bluuebunny/crossref_metadata_2025_split huggingface dataset:
Study of correlations between yield and grain quality indicators of varieties and breeding lines of Triticum aestivum L.
Authors: Pravdziva I. V. , Vasylenko N. V. , Khoroshko N. M. 
Published: December 2023

Purpose. To determine the correlations between yield and grain quality indicators of varieties and breeding lines of winter bread wheat.
Methods. The study was conducted under the conditions of the V. M. Remeslo Myronivka Institute of Wheat NAAS of Ukraine (MIW) during 2019/20–2021/22. Ten new varieties and four breeding lines of winter bread wheat of Myronivka breeding were evaluated. Grain quality indicators were determined in the grain quality laboratory of MIW according to conventional techniques. Pearson’s correlation coefficients (r) were calculated to establish correlations.
Results. Correlations with different direction and strength were found between yield and quality indicators of winter bread wheat grain (–0.32 < r < 0.61). During the research years, reliable direct correlation coefficients were obtained between yield and the 1000 kernel weight indicator (r = 0.17–0.46). Also, a reliable linear dependence (r = 0.13–0.61) of yield with water absorption capacity of flour, test weight, grain vitreous, with protein and wet gluten content, but only under certain hydrothermal growing conditions. The varieties and breeding lines of winter bread wheat were identified which, during the years of research, showed stable direct correlations between yield and the indicators of 1000 kernel weight, grain vitreous, protein content, wet gluten content, sedimentation value, dough elasticity index, deformation energy, dough tenacity, water absorption capacity of flour.
Conclusion. The selected varieties and breeding lines of winter bread wheat can be used in the breeding process as sources for combining high yield with certain improved quality indicators in one genotype to create competitive varieties.
Nutritional Therapy Strategies Targeting Tumor Energy Metabolism
Authors: Chen Taojia , Yu Haining 
Published: December 2023

Abstract:
Cancer is the second leading cause of mortality worldwide. The heightened nutrient uptake, particularly glucose, and elevated glycolysis observed in rapidly proliferating tumor cells highlight the potential targeting of energy metabolism pathways for the treatment of cancer. Numerous studies and clinical trials have demonstrated the efficacy of nutritional therapy in mitigating the adverse effects of chemotherapy and radiotherapy, enhancing treatment outcomes, prolonging survival, and improving the overall quality of life of patients. This review article comprehensively examines nutritional therapy strategies that specifically address tumor energy metabolism. Moreover, it explores the intricate interplay between energy metabolism and the gut microbiota in the context of nutritional therapy. The findings aim to provide valuable insights for future clinical research endeavors in this field.
Tubulin-gene Mutation in Drug Resistance in Helminth Parasite: Docking
and Molecular Dynamics Simulation Study
Authors: Swargiary Ananta , Boro Harmonjit , Brahma Dulur 
Published: December 2023

Background:
Drug resistance is an important phenomenon in helminth parasites.
Microtubules are among the key chemotherapeutic targets, mutations of which lead to drug
resistance.

Objectives:
The present study investigated the role of F167Y, E198A, and F200Y mutations in β-
tubulin protein and their effect on albendazole binding.

Methods:
Brugia malayi β-tubulin protein models were generated using the SwissModel platform
by submitting amino acid sequences. Mutations were carried out at amino acid sequences by
changing F167Y, E198A, and F200Y. All the model proteins (one wild and three mutated) were
docked with the anthelmintic drug albendazole using AutoDock vina-1.1.5. Docking complexes
were further investigated for their binding stability by a Molecular Dynamic Simulation study using
Gromacs-2023.2. The binding free energies of protein-ligand complexes were analyzed using the
MM/PBSA package.

Results:
The docking study observed decreased ligand binding affinity in F167Y and E198A
mutant proteins compared to wild proteins. MD simulation revealed the overall structural stability
of the protein complexes during the simulation period. The simulation also observed more stable
binding of albendazole in the active pocket of mutant proteins compared to wild-type proteins. Like
ligand RMSD, wild-type protein also showed higher amino acid residual flexibility. The flexibility
indicates the less compactness of wild β-tubulin protein complexes compared to mutant proteinligand
complexes. Van der Waals and electrostatic interactions were found to be the major energy
in protein-ligand complexes. However, due to higher solvation energy, wild-type protein showed
more flexibility compared to others.

Conclusion:
The study, therefore, concludes that mutations at positions 167 and 198 of the β-
tubulin protein contribute to resistance to albendazole through weakened binding affinity. However,
the binding of albendazole binding to the proteins leads to structures becoming more stable and
compact.
Ethylcellulose- An Amazing Polymer For Anticancer Formulations
Authors: Mittal Vishnu , Kriplani Priyanka , Guarve Kumar 
Published: December 2023

Background:
A cellulose derivative known as ethyl cellulose has gained a lot of interest because of its special qualities and prospective uses in systems for the controlled administration of medications. This study concentrates on patents that examine the use of ethyl cellulose for anticancer preparations. Polymeric drug delivery methods are gaining significant research due to their potential to enhance therapeutic effectiveness, improve bioavailability, and
reduce toxicity

Objective:
The primary objective of incorporating ethyl cellulose into anticancer preparations is
to develop safe, effective, and targeted therapies for the treatment of cancer. This study aims to
provide a comprehensive overview of recent patents that specifically explore the use of ethyl
cellulose in the prevention and treatment of different cancers.

Methods:
The patent review methodology employed an extensive search across multiple patent
databases to identify relevant patents on the utilization of ethyl cellulose in anticancer preparations.

Results:
The formulations described in these patents demonstrated sustained and controlled drug
release profiles, which resulted in improved therapeutic efficacy while minimizing potential adverse effects. Our comprehensive review revealed multiple patents that utilized ethyl cellulose as
a polymer in the creation of anticancer preparations. The studies conducted in these patents
showcased enhanced drug release kinetics, improved cellular uptake, and increased anticancer
activity compared to conventional formulations.

Conclusion:
The analysis of these patents strongly indicates that ethyl cellulose exhibits substantial potential as a versatile polymer for anticancer preparations. The findings strongly suggest
that incorporating ethyl cellulose into drug delivery systems can significantly enhance the effectiveness of anticancer drugs, thus benefiting patients.
Derivative-Based Analysis of Institutional Quality, Resource Abundance, and Economic Growth Dynamics
Authors: Muhammad Abdulgaffar , Jeroh Edirin , Abasido Anthony Unyime , Isyaku Maryam , Adesugba Anthony Kolade 
Published: December 2023

This paper delves into the intricate nexus between institutional quality, natural resource abundance, and economic growth through derivative-based mathematical analysis. Utilizing a framework represented by G=Rα* Qβ, the study explores how institutional dynamics sculpt growth trajectories. The first derivative delineates economic growth’s sensitivity to institutional changes, while the second derivative unveils curvature in growth dynamics. The synthesis of findings illuminates resonance or hindrances in growth due to institutional shifts. Theoretical insights highlight the transformative role of robust institutions in mitigating the resource curse. Policy implications emphasize resource revenue diversification, institutional fortification, human capital investment, environmental sustainability, and long-term vision. Limitations acknowledge the model’s simplification and call for expanded dimensions and empirical validation. This derivative-based approach, while potent, prompts further refinement for a comprehensive understanding of economic complexities.
Meningkatkan kepercayaan diri di sekolah pada remaja panti asuhan melalui konseling kelompok perilaku
Authors: Puspasari Karisma Dewi 
Published: December 2023

Self-confidence is essential for adolescents to have at school. Self-confidence at school can optimize adolescents' self-functioning while at school, both in teaching and learning activities and when interacting with their friends and teachers. Some adolescents from orphanages are vulnerable to low self-confidence due to differences in background between themselves and other people in general. Behavioral group counseling was considered to be a solution to increase adolescents' self-confidence. This study aimed to examine the effectiveness of behavioral group counseling to increase self-confidence at school in orphanage adolescents. This quantitative one-group pretest-posttest study involves six male and female adolescent subjects living in orphanages. Behavioral group counseling consisted of 15 sessions by applying the principles of behavioral learning theory, such as modeling, roleplay, and reinforcement. The self-confidence scale refers to Lauster's self-confidence theory, which has a reliability value 0.708. Data analysis used paired sample t-test. The results obtained p = 0.00 (p < 0.01) show that behavioral group counseling is effective for increasing self-confidence at school in adolescent orphanage subjects.

Rasa percaya diri merupakan hal yang sangat penting untuk dimiliki remaja di sekolah. Rasa percaya diri di sekolah dapat mengoptimalkan fungsi diri remaja selama berada di sekolah, baik dalam kegiatan belajar mengajar maupun saat berinteraksi dengan teman dan gurunya. Beberapa remaja panti asuhan rentan mengalami rendahnya rasa percaya diri akibat perbedaan latar belakang antara dirinya dengan orang lain pada umumnya. Konseling kelompok perilaku dinilai dapat menjadi solusi untuk meningkatkan rasa percaya diri remaja. Penelitian ini bertujuan untuk menguji efektivitas konseling kelompok behavioral untuk meningkatkan rasa percaya diri di sekolah pada remaja panti asuhan. Penelitian kuantitatif one-group pretest-posttest ini melibatkan enam subjek remaja laki-laki dan perempuan yang tinggal di panti asuhan. Konseling kelompok perilaku terdiri dari 15 sesi dengan menerapkan prinsip-prinsip teori pembelajaran perilaku, seperti modeling, roleplay, dan penguatan. Skala kepercayaan diri mengacu pada teori kepercayaan diri Lauster yang mempunyai nilai reliabilitas 0,708. Analisis data menggunakan uji Paired Sample T-test. Hasil yang diperoleh p = 0,00 (p < 0,01) menunjukkan bahwa konseling kelompok behavioral efektif untuk meningkatkan rasa percaya diri di sekolah pada mata pelajaran remaja panti asuhan.
Prediction of POMA-G Score from Spatiotemporal Gait Parameters
Authors: KÖSESOY İrfan 
Published: December 2023

POMA test, is a type of test used to evaluate an individual's ability to perform functional movements and activities and is commonly used in the field of rehabilitation and physical therapy to assess an individual's mobility and identify areas for improvement. POMA evaluation is typically conducted by experts who are trained in using this tool to assess mobility and balance in individuals. However, it is possible that the POMA score may vary depending on the expert who conducts the evaluation because different experts may have different approaches to evaluation, and an individual expert's evaluation may also vary over time. These differences in the evaluation may lead to variations in the POMA score and may impact its reliability. Gait analysis, on the other hand, is objective in nature, providing a more reliable way of assessing the mobility of individuals.
This study aimed to predict the measurements obtained in the gait portion of the POMA test (POMA-G) based on objectively obtained spatiotemporal gait parameters. To do this, a dataset consisting of gait parameters from 44 older adults was used. The POMA-G scores were rated by two physiotherapists, one of whom was an expert and the other who was familiar with the test but less experienced. The study also included an analysis of the reliability of physiotherapists’ assessment and the proposed prediction models.
DAFTAR ISI
Authors: Syamsir Syamsir 
Published: December 2023

Tema Edisi: Pendidikan Karakter DAFTAR ISI Artikel: Desi Areva Kontribusi Kepemimpinan Transaksional Kepala Sekolah dan Motivasi Berprestasi Guru Terhadap Profesionalitas Guru SMA Padang Utara Halaman 1 – 10 Dessi Susanti Kontribusi Iklim Kerja dan Insentif Terhadap Kepuasan Kerja Guru SMK Swasta di Bukittinggi Halaman 11 – 25 Edi Saputra Peranan Metode Diskusi dalam Pembentukan Karakter Mahasiswa Melalui Mata Kuliah Pendidikan Kewarganegaraan (PKn) Halaman 26 – 40 Erianjoni Integrasi Nilai-Nilai Kearifan Lokal Minangkabau ke dalam Materi Ajar Sosiologi dalam Pembentukan Karakter Peserta Didik Halaman 41 – 53 Gurniwan Kamil P Pembentukan Karakter Melalui Pendidikan Sosiologi Halaman 54 – 66 Ofianto dan Wahidul Basri Model Penilaian Kemampuan Berpikir Historis (Historical Thinking) dengan Model RASCH Halaman 67 – 82 Resensi Buku: MEMPERTAUTKAN DUA HATI, DUA NEGARA BANGSA (Mestika Zed) Halaman 83 – 91
PENINGKATKAN MOTIVASI BELAJAR PPKn MELALUI MEDIA PEMBELAJARAN LCD PROJECTOR PADA SISWA KELAS VII.4 SMPN 1 LUHAK NAN DUO
Authors: Azibah Azibah 
Published: December 2023

ABSTRACT This action research aims to determine whether LCD Projector learning medium can improve students' learning motivation in Civics class of VII.4 SMP Negeri 1 Luhak Nan Duo. This study was conducted with a qualitative approach through Classroom Action Research. The study was conducted in two cycles. Data of teachers and students activities obtained from the observer by using observation sheets. The findings show that civics learning using LCD Projector medium can improve students' learning motivation in Civics class of VII.4 SMPN 1 Luhak Nan Duo. In addition, 25 of the 34 students who take daily tests have reached the minimum mastery criteria (KKM). Based on the results of this study, it is concluded that learning activities using LCD Projector medium can improve students' learning motivation in Civics class of VII.4 SMPN 1 Luhak Nan Duo.Key Words: Student learning motivation, LCD projector, learning medium, Citizenship Education
EDITORIAL
Authors: Syamsir Syamsir 
Published: December 2023

Jurnal TINGKAP Volume XII, No. 1 bulan April 2016 ini menyajikan 6 artikel, yang terdiri dari 6 artikel hasil penelitian, 1 artikel teoritis/konseptual, dan 1 Resensi buku. Tulisan-tulisan tersebut terangkum dalam satu tema: Peningkatan Kualitas Pendidikan dan meliputi berbagai topik, yaitu: Evaluasi Program Pendidikan Inklusi di SMK Negeri 6 Padang (Arlina); Peningkatan Prestasi Belajar Melalui Pemberian Belajar Tambahan Pada Siswa Kelas X Program Keahlian Jasa Boga di SMKN 6 Padang (Asnimiarti); Peningkatkan Motivasi Belajar PPKn Melalui Media Pembelajaran LCD Projector Pada Siswa Kelas VII.4 SMPN 1 Luhak Nan Duo (Azibah); Manajemen Konflik dalam Pendidikan Menurut Perspektif Islam (Indah Muliati); Peningkatkan Aktivitas dan Hasil Belajar Matematika Melalui Model Belajar Kooperatif Tipe Time Games Tournament (TGT) Pada Siswa Kelas XII Jasa Boga 3 SMKN 6 Padang (Sri Atini); Pengaruh Gaji dan Motivasi Terhadap Kinerja Guru Pada SMA Swasta Bagan Sinembah, Rokan Hilir, Riau (Wardani Purnama Sari); dan Capaian Tingkat Profesionalisme Guru Pada SMP dan MTs Kota Payakumbuh (Aryadie Adnan). Selain itu Jurnal edisi ini juga dilengkapi dengan satu resensi buku yang ditulis oleh Syamsir: Pendidikan Karakter ala Luqmanul Hakim.
KETERAMPILAN BERPIKIR KRITIS MAHASISWA/MAHASISWI YANG MENYERTAI EKSPEDISI PENDAKIAN GUNUNG DI MALAYSIA
Authors: Mustafa Munauwar , Ismail Mohd Azril , Poespowidjojo Donny Abdul Latief Abdul Latief 
Published: December 2023

This study was carried out to look at the effect of participation in well known adventure mountaineering expeditions in Peninsular Malaysia, namely Chamah-Ulu Sepat and Trans Titiwangsa expeditions on the score of participants’ critical thinking skill. The study population were public university students who participated in one of the aforementioned expeditions within the period of data collection which was during the long break during the second semester academic session and the first semester of academic session. This study utilizes an established instrument developed by Watson and Glaser which is potentially able to help achieve the study objective, taking into consideration the validity and reliability of the construct and its suitability with the respondents. The findings of the study reveal that there is a significant difference between the score of critical thinking skill of the participants before and after the adventure climb. However, mean scores between the two expeditions reveals that they do not differ significantly.Therefore, it can be concluded that students participation in mountaineering expeditions can be used as a training method to enhance their critical thinking skills. The study adds to another approach of increasing the level of critical thinking skill through adventure mountaineering expeditions in Peninsular Malaysia.Keywords: Critical Thinking Skills, Training and Development, Incidental Learning, Adventure Training
評《與機器一起思考》
Authors: 尹 潔 
Published: December 2023

LANGUAGE NOTE | Document text in Chinese; abstract also in English.
In this paper, I first reiterate the views of Lyreskog et al. and stress the importance of discussing ethical questions in the context of ABT—a topic that has clearly not received enough attention in China. Second, given the current state of Chinese applied ethics, I focus on what Lyreskog et al. refer to as a “seismic shift in how we conceptualize much of what we take to be core values in medicine and healthcare” (Lyreskog et. al 2023, 11–34) to explain how to realize the innovative progress of ABT ethics in contemporary China. I agree in principle that frameworks aiming to offer ethical guidance in ABT situations should use ontologies and taxonomies that allow for conceptual flexibility and redesign. These frameworks should also be subjected to philosophical critique and modified in light of scientific practice.
為什麼侵入性腦機介面技術是危險的
Authors: 翟 振明 
Published: December 2023

LANGUAGE NOTE | Document text in Chinese; abstract also in English.
我們反對侵入性腦機介面應用於人類，主要原因是，我們還幾乎不知道人的意識產生的機制，侵入性腦機介面技術有可能抹掉人的意識；除此之外，應用介面的人很容易被外人控制，失去自由。總之，它違反了以下三條“非對稱原則”：1. 從客體到主體這個方向，資訊越通暢越好，控制信號阻滯度越高越好。2. 從主體到客體這個方向，控制信號越暢通越好，資訊密封度越高越好。3. 以上兩條的鬆動調節，以最嚴苛的程式保證以各個主體為主導。作為人機介面的代替方案，我們開以採用作為“擴展心智＂的互聯網和電腦來實行。傳統上，道家哲學按其義理也為反對侵入性腦機介面技術提供了支援。
People oppose the application of invasive brain–computer interfaces to humans, mainly because they still know little about the mechanism by which human consciousness is generated and such technology could erase human consciousness. In addition, people using brain–computer interfaces can easily be controlled by outsiders and lose their freedom. In other words, brain–computer interfaces violate the following three asymmetry principles. (1) From the object to the subject, the smoother the information flow, the better, and the higher the degree of control signal blockage, the better. (2) From the subject to the object, the smoother the control signal flow, the better, and the higher the degree of information sealing, the better. (3) The relaxation of the above two principles should be carried out using the most stringent procedure to ensure that each subject takes the lead. As a substitute for brain–computer interfaces, we can use the Internet and computers as a kind of “extended mind.” The principles of traditional Taoist philosophy also support opposition to invasive brain–computer interfaces.
關於腦機介面技術風險的再思考——一個商榷
Authors: 劉 俊榮 
Published: December 2023

LANGUAGE NOTE | Document text in Chinese; abstract also in English.
Although intelligent robots can have rationality and thinking beyond those of ordinary people, they do not possess human dignity, nor can they become consistent with human beings in terms of social status, rights and dignity. Human dignity includes life dignity and personal dignity. Brain–computer interface technology may not only pose a serious external threat to the dignity of human life but also endanger the embodied existence of human beings, resulting in the separation of body and mind and violating people’s personal dignity.
比較技術倫理學視域下的腦機介面技術
Authors: 劉 佳寶 
Published: December 2023

LANGUAGE NOTE | Document text in Chinese; abstract also in English.
Zhai Zhenming compares brain–computer interface (BCI) technology with artificial intelligence technology and other mind extension technologies (such as ChatGPT), which I refer to as “comparative technology ethics.” I believe that it is meaningful to conduct research using comparison in the field of bioethics or technical ethics. I attempt to develop this type of comparative research and propose a comparison between risk-in-experiment technology and risk-of-effect technology. Although in some respects BCIs fall into the first category, the question of whether BCIs should be prohibited should be analyzed on a case-by-case basis.
科技發展的倫理省思：評《為什麼侵入性腦機介面技術是危險的》
Authors: 陳 旻 
Published: December 2023

LANGUAGE NOTE | Document text in Chinese; abstract also in English.
The emergence and application of brain–computer interface technology have raised many ethical concerns related to individual autonomy, privacy, and potential for abuse. I support technological progress, but I emphasize ethics first. I believe that the application of brain–computer interface technology should respect the inherent value and dignity of every life. Subject to caution, exploring the use of this technology to alleviate the suffering of terminally ill patients could be considered. The principles of non-maleficence and proportionality of benefits and risks should also be upheld when applying this technology. At the same time, it is necessary to formulate reasonable ethical standards for technology, establish ethics committees, and supervise the research, development, and application of this technology.
PENERAPAN TEKNIK BERCERITA FABEL DALAM MENINGKATKAN KEMAMPUAN BERBAHASA ANAK DI PAUD AQILA BANDAR LAMPUNG
Authors: Wahyutina Ambar , Tisnawati Nina , Firdausyi Annisa Nur 
Published: December 2023

Penelitian ini bertujuan untuk mengetahui penerapan Teknik bercerita fabel dalam meningkatkan kemampuan berbahasa anak di PAUD Aqila Bandar Lampung. Jenis penelitian yang dilakukan adalah penelitian kualitatif, data yang di gunakam adalah: wawancara, observasi, dan dokumentasi dengan teknik analisis yang digunakan reduksi data, penyajian data, menarik kesimpulan. Hasil penelitian ini 1). Penerapan teknik bercerita fabel dalam meningkatkan kemampuan berbahasa anak di PAUD Aqila Bandar Lampung sudah cukup baik perkembangan bahasa anak dengan menggunakan cerita fabel,pertama teknik yang digunakan antara lain pemilihan tema yang menarik, menggunakan APE sesuai dengan tema yang diceritakan menggunakan Intonasi yang berubah-rubah sesuai dengan tema perkembangan bahasa secara umum sudah berkembang dengan baik, namun secara khusus masih ada beberapa anak yang harus di bimbing dan di monitor dalam tahap perkembangan bahasanya, 2).Menerapkan bercerita fabel ada beberapa tahapan yang di lakukan tahap persiapan atau perencanaan, tahap pelaksanaan merupakan realisasi dari persiapan atau perencanaan, tahap evaluasi berhasilkah metode cerita fabel dengan melihat hasil capaian peserta didik.