bluuebunny/crossref_metadata_2025_split huggingface dataset:
Evinacumab (Evkeeza)
Authors: CADTH  
Published: February 2024

CADTH recommends that Evkeeza be reimbursed by public drug plans as an adjunct to diet and other low-density lipoprotein cholesterol (LDL-C)–lowering therapies for the treatment of adult and pediatric patients aged 5 years and older with homozygous familial hypercholesterolemia (HoFH) if certain conditions are met.
Evkeeza should only be covered to treat patients aged 5 years and older with a diagnosis of HoFH and extremely high levels of LDL-C (sometimes referred to as bad cholesterol) despite receiving other cholesterol-lowering treatments.
Evkeeza should only be reimbursed if prescribed by specialists with experience in managing HoFH and if the cost of Evkeeza is reduced. Evkeeza may only be prescribed for 24 weeks the first time it is used. To continue treatment with Evkeeza longer than 6 months, the treating physician must provide proof that the patient is responding to treatment, defined as reduction in LDL-C levels.
Single-blind test of nine methane-sensing satellite systems from three continents
Authors: Sherwin Evan D. , El Abbadi Sahar H. , Burdeau Philippine M. , Zhang Zhan , Chen Zhenlin , Rutherford Jeffrey S. , Chen Yuanlei , Brandt Adam R. 
Published: February 2024

Abstract. Satellite-based remote sensing enables detection and mitigation of large point sources of climate-warming methane. These satellites will have the greatest impact if stakeholders have a clear-eyed assessment of their capabilities. We performed a single-blind test of nine methane-sensing satellites from three continents and five countries, including both commercial and government satellites. Over 2 months, we conducted 82 controlled methane releases during satellite overpasses. Six teams analyzed the resulting data, producing 134 estimates of methane emissions. Of these, 80 (58 %) were correctly identified, with 46 true positive detections (34 %) and 34 true negative non-detections (25 %). There were 41 false negatives, in which teams missed a true emission, and 0 false positives, in which teams incorrectly claimed methane was present. All eight satellites that were given a nonzero emission detected methane at least once, including the first single-blind evaluation of the EnMAP, Gaofen 5, and Ziyuan 1 systems. In percent terms, quantification error across all satellites and teams is similar to aircraft-based methane remote sensing systems, with 55 % of mean estimates falling within ±50 % of the metered value. Although teams correctly detected emissions as low as 0.03 metric tons of methane per hour, it is unclear whether detection performance in this test is representative of real-world field performance. Full retrieval fields submitted by all teams suggest that in some cases it may be difficult to distinguish true emissions from background artifacts without a known source location. Cloud interference is significant and appears to vary across teams and satellites. This work confirms the basic efficacy of the tested satellite systems in detecting and quantifying methane, providing additional insight into detection limits and informing experimental design for future satellite-focused controlled methane release testing campaigns.
Flexural isostatic response of continental-scale deltas to climatically driven sea level changes
Authors: Polanco Sara , Blum Mike , Salles Tristan , Frederick Bruce C. , Farrington Rebecca , Ding Xuesong , Mather Ben , Mallard Claire , Moresi Louis 
Published: February 2024

Abstract. The interplay between climate-forced sea level change, erosional and depositional processes, and flexural isostasy in deep time on passive margin deltas remains poorly understood. We performed a series of conceptual simulations to investigate flexural isostatic responses to high-frequency fluctuations in water and sediment load associated with climatically driven sea level changes. We model a large drainage basin that discharges to a continental margin and produces a large deltaic depocenter, then prescribe synthetic and climatic-driven sea level curves of different frequencies to assess flexural response. Results show that flexural isostatic responses are bidirectional over 100–1000 kyr timescales and are in sync with the magnitude, frequency, and direction of sea level fluctuations and that isostatic adjustments play an important role in driving along-strike and cross-shelf river mouth migration and sediment accumulation. Our findings demonstrate that climate-forced sea level changes produce a feedback mechanism that results in self-sustaining creation of accommodation into which sediment is deposited and plays a major role in delta morphology and stratigraphic architecture.
Co-RISK: a tool to co-create impactful university–industry projects for natural hazard risk mitigation
Authors: Hillier John K. , van Meeteren Michiel 
Published: February 2024

Abstract. Translation of geoscience research into tangible changes, such as modified decisions, processes, or policy, in the wider world is an important yet notably difficult process. Illustratively, university-based scientists and professionals work on different timescales, seek different insights, and may have a substantial cognitive distance between them. The work on Co-RISK reported in this paper is motivated by an ongoing need for mechanisms to aid this translation process. Co-RISK is an accessible (i.e. open access, paper based, zero cost) toolkit for use by stakeholder groups within workshops. Co-RISK has been developed to aid the co-creation of collaborative inter-organisational projects to translate risk-related science into modified actions. It is shaped to avoid adding to a proliferation in increasingly complex frameworks for assessing natural hazard risk and is given a robust basis by incorporating paradox theory from organisation studies, which deal with navigating the genuine tensions between industry and research organisations that stem from their differing roles. Specifically designed to ameliorate the organisational paradox, a Co-RISK workshop draws up “maps” including key stakeholders (e.g. regulator, insurer, university) and their positionality (e.g. barriers, concerns, motivations) and identifies exactly the points where science might modify actions. Ultimately a Co-RISK workshop drafts simple and tailored project-specific frameworks that span from climate to hazard, to risk, to implications of that risk (e.g. solvency). The action research approach used to design Co-RISK, its implementation in a trial session for the insurance sector, and its intellectual contribution are described and evaluated. The initial Co-RISK workshop was well received so it is envisaged to be applicable to other sectors (i.e. transport infrastructure, utilities, government). Joint endeavours enabled by Co-RISK could fulfil the genuine need to quickly convert the latest insights from environmental research into real-world climate change adaptation strategies.
The Effect of Health Education Using Audiovisuals on The Knowledge of Adolescent Girls about Breast Self-Examination (BSE)
Authors: Okty Zull Fanny Aesza , Tiara Carolin Bunga , Azzahroh Putri 
Published: February 2024

Cancer is a non-communicable disease with the second-largest death rate in the world. Breast cancer is one of the main diseases treated by palliative care services. Breast cancer is the most common cancer among women in the world. Early detection is a very important first step to find out early the presence of tumors or lumps in the breast to reduce the death rate due to cancer. The advantage of early detection of breast cancer is beneficial to increase the chances of life expectancy in women with breast cancer. Almost 85% of disorders or lumps are found by the patient through proper examination. In addition, BSE is the easiest, fastest, cheapest, and simplest method that can detect breast cancer early. Knowing the Effect of Health Education Using Audio Visual Media on Adolescent Girls' Knowledge about BSE at SMAN 10 Tangerang Regency Banten 2023. The research design used was quasi-experimental research with a one-group pretest-posttest design approach. The population used in this study was class X adolescent girls at SMAN 10 Tangerang Regency totaling 155 people. The number of samples taken was 30 samples obtained through the Proportionate Stratified Random Sampling technique. Data were collected using a questionnaire. Data analysis was done by Paired T Test. The results of univariate analysis before conducting health education using audio-visual video exposure were 10.67, while the average knowledge of adolescent girls increased after health education to 15.60. The results of bivariate analysis with paired sample t-test P value = 0.001 means that there is an effect of counseling with audiovisual media on increasing the knowledge of adolescent girls about breast self-examination. Using audiovisual media to increase knowledge about breast self-examination (BSE) for early detection of cervical cancer.
Analisi dei fattori incidenti sull’opposizione della popolazione alla donazione d’organo: una revisione integrativa della letteratura
Authors: Cartechini Valentina , Gatti Chiara , Bacaloni Simona , Carpano Sabrina , Grillo Claudio , Fiorentini Rita 
Published: February 2024

BACKGROUND: Fonti istituzionali mostrano ad oggi un cospicuo numero di opposizioni alla donazione, una lenta crescita di iscrizioni al registro dei donatori e un gap tra donatori disponibili e riceventi in lista di attesa.
OBIETTIVI: Valutare i fattori che portano la popolazione nazionale ed internazionale a non acconsentire alla donazione degli organi.
METODI: È stata condotta una revisione integrativa secondo la metodologia Whittemore & Knafl durante il mese di Agosto 2022 presso PubMed. Gli articoli sono stati successivamente selezionati secondo criteri di inclusione ed esclusione precedentemente stabiliti.
RISULTATI: Al termine del processo di selezione sono stati inclusi 16 studi. Alla base della decisione di acconsentire alla donazione degli organi sia in vita sia in caso di morte di un familiare vi è l’influenza di diversi fattori, in particolare il sistema di consenso, la cultura, la religione, l’attività dei professionisti sanitari in particolare l’infermiere e la conoscenza del singolo in materia di trapianto e donazione.
CONCLUSIONI: Per acquisire consenso nei confronti della donazione d’organo dovrebbe essere previsto un intervento olistico rivolto sia alla popolazione generale che ai professionisti sanitari, pianificando interventi educativi centrati sul target preso in considerazione.
Combined laparoscopic and endoscopic method for foreign body removal from descending colon: A case report
Authors: Che Ghazali Khairunnisa , Yaacob Huzairi , Mohamed Sidek Ahmad Shanwani 
Published: February 2024

BACKGROUND
The majority of published reports on foreign bodies (FBs) involve the rectum and applied a transanal retrieval. Usually, patients with FB above the rectum are subjected to laparotomy for removal. Here, we illustrate the case of a man with an FB that had migrated into the descending colon, and its successful removal via a laparoscopic approach.
CASE SUMMARY
A 43-year-old man, who had the habit of FB insertion into his anus to aid defecation, presented upon experience of such an FB slipping through and migrating upward to the distal colon. Plain abdominal radiograph revealed a bottle-shaped FB, positioned in the left iliac fossa region. The FB was successfully removed via a laparoscopic-assisted procedure in which we combined diagnostic laparoscopic and endoscopic techniques during surgery. The patient was monitored for 2 d postoperatively and subsequently discharged home.
CONCLUSION
A minimally invasive approach should be adopted to aid extraction of colorectal FB as it is effective and safe.
Transformasi Pemerintahan Digital: Tantangan dalam Perkembangan Sistem Pemerintahan Berbasis Elektronik (SPBE) di Indonesia
Authors: Kencono Bagas Dwi , Putri Honi Hari , Handoko Tyas Wida 
Published: February 2024

Penelitian ini bertujuan untuk menganalisis perkembangan implementasi SPBE di Indonesia yang berfokus dalam Indonesia yang berfokus dalam mengidentifikasi faktor-faktor yang menghambat implementasi SPBE dan memberikan rekomendasi terkait transformasi digital guna meningkatkan penerapan SPBE di Indonesia. Penelitian ini menggunakan pendekatan kualitatif dengan teknik pengumpulan data berupa studi literatur. Data yang diperoleh dianalisis dengan menggunakan teknik analisis deskriptif ideal type contrast context. Hasil analisis menunjukan beberapa faktor penghambat dan tantangan dalam implementasi SPBE di Indonesia, yaitu permasalahan mengenai kurangnya ketersediaan infrastruktur TIK, permasalahan mengenai pengaruh signifikan suatu kepemimpinan, serta permasalahan mengenai budaya dan lingkungan kerja. Berdasarkan permasalahan tersebut terdapat beberapa rekomendasi kebijakan yang dapat pemerintah pertimbangkan, yakni (1) pemerintah patut memperluas aksesibilitas dan meningkatkan infrastruktur digital di Indonesia sebagai landasan pemerataan SPBE di Indonesia, (2) pemerintah pusat patut memberikan pendampingan dan pelatihan kepada setiap pemerintah daerah dan aparatur sipil negara (ASN) mengenai cara menggunakan dan memanfaatkan SPBE dalam sistem pemerintahan untuk memberikan pelayanan publik yang optimal, (3) pemerintah patut mendukung dan memprioritaskan integrasi Pusat Data Nasional yang akan menghimpun seluruh data daerah, kementerian, dan lembaga secara nasional dalam satu Big Data.
Strategic Management Model for Legal Entity State Universities Toward a World Class University (WCU) Through a Strategic Intelligence Approach
Authors: Nasution Muhammad Arifin , Revida Erika , Humaizi  , Kusmanto Heri 
Published: February 2024

Background: In the present era of global industrialization, universities are facing an increasing challenge to nurture human resources that are capable of thriving and excelling in global competition. Universitas Sumatera Utara (USU) serves as one of the largest universities in Indonesia and is counted among the 16 Legal Entity State Universities (LESU). As part of the strategic plan outlined by the relevant ministry, there is a priority program that encourages Indonesian universities to achieve the World Class University (WCU) predicate. This scenario necessitates an enhancement of academic reputation Internationally. Method: An explanatory with a quantitative approach was used, and the data were analyzed using Structural Equation Models (SEM). Results: Consequently, the result showed that strategic intelligence significantly and positively played a role in accelerating the influence of strategic management on the performance of the university in achieving WCU predicate. Typically, strategic management consists of strategy formulation, implementation, evaluation, and control. Conclusion: Strategic intelligence, including the upstream system, input quality, leadership system quality, and sound policy guidance, could be recommended as an appropriate approach to strengthen the capacity and expedite the achievement of USU's targets for the WCU predicate.
STRATEGI PENGEMBANGAN USAHA SIRUP KALAMANSI MELALUI PROGRAM ONE VILLAGE ONE PRODUCT (OVOP) DI KOTA BENGKULU
Authors: Mardiati Sari Dian , Sureta Nurdina 
Published: February 2024

The purpose of this research is to find out the strategy to improve economic value of Kalamansi syrup in the Bengkulu City. This research is descriptive research . Data analysis method used is descriptive analysis and SWOT analysis. Based on the results of the analysis of the data obtained results that the strategy improvement of Kalamansi syrup in the Bengkulu City : (a) support development of more modern processing technology; (b) Conducting orange of kalamansi to take care of the continuity of production; (c) Cooperation between worker in pricing product; (d) Program reinforcement and development micro and small industries; (e) Support capital employed of financial institution; (f) Improve product promotion intensity on local media and national; and (g) Network marketing.
INOVASI PELAYANAN PUBLIK (STUDI PADA LEMBAGA LEMBAGA LAYANAN PENDIDIKAN TINGGI WILAYAH II)
Authors: Agraini Dian 
Published: February 2024

Menindaklanjuti amanat UU Nomor 25 Tahun 2009 tentang Pelayanan Publik dan Peraturan Menteri Pendayagunaan Aparatur Negara dan Reformasi Birokrasi Nomor 15 Tahun 2014 tentang Pedoman Standar Pelayanan, LLDIKTI Wilayah II telah menetapkan Standar Pelayanan serta maklumat pelayanan LLDIKTI Wilayah II dengan memperhatikan kebutuhan pelayanan dari stakeholder dan disesuaikan dengan sarana dan prasarana serta kemampuan dari pelaksana pada LLDIKTI Wilayah II. Standar Pelayanan adalah tolok ukur yang digunakan sebagai pedoman penyelenggaraan pelayanan dan acuan penilaian kualitas pelayanan sebagai kewajiban dan janji penyelenggara kepada masyarakat dalam rangka pelayanan yang berkualitas, cepat, mudah, terjangkau, dan terukur. Berdasarkan hal tersebut maka ditetapkanlah Standar Pelayanan LLDIKTI Wilayah II yang terdiri dari 52 (lima puluh dua) jenis standar pelayanan meliputi persyaratan, prosedur, waktu, biaya, produk pelayanan dan penanganan pengaduan saran dan masukan sebagai panduan dalam pemberian pelayanan bagi stakeholder yang membutuhkan. Sebelumnya, administrasi pelayanan di LLDIKTI melaksanakan pelayanan manual yaitu secara tatap muka dan pengumpulan berkas (hardcopy). Hal ini tentu saja menimbulkan masalah dalam hal jarak dan waktu. Sebagai contoh dalam melakukan pengurusan jenjang biasanya seorang dosen akan melengkapi berkas persyaratan dan dikumpulkan untuk kemudian diproses oleh Petugas LLDIKTI Wilayah II. Sebagai bentuk penerapan layanan digital LLDIKTI II mulai melakukan perubahan agar kendala jarak dan waktu dapat diminimalisir dengan memberikan pelayanan secara online. Berdasarkan latar belakang tersebut Penulis tertarik untuk meneliti bagaimana Inovasi pelayanan public serta menganalisasi apa saja factor-faktor yang mempengaruhi proses tersebut. Penelitian ini menggunakan metode penelitian penelitian deskriptif kualitatif melalui hasil observasi dan wawancara. Pengambilan data akan dilakukan dengan melibatkan LLDIKTI Wilayah II dalam proses pelayanan public serta pengguna layanan yaitu Perguruan Tinggi, Dosen dan Tenaga Kependidikan. Adapun penekanan konsep penelitian disesuaikan dengan lima karakteristik yang digunakan untuk mengevaluasi kualitas pelayanan, yaitu : Bukti langsung (tangibles), kehandalan (reliability), daya tanggap (responsiveness), jaminan (assurance), serta empati (emphaty) yang terjadi dalam Inovasi Pelayanan Publik Di LLDIKTI II menunjukan bahwa telah dilaksanakan secara optimal walaupun masih mengalami kendala karena factor oleh kurangnya sumber daya manusia baik secara kualitas dan kuantitas, dan rendahnya penyerapan informasi dari LLDIKTI II kepada stakeholder. .
Infestation of White Waxy Scale on Coffea arabica in Southwestern Ethiopia
Authors: Shimales Tamiru 
Published: February 2024

Over 49 coffee insect species reported in Ethiopia. However, mealybugs and whitefly are the pests currently recorded in Ethiopia. Ceroplastes brevicauda (Hemiptera: Coccidae) is one of potentially important coffee pest. From assessed coffee trees around 96% and 27% mean infestation of bearing branch and dried branch due to the insect recorded, respectively from coffee hybrids. Coffee berry disease resistant cultivars were exhibit cross-susceptibility against white waxy scale. The white waxy scale although affecting Acacia abyssinica shade tree. Cultural pest management such as pruning infested coffee branches and rubbing the waxy scale by using alcohol is best fits in integrated pest management which usually recommended for coffee producers. Therefore, future research works should be focused on characterizing and identifying the natural enemies and screening insecticides as one management of pest management options.
Respons samhälle
Authors: Arenius Josefine 
Published: February 2024

Varje nummer av HYBRID innehåller, förutom originalartiklar, också tre beställda responser: en från någon verksam inom området akademi, en från någon verksam inom området kyrka och en från någon verksam inom området samhälle. Dessa responser är utformade som kortfattade reflektioner över något ur numrets artiklar som har särskild relevans för respektive område.
Analysis of Needs for the Application of Differentiated Learning in Class X Natural and Social Sciences Subjects at SMKN 1 Bengkulu City
Authors: Rosni Rosni 
Published: February 2024

The research aims to find out how the implementation of learning is differentiated in class X natural and social sciences at SMKN 1 Bengkulu City even semester of the 2022-2023 academic year. In this study, a qualitative approach is combined with a descriptive way of analysis. The study's findings are displayed in the form of exposure. The data collection methods used in this study were observation, interviewing, and documentation. There were 5 participants in the study at SMKN 1 Bengkulu City. This study's main objective is to describe how differentiated learning can be implemented in the solar system's natural and social sciences chapter. In the first phase, learning readiness, interests, and learning profiles are used to map students' learning needs. The second phase is to plan, which entails developing a differentiated learning strategy employing three types of differentiation: content, process, and product. The third phase involves implementing differentiated learning in accordance with the created learning implementation plan, and the fourth phase involves evaluation and reflection with the goal of being able to perceive the drawbacks and benefits as material for the next learning improvement. Researchers are interested in the effects of differentiated learning implementation on classroom learning activities once it has been put into place. From the results of the interviews, it was concluded that 85% of the science teachers at SMKN 1 Bengkulu City agreed, the school management team 100% agreed, and 98% of students agreed to apply differentiated learning to the science subject in class X SMKN 1 Bengkulu City.
STRATEGI KOMUNIKASI PARADOX COFFEE AND ROASTERY DALAM MEMBANGUN BRAND IMAGE MELALUI MEDIA SOSIAL INSTAGRAM
Authors: Mangngi Dwiputra mone , Silvana Mandaru  , Pietriani  
Published: February 2024

The communication strategy in building the company's brand image is part of the demands of PR practitioners to adapt to digitalization developments and utilize new media. In responding to these demands, Paradox Coffee and Roastery is present in the community and responds to these demands based on what the community needs. This is done by publishing informative and educational content via the Instagram account @paradox.creative with the aim of influencing stakeholders to follow and visit their coffee shop. The purpose of this study was to determine the communication strategy of Paradox Coffee and Roastery in building a brand image through Instagram social media. The theory used in this study is social media engagement theory and the concept of communication strategy. This study uses a type of qualitative research. The results of this research consist of 4 strategy stages, including: 1) Stage of getting targets and opportunities, 2) Stage of content creation, 3) Stage of Audience Engagement, 4) Stage of evaluating the program being run, Through the Instagram account Paradox Coffee and Roastery creates and packages informative and educational content through Instagram feeds and stories which contain information and engagement content so that it gets intense interaction when the publication is made, the strategy chosen by Paradox Coffee and Roastery can increase its positive image in the community as the first local coffeeshop to come with a modern and minimalist concept.

Keywords: Communication Strategy, Publication, Social Media, Instagram.