bluuebunny/crossref_metadata_2025_split huggingface dataset:
The Importance of Preventive Measures against Epidemic Diseases from the Perspective of Islamic Law
Authors: Moheb Mohammad Mansour 
Published: October 2023

This article explores the importance of preventive measures against epidemic diseases from the perspective of Islamic law. It first clarifies the concept of preventive measures and then delves into their significance and strategies based on Islamic law. The text emphasizes preserving human health and safety from deadly diseases, highlighting the importance of cleanliness and environmental hygiene, including maintaining personal hygiene, wearing clean clothes, medical isolation, and environmental cleanliness.
According to the teachings of Islamic sacred law, it can be said that the best preventive measures are guided by medical advice in Islamic law. Adhering to these measures consistently helps humans remain protected from widespread diseases such as COVID-19, Ebola, and others. Strategies such as medical treatment and the use of authorized medicines, quarantine, and medical isolation (avoiding social interactions when afflicted with diseases) are some of the most effective preventive measures, emphasized and recommended by Islamic teachings. Failure to comply with these measures is considered contrary to religious dictates and endangers human life. Since safeguarding human life is considered one of the primary objectives of Islamic law, everyone is obligated to adhere to preventive measures based on both religious teachings and medical guidelines. By following these measures, individuals can protect their communities from devastating epidemic diseases.
Editorial
Authors: Valenzuela Muñoz Alberto 
Published: October 2023

La Revista de Investigación Científica Huamachuco, publicada semestralmente por la Universidad Nacional Ciro Alegría (UNCA), tiene como objetivo difundir contribuciones originales e inéditas de autores nacionales e internacionales que resultan de investigaciones científicas y tecnológicas.
Esta revista está dirigida a investigadores, estudiantes, académicos y profesionales con competencia e intereses en las ciencias sociales y aplicadas, adoptando un enfoque multidisciplinario. Los hallazgos presentados en la revista aportan relevancia e impacto tanto para la comunidad científica como para el sector empresarial y la sociedad en general.
TTC13 expression and STAT3 activation may form a positive feedback loop to promote ccRCC progression
Authors: Xie Lingling , Fang Yu , Chen Jianping , Meng Wei , Guan Yangbo , Gong Wenliang 
Published: October 2023

Background
Renal cell carcinoma (RCC) originates from renal tubular epithelial cells and is mainly classified into three histological types, including clear cell renal cell carcinoma (ccRCC) which accounts for about 75% of all kidney cancers and is characterized by its strong invasiveness and poor prognosis. Hence, it is imperative to understand the mechanisms underlying the occurrence and progression of ccRCC to identify effective biomarkers for the early diagnosis and the prognosis prediction.

Methods
The mRNA level of TTC13 was quantified by RT-PCR, while the protein level was determined by western blot and immunohistochemistry (IHC) staining. Cell proliferation was measured by cck-8, and cell apoptosis was detected by flow cytometry. The binding of STAT3 to the promoter region of TTC13 was determined by the luciferase reporter assay and chip experiments. STAT3 nuclear translocation was assessed by immunofluorescence staining.

Results
We found that TTC13 was up-regulated in ccRCC, and TTC13 promoted cell proliferation as well as inhibited cell apoptosis and autophagy of ccRCC through wnt/β-catenin and IL6-JAK-STAT3 signaling pathways. Furthermore, TTC13 might play a role in the immune infiltration and immunotherapy of ccRCC. Mechanistically, STAT3 activated the transcription of TTC13 gene.

Conclusions
STAT3 directly regulated TTC13 expression through a positive feedback loop mechanism to promote ccRCC cell proliferation as well as reduce cell apoptosis and autophagy. These findings suggested new and effective therapeutic targets for more accurate and personalized treatment strategies.
Idiopathic Pulmonary Hemosiderosis in Pediatric in Patients: Report of Four Cases in Rabat, Morrocco
Authors: Benchidmi S.  , Lamghari Y.  , Saad A.  , Maalmi N.  , Jaabouti G.  , Aminou S.  , Elqoraichi O.  , EL Hafidi N.  , Mahraoui C.  , Benchekroun S.  
Published: October 2023

Idiopathic pulmonary hemosiderosis (IPH) is a rare cause of diffuse alveolar hemorrhage. Patients with IPH usually present with the classical triad: hemoptysis, and iron deficiency anemia, and pulmonary infiltrates on chest imaging, the diagnosis is often delayed by years.
We report four IPH pediatrics cases of children diagnosed at the children’s hospital of Rabat, Morocco. The aim of this study is to review the clinical manifestations, diagnostic tools and treatment of this affection.
All the four patients were presented with the classical triad, the diagnosis was based on the Clinical, radiologic and biologic findings. Bronchoalveolar lavage was performed to all the patients and confirmed the diagnosis by the identification of siderophages.
High doses of Corticosteroids, by an induction therapy with an intravenous methylprednisolone (20 mg/kg/day for 3 days) followed by oral prednisone (1 mg/kg/day) had shown a good therapeutic response. One patient was treated first with oral corticosteroid and switched over to synthetic antimalarial drugs, because he had side effects from long-term cortico therapy. Then the clinical condition has been improved. The evaluation of response to the therapy included the clinical symptoms and signs, laboratory data and chest x ray. The prognosis of IPH is influenced by several factors, including the time of diagnosis, early initiation of treatment, and the presence of comorbidities.
Temperature‐Driven Topological Transformations in Prestressed Cellular Metamaterials
Authors: Yang Hang , Wang Wei‐Jie , Zhu Jun‐Zhe , Ma Li , Pasini Damiano , Zhai Wei 
Published: January 2025

AbstractStimuli‐responsive materials are able to alter their physicochemical properties, e.g., shape, color, or stiffness, upon exposure to an external trigger, e.g., heat, light, or humidity, exhibiting environmental adaptability. Their capacity to undergo shape reconfiguration, pattern transformation, and property modulation enables multifunctionality. In this work, two strategies are harnessed, i.e., prestressed assembly and temperature‐dependent stiffness reversal, to introduce a class of temperature‐responsive metamaterials capable of undergoing topological transformations, endowing them with smart functionality. Through a combination of mechanics theory, numerical simulations, and thermomechanical experiments, the physical mechanisms underlying the temperature‐triggered topological transformations leading to pattern switches are first elucidated, and then the insights are leveraged to demonstrate tunable bandgaps and robotic capturers. These findings reveal the attainment of giant negative and positive values of coefficient of thermal expansion, accompanied by isotropic expansion and shrinkage under thermal actuation within a fairly rapid timeframe, below 6 s. The strategy here presented is versatile as it relies on a pair of off‐the‐shelf 3D printable materials, can be up‐ and down‐scaled, and can also be realized through other physical stimuli, e.g., light and moisture, paving the way for use in multifunctional applications, including stimulus‐triggered morphing devices, autonomous sensors and actuators, and reconfigurable soft robots.
An Iron‐Polyphenol Decorated siRNA‐Encapsulated Nanomedicine Multifacetedly Promoted Macrophage Phagocytosis for Synergistic Ferroptosis‐Immunotherapy
Authors: Yu Boya , Xiao Zekai , Shao Shuaiqi , Yang Mingda , Jing Houjin , Shen Song , Cao Ziyang , Yang Xianzhu 
Published: January 2025

AbstractMacrophages are vital components of the innate immune system, capable of directly engulfing tumor cells. However, tumor cells can cunningly evade recognition and phagocytosis by macrophages. In light of this, an iron‐polyphenol‐decorated poly(ethylene glycol)‐poly(lactic‐co‐glycolic acid (PEG‐PLGA) nanoparticle has been developed with efficient siRNA encapsulation (NPsiCD47@Fe‐TA) to trigger the ferroptosis in tumor cell and also elicit the macrophage‐mediated immunotherapy. The Fe‐TA (Tannic acid) shell of NPsiCD47@Fe‐TA induces the ferroptosis in tumor cell, which consequently produces oxygenated phosphatidylethanolamine 1‐steaoryl‐2‐15‐HpETE‐sn‐glycero‐3‐phosphatidylethanolamine (SAPE‐OOH) in the cell membrane and achieve the surface exposure of calreticulin (CRT). Meanwhile, the encapsulated siCD47 of NPsiCD47@Fe‐TA efficiently down‐regulates the CD47 receptor in the tumor cell membrane. The exposure of SAPE‐OOH and CRT in the cell membrane and down‐regulation of CD47 receptor remarkably promoted the phagocytosis of tumor cells by macrophage and elicited the systemic anticancer immune response. Eventually, the NPsiCD47@Fe‐TA can efficiently suppress the tumor growth. Moreover, after combination with immune checkpoint blockade (ICB) antibody, NPsiCD47@Fe‐TA remarkably inhibits tumor progress and metastasis in the cold triple‐negative 4T1 breast cancer model.
Photocontrolled Bionic Micro‐Nano Hydrogel System used Novel Functional Strategy for Cell Delivery and Large‐Scale Corneal Repair
Authors: Zhang Mingshan , Zhang Shi‐yao , Zhang Huiqin , Liu Youwei , Dong Yipeng , Han Daobo , Chang Le , Yang Ning , Tian Jianguo , Wang Yan , Ye Qing 
Published: January 2025

AbstractReproducing the microstructure of the natural cornea remains a significant challenge in achieving the mechanical and biological functionality of artificial corneas. Therefore, the development of cascade structures that mimic the natural extracellular matrix (ECM), achieving both macro‐stability and micro‐structure, is of critical importance. This study proposes a novel, efficient, and general photo‐functionalization strategy for modifying natural biomaterials. Collagen microfibers obtained through electrospinning are functionalized with an active N‐Hydroxysuccinimide (NHS) ester, to impart light‐curing ability. This approach expands the construction of photo‐controllable hydrogel systems beyond conventional single methacrylate (MA) modifications or di‐tyrosine bonding, enabling integration with other biomaterials for comprehensive ECM remodeling. Subsequently, the collagen microfibers are then photo‐embedded into gelatin methacryloyl (GelMA) via covalent crosslinking to form a fibrous hydrogel, which supports both structural and functional requirements. In terms of biological functionality, the hydrogel promotes significant inward migration and retention of human corneal fibroblasts (hCFs), replicating ECM‐like environments. Furthermore, its excellent burst resistance suggests potential as a bioadhesive. In a rabbit model, the hydrogel achieved effective repair of large‐sized (6 mm) corneal defects, facilitates epithelial migration, and maintained long‐term stability. This work provides valuable guidance for designing efficient and simplified bioactive materials for corneal repair and broader tissue engineering applications.
Ultrahigh Exchange Bias Field/Coercive Field Ratio in In Situ Formed Two‐Dimensional Magnetic Te‐Cr2O3/Cr5Te6 Heterostructures
Authors: Yi Chen , Li Zhou , Li Qiuqiu , Li Bailing , Zhang Hongmei , He Kun , Zhang Liqiang , Zhang Zucheng , Feng Ya , Liu Yingying , Liu Miaomiao , Wang Di , Li Shanhao , Tang Jingmei , Gao Peng , Zhu Manli , Wang Yanru , Wu Ruixia , Li Jia , Liu Xingqiang , Chen Shulin , Ma Chao , Liu Yuan , Wei Zhongming , Liao Lei , Li Bo , Duan Xidong 
Published: January 2025

AbstractThe exchange bias (EB) effect is a fundamental magnetic phenomenon, in which the exchange bias field/coercive field ratio (|HEB/HC|) can improve the stability of spintronic devices. Two‐dimensional (2D) magnetic heterostructures have the potential to construct low‐power and high‐density spintronic devices, while their typically air unstable and |HEB/HC| lesser, limiting the possibility of applications. Here, 2D Cr5Te6 nanosheets have been systematically synthesized with an in situ formed ≈2 nm‐thick Te doped Cr2O3 layer (Te‐Cr2O3) on the upper surface by chemical vapor deposition (CVD) method. The strong and air stable EB effect, achieving a |HEB/HC| of up to 80% under an ultralow cooling field of 0.01 T, which is greater than that of the reported 2D magnetic heterostructures. Meanwhile, the uniformity of thickness and chemical composition of the Te‐Cr2O3 layer can be controlled by the growth conditions which are highly correlated with the EB effect of 2D Te‐Cr2O3/Cr5Te6 heterostructures. First‐principles calculations show that the Te‐Cr2O3 can provide uncompensated spins in the Cr2O3, thus forming strong spin pinning effect. The systematical investigation of the EB effect in 2D Te‐Cr2O3/Cr5Te6 heterostructures with high |HEB/HC| will open up exciting opportunities in low‐power and high‐stability 2D spintronic devices.
Monolithic Multiparameter Terahertz Nano/Microdetector Based on Plasmon Polariton Atomic Cavity
Authors: Chen Huanjun , Wang Ximiao , Liu Shaojing , Cao Zhaolong , Li Jinyang , Zhu Hongjia , Li Shangdong , Xu Ningsheng , Deng Shaozhi 
Published: January 2025

AbstractTerahertz (THz) signals are crucial for ultrawideband communication and high‐resolution radar, demanding miniaturized detectors that can simultaneously measure multiple parameters such as intensity, frequency, polarization, and phase. Traditional detectors fail to meet these needs. To address this, we introduce a plasmon polariton atomic cavity (PPAC) detector based on monolayer graphene, offering a multifunctional, monolithic, and miniaturized solution. With a footprint only one‐tenth the size of the incoming wavelength, the PPAC achieves benchmark performance in intensity‐, frequency‐, and polarization‐sensitive detection. Operating at room temperature across 0.22–4.24 THz, it delivers sub‐diffraction detection resolution and high‐speed operation. Furthermore, we demonstrate its application in free‐space THz polarization‐coded communication and stealth imaging for physical property analysis. The unique design of PPAC enables strong absorption with weak signal detection, within a structure just 10−5 times the excitation wavelength in thickness, an accomplishment beyond current technologies. By simultaneously resolving intensity, frequency, and polarization, this detector can replace multiple single‐function devices, providing a compact and efficient solution for next‐generation ultrawideband communication and high‐resolution radar systems.
Electroactive Dressing with Selective Sorption of Exudate Enables Treatment of Complicated Wound
Authors: Wang Yuanbin , Ma Qian , Zheng Bingna , Xiong Wenxuan , Miao Dongtian , Li Yong , Huang Rongkang , Wang Hui , Wu Dingcai 
Published: January 2025

AbstractExudate management and cell activity enhancement are vital to complicated wound healing. However, current exudate management dressings indiscriminately remove exudate, which is detrimental to cell activity enhancement. Herein, a novel class of electroactive bilayer (cMO/PVA) dressing is developed by constructing manganese oxide nanoneedle‐clusters decorated commercial carbon cloth (MO), in situ casting polyvinyl alcohol (PVA) hydrogel, and finally charging. Benefitting from the hierarchical nanoneedle‐cluster structure of MO, abundant active sites are sufficiently exposed to achieve high area‐specific capacitances (e.g., 1881.3 mF cm−2), thereby establishing the long‐lasting electric field for cMO/PVA dressing. Such a unique cMO/PVA dressing can realize extraordinary selective sorption toward noxious substances over nutrient substances during exudate management. Meanwhile, its long‐term electrical stimulation therapy can promote cell proliferation and migration and enhance antibacterial property. As a result, our multifunctional cMO/PVA dressing can rapidly repair full‐thickness wounds in type II diabetic rats, offering an advanced strategy for the treatment of complicated wounds.
Ultrathin Rare‐Earth Oxyhalides as High‐κ van der Waals Layered Dielectrics
Authors: Liu Zijia , Yin Lei , Peng Ximeng , Zhou Yanchang , Zhai Baoxing , Yu Yiling , Cheng Ruiqing , Wen Yao , Jiang Jian , Feng Xiaoqiang , Wang Fang , He Jun 
Published: January 2025

AbstractVan der Waals (vdW) dielectrics are extensively employed to enhance the performance of 2D electronic devices. However, current vdW dielectric materials still encounter challenges such as low dielectric constant (κ) and difficulties in synthesizing high‐quality single crystals. 2D rare‐earth oxyhalides (REOXs) with exceptional electrical properties present an opportunity for the exploration of novel high‐κ dielectrics. In this study, for the first time, the synthesis of a series of van der Waals layered gadolinium oxyhalides with thicknesses down to monolayer through a space‐confined vdW epitaxy approach and demonstrating their application as a single‐crystalline gate dielectric is reported. It exhibits a remarkable relative dielectric constant exceeding 17 and an impressive breakdown field strength of 13.5 MV cm−1. The 2D transistors directly gated by the REOXs layer exhibit enhanced electron mobility and a low interface trap density. An ultrahigh on/off current ratio of 109 and a near‐Boltzmann‐limit subthreshold swing is achieved. The superior dielectric properties, combined with the universality and scalability of the production method (e.g., millimeter‐scale films are achieved), demonstrate that 2D REOXs can serve as promising gate dielectrics for 2D electronics, thereby expanding the study of high‐κ vdW materials and potentially providing new opportunities for the development of low‐power electronic devices.
Lighting the Path to Precision Healthcare: Advances and Applications of Wearable Photonic Sensors
Authors: Song Ruihao , Cho Seokjoo , Khan Shadman , Park Inkyu , Gao Wei 
Published: January 2025

AbstractRecent advancements in wearable photonic sensors have marked a transformative era in healthcare, enabling non‐invasive, real‐time, portable, and personalized medical monitoring. These sensors leverage the unique properties of light toward high‐performance sensing in form factors optimized for real‐world use. Their ability to offer solutions to a broad spectrum of medical challenges – from routine health monitoring to managing chronic conditions, inspires a rapidly growing translational market. This review explores the design and development of wearable photonic sensors toward various healthcare applications. The photonic sensing strategies that power these technologies are first presented, alongside a discussion of the factors that define optimal use‐cases for each approach. The means by which these mechanisms are integrated into wearable formats are then discussed, with considerations toward material selection for comfort and functionality, component fabrication, and power management. Recent developments in the space are detailed, accounting for both physical and chemical stimuli detection through various non‐invasive biofluids. Finally, a comprehensive situational overview identifies critical challenges toward translation, alongside promising solutions. Associated future outlooks detail emerging trends and mechanisms that stand to enable the integration of these technologies into mainstream healthcare practice, toward advancing personalized medicine and improving patient outcomes.
Engineering Group VI Transition Metal Dichalcogenides for Designing Various Sensors
Authors: Zhang Zherui , Wu Yichen , Xie Lingbin , Zhu Xianjun , Wang Longlu 
Published: January 2025

AbstractRecent advancements in sensor technology are driven by progress in materials science and increasing demands from applications such as health diagnostics. Particularly, with the push from nanotechnology and biocompatible materials, sensor technology has made significant progress. Sensor applications have been greatly enhanced by the unique properties of transition metal dichalcogenides (TMDs). These high‐performance sensors not only improve the accuracy of measurements but also provide robust support for real‐time data analysis. To further demonstrate the latest advancements in sensor technology, this paper specifically introduces the recent researches of sensors based on WS2, MoS2, and their composites. Herein, the structures and the properties of TMDs are systematically described, highlighting their strong potential for advancing sensor development. Then, the recent progress of Group VI TMDs in various sensor domains, including humidity sensors, temperature sensors, gas sensors, biosensors, image sensors, and strain sensors, is further discussed. Through detailed analysis of the function and performance of Group VI TMDs in these areas, this paper aims to emphasize their advantages as sensor materials. The performance of TMDs in various sensor applications is also systematically summarized, and a glimpse into what the future holds for sensors using TMDs is offered.
Optically Pumped Ultrafast and Broadband Terahertz Modulation with Scalable Molecular Beam Epitaxy Grown MoTe2/Si Heterostructures
Authors: Ghosh Suprovat , Bhattacharya Kritika , Sasmal Sujan , Bhatt Kamlesh , Kandar Santanu , Khan Biswajit , Luo Chih‐Wei , Singh Rajendra , Basu Ananjan , Das Samaresh 
Published: January 2025

AbstractDespite advancements in terahertz (THz) modulators, achieving a balance between large modulation depth (MD) and fast modulation speed in scalable devices remains a significant challenge. Optically pumped THz modulators with high MD, broad bandwidth, and fast response times are essential for progress in THz technology. Here, scalable MoTe2/Si van der Waals (vdW) heterostructures are grown via molecular beam epitaxy (MBE) as an optically pumped THz modulators, leveraging its favorable band alignment and seamless integration with silicon complementary metal‐oxide semiconductor (CMOS) technology. High‐quality bilayer, 5‐layer, and 7‐layer MoTe2 films are grown on high‐resistivity silicon, with the bilayer modulator achieving a maximum 74.6% modulation depth under 355 nm illumination of 4.8 W mm−2 at 0.25 THz. The bilayer device exhibited fast rise and fall times of 1.8 and 0.6 µs, respectively, and provided broadband modulation across the 0.1 to 1.0 THz range. Furthermore, this work demonstrates that higher modulation depth significantly enhances THz imaging quality with promising applications in detecting pharmaceutical forgeries. Overall, these ultrafast, broadband THz modulators provide a promising route for advancing next‐generation THz technology, enhancing applications in wireless communication, precision detection, and high‐resolution THz imaging, fostering future innovation.