bluuebunny/crossref_metadata_2025_split huggingface dataset:
Measuring Implementation Outcomes Change Over Time Using an Adapted Checklist for Assessing Readiness to Implement (CARI)
Authors: Bourdeau Beth , Guzé Mary A. , Rebchook Greg M. , Shade Starley B. , Psihopaidas Demetrios , Chavis Nicole S. , Myers Janet J. 
Published: February 2025

Abstract
In 2017, the Health Resources and Services Administration’s HIV/AIDS Bureau funded an Evaluation Center (EC) to assess the rapid implementation of 11 evidence-informed interventions at 25 HIV care and treatment providers across the U.S. The EC conducted an implementation science-based evaluation, including longitudinal assessment of implementation outcomes as defined by Implementation Outcome Framework (IOF) of the Conceptual Model for Implementation Research. The EC adapted a measure originally designed for implementation readiness to capture seven implementation outcomes and administered the measure to site leadership every six months, from intervention launch through the end of the initiative. The adapted measure demonstrated adequate internal consistency within and across time periods. Individual outcomes changed over the course of implementation, with the greatest period of growth during the first six months. Longitudinal relationships between outcomes posited to be most relevant at early, mid- or late-implementation were not evident in these analyses; rather, relationships between the outcomes were significant within time periods. Finally, there were differences in the trajectory of outcomes based on characteristics of the site’s larger context. The use of this adapted measure across multiple implementation settings, assessing multiple interventions, is an important step forward in the comparability of implementation outcomes more broadly.
Socio-ecological Determinants of Detectable Viremia among Pregnant People Living with HIV in South Brazil: The Role of Stimulant Use Disorder and Homelessness
Authors: Hernandez Christopher Justin , Echegaray Fernando , Sundar Kavya , Yang Lanbo Z. , Cambou Mary Catherine , Segura Eddy R. , de Melo Marineide Gonçalves , Santos Breno Riegel , Varella Ivana Rosângela dos Santos , Nielsen-Saines Karin 
Published: February 2025

Abstract
Pregnant patients living with HIV are a priority group for the recruitment into the HIV healthcare cascade to prevent adverse maternal and neonatal health outcomes. Understanding the structural, interpersonal, and individual factors that are associated with detectable HIV viremia is of importance to guide outreach and intervention priorities. This was a retrospective cohort study of pregnant patients living with HIV who delivered from January 1, 2017, to December 31, 2023, at a tertiary-level hospital and referral institution for HIV care in Porto Alegre, Brazil. The socio-ecological model was used to guide hypothesis testing regarding associations with detectable viremia. In total, 549 patients were included, of whom 110 (20%) were found to have detectable viremia. Significant differences between detectable and undetectable viremia included prenatal care, homelessness, having a sero-different partner, and stimulant use. Multivariable associations included prenatal care (adjusted Risk Ratio [aRR] = 0.20, 95% Confidence Interval [95% CI] = 0.15–0.26), homelessness (aRR = 4.02, 95% CI = 2.74–0.26), stimulant use disorder (aRR = 3.30, 95% CI = 2.23–4.87), crack use (aRR = 2.82, 95% CI = 1.85–4.29), and cocaine use (aRR = 1.89, 95% CI = 1.17–3.06). Intervention research should focus on housing and mental health services, and how to mitigate their impact on HIV healthcare. Intervention research is greatly needed as current tools may not be sufficient to tackle the issue of stimulant use disorder and its effects on ART adherence.
Compartmentalization and the Role of Polyphony in Moral Dialogue
Authors: Turunen Taija , Lundgren-Henriksson Eva-Lena 
Published: February 2025

Abstract
Existing research on identity compartmentalization highlights concerns about moral (ir)responsibility arising from the incomplete integration of multiple role identities necessary for exercising full moral agency. Our study examines the (non)recognition of otherness by managers in morally ambiguous situations during industry-level changes. We adopt a dialogue-based approach, inspired by Bakhtin, and Ricoeur, to analyze compartmentalization from the perspective of polyphonic dialogue. Through an analysis of 61 interviews across four distinct change contexts, we identify five dialogue dynamics that either hinder or facilitate the recognition of alternative moral perspectives, shaping the formation of moral polyphony. We contribute to current understandings of compartmentalization by emphasizing its dialogical and fluid nature, the generative potential of division, and the role of conflicting moral convictions in change situations, as an ideal context for fostering moral polyphony.
The Relationships Between Adolescent Anxiety Sensitivity, Parent Emotional Availability, and Gender in the Context of Adolescent Anxiety
Authors: Kramer Lauren , Francis Sarah 
Published: February 2025

Abstract
Anxiety disorders often onset in adolescence and continue into adulthood. Multiple factors contribute to anxiety disorder development, such as parent emotional availability (EA) and adolescent anxiety sensitivity (AS). Previous research determined attachment is a similar construct to EA, and attachment is related to anxiety disorders. Moreover, EA is a more specific construct than attachment that can be targeted in therapy. It has been determined that adolescent attachment to parental figures contributes to anxiety, with AS mediating this relationship. The present research sought to determine if AS is one mechanism underlying the relationship between parent EA and adolescent anxiety, while exploring the moderating roles of parent and adolescent gender. In a Midwestern sample (13–19 years old), this study examined adolescent AS as a mediator of the relationship between perceived parent EA and adolescent anxiety, and gender as a potential moderator. Self-report data were collected from adolescents via Qualtrics. The findings supported the mechanism of adolescent AS as a mediator between perceived parent EA and adolescent anxiety. As AS emerges during adolescence, it is a pertinent treatment target for youth anxiety. Furthermore, this study underscores the significance of parent and adolescent gender and parental EA as treatment targets for adolescent anxiety. While targeting adolescent AS and enhancing parental EA can be beneficial for both male and female adolescents, focusing on parental EA may offer greater benefits for male adolescents. In sum, these findings can increase the efficacy of current parenting programs and further increase treatment outcomes for youth and families.
Microclimate temperature effects propagate across scales in forest ecosystems
Authors: Braziunas Kristin H. , Rammer Werner , De Frenne Pieter , Díaz-Calafat Joan , Hedwall Per-Ola , Senf Cornelius , Thom Dominik , Zellweger Florian , Seidl Rupert 
Published: February 2025

Abstract

Context
Forest canopies shape subcanopy environments, affecting biodiversity and ecosystem processes. Empirical forest microclimate studies are often restricted to local scales and short-term effects, but forest dynamics unfold at landscape scales and over long time periods.

Objectives
We developed the first explicit and dynamic implementation of microclimate temperature buffering in a forest landscape model and investigated effects on simulated forest dynamics and outcomes.

Methods
We adapted the individual-based forest landscape and disturbance model iLand to use microclimate temperature for three processes [decomposition, bark beetle (Ips typographus L.) development, and tree seedling establishment]. We simulated forest dynamics with or without microclimate temperature buffering in a temperate European mountain landscape under historical climate and disturbance conditions.

Results
Temperature buffering effects propagated from local to landscape scales. After 1,000 simulation years, average total carbon and cumulative net ecosystem productivity were 2% and 21% higher, respectively, and tree species composition differed in simulations including versus excluding microclimate buffering. When microclimate buffering was included, Norway spruce (Picea abies (L.) Karst.) increased by 9% and European beech (Fagus sylvatica L.) decreased by 12% in mean basal area share. Some effects were amplified across scales, such as a mean 16% decrease in local-scale bark beetle development rates resulting in a mean 45% decrease in landscape-scale bark beetle-caused mortality.

Conclusions
Microclimate effects on forests scaled nonlinearly from stand to landscape and days to millennia, underlining the utility of complex simulation models for dynamic upscaling in space and time. Microclimate temperature buffering can alter forest dynamics at landscape scales.
Lorentzian bordisms in algebraic quantum field theory
Authors: Bunk Severin , MacManus James , Schenkel Alexander 
Published: February 2025

Abstract
It is shown that every algebraic quantum field theory has an underlying functorial field theory which is defined on a suitable globally hyperbolic Lorentzian bordism pseudo-category. This means that globally hyperbolic Lorentzian bordisms between Cauchy surfaces arise naturally in the context of algebraic quantum field theory. The underlying functorial field theory encodes the time evolution of the original theory, but not its spatially local structure. As an illustrative application of these results, the algebraic and functorial descriptions of a free scalar quantum field are compared in detail.
Pharmaceuticals and personal care products in Canadian municipal wastewater and biosolids: occurrence, fate, and time trends 2010–2013 to 2022
Authors: Gewurtz Sarah B. , Auyeung Alexandra S. , Teslic Steven , Smyth Shirley Anne 
Published: February 2025

Abstract
The concentrations of 135 pharmaceuticals and personal care products (PPCPs) were determined in raw influent, final effluent, and treated biosolids at Canadian wastewater treatment plants (WWTPs) to evaluate the fate of PPCPs through liquid and solids trains of typical treatment types used in Canada and to assess changes in PPCP concentrations in wastewater matrices between 2010–2013 and 2022. PPCPs dominant in influent and effluent included the antidiabetic metformin, analgesics/anti-inflammatories (acetaminophen, ibuprofen, 2-hydroxy-ibuprofen), caffeine and its metabolite (1,7 − dimethylxanthine), theophylline (a bronchodilator and metabolite of caffeine), an insect repellent (N,N-diethyl-m-toluamide, DEET), and iopamidol (a contrast media for X-rays). PPCPs dominant in biosolids differed from those in influent/effluent and included antibiotics (fluoroquinolones and doxycycline), antidepressants (sertraline, citalopram, and amitriptyline), a preservative and antimicrobial agent (triclosan), an antihistamine (diphenhydramine), and an antifungal (clotrimazole). These elevated concentrations in influent/effluent and biosolids reflected their use in Canadian communities. PPCPs dominant in influent/effluent had relatively low hydrophobicity whereas those in biosolids tended to be more hydrophobic, or electrostatic forces governed their sorption. Higher removal of PPCPs was generally observed at WWTPs that used biological treatment compared to primary physical/chemical treatment. PPCP concentration changes in wastewater matrices between 2010–2013 and 2022 were influenced by risk management measures, warnings, the development of new pharmaceuticals, the COVID-19 pandemic, and other factors. These time trends reflected the limited information available on PPCP use in Canada. Continued periodic monitoring of PPCPs is recommended to fill data gaps on community use and release to the environment.
Synthesis of a Novel Supermagnetic Fe3O4 Nanoparticles and their Congo Red Dye Removal, Cytotoxic, Antioxidant, and Antimicrobial Activities
Authors: Gökdağ Semih , Caf Fatma , Doğaner Fulya , Kaya Bülent , Aykutoğlu Gürkan 
Published: February 2025

Abstract

Plantago
lanceolata is a traditional medicinal plant that has attracted significant interest from researchers due to the use of its physiologically active components, particularly polyphenolics (flavonoids, hydroxycinnamic acids), in various fields. The aim of this study is to synthesize iron oxide (PLE@FeNPs) nanoparticles using a green synthesis approach with Plantago lanceolata (P. lanceolata) leaf extracts, characterize them, evaluate their in vitro effects, and assess their use in the removal of Congo red (CR) from wastewater. We carried out the physicochemical characterization of the nanoparticles using UV–Vis, FT-IR, and XRD spectroscopies; TEM and SEM microscopy; and Zetasizer particle size analysis. While the distinct peaks in XRD confirm the crystalline structure, TEM has determined an average particle size (8 nm) for PLE@NPs with deformed spherical nanoparticles. The FT-IR spectra showed that bioactive compounds from P. lanceolata were involved in the participation of PLE@FeNPs. EDX confirmed the presence of iron in the designed PLE@FeNPs. The antibacterial, antioxidant, and anticancer analyses of the studied PLE@FeNPs revealed significant activities. We investigated the adsorption kinetics of CR on PLE@FeNPs, taking into account initial dye concentration, different pH levels, adsorbent dosages, and temperature. At optimal conditions (concentration, 50 ppm; dosage, 15 mg; pH, 8), the degradation of CR dye in sunlight was found to be 99%. The small size of PLE@NPs (8 nm) and the more negative zeta potential (− 12.2 mV) support this situation. The equilibrium data demonstrated a good fit to the Langmuir isotherm model, outperforming the Freundlich isotherm model. The results showed that the pseudo-second-order kinetic model accurately described the kinetic data. PLE@NPs exhibited significant antioxidant, antimicrobial, and anticancer activities. This situation suggests that the nanocomposition of PLE@NPs obtained through the green route may have improved efficiency due to various synergistic effects. Overall, these results pave the way for further applications in dye removal and biological applications of environmentally friendly PLE@FeNPs.

Graphical Abstract
Unraveling the Challenges of Difficult-to-Treat Spondyloarthritis: SPARTAN 2024 Annual Meeting Proceedings
Authors: Ribeiro Andre L , Proft Fabian 
Published: February 2025

Abstract

Purpose of Review
This review aims to explore the emerging concept of difficult-to-treat axial spondyloarthritis (D2T-axSpA), including its definitions, clinical challenges, and management strategies. The objective, as presented at the SPARTAN 2024 Annual Meeting, is to delineate the evolving framework for identifying and addressing D2T-axSpA, with a focus on inflammatory and non-inflammatory mechanisms of treatment failure and the implications for clinical practice.

Recent Findings
Studies have highlighted a prevalence of D2T-axSpA ranging from 19.5 to 28.3% in real-world cohorts, with associated risk factors including peripheral arthritis, comorbidities, and female gender. Recent advances include the Assessment of SpondyloArthritis International Society’s (ASAS) preliminary definition of “difficult-to-manage axSpA” (D2M-axSpA), which encompasses treatment-refractory cases and broader management challenges and `treatment refractory axSpA´ where objective evidence of ongoing inflammation is mandatory.

Summary
D2T-axSpA presents significant challenges due to persistent disease activity and the interplay of inflammatory and non-inflammatory drivers. The emerging definitions and research into personalized treatment strategies promise to refine clinical management. Future directions emphasize biomarker-driven precision medicine, novel therapeutic combinations, and holistic care models to improve outcomes in this complex patient population.
Making sense of response: How policies affect climate vulnerability
Authors: Malmström Alexandra , Käyhkö Janina , Räsänen Aleksi , Tuomimaa Julia , Juhola Sirkku 
Published: February 2025

Abstract
There is a gap in understanding how different policies affect climate vulnerability and risk development, yet increasingly response is added to the risk framework. We propose a conceptual framework that explains how response and other policies affect risk determinants and demonstrate the application of the framework using a synthesis of empirical literature on climate-related health risks and adaptation in cities. The analysis shows that most of the policies affecting vulnerability and exposure are outside climate interventions, i.e., current conceptualization of response. The inclusion of response and other policies in risk assessments has implications for adaptation research and practice.
Mackey functors for posets
Authors: Carrión Santiago Guille , Díaz Ramos Antonio 
Published: February 2025

Abstract
We define Mackey functors over posets mimicking the classical notion and introduce a weak version of them. Then we show that they are acyclic by analyzing cofibrant and pseudo-projective objects in the category of functors indexed in a filtered poset. As application, we study homotopy colimits over posets and we give a homology decomposition for the classifying space of the Bianchi group

$$\Gamma _1$$

Γ
1

.
Successful cure of multiple large, inoperable liver abscesses by antibiotic therapy
Authors: Niederreiter Sarah , Voelkerer Andreas , Datz Christian , Weiss Guenter 
Published: February 2025

Abstract

Purpose
Pyogenic liver abscesses are challenging due to their diverse etiology and the risk of severe complications. In many cases, surgical interventions are initiated. However, these are only applicable in selected scenarios. We report the case of a 63-year-old woman with multiple large liver abscesses of up to 6.7 cm spread across both liver lobes, which could not be managed surgically.

Methods & Results

Streptococcus intermedius was isolated in blood culture and PCR positivity for this pathogen was obtained in liver puncture specimen. Following a two-weeks course of intravenous therapy with cefuroxime, metronidazole and fosfomycin, the patients received a consecutive, combined oral antibiotic treatment with clindamycin and cephalexin for four months. This resulted in complete resolution of the abscesses, with no evidence of relapse at follow-up.

Conclusion
This case illustrates the complex therapeutic challenges in the management of multiple, large hepatic abscesses, highlighting the potential of antibiotic therapy to cure even inoperable patients.
A Narrative Approach to the Standard of Originality in EU Copyright Law: The Story of a Dress
Authors: Härkönen Heidi 
Published: February 2025

Abstract
“Originality” is the key requirement for copyright protection in the EU. Judgements of the Court of Justice of the European Union (CJEU) such as Painer and Brompton show that many aspects of the standard of originality are linked as much to the creative process as to the resulting subject matter. This is particularly true for the “free and creative choices” that authors must make when producing a copyright-protected work. However, we do not have much information about how the standard of originality is manifested in the practices of the creative sectors, especially when it comes to applied arts and industrial design, such as fashion design. Combining a narrative approach to research with the doctrinal study of law, this article examines a creative process by following the journey of the design of a garment – a dress – from idea to expression. The narrative is used as a case study to illustrate the kinds of choices made in the creative process that are significant for the dress to merit copyright protection. The significance of these copyright-relevant choices is contrasted with EU design law where they may lead to a different protection outcome. It is concluded that the more information we have about the creative process of an artistic work – regardless of category – the more accurately we can assess whether it qualifies for copyright protection. The article further argues that the process of fashion design is not inherently any less creative than other, less controversial, areas of copyright protection.
Efficient Optimization of Magnetic Properties of Fe–4.5Si Alloy in Laser Powder Bed Fusion (LPBF)
Authors: Song Byeong Uk , Choi Joon Phil , Lee Pil-Ho , Jung Min-Kyo , Shin Dongwoon , Ha Taeho , Lee Ikjin 
Published: February 2025

Abstract
Existing studies have successfully identified optimal process parameters to enhance relative density and mechanical properties. However, these optimizations often incur high experimental costs due to the need for repetitive experiments. This research introduces an efficient optimization framework using two design of experiment (DoE) methods and machine learning algorithms, aimed at optimizing the magnetic properties of Fe–4.5Si material. The framework consists of three steps: (1) identification of the process parameter region that ensures high relative density using cubic specimens, (2) development of surrogate models to predict magnetic properties, such as maximum relative permeability and core loss, using toroidal specimens, and (3) multi-objective optimization using the surrogate models and a multi-objective genetic algorithm (MOGA) to enhance magnetic properties. The results demonstrate that this method can efficiently optimize process parameters with a limited number of experiments. Furthermore, the versatility of this framework allows its application to other materials in the early stages of research, even without prior knowledge of specific materials.
Trajectories of Offending Among Asians in America: Examining US-Born/Non-US-Born Differences and the Effects of Social Control
Authors: Joo Sung Hwan , Koo Doyun , Watts Stephen J. 
Published: February 2025

Abstract
With the notable recent population growth of the Asian population in the US, the need for scholarly attention to offending patterns of this population has correspondingly increased. Utilizing waves of 1 to 4 of the National Longitudinal Study of Adolescent to Adult Health (Add Health) (n = 9412), the current study examines the offending trajectories among Asian populations in the US, with particular attention to the distinct experiences and offending patterns between US-born and non-US-born individuals. Employing group-based trajectory modeling (GBTM) and multivariate regression, the study reveals distinct patterns of offending between Asian and non-Asian populations, while highlighting significant variations in offending trajectories between US-born and non-US-born Asian populations. Results indicate that social control factors, such as social bonds and self-control, have varied influences across US-born and non-US-born Asian populations. Overall, the findings point to the importance of considering how distinct institutional adjustment processes and identity negotiations shape offending trajectories among Asian populations in the US. The discussion focuses on how the current study contributes to a deeper understanding of the complexities facing Asian populations in the US, suggesting future studies incorporate institutional adjustment processes to elucidate Asian offending trajectories further.