bluuebunny/crossref_metadata_2025_split huggingface dataset:
(R)‐(+)‐2‐Hydroxy‐1,2,2‐Triphenylethyl Acetate
Authors: Braun Manfred , Gräf Silke , Herzog Sabine 
Published: November 2003

Abstract

(R)‐(+)‐2‐hydroxy‐1,2,2‐triphenylethyl acetate

intermediate: (R)‐(+)‐1,1,2‐Triphenylethanediol

product: (R)‐(+)‐2‐Hydroxy‐1,2,2‐triphenylethyl acetate [(R)‐HYTRA]

reactant: methyl (R)‐(−)‐mandelate

reactant: (R)‐(−)‐mandelic acid (BASF AG, D‐Ludwigshafen)
Benzocyclobutenone by Flash Vacuum Pyrolysis
Authors: Schiess Peter , Barve Ppatibha V. , Dussy Franz E. , Pfiffner Andreas 
Published: November 2003

Abstract

Benzocyclobutenone by flash vacuum pyrolysis

reactant: 2‐toluic acid chloride (240 g, 1.55 mol)

product: Benzocyclobutenone

byproduct: benzyl chloride

reactant: 106 g of almost colorless 2‐toluic acid
Generation of N,N‐Diethylcarbamoyllithium Via Lithium‐Tellurium Exchange and its Reaction with 3‐Phenylpropanal: N,N‐Diethyl‐2‐Hydroxy‐4‐Phenylbutanamide
Authors: Kambe Nobuaki , Inoue Toru , Sonoda Noboru 
Published: November 2003

Abstract

Generation of N,N‐diethylcarbamoyllithium via lithium‐tellurium exchange and its reaction with 3‐phenylpropanal: N,N‐diethyl‐2‐hydroxy‐4‐phenylbutanamide

reactant: Finely ground elemental tellurium (13.40 g, 105 mmol)

byproduct: dibutyl telluride

product: N,N‐diethyl‐2‐hydroxy‐4‐phenylbutanamide

product: N,N‐diethylphenylglyoxylamide [Et
2
NC(O)C(O)Ph]
1,3‐Diols from Lithium β‐Lithioalkoxides Generated by the Reductive Lithiation of Epoxides: 2,5‐Dimethyl‐2,4‐Hexanediol
Authors: Mudryk Boguslaw , Cohen Theodore 
Published: November 2003

Abstract1,3‐Diols from lithium β‐lithioalkoxides generated by the reductive lithiation of epoxides: 2,5‐dimethyl‐2,4‐hexanediolproduct: 2,5‐Dimethyl‐2,4‐hexanediolproduct: 5‐methyl‐2,4‐hexanediolproduct: 1‐p‐anisyl‐1,3‐butanediolproduct: 2‐(1‐hydroxy‐2‐methylpropyl)cyclohexanol
Spiroannelation of Enol Silanes: 2‐Oxo‐5‐Methoxysplro[5.4]Decane
Authors: Lee Thomas V. , Porter John R. 
Published: November 2003

Abstract

Spiroannelation of enol silanes: 2‐oxo‐5‐methoxysplro[5.4]decane

intermediate: 1‐bromo‐3,3‐dimethoxypropane

solvent: petroleum ether (10 mL)

intermediate: 1‐trimethylstannyl‐3,3‐dimethoxypropane

reactant: trimethylsilyl trifluoromethanesulfonate (1.47 g; 6.6 mmol)

catalyst: titanium tetrachloride (7.40 g, 39.0 mmol) in dichloromethane (10 mL)

product: 2‐oxo‐5‐methoxyspiro[5.4]decane

reactant: Cyclohexane carboxaldehyde was obtained from the Aldrich Chemical Company, Inc.
1‐Trifluoromethyl‐1‐Cyclohexanol
Authors: Ramaiah Pichika , Krishnamurti Ramesh , Prakash G. K. Surya 
Published: November 2003

Abstract

1‐Trifluoromethyl‐1‐cyclohexanol

reactant: bromotrifluoromethane

intermediate: (trifluoromethyl)trimethylsilane

product: 1‐trifluoromethyl‐1‐cyclohexanol
Conversion of Amines to Phospho Esters: Decyl Diethyl Phosphate
Authors: Nikolaides Nick , Schipor Ioanna , Ganem Bruce 
Published: November 2003

Abstract

Conversion of amines to phospho esters: decyl diethyl phosphate

reactant: 10.0 mL (0.05 mol) of decylamine

solvent: 35 mL (0.25 mol) of triethylamine

reactant: 7.4 mL (0.05 mol) of diethyl chlorophosphate

product: Decyl diethyl phosphate.

intermediate: 14 g (0.048 mol) of diethyl decylphosphoramidate

byproduct: decyl isoamyl ether
2,2′‐Bi‐5,6‐Dihydro‐1,3‐Dithiolo[4,5‐b][1,4]Dithiinylidene (BEDT‐TTF)
Authors: Larsen Jan , Lenoir Christine 
Published: November 2003

Abstract

2,2′‐bi‐5,6‐dihydro‐1,3‐dithiolo[4,5‐b][1,4]dithiinylidene (BEDT‐TTF)

intermediate: 2‐oxo‐1,4‐dithiane

intermediate: 3‐Chloro‐2‐oxo‐1,4‐dithiane

reactant: potassium O‐(2‐propyl) dithiocarbonate (13.1 g, 0.075 mol)

intermediate: 2‐Oxo‐3‐(2‐propoxythiocarbonylthio)‐1,4‐dithiane

intermediate: 2‐oxo‐5,6‐dihydro‐1,3‐dithiolo[4,5b][1,4]dithiin

product: 2,2′‐Bi‐5,6‐dihydro‐1,3‐dithiolo[4,5‐b][1,4]dithiinylidene(BEDT‐TTF)
Alkylidenation of Ester Carbonyl Groups: (Z)‐1‐Ethoxy‐1‐Phenyl‐1‐Hexene
Authors: Takai Kazuhiko , Kataoka Yasutaka , Miyai Jiro , Okazoe Takashi , Oshima Koichiro , Utimoto Kiitiro 
Published: November 2003

Abstract

Alkylidenation of ester carbonyl groups: (Z)‐1‐ethoxy‐1‐phenyl‐1‐hexene

reactant: 20 g (0.20 mol) of dry diisopropylamine

reactant: 15 mL (38 g, 0.22 mol) of dibromomethane

reactant: 22 mL (37 g, 0.20 mol) of 1‐iodobutane

reactant: 120 mL of hexamethylphosphoric triamide

reactant: 1,1‐dibromopentane

catalyst: 140 mL (0.28 mol) of a 2.0 M solution of titanium tetrachloride

solvent: 84 mL (0.56 mol) of tetramethylethylenediamine

catalyst: 0.88 g (3.2 mmol) of lead (II) chloride

product: 93:7 mixture of (Z)‐ and (E)‐1‐ethoxy‐1‐phenyl‐1‐hexene
A Simple and Convenient Method for the Oxidation of Organoboranes Using Sodium Perborate: (+)‐Isopinocampheol
Authors: Kabalka George W. , Maddox John T. , Shoup Timothy , Bowers Karla R. 
Published: November 2003

Abstract

A Simple and convenient method for the oxidation of organoboranes using sodium perborate: (+)‐isopinocampheol

intermediate: (+)‐Diisopinocampheylborane

intermediate: (+)‐Isopinocampheol

reactant: (1S)‐(−)‐α‐Pinene [99%, 98% optical purity, [α]25D −50.6° neat] was purchased from Aldrich Chemical Company, Inc.
Double Hydroxylation Reaction for Construction of the Corticoid Side Chain: 16α‐Methylcortexolone
Authors: Horiguchi Yoshiaki , Nakamura Eiichi , Kuwajima Isao 
Published: November 2003

Abstract

Double hydroxylation reaction for construction of the corticoid side chain: 16α‐methylcortexolone

intermediate: (Z)‐16α‐methyl‐20‐trimethylsiloxy‐4,17(20)‐pregnadien‐3‐one

product: 16α‐Methylcortexolone
(+)‐(2R,8aR*)‐[(8,8‐Dimethoxycamphoryl)Sulfonyl]Oxaziridine and (+)‐(2R,8aR*)‐[(8,8‐Dichlorocamphoryl)Sulfonyl]Oxaziridine
Authors: Chen Bang‐Chi , Murphy Christopher K. , Kumar Anil , Reddy R. Thimma , Clark Charles , Zhou Ping , Lewis Bryan M. , Gala Dinesh , Mergelsberg Ingrid , Scherer Dominik , Buckley Joseph , DiBenedetto Donald , Davis Franklin A. 
Published: November 2003

Abstract

(+)‐(2R,8aR*)‐[(8,8‐Dimethoxycamphoryl)Sulfonyl]Oxaziridine and (+)‐(2R,8aR*)‐[(8,8‐Dichlorocamphoryl)Sulfonyl]Oxaziridine

intermediate: (−)‐(3‐oxocamphorylsulfonyl)imine

intermediate: (+)‐(7,7‐dimethoxy camphorylsulfonyl)imine

intermediate: (+)‐(7,7‐dichlorocamphorylsulfonyl)imine

product: (+)‐(2R,8aR*)‐[(8,8‐dimethoxycamphoryl)sulfonyl]oxaziridine (1)

product: (−)‐(2S,8aR*)‐[(8,8‐dimethoxycamphoryl)sulfonyl]oxaziridine

product: (+)‐(2R,8aR*)‐[(8,8‐dichlorocamphoryl)sulfonyl] oxaziridine (2)

product: (−)‐(2S,8aR*)‐[(8,8‐dichlorocamphoryl)sulfonyl]oxaziridine
Asymmetric Synthesis of trans‐2‐Aminocyclohexanecarboxylic Acid Derivatives from Pyrrolobenzodiazepine‐5,11‐diones: (1S,2S)‐2‐(N‐Tosylamino)Cyclohexanecarboxylic Acid
Authors: Schultz Arthur G. , Alva Carlos W. 
Published: November 2003

Abstract

Asymmetric synthesis of trans‐2‐aminocyclohexanecarboxylic acid derivatives from pyrrolobenzodiazepine‐5,11‐diones: (1S,2S)‐2‐(N‐tosylamino)cyclohexanecarboxylic acid

intermediate: (5aS,9aS,11aS)‐Perhydro‐5H‐pyrrolo[2,1‐c][1,4]benzodiazepine‐5,11‐dione

intermediate: (1S,2S)‐2‐(N‐Tosylamino)‐1‐[((2S)‐2‐carbomethoxypyrrolidinyl)carbonyl] cyclohexane

product: (1S,2S)‐2‐(N‐Tosylamino)cyclohexanecarboxylic acid
Diethyl (2S,3R)‐2‐(N‐tert‐butoxycarbonyl)amino‐ 3‐Hydroxysuccinate
Authors: Saito Seiki , Komada Kanji , Moriwake Toshio 
Published: November 2003

Abstract

Diethyl (2S,3R)‐2‐(N‐tert‐butoxycarbonyl)amino‐ 3‐hydroxysuccinate

intermediate: diethyl (2S,3S)‐2‐bromo‐3‐hydroxysuccinate

intermediate: diethyl (2R,3R)‐2,3‐epoxysuccinate (3)

intermediate: diethyl (2S,3R)‐2‐azido‐3‐hydroxysuccinate (4)

product: diethyl (2S,3R)‐2‐(N‐tert‐butoxycarbonyl)amino‐3‐hydroxysuccinate (5)
Enantiomerically Pure β‐Amino Acids from 2‐
tert
‐Butyl‐1‐Carbomethoxy‐2,3‐Dihydro‐4(1H)‐Pyrimidinone: (R)‐3‐Amino‐3‐(p‐Methoxyphenyl)Propionic Acid
Authors: Lakner F. J. , Chu K. S. , Negrete G. R. , Konopelski J. P. 
Published: November 2003

Abstract

Enantiomerically pure β‐amino acids from 2‐
tert
‐butyl‐1‐carbomethoxy‐2,3‐dihydro‐4(1H)‐pyrimidinone: (R)‐3‐amino‐3‐(p‐methoxyphenyl)propionic acid

intermediate: (S,S)‐2‐tert‐Butyl‐1‐carbomethoxy‐6‐carboxy‐2,3,5,6‐tetrahydro‐4(1H)‐pyrimidinone, 1

intermediate: (S)‐2‐tert‐Butyl‐1‐carbomethoxy‐2,3‐dihydro‐4(1H)‐pyrimidinone, 3

intermediate: 2 as a clear, colorless syrup

intermediate: (R)‐2‐tert‐Butyl‐6‐(4‐methoxyphenyl)‐5,6‐dihydro‐4(1H)‐pyrimidinone

product: (R)‐3‐Amino‐3‐(p‐methoxyphenyl)propionic acid

intermediate: acyl aminal
2‐Cyclohexene‐1,4‐Dione
Authors: Oda Masaji , Kawase Takeshi , Okada Tomoaki , Enomoto Tetsuya 
Published: November 2003

Abstract

2‐cyclohexene‐1,4‐dione

intermediate: endo‐Tricyclo[6.2.1.02,7]undeca‐4,9‐diene‐3,6‐dione 1.

intermediate: endo‐Tricyclo[6.2.1.02,7]undec‐9‐ene‐3,6‐dione 2.

product: 2‐cyclohexene‐1,4‐dione 3
Conversion of Methyl Ketones into Terminal Acetylenes: Ethynylferrocene
Authors: Polin Johann , Schottenberger Herwig 
Published: November 2003

Abstract

Conversion of methyl ketones into terminal acetylenes: Ethynylferrocene

reactant: 22.8 g (0.1 mol) of acetylferrocene

solvent: 25 mL (0.32 mol) of N,N‐dimethylformamide (DMF)

reactant: 25 mL (0.27 mol) of phosphorus oxychloride

intermediate: (2‐formyl‐1‐chlorovinyl)ferrocene

solvent: 300 mL of anhydrous 1,4‐dioxane

product: ethynylferrocene
4,5‐Dibenzoyl‐1,3‐Dithiole‐2‐Thione
Authors: Hansen Thomas K. , Becher Jan , Jørgensen Tine , Varma K. Sukumar , Khedekar Rajesh , Cava Michael P. 
Published: November 2003

Abstract

4,5‐dibenzoyl‐1,3‐dithiole‐2‐thione

product: 4,5‐Dibenzoylthio‐1,3‐dithiole‐2‐thione (3)

intermediate: 16 g (0.0223 mol) of tetraethylammonium bis(1,3‐dithiole‐2‐thione‐4,5‐dithio) zincate (2)
Acetylenic Ethers From Alcohols and Their Reduction to
Z
‐ and
E
‐Enol Ethers: Preparation of 1‐Menthoxy‐1‐Butyne from Menthol and Conversion to (Z)‐ and (E)‐1‐Menthoxy‐1‐Butene
Authors: Kann Nina , Bernardes Vania , Greene Andrew E. 
Published: November 2003

Abstract

Acetylenic ethers from alcohols and their reduction to Z‐ and E‐enol ethers: Preparation of 1‐menthoxy‐1‐butyne from menthol and conversion to (Z)‐ and (E)‐1‐menthoxy‐1‐butene

product: 1‐Menthoxy‐1‐butyne

product: (Z)‐1‐Menthoxy‐1‐butene

product: (E)‐1‐Menthoxy‐1‐butene

byproduct: menthoxyacetylene

product: adamantyloxyacetylene
Pyridine‐Derived Triflating Reagents: N‐(2‐Pyridyl)‐Triflimide and N‐(5‐Chloro‐2‐Pyridyl)Triflimide
Authors: Comins Daniel L. , Dehghani Ali , Foti Christopher J. , Joseph Sajan P. 
Published: November 2003

Abstract

Pyridine‐derived triflating reagents: N‐(2‐pyridyl)‐triflimide and N‐(5‐chloro‐2‐pyridyl)triflimide

product: N‐(2‐pyridyl)triflimide

product: N‐(5‐chloro‐2‐pyridyl)triflimide
Bis(Trimethylsilyl) Peroxide (BTMSPO)
Authors: Dembech P. , Ricci A. , Seconi G. , Taddei M. 
Published: November 2003

Abstract

Bis(trimethylsilyl) peroxide (BTMSPO)

intermediate: Diazabicyclooctane‐hydrogen peroxide (DABCO · 2H2O2) complex

product: Bis(trimethylsilyl) peroxide (BTMSPO)
Rhodium‐Catalyzed Heterocycloaddition of a Diazomalonate and a Nitrile: 4‐Carbomethoxy‐5‐Methoxy‐2‐Phenyl‐1,3‐Oxazole
Authors: Tullis Joshua S. , Helquist Paul 
Published: November 2003

AbstractRhodium‐catalyzed heterocycloaddition of a diazomalonate and a nitrile: 4‐carbomethoxy‐5‐methoxy‐2‐phenyl‐1,3‐oxazoleintermediate: dimethyl diazomalonateproduct: 4‐carbomethoxy‐5‐methoxy‐2‐phenyl‐1,3‐oxazolereactant: diazo formylacetate (2)
Catalytic Asymmetric Allylation Reactions:(S)‐1‐(Phenylmethoxy)‐4‐Penten‐2‐ol
Authors: Keck Gary E. , Krishnamurthy Dhileepkumar 
Published: November 2003

Abstract

Catalytic asymmetric allylation reactions:(S)‐1‐(phenylmethoxy)‐4‐penten‐2‐ol

catalyst: (S)‐(−)‐1,1′‐bi‐2‐naphthol [(S)‐BINOL] (1.14 g, 4.0 mmol)

product: (S)‐1‐(phenylmethoxy)‐4‐penten‐2‐ol
Ethyl Glycidate from (S)‐Serine: Ethyl (R)‐(+)‐2,3‐Epoxypropanoate
Authors: Petit Y. , Larchevêque M. 
Published: November 2003

AbstractEthyl glycidate from (S)‐serine: Ethyl (R)‐(+)‐2,3‐epoxypropanoateintermediate: potassium glycidateproduct: ethyl glycidateintermediate: (S)‐(−)‐2‐Bromo‐3‐hydroxypropanoic acidproduct: Methyl 2,3‐epoxypropanoate
(4R,5S)‐4,5‐Diphenyl‐3‐Vinyl‐2‐Oxazolidinone
Authors: Akiba T. , Tamura O. , Terashima S. 
Published: November 2003

Abstract

(4R,5S)‐4,5‐diphenyl‐3‐vinyl‐2‐oxazolidinone

intermediate: (4R,5S)‐4,5‐diphenyl‐2‐oxazolidinone

intermediate: (4R,5S)‐3‐(Methoxyethyl)‐4,5‐diphenyl‐2‐oxazolidinone

product: (4S,5R)‐4,5‐diphenyl‐3‐vinyl‐2‐oxazolidinone
Synthesis of Chiral (E)‐Crotylsilanes: [3R‐ and 3S‐]‐(4E)‐Methyl 3‐(Dimethylphenylsilyl)‐4‐Hexenoate
Authors: Beresis Richard T. , Solomon Jason S. , Yang Michael G. , Jain Nareshkumar F. , Panek James S. 
Published: November 2003

Abstract

Synthesis of chiral (E)‐crotylsilanes: [3R‐ and 3S‐]‐(4E)‐methyl 3‐(dimethylphenylsilyl)‐4‐hexenoate

intermediate: (±)‐1‐(Dimethylphenylsilyl)‐1‐buten‐3‐ol (2a)

catalyst: 12 mg (2.05 × 10−5 mol) of bis(η‐divinyltetramethyldisiloxane)tri‐tert‐butylphosphineplatinum(0)

intermediate: (3S)‐1‐(Dimethylphenylsilyl)‐1‐buten‐3‐ol (3a)

intermediate: (3R)‐1‐(dimethylphenylsilyl)‐1‐buten‐3‐ol acetate (3b)

intermediate: (3R)‐1‐(Dimethylphenylsilyl)‐1‐buten‐3‐ol (3c)

product: (3S, 4E)‐Methyl 3‐(dimethylphenylsilyl)‐4‐hexenoate (4a)
Synthesis of β‐Lactones by Aldolization of Ketones with Phenyl Ester Enolates:3,3‐Dimethyl‐1‐Oxaspiro[3.5]Nonan‐2‐One
Authors: Wedler Christine , Schick Hans 
Published: November 2003

Abstract

Synthesis of β‐lactones by aldolization of ketones with phenyl ester enolates: 3,3‐dimethyl‐1‐oxaspiro[3.5]nonan‐2‐one

reactant: phenyl 2‐methylpropanoate (27.09 g, 0.165 mol) in THF (50 mL)

product: 3,3‐dimethyl‐1‐oxaspiro[3.5]nonan‐2‐one

product: (±)‐3‐ethyl‐1‐oxaspiro[3.5]nonan‐2‐one

product: (3R*,4R*)‐ and (3R*,4S*)‐4‐isopropyl‐4‐methyl‐3‐octyl‐2‐oxetanone
Photoinduced‐Addition of Methanol to (5S)‐(5‐O‐tert‐Butyldimethylsiloxymethyl)Furan‐2(5H)‐One: (4R,5S)‐4‐Hydroxymethyl‐(5‐O‐tert‐Butyldimethylsiloxymethyl)Furan‐2(5H)‐One
Authors: Mann John , Weymouth‐Wilson Alexander C. 
Published: November 2003

Abstract

Photoinduced‐addition of methanol to (5S)‐(5‐O‐tert‐butyldimethylsiloxymethyl)furan‐2(5H)‐one: (4R,5S)‐4‐hydroxymethyl‐(5‐O‐tert‐butyldimethylsiloxymethyl)furan‐2(5H)‐one

intermediate: methyl (4S)‐4,5‐O‐isopropylidenepent‐(2Z)‐enoate

intermediate: (S)‐5‐hydroxymethylfuran‐2(5H)‐one

intermediate: (5S)‐(5‐O‐tert‐butyldimethylsiloxymethyl)furan‐2(5H)‐one

product: (4R,5S)‐4‐Hydroxymethyl‐(5‐O‐tert‐butyldimethylsiloxymethyl)furan‐2(5H)‐one

reactant: 23.7 g (0.13 mol) of benzophenone

byproduct: benzpinacol

byproduct: (4R,5S)‐4‐diphenylhydroxymethyl‐5‐tert‐butyldimethylsiloxymethylfuran‐2(5H)‐one
Wittig Olefination of Perfluoroalkyl Carboxylic Esters; Synthesis of 1,1,1‐Trifluoro‐2‐Ethoxy‐5‐Phenylpent‐2‐Ene and 1‐Perfluoroalkyl Epoxy Ethers: 1,1,1‐Trifluoro‐2‐Ethoxy‐2,3‐Epoxy‐5‐Phenylpentane
Authors: Bégué Jean‐Pierre , Bonnet‐Delpon Danièle , Kornilov Andrei 
Published: November 2003

Abstract

Wittig olefination of perfluoroalkyl carboxylic esters; synthesis of 1,1,1‐trifluoro‐2‐ethoxy‐5‐phenylpent‐2‐ene and 1‐perfluoroalkyl epoxy ethers: 1,1,1‐trifluoro‐2‐ethoxy‐2,3‐epoxy‐5‐phenylpentane

reactant: 32.3 g (70 mmol) of 3‐phenylpropyltriphenylphosphonium bromide (1)

product: (Z)‐1,1,1‐trifluoro‐2‐ethoxy‐5‐phenyl‐2‐pentene (3)

product: 1,1,1‐trifluoro‐2‐ethoxy‐2,3‐epoxy‐5‐phenylpentane (4)
Selective Protection of 1,3‐Diols at the More Hindered Hydroxy Group: 3‐(Methoxymethoxy)‐1‐Butanol
Authors: Bailey William F. , Carson Matthew W. , Zarcone Lyn M. J. 
Published: November 2003

Abstract

Selective Protection of 1,3‐diols at the more hindered hydroxy group: 3‐(methoxymethoxy)‐1‐butanol

intermediate: 1‐acetoxy‐3‐(methoxymethoxy)butane

product: 3‐(Methoxymethoxy)‐1‐butanol
6,7‐Dihydrocyclopenta‐1,3‐Dioxin‐5(4
H
)‐One
Authors: Chen Kwunmin , Brook Christopher S. , Smith Amos B. 
Published: November 2003

Abstract

(R,R)‐N,N′‐bis(3,5‐di‐tert‐butylsalicylidene)‐1,2‐cyclohexanediamino manganese(III) chloride, a highly enantioselective epoxidation catalyst

product: 6,7‐Dihydrocyclopenta‐1,3‐Dioxin‐5(4H)‐One
3‐Cyclopentene‐1‐Carboxylic Acid
Authors: Deprés Jean‐Pierre , Greene Andrew E. 
Published: November 2003

Abstract

3‐Cyclopentene‐1‐carboxylic Acid

intermediate: 3‐cyclopentene‐1,1‐dicarboxylic acid

product: 3‐cyclopentene‐1‐carboxylic acid
Synthesis of 8,8‐Dicyanoheptafulvene from Cycloheptatrienylium Tetrafluoroborate and Bromomalononitrile
Authors: Takeshita Hitoshi , Mori Akira , Kubo Kanji 
Published: November 2003

Abstract

Synthesis of 8,8‐dicyanoheptafulvene from cycloheptatrienylium tetrafluoroborate and bromomalononitrile

reactant: Bromomalononitrile (14.49 g, 0.1 mol)

product: 8,8‐dicyanoheptafulvene
1S‐(−)‐1,3‐Dithiane 1‐Oxide
Authors: Page Philip C. Bulman , Heer Jag P. , Bethell Donald , Collington Eric W. , Andrews David M. 
Published: November 2003

Abstract

1S‐(−)‐1,3‐dithiane 1‐oxide

intermediate: 2‐(2,2‐dimethylpropanoyl)‐1,3‐dithiane

intermediate: anti‐ and syn‐1S‐(2,2‐dimethylpropanoyl)‐1,3‐dithiane 1‐oxide

product: 1S‐(−)‐1,3‐dithiane 1‐oxide

reactant: (+)‐[(8,8‐dimethoxycamphoryl)sulfonyl]oxaziridine
1‐Chloro‐(2S,3S)‐Dihydroxycyclohexa‐4,6‐Diene
Authors: Hudlicky Tomas , Stabile Michele R. , Gibson David T. , Whited Gregory M. 
Published: November 2003

Abstract

1‐chloro‐(2S,3S)‐dihydroxycyclohexa‐4,6‐diene

product: 1‐chloro‐(2S,3S)‐dihydroxycyclohexa‐4,6‐diene
Methyl (S)‐2‐Phthalimido‐4‐Oxobutanoate
Authors: Meffre Patrick , Durand Philippe , Le Goffic François 
Published: November 2003

Abstract

Methyl (S)‐2‐phthalimido‐4‐oxobutanoate

intermediate: Methyl (S)‐2‐phthalimido‐4‐methylthiobutanoate

product: Methyl (S)‐2‐phthalimido‐4‐oxobutanoate
Dimethyl Squarate and its Conversion to 3‐Ethenyl‐4‐Methoxycyclobutene‐1,2‐Dione and 2‐Butyl‐6‐Ethenyl‐5‐Methoxy‐1,4‐Benzoquinone
Authors: Liu Hui , Tomooka Craig S. , Xu Simon L. , Yerxa Benjamin R. , Sullivan Robert W. , Xiong Yifeng , Moore Harold W. 
Published: November 2003

Abstract

Dimethyl squarate and its conversion to 3‐ethenyl‐4‐methoxycyclobutene‐1,2‐dione and 2‐butyl‐6‐ethenyl‐5‐methoxy‐1,4‐benzoquinone

product: Dimethyl squarate. (1)

product: 3‐Ethenyl‐4‐methoxycyclobutene‐1,2‐dione (2)

product: 2‐Butyl‐6‐ethenyl‐5‐methoxy‐1,4‐benzoquinone (3)

byproduct: methyl formate
Regioselective Monoalkylation of Ketones via their Manganese Enolates: 2‐Benzyl‐6‐Methylcyclohexanone from 2‐Methylcyclohexanone
Authors: Cahiez Gérard , Chau François , Blanchot Bernard 
Published: November 2003

AbstractRegioselective monoalkylation of ketones via their manganese enolates: 2‐benzyl‐6‐methylcyclohexanone from 2‐methylcyclohexanoneproduct: 2‐benzyl‐6‐methylcyclohexanonebyproduct: 2‐benzyl‐2‐methylcyclohexanone
Isomerization of β‐Alkynyl Allylic Alcohols to Furans Catalyzed by Silver Nitrate on Silica Gel: 2‐Pentyl‐3‐Methyl‐5‐Heptylfuran
Authors: Marshall James A. , Sehon Clark A. 
Published: November 2003

Abstract

Isomerization of β‐alkynyl allylic alcohols to furans catalyzed by silver nitrate on silica gel: 2‐pentyl‐3‐methyl‐5‐heptylfuran

intermediate: 2‐bromo‐1‐octen‐3‐ol

intermediate: 7‐methylene‐8‐hexadecyn‐6‐ol

product: 2‐pentyl‐3‐methyl‐5‐heptylfuran
Transformation of Pseudoephedrine Amides into Highly Enantiomerically Enriched Aldehydes, Alcohols, and Ketones
Authors: Myers Andrew G. , Yang Bryant H. , Chen Hou 
Published: November 2003

Abstract

Transformation of pseudoephedrine amides into highly enantiomerically enriched aldehydes, alcohols, and ketones

product: (R)‐α‐methylbenzenepropanal

product: (R)‐β‐methylbenzenepropanol

product: (R)‐2‐methyl‐1‐phenyl‐3‐heptanone

product: (R)‐α‐methylbenzenepropanoic acid

byproduct: (R)‐3‐butyl‐2‐methyl‐1‐phenylheptan‐3‐ol
Synthesis of 1,1‐Dimethylethyl (S)‐4‐Formyl‐2,2‐Dimethyl‐3‐Oxazolidinecarboxylate by Oxidation of the Alcohol
Authors: Dondoni Alessandro , Perrone Daniela 
Published: November 2003

AbstractSynthesis of 1,1‐dimethylethyl (S)‐4‐formyl‐2,2‐dimethyl‐3‐oxazolidinecarboxylate by oxidation of the alcoholintermediate:N‐[(1,1‐Dimethylethoxy)carbonyl]‐L‐serine methyl ester(2).intermediate: methyl serinate hydrochlorideintermediate:3‐(1,1‐Dimethylethyl) 4‐methyl‐(S)‐2,2‐dimethyloxazolidine‐3,4‐dicarboxylate(3).intermediate:N‐[(1,1‐Dimethylethoxy)carbonyl]‐N,O‐isopropylidene‐L‐serinol(4).product:1,1‐Dimethylethyl (S)‐4‐formyl‐2,2‐dimethyl‐3‐oxazolidinecarboxylate(5).
Diastereoselective Synthesis of Protected Vicinal Amino Alcohols: (S)‐2‐[(4S)‐N‐tert‐Butoxycarbonyl‐2,2‐Dimethyl‐1,3‐Oxazolidinyl]‐2‐tert‐Butyldimethylsiloxyethanal from a Serine‐Derived Aldehyde
Authors: Dondoni Alessandro , Perrone Daniela 
Published: November 2003

Abstract

Diastereoselective synthesis of protected vicinal amino alcohols: (S)‐2‐[(4S)‐N‐tert‐butoxycarbonyl‐2,2‐dimethyl‐1,3‐oxazolidinyl]‐2‐tert‐Butyldimethylsiloxyethanal from a serine‐derived aldehyde

intermediate: (S)‐2‐{[(4S)‐N‐tert‐Butoxycarbonyl‐2,2‐dimethyl‐1,3‐oxazolidin‐4‐yl]hydroxymethyl}‐1,3‐thiazole (2)

intermediate: (S)‐2‐{[(4S)‐N‐tert‐Butoxycarbonyl‐2,2‐dimethyl‐1,3‐oxazolidin‐4‐yl]‐tert‐butyldimethylsiloxy}‐1,3‐thiazole (3)

product: (S)‐2‐[(4S)‐N‐tert‐Butoxycarbonyl‐2,2‐dimethyl‐1,3‐oxazolidin‐4‐yl]‐2‐tert‐butyldimethylsiloxyethanal (4)

reactant: N‐Boc‐L‐serinal acetonide
The Synthesis of 2‐Alkyl‐4‐Pyrones from Meldrum's Acid
Authors: Crimmins Michael T. , Washburn David G. , Zawacki Frank J. 
Published: November 2003

Abstract

The synthesis of 2‐alkyl‐4‐pyrones from Meldrum's acid

intermediate: 5‐(1‐Hydroxyethylidene)‐2,2‐dimethyl‐1,3‐dioxane‐4,6‐dione

product: 2‐methyl‐4H‐pyran‐4‐one
The
D
ess‐
M
artin Periodinane: 1,1,1‐Triacetoxy‐1,1‐Dihydro‐1,2‐Benziodoxol‐3(1H)‐One
Authors: Boeckman Robert K. , Shao Pengcheng , Mullins Joseph J. 
Published: November 2003

Abstract

The Dess‐Martin periodinane: 1,1,1‐triacetoxy‐1,1‐dihydro‐1,2‐benziodoxol‐3(1H)‐one

intermediate: 1‐Hydroxy‐1,2‐benziodoxol‐3(1H)‐one 1‐oxide (1)

product: 1,1,1‐Triacetoxy‐1,1‐dihydro‐1,2‐benziodoxol‐3(1H)‐one (2)
Synthesis of 2′‐Deoxyribonucleosides: β‐3′,5′‐Di‐O‐Benzoylthymidine
Authors: Prudhomme Daniel R. , Park Minnie , Wang Zhiwei , Buck Jason R. , Rizzo Carmelo J. 
Published: November 2003

AbstractSynthesis of 2′‐deoxyribonucleosides: β‐3′,5′‐di‐O‐benzoylthymidineintermediate: 1,3,5‐O‐tribenzoyl‐2‐O‐[(3‐trifluoromethyl)benzoyl]‐α‐D‐ribofuranoseintermediate: 2,4‐bis(trimethylsilyloxy)‐5‐methylpyrimidineintermediate: 3′,5′‐di‐O‐benzoyl‐2′‐O‐[(3‐trifluoromethyl)benzoyl]‐5‐methyluridinereactant: 9‐ethyl‐3,6‐dimethylcarbazole (200 mg, 0.9 mmolproduct: 3′,5′‐di‐O‐benzoylthymidinebyproduct: 5′‐O‐benzoyl‐3′‐deoxythymidine
Bis(Pinacolato)Diboron
Authors: Ishiyama Tatsuo , Murata Miki , Ahiko Taka‐aki , Miyaura Norio 
Published: November 2003

AbstractBis(pinacolato)diboronreactant: 218 g (4.84 mol) of dimethylamineintermediate: tris(dimethylamino)boraneintermediate: bromobis(dimethylamino)boraneintermediate: tetrakis(dimethylamino)diboronproduct: Bis(pinacolato)diboron
β‐Mercaptopropionitrile (2‐Cyanoethanethiol)
Authors: Gerber R. Eric , Hasbun Carlos , Dubenko Larisa G. , Fong King Mei , Bierer Donald E. 
Published: November 2003

Abstract

β‐Mercaptopropionitrile (2‐cyanoethanethiol)

intermediate:
2‐Cyanoethylthiouronium hydrochloride

product:
2‐Cyanoethanethiol

product:
3,3′‐Dithiobispropionitrile
Methyl 2,3‐O‐(6,6′‐Octahydro‐6,6′‐Bi‐2H‐Pyran‐2,2′‐Diyl)‐α‐
D
‐Galactopyranoside
Authors: Ley Steven V. , Osborn Helen M.I. 
Published: November 2003

Abstract

Methyl 2,3‐O‐(6,6′‐octahydro‐6,6′‐bi‐2H‐pyran‐2,2′‐diyl)‐α‐
D
‐galactopyranoside

intermediate: 6,6′‐bi(3,4‐dihydro‐2H‐pyran)

product: methyl 2,3‐O‐(6,6′‐octahydro‐6,6′‐bi‐2H‐pyran‐2,2′‐diyl)‐α‐D‐galactopyranoside
6
A
‐O‐p‐Toluenesulfonyl‐β‐Cyclodextrin
Authors: Brady Bernadette , Lynam Nuala , O'Sullivan Thomas , Ahern Cormac , Darcy Raphael 
Published: November 2003

Abstract

6
A
‐O‐p‐toluenesulfonyl‐β‐cyclodextrin

product: 6
A
‐O‐p‐toluenesulfonyl‐β‐cyclodextrin

product: Cyclodextrin monotosylate
Photochemical Synthesis of Bicyclo[1.1.1]Pentane‐1,3‐Dicarboxylic Acid
Authors: Levin Michael D. , Kaszynski Piotr , Michl Josef 
Published: November 2003

Abstract

Photochemical synthesis of bicyclo[1.1.1]pentane‐1,3‐dicarboxylic acid

intermediate: 1,3‐diacetylbicyclo[1.1.1]pentane

product: Bicyclo[1.1.1]pentane‐1,3‐dicarboxylic acid