bluuebunny/crossref_metadata_2025_split huggingface dataset:
Development and Validation of a Computed Tomography–Based Model for Noninvasive Prediction of the T Stage in Gastric Cancer: Multicenter Retrospective Study (Preprint)
Authors: Tao Jin , Liu Dan , Hu Fu-Bi , Zhang Xiao , Yin Hongkun , Zhang Huiling , Zhang Kai , Huang Zixing , Yang Kun 
Published: February 2024

BACKGROUND

As part of the TNM (tumor-node-metastasis) staging system, T staging based on tumor depth is crucial for developing treatment plans. Previous studies have constructed a deep learning model based on computed tomographic (CT) radiomic signatures to predict the number of lymph node metastases and survival in patients with resected gastric cancer (GC). However, few studies have reported the combination of deep learning and radiomics in predicting T staging in GC.

OBJECTIVE

This study aimed to develop a CT-based model for automatic prediction of the T stage of GC via radiomics and deep learning.

METHODS

A total of 771 GC patients from 3 centers were retrospectively enrolled and divided into training, validation, and testing cohorts. Patients with GC were classified into mild (stage T1 and T2), moderate (stage T3), and severe (stage T4) groups. Three predictive models based on the labeled CT images were constructed using the radiomics features (radiomics model), deep features (deep learning model), and a combination of both (hybrid model).

RESULTS

The overall classification accuracy of the radiomics model was 64.3% in the internal testing data set. The deep learning model and hybrid model showed better performance than the radiomics model, with overall classification accuracies of 75.7% (<i>P</i>=.04) and 81.4% (<i>P</i>=.001), respectively. On the subtasks of binary classification of tumor severity, the areas under the curve of the radiomics, deep learning, and hybrid models were 0.875, 0.866, and 0.886 in the internal testing data set and 0.820, 0.818, and 0.972 in the external testing data set, respectively, for differentiating mild (stage T1~T2) from nonmild (stage T3~T4) patients, and were 0.815, 0.892, and 0.894 in the internal testing data set and 0.685, 0.808, and 0.897 in the external testing data set, respectively, for differentiating nonsevere (stage T1~T3) from severe (stage T4) patients.

CONCLUSIONS

The hybrid model integrating radiomics features and deep features showed favorable performance in diagnosing the pathological stage of GC.
Efficacy and Safety of Nootropic Herbal Medicines in Increasing Cognitive Function in Alzheimer Patients
Authors: Aribowo Luigi Collins , Angelia Ferina , Wijaya Diana , Rumawas Marina Astrid 
Published: February 2024

Background: Alzheimer’s disease is the most common type of dementia found in society and it is estimated that the number of dementia sufferers will increase. Declining cognitive function is a hallmark symptom and the treatment that has been used to combat the symptom is still unsatisfactory and has side effects. This review explores other herbal and nootropic alternative treatments.Methods: Published Randomized Clinical Trials (RCT) and meta-analyses regarding the efficacy and safety of herbal medicine in increasing cognitive function in Alzheimer patients are searched in PubMed and Google Scholar while applying several inclusion and exclusion criteria.Results: 14 articles are retrieved, which are 3 RCTs and 11 meta-analyses, and are analyzed further. Several interventions are examined, which include Ginkgo biloba, Curcuma longa, Crocus sativus, Huperzine A, Panax ginseng, and Chinese herbal medicine. Each of these interventions exert different levels of efficacy and safety, and differ in their price range.Conclusion: Out of all the analyzed interventions, Crocus sativus could be used as a potential treatment for Alzheimer patients due to its comparable level of efficacy and safety to that of standard therapy and cost effective, but there needs to be a standardized extract for the Indonesian population to easily obtain.
Abstrak
Latar belakang: Penyakit Alzheimer merupakan jenis demensia yang paling sering ditemukan dalam masyarakat dan diperkirakan angka penderita akan terus meningkat beberapa tahun kedepannya. Salah satu gejala khas dari penyakit Alzheimer adalah gejala menurunnya fungsi kognitif, dan obatan-obatan yang sekarang dipakai untuk melawan gejala tersebut belum memuaskan dan terdapat beberapa efek samping. Berdasarkan hal tersebut dibuat tinjauan untuk menelusuri terapi alternatif yang bersifat herbaldan nootropik.Metode: Dilakukan penelusuran artikel publikasi Randomized Controlled Trial (RCT) dan meta-analisis mengenai khasiat dan keamanan tanaman obat untuk meningkatkan fungsi kognitif pada pasien Alzheimer dalam database PubMed dan Google Scholar dengan menerapkan beberapa kriteria inklusi dan kriteria eksklusi.Hasil: Terdapat 14 artikel berupa 3 RCT dan 11 meta-analisis yang dianalisa lebih lanjut. Beberapa intervensi yang ditelusuri adalah Ginkgo biloba, Curcuma longa, Crocus sativus, Huperzine A, Panax ginseng, dan Obat herbal Cina. Masing-masing intervensi memiliki khasiat untuk meningkatkan fungsi kognitif, tingkat keamanan, dan rentang harga yang berbeda.Kesimpulan: Dari semua intervensi yang dianalisa, Crocus sativus dapat menjadi terapi alternatif untuk pasien Alzheimer dikarenakan intervensi ini dapat meningkatkan fungsi kognitif, memiliki tingkat keamanan yang setara dengan terapi standar dengan harga terjangkau, namun perlu adanya sediaan ekstrak terstandard yang dapat dijangkau masyarakat Indonesia.
PENGGUNAAN MULTI NUTRIENT SAUCE (MNS) DAN INDIGOFERA DALAM RANSUM KOMERSIAL DAN PENGARUHNYA TERHADAP PERTAMBAHAN BOBOT TUBUH, KONSUMSI RANSUM, DAN KONVERSI RANSUM
Authors: Hati Diah Permata , Erwanto Erwanto , Liman Liman , Adhianto Kusuma , Tantalo Syahrio , Noer Irmayani , Hasiib Etha' Aziza 
Published: February 2024

Penelitian ini bertujuan untuk mengetahui pengaruh penggunaan multi nutrient sauce dan indigofera sp. pada ransum terhadap pertambahan bobot tubuh, konsumsi ransum, dan konversi ransum pada sapi potong. Penelitian ini dilaksanakan pada September 2022--November 2022 di Desa Negeri Katon, Kecamatan Negeri Katon, Kabupaten Pesawaran, Provinsi Lampung. Penelitian ini dilakukan menggunakan Rancangan Acak Kelompok (RAK) dengan 3 perlakuan dan 4 kelompok, dengan menggunakan 12 sapi potong. Perlakuannya adalah R1 ; Ransum Basal (Konsentrat Grumi Feed A) 60% + Hijauan (Silase tebon jagung) 40%, R2 ; R1 + multi nutrient sauce 6,45 % R3 ; R2 + Indigofera sp. 10%. Hasil penelitian pada konsumsi ransum sapi potong sebesar (R1 10,80 ± 0,90 ; R2 11,23 ± 1,78 ; dan R3 11,65 ± 1,35) kg/hari, hasil pada pertambahan bobot badan sapi potong sebesar (R1 1,29 ± 0,32 ; R2 0,71 ± 0,28 ; dan R31,40 ± 0,19) kg/hari, hasil pada konversi ransum sapi potong sebesar (R1 9,75 ± 4,79 ; R2 16,79 ± 3,34 ; dan R3 8,44 ± 1,63 0,47). Hasil penelitian menunjukkan bahwa interaksi perlakuan tidak berpengaruh nyata (P>0,05) terhadap konsumsi ransum, pertambahan bobot tubuh, dan konversi ransum.
TOTAL ASAM, KEASAMAN, DAN VISKOSITAS YOGHURT SUSU SAPI DENGAN MENGGUNAKAN KOMBINASI STARTER YANG BERBEDA
Authors: Arzakiyah Fina , Wanniatie Veronica , Husni Ali , Qisthon Arif 
Published: February 2024

Penelitian ini bertujuan untuk mengetahui pengaruh kombinasi starter bakteri terhadap kualitas fisik yoghurt susu sapi yang meliputi total asam, keasaman dan viskositas. Penelitian ini dilaksanakan pada Januari 2023 di Laboratorium Produksi Ternak, Jurusan Peternakan Fakultas Pertanian Universitas Lampung dan pengujian sampel dilakukan di Laboratorium Teknologi Hasil Pertanian Politeknik Negeri Lampung. Penelitian ini dilakukan menggunakan Rancangan Acak Lengkap (RAL) dengan 4 perlakuan yaitu P1 (Streptococcus thermophilus + Lactobacillus bulgaricus); P2 (Streptococcus thermophilus + Lactobacillus acidophilus + Bifidobacterium); P3 (Streptococcus thermophilus + Lactobacillus acidophilus + Bifidobacterium+ Lactobacillus bulgaricus); dan P4 (Streptococcus thermophilus + Lactobacillus acidophilus + Bifidobacterium + Lactobacillus casei) dan diulang sebanyak 4 kali. Peubah yang diamati meliputi total asam, keasaman dan viskositas. Data yang diperoleh dianalisis menggunakan analisis ragam pada taraf nyata 5%. Hasil penelitian menunjukkan bahwa kombinasi starter bakteri berpengaruh nyata (P<0,05) terhadap viskositas dengan nilai tertinggi 2.918,00 cP dan total asam dengan nilai tertinggi 0,94% pada kombinasi starter bakteri Streptococcus thermophilus, Lactobacillus acidophilus, Bifidobacterium, dan Lactobacillus casei. Namun tidak berpengaruh nyata terhadap nilai pH.
Dispositivo de segurança para uso odontológico: uma abordagem interprofissional entre Design, Engenharia e Saúde – iDES
Authors: Natália Mattos da Silva  , Costa Diogo Pontes , Ruzza Nicolle Doneda , Merino Eugenio Andrés Díaz , Merino Giselle Schmidt Alves Diaz 
Published: February 2024

As clínicas odontológicas vinculadas ao curso de graduação e pós-graduação de odontologia são os locais em que os estudantes iniciam a prática da profissão por meio do atendimento à comunidade. Neste cenário, um dos procedimentos mais comuns praticados é o de aplicação de anestesia local dentária, fundamental para a realização de cirurgias e restaurações, e uma das causas de acidentes com perfuração. Mediante esse contexto, esta pesquisa teve como objetivo Desenvolver um dispositivo de segurança odontológica para uso da seringa Carpule de anestesia dentária por uma equipe interprofissional (Design, Engenharia e Saúde). Para o desenvolvimento do projeto do Dispositivo de segurança foi utilizado o Guia de Orientação para o Desenvolvimento de Projetos (GODP). Esta pesquisa foi dividida em duas fases: Fase 1 - pesquisas bibliográficas sobre ergonomia, segurança do trabalho e acidentes envolvendo perfurocortantes e estudantes de odontologia; e Fase 2 - Desenvolvimento do Dispositivo de segurança por meio de impressão tridimensional com base no levantamento de dados, questionários, entrevistas e testes. Foram validadas 41 respostas do questionário, sendo que 34% (n=14) dos estudantes relataram ter se acidentado com a seringa, 86% (n=12) do sexo feminino, 14% (n=2) do sexo masculino e 50% (n=7) dos acidentados estavam na 8ª, 9ª e 10ª fases do curso. A respeito do momento em que os acidentes ocorreram, 43% (n=6) relataram que o acidente ocorreu no reencape e 43% (n=6) durante o procedimento. 90% (n=37) relataram a importância e necessidade de dispositivos de segurança para o manuseio da seringa. Com as entrevistas foi possível complementar as informações levantadas, mapear o processo de administração da anestesia e identificar os momentos críticos. Assim, foi desenvolvido o projeto do dispositivo de segurança odontológica, o qual possibilita o reencape e descarte seguro da agulha utilizada na anestesia local dentária. Após testes em laboratório e contexto real, verificou-se a viabilidade técnica e seu potencial na proteção dos profissionais de saúde. Com relação à proteção legal do Dispositivo, foi solicitado junto ao INPI e, após a análise dos setores competentes, foi verificado o potencial dos requisitos de patenteabilidade (novidade, atividade inventiva e aplicação industrial) previstos na Lei de Propriedade Industrial.
Subcutaneous hydromorphone hydrochloride provides antinociception with transient adverse effects in four-toed hedgehogs (Atelerix albiventris)
Authors: Peterson Macy L. , Mans Christoph , Doss Grayson A. 
Published: February 2024

Abstract

OBJECTIVE
To evaluate the efficacy and safety of hydromorphone administered SC in four-toed hedgehogs (Atelerix albiventris).

ANIMALS
12 healthy adult hedgehogs.

METHODS
Hedgehogs underwent 2 randomized, blinded, placebo-controlled, complete crossover studies. Hind limb withdrawal latencies in response to an acute thermal noxious stimulus were measured to evaluate the antinociceptive efficacy of hydromorphone. Baseline latencies were obtained prior to injection and collected again at 0.5, 1, 2, 4, and 6 hours following injection. Based on pilot studies, single doses of SC hydromorphone at 0.15 and 0.3 mg/kg were evaluated for efficacy in crossover trials. Safety of single (0.15 and 0.3 mg/kg) and multiple doses of hydromorphone (0.3 mg/kg, SC, q 4 h, for 3 doses) was also assessed. In addition to monitoring behavior during latency measurements, animals were evaluated for overt sedation and daily changes in food intake, body weight, and running wheel activity for 6 days after injection to evaluate for adverse effects.

RESULTS
Hydromorphone at 0.15 mg/kg provided antinociception lasting < 4 hours, and 0.3 mg/kg provided antinociception lasting < 6 hours. Hydromorphone produced transient abnormal behaviors at both doses, including vocalization, chewing motions of the jaw, and paw raising. There were no statistically significant differences in body weight or running wheel activity between treatments for single or multiple doses of hydromorphone. Three doses of 0.3 mg/kg hydromorphone (q 4 h) produced a statistically significant decrease (median, –9.7%; range, –64% to 10%) in 6-day total food intake.

CLINICAL RELEVANCE
Subcutaneous hydromorphone (0.15 to 0.3 mg/kg) can be used for short-term antinociception with transient adverse effects in hedgehogs.
KAJIAN KEPUASAN WISATAWAN TERHADAP LOYALITAS DESTINASI WISATA PANTAI KUTA BALI DI INDONESIA
Authors: Alvin  , Tunjungsari Hetty Karunia 
Published: February 2024

Pantai Kuta merupakan salah satu destinasi wisata yang sampai saat ini banyak dikenal oleh wisatawan baik domestik maupun mancanegara. Tujuan penelitian ini adalah untuk menguji apakah Perceived Service Quality, Perceived Value merupakan prediktor positif terhadap Destination Loyalty dan Tourist Satisfaction. Penelitian ini melibatkan 200 sampel dari kalangan mahasiswa yang pernah berkunjung ke Pantai Kuta, Bali, untuk tujuan berwisata lebih dari 1 kali. Teknik pengambilan sampel yang dipilih adalah dengan menggunakan convenience sampling. Data yang diperoleh kemudian diolah dengan menggunakan PLS-SEM versi 3. Hasil penelitian ini menunjukkan bahwa Perceived Value memiliki pengaruh yang positif terhadap Tourist Satisfaction dan Destination Loyalty, adapun Perceived Service Quality tidak memiliki pengauh yang signifikan pada kedua variabel dependen. Implikasi hasil penelitian ini dapat menjadi masukan bagi organisasi manajemen destinasi (DMO), khususnya wisata pantai, dalam membuat strategi untuk meningkatkan kepuasan dan loyalitas wisatawan. Secara teoretis, implikasi hasil penelitian ini memberikan pengembangan pada kajian mengenai kepuasan dan loyalitas wisatawan.

Kuta Beach is a tourist destination that is widely known by both domestic and foreign tourists. The purpose of this study is to examine whether Perceived Service Quality and Perceived Value are positive predictors of Destination Loyalty as well as Tourist Satisfaction. This study involved 200 samples from students who had visited Kuta Beach, Bali, more than 1 time for the purpose of vacation. The sampling technique chosen is to use convenience sampling. The data obtained was then processed using PLS-SEM version 3. The results of this study show that Perceived Value has a positive influence on Tourist Satisfaction and Destination Loyalty, while Perceived Service Quality does not have a significant influence on both variables. The implications of this study can be suggestions for destination management organization (DMO), especially beach tourism, in making strategies to increase tourist satisfaction and loyalty. Theoretically, the implications of the results of this study provide development in the study of tourist satisfaction and loyalty.
FAKTOR PENENTU KINERJA INOVASI PEMIMPIN MAL DI JAKARTA: PERAN ORIENTASI KEWIRAUSAHAAN DAN KEPEMIMPINAN KEWIRAUSAHAAN
Authors: Bramaputri Sia Lily , Marizar Eddy Supriyatna 
Published: February 2024

Kinerja inovasi para pimpinan mal sangat penting bagi kelangsungan mal di Jakarta. Oleh karena itu, perlu ditingkatkan. Kinerja inovasi pemimpin mal di Jakarta dapat ditingkatkan salah satunya dengan cara meningkatkan orientasi kewirausahaan dan kepemimpinan kewirausahaan. Tujuan penelitian ini adalah agar dapat melakukan analisis faktor yang menentukan kinerja inovasi pimpinan mal di Jakarta. Metode penelitian yang digunakan adalah metode penelitian kuantitatif dan dilakukan di Jakarta dengan subjek penelitian adalah pimpinan mall yang berada di bawah kelompok XYZ. Data penelitian didasarkan pada sumber data primer yaitu melalui survei dengan menggunakan kuesioner berdasarkan tiga variabel yang ingin diukur yaitu orientasi kewirausahaan, kepemimpinan kewirausahaan, dan kinerja inovasi. Dari populasi tersebut diambil sampel penelitian sebanyak 129 orang berdasarkan metode simple random sampling. Penelitian ini memberikan hasil bahwa orientasi kewirausahaan serta kepemimpinan kewirausahaan memberikan pengaruh positif dan signifikan terhadap kinerja inovasi pimpinan mal di bawah kelompok XYZ. Kontribusi penelitian ini adalah penelitian ini dapat menjadi rujukan dalam mengembangkan berbagai program dasar kepemimpinan bagi para pemimpin mal dengan memperhatikan kapasitas orientasi kewirausahaan dan kepemimpinan kewirausahaan.

The innovation performance of mall leaders is very important for the survival of malls in Jakarta. Therefore, it needs to be improved. Several factors that can improve the innovation performance of mall leaders in Jakarta are entrepreneurial orientation and entrepreneurial leadership. The aim of this research is to be able to analyze the factors that determine the innovation performance of mall leaders in Jakarta. The research method used was a quantitative research method and was carried out in Jakarta with the research subjects being mall leaders under the XYZ group. Research data is based on primary data sources, namely through surveys using questionnaires based on the three variables to be measured, namely entrepreneurial orientation, entrepreneurial leadership, and innovation performance. From this population, a research sample of 129 people was taken based on the simple random sampling method. This research shows that entrepreneurial orientation and entrepreneurial leadership have a positive and significant influence on the innovation performance of mall leaders under the XYZ group.
HUBUNGAN TARIF ELECTRONIC ROAD PRICING DENGAN KINERJA JALAN
Authors: Pangestu Kenneth Putra , Najid  
Published: February 2024

Electronic Road Pricing (ERP) adalah cara untuk meningkatkan biaya penggunaan kendaraan pribadi dimanapengguna kendaraan pribadi dikenakan biaya untuk melintasi jalan dan diharapkan beralih menggunakantransportasi umum. Sistem ERP biasanya menggunakan kombinasi sensor dan kamera untuk mendeteksi lalu lintaskendaraan di jalan seperti In-Vehicle Unit untuk mengumpulkan biaya secara otomatis. Responden dalam penelitianini beraktivitas dari pukul 06.00 - 18.00 WIB dan berjumlah kurang lebih sebanyak 100 orang. Pengumpulan dataakan dilakukan dengan menggunakan kuesioner melalui Google Form. Mengetahui bagaimana sistem tarif ElectronicRoad Pricing (ERP) di kota DKI Jakarta. Penelitian ini akan membahas peraturan dan kebijakan apa saja mengenaitarif yang akan diterapkan pada Electronic Road Pricing (ERP) di kota DKI Jakarta, mengetahui hubungan antarapelayanan dan tarif.Kata kunci: Electronic Road Pricing, ERP, tarif, sistem tarif
Electronic Road Pricing (ERP) is a way to increase the cost of private vehicle use where private vehicle users arecharged for crossing roads and are expected to switch to using public transportation. ERP systems typically use acombination of sensors and cameras to detect vehicle traffic on the road such as In-Vehicle Units to collect the feesautomatically. Respondents in this study are on the move from 06.00 - 18.00 WIB and total approximately 100 people.Data collection will be conducted using a questionnaire through Google Form. Knowing how the Electronic RoadPricing (ERP) tariff system in DKI Jakarta city. This research will discuss what regulations and policies regardingtariffs that will be applied to Electronic Road Pricing (ERP) in the city of DKI Jakarta, knowing the relationshipbetween services and tariffs.Keywords: Electronic Road Pricing, ERP, tariff, tariff system
ANALISIS DISTRIBUSI TEGANGAN ARAH HORIZONTAL DENGAN SAMBUNGAN BAUT PADA PELAT TARIK MENGGUNAKAN SOFTWARE AUTODESK INVENTOR
Authors: Halim Kritananda Tantra , Leman Sunarjo 
Published: February 2024

Steel a crucial element that is often used in construction because of its efficient workmanship and high tensile strength. Several types of connections will affect the modeling and analysis of the structure in the early stages of planning. The distribution in steel bolted joints will vary depending on plate dimensions and bolt arrangement. The stress that occurs in the steel plate will affect the distribution of stress on each bolt. This study analyzes the distribution of forces in tension bolt connections using the FEM Autodesk Inventor. This research conducted using steel plate (fy = 780 Mpa and E = 205000 MPa) and bolt ISO 4010, nut ISO 4032, washer ISO 7090. The results showed that compressive stress distribution in horizontal direction on plates and bolts is in the form of a parabolic curve with the outermost edge having a value compressive stress which is greater than the inner edge compressive stress with a difference of about 30% -45%. On the outer edges of the plate there is a considerable tensile stress of 300% -500%. This study produced an equation for the distribution of horizontal compressive stresses for each bolt configuration. Increasing number of bolts, the compressive stress in the horizontal direction will be more evenly distributed.
Abstrak
Baja merupakan elemen krusial yang sering digunakan dalam konstruksi karena pengerjaannya yang efisien dan memiliki kuat tarik yang cukup tinggi. Beberapa tipe sambungan akan mempengaruhi permodelan dan analisis struktur pada tahap awal perencanaan. Distribusi pada sambungan baut baja tentu akan bervariasi bergantung pada dimensi pelat dan susunan baut. Besaran tegangan yang terjadi pada pelat baja akan mempengaruhi juga distribusi tegangan pada setiap bautnya. Penelitian ini menganalisis distribusi gaya pada sambungan baut tarik menggunakan metode elemen hingga dengan menggunakan Autodesk Inventor (2023). Penelitian ini dilakukan menggunakan pelat baja dengan fy = 780 Mpa dan E = 205000 MPa dan jenis baut ISO 4010, mur ISO 4032, washer ISO 7090. Hasil penelitian menunjukan bentuk distribusi tegangan tekan arah horizontal pada pelat dan baut berbentuk kurva parabolik dengan tepi terluar yang memiliki nilai tegangan tekan yang lebih besar dari tegangan tekan tepi dalam dengan perbedaan sekitar 30%-45. Pada bagian tepi terluar kiri maupun kanan pelat terjadi tegangan tarik yang cukup besar sebesar 300%-500%. Penelitian ini juga menghasilkan persamaan distribusi tegangan tekan arah horizontal pada setiap konfigurasi baut dan pelat. Dengan bertambahnya jumlah susunan baut maka tegangan tekan arah horizontal akan terdistribusi lebih merata.