bluuebunny/crossref_metadata_2025_split huggingface dataset:
Cost of integrated immunization campaigns in Nigeria and Sierra Leone: bottom-up costing studies
Authors: Boonstoppel Laura , Moi Flavia , Banks Christina , Sibeudu Florence , Obodoechi Divine , Borces Kyle , Onwujekwe Obinna , Brenzel Logan 
Published: February 2024

Abstract

Background
To improve the efficient use of scarce resources, low- and middle-income countries and development partners are increasingly encouraged to deliver multiple vaccines and other interventions in a single integrated campaign. However, little is known regarding the cost of delivering vaccines through integrated campaigns, and the extent to which efficiencies are achieved. To fill this evidence gap, we estimated the cost of integrated immunization campaigns in Nigeria and Sierra Leone, and the potential savings from integration.
Methods
We conducted a retrospective ingredients-based costing study from a payer perspective of a campaign held in 2019 in Sierra Leone with measles-rubella vaccine and oral polio vaccine, during which nutrition supplements were also offered in part of the country, and yellow fever campaigns held in three states in Nigeria in 2019 and 2020, where in one state (Anambra) meningococcal A vaccines were co-delivered. We collected data from 108 health facilities, all relevant administrative levels, and implementing partners. We estimated the full financial and economic cost of each campaign, the average unit cost of delivery, as well as the cost by activity and resource type. We also estimated the cost savings from integration in Anambra state by modelling out the cost of the alternative of two standalone campaigns.
Results
The average financial delivery cost was $0.34 per dose in Sierra Leone, and the economic cost was $0.73 per dose. In Nigeria, the financial cost per dose was $0.29–$0.35 across the three states, and the economic cost per dose was $0.62–$0.85. Facilities and wards delivering more doses achieved a lower financial and economic unit cost of delivery, demonstrating evidence of economies of scale. We estimated that Anambra may have saved at least $1,204,133 in financial resources by integrating yellow fever and meningitis A vaccine delivery, amounting to $0.17 per dose delivered. When including opportunity costs, the economic cost saving was estimated at $0.34 per dose delivered.
Conclusions
The study offers evidence on what it costs to deliver integrated campaigns, and shows that integrated delivery is likely to result in significant cost savings. Where high delivery volumes can be achieved, integrated campaigns can benefit from economies of scale. The findings can be used to inform planning and budgeting for immunization campaigns in low- and middle-income countries.
The durability of different anchoring points and anchoring types in the left ventricle in an ex-vivo porcine model
Authors: Bjursten Henrik , Wierup Per , Koul Sasha , Settergren Magnus , Götberg Matthias , dencker magnus 
Published: February 2024

Abstract

Objective: Various percutaneous approaches are under development to perform transcatheter treatment of mitral valve disease, where many try to anchor in the left ventricle. This pilot study investigates the durability of different anchoring points and types in the left ventricle. Anchoring was tested in three different locations: the head of the papillary muscle, the lateral wall of the ventricle, and the apex of the ventricle. In addition, two different anchoring types were tested: PTFE sutures that mimicked mitral valve repair and a de novo developed 5 mm helix.
Results: The lowest numerical strain/compliance during the first cycle was seen for the head of papillary muscle anchoring (both surgical and helix). Migration of strain limits over 300 cycles was seen for all locations. Numerically, the lowest migration was for the helix in the papillary muscle. PTFE in the head of the papillary muscle is standard practice in mitral valve repair and was used as a reference in the present study. The anchoring that gave the most consistent results was a helix in the papillary muscle, while other anchoring points showed larger compliance and/or migration.
Clinical impact and cost-consequence analysis of ePlex® Blood Culture Identification Panels for the rapid diagnosis of bloodstream infections: a single-center randomized controlled trial
Authors: Caspar Yvan , Deves Arthur , Richarme Claire , Marechal Marion Le , Pondérand Léa , Mounayar Anne Laure , Lejeune Sophie , Arata-Bardet Julie , Gallouche Meghann , Recule Christine , Maubon Danièle , Garnaud Cécile , Cornet Muriel , Veloso Mélanie , Chabani Bilel , Maurin Max , David-Tchouda Sandra , Pavese Patricia 
Published: February 2024

Abstract
Purpose. To assess clinical impact and perform cost-consequence analysis of the broadest multiplex PCR panels available for the rapid diagnosis of bloodstream infections (BSI).
Methods. Single-center, randomized controlled trial conducted from June 2019 to February 2021 at a French University hospital with an institutional antimicrobial stewardship program. Primary endpoint was the percentage of patients with optimized antimicrobial treatment 12h after transmission of positivity and Gram stain results from the first positive BC.
Results. This percentage was significantly higher in the multiplex PCR (mPCR) group (90/105 = 85.7% %, IC95% [77.5 ; 91.8] vs. 68/107 = 63.6%, IC95% [53.7 ; 72.6]; p<10-3) at interim analysis, resulting in the early termination of the study after the inclusion of 309 patients. For patients not optimized at baseline, the median time to obtain an optimized therapy was much shorter in the mPCR group than in the control group (6.9h, IQR [2.9; 17.8] vs 26.4h, IQR [3.4; 47.5]; p=0.001). Early optimization of antibiotic therapy resulted in a non-statistically significant decrease in mortality from 12.4% to 8.8% (p=0.306), with a tendency for a lower median length of stay (18 vs. 20 days; p=0.064) and a non-significant reduction in the average cost per patient of €3,065 (p=0.15). mPCR identified all the bacteria present in 88% of the samples.
Conclusion. Despite its higher laboratory cost, the use of multiplex PCR for BSI diagnosis leads to early-optimised therapy, seems cost-effective and could reduce mortality and length of stay. Their impact could probably be improved if implemented 24/7.
A mathematical-computational model explains phenotypic plasticity changes by mutations underlying hepatic cancer stem cells emergence
Authors: Álvarez-Buylla Elena R. , Hernández-Magaña Alexis , Bensussen Antonio , Martinez-Garcia Juan Carlos 
Published: February 2024

Abstract

In several carcinomas, including hepatocellular carcinoma, it has been demonstrated that cancer stem cells (CSCs) have enhanced invasiveness and therapy resistance compared to differentiated cancer cells. Mathematical-computational tools could be valuable for integrating experimental results and understanding the phenotypic plasticity mechanisms for CSCs emergence. Based on the literature review, we constructed a Boolean model that recovers eight stable states (attractors) corresponding to the gene expression profile of hepatocytes and mesenchymal cells in senescent, quiescent, proliferative, and stem-like states. The epigenetic landscape associated with the regulatory network was analyzed. We observed that the loss of p53, p16, RB, or the constitutive activation of β-catenin and YAP1 increases the robustness of the proliferative stem-like phenotypes. Additionally, we found that p53 inactivation facilitates the transition of proliferative hepatocytes into stem-like mesenchymal phenotype. Thus, phenotypic plasticity may be altered, and stem-like phenotypes related to CSCs may be easier to attain following the mutation acquisition.
A numerical study of Lamb wave localisation in thin plates using a passive co-linear phased array
Authors: Pollock Luke , Wild Graham 
Published: February 2024

Abstract
Lamb waves have become increasingly popular in the field of aerospace vehicle non-destructive testing and evaluation as well as structural health monitoring. These guided waves possess the ability to travel long distances and exhibit a notable inclination to interact with existing damage. This work has numerically explored for the first time the use of a passive co-linear phased array to localise emission sources over a wide range of variables. Three localisation methods are explored, namely, reverse beamforming, wavefront curvature ranging, and hyperbolic lateration in a direction comparison without modelling transducers. It was shown that both reverse beamforming and wavefront curvature ranging could localise an emission with < 1% error in both range and bearing, while hyperbolic lateration was significantly worse. A relationship between bearing error and bearing was demonstrated, presenting the ability to develop new methods with correction factors that can localise emissions with even greater accuracy.
Modulating Entanglement Dynamics of Two V-type Atoms in Dissipative Cavity by Detuning, Weak Measurement and Reversal
Authors: Li Fuhua , Wang Jia , Zou Hong-Mei , Pan Qiying , Liu Chenya , Qu Zhuang 
Published: February 2024

Abstract

In this paper, how to modulate entanglement dynamics of two V-type atoms in dissipative cavity by detuning, weak measurement and weak measurement reversal is studied. The analytical solution of this model is obtained by solving Schrodinger Equation after diagonalizing Hamiltonian of dissipative cavity. It is discussed in detail how the entanglement dynamics is in uenced by cavityenvironment coupling, spontaneously generated interference (SGI) parameter, detuning between cavity with environment and weak measurement reversal. The results show that the entanglement dynamics of different initial states obviously depends on coupling, SGI parameter, detuning and reversing measurement strength. The stronger coupling, the smaller SGI parameter, the larger detuning and the bigger reversing measurement strength can all not only protect but also generate the entanglement, and the detuning is more effectively in tne strong coupling regime than the weak measurement reversal, which is more effectively than the SGI parameter. We also give corresponding physical interpretations.
PACS numbers: 03.65.Yz, 03.67.Lx, 42.50.-p, 42.50.Pq.
Tetracycline removal using NaIO4 activated by MnSO4: Design and optimization via response surface methodology
Authors: Yang Jingyi , Gao Yanjiao , Song Tiehong , Ye Jian , Zhao Lihong , Su Rui 
Published: February 2024

Abstract

The appearance of recalcitrant organic pollutants such as antibiotics in water bodies has gained a lot of attention owing to their adverse effects on organisms and humans. The current study aims to develop a novel approach to eliminate antibiotic tetracycline (TC) from a synthetic aqueous solution based on the advanced oxidation process triggered by MnSO4-catalyzed NaIO4. A single-factor experiment was performed to observe the impact of pH, NaIO4 concentration, and MnSO4 dosage on TC decomposition, and a three-factor, three-level response surface experiment with TC removal rate as the dependent variable was designed based on the range of factors determined from the single-factor experiment. The single-factor experiment revealed that the ranges of pH, NaIO4 concentration, and MnSO4 dosage need to be further optimized. ANOVA (analysis of variance) results showed that the data from the response surface experiment were consistent with the quadratic model with high R2 (0.9909), and the predicted values were very close to the actual values. After optimization by response surface methodology, the optimal condition obtained was pH = 6.7, [NaIO4] = 0.39 mM, and [MnSO4] = 0.12 mM, corresponding to a TC removal of 96.56%. This optimization condition was fully considered to save the dosage of the high-priced chemical NaIO4.
Structural-based Study to Identify the Repurposed Candidates
Against Bacterial Infections
Authors: Dey Debanjan , Kumar Anoop 
Published: February 2024

Background:::
Microbial infections are mostly caused by Gram-positive as
well as Gram-negative bacteria affecting millions of people worldwide. There is an urgent
need to explore existing molecules or discover new chemical entities (NCEs)
against bacterial infection.

Objective::
The main objective of the current investigation is to explore recently US-FDA-
approved drugs (2019-2023) against various targets of Gram-positive and Gram-negative
bacteria using high-performance computational studies.

Aim::
The current study aims to find out the potential drugs of recently US-FDA-approved
drugs as repurposing candidates against bacterial infections.

Methods::
The targets of Gram-positive and Gram-negative bacteria were identified using
literature studies whereas ligands were selected from the FDA-approved drug lists of
the last 5 years. Further, the drugs and targets were prepared through the LigPrep and
Protein Preparation Wizard modules of Schrödinger (release 2023-1) respectively. The
GlideDock and Desmond modules of Schrödinger were used for the molecular docking
study and molecular dynamics simulation respectively.

Results::
A total of 202 drugs were found in the FDA lists which were approved in the
last five years. Out of them, 77 drugs were selected for docking study based on their
properties. A total of 21 drugs have shown energetically favored binding conformation
of drugs in the active site of bacterial targets. The interaction of these drugs was studied
in detail using molecular dynamics (MD) simulation. The MD simulation results have
shown stable dynamic conformation of triclabendazole (anti-helminthic) with topoisomerase
II of gram-negative bacteria whereas solriamfetol (for obstructive sleep apnea)
has shown stable dynamic conformation in the active site of restriction endonuclease of
gram-positive bacteria.

Conclusion::
The identified drugs can be repurposed against Gram-positive and Gramnegative
bacterial infections. However, further experimental studies are required to confirm
their antibacterial potential.
Toxic Advanced Glycation End-Products-Dependent Alzheimer’s Disease-
Like Alternation in the Microtubule System
Authors: Ooi Hayahide , Koriyama Yoshiki 
Published: February 2024

Abstract:
Type 2 diabetes mellitus (T2DM) is a risk factor for Alzheimer's Disease (AD). However,
the detailed mechanism underlying T2DM-related AD remains unknown. In DM, many types
of advanced glycation end products (AGEs) are formed and accumulated. In our previous study,
we demonstrated that Glyceraldehyde (GA)-derived toxic Advanced Glycation End products (toxic
AGEs, TAGE) strongly showed cytotoxicity against neurons and induced similar alterations to
those observed in AD. Further, GA induced dysfunctional neurite outgrowth via TAGE-β-tubulin
aggregation, which resulted in the TAGE-dependent abnormal aggregation of β-tubulin and tau
phosphorylation. Herein, we provide a perspective on the possibility that T2DM increases the
probability of AD onset and accelerates its progression.
Timely Constructed and Enhanced Lining for Managing Extensive Deformations of Tunnel in Coal Stratum: A Case Study
Authors: Wang Yiming , Mansor Hazrina , David Thevaneyan Krishta 
Published: February 2024

Background
The Sanlian Tunnel case study exemplifies that even after implementing the initial support within the coal stratum, the surrounding rocks exhibited ongoing deformation devoid of stabilization indications. Addressing this issue calls for innovative control technologies that mitigate extensive deformations and redefine safe and sustainable coal stratum tunnel construction.

Methods
The field experiment was adopted to select the appropriate technical measures to control extensive deformations. Three experiment schemes were developed and applied to the construction. Scheme One was the enhanced initial support structure, and Scheme Two was the combined use of enhanced initial support structure, lengthened sidewall anchor rods and added steel pipe piles. Scheme Three was the “timely constructed and enhanced lining structure” proposed on the basis of Scheme Two, and the secondary lining was applied if the horizontal displacement exceeded 450mm. Then, field observations of displacements and stresses were implemented to evaluate the effectiveness of different experimental schemes in controlling extensive deformations.

Results
Scheme One and Two cannot control extensive deformations effectively, as the displacement of the initial support continued to increase with no sign of stabilization. Regarding Scheme Three, structural deformation progressively attained a state of stability around 80 days subsequent to the secondary lining construction. Additionally, the stress within the support structure remains stable below the permissible threshold, affirming the secure condition.

Conclusion
Emanating from the field monitoring results, it is evident that the suggested “timely constructed and enhanced lining structure” scheme control technology holds substantial promise for practical implementation in engineering scenarios.
The Comparative Study on the Mental Index and Panoramic Mandibular Index in Thai Osteoporotic, Osteopenic, and Non-osteoporotic Patients: A Cross-sectional Study
Authors: Talungchit Sineepat , Techapichetvanich Kusol , Rungsiyanont Sorasun 
Published: February 2024

Background
Osteoporosis is one of the clinical problems in the elderly. Many previous studies focused on the index obtained from dental radiography as an adjunctive tool, which is considered beneficial for the screening of osteoporosis.

Objective
The purpose of this study was to compare the Mental Index (MI) and Panoramic Mandibular Index (PMI) acquired from panoramic radiographs in osteoporotic, osteopenic, and non-osteoporotic patients.

Methods
This research was approved by the Ethics Committee for Human Research, Srinakharinwirot University (certification number SWUEC-061/2562E). This study compared 150 osteoporotic patients undergoing treatment at the HRH Princess Maha Chakri Sirindhorn Medical Center with age-sex matched to 150 non-osteoporotic patients undergoing dental treatment at the Dental Hospital, Faculty of Dentistry, Srinakharinwirot University, using digital panoramic radiographs. MI and PMI were collected and analyzed using an independent T-test and Pearson correlation.

Results
The mean age of the 300 participants in the study was 57.82±12.25 years, while the mean age of the osteoporotic and non-osteoporotic patients was 57.95±12.30 years and 57.69±12.19 years, respectively. The mean MI for osteoporotic patients and non-osteoporotic patients was 0.314±0.088 cm and 0.3840±0.073 cm, respectively. Similarly, the mean PMI for osteoporotic patients and non-osteoporotic patients was 0.302±0.092 and 0.342±0.064, respectively. A significant difference in MI and PMI was observed between osteoporotic and non-osteoporotic patients (p=0.00).

Conclusion
Osteoporosis has a statistically significant effect on MI and PMI (p<0.05).
The Impact of Recasting on the Bond Strength of Metal Ceramic Restorations
Authors: Elbishari Haitham , Nakhal Majdolin , Aljanahi May , Alsabeeha Nabeel 
Published: February 2024

Objective
The objective of this study is to evaluate the effect of recasting of Nickel Chromium (Ni-Cr) alloy on the bond strength of metal-ceramic restoration.

Materials and Methods
Forty-five samples fabricated from one Ni-Cr alloy were divided into three groups. Group 1 consisted of 100% fresh alloy; Group 2 consisted of 50% fresh alloy mixed with 50% alloy taken from sprue and button remnants of group 1 and group 3 consisted of 50% new alloy mixed with 50% alloy taken from sprue and button remnants of group 2. All samples were then bonded to a ceramic material. The bond strength of the Metal-Ceramic was then assessed using a 3-point bending test. The failure mode was investigated under a stereomicroscope and confirmed under scanning electron microscopy (SEM).

Results
Group 1 (100% fresh alloy) showed the highest bond strength amongst the other groups, while the lowest was recorded for group 3 (50% fresh alloy with 50% cast twice alloy). According to the International Organization for Standardization (ISO), the bond strength of fresh alloy and the group casted once attained the required level.

Conclusion
The outcome of this study indicates that the use of 100% fresh Ni-Cr base metal alloy yields the highest bond strength of metal ceramic restoration.
Predicting Commitment of Married Women based on Emotional Intimacy, Cognitive Flexibility, and Irrational Beliefs of Infertile Couples in Arak City in the 2021:A Cross-sectional Study
Authors: Vakilian Katayon , Ebrahimi Sara , Fouladvand Mohammad , Moslemi Azam , Najdi Nazila 
Published: February 2024

Aim
The present study aims to predict the commitment of infertile married women based on some cognitive and emotional variables.

Background
Marriage is the most important contract in every person's life. A marriage consists of several elements, such as commitment, marital satisfaction, and communication. In infertile couples, the values of their marriage and how much they want to maintain may be at risk.

Objectives
The present study wants to predict the commitment of infertile women based on emotional intimacy, cognitive flexibility, and irrational beliefs of infertile couples in Arak City in 2021.

Methods
The current research was conducted using a cross-sectional correlation method. Finally, 100 participants filled out the questionnaires. Convenience sampling was performed at Royan Infertility Clinic. The data were analyzed using t-test, Pearson and Chi-square tests.

Results
The results of the main outcome showed that higher levels of intimacy between couples lead to higher levels of commitment in married life (r=0.25, p=0.012). There is also an inverse relationship between couples' commitment and irrational beliefs in infertile couples, according to which more irrational beliefs lead to less commitment. However, there was no relationship between the commitment of infertile couples and psychological flexibility.

Conclusion
The marital commitment of infertile couples can be strengthened by increasing their intimacy and reducing their irrational beliefs.
Evaluating the Effect of Underlying Pulmonary Disease on the Clinical Outcome and survival among Patients with COVID-19: Using Propensity Score Matching
Authors: Safari Malihe , Ghadamgahi Fatemeh , Faradmal Javad , Bashirian Saeid , Soltanian Ali Reza , Khazaei Salman , Roshanaei Ghodratollah 
Published: February 2024

Background
Coronavirus (COVID-19) is a life-threatening factor throughout the world. Having an underlying disease among the patients with this disease diminishes the clinical effectiveness and increases their mortality rate. Hence, the study was carried out to compare the clinical outcomes in patients with COVID-19 with and without pulmonary disease using propensity score matching.

Methods
This case-control study was conducted on 299 COVID-19 patients with pulmonary disease (case group) and 299 COVID-19 patients without pulmonary diseases (control group). Matching the patients in the case and control groups was done using propensity score matching. Logistic regression was used to assess the effect of factors on the patient's clinical outcome (recovery-death), and the Cox model was used to determine the factors affecting patient survival. Data were analyzed in R software.

Results
The mean (SD) of the patients' age in the case and control groups was 65.49 (15.55) and 65.67 (15.55), respectively. The results of the logistic regression model showed that age, pulmonary disease, nausea, and blood oxygen affect patient death. The results of the Cox proportional-hazards model indicated that the variables of age, blood oxygen, and pulmonary had a significant effect on patient survival.

Conclusion
Given the high mortality rate among patients with COVID-19 and chronic pulmonary disease, these patients are considered a high-risk group and need special care.