bluuebunny/crossref_metadata_2025_split huggingface dataset:
The Role of Content Creators on Cryptocurrency Investment Decisions in Gen-Z Mediated by Digital Financial Literacy
Authors: Trevina Valisha , Kohardinata Cliff 
Published: February 2025

This study aims to analyze the influence of content creators on cryptocurrency investment decisions in generation Z, with digital financial literacy as a mediating variable. The research used quantitative methods by distributing questionnaires and obtaining 111 research samples from gen-Z who are active on social media and have experience in cryptocurrency investment. The data was processed through path analysis test and sobel test. Based on the results of the study found that the role of content has a direct correlation with investment decisions, the role of content has a significant positive effect on digital financial literacy, digital financial literacy has a significant positive effect on crypto investment decisions, and the mediating variable of digital financial literacy can mediate the effect of the role of content creators on cryptocurrency investment decisions.Keyword: Role of Content Creator; Digital Financial Literacy; and Cryptocurrency Investment
Pengembangan Modul Pembelajaran Matematika Materi Keliling dan Luas Bangun Datar Berbasis Mind Mapping untuk Kelas IV di Sekolah Dasar
Authors: Cahyani Nofita , Fadhilaturrahmi Fadhilaturrahmi , Marta Rusdial , Kusuma Yanti Yandri , Aprinawati Iis 
Published: February 2025

Penelitian ini bertujuan untuk menghasilkan modul pembelajaran matematika materi keliling dan luas bangun datar berbasis mind mapping untuk kelas IV UPT SD Negeri 016 Bangkinang Kota yang valid dan praktis. Jenis penelitian ini adalah penelitian pengembangan (Reseacrh and Development) dengan tipe 4-D yaitu define, design, development dan disseminate. Penelitian ini dibatasi hanya sampai 3-D yaitu define, design dan development karena keterbatasannya waktu. Penelitian ini dilaksanakan pada semester 1 tahun ajaran 2023/2024 dengan materi keliling dan luas bangun datar. Proses validasi modul divalidasi oleh 1 orang dosen ahli materi. Pada proses praktikalitas modul di uji coba oleh 1 orang guru dan 23 orang siswa. Pada tahap validasi modul dengan metode mind mapping memenuhi kriteria sangat valid dengan rata-rata persentase 94,79% dengan rincian pada aspek materi 94,79%. Pada tahap praktikalitas modul dengan metode mind mapping ini termasuk kriteria sangat praktis dengan rata-rata persentase 97,62% dengan rincian angket respon guru 97,72% dan angket respon siswa 97,52%. Berdasarkan hasil penelitian dapat disimpulkan bahwa modul pembelajaran matematika materi keliling dan luas bangun datar berbasis mind mapping memenuhi kriteria sangat valid dan sangat praktis untuk digunakan sebagai salah satu bahan ajar dalam pembelajaran matematika terkhususnya untuk siswa kelas IV Sekolah Dasar.
Law in the Relay Race of Social Regulation
Authors: Kashanina T. V. 
Published: February 2025

The paper is devoted to the relay race (succession) of social regulators. Their race has been going on throughout the existence of humanity. Due to the economic transformation, four stages in the development ofsociety can be distinguished. The system of social regulators is extensive (there are 12 such systems in total). Only the leaders of the relay race, or basic social norms, are subjected to detailed analysis. The basic ones are the regulators responsible for vital social relations (management or power relations, property and deviations). Leadership in the social regulation relay race belongs to customs (in primitive society), then it passes to religious norms (in agrarian society). The rules of law are becoming dominant in an industrial society. Moral norms are becoming of paramount importance in the information society. This sequence is not accidental. The author hypothesizes that it is determined by the evolution of human consciousness and corresponds to its stages. The consciousness of humanity has traveled the following path: first, humanity relied on the visual perception of the world. Then, its auditory comprehension was added. Then the humanity comprehended it through the activity and, finally, it resorted to analytical comprehension. Having fulfilled its role as the main means of regulation, a basic social regulator transfers the leadership mission to another regulator more suitable for the changed social conditions. However, the social norms that have given way to leadership continue to perform regulatory functions, but now they are of secondary nature. Humanity’s intellectual accumulations remain, and it would be wasteful to dismiss them altogether.
Uma Análise dos Determinantes da Evasão no Ensino Superior EaD
Authors: Silva Alana Ramos da , Pereira Fernanda Cristina , Mendonça Rafael de Souza , Almeida Ricardo Guilherme Monteiro de , Barbosa Everaldo Henrique dos Santos , Delgado Karina Valdivia 
Published: February 2025

O Ensino à Distância teve uma forte expansão nos últimos anos, principalmente após a Pandemia do Coronavírus. Porém, ainda enfrenta desafios, como a baixa qualidade de conteúdo e as altas taxas de evasão, especialmente entre alunos de baixa renda e com responsabilidades familiares. Nesse sentido, este artigo busca analisar os determinantes da evasão no ensino a distância do ponto de vista das instituições de ensino superior. Para isto, serão usados os dados do Censo da Educação Superior do Brasil de 2018 a 2022 e o uso de Regressão Linear Múltipla. Objetiva-se, assim, realizar esse estudo a partir dos fatores que culminam na evasão do ensino superior e mapear ações que possam ser implementadas pelas IES e pelo poder público por meio de políticas públicas. Os resultados demonstraram que as taxas de evasão variam significativamente entre as instituições e que as características de idade dos alunos, gênero e origem da escola têm um efeito significativo na evasão. Tais resultados, portanto, enfatizam a importância de abordagens multidimensionais para entender os determinantes da evasão. Além disso, constatou-se a necessidade da implementação de políticas públicas que visem atender a grupos específicos de vulnerabilidade no Ensino Superior através da EaD, como mulheres e egressos de escolas públicas.

Palavras-chave: Evasão. Educação à distância. Análise quantitativa de dados educacionais. Censo da educação superior.
Formulation and Evaluation of Finger Millet based Convenience Mixes
Authors: Sinha Rekha , Sharma Bindu 
Published: February 2025

Background: Finger millet is an inevitable traditional climate-smart crop of Jharkhand, which has the potential to address the problem of malnutrition on a sustainable basis. However, despite its nutritional and health potential, it is on the verge of extinction. The revival of finger millet in the daily diet of people requires diversification of the products suiting to the changing needs of the consumers. Rapid industrialization and urbanization and changes in the eating habits of Indian people led to a very high demand for convenience mix. Therefore, an attempt was made to develop a low-cost finger millet-based burfi and halwa mix and evaluate the nutritional quality of the mixes. Methods: Two types of burfi mix and halwa mix were developed by using ragi malt or ragi semolina, wheat and germinated green gram supplemented with milk powder, groundnut, etc. Developed products were subjected to sensory evaluation on a 9-point Hedonic scale and analyzed for proximate composition, calcium, iron, phosphorus, copper, zinc, and ß-carotene by standard methods. Result: All products were found acceptable. Both experimental burfi and halwa mixes were found superior in terms of protein, fiber, calcium, phosphorus, iron, copper and zinc.
Le laboratoire de biotechnologie des systèmes symbiotiques forestiers tropicaux de Nogent-sur-Marne
Authors: Rédacteur de la revue Bois et Forêts des Tropiques  
Published: February 2025

Le Laboratoire de Biotechnologie des Systèmes Symbiotiques Forestiers Tropicaux (BSSFT) de Nogent-sur-Marne a été créé principalement pour étudier la biologie des symbioses fixatrices d'azote chez diverses espèces ligneuses tropicales, en adoptant des méthodes à la fois microbiologiques (amélioration du micro-organisme symbiotique) et végétales (amélioration de la plante hôte). Trois types d'associations symbiotiques sont étudiés dans ce laboratoire : (a) symbioses actinomycorhiziennes, espèce modèle Casuarina equisetifolia ; b) Légumineuses ligneuses de la zone humide, espèce modèle Acacia mangium ; c) Légumineuses ligneuses de la zone sèche. Le personnel permanent du Laboratoire est composé de cinq chercheurs, auxquels s'ajoutent sept autres personnes qui préparent leur thèse. En outre, le BSSFT accueille des stagiaires français et étrangers de la CEE et des pays en voie de développement. Outre les serres et les chambres d'incubation pour micro-organismes et les cultures de tissus parfaitement réglées, le laboratoire du BSSFT est équipé d'un matériel classique de microbiologie, constitué principalement d'autoclaves, de microscopes (fluorescent, inversé), d'un chromatographe en phase gazeuse, de centrifugeuses, de hottes à flux laminaire, de deux types originaux de fermenteurs et d'un ultramicrotome. Deux des résultats obtenus à ce jour sont très encourageants. Le premier concerne l'inoculation de Casuarina equisetifolia avec du frankia : des tests sur le terrain ont montré que cette inoculation est la condition sine qua non pour l'établissement de cette espèce dans les dunes dépourvues d'azote. Le deuxième exemple concerne la possibilité d'augmenter la fixation d'azote des arbres par sélection clonale : cette procédure a permis de doubler la fixation d'azote de Casuarina equisetifolia en peu de temps. Le BSSFT développe actuellement une nouvelle procédure de conditionnement des inocula dans des matrices polymères.
Diabetes Mellitus Risk Screening In Keniten Village, East Java
Authors: Wiratmoko Heru , Purwaningsih Endang , Suwanto Agus Wiwit , Hartanto Agung Eko , Widya Indrawati Gandes , Purwaningsih Yustina , Mandasari Yuyun Putri 
Published: February 2025

Perubahan gaya hidup masyarakat dapat memicu timbulnya penyakit tidak menular salah satunya penyakit Diabetes Mellitus. Berdasarkan data dari WHO, pada tahun 2014, DM menempati peringkat kelima sebagai penyebab kematian utama di dunia. Jumlah kematian akibat DM diproyeksikan meningkat lebih dari 50% dalam sepuluh tahun mendatang. International Diabetic Federation melaporkan terdapat 4,6 juta kematian akibat DM setiap tahun dan lebih dari 10 juta penderita mengalami kelumpuhan dan komplikasi yang mengancam jiwa, seperti serangan jantung, stroke, gagal ginjal, kebutaan dan amputasi. Prevalensi penderita DM diperkirakan akan terus meningkat setiap tahunnya (IDF, 2014). Maka perlunya dilakukan suatu langkah untuk mengatasi masalah tersebut dengan melakukan screening, senam DM dan penyuluhan bagi masyarakat. Pengabdian masyarakat Kelurahan Kenitan dilakukan kepada 96 orang dengan hasil pemeriksaan Gula Darah menunjukkan yang menderita DM (GDA ≥ 200 mg/dl) sebanyak 3 orang ( 3,13%), sedangkan hasil Sreening dengan kuisioner Findrick resiko rendah 33 orang (34,38%), resiko sedikit meningkat 49 orang (51,04%), resiko sedang 12 orang (12,5%) dan resiko tinggi 2 orang (2,08%)
Indications of a Survival Benefit from Primary Tumor Treatment in Uveal Melanoma: Association Between initial AJCC Stage and Metastatic Survival
Authors: Yavuzyigitoglu Serdar , Sabazade Shiva , Gill Viktor , Brosens Erwin , Kiliç Emine , Stålhammar Gustav 
Published: February 2025

Abstract

In theory, a more advanced American Joint Committee on Cancer (AJCC) stage at the time of primary tumor diagnosis could correlate with shorter survival in metastatic uveal melanoma. However, this association has only been evaluated in relatively small cohorts. To address this, we investigated the prognostic relationship between AJCC stage and survival in a large cohort of patients who died from metastatic uveal melanoma. Among 1491 real-world patients, a higher AJCC stage at the time of primary tumor diagnosis was significantly associated with shorter survival. This association persisted even when the analysis was restricted to 350 patients already at stage IV, where a higher AJCC stage at primary tumor diagnosis continued to correlate with shorter survival (Log-rank test for trend, P< 0.001 for both comparisons). The relationship remained significant in multivariate Cox regression models, which included patient age as a covariate and the number of hepatic metastases upon detection of metastatic disease as a time-varying covariate, as well as in a Markov multi-state model. These findings suggest that primary tumor treatment, by preventing the tumor from advancing to a higher AJCC stage, may confer a survival benefit by potentially reducing the aggressiveness and growth rate of subsequent metastases.
5 V-Class 35.3 mAh cm-2 All-Solid-State Li Batteries
Authors: Jung Yoon Seok , Son Jun Pyo , Park Juhyoun , Kim Hae-Yong , Kim Jae-Seung , Song Yong Bae , Kim Changhoon , Kim Donghyeok , Kim Jong Seok , Ko Sunho , Ahn Docheon , Kwon Gihan , Seo Dong-Hwa , Nam Kyung-Wan , Chae Keun Hwa , Du Yonghua , Wierzbicki Dominik 
Published: February 2025

Abstract

The advancement of battery technology has been impeded by the voltage constraints of electrolytes. Here, we present a high-energy all-solid-state battery (ASSB) design that achieves both a >5 V operation and an ultrahigh areal capacity of 35.3 mAh cm-2; these attributes were enabled by a new, highly conductive and ultrahigh voltage stable fluoride solid electrolyte (SE), LiCl–4Li2TiF6 (1.7 x 10-5 S cm-1 at 30 °C). This material provides over 100 times higher Li+ conductivity than Li2TiF6, attributable to the enlarged Li+ channels and increased Li+ concentration at the nanocrystallite interfaces, as proved by combined experimental and theoretical investigations. LiCl–4Li2TiF6 shields high-voltage spinel oxide cathodes, achieving excellent performance (e.g., 106 mAh g-1 at 2C and 30 °C with 75.2% retention after 500 cycles for LiNi0.5Mn1.5O4), sharply contrasting with the conventional LiNbO3 counterpart, which decomposes and fails to prevent detrimental interfacial degradation. The efficacy of LiCl–4Li2TiF6 is validated across various systems, including higher-voltage LiCoMnO4, cost-effective LiFe0.5Mn1.5O4, pouch-type LiNi0.5Mn1.5O4//Li ASSBs, operability down to 2.3 V with 258 mAh g-1, and 1.8 mm ultrathick electrodes. This newly proposed SE with over 5 V stability introduces a new design paradigm by revisiting the previously forbidden high-voltage cathodes for high-energy ASSBs.
Assessing the residual effects of the “defeated” tomato Mi-1.2 gene against a Meloidogyne enterolobii (guava race) population via comparative assays with contrasting near-isogenic lines
Authors: CUNHA Dwillian F. , PINTO Thávio J. B. , PINHEIRO Jadir B. , SILVA Giovani O. , RAFAEL Felipe S. , SANTOS Leandro A. , FONSECA Maria Esther N. , CARES Juvenil E. , BOITEUX Leonardo S. 
Published: February 2025

Abstract

Meloidogyne enterolobii represents a major threat to the global tomato (Solanum lycopersicum L.) production due to its ability to “break-down” the resistance conferred by the dominant Mi-1.2 gene. However, a subgroup of “defeated” resistance genes in various pathosystems exhibits residual effects characterized by an enduring interference in quantitative levels of disease expression induced by novel virulent pathogens. Thus far, residual effects of the “defeated” Mi-1.2 gene to M. enterolobii have not been properly investigated. Herein, two comparative assays using contrasting near-isogenic lines (NILs) for presence/absence of the Mi-1.2 locus were carried out using a guava race population of M. enterolobii. Seedlings of two pairs of contrasting NILs ‘Nemadoro’ (homozygous dominant; Mi-1.2/Mi-1.2) / ‘Rio Grande’ (homozygous recessive, mi-1.2/mi-1.2) and ‘Del Rey’ (Mi-1.2/Mi-1.2) / ‘Calipso’ (mi-1.2/mi-1.2) were inoculated with ≈ 2,000 M. enterolobii eggs. The homozygous dominant (Mi-1.2/Mi-1.2) NILs displayed values for the quantitative parameter NEGR (number of eggs + occasional J2 per gram of root tissue) similar or even superior to their corresponding recessive (mi-1.2/mi-1.2) NILs. A slight positive impact of the resistance gene in the reproduction factor (RF) value was observed only for one pair of contrasting NILs (‘Del Rey’ / ‘Calipso’), which was restricted to one bioassay. The employment of NILs in our bioassays allowed us to hypothesize that the Mi-1.2 gene, although extremely effective against populations of at least 13 Meloidogyne species, does not confer significant residual effects against M. enterolobii race from guava.
Deconstruction of a Memory Engram Reveals Distinct Ensembles Recruited at Learning
Authors: Pouget Clément , Morier Flora , Treiber Nadja , García Pablo Fernández , Mazza Nina , Zhang Run , Reeves Isaiah , Winston Stephen , Brimble Mark , Kim Christina , Vetere Gisella 
Published: February 2025

Abstract

How are associative memories formed? Which cells represent a memory, and when are they engaged? By visualizing and tagging cells based on their calcium influx with unparalleled temporal precision, we identified non-overlapping dorsal CA1 neuronal ensembles that are differentially active during associative fear memory acquisition. We dissected the acquisition experience into periods during which salient stimuli were presented or certain mouse behaviors occurred and found that cells associated with specific acquisition periods are sufficient alone to drive memory expression and contribute to fear engram formation. This study delineated the different identities of the cell ensembles active during learning, and revealed, for the first time, which ones form the core engram and are essential for memory formation and recall.
Climate change impacts on the accessibility of offshore structures
Authors: Bessonova Victoria , Casas-Prat Merce , Tapoglou Evdokia , York Katharine , Dorrell Robert 
Published: February 2025

Abstract

In the next 25 years an unprecedented number of new marine artificial structures,
over 75,000 offshore wind turbines alone, are planned to meet global net zero targets.
Structures are required to last for multiple decades in the hostile marine environment;
where the largest cost across their whole lifecycle is on operations and maintenance
dependent on accessibility in calm seas. However, the role of climate change
on accessibility, and thus operational cost, has not
been resolved. Here we provide the first study of future accessibility;
evaluated from global climate model driven wave modelling, using the high
emission scenario (RCP8.5). We found that climate change drives
significant regional variation in accessibility, with the northern hemisphere
benefiting from a 6% increase in operating windows whilst accessibility in parts of the
southern hemisphere is reduced by 6-9%. These findings will help offshore
developers and stakeholders incorporate adaptions to climate change as part of strategic planning practices.
Vision impairment is a risk factor for malnutrition in older long-term care residents.
Authors: Jyvakorpi Satu K , Soini Helena , Pitkala Kaisu H , Saarela Riitta KT , Muurinen Seija 
Published: February 2025

Abstract

Purpose To examine how vision is associated with nutritional status in long-term residentsMethods A random sample of 17 assisted-living facilities and nursing home including 2513 permanent long-term care residents (age ≥ 65 years) were examined by trained nurses about various health-related aspects. Nutritional status was assessed using the Mini Nutritional Assessment (MNA) long version and vision was estimated using a question from 15D-health-related quality of life questionnaire.Results 18% of the participants were characterised of having vision impairment. Vision impairment was an independent predictor of residents’ malnutrition (OR 1.62, 95% [1.22, 2.15], p < .001). Chewing problems (OR 2.78, 95% [2.18, 3.55], p < .001) and CDR memory item (OR 2.20, 95% [1.68, 2.87], p < 0.001) were also associated with malnutrition.Conclusion Vision impairment was associated with malnutrition, problems with oral health and poorer cognition, thus vision impairment should be considered as a risk factor for malnutrition in this vulnerable population.
A novel dominant RPE65-related retinopathy is caused by p.(E519K), a founder variant of Flemish origin
Authors: Vooren Eline Van , Broeck Filip Van den , Mahieu Quinten , Geens Eline , Heetvelde Mattias Van , De Bruyne Marieke , de Sompele Stijn Van , Uppal Sheetal , Poliakov Eugenia , Dhaenens Claire-Marie , Gregory-Evans Cheryl Y. , Hoefsloot Lies , Gonzalez Adriana Iglesias , Kohl Susanne , Zuleger Theresia , Demaret Tanguy ,   Dominant RPE65-E519K Consortium, Tuupanen Sari , Ruys Joke , Os Luc Van , Platteau Elise , Jacob Julie , Vermeer Sascha , Postelmans Laurence , Dahan Karin , Maystadt Isabelle , Rasquin Florence , Thiadens Alberta A.H.J. , Stephenson Kirk A.J. , Sheri Narin , Smirnov Vasily , MacDonald Ian M. , Gregory-Evans Kevin , Redmond T. Michael , De Zaeytijd Julie , Leroy Bart P. , Bauwens Miriam , De Baere Elfride 
Published: February 2025

Abstract

Background | Recessive RPE65-retinopathy is an inherited retinal disease (IRD) that is a well-known target for gene therapy. Dominant RPE65-retinopathy, however, due to the Irish founder variant p.(D477G), is very rare. Here, we present the discovery of a novel dominant RPE65-retinopathy caused by ultrarare variant c.1555G>A, p.(Glu519Lys), hereafter named p.(E519K).
Methods | In addition to genome (n=3), exome (n=28), or targeted sequencing (index: n=14; segregation: n=30) to identify the p.(E519K) variant, patients underwent extensive ophthalmological examinations. Haplotype phasing was based on long-read genome sequencing data in four individuals, combined with microsatellite analysis of six markers in all index cases. The p.(E519K) variant was functionally assessed using an enzymatic RPE65 assay, western blotting, co-immunoprecipitation, cellular thermal shift assay (CETSA), minigene assays and protein modelling (AlphaFold).
Results | Using genome, exome, or targeted sequencing in Belgian IRD cases (discovery cohort, n=2,873) and interrogating genomic IRD databases from France, the Netherlands, Germany, United Kingdom, Scotland, Ireland, and Canada (replication cohort, n=18,798) we identified 83 monoallelic p.(E519K)-IRD cases of Flemish ancestry. Long-read sequencing-based haplotyping revealed a shared region of 464 kb, confirming a founder effect. p.(E519K) affects a highly conserved amino acid and lowers RPE65 enzymatic activity to ~56%, in line with reduced protein expression. While no increased interaction with wild type RPE65 or aberrant splicing could be demonstrated in vitro, protein modelling and CETSA supports a shift in protein stability. Segregation analysis revealed dominant inheritance with complete penetrance and phenotypic variability, hallmarked by a characteristic late-onset macula-predominant IRD with two main subtypes. The milder phenotype is characterized by subtle, diffuse mottling of the posterior pole, while the more severe phenotype manifests as a macular pattern dystrophy with chorioretinal atrophy as a hallmark.
Conclusions | The discovery of a dominant RPE65-IRD due to the ultrarare Flemish founder variant p.(E519K) reduces the diagnostic gap in dominant IRD and highlights a novel target for therapy.