bluuebunny/crossref_metadata_2025_split huggingface dataset:
Amended FRW universe: thermodynamics and heat engine
Authors: Bhadra Jhumpa , Debnath Ujjal , Pradhan Anirudh 
Published: February 2024

AbstractThermodynamics of non-flat Amended Friedmann–Robertson–Walker (AFRW) universe with cosmological constant as thermodynamic pressure is studied. The unified first law of thermodynamics, the Clausius relation and the gravity equations yield entropy on the dynamic apparent horizon. Temperature, volume, pressure, enthalpy, Gibb’s free energy and Helmholtz’s free energies, and specific heat capacity with constant pressure of the universe are calculated in terms of surface area of dynamic apparent horizon. The study shows a non-negative Joule–Thomson coefficient, indicating the cooling nature of the AFRW universe. Inversion pressure and inversion temperature are expressed in terms of the surface area of the apparent horizon. Finally, the thermodynamical AFRW universe is considered as a heat engine. Work done for the Carnot engine is derived with maximum efficiency, and a new engine is also considered for which the work done, and its efficiency are calculated for AFRW universe.
Lingual Denervation Improves the Efficacy of Anti-PD-1 Immunotherapy in Oral Squamous Cell Carcinomas by Downregulating TGFβ Signaling
Authors: Tao Zhuo-Ying , Wang Leilei , Zhu Wang-Yong , Zhang Gao , Su Yu-Xiong 
Published: February 2024

Abstract

Purpose:
Intratumoral nerve infiltration relates to tumor progression and poor survival in oral squamous cell carcinoma (OSCC). How neural involvement regulates antitumor immunity has not been well characterized. This study aims to investigate molecular mechanisms of regulating tumor aggressiveness and impairing antitumor immunity by nerve-derived factors.

Experimental Design:
We performed the surgical lingual denervation in an immunocompetent mouse OSCC model to investigate its effect on tumor growth and the efficacy of anti-PD-1 immunotherapy. A trigeminal ganglion neuron and OSCC cell coculture system was established to investigate the proliferation, migration, and invasion of tumor cells and the PD-L1 expression. Both the neuron-tumor cell coculture in vitro model and the OSCC animal model were explored.

Results:
Lingual denervation slowed down tumor growth and improved the efficacy of anti-PD-1 treatment in the OSCC model. Coculturing with neurons not only enhanced the proliferation, migration, and invasion but also upregulated TGFβ-SMAD2 signaling and PD-L1 expression of tumor cells. Treatment with the TGFβ signaling inhibitor galunisertib reversed nerve-derived tumor aggressiveness and downregulated PD-L1 on tumor cells. Similarly, lingual denervation in vivo decreased TGFβ and PD-L1 expression and increased CD8+ T-cell infiltration and the expression of IFNγ and TNFα within tumor.

Conclusions:
Neural involvement enhanced tumor aggressiveness through upregulating TGFβ signaling and PD-L1 expression in OSCC, while denervation of OSCC inhibited tumor growth, downregulated TGFβ signaling, enhanced activities of CD8+ T cells, and improved the efficacy of anti-PD-1 immunotherapy. This study will encourage further research focusing on denervation as a potential adjuvant therapeutic approach in OSCC.

Significance:
This study revealed the specific mechanisms for nerve-derived cancer progression and impaired antitumor immunity in OSCC, providing a novel insight into the cancer-neuron-immune network as well as pointing the way for new strategies targeting nerve-cancer cross-talk as a potential adjuvant therapeutic approach for OSCC.
NIITA KALAGA, LUGAL URI: A memória de Gilgamesh como mecanismo para a construção da ideia de rei-deus no período de Ur-III
Authors: Guimarães Ana Clara Reis de 
Published: February 2024

No presente artigo, as referências à Primeira Dinastia de Uruk, nos textos literários escritos durante o reinado de Shulgi de Ur III (2.094 – 2.047 a.E. C.), são consideradas como conceito de memória cultural. Por meio dessa análise, a tradição acerca destes reis míticos influenciou o processo de transformação de Shulgi em deus, sendo esse processo entendido como estratégia política frente à crise suscitada pela morte precoce de seu antecessor. Dessa forma, o artigo visa discorrer sobre a recuperação da memória de um passado sumério idealizado como ferramenta para a construção de uma figura carismática num contexto de busca por legitimação do poder territorial.
Exercise Inhibits Doxorubicin-Induced Cardiotoxicity via Regulating B Cells
Authors: Wang Jing , Liu Shuqin , Meng Xinxiu , Zhao Xuan , Wang Tianhui , Lei Zhiyong , Lehmann H. Immo , Li Guoping , Alcaide Pilar , Bei Yihua , Xiao Junjie 
Published: February 2024

BACKGROUND:
Doxorubicin is an effective chemotherapeutic agent, but its use is limited by acute and chronic cardiotoxicity. Exercise training has been shown to protect against doxorubicin-induced cardiotoxicity, but the involvement of immune cells remains unclear. This study aimed to investigate the role of exercise-derived B cells in protecting against doxorubicin-induced cardiotoxicity and to further determine whether B cell activation and antibody secretion play a role in this protection.

METHODS:

Mice that were administered with doxorubicin (5 mg/kg per week, 20 mg/kg cumulative dose) received treadmill running exercise. The adoptive transfer of exercise-derived splenic B cells to μMT
−/−
(B cell–deficient) mice was performed to elucidate the mechanism of B cell regulation that mediated the effect of exercise.

RESULTS:

Doxorubicin-administered mice that had undergone exercise training showed improved cardiac function, and low levels of cardiac apoptosis, atrophy, and fibrosis, and had reduced cardiac antibody deposition and proinflammatory responses. Similarly, B cell pharmacological and genetic depletion alleviated doxorubicin-induced cardiotoxicity, which phenocopied the protection of exercise. In vitro performed coculture experiments confirmed that exercise-derived B cells reduced cardiomyocyte apoptosis and fibroblast activation compared with control B cells. Importantly, the protective effect of exercise on B cells was confirmed by the adoptive transfer of splenic B cells from exercised donor mice to μMT
−/−
recipient mice. However, blockage of Fc gamma receptor IIB function using B cell transplants from exercised Fc gamma receptor IIB
−/−
mice abolished the protection of exercise-derived B cells against doxorubicin-induced cardiotoxicity. Mechanistically, we found that Fc gamma receptor IIB, an important B cell inhibitory receptor, responded to exercise and increased B cell activation threshold, which participated in exercise-induced protection against doxorubicin-induced cardiotoxicity.

CONCLUSIONS:
Our results demonstrate that exercise training protects against doxorubicin-induced cardiotoxicity by upregulating Fc gamma receptor IIB expression in B cells, which plays an important anti-inflammatory role and participates in the protective effect of exercise against doxorubicin-induced cardiotoxicity.
The Liturgical Targum to Pesach
Authors: Verrijssen Jeroen 
Published: February 2024

Abstract
This paper presents the Targum text to Exod. 13:17–15:26 (the reading for the seventh day of Pesach) in the form that it is preserved in mahzorim (or festival prayerbooks). These liturgical manuscripts are witnesses to a textual tradition, hereafter named the “Liturgical Targum” (LTg), that is genealogically related to the broader Palestinian Targum tradition (PalTg), sharing a common source with other PalTg witnesses such as Targum Neofiti and the Fragment Targums. As reading traditions changed over time, and the role of Targum diminished within the synagogue, the text of LTg evolved: units ranging from individual words to entire verses of PalTg were removed or replaced with units of Targum Onqelos (TgOnq). Other PalTg texts show signs of this process of “Onqelosization,” including the text of Fragment Targum P (FragTgP), an enigmatic manuscript that contains the festival reading for the seventh day of Pesach (among other things). This paper will argue two main points: 1. the units of Targum that are shared between LTg and other members of the PalTg tradition show influence by TgOnq (i.e., “Onqelosization”); 2. FragTgP contains part of a text that is directly related to LTg and also contains Onqelosization.
Unconditionally conditional
Authors: Duffley Patrick , Larrivée Pierre 
Published: February 2024

Abstract
The purpose of this study is to assess from a corpus-based discourse-pragmatic perspective certain claims made in the literature concerning English wh- concessive conditional constructions (e.g. Whoever/No matter who comes to the party, it will be fun), namely that these utterance-types correlate with interrogative semantics, scalarity and potential modality. By means of an extensive investigation of corpus data these claims are shown to be largely unsupported by attested usage. Based on Dancygier and Sweetser’s classification of conditional constructions, it is found that potential modality is paradigmatic only of content-level concessive conditionals, and not of the epistemic, speech-act or metalinguistic varieties. Contrary to claims in the literature, scalarity is demonstrated to not be typical of wh- concessive conditionals. The lack of scalarity in most wh- concessive conditionals is argued to cast into doubt the category label “concessive conditional” applied to these constructions in a substantial part of the literature and to favour an alternative designation such as “irrelevance conditional.” The empirical data further reveals that wh- concessive conditionals practically never involve pure ignorance, and this is argued to be problematic on the discourse-pragmatic level for the claim that they have interrogative semantics.
Expressive commitments
Authors: Villalba Xavier 
Published: February 2024

Abstract
Pragmatics has made a Copernican shift from Gricean intentional approaches to normative approaches based in commitments. This has been good news for assertions, and questions of several stripes, but we still don’t know whether the commitment approach can be extended to expressive speech acts in general, and exclamations in particular. In this article, I will show that an approach to exclamations based on commitments at different levels of meaning, namely, the descriptive and expressive level, can be devised and it can offer interesting answers to old issues, like the contribution of exclamations to discourse, or their at-issue status, while raising new theoretical and empirical questions on lying and deceiving and commitment strength.
Prototype-based pragmatics of confessing
Authors: Yamanaka Nobuhiko 
Published: February 2024

Abstract
This paper discusses a subtype of the speech act of confessing, namely, telling something which the speaker assumes to be unknown to the hearer and damaging to him/herself. Based on Coleman and Kay (1981), a prototype of that subtype is hypothesised and cases lacking in any of its elements are illustrated. Further, the prototypical scenario proposed in Lakoff (1987) is applied to the speech act of confessing to describe all the processes and effects of confessing. The data consist of confessional scenes played by characters in literary works either written in or translated into English.
A Climatology of Intensity Change and Translation Speed of Landfalling North American Tropical Cyclones between 1971 and 2020
Authors: Grondin Nicholas S. , Ellis Kelsey N. 
Published: February 2024

Abstract
In this study, we investigated the translation speed and intensity change characteristics for landfalling North American tropical cyclones (TCs) from 1971 to 2020. We calculated three variables—intensity change, mean translation speed, and translation speed change—prior to each TC landfall and investigated the climatology of these variables for seven coastal segments. We found that lower-latitude segments generally had greater positive intensity changes prior to landfall, and higher-latitude segments had greater translation speeds. Longitude primarily influenced translation speed changes, with landfalling TCs along the Atlantic coast of the United States notably accelerating prior to landfall. Temporal trends in each of these variables were inconsistent geographically, but most segments showed an increase in positive intensity changes over time, demonstrating the increasing likelihood of intensifying TCs before landfall in recent years. We defined extreme intensification and extreme weakening as the 90th and 10th percentile of all landfalling TC intensity changes, respectively. We found that extreme intensification and weakening have been increasing and decreasing in frequency, respectively. Results from this study can be used in a variety of future applications, including in operational forecasting and model production, and provide a baseline for climate attribution studies investigating extreme intensity change events.

Significance Statement
Landfalling tropical cyclones pose significant hazards to life and property in coastal regions across North America. This study develops a comprehensive climatology of intensity change and translation speed of tropical cyclones during the final 36 h prior to landfall. We found that incidences of extreme intensification and weakening of landfalling North American tropical cyclones have increased and decreased, respectively, since 1971. We also identify lower-latitude coastal segments tend to average faster translation speeds that higher-latitude segments, while segments on the east coast of the United States tended to average a greater acceleration. These results show the importance of looking at tropical cyclone characteristics regionally and provide a useful baseline to assess how tropical cyclone risk is changing in a warming climate.
The Relationship between Convectively Coupled Waves and the East Pacific ITCZ
Authors: Fahrin Fouzia , Gonzalez Alex O. , Chrisler Brett , Stachnik Justin P. 
Published: February 2024

Abstract
Longstanding climate model biases in tropical precipitation exist over the east Pacific (EP) Ocean, especially during boreal winter and spring when models have excessive Southern Hemisphere (SH) precipitation near the intertropical convergence zone (ITCZ). In this study, we document the impact of convectively coupled waves (CCWs) on EP precipitation and the ITCZ using observations and reanalyses. We focus on the months when SH precipitation peaks in observations: February–April (FMA). CCWs explain 93% of total precipitation variance in the SH, nearly double the percent (48%) of the NH during FMA. However, we note that these percentages are inflated as they inevitably include the background variance. We further investigate the three leading high-frequency wave bands: mixed Rossby–gravity waves and tropical depression–type disturbances (MRG–TD type), Kelvin waves, and n = 0 eastward inertia–gravity waves (IG0). Compared to their warm pool counterparts, these three CCWs have a more zonally elongated and meridionally narrower precipitation structure with circulations that resemble past observational studies and/or shallow water theory. We quantify the contribution of all CCWs to four different daily ITCZ “states”: Northern Hemisphere (NH) (nITCZ), SH (sITCZ), double (dITCZ), and equatorial (eITCZ) using a new precipitation-based ITCZ-state algorithm. We find that the percent of total precipitation variance explained by each of the CCWs is heightened for sITCZs and eITCZs and diminished for nITCZs. Last, we find that nITCZs are most prevalent weeks after strong CCW activity happens in the NH, whereas CCWs and sITCZs peak simultaneously in the SH.

Significance Statement
Convectively coupled atmospheric waves (CCWs) are a critical feature of tropical weather and are an important source of precipitation near the region of highest precipitation on Earth called the intertropical convergence zone (ITCZ). Given three decades of climate model biases in CCWs and ITCZ precipitation over the east Pacific (EP) Ocean during spring, few studies have examined the relationship between CCWs and the springtime EP ITCZ. We explored the CCWs and EP ITCZ relationship through calculations of the percent of precipitation that comes from CCWs. A significant portion of the tropical precipitation is associated with CCWs during spring. CCWs are even more impactful when the ITCZ is in the SH or on the equator, which are both problematic in climate models.
Four-Dimensional Computed Tomography for Parathyroid Adenoma Localization: A Pre-Operative Imaging Protocol
Authors: Bellamkonda Nikhil , Highland Julie , McCrary Hilary C , Slattery Lauren , King Brody , Teames Charles , LeBaron Kaylee , Wiggins Richard H , Abraham Dev , Hunt Jason P 
Published: February 2024

Objective: Primary hyperparathyroidism (PHPT) affects approximately 0.86% of the population, with surgical resection as the treatment of choice. A 4D computed tomography (CT) is a highly effective tool in localizing parathyroid adenomas; however, there is currently no defined role for 4D CT when stratified against ultrasonography (USG) and nuclear medicine Technetium Sestamibi SPECT/CT (SES) imaging. Study Design: Retrospective Study. Setting: University Hospital. Methods: All patients who underwent parathyroidectomy for PHPT between 2014 and 2019 at a single institution were reviewed. Patients who had a 4D CT were included. We compared outcomes of 4D CT as a second line imaging modality to those of USG and SES as first line modalities. An imaging algorithm was proposed based on these findings. Results: There were 84 patients identified who had a 4D CT after unsuccessful first line imaging. A 4D CT localized parathyroid adenoma to the correct quadrant in 64% of cases, and to the correct laterality in 75% of cases. Obese patients had significantly lower rates of adenoma localization with USG (33.4%), compared to non-obese patients (67.5%; P = .006). In determining multigland disease the sensitivity of 4D CT was 86%, while the specificity was 87%. Conclusions: A 4D CT has impressive rates of accurate localization of parathyroid adenomas; however due to the radiation exposure involved, it should remain a second line imaging modality. PHPT patients should first be evaluated with USG, with 4D CT used if this is unsuccessful and patients are greater than 40 years old, have a high BMI, or are having revision surgery.
Model of collaborative information retrieval behavior using information systems among academic researchers of medical sciences
Authors: Gholami Shahrzad , Abadi Saeed Rezaei Sharif , Karbala Aghaee Kamran Masoumeh 
Published: February 2024

Aim The purpose of this study was to analyze the collaborative information retrieval (CIR) behavior among faculty members of research centers based in the University of Medical Sciences to present a structural model. Methodology The type of this experimental study was based on a pretest-posttest with the control group. Data were collected using a questionnaire, and the participants were selected by stratified random sampling. Out of a total of 73 participants, there were 42 people in the intervention group and 31 participants in the control group. Findings The variables of awareness, information sharing, division of labor, and team communication had a significant positive relationship with the team collaboration (p < 0.05), collaboration had effect on the evaluation of retrieved information with a significant positive relationship (p < 0.05). Conclusion Based on the findings, CIR is the set of activities that can include factors such as the ability to share the obtained knowledge, analyze the retrieved information, communicate, and collaborative awareness. The structural model confirmed our findings that developing the interactive and synergies capabilities of research team members to increase collaboration through a network-based structure reduces the loss of stored collective knowledge and also accelerates the process of access to information resources, and required content. Originality This research has carried on as the one of the first studies on collaborative information retrieval behavior with an experimental method in Iran and many others countries. A considerable point in the present study was assessing the nature of CIR behavior from the perspective of human behaviors, which was mentioned as a very important approach in information science. Accordingly, a human behavioral approach to information retrieval was considered and strengthened, regardless of technical aspects. Another strength of this study was the model extracted from our findings which have emphasized specifically CIR as specific and dynamic activities.
Effects of kinesiotaping during early post-operative rehabilitation in individuals who underwent a total knee arthroplasty: A systematic review and meta-analysis of randomized control trials
Authors: Ickert Edmund C , Griswold David , Ross Omar , Dudash Shannon , Duchon Colleen , Learman Ken 
Published: February 2024

Objective To report the treatment effects of early use kinesiotaping on pain, range of motion, mobility, and edema outcomes following total knee arthroplasty. Data Sources Cochrane Central Register of Controlled Trials, PubMED, SPORTDiscus, Biosis Citation Index, and the Cumulative Index to Nursing and Allied Health Literature were searched for potential randomized control trials from inception to 8 January 2024. Review Methods Randomized control trials evaluating the effect of kinesiotaping published in English were included. Reference lists for relevant reviews were searched. Study quality was assessed using the Cochrane Risk of Bias 2 tool. Certainty of evidence was determined using the Grading of Recommendations Assessment, Development, and Evaluation approach. Results Seven articles totaling 534 participants were included for meta-analysis. Kinesiotaping with standard rehabilitation when compared to standard rehabilitation alone had very low certainty of evidence in pain and knee flexion range of motion. Kinesiotaping was favored at post-operative days two to four for pain ( P = 0.03, standard mean difference = −0.77 [−1.45, −0.09]) and range of motion ( P = 0.002, standard mean difference = −0.24 [−0.44, −0.03]). Kinesiotaping was favored at post-operative days six to eight for pain ( P = 0.02, standard mean difference = −0.76 [−1.41, −0.12]) and range of motion ( P = 0.04, standard mean difference = −0.63 [−1.22, −0.04]). Edema and mobility could not be meta-analyzed. Conclusion The use of kinesiotaping early in post-operative rehabilitation could be a useful modality for reducing pain and increasing the range of knee flexion, however, the certainty of evidence is very low.