bluuebunny/crossref_metadata_2025_split huggingface dataset:
Microbial spectrum, patient-specific factors, and diagnostics in implant-related postoperative spondylodiscitis
Authors: Pichler Lorenz , Li Zhao , Khakzad Thilo , Perka Carsten , Pumberger Matthias , Schömig Friederike 
Published: November 2023

AimsImplant-related postoperative spondylodiscitis (IPOS) is a severe complication in spine surgery and is associated with high morbidity and mortality. With growing knowledge in the field of periprosthetic joint infection (PJI), equivalent investigations towards the management of implant-related infections of the spine are indispensable. To our knowledge, this study provides the largest description of cases of IPOS to date.MethodsPatients treated for IPOS from January 2006 to December 2020 were included. Patient demographics, parameters upon admission and discharge, radiological imaging, and microbiological results were retrieved from medical records. CT and MRI were analyzed for epidural, paravertebral, and intervertebral abscess formation, vertebral destruction, and endplate involvement. Pathogens were identified by CT-guided or intraoperative biopsy, intraoperative tissue sampling, or implant sonication.ResultsA total of 32 cases of IPOS with a mean patient age of 68.7 years (37.6 to 84.1) were included. Diabetes, age > 60 years, and history of infection were identified as risk factors. Patient presentation upon admission included a mean body temperature of 36.7°C (36.1 to 38.0), back pain at rest (mean visual analogue scale (VAS) mean 5/10) and when mobile (mean VAS 6/10), as well as elevated levels of CRP (mean 76.8 mg/l (0.4 to 202.9)) and white blood cell count (mean 9.2 units/nl (2.6 to 32.8)). Pathogens were identified by CT-guided or conventional biopsy, intraoperative tissue sampling, or sonication, and Gram-positive cocci presented as the most common among them. Antibiotic therapy was established in all cases with pathogen-specific treatment in 23 (71.9%) subjects. Overall 27 (84.4%) patients received treatment by debridement, decompression, and fusion of the affected segment.ConclusionCases of IPOS are rare and share similarities with spontaneous spondylodiscitis. While procedures such as CT-guided biopsy and sonication are valuable tools in the diagnosis of IPOS, MRI and intraoperative tissue sampling remain the gold standard. Research on known principles of PJI such as implant retention versus implant exchange need to be expanded to the field of spine surgery.Cite this article: Bone Jt Open 2023;4(11):832–838.
Least-squares method constrained by phase smoothness for correcting illumination fluctuation errors in phase-shifting profilometry: erratum
Authors: Zhu Huijie , Guo Hongwei 
Published: November 2023

This erratum corrects an error in Eq. (29) of the original paper, Appl. Opt. 62, 8451 (2023)APOPAI0003-693510.1364/AO.505327.
Building a digital twin for large-scale and dynamic C+L-band optical networks
Authors: Zhang Yao , Zhang Min , Song Yuchen , Shi Yan , Zhang Chunyu , Ju Cheng , Guo Bingli , Huang Shanguo , Wang Danshi 
Published: November 2023

Bridging the gap between the real and virtual worlds, a digital twin (DT) leverages data, models, and algorithms for comprehensive connectivity. The research on DTs in optical networks has increased in recent years; however, optical networks are evolving toward wideband capabilities, highly dynamic states, and ever-increasing scales, posing huge challenges, including high complexity, extensive computational duration, and limited accuracy for DT modeling. In this study, the DT models are developed based on the Gaussian noise (GN) model and a deep neural network (DNN) to perform efficient and accurate quality of transmission estimations in large-scale C+L-band optical networks, facilitating effective management and control in the digital platform. The DNN-based model obtained the estimated generalized signal-to-noise absolute errors within 0.2 dB in large-scale network simulation, specifically a 77-node network topology. Additionally, compared to the GN-based model, the testing time by using the DNN-based model has been significantly reduced from tens of minutes to 110 ms. Moreover, based on the DT models, multiple potential application scenarios are studied to ensure high-reliability operation and high-efficiency management, including optimization and control of physical layer devices, real-time responses to deterioration alarms and link faults, and network rerouting and resource reallocation. The constructed DT framework integrates practical analysis and deduction functions, with fast operation and accurate calculation to gradually promote the efficient design of optical networks.
Serum cytokines MCP-1 and GCS-F as potential biomarkers in pediatric inflammatory bowel disease
Authors: Ott Andrea , Tutdibi Erol , Goedicke-Fritz Sybelle , Schöpe Jakob , Zemlin Michael , Nourkami-Tutdibi Nasenien 
Published: November 2023

Background
Inflammatory bowel diseases (IBDs) with the subtypes ulcerative colitis (UC) and Crohn disease (CD), are chronic autoimmune inflammatory disorders of the gastrointestinal tract. Cytokines are associated with the development and progression in pediatric IBD. We measured cytokine levels in pediatric IBD patients to assess their potential function as biomarkers in disease assessment.

Method
In this prospective cohort study, we enrolled 33 children with IBD. All patients were in stable remission for 3 months on enrollment. Patients who developed a relapse within six months after enrollment were classified as relapsers. Blood sampling was performed at enrolment and for relapsers in relapse and post-relapse. Serum concentrations of 14 cytokines, chemokines and growth factors (IL-1α, IL-1β, IL-6, IL-12p40, IP-10, TNF-α, IFN-γ, IL-10, IL-8, MIP-1α, MCP-1, MCP-3, G-CSF, GM-CSF) were measured simultaneously using multiplex bead-based sandwich immunoassay on Luminex 100 system.

Results
MCP-1 was significantly higher in CD patients compared to UC patients at each disease stage: stable remission (P<0.048), unstable remission (P<0.013), relapse (P<0.026) and post-relapse (P<0.024). G-CSF was significantly increased in UC patients developing a relapse and in post-relapse stage compared to UC patients in remission (P<0.02 and p<0.03, respectively).

Conclusion
MCP-1 showed potential as a diagnostic biomarker in CD patients independent of disease activity as it was able to discriminate between subtypes of pediatric IBD. In UC patients, G-CSF was significantly elevated in relapsers indicating its use and role as a potential prognostic biomarker.
Political and Sartorial Styles: Britain and Its Colonies in the Long Nineteenth Century, Kevin A. Morrison (ed.) (2023)
Authors: Matheson Linda Florence 
Published: November 2023

Review of: Political and Sartorial Styles: Britain and Its Colonies in the Long Nineteenth Century, Kevin A. Morrison (ed.) (2023)
Manchester: Manchester University Press, 274 pp.,
ISBN 978-1-52615-307-4, h/bk, $195.00
ISBN 978-1-52615-306-7, e-book, $135.00
Fear and Clothing: Dress in English Detective Fiction between the First and Second World Wars, Jane Custance Baker (2023)
Authors: Adomaitis Alyssa Dana 
Published: November 2023

Review of: Fear and Clothing: Dress in English Detective Fiction between the First and Second World Wars, Jane Custance Baker (2023)
London: Bloomsbury Publishing, 252 pp.,
ISBN 978-1-35024-030-8, h/bk, $82.80
Enhanced apoptotic activity of Pluronic F127 polymer-encapsulated chlorogenic acid nanoparticles through the PI3K/Akt/mTOR signaling pathway in liver cancer cells and in vivo toxicity studies in zebrafish
Authors: Alanazi Fehaid , Elderdery Abozer Y. , Alzahrani Badr , Alzerwi Nasser A. N. , Althobiti Maryam Musleh , Rayzah Musaed , Alanazi Abdulaziz Suailem , Kuriri Fahd A. , Idrees Bandar , Alenazy Fawaz O. , Alsultan Afnan , Rayzah Fares , Baksh Yaser , Subbiah Suresh Kumar , Mok Pooi Ling 
Published: November 2023

Abstract
In this study, chlorogenic acid nanoparticles encapsulated in Pluronic F127 polymer were synthesized and characterized to determine if they could treat human liver cancer. The nanoparticles were synthesized using standard procedures and characterized using physical and biological techniques such as X-ray diffraction, Fourier transform infrared spectroscopy, UV-Vis, dynamic light scattering, Photoluminescence, scanning electron microscopy, and transmission electron microscopy. The anticancer effects were assessed using MTT analysis, acridine orange/ethidium bromide, reactive oxygen species (ROS), COMET assay, annexin-V/FITC, cell cycle analysis, and expression of marker genes against HepG2 cell lines. The results showed significant cytotoxicity, apoptosis induction, and increased ROS production in treated cells compared to control cells. The nanoparticles also activated the apoptotic cascade and regulated the PI3K/AKT/mTOR pathways. The nanocomposites exhibited unique characteristics such as anticancer efficacy in vitro. Further research was conducted using zebrafish to model hematological parameters, liver enzymes, and histopathology to study effectiveness. Green-synthesized Pluronic F127–chlorogenic acid nanoparticles can be considered potential cancer therapy agents.
TheAtoh1-CreKnock-In Allele Ectopically Labels a Subpopulation of Amacrine Cells and Bipolar Cells in Mouse Retina
Authors: Wu Sih-Rong , Zoghbi Huda Y. 
Published: November 2023

AbstractThe retina has diverse neuronal cell types derived from a common pool of retinal progenitors. Many molecular drivers, mostly transcription factors, have been identified to promote different cell fates. InDrosophila,atonalis required for specifying photoreceptors. In mice, there are two closely relatedatonalhomologs,Atoh1andAtoh7. WhileAtoh7is known to promote the genesis of retinal ganglion cells, there is no study on the function ofAtoh1in retinal development. Here, we crossedAtoh1Cre/+mice to mice carrying a Cre-dependent TdTomato reporter to track potentialAtoh1-lineage neurons in retinas. We characterized a heterogeneous group of TdTomato+retinal neurons that were detected at the postnatal stage, including glutamatergic amacrine cells, AII amacrine cells, and BC3b bipolar cells. Unexpectedly, we did not observe TdTomato+retinal neurons in the mice with anAtoh1-FlpOknock-in allele and a Flp-dependent TdTomato reporter, suggestingAtoh1is not expressed in the mouse retina. Consistent with these data, conditional removal ofAtoh1in the retina did not cause any observable phenotypes. Importantly, we did not detectAtoh1expression in the retina at multiple ages using mice withAtoh1-GFPknock-in allele. Therefore, we conclude thatAtoh1Cre/+mice have ectopic Cre expression in the retina and thatAtoh1is not required for retinal development.
Soil Fertility Detection and Crop Prediction using IoT and Machine Learning
Authors: Chaudhari Bhushan , Kamble Sachin , Patil Madhuri , Bhosale Gayatri , Jagtap Kavita , Patil Gaurav , Wakalkar Priyanka 
Published: November 2023

India has huge agriculture heritage. This is the major source of livelihood for most Indian families. Farmers are seen to use fertilizers in inappropriate proportion to enhance crop yield which results in infertile land. To overcome this issue, to check the fertility level of the soil, environment conditions and predicting suitable crop and fertilizers required is need of hour. Soil fertility depends on nutrients like Nitrogen (N), Phosphorous (P), and Potassium (K). It is also affected by environmental factors such as temperature, moisture, humidity, etc. The proposed system provides a cost-effective solution using IoT and Machine Learning based approach to check the NPK concentration present in the soil. Based on which, user can predict the soil suitable crop. The technique used comprises an integrated light transmission and detection system which consists of three LEDs with different wavelengths. Photodiode (LDR sensor module) is used for light detection purposes. The output obtained from the photodiode is handled using a Arduino UNO microcontroller. Based on the inputs received from LDR module, NPK concentration can be evaluated. The model is trained with the Crop Prediction dataset to predict the crop using LightGBM algorithm. The proportion of NPK nutrients and the predicted crop is sent to the user as a text message through the GSM module and ThingSpeak cloud platform.
Heterodoxo, ser emergente
Authors: Rojas Vergara Emma Del Pilar 
Published: November 2023

El sentido de relatividad, de cambio y transformación evolutiva del ser humano y de su inteligencia creativa lo convierten en el heterodoxo cósmico de carácter emergente. El presente artículo pretende comprender a ese hombre así caracterizado en la raíz de su naturaleza como alguien que vive dentro de una estructura ordenada, sin olvidar que está lanzado a la fugacidad y transitoriedad en el cosmos en donde a la vez se siente pasajero y emergente. Tal grado de conciencia de sí mismo y de los otros, advierte al hombre que la vida es valiosa y contiene en su esencia el sentido para ser vivida en conexión con todo cuanto existe.
Situar al hombre en una realidad emergente, siendo capaz de tener conciencia de sí mismo y de los otros, significa reconocer que se dan orígenes comunes en el cosmos con los que mantiene estrecha comunicación a pesar de la disparidad y la no coincidencia. Armonía, diálogo y comprensión permitirán que la vida sea llevadera y se convierta en arte en la búsqueda de pequeñas y grandes satisfacciones. El artículo está propuesto para volver la atención hacia esta experiencia enteramente humana.
Formación axiológica para el desarrollo de las sociedades actuales
Authors: Cabrera Benavides Lucero Liliana 
Published: November 2023

A través del tiempo los seres humanos han tenido la necesidad de organizarse en un determinado territorio, para ello las comunidades han formado jerarquías y reglas que mantienen la subsistencia humana. Estas condiciones, igualmente, han generado diferentes problemas dada la superación de límites de poder, lo cual en muchos casos ha llevado a situaciones extremas, como las guerras mundiales que han incidido en la formación de las sociedades actuales.
In Vitro Antibacterial Activity of Flower Extract of Leucas Indica
Authors: M. Sowjanya  , Ch. Venkatrayulu  , B.V. Sandeep  , Vardi Venkateswarlu  
Published: November 2023

İn this study, the antimicrobial activities of methanol extracts of flowers of Leucas indica was investigated by using agar well diffusion method against selected ten bacterial species (Pseudomonas (MTCC 424), Corynebacterium (MTCC 1349), Spingomonas (MTCC 6362), Bacillus subtilis (MTCC 441), Bacillus licheniformis (MTCC 429), Bacillus coagulans (MTCC 5856), Streptococcus (MTCC 9724), Klebsiella pneumonia (MTCC 452), E. coli (MTCC 443), and Staphyloccus (MTCC 3160). Among the ten bacterial species studied, the flower extract at concentrations of 20µg and 40µg showed antimicrobial activity against Klebsiella pneumonia, E. coli, Streptococcus, Bacillus subtilis, Spingomonas, Staphyloccus and Corynebacterium respectively.
Reappraising the 25 February 1695 Asolano Earthquake
Authors: Camassi Romano , Castelli Viviana , Serpelloni Enrico , Pondrelli Silvia 
Published: November 2023

Abstract
The 1695 Mw 6.4 Asolano earthquake is the southernmost of the six largest earthquakes to have occurred in northeast Italy or nearby (the others being 1348 Mw 6.6 Eastern Alps; 1511 Mw 6.3 Friuli-Slovenia; 1873 Mw 6.2 Alpago-Cansiglio; 1936 Mw 6.1 Alpago-Cansiglio; 1976 Mw 6.4 Friuli). The 1695 earthquake is generally associated with the Montello thrust, with most recent studies locating it on the eastern slope of Montello Hill. A full-scale reappraisal of all available historical data leads this study to a more robust macroseismic localization of the 1695 earthquake and to open toward other possible locations of the seismic source that produced it. In particular, it becomes feasible to place its epicenter at the foothills of the Monte Grappa massif, the major morphological expression of the Bassano–Valdobbiadene thrust fault. Here, we describe the reasons that make this fault a possible alternative to previous hypotheses.
Exhumation History of the Greater Khingan Mountains (NE China) Since the Late Mesozoic: Implications for the Tectonic Regime Change of Northeast Asia
Authors: Wang Hongtao , Li Shichao , Zhang Lingyu , Sheldrick Thomas C. , Liu Fangbin , Zhao Zheren , Yang Xiaopeng , Wang Yadong 
Published: November 2023

Abstract
The Greater Khingan Mountains (GKMs) are a prominent orogenic zone in Northeast Asia that offers significant insights into the evolution of the Mongol-Okhotsk Ocean and the Pacific Ocean during the Phanerozoic. A comprehensive study integrating a low-temperature thermochronology analysis pertaining to the Greater Khingan area and its associated basins has been conducted. Apatite fission-track (AFT) tests conducted on detrital samples from the GKMs in Northeast China have yielded central ages ranging from 260 to 62 Ma. Two-dimensional thermal history inversion modeling and three-dimensional numerical simulations were used to investigate the GKMs' thermal history, revealing at least two distinct tectonic cooling and exhumation events: one occurring between 147 and 70 Ma and another around 35 Ma. The fission-track age groups of the GKMs, Hailar-Erlian Basin, and Mohe Basin bear some resemblance (&gt;105 Ma), but the results from the Songliao Basin are unique. This implies that the Songliao Basin and the GKMs were likely under the influence of different tectonic domains during this period, while AFT age peaks between 105 and 45 Ma, indicating the basin-mountain systems were likely influenced by a unified Paleo-Pacific plate process, which prevailed from about 105 Ma. The 147–70 Ma cooling event can be attributed to the combined effects of the compression orogeny, resulting from the closure of the Mongol-Okhotsk Ocean during the Early Cretaceous and the extension orogeny triggered by the subduction of the Paleo-Pacific Ocean during the early Late Cretaceous. Since approximately 35 Ma, the increase in Pacific plate subduction speed may have established a post-arc extensional tectonic environment in the GKMs that has persisted until now.
The fractional analysis of thermo-elasticity coupled systems with non-linear and singular nature
Authors: Rab Abdur , Khan Shahbaz , Khan Hassan , Tchier Fairouz , Tawfiq Ferdous , Nadeem Muhammad , Jebran Samaruddin 
Published: November 2023

Abstract

It is noted that the study of linear and non-linear thermo-elasticity systems has a key role inthermal conductivity, stresses, as well as elasticity, and temperature. The solution to these systemsis one of the important parts of the present research. The fractional form of various thermo-elasticsystems is discussed, and their solutions are attained in a sophisticated manner. The solutionsof fractional and integer thermo-elastic systems are further discussed via graphs and tables. Thegraphs have shown the closed contact between the exact and LRPSM solutions. For appropriatemodeling, the solutions of fractional problems are plotted and shown to be convergent towardsinteger-order problems solutions. From the tables, it is verified that as the terms of the obtained seriessolution increases, the higher accuracy is achieved quickly. The faster convergence and stability of thesuggested method supports its modification for other fractional higher non-linear complex systemsin nature.
Ion coherence: A physical derivation of high-flux ion transport in biological channel
Authors: Song Bo , Hu Yixiao , Wang Yue , Gao Jun , Jiang Lei 
Published: November 2023

Abstract

Biological ion channels usually conduct the high-flux transport of 107 to 108 ions/s, however the underlying mechanism is still lacking [1-7]. Here, applying the KcsA potassium channel as a typical sample, by multi-timescale molecular dynamics simulations, we demonstrate that there is coherence of K+ ions confined in biological channel, which determines the transport. Specifically, the coherent oscillation state of confined K+ ions with a nanosecond-level lifetime in the channel dominates each of transport events, serving as the physical basis of the high flux of ~108 ions/s. The coherent transfer of confined K+ ions, only taking several picoseconds and having no perturbation on the ion coherence, acts as the directional key of transport. The increase of ion coherence can significantly enhance the ion current by a coherence-induced transition. These findings provide a theoretical evidence supporting that the energy-efficient high-flux ion transport of biological channel is physically derived from ion coherence.
Effect of trabeculectomy in the treatment of primary angle-closure glaucoma combined with cataract: A case control study
Authors: Cao Xianfen , Ou Yulun , Zhou Xiaoping , Peng Zhengwu , Cao Zelie , Zhou Qing 
Published: November 2023

Abstract

Background Elderly cataract patients usually accompany primary angle-closure glaucoma (PACG), leading to a series of pathophysiological changes in the patient’s eyes. While, the treatment of PACG combined with cataracts remains controversial. Methods A retrospective case control study was conducted. One hundred patients with PACG comorbid with cataract who were treated by phacoemulsification, intraocular lens implantation and trabeculectomy were selected as the study group. And another one hundred patients with PACG comorbid with cataract who were treated by phacoemulsification and intraocular lens implantation were selected as the control group. The intraocular pressure (IOP), best corrected visual acuity (BCVA), corneal endothelial cell density, average cell area, anterior chamber depth, anterior chamber angle width, and surgery complications before and after surgery were compared between the two groups. Results One month and three months after surgery, the IOP and BCVA of the study group were lower than those of the control group (P < 0.05). The corneal endothelial cell density of patients in the two groups at one and three months after operation was lower than that before the operation (P < 0.05), and the average cell area was larger than that before the operation (P < 0.05). There was no significant difference in the depth of the anterior chamber and the width of the anterior chamber angle between the two groups (P > 0.05). The depth and width of the anterior chamber angle in the study group were higher than those of the control at one month and three months after surgery (P < 0.05). The complication rate was lower in the study group than in the control group (P < 0.05). Conclusions Phacoemulsification, intraocular lens implantation and trabeculectomy for the treatment of PACG patients with cataract is effective and safe.
PFKFB3 attenuates cisplatin-induced ferroptosis in gastric cancer via dephosphorylation of SLC7A11
Authors: Shi Jiaolong , He Zhanke , Lian Zhiying , Yang Kai , Wu Jiani , Sui Chuyang , Zhang Penghao , Yan Ziyan , Yao Xingxing , Yu Jiang , Li Guoxin , Deng Haijun 
Published: November 2023

Abstract

6-phosphofructo-2-kinase (PFKFB3) is an isoenzyme of the PFKFB family, of which numerous studies have revealed the involvement in tumorigenesis and malignant behaviors in a non-glycolysis-dependent manner. Based on our findings of PFKFB3 in trastuzumab resistance, interestingly, we have found that PFKFB3 significantly attenuated cisplatin cytotoxicity both in vivo and in vitro. We demonstrated that overexpression of PFKFB3 markedly inhibited Erastin- and cisplatin-induced ferroptotic cell death. We further showed that Cystine/glutamate antiporter (xCT) interacts with the phosphatase domain of PFKFB3 and can be dephosphorylated at serine 26 (S26) by PFKFB3. The dephosphorylation of S26 greatly enhances xCT transporter activity, is critical for the production of GSH, and inhibits cisplatin-induced ferroptosis. Notably, erastin reversed PFKFB3-mediated resistance to cisplatinboth in vivo and in vitro. Collectively, our findings open a door to uncover how PFKFB3 promotes cisplatin resistance and may provide a potential target for gastric cancer treatment.