bluuebunny/crossref_metadata_2025_split huggingface dataset:
A Recent Advance on Phytochemicals, Nutraceutical and Pharmacological Activities of Buckwheat
Authors: Sharma Shweta , Kumar Sahil , Singh Rajesh Kumar 
Published: October 2023

:
Buckwheat, a member of the Fagopyrum genus in the Polygonaceae family, is an
ancient pseudocereal with noteworthy nutraceutical properties that have been relatively less
explored. This crop holds great promise for the future due to its gluten-free protein, wellbalanced
amino acid profile, and the presence of bioactive flavonoids that promote good health.
With its gluten-free nature and a combination of beneficial nutritional components, buckwheat
shows significant potential for a variety of health benefits.
The objective of the present review aims to explore various nutritional and pharmacological
properties of buckwheat.
With the help of various search engines Pubmed, Google and Semantic Scholar, research and
review papers. Data were analyzed and summarized in a comprehensive review.
A fascinating spectrum of nutritional and pharmacological activities of common buckwheat and
Tartary buckwheat were explored such as antidiabetic, anti-inflammatory, neurological
disorders, antiobesity, anticancer, cardiovascular agents and many more.
This review provides a concise overview of the current understanding of the chemical
composition of both common buckwheat and Tartary buckwheat and the captivating spectrum of
pharmacological activity and also underscoring their immense potential for future advancements.
Plant bZIP Proteins: Potential use in Agriculture - A Review
Authors: de Souza Cláudia Regina Batista , Serrão Cleyson Pantoja , Barros Nicolle Louise Ferreira , dos Reis Sávio Pinho , Marques Deyvid Novaes 
Published: October 2023

Abstract:
With global climate changes and the increased demand for food due to expected world
population growth, genetic improvement programs have aimed at producing crops with increased
yield and tolerance to environmental stresses, such as drought, salinity, and pathogens. On the other
hand, genetic improvement programs via biotechnology require candidate genes that confer traits of
interest to be incorporated into improved crops. In this regard, genes encoding transcription factors
(TFs) can be promising since they are proteins that transcriptionally regulate the expression of target
genes related to the most diverse roles in the plant, including defense against stresses. Among
TFs, bZIP (basic leucine zipper) proteins regulate many developmental and physiological processes
in the plant, such as seed formation, fruit ripening, nutrient assimilation, and defense response to
abiotic and biotic stresses. In this review, we aim to highlight the main advances in the potential use
of bZIP TFs in the genetic improvement of crops. We address this potential mainly regarding crop
tolerance to stresses and other agricultural traits, such as increased yield and fruit features.
Construction of Prognostic ceRNA Network Landscape in Breast Cancer to Explore Impacting Genes on Drug Response by Integrative Bioinformatics Analysis
Authors: Sadeghi Mahboubeh , Cava Claudia , Mousavi Pegah , Sabetian Soudabeh , Morowvat Mohammad Hossein 
Published: October 2023

Background:
Breast cancer accounts for 30% of all new female cancers yearly. Bioinformatics
serves us to find new biomarkers and facilitate future experimental research. Exploring a distinct
network of competing endogenous RNA (ceRNA) that includes potential prognostic, diagnostic,
and therapeutic biomarkers is captivating.

Methods:
Differentially expressed lncRNAs, mRNAs, and miRNAs were collected using Gene Expression
Omnibus datasets. DEGs were validated based on TCGA. Functional analysis and pathway
activity were also done. Drug sensitivity analyses were done, and IC50 vs. gene expression plots
were depicted.

Results:
A total of 696 mRNAs, 48 lncRNAs, and, 43 miRNAs were identified to have significant
differential expression in cancerous breast tissue than normal breast tissue samples. Functional analysis
showed significant pathway enrichments in cancer. We found that 13 individual genes,
lncRNAs, and miRNAs, CDC6, ERBB2, EZR, HELLS, MAPK13, MCM2, MMP1, SLC7A5,
TINCR, TRIP13, hsa-miR-376a, hsa-miR-21, hsa-miR-454 were significantly predictive of poor
overall survival and AKAP12, CXCL12, FGF2, IRS2, LINC00342, LINC01140, MEG3,
MIR250HG, NAV3, NDRG2, NEAT1, TGFBR3 and, hsa-miR-29c were associated with favorable
overall survival. We reached a set of five genes (EGR1, NFIB, TGFBR3, SMARCA4, and MCM2)
that exhibit altered expression patterns in breast cancer, resulting in increased susceptibility of cancer
cells to certain drug treatments.

Conclusion:
We successfully made a unique ce-network, providing new clues to understand the
regulatory functions of non-coding RNAs (miRNAs and lncRNAs) in the pathogenesis and prognosis
of breast cancer and will facilitate further experimental studies to develop new biomarkers in the
diagnosis, prognosis and, therapy of breast cancer.
A Review on the Progress of QbD Approach in Nanosystems Optimization: Current Updates and Strategic Applications
Authors: Tripathi Devika , Kumari Jyoti , Rathour Krislay , Yadav Princy , Shukla Vikas , Rai Awani Kumar 
Published: October 2023

:
Nanotechnology has made great strides in developing targeted drug delivery systems over
the past few decades. These systems have garnered attention for their unique biological properties
and ability to deliver drugs in a stable and sustainable manner. Despite these advances, there are still
concerns about quality, efficacy, and safety. Many fabrication techniques still need to be refined to
address the complex structures and non-standard manufacturing processes that can impact the quality
of drug delivery systems. Recently, optimization techniques such as Quality by Design (QbD) have
gained popularity in the pharmaceutical industry. QbD is a structured approach that addresses many
technological and trait-related issues by providing a deep understanding of the product and its
operations. This review examines the current state of QbD in the design of various nano-drug
delivery systems, including lipid nanoparticles, lipid carriers, nano micelles, beaded drug delivery
systems, nanospheres, cubosomes, and novel cosmeceuticals. Various mathematical models and
statistical tests have been used to identify the parameters that influence the physical characteristics of
these nanosystems. Critical process attributes such as particle size, yield, and drug entrapment have
been studied to assess risk factors during development. However, critical process parameters are
often identified through trial and error. This review highlights common material attributes and
process parameters that affect the quality of nano-drug delivery systems. Hence, this survey has disclosed the various material attributes and process parameters, quality variables of different nano-drug
systems. QbD designs such as Central drug composite, Design of experiment, D-optimal Design,
Box-Benkhen Design, and Face center Design in optimizing the nanosystems have also been added.
Conclusively, QbD optimization in nano drug delivery systems is expected to be a time-honored
strategy in the forthcoming years.
An Outlook of Substantial Progress in Nanotechnology Emerged in
Treatment Approaches for Rheumatoid Arthritis
Authors: Parveen Amana , Wal Pranay , Kumar Rai Awani , Wal Ankita 
Published: October 2023

Background:
Rheumatoid arthritis affects roughly 5 out of every 1000 persons, rheumatoid
arthritis is a persistent anarchic ailment with complicated pathophysiology a well-known cause of arthritis-
related stinging apropos nexus, degradation of synovium, the creation of pannus, damage to
bones, and loss of the cartilage. Thus, it is imperative to diagnose and treat rheumatoid arthritis. Due to
rheumatoid arthritis's complexity, early diagnosis is difficult, which makes the treatment difficult.
Moreover, anti- rheumatoid arthritis drugs taken on a long-term basis can damage patients' organs as
well. Due to this, these anti- rheumatoid arthritis medications may cause severe side effects in extraarticular
tissues since they cannot selectively target the affected zone. There has been substantial progress
in the discovery of this disease's pathophysiology and treatment strategy over the past few years,
as well as in developing effective diagnostic methods, early detection, and efficient treatment strategies.
In the rheumatoid arthritis, nanotechnology has come to the fore as a game-changer in effectively
managing many diseases. Various nanotechnology approaches are promising for designing formulations
that can deliver drugs to bone and cartilage in targeted and non-targeted ways like Targeting receptors
on inflammation-related cells (CD44, Scavengers receptors, etc.)

Conclusion:
Nanotechnology is used to treat Rheumatoid arthritis, improve implants and prostheses,
and develop new diagnostic and treatment methods in orthopedic medicine. Many chronic orthopedic
diseases exist, but rheumatoid arthritis is the most common. Several research studies have
found that nanotechnology could deliver targeted drugs, reduce adverse effects on non-target organs,
increase drug concentration in synovial tissues, and slow the progression of immune-mediated
rheumatoid diseases such as rheumatoid arthritis. This review examines how nanotechnology can be
used to diagnose and treat rheumatoid arthritis.
Advancements in Biotechnology and Stem Cell Therapies for Breast Cancer Patients
Authors: Dhoundiyal Shivang , Alam Md Aftab 
Published: October 2023

Abstract:This comprehensive review article examines the integration of biotechnology and stem cell therapy in breast cancer diagnosis and treatment. It discusses the use of biotechnological tools such as liquid biopsies, genomic profiling, and imaging technologies for accurate diagnosis and monitoring of treatment response. Stem cell-based approaches, their role in modeling breast cancer progression, and their potential for breast reconstruction post-mastectomy are explored. The review highlights the importance of personalized treatment strategies that combine biotechnological tools and stem cell therapies. Ethical considerations, challenges in clinical translation, and regulatory frameworks are also addressed. The article concludes by emphasizing the potential of integrating biotechnology and stem cell therapy to improve breast cancer outcomes, highlighting the need for continued research and collaboration in this field.
A Critical Review on the Role of Mechanical Connection Technology in Precast Pipe Pile
Authors: Wang Jintao , Liu Yu , Chong Haoran , He Yuheng , Deng Jian , Ye Jincheng , Li Xuezhi 
Published: October 2023

Background:
With an increase in urbanization, there is a persistent demand for prefabricated
pipe pile connections, which play a crucial part in construction projects. In many engineering
projects that use pipe piles, poor welding quality leads to problems like cracks, deformation,
and detachment of pipe pile joints that affect the safety and stability of the project. Therefore, mechanical
joints have gradually been applied in engineering projects, and exhibit a promising potential
in connecting prefabricated pipe piles.

Objective:
The objective of this study was to present a comprehensive description of the classification,
structural characteristics, and application of mechanical connection devices for precast
pipe piles in recent years.

Methods:
In this study, we conducted a review of the patents related to precast pipe pile mechanical
connection devices and presented the advantages of different joints. Further, we introduced the
structural features, differences, and applications of precast pipe pile mechanical connection devices.

Results:
This study analyzed and compared the different types of mechanical connection devices
and summarized their typical characteristics, including connection form, connection quality, construction
efficiency, and cost. The main problems existing in the development of precast pipe pile
mechanical connection devices were assessed. Subsequently, the development trend of precast
pipe pile mechanical connection devices was forecasted, and the research status and future development
trend of precast pipe pile mechanical connection devices were discussed.

Conclusion:
From the present study, it was found that the mechanical connection of the prefabricated
pipe piles can be classified into two categories based on the joint connection range: end integral
connection and steel bar connection. The end integral connection device has a large connection
area, good connection solidity, and can withstand large loads, which is suitable for large
bridges, tunnels, and other projects. However, for small and medium-sized engineering applications,
the steel-type connection device is simple, easy to use, and has a wide range of applications
that can be adapted to different geological conditions and load requirements. Currently, the application
of prefabricated pipe pile mechanical connections is not widespread, both domestically and
internationally. Thus, there is a need for future development in the prefabricated pipe pile mechanical
connections in terms of material innovation, automation, intelligence, and sustainability.
Nanotechnology-based Nose-to-brain Delivery in Epilepsy: A Novel
Approach to Diagnosis and Treatment
Authors: Khan Javed , Yadav Shikha 
Published: October 2023

Abstract:
Epilepsy is a serious neurological disease, and scientists have a significant challenge in
developing a noninvasive treatment for the treatment of epilepsy. The goal is to provide novel ideas
for improving existing and future anti-epileptic medications. The injection of nano treatment via the
nose to the brain is being considered as a possible seizure control method. Various nasal medicine
nanoformulations have the potential to cure epilepsy. Investigations with a variety of nose-to-brain
dosing methods for epilepsy treatment have yielded promising results. After examining global literature
on nanotechnology and studies, the authors propose nasal administration with nanoformulations
as a means to successfully treat epilepsy. The goal of this review is to look at the innovative application
of nanomedicine for epilepsy treatment via nose-to-brain transfer, with a focus on the use of
nanoparticles for load medicines. When nanotechnology is combined with the nose to brain approach,
treatment efficacy can be improved through site specific delivery. Furthermore, this technique
of administration decreases adverse effects and patient noncompliance encountered with more
traditional procedures.
Perbedaan Kualitas Keripik Bengkuang dan Keripik Kentang
Authors: Megantara I Dewa Gede Unesa , Sudiarta I Nyoman 
Published: October 2023

Penelitian ini diupayakan untuk menjadikan bengkuang sebagai keripik. Penelitian ini bertujuan untuk mengetahui kualitas dari keripik bengkung yang dibandingkan dengan kualitas keripik kentang. Penelitian ini diharapkan dapat meningkatkan nilai ekonomis dari bengkuang dan dapat menghasilkan produk keripik bengkuang yang mempunyai sifat fisik dan organoleptik yang dapat diterima oleh konsumen. Dalam 7 hari, keripik bengkuang dan keripik kentang yang disimpan di wadah tertutup dan disuhu ruang tidak mengalami perubahan mulai dari segi tekstur, aroma, rasa, dan warna. Berdasarkan hasil dari penelitian yang telah dilaksanakan, dapat dinyatakan bahwa keripik bengkuang bisa dijadikan sebagai alternatif pengganti kentang dalam pembuatan keripik. Yang mana, data hasil penelitian yang diperoleh menunjukkan tidak ada perbedaan yang signifikan terkait dengan kualitas antara keripik bengkuang dengan keripik kentang.

This research attempted to make yam as chips. This study aims to determine the quality of yam chips compared to the quality of potato chips. This research is expected to increase the economic value of yam and can produce yam chips which have physical and organoleptic properties that are acceptable to consumers. Within 7 days, yam chips and potato chips stored in closed containers and at room temperature did not change in terms of texture, aroma, taste, and color. Based on the results of the research that has been carried out, it can be stated that yam chips can be used as an alternative to potato in making chips. In which, the research data obtained showed no significant difference related to the quality between yam chips and potato chips.
Pengaruh Harga dan Kualitas Pelayanan Terhadap Kepuasan Konsumen
Authors: Astrawan I Kadek Oka , Sanjaya I Wayan Kiki , Ekasani Kadek Ayu 
Published: October 2023

Penelitian ini bertujuan untuk mengetahui bagaimana pengaruh harga (X1) dan kualitas pelayanan (X2) baik secara parsial maupun simultan terhadap kepuasan konsumen (Y). Penelitian ini dilakukan di Livingstone Cafe & Bakery yang beralamat di Jl. Petitenget No. 88X, Kerobokan Kelod, Kec. Kuta Utara, Kab. Badung, Bali. Penelitian ini dilakukan dari bulan Maret hingga bulan Agustus tahun 2021. Populasi dalam penelitian ini adalah konsumen yang berkunjung ke Livingstone Cafe & Bakery. Metode penentuan sampel pada penelitian ini menggunakan teknik sampling kuota dengan metode roscoe yang mendapatkan sampel berjumlah 30 orang. Jenis penelitian ini adalah penelitian korelasional. Teknik analisis datayang digunakan dalam penelitian ini yaitu analisis regresi linear berganda menggunakan program SPSS versi 25. Simpulan dari penelitian ini yaitu: (1) terdapat pengaruh yang signifikan (p<0,05) secara parsial variabel harga (X1) terhadap kepuasan konsumen (Y).; (2) terdapat pengaruh yang sangat signifikan (p<0,01) secara parsial variabel kualitas pelayanan (X2) terhadap kepuasan konsumen (Y).; (3) terdapat pengaruh yang sangat signifikan (p<0,01) secara simultan variabel harga (X1) dan kualitas pelayanan (X2) terhadap kepuasan konsumen (Y) di Livingstone Cafe & Bakery.

This study aims to determine how the effect of price (X1) and service quality (X2) either partially or simultaneously on consumer satisfaction (Y). This research was conducted at Livingstone Cafe & Bakery which is located at Jl. Petitenget No. 88X, Kerobokan Kelod, Kec. Kuta Utara, Kab. Badung, Bali. This research was conducted from March to August 2021. The population in this study were consumers who visited Livingstone Cafe & Bakery. The method of determining the sample in this study used a quota sampling technique with the Roscoe method which obtained a sample of 30 people. This type of research is correlational research. The data analysis technique used in this study is multiple linear regression analysis using the SPSS version 25 program. The conclusions from this study are: (1) there is a significant effect (p <0.05) partially the price variable (X1) on consumer satisfaction ( Y).; (2) there is a very significant effect (p<0.01) partially service quality variable (X2) on customer satisfaction (Y); (3) there is a very significant effect (p<0.01) simultaneously variable price (X1) and service quality (X2) on consumer satisfaction (Y) at Livingstone Cafe & Bakery.
Pengaruh Promosi dan Harga terhadap Keputusan Pembelian Melalui Online Travel Agent
Authors: Andriani Dewa Ayu , Arianty A.A.A Arun Suwi , Suwintari I Gusti Ayu Eka 
Published: October 2023

Penelitian ini bertujuan untuk mengetahui pengaruh promosi dan harga terhadap keputusan pembelian melalui online travel agent di Hotel Prama Sanur Beach Bali. Teknik sampling dalam penelitian ini menggunakan teknik purposive sampling dengan teknik yang diambil adalah sampel kuota. Teknik pengumpulan data yang digunakan dalam penelitian ini adalah kuesioner sebanyak 188 responden, wawancara dan dokumentasi. Dalam penelitian ini menggunakan metode penelitian dengan teknik analisis, meliputi: uji validitas dan reliabilitas, analisis regresi linier berganda, analisi koefisien determinasi dan pengujian hipotesis melalui uji T dan uji F. Hasil penelitian dan pembahasan menyimpulkan bahwa terdapat pengaruh secara parsial dan signifikan antara promosi dan harga terhadap keputusan pembelian di Hotel Prama Sanur Beach Bali dengan nilai signifikan 0,05 (0,000 < 0,05). Promosi dan harga memiliki pengaruh sebesar 76,5% terhadap keputusan pembelian sisanya 23,5% dipengaruhi oleh variabel lain.

This study aims to determine the effect of promotion and price on purchasing decisions through online travel agents at Hotel Prama Sanur Beach Bali. The sampling technique in this research used a purposive technique The sampling technique used is quota sampling. Data collection technique used in this research was a questionnaire of 188 respondents, interviews and documentation. In this study, research methods were used with analysis techniques, including: validity and reliability tests, linear regression analysis multiplex, analysis of the coefficient of determination and hypothesis testing via T test and test F. The results of the research and discussion conclude that there is a direct influence partial and significant relationship between promotion and price on purchasing decisions in Hotel Prama Sanur Beach Bali with a significant value of 0.05 (0.000 < 0.05). Promotion and price has an influence of 76.5% on the remaining purchasing decisions 23.5% is influenced by other variables.
Dose effect and duration of action of liposomal bupivacaine administered as a perineural analgesic in a reversible and adjustable frog-pressure model of equine lameness
Authors: Dockery Allison , Beasley Brian , Goldberg Molly , Aguirre Gabrielle , Moorman Valerie J. 
Published: October 2023

Abstract

OBJECTIVE
To determine the dose effect of peri-neural liposomal bupivacaine (LB) in an induced forelimb lameness model.

ANIMALS
12 clinically normal adult horses.

METHODS
A randomized cross-over design was performed with 1 limb receiving saline and the other LB: low dose (6), high dose (6). Lameness was induced in 1 forelimb using a frog-pressure model. In the lame limb, peri-neural injection of the palmar nerves at the proximal sesamoid bones was performed using saline, low dose LB (0.25 mg/kg) (LDLB), or high dose LB (0.5mg/kg) (HDLB) in random order with a 1-week washout period between treatments. Distal limb swelling, mechanical nociceptive thresholds (MNT), and objective lameness data were collected before and up to 72 hours after peri-neural anesthesia. Data analysis was performed with mixed model ANOVA, equality of medians test, and Kaplan Meier survival analysis.

RESULTS
Compared with baseline, horses treated with LDLB and HDLB had improvements in MNT and lameness (P < .001). In the LDLB group, the median duration of analgesia was 4.5 hours (range = 3–6 hours) and the median return to lameness was 7 hours (range = 4–24 hours). In the HDLB group, the median duration of analgesia was 12 hours (range = 4–48 hours) and the median return to lameness was 9 hours (range = 3–48 hours). Mild to moderate swelling was identified in 11/12 (92%) LB limbs.

CLINICAL RELEVANCE
Both LDLB and HDLB resulted in loss of skin sensation and improvement of lameness. There was high variability among horses in duration of action for both doses.