bluuebunny/crossref_metadata_2025_split huggingface dataset:
Examining MC Edo Pikin’s Art and Social Media Theatre Persona as Prototype for Sustainable Living through Creativepreneurship
Authors: Osakue Stevenson Omoera  , Divine Sheriff Uchenna Joe  
Published: February 2025

The growing indices of poverty in Africa are alarming, thus necessitating an increased quest for creative means to change the tide. Adopting the Creative Imitation Theory (CIT), the study uses historicocritical, content analysis, key person interview (KPI) and direct observation methods to investigate the potential of harnessing creativepreneurship among youths in job or wealth creation and self-empowerment. The researchers use a Nigerian comedian and social media celebrity, MC Edo Pikin as a case study. The article analyses how social media could be leveraged by a creative artist for self-realization, social impact and economic emancipation. It unpacks how MC Edo Pikin through the instrumentality of his art as a skit-maker cum comedian, satirizes emerging socio-political, socio-economic, and socio-cultural issues in Nigeria, yet maximizes motifs, creative branding, and innovation for entertainment and economic empowerment. The study argues that by embracing creativepreneurship by Nigerian and African youths, a route to exiting excruciating poverty would have been found and sustained outside waiting for a 'government job' remit. However, the study identifies possible limitations to the actualization of creativepreneurship, including a wrong application of creativity, non-commitment to personal skills development, inconsistency of vision, and lack of or/non-implementation of clear policy directions for the cultural and creative industries (CCIs) in Nigeria. Given this, the study suggests that a well-articulated interface between social media and creativepreneurship offers a realistic alternative to human capital development, revenue generation, sustainable living, and poverty eradication.
Mapping the language-in-identity configuration in Hong Kong today
Authors: GUO Yufei 
Published: February 2025

Abstract

This study explores the cognitive mechanisms through which language is progressively engaged in the flow of identity construction under power relations, based on an empirical study on Hong Kong’s media discourse from 2017 to 2022. Drawing on the concepts of collective identity and indexicality, we analyze the indexical meanings of Cantonese, Putonghua, Simplified Chinese characters and Traditional Chinese characters, uncovering four modalities within Hong Kong’s language-in-identity landscape amid changing sociopolitical conditions. The findings highlight the nuances and dynamics of Hong Kong’s language-in-identity process: while Putonghua and simplified characters are commonly associated with resistance identity against Mainland China, there is a notable trend of Putonghua being increasingly linked to national identity. Furthermore, Cantonese and traditional characters carry identity connotations at local, regional and national levels, setting the stage for their further exploitation in conscious or unconscious identity work for various purposes. In terms of theoretical contributions to the broader fields of language and identity research, this study demonstrates that a “successful” integration of language issues into identity work relies heavily on reprocessing certain language ideologies that are already embedded within the society in question.
Influenza A(H5N1) Viruses Isolated From Dairy Cattle Demonstrate High Virulence in Laboratory Models, but Retain Avian Virus-like Properties
Authors: Webby Richard , Fabrizio Thomas , Kandeil Ahmed , Harrington Walter , Jones Jeremy , Jeevan Trushar , Andreev Konstantin , seiler Jon , Fogo Jonathan , Davis Morgan , Crumpton Jeri-Carol , Franks John , DeBeauchamp Jennifer , Vogel Peter , Daniels C. Scanlon , Poulson Rebecca , Bowman Andrew , Govorkova Elena 
Published: February 2025

Abstract

In March 2024, clade 2.3.4.4b highly pathogenic avian influenza A(H5N1) viruses were first detected in U.S. dairy cattle. Similar viruses have since caused 66 zoonotic human infections. To assess changes to zoonotic potential, we characterized A(H5N1) clade 2.3.4.4b viruses isolated from cows’ milk and birds. Bovine-derived viruses were lethal in mice and ferrets and transmitted to direct but not airborne contact ferrets. All viruses replicated in human bronchial epithelial cells despite preferentially binding avian virus-like receptors. The bovine-derived viruses remained susceptible to FDA-approved antivirals and were neutralized by sera from ferrets vaccinated with WHO CVVs or humans vaccinated with clade 2.3.4.4c vaccine. While 2.3.4.4b viruses induce severe disease in mammalian models, they retain many avian virus-like characteristics. Combined, we conclude that the risk of contemporary bovine-derived viruses to humans not in contact with affected animals is low. However, heightened vigilance remains essential to promptly detect and respond to any changes.
Asymmetric Morphodynamics of the Wadden Sea
Authors: Leiva Diego Pineda , Lorenz Marvin , Kösters Frank , Winter Christian , Lepper Robert 
Published: February 2025

Abstract

Shallow coastal systems with tidal flats and barrier islands are valuable assets to coastal protection and unique habitats for thriving biodiversity. Sea level rise threatens to diminish these systems unless sediment accretion compensates submergence. To quantify dynamics, an observed geomorphologic time-series was created and assessed over three decades for the world’s largest channel-shoal system, the Wadden Sea. We found that (i) accretion-erosion was asymmetric from deep to shallow, (ii) noteworthy topographic steepening occurred, and (iii) the morphological evolution was systematic across tidal basins. Peak accretion was observed below the tidal low and above tidal high water, while the greatest erosion was found at intermediate subtidal elevations. Most intertidal areas accreted proportional or faster than sea level rise and accretion was prominent at the channel-flat and flat-marsh interfaces. The simultaneous deepening of tidal channels leads to topographic steepening. Overall, the current net sediment import of the Wadden Sea is 19.7 Mm³/yr.
HIF1α Integrates Lipogenic FASN and Glycolytic GLUT3 to Overcome intratumor Oxidative and Hypoxic Stress for Colorectal Cancer Metastasis
Authors: Wang Yunyi , Wei Yuanyi , Bailey Christopher , Peng Gong , Zhang Peng , Wang Yin , Liu Yan 
Published: February 2025

Abstract

Background
Colorectal carcinoma (CRC) is the third most prevalent cancer worldwide and a leading cause of cancer-related mortality, primarily due to its high propensity for metastasis. Despite therapeutic advancements, the molecular mechanisms by which intratumor hypoxia and oxidative stress contribute to malignancy remain poorly understood.
Methods
Gene expression profiles were analyzed across various stages of CRC (T1–T4) and metastatic CRC (mCRC). The role of hypoxia-inducible factor 1 alpha (HIF1α) was investigated in CRC cell lines and in vivo models to evaluate its impact on local tumor growth and lung metastasis. Mechanistic studies focused on HIF1α-mediated regulation of fatty acid synthase (FASN) and GLUT3 in the tumor microenvironment to promote CRC distant metastasis. Therapeutic targeting of HIF1α was assessed using echinomycin encapsulated in lipid nanoparticles.
Results
HIF1α was identified as a critical regulator enabling tumors to overcome intratumoral stress and proliferate in hypoxic regions. Activation of the IGF1/Insulin-AKT-mTOR pathway led to HIF1α accumulation, which, in turn, upregulated FASN and GLUT3 expression, mitigating oxidative and hypoxic stress. Elevated HIF1α levels were positively correlated with increased NRF2 activity in CRC cells, contributing to malignancy and metastatic potential. Targeting the HIF1α-FASN/GLUT3 axis with echinomycin-loaded lipid nanoparticles effectively inhibited tumor growth and abrogated lung metastases in preclinical models.
Conclusions
The IGF1/Insulin-HIF1α-FASN/GLUT3 signaling axis is a key driver of CRC progression and lung metastasis by counteracting oxidative stress and hypoxia. Therapeutic inhibition of HIF1α offers promising potential for mitigating CRC malignancy and preventing metastasis.
Machine learning assisted interfacial catalysis of metal-oxide nanocatalysts in CO2 hydrogenation
Authors: Zhang Zhenhua , Ren Dandan , Hong Mei , Li Ruiying , Zhou Yuwei , Li Chenke , Ding Jieqiong , Wang Fei , Liu Xingchen , Huang Weixin , Wen Xiao-Dong 
Published: February 2025

Abstract

Understanding the structure-property relationship is of pivotal importance for the rational design of efficient solid catalysts, while this process is seriously blocked by their structural complexity. Here, we have developed a machine learning (ML) assisted strategy to deeply decouple the interfacial catalysis of metal-oxide nanocatalysts in CO2 hydrogenation by combining experimental and theoretical results with ML algorithm. Using representative Pd/CeO2 catalysts selected on basis of an experimental data-driven ML model, the matched experimental and ML-predicted results demonstrate that, besides surface oxygen vacancies of the support that are responsible for the adsorption and activation of CO2, the catalytic activity and CO selectivity are determined by the H spillover and hydrogenation properties and the binding strength of CO intermediate, respectively, both tightly relevant to the nature of supported metals. Further feature-importance analysis indicates that the d states’ center of supported metals, associated with the intrinsic nature of metal atoms and the metal-support interactions, acts as the most important factor governing the catalytic performance. This work greatly deepens the fundamental understanding of metal-oxide NCs in CO2 hydrogenation and innovatively pens up a new paradigm for catalytically fundamental studies to unravel the complex nature of heterogeneous catalysis.
Bidirectional EV Charging Allows Deep Decarbonisation of the UK Residential Sector
Authors: Berkes Anaïs , Reiner David , Keshav Srinivasan 
Published: February 2025

Abstract

Charging an electric vehicle (EV) from a residential solar photovoltaic (PV) system, aided by the EV being parked at home for some or all of the time, substantially reduces a household's monthly electricity bill, its cost for an energy storage system, and its CO2 emissions. These benefits improve dramatically with bidirectional charging, where the EV is allowed to discharge electrical energy. We find that, at the household-level, each individual element significantly reduces both costs and emissions and their simultaneous adoption has substantial additional benefits. For example, a household with a PV system and an electric vehicle used only for occasional commutes emits up to 66% less CO2 than a household that has neither. At the national level, 90% adoption of bidirectional residential EV charging could reduce the UK's CO2 emissions by nearly 55%. Therefore, we urge policymakers and regulators to encourage the rapid adoption of bidirectional EV charging from residential solar PV.
Evolutionary Algorithms for Physician Scheduling Problem with Emphasis on Workload Balancing
Authors: Yakoubi Ghada , Ahabchane Chahid , Layeb Safa Bhar 
Published: February 2025

Abstract

Disruptions coupled with unpredictable patient arrival rates create a stressful work environment for physicians, potentially leading to negative outcomes such as burnout and turnover, making it essential to manage physicians' workloads effectively to ensure better working conditions and enhanced patient safety. This study tackled the physician scheduling problem, where workload balance was the key challenge and aiming to distribute shifts among physicians equitably. By integrating evolutionary algorithms with local search techniques, the goal is to improve the working conditions and reduce stress among physicians.
A comparative study, with experiments conducted on a real-life case study within a public hospital in Canada, was performed to evaluate the effect of workload balance and fairness on patient care where different scenarios were tackled. This study highlights the importance of prioritizing both workload balance and fairness in emergency departments, demonstrating their positive impact on physician well-being without negatively affecting the number of untreated patients.
Predictive Factors for Preterm Birth by the Evaluation of Uterine Cervical Stiffness During Pregnancy Using Shear Wave Elastography
Authors: George Reeba , Rehman Anam , Ashraf Ramsha , Khan Nishmal Umer , Fatima Areej , Ali Babar , Akilimali Aymar , Nadeem Zonaina , Hanan Abdul , Naeem Muhammad 
Published: February 2025

Abstract

Background and Aims: The uterine cervix plays a crucial role in ensuring a pregnancy reaches full term for the complete development of the fetus. However, as pregnancy nears its end, the cervix undergoes significant softening, shortening, and dilation to facilitate delivery. Spontaneous preterm birth, the leading cause of death in children under 5 globally, can occur through various pathways, all converging on premature changes in the cervix as the final common step leading to delivery.
Methods: This cross-sectional analytical study was conducted in the Radiology Department of Chaudhry Muhammad Akram Teaching and Research Hospital, Lahore, Punjab, Pakistan. The sample size comprised 111 participants, selected through probability sampling. The study focused on pregnant females aged 18 to 40. The inclusion criteria encompassed pregnant women within the specified age range, while exclusion criteria involved uncooperative patients and females presenting with other pathologies. The ECHOSENS FibroScan 402 Sono elastography machine, equipped with a probe frequency range of 3 to 12 MHz for both Transabdominal and Transvaginal assessments, was employed for data collection. This comprehensive methodology aimed to systematically investigate and analyze uterine cervical stiffness during pregnancy using advanced elastography technology.
Results: Our study involved 111 participants, with an average age of 29.6 years and a median parity of 2. Examining the cervical characteristics, we found that the mean cervical length was 35.1 mm with a standard deviation of 8.2 mm, while the mean Shearwave Elastography was 2.3 kPa with a standard deviation of 0.6 kPa. Drawing from our sample of 111 observations, a robust correlation analysis revealed a compelling relationship between Cervical Length and Shearwave Elastography. The correlation coefficient of .557, coupled with a highly significant p-value of .000, underscores a strong and consistent monotonic trend.
Conclusion: In conclusion, our study reinforces the clinical significance of elastography ultrasound in assessing cervical stiffness during pregnancy.
Current Oceanic CO2 Uptake: The Priming Effect of the Marine Carbon Pumps
Authors: Koeve Wolfgang , Landolfi Angela , Oschlies Andreas , Frenger Ivy 
Published: February 2025

Abstract

The impact of marine biological carbon pumps (BCPs) on atmospheric pCO2 (pCO2atm) is considered to be very important in the context of long-term climate swings (e.g. glacial-interglacial). However, under the current climate change transient their impact is considered low and difficult to detect, being masked by the massive invasion of anthropogenic CO2 (Canth) into the ocean. Here we show and quantify how BCPs prime the ocean for a significantly elevated Canth uptake, compared to a hypothetically abiotic ocean, through their control on the preindustrial CO2-buffer capacity. Using an Earth System model of intermediate complexity, run in model variants where individual marine carbon pumps have been turned off, we find strong and opposing effects from the soft-tissue (+194 Pg) and the CaCO3 counter pumps (-61 Pg) on Canth uptake between years 1765 and 2100 for a high emission scenario. This “priming effect” from both pumps combined is +130 Pg C, i.e. a 24% share of the net CO2 uptake (541 Pg C), which is larger than the priming effect of the solubility pump (+93 Pg C). We further quantify the impact of marine carbon pumps on marine carbon-climate feedbacks. In total, marine carbon-climate feedbacks reduce the marine carbon sink, compared with the gross Canth uptake of an ocean without climate change. Biological carbon pumps (soft tissue + CaCO3 counter pump), however, dampen the magnitude of carbon-climate feedbacks by 30 Pg C over the simulation period, while the solubility pump enhances it by about 20 Pg C. Overall, an ocean without marine carbon pumps would take up considerably less anthropogenic CO2 (- 222 Pg C) until year 2100 under a high emission scenario. On top of this, such an ocean would show stronger carbon-climate feedback, i.e. being more sensitive to climate change, it would respond with stronger CO2-release to warming and circulation changes.
Decoding Workplace Stress: A Comprehensive Analysis of Demographic Correlations, Occupational Dynamics, and Intervention Strategies
Authors: Alfahed Ousama Bakri , Arif Samir Ibrahim , El-Malky  , Binsaeed Mohammad Abdulrahman , Alhawti Waad majed , Yustianingsih Miya , Amer Yasser Sami 
Published: February 2025

Abstract

Background
Workplace stress strongly affects employee well-being and organizational performance in high-stakes fields such as health care. The implementation of successful therapies depends on an awareness of the elements causing stress, including demographic elements and occupational traits. Focusing on age, job position, and employment length, this study examined the frequency and factors of workplace stress among King Saud University Medical Centre staff members.
Objectives
The main goal of this study was to assess the distribution of occupational stress levels among employees and identify important demographic and occupational correlates of stress. This research aimed to offer practical information to enhance occupational health campaigns and create a conducive workplace.
Methods
A total of 450 King Saud University Medical Centre staff members completed a cross-sectional survey. Using a standard scoring system, the survey evaluated stress levels and compiled demographic information such as age, job title, and employment duration. Low (0–3 points), moderate (4–9 points), and high (10–20 points) stress levels were assigned categories. Descriptive statistics were used to compile the information, and chi-square tests were used to assess the relationships between demographic factors and stress levels.
Results
While 41.3% of the individuals reported moderate stress, 7.3% experienced high stress, and most reported low stress—51.3%. Age and stress level were strongly correlated (p = 0.004; employees between the ages of 26 and 40 were most sensitive to both moderate and severe stress). With respect to stress (p = 0.001), employment duration also exhibited a notable correlation, indicating that younger workers were more stressed than were their more experienced colleagues. While employment status did not indicate statistically significant stress variation (p = 0.179), nurses accounted for the largest group experiencing various stress levels.
Conclusion
The results draw attention to important stress patterns, especially for nurses, younger workers, and mid-career professionals. It is essential to address these pressures by means of customized interventions, such as mentoring programs, supportive supervision, and systemic organizational reforms. The King Saud University Medical Centre can improve employee well-being and service quality by means of a strong workforce, therefore creating a better and more efficient workplace. Future research should include more professional group representations to enhance knowledge and guide focused initiatives.
The effect of space, time and night-time light intensity on antenatal care coverage in Bangladesh
Authors: Baffour Bernard , Das Sumonkanti , Talukder Ashis , Richardson Alice 
Published: February 2025

Abstract

This paper presents a small area estimation approach to assess trends in antenatal care (ANC) coverage among reproductive-age women in Bangladesh at various disaggregated levels. A multinomial multilevel time-series model is developed using district (admin-2) level ANC coverage data, categorizing women into three groups: (i) those with no ANC visits (ANC0), (ii) those with 1-3 visits (ANC123), and (iii) those with four or more visits (ANC4 +). The model accounts for the distinct behavioral profiles of each group in relation to factors influencing maternal health coverage, using remote-sensed night-time light intensity data to provide improved estimates. Our proposed small area model-based estimators incorporate significant social, economic, and geographical disparities, allowing us to identify regions exhibiting progress, stagnation, or decline. The model-based estimates demonstrate improved precision over direct estimates and provide valuable insights for designing targeted interventions to maximize impact. Additionally, a 1 spatio-temporal extension of the multinomial multilevel logistic model has yielded further refined estimates, helping to uncover disparities in the trends of maternal health care access. In Bangladesh, as in many developing countries, the health system operates under a decentralized structure, making district-level statistics crucial for localized planning and decision-making to ensure health equity.
Methods of extraction, separation and identification of cyclic peptides from flaxseed (Linum usitatissimum L.): A review
Authors: Sobolev R. V. , Sokolov I. E. , Petrov N. A. , Sarkisyan V. А. , Kochetkova A. A. 
Published: February 2025

Oilseed flax (Linum usitatissimum L.) is a valuable crop characterized by a high content of fats, dietary fiber, protein and various biologically active substances, in particular cyclopeptides. Cyclic peptides are a group of cyclic hydrophobic peptides consisting of eight to ten amino acids with a molecular weight in the range of 950–2300 Da. Flax oil and seeds contain from 0.1 to 0.3% cyclopeptides, which can exhibit antioxidant, anti-inflammatory, immunosuppressive, antihypertensive and antitumor activity. The aim of this review was to systematize and summarize the available literature data on methods of extraction, separation and identification of cyclopeptides from flaxseed oil. It was found that the main methods for obtaining cyclopeptides are solid-liquid, liquid-liquid or solid-phase extraction. Commonly used solvents include methanol, hexane, ethyl acetate, dichloromethane, acetonitrile and deionized water. Preparative flash chromatography on silica gel or polymer adsorbents is used to purify and concentrate cyclopeptides, and high-performance liquid chromatography (HPLC) is used to obtain individual standards. The most commonly used stationary phases are non-polar modified sorbents — octadecyl (C18) and phenylhexyl functional groups. Identification is carried out using instrumental methods of analysis: IR spectroscopy, NMR, HPLC with a diode array detector (HPLC-PDA/DAD), high-resolution tandem mass spectrometry with electrospray ionization (ESI-HR-MS/MS). For the qualitative and quantitative determination of cyclopeptides, the HPLC with a diode array detector at a wavelength of 214 nm is sufficient. In turn, mass spectral methods, including tandem mass spectrometry, make it possible to confirm the qualitative composition and establish the amino acid sequence of cyclic peptides.