bluuebunny/crossref_metadata_2025_split huggingface dataset:
Cryptic diversity begets challenges and opportunities in biodiversity research
Authors: CHENG Rui , LUO Arong , ORR Michael , GE Deyan , HOU Zhong'e , QU Yanhua , GUO Baocheng , ZHANG Feng , SHA Zhongli , ZHAO Zhe , WANG Mingqiang , SHI Xiaoyu , HAN Hongxiang , ZHOU Qingsong , LI Yuanning , LIU Xingyue , SHAO Chen , ZHANG Aibing , ZHOU Xin , ZHU Chaodong 
Published: January 2024

AbstractHow many species of life are there on Earth? This is a question that we want to know but cannot yet answer. Some scholars speculate that the number of species may reach 2.2 billion when considering cryptic diversity and that each morphology‐based insect species may contain an average of 3.1 cryptic species. With nearly two million described species, such high estimates of cryptic diversity would suggest that cryptic species are widespread. The development of molecular species delimitation has led to the discovery of a large number of cryptic species, and cryptic biodiversity has gradually entered our field of vision and attracted more attention. This paper introduces the concept of cryptic species, how they evolve, and methods by which they may be discovered and confirmed, and provides theoretical and methodological guidance for the study of hidden species. A workflow of how to confirm cryptic species is provided. In addition, the importance and reliability of multi‐evidence‐based integrated taxonomy are reaffirmed as a way to better standardize decision‐making processes. Special focus on cryptic diversity and increased funding for taxonomy is needed to ensure that cryptic species in hyperdiverse groups are discoverable and described. An increased focus on cryptic species in the future will naturally arise as more difficult groups are studied, and thereby, we may finally better understand the rules governing the evolution and maintenance of cryptic biodiversity.
Relationships between protein and other chemical composition and texture of tofu made from soybeans grown in different locations
Authors: Chen Ruiqi , Chang Sam K. C. , Gillen Anne M. , Chen Pengyin , Zhang Bo 
Published: January 2024

AbstractUnderstanding quantitative relationships between protein and other chemical components in diverse soybean genotypes (lines) grown in different locations and the firmness of tofu can provide scientific insight for selecting soybean suitable for tofu making. Locations showed significant effects on seed components, including total protein, major storage proteins, subunits and polypeptides of the major storage proteins, and calcium, but not magnesium or phytic acid. Results showed that 11S content, but not 11S/7S ratio, was only correlated with filled tofu firmness when analyzed over all locations. A strong and positive correlation between firmness and A3 polypeptide of the 11S protein content was found for both pressed tofu (r = 0.80, p < 0.001) and filled tofu (r = 0.76, p < 0.001) over three locations (overall pooled data) and within most individual locations. The correlation of filled tofu firmness and A3 polypeptide was significant for each of the three individual locations. However, the correlation of pressed tofu firmness and A3 polypeptide content was significant at two of three locations. Mean calcium content was positively correlated with mean pressed and filled tofu firmness over all locations, but calcium was not correlated with pressed tofu firmness at any individual location, and only one location showed a significant correlation of calcium and filled tofu firmness. In addition, pressed tofu firmness was found to be negatively correlated with tofu yield. The findings that A3 polypeptide's strong relationship with tofu firmness within certain locations may be used by the food industry to select proper soybean for manufacturing tofu and to facilitate tofu soybean breeding for tofu making.
Relationship between CD274 gene polymorphism and systemic lupus erythematosus risk in a Chinese Han population
Authors: Yang Lu‐Qi , Qin Zhen , Fu Lu , Xu Wang‐Dong 
Published: January 2024

AbstractObjectiveRelationship between surface antigen differentiation cluster 274 (CD274) gene polymorphism and systemic lupus erythematosus (SLE) risk is limited. This study aims to discuss whether in a Chinese Han population, CD274 gene polymorphisms may relate to SLE susceptibility.MethodsThree hundred and ten SLE patients and 390 healthy controls were included in this case–control study. Using the Kompetitive Allele‐Specific PCR (KASP) approach, five single nucleotide polymorphisms (SNPs), including rs2890658, rs4143815, rs822339, rs2282055, and rs2297137, were genotyped for CD274 gene polymorphisms. Correlation between the polymorphisms and clinical, laboratory features in SLE patients were discussed.ResultsFrequency of C allele was substantially lower in SLE patients than in healthy controls (p = .015), and CC genotype was significantly negatively related to developing SLE at locus rs4143815 (p = .013). At locus rs822339, frequency of GA genotype was higher than that of the healthy controls (p = .006). At locus rs2282055, frequency of GG genotype was lower than that of healthy controls (p = .024). According to subgroup analysis, the CD274 gene polymorphisms rs2890658, rs4143815, rs822339, rs2282055, and rs2297137 were partly linked to some clinical symptoms of SLE patients, such as Complement 4 (C4), C‐reactive protein (CRP), and erythrocyte sedimentation rate (ESR).ConclusionCD274 gene polymorphisms may be susceptible to SLE in the Chinese Han people.
Anti‐MDA5 antibody‐associated clinically amyopathic dermatomyositis diagnosed after the onset of pulmonary hypertension
Authors: Yang Y. , Huang X. , Lin J. 
Published: January 2024

AbstractIdiopathic inflammatory myopathies (IIM) are a group of highly heterogeneous systemic autoimmune diseases, of which clinically amyopathic dermatomyositis (CADM) is a distinct sub‐type. Pulmonary hypertension (PH) is a life‐threatening medical condition that can occur as a complication of connective tissue diseases. Herein, our report first suggests that PH can develop in CADM. A 48‐year‐old woman came to our hospital due to a 3 months history of facial edema and shortness of breath. Relevant examinations revealed Gottron's sign, normal creatinine kinase levels, elevated levels of mean pulmonary artery pressure, double‐positive anti‐MDA5 and anti‐Ro52 antibodies, and typical pathological changes associated with myositis. The diagnosis of CADM combined with PH was considered. The patient responded well to the immunosuppression therapy and PH‐related drug therapy. We provide further insights that patients with IIM need to undergo regular assessment of PH.
Circular subsidiarity: Humanizing work through relational goods
Authors: González Ana Marta , Scalzo Germán 
Published: January 2024

AbstractThe Fourth Industrial Revolution based on digitalization, the development of AI, robotics, big data, and increasing automation is dredging up older debates on the end of human work. This article contributes to this debate arguing that these changing circumstances represent an opportunity to advance a renewed consideration of human work. By emphasizing its most distinctively human dimensions, including gratuitousness, relationality, and meaningfulness, we propose the articulation of a social model that recognizes relational goods as a specific contribution of human work in an attempt to overcome the state and the market's monopoly of public life built around the dichotomy between the private and the public. Such a social model is based on the concept of circular subsidiarity, which represents a departure from traditional notions of subsidiarity by promoting a dynamic and reciprocal interplay between three essential societal spheres: the state, the market, and organized civil society, all of which have their role to fulfill by providing security, efficiency, and relational goods. Ultimately, this article suggests that circular subsidiarity can lead to a more inclusive and equitable social model by acknowledging how relational goods not only humanize civil society but also sustain the functioning of both the market and the state.
Matrine inhibits cell proliferation, invasion, and stem cell formation in hepatocellular carcinoma by regulating the ELAVL1/RBM3‐mediated Wnt/β‐catenin signaling pathway
Authors: Song Chunhua , Li Hongwei , Huang Zhengchun , Chang Xinfeng , Pan Wen , Zhang Zhihua 
Published: January 2024

AbstractMatrine has been reported to exert anti‐tumor effects in various cancers, including hepatocellular carcinoma (HCC). Nevertheless, the anti‐tumor molecular mechanism of Martine in HCC is still not fully revealed. Cell proliferative ability, apoptosis, invasion, and sphere formation ability were detected using 3‐(4, 5‐dimethyl‐2‐thiazolyl)‐2, 5‐diphenyl‐2‐H‐tetrazolium bromide (MTT), 5‐ethynyl‐2′‐deoxyuridine (EdU), flow cytometry, transwell, and sphere formation assays. CyclinD1, MMP2, RNA‐binding motif protein 3 (RBM3), embryonic lethal abnormal visual‐like protein 1 (ELAVL1), Wnt3A, and β‐catenin protein levels were assessed using western blot. RBM3 and ELAVL1 expression was measured using real‐time quantitative polymerase chain reaction (RT‐qPCR). After being predicted using Starbase, the possible interaction between ELAVL1 and RBM3 was identified using Co‐Immunoprecipitation (IP) assays. A xenograft model was used to examine how Matrine affects HCC cell growth in vivo. Matrine hindered HCC cell proliferation, invasion, and sphere formation ability, and boosted apoptosis in vitro. ELAVL1 and RBM3 content was decreased in Matrine‐treated HCC cells in a concentration‐dependent manner and was increased in HCC tissues and cell lines. Moreover, ELAVL1 might bind with RBM3 to positively regulate the stability of RBM3 mRNA. Matrine modulated the Wnt/β‐catenin signaling pathway by ELAVL1/RBM3 axis. Matrine blocked tumor growth in xenograft modes in vivo. Matrine suppressed HCC cell progression partly by regulating the ELAVL1/RBM3, providing the possible therapeutic strategy for HCC treatment.
Global retinoblastoma studies: A review
Authors: Vempuluru Vijitha S. , Maniar Arpita , Kaliki Swathi 
Published: January 2024

AbstractIn the current era of global health awareness for retinoblastoma (RB), the challenge that lies ahead of us is providing optimal care for children affected with RB in underdeveloped nations. The understanding of similarities and disparities between various nations across the world aids in achieving comparable outcomes. With dissolving geographic barriers and evolving collaboration, global collaborative studies on RB are becoming increasingly common. They provide real‐world, robust evidence on several aspects of RB. This review discusses insights gained from global RB studies regarding the demographics, certain aspects of etiopathogenesis and epidemiology, international travel burden, disparities in clinical presentations based on national income levels, management protocols, pathology, treatment outcomes, and the effect of COVID‐19 on RB care across the world. These insights are likely to impact individual practice as well as inform policy reforms.
Association between donor kidney cysts and donor and recipient outcomes after living donor kidney transplantation
Authors: Emmons Brendan R. , Adler Joel T. , Sandoval Pedro Rodrigo , King Kristen L. , Yu Miko , Cron David C. , Mohan Sumit , Ratner Lloyd E. , Husain Syed Ali 
Published: January 2024

AbstractIntroductionIncidental kidneys cysts are typically considered benign, but the presence of cysts is more frequent in individuals with other early markers of kidney disease. We studied the association of donor kidney cysts with donor and recipient outcomes after living donor kidney transplantation.MethodsWe retrospective identified 860 living donor transplants at our center (1/1/2011–7/31/2022) without missing data. Donor cysts were identified by review of pre‐donation CT scan reports. We used linear regression to study the association between donor cysts and 6‐month single‐kidney estimated glomerular filtration rate (eGFR) increase, and time‐to‐event analyses to study the association between donor cysts and recipient death‐censored graft failure.ResultsAmong donors, 77% donors had no kidney cysts, 13% had ≥1 cyst on the kidney not donated, and 11% only had cysts on the donated kidney. In adjusted linear regression, cysts on the donated kidney and kidney not donated were not significantly associated with 6‐month single‐kidney eGFR increase. Among transplants, 17% used a transplanted kidney with a cyst and 6% were from donors with cysts only on the kidney not transplanted. There was no association between donor cyst group and post‐transplant death‐censored graft survival. Results were similar in sensitivity analyses comparing transplants using kidneys with no cysts versus 1–2 cysts versus ≥3 cysts.ConclusionsKidney cysts in living kidney donors were not associated with donor kidney recovery or recipient allograft longevity, suggesting incidental kidney cysts need not be taken into account when determining living donor candidate suitability or the laterality of planned donor nephrectomy.
Efficacy of intravenous clonazepam for paediatric convulsive status epilepticus
Authors: Colmard Maxime , Rivier François , de Barry Gaëlle , Roubertie Agathe , Urtiaga‐Valle Sarai , Mercedes‐Alvarez Blanca , Combes Clementine , Cambonie Gilles , Milesi Christophe , Meyer Pierre 
Published: January 2024

AbstractAimTo compare the efficacy of intravenous clonazepam (CLZ) for the initial management of convulsive status epilepticus (CSE) in children as a function of the first‐line in‐hospital dose used.MethodThis monocentric retrospective study included children who received a first dose of CLZ for CSE at Montpellier University Hospital, France, between January 2016 and June 2019. Data from medical records (clinical, treatment, course) were collected and compared as a function of the first CLZ dose used.ResultsAmong the 310 children treated for CSE, 105 received at least one CLZ dose (median age 3 years; quartile 1–quartile 3 [Q1–Q3] = 1 years 2 months–6 years 6 months). Among these 105 patients, 24 (22%) received a dose less than 0.03 mg/kg (low dose) and 69 (65%) received a dose of at least 0.03 mg/kg (high dose). Seizure cessation rate was not different between the low‐ and high‐dose groups (62.5% vs 76%; odds ratio 0.53, 95% confidence interval [CI] 0.19–1.44, p = 0.29). The administration of a second dose of CLZ was more frequent in the low‐ than the high‐dose group (37.5% vs 16%; odds ratio 3.2, 95% CI 1.1–9.1, p = 0.04).InterpretationOur study did not find any difference in seizure termination rate as a function of CLZ dose in children with CSE. However, a second CLZ dose was more frequently needed in the group receiving low (less than 0.03 mg/kg) CLZ.
Electroencephalographic microstates as a potential neurophysiological marker differentiating bilateral from unilateral temporal lobe epilepsy
Authors: Baldini Sara , Duma Gian Marco , Danieli Alberto , Antoniazzi Lisa , Vettorel Airis , Baggio Martina , Da Rold Martina , Bonanni Paolo 
Published: January 2024

AbstractObjectiveElectroencephalographic (EEG) microstate abnormalities have been documented in different neurological disorders. We aimed to assess whether EEG microstates are altered also in patients with temporal epilepsy (TLE) and whether they show different activations in patients with unilateral TLE (UTLE) and bilateral TLE (BTLE).MethodsNineteen patients with UTLE, 12 with BTLE, and 15 healthy controls were enrolled. Resting state high‐density electroencephalography (128 channels) was recorded for 15 min with closed eyes. We obtained a set of stable scalp maps representing the EEG activity, named microstates, from which we acquired the following variables: global explained variance (GEV), mean duration (MD), time coverage (TC), and frequency of occurrence (FO). Two‐way repeated measures analysis of variance was used to compare groups, and Spearman correlation was performed to study the maps in association with the clinical and neuropsychological data.ResultsPatients with BTLE and UTLE showed differences in most of the parameters (GEV, MD, TC, FO) of the four microstate maps (A–D) compared to controls. Patients with BTLE showed a significant increase in all parameters for the microstates in Map‐A and a decrease in Map‐D compared to UTLE and controls. We observed a correlation between Map‐A, disease duration, and spatial short‐term memory, whereas microstate Map‐D was correlated with the global intelligence score and short‐term memory performance.SignificanceA global alteration of the neural dynamics was observed in patients with TLE compared to controls. A different pattern of EEG microstate abnormalities was identified in BTLE compared to UTLE, which might represent a distinctive biomarker.
Autonomy and overparenting: Are parents of emerging adults being responsive?
Authors: Jiao Jian , Pitts Margaret Jane , Segrin Chris 
Published: January 2024

AbstractRecognizing the various negative consequences of overparenting for the child such as poor mental health and relationship quality and delayed transition to full adulthood, this study examined to what extent parents of emerging adults were being responsive and tailoring their parenting practices to meet their child's characteristics, such as need for autonomy and trait autonomy. Survey data from 256 parent‐emerging adult child dyads were used for analyses. The results showed that parent‐reported overparenting was not associated with child‐reported autonomy features. Nevertheless, parents engaged in lower levels of tangible assistance and higher levels of advice/affect management if they perceived their child as high in autonomy need or trait autonomy. Collectively, these findings suggest that parents might practice overparenting out of their own desires and needs rather than taking into account their child's developmental needs and traits. Practical recommendations for family therapists are offered.
Migrate to (not) be ‘gurus’: Unpacking workplace masculinity in China's tech sector
Authors: Li Xiaotian , Chan Jenny 
Published: January 2024

AbstractThrough an intersectional analysis of gender, class, and migration, this article reveals how a hegemonic culture of workplace masculinity, embodied by a group of ‘gurus,’ is constructed in China's tech companies. The guru masculinity is characterized by proactivity and aggressiveness at work, ‘putting work first’ and overwork, and the ability to navigate boundaryless careers and settle down in first‐tier cities. It translates hegemonic masculine norms of material success, enjoying urban life, and men's breadwinner position in contemporary China on the one hand, and responds to a labor regime of precarious employment relations and prevalent overwork norm on the other hand. The article contributes to the literature on hegemonic masculinity in work organizations by showcasing how a hegemonic masculinity in China's tech workplace is constructed at the conjuncture of hegemonic gender norms at a societal level and the distinct labor regime in the tech sector. It also reveals that many male workers fail to conform to this cultural ideal, experiencing masculine frustration rooted in the nature of the ‘workplace masculinity contest,’ uneven urban development, and the demanding labor regime. It thus opens further discussions on how men resist hegemonic gender norms and construct alternative masculinities.
Risk of map‐like redness development after eradication therapy for Helicobacter pylori infection
Authors: Matsumoto Sho , Sugimoto Mitsushige , Fukuzawa Masakatsu , Uesugi Nana , Iwata Eri , Kagawa Yasuyuki , Madarame Akira , Koyama Yohei , Morise Takashi , Uchida Kumiko , Yamaguchi Hayato , Kono Shin , Naito Sakiko , Kawai Takashi , Itoi Takao 
Published: January 2024

AbstractBackgroundMap‐like redness is a newly identified endoscopic risk factor for gastric cancer in patients who received Helicobacter pylori eradication therapy. However, the incidence rate of map‐like redness in patients who received eradication, and the risk factors for the development of map‐like redness remain unclear. We hence aimed to investigate the incidence rate of map‐like redness at 1‐year post H. pylori eradication, and evaluated its associations with map‐like redness and gastric cancer in relation with gastric condition.Materials and MethodsEndoscopic severity of gastritis and map‐like redness were retrospectively evaluated according to the Kyoto Classification of Gastritis in patients who had undergone endoscopy before and after H. pylori eradication therapy.ResultsThe incidence rate of map‐like redness for all 328 patients at a mean of 1.2 ± 0.6 years after eradication was 25.3% (95% confidence interval [CI]: 20.7%–30.4%). Patients who developed map‐like redness were older, had more severe atrophy and intestinal metaplasia, a higher total score of the Kyoto Classification of Gastritis both before and after eradication, and a higher rate of gastric cancer history than patients who did not have map‐like redness. On multivariate analysis, risk of map‐like redness was increased in patients with intestinal metaplasia (odds ratio [OR]: 2.794, 95% CI: 1.155–6.757) and taking acid inhibitors (OR: 1.948, 95% CI: 1.070–3.547). Characteristics of H. pylori‐positive patients with gastric cancer history were patients who were older (OR: 1.033, 95% CI: 1.001–1.066), taking acid inhibitors (OR: 4.456, 95% CI: 2.340–8.484), and with occurrence of map‐like redness after eradication therapy (OR: 2.432, 95% CI: 1.264–4.679).ConclusionsMap‐like redness is observed in one fourth of patients at 1‐year post eradication. Patients who developed map‐like redness were found to have severe intestinal metaplasia and taking acid inhibitors, and hence such patients require increased attention at surveillance endoscopy.
Evaluation of in vitro prebiotic effects of galactomannan oligosaccharides derived from guar gum
Authors: Zhang Jing , Gao Zihan , Wang Guangzhen , Yang Xiaojun , Tong Yanjun , Zhao Wei 
Published: January 2024

SummaryGalactomannan oligosaccharides (GMOS) have been designated as the second generation of prebiotics. This study aimed to systematically investigate the prebiotic effects of GMOS. GMOS were obtained by the hydrolysis of guar gum (5 g L−1) using β‐mannanase (160 U g−1) for 4 h, with the molecular weight significantly decreased to 665 Da. The prebiotic activity of GMOS was verified, which displayed a great proliferation effect on Lactobacillus and Bifidobacterium. After in vitro faecal fermentation, GMOS greatly improved the production of total short‐chain fatty acids (43.62 mM), especially butyric acid (7.44 mM). Meanwhile, the relative abundance of several beneficial bacteria, including Megasphaera, Lactobacillus, and Bifidobacterium, was greatly improved to 41.15%. Besides, the total relative abundance of several typical harmful bacteria decreased to 37.80%, indicating that GMOS can regulate the composition of intestinal flora. These results provide an important scientific basis for the further use of GMOS as a prebiotic.