bluuebunny/crossref_metadata_2025_split huggingface dataset:
Assessment of hydrogen peroxide as a bioindicator of stress in seaweed aquaculture
Authors: Taenzer Lina , Toth Gunilla , Hansel Colleen M. 
Published: January 2024

AbstractThe rapid expansion in commercial seaweed farming has highlighted the need for more effective monitoring methods, and health diagnostics. The production of the reactive oxygen species (ROS) hydrogen peroxide (H2O2) is a trait that is tied to all major macroalgal groups and holds significance both for its involvement in the oxidative stress response and in the production of climatically relevant gases such as halocarbons. Observations of increased production of H2O2 by plants as a stress response, along with its comparative stability and ease of quantification in seawater in comparison to other ROS, suggest that H2O2 could be used as an indicator of health. In this study we characterized aqueous H2O2 dynamics across a diel cycle, in response to small shifts in light and temperature, as well as when exposed to acute stress. Our results reveal that exposure to acute stressors leads to rapid and sustained concentrations of H2O2 that are orders of magnitude higher than changes in H2O2 concentrations observed throughout the day. These findings provide tantalizing evidence that monitoring H2O2 could be used as a health indicator in seaweed aquaculture and serve as an early warning sign of stress.
Dyeing of advanced denim fabrics (blend of cotton/bicomponent polyester filaments) using different processes and artificial intelligence method
Authors: Souissi Marwa , Chaouch Sabrine , Moussa Ali , Dhaouadi Hatem 
Published: January 2024

AbstractDenim clothes are the must-have items of clothing around the world. This kind of fabrics is evolving with the increasing consumer demand in order to keep its place as a versatile article. In this context, this paper contributes to the development and dyeing of a new blend fabric made of cotton fibers and bicomponent polyester filaments (PET/PTT). A comparative study between the mechanical and thermal properties of this fabric and conventional fabrics has confirmed the great interest to use bicomponent (PET/PTT) filaments in the manufacture of denim fabrics; these bicomponent filaments allow to give to wearer the desired elasticity and comfort. For dyeing (cotton/bicomponent polyester filaments) blend fabric, three different processes, using reactive and disperse dyes, were tested and analyzed. These dyeing processes are: two-baths/two-phases, one-bath/two-phases, and one-bath/one-phase processes. In addition, in order to obtain uniform shades between cotton fibers dyed with reactive dyes and bicomponent polyester filaments dyed with disperse dyes, an ant colony algorithm was elaborated to predict the optimal dye recipes. By observing obtained results, the developed algorithm is very effective; it allows to find the combination of reactive dyes necessary to achieve the same shade obtained by the disperse dyes with very small color differences between the two components and without having to make corrections mainly for the one-bath/two-phases process. Indeed, dyeing using the two processes (two baths/two phases and one bath/two phases) presents the best values of color yield (K/S) with almost similar results (ΔECMC(2:1) <  < 1). For the one-bath/one-phase process, it presents less significant results; We can observe ΔECMC(2:1) greater than 1 in certain shades. This is due to the strongly pH value (basic pH of 11) of reactive dyeing.
Visualization analysis of research progress for walkability
Authors: Li Xuan , Xie Dan , Zhou Zhiyu , Zhang Xin , Li Rui , Li Jiayi , Chen Zeyu , Zhang Jiayu 
Published: January 2024

AbstractThe study of walkability is of great significance to the construction of healthy cities. In this paper, taking 1283 articles of walkability, which were included in Web of Science, as the research object. This paper adopts to analysis the research progress by using the method of scientometrics and knowledge networks analysis. Objectively and systematically analyze the research progress of walkability abroad from the aspects of publication overview, knowledge foundation, research direction and hot spots, etc. It is found that foreign researches on walkability mainly include three core directions: walkability and physical activity, walkability evaluation, walkability and urban design. Among them, walkability and physical activity orientation have been studied from various perspectives, such as various groups, various environmental types, different behavioral patterns and various chronic diseases. With the increasingly prominent urbanization problems and the rapid development of new technologies, multiple data, new methods and interdisciplinary cooperation will actively promote the vigorous development of walking suitability research.
A coarse-to-fine point completion network with details compensation and structure enhancement
Authors: Miao Yongwei , Jing Chengyu , Gao Weihao , Zhang Xudong 
Published: January 2024

AbstractPoint cloud completion, the issue of estimating the complete geometry of objects from partially-scanned point cloud data, becomes a fundamental task in many 3d vision and robotics applications. To address the limitations on inadequate prediction of shape details for traditional methods, a novel coarse-to-fine point completion network (DCSE-PCN) is introduced in this work using the modules of local details compensation and shape structure enhancement for effective geometric learning. The coarse completion stage of our network consists of two branches—a shape structure recovery branch and a local details compensation branch, which can recover the overall shape of the underlying model and the shape details of incomplete point cloud through feature learning and hierarchical feature fusion. The fine completion stage of our network employs the structure enhancement module to reinforce the correlated shape structures of the coarse repaired shape (such as regular arrangement or symmetry), thus obtaining the completed geometric shape with finer-grained details. Extensive experimental results on ShapeNet dataset and ModelNet dataset validate the effectiveness of our completion network, which can recover the shape details of the underlying point cloud whilst maintaining its overall shape. Compared to the existing methods, our coarse-to-fine completion network has shown its competitive performance on both chamfer distance (CD) and earth mover distance (EMD) errors. Such as, the repairing results on the ShapeNet dataset of our completion network are reduced by an average of$$35.62\%$$35.62%,$$33.31\%$$33.31%,$$29.62\%$$29.62%, and$$23.62\%$$23.62%in terms of CD error, comparing with PCN, FoldingNet, Atlas, and CRN methods, respectively; and also reduced by an average of$$15.63\%$$15.63%,$$1.29\%$$1.29%,$$64.52\%$$64.52%, and$$62.87\%$$62.87%in terms of EMD error, respectively. Meanwhile, the completion results on the ModelNet dataset of our network have an average reduction of$$28.41\%$$28.41%,$$26.57\%$$26.57%,$$20.65\%$$20.65%, and$$18.55\%$$18.55%in terms of CD error, comparing to PCN, FoldingNet, Atlas, and CRN methods, respectively; and also an average reduction of$$21.91\%$$21.91%,$$19.59\%$$19.59%,$$43.51\%$$43.51%, and$$21.49\%$$21.49%in terms of EMD error, respectively. Our proposed point completion network is also robust to different degrees of data incompleteness and model noise.
A Late Pleistocene hominin footprint site on the North African coast of Morocco
Authors: Sedrati Mouncef , Morales Juan A. , Duveau Jérémy , M’rini Abdelmounim El , Mayoral Eduardo , Díaz‐Martínez Ignacio , Anthony Edward J. , Bulot Glen , Sedrati Anass , Le Gall Romain , Santos Ana , Rivera-Silva Jorge 
Published: January 2024

AbstractFootprints represent a relevant vestige providing direct information on the biology, locomotion, and behaviour of the individuals who left them. However, the spatiotemporal distribution of hominin footprints is heterogeneous, particularly in North Africa, where no footprint sites were known before the Holocene. This region is important in the evolution of hominins. It notably includes the earliest currently known Homo sapiens (Jebel Irhoud) and the oldest and richest African Middle Stone Age hominin sites. In this fragmented ichnological record, we report the discovery of 85 human footprints on a Late Pleistocene now indurated beach surface of about 2800 m2 at Larache (Northwest coast of Morocco). The wide range of sizes of the footprints suggests that several individuals from different age groups made the tracks while moving landward and seaward across a semi-dissipative bar-trough sandy beach foreshore. A geological investigation and an optically stimulated luminescence dating of a rock sample extracted from the tracksite places this hominin footprint surface at 90.3 ± 7.6 ka (MIS 5, Late Pleistocene). The Larache footprints are, therefore, the oldest attributed to Homo sapiens in Northern Africa and the Southern Mediterranean.
Quantitative assessment and optimization of parallel contact model for flexible paddy straw: a definitive screening and central composite design approach using discrete element method
Authors: Patel Abhishek , Singh Krishna Pratap , Roul Ajay Kumar , Nalawade Rohit Dilip , Mahore Aman , Kumar Mohit , Avilala Prasad , Ramulu Chelpuri , Kebede Berhanu , Patra Abhik 
Published: January 2024

AbstractTo simulate the bending behaviour of paddy straw at varied moisture contents after crop harvesting, we created a flexible paddy straw specimen model based on the Hertz–Mindlin with parallel contact bonding model using the discrete element model (DEM) approach. The research presented in this study aims to investigate a new approach called Definitive Screening Design (DSD) for parameterizing and screening the most significant parameters of the DEM model. This investigation will specifically focus on the three-point bending test as a means of parameterization, and the shear plate test will be used for validation purposes. In addition, the most influential DEM parameters were optimized using another Design of Experiments approach called Central Composite Design. The findings from the DSD indicated that parameters such as bonded disk scale, normal stiffness, and shear stiffness have the highest impact on the bending force, while the coefficient of static friction (Straw-Steel) has the least effect. The three bonding parameters were respectively calibrated with the loading rate (0.42, 0.5, and 0.58 mm s−1) and a good agreement between actual and simulated shear force at moisture content M1—35 ± 3.4%, M2—24 ± 2.2% and M3—17 ± 2.6%. Modelled stem helps simulate the straw with low error and increases the accuracy of the simulation. The validated model, with an average relative error of 5.43, 7.63, and 8.86 per cent, produced reasonable agreement between measured and simulated shear force value and loading rate.
Bioinformatic analysis reveals an association between Metadherin with breast cancer prognosis and tumor immune infiltration
Authors: Yang Lixian , Yang Liu , Kong Fanting , Zhang Shiyu , Pu Pengpeng , Li Xiaowei , Song Zhenchuan 
Published: January 2024

AbstractBreast cancer metastasis and invasion are both promoted by the oncoprotein Metadherin (MTDH). However, the the role of Metadherin in breast cancer progression and its role in the immune microenvironment. Are not clear. A bioinformatic analysis was performed to demonstrate the prognostic value of Metadherin in BC. In the present study, we found that Metadherin is overexpressed in BC and is significantly correlated with individual cancer stage, age, subclasses, menopause and nodal metastasis status. Metadherin overexpression was associated with a significant decrease in OS and DSS. Cox multivariate analysis indicated that Metadherin was an independent negative prognostic indicator for OS and DSS. Moreover, Metadherin hypomethylation status was associated with poor prognosis. A negative correlation was also noted between Metadherin overexpression and the number of plasmacytoid dendritic cells, cluster of differentiation 8+ T cells, and natural killer cells. Association patterns varied with different subtypes. Various associations between Metadherin levels and immune cell surface markers were revealed. A total of 40 groups of BC and adjacent normal breast tissue samples were collected. Metadherin mRNA was detected by PCR, and its expression levels in BC tissues were significantly increased compared with those noted in normal tissues. The expression levels of Metadherin were also measured in normal and BC cell lines, respectively, and similar conclusions were obtained. The Metadherin mRNA levels were knocked down in SK-BR3 and MDA-MB-231 cell lines and the cell proliferative and migratory activities were determined using Cell Counting Kit-8 and scratch assays, respectively. The results indicated that the cell proliferative and migratory abilities were reduced following knockdown of Metadherin expression. Therefore, Metadherin may be considered as a novel prognostic biomarker in BC.
Factors influencing pain medication and opioid use in patients with musculoskeletal injuries: a retrospective insurance claims database study
Authors: Scholz Stefan Markus , Thalmann Nicolas Fabrice , Müller Dominic , Trippolini Maurizio Alen , Wertli Maria Monika 
Published: January 2024

AbstractOpioid use is only recommended in selected cases of musculoskeletal (MSK) injuries. We assessed factors associated with increased opioid use in MSK injuries. In a retrospective analysis of over four million workers with MSK injuries using the Swiss National Accident Insurance Fund (Suva) database, we analyzed risk factors by multivariate logistic regression. Injury severity was associated with pain medication, opioid, and strong opioid use. Whereas fractures, contusions, and ruptures had higher odds for any pain medication use, increased odds for strong opioids were observed in fractures, superficial injuries, and other injuries. Injuries of the shoulders, elbow, chest, back/spine, thorax, and pelvis/hips showed high odds for opioid use (odds ratio (OR) > 2.0). Injuries of the shoulders had higher odds for strong opioid use (OR 1.136; 95% CI 1.040–1.241). The odds for using strong opioids increased from 2008 OR 0.843 (95% confidence interval (CI) 0.798–0.891) to 2018 OR 1.503 (95% CI 1.431–1.578), compared to 2013. Injury severity, type of injury, and injured body parts influenced the use of pain medication and overall opioid use in musculoskeletal injuries. Strong opioids were more often used in fractures but also in superficial and other minor injuries, which indicates that other factors play a role when prescribing strong opioids.
Structural and biochemical rationale for Beta variant protein booster vaccine broad cross-neutralization of SARS-CoV-2
Authors: Bruch Eduardo M. , Zhu Shaolong , Szymkowicz Lisa , Blake Taylor , Kiss Tara , James D. Andrew , Rak Alexey , Narayan Kartik , Balmer Matthew T. , Chicz Roman M. 
Published: January 2024

AbstractSevere acute respiratory syndrome coronavirus 2 (SARS-CoV-2), responsible for the COVID-19 pandemic, uses a surface expressed trimeric spike glycoprotein for cell entry. This trimer is the primary target for neutralizing antibodies making it a key candidate for vaccine development. During the global pandemic circulating variants of concern (VOC) caused several waves of infection, severe disease, and death. The reduced efficacy of the ancestral trimer-based vaccines against emerging VOC led to the need for booster vaccines. Here we present a detailed characterization of the Sanofi Beta trimer, utilizing cryo-EM for structural elucidation. We investigate the conformational dynamics and stabilizing features using orthogonal SPR, SEC, nanoDSF, and HDX-MS techniques to better understand how this antigen elicits superior broad neutralizing antibodies as a variant booster vaccine. This structural analysis confirms the Beta trimer preference for canonical quaternary structure with two RBD in the up position and the reversible equilibrium between the canonical spike and open trimer conformations. Moreover, this report provides a better understanding of structural differences between spike antigens contributing to differential vaccine efficacy.
Prevalence and predictors of poor self-care behaviors in patients with chronic heart failure
Authors: Niriayo Yirga Legesse , Yemane Bisrat , Asgedom Solomon Weldegebreal , Teklay Gebrehiwot , Gidey Kidu 
Published: January 2024

AbstractDespite the indispensable role of self-care behavior in managing heart failure, the practice of self-care behavior remains poor, especially in developing countries. There is a scarcity of research focusing on poor self-care behavior and its determinants within our specific context. Therefore, the objective of this study was to investigate the prevalence and predictors of poor self-care behavior among ambulatory heart failure patients. A facility-based cross-sectional study was conducted at a tertiary care hospital in Ethiopia, involving patients with heart failure. We utilized the European Heart Failure Self-Care Behavior Scale (EHFScBS-9) to evaluate adherence to self-care behaviors. Data were gathered through patient interviews and a review of medical records. A binary logistic regression analysis was performed to identify predictors of poor self-care behavior in heart failure patients. We included a total of 343 participants in the final analysis of this study. The findings revealed that a majority of the patients (73.8%) demonstrated poor overall self-care behavior. Specifically, the majority of patients did not engage in regular exercise (76.1%), failed to consult doctors in case of rapid weight gain (75.6%), did not monitor weight daily (71.5%), did not restrict fluid intake (69.9%), and did not contact doctors in case of experiencing fatigue (68.6%). Additionally, 32.4% of patients did not reach out to doctors when experiencing shortness of breath, 30% did not restrict salt intake, 29% did not adhere to prescribed medication, and only 7% did not consult doctors if edema occurred. Our findings indicated that rural residence (AOR: 5.76, 95% CI: 2.47–13.43), illiteracy (AOR: 2.64, 95% CI: 1.52–6.31), prior hospitalization (AOR: 2.09, 95% CI: 1.21–3.61), and taking five or more medications (AOR: 1.83, 1.01–3.33) were significant predictors of poor self-care behavior. In conclusion, a majority of the participants in our study demonstrated poor self-care behavior. Risk factors for this behavior included rural residence, illiteracy, prior hospitalization, and taking five or more medications. Therefore, it is crucial to prioritize these high-risk patients and implement interventional programs aimed at improving self-care behaviors and overall treatment outcomes in heart failure patients.
Targeting ocean conservation outcomes through threat reduction
Authors: Turner Joseph A. , Starkey Malcolm , Dulvy Nicholas K. , Hawkins Frank , Mair Louise , Serckx Adeline , Brooks Thomas , Polidoro Beth , Butchart Stuart H. M. , Carpenter Kent , Epps Minna , Jabado Rima W. , Macfarlane Nicholas B. W. , Bennun Leon 
Published: January 2024

AbstractNations have committed to reductions in the global rate of species extinctions through the Sustainable Development Goals 14 and 15, for ocean and terrestrial species, respectively. Biodiversity loss is worsening despite rapid growth in the number and extent of protected areas, both at sea and on land. Resolving this requires targeting the locations and actions that will deliver positive conservation outcomes for biodiversity. The Species Threat Abatement and Restoration (STAR) metric, developed by a consortium of experts, quantifies the contributions that abating threats and restoring habitats in specific places offer towards reducing extinction risk based on the IUCN Red List of Threatened SpeciesTM. STAR is now recommended as an appropriate metric by recent disclosure frameworks for companies to report their impacts on nature and STAR has seen widespread uptake within the private sector. However, it is currently only available for the terrestrial realm. We extend the coverage of the threat abatement component of the STAR metric (START), used to identify locations where positive interventions could make a large contribution to reducing global species extinction risk and where developments that increase threats to species should be mitigated, to the marine realm for 1646 marine species. Reducing unsustainable fishing provides the greatest opportunity to lower species extinction risk, comprising 43% of the marine STARTscore. Three-quarters (75%) of the global marine STARTscore falls entirely outside the boundaries of protected areas and only 2.7% falls within no-take protected areas. The STAR metric can be used both to guide protected area expansion and to target other actions, such as establishment and enforcement of fishing limits, to recover biodiversity.
A Phase 2 study of nivolumab in combination with modified FOLFIRINOX for metastatic pancreatic cancer
Authors: Morizane Chigusa , Ueno Makoto , Ikeda Masafumi , Sudo Kentaro , Hirashima Yoshinori , Kuroda Masataka , Ueno Shinji , Okusaka Takuji , Furuse Junji 
Published: January 2024

Abstract
Background
Nivolumab with modified FOLFIRINOX (mFOLFIRINOX) may have additive antitumour effects while minimising chemotherapy cytotoxicity. We assessed the efficacy and safety of nivolumab+mFOLFIRINOX in metastatic pancreatic cancer.

Methods
Thirty-one treatment-naïve patients aged ≥20 years with metastatic unresectable/recurrent pancreatic cancer (≥1 measurable lesion per Response Evaluation Criteria in Solid Tumours version 1.1) and Eastern Cooperative Oncology Group 0/1 score and life expectancy ≥90 days received nivolumab (480 mg, every 4 weeks) plus mFOLFIRINOX. The primary endpoint was objective response rate (ORR). Secondary endpoints included overall survival (OS), progression-free survival (PFS) and safety.

Results
At the median follow-up of 13.4 months, the ORR was 32.3% (complete response 0%; partial response 32.3%) and the median duration of response was 7.4 (range: 3.5–21.9) months; the primary endpoint was not met. Median OS and PFS were 13.4 (95% confidence interval [CI]: 10.6–16.6) months and 7.4 (95% CI: 3.9–9.2) months, respectively. The 1-year survival rate was 54.8% (95% CI: 36.0%–70.3%). Drug-related serious adverse events were reported in 29.0% of the patients; 3.2% drug-related adverse events led to discontinuation, and none led to death within 30-day safety window.

Conclusion
Nivolumab+mFOLFIRINOX was tolerable in patients with metastatic pancreatic cancer. ORR and survival were comparable to previously reported data. (JapicCTI-184230)