bluuebunny/crossref_metadata_2025_split huggingface dataset:
Full-Endoscopic Technique for Posterior Fossa Decompression in Chiari Malformation
Authors: Dolas Ilyas , Unal Tugrul Cem , Yorukoglu Ali Guven , Ruetten Sebastian , Dolen Duygu , Gulsever Cafer Ikbal , Sahin Duran , Aydoseli Aydin , Sencer Altay 
Published: October 2023

BACKGROUND AND IMPORTANCE:
Full-endoscopic techniques are well-described for spinal procedures. Although endoscopic-assisted techniques are reported for posterior fossa decompression (PFD) in Chiari malformation (CM), a full-endoscopic technique is yet to be reported in these patients. The aim of this study was to present and describe a full-endoscopic technique for PFD in patients with CM.

CLINICAL PRESENTATION:
Two patients diagnosed with CM were operated on by the full-endoscopic PFD technique. The patients consented to the procedure and to the publication of their image. An endoscope with an oval shaft cross-section with a diameter of 9.3 mm, a working length of 177 mm, a viewing angle of 20°, and a working channel of 5.6 diameters were used. Operative videos were recorded. The surgical steps were easily applied after the clear anatomic landmarks, such as the C1 posterior tubercle and the rectus capitis posterior minor muscles. The patients were followed up for 6 months. Both patients were symptom-free with a significant decrease in Visual Analog Scale score and a good functional outcome assessed by Chicago Chiari Outcome Scale after surgery without any complications.

CONCLUSION:
All the steps of the full-endoscopic technique for PFD described by the authors in their previous human cadaveric study were also feasible on patients with CM.
Direct Transverse Sinus Puncture for Transvenous Coil Embolization of Vein of Galen Malformations: Innovating Existing Techniques
Authors: Rangwala Shivani D. , Johnson Kristin , See Alfred P. , Smith Edward R. , Orbach Darren B. 
Published: October 2023

BACKGROUND AND IMPORTANCE:
Vein of Galen malformations (VOGMs) are complex arteriovenous malformations in neonates and young children. Recent advances in endovascular interventions have drastically improved treatment and clinical outcomes in what was previously high-morbidity, high-mortality disease. The high-flow shunt pathophysiology in VOGMs can lead to dynamic changes in the malformation angioarchitecture, and over time patients can develop jugular bulb stenosis. In the setting of inaccessible transvenous access to the malformation for endovascular embolization in cases where transarterial embolization is inadequate, a combined surgical and endovascular technique must be used. We present the first successful modern-day application of direct puncture through transverse sinus for transvenous embolization of a VOGM.

CLINICAL PRESENTATION:
We present 2 unique cases of complex VOGM malformations in patients who had previously undergone staged endovascular embolization for reduction of flow within the malformation. On follow-up, in both cases, there was development of severe sigmoid sinus and jugular bulb stenosis, increasing intracranial venous congestion and causing marked clinical deterioration. The stenosis prevented traditional transvenous access and treatment. We describe a direct puncture transverse sinus access using a burr hole approach for endovascular transvenous embolization in both cases with successful clinical outcomes.

CONCLUSION:
Direct access using burr hole craniotomy to the transverse sinus for transvenous endovascular embolization is a safe approach in the setting of severe jugular bulb stenosis for treatment of VOGMs. This technique can be done efficiently to achieve complete flow elimination in the malformation, in cases where that is called for, without significant risks or complications related to the approach.
SIN-3 acts in distinct complexes to regulate the germline transcriptional program in Caenorhabditis elegans
Authors: Robert Valerie J. , Caron Matthieu , Gely Loic , Adrait Annie , Pakulska Victoria , Couté Yohann , Chevalier Manon , Riedel Christian G. , Bedet Cecile , Palladino Francesca 
Published: October 2023

ABSTRACT
The transcriptional co-regulator SIN3 influences gene expression through multiple interactions that include histone deacetylases. Haploinsufficiency and mutations in SIN3 are the underlying cause of Witteveen–Kolk syndrome and related intellectual disability and autism syndromes, emphasizing its key role in development. However, little is known about the diversity of its interactions and functions in developmental processes. Here, we show that loss of SIN-3, the single SIN3 homolog in Caenorhabditis elegans, results in maternal-effect sterility associated with de-regulation of the germline transcriptome, including de-silencing of X-linked genes. We identify at least two distinct SIN3 complexes containing specific histone deacetylases and show that they differentially contribute to fertility. Single-cell, single-molecule fluorescence in situ hybridization reveals that in sin-3 mutants the X chromosome becomes re-expressed prematurely and in a stochastic manner in individual germ cells, suggesting a role for SIN-3 in its silencing. Furthermore, we identify histone residues whose acetylation increases in the absence of SIN-3. Together, this work provides a powerful framework for the in vivo study of SIN3 and associated proteins.
Comparison between premortem histopathology findings in rats with and without traumatic brain injury: prospective application in forensic medicine
Authors: Suryadi Taufik , Kulsum Kulsum 
Published: October 2023

Background: The aim of this study was to compare pre-mortem histopathology findings in rats with and without traumatic brain injury (TBI) and its prospective application in forensic medicine. Methods: This study involved 12 rats with 6 rats for each treatment group. This type of study is a laboratory experimental study with a case control design. The control group were rats that did not experience TBI. The case group was a group of rats with TBI. The subjects of this study were Rattus norvegicus rats, adult males, 4-8 weeks old, weighing 150-200 grams. On the 8th day after the rats experienced traumatic brain injury, the rats were then euthanized using the cervical dislocation method, after euthanasia the rats were given craniotomy and brain tissue was taken for histopathology examination. Results: The description of histopathology changes in the brain organs in the group of rat without TBI found that neuron cells looked normal although there were also degeneration (21.16 ± 2.56/FV), necrosis (5.75 ± 0.98/FV), apoptosis (2.91 ± 0.80/FV), congestion ( 0.91 ± 0.49/FV), inflammatory cells (4.58 ± 1.15/FV) and hemorrhage (2.41 ± 1.11/FV). Changes in the rat traumatic brain injury group showed a lot of damage to neuron cells in the form of degeneration (48.41 ± 3.27/FV), necrosis (36.66 ± 2.89/FV), apoptosis (18.91 ± 1.24/FV), congestion (2.50 ±0.31/FV), inflammatory cells (11.41 ± 1.71/FV) and hemorrhage (10.08 ± 2.17/FV). Based on the results of statistical analysis, it can be seen that in all parameters there is a significant difference (p ≤ 0.001). Conclusions: The premortem histopathology findings in rats with and without TBI which can be used for the benefit of forensic medicine in determining whether TBI is present or not. It is necessary to look more closely at the histopathology changes in the form of necrosis, apoptosis and hemorrhage.
“I get higher marks via BYOD”: A descriptive qualitative study on student experiences using BYOD e-assessments to enhance the dimensions of administration and support for learning excellence.
Authors: van As Janus , Brits Elizabeth Kanita 
Published: October 2023

Background: A Bring Your Own Device (BYOD) e-assessment strategy empowers students to use personal devices for digital exams, reducing the need for specialised facilities and enhancing learning excellence by simplifying by streamlining the administrative and support dimensions of the student experience. Despite its benefits, it remains underused. This study investigates student perceptions of BYOD for e-assessments within a Faculty of Medicine and Health Science. Methods: A descriptive qualitative approach was adopted, employing a survey with open-ended and Likert-scale questions to delve into student experiences. Results: The findings revealed that 82.7% of students had a positive experience due to the method's efficiency and convenience. However, 20.7% still preferred traditional pen-and-paper assessments. Various factors, such as technical difficulties, device quality and familiarity, and confidence in using technology, shaped these experiences. Students with older devices expressed worries about compatibility and performance. There were also issues related to connectivity and the specific device used. Interestingly, most students felt a sense of safety and were less stressed using a familiar device. However, those with outdated devices harboured performance concerns, and some lacked confidence in their technological skills. Conclusion: While BYOD for e-assessment offers a valuable means to enhance student experience and decrease administrative load, it is not a one-size-fits-all solution. Successful execution requires a mix of interventions, including faculty support, student training, and thoughtful planning. When implementing a BYOD e-assessment system, it is essential to consider student experiences and address their needs. Additionally, implementing BYOD for assessment requires multiple strategic actions to ensure effective integration. Furthermore, the study underlines the need for a comprehensive learning excellence approach that factors in student support and administration, affirming that technology can elevate the student experience. Therefore, conducting research on how technology can contribute to learning excellence warrants more research.
TRENDS AND PROBLEMS OF HUMAN RESOURCES DEVELOPMENT: THE ECOSYSTEM OF THE PERSONNEL APPROACH
Authors: Ashurbekov R. , Chernikova Ya. 
Published: October 2023

Currently, there is a decrease in the number of the population in the Russian Federation, the share of the able-bodied population is decreasing simultaneously with the level of employment. These trends play a role in the formation and use of human potential. Along with this, there are problems associated with the inability to build relationships and cooperation in the implementation of ecosystem projects. The ecosystem of personnel partnership, implemented through youth projects, will provide young people with jobs and education aimed at implementing new knowledge and skills. It includes the stages of origin, growth, maturity and rebirth or extinction, which determines the specific requirements for the professional qualities of the organization’s employees. The ecosystem of personnel partnership is developed based on the analysis of human resources development, which takes into account the trends occurring in modern society.
Strategic Heterogeneous Customers in a Transportation Station: Information and Pricing
Authors: Manou Athanasia , Canbolat Pelin G. , Karaesmen Fikri 
Published: October 2023

Problem definition: We consider pricing of services with strategic customers who have heterogeneous delay costs motivated by transportation systems. Customers are strategic decision makers who weigh the reward from the transport service against the waiting cost for the vehicle at a transportation station. Customers arrive at the station according to a Poisson process, and the vehicle visits the station according to a renewal process. We analyze the optimal price and the equilibrium for different levels of information available to customers. Methodology/results: We represent the service system as a stochastic clearing process, heterogeneity in delay cost as a random variable, and heterogeneity in rewards as a positive affine transformation of delay cost. For each information level, we identify the equilibrium behavior of customers and solve the revenue-maximization problem based on this equilibrium. The equilibrium turns out to be unique in each case, and it is of a threshold form in the sense that for each value of the information, it is best to join either for all types of customers, only for those who are sufficiently price sensitive, only for those who are sufficiently delay sensitive, or for none. The optimal fee is also unique in nontrivial cases. This enables us to perform comparisons across different information structures. Managerial implications: The effect of heterogeneity depends highly on model parameters as well as the available information. For a fixed fee, an increase in heterogeneity has a positive overall impact on the customer population, whereas the effect on the revenue can be positive (slow service at a high fee) or negative (fast service at a low fee). Unlike with fixed fee, for the optimal fee, an increase in heterogeneity can have a negative overall effect on customers. Ignoring heterogeneity can lead to a substantial opportunity loss for the system. Funding: A. Manou was supported by AXA Research Fund. P. G. Canbolat was supported by Marie Curie Career Integration Grant from the European Union’s Seventh Framework Programme (RISK) [FP7-PEOPLE-2013-CIG, Proposal No. 618853]. Supplemental Material: The e-companion is available at https://doi.org/10.1287/msom.2021.0116 .
Hybride Intelligenz: Zusammenarbeit mit KI-Assistenzsystemen in wissensintensiven Bereichen
Authors: Seufert Sabine , Meier Christoph 
Published: October 2023

ZusammenfassungMit KI-Agenten bzw. generativen KI-Systemen wie z. B. ChatGPT/GPT‑4 werden in absehbarer Zeit sehr leistungsfähige Assistenzsysteme breit verfügbar sein. Diese Assistenzsysteme können in verschiedensten Berufsfeldern und für verschiedenste Aufgaben eingesetzt werden. Damit stellen sich Fragen nach (1) den Optionen für die Gestaltung der Zusammenarbeit von Menschen und KI-Agenten, (2) dem Zusammenwirken von menschlicher und künstlicher Intelligenz und (3) den für eine erfolgreiche Zusammenarbeit mit intelligenten Assistenzsystemen erforderlichen Kompetenzen.Bisherige Modellierungen von KI-Kompetenzen bleiben recht allgemein und sind erkennbar nicht dahingehend spezifiziert, welches Wissen, welche Fertigkeiten und welche Einstellungen es für eine erfolgreiche Interaktion mit generativen KI-Assistenzsystemen wie beispielsweise ChatGPT, Midjourney oder GitHub Copilot braucht.Hier setzt der vorliegende Beitrag an, der auf einem deduktiv-konzeptionellen Vorgehen sowie auf der Sichtung und Analyse ausgewählter Literatur in den Forschungsfeldern ‚Human-Machine-Collaboration’ und „Hybrid Intelligence“ basiert.Im Hinblick auf die Zusammenarbeit von Menschen und KI-Agenten können nicht nur unterschiedliche Kooperationstypen und Stufen der Intensität der Zusammenarbeit unterschieden werden. Es können auch verschiedene Rollen für KI-Agenten als Teammitglieder unterschieden werden (z. B. Assistent, Koordinator, Macher, Experte).Menschen und KI-Agenten bringen in die Zusammenarbeit unterschiedliche Stärken ein und daraus resultiert eine „hybride Intelligenz“. Für die erfolgreiche Zusammenarbeit braucht es aber auch geeignete Rahmenbedingungen bzw. Haltungen und Einstellungen der beteiligten Menschen (z. B. ein „growth mindset“). Damit verbunden sind wichtige Management-Aufgaben, wie etwa das Etablieren von ethischen Leitlinien oder von „Growth Mindset Kulturen“ in Unternehmen und Organisationen.
Breastfeeding rates in England during the Covid-19 pandemic and the previous decade: Analysis of national surveys and routine data
Authors: Quigley Maria A. , Harrison Sian , Levene Ilana , McLeish Jenny , Buchanan Phyll , Alderdice Fiona 
Published: October 2023

Background
Few studies have compared breastfeeding rates before and during the pandemic using comparable data across time. We used data from two national maternity surveys (NMS) to compare breastfeeding rates in England before and during the pandemic.

Methods
Analysis was conducted using the NMS from 2018 (pre-pandemic; n = 4,509) and 2020 (during the pandemic; n = 4,611). The prevalence of breastfeeding initiation, and ‘any’ breastfeeding and exclusive breastfeeding (EBF) at 6 weeks and 6 months were compared between these surveys. Data were interpreted in the context of underlying trends in these prevalences from previous NMS (from 2010 and 2014), and annual routine data for England (from 2009–10 to 2020–21). Modified Poisson regression was used to estimate adjusted risk ratios (aRR) for the effect of birth during the pandemic (2020 versus 2018) on breastfeeding, with adjustment for sociodemographic and birth-related factors.

Results
Breastfeeding initiation and any breastfeeding at 6 weeks remained relatively constant in the NMS and the routine data. Birth during the pandemic was associated with a 3 percentage point decrease in EBF at 6 weeks in the NMS (aRR 0.92, 95%CI: 0.87, 0.98 for pandemic versus pre-pandemic), but a smaller decrease in the routine data. Birth during the pandemic was associated with a 3 percentage point increase in any breastfeeding at 6 months in the NMS (aRR 1.05, 95%CI: 1.00, 1.10). Breastfeeding varied across different groups of women in the NMS (i.e. marked inequalities), but the small changes observed between the pandemic and pre-pandemic NMS were broadly similar across the sociodemographic and birth-related factors examined (i.e. no change in inequalities).

Conclusion
Breastfeeding initiation and any breastfeeding at 6 weeks in England were unaffected by the pandemic, and the persistent inequalities in breastfeeding did not widen. Services should aim to reduce these inequalities in breastfeeding which have been documented since the 1970s.
Incidence of acute kidney injury (AKI) and outcomes in COVID-19 patients with and without antiviral medications: A retrospective study
Authors: Mousavi Movahed Seyed Majid , Akhavizadegan Hamed , Dolatkhani Fatemeh , Akbarpour Samaneh , Nejadghaderi Seyed Aria , Najafi Morvarid , Pezeshki Parmida Sadat , Khalili Noushabadi Akram , Ghasemi Hoomaan 
Published: October 2023

BackgroundAcute kidney injury is a complication of COVID-19 and is associated with severity. Despite no specific antiviral treatment strategy, lopinavir/ritonavir and remdesivir have been used. Data on the association between AKI and receiving antiviral agents with outcomes in hospitalized patients with COVID-19 is scarce. We aimed to determine the incidence of AKI and its outcomes in COVID-19 patients with and without antiviral medications.MethodsWe conducted a retrospective study on hospitalized adult patients with SARS-CoV-2 infection in a tertiary center. The primary endpoint was determining mortality, intensive care unit (ICU) admission, and length of hospitalization affected by AKI development using antiviral agents. The logistic regression method was used to explore the predictive effects of AKI and antiviral therapy on composite outcomes (i.e., mortality, ICU admission, and prolonged hospitalization) in four defined groups by AKI development/not and utilizing antivirals/not. We used IBM SPSS version 24.0 software for statistical analysis.ResultsOut of 833 COVID-19 patients who were included, 75 patients were treated with antiviral agents and developed AKI. There was a significant difference in the occurrence of AKI and using antiviral medications (p = 0.001). Also, the group using antiviral agents and the development of AKI had the highest rate of preexisting hypertension (p = 0.002). Of note, the group of patients who used antiviral agents and also developed AKI had the most remarkable association with our composite outcome (p<0.0001), especially ICU admission (OR = 15.22; 95% CI: 8.06–27.32).ConclusionsThe presence of AKI among COVID-19 patients treated with antiviral agents is linked to increased severity and mortality. Therefore, it is imperative to explore preventive measures for AKI development in patients receiving antiviral therapy. Larger-scale randomized controlled trials may be warranted to provide a more comprehensive understanding of these associations.
Activation of UBEC2 by transcription factor MYBL2 affects DNA damage and promotes gastric cancer progression and cisplatin resistance
Authors: Long Jiegen , Zhu Bin , Tian Tao , Ren Linfei , Tao Yong , Zhu Haitao , Li Dengwei , Xu Yonghong 
Published: October 2023

Abstract
Ubiquitin-conjugating enzyme E2 C (UBE2C) plays a carcinogenic role in gastric cancer (GC); yet, its role in cisplatin (DDP) resistance in GC is enigmatic. This study sought to probe into the impact of UBE2C on DDP resistance in GC and its concrete molecular mechanism in GC progression. Bioinformatics analysis was used to analyze differentially expressed mRNAs and predict upstream regulatory molecules in GC. Real-time quantitative reverse transcriptase polymerase chain reaction and western blot were used to detect the expression of UBE2C and MYB proto-oncogene like 2 (MYBL2). Dual luciferase and chromatin immunoprecipitation (ChIP) assays were used to verify the binding relationship. Cell counting kit-8 was used to detect cell viability and calculate IC50 values. Flow cytometry was used to detect the cell cycle. Comet assay was used to detect DNA damage. Western blot was used to detect the expression of DNA loss-related proteins (γ-H2AX, ATM/p-ATM). The knockdown of highly expressed UBE2C in GC cell lines could reduce cell viability, induce G2/M arrest, induce apoptosis, and promote DNA damage and DDP sensitivity. Bioinformatics analysis predicted that the substantially upregulated MYBL2 was an upstream transcription factor in UBE2C. The binding relationship between the UBE2C promoter region and MYBL2 was verified by dual luciferase and ChIP. Overexpression of UBE2C in the rescue experiment was found to reverse the inhibited GC progression and promoted DDP sensitivity brought by the knockdown of MYBL2. In conclusion, the MYBL2/UBE2C regulatory axis may be a potential way to overcome DDP resistance in GC.
Qualification and optimisation of a gas mixing apparatus for complex trace gas mixtures
Authors: Arendes Dennis , Amann Johannes , Tessier Cyril , Brieger Oliver , Schütze Andreas , Bur Christian 
Published: October 2023

Abstract
A gas mixing apparatus (GMA) can provide well-defined gas mixtures, which are necessary to calibrate gas sensors for quantitative measurements. This article presents a novel modular GMA and especially the representative measurements carried out to qualify and quantify its performance. New methods were developed to optimise the GMA’s settling speed and to enable self-monitoring. The GMA is able to provide up to 14 individual test gases, each in a large concentration range from sub-parts-per-billion to hundreds of parts-per-million. Additionally, the relative humidity can be set. The system is able to provide stable gas mixtures in approximately 6 min. The entire control software is realised in Python, which determines the control setpoints of all relevant system components based on the concentration input of the user. A major focus was placed on minimising the time of a gas mixture exchange to confirm design and additional software optimisation. Also, a number of techniques are shown for the analytical quantification of the system, including analysis of thermal desorption tubes by an accredited laboratory, showing maximal contaminations of e.g. only 4.18 ppb ethanol. Finally, self-monitoring of the system using photoionization detectors (PID) is demonstrated as an addition to flow readback for internal leakage detection.