bluuebunny/crossref_metadata_2025_split huggingface dataset:
Association between prenatal and childhood PM2.5 exposure and preadolescent anxiety and depressive symptoms
Authors: McGuinn Laura A. , Gutiérrez-Avila Iván , Rosa Maria José , Just Allan , Coull Brent , Kloog Itai , Ortiz Marcela Tamayo , Harari Homero , Martinez Sandra , Osorio-Valencia Erika , Téllez-Rojo Martha Maria , Klein Daniel N. , Wright Rosalind J. , Wright Robert O. 
Published: December 2023

Background:
Fine particulate matter (PM2.5) exposure has been linked to anxiety and depression in adults; however, there is limited research in the younger populations, in which symptoms often first arise.

Methods:
We examined the association between early-life PM2.5 exposure and symptoms of anxiety and depression in a cohort of 8–11-year-olds in Mexico City. Anxiety and depressive symptoms were assessed using the Spanish versions of the Revised Children’s Manifest Anxiety Scale and Children’s Depression Inventory. Daily PM2.5 was estimated using a satellite-based exposure model and averaged over several early and recent exposure windows. Linear and logistic regression models were used to estimate the change in symptoms with each 5-µg/m3 increase in PM2.5. Models were adjusted for child’s age, child’s sex, maternal age, maternal socioeconomic status, season of conception, and temperature.

Results:
Average anxiety and depressive symptom T-scores were 51.0 (range 33–73) and 53.4 (range 44–90), respectively. We observed consistent findings for exposures around the fourth year of life, as this was present for both continuous and dichotomized anxiety symptoms, in both independent exposure models and distributed lag modeling approaches. This window was also observed for elevated depressive symptoms. An additional consistent finding was for PM2.5 exposure during early pregnancy in relation to both clinically elevated anxiety and depressive symptoms, this was seen in both traditional and distributed lag modeling approaches.

Conclusion:
Both early life and recent PM2.5 exposure were associated with higher mental health symptoms in the child highlighting the role of PM2.5 in the etiology of these conditions.
Mpox Knowledge and Vaccine Willingness Among a Representative Analysis of Adults in Pennsylvania
Authors: Pinto Casey N. , Risher Kathryn A. , Calo William A. , Kraschnewski Jennifer L. , Heilbrunn Emily , Paules Catharine I. 
Published: December 2023

Background
Little has been reported about mpox knowledge and vaccine willingness. We sought to collect timely data on mpox knowledge, perceived risk, and vaccine willingness among a representative sample of Pennsylvania adults.

Methods
A cross-sectional web-based survey was conducted in September 2022. Four survey items were included to assess the population's knowledge and risk awareness surrounding the current mpox outbreak, and vaccine willingness if at risk for mpox. Data analyses included descriptive statistics and logistic regressions.

Results
Among 1039 survey respondents, few reported “no knowledge of mpox symptoms” (14.2%) or transmission modalities (12.5%). Those who perceived themselves at moderate/high risk were more likely to report knowing mpox symptoms (adjusted odds ratio [aOR] = 2.12) vs no risk. Men who have sex with men were more likely to know that mpox can mimic a sexually transmitted infection (aOR = 3.125), less likely to report not knowing any modes of transmission (aOR = 0.17), and more willing to be vaccinated (aOR = 4.35) than women who have sex with men. Self-perceived mpox risk was associated with willingness to get vaccinated (aOR low risk vs no risk = 3.45 [2.42–4.92], aOR moderate/high risk vs no risk = 9.93 [5.81–16.99]).

Conclusions
Knowledge of mpox symptoms and transmission is strong in Pennsylvania, specifically among high-risk groups, but lacks a nuanced understanding specific to the current outbreak. Willingness to receive an mpox vaccine is highest in men who have sex with men and those that perceive themselves to be at highest risk. These findings highlight the need for more education on symptoms of the current outbreak and research on impact of the education on vaccine hesitancy.
Family-Centered Care Across Thai Neonatal Intensive Care Units
Authors: Vetcho Siriporn , Cooke Marie , Petsky Helen , Saito Amornrat , Ullman Amanda J. 
Published: December 2023

Background:
Implementing family-centered care (FCC) presents challenges to parental-healthcare provider partnership and collaboration in newborn care in neonatal intensive care units (NICUs).

Aims:
To explore NICU nurses' perceptions of FCC (respect, collaboration, and support) during the COVID-19 pandemic and to compare these between nurses working in secondary and tertiary/higher care settings.

Methods:
A multicenter, cross-sectional exploratory online survey design study was conducted to identify Thai NICU nurses' perceptions. The online survey of the Perceptions of Family-Centered Care—Staff (PFCC-S) was distributed via a Web page and professional networks between July and September 2022.

Results:
Of the 187 survey respondents, most NICU nurses worked in the NICU for less than 16 years and were employed in tertiary care/higher care settings in southern Thailand. There was a significant difference in perceptions of support subscale between NICU nurses in secondary (mean: 3.32, SD ± 0.53) and tertiary/higher care settings (mean: 3.17, SD ± 0.46) (P < .05).

Conclusion:
Despite the challenges of the visitation restriction of COVID-19 in Thailand, nurses' perceptions of the value of FCC were maintained.

Relevance to Clinical Practice:
Further research is recommended to investigate how FCC can be implemented where there is a lack of material and infrastructure resources and staff shortage.
Mechanism of Huaiqihuang in treatment of diabetic kidney disease based on network pharmacology, molecular docking and in vitro experiment
Authors: Wang Junwei , Ma Guiqiao , Zhang Peipei , Ma Chaojing , Shao Jing , Wang Liping , Ma Chanjuan 
Published: December 2023

Background:
This study aimed to investigate the active components, key targets, and potential molecular mechanisms Huaiqihuang (HQH) in the treatment of diabetic kidney disease (DKD) through network pharmacology, molecular docking, and in vitro experiments.

Methods:
The active components and potential targets of HQH were obtained from the TCMSP and HERB databases. The potential targets of DKD were obtained from the GeneCards, OMIM, DrugBank, and TTD databases. Protein interaction relationships were obtained from the STRING database, and a protein interaction network was constructed using Cytoscape software. Gene ontology and Kyoto Encyclopedia of Genes and Genomes enrichment analysis was performed using the Metascape database. Molecular docking was performed using AutoDock software to verify the binding between key compounds and core target genes. In vitro experiments were conducted using human renal proximal tubular epithelial cells and various methods, such as CCK8, RT-PCR, immunofluorescence, and western blot, to evaluate the effects of HQH on inflammatory factors, key targets, and pathways.

Results:
A total of 48 active ingredients, 168 potential targets of HQH, and 1073 potential targets of DKD were obtained. A total of 118 potential targets, 438 biological processes, and 187 signal pathways were identified for the treatment of DKD. Gene ontology and Kyoto Encyclopedia of Genes and Genomes analysis indicated that HQH may exert its therapeutic effects on DKD by regulating the expression of inflammatory factors through the nuclear factor kappa B (NF-κB) signaling pathway. The molecular docking results showed that β-sitosterol and baicalein had the highest binding affinity with key targets such as AKT1, IL6, TNF, PTGS2, IL1B, and CASP3, suggesting that they may be the most effective active ingredients of HQH in the treatment of DKD. In vitro experimental results demonstrated that HQH could enhance the viability of human renal proximal tubular epithelial cells inhibited by high glucose, decrease the levels of AKT1, TNF, IL6, PTGS2, IL1B, and CASP3, reduce the expression of NF-κB-P65 (P < .01), inhibit NF-κB-p65 nuclear translocation, and decrease chemokine expression (P < .01).

Conclusion:
HQH may exert its therapeutic effects on DKD by inhibiting the NF-κB signaling pathway, reducing the level of pro-inflammatory cytokines, and alleviating the high glucose-induced injury of renal tubular epithelial cells.
Atypical cutaneous presentation of AOSD with persistent itchy urticaria: A case report
Authors: Lou Jingfeng , Zhang Xingping 
Published: December 2023

Rationale:
Adult-onset Still’s disease (AOSD) is a rare multisystem disorder considered a complex autoinflammatory syndrome. The clinical and biological features of AOSD typically include a high fever with arthritic symptoms, evanescent skin rash, sore throat, striking neutrophilic leukocytosis, hyperferritinemia, and abnormal liver function. The typical rash and fever are important diagnostic clues for AOSD. Here, we report a case of atypical rash manifesting as persistent itchy urticaria.

Patient concerns:
A 57-year-old female presented with a 6-day history of fever. During her hospital stay, she progressively developed rashes that were not associated with fever, primarily distributed on her back and the distal extremities, and associated with pronounced itching. The rash was initially suspected to be urticaria; however, the patient exhibited a poor response to antihistamines. After malignancies and other rheumatic diseases were excluded, the diagnosis leaned towards AOSD based on diagnostic criteria. The patient’s fever was well controlled with the initiation of glucocorticoids, and no further rashes were observed.

Diagnoses:
Although the patient exhibited atypical rashes, after ruling out malignancies and other rheumatic diseases, she met 2 major and 3 minor criteria. Based on Yamaguchi’s criteria, the patient was diagnosed with AOSD.

Interventions:
Initially, the patient was administered an intravenous infusion of methylprednisolone at 40 mg once daily. This was later transitioned to oral administration with gradual dose reduction.

Outcomes:
Follow-up at 1 year showed no recurrence of the rash, with a stable condition and no relapse.

Lessons:
This case provides valuable insights for the early diagnosis of AOSD, emphasizing the importance of considering this diagnosis even when presenting with atypical skin rash.
Positional dyspnea due to excessive dynamic airway collapse: A case report
Authors: Sun Xiaoyan , Cui Zhenghui , Mao Yanxiong 
Published: December 2023

Rationale:
Excessive dynamic airway collapse (EDAC) is a form of dynamic central airway obstruction, with characteristic of excessive dynamic invagination of airway posterior wall membrane and structurally intact airway cartilage. We report a rare case of EDAC with a marked positional component.

Patient concerns:
A 73-year-old man was admitted to our hospital owing to dyspnea in right recumbent position (RRP). Also only in RRP, strong rhonchi was auscultated bilaterally through entire respiratory phase. He had gone through 3 episodes of resections on left lung due to hemoptysis caused by bronchiectasis, so he had only segment B1 + 2 and B3 left.

Diagnoses:
The spirometry results indicated that he had chronic obstructive pulmonary disease (COPD). The bronchoscopy revealed that in RRP, there was severe inward bulging of the posterior membrane of right main bronchus (RMB), which was worsened at expiratory phase. The EDAC of RMB was suspected, and was confirmed by an expiratory phase computed tomography (CT) in RRP. The EDAC was likely due to COPD, and the positional component was most likely to be caused by the removal of majority of his left lung.

Interventions:
Considering locality of EDAC and his overall stability, he was given a conservative approach. He was prescribed with budesonide/glycopyrrolate/formoterol for COPD and followed up.

Outcomes:
Two months later, the patient had relived dyspnea and weaker wheezing in RRP, and he had a good social and physical recovery.

Lessons:
Dyspnea may present as a diagnostic challenge, and it is rarely accompanied with a positional component. EDAC is an uncommon cause of dyspnea. This case illustrates the possible role of bronchoscopy and dynamic CT in dynamic evaluation of airway.
Bronchobiliary fistula caused after percutaneous transhepatic biliary drainage treatment: A case report
Authors: Lian Bo-Da , Zhou Wen-Yi , Peng Jiang , Zhang Xin , Zhao Kang , Chen Chen , Wang Xin-Tian , Wang Yong-Gang , He Zi-Li 
Published: December 2023

Rationale:
Percutaneous transhepatic biliary drainage (PTBD) plays a significant role especially in the diagnosis and decompression of bile duct obstruction. However, it is associated with complications such as hemobilia, occlusion of drainage, bile leakage, and even bronchobiliary fistula (BBF).

Patient concerns and diagnoses:
We herein describe a patient with a complication of BBF caused by long-term indwelling PTBD catheters. She underwent multiple operations including bilioenteric anastomosis, hepatic left lateral lobectomy, and long-term PTBD treatment. Her symptoms were mainly cough, fever, and yellow sputum and her diagnosis was confirmed by sputum culture (bilirubin detection was positive).

Interventions and outcomes:
The patient recovered uneventfully by minimally invasive treatment, was discharged after 1 week of hospitalization, and the drainage tube was removed 2 weeks later. During 2 years of follow-up, no recurrence of BBF was observed.

Lessons:
Patients with long-term indwelling PTBD catheters for biliary tract obstruction may lead to BBF. The treatment plan of BBF is tailored to the patient’s individualized characteristics. And minimally invasive treatments might be an effective alternate way for the treatment of BBF. The accurate diagnosis, precision treatment, and multidisciplinary team play important roles in the treatment of BBF.
Impact of ovary-sparing treatment planning on plan quality, treatment time and gamma passing rates in intensity-modulated radiotherapy for stage I/II cervical cancer
Authors: Huang Yangyang , Qin Tingting , Yang Menglin , Liu Zongwen 
Published: December 2023

Background:
This study aimed to investigate the impact of ovary-sparing intensity-modulated radiotherapy (IMRT) on plan quality, treatment time, and gamma passing rates for stage I/II cervical cancer patients.

Methods:
Fifteen stage I/II cervical cancer patients were retrospectively enrolled, and a pair of clinically suitable IMRT plans were designed for each patient, with (Group A) and without (Group B) ovary-sparing. Plan factors affecting plan quality, treatment time, and gamma passing rates, including the number of segments, monitor units, percentage of small-area segments (field area < 20 cm2), and percentage of small-MU segments (MU < 10), were compared and statistically analyzed. Key plan quality indicators, including ovarian dose, target dose coverage (D98%, D95%, D50%, D2%), conformity index, and homogeneity index, were evaluated and statistically assessed. Treatment time and gamma passing rates collected by IBA MatriXX were also compared.

Results:
The median ovarian dose in Group A and Group B was 7.61 Gy (range 6.71–8.51 Gy) and 38.52 Gy (range 29.84–43.82 Gy), respectively. Except for monitor units, all other plan factors were significantly lower in Group A than in Group B (all P < .05). Correlation coefficients between plan factors, treatment time, and gamma passing rates that were statistically different were all negative. Both Groups of plans met the prescription requirement (D95% ≥ 45.00 Gy) for clinical treatment. D98% was smaller for Group A than for Group B (P < .05); D50% and D2% were larger for Group A than for Group B (P < .05, P < .05). Group A plans had worse conformity index and homogeneity index than Group B plans (P < .05, P < .05). Treatment time did not differ significantly (P > .05). Gamma passing rates in Group A were higher than in Group B with the criteria of 2%/3 mm (P < .05) and 3%/2 mm (P < .05).

Conclusion:
Despite the slightly decreased quality of the treatment plans, the ovary-sparing IMRT plans exhibited several advantages including lower ovarian dose and plan complexity, improved gamma passing rates, and a negligible impact on treatment time.
Evaluation of cerebrospinal fluid levels for ALOX5, S100B, DEFA1, and GFAP in infectious meningitis
Authors: Baran Ali İrfan , Huyut Zübeyir , Öncü Mehmet Reşit , Akbay Halil İbrahim , Akmeşe Şükrü , Karsen Hasan , Alp Hamit Hakan , Hakseven Karaduman Zekiye , Tarcan Tayyar 
Published: December 2023

Background:
The aim of this study was to determine how the levels of peptide and protein-based biomarkers in cerebrospinal fluid change in bacterial, tuberculous, and aseptic meningitis, and to determine the success of these agents in distinguishing between different types of infectious meningitis.

Methods:
The levels of arachidonate-5-lipoxygenase, S100 calcium-binding protein B, defensin-α 1, and glial fibrillary acidic protein in cerebrospinal fluid samples from 20 tuberculosis, 40 bacterial, 25 aseptic meningitis patients, and 55 control groups were measured and compared using an enzyme-linked immunosorbent assay.

Results:
The mean age of the patients was 37.9 ± 14.4 years. The parameter that contributed the most to the differential diagnosis of the infectious meningitis groups was S100 calcium-binding protein B. The S100 calcium-binding protein B levels were significantly higher in the tuberculous meningitis group than in the other groups, and arachidonate-5-lipoxygenase levels were significantly higher in the tuberculous meningitis and bacterial meningitis groups (P < .05).

Conclusion:
This study showed that cerebrospinal fluid arachidonate-5-lipoxygenase, and S100 calcium-binding protein B levels may differ in bacterial, aseptic, and tuberculous meningitis, and the results obtained may be quite effective as important potential biomarkers in the differential diagnosis of different types of meningitis.
Bibliometrics and visual analysis of metformin and gut microbiota from 2012 to 2022: A systematic review
Authors: Shu Yang , Li Weidong , Hu Qiongying , Xiong Daqian 
Published: December 2023

Background:
Metformin is an old drug used for the treatment of type 2 diabetes mellitus and can play a variety of roles by regulating the gut microbiota. The number of research articles on metformin in the gut microbiota has increased annually; however, no bibliometric tools have been used to analyze the research status and hot trends in this field. This study presents a bibliometric analysis of publications on metformin and gut microbiota.

Methods:
We searched the Web of Science core collection database on June 8, 2023, for papers related to metformin and gut microbiota from 2012 to 2022. We used Microsoft Excel 2021, VOSviewer1.6.19, CiteSpace 6.2.4, and R software package “bibliometrix” 4.0.0 to analyze the countries, institutions, authors, journals, citations, and keywords of the included publications.

Results:
We included 517 papers, and the trend in publications increased over the last 11 years. The 517 articles were from 57 countries, including 991 institutions and 3316 authors, and were published in 259 journals. China led all countries (233 papers) and the most influential institution was the Chinese Academy of Sciences (16 papers). PLOS ONE (19 papers) was the most popular journal, and Nature (1598 citations) was the most cited journal. Li and Kim were the 2 most published authors (six papers each), and Cani (272 co-citations) was the most co-cited author. “Metabolites,” “aging,” and “intestinal barrier” were emerging topics in this field.

Conclusions:
This bibliometric study comprehensively summarizes the research trends and progress of metformin and gut microbiota, and provides new research topics and trends for studying the effects of metformin on gut microbiota in different diseases.
Network meta-analysis of different liver protective drugs in the treatment of drug-induced liver injury
Authors: Li Chengcheng , Yang Xin , Quan Yuhang , Wu Anhao , Wang Yifan 
Published: December 2023

Background:
Currently, drug-induced liver injury (DILI) has become one of those public issues in society, which has added a huge burden to both the individuals and the society. In the current clinical stage, there are numerous drugs developed to treat this disease, and different drug treatment measures have been proven to achieve certain clinical efficacy in the corresponding randomized controlled trials. However, there are still many therapeutic drugs that have not been directly compared and studied. Therefore, it is difficult to directly compare the effectiveness and safety of various strategies for the treatment of DILI. In this regard, the present study collected the therapeutic efficacy of diverse treatments in DILI in recent years through network meta-analysis, evaluated and screened the existing optimal clinical therapeutic plan, and helped physicians formulate clinical therapeutic plans.

Methods:
Databases, including the Chinese Journal Full-text Database, Wanfang Data Journal Paper Resources (Wangfang), VIP Chinese Science and Technology Journal Full-text Database, The Cochrane Library, PubMed, and EMBASE, were searched using keywords from inception to January 2023. Eligible randomized controlled trials were selected in line with eligibility criteria, and mesh meta-analysis of binary variables was carried out using Stata 16 software.

Conclusion:
In combination with alanine aminotransferase, aspartate aminotransferase, and total bilirubin, MI may be the intervention measure for minimizing alanine aminotransferase levels in patients after treatment. Besides, compound glycyrrhizin may be the intervention for minimizing aspartate aminotransferase levels in patients after treatment, and polyene phosphatidylcholine may be the intervention for minimizing total bilirubin levels in patients after treatment. Placebo is the potential intervention that has the least adverse reactions post-treatment, and RT has the second least adverse reactions. Moreover, hepatocyte growth-promoting factors may be the most effective intervention after treatment.

Results:
To sum up, the present work compared the clinical effects of 13 liver protective drugs through meta-analysis and provided a systematic understanding of commonly used drugs for the treatment of DILI in clinical practice.
Inflammatory myofibroblastic tumor of the upper arm: A case report
Authors: Yuan Caidi , Fan Jie , Xu Lingjia 
Published: December 2023

Rationale:
Inflammatory myofibroblastic tumor (IMT) is an uncommon benign myofibroblastic tumor that usually occurs in the lung, mediastinum, abdomen and vulvovaginal region. IMT of the upper arm is exceedingly rare with unknown etiology. Pathology plays a major role in the diagnosis of IMT, and radiological characteristics of the condition are crucial for differential diagnosis.

Patient concerns:
A 62-year-old woman was admitted to our hospital for a complaint of a mass in her left upper limb with progressive numbness in the extremity. Ultrasound examination of the brachial artery (BA) revealed a hypoechoic mass with well-defined borders and a substantial blood flow, and the mass was also shown to be greatly enhanced on computed tomography (CT) and magnetic resonance imaging (MRI).

Diagnosis:
The subsequent histopathological and immunohistochemical studies led to the diagnosis of IMT.

Intervention:
The patient was referred for surgery. The soft tissue tumor resection, left median nerve release operation, brachial artery vascular grafting, and arterial anastomosis were performed.

Outcome:
Favorable outcome was observed. The patient recovered well from the procedure and did not experience any further complications or tumor recurrence.

Lessons:
In this report, we describe a case of IMT of the upper arm with BA involvement. The case expands the differential diagnosis of limb neoplasm and broadens the understanding of its ultrasonic and radiological imaging features. It also serves as a further example of an uncommon region distinct from conventional IMT. Further studies on the etiology and therapeutic strategies are needed.