bluuebunny/crossref_metadata_2025_split huggingface dataset:
Temperature‐controlled radiofrequency ablation for the treatment of chronic rhinitis: Two‐year outcomes from a prospective multicenter trial
Authors: Takashima Masayoshi , Stolovitzky J. Pablo , Ow Randall A. , Silvers Stacey L. , McDuffie Chad M. , Dean Marc , Sedaghat Ahmad R. , Tajudeen Bobby A. 
Published: January 2024

AbstractBackgroundMinimally invasive temperature‐controlled radiofrequency (TCRF) ablation of the posterior nasal nerve (PNN) demonstrated a significant larger treatment effect on the symptom burden of chronic rhinitis patients than a sham control (no energy delivery) at the 3‐month primary endpoint of this trial.MethodsTwo‐year posttreatment outcomes for patients treated in a prospective, multicenter, patient‐blinded randomized controlled trial were determined by combining the index active treatment‐arm and index control‐arm crossover patients into a single group (after the primary endpoint) to evaluate the treatment effect durability and long‐term effects on concomitant chronic rhinitis medication usage.ResultsThe mean baseline reflective total nasal symptom score (rTNSS) was 8.2 (95% confidence interval [CI], 7.9–8.6; N = 104). At 2 years (N = 79), the mean change in rTNSS was −5.3 (95% CI, −5.8 to −4.8; p < 0.001; 64.6% improvement). The 2‐year responder rate (≥30% improvement in rTNSS) was 87.3% (95% CI, 78.0–93.8). All four components of the rTNSS (rhinorrhea, congestion, sneezing, and nasal itching) showed significant improvement over baseline, with rhinorrhea and congestion showing the most improvement. Postnasal drip and cough symptoms were also significantly improved. At 2 years, 81.0% (95% CI, 70.6–89.0) reported a minimal clinically important difference of ≥0.4‐point improvement in the mini‐rhinoconjunctivitis quality of life questionnaire score. Of 56 patients using chronic rhinitis medications at baseline, 25 of 56 (44.6%) either stopped all medication use (7/56 [12.5%]) or stopped/decreased (18/56 [32.1%]) use of ≥1 medication class at 2 years. No serious adverse events related to the device/procedure were reported over 2 years.To determine the potential effect of patients who left the trial over 2 years on the responder rate, the responder statuses of the 14 patients with follow‐up data who were lost to follow‐up/withdrew/died were imputed by the last observation carried forward and the responder statuses of all nine patients who had an additional nasal procedure were imputed to nonresponder, resulting in a 2‐year responder rate of 79.4% (95% CI, 70.3–86.8).ConclusionTCRF ablation of the PNN is safe and resulted in a significant and sustained reduction in chronic rhinitis symptom burden through 2 years and a substantial reduction in concomitant medication burden.
Large‐Scale Continuous and In Situ Photosynthesis of Hydrogen Peroxide by Sulfur‐Functionalized Polymer Catalyst for Water Treatment
Authors: Chu Chengcheng , Chen Zhong , Yao Ducheng , Liu Xinru , Cai Mingjie , Mao Shun 
Published: January 2024

AbstractPhotocatalytic H2O2 generation system based on polymer catalyst receives increasing attention in recent years; however, the insufficient charge separation efficiency and low oxygen adsorption/activation capacity severely limit their potential application. In this study, a sulfur (C=S) functionalized polymer catalyst is reported through a green water‐mediated and catalyst‐free multi‐component reactions (MCRs) route. The sulfur functional group endows the polymer with a suitable energy band and facilitates the separation of photogenerated electron‐hole pair. The reported polymer achieves a high H2O2 production efficiency (3132 μmol g−1 h−1) in pure water without oxygen aeration. To demonstrate their potential in in situ wastewater treatment, a panel reactor system (20×20 cm) is constructed for large‐scale production of H2O2, which realizes continuous degradation of emerging pollutants including antibiotics and bisphenol A under natural sunlight irradiation condition. The H2O2 utilization efficiency of the photo‐self‐Fenton system using in situ generated H2O2 is found 7.9 times higher than that of the traditional photo‐Fenton system. This study offers new insights in green synthesis and design of functional polymer photocatalyst, and demonstrates the feasibility of panel reactor system for large‐scale continuous H2O2 photocatalytic production and water treatment.
Identification of Direct Anchoring Sites for Monoatomic Dispersion of Precious Metals (Pt, Pd, Ag) on CeO2 Support
Authors: Wang Fei , Li Kai , Li Bolang , Wang Chunxue , Li Zhao , Zhang Yan , Shan Wenpo , Yu Yunbo , Zhang Changbin , Fu Qiang , Ning Ping , Francisco Joseph S. , Zeng Xiao Cheng , He Hong 
Published: January 2024

AbstractMonoatomic dispersion of precious metals on the surface of CeO2 nanocrystals is a highly practical approach for dramatically reducing the usage of precious metals while exploiting the unique properties of single‐atom catalysts. However, the specific atomic sites for anchoring precious metal atoms on the CeO2 support and underlying chemical mechanism remain partially unknown. Herein, we show that the terminal hydroxyls on the (100) surface are the most stable sites for anchoring Ag atoms on CeO2, indicating that CeO2 nanocubes are the most efficient substrates to achieve monoatomic dispersion of Ag. Importantly, the newly identified chemical mechanism for single‐metal‐atom dispersion on CeO2 nanocubes appears to be generic and can thus be extended to other precious metals (Pt and Pd). In fact, our experiments also show that atomically dispersed Pt/Pd species exhibit morphology‐ and temperature‐dependent CO selectivity in the catalytic CO2 hydrogenation reaction.
Acid‐Base Cascades in Zeotype Single Crystal for Sugar Conversion
Authors: Sun Pengyao , Wang Haiyong , Wang He , Ling Wenmeng , Liu Yong , Zhou Wenguang , Liao Yuhe , Wang Liang , Lin Yue , Wang Chenguang 
Published: January 2024

AbstractThe chemically catalyzed production of fructose syrup from high concentrations of glucose is crucial for the food industry and biorefining. In this work, a single crystal catalyst was synthesized via protective desilication of zeolite while incorporating indium. Glucose was isomerized in methanol at concentrations as high as 33 wt % before being hydrolyzed with water. The final fructose production was 54.9 %, with 89.1 % selectivity and 93.3 % sugar recovery, the highest isomerization rate at the highest concentration ever reported. Indium was present in the single‐crystal catalyst as oxide nanoparticles and boundary framework atoms, and it achieved intelligent cooperation in the production of fructose syrup in methanol by catalyzing isomerization and selective glycosidation, minimizing degradation due to fructose accumulation and eliminating side reactions. This study contributed to the advancement of the industrial practice of chemically catalyzed glucose isomerization.
Inscribing a new page in the history of Ukrainian psychoanalysis during the wartime: The call for contributions
Authors: Velykodna Mariana , Butsykin Yehor , Dorozhkin Valeriy , Lupis Alexander , Melnychuk Tetiana , Nalyvaiko Natalia , Pavlovska Olga , Pustovoyt Mykhaylo , Tkalych Marianna , Yakushko Oksana 
Published: January 2024

AbstractThis correspondence introduces several distinct current efforts by Ukrainian psychoanalytic practitioners and researchers from various clinical, scholarly, and applied fields to support the sustainable development of psychoanalytic training and work in the context of the ongoing 2022 Russian invasion of Ukraine. Among these developments are (a) the translation of the classic and contemporary psychoanalytic texts into the Ukrainian language, (b) the promotion of Ukrainian psychoanalytic contributions within Ukraine and abroad, and (c) the support of psychoanalysis and psychoanalytic psychotherapy as an evidence‐based practice to be officially recognized in Ukraine. The initiatives were integrated with the launch of a scholarly peer‐reviewed online open‐access journal—the Ukrainian Psychoanalytic Journal—which has been confirmed by the Ukrainian Ministry of Education and Science as a scientific periodical. In addition to describing these initiatives, this contribution serves as an invitation to international psychoanalytic audiences to contribute to these processes, including via workshops on psychoanalytic writing and publication, joint panel discussions, or collaborative research projects with Ukrainian psychoanalytic professionals. We also welcome submissions of original previously published (with copyright permission) or unpublished papers to be translated and published in the Ukrainian language.
Circular e‐waste ecosystems in necessity‐driven contexts: The impact of formal institutional voids
Authors: Derks Milou , Bidmon Christina , Ciulli Francesca 
Published: January 2024

AbstractRecent studies suggest an ecosystem view is most appropriate for understanding the impact of institutional voids on entrepreneurial activities. Expanding the focus to the entrepreneurial ecosystem is crucial for tackling complex low‐ and middle‐income countries' (LMICs) environmental challenges, as the transition to circular e‐waste management, which are heavily impacted by the institutional environment. Moreover, most entrepreneurs in LMICs engage in circular practices out of economic necessity, rather than environmental reasons. However, scholars have overlooked the effects of institutional voids on entrepreneurial ecosystems' potential to grow and realize environmental benefits. This study investigates how formal institutional voids impact the evolution of circular ecosystems in necessity‐driven contexts in LMICs. We study the evolution of a circular e‐waste ecosystem in Kenya and uncover two key phases: emergence and growth. We show that formal institutional voids' impact differs across phases; regulatory and contract enforcement voids create opportunities for informal and private actors to establish e‐waste collection, repair, remanufacture, and recycle businesses, thereby facilitating the emergence of the circular ecosystem. However, labor market, capital market, product market, regulatory, and contract enforcement voids hamper its growth. Specifically, the lack of skills, equipment, guidelines, and financial incentives hinders advanced repairs and remanufactures and limits recycling opportunities, while the lack of formal e‐waste infrastructure increases illegal dumping and negatively impacts human health and the environment. We develop propositions and a phase model to explain the impact of formal institutional voids on the evolution of circular e‐waste ecosystems and the realization of environmental benefits in necessity‐driven contexts.
High‐Risk Behaviours, Suicide and Social Isolation in Street Adolescents in Iran: A Cross‐Sectional Descriptive Study
Authors: Ghelbash Zakiye , Ghasemloo Hamed , Ghelbash Tahereh , Sharifi Ehsan 
Published: January 2024

AbstractStreet adolescents are exposed to many high‐risk behaviours such as drug abuse, risky sexual activity, violence and suicide. This issue is a challenge and concern in the health field in developing societies due to the lack of adequate welfare and support facilities. This study aimed to investigate high‐risk behaviours among street adolescents and the factors involved. This study was a cross‐sectional study of 124 street adolescents in Shiraz. Data were collected through four questionnaires: demographic information, Beck Scale for Suicidal Ideation (BSSI), Iranian Adolescents Risk Scale (IARS) and Russell Social Isolation Scale in the form of interviews. The highest mean risky behaviour in these participants was 17.07 ± 3.31 for sexual intercourse. The lowest risky behaviour observed in adolescents was high‐risk driving, averaging 8.21 ± 2.59. According to the results, 31.5 per cent showed a high risk of suicidal ideation. Also, 68.5 per cent of these adolescents reported a tendency to severe isolation. In general, street adolescents in Iran are highly vulnerable to high‐risk behaviours. This group of adolescents needs comprehensive support programmes from education centres, the Welfare Department and the Ministry of Health.
Covid‐19‐related right hip monoarthritis: A case report and literature review
Authors: Ismael Ayouba Tinni , Yves‐Zakari Kossi Odjo Dogbe , Tchenadoyo Bayala Yannick Laurent , Mamadou Boulama Malam Boulama , Nadège Yameogo Wendyam , Aziz Abdoul , Rachidou Aboubacar , Fanata Moussa 
Published: January 2024

Key Clinical MessageThis article presents the case of a young patient with severe acute left hip pain who tested positive for COVID‐19. The diagnostic approach and management are presented, followed by a review of the literature. This 11‐year‐old student was admitted for acute left hip pain of abrupt onset, inflammatory, evolving for 24 h in a febrile context with no change in general condition. The initial workup revealed a hyperleukocytosis in the blood count, CRP 198.52 mg/L, and a 95 mm SV. The pelvic X‐ray was unremarkable, and the hip ultrasound showed synovial hypertrophy, with no effusion on Doppler examination. The situation worsened 24 h later with the onset of acute respiratory distress syndrome. The chest X‐ray showed bilateral alveolar interstitial lung disease, and the CT scan showed hyperdensity and crazy paving. The COVID‐19 RDT test on a nasopharyngeal sample came back positive, as did the RT‐PCR. Death occurred a few hours later in acute respiratory distress. Our case is consistent with what has been reported in the literature, but requires further study on an international scale to better define the phenotype of the disease.
Sensitization profiles to house dust mite Dermatophagoides pteronyssinus molecular allergens in the Lithuanian population: Understanding allergic sensitization patterns
Authors: Biliute Gabija , Miskinyte Monika , Miskiniene Asta , Zinkeviciene Aukse , Kvedariene Violeta 
Published: January 2024

AbstractBackgroundHouse dust mite (HDM) allergy is a prevalent global health concern, with varying sensitization profiles observed across populations. We aimed to provide a comprehensive assessment of molecular allergen sensitization patterns in the Lithuanian population, with a focus on Dermatophagoides pteronyssinus (Der p), and investigate patterns of concomitant reactivity among different allergens to enhance the accuracy of HDM allergy diagnostics.MethodsA comprehensive analysis of 1520 patient test results in Lithuania from 2020 to 2022 was performed. Sensitization patterns to major (Der p 1, Der p 2, and Der p 23) and minor (Der p 5, Der p 7, and Der p 21) Der p allergen components were described using molecular‐based diagnostics. Additionally, we investigated sensitization to allergen components from other allergen sources, including tropomyosins (Der p 10, Per a 7, Pen m 1, Ani s 3, Blo t 10) and arginine kinases (Pen m 2, Bla g 9, Der p 20).ResultsThis study reveals a high prevalence of HDM sensitization in Lithuania ‐ 481 individuals (45.38% of the sensitized group) exhibited sensitization to at least one Der p allergen component. Importantly, within the sensitized group, 37.21% of patients were sensitized to Der p 5, Der p 7, or Der p 21 in addition to major allergenic components. Distinct sensitization patterns were observed across different age groups, indicating the influence of age‐related factors. Furthermore, we confirmed cross‐reactivity between Der p 5 and Blo t 5 as well as between Der p 21 and Blo t 21, emphasizing the clinical relevance of these associations. We also highlighted the complexity of sensitization patterns among tropomyosins and arginine kinases.ConclusionThis study provides valuable insights into HDM allergy sensitization profiles in Lithuania, emphasizing the importance of considering major and minor HDM allergen components for accurate diagnosis and management of HDM‐related allergic diseases. Differences between populations and age‐related factors impact sensitization patterns. Understanding concomitant reactivity among allergens, such as Der p 5 and Blo t 5, Der p 21 and Blo t 21, tropomyosins, and arginine kinases, is crucial for improving diagnostic strategies and developing targeted interventions for allergic individuals.
Single‐cell landscape of the cellular microenvironment in three different colonic polyp subtypes in children
Authors: Deng Yafei , Li Canlin , Huang Lanlan , Xiong Peiwen , Li Yana , Liu Yongjie , Li Songyang , Chen Weijian , Yin Qiang , Li Yong , Yang Qinglan , Peng Hongyan , Wu Shuting , Wang Xiangyu , Tong Qin , Ouyang Hongjuan , Hu Die , Liu Xinjia , Li Liping , You Jieyu , Sun Zhiyi , Lu Xiulan , Xiao Zhenghui , Deng Youcai , Zhao Hongmei 
Published: January 2024

AbstractBackgroundThe understanding of the heterogeneous cellular microenvironment of colonic polyps in paediatric patients with solitary juvenile polyps (SJPs), polyposis syndrome (PJS) and Peutz–Jeghers syndrome (PJS) remains limited.MethodsWe conducted single‐cell RNA sequencing and multiplexed immunohistochemistry (mIHC) analyses on both normal colonic tissue and different types of colonic polyps obtained from paediatric patients.ResultsWe identified both shared and disease‐specific cell subsets and expression patterns that played important roles in shaping the unique cellular microenvironments observed in each polyp subtype. As such, increased myeloid, endothelial and epithelial cells were the most prominent features of SJP, JPS and PJS polyps, respectively. Noticeably, memory B cells were increased, and a cluster of epithelial–mesenchymal transition (EMT)‐like colonocytes existed across all polyp subtypes. Abundant neutrophil infiltration was observed in SJP polyps, while CX3CR1hi CD8+ T cells and regulatory T cells (Tregs) were predominant in SJP and JPS polyps, while GZMAhi natural killer T cells were predominant in PJS polyps. Compared with normal colonic tissues, myeloid cells exhibited specific induction of genes involved in chemotaxis and interferon‐related pathways in SJP polyps, whereas fibroblasts in JPS polyps had upregulation of myofiber‐associated genes and epithelial cells in PJS polyps exhibited induction of a series of nutrient absorption‐related genes. In addition, the TNF‐α response was uniformly upregulated in most cell subsets across all polyp subtypes, while endothelial cells and fibroblasts separately showed upregulated cell adhesion and EMT signalling in SJP and JPS polyps. Cell–cell interaction network analysis showed markedly enhanced intercellular communication, such as TNF, VEGF, CXCL and collagen signalling networks, among most cell subsets in polyps, especially SJP and JPS polyps.ConclusionThese findings strengthen our understanding of the heterogeneous cellular microenvironment of polyp subtypes and identify potential therapeutic approaches to reduce the recurrence of polyps in children.
Gross primary production of Mediterranean watersheds: Using isotope mass balance approach to improve estimations
Authors: Mattei Alexandra , Huneau Frédéric , Garel Emilie , Santoni Sébastien , Leydier Thomas , Vystavna Yuliya 
Published: January 2024

AbstractGlobal‐scale estimates of carbon fluxes from satellite data‐driven models are constrained by considerable uncertainties regarding Gross Primary Production (GPP) and the lack of the watershed‐scale measurements required for model calibration. Recently conducted global modelling efforts indicate that semiarid ecosystems dominate the increasing trends and inter‐annual variation of net CO2 exchange with the atmosphere, but semi‐arid regions have received little attention with regard to GPP estimation. In this study, we used the distinct isotope effect of transpiration and evaporation to calculate transpiration losses and subsequently CO2 uptake by terrestrial vegetation through the water and carbon cycle using the water use efficiency of plants. By studying two Mediterranean watersheds with contrasted environmental conditions over several hydrological years, we found a strong dependence of GPP on annual and seasonal water availability. The results demonstrated that when compared to GPP values obtained in worldwide biomes using biological methods, our isotope approach was validated, highlighting the limitations of satellite‐data‐driven models like MODIS in capturing the impact of water stress on photosynthesis and GPP estimates. These results encourage investigation of GPP by the isotope mass balance approach where direct carbon flux measurements are rare or absent in order to help to substantiate, modify or shed doubt on interpolated GPP for those regions and achieve consensus on global GPP estimates. Given the relevant role of semi‐arid ecosystems in the global carbon balance as well as the limitation of existing data sets, our improved method based on the isotope mass balance approach helps to obtain rapid and affordable estimates of GPP for semi‐arid ecosystems.
Gender stereotypes may not influence the choice of female leaders: Experimental evidence from a crisis framed as social or economic during the COVID‐19 pandemic
Authors: Takizawa Ruri , Iacoviello Vincenzo , Ryan Michelle K. , Kulich Clara 
Published: January 2024

AbstractThis research examined whether female (vs. male) leaders are preferred during a pandemic when stereotypically feminine leadership is deemed useful. We hypothesized that citizens prefer female (vs. male) politicians when the crisis is framed as a social (vs. economic) crisis because they believe it requires feminine (vs. masculine) leadership. In a pilot study and three online experiments with US residents (Ntotal = 1675), we manipulated crisis type or a leadership candidate's gender for a task force. While participants indicated that a crisis framed as social (vs. economic) required more feminine leadership, they did not appoint a woman more or rated her as more suitable for the social crisis (vs. economic crisis or a no‐crisis situation). Furthermore, the female (vs. male) candidate was not perceived to possess more feminine leadership traits. Overall, participants did not rely on gender stereotypes when explicitly evaluating politicians. We discuss potential explanations for these unexpected results.
Determining role of structure in the stability increase of purple sweet potato anthocyanins bound to proteins
Authors: Zhang Zhiyi , Yu Qingqing , Zhao Shuang , Zhao Wenting , Wang Pan , Zhao Xiaoyan , Wang Dan 
Published: January 2024

AbstractThe stability of anthocyanins is poor, seriously affecting their biological activity. The effect of bovine serum albumin (BSA) on the stability of purple sweet potato anthocyanins (PSPA) and its mechanism of action was investigated. Eleven anthocyanins in purple sweet potato were identified, and the stability of PSPAs with different structures combined with BSA was analyzed separately. The results showed an interaction between BSA and PSPA by UV absorption and fluorescence spectra, in which PSPA could cause a fluorescence burst of BSA, and the binding of PSPA to BSA was in the form of 1:1. In addition, the interactions are spontaneous, and hydrophobic interactions dominate. The binding amount study showed that 1 mol/L of BSA binds 3 mol/L of PSPA. The results of zeta potential and particle size showed that the absolute value of the possibility was around 30 mV, and BSA could combine with PSPA to form nanoparticles with high stability. Molecular docking analysis showed that PSPA could be well embedded in the structural cavities of BSA. The binding sites were near sites I and II, hydrogen bonding and hydrophobic interactions act as the main drivers of binding. Finally, after binding, BSA could effectively improve the stability of PSPA, especially for different structures of PSPA. The binding of diacylated anthocyanins was more stable than monoacylated ones, peonidin was more stable than cyanidin, and caffeoyl was more stable compared to p‐hydroxybenzoyl and feruloyl.