bluuebunny/crossref_metadata_2025_split huggingface dataset:
PENGEMBANGAN SISTEM INFORMASI MANAJEMEN OBJEK WISATA RINTISAN BERBASIS PLATFORM MENGGUNAKAN FRAMEWORK PHP
Authors: Shihab Farrel Muhammad , Persada Andhika Giri 
Published: October 2023

Objek wisata merupakan hal yang disukai dan dituju sebagai destinasi utamanya ketika akhir pekan tiba,hal ini dibuktikan melalui data statistik berbagai tempat wisata yang mengalami kenaikan fluktuatif ketika menjelang akhir pekan atau hari libur.Peningkatan kunjungan wisata diberbagai tempat ketika akhir pekan atau hari libur menunjukan bahwa antusias masyarakat dalam berwisata cukup tinggi.
Antusias masyarakat yang cukup tinggi dalam berwisata,mendorong sebagian masyarakat kreatif di berbagai wilayah untuk mengembangkan wisata baru agar masyarakat memiliki pengalaman baru terhadap destinasi wisata.Peningkatan objek wisata rintisan disinggung pada acara Rapat Koordinasi Destinasi Super Prioritas Borobudur 2020.
Pengoptimalan pengunjung atau wisatawan ditempat wisata rintisan perlu dilakukan.Pengoptimalan dilakukan melalui promosi di media internet.Media internet diakses secara luas oleh publik,media internet dapat berupa media sosial,apps platform,dan website.
Penelitian dilakukan bertujuan untuk pengembangan dan pemanfaatan teknologi informasi dibidang pariwisata melalui sistem informasi manajemen objek wisata rintisan.
Pengembangan Sistem Informasi Manajemen Objek Wisata Rintisan dilakukan melalui metode UCD atau User Centered Design.
Tahap pengembangan dilalui dari beberapa proses yang diawali identifikasi masalah.Identifikasi masalah didapat melalui observasi wawancara ditempat penelitian yaitu beberapa objek wisata rintisan di Yogyakarta dan Jawa Tengah.Dari hasil observasi yang didapat selanjutnya mengekstraksi informasi-informasi sebagai daftar kebutuhan yang disebut analisis kebutuhan pengguna.Analisis kebutuhan pengguna yang telah disusun kemudian dilakukan perancangan sistem.Perancangan sistem dilakukan untuk menghasilkan mock-up yang sesuai atas kebutuhan pengguna.Perancangan sistem dibagi melalui beberapa fitur-fitur yang didapat dari analisis kebutuhan.selanjutnya dilakukan implementasi rancangan sistem sehingga sistem dapat digunakan oleh pengguna sesuai fungsional.Tahap terakhir yaitu evaluasi untuk menghasilkan improvisasi sistem.
Dari penelitian dan pengembangan diperoleh analisis kebutuhan yang sesuai dalam bentuk fitur-fitur sistem,hasil prototype antarmuka dan user experience,desain basisdata,dan hasil baku sistem informasi manajemen objek wisata rintisan.
A programmable CRISPR-based light-up RNA stabilizer for fluorogenic RNA imaging
Authors: Fan Ze , Liu Fei , Wang Fenglin , Chu Xia , Jiang Jian-Hui 
Published: October 2023

Abstract
Live cell imaging of RNAs and dynamics is crucial for understanding their functions and pathological roles. However, fluorogenic imaging of endogenous RNAs remains a challenge. Here, we report the design of a programmable CRISPR-based light-up RNA stabilizer (LUSTER) that enables fluorogenic imaging of endogenous RNAs without the need for genetically inserted tags. We show that dCas9 can bind and stabilize the otherwise degraded guide RNAs (gRNAs). A light-up aptamer-embedded, mis-folded gRNA is designed to restore the dCas9-binding conformation in response to target RNAs and to provide fluorogenic signals from the dCas9-stabilized gRNA for RNA imaging. Our system is universally applicable for quantitative detection and dynamic imaging of diverse RNA targets, including mRNA detection, single-molecule and multiplexed RNA imaging, cytosolic or nuclear RNA localization imaging, and RNA-induced orthogonal transcriptional activation in mammalian cells. The programmability and general applicability of the LUSTER system highlight its broad utility in RNA biology and theranostics.
Mental health and cognitive outcomes in patients six months after testing positive compared with matched patients testing negative for COVID-19 in a non-hospitalized sample: A retrospective cohort study
Authors: Ward Brooklyn , Edgar Nicole E. , Ahluwalia Chloe , Huang Eileen , Corsi Daniel , Cameron D William J , Colman Ian , Kaluzienski Mark , Orpana Heather , MacLean Sarah E , Hatcher Simon 
Published: October 2023

Abstract
Objectives: We aimed to determine the mental health and cognitive outcomes at six months of people who had not been hospitalized with COVID-19 and who had tested positive or negative for COVID-19 in Eastern Ontario.

Methods: Participants were matched 1:1 six months following their COVID-19 polymerase chain reaction test. Primary analyses compared COVID-positive with matched COVID-negative participants. In addition, within the COVID-19 positive population, we used an age and gender-adjusted logistic regression analysis to explore risk factors associated with depression, anxiety, and cognitive impairment.

Results: 324 participants were enrolled (n=162 per arm). 40.7% of those in the COVID-positive group were men, with an average age of 37.9 (SD 13.2) years. In the COVID-negative group 41.4% were men, with an average age of 36.7 (SD 12.8). There were no statistically significant differences in mental health outcomes between the two groups. On cognitive testing, while 21% of the COVID-positive participants and 14% of the COVID-negative participants had scores indicating significant cognitive impairment, the difference between the two groups was not significant. Risk factors for poor mental and cognitive outcomes differed between the two groups.

Conclusion: In non-hospitalized patients who have tested positive for COVID-19, there is no evidence of an increase in mental health disorders compared to people who tested negative. Any increases in mental health disorders during the pandemic may be the effect of social changes rather than an effect of the virus itself. The exception may be the cognitive changes in those who tested positive.
Outcomes Of Women with Preeclampsia and Eclampsia Admitted in The Intensive Care Unit at A Tertiary Care Hospital in Mogadishu, Somalia.
Authors: Hilowle Nasra Mohamud , Ahmed Said Abdirahman , Ali Khadija Yusuf , Köprülü Diyar , Waberi Mohamud Mire , Hassan Mohamed Sheikh , Altinel Ercan , Hassan Mohamed Omar 
Published: October 2023

Abstract
Intensive care for a hypertensive mother with pre-eclampsia or eclampsia is crucial for both maternal and neonatal outcomes. This study highlights the level of morbidity and mortality among women with preeclampsia and eclampsia admitted to the intensive care unit.
Methods: This retrospective study was conducted in Mogadishu, Somalia, at the Mogadishu Somali Türkiye Training and Research Hospital fromFebruary 2019 to July 2022. The study focused on the different complications, managements, and final outcomes of preeclampsia and eclampsia mothers admitted to the intensive care unit. The data was retrieved from the electronic records of patients admitted to the intensive care unit.
Results: During our study period, a total of 237 patients were identified as having preeclampsia/eclampsia, of whom 71 required intensive care admission. The mean age of the studied patients was 25±6years. The most common reason for being taken to the intensive care unit (ICU) was having a seizure (n = 33, 46.5%), followed by having very high blood pressure (n = 20, 28.2%), and being confused (n = 18, 25.3%). Peripartum infection was the most common maternal complication during ICU admission (66.7%), followed by cardiac-related arrhythmia (66.7%), postpartum bleeding (48%), acute kidney injury (18.4%), HELLP syndrome (16.4%), severe anemia (9.6%), and stroke (8.7%). Among patients, 65 (91.5%) needed mechanical ventilation. About 11.1% of these patients died during hospitalization. There were associations between mortality and some complications, particularly acute kidney injury (p-value less than 0.02) and peripartum infection (p-value less than 0.003).
Conclusion:
Hypertensive disease of pregnancy (preeclampsia/eclampsia) requiring intensive care unit admission has a very high morbidity and mortality rate.
Comparative analysis of SIMILAR TO RCD ONE (SRO) family from tetraploid and diploid cottons depicts its role in growth and development
Authors: SHABAN Muhammad , TABASSUM Riaz , RANA Iqrar Ahmad , ATif Rana Muhammad , AZMAT Muhammad Abubakkar , Iqbal Zubair , Azhar Muhammad Tehseen 
Published: October 2023

Abstract
Background
SRO (Similar to RCD1) genes family is largely recognized for their importance in growth, development and in responding to environmental stresses. However, genome-wide identification and functional characterization of SRO genes from cotton species have not reported so far.
Results
A total of 36 SRO genes were identified from four cotton species. Phylogenetic analysis divided these genes into three groups with distinct structure. Syntenic and chromosomal distribution analysis indicated uneven distribution of GaSRO, GrSRO, GhSRO and GbSRO genes on A2, D5 genomes, Gh-At, Gh-Dt and Gb-At, Gb-Dt subgenomes, respectively. Gene duplication analysis revealed the presence of six duplicated gene pairs among GhSRO genes. In promoter analysis, several elements responsive to growth, development and hormones were interpreted in GhSRO genes, implying the reason for their induction during growth and developmental stages. Several miRNAs responsive to plant growth and abiotic stress responses were predicted that target 12 GhSRO genes. Organ-specific expression profiling explored the roles of GhSRO genes in one or more tissues. In addition, specific expression pattern of some GhSRO genes during ovule developmental stages depicted their involvement in these developmental processes.
Conclusion
The data presented in this report laid a foundation for understanding the classification and functions of SRO genes in cotton.
The fate of salp blooms: decomposition and sinking of salp carcasses
Authors: Orlov Polina , Pakhomov Evgeny 
Published: October 2023

Abstract

Gelatinous zooplankton (GZ) biomass is an important, yet often overlooked, vector of the particulate organic matter downward export and a nutritional prey source for the mesopelagic and benthic communities. To better quantify the potential impact of their blooms on biogeochemistry and food webs, we performed decomposition and sinking experiments under two different temperature regimes, 6 and 12 °C using 260 Salpa aspera, sampled in the Northeast Pacific (48.39°-50.40°N, 126.40°-145.00°W) during May 2021. Salp decay was exponential and occurred ~1.5 times faster under warmer conditions. Comparison of the published GZ decay rates supported their strong temperature dependence (Q10 = 3.46) and revealed that S. aspera decayed slower than most GZ taxa. Carcass sinking rates were higher than previously reported for this species and slowed after a prolonged decay. Biochemical (proteins, carbohydrates, lipids) and elemental (C: carbon, N: nitrogen) compositions were determined for salps at various decomposition stages. The high water content (~97%) and low organic content (27.8 ± 7.1 % dry weight) was typical of other thaliaceans. The high C:N ratio (6.61 ± 1.14) of S. aspera, compared to many thaliaceans, suggested that their carcasses are valuable sources of carbon beyond the euphotic zone.
Transovarial transmission of Yersinia pestis in its flea vector, Xenopsylla cheopis
Authors: Pauling Cassandra D. , Beerntsen Brenda T. , Song Qisheng , Anderson Deborah M. 
Published: October 2023

Abstract

Yersinia pestis is the causative agent of bubonic plague, a deadly flea-borne disease responsible for three historic pandemics. Today annual cases of human disease occur worldwide following exposure to Y. pestis infected fleas that can be found within the rodent population where plague activity cycles between epizootic outbreaks and extended periods of apparent quiescence. Flea transmission of Y. pestis is most efficient in “blocked” fleas that are unable to feed, whereas mammalian transmission to fleas requires a susceptible host with end-stage high titer bacteremia. These facts suggest alternative mechanisms of transmission must exist to support the persistence of Y. pestis between epizootic outbreaks. In this work, we addressed whether vertical transmission could be a mechanism for persistent low-infection across generations of fleas. We demonstrate that Y. pestis infection of the Oriental rat flea, Xenopyslla cheopis, spreads to the reproductive tissues and is found in eggs produced by infected adult fleas. We further show that vertical transmission of Y. pestis from eggs to adults results in midgut colonization indicating a strong probability that it can reenter the sylvatic plague cycle.
Supporting Physical Activity for Mobility in Older Adults with Mobility Limitations (SuPA Mobility): Study Protocol for a Randomized Controlled Trial
Authors: Rice Jordyn , Li Linda C. , Davis Jennifer C. , Pahor Marco , Madden Kenneth , Wei Nathan , Wong Hubert , Skelton Dawn A. , McCormick Sioban , Falck Ryan S. , Barha Cindy K. , Rhodes Ryan E. , Loomba Sohail , Sadatsafavi Mohsen , Liu-Ambrose Teresa 
Published: October 2023

Abstract
Background:
Limited mobility in older adults consistently predicts both morbidity and mortality. As individuals age, the rates of mobility disability increase from 1.0% in people aged 15–24 to 20.6% in adults over 65 years of age. Physical activity can effectively improve mobility in older adults, yet many older adults do not engage in sufficient physical activity. Evidence shows that increasing physical activity by 50 minutes of moderate intensity physical activity in sedentary older adults with mobility limitations can improve mobility and reduce the incidence of mobility disability. To maximize the healthy life span of older adults, it is necessary to find effective and efficient interventions that can be delivered widely to prevent mobility limitations, increase physical activity participation, and improve quality of life in older adults. We propose a randomized controlled trial to assess the effect of a physical activity health coaching intervention on mobility in older adults with mobility limitations.
Methods:
This randomized controlled trial among 290 (145 per group) community-dwelling older adults with mobility limitations, aged 70–89 years old, will compare the effect of a physical activity health coaching intervention versus a general healthy aging education program on mobility, as assessed with the Short Physical Performance Battery. The physical activity health coaching intervention will be delivered by exercise individuals who are trained in Brief Action Planning. The coaches will use evidence-based behavior change techniques including goal-setting, action planning, self-monitoring, and feedback to improve participation in physical activity by a known dose of 50 minutes per week. There will be a total of 9 health coaching or education sessions delivered over 26-weeks with a subsequent 26-week follow-up period, wherein both groups will receive the same duration and frequency of study visits and activities.
Discussion:
The consequences of limited mobility pose a significant burden on the quality of life of older adults. Our trial is novel in that it investigates implementing a dose of physical activity that is known to improve mobility in older adults utilizing a health coaching intervention.
Trial registration:
ClinicalTrials.gov Protocol Registration System: NCT05978336; Registered on 28 July 2023.
Ultra-Stretchable, Crack Propagation Resistance and Impact-Resistant Ionogels
Authors: Tian Lei , Huang Haiyu , Wuliu Yishun , Dong Weiliang , Tan Jiji , Xu Yongbin , Zhu Caizhen , Xu Jian 
Published: October 2023

Abstract
Ionogels equipped with high ionic conductivity, excellent thermal/chemical/electrochemical stability and flexibility, have been considered an ideal candidate for hydrogels. However, the long-term reliability against fatigue and impact resistance of the ionogels remain crucial challenges that hinder their practical application and have yet to be addressed by effective strategies. Herein, a multiple non-covalent interactions strategy inspired by the human skin have been proposed to realize the synergistic effect of physical entanglement and microphase separation. Moreover, the introduction of collagen, a biomacromolecule, creates cohesion of the microphase and multiple hydrogen bonds. Thus fabricated ionogels are perfectly endowed with unprecedented ultra-stretchability (> 50,000%) and ultra-high toughness (43 MJ m-3). It can stably maintain 300 times its own volume expansion and resist puncture by sharp objects. Furthermore, the ionogels have overcome the bottleneck problems of crack propagation resistance and impact resistance that have plagued their development. We can predict that our proposed construction strategy will provide theoretical and experimental accumulation for the practical and extensive development of ionogels.
Designing community-level integral interventions for active ageing: a systematic review from the lens of community-based participatory research
Authors: Wang Gubing , Chang Fangyuan , Gu Zhenyu , Kasraian Dena , Wesemael Pieter J. V. 
Published: October 2023

Abstract
Background: While community-level interventions for promoting active ageing have received growing attention and there is a trend to leverage technology to support traditional physical or social interventions, little hands-on guidance exists for designing these interventions.
Methods: The literature review focused on community-level interventions promoting active ageing that integrated physical, social, and digital elements, referred to as integral interventions. Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) guidelines were followed. In addition, as Community-Based Participatory Research (CBPR) principles have been widely applied for co-designing with the community on interventions that address complex health and social problems, the included interventions were analysedabductively based on the CBPR principles.
Results:Twenty-four design considerations were generated under eight categories. Further reflection identified the interrelated nature of these design considerations and pinpointed the gaps in current research. The study highlights the urgency and importance of sharing recruitment methods and resource allocation details, recording and reporting collaboration specifics, clarifying stakeholder representation, fostering co-learning between communities, adopting an incremental approach, promoting inclusivity, and disseminating findings to stakeholders beyond academia.
Conclusions: This study offers valuable insights and practical guidance to researchers and practitioners engaged in developing community-level integral interventions for active ageing. The findings also serve as a starting point for accumulating knowledge and practice in co-designing integral interventions for active ageing at the community level. The next crucial phase involves evaluating these design considerations within a real-world case to assess their applicability and identify potential areas for improvement.
Higher-order Response Surface Method-based Optimization of Centrifugal Impeller of Combined Fuel Pump
Authors: Liu Xianwei , Zhong Shijie , Fu Jiangfeng , Xu Siyuan , Zhou Zhenhua 
Published: October 2023

Abstract
A centrifugal-gear combined fuel pump is a new type of engine fuel pump, and the performance of the centrifugal stage is crucial for the reliable operation of the combined fuel pump. This paper presents a multi-objective optimization of the centrifugal impeller of a combined fuel pump using the higher-order response surface method and NSGA-II algorithm. First, a turbulence model used in numerical simulation is validated and established through a combination of physical test and simulation calculation. Second, the complexity of design parameters is reduced by the significance analysis of full factorial screening model, and the surrogate model of efficiency and head of centrifugal stage of combined fuel pump is constructed using Latin hypercube sampling and high-order response surface method. Finally, multi-objective optimization is performed via NSGA-II algorithm, and the optimization results are validated by numerical simulation. The research findings show that the blade angle at leading edge, blade angle at trailing edge and wrap angle determined by the significance analysis of the full factorial screening model have a significant influence on the efficiency response value and are therefore the key sensitive parameters for optimization. The surrogate model of head and efficiency constructed based on higher-order response surface method demonstrates high calculation accuracy, with sample standard deviations of 0.132 and 0.189 respectively. At the design point, the head and efficiency of the optimized centrifugal stage of the pump are increased by 2.25% and 2.54% respectively, and the internal flow becomes more even, and the adverse flow is significantly alleviated.
Exosomal miR-17-5p derived from epithelial cells is involved in aberrant epithelium-fibroblast cross-talk and induces the development of oral submucosal fibrosis
Authors: Tao Yongguang , Xie Changqing , Zhong Liang , Feng Hui , Wang Rifu , Shi Yuxin , Lv Yonglin , Hu Yanjia , Li Jing , Xiao Desheng , Liu Shuang , Chen Qianming 
Published: October 2023

Abstract

Oral submucous fibrosis (OSF) is a chronic and inflammatory mucosal disease caused by betel quid chewing, which is an oral potential malignant disorder. The abnormal differentiation of fibroblasts leading to collagen metabolism disorder is the core process of OSF development. As the first line of defense against the external environment, epithelium can convert external signals into pathological signals and participate in the remodeling of fibrotic microenvironment. However, the specific mechanisms underlying epithelium drives fibroblast differentiation remains unclear. In this study, we found that arecoline exposed epithelium communicated with the fibrosis microenvironment by secreting exosomes. MiR-17-5p was enclosed in epithelial-derived exosomes and absorbed by fibroblasts, promoting cell secretion, contraction, migration and fibrogenic marker expression (α-SMA and collagen I). Underlying molecular mechanism was miR-17-5p targeting Smad7, thus promoting the degradation of the Smad7 through the ubiquitin-proteasome pathway and amplifying the classical TGF-β fibrotic pathway. Targeting miR-17-5p with its inhibitor to treat fibroblasts can restore the cell contraction and migration phenotype induced by epithelial-derived exosomes. It was confirming that exosomal miR-17-5p can act as a key regulator of phenotypic transformation of fibroblasts. In conclusion, we demonstrate that arecoline triggers aberrant epithelium-fibroblast cross-talk and identify miR-17-5p derived from epithelial cells as a mediator of fibroblast differentiation through the classical TGF-β fibrotic pathway, which provided a new perspective and strategy for diagnosis and treatment of OSF.