bluuebunny/crossref_metadata_2025_split huggingface dataset:
Effect of load details of the successive explosions on the blast behaviors of reinforced concrete beams
Authors: Xu Yingliang , Liu Yan , Huang Fenglei , Yan Junbo , Bai Fan , Li Xu , Wang Hongfu 
Published: October 2023

SummaryThe objective of this study was to study the effect of load details of successive explosions on the blast behaviors of reinforced concrete (RC) beams. First, the effect of the successive loading of two identical explosions was discussed by considering the influences of standoff distance, charge mass on the failure states, and structural responses (displacement and support reaction force). And keeping the total TNT charge mass of 1 kg unchanged, the effect of loading numbers was investigated by loading two 0.5 kg TNT successively and a single 1 kg TNT on RC beams, respectively. Besides, the successive loading of two different explosions was also considered by investigating the effects of loading sequences and the first explosion induced pre‐damage on the ultimate accumulated damage of RC beams. At last, based on the reaction force and displacement responses, a nonlinear relationship between the dynamic residual load‐carrying capacity and the accumulated residual displacement was obtained to assess the damage states of the tested beams. The results show that the local failure range along the beam span direction (length of peeling‐off and length of spallation) caused by the first blast load did not apparently increase when the damaged beams were subjected to another blast load. With the increase in explosion numbers, depth of compressive crushing increases gradually. At the same stand‐off distance (from 0.25 to 0.45 m), due to the damage accumulation effect, successive loading of two 0.5 kg TNT can trigger more severe local failure but smaller accumulated residual deflection to beams than the single loading of a 1 kg TNT. Besides, when two different blast loads are loaded on tested beams, the loading sequence of the larger one first and then the smaller one (1 kg TNT/0.5 kg TNT at h = 0.45 m) can trigger larger damage to beams than the opposite loading sequence (0.5 kg TNT/1 kg TNT at h = 0.45 m). And for the beams subjected to a smaller blast load first and then a larger one, a stiffer behavior may be triggered by the second blast load on the beam after the first loading of the smaller blast load due to the residual strain in longitudinal reinforcement. Furthermore, based on the nonlinear relationship between residual load‐carrying capacity and residual displacement, the accumulated damage of RC beams was divided into mainly four phases.
Blocking exosomal secretion aggravated 1,4‐benzoquinone‐induced cytotoxicity
Authors: Zhang Qianqian , Lu Fangfang , Zhang Chunxiao , Yu Xiuyuan , Yang Xinjun , Yan Hongtao 
Published: October 2023

AbstractBenzene exposure inhibits the hematopoietic system and leads to the occurrence of various types of leukemia. However, the mechanism underlying the hematotoxicity of benzene is still largely unclear. Emerging evidence has shown that exosomes are involved in toxic mechanisms of benzene. To understand the effect of 1,4‐benzoquinone (PBQ; an active metabolite of benzene in bone marrow) on the exosomal release characteristics and role of exosomal secretion in PBQ‐induced cytotoxicity. Exosomes were isolated from PBQ‐treated HL‐60 cells, purified by ultracentrifugation, and verified by transmission electron microscopy, nanoparticle tracking analysis and the presence of specific biomarkers. Our results showed that PBQ increased exosomal secretion in a dose‐dependent manner, reaching a peak in 3 h at 10 μM PBQ treatment and then slowly decreasing in HL‐60 cells. The exosomes contained miRNAs, which have been reported to be associated with benzene exposure or benzene poisoning. In particular, mir‐34a‐3p and mir‐34A‐5p were enriched in exosomes derived from PBQ‐treated cells. In addition, the inhibition of exosomal release by GW4869 (an inhibitor of exosomal release) exacerbated PBQ‐induced cytotoxicity, including increased intracellular reactive oxygen species levels, decreased mitochondrial membrane potential, and increased the apoptosis rate. Our findings illustrated that exosomes secretion plays an important role in antagonizing PBQ‐induced cytotoxicity and maintaining cell homeostasis.
A randomized, double‐blind, placebo‐controlled, parallel‐group 12‐week pilot phase II trial of SaiLuoTong (SLT) for cognitive function in older adults with mild cognitive impairment
Authors: Steiner‐Lim Genevieve Z. , Bensoussan Alan , Andrews‐Marney Elana R. , Al‐Dabbas Mahmoud A. , Cave Adele E. , Chiu Christine L. , Christofides Katerina , De Blasio Frances M. , Dewsbury Lauren S. , Fagan Naomi L. , Fogarty Jack S. , Hattom Lena C. , Hohenberg Mark I. , Jafar Deyyan , Karamacoska Diana , Lim Chai K. , Liu Jianxun , Metri Najwa‐Joelle , Oxenham D. Vincent , Ratajec Holly , Roy Nikita , Shipton Danielle G. , Varjabedian David , Chang Dennis H. 
Published: October 2023

AbstractINTRODUCTIONThis study primarily aimed to evaluate the efficacy and safety of SaiLuoTong (SLT) on cognition in mild cognitive impairment (MCI).METHODSCommunity‐dwelling people with MCI aged ≥60 years were randomly assigned to 180 mg/day SLT or placebo for 12 weeks.RESULTSThirty‐nine participants were randomized to each group (N = 78); 65 were included in the final analysis. After 12 weeks, the between‐groups difference in Logical Memory delayed recall scores was 1.40 (95% confidence interval [CI]: 0.22 to 2.58; P = 0.010); Delis–Kaplan Executive Function System Trail Making Test Condition 4 switching and contrast scaled scores were 1.42 (95% CI: –0.15 to 2.99; P = 0.038) and 1.56 (95% CI: –0.09 to 3.20; P = 0.032), respectively; Rey Auditory Verbal Learning Test delayed recall was 1.37 (95% CI: –0.10 to 2.84; P = 0.034); and Functional Activities Questionnaire was 1.21 (95% CI: –0.21 to 2.63; P = 0.047; P < 0.001 after controlling for baseline scores).DISCUSSIONSLT is well tolerated and may be useful in supporting aspects of memory retrieval and executive function in people with MCI.Highlights
SaiLuoTong (SLT) improves delayed memory retrieval and executive function in people with mild cognitive impairment (MCI).
SLT is well tolerated in people ≥ 60 years.
The sample of community dwellers with MCI was well characterized and homogeneous.
Effect of nutraceutical supplementation on semen quality in stallions
Authors: Díaz Rojas Edgar , Carrillo Moreno Dalia I. , Contreras Villarreal Viridiana , Arellano Rodríguez Fernando , Alvarado Espino Alan S. , Ángel García Oscar 
Published: October 2023

AbstractBackgroundThe use of reproductive biotechnologies in equine practice has shown that some stallions are subfertile, so ways to improve fertility have been sought.ObjectiveThis study aimed to evaluate the effect of nutraceutical supplementation on improving semen quality in Quarter Horse stallions.MethodsSemen from six Quarter Horse stallions was assessed for 4 months every 20 days using the computer‐assisted semen analysis system. They were evaluated for 60 days before supplementation; then, the same stallions were re‐evaluated for 60 days with nutraceutical supplementation (30 g/day).ResultsVolume showed no significant difference (p > 0.05) with nutraceuticals. Sperm concentration (10x6) was significantly higher with supplementation (339.4 ± 17.5 sperm/mL) than without supplementation (224.6 ± 19.9). Sperm abnormalities (%) were significantly (p < 0.05) lower with supplementation (14.3 ± 0.6) than without supplementation (19.1 ± 0.4). Sperm kinematic parameters, total motility (TM), progressive motility (PM), rectilinear velocity (VSL), the velocity of the trajectory (VAP) and curvilinear velocity (VCL), were significantly better with supplementation (p < 0.05).ConclusionsBased on the results, it is concluded that nutraceutical supplementation improved semen parameters in Quarter Horse stallions.
Evaluation of automated staple sizes on gastric layer incorporation and intraluminal pressure for partial gastrectomy closure in an ex vivo canine model
Authors: Blumenthal Michael , Bertran Judith , Regier Penny , Cole James , Maxwell Elizabeth A 
Published: October 2023

AbstractObjectiveTo evaluate the performance of automated staple sizes on a cadaveric canine partial gastrectomy model.MethodsStomachs were transected through the gastric body axis and randomly allocated to two closure groups: Group B, thoracoabdominal (TA) stapler 3.5 mm staple cartridge (blue); Group G, TA stapler 4.8 mm staple cartridge (green). After construct completion, leak testing was performed for both groups and compared. Initial leakage pressure (ILP), maximal leakage pressure (MLP) and leakage location were recorded. Staple lines were evaluated by direct observation and fluoroscopy to assess sub‐mucosal layer incorporation and staple conformation. Staple shape was classified as optimal or suboptimal. Significance was set at p less than 0.5.ResultsFollowing gastrectomy, the mean double gastric wall thickness was 7.82 ± 2.05 mm at the gastric body. Mean ILP was significantly lower in groups G (17.13 ± 1.19 mmHg) compared to group B (50.46 ± 6.03 mmHg, p = 0.0013). Similarly, mean MLP was significantly lower in group G (21.41 ± 1.39 mmHg) compared to group B (64.61 ± 10.21 mmHg, p < 0.0001). Although group G had higher percentage of B‐shaped staple formation compared to group B, this was not significant (group G; 92.38%, group B; 54.56%; p = 0.054).ConclusionThe 3.5 mm TA staple cartridge (blue) achieved superior bursting pressures compared with the 4.8 mm TA staple cartridge (blue) for the closure of a canine partial gastrectomy model. Both staple sizes incorporated all gastric layers. No differences were noticed in optimal staple conformation between groups. In vivo investigation is warranted to evaluate the use of different staple sizes on gastric tissue perfusion, successful healing and post‐operative stasis and dehiscence.
Remarkable tailoring of thermal and dielectric properties of poly(vinyl alcohol) nanocomposite via hydrothermal grown ZnAl layer di hydroxide nanostructures and graphene fillers
Authors: Ritu  , Patel Manoj Kumar , Gupta Manoj Kumar 
Published: October 2023

AbstractIn this work, we have synthesized the zinc‐aluminum layered double hydroxide (ZnAl LDH) nanostructures using cost‐effective hydrothermal technique. The ZnAl LDH and graphene‐based poly(vinyl alcohol) (PVA) nanocomposites are fabricated. The crystal structure, morphology, thermal, and dielectric properties of pristine PVA and ZnAl LDH and graphene‐based PVA nanocomposites films were investigated using X‐ray diffraction, HR‐transmission electron microscopy, thermo gravimetric analysis, and impedance analyzer. HRTEM analysis reveals the hexagonal nanoplates shape‐like morphology of Zn‐Al layered double hydroxides with an average thickness of 40–50 nm and size of 400–600 nm. High thermal stability was observed from ZnAl LDH and graphene‐reinforced nanocomposite. Enhanced thermal stability of 250°C and low weight loss was observed from ZnAl LDH reinforced PVA‐based nanocomposites compared to pristine PVA. Zn‐Al LDH nanoplates‐graphene‐PVA based nanocomposites showed ultra‐high dielectric constant (ɛ′) of 794 as compared to the ZnAl LDH‐PVA nanocomposites (ɛ′ ~ 334) and pristine PVA sample (ɛ′ ~ 35). Low dielectric loss of 0.27, 0.18, 0.38 was observed for pristine PVA, ZnAl‐LDH‐PVA and ZnAl‐LDH‐graphene‐PVA nanocomposites. The large enhancement of the dielectric constant and thermal stability were discussed in terms of improved crystallinity, interfacial polarization and formation of nanodipoles in the matrix. This study reveals a significant role of LDH‐graphene‐based hybrid nanocomposites in optoelectronics, energy storage, sensors, energy conversion and thermally stable devices.Highlights
Growth of highly crystalline zinc‐aluminum layered double hydroxide nanostructures.
Improved thermal stability for Zn‐Al LDH‐graphene‐PVA nanocomposites.
High thermal stability from ZnAl LDH‐based PVA nanocomposites.
Ultra‐high dielectric constant of 794 is observed from Zn‐Al LDH nanoplates‐graphene‐nanocomposites.
Use of a custom‐made acetabular cage to treat aseptic loosening following cemented total hip replacement in a giant breed dog
Authors: Roels Joséphine , Baldinger Arnaud , Viguier Éric , Cachon Thibaut 
Published: October 2023

AbstractA 7‐year‐old, female, spayed Dogo Argentino was presented with right hindlimb lameness 9 months following right total hip replacement. Investigations identified loosening of the acetabular cup and significant loss of bone stock, including defects of the dorsal acetabular rim and caudal pillar. A custom‐made acetabular cage inspired from the human acetabular reinforcement ring was implanted and fixed into the ilium and the acetabular rim with screws. Improvement in right hindlimb function was delayed by the occurrence of a right cranial cruciate ligament rupture; however, radiography 6 months following the surgery demonstrated osseointegration despite loosening of a single screw. Three years postoperatively, the dog showed no resentment on manipulation of the right hip and the owners reported a return to normal activity including off‐lead running. Aseptic cup loosening associated with acetabular medial wall and caudal pillar defect were ameliorated using a custom‐made acetabular cage in a giant breed dog.
Hepatic amyloidosis in a dog with sterile pyogranulomatous lymphadenitis
Authors: Herr Jacob , Piviani Martina , Koranda Walsh , Porat‐Mosenco Yael , Silvestrini Paolo 
Published: October 2023

AbstractA 3‐year‐old, mixed breed dog was presented for chronic large intestine diarrhoea, hyporexia, weight loss, fever, generalised lymphadenopathy and progressive abdominal distention, caused by hepatomegaly and ascites. Cytology of peripheral lymph nodes and liver was suggestive of pyogranulomatous lymphadenitis and hepatic amyloidosis, respectively. As concurrent infectious and/or neoplastic diseases were ruled out, and the dog responded favourably to immunosuppressive therapy, a sterile idiopathic pyogranulomatous lymphadenitis triggering amyloid deposition in the liver was considered a likely diagnosis. The dog developed clinical signs and clinicopathological abnormalities suggestive of hepatic failure 11 months later and was euthanased at that stage. Unfortunately, hepatic amyloidosis is associated with a poor prognosis due to lack of an effective therapy and consequent progressive organ failure and/or organ rupture causing life‐threatening haemorrhage.
Analysis of the Veterinary Risk Assessment and Management Plan questionnaire responses for dairy herds enrolled in the Northern Ireland Johne's disease control programme
Authors: Meek Kayleigh , Strain Sam , O'Connell Niamh E. , Grant Irene R. 
Published: October 2023

AbstractBackgroundAnimal Health and Welfare Northern Ireland has been enrolling dairy herds across Northern Ireland (NI) in a voluntary Johne's disease (JD) control programme since October 2020. A Veterinary Risk Assessment and Management Plan (VRAMP) questionnaire was completed for each herd enrolled and recommendations for improved farm management practices were provided to farmers. Herd JD testing was recommended but was not mandatory.MethodsThis study analysed VRAMP responses for 1569 dairy herds that had enrolled in the JD control programme up to October 2022. Univariate and multivariate regression models were applied to the data as appropriate.ResultsOverall, 21.4% of the dairy herds had completed herd JD screening, with 13.7% of herds reporting a confirmed case of JD. A further 31.5% of herds reported suspected case(s) of JD. Eighty‐nine percent of farms had introduced animals from outside the herd. Herds that utilise a mixed calving pen and hospital pen, and herds that do not separate JD‐positive or sick animals within the calving pen, were significantly (p > 0.001) more likely to be a high‐probability JD herd. Accidental mixing of neighbouring herds significantly (p = 0.01) increased the risk of a suspected or confirmed case of JD. Herds that utilise rented land (70%) were significantly (p > 0.001) more likely to be at a high risk for JD.ConclusionsThe VRAMP analysis identified areas of JD control that should be focused on in NI dairy herds, such as calving pen management and hygiene. The results highlight the importance of common JD recommendations in the management of on‐farm disease risk.
Synthesis of Organosilicon‐Based Thioether Ligand Class Showing Defined S‐Stereogenic Coordination in Crystalline Palladium(II) Complexes
Authors: Schneider Paul Erik , Wattenberg Jonathan , Wappelhorst Jan Frederick , Knorr Michael , Strohmann Carsten 
Published: October 2023

AbstractA synthesis route to aromatic organosilicon‐based thioether ligands could be established and utilised for three congeners 2. These ligands were suitable for complexation with palladium(II) chloride forming three new complexes 3. The single crystal X‐ray diffraction and temperature‐dependent 1H and 13C‐NMR analysis of 3 are presented. The elucidated solid‐state structures suggested that one pair of diastereomers is favoured in crystalline phase and is controllable by the aromatic substituent. However, at room temperature in solution, the conformation at the sulphur atoms can fluctuate with a coalescence temperature for 1H‐NMR around 24 °C. At −31 °C, two signal sets could be observed since the inversion is slower than the 1H‐NMR timescale at lower temperatures.
An Introduction to Magnetic Tweezers
Authors: Dulin David 
Published: October 2023

AbstractMagnetic tweezers are a single-molecule force and torque spectroscopy technique that enable the mechanical interrogation in vitro of biomolecules, such as nucleic acids and proteins. They use a magnetic field originating from either permanent magnets or electromagnets to attract a magnetic particle, thus stretching the tethering biomolecule. They nicely complement other force spectroscopy techniques such as optical tweezers and atomic force microscopy (AFM) as they operate as a very stable force clamp, enabling long-duration experiments over a very broad range of forces spanning from 10 fN to 1 nN, with 1–10 milliseconds time and sub-nanometer spatial resolution. Their simplicity, robustness, and versatility have made magnetic tweezers a key technique within the field of single-molecule biophysics, being broadly applied to study the mechanical properties of, e.g., nucleic acids, genome processing molecular motors, protein folding, and nucleoprotein filaments. Furthermore, magnetic tweezers allow for high-throughput single-molecule measurements by tracking hundreds of biomolecules simultaneously both in real-time and at high spatiotemporal resolution. Magnetic tweezers naturally combine with surface-based fluorescence spectroscopy techniques, such as total internal reflection fluorescence microscopy, enabling correlative fluorescence and force/torque spectroscopy on biomolecules. This chapter presents an introduction to magnetic tweezers including a description of the hardware, the theory behind force calibration, its spatiotemporal resolution, combining it with other techniques, and a (non-exhaustive) overview of biological applications.
Single-Molecule Fluorescence Microscopy in Sensory Cilia of Living Caenorhabditis elegans
Authors: Loseva Elizaveta , van Krugten Jaap , Mitra Aniruddha , Peterman Erwin J. G. 
Published: October 2023

AbstractIntracellular transport of organelles and biomolecules is vital for several cellular processes. Single-molecule fluorescence microscopy can illuminate molecular aspects of the dynamics of individual biomolecules that remain unresolved in ensemble experiments. For example, studying single-molecule trajectories of moving biomolecules can reveal motility properties such as velocity, diffusivity, location and duration of pauses, etc. We use single-molecule imaging to study the dynamics of microtubule-based motor proteins and their cargo in the primary cilia of living C. elegans. To this end, we employ standard fluorescent proteins, an epi-illuminated, widefield fluorescence microscope, and primarily open-source software. This chapter describes the setup we use, the preparation of samples, a protocol for single-molecule imaging in primary cilia of C. elegans, and data analysis.
Introduction—Jalan Nao
Authors: Tuyen Quang Dai 
Published: October 2023

AbstractI still recall my first visit to the Po Rome temple during the Katé festival 32 years ago. As a child, my grandfather, who was well-versed in history, folk stories, and oral traditions, often regaled me and my friends with tales of the Cham people, their kings, and temples. I remember seeing the temple on top of the hill from our village and feeling its sacredness, a sentiment shared by my parents and community. Although I was too young to fully appreciate it, my family did not take me to the temple for spiritual worship during any ceremonies or festivals.
Living Heritage in the Everyday: Roles of Po Klaong Girai Temple in the Cham Community
Authors: Tuyen Quang Dai 
Published: October 2023

AbstractThe chapter “Living Heritage in the Everyday” offers a compelling illustration of how the sacred temple heritage has been seamlessly integrated into the daily lives of the Cham people, playing a crucial role in their cultural, spiritual, and social aspects. By incorporating the symbol of the sacred temple into various aspects of their everyday life, such as in wedding ceremonies and community group logos, the Cham have sparked a renewed sense of cultural pride and heritage among the younger generation. This has enabled them to understand and appreciate their cultural identity and the importance of preserving and promoting their cultural heritage.Furthermore, the chapter sheds light on how the Cham people have developed a profound sense of pride in their sacred temple, making it more accessible and integrated into everyday life within the Cham community. In doing so, they have ensured that the symbol of their cultural heritage remains unblemished and highly respected. The successful preservation of the Cham cultural heritage in this way is a testament to their unwavering determination to celebrate and safeguard their cultural identity. The chapter offers an inspiring example of how cultural heritage can be developed and incorporated into everyday life to engage and preserve the members of a community.
Balancing Authenticity and Tourism Development: The Challenge of Incense at Cham Temples
Authors: Tuyen Quang Dai 
Published: October 2023

AbstractIn this chapter, the focus is on the perspectives of the Cham community in Vietnam with regard to the concept of authenticity. The study, conducted between 2012 and 2017, revealed instances of the Vietnamese government officials imposing their own interpretations of authenticity on the Cham communities and their living heritage sites to meet the expectations of tourists.
Glauber phases in non-global LHC observables: resummation for quark-initiated processes
Authors: Böer Philipp , Neubert Matthias , Stillger Michel 
Published: October 2023

Abstract
It has been known for many years that jet cross sections at hadron colliders exhibit double-logarithmic corrections starting at four-loop order, arising from two soft Glauber-gluon interactions between the two colliding partons. The resummation of these “super-leading logarithms” has been achieved only recently by means of a renormalization-group treatment in soft-collinear effective theory. We generalize this result and, within the same framework and for quark-initiated processes, resum the double logarithms arising in the presence of an arbitrary number of Glauber-gluon exchanges. For typical choices of parameters, the higher-order Glauber terms give rise to corrections which are expected to be numerically of the same magnitude as the super-leading logarithms. However, we find that the Glauber series for jet cross sections is dominated by the two-Glauber contribution, if the colliding partons are quarks or anti-quarks.