bluuebunny/crossref_metadata_2025_split huggingface dataset:
M2 macrophages independently promote beige adipogenesis via blocking adipocyte Ets1
Authors: Wu Suyang , Qiu Chen , Ni Jiahao , Guo Wenli , Song Jiyuan , Yang Xingyin , Sun Yulin , Chen Yanjun , Zhu Yunxia , Chang Xiaoai , Sun Peng , Wang Chunxia , Li Kai , Han Xiao 
Published: February 2024

AbstractAdipose tissue macrophages can promote beige adipose thermogenesis by altering local sympathetic activity. Here, we perform sympathectomy in mice and further eradicate subcutaneous adipose macrophages and discover that these macrophages have a direct beige-promoting function that is independent of sympathetic system. We further identify adipocyte Ets1 as a vital mediator in this process. The anti-inflammatory M2 macrophages suppress Ets1 expression in adipocytes, transcriptionally activate mitochondrial biogenesis, as well as suppress mitochondrial clearance, thereby increasing the mitochondrial numbers and promoting the beiging process. Male adipocyte Ets1 knock-in mice are completely cold intolerant, whereas male mice lacking Ets1 in adipocytes show enhanced energy expenditure and are resistant to metabolic disorders caused by high-fat-diet. Our findings elucidate a direct communication between M2 macrophages and adipocytes, and uncover a function for Ets1 in responding to macrophages and negatively governing mitochondrial content and beige adipocyte formation.
JAK-STAT-dependent contact between follicle cells and the oocyte controls Drosophila anterior-posterior polarity and germline development
Authors: Mallart Charlotte , Netter Sophie , Chalvet Fabienne , Claret Sandra , Guichet Antoine , Montagne Jacques , Pret Anne-Marie , Malartre Marianne 
Published: February 2024

AbstractThe number of embryonic primordial germ cells in Drosophila is determined by the quantity of germ plasm, whose assembly starts in the posterior region of the oocyte during oogenesis. Here, we report that extending JAK-STAT activity in the posterior somatic follicular epithelium leads to an excess of primordial germ cells in the future embryo. We show that JAK-STAT signaling is necessary for the differentiation of approximately 20 specialized follicle cells maintaining tight contact with the oocyte. These cells define, in the underlying posterior oocyte cortex, the anchoring of the germ cell determinant oskar mRNA. We reveal that the apical surface of these posterior anchoring cells extends long filopodia penetrating the oocyte. We identify two JAK-STAT targets in these cells that are each sufficient to extend the zone of contact with the oocyte, thereby leading to production of extra primordial germ cells. JAK-STAT signaling thus determines a fixed number of posterior anchoring cells required for anterior-posterior oocyte polarity and for the development of the future germline.
Black phosphorus boosts wet-tissue adhesion of composite patches by enhancing water absorption and mechanical properties
Authors: Zhang Yuanchi , Li Cairong , Guo Along , Yang Yipei , Nie Yangyi , Liao Jiaxin , Liu Ben , Zhou Yanmei , Li Long , Chen Zhitong , Zhang Wei , Qin Ling , Lai Yuxiao 
Published: February 2024

AbstractWet-tissue adhesives have long been attractive materials for realizing complicated biomedical functions. However, the hydration film on wet tissues can generate a boundary, forming hydrogen bonds with the adhesives that weaken adhesive strength. Introducing black phosphorus (BP) is believed to enhance the water absorption capacity of tape-type adhesives and effectively eliminate hydration layers between the tissue and adhesive. This study reports a composite patch integrated with BP nanosheets (CPB) for wet-tissue adhesion. The patch’s improved water absorption and mechanical properties ensure its immediate and robust adhesion to wet tissues. Various bioapplications of CPB are demonstrated, such as rapid hemostasis (within ~1-2 seconds), monitoring of physical-activity and prevention of tumour-recurrence, all validated via in vivo studies. Given the good practicability, histocompatibility and biodegradability of CPB, the proposed patches hold significant promise for a wide range of biomedical applications.
Direct in-situ insights into the asymmetric surface reconstruction of rutile TiO2 (110)
Authors: Yuan Wentao , Chen Bingwei , Han Zhong-Kang , You Ruiyang , Jiang Ying , Qi Rui , Li Guanxing , Wu Hanglong , Ganduglia-Pirovano Maria Veronica , Wang Yong 
Published: February 2024

AbstractThe reconstruction of rutile TiO2 (110) holds significant importance as it profoundly influences the surface chemistry and catalytic properties of this widely used material in various applications, from photocatalysis to solar energy conversion. Here, we directly observe the asymmetric surface reconstruction of rutile TiO2 (110)-(1×2) with atomic-resolution using in situ spherical aberration-corrected scanning transmission electron microscopy. Density functional theory calculations were employed to complement the experimental observations. Our findings highlight the pivotal role played by repulsive electrostatic interaction among the small polarons −formed by excess electrons following the removal of neutral oxygen atoms− and the subsequent surface relaxations induced by these polarons. The emergence and disappearance of these asymmetric structures can be controlled by adjusting the oxygen partial pressure. This research provides a deeper understanding, prediction, and manipulation of the surface reconstructions of rutile TiO2 (110), holding implications for a diverse range of applications and technological advancements involving rutile-based materials.
Distinct switching of chiral transport in the kagome metals KV3Sb5 and CsV3Sb5
Authors: Guo Chunyu , van Delft Maarten R. , Gutierrez-Amigo Martin , Chen Dong , Putzke Carsten , Wagner Glenn , Fischer Mark H. , Neupert Titus , Errea Ion , Vergniory Maia G. , Wiedmann Steffen , Felser Claudia , Moll Philip J. W. 
Published: February 2024

AbstractThe kagome metals AV3Sb5 (A = K, Rb, Cs) present an ideal sandbox to study the interrelation between multiple coexisting correlated phases such as charge order and superconductivity. So far, no consensus on the microscopic nature of these states has been reached as the proposals struggle to explain all their exotic physical properties. Among these, field-switchable electric magneto-chiral anisotropy (eMChA) in CsV3Sb5 provides intriguing evidence for a rewindable electronic chirality, yet the other family members have not been likewise investigated. Here, we present a comparative study of magneto-chiral transport between CsV3Sb5 and KV3Sb5. Despite their similar electronic structure, KV3Sb5 displays negligible eMChA, if any, and with no field switchability. This is in stark contrast to the non-saturating eMChA in CsV3Sb5 even in high fields up to 35 T. In light of their similar band structures, the stark difference in eMChA suggests its origin in the correlated states. Clearly, the V kagome nets alone are not sufficient to describe the physics and the interactions with their environment are crucial in determining the nature of their low-temperature state.
A phase III randomized-controlled study of safety and immunogenicity of DTwP-HepB-IPV-Hib vaccine (HEXASIIL®) in infants
Authors: Sharma Hitt , Parekh Sameer , Pujari Pramod , Shewale Sunil , Desai Shivani , Kawade Anand , Lalwani Sanjay , Ravi M. D. , Kamath Veena , Mahopatra Jagannath , Kulkarni Ganesh , Tayade Deepak , Ramanan Padmasani Venkat , Uttam Kheya Ghosh , Rawal Lalit , Gawande Avinash , Kumar N. Ravi , Tiple Nishikant , Vagha Jayant , Thakkar Pareshkumar , Khandgave Prashant , Deshmukh Bhaskar Jedhe , Agarwal Anurag , Dogar Vikas , Gautam Manish , Jaganathan K. S. , Kumar Rakesh , Sharma Inderjit , Gairola Sunil 
Published: February 2024

AbstractA fully liquid hexavalent containing Diphtheria (D), Tetanus (T) toxoids, whole cell Pertussis (wP), Hepatitis B (Hep B), type 1, 2, 3 of inactivated poliovirus (IPV) and Haemophilus influenzae type b (Hib) conjugate vaccine (DTwP-HepB-IPV-Hib vaccine, HEXASIIL®) was tested for lot-to-lot consistency and non-inferiority against licensed DTwP-HepB-Hib + IPV in an open label, randomized Phase II/III study. In Phase III part, healthy infants received DTwP-HepB-IPV-Hib or DTwP-HepB-Hib + IPV vaccines at 6, 10 and 14 weeks of age. Blood samples were collected prior to the first dose and 28 days, post dose 3. Non inferiority versus DTwP-HepB-Hib + IPV was demonstrated with 95% CIs for the treatment difference for seroprotection/seroconversion rates. For DTwP-HepB-IPV-Hib lots, limits of 95% CI for post-vaccination geometric mean concentration ratios were within equivalence limits (0.5 and 2). Vaccine was well-tolerated and no safety concerns observed.Clinical Trial Registration – CTRI/2019/11/022052
Problem-solving skills are predicted by technical innovations in the wild and brain size in passerines
Authors: Audet Jean-Nicolas , Couture Mélanie , Lefebvre Louis , Jarvis Erich D. 
Published: February 2024

AbstractBehavioural innovations can provide key advantages for animals in the wild, especially when ecological conditions change rapidly and unexpectedly. Innovation rates can be compared across taxa by compiling field reports of novel behaviours. Large-scale analyses have shown that innovativeness reduces extinction risk, increases colonization success and is associated with increased brain size and pallial neuron numbers. However, appropriate laboratory measurements of innovativeness, necessary to conduct targeted experimental studies, have not been clearly established, despite decades of speculation on the most suitable assay. Here we implemented a battery of cognitive tasks on 203 birds of 15 passerine species and tested for relationships at the interspecific and intraspecific levels with ecological metrics of innovation and brain size. We found that species better at solving extractive foraging problems had higher technical innovation rates in the wild and larger brains. By contrast, performance on other cognitive tasks often subsumed under the term behavioural flexibility, namely, associative and reversal learning, as well as self-control, were not related to problem-solving, innovation in the wild or brain size. Our study yields robust support for problem-solving as an accurate experimental proxy of innovation and suggests that novel motor solutions are more important than self-control or learning of modified cues in generating technical innovations in the wild.
Single-step fabrication of liquid gallium nanoparticles via capillary interaction for dynamic structural colours
Authors: Sahu Renu Raman , Ramasamy Alwar Samy , Bhonsle Santosh , Vailshery Mark , S Archana , Kumar Hemant , Das Gupta Tapajyoti 
Published: February 2024

AbstractIncorporating structural coloured materials in flexible and stretchable elastomeric substrates requires numerous steps that compromise their scalability and economic viability for prospective applications in visual sensors and displays. Here we describe a one-step approach for fabricating plasmonic Ga nanostructures embedded in a polydimethylsiloxane substrate exhibiting tunable chromaticity, in response to mechanical stimuli. The process exploits the capillary interactions between uncrosslinked oligomeric chains of the substrate and Ga metal deposited by thermal evaporation, as elucidated by a theoretical model that we developed. By tuning the oligomer content in polydimethylsiloxane, we attain a range of colours covering a substantial gamut in CIE (Commission Internationale de l’Éclairage) coordinates. This mechanochromic flexible substrate shows reversible response to external mechanical stimuli for ~80,000 cycles. We showcase the capabilities of our processing technique by presenting prototypes of reflective displays and sensors for monitoring body parts, smart bandages and the capacity of the nanostructured film to map force in real time.
Topical minoxidil and dietary supplement for the treatment of chemotherapy-induced alopecia in childhood: a retrospective cohort study
Authors: Lee Ji Won , Kang Jeewoo , Choi Jung Yoon , Hong Kyung Taek , Kang Hyoung Jin , Kwon Ohsang 
Published: February 2024

AbstractChemotherapy-induced alopecia (CIA) is a common and debilitating condition in children, with limited research on its characteristics and treatment. Therefore, this study aims to describe the characteristics of pediatric patients with CIA and the treatment outcomes of topical minoxidil and l-cystine, medicinal yeast, and pantothenic acid complex-based dietary supplements (CYP). This retrospective cohort study analyzed data from patients who underwent high-dose conditioning chemotherapy followed by hematopoietic stem cell transplantation and were treated with either topical minoxidil or CYP for CIA between January 2011 and January 2022. Among the 70 patients evaluated, 61 (87.1%) experienced clinical improvement. Patients in the groups with superior treatment outcomes received a greater cumulative amount of minoxidil and underwent treatment for a more extended duration (P < 0.05) than those in the other groups. All 70 (100%) patients received topical minoxidil, and 42 (60%) were administered CYP. Hair thickness was significantly higher in the combination therapy group than in the minoxidil monotherapy group (21.4% vs. 9.3%, P = 0.02). However, only 3 (4.3%) patients reported mild and self-limiting adverse events. In conclusion, our study shows that minoxidil and CYP administration represent viable treatment options for pediatric CIA.
Theoretical study of the synergic relationships between the design parameters in energy-saving building design
Authors: Huo Hai ’E. , Ji YanHong , Qin YuanYuan , Chen ChaoZheng , Yuan Ting 
Published: February 2024

AbstractWith the rapid development of the economy, people have increasingly higher requirements for the comfort of living spaces, and the result is the sharp increase in building energy consumption. Several design parameters influence living space comfort and building energy efficiency. Since the same design standard can include different design parameter combinations, synergic relationships may exist between these criteria for one case. Identifying these synergic relationships requires an inverse problem approach. This paper established a model by combining an improved genetic algorithm (IGA) and numerical calculation to determine the synergic design parameter relationships (e.g. the thermophysical building material properties and energy-saving factors). For $${{\text{I}}}_{{\text{sum}}}= {0} $$

I
sum

=
0

, the shading coefficient significantly influenced the linear function between the thermal conductivity and insulation thickness. In this case, the insulation thickness was exponentially related to the shading coefficient, while the thermal conductivity of the insulation material significantly impacted the synergic relationship. For $${\text{ESR}}{=65}\%$$

ESR

=
65

%

, the insulation thickness was a segmented function of the shading coefficient. The results verified that the proposed model was efficient and reliable for identifying the synergic relationships between energy-saving parameters. In engineering applications, designers can select the optimal design parameter combination based on the relationship curve between the parameters in this paper according to the local market conditions and specific design requirements.
Recycled gold-reduced graphene oxide nanocomposite for efficient adsorption and photocatalytic degradation of crystal violet
Authors: Al-Ansari Sherkawi H. , Gomaa Hassanien , Abdel-Rahim Rabeea D. , Ali Gomaa A. M. , Nagiub Adham M. 
Published: February 2024

AbstractIn this study, gold-reduced graphene oxide (Au@rGO) nanocomposite has been synthesized by repurposing electronic waste and dry batteries. This innovative approach involved utilizing the graphite rod from dry batteries to produce reduced graphene oxide (rGO), which was subsequently modified through the incorporation of gold nanoparticles obtained from recycled electronic waste. This methodology marks a significant breakthrough in electronic waste recycling, presenting a cost-effective and sustainable means of creating novel nanocomposites for applications in photocatalysis and adsorption, particularly in the removal of crystal violet (CV) from aqueous media. The synthesized Au@rGO nanocomposite was characterized using X-ray diffraction, scanning electron microscopy, energy dispersed X-ray, and N2 adsorption/desorption. Parameters that affect the adsorption and photocatalytic degradation of CV dye have been studied in detail. The optimal conditions for CV adsorption and photocatalytic degradation were pH of 10, equilibrium time of 30 min, CV concentration of 10 mg/L and adsorbent dosage of 40 mg. Furthermore, the isotherm and kinetics of CV removal were also studied. The removal of CV dye using adsorption and photocatalytic degradation techniques reached 95% and 99%, respectively. Consequently, the results showed that photocatalytic degradation of CV dye onto the mesoporous Au@rGO nanocomposite is more proper way than the adsorption technique for removing the CV dye from aqueous media. The designed photocatalyst has high efficiency and it can be reused and activated several times so it can be used in real water treatment applications.
Synergistic chemo-photothermal therapy using gold nanorods supported on thiol-functionalized mesoporous silica for lung cancer treatment
Authors: Deinavizadeh Maryam , Kiasat Ali Reza , Shafiei Mohammad , Sabaeian Mohammad , Mirzajani Roya , Zahraei Seyed Mohammadsaleh , Khalili Fateme , Shao Minmin , Wu Aimin , Makvandi Pooyan , Hooshmand Nasrin 
Published: February 2024

AbstractCancer therapy necessitates the development of novel and effective treatment modalities to combat the complexity of this disease. In this project, we propose a synergistic approach by combining chemo-photothermal treatment using gold nanorods (AuNRs) supported on thiol-functionalized mesoporous silica, offering a promising solution for enhanced lung cancer therapy. To begin, mesoporous MCM-41 was synthesized using a surfactant-templated sol–gel method, chosen for its desirable porous structure, excellent biocompatibility, and non-toxic properties. Further, thiol-functionalized MCM-41 was achieved through a simple grafting process, enabling the subsequent synthesis of AuNRs supported on thiol-functionalized MCM-41 (AuNR@S-MCM-41) via a gold-thiol interaction. The nanocomposite was then loaded with the anticancer drug doxorubicin (DOX), resulting in AuNR@S-MCM-41-DOX. Remarkably, the nanocomposite exhibited pH/NIR dual-responsive drug release behaviors, facilitating targeted drug delivery. In addition, it demonstrated exceptional biocompatibility and efficient internalization into A549 lung cancer cells. Notably, the combined photothermal-chemo therapy by AuNR@S-MCM-41-DOX exhibited superior efficacy in killing cancer cells compared to single chemo- or photothermal therapies. This study showcases the potential of the AuNR@S-MCM-41-DOX nanocomposite as a promising candidate for combined chemo-photothermal therapy in lung cancer treatment. The innovative integration of gold nanorods, thiol-functionalized mesoporous silica, and pH/NIR dual-responsive drug release provides a comprehensive and effective therapeutic approach for improved outcomes in lung cancer therapy. Future advancements based on this strategy hold promise for addressing the challenges posed by cancer and transforming patient care.
Polycaprolactone/polyacrylic acid/graphene oxide composite nanofibers as a highly efficient sorbent to remove lead toxic metal from drinking water and apple juice
Authors: Rostami Mohammadreza , Jahed-khaniki Gholamreza , Molaee-aghaee Ebrahim , Shariatifar Nabi , Sani Mahmood Alizadeh , Azami Mahmood , Rezvantalab Sima , Ramezani Soghra , Ghorbani Marjan 
Published: February 2024

AbstractDue to the characteristics of electrospun nanofibers (NFs), they are considered a suitable substrate for the adsorption and removal of heavy metals. Electrospun nanofibers are prepared based on optimized polycaprolactone (PCL, 12 wt%) and polyacrylic acid (PAA, 1 wt%) polymers loaded with graphene oxide nanoparticles (GO NPs, 1 wt%). The morphological, molecular interactions, crystallinity, thermal, hydrophobicity, and biocompatibility properties of NFs are characterized by spectroscopy (scanning electron microscopy, Fourier transform infrared spectroscopy, X-ray diffraction, Thermogravimetric analysis), contact angle, and MTT tests. Finally, the adsorption efficacy of NFs to remove lead (Pb2+) from water and apple juice samples was determined using inductively coupled plasma optical emission spectroscopy (ICP-OES). The average diameter for PCL, PCL/PAA, and PCL/PAA/GO NFs was 137, 500, and 216 nm, respectively. Additionally, the contact angle for PCL, PCL/PAA, and PCL/PAA/GO NFs was obtained at 74.32º, 91.98º, and 94.59º, respectively. The cytotoxicity test has shown non-toxicity for fabricated NFs against the HUVEC endothelial cell line by more than 80% survival during 72 h. Under optimum conditions including pH (= 6), temperature (25 °C), Pb concentration (25 to 50 mg/L), and time (15 to 30 min), the adsorption efficiency was generally between 80 and 97%. The adsorption isotherm model of PCL/PAA/GO NFs in the adsorption of lead metal follows the Langmuir model, and the reaction kinetics follow the pseudo-second-order. PCL/PA/GO NFs have shown adsorption of over 80% in four consecutive cycles. The adsorption efficacy of NFs to remove Pb in apple juice has reached 76%. It is appropriate and useful to use these nanofibers as a high-efficiency adsorbent in water and food systems based on an analysis of their adsorption properties and how well they work.
Radiation exposure lymphocyte damage assessed by γ-H2AX level using flow cytometry
Authors: Chen Zhuoqing , Wakabayashi Hiroshi , Kuroda Rie , Mori Hiroshi , Hiromasa Tomo , Kayano Daiki , Kinuya Seigo 
Published: February 2024

AbstractDNA double-strand breaks (DSBs) are considered the most relevant lesions to the DNA damage of ionizing radiation (IR), and γ-H2AX foci in peripheral blood lymphocytes are regarded as an adequate marker for DSB quantitative studies. This study aimed to investigate IR-induced DNA damage in mice through γ-H2AX fluorescence analyses by flow cytometry (FCM). The levels of γ-H2AX in CD4/CD8/B220-positive lymphocytes were quantified by FCM through mean fluorescence intensity (MFI) values. Peripheral venous blood samples were collected for evaluation, and all the control groups were restrained from irradiation. For external irradiation experiments, the dose-dependency of MFI values and temporal alternations were assessed both in vitro and in vivo. External radiation exposure damage was positively correlated with the absorbed radiation dose, and the lymphocyte recovered from damage within 3 days. I-131 sodium iodide solution (74 MBq) was injected into the mice intraperitoneally for internal irradiation experiments. Gamma counting and γH2AX foci analyses were performed at 1 h and 24 h by the group. The blood-to-blood S values (Sblood←blood) were applied for the blood-absorbed dose estimation. Internal low-dose-irradiation-induced damage was proved to recover within 24 h. The FCM method was found to be an effective way of quantitatively assessing IR-induced DNA damage.