTD).MethodsWe performed an observational retrospective multicenter cohort study in France. Patients who fulfilled at least one diagnostic criterion set for MCTD and none of the criteria for other differentiated CTD (dCTD) were included.ResultsThree hundred and thirty patients (88% females, median [interquartile range] age of 35 years [26–45]) were included. The diagnostic criteria of Sharp or Kasukawa were met by 97.3% and 93.3% of patients, respectively. None met other classification criteria without fulfilling Sharp or Kasukawa criteria. After a median follow‐up of 8 (3–14) years, 149 (45.2%) patients achieved remission, 92 (27.9%) had interstitial lung disease, 25 (7.6%) had pulmonary hypertension, and 18 (5.6%) died. Eighty‐five (25.8%) patients progressed to a dCTD, mainly systemic sclerosis (15.8%) or systemic lupus erythematosus (10.6%). Median duration between diagnosis and progression to a dCTD was 5 (2–11) years. The presence at MCTD diagnosis of an abnormal pattern on nailfold capillaroscopy (odds ratio [OR] = 2.44, 95% confidence interval [95%CI] [1.11–5.58]) and parotid swelling (OR = 3.86, 95%CI [1.31–11.4]) were statistically associated with progression to a dCTD. Patients who did not progress to a dCTD were more likely to achieve remission at the last follow‐up (51.8% vs. 25.9%).ConclusionsThis study shows that MCTD is a distinct entity that can be classified using either Kasukawa or Sharp criteria, and that only 25.8% of patients progress to a dCTD during follow‐up.
Comparison of low‐level laser therapy and standard treatment for temporomandibular disorders: An assessment of therapeutic and placebo effects
Authors: Chamani Goli , Zarei Mohammad Reza , Rad Maryam , Mafi Sahar 
Published: November 2023

AbstractBackgroundDespite extensive research on the use of low‐power lasers for TMD treatment, the extent of their effectiveness remains uncertain.ObjectiveThis study aimed to investigate the therapeutic or placebo effect of LLLT for TMD, and to compare it with standard treatment methods. A unique aspect of this study was the inclusion of a control group that received only standard treatment, allowing for an assessment of the placebo effect of LLLT.MethodsA total of 42 patients with TMD were referred to Kerman Dental School Pain Clinic and were randomly assigned to three groups: group A received LLLT, group B was a placebo group and group C was a control group that received only standard treatment. The laser groups received gallium‐aluminium‐arsenide laser treatment twice a week for 10 sessions. Patients' jaw movement rate indicators and VAS index were evaluated at the start of treatment, and indicators were re‐recorded every week for 5 weeks. SPSS 21 was used for statistical analysis, including ANOVA and Tukey's post hoc tests for inter‐group comparisons. The repeated measurement test was used to analyse the data.ResultsAll groups showed significant improvement in VAS indicators (p = .0001), lateral jaw movements (p = .0001), forward jaw movement (p = .007) but not for maximum mouth opening. No significant difference was observed between the groups at the end of the study (p = .000).ConclusionOur study provides insights into LLLT's effectiveness for TMD, suggesting it cannot replace standard treatment alone. These findings contribute to the literature and emphasise the importance of including a control group in future studies to assess the placebo effect of LLLT.