bluuebunny/crossref_metadata_2025_split huggingface dataset:
Sunny, hot and humid nesting locations with diverse vegetation benefit Osmia bees nearby almond orchards in a mediterranean area
Authors: Polidori Carlo , Rodrigo-Gómez Sara , Ronchetti Federico , Ferrari Andrea , Selfa Jesús , Gil-Tapetado Diego 
Published: October 2023

AbstractWild bees (Hymenoptera: Apoidea) play an important role as pollinators of many crops and managed populations of Osmia spp. (Megachilidae), through the installation of trap-nests, proved to be efficient in several fruit orchards. In order to optimize the trap-nest protocols, it is necessary to understand which environmental factors play a major role in the reproductive success of these bees. Here, we studied how climate, land use and vegetation affect nest occupation rate (OR, i.e. total number of colonized tunnels/total number of tunnels in the trap-nest), brood productivity (BP, i.e. total number of brood cells built in a completed nest tunnel) and parasitism rate (PR, i.e. total number of parasitized brood cells/BP) in Osmia bees nearby almond orchards in South-East Spain, a largely understudied Mediterranean area. We found that the summer solar radiation positively influenced all three parameters, while spring solar radiation positively affected OR and BP, and negatively PR. Higher abundance of pastures and forests compared with crops increased OR, though not BP, and reduced PR. Vegetation evenness and diversity of dominant plant species also positively affected OR and BP, while they were unimportant for PR. OR was not affected by climate, but BP increased with maximum temperature in the warmest month and decreased with temperature annual range. PR also increased with high temperature, as well as with precipitation. Arid conditions limited OR and BP and boosted parasitism. Overall, it seems that Osmia bees nearby almond field in this area would benefit from trap-nest installation in well solar-radiated, hot and humid sites with a diverse vegetation. Since we have also found a negative association between PR and BP in nests with at least one parasitized cell, environmental conditions which improve productivity will also likely reduce parasitism in these bees.Implications for insect conservation Optimization of trap-nesting protocols for maintaining abundant Osmia populations is crucial to an effective use of these bees as managed pollinators. In our study we suggest that trap-nests locations should be chosen also taking into account a number of local climatic and habitat factors, given their importance in affecting key traits of reproductive success in these solitary bees.
Evaluation of the effects of silk and polyethylene terephthalate sutures on postoperative complications in impacted lower third molar surgery
Authors: Dilan Orhan Zeynep , Levent Ciğerim , Volkan Kaplan , Mehmet Güzel , Abdurrahman Galayene , Mohammad Alsmadi , Anıl Özyurt 
Published: October 2023

AbstractThe aim of this study was to compare the efficacy of silk and Polyethylene Terephthalate (PET) sutures on postoperative complications in impacted lower third molar surgery. This prospective, randomized, split-mouth, double-blind clinical study was performed between January 2021 and June 2022 at the Faculty of Dentistry, Department of Oral and Maxillofacial Surgery, Van Yüzüncü Yıl University. The patients were categorized into two groups in terms of using suture material. PET suture was used in Group 1, and the silk suture in Group 2 for wound closure following impacted lower third molar surgery. The statistical significance level was accepted as p < 0.05 in the study. Forty patients (21 women, 19 men; mean age: 26.1 ± 7.25 years) were included in the study. When values for swelling and trismus evaluation were analyzed, there was no significant intergroup difference (p > 0.05). However, the VAS values of the silk group patients were higher at the 12th and 24th hours (p < 0.05). In addition, the plaque accumulation value in the silk group was higher than that in the PET group on the second postoperative day (p < 0.05). The results indicated that the plaque accumulation in the PET suture was less on the second postoperative day. Also, PET suture group patients felt less pain during the 12th and 24th hours. These results support to use PET sutures in impacted lower third molar surgery.
Graphical Abstract
Hepatic β-arrestins: potential roles in liver health and disease
Authors: Eissa Alzahraa Muhammad , Hassanin Mohamed H. , Ibrahim Islam A. A. E. H. 
Published: October 2023

AbstractΒ-arrestins are intracellular scaffolding proteins that have multifaceted roles in different types of disorders. In this review article, we gave a summary about the discovery, characterization and classification of these proteins and their intracellular functions. Moreover, this review article focused on the hepatic expression of β-arrestins and their hepatocellular distribution and function in each liver cell type. Also, we showed that β-arrestins are key regulators of distinct types of hepatic disorders. On the other hand, we addressed some important points that have never been studied before regarding the role of β-arrestins in certain types of hepatic disorders which needs more research efforts to cover.
Single-fraction radiosurgery outcomes for large vestibular schwannomas in the upfront or post-surgical setting: a systematic review and International Stereotactic Radiosurgery Society (ISRS) Practice Guidelines
Authors: Tuleasca Constantin , Kotecha Rupesh , Sahgal Arjun , de Salles Antonio , Fariselli Laura , Paddick Ian , Pollock Bruce E. , Régis Jean , Sheehan Jason , Suh John H. , Yomo Shoji , Levivier Marc 
Published: October 2023

Abstract
Purpose
To perform a systematic review of literature specific to single-fraction stereotactic radiosurgery (SRS) for large vestibular schwannomas (VS), maximum diameter ≥ 2.5 cm and/or classified as Koos Grade IV, and to present consensus recommendations on behalf of the International Stereotactic Radiosurgery Society (ISRS).

Methods
The Medline and Embase databases were used to apply the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) approach. We considered eligible prospective and retrospective studies, written in the English language, reporting treatment outcomes for large VS; SRS for large post-operative tumors were analyzed in aggregate and separately.

Results
19 of the 229 studies initially identified met the final inclusion criteria. Overall crude rate of tumor control was 89% (93.7% with no prior surgery vs 87.7% with prior surgery). Rates of salvage microsurgical resection, need for shunt, and additional SRS in all series versus those with no prior surgery were 9.6% vs 3.3%, 4.7% vs 6.4% and 1% vs 0.9%, respectively. Rates of facial palsy and hearing preservation in all series versus those with no prior surgery were 1.3% vs 3.4% and 34.2% vs 40.4%, respectively.

Conclusions
Upfront SRS resulted in high rates of tumor control with acceptable rates of facial palsy and hearing preservation as compared to the results in those series including patients with prior surgery (level C evidence). Therefore, although large VS are considered classic indication for microsurgical resection, upfront SRS can be considered in selected patients and we recommend a prescribed marginal dose from 11 to 13 Gy (level C evidence).
Lessons learned from replicating a study on information-retrieval-based test case prioritization
Authors: Minhas Nasir Mehmood , Irshad Mohsin , Petersen Kai , Börstler Jürgen 
Published: October 2023

AbstractReplication studies help solidify and extend knowledge by evaluating previous studies’ findings. Software engineering literature showed that too few replications are conducted focusing on software artifacts without the involvement of humans. This study aims to replicate an artifact-based study on software testing to address the gap related to replications. In this investigation, we focus on (i) providing a step-by-step guide of the replication, reflecting on challenges when replicating artifact-based testing research and (ii) evaluating the replicated study concerning the validity and robustness of the findings. We replicate a test case prioritization technique proposed by Kwon et al. We replicated the original study using six software programs, four from the original study and two additional software programs. We automated the steps of the original study using a Jupyter notebook to support future replications. Various general factors facilitating replications are identified, such as (1) the importance of documentation; (2) the need for assistance from the original authors; (3) issues in the maintenance of open-source repositories (e.g., concerning needed software dependencies, versioning); and (4) availability of scripts. We also noted observations specific to the study and its context, such as insights from using different mutation tools and strategies for mutant generation. We conclude that the study by Kwon et al. is partially replicable for small software programs and could be automated to facilitate software practitioners, given the availability of required information. However, it is hard to implement the technique for large software programs with the current guidelines. Based on lessons learned, we suggest that the authors of original studies need to publish their data and experimental setup to support the external replications.
Flow Rate Dependency of Steady-State Two-Phase Flows in Pore Networks: Universal, Relative Permeability Scaling Function and System-Characteristic Invariants
Authors: Valavanides Marios S. 
Published: October 2023

AbstractThe phenomenology of steady-state two-phase flow in porous media is conventionally recorded by the relative permeability diagrams in terms of saturation. Yet, theoretical, numerical and laboratory studies of flow in artificial pore network models and natural porous media have revealed a significant dependency on the flow rates—especially when the flow regime is capillary to capillary/viscous and part of the disconnected non-wetting phase remains mobile. These studies suggest that relative permeability models should incorporate the functional dependence on flow intensities. In the present work, a systematic dependence of the pressure gradient and the relative permeabilities on flow rate intensity is revealed. It is based on extensive simulations of steady-state, fully developed, two-phase flows within a typical 3D model pore network, implementing the DeProF mechanistic–stochastic model algorithm. Simulations were performed across flow conditions spanning 5 orders of magnitude, both in the capillary number, Ca, and the flow rate ratio, r, and for different favorable /unfavorable viscosity ratio fluid systems. The systematic, flow rate dependency of the relative permeabilities can be described analytically by a universal scaling function along the entire domain of the independent variables of the process, Ca and r. This universal scaling comprises a kernel function of the capillary number, Ca, that describes the asymmetric effects of capillarity across the entire flow regime—from capillarity-dominated to mixed capillarity/viscosity- to viscosity-dominated flows. It is shown that the kernel function, as well as the locus of the cross-over relative permeability values, are single-variable functions of the capillary number; they are both identified as viscosity ratio invariants of the system. Both invariants can be correlated with the structure of the pore network, through a function of Ca. Consequently, the correlation is associated with the wettability characteristics of the system. Among the potential applications, the proposed, universal, flow rate dependency scaling laws are the improvement of core analysis and dynamic rock-typing protocols, as well as integration into field-scale simulators or associated machine learning interventions for improved specificity/accuracy.
Electrophysiological Activity from the Eye Muscles, Cerebellum and Cerebrum During Reflexive (Classical Pavlovian) Versus Voluntary (Ivanov-Smolensky) Eye-Blink Conditioning
Authors: Todd Neil P. M. , Govender Sendhil , Keller Peter E. , Colebatch James G. 
Published: October 2023

AbstractWe report an experiment to investigate the role of the cerebellum and cerebrum in motor learning of timed movements. Eleven healthy human subjects were recruited to perform two experiments, the first was a classical eye-blink conditioning procedure with an auditory tone as conditional stimulus (CS) and vestibular unconditional stimulus (US) in the form of a double head-tap. In the second experiment, subjects were asked to blink voluntarily in synchrony with the double head-tap US preceded by a CS, a form of Ivanov-Smolensky conditioning in which a command or instruction is associated with the US. Electrophysiological recordings were made of extra-ocular EMG and EOG at infra-ocular sites (IO1/2), EEG from over the frontal eye fields (C3’/C4’) and from over the posterior fossa over the cerebellum for the electrocerebellogram (ECeG). The behavioural outcomes of the experiments showed weak reflexive conditioning for the first experiment despite the double tap but robust, well-synchronised voluntary conditioning for the second. Voluntary conditioned blinks were larger than the reflex ones. For the voluntary conditioning experiment, a contingent negative variation (CNV) was also present in the EEG leads prior to movement, and modulation of the high-frequency EEG occurred during movement. US-related cerebellar activity was prominent in the high-frequency ECeG for both experiments, while conditioned response-related cerebellar activity was additionally present in the voluntary conditioning experiment. These results demonstrate a role for the cerebellum in voluntary (Ivanov-Smolensky) as well as in reflexive (classical Pavlovian) conditioning.
Clinical advances in oncolytic virus therapy for malignant glioma: a systematic review
Authors: Jiang Shan , Chai Huihui , Tang Qisheng , Shi Zhifeng , Zhou Liangfu 
Published: October 2023

Abstract
Purpose
In the past decade, there has been little progress in the treatment of malignant glioma. Recently, oncolytic virus has made great progress in glioma treatment, and a number of clinical trials have shown their potential of prolonging the survival time of glioma patients. Our objective is to evaluate effectiveness and safety of oncolytic virus (OV) in malignant glioma treatment.

Methodology
Based upon PRISMA, we collected relevant published clinical trials by searching medical databases up to January 16, 2023, applying the language restrictions in English and Chinese. We cross-searched the terms: ‘glioma’, ‘glioblastoma’, ‘oncolytic viruses’, ‘oncolytic virotherapy’ with filter ‘clinical trial’. Two researchers independently extracted the data regarding case definitions, published years, trial phase, characteristics of patients, administration of drug, overall survival (OS), and adverse events.

Results
19 published clinical trials in OV treatment of malignant glioma were included in the further systematic review analysis. None of them induced irresistible adverse effects attributing to OV treatment, median overall survival varied from 3.25 to 20.2 months after treatments. According to trials providing patient’s detailed molecular diagnosis, we find that the effectiveness of OV treatment has no significant difference in patients with different IDH or MGMT status.

Conclusions
Current clinical trials have initially shown the potential of oncolytic virotherapy as a new treatment for malignant glioma. Besides development of virus types, the strategy of OV use is an urgent problem to be solved in future clinical application, such as repeated administrations, innovative drug delivery systems, and biomarkers.
Changes in brown adipose tissue induced by resveratrol and its analogue pterostilbene in rats fed with a high-fat high-fructose diet
Authors: Gómez-García Iker , Fernández-Quintela Alfredo , Portillo María Puy , Trepiana Jenifer 
Published: October 2023

AbstractNatural bioactive compounds have attracted a great deal of attention since some of them can act as thermogenesis activators. In recent years, special interest has been placed on resveratrol and its analogue pterostilbene, a dimethylether derivative that shows higher bioavailability. The aim of the present study is to compare the effects of resveratrol and its derivative pterostilbene on the thermogenic capacity of interscapular brown adipose tissue (iBAT) in rats under a high-fat high-fructose diet. Rats were divided into four experimental groups: control, high-fat high-fructose diet (HFHF) and HFHF diet supplemented with 30 mg/kg body weight/day of pterostilbene (PT30) or resveratrol (RSV30), for eight weeks. Weights of adipose tissues, iBAT triglycerides, carnitine palmitoyltransferase 1A (CPT1A) and citrate synthase (CS) activities, protein levels of uncoupling protein 1 (UCP1), sirtuins (SIRT1 and 3), AMP-activated protein kinase (AMPK), glucose transporter (GLUT4), fatty acid synthase (FAS), nuclear respiratory factor (NRF1), hormone-sensitive lipase (HSL), adipose triglyceride lipase (ATGL), CD36 and FATP1 fatty acid transporters, peroxisome proliferator-activated receptor gamma coactivator 1 (PGC1) activation and the batokines EPDR1 and NRG4 were assessed in iBAT. The results show that some key proteins related to thermogenesis were modified by either pterostilbene or resveratrol, although the lack of effects on other crucial proteins of the thermogenic machinery suggest that these compounds were not able to stimulate this process in iBAT. Overall, these data suggest that the effects of stilbenes on brown adipose tissue thermogenic capacity depend on the metabolic status, and more precisely on the presence or absence of obesity, although further studies are needed to confirm this hypothesis.
Scoring AI-generated policy recommendations with Risk-Adjusted Gain in Net Present Happiness
Authors: Breeden Joseph 
Published: October 2023

Abstract
Ethical considerations for assessing the collective benefit of an AI’s policy recommendations are different from assessing the ethical consequences from interacting with an individual. The study of population ethics provides a framework for studying collective benefit or harm in abstract terms. Research into happiness has made significant strides in identifying some key drivers of subjective well-being as measured both individually and collectively across societies. This research examines models from population ethics and statistical studies of subjective well-being to create a measure of benefit with which to judge AI recommendations. These models include refining estimations of the interaction between cultural aspects and economic development and incorporating measures of inequality of happiness and satisfaction through a society. When the impacts of a proposed policy are simulated for multiple successive years, risk discounting is used to measure Net Present Happiness, thus solving the conundrum of considering future generations in ethical considerations as posed in population ethics. Lastly, the Risk-Adjusted Gain in Net Present Happiness is proposed as a reasonable approach to ranking AI policy recommendations and as an AI objective function.
Nutritional diversity and food potential of indigenous pigmented rice landraces from Koraput regions of Eastern Ghats
Authors: Panda Debabrata , Rani Kalpna , Behera Prafulla K. , Pradhan Bhubaneswar , Lenka Sangram K. 
Published: October 2023

AbstractCompressive nutritional, nutraceuticals and mineral profiling was carried out in eight diverse pigmented rice landraces originated from Koraput and compared them with improved variety (IR 64). The proximate compositions such as moisture content varied from 8.23 to 11.65 g 100 g−1, ash 0.68–1.46 g 100 g−1, fat 1.07–2.23 g 100 g−1, protein 7.00–9.63 g 100 g−1, carbohydrate 76.37–80.66 g 100 g−1, fiber 0.11–1.69 g 100 g−1 and energy 346.3–362.11 kcal 100 g−1 in the studied rice lines. These landraces are rich in phenol, flavonoid, and antioxidant concentrations and varied from 3.0 to 9.0 mg g−1, 0.150 to 0.950 mg 100 g−1, and 10.8 to 40.20%, respectively. Principal component analysis explained 47.2% of the overall variation and reflected huge difference between explored genotypes. The heritability and genetic advance varied from 30.22–99.90% and 2.5–111.5%, respectively. In compared to improved IR 64 variety, rich in energy content was recorded in Paradhan, Bhatamali and Haladiganthi indicated its nutritional superiority. Further, exceptional rich in phenol, flavonoid, vitamin C, vitamin E and antioxidant capacity was recorded in Kalachudi, Bedagurumukhi and Kandulakanthi, which may create opportunities for its large-scale commercialization and cultivation. These nutrition rich landraces also hold great potential for future crop improvement programs aimed at enhancing quality.
Capturing Human Environmental DNA: Ethical Challenges
Authors: de Groot Nina F. 
Published: October 2023

AbstractIn May 2023, it was reported that human genomic information can be captured relatively easy and inadvertently from environmental samples, such as air or water. Humans, as well as all other organisms, shed fragments of DNA continuously. There is a large variety of potential applications of such environmental DNA, for instance in biology, but also for criminal justice purposes. However, capturing human DNA from such environmental sources raises ethical issues. This article explores some key ethical issues of human environmental DNA, in particular those revolving around consent, privacy, commodification, and the possibility of genetic surveillance. The article suggests that insights from the digital data protection debate, in particular non-individual-based approaches to data control and governance, can be a valuable starting point for evaluating the ethical, legal, and policy aspects of human environmental DNA. As we leave genetic traces everywhere (just as we also leave digital traces everywhere online), seeking individual control over all of that information seems not only practically hardly possible, but also ethically problematic. Therefore, we need new approaches on how best to articulate and address the challenges that novel genetic information processing techniques bring about. Approaches and concepts from the online digital data debate, such as group privacy and predictive privacy, can offer a valuable way forward to think about how to effectively deal with the complex issues that human environmental DNA raises.
Adapting to online education: insights from computer science teachers
Authors: Mladenović Monika 
Published: October 2023

AbstractThis paper explored the attitudes and roles of computer science (CS) teachers in elementary and high schools in Croatia in the period from completely online to “normal” schooling. The research was conducted in two phases to gain insight into the adaption of online education in schools. The first part of the research was a quantitative study conducted during online education in 2019/2020 among 538 elementary and high school informatics teachers across Croatia. Data were collected from an online survey. The second part of the research was a qualitative study conducted in 2022, employing interviews for data collection. The interview questions were designed based on the survey results mentioned above. The results showed that CS teachers had a significant role in implementing online schools, acting as implementers of tools for online teaching and as helpdesk IT support to other teachers. Still, formal education nowadays is affected by online schooling, and some online practices are now adopted into regular teaching. Therefore, the findings can serve as a guideline for future education related to the digital competencies of teachers and students.