bluuebunny/crossref_metadata_2025_split huggingface dataset:
Effectiveness and Safety After a Switch to Tildrakizumab: A Real World Multicenter Italian Study in Psoriasis
Authors: Di Brizzi Eugenia Veronica , Buononato Dario , Benvenuto Pierfrancesco , Argenziano Giuseppe , De Pasquale Rocco , Fiorella Carmen Silvia , Gioffrè Claudia , Musumeci Maria Letizia , Palazzo Giovanni , Zichichi Leonardo , Balato Anna 
Published: November 2023

Introduction: Tildrakizumab is a humanized IgG1κ monoclonal antibody targeting the p19 subunit of interleukin (IL)-23, approved in 2018 for the treatment of patients with moderate-to-severe chronic plaque psoriasis.
Objectives: This study aimed to evaluate the effectiveness, safety and survival of tildrakizumab in the medium term (48 weeks) in psoriatic patients failure to previous biologic treatment in a real world setting.
Methods: This was a retrospective, multicenter observational study that included adult patients with moderate-to-severe plaque psoriasis, failure to previous biologic therapy, consecutively treated with tildrakizumab. PASI and BSA values were recorded at baseline, at 12 and 48 weeks of treatment. Safety and tolerability of tildrakizumab were investigated by examining the presence of any adverse events.
Results: Overall 51 patients were enrolled. Baseline disease severity was moderate to severe with a mean PASI score of 19.2 ± 8.5, mean BSA of 16 ± 10.4, and mean DLQI of 18.2 ± 6.8. A significant reduction in the mean PASI score was detected at 12 weeks of tildrakizumab therapy (3.5 ± 2.7, p < 0.001), with a further improvement at week 48 (0.6 ± 1.5, p < 0.001). At week 12, there was a great improvement in BSA score for all groups (p <0.001) with further increase at week 48. The effectiveness was confirmed also by DLQI assessment, with a significant decrease at week 12 and even more at week 48 (p <0.001).
Conclusions: This study confirms the effectiveness of tildrakizumab in daily clinical practice in patients with moderate-to-severe plaque psoriasis.
Existence and uniqueness of weak solutions to parabolic problems with nonstandard growth and cross diffusion
Authors: Arumugam Gurusamy , Erhardt Andre H. 
Published: November 2023

We establish the existence and uniqueness of weak solutions to the parabolic system with nonstandard growth condition and cross diffusion, $$\displaylines{ \partial_tu-\text{div}a(x,t,\nabla u)) =\text{div}|F|^{p(x,t)-2}F),\cr \partial_tv-\text{div}a(x,t,\nabla v))=\delta\Delta u, }$$ where \(\delta\ge0\) and \(\partial_tu,~\partial_tv\) denote the partial derivative of u and v with respect to the time variable t, while \(\nabla u\) and \(\nabla v\) denote the one with respect to the spatial variable x. Moreover, the vector field \(a(x,t,\cdot)\) satisfies certain nonstandard p(x,t) growth, monotonicity and coercivity conditions.
For more information see https://ejde.math.txstate.edu/Volumes/2020/123/abstr.html
Global solutions for fractional viscoelastic equations with logarithmic nonlinearities
Authors: Cabanillas Lapa Eugenio 
Published: November 2023

In this article we study a fractional viscoelastic equation of Kirchhoff type with logarithmic nonlinearities. Under suitable conditions we prove the existence of global solutions and the exponential decay of the energy.
For more information see https://ejde.math.txstate.edu/Volumes/2020/125/abstr.html
Solidarity-Based Content Sharing on Social Media: A Closer Look at the Language Style among Millennial Social Platform Users
Authors: Saragih Mandra , Aisyaroh Yola Ayudi 
Published: November 2023

Social Media platforms have shaped diverse linguistic issues through informal language use, language adaptation and change, linguistic creativity and global communication. The current study reveals the issues about investigating about language style and linguistic form of solidarity expression used by the millennial community on social media platforms. Thirty respondents who aged about 23-43 years old considered as millennial participated in this study and inquired through open-ended questionnaire. The data was probed by using grounded theory proposed by Creswell. The findings exposed that language style were realized for certain communication purposes and based-social context oriented, solidarity expression was shown through a different linguistic form to reveal ideas, feeling, empathy, caring, respect, moral justice and kinds of arguments. after deeply investigated, there were four types of language styles that are dominantly used by millennial on this social media platform, namely formal language style, informal language style, slang language style and colloquial language style, unfortunately, many people abuse social media as a platform for venting their anger and their disappointment by using disrespectful language and behaviors are frequently observed online. Consequently, this scholarly paper also provides advice on the user of social media platform must possess a range of skills including linguistic knowledge, sociocultural knowledge, and the ability to use language in appropriate ways depending on the specific communicative context.
Educational Supervision: An Analysis of Models, Approaches, And Techniques of Educational Supervision in Higher Education
Authors: Nur Rochbani Ita Tryas , Nurdianingsih Fitri 
Published: November 2023

This research aims to conduct research by applying descriptive analysis techniques using library research. Testing the validity of the data was carried out by triangulating the data from references, both in terms of method and in terms of sources.
The results of this research indicate that the implementation of educational supervision should not only be carried out by lecturers but also apply to the entire academic community, including education staff. The involvement of all components of the academic community through various models, approaches and techniques of educational supervision by lecturers, rectors, education staff, foundations, students, the community and government is very necessary for the progress of a higher education institution.
CHARACTERISTICS OF ORIENTALISM STUDIES AND IMPLICATIONS FOR THE ISLAMIC WORLD
Authors: Sapariah Jamiatun , Rezky Laily , Ajmi Syauhan , Abdul Aziz Abdul Rashid 
Published: November 2023

This study aims to analyze the study of orientalism through a qualitative approach to literature study, which will be observed based on several indicators, namely in terms of understanding, characteristics, and implications for the Islamic world. Initially, Orientalism was understood as an understanding carried out by Westerners to explore the East, both in terms of religion and civilization. The study of Orientalism has a strong relationship with Western colonialism in the Eastern world, colonialism, imperialism, missionarism and Christianization movements. In its development, orientalism gave another color through the emergence of controversial things circulating about Islam such as damaging the <em>real</em> image of Islam, opportunities to enrich Islamic studies and introduce the original face of Islam <em>rahmatan lilalamin</em>, joy for the western world that began to recognize Islamic civilization, its contribution in the field of translation as well as Eastern scholarship, and encouragement in efforts to achieve peace. With this study we can also understand not always negative orientalists, but there are also those who purely as academics make themselves objective researchers. So that thefaith of Muslims in orientalism should not be shown through emotions, and diversity of judgments of Islam also exists. However, there is nothing wrong with staying vigilant and caring for aqidah by increasing faith in Allah SWT and making this motivation through the need for intention and deepening <em>shahih </em> knowledge, especially in the current era
Social Protection for Indonesian Domestic Workers in Taiwan
Authors: Reza Yusup Muhammad 
Published: November 2023

When working overseas, domestic workers are susceptible to a variety of risks that can compromise their level of living. These risks encompass a variety of types, including health and work accidents. Social protection is a form of action or policy that is present to counteract this. Nonetheless, the activities of domestic workers who work abroad cause the social protection that is applied to them is not only from one side, namely the country of origin or the country of destination, but also both. The purpose of this paper is to examine various types of social protection for Indonesian domestic workers in Taiwan. This paper analyzes the experiences and knowledge of five informants who have or are now employed as domestic workers in Taiwan by interviewing them about their access to or utilization of the various social protection programs available to them. The discussion of their experiences is separated into two types of social protection: formal, provided by the governments of Indonesia as well as the government of Taiwan, and informal. The findings of this paper indicate that, on the one hand, the informants do not share the same awareness of the existence of social protection provided by the Indonesian government and, on the other hand, they are aware of and have utilized the health insurance provided by the Taiwanese government, although they do not share the same understanding of other insurances, such as the work accident insurance provided under the employment contract. Moreover, donations and training provided by non-government agencies are identifiable informal social protection in this study. This paper also argues that the awareness of Indonesian domestic workers about the importance of social protection can be improved by providing socialization regarding awareness of their future potential risks.
Chest Physiotherapy to Manage Respiratory Rate In Patients with Bronchopneumonia: A Literature Review
Authors: Bisma Yudha Magenda , Wardoyo Eko 
Published: November 2023

Purpose: Knowing the application of chest physiotherapy techniques can manage respiratory rates in children with bronchopneumonia. Methods: This review uses the literature review method. Searches were conducted in PubMed, Garuda, and Google Scholar. The search strategy used keywords with "bronchopneumonia", "chest", "physiotherapy", "respiratory rate". Findings: There were eight articles reviewed in this literature review. Seven articles discussed the application of chest physiotherapy and one article discussed the combination of nebulization therapy and chest physiotherapy in bronchopneumonia or pneumonia patients in children. The overall results of this review show that the application of chest physiotherapy in airway clearance problems in children with bronchopneumonia or pneumonia is effective in removing sputum, diluting sputum, and stabilizing hemodynamic status. Conclusions: The application of chest physiotherapy in children with bronchopneumonia or pneumonia has been shown to stabilize hemodynamic status such as pulse frequency, respiratory rate frequency, oxygen saturation within normal limits, and can remove secretions, sputum, and reduce cough frequency.
The Correlation between Motivation and Anesthetists’ Working Performance in Banyumas Regency
Authors: Achmad Fadilah Rizal , Sukmaningtyas Wilis , Burhan Asmat 
Published: November 2023

Background: The performance of health workers is a very crucial issue to be studied in order to maintain and improve health services. The impact that occurs if the performance of health workers in the hospital is not good can cause patients and families to feel dissatisfied, patients and families will not use health services again. One of the factors that affect performance is motivation. Objective: Knowing the relationship between motivation and the performance of anesthesiologists in the Banyumas Regency area. Research: The research method is correlation analytics research with a cross sectional approach. The sampling technique used total sampling, a total of thirty-nine respondents. Data collection using work motivation and performance questionnaires. Bivariate analysis using spearman-rank. Results: The results of the study obtained a percentage of 39 respondents of anesthesiologists in the Banyumas Regency area with sufficient motivation as many as 28 respondents (71.79%) and respondents who had sufficient performance as many as 31 respondents (79.98%). The results of spearman-rank analysis showed a significant relationship, work motivation with the performance of anesthesiologists with a correlation value of 0.733 and a 2-tailed sig of 0.000. Conclusion: Advice for the anesthesiologist profession who is especially incorporated in the organization at the DPC IPAI Banyumas Branch Secretariat which researchers recommend is expected to improve the quality and quantity of health services to patients and families, namely by carrying out predetermined procedures and friendly, so that patients and families feel comfortable and served with satisfaction for the services provided.
The Relationship between Hypertension and Anxiety Level in the Elderly in Mandungan Srimatani Sub-district Piyungan Bantul Regency Yogyakarta
Authors: Isnaeni Yeni , Nur Adkhana Sari Dian , Nur Hartiningsih Sri 
Published: November 2023

ABSTRACT

Background: Hypertension is still a problem for the elderly, the changes experienced by the elderly will experience a lot of decline, both physically, mentally, and socially. As an age that shows the aging process, this condition makes high blood pressure a health problem for the elderly. A person is said to have hypertension and has a systolic and diastolic blood pressure of 140/90 mmHg. Hypertension is often found in the elderly, the physical limitations experienced by the elderly will experience anxiety because the various diseases they suffer do not go away and even get worse in the end they experience psychological disorders, namely anxiety, which is marked by deep and ongoing fears and worries.
Objective: To determine the relationship between hypertension and anxiety levels in the elderly in Mandungan Srimartani Hamlet, Piyungan District, Bantul Regency, Yogyakarta.
Methods: This research is non-experimental with a correlation study using a cross sectional approach, and the sample size is 39 respondents aged 60-80 years.
Results: The data that has been analyzed using the Kendall-Tau test has a correlation coefficient value of 0.483** and a significant value of 0.001 < 0.005.
Conclusion: There is a relationship between hypertension and anxiety levels in Mandungan Srimartani Hamlet, Piyungan District, Bantul Regency, Yogyakarta.

Keywords: Hypertension, Anxiety Level, Elderly
A benzochalcone derivative synchronously induces apoptosis and ferroptosis in pancreatic cancer cells
Authors: Guan Xiaoqing , Zhao Bing , Guan Xiaodan , Dong Jinyun , Ying Jieer 
Published: November 2023

Background
Pancreatic cancer is a highly aggressive and lethal disease with limited treatment options. In this study, we investigated the potential therapeutic effects of compound KL-6 on pancreatic cancer cells.

Methods
The study involved assessing the inhibitory effects of KL-6 on cell proliferation, clonogenic potential, cell cycle progression, apoptosis, migration, and invasion. Additionally, we examined the action mechanism of KL-6 by RNA-seq and bioinformatic analysis and validated by qRT-PCR and western blot in pancreatic cancer cells.

Results
Our results demonstrated that KL-6 effectively inhibited the growth of pancreatic cancer cells in a dose-dependent manner. It induced G2/M phase cell cycle arrest and apoptosis, disrupting the cell cycle progression and promoting cell death. KL-6 also exhibited inhibitory effects on cell migration and invasion, suggesting its potential to suppress the metastatic properties of pancreatic cancer cells. Furthermore, KL-6 modulated the expression of genes involved in various cancer-related pathways including apoptosis and ferroptosis.

Conclusion
These findings collectively support the potential of KL-6 as a promising therapeutic option for pancreatic cancer treatment. Further research is needed to fully understand the underlying mechanisms and evaluate the clinical efficacy of KL-6 in pancreatic cancer patients.
Performance Evaluation of Olorunsogo Gas-Fired Power Plant Phase I
Authors: Eko, Michael A.  , Ale, Thomas O.  
Published: November 2023

Aim: The aim of this research is to evaluate the performance of the Olorunsogo gas-fired power plant phase 1, examines the reason(s) for not operating at full capacity, and proffers possible solution(s).
Study of the Design: The power plant comprises of eight (8) numbers of 42MW unit gas turbine capable of evacuating 277MW.
Methodology: To obtain electrical parameters from the gas turbine, a mathematical model for pressure using a simple open-cycle gas turbine was developed. The pressure was further converted to energy using principles of kinetic theory of gases. Hence, the efficiency and other performance indicators were calculated.
Results: The study revealed an average operating capacity of 31.28MW. The average efficiency of the power plant in the period under review was 50.88%, as compared to the international standard practice of 65% and above. The average load factor and capacity factor was 11.25% and 11.54% respectively as compared to international standard practice of 50-80%, while the average reliability was 55.79%, as compared to international standard practice of 95%.
Conclusion: The study further reveals that wastage of gas, downtime, and inadequate gas supply are the major factors against the full capacity operation of the power plant. The proffered possible solutions articulated in this study if implemented, will optimize the power plant's full-capacity operation.
Hidden Infrastructures: From ‘Spy‐Hubs’ to Hollow Buildings that Conceal the New Digital
Authors: Fok Wendy W 
Published: November 2023

AbstractThere are many examples of large technological infrastructure insinuating its unsightly or bland but big manifestations in our cities, and clandestinely covering itself in deceitful architectural details and typologies. Architect and academic Wendy W Fok co‐led the collaborative Hidden Infrastuctures project, which reveals these tactics, used by both data and extraction technologies, to illustrate a world of subterfuge where all is not what it seems.
All At Once – From Zoom Fatigue to Immersive Digital Experiences: Why Architecture Must Adapt
Authors: Belitskaja Sasha 
Published: November 2023

AbstractThe constellation of digital techniques, software, visual and haptic prosthetics is growing exponentially by the day. Such innovations allow all manner of choreographed synthesis between the world we see, unaugmented, and the world we experience through our devices. With her practice iheartblob, Sasha Belitskaja makes Surrealist architectonic interventions and installations that straddle the virtual/ actual divide, using the best of both worlds.
Dipicolylamine‐Zn Induced Targeting and Photo‐Eliminating of Pseudomonas aeruginosa and Drug‐Resistance Gram‐Positive Bacteria
Authors: Wang Zuokai , Cai Wenlin , Ning Fangrui , Sun Wen , Du Jianjun , Long Saran , Fan Jiangli , Chen Xiaoqiang , Peng Xiaojun 
Published: November 2023

AbstractThe emergence of drug‐resistant bacteria, particularly resistant strains of Gram‐negative bacteria, such as Pseudomonas aeruginosa, poses a significant threat to public health. Although antibacterial photodynamic therapy (APDT) is a promising strategy for combating drug‐resistant bacteria, actively targeted photosensitizers (PSs) remain unknown. In this study, a PS based on dipicolylamine (DPA), known as WZK‐DPA‐Zn, is designed for the selective identification of P. aeruginosa and drug‐resistant Gram‐positive bacteria. WZK‐DPA‐Zn exploits the synergistic effects of DPA‐Zn2+ coordination and cellular uptake, which could effectively anchor P. aeruginosa within a brief period (10 min) without interference from other Gram‐negative bacteria. Simultaneously, the cationic nature of WZK‐DPA‐Zn enhances its interaction with Gram‐positive bacteria via electrostatic forces. Compared to traditional clinical antibiotics, WZK‐DPA‐Zn shows exceptional antibacterial activity without inducing drug resistance. This effectiveness is achieved using the APDT strategy when irradiated with white light or sunlight. The combination of WZK‐DPA‐Zn with Pluronic‐based thermosensitive hydrogel dressings (WZK‐DPA‐Zn@Gel) effectively eliminates mixed bacterial infections and accelerates wound healing, thereby achieving a synergistic effect where “1+1>2.” In summary, this study proposes a precise strategy employing DPA‐Zn as the targeting moiety of a PS, facilitating the rapid elimination of P. aeruginosa and drug‐resistant Gram‐positive bacteria using APDT.
Copper‐Catalyzed Regioselective 1,4‐Phosphinoylcyanation of 1,3‐Enynes with Diarylphosphine Oxides and TMSCN
Authors: Lv Yunhe , Xie Jinhui , Pu Weiya , Wang Xue , Zhang Huanhuan , Li Xuerui , Liu Yan , Chen Fei , Xu Yunfeng 
Published: November 2023

AbstractWe established a strategy for the copper‐catalyzed three‐component 1,4‐phosphinoylcyanation of 1,3‐enynes with diarylphosphine oxides and trimethylsilyl cyanide. The reaction produced various tetrasubstituted phosphinoyl‐ and cyano‐containing allenes with high functional group compatibilities in good yields under mild reaction conditions. A preliminary reaction mechanism involving the formation of phosphinoyl radicals and their regioselective addition to 1,3‐enynes was also proposed.
Synthesis of Monofluorocyclohexene via Photocatalytic Defluorinative [4+2] Annulation of gem‐Difluoroalkenes with Unactivated Alkenes
Authors: Zhang Guang‐Xu , Li Dong‐Sheng , Xue Fei , Chen An‐Feng , Deng Hong‐Ping 
Published: November 2023

AbstractHerein, a photocatalytic system for defluorinative [4+2] annulation of gem‐difluoroalkenes with unactivated alkenes is realized. This protocol was compatible with a broad scope of unactivated alkenes, affording the diverse monofluorocyclohexene products in 30–95% yields. Furthermore, the value of this method was demonstrated by the gram‐scale synthesis, late‐stage functionalization and synthesis of various valuable and complex monofluorocyclohexene derivatives.
Cluster analysis and its application in teaching resources of university curriculum: A personalized method
Authors: Zhao Yingying , Zhao Chunxia , Wang Zhe , Min Zehao 
Published: November 2023

AbstractThe current personalized recommendation methods for teaching resources of university courses suffer from poor recommendation effectiveness due to the absence of user tags. To address this issue, a new personalized recommendation method based on cluster analysis is proposed. The proposed method leverages web crawler technology to obtain user tags, followed by processing the tags to remove meaningless terms, normalize word forms, and perform data processing. The processed tags are used to calculate user interest preferences for each tag cluster generated by clustering. Based on this, a user interest model is built, and user similarity is calculated to determine the recommendation score of each resource. The recommended resources are then ranked according to their recommendation score and presented to the target user. Experimental results demonstrate that the proposed method achieves high accuracy, recall rate, and F1 value for personalized recommendation of teaching resources in colleges and universities. In comparison, the method proposed in this paper has a significantly shorter recommendation time of 10.65 s. Further, the proposed model not only takes less time but also has higher recommendation efficiency when compared with existing personalized recommendation methods.