bluuebunny/crossref_metadata_2025_split huggingface dataset:
CHALLENGES FACING YOUTH ENTERPRISE PERFORMANCE IN NYERI COUNTY
Authors: MBURU RACHEAL MUGURE 
Published: November 2023

The youth forms a large proportion of the Kenyan population. Though it is supposed to be the most productive, majority are unemployed. The main objective of the study was to establish the challenges facing youth enterprises in Nyeri County. The specific objectives were: to establish the effect of inaccessibility of capital on the performance of youth enterprises and to establish the effect of lack of entrepreneurial knowledge and skills on the performance of youth enterprises in Nyeri County. The study adopted simple random sampling to select 35 respondents. Descriptive research design was adopted and primary data was collected using structure questionnaires. Data collected was coded using a predetermined coding scheme and analyzed both qualitatively and quantitatively. Microsoft Office Excel was used. Quantitative analysis was done using descriptive statistics i.e. frequency counts, percentages, tables and graphs to describe distributions, per-charts to show differences in frequencies and bar charts to display nominal or ordinal data. The data was presented using pie charts, graphs, and tables as was found appropriate for each set of data. The study findings indicated that capital inaccessibility and lack of entrepreneurial knowledge and skills are obstacles towards the performance of youth enterprises. The study recommended for cheaper loans and entrepreneurial training of the youth before engaging in entrepreneurial activities.
Key Words: Youth, Youth Enterprises, Capital, Entrepreneurial Knowledge and Skills, Training
Les rythmes du silence
Authors: Chouinard Marie 
Published: November 2023

Dans ce texte très personnel, Marie Chouinard parle de son travail, depuis ses débuts, avec la voix, le souffle, le son, et, surtout, avec et par le silence. Puis, elle évoque son oeuvre chorégraphique «M», créée le 26 janvier 2023 au Grand Théâtre de Québec, particulièrement du point de vue de sa relation au son et à la musique. Elle témoigne également de sa collaboration avec le compositeur Louis Dufort, avec qui elle travaille depuis 25 ans, et du rôle particulier qu’il a joué dans «M», qui intègre une « partition vocale » de la chorégraphe.
Evaluation of the DNA Fragmentation of the Normozoosperms at the Pasteur Institute of Cote D’ivoire
Authors: N’Guessan Marie Florence , Kouadio Maxime , Beourou Sylvain , Méité Souleymane , Ekissi N’Gbésso Amos , Coulibaly Founzegue , Djaman Allico Joseph , Dosso Mireille 
Published: November 2023

Sperm DNA fragmentation appears to be an important indicator of male fertility and an important parameter for evaluating the positive prognosis of a pregnancy. The objective of our study was to determine the prevalence of DNA fragmentation of normozoosperms received at the Institut Pasteur of Cote d’Ivoire (IPCI).
For this we determined the DNA Fragmentation Index (DFI) of spermatozoa as well as its impact in normozoosperms. The spermogram was carried out according to the criteria of the World Health Organization (WHO) and the integrity of the sperm DNA was verified by the acridine orange test.
Of the 18 normozoosperms samples selected, an average of 20.28 ± 11.22% for the DNA fragmentation index was obtained. About 27.78% of the samples presented a high level of DFI which reflects a poor pregnancy prognosis. Thus, 27.78% of normozoosperms men have abnormal DNA which does not allow these individuals to be able to conceive. This study showed that DNA fragmentation is an important factor in sperm quality.
GIS-Based Analytical Hierarchy Process Modeling for Flood Vulnerability Assessment of Communities Along Otamiri River Basin Imo State, Nigeria
Authors: Uwandu I. G.  , Ejikeme J. O.  , Chukwu F. N.  
Published: November 2023

In recent times, communities along the Otamiri River Basin in Imo State have been grappling with flooding issues, especially during the rainy season. This occurs despite the presence of underground drainage systems. The primary concern is heavy rainfall causing the river to overflow and lead to flooding. Hence the study aimed at identifying the flood-prone areas in the Otamiri River Basin in Owerri, Imo State. The objectives are to establish factors for evaluating flood vulnerability within the study area; to classify and standardize the factors according to levels of vulnerability; to determine the reliability of the classified factors; and to produce a flood vulnerability map showing vulnerable areas in the study area. The methodology involved collecting Shuttle Radar Topography Mission and Sentinel 2A imagery of July 2022, and processing the data with ArcGIS and QGIS software to determine the topography and vulnerability areas through geo-referencing and classification. The Analytical Hierarchy Process (AHP) model was employed to identify high flood risk areas, considering factors like drainage density, slope, soil type, precipitation, population density, Euclidean distance, and land use. The study's results categorized vulnerability into five levels: Very Low (0.09% of Owerri, minimal risk), Low (12.93% with lower risk), Moderate (68.83% facing substantial risk), High (18.18% with significant risk), and Very High (0.03% posing extreme risk). These findings are recommended as foundational data for future flood studies in the region.
A VIOLÊNCIA CONTRA AS MULHERES DURANTE A PANDEMIA DE COVID 19 EM PORTUGAL
Authors: Cerejo Dalila , Rosa Rosário , Teixeira Ana Lúcia , Pasinato Wânia , Lisboa Manuel 
Published: November 2023

O contexto pandémico, particularmente o primeiro confinamento de 18 de março de 2020, trouxe uma enorme incerteza, tanto em Portugal como em todo o mundo, sobre o que estaria a acontecer às mulheres relativamente à sua exposição a situações de violência. Este artigo apresenta os principais dados obtidos no projeto O impacto da COVID-19 na violência contra as mulheres, desenvolvido em 2020. Através de uma amostra estatisticamente representativa de 1500 mulheres portuguesas (Continente e Regiões Autónomas) foi possível concluir que, durante o período do primeiro confinamento, as mulheres ficaram ainda mais expostas à violência do que anteriormente.
High Mechanical Strength Alloy‐like Minerals Prepared by Inorganic Ionic Co‐cross‐linking
Authors: Ma Zaiqiang , Kong Kangren , Yin Yu , Guo Zhengxi , Ma Xiaoming , Lin Qingyun , Wang Jie , Shen Yinlin , Lu Xingyu , Xu Xurong , Kong Xueqian , Liu Zhaoming , Tang Ruikang 
Published: November 2023

AbstractAlloys often combine different metals to generate superior mechanical properties. However, it is challenging to prepare high mechanical strength minerals with similar strategies. Using calcium carbonate (CaC) and calcium phosphate (CaP) as examples, this work synthesizes a group of compounds with the chemical formulas Ca(CO3)x(PO4)2(1‐x)/3 (0 < x < 1, CaCPs) by cross‐linking ionic oligomers. Unlike mixtures, these CaCPs exhibit a single temperature for the phase transition from amorphous to crystallized CaC (calcite) and CaP (hydroxyapatite). By heat‐induced synchronous crystallization, dual‐phase CaC/CaP with continuous crystallized boundaries are resembled to alloy‐like minerals (ALMs). The mechanical properties of the ALMs are adjusted by tailoring their chemical compositions to reach a hardness of 5.6 GPa, which exceed those of control calcite and hydroxyapatite samples by 430% and 260%, respectively. This strategy expands the chemical scope of inorganic materials and holds promise for preparing high‐performance minerals.
Multifunctional Chiral Five‐Coordinated Manganese(II) Complexes for White LED and X‐Ray Imaging Applications
Authors: Zhou Zijian , Jiang Tianxaing , Yang Yafeng , Deng Yongjing , Wang Mengzhu , Ma Yun , Liu Shujuan , Zhao Qiang 
Published: November 2023

AbstractIn this study, a pair of chiral manganese(II) complexes is reported based on phosphine oxide, denoted as R/S‐[(L)2MnBr]Br (L = 5,5′‐bis(diphenylphosphine oxide)−4,4′‐bi‐1,3‐benzodioxole). These complexes exhibit distinctive five‐coordinated crystal structures and high stability. In addition, R/S‐[(L)2MnBr]Br display intense red luminescence at room temperature and demonstrate outstanding circularly polarized luminescence property, featuring luminescence dissymmetry factor values of +1.56 × 10−2 and −1.94 × 10−2, respectively. By integrating S‐[(L)2MnBr]Br with commercial phosphors, a white light‐emitting diode is successfully fabricated with a correlated color temperature of 4512 K, achieving a remarkable color rendering index of 96.9. Furthermore, a exceptional scintillation performance is observed in the target compounds and ultimately showcase X‐ray imaging with a spatial resolution of up to 11.9 lp mm−1. This endeavor imparts invaluable insights for the advancement of prospective multifunctional chiral manganese(II)‐based luminescent materials.
A Giant Tunable Piezoelectric Performance in Two‐dimensional In2Se3 via Interface Engineering
Authors: Yuan Shuoguo , Zhang Yiming , Dai Minzhi , Chen Yancong , Yu Haiyan , Ma Zengsheng , Io Weng Fu , Luo Xin , Hou Pengfei , Hao Jianhua 
Published: November 2023

AbstractTwo‐dimensional (2D) layered piezoelectric materials have attracted enormous interest, which leads to wide applications in stretchable electronic, energy and biomedicine. The piezoelectric properties of 2D materials are mainly modulated by strain, thickness, defect engineering and stacked structure. However, the tunability of piezoelectric properties is typically limited by the small variation within one order of magnitude. It is challenging to obtain high tunable piezoelectric properties of 2D materials. Here, this study reports that the out‐of‐plane piezoelectric properties of 2D van der Waals In2Se3 are significantly manipulated using interface engineering. The variation value of piezoelectric properties is above two orders of magnitude, giving rise to the highest variation value in the 2D piezoelectric materials system. In particular, the 2D materials In2Se3 can be directly fabricated onto silicon substrate, which suggests its compatibility with the state‐of‐the‐art silicon semiconductor technology. Combining the experimental and computational results, this study reveals that the ultrahigh tunable piezoelectric properties result from the interface charge transfer effect. The work opens the door to design and modulate the unprecedented applications of atomic‐scale smart and multifunctional devices.
Designing high‐performance nonfused ring electron acceptors via side‐chain engineering
Authors: Zheng Xinming , Liu Wenlong , Wei Nan , Zhang Andong , Ran Guangliu , Shan Hongtao , Huo Hong , Liu Yahui , Lu Hao , Xu Xinjun , Tang Zheng , Zhang Wenkai , Bo Zhishan 
Published: November 2023

AbstractThe side‐chain has a significant influence on the optical properties and aggregation behaviors of the organic small molecule acceptors, which becomes an important strategy to optimize the photovoltaic performance of organic solar cells. In this work, we designed and synthesized three brand‐new nonfused ring electron acceptors (NFREAs) OC4‐4Cl‐Ph, OC4‐4Cl‐Th, and OC4‐4Cl‐C8 with hexylbenzene, hexylthiophene, and octyl side chains on the π‐bridge units. Compared with OC4‐4Cl‐Ph and OC4‐4Cl‐Th, OC4‐4Cl‐C8 with linear alkyl side chain has more red‐shift absorption, which is conducive to obtaining higher short‐circuit current density. Additionally, the OC4‐4Cl‐C8 film exhibits a longer exciton diffusion distance, and the D18:OC4‐4Cl‐C8 blend film displays faster hole transfer, weaker bimolecular recombination, and more efficient exciton transport. Furthermore, The D18:OC4‐4Cl‐C8 blend films may effectively form interpenetrating networks that resemble nanofibrils, which can facilitate exciton dissociation and charge transport. Finally, OC4‐4Cl‐C8‐based devices can be created a marvellously power conversion efficiency (PCE) of 16.56%, which is much higher than OC4‐4Cl‐Ph (12.29%)‐ and OC4‐4Cl‐Th‐based (11.00%) ones, being the highest PCE among the NFREA based binary devices. All in all, we have validated that side‐chain engineering is an efficient way to achieve high‐performance NFREAs.
Fluorination Strategy Towards Symmetry Breaking of Boron‐centered Tetrahedron for Poly‐fluorinated Optical Crystals
Authors: Qiu Haotian , Li Fuming , Jin Congcong , Yang Zhihua , Li Junjie , Pan Shilie , Mutailipu Miriding 
Published: November 2023

AbstractBorate crystals can be chemically and functionally modified by the fluorination strategy, which encourages the identification of emerging fluorooxoborates with a structure and set of characteristics not seen in any other oxide parents. However, the bulk of fluorooxoborates have been found accidentally, rational methods of synthesis are required, particularly for the infrequently occurring poly‐fluorinated components. Herein, we reported the use of bifluoride salts as a potent source of fluorine to prepare fluorooxoborates that contain rarely tri‐fluorinated [BF3X] (X=O and CH3) tetrahedra and eleven compounds were found. We identified the optical properties of the organofluorinated group [CH3BF3] and their potential for nonlinear optics for the first time. Among these, two non‐centrosymmetric components hold potential for the production of 266 nm harmonic coherent light for nonlinear optics, and more crucially, have the benefit of growing large size single crystals. Our study establishes experimental conditions for the coexistence of the diverse functional groups, enabling the production of poly‐fluorinated optical crystals.
A pattern of peri‐implantitis affecting middle implants in 3‐implant splinted prostheses
Authors: Prete Braedan RJ , Silva Michael AJ , Wong Brian C. , Deporter Douglas A. 
Published: November 2023

AbstractBackgroundPrevious investigators have noted an increased risk of crestal bone loss and failure of the middle implant of 3‐implant‐splinted (3‐IS) fixed dental prostheses (FDPs). Possible causes have included ill‐fitting prostheses, unhygienic prosthetic contours, and discrepancies in prosthetic platform heights.Methods & ResultsWe identified four cases in which the middle implant of a 3‐IS multiunit FDP suffered advanced bone loss, ultimately leading to implant removal. While more than one possible risk for implant failure existed in each case, a common thread was that the prosthetic platform of the middle implant for all patients was coronally positioned relative to the corresponding mesial and/or distal implants.ConclusionsSplinting three adjacent implants into one prosthesis may add risk for a variety of reasons possibly including small differences in the heights of the three prosthetic tables.Key pointsWhy are these cases new information?

Our observations suggest that discrepancies between implant prosthetic platforms supporting 3‐implant splinted, multiunit FDPs may be an added risk factor for middle implant failure.
What are the keys to successful management of these cases?

It is possible that small differences in apico‐coronal implant positioning with 3‐implant splinted multiunit FDPs may affect the success of the middle implants.
What are the primary limitations to success in these cases?

There is limited literature involving precise protocols and long‐term outcomes of 3‐implant splinted implant restorations.
Studies comparing 3‐implant splinted FDPs to other configurations are needed.
C9orf142 transcriptionally activates MTBP to drive progression and resistance to CDK4/6 inhibitor in triple‐negative breast cancer
Authors: Liao Li , Deng Ling , Zhang Yin‐Ling , Yang Shao‐Ying , Andriani Lisa , Hu Shu‐Yuan , Zhang Fang‐Lin , Shao Zhi‐Min , Li Da‐Qiang 
Published: November 2023

AbstractBackgroundTriple‐negative breast cancer (TNBC) presents the most challenging subtype of all breast cancers because of its aggressive clinical phenotypes and absence of viable therapy targets. In order to identify effective molecular targets for treating patients with TNBC, we conducted an integration analysis of our recently published TNBC dataset of quantitative proteomics and RNA‐Sequencing, and found the abnormal upregulation of chromosome 9 open reading frame 142 (C9orf142) in TNBC. However, the functional roles of C9orf142 in TNBC are unclear.MethodsIn vitro and in vivo functional experiments were performed to assess potential roles of C9orf142 in TNBC. Immunoblotting, real‐time quantitative polymerase chain reaction (RT‐qPCR), and immunofluorescent staining were used to investigate the expression levels of C9orf142 and its downstream molecules. The molecular mechanisms underlying C9orf142‐regulated mouse double minute 2 (MDM2)‐binding protein (MTBP) were determined by chromatin immunoprecipitation (ChIP) and dual‐luciferase reporter assays.ResultsIn TNBC tissues and metastatic lymph nodes, we observed that C9orf142 exhibited abnormal up‐regulation, and its elevated expression was indicative of unfavorable prognosis for TNBC patients. Both in vitro and in vivo functional experiments demonstrated that C9orf142 accelerated TNBC growth and metastasis. Further mechanism exploration revealed that C9orf142 transcriptionally activated MTBP, thereby regulating its downstream MDM2/p53/p21 signaling axis and the transition of cell cycle from G1 to S phase. Functional rescue experiment demonstrated that knockdown of MTBP attenuated C9orf142‐mediated tumour growth and metastasis. Furthermore, depletion of C9orf142 remarkably increased the responsiveness of TNBC cells to CDK4/6 inhibitor abemaciclib.ConclusionsTogether, these findings unveil a previously unrecognized effect of C9orf142 in TNBC progression and responsiveness to CDK4/6 inhibitor, and emphasize C9orf142 as a promising intervention target for TNBC treatment.
Multi‐omics analyses reveal spatial heterogeneity in primary and metastatic oesophageal squamous cell carcinoma
Authors: Huang Haitao , Li Na , Liang Yingkuan , Li Rutao , Tong Xing , Xiao Jinyuan , Tang Hongzhen , Jiang Dong , Xie Kai , Fang Chen , Chen Shaomu , Li Guangbin , Wang Bin , Wang Jiaqian , Luo Haitao , Guo Lingchuan , Ma Haitao , Jiang Wei , Feng Yu 
Published: November 2023

AbstractBackgroundBiopsies obtained from primary oesophageal squamous cell carcinoma (ESCC) guide diagnosis and treatment. However, spatial intra‐tumoral heterogeneity (ITH) influences biopsy‐derived information and patient responsiveness to therapy. Here, we aimed to elucidate the spatial ITH of ESCC and matched lymph node metastasis (LNmet).MethodsPrimary tumour superficial (PTsup), deep (PTdeep) and LNmet subregions of patients with locally advanced resectable ESCC were evaluated using whole‐exome sequencing (WES), whole‐transcriptome sequencing and spatially resolved digital spatial profiling (DSP). To validate the findings, immunohistochemistry was conducted and a single‐cell transcriptomic dataset was analysed.ResultsWES revealed 15.72%, 5.02% and 32.00% unique mutations in PTsup, PTdeep and LNmet, respectively. Copy number alterations and phylogenetic trees showed spatial ITH among subregions both within and among patients. Driver mutations had a mixed intra‐tumoral clonal status among subregions. Transcriptome data showed distinct differentially expressed genes among subregions. LNmet exhibited elevated expression of immunomodulatory genes and enriched immune cells, particularly when compared with PTsup (all P < .05). DSP revealed orthogonal support of bulk transcriptome results, with differences in protein and immune cell abundance between subregions in a spatial context. The integrative analysis of multi‐omics data revealed complex heterogeneity in mRNA/protein levels and immune cell abundance within each subregion.ConclusionsThis study comprehensively characterised spatial ITH in ESCC, and the findings highlight the clinical significance of unbiased molecular classification based on multi‐omics data and their potential to improve the understanding and management of ESCC. The current practices for tissue sampling are insufficient for guiding precision medicine for ESCC, and routine profiling of PTdeep and/or LNmet should be systematically performed to obtain a more comprehensive understanding of ESCC and better inform treatment decisions.
Non‐Newtonian laminar pulsating heat and fluid flow in plane duct
Authors: Altunkaya Ayse Nur , Aydin Orhan , Avci Mete 
Published: November 2023

AbstractIn the present study, laminar pulsating power‐law momentum and heat transfer in a uniformly heated plane duct is studied analytically. Assuming that fully developed conditions exist both hydrodynamically and thermally, a perturbation series method is utilized to derive analytical solutions for the momentum and energy balance equations, and the amplitude is prescribed as the perturbation parameter. For varying values of the power‐law index (), representing pseudoplastic, Newtonian, and dilatant fluids, effects of dimensionless amplitude () and frequency () on periodic and period‐averaged friction factor and Nusselt number are obtained. The results obtained for Newtonian fluid are shown to be in good harmony with the corresponding findings in the open literature.
Testing and treatment‐by‐attitude in psychotherapy for pathological narcissism: A clinical illustration
Authors: Kealy David , Gazzillo Francesco 
Published: November 2023

AbstractPathological narcissism is a personality constellation comprising distorted self‐image, maladaptive self‐esteem regulation, and difficulties in intimate relationships. Patients with elevated pathological narcissism may not necessarily meet criteria for narcissistic personality disorder, and may seek treatment for a range of mental health concerns across various clinical settings. An understanding of key principles of control‐mastery theory (CMT) can help clinicians understand the specific goals and challenges of the individual patient with pathological narcissism, and can illuminate ways in which the patient may work in psychotherapy. This paper outlines how patients with pathological narcissism may engage in testing of their pathogenic beliefs, and how therapists can respond in ways that facilitate the patient's sense of safety and foster psychological work. The role of the therapist's attitude is highlighted as a means for countering pathogenic beliefs associated with pathological narcissism. Clinical material from a single case of time‐limited supportive psychotherapy will be used to illustrate these principles and associated therapeutic processes. Insights from CMT regarding pathogenic beliefs and the patient's plan for addressing them can help to explain how therapy works or does not work for patients with pathological narcissism.