bluuebunny/crossref_metadata_2025_split huggingface dataset:
Measurement and spatiotemporal evolution characteristics of dietary diversity among Chinese residents
Authors: Qin Guangyuan , Li Miaomiao , Quan Shiwen 
Published: January 2025

PurposeThe purpose of this paper is to measure the dietary diversity and to analyze the regional characteristics, differences, and evolutionary trends of dietary diversity among Chinese residents.MethodsIn this paper, the dietary diversity among Chinese residents was measured using the Shannon index based on the provincial-level food consumption data from 1995 to 2021. On this basis, the paper employs analysis methods such as kernel density estimation, spatial correlation test, and Dagum’s Gini coefficient to analyze the regional characteristics, differences, and trends of change in dietary diversity.ResultsDuring the study period, the dietary diversity among Chinese residents showed an increasing trend. Among the four major geographic regions, the dietary diversity was highest in the southern region, followed by the northern region, northwest region, and Qinghai-Tibet region. Among the three major economic regions, the dietary diversity was highest in the eastern region, followed by the central region and western region. There was a significant positive spatial correlation in the dietary diversity among Chinese residents, and both high-high agglomeration and low-low agglomeration phenomena were strengthened. In terms of the trend of regional differences, whether overall differences, interregional differences, or intraregional differences, they all showed a shrinking trend. However, interregional differences were the main source of overall differences in dietary diversity among Chinese residents.ConclusionThe dietary diversity among Chinese residents shows an overall increasing trend, and there are regional differences in dietary diversity from the perspectives of economic and geographic regions, which have been narrowing over time.
Burden of NASH related liver cancer from 1990 to 2021 at the global, regional, and national levels
Authors: Li Shuang , Li Shuangjiang , Guan Linjing , Li Mingjuan , Zhao Jiahui , Wu Min , Li Qiuyun , Li Hui , Ouyang Guoqing , Pan Guangdong 
Published: January 2025

BackgroundThe global burden of non-alcoholic steatohepatitis (NASH)-related liver cancer (NRLC) is increasing, making NASH the fastest-growing cause of liver cancer worldwide. This study presents a comprehensive analysis of NRLC burden at the global, regional, and national levels, further categorized by age, sex, and sociodemographic index (SDI).MethodData on NRLC from the Global Burden of Disease, Injuries, and Risk Factors (GBD) study 2021 were downloaded at global, regional, and national levels. The numbers and age-standardized rates (ASRs) of incidence, mortality, and disability-adjusted life years (DALYs) were analyzed to quantify the global burden of NRLC. Additionally, percentage changes in ASRs were used to identify trends in NRLC from 1990 to 2021.ResultsGlobally, both the number of cases and ASRs for NRLC increased between 1990 and 2021. In 2021, there were 42,291 new cases, 40,925 deaths, and 995,475 DALYs attributed to NRLC. East Asia, South Asia, and Southeast Asia reported the highest absolute case numbers, while Western, Southern, and Eastern Sub-Saharan Africa exhibited the highest ASRs. From 1990 to 2021, Australasia, Southern Latin America, and High-income North America showed the most significant increases in NRLC incidence. Nationally, Mongolia, Gambia, and Mozambique exhibited the highest ASR in 2021.The greatest percentage increases in ASIR occurred in Australia, the United Kingdom, and New Zealand between 1990 and 2021. NRLC incidence rates were higher in men and increased with age, peaking at 80–89 years. Similar patterns were observed for NRLC-related deaths and DALYs. Regionally, ASRs initially declined but then increased as SDI rose. At the national level, ASRs consistently decreased with higher SDI.ConclusionThis study highlights the substantial burden of NRLC at global, regional, and national levels. Males and older individuals bear a higher disease burden, and considerable variation exists across different regions and countries. These findings provide critical insights for formulating effective strategies to prevent and manage NRLC.
Association between the dietary inflammatory index and depressive symptoms in adults with metabolic syndrome: a cross-sectional study from the NHANES database
Authors: You Jinshun , Xia Shujie 
Published: January 2025

ObjectiveThe comorbidity of metabolic syndrome (MS) and depressive symptoms has emerged as a growing public health concern, contributing to a substantial global economic burden. The pathogenesis of this comorbidity is thought to be closely linked to inflammation. However, research examining the impact of the Dietary Inflammatory Index (DII) on depressive symptoms in adults with MS remains limited. This study aims to investigate the association between the DII and depressive symptoms in adults with MS, utilizing data from the National Health and Nutrition Examination Survey (NHANES).MethodsThis cross-sectional study included 7,553 participants aged 20 and older MS from six cycles of the NHANES (2007–2018). Depressive symptoms were assessed using the Patient Health Questionnaire scores, and dietary information was gathered to calculate the Dietary Inflammatory Index (DII). The association between DII scores and depressive symptoms in individuals with MS was evaluated through multivariable logistic regression analysis, adjusting for relevant covariates. Subgroup analyses and restricted cubic splines (RCS) were performed to explore this relationship further.ResultsAmong the participants, 907 individuals (12.0%) were identified as having depressive symptoms. After adjusting for all covariates, a positive correlation was observed (OR = 1.09, 95% CI: 1.04–1.14). After adjusting for all covariates, a positive association was observed between DII scores and depressive symptoms (OR = 1.09, 95% CI: 1.04–1.14). Individuals in the highest tertile of DII scores had significantly higher odds of depressive symptoms compared to those in the lowest tertile (OR = 1.36, 95% CI: 1.13–1.65). Subgroup analyses revealed that men were more likely to experience depressive symptoms among adults with MS. The RCS model revealed a nonlinear positive association between DII scores and depressive symptoms in these participants.ConclusionOur study indicates that the DII is positively correlated with an increased likelihood of depressive symptoms among adults with MS in the United States. These findings align with existing research and necessitate further validation through prospective cohort studies.
Detection of postpartum women anemia and its impact on their offspring in Zhejiang Province, China
Authors: He Mengjie , Huang Lichun , Zou Yan , Xu Peiwei , Su Danting , Zhao Dong , Han Dan , Zhang Ronghua 
Published: January 2025

BackgroundInformation on the prevalence of postpartum women anemia is scarce in China, as well as its impact on their offspring. This study aimed to explore the influencing factors of anemia and the impact on the offspring.MethodsA cross-sectional study was conducted among 977 women within 2 years postpartum in 10 sites from 2016 to 2017 in Zhejiang Province, China. Information on demographics, nutrient supplementation and diet was collected. Whole blood hemoglobin, serum ferritin and transferrin receptor were assessed for all women and whole blood hemoglobin was assessed in offspring. The multivariate logistic regression was used to assess the determinants of anemia and the impact on the offspring by calculating odds ratio (OR) and its 95% confidence interval (95%CI).ResultsAmong 977 participants, 144 (14.74%) had anemia. Regression analysis showed that women intaking iron supplements during pregnancy (0.549, 0.350 ~ 0.860), and intaking sufficient red meat (0.647, 0.437 ~ 0.958) had lower rates of anemia, while women wo had anemia during pregnancy (2.754, 1.844 ~ 4.113 for mild anemia, and 3.815, 1.564 ~ 9.309 for moderate or severe anemia), had postpartum over 7 months (1.717, 1.112 ~ 2.650), with abnormal serum ferritin (11.931, 4.846 ~ 29.379) and excessive transferrin receptor levels (1.817, 1.050 ~ 3.145) had higher rates of anemia. Moreover, maternal anemia significantly increases the rate of anemia in offsprings, with ORs being 1.456 (0.994 ~ 2.133) for mild anemia, and 2.961 (1.242 ~ 7.058) for moderate or severe anemia, respectively.ConclusionThe status of anemia in postpartum women was severe and its impact on the anemia of their offspring should be noted. It is highly necessary to strengthen the regular monitoring of hemoglobin levels in pregnant and postpartum women, as well as implement targeted dietary interventions and suggest to intake dietary supplements if necessary.
Association between vitamin D deficiency and major depression in patients with chronic kidney disease: a cohort study
Authors: Chen I-Wen , Wang Wei-Ting , Lai Yi-Chen , Chang Ying-Jen , Lin Yao-Tsung , Hung Kuo-Chuan 
Published: January 2025

BackgroundPatients with chronic kidney disease (CKD) have an elevated risk of both vitamin D deficiency (VDD) and depression. However, the relationship between VDD and the risk of depression in this population remains unclear.MethodsUsing the TriNetX network database (2010–2019), we conducted a propensity score-matched cohort study of CKD patients aged ≥50 years. Patients were categorized into VDD (≤20 ng/mL) and control (≥30 ng/mL) groups based on measurements within 3 months of CKD diagnosis. The primary outcome was the incidence of major depression within 1 year of follow-up.ResultsAmong 17,955 matched pairs, VDD was associated with increased depression risk at 1 year (hazard ratio [HR]: 1.929; 95% confidence interval [CI]: 1.52–2.448; p &lt; 0.0001). This association persisted through 3 years of follow-up. The relationship remained consistent across CKD stages, with similar risks in early (HR:1.977; 95% CI: 1.382–2.829) and CKD stage 3–5 (HR:1.981; 95% CI: 1.533–2.559). Males with VDD showed higher depression risk (HR: 2.264; 95% CI: 1.498–3.421) compared to females (HR:1.761; 95% CI: 1.307–2.374). Even vitamin D insufficiency (20–30 ng/mL) increased depression risk compared to normal levels (HR:1.667; 95% CI: 1.318–2.11). In patients with VDD, cerebrovascular disease, malnutrition, and ischemic heart disease are risk factors for depression.ConclusionVDD is independently associated with increased depression risk in patients with CKD, particularly in males. These findings suggest that maintaining adequate vitamin D levels might be important for mental health in patients with CKD, although randomized trials are needed to confirm whether supplementation can prevent depression in this population.
Mass resection as a candidate treatment for uterine PEComas of uncertain malignant potential: a case report and literature review
Authors: Shi Haijuan , Yin Yan , Liang Shoujun , Liu Chuanzhong , Huang Yibao , Lu Bingfeng , Zhang Liying 
Published: January 2025

BackgroundPerivascular epithelioid cell tumours (PEComas) occurring in the uterus are rare, with surgery being the most recommended primary treatment for malignant cases. This study aims to provide clinical guidance on the clinicopathological features and appropriate treatment options for patients with uterine PEComas of uncertain malignant potential.CasesThis case series summarises the clinical courses of 13 patients diagnosed with uterine PEComas of uncertain malignant potential, including clinical and pathological data as well as their outcomes. We identified one case at our hospital, and data for the other 12 cases were extracted from the PubMed database. The 13 patients were aged 9–75 years, with tumour sizes ranging from 1 to 21 cm, and follow-up times ranging from 2 to 71 months. The most common signs and symptoms included abnormal uterine bleeding (AUB) and abdominal pain. Most of the patients (11/13) were managed surgically without any chemotherapy or radiation therapy. Except for the patients who were lost to follow-up, 11 patients were free of any recurrence or metastasis at their last follow-up. Patients with group A tumours (abundant HMB45 expression) had a longer disease-free survival than those with group B tumours.ConclusionsSurgery alone may be appropriate for uterine PEComas of uncertain malignant potential. Surgical treatment plans should consider the patient’s age, fertility requirements, and personal preferences. Mass resection is a viable treatment option for fertility preservation in reproductive-age patients.
Disease-free survival of 15 years after primary surgery in a patient with advanced high-grade serous ovarian cancer: a case report and literature review
Authors: Shi Yaoqi , Zhu Shuaiying , Shan Jiangjing , Xu Yuhong 
Published: January 2025

BackgroundOvarian cancer, particularly high-grade serous ovarian cancer (HGSOC), is the most lethal gynecological tumor, with most patients experiencing recurrence within 5 years. Long-term survival in HGSOC patients with advanced stages is exceedingly rare.Case summaryWe report a case of advanced HGSOC with exceptional long-term recurrence-free survival following initial treatment. In June 2009, the patient underwent suboptimal cytoreductive surgery for stage IIIC ovarian cancer, including total hysterectomy, bilateral salpingo-oophorectomy, omentectomy, appendectomy, and resection of mesenteric and peritoneal lesions. Postoperatively, residual lesions were observed in the mesenteries and para-aortic lymph nodes. Despite unfavorable prognostic factors (advanced stage, aggressive pathology, and incomplete resection), the patient showed remarkable chemosensitivity, remaining recurrence-free for 15 years.ConclusionThe factors influencing long-term survival in HGSOC patients are not yet fully understood. We present this rare case to contribute data for further studies on long-term survival in advanced HGSOC.
Predicting survival rates: the power of prognostic nomograms in distal cholangiocarcinoma
Authors: Hu Jiangfeng , Shi Yuping , Jin Lihua , Yi Suhong , Chen Jinsuo , Wan Dadong , Ye Weixin , Chen Jingnan , Zhang Yajing , Jiang Yang , Duan Bensong , Dong Yuwei 
Published: January 2025

ObjectiveThe purpose of this research is to establish a prognostic nomogram for patients with distal cholangiocarcinoma (dCCA).MethodsWe obtained clinical data from 2401 patients diagnosed with distal cholangiocarcinoma (dCCA) between 2010 and 2020 from the Surveillance, Epidemiology, and End Results database. These patients were randomly assigned to either the training or validation group in a ratio of 6:4. 228 patients were enrolled from 9 hospitals in China as the external validation cohort. Univariate and multifactorial Cox regression analyses were conducted to ascertain prognostic factors and prognostic nomograms were developed utilizing LASSO logistic regression analysis. We used the calibration curve, and area under the curve to validate the nomograms. Decision curve analysis was used to evaluate the model and its clinical applicability.ResultsThe findings demonstrated that Grade, M stages, Surgery, and Chemotherapy emerged as autonomous prognostic factors for the survival of individuals with dCCA. The developed nomograms exhibited satisfactory accuracy in forecasting 1-year, 3-year, and 5-year survival probabilities. Furthermore, the calibration curves indicated a strong concordance between the anticipated and observed outcomes. The AUC of the nomogram for 1-year, 3-year, 5 year overall survival (OS) predication were 0.809 (95%CI 78.5-83.3), 0.79 (95%CI 75.8-82.2) and 0.761 ((95%CI 72.3-80.0) in the training cohort, 0.79 (95%CI 75.9-82.0), 0.73 (95%CI 68.5-77.5), and 0.732(95%CI 68.0-78.3) in internal test cohort, 0.862 (95%CI 81.7-90.7),0.83 (95%CI 76.4-89.6),and 0.819(95%CI 74.6-89.2) in external test cohort.ConclusionThe nomograms that have been suggested demonstrate strong predictive capability. These tools can assist medical professionals in assessing the prognosis of patients with dCCA and in devising more accurate treatment strategies for them.
Methylation sites of human papillomavirus 16 as potential biomarkers for cervical cancer progression
Authors: Ji Sha , Ji Nannan 
Published: January 2025

ObjectiveTo investigate the methylation levels at 13 specific sites of the human papillomavirus 16 (HPV16) L1 gene as potential biomarkers for the diagnosis of cervical cancer.MethodsSamples were collected from the gynecological outpatient and inpatient departments of the Xinjiang Uygur Autonomous Region People’s Hospital. A total of 107 women participated in this study, including 54 with cervical cancer (32 Uygur, 22 Han) and 53 with cervical inflammation (32 Uygur, 21 Han). Methylation analysis was performed using pyrosequencing to quantitatively assess methylation levels at specified CpG sites within the HPV16 L1 gene.ResultsHigh methylation levels were predominantly observed at sites 5927, 5963 and 6367 in cervical cancer cells compared with inflammatory cells. Methylation patterns exhibited no significant differences between the Han and Uygur ethnic groups but correlated with viral load and age within each group. Receiver operating characteristic curve analyses of these methylation sites indicated high diagnostic accuracy in distinguishing between high-grade lesions and less severe conditions.ConclusionsMethylation of specific CpG sites in the HPV16 L1 gene holds promise as a biomarker for cervical cancer progression. The gene locus at position 6367 has important features in the methylation pattern of cervical cancer, and high accuracy shown in diagnosis make it a potential biomarker for early diagnosis of cervical cancer.
Clinical analysis of different intestinal reconstruction methods after primary cytoreductive surgery combined with rectal resection for advanced ovarian cancer
Authors: Wang Huimin , Li Xiaocen , Jiang Ying , Chen Jinxin , Cao Rong , Zhang Jingru 
Published: January 2025

ObjectiveTo compare different intestinal reconstruction methods after intestinal resection for advanced ovarian malignancy.MethodsRetrospective data of patients with advanced ovarian malignancy were collected and then assigned into three groups: primary intestinal anastomosis, protective enterostomy and colostomy. General clinical characteristics, intraoperative findings and postoperative outcomes were compared between the three groups.ResultsA total of 530 cases were included for final analysis. The colostomy group had a lower serum albumin level, larger volume of ascites, higher likelihood of multiple intestinal resections and lower likelihood of rectal resection, lower peritoneal cancer index, more intraoperative blood loss, transfusions and infusions, lower likelihood of optimal cytoreductive surgery and shorter interval time to chemotherapy than the other two groups (p &lt; 0.05). The primary intestinal anastomosis group exhibited a larger blood transfusion volume, higher incidence rates of anastomotic leak and electrolyte disturbance, and longer times to first flatus, first feeding and drain removal than the other two groups (p &lt; 0.05).ConclusionsColostomy can be adopted for advanced ovarian cancer patients with a large ascites volume, hypoproteinemia, large intraoperative blood and fluid loss volumes, multiple intestinal resections, anastomoses located below the peritoneal reflection, high PCI and suboptimal cytoreductive surgery. For patients with good intraoperative and postoperative outcomes, one anastomosis, an anastomosis located above the peritoneal reflection, low PCI or optimal cytoreductive surgery, intestinal anastomosis can be carried out to restore the normal physiological function of the intestine. For patients with a large volume of ascites (≥500 mL), multiple anastomoses or an anastomosis located below the peritoneal reflection, intestinal anastomosis combined with protective enterostomy has an advantage over intestinal anastomosis alone.
Effect of drug interactions with apixaban on clinical outcomes in cancer patients with venous thromboembolism
Authors: Svalastoga Marte , Larsen Trine-Lise , Brekke Jorunn , Enden Tone , Frøen Hege , Garresori Herish , Jacobsen Eva Marie , Porojnicu Alina Carmen , Ree Anne Hansen , Torfoss Dag , Velle Elin Osvik , Wik Hilde Skuterud , Ghanima Waleed , Sandset Per Morten , Dahm Anders Erik Astrup 
Published: January 2025

IntroductionIt is unclear how drug-interaction with apixaban influences recurrent venous thromboembolism (VTE) and bleedings in cancer patients.MethodsA post-hoc analysis of a single-arm interventional clinical trial on apixaban treatment of cancer patients with VTE to investigate whether the occurrence of any of the endpoints could be associated with the concurrent use of an interacting drug. Drugs taken by the patients during the trial period were categorized as either increasing bleeding risk, increasing thrombosis risk, both or neither.Results298 patients were divided into groups based on whether they used no interacting drugs (controls, n=74), drugs increasing bleeding risk (n=55), drugs increasing thrombosis risk (n=8), or both (n=161). Odds ratios (OR) were calculated for recurrent VTE, clinically relevant non-major bleeding (CRNMB), and major bleeding during the 36-month follow-up period. Each patient took a median of 13 different drugs over the study period. 67% of the patients used drugs expected to both increase bleeding and thrombosis. The use of fluconazole appeared associated with CRNMB (OR 3.6, 95% confidence interval (CI) 0.99-13), but not with major bleeding (OR 0.56, 95% CI 0.06 - 4.8). Non-steroid anti-inflammatory drugs were not associated with CRNMB (OR 1.0, 95% CI 0.25-4.1) or major bleedings (OR 0.72, 95% CI 0.14 - 3.6). Use of antiplatelet therapy was not associated with CRNMB (OR 0.75, 95% CI, 0.22 - 2.58) or major bleeding (OR 0.2, 95% CI, 0.02-1.6). There were no major bleedings in 23 patients using aprepitant nor in the 10 patients taking macrolides. We found no association between drugs and recurrent VTE, except that there were no recurrent VTE in 19 patients using bevacizumab.ConclusionsDespite the high number of drugs taken that could potentially interact with apixaban, none were found to clearly influence clinical outcomes, except that fluconazole may increase the risk of CRNMB.