bluuebunny/crossref_metadata_2025_split huggingface dataset:
Preparation and Characterization of Carvedilol Solid Dispersion by Kneading Method
Authors: Ali Q. Hatem  , Wedad K. Ali  
Published: October 2023

Solid dispersion using hydrophilic carrier is one of the approaches that has a potential to increase solubility, dissolution rate and consequently the oral bioavailability of poorly-water soluble drugs. In this study, class II drug "Carvedilol" (CVD) was used because of its poor solubility, it serves as a model drug that contributes to irregular dissolution and limited bioavailability. CVD: PVP K30 solid dispersion formulations SD1, SD2 and SD3 were prepared by kneading method at different weight ratios ,1:1; 1:2 and 1:4 respectively and evaluated for drug content, solubility and dissolution rate. Kneading method enhances the stability of drugs and suitable for processing thermolabile substances. The optimum solid dispersion ratio was characterized also for drug-carrier interaction by FTIR spectroscopy, and crystallinity by SEM and PXRD and compared with physical mixture and pure drug powder.
The results showed that the solubility of carvedilol increased by increasing the proportion of PVP K30 used in the dispersion of the drug. On the other hand, dissolution study revealed a significant enhancement in the dissolution rate of the drug using solid dispersion compared to pure drug and physical mixture. X-ray diffraction of the solid dispersion suggest that the drug's transformation from crystalline to amorphous form may be responsible for the observed improvement in dissolving rate. The carvedilol solid dispersion improved the solubility and dissolution, which depend on the carrier concentration ratio. The dissolution of drugs increased with an increase in carrier content. The studies of PXRD, SEM, and FTIR revealed the amorphous nature of the drug in solid dispersion. The solid dispersion by kneading approach using PVP K30 as a carrier is a potential method for improving CVD's solubility and dissolution rate.
Determination of Some Organic and Inorganic Nutritional Constituents in Beta Vulgaris Roots Prepared in Different Methods
Authors: Wathiq A. Al-Hachami  
Published: October 2023

The nutritional value of the roots of Iraqi Beta vulgaris plant that have been prepared using several conventional techniques will be evaluated in the current research. One of the best and most important nutritional sources of iron, nitrate of nitrogen, magnesium, potassium, ascorbic acid, and folic acid is the juice of beta vulgaris roots.
Spectrophotometric techniques like UV-Visible, HPLC, and AAS have been used to estimate the levels of some organic and inorganic nutritional constituents and determine the level of the nitrate ion using an ion selective electrode technique in the prepared beta vulgaris root juice. The concentration of these organic and inorganic components varies depending on how the Beta vulgaris juice is prepared. The roots of Beta vulgaris have been processed in four different ways.
Ascorbic acid content is greatest in the prepared sample with sodium chloride (4.124 mg in 200 mL), while the sample treated with acetic acid has a high concentration of Betalains (10.96 mg in 200 mL) and folic acid (5.736 mg in 200 mL).
The potassium (552 mg in 200 mL) and magnesium (54 mg in 200 mL) concentrations in juice from the acetic acid-treated sample were relatively higher than those obtained from other methods, whereas the prepared sample with NaCl has a high concentration of NO3- (616 mg in 200 mL) and the prepared sample with cool water has a high concentration of iron (0.75 mg in 200 mL).
Formulation and Evaluation of Herbal Lipstick Containing Saffron as a Natural Colorant
Authors: Mouna A  , Ashok Kumar BS  , Nandeesh R  , Lakshman K  , Naveen Simon  
Published: October 2023

Ancient peoples were using lipstick which was made by natural sources to protect and to increase the beauty of lips. Herbal lipstick ingredients provide pigments, antioxidants, waxes, oils, fragrance and preservatives. Saffron used to look younger and brighter and also used to treat acne, wounds and skin diseases.
The herbal lipstick was formulated by using white bees wax, soft paraffin, coconut oil, almond oil, vanilla essence, orange juice, lemon juice and natural colorant saffron. Formulated lipstick was subjected to evaluation by different parameters like breaking point, softening point, melting point, surface anomalies, aging stability, perfume stability, solubility test and pH. Our formulated showed ideal properties of lipstick like spreading, shining and smoothness of lips after application. It was concluded that this herbal lipstick has better option to women with minimal side effects and further detailed studies are required to assess for better efficacy.
Preparation and Evaluation of Hydrogel Containing Prednisolone Nanoparticles
Authors: Walaa A. Saihood  , Hayder K. Abbas  
Published: October 2023

Currently, nanoparticles technology is well known and it used to augment the rate of drug dissolution and considerably increased bioavailability. Nanoparticles have been combined with hydrogel to form nanoparticle-hydrogel hybrid system as a substitute to conventional dosage forms.
The goal of this study is to prepare an effective hydrogel form containing prednisolone nanoparticles as a hybrid biomaterial system for transdermal application. Six hydrogel formulations containing prednisolone nanoparticles were prepared and characterized for particle size, entrapment efficiency, physical appearance, pH, drug content, spreadability test, viscosity, in-vitro drug release and ex-vivo diffusion. The results showed that the all preparations in the nanometer size and the drug content of prednisolone in hydrogel was ranged from 96.24% to 99.15% and there was a significant enhancement (p<0.05) in drug release and permeation from the prepared nanoparticles -hydrogel formulas when compared with plain hydrogel of prednisolone. From this study, it can be concluded that nanoparticle-hydrogel system could be a possible drug delivery technology for transdermal application of prednisolone drug.
Outubro/2023
Authors: Neves Fabricio Souza 
Published: October 2023

Artigo original
ANÁLISE DA COMPREENSÃO SOBRE O TRANSTORNO DO ESPECTRO AUTISTA DE PROFISSIONAIS DE CENTROS DE EDUCAÇÃO INFANTIL DO MUNICÍPIO DE CRICIUMA/SC
Costa RRN, Lin J, Gonçalves CL.............................................................................................................24

Artigo de revisão
CÂNCER: UMA REVISÃO INTEGRATIVA POR ESTUDANTES DE MEDICINA
Boaretto N, Costa e Silva GA, Luiz FAF, Natividade LM, Massarotto LJM, Sá LPNB, Cabral N, Aguiar CBNM......................................................................................................................................................31

Artigo livre
O ANATÔMICO
Cunha VJL................................................................................................................................................38
Cultura starter em patê de pintado amazônico (Pseudoplatystoma fasciatum x Leiarius marmoratus): Desenvolvimento e determinação do prazo comercial
Authors: Porfírio Talitha Maria , Arruda Iara Oliveira , Alves Ariane Barbosa , Nascimento Edgar , Lanzarin Marilu , Ritter Daniel Oster 
Published: October 2023

O presente estudo teve como objetivo elaborar um patê de pintado amazônico adicionado de cultura starter (Staphylococcus xylosus e Pediococcus pensosaceus), realizar sua caracterização e determinar o prazo comercial e desenvolver um modelo matemático preditivo para verificar a o crescimento da cultura. O patê foi preparado com pescado cozido e cultura starter. Foram realizadas análises físico-químicas e microbiológicas do patê, que foram armazenados em embalagens de plástico e de vidro, durante 24 dias a 10°C. O patê apresentou conteúdos de umidade, cinzas, proteínas, lipídios e parâmetros de cor (próximo ao branco, vermelho e amarelo), estáveis durante estocagem e avaliação sanitária dentro dos padrões legais. O pH do produto diminuiu ao longo do tempo (de 6,43 para 5,11), enquanto as bases voláteis totais e a oxidação lipídica aumentaram (de 8,81 para 10,36 mgN/100g e de 0,35 para 0,52 MDA/Kg, respectivamente). As bactérias mesófilas aumentaram (de 6,66 para 9,25 log UFC/g), enquanto as bactérias psicrotróficas e Pseudomonas sp mostraram crescimento limitado (4,79 e 0 log UFC/g, respectivamente). As bactérias da cultura starter apresentaram um bom desenvolvimento (de 6,51 e 6,57 log UFC/g para 9,32 e 9,12 log UFC/g) e crescimento exponencial após uma curta fase de adaptação, conforme modelado pelo modelo de Gompertz. Baseando-se nesses resultados, o prazo comercial foi estabelecido em 15 dias, concluindo que desenvolver um patê de pescado adicionado de cultura starter proporcionará ao consumidor características atrativas.
Análise do perfil dos recém-nascidos com anóxia perinatal na Unidade de Terapia Intensiva Neonatal de uma maternidade privada em Sergipe
Authors: Matos Ana Caroline Gusmão de , Almeida Renata Carvalho , Andrade Thiago Vaz de , Pavione Marcos Alves 
Published: October 2023

Objetivo: Avaliar o perfil dos neonatos com idade gestacional ≥ 35 semanas com anóxia perinatal na Unidade de Terapia Intensiva Neonatal (UTIN) de uma maternidade privada de Aracaju, Sergipe. Metodologia: Trata-se de um estudo clínico observacional, de caráter descritivo e transversal. Utilizou-se amostra de conveniência, composta por todos os recém-nascidos com idade gestacional ≥ 35 semanas internados na UTIN de 01 janeiro de 2019 até 31 de dezembro de 2020. Foram excluídos os neonatos fora da idade gestacional do estudo e prontuários incompletos. O escore de Apgar menor que 7 no 5º minuto foi utilizado para definir anóxia neonatal (AN). A análise utilizou os testes Qui-Quadrado de Pearson, exato de Fisher, Shapiro-Wilk, Mann-Whitney e Kruskal-Wallis, além de dados descritivos. Aplicou-se nível de significância de 5%. Resultados: A amostra final foi de 127 crianças, majoritariamente do sexo masculino (63,7%), com peso normal ao nascer (75,2%) e peso adequado para idade gestacional (79,6%). O peso médio e idade gestacional média foram 2.982,7 gramas (± 649,5) e 37,5 semanas (± 1,6), respectivamente. Os grupos com e sem AN não apresentaram diferenças epidemiológicas significativas. Foi encontrado maior risco de anoxia em nascidos por via vaginal (p=0,001) e naqueles com eventos perinatais agudos (p=0,003). Tamanho pequeno para idade gestacional foi fator de risco para o desfecho óbito. Conclusão: Eventos perinatais agudos e parto vaginal são fatores de risco para AN. Recém-nascidos pequenos para idade gestacional apresentam piores desfechos. Futuros estudos discriminando os tipos de parto para análise de associação com AN podem ser úteis.
PENYULUHAN TENTANG KEBERSIHAN LINGKUNGAN WARGA MASYARAKAT TERHADAP MAHASISWA PPL IKIP BUDI UTOMO MALANG DALAM GOTONG ROYONG PEMBERSIHAN LINGKUNGAN DI AREA KANTOR DESA ANA GOKA.
Authors: Novariyanto Rizki Agung , Kondo Martina 
Published: October 2023

Kegiatan Pmbp ini berfokus pada peran mahasiswa PPL dalam melaksanakan kegiatan gotong royong. Peran mahasiswa PPL ini dalam melaksanakan kegiatan gotong royong sangat memungkinkan dan mengingat apa yang menjadi kewenangannya, tentunya dapat membangun kesadaran masyarakat desa. Oleh karena itu perlu suatu strategi maupun kebijakan agar dalam pelaksanaanya dapat berjalan dengan baik. Kegiatan PMBP ini bertujuan untuk mendeskripsikan serta peran masyarakat dalam melaksanakan kegiatan gotong royong di Desa Anagouka. Informan penelitian ini adalah kepala desa, Aparat desa, dan warga masyarakat di Desa Anagouka. Teknik pengumpulan data pada penelitian ini adalah observasi, gotong royong, dan dokumentasi. Hasil yang di dapatkan dalam penelitian ini menunjukkan beberapa hal pertama, melalui kegiatan gotong royong bersama aparat desa dan masyarakat desa mali iha, kepedulian masyarakat terhadap mahasiswa ppl dalam membantu melaksanakan kegiatan pmbp, aparatur desa sebagai motivator telah bekerjasama dalam hal ini bersama-sama meningkatkan pembangunan desa dengan pelaksanaan gotong royong, peran aparatur desa sebagai fasilitator cukup membantu masyarakat desa Ana goka, yang menyatakan bahwa kepala desa sangat membantu dalam memecahkan masalah pembangunan desa.
RODA DE CONVERSA COMO ESTRATÉGIA PARA APRENDER E FLORESCER COM A PESSOA IDOSA: ESTUDO DE CASO
Authors: Ratiguieri Gisele Maria , de Oliveira da Silva Souza Eliane , Ramos Costa Maria Antonia , Gomes Labegalini Célia Maria 
Published: October 2023

O estudo objetiva descrever uma estratégia de promoção da interação social de pessoas idosas participantes do Serviço de Convivência e Fortalecimento de Vínculos. Trata-se de um estudo de caso descritivo e exploratório desenvolvido com usuários idosos do Serviço de Convivência e Fortalecimento de Vínculos de um Centro de Referência da Assistência Social, localizado na cidade de Paranavaí, região noroeste do estado do Paraná. A promoção da interação social, cooperação e trabalho em equipe ocorreu por meio de atividades lúdicas que incentiva a igualdade, o pertencimento e a colaboração as quais, resultam em melhor qualidade de vida e fortalecimento das relações sociais. Para alcançar o desenvolvimento sustentável neste projeto, é necessário que a política pública adote abordagens inovadoras, investindo em recursos, sejam eles humanos ou equipamentos, a fim de promover a inclusão social e criar um mundo mais justo, onde as necessidades das pessoas sejam atendidas. Neste caso a necessidade de fortalecer vínculos comunitários e ampliar a rede de apoio se dá por meio do resgate à cultura de visitas aos domicílios de pessoas idosas, com vista a minimizar o isolamento social.
RANCANG BANGUN SISTEM INFORMASI MANAJEMEN INVENTARIS BERBASIS WEBSITE MENGGUNAKAN METODE SDLC
Authors: Nadhia Annisya Nadhia , Suwarno Suwarno 
Published: October 2023

Pemanfaatan sistem informasi telah memberikan dukungan bagi kegiatan operasional dalam menjalankan proses bisnis perusahaan secara cepat dan praktis. Sistem manajemen inventaris menjadi salah satu contoh penerapan sistem informasi dalam menyediakan kontribusi kepada perusahaan. PT.XYZ sebagai perusahaan sering menghadapi tantangan dalam manajemen inventaris. Pada penelitian ini, merancang suatu sistem manajemen inventaris yang dapat mengatasi kesulitan pengelolaan inventaris perusahaan. Sistem ini bertujuan untuk mengatasi permasalahan manajemen inventaris dengan pemantauan stok barang, pengecekan kerusakan dan perbaikan secara rinci, pelacakan penyimpanan dengan akurat, dan lainnya. Metode penelitian ini menggunakan metode System Development Life Cycle (SDLC) dengan model; prototype. Penelitian ini menghasilkan suatu sistem manajemen inventaris yang dapat mendata seluruh arus pengelolaan barang-barang inventaris menjadi lebih akurat, praktis, serta optimal.
Mid-T heat treatments on BCP’ed coaxial cavities at TRIUMF
Authors: Kolb P. , Yao Z. , Blackburn A. , Gregory R. , Hedji D. , McMullin M. , Junginger T. , Laxdal R. E. 
Published: October 2023

Mid-T heat treatments in the range from 250°C to 400°C on superconducting radio-frequency (SRF) cavities have been shown to provide high quality factors that rise with applied rf field strength in high frequency, electro-polished (EP), elliptical cavities operating at 2 K, similar to nitrogen doped cavities. The rise in quality factor is attributed to a decrease in the temperature dependent part of the surface resistance RBCS. Until now, no results have been reported for these new treatments on quarter-wave resonators (QWR) and half-wave resonators (HWR). The TRIUMF multi-mode coaxial cavities are dedicated test cavities that allow frequency and temperature resolved performance characterization of treatments without changing environments, therefore providing an excellent test vehicle to test these new treatments with rf frequencies ranging from 200 to 1,200 MHz. In this paper, performance measurements from both QWR and HWR cavities are reported and their performance compared with four different treatments: baseline, a conventional 120°C low temperature bake for 48 h, and two mid-T bakes at 300°C and 400°C for 3 h. In addition, sample analysis using SEM, EDX and SIMS of witness samples is also shown. It is found that the mid-T bakes are not directly transferable to low frequency cavities. In the fundamental modes of the two test cavities, no performance gain over the baseline treatment nor a decreasing temperature dependent component with rising rf amplitude was observed. At frequencies above 1 GHz and low temperatures, the mid-T bakes show a reduced field dependence of RBCS compared to both the baseline and 120°C treatments.
Exercise sensitizes PD-1/PD-L1 immunotherapy as a hypoxia modulator in the tumor microenvironment of melanoma
Authors: Yan Huiyu , Jiang Aimin , Huang Yinong , Zhang Jun , Yang Wenguang , Zhang Wei , Liu Tianya 
Published: October 2023

IntroductionHypoxia is associated with unfavorable prognoses in melanoma patients, and the limited response rates of patients to PD-1/PD-L1 blockade could be attributed to the immunosuppressive tumor microenvironment induced by hypoxia. Exercise offers numerous benefits in the anti-tumor process and has the potential to alleviate hypoxia; however, the precise mechanisms through which it exerts its anti-tumor effects remain unclear, and the presence of synergistic effects with PD-1/PD-L1 immunotherapy is yet to be definitively established.MethodsWe established a B16F10 homograft malignant melanoma model and implemented two distinct exercise treatments (low/moderate-intensity swim) based on the mice’s exercise status. The specific function manner of exercise-induced anti-tumor effects was determined through RNA sequencing and analysis of changes in the tumor microenvironment. Furthermore, moderate-intensity swim that exhibited superior tumor suppression effects was combined with Anti-PD-1 treatment to evaluate its in vivo efficacy in mouse models.ResultsExercise intervention yielded a considerable effect in impeding tumor growth and promoting apoptosis. Immunohistochemistry and RNA sequencing revealed improvements in tumor hypoxia and down-regulation of hypoxia-related pathways. Cellular immunofluorescence and ELISA analyses demonstrated a notable increase of cytotoxic T cell amount and a decrease of regulatory T cells, indicating an improvement of tumor immune microenvironment. In comparison to Anti-PD-1 monotherapy, tumor suppressive efficacy of exercise combination therapy was found to be enhanced with improvements in both the hypoxic tumor microenvironment and T cell infiltration.ConclusionExercise has the potential to function as a hypoxia modulator improving the tumor immune microenvironment, resulting in the promotion of anti-tumor efficacy and the facilitation of biologically safe sensitization of PD-1/PD-L1 immunotherapy.
Effect of tofacitinib therapy on angiotensin converting enzyme activity in rheumatoid arthritis
Authors: Kacsándi Dorottya , Fagyas Miklós , Horváth Ágnes , Végh Edit , Pusztai Anita , Czókolyová Monika , Soós Boglárka , Szabó Attila Ádám , Hamar Attila , Pethő Zsófia , Bodnár Nóra , Kerekes György , Hodosi Katalin , Szamosi Szilvia , Szűcs Gabriella , Papp Zoltán , Szekanecz Zoltán 
Published: October 2023

IntroductionThe Renin-Angiotensin-Aldosterone system (RAAS) has been implicated in the regulation of the cardiovascular system and linked to rheumatoid arthritis (RA). Little information has become available on the effects of Janus kinase (JAK) inhibition on RAAS. Here we studied the effects of 12-month tofacitinib treatment on angiotensin converting enzyme (ACE), ACE2 production and ACE/ACE2 ratios in RA along with numerous other biomarkers.Patients and methodsThirty RA patients were treated with tofacitinib in this prospective study. Serum ACE concentrations were assessed by ELISA. ACE2 activity was determined by a specific quenched fluorescent substrate. ACE/ACE2 ratios were calculated. We also determined common carotid intima-media thickness (ccIMT), brachial artery flow-mediated vasodilation (FMD) and carotid-femoral pulse-wave velocity (cfPWV) by ultrasound. C-reactive protein (CRP), rheumatoid factor (RF) and anti-citrullinated protein autoantibodies (ACPA) were also determined. All measurements were performed at baseline, as well as after 6 and 12 months of tofacitinib treatment.ResultsAfter the dropout of 4 patients, 26 completed the study. Tofacitinib treatment increased ACE levels after 6 and 12 months, while ACE2 activity only transiently increased at 6 months. The ACE/ACE2 ratio increased after 1 year of therapy (p &lt; 0.05). Logistic regression analyses identified correlations between ACE, ACE2 or ACE/ACE2 ratios and RF at various time points. Baseline disease duration also correlated with erythrocyte sedimentation rate (ESR) (p &lt; 0.05). One-year changes of ACE or ACE2 were determined by tofacitinib treatment plus ACPA or RF, respectively (p &lt; 0.05).ConclusionJAK inhibition increases serum ACE and ACE/ACE2 ratio in RA. Baseline inflammation (ESR), disease duration and ACPA, as well as RF levels at various time points can be coupled to the regulation of ACE/ACE2 ratio. The effect of tofacitinib on RAAS provides a plausible explanation for the cardiovascular effects of JAK inhibition in RA.
Predictive risk factors before the onset of familial rheumatoid arthritis: the Tatarstan cohort study
Authors: Arleevskaya Marina I. , Larionova Regina V. , Shagimardanova Elena I. , Gogoleva Natalia E. , Kravtsova Olga A. , Novikov Andrej A. , Kazarian Gevorg G. , Carlé Caroline , Renaudineau Yves 
Published: October 2023

BackgroundA familial history of rheumatoid arthritis (RA) predisposes an individual to develop RA. This study aimed at investigating factors associated with this conversion from the Tatarstan cohort.MethodsA total of 144 individuals, referred to as pre-RA and at risk for familial RA, were selected 2 years (range: 2–21 years) before conversion to RA and compared to non-converted 328 first-degree relatives (FDR) from RA as assessed after ≥2 years follow-up, and 355 healthy controls were also selected (HC). Preclinical parameters and socio-demographic/individual/HLA genetic factors were analyzed when data were available at the time of enrollment.ResultsAs compared to FDR and HC groups, pre-RA individuals were characterized before conversion to RA by the presence of arthralgia, severe morning symptoms, a lower educational level, and rural location. An association with the HLA-DRB1 SE risk factor was also retrieved with symmetrical arthralgia and passive smoking. On the contrary, alcohol consumption and childlessness in women were protective and associated with the HLA-DRB1*07:01 locus.ConclusionBefore RA onset, a combination of individual and genetic factors characterized those who are at risk of progressing to RA among those with familial RA relatives.