bluuebunny/crossref_metadata_2025_split huggingface dataset:
A newly-synthesized compound CP-07 alleviates microglia-mediated neuroinflammation and ischemic brain injury via inhibiting STAT3 phosphorylation
Authors: Guo Mengdi , Cao Qian , Xia Shengnan , Cao Xiang , Chen Jian , Qian Yi , Bao Xinyu , Xu Yun 
Published: October 2023

Abstract

Background and Objectives
Overactivated glial cells, especially microglia, are core components in the progression of pathologic neuroinflammation, and the application of anti-inflammatory reagents has been regarded as a potential therapy in the management of infarction/reperfusion (I/R) brain injury. This research aims to clarify the anti-inflammatory efect of a novel lipophilic compound N-(2-[4-tert-butylphenyl]-2-[pyrrolidine-1-yl]ethyl)-7-methyl-4-oxo-4H-chromene-2-carboxamide (named CP-07 in this study) in LPS-stimulated BV2 cell line and primary mouse microglia, and its therapeutic effect on I/R brain injury.

Method
Cell Counting Kit-8 assay was used to determine the maximal nontoxic dose of CP-07. The mRNA levels of representative proinflammatory cytokines were determined by quantitative real-time polymerase chain reaction both in vitro and in vivo. TTC staining was performed to calculate infarct volumes while behavioral tests were used to assess the neurological deficits at 24 h after middle cerebral artery occlusion (MCAO). Flow cytometry analysis and immunofluorescence staining were performed to calculate the percentage of pro-inflammatory microglia in vivo.A selective JAK2/STAT3 pathway inhibitor, AG490 was used to block STAT3 phosphorylation before the CP-07 anti-inflammation tests in vitro.

Results
CP-07 could effectively suppress the mRNA levels of IL-6, IL-1β, iNOS and TNF-α induced by lipopolysaccharide (LPS) in vitro, and markedly block the evaluation of the fluorescence intensity of Iba-1 in primary mouse microglia. In middle cerebral arteryocclusion models, intraperitoneal injection with 1 mg/kg CP-07 significantly reduced cerebral infarct volumes at 24 h after surgery compared with vehicle treatment group, and promoted the recovery of neurological functions in MCAO mice. Further studies validated that CP-07 administration reduced the percentage of CD86 positive microglia after I/R injury, and the expression level of p-STAT3 was also markedly reduced in both microglial cells and the penumbra tissues. Blocking STAT3 phosphorylation with AG490 could completely eliminate the anti-inflammatory effects of CP-07, at least in vitro.

Conclusion
We showed that a newly synthesized compound, CP-07, could effectively reduce the inflammatory responses in LPS-stimulated BV2 cells and primary mouse microglia, and overproduction of cytokines in middle cerebral artery occlusion mouse models by inhibiting STAT3 phosphorylation, leading to a neuroprotective effect on I/R brain injury.
Challenges and Opportunities of the Role of the Social Educator in the Context of São Tomé and Príncipe
Authors: Dos Santos Olga Maria Assunção Pinto 
Published: October 2023

Theoretical benchmark: Starting from a theoretical framework that addresses the multiplicity of roles inherent to the Social Educator, we wanted to understand the work developed by five undergraduate interns from the Social Education course at a higher education institution in Portugal, who stayed for four months, February to May, in the 2019/2020 and 2020/2021 academic years in various institutions, in São Tomé and Príncipe.

Method: Qualitative study, informed by descriptive and interpretative characteristics, seeks to understand and describe behaviors, feelings and ways of thinking and acting of the subjects participating in the study.

Results and conclusion: The paths followed by the interns, in their multiple roles, were an added value, making visible the importance of the role of the Social Educator in developing countries and, in particular, in the exercise of full citizenship in demanding and complex contexts that are aggravated by the COVID-19 pandemic. Therefore, it is called for an increase in internships in the context of international cooperation, in developing countries.
Research implications: Need for the Social Education technician in developing countries, and especially in São Tomé and Príncipe.

Originality/value: Research carried out in São Tomé and Príncipe to highlight the valorization of the role of women, since this group was only female, in order to contribute to the reduction of socio-educational problems, associated with female and child poverty, which they still have a lot of expression on the Island of São Tomé and Príncipe.
Pattern of Adolescents Happines in Islamic Boarding Schools: Examine The Role of Self Acceptance and Prosocial Behavior
Authors: Albab Muhamad Ulul , Rina Amherstia Pasca 
Published: October 2023

This study aims to determine the relationship between self-acceptance and prosocial behavior with happiness in adolescents at the Assalafi Al Fithrah Islamic boarding school Surabaya. This study used quantitative research with a total of 150 subjects. The sampling technique in this study is a random sampling technique. The research sample included in this study was adolescents aged 12-18 years who lived in the one of Islamic boarding school in Surabaya with 73 male and 77 female subject. Based on the calculation of the results of the analysis using Multiple Linear Regression Analysis, a correlation score of 0.772 was obtained with a significance of p = 0.000 (p < 0.05) which means that there is a relationship between self- acceptance and prosocial behavior with happiness. Meanwhile, a correlation score of 0.507 was obtained with a significance of 0.000 (p<0.05) which means that there is a positive relationship between self-acceptance and happiness. The correlation score of prosocial behavior with happiness was 0.487 with a significance of 0.000 (p<0.05). As a result, the higher the self-acceptance and prosocial behavior possessed by adolescents, the higher the level of happiness they feel. The effective contribution in this study was 0.487, which means that self-acceptance and prosocial behavior have an influence of 48.7% on happiness.
ABSTRAK
Penelitian ini bertujuan untuk mengetahui hubungan penerimaan diri dan perilaku prososial dengan kebahagiaan pada remaja di pondok pesantren Assalafi Al Fithrah Surabaya. Penelitian ini menggunakan penelitian kuantitatif dengan jumlah 150 subyek. Teknik penarikan sampel dalam penelitian ini adalah teknik random sampling. Sampel penelitian yang diturut sertakan dalam penelitian ini yaitu remaja berusia 12 – 18 tahun yang tinggal di dalam lingkungan pondok pesantren Assalafi Al Fithrah Surabaya. Berdasarkan perhitungan hasil analisis menggunakan Analisis Regresi Linier Berganda diperoleh skor korelasi sebesar 0.772 dengan signifikansi p=0.000 (p<0.05) yang artinya ada hubungan antara penerimaan diri dan perilaku prososial dengan kebahagiaan. Sementara itu diperoleh skor sebesar 0.507 dengan signifikansi 0.000 (p<0.05) yang artinya terdapat hubungan posistif antara penerimaan diri dan kebahagiaan. Skor korelasi perilaku prososial dengan kebahagiaan sebesar 0.487 dengan signifikansi 0.000 (p<0.05). Hasilnya, semakin tinggi penerimaan diri dan perilaku prososial yang di miliki oleh remaja maka akan semakin tinggi pula tingkat kebahagiaan yang di rasakannya. Sumbangan efektif dalam penelitian ini sebesar 0.487 yang artinya penerimaan diri dan perilaku prososial memiliki pengaruh sebesar 48,7% terhadap kebahagiaan.
Pengaruh Mekanisme Good Corporate Governance (Gcg) Terhadap Kinerja Keuangan Perusahaan Sebelum Masa Pandemi Covid-19
Authors: Khairunnisa  , Besli Eugenius 
Published: October 2023

This research was conducted to determine the effect of Good Corporate Governance (GCG) on company performance in manufacturing companies listed on the Indonesian stock exchange in 2017-2019. This study aims to determine the correlation that occurs between the independent variables and the dependent variable. The population used in this study are all manufacturing companies listed on the Indonesia Stock Exchange (IDX). The selection of the research sample used a purposive sampling method with a total of 183 companies registered. Good Corporate Governance (GCG) in this study is described by the variables of managerial ownership, institutional ownership, board of commissioners and audit committees, while company performance is described by Return On Assets (ROA). The data used in this study are annual reports issued by companies listed on the IDX website. Testing the data in this study using SPSS. The results of the study show that managerial ownership, institutional ownership, the board of commissioners and the audit committee have an influence on the company's financial performance.
Keywords: Managerial Ownership, Institutional Ownership, Board of Commissioners, Audit Committee, and Return On Assets (ROA).
Analisis Penerapan Sistem Informasi Akuntansi Pada Penggunaan Dana Bantuan Operasional Sekolah
Authors: Listyono Putro Rizki , Najib M.Toha Ainun 
Published: October 2023

Dana BOS yaitu program pemerintah yang membantu sekolah di seluruh Indonesia, antuan ini didistribusikan berdasarkan jumlah peserta didik yang terdaftar. Sekolahan dalam mengajukan dana BOS harus membuat rancangan perencanaan yang dimasukkan ke dalam Rencana Kegiatan dan Anggaran Sekolah (RKAS). Penelitian ini bertujuan untuk menganalisis terkait penggunaan sistem informasi akuntansi yang diterapkan untuk mengelola pemasukan dan pengeluaran kas di Sekolah Dasar berfungsi dengan baik serta sesuai dengan petunjuk teknis BOS. Subjek penelitian dalam studi ini yaitu Sekolah Dasar Negeri Singkil, yang terletak di kecamatan Balong Kabupaten Ponorogo. Kepala sekolah, bendahara, guru, dan komite sekolah adalah sumber data penelitian. Penelitian ini menerapkan metode deskriptif kualitatif. Pengumpulan datanya dengan cara wawancara, observasi, dan dokumentasi. Teknik tringulasi sumber digunakan untuk menguji validitas dan keabsahan data dalam penelitian. Hasil penelitian menunjukkan bahwa sekolah telah melaksanakan perencanaan RKAS sesuai dengan persyaratan petunjuk teknis BOS Kemendikbud. Bendahara, guru, dan komite sekolah dilibatkan dalam proses perencanaan RKAS. Pelaksanan pengelolaan dana BOS diperlukan penambahan sumber daya manusia (SDM), hal ini bertujuan untuk menghasilkan hasil yang lebih baik. Untuk menghindari kecurangan maka subunit pengendalian internal harus dibuat, serta fungsi akuntansi dan fungsi keuangan perlu dipisahkan.
Longitudinal Course of Long Finger Flexor Shortening in Males with Duchenne Muscular Dystrophy: A Retrospective Review
Authors: Houwen-van Opstal Saskia L.S. , van der Holst Menno , Willemsen Michel A.A.P. , Niks Erik H. , De Groot Imelda. J.M. , Cup Edith H.C. 
Published: October 2023

BACKGROUND: Shortening of the long finger flexors (Flexor Digitorum Profundus, FDPs) in Duchenne Muscular Dystrophy (DMD) causes reduced hand function. Until now, longitudinal studies on the natural course of the shortening of the FDPs are lacking, which impedes recommendations on timing and evaluation of preventive measures. OBJECTIVE: To investigate the longitudinal course of the FDP length during different disease stages focusing on symmetry, timing, and decline of the FDP length. METHODS: A retrospective, longitudinal multicenter study was conducted in the Radboud university medical center and the Leiden university medical center. The FDP outcome was measured using goniometry and gross motor function was assessed using the Brooke score. Longitudinal mixed model analyses were used to describe the course of the FDP outcome, and to investigate symmetry in both hands. RESULTS: Data on 534 visits of 197 males (age ranged 4–48 years) showed that in the ambulatory stages the FDP outcome was within a normal range. The mean decline in FDP outcome is 3.5 degrees per year, the biggest decline was seen in Brooke 5 (>15 degrees per year). In Brooke 4, 41% of the FDP outcome was < 40 degrees. No significant differences were found between right and left. CONCLUSIONS: This study supports the consideration of preventive measures to delay shortening of the FDPs in DMD patients transitioning to a Brooke scale of 4 or higher. Besides, natural history of FDP outcome has been established, which provides a base to evaluate (preventive) interventions.
Adherence to the Mediterranean diet and prostate cancer severity
Authors: Sciacca Salvatore , Lo Giudice Arturo , Asmundo Maria Giovanna , Cimino Sebastiano , Alshatwi Ali A. , Morgia Giuseppe , Ferro Matteo , Russo Giorgio Ivan 
Published: October 2023

BACKGROUND: Prostate cancer (PCa) is a significant health concern, and its incidence and prevalence are influenced by various lifestyle factors, including diet. In recent years, the Mediterranean diet has gained popularity due to its potential health benefits and associations with reduced risk for various diseases. However, the impact of the Mediterranean diet on PCa remains a topic of debate. OBJECTIVE: The aim of this study was to test the association between adherence to the Mediterranean diet and PCa severity. METHODS: Background, clinical and dietary information (from food frequency questionnaires) were collected from 118 consecutive patients attending a university hospital in Southern Italy. Multivariate logistic regression analyses were used to calculate odds ratios (ORs) and 95% confidence intervals (CIs) to test the associations. RESULTS: Patients reporting higher adherence to the Mediterranean diet were less likely to have more at risk PCa both when comparing intermediate/high vs. low risk and high vs. intermediate /low risk PCa (OR = 0.12, 95% CI: 0.02, 0.85 and OR = 0.05, 95% CI: 0.01, 0.31, respectively). CONCLUSIONS: In conclusion, higher adherence to the Mediterranean diet may be associated with a clinically less severe clinical PCa.
The effects of ALK5 inhibition and simultaneous inhibition or activation of HIF-1α in melanoma tumor growth and angiogenesis
Authors: Zarin Bahareh , Nedaeinia Reza , Laher Ismail , Manian Mostafa , Javanmard Shaghayegh Haghjooy 
Published: October 2023

BACKGROUND: Hypoxia is the most common signature of the tumor microenvironment that drives tumorigenesis through the complex crosstalk of a family of transcription factors called hypoxia-inducible factors (HIFs), with other intercellular signaling networks. Hypoxia increases transforming growth factor-beta (TGF-β) expression. TGF-β and HIF-1α play critical roles in several malignancies and their interactions in melanoma progression remain unknown. Therefore, the aim of this study was to assess the impact of inhibiting activin receptor-like kinase-5 (ALK5), a TGF-β receptor, on the response to HIF-1α activation or inhibition in melanoma tumor progression. MATERIALS AND METHODS: Tumors were induced in C57BL/6J mice by subcutaneous inoculation with B16F10 melanoma cells. Mice were divided into HIF-1α inhibitor, ALK5 inhibitor (1 mg/kg) and HIF-1α inhibitor (100 mg/kg), ALK5 inhibitor, HIF-1α activator (1000 mg/kg), HIF-1α activator and ALK5 inhibitor, and control groups to receive inhibitors and activators through intraperitoneal injection. The expression of E-cadherin was evaluated by RT-qPCR. Vessel density and platelet-derived growth factor receptor beta (PDGFR)-β+ cells around the vessels were investigated using immunohistochemistry. RESULTS: The groups receiving HIF-1α inhibitor and activator showed lower and higher tumor growth compared to the control group, respectively. E-cadherin expression decreased in all groups compared to the control group, illustrating the dual function of E-cadherin in the tumor microenvironment. Vascular density was reduced in the groups given HIF-1α inhibitor, ALK5 inhibitor, and ALK5 and HIF-1α inhibitor simultaneously. The percentage of PDGFR-β+ cells was reduced in the presence of HIF-1α inhibitor, ALK5 inhibitor, HIF-1α and ALK5 inhibitors, and upon simultaneous treatment with HIF-1α activator and ALK5 inhibitor. CONCLUSION: Despite increased expression and interaction between TGF-β and HIF-1α pathways in some cancers, in melanoma, inhibition of either pathway alone may have a stronger effect on tumor inhibition than simultaneous inhibition of both pathways. The synergistic effects may be context-dependent and should be further evaluated in different cancer types.
STRATEGI PENGEMBANGAN USAHA MELALUI PEMASARAN DIGITAL PADA UMKM ESHAN.ID_ BEJI DEPOK
Authors: Silaningsih Endang , Fitriyani Elma , Alfahri Hasanudin , Kartini Tini 
Published: October 2023

UMKM play an important role in the economy in Indonesia. UMKM can play a role in improving people's welfare as a means of equalizing the economic level of the common people, a means of alleviating poverty and a means of earning foreign exchange for the country.
Despite the importance of the contribution of UMKM to the national economy, it turns out that this sector still has many problems, one of which is the weakness of UMKM in marketing their products. The purpose of community service is to provide assistance to UMKM related to the use of digital technology to increase product sales, especially to UMKM Eshan.id_. Ehsan.id_ UMKM is a business in the field of knitting handicrafts, which in 2022 has achieved an income target of only 63.05%, so it is necessary to determine the right strategy in marketing its products, such as through digital marketing. The assistance is intended so that UMKM can take advantage of social media to increase sales by creating social media content on Instagram and Tiktok. The result of this activity is the giving of meaning and philosophy to the logo to meet the requirements for making IPR (Intellectual Property Rights) and also a company profile that can be used by UMKM in conducting product marketing. In addition, UMKM owners also receive education regarding the theory of digital product marketing through social media that is effective and right on target
Identifikasi Telur Cacing Trichostrongylus Spp. Pada Feses Kuda Penarik Cidomo Di Pasar Kecamatan Masbagik Kabupaten Lombok Timur
Authors: Buana Givary Hatamy Wanta , Ningtyas Novarina Sulsia Ista'In , Janah Maratun 
Published: October 2023

Kuda merupakan salah satu binatang peliharaan yang di gunakan sebagai alat transportasi di beberapa daerah di Indonesia. selain sebagai tenaga penarik delman, kuda dapat sekaligus menjadi tenaga penarik gerobak dan kuda beban. Gastrointestinal Parasites (GIP) masih menjadi masalah utama yang mempengaruhi kesehatan dan kesejahteraan kuda di berbagai belahan dunia. Salah satu nematoda gastrointestinal adalah Trichostrongylus spp. yang dapat bersifat zoonosis atau menular dari hewan ke manusia. Peneliti ini bertujuan untuk mengidentifikasi Telur cacing Trichostrongylus spp pada feses kuda penarik cidomo sehingga dapat menjadi dasar untuk merancang usaha pencegahan dan pengobatan yang efektif dan efisien. Penelitian ini dilakukan pada bulan agustus 2023. Metode yang digunakan di dalam pemeriksaan sampel feses kuda adalah metode natif dan apung. Pemeriksaan sampel dilakukan di laboratorium Parasitologi dan Mikrobiologi Fakultas Kedokteran Hewan Universitas Pendidikan Mandalika. Hasil pemeriksaan pada 20 sampel feses kuda cidomo yang diambil di Pasar Kecamatan Masbagik Kabupaten Lombok Timur didapatkan sampel yang positif terinfeksi Trichostrongylus spp. sebanyak 4 sampel dengan kondisi bulu kusam dan kurus yang memiliki rata-rata panjang 83.079 μm dan lebar 39.286 μm.
Association between systemic immune-inflammation index and diabetes: a population-based study from the NHANES
Authors: Nie Yiqi , Zhou Haiting , Wang Jing , Kan Hongxing 
Published: October 2023

BackgroundSystemic Immune-Inflammation Index (SII) has been reported to be associated with diabetes. We aimed to assess possible links between SII and diabetes.MethodsData were obtained from the 2017-2020 National Health and Nutrition Examination Survey (NHANES) database. After removing missing data for SII and diabetes, we examined patients older than 20 years. Simultaneously, the relationship between SII and diabetes was examined using weighted multivariate regression analysis, subgroup analysis, and smooth curve fitting.ResultsThere were 7877 subjects in this study, the average SII was 524.91 ± 358.90, and the prevalence of diabetes was 16.07%. Weighted multivariate regression analysis found that SII was positively associated with diabetes, and in model 3, this positive association remained stable (OR = 1.04; 95% CI: 1.02–1.06; p = 0.0006), indicating that each additional unit of SII, the possibility of having diabetes increased by 4%. Gender, age, BMI, regular exercise, high blood pressure, and smoking did not significantly affect this positive link, according to the interaction test (p for trend&gt;0.05).DiscussionAdditional prospective studies are required to examine the precise connection between higher SII levels and diabetes, which may be associated with higher SII levels.
Revisiting the usefulness of the short acute octreotide test to predict treatment outcomes in acromegaly
Authors: Marques-Pamies Montserrat , Gil Joan , Valassi Elena , Hernández Marta , Biagetti Betina , Giménez-Palop Olga , Martínez Silvia , Carrato Cristina , Pons Laura , Villar-Taibo Rocío , Araujo-Castro Marta , Blanco Concepción , Simón Inmaculada , Simó-Servat Andreu , Xifra Gemma , Vázquez Federico , Pavón Isabel , García-Centeno Rogelio , Zavala Roxana , Hanzu Felicia Alexandra , Mora Mireia , Aulinas Anna , Vilarrasa Nuria , Librizzi Soledad , Calatayud María , de Miguel Paz , Alvarez-Escola Cristina , Picó Antonio , Sampedro Miguel , Salinas Isabel , Fajardo-Montañana Carmen , Cámara Rosa , Bernabéu Ignacio , Jordà Mireia , Webb Susan M. , Marazuela Mónica , Puig-Domingo Manel 
Published: October 2023

IntroductionWe previously described that a short version of the acute octreotide test (sAOT) can predict the response to first-generation somatostatin receptor ligands (SRLs) in patients with acromegaly. We have prospectively reassessed the sAOT in patients from the ACROFAST study using current ultra-sensitive GH assays. We also studied the correlation of sAOT with tumor expression of E-cadherin and somatostatin receptor 2 (SSTR2) .MethodsA total of 47 patients treated with SRLs for 6 months were evaluated with the sAOT at diagnosis and correlated with SRLs’ response. Those patients whose IGF1 decreased to &lt;3SDS from normal value were considered responders and those whose IGF1 was ≥3SDS, were considered non-responders. The 2 hours GH value (GH2h) after s.c. administration of 100 mcg of octreotide was used to define predictive cutoffs. E-cadherin and SSTR2 immunostaining in somatotropinoma tissue were investigated in 24/47 and 18/47 patients, respectively.ResultsIn all, 30 patients were responders and 17 were non-responders. GH2h was 0.68 (0.25-1.98) ng/mL in responders vs 2.35 (1.59-9.37) ng/mL in non-responders (p&lt;0.001). GH2h = 1.4ng/mL showed the highest ability to identify responders (accuracy of 81%, sensitivity of 73.3%, and specificity of 94.1%). GH2h = 4.3ng/mL was the best cutoff for non-response prediction (accuracy of 74%, sensitivity of 35.3%, and specificity of 96.7%). Patients with E-cadherin-positive tumors showed a lower GH2h than those with E-cadherin-negative tumors [0.9 (0.3-2.1) vs 3.3 (1.5-12.1) ng/mL; p&lt;0.01], and patients with positive E-cadherin presented a higher score of SSTR2 (7.5 ± 4.2 vs 3.3 ± 2.1; p=0.01).ConclusionThe sAOT is a good predictor tool for assessing response to SRLs and correlates with tumor E-cadherin and SSTR2 expression. Thus, it can be useful in clinical practice for therapeutic decision-making in patients with acromegaly.