bluuebunny/crossref_metadata_2025_split huggingface dataset:
Cardiorenal protective effects of extracts of bitter leaf (Vernonia amygdalina) in animal model of metabolic syndrome
Authors: Uchendu Ikenna K. , Ikebunwa Obinna A. , Okpagu Chidimma 
Published: November 2023

Every year, metabolic syndrome and cardiorenal diseases cause many deaths worldwide. African bitter leaf (Vernonia amygdalina) is known for its numerous therapeutic effects. Potentially, it can lower plasma lipid and glucose levels, which, in turn, may improve the condition of patients with the abovementioned diseases. This research featured the antihyperlipidemic and antihyperglycemic effects of methanol extract of V. amygdalina in an animal model of metabolic syndrome.
Twenty albino rats were divided into four groups. Groups A to C were orally administered with ghee (3 mL/kg) + high-cholesterol diet (500 mg/kg) + high-sugar diet (10 mL/kg) to induce metabolic syndrome. Group A served as negative control and received no treatment with bitter leaf methanol extract. Groups B and C received 200 and 400 mg/kg of V. amygdalina methanol extract, respectively. Group D received no administration. The cardiorenal injuries and alterations in blood lipids and sugar levels wereassessed via various biochemical analyses.
The combination of ghee + high-cholesterol diet + high-sugar diet triggered a significant elevation of creatine kinase myocardial band, lactate dehydrogenase, aspartate aminotransferase, triglycerides, total cholesterol, low density lipoprotein-cholesterol, glucose, urea, creatinine, and potassium levels. The histopathological results agreed with the biochemical findings. However, the treatment with 200 and 400 mg/kg of V. amygdalina methanol extract was able to inhibit the adverse alterations causing a dosedependent significant antihyperlipidemic and antihyperglycemic effect (p < 0.05).
Bitter leaf (V. amygdalina) demonstrated cardiorenal protective effects and may be used to manage metabolic syndrome.
Performance indicators to characterize the water supply to meet the demands of the Lurin River Basin
Authors: Olortegui Artica Christiand , Paredes Arquiola Javier , Ramos Fernández Lia , Cruz Grimaldo Camila Leandra , Salazar Coronel Wilian , Flores del Pino Lisveth 
Published: November 2023

Abstract

Water scarcity and the planning of socioeconomic activities are challenges in the management of water resources. Therefore, the objective of this study was to use reliability indicators (RI) to simulate management scenarios in the Lurin River Basin. First, flow rates for the period 1969–2019 were calculated using the EvalHid HBV hydrological model and SIMGES, both from the AQUATOOL decision support system, to simulate demands. The estimation of agricultural demand IRs was made under three conditions: that the deficits for one, two, and 10 years should not exceed 20–40, 40–60, and 80–100% of the annual demand. The goodness-of-fit indices obtained for flow calibration were 0.716, 0.89, and 0.901 for Nash index (NSE), Nash natural logarithm (Ln NSE), and Pearson's correlation coefficient (R), representing the values of satisfactory, very good, and good, respectively. Agricultural demands present annual deficits of 59–96, 92–138, and 333–688% for one, two, and 10 years, so a 50 m3 reservoir is proposed to meet the IR. Thus, the information generated could be used to improve water resource management in the Lurin Basin.
Impact of targeted subsidies on access to resilient sanitation for climate-vulnerable households in rural Cambodia
Authors: Kozole Tyler , Ross Marlaina , Nicoletti Chris , Rogla Jennifer , Ives Nate , Ali Amjad , Prom Ratsamnang 
Published: November 2023

Abstract
Access to safe sanitation is a basic requirement for human well-being and is critical for protecting public health and preventing environmental contamination at the community level. The increasing global risk of climate-related disasters exacerbates the likelihood of traditional sanitation solutions failing and exposing communities to harmful pathogens. This risk is ubiquitous in Cambodia's flood-prone Tonle Sap Lake region, which has some of the lowest rates of sanitation coverage in the country. This study sought to design and test a targeted mechanism in the region to deliver sanitation subsidies to households in a vulnerable position due to climate and socioeconomic characteristics. Subsidy eligibility was evaluated using the poverty probability index for Cambodia, with thresholds set according to households' individual and community-level climate vulnerability. In a randomized controlled trial, offering subsidies increased the likelihood of successful sales conversions for climate-resilient latrine products among targeted households by 32 percentage points, indicating effectiveness for increasing market-based sanitation uptake. The research did not find evidence of widespread or sustained market distortion due to the subsidy program.
Application of oak charcoal-based activated carbon for the removal of methylene blue dye from aqueous solutions: kinetics, equilibrium, and reusability studies
Authors: Kouhi Kosar , Amouei Abdoliman , Asgharnia Hosseinali , Vosoughi Mehdi , Fallah Seyede Houriye , Shirmardi Mohammad 
Published: November 2023

Abstract

The present study investigated the use of oak charcoal-based activated carbon (OC-AC) as an adsorbent for the removal of methylene blue (MB) dye from aqueous solutions. The study examined the effects of key operational variables, including pH, equilibrium time, adsorbent dosage, and initial dye concentration. The results showed that pH had no significant effect on MB adsorption for the initial MB concentration below 50 mg L−1 and an adsorbent dosage of 1 g L−1, but increasing the contact time and adsorbent dosage improved the removal efficiency. For instance, at an initial MB concentration of 50 mg L−1, the removal percentage increased from 76 to 99.9%, with increasing adsorbent dosage from 0.5 to 3 g L−1. In addition, with increasing contact time from 5 to 300 min, the removal percentage increased from 45.43 to 87.42%. The study also analyzed the kinetics and isotherm behavior of MB adsorption and found that the Avrami fractional order kinetic model and the Freundlich isotherm model provided the best fit for the experimental data. MB removal from real water samples showed that OC-AC could be used as an efficient and environmentally friendly adsorbent for removing MB dye from contaminated effluents with the removal percentage ranging from 83 to 97%.
Ferroptosis Inducers as Promising Radiosensitizer Agents in Cancer
Radiotherapy
Authors: Zefrei Fatemeh-Jalali , Shormij Mohammd , Dastranj Leila , Alvandi Maryam , Shaghaghi Zahra , Farzipour Soghra , Zarei-Polgardani Nasim 
Published: November 2023

Abstract:
Radiotherapy (RT) failure has historically been mostly attributed to radioresistance.
Ferroptosis is a type of controlled cell death that depends on iron and is caused by polyunsaturated
fatty acid peroxidative damage. Utilizing a ferroptosis inducer may be a successful tactic
for preventing tumor growth and radiotherapy-induced cell death. A regulated form of cell death
known as ferroptosis is caused by the peroxidation of phospholipids containing polyunsaturated
fatty acids in an iron-dependent manner (PUFA-PLs). The ferroptosis pathway has a number of
important regulators. By regulating the formation of PUFA-PLs, the important lipid metabolism
enzyme ACSL4 promotes ferroptosis, whereas SLC7A11 and (glutathione peroxidase 4) GPX4
prevent ferroptosis. In addition to introducing the ferroptosis inducer chemicals that have recently
been demonstrated to have a radiosensitizer effect, this review highlights the function and
methods by which ferroptosis contributes to RT-induced cell death and tumor suppression in
vitro and in vivo.
Zingiber Officinale-assisted Graphene Oxide Green Reduction for
Excellent Photocatalysis
Authors: Saini Krati , Chamoli Pankaj , Shukla Ravi K. , Kar Kamal K. , Raina K. K. 
Published: November 2023

Introduction:
A facile approach for producing graphene nanosheets (GNs) has been established
by reducing graphene oxide (GO) with ginger extract (GEx) at low temperature. The elimination
of oxygen characteristics from GO has been validated by a Raman study.

Method:
FTIR analysis also supports the Raman signatures of the removal of oxygen species from
the carbon core. Surface analysis confirms the remarkable deoxidation of GO and settles the production
of GNs. After that, synthesized GNs were tested for their capability to photodegrade Methylene
blue (MB) dye under visible and UV (both 125 W) light.

Result:
At low concentrations (0.5 mg), GNs are an effective photocatalyst for the degradation of
MB, with a maximum degradation efficiency of 91.84% in 45 minutes when exposed to UV light
irradiation.

Conclusion:
Results favor that the GEx provides a potential substitute for toxic or harmful reducing
agents for the ecologically sustainable production of GNs on a mass scale and synthesized GNs act
as an excellent photocatalyst against MB.
A Review: Bilosomes as Nanocarriers
Authors: Sharma Bhawna , Chauhan Iti 
Published: November 2023

:
Liposomes and niosomes, two vesicular carriers that are prospective candidates for
drug delivery, have been used in numerous formulations. New research in this area has led to the
development of a ‘niosome-like’ colloidal carrier termed bilosomes. Bilosomes have been
designed as prospective vesicular carriers to deliver targeted drugs via parenteral, transdermal,
and oral routes.

:
These innovative vesicular systems, based on bile salts, have been discussed in detail in the
current review. The review addresses the composition of bilosomes, their creation and
characterization processes. Previous research on bilosomes has been compiled, along with their
applications and advantages over more traditional nanocarriers such as liposomes and niosomes.
It also emphasizes the utilization of bilosomes and their stability.
Development of Niosomal Vesicles Loaded Mometasone Furoate Gel for Transdermal Delivery and its Evaluation
Authors: Rane Bhushan R. , Chavan Pushkar Y. , Kate Nidhi S. , Jain Ashish S. 
Published: November 2023

Background:Mometasone Furoate (MF) is a corticosteroid (glucocorticoid) used to treat eczema, psoriasis, allergies, and rash on the skin; also used to reduce itching, redness, and swelling (inflammation). It has been reported that the bioavailability of MF is less than 11% when given via the nasal route. Encapsulating the drug in niosomes can improve the active pharmaceutical ingredient's bioavailability by enhancing both physical and biological stability.Objective:The goal of the study is to develop, a non-ionic surfactant-based vesicular system, by loading mometasone furoate, and introducing it into a gel-based formulation by utilizing an appropriate gelling agent, and performing its evaluation.Methods:The niosome vesicle was prepared by vacuum rotary evaporation method (Thin film hydration method). Gel was prepared using the dispersion method and in-vitro drug diffusion studies using Franz-diffusion cells.Result:According to the results of the experiments conducted for the study, Mometasone Furoate niosomal gel was prepared utilizing Mometasone Furoate niosomes that were made using the thin film hydration process, Cholesterol, and Span 60, and loaded in various amounts of Carbopol as a geling agent. The niosomes' zeta potential was found to be -24 mV, showing that the formulation is stable. The polydispersity index (PDI) was found to be 0.409 and the average size of niosomes to be 252.7 nm. The performance of the gel of the optimized formulations containing 2% Carbopol showed in vitro diffusion for 7 hours and an increased flux rate as compared to the plain MF.Conclusion:The experiments carried out during the study led to the conclusion that the thin-film hydration method was suitable for the formation of the MF-niosomes by using Span 60 and Cholesterol (2:1). The gel formulation containing 2% Carbopol indicated better in vitro diffusion following the Higuchi model across all niosomal gel formulations. Niosomal gel can be regarded as the best vesicular carrier for the efficient distribution of mometasone furoate via the transdermal route.
Produção científica e académica da Universidade do Minho 1976-2022: Contributos para o seu estudo
Authors: Rodrigues Eloy , Saraiva Ricardo , Cardoso Edward , Correia Antónia , Luís Ana Rita 
Published: November 2023

O presente trabalho, enquadrado nas comemorações do 50º aniversário da Universidade do Minho (UMinho), pretende contribuir para um conhecimento mais completo e detalhado do conjunto da produção científica e académica da Universidade desde a sua criação, sendo constituído por duas partes. Na primeira apresentam-se a analisam-se brevemente os dados coligidos no Inventário das publicações e académicas da autoria de membros da Universidade do Minho entre 1976 e 2022, incluindo também uma análise das publicações disponíveis no RepositóriUM. A segunda parte é uma análise mais detalhada da produção científica da Universidade do Minho, igualmente entre 1976 e 2022, indexada na Web of Science, posicionando-a também no contexto da produção científica de Portugal ao longo deste período.
Digital Medical Information Services Delivered by Pharmaceutical Companies via WeChat: Qualitative Analytical Study
Authors: Ge Ying , Yao Dongning , Ung Carolina Oi Lam , Xue Yan , Li Meng , Lin Jiabao , Hu Hao , Lai Yunfeng 
Published: November 2023

Background
Social media has become one of the primary information sources for medical professionals and patients. Pharmaceutical companies are committed to using various social media platforms to provide stakeholders with digital medical information services (DMISs), which remain experimental and immature. In China, WeChat tops the list of popular social media platforms. To date, little is known about the service model of DMISs delivered by pharmaceutical companies via WeChat.

Objective
This study aims to explore the emerging service model of DMISs delivered by pharmaceutical companies via WeChat in China.

Methods
This study applied a qualitative research design combining case study and documentary analysis to explore the DMISs of 6 leading pharmaceutical companies in China. Materials were collected from their official WeChat platforms. Thematic analysis was conducted on the data.

Results
The DMISs of 6 pharmaceutical companies were investigated. Themes emerged regarding 2 essential information services delivered by pharmaceutical companies via WeChat: business operation services and DMISs (ie, public information services, professional services, science and education services, and e-commerce services). Business operation services mainly function to assist or facilitate the company’s operations and development trends for general visitors. Public-oriented information services are realized through health science popularization, academic frontiers, product information, and road maps to hospitals and pharmacies. Internet hospital and pharmacy services are the main patient-oriented professional services. Medical staff–oriented science and education services commonly include continuing education, clinical assistance, academic research, and journal searching. Public-oriented e-commerce services include health products and health insurance.

Conclusions
Pharmaceutical companies in China use WeChat to provide stakeholders with diversified DMISs, which remain in the exploratory stage. The service model of DMISs requires more distinct innovations to provide personalized digital health and patient-centric services. Moreover, specific regulations on the DMISs of pharmaceutical companies need to be established to guard public health interests.
Behavioral Mechanisms That Mediate Mental and Physical Health Improvements in People With Chronic Pain Who Receive a Digital Health Intervention: Prospective Cohort Pilot Study
Authors: Cheng Abby L , Agarwal Mansi , Armbrecht Melissa A , Abraham Joanna , Calfee Ryan P , Goss Charles W 
Published: November 2023

Background
Preliminary evidence suggests that digital mental health intervention (Wysa for Chronic Pain) can improve mental and physical health in people with chronic musculoskeletal pain and coexisting symptoms of depression or anxiety. However, the behavioral mechanisms through which this intervention acts are not fully understood.

Objective
The purpose of this study was to identify behavioral mechanisms that may mediate changes in mental and physical health associated with use of Wysa for Chronic Pain during orthopedic management of chronic musculoskeletal pain. We hypothesized that improved behavioral activation, pain acceptance, and sleep quality mediate improvements in self-reported mental and physical health.

Methods
In this prospective cohort, pilot mediation analysis, adults with chronic (≥3 months) neck or back pain received the Wysa for Chronic Pain digital intervention, which uses a conversational agent and text-based access to human counselors to deliver cognitive behavioral therapy and related therapeutic content. Patient-reported outcomes and proposed mediators were collected at baseline and 1 month. The exposure of interest was participants’ engagement (ie, total interactions) with the digital intervention. Proposed mediators were assessed using the Behavioral Activation for Depression Scale–Short Form, Chronic Pain Acceptance Questionnaire, and Athens Insomnia Scale. Outcomes included Patient-Reported Outcomes Measurement Information System Anxiety, Depression, Pain Interference, and Physical Function scores. A mediation analysis was conducted using the Baron and Kenny method, adjusting for age, sex, and baseline mediators and outcome values. P<.20 was considered significant for this pilot study.

Results
Among 30 patients (mean age 59, SD 14, years; 21 [70%] female), the mediation effect of behavioral activation on the relationship between increased intervention engagement and improved anxiety symptoms met predefined statistical significance thresholds (indirect effect –0.4, 80% CI –0.7 to –0.1; P=.13, 45% of the total effect). The direction of mediation effect was generally consistent with our hypothesis for all other proposed mediator or outcome relationships, as well.

Conclusions
In a full-sized randomized controlled trial of patients with chronic musculoskeletal pain, behavioral activation, pain acceptance, and sleep quality may play an important role in mediating the relationship between use of a digital mental health intervention (Wysa for Chronic Pain) and improved mental and physical health.

Trial Registration
ClinicalTrials.gov NCT05194722; https://clinicaltrials.gov/ct2/show/NCT05194722
Analytical Review of Medadhatudushti in Prameha
Authors: Sharma Ketan , Kumari Shailza , Veena Veena , Raghuwanshi Manoj Singh 
Published: November 2023

Prameha is a lifestyle disorder, described in ancient medical science. It is a sannipataja disorder having predominance of kaphadosha and medodhatudushti. It is produced by the vitiation of ten dusya which include six dhatu, ojus and body fluids. Among ten dusya meda is prime dusya because of similar nature of kapha and meda. Various factors i.e. aharaja and viharaja nidana, increase kapha dosha which in turn vitiates medodhatu. Vitiated kapha affects the medovahasrotasa and medodharakala. Medadhatwaagni gets degraded resulting into improper formation of medadhatu. The abnormal medadhatu is responsible for obesity and prameha. It leads to the manifestation of many purvarupa of prameha & ultimately prabhutaavila mutrata. Assessment of medadusthi is very important for the early diagnosis and proper treatment of prameha.
Keywords: Prameha, Medadhatu, Medadhatwaagni, Medadhatudushti
Associations of Electrocardiographic Abnormalities in Stable Type 2 Diabetes Subjects: Experience from a Tertiary Health Facility in South Eastern Nigeria
Authors: Ezeude CM , Nkpozi MO , Abonyi MC , Onwuegbuna AA , Okechukwu UC , Anyanwu AC , Ikeabbah HE , Ezeude AM 
Published: November 2023

Introduction: Cardiovascular abnormalities are prevalent in the setting of diabetes mellitus, even among stable subjects, necessitating the need for a regular cardiovascular disease screening for this group of patients. Electrocardiogram is a simple and reliable screening test for cardiovascular abnormalities that could be easily accessible even in resource poor and rural settings. This study was carried out to determine the association between cardiovascular risk factors and electrocardiographic abnormalities in stable type 2 diabetes subjects in South Eastern Nigeria.
Materials and Methods: One hundred and thirty-six stable adults with type 2 diabetes mellitus were recruited consecutively from the out-patient diabetes clinic of Nnamdi Azikiwe University Teaching Hospital in South Eastern Nigeria. They were assessed for the risk factors for cardiovascular diseases that included smoking, obesity, dyslipidaemia, poor glycaemic control, hypertension, lack of exercise, presence of chronic kidney disease and metabolic syndrome. They also had a 12 lead electrocardiogram done. Results were analyzed using SPSS version 25. P value of ˂ 0.05 was considered significant.
Result: A total of 128 subjects had complete results and were analyzed. There were 63 males and 65 females with a mean age of 58.43 ± 12.85 years and mean diabetes duration of 9.03 ± 7.36 years. A total of 45.3% of the subjects had electrocardiographic abnormalities. Hypertension was present in 54.9%, dyslipidaemia in 91.4%, central obesity in 74.3%, metabolic syndrome in 76.6% and chronic kidney disease in 57.9% of the subjects. Significant association was found between smoking and occurrence of AV block (p = 0.008), central obesity and QRS axis abnormality (p = 0.002), dyslipidaemia and ST segment abnormality (p = 0.001) and lack of exercise and ST segment abnormality (p = 0.000). No significant association was found between age, sex of the subjects, duration of DM, treatment modality for DM, level of glycaemic control, hypertension, presence of CKD and metabolic syndrome and any of the electrocardiographic abnormalities.
Conclusion: Electrocardiographic abnormalities are common in stable type 2 diabetic subjects. There was significant association between smoking habit, central obesity, dyslipidaemia, lack of exercise and ECG abnormalities that included AV block, QRS axis and ST segment abnormalities.
Association between Helicobacter pylori and Diabetes Mellitus
Authors: Moalim Nadar Bashir , Ali Abdelhakam H. , Elsheikh Eslam G. , Ali Dalal B. , Adam Ahmed A. 
Published: November 2023

Background: H. pylori is a gram-negative, spiral shaped, Microaerophile pathogenic bacterium that specifically colonizes on the gastric epithelium, it is one of the most common human bacterial pathogens and is the main etiological factor for peptic ulcer disease, simple gastritis and gastric malignancy. The immune status of diabetic patients is compromised, which may lead to an increased susceptibility to H. pylori infection. The aim of this study is to assess Association between Helicobacter pylori and Diabetes Mellitus.
Methods and Material: This was a cross-sectional study with 102 diabetic patients (both IDDM and NIDDM). H.pylori was assessed through the determination of stool antigen by Immunochromatography.
Results: Out of 102 samples were collected from diabetic patients, 58 were male and 44 were female. 52.9% of them are positive for H.pylori and 47.1% are negative. The mean ages of H.pylori positive patients were 44.01 years where the mean age of negative patients were 42.47 years. There was a statistically significance association (p=0.007) between the diabetes and H.Pylori infection, also there was association between history of GIT disorder and H. pylori infection, between smoking and H. pylori infection.
Conclusion: The study showed that Helicobacter pylori infection was significantly higher in diabetes Mellitus.
Keywords: H.pylori, Diabetes Mellitus, T1DM, T2DM