bluuebunny/crossref_metadata_2025_split huggingface dataset:
The Expression and Molecular Mechanisms of Matrix Metalloproteinase- 9 and Vascular Endothelial Growth Factor in Renal Interstitial Fibrosis in Rats
Authors: Lin Shujun , Lin Wenshan , Zhong Zhiqing , Zhong Hongzhen , Zhou Tianbiao , Weng Wenjuan 
Published: November 2023

Objective:
To explore a new approach for the treatment of renal interstitial
fibrosis (RIF), we detected the expression of matrix metalloproteinase-9 (MMP9) and
vascular endothelial growth factor (VEGF).

Methods:
Twenty-four male Sprague Dawley (SD) rats were randomly divided into 2-
week normal control (2NC) group, 4-week NC (4NC) group, 2-week unilateral ureteral
obstruction (2UUO) group, and 4-week UUO (4UUO) group. We performed left ureteral
ligation on UUO groups. Then, we sacrificed the rats of the 2NC group and 2UUO
group at 2 weeks and the other groups at 4 weeks after the surgery.
Immunohistochemistry and western blot were applied to detect the expression of
MMP9, VEGF, fibronectin (FN), type IV collagen (Col-IV), and transforming growth
factor-β1 (TGF-β1). MMP9 levels reduced after UUO surgery. Its expression was less
in the 4UUO group than in the 2UUO group (P<0.05). The expression of VEGF, TGF-
β1, FN, and Col-IV was higher in UUO groups than in NC groups (P<0.05). The
expression of these indicators was higher in the 4UUO group than in the 2UUO group
(P<0.05).

Results:
In the correlation analysis, MMP9 levels in UUO groups had a negative
correlation with the expression of TGF-β1, VEGF, Col-IV, FN, and RIF index (all
P<0.05). In UUO groups, VEGF levels had a positive correlation with the expression of
TGF-β1, Col-IV, FN, and RIF index (all P<0.05).

Conclusion:
In conclusion, with the aggravation of RIF lesions, MMP9 levels
decreased, and VEGF levels increased. Whether there is a mutual inhibition
relationship between them remains to be confirmed by further experiments.
Melatonin Alleviates High Glucose-induced Oxidative Stress and
Mitochondrial Dysfunction in Chondrocytes
Authors: Mehrzadi Saeed , Hassani Shokoufeh , Hosseinzadeh Azam 
Published: November 2023

Background:
Hyperglycemia triggers mitochondrial dysfunction in chondrocytes, potentially
contributing to cell damage and the onset of osteoarthritis.

Objective:
This study is undertaken with the objective of examining the protective properties of melatonin
against toxicity induced by high glucose in C28I2 human chondrocytes.

Methods:
To determine non-cytotoxic concentrations of melatonin, various concentrations (10, 25,
50, 75, 100, 500, and 1000 μM) were assessed over different time periods (24, 48, and 72 hours) for
their impact on C28I2 cell viability. Following this, cells underwent a pretreatment with melatonin
(10 and 100 μM) for 6 hours. This was followed by subjecting the cells to a high concentration of
glucose (75 mM) for 48 hours. Oxidative stress markers, including reactive oxygen species (ROS)
and malondialdehyde (MDA), alongside the enzymatic activities of glutathione peroxidase, superoxide
dismutase, and catalase were quantitatively assessed. To assess mitochondrial function, we evaluated
the adenosine diphosphate (ADP)/adenosine triphosphate (ATP) ratio and measured the mitochondrial
membrane potential (MMP).

Results:
Elevated glucose levels significantly increased ROS and MDA levels, accompanied by reduced
MMP, an elevated ADP/ATP ratio, and altered antioxidant enzyme activity. Pretreatment with
melatonin effectively reversed the mitochondrial toxicity induced by high glucose (75 mM).

Conclusion:
These results indicate that melatonin exhibits a protective influence against hyperglycemia-
induced toxicity in chondrocyte mitochondria.
The Determination of the Factors Affecting Financial Technology Use Behavior of Students
Authors: Ria Reny , Widihastuti Widihastuti 
Published: November 2023

AbstrakPenelitian ini dilakukan untuk menyelidiki dampak simultan dan parsial dari faktor-faktor penentu terhadap perilaku penggunaan teknologi finansial (tekfin). Selanjutnya, desain kuantitatif deskriptif digunakan dengan pendekatan kausal dengan sampel sebanyak 139 siswa SMK Negeri di Kota Madiun. Pengumpulan data juga dilakukan melalui pemberian kuesioner, dan analisis dilakukan dengan menggunakan structural equation modeling (SEM). Hasil penelitian menunjukkan bahwa niat perilaku, kondisi yang memfasilitasi, dan kebiasaan berpengaruh positif dan signifikan terhadap perilaku penggunaan tekfin secara simultan dan parsial. Kata kunci: Kondisi Yang Memfasilitasi, Niat, Penggunaan Tekfin, Perilaku
Wearable Artificial Intelligence for Detecting Anxiety: Systematic Review and Meta-Analysis
Authors: Abd-alrazaq Alaa , AlSaad Rawan , Harfouche Manale , Aziz Sarah , Ahmed Arfan , Damseh Rafat , Sheikh Javaid 
Published: November 2023

Background
Anxiety disorders rank among the most prevalent mental disorders worldwide. Anxiety symptoms are typically evaluated using self-assessment surveys or interview-based assessment methods conducted by clinicians, which can be subjective, time-consuming, and challenging to repeat. Therefore, there is an increasing demand for using technologies capable of providing objective and early detection of anxiety. Wearable artificial intelligence (AI), the combination of AI technology and wearable devices, has been widely used to detect and predict anxiety disorders automatically, objectively, and more efficiently.

Objective
This systematic review and meta-analysis aims to assess the performance of wearable AI in detecting and predicting anxiety.

Methods
Relevant studies were retrieved by searching 8 electronic databases and backward and forward reference list checking. In total, 2 reviewers independently carried out study selection, data extraction, and risk-of-bias assessment. The included studies were assessed for risk of bias using a modified version of the Quality Assessment of Diagnostic Accuracy Studies–Revised. Evidence was synthesized using a narrative (ie, text and tables) and statistical (ie, meta-analysis) approach as appropriate.

Results
Of the 918 records identified, 21 (2.3%) were included in this review. A meta-analysis of results from 81% (17/21) of the studies revealed a pooled mean accuracy of 0.82 (95% CI 0.71-0.89). Meta-analyses of results from 48% (10/21) of the studies showed a pooled mean sensitivity of 0.79 (95% CI 0.57-0.91) and a pooled mean specificity of 0.92 (95% CI 0.68-0.98). Subgroup analyses demonstrated that the performance of wearable AI was not moderated by algorithms, aims of AI, wearable devices used, status of wearable devices, data types, data sources, reference standards, and validation methods.

Conclusions
Although wearable AI has the potential to detect anxiety, it is not yet advanced enough for clinical use. Until further evidence shows an ideal performance of wearable AI, it should be used along with other clinical assessments. Wearable device companies need to develop devices that can promptly detect anxiety and identify specific time points during the day when anxiety levels are high. Further research is needed to differentiate types of anxiety, compare the performance of different wearable devices, and investigate the impact of the combination of wearable device data and neuroimaging data on the performance of wearable AI.

Trial Registration
PROSPERO CRD42023387560; https://www.crd.york.ac.uk/prospero/display_record.php?RecordID=387560
Coupled heterogeneous and homogeneous combustion characteristics of methane-air mixtures in free-piston micro-engines
Authors: Brown Christopher , Chen Junjie 
Published: November 2023

The heterogeneous and homogeneous combustion-based homogeneous charge
compression ignition of fuel-lean methane-air mixtures over
alumina-supported platinum catalysts was investigated experimentally and
numerically in free-piston micro-engines without ignition sources.
Single-shot experiments were carried out in the purely homogeneous and
coupled heterogeneous and homogeneous combustion modes, involved
temperature measurements, capturing the visible combustion image
sequences, exhaust gas analysis, and the physicochemical
characterization of catalysts. Simulations were performed with a
two-dimensional transient model that includes detailed heterogeneous and
homogeneous chemistry and transport, leakage, and free-piston motion to
gain physical insight and to explore the heterogeneous and homogeneous
combustion characteristics. The micro-engine performance concerning
combustion efficiency, mass loss, energy density, and free-piston
dynamics was investigated. The results reveal that heterogeneous
reactions cause earlier ignition, which is very favourable for the
micro-device. Both purely homogeneous and coupled heterogeneous and
homogeneous combustion of methane-air mixtures in a narrow cylinder with
a diameter of 3 mm and a height of approximately 0.3 mm are possible.
Heat losses result in higher mass losses. The coupled heterogeneous and
homogeneous mode can not only significantly improve the combustion
efficiency, in-cylinder temperature and pressure, output power and
energy density, but also reduce the mass loss because of its lower
compression ratio and less time spent around the top dead centre and
during the expansion stroke, indicating that this coupled mode is a
promising combustion scheme for micro-engines.
Keywords: Micro-engines; Homogeneous combustion; Free-piston
dynamics; Power generation; Transient models; Micro-combustion
Efficiency and performance of exothermic combustion and endothermic reforming processes in co-current flow modes
Authors: Brown Christopher , Chen Junjie 
Published: November 2023

The steam reforming of hydrocarbon fuels for the production of synthesis
gas or hydrogen is a well-established technology. A common process is
steam-reforming, where a suitable reforming catalyst facilitates the
reaction between the hydrocarbon feed and steam to generate carbon
monoxide and hydrogen. This study relates to a thermochemical process
for producing hydrogen by the catalytic endothermic reaction of methanol
with steam in a thermally integrated microchannel reforming reactor.
Computational fluid dynamics simulations are conducted to better
understand the consumption, generation, and exchange of thermal energy
between endothermic and exothermic processes in the reactor. The effects
of wall heat conduction properties and channel dimensions on heat
transfer characteristics and reactor performance are investigated.
Thermodynamic analysis is performed based on specific enthalpy to better
understand the evolution of thermal energy in the reactor. Design
recommendations are made to improve thermal performance for the reactor.
The results indicate that the peak reaction heat flux increases with the
channel dimensions while maintaining the flow rates. Reaction heat flux
profiles are considerably affected by channel dimensions. The thermal
conductivity of the channel walls is fundamentally important. Materials
with high thermal conductivity are preferred for the channel walls.
Thermally conductive ceramics and metals are well-suited. Wall materials
with poor heat conduction properties degrade the reactor performance.
The change in specific enthalpy is positive for the exothermic reaction
and negative for the endothermic reaction. The change in specific
sensible enthalpy is always positive.
Keywords: Efficiencies; Performances; Enthalpy; Hydrocarbons;
Conductivities; Hydrogen
The global influence of the IUCN Red List can hinder species conservation efforts
Authors: Palacio Ruben Dario , Abarca María , Armenteras Dolors , Balza Ulises , Dollar Luke J. , Froese Graden Z.L. , Galligan Bryan P. , Giordano Anthony J. , Gula Jonah , Jacobson Andrew P. , Jędrzejewski Włodzimierz , Khorozyan Igor , Mastretta-Yanes Alicia , Moreno Juan Sebastián , Mudumba Tutilo , Nana Eric D. , Naveda-Rodríguez Adrián , Negret Pablo J. , Crespo Guillermo Ortuño , Serrano Filipe C. , Serrano-Villavicencio José E. , Sundar K. S. Gopi , Thomas Evert , Villar D. A. , Hughes Alice C. 
Published: November 2023

The IUCN Red List of Threatened Species is an extinction risk assessment
tool that has guided species conservation over the last five decades.
However, as wildlife scientists and conservationists, we argue that its
influence on the global conservation agenda can hinder effective species
conservation efforts. Here, we review the limitations of the Red List
and its misuse in priority setting, which can overlook local and
regional contexts. This can result in improper allocation of
conservation resources, especially in the Global South, where financial
resources are limited. In particular, funds directed towards red-listed
species may fail to address a broader range of conservation priorities.
We also contend that extinction risk is insufficient for guiding
conservation efforts and recommend broadening conservation planning and
decision-making beyond reliance on the Red List. Thus, for a more
inclusive and decentralized approach, we summarize guidelines for
guiding species conservation at appropriate ecological, spatial, and
taxonomic scales. Finally, we encourage more collaborative efforts and
stakeholder engagement for the setting of conservation priorities and
efficient funding allocation.
Examining Root System Variability in Soybean Using Imaging Technologies
Authors: Bogati Sujata , Carpenter Joshua , Woods Ellen , Jung Jinha , Wang Diane R 
Published: November 2023

ORCiD: [https://orcid.org/0000-0003-0655-2343]
Keywords: Root imaging, root-system architecture (RSA), soybean,
2D-phenotyping & 3D-phenotyping
Roots are a major part of plant systems and are essential to obtaining
water and nutrients. Despite their importance, roots have not been
extensively examined as compared to their aboveground counterparts, due
primarily to the difficulties of access and lack of standard methods to
quantify root morphology. While there have been several experiments
performed under controlled environments, comparatively fewer studies
have examined root architectures under field conditions. Here, we apply
two imaging techniques to characterize variability in Root System
Architecture (RSA) in diverse soybean genotypes under field settings
with two contrasting soil conditions. Thus, our objectives are to (1)
quantify root system architecture using 2D image techniques (e.g.,
Winrhizo and Image J) and (2) evaluate a contrasting subset of these
samples (n = 30) using a novel 3D phenotyping approach. The research
seeks to meet the need for enhanced methods in root system architecture
analysis across diverse field conditions potentially leading to more
resilient, high-yielding soybean varieties.
Zastosowanie leków zobojętniających i antagonistów receptora H2 w postępowaniu z pacjentami z chorobą refluksową przełyku
Authors: Mokrowiecka Anna 
Published: November 2023

Pacjenci z chorobą refluksową mogą prezentować szeroką gamę objawów, powodowanych przez różne mechanizmy patofizjologiczne.
W nich upatruje się możliwych powodów oporności na leczenie i poszukuje się sposobów optymalizacji terapii przez dodanie innych, wskazanych w danych objawach leków. Oprócz szeroko stosowanych inhibitorów pompy protonowej mamy do dyspozycji inne grupy leków, m.in. antagonistów receptora H2 i leki zobojętniające kwas.
viejo y el mar filme animado de Alexandr Petrov
Authors: Vidaurre Arenas Carmen Vitaliana 
Published: November 2023

En este trabajo analizamos el hipertexto fílmico de animación realizado por Alexandr Petrov, derivado de la novela de Ernest Hemingway, a partir de algunas propuestas formuladas por Gérard Genette sobre la transtextualidad, para destacar los principales fenómenos de transformación que se verifican en el filme, respecto a la obra literaria, así como sus consecuencias semánticas.
Entre estas transformaciones se encuentran la reducción del texto literario, pero también la reorganización de ciertos elementos, la exclusión de algunos puntos de anclaje sociocultural que eran señalados en la obra escrita. Estos fenómenos tienen consecuencias semánticas importantes y orientan la interpretación de la trama en un sentido distinto al del texto original.
PENERAPAN METODE QUANTUM TEACHING PADA KEGIATAN ASISTENSI PENGAJARAN AKUNTANSI DI SMA TARSISIUS 1 JAKARTA
Authors: Evelyne Theresya , Imelda Elsa , Sriwati  
Published: November 2023

Creating a pleasant learning atmosphere within the classroom is one of the keys to fostering interest and enthusiasm for learning in students. A fun and interactive learning atmosphere will help students more easily accept the material provided. Teacher-centered is a learning method that is generally carried out in learning activities in schools so that students become quickly bored and passive which results in learning outcomes that are not optimal. So from this problem the answer that may be used is to apply other methods in conducting learning. One method that may be used is the quantum teaching method. The quantum teaching method is a technique that focuses on interaction so as to create a fun and interactive atmosphere, so that students are motivated to learn and have the willingness to be actively concerned within the studying method. This quantum teaching method is applied in the teaching assistance program at SMA Tarsisius 1 Jakarta. The use of quantum teaching methods helps Tarsisius 1 Jakarta High School students to be more active in learning activities. The atmosphere in the study room is quite pleasant, does not seem stiff, and many students are willing to ask questions if they experience difficulties. It might be said that the approach to the quantum teaching method is very helpful in learning activities.
Menciptakan suasana belajar di kelas yang menyenangkan merupakan salah satu kunci dari menumbuhkan minat dan semangat belajar pada siswa. Suasana belajar yang menyenangkan dan interaktif akan membantu pelajar lebih praktis dalam menerima materi yang diberikan. Teacher-centered merupakan suatu metode pembelajaran yang umumnya dilakukan pada kegiatan pembelajaran di sekolah sehingga siswa menjadi cepat jenuh dan pasif yang mengakibatkan hasil belajar yang tidak maksimal. Maka dari permasalahan tersebut jawaban yang bisa digunakan adalah menerapkan metode lain dalam melakukan pembelajaran. Salah satu metode yang dapat diterapkan yaitu metode quantum teaching. Metode quantum teaching adalah sebuah metode yang berfokus pada interaksi yang akan menciptakan suasana kelas yang menyenangkan dan interaktif, sehingga peserta didik termotivasi untuk belajar dan memiliki kemauan untuk terlibat secara aktif pada proses belajar. Metode quantum teaching ini lah yang diterapkan dalam program asistensi mengajar di SMA Tarsisius 1 Jakarta. Penggunaan pendekatan quantum teaching membantu peserta didik SMA Tarsisius 1 Jakarta untuk mampu lebih aktif dalam kegiatan pembelajaran. Suasana belajar dalam kelas pun terbilang cukup menyenangkan, tidak terkesan kaku, dan banyak peserta didik yang mau bertanya jika mengalami kesulitan. Hal tersebut bisa dikatakan bahwa pendekatan dengan quantum teaching method sangat membantu dalam kegiatan pembelajaran.
SOSIALISASI ASPEK HUKUM DAN PERLINDUNGAN HUKUM UMKM DI KABUPATEN INDRAMAYU
Authors: Sudiro Amad , Fernandha Rizqy Dini , Mambo Jr Glen Clifford , Athallah. H.S. Rayhan Mohamad 
Published: November 2023

MSMEs as the backbone of Indonesia's economy are driving the government to actively provide assistance, ranging from administrative, financial or capital equipment to legal aspects. Legal protection for MSMEs comes from existing regulations. Legal protections for MSMEs are clear and create legal certainty. Legal protection for MSMEs can be found in states that grant MSMEs patents on their products. This legal protection cannot be seen only through regulations on unfair competition between companies. MSMEs gain the right to compete in a larger market and to compete with large companies to develop their business. These regulations are expected to protect MSME actors and promote business
UKM sebagai tulang punggung perekonomian Indonesia membuat pemerintah gencar menawarkan bantuan mulai dari pengaturan administrasi, keuangan atau permodalan hingga aspek hukum. Perlindungan hukum UKM dapat dilihat berdasarkan peraturan yang ada. Batas atas hukum untuk UKM jelas dan menawarkan kepastian hukum. Perlindungan hukum terhadap UKM tercermin dalam kenyataan bahwa negara memberikan hak kepada UKM untuk mematenkan produknya, namun tidak hanya perlindungan hukum juga tercermin dalam ketentuan tentang persaingan tidak sehat. UKM diberikan hak untuk bersaing di pasar yang lebih luas dan juga bersaing dengan pengusaha besar untuk mengembangkan usahanya. Peraturan tersebut diharapkan dapat melindungi pelaku UMKM dan mengembangkan usahanya.
PERANCANGAN LOGO REGIONAL WORKSHOP WORLD OCEAN ASSESSMENT BELITUNG
Authors: Valentina Anny , Elysia Celine , Aurellia Meysia Dewi , Natassya Amelia 
Published: November 2023

WOA 2022 is the second international agenda in Belitung Regency after the implementation of the G20 Development Working Group (DWG) in September. The World Ocean Assessment (WOA) is a world maritime meeting that focuses on discussing issues of the marine environment and their social and economic effects. Belitung was chosen because it has sea that still preserved from all kinds activities that can damage the conservation. Considering that the WOA event will be held in December 2022 and is an international event, to welcoming this event the local government needs help from professionals to design a logo event. As a very important visual identity, logo is the main face of a brand and has a meaning that can explain the vision or purpose of the brand. Implementing the method of this PKM, in the first stage communication was carried out with the Belitung Regency Regional Government. Through Deputy Regent Isyak Meirobie, the PKM DKV Untar team was invited to collaborate. The second stage is literature study, observation with visual design that supports the spirit of 'Let's Go Belitung'. Then find a solution to the problem by processing the icons from Belitung into a visualization that is manifested into a logo. In the fifth stage, a visual design is made by applying the Belitung icons to the logo and providing several visual alternatives and making revisions if necessary. In the end, a logo was sent which was then applied to Instagram @kemenkomarves.
WOA 2022 menjadi agenda internasional kedua di Kabupaten Belitung setelah pelaksanaan Development Working Group (DWG) G20 pada bulan September. World Ocean Assessment (WOA) adalah pertemuan maritim dunia yang berfokus membahas isu-isu lingkungan laut dan efeknya terhadap sosial dan ekonomi. Belitung dipilih karena memiliki laut yang masih terjaga kelestarian dari segala macam kegiatan lain yang dapat merusak pelestarian. Mengingat acara WOA akan dilaksanakan pada bulan Desember 2022 dan merupakan acara internasional, maka Pemda membutuhkan bantuan tenaga professional untuk merancang logo event untuk menyambut berlangsungnya event ini di Belitung. Sebagai identitas visual yang sangat penting, logo merupakan wajah utama dari sebuah brand dan tentunya memiliki makna yang dapat menjelaskan visi atau tujuan dari brand tersebut. Metode pelaksanaan PKM, pada tahap pertama dilakukan komunikasi dengan pihak Pemda Kabupaten Belitung. Melaui Wakil Bupati Isyak Meirobie diajaklah tim PKM DKV Untar untuk berkolaborasi. Tahap kedua studi pustaka, observasi dengan perancangan visual yang mendukung agar sesuai dengan spirit ‘Let’s Go Belitung”. Lalu mencari solusi dari permasalahan dengan mengolah ikon-ikon dari Belitung menjadi visualisasi yang diwujudkan menjadi logo. Pada tahap ke lima dibuat rancangan visual dengan mengaplikasikan ikon-ikon Belitung kedalam logo dan memberikan beberapa alternatif visual serta membuat revisi jika diperlukan. Pada akhir dikirimkan logo yang kemudia telah diaplikasikan pada Instagram @kemenkomarves.