bluuebunny/crossref_metadata_2025_split huggingface dataset:
Hypoxia-induced signaling in the cardiovascular system: pathogenesis and therapeutic targets
Authors: Zhao Yongchao , Xiong Weidong , Li Chaofu , Zhao Ranzun , Lu Hao , Song Shuai , Zhou You , Hu Yiqing , Shi Bei , Ge Junbo 
Published: November 2023

AbstractHypoxia, characterized by reduced oxygen concentration, is a significant stressor that affects the survival of aerobic species and plays a prominent role in cardiovascular diseases. From the research history and milestone events related to hypoxia in cardiovascular development and diseases, The "hypoxia-inducible factors (HIFs) switch" can be observed from both temporal and spatial perspectives, encompassing the occurrence and progression of hypoxia (gradual decline in oxygen concentration), the acute and chronic manifestations of hypoxia, and the geographical characteristics of hypoxia (natural selection at high altitudes). Furthermore, hypoxia signaling pathways are associated with natural rhythms, such as diurnal and hibernation processes. In addition to innate factors and natural selection, it has been found that epigenetics, as a postnatal factor, profoundly influences the hypoxic response and progression within the cardiovascular system. Within this intricate process, interactions between different tissues and organs within the cardiovascular system and other systems in the context of hypoxia signaling pathways have been established. Thus, it is the time to summarize and to construct a multi-level regulatory framework of hypoxia signaling and mechanisms in cardiovascular diseases for developing more therapeutic targets and make reasonable advancements in clinical research, including FDA-approved drugs and ongoing clinical trials, to guide future clinical practice in the field of hypoxia signaling in cardiovascular diseases.
Apoptotic dysregulation mediates stem cell competition and tissue regeneration
Authors: Yusupova Marianna , Ankawa Roi , Yosefzon Yahav , Meiri David , Bachelet Ido , Fuchs Yaron 
Published: November 2023

AbstractSince adult stem cells are responsible for replenishing tissues throughout life, it is vital to understand how failure to undergo apoptosis can dictate stem cell behavior both intrinsically and non-autonomously. Here, we report that depletion of pro-apoptotic Bax protein bestows hair follicle stem cells with the capacity to eliminate viable neighboring cells by sequestration of TNFα in their membrane. This in turn induces apoptosis in “loser” cells in a contact-dependent manner. Examining the underlying mechanism, we find that Bax loss-of-function competitive phenotype is mediated by the intrinsic activation of NFκB. Notably, winner stem cells differentially respond to TNFα, owing to their elevated expression of TNFR2. Finally, we report that in vivo depletion of Bax results in an increased stem cell pool, accelerating wound-repair and de novo hair follicle regeneration. Collectively, we establish a mechanism of mammalian cell competition, which can have broad therapeutic implications for tissue regeneration and tumorigenesis.
Catalyst switch strategy enabled a single polymer with five different crystalline phases
Authors: Zhang Pengfei , Ladelta Viko , Abou-hamad Edy , Müller Alejandro J. , Hadjichristidis Nikos 
Published: November 2023

AbstractWell-defined multicrystalline multiblock polymers are essential model polymers for advancing crystallization physics, phase separation, self-assembly, and improving the mechanical properties of materials. However, due to different chain properties and incompatible synthetic methodologies, multicrystalline multiblock polymers with more than two crystallites are rarely reported. Herein, by combining polyhomologation, ring-opening polymerization, and catalyst switch strategy, we synthesized a pentacrystalline pentablock quintopolymer, polyethylene-b-poly(ethylene oxide)-b-poly(ε-caprolactone)-b-poly(L-lactide)-b-polyglycolide (PE-b-PEO-b-PCL-b-PLLA-b-PGA). The fluoroalcohol-assisted catalyst switch enables the successful incorporation of a high melting point polyglycolide block into the complex multiblock structure. Solid-state nuclear magnetic resonance spectroscopy, X-ray diffraction, and differential scanning calorimetry revealed the existence of five different crystalline phases.
LHP1-mediated epigenetic buffering of subgenome diversity and defense responses confers genome plasticity and adaptability in allopolyploid wheat
Authors: Li Zijuan , Zhang Yuyun , Ding Ci-Hang , Chen Yan , Wang Haoyu , Zhang Jinyu , Ying Songbei , Wang Meiyue , Zhang Rongzhi , Liu Jinyi , Xie Yilin , Tang Tengfei , Diao Huishan , Ye Luhuan , Zhuang Yili , Teng Wan , Zhang Bo , Huang Lin , Tong Yiping , Zhang Wenli , Li Genying , Benhamed Moussa , Dong Zhicheng , Gou Jin-Ying , Zhang Yijing 
Published: November 2023

AbstractPolyploidization is a major driver of genome diversification and environmental adaptation. However, the merger of different genomes may result in genomic conflicts, raising a major question regarding how genetic diversity is interpreted and regulated to enable environmental plasticity. By analyzing the genome-wide binding of 191 trans-factors in allopolyploid wheat, we identified like heterochromatin protein 1 (LHP1) as a master regulator of subgenome-diversified genes. Transcriptomic and epigenomic analyses of LHP1 mutants reveal its role in buffering the expression of subgenome-diversified defense genes by controlling H3K27me3 homeostasis. Stripe rust infection releases latent subgenomic variations by eliminating H3K27me3-related repression. The simultaneous inactivation of LHP1 homoeologs by CRISPR–Cas9 confers robust stripe rust resistance in wheat seedlings. The conditional repression of subgenome-diversified defenses ensures developmental plasticity to external changes, while also promoting neutral-to-non-neutral selection transitions and adaptive evolution. These findings establish an LHP1-mediated buffering system at the intersection of genotypes, environments, and phenotypes in polyploid wheat. Manipulating the epigenetic buffering capacity offers a tool to harness cryptic subgenomic variations for crop improvement.
Wireless, battery-free, multifunctional integrated bioelectronics for respiratory pathogens monitoring and severity evaluation
Authors: Li Hu , Gong Huarui , Wong Tsz Hung , Zhou Jingkun , Wang Yuqiong , Lin Long , Dou Ying , Jia Huiling , Huang Xingcan , Gao Zhan , Shi Rui , Huang Ya , Chen Zhenlin , PARK Wooyoung , Li Ji Yu , Chu Hongwei , Jia Shengxin , Wu Han , Wu Mengge , Liu Yiming , Li Dengfeng , Li Jian , Xu Guoqiang , Chang Tianrui , Zhang Binbin , Gao Yuyu , Su Jingyou , Bai Hao , Hu Jie , Yiu Chun Ki , Xu Chenjie , Hu Wenchuang , Huang Jiandong , Chang Lingqian , Yu Xinge 
Published: November 2023

AbstractThe rapid diagnosis of respiratory virus infection through breath and blow remains challenging. Here we develop a wireless, battery-free, multifunctional pathogenic infection diagnosis system (PIDS) for diagnosing SARS-CoV-2 infection and symptom severity by blow and breath within 110 s and 350 s, respectively. The accuracies reach to 100% and 92% for evaluating the infection and symptom severity of 42 participants, respectively. PIDS realizes simultaneous gaseous sample collection, biomarker identification, abnormal physical signs recording and machine learning analysis. We transform PIDS into other miniaturized wearable or portable electronic platforms that may widen the diagnostic modes at home, outdoors and public places. Collectively, we demonstrate a general-purpose technology for rapidly diagnosing respiratory pathogenic infection by breath and blow, alleviating the technical bottleneck of saliva and nasopharyngeal secretions. PIDS may serve as a complementary diagnostic tool for other point-of-care techniques and guide the symptomatic treatment of viral infections.
Comprehensive mapping of lunar surface chemistry by adding Chang'e-5 samples with deep learning
Authors: Yang Chen , Zhang Xinmei , Bruzzone Lorenzo , Liu Bin , Liu Dawei , Ren Xin , Benediktsson Jon Atli , Liang Yanchun , Yang Bo , Yin Minghao , Zhao Haishi , Guan Renchu , Li Chunlai , Ouyang Ziyuan 
Published: November 2023

AbstractLunar surface chemistry is essential for revealing petrological characteristics to understand the evolution of the Moon. Existing chemistry mapping from Apollo and Luna returned samples could only calibrate chemical features before 3.0 Gyr, missing the critical late period of the Moon. Here we present major oxides chemistry maps by adding distinctive 2.0 Gyr Chang’e-5 lunar soil samples in combination with a deep learning-based inversion model. The inferred chemical contents are more precise than the Lunar Prospector Gamma-Ray Spectrometer (GRS) maps and are closest to returned samples abundances compared to existing literature. The verification of in situ measurement data acquired by Chang'e 3 and Chang'e 4 lunar rover demonstrated that Chang’e-5 samples are indispensable ground truth in mapping lunar surface chemistry. From these maps, young mare basalt units are determined which can be potential sites in future sample return mission to constrain the late lunar magmatic and thermal history.
Eicosanoid and eicosanoid-related inflammatory mediators and exercise intolerance in heart failure with preserved ejection fraction
Authors: Lau Emily S. , Roshandelpoor Athar , Zarbafian Shahrooz , Wang Dongyu , Guseh James S. , Allen Norrina , Varadarajan Vinithra , Nayor Matthew , Shah Ravi V. , Lima Joao A. C. , Shah Sanjiv J. , Yu Bing , Alotaibi Mona , Cheng Susan , Jain Mohit , Lewis Gregory D. , Ho Jennifer E. 
Published: November 2023

AbstractSystemic inflammation has been implicated in the pathobiology of heart failure with preserved ejection fraction (HFpEF). Here, we examine the association of upstream mediators of inflammation as ascertained by fatty-acid derived eicosanoid and eicosanoid-related metabolites with HFpEF status and exercise manifestations of HFpEF. Among 510 participants with chronic dyspnea and preserved LVEF who underwent invasive cardiopulmonary exercise testing, we find that 70 of 890 eicosanoid and related metabolites are associated with HFpEF status, including 17 named and 53 putative eicosanoids (FDR q-value < 0.1). Prostaglandin (15R-PGF2α, 11ß-dhk-PGF2α) and linoleic acid derivatives (12,13 EpOME) are associated with greater odds of HFpEF, while epoxides (8(9)-EpETE), docosanoids (13,14-DiHDPA), and oxylipins (12-OPDA) are associated with lower odds of HFpEF. Among 70 metabolites, 18 are associated with future development of heart failure in the community. Pro- and anti-inflammatory eicosanoid and related metabolites may contribute to the pathogenesis of HFpEF and serve as potential targets for intervention.
Integrated microwave photonic notch filter using a heterogeneously integrated Brillouin and active-silicon photonic circuit
Authors: Garrett Matthew , Liu Yang , Merklein Moritz , Bui Cong Tinh , Lai Choon Kong , Choi Duk-Yong , Madden Stephen J. , Casas-Bedoya Alvaro , Eggleton Benjamin J. 
Published: November 2023

AbstractMicrowave photonics (MWP) has unlocked a new paradigm for Radio Frequency (RF) signal processing by harnessing the inherent broadband and tunable nature of photonic components. Despite numerous efforts made to implement integrated MWP filters, a key RF processing functionality, it remains a long-standing challenge to achieve a fully integrated photonic circuit that can merge the megahertz-level spectral resolution required for RF applications with key electro-optic components. Here, we overcome this challenge by introducing a compact 5 mm × 5 mm chip-scale MWP filter with active E-O components, demonstrating 37 MHz spectral resolution. We achieved this device by heterogeneously integrating chalcogenide waveguides, which provide Brillouin gain, in a complementary metal-oxide-semiconductor (CMOS) foundry-manufactured silicon photonic chip containing integrated modulators and photodetectors. This work paves the way towards a new generation of compact, high-resolution RF photonic filters with wideband frequency tunability demanded by future applications, such as air and spaceborne RF communication payloads.
Vaginal microbial dynamics and pathogen colonization in a humanized microbiota mouse model
Authors: Mejia Marlyd E. , Mercado-Evans Vicki , Zulk Jacob J. , Ottinger Samantha , Ruiz Korinna , Ballard Mallory B. , Fowler Stephanie W. , Britton Robert A. , Patras Kathryn A. 
Published: November 2023

AbstractVaginal microbial composition is associated with differential risk of urogenital infection. Although Lactobacillus spp. are thought to confer protection against infection, the lack of in vivo models resembling the human vaginal microbiota remains a prominent barrier to mechanistic discovery. Using 16S rRNA amplicon sequencing of C57BL/6J female mice, we found that vaginal microbial composition varies within and between colonies across three vivaria. Noting vaginal microbial plasticity in conventional mice, we assessed the vaginal microbiome of humanized microbiota mice (HMbmice). Like the community structure in conventional mice, HMbmice vaginal microbiota clustered into community state types but, uniquely, HMbmice communities were frequently dominated by Lactobacillus or Enterobacteriaceae. Compared to conventional mice, HMbmice were less susceptible to uterine ascension by urogenital pathobionts group B Streptococcus (GBS) and Prevotella bivia. Although Escherichia and Lactobacillus both correlated with the absence of uterine GBS, vaginal pre-inoculation with exogenous HMbmouse-derived E. coli, but not Ligilactobacillus murinus, reduced vaginal GBS burden. Overall, HMbmice serve as a useful model to elucidate the role of endogenous microbes in conferring protection against urogenital pathogens.
Disrupting links between poverty, chronic stress, and educational inequality
Authors: Harms Madeline B. , Garrett-Ruffin Sherona D. 
Published: November 2023

AbstractThe income-achievement gap is a significant and stubborn problem in the United States, which has been exacerbated by the Covid-19 pandemic. In this article, we link two emerging literatures that have historically been disparate: the neurobiology of poverty as a form of early life stress, and research on educational policies with the potential to reduce SES-based disparities in academic achievement. In doing so, we (1) integrate the literature on poverty-related mechanisms that contribute to early life stress, alter neurobiology, and lead to educational inequities, and (2) based on this research, highlight policies and practices at the school/classroom level and broader structural level that have the potential to address the problem of inequity in our educational systems. We emphasize that educational inequity is a systemic issue, and its resolution will require coordination of local, state, and national policies.
Outlook of pandemic preparedness in a post-COVID-19 world
Authors: Williams B. Adam , Jones Charles H. , Welch Verna , True Jane M. 
Published: November 2023

AbstractThe COVID-19 pandemic was met with rapid, unprecedented global collaboration and action. Even still, the public health, societal, and economic impact may be felt for years to come. The risk of another pandemic occurring in the next few decades is ever-present and potentially increasing due to trends such as urbanization and climate change. While it is difficult to predict the next pandemic pathogen threat, making reasonable assumptions today and evaluating prior efforts to plan for and respond to disease outbreaks and pandemics may enable a more proactive, effective response in the future. Lessons from the COVID-19 response and pandemic influenza preparedness underscore the importance of strengthening surveillance systems, investing in early-stage research on pandemic pathogens and development of platform technologies, and diversifying response plans across a range of tactics to enable earlier access to safe and effective interventions in the next pandemic. Further, sustaining the robust vaccine manufacturing capacity built because of COVID-19 will keep it ready for rapid response in the future. These actions will not be successful without improved global coordination and collaboration. Everyone, including the biopharmaceutical industry, has a role to play in pandemic preparedness, and working together will ensure that the most lives are saved in the next pandemic.
Genomic data resources of the Brain Somatic Mosaicism Network for neuropsychiatric diseases
Authors: Garrison McKinzie A. , Jang Yeongjun , Bae Taejeong , Cherskov Adriana , Emery Sarah B. , Fasching Liana , Jones Attila , Moldovan John B. , Molitor Cindy , Pochareddy Sirisha , Peters Mette A. , Shin Joo Heon , Wang Yifan , Yang Xiaoxu , Akbarian Schahram , Chess Andrew , Gage Fred H. , Gleeson Joseph G. , Kidd Jeffrey M. , McConnell Michael , Mills Ryan E. , Moran John V. , Park Peter J. , Sestan Nenad , Urban Alexander E. , Vaccarino Flora M. , Walsh Christopher A. , Weinberger Daniel R. , Wheelan Sarah J. , Abyzov Alexej ,   BSMN Consortium, Amero Aitor Serres , Antaki Danny , Averbuj Dan , Ball Laurel , Bizzotto Sara , Bohrson Craig , Borges-Monroy Rebeca , Breuss Martin , Cho Sean , Chu Chong , Chung Changuk , Cortes-Ciriano Isidro , Coulter Michael , Daily Kenneth , Dias Caroline , D’Gama Alissa , Dou Yanmei , Erwin Jennifer , Flasch Diane A. , Frisbie Trenton J. , Galor Alon , Ganz Javier , Gulhan Doga , Hill Robert , Huang August Yue , Jaffe Andrew , Jourdon Alexandre , Juan David , Khoshkhoo Sattar , Kim Sonia , Kopera Huira C. , Kwan Kenneth Y. , Kwon Minseok , Langmead Ben , Lee Eunjung Alice , Linker Sara , Lobon Irene , Lodato Michael A. , Luquette Lovelace J. , Mathern Gary , Marques-Bonet Tomas , Maury Eduardo A. , Miller Michael , Moruno Manuel Solis , Narurkar Rujuta , Paquola Apua , Pattni Reenal , Perez Raquel Garcia , Povolotskaya Inna , Reed Patrick , Rodin Rachel , Rosenbluh Chaggai , Scuderi Soraya , Sherman Maxwell , Straub Richard , Soriano Eduardo , Sun Chen , Thorpe Jeremy , Viswanadham Vinay , Wang Meiyan , Zhao Xuefang , Zhou Bo , Zhou Weichen , Zhou Zinan , Zhu Xiaowei 
Published: November 2023

AbstractSomatic mosaicism is defined as an occurrence of two or more populations of cells having genomic sequences differing at given loci in an individual who is derived from a single zygote. It is a characteristic of multicellular organisms that plays a crucial role in normal development and disease. To study the nature and extent of somatic mosaicism in autism spectrum disorder, bipolar disorder, focal cortical dysplasia, schizophrenia, and Tourette syndrome, a multi-institutional consortium called the Brain Somatic Mosaicism Network (BSMN) was formed through the National Institute of Mental Health (NIMH). In addition to genomic data of affected and neurotypical brains, the BSMN also developed and validated a best practices somatic single nucleotide variant calling workflow through the analysis of reference brain tissue. These resources, which include >400 terabytes of data from 1087 subjects, are now available to the research community via the NIMH Data Archive (NDA) and are described here.
Benchmarking of a microgel-reinforced hydrogel-based aqueous lubricant against commercial saliva substitutes
Authors: Pabois Olivia , Avila-Sierra Alejandro , Ramaioli Marco , Mu Mingduo , Message Yasmin , You Kwan-Mo , Liamas Evangelos , Kew Ben , Durga Kalpana , Doherty Lisa , Sarkar Anwesha 
Published: November 2023

AbstractXerostomia, the subjective sensation of ‘dry mouth’ affecting at least 1 in 10 adults, predominantly elders, increases life-threatening infections, adversely impacting nutritional status and quality of life. A patented, microgel-reinforced hydrogel-based aqueous lubricant, prepared using either dairy or plant-based proteins, has been demonstrated to offer substantially enhanced lubricity comparable to real human saliva in in vitro experiments. Herein, we present the benchmarking of in vitro lubrication performance of this aqueous lubricant, both in its dairy and vegan formulation against a range of widely available and employed commercial saliva substitutes, latter classified based on their shear rheology into “liquids”, “viscous liquids” and “gels”, and also had varying extensional properties. Strikingly, the fabricated dairy-based aqueous lubricant offers up to 41–99% more effective boundary lubrication against liquids and viscous liquids, irrespective of topography of the tested dry mouth-mimicking tribological surfaces. Such high lubricity of the fabricated lubricants might be attributed to their limited real-time desorption (7%) from a dry-mouth mimicking hydrophobic surface unlike the tested commercial products including gels (23–58% desorption). This comprehensive benchmarking study therefore paves the way for employing these microgel-based aqueous lubricant formulations as a novel topical platform for dry mouth therapy.
Using deep neural networks as a guide for modeling human planning
Authors: Kuperwajs Ionatan , Schütt Heiko H. , Ma Wei Ji 
Published: November 2023

AbstractWhen developing models in cognitive science, researchers typically start with their own intuitions about human behavior in a given task and then build in mechanisms that explain additional aspects of the data. This refinement step is often hindered by how difficult it is to distinguish the unpredictable randomness of people’s decisions from meaningful deviations between those decisions and the model. One solution for this problem is to compare the model against deep neural networks trained on behavioral data, which can detect almost any pattern given sufficient data. Here, we apply this method to the domain of planning with a heuristic search model for human play in 4-in-a-row, a combinatorial game where participants think multiple steps into the future. Using a data set consisting of 10,874,547 games, we train deep neural networks to predict human moves and find that they accurately do so while capturing meaningful patterns in the data. Thus, deviations between the model and the best network allow us to identify opportunities for model improvement despite starting with a model that has undergone substantial testing in previous work. Based on this analysis, we add three extensions to the model that range from a simple opening bias to specific adjustments regarding endgame planning. Overall, our work demonstrates the advantages of model comparison with a high-performance deep neural network as well as the feasibility of scaling cognitive models to massive data sets for systematically investigating the processes underlying human sequential decision-making.
Identifying who adolescents prefer as source of information within their social network
Authors: Slagter Scarlett K. , Gradassi Andrea , van Duijvenvoorde Anna C.K. , van den Bos Wouter 
Published: November 2023

AbstractAdolescents are highly influenced by their peers within their social networks. This social influence can stem from both unsolicited peer pressure and the active search for guidance. While extensive research examined the mechanisms of peer pressure, little is known about who adolescents prefer as a source of information. To address this gap, we conducted two independent studies using a novel social search paradigm that allows participants to choose which social sources they wish to observe. In both studies, adolescents demonstrated a preference for their friends over non-friends, as well as for peers who were perceived as trustworthy. Across both studies, we found mixed evidence for the role of perceived popularity as a selection criterion. Notable, study 2 revealed the significance of “cool”, “admirable” and “acting mean” as additional characteristics of preferred peers, traits that are often associated with elevated peer status. It also revealed an interest for peers perceived as being smart. These findings highlight the active role adolescents have in choosing social sources and emphasize the importance of multiple peer characteristics. Future research should investigate whether adolescents’ interest in these types of peers is contingent upon specific social contexts, age groups, and peer cultures.