bluuebunny/crossref_metadata_2025_split huggingface dataset:
The effects of suppressing inflammation by tofacitinib may simultaneously improve glycaemic parameters and inflammatory markers in rheumatoid arthritis patients with comorbid type 2 diabetes: a proof-of-concept, open, prospective, clinical study
Authors: Di Muzio Claudia , Di Cola Ilenia , Shariat Panahi Azadeh , Ursini Francesco , Iagnocco Annamaria , Giacomelli Roberto , Cipriani Paola , Ruscitti Piero 
Published: January 2024

Abstract
Background
A consistent connection has been increasingly reported between rheumatoid arthritis (RA), insulin resistance (IR), and type 2 diabetes (T2D). The β-cell apoptosis induced by pro-inflammatory cytokines, which could be exaggerated in the context of RA, is associated with increased expression pro-apoptotic proteins, which is dependent on JAnus Kinase/Signal Transducer and Activator of Transcription (JAK/STAT) activation. On these bases, we aimed to evaluate if the administration of tofacitinib, a potent and selective JAK inhibitor, could simultaneously improve glycaemic parameters and inflammatory markers in patients with RA and comorbid T2D.

Methods
The primary endpoint was the change in the 1998-updated homeostatic model assessment of IR (HOMA2-IR) after 6 months of treatment with tofacitinib in RA patients with T2D. Consecutive RA patients with T2D diagnosis were included in this proof-of-concept, open, prospective, clinical study, which was planned before the recent emergence of safety signals about tofacitinib. Additional endpoints were also assessed regarding RA disease activity and metabolic parameters.

Results
Forty consecutive RA patients with T2D were included (female sex 68.9%, mean age of 63.4 ± 9.9 years). During 6-month follow-up, a progressive reduction of HOMA2-IR was observed in RA patients with T2D treated with tofacitinib. Specifically, a significant effect of tofacitinib was shown on the overall reduction of HOMA2-IR (β =  − 1.1, p = 0.019, 95%CI − 1.5 to − 0.76). Also, HOMA2-β enhanced in these patients highlighting an improvement of insulin sensitivity. Furthermore, although a longer follow-up is required, a trend in glycated haemoglobin reduction was also recorded. The administration of tofacitinib induced an improvement in RA disease activity, and a significant reduction of DAS28-CRP and SDAI was observed; 76.8% of patients achieved a good clinical response. In this study, no major adverse events (AEs) were retrieved without the identification of new safety signals. Specifically, no life-threatening AEs and cardiovascular and/or thromboembolic events were recorded.

Conclusions
The administration of tofacitinib in RA with T2D led to a simultaneous improvement of IR and inflammatory disease activity, inducing a “bidirectional” benefit in these patients. However, further specific designed and powered studies are warranted to entirely evaluate the metabolic effects of tofacitinib in RA patients with T2D.
Manifestation and sociodemographic microdata of Brazil’s Unified Health System Ombudsman
Authors: de Freitas Saldanha Raphael , Kreischer Vinicius , Gritz Raquel , Miloski Matheus , Bonifácio Carmen Lúcia Corrêa , Cardoso Carlos Leonardo Souza , Alves Ariane Camilo Pinheiro , de Sá Domício Aurélio , Gurgel Junior Garibaldi Dantas , Moreira Rafael da Silveira , Fernandez Michelle Vieira , Lima Jefferson da Costa , Pedroso Marcel 
Published: January 2024

Abstract
Objectives
This article presents the process of extraction and treatment of two datasets from the General Ombudsman of the Brazilian Unified Health System (OUVSUS). The resulting datasets allow the analysis of manifestation characteristics and sociodemographic profile of the citizens that performed these manifestations.

Data description
The first dataset depicts the characteristics of the manifestations registered by the General Ombudsman. Each row represents an individual manifestation and contains information such as the registration date, classification, input channel, and subject, among others. The second dataset is constituted of sociodemographic information for each citizen that performed a manifestation, and characteristics such as sexual orientation, race, age, and geographic location of the citizen are presented, among others.
Consensus on relevant psychosocial interventions applied in health institutions to prevent psychological violence at work: Delphi method
Authors: Abregú-Tueros Luis Fidel , Bravo-Esquivel Cinthia Jannete , Abregú-Arroyo Sheyla Karol , Dos Santos-Rosa Roger , Galve-Manzano José Luis 
Published: January 2024

Abstract
Objective
Studies on psychological violence in the workplace (PVW) in Latin America have focused on incidence values. In contrast, studies on preventive interventions (PIs) in the health sector are very limited. Our objective was to determine to what extent there is consensus on the most relevant characteristics of the psychosocial interventions applied in the prevention of PVW in health institutions in Peru. To that end, health professionals with knowledge and experience in PVW at the national level were recruited, and the Delphi consensus technique was applied.

Results
The consensus study was developed in four stages that included three phases of Delphi consultation. In the third consultation phase, 428 experts participated in 25 analysis groups from 66 health institutions in the country. A total of 70.3% of the participants were women, and 27.6% of the participants worked in nursing and emergency services. After the Delphi consensus analysis, we obtained a list of 10 hierarchical psychosocial interventions to prevent PVW in the country. Most notable were interventions based on the prior resolution of interprofessional conflicts, on the visibility of incidents to generate an inverse effect and on experiential training to improve assertive and empathic communication skills.
A new pachypleurosaur (Reptilia: Sauropterygia) from the Middle Triassic of southwestern China and its phylogenetic and biogeographic implications
Authors: Hu Yi-Wei , Li Qiang , Liu Jun 
Published: January 2024

AbstractAfter the devastating Permo-Triassic Mass Extinction, several new groups of large reptilian predators invaded the sea in the early part of the Triassic. Among these predators, sauropterygians, consisting of placodonts, pachypleurosaurs, nothosaurs and pistosaurs (including the iconic plesiosaurs), displayed the greatest diversity at both the generic and species levels, and persisted from the Early Triassic to the Late Cretaceous. Here, we report a new species of Pachypleurosauria, Dianmeisaurus mutaensis sp. nov., from a recently discovered Lagerstätte in the Upper Member of the Anisian Guanling Formation. The only known specimen of the new species was collected from a quarry near Muta village, Luxi County, Yunnan Province, South China. Our new phylogenetic analysis based on a novel data matrix recovered the new taxon as a sister group to Dianmeisaurus gracilis—a small pachypleurosaur from the Middle Triassic Luoping biota. The new phylogenetic analysis also collapsed the monophyly of the traditionally recognized Eusauropterygia. Pistosauroidea, Majiashanosaurus, and Hanosaurus comprise the consecutive sister groups to a new clade including Pachypleurosauria and Nothosauroidea. A monophyletic Pachypleurosauria, within which the clade consisting of Dianmeisaurus and Panzhousaurus occupies the basal-most position, is recovered by this study. The clade consisting of Dawazisaurus and Dianopachysaurus forms the sister group to the remaining pachypleurosaurs included in this study. Since Dianmeisaurus, Panzhousaurus, Dawazisaurus, and Dianopachysaurus are all exclusively known from South China, our study provides further evidence to the hypothesis that pachypleurosaurs had a palaeobiogeographic origin in the eastern Tethys.ZooBank LSID: urn:lsid:zoobank.org:pub:83D12411-9189-4313-A8F0-27AF61BDA51E.
Effects of isoflurane anaesthesia depth and duration on renal function measured with [99mTc]Tc-mercaptoacetyltriglycine SPECT in mice
Authors: Schmitz-Peiffer Fabian , Lukas Mathias , Mohan Ajay-Mohan , Albrecht Jakob , Aschenbach Jörg R. , Brenner Winfried , Beindorff Nicola 
Published: January 2024

Abstract
Background
The influence of anaesthetic depth and the potential influence of different anaesthetic beds and thus different handling procedures were investigated in 86 severe combined immunodeficient (SCID) mice using semi-stationary dynamic single photon emission computed tomography (SPECT) for kidney scintigraphy. Therefore, isoflurane concentrations were adjusted using respiratory rate for low (80–90 breath/min) and deep anaesthesia (40–45 breath/min). At low anaesthesia, we additionally tested the influence of single bed versus 3-mouse bed hotel; the hotel mice were anaesthetized consecutively at ~ 30, 20, and 10 min before tracer injections for positions 1, 2, and 3, respectively. Intravenous [99mTc]Tc-MAG3 injection of ~ 28 MBq was performed after SPECT start. Time-activity curves were used to calculate time-to-peak (Tmax), T50 (50% clearance) and T25 (75% clearance).

Results
Low and deep anaesthesia corresponded to median isoflurane concentrations of 1.3% and 1.5%, respectively, with no significant differences in heart rate (p = 0.74). Low anaesthesia resulted in shorter aortic blood clearance half-life (p = 0.091) and increased relative renal tracer influx rate (p = 0.018). A tendency toward earlier Tmax occurred under low anaesthesia (p = 0.063) with no differences in T50 (p = 0.40) and T25 (p = 0.24). Variance increased with deep anaesthesia. Compared to single mouse scans, hotel mice in position 1 showed a delayed Tmax, T50, and T25 (p < 0.05 each). Furthermore, hotel mice in position 1 showed delayed Tmax versus position 3, and delayed T50 and T25 versus position 2 and 3 (p < 0.05 each). No difference occurred between single bed and positions 2 (p = 1.0) and 3 (p = 1.0).

Conclusions
Deep anaesthesia and prolonged low anaesthesia should be avoided during renal scintigraphy because they result in prolonged blood clearance half-life, delayed renal influx and/or later Tmax. Vice versa, low anaesthesia with high respiratory rates of 80–90 rpm and short duration (≤ 20 min) should be preferred to obtain representative data with low variance.
Factors influencing HPV vaccine implementation in South Asia: a scoping review protocol
Authors: Rajkhowa Priyobrat , Pundir Prachi , Dsouza Sherize Merlin , Patil Divya Sussana , Narayanan Prakash , Brand Helmut 
Published: January 2024

Abstract
Introduction
The HPV vaccine is characterized by its significant effectiveness in preventing the occurrence of cervical cancer. However, the South Asian countries face multiple challenges in implementing the human papillomavirus vaccine (HPV) at scale. Implementation of human papillomavirus vaccination for eliminating cervical cancer necessitates investigating the factors that impact the health system of these nations. Hence, this review will map the evidence on factors influencing the scaling up of human papillomavirus vaccination in South Asia.

Methods
The proposed scoping review will follow the steps given by Arksey and O’Malley and Levac et al. The search approach will follow McGowan et al. (14) evidence-based manual for Peer Analysis of Electronic Search Strategies (PRESS 2015) for systematic searches. Using a comprehensive search, the literature from 2006 onward will be identified from PubMed, CINAHL, EMBASE, Web of Science, and Scopus. The search strategy will include terms relating to the HPV vaccine and implementation. A predefined criterion for the inclusion and exclusion of studies will be adopted by three review authors independently to determine the eligible studies. The results will be narratively synthesized and examined in addition to being quantitatively presented to provide an outline. The review will be presented per the “Preferred Reporting Items for Systematic Reviews and Meta-analyses extension for scoping review (PRISMA-ScR)” guidelines.

Conclusions/discussion
The evaluation is anticipated to map the barriers and enablers influencing the rollout of the human papillomavirus vaccine. Lessons learned from the South Asian countries, where the vaccine has been implemented, may contribute to aiding the implementation of the vaccine in countries with similar health systems in an effective manner.

Systematic review registration
The protocol was prospectively registered on the “open science framework”. The registration DOI is https://doi.org/10.17605/OSF.IO/T5SW9.
The effects of apoptosis inhibitor of macrophage in kidney diseases
Authors: Cao Yixia , Hu Boyan , Fan Yunhe , Wang Wei , Chi Mingxuan , Nasser Moussa Ide , Ma Kuai , Liu Chi 
Published: January 2024

AbstractKidney disease is a progressive and irreversible condition in which immunity is a contributing factor that endangers human health. It is widely acknowledged that macrophages play a significant role in developing and causing numerous kidney diseases. The increasing focus on the mechanism by which macrophages express apoptosis inhibitor of macrophages (AIM) in renal diseases has been observed. AIM is an apoptosis inhibitor that stops different things that cause apoptosis from working. This keeps AIM-bound cell types alive. Notably, the maintenance of immune cell viability regulates immunity. As our investigation progressed, we concluded that AIM has two sides when it comes to renal diseases. AIM can modulate renal phagocytosis, expedite the elimination of renal tubular cell fragments, and mitigate tissue injury. AIM can additionally exacerbate the development of renal fibrosis and kidney disease by prolonging inflammation. IgA nephropathy (IgAN) may also worsen faster if more protein is in the urine. This is because IgA and immunoglobulin M are found together and expressed. In the review, we provide a comprehensive overview of prior research and concentrate on the impacts of AIM on diverse subcategories of nephropathies. We discovered that AIM is closely associated with renal diseases by playing a positive or negative role in the onset, progression, or cure of kidney disease. AIM is thus a potentially effective therapeutic target for kidney diseases.
Uncertainty about interest rates and crude oil prices
Authors: Qadan Mahmoud , Cohen Gil 
Published: January 2024

AbstractThe yield on the 10-year U.S. Treasury Note is among the most cited interest rates by investors, policymakers, and financial institutions. We show that the 10-year Treasury yield’s forward-looking volatility, a VIX-style measure that is a proxy for uncertainty about future interest rates, is a useful state variable capable of predicting the returns and volatility of crude oil prices over the near term. Using monthly data from 2003 to 2020, we document that higher implied volatility in the 10-year U.S. Treasury derivatives market predicts declining oil prices and higher forward-looking volatility in those prices. Our results are robust to different subsamples and various empirical designs.
The Tardive Dyskinesia Impact Scale (TDIS), a novel patient-reported outcome measure in tardive dyskinesia: development and psychometric validation
Authors: Farber Robert H. , Stull Donald E. , Witherspoon Brooke , Evans Christopher J. , Yonan Charles , Bron Morgan , Dhanda Rahul , Jen Eric , Brien Christopher O.’ 
Published: January 2024

Abstract
Background
Tardive dyskinesia (TD), a movement disorder in which patients experience abnormal involuntary movements, can have profound negative impacts on physical, cognitive, and psychosocial functioning. The Abnormal Involuntary Movement Scale (AIMS), a clinician-rated outcome, is considered the gold standard for evaluating treatment efficacy in TD clinical trials. However, it provides little information about the impacts of uncontrolled movements from a patient perspective and can be cumbersome to administer in clinical settings. The Tardive Dyskinesia Impact Scale (TDIS) was developed as a patient-reported outcome measure to fulfill the need for a disease-specific impact assessment in TD. The objective of the present study was to develop and evaluate the psychometric properties of the TDIS to determine whether it is fit-for-purpose to measure TD impact.

Methods
Data from qualitative studies and phase 3 trials of a VMAT2 inhibitor for the treatment of TD (KINECT3 and KINECT4) were used to determine the psychometric properties of the TDIS. Qualitative research included concept elicitation and cognitive debriefing interviews with TD patients and their caregivers in order to assess how well the TDIS captured key domains of TD impact. Quantitative analyses to examine the psychometric properties of the TDIS included assessing construct validity (factor structure, known groups, and predictive validity) and responsiveness to change.

Results
Qualitative results showed that the TDIS captures the key TD impacts reported by patients and caregivers and that the TDIS was interpreted as intended and relevant to patients’ experiences. Quantitative results found evidence of 2 underlying domains of the TDIS: physical and socioemotional (Comparative Fit Index > 0.9). Known groups and predictive validity indicated that, compared with the AIMS, the TDIS captures unique content (correlation between AIMS and TDIS = 0.2–0.28). The TDIS showed responsiveness to change in treatment, with TDIS scores improving over 48 weeks in the 2 phase 3 trials.

Conclusions
The TDIS captures relevant information about the impact of TD and is easily administered in a clinician’s office or patient’s home. It may be used longitudinally to show changes in TD burden over time. The TDIS complements the AIMS; using these assessments together provides a more holistic assessment of TD.
Influence of fall armyworm Spodoptera frugiperda egg mass scales and layers on the performance of three species of egg parasitoid Trichogramma with different ovipositor lengths
Authors: Navik Omprakash , Dsilva Lerissa Sweety , Patil Jagadeesh , Sushil S. N. 
Published: January 2024

Abstract
Background
The fall armyworm (FAW), Spodoptera frugiperda (J.E. Smith) (Lepidoptera: Noctuidae) is a highly polyphagous and destructive pest of maize and other cereal crops. Biological control is a potential alternative to chemical insecticides used for the management of FAW in maize. Egg parasitoids are promising biocontrol agents as they kill the insect pest at their egg stage before it hatches, thus preventing the damaging larval stage. Trichogramma is widely used in augmentative biological control of FAW in native and invaded regions. However, FAW lay egg masses in layer by layer and eggs are covered with egg scales, this may affect the performance of Trichogramma parasitoids. Therefore, the parasitism potential of three Trichogramma species was studied on eggs with or without scales and layered eggs of FAW, further the impact of parasitoids ovipositor length on parasitism was also determined. This helps to understand the parasitism potential of parasitoids on different egg type for better implementation of biological control programs against FAW.

Results
The effect of FAW egg mass with or without scales and layered eggs on the performance of Trichogramma chilonis, T. pretiosum and T. mwanzai was studied and results indicated that egg mass scales and the layered eggs were significantly affected the parasitism potential of Trichogramma species, but did not affect the parasitoid emergence. In general, T. chilonis parasitized a higher percentage of eggs with or without scales and layered eggs of FAW than the other two species. T. chilonis and T. mwanzai had a greater ovipositor length than T. pretiosum.

Conclusion
The performance of evaluated Trichogramma species on FAW eggs with or without scales and layered eggs affected the parasitism success. The parasitism success of T. chilonis was comparably higher than other tested species. Hence, the scales on egg masses and layered eggs of FAW should be taken into account while selecting the Trichogramma species in the biological control of FAW.
Nutritional composition and mineral profile of leaves of Moringa oleifera provenances grown in Gaborone, Botswana
Authors: Masitlha Eng P. , Seifu Eyassu , Teketay Demel 
Published: January 2024

AbstractAlthough Moringa is an important vegetable crop elsewhere, its nutritional and non-food uses are not widely known in Botswana community. This study was conducted to determine the chemical composition and mineral contents of leaves of Moringa oleifera trees grown in Gaborone, Botswana. The leaf samples were collected from Moringa trees grown in the backyards of six different households in Gaborone city. They were dried separately at 55 ºC for 24 h and then ground to obtain a powder for analysis. The data on the proximate composition of the Moringa samples were subjected to Analysis of Variance to determine statistical differences among the mean values. The overall mean values of moisture, fat, protein, ash, fiber and total available carbohydrates of the leaves were 6.93 ± 0.16, 7.78 ± 0.13, 27.1 ± 0.43, 7.34 ± 0.31, 9.1 ± 1 and 46.5 ± 3%, respectively. The Moringa leaves contained average values of 520 ± 96.0, 7.7 ± 1.3, 30.1 ± 15.5, 0.8 ± 0.1, 82.6 ± 6.4, 1.7 ± 0.2, 1.6 ± 0.2 and 0.02 ± 0.00 mg/100g of Calcium, Iron, Sodium, Zinc, Magnesium, Aluminum, Manganese and Chromium, respectively. Significant differences were observed for moisture, fat, protein and ash contents among the six Moringa samples. The results showed that the leaves are rich in nutrients, particularly with high amounts of protein and ash. This suggests that Moringa leaf could serve as an important protein and mineral supplement in the diet and can be consumed as a vegetable in Botswana. The difference in composition observed between the Moringa leaf samples suggests a possible genotypic difference between the Moringa trees used in this experiment. Thus, there is a need for further study to verify this.
Graphical Abstract