bluuebunny/crossref_metadata_2025_split huggingface dataset:
Floral scent emission ofEpiphyllum oxypetalum: identification of a novel cytosol-localized geraniol biosynthesis pathway
Authors: Zhang Yiyang , Zhang Yuhan , Tian Qiurui , Wei Likun , Zhu Ting , Zhou Zhiwei , Wang Jiaqi , Liu Zhibin , Tang Wei , Xiao Haijun , Liu Mingchun , Li Tao , Sun Qun 
Published: November 2023

SummaryEpiphyllum oxypetalum, a renowned ornamental species in Cactaceae, releases attractive fragrance during its infrequent, transient and nocturnal flowering, the nature and biosynthesis of the volatiles for this floral scent, however, remained unexplored.Employing volatilomic, transcriptomic and biochemical approaches, we systematically characterized the composition, emission dynamics and biosynthesis ofE. oxypetalumfloral scent.Floral scent composition was highly dynamic, with trans-geraniol comprising 72.54% of the total emission at full bloom, followed by benzyl alcohol (12.96%) and methyl salicylate (3.75%), which predominantly emanated from petals and sepals. Transcriptomic analysis and inhibition assay using pathway-specific inhibitors revealed the mevalonate (MVA) pathway as the precursor source for trans-geraniol biosynthesis. Together with elevated expression of both cytosol-localized geraniol pyrophosphate synthase EoGDPS and geraniol synthase EoTPSa1, we elucidated an unusual cytosolic biosynthesis route for geraniol inE. oxypetalumpetals.Our study onE. oxypetalumscent emission and its biosynthesis offers a comprehensive profile of cactus floral scent profiles and presents a rare case of cytosolic geraniol biosynthesis using MVA pathway-derived substrates. These findings underline the unique metabolism of cactus flower volatiles, which hold a promise to be applied in the development of novel perfumes.
Coagulation activation-induced fibrinolysis biomarker changes depend on thrombophilic risk factors and their clinical phenotype: an interventionalin vivostudy
Authors: Reda Sara , Schwarz Nadine , Müller Jens , McRae Hannah L. , Oldenburg Johannes , Pötzsch Bernd , Rühl Heiko 
Published: November 2023

AbstractBackgroundRecently we have shown alterations in the anticoagulant response to recombinant activated factor VII (rFVIIa)-induced coagulation activation in patients with thrombophilia.ObjectivesHere we extended thisin vivomodel to study fibrinolysis biomarkers.MethodsThe study population included 56 patients with thrombophilia and a history of venous thromboembolism (VTE+), 38 asymptomatic patients with thrombophilia (VTE-) and 35 healthy controls. Plasma levels of D-dimer, plasmin-α2-antiplasmin complex (PAP), and plasminogen activator inhibitor-1 (PAI-1) were monitored over 8 hours after rFVIIa infusion (15 µg/kg) along with thrombin activation markers and activated protein C (APC).ResultsIn all cohorts, PAP increased (P<3.9·10-10) and PAI-1 decreased (P<3.5·10-8). In contrast to thrombin-antithrombin complex (TAT), which also increased temporarily in all cohorts (P<3.6·10-6), changes of PAP and PAI-1 did not reverse during the observation period. The area under the curve (AUC) of PAP (respectively TAT), as measure of plasmin (respectively thrombin) formation, was greater in the VTE+ cohort than in healthy controls (PAP AUCP=0.003, TAT AUCP=2.5·10-4) and showed correlation (r=0.554). As evidenced by the respective AUCs, asymptomatic factor V Leiden (FVL) carriers in the VTE-cohort showed less PAP formation (P=9·10-4), more pronounced PAI-1 decline (P=0.010), and increased APC formation (P=0.020) than those within the VTE+ group (n=19 each). This was not observed in prothrombin 20210G>A carriers or patients with unexplained familial thrombophilia.ConclusionrFVIIa-induced thrombin formation is associated with fibrinolysis parameter changes outlasting the concomitant anticoagulant response. Both correlate with thrombosis history in FVL and might help to explain its variable clinical expressivity.EssentialsImpairment of fibrinolysis might result in increased risk of thrombosis.We studied fibrinolytic biomarkers after coagulation activation by recombinant factor VIIa.Hereby induced alterations in fibrinolytic biomarkers outlast concomitant anticoagulant changes.Factor V Leiden carriers with or without thrombosis showed distinct fibrinolytic changes.
Giotto Suite: a multi-scale and technology-agnostic spatial multi-omics analysis ecosystem
Authors: Chen Jiaji George , Chávez-Fuentes Joselyn Cristina , O’Brien Matthew , Xu Junxiang , Ruiz Edward , Wang Wen , Amin Iqra , Sarfraz Irzam , Guckhool Pratishtha , Sistig Adriana , Yuan Guo-Cheng , Dries Ruben 
Published: November 2023

AbstractEmerging spatial omics technologies continue to advance the molecular mapping of tissue architecture and the investigation of gene regulation and cellular crosstalk, which in turn provide new mechanistic insights into a wide range of biological processes and diseases. Such technologies provide an increasingly large amount of information content at multiple spatial scales. However, representing and harmonizing diverse spatial datasets efficiently, including combining multiple modalities or spatial scales in a scalable and flexible manner, remains a substantial challenge. Here, we present Giotto Suite, a suite of open-source software packages that underlies a fully modular and integrated spatial data analysis toolbox. At its core, Giotto Suite is centered around an innovative and technology-agnostic data framework embedded in the R software environment, which allows the representation and integration of virtually any type of spatial omics data at any spatial resolution. In addition, Giotto Suite provides both scalable and extensible end-to-end solutions for data analysis, integration, and visualization. Giotto Suite integrates molecular, morphology, spatial, and annotated feature information to create a responsive and flexible workflow for multi-scale, multi-omic data analyses, as demonstrated here by applications to several state-of-the-art spatial technologies. Furthermore, Giotto Suite builds upon interoperable interfaces and data structures that bridge the established fields of genomics and spatial data science, thereby enabling independent developers to create custom-engineered pipelines. As such, Giotto Suite creates an immersive ecosystem for spatial multi-omic data analysis.
A primary culture method for the easy, efficient and effective acquisition of oligodendrocyte lineage cells
Authors: Kim Hanki , Kim Bum Jun , Koh Seungyon , Cho Hyo Jin , Jin Xuelian , Kim Byung Gon , Choi Jun Young 
Published: November 2023

AbstractOligodendrocytes (OL) are myelin forming glial cells in the central nervous system.In vitroprimary OL culture models provide the benefit of a more readily controlled environment facilitating the evaluation of diverse OL stages and convoluted dynamics. Conventional methods of primary OL culture do exist, but their performance in terms of efficiency and simplicity has room for improvement. We present a novel method of primary OL culture, namely the E3 (Easy, efficient, and effective) method, which greatly improves cell yield and reduces time required to oligodendrocyte progenitor cell (OPC) acquisition and maturation into OLs. We also provide optimal media compositions for augmentation of OPC proliferation and a more robust maturation into myelin forming OLs.In vitrocharacteristics of the OL lineage discovered during the development of the E3 method present implications for further research on OL physiology and pathophysiology.
Identifying disruptions by COVID-19 and devising strategies to build robust supply chain – a case study illustration of India's energy storage sector
Authors: Singh Shikha , Kumar Sameer , Kumar Adarsh 
Published: November 2023

PurposeThe outset of the COVID-19 pandemic caused disruptions of all forms in the supply chain globally for almost two and a half years. This study identifies various challenges in the effective functioning of the existing supply chain during COVID-19. The focus is to see the disruptions impacting the energy storage supply chains.Design/methodology/approachThe procedure entails a thorough analysis of scholarly literature pertaining to various supply chain interruptions, confirmed and verified by experts working in an energy storage company in India. These experts also confirmed the occurrence of more disruptive factors during their interviews and questionnaire survey. Moreover, this process attempts to filter out the relevant causal disruption factors in an energy storage company by using the integrated approach of qualitative and quantitative methodologies.FindingsThe results provide practical insights for the company management in planning and devising new strategies to manage supply chain disruptions. Supply chains for companies in other industry sectors can also benefit from the proposed framework and results in making them more robust to counter future disastrous events.Originality/valueThe study provides an easily adaptable decision framework to different industries by closely examining supply chain disruptions and identifying associated causes for building a robust supply chain focused on the energy storage sector. It examines four disruption dimensions and investigates possible outcomes and impacts of disruptions.
A conceptual framework of decentralized blockchain integrated system based on building information modeling to steering digital administration of disputes in the IPD contracts
Authors: Faraji Amir , Homayoon Arya Shima , Ghasemi Elnaz , Rashidi Maria , Perera Srinath , Tam Vivian , Rahnamayiezekavat Payam 
Published: November 2023

Purpose
In the construction industry, various parties are involved in a project. Consequently, claims and disputes are inevitable in this industry. This paper aims to develop Integrated project delivery (IPD) practices including early involvement of stakeholders and multiparty contracts which its combination with advanced technologies such as blockchain can lead to better dispute management and improve the whole construction process.

Design/methodology/approach
Based on literature review, the alternative dispute resolution (ADR) for IPD contacts were identified, and three formats of IPD contracts were selected, and the dispute resolution process of them has been analyzed. Then, based on blockchain review, a conceptual blockchain-based dispute management (BDM) model was generated for ADR in IPD. Model validation was done by an interview. Experts were asked to compare the BDM model with the traditional system regarding the ADR duration.

Findings
Analyses of the collected data from the experts demonstrated that the BDM model has better function in terms of time and cost for ADR process when the project is facing serious and considerable number of disputes. The relation between blockchain technology (BCT) and building information modeling (BIM) has been examined through a framework, and the ability of the proposed model for administrating dispute resolution process has been verified using four different scenarios of construction claims that show the system can run successfully.

Originality
The current study proposes a truthful model, reliable framework to address the problem of project dispute management in IPD contracts. The system combines the ability to being unchangeable and the reliability characteristics of BCT with informative and automation aspects of BIM together to improve dispute resolution issue in the IPD system.
Does the sharing of leadership increase the coherence of a school's instructional framework?
Authors: Zhan Xi , Goddard Roger , Anthony Anika 
Published: November 2023

PurposeExisting research suggests that organizational learning, jointly implemented by principals and teachers may reduce agency risks and improve school management effectiveness. However, research investigating how this process occurs is lacking. The relationship between school leaders promoting the involvement of teachers in school-wide processes focused on instructional improvement and the coherence characterizing a school's instructional program remains unclear.Design/methodology/approachThe authors identified shared instructional leadership and instructional coherence, as two key variables describing the process of organizational learning and the outcome of agency risk reduction. The authors employed hierarchical linear modeling to test the hypothesis that shared leaderships positively predicts differences among schools in instructional coherence.FindingsBased on a sample of 113 public high schools selected from a U.S. Midwestern state, the results confirm the hypothesis.Research limitations/implicationsThis study uses the existing theoretical and empirical findings to interpret the potential relationship between shared leadership and instructional coherence, and validates it through empirical data analysis. The findings expand the understanding of the shared leadership theory. Although the design of this study is strictly based on theoretical and empirical findings, and part of the purpose of the research is to find the reasons why shared leadership seems to be insignificant in some countries and regions, readers should still note that the sample source is American schools. The findings of this study are worth examining with different samples in future studies.Practical implicationsSince the direct relationship between shared leadership and student standardized test scores has been difficult to measure, and in some countries even negative, there is debate about the need for shared leadership. The difficulty of measurement is caused by the diversity of leadership subjects and the complexity of leadership tasks. This study finds out the direct object of shared leadership and the process of exerting its effects, which will expand the understanding of the positive meaning of shared leadership. This will help different countries and regions better identify and play the role of shared leadership.Originality/valueBased on the combination of organizational learning theory, agency theory and shared leadership theory, the study modeled the process of collaborative organizational learning among principals and teachers. The study employed instructional coherence as a form of structured organizational learning that is a prerequisite for improvement in common measures of student learning such as standardized test scores. Do so provide practical guidance for educators seeking improvement through organizational learning.
The real implications of mimicking peer firms' cash holdings
Authors: Kadzima Marvelous , Machokoto Michael , Chamisa Edward 
Published: November 2023

PurposeThis study empirically examines the nonlinear effects of mimicking peer firms' cash holdings on shareholder value, with consideration of macroeconomic conditions.Design/methodology/approachAn instrumental variable approach for nonlinear models is estimated for a large sample of US firms over the period 1991–2019. This approach addresses the reflection problem in examining peer effects, whereby it is impossible to separate the individual's effects on the group, or vice versa, if both are simultaneously determined.FindingsThe authors find an inverted U-shaped association between shareholder value and mimicking intensity of peer firms' cash holdings. This result suggests that mimicking peer firms' cash holdings is subject to diminishing returns. It is more beneficial at lower levels of mimicking intensity but less so or suboptimal at higher levels. Further evidence indicates that this inverted U-shaped shareholder value-mimicking intensity nexus is asymmetric. Specifically, it is salient for decreases relative to increases in cash holdings and, more importantly, in good relative to bad macroeconomic states. The findings are robust to several concerns and have important implications for liquidity management policies.Originality/valueThe authors provide new empirical evidence of the nonlinear effects of mimicking peer firms' cash holdings on shareholder value, which varies with macroeconomic conditions.
Sociopolitical and financial goals in state-owned manufacturers' expansion of production capacity: evidence from China
Authors: Gao Renfei , Lu Jane , Hu Helen Wei , Martin Geoff 
Published: November 2023

PurposeThe rapid, yet low-profit, expansion of the production capacity of state-owned enterprises (SOEs) represents a remarkable phenomenon. However, the motivation behind this key operational decision remains underexplored, especially concerning the prioritization of sociopolitical and financial goals in operations management. Drawing on the multiple-goal model in the behavioral theory of the firm (BTOF), the authors' study aims to examine how SOE capacity expansion is driven by performance feedback regarding the sociopolitical goal of employment provision and how SOEs differently prioritize sociopolitical and financial goals based on negative versus positive feedback on the sociopolitical goal.Design/methodology/approachThe authors' study uses panel data on 826 Chinese SOEs in manufacturing industries from 2011 to 2019. The authors employ the fixed-effects model with Driscoll–Kraay standard errors, which are robust to heteroscedasticity, autocorrelation and cross-sectional dependence.FindingsThe authors find that SOEs increase capacity expansion as sociopolitical feedback becomes more negative, but they may not increase capacity expansion in response to positive sociopolitical feedback. Moreover, negative profitability feedback strengthens SOEs' capacity expansion in response to negative sociopolitical feedback. In contrast, negative profitability feedback weakens their response to positive sociopolitical feedback.Originality/valueThe authors' study offers a novel behavioral explanation of SOEs' operational decisions regarding capacity expansion. While the literature has traditionally assumed multiple goals as either hierarchical or compatible, the authors extend the BTOF's multiple-goal model to illuminate when firms pursue sociopolitical and financial goals as compatible (i.e. the activation rule) versus hierarchical (i.e. the sequential rule), thereby reconciling their tension in distinct performance situations. Practically, the authors provide fine-grained insights into how operations managers can prioritize multiple goals when making operational decisions. The authors' study also shows how policymakers can influence SOE operations to pursue sociopolitical goals for public benefit.
Assessing the effectiveness of Japan's ODA policy towards China: whether Japan has realized its national interests
Authors: Qin Qian 
Published: November 2023

PurposeThis research explores the intricate dynamics of national interests realised through Japan's official development assistance (ODA) to China. It aims to deepen the understanding of these mechanisms, detailing the extent to which Japan has accomplished its national interests.Design/methodology/approachThe paper applies the role theory and narrative analysis to elucidate Japan's national role conception and its categories of national interests with regards to its ODA policy. It utilises both qualitative and quantitative methods to examine the success rate in achieving Japan's diplomatic objectives and how those interests have manifested over time.FindingsThe findings suggest a mixed outcome. Whilst Japan's ODA to China has helped in expanding trade and fostering mutual understanding and cooperation, it has been less successful in promoting democratic governance in China or effectively counterbalancing China's regional power. Hence, the realisation of national interests through ODA is a complex process contingent upon numerous factors.Originality/valueThis study stands out for its multifaceted approach in examining Japan's ODA policy towards China, integrating both quantitative and qualitative methodologies and applying the role theory in the context of international development aid. It fills a significant gap in the literature by analysing the interplay between national interests and foreign aid, providing nuanced insights into the successes and challenges of Japan's pursuit of its diplomatic objectives. The study's findings have important implications for understanding the complexity of international aid dynamics and can inform future policy decisions in the realm of international relations and foreign aid.
Prospects and risks of digitalization in public relations research: mapping recurrent narratives of a debate in fragmentation (2010–2022)
Authors: Kretschmer Jannik , Winkler Peter 
Published: November 2023

PurposeThe debate on digitalization in the public relations (PR) literature has fragmented considerably over the past decade because of its focus on upcoming media-technological innovations, required professional skills and management concepts. Yet the field has difficulties in developing an integrative perspective on the implications of digitalization as a broader socio-technological transformation with a balanced consideration of prospects and risks.Design/methodology/approachThis paper proposes an integrative perspective that focuses more on the enduring imaginaries of how digitalization can transform society for better or worse. It traces the historical roots of five imaginaries of digitalization, which have already emerged over the past century yet have experienced a significant revival and popularization in the current debate. Based on these five imaginaries, the authors performed a narrative literature review of the digitalization debate in 10 leading PR journals from 2010 to 2022.FindingsThe five imaginaries allow for a systematization of the fragmented digitalization debate in the field, reconstructing recurrent narratives, prospects and risks.Originality/valueThe originality of this contribution lies in its reconstructive approach, tracing societal imaginaries of digitalization and their impact on the current disciplinary debate. This approach provides context for a balanced assessment of and engagement with upcoming, increasingly fragmented digital advancements in PR research and practice.
Measuring the integrated reporting quality in Europe: balanced scorecard perspectives
Authors: Nada Omar Hassan Ali , Győri Zsuzsanna 
Published: November 2023

Purpose
The aim of this study is to evaluate the adoption and quality of integrated reports in the European Union (EU).

Design/methodology/approach
The sample consists of 147 listed firms from the 18 EU countries during 2013–2020. This study creates a disclosure index – based on the balanced scorecard (BSC) that reflects the information content of integrated reports. The content analysis method is used to measure the integrated reporting quality (IRQ).

Findings
The findings demonstrate that the IRQ increased across the study’s time frame, going from 49.3% in 2013 to 77% in 2020. Furthermore, financial disclosures still get the most attention in the integrated reporting (IR), followed by learning and growth perspective disclosures. In addition, businesses in the financial and industrial sectors rely more on integrated reports. However, the utility sector has the highest IRQ score. By country, Spain has the highest rate of IR adoption, followed by France. Other countries, such as Austria and Hungary, have only implemented IR by one company each.

Research limitations/implications
This study adds to the IR literature a new approach to measure IRQ by linking BSC with the IR framework. Empirically, businesses of any size can use this method to assess the degree of balance between the revealed financial and nonfinancial information in their reports.

Practical implications
Empirically, this study helps IR practitioners in determining how widely IR is used in Europe and in updating the database on the IR website. It helps them update and improve the IR framework by identifying the elements that have the least transparency and quality, investigating the causes and enhancing them.

Originality/value
To the best of the authors’ knowledge, this study is the first to examine the IRQ in EU countries by linking the BSC with IR elements. This is to split the elements into their own pillars, making it easier to track disclosure and evaluate the corporations’ interest in revealing these perspectives, on their own and collectively.