bluuebunny/crossref_metadata_2025_split huggingface dataset:
Genomic and biological variation in bat IFNs: An antiviral treatment approach
Authors: AL‐Eitan Laith , Mihyar Ahmad , Zhang Liguo , Bisht Punam , Jaenisch Rudolf 
Published: November 2023

AbstractBat‐borne viruses have attracted considerable research, especially in relation to the Covid‐19 pandemic. Although bats can carry multiple zoonotic viruses that are lethal to many mammalian species, they appear to be asymptomatic to viral infection despite the high viral loads contained in their bodies. There are several differences between bats and other mammals. One of the major differences between bats and other mammals is the bats' ability to fly, which is believed to have induced evolutionary changes. It may have also favoured them as suitable hosts for viruses. This is related to their tolerance to viral infection. Innate immunity is the first line of defence against viral infection, but bats have metamorphosed the type of responses induced by innate immunity factors such as interferons. The expression patterns of interferons differ, as do those of interferon‐related genes such as interferon regulatory factors and interferon‐stimulated genes that contribute to the antiviral response of infected cells. In addition, the signalling pathways related to viral infection and immune responses have been subject to evolutionary changes, including mutations compared to their homologues in other mammals and gene selection. This article discusses the differences in the interferon‐mediated antiviral response in bats compared to that of other mammals and how these differences are correlated to viral tolerance in bats. The effect of bat interferons related genes on human antiviral response against bat‐borne viruses is also discussed.
Advanced Light: Liquid Crystals‐Based Ultra‐Broadband Polarization Rotator for Functional Smart Devices
Authors: Lee Jae‐Hwan , Ma Jun‐Seok , An Chan‐Heon , Lee Gi‐Ho , Oh Seung‐Won 
Published: November 2023

AbstractA novel ultra‐broadband polarization rotator with advanced angular adjustability is proposed for functional devices such as displays and smart windows. The new solution offers dynamic control of light polarization across a broad range of wavelengths, encompassing the complete visible spectrum, ultraviolet and near‐infrared. Moreover, it boasts a smaller footprint, faster response times, and lower dispersion compared to conventional rotators. The findings are remarkable in that they show that as the viewing angle increases, the hybrid alignment takes on a twist‐like configuration, with the polarization rotation angle determined by the spatial variation in the twist angle. This intriguing behavior leads to an improved range of angular adjustability, as the effective polarization rotation depth is extended. The improved angular adjustability of reconfigurable smart devices surpasses the limitations of traditional polarization rotators, unlocking new innovative possibilities. For example, the rotator plays a crucial role in display technologies, allowing for effective control of viewing angles and minimizing reflection from disturbing external light. Similarly, in smart windows, it optimizes energy conservation by regulating direct sunlight transmission while ensuring clear visibility in normal conditions. It is believed that the proposed advanced ultra‐broadband polarization rotator is a significant step forward in the development of reconfigurable smart devices.
Organisational ambidexterity and knowledge management: A systems perspective towards Smart Model‐based Governance
Authors: Armenia Stefano , Barile Sergio , Iandolo Francesca , Pompei Alessandro , Sicca Luigi Maria 
Published: November 2023

AbstractThe purpose of this paper is to propose a new framework for the governance of ‘modern’ smart organisations that integrates IT‐based orientation to decision‐making, systems thinking through system dynamics modelling and cybernetics. The design of the proposed framework is based on the key role played by knowledge in the governance of organisations. The literature on ambidexterity, organisational learning, knowledge management and systems thinking is the adopted research background. A synthesis of the connection points between these fields is proposed within a theoretical framework named Smart Model‐based Organisations. The main result of this work is represented by the proposed Smart Model‐based Governance (SMbG) framework and an example of application. There are two main findings related to the contribution of the proposed framework: the overcoming of ‘data‐based’ approaches that favour rigidity in knowledge governance and the contribution of systems approaches that, increasing organisational involvement, improve knowledge governance.
Reach-scale associations between introduced Brook Trout and juvenile and stream-resident Bull Trout in Idaho
Authors: Voss Nicholas S. , Bowersox Brett J. , Quist Michael C. 
Published: November 2023

Abstract

Objective
Native Bull Trout Salvelinus confluentus populations can be influenced by a variety of stressors operating at multiple spatial scales, making the relative importance of biotic versus abiotic controls difficult to discern at small scales where monitoring and management typically occur. Nonnative Brook Trout S. fontinalis were widely introduced throughout western North America and negatively affect Bull Trout occurrence. Here, we examine reach-scale associations between nonnative Brook Trout and juvenile and stream-resident Bull Trout (i.e., &lt;250 mm) abundances through the lens of a constraining threshold, where nonnative fish exceeding a certain fish density may constrain native fish abundance.

Methods
We used a large spatial data set to define the abiotic conditions in which stream-dwelling Brook Trout and Bull Trout smaller than 250 mm typically co-occur in Idaho. Next, we queried multipass electrofishing survey data collected in reaches with abiotic conditions suitable for both species within localized areas where their distributions overlap. We then used two-dimensional Kolmogorov–Smirnov tests to identify threshold Brook Trout densities beyond which Bull Trout less than 250 mm were consistently rare or absent.

Result
Bull Trout smaller than 250 mm were rare or absent where Brook Trout density exceeded 0.54 fish/100 m2 across the full range of abiotic conditions over which both species overlapped. However, Brook Trout rarely occurred in habitats associated with high Bull Trout density (e.g., where mean August water temperatures were 8.2°C).

Conclusion
Our results support existing hypotheses that the long-term co-occurrence of Bull Trout and Brook Trout in stream reaches suitable for both species may be unstable. Because low densities of Brook Trout appear to threaten Bull Trout, additional research is needed to better understand factors driving ongoing range shifts and invasion dynamics in Bull Trout habitat. We provide a simple tool to inform where Brook Trout represent a primary threat to Bull Trout, with potential applications for future monitoring, threat assessments, and conservation efforts.
Elemental composition of green tea infusions depending on the method of their brewing
Authors: Długaszek Maria , Mierczyk Jadwiga 
Published: November 2023

AbstractGreen tea infusions are a source of many bioactive compounds as well as elements, both nutrients and toxic ones. In this study, we assessed the content of elements in green tea infusions depending on the brewing time and their pH values. In instrumental analysis we used atomic absorption spectrometry. Elements such as Ca (calcium), Cu (copper), K (potassium), Mg (magnesium), Na (sodium), Fe (iron), Mn (manganese), Zn (zinc), and toxic Al (aluminium) were quantified in green tea infusions with pH = 6 and pH = 2, and after infusion times of 5, 10, and 20 min. The mean value of the elements in 250 mL of beverage was the following: (mg) K—114.68 ± 33.27, Ca—18.48 ± 334.24, Na—4.00 ± 0.92, Mg—2.71 ± 0.65, and (µg) Al 1266.53 ± 0.56, Mn—488.19 ± 320.46, Zn—46.65 ± 5.18, Fe—34.30 ± 10.96, Cu—5.00 ± 0.01. From 1 g of raw material, the following amounts of elements were leaching, µg/g: Al—ND-1479.89, Ca—190.42–7650.09, Fe—9.52–42.30, K—42108.07–108337.90, Mg—661.14–1760.73, Mn—58.82–931.19, Na—ND-1959.09, Zn—2.50–16.83. Cu content was at the LOD of the method. Based on the statistical analyses, significant differences between the sample series were found. Al and Mn significantly positively correlated with most of the elements studied. Both pH and brewing times affected the amount of extracted elements, especially in the case of Al, Ca, and Mn. The amount of K did not change much during the preparation of the brews. The acidic environment allows a large amount of leaching of Al and Mn into the infusion.
The combination of brentuximab vedotin and chidamide synergistically suppresses the proliferation of T-cell lymphoma cells through the enhancement of apoptosis
Authors: Tonozuka Yukio , Tanaka Hiroshi , Nomura Kazumi , Sakaguchi Kazuya , Soeda Junpei , Kakimoto Yoshihide 
Published: November 2023

Abstract
Purpose
Peripheral T-cell lymphoma (PTCL) is an aggressive disease with a poor prognosis. Brentuximab vedotin (BV), an anti-CD30 monoclonal antibody linked to a microtubule-disrupting agent, has been approved for the treatment of PTCL. We evaluated a new effective combination partner of BV using non-clinical approaches that could potentially identify agents capable of improving survival times for patients with PTCL.

Methods
A high-throughput screening test was used to select the most synergistic partner of BV from 14 candidate drugs that were under development or available in clinical practice for PTCL. HH cells, originating from an aggressive cutaneous T-cell lymphoma, were used as an experimental model of PTCL. Apoptotic effects of the synergistic partner of BV were further investigated in vitro and in vivo using HH-cell xenograft mice.

Results
Chidamide (tucidinostat), a novel histone deacetylase inhibitor, was found to have the greatest synergistic effect with BV on HH cells. The combined effects of chidamide and BV were demonstrated in a study of HH-cell xenograft mice; mean tumor size following combined treatment was 22% of that observed in the control group, compared with 71% and 58% following chidamide and BV monotherapy, respectively. Further investigations in vitro and in vivo revealed that the levels of an anti-apoptotic protein, Bcl-2, and a rate-limiting factor of DNA replication, CDC45, were reduced in HH cells treated with chidamide combined with BV compared with the control group.

Conclusion
The use of chidamide in conjunction with BV may positively affect and enhance T-cellular apoptotic pathways without offsetting each other.
One-point quadrature of higher-order finite and virtual elements in nonlinear analysis
Authors: Bode Tobias 
Published: November 2023

AbstractIn the present article, a stability- and consistency-preserving integration scheme for polynomial Galerkin approaches of arbitrary order is presented. The basis is formed by Taylor series expansions of the stresses with respect to the strains, which in turn are expanded towards the spatial directions. With a split of the material and geometric nonlinearities and the assumption of a material behavior linearly variable within an element, the strain energy in elements of arbitrary shape and polynomial order can be evaluated exactly. Therefore, geometric moments have to be calculated in preprocessing, requiring only evaluations of derivatives at a single integration point during the analysis. The moments can be effectively integrated analytically over the boundary of the elements. As one of the manifold applications, the use in the context of second order virtual elements is elaborated for which the assembly time can be significantly reduced. The combination with the automatic differentiation and expression optimization software AceGen provides performant element routines. In the numerical examples, the integration scheme shows promising accuracy and makes the application in more complex material models up to computational homogenization attractive.
Conflict-based negotiation strategy for human-agent negotiation
Authors: Keskin Mehmet Onur , Buzcu Berk , Aydoğan Reyhan 
Published: November 2023

AbstractDay by day, human-agent negotiation becomes more and more vital to reach a socially beneficial agreement when stakeholders need to make a joint decision together. Developing agents who understand not only human preferences but also attitudes is a significant prerequisite for this kind of interaction. Studies on opponent modeling are predominantly based on automated negotiation and may yield good predictions after exchanging hundreds of offers. However, this is not the case in human-agent negotiation in which the total number of rounds does not usually exceed tens. For this reason, an opponent model technique is needed to extract the maximum information gained with limited interaction. This study presents a conflict-based opponent modeling technique and compares its prediction performance with the well-known approaches in human-agent and automated negotiation experimental settings. According to the results of human-agent studies, the proposed model outpr erforms them despite the diversity of participants’ negotiation behaviors. Besides, the conflict-based opponent model estimates the entire bid space much more successfully than its competitors in automated negotiation sessions when a small portion of the outcome space was explored. This study may contribute to developing agents that can perceive their human counterparts’ preferences and behaviors more accurately, acting cooperatively and reaching an admissible settlement for joint interests.
Polish tourist facilities' engagement in the communication of the low-emission activities and sustainable development
Authors: Rutecka Paulina , Cicha Karina , Rizun Mariia , Strzelecki Artur 
Published: November 2023

Abstract
In 2021, Booking.com, one of the largest web portals for tourist facilities online reservations, started the Sustainable Travel Program. The main purpose behind it was to promote environmental consciousness among tourists as well as engage the tourist facilities owners to implement sustainable practices in their companies, and, as a consequence of such practices, reward them with a Sustainable Travel Badge. The objective of this research is to examine the engagement of Polish tourist facilities in low-emission and sustainable development activities. To meet the defined purpose, the research was conducted on the data about the facilities in Poland, included in the Booking.com Sustainable Travel Program. The study examines what types of facilities possess the sustainable badge more than others; in which voivodeships (provinces) of Poland there are more objects with the badge, and which Sustainable Travel Practices (out of 30) are realized more frequently. Such information may be useful when choosing a tourist destination, especially for tourists sensitive to environmental issues. The sustainable development practices introduced by Booking.com are mostly possible to be realized by large hotel enterprises. However, it is sometimes difficult to verify whether a certain practice is indeed implemented by a facility, or what exactly its implementation looks like in reality. The number of tourist objects engaged in the Booking.com Sustainable Travel Program has a low correlation with the level of wealth of the voivodeship where an object is located. It is justified by the fact that the wealthiest voivodeships in Poland are not necessarily the most attractive for tourists. The collected data can be a recommendation for both owners of tourist facilities and tourists regarding Polish regions and holiday destinations that meet the criteria of being sustainable, in accordance with the Booking.com guidelines.
Variational integrators and graph-based solvers for multibody dynamics in maximal coordinates
Authors: Brüdigam Jan , Sosnowski Stefan , Manchester Zachary , Hirche Sandra 
Published: November 2023

AbstractMultibody dynamics simulators are an important tool in many fields, including learning and control in robotics. However, many existing dynamics simulators suffer from inaccuracies when dealing with constrained mechanical systems due to unsuitable integrators with bad energy behavior and problematic constraint violations, for example in contact interactions. Variational integrators are numerical discretization methods that can reduce physical inaccuracies when simulating mechanical systems, and formulating the dynamics in maximal coordinates allows for easy and numerically robust incorporation of constraints such as kinematic loops or contacts. Therefore, this article derives a variational integrator for mechanical systems with equality and inequality constraints in maximal coordinates. Additionally, efficient graph-based sparsity-exploiting algorithms for solving the integrator are provided and implemented as an open-source simulator. The evaluation of the simulator shows improved physical accuracy due to the variational integrator and the advantages of the sparse solvers. Comparisons to minimal-coordinate algorithms show improved numerical robustness, and application examples of a walking robot and an exoskeleton with explicit constraints demonstrate the necessity and capabilities of maximal coordinates.
A cross-sectional study examining the nature and extent of interprofessional education in schools of pharmacy in the United Kingdom
Authors: Depasquale Clare , Cunningham Scott , Jacob Sabrina Anne , Boyter Anne , Portlock Jane , Power Ailsa , Addison Brian 
Published: November 2023

Abstract
Background
Interprofessional education can prepare the workforce for collaborative practice in complex health and social care systems.

Aim
To examine the nature and extent of interprofessional education in schools of pharmacy in the United Kingdom.

Method
An online questionnaire was developed using systems theory, published literature and input from an interprofessional expert panel; it included closed and open-ended questions and a demographic section. Following piloting, it was distributed to 31 schools of pharmacy. Descriptive statistics were used for quantitative data, and a content analysis approach for qualitative data.

Results
Ten schools of pharmacy responded. All reported delivering compulsory interprofessional education. Most (80%) reported an interprofessional steering group overseeing development. Formative and/or summative assessment varied depending on year of study. Mechanism and purpose of evaluation varied with respondents reporting Kirkpatrick Evaluation Model Levels 1–3 (100%; 80%; 70%). Two themes were identified: “Variation in Interprofessional Education Approaches and Opportunities” and “Factors Influencing Development and Implementation of Interprofessional Education”. Formal teaching was mainly integrated into other modules; various pedagogic approaches and topics were used for campus-based activities. Respondents referred to planned interprofessional education during practice-based placements; some still at pilot stage. Overall, respondents agreed that practice-based placements offered opportunistic interprofessional education, but a more focused approach is needed to maximise student pharmacists’ learning potential.

Conclusion
Most interprofessional education offered in undergraduate pharmacy curricula in the United Kingdom is campus-based; the nature and extent of which varies between programmes. Very few examples of practice-based activities were reported. Results may inform future interprofessional education curricular development.
Nonlinear Forward-Backward Splitting with Momentum Correction
Authors: Morin Martin , Banert Sebastian , Giselsson Pontus 
Published: November 2023

AbstractThe nonlinear, or warped, resolvent recently explored by Giselsson and Bùi-Combettes has been used to model a large set of existing and new monotone inclusion algorithms. To establish convergent algorithms based on these resolvents, corrective projection steps are utilized in both works. We present a different way of ensuring convergence by means of a nonlinear momentum term, which in many cases leads to cheaper per-iteration cost. The expressiveness of our method is demonstrated by deriving a wide range of special cases. These cases cover and expand on the forward-reflected-backward method of Malitsky-Tam, the primal-dual methods of Vũ-Condat and Chambolle-Pock, and the forward-reflected-Douglas-Rachford method of Ryu-Vũ. A new primal-dual method that uses an extra resolvent step is also presented as well as a general approach for adding momentum to any special case of our nonlinear forward-backward method, in particular all the algorithms listed above.
GPNMB Ameliorates Neuroinflammation Via the Modulation of AMPK/NFκB Signaling Pathway After SAH in Mice
Authors: Li Tao , Zhang Yuansheng , Lu Qixiong , Lei Li , Du Jingshu , Lu Xiaoyang 
Published: November 2023

AbstractGlycoprotein non-metastatic melanoma protein B (GPNMB) got its name from the first discovery in a cell line of non-metastatic melanoma. Later studies found that GPNMB is widely expressed in various tissues and cells of the human body, most abundant in neural tissue, epithelial tissue, bone tissue, and monocyte-macrophage system. GPNMB has been shown to have anti-inflammatory effects in a variety of neurological diseases, however, it has not been reported in subarachnoid hemorrhage (SAH). Male CD-1 mice were used and intra-arterial puncture method was applied to establish the SAH model. Exogenous recombinant GPNMB (rGPNMB) was injected intracerebroventricularly 1 h after SAH. SAH grading, brain edema and blood–brain barrier (BBB) integrity were quantified, and neurobehavioral tests were performed to evaluate the effect of GPNMB on the outcome. Dorsomorphin, the selective inhibitor on AMPK was introduced to study the downstream signaling through which the GPNMB works. Furthermore, western blot, immunofluorescence staining and ELISA were utilized to confirm the signaling. After SAH, GPNMB expression increased significantly as a result of the inflammatory response. GPNMB was expressed extensively in mouse microglia, astrocytes and neurons. The administration of rGPNMB could alleviate brain edema, restore BBB integrity and improve the neurological outcome of mice with SAH. GPNMB treatment significantly magnified the expression of p-AMPK while p-NFκB, IL-1β, IL-6 and TNF-α were suppressed; in the meantime, the combined administration of GPNMB and AMPK inhibitor could decrease the intensity of p-AMPK and reverse the quantity of p-NFκB and the above inflammatory cytokines. GPNMB has the potential of ameliorating the brain edema and neuroinflammation, protecting the BBB and improving the neurological outcome, possibly via the AMPK/NFκB signaling pathway.

Graphical Abstract
The post-materialist economic freedom puzzle
Authors: Czeglédi Pál 
Published: November 2023

AbstractCountries with a higher proportion of people with post-materialist values are freer economically than those with a lower proportion. The reasons why this is puzzling are that post-materialist values are not obviously more supportive to economic freedom than materialist ones, and that post-materialism correlates negatively with market friendliness in the West and positively outside it. The paper argues that seeing market attitudes as opinions with which people express their materialist or post-materialist identity, an equilibrium in which post-materialists are market friendly and another in which they are market unfriendly are both possible. A change in the proportion of post-materialists, however, can easily trigger a shift from one equilibrium to the other. Regressions with data from the Integrated Values Survey confirm that post-materialists are more market unfriendly when their proportion in society is high enough, but this negative effect is mitigated by their political identity, the expressiveness of the individuals themselves, the ideology of the political parties in their country, and culture. The argument casts some doubt on the claim that post-materialism is a determinant of the institutions and policies of economic freedom.