bluuebunny/crossref_metadata_2025_split huggingface dataset:
ANALGETIC ACTIVITY DETERMINATION OF PAPAYA LEAVES (Carica papaya L.) AND BASIL LEAVES (Ocimum sanctum L.) EXTRACTED USING NATURAL DEEP EUTECTIC SOLVENT
Authors: Amelia Renny , Falya Yuniarty , Tomi  , Daryuti  , Barkah Eka Umi 
Published: December 2023

Natural deep eutectic solvents (NaDES) are obtained from an adequate mixture of hydrogen bond acceptors (HBA) and donors (HBD), which can bond through the interaction of hydrogen bonds to form a eutectic with a low melting point. NADES has been implemented in several studies as an effective extraction method, but it is still not widely used. C. papaya leaves and O. sanctum leaves have been widely known to have various pharmacological activities. The aim of this study was to determine the best analgesic ability of the NADES extract of C. papaya and O. sanctum leaves. The extraction process used was Microwave-Assisted Extraction (MAE). The liquid extract was tested for antioxidant activity and analgesic activity using doses of 600 mg/kgBW, 800 mg/kgBW, and 1000 mg/kgBW. The results show that The IC50 values of the NADES extract of C. papaya and O. sanctum leaves were 920 ppm and 882 ppm, respectively. Both analgetic percentages are equivalent to the positive control starting from a concentration of 800 mg/kgBW, where the analgetic percentage of the NADES extract of papaya leaves and basil leaves is 59.80% and 54.57% respectively that included in weak category. It can be concluded that both NADES extracts of papaya and basil leaves have analgetic capabilities.
Keywords: Natural Deep Eutectic Solvent (NADES), Carica papaya, Ocimum sanctum, analgetic activity.
ИЗУЧЕНИЕ БИОЛОГИЧЕСКОЙ И ПИЩЕВОЙ ЦЕННОСТИ СУХОФРУКТОВ ИЗ СОРТОВ ВИНОГРАДА, ПРОИЗРАСТАЮЩЕГО НА ЮГЕ КАЗАХСТАНА
Authors: Кантуреева Гульжан , Мурзабаев Болат , Раисов Болат 
Published: December 2023

Сухофрукты, полученные из винограда, благодаря сочетанию высокой питательной ценности и приятного вкуса считаются полезным продуктом питания.Изучение биологической и пищевой ценности сушеного винограда из сортов, произрастающих на юге Казахстана, проводилось на базе НИЛ «Проблемы АПК и ЭР»ЮКУ им.M. Ауэзова. Экспериментальная сушка винограда проводилась на инфракрасной сушильной установке ШС-80 по экологической современной технологии без применения химических реагентов на этапе предварительной обработки.В данной работе определены технологические параметры сушки (изменение массы сырья, время и продуктивность сушки)для четырех сортов винограда. В образцах сушеного виноградасодержится достаточное количествосахарозы(3,38 и 5,17),чтохарактерно для сортов винограда из южной области. По общему содержанию полифенолов образцы темных сортов винограда (Кишмиш, Мерседес, Тайфи розовый) показали хорошие значения в пределах 220,5-309,1мг ГК/100 г.Тогда как в белом сорте винограда было обнаружено наименьшее количество 110,0ГК/100 г.Также в опытных образцах отмечено высокое содержание калия (от 34% до 39%), кальция (в среднем 2,66-3,53%) и фосфора (2,92-3,88). Потребители и заинтересованные стороны могут получить выгоду от производства и реализации предлагаемых сушеных продуктов, какрегиональные бренды Казахстана или продукция с географическим указанием (ГУ).
Assessment of treatment outcomes for HIV Positives transitioned from Tenofovir/Lamivudine/Efavirenz to Tenofovir/Lamivudine/Dolutegravir in a Nigerian Tertiary Hospital
Authors: Ojo Omobola Yetunde , Ahmed AbdulMumin , Adeniran Adeyinka , Onigbogi Olarenwaju Olusola , Onigbogi Modupe Olajumoke , Alausa Kamil Olanipekun 
Published: December 2023

Objective: Dolutegravir, an integrase inhibitor replaced nevirapine or efavirenz (both NRTIs) in a fixed dose combination with Tenofovir/Lamivudine, as the preferred first-line option for the prevention and treatment of HIV infection. This study aimed to assess the treatment outcomes of the new Tenofovir/Lamivudine/Dolutegravir (TLD) regimen at the Federal Medical Centre Abeokuta.
Methods: This retrospective study used data drawn from the treatment register of patients who transitioned from Tenofovir/Lamivudine/Efavirenz (TLE) to TLD. Data were analyzed using SPSS v23. Descriptive statistics were used to describe categorical and continuous variables. Statistically significant independent variables in univariate analyses were included in the multivariate model. The level of significance was set at p<0.05.
Results: The 358 cases reviewed showed a mean age of 44.29 ± 11.5 years. The majority (267; 74.6%) were females. Viral load suppression (≤1000 copies/ml) was achieved in 313 (87.4%) while on TLE but increased to 339 (94.7%) when transitioned to TLD. Also, 36.3% had a high CD4 count while on TLE, this increased to 67.3%. The mean CD4 counts (428.59±251.85) while using TLE increased exponentially when transitioned to TLD (634.89±244.72) (t-31.601; p-value- 0.001). Before the transition, 90.5% of respondents were at WHO stage 1 compared to 92.5% after the transition to TDF/3TC/DTG.
Conclusion: Treatment outcome was greatly improved in terms of virologic, immunologic and clinical parameters among patients who transitioned from TDF/3TC/EFV to TDF/3TC/DTG. The outcome of this work supports and encourages the use of TDF/3TC/DTG as the preferred first-line regimen in HIV treatment for the patient’s maximum clinical benefit.
Risk Analysis and Assessment Framework for Cyber Security in Management Systems
Authors: TARAKÇI Emin , GÖNÜL Anıl Mustafa 
Published: December 2023

Organizations are depending more and more on interconnected digital ecosystems, therefore strengthening cyber security measures is essential. This paper offers a thorough framework for risk assessment and management that fits into the larger category of cyber security-focused management systems. The framework that has been suggest-ed combines state-of-the-art techniques from the fields of risk management and cyber security to build a resilient system that can deal with modern cyber threats.
The framework begins with a methodical inventory of resources—such as data centers, vital infrastructure, and network elements—that are necessary for the operation of the corporate cyber environment. A comprehensive risk assessment is then carried out, taking into account the possibility and consequences of any cyber attacks to the assets that have been identified.
Predictive modeling and scenario analysis are integrated into the framework to enable a proactive approach to risk mitigation. Consistent with well-known management system standards like ISO 27001 and DDO, the framework emphasizes an iterative and cyclical process. Regular risk reviews, performance reviews, and strategy updates for risk management lead to continuous progress. The synchronization of cyber security measures with changing organ-izational structures and developing threats is ensured by this adaptive approach.
In addition to strengthening an organization's cyber resilience, putting the suggested framework into practice ad-vances the more general objective of developing a strong and effective cyber security management system. This methodology offers a scalable and sustainable way to protect digital assets from the ever-changing pool of cyberat-tacks by smoothly integrating risk analysis and management into current organizational procedures.
This study offers a methodical and comprehensive approach to risk analysis and management, which adds to the continuing conversation on cyber security. The framework that is provided here acts as a useful manual for com-panies that want to strengthen their cybersecurity while adhering to accepted management system standards.
A Cross-Sectional Survey of Work-Related Musculoskeletal Disorders in Physiotherapists Using Orebro Musculoskeletal Pain Questionnaire (OMPQ)
Authors: Rahane Rohit Balasaheb , Kulkarni Nupoor Sanjiv , Khot Aditi Pramod 
Published: December 2023

Background:
Physiotherapists in India are at a high risk of work-related musculoskeletal disorder (WRMSD). Faulty ergonomics and incorrect patient handling techniques are the common causes of WRMSDs. The disabilities caused due to musculoskeletal injuries are the frequent cause of absenteeism from work.

Aim and Method:
The aim of this cross-sectional survey is to investigate the occurrence of WRMSDs among physiotherapists in Maharashtra using Orebro Musculoskeletal Pain Questionnaire. Responses were obtained through Google forms and analyzed. Three hundred sixty physiotherapists who fulfilled the inclusion criteria were recruited for the study. All the participants responded to the questionnaire.

Result:
The prevalence of WRMSDs was found to be highest in age of 23-30 years (87.22%) and less in age of 41-50 years (2.22%). Most common affected area was neck (43.6%) and lower back (43.1%).

Conclusion:
This study highlights the high incidence of WRMSDs among physiotherapists in Maharashtra.
Women Police Personnel’s Work-Family Conflict and Burnout from Individual’s Experience: The Moderating Effect of Stressful Working Environment
Authors: Bhuvaneswari D , Thirumoorthi P 
Published: December 2023

Aim:
This study investigates the relationship between Work-Family Conflict (WFC) and the individual’s experience of burnout by considering the moderating role of a stressful working environment.

Material and Methods:
The questionnaire holds “Work-Family Conflict” and consists of eight questions adopted from Carlson and Perrewé (1999). “Burnout” consists of three subconstructs, namely “Emotional exhaustion”, which carries four questions, “Depersonalization”, which has four questions, and “Personal accomplishment”, holding three questions adopted from Maslach Burnout Inventory (Maslach and Jackson, 1981). And finally, “Stressful work environment” consists of 10 questions adopted from Gershon (1999). The research instrument was distributed among women police working in Chennai and Kanchipuram regions. The data from 427 women police personnel were collected through a questionnaire using a simple random sampling method.

Statistical Analysis Used:
First, exploratory factor analysis was performed to test the standardization and tested for reliability using Cronbach’s alpha test. It found that all loadings are between 0.649 and 0.866, which is satisfactory. Second, for demographic questionnaire items, descriptive statistics were performed. Finally, to find the moderating effects of stressful work environment on the relationship between WFC and the individual’s experience of burnout, multiple hierarchical regression analysis was computed.

Results:
The results show that WFC positively affects burnout and it has been found that a stressful working environment moderates the relationship. It also supports that individuals experience a high level of burnout when the working environment and WFC are intense.

Conclusion:
The result supports that individuals experience high burnout when the working environment and WFC are intense. The study initiated an attempt to explain the mechanism through which a stressful working environment influences burnout levels.
Measuring the Economic Burden of Health Conditions among White-Collar Employees: A Cross-Sectional Study from Delhi-NCR
Authors: Yadav Monika , Viji B 
Published: December 2023

Background:
In the past few decades, there has been a significant increase in healthcare expenditure due to the prevalence of health issues across the globe. This is primarily seen among white-collar employees due to the sedentary nature of their jobs, which affects their current earnings (Purchasing Power) directly due to the reallocation of their real income towards healthcare expenditure (Economic Burden) and indirectly by impacting work productivity through sick leaves.

Aim:
To measure the economic burden of disease(s) among white-collar employees, and to study the same across different socio-demographic variables.

Methods:
A cross-sectional study has been conducted in the region of Delhi-NCR among 357 white-collar employees. A random sampling method was adopted using a structured questionnaire. The questionnaire collected information regarding the direct and indirect costs of health conditions with a recall period of one month. The cumulative score of these monthly costs was converted to annual data to estimate the economic burden of the health conditions among the employees over a year.

Results:
As compared to Communicable diseases (16.24%), Non-communicable diseases (27.17%) were more prevalent among the respondents. Compared to other diseases, the employees suffering from Heart diseases (INR 7,62,237.50), Spinal health issues (INR 1,73,625.00), and Diabetes (INR 1,64,535.71) incurred more economic burden. At a 5% significance level, no significant difference was observed in economic burden for Gender and BMI. However, the economic burden was significantly different across the categories of Age and Monthly income. A positive association can be observed in economic burden with the increasing categories of age and monthly income.

Conclusion:
With the nature of sedentary work (desk jobs), white-collar employees are at a greater risk of exposure to various NCDs than CDs and incur a significant amount of out-of-pocket expenditure to manage their health status.
Workplace Violence in Healthcare Settings: A Cross-Sectional Survey among Healthcare Workers of North India
Authors: Singh Amandeep , Ranjan Piyush , Agrawal Ramesh , Kaur Tanveer , Upadhyay Ashish D. , Nayer Jamshed , Chakrawarty Biswaroop , Sarkar Siddharth , Joshi Mohit , Kaur Tarang P. , Mohan Ajay , Chakrawarty Avinash , Kumar K. Raju 
Published: December 2023

Background:
Workplace violence (WPV) is a significant problem in both developed and developing countries, especially among healthcare workers. It has widespread implications for their overall health and well-being.

Objective:
The study was conducted to assess the problem of violence among doctors and other healthcare workers in healthcare settings.

Material and Methods:
A cross-sectional survey was conducted using a validated questionnaire from August 21 to September 18, 2021, based on purposive and snowball-sampling techniques for data collection. Appropriate statistical methods were applied to study the association between sociodemographics and characteristics of violence.

Results:
A total of 601 responses were analyzed. The results showed that approximately 75% of the participants experienced violence in some form at their workplace. These episodes lead to a significant impact on the physical and mental health of these workers. Around one-third of the participants felt uncomfortable reporting these incidents. Some of the most common risk factors and mitigation strategies were also reported by the participants.

Conclusion:
The findings of this study can be used by the legislators, administrators, and policymakers to develop strategies that can help in mitigating these episodes of violence for the better functioning of the healthcare system.
Risk of Silico-Tuberculosis in Miners: A Systematic Review and Meta-Analysis
Authors: Sinha Ratnesh , Priya Angelin , Ahmad Absar 
Published: December 2023

Context:
Tuberculosis (TB) and Silicosis are public health problems with high morbidity and mortality. They also exist as comorbidities and are highly prevalent among mine workers.

Aims:
This study aims to estimate the risk of TB in miners with silicosis than in miners not having silicosis.

Methods and Material:
This systematic review was conducted by literature search using PubMed, and EMBASE for studies published from 1st Jan 2017 till 20th July 2022. From the data obtained using relevant keywords for the search, a total of 345 articles were selected for screening after applying our inclusion-exclusion criteria and removing duplicates. PRISMA guidelines were followed. items JBI critical appraisal checklist for cross-sectional studies was used for assessment of the risk of bias. The odds ratio was used to estimate the strength of the association.

Results:
After extensive screening, four studies have met our selection criteria. The meta-analysis of those studies revealed that the prevalence of TB in miners with silicosis is 27.11% while the prevalence of TB in miners with non-silicosis is 16.75%. The estimated pooled odds ratio (fixed effect model) is 1.34 (95% CI 1.01 – 1.76).

Conclusions:
The present study reveals that there is an increased risk of TB in miners with Silicosis. Newer initiatives must be taken to prevent TB in miners.
Ergonomic and Anthropometric Evaluation of Locally Manufactured Vehicle Seats
Authors: Kumar Vikas , Oumer Kindu , Merso Eshetu A. , Sharma Rohit , Hira Jaspreet , Haldar Barun 
Published: December 2023

Background:
Most of the cars are imported as cargo vehicles and then converted into commercial passenger vehicles in Ethiopia. Seats are locally manufactured and installed as part of the conversion to passenger cars, with little regard permitted for the standard specifications required.

Objective:
A descriptive survey, an ergonomics assessment of passenger seats was conducted, and subjective evaluations of seat comfort were collected.

Methods and Materials:
For long journeys, there are problems of discomfort, back pain, and human fatigue. Anthropometric measurements of respondents and locally manufactured seats were used to conduct an objective evaluation of seat attributes.

Results:
The findings revealed that the passengers’ body proportions and the seat dimensions differ significantly and are not given any preference during design and fabrication of the seat.

Conclusion:
This study recommends the anthropometric dimensions of the Ethiopian passengers for the design and manufacturing of the vehicle seats.
A Comparative Study of Full Cuff Underlay and Over-underlay Tympanoplasty
Authors: Pandey Rajesh , Barnwal Abhishek Kumar , Yadav Anil Kumar 
Published: December 2023

Background:
Various modifications in tympanomeatal flap elevation in tympanoplasty were described by otolaryngologist all over the world to achieve best surgical outcome. In this study, the surgical and audiological outcomes of circumferential (full cuffed) tympanomeatal flap elevation and over-under technique of flap elevation were compared in type 1 tympanoplasty.

Objective:
The aim of this study is to compare surgical outcomes of two techniques of tympanomeatal flap elevation in tympanoplasty.

Materials and Methods:
This prospective randomized study included 200 patients. Patients were randomly allocated in 2 groups. Patients were followed for 3 months and compared surgical and audiological outcomes in 2 groups.

Results:
In full-cuffed underlay (Group A) techniques, the overall success (97.3%) and anterior blunting (9.1%) were more, whereas residual perforation (2.7%), granulation formation (2.7%), and lateralization (0.0%) were less common as compared to over-underlay technique (Group B). In over-underlay technique (Group B), success, residual perforation, lateralization, and anterior blunting were seen in 82.2%, 17.8%, 4.4%, and 2.2%, respectively.

Conclusion:
Both full-cuffed underlay and over-underlay techniques of tympanoplasty are effective surgical technique with satisfactory outcome.
Temporal Auditory Processing, Speech Recognition, and P300 in Adults with Opioid Use Disorders Attributed to Tramadol
Authors: Elnabtity Nadia Mohamed , Ibraheem Ola Abdallah , Galhom Dalia Helal 
Published: December 2023

Background:
Tramadol is a centrally acting opioid with an analgesic effect. Prolonged chronic pain management with tramadol and tramadol misuse may cause opioid use disorder attributed to tramadol (OUD-T). Evidence from pathophysiologic mechanisms of OUD-T raised the probability for central auditory processing abnormalities.

Objectives:
To our knowledge, no available studies evaluate the underlying pathology. Consequently, this study was designed to evaluate speech recognition, auditory temporal processing, auditory neurocognitive function in these patients.

Materials and Methods:
This work comprised a study group of 19 males with OUD-T and a control group of 19 participants, both with an age range of 20-40 years. All participants were subjected to (1) basic audiological evaluation, (2) psychoacoustic central auditory tests to assess auditory figure ground (speech intelligibility in noise) and temporal processing (Gaps-In-Noise and pitch pattern sequence), and (3) P300 neurocognitive potential.

Results:
OUD-T showed statistical significant depressed scores of speech in noise and pitch pattern sequence tests in comparison to the control group. In addition a statistically significant elevated GIN test approximate threshold and depressed total score was present in OUD-T. As regards P300, there was statistically significant difference between the control and the study group in latency and amplitude.

Conclusion:
These findings emphasize the importance of speech in noise, temporal processing, and neurocognitive evaluation in adults with opioid use disorder attributed to tramadol.
Comparison of Tympanoplasty Done with Removal of Posterior Canal Wall Skin versus Tympanoplasty Done with Preservation of Canal Wall Skin
Authors: Sayani Ruta K. , Oza Meshwa , Vadiya Sohil 
Published: December 2023

Aims and Objectives:
The aim of this study is to compare the outcomes of type 1 tympanoplasty in terms of graft uptake, hearing improvement, operative time, and healing time in patients operated with posterior canal skin preservation or without it.

Materials and Methods:
This is a prospective study of 100 patients operated for type 1 tympanoplasty surgery at a tertiary care hospital from August 2021 to June 2023 and operated by a single surgeon. Patients were divided into two groups and were randomly allocated (one with posterior canal skin preservation and other without it). Inclusion criteria were all patients operated for tympanoplasty between 12 and 50 years of age. Exclusion criteria were patients with mixed hearing loss or sensorineural hearing loss and patients who had to undergo ossicular chain reconstruction and revision cases were also excluded from the study. The outcomes were evaluated on follow-up by otoendoscopy and pure-tone audiometry.

Observation and Discussion:
In terms of graft uptake at 3-month postoperative period, no significant difference was found between both the groups. In terms of hearing improvement and healing time, P > 0.1 was noted, and hence the difference was not significant. However, the operative time was significantly lower for the group with posterior canal wall skin removal.

Conclusion:
Removal of skin from posterior surface of external auditory canal improves visualization during tympanoplasty. It reduces operative time and provides same success rates in terms of graft uptake and hearing improvement. It has almost the same healing time, and granulations or other canal-related complications are minimal. Graft medialization or lateralization is also minimal when anterior tucking and lateral tucking of graft is done.