bluuebunny/crossref_metadata_2025_split huggingface dataset:
Reassessing the Role of Phonomicrosurgery and Smoking Status in the Management of Reinke's Edema
Authors: Quinton Brooke A. , Arianpour Khashayar , Yaffe Noah M. , Tierney William S. , Benninger Michael S. , Bryson Paul C. 
Published: November 2023

ObjectivesTo elucidate recurrence patterns of Reinke's edema (RE) following phonomicrosurgery and compare current and former smokers' outcomes.MethodsA retrospective chart review was performed for patients who underwent microflap excision for RE at our institution since 2008. Patient data were collected, including demographics, smoking history, and operative and voice outcomes during the available follow‐up period. Descriptive statistics, student's t‐tests, Chi‐squared analyses, and Fischer's exact tests were used for the appropriate between‐group comparisons utilizing JMP statistical software.ResultsPatients who quit smoking on the day of surgery or continued to smoke postoperatively were included in our group of current smokers (n = 56). Patients who quit smoking within the month of surgery or longer were included in our group of former smokers (n = 22). There was no significant difference in postoperative voice outcomes between groups. Eight patients in the entire cohort experienced recurrence during the available follow‐up period. Fischer's exact test revealed no statistically significant association between smoking status and recurrence (two‐tailed p > 0.05). The mean time to recurrence for current smokers who did recur was 69 and 54 months for former smokers.ConclusionWe report low overall recurrence rates after microflap excision of RE lesions compared with historical data, without any significant difference in recurrence or voice outcomes when comparing current and former smokers. Further prospective trials with larger sample sizes are warranted to guide the surgical management of RE patients and the implications of smoking status.Level of Evidence.3 Laryngoscope, 134:2659–2663, 2024
Stable carbon isotopic composition of amino sugars in heterotrophic bacteria and phytoplankton: Implications for assessment of marine organic matter degradation
Authors: Guo Jinqiang , Achterberg Eric P. , Shen Yuan , Yuan Huamao , Song Jinming , Liu Jin , Li Xuegang , Duan Liqin 
Published: November 2023

AbstractCompound‐specific isotope analysis has opened up a new realm for resolving the sources and transformation processes of marine organic matter. However, the stable carbon isotope patterns of amino sugars remain unknown. We examined δ13C of amino sugars in marine phytoplankton and heterotrophic bacteria, and the variations in amino sugar δ13C during 66‐d planktonic organic matter degradation experiments, to investigate the metabolic sources and transformations of amino sugars by bacterial reworking. The δ13C values of glucosamine (GlcN) and galactosamine (GalN) were comparable in heterotrophic bacteria (difference Δδ13CGlcN–GalN = 0.4–4.0‰) but pronouncedly different in phytoplankton (Δδ13CGlcN–GalN = 4.3–16.6‰), suggesting similar synthesis pathways of GlcN and GalN in bacteria that differed from phytoplankton. Compared to GlcN and GalN, bacteria preferentially use isotopically light organic compounds for muramic acid (MurA) synthesis. During simulated microbial degradation of organic matter, the δ13C difference between GlcN and GalN decreased from 5.8‰ on the initial day to 1‰ at a late stage in the experiment, but the difference between GlcN and MurA remained at 5.3‰. This difference is consistent with the pattern in cultured phytoplankton (average Δδ13CGlcN–GalN = 5.9‰ ± 1.4‰) and heterotrophic bacteria (average Δδ13CGlcN–MurA = 4.6‰ ± 3.4‰), indicating enhanced bacterial resynthesis as degradation proceeded. Based on the difference in δ13C among GlcN, GalN, and MurA, we propose a novel index of variation in amino sugar δ13C, representing amino sugar resynthesis, to describe the diagenetic state of organic matter. Together, these findings suggest that amino sugar δ13C can be used as a new tool to track heterotrophic processes of marine organic matter.
Bottom‐Up Extrusion‐Based Biofabrication of the Osteoid Niche
Authors: Parmentier Laurens , D'Haese Sophie , Carpentier Nathan , Dmitriev Ruslan I. , Van Vlierberghe Sandra 
Published: November 2023

AbstractBone regeneration remains a clinical challenge given the transplantation incidence rate and the associated economic burden. Bottom‐up osteoid tissue engineering has the potential to offer an alternative approach to current clinical solutions that suffer from various drawbacks. In this paper, deposition‐based bioprinting is exploited while the effect is explored of both the crosslinking mechanism (gelatin methacryloyl (GelMA) versus gelatin norbornene (DS 91) crosslinked with thiolated gelatin (GelNBSH)) and the degree of substitution (GelNBSH versus norbornene‐norbornene‐modified gelatin (DS 169) crosslinked with thiolated gelatin (GelNBNBSH)) on the presented biophysical cues as well as on the osteogenic differentiation. The incorporation of tris(2‐carboxyethyl)phosphine (TCEP) to the step‐growth inks allows the production of reproducible and biocompatible scaffolds based on thiol‐ene chemistry. Dental pulp stem cell encapsulation in GelNBNBSH biofabricated constructs shows a favorable response due to the combination of its stress relaxation and substrate rigidity (bulk compressive modulus of 11–30 kPa) as reflected by a sevenfold increase in calcium production compared to the tissue engineering standard GelMA. This work is the first to exploit a controlled biocompatible and cell‐interactive thiolated macromolecular crosslinker (GelSH + TCEP) allowing the extrusion‐based biofabrication of low concentration (5 w/v%) modified osteogenic gelatin‐based inks (GelNBNBSH + TCEP).
3D Printed Tubulointerstitium Chip as an In Vitro Testing Platform
Authors: Addario Gabriele , Eussen Daphne , Djudjaj Sonja , Boor Peter , Moroni Lorenzo , Mota Carlos 
Published: November 2023

AbstractChronic kidney disease (CKD) ranks as the twelfth leading cause of death worldwide with limited treatment options. The development of in vitro models replicating defined segments of the kidney functional units, the nephrons, in a physiologically relevant and reproducible manner can facilitate drug testing. The aim of this study was to produce an in vitro organ‐on‐a‐chip platform with extrusion‐based three‐dimensional (3D) printing. The manufacturing of the tubular platform was produced by printing sacrificial fibers with varying diameters, providing a suitable structure for cell adhesion and proliferation. The chip platform was seeded with primary murine tubular epithelial cells and human umbilical vein endothelial cells. The effect of channel geometry, its reproducibility, coatings for cell adhesion, and specific cell markers were investigated. The developed chip presents single and dual channels, mimicking segments of a renal tubule and the capillary network, together with an extracellular matrix gel analogue placed in the middle of the two channels, envisioning the renal tubulointerstitium in vitro. The 3D printed platform enables perfusable circular cross‐section channels with fully automated, rapid, and reproducible manufacturing processes at low costs. This kidney tubulointerstitium on‐a‐chip provides the first step toward the production of more complex in vitro models for drug testing.
Logistics service strategy for e‐commerce supply chain: Interactive impacts of cost reduction effort and fairness concern
Authors: Chen Lin , Dong Ting , Pang Mo , Liu Qiurui , Wang Zhongrui , Rao Congjun 
Published: November 2023

AbstractIn recent years, the logistics industry has undergone tremendous development because of the growth of e‐commerce, providing supply chain members with various options for logistics service strategies. Furthermore, cost reduction effort (CRE) and fairness concern have become even more significant on the logistics operation for e‐commerce supply chain because of changing market conditions and consumer demands. Considering CRE and fairness concern, we propose a Stackelberg game model where the manufacturer acts as a leader to analyze how a manufacturer or a retailer strategically decides between two logistics service strategies, i.e., the manufacturer‐provided logistics service and the retailer‐provided logistics service. When the retailer provides logistics service in the absence of fairness concern, a “win‐win” outcome can be achieved. However, profit does not always increase in proportion to the logistics service cost factor when fairness concern is considered. Additionally, there is a situation where the optimal logistics service strategy for the manufacturer and the retailer is contrary to each other in different ranges of fairness concern intensity when the logistics service provider both has CRE and fairness concern. As a consequence, it becomes important for both the manufacturer and the retailer to balance their fairness concern and consider the effectiveness of CRE when making decisions about adopting logistics service strategy.
Improving seasonal prediction of summer rainfall over southern China using the BCC_CSM1.1m model‐circulation increment‐based dynamic statistical technique
Authors: Zhou Fang , Han Weiming , Zhang Dapeng , Cao Rong 
Published: November 2023

AbstractA model‐circulation increment‐based dynamic statistical technique (MIDST) is proposed in this paper to improve the prediction of summer rainfall over southern China (SC) where quite low prediction skills have been found in the Beijing Climate Center Climate System Model version 1.1 with a moderate resolution (BCC_CSM1.1m). The results show that BCC_CSM1.1m can hardly represent the variability of the summer rainfall anomaly and its year‐to‐year increment over SC, and the skillful predictions are mostly confined over the middle reaches of the Yangtze River. Using the dynamic model output and statistical method, the MIDST is established to capture the coupled modes between the year‐to‐year increments of the summer rainfall anomaly and the associated simultaneous three‐dimensional coupled air‐sea circulation predictors. The cross‐validation indicates that the prediction skills of the MIDST are evidently improved for both the summer rainfall increment prediction and summer rainfall anomaly prediction compared with the direct BCC_CSM1.1m prediction. The skillful prediction can persist for long forecast leads over most regions except southwestern China. As the major predictability source of seasonal prediction, the intense response to changes in the circulation related to the El Niño‐Southern Oscillation (ENSO) is well captured, and thus, the performance improvement of the MIDST is primarily due to its more realistic representation of the incremental circulation related to the ENSO.
Tunable absorptive bandpass filter with two transmission zeros based on image parameter method
Authors: Cho Young‐Ho , Park Cheolsoo 
Published: November 2023

AbstractA tunable absorptive bandpass filter with two transmission zeros is presented. A lowpass absorptive filter prototype consisting of a matching section and a m‐drive filter section is established based on image parameter method, and the filter elements are easily derived through the image impedance with the required return loss and transmission zeros. Moreover, the two transmission zeros are controlled by adjusting the parameters of the m‐drive filter section. A distributed tunable absorptive bandpass filter is realized based on the proposed lowpass filter prototype. The fabricated filter shows a return loss of 21–25 dB and an insertion loss of 2.1–2.8 dB at the center frequency within the tuning range of 1.35–1.58 GHz.
Proposed standard weight (W
s) equation and standard length categories for Goldeye
Authors: Miller Brett T. , Renner Elizabeth A. , Winders Kyle R. , Wellemeyer Juju C. , Kim Hae H. 
Published: November 2023

Abstract

Objective
Goldeye Hiodon alosoides relative weight (Wr) and proportional size distribution (PSD) have not been able to be evaluated in populations across their range. The objective of this project was to develop and assess standard weight (Ws) equations with three different techniques along with developing standard length categories for Goldeye.

Methods
Length and weight data for 64,435 Goldeye Hiodon alosoides from 96 populations across Canada and the United States were collected to develop a Ws equation. We developed standard weight equations for Goldeye with the regression-line-percentile (RLP), empirical-percentile linear (EmP-L), and empirical-percentile quadratic (EmP-Q) techniques.

Result
We propose the RLP equation as log10W = 2.979 × log10L − 4.979, the EmP-L equation as log10W = 3.048 × log10L − 5.151, and the EmP-Q equation as log10W = 1.254 × log10L + 0.365 × (log10L)2 − 2.950, where W is weight (g) and L is total length (TL, mm). We also developed PSD length categories of 13, 20, 26, 33, and 40 cm TL representing stock, quality, preferred, memorable, and trophy categories, respectively.

Conclusion
These Ws equations and standard length categories will aid fisheries biologists in assessing Goldeye populations holistically across their range when developing management strategies.
How we approach sharing child–caregiver PRO disagreement
Authors: Porter Amy S. , Hinds Pamela S. , Wiener Lori , Thompson Amanda L. , Weaver Meaghann S. 
Published: November 2023

AbstractResearchers use patient‐reported outcomes (PRO) to capture the patient experience, and in pediatrics, parent report of symptom and function often accompanies the child's assessment. Children with cancer and their family caregivers frequently evaluate symptom burden and functional status differently. Child–caregiver PRO disagreement often worries pediatric oncology clinicians, who do not know how to best approach sharing it with families. Openly discussing differences in symptom and functional status reporting is a crucial element of supporting families and can improve family harmony throughout the child's illness journey. This paper offers strategies and language for communicating with families about PRO disagreement.
The effect of altered pH growth conditions on the production, composition, and proteomes of Helicobacter pylori outer membrane vesicles
Authors: Johnston Ella L. , Guy‐Von Stieglitz Sebastian , Zavan Lauren , Cross Jonathon , Greening David W. , Hill Andrew F. , Kaparakis‐Liaskos Maria 
Published: November 2023

AbstractGram‐negative bacteria release outer membrane vesicles (OMVs) that contain cargo derived from their parent bacteria. Helicobacter pylori is a Gram‐negative human pathogen that produces urease to increase the pH of the surrounding environment to facilitate colonization of the gastric mucosa. However, the effect of acidic growth conditions on the production and composition of H. pylori OMVs is unknown. In this study, we examined the production, composition, and proteome of H. pylori OMVs produced during acidic and neutral pH growth conditions. H. pylori growth in acidic conditions reduced the quantity and size of OMVs produced. Additionally, OMVs produced during acidic growth conditions had increased protein, DNA, and RNA cargo compared to OMVs produced during neutral conditions. Proteomic analysis comparing the proteomes of OMVs to their parent bacteria demonstrated significant differences in the enrichment of beta‐lactamases and outer membrane proteins between bacteria and OMVs, supporting that differing growth conditions impacts OMV composition. We also identified differences in the enrichment of proteins between OMVs produced during different pH growth conditions. Overall, our findings reveal that growth of H. pylori at different pH levels is a factor that alters OMV proteomes, which may affect their subsequent functions.
Recommending instead of taking down: YouTube hyperpartisan content promotion amid the Brazilian general elections
Authors: Santini Rose Marie , Salles Débora , Mattos Bruno 
Published: November 2023

AbstractYouTube released a global commitment to reduce the spread of problematic content by actively recommending “trusted” news sources on their platform but did not disclose the criteria used to classify the reputation of channels and the list of trusted news sources favored by the company. We aim to understand the patterns of recommendation by YouTube's algorithm and identify what the platform classifies as “reliable informative sources.” In our experiment, we performed 205 tests on YouTube's recommendation system, simulating the behavior of new Brazilian users with no historical data on the platform looking for reliable news throughout the elections. We documented the Brazilian media groups that were suggested on the homepage, further analyzing the presence, position and content of Jovem Pan videos, Brazil's flagship conservative media group. We identified that, far from reigning in extremist content, YouTube systematically prioritized Jovem Pan and did not actively take down toxic Jovem Pan content. Our findings indicate that YouTube magnified the imbalance between candidates' portrayals, exposing the regulatory asymmetry between broadcast media and online platforms in the country. In spite of the opaque commercial agreements and business strategies, the platform's recommendation decisions may have an “advertising effect” of sponsorship and endorsement on users.
On the chemistry of furfuryl alcohol polymerization: A review
Authors: Iroegbu Austine Ofondu Chinomso , Ray Suprakas Sinha 
Published: November 2023

AbstractThis review dives into the intricate chemistry of furfuryl alcohol (FA) polymerization, a critical process for producing FA‐based resins (oligomers and polymers). Despite over a century of studies, the complexity of FA resinification continues to intrigue scientists, engendering extensive discourses. The inherent complexity and heterogeneity of FA resins have thwarted attempts to propose a universally applicable structural elucidation, prompting the investigation of numerous proposed mechanisms. Drawing upon an extensive corpus of literature, we survey various proposed mechanisms and representative structural attributes of a range of FA polymeric systems. The insights from a rich tapestry of experimental evidence collectively illuminate the manifold intermediates and pathways that characterize various FA polymerization techniques. A critical appraisal of prevailing debates and counterarguments offers a nuanced perspective on the diverse facets of FA polymerization chemistry. Moreover, this work underscores the latent potential of biobased chemistry, from the perspective of furan chemistry, as a potent catalyst for driving the essential objectives of de‐fossilization and sustainability within the chemical and materials industries. Subsequently, it provides valuable insights into the present state of knowledge on FA polymerization, thereby serving as a vanguard for delineating future research trajectories in this captivating field.
Cancer‐related stress in childhood cancer survivorship: Prevalence and associations with perceptions of health risks and quality of life
Authors: Himelhoch Alexandra C. , Olsavsky Anna L. , Darow Eva L. , Lipak Keagan G. , Kenney Ansley E. , Fisher Rachel S. , Prussien Kemar V. , Vannatta Kathryn A. , Compas Bruce E. , Gerhardt Cynthia A. 
Published: November 2023

AbstractObjectiveLimited research has characterized cancer‐related stress (CRS) among families of childhood cancer survivors. We examined the prevalence of CRS among survivors and caregivers, as well as its association with health risk perceptions (i.e., prognosis, risk for diminished quality of life) and views of survivor quality of life (QoL).MethodsAt five years post‐diagnosis or relapse, survivors (n = 100; Mage = 15.84 years; 89% White), mothers (n = 127), and fathers (n = 59) reported their CRS. Perceived prognosis and risk for diminished QoL were rated on a 0%–100% visual analogue scale, while the PedsQL assessed QoL.ResultsCRS was low (M = 1.6–1.8, scale: 1–4); mothers reported greater stress than survivors, p = 0.038, d = 0.25. There was an indirect effect of survivors' perceived prognosis on their QoL through CRS, CI = 0.04 to 0.25, R2 = 0.32. Among mothers, there was an indirect effect of perceived prognosis/risk for diminished QoL on their reports of survivor QoL through CRS, CI = 0.03 to 0.23 and −0.15 to −0.03, R2 = 0.28 and 0.32, respectively. There were no indirect effects among fathers.ConclusionsCRS may be an important, modifiable factor that could improve survivors' QoL. Research is needed to examine how CRS changes over time to assess the utility of interventions among female survivors, mothers, and those with lower prognosis estimates.
Healthcare costs and resources utilization in children with difficult‐to‐control asthma treated with biologic therapies: A population‐based cohort study
Authors: Monzio Compagnoni Matteo , Conflitti Claudia , Capuano Veronica , Bonaiti Giulia , Franchi Matteo , Vimercati Chiara , Biondi Andrea , Luppi Fabrizio , Corrao Giovanni , Faverio Paola 
Published: November 2023

AbstractIntroductionAsthma is one of the most common diseases in children, with a variable range of severity. In recent years, treatment for severe asthma has been largely improved by the availability of targeted biologic therapies. Nevertheless, studies reporting real‐world data and cost‐effectiveness analyses are lacking. The aim of this study was to evaluate, on a population‐based cohort of children with asthma, the impact of the treatment with biologics on healthcare service utilization and associated costs.MethodsData were retrieved from Healthcare Utilization database of Lombardy region (Italy). A cohort of 46 asthmatic children aged 6–11 in treatment with dupilumab, mepolizumab or omalizumab was identified during 2017–2021. We compared healthcare resources use between the year before (“baseline period”) and the year after the treatment initiation (“follow‐up period”). Average 1‐year healthcare costs were also calculated.ResultsComparing the baseline with the follow‐up period, the number of patients with at least one exacerbation‐related hospitalization and ER access decreased by 75.0% and 85.7%, respectively. The use of biologic agents, namely omalizumab, mepolizumab and dupilumab, significantly reduced oral corticosteroids (OCS), short‐acting β2‐agonists and the association inhaled corticosteroids/long‐acting β2‐agonists use. ER admissions for non‐respiratory causes were also significantly reduced, while discontinuation rate was low (6.5%). The overall costs increased, due to the costs of the biologic agents, but the hospital admission‐related costs due to respiratory causes reduced significantly.ConclusionsOur real‐world investigation suggests that biologic agents reduced hospital admissions for respiratory causes and use of anti‐asthmatic drugs, including OCS. However, long‐term healthcare sustainability still needs more in‐depth assessments.