bluuebunny/crossref_metadata_2025_split huggingface dataset:
consequences of long-term therapy with proton pump inhibitors
Authors: Drygała Zuzanna , Wyrwał Julia , Krasuska Martyna , Nowak Karolina , Olejarz Zuzanna , Zielińska Zuzanna , Słowik Magdalena , Nowak Karolina , Nieć Maria , Gierlach Katarzyna 
Published: January 2024

Introduction and purpose:
Proton pump inhibitors (PPIs) were first developed in the late 1970s and introduced to the market in 1989. They are one of the most commonly prescribed medications worldwide.
PPIs reduce gastric acid secretion in the stomach by inhibiting the hydrogen-potassium ATPase enzyme. They have revolutionized the treatment of diseases related to excessive stomach acid secretion. Among the drugs belonging to this class, we should mention omeprazole, esomeprazole, pantoprazole, lansoprazole, dexlansoprasole and rabeprazole.
A brief description of the state of knowledge:
Since the 1990s, the use of proton pump inhibitors has been consistently increasing. Doctors prescribe these drugs more frequently, in higher doses, and for longer durations, although such practices are only sometimes fully justified.
Although using them for a short period (less than eight weeks) is relatively safe, there is growing evidence of possible risks linked to their extended use. Many studies highlight the impact of long-term therapy on the development of tumors, deficiencies in micronutrients, the functioning of the skeletal, urinary, nervous, and cardiovascular systems, and the development of infections and diabetes.
Summary (conclusions):
Indeed, long-term therapy with proton pump inhibitors has an impact on the functioning of the body. Considering the increasing popularity of proton pump inhibitors and their expanding use, it is worth contemplating a more prudent prescription of these drugs by doctors.
It should also be noted that the majority of studies are based on prescription PPIs. Future researchers must also take over-the-counter (OTC) medications into account.
Unidirectional control of graphene plasmons by a semiconductor nanorod
Authors: Ma Zenghong , Wang Ride , Chen Zijian , Zhang Lian , Huang Ningning 
Published: January 2024

Controllable manipulation of propagating graphene plasmons (GPs) has important significance in the application of nanophotonic and optoelectronic technologies. In this paper, a simple graphene-semiconductor hybrid structure is proposed, in which unidirectional emission of propagating GPs can be achieved and controlled under circularly polarized light illumination. The impact of the distance between the nanorod and graphene and the radius of the nanorod on the excitation efficiency of GPs, as well as the impact on the unidirectional ratio are theoretically calculated in detail. The results show that considering both the unidirectional ratio and the excitation efficiency of GPs, the radius of the nanorod can be selected between 15 and 50 nm. It is also found that the maximum unidirectional ratio η of GPs does not depend on the different distances between the nanorod and graphene. This study not only provides optimized parameters for further experimental implementation, but also offers theoretical support for nanoscale information transmission and processing.
Large-scale error-tolerant programmable interferometer fabricated by femtosecond laser writing
Authors: Kondratyev Ilya , Ivanova Veronika , Fldzhyan Suren , Argenchiev Artem , Kostyuchenko Nikita , Zhuravitskii Sergey , Skryabin Nikolay , Dyakonov Ivan , Saygin Mikhail , Straupe Stanislav , Korneev Alexander , Kulik Sergei 
Published: January 2024

We introduce a programmable eight-port interferometer with the recently proposed error-tolerant architecture capable of performing a broad class of transformations. The interferometer has been fabricated with femtosecond laser writing, and it is the largest programmable interferometer of this kind to date. We have demonstrated its advantageous error tolerance by showing an operation in a broad wavelength range from 920 to 980 nm, which is particularly relevant for quantum photonics due to efficient photon sources existing in this wavelength range. Our work highlights the importance of developing novel architectures of programmable photonics for information processing.
Memoria inmunológica y reinfección por SARS-CoV-2/COVID-19
Authors: Forero Ladino Angélica Maria , Rivadeneira Santacruz Paola , Ospina Delgado Ana Maria , Rojas Hernandez Juan Pablo 
Published: January 2024

Antecedentes: El síndrome respiratorio agudo severo por Coronavirus 2 (SARS-CoV-2), es un tipo de coronavirus causante de la enfermedad por coronavirus (COVID-19), el cual se ha convertido en un importante problema para la salud pública mundial por la pandemia desencadenada y su alta transmisibilidad y mortalidad. Desde el inicio de la pandemia por SARS-CoV-2/COVID-19, se ha generado múltiples interrogantes como la producción de memoria inmunológica y aparición de casos de reinfección por el mismo virus.
Objetivo: Realizar una revisión acerca de las características microbiológicas, clínicas, memoria inmunológica y reinfección por SARS-CoV-2.
Conclusiones: La infección por SARS-CoV-2 en pacientes con enfermedad leve se ha relacionado con inmunidad protectora durante tiempo limitado, lo cual podría explicar la presentación de casos de reinfección posterior al evento inicial con demostración de producción de anticuerpos tipo Inmunoglobulina G (IgG).
A pilot study to assess the origin of the spectral power increases of heart rate variability associated with transient changes in the R‐R interval
Authors: Mitsuyama Satoshi , Sakamoto Teruhiko , Nagasawa Toru , Kario Kazuomi , Ozawa Seiji 
Published: January 2024

AbstractSpectral analysis of heart rate variability (HRV) is used to assess cardiovascular autonomic function. In the power density spectrum calculated from a time series of the R‐R interval (RRI), three main components are distinguished: very‐low‐frequency (VLF; 0.003–0.04 Hz), low‐frequency (LF; 0.04–0.15 Hz), and high‐frequency (HF; 0.15–0.4 Hz) components. However, the physiological correlates of these frequency components have yet to be determined. In this study, we conducted spectral analysis of data segments of various lengths (5, 30, 100, and 200 s) of the RRI time series during active standing. Because of the trade‐off relationship between time and frequency resolution, the analysis of the RRI data segment shorter than 30 s was needed to identify the temporal relationships between individual transient increases in RRI and the resulting spectral power changes. In contrast, the segment of 200 s was needed to properly evaluate the magnitude of the increase in the VLF power. The results showed that a transient increase in the RRI was tightly associated with simultaneous increases in the powers of the VLF, LF, and HF components. We further found that the simultaneous power increases in these three components were caused by the arterial baroreceptor reflex responding to rapid blood pressure rise.
The long and the short of it: Salivary telomere length as a candidate biomarker for hypertension and age‐related changes in blood pressure
Authors: Speer Hollie , McKune Andrew J. , Woodward Andrew P. 
Published: January 2024

AbstractHypertension becomes more prevalent with increasing age. Telomere length (TL) has been proposed as a candidate biomarker and can be accessibly extracted from saliva. However, clarity is needed to evaluate the suitability of using TL as a predictor in such instances. This study investigated salivary TL in a cohort of older adults from the 2008 Health and Retirement Study (n = 3329; F: 58%, mean age: 69.4, SD: 10.3 years) to examine any associations with blood pressure (BP). A Bayesian robust regression model was fit using weakly informative priors to predict the effects of TL with age, sex, systolic BP (SBP), diastolic BP (DBP), and treatment status. There were small effects of treatment (β: −0.07, 95% CrI [−0.33, 0.19], pd: 71.91%) and sex (β: −0.10, 95% CrI [−0.27, 0.07], pd: >86.78%). Population effects showed a reduction of 0.01 log2 units in TL with each year of advancing age (95% CrI [−0.01, −0.00]). Conditional posterior predictions suggest that females, and treated individuals, experience greater change in TL with increasing age. Bayes R2 was ~2%. TL declines with increasing age, differs between sexes, and appears to be influenced by antihypertensive drugs. Overall, all effects were weak. The data do not currently support the suitability of salivary TL as a biomarker to predict or understand any age‐related changes in BP.
Das multimodale Chinesen-Image im deutschen Dokumentarfilm
Die

Neue Seidenstraße – Chinas Griff nach Westen
Authors: Chen Jingcao , Li Jing 
Published: January 2024

Zusammenfassung
Deutschland und China gelten als wichtige Knotenpunkte der Neuen Seidenstraße und werden aufgrund ihrer wirtschaftlichen Bedeutung häufig zum Gegenstand der Medienberichterstattung bezüglich der Neuen Seidenstraße. Trotz Anerkennung der Relevanz von der Multimodalität beim Prozess der Sinnbildung bzw. Bedeutungskonstruktion beschäftigen sich die meisten vorangegangenen Untersuchungen zur Imagekonstitution im Zusammenhang mit der neuen Seidenstraße mit schriftlichen Texten (vor allem mit Medienberichten). In dem vorliegenden Beitrag wird der deutsche Dokumentarfilm Die
Neue Seidenstraße – Chinas Griff nach Westen, der mit verschiedenen Modalitäten arbeitet, als Untersuchungsgegenstand ausgewählt und auf das multimodal konstituierte Chinesen-Image untersucht. Von relevanten Ansätzen der multimodalen Analyse und linguistischer Diskursanalyse ausgehend versucht dieser Beitrag, die gängigen Herangehensweisen im Rahmen der Erhellung von Sprachgebrauchsmustern auf die Bildmodalität zu übertragen und dadurch ein sprache-bild-integratives Untersuchungsmodell zu erarbeiten. Aus der Untersuchung ergeben sich insgesamt 4 durch die Zusammenwirkung von Sprach- und Bildmodalität konstituierte Imageaspekte der Chinesen: ‚greifende Fremde‘<fnote> In diesem Beitrag werden die Imageaspekte von Chinesen durch einfache Anführungszeichen gekennzeichnet.</fnote> ‚Gewinner bei der Zusammenarbeit‘ ‚fleißige Opfer‘ und ‚Leiter bei der Zusammenarbeit‘. Diese Arbeit zeigt auch die methodische Relevanz, bei der Imagekonstruktion verschiedene Modalitäten zu berücksichtigen.
Biosynthesis of metal nanoparticles: Bioreduction and biomineralization
Authors: Zhang Dan , Liu Pengran 
Published: January 2024

Abstract
The biosynthesis of metal nanoparticles by plants, bacteria, and cells has been receiving considerable attention in recent years. The traditional synthesis of metal nanoparticles always needed high temperatures, high pressure, and toxic agents. However, the biosynthesis process (including bioreduction and biomineralization) is simpler, safe, economical, and green. The process of biosynthesis can insulate toxic agents, streamline flux, increase the transition efficiency of interactants, and improve the product yield. The biosynthesized metal nanoparticles share similar characteristics with traditional ones, serving as photosensors to achieve light-to-heat/energy transduction, or a drug delivery system. The biosynthetic metal nanoparticles thus could be widely applied in the medical field for disease diagnosis and treatment. It contributed a novel modality for the facile and green synthesis of metal nanoparticles. Increasing studies have been exploring the mechanism for the biosynthesis of metal nanoparticles, devoted to a controllable biosynthesis process. Combined with our previous studies on the biosynthesis of gold nanoparticles with green tea, tumor cells, and cell components, we reviewed the green methods of bioreduction and biomineralization of metal nanoparticles including the internal mechanism, aimed to make a comprehensive introduction to the biosynthesis of metal nanoparticles and relevant biomedical applications, and inspired further research.
Examining the role of activation energy and convective boundary conditions in nanofluid behavior of Couette-Poiseuille flow
Authors: Alzahrani Abdulrahman B. M. 
Published: January 2024

Abstract
This work investigates the behavior of a nanofluid in a horizontal channel under advection boundary conditions within the domain of magnetohydrodynamic radiative Couette-Poiseuille flow. We utilize the Haar wavelet collocation method (HWCM) to investigate the effects of energy activation. This research relies on the mathematical model introduced by Buongiorno, which effectively captures the flow dynamics and incorporates the influence of chemical processes. To streamline the governing flow equations, we employ boundary layer approximations. The HWCM is employed to numerically solve the non-linear coupled partial differential equations that regulate momentum, heat transport, and mass transfer processes. We examine the impact of several dimensionless convergence parameters on the velocity, temperature, and concentration profiles and give visual representations of these results. It is crucial to highlight that the activation energy of the specific chemical reaction is directly linked to the concentration of nanoparticles. The effect of Brownian motion on nanoparticle concentration varies from that of the thermophoresis parameter.
On the topological covering properties by means of generalized open sets
Authors: Sarkar Susmita , Bal Prasenjit , Rakshit Debjani 
Published: January 2024

Abstract
By utilizing

g

g

-open sets, we developed the ideas of GO-Mengerness and GO-Lindelöfness in this article. The structure of GO-compactness is compared to these topological covering features. In addition, some novel GO-compactness characterization has been investigated using nets and filter bases.
‘Problems’ at School: Mathematical Testimonies from the Fayum in the Roman Period
Authors: Savio Martina 
Published: January 2024

Abstract
The common association between the teaching of numbers and basic arithmetical operations, on the one hand, and the earliest levels of linguistic-literary education, on the other, is a datum on which interpreters of Greek papyrological sources are now essentially agreed. A more controversial and less often considered question is whether, in these same ‘scholastic courses’, this basic knowledge also encompassed geometrical and metrological calculations in the form of ‘problems’ (which are typical of the papyrological mathematical tradition). Only a few witnesses to the latter type of texts in Greek have characteristics that would most likely associate them with instructional contexts. The four oldest of these date between the 1st and 3rd centuries AD and are of proven or hypothetical Fayumic provenance. Although they are few in number, these witnesses attest to certain practices in the teaching of mathematics, at least in this historical-geographical context, which are worthy of note.
The Library of the Taurinus Family (5th–6th c.): A Tentative Assessment and Interpretation
Authors: Fournet Jean-Luc 
Published: January 2024

Abstract
The literary papyri found by Otto Rubensohn on January 25 and 27, 1905, were unearthed together with the archive of the Taurinus family (5th–6th c.) in a dump at Hermopolis. Herwig Maehler proposed that, due to the circumstances of their discovery, these books may have belonged to one of the family members. This hypothesis, if correct, is all the more interesting since it makes these papyri one of the few papyrological libraries with a precise historical context. In this paper, I attempt to make an overall assessment of this library, which has never been inventoried, and discuss its possible relationship with the documentary archive of the Taurini.
Amnesia after repeated head impact is caused by impaired synaptic plasticity in the memory engram
Authors: Chapman Daniel P. , Power Sarah D. , Vicini Stefano , Ryan Tomás J. , Burns Mark P. 
Published: January 2024

Sub-concussive head impacts are associated with the development of acute and chronic cognitive deficits. We recently reported that high-frequency head impact (HFHI) causes chronic cognitive deficits in mice through synaptic changes. To better understand the mechanisms underlying HFHI-induced memory decline, we used TRAP2/Ai32 transgenic mice to enable visualization and manipulation of memory engrams.We labeled the fear memory engram in male and female mice exposed to an aversive experience and subjected them to sham or HFHI. Upon subsequent exposure to natural memory recall cues, sham, but not HFHI mice, successfully retrieved fearful memories. In sham mice the hippocampal engram neurons exhibited synaptic plasticity, evident in amplified AMPA:NMDA ratio, enhanced AMPA-weighted tau, and increased dendritic spine volume compared to non-engram neurons. In contrast, although HFHI mice retained a comparable number of hippocampal engram neurons, these neurons did not undergo synaptic plasticity. This lack of plasticity coincided with impaired activation of the engram network, leading to retrograde amnesia in HFHI mice. We validated that the memory deficits induced by HFHI stem from synaptic plasticity impairments by artificially activating the engram using optogenetics, and found that stimulated memory recall was identical in both sham and HFHI mice.Our work shows that chronic cognitive impairment after HFHI is a result of deficiencies in synaptic plasticity instead of a loss in neuronal infrastructure, and we can reinstate a forgotten memory in the amnestic brain by stimulating the memory engram. Targeting synaptic plasticity may have therapeutic potential for treating memory impairments caused by repeated head impacts.
Clinical, Genomic, and Immunological Characterization of RSV Surge in Sydney, Australia, 2022
Authors: Walker Gregory J. , Foster Charles S.P. , Sevendal Andrea , Domazetovska Ana , Kamalakkannan Abbish , Williams Phoebe C.M. , Kim Ki Wook , Condylios Anna , Stelzer-Braid Sacha , Bartlett Adam W. , Rawlinson William 
Published: January 2024

OBJECTIVES:
The 2022 seasonal respiratory syncytial virus (RSV) epidemic in Sydney, Australia saw an unprecedented number of RSV detections. We aimed to characterize genomic and immunologic factors associated with the surge in RSV cases.

METHODS:
Whole genome sequences of RSV were generated from 264 RSV-infected infants and linked to case-matched clinical data from the 2022 southern hemisphere RSV season. We then performed an immunologic analysis of baseline RSV-specific humoral immunity in women of childbearing age before and throughout the coronavirus disease 2019 pandemic.

RESULTS:
Clinical analysis revealed a high burden of disease across patients of all health backgrounds. More than one-half of RSV-related health care visits by infants resulted in hospitalization, and one-quarter required high-flow respiratory support or a higher level of care. Viral phylogenetic analyses revealed that 2022 Sydney RSV sequences were closely related to viruses that had been circulating globally since 2017, including those detected in recent US outbreaks. Nonsynonymous mutations within the palivizumab and nirsevimab binding sites were detected at low frequencies. There was no difference in baseline RSV-neutralizing antibody titers between 2020 and 2022.

CONCLUSIONS:
Collectively, these findings suggest that neither the emergence of a novel RSV genotype nor hypothesized immune debt was associated with the surge of RSV cases and hospitalizations in 2022. Continued genomic and immunologic surveillance is required to further understand the factors driving outbreaks of RSV globally, and to inform guidelines for the rollout and ongoing use of recently developed immunotherapeutics and vaccines.
The Bible in the Aramaic Bowls: Between Memorization, Orality, and Writtenness
Authors: Molin Dorota 
Published: January 2024

Abstract
The Jewish Aramaic incantation bowls from talmudic Babylonia quoted biblical material as part of their written spells, in order to bolster the apotropaic ritual. Current scholarship is making it increasingly apparent that these spells were part of the Jewish “mainstream,” rather than its margins. The bowl spells were often (sometimes?) produced by professional scribes many of whom—as I argue here —were also steeped in Jewish Scripture and liturgy. Moreover, given the high number of artifacts found, the spells can be considered representative of widespread religious practices and beliefs. The quotations are thus an unparalleled (and the only Babylonian epigraphic) source for the study of pre-Masoretic Bible traditions. The orthographic practices encountered in the biblical quotations become a lens through which to view attitudes to the Bible’s “writtenness” and the functions of writtenness, orality, and different types of memory. On the one hand, many spells provide evidence for the prominence of orality and memorization in Bible transmission and its reproduction. On the other, many bowls also imply a conceptual prestige of writtenness, alongside scribal training. At the same time, most bowls suggest a degree of self-sufficiency of the Bible as an oral, memorized, and liturgical text. While the Bible was construed as a written authority by the rabbis, in practice, its written component was likely neither always present, nor strictly necessary for achieving spiritual efficacy within the spells.
Calidad de vida relacionada con la salud en pacientes con enfermedad renal crónica terminal
Authors: Nápoles-Zaldivar Yoander , Palacios Ivonne María Nodarse 
Published: January 2024

Introducción: El incremento en la incidencia de la Enfermedad renal crónica, junto a las modificaciones que provoca en los estilos de vida de los pacientes el someterse a tratamientos sustitutivos de la función renal para prolongar la vida, ha impulsado a cuantificar los efectos de la enfermedad y del tratamiento sobre la calidad de vida.
Objetivo: Evaluar la calidad de vida relacionada con la salud en pacientes con enfermedad renal crónica terminal atendidos en el Servicio de Nefrología del Hospital Clínico-Quirúrgico Docente Dr. “Carlos Font Pupo” en febrero de 2019.
Material y Métodos: Se realizó un estudio observacional descriptivo transversal en 20 pacientes con enfermedad renal crónica terminal. La información se obtuvo a partir de entrevistas semiestructuradas y de las respuestas del cuestionario Kidney Disease Quality of Life Short Form versión 1.3. Para dar cumplimiento al objetivo se utilizaron estadísticas descriptivas a forma de Frecuencias Absolutas, media, desviación estándar y la prueba de U de Mann-Whitney.
Resultados: Las dimensiones genéricas más comprometidas fueron Rol físico (18,75 ± 17,91), Energía/fatiga (48 ± 21,79) y Percepción general de la salud (50,5 ± 22,41). En las dimensiones específicas se obtuvieron las puntuaciones más bajas en Estatus laboral (9 ± 18,89), Función sexual (44,38 ± 46,68) y Carga de la enfermedad renal (52,5 ± 21,88). El 50% de los pacientes presentaron una calidad de vida media.
Conclusiones: Los resultados obtenidos en las diferentes dimensiones no difieren significativamente de estudios internacionales consultados que aplicaron este instrumento.