bluuebunny/crossref_metadata_2025_split huggingface dataset:
FORMATION OF AN INCLUSIVE APPROACH IN THE EDUCATION OF CHILDREN WITH SPECIAL EDUCATIONAL NEEDS (UKRAINIAN EXPERIENCE)
Authors: Shostak Olha , Nikolenko Iryna , Sereda Iryna , Pushkarova Tamara , Potapiuk Liliia 
Published: October 2023

The purpose of the study is to rethink the standardized course curriculum in accordance with an inclusive approach. The method of analyzing secondary data made it possible to put forward the hypothesis that a modern Ukrainian school should be both regular and adapted to the needs of all students who attend it, considering their differences and special educational needs. Results. The article analyzes the formation of an inclusive approach to the education of children with special educational needs in Ukrainian education based on the professional activity of a teacher's assistant (accompanying person), reveals the dilemmas faced by a school attendant in search of his professional identity, which puts him on the verge of another profession - the profession of a teacher. The novelty of the work lies in the disclosure of the problems of interprofessional relations and the field of activity of teacher assistants, which has not yet been disclosed. Based on the experience of the focus group, the author presents her own approach to inclusive education of children with special educational needs. Conclusions. The analysis has revealed a diverse typology of teacher assistants' positions in inclusive schools in Ukraine, which reflects the delimitation of territories and borders, which complicates cooperation. It is recommended to create a national reference system of skills for teacher assistants to clearly define their scope of work in working with children with special educational needs and establish joint work trajectories with teachers. This will help to integrate knowledge, skills, and attitudes across the education sector, improve their performance and change their skills.
Life Dedicated to Science. On the Occasion of the 90th Anniversary of the Honored Scientist of the Russian Federation, Corresponding Member of the RAMS, Professor B.A. Nikityuk
Authors: Alexeeva N. T. , Klochkova S. V. , Nikityuk D. B. 
Published: October 2023

The article describes the main stages of the life path and scientific creativity of Doctor of Medical Sciences, professor, corresponding member of the Russian Academy of Medical Sciences Boris Aleksandrovich Nikityuk (1933–1998), who made a significant contribution to the development of domestic human anatomy. Scientific interests of B.A. Nikityuk were diverse. He conducted research in the field of developmental and environmental anatomy, sports morphology, medical and biological anthropology. His studies in the field of developmental genetics are widely known. Boris Aleksandrovich was one of the most successful developers of the acceleration doctrine, formulated its laws, developed methods and approaches for determining biological age. He was the first to formulate the basic laws of growth and development. The contribution of B.A. Nikityuk is generally recognized in the development of constitutional science. He formulated ideas about the local constitution, the reactivity of structures in connection with the characteristics of growth and development. The result of the valiant work of Professor B.A. Nikityuk became the founder of a scientific school of anatomists. Boris Alexandrovich's students continue to develop his scientific ideas up to this day.
Immunohistochemical Characteristic of Intratesticular SARS-CoV-2 Invasion
Authors: Demyashkin G. A. , Kogan E. A. , Demura T. A. , Boldyrev D. V. , Vadyukhin M. A. , Zharkov N. V. 
Published: October 2023

Based on studies on the effect of SARS-CoV-2 on tissues, not only pulmonary invasion but an impaired testicular function also were revealed. In single studies on small samples of patients, an increase in the number of apoptotic cells, CD138+ plasma cells, CD3+ T-lymphocytes, CD20+ B-lymphocytes, CD68+ macrophages in the interstitial tissue was found. However, a comprehensive morphological and immunohistochemical study has not been performed on a significant cohort of patients. Thus, the study of the mechanisms of influence of SARS-CoV-2 on spermatogenesis remains relevant.The aim of the study was to carry out an immunohistochemical evaluation of spermatogenesis disorders in SARS-CoV-2 invasion.Material and methods. For the first time, a cohort of COVID-19-positive patients was collected (n=69). The autopsy material was prepared for morphological, morphometric, and immunohistochemical analysis, and the index of spermatogenesis was calculated to assess the degree of hypospermatogenesis. The invasion of SARS-CoV-2 was studied by immunohisto-chemical method with antibodies to the spike protein, the nucleocapsid protein of the SARS-CoV-2 virus, and angiotensin-converting enzyme type 2 (ACE2).Results. In the morphometric study of the testicles of patients with COVID-19, a decrease in the degree of spermatogenesis was observed. Based on the morphological and morphometric analysis, as well as the decrease in the spermatogenesis index, it is highly likely that in patients with confirmed coronavirus infection over 45 years of age, the identified pathomorphological changes were more pronounced than in young people. An immunohistochemical study revealed S-protein- and nucleocapsid-positive germ cells, as well as an increase in the number of ACE2-positive germ cells, which indicates the invasion of SARS-CoV-2 into them. Conclusion. The immunophenotypic characteristics of the testicles of patients with a new coronavirus infection indicates the viral load of SARS-CoV-2, estimated by the amount of S-protein-, nucleocapsid- and ACE2-positive germ cells. The revealed morphological and immunohistochemical patterns most likely indicates the development of COVID-19-associated orchitis.
Remodeling of the Blood-Air Barrier Components in the Landscape of the Far North
Authors: Margaryan A. V. , Rashevskikh O. V. , Shidin V. A. , Matvienko V. V. 
Published: October 2023

The aim of the study was to evaluate the structural and functional changes in the components of the respiratory department of the lungs during the stay of experimental animals in the conditions of the Far North.Material and methods. The experiments were carried out on white outbred male rats 140–160 g by mass on the 7-, 15- and 30th days of stay in the conditions of northern latitudes – in Kogalym (62° 26′ N and 74° 48′ E). The structural components of the blood-air barrier were studied using light microscopy, transmission and scanning electron microscopy. The thickness of cytoplasmic processes of type I pneumocytes, cytoplasmic processes of endotheliocytes of capillaries and basement membranes was determined.Results. During all periods of stay of animals in the conditions of the Far North, thickening of the cytoplasmic processes of type I pneumocytes was noted, while the thickness of the cytoplasmic processes of endotheliocytes was significantly increased on the 7th day (p<0,032) and reached control values by the 15th day. During these periods, interstitial edema of the walls and transudate exudation in the lumen of the alveoli, multivesicular and osmophilic lamellar bodies in the cytoplasm of type II pneumocytes were observed, followed by surfactant release into the lumen of the alveoli according to the merocrine type. Later, in the conditions of the Far North, there was a tendency to decrease the main indicators of the blood-air barrier. There were single blood cells in the lumen of the alveoli, Kohn pores between the alveoli, and the merocrine type of surfactant release into the lumen of the alveoli was preserved in type II pneumocytes.Conclusion. As a result of the research, it was established that in the early periods of the animals' stay in the conditions of the Far North, there is an increase in the main components of blood-air barrier (cytoplasmic processes of type I pneumocytes, basal membranes and capillary endotheliocytes). In the early stages of animal adaptation, the phenomena of interstitial edema of the walls with transudation into their lumen are noted in individual alveoli. By the 30th day, there is a tendency to decrease the main indicators of the blood-air barrier compared to previous terms, but they do not reach the control values; the surfactant yield in the apical part of type II pneumocytes by the merocrine type is preserved.
Morphological and Functional Changes in Gum Tissues During Intoxication with Thiram Followed by Correction with Vitamin C and Silybum Extract
Authors: Mishina E. S. , Korolev V. A. , Fel'ker E. V. , Mnikhovich M. V. 
Published: October 2023

The widespread use of pesticides can lead to disruption of the ecological balance between the external environment and the human body, provoking the development of oxidative stress, which leads to an increase in toxic forms of damage to organs and systems of the macroorganism. The present study shows the effect of subchronic intoxication with the fungicide tiram on the morphological and functional state of gum tissues, as well as the use of plant antioxidants of vitamin C and silybum extract to stop the inflammatory process and to increase the regenerative potential of gum structural components.The aim was to study of morphofuncmorphofunctional changes in gum tissue during subchronic intoxication with the fungicide tiram and correction with vitamin C and silybum extract.Material and methods. The experiment was performed on 150 male Wistar rats, which were orally administered the fungicide thiram for 28 days, followed by antioxidant therapy. Morphofunctional changes in the mucosal epithelium and the cellular composition of the subepithelial layer were analyzed to assess the severity of inflammatory changes in histological preparations. Fibroblastic differon cells, macrophages and inflammatory cells of granulocytes and lymphocytes were differentiated by karyological signs, and the thickness of the epithelial layer, the areas occupied by the fibrous, vascular and cellular components were measured.Results. According to the results of the morphological and morphometric analysis, pathomorphological changes in the gum structure caused by pesticide intoxication were reliably proven. After the use of antioxidants, there was a significant decrease in inflammatory processes in non-resident cells, the number of blood vessels in the lamina propria, as well as interstitial edema in it. Reparative processes were manifested by the migration of fibroblastic cells, the initiation of collagenogenesis, and an increase in the fibrous component.Conclusion. Thus, the effect of using silybum extract and vitamin C as a means of normalizing the morphofunctional state of gum tissue after thiram intoxication has been shown.
The Role of Some Free-Ranging Animals in the Transmission of Multi-Host Species of Cryptosporidium Spp.
Authors: Mirzaghavami Mehran , Sadraei Javid , Pirestani Majid , Bahadory Saeed 
Published: October 2023

Background: We aimed to characterize Cryptosporidium spp. in rats, cats, pigeons, and crows.
Methods: Fifty-five animal origin Cryptosporidium spp. genome were identified, genotyped and confirmed by nested PCR and of RFLP-PCR analysis as well as sequenced based on 18s rRNA and gp60 genes in Tehran (2012-2019). Finally, the phylogenetic analysis was performed by MEGA software (version 7).
Results: By the molecular method, Cryptosporidium spp. were detected in 24 (15.2%), 15 (15%), 2 (2%) and 13 (13%) cases of wild rats, cat, pigeon, and crow, respectively. Among the identified species by the RFLP pattern, most isolates were identified as C. parvum (24/157) 17.8% in rats, (15/100) 15% in cats, (13/100) 13%in crew and (2/100) 2% in pigeons; and the rest of the cases were C. muris and C. felis. The results of sequencing did not prove the existence of C. parvum, C. felis, C. muris, and rat genotype. Subtyping of C. parvum was indicated that the dominant subtype family belongs to the IId family and the subtype A20G1 was the most common subtype detected in all hosts while A19G1 was detected in one isolate of cat and pigeon.
Conclusion: Free-ranging animals are infected by species/subtype of Cryptosporidium, which can infect humans. This shows by itself the hygienic importance of the free-ranging animals in urban ecosystems. In the transmission of human cryptosporidiosis, the multi-host Cryptosporidium species such as C. parvum, C. felis, and C. muris can be transferred potentially from these animals to humans.
Przestępstwo oraz wykroczenie skarbowe firmanctwa (art. 55 k.k.s.) w kontekście znamion ustawowych
Authors: Wróbel Adam 
Published: October 2023

Czyn zabroniony firmanctwa ujęty w przepisach kodeksu karnego skarbowego przyjmuje dwie postaci czynu zabronionego: przestępstwa skarbowego (art. 55 §§ 1 i 2 k.k.s.) oraz wykroczenia skarbowego (art. 55 § 3 k.k.s.). Istotą firmanctwa, jak wskazuje się w doktrynie, „jest prowadzenie działalności gospodarczej w sposób zakamuflowany lub też ukrywanie rzeczywistych jej rozmiarów z wykorzystaniem do tego podstawionego podmiotu, co naraża podatek na uszczuplenie” (F. Prusak); sprawca, realizując określony w art. 55 k.k.s. delikt, posługuje się imieniem i nazwiskiem, nazwą lub firmą innego podmiotu i naraża podatek na uszczuplenie. Przedmiotem omawianego czynu zabronionego jest interes finansowy Skarbu Państwa, jednostek samorządu terytorialnego – interes fiskalny państwa – oraz Unii Europejskiej (indywidualny przedmiot ochrony), a także wtórnie, jako uboczny przedmiot ochrony, legalny porządek rejestrowy przedsiębiorców, co wywieść można także z kontekstu poglądów wyrażanych w literaturze przedmiotu. Firmantem, tzn. sprawcą ujętym w definicji art. 55 § 1 k.k.s., może być jedynie podatnik prowadzący działalność gospodarczą określoną w art. 3 pkt 9 Ordynacji podatkowej, na co również zwraca się uwagę w doktrynie oraz judykaturze. Omawiane skarbowe przestępstwo lub wykroczenie ma charakter indywidualny, może zostać popełnione wyłącznie umyślnie, w formie działania (po stronie firmanta), w zamiarze bezpośrednim. Pod rozwagę zostaje poddany postulat, aby w wypadku mniejszej wagi, jeżeli kwota podatku narażonego na uszczuplenie jest małej wartości, czyn z art. 55 § 1 k.k.s. był klasyfikowany jako wykroczenie skarbowe.
Football Passing Training Model Based on Game for Children (10-12 Years)
Authors: Sakti Chandra Prima , Siregar Nofi Marlina , Sulaiman Iman 
Published: October 2023

The purpose of this study was to produce game based football passing training model for kids (10-12 years olds) that can be applied in the exercise as well as football school or football club. This training model is expected to help trainers during the training session, especially in passing material. This study uses the ADDIE method. The result of the study resulted in a product in the form of game based football passing training model for kids (10-12 years olds) that was validated by three football experts as many as 8 models of ball possession method. Data were collected through documentation, interviews, and observations. Data analysis was carried out by descriptive qualitative and quantitative methods. The result of the study were in the form of a game based football passing training model book for kids (10-12 years olds). The football passing training model can effectively improve the football passing skill of the kids athlete at the football school or football club. Based on the results of the study, it is proven that the football passing training model for kids (10-12 years olds) has been declared valid and effective and can be applied to kids (10-12 years olds).
Efficient Storage and Analysis of Videos through Motion-Based Frame Removal
Authors: R Akash , Anderson Leandra Shania 
Published: October 2023

Abstract
The storage and analysis of CCTV footage pose a significant challenge in modern surveillance systems. This paper presents an innovative and modern solution for efficient storage optimization and analysis through motion-based frame removal techniques. By leveraging the OpenCV library redundant frames are removed, resulting in substantial storage reduction without losing important motion events. The methodology uses Python’s OpenCV library with optional technologies such as Django, SQLite, and Bootstrap, ensuring reliability, scalability, usability, and effective data visualisation. Experimental results have demonstrated the efficacy across different camera setups in different environments and their ability to preserve critical information. The approach offers a practical solution for decreasing cost, improving analysis efficiency, and enhancing usability. This research contributes to the field of CCTV surveillance by providing a practical and industry-oriented solution. The findings inspire further improvements in storage optimization and pave the way for more intelligent surveillance systems.
Sex differences and individual variability in the captive Jamaican fruit bat (Artibeus jamaicensis) intestinal microbiome and metabolome
Authors: Riopelle Jade C , Shamsaddini Amirhossein , Holbrook Myndi G , Bohrnsen Eric , Lovaglio Jamie , Cordova Kathleen , Hanley Patrick , Lon Kendall V , Bosio Catherine M , Schountz Tony , Schwarz Benjamin , Munster Vincent J , Port Julia R 
Published: October 2023

Abstract
Although the intestinal microbiome plays an important role in mammalian health, disease, and immune function, it has not been well characterized in bats, the reservoir hosts of several highly pathogenic viruses. Here, we describe a pipeline to investigate the intestinal microbiome of captive Jamaican fruit bats (Artibeus jamaicensis). We observed a high degree of individual variation in addition to sex- and cohort-linked differences. The intestinal microbiome drove intestinal metabolite composition, possibly contributing to differences in immune status. This work provides a basis for future infection and field studies to examine in detail the role of the intestinal microbiome in antiviral immunity.
Cross-cultural adaptation and validation of the PIDAQ questionnaire in Chilean adolescents with oral malocclusion
Authors: Gonzalez Humberto , Ortuño Duniel , Macherone Catalina , Zedan Yazmin , Torres Maria Ignacia 
Published: October 2023

Abstract
Objective: Psychosocial Impact of Dental Aesthetics Questionnaire (PIDAQ) is a useful index to assess aspects of oral malocclusion that impact individuals' oral health-related quality of life. This study aimed to validate the cross-cultural adaptation and equivalence of the PIDAQ questionnaire to the language of the Chilean adolescent population.
Methods: We used the framework of the Guidelines for the Transcultural Adaptation Process of self-reports and the Manuals for a language inclusive for the transcultural adaptation of the PIDAQ. The instrument was tested on 32 Chilean adolescents with oral malocclusion between 11 and 17 years of age. We evaluated equivalence considering criterion, content, and construct validity according to COSMIN methodology and validated by Cronbach's alpha statistical test. A total of 23 items in the questionnaire were tested according to how clear and understandable the questions were to the reader and according to a Likert scale graduated in: not at all clear, unclear, unclear, clear, or very clear. For temporal stability, we calculated intraclass correlation coefficients (ICC).
Results: We obtained an acceptable reliability with a Cronbach's Alpha of 0.951 for the total questionnaire. The questions grouped according to the dimensions of dental self-confidence, social impact, psychological impact, and esthetic concern obtained a Cronbach's Alpha of 0.955, 0.947, 0.946 and 0.939, respectively. The questionnaire showed high temporal stability at the test-retest with a total ICC of 0.907 (0.885-0.913).
Conclusion: The cross-cultural adaptation of the PIDAQ questionnaire achieved equivalence with the original instrument and obtained reliable criterion, content, and construct validity in Chilean adolescents.
Perceptions of TB-HIV Comorbidity among the Nomads in Adamawa State, Nigeria
Authors: Abdulkarim Suraj , John Stephen , Garba Tomon , Basason Hunpiya , Balogun Paul , Kuye Joseph 
Published: October 2023

Abstract

The recalcitrance of Mycobacterium tuberculosis (MTB) to eradication was related to achieving a nonreplicating (dormant) state and the increasing global burden of HIV coinfection. Consequently, understanding the knowledge and perception of the population at risk of tuberculosis-HIV infection is essential to designing a strategy of intervention embraced by the target population. A cross-sectional study was conducted among Nomads in Adamawa State, Nigeria. A multistage sampling technique was employed to recruit consented participants. Self-administered questionnaires were used to gather the required information from 4 nomadic schoolteachers in each selected school. Data were entered into a Microsoft Excel sheet where trends and tables of collated data were developed. The findings show that only 13.5% of the participants expressed the correct perceptions of the complementary relationship between HIV and TB. More people in government employment (35%) understand the coexisting relationship of TB-HIV infections. At the same time, cattle herders and crop farmers who practice the prevalent occupation lack knowledge of TB-HIV relatedness. Across gender, only a proportion of males (14.8%) than females (10.5%) were more likely to show an understanding of the complementary association of HIV and TB, and this difference showed statistical significance (p = 0.0001). In conclusion, male gender, education at a degree or professional level, and employment with the government are factors associated with positive perceptions of TB/HIV relatedness. Thus, there is a need to intensify communication to educate Nomads on HIV and TB-related issues.
Prevention of neointimal hyperplasia after coronary artery bypass graft via local delivery of sirolimus and rosuvastatin: network pharmacology and in vivo validation
Authors: Ryu Ji-yeon , Jang Eui Hwa , Kim Jung-Hwan , Lee JiYong , Youn Young-Nam 
Published: October 2023

Abstract
Background
Coronary artery bypass graft (CABG) is generally used to treat complex coronary artery disease. Treatment success is affected by neointimal hyperplasia (NIH) of graft and anastomotic sites. Although sirolimus and rosuvastatin individually inhibit NIH progression, the efficacy of combination treatment remains unknown.
Methods
We identified cross-targets associated with CABG, sirolimus, and rosuvastatin by using databases including DisGeNET and GeneCards. GO and KEGG pathway enrichment analyses were conducted using R studio, and target proteins were mapped in PPI networks using Metascape and Cytoscape. For in vivo validation, we established a balloon-injured rabbit model by inducing NIH and applied a localized perivascular drug delivery device containing sirolimus and rosuvastatin. Outcomes were evaluated at 1, 2, and 4 weeks-post-surgery.
Results
We identified 115 shared targets between sirolimus and CABG among databases, 23 between rosuvastatin and CABG, and 96 among all three. TNF, AKT1, and MMP9 were identified as shared targets. Network pharmacology predicted the stages of NIH progression and the corresponding signaling pathways linked to sirolimus (acute stage, IL6/STAT3 signaling) and rosuvastatin (chronic stage, Akt/MMP9 signaling). in vivo experiments demonstrated that the combination of sirolimus and rosuvastatin significantly suppressed NIH progression. This combination treatment also markedly decreased the expression of inflammation and Akt signaling pathway-related proteins, which is consistent with the predictions from network pharmacology analysis.
Conclusions
Sirolimus and rosuvastatin inhibited pro-inflammatory cytokine production during the acute stage and regulated Akt/mTOR/NF-κB/STAT3 signaling in the chronic stage of NIH progression. These potential synergistic mechanisms may optimize treatment strategies to improve long-term patency after CABG.