bluuebunny/crossref_metadata_2025_split huggingface dataset:
Identification of potential risks in ensuring the sustainable quality of dietary breads
Authors: Reznichenko I. Yu. , Egushova E. A. 
Published: November 2023

Relevance. The implementation of the HACCP principles is considered as a universal component of preventing possible hazards or reducing the risk to an acceptable level. Structuring the safety management system for small enterprises producing bakery products and using non-waste technologies presents certain difficulties, in connection with which the proposed model can find practical significance.Methods. The object of the study was dietary loaves based on a mixture of wheat flour, wholemeal rye, peeled rye, bread crumbs and Jerusalem artichoke powder. When performing the work, quality tools were used: the method of expert scoring to assess the likelihood and severity of identified hazards in the production of dietary bread; decision tree method for determining critical control points that affect the safety of diet crisps.Results. To manage risks in the production of dietary breads, critical control points are identified, a description of the CCP is given, and the distinctive features of the HACCP plan are presented. The proposed organization of quality and safety control can be applied in technologies for the production of bread with the inclusion of bread crumbs or other ingredients similar in properties to crumbs in the recipe.
ANALISIS PENINGKATAN MINAT BACA SISWA SD DI KOTA LANGSA MELALUI CERITA RAKYAT DALAM BENTUK KOMIK
Authors: Dayanti Selvi 
Published: November 2023

Abstrak

Hasil dari pengamatan pada pembelajara bahasa indonesia dalam membaca cerita untuk memahami isi cerita yang dilaksanakan terhadap siswa SD kelas V kurang maksimal. Kurang mahirnya siswa pada penyimpulan cerita disebabkan karena gurunya tidak memakai media pada pembelajarannya, sehingga proses pembelajaran menjadi kurang menarik. Oleh sebab itu peneliti melaksanakan pengamatan tindakan guna memperbaiki pembelajaran menyimpulkan cerita dalam media komik. Tahapan penelitian menggunakan tiga tahapan, yaitu observasi, tes hasil pembelajaran, dan catatan lapangan. Hasil pengamatan menunjukan bahwa pada setiap pertemuan siklus aktivitas guru mendapatkan persentase 100% dengan jumlah nilai siklus-I pada pertemuan pertama dan kedua sebesar 76,2 dan 81,3. Sedangkan siklus-II dengan jumlah nilai pada pertemuan pertama dan kedua sebesar 84,1 dan 91,3. Untuk hasil pembelajaran menyimpulkan isi dalam cerita meningkat pada siklus I dan II sebesar 72,3 dan 81,1dengan total ketuntasan keduanya adalah 67,6% dan 82,87%. Kendala yang di dapati selama proses pembelajaran adalah kurangnya warna pada komik, sehingga hanya monoton berwarna hitam. Tetapi itu bisa di atasi dengan membuat corak warna baru pada komiknya. Oleh karena itu, komik sangat cocok untuk digunakan dalam media pembelajaran membaca, karena terlihat dapat meningkatkan nilai pembelajaran.
Kata kunci:Komik, media, membaca

Abstract

The results of observations on Indonesian language learners in reading stories to understand the contents of the stories carried out on fifth grade elementary school students were less than optimal. The students' lack of proficiency in inferring stories was caused by the teacher not using media in their learning, so the learning process became less interesting. Therefore, researchers carry out action observations to improve learning to conclude stories in comic media. The research phase used three stages, namely observation, learning outcomes tests, and field notes. The results of the observations showed that at each meeting of the activity cycle the teacher got a percentage of 100% with the sum of the cycle-I scores at the first and second meetings of 76.2 and 81.3. While cycle-II with the total value at the first and second meeting of 84.1 and 91.3. For learning outcomes, concluding the content in the story increased in cycles I and II by 72.3 and 81.1 with the total completeness of both being 67.6% and 82.87%. The obstacle encountered during the learning process was the lack of color in comics, so only the monotone was black. But that can be overcome by making a new color pattern on the comic. Therefore, comics are very suitable for use in reading learning media, because they seem to increase the value of learning.
Keywords:Comic, Media, Reading.
Perfil epidemiológico e experiências dos médicos do estado do Acre na pandemia de COVID-19
Authors: Farias Crysdian Janke , Figueiredo Thaylon Fernando Bonatti , Nobre Felipe de Souza , Maia Simone Aparecida Leal Buso , Niemeyer Gustavo Lima , Rodrigues Caio Vinicius Magalhães , Ribeiro Rebecca Heidrich Thoen 
Published: November 2023

Introdução: a pandemia do novo coronavírus tornou-se um dos principais motivos de preocupação global. O Sars-CoV-2 é um vírus transmitido por gotículas em suspensão no ar e infecta principalmente as vias respiratórias, causando também sintomas sistêmicos. Neste cenário, a população médica é particularmente importante, dado que está mais exposta aos pacientes contaminados e, portanto, possui maior risco de contaminação. Objetivos: apresentar o perfil epidemiológico dos médicos no estado do Acre e analisar variáveis que podem influenciar o risco de infecção dos médicos acrianos por Sars-CoV-2, bem como analisar e comparar as estatísticas de infecção entre médicos e a população em geral. Metodologia: trata-se de um estudo transversal, realizado por meio de questionário auto-preenchido enviado por redes sociais e e-mail para a população de médicos acrianos que trabalham no setor público do estado do Acre. As variáveis foram analisadas em frequências das respostas para idade, sexo, infecção, treinamento e uso de EPI, além relacionadas conforme interesse para o estudo. Resultados e discussão: Os resultados mostraram que há relação entre o trabalho na linha de frente por médicos no estado do Acre e maior risco de infecção por COVID-19. Mas não houve associação significativa entre infectividade e idade, sexo, tipo de atendimento prestado, nível de atendimento prestado, uso de tipos específicos de EPI ou quantidade de horas trabalhadas. Conclusão: os achados desse estudo mostram a importância do treinamento e da consideração de múltiplas variáveis no trabalho direto com pacientes de contaminados por COVID-19.
Mobilização precoce em pacientes com COVID-19
Authors: Machado Vithoria Gabrielle Viana da Silva , Albuquerque Ianara Barros 
Published: November 2023

O trabalho por ora apresentado objetivou avaliar, através de uma revisão bibliográfica, o papel do fisioterapeuta na mobilização precoce em pacientes com COVID-19. Para isso, foi realizada uma revisão sistemática realizada Artigos, livros, dissertações, diretrizes e teses disponíveis nas seguintes bases de dados online: Scientific Eletronic Library Online (SciELO), Publisher Medline (PubMed), Literatura Latino- Americana e do Caribe em Ciências da Saúde (Lilacs), Physiotherapi Evidenci Database (PEDro) no formato de artigos científicos, teses e dissertações, provenientes ao tema dentro dos critérios de inclusão e exclusão, publicados no período entre 2020 a 2021, nos idiomas português, inglês e espanhol. A estratégia de busca foi baseada no método PICO utilizando descritores e operadores booleanos: “Fisioterapia”, “Mobilização precoce”, “Ventilação mecânica”, “Pacientes críticos”, “UTI” e “Reabilitação”. Durante as buscas, foram encontradas 123 citações que, após a exclusão de duplicatas, totalizou-se 61 citações. Foi procedida a análise e título e resumo, 40 citações foram excluídas e 21 estudos foram selecionados para leitura na íntegra. 10 estudos foram excluídos por não atenderem aos critérios de inclusão, e 11 estudos foram incluídos na revisão. Concluiu-se com o desenvolver do trabalho que os fisioterapeutas tiveram e ainda têm o papel de fornecer intervenções para mobilização, exercício e reabilitação, especialmente para pacientes em risco de desenvolver declínio funcional.
A RESPON KEMOTERAPI FLUDARABINE PADA HAIRY CELL LEUKEMIA
Authors: Tandya Renny 
Published: November 2023

HCL is part of a rare B-cell lymphoproliferative disorder and is a subtype of Chronic Lymphocytic Leukemia. It is characterized by progressive pancytopenia, splenomegaly, and bone marrow hypercellularity. Patients often come because of abnormal complete blood count results or complications such as infection. This case report explains a case of a 41-year-old woman who had recurrent shortness of breath and cough as symptoms, where the patient had a history of acute myeloblastic leukemia (AML) with non-routine fludarabine chemotherapy. After receiving treatment and underwent further investigations in the form of peripheral blood smear and bone marrow aspiration examination, it was found that the patient had hairy cell leukemia. Fludarabine was given to the patient and it is reported to give effect partial remission (based on last bone marrow aspiration) along with pancytopenia as a clinical manifestation from myelosuppression as a side effect for long-term used fludarabine.
HCL is part of a rare B-cell lymphoproliferative disorder and is a subtype of Chronic Lymphocytic Leukemia. It is characterized by progressive pancytopenia, splenomegaly, and bone marrow hypercellularity. Patients often come because of abnormal complete blood count results or complications such as infection. This case report explains a case of a 41-year-old woman who had recurrent shortness of breath and cough as symptoms, where the patient had a history of acute myeloblastic leukemia (AML) with non-routine fludarabine chemotherapy. After receiving treatment and underwent further investigations in the form of peripheral blood smear and bone marrow aspiration examination, it was found that the patient had hairy cell leukemia. Fludarabine was given to the patient and it is reported to give effect partial remission (based on last bone marrow aspiration) along with pancytopenia as a clinical manifestation from myelosuppression as a side effect for long-term used fludarabine.
Diagnostic accuracy and microbial profiles of tuberculous pleurisy: a comparative study of metagenomic next generation sequencing and GeneXpert Mycobacterium tuberculosis
Authors: Huang Fengxiang , Wang Haoran , Qiao Ruiping , Peng Qiang , Zhao Chang , Miao Lijun 
Published: November 2023

IntroductionThere is a clinical challenge in diagnosing tuberculous pleurisy accurately and promptly, highlighting the urgent need for a rapid and sensitive diagnostic method. This study aimed to evaluate the diagnostic accuracy of metagenomic next-generation sequencing (mNGS) and GeneXpert Mycobacterium tuberculosis (MTB) for identifying tuberculous pleurisy and analyzing the microbial profiles of both tuberculous and non-tuberculous pleural effusions.MethodsThe study enrolled 31 patients with suspected tuberculous pleurisy, of which 15 were confirmed to have tuberculous pleurisy and subsequently allocated to the tuberculous pleurisy group (TP group), while the remaining 16 individuals were assigned to the non-tuberculous pleurisy group (NTP group). mNGS and GeneXpert MTB were performed on pleural effusion samples, and the diagnostic accuracy of both tests was compared. We employed established formulas to compute crucial indicators, including sensitivity, specificity, missed diagnosis rate, misdiagnosed rate, positive predictive value (PPV), and negative predictive value (NPV).ResultsThe results showed that both tests had high specificity (100%) and positive predictive value (100%) for detecting tuberculous pleurisy, along with comparable sensitivity (46.67% for mNGS and 40.0% for GeneXpert MTB). Further analysis of the combined efficacy of mNGS and GeneXpert MTB showed that the combined test had a sensitivity of 66.67% and a specificity of 100%. mNGS analysis revealed that MTB was detected in 7 out of 15 patients with tuberculous pleural effusions, while non-tuberculous pleural effusions were associated with a diverse range of microbial genera and species. The most frequently detected genera at the microbial genus level in the NTP group were Microbacterium spp. (6/16), Prevotella spp. (5/16), and Campylobacter spp. (5/16).DiscussionThese findings suggest that mNGS and GeneXpert MTB are useful diagnostic tools for identifying patients with tuberculous pleurisy, and mNGS can provide valuable insights into the microbial profiles of both tuberculous and non-tuberculous pleural effusions.
The effect of instrumental and vocal musical experience on tone categorical perception in individuals in a Chinese dialect area
Authors: Hao Jiayi , Zhong Yuhuan , Li Hong , Li Jianbo , Zheng Maoping 
Published: November 2023

IntroductionPrevious studies have shown that music training modulates adults’ categorical perception of Mandarin tones. However, the effect of music training on tone categorical perception ability in individuals in Chinese dialect areas remains unclear.MethodsWe recruited three groups of college students majoring in music in Chongqing, a dialect area in southwestern China. These groups included an instrumental music group (n = 31), a vocal music group (n = 32), and an instrumental-vocalist music group (n = 30). Additionally, we recruited a group of college students who did not receive any music training (n = 32). The accuracy and reaction time of the four groups were measured using the oddball task and compared to explore the differences in their tone categorical perception ability.ResultsConsidering both between-tone category and within-tone category, the three music groups showed both greater accuracy and shorter reaction times than the non-music group. Regarding the three music groups, no significant differences in accuracy and reaction time were detected between the instrumental and vocal groups. However, the instrumental vocalist group outperformed both the instrumental and vocal groups in terms of accuracy and reaction time.DiscussionResults showed that music training seems to have a positive effect on the categorical perception of Mandarin tone categories in Chinese dialect areas, and demonstrated that the combination of instrumental and vocal music training can further enhance tone categorical perception. To some extent, these findings provide a theoretical basis for the improvement of individual tone perception ability in dialect areas, and provided theoretical support for music and language education.
Associations of bone mineral density with sex hormone-binding globulin (SHBG) and testosterone in middle-aged Saudi men: a cross-sectional study
Authors: Yakout Sobhy M. , Khattak Malak Nawaz Khan , Al-Daghri Nasser M. , Al-Masri Abeer A. , Elsaid Mohamed A. 
Published: November 2023

ObjectiveThe present cross-sectional study examined the association between circulating levels of sex hormone-binding globulin (SHBG) and testosterone with bone mineral density (BMD) in middle-aged Arab men.MethodsClinical data of 103 middle-aged Saudi men (mean age 60.7±7.2) were extracted from the Osteoporosis Registry of the Chair for Biomarkers of Chronic Diseases, King Saud University in Riyadh, Saudi Arabia. Participants were categorized according to the presence of osteopenia (T-score -1.0 to -2.5) (N=47) and controls (N=56). Data collected included demographics and anthropometrics as well as levels of sex hormone-binding globulin (SHBG), testosterone and follicle-stimulating hormone (FSH) which were measured using commercially available assays. Free androgen index (FAI) was calculated.ResultsThose with osteopenia had significantly lower levels of FAI (p&lt;0.05), and higher levels of SHBG (p&lt;0.004) and FSH (p&lt;0.005). In the osteopenia group, SHBG was positively correlated with age (r=0.33, p&lt;0.05), while it was inversely correlated with BMD spine (r = -0.39, p&lt;0.05) and T-score femur (r= -0.35, p&lt;0.05) in the same group. Furthermore, testosterone was inversely correlated with BMI in the osteopenia group (r= -0.33, p&lt;0.05) while FAI was positively correlated with T-score femur (r = 0.36, p&lt;0.05) as well as in all participants (r= 0.24, p&lt;0.05). Among controls, FAI had an inverse correlation with FSH (r= -0.28, p&lt;0.05) and over-all (r= -0.22, p&lt;0.05).ConclusionIn summary, the associations elicited suggest that circulating levels of SHBG and FAI may be against age-related bone loss in middle-aged men.
Association between body composition and the risk of mortality in the obese population in the United States
Authors: Lee Heeso , Chung Hye Soo , Kim Yoon Jung , Choi Min Kyu , Roh Yong Kyun , Yu Jae Myung , Oh Chang-Myung , Kim Joon , Moon Shinje 
Published: November 2023

BackgroundRecent studies have presented the concept of the obesity paradox, suggesting that individuals with obesity have a lower risk of death than those without obesity. This paradox may arise because body mass index (BMI) alone is insufficient to understand body composition accurately. This study investigated the relationship between fat and muscle mass and the risk of mortality in individuals with overweight/obesity.MethodsWe used data from the National Health and Nutrition Examination Survey (NHANES) from 1999 to 2006 and 2011 to 2018, which were linked to mortality information obtained from the National Death Index. Multiple Cox regression analyses were performed to estimate mortality risk. Subgroup analysis was conducted using propensity score-matched (PSM) data for age, sex, and race/ethnicity.ResultsThis study included 16,555 participants who were overweight/obese (BMI≥25 kg/m2). An increase in appendicular skeletal muscle mass index was associated with a lower mortality risk (hazard ratio [HR]: 0.856; 95% confidence interval [CI]: 0.802–0.915). This finding was consistent with the subgroup analysis of the PSM data. Contrastingly, a high fat mass index was associated with an increased risk of mortality. Sarcopenic overweight/obesity was significantly associated with high mortality compared to obesity without sarcopenia (HR: 1.612, 95%CI: 1.328–1.957). This elevated risk was significant in both age- and sex-based subgroups. This finding was consistent with the subgroup analysis using PSM data.ConclusionIn contrast to the obesity paradox, a simple increase in BMI does not protect against mortality. Instead, low body fat and high muscle mass reduce mortality risk.
Body composition and testosterone in men: a Mendelian randomization study
Authors: Ikehata Yoshihiro , Hachiya Tsuyoshi , Kobayashi Takuro , Ide Hisamitsu , Horie Shigeo 
Published: November 2023

BackgroundTestosterone is an essential sex hormone that plays a vital role in the overall health and development of males. It is well known that obesity decreases testosterone levels, but it is difficult to determine the causal relationship between body composition and testosterone.MethodsTo investigate potential causal associations between body composition and testosterone levels by a first time application of Mendelian randomization methods. Exposure variables in men included body composition (fat mass, fat-free mass, and body mass index). In addition to whole body fat and fat-free mass, we examined fat and fat-free mass for each body part (e.g., trunk, left arm, right arm, left leg and right leg) as exposures. Instrumental variables were defined using genome-wide association study data from the UK Biobank. Outcome variables in men included testosterone levels (total testosterone [TT], bioavailable testosterone [BT], and sex hormone-binding globulin [SHBG]). A one-sample Mendelian randomization analysis of inverse-variance weighted and weighted median was performed.ResultsThe number of genetic instruments for the 13 exposure traits related to body composition ranged from 156 to 540. Genetically predicted whole body fat mass was negatively associated with TT (β=-0.24, P=5.2×10-33), BT (β=-0.18, P=5.8×10-20) and SHBG (β=-0.06, P=8.0×10-9). Genetically predicted whole body fat-free mass was negatively associated with BT (β=-0.04, P=2.1×10-4), but not with TT and SHBG, after multiple testing corrections. When comparing the causal effect on testosterone levels, there was a consistent trend that the effect of fat mass was more potent than that of fat-free mass. There were no differences between body parts.ConclusionThese results show that reducing fat mass may increase testosterone levels.
Humoral antibody response following mRNA vaccines against SARS-CoV-2 in solid organ transplant recipients; a status after a fifth and bivalent vaccine dose
Authors: Christophorou Emma , Nilsson Anna Christine , Petersen Inge , Lindvig Susan O. , Davidsen Jesper R. , Abazi Rozeta , Poulsen Mikael K. , Pedersen Rune M. , Justesen Ulrik S. , Johansen Nicolai E. , Bistrup Claus , Madsen Lone W. , Johansen Isik S. 
Published: November 2023

BackgroundIn solid organ transplant (SOT) recipients, the humoral response following COVID-19 vaccination is reduced, as a result of their immunosuppressed treatment. In this study, we investigated antibody concentrations after booster vaccinations until the fifth dose, the latter by monovalent or bivalent BA1 or BA4/5 vaccines. In addition, we evaluated the efficacy of vaccination by recording breakthrough infections, hospitalizations, and deaths.MethodThis prospective cohort study included 438 SOT recipients (&gt;18 years) vaccinated with mRNA vaccines against COVID-19 from January 2021 until March 2023. Blood samples were drawn before and after each vaccination and tested for SARS-CoV-2 spike RBD IgG antibodies with the lowest and highest cut-off at 7.1 and 5,680 BAU/mL, respectively. Vaccine information, breakthrough infections, and hospitalizations were collected from the medical records.ResultsMost participants received BNT162b2 and 61.4% received five vaccine doses. The response proportion in SOT recipients increased from 86.7% after the fourth dose to 93.0% following the fifth dose. Antibody concentration decreased with 142.7 BAU/mL between the third and fourth dose (median 132 days, Quartile 1: 123, Quartile 3: 148) and 234.3 BAU/mL between the fourth and fifth (median 250 days, Quartile 1: 241, Quartile 3: 262) dose among those without breakthrough infection (p=0.34). When comparing the Omicron BA.1 or Omicron BA.4/BA.5 adapted vaccines, no significant differences in antibody concentration were found, but 20.0% of SOT recipients receiving a monovalent fifth vaccine dose had a breakthrough infection compared to 4.0% and 7.9% among those who received BA.1 and BA.4/BA.5 adapted vaccines, respectively (p=0.04). Since January 2021, 240 (54.8%) participants had a breakthrough infection, and 22 were hospitalized, but no deaths were observed.ConclusionsThe fifth COVID-19 vaccine dose raised antibody response to 93.0% of the study population. Additional booster doses, as well as bivalent vaccines, led to higher levels of antibody concentration in SOT recipients. We found a lower incidence of breakthrough infections among SOT recipients after receiving a bivalent vaccine as a fifth dose compared to those receiving a monovalent dose. Antibody concentrations did not wane when the time between doses was prolonged from four to eight months.