bluuebunny/crossref_metadata_2025_split huggingface dataset:
Lipid peroxidation products and superoxide dismutase activity in women depending on the phosphatidylethanol level in the first trimester of pregnancy
Authors: Novikova E. A. , Semenova N. V. , Karacheva A. N. , Nikitina O. A. , Marianian A. Yu. , Bairova T. A. , Belskikh A. V. , Belyaeva E. V. , Sambyalova A. Yu. , Ershova O. A. , Kolesnikova L. I. 
Published: January 2025

Background. Even small amounts of alcohol have an extremely negative effect on the fetus, especially in the early stages of gestation. It is known that ethanol promotes the formation of free radicals, but there is no data on the nature of the oxidative stress development in pregnant women depending on its blood level.The aim. To assess the level lipid peroxidation products and superoxide dismutase activity in the first trimester of pregnancy for women, who consumed alcoholic bevera ges, depending on the phosphatidylethanol (PEth) level in the blood.Materials and methods. The study included 165 women in the first trimester of pregnancy aged 18 to 40 years. To identify the fact and amount of alcohol consumption, the direct biomarker of alcohol 16:0/18:1PEth in blood plasma was performed using high-performance liquid chromatography with tandem mass spectrometry. Depending on the concentration of PEth, groups of women consuming different doses of alcohol were identified: group 1 – PEth concentration < 8 ng/ml (non-drinkers; n = 63); group 2 – PEth concentration from 8 to 45 ng/ml (drinkers of less than 1 dose; n = 66); group 3 – PEth concentration ≥ 45 ng/ml (drinkers of more than 1 dose; n = 36). The content of lipid peroxidation products and superoxide dismutase activity was determined by spectrophotometric methods.Results. It was found that lipid peroxidation intermediates level in the groups of women who consume alcohol, regardless of PEth 16:0/18:1 level in blood plasma, was significantly higher compared with the control (p < 0.05). The superoxide dismutase activity was higher in the group of pregnant women who consumed less than 1 dose of alcohol compared with the control (p < 0.05) and the group who consumed one or more doses of alcohol (p < 0.05).Conclusion. The obtained results indicate the activation of lipid peroxidation processes in the first trimester of pregnancy regardless of the dose of alcohol-containing products consumed.
Legg – Calve – Perthes disease: Modification of the experimental design and its morphological criteria
Authors: Sertakova A. V. , Ulyanov V. Yu. , Sadchikov D. D. 
Published: January 2025

Legg – Calve – Perthes disease (LCPD) is the most common femoral head osteonecrosis in children. Until now, the knowledge of etiology, pathogenesis and clinical signs is partial and does not provide a coherent view of the disease. Despite modern advances in understanding and diagnosing of the disease, surgical interventions and stress release remain the standard treatment methods. Now there is a need to develop both new strategies for studying the pathogenesis of the disease and choosing methods of its treatment.The aim. Reproduction and development of morphological criteria for the early stage of Legg – Calve – Perthes disease (stages 1–2 by the modified Waldenström classification system).Materials and methods. The research involved 6 young gray giant rabbits (Flandres) aged 3–4 months. The early stages of LCPD were simulated by the pathophysiological model of Kuzhelivsky I.I. et al. (2016) with paraarticular adrenaline injections along with physical activity. We modified the physical activity regime for the subjects by daily free range for 1.5–3 hours.Results. The experiment confirmed the validity of the modified simulation and designed its morphological criteria. The osteochondropathy process was verified histologically, we also revealed the classic signs of damage to subchondral bone and hyaline cartilage as well as abnormal vascularization of cartilage sites and pathological neoangiogenesis.Conclusion. The technique of non-traumatic osteonecrosis simulation in young rabbits featured initial results in reproducing the pathological links of osteonecrosis process. The cartilage tissue featured the loss of isogeneity in chondrocytes structure and their column-like arrangement; its delamination and replacement with fibrous tissue, including fibroblast-like cells and collagen fibers; cartilage neovascularization and persistent mixed hyperemia. In the bone marrow, only the activation of the red blood cell line was noted. The bone tissue featured the abnormality of osteon structure with a mosaic arrangement of trabeculae as well as lacunar resorption, and osteoblast degeneration.
Predicting the risk of developing drug-induced liver injury during remdesivir therapy in COVID-19 patients using machine learning
Authors: Shevchuk Yu. V. , Shamigulov I. I. , Sychev I. V. , Kryukov A. V. , Temirbulatov I. I. , Mirzaev K. B. , Denisenko N. P. , Abdullaev Sh. P. , Tuchkova S. N. , Vechorko V. I. , Averkov O. V. , Sychev D. A. 
Published: January 2025

Background. The antiviral drug Remdesivir has been widely used for etiotropic treatment of COVID-19. The incidence of adverse reactions during Remdesivir therapy reaches 66.2 %, the most common one being an increase in hepatic transaminases.The aim. To develop a machine learning model for predicting the risk of drug-induced liver damage in patients with COVID-19 when prescribing Remdesivir therapy.Materials and methods. This prospective open-label observational study was conducted between November 2021 and February 2022, including 154 patients receiving Remdesivir therapy. Patients were divided into two groups: group 1 (n = 45), in which patients developed signs of liver damage during Remdesivir therapy; group 2 (n = 109) – patients without this adverse reaction. All patients underwent pharmacogenetic study and retrospective analysis of medical histories, database with the results of the conducted studies was formed, basing on which machine learning models for predicting the risk of drug-induced liver damage were trained.Results. The main prognostic factors included body mass index (relevance – 12.03 %) and carriage of AG genotype at polymorphic marker rs776746 of CYP3A5 gene (relevance – 10.04 %). Subsequently, for all obtained factors and based on Сategorical boosting a model for predicting the development of drug-induced liver damage with 57.8 % sensitivity and specificity of 80.7 % was developed.Conclusions. A risk model for the development of drug-induced liver damage during remdesivir therapy was built using machine learning. Body mass index and carriage of AG genotype at polymorphic marker rs776746 of CYP3A5 gene turned out to be key markers. To improve the accuracy of the model, an increase in the proportion of patients with adverse reactions in the training sample is required. Further studies will improve the quality of the model and integrate it into clinical practice.
TAKING INTO ACCOUNT THE JOINT OPERATION OF PRECAST CONCRETE COATING DISKS AS PART OF SPAN BENDING METAL STRUCTURES
Authors: Dmytrenko Yevhen , Andrievska Maria , Yakovenko Ihor 
Published: January 2025

Traditional methods of beam’s structures calculation for industrial buildings' coatings provide their consideration separately from the frame structures, in particular, reinforced concrete slabs, without taking into account their joint work, which leads to a significant safety margin of structures. Today, there is a significant number of industrial buildings and structures that require strengthening and reconstruction in Ukraine. In this regard, studies of the actual load-bearing capacity of single-storey industrial building frames are particular importance, both during reconstruction and new construction. Their results will significantly reduce costs and allow for more rational design of structures. At the same time, one of the most relevant areas is the study of the joint operation of metal load-bearing structures with precast concrete structures of hard discs coatings and slabs in their calculation. Moreover, in the Ukrainian national design standards, as well as in the educational and methodological literature, the calculation methods for taking into account the joint operation of such structures are not fully covered.
The purpose of study is to assess the reduction of metal consumption for steel truss structure in its bending calculation, taking into account the joint operation with a rigid precast concrete slab disc.
Method. As part of the study, It was calculated a flat roof truss from the paired corners of an one-storey industrial building according to the traditional design scheme – without taking into account the joint operation with the slab disc and taking into account the joint operation with the slabs by means of numerical modelling as part of a roof block using the finite element method. The modelling of the pavement fragment (block) was performed in LIRA FEM 2022 software.
The main results. It is performed a comparative analysis of the internal forces in steel truss elements and the total mass of the truss based on the selected cross-sections of its elements by two design models. The practical significance of the obtained results is to determine the economic effect by reducing the material consumption and the degree of unloading of steel trusses as part of the roofing block of a one-storey industrial building, taking into account their joint operation with hard discs of precast concrete slabs.
Combined intrathecal baclofen pump revision to the cervical level and lumbosacral ventral-dorsal rhizotomy for severe medically refractory hypertonia: illustrative cases
Authors: Abdelmageed Sunny , Bae Gloria H. , Mossner James M. , Trierweiler Robin , Keen Mary E. , Katholi Benjamin , Raskin Jeffrey S. 
Published: January 2025

BACKGROUND
Medically refractory hypertonia (MRH) within the pediatric population causes severe disability and is difficult to treat. Neurosurgery for mixed MRH includes intrathecal baclofen (ITB) and lumbosacral ventral-dorsal rhizotomy (VDR). Surgical efficacy limitations can be mitigated by combining the two into a multimodal strategy. The authors examined outcomes following a multimodal neurosurgical strategy combining intraspinal ITB catheter revision to the cervical level and lumbosacral VDR.

OBSERVATIONS
Two patients with severe MRH resistant to ITB delivered through a thoracic catheter tip were identified: 1) a 16-year-old boy with quadriplegic mixed hypertonia and 2) a 17-year-old girl with secondary dystonia. The patient in case 1 experienced improvement in his Barry-Albright Dystonia Scale (BADS) score from 29 to 17 and lower-extremity modified Ashworth Scale score from 4 to 0 at 18 months postoperatively; the patient in case 2 experienced a decrease in her BADS score from 30 to 13 at 6 months postoperatively. Significant improvement in caregiving provisions, including patient positioning and transfers, was reported.

LESSONS
The authors highlight favorable outcomes using multimodal surgery in pediatric patients. Multimodal therapy is surgically feasible and better addresses MRH, particularly in patients in whom ITB monotherapy and polypharmacy have failed. Future studies with larger patient volumes are necessary to optimize indications and make more definitive outcome conclusions.
https://thejns.org/doi/10.3171/CASE24599
Exploring Challenges and Solutions in Tourism Village Management in the Manggarai Region, NTT
Authors: Ndiung Sabina , Sutam Inosensius , Menggo Sebastianus 
Published: January 2025

Objects in tourism villages are valuable resources which government villages can employ to improve the prosperity of rural communities throughout Indonesia. Using these assets is an essential component of managing a tourist destination. The level of service provided to tourists is determined by how successfully the management performs their responsibilities. This Community Service explores the challenges that arise when developing eight tourist villages in the Manggarai district of West Flores, Indonesia. This Community Service is expected to address numerous problems in the management of eight tourist villages by involving 93 tourism stakeholders. This Community Service activity was carried out in eight villages during two months (November – December 2023). Data collection in this service through questionnaires, observations and interviews, then data was analyzed descriptive-quantitatively. The results show that eight villages have a number of obstacles, such as unavailability of tourist information centers in tourist villages (86%), English language communication (82.8%), rabid animals or other infectious agents at tourist locations (82.8%), infrastructure (78 .5%), environmental sustainability (77.4%), followed by hygiene and health issues (71%). The West Flores tourism community has a lot of potential, but it will only come true if it has been prepared for and the right steps are taken immediately.
Optimalisasi Pemanfaatan Lahan Pasang Surut Untuk Budidaya Cabai Rawit Bonita IPB di Desa Banyu Urip, Kecamatan Tanjung Lago, Banyuasin
Authors: Bastomi Karlin Agustina , Yursida  , Pandriadi  , Mareza Evriani , Martadela Tedy , Mutia Fifi 
Published: January 2025

Cabai rawit merupakan salah satu jenis cabai yang banyak dikonsumsi. Beragamnya jenis masakan nusantara yang menggunakan cabai rawit sebagai bahan baku membuat kebutuhan cabai rawit pada masyarakat Indonesia semakin besar. Upaya peningkatan produksi cabai rawit antaralain dengan menggunakan varietas unggul dan melalui usaha ekstensifikasi dengan memanfaatkan lahan sub optimal. Salah satu cabai rawit unggul hasil penelitian tim PKM Universitas IBA bersama konsorsium cabai IPB adalah cabai rawit Bonita IPB yang telah mendapatkan legalisasi pelepasan varietas dari Kementerian Pertanian RI dengan nomor Surat Keputusan 343/Kpts/SR.130/D/IV/2021 tentang Pemberian Tanda Daftar Varietas Tanaman Hortikultura Cabai Rawit Bonita IPB tanggal 26 April 2021. Cabai rawit ini cocok dikembangkan di lahan pasang surut. Salah satu daerah pasang surut yang berpotensi untuk pengembangan cabai rawit Bonita IPB berlokasi di Desa Banyu Urip Kecamatan Tanjung Lago. Tim penulis berupaya memberikan solusi atas permasalahan produksi dan pemasaran hasil usaha tani melalui peningkatan pengetahuan dan kapasitas serta peningkatan ekonomi masyarakat khususnya pada Kelompok Tani Tani Mukti yang menjadi mitra sasaran . Metode pelaksanaan kegiatan meliputi: 1) survei, observasi serta identifikasi permasalahan mitra, 2) perizinan, pendekatan mitra dan sosialisasi,3) pelatihan, pembimbingan dan pendampingan, 4) penerapan teknologi/pembuatan demo plot dan 5) monitoring dan evaluasi. Hasil kegiatan telah dilakukan pembuatan demo plot di lahan milik Bapak Ponio anggota kelompok tani Tani Mukti berlokasi di Desa Banyu Urip RT.04 Dusun 1 Jembatan 4. Saat ini tanaman telah berumur 3 bulan dan mulai berbuah. Para petani telah diberikan pelatihan mengenai budidaya tanaman cabai rawit Bonita IPB, hama penyakit tanaman cabai serta teknik pengendaliannya dan digital marketing produk usaha tani.
Konseling Pra-Nikah : Pentingnya Kesiapan Psikologis Sebelum Memasuki Kehidupan Pernikahan
Authors: Amalia Juniarly  , Tarigan Angeline Hosana Zefany , Anggraini Dewi , Rachmawati  
Published: January 2025

Konseling pra-nikah adalah layanan bimbingan dan konsultasi yang diberikan kepada pasangan yang berencana untuk menikah. Tujuan utamanya adalah membantu pasangan memahami dan mempersiapkan diri untuk berbagai aspek pernikahan, sehingga mereka lebih siap menghadapi tantangan yang mungkin muncul dalam kehidupan berumah tangga. Dalam konseling ini, pasangan diajak untuk membahas topik-topik penting seperti komunikasi, keuangan, peran dan tanggung jawab, nilai-nilai dan harapan, cara mengelola konflik, hingga perencanaan keluarga. Kegiatan ini dilaksanakan dengan metode asesmen, konseling, dan latihan kasus. Berdasarkan hasil konseling diketahui bahwa secara kesuluruhan, baik MRR maupun VAI merasa sangat puas (skor 25 untuk keduanya). Begitupun dengan AY (skor 24) dan DF (skor 23), mereka juga sangat puas dengan semua aspek yang dimiliki dalam hubungan mereka, yaitu kepuasan umum dalam hubungan; komunikasi dalam hubungan; keintiman dan kedekatan emosional; dukungan dan kerjasama; penyelesaian konflik; keseimbangan kehidupan pribadi dan hubungan; serta kepuasan secara kesuluruhan atas hubungan yang dimiliki saat ini. Untuk memperkuat hubungan, AY dan DF memiliki kesamaan langkah untuk meningkatkan komunikasi dan menyusun rencana keuangan bersama. Sementara MRR dan VAI memiliki kesamaan langkah untuk meningkatkan komunikasi dan mengatur waktu untuk aktivitas pribadi.
LEGAL PROTECTION OF VICTIMS OF COMMERCIAL SEXUAL EXPLOITATION OF CHILDREN THROUGH SOCIAL MEDIA
Authors: Tamba Samuel , Hafrida  , Herry Liyus  
Published: January 2025

The crime of Commercial Sexual Exploitation of Children (ESKA) is increasingly rife with the existence of social media as a means of transaction and promotion of children who are victims. However, there is currently a vacuum in regulations that specifically regulate legal protection of the rights of children victims of these crimes. This study aims to describe the applicable rules in protecting children victims of CSEC through social media and how legal policies will be in the future in handling these crimes. The research method used is normative juridical research. From the results of the study, it was found that there is more than one legal regulation that is currently used to protect child victims of commercial sexual exploitation crimes through social media, namely the Child Protection Law, the Pornography Law, the Electronic Information and Transactions Law and the Sexual Violence Criminal Law. Some of the obstacles in protecting CSEC victims include: 1) legal substance factors (overlapping laws and regulations that specifically regulate CSEC crimes through social media), 2) legal structure factors (there is no legal umbrella for investigators and public prosecutors to be able to quickly break the chain of dissemination of cases of commercial sexual exploitation of children on social media; 3) legal cultural factors (public awareness, lack of parental monitoring, and lack of sexual education in children). The suggestions for future legal policies include: 1) Revising the Child Protection Law and the ITE Law; 2) strengthen the authority of the Prosecutor's Office and the Police as investigators and public prosecutors to remove social media content containing commercial sexual exploitation of children from the investigation and prosecution stages; 3) Create a child-friendly complaint and reporting center that is easily accessible to child victims of sexual exploitation crimes.
Keywords: commercial sexual exploitation of children; social media; legal protection.
Review of Sailing Tour Package at PT. Manumadi Wisata Labuan Bajo
Authors: Nabila Azzahra Hakim  , Rahmawati Rahmawati , Hanafi Hamsu 
Published: January 2025

This study aims: (1) To find out how the process off designing a sailing tour package at PT. Manumadi Wisata Labuan Bajo and. (2) To find out the pricing process for sailing tour packages at PT. Manumadi Wisata Labuan Bajo Tourism.. Data collection from this study was taken by the following techniques: interviews and documentation and data analysis was carried out by qualitative descriptive and drawing conclusions. In this case the author reviews the sailing tour package at PT. Manumadi Wisata Labuan Bajo, because the author sees the potential of Labuan Bajo as a one of superior tourist destination in Indonesia which has recently become a popular tourist spot that has a selling point for making tour packages so that the author was interesting in raising the title. “Review of Sailing Tour Packages at PT. Labuan Bajo Tourism Manumadi”. A tour package review, is a review of the making a tour package from the process of designing a tour package to the fixed price of a tour package to a tour package that is ready to be marketed. however, in the manufacturing process of course there are obstacles and defiance before it becomes a ready to sell tour package, so it is necessary to innovate by combining tourist attraction that is a sailing tour and a tourist attraction on land. Then it is necessary to lower the mark up a little and negotiate with various parties so that it becomes an inexpensive or affordable tour package and becomes a ready to sell tour package that is competitive for other agents.
Evaluation of the efficacy of a novel lumbar exoskeleton with multiple interventions for patients with lumbar disc herniation: a multicenter randomized controlled trial of non-inferiority
Authors: Huang Xiaonan , Huang Lele , Shi Lei , Xu Lifan , Cao Chengbing , Wu Heng , Cao Min , Lv Can , Shi Ping , Zhang Guohui , Fang Fanfu 
Published: January 2025

BackgroundLumbar disc herniation (LDH) occurs when the nucleus pulposus or annulus fibrosus protrudes into the intervertebral space, potentially compressing nerve roots and causing symptoms such as sciatica, restricted mobility, and lower extremity weakness. The development of portable lumbar exoskeleton devices offers a new approach, combining traction, range of motion (ROM) exercises, and resistance training in a single system, potentially reducing treatment complexity and enhancing LDH patient outcomes.ObjectiveThis study aims to evaluate the efficacy and safety of a novel lumbar exoskeleton device compared to traditional traction methods combined with rehabilitation therapy for patients with LDH.MethodsA multicenter, non-inferiority randomized controlled trial was conducted with 118 participants diagnosed with LDH. Participants were randomly assigned to the Exoskeleton Group or the Traction Group. The Exoskeleton Group used the novel device for traction, ROM, and resistance training, while the Traction Group underwent traditional traction and rehabilitation therapy. Outcomes included efficacy rate after 10 treatments, Visual Analogue Scale (VAS), Oswestry Disability Index (ODI), and lumbar ROM—were assessed at 3, 6, and 10 treatments.ResultsA total of 118 eligible participants were recruited. After 10 treatments, both groups showed significant improvements in VAS scores, ODI, and lumbar ROM compared to baseline (P &lt; 0.001). However, there was no significant difference in the overall efficacy rate between the two groups (P = 0.748).ConclusionThe novel lumbar exoskeleton device demonstrates comparable efficacy and safety to traditional traction therapy combined with rehabilitation, offering a promising alternative for the conservative treatment of LDH.