bluuebunny/crossref_metadata_2025_split huggingface dataset:
Single-cell Multiomics Analysis of Myelodysplastic Syndromes and Clinical Response to Hypomethylating Therapy
Authors: Campillo-Marcos Ignacio , Casado-Pelaez Marta , Davalos Veronica , Ferrer Gerardo , Mata Caterina , Mereu Elisabetta , Roué Gael , Valcárcel David , Molero Antonieta , Zamora Lurdes , Xicoy Blanca , Palomo Laura , Acha Pamela , Manzanares Ana , Tobiasson Magnus , Hellström-Lindberg Eva , Solé Francesc , Esteller Manel 
Published: February 2024

Abstract

Alterations in epigenetic marks, such as DNA methylation, represent a hallmark of cancer that has been successfully exploited for therapy in myeloid malignancies. Hypomethylating agents (HMA), such as azacitidine, have become standard-of-care therapy to treat myelodysplastic syndromes (MDS), myeloid neoplasms that can evolve into acute myeloid leukemia. However, our capacity to identify who will respond to HMAs, and the duration of response, remains limited. To shed light on this question, we have leveraged the unprecedented analytic power of single-cell technologies to simultaneously map the genome and immunoproteome of MDS samples throughout clinical evolution. We were able to chart the architecture and evolution of molecular clones in precious paired bone marrow MDS samples at diagnosis and posttreatment to show that a combined imbalance of specific cell lineages with diverse mutational profiles is associated with the clinical response of patients with MDS to hypomethylating therapy.

Significance:
MDS are myeloid clonal hemopathies with a low 5-year survival rate, and approximately half of the cases do not respond to standard HMA therapy. Our innovative single-cell multiomics approach offers valuable biological insights and potential biomarkers associated with the demethylating agent efficacy. It also identifies vulnerabilities that can be targeted using personalized combinations of small drugs and antibodies.
Premonitory symptoms in migraine: A REFORM Study
Authors: Thuraiaiyah Janu , Ashina Håkan , Christensen Rune H , Al-Khazali Haidar M , Wiggers Astrid , Amin Faisal Mohammad , Steiner Timothy J , Ashina Messoud 
Published: February 2024

Background Estimates of proportions of people with migraine who report premonitory symptoms vary greatly among previous studies. Our aims were to establish the proportion of patients reporting premonitory symptoms and its dependency on the enquiry method. Additionally, we investigated the impact of premonitory symptoms on disease burden using Headache Impact Test (HIT-6), Migraine Disability Assessment (MIDAS) and World Health Organization Disability Assessment 2.0 (WHODAS 2.0), whilst investigating how various clinical factors influenced the likelihood of reporting premonitory symptoms. Methods In a cross-sectional study, premonitory symptoms were assessed among 632 patients with migraine. Unprompted enquiry was used first, followed by a list of 17 items (prompted). Additionally, we obtained clinical characteristics through a semi-structured interview. Results Prompted enquiry resulted in a greater proportion reporting premonitory symptoms than unprompted (69.9% vs. 43.0%; p < 0.001) and with higher symptom counts (medians 2, interquartile range = 0–6 vs. 1, interquartile range = 0–1; p < 0.001). The number of symptoms correlated weakly with HIT-6 ( ρ = 0.14; p < 0.001) and WHODAS scores ( ρ = 0.09; p = 0.041). Reporting postdromal symptoms or triggers increased the probability of reporting premonitory symptoms, whereas monthly migraine days decreased it. Conclusions The use of a standardized and optimized method for assessing premonitory symptoms is necessary to estimate their prevalence and to understand whether and how they contribute to disease burden.
From case to context: A case-driven comprehensive review on Kirschner wire migration to the cervical spine and neck
Authors: Hrubovčák Ján , Tulinský Ľubomír , Jelínek Petr , Potičný Slavomír , Roman Jan , Szeliga Jiří 
Published: February 2024

Introduction Osteosynthesis using Kirschner wires constitutes a fundamental technique within the realms of traumatology and orthopaedics. Despite its widespread application and popularity, it is susceptible to migration of the wires. Case Report A 36-year-old patient presented with neck pain; subsequent radiographic imaging identified two Kirschner wires that had migrated to the cervical spine following failed removal after K-wiring of a fractured left clavicle 16 years previously. Surgical removal was undertaken complicated by a parapharyngeal abscess that needed surgical drainage and neurological symptoms in terms of left shoulder weakness and left arm/hand paraesthesia. All neurological symptoms resolved after many months of rehabilitation excepting some residual paraesthesia on the ulnar border of the left hand. Discussion A thorough literature review reveals 30 other cases of K-wire migration to the cervical spine. Vague symptoms are the norm with <25% presenting focal neurological symptoms, with only 6 penetrating the spinal cord, two of which were left with severe deficits. The other 28 patients had no long-term significant deficits. Conclusion The migration of K-wires into the spinal canal, is a rare but recognised complication. Functional outcomes are contingent on spinal cord injuries arising from the implantation. In the absence of spinal cord injury, a high probability of complete functional restoration and symptom resolution exists.
Management of the capsule in trapeziometacarpal joint implant arthroplasty: resection versus repair
Authors: Reischenböck Vanessa , Marks Miriam , Imhof Jenny , Schindele Stephan , Herren Daniel B. 
Published: February 2024

We compared the effects of capsule resection versus capsule suturing in patients treated with a dual-mobility trapeziometacarpal joint prosthesis. We included 131 patients with capsular resection and 57 patients with repair. The mean scores for pain and the brief Michigan Hand Outcomes Questionnaire were similar between the groups preoperatively and at 6 weeks and 1 year postoperatively. Mean key pinch strength was also similar in both groups before surgery and at 1 year, but higher in the capsular resection than in the suture group at 6 weeks. The incidence of complications reported throughout the 1-year postoperative period was not significantly different between the groups. One implant in the capsular resection group was revised for reasons most likely unrelated to capsule management. We conclude that the capsule can be safely resected during trapeziometacarpal joint implant arthroplasty. Level of evidence: III
Null effects of social media ads on voter registration: Three digital field experiments
Authors: Unan Asli , John Peter , Foos Florian , Cheng-Matsuno Vanessa 
Published: February 2024

Civic organisations and progressive campaigns regard digital advertising as an essential method to register to vote low-participation groups, such as ethnic minorities, young voters and frequent home movers like private-sector tenants. Digital strategies appear to be promising in countries like the UK, where the registration process can be completed online, usually in less than 5 minutes, using a web link in the advert. But are typical digital campaigns effective in registering voters? To find out, we provide evidence from three randomised controlled trials: two conducted with advocacy organisations and the third run by the research team, carried out in two types of UK elections (general and local) and assigned either at the aggregate (Study 1 and Study 2) or individual (Study 3) level. Despite wide reach and relatively high rates of engagement, we find that the digital ad campaigns trialed across three studies did not affect under-registered groups’ voter registrations. These null findings raise questions about commonly-used digital advertising strategies to register marginalised groups. They are consistent with other studies that report either null or minimal effects of digital ads on other types of political behaviour.
Correlation of Tibial Tubercle Overgrowth With Increased Posterior Tibial Slope: A Novel Radiographic Assessment
Authors: Rosenthal Reece M. , Hunter Collin D.R. , Froerer Devin L. , Featherall Joseph , Metz Allan K. , Ernat Justin J. , Maak Travis G. , Aoki Stephen K. 
Published: February 2024

Background: An elevated posterior tibial slope (PTS) is associated with an increased risk for anterior cruciate ligament and meniscal injury. Recent evidence suggests that the PTS is elevated in patients with Osgood-Schlatter disease. Purpose: To determine whether there is an association between objective measures of anterior tibial tubercle growth and PTS. Study Design: Cross-sectional study; Level of evidence, 3. Methods: A total of 100 radiographs were randomly selected from a sample of patients who had received a lateral knee radiograph that captured at least 15 cm of the tibia distal to the knee joint line at a single institution between December 2020 and March 2022. The PTS was measured, and tibial tubercle growth was quantified with 2 novel measurements. For these measurements, a line was drawn on the radiograph from the most anterosuperior point on the tibia to the point on the anterior cortex of the tibia 10 cm distal from the starting point. The tibial tubercle height (TTH) was measured as the perpendicular distance from this line to the most prominent portion of the anterior tibia. The anterior tibial tubercle angle (TTA) was measured as the angle between the endpoints of the line made previously and the most prominent portion of the tibial tubercle, with a more acute angle indicating a more prominent tibial tubercle. The relationship between TTA, TTH, and PTS was evaluated using a univariate linear regression model. Results: The mean patient age was 33.1 ± 14.1 years. The mean TTA was 158.6°± 4.7°, the mean TTH was 8.8 ± 2.0 mm, and the mean PTS was 9.7°± 2.6°. A significant correlation was found between PTS and TTA ( r = −0.46; β = −0.46; P < .001) as well as TTH ( r = 0.43; β = 0.43; P < .001). Conclusion: Objective measures of anterior tibial tubercle overgrowth correlated with an elevated PTS. Every 2.2° of anterior TTA deviation from the mean and every 2.3 mm in TTH deviation from the mean correlated with a 1° difference in the PTS. This suggests a link between the development of the tibial tubercle and PTS, and it potentially helps to explain why the PTS is elevated in certain patients.
Cystic fibrosis in Europe: improved lung function and longevity – reasons for cautious optimism, but challenges remain
Authors: Kerem Eitan , Orenti Annalisa , Adamoli Arianna , Hatziagorou Elpis , Naehrlich Lutz , Sermet-Gaudelus Isabelle 
Published: February 2024

BackgroundPrognosis and disease severity in cystic fibrosis (CF) are linked to declining lung function. To characterise lung function by the number of adults in countries with different levels of Gross National Income (GNI), data from the European Cystic Fibrosis Society Patient Registry were utilised.MethodsAnnual data including age, forced expiratory volume in 1 s (FEV1), anthropometry, genotype, respiratory cultures and CF-related diabetes (CFRD) were retrieved between 2011 and 2021. All countries were stratified into GNI per capita to reflect differences within Europe.ResultsA consistent improvement in FEV1% pred and survival was observed among the 47 621 people with CF (pwCF), including subjects with chronicPseudomonas aeruginosainfection, CFRD and/or undernutrition. Mean values of FEV1% pred changed from 85% to 94.2% for children and from 63.6% to 74.7% for adults. FEV1% pred further increased among those carrying the F508del mutation in 2021, when elexacaftor/tezacaftor/ivacaftor was available. The number of adult pwCF increased from 13 312 in 2011 to 21 168 in 2021, showing a 60% increase. PwCF living in European lower income countries did not demonstrate a significant annual increase in FEV1% pred or in the number of adults.ConclusionThis pan-European analysis demonstrates a consistent improvement in FEV1% pred, number of adult pwCF and survival over the last decade only in European higher and middle income countries. Urgent action is needed in the lower income countries where such improvement was not observed. The notable improvement observed in pwCF carrying the F508del mutation emphasises the need to develop treatments for all CF mutations.
Risk factors for failing sub-Tenon’s triamcinolone acetonide for uveitic macular edema
Authors: Reddy Amit K. , Patnaik Jennifer L. , Palestine Alan G. 
Published: February 2024

Abstract
Background
Sub-Tenon’s triamcinolone acetonide (STA) is less effective than intravitreal corticosteroids in the treatment of uveitic macular edema (ME), but does have some relative advantages, including substantially lower cost and decreased risk of post-injection ocular hypertension. It would be useful for clinicians to know which eyes may respond well to STA and not necessarily require intravitreal therapy. The objective of this study is to identify risk factors for failing STA for the treatment of uveitic ME.

Main body
A retrospective cohort study was performed. Medical records were reviewed of patients who underwent STA for the treatment of uveitic ME between January 1, 2013, and July 31, 2022, at the University of Colorado Hospital. Uveitic ME was defined by a central subfield thickness (CST) greater than 320 μm or the presence of intra-retinal cystoid spaces on optical coherence tomography (OCT), or by the presence of petaloid macular leakage on fluorescein angiography (FA). Data collected included age, race/ethnicity, sex, history of diabetes mellitus, anatomic classification of uveitis, use of corticosteroids, use of immunomodulatory therapy, presence of intra-retinal fluid on OCT, CST on OCT, and presence of petaloid macular leakage on FA. STA failure was defined as the need for additional therapy within 12 weeks of STA due to persistent or worsening uveitic ME. One hundred eighty eyes from 131 patients were included. Forty-two eyes (23.3%) were considered treatment failures. In univariate and multivariable analysis, higher baseline CST was associated with a higher likelihood of failing STA (OR 1.17 for each 30 μm increase in CST, P = 0.016).

Conclusions
STA, while not as potent as intravitreal corticosteroids for the treatment of uveitic ME, was still an effective therapy, particularly for patients with lower baseline CST. Given its lower side effect profile and cost compared to intravitreal treatments, clinicians could consider STA as an initial treatment for mild uveitic ME.
Remifentanil improves left ventricular diastolic parameters in patients with impaired diastolic function: a prospective clinical study
Authors: Köner Özge , Şimşek Mustafa Aytek , Kızılcık Nurcan , Koca Çiğdem , Cabbar Ayça Türer 
Published: February 2024

Abstract
Background
Left ventricular diastolic dysfunction has a significant impact on perioperative morbidity and mortality, and its incidence is high in elderly individuals. Anesthetic agents may impair diastolic function, which may increase the incidence of perioperative complications. The aim of this prospective, clinical, phase 4 study was to investigate the effects of remifentanil on left ventricle (LV) diastolic function in patients with diastolic dysfunction. The study was performed on 30 spontaneously breathing subjects (aged 60–80 years) with diastolic dysfunction.

Methods
Thirty patients (aged 60–80 years) with diastolic dysfunction scheduled for surgery were recruited between November 2019 and March 2023. Left ventricle function was evaluated once the intravenous remifentanil infusion reached a target-controlled concentration of 2 ng/ml with transthoracic echocardiography. Analysis of systolic function focused on left ventricular ejection fraction and mean mitral annular S velocity (Sm), whereas diastolic function focused on changes in transmitral peak flow (E), E/A, mitral septal and lateral e’ waves, E/e’ ratios and left atrial volume index following remifentanil infusion.

Results
Diastolic function measures of LV (mitral E/e’, septal and lateral e’ waves) statistically significantly improved (E/e’ from 10.6 ± 2.9 cm.sn− 1 to 9.5 ± 2.2 cm.sn− 1; p = 0.006) following remifentanil infusion. Left atrial volume index decreased following remifentanil infusion without statistical significance (from 55 ± 14.4 ml.cm− 2 to 51.6 ± 13.3 ml.cm− 2; p = 0.1). Systolic function (ejection fraction and Sm) did not change following remifentanil infusion.

Conclusions
Remifentanil improves left ventricular diastolic parameters in patients with preexisting diastolic dysfunction. Our study suggests that remifentanil at a plasma concentration of 2 ng.ml− 1 might be used safely in patients with left ventricular diastolic dysfunction.
Case report: a unique presentation of memantine overdose causing echolalia and hypertension
Authors: Durrani Sana , Ahmed Shaista 
Published: February 2024

Abstract
Background
Since 2003 when memantine was first approved for use in the management of moderate-severe Alzheimer’s dementia, its use has become more widespread and is being explored in other diseases like neuropathic pain, epilepsy, and mood disorders. Our case uniquely highlights two important adverse effects in a patient who overdosed on memantine. One is hypertension, which is easy to overlook as a medication side effect. The other is echolalia which is the repetition of words and phrases spoken by another person. It is commonly seen in children with autism spectrum disorder and has been reported in older adults with head injuries, delirium, and neurocognitive disorders. The aim of this patient story is to highlight the importance of medication reconciliation with caregivers and knowledge of adverse drug reactions in patient management. This case report has been presented previously in the form of an abstract at the American Geriatrics Society Presidential poster session in May 2023.

Case presentation
Our patient is an 86-year-old man with mild dementia and hypertension, who was brought to the emergency department (ED) due to abrupt onset of altered mental status and auditory hallucinations. Investigations including blood work, CT head and an electroencephalogram (EEG) did not reveal an etiology for this change in his condition. Due to elevated blood pressure on presentation, a nicardipine drip was started, and he was given IV midazolam to assist with obtaining imaging. While reviewing medications with his daughter, it was noted that sixty memantine pills were missing from the bottle. Poison control was contacted and they confirmed association of these features with memantine. With supportive care, his symptoms resolved in less than 100 h, consistent with the half-life of memantine. Notably, our patient was started on Memantine one month prior to this presentation.

Conclusions
Hypertensive urgency and echolalia were the most striking symptoms of our patient’s presentation. Though hypertension is a known sign of memantine overdose, it can easily be contributed to medication non-compliance in patients with dementia, being treated for hypertension. According to our literature review, this the first case of memantine overdose presenting with echolalia, a sign that is not commonly associated with adverse reactions to medications. This highlights the importance of an early medication review, especially with caregivers of people with dementia.
Validation and psychometric testing of the Chinese version of the prenatal body image questionnaire
Authors: Wang Qiaosong , Lin Jingjing , Zheng Qirong , Kang Liping , Zhang Xueling , Zhang Kun , Lin Rong , Lin Rongjin 
Published: February 2024

Abstract
Background
The body image during pregnancy potentially affects both short- and long-term maternal and child health outcomes, including pregnancy mood, postpartum weight recovery, and the quality of mother–child interactions. However, research on the impact of body changes during pregnancy in the Chinese population is scarce. A comprehensive, practical, and reliable tool for assessing pregnant women is needed to detect, intervene in, and implement the reduction of physical dissatisfaction risk. This study translated the Prenatal Body Image Questionnaire (PBIQ) into the Chinese version (PBIQ-C) to assess the body image of pregnant women and evaluated its reliability and validity.

Methods
An improved Brislin translation model was used for the translation. A panel of experts determined the content validity. A convenience sample of 429 pregnant women was chosen from three third-class hospitals in different regions of Fujian Province, China. Factor analysis, Pearson’s correlation, retest reliability, and Cronbach’s alpha were employed to evaluate structural validity and reliability.

Results
The final PBIQ-C had five dimensions with 21 items. Exploratory factor analysis obtained a five-factor solution, which accounted for a total of 60.34%. Confirmatory factor analysis showed that the model fit of the five-factor model also reached a satisfactory model fit after modifying: The Comparative Fit Index was 0.93, and the Tucker-Lewis Index was 0.92; the Root Mean Square Error of Approximation was 0.079. The content validity index of the scale ranged from 0.63 ~ 1.00. The Cronbach’s alpha coefficient was 0.95 for the total scale, and the test–retest reliability was 0.80.

Conclusions
The findings indicated that the PBIQ-C is a valid and reliable instrument for assessing women’s body image during pregnancy, which helps in the early identification of body dissatisfaction during pregnancy and enables the early prevention of postpartum depression.
Impact of parental leave system on the childbirth plan among working married women: a three-year follow-up study of the Korean longitudinal survey of women and families
Authors: Jung Yun Hwa , Jang Yun Seo , Park Eun-Cheol 
Published: February 2024

Abstract
Background
The Korean government seeks to balance work and family and alleviate low fertility by implementing a parental leave system. This study aimed to identify the impact of the parental leave system on childbirth among married working women in South Korea.

Methods
This study used three-year follow-up data from the Korean Longitudinal Survey of Women and Families (2016, 2018, and 2020). The number of participants was 324 at baseline. Logistic regressions using a generalized estimating equation model were performed to examine the impact of parental leave on childbirth. Sub-analyses of covariates, childbirth support, and parental leave systems were conducted.

Results
Of workers covered by the parental leave system, 31.7% considered childbirth. Women covered by parental leave were 3.63 times more likely to plan childbirth (95% confidence interval [CI], 1.32–9.99). The tendency to plan childbirth was pronounced among those in their early 30s (adjusted odds ratio [AOR], 7.20) and those who thought that having children was necessary (AOR, 4.30). Child planning was more influenced by leave support (AOR, 6.61) than subsidies.

Conclusions
Parental leave systems can have a positive impact on working married women’s childbirth plans. Although this system was effective in a group interested in childbirth, it did not create a fundamental child plan. Time support is more important than money concerning childbirth plans. The parental leave system had an impact on childbirth plan. Appropriate parenting policies can effectively increase the fertility rate.