bluuebunny/crossref_metadata_2025_split huggingface dataset:
Diagnostic Delay and Disease Burden in Primary Aldosteronism: An International Patient Survey
Authors: Ananda Roshan A. , Gwini Stella May , Long Katrina M. , Lai Jordan H. , Chen Gang , Russell Grant M. , Stowasser Michael , Fuller Peter J. , Yang Jun 
Published: December 2023

BACKGROUND:
Primary aldosteronism (PA) is a common but underdiagnosed cause of hypertension. Many patients experience preventable end-organ injury due to delayed or missed diagnosis but data on the experience of patients are limited.

METHODS:
We evaluated the lived experience of PA and determines factors associated with diagnostic delay through an international anonymous online cross-sectional survey, codesigned by researchers and PA consumers. We distributed the survey through academic medical centers, Amazon Mechanical Turk, Twitter, PA patient advocacy groups, and hypertension support groups on Facebook between March 21 and June 5, 2022.

RESULTS:
Of 684 eligible respondents, 66.5% were women. Diagnostic delay (defined as ≥5 years between the diagnosis of hypertension and PA) was reported in 35.6%. Delay was more likely in women than in men (odds ratio, 1.55 [95% CI, 1.10–2.20]) and respondents with ≥3 comorbidities versus none (odds ratio, 1.77 [95% CI, 1.05–3.02]), ≥10 symptoms versus none (odds ratio, 2.73 [95% CI, 1.74–4.44]), and on ≥4 antihypertensive medications versus none (odds ratio, 18.23 [95% CI, 6.24–77.72]). Three-quarters of patients (74.4%) experienced reduced symptom burden following targeted PA treatment. Quality of life improved in 62.3% of patients, and greater improvement was associated with being a woman (odds ratio, 1.42, [95% CI, 1.02–1.97]), receiving adrenalectomy (odds ratio, 2.36 [95% CI, 1.67–3.35]), and taking fewer antihypertensive medications following diagnosis (odds ratio, 5.28 [95% CI, 3.55–7.90]).

CONCLUSIONS:
One-third of patients with PA experienced prolonged diagnostic delays. Targeted treatment led to reduced symptom burden and improved quality of life. Gender differences in diagnostic delay and symptom burden are prominent. These findings suggest that routine screening for PA at the onset of hypertension may reduce diagnostic delay and facilitate timely diagnosis.
“If the Kingdom be Ruled According to the Tao”: Politics as “Eastern Wisdom” in Aleister Crowley’s Reception of the Daodejing
Authors: Nilsson Johan 
Published: December 2023

Abstract
The fascination with the “Eastern Wisdom” exhibited among esoteric movements in the late nineteenth and early twentieth century is often understood as an interest in spirituality. Existing research has focused on how these movements took an interest in beliefs in doctrines like karma and reincarnation, as well as in practices of meditation and divination. Although this characterization is broadly correct, it is not the whole picture. This article explores a case where “Eastern Wisdom” was instead conceived in a way that explicitly included politics: Aleister Crowley’s interpretation of the instructions for government given in the Daodejing. During the early twentieth century the Daodejing was the focus of broad interest by sinologists, artists, and esoteric writers alike, among them Crowley. Although intensely engaged in divination and esoteric ritual practices, Crowley was also a utopian political thinker who wanted to see radical societal reform in line with his religious and political ideals. The article explores Crowley’s interpretation of the political aspects of the Daodejing and how he strove to interpret them in light of his own religious beliefs. It suggests that, far from being exclusively private and individualistic, the esoteric understanding of “Eastern Wisdom” could include elements like political theory and utopian thinking.
The Penumbra of the Great Tang: Poetry from the Margins of the Empire at the Turn of the Eighth Century
Authors: Tian Xiaofei 
Published: December 2023

Abstract
The turn of the eighth century witnessed, for the first time in Chinese history, a concentration of poems written by exiled courtiers. In an era when mobility was limited by curfews, passes, and vehicular technologies, banishment to faraway places, accomplished by a decreed use of exclusionary post-station horses, ironically became a sanctioned and expedited means of traversing new territories. Through the poetic texts circulated via the highly developed post-station system, the empire’s center in the north became more connected to its distant margins than ever before. This article argues that these poems, characterized by centripetalism and constituting a petitionary genre, contributed to a new way of envisioning the empire as a whole and in its totality, and if we define “court” as a field of dynamic power relations, then these poems are court poetry, whose definition must be expanded to reflect the catholic nature of the term “court” itself.
The Quanzhou Qianfo xinzhu zhuzushi song (Or.8210/S.1635): Manuscript, Textual History, and Genealogy
Authors: Van Cutsem Laurent 
Published: December 2023

Abstract
This article explores the textual history and genealogical claims in the Quanzhou Qianfo xinzhu zhuzushi song 泉州千佛新著諸祖師頌 (Or.8210/S.1635), a collection of encomia composed by Wendeng 文僜 (d. 972) that documents the formation of the so-called “southern” Chan lineage and provides a crucial link between the Baolin zhuan 寶林傳 and the Zutang ji 祖堂集. The focus of this paper is on reexamining the potentially layered nature of Wendeng’s work based on the preface by Huiguan 慧觀 (d.u.), internal evidence from the Dunhuang manuscript, and related accounts in Chan records and local gazetteers. In addition, this study investigates the genealogical glosses in S.1635 and suggests that these were probably not authored by Wendeng and therefore cannot be taken as evidence of his understanding of the pedigree of the presumed successors to Huineng 慧能 (638–713).
A Double-Edged Sword: Examining the Structures That Afford and Limit Practices of Environmental Learning and Community Building in an Urban Community Garden in South Korea
Authors: Ahn Saerom , Gi Gyeongmi , Martin Sonya N. 
Published: December 2023

Abstract
Community gardens offer valuable educational and social benefits, contributing to enhanced environmental learning and community building. To expand these opportunities and support community gardens’ objectives, we emphasize the necessity of establishing specific structures that facilitate gardeners’ practices. Investigating a Korean community as a case study, we identify the ways in which certain structures afford and limit learning opportunities and community building, shedding light on the role structures can play in the field of the community garden. Our analysis illustrates the importance of understanding the dynamic relationship between gardening practices and supporting structures. By doing so, garden participants and policymakers can more intentionally activate opportunities to learn about the environment and to build community. Our research aims to examine structures that afford and limit practices as a means of providing a valuable lens to guide community gardening program designers and policymakers in achieving the goals of promoting environmental learning and community building.
Indoors vs. Outdoors
Authors: Jablonski Simone 
Published: December 2023

Abstract
Modelling activities serve to integrate real-life objects into STEM classes. This article investigates different settings for modelling with real objects and their representations both inside and outside the classroom. Using the example of mathematics, the settings working outside the classroom at the real object, inside the classroom with photos, and inside the classroom with a 3D model are considered and compared in an explorative study with 29 students. Questionnaire items provide information about the students’ perceptions of the different settings. The results report significant differences in the simplifying and structuring step as well as in the mathematising step when comparing the settings outside and inside with photos. The results are taken up for generating hypotheses concerning the role of the outdoors in interdisciplinary STEM modelling activities.
STEAM Trails in Outdoor Learning Environments around the Egyptian Pyramids Complex
Authors: El Bedewy Shereen , Lavicza Zsolt , Haas Ben , Kreis Yves 
Published: December 2023

Abstract
During the last years, the arrival of new technologies facilitated STEAM integration in real-world learning situations, e.g., GPS-based software and mixed realities allow us to combine the virtual and real world to increase our understanding of complex knowledge. Based on these technologies, the authors designed several teaching practices by creating STEAM trails in an outdoor learning environment, integrating architecture in place-based learning approaches that are likely to occur with architecture connected to arts, culture, history and mathematics. However, the complexity of STEAM-integrated teacher practices within real-world situations is challenging. In this conceptual article, the authors will present and discuss the designed teaching practices, stress possible hindrances and chances for their integration into teaching and discuss further research opportunities. This study may be of interest to educators, curriculum developers and policy makers to promote outdoor teaching practices in integrated STEAM trails.
Development of a Large-Scale Pathogen Screening Test for the Biosafety Evaluation of Canine Mesenchymal Stem Cells
Authors: Pekker Emese , Priskin Katalin , Szabó-Kriston Éva , Csányi Bernadett , Buzás-Bereczki Orsolya , Adorján Lili , Szukacsov Valéria , Pintér Lajos , Rusvai Miklós , Cooper Paul , Kiss-Tóth Endre , Haracska Lajos 
Published: December 2023

Abstract
Background
The action of mesenchymal stem cells (MSCs) is the subject of intense research in the field of regenerative medicine, including their potential use in companion animals, such as dogs. To ensure the safety of canine MSC batches for their application in regenerative medicine, a quality control test must be conducted in accordance with Good Manufacturing Practices (GMP). Based on guidance provided by the European Medicines Agency, this study aimed to develop and validate a highly sensitive and robust, nucleic acid-based test panel for the detection of various canine pathogens. Analytical sensitivity, specificity, amplification efficiency, and linearity were evaluated to ensure robust assessment. Additionally, viable spike-in controls were used to control for optimal nucleic acid extraction. The conventional PCR-based and real-time PCR-based pathogen assays were evaluated in a real-life setting, by direct testing MSC batches.

Results
The established nucleic acid-based assays displayed remarkable sensitivity, detecting 100–1 copies/reaction of template DNA. They also exhibited high specificity and efficiency. Moreover, highly effective nucleic acid isolation was confirmed by the sensitive detection of spike-in controls. The detection capacity of our optimized and validated methods was determined by direct pathogen testing of nine MSC batches that displayed unusual phenotypes, such as reduced cell division or other deviating characteristics. Among these MCS batches of uncertain purity, only one tested negative for all pathogens. The direct testing of these samples yielded positive results for important canine pathogens, including tick-borne disease-associated species and viral members of the canine infectious respiratory disease complex (CIRDC). Notably, samples positive for the etiological agents responsible for enteritis (CPV), leptospirosis (Leptospira interrogans), and neosporosis (Neospora caninum) were also identified. Furthermore, we conducted biosafety evaluation of 12 MSC batches intended for therapeutic application. Eleven MSC batches were found to be free of extraneous agents, and only one tested positive for a specific pathogen, namely, canine parvovirus.

Conclusion
In this study, we established and validated reliable, highly sensitive, and accurate nucleic acid-based testing methods for a broad spectrum of canine pathogens.
Draft genome of Castanopsis chinensis, a dominant species safeguarding biodiversity in subtropical broadleaved evergreen forests
Authors: Chen Pan , Lian Ju-Yu , Wu Bin , Cao Hong-Lin , Li Zhi-Hong , Wang Zheng-Feng 
Published: December 2023

AbstractObjectivesCastanopsisis the third largest genus in the Fagaceae family and is essentially tropical or subtropical in origin. The species in this genus are mainly canopy-dominant trees, and the key components of evergreen broadleaved forests play a crucial role in the maintenance of local biodiversity.Castanopsis chinensis, distributed from South China to Vietnam, is a representative species. It currently suffers from a high disturbance of human activity and climate change. Here, we present its assembled genome to facilitate its preliminary conservation and breeding on the genome level.Data descriptionTheC.chinensisgenome was assembled and annotated by Nanopore and MGI whole-genome sequencing and RNA-seq reads using leaf tissues. The assembly was 888,699,661 bp in length, consisting of 133 contigs and a contig N50 of 23,395,510 bp. A completeness assessment of the assembly with Benchmarking Universal Single-Copy Orthologs (BUSCO) indicated a score of 98.3%. Repetitive elements comprised 471,006,885 bp, accounting for 55.9% of the assembled sequences. A total of 51,406 genes that coded for 54,310 proteins were predicted. Multiple databases were used to functionally annotate the protein sequences.
Association of serum Asprosin concentrations with heart failure
Authors: Wang Guoan , Fan Chunzhen , Chai Yaru , Yu Xin , Xing Mingqing , Lv Zhihua , Yuan Shanshan , Dai Hongyan 
Published: December 2023

Abstract
Background
To analyze the association of serum Asprosin concentrations with heart failure (HF).

Methods
A total of 103 patients with HF were included in the HF group, and 103 patients with health checkups were included in the non-HF group. The serum Asprosin levels of the two groups were measured, and relevant clinical data were collected for statistical analysis.

Results
Compared with the non-HF group, the serum Asprosin concentration was significantly higher in the HF group, and the difference was statistically significant (P < 0.001). According to the serum Asprosin levels, we divided all the subjects into three quartiles. We found that the prevalence of HF increased with increasing serum Asprosin levels in the three groups (P < 0.001). Serum Asprosin levels were positively correlated with NT-ProBNP (P < 0.05) and negatively correlated with LVEF (P < 0.001). Dichotomous logistic regression analysis found Asprosin and age to be independent risk factors for HF (OR = 1.010, 95% CI: 1.003–1.018; OR = 1.058, 95% CI:1.004–1.665, respectively). Combining Asprosin and NT-proBNP indicators to draw ROC curves can improve the specificity and sensitivity of HF diagnosis.

Conclusions
Serum Asprosin levels were significantly elevated in HF patients. The serum Asprosin level is an independent risk factor for HF, and the combined detection of Asprosin and NT-proBNP levels can improve the accuracy of HF diagnosis.
Expanded nursing roles to promote person-centred care for people with cognitive impairment in acute care (ENROLE-acute): study protocol for a controlled clinical trial, process and economic evaluation
Authors: von der Lühe Verena , Roos Marcelina , Löbberding Mareike , Scholten Nadine , Müller Wiebke , Hellmich Martin , Simic Dusan , Köpke Sascha , Dichter Martin N. 
Published: December 2023

Abstract
Background
For people with cognitive impairment, hospitalisation is challenging and associated with adverse events as well as negative outcomes resulting in a prolonged hospital stay. Person-centred care can improve the quality of care and the experience of people with cognitive impairment during hospitalisation. However, current care processes in German hospitals are rarely person-centred. To enable successful implementation of person-centred care on hospital wards, change agents within the interprofessional team are key. The aim of this study is to test the feasibility and initial effects of a newly developed complex person-centred care intervention for people with cognitive impairment provided by expanded practice nurses in acute care.

Methods
We will conduct an exploratory non-randomised controlled clinical trial with accompanying process and cost evaluation with three intervention and three control wards at one university hospital. The person-centred care intervention consists of 14 components reflecting the activities of expanded practice nurses within the interprofessional team on the intervention wards. The intervention will be implemented over a six-month period and compared with optimised care on the control wards. We will include people aged 65 years and older with existing cognitive impairment and/or at risk of delirium. The estimated sample size is 720 participants. The primary outcome is length of hospital stay. Secondary outcomes include prevalence of delirium, prevalence of agitation, sleep quality, and person-centred care. We will collect patient level data at six time points (t1 admission, t2 day 3, t3 day 7, t4 day 14, t5 discharge, t6 30 days after discharge). For secondary outcomes at staff level, we will collect data before and after the intervention period. The process evaluation will examine degree and quality of implementation, mechanisms of change, and the context of the complex intervention. The economic evaluation will focus on costs from the hospital’s perspective.

Discussion
The ENROLE-acute study will provide insights into the effectiveness and underlying processes of a person-centred care intervention for people with cognitive impairment provided by expanded practice nurses on acute hospitals wards. Results may contribute to intervention refinement and evidence-based decision making.

Trial registration
Current controlled trials: ISRCTN81391868. Date of registration: 12/06/2023. URL: https://doi.org/10.1186/ISRCTN81391868
Equipping undergraduate medical and nursing students with elderly health care assessment skills at Makerere University, College of Health Sciences, Uganda
Authors: Nakasujja Noeline , Nawagi Faith , Aujo Blessed Tabitha , Ajambo Aidah 
Published: December 2023

Abstract
Background
Elderly health care training and aging science remain the least prioritized discipline of medical education in many African countries. With scant scientific evidence on elderly health care in low-income countries, coupled with limited exposure to elderly health care training, this project aimed to equip undergraduate health professional students with elderly health care assessment skills and research through an online course and a clinical placement.

Methods
Students (3rd year) underwent online elderly health care training through the Alison courses published by the Advanced Learning Academy in Ireland. The students were then subjected to an online exam with a pass mark of 80%. Students were also trained on standard elderly health care assessment tools through a one-day session. For practical skills on data collection, each student assessed 15 elderly patients at the Mulago National Referral Hospital Assessment Centre. All tools once filled in were assessed for completion. A one-day reflection session was held with students, faculty and the project leads to share findings from the various tools used to assess elderly individuals. The students shared their experiences and provided feedback on the online training as well as the hardships they may have experienced while administering the tools. A certificate of participation was provided to the students at the end of the project.

Results
All the students (10) gained knowledge on elderly assessment skills, the impact of aging on various body systems, and how to manage common occurrences among elderly individuals. The average score in the post-exam was 82% (standard deviation ± 2.01). All students (10) reported having had this as their first training on the assessment of functionality among elderly individuals.

Conclusions
The students gained knowledge of elderly health assessments as well as the impact of aging on various body systems. They also gained insight into how to care for the elderly holistically with an added understanding of how to manage spinal and traumatic brain injuries.
Effectiveness evaluation of autotransplanted teeth after performing extraoral endodontic surgery instead of conventional root canal therapy
Authors: Liao Fenglin , Wang Hui , Zhao Jihong , Zhang Biao , Zhong Haoyan 
Published: December 2023

Abstract
Purpose
The aim of this study was to examine the viability and efficacy of utilizing extraoral apicoectomy and retrograde filling in combination to seal the root canal system of mature molars without the need for root canal therapy (RCT) during the autotransplantation of teeth (ATT).

Materials and methods
This study screened 27 patients who received ATT at the Department of Oral Surgery in the Hospital of Stomatology from 2019 to 2021. Extraoral apicoectomy and retrograde filling were performed, while RCT was temporarily not performed. The study analysed the periodontal status and masticatory function of transplanted teeth one to three years postoperation and used cone-beam computed tomography (CBCT) and periapical radiograph (PA) to evaluate the integrity of the periodontal space and intra/periapical inflammation. The potential predictors of survival/success were analysed statistically. We also conducted questionnaires and chewing efficiency tests.

Results
In this study, 27 TTs from 27 patients were found to be fully functional in terms of chewing ability. The overall survival rate was 100% (27/27), and the success rate was 70.4% (19/27). A total of 90.9% (20/22) of patients reported being satisfied or very satisfied with their TTs. Additionally, the chewing efficiency of the transplantation side was on average 82.0% of that of the healthy side, with a significant difference between the two sides (P < 0.05). None of the potential predictors were found to significantly affect the success or survival of the transplanted tooth (TT).

Conclusion
The combination of extraoral apicoectomy and retrograde filling in TT showed promising outcomes, but further clinical cases and longer follow-up times are still required to validate the treatment plan.