bluuebunny/crossref_metadata_2025_split huggingface dataset:
Androgen receptor study in children with hypospadias in comparison with children with normal genitalia
Authors: Nerli RB , Rai Shreyas , Sanikop Adarsh , Ghagane Shridhar 
Published: October 2023

Androgen receptors (ARs) have been localized to the penile skin, inner prepuce and urethra. Androgens play an important and vital role in the development of male urethra. Androgen signalling through the AR is critical for normal penile development. The objective of our study was to prospectively assess the AR staining score in children with hypospadias in comparison with children with normal genitalia. All children with hypospadias presenting to the Paediatric urological services for repair formed the study group. Children with normal genitalia and undergoing circumcision either for phimosis or for religious indications formed the controls. A piece of the foreskin was collected during surgery and were stained for immunohistochemistry. AR staining was expressed as an m-quick score. A total of 32 children (group I) underwent primary hypospadias repair and 24 children (group II) underwent circumcision during the study period. The mean m-quick score in patients with hypospadias was 219.96 and that of children undergoing circumcision was 90.04 (p &#60;0.050). AR is overexpressed in patients with hypospadias when compared with patients with normal genitalia. Similarly, AR is significantly overexpressed in patients with proximal hypospadias when compared with distal hypospadias.
Evaluation of image resolution and quantification parameters on fdg-pet/ct images in patients with metastatic breast cancer using Q. clear and osem reconstruction techniques
Authors: Dahal Tshetiz , Nepal Bimal 
Published: October 2023

We compared the 2-[18F]FDG-PET/CT scans performed for response monitoring in patients with metastatic breast cancer in a prospective setting using the ordered subset expectation maximization (OSEM) algorithm and the bayesian penalized likelihood reconstruction algorithm (Q.Clear) and the image quality and quantification parameters. 35 patients with metastatic breast cancer who were treated and followed up with 2-[18F]FDG-PET/CT were included. A total of 150 scans were evaluated on a five-point scale for the image quality parameters of noise, sharpness, contrast, diagnostic confidence, artefact, and blotchy look while being blinded to the Q.Clear and OSEM reconstruction algorithms. In scans with detectable disease, the lesion with the highest volume of interest was chosen, taking into account both reconstruction techniques' interest levels. For the same heated lesion, SULpeak (g/mL) and SUVmax (g/mL) were contrasted. The OSEM reconstruction had significantly less blotchy appearance than the Q.Clear reconstruction, while there was no significant difference between the two methods in terms of noise, diagnostic confidence, or artefact. Q.Clear had significantly better sharpness (p &#60; 0.002) and contrast (p &#60; 0.002) than the OSEM reconstruction. Quantitative examination of 75/150 scans revealed that Q.Clear reconstruction considerably outperformed OSEM reconstruction in terms of SULpeak (6.33 ± 1.8 vs. 5.85 ± 1.5, p &#60; 0.002) and SUVmax (7.27 ± 5.8 vs. 3.90 ± 2.8, p 0.002). In conclusion, OSEM reconstruction was less blotchy, but Q.Clear reconstruction showed superior sharpness, better contrast, higher SUVmax, and higher SULpeak.
A Pilot Observational Study Evaluating the Diagnostic Capacity of Rotational Thromboelastometry in Periprosthetic Joint Infections
Authors: Tsantes Andreas G. , Papadopoulos Dimitrios V. , Goumenos Stavros , Trikoupis Ioannis G. , Tsante Konstantina A. , Bellou Vanesa , Koulouvaris Panagiotis , Houhoula Dimitra , Kriebardis Anastasios , Piovani Daniele , Nikolopoulos Georgios K. , Mavrogenis Andreas F. , Papagelopoulos Panayiotis J. , Bonovas Stefanos , Tsantes Argirios E. 
Published: October 2023

Background:
Periprosthetic joint infections (PJIs) are associated with altered hemostatic dynamics; therefore, coagulation laboratory methods such as rotational thromboelastometry (ROTEM) may be valuable in their diagnosis. The aim of this study was to evaluate the diagnostic role of ROTEM in PJI.

Methods:
A diagnostic study was conducted including 65 patients who underwent revision total hip arthroplasty or total knee arthroplasty due to PJI (30 patients) or aseptic loosening (35 patients). Preoperative laboratory evaluation included conventional coagulation studies, inflammatory markers, and ROTEM analysis. These parameters were compared between patients with PJI and patients with aseptic loosening.

Results:
Several ROTEM parameters differed in the patients with PJI, indicating a higher coagulation potential associated with PJI. Specifically, the development of PJI was associated with higher EXTEM maximum clot firmness (MCF) (odds ratio [OR], 1.12 [95% confidence interval (CI), 1.04 to 1.20]; p = 0.001). Among the ROTEM parameters, EXTEM MCF was found to have the highest diagnostic accuracy for PJI (area under the receiver operating characteristic curve, 0.850; sensitivity, 76.6%; specificity, 91.4%), which was comparable with C-reactive protein (CRP) (p = 0.22) and erythrocyte sedimentation rate (ESR) (p = 0.65), but higher than D-dimer (p = 0.037). Moreover, the combined diagnostic accuracy of elevated EXTEM MCF and CRP was improved compared with CRP alone (p = 0.019).

Conclusions:
Our results indicate that ROTEM analysis might be helpful for the detection of the hemostatic derangements that are associated with the development of PJI. However, because of the small size of this pilot study, further research is needed to investigate the value of incorporating viscoelastic studies in diagnostic scores for PJI.

Level of Evidence:
Diagnostic Level III. See Instructions for Authors for a complete description of levels of evidence.
Implementasi Media Pembelajaran Crossword Puzzle Untuk Meningkatkan Keaktifan Peserta Didik Kelas IX.6 di SMP Negeri 57 Palembang
Authors: Saraswati Melly , Alfiandra  , Rita Murniati Sepertia 
Published: October 2023

Based on the results of observations in class IX.6 for the 2022/2023 academic year, it was found that students' less activity was indicated by not paying attention to the teacher in learning, a lack of interest in learning which caused teaching and learning activities in the class’s feel quiet. This study aims to increase the active learning of students in class. This type of research is classroom action research (PTK) with 3 cycles. The subjects were 30 students consist of 16 male students and 14 female students. Learning activities by applying crossword puzzle learning media. The results showed that the application of TGT type cooperative learning with crossword puzzle learning media had been carried out very well. The active learning of students obtained from the results of observations is in the high category with a percentage of 80.34% and has reached the research target. Based on the results of this study, it can be concluded that crossword puzzle learning media has proven effective in increasing student learning activity in class.
Berdasarkan hasil observasi di kelas IX.6 tahun ajaran 2022/2023 ditemukan bahwa kurang optimalnya keaktifan peserta didik ditandai dengan tidak memperhatikan guru dalam pembelajaran, kurangnya minat belajar yang menyebabkan kegiatan belajar mengajar di kelas terasa sunyi. Penelitian ini bertujuan untuk meningkatkan keaktifan belajar peserta didik di kelas. Jenis penelitian ini adalah penelitian tindakan kelas (PTK) dengan 3 siklus. Subjek penelitian adalah 30 orang peserta didik dengan jumlah 16 orang peserta didik laki-laki dan 14 orang peserta didik perempuan. Kegiatan pembelajaran dengan menerapkan media pembelajaran crossword puzzle. Hasil penelitian menunjukkan bahwa penerapan pembelajaran kooperatif tipe TGT dengan media pembelajaran crossword puzzle atau teka-teki silang (TTS) telah terlaksana dengan sangat baik. Keaktifan belajar peserta didik yang diperoleh dari hasil observasi berada pada kategori tinggi dengan persentase 80,34% dan telah mencapai target penelitian. Berdasarkan hasil penelitian tersebut, dapat disimpulkan bahwa media pembelajaran crossword puzzle atau teka-teki silang (TTS) terbukti efektif dalam meningkatkan keaktifan belajar peserta didik dalam kelas.
Synthesis of lanthanum and waste lye modified-zeolite from fly ash and its application in constructed wetland for nitrogen and phosphorus removal
Authors: Liu Zhimei , Liang Zhen , Wu Shengjun 
Published: October 2023

Abstract
Excess inputs of nitrogen (N) and phosphorus (P) can lead to imbalance in water ecosystems and thus trigger eutrophication. In this study, a novel Lanthanum modified zeolite synthesized from fly ash (LZFA) was prepared and used as a modified substrate for constructed wetland (CW) to enhance N and P removal. Single-factor and surface methodology (RSM) were used to optimize the preparation. The results showed that the maximum adsorption capacities of N and P were 17.26 mg/g and 21.48 mg/g. The decline in sorption capacity or diffusion coefficients of LZFA for N compared to zeolite synthesized from fly ash (ZFA) is mainly due to the decrease in surface negative charge and cation exchange capacity. The mechanism of P adsorption is attributed to the formation of La-O-P monodentate, bidentate mononuclear or bidentate binuclear inner-sphere complexation. Meanwhile, the introduction of Ca in waste lye is also involved in the P reaction. The N and P removal rates of LZFA modified subsurface flow constructed wetland (SFCW) were 2.67% and 7.33% higher than SFCW modified with gravel. In practical production, if a circular chain from coal ash production to use in green plant fertilizer can be established, the cost of treating P can be significantly reduced.
Unlocking the Future: Navigating 6G Research with Scientometrics and Emerging Trends
Authors: Al-Jamimi Hamdi A. , Makhashen Galal M. Bin , Al-Roubaiey Anas , Ahmad Naved , Ahmad Shakil 
Published: October 2023

Abstract
The advent of 6G, an emerging technology, has ushered in transformative changes across multiple industries. Its numerous benefits have paved the way for extensive research opportunities, thereby capturing the attention of the scholarly community. Given the swift proliferation of 6G-related research, there is a pressing need for a comprehensive examination of the existing knowledge landscape in this domain. While a few review articles have been published to address this demand, presenting the latest accomplishments and challenges of 6G technology from diverse perspectives, a Scientometrics evaluation of the current state of 6G still needs to be explored. In this investigation, we undertook a thorough Scientometrics analysis encompassing conference papers, journal articles, and review papers related to 6G indexed by the Web of Science (WoS) between 2015 and 2022. The outcomes of this analysis yielded valuable insights, including annual publication and citation trends, burgeoning research domains, the ten most influential papers, favored publication platforms, and primary funding sources. These findings contribute meaningful insights and offer a range of recommendations, serving as a valuable reference for both novice and experienced researchers venturing into the realm of 6G research in the times ahead.
Plasma C-peptide, Mammographic Density Parameters, Mammographic Texture Feature, and Risk of Breast Cancer
Authors: Azam Shadi , Peng Cheng , Rosner Bernard , Goncalves Marcus , Phillips Erica , Eliassen A. Heather , Heine John , Hankinson Susan , Tamimi Rulla 
Published: October 2023

Abstract

Background
High levels of insulin may increase the risk of breast cancer (BC). We studied the association between C-peptide levels as a marker of high-level endogenous insulin, mammographic density (MD) parameters, and BC risk. We also examined the association between C-peptide and BC risk varies by MD status.
Methods:
We conducted a nested case-control study (n=1260 cases; n=2221 controls) in the Nurses’ Health Study (NHS) and NHS2. We assessed MD parameters and V (a measure of grayscale variation). MD parameters were square root-transformed. Linear and logistic regression models were used to analyze the associations between C-peptide and MD parameters among controls, and C-peptide with breast cancer, respectively. Multivariable models were adjusted for matching factors and established risk factors for BC.
Results:
In multivariable models including BMI, C-peptide was significantly inversely associated with percent MD and positively associated with non-dense area. However, no associations were detected with dense area and V measure. C-peptide was associated with an increased risk of invasive BC (top vs. bottom quartile, odds ratio = 1.40, 95% confidence interval :1.08 to 1.81). The association was stronger for ER-negative disease (adjusted OR=1.82, 95% CI: 1.13 to 2.94), though heterogeneity by ER status was not significant. There was no significant heterogeneity by menopausal status. There was no evidence of multiplicative interaction between C-peptide, and MD parameters and risk of BC (All p-interactions>0.11).
Conclusion
Our results suggest a positive association between C-peptide and BC risk. Furthermore, MD parameters do not seem to modify the association between C-peptide and BC risk.
Randomized controlled trial of a social media campaign to promote COVID-19 vaccination in Nigeria
Authors: Evans William D. , Bingenheimer Jeffrey B. , Long Michael , Ndiaye Khadidiatou , Donati Dante , Rao Nandan M. , Akaba Selinam , Agha Sohail 
Published: October 2023

Abstract
Background
The COVID-19 pandemic has challenged public health and behavior change programs and has also led to innovative interventions and research. In low -and middle-income countries (LMICs) such as Nigeria, new strategies to promote vaccination, increase pro-vaccination social norms, and reduce vaccine hesitancy have been deployed through social media campaigns and evaluated using digital media platforms.
Methods
The aim of this study was to conduct two randomized controlled evaluations of social media content designed to promote COVID-19 vaccination and to complement research on a nationwide vaccination promotion campaign in Nigeria run in 2022. We conducted two studies in March and August 2022 among Nigerians drawn from 31 states that were not the target of the nationwide campaign. Participants were randomized to receive the pro-vaccination social media campaign or not and data were collected at pre- and post-test to evaluate psychosocial predictors of vaccination and vaccination outcomes following a theory of change based on Diffusion of Innovations, Social Norms Theory, and the Motivation, Opportunity, Ability (MOA) Framework. Data were collected through a novel intervention delivery and data collection platform through social media, and this study demonstrates the capability and potential of new social media-based data collection techniques.
Results
The study found that pro-vaccination social norms and vaccination rates increased, and vaccine hesitancy decreased, among participants randomized to the social media intervention study arm.
Conclusion
Social media campaigns are a promising approach to increasing vaccination at scale in LMICs, and social norms are an important factor in promoting vaccination, which is consistent with the Social Norms Theory. We describe implications for future vaccination campaigns and identify future research priorities in this area. The study was conducted in accordance with the Declaration of Helsinki, and approved by the Institutional Review Board of the George Washington University (protocol code NCR213718, approved [9 September 2021]) and by the National Health Research Ethics Committee (NHREC) in Nigeria (approved 6 September 2021). Trial registration: Pan African Clinical Trial Registry number PACTR202310811597445 on 20/10/2023.
Understanding vessel noise across a network of marine protected areas
Authors: McKenna Megan F , Rowell Timothy J , Margolina Tetyana , Baumann-Pickering Simone , Solsona-Berga Alba , Adams Jeffrey D , Joseph John , Kim Ella B , Kok Annebelle , Kügler Anke , Lammers Marc O , Merkens Karlina , Reeves Lindsey Peavey , Southall Brandon , Stimpert Alison K , Barkowski Jack , Thompson Michael A , VanParijs Sofie , Wall Carrie C , Zang Eden J , Hatch Leila T 
Published: October 2023

Abstract
Protected areas are typically managed as a network of sites exposed to varying anthropogenic conditions. Managing these networks benefits from monitoring of conditions across sites to help prioritize coordinated efforts. Monitoring marine vessel activity and related underwater noise impacts across a network of protected areas, like the U.S. National Marine Sanctuary system, helps managers ensure the quality of habitats used by a wide range of marine species. Here, we use underwater acoustic detection of vessels to quantify vessel noise at 25 locations within eight marine sanctuaries including the Hawaiian Archipelago and the U.S. east and west coasts. Vessel noise metrics were paired with Automatic Identification System (AIS) vessel tracking data to derive a suite of robust vessel noise indicators for use across the network of marine protected areas. Network-wide comparisons revealed a spectrum of vessel noise conditions that closely matched AIS vessel traffic composition. Shifts in vessel noise were correlated with the decrease in vessel activity in early COVID-19 pandemic and vessel speed reduction initiatives. Improving our understanding of vessel noise conditions in these protected areas can help direct opportunities for reducing vessel noise, such as establishing and maintaining noise-free periods, enhancing port efficiency, engaging with regional and international vessel quieting initiatives, and leveraging co-benefits of management actions for reducing ocean noise.
The Effects of Reviewers' Security and Privacy Perceptions on Fin Apps' Performance: A Textual Analysis
Authors: Alnsour Yazan , Juma'h Ahmad H. 
Published: October 2023

Abstract
Large volumes of app reviews generated by online users have strategic value for app providers. We investigate how Fin app users consider information security and privacy in their reviews and how these concerns affect the app’s performance in terms of its overall rating. We used 71,044 online reviews from multiple Fin apps in the digital market. We analyzed the unstructured data by conducting a textual analysis and developed a semi-supervised machine-learning model to extract insights regarding how users perceive security and privacy. The main results showed that perceived concerns about security and privacy negatively affect the apps' performance.
New insights into the mechanism and DNA-sequence specificity of INO80 chromatin remodeling
Authors: Bartholomew Blaine , Shukla Shagun , Ngubo Mzwanele , Paul Somnath , Persinger Jim , Brahma Sandipan 
Published: October 2023

Abstract

The INO80 complex stood out in a large family of ATP-dependent chromatin remodelers because of its ATPase domain binding and translocating on DNA at the edge of nucleosomes, rather than at two helical turns from the center of DNA that is wrapped around nucleosomes. This unique property of INO80 was thought to account for its singular role in nucleosome placement at gene promoters in a DNA-sequence dependent manner that is crucial for transcription regulation. Now, we uncover INO80 functions differently than previously thought with its ATPase domain translocating on DNA close to the center of nucleosomes, like other remodelers. Our discovery also reveals the physical properties of the first ~36 bp of DNA on the entry side of nucleosomes is the main determinant for the DNA specificity of INO80 rather than the properties of the extranucleosomal DNA. The DNA sequence sensitive step of INO80 is after DNA is displaced from the histone octamer on the entry side of nucleosomes and 20 bp of DNA are moved out the exit side. We find the ATPase domain and Arp5 subunit of INO80 are likely involved in INO80’s DNA specificity and the mechanism of INO80 remodeling is substantially different than originally proposed.
Fungal biodegradation unravels potential low-tech pathway for paper electronics waste valorization
Authors: Schneiter Arthur , Rüegg Kasimir , Kim Jaemin , Biselli Silvia , Vaideeswaran Kaushik , Sereda Olha , Briand Danick , Bindschedler Saskia 
Published: October 2023

Abstract
Metallic traces are core component of simple electronic products such as printed circuit boards (PCB) and radio frequency identification (RFID) tags, which are central items of the Internet of Things (IoT). However, these systems come with an ecological footprint since metals, even if present at very low amounts, are non-renewable resources. Currently, more than 80% of electronic waste is still not properly recycled and the recent global semiconductor crisis demonstrates a risk of metal shortage in the upcoming decades. Paper electronics represent a sustainable alternative to standard FR4 PCBs since paper can be recycled, albeit the end-of-life treatment of the silver or copper printed metallization remains a major issue. Here, we investigated a microbial pathway for their biorecycling, where paper would be used as a carbon source for microbial growth while the metallic traces would be recovered through microbe-metal interactions. More specifically, we hypothesized that a bacterium and a fungus in co-cultures could use technical paper as a sole carbon source. In addition, they would cooperate to first solubilize, then translocate, and finally biomineralize Ag or Cu contained in metallic traces printed over the technical paper. We also tested whether an alternative carbon and nutrient source, spent coffee grounds, may enhance microbial growth and activity to eventually design a process fitting an industrial scale. Two fungal strains (Boeremia exigua and Neurospora sitophila) and two bacterial strains (Pseudomonas putida and Cupriavidus necator) were compared, alone and combined, under various nutritive conditions.
Results:
The presence of bacteria associated to fungi did not have any direct effect on metal-related processes. However, bacteria altered the architecture of the mycelial network, eventually modulating metal transformations. Hence, fungal activity only effectively led to metal mobilization and then immobilization through both extra- and intracellular precipitates.
Conclusions:
Although at this stage metal recovery was not actually achieved due to slow biodegradation, the results give a clear signal to the biotechnology communities that valorizing organic and electronic waste together may be envisioned.
A novel experimental method for determination of forming limits with generalized non- planar stress state using hydro-assisted incremental forming
Authors: Fatemi Afshin , Dariani Bijan Mollaei 
Published: October 2023

Abstract

Analytical prediction of forming limits under generalized non-planar stress state in processes such as hydroforming and incremental forming was topic of several investigations; however, limited evaluating experimental methods were mentioned. In this paper, hydro-assisted incremental forming (HAIF) is introduced as a hybrid process of incremental forming and hydromechanical deep drawing with enhanced formability resulted of simultaneous exertion of normal and through thickness stresses. A test method is invented based on this process and experimental and finite element assessment of forming limits are executed. Previous analytical forming limit curves predicted by the present authors are evaluated using experimental tests and finite element simulations and good compatibility is observed. It is again confirmed that application of normal and through thickness stresses enhance formability in all strain paths specially in plane strain mode.