bluuebunny/crossref_metadata_2025_split huggingface dataset:
The use of linseed oil cake in the diets of rohu, Labeo rohita (Hamilton), after solid-state fermentation with a fish gut bacterium, Bacillus pumilus (KF640221): an appraisal on growth, digestibility, body composition, and hematobiochemical profile
Authors: Banerjee Sudeshna , Kari Zulhisyam Abdul , Téllez-Isaías Guillermo , Ghosh Koushik 
Published: October 2023

IntroductionLinseed or flaxseed (Linum usitassimum L.) contains a prospective source of protein and energy to be utilized in animal feed. This study aimed at re-cycling and value-addition of Linseed Oil Cake (LOC) for formulation of non-conventional carp diets. MethodsThe LOC was bio-processed through solid state fermentation (SSF) with a fish gut bacterium, Bacillus pumilus (KF640221). Nine experimental sets of diets were formulated using raw (R1-R4) and SSF-processed (F1-F4) LOC at 10%, 20%, 30% and 40% levels substituting fishmeal as well as other ingredients in a reference diet, and rohu, Labeo rohita fingerlings (2.08±0.03 g) were fed for 70 days feeding trial. Growth, carcass composition, activities of digestive enzymes, digestibility and haemato-biochemical parameters were studied following standard methodologies.ResultsSSF significantly (P&lt; 0.05) improved crude protein along with amino acids, whereas crude fibre and antinutritional factors were reduced considerably. Experimental diets were isocaloric (4.8 kcal) and isonitrogenous (36%). Diets with bio-processed LOC had significantly better performance than the raw LOC. Fish fed diet F3 with 30% fermented LOC resulted in the highest weight gain (6.25 ± 0.09 g), specific growth rate (% day -1) and carcass protein deposition (16.77±0.34%). Activities of the digestive enzymes (amylase, lipase and protease) were also significantly (P&lt;0.05) higher in fish receiving diets containing fermented LOC. Analyses of blood parameters revealed that haemoglobin, erythrocytes, leukocytes, plasma lipid, total plasma protein, albumin and globulin contents were increased, while plasma glutamic-oxaloacetic transaminase (GOT) and glutamic-pyruvic transaminase (GPT) levels were decreased in fish fed bio-processed LOC supplemented diets.ConclusionThe present study might propose substitution of fish meal along with other conventional ingredients by incorporation of 30% SSF-processed LOC in the diets of rohu with no negative effect to the growth performance, carcass composition and feed utilization.
A systematic review of health disparities research in deep brain stimulation surgery for Parkinson’s disease
Authors: Memon Adeel A. , Gelman Kate , Melott Joseph , Billings Rebecca , Fullard Michelle , Catiul Corina , Miocinovic Svjetlana , Amara Amy W. 
Published: October 2023

BackgroundDeep brain stimulation (DBS) is the primary surgical intervention for Parkinson’s disease (PD) patients with insufficient response to medication, significantly improving motor symptoms and quality of life. Despite FDA approval for over two decades, access to this therapy remains limited. This systematic review aims to evaluate the influence of gender, race/ethnicity, socioeconomic status, and age on health disparities associated with DBS for PD, providing an overview of current research in this field.MethodsA systematic literature search was conducted in PubMed/MEDLINE, Embase, Web of Science and Cochrane databases from 1960 to September 12th, 2023, following Preferred Reporting Items for Systematic Reviews and Meta-Analysis guidelines. Studies that examine the disparities in accessing DBS among patients with PD were included, comparing different demographic factors. Findings were synthesized and presented narratively to identify and understand DBS disparities.ResultsAfter screening for relevance, 25 studies published between 1960 and 2023 were included, with 16 studies meeting full-text review criteria. While reviewing the references of the 16 articles, two additional studies were included, bringing the total number of included studies to 18. Most studies originated from the United States (44%). The identified studies were categorized as identifying disparities, understanding disparities, or reducing disparities. The majority focused on identifying disparities (72%), while fewer studies delved into understanding the underlying factors (28%). No studies evaluated strategies for reducing disparities. The findings indicate that elderly, female, and Black people, as well as those from low socioeconomic backgrounds and developing countries face greater obstacles in accessing DBS for PD.ConclusionThis study highlights factors contributing to disparities in DBS utilization for PD, including race, gender, and socioeconomic status. Public health policymakers, practitioners, and clinicians should recognize these inequalities and work toward reducing disparities, particularly among vulnerable populations.
The impact of early adversity on the cerebral cortex - a Mendelian randomization study
Authors: Wang Zhen , Zou Jing , Zhang Le , Ning Jinghua , Zhang Xin , Jiang Bei , Liang Yi , Zhang Yuzhe 
Published: October 2023

BackgroundThe early adversity is associated with a series of negative outcomes in adulthood, and the impact on the cerebral cortex may be one of the fundamental causes of these adverse consequences in adulthood. In this study, we aim to investigate the causal relationship between early adversity and changes in cerebral cortex structure using Mendelian randomization (MR) analysis.MethodsThe GWAS summary statistics of 6 early adversity traits were obtained from individuals of European ancestry in the UK Biobank. The GWAS summary statistics of 34 known functional cortical regions were obtained from the ENIGMA Consortium. Causal relationships between the adversity factors and brain cortical structure were assessed using the inverse-variance weighted (IVW), MR-Egger, and weighted median methods, with IVW being the primary evaluation method. Cochran’s Q-test, MR-PRESSO, leave-one-out analysis, and funnel plot examination were employed to detect potential heterogeneity and pleiotropy, as well as to identify and exclude outliers.ResultsAt a global level, no causal relationship was found between early adversity and cortical thickness (TH) or surface area (SA) of the brain. However, at the regional level, early adversity was found to potentially influence the TH of the caudal anterior cingulate, superior temporal, entorhinal, paracentral, lateral occipital, banks of the superior temporal sulcus, and supramarginal regions, as well as the SA of the pars triangularis, lateral occipital, parahippocampal, medial orbitofrontal, and isthmus cingulate regions. All findings were nominally significant and passed sensitivity analyses, with no significant heterogeneity or pleiotropy detected.DiscussionOur study provides evidence for the association between early adversity and alterations in brain cortical structure, which may serve as a foundation for certain mental disorders. Furthermore, magnetic resonance imaging (MRI) might be considered as a promising tool to aid healthcare professionals in identifying individuals with a history of adverse experiences, allowing for early interventions.
Comparison of robotic-assisted versus conventional laparoscopic surgery in colorectal cancer resection: a systemic review and meta-analysis of randomized controlled trials
Authors: Huang Zhilong , Huang Shibo , Huang Yanping , Luo Raoshan , Liang Weiming 
Published: October 2023

IntroductionThere is still controversy on whether or not robot-assisted colorectal surgery (RACS) have advantages over laparoscopic-assisted colorectal surgery(LACS).Materials and methodsThe four databases (PubMed, Embase, Web of Science and Cochrane Library)were comprehensively searched for randomized controlled trials (RCTs) comparing the outcomes of RACS and LACS in the treatment of colorectal cancer from inception to 22 July 2023.ResultsEleven RCTs were considered eligible for the meta-analysis. Compared with LACS,RACS has significantly longer operation time(MD=5.19,95%CI: 18.00,39.82, P&lt;0.00001), but shorter hospital stay(MD=2.97,95%CI:−1.60,−0.33,P = 0.003),lower conversion rate(RR=3.62,95%CI:0.40,0.76,P = 0.0003), lower complication rate(RR=3.31,95%CI:0.64,0.89,P=0.0009),fewer blood loss(MD=2.71,95%CI:−33.24,−5.35,P = 0.007),lower reoperation rate(RR=2.12, 95%CI:0.33,0.96,P=0.03)and longer distal resection margin(MD=2.16, 95%CI:0.04,0.94, P = 0.03). There was no significantly difference in harvested lymph nodes, the time of first flatus, the time of first defecation,the time of first resume diet, proximal resection margin, readmission rates, mortalities and CRM+ rates between two group.ConclusionsOur study indicated that RACS is a feasible and safe technique that can achieve better surgical efficacy compared with LACS in terms of short-term outcomes.Systematic review registrationhttps://www.crd.york.ac.uk/prospero/, identifier CRD42023447088.
Optic disc edema during strict 6° head-down tilt bed rest is related to one-carbon metabolism pathway genetics and optic cup volume
Authors: Zwart Sara R. , Macias Brandon R. , Laurie Steven S. , Ferguson Connor , Stern Claudia , Suh Alex , Melin M. Mark , Young Millennia , Bershad Eric , Smith Scott M. 
Published: October 2023

Some astronauts on International Space Station missions experience neuroophthalmological pathologies as part of spaceflight associated neuro-ocular syndrome (SANS). Strict head-down tilt bed rest (HDTBR) is a spaceflight analog that replicates SANS findings and those who had 3–4 risk alleles (G and C alleles from the methionine synthase reductase [MTRR] A66G and serine hydroxymethyltransferase [SHMT1] C1420T, respectively) as compared to 1-2 risk alleles, had a greater increase in total retinal thickness (TRT). The objective of this study was to identify factors that contribute to the individual variability of the development of SANS in a 60 d HDTBR at the German Aerospace Center’s:envihab facility, Cologne Germany. 22 of 24 subjects who participated in the HDTBR study provided blood samples for genetic analysis. Total retinal thickness and optic cup volume were measured before and after bed rest. Subjects with 3–4 versus 0-2 risk alleles had greater ΔTRT during and after bed rest, and the model improved with the addition of baseline optic cup volume. This bed rest study confirms that variants of MTRR and SHMT1 are associated with ocular pathologies. Subjects with more risk alleles had the greatest HDTBR-induced ΔTRT, reaffirming that genetics predispose some individuals to developing SANS. Preflight optic cup volume and genetics better predict ΔTRT than either one alone. Whether nutritional supplements can override the genetic influences on biochemistry, physiology, and pathophysiology remains to be tested. These findings have significant implications for both aerospace and terrestrial medicine.
Syntactic complexity differentially affects auditory sentence comprehension performance for individuals with age-related hearing loss
Authors: Shin Junyoung , Noh Shinhee , Park Jimin , Sung Jee Eun 
Published: October 2023

ObjectivesThis study examined whether older adults with hearing loss (HL) experience greater difficulties in auditory sentence comprehension compared to those with typical-hearing (TH) when the linguistic burdens of syntactic complexity were systematically manipulated by varying either the sentence type (active vs. passive) or sentence length (3- vs. 4-phrases).MethodsA total of 22 individuals with HL and 24 controls participated in the study, completing sentence comprehension test (SCT), standardized memory assessments, and pure-tone audiometry tests. Generalized linear mixed effects models were employed to compare the effects of sentence type and length on SCT accuracy, while Pearson correlation coefficients were conducted to explore the relationships between SCT accuracy and other factors. Additionally, stepwise regression analyses were employed to identify memory-related predictors of sentence comprehension ability.ResultsOlder adults with HL exhibited poorer performance on passive sentences than on active sentences compared to controls, while the sentence length was controlled. Greater difficulties on passive sentences were linked to working memory capacity, emerging as the most significant predictor for the comprehension of passive sentences among participants with HL.ConclusionOur findings contribute to the understanding of the linguistic-cognitive deficits linked to age-related hearing loss by demonstrating its detrimental impact on the processing of passive sentences. Cognitively healthy adults with hearing difficulties may face challenges in comprehending syntactically more complex sentences that require higher computational demands, particularly in working memory allocation.
Pregnancy in autistic women and social medical considerations: scoping review and meta- synthesis
Authors: Ferrara Rosaria , Ricci Pasquale , Damato Felice Marco , Iovino Leonardo , Ricci Lidia , Cicinelli Giovanni , Simeoli Roberta , Keller Roberto 
Published: October 2023

IntroductionThis article addresses a topic that has been largely overlooked by scientific literature, namely pregnancy in autistic women. Generally, the issue of sexuality in disability, particularly in disabled women, autistic or otherwise, has been underexplored. However, it is necessary to scientifically investigate this topic to propose adequate social and health policies. Therefore, we chose to conduct a scoping review to answer three main questions: “What does it mean for an autistic woman to be pregnant?”; “How do these two conditions coexist?”; “Are health services prepared to receive this population adequately or does autism become a stigma for pregnant women?”MethodsWe conducted a systematic review and qualitative thematic synthesis following the Preferred Reporting Guidelines for Systematic Reviews and Meta-Analyses on autistic women and pregnancy in the last 10 years.ResultsThe studies included in our review are 7, extremely diverse in terms of methodologies and sample sizes. Despite the heterogeneity of samples and methodologies, all research tends to highlight the following results. For autistic women during pregnancy, three areas seem to be the most difficult: sensory issues, mood disorders, and relationships with specialists.DiscussionOur study found that women with ASD face unique challenges during childbirth that differ from those of neurotypical women. Participants often felt belittled, ignored, and uninformed about the care they received, and being placed at the centre of attention was often seen as negative and hindering rather than positive. However, the research shows us how some “expected” results, such as difficulties in breastfeeding, have been disproven.
Visual–vestibular sensory integration during congruent and incongruent self-rotation percepts using caloric vestibular stimulation
Authors: Kirollos Ramy , Herdman Chris M. 
Published: October 2023

Introduction: The present study sets out to determine which sensory system mostly influences self-motion perception when visual and vestibular cues are in conflict. We paired caloric vestibular stimulation that signaled motion in either the clockwise or counter-clockwise direction with a visual display that indicated self-rotation in either the same or opposite directions.Methods: In Experiment 1 (E1), caloric vestibular stimulation was used to produce vestibular circular vection. In Experiment 2 (E2), a virtual optokinetic drum was used to produce visual circular vection in a VR headset. Vection speed, direction, and duration were recorded using a potentiometer knob the participant controlled in E1 and E2. In Experiment 3 (E3), visual and vestibular stimuli were matched to be at approximately equal speeds across visual and vestibular modalities for each participant setting up Experiment 4 (E4). In E4, participants observed a moving visual pattern in a virtual reality (VR) headset while receiving caloric vestibular stimulation. Participants rotated the potentiometer knob while attending to visual–vestibular stimuli presentations to indicate their perceived circular vection. E4 had two conditions: 1) A congruent condition where calorics and visual display indicated circular vection in the same direction; 2) an incongruent condition where calorics and visual display indicated circular vection in opposite directions.Results and discussion: There were equal reports of knob rotation in the direction consistent with the visual and vestibular self-rotation direction in the incongruent condition of E4 across trials. There were no significant differences in knob rotation speed and duration in both conditions. These results demonstrate that the brain appears to weigh visual and vestibular cues equally during a visual–vestibular conflict of approximately equal speeds. These results are most consistent with the optimal cue integration hypothesis.
Peningkatan Kualitas Masyarakat Melalui Penerapan “Say CHSE” Dan Pembuatan Masker Tie Dye Di Era Covid-19, Kampung Situ Bolang
Authors: Lohjiwa Vyana , Darwis Riadi , Trihayuningtyas Endah , Sophian Tatang , Hutahaean Renalmon 
Published: October 2023

Kampung Wisata Situ Bolang is a community-based tourism area. In the past, Situ Bolang was a natural lake that became a tourist destination for community. Unfortunately, due to the impact of the toll road construction, the springs are blocked so there is no supply of lake water; the lake is converted into rice fields; now the community has lost their source of clean water; The occurrence of land conversion for housing, road access, and industry has changed the habit pattern of the farming community into unskilled labour. Behind the irony, it turns out that there is an opportunity that can be developed which is currently guarded by the community, namely Martial Arts of Nampon style. Nampon martial arts being so special because the first students are Ir. Soekarno (the first President of the Republic of Indonesia) and Moch. Natsir. In addition to martial arts, there are several people who like to paint, even the paintings have been marketed to the ASEAN region. As an effort to preserve community-based culture in the era of the COVID-19 Pandemic, it is necessary to increase community capacity through training in the application of the Cleanliness, Health, and Environmental Sustainability (CHSE) concept in the Situ Bolang Tourism Area, otherwise to push the potential of people who like to paint, it can be utilized in making painted masks/tie dye motifs as an alternative souvenirs from Situ Bolang.
Keywords: Community Enhancement; Situ Bolang; Nampon Martial Arts; CHSE; Tie Dye Masks
L’innovation : gageure ou fantasme ?
Authors: Cros Françoise 
Published: October 2023

L’innovation à l’école, on en parle depuis les années soixante, celles où la contestation était à l’ordre du jour et où le discours des alternatives sociales était entendu dans la crainte ou l’espoir d’un monde nouveau. Pourquoi cette émergence de la notion ? S’agit-il d’un affichage social particulier ? Qu’est-elle devenue ensuite ?
Le décrochage scolaire : une question sociale et institutionnelle
Authors: Glasman Dominique 
Published: October 2023

Le décrochage scolaire est un objet aux contours flous. On ne peut en l’état que se contenter d’hypothèses quant à l’identité des décrocheurs et aux processus à l’oeuvre.
Néanmoins, il ne semble pas y avoir de rupture radicale entre les lycéens qui décrochent et leurs pairs qui, quoique faiblement mobilisés par les activités scolaires, demeurent au sein des établissements.
Les enjeux de ce phénomène dépassent le seul public concerné. Le décrochage interroge l’institution dans son fonctionnement comme dans sa capacité à donner sens à l’expérience scolaire et à aider à l’orientation des jeunes.
Le numérique en éducation : au-delà de l’impact
Authors: Collin Simon 
Published: October 2023

Ce texte commence par questionner le « paradigme de l’impact » du numérique en éducation, en montrant qu’il peut induire certains biais. En élargissant le paradigme de l’impact, il est possible d’appréhender le numérique dans sa relation dynamique aux acteurs éducatifs et aux contextes sociaux et culturels dans lesquels il s’insère, et de révéler des enjeux importants, tels que les inégalités numériques, qu’une centration excessive sur les impacts du numérique tend à laisser dans l’ombre
Cahiers ou classeurs ? Le pouvoir d’un dispositif ordinaire
Authors: Chartier Anne-Marie 
Published: October 2023

L’article ne traite pas de dispositifs innovants, mais des supports ordinaires d’écriture à l’école primaire ; il montre, à partir de Foucault, comment le dispositif cahiers/classeurs structure le regard que les élèves portent sur les savoirs scolaires, leur hiérarchie, leurs valeurs, en adoptant spontanément les critères du collège. On voit ainsi que l’efficacité d’un dispositif repose sur le fait d’instituer des rapports de force entre les savoirs en les transformant en évidences naturelles, invisibles.
Association of Plant-Based Protein Intake with Cognitive Function in Adults with CKD
Authors: Perez Luis , You Zhiying , Kendrick Jessica 
Published: October 2023

Key Points

Higher plant protein intake was associated with higher cognitive scores in people with kidney disease.Future trials are needed to determine whether increasing plant protein intake improves measures of cognition in patients with kidney disease.

Background
Patients with CKD have accelerated cardiovascular and cognitive aging when compared with the non-CKD population. This cognitive decline contributes to excessive rates of physical and functional decline, reduced quality of life, and mortality in the CKD population. Mediterranean diets, a plant-forward diet, have been associated with positive cognitive performance in the general non-CKD population and with some beneficial outcomes in CKD. However, it is still unclear whether plant-based diets are associated with cognitive decline in patients with CKD.

Methods
Using the National Health and Nutrition Examination Survey 2011–2012 and 2013–14 data, we conducted a secondary analysis evaluating the relationship of plant-based and unprocessed plant protein with cognitive outcome measures in eligible participants aged 60 years and older. All data were extracted from the available National Health and Nutrition Examination Survey demographic, questionnaire, examination, and laboratory data. CKD was calculated and defined in participants as urine albumin to creatinine ratio ≥30 mg/g and/or eGFR <60 ml/min. In incremental models, we adjusted for total energy intake, age, sex, race/ethnicity, body mass index, total energy intake, diabetes, hypertension, education, smoking, and alcohol.

Results
Higher plant-based protein above median dietary intakes was significantly associated with higher executive function scores in participants with CKD (P < 0.05). For all patients and in those with CKD, plant-based protein was significantly associated (P < 0.05) with higher composite cognitive scores in nearly all statistical models. Higher unprocessed plant protein was significantly associated (P < 0.05) with higher composite cognitive scores in all categorical models.

Conclusions
Higher plant protein intake was a significant predictor of certain individual and composite cognitive score measures within the general and in the CKD population. Future interventional trials are needed to determine whether increasing plant-based protein intake improves measures of cognition in patients with CKD.