bluuebunny/crossref_metadata_2025_split huggingface dataset:
Resisting Biographical Illusions: Pandurang Khankhoje, Indian Revolutionaries and the Anxiety to be Remembered
Authors: Cháirez-Garza Jesús F. 
Published: January 2024

AbstractRecently, there has been a growing discussion concerning the way historians should approach the study of Indian revolutionaries both within and outside the subcontinent. Described as ‘the revolutionary turn’, this area of research has not only explored the porosity and ambiguity in defining individuals as revolutionaries but has also questioned the way such revolutionaries sought to write themselves into history as a political act. Continuing this line of interrogation, this article examines the retrospective political claims of heroic revolutionary belonging by analysing the autobiographical notes left by Pandurang Khankhoje, a peripatetic Indian who left his country pursuing dreams of revolution. While in the last decade Khankhoje has become an iconic character in writing histories about global solidarities and anti-colonial resistance, this article asks to what extent can historians believe self-described revolutionary narratives. As this article shows, these narratives privilege what Pierre Bourdieu has called ‘biographical illusion’, the organisation of life as a history that unfolds coherently and chronologically from beginning to end. Political or ideological differences and inconsistencies are flattened in the name of global ideologies or solidarities. As an attempt to disrupt these narratives, this article will focus on the silences, absences and ‘unreliability’ of the experiences and sources used to understand the work and lives of Indian revolutionaries abroad, such as Khankhoje, Lala Har Dayal and M. N. Roy. This article argues that the story of revolutionaries reveals important details about how they understood the racial, political and gender structures of different societies in the early twentieth century.
Leaky-wave antenna on substrate-integrated waveguide with radiation pattern controlled by DC voltage
Authors: Machac Jan , Svanda Milan , Kabourek Vaclav 
Published: January 2024

AbstractThis paper presents the application of a substrate-integrated waveguide (SIW) for the design of a leaky-wave antenna (LWA). The antenna radiates through a wide slot in the top wall of the SIW structure in the forward direction. The effective width of the slot is varied by changing capacitances of two arrays of varactors connected between slot edges and inserted conducting strips. The radiation pattern of the antenna is by this way controlled by DC bias, which sets the capacitances of varactors. The maximum radiation direction in elevation can be varied within 35° by changing the DC bias from 2 to 12 V. This elevation angle is measured from the broad side direction perpendicular to the antenna substrate. The measured antenna characteristics are in accord with those predicted by simulation. The antenna can be simply fabricated by a planar circuit board technology.
Combining soft robotics and telerehabilitation for improving motor function after stroke
Authors: Proietti Tommaso , Nuckols Kristin , Grupper Jesse , Schwerz de Lucena Diogo , Inirio Bianca , Porazinski Kelley , Wagner Diana , Cole Tazzy , Glover Christina , Mendelowitz Sarah , Herman Maxwell , Breen Joan , Lin David , Walsh Conor 
Published: January 2024

Abstract
Telerehabilitation and robotics, either traditional rigid or soft, have been extensively studied and used to improve hand functionality after a stroke. However, a limited number of devices combined these two technologies to such a level of maturity that was possible to use them at the patients’ home, unsupervised. Here we present a novel investigation that demonstrates the feasibility of a system that integrates a soft inflatable robotic glove, a cloud-connected software interface, and a telerehabilitation therapy. Ten chronic moderate-to-severe stroke survivors independently used the system at their home for 4 weeks, following a software-led therapy and being in touch with occupational therapists. Data from the therapy, including automatic assessments by the robot, were available to the occupational therapists in real-time, thanks to the cloud-connected capability of the system. The participants used the system intensively (about five times more movements per session than the standard care) for a total of more than 8 hr of therapy on average. We were able to observe improvements in standard clinical metrics (FMA +3.9 ± 4.0, p < .05, COPM-P + 2.5 ± 1.3, p < .05, COPM-S + 2.6 ± 1.9, p < .05, MAL-AOU +6.6 ± 6.5, p < .05) and range of motion (+88%) at the end of the intervention. Despite being small, these improvements sustained at follow-up, 2 weeks after the end of the therapy. These promising results pave the way toward further investigation for the deployment of combined soft robotic/telerehabilitive systems at-home for autonomous usage for stroke rehabilitation.
Incentivizing Responses in International Organization Elite Surveys: Evidence from the World Bank
Authors: Heinzel Mirko , Weaver Catherine , Briggs Ryan 
Published: January 2024

AbstractScholars of International Organizations (IOs) increasingly use elite surveys to study the preferences and decisions of policymakers. When designing these surveys, one central concern is low statistical power, because respondents are typically recruited from a small and inaccessible population. However, much of what we know about how to incentivize elites to participate in surveys is based on anecdotal reflections, rather than systematic evidence on which incentives work best. In this article, we study the efficacy of three incentives in a preregistered experiment with World Bank staff. These incentives were the chance to win an Amazon voucher, a donation made to a relevant charity, and a promise to provide a detailed report on the findings. We find that no incentive outperformed the control group, and the monetary incentive decreased the number of respondents on average by one-third compared to the control group (from around 8% to around 5%).
Noise and mental health: evidence, mechanisms, and consequences
Authors: Hahad Omar , Kuntic Marin , Al-Kindi Sadeer , Kuntic Ivana , Gilan Donya , Petrowski Katja , Daiber Andreas , Münzel Thomas 
Published: January 2024

AbstractThe recognition of noise exposure as a prominent environmental determinant of public health has grown substantially. While recent years have yielded a wealth of evidence linking environmental noise exposure primarily to cardiovascular ailments, our understanding of the detrimental effects of noise on the brain and mental health outcomes remains limited. Despite being a nascent research area, an increasing body of compelling research and conclusive findings confirms that exposure to noise, particularly from sources such as traffic, can potentially impact the central nervous system. These harms of noise increase the susceptibility to mental health conditions such as depression, anxiety, suicide, and behavioral problems in children and adolescents. From a mechanistic perspective, several investigations propose direct adverse phenotypic changes in brain tissue by noise (e.g. neuroinflammation, cerebral oxidative stress), in addition to feedback signaling by remote organ damage, dysregulated immune cells, and impaired circadian rhythms, which may collectively contribute to noise-dependent impairment of mental health. This concise review linking noise exposure to mental health outcomes seeks to fill research gaps by assessing current findings from studies involving both humans and animals.
Treatment-free remission after a second TKI discontinuation attempt in patients with Chronic Myeloid Leukemia re-treated with dasatinib – interim results from the DAstop2 trial
Authors: Flygt Hjalmar , Söderlund Stina , Richter Johan , Saussele Susanne , Koskenvesa Perttu , Stenke Leif , Mustjoki Satu , Dimitrijevic Andreja , Stentoft Jesper , Majeed Waleed , Roy Lydia , Wolf Dominik , Dreimane Arta , Gjertsen Bjørn Tore , Gedde-Dahl Tobias , Ahlstrand Erik , Markevärn Berit , Hjorth-Hansen Henrik , Janssen Jeroen , Olsson-Strömberg Ulla 
Published: January 2024

AbstractTyrosine kinase inhibitor (TKI) discontinuation in chronic myeloid leukemia (CML) has become part of routine care for patients with a sustained deep molecular response (DMR). Approximately 50% experience a molecular relapse upon TKI cessation. Most of them quickly regain DMR upon TKI resumption. Whether these patients can achieve a second treatment-free remission (TFR) remains unclear. DAstop2 (ClinicalTrials.gov ID: NCT03573596) is a prospective study including patients with a failed first TFR attempt re-treated with any TKI for ≥ one year. Upon entering the study, patients received the TKI dasatinib for additional two years. Patients with sustained DMR for ≥1 year qualified for a second TKI stop. Ninety-four patients were included between Oct 2017-Dec 2021. At the time of data analysis, 62 patients had attempted a 2nd stop. After a median follow-up of 27 months from 2nd stop, TFR rates were 61, 56 and 46% at 6, 12 and 24 months respectively. No progression to advanced stage disease was seen and 87% had re-achieved MR4 within a median of 3 months from TKI re-initiation. In summary, we show that a 2nd TFR attempt after dasatinib treatment is safe, feasible and TFR rates seem in the range of those reported in trials of a first TKI stop.
Porous nanocomposites with enhanced intrinsic piezoresistive sensitivity for bioinspired multimodal tactile sensors
Authors: Zhang Jianpeng , Wei Song , Liu Caichao , Shang Chao , He Zhaoqiang , Duan Yu , Peng Zhengchun 
Published: January 2024

AbstractIn this work, we propose porous fluororubber/thermoplastic urethane nanocomposites (PFTNs) and explore their intrinsic piezoresistive sensitivity to pressure. Our experiments reveal that the intrinsic sensitivity of the PFTN-based sensor to pressure up to 10 kPa increases up to 900% compared to the porous thermoplastic urethane nanocomposite (PTN) counterpart and up to 275% compared to the porous fluororubber nanocomposite (PFN) counterpart. For pressures exceeding 10 kPa, the resistance-pressure relationship of PFTN follows a logarithmic function, and the sensitivity is 221% and 125% higher than that of PTN and PFN, respectively. With the excellent intrinsic sensitivity of the thick PFTN film, a single sensing unit with integrated electrode design can imitate human skin for touch detection, pressure perception and traction sensation. The sensing range of our multimodal tactile sensor reaches ~150 Pa, and it exhibits a linear fit over 97% for both normal pressure and shear force. We also demonstrate that an electronic skin, made of an array of sensing units, is capable of accurately recognizing complex tactile interactions including pinch, spread, and tweak motions.
EEG-vigilance regulation is associated with and predicts ketamine response in major depressive disorder
Authors: Ip Cheng-Teng , de Bardeci Mateo , Kronenberg Golo , Pinborg Lars Hageman , Seifritz Erich , Brunovsky Martin , Olbrich Sebastian 
Published: January 2024

AbstractKetamine offers promising new therapeutic options for difficult-to-treat depression. The efficacy of treatment response, including ketamine, has been intricately linked to EEG measures of vigilance. This research investigated the interplay between intravenous ketamine and alterations in brain arousal, quantified through EEG vigilance assessments in two distinct cohorts of depressed patients (original dataset: n = 24; testing dataset: n = 24). Clinical response was defined as a decrease from baseline of >33% on the Montgomery–Åsberg Depression Rating Scale (MADRS) 24 h after infusion. EEG recordings were obtained pre-, start-, end- and 24 h post- infusion, and the resting EEG was automatically scored using the Vigilance Algorithm Leipzig (VIGALL). Relative to placebo (sodium chloride 0.9%), ketamine increased the amount of low-vigilance stage B1 at end-infusion. This increase in B1 was positively related to serum concentrations of ketamine, but not to norketamine, and was independent of clinical response. In contrast, treatment responders showed a distinct EEG pattern characterized by a decrease in high-vigilance stage A1 and an increase in low-vigilance B2/3, regardless of whether placebo or ketamine had been given. Furthermore, pretreatment EEG differed between responders and non-responders with responders showing a higher percentage of stage A1 (53% vs. 21%). The logistic regression fitted on the percent of A1 stages was able to predict treatment outcomes in the testing dataset with an area under the ROC curve of 0.7. Ketamine affects EEG vigilance in a distinct pattern observed only in responders. Consequently, the percentage of pretreatment stage A1 shows significant potential as a predictive biomarker of treatment response.Clinical Trials Registration:https://www.clinicaltrialsregister.eu/ctr-search/trial/2013-000952-17/CZRegistration number: EudraCT Number: 2013-000952-17.
Farnesyl-transferase inhibitors show synergistic anticancer effects in combination with novel KRAS-G12C inhibitors
Authors: Baranyi Marcell , Molnár Eszter , Hegedűs Luca , Gábriel Zsófia , Petényi Flóra Gréta , Bordás Fanni , Léner Violetta , Ranđelović Ivan , Cserepes Mihály , Tóvári József , Hegedűs Balázs , Tímár József 
Published: January 2024

Abstract
Background
Inhibition of mutant KRAS challenged cancer research for decades. Recently, allele-specific inhibitors were approved for the treatment of KRAS-G12C mutant lung cancer. However, de novo and acquired resistance limit their efficacy and several combinations are in clinical development. Our study shows the potential of combining G12C inhibitors with farnesyl-transferase inhibitors.

Methods
Combinations of clinically approved farnesyl-transferase inhibitors and KRAS G12C inhibitors are tested on human lung, colorectal and pancreatic adenocarcinoma cells in vitro in 2D, 3D and subcutaneous xenograft models of lung adenocarcinoma. Treatment effects on migration, proliferation, apoptosis, farnesylation and RAS signaling were measured by histopathological analyses, videomicroscopy, cell cycle analyses, immunoblot, immunofluorescence and RAS pulldown.

Results
Combination of tipifarnib with sotorasib shows synergistic inhibitory effects on lung adenocarcinoma cells in vitro in 2D and 3D. Mechanistically, we present antiproliferative effect of the combination and interference with compensatory HRAS activation and RHEB and lamin farnesylation. Enhanced efficacy of sotorasib in combination with tipifarnib is recapitulated in the subcutaneous xenograft model of lung adenocarcinoma. Finally, combination of additional KRAS G1C and farnesyl-transferase inhibitors also shows synergism in lung, colorectal and pancreatic adenocarcinoma cellular models.

Discussion
Our findings warrant the clinical exploration of KRAS-G12C inhibitors in combination with farnesyl-transferase inhibitors.
Caspase-dependent apoptosis in Riboflavin Transporter Deficiency iPSCs and derived motor neurons
Authors: Marioli Chiara , Muzzi Maurizio , Colasuonno Fiorella , Fiorucci Cristian , Cicolani Nicolò , Petrini Stefania , Bertini Enrico , Tartaglia Marco , Compagnucci Claudia , Moreno Sandra 
Published: January 2024

AbstractRiboflavin Transporter Deficiency (RTD) is a rare genetic, childhood-onset disease. This pathology has a relevant neurological involvement, being characterized by motor symptoms, ponto-bulbar paralysis and sensorineural deafness. Such clinical presentation is associated with muscle weakness and motor neuron (MN) degeneration, so that RTD is considered part of the MN disease spectrum. Based on previous findings demonstrating energy dysmetabolism and mitochondrial impairment in RTD induced Pluripotent Stem cells (iPSCs) and iPSC-derived MNs, here we address the involvement of intrinsic apoptotic pathways in disease pathogenesis using these patient-specific in vitro models by combined ultrastructural and confocal analyses. We show impaired neuronal survival of RTD iPSCs and MNs. Focused Ion Beam/Scanning Electron Microscopy (FIB/SEM) documents severe alterations in patients’ cells, including deranged mitochondrial ultrastructure, and altered plasma membrane and nuclear organization. Occurrence of aberrantly activated apoptosis is confirmed by immunofluorescence and TUNEL assays. Overall, our work provides evidence of a role played by mitochondrial dysfunction in RTD, and identifies neuronal apoptosis as a contributing event in disease pathogenesis, indicating intrinsic apoptosis pathways as possible relevant targets for more effective therapeutical approaches.
Glial senescence enhances α-synuclein pathology owing to its insufficient clearance caused by autophagy dysfunction
Authors: Hong Bin , Ohtake Yosuke , Itokazu Takahide , Yamashita Toshihide 
Published: January 2024

AbstractParkinson’s disease (PD) is characterized by the pathological accumulation of α-synuclein (α-syn) and loss of dopaminergic neurons in the substantia nigra. Aging is a significant risk factor for PD. The accumulation of senescent glial cells in the aged brain contributes to PD progression by inducing chronic neuroinflammatory processes. However, although the insufficient degradation of α-syn aggregates results in PD deterioration, the possible alteration in the ability of α-syn clearance in senescent glia has received little attention. In this study, we investigated how aging and glial senescence affect the capacity of α-syn clearance. We found that following the intra-striatal injection of human α-syn (hu-α-syn) preformed fibril, hu-α-syn pathology persisted more in aged mice compared with younger mice and that aged microglia exhibited greater accumulation of hu-α-syn than younger microglia. Moreover, in vitro assay revealed that the clearance of hu-α-syn was primarily dependent on the autophagy-lysosome system rather than on the ubiquitin-proteasome system and that the capacity of hu-α-syn clearance was diminished in senescent glia because of autophagy-lysosome system dysfunction. Overall, this study provides new insights into the role of senescent glia in PD pathogenesis.
Phosphorylated α-synuclein deposited in Schwann cells interacting with TLR2 mediates cell damage and induces Parkinson’s disease autonomic dysfunction
Authors: Li Yangxia , Tong Qing , Wang Ye , Cheng Yue , Geng Yao , Tian Tian , Yuan Yongsheng , Fan Yi , Lu Ming , Zhang Kezhong 
Published: January 2024

AbstractDespite the significant frequency of autonomic dysfunction (AutD) in Parkinson’s disease (PD) patients, its pathogenesis and diagnosis are challenging. Here, we aimed to further explore the mechanism of phosphorylated α-synuclein (p-α-syn) deposited in vagus nerve Schwann cells (SCs) causing SCs damage and PD AutD. 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP, 20 mg/kg) was administrated to C57BL/6 mice twice a week for 35 days. Following the final injection, locomotor functions, gastrointestinal symptoms, urine functions, and cardiovascular system functions were evaluated. Meanwhile, we examined p-α-syn deposited in vagus nerve SCs, Toll-like receptor 2 (TLR2) activation, and SCs loss using immunofluorescence, western blot, and Luxol fast blue staining. In vitro, the rat SCs line RSC96 cells were exposed to α-synuclein preformed fibril (α-syn PFF), and cell viability was detected by CCK8. Co-IP was used to identify the interaction between p-α-syn and TLR2. Furthermore, the role of TLR2 in p-α-syn-mediated SCs damage was confirmed by the administration of CU-CPT22, a specific blocker of TLR2. In vivo, apart from dyskinesia, MPTP mice exhibited constipation, urinary dysfunction, and cardiovascular failure, which were associated with the deposition of p-α-syn in vagus nerve SCs, TLR2 activation, and vagus nerve demyelination. In vitro, stimulation of α-syn PFF induced a time-dependent loss of viability, and p-α-syn deposited in RSC96 cells induced a cellular inflammatory response by interacting with TLR2, resulting in cell dysfunction and apoptosis. However, both SCs inflammatory response and cell viability were alleviated after inhibition of TLR2. Furthermore, 1 h fecal pellets and water content, the frequency of 1 h urine, blood pressure, heart rate, and heart rate variability of mice in the MPTP + CU-CPT22 group were also improved. Our results support the perspective that p-α-syn interacts with TLR2 induced SCs damage and is involved in PD AutD, which sheds fresh light on the mechanism of PD AutD and indicates a promising treatment for PD AutD targeting SCs p-α-syn/ TLR2 signaling pathway.
Large anomalous transverse transport properties in atomically thin 2D Fe3GaTe2
Authors: Marfoua Brahim , Hong Jisang 
Published: January 2024

Abstract
Anomalous transverse conductivities, such as anomalous Hall conductivity (AHC), anomalous Nernst conductivity (ANC), and anomalous thermal Hall conductivity (ATHC), play a crucial role in the emerging field of spintronics. Motivated by the recent fabrication of two-dimensional (2D) ferromagnetic thin film Fe3GaTe2, we investigate the thickness-dependent anomalous transverse conductivities of the 2D Fe3GaTe2 system (from one to four layers). The atomically ultrathin 2D Fe3GaTe2 system shows above-room-temperature ferromagnetism with a large perpendicular magnetic anisotropy energy. Furthermore, we obtain a large AHC of −485 S/cm in the four-layer thickness, and this is further enhanced to −550 S/cm with small electron doping. This AHC is seven times larger than the measured AHC in thicker 2D Fe3GaTe2 (178 nm). The ANC also reaches 0.55 A/K.m in the four-layer structure. Along with these, the four-layer system exhibits a large ATHC (−0.105 ~ −0.135 W/K.m). This ATHC is comparable to the large ATHC found in Weyl semimetal Co3Sn2S2. Based on our results, the atomically ultrathin 2D Fe3GaTe2 system shows outstanding anomalous transverse conductivities and can be utilized as a potential platform for future spintronics and spin caloritronic device applications.
Indirect H2O2 synthesis without H2
Authors: Fink Arthur G. , Delima Roxanna S. , Rousseau Alexandra R. , Hunt Camden , LeSage Natalie E. , Huang Aoxue , Stolar Monika , Berlinguette Curtis P. 
Published: January 2024

AbstractIndustrial hydrogen peroxide (H2O2) is synthesized using carbon-intensive H2 gas production and purification, anthraquinone hydrogenation, and anthrahydroquinone oxidation. Electrochemical hydrogenation (ECH) of anthraquinones offers a carbon-neutral alternative for generating H2O2 using renewable electricity and water instead of H2 gas. However, the H2O2 formation rates associated with ECH are too low for commercialization. We report here that a membrane reactor enabled us to electrochemically hydrogenate anthraquinone (0.25 molar) with a current efficiency of 70% at current densities of 100 milliamperes per square centimeter. We also demonstrate continuous H2O2 synthesis from the hydrogenated anthraquinones over the course of 48 h. This study presents a fast rate of electrochemically-driven anthraquinone hydrogenation (1.32 ± 0.14 millimoles per hour normalized per centimeter squared of geometric surface of electrode), and provides a pathway toward carbon-neutral H2O2 synthesis.