bluuebunny/crossref_metadata_2025_split huggingface dataset:
Current status of stem cell therapy for type 1 diabetes: a critique and a prospective consideration
Authors: Ghoneim Mohamed A. , Gabr Mahmoud M. , El-Halawani Sawsan M. , Refaie Ayman F. 
Published: January 2024

AbstractOver the past decade, there had been progress in the development of cell therapy for insulin-dependent diabetes. Nevertheless, important hurdles that need to be overcome still remain. Protocols for the differentiation of pluripotent stem cells into pancreatic progenitors or fully differentiated β-cells have been developed. The resulting insulin-producing cells can control chemically induced diabetes in rodents and were the subject of several clinical trials. However, these cells are immunogenic and possibly teratogenic for their transplantation, and an immunoisolation device and/or immunosuppression is needed. A growing number of studies have utilized genetic manipulations to produce immune evasive cells. Evidence must be provided that in addition to the expected benefit, gene manipulations should not lead to any unforeseen complications. Mesenchymal stem/stromal cells (MSCs) can provide a viable alternative. MSCs are widely available from many tissues. They can form insulin-producing cells by directed differentiation. Experimentally, evidence has shown that the transplantation of allogenic insulin-producing cells derived from MSCs is associated with a muted allogeneic response that does not interfere with their functionality. This can be explained by the immunomodulatory functions of the MSC subpopulation that did not differentiate into insulin-producing cells. Recently, exosomes derived from naive MSCs have been used in the experimental domain to treat diabetes in rodents with varying degrees of success. Several mechanisms for their beneficial functions were proposed including a reduction in insulin resistance, the promotion of autophagy, and an increase in the T regulatory population. However, euglycemia was not achieved in any of these experiments. We suggest that exosomes derived from β-cells or insulin-producing cells (educated) can provide a better therapeutic effect than those derived from undifferentiated cells.
Sex differences in the effects of repeated ketamine infusions on bone markers in patients with unipolar and bipolar depression
Authors: Lan Xiaofeng , Liu Haiyan , Wang Chengyu , Li Weicheng , Zhang Fan , Hu Zhibo , Chen Xiaoyu , You Zerui , Ning Yuping , Zhou Yanling 
Published: January 2024

Abstract
Background
Patients with depression, especially women, are associated with low bone mineral density (BMD). Traditional antidepressants are associated with negative effects on BMD. Few studies have examined the effect of ketamine on BMD, and it remains unclear whether there are sex differences in the effects of ketamine on BMD in patients with depression.

Methods
A total of 102 patients with unipolar and bipolar depression were administered six infusions of intravenous ketamine over a 12-day period. Plasma levels of eight bone markers were examined at baseline, 24 h after the sixth infusion and again 2 weeks (Days 13 and 26).

Results
Linear mixed models showed all bone markers had significant time main effect (all p < 0.05). Compared with baseline, the whole sample showed increased levels of leptin and osteoprotegerin at Days 13 and 26, as well as Dickkopf-related protein 1 at Day 13, and decreased levels of osteocalcin, sclerostin, osteopontin, parathyroid hormone and fibroblast growth factor 23 at Days 13 and 26 (all p < 0.05). Females had a higher level of leptin at Days 13 and 26, and lower levels of osteocalcin and sclerostin at Day 13 than males (all p < 0.05). Increases of leptin were associated with depressive symptom improvements at Day 13 and Day 26 in females (both p < 0.05). In males, higher baseline osteocalcin levels were associated with greater depressive symptom improvement at Day 26 (β = 0.414, p = 0.009).

Conclusions
Our results suggest that repeated ketamine infusions may be associated with modulation of bone markers in patients with depression and present sex differences. Baseline osteocalcin level may be served as a predictor for the antidepressant effects of ketamine in males.
Trial registration Data were derived from an open label clinical trial, which was registered at Chinese Clinical Trial Registry (ChiCTR-OOC-17012239). Registered 26 May 2017. http://www.chictr.org.cn
Covid-19-associated pulmonary aspergillosis in mechanically ventilated patients: incidence and outcome in a French multicenter observational cohort (APICOVID)
Authors: Desmedt Luc , Raymond Matthieu , Le Thuaut Aurélie , Asfar Pierre , Darreau Cédric , Reizine Florian , Colin Gwenhaël , Auchabie Johann , Lorber Julien , La Combe Béatrice , Kergoat Pierre , Hourmant Baptiste , Delbove Agathe , Frérou Aurélien , Morin Jean , Ergreteau Pierre Yves , Seguin Philippe , Martin Maëlle , Reignier Jean , Lascarrou Jean-Baptiste , Canet Emmanuel 
Published: January 2024

Abstract
Background
Recent studies identified coronavirus disease 2019 (COVID-19) as a risk factor for invasive pulmonary aspergillosis (IPA) but produced conflicting data on IPA incidence and impact on patient outcomes. We aimed to determine the incidence and outcomes of COVID-19-associated pulmonary aspergillosis (CAPA) in mechanically ventilated patients.

Methods
We performed a multicenter retrospective observational cohort study in consecutive adults admitted to 15 French intensive care units (ICUs) in 2020 for COVID-19 requiring mechanical ventilation. CAPA was diagnosed and graded according to 2020 ECMM/ISHAM consensus criteria. The primary objective was to determine the incidence of proven/probable CAPA, and the secondary objectives were to identify risk factors for proven/probable CAPA and to assess associations between proven/probable CAPA and patient outcomes.

Results
The 708 included patients (522 [73.7%] men) had a mean age of 65.2 ± 10.8 years, a median mechanical ventilation duration of 15.0 [8.0–27.0] days, and a day-90 mortality rate of 28.5%. Underlying immunosuppression was present in 113 (16.0%) patients. Corticosteroids were used in 348 (63.1%) patients. Criteria for probable CAPA were met by 18 (2.5%) patients; no patient had histologically proven CAPA. Older age was the only factor significantly associated with probable CAPA (hazard ratio [HR], 1.04; 95% CI 1.00–1.09; P = 0.04). Probable CAPA was associated with significantly higher day-90 mortality (HR, 2.07; 95% CI 1.32–3.25; P = 0.001) but not with longer mechanical ventilation or ICU length of stay.

Conclusion
Probable CAPA is a rare but serious complication of severe COVID-19 requiring mechanical ventilation and is associated with higher day-90 mortality.

Graphical Abstract
Cancer metabolism and carcinogenesis
Authors: Yang Jianqiang , Shay Chloe , Saba Nabil F. , Teng Yong 
Published: January 2024

AbstractMetabolic reprogramming is an emerging hallmark of cancer cells, enabling them to meet increased nutrient and energy demands while withstanding the challenging microenvironment. Cancer cells can switch their metabolic pathways, allowing them to adapt to different microenvironments and therapeutic interventions. This refers to metabolic heterogeneity, in which different cell populations use different metabolic pathways to sustain their survival and proliferation and impact their response to conventional cancer therapies. Thus, targeting cancer metabolic heterogeneity represents an innovative therapeutic avenue with the potential to overcome treatment resistance and improve therapeutic outcomes. This review discusses the metabolic patterns of different cancer cell populations and developmental stages, summarizes the molecular mechanisms involved in the intricate interactions within cancer metabolism, and highlights the clinical potential of targeting metabolic vulnerabilities as a promising therapeutic regimen. We aim to unravel the complex of metabolic characteristics and develop personalized treatment approaches to address distinct metabolic traits, ultimately enhancing patient outcomes.
A genomics perspective of personalized prevention and management of obesity
Authors: Gkouskou Kalliopi K. , Grammatikopoulou Maria G. , Lazou Evgenia , Vasilogiannakopoulou Theodora , Sanoudou Despina , Eliopoulos Aristides G. 
Published: January 2024

AbstractThis review discusses the landscape of personalized prevention and management of obesity from a nutrigenetics perspective. Focusing on macronutrient tailoring, we discuss the impact of genetic variation on responses to carbohydrate, lipid, protein, and fiber consumption. Our bioinformatic analysis of genomic variants guiding macronutrient intake revealed enrichment of pathways associated with circadian rhythm, melatonin metabolism, cholesterol and lipoprotein remodeling and PPAR signaling as potential targets of macronutrients for the management of obesity in relevant genetic backgrounds. Notably, our data-based in silico predictions suggest the potential of repurposing the SYK inhibitor fostamatinib for obesity treatment in relevant genetic profiles. In addition to dietary considerations, we address genetic variations guiding lifestyle changes in weight management, including exercise and chrononutrition. Finally, we emphasize the need for a refined understanding and expanded research into the complex genetic landscape underlying obesity and its management.
Avoidant/restrictive food intake disorder differs from anorexia nervosa in delay discounting
Authors: Stern Casey M. , McPherson Iman , Dreier Melissa J. , Coniglio Kathryn , Palmer Lilian P. , Gydus Julia , Graver Haley , Germine Laura T. , Tabri Nassim , Wang Shirley B. , Breithaupt Lauren , Eddy Kamryn T. , Thomas Jennifer J. , Plessow Franziska , Becker Kendra R. 
Published: January 2024

Abstract
Background
Avoidant/restrictive food intake disorder (ARFID) and anorexia nervosa (AN) are the two primary restrictive eating disorders; however, they are driven by differing motives for inadequate dietary intake. Despite overlap in restrictive eating behaviors and subsequent malnutrition, it remains unknown if ARFID and AN also share commonalities in their cognitive profiles, with cognitive alterations being a key identifier of AN. Discounting the present value of future outcomes with increasing delay to their expected receipt represents a core cognitive process guiding human decision-making. A hallmark cognitive characteristic of individuals with AN (vs. healthy controls [HC]) is reduced discounting of future outcomes, resulting in reduced impulsivity and higher likelihood of favoring delayed gratification. Whether individuals with ARFID display a similar reduction in delay discounting as those with AN (vs. an opposing bias towards increased delay discounting or no bias) is important in informing transdiagnostic versus disorder-specific cognitive characteristics and optimizing future intervention strategies.

Method
To address this research question, 104 participants (ARFID: n = 57, AN: n = 28, HC: n = 19) completed a computerized Delay Discounting Task. Groups were compared by their delay discounting parameter (ln)k.

Results
Individuals with ARFID displayed a larger delay discounting parameter than those with AN, indicating steeper delay discounting (M ± SD = −6.10 ± 2.00 vs. −7.26 ± 1.73, p = 0.026 [age-adjusted], Hedges’ g = 0.59), with no difference from HC (p = 0.514, Hedges’ g = −0.35).

Conclusion
Our findings provide a first indication of distinct cognitive profiles among the two primary restrictive eating disorders. The present results, together with future research spanning additional cognitive domains and including larger and more diverse samples of individuals with ARFID (vs. AN), will contribute to identifying maintenance mechanisms that are unique to each disorder as well as contribute to the optimization and tailoring of treatment strategies across the spectrum of restrictive eating disorders.
Is the Common Test for University Admissions in Japan enough to measure students’ general English proficiency? The case of the TOEIC Bridge
Authors: Kamiya Nobuhiro 
Published: January 2024

AbstractThis study investigated to what extent the scores of two English tests are correlated to each other, namely, the English test of the Common Test for University Admissions (Common Test, henceforth) in Japan and the TOEIC Bridge, a commercially available English test developed by Educational Testing Service (ETS) that measures four skills of listening, reading, speaking, and writing. Moreover, this study examined to what extent the two tests’ constructs overlap from the viewpoint of L2 competence. In total, 128 university freshmen and high school seniors took the Common Test at the official venues and also the TOEIC Bridge at the researcher’s university (n = 92) or at home (n = 36) a few months later. Results indicated that the scores of the corresponding skills are moderately correlated to each other across the two tests (Reading = .548; Listening = .646; Total = .732). Confirmatory factor analyses demonstrated that the degree of data fitting of the three models of test constructs (unitary, correlated skills, correlated tests) was statistically similar to each other. On the basis of substantive and statistical results, however, we claim that the correlated skills model should be chosen as the best-fit model and, consequently, that the productive skills should be measured in addition to the Common Test.
Formation techniques for upper active channel in monolithic 3D integration: an overview
Authors: Nguyen An Hoang-Thuy , Nguyen Manh-Cuong , Nguyen Anh-Duy , Jeon Seung Joon , Park Noh-Hwal , Lee Jeong-Hwan , Choi Rino 
Published: January 2024

AbstractThe concept of three-dimensional stacking of device layers has attracted significant attention with the increasing difficulty in scaling down devices. Monolithic 3D (M3D) integration provides a notable benefit in achieving a higher connection density between upper and lower device layers than through-via-silicon. Nevertheless, the practical implementation of M3D integration into commercial production faces several technological challenges. Developing an upper active channel layer for device fabrication is the primary challenge in M3D integration. The difficulty arises from the thermal budget limitation for the upper channel process because a high thermal budget process may degrade the device layers below. This paper provides an overview of the potential technologies for forming active channel layers in the upper device layers of M3D integration, particularly for complementary metal-oxide-semiconductor devices and digital circuits. Techniques are for polysilicon, single crystal silicon, and alternative channels, which can solve the temperature issue for the top layer process.
Can training and apprentice programs in STEM increase worker life satisfaction and optimism?
Authors: Chun Yung , Jabbari Jason , Huang Wenrui , Graham Carol 
Published: January 2024

Abstract
Background
Despite the significant relationship between life satisfaction and education, less is known about the connection between life satisfaction and informal learning in the context of training and apprenticeship programs. This paper examines the influence of the LaunchCode program, a novel training and apprentice program in STEM, on participant’s life satisfaction and optimism. We also explore mediating roles of STEM employment and earnings, as well as moderating role of participants’ educational attainment levels.

Results
We find high life satisfaction and optimism among those who completed both the training course and the apprenticeship component. In addition, we find a significant mediation effect of STEM employment on the relationships between program participation and current life satisfaction, as well as optimism, among the apprenticeship completers. Finally, we find a significant moderation effect of one’s education level on the relationship between program completion and finding a STEM job, such that participants with a college degree are more likely to secure STEM employment through coursework alone.

Conclusions
Our findings highlight the significance of apprenticeships in increasing life satisfaction and optimism, as well as the importance of STEM employment in explaining the significant effect of apprenticeships on life satisfaction and optimism. These findings suggest that what people do for a living is more important than how much they earn. However, while apprenticeships may offer an alternative route to the labor market, education may still facilitate connections to STEM employment in the absence of an apprenticeship.
Variation of crater morphological parameters in the landing area of Tianwen-1: relationships with the geological environment and climate change
Authors: Yang Yu , Wang Yi , Li Bo , Ling Zongcheng , Liu Yang , Qu Shaojie , Chen Shengbo 
Published: January 2024

AbstractThe Zhurong rover of the Tianwen-1 mission successfully landed in the southern part of the Utopian Planitia and the northern region of the dichotomy boundary. Craters within a ~ 134 km2 region surrounding the Zhurong rover were identified and divided into seven degradation classes based on their preservation states and morphological details. Assessing how craters have degraded over time provides insight into local surface processes and then speculates on the climate evolution of the study area. The small depth/diameter (d/D) of craters in the study area may be caused by the rapid filling of sediments or by impact processes occurring in poorly cohesive weathering layers, and may also be associated with the volatile material alteration. As time went by, the process of crater degradation is nonlinear, and the degradation rate of the fresh crater in the study area at the initial stage of degradation may be as high as 0.2 m/Myr. The calculated surface erosion rate for the study area is ~ 10–2–10–3 m/Myr, indicating that the erosion of the Martian surface since the Middle Amazonian occurred in the dry environment dominated by wind-sand erosion.
Graphical Abstract
Recombinant antithrombin attenuates acute kidney injury associated with rhabdomyolysis: an in vivo animal study
Authors: Miura Tomotaka , Okuda Tomoki , Suzuki Kodai , Okada Hideshi , Tomita Hiroyuki , Takada Chihiro , Mori Kosuke , Asano Hirotaka , Kano Soichiro , Wakayama Yugo , Fukuda Yohei , Fukuda Hirotsugu , Nishio Ayane , Kawasaki Yuki , Kuroda Ayumi , Suzuki Keiko , Kamidani Ryo , Okamoto Haruka , Fukuta Tetsuya , Kitagawa Yuichiro , Miyake Takahito , Nakane Keita , Suzuki Akio , Yoshida Takahiro , Tetsuka Nobuyuki , Yoshida Shozo , Koie Takuya , Ogura Shinji 
Published: January 2024

Abstract
Background
Rhabdomyolysis is characterized by the destruction and necrosis of skeletal muscle tissue, resulting in acute kidney injury (AKI). Recombinant antithrombin (rAT) has DNA repair and vascular endothelial-protection properties. Herein, we investigated whether rAT therapy has beneficial effects against rhabdomyolysis-induced AKI. Ten-week-old male B6 mice were injected with 5 mL/kg of 50% glycerol intramuscularly in the left thigh after 24 h of fasting to create a rhabdomyolysis mouse model. Further, 750 IU/kg rAT was injected intraperitoneally at 24 and 72 h after the rhabdomyolysis model was established. The mice were euthanized after 96 h for histological analysis. Saline was administered to mice in the control group.

Results
Blood tests show elevated serum creatinine, urea nitrogen, and neutrophil gelatinase-associated lipocalin levels in rhabdomyolysis. Loss of tubular epithelial cell nuclei and destruction of the tubular luminal surface structure was observed in the untreated group, which improved with rAT treatment. Immunostaining for Ki-67 showed increased Ki-67-positive nuclei in the tubular epithelial cells in the rAT group, suggesting that rAT may promote tubular epithelial cell regeneration. The microvilli of the brush border of the renal tubules were shed during rhabdomyolysis, and rAT treatment reduced this injury. The vascular endothelial glycocalyx, which is usually impaired by rhabdomyolysis, became functional following rAT treatment.

Conclusions
Treatment with rAT suppressed rhabdomyolysis-induced AKI, suggesting that rAT therapy may be a novel therapeutic approach.
Unsupervised generation of fashion editorials using deep generative model
Authors: Kang Minjoo , Kim Jongsun , Kim Sungmin 
Published: January 2024

AbstractThis research intended to establish a new fashion-related artificial intelligence research topic concerning fashion editorials which could induce streams of further studies. A new fashion editorial dataset, which is a prerequisite in training an AI model, has been established in this study to meet the research purpose. A total of over 150K fashion editorials were initially collected and processed to satisfy necessary dataset conditions. A novel dataset of fashion editorials consisting of approximately 60K editorials is proposed through the process. In order to prove the adequacy of the new dataset, data distribution was analyzed and a generative model was selected and trained to attest that new fashion editorials can be created with the proposed editorial dataset. The results generated by the trained model were qualitatively investigated. The model has shown to have learned various features that compose editorials with the dataset, successfully generating fashion editorials. Quantitative evaluation with FID scores was conducted to support the selection of the generative model used for the qualitative assessment.
Duodenal neuroendocrine tumor after bilateral breast cancer with type 1 neurofibromatosis: a case report
Authors: Fujiwara Sho , Koyamada Nozomi , Miyazawa Koji , Saiki Yuriko , Horii Akira , Miyazaki Shukichi 
Published: January 2024

Abstract
Background
Young women with NF1 are at a high risk of developing breast cancer. Although they are at risk for abdominal tumors, such as gastrointestinal stromal tumors and neuroendocrine tumors, follow-up strategies for other tumors after breast cancer have not yet been established. Here, we present a case of duodenal neuroendocrine tumor found during follow-up after bilateral mastectomy for breast cancer with type 1 neurofibromatosis (NF1), for which pancreaticoduodenectomy (PD) and lymphadenectomy were performed.

Case presentation
A 46-year-old woman with NF1 was referred to our hospital for treatment of a duodenal submucosal tumor. Her previous operative history included bilateral mastectomy for breast cancer: right total mastectomy and left partial mastectomy performed 9 and 5 years ago, respectively. Her daughter was confirmed to have NF1, but her parents were unclear. Although she had no recurrence or symptoms during the follow-up for her breast cancer, she wished to undergo 18-fluorodeoxyglucose–positron emission tomography (FDG–PET) for systemic screening. FDG–PET demonstrated FDG accumulation in the duodenal tumor with a maximum standardized uptake value of 5.78. Endoscopy revealed a 20-mm-diameter tumor in the second duodenal portion, and endoscopic biopsy suggested a NET G1. We performed PD and lymphadenectomy for complete. She was doing well without recurrence and was followed up with PET tomography–computed tomography.

Conclusions
Early detection of gastrointestinal tumors is difficult, because most of them are asymptomatic. Gastrointestinal screening is important for patients with NF1, and PD with lymphadenectomy is feasible for managing duodenal neuroendocrine tumors, depending on their size.