bluuebunny/crossref_metadata_2025_split huggingface dataset:
Inhibitory Potentials of Kappaphycus Alvarezii on Bacteria Isolated from Clinical Samples
Authors: Deepa VH  , Sivakami R  , Suyambu Rajan 
Published: November 2023

Kappaphycus alvarezii is one of the high stress tolerant sea weed with good biopotentials. This was collected, processed, extracted and subjected to antibacterial activity against MDR UTI isolates. All the isolates were identified using standard biochemicals and other textual procedures along with 16S rRNA sequencing. Antibacterial activity was assessed by disc diffusion method and followed standard textual procedures to assess MIC, MBC, Percentage inhibition, IC50 and LC50. Six different test organisms were used for studying antibacterial activity. Antibacterial activity of all extracts on different extracts were varied from 7.2±0.6mm zone of inhibition. Concentration required to inhibits the growth of the UTI causing test organisms found to varied from 383.3±57.7µg/ml to 1033.0±76.3 µg/ml. extracts inhibited the growth of bacteria especially Staphylococcus aureus var haemolyticus was up to 98.2%. antibacterial substances like flavonoids and phenolic compounds could be responsible for this kind of activity.
Prognostic role of <i>PD-L1</i> and <i>P53</i> proteins in oropharyngeal squamous cell carcinoma depending on the status of the human papilloma virus
Authors: Polatova D.  Sh. , Gildieva М.  S. , Madaminov A.  Yu. , Savkin A. V. , Sklyarov D.  S. 
Published: November 2023

Background: At a time lots of cases of HPV associated oropharyngeal squamous cell carcinoma (HPV + OPSCC) are on the rise and excellent outcomes are seen when comparing HPV-OPSCC, identification of HPV status has become a powerful and widely used marker. Despite this, 20–25 % of HPV + OPSCC patients relapse within 3 years. The most significant barrier to identifying patients at high risk of relapse and death is the lack of clinically useful prognostic markers.Methods: The study included 62 patients treated with OPSCC T1–4N0–3M0 (7th edition, AJCC) in 2015–2020 in clinics located in two large cities of Uzbekistan (Tashkent and Samarkand). The study analyzed the prognostic value of PD-L1 and p53 proteins in OPSCC, taking into account HPV status. In addition, the relationship between PD-L1, p53 and HPV status was analyzed, as well as their impact on patient survival.Results: Positive HPV status with positive PD-L1 expression improves overall survival of patients compared to their negativity (p = 0.261). The mutant type of p53 protein has a negative correlation with HPV status, which reduces survival time (p < 0.001). Wild type p53 is detected in a small number of patients, but it shows a positive correlation with HPV status as a strong protective factor that reduces the risk of death (p = 0.01).Conclusion: Positive HPV status is not always a reliable predictor of risk stratification for patients with OPSCC, because additional indicators associated with the development of OPSCC need to be identified to reinforce the value of predictive predictors other than HPV status.
Pharmacoeconomic evaluation of the accelerated recovery and blood saving program in extended combined operations on the pelvic organs
Authors: Lyadov V. К. , Garipov М. R. , Moskalenko A. N. , Kornev D.  О. , Feoktistov D.  V. , Polushkin V.  G. , Bulanov А.  Yu. , Ayupov R.  Т. , Galkin V.  N. 
Published: November 2023

Background: The newly diagnosed pelvic cancer appears to be locally advanced in every third patient, which requires a comprehensive approach to treatment and often extensive combined surgical interventions. Long duration of operations, blood loss, complications of the tumor process during or after previous treatment often lead to the development of complications, slow rehabilitation and increasing cost of treatment. The use of fast track protocol (FTP) and blood-saving technologies can reduce the impact of these adverse factors.Aim: The evaluation of the pharmaco-economic efficiency of fast track protocol and blood-saving technologies in patients after extended combined operations for pelvic tumors.Materials and methods: The study included 111 patients with pelvic tumors who underwent an extensive combined surgery for rectal or gynecological tumors. Among them, 52 patients were underwent the same fast track protocol with a focus on the use of blood-saving technologies (2020–2021), the management of patients in the control group was more conservative (n = 59, 2018–2019). After analyzing the factors affecting the treatment outcomes, 2 groups of 16 patients comparable in basic clinical indications were formed by selection of pairs patients using quasi-randomization to assess the direct costs of treatment.Results: The cost of treatment in the FTS group and the control group was 157744 ± 32728,72 and 273429 ± 217931,5 (P < 0,05) rubles, respectively. The lower blood loss (206 ± 70 ml vs 430 ± 208, р = 0,3) allowed for a statistically significant difference in the frequency of transfusion of blood components (2 vs 12, p < 0,0009), despite the higher cost of supplies in the FTS group (132913 vs 57347 rubles). Also, the resuscitation bed-day (1,75 ± 1,3 vs 3,5 ± 2, р = 0,5) and the postoperative bed-day (16,8 ± 8; 8–32; vs 27 ± 18, р = 0,6) were lower in the FTS group.Conclusion: According to our data using the fast track protocol and blood-saving technologies in a group of patients with locally extensive pelvic organs tumors has helped to reduce the cost of treatment and improve the efficiency of the hospital.
LUMINESCENT DETERMINATION OF EUROPIUM AND CERIUM IN THE JOINT PRESENCE IN SOLUTIONS – MELTS OF EQUIMOLAR MIXTURES NaCl–KCl
Authors: Teslyuk O. I. , Chivireva N. A. , Zinchenko V. F. , Doga P. G. 
Published: November 2023

Europium and Cerium belong to lanthanides of variable valency and have similar chemical properties. Luminescent method was proposed for the analytical determination of Eu(III) and Ce(III) with the simultaneous presence in the sample of [EuF3–CeF3 (1:1)]–[NaCl–KCl] (2:8), which is a promising material for detecting UV-solar radiation.
Determination of Eu(III) was carried out by the method of sensitized 4f-4f luminescence in a complex with nalidixic acid at an emission wavelength of 613 nm, λex =351 nm. During complexation, a standard ratio of Stark components to Europium is observed in the luminescence spectra, in contrast to the spectrum of the sample solution without the reagent. This fact indicates that the formation of complexes not only increases the intensity of Eu(III) luminescence, but also reduces the effect of Cerium present in the solution.
To determine Ce(III), its own luminescence caused by 5d-4f electronic transitions was used at an emission wavelength of 351 nm, λex =263 nm. The presence of Europium ions in the solution does not affect the nature of the luminescence excitation spectra and Ce(III) luminescence spectra.
For the quantitative determination of these lanthanides, the additive method was used, which allows to level the mutual influence of ions, as well as the influence of Ce(IV) on the determination of Ce(III).
It was found that the content of Eu(III) in the melt is 2.44–2.53% weight, which is in good agreement with the data obtained earlier when studying the EuF3 – [NaCl–KCl](1:9) system. Compared to EuF3, the solubility of CeF3 ((0.028–0.032)% weight) is significantly lower than that predicted by previous thermodynamic calculations.
The obtained data allow us to conclude that the solubility of fluoride systems containing Eu in the NaCl–KCl melt is almost the same, and the presence of Ce(III) does not significantly affect the EuF3 dissolution process, and therefore does not affect the properties of the systems [EuF3 – CeF3] – [NaCl–KCl] as detectors of ultraviolet solar radiation.
ANALYSIS OF THE POSSIBILITY OF CHP FUNCTIONING IN THE ELECTRICITY MARKET UNDER THE CONDITIONS OF INTRODUCTION OF PRICE RESTRICTIONS ON THE MARKET
Authors: Dovhal Maxim , Zamulko Anatolii 
Published: November 2023

In the article, the issue of forming a strategy for ensuring competitive advantages of combined heat and power plants in the context of introducing price constraints in the electricity markets is considered, based on the analysis of functional capabilities and the economic component of the existing electricity market model. The factors influencing the formation of the cost of a unit of commodity production of a combined heat and power plant for participation in the electricity markets are also examined.
The work also discusses the issue of adapting thermal power plants to price constraints in electricity markets, which ensures competitiveness and stability of electricity production. The main aspects analyzed in the study include SWOT analysis of CHP plants, examination of regulatory mechanisms such as ancillary services for frequency and active power regulation, and modernization and environmental adaptation strategies.
Within the framework of the study, possibilities for enhancing the competitive advantages of CHP plants are considered, such as the introduction of the latest technologies, the development of the renewable energy market, and increasing capacity. At the same time, attention is paid to threats related to the decline in demand for electricity, changes in the fuel market, and regulatory constraints on harmful emissions.
CRITERIA AND CONDITIONS OF THE INTER-CIRCUIT THERMODYNAMIC INSTABILITY OF THE NPP’S MODERNIZED TURBINE SYSTEM
Authors: Skalozubov Vladimir , Kondratyuk Vadym , Filatov Volodymyr 
Published: November 2023

The original method of determining the criteria and conditions of inter-circuit thermodynamic instability in the modernized system "steam turbine - regeneration system with absorption heat pumps" is presented. This was developed through a thermodynamic analysis of the effect of independent fluctuating deviations from equilibrium in both the wet vapor flow at the absorption heat pump inlet and the measured pressure in the absorption heat pump/low pressure mixing heaters. Unlike known approaches to modeling thermodynamic processes, the thermodynamic model of the developed method takes into account the influence of fluctuating deviations from the equilibrium state of thermodynamic parameters, which determine the criteria and conditions of interloop thermodynamic instability. Based on the analysis of the received criteria and conditions, it was established that the main cause of inter-circuit thermodynamic instability in the modernized system "steam turbine unit — a regeneration system with absorption heat pumps" is determined by the incompleteness (inertia) of heat-mass exchange and hydrodynamic processes during fluctuating deviations from the equilibrium state of thermodynamic parameters. Prevention of the conditions for inter-loop thermodynamic instability in the modernized system "steam turbine unit — a regeneration system with absorption heat pumps" can be ensured by installing flow controllers in the wet steam supply circuits from the high-pressure cylinder of the turbine to the absorption heat pumps, and absorption heat pumps in mixing heaters low pressure to maintain a constant pressure in absorption heat pumps and low pressure mixing heaters. It is also necessary to consider that the modernization of the "steam turbine unit — a regeneration system with absorption heat pumps" system can affect the performance and conditions of inter-loop thermodynamic instability of "neighboring" systems. These issues determine the need for further analysis of the validity of the modernization of the "steam turbine unit — a regeneration system with absorption heat pumps" systems.
OBTAINING UNSATURATED HYDROCARBONS FROM COAL
Authors: Filimonenko Nina , Філімоненко Костянтин 
Published: November 2023

The article is devoted to the improvement of the technology of obtaining Liquid Motor Fuels from Coal. Unsaturated hydrocarbons are the most important chemical raw material products and are widely used for producing polymers, alcohols and some other organic substances. The paper considers the proposition of technological process of obtaining Synthetic Fuel from Coal with a positive yield effect of the final product with high quality. It is possible to organize the production of Liquid Fuel is made of Coal conversion. The method of Coal conversion into Liquid Motor Fuel is its gasification and hydrogenation but this is not the only way out. The paper proposes the possibility of creating the small plants for the production of synthetic fuels and components of organic synthesis, which can be used of the capacity of metallurgical factories and shops of machine-building enterprises that are vacated areas. In modern society the need is growing to use alternative liquid fuel technologies, for example, by indirect liquefaction of coal. This is especially important for Ukraine during and after hostilities. Ukraine does not have sufficient oil and gas reserves, but it has coal deposits in the coal basin in the west of the country.
An important aspect that is insisted on is the achievement of energy independence. Given the historical traditions and the existing structure of energy deposits in Ukraine, one of the ways to solve this strategic task should be the development of the coal industry. In addition, the environmental component of each of these types of security can be an integrator that integrates them into the national security system. This will help to find their optimal ratio in this system. Moreover, today there is no doubt that any aspect of national security, whether economic, technological or defense, loses its meaning in the event of unfitness of the environment for human life and activity. An influential factor in increasing production of coal for processing in the western part of Ukraine is the maximum extraction of coal reserves and at the same time protection of subsoil.
SYSTEMATIC INFORMATION BASE OF ENERGY-EFFICIENT APPLICATIONS FOR AVIATION PETROL
Authors: Boichenko Sergii , Shkilniuk Iryna , Yakovlieva Anna , Dokshyna Sofiia , Kuberskyi Ihor , Sibilieva Olena 
Published: November 2023

The additives in petrol was started to use in the first half of the twentieth century. In the late 1970s, a qualitative conceptual change in the development of this area of science and practice took place. Environmental pollution from harmful emissions led to the modification of petrol formulations and structural improvements of engines. The problem of improving the quality of gasoline and fuels for jet engines is usually solved in two ways: by developing high-quality new products and by efficient use of traditional ones.
The proposed work analyses the scientific literature on energy-efficient additives to aviation gasoline and, on this basis, creates a systematic information base, namely: classification of the range of additives to gasoline (by the following features: chemical, physical and biological stability enhancers; flash point modifiers; combustion modifiers; washing; dopes that promote efficient operation of fuels at low temperatures; friction modifiers; marking agents; anti-corrosion agents; safety enhancers; surface-active property modifiers) and the range of anti-detonation and environmental (anti-emission) additives in aviation petrols.
The following additives are manufactured and approved for use in Ukraine: poly-functional additives representing a complex mixture of manganese compounds and mixtures of paraffinic and naphthenic hydrocarbons (TU 30218597.001[in Ukrainian] "Poly-functional additives "Eco-Octane". Technical specifications"); iron-containing multifunctional additives "Standard"; there are also known developments of oxygenates based on methanol, ethanol and other alcohols, alcohol processing products, ethers and other oxygen-containing compounds.
The research is being carried out within the framework of the project "Development of a technology for the production of new environmentally friendly high-octane aviation gasoline from domestic raw materials" at the expense of the state budget in accordance with the Order of the Cabinet of Ministers of Ukraine of 12 August 2022 No. 713-r "Pro zatverdzhennia pereliku naukovo-tekhnichnykh (eksperymentalnykh) rozrobok v ramkakh vykonannia derzhavnoho zamovlennia na naivazhlyvishi naukovo-tekhnichni (eksperymentalni) rozrobky ta naukovo-tekhnichnu produktsiiu u 2022 rotsi" [in Ukrainian] (registration number 2020.01/0242).
ПРОБЛЕМИ ПОКРАЩЕННЯ ЕКОНОМІЧНОГО СТАНОВИЩА СЕЛЯН КИЇВСЬКОЇ ГУБЕРНІЇ В ПРАЦЯХ МІСЦЕВИХ КОМІТЕТІВ ОСОБЛИВОЇ НАРАДИ З ПОТРЕБ СІЛЬСЬКОГОСПОДАРСЬКОЇ ПРОМИСЛОВОСТІ (1902–1903 РР.)
Authors: Священко З. , Скрипник О. 
Published: November 2023

Автори статті на основі аналізу «Праць місцевих комітетів» зробили спробу з’ясувати ключові аспекти діяльності Київського губернського комітету Особливої наради з потреб сільськогосподарської промисловості в контексті поліпшення економічного становища місцевих селян. Обґрунтовується, що члени місцевих комітетів Київської губ. планували покращити економічне становище місцевих селян за допомогою модернізації кредитно-фінансової, освітньої, виробничої сфери та реформи місцевого самоврядування. Ключовими аспектами діяльності Київського комітету з потреб сільськогосподарської промисловості в контексті поліпшення економічного становища місцевих селян стало кредитування сільських виробників, підвищення їх освітнього рівня, розвиток дрібної кустарної промисловості, вирішення транспортних проблем та створення виборних місцевих органів самоврядування — земств.
Ключові слова: селянство, аграрне питання, Особлива нарада з потреб сільськогосподарської промисловості, місцеві комітети, Київська губернія.
МИХАЙЛО МИХАЙЛОВИЧ ДЯЧЕНКО: ЖИТТЄВИЙ І ТВОРЧИЙ ШЛЯХ
Authors: Щербань А. , Соляник А. 
Published: November 2023

М. М. Дяченко — український культурний діяч, художник, ілюстратор, педагог, бібліотекар, дослідник орнаментів та архітектури, що активно працював у 1908–1941 рр. Його життєвий шлях і творча спадщина донедавна були маловідомими. У статті вперше концептуально осмислено значну кількість збережених в українських архівах і бібліотеках рукописних та опублікованих документальних джерел, що характеризують його життєвий і творчий шлях. На основі зібраних матеріалів відтворено найповнішу нині біографію.
Ключові слова: українська біографістика, М. М. Дяченко, українська культура, музейна діяльність, мистецтво.
АНТИСЕМІТСЬКА ПРОПАГАНДА В ГАЗЕТІ «ВОЛИНЬ» ТА ЖУРНАЛІ «УКРАЇНСЬКИЙ ХЛІБОРОБ» РІВНЕНСЬКОГО ВИДАВНИЦТВА «ВОЛИНЬ»: ПОРІВНЯЛЬНИЙ АНАЛІЗ
Authors: Михальчук Р. 
Published: November 2023

У статті проаналізовано нацистську пропаганду в роки Другої світової війни на прикладі видавництва «Волинь» (м. Рівне): на основі порівняльного аналізу висвітлено спільні та відмінні риси антисемітських публікацій, надрукованих у газеті «Волинь» та журналі «Український Хлібороб». Звернено увагу на умови та мотивацію авторів до написання антисемітських публікацій.
Ключові слова: «Волинь»; «Український Хлібороб»; преса; антисемітизм; Голокост.
НУРСУЛТАН НАЗАРБАЄВ: ВІД РАДЯНСЬКОГО ФУНКЦІОНЕРА ДО АРХІТЕКТОРА НЕЗАЛЕЖНОСТІ КАЗАХСТАНУ
Authors: Латиш Ю. 
Published: November 2023

У статті розглянуто життєвий шлях першого Президента Республіки Казахстан Нурсултана Назарбаєва від народження до проголошення незалежності цієї держави. Метою статті є дослідити формування Н. Назарбаєва як політика й державного діяча, проаналізувати сторінки його трудової біографії, еволюцію поглядів на економічні, екологічні проблеми республіки, політику перебудови, стосунки з союзним центром, його роль у розпаді СРСР та появі незалежного Казахстану. Особливу увагу акцентовано на періоді його навчання в Україні та ставленні до України.
Було встановлено, що Н. Назарбаєв рішуче відстоював економічний суверенітет Казахстану, право республіки розпоряджатися своїми природними ресурсами, вести міжнародну економічну діяльність. При здійсненні реформ керувався принципом: «спочатку економіка, потім політика». Тому Президент Казахстану проводив досить обережну політику, не виступав за незалежність, підтримував ідею нового союзного договору, який на практиці зосереджував всю владу в руках республіканських еліт. Під час ключових моментів останнього періоду існування СРСР Н. Назарбаєв уникав безпосередньої участі в подіях: відмовився від пропозицій обійняти посади прем’єр-міністра, віце-президента СРСР, заступника генерального секретаря ЦК КПРС, не висловлював підтримки, але й не засуджував серпневий путч 1991 р., ухилився від підписання Біловезьких угод про припинення існування СРСР, натомість використовував послаблення центру після путчу для наповнення реальним змістом суверенітету Казахстану.
Наприкінці 1980-х — на початку 1990-х рр. політичні погляди лідера Казахстану стрімко еволюціонували: від підтримки перебудови як оновлення «радянського соціалізму» до ринкової економіки під жорстким державним контролем (за зразком «азійських тигрів»), від захисту «оновленої федерації» економічно суверенних республік до цілковитої незалежності. У грудні 1991 р. Н. Назарбаєв взяв на себе місію модератора цивілізованого розлучення колишніх радянських республік. Його політичний феномен базується на величезному життєвому досвіді, глибокому знанні економіки й промисловості країни, обережному ставленні до національного питання, тонкій інтуїції, здатності ухвалювати стратегічні рішення.
Ключові слова: Казахстан, біографія, реформи, модернізація, суверенітет, незалежність, президент.
The Best Scenario of Cyber Attack Selecting on the Information and Communication System Based on the Logical and Probabilistic Method
Authors: Alekseichuk Lesia , Novikov Oleksii , Rodionov Andrii , Yakobchuk Dmytro 
Published: November 2023

Abstract
The task of analyzing and selecting the best scenario of a cyberattack on information and communication system is considered as a component of the task of analyzing systems security. A method and corresponding algorithm for finding the best scenario of an attack on information and communication system using a logical and probabilistic model is proposed. The model describes the development of adverse events that arise in the information and communication system from the implementation of possible attacks on the security system from cyberspace. Analysis of cyber attack scenarios allows predicting the development of possible adverse cyber security events from the implementation of multiple threats to the system. The developed method and corresponding algorithm for analyzing attack scenarios can be used to analyze the security of information and communication systems, as well as in automation systems for designing information security systems or designing attacks on such systems.