bluuebunny/crossref_metadata_2025_split huggingface dataset:
Evolutionarily new genes in humans with disease phenotypes reveal functional enrichment patterns shaped by adaptive innovation and sexual selection.
Authors: chen jianhai 
Published: November 2023

Abstract
New genes (or young genes) are structural novelties pivotal in mammalian evolution. Their phenotypic impact on humans, however, remains elusive due to the technical and ethical complexities in functional studies. Through combining gene age dating with Mendelian disease phenotyping, our research reveals that new genes associated with disease phenotypes steadily integrate into the human genome at a rate of ~ 0.07% every million years over macroevolutionary timescales. Despite this stable pace, we observe distinct patterns in phenotypic enrichment, pleiotropy, and selective pressures between young and old genes. Notably, young genes show significant enrichment in the male reproductive system, indicating strong sexual selection. Young genes also exhibit functions in tissues and systems potentially linked to human phenotypic innovations, such as increased brain size, bipedal locomotion, and color vision. Our findings further reveal increasing levels of pleiotropy over evolutionary time, which accompanies stronger selective constraints. We propose a “pleiotropy-barrier” model that delineates different potentials for phenotypic innovation between young and older genes subject to natural selection. Our study demonstrates that evolutionary new genes are critical in influencing human reproductive evolution and adaptive phenotypic innovations driven by sexual and natural selection, with low pleiotropy as a selective advantage.
Dynamic time history analysis of RC frame structures considering damage in the non-principal axis direction
Authors: GAO Chongming , LI Zhenbao , LI Mushan , ZHANG Liang , MA Hua 
Published: November 2023

Abstract
To investigate the damage mechanism of RC frame structures in the non-principal axis direction under seismic loading, low cyclic loading tests were carried out on spatial beam-column joints loaded along the principal axis direction and non-principal axis direction, the finite element analysis and test failure characteristics are compared. The RC frame model was then developed and dynamic time analysis was carried out on the model to investigate the plastic strain, inter-story displacement angle, and base shear force of the frame in the principal axis and non-principal axis direction. The results show that: when seismic waves are input along the principal axis of the structure, plastic hinges are likely to appear at the beam ends, forming damage to the beam hinge mechanism; when seismic waves are input along the non-principal axis of the structure, damage to the column hinge mechanism is likely to form. Under the excitation of different seismic waves, the inter-story displacement angle of the structure in the principal axis and non-principal axis directions can increase by a maximum of 41.2% and the base shear force of the structure along the principal and non-principal axis directions can increase by a maximum of 45.1%. The above results can indicate that the overall deformation needs of the structure are greater when the seismic waves are input in the non-principal axis direction, when the seismic wave is input along the principal axis direction of the structure, the lateral stiffness of the structure is improved. The results of the paper can provide a reference for the seismic design of RC structures in the non-principal axis direction.
Mechanical properties of segmented utility tunnels with ground fissure dislocation
Authors: Liu Xiaoxiao , Liu Xi , Huang Hua , Liu Ruiyang , Zeng Jie 
Published: November 2023

Abstract
Underground utility tunnels provide essential services to the urban population and solve the problem of the shortage of overground space. Although segmented utility tunnels suffer less force and bending moment, their response due to soil movement is more complex, especially when the tunnel crosses the ground fissure zone. This paper investigates segmented utility tunnels' deformation and stress response under different ground fissure dislocations through 3D finite element (FE) simulation. A segmented utility tunnel in Xingfu Forest Belt in Xi’an city, China, is employed as the research object. The simulation results show that, under the orthogonal condition (the utility tunnel orthogonally crosses the ground fissure), the main deformation area of the tunnel was within the range of 30-80m along the longitudinal direction (about 30m away from the ground fissure in the hanging wall and 20m in the footwall). The tunnel showed bending and shear characteristics. The main compression area of the tunnel was mainly concentrated within the hanging wall near the ground fissure, and the stress in the other area was low and generally not changed. Under the oblique condition (the utility tunnel obliquely crosses the ground fissure with an angle of 60°), the main deformation area of the tunnel was within the range of 45-80m along the longitudinal direction (about 15m away from the ground fissure in the hanging wall and 20m in the footwall), and the tunnel showed combined bending-shearing-torsion characteristics. The stress at the tunnel junction changed sharply when crossing the ground fissure. Concurrently, the left warehouse of the tunnel, which was larger than the right warehouse subjected to greater vertical stress. This study provides some reference for the structural design of the segmented utility tunnels when it crosses the ground fissures.
Strategy for Revisit Intention Saba Baduy Culture
Authors: Supryadi Didy Ika , Handika Taufan , Asih Daru , Sutanto Himawan , Patiro Shine Pintor Siolemba , Morales Dori Heza 
Published: November 2023

Objective: The purpose of this study was to examine the effect of Service Quality, Destination Image, and Local Wisdom on Revisiting Saba Baduy Culture with Electronic Word of Mouth as an intervening variable.Methodology: This research was conducted using primary data, namely by distributing questionnaires online via Google form and disseminating through social media, namely Instagram, Line, and WhatsApp. The sampling technique used was purposive sampling. The population in this study was 115 respondents who were visitors to Saba Baduy spread across the Jakarta, Bogor, Bekasi, and Tangerang areas. The data was processed using Partial Least Square (Smart-PLS) version 3.2.9.Finding: The Baduy people are very careful with their customs and protect the natural surroundings. As they are aware that they live with nature and coexist with nature. The original Baduy tribe consists of the Inner Baduy and Outer Baduy. The Baduy tribe still maintains traditions, and customs and is anti-modern in terms of clothing, lifestyle, and others.Conclusion: An interesting conclusion found that when stakeholders build adequate infrastructure, this becomes something that does not reflect the authenticity of Baduy culture itself. On the other hand, tourists who want to return to the Baduy Traditional Villages since they want to experience nature which is still beautiful and serene, see the unique culture and local wisdom which is still very traditional, and experience the lifestyle of the Baduy people without modernization as it is seen as unique and interesting.
Financial Performance, Debt-to-Equity Ratio, Return on Assets, and Total Asset Turnover on Earnings Per Share and Stock Price as Moderator
Authors: Satoto Eko Budi , Marjohan Masno , Suyanto Suyanto 
Published: November 2023

Objectives: This paper sought to undertake a comprehensive analysis aimed at investigating the influence arising from the various financial metrics, namely the Current Ratio, Debt-to-Equity Ratio, Return On Assets, and Total Assets Turnover on Earnings Per Share (EPS), and Stock Prices as the moderating variable. Methodology: This research employs a quantitative descriptive methodology by collecting financial reports of Food and Beverage companies listed on the Indonesia Stock Exchange (BEI). The measurement model and hypothesis testing are Descriptive Statistics with a Panel Data Regression Model Selection.Finding: The study found that the Current Ratio had no significant direct effect on Earnings Per Share (EPS), while the Debt to Equity Ratio, Return on Assets, and Total Assets Turnover all had varying degrees of negative influence on EPS via Stock Price. The combined impact of these metrics was statistically significant, emphasizing the importance of considering multiple factors when assessing financial performance.Conclusion: The use of predictive models to forecast stock performance based on these factors can offer significant benefits to both investors and company management. Moreover, this research can aid in the development of better financial metrics, more effective risk management, smarter investment strategies, and an interdisciplinary approach to understanding the complex relationships between financial factors and stock prices. All of this will provide more robust tools for evaluating company performance and making better investment decisions in the world of investments.
Seberapa efektif peregangan dengan PNF terhadap kelenturan
Authors: Samodra Y. Touvan Juni , Yosika Ghana Firsta , AL Fajar Hafis Hafis 
Published: November 2023

Masalah: Kelenturan menjadi perhatian sebelum dan setelah melaksankan kegiatan olahraga. Kelenturan yang kurang dalam ruang gerak sendi akan memberikan kerugian pada pelaku olahraga. Kelenturan ini disamping upaya pencegahan terhadap terjadinya cidera juga mampu meningkatkan kekuatan atupun power.
Tujuan: Pembuktian efektifitas peningkatankelenturan denganmenggunakan Peragangan PNF.
Metode: Metode penelitian dengan menggunakan eksperimen One Group Pretest- Postest design. Sampel yang digunakan adalah mahasiswa/i Universitas Tanjungpura Prodi Pendidikan Kepelatihan Olahraga berjumlah 10 orang. Penelitian ini dilakukan dengan menggunakan treatmeant 3 gerakan stretching PNF, dengan gerakan Hold Relax Hamstring, Quadriceps, Chest PNF. Penekanan dilakukan setelah ada rasa sakit kemudian di pertahankan selama 30 detik, baru kemudian ke gerakan selanjutnya. Perlakuan diulang sampai tiga kali setiap gerakan. Kelenturan diukur dengan sit and reach sebelum dan sesudah perlakuan (treatmeant). Teknik analisis data menggunakan deskriptif dan uji t..
Hasil: Berdaarkan data yang diperolah ternyata terdapat peningkatan kelenturan sebelum dan setelah dilakukan perlakukan dengan rerata peningkatan kelenturan sampia 11,8 cm. Maka dengan dapat simpulkan bahwa dengan adanya peregangan PNF dapat meningkatkan kelenturan.
Kesimpulan: Implikasi selanjutnya penerapan peregangan dengan prosedur PNF lebih disarankan untuk meningkatkan kelenturan.
Perencanaan Strategis Sistem Informasi Pada PT. Prawira Swastika
Authors: Mardiana Dwi 
Published: November 2023

Persaingan bisnis saat ini semakin tinggi, PT. Prawira Swastika sebuah perusahaan yang bergerak dibidang pengiriman barang yang memerlukan sistem informasi dalam menunjang kinerja perusahaan. Tujuan penelitian adalah membuat suatu perencanaan strategis sistem informasi yang mampu memberikan dukungan terhadap berbagai kegiatan bisnis perusahan. Penelitian ini menggunakan metode yaitu wawancara dengan berbagai pihak-pihak, menyebarkan kuesioner yang diisi oleh para karyawan perusahaan, mengobservasi langsung berbagai kegiatan melakukan studi literatur. Metode analisis PEST, Lima Daya Porter, SWOT, Value Chain, CSF dan KPI, Audit Gris digunakan dalam menganalisis strategi perusahaan. Adapun Tahapan Kerangka Kerja PSI versi John Ward digunakan dalam tahap perencanaan strategis. Penelitian ini memperoleh hasil kerangka perencanaan strategi yang terintegrasi sehingga dapat mempermudah pihak manajemen dalam melakukan pengelolaan sumber daya guna mendapatkan hasil informasi yang akurat dan sesuai dengan kebutuhan serta bisa dipergunakan bersama-sama oleh semua pihak. Kesimpulan dari penelitian ini adalah pembangunan sistem informasi yang berbasis komputer mampu memberikan dukungan dalam memperlancar berbagai kegiatan proses bisnis pengiriman barang PT. Prawira Swastika
Comparative Long-chain Polyunsaturated Fatty Acids Levels in Blood, Placenta and Cord Blood of Pregnant Women with or without Pre-eclampsia
Authors: Weili Zhang 
Published: November 2023

<p>Background and Objective: &nbsp;Long-chain polyunsaturated fatty acids (LCPUFA) play an important role in the regulation of fat metabolism in the placenta and fetus. Changes in placental function in pre-eclampsia affect the transport of fatty acids and affect fetal nutrition. The aim of the study was to compare LCPUFA levels in blood, placenta and cord blood of pregnant women with or without pre-eclampsia.</p>
<p>Methods: &nbsp;The blood, placenta and umbilical cord blood of pregnant women (n = 30 each) who were normotensive and with pre-eclampsia were collected. The levels of fatty acids in maternal blood, placenta and umbilical cord blood were determined by the quartz capillary gas chromatography technique.</p>
<p>Results: &nbsp;The average age of normal pregnant women was 27.0&plusmn;4.5 years and that of pre-eclampsia pregnant women was 30&plusmn;4.0 years (P &gt; 0.05). The levels of total fatty acids, arachidonic acid (AA) and docosahexaenoic acid (DHA) were higher in pregnant women with pre-eclampsia than in normal women. The level of linoleic acid in cord blood and placenta was significantly higher in pre-eclampsia group than in the normal pregnant women while linoleic acid content in maternal blood being lower in pre-eclampsia group compared to the normal maternal group.</p>
<p>Conclusion: &nbsp;The changes of LCPUFA in blood, placenta and umbilical blood of pre-eclampsia may be related to the changes of LCPUFA in placenta. These changes may be involved in the pathophysiological process of pre-eclampsia. Maternal supplement of LCPUFA, such as DHA, in early gestation may be helpful in improving morbidity associated with maternal eclampsia.</p>
Strategies Proposed by Students and Pharmacists for Virtual Experiential Patient Care Practicums
Authors: Leung Rebecca , Hefford Hayley , Chew Caitlin , Yuen Jamie 
Published: November 2023

Background: The University of British Columbia (UBC) Pharmacists Clinic (the Clinic) is a pharmacist-led patient care clinic serving as a practice site for experiential education in a team-based primary care practice. Given the unprecedented circumstances surrounding COVID-19, pharmacy practice sites have transitioned some of their experiential education activities to a virtual format. Currently, there is limited literature on developing best teaching practices which are conducive to students’ success in a virtual environment.
Objective: To determine the factors that enable successful development of a virtual patient care practicum experience at a university clinic from the perspectives of student pharmacists and practice educators.
Methods: A qualitative research methodology was used to gain the perspectives of student pharmacists and practice educators. Separate focus group interviews were conducted using a semi-structured approach and consisted of questions aimed at gathering insight into participant perspectives on virtual practicums. The focus group sessions were audio recorded with participant consent and transcribed. A thematic analysis was conducted to analyze the data.
Results: Three pharmacist practice educators and three student pharmacists participated in their respective focus groups. A thematic analysis was used to analyze the data. Six major themes emerged: (1) technology optimization, (2) patient care related activities, (3) student-practice educator relationship, (4) student skill development, (5) student support, and (6) in-person vs virtual practicum preferences. Proposed strategies to mitigate the limitations of virtual practicums included setting communication guidelines, arranging enriching learning opportunities, and having reliable internet connection.
Conclusion: The participants in this study provided insight on factors to support successful development and delivery of a virtual patient care practicum. The results from this study can be applied to other health disciplines and their approach to virtual practicums during and following the COVID-19 pandemic.
Sistem Informasi Perpustakaan Mudah Berbasis Web
Authors: Purnomo Hamron Sulistyo , Pungkasanti Prind Triajeng 
Published: November 2023

<p class="BasicParagraph">SMP Islam Sultan Agung 1 adalah sebuah lembaga pendidikan yang terletak di daerah yang strategis, dipusat kota semarang. Seiring berkembangnya teknologi serta meningkatnya kebutuhan serta semakin kompleksnya permasalahan yang dihadapi, membuat lembaga pendidikan ini membutuhkan aplikasi sistem informasi yang dapat membantu mempercepat penyelesaian pekerjaan.Tujuan dari tugas akhir yang penulis lakukan adalah terciptanya aplikasi sistem informasi perpustakaan pada SMP Islam Sultan Agung 1. Diharapkan dengan aplikasi sistem informasi perpustakaan<em> admin</em> unit kerja perpustakaan dapat mengelola data buku, data anggota, data transaksi peminjaman dan pengembalian buku buku perpustakaan dengan lebih baik. Metode yang digunakan untuk pembuatan tugas akhir ini adalah metode observasi, wawancara dan studi pustaka. Data yang digunakan adalah data data primer yang diperoleh dari petugas perpustakaan, siswa selaku pemustaka dan studi literasi. Berdasarkan analisa data yang dilakukan disimpulkan bahwa diperlukan aplikasi sistem informasi perpustakaan yang dapat untuk memasukkan data buku, data anggota, data transaksi peminjaman dan pengembalian, sehingga segala data akan tersimpan dalam <em>database</em>. Tersimpannya data dalam <em>database</em> akan memudahkan dalam pengelolaan dan pengolahan data.<strong></strong></p><p class="IsiAbstrakIndo"><em>Sultan Agung 1 Islamic Junior High School is an educational institution located in a strategic area, in the center of Semarang city. Along with the development of technology and the increasing needs and increasingly complex problems faced, this educational institution requires an information system application that can help to accelerate the completion of work. The aim of the study is to create library information system application at SMP Islam Sultan Agung 1. It is hoped that Librarians can manage the books data, members data, data on borrowing and returning books in the library well. This research method using observation, interviews and literature study. The primary data were collected by interviewing the librarian and students as the users, while the secondary data was collected by literature studies. Based on the the result study, It is concluded that a library information system application is needed to entry the books data, members data, data on borrowing and returning books in the library, so that all data will be stored in the database. Storing the data in the database will facilitate the management and the processing of data.</em></p><p class="BasicParagraph"> </p>
Analisis Kolaborasi Hubungan Karyawan Menggunakan Metode Social Network Analysis (Studi Kasus Dinas Kearsipan dan Perpustakaan Kabupaten Boyolali)
Authors: Kuncoro Wreda Agung , Sediyono Eko , Hartomo Kristoko Dwi 
Published: November 2023

<p>Good local government performance, especially related to the realization of good corporate governance, can be created if there is good communication between agencies, employees and compact collaboration to synergize policies that facilitate public services. To optimize government performance, one of which is the Boyolali District Archives and Library Service through collaborative relationships between employees so as to create intense two-way communication. This study aims to identify social networks related to collaboration between employees using the Social Network Analysis method and a total of 40 people as respondents, but only 32 people filled out the questionnaire data completely. The indicators used in viewing the research results are density values, degree centrality values, closeness centrality values, betweenness centrality values, and clique values. The results of the analysis obtained a network density level of 14.8% (considered weak because it is less than 50 percent). Employee number 21 has the highest degree centrality value and betweenness centrality value, then employee number 9 has the highest closeness centrality. This research concludes that there is a good collaborative relationship between the four departments in the Archives and Library Office of Boyolali Regency, namely the Operations department, the Service department, the Archives department, and the Librarian department. </p>
Analisis Proses Bisnis Sistem Informasi Akademik (Pengisian Kuesioner) Menggunakan Metode BPI
Authors: Razin Muhammad , Cahyo B.A.W.N. , As-Syafiq M.M. , Sumarsono S. 
Published: November 2023

Penelitian ini bertujuan untuk menganalisis proses bisnis yang terdapat pada sistem kuesioner yang digunakan di UIN Sunan Kalijaga serta mengetahui permasalahan dan kelemahan yang terdapat pada sistem tersebut. Maka dari itu diperlukan analisis untuk mengidentifikasi permasalahan yang terdapat pada proses bisnis menggunakan Root Cause Analysis (RCA) dengan cara memodelkan use case diagram, activity diagram, dan fishbone diagram. Dari hasil analisis permasalahan didapatkan 6 aktivitas yang bermasalah dan perlu adanya perbaikan pada proses bisnisnya dengan bantuan tools streamlining yang disediakan oleh Business Process Improvement (BPI). Hasil akhir dari penelitian ini adalah saran perbaikan terhadap sistem berupa error proofing, standardization, upgrading dan simplication.