bluuebunny/crossref_metadata_2025_split huggingface dataset:
Abdominal cocoon syndrome (ACS): a case report of a Chinese male diagnosed idiopathic ACS with inborn short intestine
Authors: Li Fei , Xie Miao 
Published: December 2023

Introduction and importance:
Abdominal cocoon syndrome (ACS), as a rare cause of mechanical intestinal obstruction, can be divided into primary/idiopathic vs. secondary type. The primary ACS is often asymptomatic and only diagnosed in exploratory laparotomy. The major treatment of surgery can be challenging. Since the gut wall and peritoneum are densely adhered, gut perforation might occur during adhesiolysis. Thus, it is important to have an experienced surgeon to perform the surgery.

Case presentation:
The authors present a primary ACS case of a 50-year-old man. The patient demonstrated an unbearable upper abdominal pain upon admission. A computed tomography (CT) scan showed a severe bowel obstruction. An exploratory laparotomy was indicated, leading to the diagnosis of ACS, which was considered idiopathic after ruling out secondary factors. An adhesiolysis was performed successfully. Note that the entire intestine measured was only 2.1 m during the surgery. There was no post-surgical complication. The patient was recovered uneventfully.

Clinical discussion:
The aetiology of primary ACS is unknown. The incidence is comparatively low and considered equal between men and women. As a rare cause of gut obstruction, the suspicion of the diagnosis should be strengthened. Surgery including adhesiolysis and bowel resection remains the major treatment. If adhesiolysis fails, bowel resection will be inevitable. The knowledge and experience of surgeon will be tested.

Conclusion:
The aetiology of primary ACS should be further explored. And the differential diagnosis of bowel obstruction should cover ACS in order for the surgeon to be prepared before surgery.
COVID-19 and chronic kidney disease: a bibliometric analysis
Authors: Jiang Wenze , Chen Yuting , Zhao Yuxin , Gao Yang , Cheng Tianyang , Qian Enhui , Hou Yating , Lu Keda 
Published: December 2023

Background:
The COVID-19 pandemic has caused over 656 million confirmed cases and over 6.6 million deaths worldwide. Chronic kidney disease (CKD) is considered a high-risk factor for COVID-19; therefore, considerable research has been conducted in this field. Therefore, this study aims to conduct a bibliometric analysis of publications related to COVID-19 and CKD.

Methods:
Publications were retrieved from the Web of Science Core Collection database on 16 January 2023 and screened based on inclusion criteria. Then the authors used Microsoft Excel and CiteSpace to analyze the included publications from the following seven aspects: countries/regions, institutions, journals, authors, cited references, and keywords.

Results:
In total, 622 publications were included in the study. The USA has the most publications in this field, followed by China. The Icahn School of Medicine at Mount Sinai and Harvard Medical School had the highest number of publications in the field. Journal of Clinical Medicine had the largest number of publications, and Lancet was the most cited journal. Alberto Ortiz was the author with the largest number of publications, but there were no influential authors in this field. The highly cited references are mainly clinical studies on COVID-19. Research hotspots in this field include end-stage recent disease, cardiovascular disease, kidney metastasis, diabetes Mellitus, acute kidney injury, meta-analysis, and consistent plasma.

Conclusions:
The USA, China, and some European countries and their institutions are major contributors to these publications. End-stage renal disease, acute kidney injury, kidney transplantation and convalescent plasma are current hot topics in the field.
Obstetric Racism, Education, and Racial Concordance
Authors: Major-Kincade Terri L. 
Published: December 2023

Abstract
The United States holds the distinction of being the developed country with the worst perinatal outcomes despite spending the most per capita on health care. Black women are three to four times more likely than White women to experience adverse birth outcomes. These outcomes persist despite access to prenatal care, insurance, and college education. A long overdue racial reckoning has arrived, beginning with acknowledging the fallacy of race-based medicine and the role of enduring systemic racism as foundational to obstetric racism in the reproductive lives of Black women. Centering voices of Black women and honoring their lived experiences are essential to providing respectful maternity care. Naming micro- and macroaggressions experienced by Black women allows for dismantling of systemic barriers which perpetuate inequitable outcomes and enable substandard care. Racial concordance (shared racial identity) is one tool to consider in creating safe health care spaces for Black women. Improving diversity of the nursing workforce specifically and the health care workforce in general is necessary to affect racial concordance. Application of skills in cultural humility can mitigate challenges associated with adverse patient encounters for Black women as diversity pipeline strategies are explored. Histories of foundational fallacy, their impact on care and outcomes, and patient-driven indicators for improving pregnancy care experiences for women of color are explored through the lens of a Black physician and the collective reproductive health workforce.
Postpartum Mental Health and Perceptions of Discrimination Among Asian Fathers During the COVID-19 Pandemic
Authors: Goyal Deepika , Dol Justine , Huynh Jackie , Anand Sulekha , Dennis Cindy-Lee 
Published: December 2023

Abstract

Purpose:
The purpose of this study was twofold: (1) to examine the prevalence of postpartum depression and anxiety symptomatology among fathers of Asian descent living in North America during the COVID-19 pandemic, and (2) to identify the occurrences of online racial discrimination.

Study Design and Methods:
Using a cross-sectional design and convenience sampling methods, we recruited fathers online via social media sites (Facebook, Instagram) between March 12 and July 31, 2022. The Edinburgh Postnatal Depression Scale, General Anxiety Scale, and the Online Victimization Scale assessed mental health well-being and discrimination outcomes. Data were analyzed using descriptive statistics, two sample t-test, chi-square test of independence, and Pearson's correlation analysis.

Results:
Our sample included 61 fathers within 6 months postpartum living in the United States and Canada. Participants were on average 34 years old, married, and represented 17 Asian ethnic groups, including Asian Indian (41%), Filipino (11.3%), and Korean (8.1%). One-third of our participants (31.1%, n = 19) were at high risk of developing postpartum depression and scores of three (4.9%) fathers indicated they had clinically significant anxiety. Overall, 26.3% reported experiencing direct online racial discrimination and 65% reported occurrences of indirect online racial discrimination.

Clinical Implications:
There was a high rate of depressive symptoms and occurrences of online racial discrimination among fathers of Asian descent living in North America. These rates are higher than the general perinatal population and further research is warranted to examine risk factors and preventive strategies among this unique paternal ethnic group.
68Ga-Oxine–Labeled Erythrocytes as a New PET Tracer for the Localization of Gastrointestinal Bleeding
Authors: Leder Theresa , Kühnel Christian , Gröber Sebastian , Drescher Robert , Freesmeyer Martin 
Published: December 2023

Abstract
A 69-year-old man presented with recurring drops in hemoglobin levels and suspected gastrointestinal bleeding. Endoscopy did not show a site of bleeding so further examinations became necessary. Scintigraphy and SPECT/CT with 99mTcO4
−–labeled red blood cells were performed without evidence of a hemorrhage. Based on an established protocol for splenic PET/CT, autologous erythrocytes can be labeled with 68Ga-oxine and used as a tracer for the localization of active bleeding sites. In the patient, PET/CT with 68Ga-oxine–labeled undamaged erythrocytes was performed successfully and revealed a hemorrhage of the gastric corpus that was confirmed and treated by endoscopy.
ChIP-DIP: A multiplexed method for mapping hundreds of proteins to DNA uncovers diverse regulatory elements controlling gene expression
Authors: Perez Andrew A. , Goronzy Isabel N. , Blanco Mario R. , Guo Jimmy K. , Guttman Mitchell 
Published: December 2023

AbstractGene expression is controlled by the dynamic localization of thousands of distinct regulatory proteins to precise regions of DNA. Understanding this cell-type specific process has been a goal of molecular biology for decades yet remains challenging because most current DNA-protein mapping methods study one protein at a time. To overcome this, we developed ChIP-DIP (ChIP Done In Parallel), a split-pool based method that enables simultaneous, genome-wide mapping of hundreds of diverse regulatory proteins in a single experiment. We demonstrate that ChIP-DIP generates highly accurate maps for all classes of DNA-associated proteins, including histone modifications, chromatin regulators, transcription factors, and RNA Polymerases. Using these data, we explore quantitative combinations of protein localization on genomic DNA to define distinct classes of regulatory elements and their functional activity. Our data demonstrate that ChIP-DIP enables the generation of ‘consortium level’, context-specific protein localization maps within any molecular biology lab.
The α/β hydrolase domain-containing protein 1 (ABHD1) acts as a lysolipid lipase and is involved in lipid droplet formation
Authors: Torres-Romero Ismael , Légeret Bertrand , Huleux Marie , Sorigue Damien , Damm Alicia , Cuiné Stéphan , Veillet Florian , Blot Carla , Brugière Sabine , Couté Yohann , Garneau Matthew G. , Kotapati Hari Kiran , Xin Yi , Xu Jian , Bates Philip D. , Thiam Abdou Rachid , Beisson Fred , Li-Beisson Yonghua 
Published: December 2023

AbstractLipid droplets (LDs) are the major sites of lipid and energy homeostasis. However, few LD biogenesis proteins have been identified. Here, usingChlamydomonasas a model, we show that ABHD1, a member of the α/β hydrolase domain-containing protein family, is a novel type of LD-associated protein which stimulates LD formation through two distinct actions on the LD surface, one enzymatic and the other structural. ABHD1 was localized to LD surface inChlamydomonascells. The knockout mutants contained similar amounts of triacylglycerols (TAG) but their LDs showed an increased content in lyso- derivatives of the betaine lipid diacylglyceryl-N,N,N-trimethylhomoserine (DGTS). Over-expression ofABHD1in Chlamydomonas induced LD formation and boosted TAG content, suggesting a key role in LD biogenesis. The purified recombinant ABHD1 protein hydrolyzed lyso-DGTS, producing a free fatty acid and a glyceryltrimethylhomoserine moiety. In vitro experiments using droplet- embedded vesicles showed that ABHD1 promoted LD emergence. Taken together, these results identify ABHD1 as a new player in LD formation by its lipase activity on lyso-DGTS and by its distinct biophysical property. This study further suggests that lipases targeted to LDs and able to act on their polar lipid coat may be interesting tools to promote LD assembly in eukaryotic cells.Significant statementLipid droplets are subcellular organelles specialized for triacylglycerol storage. Their dynamic turnover is key to managing energy homeostasis in response to cell cycle states and environmental cues. To gain insights into LD biogenesis, we characterized a putative α/β- hydrolase (ABHD1) in the model algaeChlamydomonas reinhardtiiand show it is located at the LD surface. We found that ABHD1 overexpression promotes LD formation and acts as a lipase mainly on lyso derivatives of the betaine lipid diacylglyceryl-N,N,N-trimethylhomoserine (DGTS), the major lipid constituent of the LD hemi-membrane. We also show that ABHD1 has a remarkable biophysical property favoring LD budding. This work thus identifies a novel type of lipase acting on betaine lipid and provides a first example of a protein with a dual function nvolved in LD formation.
Melon: metagenomic long-read-based taxonomic identification and quantification using marker genes
Authors: Xi Chen , Yin Xiaole , Shi Xianghui , Yan Weifu , Yang Yu , Liu Lei , Zhang Tong 
Published: December 2023

AbstractLong-read sequencing holds great potential for characterizing complex microbial communities, yet taxonomic profiling tools designed specifically for long reads remain lacking. Here we introduce Melon, a novel marker-based taxonomic profiler that capitalizes on the unique attributes of long reads. Melon employs a two-stage classification scheme to reduce computational time and is equipped with an expectation-maximization-based post-correction module to handle ambiguous reads. Melon achieves superior performance compared to other existing tools in both mock and simulated samples. Using wastewater metagenomic samples, we demonstrate the applicability of Melon by showing it is capable in providing reliable estimates of overall genome copies, and species-level taxonomic profiles.
Sequential genetic and epigenetic alterations in human pluripotent stem cells for recurrent abnormality
Authors: Kim Yun-Jeong , Kang Byunghee , Kweon Solbi , Oh Sejin , Kim Dayeon , Gil Dayeon , Lee Hyeonji , Kim Jung-Hyun , Ju Ji Hyeon , Roh Tae-Young , Hong Chang Pyo , Cha Hyuk-Jin 
Published: December 2023

AbstractHuman embryonic stem cells (hESCs) are naturally equipped to maintain genome integrity to minimize genetic mutations during early embryo development. However, genetic aberration risks and subsequent cellular changes in hESCs duringin vitroculture pose a significant threat to stem cell therapy. While a few studies have reported specific somatic mutations and copy number variations (CNVs), the molecular mechanisms underlying ‘culture-adapted phenotype’ acquisitions of hESCs are largely unknown. Therefore, we conducted comprehensive genomic, single-cell transcriptomic, and single-cell ATAC-seq analyses of an isogenic hESC model displaying definitive ‘culture-adapted phenotypes.’ Notably, hPSCs with a copy number gain of 20q11.21 during early passage did not present ‘culture-adapted phenotypes’ norBCL2L1induction. Single-cell RNAseq and ATACseq analyses revealed active transcriptional regulation at 20q11.21 loci at late-passaged hESCs with the inducedBCL2L1andTPX2to trigger ‘culture-adapted phenotypes’ was associated with epigenetic changes facilitating TEA domain (TEAD) binding. These results suggest that copy number 20q11.21 gain and additional epigenetic changes are necessary for expressing ‘culture-adapted phenotypes’ by activating gene transcription at this specific locus.
The activated plant NRC4 immune receptor forms a hexameric resistosome
Authors: Liu Furong , Yang Zhenlin , Wang Chao , Martin Raoul , Qiao Wenjie , Carette Jan E. , Luan Sheng , Nogales Eva , Staskawicz Brian 
Published: December 2023

AbstractInnate immune responses against microbial pathogens in both plants and animals are regulated by intracellular receptors known as Nucleotide-binding Leucine-rich Repeats (NLR) proteins. In plants, these NLRs play a crucial role in recognizing pathogen effectors, thereby initiating the activation of immune defense mechanisms. Notably, certain NLRs serve as “helper” NLR immune receptors (hNLR), working in tandem with “sensor” NLR immune receptors (sNLR) counterparts to orchestrate downstream signaling events to express disease resistance. In this study, we reconstituted and determined the cryo-EM structure of the hNLR required for cell death 4 (NRC4) resistosome. The auto-active NRC4 formed a previously unanticipated hexameric configuration, triggering immune responses associated with Ca2+influx into the cytosol. Furthermore, we uncovered a dodecameric state of NRC4, where the coil-coil (CC) domain is embedded within the complex, suggesting an inactive state, and expanding our understanding of the regulation of plant immune responses.One Sentence SummaryThe hexameric NRC4 resistosome mediates cell death associated with cytosolic Ca2+influx.
Emergence of AI enabled smart buildings in India: a road towards sustainable performance
Authors: Gupta Akshit , Tandon Urvashi 
Published: December 2023

Purpose
The concept of sustainable performance is gaining attention from researchers all over the world for the betterment of society as a whole. Pollution and climate change has instigated an awareness to switch to sustainable built environment. The present research aims to analyze the indicators of adoption of smart buildings and their impact on dimensions of sustainability, namely, economic, social and environmental performance.

Design/methodology/approach
Data was collected from 332 respondents staying in smart buildings. Structural equation modeling was applied to analyze the data.

Findings
The results of the study indicated adoption of smart buildings depicted a stronger perceived sustainable environmental and economic performance while social performance emerged as a weak outcome variable as compared to the other two performances.

Originality/value
The study thus has tremendous implications for construction companies so that they may design smart buildings by adequately using artificial intelligence. To the best of the authors’ knowledge, this research is one of the initial studies to understand the perception of residents of smart buildings using smart technology in India.
Trigger points and high growth firms: the vital role of founder “sensing” and “seizing” capabilities
Authors: Rees-Jones Rachael E. , Brown Ross , Jones-Evans Dylan 
Published: December 2023

PurposeResearch on high growth firms is booming yet a strong conceptual understanding of how these firms obtain (and sustain) rapid growth remains (at best) partial. The main purpose of this paper is to explore the role founders play in enabling episodes of rapid growth and how they help navigate this process.Design/methodology/approachThis paper reports the findings from a qualitative study involving in-depth interviews with entrepreneurs enlisted onto a publicly funded high growth business accelerator programme in Wales. These interviews explored the causes of the firms rapid growth, their key growth trigger points and the organisational consequences of rapid growth.FindingsThe research reveals that periods of high growth are intrinsically and inextricably inter-linked with the entrepreneurial traits and capabilities of their founders coupled with their ability to “sense” and “seize” pivotal growth opportunities. It also demonstrates founder-level dynamic capabilities enable firms to capitalise on pivotal “trigger points” thereby enabling their progression to a new “dynamic state” in a firm’s temporal evolution.Originality/valueThe novel approach towards theory building deployed herein is the use of theoretical elaboration as means of extending important existing theoretical constructs such as growth “trigger points” and founder dynamic capabilities. To capitalise on these trigger points, founders have to undergo a process of “temporal transitioning” to effectively manage and execute the growth process in firms. The work also has important policy implications, underlining the need for more relational forms of support for entrepreneurial founders.
Marketing intelligence and small firms' performance: the role of entrepreneurial alertness and effectuation
Authors: Karami Masoud , Hossain Mokter 
Published: December 2023

Purpose Knowledge of how entrepreneurial alertness (EA) and effectuation impact small firms' performance in uncertain markets is limited. Suggesting effectuation as a mediation mechanism between EA and small firms' performance, the authors explore how entrepreneurs of small firms apply effectual logic to translate their individual alertness to market opportunities into firms' performance.Design/methodology/approachA set of hypotheses is tested by partial least squares analysis of survey data collected from small firms in New Zealand.FindingsThe results show that effectuation works as a mechanism that mediates a positive association between founders'/managers' alertness to market opportunities and small firms' performance.Originality/valueIntegrating EA with the effectuation theory, the authors contribute to the literature on new market opportunity development and firm performance. The authors argue that entrepreneurs concentrate on action and resources to further develop their marketing intelligence in developing new market opportunities. The authors also enhance the understanding of entrepreneurial marketing decision-making by small firms in a relatively small economy in the Asia–Pacific region.
Autonomous vehicles adoption motivations and tourist pro-environmental behavior: the mediating role of tourists’ green self-image
Authors: Mehmood Shafaqat , Khan Salman 
Published: December 2023

Purpose
This study aims to examine the impact of autonomous vehicles adoption motivations (i.e. technological, ecological and intrinsic motivation) on tourists’ pro-environmental behavior and verify the mediating role of tourists’ green self-image between the relationship of eco-friendly attitudes and autonomous vehicles adoption motivations.

Design/methodology/approach
The data from 586 national and international tourists were analyzed using the partial least squares method.

Findings
The findings revealed that eco-friendly attitude is a significant predictor of tourists’ green self-image; tourists’ green self-image is a significant predictor of autonomous vehicles adoption motivations; and autonomous vehicles adoption motivations are significant predictors of tourists’ pro-environmental behavior. In addition, tourists’ green self-image mediated the relationship between eco-friendly attitudes and autonomous vehicles adoption motivations.

Originality/value
These outcomes provide valuable guidance for the future development of green destination tourism and allow interesting implications for the tourism industry and autonomous vehicles adoption.