bluuebunny/crossref_metadata_2025_split huggingface dataset:
Edukasi Dan Pemeriksaan Boraks Dengan Bahan Alami Pada Jajanan Sekolah Menengah Atas
Authors: Mamay Mamay , Sulhan Muhammad Hadi , Ananda Riki 
Published: December 2023

Borax is a food additive which is prohibited from being used in food. Toxic effects of borax have been found to be harmful to human health. This compound is still widely abused in food samples. Detection of the presence of borax in the sample can be done with the use of natural materials. This community service aims to provide education that can increase the understanding of high school student participants about the dangers of borax and the identification with natural indicator such as turmeric (Curcuma longa), azalea flowers (Rhododendron concina) and red soka flower (Ixora auminta). The method used in the form of counseling and training on borax detection in samples with test paper from turmeric extract, azalea flower extract and red soka flower extract. In the implementation of the service, it was found that there was a change in understanding of borax and its toxic effects from 58% to 96% of science class students and 27% to 87% of social studies students. In the borax examination training, 92% of science student participants and 88% of social studies students were able to perform an examination with natural ingredients using test paper of turmeric extract, azalea flower, red soka flower. From the service process, it was found that, most of the participants knew about borax as a additive food which is prohibited from using and is harmful to health and can carry out a borax examination using natural indicators from turmeric, azalea flowers and red soka flowers.
Early in-hospital discontinuation of aspirin on the first post-procedural day after percutaneous coronary stent implantation in patients on direct oral anticoagulation
Authors: von Stein Philipp , Seitz Lukas , Wienemann Hendrik , Hohmann Christopher , Baar Till , Baldus Stephan , Halbach Marcel 
Published: December 2023

BackgroundPrevious trials investigating antithrombotic therapy with a direct oral anticoagulant (DOAC) and a P2Y12 inhibitor after percutaneous coronary intervention (PCI), termed dual therapy, allowed a short period of triple therapy including a DOAC, a P2Y12 inhibitor, and aspirin.AimsThis study aimed to determine whether discontinuation of aspirin on the first post-procedural day is safe or causes ischemic events.MethodsIschemic and bleeding events during hospitalization were investigated retrospectively in all patients treated with dual therapy (DOAC + P2Y12 inhibitor, designated as group 1) or triple therapy (DOAC + P2Y12 inhibitor+aspirin, designated as group 2) from day 1 after PCI at our center.ResultsOf 4,564 consecutive PCI procedures, 1,059 (23.2%) had an indication for OAC. Of these, 322 met the inclusion criteria for group 1 and 62 for group 2. Baseline characteristics, CHA2DS2-VASc and HAS-BLED scores showed no relevant differences between the two groups, and the main indication for DOAC therapy was atrial fibrillation in both groups. Approximately ¼ of patients were treated for acute coronary syndrome. The mean length of post-procedural hospitalization was 2.1 ± 2.5 and 2.2 ± 3.0 days in group 1 and 2, respectively (p = 0.305). One patient per group suffered a TIA (p = 0.297). There were no other ischemic events and no statistically significant differences in bleeding events. A subgroup analysis of cases hospitalized for ≥2 post-procedural days (group 1: 100 cases, mean 4.4 ± 3.4 days vs. group 2: 25 cases, mean 4.0 ± 4.1 days) confirmed these results.ConclusionThe initiation of dual therapy and thus discontinuation of aspirin on the first postprocedural day appears to be safe with respect to short-term ischemic events in a real-world population. Almost ¼ of patients undergoing PCI have an indication for OAC, highlighting the relevance of this issue.
Safety of corticosteroid therapy in sarcoidosis treatment
Authors: Di Marco Berardino Alessandro , Mei Federico , Zuccatosta Lina 
Published: December 2023

Introduction: Sarcoidosis is a multisystemic granulomatous disease of unknown origin and unpredictable cause, characterized by a dysregulated immune response. If histopathological hallmark is represented by the presence of non-caseating granulomas, clinical manifestations are variable and symptoms are not specific, and they depend on organs affected. Although thoracic involvement (lung and mediastinum) is the most common clinical manifestation, any organ can be virtually affected.Methods: This paper is structured as a narrative review. A literature search was performed in four electronic databases (Pubmed, Cochrane, Scopus, and Ovid Medline) and Google from inception until February 2023 for relevant studies, meta-analyses, and reviews on corticosteroids’ adverse events in sarcoidosis. English language only papers were included.Discussion: Although antimetabolites (such as Methotrexate) and immunosuppressant agents can be used as alternative therapy in refractory cases, traditionally systemic glucocorticoids represent the first choice for sarcoidosis treatment. However, their use is still debated, due to potential adverse effects, leading to a wide spectrum of complications particularly in patients who required long-term therapy. Hence, this article aims to provide a comprehensive updated review on the safety profile of glucocorticoid treatment in patients with sarcoidosis and their systemic effects.Conclusion: corticosteroids remain the first choice in Sarcoidosis, however, due to numerous side effects, dose and duration of treatment should be carefully adjusted and monitored by clinicians.
Association between serum total bilirubin and diabetic kidney disease in US diabetic patients
Authors: Lv Jian-Min , Shi Xiu-E , Ma Qiong , Chen Nan , Fu Mi , Liu Jian-Zheng , Fan Qiao-Rong 
Published: December 2023

BackgroundBilirubin has been widely reported to be a protective factor against diabetic kidney disease (DKD) in Asian populations. However, few large-sample analyses have been conducted in American populations. This study aimed to investigate the association between serum total bilirubin (STB) level and DKD in a US diabetic cohort.MethodsThis cross-sectional study enrolled participants from the National Health and Nutrition Examination Survey (NHANES) 2003–2018. Univariate and multivariate logistic regression analyses were performed to assess the association between STB level and DKD. Three models were conducted to control the potential confounding factors. Subgroup analysis was carried out for further validation.ResultsAmong the 5,355 participants, the median age [interquartile range (IQR)] was 62 [52–71] years; 2,836 (52.96%) were male, and 1,576 (29.43%) were diagnosed with DKD. In the entire cohort, no significant association between STB level and DKD was observed in any logistic regression models (p &gt; 0.05). Subgroup analysis revealed that, in U.S. diabetic males, STB levels &gt; 11.98 µmol/L were associated with a nearly 30% lower risk of DKD than STB levels ≤ 8.55 µmol/L. Additionally, a moderate STB level (8.56–11.98 μmol/L) was found associated with a nearly 25% lower risk of DKD in U.S. diabetic patients over 65 years old.ConclusionThe association of STB level with DKD may depict differences across diverse populations, among which the impact of race, sex, and age requires thorough consideration and relevant inferences should be interpreted cautiously.
Defining priorities for wildfire mitigation actions at the local scale: insights from a novel risk analysis method applied in Portugal
Authors: Benali Akli , Aparício Bruno A. , Gonçalves Ana , Oliveira Sandra 
Published: December 2023

IntroductionIn Portugal, the 2017 fire season was particularly extreme, leading to an unprecedented large number of fatalities, injured people, destruction of houses and infrastructures. These dramatic outcomes have contributed to raise awareness regarding the importance of ensuring the safety of people and assets from high intensity uncontrollable wildfires. It is crucial to identify the settlements at higher risk and the most suitable mitigation actions that can maximize the protection of people and assets.MethodsWe developed a simple methodology that combines exposure and vulnerability to estimate wildfire risk at the local level. Exposure was estimated using a fire spread simulation approach that was used to determine the probability of (i) a wildfire generating firebrands that could affect a settlement and (ii) a high intensity wildfire occurring adjacent to a settlement. Exposure was estimated using two fuel scenarios created to represent the current year of 2023 (short-term scenario) and 2030, assuming that no fuel management nor large fires occur in the meantime (medium-term worst-case scenario). Vulnerability was determined by the (i) Index of Total Dependence (IDT), and (ii) evacuation difficulty. Exposure and vulnerability metrics were normalized in percentiles, distributed into quadrants and combined to provide six levels of wildfire risk. For each vulnerability\exposure combination, we proposed a set of priority mitigation actions. The methodology was applied to three areas in Portugal where the risk estimates were analyzed and compared with the implementation rate of two risk mitigation programs already in place.ResultsResults showed that 8.7% of the settlements had “very high” wildfire risk and about 19.5% had “high” wildfire risk, potentially affecting 8,403 and 34,762 inhabitants, respectively. The spatial distribution of settlements at higher risk was very heterogeneous across the study areas and the total fraction ranged between 14% in Coimbra to 36% in Barlavento Algarvio. The overall implementation of mitigation programs in the study areas is very low, with only around 1% of the settlements in “very high” risk having any of the mitigation programs implemented. Conversely, our results also suggest that the implementation rate in settlements classified in lower risk classes is disproportionately high.DiscussionThe application of this risk analysis methodology can be used to assess the implementation status of mitigation actions, and contribute to tailor the actions that maximize the protection of people and assets according to the specific conditions found in each targeted area.
Cladribine and ocrelizumab induce differential miRNA profiles in peripheral blood mononucleated cells from relapsing–remitting multiple sclerosis patients
Authors: Arisi Ivan , Malimpensa Leonardo , Manzini Valeria , Brandi Rossella , Gosetti di Sturmeck Tommaso , D’Amelio Chiara , Crisafulli Sebastiano , Ferrazzano Gina , Belvisi Daniele , Malerba Francesca , Florio Rita , Pascale Esterina , Soreq Hermona , Salvetti Marco , Cattaneo Antonino , D’Onofrio Mara , Conte Antonella 
Published: December 2023

Background and objectivesMultiple sclerosis (MS) is a chronic, progressive neurological disease characterized by early-stage neuroinflammation, neurodegeneration, and demyelination that involves a spectrum of heterogeneous clinical manifestations in terms of disease course and response to therapy. Even though several disease-modifying therapies (DMTs) are available to prevent MS-related brain damage—acting on the peripheral immune system with an indirect effect on MS lesions—individualizing therapy according to disease characteristics and prognostic factors is still an unmet need. Given that deregulated miRNAs have been proposed as diagnostic tools in neurodegenerative/neuroinflammatory diseases such as MS, we aimed to explore miRNA profiles as potential classifiers of the relapsing–remitting MS (RRMS) patients’ prospects to gain a more effective DMT choice and achieve a preferential drug response.MethodsA total of 25 adult patients with RRMS were enrolled in a cohort study, according to the latest McDonald criteria before (pre-cladribine, pre-CLA; pre-ocrelizumab, pre-OCRE, time T0) and after high-efficacy DMTs, time T1, 6 months post-CLA (n = 10, 7 F and 3 M, age 39.0 ± 7.5) or post-OCRE (n = 15, 10 F and 5 M, age 40.5 ± 10.4) treatment. A total of 15 age- and sex-matched healthy control subjects (9 F and 6 M, age 36.3 ± 3.0) were also selected. By using Agilent microarrays, we analyzed miRNA profiles from peripheral blood mononuclear cells (PBMC). miRNA–target networks were obtained by miRTargetLink, and Pearson’s correlation served to estimate the association between miRNAs and outcome clinical features.ResultsFirst, the miRNA profiles of pre-CLA or pre-OCRE RRMS patients compared to healthy controls identified modulated miRNA patterns (40 and seven miRNAs, respectively). A direct comparison of the two pre-treatment groups at T0 and T1 revealed more pro-inflammatory patterns in the pre-CLA miRNA profiles. Moreover, both DMTs emerged as being capable of reverting some dysregulated miRNAs toward a protective phenotype. Both drug-dependent miRNA profiles and specific miRNAs, such as miR-199a-3p, miR-29b-3p, and miR-151a-3p, emerged as potentially involved in these drug-induced mechanisms. This enabled the selection of miRNAs correlated to clinical features and the related miRNA–mRNA network.DiscussionThese data support the hypothesis of specific deregulated miRNAs as putative biomarkers in RRMS patients’ stratification and DMT drug response.
Construction of a ferroptosis-based prognostic model for breast cancer helps to discriminate high/low risk groups and treatment priority
Authors: Zhang Liyong , Zhao Tingting , Wu Xiujuan , Tian Hao , Gao Pingping , Chen Qingqiu , Chen Ceshi , Zhang Yi , Wang Shushu , Qi Xiaowei , Sun Na 
Published: December 2023

IntroductionBreast cancer is a common malignant tumor associated with high morbidity and mortality. The role of ferroptosis, a regulated form of cell death, in breast cancer development and prognosis remains unclear. This study aims to investigate the relationship between ferroptosis-related genes and breast cancer and develop a prognostic model.MethodsRNA-seq expression datasets and clinical samples of breast cancer patients were obtained from public databases. Immunity- and drug resistance-related data were integrated. A preliminary screening was performed, resulting in the identification of 73 candidate ferroptosis factors. Univariate Cox regression analysis was conducted to select 12 genes, followed by LASSO Cox regression analysis to construct a prognostic risk prediction model consisting of 10 ferroptosis-related genes. The model was further characterized by immune cell infiltration. The expression levels of ferroptosis-related genes were validated in human breast cancer cell lines, and immunohistochemical (IHC) analysis was conducted on cancer specimens to assess ferroptosis-related protein expression.Results:The study identified 10 ferroptosis-related genes that were significantly associated with breast cancer prognosis. The constructed prognostic risk prediction model showed potential for predicting the prognostic value of these genes. In addition, the infiltration of immune cells was observed to be a characteristic of the model. The expression levels of ferroptosis-related genes were confirmed in human breast cancer cell lines, and IHC analysis provided evidence of ferroptosis-related protein expression in cancer specimens.DiscussionThis study provides a novel prognostic model for breast cancer, incorporating 10 ferroptosis-related genes. The model demonstrates the potential for predicting breast cancer prognosis and highlights the involvement of immune cell infiltration. The expression levels of ferroptosis-related genes and proteins further support the association between ferroptosis and breast cancer development.
Perceptions and experiences of community-based healthcare professionals in the state of Qatar having do not attempt resuscitation discussions during the COVID-19 pandemic
Authors: Fitzgerald Audrey , Fitzgerald Conor , Anderson Louise , Hussain Ammar Ali , Alinier Guillaume 
Published: December 2023

IntroductionThe values and attitudes of healthcare professionals influence their handling of “do-not-attempt-resuscitation” (DNAR) orders, as does that of the families they interact with. The aim of this study was to describe attitudes, perceptions, and practices among community-based medical practitioners towards discussing cardiopulmonary resuscitation and DNAR orders with patients and their relatives, and to investigate if the COVID-19 pandemic affected their practice in having these discussions.MethodsThis is a researcher-developed online survey-based study which aimed to recruit a convenience sample of respondents from a total population of 106 healthcare professionals working for the Mobile Healthcare Service (MHS), Hamad Medical Corporation Ambulance Service in the State of Qatar.Results33 family physicians, 38 nurses, and 20 paramedics (n = 91) responded to the questionnaire, of who around 40, 8, and 50%, respectively, had engaged in Do Not Attempt Resuscitation discussions during their work with MHS. 15% of physicians who had experience with Do Not Attempt Resuscitation discussions in Qatar felt that the family or patient were not open to having such discussions. 90% of paramedics thought that Do Not Attempt Resuscitation was a taboo topic for their patients in Qatar, and this view was shared by 75% of physicians and 50% of nurses. Per the responses, the COVID-19 pandemic had not affected the likelihood of most of the physicians or nurses (and 50% of the paramedics) identifying patients with whom having a Do Not Attempt Resuscitation discussion would be clinically appropriate.DiscussionOverall, for all three groups, the COVID-19 pandemic did not affect the likelihood of identifying patients with whom a Do Not Attempt Resuscitation discussion would be clinically appropriate. We found that the greatest barriers in having Do Not Attempt Resuscitation discussions were perceived to be the religious or cultural beliefs of the patient and/or their family, along with the factor of feeling the staff member did not know the patient or their family well enough. All three groups said they would be more likely to have a conversation about Do Not Attempt Resuscitation if barriers were addressed.
Therapeutic effects of curcumin on constipation-predominant irritable bowel syndrome is associated with modulating gut microbiota and neurotransmitters
Authors: Tu Xiaoting , Ren Hongyan , Bu Shurui 
Published: December 2023

IntroductionConstipation-predominant irritable bowel syndrome (IBS-C) is a functional bowel disease that affects 10–20% of the population worldwide. Curcumin (CUR) is widely used in traditional Chinese medicine to treat IBS, but its mechanism of action needs further investigation.MethodsIn this study, we used mosapride (MOS) as a positive control to evaluate the changes in gut microbiota in IBS-C rat models after treatment with CUR or MOS by analyzing 16S rDNA variation. In addition, we used enzyme immunoassay kits and immunohistochemical analysis to investigate whether CUR or MOS influenced serotonin (5-HT), substance P (SP), and vasoactive intestinal peptide (VIP) levels in the serum and colon of IBS-C rats.ResultsThe study showed that rats supplemented with CUR showed significantly increased fecal weight, fecal water content, small intestine transit rate and significantly decreased serum levels of 5-HT, VIP and SP compared to the IBS group (p &lt; 0.05). In addition, treatment with CUR changed the relative abundance of Blautia, Sutterella, Acetanaerobacterium and Ruminococcus2 in the gut microbiota.DiscussionThis study showed that the efficacy of CUR on IBS-C was possibly by modulating the microbiota and lowering the serum levels of HT, SP, and VIP.
Yield components affected by rice black-streaked dwarf virus disease in rice cultivars with different resistance levels
Authors: Sun Yue , Jing Dedao , Zhang Jiayuan , Du Linlin , Li Chenyang , Lan Ying , Lin Feng , Zhou Tong 
Published: December 2023

IntroductionRice black-streaked dwarf virus disease (RBSDVD) is one of the most destructive rice viral diseases, leading to severe yield losses in rice production. However, little is known about the yield-related components associated with the disease and no resistance cultivars have been successfully used in rice breeding.MethodsSeven rice cultivars were analyzed in this study, including six commercial rice varieties and a new line Zhongjian No. 201 (ZJ201) containing the resistance gene OsAP47. Resistance levels of these cultivars were evaluated by artificial inoculation and yield components were collected, including panicle length (PL), spikelets per panicle (SPP), ripened grains per panicle (RGPP), as well as panicles per square meter (PPSM) and 1000-grain weight (TGW). Seed setting rate (SSR) were calculated with the data of SPP and RGPP.Results and discussionThe results showed that ZJ201 displayed the highest resistance level and most of the commercial rice cultivars exhibited susceptible to RBSDVD. Yields of all the rice cultivars were significantly declined except ZJ201 and yield losses produced by RBSDVD were mainly due to the reduction of PL, SPP, RGPP, and TGW, suggesting that developments of these traits are associated with RBSDV infection. Resistant rice cultivar could reduce yield losses by maintaining normal development of these traits. Significant correlations were identified between resistance levels and the yield components except SSR and PPSM. The results provided useful clues for understanding the mechanisms of RBSDV invasion and its effect on rice production. ZJ201 was demonstrated as a resistance material that could be used in rice breeding.
Effect of neuromuscular electrical stimulation therapy using the StimaWELL 120MTRS system on erector spinae morphology in patients with chronic low back pain
Authors: Balthazard Loïck , Wolfe Daniel , Fortin Maryse 
Published: December 2023

ObjectiveChronic low-back pain (CLBP) is the leading cause of disability globally. CLBP is associated with a decrease in cross-sectional area (CSA) and an increase in fat infiltration (FI) of the lumbar paraspinal muscles, such as erector spinae (ES). Neuromuscular electrical stimulation (NMES) therapy showed promising outcomes in the treatment of CLBP, but its impact on ES morphology is unknown. Therefore, this study aimed to compare the effect of two NMES protocols on ES CSA and FI in a cohort of patients with CLBP.MethodsTwenty participants with CLBP (aged 18–60 years old) were randomized into the phasic (n = 11) or the combined (n = 9) protocol groups. They completed a 10-week (20 sessions) NMES therapy using the StimaWELL 120MTRS device. Magnetic resonance imaging (MRI) examinations were acquired at baseline and post-intervention to assess ES CSA and FI at all spinal levels (e.g., L1–L2 to L5–S1). Statistical analyses were conducted to assess the effect of the intervention on ES morphology irrespective of groups, and between groups.ResultsIrrespective of groups, participants showed a decrease in left ES CSA (p = 0.005) at L2–L3 and left ES FI at L5–S1 (p = 0.040). We also observed a greater decrease in ES FI in the combined protocol compared to the phasic protocol on the right side at L3–L4 (p = 0.029) and L4–L5 (p = 0.015). No other changes in ES CSA or FI were observed (p &gt; 0.05).ConclusionNMES therapy demonstrated minimal effect on ES morphology in patients with CLBP. Further research is needed to extend and confirm our findings.