bluuebunny/crossref_metadata_2025_split huggingface dataset:
EAACI/ENDA position paper on drug provocation testing
Authors: Barbaud Annick , Garvey Lene Heise , Torres Maria , Laguna Jose Julio , Arcolaci Alessandra , Bonadonna Patrizia , Scherer Hofmeier Kathrin , Chiriac Anca Mirela , Cernadas Josefina , Caubet Jean Christoph , Brockow Knut 
Published: December 2023

AbstractIn drug hypersensitivity, drug provocation testing (DPT), also called drug challenge, is the gold standard for investigation. In recent years, risk stratification has become an important tool for adjusting the diagnostic strategy to the perceived risk, whilst still maintaining a high level of safety for the patient. Skin tests are recommended before DPT but may be omitted in low‐risk patients. The task force suggests a strict definition of such low‐risk patients in children and adults. Based on experience and evidence from studies of allergy to beta‐lactam antibiotics, an algorithm on how to adjust DPT to the risk, and when to omit skin tests before DPT, is presented. For other antibiotics, non‐steroidal anti‐inflammatory drugs and other drugs, skin tests are poorly validated and DPT is frequently necessary. We recommend performing DPT with chemotherapeutics and biologicals to avoid unnecessary desensitization procedures and DPT with skin tests negative contrast media. We suggest DPT with anesthetics only in highly specialized centers. Specifics of DPT to proton pump inhibitors, anticonvulsants and corticosteroids are discussed. This position paper provides general recommendations and guidance on optimizing use of DPT, whilst balancing benefits with patient safety and optimizing the use of the limited available resources.
Spleen‐dedicated stiffness measurement performed well to rule out high‐risk varices in HBV‐related hepatocellular carcinoma
Authors: Cheng Xiao , Tang Yujun , He Qinjun , Song Jiankang , Wang Kunyuan , Li Hui , Huang Jing , Wang Weibin , Li Junying , Wang Haiyu , Tu Minghan , Chen Jinzhang , Yuan Guosheng , Kang Shuai , Liu Hongyan , Zhang Xiaoyong , Luo Wenfan , Ji Yali , Lan Xiaoqin , Zhou Ling , Lai Qintao , Luo Xiaoqin , Wu Qiaoping , Zhou Damei , Tan Yingqi , Chen Jinjun , Zhang Xiaofeng 
Published: December 2023

SummaryBackgroundEsophagogastroduodenoscopy (EGD) is required to screen for high‐risk varices (HRV) in patients with hepatocellular carcinoma (HCC), especially since overall survival rates have dramatically improved with new systemic therapies.AimTo assess the Baveno VI and Baveno VII algorithms' ability to rule out HRV in hepatitis B virus (HBV)‐related HCCMethodsWe prospectively enrolled consecutive patients with HBV related, compensated cirrhosis and newly diagnosed HCC who underwent liver stiffness measurement, spleen stiffness measurement (SSM) using a 100‐Hz shear wave frequency, and EGD.ResultsFrom September 2021 to August 2023, we enrolled 219 patients with HCC, with 107 (48.9%) Barcelona Clinic Liver Cancer (BCLC) A, 28 (12.8%) BCLC B and 84 (38.3%) BCLC C, respectively. HRV prevalence was 28.8% (63/219). Baveno VI criteria safely (HRV missing rate, 3.2%) avoided 27.4% unnecessary EGDs, while the Baveno VII algorithm avoided 49.3% with HRV missing rate at 7.9% (5/63). The SSM ≤40 kPa avoided 47.5% of EGDs safely (HRV missing rate, 4.8%), significantly better than the Baveno VI criteria (p < 0.001) and comparable to the Baveno VII algorithm (p = 0.390). The SSM ≤40 kPa safely avoided EGDs in patient subgroups within Milan criteria, with portal vein tumour thrombosis or BCLC B/C or candidates for systemic therapy.ConclusionsWe validated that the SSM ≤40 kPa using a 100‐Hz probe could safely eliminate more unnecessary EGDs than the Baveno VI criteria in patients with HBV‐related HCC. However, the efficacy of the Baveno VII algorithm in patients with HCC requires further investigation.
The work effectiveness and its influencing factors of child directors in China
Authors: Guan Qiujie , Zhang Shu , Zhao Fang 
Published: December 2023

AbstractImplementing the child director policy is an innovation in China's child protection practice, and the work of child directors aims to provide care and protection services for vulnerable children in communities and villages. According to the person–environment fit theory (i.e., needs–supplies fit), this study evaluated the work effectiveness of child directors and its influencing factors from environmental and personal perspectives. The results revealed that the supportive work environment (i.e., management, training, and supervision) and personal factors (i.e., professional competency and career identity) positively influenced the work effectiveness of child directors, and professional competency and career identity mediated the relationship between the supportive work environment and the work effectiveness. The findings provided evidence for improving the implementation of child director policy in the future.
Cardiovascular diseases after high‐dose chemotherapy and autologous stem cell transplant for lymphoma: A Danish population‐based study
Authors: Baech Joachim , Husby Simon , Trab Trine , Kragholm Kristian , Brown Peter , Gørløv Jette S. , Jørgensen Judit M. , Gudbrandsdottir Sif , Severinsen Marianne Tang , Grønbæk Kirsten , Larsen Thomas Stauffer , Wästerlid Tove , Eloranta Sandra , Smeland Knut B. , Jakobsen Lasse Hjort , El‐Galaly Tarec C. 
Published: December 2023

SummaryCardiovascular diseases, especially congestive heart failure (CHF), are known complications of anthracyclines, but the risk for patients undergoing high‐dose chemotherapy and autologous stem cell transplant (HDT‐ASCT) is not well established. With T‐cell therapies emerging as alternatives, studies of long‐term complications after HDT‐ASCT are warranted. Danish patients treated with HDT‐ASCT for aggressive lymphoma between 2001 and 2017 were matched 1:5 on sex, birth year and Charlson comorbidity score to the general population. Events were captured using nationwide registers. A total of 787 patients treated with HDT‐ASCT were identified. Median follow‐up was 7.6 years. The risk of CHF was significantly increased in the HDT‐ASCT population compared to matched comparators with an adjusted hazard ratio (HR) of 5.5 (3.8–8.1). The 10‐year cumulative incidence of CHF was 8.0% versus 2.0% (p < 0.001). Male sex, ≥2 lines of therapy, hypertension and cumulative anthracycline dose (≥300 mg/m2) were risk factors for CHF. In a separate cohort of 4089 lymphoma patients, HDT‐ASCT was also significantly associated with increased risk of CHF (adjusted HR of 2.6 [1.8–3.8]) when analysed as a time‐dependent exposure. HDT‐ASCT also increased the risk of other cardiac diseases. These findings are applicable for the benefit/risk assessment of HDT‐ASCT versus novel therapies.
Best practices, errors, and perspectives of half a century of plant translocation in Italy
Authors: D'Agostino Martina , Cao Pinna Luigi , Carboni Marta , Assini Silvia , Bacchetta Gianluigi , Bartolucci Fabrizio , Brancaleoni Lisa , Buldrini Fabrizio , Carta Angelino , Cerabolini Bruno , Ceriani Roberta Maria , Clementi Umberto , Cogoni Donatella , Conti Fabio , Crosti Roberto , Cuena‐Lombraña Alba , De Vitis Marcello , Di Giustino Attilio , Fabrini Giuseppe , Farris Emanuele , Fenu Giuseppe , Fiorentin Roberto , Foggi Bruno , Forte Luigi , Garfì Giuseppe , Gentili Rodolfo , Giusso Del Galdo Gian Pietro , Martinelli Valentino , Medagli Pietro , Nonis Domitilla , Orsenigo Simone , Paoli Luca , Pierce Simon , Pinna Maria Silvia , Rainini Franco , Ravera Sonia , Rossi Graziano , Schettino Aldo , Schicchi Rosario , Troìa Angelo , Varone Laura , Zappa Elena , Abeli Thomas 
Published: December 2023

AbstractConservation translocations are becoming common conservation practice, so there is an increasing need to understand the drivers of plant translocation performance through reviews of cases at global and regional levels. The establishment of the Italian Database of Plant Translocation (IDPlanT) provides the opportunity to review the techniques used in 186 plant translocation cases performed in the last 50 years in the heart of the Mediterranean Biodiversity Hotspot. We described techniques and information available in IDPlanT and used these data to identify drivers of translocation outcomes. We tested the effect of 15 variables on survival of translocated propagules as of the last monitoring date with binomial logistic mixed‐effect models. Eleven variables significantly affected survival of transplants: life form, site protection, material source, number of source populations, propagation methods, propagule life stage, planting methods, habitat suitability assessment, site preparation, aftercare, and costs. The integration of vegetation studies in the selection of suitable planting sites significantly increased the success of translocation efforts. Although posttranslocation watering had a generally positive effect on translocation outcome, other aftercare techniques did not always increase transplant survival. Finally, we found that how funds were spent appeared to be more important than the actual amount spent. Plant translocations in Italy and in the Mediterranean area should account for the complexity of speciation, gene flow, and plant migrations that has led to local adaptations and has important implications for the choice and constitution of source material.
Problems, causes, and reflections on exhibitions of document collection institutions in China: Triangulation of literature analysis and empirical study
Authors: Zhou Jingjing , Mao Ruohan , Huang Tingting 
Published: December 2023

AbstractExhibitions have become a major highlight of information communication and innovative services in Chinese libraries, archives, and local chronicles museums in recent years. However, many of these exhibitions have been hindered in “dialogue” with their audiences, leading to a limited impact. Hence, this study employed a triangulation approach, combining literature analysis and empirical study, to identify the existing problems of libraries, archives, and local chronicles exhibitions. On the one hand, perspectives were refined from previous studies through literature analysis to establish a research foundation for exhibition issues. On the other hand, nine institutions were selected for empirical study through importance‐performance analysis (IPA) in east, central, and west China, integrating audience perspectives into problematic space. Based on the triangulation evidence, the problems mainly focus on three aspects: architectural planning, exhibition business, and public services, whereas the causes of the problems include stereotypes, late start points, and so on. The root causes appear to lie in the failure to transform from the document center to the public center, and the imbalance of curatorial theory research as a constraint bottleneck. These findings are expected to be utilized to enhance the specialization of Chinese documentary exhibitions, which attempt to overcome the difficulties of audience understanding and realize the real value of documents and the communication function of the media, thus promoting an effective dialogue between exhibitions and audiences.
Experiences of telehealth among people receiving alcohol and other drug treatment during the COVID‐19 pandemic: Implications for future telehealth delivery
Authors: Woolley Jaimie , Savic Michael , Garfield Joshua B. B. , Petukhova Rachel , Manning Victoria , Lubman Dan I. , Barnett Anthony 
Published: December 2023

AbstractIntroductionThe novel coronavirus (COVID‐19) pandemic necessitated the rapid uptake of telehealth to deliver treatment for alcohol and other drug (AOD) concerns. However, little is known about how the move from in‐person to telehealth delivery impacted clients' experience of care. This qualitative study aimed to explore experiences of telehealth among people receiving alcohol and other drug treatment during the COVID‐19 pandemic, and their preferences regarding future telehealth care.MethodsParticipants were aged 34–66 years (M = 44 years, 60% male) and were recruited from Victorian AOD treatment services and consumer networks. A total of 20 semi‐structured interviews were analysed using thematic analysis.ResultsThree themes were identified: (i) experiences of the practical impacts of telehealth; (ii) experiences of telehealth interactions; and (iii) preferences for future telehealth. Contextual factors, including location and socioeconomic status, were found to impact clients' ability to access reliable telehealth with sufficient privacy. While telehealth was generally associated with increased treatment engagement (for a typically stigmatised population), participants noted varying effects on the therapeutic alliance. Although in‐person treatment was generally favoured, participants often valued telehealth as a modality to provide empathic care during the pandemic. Participants expressed a preference for a hybrid treatment model in the future, in which they could choose a combination of telehealth and in‐person services.ConclusionClient and clinician information and training are vital to improve the future delivery of telehealth for AOD treatment.
Outcomes in Kaposi's sarcoma‐associated herpesvirus ‐associated primary effusion lymphoma and multicentric Castleman's disease in patients with human immunodeficiency virus (HIV) in a safety‐net hospital system
Authors: Lopez Melanie , Kainthla Radhika , Lazarte Susana , Chen Weina , Nijhawan Ank E. , Knights Sheena 
Published: December 2023

AbstractObjectiveTo describe cases of Kaposi's sarcoma‐associated herpesvirus (KSHV)‐associated multicentric Castleman's disease (MCD) and primary effusion lymphoma (PEL) in patients with HIV from a large, safety‐net hospital system in Dallas, Texas, USA.MethodsWe conducted a retrospective review of patients with HIV‐associated PEL and/or MCD.ResultsTwelve patients with PEL and 10 patients with MCD were identified. All patients were male and 17 of 20 were men who have sex with men; 66.7% of PEL patients and 50% of MCD patients had concurrent KS at the time of diagnosis; 42% of patients with PEL and 20% of patients with MCD died during the follow‐up period. We noted improved survival in our cohort compared to previous studies, particularly in our PEL patients with a median survival of 11.4 months compared to 3–6‐month median survival historically. Median follow‐up time for MCD patients was 17.5 months. This improved survival is despite suboptimal antiretroviral therapy (ART) adherence at diagnosis, with only 50% of patients on ART at the time of MCD/PEL diagnosis.ConclusionThese data highlight the importance of early recognition of PEL and MCD, and the larger‐scale efforts needed to better understand the pathogenetic drivers of clinical outcomes in patients affected by KSHV‐related diseases.
Abdominal inflammatory myofibroblastic tumour: Clinicopathological and molecular analysis of 20 cases, highlighting potential therapeutic targets
Authors: Vernemmen Astrid I P , Samarska Iryna V , Speel Ernst‐Jan M , Riedl Robert G , Goudkade Danny , de Bruïne Adriaan P , Wouda Siep , van Marion Arienne M , Verlinden Ivana V , van Lijnschoten Ineke , Friederich Pieter , Winnepenninckx Véronique J L , zur Hausen Axel , Sciot Raf M E , van den Hout Mari F C M 
Published: December 2023

AimsInflammatory myofibroblastic tumour (IMT) is a rare mesenchymal neoplasm of intermediate malignant potential, occurring at any age and at multiple sites. Epithelioid inflammatory myofibroblastic sarcoma (EIMS) is an aggressive subtype of IMT, typically involving the abdomen. Most IMTs harbour kinase gene fusions, especially involving ALK and ROS1, but 20–30% of IMTs show no detectable translocations. The aim of this study is to further delineate clinicopathological and molecular characteristics of abdominal IMT and discover potential new therapeutic targets.Methods and resultsIn 20 IMTs, including four EIMS, RNA fusion analysis was performed, followed by multiplex DNA analysis if no ALK or ROS1 fusion was detected. Fourteen IMTs (70.0%) had an ALK translocation and the fusion partner was identified in 11, including a RRBP1::ALK fusion, not previously described in classical (non‐EIMS) IMT. RANBP2::ALK fusion was demonstrated in all EIMS. One IMT had a ROS1 fusion. In all ALK/ROS1 translocation‐negative IMTs mutations or fusions – as yet unreported in primary IMT – were found in genes related to the receptor tyrosine kinase (RTK)/PI3K/AKT pathway. Three of four patients with EIMS died of disease [mean survival 8 months (4–15 months)], whereas only one of 14 classical IMT patients succumbed to disease [mean follow‐up time 52 months (2–204 months); P < 0.01].ConclusionThis study shows the wide clinical spectrum of abdominal IMTs and affirms the poor prognosis of EIMS, raising discussion about its status as IMT subtype. Furthermore, the newly detected alterations of the RTK/PI3K/AKT pathway expand the molecular landscape of IMTs and provide potential therapeutic targets.
Treating symmetric buyers asymmetrically
Authors: Banerjee Shraman 
Published: December 2023

AbstractWe investigate a finite‐horizon dynamic pricing problem of a seller under limited commitment. Even when the buyers are ex ante symmetric to the seller, the seller can charge different prices to different buyers. We show that under the class of posted‐price mechanisms this asymmetric treatment of symmetric buyers strictly revenue‐dominates symmetric treatment. The seller implements this by using a priority‐based deterministic tie‐breaking rule instead of using a random tie‐breaking rule. The effect of asymmetric treatment on revenue increment increases monotonically as we increase the time horizon of the game.
Using museum collections to explore predator–prey relationships in snail‐eating beetles (Carabidae: Cychrini)
Authors: Keiser Carl N. , Davidson Robert , Pearce Timothy A. 
Published: December 2023

AbstractThe vast majority of species interactions in nature go unnoticed because they occur under circumstances unamenable to observation. This is unfortunate, as our understanding of trophic ecology is predicated on our ability to quantify the nature and magnitude of species interactions. Here, we use specimens from museums and private collections to estimate prey breadth and morphological patterns between predator and prey pairs of the malacophagous Cychrini beetles collected alongside their snail prey. We identified each pair, measured a series of morphological traits on each, and tested for relationships between the morphological characteristics of beetles and the snails they were found eating. Of 38 specimen pairs, we identified 12 species of Cychrini beetles from two genera (Scaphinotus and Cychrus) eating 22 species of snail prey from 12 genera and ranging from 1 to 9 species of snail prey per beetle species. We found 29 unique predator–prey species pairs. Irrespective of species identity, we found that female beetles were discovered eating larger snails compared to male beetles. We detected two trends in which larger beetles were found eating snails with relatively larger aperture openings, and beetles with more slender body shapes (longer, thinner mandibles, heads, and pronota) were found eating snails whose shells had relatively smaller aperture openings. This suggests that, even within the carabid tribe Cychrini, variation in the cychrine body form may influence prey availability. This study provides the most comprehensive list to date of predator–prey pairs in this understudied group of beetles and also demonstrates the utility of museum collections for documenting cryptic species interactions.
Identification of eight genomic protective alleles for mitochondrial diabetes by Kinship‐graph convolutional network
Authors: Wang Jiahao , Yan Dandan , Cui Haoyue , Zhang Rong , Ma Xiaojing , Chen Luonan , Hu Cheng , Wu Jiarui 
Published: December 2023

ABSTRACTAimsNearly 85% of maternally inherited diabetes and deafness (MIDD) are caused by the m.3243A>G mutation in the mitochondrial DNA. However, the clinical phenotypes of MIDD may also be influenced by the nuclear genome, this study aimed to investigate nuclear genome variants that influence clinical phenotypes associated with m.3243A>G mutation in MIDD based on whole‐genome sequencing of the patients belonging to pedigrees.Materials and MethodsWe analyzed a whole‐genome sequencing (WGS) dataset from blood samples of 38 MIDD patients with the m.3243A > G mutation belonging to 10 pedigrees, by developing a Kinship‐graph convolutional network approach, called Ki‐GCN, integrated with the conventional genome‐wide association study (GWAS) methods.ResultsWe identified eight protective alleles in the nuclear genome that have protective effects against the onset of MIDD, related deafness, and also type 2 diabetes. Based on these eight protective alleles, we constructed an effective logistic regression model to predict the early or late onset of MIDD patients.ConclusionsThere are protective alleles in the nuclear genome that are associated with the onset‐age of MIDD patients and might also provide protective effects on the deafness derived from MIDD patients.
Interventions to promote the implementation of pressure injury prevention measures in nursing homes: A scoping review
Authors: Yang L. F. , Mu J. X. , Zhang J. , Zang S. , Zhang L. , Qi J. H. , Ni C. P. , Liu Y. 
Published: December 2023

AbstractAimsTo identify studies and the content of the interventions that have facilitated the implementation of pressure injury (PI) prevention measures in nursing home settings.Design and MethodA scoping review methodology was employed. The author has carried out the following steps successively: Identified this scoping review's questions, retrieved potentially relevant studies, selected relevant studies, charted the data, summarised the results, and consulted with stakeholders from nursing homes in China.Data SourcesSix electronic databases and three resources of grey literature—PubMed, CINAHL, Web of Science Core Collection, Embase, Cochrane Central Register of Controlled Trials, Psych INFO, Open Grey, MedNar, ProQuest Dissertations, and Theses Full Texts were searched from January 2002 through May 2022.ResultsForty articles were included, among which the primary interventions were quality improvement, training and education, evidence‐based practice, device‐assisted PI prophylaxis, nursing protocols, and clinical decision support systems. Twenty‐three outcome indicators were summarised in 40 articles, which included 10 outcome indicators, seven process indicators, and six structural indicators. Furthermore, only five articles reported barriers in the process of implementing interventions.ConclusionThe common interventions to promote the implementation of PI prevention measures in nursing homes are quality improvement, training, and education. Relatively limited research has been conducted on evidence‐based practice, clinical decision support systems, device‐assisted PI prophylaxis, and nursing protocols. In addition, there is a paucity of studies examining the impediments to implementing these measures and devising targeted solutions. Therefore, it is recommended that future studies include analysis and reporting of barriers and facilitators as part of the article to improve the sustainability of the intervention.ImpactThis article reminds nursing home managers that they should realise the importance of implementation strategies between the best evidence of PI prevention and clinical practice. Also, this review provides the types, contents, and outcome indicators of these strategies for managers of nursing homes to consider what types of interventions to implement in their organisations.TRIAL AND PROTOCOL REGISTRATIONThe protocol of this scoping review was published as an open‐access article in June 2022 (Yang et al., 2022).