bluuebunny/crossref_metadata_2025_split huggingface dataset:
The impact of green entrepreneurial orientation on sustainability performance through the effects of green product and process innovation: The moderating role of ambidexterity
Authors: Coelho Arnaldo , Ferreira Jorge , Proença Catarina 
Published: December 2023

AbstractDrawing on the dynamic capability perspective, this study examines the impact of green entrepreneurial orientation (GEO) on sustainability performance through green innovation, considering the moderation of ambidexterity. Data were collected through a 26‐item questionnaire administered in two stages to key respondents from the operations and administrative/commercial departments, resulting in 369 valid responses from industrial small and medium‐sized enterprises (SMEs) in 13 Portuguese industrial districts. The findings reveal that GEO positively influences green processes and product innovation. This suggests that companies with this orientation prioritize environmental protection and business growth through green innovation. Consequently, these innovations enhance sustainability performance across the triple bottom line dimensions, highlighting the link between GEO and the mitigation of negative environmental impacts. The study argues that sustainability can drive competitiveness and stresses the need to balance exploration and exploitation to maximize the benefits of GEO on green innovation and sustainability.
Advances in β‐Diketocyclisation of Curcumin Derivatives and their Antitumor Activity
Authors: Dai Hailong , Zhang Si , Zheng Xing , Luo Zhongqin , Chen Hongfei , Yao Xu 
Published: December 2023

AbstractCurcumin, derived from the popular spice turmeric, is a pharmacologically active polyphenol. Curcumin's therapeutic activity has been extensively studied in recent decades, with reports implicating curcumin in many biological activities, particularly, its significant anticancer activity. However, its potential as an oral administration product is hampered by poor bioavailability, which is associated with a variety of factors, including low water solubility, poor intestinal permeability, instability, and degradation at alkaline pH. To improve its bioavailability, modifying β‐diketone curcumin with heterocycles, such as pyrazole, isoxazole and triazole is a powerful strategy. Derivatives are synthesized while maintaining the basic skeleton of curcumin. The β‐diketone cyclized curcumin derivatives are regulators of multiple molecular targets, which play vital roles in a variety of cellular pathways. In some literatures, structurally modified curcumin derivatives have been compared with curcumin, and the former has enhanced biological activity, improved water solubility and stability. Therefore, the scope of this review is to report the most recently synthesized heterocyclic derivatives and to classify them according to their chemical structures. Several of the most important and effective compounds are reviewed by introducing different active groups into the β‐diketone position to achieve better therapeutic efficacy and bioavailability.
Trustworthiness assessment as an inclusion criterion for systematic reviews—What is the impact on results?
Authors: Weeks Jo , Cuthbert Anna , Alfirevic Zarko 
Published: December 2023

AbstractBackgroundThere is increasing concern that a significant proportion of randomized controlled trials (RCTs) included in Cochrane reviews may not be trustworthy. Applying the Cochrane Pregnancy and Childbirth Trustworthiness Screening Tool (CPC‐TST) has already had a clinically important effect on several reviews published by the Cochrane Pregnancy and Childbirth Group.ObjectivesWe wanted to assess the impact of removing untrustworthy RCTs from already‐published Cochrane reviews on a defined clinical area (antenatal and postnatal nutritional interventions).MethodsWe applied the tool to 18 Cochrane reviews (374 RCTs). The tool had four domains: (i) is the research governance trustworthy; (ii) are the baseline characteristics trustworthy; (iii) is the study feasible; (iv) are the results plausible? When additional information was needed, authors were contacted using a standard template. At least two attempts were made to contact the authors. At the end of the evaluation process each study was classified as: (i) included (YES to all questions); (ii) excluded (retracted study); or (iii) awaiting classification (any NO to the questions).ResultsNinety‐three out of 374 included studies (25%) were reclassified as “excluded” or “awaiting classification.” The number of included RCTs was reduced in 14 out of 18 reviews. Six reviews (33%) were judged to require updating because of important differences in the Summary of Findings tables (direction and size of effects and/or GRADE ratings), conclusions, implication for practice, and/or implication for research.ConclusionsFormal assessment of trustworthiness, and inclusion only of studies that satisfy prespecified criteria for trustworthiness, affect conclusions in a relatively large number of Cochrane reviews, with potentially important clinical implications for practice and research.
Copper‐Catalyzed C−H (Phenylsulfonyl)difluoromethylation of Acrylamides: Scope, Mechanism, and Critical Role of Additives
Authors: Nobile Enzo , Doche Floriane , Castanheiro Thomas , Musaev Djamaladdin G. , Besset Tatiana 
Published: December 2023

AbstractHerein, we report the Cu‐complex catalyzed, native functional group‐assisted, and TFA/NMF additives promoted (phenylsulfonyl)difluoromethylation of vinylic C(sp2)−H bond of acrylamides. Using our in‐home designed reagent, this reaction enables the construction of the C(sp2)−CF2SO2Ph bond from simple C−H bond activation by copper catalysis under mild reaction conditions with total Z‐selectivity. The versatility of utilized fluorinated group was illustrated by its conversion into value‐added CF2 moieties as well as the remarkable =CHF residue. The performed experimental and computational mechanistic studies enabled to identify the true nature of active catalyst and substrate, as well as establish critical roles of TFA and NMF additives. In this reaction, the TFA acts as a promoter of the much‐needed CuII/CuII→CuIII/CuI disproportionation, while the NMF facilitates the following ligand exchange and C−C coupling processes. We ruled out the generation of radical intermediates and established the C−H activation to be irreversible and the rate‐determining step of the entire process.
Research progress on moisture resistance of gas sensors
Authors: Sun Xiaofeng , Shi Yu , Wang Huiyu , Shao Xiang , Yang Liu , Li Xue , Wang Minghao 
Published: December 2023

AbstractSensors used to detect explosive, flammable, toxic, and harmful gases are in focus of research. The gas sensor can be affected by many factors in the process of use, and among the many adverse elements affecting the function of the gas sensor, humidity is the most common. With the rapid development of gas sensors, the influence of humidity on gas sensors has been paid more and more attention. To reduce the impact of humidity, many methods have been proposed. In this review, the specific impact of humidity on the function of metal‐oxide semiconductors and solid electrolyte gas sensors is summarized. Practical techniques are proposed to reduce the effect of humidity on device performance, which is of great help in improving the detection efficiency and quality of gas sensors in high‐humidity environment. The information may be valuable for expanding the application field of gas sensors.
Presence and detection of endogenous steroids in the horse—A review
Authors: Viljanto Marjaana , Gray Bobby , Scarth James 
Published: December 2023

AbstractDetection of doping with steroids that are also endogenous in the horse can be challenging, and a variety of approaches to distinguish exogenous administration from their natural presence are employed. Knowledge of endogenous concentrations of various steroids in different genders of horses (intact male, castrated male and female) and factors that could naturally affect them is beneficial for establishing ways for detection of their use. The current internationally adopted approaches include concentration‐based thresholds in urine and plasma, steroid ratios in urine and targeting the administered intact steroid esters in plasma and hair. However, these have their limitations, and therefore, other strategies, such as additional biomarkers and steroid profiling based on longitudinal testing and multivariate analysis, have been investigated and could potentially improve detection of the use of endogenous steroids in horses. This paper aims to provide a comprehensive overview of the steroids (androgens, oestrogens and progestogens) that have been reported to be endogenous to horses in literature, their concentration ranges in different genders and factors potentially affecting them as well as current and possible future approaches to detect their use.
Causal relationship between aspirin consumption and heart failure: a Mendelian randomization study
Authors: Cai Wenyi , Fang Zhang , Tian Zhiqiang , Li Dianfu , Tang Kangting 
Published: December 2023

AbstractAimsThis study aimed to investigate the causal association of aspirin consumption with the risk of heart failure.MethodsOur study included a total of 218 208 individuals, with 23 397 cases of heart failure. Genetic summary data on the association between single‐nucleotide polymorphisms (SNPs) and aspirin consumption were obtained from a large‐scale genome‐wide association study involving 462 933 individuals, of which 61 702 people were taking aspirin. After the exclusion of critical confounding factors, we assessed the final and independent association between the aspirin consumption and the risk of heart failure using 3 two‐sample Mendelian randomization (MR) methods‐inverse variance weighted (IVW), weighted‐median, and MR‐Egger regression. Sensitivity analyses and directionality test were employed to further validate the stability of the results.ResultsAfter excluding the SNPs that exhibited associations with potential confounders and harmonizing the data, a total of 32 SNPs were finally selected for MR analysis from the initially identified 60 SNPs that displayed strong associations with the exposure. The results of the main method (IVW) showed a significant positive association between aspirin use and the occurrence of heart failure (OR [odds ratio]: 1.085; 95% CI [confidence interval]: 1.015–1.161; P = 0.017), although other methods did not showed statistically significant results (MR‐Egger, OR: 1.211, 95% CI: 0.842–1.21, P = 0.896; weighted‐median, OR: 1.087, 95% CI: 0.983–1.202, P = 0.105). Heterogeneity test, the MR‐Egger intercept, and the funnel plot did not reveal any evidence of heterogeneity (Cochran's Q statistic = 29.263; P = 0.556) or horizontal pleiotropy (intercept = 0.007; P = 0.319). The ‘leave‐one‐out’ analysis indicated that no individual SNP exerted a dominant influence on the main estimate. Directionality test confirmed the accuracy of the causal relationship between exposure and outcome direction in our data.ConclusionsOur results support a potential positive causal relationship between aspirin consumption and the occurrence of heart failure.
Synthesis and Applications of Trifluoromethylphosphines
Authors: Zhang Shouzhi , Fan Wu , Li Suhua 
Published: December 2023

AbstractTrifluoromethylphosphines (TFMPhos) represent a rare kind of phosphine with unique electronic properties that result in unusual reactivities, such as the ability to promote a reductive elimination step or as a trifluoromethylation reagent. This concept article summarizes current developments in methods for synthesizing this tertiary phosphine, as well as their practical applications.
Comprehensive analysis of Eleutherococcus senticosus (Rupr. & Maxim.) Maxim. fruits based on UPLC–MS/MS and GC–MS: A rapid qualitative analysis
Authors: Chang Yaodan , Jiang Yong , Chen Jingnan , Li Sen , Wang Yimeng , Chai Linlin , Ma Jingwen , Wang Zhibin 
Published: December 2023

AbstractEleutherococcus senticosus (Rupr. & Maxim.) Maxim. fruits (ESF), as a natural edible fruit, has long been popularized. However, few studies have conducted comprehensive chemical analyses of it. This study aimed to assess nonvolatile, volatile, and fatty oil components of ESF and to preliminarily explore the antioxidant activities. The qualitative and quantitative analyses of volatile and fatty oil components of ESF from 15 different regions were performed by the gas chromatography–mass spectrometry (GC–MS). Totally, 37 and 28 compounds were identified from volatile oil and fatty oil, respectively. The ultra‐high‐performance liquid chromatography–quadrupole time‐of‐flight mass spectrometry (UPLC–QTOF–MS/MS) was used to accurately detect 43 compounds of nonvolatile components. The volatile and fatty oil components and nonvolatile components of ESF were used as samples to determine the antioxidant activity of 2,2‐diphenyl‐1‐picrylhydrazyl (DPPH) in vitro. The components of ESF had antioxidant activity, and the nonvolatile components had stronger antioxidant activity. The results revealed that the proposed method, which is of great significance for the screening of new active ingredients, is valuable for the identification of pharmaceutical component and further development of food industry.
Extended orbital exenteration, epithetic restoration, and patient supply: A cross‐sectional study of a historic cohort
Authors: Ritschl Lucas M. , Schwarz Matthias , Klinger Franziska , Wolff Klaus‐Dietrich , Niu Minli , Weitz Jochen 
Published: December 2023

AbstractBackgroundThe aim of this study was to investigate the clinical course and to redefine an optimized algorithm for OE cases until epithetic restoration.MethodsIndication, defect type according to Kesting, reconstructive technique, incidence of postoperative complications and peri‐implantitis, patients' quality of life, timing of periorbital implant insertion, incidence of and interval to implant loss, and time until epithetic restoration were analyzed in 43 patients.ResultsA significant correlation was detected between wound dehiscence and defect type. Out of 24 patients, 7 were implanted secondarily with a median time interval of 399 days (270–2015) after OE. Eleven out of 83 placed implants were lost in 8 patients with a median time interval of 586 days (264–4485) after insertion. The majority of epithesis carriers had no or few restrictions in their quality of life.ConclusionsWe recommend our modified treatment algorithm to further improve and shorten the clinical course.
Peri‐weaning cholera toxin consumption suppresses chemically‐induced carcinogenesis in mice
Authors: Afaloniati Hara , Aindelis Georgios , Spyridopoulou Katerina , Lagou Maria K. , Tsingotjidou Anastasia , Chlichlia Katerina , Erdman Suzan E. , Poutahidis Theofilos , Angelopoulou Katerina 
Published: December 2023

AbstractGastrointestinal bacteria are known to have an impact on local and systemic immunity, and consequently either promote or suppress cancer development. Following the notion that perinatal bacterial exposure might confer immune system competency for life, we investigated whether early‐life administration of cholera‐toxin (CT), a protein exotoxin of the small intestine pathogenic bacterium Vibrio cholerae, may shape local and systemic immunity to impart a protective effect against tumor development in epithelia distantly located from the gut. For that, newborn mice were orally treated with low non‐pathogenic doses of CT and later challenged with the carcinogen 7,12‐dimethylbenzanthracene (DMBA), known to cause mainly mammary, but also skin, lung and stomach cancer. Our results revealed that CT suppressed the overall incidence and multiplicity of tumors, with varying efficiencies among cancer types, and promoted survival. Harvesting mouse tissues at an earlier time‐point (105 instead of 294 days), showed that CT does not prevent preneoplastic lesions per se but it rather hinders their evolution into tumors. CT pretreatment universally increased apoptosis in the cancer‐prone mammary, lung and nonglandular stomach, and altered the expression of several cancer‐related molecules. Moreover, CT had a long‐term effect on immune system cells and factors, the most prominent being the systemic neutrophil decrease. Finally, CT treatment significantly affected gut bacterial flora composition, leading among others to a major shift from Clostridia to Bacilli class abundance. Overall, these results support the notion that early‐life CT consumption is able to affect host's immune, microbiome and gene expression profiles toward the prevention of cancer.
Associations between the severity of menopausal symptoms and musculoskeletal pain in postmenopausal Portuguese women
Authors: Santo João Espírito , Lavilla‐Lerma María Leyre , del Carmen Carcelén‐Fraile María , de Loureiro Nuno Eduardo Marques , Brandão‐Loureiro Vânia , Alzar‐Teruel María , Ortiz‐Quesada Raúl 
Published: December 2023

AbstractObjectiveTo analyze the association of the severity of the menopausal symptoms with musculoskeletal pain in Portuguese postmenopausal women.MethodsA cross‐sectional, observational study was conducted on 167 women (63.85 ± 9.36 years). The Menopause Rating Scale was used to evaluate the menopausal symptoms severity, while the Nordic Musculoskeletal Questionnaire was employed to assess the localization of the musculoskeletal pain, and multi‐located pain was determined if two or more body regions were affected. Depression (Hospital Anxiety and Depression Scale), age, body mass index (BMI) and physical activity level were considered as potential confounders.ResultsA greater severity of the somato‐vegetative menopausal symptoms was related to the prevention from usual activities because of pain in the neck, shoulders, elbows, wrists/hands and knees (R2 of Nagelkerke = 0.064, 0.043, 0.074, 0.045 and 0.045, respectively). Associations were also observed between greater age and pain in the knees, ankles and feet (R2 of Nagelkerke = 0.036 and 0.034, respectively), and being physically inactive with upper back pain (R2 of Nagelkerke = 0.060). Higher depressive symptoms were linked to pain in the hip/thighs and knees (R2 of Nagelkerke = 0.067 and 0.085, respectively), as well as being physically inactive was related ton in the neck (R2 of Nagelkerke = 0.053). Only a greater BMI was related to multi‐located pain in the last 7 days (R2 of Nagelkerke = 0.041).ConclusionsThe findings of our study showed that, taking into account possible confounders, greater severity of the menopausal symptoms at a somatic‐vegetative level was associated with more anatomical regions with musculoskeletal pain.
Lactation failure following therapeutic steroid treatment in a mother with postpartum depression and spinal‐dural arteriovenous fistula: Case report and literature review
Authors: Das Nabagata , Dave Stuti , Dangaich Radha , Ganjekar Sundarnag , Guddanti Venkata Naga Pradeep , Hanumanthapura Ramalingaiah Arvinda , Thippeswamy Harish , Chandra Prabha S. 
Published: December 2023

SynopsisTherapeutic steroid use among lactating mothers may cause lactation failure. Animal studies have shown impairment in secretary activity of lactocytes by exogenous steroid treatment.
Sample selection in linear panel data models with heterogeneous coefficients
Authors: Carlson Alyssa , Joshi Riju 
Published: December 2023

AbstractWe propose a parametric estimation procedure for linear panel data models with sample selection and heterogeneous coefficients that are present in both outcome model and selection model. Our two‐step estimation procedure accounts for endogeneity from the selection process and endogeneity from correlation between the individual unobserved heterogeneity and the observed covariates using control function like methods. Conditional linear projections are used to establish a tractable approach that builds upon the original Heckman correction to sample selection. Monte Carlo simulations illustrate the finite sample properties of our estimator and demonstrate that our proposed estimator outperforms standard estimators. We apply the proposed approach to estimate gender differences in high‐stakes time‐constrained decisions using Elo ratings data from the World Chess Federation. When addressing both sources of endogeneity, we find a much larger gender skill gap and substantial differences across the genders in strategically selecting into time‐constrained matches.
Band gap, Jahn‐Teller deformation, octahedra rotation in transition metal perovskites LaTiO3
Authors: Pascale F. , Gueddida S. , Doll K. , Dovesi R. 
Published: December 2023

AbstractThe LaTiO perovskite (where Ti is in a d1 state) is investigated by using an all electron Gaussian basis and many functionals, ranging from pure GGA (PBE), to hybrids (full range, B3LYP and PBE0, and range separated, HSE06) to Hartree Fock. Recently, Varignon et al. (Phys. Rev. Res 1, 033131, 2019), showed that, when GGA+U or HSE06 are used, a metallic solution and fractional occupancy of the t subshell are obtained. Here, it is shown that when a full range hybrid functional is used, an integer occupancy is obtained, as suggested by the Jahn‐Teller theorem. When the exact exchange percentage varies from 0 to 100, the system is insulating when it exceeds 20. By reducing progressively the symmetry from cubic down to orthorhombic, the relative importance of the Jahn‐Teller deformation and of the rotation of the octahedra is explored.
A novel image processing procedure for the quantitative evaluation of dental enamel prism arrangement
Authors: Hegedűs Máté , Kis Viktória K. , Rózsa Noémi , Kovács Zsolt 
Published: December 2023

AbstractEnamel prism is the main microstructural unit of mammalian enamel which composed of hundreds of bioapatite nanocrystals. Prism structure plays a key role in the excellent mechanical performance of dental enamel during millions of chewing cycles without significant remodeling. Thus, quantitative understanding of prism architecture is of utmost importance for biomechanical materials design. To characterize enamel prism orientation quantitatively, a novel image processing method has been developed. Our method is based on scanning electron microscopy images of etched enamel surface and consists of an ellipse fitting procedure, which provides a numerical approximation of prism shape and orientation in the studied cross section. The obtained analytical data allow to construct color coded orientation maps, which provide quick and useful insight into the microstructure of enamel. Besides striking visualization, orientation maps allow to extract and plot the rich information on the azimuthal and inclination angles of the prisms as function of location. Numerical data on prism arrangement can be analyzed using statistical tools over large areas, which paves the way towards quantifying comparative investigation of prism arrangement either in dentistry research or evolution biology. The application of the method is demonstrated for a distal–mesial cross‐section of sound human tooth enamel.Highlights
Scanning electron microscopy images of etched enamel surface are analyzed using ellipse fitting.
Geometrical parameters of the fitted ellipses provide numerical data of thousands of prisms.
Prism arrangement is visualized on color coded orientation maps and analyzed using statistical tools.