bluuebunny/crossref_metadata_2025_split huggingface dataset:
Chimeric antigen receptor and bispecific T‐cell engager therapies in multiple myeloma patients with prior allogeneic transplantation
Authors: Hammons Lindsay , Haider Shabi , Portuguese Andrew J. , Banerjee Rahul , Szabo Aniko , Pasquini Marcelo , Chhabra Saurabh , Radhakrishnan Sabarinath , Mohan Meera , Narra Ravi , Dong Jing , Janz Siegfried , Shah Nirav N. , Hamadani Mehdi , D'Souza Anita , Hari Parameswaran , Dhakal Binod 
Published: December 2023

SummaryChimeric antigen receptor T‐cell (CAR‐T) therapy and bispecific T‐cell engagers (BsAb) have emerged as promising immunotherapeutic modalities in patients with relapsed and/or refractory multiple myeloma (RRMM). However, there is limited data on the safety and efficacy of CAR‐T and BsAb therapies in MM patients with a prior history of allogeneic transplantation (allo‐HCT). Thirty‐three MM patients with prior allo‐HCT received CAR‐T (n = 24) or BsAb (n = 9) therapy. CAR‐T therapy demonstrated an ORR of 92% (67% ≥ CR), and 73% were MRD negative. BsAb therapy resulted in an ORR of 44% (44% ≥ CR) and 44% MRD negative. Safety analysis showed grade ≥3 AEs in 92% of CAR‐T and 56% of BsAb patients. Cytokine release syndrome (CRS) occurred in 83% of CAR‐T and 78% of BsAb recipients, while immune effector cell‐associated neurotoxicity syndrome (ICANS) was observed in three CAR‐T patients. Infections of grade ≥3 were reported in 50% of CAR‐T and 44% of BsAb recipients. No exacerbation of graft‐versus‐host disease occurred except in one BsAb recipient. CAR‐T and BsAb therapies appear to be feasible, safe and provide deep and durable responses in MM patients with prior allo‐HCT.
Records of quality indicators for management of long‐term health conditions of patients with intellectual disabilities in Dutch residential care
Authors: van den Bemd Milou , Suichies Viviana , Bischoff Erik , Leusink Geraline L. , Cuypers Maarten 
Published: December 2023

AbstractBackgroundType 2 diabetes mellitus, cardiovascular disease and chronic obstructive pulmonary disease contribute significantly to societal and individual impact globally. High‐quality management of these long‐term health conditions is important to prevent deterioration of health, although potentially more complex for patients with intellectual disabilities in residential care. Disease management in this context particularly benefits from complete and accurate recording of disease management. Without complete records, long‐term health conditions are more difficult to track due to the level of uncertainty regarding which clinical examinations have and have not been performed. This study therefore aims to examine the recording routines of quality indicators for disease monitoring for chronically ill patients with intellectual disabilities in Dutch residential care.MethodsThis retrospective study utilised medical record data from a large Dutch long‐term care provider. We assessed the occurrence of cardiovascular disease (ICPC‐2 codes K74, K75, K76, K89 and K90), type 2 diabetes mellitus (T90, T90.02) and/or COPD (R91, R95). For adults with intellectual disabilities and long‐term condition, we analysed data entries in an 18‐month period (between July 2020 and December 2021). Observed consultation rates were calculated and presented in median with interquartile range and contrasted against the baseline number of consultations in primary care. Information on recorded quality indicators was presented in frequencies and percentages.FindingsOf the three long‐term conditions investigated, the most common was type 2 diabetes mellitus (8.6%; n = 287), followed by cardiovascular disease (5.8%; n = 195) and COPD (3.0%; n = 101). Of those who received management for their long‐term condition from their contracted GP, patients with type 2 diabetes mellitus, cardiovascular disease, or COPD had fewer consultations in 2021 than the Dutch baseline. Discussion of lifestyle was often not recorded. Disease monitoring quality indicators were recorded more often but at a lower frequency than expected.ConclusionsBecause of the infrequent recording of quality indicators, recording of management of long‐term conditions for patients with intellectual disabilities in long‐term care appears suboptimal. Although this may not directly harm individual patients, it may jeopardise the quality of management of long‐term conditions, as suboptimal recording limits opportunities for evaluation and improvement. Within a broader trend towards data‐driven work methods in healthcare, recording of quality indicators requires attention from practice, research and policy.
Gift and stewardship: Two ambiguous concepts in the religious discourse on nature
Authors: Henriksen Jan‐Olav 
Published: December 2023

AbstractAmong the misleading conceptions that may prevent adequate action to mitigate the consequences of climate change are two predominant views: the understandings of nature as a gift and of humans as stewards of creation. This article discusses these conceptions critically before suggesting alternative ways to understand humanity's place in and activity with nature. The constructive proposals at the end are based on insights from philosopher G.W.F. Hegel on the need to see ourselves as part of a unity with nature, and theologian I.U. Dalferth, who provides a basis for another type of sensitivity for nature that is not based merely in human activity, but also in the need for passivity and the recognition of our finitude.
A cytochrome P450 insecticide detoxification mechanism is not conserved across the Megachilidae family of bees
Authors: Hayward Angela , Hunt Benjamin J. , Haas Julian , Bushnell‐Crowther Ellie , Troczka Bartlomiej J. , Pym Adam , Beadle Katherine , Field Jeremy , Nelson David R. , Nauen Ralf , Bass Chris 
Published: December 2023

AbstractRecent work has demonstrated that many bee species have specific cytochrome P450 enzymes (P450s) that can efficiently detoxify certain insecticides. The presence of these P450s, belonging or closely related to the CYP9Q subfamily (CYP9Q‐related), is generally well conserved across the diversity of bees. However, the alfalfa leafcutter bee, Megachile rotundata, lacks CYP9Q‐related P450s and is 170–2500 times more sensitive to certain insecticides than bee pollinators with these P450s. The extent to which these findings apply to other Megachilidae bee species remains uncertain. To address this knowledge gap, we sequenced the transcriptomes of four Megachile species and leveraged the data obtained, in combination with publicly available genomic data, to investigate the evolution and function of P450s in the Megachilidae. Our analyses reveal that several Megachilidae species, belonging to the Lithurgini, Megachilini and Anthidini tribes, including all species of the Megachile genus investigated, lack CYP9Q‐related genes. In place of these genes Megachile species have evolved phylogenetically distinct CYP9 genes, the CYP9DM lineage. Functional expression of these P450s from M. rotundata reveal they lack the capacity to metabolize the neonicotinoid insecticides thiacloprid and imidacloprid. In contrast, species from the Osmiini and Dioxyini tribes of Megachilidae have CYP9Q‐related P450s belonging to the CYP9BU subfamily that are able to detoxify thiacloprid. These findings provide new insight into the evolution of P450s that act as key determinants of insecticide sensitivity in bees and have important applied implications for pesticide risk assessment.
Evaluation of phubbing online social support and trait anxiety in nurses
Authors: Şafak Ayşegül , Oflaz Fahriye 
Published: December 2023

AbstractAimThis study investigated the relationship between phubbing, online social support, trait anxiety, and some demographic factors among nurses.BackgroundPhubbing, or socializing through online smartphone applications, has become increasingly prevalent in healthcare environments, potentially threatening real‐life interactions. We aimed to explore the use of smartphones among nurses, both professionally and socially, and to determine if increased usage was leading to interaction problems.MethodsThis cross‐sectional study was conducted using a digital survey completed by 384 nurses between May and November 2021. The survey included an individual descriptive form, the generic scale of phubbing, the online social support scale, and the trait anxiety inventory. Mann–Whitney U, Kruskal–Wallis H, t test, Pearson, and the Spearman rank correlation coefficient were used for analysis. A backward selection method regression analysis was performed to determine the variables affecting the phubbing score. The “STROBE checklist” for cross‐sectional studies was utilized in order to report the findings of the study.ResultsThe participants had a moderate level of trait anxiety. The study found that marital status, having WhatsApp groups with teammates, and being warned about phone use from teammates were significantly related to phubbing. A moderate positive correlation was found between the phubbing score and the online social support score. Additionally, a weak positive correlation was found between the general phubbing and trait anxiety scores.ConclusionsPerceived online social support significantly influenced the phubbing behavior of nurses and trait anxiety played a mediating role in this relationship.Implications for nursing and policyNurses frequently use smartphones for professional purposes, but this study found that excessive phone use can be detrimental to their social interactions. Moreover, phubbing could also be problematic for patients. Therefore, healthcare professionals need to be aware of the potential consequences of smartphone usage and the importance of limiting excessive use during patient care.
Enhancement of superior dielectric performance in ZnTiNb2O8 systems by multi‐layer architecture
Authors: Huang Zipeng , Qiao Jianli , Li Lingxia 
Published: December 2023

AbstractZn0.995Cu0.005TiNb2O8@TiO2 mixed ceramics and Zn0.995Cu0.005TiNb2O8‐TiO2‐Zn0.995Cu0.005TiNb2O8 layered ceramics with different TiO2 contents were designed and manufactured to adjust the microwave dielectric performances of Zn0.995Cu0.005TiNb2O8/TiO2 composite ceramics. The effects of random distribution and laminated co‐firing processes on the microwave dielectric properties of the ZnTiNb2O8 systems were fully investigated and compared. During the random distribution process, the compound transforms from the original ZnTiNb2O8 phase to the Zn0.17Nb0.33Ti0.5O2 phase with the increase of TiO2 content. Its value can be adjusted to near zero, but its Q× f value decreases severely. For the laminated co‐firing process, the distinctive tri‐layer architecture allows the reaction between Zn0.995Cu0.005TiNb2O8 and TiO2 to be limited to a narrow region of about 20 µm width and can play a role similar to that of “glue” to connect the layers well. The process significantly minimizes the probability of Q× f values deteriorating. Compared with the random distribution Zn0.995Cu0.005TiNb2O8@TiO2, the Q× f value of the tri‐layer architecture ceramics is improved by about 85% with no significant decrease in dielectric permittivity while ensuring high‐temperature stability. When stacked with 0.04 wt% TiO2, the Zn0.995Cu0.005TiNb2O8‐TiO2‐Zn0.995Cu0.005TiNb2O8 tri‐layer architecture ceramic exhibits superior dielectric properties: = 39.96, Q× f = 51,987 GHz, and = ‐1.31 ppm/°C.
Statistical evaluation of the mechanical and flux trapping properties of standard and thin‐wall EuBCO(Ag) bulk superconductors
Authors: Baumann Josef , Lojka Michal , Dennis Anthony , Shi Yunhua , Durrell John H. , Hlásek Tomáš , Cardwell David A. 
Published: December 2023

AbstractThe mechanical and flux trapping properties of 19 EuBCO(Ag) and 20 thin‐wall EuBCO(Ag) bulk superconductors were investigated statistically and compared to those observed for YBCO using Brazilian testing and high‐field magnetization. The average trapped fields of EuBCO(Ag) and thin‐wall EuBCO(Ag) bulk superconductors were significantly higher than those of YBCO bulk samples at 77 K measured under similar experimental conditions. However, due to the wide range of trapped field data for both materials, a statistical overlap was observed between the highest trapped fields observed for YBCO and the lowest values observed for EuBCO(Ag) bulk superconductors. All EuBCO(Ag) bulk materials measured in this study exhibit a superior tensile strength compared to YBCO bulk single grains. Unlike the case of YBCO, however, the introduction of artificial holes to EuBCO(Ag) bulk superconductors prior to melt processing was observed to decrease the average tensile strength of the single grain. Surprisingly, despite their superior mechanical and flux pinning properties, EuBCO(Ag) bulk superconductors do not exhibit enhanced performance when exposed to high fields at low temperatures.
Is shrunken pore syndrome also a reality in children?
Authors: Roussel Mathilde , Bacchetta Justine , Sellier‐Leclerc Anne Laure , Lemoine Sandrine , De Mul Aurélie , Derain Dubourg Laurence 
Published: December 2023

AbstractBackgroundShrunken pore syndrome (SPS) is defined as cystatin C‐based‐eGFR (eGFRcys)/creatinine‐based‐eGFR (eGFRcreat) <0.6 or 0.7 and is associated with an increased cardiovascular risk. SPS has been described in children, but no link to increased morbi‐mortality was demonstrated.ObjectivesStudy the prevalence of SPS in a pediatric population using several glomerular filtration rate (GFR) estimating formulas and measured GFR and evaluate the potential link with cardiovascular risk.MethodsIn 307 renal risk pediatric patients, we studied prevalence of SPS either with CKiDU25creat and cyst or with FAScreat and cyst and EKFCcreat. The characteristics of patients with SPS (defined with Full‐age spectrum equation (FAS) and/or European Kidney Function Consortium equation (EKFC)) were compared.Results and conclusionThe prevalence of SPS varies widely depending on the threshold and the formulas used. Higher C‐reactive protein (CRP) and phosphate levels and smaller size are observed in children with SPS defined with FAS and/or EKFC and might be associated with long‐term increased cardiovascular risk. Further studies in wider general pediatric populations are warranted.
Prevalence of eunatremic, eukalemic hypoadrenocorticism in dogs with signs of chronic gastrointestinal disease and risk of misdiagnosis after previous glucocorticoid administration
Authors: Tardo Antonio Maria , Del Baldo Francesca , Leal Rodolfo Oliveira , Galiazzo Giorgia , Pietra Marco , Gaspardo Alba , Fracassi Federico 
Published: December 2023

AbstractBackgroundDogs with eunatremic, eukalemic hypoadrenocorticism (EEH) typically show signs of chronic gastrointestinal disease (CGD). Previous glucocorticoid administration (PGA) can give false‐positive results on the ACTH stimulation test (ACTHst).Hypothesis/ObjectivesTo determine the prevalence of EEH in dogs with signs of CGD, and to identify clinical and clinicopathological features for EEH and PGA.AnimalsOne hundred twelve dogs with CGD (101 non‐PGA and 11 PGA), 20 dogs with EEH.MethodsMulticenter prospective cohort study. Basal serum cortisol (BSC) concentration was measured in dogs with signs of CGD. When BSC was <2 μg/dL and in PGA dogs, ACTHst plus measurement of endogenous ACTH (eACTH) were performed. Records of dogs with EEH from 2009 to 2021 were reviewed.ResultsThe BSC concentration was <2 μg/dL in 48/101 (47.5%) non‐PGA and in 9/11 (82%) PGA dogs. EEH was diagnosed in 1/112 dog (prevalence 0.9%; 95% CI, 0.1%‐4.8%); the ACTHst provided false‐positive results in 2/11 PGA dogs. PGA dogs showed lower C‐reactive protein‐to‐haptoglobin ratio (median 0.01, range 0.003‐0.08; P = .01), and higher haptoglobin (140, 26‐285 mg/dL; P = .002) than non‐PGA dogs (0.04, 0.007‐1.5; 38.5, 1‐246 mg/dL, respectively). eACTH was higher (P = .03) in EEH (396, 5‐>1250 pg/mL) than in non‐PGA dogs (13.5, 7.3‐46.6 pg/mL). Cortisol‐to‐ACTH ratio was lower (P < .0001 and P = .01, respectively) in EEH (0.002, 0.0002‐0.2) than in non‐PGA (0.1, 0.02‐0.2) and PGA dogs (0.1, 0.02‐0.2).Conclusions and Clinical ImportanceThe prevalence of EEH in dogs with signs of CGD was lower than previously reported. The clinical and clinicopathological features herein identified could increase the index of suspicion for EEH or PGA in dogs with an unclear history of glucocorticoid administration.
Deteriorating complementary feeding practices and dietary quality in Jordan: Trends and challenges
Authors: Ghosh Shibani , Shrestha Robin , Ren Yanlin , Salve Karuna , Webb Patrick 
Published: December 2023

AbstractQuality complementary feeding (CF) of infants and young children is key to their growth and development. But in Jordan, providing appropriate CF remains a challenge. This study assesses trends in infant and young child feeding (IYCF) practices, and consumption by infants and young children aged 6–23 months of breast milk substitutes (BMSs), sugar‐sweetened beverages (SSBs), and micronutrient‐rich foods in Jordan from 1990 to 2017. We combined dietary data on infants and young children from six Demographic and Health Surveys (DHS) (n = 14,880 children) to compute IYCF indicators. The latter included minimum dietary diversity (MDD), minimum meal frequency (MMF), and minimum acceptable diet (MAD), as well as intake of micronutrient‐rich foods and food groups, specific SSBs, and infant formula. We conducted trend analyses using logistic regression models adjusted for child's age in month, child age squared, governorates, urban/rural residence, mother's educational attainment, and household wealth quintiles. We found that the proportion of consumption of micronutrient‐rich food groups declined significantly between 1990 and 2017, with fewer infants and young children consuming eggs (OR = 0.39, p ≤ 0.001, 2002 reference), meat, poultry, and fish (OR = 0.25, p ≤ 0.001, 2002 reference), dairy (OR = 0.59, p ≤ 0.001, 2002 reference) and Vitamin A‐rich fruits and vegetables (OR = 0.66, p ≤ 0.001, 2002 reference). Conversely, there was increased use of BMSs and sugar‐sweetened juices that paralleled a decline in the share of infants and young children meeting appropriate CF practices and consuming micronutrient‐rich foods and food groups. By 2017, children aged 6–23 months were significantly less likely to meet MDD, MMF, and subsequently MAD; the odds of consuming BMSs were almost three times the reference (OR = 3.8, p ≤ 0.001, 1990 reference), as were the odds of consuming sugar sweetened juices (OR = 3.63, p ≤ 0.001, 1990 reference). Food insecurity and undernutrition are low in Jordan; however, overweight and obesity rates are increasing concurrently as are micronutrient deficiencies. This highlights the need for policymakers to address factors at individual and household levels (behaviours and practices) as well as environmental issues (increasing access to unhealthy and ultraprocessed foods).
Is it possible to generate an additional pleasant and pain‐relieving muscle stimulation when using a low‐frequency spinal cord stimulation (SCS) for the treatment of lower back pain? Pilot study: A new technique: “MuscleSCS”
Authors: Morgalla Matthias Hubert , Marquetand Justus , Staber Franziska Katharina 
Published: December 2023

AbstractObjectiveThe combined use of spinal cord stimulation (SCS) and muscle stimulation, in the treatment of chronic pain, using the same probe, could improve the clinical results. However, this technique has not been established as yet. It was our hypothesis that it is possible to generate muscle stimulation by using low frequencies with SCS electrodes and use it to additionally treat chronic back pain.MethodsWe generated muscle stimulation in patients with previously implanted SCS electrodes, for the treatment of lower back pain, by using low frequencies (2, 4, 6, and 8 Hz) and different contact combinations of the electrodes. The results were evaluated by using visual inspection (videos), haptic control, surface electromyography (EMG), and sonographic recordings.ResultsThis pilot study (17 patients, seven females, age 36–87 years, 11 percutaneous paddle leads, and 6 octrodes) was performed at the Neurosurgical Department of the University of Tuebingen. The most preferred frequencies were 6 Hz (45.5% of percutaneous paddle leads) and 8 Hz (50% of octrodes) at contacts 3&4 or 5&6. The preference of frequencies differed significantly among genders (p = 0.023). Simultaneous EMG and ultrasonic recordings demonstrated the generation of muscle potentials and the stimulation of deeper muscle groups.ConclusionIn this study, it has been shown that with low‐frequency SCS stimulation, pleasant and pain‐relieving muscle contractions of the lower and upper back can also be generated. This combined method has been coined by us as “MuscleSCS” technique. Clinical trials are necessary to establish the value of this combined technique and its subtypes.
Pregnancy and birth rate outcomes in alpacas (Vicugna pacos) inseminated with frozen semen using two commercial extenders
Authors: Huamani M. Contreras , Olaguivel Flores C. A. , Palomino C. Y. Guillen , Carretero M. I. , Fumuso F. G. , Arcce I. M. Laines 
Published: December 2023

AbstractThe aim of this study was to evaluate alpaca pregnancy outcomes and birth rates of females inseminated with frozen semen using two commercial extenders. A total of 18 ejaculates from 8 adult alpaca males were obtained with artificial vagina, and macroscopic and microscopic semen characteristics were assessed. Afterwards, samples were divided into two aliquots, diluted with Biladyl® B or AndroMed®, and cooled for 2 h at 5°C. At that moment, sperm motility was evaluated, and samples were frozen through a gradual descent of temperature using a liquid nitrogen tank. To analyse frozen sperm quality, samples were thawed at 38°C for 30 s. Even though a significant decrease in sperm motility and viability was detected when thawed (p < .05), no superiority was found between the two commercial extenders (Biladyl® B vs. AndroMed®). A total of 36 alpaca females were artificially inseminated (AI) between 30 and 34 h post‐injection of a GnRH analogue, administered when a growing dominant follicle was detected through transrectal palpation and ultrasonography. Obtained pregnancy rates were similar between Biladyl® B (33.3%, 6/18) and AndroMed® (22.2%, 4/18). No significant differences were detected in birth rates between the two tested extenders, obtaining 4 and 3 births for Biladyl® and AndroMed®, respectively. In conclusion, alpaca pregnancies and alive offspring can be obtained through AI with frozen semen at similar efficiency rates using commercial diluents, Biladyl® B or AndroMed®.