bluuebunny/crossref_metadata_2025_split huggingface dataset:
Radical gastrectomy is safe for treatment of gastric cancer patients on immunosuppressive drugs after organ transplantation
Authors: Lee Jin Ah , Kim So Jung , Seo Ho Seok , Lee Han Hong , Kim Sung Geun , Jun Kyong Hwa , Song Kyo Young , Jung Yoon Ju 
Published: January 2024

BackgroundDe novo malignancies are major causes of death after organ transplantation because the recipients subsequently receive immunosuppressant drugs. When gastric cancer develops, the clinical course of the tumor may be particularly aggressive. However, there are few reliable studies of gastric cancer treatment after organ transplantation. This study examined the clinicopathological characteristics of gastric cancer patients after organ transplantation and evaluated treatment outcomes after gastrectomy.MethodsClinical data were collected from 54 patients who were diagnosed with gastric cancer after organ transplantation. Of these, 30 who underwent surgery for gastric cancer while on immunosuppressant medications were compared with a control group of 625 gastric cancer patients. To compensate for clinical differences between the two groups, 1:1 propensity-score matching was performed.ResultsAmong the 30 gastric cancer patients on immunosuppressants, kidney transplantation was the most common procedure (19/30, 63.3%) followed by bone marrow (6) and liver transplantation (4); among all 54 patients, 45 were on one or two immunosuppressants. Up-migration to an advanced pathological stage was more frequent in the transplant group. In multivariate analysis, transplantation was a significant risk factor for up-migration from the T, M, and final stages after surgery. When the 30 patients on immunosuppressants who underwent gastric cancer surgery were compared with the matched controls, the total incidence (30.0 vs 40.0%, P = 0.417) and the number of severe postoperative complications (16.7 vs 13.4%, P = 0.417) did not differ significantly between groups after propensity score matching. In terms of overall survival, the transplant group showed significantly worse prognosis in stages I, II, and IV (P &lt; 0.001, P = 0.039 and 0.007, respectively).ConclusionRadical gastrectomy can be a safe oncological procedure for gastric cancer patients on immunosuppressants after transplantation. Considering their immunosuppressed condition and the possibility of underestimation of the stage of gastric cancer, early detection with endoscopic screening is needed to allow curative treatment.
Pathologic and immunohistochemical prognostic markers in residual triple-negative breast cancer after neoadjuvant chemotherapy
Authors: Ilie Silvia Mihaela , Briot Nathalie , Constatin Guillaume , Ilie Alis , Beltjens Francoise , Ladoire Sylvain , Desmoulins Isabelle , Hennequin Audrey , Bertaut Aurelie , Coutant Charles , Causeret Sylvain , Ghozali Niama , Coudert Bruno , Arnould Laurent 
Published: January 2024

BackgroundThe persistence of residual tumour after neoadjuvant chemotherapy (NAC) in localised triple-negative breast cancer (TNBC) is known to have a negative prognostic value. However, different degrees of expression of some immunohistochemical markers may correlate with different prognoses.MethodsThe expression of biomarkers with a known prognostic value, i.e., cytokeratin 5/6 (CK5/6), androgen receptor (AR), epidermal growth factor receptor (EGFR) proliferation-related nuclear antigen Ki-67, human epidermal growth factor receptor 2 (HER2), protein 53 (p53), forkhead box protein 3 (FOXP3), and cluster differentiation 8 (CD8), was analysed by immunohistochemistry in 111 samples after NAC in non-metastatic TNBC patients addressed to Georges-François Leclerc Cancer Centre Dijon, France. Clinical and pathological variables were retrospectively collected. Cox regression was used to identify immunohistochemical (IHC) and clinicopathological predictors of event-free survival (EFS) (relapse or death).ResultsMedian age was 50.4 years (range 25.6–88.3), 55.9% (n = 62) were non-menopausal, 70 (63.1%) had stage IIA–IIB disease. NAC was mostly sequential anthracycline-taxanes (72.1%), and surgical intervention was principally conservative (51.3%). We found 65.7% ypT1, 47.2% lymph node involvement (ypN+), and 29.4% lymphovascular invasion (LVI). Most residual tumours were EGFR &gt;110 (H-score) (60.5%, n = 66), AR ≥4% (53.2%, n = 58), p53-positive mutated (52.7%, n = 58), CD8 ≥26 (58.1%, n = 61), FOXP3 ≥7 (51.4%, n = 54), more than half in the stroma, and 52.3% (n = 58) HER2 score 0. After a median follow-up of 80.8 months, 48.6% had relapsed. Median EFS was 62.3 months (95% CI, 37.2–not reached (NR)). Factors independently associated with poor EFS were AR-low (p = 0.002), ypN+ (p &lt; 0.001), and LVI (p = 0.001). Factors associated with lower overall survival (OS) were EGFR-low (p = 0.041), Ki-67 high (p = 0.024), and ypN+ (p &lt; 0.001).ConclusionPost-NAC residual disease in TNBC showed biomarkers specific to a basal-like subtype and markers of lymphocyte infiltration mostly present in the stroma. Prognostic markers for EFS were AR, LVI, and ypN and warrant further validation in a prognostic model.
Effects of ketamine on rat social behavior as analyzed by DeepLabCut and SimBA deep learning algorithms
Authors: Popik Piotr , Cyrano Ewelina , Piotrowska Diana , Holuj Malgorzata , Golebiowska Joanna , Malikowska-Racia Natalia , Potasiewicz Agnieszka , Nikiforuk Agnieszka 
Published: January 2024

Traditional methods of rat social behavior assessment are extremely time-consuming and susceptible to the subjective biases. In contrast, novel digital techniques allow for rapid and objective measurements. This study sought to assess the feasibility of implementing a digital workflow to compare the effects of (R,S)-ketamine and a veterinary ketamine preparation Vetoquinol (both at 20 mg/kg) on the social behaviors of rat pairs. Historical and novel videos were used to train the DeepLabCut neural network. The numerical data generated by DeepLabCut from 14 video samples, representing various body parts in time and space were subjected to the Simple Behavioral Analysis (SimBA) toolkit, to build classifiers for 12 distinct social and non-social behaviors. To validate the workflow, previously annotated by the trained observer historical videos were analyzed with SimBA classifiers, and regression analysis of the total time of social interactions yielded R2 = 0.75, slope 1.04; p &lt; 0.001 (N = 101). Remarkable similarities between human and computer annotations allowed for using the digital workflow to analyze 24 novel videos of rats treated with vehicle and ketamine preparations. Digital workflow revealed similarities in the reduction of social behavior by both compounds, and no substantial differences between them. However, the digital workflow also demonstrated ketamine-induced increases in self-grooming, increased transitions from social contacts to self-grooming, and no effects on adjacent lying time. This study confirms and extends the utility of deep learning in analyzing rat social behavior and highlights its efficiency and objectivity. It provides a faster and objective alternative to human workflow.
Therapeutic drug monitoring of corticosteroids/β2-agonists in the hair of patients with asthma: an open-label feasibility study
Authors: Salvator Hélène , Lamy Elodie , Roquencourt Camille , Bardin Emmanuelle , Devillier Philippe , Grassin-Delyle Stanislas 
Published: January 2024

Background: Although adherence to inhaled medication is critically important for treatment efficiency, around half of patients taking these drugs are non-adherent or make critical errors when using their delivery device. Segmental hair analysis might be a valuable tool for therapeutic monitoring because hair concentrations reflect exposure from month to month. The objective of the present proof-of-concept study was to establish the feasibility of segmental hair analysis of inhaled budesonide and formoterol in asthma patients.Methods: We conducted a prospective, open-label, interventional study of adult patients being treated with budesonide/formoterol for controlled, moderate-to-severe asthma (CorticHair, NCT03691961). Asthma control, lung function, and medication adherence were recorded. Hair samples were taken 4 months after enrolment and cut into four 1 cm segments.Results: Samples were available from 21 patients (20 women; median age: 53; median budesonide dose: 600 μg/d). Budesonide and formoterol were detected in samples from 18 to 13 patients, respectively. The median hair concentrations were 6.25 pg/mg for budesonide and 0.9 pg/mg for formoterol. The intrapatient coefficient of variation between hair segments was 21% for budesonide and 40% for formoterol. Pearson’s coefficients for the correlations between the hair concentration and the self-reported drug dose and the prescribed drug dose were respectively 0.42 (p = 0.08) and 0.29 (p = 0.25) for budesonide and 0.24 (p = 0.44) and 0.17 (p = 0.57) for formoterol.Conclusion: Segmental hair analysis of inhaled medications was feasible, with low intrapatient variability. This innovative, non-invasive means of assessing monthly drug exposure might help physicians to personalize drug regimens for patients with difficult-to-treat asthma.
A dual design thinking – universal design approach to catalyze neurodiversity advocacy through collaboration among high-schoolers
Authors: Schuck Rachel K. , Fung Lawrence K. 
Published: January 2024

IntroductionNeurodiversity describes the fact that humans all have different brains with unique qualities that contribute to society. Though understanding of neurodiversity is gaining traction among the general public, there remains considerable stigma and prejudice toward neurodiverse people. One way to combat these issues is to teach individuals about neurodiversity and encourage them to develop advocacy skills. Development of such knowledge is especially important for adolescents, as they have the capacity to make small (e.g., interpersonal interactions) and large (e.g., school-wide) impacts.MethodsEighty-nine high schoolers participated in a two-week virtual summer camp in 2022; research consent/assent was obtained from 19 (11 neurodiverse/neurodivergent). Campers learned about neurodiversity, Universal Design for Learning (UDL), and Design Thinking (DT) through lectures from researchers and neurodivergent people, as well as group activities and discussions. Campers worked in small groups to design a neurodiversity advocacy project based on the principles of UDL and DT. Each group was facilitated by camp counselors–some of whom were neurodiverse–who were all committed to neurodiversity advocacy. Participants completed questionnaires about autism, ADHD, and dyslexia pre- and post-camp. Some also completed optional post-camp interviews.ResultsPre-camp stigma toward neurodiverse conditions was generally low. However, autism stigma was significantly higher than dyslexia stigma (Z = −2.24, p = 0.025). After camp, autism stigma decreased (Z = −2.98, p = 0.003;) and autism [t(13) = 3.17, p = 0.007] and ADHD [t(13) = 2.87, p = 0.013] knowledge improved. There were no significant changes in ADHD or dyslexia stigma or dyslexia knowledge. Participants reported enjoying collaborating with other campers and learning about UDL and DT. Thematic analysis of interviews generated four themes: Increased Understanding of Neurodiversity; Increasing Empathy and Becoming Less Judgmental; Creating a Neurodiverse Community; and More Awareness is Needed.DiscussionThis pilot investigation suggests that a virtual summer camp can be effective in improving attitudes toward and knowledge of neurodiversity. Qualitative analysis indicated participants became more accepting after the camp, both in terms of being less judgmental toward neurodiverse people and more self-accepting among neurodivergent campers. Future research should investigate the long-term effects of such a program, particularly with diverse samples of students.
Remote treatment of developmental dyslexia: how ADHD comorbidity, clinical history and treatment repetition may affect its efficacy
Authors: Lorusso Maria Luisa , Borasio Francesca , Mistò Paola , Salandi Antonio , Travellini Simona , Lotito Mariangela , Molteni Massimo 
Published: January 2024

IntroductionTachidino is a web-based platform for remote treatment of reading and spelling disorders. The purpose of the present study was to investigate the possible impact of different clinical conditions on the efficacy of treatment. The focus was on possible ADHD comorbidity-related effects on the outcomes of the Tachidino treatment, and the impact of previous treatments, such as speech and language therapy or the repetition of the same Tachidino program.Methods136 children with developmental dyslexia received four-weeks treatment via the Tachidino platform. Improvements in reading and writing scores were compared between different subgroups.ResultsNo gross differences emerged in treatment effectiveness between groups of children. Children receiving treatment improved significantly more than untreated children.DiscussionTreatment with Tachidino brought significant benefits for all children, irrespective of comorbidity, clinical history or treatment repetition. Comparison with an untreated control group (waiting list) made it possible to exclude that improvement was due to test–retest learning effects.
Association between sleep duration and burnout in healthcare professionals: a cross-sectional survey
Authors: Saintila Jacksaint , Soriano-Moreno Anderson N. , Ramos-Vera Cristian , Oblitas-Guerrero Susan M. , Calizaya-Milla Yaquelin E. 
Published: January 2024

BackgroundShort sleep duration in healthcare professionals is a recurring concern among researchers. On the other hand, the prevalence of burnout in this population group is experiencing exponential growth. Therefore, this study aimed to explore the association between sleep duration and burnout in healthcare professionals.MethodsThis is a cross-sectional study. Data were collected by applying a non-probabilistic convenience sampling, considering a sample of 300 healthcare professionals from the public sector in Peru. The association between variables was explored using multivariate logistic regression. Values of p &lt; 0.05 were considered statistically significant.ResultsThe results of the analysis in the crude models revealed that both men and women who slept &lt; 7 h during workdays and days off were 8.33 (95% CI = 2.68–13.99, p = 0.004) and 17.18 (95% CI = 10.50–23.87, p &lt; 0.001) times more likely to have burnout compared to those who reported ≥7 h, respectively. After adjusting for confounding variables, the association remained statistically significant.ConclusionThe findings of this study underscore the critical importance of sleep duration in the incidence of burnout among healthcare professionals. In the context of the global challenges to the mental and physical health of these professionals, our results highlight the urgent need to implement strategies at the organizational and individual level. This includes promoting a better work-life balance, and effective stress management and improved sleep quality.
R-Matrix Calculation of Electron Collision with the BeO+ Molecular Ion
Authors: Mukherjee Nilanjan , Bhattacharyya Abhijit , Chakrabarti Kalyan 
Published: January 2024

We report here an R-matrix study of electron collision with the BeO+ molecular ion in its X 2Π ground state and at a single bond length, namely its equilibrium Re=2.7023 a0. Firstly, a good quality configuration interaction calculation is performed for the BeO+ ground and excited states. We then perform scattering calculations using the R-matrix method to yield the cross-section for electronic excitation to several of its excited states. The electron impact dissociation of BeO+ through the two lowest dissociation channels, namely the Be+(2Sg) + O(3Pg) and Be+(2Sg) + O(1Dg) dissociation channels, is estimated using the electronic excitation cross-sections. Rotational excitation cross-sections are provided for the j(=0)→j′(=1,2,3) rotational transitions. Our calculations also yield e + BeO+ neutral Feshbach resonances and their widths which we present systematically categorized by their symmetry and quantum defects, and BeO-bound Rydberg states at the BeO+ equilibrium. The full potential energy curves for the resonant states, their widths and the bound Rydberg states, whose details we propose to give in a subsequent work, can be the starting point of other collision calculations.
Comment on oriente les élèves. Des jugements professoraux aux négociations familiales
Authors: Chauvel Séverine 
Published: January 2024

À la fin de la troisième, le taux d'élèves de Seine-Saint-Denis orientés en seconde générale ou technologique à la rentrée 2006 est, selon le Service académique d'information et d'orientation de Créteil, de 58,3 %, proche de la moyenne nationale (60,1 %), avec des variations entre les établissements : 43,5 % des élèves des DEUX collèges de notre enquête s'orientent dans cette voie. Comment comprendre ces différences ? Quels sont les processus qui conduisent les familles à exprimer des choix d'orientation et comment prendre en compte les effets de l'école sur ce choix, en particulier ce que produisent les logiques de sélection des enseignants ?
REQUIREMENTS FOR METRICS AND CONTENT OF THE METHODICAL APPARATUS FOR PLANNING THE DEVELOPMENT OF TELECOMMUNICATIONS INFRASTRUCTURE AND ELIMINATING DIGITAL INEQUALITY
Authors: Захаров А.А. , Лопато C.И. , Короткова А.Г. , Кизима С.В. 
Published: January 2024

Статья посвящена проблематике цифрового неравенства, определяемого различиями состава, уровней стоимости и качества услуг телекоммуникационной инфраструктуры, предоставляемых потребителям в регионах, территориальных районах и точках геопространства. Систематизированные требования к моделям и метрикам потребителей и поставщиков услуг телекоммуникационной инфраструктуры направлены на получение количественных оценок величин баланса спроса и предложения услуг и индикаторов цифрового неравенства. Предлагаемые модели и метрики способствуют определению уровней развития телекоммуникационной инфраструктуры в регионах и территориальных районах. Ключевые слова: цифровое неравенство, телекоммуникационная инфраструктура, геопространство, модели потребителей и поставщиков услуг, индикаторы, метрики, уровни развития телекоммуникационной инфраструктуры
The article is devoted to the problems of digital inequality, determined by differences in the composition, cost levels, and quality of telecommunications infrastructure services provided to consumers in regions, territorial areas, and points of geospatial space. The systematized requirements for models and metrics of consumers and providers of telecommunications infrastructure services are aimed at obtaining quantitative estimates of the balance of supply and demand for services and indicators of digital inequality. The proposed models and metrics contribute to determining the levels of development of telecommunications infrastructure in regions and territorial areas.
ABOUT THE CONCEPT OF AN OPEN APPLICATION PROGRAMMING INTERFACE IMPLEMENTATION IN THE TELECOMMUNICATIONS MARKET
Authors: Кутепов М.Ю. , Бухарев И.А. , Плахов В.В. 
Published: January 2024

Приведен краткий анализ существующих подходов и тенденций в реализации унифицированных методологий внедрения прикладных программных интерфейсов (API), получивших название открытых API, а также рассмотрены варианты реализации обозначенного подхода на телекоммуникационном рынке Российской Федерации.
The article provides a brief analysis of existing approaches and trends in the implementation of unified methodologies for the implementation of application program interfaces called Open APIs, and considers options for implementing in the telecommunications market of the Russian Federation.
OPEN RAN FOR 6G MOBILE NETWORKS
Authors: Константинова А.А. , Пальцин Д.А. , Захаров А.А. , Фень А.C. , Цым А.Ю. , Шалагинов А.В. 
Published: January 2024

Развитию технологии Open RAN уделяется первоочередное внимание в мировой телекоммуникационной отрасли как основе сетей мобильной связи 6G, призванных стать основой экономики данных. Open RAN устраняет основные недостатки традиционной RAN, такие как привязка к поставщику, негибкость управления и автоматизации, высокое энергопотребление и необходимость больших инвестиций. Эти недостатки преодолеваются с помощью децентрализации, виртуализации и открытых стандартных интерфейсов между компонентами, что открывает рынок RAN для инноваций, новых участников и внедрения новых сервисов, а также значительно снижает совокупную стоимость владения сетью для операторов.
The development of Open RAN has a high priority in the global telecom industry as the basis of 6G mobile communication networks, designed to become a pillar of the data economy. O-RAN addresses the main drawbacks of traditional RAN, such as vendor lock-in, management and automation inflexibility, high power consumption, and the need for large investments. These shortcomings can be overcome through decentralization, virtualization, and open standard interfaces between components, which opens the RAN market to innovations and new participants, increases the adoption of new services, and significantly reduces the total cost of ownership for operators.
Eksplorasi Bentuk Arsitektur dan Tradisi Rumah Gadang Rajo Babandiang di Minangkabau
Authors: Tedy Wiraseptya  , Stefvany  
Published: January 2024

Rumah gadang adalah rumah tradisional suku Minangkabau yang dapat ditemukan di daerah Sumatera Barat, Indonesia. Cirikhas rumah gadang memiliki atap berbentuk seperti tanduk kerbau yang disebut “gonjong”. Jenis-jenis rumah gadang memiliki banyak bentuk, salah satu bentuk yang diteliti ialah rumah gadang Rajo Babandiang. Penelitian ini bertujuan untuk mengeksplorasi arsitektur dan tradisi rumah gadang Rajo Babandiang atau dikenal dengan rumah gadang gonjong lima. Menggunakan analisa kualitatif, penelitian ini data yang dikumpulkan melalui studi pustaka, wawancara serta observasi lapangan. Kemudian untuk mengungkap nilai budaya dari rumah gadang Rajo Babandiang menggunakan metode etnografi. Hasil penelitian ini menunjukkan bahwa rumah gadang Rajo Babandiang merupakan contoh arsitektur tradisional yang unik dan kaya nilai budaya. Struktur rumah ini didesain untuk menyesuaikan dengan lingkungan alam sekitarnya serta penyesuaian kebutuhan di dalam rumah dengan kehidupan keluarga. Desain bentuk dalam eksplorasi penelitian ini dibuat sketsa rancangan bentuk dan illustrasi 3D rumah gadang Rajo Babandiang. Penelitian ini memiliki implikasi penting dalam melestarikan dan mengembangkan arsitektur tradisional di Sumatera Barat, Indonesia. Sehingga hasil penelitian ini dapat dijadikan referensi bagi para desainer dalam merancang bangunan yang berkelanjutan dan memperhatikan aspek kearifan lokal.