bluuebunny/crossref_metadata_2025_split huggingface dataset:
Analysing Distribution Approaches for Efficient Urban Logistics
Authors: Salehi Salar , Ippolito Nicola , Gentile Guido , Miristice Lory Michelle Bresciani 
Published: November 2023

Abstract
Urban logistics plays a crucial role in modern society by covering all the flows of goods and services in the transportation world. This study aims to compare different delivery distribution scenarios using the aggregation of stops by grouping entities, for instance, the postal code approach (PCA) and the volume-based approach (VBA), to indicate the most effective one in simplifying urban logistic operations. These two scenarios illustrate two aggregation criteria: geographical, which groups stops with those closest ones, and non-geographical, which tends to cluster stops with similar stops. Used stops came from a real-world dataset acquired from urban logistics operator in the East of Rome. This study uses an optimizing algorithm called Traveling Salesman Problem (TSP) and Google Matrix API to calculate the shortest path and travel time. A comparison of those two approaches has been made to illustrate the similarities and differences in CO2 emissions, travel length, travel time, and unloading time. Although PCA is influenced by demand level, results show that PCA leads to a shorter travel time, shorter travel length, and less emissions produced. Furthermore, VBA is a more heterogenous distribution while PCA contains more homogeneity. The outcome could have the potential for companies and researchers interested in urban logistics due to the proposal of a new way of making distributions, real-world data usage, and comparing different scenarios.
Robo-advisory as a driving force of the financial market in the light of digitalization?
Authors: Mrkývka Petr , Šiková Zuzana 
Published: November 2023

AbstractThis article deals with the phenomenon of Robo-advisory used in the provision of investment services. It is appropriate to consider the use of this tool from a regulatory perspective, particularly given the widespread use of digital tools in financial markets and the growing interest of users in the digitization of services. Given the rapid development of digitalization, legislation may not always take into account the use of digital tools. Legislative changes may be delayed. The main objective of this article is to analyze Robo-advisory specifically from the perspective of EU regulation. The aim is to confirm or disprove the hypothesis. Based on the analysis, we are then able to look at using Robo-advisory from different perspectives, both practical and regulatory. The analysis also highlights the similarities and differences between traditional and alternative investment service provision.
State Regulation of Guest Houses Activities Considering Sustainable Development Requirements
Authors: Танина А.В. 
Published: November 2023

В статье рассматриваются особенности государственного регулирования гостевых домов с учетом требований устойчивого развития. На основании рассмотрения анализа действующего законодательства делается вывод о необходимости совершенствования классификации гостевых домов с учетом экологических, социальных и экономико-управленческих аспектов деятельности. Предлагается учитывать при разработке категорийных требований к классификации гостевых домов региональные особенности и вид туризма.
We look at the peculiar features of state regulation of guest houses, considering the requirements of sustainable development. On the basis of the analysis of the current legislation, the conclusion is made about the need to improve the classification of guest houses, considering environmental, social and economic-management aspects of their activity. We suggest consideringregional peculiarities and type of tourism when developing category requirements for guest houses classification.
Innovations of Institute of Terminating Citizenship of Russian Federation
Authors: Воронина О.В. 
Published: November 2023

В статье проанализирован институт прекращения гражданства Российской Федерации с учетом принятия Федерального закона от 28 апреля 2023 г. № 138-ФЗ «О гражданстве Российской Федерации», который вступает в силу 26 октября 2023 г. Сложность анализируемого института обусловливает отсутствие единой правовой и исследовательской позиции относительно вопроса определения терминов «прекращение гражданства», «лишение гражданства», «отмена решений по вопросам гражданства», «утрата гражданства». В результате исследования сформулированы предложения по совершенствованию правовых норм, составляющих институт прекращения гражданства РФ. В частности, автор предлагает на законодательном уровне закрепить определения понятий «прекращение гражданства» и «лишение гражданства» с целью их разграничения.
The article provides analysis of the institute of termination of Russian citizenship in view of the adoption of Federal Law of 28 April 2023 No. 138-FZ «On Russian Federation Citizenship» which comes into force on October 26, 2023. The complexity of the institution under analysis deals with the lack of unified legal and research position with regard to defining terms «termination of citizenship», «deprivation of citizenship», «revocation of citizenship decisions», «loss of citizenship». As a result of the research there have been formulated proposals for improving legal norms constituting the institution of termination of Russian citizenship. In particular the author suggests that definitions of terms «termination of citizenship» and «deprivation of citizenship» should be enshrined at legislative level in order to distinguish between the ones.
SAMPLES FOR COMPARATIVE RESEARCH IN FORENSICALLY MEANINGFUL SYSTEM OF INFORMATION
Authors: Иванова Е.С. 
Published: November 2023

В статье представлен анализ и предложено авторское определение криминалистически значимой информации, проведена оценка категории «образец для сравнительного исследования» как процессуального и криминалистического явления для конкретизации его места в системе криминалистически значимой информации. Результатом выполненной работы стало определение места образцов для сравнительного исследования в системе криминалистически значимой информации с визуализацией ее логических связей.
The article presents analysis and the author’s own definition of forensically significant information. It provides evaluation of the «sample for comparative research» category as a processual and forensic phenomenon to specify its place in the system of forensically meaningful information. The research resulted in defining the place of samples for comparative research in the system of forensically relevant information with the visualization of its logical relationships.
PENGARUH TELADAN KEPEMIMPINAN, SANKSI DAN PENGAWASAN TERHADAP DISIPLIN KERJA APARAT DESA KECAMATAN PLAMPANG KABUPATEN SUMBAWA
Authors: Aprillia Nanda , Serif Sarifudin , Sulaimiah Sulaimiah 
Published: November 2023

This study aims to determine the influence of exemplary leadership, sanctions and supervision on the work discipline of village officials in Plampang District, Sumbawa Regency. The method used is an associative method with a quantitative approach. The population of this study were all village officials with a total of 59 respondents. Data obtained by using a questionnaire. Data analysis technique used multiple linear regression test. The results showed that: (1) leadership examples, sanctions and warnings had a positive and significant effect on the work discipline of village officials, t-stat (3.990) ) > 2.004; (2) positive and significant responsive sanctions to the work discipline of village officials, t-stat (3.845) ) > 2.004; and (3) warnings have a positive and significant effect on the work discipline of village officials, t-stat (2.669) > 2.004.
Seasons and Human Health in the Hippocratic <em>Airs, Waters, and Places</em> and Hesiod’s <em>Works and Days</em>
Authors: Zatta Claudia 
Published: November 2023

This essay focuses on the doctor’s knowledge of seasonal patterns and their impact on human health in the Hippocratic Waters, Airs, and Places. Knowledge of the seasonal factor requires the doctor to master the general and the particular, to take the yearly period and scan it in two bi-seasonal periods with focus on summer and winter as the expected times for the outbreak of the diseases. Such looking-forward analytical operation is inscribed in the doctor’s capacity for pronoia. Due parallels are drawn between the doctor and the seer, on the one hand, and the Presocratic philosopher, on the other. Attention is also given to the early description of winter in Hesiod’s Works and Days: with its detrimental effects on human (and animal) bodies, it emerges as a poetic antecedent of the Hippocratic doctor’s knowledge.
Histological changes in the colon wall in adult patients with chronic slow-transit constipation
Authors: Leshchyshyn I. M. , Byk P. L. , Plodienko M. M. , Markulan L. Y. , Okhots’ka O. I. , Martyniuk N. S. , Dmytriieva K. M. 
Published: November 2023

The prevalence of chronic constipation in the population ranges from 3% to 27%. Women, senile people, and people of low socio‑economic status are in this risk group more often. Many histological studies of the intestinal wall were performed in order to find the causes of slow‑transit constipation [6, 4]. The different pathological changes, including myopathies, neuropathy, and pathology of the interstitial cells of Cajal, were established. The specific distribution of the types of histological changes in the colon wall in patients with slow‑transit constipation, as presented in the London classification, is currently unknown.
Objective — to determine the specific distribution of the types of histological changes in the colon wall in patients with slow‑transit constipation unresponsive to conservative treatment.
Materials and methods. A pathomorphological comparative case‑control study was performed. The main group included 105 patients who underwent colectomy as a treatment for chronic slow‑transit constipation in the period 2011—2023. The surgical intervention was indicated for patients with chronic slow‑transit constipation, resistance to conservative treatment, and a notable decline in quality of life. The comparison group included 27 deceased persons who did not experience constipation during their lifetime. The patient exclusion criteria were Hirschsprung’s disease, proctogenic constipation (dysfunction of the rectum and pelvic floor), medication‑associated constipation, as well as mental disorders. The histological and immunological examinations of samples were carried out in both groups, in the comparison group — appendix, ileum, cecum, colon and sigmoid colon.
Results. Four main morphological phenotypes of the colon wall structure elements in patients with chronic slow‑transit constipation were identified according to the research data: 1) histologically intact type, 2) myopathic type, 3) Cajal type, 4) neuropathic. A combination of different types of histological changes was also registered, but one of them usually dominated.
Conclusions. Four main types of histological changes in the intestinal wall were found in patients with chronic slow‑transit constipation resistant to conservative treatment: myopathic changes (56.2%), Cajal cell pathology (19%), neuropathic changes (19%), and a histologically intact variant (5.8%). The myopathic type is characterised by the heterogeneity of morphological manifestations, which can be referred to as dystrophic changes (dystrophic subtype 79.7%) and inflammatory changes (inflammatory subtype 20.3%), p=0.001.
The role and significance of mobile games in the process of psychological and psychophysiological development of young football players at the stage of initial training
Authors: Bairachnyi O.V. , Deineko I.V. 
Published: November 2023

Organized football increasingly goes against the capabilities and needs of the child. This trend is especially critical at the stage of initial preparation. In addition to the negative effects on the physical development of young football players, forcing training and ignoring their age characteristics has an extremely destructive effect on the mental development of children. The article analyzes the possibilities and advantages of pedagogical means of regulating motivational factors and the process of forming a number of psychological qualities and abilities of young football players aged 6 to 9 years. Suggested methods of personality formation of young football players. The formation of the sports character of young football players should consist of both team actions and individual characteristics.
Focusing on raising children begins in the environment that shapes them. The most important component of the formation of a young personality is the psychological aspect. Due to various movements with and without the ball, children can gain game experience. Adapting exercises to the child's needs is a basic condition for preventing traumatic effects and promoting its harmonious development, creating prerequisites for stimulating independent thinking, using the "try to find a solution" principle. The work summarizes data from special literary sources and domestic practical experience, as well as analyzes the key factors that determine the dynamics of training and physical and psychological development of young football players. The mechanisms of the influence of the use of pedagogical tools of a game nature on the process of formation of the motivational, cognitive and psycho- emotional sphere of a child of primary school age playing football are shown.
Content-functional model of formation of military-applied shooting skills from automatic small arms of future officers of the National Guard of Ukraine
Authors: Samsonov Yurii , Khatsaiuk Oleksandr , Litvinov Oleksii , Viaskov Volodymyr , Smahin Oleh , Shabatura Serhii 
Published: November 2023

The analysis of the combat experience of the units of the National Guard of Ukraine requires changes to the professional training programs of representatives of various categories of institutions of the security and defense sector of Ukraine, in particular - the programs of the "combat training" block, which will in the future ensure their high-quality performance of assigned tasks in extreme service-combat conditions activity.
The article is devoted to the topical issues of the formation of military-applied shooting skills from automatic small arms of future officers in the system of professional education with an emphasis on the use of modern technical training tools. According to the results of the analysis of scientific-methodical, special and reference literature by the members of the research group, it was established that the actual issue of forming military applied skills (professional competences) in shooting with automatic small arms of future officers of the National Guard of Ukraine with an emphasis on the use of modern technical means of training in the system of professional education - an insufficient number of scientific and methodical works are devoted, which, taking into account the realities of today, emphasizes the timeliness and relevance, as well as the practical component of the chosen direction of scientific research.
In the process of research and analytical work, the following research methods were used (at the empirical level):
abstraction, analysis and synthesis, induction and deduction, modeling, mathematical and statistical (correlation analysis, factor analysis, scaling), etc. In the process of research and analytical work, the experience of combat operations was also used, as well as the experience of organizing the system of fire and special physical training of future officers of institutions of the security and defense sector of Ukraine.
In the process of research and analytical work, a content-functional model of the formation of military-applied skills of shooting with automatic small arms of future officers of the National Guard of Ukraine was developed and tested using the "Katsumoto" video computer system of biomechanical analysis (VCSBA «Katsumoto»). For the first time, using VCSBA "Katsumoto", model characteristics of the general center of mass and individual biolinks of representatives of the studied category were obtained during shooting exercises with automatic small arms.
Book Reviews
Authors: Abele Célia , Prantil Sophie 
Published: November 2023

Alex Csiszar, The Scientific Journal: Authorship and the Politics of Knowledge in the Nineteenth Century, Chicago & London: University of Chicago Press, 2018.
Emmanuelle Reungoat, Enquête sur les opposants à l'Europe. À droite et à gauche, leur impact d'hier à aujourd'hui, Lormont, France: Le Bord de l'eau, 2019.
Molecular Basis of Tumorigenesis of Bladder Cancer and Emerging Concepts in Developing Therapeutic Targets
Authors: Abdeltwab Rana M. , Yacoub Elaria , Rashad Ahmed H. , Shohdy Kyrillus S. 
Published: November 2023

BACKGROUND: Advanced urothelial carcinoma (UC) is an aggressive disease whose mutagenic processes are yet to be elucidated. Targeted therapies are urgently needed, but the road from bench to bedside is slowly progressing. In this review, we discuss urothelial carcinoma etiology, along with the most recent advances in UC candidate targeted therapies. METHODOLOGY: A comprehensive database search was performed. We aimed to review the most recent updates on UC genomics and targeted therapies. Pre-clinical as well as clinical studies were included. RESULTS: Our review highlights the advances in understanding the molecular basis of urothelial tumorigenesis, including smoking, chemical parasitic carcinogens, inheritance, and APOBEC3 editing enzymes. We discussed how these factors contributed to the current mutational landscape of UC. Therapeutic options for UC are still very limited. However, several promising therapeutic approaches are in development to leverage our knowledge of molecular targets, such as targeting fibroblast growth factor receptors (FGFR), DNA damage repair pathways, and HER2. CONCLUSIONS: Blindly testing targeted therapies based on other cancer data is not sufficient. UC-specific biomarkers are needed to precisely use the appropriate drug for the appropriate population. More efforts to understand UC biology and evolution are urgently needed.
The immune response to systemically administered endotoxin in the murine intestinal microcirculation under pentobarbital versus isoflurane anesthesia
Authors: Neira Agonh Daniel , Scott Cassidy , Trivedi Purvi , Dickson Kayle , White Hannah , Zhou Juan , Lehmann Christian 
Published: November 2023

BACKGROUND: Pentobarbital and isoflurane are commonly used veterinary anesthetics. Due to the dangers of overdose by repeat-bolus regimen of pentobarbital, isoflurane has been recommended. However, literature suggests isoflurane-induced inhibition of cytokine and adhesion molecule release, impacting leukocyte adhesion. OBJECTIVE: This study aims to characterize the impacts of pentobarbital versus isoflurane on leukocyte interactions within the intestinal microcirculation with and without endotoxin challenge. METHODS: Female BALB/c mice were subjected to pentobarbital or isoflurane (N = 20) and challenged with endotoxin or saline by intraperitoneal injection. The mice were kept under anesthesia for 2 hours. Fluorochromes, rhodamine-6 G and fluorescein isothiocyanate, were injected intravenously. To visualize leukocyte adhesion within the intestinal microcirculation, laparotomy and intravital microscopy was performed. Leukocyte rolling and adhesion was quantified offline in a blinded fashion. RESULTS: Within collecting venules, leukocyte rolling and adhesion showed no significant differences between pentobarbital and isoflurane anesthesia under basal conditions. Endotoxin challenge caused a similar response in both anesthetic groups. Within postcapillary venules, no statistical differences between the two anesthetics were found for adhering leukocytes under basal conditions or following endotoxin challenge either. However, leukocyte rolling after LPS-challenge was significantly decreased in postcapillary venules during isoflurane anesthesia compared to pentobarbital anesthesia. CONCLUSIONS: Isoflurane anesthesia showed only minor differences in the immune response to endotoxin within the intestinal microcirculation compared to pentobarbital anesthesia. Due to the superior safety profile of volatile anesthetics, immunological studies may choose isoflurane over pentobarbital as the veterinary anesthetic of choice.
Can the CHOP-INTEND be used as An Outcome Measure in the First Months of Age? Implications for Clinical Trials and Real World Data
Authors: Cutrona Costanza , de Sanctis Roberto , Coratti Giorgia , Capasso Anna , Ricci Martina , Stanca Giulia , Carnicella Sara , Utlulig Meric , Bersani Giulia , lazzareschi Ilaria , Leoni Chiara , Buonsenso Danilo , Luciano Rita , Vento Giovanni , Finkel Richard S. , Pane Marika , Mercuri Eugenio 
Published: November 2023

Background: The CHOP-INTEND is an established outcome measure used to assess motor function in young and weak SMA patients previously validated in type I infants older than 3 months. Objective: The aim of our study was to assess the maturation of the CHOP-INTEND scores in a group of healthy infants, establishing which items of the scale can be reliably used in individuals younger than 3 months. Methods: This is a prospective observational study. The whole cohort was divided into 5 age groups. Each of the 16 CHOP-INTEND items was analyzed looking at the frequency distribution of the scores in each age subgroup. An item was considered developmentally appropriate when > 85% of the infants achieved a full score. Results: our study includes 61 assessments collected < 2 weeks, 25 at 2–4 weeks, 20 at 5–8 weeks, 25 at 9–12 weeks and 20 at 13–17 weeks. Eight of the 16 items were developmentally appropriate already in the first week and another by the end of the first month. The remaining 7 items had more variable responses in the first three months and full scores were consistently achieved only after the third month. Conclusions: Our findings suggest that the CHOP-INTEND can be used before the age of 3 months, but the results should be interpreted with caution, considering which items are developmentally appropriate at the time of testing. This will also help to establish whether the changes observed following early treatments are a sign of efficacy or at least partly reflect maturational aspects.