bluuebunny/crossref_metadata_2025_split huggingface dataset:
Early life stress paired with adolescent alcohol consumption reduces two‐bottle choice alcohol consumption in mice
Authors: Perry Thomas W. , Carvour Harrison M. , Reichert Amanda N. , Sneddon Elizabeth A. , Roemer Charlotte A. E. G. , Gao Ying Ying , Schuh Kristen M. , Shand Natalie A. , Quinn Jennifer J. , Radke Anna K. 
Published: January 2025

AbstractBackgroundIn humans, early life stress (ELS) is associated with an increased risk for developing both alcohol use disorder (AUD) and posttraumatic stress disorder (PTSD). We previously used an infant footshock model in rats that produces stress‐enhanced fear learning (SEFL) and increases aversion‐resistant alcohol drinking to explore this shared predisposition. The goal of the current study was to test the viability of this procedure as a model of comorbid PTSD and AUD in male and female C57BL/6J mice.MethodsAcute ELS was induced using 15 footshocks on postnatal day (PND) 17. In adulthood, alcohol drinking behavior was tested in one of three two‐bottle choice drinking paradigms. In continuous access, mice were given 24 h access to 5% and 10% ethanol and water for five consecutive drinking sessions each. In limited access drinking in the dark, mice were given 2 h of access to 15% ethanol and water across 15 sessions 3 h into the dark cycle. In intermittent access, mice were presented with 20% ethanol and water Monday, Wednesday, and Friday, for four consecutive weeks. In a fifth week of intermittent access drinking, increasing concentrations of quinine (10, 100, and 200 mg/L) were added to the ethanol to test aversion‐resistant drinking. Intermittent access drinking was tested with and without a period of adolescent drinking (PND 35).ResultsInfant footshock did not alter drinking in the continuous or limited access tasks. In the intermittent access task, adult consumption and preference were lower in shocked mice when adolescent drinking was included. Aversion resistance was greater in females following infant footshock and adolescent drinking.ConclusionsOur results demonstrate that ELS, in the form of infant footshock on PND 17, must be followed by a period of adolescent drinking to affect adult alcohol consumption in mice.
How stable and predictable are welfare estimates using recreation demand models?
Authors: Lloyd‐Smith Patrick , Zawojska Ewa 
Published: January 2025

AbstractEconomic analyses of environmental policy projects typically use pre‐existing estimates of welfare measures that are then transferred over time to the policy relevant periods. Understanding how stable and predictable these welfare estimates are over time is important for applying them in policy. Yet, revealed preference models of recreation demand have received few temporal stability assessments compared to other nonmarket valuation methods. We use a large administrative panel dataset on campground reservations covering 10 years to study temporal stability and predictability of environmental quality welfare estimates. Welfare estimates are statistically different across years in 62% of the comparisons, and this ranges from 47%–71% depending on modeling assumptions. Using an event study design, we find evidence that week‐specific welfare estimates are stable after an initial adjustment week in response to a change in environmental quality. Our findings further reveal that using 2 years of data in the modeling compared to a single year improves the prediction of future welfare measure estimates substantially, but further prediction improvements are modest when including more than 2 years of data. Predictions of welfare estimates are more consistent when using data closer in time to the prediction year. We discuss the implications of our results for using revealed preference studies in policy analysis.
Oral and Gut Microbial Hubs Associated With Reaction Threshold Interact With Circulating Immune Factors in Peanut Allergy
Authors: Zhang Lingdi , Chun Yoojin , Grishina Galina , Lo Tracy , Reed Kyle , Wang Julie , Sicherer Scott , Berin M. Cecilia , Bunyavanich Supinda 
Published: January 2025

ABSTRACTBackgroundAmong peanut‐allergic individuals, there is high variability in the amount of peanut that triggers reactions (i.e., reaction threshold) that is not predictable or well‐understood. We conducted this study to characterize relationships between the oral and gut microbiomes and systemic processes associated with reaction threshold in peanut allergy (PA).MethodsIn a cohort of 120 children with suspected PA who underwent double‐blind, placebo‐controlled food challenges, we generated and analyzed parallel profiles of the oral microbiome, gut microbiome, peripheral blood transcriptome, peripheral blood cytometry, and serum antibody levels to identify threshold‐associated markers and their inter‐relationships.ResultsThe 120 participants included 23 children with no PA, 74 with high‐threshold PA (reacting to ≥ 443 mg cumulative peanut protein), and 23 with low‐threshold PA (reacting to < 443 mg cumulative peanut protein). Ten hub microbes were each identified in saliva and stool microbiome networks that were constructed, including the hub microbes Rothia aeria in saliva and Bacteroides sp. in stool that were associated with reaction threshold. These hub microbes were also associated with peripheral blood transcript levels for threshold‐associated key drivers of FcγR‐mediated phagocytosis and TLR signaling. Correlation network construction with additional data on threshold‐associated peripheral blood neutrophil abundance and peanut‐specific serum IgE and Ara h 2 antibody levels revealed central roles for saliva Rothia aeria and stool Bacteroides sp. in local‐systemic networks for IgE‐ and IgG‐mediated peanut allergy.ConclusionsThis integrated study of oral and stool microbiomes, blood transcriptome, cellular profiles, and peanut‐specific serum antibodies revealed new relationships between local microbiota and systemic measures associated with reaction threshold in peanut allergy.
Machine Perfusion Liver Preservation: Highlights From the International Liver Transplant Society 2024
Authors: Krendl Felix J. , Faria Isabella , Singh Jessica , Oberhuber Rupert , Martins Paulo N. 
Published: January 2025

ABSTRACTThe 2024 International Liver Transplantation Society (ILTS) Congress, held in Houston, Texas, brought together a dynamic, multidisciplinary community of global experts to explore and discuss cutting‐edge innovations and unmet needs in liver transplantation. Key themes included liver machine perfusion and donation after circulatory death (DCD), reflecting the ongoing effort to expand the donor pool and improve transplantation outcomes. Machine perfusion technologies, including normothermic machine perfusion (NMP), hypothermic oxygenated perfusion (HOPE), and normothermic regional perfusion (NRP) have demonstrated great promise in optimizing graft quality, mitigating ischemia–reperfusion injury, and enhancing the use of marginal and DCD liver grafts. At this year's congress a total of 63 abstracts on liver machine perfusion were presented. For this report we selected all orally presented abstracts highlighting advances in organ preservation, artificial intelligence, treatments during ex‐situ perfusion including cellular therapy as well as new the use of new biomarkers. Preclinical highlights included the potential of long‐term NMP to sustain and regenerate grafts during extended ex‐situ preservation, spontaneous defatting of steatotic grafts during LT‐NMP, the delivery of regulatory T cells to enable organ‐level immunomodulation and the removal of damage‐associated molecular patterns from porcine DCD livers during NMP. On the clinical side, key points included the progression of HOPE to IDEAL‐D Stage 4 evidence, increased transplant volumes through the application of NMP, the cost‐effectiveness of NMP as well as the utilization of very old DCD donors through NRP. Collectively, these advancements mark a transition toward dynamic, data‐driven, and personalized transplantation strategies. Machine perfusion remains central to optimizing grafts, expanding the pool of organs suitable for transplantation enhancing access to liver transplantation and improving outcomes for liver transplant recipients worldwide.
Is it in their words? Teachers' enthusiasm and their natural language in class–A sentiment analysis approach
Authors: Frenzel Anne C. , Kleen Hannah , Marx Anton K. G. , Sachs David F. , Baier‐Mosch Franziska , Kunter Mareike 
Published: January 2025

AbstractIntroductionTeacher enthusiasm is an undisputedly important characteristic of teachers, with demonstrated positive effects on student outcomes. Existing research typically operationalised teacher enthusiasm via trait‐based teacher‐ or student ratings. Strikingly little is known about how teachers' trait enthusiasm manifests in their actual in‐situ classroom behaviour. Some findings have been reported regarding teachers' nonverbal behaviours, but the links between teacher enthusiasm and teacher language are unknown so far.MethodsThe present contribution fills this research gap by applying lexicon‐based sentiment analysis to quantify teachers' emotional tone from transcribed teacher utterances obtained from video recordings of full mathematics lessons (45 min). N = 19 secondary school mathematics teachers and their N = 393 students participated in our study. We realised the sentiment analysis using Remus et al.'s emotion lexicon SentiWS (v2.0, 2019). We obtained both teacher self‐reports and student ratings to assess teachers' enthusiasm, shown habitually (trait), and during the videotaped lesson (in situ).ResultsRegarding trait enthusiasm, teachers' own, but not the students', ratings were positively linked with teachers' verbally expressed sentiment in the videotaped lesson, specifically its positive valence. Regarding in‐situ enthusiasm, associations were even larger but also did not reach significance for the student ratings.ConclusionThis is the first study to employ sentiment analysis on transcripts of German teachers' in‐class talk. Besides the quantitative links between teacher enthusiasm and their language, it also provides qualitative insights on positive emotional teacher talk in mathematics.
Diluting perceived immigration threat: When and how intersectional identities shape views of North African immigrants
Authors: Sternberg Béatrice , Yzerbyt Vincent , Badea Constantina 
Published: January 2025

AbstractIn the European context, North African immigrants are often perceived as a threat to societal values and resources. Studies suggest that intersected identities (e.g., gay North African immigrant) may dilute the threat associated with one of those social categories (e.g., North African immigrant). However, the mechanisms underlying this dilution effect remain largely misunderstood. Three studies (NTotal = 1118) examine when and how immigration threat perception can be lessened, considering immigrants' intersecting identities. Using a mediated‐moderation model, we tested the hypothesis that, when perceived value incongruence between North African and gay identities (the moderator) is high, gay North African men will be perceived as ‘less North African’ than presumptively straight North African men (i.e., low group typicality: the mediator), which in turn would be associated with lower threat perception and less prejudice. Studies 1–2 revealed that participants evaluate North African immigrant men as less threatening when described as gay (vs. not). This threat dilution effect emerges especially when participants believe that North African immigrant and gay identities are highly incongruent. Studies 2–3 show that gay North African immigrants are perceived as less associated with typical attributes of the category ‘North African immigrant’, which may account for the diminished threat.
Phylogenetic Origin of Morphologically Cryptic Species Shapes Co‐Occurrence and Sympatry Patterns
Authors: Delić Teo , Di Batista Borko Špela , Premate Ester , Rexhepi Behare , Alther Roman , Knüsel Mara , Malard Florian , Weber Dieter , Stoch Fabio , Flot Jean‐François , Fišer Cene , Altermatt Florian 
Published: January 2025

ABSTRACT

Cryptic species are an important part of freshwater biodiversity, yet it remains unclear how these species integrate into communities from local to regional geographic scales. To protect biodiversity, particularly overlooked cryptic species, an accurate understanding of the underlying processes and adequate level of protection is needed.

We analysed patterns of syntopies (local co‐occurrences) and sympatries (regional range overlap) to explore how the phylogenetic origin of cryptic species shapes biodiversity patterns. We hypothesised (i) that syntopies were more common among distantly than closely related cryptic species, and (ii) that the existing sympatries were an outcome of phylogenetic relatedness and dispersal.

The hypotheses were tested on a polyphyletic species complex of subterranean amphipod species (Niphargus rhenorhodanensis complex) by deploying molecular species delimitation, time‐calibrated phylogenies, and co‐occurrence analyses with probabilistic and generalised linear models (GLM).

The studied complex comprised 37–48 molecular operational taxonomic units (MOTUs) from nine different clades, with syntopies occurring at random or less frequently than expected. GLM indicated age of divergence did not predict species sympatries, although they emerged more frequently among MOTUs from different clades. Sympatries, however, emerged through dispersal, in MOTUs with large geographic ranges. These mostly overlapped at the foothills of the Alps, the Jura and the Central Massif.

We conclude that the observed spatial patterns are mainly driven by dispersal and presumably reflect the geographic circumstances of speciation. While species richness on a local scale may be an outcome of competition and dispersal, regional biodiversity patterns presumably arise through a clade‐level cascade of historical events, including orogeny and climatic shifts.
Correlation of the Geriatric Nutritional Risk Index (GNRI) With Other Indicators of Nutrition in Chronic Hemodialysis Patients
Authors: Kosmadakis Georges , Necoara Aura , Fuentes Fanny , Ramade Nathalie , Baudenon Julien , Deville Clemence , Enache Ioana , Gueret Claudine , Haskour Abraham 
Published: January 2025

ABSTRACTBackgroundThe GNRI (Geriatric Nutritional Risk Index1) is an index used in geriatrics to predict the risk of complications and mortality associated with malnutrition. It considers serum albumin levels and the ratio of current weight or BMI to the ideal theoretical weight/BMI.AimThe aim of this study was to evaluate this index in a population of metabolically stable chronic hemodialysis patients aged > 60 years and associate it with other nutritional markers.MethodsThe studied patient cohort was divided into two groups based on their Geriatric Nutritional Risk Index (GNRI) scores: Gr 1 with GNRI score < 97 and Gr 2 with GNRI ≥ 97. We registered the anthropometric, clinical, and biological data of the study population.ResultsOne hundred seventy‐seven patients (102 M‐75F) undergoing chronic hemodialysis were included. There were no differences in age, muscle mass estimated by bioimpedance analysis, potassium levels, phosphorus levels, and nPCR between the groups. However, there were significant differences between the two groups concerning the primary disease. Gr 1 presented with a higher prevalence of diabetes and cardiovascular comorbidities. Additionally, Gr 1 presented with lower handgrip strength (Mean ± standard deviation in kg, 19.79 ± 9.37 vs. 26.83 ± 11.63, p = 0.05), lower fat mass index estimated by bioimpedance analysis (Mean ± standard deviation in kg/m2, 7.31 ± 4.55 vs. 15.24 ± 6.47, p < 0.001), and higher CRP levels (Mean ± standard deviation in mg/l, 22.27 ± 23.49 vs. 8.13 ± 10.14, p < 0.001).ConclusionIn conclusion, the GNRI, an easy calculation tool for nutrition assessment, is associated with important nutritional status parameters in chronic hemodialysis patients.
Psoriasis in People With Skin of Color: An Evidence‐Based Update
Authors: Gkini Maria‐Angeliki , Nakamura Mio , Alexis Andrew F. , Londoño‐Garcia Angela , van de Kerkhof Peter C. M. , Doss Nejib , Griffiths Christopher E. M. , Kaufman Bridget , Kleyn Christine E. , Lebwohl Mark , Redfern Jan S. , Takeshita Junko , Rajagopalan Murlidhar , El Sayed Mahira H. 
Published: January 2025

ABSTRACTVariations in epidemiology, pathophysiology, genetics, clinical presentation, management, quality of life (QoL) impact, and access to care and research exist globally across the spectrum of individuals with psoriasis. This article aims to provide an evidence‐based update on the characteristics of psoriasis in individuals with skin of color (SOC), a population in which psoriasis data have historically been limited. A literature search was conducted from January 2018 until August 2023 in Pubmed/MEDLINE/Cochrane Library and identified studies with I‐III level of evidence using Oxford Centre for Evidence‐Based Medicine recommendations. Multiple factors (including biological and non‐biological) contribute to differences in clinical features and therapeutic nuances in patient populations with SOC. The prevalence of plaque psoriasis is lower in people with SOC but tends to be more severe. People with SOC are less likely to receive biologic treatment. Although the QoL impact of psoriasis is worse in populations with SOC than in White populations, more research is needed to elucidate variations in presentation and impact across diverse populations. An important limitation of this study is that ethnicity, race, and SOC have not been defined universally or used consistently in the literature. Available evidence provides limited information on populations with SOC outside North America, which limits generalizability across global populations. Furthering our understanding of psoriasis in individuals with SOC is crucial to improving patient care outcomes for diverse patient populations worldwide.
Confessing the One Faith in Many Tongues
Authors: Behera Marina Ngursangzeli 
Published: January 2025

AbstractThis article critically reflects on the historical and cultural implications of the Nicene Creed, focusing on its relevance in non‐Western contexts. It explores the Creed not just as a theological concept but also as a tool that has influenced both ecumenical unity and hegemonic power dynamics, especially in Indigenous and colonial encounters. After outlining the Creed's role in settling debates about the nature of the relationship between the Father and the Son, while acknowledging the Creed's later global and liturgical adoption, the article critically examines the interaction between the Nicene Creed and Indigenous faith traditions. It then reflects on a possible continuity between African traditional religions and the Christian faith, focusing on the relationship of the Father and the Son. The article concludes that creeds need to be continuously reinterpreted in diverse cultural contexts and the ecumenical fellowship and advocates for a more nuanced approach to the apostolic faith, where the Nicene Creed becomes a decolonizing tool, allowing Indigenous theological perspectives to reshape how the Christian faith interacts not only with local traditions but also with the modern world. Ultimately, the article calls for an ongoing reflection on the triune God's self‐revelation to avoid the hardening of confessions as witness into creeds as a colonizing and excluding tool.
Factors Influencing Liver Cirrhosis Progression in Wilson's Disease Patients: A Retrospective Cohort Study Over 5 Years
Authors: Peng Jieru , Zhang Lu , Dong Yao , Long Wencheng , Wang Yueshan , Zhang Qiwen , Li Zhong , Li Yaxin , Jin Qiaolin , Deng Lin , Liao Juan , Xie Linshen , Yang Chunxia 
Published: January 2025

ABSTRACTObjectivesWilson's disease (WD) is a rare autosomal recessive inherited disorder characterized by dysregulated copper metabolism, amenable to treatment with chelating agents. It manifests with hepatic and neurological symptoms, often precipitating the development of liver cirrhosis as a prominent complication. This study aims to elucidate the factors, biomarker alterations, and therapeutic modalities influencing the progression of cirrhosis in WD patients.MethodsThis retrospective cohort study utilized WD patient data from West China Fourth Hospital (May 2018–September 2023). The primary outcome was the development of cirrhosis in initially cirrhosis‐free WD patients. LASSO‐COX regression identified predictive factors. The 1:1 propensity score matching generated a matched subgroup for robust Cox regression validation.ResultsAmong 133 initially cirrhosis‐free WD patients, 47 developed cirrhosis during 35.98 (22.04–49.21) months. Significant differences were observed between the cirrhosis and non‐cirrhosis groups in age at enrollment, age at WD diagnosis, clinical symptoms, educational levels, and administration of dimercaptosuccinic acid, compound glycyrrhizin polyene, and phosphatidylcholine. Multivariate Cox regression identified age at enrollment (hazard ratio [HR]: 1.038, 95% CI: 1.002–1.075), the use of glycyrrhizin (HR: 0.421, 95% CI: 0.192–0.926), erythrocyte (HR: 0.748, 95% CI: 0.626–0.895), and platelet counts (HR: 0.993, 95% CI: 0.988–0.998) associated with cirrhosis. Robust Cox analysis on the matched subgroup confirmed these findings.ConclusionGlycyrrhizic acid emerges as a potential hepatoprotective agent for WD patients. Furthermore, the progression of cirrhosis in WD patients is characterized by advanced age and decreased baseline levels of erythrocytes and platelets, suggesting their potential utility as prognostic indicators.
Is Photosynthesis‐Derived NADPH Really a Source of 2H‐Depleted Hydrogen in Plant Compounds?
Authors: Holloway‐Phillips Meisha , Tcherkez Guillaume , Wieloch Thomas , Lehmann Marco M. , Werner Roland A. 
Published: January 2025

Summary statementWe provide evidence that photosynthetically produced NADPH is not the major source of 2H‐depletion in carbohydrates.
Does policy design matter for the effectiveness of local content requirements? A qualitative comparative analysis of renewable energy value chains
Authors: Eicke Laima 
Published: January 2025

AbstractGreen industrial policies aim to create local value from renewable energy (RE) technologies. One policy instrument includes local content requirements (LCR), which prescribe a minimum share of locally manufactured inputs for investments in RE. However, the policy effectiveness of LCR differs. While they fostered local industries with rising exports in some countries, they were less successful in others. This paper analyses whether differences in LCR's effectiveness can be explained by policy design elements and the interaction with political economy factors. The paper contributes novel insights on necessary and sufficient conditions for LCR policies' effectiveness in wind and solar energy value chains. It is based on the first qualitative comparative analysis on the topic, covering 27 cases between 1995 and 2017. The analysis reveals that LCR are only effective in fostering green domestic industries if the enforced share of locally manufactured components is not too high, or when applied in countries with related industries. Furthermore, the paper outlines combinations of policy design elements that are sufficient for policy effectiveness even in challenging political economy contexts. The insights on context‐specific policy designs for LCR effectiveness are relevant for policy design theory as well as for policymakers and industry experts.