bluuebunny/crossref_metadata_2025_split huggingface dataset:
Oocyte quality is enhanced by hypoglycosylated FSH through increased cell-to-cell interaction during mouse follicle development
Authors: Converse Aubrey , Liu Zhenghui , Patel Jai C. , Shakyawar Sushil , Guda Chittibabu , Bousfield George R. , Kumar T. Rajendra , Duncan Francesca E. 
Published: October 2023

ABSTRACT
Macroheterogeneity in follicle-stimulating hormone (FSH) β-subunit N-glycosylation results in distinct FSH glycoforms. Hypoglycosylated FSH21 is the abundant and more bioactive form in pituitaries of females under 35 years of age, whereas fully glycosylated FSH24 is less bioactive and increases with age. To investigate whether the shift in FSH glycoform abundance contributes to the age-dependent decline in oocyte quality, the direct effects of FSH glycoforms on folliculogenesis and oocyte quality were determined using an encapsulated in vitro mouse follicle growth system. Long-term culture (10-12 days) with FSH21 (10 ng/ml) enhanced follicle growth, estradiol secretion and oocyte quality compared with FSH24 (10 ng/ml) treatment. FSH21 enhanced establishment of transzonal projections, gap junctions and cell-to-cell communication within 24 h in culture. Transient inhibition of FSH21-mediated bidirectional communication abrogated the positive effects of FSH21 on follicle growth, estradiol secretion and oocyte quality. Our data indicate that FSH21 promotes folliculogenesis and oocyte quality in vitro by increasing cell-to-cell communication early in folliculogenesis, and that the shift in in vivo abundance from FSH21 to FSH24 with reproductive aging may contribute to the age-dependent decline in oocyte quality.
Upregulation of fibronectin and its integrin receptors – an adaptation to isolation stress that facilitates tumor initiation
Authors: Wu Chengsheng , Weis Sara M. , Cheresh David A. 
Published: October 2023

ABSTRACT
Tumor initiation at either primary or metastatic sites is an inefficient process in which tumor cells must fulfill a series of conditions. One critical condition involves the ability of individual tumor-initiating cells to overcome ‘isolation stress’, enabling them to survive within harsh isolating microenvironments that can feature nutrient stress, hypoxia, oxidative stress and the absence of a proper extracellular matrix (ECM). In response to isolation stress, tumor cells can exploit various adaptive strategies to develop stress tolerance and gain stemness features. In this Opinion, we discuss how strategies such as the induction of certain cell surface receptors and deposition of ECM proteins enable tumor cells to endure isolation stress, thereby gaining tumor-initiating potential. As examples, we highlight recent findings from our group demonstrating how exposure of tumor cells to isolation stress upregulates the G-protein-coupled receptor lysophosphatidic acid receptor 4 (LPAR4), its downstream target fibronectin and two fibronectin-binding integrins, α5β1 and αvβ3. These responses create a fibronectin-rich niche for tumor cells, ultimately driving stress tolerance, cancer stemness and tumor initiation. We suggest that approaches to prevent cancer cells from adapting to stress by suppressing LPAR4 induction, blocking its downstream signaling or disrupting fibronectin–integrin interactions hold promise as potential strategies for cancer treatment.
Assessment of landmark detection in cephalometric radiographs with different conditions of brightness and contrast using the an artificial intelligence software
Authors: Menezes Liciane dos Santos , Silva Thaísa Pinheiro , Lima dos Santos Marcos Antônio , Hughes Mariana Mendonça , Mariano Souza Saulo dos Reis , Leite Ribeiro Patrícia Miranda , Freitas Paulo Henrique Luiz de , Takeshita Wilton Mitsunari 
Published: October 2023

Objectives
To evaluate the reliability and reproducibility of an artificial intelligence (AI) software in identifying cephalometric points on lateral cephalometric radiographs considering four settings of brightness and contrast.

Methods and materials
Brightness and contrast of 30 lateral cephalometric radiographs were adjusted into four different settings. Then, the control examiner (ECont), the calibrated examiner (ECal), and the CEFBOT AI software (AIs) each marked 19 cephalometric points on all radiographs. Reliability was assessed with a second analysis of the radiographs 15 days after the first one. Statistical significance was set at p &lt; 0.05.

Results:
Reliability of landmark identification was excellent for the human examiners and the AIs regardless of the type of brightness and contrast setting (mean intraclass correlation coefficient &gt;0.89). When ECont and ECal were compared for reproducibility, there were more cephalometric points with significant differences on the x-axis of the image with the highest contrast and the lowest brightness, namely N(p = 0.033), S(p = 0.030), Po(p &lt; 0.001), and Pog’(p = 0.012). Between ECont and AIs, there were more cephalometric points with significant differences on the image with the highest contrast and the lowest brightness, namely N(p = 0.034), Or(p = 0.048), Po(p &lt; 0.001), A(p = 0.042), Pog’(p = 0.004), Ll(p = 0.005), Ul(p &lt; 0.001), and Sn(p = 0.001).

Conclusions
While the reliability of the AIs for cephalometric landmark identification was rated as excellent, low brightness and high contrast seemed to affect its reproducibility. The experienced human examiner, on the other hand, did not show such faulty reproducibility; therefore, the AIs used in this study is an excellent auxiliary tool for cephalometric analysis, but still depends on human supervision to be clinically reliable.
How does the clinical and tomographic appearance of MRONJ influences its treatment prognosis?
Authors: Moreno Rabie Catalina , García-Larraín Santiago , Contreras Diez de Medina David , Cabello-Salazar Isadora , Fontenele Rocharles Cavalcante , Van den Wyngaert Tim , Jacobs Reinhilde 
Published: October 2023

Objectives:
To identify clinical and tomographic prognostic factors for conservative and surgical treatment of medication-related osteonecrosis of the jaws (MRONJ).

Methods:
A retrospective search identified patients treated with antiresorptive drugs (ARDs), diagnosed with Stage 1, 2 or 3 MRONJ, and having CBCT scans previous to conservative or surgical treatment. Following data collection, imaging assessment of the following parameters on each MRONJ site was performed: involvement of teeth and/or implants, presence of osteosclerosis, osteolysis, sequestrum formation, periosteal reaction, and pathological fractures. For statistical analysis, patients and lesions were divided into conservative and surgical treatment. Comparisons were made between successful and unsuccessful outcomes. Significance was set at p ≤ 0.05.

Results:
115 ARD-treated patients who developed 143 osteonecrosis lesions were selected. 40 patients and 58 lesions received conservative treatment, of which 14 patients (35%) and 25 lesions (43%) healed. Additionally, 75 patients and 85 lesions underwent surgery, with 48 patients (64%) and 55 lesions (65%) that healed. Clinical and tomographic risk factors for conservative treatment were MRONJ staging, tooth involvement, extensive osteosclerosis, and deep sequestrum formation (p &lt; 0.05). Complementarily, poor prognostic indicators for surgical therapy were a short bisphosphonate (BP) holiday, MRONJ staging, absence of sequestrum formation, and presence of periosteal reaction (p &lt; 0.05).

Conclusions:
Lesions at Stage 3 MRONJ, with tooth involvement, or sequestrum formation showed poor outcomes when conservative treatment is chosen. Alternatively, surgical treatment is most effective when BPs are discontinued, in Stage 1 lesions, in the presence of sequestrum formation, and absence of periosteal reaction.
Association between intrapartum fetal pulse oximetry and adverse perinatal and long-term outcomes: a systematic review and meta-analysis protocol
Authors: Mitchell Jill M. , Walsh Siobhan , O'Byrne Laura J. , Conrick Virginia , Burke Ray , Khashan Ali S. , Higgins John , Greene Richard , Maher Gillian M. , McCarthy Fergus P. 
Published: October 2023

Background: Current methods of intrapartum fetal monitoring based on heart rate, increase the rates of operative delivery but do not prevent or accurately detect fetal hypoxic brain injury. There is a need for more accurate methods of intrapartum fetal surveillance that will decrease the incidence of adverse perinatal and long-term neurodevelopmental outcomes while maintaining the lowest possible rate of obstetric intervention. Fetal pulse oximetry (FPO) is a technology that may contribute to improved intrapartum fetal wellbeing evaluation by providing a non-invasive measurement of fetal oxygenation status. Objective: This systematic review and meta-analysis aims to synthesise the evidence examining the association between intrapartum fetal oxygen saturation levels and adverse perinatal and long-term outcomes in the offspring. Methods: We will include randomised control trials (RCTs), cohort, cross-sectional and case-control studies which examine the use of FPO during labour as a means of measuring intrapartum fetal oxygen saturation and assess its effectiveness at detecting adverse perinatal and long-term outcomes compared to existing intrapartum surveillance methods. A detailed systematic search of PubMed, EMBASE, CINAHL, The Cochrane Library and Web of Science will be conducted following a detailed search strategy until August 2023. Three authors will independently review titles, abstracts and full text of articles. Two reviewers will independently extract data using pre-defined data extraction and assess the quality using the Risk of Bias tool for RCTs and Newcastle-Ottawa Scale for observational studies. We will use random-effects meta-analysis for each exposure-outcome association to calculate pooled estimates using the generic variance method. This systematic review will follow the Preferred Reporting Items for Systematic reviews and Meta-analyses guidelines. PROSPERO registration: CRD42023457368 (04/09/2023)
Distributional Robustness and Inequity Mitigation in Disaster Preparedness of Humanitarian Operations
Authors: Li Hongming , Delage Erick , Zhu Ning , Pinedo Michael , Ma Shoufeng 
Published: October 2023

Problem definition: In this paper, we study a predisaster relief network design problem with uncertain demands. The aim is to determine the prepositioning and reallocation of relief supplies. Motivated by the call of the International Federation of Red Cross and Red Crescent Societies (IFRC) to leave no one behind, we consider three important practical aspects of humanitarian operations: shortages, equity, and uncertainty. Methodology/results: We first employ a form of robust satisficing measure, which we call the shortage severity measure, to evaluate the severity of the shortage caused by uncertain demand in a context with limited distribution information. Because shortages often raise concerns about equity, we then formulate a mixed-integer lexicographic optimization problem with nonconvex objectives and design a new branch-and-bound algorithm to identify the exact solution. We also propose two approaches for identifying optimal postdisaster adaptable resource reallocation: an exact approach and a conservative approximation that is more computationally efficient. Our case study considers the 2010 Yushu earthquake, which occurred in northwestern China, and demonstrates the value of our methodology in mitigating geographical inequities and reducing shortages. Managerial implications: In our case study, we show that (i) incorporating equity in both predisaster deployment and postdisaster reallocation can produce substantially more equitable shortage prevention strategies while sacrificing only a reasonable amount of total shortage; (ii) increasing donations/budgets may not necessarily alleviate the shortage suffered by the most vulnerable individuals if equity is not fully considered; and (iii) exploiting disaster magnitude information when quantifying uncertainty can help alleviate geographical inequities caused by uncertain relief demands. Funding: This work was supported by the Natural Sciences and Engineering Research Council of Canada [Grant RGPIN-2016-05208], the National Natural Science Foundation of China [Grants 71971154, 72010107004, 72091214, and 72122015], and the Canada Research Chairs [Grant CRC-2018-00105]. Supplemental Material: The online appendices are available at https://doi.org/10.1287/msom.2023.1230 .
ZnO nanorod and rGO based nanocomposite decorated with Au nanoparticles for enhanced UV photodetection
Authors: Chetry Deepjyoti , Basumatary Pritymala , Das Karen , Kakoty Priyanka 
Published: October 2023

A comprehensive analysis of a hydrothermally prepared Au nanoparticle decorated nanocomposite of reduced graphene oxide (rGO) and a ZnO nanorod (NR) for possible use as a UV photodetector is presented. The effect of rGO loading in ZnO and incorporation of Au decoration in the best combination of rGO/ZnO for possible enhancement of a photocatalytic effect are experimented. X-ray diffraction, scanning electron microscopy, energy diffraction, and UV-Vis spectroscopy are done for morphological, structural, and optical attribute analysis of the prepared materials. An increase in photocurrent is seen from 2.19 nA to 6.14 mA in dark and UV environments (370 nm) at 5 V bias voltage for the Au decorated nanocomposite, which is found to be better among the experimented composites. The responsivity and detectivity of the Au decorated nanocomposite are analyzed with the increase in incident UV light intensities. The findings are analyzed, and an explanation of the detailed UV photodetection mechanism is outlined in this paper.
Introduction to the special issue on “The language of science fiction”
Authors: Rüdiger Sofia , Lange Claudia 
Published: October 2023

Abstract
In this introduction, we provide a short rationale for the genesis of the special issue on “The language of science fiction” and introduce its main theme – science fiction, with particular consideration of the language of estrangement – and main methodological framework – corpus linguistics. In addition, we give an overview of the contributions and motivate their grouping into four parts: (1) the influence of science fiction on non-fictional language, (2) sociolinguistic variation, (3) science fiction and the mind, and (4) lexis and literature.
Der distanziert-lakonische Typus als Variante der subjektiven Wahrnehmung des schulischen Auslandsaufenthaltes
Authors: Schade Kai , Oesterhaus Charlyn-Mariella 
Published: October 2023

Zusammenfassung
Obwohl privat organisierte Auslandsaufenthalte mittlerweile eine etablierte Praxis schulischer Werdegänge darstellen, hat eine systematische Betrachtung der subjektiven Bedeutung dieser Auslandsaufenthalte für die Teilnehmer:innen bisher kaum Beachtung gefunden. Dieser blinde Fleck der empirischen Betrachtung überrascht, da Auslandsaufenthalte zwar mit der Unterstützung der Eltern umgesetzt, jedoch von den Teilnehmer:innen alleine durchgeführt werden. Gleichzeitig werden Auslandsaufenthalte, nicht zuletzt von den Austauschorganisationen, als selbstverständlich autonomiefördernd angesehen und beworben. Ohne das autonomiefördernde Potential in Abrede zu stellen, möchten wir in unserem Beitrag auf Ambivalenzen der autonomisierenden Ablösung hinweisen. In unseren fallrekonstruktiven Untersuchungen treffen wir den Typus einer distanziert-lakonischen subjektiven Wahrnehmung des Auslandsaufenthaltes an. Diesen Typus interpretieren wir als spezifische Bearbeitung der strukturellen Autonomieambivalenz des Auslandsaufenthaltes.
PARIS undergoes liquid–liquid phase separation and poly(ADP‐ribose)‐mediated solidification
Authors: Kang Hojin , Park Soojeong , Jo Areum , Mao Xiaobo , Kumar Manoj , Park Chi‐Hu , Ahn Jee‐Yin , Lee Yunjong , Choi Jeong‐Yun , Lee Yun‐Song , Dawson Valina L , Dawson Ted M , Kam Tae‐In , Shin Joo‐Ho 
Published: October 2023

AbstractZNF746 was identified as parkin‐interacting substrate (PARIS). Investigating its pathophysiological properties, we find that PARIS undergoes liquid–liquid phase separation (LLPS) and amorphous solid formation. The N‐terminal low complexity domain 1 (LCD1) of PARIS is required for LLPS, whereas the C‐terminal prion‐like domain (PrLD) drives the transition from liquid to solid phase. In addition, we observe that poly(ADP‐ribose) (PAR) strongly binds to the C‐terminus of PARIS near the PrLD, accelerating its LLPS and solidification. N‐Methyl‐N′‐nitro‐N‐nitrosoguanidine (MNNG)‐induced PAR formation leads to PARIS oligomerization in human iPSC‐derived dopaminergic neurons that is prevented by the PARP inhibitor, ABT‐888. Furthermore, SDS‐resistant PARIS species are observed in the substantia nigra (SN) of aged mice overexpressing wild‐type PARIS, but not with a PAR binding‐deficient PARIS mutant. PARIS solidification is also found in the SN of mice injected with preformed fibrils of α‐synuclein (α‐syn PFF) and adult mice with a conditional knockout (KO) of parkin, but not if α‐syn PFF is injected into mice deficient for PARP1. Herein, we demonstrate that PARIS undergoes LLPS and PAR‐mediated solidification in models of Parkinson's disease.
Survei Sarana Dan Prasarana Pendidikan Jasmani Sekolah Dasar Di Kecamatan Winong Kabupaten Pati Tahun 2021
Authors: Rahman Arif , Irsyada Roas 
Published: October 2023

Arif Rahman,. 2021. Survey of Physical Education Facilities and Infrastructure Elementary School in Winong Sub-District Pati Regency. A Final Project. Physical Education, Health and Recreation, Faculty of Sport Sciences, Universitas Negeri Semarang. Advisor: Roas Irsyada S.pd.,M.pd.
Keywords: Physical Education, survey, facilities, infrastructure.
The background of this research is based on preliminary observation indicates that there is need for data about the availability and condition of facilities and infrastructure to support physical education learning in Kedu Sub-District Elementary School, Temanggung Regency. The purpose of this research is to know the results conditions of physical education learning facilities and infrastructure at the elementary school in Kedu Sub-District Temanggung Regency.
The research method used is a survey with a quantitative descriptive approach. The research site is located in Temanggung Regency with a research target of 10 elementary schools in Winong Sub-district Pati Regency. Data collection techniques using quota sampling techniques. Instruments used using observations, interviews with Principals and Physical Education Teachers, observation sheets and documentation. Data collection includes the number of tools, the number of tools, the number of facilities, the condition of the tool, the condition of the tool and the condition of the facility. The analysis used is quantitative descriptive by classifying the types of data obtained from observation sheets and grouped.
Based on the data analysis that has been carried out in the Survey of Physical Education Facilities and Infrastructure in Public Elementary Schools in Winong District, Pati Regency, it can be concluded that the results of the study on the condition of the number of physical education learning facilities and infrastructure in Public and Private Elementary Schools in Winong District, Pati Regency from 10 It is known that all elementary schools are in the Enough category (100%). Then the condition of the number of Physical Education learning tools in the State Elementary School, Winong District, Pati Regency, out of 10 elementary schools it is known that there are 2 schools in the good category (20%), there are 8 elementary schools that fall into the sufficient category (80%) and 0 schools are in the good category. less ( 0% ).
This research concludes that the facilities and infrastructures in elementary school in Winong sub-district Pati Regency are in medium category. The suggestion given by researchers is for the Pati Regency government to more attention to the facilities and infrastructure available at the elementary school in Winong sub-district and physical education teachers can support and modify the facilities and infrastructure available at the school especially in Public and Private Elementary Schools in the Winong District, Pati Regency.
Reproduction in life and death: should cancer patients with a poor prognosis be offered fertility preservation interventions?
Authors: Jones Georgina L , Folan Anne-Mairead , Phillips Bob , Anderson Richard A , Ives Jonathan 
Published: October 2023

In the context of a cancer diagnosis, fertility preservation interventions are used to mitigate the potential impact of gonadotoxic cancer treatment upon fertility. They provide patients with cancer the option to freeze their reproductive material to have their own biological child following treatment. The evidence suggests some clinicians are less likely to have fertility preservation discussions with patients who have an aggressive or metastatic cancer which has a poor prognosis. Although this is contrary to current policy recommendations, there is a lack of guidance relating to offering fertility preservation in the context of a poor prognosis to support clinicians. Controversy surrounds posthumous reproduction, and whether the wishes of the cancer patient, when living and deceased should take precedence over others’ well-being. We consider the question of whether cancer patients with a poor prognosis should be offered fertility preservation from an ethics perspective. We structure the paper around key arguments to which multiple ethical principles might pertain, first establishing a central argument in favour of offering fertility preservation based on respect for autonomy, before exploring counterarguments. We conclude by proposing that a defeasible assumption should be adopted in favour of offering fertility preservation to all cancer patients who might benefit from it. It is important to recognise that patients could benefit from fertility preservation in many ways, and these are not limited to having a parenting experience. The burden of proof rests on the clinician in collaboration with their multidisciplinary team, to show that there are good grounds for withholding the offer.

Lay summary
When a person is diagnosed with cancer, they may wish to consider undergoing fertility preservation procedures. These procedures give patients a chance to have their own biological child after completing cancer treatment. However, research suggests that cancer patients who have a poor prognosis are less likely to be offered fertility preservation treatment. In this paper, we consider the ethical implications of offering (or not) fertility preservation to this patient group, including using their sperm or eggs to reproduce after their death. We conclude that fertility preservation treatments should be offered to all cancer patients who might benefit from it, and we outline the many ways that benefit from this treatment can be gained. The decision to withhold the offer of fertility preservation treatment should be made between the patient’s clinician and their wider care team. They must be able to provide good reasons to explain why it was withheld.