bluuebunny/crossref_metadata_2025_split huggingface dataset:
Genetic analyses identify brain imaging-derived phenotypes associated with the risk of intracerebral hemorrhage
Authors: Liu Yi , Jia Yiming , Sun Hongyan , Sun Lulu , Wang Yinan , Xu Qingyun , He Yu , Chang Xinyue , Guo Daoxia , Shi Mengyao , Chen Guo-Chong , Zheng Jin , Zhu Zhengbao 
Published: January 2024

Abstract
Previous observational studies have reported associations between brain imaging-derived phenotypes (IDPs) and intracerebral hemorrhage (ICH), but the causality between them remains uncertain. We aimed to investigate the potential causal relationship between IDPs and ICH by a two-sample Mendelian randomization (MR) study. We selected genetic instruments for 363 IDPs from a genome-wide association study (GWASs) based on the UK Biobank (n = 33,224). Summary-level data on ICH was derived from a European-descent GWAS with 1,545 cases and 1,481 controls. Inverse variance weighted MR method was applied in the main analysis to investigate the associations between IDPs and ICH. Reverse MR analyses were performed for significant IDPs to examine the reverse causation for the identified associations. Among the 363 IDPs, isotropic or free water volume fraction (ISOVF) in the anterior limb of the left internal capsule was identified to be associated with the risk of ICH (OR per 1-SD increase, 4.62 [95% CI, 2.18–9.81], P = 6.63 × 10−5). In addition, the reverse MR analysis indicated that ICH had no effect on ISOVF in the anterior limb of the left internal capsule (beta, 0.010 [95% CI, −0.010-0.030], P = 0.33). MR-Egger regression analysis showed no directional pleiotropy for the association between ISOVF and ICH, and sensitivity analyses with different MR models further confirmed these findings. ISOVF in the anterior limb of the left internal capsule might be a potential causal mediator of ICH, which may provide predictive guidance for the prevention of ICH. Further studies are warranted to replicate our findings and clarify the underlying mechanisms.
Finger motor representation supports the autonomy in arithmetic: neuroimaging evidence from abacus training
Authors: Wang Yanjie , Zhang Yi , Xu Tianyong , Han Xiao , Ge Xuelian , Chen Feiyan 
Published: January 2024

Abstract
Researches have reported the close association between fingers and arithmetic. However, it remains unclear whether and how finger training can benefit arithmetic. To address this issue, we used the abacus-based mental calculation (AMC), which combines finger training and mental arithmetic learning, to explore the neural correlates underlying finger-related arithmetic training. A total of 147 Chinese children (75 M/72 F, mean age, 6.89 ± 0.46) were recruited and randomly assigned into AMC and control groups at primary school entry. The AMC group received 5 years of AMC training, and arithmetic abilities and resting-state functional magnetic resonance images data were collected from both groups at year 1/3/5. The connectome-based predictive modeling was used to find the arithmetic-related networks of each group. Compared to controls, the AMC’s positively arithmetic-related network was less located in the control module, and the inter-module connections between somatomotor-default and somatomotor-control modules shifted to somatomotor-visual and somatomotor-dorsal attention modules. Furthermore, the positive network of the AMC group exhibited a segregated connectivity pattern, with more intra-module connections than the control group. Overall, our results suggested that finger motor representation with motor module involvement facilitated arithmetic-related network segregation, reflecting increased autonomy of AMC, thus reducing the dependency of arithmetic on higher-order cognitive functions.
Carbon disulfide induces accumulation of TDP-43 in the cytoplasm and mitochondrial dysfunction in rat spinal cords
Authors: Liu Zhidan , Qiang Yalong , Shan Shulin , Wang Shuai , Song Fuyong 
Published: January 2024

Abstract
The relationship between environmental neurotoxicant exposure and neurodegenerative diseases is being extensively investigated. Carbon disulfide, a classic neurotoxicant and prototype of dithiocarbamates fungicides and anti-inflammatory agents, has been detected in urban adults, raising questions about whether exposure to carbon disulfide is associated with a high incidence of neurodegenerative diseases. Here, using rat models and SH-SY5Y cells, we investigated the possible mechanistic linkages between carbon disulfide neurotoxicity and the expression of TDP-43 protein, a marker of amyotrophic lateral sclerosis/frontotemporal lobar degeneration. Our results showed that rats exhibited severe dyskinesia and increased TDP-43 expression in the spinal cord following carbon disulfide exposure. Moreover, carbon disulfide exposure induced abnormal cytoplasmic localization and phosphorylation of TDP-43 in motor neurons. Importantly, carbon disulfide treatment led to the accumulation of TDP-43 in the mitochondria of motor neurons and resulted in subsequent mitochondrial damage, including mitochondrial structural disruption, mitochondrial respiratory chain complex I inhibition, and impaired VCP/p97-dependent mitophagy. In summary, our study provides support for carbon disulfide exposure-mediated TDP-43 mislocalization and mitochondrial dysfunction, contributes to understanding the pathogenesis of environmental neurotoxin-induced neurodegeneration, and provides inspiration for potential therapeutic strategies.
Effect of Ca addition on near-infrared reflection of SrCuSi4O10
Authors: Obata Kenji , Konishi Rin , Okagami Aoshi , Matsushima Shigenori 
Published: January 2024

Abstract
In this study, SrCuSi4O10 powders were synthesized by a complex polymerization method and the effect of Ca addition on the crystal structure and optical properties in the visible and near-infrared regions was examined. Crystalline SrCuSi4O10 was formed at 1,000 °C in air. From the X-ray diffraction measurements, the (002) and (004) reflections of SrCuSi4O10 shifted to higher angles, and the lattice parameter (a and c) decreased with the addition of Ca, suggesting that Ca was successfully introduced into SrCuSi4O10. However, the lattice constant of SrCuSi4O10 increased with further addition of Ca to 10 mol%. Optical measurements of SrCuSi4O10 identified three optical absorption bands in the visible light region, attributed to the d–d transition of Cu2+: namely 2B1g → 2B2g (540 nm), 2B1g → 2Eg (628 nm), and 2B1g → 2A1g (800 nm). The addition of Ca decreased the intensity of these absorptions. The –b* value, which indicates blueness, was estimated using the L*a*b* color system, and SrCuSi4O10 with 5 mol% Ca showed the highest value among the measured samples. On the other hand, the reflectance of SrCuSi4O10 in the near-infrared region increased significantly with the addition of Ca. These results indicate that Ca addition is effective in improving the blue coloration and near-infrared reflectivity of SrCuSi4O10.
Severe aortic stenosis: secular trends of incidence and outcomes
Authors: Benfari Giovanni , Essayagh Benjamin , Michelena Hector I , Ye Zi , Inojosa Jose Medina , Ribichini Flavio L , Crestanello Juan , Messika-Zeitoun David , Prendergast Bernard , Wong Benjamin F , Thapa Prabin , Enriquez-Sarano Maurice 
Published: January 2024

Abstract

Background and Aims
Severe aortic stenosis (AS) is the guideline-based indication for aortic valve replacement (AVR), which has markedly increased with transcatheter approaches, suggesting possible increasing AS incidence. However, reported secular trends of AS incidence remain contradictory and lack quantitative Doppler echocardiographic ascertainment.

Methods
All adults residents in Olmsted County (MN, USA) diagnosed over 20 years (1997–2016) with incident severe AS (first diagnosis) based on quantitatively defined measures (aortic valve area ≤ 1 cm2, aortic valve area index ≤ 0.6 cm2/m2, mean gradient ≥ 40 mmHg, peak velocity ≥ 4 m/s, Doppler velocity index ≤ 0.25) were counted to define trends in incidence, presentation, treatment, and outcome.

Results
Incident severe AS was diagnosed in 1069 community residents. The incidence rate was 52.5 [49.4–55.8] per 100 000 patient-year, slightly higher in males vs. females and was almost unchanged after age and sex adjustment for the US population 53.8 [50.6–57.0] per 100 000 residents/year. Over 20 years, severe AS incidence remained stable (P = .2) but absolute burden of incident cases markedly increased (P = .0004) due to population growth. Incidence trend differed by sex, stable in men (incidence rate ratio 0.99, P = .7) but declining in women (incidence rate ratio 0.93, P = .02). Over the study, AS clinical characteristics remained remarkably stable and AVR performance grew and was more prompt (from 1.3 [0.1–3.3] years in 1997–2000 to 0.5 [0.2–2.1] years in 2013–16, P = .001) but undertreatment remained prominent (&gt;40%). Early AVR was associated with survival benefit (adjusted hazard ratio 0.55 [0.42–0.71], P &lt; .0001). Despite these improvements, overall mortality (3-month 8% and 3-year 36%), was swift, considerable and unabated (all P ≥ .4) throughout the study.

Conclusions
Over 20 years, the population incidence of severe AS remained stable with increased absolute case burden related to population growth. Despite stable severe AS presentation, AVR performance grew notably, but while declining, undertreatment remained substantial and disease lethality did not yet decline. These population-based findings have important implications for improving AS management pathways.
A cross-sectional nationwide survey of guideline based syncope units in the Netherlands: the SU-19 score—a novel validation for best practices
Authors: van Zanten Steven , de Jong Jelle S Y , Scheffer Mike G , Kaal Evert C A , de Groot Joris R , de Lange Frederik J 
Published: January 2024

Abstract

Aims
We aimed to identify all syncope units (SUs) in the Netherlands and assess the extent to which these SUs fulfil the essential requirements outlined by the consensus statements of the European Heart Rhythm Association and the European Society of Cardiology syncope guidelines. For this, we developed the SU-19 score, a novel guideline based validation tool for best practice.

Methods and results
All outpatient clinics of cardiology, neurology, and internal medicine in the Netherlands were screened for presence of any form of structured specialized syncope care. If present, these were included as SUs and requested to complete a questionnaire regarding syncope care. We assessed all SUs using the SU-19 score regarding structure (3 points), available tests (12 points), and initial evaluation (4 points). Twenty SUs were identified in the Netherlands, both academic (5/20) and non-academic hospitals (15/20), 17/20 reported multidisciplinary involvement during initial evaluation. In 19/20, neurology, cardiology, or both were responsible for the syncope management. Non-physicians were involved performing the head-up tilt test (44%) and initial evaluation (40%). The mean SU-19 score was 18.0 ± 1.1, 45% achieved the maximum score of 19 points. Variations were observed in protocols for active standing test, carotid sinus massage, and head-up tilt test.

Conclusion
There is a network of 20 SUs in the Netherlands. Forty-five per cent fully met the SU-19 score (mean 18.0 ± 1.1). Slight variety existed in protocols for autonomic function tests. Neurology and cardiology were mostly involved in syncope management. Non-physicians play an important role in syncope care.
Small states and the dilemma of geopolitics: role change in Finland and Sweden
Authors: Michalski Anna , Brommesson Douglas , Ekengren Ann-Marie 
Published: January 2024

Abstract
This article focuses on foreign policy role change in small liberal states caused by a weakening rules-based order illustrated by the decisions of Finland and Sweden to apply for membership of NATO, thereby abandoning longstanding policies of military non-alignment. Although both countries sought alignment with NATO in the context of intense security threats in northern Europe, the domestic processes of foreign policy role change proceeded along different trajectories. In Finland, the domestic process of role change was characterized by strong elite and public consensus on membership of NATO, whereas in Sweden there was more hesitation regarding giving up military non-alignment and losing freedom of action. In this article, we address a gap in the literature on role theory and domestic role change by conceptualizing the dilemma of small liberal states being compelled to reassess national role conceptions in their domestic settings in the face of external challenges outside their control, without jeopardizing national autonomy and deep-seated social identities. To this end, we construct a model for national action strategies based on scope conditions of domestic role change, varying according to the level of congruence in national identity and the degree of domestic elite consensus concerning national foreign policy.
The scholarship–practitioner nexus: lessons from Latin American foreign policy
Authors: Deciancio Melisa 
Published: January 2024

Abstract
Various studies have explored the role of International Relations research in policy-making, predominantly focusing on countries in the global North. However, there needs to be a better understanding of this dynamic in peripheral countries of the global South. This article addresses this gap by examining the relationship between theory and practice in Latin American foreign policy; the synergy between scholarly research and practical implementation offers valuable insights. This interplay sheds light on the impact research can have by developing unique theoretical frameworks and guiding current foreign policy strategies. Using Argentine foreign policy as a case-study, I explore specialized knowledge networks that have driven foreign policy studies, their inception in Latin America and pivotal theoretical developments that have influenced both academia and policy. Employing qualitative analysis, I triangulate data from diverse sources such as archives, official documents, journals, institutional histories, reports and expert interviews. This investigation underscores the collaborative efforts of Latin American scholars and policy-makers, driven by a shared goal to address regional challenges through both theoretical insights and practical solutions.
Circulating miR-199a and long noncoding-RNA ANRIL as Promising Diagnostic Biomarkers for Inflammatory Bowel Disease
Authors: Erfan Randa , Shaker Olfat G , Khalil Mahmoud A F , Mahmoud Fatma A M , Gomaa Mohamed S , Abu-El-Azayem Abeer K , Zaki Othman M , Ahmed Azza M , Samy Amira , Mohammed Asmaa 
Published: January 2024

Abstract

Background & Aims
Inflammatory bowel disease (IBD), involving both Crohn’s disease (CD) and ulcerative colitis (UC), represents a chronic, immune-mediated inflammatory disease due to an uncontrolled, ongoing inflammatory response to intestinal bacteria in those with genetic susceptibility. MicroRNA (miRNA) extrusion from relevant remote organs or tissues is reflected in the expression of miRNAs in serum and plasma. Both UC and CD patients had higher blood levels of expressed miR-199a. Long noncoding RNA (lncRNA) ANRIL is a proinflammatory gene that mediates nuclear factor κB to play a role in inflammatory diseases, such as IBD. The aim of the current study is to investigate the potential role of both miR-199a and ANRIL in diagnosing IBD in adult patients.

Methods
Sixty-seven IBD patients diagnosed clinically, radiologically, endoscopically, and histologically were included in this prospective cohort study. Participants were classified into 3 groups: the UC group (n = 35), the CD group (n = 32), and the control group (n = 30). Demographics, history taking, laboratory characteristics, and treatments were recorded. Tumor necrosis factor α, miR-199a, and ANRIL were measured.

Results
The findings suggested that miR-199a and ANRIL might be associated with the occurrence or progression of IBD because both genes were substantially expressed in the peripheral blood of patients with this condition. Receiver-operating characteristic curve analysis indicated that the detection of miR-199a and ANRIL had a predictive sensitivity of 62.9% and 88.6% and a specificity of 70.7% and 96.7% for the occurrence of UC cases, respectively, and a predictive sensitivity of 72.4% and 46.9% and a specificity of 96.7% and 34.7% for the occurrence of CD cases, respectively.

Conclusions
Both miR-199a and ANRIL are abundant in the sera of IBD adult Egyptian patients (UC and CD). Both can represent a noninvasive marker for early disease diagnosis.
Durability of Adalimumab and Infliximab in Children With Crohn’s Disease: A Nationwide Comparison From the epi-IIRN Cohort
Authors: Atia Ohad , Friss Chagit , Focht Gili , Magen Rimon Ramit , Ledderman Natan , Ben-Tov Amir , Loewenberg Weisband Yiska , Matz Eran , Gorelik Yuri , Chowers Yehuda , Dotan Iris , Turner Dan 
Published: January 2024

Abstract

Background
In a nationwide cohort, we aimed to compare the durability of infliximab and adalimumab as first biologic treatment in children with Crohn’s disease (CD), stratified as combotherapy or monotherapy.

Methods
We used data from the epi-IIRN cohort that includes all patients with inflammatory bowel diseases in Israel. Durability was defined as consistent treatment without surgery or treatment escalation. All comparisons followed stringent propensity-score matching in Cox proportional hazard models.

Results
Of the 3487 children diagnosed with CD since 2005, 2157 (62%) received biologics (1127 [52%] infliximab, 964 [45%] adalimumab and 52 [2%] vedolizumab as first biologic), representing a higher proportion than that among adults diagnosed during the same time period (5295 of 15 776 [34%]; P &lt; .001). Time from diagnosis to initiation of biologic was shorter in pediatric-onset compared with adult-onset disease (median time during the last 3 years was 2.7 months [interquartile range 1.2-5.4] vs 5.2 months [2.6-8.9]; P &lt; .001). The durability of adalimumab monotherapy after 1 and 5 years from initiation of treatment was better than infliximab monotherapy (79%/54% vs 67%/37%, respectively; n = 452 matched children; hazard ratio [HR], 1.7; 95% confidence interval [CI], 1.3-2.3; P &lt; .001), while in those treated with combotherapy, durability was similar (94%/66% with infliximab vs 90%/54% with adalimumab; n = 100; HR, 1.7; 95% CI, 0.9-3.3; P = .1). Durability was higher in children treated with infliximab combotherapy vs infliximab monotherapy (87%/45% vs 75%/39%; n = 440; HR, 1.4; 95% CI, 1.1-1.8; P = .01). The durability of adalimumab monotherapy was similar to infliximab combotherapy (83%/53% vs 89%/56%, respectively; n = 238; HR, 0.9; 95% CI, 0.7-1.2; P = .4).

Conclusion
Our results support using adalimumab monotherapy as a first-line biologic in children with CD. When infliximab is used, combotherapy may be advantageous over monotherapy.
Using fisheries-dependent data to investigate landings of European lobster (Homarus gammarus) within an offshore wind farm
Authors: Thatcher Harry , Stamp Thomas , Moore Pippa J , Wilcockson David 
Published: January 2024

Abstract
The need for alternative strategies to assist in the monitoring and sustainable management of fisheries’ resources is becoming increasingly important. In recent years, greater utilization of fishers’ knowledge has been advocated as a potentially valuable source of data that could be applied to fisheries management issues. In the current study, we addressed this by investigating the landing per unit effort (LPUE) of European lobster (Homarus gammarus) from within an offshore wind farm using a fisheries-dependent commercial fishing logbook. The logbook was provided by a single fisherman who targeted lobsters within the wind farm between 2015 and 2022 using single pots deployed in association with individual wind turbines. Generalized linear mixed modeling was used to investigate changes in LPUE over temporal scales and as the result of the presence of scour protection at turbine locations. LPUE was found to be significantly higher at turbine locations where scour protection was present compared to those turbines where it was not. Predictions from modeling suggested LPUE was nearly 1.5× greater at turbines where scour protection was present. Significant differences in mean monthly and yearly LPUE were detected with this variation likely to reflect seasonal changes in lobster activity and the effect of introducing fishing into a previously unfished area. This work highlights the potential for fishing logbooks to be applied in fisheries management. Our results also demonstrate potential fishing opportunities arising from the development of offshore wind farms and the potential for these opportunities to be enhanced.
LGBT+ rights claims for marriage equality and the possibilities of transforming Indian family law
Authors: Agarwal Akshat 
Published: January 2024

Abstract
The Indian Supreme Court decriminalized homosexuality in 2018 and recognized the equal constitutional citizenship of LGBT+ Indians. Since then, several petitions seeking marriage equality have been filed before Indian courts. In parallel, critics have argued that traditional approaches to LGBT+ equality ignore problematic family law institutions, and have stressed the need to think beyond legal inclusion to recognize diverse families. These arguments are not unique to India. Claiming LGBT+ rights within existing family law institutions has divided LGBT+ activists the world over. The commonly advanced argument is that assimilation into existing patriarchal social institutions disregards radical transformational possibilities. However, experiences in jurisdictions like the United States challenge this premise and show how family law can potentially be transformed through LGBT+ rights claims. While we still await an authoritative judicial pronouncement on marriage equality in India, this article argues that legally recognizing marriage equality may positively impact existing family laws by generating arguments for expanding recognition of diverse families. It shows that achieving marriage equality through the recognition of LGBT+ relational rights, comprising LGBT+ family equality and the right to legal recognition of LGBT+ relationships, has the potential for progressively expanding Indian parenthood laws. The article specifically demonstrates how this is possible in guardianship, assisted reproduction, and adoption laws and may benefit diverse different-sex families, single parents, and persons in non-marital relationships.
Trends in cell medicine: from autologous cells to allogeneic universal-use cells for adoptive T-cell therapies
Authors: Kawamoto Hiroshi , Masuda Kyoko 
Published: January 2024

Abstract
In currently ongoing adoptive T-cell therapies, T cells collected from patients are given back to them after ex vivo activation and expansion. In some cases, T cells are transduced with chimeric antigen receptor (CAR) or T-cell receptor (TCR) genes during the ex vivo culture period in order to endow T cells with the desired antigen specificity. Although such strategies are effective in some types of cancer, there remain issues to be solved: (i) the limited number of cells, (ii) it is time-consuming, (iii) it is costly, and (iv) the quality can be unstable. Points (ii) and (iv) can be solved by preparing allogeneic T cells and cryopreserving them in advance and methods are being developed using healthy donor-derived T cells or pluripotent stem cells as materials. Whereas it is difficult to solve (i) and (iii) in the former case, all the issues can be cleared in the latter case. However, in either case, a new problem arises: rejection by the patient’s immune system. Deletion of human leukocyte antigen (HLA) avoids rejection by recipient T cells, but causes rejection by NK cells, which can recognize loss of HLA class I. Various countermeasures have been developed, but no definitive solution is yet available. Therefore, further research and development are necessary.