bluuebunny/crossref_metadata_2025_split huggingface dataset:
Case report of a family with hereditary inclusion body myopathy with VCP gene variant and literature review
Authors: Asadauskaitė Greta , Vilimienė Ramunė , Augustinavičius Vytautas , Burnytė Birutė 
Published: December 2023

BackgroundMissense VCP gene variants lead to a disruption in protein homeostasis causing a spectrum of progressive degenerative diseases. Myopathy is the most frequent manifestation characterized by slowly progressing weakness of proximal and distal limb muscles. We present a family with myopathy due to c.277C &gt; T variant in VCP gene.Case presentationThe patient‘s phenotype includes symmetrical muscle wasting and weakness in the proximal parts of the limbs and axial muscles, a wide based gait, lordotic posture, positive Gowers’ sign, mild calf enlargement, impaired mobility, elevated CK, and myopathy in proximal limb muscles. Whole body MRI revealed fatty replacement, predominantly affecting right vastus intermedius and medialis, gastrocnemius and soleus in calf, abdomen wall and lumbar muscles. Next-generation sequencing analysis revealed a pathogenic heterozygous variant c.277C &gt; T (p.(Arg93Cys)) in exon 3 of the VCP gene. Segregation analysis showed that the detected variant is inherited from the affected father who developed symptoms at 60.ConclusionThe patients described experienced muscle wasting and weakness in the proximal and distal parts of the limbs which is a common finding in VCP related disease. Nevertheless, the patient has distinguishing features, such as high CK levels, early onset of the disease, and rapid mobility decline.
Case report: 177Lu DOTA-TATE: a new scheme for the treatment of prostate neuroendocrine cancer
Authors: Yu Xin-yuan , Zhu Yu-qin , Liu Xin , Tian Rong , Chen Jun-jie , Liu Guo-qing , Yang Dong-yu , Zhang Xue-ping , Li Bao , Zhao Hong-jun , Li Xiao 
Published: December 2023

BackgroundMost instances of small cell carcinoma originate from the lungs, while the gastrointestinal tract serves as a secondary site. Only a minuscule proportion of cases manifest within the urogenital system. Prostate small cell carcinoma (SCCP) represents an exceedingly uncommon pathological subtype within the realm of prostate cancer, displaying significant rarity in clinical settings. This scarcity has resulted in a paucity of adequate foundational and clinical research for SCCP treatment. While investigations have unveiled a certain therapeutic efficacy of radiotherapy and chemotherapy for SCCP, clinical practice has revealed suboptimal treatment outcomes. We hereby present a case report detailing the utilization of 177Lu-DOTA-TATE in the treatment of SCCP, aiming to investigate the therapeutic efficacy of 177Lu-DOTA-TATE for SCCP.Case presentationA male patient in his 80s presented with elevated prostate-specific antigen (PSA) levels and underwent a biopsy that revealed prostate adenocarcinoma. The patient received CAB (bicalutamide + goserelin) therapy. One year later, disease progression was detected, and a second biopsy confirmed the presence of prostate small cell carcinoma. Following the diagnosis of prostate small cell carcinoma, the patient underwent two cycles of 177Lu-DOTA-TATE treatment. Subsequent to the treatment, the original lesions showed shrinkage, metastatic lesions disappeared, and there was significant improvement, approaching complete remission.ConclusionSCCP exhibits a high degree of malignancy and aggressive invasiveness, currently lacking effective therapeutic modalities. The treatment course of this patient serves as compelling evidence for the efficacy of 177Lu-DOTA-TATE in managing SCCP, thereby opening new avenues for future SCCP treatments.
Meta-analysis of Molteno glaucoma implants and Ahmed glaucoma valves: insights into efficacy and safety for complex glaucoma
Authors: Raja Adarsh , Bhimani Sunaina , Alim Ur Rahman Hafsah , Salman Madiha , Saeed Shaikh Afrah , Raja Sandesh , Zafar Sayeed Bushra , Feroze Ahsan , Ahmed Muhammad 
Published: December 2023

BackgroundGlaucoma is a leading cause of irreversible blindness globally and for decades, Molteno and Ahmed glaucoma implants, operating on different mechanisms, have been used to treat complicated glaucoma with varying success.ObjectiveTo assess the safety and efficacy of the Molteno glaucoma implant (MGI) versus the Ahmed glaucoma valve (AGV) in patients with complicated glaucoma.MethodsWe comprehensively searched PubMed, Google Scholar, Cochrane Library and Science Direct) from inception till July 2023 and studies comparing patients with MGI and those with AGV in patients with complicated glaucoma. The primary outcome was intra-ocular pressure reduction at different time intervals. Secondary outcomes included surgical success rate, hypertensive phase, anti-glaucoma medication (AGM) and total complications. ResultsIn this meta-analysis, four studies were included with a patient population of 257 with refractory, neovascular or advanced uncontrolled glaucoma. Postoperative intra-ocular pressure reduction did not show significant difference between the two groups (MD: -1.34, 95% CI [-2.78, 0.09]). From the secondary outcomes, surgical success rate (RR: 0.88, 95% CI [0.51,1.53]), hypertensive phase (RR: 0.74, 95% CI [0.39,1.40]) were insignificant. Postoperative anti-glaucoma medication (MD: -0.07, 95% CI [-0.79, -0.65] and total complications (RR:1.36, 95% CI [1.07, 1.72]) were significant. ConclusionNo significant difference was observed between the patients with MGI and AGV for the primary outcome. From the secondary outcome, AGV was associated with reduced anti-glaucoma medication use and significantly lowered the number of complications.Systematic review registrationhttps://www.crd.york.ac.uk/prospero/display_record.php?RecordID=475539, identifier CRD42023475539.
A phase I study to evaluate the safety, tolerability, and pharmacokinetics of a novel, potent GABA analog HSK16149 in healthy Chinese subjects
Authors: Chen Qian , Wu Qingqing , Song Rong , Wang Yating , Zhang Mengqi , Li Fangqiong , Zeng Weifang , Wang Wei , Jia Jingying , Yu Chen , Liu Yanmei 
Published: December 2023

Purpose: HSK16149 is a novel, potent gamma-aminobutyric acid (GABA) analog for the treatment of neuropathic pain. This study aimed to evaluate the safety, tolerability, and pharmacokinetics of HSK16149 after single and multiple doses in healthy Chinese subjects.Methods: The randomized, double-blind, placebo-controlled study comprised two parts: SAD (single ascending-dose study) and MAD (multiple ascending-dose study). A total of 122 healthy subjects were enrolled in this study. HSK16149 capsule or placebo was administered as the protocol required. The safety of the drug was evaluated through clinical examinations and adverse events. Blood and urine samples were collected at the designated time intervals for pharmacokinetic analysis.Results: Subjects were generally well tolerated after HSK16149 administration and the most common treatment-emergent adverse event (TEAEs) was dizziness, which was expected based on the mechanism of action of HSK16149. In SAD, AUC and Cmax were shown to have a dose-proportional relationship in the dose range of 5-120 mg. The t1/2 of HSK16149 is 3.7-6.4 h. In MAD, after a single and multiple administration of 15-80 mg, AUC and Cmax are proportional to the increased dose of HSK16149, and the accumulative ratios of AUC and Cmax at steady-state were 1.05–1.44 and 1.07–1.36, respectively, indicating that HSK16149 only accumulated slightly after repeated administration.Conclusion: HSK16149 was well tolerated in healthy Chinese subjects. Based on the safety and pharmacokinetic data, 80 mg twice daily (BID) was suggested as the highest target dose for further clinical development.Clinical Trial Registration:http://www.chinadrugtrials.org.cn, identifier CTR20182535 and CTR20191317
Does justice matter in voice? Inclusive leadership and employee voice: the moderating role of organizational justice perception
Authors: Qi Lei , Xu Yuping , Liu Bing 
Published: December 2023

IntroductionAs a distinctive form of relational leadership, the impact of inclusive leadership on employee work behavior has been widely considered by scholars. The purpose of this study was to examine the positive effects of inclusive leadership on employee voice (promotive voice and prohibitive voice), and the moderating role of organizational justice perception (distributive justice, procedural justice, and interactional justice) on such positive effects.MethodsBased on social exchange theory, this study used a multi-wave and multi-source survey to obtain data from 258 subordinates and 52 team leaders from construction companies located in China.ResultsThe results showed that inclusive leadership was positively related to promotive voice and prohibitive voice. Distributive justice and interactional justice would strengthen the positive relationship between inclusive leadership and promotive voice. Distributive justice, procedural justice, and interactional justice would strengthen the positive relationship between inclusive leadership and prohibitive voice.DiscussionFirst, this study examined the impact of inclusive leadership on employee voice, emphasized the importance of inclusive leadership as the core of relational leadership, and provided guidance for improving employee promotive and prohibitive voice. Second, this study conceptualized organizational justice perception as distributive justice, procedural justice, and interactional justice, comprehensively considered the impact of the three dimensions of justice perception on the effectiveness of inclusive leadership, and provided specific reference for employee management practice from the perspective of justice.
Prevalence of depression in junior and senior adolescents
Authors: Zhang Jing , Liu Dehuan , Ding Linwei , Du Guankui 
Published: December 2023

BackgroundDepression affects the development of adolescents and makes it difficult for them to adapt to future life. The purpose of this study was to elucidate the population characteristics of adolescent depression.MethodsThis study measured depression based on the Patient Health Questionnaire-9 items and sociodemographic questionnaire. A total of 8,235 valid questionnaires were collected from six schools in Haikou and Qionghai, Hainan Province, covering the ages of 13 to 18. The questionnaires included high schools with multiple levels, including general high schools, key high schools, and vocational high schools. Latent category analysis (LCA) was used to identify potential categories of depressive symptoms among adolescents. Latent Class Analysis (LCA) was used for determining depressive symptom latent categories and their proportional distribution among adolescents.ResultsLCA analysis divided the data into 3 categories, namely no depression, low depression, and high depression groups. The percentage of the high depression group was 10.1%, and that of the low depression group was 48.4%. The Jorden index was greatest for a PHQ-9 score of 14.5. The 1st grade of junior middle school students entered the high and low depression groups 1.72 and 1.33 times more often than seniors. The number of the 1st grade of high school students included in the high and low depression groups was 1.55 and 1.42 times of the 3rd grade of high school students group. The detection rate of the high depression group of vocational school adolescents was 13.5%, which was significantly higher than that of key high schools (9.6%) and general high schools (9.0%).ConclusionThis study found that 1st grade of junior middle school students and the 1st grade of high school students were more likely to fall into depressive conditions. Moreover, Adolescent girls require more attention than boys. Vocational school students need more psychological guidance.
Perspectives of parents of adolescents with repeated non-suicidal self-injury on sharing their caretaking experiences with peers: a qualitative study
Authors: Qin Yuan , Wu Dongmei , Liu Jiao , Peng Jianyan , Li Chunya 
Published: December 2023

BackgroundThe prevalence of non-suicidal self-injury among adolescents has increased over the years. Most parents, however, are poorly informed and confused about this behavior. Sharing caretaking experiences with parents in similar situations seems to be beneficial. Nevertheless, few researchers have explored the views of parents who share their caretaking experiences with peers.AimThis study aimed to investigate the perspectives of parents of adolescents with repeated non-suicidal self-injury on sharing their caretaking experiences with peers as well as the motivations for and barriers to this behavior.MethodsThis qualitative study adopted a purposive sampling method. Participants (16 mothers and 2 fathers) were recruited from the mental health center of a tertiary hospital in Chengdu, Sichuan, China. A total of 18 semistructured face-to-face individual interviews were conducted. All interviews were audio-recorded and analyzed thematically using NVivo 11.ResultsThree themes and nine subthemes were identified: (1) sharable caretaking experiences: reflection and transformation, self-emotional management, and diversified support; (2) motivations for sharing: empathy, reciprocity, and meaning; and (3) barriers to sharing: inadequate knowledge, low self-identity, and concerns for children.ConclusionParents accumulate a wealth of experience during their long-term care of adolescents with repeated non-suicidal self-injury. Although most parents are willing to share their caretaking experiences with peers, there are several barriers. Therefore, in order to increase parents’ motivation to share, psychological education is necessary.
Symptoms characteristics of personality disorders associated with suicidal ideation and behaviors in a clinical sample of adolescents with a depressive disorder
Authors: Gifuni Anthony Joseph , Spodenkiewicz Michel , Laurent Geneviève , MacNeil Sasha , Jollant Fabrice , Renaud Johanne 
Published: December 2023

IntroductionPathological personality traits have repeatedly been identified as important risk factors for suicidal ideation and behaviors. Moreover, impulsive-aggressive traits, have shown a consistent association with suicidal behaviors across the lifespan. Adolescence represents a critical period for the emergence of different personality traits, mood disorders, and suicidal behaviors, but the relationship between these variables remain poorly understood.MethodsThese variables were examined in a cross-sectional case–control design involving three groups: 30 adolescents with a depressive disorder and past suicide attempt (Mean Age = 16.2, Females = 26), 38 adolescents with a depressive disorder but without past suicide attempt (Mean age = 16.0, Females = 29), and 34 healthy adolescent controls (Mean age = 15.2, Females = 22). Suicidal ideations were indexed using Suicidal Behavior Questionnaire (SBQ-R), psychiatric disorder assessed using a semi-structured questionnaire (K-SADS-PL), depressive symptoms with the Beck Depressive Inventory (BDI), symptoms characteristics of personality disorders with the Scheduled Clinical Interview for the DSM-IV (SCID-II) screening questionnaire, and impulsivity with the Barratt Impulsivesness Scale (BIS).ResultsFindings showed that impulsivity (F = 11.0, p &lt; 0.0001) and antisocial symptoms characteristics of personality disorders (p &lt; 0.001, d = 0.70) displayed the most robust association with adolescent suicide attempts. Borderline symptoms characteristics of personality disorders did not discriminate attempters from non-attempters but presented high correlations with suicidal ideation and depression severity. In an item-wise analysis, suicide attempt status was uniquely correlated with symptoms characteristics of an antisocial personality disorder. Suicide attempt status also correlated with non-suicidal self-injury and a chronic feeling of emptiness.DiscussionThe caveats of this cross-sectional study include the stability of symptoms characteristics of personality disorders in adolescence and the limited sample size. In sum, suicidal behaviors were characteristically correlated with increased impulsivity and antisocial symptoms characteristics of personality disorders, but other symptoms characteristics of personality disorders were relevant to adolescent depression and suicidal ideation. Understanding the emergence of symptoms characteristics of personality disorders and suicidal behaviors in a developmental context can ultimately inform not only the neurobiological origin of suicidal behaviors, but also provide new avenues for early detection and intervention.
Forecasting daily COVID-19 cases with gradient boosted regression trees and other methods: evidence from U.S. cities
Authors: Sen Anindya , Stevens Nathaniel T. , Tran N. Ken , Agarwal Rishav R. , Zhang Qihuang , Dubin Joel A. 
Published: December 2023

IntroductionThere is a vast literature on the performance of different short-term forecasting models for country specific COVID-19 cases, but much less research with respect to city level cases. This paper employs daily case counts for 25 Metropolitan Statistical Areas (MSAs) in the U.S. to evaluate the efficacy of a variety of statistical forecasting models with respect to 7 and 28-day ahead predictions.MethodsThis study employed Gradient Boosted Regression Trees (GBRT), Linear Mixed Effects (LME), Susceptible, Infectious, or Recovered (SIR), and Seasonal Autoregressive Integrated Moving Average (SARIMA) models to generate daily forecasts of COVID-19 cases from November 2020 to March 2021.ResultsConsistent with other research that have employed Machine Learning (ML) based methods, we find that Median Absolute Percentage Error (MAPE) values for both 7-day ahead and 28-day ahead predictions from GBRTs are lower than corresponding values from SIR, Linear Mixed Effects (LME), and Seasonal Autoregressive Integrated Moving Average (SARIMA) specifications for the majority of MSAs during November-December 2020 and January 2021. GBRT and SARIMA models do not offer high-quality predictions for February 2021. However, SARIMA generated MAPE values for 28-day ahead predictions are slightly lower than corresponding GBRT estimates for March 2021.DiscussionThe results of this research demonstrate that basic ML models can lead to relatively accurate forecasts at the local level, which is important for resource allocation decisions and epidemiological surveillance by policymakers.
Transforming urban mobility with internet of things: public bus fleet tracking using proximity-based bluetooth beacons
Authors: Elijah Olakunle , Keoh Sye Loong , bin Abdul Rahim Sharul Kamal , Seow Chee Kiat , Cao Qi , bin Sarijari Mohammad Adib , Ibrahim Noor Farizah , Basuki Achmad 
Published: December 2023

In today’s fast-paced world, efficient and reliable public transportation systems are crucial for optimising time and reducing carbon dioxide emissions. However, developing countries face numerous challenges in their public transportation networks, including infrequent services, delays, inaccurate and unreliable arrival times, long waiting time, and limited real-time information available to the users. GPS-based systems have been widely used for fleet management, but they can be a significant infrastructure investment for smaller operators in developing countries. The accuracy of the GPS location can be easily affected by the weather condition and GPS signals are susceptible to spoofing attacks. When the GPS device is faulty, the entire location traces will be unavailable. This paper proposes the use of Internet-of-Things (IoT)-enabled Bluetooth Low Energy (BLE) systems as an alternative approach to fleet tracking for public bus service. The proposed approach offers simplicity and easy implementation for bus operators by deploying BLE proximity beacons on buses to track their journeys, with detection devices using Raspberry Pi (RPi) Zero strategically placed at terminals and selected stops. When the bus approaches and stops at the bus stops, the BLE advertisements emitted by the proximity beacons can be reliably detected by the RPi Zero. Experiment results show that the BLE signals can be detected up to 20 m in range when the RPi Zero is placed inside a metal enclosure. The location of the bus is then sent to the cloud to estimate the arrival times. A field trial of the proposed IoT-based BLE proximity sensing system involving two public bus services in southern Malaysian cities, namely, Johor Bahru, Iskandar Puteri and Kulai is presented. Based on the data collected, a bus arrival time estimation algorithm is designed. Our analysis shows that there was a 5–10 min reduction in journey time on public holidays as compared to a normal day. Overall, the paper emphasises the importance of addressing public transportation challenges. It also describes the challenges, experience, and mitigation drawn from the deployment of this real-world use case, demonstrating the feasibility and reliability of IoT-based proximity sensing as an alternative approach to tracking public bus services.
A new approach to understanding the role of gasotransmitters in the development of chronic generalized periodontitis
Authors: Leonteva A. V. , Blinova A. V. , Chervinets Yu. V. , Rumyantsev V. A. , Chervinets V. M. 
Published: December 2023

Relevance. Recent studies investigating the role of the microbial gaseous substances (O2, N2, CO2, CH4, NO, CO, H2S) indicate not only in the regulation of the host's metabolic activity and the functioning of its nervous system, in particular but also their participation the pathogenesis of some diseases. However, there is scarce data in the national and international literature on the production of gas signaling molecules by the oral microbiota (Streptococcus spp. and Staphylococcus spp.) and the changes in the gas composition during the development of chronic inflammatory periodontal diseases.Material and methods. The study included 69 people. The main group included 36 patients aged 35 to 67 years with clinically confirmed moderate chronic generalized periodontitis. The control group included 33 patients aged 27 to 55 without periodontal disease. The samples from the back of the tongue were the study material. The gas chromatography determined the production of gas signaling molecules using the Khromatek-crystal 5000.2 device. The measurement of the amount of released gases was in % (for O2, N2) and ppm (0.001 mg/mL) for other gas molecules (CO2, CH4, NO, CO, H2S).Results. The metabolic activity of streptococci only for the production of NO (p = 0.002) and CO (p = 0.008) appeared to have a statistically significant difference. In periodontal inflammation, there was practically no NO emission by Streptococci spp., and the concentration of CO was ten times higher than in the group of healthy individuals. The difference in the number of other signaling gas molecules was not statistically significant (p > 0.05) in healthy people and patients with chronic generalized periodontitis.In the production of gasotransmitters among Staphylococcus spp., N2 production (p = 0.007, increasing in the comparison group) was statistically significantly different. As in the streptococcal sampling, the amount of CO significantly increased in periodontal inflammation. Certain species of staphylococci showed a significant decrease in the production of the entire gas molecule range in the main group. At the same time, unlike Streptococcus spp., Staphylococcus spp. absorbed a much higher amount of nitric oxide in chronic periodontitis.Conclusion. In patients with chronic generalized periodontitis and inflammation, the oral microbiota is poorly active and produces a low concentration of gasotransmitters, so they cannot participate in inflammatory process reduc-tion, thereby contributing to the progression of the disease.