bluuebunny/crossref_metadata_2025_split huggingface dataset:
Chondrosarcoma secondary to hereditary multiple osteochondromas with spinal cord compression: A case report and systematic review
Authors: Silva José Elmano , Monteiro Gabriel de Almeida , Silva Stefanie Torres e , Bezerra Gabriel Marinheiro dos Santos , Cavalcante-Neto Joaquim Francisco , Bezerra Diego de Aragão , Vasconcelos Janssen Loiola Melo , Leal Paulo Roberto Lacerda 
Published: November 2023

Background:
Hereditary multiple osteochondromas (HMOs) are a rare genetic disorder characterized by the formation of multiple benign osteochondromas that can undergo malignant transformation into chondrosarcoma.

Case Description:
A 24-year-old male with a history of HMO and osteochondroma surgery 4 years ago, presented with back pain and paresthesias. The magnetic resonance showed a right paravertebral infiltrating mass at the T12–L1 level causing spinal cord compression. Following en bloc resection of the tumor, the patient’s symptoms/ signs resolved. The final pathological diagnosis was consistent with a chondrosarcoma.

Conclusion:
Chondrosarcomas secondary to HMO with spinal cord compression are rare. These patients often presenting with significant myelopathy/cord compression should undergo gross total resection where feasible to achieve the best outcomes.
PEOPLE AND POWER IN “BORIS GODUNOV” BY A.S. PUSHKIN AND “DIMITRY THE IMPOSTOR” BY F. V. BULGARIN
Authors: Подгорная Е.Г. 
Published: November 2023

В статье рассматривается тема борьбы народа и власти в драме А. С. Пушкина «Борис Годунов» и романе Ф. В. Булгарина «Димитрий Самозванец». В основе обоих произведений лежит идея о том, что преступление монарха неизменно влечет за собой народные несчастья и волнения, но способы развития этой идеи значительно отличаются.
The article considers the theme of the struggle between the people and the power in A. S. Pushkin’s drama “Boris Godunov” and F. V. Bulgarin’s novel “Dimitry the Impostor”. Both works are based on the idea that the monarch’s crime invariably entails people’s misfortunes and unrest, but the ways of developing the idea differ significantly.
Application of deep oscillation therapy in the treatment of peripheral arterial diseases
Authors: Trybulski R. , Biolik G. , Kuczmik W. , Ivasyk N. , Tyravska O. 
Published: November 2023

Intermittent claudication is a common symptom of peripheral arterial disease, affecting up to 50% of patients over the age of 50, which is characterized by pain, discomfort, and cramping in the leg muscles during physical activity. Intermittent claudication is a common symptom of lower extremity arterial disease (LEAD), which significantly impacts patients’ quality of life and drives healthcare costs. Current treatments for intermittent claudication are often inadequate, leading to a need for more effective treatments. Developing new treatments is critical to improve outcomes for patients and address the public health implications of LEAD. This study’s aim was to present the impact of comprehensive physiotherapy, conducted independently, with the supervision of a physiotherapist, for 14 weeks, on a patient with intermittent claudication caused by peripheral arterial disease. The therapy included bicycle training in a form of physical therapy at home, combined with deep oscillation therapy. Deep oscillation therapy involved the use of an electrostatic field with a frequency of 5 to 250 Hz. The field was applied following the lymphatic drainage methodology. In the discussed case, a statistically significant and favourable increase in the measured variables was observed, such as the increase of bone-brachial index from 0.65 to 0.8, the increase of tissue perfusion, measured by laser Doppler flowmetry, from 12.3% to 61%, depending on the measurement site, and the increase in pain-free walking distance by 451%. TcPO2 measurement in the affected leg increased from 31 to 48 mmHg. The use of physical therapy at home combined with deep oscillation showed improvements in pain-free walking distance, Ankle Brachial Index, and other measures in patients with peripheral arterial disease. Deep oscillation therapy demonstrated potential analgesic effects but also raised concerns about possible nerve damage. The study indicated that physical therapy at home might serve as an alternative to supervised exercise therapy, but it had limitations like a small sample size and lack of direct comparisons.
Effect of noninvasive respiratory support on interstitial lung disease with acute respiratory failure: A systematic review and meta-analysis
Authors: Sanguanwong Natthawan , Jantarangsi Nattawat , Ngeyvijit Jinjuta , Owattanapanich Natthida , Phoophiboon Vorakamol 
Published: November 2023

Background Primary studies have demonstrated the effectiveness of noninvasive respiratory supports, including noninvasive positive pressure ventilation (NIPPV) and high flow nasal cannula (HFNC), for improving oxygenation and ventilation in patients with interstitial lung diseases (ILDs) and acute respiratory failure (ARF). These studies have not been synthesized and are not included in current practice guidelines. This systematic review with meta-analysis synthesizes studies that compared the effectiveness of NIPPV, HFNC and conventional oxygen therapy (COT) for improving oxygenation and ventilation in ILD patients with ARF. Methods MEDLINE, EMBASE and the Cochrane Library searches were conducted from inception to August 2023. An additional search of relevant primary literature and review articles was also performed. A random effects model was used to estimate the PF ratio (ratio of arterial oxygen partial pressure to fractional inspired oxygen), PaCO2 (partial pressure of carbon dioxide), mortality, intubation rate and hospital length of stay. Results Ten studies were included in the systematic review and meta-analysis. Noninvasive respiratory supports demonstrated a significant improvement in PF ratio compared to conventional oxygen therapy (COT); the mean difference was 55.92 (95% CI [18.85-92.99]; p=0.003). Compared to HFNC, there was a significant increase in PF ratio in NIPPV (mean difference 0.45; 95% CI [0.12–0.79]; p=0.008). There were no mortality and intubation rate benefits when comparing NIPPV and HFNC; the mean difference was 1.1; 95% CI [0.83-1.44]; p=0.51 and 1.86; 95% CI [0.42-8.33]; p=0.42, respectively. In addition, there was a significant decrease in hospital length of stay in HFNC compared to NIPPV (mean difference 9.27; 95% Cl [1.45 – 17.1]; p=0.02). Conclusions Noninvasive respiratory supports might be an alternative modality in ILDs with ARF. NIPPV demonstrated a potential to improve the PF ratio compared to HFNC. There was no evidence to support the benefit of NIPPV or HFNC in terms of mortality and intubation rate.
Effectiveness and safety of drugs for the treatment of gastroparesis: evidence-based medicine data. Review
Authors: Tkach S. M. 
Published: November 2023

Gastroparesis is a motility disorder of the upper gastrointestinal tract, characterized by delayed emptying of the stomach from solid substances, in the absence of any mechanical signs of obstruction of the stomach or duodenum. The etiology of gastroparesis is heterogeneous, but there are three well‑known subtypes: diabetic, iatrogenic, resulting from upper gastrointestinal surgery or medication, and idiopathic gastroparesis. Despite recently updated guidelines for the management of patients with gastroparesis, this condition remains difficult to diagnose and treat. A recent systematic review and network meta‑analysis of randomized controlled trials (RCTs) evaluated the efficacy and safety of all drugs tested in patients with gastroparesis. The only FDA‑approved drug is metoclopramide, a dopamine D2 antagonist and weak 5‑HT4 agonist, which in gastroparesis is approved for a maximum of three months of treatment due to endocrine, cardiac, and neurologic side effects. The results of the conducted meta‑analysis confirmed the effectiveness of dopamine antagonists in gastroparesis. Domperidone has been the subject of a warning due to an increased risk of QT prolongation on the electrocardiogram, but pharmacoepidemiological data suggest that this is rare, and ventricular arrhythmia occurs only in 0.02% of patients treated with the drug. A meta‑analysis suggested that clebopride, another dopamine antagonist, is an effective drug for gastroparesis, ranking first among effects on global symptoms, although this was shown in only one RCT, and the drug is not yet available in many countries, including the USA. The tachykinin‑1 antagonists aprepitant and tradipitant ranked third and fifth, respectively, for effects on global symptoms of gastroparesis, but when examined for effects on global symptoms according to drug class, they ranked second. Although 5‑HT4 agonists have not been shown to be sufficiently effective, trials of velosetrag are ongoing, and prucalopride was superior to placebo in a one cross‑over study included in the meta‑analysis.
Domestic researchers who have made important contributions to the study of digestive system diseases: images in art. Georgiy Yosypovych Burchynsky
Authors: Gubergrits N. B. , Byelyayeva N. V. , Linevska K. Y. , Suprun O. O. , Tsys O. V. 
Published: November 2023

Georgiy Yosypovych Burchynsky (1908 — 1993) — Doctor of Medical Sciences, Professor, Honored Scientist of Ukraine, and laureate of the State Prize of Ukraine. G. Y. Burchynsky, throughout his life, was brought up on the traditions of the Kyiv therapeutic school. A close relationship with the Kyiv therapeutic school largely determined his personality as a doctor, teacher, scientist, and head of the department. In the years 1954 — 1962, Georgiy Yosypovych was the head of the Department of Therapy at the School of Dentistry. Since 1962, he had been the head of the Department of Faculty Therapy at the Kyiv Medical Institute for 24 years. G. Y. Burchynsky paid much attention to the study of pulmonary pathology. Based on the research materials, the monograph «Suppurative processes in the lungs» was issued in 1950. In particular, G. Y. Burchynsky developed a pathogenetic classification of pulmonary suppurations. One of the first in Ukraine, he applied the technique of endobronchial administration of antibiotics, He developed and introduced into practice the technique of zonal, or local, instillation using a bronchoscope. Gastrointestinal diseases have always been in the focus of Kyiv therapeutic school. G. Y. Burchynsky paid special attention attention to the problems of peptic ulcers. As a result, new data were obtained about this disease, which is outwardly clear but inwardly mysterious. G. Y. Burchynsky and his colleagues did a detailed study on the course of peptic ulcers, even during wartime. They looked at the etiology, pathogenesis, changes in the ultrastructure of the gastric mucosa, general changes, and questions about pathogenetic therapy for this disease. Experimental studies on the model of reproduction of a hypothalamic ulcer, as well as the results of studying the ultrastructure of gastroduodenal mucosa, confirmed the importance of the disturbances of nervous trophism. An experimental study on the pharmacodynamics of anticholinergics, which suppress cholinergic stimulation of the stomach and duodenum, showed that they can be used in clinical practice as a way to treat peptic ulcer disease. Under the supervision of G. Y. Burchynsky, two doctoral dissertations on the problem of peptic ulcers were defended at the department. Observations and results of the studies, performed by Georgiy Yosypovych and his colleagues, are reflected in the papers and monographs, such as “Peptic Ulcer,” “Clinical Gastroenterology,” and the relevant chapters of multi­volume guidelines and the Big Medical Encyclopedia.
5-year adherence to adjuvant endocrine treatment in Dutch women with early stage breast cancer: A population-based database study (2006–2016)
Authors: van den Biggelaar Yannick J.P.G. , Kuiper Josephina G. , van der Sangen Maurice J.C. , Luiten Ernest J.T. , Siesling Sabine , van Herk-Sukel Myrthe , Voogd Adri C. , Mesters Ilse 
Published: November 2023

BACKGROUND: Hormonal receptor (HR) positive breast tumors are common. Adjuvant hormonal therapy (AHT) with tamoxifen or Aromatase Inhibitors (AIs) is beneficial depending on the stage of the tumor. Despite the fact that AHT has been shown to improve survival and recurrence, Dutch adherence rates, which were mostly dependent on Tamoxifen prescriptions until 2006, plummeted from 80% after one year to 50% after five years. Nonadherence with AHT reduces its effectiveness. This research presents more recent adherence statistics (from 2006 to 2016), on a larger sample (7,996 vs 1,451), as well as factors that influence AHT adherence. In addition to tamoxifen data, AIs are now included. OBJECTIVE: As low use of adjuvant endocrine therapy is a potentially important and modifiable risk factor for poor outcome, it is important to monitor the rate as an indicator of women’s burden of disease and the direction of adherence trends. METHODS: The Netherlands Cancer Registry (NCR) was used to find women with early-stage breast cancer who started AHT within a year of surgery and were linked to the PHARMO Database Network (n = 8,679). The Kaplan-Meier approach was used to measure AHT adherence five years after treatment was started, with a 60-day gap between refills as our primary outcome. Furthermore, the Medication Possession Rate (MPR) was determined using a cutoff of ≥80%. Analysis was performed on influential factors of adherence. RESULTS: The proportion of persistent women declined over time to reach 46.6% at the end of the fifth year and 53.3% of the women had a MPR ≥80% during the fifth year. Older and being diagnosed in 2006-2010 were associated with AHT adherence. CONCLUSION: Dutch 5-year AHT adherence appears to remain poor. Improving AHT adherence in HR+ breast cancer survivors is a critical medical need.
Analysis of Costs for Imaging-Assisted Pharmaceutical Intervention in Alzheimer’s Disease with Lecanemab: Snapshot of the First 3 Years
Authors: Perron Jarrad , Scramstad Carly , Ko Ji Hyun 
Published: November 2023

Background: The approval of lecanemab for the treatment of Alzheimer’s disease (AD) by the Food and Drug Administration in the United States has sparked controversy over issues of safety, cost, and efficacy. Furthermore, the prognostication of cognitive decline is prohibitively difficult with current methods. The inability to forecast incipient dementia in patients with biological AD suggests a prophylactic scenario wherein all patients with cognitive decline are prescribed anti-AD drugs at the earliest manifestations of dementia; however, most patients with mild cognitive impairment (approximately 77.7%) do not develop dementia over a 3-year period. Prophylactic response therefore constitutes unethical, costly, and unnecessary treatment for these patients. Objective: We present a snapshot of the costs associated with the first 3 years of mass availability of anti-AD drugs in a variety of scenarios. Methods: We consider multiple prognostication scenarios with varying sensitivities and specificities based on neuroimaging studies in patients with mild cognitive impairment to determine approximate costs for the large-scale use of lecanemab. Results: The combination of fluorodeoxyglucose and magnetic resonance was determined to be the most cost-efficient at $177,000 for every positive outcome every 3 years under an assumed adjustment in the price of lecanemab to $9,275 per year. Conclusions: Imaging-assisted identification of cognitive status in patients with prodromal AD is demonstrated to reduce costs and prevent instances of unnecessary treatment in all cases considered. This highlights the potential of this technology for the ethical prescription of anti-AD medications under a paradigm of imaging-assisted early detection for pharmaceutical intervention in the treatment of AD.
Association of Age-Related Spontaneous Internal Jugular Vein Reflux with Cognitive Impairment and Incident Dementia
Authors: Adachi Utako , Toi Sono , Hosoya Megumi , Hoshino Takao , Seki Misa , Yoshizawa Hiroshi , Tsutsumi Yukiko , Maruyama Kenji , Kitagawa Kazuo 
Published: November 2023

Background: It remains unclear whether changes in the venous circulation contribute to cognitive decline. Objective: This study aimed to clarify whether the spontaneous jugular vein reflux (JVR) is associated with cognitive impairment and incident dementia. Methods: Patients with any evidence of cerebral vessel disease on magnetic resonance imaging (MRI) were consecutively enrolled between October 2015 to July 2019. We employed carotid duplex sonography to measure the internal jugular vein (IJV). The subjects were classified into two groups based on the degree of JVR on either side: none, mild (JVR(–) group) and moderate, severe (JVR (+) group) JVR. They underwent both the Mini-Mental State Examination (MMSE) and Montreal Cognitive Assessment-Japanese (MoCA-J) global tests. Their cognitive status was prospectively assessed until March 2023. Results: 302 patients with an MMSE score ≥24 underwent duplex sonography of the IJV. Among them, 91 had spontaneous JVR on either side. Both MMSE and MoCA-J were significantly lower in patients with JVR (+) group than in the JVR (–) group. After the adjustment for risk factors and MRI findings, intergroup differences in MoCA-J remained significant. Among the cognitive subdomains, median executive function and memory scores were significantly lower in the JVR (+) group than in the JVR (–) group. During the median 5.2-year follow-up, 11 patients with incident dementia were diagnosed. Patients with severe JVR were significantly more likely to be diagnosed with dementia (log-rank test, p = 0.031). Conclusions: Spontaneous IJV reflux especially severe JVR, was associated with global cognitive function, and potentially with incident dementia.
Ondes Martenot at the World Exhibition in Paris in 1937
Authors: Holubov Dmytro 
Published: November 2023

The purpose of the study is to reveal the figurative, semantic and symbolic specificity of the interpretation of the timbre of "Ondes Martenot" in line with the musical, cultural, and socio-political guidelines of the World Exhibition in Paris in 1937. Research methodology. Cultural-historical, interdisciplinary historical-cultural, as well as analytical-musicological methods were essential for this work. The scientific novelty of the work lies in the fact that it introduces for the first time into the circulation of art historians the materials related to the musical component of the artistic events of the Paris World Exhibition of 1937, voiced, including with the help of the timbralness of the "Ondes Martenot", which became the personification of the union of art and technology as a leading symbol of its shares. Conclusions. Interwar France, being at the edge of a difficult socio-political and cultural situation, grasped at the saving idea for it – the holding of another "World's Fair" in 1937, the slogan of which was chosen as the thesis – "Art and technology in modern life". Achieving the set goals and demonstrating to the whole world the high-tech side of France's existence became possible thanks to the musical part of the exhibition, namely "concert-performances" and night shows on the banks of the Seine – "Holidays of sound, water and light". An important component of most of these presentations is the electronic musical instrument "Ondes Martenot". As a result, the popularity of "concert-performances" and night extravaganzas "Saint of Light", the essential component of which were the spiritual and mysterious timbral features of the "Ondes Martenot", stimulated the aesthetic preferences of modernist composers. It was during this period that a significant part of the musical repertoire was created for this instrument, which was always connected precisely with the sphere of the Sacred and the Cosmic. This also marked the leading spiritual, social, and aesthetic guidelines of the World Exhibition of 1937, which, in the most difficult political situation on the eve of the Second World War, tried, including through the diverse involvement of the timbrality of the "Ondes Martenot" involved in the mysterious spectacular actions of this project, unite the human community and avoid global catastrophe.
Keywords: World Exhibition in Paris in 1937, "Feasts of sound, water and light", "concerts-spectacles", Ondes Martenot.
Childhood obesity in urban Ghana: evidence from a cross-sectional survey of in-school children aged 5-16 years
Authors: Ganle John Kuumuori , Boakye Priscilla , Baatiema Leonard 
Published: November 2023

<p><strong>Background</strong></p>
<p>Childhood obesity is a growing public health concern in many low-income urban settings; but its determinants are not clear. The purpose of this study is to assess the prevalence of childhood obesity and associated factors among in-school children aged 5–16 years in a Metropolitan district of Ghana.</p>
<p><strong>Methods</strong></p>
<p>A cross-sectional quantitative survey was conducted among a sample of 285 in-school children aged 5–16 years. Pre-tested questionnaires and anthropometric data collection methods were used to collect data. Descriptive, bivariate, binary and multivariate logistic regression statistical techniques were used to analyse data.</p>
<p><strong>Results</strong></p>
<p>Some 46.9% (42.2% for males and 51.7% for females) of the children were overweight. Of this, 21.2% were obese (BMI falls above 95th percentile). Childhood obesity was higher in private school (26.8%) than public school (21.4%), and among girls (27.2%) than boys (19%). Factors that increased obesity risks included being aged 11–16 as against 5–10 years (aOR = 6.07; 95%CI = 1.17–31.45; <em>p</em> = 0.025), having a father whose highest education is ‘secondary’ (aOR =2.97; 95% CI = 1.09–8.08; <em>p</em> = 0.032), or ‘tertiary’ (aOR = 3.46; 95% CI = 1.27–9.42; <em>p</em> = 0.015), and consumption of fizzy drinks most days of the week (aOR = 2.84; 95% CI = 1.24–6.52; <em>p</em> = 0.014). Factors that lowered obesity risks included engaging in sport at least 3times per week (aOR = 0.56; 95% CI = 0.33–0.96; <em>p</em> = 0.034), and sleeping for more than 8 h per day (aOR = 0.38; 95% CI = 0.19–0.79; <em>p</em> = 0.009).</p>
<p><strong>Conclusion</strong></p>
<p>Higher parental (father) educational attainment and frequent consumption of fizzy drinks per week may increase obesity risks among in-school children aged 5–16 years in the Metropolitan district of Ghana. However, regular exercise (playing sport at least 3 times per week) and having 8 or more hours of sleep per day could lower obesity risks in the same population. Age and sex-appropriate community and school-based interventions are needed to promote healthy diet selection and consumption, physical activity and healthy life styles among in-school children.</p>