bluuebunny/crossref_metadata_2025_split huggingface dataset:
GH136‐encoding gene (perB) is involved in gut colonization and persistence by Bifidobacterium bifidumPRL2010
Authors: Rizzo Sonia Mirjam , Vergna Laura Maria , Alessandri Giulia , Lee Ciaran , Fontana Federico , Lugli Gabriele Andrea , Carnevali Luca , Bianchi Massimiliano G. , Barbetti Margherita , Taurino Giuseppe , Sgoifo Andrea , Bussolati Ovidio , Turroni Francesca , van Sinderen Douwe , Ventura Marco 
Published: January 2024

AbstractBifidobacteria are commensal microorganisms that typically inhabit the mammalian gut, including that of humans. As they may be vertically transmitted, they commonly colonize the human intestine from the very first day following birth and may persist until adulthood and old age, although generally at a reduced relative abundance and prevalence compared to infancy. The ability of bifidobacteria to persist in the human intestinal environment has been attributed to genes involved in adhesion to epithelial cells and the encoding of complex carbohydrate‐degrading enzymes. Recently, a putative mucin‐degrading glycosyl hydrolase belonging to the GH136 family and encoded by the perB gene has been implicated in gut persistence of certain bifidobacterial strains. In the current study, to better characterize the function of this gene, a comparative genomic analysis was performed, revealing the presence of perB homologues in just eight bifidobacterial species known to colonize the human gut, including Bifidobacterium bifidum and Bifidobacterium longum subsp. longum strains, or in non‐human primates. Mucin‐mediated growth and adhesion to human intestinal cells, in addition to a rodent model colonization assay, were performed using B. bifidum PRL2010 as a perB prototype and its isogenic perB‐insertion mutant. These results demonstrate that perB inactivation reduces the ability of B. bifidum PRL2010 to grow on and adhere to mucin, as well as to persist in the rodent gut niche. These results corroborate the notion that the perB gene is one of the genetic determinants involved in the persistence of B. bifidum PRL2010 in the human gut.
Media abnormal tone and cross section of stock returns: Evidence from China
Authors: Yan Lu , Ma Yong , Li Changshuai , Tang Guohao 
Published: January 2024

AbstractThis paper introduces an innovative methodology for extracting information from textual data to explain cross‐sectional stock returns, addressing limitations of conventional media tone measures. We find firms exhibiting higher media abnormal tone yield lower future returns in the Chinese market, even when controlling for common risk factors. This effect is more pronounced among firms with low investment, low profitability, and high short‐term reversal. We also find the negative premium generated by media abnormal tone results from mispricing, highlighting investor overreaction despite media's role in disseminating concurrent firm information. Furthermore, the tendency for media outlets to follow suit exacerbates investor overreaction.
Incidence and predictors of metabolic syndrome onset in individuals with bipolar disorders: A longitudinal study from the FACE‐BD cohort
Authors: Godin O. , Olié E. , Fond G. , Aouizerate B. , Aubin V. , Bellivier F. , Belzeaux R. , Courtet P. , Dubertret C. , Haffen E. , Lefrere A. , Llorca P. M. , Polosan M. , Roux P. , Samalin L. , Schwan R. ,   the FondaMental Academic Centers of Expertise in Bipolar Disorders (FACE‐BD) Collaborators, Leboyer M. , Etain B. 
Published: January 2024

AbstractIntroductionMetabolic syndrome (MetS) is a cluster of components including abdominal obesity, hyperglycemia, hypertension, and dyslipidemia. MetS is highly prevalent in individuals with bipolar disorders (BD) with an estimated global rate of 32.6%. Longitudinal data on incident MetS in BD are scarce and based on small sample size. The objectives of this study were to estimate the incidence of MetS in a large longitudinal cohort of 1521 individuals with BD and to identify clinical and biological predictors of incident MetS.MethodsParticipants were recruited from the FondaMental Advanced Center of Expertise for Bipolar Disorder (FACE‐BD) cohort and followed‐up for 3 years. MetS was defined according to the International Diabetes Federation criteria. Individuals without MetS at baseline but with MetS during follow‐up were considered as having incident MetS. A logistic regression model was performed to estimate the adjusted odds ratio and its corresponding 95% confidence interval (CI) for an association between each factor and incident MetS during follow‐up. We applied inverse probability‐of‐censoring weighting method to minimize selection bias due to loss during follow‐up.ResultsAmong individuals without MetS at baseline (n = 1521), 19.3% developed MetS during follow‐up. Multivariable analyses showed that incident MetS during follow‐up was significantly associated with male sex (OR = 2.2, 95% CI = 1.7–3.0, p < 0.0001), older age (OR = 2.14, 95% CI = 1.40–3.25, p = 0.0004), presence of a mood recurrence during follow‐up (OR = 1.91, 95% CI = 1.22–3.00, p = 0.0049), prolonged exposure to second‐generation antipsychotics (OR = 1.56, 95% CI = 0.99, 2.45, p = 0.0534), smoking status at baseline (OR = 1.30, 95% CI = 1.00–1.68), lifetime alcohol use disorders (OR = 1.33, 95% CI = 0.98–1.79), and baseline sleep disturbances (OR = 1.04, 95% CI = 1.00–1.08), independently of the associations observed for baseline MetS components.ConclusionWe observed a high incidence of MetS during a 3 years follow‐up (19.3%) in individuals with BD. Identification of predictive factors should help the development of early interventions to prevent or treat early MetS.
Accountable to whom? Relational accountability in social research
Authors: Ali Arshad I. , Talbert Rachel L. 
Published: January 2024

AbstractThis paper explores research in the always already colonized spaces of academia with people in what is now the United States. In research projects, Wilson (2008) reminds us to begin with community relationships. Through ethnographic work, we trouble the idea of beginning research via local powerbrokers, who may privilege particular narratives and individuals. We offer reflections reconsidering power dynamics in community‐based ethnographic studies suggesting ways to think about who research relationships are built with.
Impossible arrangements: The extreme challenge of child care for low‐income mothers
Authors: Freeman Amanda 
Published: January 2024

AbstractArranging safe and secure child care is necessary for parents of dependent children to maintain their participation in the labor force. This article uncovered the extreme version of work–childcare conflict faced by low‐income mothers. The constant, underlying threat of the loss of income and unsafe conditions for children influences child care and work, hindering their ability to move out of poverty even when employed. This qualitative study uses interview and focus group data collected from low‐income mothers in Colorado, Georgia, and Massachusetts from 2009 to 2020 to explore the obstacles as well as the strategies for finding and keeping child care. The data are the mother's voices as they describe their experiences negotiating care arrangements while working or looking for work. Factors that contributed to this extreme version of work–childcare conflict included: difficult conditions at work and mixed experience relying on care from family and friends. Also uncovered were problems affording paid care and utilizing public vouchers, which may undermine assistance programs. Child care from schools, family, and public programs were greatly diminished during the Covid‐19 pandemic, further exacerbating work–childcare conflict for low‐income mothers. Policy implications and the effects of the pandemic on childcare arrangements were also considered.
Israeli democracy threatened under right‐wing extremists: A “native anthropologist's” perspective from 2023
Authors: Shokeid Moshe 
Published: January 2024

AbstractThis narrative offers a personal and impressionistic account of a few major historical transformations of Israeli society seen through the lens of ethnographic observation. Anthropologists are trained to observe and analyze the “other”, whether individuals or groups, situated within the limited borders of space and time without judging their subjects' moral conduct in terms of their own ethical norms. That prescriptive guideline has been called into question in Geertz's iconic account of revisiting his old fields in Indonesia and Morocco, claiming that it was not only the ethnographer’s field sites that had changed but also the ethnographer himself and the discipline of anthropology. Geertz, one leading voice of anthropology, nevertheless adhered to “normative” ethnographic reporting. The present account is informed by the author's decades of ethnographic research, including, at a few critical moments, observations on the complex Israeli national saga. But—unlike my earlier ethnographic reports—the following captures the perspective and interpretations of the anthropologist as informant, that is, taking the role of an engaged Israeli. Note also that my political‐ideological orientation is considered as on the left of Israeli politics.
Peer support and mobile health for perinatal mental health: A scoping review
Authors: Liblub Sudjit , Pringle Kirsty , McLaughlin Karen , Cummins Allison 
Published: January 2024

AbstractBackgroundUp to one in five women experience perinatal depression and/or anxiety with profound negative consequences for mothers and families. Peer support interventions have the potential to effectively prevent perinatal mental health conditions. Meanwhile, mobile health has gained popularity and plays a significant role in enhancing maternal health services. However, little is known about the availability of mobile health combined with peer support for supporting perinatal mental health. This scoping review aimed to map the relevant literature and gain insights into the available evidence on mobile health and peer support for perinatal mental health, to identify gaps and inform opportunities for future research.MethodsA scoping review of the literature was conducted. The search strategy included five databases: CIANHL, Scopus, PsycInfo, PubMed, and ScienceDirect for the period from 2007 to 2022.ResultsEight studies met the inclusion criteria, including features of online support strategies, effectiveness, and attitudes of women about peer support with mobile health. The results showed decreased depressive scores and provided a positive experience for women. Strong satisfaction with accessibility and flexibility of mobile health was found when combined with the peer support features. Additional emotional support tools (e.g., mindfulness‐based activities) were likely to be acceptable to women and beneficial to mobile health.ConclusionsUnderstanding the context of peer support and mobile health informs the potential to support perinatal mental health. Further research in this growing area is needed to test the effectiveness of peer support in combination with mobile health intervention for supporting perinatal mental health.
Native forest and proximity to humans are stronger drivers of Brazilian cottontail habitat use than invasive European hare
Authors: Pasqualotto Nielson , Bailey Larissa L. , Chiarello Adriano G. 
Published: January 2024

AbstractHuman activities and biological invasions have caused unprecedented biodiversity loss over the past 500 years. Proximity to humans drives the spatial distribution of species toward less disturbed habitats. Invasive species can competitively exclude native species, but species may coexist due to different habitat preferences. Here, we investigated how proximity to farms and the presence of the non‐native European hare (Lepus europaeus) influence the habitat use by the Brazilian cottontail (Sylvilagus minensis) in southeastern Brazil. We found that the probability of cottontail site use increased with native forest cover and decreased with farmhouse proximity, ranging from 0.05 (SE = 0.02) at sites close to farmhouses (≅900 m) with no native forest to 0.70 (SE = 0.15) at sites far from farmhouses (≅2500 m) dominated by native forest. Higher risk of harassment and predation by free‐roaming dogs and cats may explain the negative effect of farmhouse proximity on cottontail habitat use. We found little evidence for competitive exclusion by the European hare. Instead, our results suggest that the two species spatially segregate due to different habitat preferences. While the European hare more likely uses farmland in its native and non‐native range, our results suggest that the Brazilian cottontail is a forest dweller. Although we found only weak evidence of competitive exclusion, we advise caution because invasive species may delay the onset of detrimental effects due to initial low population densities in newly invaded areas as is the case of the European hare in southeastern Brazil.Abstract in Portuguese is available with online material.
Baicalin alleviates oxygen–glucose deprivation/reoxygenation‐induced SK‐N‐SH cell injury via the regulation of miR‐556‐3p/ACSL4 pathway
Authors: Dai Weiwei , Yue Chunjing , Zhang Xiancai , Jia Yalian , Han Zongqi , Du Jingxia , Song Xiaohua 
Published: January 2024

AbstractBaicalin (BCL) has been found to have neuroprotective effects in ischemic stroke (IS), but its underlying molecular mechanisms are unknown. SK‐N‐SH cells were treated with BCL and then induced by oxygen–glucose deprivation/reoxygenation (OGD/R). Cell proliferation, apoptosis, inflammation, and ferroptosis were detected. Protein levels were examined by western blot. The expression levels of microRNA (miR)‐556‐3p and ACSL4 were tested via quantitative real‐time PCR. MiR‐556‐3p and Acyl‐CoA synthetase long‐chain family member 4 (ACSL4) interaction was confirmed via dual‐luciferase reporter assay and RNA pull‐down assay. Middle cerebral artery occlusion (MCAO) mice model was constructed to assess the role of BCL on brain injury in vivo. Our study showed that BCL treatment alleviated OGD/R‐induced SK‐N‐SH cell apoptosis, inflammation and ferroptosis. MiR‐556‐3p was decreased in OGD/R‐induced SK‐N‐SH cells, and BCL treatment enhanced its expression. MiR‐556‐3p could target ACSL4, and its overexpression relieved OGD/R‐induced SK‐N‐SH cell injury by targeting ACSL4. Besides, miR‐556‐3p inhibitor or ACSL4 overexpression reversed the inhibitory effect of BCL on OGD/R‐induced SK‐N‐SH cell injury. In vivo, BCL alleviated brain injury in MCAO mice through miR‐556‐3p/ACSL4 axis. In conclusion, BCL alleviated OGD/R‐induced SK‐N‐SH cell injury and relieved brain injury in MCAO mice by regulating miR‐556‐3p/ACSL4 axis.
Design, antitumor, and anti‐Ras activity of propynyl‐substituted harmine bases
Authors: Fang Yongsheng , Qi Jinchai , Fan Xiaoxiao , Wang Jiahui , Wang Hao , Liu Yonggang 
Published: January 2024

AbstractModifications at the harmine (HAM) 9‐N position demonstrated effective antitumor activity in previous studies. However, the difficult preparation, low yield and poor stability of derivatives limited their applications. A partial activity priming was carried out by converting the 9‐position substituted propargyl group of HAM to propynyl group. Molecular docking simulations of compound 9i with DYRK1A kinase showed that it was able to embed itself into the active pocket of the DYRK1A protein and formed hydrogen bonds with multiple active amino acid residues at a low binding energy. The results of molecular dynamics simulations showed that the RMSD (root mean square deviation) fluctuations of the complex were more gentle, and the trends of the changes in Rg (radius of gyration) and SASA (solvent accessible surface area) were lower, indicating that the DYRK1A protein was less disturbed and the structure of the complex was more compact and stable. The cytotoxicity assay indicated that compound 9i displayed good antiproliferative activity against human cancer cells MGC‐803, HepG2, and PANC‐1. In addition, 9i was able to reduce the ratio of polynomials induced by the Ras overexpression model of Caenorhabditis elegans, which showed anti‐Ras activity, and the RT‐qPCR results suggested that its anti‐Ras ability was not achieved by directly inhibiting the expression of the let‐60/Ras genes, and that 9i was able to upregulate the expression of SOD‐3 activation of oxidative stress, which means that it may be useful as a pro‐oxidant for the treatment of cancers caused by Ras over‐activation.
Infectious keratitis following corneal transplantation: A long‐term cohort study
Authors: Ittah‐Cohen Ian , Knoeri M. Juliette , Bourcier Tristan , Merabet Lilia , Bouheraoua Nacim , Borderie Vincent M. 
Published: January 2024

AbstractBackgroundTo assess the long‐term incidence and risk factors for post‐keratoplasty infectious keratitis (IK), associated ocular pathogens, and antibiotic resistance profiles.MethodsCohort study including 2553 consecutive penetrating, endothelial, and anterior lamellar keratoplasties performed between 1992 and 2020. Medical and microbiological records of patients clinically diagnosed with IK were retrospectively reviewed. Main outcome measures: cumulative incidence of IK, infectious agent species, and antibiotics resistance profiles.ResultsThe average follow‐up time after transplantation was 112 ± 96 months. Eighty‐nine IK episodes were recorded; microbiological tests were positive in 55/89 (62%). The cumulated incidence of postoperative IK was 5.50%/10.25% at 10/20 years. The occurrence of at least one episode of IK after transplantation was associated with lower graft survival in the long term (p < 0.0001). Rejection risk (adjusted Hazard Ratio, 2.29) and postoperative epithelial complications (HR, 3.44) were significantly and independently associated with a higher incidence of postoperative IK. Infectious agents included 41 bacteria, 10 HSV, 6 fungi, and 1 Acanthamoeba. The rate of antibiotic resistance was 0% for vancomycin, 13% for fluoroquinolones, 20% for rifamycin, 59% for aminoglycosides, and 73% for ticarcillin. In 41% of cases, patients were under prophylactic topical antibiotics before the infectious episode. Topical antibiotics were significantly associated with increased resistance to penicillin, carbapenems, and aminoglycosides.ConclusionIK (mainly bacterial) is a frequent complication of corneal transplantation in the long term. Vancomycin and fluoroquinolones can be considered as first‐line treatments. Prolonged postoperative antibiotic preventive treatment is not advisable as it may increase antibiotic resistance.
Visual, perceptual functions, and functional vision in children with unilateral cerebral palsy compared to children with neurotypical development
Authors: Crotti Monica , Ortibus Els , Mailleux Lisa , Decraene Lisa , Kleeren Lize , Itzhak Nofar Ben 
Published: January 2024

AbstractAimTo investigate visual (perceptual) function and functional vision in children with unilateral cerebral palsy (CP) and children with neurotypical development (NTD).MethodFifty children with unilateral CP (mean age 11 years 11 months, SD 2 years 10 months, range 7–15 years; 27 males; 26 left‐sided unilateral CP; Manual Ability Classification System [MACS] levels: I, 27; II, 16; III, 7) and 50 age‐ and sex‐matched children with NTD participated in a cross‐sectional study. Visual acuity, stereoacuity, and visual–perceptual functions were measured with standardized clinical tests. Functional vision was assessed in children with unilateral CP with the Flemish cerebral visual impairment questionnaire (FCVIQ). Group differences were investigated with Mann–Whitney U tests, Kruskal–Wallis tests, and the relative effect sizes r, η2 respectively. Correlations between visual assessments and the FCVIQ were investigated with Spearman's rank correlations.ResultsThe total group of children with unilateral CP showed reduced visual acuity compared with children with NTD (p = 0.02, r = 0.23). Only children with left‐sided unilateral CP scored lower than those with NTD on stereoacuity (p < 0.01, r = 0.36). Children with right/left‐sided unilateral CP scored significantly lower than those with NTD on visual–perceptual functions (p = 0.001–0.02), with large effect sizes on visuomotor integration and visual closure (both r = 0.57). Children with unilateral CP classified in MACS level III showed significantly lower scores on visual–perceptual assessments than children classified in MACS level I. Stereoacuity and visual–perceptual functions negatively correlated with the FCVIQ, with the highest association with visual (dis)interest and anxiety‐related behaviours.InterpretationMulti‐level visual profiling is warranted in the clinical intake of children with unilateral CP to detect visual impairments that further compromise their level of functioning.
Left atrial strain in adults after the arterial switch operation for transposition of the great arteries
Authors: Buendía‐Fuentes Francisco , Lozano‐Edo Silvia , Jover‐Pastor Pablo , Sánchez‐Martínez José C. , Martínez‐Sole Julia , Rodríguez‐Serrano María , Aguero Jaume , Arnau‐Vives Miguel A. , Osa‐Sáez Ana , Martínez‐Dolz Luis V. , Rueda Joaquín 
Published: January 2024

AbstractBackgroundNo study has focused on left atrial (LA) function assessed by echocardiography in adult patients with simple D‐TGA after arterial switch operation (ASO). We aimed to describe LA strain parameters in these patients.MethodsA prospective cohort study including 42 adult patients with simple D‐TGA after ASO and 33 aged‐matched controls. Phasic LA and LV global longitudinal strain (GLS) were obtained by transthoracic 2D‐speckle tracking echocardiography (STE). Volumetric and functional analysis of LA and LV were also evaluated by 2D and 3D analysis. A multivariable model was performed to investigate the variables that best differentiate patients with D‐TGA from healthy controls.ResultsLA strain parameters in D‐TGA patients were within the normal range described for healthy subjects. However, the three LA strain parameters (Reservoir, Conduit, and Contraction) were lower in patients (LASr: 31.13 ± 7.67 vs. 49.71 ± 8.38; LAS cd: ‐22.91 ± 5.69 vs. ‐34.55 ± 6.54; LASct: ‐8.14 ± 4.93 vs. ‐15.15 ± 6.07, p < .001 for all three comparisons). LA volumes were similar between patients and controls.LV‐GLS remained significantly lower in the D‐TGA group than in controls (‐17.29 ± 2.68 vs. ‐21.98 ± 1.84, p < .001).D‐TGA patients had evidence of worse LV ejection fraction measured by the Teichholz method (63.38 ± 8.23 vs. 69.28 ± 5.92, p = .001) and 3D analysis (57.97% ± 4.16 vs. 60.67 ± 3.39, p = .011) and diastolic dysfunction as compared to healthy controls.LV‐GLS and conduit LAS were the variables best differentiating patients with D‐TGA from healthy controls.ConclusionsLA strain is impaired in young adults with simple D‐TGA late after the ASO, probably in agreement with some degree of LV dysfunction previously described.