bluuebunny/crossref_metadata_2025_split huggingface dataset:
Application of joint commission international standard combined with 6S management mode in the management of emergency medical equipment
Authors: He Jing , Cang Yanhong , Wei Chunhong , Wang Hui , Xu Yan , Han Yan 
Published: February 2024

AbstractObjectiveThe medical instruments used in the emergency department have a wide coverage and prominent importance. The study was aimed to observe the effect of joint commission international (JCI) standard combined with 6S management mode in emergency medical equipment.MethodsMedical equipment and nursing staff in the emergency department of our hospital were the subjects of the research. We compared the management status (standard placement, good cleaning, good maintenance, complete records) of medical equipment after the application of JCI standard combined with 6S management mode was compared with that before the application. Working time associated with medical equipment, equipment repair ratio, nurses' satisfaction with medical equipment use and management were also compared.ResultsAfter the application of JCI standard combined with 6S management mode, the proportion of instances meeting standards for placement, cleaning, maintenance, and record‐keeping was higher than before the application (p < 0.05), the time of instrument acquisition was significantly lower than before the application (p < 0.001), the proportion of instrument repair was lower than before application (p < 0.05), and the proportion of nurses satisfied with the use and management of the instrument was higher than before (p < 0.05). There was no statistical difference in instrument cleaning time, instrument maintenance time and environmental management time after the application of JCI standard combined with 6S management mode compared with before application (p > 0.05).ConclusionJCI standard combined with 6S management mode can standardize the use of emergency medical instruments, reduce the risk of instrument damage, increase work efficiency, improve nurses' satisfaction with medical instrument management, and are therefore worthy of clinical application.
How receptor tyrosine kinase‐like orphan receptor 1 meets its partners in chronic lymphocytic leukemia
Authors: Mouawad Nayla , Ruggeri Edoardo , Capasso Guido , Martinello Leonardo , Visentin Andrea , Frezzato Federica , Trentin Livio 
Published: February 2024

AbstractChronic lymphocytic leukemia (CLL) is the most common leukemia in western societies, recognized by clinical and molecular heterogeneity. Despite the success of targeted therapies, acquired resistance remains a challenge for relapsed and refractory CLL, as a consequence of mutations in the target or the upregulation of other survival pathways leading to the progression of the disease. Research on proteins that can trigger such pathways may define novel therapies for a successful outcome in CLL such as the receptor tyrosine kinase‐like orphan receptor 1 (ROR1). ROR1 is a signaling receptor for Wnt5a, with an important role during embryogenesis. The aberrant expression on CLL cells and several types of tumors, is involved in cell proliferation, survival, migration as well as drug resistance. Antibody‐based immunotherapies and small‐molecule compounds emerged to target ROR1 in preclinical and clinical studies. Efforts have been made to identify new prognostic markers having predictive value to refine and increase the detection and management of CLL. ROR1 can be considered as an attractive target for CLL diagnosis, prognosis, and treatment. It can be clinically effective alone and/or in combination with current approved agents. In this review, we summarize the scientific achievements in targeting ROR1 for CLL diagnosis, prognosis, and treatment.
From humanitarian crisis to employment crisis: The lives and livelihoods of South Sudanese refugee health workers in Uganda
Authors: Palmer Jennifer , Sokiri Stephen , Char Jacob Nhial Bol , Vivian Amuna , Ferris Denise , Venner Georgia , Dak John Jal 
Published: February 2024

AbstractDespite the many benefits of refugee health workers for health systems, they commonly face challenges integrating into host country workforces. The Global Code of Practice on International Recruitment of Health Personnel, which should monitor and protect migrant health workers, offers little guidance for refugees and research is needed to inform strategy. Based on interviews with 34 refugee health workers and 10 leaders across two settlements supporting populations fleeing the humanitarian crisis in South Sudan since 2013, we describe the governance and social dynamics affecting South Sudanese refugee health worker employment in Uganda. Refugees in Uganda legally have the right to work but face an employment crisis. Refugee health workers report that systemic discrimination, competition from underemployed domestic workers, unclear work permit rules and expensive credentialling processes exclude them from meaningful work in public health facilities and good jobs in the humanitarian response. This pushes them into unchallenging roles in private clinics, poorly remunerated positions on village health teams or out of the health sector altogether. Health system strengthening initiatives in Uganda to integrate humanitarian and government services and to deter the domestic workforce from emigration have overlooked the potential contributions of refugee health workers and the employment crisis they face. More effort is needed to increase fairness in public sector recruitment practices for refugee health workers, support credentialling, training opportunities for professional and non‐professional cadres, job placements, and to draw attention to the public benefits of refugee health worker employment alongside higher spending on human resources for health.
An introduction to Criteria for Reporting and Evaluating Exposure Datasets (CREED) for use in environmental assessments
Authors: Merrington Graham , Nowell Lisa H. , Peck Charles 
Published: February 2024

Abstract
Risks posed by environmental exposure to chemicals are routinely assessed to inform activities ranging from environmental status reporting to authorization and registration of chemicals for commercial uses. Environmental risk assessment generally relies on two key values generated from exposure data and ecotoxicity data. Data sets of measured concentrations of chemicals in environmental matrices, referred to here as exposure data, are widely used to support environmental risk management, decision-making, and reporting, such as for chemical screening, ecological or human health risk assessments, and establishment of guidelines. Practitioners have developed schemes to determine the suitability of ecotoxicity data for specific purposes, focused on evaluating reliability and relevance, but analogous schemes are not available for exposure data. Moreover, regulatory guidance arguably provides less resolution on reporting and evaluating exposure data sets compared to ecotoxicity data. The evaluation of exposure data sets is subject to limitations from variable or unreported data quality objectives and/or from differences in expert judgments, potentially introducing bias and leading to decisions based on flawed and/or inconsistent information. Exposure data sets should be evaluated for reliability and relevance prior to use in environmental assessments. This paper is the first of a four-paper series detailing the outcomes of a Society of Environmental Toxicology and Chemistry technical workshop that has developed Criteria for Reporting and Evaluating Exposure Datasets (CREED). The workshop participants developed practical, systematic criteria for consistent and transparent evaluation of the reliability (quality) and relevance (fitness for purpose) of exposure data. This guidance should apply to many different (unspecified) purposes of assessment. CREED can be used to evaluate existing data sets, but can also inform data generators interested in improving their data collection and reporting to maximize data utility to other users. This first paper details existing frameworks for the evaluation of exposure data sets and demonstrates the need for CREED, drawing from different regulatory assessments, and describes the technical workshop. Integr Environ Assess Manag 2024;20:975–980. © 2024 SETAC
Key Points
Frameworks for the evaluation reliability (quality) and relevance (fitness for purpose) of exposure data are not as well developed as frameworks for evaluating reliability and relevance. Not all exposure data are fit for all purposes, including secondary applications beyond the original intent. CREED provide a consistent, transparent, and practical approach for ensuring exposure data quality and fitness for purpose. CREED serve as guidance for data users, data generators, and database owners.
Effects of water quality on palladium-induced olfactory toxicity and bioaccumulation in rainbow trout (Oncorhynchus mykiss)
Authors: Simonis Carolyn , Zink Lauren , Johnston Sarah E. , Bogard Matthew , Pyle Gregory G. 
Published: February 2024

Abstract
Through emission processes, palladium (Pd) particulates from industrial sources are introduced into a range of ecosystems including freshwater environments. Despite this, research on Pd-induced bioaccumulation, uptake, and toxicity is limited for freshwater fishes. Unlike other metals, there are currently no regulations or protective guidelines to limit Pd release into aquatic systems, indicating a global absence of measures addressing its environmental impact. To assess the olfactory toxicity potential of Pd, the present study aimed to explore Pd accumulation in olfactory tissues, olfactory disruption, and oxidative stress in rainbow trout (Oncorhynchus mykiss) following waterborne Pd exposure. Olfactory sensitivity, measured by electro-olfactography, demonstrated that Pd inhibits multiple pathways of the olfactory system following 96 h of Pd exposure. In this study, the concentrations of Pd for inhibition of olfactory function by 20% (2.5 μg/L; IC20) and 50% (19 μg/L; IC50) were established. Rainbow trout were then exposed to IC20 and IC50 Pd concentrations in combination with varying exposure conditions, as changes in water quality alter the toxicity of metals. Independent to Pd, increased water hardness resulted in decreased olfactory perception owing to ion competition at the olfactory epithelium. No other environmental parameter in this study significantly influenced Pd-induced olfactory toxicity. Membrane-associated Pd was measured at the olfactory rosette and gill following exposure; however, this accumulation did not translate to oxidative stress as measured by the production of malondialdehyde. Our data suggest that Pd is toxic to rainbow trout via waterborne contamination near field-measured levels. This study further demonstrated Pd bioavailability and uptake at water-adjacent tissues, adding to our collective understanding of the toxicological profile of Pd. Taken together, our results provide novel insights into the olfactory toxicity in fish following Pd exposure. Integr Environ Assess Manag 2024;20:1407–1419. © 2024 The Authors. Integrated Environmental Assessment and Management published by Wiley Periodicals LLC on behalf of Society of Environmental Toxicology & Chemistry (SETAC).
Key Points
Palladium (Pd) inhibits multiple fish olfaction pathways.
Shifts in water quality did not alter Pd olfactory inhibition.
Effectiveness and continuation rates of the etonogestrel‐subdermal contraceptive implant versus short‐acting contraceptive methods offered at no cost in Campinas, Brazil
Authors: Laporte Montas , Marcelino Ana C. , da Cunha Pereira Paula , Espejo‐Arce Ximena , Juliato Cassia T. , Bahamondes Luis 
Published: February 2024

AbstractObjectivesTo compare the efficacy, reasons for discontinuation and continuation rates of the etonogestrel (ENG)‐subdermal contraceptive implant when offered at no cost, and the basis of free choice versus short‐acting reversible contraceptive (SARC) methods including combined oral contraceptives (COCs), once‐a‐month injectables, vaginal ring, and patch.MethodsWe conducted a prospective study at the University of Campinas, Brazil, involving women aged 18 to 40 years. They were counseled on various contraceptive methods before entering the study and followed up every 3 months for up to 24 months. Satisfaction was assessed using a Likert scale. Survival rates were estimated using the Kaplan–Meier test, and curve comparisons were performed using the log‐rank test.ResultsWe enrolled 609 women including 358/609 women (58.8%) who chose the ENG‐implant and 251/609 (41.2%) who chose SARC methods. Contraceptive failure and all other reasons for discontinuation were significantly higher in SARC users compared to the ENG‐implant users (P < 0.001 and P = 0.002, respectively). The continuation rate was higher among ENG‐implant users (89.9% and 75.4%) compared to SARC methods users (27.2% and 15.9%) up to 1 and 2 years after study initiation, respectively. Satisfaction was high in both groups (>82%).ConclusionsThe ENG‐implant showed higher contraceptive effectiveness and higher continuation rates than SARC methods up to 2 years after study initiation. Furthermore, users from both groups were highly satisfied with their contraceptive. The main reason for discontinuing use of the ENG‐implant was bothersome uterine bleeding, while for SARC methods it was for personal reasons.
Solid organ transplant residency research publication rates and characteristics associated with successful publication
Authors: Melaragno Jennifer I. , Kovac Danielle , Witek Stephanie , Harris Matt , Khalil Karen , Laub Melissa R. , Quan David , Lichvar Alicia B. 
Published: February 2024

AbstractIntroductionPublication rates, characterization, and assessment for predictors of publication in post‐graduate year 2 (PGY2) solid organ transplant (SOT) are lacking.ObjectivesThis study was conducted to determine the publication rate of PGY2 SOT pharmacy resident projects, understand practices surrounding resident research, and assess characteristics of published manuscripts.MethodsAn electronic survey of PGY2 SOT residency programs was distributed. Invitation for participation was sent by email to residency program directors (RPDs), and information related to the PGY2 SOT program, RPDs, research mentors/preceptors, residents, and each research project was gathered for residents graduating between 2016 and 2019. Characteristics influencing publication success were assessed with multivariate logistic regression modeling.ResultsThirty‐eight RPD responses were analyzed (67.8% response rate). All PGY2 SOT programs were American Society of Health‐System Pharmacists (ASHP) accredited, 92% were at academic medical centers, and more than 80% were active over 6 years with a median of 10 (interquartile range [IQR] 5–13) graduated residents. In total, 35/97 (36.1%) of SOT PGY2 research projects were published, 22.7% intend to submit or have a manuscript under revision, and 39.2% will not pursue publication. Of published projects, 81% were in medical journals. Median impact factor was 2.9 (IQR 1.5–2.9). Programs active more than 10 years (odds ratio [OR] 4.0, 95% confidence interval [CI] 1.41–11.17, p = 0.009) and utilization of additional resources (OR 4.2, 95% CI 1.23–14.37, p = 0.022), including availability of a biostatistician/epidemiologist or pharmacy student, were independently predictive of publication. Fifty percent of RPDs rated their programs as either “effective” or “extremely effective” in enabling publication. Perceived barriers to publication, most often continuity of PGY2 SOT involvement after residency, were identified.ConclusionOverall, 36.1% of PGY2 SOT pharmacy resident research projects achieved publication over a 4‐year period at the time of the survey. Years of PGY2 SOT program activity and having additional resources were independently associated with publication.
In silico prediction of ocular toxicity of compounds using explainable machine learning and deep learning approaches
Authors: Zhou Yiqing , Wang Ze , Huang Zejun , Li Weihua , Chen Yuanting , Yu Xinxin , Tang Yun , Liu Guixia 
Published: February 2024

AbstractThe accurate identification of chemicals with ocular toxicity is of paramount importance in health hazard assessment. In contemporary chemical toxicology, there is a growing emphasis on refining, reducing, and replacing animal testing in safety evaluations. Therefore, the development of robust computational tools is crucial for regulatory applications. The performance of predictive models is heavily reliant on the quality and quantity of data. In this investigation, we amalgamated the most extensive dataset (4901 compounds) sourced from governmental GHS‐compliant databases and literature to develop binary classification models of chemical ocular toxicity. We employed 12 molecular representations in conjunction with six machine learning algorithms and two deep learning algorithms to create a series of binary classification models. The findings indicated that the deep learning method GCN outperformed the machine learning models in cross‐validation, achieving an impressive AUC of 0.915. However, the top‐performing machine learning model (RF‐Descriptor) demonstrated excellent performance with an AUC of 0.869 on the test set and was therefore selected as the best model. To enhance model interpretability, we conducted the SHAP method and attention weights analysis. The two approaches offered visual depictions of the relevance of key descriptors and substructures in predicting ocular toxicity of chemicals. Thus, we successfully struck a delicate balance between data quality and model interpretability, rendering our model valuable for predicting and comprehending potential ocular‐toxic compounds in the early stages of drug discovery.
Protective effect of diindolylmethane‐enriched dietary cabbage against doxorubicin‐induced cardiotoxicity in mice
Authors: Natesh Jagadish , Mondal Priya , Penta Dhanamjai , Mukhlis Yahya , Haware Devendra Jaganath , Meeran Syed Musthapa 
Published: February 2024

AbstractChemotherapy with doxorubicin (Dox) can lead to cardiotoxic effects, presenting a major complication in cancer therapy. Diindolylmethane (DIM), derived from cruciferous vegetables like cabbage, exhibits numerous health benefits. However, its clinical application is limited because of low bioavailability and suboptimal natural concentrations in dietary sources. To address this limitation, we developed a processing methodology, specifically fermentation and boiling, to enhance DIM levels in cabbage. High‐performance liquid chromatography (HPLC) analysis revealed a threefold DIM increase in fermented cabbage and a substantial ninefold increase in fermented‐boiled cabbage compared to raw cabbage. To evaluate the clinical implications, we formulated a DIM‐enriched diet and administered it to mice undergoing Dox treatment. Our in vivo results revealed that Dox treatment led to cardiotoxicity, manifested by changes in body and heart weight, increased mortality, and severe myocardial tissue degeneration. Dietary administration of the DIM‐enriched diet enhanced antioxidant defenses and inhibited apoptosis in the cardiac tissue by interfering with mitoptosis and increasing antioxidant enzyme expression. Interestingly, we found that the DIM‐enriched diet inhibited the nuclear translocation of NF‐kB in cardiac tissue, thereby downregulating the expression of inflammatory mediators such as TNF‐α and IL‐6. Further, the DIM‐enriched diet significantly reduced serum cardiac injury markers elevated by Dox treatment. These results suggest that the DIM‐enriched cabbage diet can serve as a complementary dietary intervention for cancer patients undergoing chemotherapy. Further, our research highlights the role of plant‐based diets in reducing treatment side effects and improving the quality of life for cancer patients.
Subjective evaluation of home environment and levels of self‐reported depression in middle to old age: Results from the HCHS study
Authors: Ascone Leonie , Mascherek Anna , Weber Sandra , Fischer Djo , Augustin Jobst , Cheng Bastian , Thomalla Götz , Augustin Matthias , Zyriax Birgit‐Christiane , Gallinat Jürgen , Kühn Simone 
Published: February 2024

AbstractObjectivesThe immediate living environment might, like other lifestyle factors, be significantly related to mental well‐being. The current study addresses the question whether five relevant subjective home environment variables (i.e., protection from disturbing nightlight, daylight entering the home, safety at home, quality of window views, and noise disturbance) are associated with levels of self‐reported depression over and above well‐known sociodemographic and common lifestyle variables.MethodsData from the Hamburg City Health Study (HCHS) were analyzed. In N = 8757 with available PHQ‐9 depression data, multiple linear regression models were computed, with demographic data, lifestyle variables, and variables describing the subjective evaluation of the home environment.ResultsThe model explained 15% of variance in depression levels, with ratings for the subjective evaluation of home environment accounting for 6%. Better protection from disturbing light at night, more daylight entering the home, feeling safer, and perceived quality of the window views, were all significantly associated with lower, while more annoyance by noise was associated with higher levels of self‐reported depression. Results did not differ if examining a sample of the youngest (middle‐aged participants: 46−50 years) versus oldest (70−78 years) participants within HCHS.ConclusionBeyond studying the role of lifestyle factors related to self‐reported depression, people's homes may be important for subclinical levels of depression in middle and older age, albeit the direction of effects or causality cannot be inferred from the present study. The development of a consensus and tools for a standardized home environment assessment is needed.
Assessment of salt tolerance in phytodesalination candidates: Two varieties of Fimbristylis—F. ferruginea and F. tenuicula
Authors: Manasathien Jinnawat , Khanema Piyanut 
Published: February 2024

AbstractPhytodesalination, an environmentally sustainable solution for saline soil challenges, involves identifying salt‐tolerant plants. This study meticulously examined Fimbristylis ferruginea and Fimbristylis tenuicula near the underground salt dome in Khon Kaen, Thailand, revealing unique physicochemical soil properties, morphology, metabolomic responses, and ionic sequestration mechanisms. Despite F. ferruginea’s lower ECe (21.79 vs. 41.46 dS m−1 for F. tenuicula), it excelled in sodium sequestration (504.42 g kg DW−1 vs. 246.32 g kg DW−1). Fimbristylis ferruginea’s roots efficiently locked sodium, facilitated by cyanidin, pelargonidin, and proline—compatible solutes crucial under salinity stress. Conversely, F. tenuicula, within the same genus and environment, responded to salinity stress by elongating roots and stems, enhancing salt storage, and increasing chlorophyll a content. Bioconcentration factor and translocation factor calculations designated F. ferruginea for phytostabilization and F. tenuicula for phytoextraction. This research emphasizes the assessment of salt tolerance in two Fimbristylis species, serving as natural salt reservoirs with low‐cost implications. Remarkably, F. ferruginea dominated, storing up to 50% sodium in its biomass.