bluuebunny/crossref_metadata_2025_split huggingface dataset:
Comparison of Single Knee Arthroplasty and Bilateral Knee Arthroplasty in Haemophiliacs During a Single Operation: A Systematic Review and Meta‐Analysis
Authors: Zhang Yi , Pei Hang , Wang Chao , Wang Guanyin , Shen Zan , Hua Jiang , He Bangjian 
Published: January 2025

AbstractBackgroundArthroplasty is the standard treatment for end‐stage haemophilic knee arthritis; however, the choice between single knee arthroplasty (SKA) and bilateral knee arthroplasty (BKA) in a single operation remains controversial due to the risks specific to haemophiliacs.MethodsTwo independent researchers conducted searches across CNKI, CBM, Wanfang, PubMed, Cochrane Library, Embase, and Web of Science, with the last search performed on 15 October 2024. Study results include joint function, complication and various cost. Literature quality was assessed using the Newcastle–Ottawa Scale (NOS). Outcomes were evaluated with fixed‐effects or random‐effects models, while heterogeneity and publication bias were also assessed.ResultsNine studies involving 309 haemophilia patients were included, with 166 in SKA group and 143 in BKA group. No statistically significant differences were observed between the SKA and BKA groups in range of motion (95% CI: −0.22 [−3.57, 3.13], p = 0.90), Hospital for Special Surgery score (95% CI: −2.13 [−4.89, 0.64], p = 0.13), flexion degree (95% CI: −2.38 [−7.22, 2.46], p = 0.33), cost (95% CI: −0.24 [−0.94, 0.45], p = 0.49), complication rate (95% CI: 1.31 [−0.79, 2.17], p = 0.29), hospital stay (95% CI: 0.25 [−2.06, 2.57], p = 0.83), and coagulation factor usage (p = 0.49). However, The SKA group outperformed the BKA group in terms of operative time, postoperative drainage, and transfusion volume (p < 0.001).ConclusionsOur study indicates that, apart from differences in operative time, transfusion volume, and blood loss, SKA and BKA show no significant differences in postoperative joint function, complication rates, or costs.
Selection effects in the births of mutual funds
Authors: de Souza André 
Published: January 2025

AbstractNewborn funds disproportionately hold popular stocks, representing long‐lived strategic choices. This suggests that when choosing strategies in which to launch new funds, families do not consider only expectations for their own performance but also consider investor sentiment toward those strategies. The two motives for entry result in an interaction effect between competitive entry and strategy popularity, which affects performance and flows for both existing and newborn funds. Newborn funds' expectations for performance are partly driven by fund manager skill in those strategies, but this is not the only factor, leaving a role for time‐varying investment opportunities.
Medication Use Quality and Safety in Older Adults: 2023 Update
Authors: Hart Laura A. , Vo Su , Hanlon Joseph T. , Schmader Kenneth E. , Gray Shelly L. 
Published: January 2025

ABSTRACTImproving the quality of medication use and medication safety are important priorities for healthcare providers who care for older adults. The objective of this article was to identify four exemplary articles with this focus in 2023. We selected high‐quality studies that advanced this field of research. The chosen articles cover domains related to deprescribing/discontinuation, optimizing medication use, medication safety/adverse drug events, and other. The first study was a randomized clinical trial evaluating the efficacy of the patient‐centered Shed‐MEDS deprescribing intervention among older adults transitioning from the hospital to postacute care facilities (domain: deprescribing/discontinuation). The second study, a retrospective cohort study among Medicare beneficiaries, described the phenomenon of a prescribing cascade relic and evaluated continued potassium use after discontinuation of a loop diuretic (domain: optimizing medication use). The third study was a systematic review and meta‐analysis describing the prevalence of drug–drug interactions among community‐dwelling older adults (domain: other). Lastly, the fourth study was a retrospective cohort study among Medicare beneficiaries that evaluated concurrent gabapentin and opioid use and risk of mortality (domain: medication safety). Collectively, this review succinctly highlights pertinent topics related to promoting safe use of medications and promotes awareness of optimizing older adults' medication regimens.
Who Owns the Indonesian Countryside? From Corporate Capital to Capitalist Farmers and Landlord Capitalists
Authors: Habibi Muchtar 
Published: January 2025

ABSTRACTMany recent studies on Indonesia have underlined the importance of corporate capital, either private or state‐owned, as the dominant actors in the countryside. This paper argues that in the different contexts of rurality in Indonesia, noncorporate capital, including capitalist farmers and landlord capitalists, functions as a prominent segment of the rural ruling class. The paper develops an understanding of these dominant actors by exploring internal differentiation among them. Different fractions within both capitalist farmers, including ‘typical capitalist farmers’, ‘politico‐bureaucrat capitalist farmers’ and ‘professional capitalist farmers’, and landlord capitalists, including ‘present landlords’ and ‘absentee landlords’, shape the nature of their cooperation and competition and how they relate to other classes. The internal dynamics of the rural ruling class shape the organization of commodity production and class reproduction (accumulation) strategies in specific settings. Drawing on the processes of agrarian change in rural Java and Sumatra, this paper sheds light on the nature of the rural ruling class, an important segment of the current trajectories of capitalism in Indonesia. By doing so, it adds a new perspective on the broader power relations in the countryside.
Opportunistic assessment of steatotic liver disease in lung cancer screening eligible individuals
Authors: Weiss Jakob , Bernatz Simon , Johnson Justin , Thiriveedhi Vamsi , Mak Raymond H. , Fedorov Andriy , Lu Michael T. , Aerts Hugo J. W. L. 
Published: January 2025

AbstractBackgroundSteatotic liver disease (SLD) is a potentially reversible condition but often goes unnoticed with the risk for end‐stage liver disease.PurposeTo opportunistically estimate SLD on lung screening chest computed tomography (CT) and investigate its prognostic value in heavy smokers participating in the National Lung Screening Trial (NLST).Material and methodsWe used a deep learning model to segment the liver on non‐contrast‐enhanced chest CT scans of 19,774 NLST participants (age 61.4 ± 5.0 years; 41.2% female) at baseline and on the 1‐year follow‐up scan if no cancer was detected. SLD was defined as hepatic fat fraction (HFF) ≥5% derived from Hounsfield unit measures of the segmented liver. Participants with SLD were categorized as lean (body mass index [BMI] < 25 kg/m2) and overweight (BMI ≥ 25 kg/m2). The primary outcome was all‐cause mortality. Cox proportional hazard regression assessed the association between (1) SLD and mortality at baseline and (2) the association between a change in HFF and mortality within 1 year.ResultsThere were 5.1% (1000/19,760) all‐cause deaths over a median follow‐up of 6 (range, 0.8–6) years. At baseline, SLD was associated with increased mortality in lean but not in overweight/obese participants as compared to participants without SLD (hazard ratio [HR] adjusted for risk factors: 1.93 [95% confidence interval 1.52–2.45]; p = 0.001). Individuals with an increase in HFF within 1 year had a significantly worse outcome than participants with stable HFF (HR adjusted for risk factors: 1.29 [1.01–1.65]; p = 0.04).ConclusionSLD is an independent predictor for long‐term mortality in heavy smokers beyond known clinical risk factors.
Multicenter validation of secondary hemophagocytic lymphohistiocytosis diagnostic criteria
Authors: Lachmann Gunnar , Heeren Patrick , Schuster Friederike S. , Nyvlt Peter , Spies Claudia , Feinkohl Insa , Schenk Thomas , Ammouri Wafa , Debaugnies France , Galicier Lionel , Jia Yuan , Meena Nikhil , Nagant Carole , Neth Olaf , Nierkens Stefan , San Martin Juan , Sun Hao Wei (Linda) , Wang Yini , Wang Zhao , Yoon Jae‐Ho , Brunkhorst Frank M. , La Rosée Paul , Janka Gritta , Lachmann Cornelia 
Published: January 2025

AbstractBackground:Five fulfilled hemophagocytic lymphohistiocytosis (HLH)‐2004 criteria, and the HScore are widely used and recommended by international expert consensus to diagnose secondary HLH. Both diagnostic scores have never been validated in heterogeneous patient cohorts of secondary HLH patients. We aimed to systematically optimize and validate diagnostic criteria of secondary HLH using a multicenter approach.Methods:We developed optimized criteria in our cohort of critically ill patients as a first step. We next validated these new criteria together with the original and modified HLH‐2004 criteria as well as the HScore using original data of 13 published cohorts, which were identified by a systematic literature search.Results:The best performing HLH diagnostic criteria sets over all 13 validation cohorts were the original HLH‐2004 criteria with a decreased cut‐off (cut‐off 4, mean sensitivity 86.5%, mean specificity 86.1%), followed by the revised HLH‐2004 criteria (natural killer cell activity removed; cut‐off 4, mean sensitivity 83.8%, mean specificity 87.8%) and the HScore (cut‐off 169, mean sensitivity 82.4%, mean specificity 87.6%). Our newly developed HLH diagnostic criteria showed inferior performance. Ferritin ≥500 µg/L had 94.0% mean sensitivity over all cohorts.Conclusions:In this first multicenter validation study, four fulfilled HLH‐2004 criteria and an HScore of 169 were suitable to diagnose secondary HLH, which will lead to rapid diagnosis and improved patient outcomes. Ferritin proved as a reliable HLH screening marker. Our results should be taken into account in clinical recommendations and in designing new studies.
Daily association between feeling needed and useful and adolescent emotional and social well‐being: Differences by suicidal ideation
Authors: Chiang Shou‐Chun 
Published: January 2025

AbstractPrior research suggests that feeling needed and useful plays a central role in adolescent psychosocial development and well‐being. However, little is known about whether feeling needed and useful benefits adolescents' well‐being in daily life, especially for those with suicidal ideation. The current study examined the daily association between feeling needed and useful and emotional and social well‐being in a daily diary sample of adolescents (N = 122; Mage = 12.64) with and without suicidal ideation. Results from multilevel modeling showed that on days when youth experienced higher levels of feeling needed and useful, they reported lower negative emotions, higher positive emotions, and increased family connectedness. Furthermore, significant moderation effects indicated that daily feelings of being needed and useful were associated with higher positive emotions and peer connectedness only for youth with suicidal ideation. The findings support the importance of feeling needed and useful in adolescent development and highlight its beneficial effects among adolescents at risk for suicide.
Evaluation of the Effect of Bacteriophages and Organic Acids as a Feed Additive to Reduce Salmonella enteritidis in Challenged Chickens
Authors: Saleh Hassan , Mirakzehi Mohammad Taher , bidokhti Hosin Moradi , Kazemi Mohsen 
Published: January 2025

ABSTRACTThis study aimed to compare the effects of dietary supplementation of bacteriophage (BP) and acidifiers on performance, meat quality, morphology, and intestinal microbiota in chickens challenged and unchallenged with Salmonella enteritidis (SE) and also to investigate the possibility of replacing them in the diet with antibiotics. A total of 1760 male Ross (308) chicks were randomly assigned to 11 dietary treatments (8 pens/with 20 male chickens in each). Dietary treatments were as follows: SE‐uninfected (negative control (NC), a basal diet without supplemention; NC+ 500 g/t BP (NBP1); NC+ 1000 g/t BP (NBP2); NC+ 300 mg/kg acidifier A (NAA); NC+ 300 mg/kg acidifier B (NAB)) and SE‐infected (positive control (PC), a basal diet without supplemention; PC+ 40 mg/kg Antibiotic enrofloxacin (PA); PC+ 500 g/t BP (PBP1); PC+ 1000 g/t BP (PBP2); PC+ 3000 mg/kg acidifier A (PAA); PC+ 3000 mg/kg acidifier B (PAB)). At 13 D birds in challenged groups were orally gavaged with 1 mL bacterial suspension containing approximately 108 CFU Salmonella enterica. The results indicated that chicks challenged with SE impaired performance so that BWG and FI significantly decreased and FCR increased (p < 0.05). Diets containing a high dose of BP increased BW and improved FCR in challenged and unchallenged chickens. The quality of breast meat showed a decline in oxidation in chickens challenged with SE (p < 0.05). The inclusion of bacteriophage in the diet of chickens (1000 g/t) improved the L*, b*, and oxidation of meat. The use of bacteriophage and acidifier A in the diet significantly increased the Lactobacillus, and LAB count, especially in the challenged groups. The challenge of chickens with SE decreased the villus height and crypt depth in different parts of the small intestine (p < 0.05). The results of the present study suggested that 1000 g/t of BP probably improves chicken performance by increasing beneficial bacteria and decreasing pathogenic bacteria. Also, bacteriophage showed an improvement in the performance reduction of chickens with Salmonella infection. In addition, improved meat quality and beneficial changes in the microbiome and intestinal morphology indicate the effectiveness of BP as an alternative antibiotic growth promoter in broiler diets.
Not enough: Medicaid expansion, medical debt, and cost avoidance in rural American Indian and Alaska Native households
Authors: Hubbard Sean 
Published: January 2025

AbstractPurposeDespite expanding health insurance coverage under the Patient Protection and Affordable Care Act (ACA), many Americans struggle with financial barriers to health care. Medicaid expansion was meant to help alleviate these barriers, particularly for rural communities, but has shown mixed results. The American Indian and Alaska Native (AI/AN) community, which faces both racial and geographic disparities, is a group that should benefit from Medicaid expansion. This paper examines differences in medical debt and cost avoidance for rural American Indian and Alaskan Native households in Medicaid expansion and nonexpansion states.MethodsThis study uses data from the National Financial Capability Study in binomial logistic regression models to examine whether AI/AN households in rural areas are more likely to have medical and engage in cost avoidance than their urban counterparts.FindingsThe results show no differences between Medicaid expansion status but do find a higher likelihood of medical debt for those living in rural areas. The results also show a higher likelihood of medical debt and cost avoidance for those living farther from Indian Health Services (IHS)/Tribal health care facilities.Discussion/ConclusionsThe results indicate that rural AI/AN individuals continue to face financial barriers to health care despite the expansion of Medicaid under the ACA. This suggests that rural AI/AN individuals are seeking care outside of the IHS/Tribal system due to limited access to IHS providers. Addressing these barriers may require policies and programs focusing on rural AI/AN communities.
Development and Evaluation of a Virtual Reality Intervention for Reducing Exposure to Endocrine Disruptors in Female Adolescents: A Pilot Study
Authors: Park SoMi , Hwang Yun Jeong , Chung ChaeWeon 
Published: January 2025

ABSTRACTPurposeThis study aimed to develop a virtual reality (VR) intervention for reducing exposure to endocrine disruptors (EDs) and examined the effect of the intervention among Korean adolescent girls.Design and MethodsA methodological design was employed involving five phases for developing the VR tool and its evaluation of validity testing. The five development phases were conducted through (1) a literature review and surveys to select appropriate VR content for adolescents’ snack shopping, (2) a VR scenario composition based on the information‐motivation‐behavioral (IMB) skills model, (3) implementation of the VR tool using Oculus Quest 2, (4) heuristic and usability evaluations of the VR tool, and (5) the confirmation of final maintenance. For the evaluation, a one‐group pre‐ and post‐test design was utilized with a convenience sample of 19 adolescent girls who were recruited from a high school located in W city. Knowledge about EDs and sensitivity to women's reproductive health problems were measured using a self‐administered questionnaire.ResultsThe prototype of a 15‐min VR intervention was developed based on the waterfall model and evaluation criteria yielded acceptable results through content validity, heuristic evaluation, and usability test. The Wilcoxon signed‐rank test showed significant differences in knowledge about EDs (U = 3.57, p < 0.001) and sensitivity to women's reproductive health problems (U = 4.36, p < 0.001) between pre‐ and post‐intervention.Practice ImplicationsThe VR intervention was found to be applicable and effective for reducing exposure to EDs in female adolescents. School and community health centers need to expand the application of VR‐based health education to provide adolescents with a conducive environment for engaging in health behaviors and enhancing learning experiences.
Long‐Term Effects of Direct‐Acting Antivirals on Hepatitis C: Trends in Liver Disease–Related Hospitalisations in Italy
Authors: Mennini Francesco Saverio , Sciattella Paolo , Simonelli Claudia , Marcellusi Andrea , Rosato Stefano , Kondili Loreta A. 
Published: January 2025

ABSTRACTThis study aimed to evaluate the effectiveness of direct‐acting antivirals (DAAs) on hepatitis C virus (HCV) hospitalisation trends in Italy, the country with not only the highest burden of HCV‐related disease but also the highest number of patients treated for chronic HCV infection in Europe. Incident hospital discharge records in Italy from 2012 to 2019 that included a liver cirrhosis diagnosis without mention of alcohol, hepatocellular carcinoma (HCC), HCV and liver cirrhosis without mention of alcohol and/or HCC, cirrhosis with mention of alcohol, as defined by the International Classification of Diseases (ICD‐9‐CM) were reviewed. An interrupted time series analysis compared the incidence of cirrhosis and HCC before and after the introduction of DAAs (Year 2015). Overall, non‐alcoholic cirrhosis significantly decreased after the introduction of DAAs (β3 = 0.03) and for those 40–59 years of age (β3 = 0.025). HCV with cirrhosis and/or HCC significantly reduced overall for those aged 40–59 and older than 60 (). HCC‐related hospitalisation rates significantly decreased in patients younger than 60 (). Cirrhosis‐related hospitalisations with mention of alcohol did not differ during the study period before and after the year 2015 (). There was a significant reduction in HCV‐related hospitalisations throughout Italy after introducing DAAs.
Immunological Poetics and Postcolonial Echoes: Traversing the Medical Narratives From T.S. Eliot to J.M. Coetzee
Authors: Liu Huiming 
Published: January 2025

ABSTRACTThis article explores the intersection of immunological discourse and literary narrative through the works of T.S. Eliot and J.M. Coetzee. The paper examines the early twentieth‐century shift from holistic disease models to germ theory, paralleling this scientific evolution with Eliot's use of chemical metaphors in “Tradition and the Individual Talent.” Eliot's essay is analyzed alongside scientific insights from scholars like Michael Whitworth and Kevin Brazil, highlighting the blend of personal insight and historical awareness in poetic and scientific innovation. This analysis extends to Coetzee's Age of Iron, contrasting Eliot's impersonal poetics with Coetzee's nuanced exploration of cancer, apartheid, and racial and gendered bodies. Through an immunological lens, the paper delves into how literature can challenge canonical boundaries, advocate for inclusive narratives, and foster cross‐racial empathy. By drawing parallels between medical narratives and literary expressions of illness and identity, it proposes literature as a means to navigate and reconcile the divides between health, the body, and the postcolonial other.
Genetic Variants of GBP4: Reduced Risks for Drug‐Induced Acute Liver Failure in Non‐Finnish European Population
Authors: Liao Tsung‐Jen , Xia Menghang , Hayashi Paul , Pan Bohun , Aithal Guruprasad P. , Lucena M. Isabel , Andrade Raúl J. , Rule Jody A. , Lee William M. , Rakela Jorge , Huang Ruili , Chen Minjun 
Published: January 2025

ABSTRACTBackground and AimsAcute liver failure (ALF) is a serious condition, typically in individuals without prior liver disease. Drug‐induced ALF (DIALF) constitutes a major portion of ALF cases. Our research aimed to identify potential genetic predispositions to DIALF.MethodsWe analysed the potential genetic variants associated with DIALF using the whole exome sequencing data from 75 cases, including 40 non‐Finnish European cases in the pilot study. Chi‐square tests were performed for case–control analysis against the 1000 genomes project as the control. A replication study of 44 DIALF cases that included 24 non‐Finnish Europeans was conducted to validate candidate variants. The association between clinical phenotype and genotypes was analysed using one‐way analysis of variance.ResultsEight variants (rs561037, rs561042, rs608339, rs655260, rs1142886, rs1142888, rs1142889 and rs1142890) in the guanylate binding protein 4 (GBP4) were significantly associated with DIALF in non‐Finnish Europeans in the pilot study and confirmed in the replication study. Rs561037 and rs561042 were highly significant with the lowest allele frequencies in both pilot and replication studies. An association was also found between these variants and milder clinical outcomes, indicated by lower peak levels of ALT, AST and higher Karnofsky performance scores.ConclusionOur study identified eight GBP4 missense variants linked to a lower risk of DIALF in the non‐Finnish European population. The GBP4 protein, activated by interferon‐gamma, plays a critical role in innate immunity. These findings suggest that GBP4 variants might influence immune and inflammatory responses in DIALF, though further studies are needed to elucidate the underlying mechanisms.