bluuebunny/crossref_metadata_2025_split huggingface dataset:
Angulated Edge Intrinsic Defect in Carbon as Bridge‐Adsorption Site of CO for Highly Efficient CO2 Electroreduction
Authors: Zeng Zhouliangzi , Liu Zhixiao , Cao Linlin , Dai Minyang , Zhang Wei , Zhang Yan , Ni Wenpeng , Zhang Shiguo 
Published: February 2024

AbstractPervasive intrinsic defects have a significant impact on the electrocatalytic activity of carbon materials, but previous research has focused on the effects of topological structures exclusively. Herein, a compelling demonstration of the pivotal role played by the positions and spatial arrangement of intrinsic defects in determining their efficacy for electrochemical CO2 reduction (ECR) is presented. Theoretical calculations reveal a substantial reduction in energy barriers for *COOH formation at intrinsic defects positioned along the edges while hindering the transformation of *COOH to *CO in the ECR process. To address this issue, a sea urchin‐like nanocarbon (F1100) is designed, which provides adjacent intrinsic defects located in V‐type arranged carbon nanorods. The angulated edge intrinsic defects facilitate the bridge adsorption of carbon monoxide (CO), as confirmed by in situ attenuated total reflection surface‐enhanced infrared absorption spectroscopy, thereby enhancing the specific activity of ECR on intrinsic carbon defects. In a 0.1 m potassium bicarbonate (KHCO3) solution, F1100 achieves a FECO of 95.0%, while in an ionic liquids‐based electrolyte, a current density of 90.0 mA cm−2 is obtained with nearly complete conversion of CO2 to CO in an H‐type cell.
Dissolvable Immunomodulatory Microneedles for Treatment of Skin Wounds
Authors: Ghelich Pejman , Samandari Mohamadmahdi , Hassani Najafabadi Alireza , Tanguay Adam , Quint Jacob , Menon Nikhil , Ghanbariamin Delaram , Saeedinejad Farnoosh , Alipanah Fatemeh , Chidambaram Ramaswamy , Krawetz Roman , Nuutila Kristo , Toro Steven , Barnum Lindsay , Jay Gregory D. , Schmidt Tannin A. , Tamayol Ali 
Published: February 2024

AbstractSustained inflammation can halt or delay wound healing, and macrophages play a central role in wound healing. Inflammatory macrophages are responsible for the removal of pathogens, debris, and neutrophils, while anti‐inflammatory macrophages stimulate various regenerative processes. Recombinant human Proteoglycan 4 (rhPRG4) is shown to modulate macrophage polarization and to prevent fibrosis and scarring in ear wound healing. Here, dissolvable microneedle arrays (MNAs) carrying rhPRG4 are engineered for the treatment of skin wounds. The in vitro experiments suggest that rhPRG4 modulates the inflammatory function of bone marrow‐derived macrophages. Degradable and detachable microneedles are developed from gelatin methacryloyl (GelMA) attach to a dissolvable gelatin backing. The developed MNAs are able to deliver a high dose of rhPRG4 through the dissolution of the gelatin backing post‐injury, while the GelMA microneedles sustain rhPRG4 bioavailability over the course of treatment. In vivo results in a murine model of full‐thickness wounds with impaired healing confirm a decrease in inflammatory biomarkers such as TNF‐α and IL‐6, and an increase in angiogenesis and collagen deposition. Collectively, these results demonstrate rhPRG4‐incorporating MNA is a promising platform in skin wound healing applications.
In Situ Piezoelectric‐Catalytic Anti‐Inflammation Promotes the Rehabilitation of Acute Spinal Cord Injury in Synergy
Authors: You Yanling , Jiang Junjie , Zheng Gang , Chen Zhixin , Zhu Ya‐Xuan , Ma Hongshi , Lin Han , Guo Xiang , Shi Jianlin 
Published: February 2024

AbstractRelieving inflammation via scavenging toxic reactive oxygen species (ROS) during the acute phase of spinal cord injury (SCI) proves to be an effective strategy to mitigate secondary spinal cord injury and improve recovery of motor function. However, commonly used corticosteroid anti‐inflammatory drugs show adverse side effects which may induce increased risk of wound infection. Fortunately, hydrogen (H2), featuring selective antioxidant performance, easy penetrability, and excellent biosafety, is being extensively investigated as a potential anti‐inflammatory therapeutic gas for the treatment of SCI. In this work, by a facile in situ growth approach of gold nanoparticles (AuNPs) on the piezoelectric BaTiO3, a particulate nanocomposite with Schottky heterojunction (Au@BT) is synthesized, which can generate H2 continuously by catalyzing H+ reduction through piezoelectric catalysis. Further, theoretical calculations are employed to reveal the piezoelectric catalytic mechanism of Au@BT. Transcriptomics analysis and nontargeted large‐scale metabolomic analysis reveal the deeper mechanism of the neuroprotective effect of H2 therapy. The as‐prepared Au@BT nanoparticle is first explored as a flexible hydrogen gas generator for efficient SCI therapy. This study highlights a promising prospect of nanocatalytic medicine for disease treatments by catalyzing H2 generation; thus, offering a significant alternative to conventional approaches against refractory spinal cord injury.
A Nanoscale Trans‐Platinum(II)‐Based Supramolecular Coordination Self‐Assembly with a Distinct Anticancer Mechanism
Authors: He Xidong , Yu Jie , Yin Renyong , Zhang Peng , Xiao Chunsheng , Chen Xuesi 
Published: February 2024

AbstractDrug resistance significantly hampers the clinical application of existing platinum‐based anticancer drugs. New platinum medications that possess distinct mechanisms of action are highly desired for the treatment of Pt‐resistant cancers. Herein, a nanoscale trans‐platinum(II)‐based supramolecular coordination self‐assembly (Pt–TCPP–BA) is prepared via using trans‐[PtCl2(pyridine)(NH3)] (transpyroplatin), tetracarboxylporphyrin (TCPP), and benzoic acid (BA) as building blocks to combat drug resistance in platinum‐based chemotherapy. Mechanistic studies indicate that Pt–TCPP–BA shows a hydrogen‐peroxide‐responsive dissociation behavior along with the generation of bioactive trans‐Pt(II) and TCPP–Pt species. Different from cisplatin, these degradation products interact with DNA via interstrand cross‐links and small groove binding, and induce significant upregulation of cell‐death‐related proteins such as p53, cleaved caspase 3, p21, and phosphorylated H2A histone family member X in cisplatin‐resistant cancer cells. As a result, Pt–TCPP–BA exhibits potent killing effects against Pt‐resistant tumors both in vitro and in vivo. Overall, this work not only provides a new platinum drug for combating drug‐resistant cancer but also offers a new paradigm for the development of platinum‐based supramolecular anticancer drugs.
Ester‐Functionalized Polythiophene Interlayers for Enhanced Performance and Stability of Perovskite Solar Cells
Authors: Rai Nitish , Reddy Saripally Sudhaker , Scully Andrew D. , Weerarathna K. Lakshani Jayaprada , Bach Udo , Simonov Alexandr N. 
Published: February 2024

AbstractInterfacial defects between the organic–inorganic lead halide perovskite and hole‐transporting layers are one significant factor limiting the performance of the perovskite solar cells (PSCs). These defects typically result from either lead or halide atom vacancies or under‐coordinated Pb2+ atoms, which act as recombination centers for holes. To address this, it is demonstrated that a thin layer of a poly(bithiophene ester) (PBTE) or a poly(terthiophene diester) (PTTDE) introduced between the FA0.92MA0.08Pb(I0.92Br0.08)3 (MA+ = methylammonium; FA+ = formamidinium) perovskite and spiro‐OMeTAD hole transporting material (HTM) layers improves the device stability and power‐conversion efficiency (PCE). The PCE improvements are primarily associated with enhanced open‐circuit voltage and fill factor arising from Lewis‐base passivation of under‐coordinated Pb2+ through interaction with the polymer carbonyl groups, as well as enhanced charge transfer between the perovskite and HTM layers facilitated by the conjugated thiophene functionalities of the polymeric interlayer. Furthermore, the examined polymers improve the thermal and moisture stability of the devices. Encapsulated PSCs with PBTE and PTTDE retain 89 ± 1 and 94 ± 3% of their initial PCE after 1440 h at 65 °C under 0.5‐sun irradiation, respectively, while PSCs without a polymeric interlayer lose almost half of the performance. These results can guide future designs of polymeric interlayers for high‐performance PSCs.
WS2/Mesoporous Carbon Nanostructures as a Bifunctional Electrode for All Quasi‐Solid‐State Supercapacitor and Oxygen Evolution Reaction
Authors: Iqbal Muzahir , Saykar Nilesh G. , Singh Abhijeet , Ahmed Imtiaz , Arya Anil , Haldar Krishna Kanta , Mahapatra S. K. 
Published: February 2024

Abstract2D transition‐metal sulfides have developed as favorable electroactive materials for electrochemical energy storage and conversion applications. In this work, WS2/mesoporous carbon (MC) is developed by a one‐step hydrothermal technique for supercapacitor and oxygen evaluation reaction (OER) application. However, the metal sulfides have poor rate and cyclic performance due to the aggregations between two layers of structures restricting their performance. The interaction between WS2 nanosheets and MC produces a synergistic effect, resulting in a decent electrochemical energy storage and conversion application. The synthesized materials used to prepare quasi‐solid‐state symmetric (QSSS) and asymmetric (QSSA) supercapacitor configuration enable the highest specific capacitance (CSP) of 305.45 F g−1 and 204.21 F g−1@ 10 mV s−1, respectively. Moreover, the specific energy and power density of QSSS and QSSA devices are 31.1 Wh kg−1 @824.95 W kg−1 and 24.74 Wh kg−1 @549.84 W kg−1, respectively. Additionally, the multifunctionality of the synthesized binary nanocomposite is also tested for OER. The composite shows a desirable over potential of 307 mV in 6 m KOH electrolyte, with a 69 mV dec−1 Tafel slope. The dual role of WS2/MC for energy storage and oxygen evaluation reaction conversion reveals the potential of metal sulfides.
Harnessing Protein Waste into Reduced Graphitic Carbon Oxide‐Copper‐Collagen Nanocomposite for Visible Light Photocatalytic Degradation of Nano Plastics
Authors: Subbiah Nagaraj , Palanisamy Thanikaivelan 
Published: February 2024

AbstractNano and micro plastics are harmful to the aqueous environment and the current treatment systems are either ineffective or expensive, which restricts their widespread use. In this research, reduced graphitic carbon oxide (rGO)‐Cu nanoparticles crosslinked with collagen support (rGO‐Cu/Coll) are employed as an efficient photocatalyst for the degradation of polystyrene (PS) nano plastics in water. It is shown that rGO‐Cu/Coll nanocomposite can degrade PS nano plastics when subjected to simulated visible light and direct sunlight. In the photocatalytic degradation of PS nano plastics, the reactive radical species (•OH and O2•−) produced on the surfaces of rGO‐Cu/Coll nanocomposite materials play major roles in de‐polymerization. The investigation of the FESEM, Raman, and UV–vis spectra of the irradiated and non‐irradiated samples reveal observable changes, including the distorted morphology and formation of a new band, with longer exposure times and greater degradation. Additionally, evidence for the photodegradation of PS chains is demonstrated by the observed increase in the intensities of the carboxylate, carbonyl, and hydroxyl absorption regions of the ATR‐FTIR spectra. The study provides a simple approach to the battle against plastic pollution in aquatic ecosystems using green photocatalysts under visible light including direct sunlight without consuming additional energy.
Quadruple Control Electrochromic Devices Utilizing Ce4W9O33 Electrodes for Visible and Near‐Infrared Transmission Intelligent Modulation
Authors: Ma Dongyun , Yang Ting , Feng Xingzhe , Wang Pengfei , Huang Jiahui , Wang Jinmin , Li Haizeng 
Published: February 2024

AbstractElectrochromic smart windows are promising for building energy savings due to their dynamic regulation of the solar spectrum. Restricted by materials or traditional complementary device configuration, precisely and independently controlling of visible (VIS) and near‐infrared (NIR) light is still on the drawing board. Herein, a novel Zn2+ electrochemically active Ce4W9O33 electrode is reported, which demonstrates three distinct states, including VIS and NIR transparent “bright and warm” state, VIS and NIR opaque “dark and cool” state, VIS transparent and NIR opaque “bright and cool” state. A dual‐operation mode electrochromic platform is also presented by integrating Ce4W9O33/NiO complementary device and Zn anode‐based electrochromic device (Ce4W9O33/Zn/NiO device). Such a platform enables an added VIS opaque and NIR transparent “dark and warm” state, thus realizing four color states through individually controlling Ce4W9O33 and NiO electrodes, respectively. These results present an effective approach for facilitating electrochromic windows more intelligent to weather/season conditions and personal preferences.
Impact of dupilumab prescribing on utilization of medical and surgical therapies for chronic rhinosinusitis with nasal polyps
Authors: Low Christopher M. , Wang Allan R. , Yong Michael , Nayak Jayakar , Patel Zara , Hwang Peter H. 
Published: February 2024

Key points
Increased dupilumab utilization coincided with decreased ESS in patients with CRSwNP between 2019 and 2021.
One potential confounder was the concurrent COVID‐19 pandemic, which may have negatively impacted surgery utilization rates.
Amphiphilic Covalent Organic Framework Nanoparticles for Pickering Emulsion Catalysis with Size Selectivity
Authors: Zou Houbing , Li Qibiao , Zhang Rongyan , Xiong Zeshan , Li Binghua , Wang Junhao , Wang Runwei , Fang Qianrong , Yang Hengquan 
Published: February 2024

AbstractExploiting advanced amphiphilic solid catalysts is crucial to the development of Pickering emulsion catalysis. Herein, covalent organic framework (COF) nanoparticles constructed with highly hydrophobic monomers as linkers were found to show superior amphiphilicity and they were then developed as a new class of solid emulsifiers for Pickering emulsion catalysis. Employing amphiphilic COFs as solid emulsifiers, Pickering emulsions with controllable emulsion type and droplet sizes were obtained. COF materials have also been demonstrated to serve as porous surface coatings to replace traditional surface modifications for stabilizing Pickering emulsions. After implanting Pd nanoparticles into amphiphilic COFs, the obtained catalyst displayed a 3.9 times higher catalytic efficiency than traditional amphiphilic solid catalysts with surface modifications in the biphasic oxidation reaction of alcohols. Such an enhanced activity was resulted from the high surface area and regular porous structure of COFs. More importantly, because of their tunable pore diameters, Pickering emulsion catalysis with remarkable size selectivity was achieved. This work is the first example that COFs were applied in Pickering emulsion catalysis, providing a platform for exploring new frontiers of Pickering emulsion catalysis.
Transformation of the pheromone 3‐methyl‐2‐cyclohexen‐1‐ol in the presence of [RuClCp (PTA)2] and [RuCp (OH2)(PTA)2]CF3SO3
Authors: López‐Sánchez Belén , Scalambra Franco , Romerosa Antonio 
Published: February 2024

The catalytic conversion of the substituted cyclic allylic alcohol 3‐methyl‐2‐cyclohexen‐1‐ol was studied in the presence of the metal complexes [RuClCp (PTA)2] (1) and [RuCp (OH2)(PTA)2]CF3SO3 (2) (PTA = 1,3,5‐triaza‐7‐phosphaadamantane) in different media such as water, methanol, and biphasic water/cyclohexane. Slight changes of the reaction conditions led to the isomerization to 3‐methylcyclohexanone, oxidation to 3‐methyl‐2‐cyclohexenone, or 1,3‐transposition to 1‐methyl‐2‐cyclohexen‐1‐ol. The 1,3‐transposition and oxidation reactions took place in water, and the selective formation of the isomerization product was achieved in freshly dried methanol, or biphasic water/cyclohexane mixture, achieving the highest TON values known to date. Furthermore, the reactivity of 3‐methyl‐2‐cyclohexen‐1‐ol in water was also investigated in the absence of a catalyst, revealing the formation of the 1,3‐transpostion product 1‐methyl‐2‐cyclohexen‐1‐ol and the etherification product 1‐methyl‐3‐(3‐methyl‐2‐cyclohexen‐1‐yl)oxycyclohexene. Finally, key mechanistic aspects of the different reaction pathways were enlightened by NMR spectroscopy.
Salt resistant and self‐cleaning CNTs‐SEBS‐MAH composite membrane for seawater desalination
Authors: Cui Baozheng , Chen Xuelong , Chen Lina , Zhu Jingbo , Zhang Caiyan , Bai Ningjing , Wang Wei , Wang Huixin , Zhao Dongyu , Li Zewen , Niu Haijun , Wang Zhe 
Published: February 2024

AbstractSolar‐driven steam generation membranes have garnered increasing attention for freshwater production. Nonetheless, the adverse impact of salt accumulation on membrane surfaces directly undermines the efficacy of solar evaporation. In this work, one type of composite membrane comprised of carbon nanotubes (CNTs)‐styrene‐ethylene‐butadiene‐styrene (SEBS) was fabricated by modified vapor phase pore‐forming technique. Through the grafting of maleic anhydride (MAH), the CNTs‐SEBS‐MAH composite membrane was successfully hydrolyzed. As a consequence, the composite membrane exhibits evaporation rate as high as 1.28 kg m−2 h−1 under one sun solar irradiation, accompanied by an outstanding solar vapor conversion efficiency of 87.5%. In addition, the fabricated composite membrane has high resistance to salt accumulation, as well as self‐cleaning capability. This work provides a route for manufacturing hydrophilic polymer composite membrane towards solar energy driven seawater desalination.
Schiff‐base Polymer Immobilized Ruthenium for Efficient Catalytic Cross‐coupling of Secondary Alcohols with 2‐amino‐ and γ‐aminobenzyl Alcohols to Give Quinolines and Pyridines
Authors: Li Lei , Zhao Yuting , Zang Jiyuan , Yu Lei , Young David J. , Ren Zhi‐Gang , Li Hong‐Xi 
Published: February 2024

AbstractA Schiff–base porous polymer has been impregnated with ruthenium trichloride for acceptor–free dehydrogenation coupling (ADC) of secondary alcohols with γ‐amino‐ and 2‐aminobenzyl alcohols to give pyridines and quinolines. This heterogenous catalyst exhibited high catalytic efficiency over repeated cycles with wide functional group tolerance.
Docetaxel, cisplatin, and fluorouracil with pegfilgrastim on day 3 as neoadjuvant chemotherapy for esophageal cancer
Authors: Maeda Osamu , Furune Satoshi , Kanda Mitsuro , Miyata Kazushi , Shimizu Dai , Sugita Shizuki , Nishida Kazuki , Ando Masahiko , Kodera Yasuhiro , Ando Yuichi 
Published: February 2024

AbstractPurposeA high risk of febrile neutropenia (FN) from neoadjuvant chemotherapy with docetaxel, cisplatin, and fluorouracil (DCF) for esophageal cancer has been reported. The optimal timing of prophylactic use of pegfilgrastim remains to be elucidated. To evaluate the effect of pegfilgrastim administered on day 3, we conducted a feasibility study.MethodsChemotherapy consisted of intravenous administration of docetaxel (70 mg/m2 per day) and cisplatin (70 mg/m2 per day) on day 1 and continuous infusion of 5‐fluorouracil (750 mg/m2 per day) on days 1–5. Pegfilgrastim was given as a single subcutaneous injection at a dose of 3.6 mg on day 3 during each treatment course. This regimen was repeated every 3 weeks for up to a maximum of three courses. Prophylactic antibiotics were not needed but were allowed to be given at the discretion of the physician. The primary endpoint was the incidence of FN.ResultsTwenty‐six patients were administered DCF in combination with pegfilgrastim on day 3. After the first course of DCF, 10 out of 26 patients (38.5%) experienced grade 4 neutropenia, and two patients (7.7%) experienced FN. Of the 14 patients who did not receive prophylactic antibiotics, four had grade 4 neutropenia, including two who developed FN. On the contrary, of the 12 patients who received prophylactic levofloxacin, six had grade 4 neutropenia, but no cases of FN were observed.ConclusionAdministration of pegfilgrastim on day 3 was not sufficient to prevent FN due to DCF treatment, and prophylactic administration of both pegfilgrastim and antibiotics could be a solution.
Effect of DNA Origami Nanostructures on Bacterial Growth
Authors: Garcia‐Diosa Jaime Andres , Grundmeier Guido , Keller Adrian 
Published: February 2024

AbstractDNA origami nanostructures are a powerful tool in biomedicine and can be used to combat drug‐resistant bacterial infections. However, the effect of unmodified DNA origami nanostructures on bacteria is yet to be elucidated. With the aim to obtain a better understanding of this phenomenon, the effect of three DNA origami shapes, i.e., DNA origami triangles, six‐helix bundles (6HBs), and 24‐helix bundles (24HBs), on the growth of Gram‐negative Escherichia coli and Gram‐positive Bacillus subtilis is investigated. The results reveal that while triangles and 24HBs can be used as a source of nutrients by E. coli and thereby promote population growth, their effect is much smaller than that of genomic single‐ and double‐stranded DNA. However, no effect on E. coli population growth is observed for the 6HBs. On the other hand, B. subtilis does not show any significant changes in population growth when cultured with the different DNA origami shapes or genomic DNA. The detailed effect of DNA origami nanostructures on bacterial growth thus depends on the competence signals and uptake mechanism of each bacterial species, as well as the DNA origami shape. This should be considered in the development of antimicrobial DNA origami nanostructures.
Amorphous Anode Materials for Fast‐charging Lithium‐ion Batteries
Authors: Vishwanathan Savithri , Pandey Harshit , Ramakrishna Matte H. S. S. 
Published: February 2024

AbstractFast‐charging technology is set to revolutionize the field of lithium‐ion batteries (LIBs), driving the creation of next‐generation devices with the ability to get charged within a short span of time. From the anode perspective, it is of paramount importance to design materials that can withstand continuous Li+ insertion/deinsertion at high charging rates and still remain unaffected by factors such as mechanical fractures, electrolyte side reactions, polarisation, lithium plating and heat generation. Herein, the recent advancements in the design of amorphous materials as anodes for fast‐charging LIBs have been discussed. While the development of this particular class of materials for application in high‐rate anodes has been paid limited attention in recent literature, it holds immense promise for improving the fast‐charging capabilities. This concept summarizes the recent strides made in this emerging field, outlining the strategies employed in the design of amorphous anodes and emphasizing the crucial role played by the amorphous nature in achieving fast‐charging performance. Further, the successive initiatives that can be undertaken to drive the progress of amorphous materials for fast charging LIBs have also been detailed, which could potentially improve their commercial viability.