bluuebunny/crossref_metadata_2025_split huggingface dataset:
Unveiling the life of archaea in sediments: Diversity, metabolic potentials, and ecological roles
Authors: Zou Dayu , Qi Yanling , Zhou Jinjie , Liu Yang , Li Meng 
Published: January 2025

AbstractThe domain Archaea was initially characterized as extremophiles upon its proposal. Recent significant discoveries have redrawn our views of archaeal biology, encompassing the identification of mesophilic archaeal groups, the expansion of archaeal diversity and metabolic capabilities, and the elucidation of evolutionary relationships among archaea, bacteria, and eukaryotes. Archaea are ubiquitous and constitute a substantial fraction of the microbial biomass within sediments. Therefore, comprehending their ecological roles is paramount for understanding their contributions to global geochemical cycles. In this review, we summarize the diversity of archaea across various sediment ecosystems, from terrestrial inland to deep‐sea environments, utilizing representative genomes supported by the Genome Taxonomy Database, which encompasses habitats such as hot springs, salt lakes, freshwater lakes, rivers, mangroves, estuaries, coastal regions, seafloor sediments, cold seeps, and hydrothermal vents. Furthermore, we integrate analyses of representative genomes with recent studies to highlight the metabolic potentials, novel enzymatic functions, and significant discoveries related to the carbon, nitrogen, and sulfur cycles across different archaeal lineages. Finally, we discuss recent research hotspots and achievements in archaeal studies, while projecting future exploration directions. The expanding diversity and metabolic capacities of archaea have broadened our perspective on the tree of life and underscored their critical impacts on ecosystems.
DISPLAY REQUIREMENTS of the INTEGRATED MANAGEMENT INFORMATION SYSTEMS ‐ 1968‐1970
Authors: James Peter , Dittberner Donald L. 
Published: January 2025

ABSTRACTBy 1970, with advances in control and reproducibility of displayed materials, the advent of reusable films, and overall cost reductions due to increased production levels, nearly every large integrated management information system will have many displays associated with it. Capabilities such as high resolution character formation adequate to obtain lithographic quality reports open the door to many new commercial uses for displays.Principal categories of use include simulation, information storage and retrieval, browsing, message composition, high quality recording, and industrial education. Mixing of stored graphic (microfilm and video) information with computer generated data will become the rule rather than the exception. This use will be slower in obtaining general acceptance than other technical advances such as memory technology and improved data collection devices. Nonetheless, from the integrated management information system viewpoint, displays offer one of the few tools which will be helpful directly to the highest level of management, and a tool that must be exploited in order to obtain the full benefits of better accounting and control systems.Fifty‐eight display applications are identified by specialization or industry and categorized into seven classes of display capability. Price performance forecasts are given for each of the seven classes of capabilities for the years 1963‐1965 and 1968‐1970.
Information Display in a Vehicular Traffic Control System Of the Post‐1970 Era
Authors: Bairdain Edith 
Published: January 2025

AbstractThis paper proposes the application of systems analysis and design techniques developed in space and military systems technology to the problem of national highway vehicular traffic control. A control system, comprised of computer and electronic peripheral equipment, information display equipment, highway traffic enforcement personnel and regulatory procedures is described, with emphasis on design considerations that must govern the information display components of such system. A Vehicular Traffic Control System would be designed to control the overwhelming increase of vehicular traffic over the nationwide system of highways projected into the next few decades. Information display in such a system will represent perhaps the most widespread use of electronic information display technology in the post‐1970 era.
Hydrocortisone Attenuates the Development of Malformations of the Polymicrogyria Spectrum
Authors: Savoldi Laura Maria Borges , Heringer Luiza dos Santos , Carneiro Milena Batista , Martinez Ana Maria Blanco , Mendonça Henrique Rocha 
Published: January 2025

ABSTRACTMost of the malformations of the polymicrogyria spectrum are caused by destructive lesions of the neocortex during the third trimester of pregnancy, triggered by hypoxic–ischemic, hemorrhagic or infectious events, with neuroinflammation as a common pathophysiological mechanism. Our study investigated hydrocortisone treatment in attenuating inflammation, malformations development and seizures predisposition in mice subjected to neonatal transcranial freeze lesion. Our results show attenuation of malformation and predisposition to febrile seizures, with concomitant reduction of macrophages/microglia after neonatal freeze lesion, polarizing them towards an anti‐inflammatory profile. Thus, we have identified a promising treatment to minimize the development of cortical developmental malformations.
Optimized Transfer Learning With Hybrid Feature Extraction for Uterine Tissue Classification Using Histopathological Images
Authors: Patil Veena I. , Patil Shobha R. 
Published: January 2025

ABSTRACTEndometrial cancer, termed uterine cancer, seriously affects female reproductive organs, and the analysis of histopathological images formed a golden standard for diagnosing this cancer. Sometimes, early detection of this disease is difficult because of the limited capability of modeling complicated relationships among histopathological images and their interpretations. Moreover, many previous methods do not effectively handle the cell appearance variations. Hence, this study develops a novel classification technique called transfer learning convolution neural network with artificial bald eagle optimization (TL‐CNN with ABEO) for the classification of uterine tissue. Here, preprocessing is done by the median filter, followed by image enhancement by the multiple identities representation network (MIRNet). Moreover, pelican crow search optimization (PCSO) is used for adapting weights in MIRNet, where PCSO is generated by combining the crow search algorithm (CSA) and pelican optimization algorithm (POA). Then, segmentation quality assessment (SQA) helps in tissue segmentation, and deep convolutional neural network (DCNN) helps in parameter selection that is trained by fractional PCSO (FPCSO). Furthermore, feature extraction is done and, finally, cell classification is done by TL with CNN, which is trained by the proposed ABEO algorithm. Here, ABEO is newly developed by the integration of the bald eagle search (BES) algorithm and artificial hummingbird algorithm (AHA). Furthermore, ABEO + TL‐CNN achieved a high accuracy of 89.59%, a sensitivity of 90.25%, and a specificity of 89.89% by utilizing the cancer image archive dataset.
Early differential diagnosis of cystic biliary atresia and choledochal cyst in the fetus: A multicenter retrospective study
Authors: Guan Xisi , Zhong Wei , Ouyang Yu , Wang Zhe , Yan Bin , Hou Longlong , Wang Junjie , Wu Yue , Huang Lin , Liang Xiaoxiong , He Qiuming , Xiao Shangjie , Yu Jiakang 
Published: January 2025

AbstractBackground/PurposeFetal hilar cyst is primarily diagnosed as two diseases after birth, cystic biliary atresia (CBA) and choledochal cyst (CC). The aim of our study was to explore more reliable indicators in early differential diagnosis of these cysts.MethodsWe recruited a total of 50 cases with a prenatal diagnosis of hepatic cyst at three centers, and patients were divided into a CBA group (n = 16) and CC group (n = 34) according to postnatal intraoperative diagnosis. Patient features, maximal cyst diameter as measured by prenatal and early postnatal ultrasonography were analyzed and compared between the two groups, as was the effect of cyst size in predicting CBA.ResultsThe maximal cyst diameters in the last prenatal ultrasound (LPU) measurement and initial postnatal ultrasound (IPU) in the CBA group were significantly smaller than in the CC group, as was the difference between the IPU and the first prenatal ultrasound (FPU) (i.e., IPU−FPU) in the CBA group relative to the CC group. The IPU–FPU difference showed the best diagnostic performance as a single parameter (AUC, 0.9806), with a sensitivity and specificity of 100% and 90.3%, respectively, and a cutoff value of 7.5 mm.ConclusionUltrasonographic measurement of the maximal cyst diameter can assist in early (within 1 week after birth) identification of CBA. An IPU‐FPU <7.5 mm suggested a higher possibility of a postnatal diagnosis of CBA.
Deciphering the Relationship Between Moisture Flux and Monsoon Extreme Rainfall Over the West Coast of India
Authors: Maria Tesna , Kottayil Ajil , Xavier Prince , John Viju O. 
Published: January 2025

ABSTRACTThe west coast of India has recently been experiencing torrential monsoon rains, a trend that studies indicate is likely to continue under future warming scenarios. This study investigates the link between moisture flux and extreme rainfall over the west coast, using observational and reanalysis datasets for the monsoon seasons (June to September) from 1990 to 2023. The analysis shows that, over the Indian subcontinent, rainfall along the west coast is primarily influenced by large‐scale moisture flux from the Arabian Sea. By decomposing the vertically integrated moisture flux into dynamic and thermodynamic components, this study observes that the thermodynamic component of moisture flux exhibits an increasing trend over the southwest coast, while this increasing trend is more prominent for the dynamic component over the northwest coast. Extreme rainfall over the southwest coast is increasing at a rate of 0.23 mm per season, attributed primarily to the increase in the thermodynamic component of moisture flux. It is observed that the rate of sea surface temperature (SST) increase over the Arabian Sea is faster than over the Bay of Bengal, with the average SST over the southeast Arabian Sea exceeding 28°C in recent years. Observations indicate that warming over the southeast Arabian Sea is strongly coupled with moisture accumulation observed over the southwest coast. This study provides strong evidence of a link between moisture transport, extreme rainfall and SST, identifying the southwest coast as a region vulnerable to climate change. Over the northwest coast, the incidence of extreme rainfall is associated with the strengthening of dynamic processes, and the mean monsoon rainfall in this region is increasing in alignment with the rising dynamic component of moisture flux.
Gut Microbiome and Metabolome Changes in Chronic Low Back Pain Patients With Vertebral Bone Marrow Lesions
Authors: Li Wentian , Tu Ji , Zheng Jinjian , Das Abhirup , Yan Qi , Jiang Xiaotao , Ding Wenyuan , Bai Xupeng , Lai Kaitao , Yang Sidong , Yang Cao , Zou Jun , Diwan Ashish D. , Zheng Zhaomin 
Published: January 2025

ABSTRACTBackgroundChronic low back pain (LBP) is a significant global health concern, often linked to vertebral bone marrow lesions (BML), particularly fatty replacement (FR). This study aims to explore the relationship between the gut microbiome, serum metabolome, and FR in chronic LBP patients.MethodsSerum metabolomic profiling and gut microbiome analysis were conducted in chronic LBP patients with and without FR (LBP + FR, n = 40; LBP, n = 40) and Healthy Controls (HC, n = 31). The study investigates alterations in branched‐chain amino acids (BCAAs) levels and identifies key microbial species associated with BCAA metabolism. In vitro experiments elucidate the role of BCAAs in adipogenesis of bone marrow mesenchymal stem cells (BM‐MSCs) via the SIRT4 pathway.ResultsChronic LBP patients with FR exhibit depleted BCAA levels in their serum metabolome, along with alterations in the gut microbiome. Specific microbial species, including Ruminococcus gnavus, Roseburia hominis, and Lachnospiraceae bacterium 8 1 57FAA, are identified as influential in BCAA metabolism and BM‐MSCs metabolism. In vitro experiments demonstrate the ability of BCAAs to induce BM‐MSCs adipogenesis through SIRT4 pathway activation.ConclusionThis study sheds light on the intricate relationship between the disturbed gut ecosystem, serum metabolites, and FR in chronic LBP. Dysbiosis in the gut microbiome may contribute to altered BCAA degradation, subsequently promoting BM‐MSCs adipogenesis and FR. Understanding these interactions provides insights for targeted therapeutic strategies to mitigate chronic LBP associated with FR by restoring gut microbial balance and modulating serum metabolite profiles.
Solventless Dual‐Cure Liquid Resins Via Circular Use of Phthalic Anhydride for Recyclable Composite Applications
Authors: Musgrave Grant M. , Reese Caleb J. , Kirk Tyler A. , Wang Chen 
Published: January 2025

AbstractFiber‐reinforced composites (FRCs) possess a remarkable strength‐to‐weight ratio, making them ideal light‐weighing alternative materials of metals used in automotive, aerospace, and outdoor equipment applications, but their recycling is challenging. Chemically recyclable thermoset polymers can enable fiber recovery and reuse; however, challenges remain in the separation and purification of depolymerized small molecules for efficient polymer recycling. To this end, a series of liquid resins for chemically recyclable polymer networks is designed based on phthalic anhydride, a widely produced and inexpensive chemical. The straightforward sublimation of phthalic anhydride is leveraged to enable a simple and efficient separation process for polymer recycling. To liquefy phthalic anhydride, five mono‐acryloyl‐phthalates are synthesized to obtain stable liquid resins together with phthalic diglycidyl ester. These liquid resins undergo dual‐cure reactions that comprise photopolymerization of acrylate and, subsequently, heat‐mediated epoxy‐acid polymerization reactions. These liquid resins exhibit moderate viscosities (2600–6400 cP @ 22 °C), fast curing, and robust thermomechanical properties (Tgs from 71 to 116 °C). It is demonstrated that hydrolysis of the dual‐cured polymers completes within 2 h at 80 °C, and direct sublimation produces phthalic anhydride with 82% yield. This resin system is expected to provide a cost‐competitive, highly efficient platform for recyclable FRCs.
Robust Sampled‐Data Synchronization of Memristor Inertial Competitive Neural Networks With Two Delay Components
Authors: Subhashri A. R. , Radhika T. 
Published: January 2025

ABSTRACTThe current study addresses the issue of synchronization in competitive neural networks that are based on memristors and involve an inertial term, parameter uncertainty, and two delay components using sampled‐data control. To achieve synchronization, appropriate Lyapunov‐Krasovskii functionals (LKFs) are constructed, which include double and triple integral terms that capture the information of time delay cross terms. Some sufficient synchronization conditions are derived in terms of linear matrix inequalities (LMIs) using an improved reciprocally convex combination inequality and generalized free weighting matrices inequality. The effectiveness of the proposed findings is highlighted through an illustrative example, validating the robustness and reliability of the developed synchronization approach.
Exploring the feasibility of millimeter‐wave sensors for non‐invasive respiratory motion visualization in diagnostic imaging and therapy
Authors: Kosaka Hiroyuki , Kubo Kazuki , Matsumoto Kenji , Nakamura Yasunori , Monzen Hajime 
Published: January 2025

AbstractBackgroundManagement of respiratory motion during radiation therapy is essential for accurate dose delivery and minimizing the risk to organs. In diagnostic imaging, respiratory monitoring is required for confirmation of breath‐hold and four‐dimensional computed tomography (CT) reconstruction. Although respiratory monitoring systems are widely used in radiation therapy, they are not often used for diagnostic imaging, where they could improve image quality.PurposeThe purpose of this study was to use a millimeter‐wave sensor (MWS) to noninvasively visualize respiratory motion, confirm breath‐holding, and explore the potential for clinical implementation of an MWS in diagnostic x‐ray imaging, CT, and radiation therapy.MethodsA 24 GHz microMWS was used in this study. The MWS directionality was determined using a radio‐wave dark‐box system. An antenna directionality test evaluated the effective azimuthal and elevational beamwidths. Respiratory waveforms were detected by optimizing the fast Fourier transform threshold and the cutoff frequencies of the bandpass filter. To confirm the reproducibility of the MWS, the detected waveforms were compared with those of a respiratory motion phantom (QUASAR), the amplitude of motion of which could be controlled. The time from valley to peak of the waveforms obtained by normalized MWS and the QUASAR were compared. The MWS was used to acquire respiratory waveforms of 20 healthy volunteers (including an infant and a child) in geometries adopted during chest CT (supine position; anteroposterior view; source‐to‐surface distance, 400 mm) and chest x‐ray imaging (standing position; posteroanterior view; source‐to‐surface distance, 1800 mm).ResultsThe effective azimuthal and elevational beamwidths of the MWS were approximately ± 20° and ± 40°, respectively. By optimizing the acquisition parameters (high‐sensitivity setting; with noise cancelling; frequency range, 10–20 min−1), the waveforms detected using the MWS approximately matched those of the respiratory motion phantom at all amplitudes. The MWS was also used to confirm breath‐holding in 18 volunteers in both supine (anteroposterior view) and standing (posteroanterior view) positions. In addition, for an infant and a child who were unable to follow the instruction to stop breathing, a visual count of their inhalations matched the number of respiratory cycles measured using the MWS.ConclusionThe 24 GHz MWS successfully monitored respiratory motion and breath‐holding during radiographic and CT imaging. With effective directionality and stability, this system holds promise for clinical management of respiratory motion during diagnostic imaging and radiation therapy.
Development of a CT radiomics prognostic model for post renal tumor resection overall survival based on transformer enhanced K‐means clustering
Authors: Wang Yiren , Li Yunfei , Chen Shouying , Wen Zhongjian , Hu Yiheng , Zhang Huaiwen , Zhou Ping , Pang Haowen 
Published: January 2025

AbstractBackgroundKidney tumors, common in the urinary system, have widely varying survival rates post‐surgery. Current prognostic methods rely on invasive biopsies, highlighting the need for non‐invasive, accurate prediction models to assist in clinical decision‐making.PurposeThis study aimed to construct a K‐means clustering algorithm enhanced by Transformer‐based feature transformation to predict the overall survival rate of patients after kidney tumor resection and provide an interpretability analysis of the model to assist in clinical decision‐making.MethodsThis study was based on a publicly available C4KC‐KiTS‐2019 dataset from the TCIA database, including preoperative computed tomography (CT) images and survival time data of 210 patients. Initially, the radiomics features of the kidney tumor area were extracted using the 3D slicer software. Feature selection was then conducted using ICC, mRMR algorithms, and LASSO regression to calculate radiomics scores. Subsequently, the selected features were input into a pre‐trained Transformer model for feature transformation to obtain a higher‐dimensional feature set. Then, K‐means clustering was performed using this feature set, and the model was evaluated using receiver operating characteristic (ROC) and Kaplan–Meier curves. Finally, the SHAP interpretability algorithm was used for the feature importance analysis of the K‐means clustering results.ResultsEleven important features were selected from 851 radiomics features. The K‐means clustering model after Transformer feature transformation showed AUCs of 0.889, 0.841, and 0.926 for predicting 1‐, 3‐, and 5‐year overall survival rates, respectively, thereby outperforming both the K‐means model with original feature inputs and the radiomics score method. A clustering analysis revealed survival prognosis differences among different patient groups, and a SHAP analysis provided insights into the features that had the most significant impacts on the model predictions.ConclusionsThe K‐means clustering algorithm enhanced by the Transformer feature transformation proposed in this study demonstrates promising accuracy and interpretability in predicting the overall survival rate after kidney tumor resection. This method provides a valuable tool for clinical decision‐making and contributes to improved management and treatment strategies for patients with kidney tumors.
Hormonal Regulation of Urokinase‐ and Tissue‐Type Plasminogen Activator in Mouse Sertoli Cells
Authors: Carosi Sara , Innocenti Federica , Monaco Lucia , Laurenzi Gaia , Saracino Rossana , Canipari Rita , Vicini Elena 
Published: January 2025

ABSTRACTA role for the plasminogen activator (PA) system has been postulated in mammalian gonads, considering the complex process of morphogenesis these organs undergo during their development. Our results show that mouse Sertoli cells under basal conditions produce both types of PA, tissue‐type PA (tPA) and urokinase‐type PA (uPA), and hormonal treatments increase the production of both enzymes. The increased enzyme secretion does not correlate with a parallel increase in their mRNAs. However, the proteolytic activity results from a balance between enzyme activity and inhibitors. Hormonal stimulation decreased the expression of the inhibitor PAI‐1, suggesting that the increase in proteolytic activity might depend on the decreased production of PAI‐1.The expression of the two enzymes and their inhibitor depends on the seminiferous epithelium stage. We observed higher uPA mRNA levels at stages VII‐VIII and IX‐XII, tPA peaks at stages VII‐VIII, and PAI‐1 mRNA levels decreased at stages VII‐VIII and IX‐XII.The testes from mice lacking the uPA gene (uPA−/−) presented statistically smaller sizes and weights. Histological analysis of uPA−/−animals showed tubular morphology defects and atypical residual bodies (RB), suggesting a defect in Sertoli cell phagocytosis. Moreover, we show lower sperm concentration and motility in uPA−/− mice. These data suggested an effective deficiency of testicular development in the absence of uPA.