bluuebunny/crossref_metadata_2025_split huggingface dataset:
A - 76 Association between Sleep Apnea Risk and Cognitive Performance in Individuals with Type 1 Diabetes (T1D): Evidence from the Glucog Study
Authors: Zuniga-Kennedy Miranda , Hawks Zoë W , Jung Laneé , Hansen Devon , Germine Laura , Chaytor Naomi S 
Published: October 2023

Abstract

Objective
Evidence suggests that individuals with type 1 diabetes (T1D) experience higher rates of sleep apnea compared to the general population, which may contribute to higher rates of cognitive dysfunction in T1D.

Method
206 participants with T1D (mean [range] age = 45.48 [18–84] years, 53.40% female, 60.20% college degree or higher, mean [range] HbA1c = 7.5 [5.1–12.3] %) were recruited from four diabetes centers. Measures included 10 self-administered online cognitive tasks (testmybrain.org) that assessed nonverbal reasoning, visual working memory, cognitive flexibility, processing speed, visual memory, sustained attention, and basic psychomotor speed, as well as the STOP-BANG inventory to assess obstructive sleep apnea (OSA) risk. Correlation coefficients and partial correlations were used to examine the relationship between OSA risk and cognitive performance.

Results
20.39% of the sample was at high risk for OSA. Higher STOP-BANG scores were significantly correlated with poorer performance on digit symbol coding, flicker change detection, matrix reasoning, multiple object tracking, visual paired associates, gradCPT, letter-number switching, and choice reaction time r(204) = −0.15 to −0.42, p &lt; 0.01. After controlling for age, OSA risk was associated with poorer performance on matrix reasoning, pr(203) = −0.16, p = 0.02, and visual paired associates pr(203) = − 0.14, p = 0.04.

Conclusions
Findings revealed an association between OSA risk and poorer performance on measures of nonverbal reasoning and visual memory that persisted after controlling for age. Future research is needed to better understand the mechanisms by which OSA risk impacts cognitive performance in this population.
A - 79 Coping and Psychological Well-Being among Persons with Relapsing–Remitting Multiple Sclerosis: the Role of Self-Efficacy
Authors: Bradson Megan , Thomas Garrett , Arnett Peter A , Strober Lauren 
Published: October 2023

Abstract

Objective
To explore self-efficacy as a possible mediator in the relationship between adaptive coping and psychological well-being (PWB) in persons with relapsing–remitting multiple sclerosis (RRMS).

Method
174 persons with RRMS (95% Female) completed an online survey consisting of psychosocial questionnaires. The COPE Inventory was used to create an adaptive coping composite that accounts for the relative contributions of both active and avoidant coping. Self-efficacy was measured using the General Self-Efficacy Scale. The Ryff Psychological Well-Being Scales captured several domains of PWB: Positive relations with others, autonomy, purpose in life, self-acceptance, and personal growth. The SPSS PROCESS macro was used to test whether self-efficacy mediated the association between adaptive coping and each PWB subscale, using 5000 bootstrap samples to estimate confidence intervals.

Results
In each mediational model, adaptive coping significantly predicted each PWB subscale and self-efficacy (all p’s ≤ 0.001). Self-efficacy significantly predicted each PWB subscale (p ≤ 0.001). After controlling for self-efficacy, the associations between adaptive coping and positive relations with others (indirect effect = 0.021, 95% CI [0.011, 0.033]) and autonomy (indirect effect = 0.019, 95% CI [0.011, 0.028]) became non-significant. The separate associations between adaptive coping and purpose in life (p = 0.004), self-acceptance (p = 0.026), and personal growth (p &lt; 0.001) remained significant, despite controlling for self-efficacy.

Conclusions
Self-efficacy fully mediated the relationships between adaptive coping and positive relations with others and autonomy in our sample of persons with RRMS. Interventions aimed at increasing adaptive coping skills and self-efficacy may improve relations with others and autonomy among persons with MS.
A - 81 Neuroimaging Application to Determine the Prevalence of Neurological Manifestations Amongst Adult Patients with COVID-19: a Systematic Review
Authors: Centeno Carmin A , Tapia Glariangeliz , Castillo Ismael J 
Published: October 2023

Abstract

Objective
Recent reports of central nervous system involvement in Coronavirus Disease- 2019 (COVID-19) have prompted an interest in studying the neurological impact of COVID-19 (e.g., anosmia, headaches, cognitive impairments). This study aimed to evaluate the prevalence of neurologic complications amongst adult patients with COVID-19 implementing structural and functional neuroimaging techniques and to describe the associated neurological manifestations.

Data Selection
A systematic review, following PRISMA guidelines, was conducted to explore literature related to COVID-19 effect on brain structure and functioning. The data for this review was collected from EBSCOHost and ProQuest. Relevant articles were screened according to pre-defined inclusion criteria from December 2019 to March 2022 (patients with COVID-19, structural and functional neuroimaging, and neuroimaging findings associated with COVID-19). Data extraction was performed to obtain relevant information from the selected studies. Two authors independently assessed the quality of the research evidence using the Joanna Briggs Institute (JBI) Critical Appraisal Tool for Prevalence Studies. 36 articles met our inclusion criteria. After the critical appraisal, 16 studies were excluded from the study.

Data Synthesis
Data analysis combined qualitative analysis and descriptive measures for the 20 included articles that reported neuroimaging findings in COVID-19 patients were included. Many of the articles were retrospective observational studies. The most common neurological manifestations were cerebrovascular accidents (18/20; 90%) and white matter abnormalities (7/20; 35%).

Conclusions
Abnormal neuroimaging findings in COVID-19 patients suggest that performing neuroimaging studies in patients in which neurological complications are suspected may be of great importance. Further research should employ functional neuroimaging techniques to identify the neurological manifestations.
A - 83 Associations between Subjective and Objective Cognition, Depression, and Quality of Life in Men Living with HIV
Authors: Collette Christopher , Del Bene Victor A , Kamath Vidyulata , Jacob Alexandra , Fazeli Pariya , Vance David E 
Published: October 2023

Abstract

Objective
In people living with HIV, subjective cognitive dysfunction is widely reported; however, few studies have examined the relationship between subjective cognitive functioning and performance-based measures of cognitive functioning, mood, and quality of life (QoL).

Methods
Men living with HIV (MLWH) (n = 51, mean age = 54 years, 67% Black) completed measures of subjective cognitive functioning (Cognitive Failures Questionnaire; CFQ), objective cognitive performance (HVLT-R, TMT, UFOV, WRAT-3 Reading), health-related QoL (Medical Outcomes Short-Form; SF-36), mood (CES-D), and overall QoL (Control, Autonomy, Self-Realization, and Pleasure Quality of Life Scale; CASP-19). Pearson and Spearman correlation analyses were conducted to examine significant associations between variables. Alpha was set at 0.01 for all analyses.

Results
The CFQ was not significantly correlated with performance on objective cognitive tests. However, significant associations were found between the CFQ and self-reported depression severity (CES-D; r = 0.655, p &lt; 0.001), quality of life (CASP-19; r = −0.642, p &lt; 0.001), and multiple subscales of the SF-36 (all p’s &lt; 0.003). Of note, correlations between the CFQ with SF-36 scales and CASP-19 were no longer significant after controlling for depressive symptoms.

Conclusions
Consistent with prior work, we found that subjective cognitive functioning may inadequately capture the full range of a person’s cognitive functioning status. We extend these findings to a sample of MLWH and further clarify the possible influence that depressive symptoms have on subjective cognitive functioning and self-reported QoL measures. Future studies with larger samples and a more comprehensive neuropsychological battery will be helpful in understanding the full nature of these relationships.
A - 84 Neuropsychological Phenotypes of FDG-PET Identified Corticobasal Degeneration Pathology
Authors: Fernandes David , Coulehan Kelly , Roseman Emily , Lebowitz Brian , Sucich Kai , Preston Thomas , Bangiyev Lev , Franceschi Dinko , Viqar Fawad 
Published: October 2023

Abstract

Objective
Corticobasal degeneration (CBD), a rare neurodegenerative disorder, can present with diverse clinical phenotypes. This qualitative case series examines clinical progression of neuropsychological findings associated with CBD identified pathology on fluorodeoxyglucose-positron emission tomography (FDG-PET).

Method
Three clinically referred older adults underwent neuropsychological assessment prior to and after FDG-PET. All patients reported subjective memory complaints. Patient A: 67-year-old female with swallowing difficulty. Patient B: 83-year-old male with decreased balance. Patient C: 77-year-old male with gait disturbance. Neuropsychological re-evaluations occurred at 64, 19, and 17 months, respectively. Radiological interpretations of FDG-PET hypometabolism were reviewed. Clinically significant changes were defined as &gt;1 standard deviation discrepancy from baseline performance.

Results
Patients A & C had predominant right hemisphere hypometabolism, and Patient B had predominantly left hemisphere hypometabolism. Patient A: hypometabolism for R &gt; L frontoparietal, right temporal and occipital regions. Neuropsychological declines in left fine motor control/speed, attention, visual memory, and semantic fluency. Patient B: hypometabolism for left temporal, frontal, parietal, and occipital regions. Neuropsychological declines in semantic fluency and set-shifting. Patient C: hypometabolism for diffuse right hemisphere, including thalamus and basal ganglia. Neuropsychological declines in verbal learning and memory. There were no significant neuropsychological improvements for Patients A or C. Significant neuropsychological improvement for Patient B was evident for verbal memory and naming.

Conclusions
The present case series highlights the diverse clinical presentation associated with CBD identified pathology on FDG-PET. Further studies are needed to characterize clinical phenotypes of CBD as they relate to quantitative FDG-PET pathology.
A - 88 Parkinson’s Disease and Deep Brain Stimulation (DBS) Device Settings: Effects of Amplitude, Pulse Width, and Frequency on Cognitive Performance
Authors: Ferguson Hayden D , Coolbrith Nicole , Krengel Maxine , Bennett Kazia , Lawson Jordan , Ciccone Keith J , Hohler Anna D , Piryatinsky Irene 
Published: October 2023

Abstract

Objective
Frontal systems decline after DBS for Parkinson’s disease has been consistently reported, with high frequency settings (&gt;130 Hz) correlating with decreased executive functioning and verbal fluency. The present study replicates and expands upon these findings.

Method
Six DBS recipients underwent standardized pre/post-surgical neuropsychological testing. Two-tailed T-tests assessed changes in cognitive scores. Correlational analyses explored relationships between cognitive scores and UPDRS, H&Y, and stimulator settings (amplitude, pulse width, and frequency).

Results
All participants underwent bilateral STN stimulation. Pre/post averages were: UPDRS (43.0 and 26.2) and H&Y (2.7 and 2.3) with average stimulator settings of amplitude (2.7 V), pulse width (60.8 μs), and frequency (151.7 Hz). Pre/post neuropsychological testing revealed significant decline on the Behavioral Dyscontrol Scale (p = &lt;0.01) with an average raw score decline of 3.17 points. All other cognitive scores showed non-significant improvement (p-value range = 0.22–0.89). H&Y change significantly correlated with semantic fluency (r = 0.96). UPDRS change significantly correlated with motoric processing speed (r = 0.91), semantic fluency (r = −0.93), and confrontation naming (r = −0.86). Stimulator amplitude significantly correlated with auditory attention (r = 0.82); simple planning (r = 0.96); and verbal memory (r = −0.86). Stimulator frequency significantly correlated with auditory attention (r = 0.87), simple planning (r = 0.97), and verbal memory (r = −0.96). Simulator pulse width was not significant.

Conclusion
The study examines effects of bilateral STN stimulation on cognitive outcomes in patients with PD. A significant improvement in motor function was accompanied by a significant decline in performance on upper motor bilateral dexterity and inhibition. Correlation analysis shows the relationship between changes in cognition and motor function, as well as the correlation between stimulator settings and specific cognitive functions.
A - 90 Assessment Methods for Anxiety in Epilepsy
Authors: Freglette Cameryn , Barr William 
Published: October 2023

Abstract

Objective
Anxiety is disproportionately common in people with epilepsy, however, the optimal tool to screen for assessment of anxiety in epilepsy has not been definitively established. This study aims to assess if a long questionnaire such as the Minnesota Multiphasic Personality Inventory-2 Restructured Form (MMPI-2-RF) is necessary for identifying and quantifying anxiety symptoms in patients with epilepsy or if the Beck Anxiety Inventory (BAI) will suffice as a screening measure.

Method
Retrospective data were analyzed from a neuropsychology registry of patients with epilepsy (N = 317; 136 male, 181 female). As proposed by Kenfack et al, 2022, patients that scored ≥16 on the BAI were cross tabulated with patients identified by the MMPI-2-RF as having T-scores ≥65 on scales EID (emotional/internalizing dysfunction), RC7 (dysfunctional negative emotions), STW (stress/worry), AXY (anxiety), and RC1(somatic complaints). Multiple chi square tests with alpha set at.05 were performed to examine the relationship between BAI and MMPI-2-RF indices in identifying anxiety in patients with epilepsy.

Results
As shown in Table 1, scores above the cutoff on the BAI were significantly associated with scores falling above the cutoffs for all of the MMPI-2-RF anxiety indices (EID, RC1, RC7, STW, & AXY).

Conclusion
The diagnostic value of the BAI is similar to that of MMPI-2-RF subscales commonly used to assess anxiety. The findings provide support for using the BAI for screening anxiety symptoms in patients with epilepsy undergoing neuropsychological assessment. Keywords: Anxiety, Epilepsy, MMPI-2-RF, BAI.
A - 91 Serial Neuropsychological Evaluations of a Woman with Neuropsychiatric Systemic Lupus Erythematosus and Immunotherapy Treatment
Authors: Greenfield Naomi , McGinley John , Weiss Erica F , Bronshteyn Diana , Facchini Ronda , Stimmel Marnina B 
Published: October 2023

Abstract

Objective
Neuropsychiatric System Lupus Erythematosus (NP-SLE) is a subtype of SLE characterized by chronic or episodic neurologic and/or psychiatric central nervous system features. The neuropsychological profile of NP-SLE is not well-established. Here we present serial evaluations of a woman with confirmed NP-SLE who underwent subsequent medical intervention. This case study adds to the growing body of literature demonstrating the role neuropsychology plays in the care of patients with NP-SLE.

Method
This was an evaluation of a 25-year-old woman with NP-SLE. Initial testing took place inpatient prior to treatment with immunotherapy treatment subsequent evaluations were outpatient at 1 month, 4 months and 8 months post-treatment.

Results
Inpatient evaluation revealed a woman of at least average premorbid abilities with suboptimal performances across cognitive domains including reduced speed of processing and notable difficulty with planning and organization. Evaluation 1 month later evidenced worsening cognitive and motoric performances across tasks which led to adjustment of medical management. Evaluation at 4 months demonstrated a positive trend and some improved cognitive functioning; 8-month evaluation confirmed improvement in global cognition and functioning with suspected return to premorbid abilities.

Conclusions
This case provides an example of NP-SLE neuropsychological profile over time and demonstrates the beneficial impact of correct diagnosis and medical regimen. It also highlights the role of serial neuropsychological assessment in the management of complex neurological disease.
A - 93 The Impact of Motivation on Neuropsychological Performance in Chronic Cannabis Users
Authors: Hirst Rayna , Hopper Jakob , Vaughn Dylan , Sodos Louise , Rosen Alexis , Gretler Julie , Arastu Sana , Pilavjian Haig 
Published: October 2023

Abstract

Objective
Cannabis is one of the most widely used substances, and although the literature shows that it affects users’ cognition, it is unclear how much that impact is affected by factors such as motivation. Previous studies utilizing validity measures showed that user motivation to perform well positively impacts California Verbal Learning Test – II performance, which was higher in cannabis users who completed it immediately after a motivational statement (Macher & Earleywine, 2012). In the present study, the authors altered the order of test administration to further delineate the role motivation plays in cannabis user performance on neuropsychological measures.

Method
Participants (48 cannabis users, 23 nonusers) completed a neuropsychological battery, including performance validity measures, with random assignment to a motivational or neutral condition. The test order was altered to evaluate whether a motivational statement had an effect on any subsequent test administered or a lasting effect throughout the battery.

Results
Analyses revealed significant differences in performance, with users in the motivational condition performing better than users in the neutral condition on the Block Design (p = 0.006, partial eta squared = 0.157) and Digit Symbol Coding (p = 0.011, partial eta squared = 0.137) subtests of the WAIS-III (both indicating large effect sizes). Nonusers in the neutral condition performed better than nonusers in the motivational condition on multiple subtests.

Conclusion
Results indicate that cannabis users exposed to the motivational statement performed better than those given a neutral statement on several neuropsychological tests. Findings suggest that cannabis users can demonstrate better cognitive performance when sufficiently motivated.
A - 95 State of the Science Systematic Review of the Neuropsychology of Solid Organ Transplantation
Authors: Jimenez Tina , Nosker Jennifer , Jones-Medina Jenny , Del Bene Victor , Mullen Christine , Murriel Emily , Randolph Brittney 
Published: October 2023

Abstract

Objective
Organ failure is associated with cognitive dysfunction; however, the acute and longitudinal effects of different types of organ failure and transplantation on cognition have yet to be fully elucidated. This systematic review aimed to identify evidence for key neurocognitive profiles by organ type among pre- and post-transplant patients and identify health and behavior factors that may influence cognition in transplant populations.

Data Selection
PubMed, EMBASE, and PsychInfo database systemic searches were performed. The primary inclusion criteria were adult patients, peer-reviewed articles, full-organ transplant, and neuropsychological test results. Screening and data extraction were performed independently by two authors following PRISMA criteria.

Data Synthesis
A total of 737 abstracts were screened, 237 full-text articles were reviewed for relevance in the second-level screening process, and a total of 125 articles were thoroughly reviewed and included. The number of studies by organ type included the following: liver (62), kidney (30), cardiac (17), lung (12), and multi-organ (4). Available research reported diffuse impairments in liver and cardiac transplant candidates, more circumscribed deficits (i.e., attention, executive functioning, and memory) in kidney transplant candidates, and few cognitive impairments among lung transplant candidates. Post-transplant research showed notable improvement across all organ recipients.

Conclusion
Results appear to be impacted by disease severity and demographic variables, with older age more often associated with worse cognitive performance over time. Results highlight the several literature gaps that can be improved with further transplant neuropsychology research.
A - 97 Anticholinergic Burden Scales Are Not Created Equal: Differential Relationships to Cognition in Parkinson’s Disease
Authors: Kenney Lauren E , Santos Lauren G , Ray Alyssa , Paredes Alfredo A , Ratajska Adrianna M , Eversole Kara , Bowers Dawn 
Published: October 2023

Abstract

Objective
Cognitive changes are common in Parkinson’s disease (PD). While previous research suggests greater anticholinergic medication use relates to worse broad cognition in PD, its domain-specific relationships remain unknown. This study compared three anticholinergic scales to examine their relationship to worse memory and executive function in individuals with PD.

Method
Participants included 493 non-demented individuals with PD (mean age = 65.74, SD = 9.04; mean education = 15.0, SD = 2.79; 72% male; 94% White (non-Hispanic)) from a movement disorders specialty clinic. Medications were identified via chart review. Each medication was scored (0–3) and summed using three scales: Anticholinergic Risk Scale (ARS), Anticholinergic Drug Scale (ADS), Anticholinergic Cognitive Burden Scale (ACBS). Cognitive composites averaged normative z-scores: Executive Function (EF; Trails B, Stroop Color-Word, Letter Fluency) and Memory (HVLT-R and WMS-III Logical Memory delayed recalls). Analyses included Bonferroni-adjusted, bootstrapped Spearman correlations.

Results
The three scales were significantly related, but with only fair agreement (Kendall’s W(2) = 0.37, p &lt; 0.001). Worse memory related to higher cholinergic burden on only the ACBS (r = −0.10, p = 0.02). Exploratory analyses indicated sex differences in the relationship between cognition and anticholinergic burden. For men, worse memory related to higher scores on both the ACBS (r = −0.11, p = 0.04) and ARS (r = −0.11, p = 0.045). For women, higher ACBS scores related to worse EF (r = −0.18, p = 0.03), whereas higher ADS scores related to worse memory and EF (r = −0.18, p = 0.04; r = −0.26, p = 0.002).

Conclusions
Anticholinergic burden scales differentially related to cognitive performance in PD, with only ACBS showing a significant relationship to memory. Exploratory analyses suggest that scales may have differential relationships to memory and EF in men and women.