bluuebunny/crossref_metadata_2025_split huggingface dataset:
Insights into the anatectic origin of granites parental to tungsten mineralization: A case study from the trans‐Aravalli terrane, NW India
Authors: Roy Jitendra Kumar , Naik Aditya , Bhattacharya Sourabh 
Published: February 2024

AbstractPotential progenitors for W (±Sn) deposits include peraluminous granites of S‐type affinity. The anatectic origin of such granites parental to W mineralization has received little attention. This study focuses on Balda Granite (BG), a peraluminous intrusion parental to W‐rich ore bodies in the Sirohi region (NW India). We reflect upon the potential source for BG and investigate its anatectic origin through open‐system phase equilibria modeling. On the prograde path, muscovite‐ and biotite‐dehydration reactions at 675–745°C and 755–870°C yield ~10 and 13 wt.% melt, respectively. Si, K, Al, and Fe contents of the cumulative melt increased with progressive anatexis. Modeling results suggest high‐T (>800°C) stability of the peritectic garnet, which is abundantly observed in the leucosome‐dominated migmatitic patches. Cumulative melt extracted till 868°C was chosen to model the crystal fractionation along three polybaric gradients of 30, 45, and 60°C/kbar. As the modeled anatectic melt cooled, its peraluminosity and maficity decreased progressively. With the intermediate cooling gradient of 45°C/kbar, the melt achieved complete crystallization at ~7 km, the depth at which the BG had been emplaced and evolved into a W‐rich residual (fractionated) model melt. In terms of peraluminosity, and major and trace element (Lu, Sc, Dy, Y, Yb) chemistry, the fractionated (residual) model melt compares well with BG. This study also models the W concentration in the anatectic melt during its generation and fractional crystallization. We argue for the origin of BG through high‐T anatexis of Sirohi Group metapelites and cooling (and fractional crystallization) of the parent anatectic melt at the maximum gradient of 45°C/kbar. Thus, a high‐T anatectic origin of granites parental to W deposits may be more prevalent than so far inferred.
Ulectomy in a patient with nephrotic syndrome under investigation for Galloway‐Mowat syndrome: a case report
Authors: Alves Gabriela Reis , Javaroni Julia Biliato , Moura Ana Paula Gomes e , Consolaro Alberto , Segato Raquel Assed Bezerra 
Published: February 2024

AbstractThe aim of this study is to report a case in which a patient with nephrotic syndrome underwent surgery to remove fibrous gum tissue (ulectomy). An 8‐year‐old patient, diagnosed with early onset nephrotic syndrome due to a mutation in the NUP107 gene, had received a kidney transplant and was therefore taking various medications, including immunosuppressants. On oral examination, the patient was found to have a fibrous gingiva that was preventing the eruption of the upper permanent central incisors. A ulectomy was performed and the gingival tissue was sent for histopathological analysis, which showed normal aspects. The upper right central incisor was seen in the oral cavity 15 days after surgery. A second procedure was carried out to facilitate the eruption of the upper left incisor, which was visualized in the oral cavity 30 days later. In addition, oral manifestations such as maxillary atresia, ogival palate and mouth breathing were observed. Therefore, the role of the dental surgeon in the lives of transplanted children is considered important, as they often take various medications that can affect their oral health. Thus, early diagnosis and effective treatment will be essential to prevent future malocclusions and thus improve the quality of life of these patients.
Mucocutaneous histoplasmosis as the first manifestation of AIDS
Authors: Medina Janaina B. , Monguilhott‐Falbo Francèle , Teixeira‐Leite Cristiane , Trierveiler Marilia , Braz‐Silva Paulo Henrique , Ortega Karem L. 
Published: February 2024

AbstractImmunosuppressed patients can present with opportunistic infections resulting from an intrinsic systemic disease, which easily evolves into more aggressive and less common conditions. This work reports a clinical case of a female patient with histoplasmosis lesions in the nasal and oral mucosa, including pulmonary, hematological, and hepatic impairment, which led to the diagnosis of HIV seropositivity. In the presence of severe immunosuppression, morbidity is increased due to deep fungal infections and their unusual clinical characteristics can make diagnosis difficult. Therefore, it can be very helpful to recognize these clinical characteristics in order to determine early diagnostic interventions. It is important to recognize mucocutaneous manifestations of histoplasmosis because the biopsy of these lesions, and subsequent histopathological analysis, is one of the quickest, safest, and cheapest methods of diagnosis.
Unidirectional and combined transitional flow bedforms: Controls on process and distribution in submarine slope settings
Authors: Taylor William J. , Hodgson David M. , Peakall Jeff , Kane Ian A. , Morris Emma A. , Flint Stephen S. 
Published: February 2024

ABSTRACTMixed grain‐size bedforms comprise alternating sand‐rich and poorly sorted mud‐rich laminae and bands. These bedforms have been identified in distal submarine settings formed underneath unidirectional flows. This study documents mixed grain‐size bedforms in a proximal submarine slope setting formed beneath both unidirectional and combined flows. Core and outcrop data with well‐constrained palaeogeographical context are used to describe two types of mixed grain‐size bedform. Type A bedforms comprise mud‐rich current ripples and low‐amplitude bed‐waves with alternating concave and planar sandstone–mudstone foresets that pass into mud‐rich troughs, and aggradational sinusoidal laminasets. Type B bedforms consist of sandstone–mudstone laminasets that comprise rounded, biconvex ripples with sigmoidal‐shaped foresets and swale and hummock‐like laminasets and banded sets. These bedforms occur in channel‐margin, internal‐levée and external‐levée, intraslope and disconnected lobe environments, and represent 27 to 63% by stratigraphic thickness of the studied successions. They are interpreted as deposits of clay‐rich transitional flows, whose depositional style is governed by the balance of cohesive and turbulent forces, and the rate of flow deceleration. Type B bedforms are further interpreted as combined transitional flow deposits, resulting from flow deflection and ponding processes by seabed topography. Upward and lateral transitions between different bedforms create distinct bedform sequences, demonstrating progressive spatio‐temporal transformations in flow properties and their topographic interactions. By using a well‐constrained palaeogeographical setting, mixed grain‐size bedforms are shown to be situated close to sites of erosion into muddy substrates, abrupt losses in confinement, and/or changes in slope gradient. These bedforms demonstrate that flow transformation and transitional flow behaviour are not restricted to distal submarine settings. Furthermore, mixed grain‐size bedforms are not a diagnostic criterion for bottom currents, because such flows cannot account for the high mud content in laminasets, or the interlamination of sand and mud.
Effects of organisational factors and employee characteristics on employers' reporting of client violence in non‐institutional social services in Sweden
Authors: Brodin Helene , Shanks Emelie 
Published: February 2024

AbstractSocial services in the welfare sector consist of women‐dominated jobs generally characterised by arduous working conditions, including exposure to client violence. Although there is a rather extensive research base on client violence in institutional social services, less is known about how client violence is handled in noninstitutional social services. Using longitudinal data obtained from the Swedish Work Environment Agency's register on work injuries caused by workplace violence, we examined the effects of organisational factors and employee characteristics on the reporting of client violence in noninstitutional social services. We found that most of the reports about work injuries caused by client violence are filed by public employers and that most reports concern occupational groups performing direct care services in clients' homes. Moreover, although most reports include female employees and incidents of physical violence, reports concerning male employees are comparatively more likely to include physical violence, and reports concerning female employees are comparatively more likely to include threats. Taken together, our findings point to a much‐needed improvement of health and safety measures for care workers in noninstitutional social services in Sweden.
In search of a job—But which one? How unemployed people revise their occupational expectations
Authors: Demazière Didier 
Published: February 2024

AbstractConducting a job search implies the identification of a target—an intended job. However, this assumption has been little studied, and just two main conclusions have been drawn, namely: jobseekers have an incentive to adjust their targets to the jobs available, and returning to work tends to lead to occupational downgrading. This article explores how job search experiences shape and alter targets. Biographical interviews were conducted with 57 unemployed people registered with the French public employment service. Ultimately, all of them revise their occupational expectations as, faced with the uncertainties inherent to the job search and experiencing difficulties in reaching their priority targets, they try to adapt and define more realistic goals. Four contrasting processes of expectation revision are used to track these tensions between desirability and realism. In conclusion, we stress the following facts: that unemployed people are flexible and develop rationales in order to adapt to the labour market; that their experience of failure, alongside advice and beliefs arising in the course of the job search feed directly into these revisions, and that these revisions both vary in magnitude and reflect inequalities in the defining process of target jobs.
Transcriptome analysis of frontal fibrosis alopecia revealed involvement of immune cells and ferroptosis
Authors: Liu Lin , Xue Yuzhou , Wang Jingyu , Shen Chengcheng , Li Yuhao , Huang Yujing 
Published: February 2024

AbstractBackgroundFrontal fibrosis alopecia (FFA) is a primary cicatricial alopecia and has received increasing attention in recent years. However, the pathogenesis of FFA has not been fully elucidated.Methods and resultsHerein, we collected the transcriptome data of scalp lesions of seven patients with FFA and seven healthy controls. The differential expression analysis and weighted gene co‐expression network analysis were conducted and we identified 458 differentially expressed genes (DEGs) in two key modules. Later, we performed functional enrichment analysis and functional modules identification, revealing the participation of immune response and fatty acid metabolism. Based on the results, we processed further studies. On the one hand, we analyzed the infiltrating immune cells of FFA through CIBERSORT algorithm, indicating the activation of M1 macrophage and CD8+ T cell. On the other hand, considering lipid metabolism of FFA and oxidative stress of hair follicle cells in alopecia, we explored the potential ferroptosis of FFA. By intersection of DEGs and ferroptosis‐related genes from FerrDb database, 19 genes were identified and their expression was validated in an external dataset containing 36 FFA cases and 12 controls. Then, we used LASSO algorithms to construct a four‐gene diagnostic model, which achieved an AUC of 0.924 in validation dataset. Additionally, the immune cells were found to be related to ferroptosis in FFA.ConclusionTaken together, this study contributed to reveal the molecular mechanisms of FFA and is expected to inspire future research on treatment.
Nudix hydrolase WvNUDX24 is involved in borneol biosynthesis in Wurfbainia villosa
Authors: Yang Peng , Chen Yuan‐Xia , Wang Tian‐Tian , Huang Xue‐Shuang , Zhan Ruo‐Ting , Yang Jin‐Fen , Ma Dong‐Ming 
Published: February 2024

SUMMARYBorneol, camphor, and bornyl acetate are highly promising monoterpenoids widely used in medicine, flavor, food, and chemical applications. Bornyl diphosphate (BPP) serves as a common precursor for the biosynthesis of these monoterpenoids. Although bornyl diphosphate synthase (BPPS) that catalyzes the cyclization of geranyl diphosphate (GPP) to BPP has been identified in multiple plants, the enzyme responsible for the hydrolysis of BPP to produce borneol has not been reported. Here, we conducted in vitro and in vivo functional characterization to identify the Nudix hydrolase WvNUDX24 from W. villosa, which specifically catalyzes the hydrolysis of BPP to generate bornyl phosphate (BP), and then BP forms borneol under the action of phosphatase. Subcellular localization experiments indicated that the hydrolysis of BPP likely occurs in the cytoplasm. Furthermore, site‐directed mutagenesis experiments revealed that four critical residues (R84, S96, P98, and G99) for the hydrolysis activity of WvNUDX24. Additionally, the functional identification of phosphatidic acid phosphatase (PAP) demonstrated that WvPAP5 and WvPAP10 were able to hydrolyze geranylgeranyl diphosphate (GGPP) and farnesyl diphosphate (FPP) to generate geranylgeranyl phosphate (GGP) and farnesyl phosphate (FP), respectively, but could not hydrolyze BPP, GPP, and neryl diphosphate (NPP) to produce corresponding monophosphate products. These findings highlight the essential role of WvNUDX24 in the first step of BPP hydrolysis to produce borneol and provide genetic elements for the production of BPP‐related terpenoids through plant metabolic engineering and synthetic biology.
Adipocytes in synovial fluid cytology: An approach for diagnosing synovial lipomatosis
Authors: Agulla Beatriz , Vizcaíno Nùria , Velarde Roser , Estruch Josep , Domínguez Elisabet , Pastor Josep 
Published: February 2024

AbstractA 2‐year‐old neutered male bullmastiff dog was presented with chronic left hind limb lameness. Physical examination revealed left stifle effusion and medial buttress without cranial tibial thrust. Radiographs showed joint effusion and new bone formation at the patella apex. Magnetic resonance imaging showed increased synovial fluid, widening of the joint space, abnormal infrapatellar fat body and thinning of the cranial cruciate ligament. Synoviocentesis and cytologic evaluation of synovial fluid revealed marked mononuclear inflammation with abundant fatty tissue, suggesting synovial lipomatosis in conjunction with the imaging findings. The disease was confirmed histologically after sampling the lesion during arthrotomy. Synovial lipomatosis, characterized by extensive synovial adipose tissue proliferation of the synovial membrane, is a rare “tumor‐like” disorder that usually affects the stifle. Although the etiology remains unclear, joint trauma, inflammation, instability, and lipid abnormalities have been proposed as causes. Inflammatory factors may promote synoviocyte and adipocyte hyperplasia that perpetuate the process. Surgical removal may be suggested to eliminate triggers and prevent future recurrences. The report provides the first cytological description of adipocytes in synovial fluid associated with the diagnosis of synovial lipomatosis in dogs. This case report underscores the potential effectiveness of cytologic analysis of synovial fluid smears, in combination with magnetic resonance imaging (MRI), for diagnosing this condition and reducing complications associated with arthrotomy for sampling purposes. Additionally, the case highlights that synovial lipomatosis should be considered as a potential differential diagnosis for synovial masses in dogs. Further cases are needed to validate these observations in veterinary medicine.
Nonautonomous double‐phase equations with strong singularity and concave perturbation
Authors: Papageorgiou Nikolaos S. , Rădulescu Vicenţiu D. , Yuan Shuai 
Published: February 2024

AbstractWe consider a nonlinear Dirichlet problem driven by a nonautonomous double‐phase differential operator and with a reaction consisting of a “strongly” singular term plus a concave perturbation. Using the Nehari method, we show the existence of a bounded strictly positive solution.
Blockage of aquaporin‐3 peroxiporin activity by organogold compounds affects melanoma cell adhesion, proliferation and migration
Authors: da Silva Inês V. , Pimpão Catarina , Paccetti‐Alves Inês , Thomas Sophie R. , Barateiro Andreia , Casini Angela , Soveral Graça 
Published: February 2024

AbstractAquaporin‐3 (AQP3) is a membrane channel with dual aquaglyceroporin/peroxiporin activity, facilitating the diffusion of water, glycerol and H2O2 across cell membranes. AQP3 shows aberrant expression in melanoma and its role in cell adhesion, migration and proliferation is well described. Gold compounds were shown to modulate AQP3 activity with reduced associated toxicity, making them promising molecules for cancer therapy. In this study, we validated the phenotype resulting from AQP3‐silencing of two melanoma cell lines, MNT‐1 and A375, which resulted in decreased H2O2 permeability. Subsequently, the AQP3 inhibitory effect of a new series of organogold compounds derived from Auphen, a potent AQP3 inhibitor, was first evaluated in red blood cells (RBCs) that highly express AQP3, and then in HEK‐293T cells with AQP3 overexpression to ascertain the compounds’ specificity. The first screening in RBCs unveiled two organogold compounds as promising blockers of AQP3 permeability. Moderate reduction of glycerol permeability but drastic inhibition of H2O2 permeability was detected for some of the gold derivatives in both AQP3‐overexpressing cells and human melanoma cell lines. Additionally, all compounds were effective in impairing cell adhesion, proliferation and migration, although in a cell type‐dependent manner. In conclusion, our data show that AQP3 peroxiporin activity is crucial for melanoma progression and highlight organogold compounds as promising AQP3 inhibitors with implications in melanoma cell adhesion, proliferation and migration, unveiling their potential as anticancer drugs against AQP3‐overexpressing tumours.
imageKey points
AQP3 affects cellular redox balance.
Gold compounds inhibit AQP3 permeability in melanoma cells.
AQP3 is involved in cell adhesion, proliferation and migration of melanoma.
Blockage of AQP3 peroxiporin activity impairs melanoma cell migration.
Gold compounds are potential anticancer drug leads for AQP3‐overexpressing cancers.
Exogenous Collagen Crosslinking is Highly Detrimental to Articular Cartilage Lubrication
Authors: Kupratis Meghan E. , Gonzalez Uriel , Rahman Atia , Burris David L. , Corbin Elise A. , Price Christopher 
Published: February 2024

Abstract
Healthy articular cartilage is a remarkable bearing material optimized for near-frictionless joint articulation. Because its limited self-repair capacity renders it susceptible to osteoarthritis (OA), approaches to reinforce or rebuild degenerative cartilage are of significant interest. While exogenous collagen crosslinking (CXL) treatments improve cartilage's mechanical properties and increase its resistance to enzymatic degradation, their effects on cartilage lubrication remain less clear. Here, we examined how the collagen crosslinking agents genipin (GP) and glutaraldehyde (GTA) impact cartilage lubrication using the convergent stationary contact area (cSCA) configuration. Unlike classical configurations, the cSCA sustains biofidelic kinetic friction coefficients (μk) via superposition of interstitial and hydrodynamic pressurization (i.e., tribological rehydration). As expected, glutaraldehyde- and genipin-mediated CXL increased cartilage's tensile and compressive moduli. Although net tribological rehydration was retained after CXL, GP or GTA treatment drastically elevated μk. Both healthy and “OA-like” cartilage (generated via enzymatic digestion) sustained remarkably low μk in saline- (≤0.02) and synovial fluid-lubricated contacts (≤0.006). After CXL, μk increased up to 30-fold, reaching values associated with marked chondrocyte death in vitro. These results demonstrate that mechanical properties (i.e., stiffness) are necessary, but not sufficient, metrics of cartilage function. Furthermore, the marked impairment in lubrication suggests that CXL-mediated stiffening is ill-suited to cartilage preservation or joint resurfacing.
The Post-Buckling Behavior of a Beam Constrained by Nonlinear Springy Walls
Authors: Judah Nitzan , Givli Sefi 
Published: February 2024

Abstract
The post-buckling behavior of a beam that is subjected to lateral constraints is of relevance to a range of medical and engineering applications, such as endoscopic examination of internal organs, the insertion of a guidewire into an artery in-stent procedures, root growth, deep-drilling, and more. In this paper, we address a disconnect between the existing literature and the reality of these systems, in which the lateral constraints are flexible and experience nonlinear deformations. As a step towards bridging this gap, we consider a beam undergoing planar deformations that is laterally constrained by a nonlinear springy wall, i.e., a wall that is laterally pushed by the beam against a nonlinear spring. Based on a simplified mathematical model, we obtain closed-form analytical solutions, which provide valuable insights and intuition. For example, we show that important features of the behavior, such as the transition from point contact to line contact and switching to the next mode, are dictated solely by a non-dimensional force, regardless of all other parameters of the system, and that the full description of the behavior is possible by means of two non-dimensional quantities that describe the relative stiffness of the nonlinear spring compared to that of the beam. The results also highlight the fundamental differences between the behavior with a stiffening spring or with a softening spring, such as the number of attainable modes and the monotonicity of the overall force–displacement relation. These results are then validated by experiments.
Optimizing Engineered Products for Their Social Impacts on Multiple Stakeholders
Authors: Stevenson Phillip D. , Mattson Christopher A. , Salmon John L. , Hatch Nile W. 
Published: February 2024

Abstract
Engineered products are often optimized based on engineering requirements, user requirements, cost, and performance. This strategy is well suited for most applications, but products designed specifically to improve the lives of users and communities would benefit from an approach that helps engineers optimize a product based also on its social impacts. This paper introduces several optimization problem formulations adapted from multi-stakeholder strategies in the economics and business management literature. Each optimization problem formulation optimizes a product’s social impact according to the ideology and principles inherent to the adapted multi-stakeholder strategy. A case study is presented for a cassava peeling machine that is being developed for farmers in the Brazilian Amazon. Finally, the resulting peeler design configurations and social impacts are discussed to illustrate the advantages and disadvantages of each strategy.