bluuebunny/crossref_metadata_2025_split huggingface dataset:
EXPANSIN15 is involved in flower and fruit development in Arabidopsis
Authors: Bernal-Gallardo Judith Jazmin , González-Aguilera Karla L. , de Folter Stefan 
Published: January 2024

Abstract
Key message
EXPANSIN15 is involved in petal cell morphology and size, the fusion of the medial tissues in the gynoecium and expansion of fruit valve cells. It genetically interacts with SPATULA and FRUITFULL.

Abstract
Cell expansion is fundamental for the formation of plant tissues and organs, contributing to their final shape and size during development. To better understand this process in flower and fruit development, we have studied the EXPANSIN15 (EXPA15) gene, which showed expression in petals and in the gynoecium. By analyzing expa15 mutant alleles, we found that EXPA15 is involved in petal shape and size determination, by affecting cell morphology and number. EXPA15 also has a function in fruit size, by affecting cell size and number. Furthermore, EXPA15 promotes fusion of the medial tissues in the gynoecium. In addition, we observed genetic interactions with the transcription factors SPATULA (SPT) and FRUITFULL (FUL) in gynoecium medial tissue fusion, style and stigma development and fruit development in Arabidopsis. These findings contribute to the importance of EXPANSINS in floral and fruit development in Arabidopsis.
Fischdurchgängigkeit mittels innovativer Buhnen in kombinierten skalierten und ethoyhdraulischen 1:1-Modellversuchen am Beispiel des Wienflusses
Authors: Sindelar Christine , Lasinger Nora , Buchinger Matthias , Leutgöb Elena , Habersack Helmut 
Published: January 2024

ZusammenfassungDer Wienfluss ist im Stadtgebiet von Wien über weite Strecken ein künstliches Gerinne mit gepflasterter Sohle und monotonem Querprofil. Geringe Wassertiefen und hohe Geschwindigkeiten bei niedrigen Abflüssen sorgen dafür, dass der Wienfluss an vielen Stellen nicht fischpassierbar ist. In einem skalierten physikalischen 1:8-Modell wurde eine optimale Buhnenvariante durch Variation verschiedener Buhnenparameter entwickelt, die im 4 km langen Projektgebiet ab der Kennedybrücke die Fischdurchgängigkeit wiederherstellen kann. Die Lösungsvariante besteht aus wechselseitig angeordneten inklinanten Buhnen mit einer Höhe von 0,2 m, einer Länge von 4 m, einem Winkel von 70 Grad und einem Buhnenabstand von 6 m. Die Möglichkeiten des neuen BOKU-Wasserbaulabors wurden genutzt, um einen Abschnitt des Wienflusses samt den Buhnen im Naturmaßstab 1:1 aufzubauen. In ethohydraulischen Versuchen wurde überprüft, ob die Leitfischarten des Wienflusses – Aitel, Gründling und Schmerle – bei den Durchflüssen Q330 und MQ die Buhnenstrecke durchwandern können. Dieser Nachweis konnte für den Aitel und den Gründling erbracht werden. Die nacht- und dämmerungsaktiven Schmerlen konnten in der Nacht nicht beobachtet werden, konnten sich aber problemlos in der Buhnenstrecke aufhalten, ohne abzudriften. Naturähnliche 1:1-Versuche im BOKU-Wasserbaulabor ermöglichen es, das volle Spektrum an klein- und großskaligen Strukturen in turbulenten Strömungen abzubilden und durch die Verwendung von Donauwasser Wasserqualitätsprobleme auszuschließen, was für (etho-)hydraulische Fragestellungen einen entscheidenden Vorteil darstellt.
Comparisons of assessment pathways after abnormal mammography screening in Denmark, Norway, and Spain
Authors: Jørgensen Susanne Fogh , Sagstad Silje , Louro Javier , Román Marta , Castells Xavier , Hofvind Solveig , Njor Sisse 
Published: January 2024

Abstract
Purpose
To ensure high-quality screening programmes and effective utilization of resources, it is important to monitor how cancer detection is affected by different strategies performed at recall assessment. This study aimed to describe procedures performed at recall assessment and compare and evaluate the performance of the assessment in Denmark, Norway, and Spain in terms of screen-detected cancer (SDC) and interval cancer (IC) rates.

Methods
We included women aged 50–69 years from Denmark, Norway, and Spain, who were recalled for assessment after screening mammography, and recorded all procedures performed during six months after diagnosis, and the timing of the procedures. Women were followed for two years and screen-detected and interval cancer, and sensitivity of recall was calculated and compared.

Results
In total, data from 24,645 Danish, 30,050 Norwegian, and 41,809 Spanish women were included in the study. Most of the women had some assessment within 2 months in all three countries. SDC rates were higher in Denmark (0.57) and Norway (0.60) compared to Spain (0.38), as were the IC rates, i.e. 0.25 and 0.18 vs. 0.12, respectively. The sensitivity of the diagnostic follow-up was somewhat higher in Denmark (98.3%) and Norway (98.2%), compared to Spain (95.4%), but when excluding non-invasive assessment pathways, the sensitivities were comparable.

Conclusion
This comparison study showed variation in the assessment procedures used in the three countries as well as the SDC and IC rates and the sensitivity of recall.
Glass eels at the continental edge of Europe: revisiting catchment recruitment at the international River Minho/Miño
Authors: Stratoudakis Yorgos , Domingos Isabel , Antunes Carlos 
Published: January 2024

AbstractThe glass eel catch from the international River Minho, western Iberian Peninsula, forms the southernmost Atlantic series in the composite index outside the North Sea assessing European eel recruitment. Here, new experimental yield data from the lower estuary (1981–2022) and fishers´ daily records (1990–2022) were modelled to describe and compare seasonal and interannual trends. Seasonality matched river discharge climatology, possibly a more general feature in the southern range of the species distribution, with the difference between high and low season becoming less marked in recent periods of lower abundance. Glass eel yield showed a sharp decline during the 1980s, in line with the recruitment index outside the North Sea and with total Minho catch, but not with recent local estimates of catch per unit effort. This decline is corroborated by trends in fishers´ daily records, suggesting that the reduction in effort in the Minho was the consequence of a gradual adjustment to recruitment in the catchment mediated by progressively tighter local management measures. The inefficiency of fisheries regulatory measures to guarantee stock recovery alone calls for more comprehensive measures to reverse anthropogenic impacts on continental eel populations, but the task seems Herculean.
Antibacterial properties of marine algae incorporated polylactide acid membranes as an alternative to clinically applied different collagen membranes
Authors: Weitkamp Jan-Tobias , El Hajjami Soumaya , Acil Yahya , Spille Johannes , Sayin Selin , Okudan Emine Sükran , Saygili Eyüp Ilker , Veziroglu Salih , Flörke Christian , Behrendt Peter , Wiltfang Jörg , Aktas Oral Cenk , Gülses Aydin 
Published: January 2024

AbstractThe reconstruction of bony defects in the alveolar crest poses challenges in dental practice. Guided tissue regeneration (GTR) and guided bone regeneration (GBR) procedures utilize barriers to promote bone regeneration and prevent epithelial growth. This study focuses on evaluating the antibacterial properties of marine algae-polylactic acid (PLA) composite membranes compared to commercially available collagen membranes. Marine algae (Corallina elongata, Galaxaura oblongata, Cystoseira compressa, Saragassum vulgare, and Stypopodium schimperi) were processed into powders and blended with PLA to fabricate composite membranes. Cytocompatibility assays using human periodontal ligament fibroblasts (n = 3) were performed to evaluate biocompatibility. Antibacterial effects were assessed through colony-forming units (CFU) and scanning electron microscopy (SEM) analysis of bacterial colonization on the membranes. The cytocompatibility assays demonstrated suitable biocompatibility of all marine algae-PLA composite membranes with human periodontal ligament fibroblasts. Antibacterial assessment revealed that Sargassum vulgare-PLA membranes exhibited the highest resistance to bacterial colonization, followed by Galaxaura oblongata-PLA and Cystoseira compressa-PLA membranes. SEM analysis confirmed these findings and revealed smooth surface textures for the marine algae-PLA membranes compared to the fibrous and porous structures of collagen membranes. Marine algae-PLA composite membranes show promising antibacterial properties and cytocompatibility for guided bone and tissue regeneration applications. Sargassum vulgare-PLA membranes demonstrated the highest resistance against bacterial colonization. These findings suggest that marine algae-PLA composite membranes could serve as effective biomaterials for infection control and tissue regeneration. Further in vivo validation and investigation of biodegradation properties are necessary to explore their clinical potential.
Graphical Abstract
Economic effects of air quality on housing prices: evidence from Beijing, China
Authors: Cai Yuanyuan , Smit Martijn J. , Helbich Marco 
Published: January 2024

AbstractAir pollution is a major environmental urban issue, particularly in fast-growing cities in developing countries. Reducing air pollution is thus a challenge while evaluating the economic value of air quality is crucial for environmental policies made. However, few studies accurately estimate this value as they neglect the possible endogeneity issues, as well as the dynamic and heterogeneous effects of air pollution. Under the hedonic framework, we therefore assess the economic effect of fine particulate matter (PM2.5) on housing prices in Beijing, China. We construct a panel based on resale apartment transactions matched with average quarterly PM2.5 data between 2013 and 2019. To reduce the risk of an estimation bias, we apply an instrumental variable (IV) approach. Our results show that PM2.5 is negatively associated with housing prices. Households were willing to pay an extra 0.0852% per housing unit price for an average quarterly reduction in PM2.5 of 1 µg/m3. Furthermore, we argue that high-income dwellers tend to pay more for clean air. The negative effects of PM2.5 across regions are significant and different. Compared with that in the basic year 2013, the negative effect increases in the first 3 years and then decreases in the last 3 years. Our findings enhance our comprehension of the economic impact of air quality and make a valuable contribution to the nuanced understanding of willingness to pay for air quality, which is beneficial in assessing and optimizing environmental regulations.
Variational Structures Beyond Gradient Flows: a Macroscopic Fluctuation-Theory Perspective
Authors: Patterson Robert I. A. , Renger D. R. Michiel , Sharma Upanshu 
Published: January 2024

AbstractMacroscopic equations arising out of stochastic particle systems in detailed balance (called dissipative systems or gradient flows) have a natural variational structure, which can be derived from the large-deviation rate functional for the density of the particle system. While large deviations can be studied in considerable generality, these variational structures are often restricted to systems in detailed balance. Using insights from macroscopic fluctuation theory, in this work we aim to generalise this variational connection beyond dissipative systems by augmenting densities with fluxes, which encode non-dissipative effects. Our main contribution is an abstract theory, which for a given flux-density cost and a quasipotential, provides a decomposition into dissipative and non-dissipative components and a generalised orthogonality relation between them. We then apply this abstract theory to various stochastic particle systems—independent copies of jump processes, zero-range processes, chemical-reaction networks in complex balance and lattice-gas models—without assuming detailed balance. For macroscopic equations arising out of these particle systems, we derive new variational formulations that generalise the classical gradient-flow formulation.
Biogenic harmony of biocompatible silver nanoplatforms using chamomile extract and apigenin-7-glucoside for solid tumor therapy
Authors: Selim Adli A. , Abdelmonem Islam M. , Amin Mohamed A. , Essa Basma M. 
Published: January 2024

AbstractThis study focuses on tumor therapy using two biocompatible silver nanoplatforms of chamomile extract and its active ingredient apigenin-7-glucoside. Chamomile silver nanoparticles (Ch-AgNPs) and apigenin 7- glucoside silver nanoparticles (Ap-AgNPs) were synthesized and characterized using different analytical techniques. On a stable nanoplatform with spherical nanoparticles in a narrow size range, both Ch-AgNP and Ap-AgNP exhibit potent cytotoxic effects against two different cell lines (HepG2 and MCF7). The synthesized NPs were radiolabeled with 131I giving high radiochemical purity. Biodistribution studies in tumor-bearing Albino mice showed higher accumulation in tumor sites compared to normal muscle. In conclusion, after further preclinical studies, both chamomile silver nanoparticles (Ch-AgNPs) and apigenin-7-glucoside silver nanoparticles (Ap-AgNPs) can be used as potential drugs for tumor theranostics.
School Connectedness and Risk for Sexual Intercourse and Nonconsensual Sex in Adolescence
Authors: Miller Chelsea R. , Gajos Jamie M. , Cropsey Karen L. 
Published: January 2024

AbstractThe CDC reports that 30% of high school students have engaged in sexual intercourse. Evidence suggests biological, personal, peer, societal, and family variables affect when a child will initiate sex. The school environment plays an important role in a child’s development. Evidence suggests that greater attachment to the school community can modify sexual risk-taking activity in adolescents. Future of Families and Child Wellbeing Study (FFCWS) comprises a cohort of approximately 4,700 families of children born in the U.S. between 1998–2000, over-sampled for non-marital births in large U.S. cities. Adolescents (N = 3,444 of 4,663 eligible) completed the wave six teen survey at approximately age 15. School connectedness was self-reported with four items measuring inclusiveness, closeness, happiness, and safety felt by the adolescent in their school environment. Sexual intercourse and nonconsensual sex were self-reported by the adolescent. Hierarchical regression analyses were conducted examining sexual intercourse, nonconsensual sex, risk factors, and school connectedness. In this sample of adolescents (48% female, 49% Black, 25% Hispanic, ages 14–19), school connectedness appears to reduce boys’ risk of nonconsensual sex (OR = 0.29, p < 0.01), and reduce girls’ risk of engaging in sexual intercourse (OR = 0.55, p < 0.01). Findings suggest gender differences in the association between school connectedness and sexual practices in adolescents. School connectedness may confer protection for boys’ risk of nonconsensual sex, and for girls’ risk of engaging in sexual intercourse. Further exploration of the relationship between school connectedness may allow for recommendations into preventative measures for teenage sexual behaviors.
Performance-driven scheduling for malleable workloads
Authors: Almaaitah Njoud O. , Singh David E. , Özden Taylan , Carretero Jesus 
Published: January 2024

AbstractThe development of adaptive scheduling algorithms that take advantage of malleability has become a crucial area of research in many large-scale projects. Malleable workloads can improve the system’s performance but, at the same time, provide an extra dimension to the scheduling problem. This paper proposes an adaptive, performance-based job scheduling method that emphasizes the backfilling concept with malleability. The proposed method performs the malleability operations only when the estimated execution time of the involved applications is better than or equal to the execution time on the allocated resources without reconfiguration. The reconfiguration feasibility is determined by performance models considering the application scalability and reconfiguration overheads. Different policies for implementing malleability are presented, each targeting a specific workload in terms of job size and scalability. The comprehensive evaluation shows an improvement in the slowdown up to 49% compared to the non-adaptive baseline scheduling algorithm.
On Hostile and Oppressive Affective Technologies
Authors: Spurrett David 
Published: January 2024

Abstract4E approaches to affective technology tend to focus on how ‘users’ manage their situated affectivity, analogously to how they help themselves cognitively through epistemic actions or using artefacts and scaffolding. Here I focus on cases where the function of affective technology is to exploit or manipulate the agent engaging with it. My opening example is the cigarette, where technological refinements have harmfully transformed the affective process of consuming nicotine. I proceed to develop case studies of two very different but also harmful affective technologies. Casinos and electronic gambling machines deploy computationally intensive scaffolding to shape the onset and continuation of gambling episodes. High-heeled shoes affectively engineer wearers’ relationships to their own embodied capacities and are predominantly expected to be worn by women. I conclude with a discussion of the need for study of affective technology to focus other-directed applications, some of which will serve competing or antagonistic interests.
Putting the SWORD to the Test: Finding Workarounds with Process Mining
Authors: van der Waal Wouter , van de Weerd Inge , Beerepoot Iris , Lu Xixi , Kappen Teus , Haitjema Saskia , Reijers Hajo A. 
Published: January 2024

AbstractWorkarounds, or deviations from standardized operating procedures, can indicate discrepancies between theory and practice in work processes. Traditionally, observations and interviews have been used to identify workarounds, but these methods can be time-consuming and may not capture all workarounds. The paper presents the Semi-automated WORkaround Detection (SWORD) framework, which leverages event log traces to help process analysts identify workarounds. The framework is evaluated in a multiple-case study of two hospital departments. The results of the study indicate that with SWORD we were able to identify 11 unique workaround types, with limited knowledge about the actual processes. The framework thus supports the discovery of workarounds while minimizing the dependence on domain knowledge, which limits the time investment required by domain experts. The findings highlight the importance of leveraging technology to improve the detection of workarounds and to support process improvement efforts in organizations.
Construction and in vitro evaluation of pH-sensitive nanoparticles to reverse drug resistance of breast cancer stem cells
Authors: Li Weinan , Fu Yuhan , Sun Jialin , Gong Hexin , Yan Ru , Wang Yanhong 
Published: January 2024

AbstractBreast cancer is a major threat to safety and health of women. The breast cancer stem cells (BCSCs) have multi-drug resistance to chemotherapy drugs, which leads to chemotherapy failure. We proposed a strategy of delivery of tumor-killing drugs and a resistance reversal agent, to enhance inhibition of BCSCs. Here, schisandrin B (SchB)/AP NPs are constructed using acid-grafted-poly (β-amino ester) (ATRA-g-PBAE, AP) grafted polymer nanoparticle encapsulated SchB, with pH-sensitive release function. This drug delivery system has good pharmacological properties and can increase the SchB release with the decrease of pH. The NPs showed cytotoxic effects in reversing ATRA resistance to BCSCs. Lysosomal escape was achieved when the nanoparticles were taken up by BCSCs. In addition, we found that NPs may reverse MDR by inhibiting the expression of P-glycoprotein (P-gp) and affecting the energy supply of drug efflux. This study provides a nanodelivery therapy strategy that reverses BCSCs multidrug resistance (MDR) and demonstrates that it did so by interfering with cancer cell energy metabolism. Therefore, the co-delivery strategy of ATRA and SchB provides a new option for the treatment of breast cancer.
The Equity of Class Ability Grouping Practices in Australian Education: Findings from a Survey in Western Australia and Queensland
Authors: Johnston Olivia , Spooner-Lane Rebecca , Zhang Wei , Macqueen Suzanne , Spina Nerida 
Published: January 2024

AbstractGrouping students into separate classes according to their ‘ability’ is an inequitable practice that does not, overall, improve academic outcomes. Research has continued to show that class ability grouping widens the educational gap between students from disadvantaged and privileged backgrounds. PISA data analysis suggests that class ability grouping continues to be used in Australian schools, at least in Year 10. However, no research has characterized the existing class ability grouping practices being used in secondary schools from Years 7 to 9. The findings reported in this paper add quantitative evidence to the literature, showing that students are experiencing different class ability grouping practices according to their year group, subjects, and locations. An across-state survey about class ability grouping was conducted with respondents from 143 schools providing data about the schools’ class ability grouping practices. The findings reveal variations in how class grouping practices are used by schools in Australia that have been not captured in other research: Class ability grouping was activated differently in different schools, increased as students’ year levels increased, was most prevalent in Maths and English, and was used more extensively in Western Australia than in Queensland. The findings use descriptive statistics to show that students in Australia are experiencing different grouping practices, with discussion of how some practices are more inequitable than others. This raises questions about how the varied forms of class ability grouping that are being employed are contributing to educational inequalities in Australia and how future research can address this problem.
Teaching plant biology through “Plant senses”—a more engaging, holistic approach and introduction
Authors: Krtková Jana 
Published: January 2024

AbstractHigher education offers unique ways to provide students with knowledge of plant biology, as well as an engaging lens through which plants may be seen and appreciated. The tremendous volume of knowledge sometimes calls for introducing a different conceptual view to students who aim to become involved in plant research and related fields. It requires stepping back to consider the plant as a whole organism, connected to other organisms within an ecosystem and as a complex living form with its own plant-specific senses. Inspired by several bestselling books in this field, I launched a Plant Senses course. When using the Plant Senses tool to teach plant biology it is challenging to prevent students from over-interpreting and projecting animal features onto the plants, yet avoid an elitist zoocentric position that denies plant capacities we cannot observe with our animal perception. My course attempts to stimulate students to see the ecological importance of plants for much of life on this planet and to draw their attention to the economic value of plants to human societies. Here, I present the structure of the course and the topics covered. Further, I discuss the potential to spread this approach to other curricula and how these different fields may benefit from implementing such a course.