bluuebunny/crossref_metadata_2025_split huggingface dataset:
The value of TDI combined with myocardial strain parameters in quantitative evaluation of left heart function in parturient with pregnancy-induced hypertension
Authors: Lin Xiumei , Lu Chengwei , Ma Guifeng 
Published: December 2023

AbstractThis study aimed to investigate the value of tissue doppler imaging (TDI) and 4D myocardial strain parameters in evaluating left heart function of pregnant women with hypertension and the association between these parameters and relevant factors. Forty-five pregnant women with hypertensive disorder, including 20 with hypertension, 15 with mild preeclampsia, and 10 with severe preeclampsia, were recruited, and their cardiac functions were compared with those of 30 healthy pregnant women as controls. High Left ventricular end-systolic volume (LVESV), Left atrial volume index (LAVI), E/e were observed in hypertensive disorder, while Mitral peak diastolic velocity(E), Early diastolic peak velocity(e), E/A, Left ventricularglobal longitudinal strain (LVGLS), Left ventricularglobal area strain (LVGAS), and Left atrialglobal longitudinal strain (LAGLS) were decreased; for pre-eclampsia, Left ventricular end-systolic diameter (LVESD), Left atrial anteroposterior diameter (LAD-ap), LVESV, LAVI were significantly increased, LVGLS, LAGLS were significantly decreased, Left ventricular end-diastolic diameter (LVEDD), Left ventricular end-diastolic volume (LVEDV), A peak, E/e were increased, while E peak, E/A, e, Left ventricle global radial strain (LVGRS), Left ventricle global circumferential strain (LVGCS), LVGAS were decreased but not significantly; for severe preeclampsia, Left ventricular end diastolic diameter (LVEDD), LVESD, LAD-ap, Left ventricular end-diastolic volume (LVEDV), LVESV, LAVI, A, and E/e were significantly increased, while LVGLS, LVGRS, LVGCS, LVGAS, LAGLS, E peak, E/A, and e were significantly reduced. TDI combined with 4D myocardial strain parameters can detect early changes in cardiac function of hypertensive disorders in pregnancy, with LVGLS, LVGAS, and LAGLS being the most sensitive indicators for early changes. Such findings provide a basis for effective clinical treatment of these symptoms.
Forecasting local hospital bed demand for COVID-19 using on-request simulations
Authors: Kociurzynski Raisa , D’Ambrosio Angelo , Papathanassopoulos Alexis , Bürkin Fabian , Hertweck Stephan , Eichel Vanessa M. , Heininger Alexandra , Liese Jan , Mutters Nico T. , Peter Silke , Wismath Nina , Wolf Sophia , Grundmann Hajo , Donker Tjibbe 
Published: December 2023

AbstractAccurate forecasting of hospital bed demand is crucial during infectious disease epidemics to avoid overwhelming healthcare facilities. To address this, we developed an intuitive online tool for individual hospitals to forecast COVID-19 bed demand. The tool utilizes local data, including incidence, vaccination, and bed occupancy data, at customizable geographical resolutions. Users can specify their hospital’s catchment area and adjust the initial number of COVID-19 occupied beds. We assessed the model’s performance by forecasting ICU bed occupancy for several university hospitals and regions in Germany. The model achieves optimal results when the selected catchment area aligns with the hospital’s local catchment. While expanding the catchment area reduces accuracy, it improves precision. However, forecasting performance diminishes during epidemic turning points. Incorporating variants of concern slightly decreases precision around turning points but does not significantly impact overall bed occupancy results. Our study highlights the significance of using local data for epidemic forecasts. Forecasts based on the hospital’s specific catchment area outperform those relying on national or state-level data, striking a better balance between accuracy and precision. These hospital-specific bed demand forecasts offer valuable insights for hospital planning, such as adjusting elective surgeries to create additional bed capacity promptly.
Risk factors for arteriovenous fistula dysfunction in hemodialysis patients: a retrospective study
Authors: Zhang Fan , Li Jiali , Yu Jie , Jiang Yang , Xiao Hailang , Yang Yiya , Liang Yumei , Liu Kanghan , Luo Xun 
Published: December 2023

AbstractArteriovenous fistula (AVF) is the first choice of vascular access in hemodialysis (HD) patients. However, the correlations between patient factors and the arteriovenous fistula patency remain unclear. Therefore, our study investigates the risk factors associated with AVF dysfunction in HD patients. A total of 233 end-stage renal disease (ESDR) patients who met the study inclusion criteria in the Nephrology Department of Hunan Provincial People’s Hospital between December 2020 and June 2022 were included in this study. The baseline demographic, clinical and laboratory parameters were collected at the time of AVF creation and analyzed. Of the 233 ESRD patients, 146 (62.7%) were male and the mean age was 56.11 ± 12.14 (21–82) years. The patients were followed for a median time of 14 months. Kaplan–Meier analysis showed a 6-, 12- and 24-month post-placement survival of 87.1%, 82.8% and 80.7%, respectively. Univariate Cox regression analysis revealed weight (HR, 1.03; P = 0.03) as a predictor for the loss of vascular access functionality. In addition, multivariate Cox regression analysis further demonstrated that sex (HR, 3.41; P = 0.03), weight (HR 1.08; P < 0.01) and phosphorus level (HR: 3.03; P = 0.01) are independent risk factors for AVF dysfunction. AVF dysfunction is highly associated with several risk factors including weight, phosphorus level, and sex. Positive intervention strategies targeting these potential factors, such as weight loss or oral phosphate binders could improve the long-term success of AVF.
Global diagnosis of land–atmosphere coupling based on water isotopes
Authors: Yuan Ruiqiang , Li Fei , Ye Ruyu 
Published: December 2023

AbstractLand–atmosphere coupling (LAC) plays a significant role in weather and climate and is related to droughts and heatwaves. We propose a simple and efficient LAC diagnosis method based on the analysis of water isotopes in atmospheric water vapour and precipitation. Using the method, we identify the primary LAC hotspot regions of the globe and reveal the seasonality of LAC strength. We find that LAC strength exhibits a relationship with latitude. Low latitudes present stronger LAC strength and contribute more significantly to the overall LAC area compared to boreal middle and high latitudes. It's important to note that LAC primarily manifests in the troposphere and is detected in the lower stratosphere of low latitudes, with limited influence observed in the stratosphere. However, the impact of LAC is noticeable in the upper stratosphere in boreal middle and high latitudes. Moreover, the seasonality of LAC strength is pronounced. On a global scale, the season with the strongest LAC is boreal autumn in the Northern Hemisphere but boreal summer in the Southern Hemisphere. Notably, this pattern does not exhibit a seesaw effect between the two hemispheres. Our isotope-based LAC diagnosis method captures the major LAC hotspots found in previous work and validates the seasonality of LAC within these hotspots. This substantiates the reliability and effectiveness of our isotope-based approach.
Exogenously applied 5-aminolevulinic acid modulates growth, yield, and physiological parameters in lentil (Lens culinaris Medik.) under rain-fed and supplemental irrigation conditions
Authors: Mohammadi Hamid , Ezati Parviz , Hazrati Saeid , Ghorbanpour Mansour 
Published: December 2023

AbstractLentils are a significant source of plant protein and are cultivated across Asia, Europe, and North Africa. Plants are subjected to various environmental stresses, which can hinder growth, yield, and productivity. 5-aminolevulinic acid (ALA) is a compound that acts as a precursor in the biosynthesis of tetrapyrroles and can increase plant tolerance to different abiotic stressors. However, the effects of exogenously applied ALA on lentil growth, yield, and physiological parameters under rain-fed and supplemental irrigation conditions are not well-known. In this study, a split plot experiment was conducted to investigate the impact of ALA foliar application and supplemental irrigation on lentil (Lens culinaris Medik.). The experiment was designed based on a randomized complete block with three replications. The main plot included four levels of supplemental irrigation [(supplementary irrigation in the flowering and early seed-filling stages, supplementary irrigation in the flowering stage, supplementary irrigation in the early seed-filling along with rain-fed conditions (no irrigation)]. The subplot considered foliar application of ALA at varying levels [(0 (control), 50 and 100 ppm)]. The results showed that water regimes and foliar spray with ALA significantly (P ˂ 0.01) affected plant height, number of pods per plant, pod weight, number of seeds per pod and weight of 1000 seeds, biological yield, seed yield, and harvest index. The highest total chlorophyll content was observed in plants that were subjected to supplementary irrigation in flowering and early seed filling stages and foliar sprayed with 100 ppm ALA. The study also found that exogenous ALA improved drought tolerance in lentil plants under rain-fed conditions mainly by regulating antioxidant enzymes, which ultimately protected the cellular membranes against overproduction of H2O2. Furthermore, ALA application increased total carbohydrate contents at all supplemental irrigation levels, but the rate was higher in complementary irrigation conditions during flowering and early seed-filling stages. Malondialdehyde (MDA), H2O2, and proline contents were increased in field-grown plants under rain-fed conditions without exogenous ALA application. In conclusion, this study sheds light on the effects of ALA foliar spray and supplemental irrigation on lentil growth, yield, and physiological parameters. The findings suggest that exogenous ALA can improve plant tolerance to various abiotic stressors and enhance plant growth, yield, and physiological parameters.
Perampanel attenuates oxidative stress and pyroptosis following subarachnoid hemorrhage via the SIRT3/FOXO3α pathway
Authors: Yang Hongqiao , Ding Changgeng , Cheng Ming , Sheng Zhengwei , Chen Lei , Chen Junhui , Wang Yuhai 
Published: December 2023

AbstractSubarachnoid hemorrhage (SAH) occurs most commonly after rupture of an aneurysm, resulting in high disability and mortality due to the absence of effective therapy. Its subsequent stage, early brain injury (EBI), promotes the sustainable development of injury in the brain and ultimately leads to poor prognosis. As a new antiepileptic drug, the effect of perampanel on EBI after SAH is unknown. Pyroptosis, a process of inflammatory programmed cell death, has been confirmed in most studies to play a substantial role in aggravating SAH-post EBI. Similarly, oxidative stress is closely involved in neuronal pyroptosis and the pathophysiological mechanism of SAH-post EBI, leading to a devastating outcome for SAH patients. Nonetheless, no studies have been conducted to determine whether perampanel reduces pyroptosis and oxidative stress in the context of SAH-induced EBI. Rat SAH model via endovascular perforation was constructed in this study, to assess the neuroprotective effect of perampanel on SAH-post EBI, and to clarify the possible molecular mechanism. By means of the neurological score, brain edema detection, FJB staining, immunofluorescence, WB, ELISA, and ROS assay, we found that perampanel can improve neuroscores and reduce brain edema and neuronal degeneration at 24 h after SAH; we also found that perampanel reduced oxidative stress, neuronal pyroptosis, and inhibition of the SIRT3-FOXO3α pathway at 24 h after SAH. When 3-TYP, an inhibitor of SIRT3, was administered, the effects of perampanel on the SIRT3-FOXO3a pathway, antioxidant stress, and neuronal pyroptosis were reversed. Taken together, our data indicate that perampanel attenuates oxidative stress and pyroptosis following subarachnoid hemorrhage via the SIRT3/FOXO3α pathway. This study highlights the application value of perampanel in subarachnoid hemorrhage and lays a foundation for clinical research and later transformation of perampanel in SAH.
Hepatoprotective effects of aspirin on diethylnitrosamine-induced hepatocellular carcinoma in rats by reducing inflammation levels and PD-L1 expression
Authors: Wang Yikai , Wang Muqi , Liu Chenrui , Hao Miao , Wang Wenjun , Li Yaping , Shi Juanjuan , Zhang Xin , Dang Shuangsuo 
Published: December 2023

AbstractAspirin, as a widely used anti-inflammatory drug, has been shown to exert anti-cancer effects in a variety of cancers. PD-L1 is widely expressed in tumor cells and inhibits anti-tumor immunity. This study aims to clarify whether aspirin exerts its anti-hepatocellular carcinoma (HCC) effect by inhibiting PD-L1 expression. The rat model of HCC was established by drinking 0.01% diethylnitrosamine (DEN), and aspirin was given by gavage. The gross and blood biochemical indexes of rats were analyzed. CD4 and CD8 expression in liver tissues were investigated by immunohistochemistry. CCK8 assay was used to detect the inhibitory effect of aspirin on the proliferation of HCC cells. The regulatory effect of aspirin on PD-L1 expression was analyzed by western blot. As a result, the tumor number and liver weight ratio in the DEN + ASA group were lower than those in the DEN group (P = 0.006, P = 0.046). Compared with the DEN group, the expression of CD4 in the DEN + ASA group was significantly increased, while CD8 was decreased (all P < 0.01). Biochemical indexes showed that there were differences in all indexes between the DEN and control group (P < 0.05). The levels of DBIL, ALP, and TT in the DEN + ASA group were lower than those in the DEN group (P = 0.038, P = 0.042, P = 0.031). In the DEN group, there was an obvious fibrous capsule around the tumor, and the portal vein was dilated. The pathological changes were mild in the DEN + ASA group. Compared with the DEN group, the expression of PD-L1 in liver tissue of the DEN + ASA group was decreased (P = 0.0495). Cytological experiments further showed that aspirin could inhibit the proliferation and PD-L1 expression in Hep G2 and Hep 3B cells. In conclusion, aspirin can inhibit the proliferation of HCC cells and reduce tumor burden by reducing inflammation and targeting PD-L1.
Mathematical-based morphological classification of skin eruptions corresponding to the pathophysiological state of chronic spontaneous urticaria
Authors: Seirin-Lee Sungrim , Matsubara Daiki , Yanase Yuhki , Kunieda Takuma , Takahagi Shunsuke , Hide Michihiro 
Published: December 2023

AbstractBackgroundChronic spontaneous urticaria (CSU) is one of the most intractable human-specific skin diseases. However, as no experimental animal model exists, the mechanism underlying disease pathogenesis in vivo remains unclear, making the establishment of a curative treatment challenging.MethodsA novel approach combining mathematical modelling, in vitro experiments and clinical data analysis was used to infer the pathological state of CSU patients from geometric features of the skin eruptions.ResultsBased on our hierarchical mathematical modelling, the eruptions of CSU were classified into five categories, each with distinct histamine, basophils, mast cells and coagulation factors network signatures. The analysis of 105 real CSU patients with this classification by six individual dermatologists achieved 87.6% agreement. Furthermore, our network analysis revealed that the coagulation status likely determines boundary/area pattern of wheals, while the state of spontaneous histamine release from mast cells may contribute to the divergence of size and outline of the eruptions.ConclusionsOur multi-faceted approach was accurate in defining pathophysiological states of disease based on geometric features offering the potential to improve the accuracy of CSU diagnosis and better management of the disease in the clinic.
Localization of seismic waves with submarine fiber optics using polarization-only measurements
Authors: Costa Luis , Varughese Siddharth , Mertz Pierre , Kamalov Valey , Zhan Zhongwen 
Published: December 2023

AbstractMonitoring seismic activity on the ocean floor is a critical yet challenging task, largely due to the difficulties of physical deployment and maintenance of sensors in these remote areas. Optical fiber sensing techniques are well-suited for this task, given the presence of existing transoceanic telecommunication cables. However, current techniques capable of interrogating the entire length of transoceanic fibers are either incompatible with conventional telecommunication lasers or are limited in their ability to identify the position of the seismic wave. In this work, we propose and demonstrate a method to measure and localize seismic waves in transoceanic cables using only conventional polarization optics, by launching pulses of changing polarization. We demonstrate our technique by measuring and localizing seismic waves from a magnitude Mw 6.0 earthquake (Guerrero, Mexico) using a submarine cable connecting Los Angeles, California and Valparaiso, Chile. Our approach introduces a cost-effective and practical solution that can potentially increase the density of geophysical measurements in hard-to-reach regions, improving disaster preparedness and response, with minimal additional demands on existing infrastructure.
A MnO2 nanosheet-mediated CRISPR/Cas12a system for the detection of organophosphorus pesticides in environmental water
Authors: Yu Hao-Ming , Liang Guo-Xi , Wang Hui-Yi , Hang Xiao-Min , Wang Hong-Hong , Peng Jia-Xin , Wang Li 
Published: December 2023

A novel and simple fluorescence analysis method for OPs in ambient water has been implemented via nanosheet mediated CRISPR/Cas12a, achieving a detection limit of 0.135 ng mL−1 for DDVP.
“I Could Not Talk . . . She Did Everything . . . She's Now My Sister”: People With Aphasia's Perspectives on Friends Who Stuck Around
Authors: Archer Brent , Azios Jamie H. , Douglas Natalie F. , Strong Katie A. , Worrall Linda , Simmons-Mackie Nina 
Published: December 2023

Purpose:Aphasia may decrease the capacity to develop and maintain friendships. The aim of this study was to better understand the perspectives of people with aphasia on why some friendship bonds remain strong and some do not. Furthermore, we wanted to explore how age and aphasia severity shape views on friendship.Method:We interviewed 27 people with aphasia about their experiences of friendship before and after the onset of aphasia. We then used framework analysis and reflexive thematic analysis to interpret the interview data.Results:From the interviews, we created four major themes concerning how friend relationships had been impacted by aphasia: (a) Not all bonds have the same chance of surviving the onset of aphasia; (b) people with aphasia's closest friends took active steps to keep relationships strong; (c) if friends knew some basic information about aphasia, bonds would stay stronger; (d) positive affective aspects of friendship play an important role in keeping bonds strong. We also noted differences in friendship experiences that appeared to be influenced by age and aphasia severity of participants.Conclusions:Interview data provided actionable ideas including focusing on friends who are likely to be responsive to help with maintaining the friendship, providing them with strategies to keep the friendship active and communication meaningful, and acknowledging the positive impact that this will have on the friend recovering from aphasia. More research is needed to develop programs that empower people with aphasia to maintain their friendships.Supplemental Material:https://doi.org/10.23641/asha.24688671
The MEGARA view of outflows in LINERs
Authors: Hermosa Muñoz L. , Cazzoli S. , Márquez I. , Masegosa J. , Chamorro-Cazorla M. , Gil de Paz A. , Castillo-Morales Á. , Gallego J. , Carrasco E. , Iglesias-Páramo J. , García-Vargas M. L. , Gómez-Álvarez P. , Pascual S. , Pérez-Calpena A. , Cardiel N. 
Published: December 2023

Context.Feedback processes, in particular those driven by outflows, are believed to play a major role in galaxy evolution. Outflows are believed to be ubiquitous in all active galactic nuclei (AGNs), although their presence in low luminosity AGNs, in particular for Low-Ionisation Nuclear Emission line Regions (LINERs), has only started to be explored. Their properties (geometry, mass, and energetics) are still far from being properly characterised.Aims.The main goal is to use integral field spectroscopic data from the MEGARA instrument at the Gran Telescopio Canarias (GTC) to analyse a small sample of nine LINERs, candidates of hosting ionised gas outflows. We aim to study the main emission lines in the optical wavelength range to identify their properties and physical origin.Methods.We obtained data cubes in several bands at the lowest (R ∼ 6000) and highest (R ∼ 20 000) spectral resolution of MEGARA. We modelled and subtracted the stellar continuum to obtain the ionised gas contribution, and then fitted the emission lines to extract their kinematics (velocity and velocity dispersion). We identified outflows as a secondary component in the emission lines and obtained their main properties.Results.The primary component of the emission lines was typically associated with gas in the galactic disc. For some objects, there is an enhanced-σregion typically co-spatial with the secondary component. We associated it to turbulent gas produced due to the interaction with the outflows. We find signatures of outflows in six LINERs, with mass outflow rates ranging from 0.004 to 0.4M⊙yr−1and energy rates from ∼1038to ∼1040erg s−1. Their mean electronic density is 600 cm−3, extending to distances of ∼400 pc at an (absolute) velocity of ∼340 km s−1(on average). They tend to be compact and unresolved, although for some sources they are extended with a bubble-like morphology.Conclusions.Our results confirm the existence of outflows in the best LINER candidates identified using previous long-slit spectroscopic and imaging data. These outflows do not follow the scaling relations obtained for more luminous AGNs. For some objects we discuss jets as the main drivers of the outflows.