bluuebunny/crossref_metadata_2025_split huggingface dataset:
Phase shift control of dual active bridge DC‐DC converter based on feedforward compensation and transient optimization strategy
Authors: Luo Lei , Liu Yitao , Yin Jian , YunWang  , Pan Xuewei 
Published: February 2024

SummaryIn the context of the dual active bridge (DAB) bidirectional DC‐DC converter using the traditional dual‐phase‐shift (DPS) control method, a transient DC bias occurs during power co‐direction and commutation conversion. This bias negatively impacts the converter's transient performance and can lead to harsh effects, such as hard switching problems, resulting in power loss and excessive current stress. In a closed‐loop control system, poor transient response may destroy the stability of the converter. In this paper, the transient‐optimized‐dual‐phase‐shift (TODPS) control strategy is proposed to eliminate the transient DC bias and to maintain soft switching during transient states. It reduces power loss, eliminates excessive current stress, and allows for smooth transitions between single‐phase‐shift (SPS) and DPS control strategies without introducing DC bias. A closed‐loop control system based on TODPS control is established with feed‐forward compensation to adjust the primary‐side current and modify transmission power. This adjustment enhances the transient performance of the DAB converter. The proposed strategy is versatile and applicable to various power conversion scenarios involving DAB converters. It enables quick switching of the magnitude and direction of the primary‐side current during transient states, resulting in a smooth transient effect without noticeable overshoot or oscillation. The experiment results verify the effectiveness of the proposed transient optimization strategy.
Variation in the contribution of macroinvertebrates to wood decomposition as it progresses
Authors: Taylor Melanie K. , Ulyshen Michael D. , Horn Scott , Poole Emilee M. , Callaham Mac A. 
Published: February 2024

AbstractAlthough necromass decay rates are limited by the slowest portions to decompose, most decomposition studies examine only the earliest stage of decay. As such, these studies run the risk of yielding misleading results regarding the relative contributions of different decomposers. For example, the contributions of macroinvertebrates to wood decomposition remain mostly unknown beyond the first 50% of mass lost, despite drastic changes in substrate conditions over time. We sought to clarify how the macroinvertebrate contribution to decay changes over the course of wood decomposition in the Southeastern United States—a region with a long history of wood decomposition research. To this end, we (1) compiled data from published studies comparing wood decay with and without macroinvertebrates; and (2) conducted a field study assessing wood mass loss, with and without macroinvertebrate access, at three sites across the region over four years. With these combined data, we analyzed macroinvertebrate contribution as decay progressed, revealing a quadratic relationship, wherein macroinvertebrate contribution increased early in decomposition and then began to decline as decay progressed. Strong local site effects, particularly the abundance and activity of termites, determine the time required for wood to reach this point of mass loss.
Association of global longitudinal strain by feature tracking cardiac magnetic resonance imaging with adverse outcomes among community‐dwelling adults without cardiovascular disease: The Dallas Heart Study
Authors: Subramanian Vinayak , Keshvani Neil , Segar Matthew W. , Kondamudi Nitin J. , Chandra Alvin , Maddineni Bhumika , Matulevicius Susan A. , Michos Erin D. , Lima Joao A.C. , Berry Jarett D. , Pandey Ambarish 
Published: February 2024

AimLeft ventricular (LV) global longitudinal strain (GLS) may detect subtle abnormalities in myocardial contractility among individuals with normal LV ejection fraction (LVEF). However, the prognostic implications of GLS among healthy, community‐dwelling adults is not well‐established.Methods and resultsOverall, 2234 community‐dwelling adults (56% women, 47% Black) with LVEF ≥50% without a history of cardiovascular disease (CVD) from the Dallas Heart Study who underwent cardiac magnetic resonance (CMR) with GLS assessed by feature tracking CMR (FT‐CMR) were included. The association of GLS with the risk of incident major adverse cardiovascular events (MACE; composite of incident myocardial infarction, incident heart failure [HF], hospitalization for atrial fibrillation, coronary revascularization, and all‐cause death), and incident HF or death were assessed with adjusted Cox proportional hazards models. A total of 309 participants (13.8%) had MACE during a median follow‐up duration of 17 years. Participants with the worst GLS (Q4) were more likely male and of the Black race with a history of tobacco use and diabetes with lower LVEF, higher LV end‐diastolic volume, and higher LV mass index. Cumulative incidence of MACE was higher among participants with worse (Q4 vs. Q1) GLS (20.4% vs. 9.0%). In multivariable‐adjusted Cox models that included clinical characteristics, cardiac biomarkers and baseline LVEF, worse GLS (Q4 vs. Q1) was associated with a significantly higher risk of MACE (hazard ratio [HR] 1.55, 95% confidence interval [CI] 1.07–2.24, p = 0.02) and incident HF or death (HR 1.57, 95% CI 1.03–2.38, p = 0.04).ConclusionsImpaired LV GLS assessed by FT‐CMR among adults free of cardiovascular disease is associated with a higher risk of incident MACE and incident HF or death independent of cardiovascular risk factors, cardiac biomarkers and LVEF.
A Palladium‐Catalyzed Regioselective [3+2] Annulation Strategy to 1,2,3‐Oxathiazolidine‐2‐oxides
Authors: Liang Qian , Bu Ganggang , Jiao Hongjian , Gao Bing 
Published: February 2024

AbstractA palladium‐catalyzed [3+2] annulation reaction of N‐sulfinylanilines with vinylethylene carbonates and vinyl epoxides is developed. It affords 1,2,3‐oxathiazolidine‐2‐oxides under mild reaction conditions through allylic palladium intermediates. The versatile synthetic utility of 1,2,3‐oxathiazolidine‐2‐oxides in preparing sulfoxides, β‐amino alcohols, and substituted amines has also been demonstrated.
Bispidine‐Based S,N‐Chiral Ligands for Palladium‐Catalyzed Asymmetric Arylation of Cyclic N‐Sulfonyl Ketimines
Authors: Li Gonglin , Wang Ruifeng , Ye Dong , Pu Maoping , Feng Xiaoming , Lin Lili 
Published: February 2024

AbstractDevelopment of new chiral ligands is essentially important in the field of asymmetric metal catalysis. Bispidines, steming from natural alkaloids, represent an intriguing yet underexplored class of chiral ligands. In this article, we developed a series of bispidine‐based chiral ligands with chirality locked in the side chain, and explore their properties by applying in the palladium‐catalyzed asymmetric addition of arylboric acids to cyclic N‐sulfonyl ketimines. A S,N‐bispidine ligand was found especially efficient, affording a series of chiral benzosultams with a quaternary chiral center in excellent yields with excellent ee values. Density functional theory (DFT) calculations and crystal structure of catalyst helped to propose a reasonable mechanism including a possible transition state model to explain the origin of stereoselectivity.
Electrokinetic transport of CTAB induces multiphasic behavior during capillary adsorption and desorption
Authors: Abrams Austin S. , Eden Alexander , Coy Bennett C. , Huber David E. , Pennathur Sumita 
Published: February 2024

AbstractCationic surfactant coatings (e.g., CTAB) are commonly used in CE to control EOF and thereby improve separation efficiencies. However, our understanding of surfactant adsorption and desorption dynamics under EOF conditions is limited. Here, we apply automated zeta potential analysis to study the adsorption and desorption kinetics of CTAB in a capillary under different transport conditions: diameter, length, voltage alternation pattern and frequency, and applied pressure. In contrast to other studies, we observe slower kinetics at distinct capillary wall zeta potential ranges. Within these ranges, which we call “stagnant regimes,” the EOF mobility significantly counteracts the electrophoretic (EP) mobility of CTA+ and hinders the net transport. By constructing a numerical model to compare with our experiments and recasting our experimental data in terms of the net CTA+ transport volume normalized by surface area, we reveal that the EP mobility of CTA+ and the capillary surface‐area‐to‐volume ratio dictate the zeta potential range and the duration of the stagnant regime and thereby govern the overall reaction kinetics. Our results indicate that further transport‐oriented studies can significantly aid in the understanding and design of electrokinetic systems utilizing CTAB and other charged surfactants.
Improving Sediment Toxicity Testing for Very Hydrophobic Chemicals: Part 1—Spiking, Equilibrating, and Exposure Quantification
Authors: Jonker Michiel T. O. , Diepens Noël J. 
Published: February 2024

Abstract
Sediment toxicity tests have applications in ecological risk and chemical safety assessments. Despite the many years of experience in testing and the availability of standard protocols, sediment toxicity testing remains challenging with very hydrophobic organic chemicals (VHOCs; i.e., chemicals with a log octanol/water partition coefficient of more than 6). The challenges primarily relate to the chemicals’ low aqueous solubilities and slow kinetics, due to which several experimental artifacts may occur. To investigate the potential artifacts, experiments were performed, focusing on spiking and equilibrating (aging) sediments, as well as exposure quantification with passive sampling. The results demonstrated that generally applied, Organisation for Economic Co-operation and Development–recommended spiking (coating) methods may lead to significant chemical losses and the formation of nondissolved, nonbioavailable VHOCs. Direct spiking appeared to be the most optimal, provided that intensive mixing was applied simultaneously. Passive dosing was tested as a novel way of spiking liquid VHOCs, but the approach proved unsuccessful. Intensive postspiking mixing during sediment equilibration for 1 to 2 weeks was shown to be essential for producing a homogeneous system, minimizing the presence of nondissolved chemical (crystals or nonaqueous phase liquids; NAPLs), and creating a stable toxicological response in subsequent toxicity tests. Finally, exposure quantification of VHOCs in sediments through passive sampling was found to be feasible with different polymers, although prolonged equilibration times may be required, and determining sampler/water partition coefficients can be extremely challenging. The results of additional experiments, focusing on toxicity test exposure duration, concentrations above which NAPLs will occur, and ways to distinguish actual toxicity from false-positive results, are presented in Part 2 of this publication series. Environ Toxicol Chem 2024;43:1717–1727. © 2024 The Authors. Environmental Toxicology and Chemistry published by Wiley Periodicals LLC on behalf of SETAC.
Culturally responsive evaluation teaching and learning in higher education: A higher calling
Authors: Hall Jori N. , Avent Cherie M. , Boyce Ayesha S. , Acheampong Kwame O. 
Published: February 2024

AbstractCulturally responsive evaluation (CRE) education has gained traction over the past 15 years, yet there is a dearth of literature on this topic. In response, we offer guidance on CRE education in higher education. Influenced by Stafford Hood, we engage CRE education as a social responsibility or a higher calling. Accordingly, in this article, we describe the importance of culturally responsive pedagogy (CRP) to fulfill our social responsibility in CRE education. We also highlight signature CRP used in our CRE courses, namely the incorporation of diverse practical field experiences and innovative instructional technology. We conclude with lessons learned.
Prognostic significances of systemic inflammatory response markers in patients with synchronous esophageal and head and neck cancers
Authors: Wang Chih‐Chun , Hsu Ming‐Hung , Lee Ching‐Tai , Chen Chi‐Jen , Hwang Tzer‐Zen , Wang Hsiu‐Po , Lin Jaw‐Town , Wang Wen‐Lun 
Published: February 2024

AbstractBackgroundPatients with head and neck squamous cell carcinoma (HNSCC) frequently develop synchronous esophageal cancer (ESCC), but there is a lack of clinical predictors. The neutrophil to lymphocyte (NLR), platelet to lymphocyte (PLR), and lymphocyte to monocyte ratios (LMRs), reflect the balance between pro‐cancer inflammation and anti‐cancer immune responses, but their role in HNSCC and synchronous cancer remain uncertain.MethodThe study consecutively enrolled a total of 717 patients with newly diagnosed HNSCC who received pre‐treatment esophageal endoscopic screening. The pretreatment NLR, LMR and PLRs were calculated and analyzed in comparison with the clinical factors.ResultsA total of 103 patients (14.4%) were found to have synchronous ESCCs, and were associated with a significantly lower absolute lymphocyte count (p < 0.001), higher NLRs (p = 0.044) and lower LMRs (p = 0.001), but not PLRs (p = 0.49). The ROC curve for the presence of synchronous ESCC verified the optimal cutoff value as 2.5 for NLRs and 4.0 for LMRs. Multivariable logistic regression revealed that a LMR <4 (OR 2.22; 95% CI 1.27–3.88, p = 0.005), alcohol consumption (OR 4.19; 95% CI 1.47–11.91, p = 0.007), tumor location over the pharynx (OR 1.68; 95% CI 1.07–2.64, p = 0.025), and low body mass index (OR 0.94; 95% CI 0.88–0.99, p = 0.039) were risk factors for developing synchronous ESCC. A low‐LMR was significantly associated with decreases in overall survival (p < 0.0001), in both synchronous and non‐synchronous groups. Multivariate analysis demonstrated that LMR <4 (HR 1.97; 95% CI 1.38–2.81, p < 0.001), a low‐BMI (HR 0.96; 95% CI 0.93–0.99, p = 0.044) and presence of synchronous ESCC (HR 1.56; 95% CI 1.10–2.22, p = 0.013) were independent prognostic factors for HNSCC patients.ConclusionIncorporation of LMR into other identified risk factors, such as alcohol consumption, tumor location over pharynx, and low‐BMI, may establish a more efficient screening program for esophageal exploration in HNSCC patients. The significances of LMR also suggest that anti‐cancer immunity may play a role in the filed cancerization to initiate multiple cancers, and the immunotherapy may have potentials for prevention or as an adjuvant treatment for synchronous SCC in the future.
The methodological and reporting quality of randomized controlled trials of tyrosine kinase inhibitors for advanced differentiated thyroid cancer: Meta‐research study
Authors: Dedivitis Rogério Aparecido , Castro Mario Augusto Ferrari de , Boni Alice Matos Dal , Alvares Ana Carolina Beltrão , Tresso Ana Júlia Piazentin , Oliveira Andrea Davedovicz de , Vieira Amanda Gonçalves da Silva Dourado , Mendes Fernanda Assaf , Rossi Giovana de Oliveira , Fava Giullia Neworal , Pouza Isabela Santos , Santana Izabelle Pimenta , Laino Julia Gibran , Lima Letícia Barbosa de , Martimbianco Ana Luiza Cabrera 
Published: February 2024

AbstractIntroductionClinical trials on tyrosine kinase inhibitors (TKI) treatment have shown an improvement in overall and progression‐free survival in patients with advanced differentiated thyroid cancer. However, it is necessary to evaluate these studies to assess methodological biases and inconsistencies that may impact the effects.ObjectiveTo map and assess the methodological quality of randomized clinical trials (RCTs) regarding randomization, allocation concealment, blinding, and selective reporting bias.MethodsRCTs assessing the efficacy and safety of TKI for the treatment of advanced differentiated thyroid cancer were included. The search was performed in the MEDLINE database. The included RCTs were assessed for the adequacy of the methodological steps, as recommended by the Cochrane Risk of Bias tool.ResultsNine studies were analyzed, of which 77.7% were classified as low risk of bias regarding selective reporting and 33.3% as high risk of reporting bias. The mean time between protocol registration and study publication was approximately 5.11 years. Moreover, 66.7% were classified as low risk of bias for randomization and allocation concealment, and 33.3% did not specify the randomization process and allocation concealment in a way that would allow the identification of occurrences of bias. Concerning blinding of participants and outcome assessors, 77.8% of the RCTs reported adequate blinding and were classified as having a low risk of bias, 11.1% had a high risk of bias, and 11.1% had insufficient information and were classified as having unclear risk of bias. Regarding the blinding of the outcome assessors, 33.3% did the blinding correctly, 11.1% did not blind, and 55.6% did not provide enough information.ConclusionOverall, the assessed RCTs were predominantly at low risk of bias. The critical evaluation of these studies is essential to have confidence in the treatment estimated effect that will support clinical decision‐making and provide information to preclude future clinical study flaws.
Experimental investigation of three fluid heat exchangers using roughness on the outer surface of a helical coil
Authors: Ahamad Sakeel , Verma Suresh Kant 
Published: February 2024

AbstractThe aim of this study is to utilize waste thermal energy from industries into useful heat for water and air heating. In this paper, the thermal modeling and performance of three fluid heat exchangers (TFHE) have been experimentally investigated. The TFHE considered here is an enhanced version of the double‐pipe heat exchanger. A novel TFHE having fin (1 mm thin copper wire of 10 mm pitch) acts as a roughness element, which is wrapped on the helical coil's outer surface for increasing heat transfer (HT) rate and the turbulence effect for normal water, and this outer surface finned helical coil is inserted between two concentric straight tubes. The innermost tube carries atmospheric air, the finned helical coil tube carries waste hot fluid while normal water flows in the inner annulus of the outermost tube. The coiled‐side Reynolds number is varied in the range of 7000–30,000, while the curvature ratio of 0.1315, pitch‐to‐inside diameter ratio of 2.88 and wire‐to‐tube diameter of the helical tube is kept constant. A counterflow arrangement has been made for experimentation. Nusselt number is calculated using the traditional Wilson plot method that is compared and validated with results available in the literature. The overall HT coefficient is found to increase by increasing the volume flow rate of fluids, while effectiveness decreases or increases depending on residence time and capacity ratio. The percentage increment in the Nusselt number, maximum friction factor, overall HT coefficient between waste hot fluid to normal water, effectiveness is found to be 21.10%–23.88%, 90.91%, 3.40%–29.45%, 3.40%–25.33%, respectively, for the coil side. TFHE is thus proposed for heating water and space simultaneously.
Systematic enhancement of microbial decontamination efficiency in bone graft processing by means of high hydrostatic pressure using Escherichia coli as a model organism
Authors: Loeffler Henrike , Waletzko‐Hellwig Janine , Fischer Ralf‐Joerg , Basen Mirko , Frank Marcus , Jonitz‐Heincke Anika , Bader Rainer , Klinder Annett 
Published: February 2024

AbstractTo obtain bone allografts that are safe for transplantation, several processing steps for decellularization and decontamination have to be applied. Currently available processing methods, although well‐established, may interfere with the biomechanical properties of the bone. High hydrostatic pressure (HHP) is known to devitalize tissues effectively while leaving the extracellular matrix intact. However, little is known about the inactivation of the contaminating microorganisms by HHP. This study aims to investigate the ability of high‐pressure decontamination and to establish a treatment protocol that is able to successfully inactivate microorganisms with the final goal to sterilize bone specimens. Using Escherichia coli (E. coli) as a model organism, HHP treatment parameters like temperature and duration, pressurization medium, and the number of treatment cycles were systematically adjusted to maximize the efficiency of inactivating logarithmic and stationary phase bacteria. Towards that we quantified colony‐forming units (cfu) after treatment and investigated morphological changes via Field Emission Scanning Electron Microscopy (FESEM). Additionally, we tested the decontamination efficiency of HHP in bovine cancellous bone blocks that were contaminated with bacteria. Finally, two further model organisms were evaluated, namely Pseudomonas fluorescens as a Gram‐negative microorganism and Micrococcus luteus as a Gram‐positive representative. A HHP protocol, using 350 MPa, was able to sterilize a suspension of stationary phase E. coli, leading to a logarithmic reduction factor (log RF) of at least −7.99 (±0.43). The decontamination of bone blocks was less successful, indicating a protective effect of the surrounding tissue. Sterilization of 100% of the samples was achieved when a protocol optimized in terms of treatment temperature, duration, pressurization medium, and number and/or interval of cycles, respectively, was applied to bone blocks artificially contaminated with a suspension containing 104 cfu/mL. Hence, we here successfully established protocols for inactivating Gram‐negative model microorganisms by HHP of up to 350 MPa, while pressure levels of 600 MPa were needed to inactivate the Gram‐positive model organism. Thus, this study provides a basis for further investigations on different pathogenic bacteria that could enable the use of HHP in the decontamination of bone grafts intended for transplantation.
SCARB1‐encoded circ _0029343 induces p73 splicing to promote growth and metastasis of hepatocellular carcinoma via miR‐486‐5p/SRSF3 axis
Authors: Zhu Shuo , Cao Shengya , Che Jinhui , Zhao Le , Su Zhan , Li Deqiang , Pei Ruifeng , Xu Lu , Ding Yiren , Zhou Wuyuan 
Published: February 2024

AbstractCircular RNAs (circRNAs) exhibit essential regulation in the malignant development of hepatocellular carcinoma (HCC). This study aims to investigate the physiological mechanisms of circ_0029343 encoded by scavenger receptor class B member 1 (SCARB1) involved in the growth and metastasis of HCC. Differentially expressed mRNAs in HCC were obtained, followed by the prediction of target genes of differentially expressed miRNAs and gene ontology and kyoto encyclopedia of genes and genomes analysis on the differentially expressed mRNAs. Moreover, the regulatory relationship between circRNAs encoded by SCARB1 and differentially expressed miRNAs was predicted. In vitro cell experiments were performed to verify the effects of circ_0029343, miR‐486‐5p, and SRSF3 on the malignant features of HCC cells using the gain‐ or loss‐of‐function experiments. Finally, the effects of circ_0029343 on the growth and metastasis of HCC cells in xenograft mouse models were also explored. It was found that miR‐486‐5p might interact with seven circRNAs encoded by SCARB1, and its possible downstream target gene was SRSF3. Moreover, SRSF3 was associated with the splicing of various RNA. circ_0029343 could sponge miR‐486‐5p to up‐regulate SRSF3 and activate PDGF‐PDGFRB (platelet‐derived growth factor and its receptor, receptor beta) signaling pathway by inducing p73 splicing, thus promoting the proliferation, migration, and invasion and inhibiting apoptosis of HCC cells. In vivo, animal experiments further confirmed that overexpression of circ_0029343 could promote the growth and metastasis of HCC cells in nude mice. circ_0029343 encoded by SCARB1 may induce p73 splicing and activate the PDGF‐PDGFRB signaling pathway through the miR‐486‐5p/SRSF3 axis, thus promoting the growth and metastasis of HCC cells.