bluuebunny/crossref_metadata_2025_split huggingface dataset:
Molecular basis of neurodegeneration in a mouse model ofPolr3-related disease
Authors: Moir Robyn D. , Merheb Emilio , Chitu Violeta , Stanley E. Richard , Willis Ian M. 
Published: December 2023

AbstractPathogenic variants in subunits of RNA polymerase (Pol) III cause a spectrum ofPolr3-related neurodegenerative diseases including 4H leukodystrophy. Disease onset occurs from infancy to early adulthood and is associated with a variable range and severity of neurological and non-neurological features. The molecular basis ofPolr3-related disease pathogenesis is unknown. We developed a postnatal whole-body mouse model expressing pathogenicPolr3amutations to examine the molecular mechanisms by which reduced Pol III transcription results primarily in central nervous system phenotypes.Polr3amutant mice exhibit behavioral deficits, cerebral pathology and exocrine pancreatic atrophy. Transcriptome and immunohistochemistry analyses of cerebra during disease progression show a reduction in most Pol III transcripts, induction of innate immune and integrated stress responses and cell type-specific gene expression changes reflecting neuron and oligodendrocyte loss and microglial activation. Earlier in the disease when integrated stress and innate immune responses are minimally induced, mature tRNA sequencing revealed a global reduction in tRNA levels and an altered tRNA profile but no changes in other Pol III transcripts. Thus, changes in the size and/or composition of the tRNA pool have a causal role in disease initiation. Our findings reveal different tissue- and brain region-specific sensitivities to a defect in Pol III transcription.
A high-fidelity CRISPR-Cas13 system improves abnormalities associated with C9ORF72-linked ALS/FTD
Authors: McCallister Tristan X. , Lim Colin K. W. , Terpstra William M. , Zeballos C M. Alejandra , Zhang Sijia , Powell Jackson E. , Gaj Thomas 
Published: December 2023

ABSTRACTAn abnormal expansion of a GGGGCC hexanucleotide repeat in the C9ORF72 gene is the most common genetic cause of amyotrophic lateral sclerosis (ALS) and frontotemporal dementia (FTD), two debilitating neurodegenerative disorders driven in part by gain-of-function mechanisms involving transcribed forms of the repeat expansion. By utilizing a Cas13 variant with reduced collateral effects, we developed a high-fidelity RNA-targeting CRISPR-based system for C9ORF72-linked ALS/FTD. When delivered to the brain of a transgenic rodent model, this Cas13-based platform effectively curbed the expression of the GGGGCC repeat-containing RNA without affecting normal C9ORF72 levels, which in turn decreased the formation of RNA foci and reversed transcriptional deficits. This high-fidelity Cas13 variant possessed improved transcriptome-wide specificity compared to its native form and mediated efficient targeting in motor neuron-like cells derived from a patient with ALS. Our results lay the foundation for the implementation of RNA-targeting CRISPR technologies for C9ORF72-linked ALS/FTD.
The impact of new energy vehicle information sources on mass consumers' purchase intentions: an investigation in China
Authors: Xiong Yongqing , Cheng Qian , Xiong Yukang , Liao Mingyan 
Published: December 2023

PurposeThis study aims to investigate the impact and mechanism of new energy vehicle (NEV) information sources (IS) on mass consumers' purchase intentions (PIs) in China.Design/methodology/approachAround 902 valid questionnaires were collected using the questionnaire to analyze the different effects of three types of IS (official, interpersonal and commercial) on mass consumers' PIs. Besides, this study investigates the mechanisms by examining the mediating effect of perceived risk (PR) and the moderating effect of individual differences like age and education level.FindingsThe three types of NEV IS stimulate the PI of mass consumers, but there are some differences, with interpersonal information sources (IISs) having the strongest contribution, followed by official information sources (OISs) and commercial information sources (CISs) the least. Meanwhile, PR plays a mediating role in the effect of NEV IS on mass consumers' PIs, and age and education level moderate the influence paths. Specifically, the moderating effect of age mainly works on the negative impact of PR on PI, while education level moderates the influence of IS on PR.Originality/valueThis study contributes to filling the gaps in the current understanding of the role played by NEV IS in shaping consumer preferences and choices. It provides valuable insights for automotive manufacturers, policymakers and marketers to tailor their marketing strategies and improve information dissemination to effectively promote NEV adoption among mass consumers.
UK higher education staff's mental health and wellbeing during Covid-19
Authors: Kassem Rasha , Mitsakis Fotios 
Published: December 2023

PurposeThis paper examines the impact of the COVID-19 pandemic on the mental health and wellbeing of academic and professional Higher Education (HE) staff in the UK.Design/methodology/approachA mixed-method survey questionnaire was sent to almost 300 UK HE staff to secure qualitative and quantitative data to enable data triangulation.FindingsThe study found an adverse impact on academic and professional staff's mental health and wellbeing, further resulting in stress and anxiety. Several reasons for the increased stress and anxiety levels were identified, but social isolation and the increased workload were the most commonly reported. The most affected groups by the pandemic were females, younger staff, full-timers and those with disabilities or caring responsibilities.Practical implicationsThis study offers a range of strategies to support staff's mental health and wellbeing; as such, it is of great interest to policymakers to inform their decisions of similar crisis events in the future. It also addresses some of the COVID-19 areas of research interest for the UK parliament.Originality/valueThe study's originality derives from exploring the pandemic's impact on UK HE staff's mental health and wellbeing by including professional staff's experiences alongside those of academics. It also expands the scant evidence concerning the pandemic's impact on HE staff in the UK.
Unravelling the mysteries of cyber incivility: a systematic review and research agenda
Authors: Shahwar Durrey , Dhar Rajib Lochan 
Published: December 2023

Purpose
The current digital work environment promoting a “constant-on” culture is a hotbed for cyber incivility. Thus, there is a pressing need to understand its mechanisms. This study aims to shed light on the triggers, sources and impact of rude behaviours in cyberspace. The authors also present the boundary conditions that exacerbate or alleviate the effects of such negative experiences.

Design/methodology/approach
Through a systematic literature review based on predefined search protocols, the authors synthesised the current knowledge on cyber incivility and identified 21 peer-reviewed research articles.

Findings
The findings reveal the different sources of cyber incivility, its personal, relational and organisational antecedents and consequences, and its personal and situational boundary conditions that curb or enhance the negative impact.

Research limitations/implications
The authors unravel the main future research avenues based on the review findings by systemising knowledge on cyber incivility. Managerial efforts in the form of interventions and mitigation are also discussed to help combat this grieving issue in the workplace.

Originality/value
This paper presents the first systematic review of the cyber incivility literature and identifies new avenues for future research. Scholars can expand upon the findings of this study to fill gaps and move the incivility in cyberspace forward. It also offers practical insights on mitigating the advancement of such behaviours in organisations.
Cognitive styles and dynamic managerial capabilities: implications for SMEs in a transition economy
Authors: Kryeziu Liridon , Kurutkan Mehmet Nurullah , Krasniqi Besnik A. , Ramadani Veland , Hajrullahu Vjose , Haziri Artan 
Published: December 2023

PurposeThe dynamism of competition in international markets requires managers to react accordingly and ensure the firm's survival and competitiveness. This study examines the impact of cognitive styles and dynamic managerial capabilities (DMC) on a firm's international performance and the mediating role of these capabilities in the relationship between cognitive styles and international performance.Design/methodology/approachThis study adopts a quantitative cross-sectional research design, employing a sample of 306 firm owner-managers from exporting companies in Kosovo.FindingsThe findings suggest that managers' cognitive styles positively influence firm international performance, including their impact on DMC. Results also indicate that only managerial cognition mediates cognitive styles' effects on a firm's international performance, compared to managers' social capital.Originality/valueIn this study, the authors contribute to the literature by integrating cognitive styles with DMC in a transition country. Moreover, the authors demonstrate that DMC mediate the impact of cognitive styles on the firm international performance.
Intersectionality of place and race: entrepreneurial performance of Arab citizens of Israel
Authors: Said Inas Saleh , Vyas Vijay 
Published: December 2023

PurposeThe objective of this study is to understand how Arab entrepreneurs in Israel redress the disadvantage of the intersectionality of place and race by setting up their businesses in markets beyond their ethnic enclaves as well as by pursuing opportunity entrepreneurship and the role human values play in this process.Design/methodology/approachUsing the portrait value questionnaire, a survey of Arab entrepreneurs in Israel was conducted. Multiple linear regressions were run to generate the findings.FindingsThe authors find that educated and non-conforming Arab men in Israel, driven by stimulation and universalism, successfully neutralise the intersectional disadvantage of place and race through entrepreneurship.Research limitations/implicationsCare is advised in the generalisation of findings of this research to other intersectional communities as they emerge from the unique context of Arab entrepreneurs in Israel.Practical implicationsEducation, stimulation and universalism facilitate entrepreneurial success beyond Arab ethnic enclaves whereas conformity suppresses it.Social implicationsWith the right attributes and values, marginalised individuals can emerge from the disadvantage of the intersectionality of place and race.Originality/valueThe study advances the intersectionality discourse from “what it is” and “what it does” to “what can be done about it”. It identifies the attributes and values that help Arab entrepreneurs in Israel to remedy their intersectional disadvantage.
Back to goodwill amortisation: impact of the 2016 Spanish regulation on the mispricing of listed firms
Authors: Ruiz-Lamas Fernando , Peón David 
Published: December 2023

PurposeThis article analyses the recent inverse transition from goodwill impairment to goodwill amortisation implemented in Spain in 2016. The authors contribute to the existing literature by describing their differing impact over goodwill and impairment figures and testing the impact of goodwill on balances over stock prices.Design/methodology/approachFirst, using a database with all Spanish non-financial firms with positive goodwill on their balance sheets, the authors describe the impact of the regulatory change over goodwill and impairment figures. Second, focussing on listed firms only, the authors study the impact of financial reporting of goodwill and impairment on stock prices.FindingsAverage goodwill per company and the share of goodwill over total assets significantly reduced after 2016, but the results cannot be easily extrapolated to listed firms due to lack of data. When testing the impact of potentially inflated goodwill balances on prices, the authors find that investors kept overvaluing firms with inflated goodwill balances also with the amortisation method.Research limitations/implicationsThe lack of data for listed firms with goodwill in Spain makes it difficult to obtain statistically sound evidence, the results could be biased by the cultural traits of the country and related to the intensity of enforcement and monitoring.Practical implicationsThis might suggest that the effects of the impairment method linger, so the authors conform to the interpretation that the systematic amortisation paired with a periodic impairment test may lead to accounting that better reflects the underlying economics of goodwill.Originality/valueTo the best of the authors' knowledge, there are no recent articles that analyse this new “turn-around” requiring again the systematic amortisation of goodwill.
The effectiveness of influencer endorsements for smart technology products: the role of follower number, expertise domain and trust propensity
Authors: Kim Taeyeon , Yoon Hye Jin 
Published: December 2023

Purpose
Considering the growth of the at-home smart technology industry and the increasing power of social media influencers, this study aims to examine how influencer endorsements affect individuals’ attitudes and trial intentions toward smart technology products.

Design/methodology/approach
An online experiment was conducted to investigate the impact of follower number and expertise domain of influencers and the trust propensity of individuals on their attitudinal and behavioral responses to influencer endorsements of smart technology products. The moderated mediation effect of perceived credibility was further examined.

Findings
The results demonstrated that individuals with lower trust propensity responded more positively to a microinfluencer with fewer followers and a specific area of expertise, which led to favorable attitudes and increased intention to try a smart technology product. However, the expertise domain was not a significant factor for the megainfluencer condition with a more extensive follower base. Interestingly, the interaction effects were not observed for individuals with higher trust propensity.

Practical implications
The results of this research provide practical implications for marketers who look for effective strategies for influencer marketing by demonstrating the significant impact of source-related cues, including follower number and expertise domain.

Originality/value
Based on the modality, agency, interactivity and navigability; source credibility; and persuasion knowledge models, this research explains how source-related cues of influencers affect credibility judgment, attitude formation and trial intentions for new technology products and how trust propensity as a personal dispositional factor varies the relationship.
Does the verified badge of social media matter? The perspective of trust transfer theory
Authors: Liao Chien Hsiang , Hsieh Jung-Kuei , Kumar Sushant 
Published: December 2023

PurposeOn Instagram, a verified badge (a blue checkmark) is used to confirm the authenticity of influencers' accounts for consumers. Yet, it is unclear whether followers trust the badge or are influenced by the influencer's large following. This research aims to investigate the impact of verified badges on followers' trust and behavioral intentions.Design/methodology/approachThis research conducts three experiments to investigate the impact of the verified badge on consumer attitudes and behavioral intentions, recruiting participants from freelance recruiting website in all three experiments.FindingsThe results show that a verified badge can sequentially influence consumer trust, attitude and sharing intentions. Furthermore, the impact of the verified badge on trust is more pronounced among micro-influencers as opposed to macro-influencers, and it can mitigate the negative attitude toward commercial postings.Originality/valueBased on trust transfer theory, this research is a pioneer in investigating the effectiveness of verified badges on social media. These findings contribute to the field of influencer marketing by considering influencers' characteristics and the commercial intent of postings as moderators. Additionally, the results offer managerial insights for developing influencer marketing strategies.
How to transform brand haters into forgivers through emotional intelligence?
Authors: Mednini Latifa , Damak Turki Mouna 
Published: December 2023

PurposeConsumers' responses to service failures are influenced not just by company-related issues but also by one's ability to react to stressful situations. The aim of this research is to explore the emotional intelligence of brand haters and transform them into forgivers.Design/methodology/approachThis study used two qualitative methods, namely in-depth semi-structured interviews with a total of 17 participants who have different emotional intelligence levels (high, medium and low) and projective techniques with 6 participants.FindingsThis study's results showed that consumers with high and medium emotional intelligence feel less hate toward a brand and are more likely to forgive it, whereas consumers with low emotional intelligence feel more hate toward a brand and are unwilling to forgive it.Originality/valueTo the best of the authors' knowledge, this study is among the first to shed light on the importance of managing hate by consumers. Findings will help managers understand the importance of consumer personality in a management strategy and explain why some consumers forgive brands while others participate in anti-brand activities.
Food security for Nigerians through sustainable agriculture
Authors: Garba Khalid 
Published: December 2023

PurposeThe purpose of this paper is to develop a practical implementation blueprint for the attainment of food security for all Nigerians based on sustainable agricultural practices.Design/methodology/approachThis paper conducted a critical review of 66 peer-reviewed empirical articles on various sustainable agricultural case studies. The evidence obtained from this review and the in-depth knowledge of the authors regarding the Nigerian agricultural landscape was used to develop a practical implementation blueprint for achieving food security in the country.FindingsThe food security for all Nigerians (FOSFAN) blueprint was developed and comprising of eight practical and interconnected steps. These steps take into consideration the synergistic effort of the government, the ministry of agriculture and its corresponding agencies in ensuring that farmers attain sustainable practices in their endeavour.Research limitations/implicationsThe findings of this paper will contribute to existing literature on food security and will also serve as a baseline for deeper empirical exploration of the impact of sustainable agricultural practices on food security in Nigeria (a country in the Sub-Saharan region).Practical implicationsThe FOSFAN blueprint provides a practical and comprehensive step-by-step guide, which the Nigerian Ministry of Agriculture can use to achieve food security for all Nigerians.Social implicationsThis paper is addressed towards the development of food security plan in the Nigerian context in which the Nigerian Government ensures the availability of food to all its citizens in a bid to achieve “Zero Hunger”, which is the second Sustainable Development Goal.Originality/valueThe FOSFAN blueprint is a proactive guide that takes into consideration the importance of cultural and socioeconomic nuances in the development of a sustainable agriculture policy in a developing country context.
Lignosulfonate and glycidyl ether modified urea formaldehyde wood adhesives for interior particleboard production
Authors: Alkan Ümran Burcu , Kızılcan Nilgün , Bengü Başak 
Published: December 2023

Purpose
The purpose of this study is the development of sustainable and low-formaldehyde emission wood adhesive formulations.

Design/methodology/approach
Three-step urea formaldehyde (UF) resin has been in situ modified with calcium lignosulfonate (LS) and/or 1,4 butanediol diglycidyl ether (GE). The structural, chemical, thermal and morphological characterizations were carried out on resin samples. These resins have been applied for particleboard pressing, and UF, UF-LS and UF-GE were evaluated as P2 classes according to EN 312.

Findings
The results show that the improved LS- or diglycidyl ether-modified UF wood adhesives were successful in their adhesive capacity, and the formaldehyde content of the final product was obtained as low as 8 mg/100 g. This paper highlights that the presented adhesive formulations could be a potential eco-friendly and cost-effective alternative to formaldehyde-based wood adhesives for interior particleboard production.

Research limitations/implications
Combination of LS and GE resulted in weaker mechanical properties and fulfilled P1 class particleboards due to temperature and duration conditions. Therefore, in situ usage of LS or GE in UF resins is highly recommended for particleboard pressing. Formaldehyde content of particleboards was determined with the perforator method according to EN 12460-5 and all of the particleboards exhibited E1 class. LS was more efficient in decreasing formaldehyde content than GE.

Practical implications
This study provides the application of particleboards with low formaldehyde emission.

Social implications
The developed LS- and diglycidyl ether-modified UF resins made it possible to obtain boards with significantly low formaldehyde content compared with commercial resins.

Originality/value
The developed formaldehyde-based resin formulation made it possible to produce laboratory-scale board prototypes using LS or GE without sacrificing of press factors and panel quality.
Measuring the degree of connection between currency futures: Empirical dive into higher moments
Authors: Donduran Murat , Faisal Muhammad Ali 
Published: December 2023

Purpose
The purpose of this study is to unfold the existing information channel in the higher moments of currency futures for different time horizons.

Design/methodology/approach
The authors use a quasi-Bayesian local likelihood approach within a time-varying parameter vector autoregression (TVP-VAR) framework and a dynamic connectedness measure to study the volatility, skewness and kurtosis of most traded currency futures.

Findings
The authors’ results suggest a time-varying presence of dynamic connectedness within higher moments of currency futures. Most spillovers pertain to shorter time horizons. The authors find that in net terms, CHF, EUR and JPY are the most important contributors to the system, while the authors emphasize that the role of being a transmitter or a receiver varies for pairwise interactions and time windows.

Originality/value
To the best of the authors’ knowledge, this is the first study that looks upon the connectivity vis-á-vis uncertainty, asymmetry and fat tails in currency futures within a dynamic Bayesian paradigm. The authors extend the current literature by proposing new insights into asset distributions.