bluuebunny/crossref_metadata_2025_split huggingface dataset:
PI4KIIIβ inhibition reduces rhinovirus associated cell shedding and ciliary dysfunction
Authors: Velkova Simona A. , Petris Alina M. , Lee Dani D.H. , Cardinale Daniela , Moulding Dale , Williamson Richard A. , Beinke Soren , Grace Ken , Hessel Edith M , Belyaev Nikolai N. , Hoegg Tanja , Steiner Michael , Hurst John R , Smyth Rosalind L. , Smith Claire M. , Freestone Primrose , O’Callaghan Christopher 
Published: December 2023

AbstractBackgroundPatients with chronic obstructive pulmonary disease (COPD) experience respiratory exacerbations, many of which are associated with rhinoviruses. Current treatment strategies do not target the pathogenic rhinovirus trigger.Research questionWhat is the immediate effect of rhinovirus on the ciliated respiratory epithelium and can viral replication and epithelial toxicity be reduced by targeted PI4KIIIβ inhibition.MethodsShort (24h) and longer (7 days) rhinovirus infection were explored in primary ciliated airway epithelial cultures from multiple healthy and COPD patients using high-speed video microscopy, viral titration assays and immunofluorescence studies. Ciliated epithelial cultures were pre-treated with a PI4KIIIβ (GSK’533) blocker prior to infection to assess efficacy against rhinovirus. Cytokine and chemokine production were assessed by multiplex immunoassays.ResultsWithin hours of infection rhinovirus co-localised with ciliated cells causing extensive apoptosis-associated shedding of predominantly ciliated cells within 24 hours. Viral replication that peaked at day 1 and cleared by day 7, was associated with dramatic loss of ciliated cells confirmed by reduced ciliary activity and ciliary DNAI2 protein expression. Ciliary beat frequency (CBF) of remaining cilia was significantly reduced by day 7 in cultures from COPD. Infection was partly dependent on PI4KIIIβ with the GSK’533 blocker reducing viral replication while preserving ciliary activity. High levels of pro-inflammatory mediators were secreted by infected cells.ConclusionDecreased ciliation due to rhinovirus infection is likely to impair mucociliary clearance in healthy individuals and COPD patients, contributing to the pathophysiology of COPD exacerbations. PI4KIIIβ inhibition blocks viral replication, helping to preserve ciliary activity.Take home messageRhinovirus replication in the healthy and COPD respiratory epithelium is mediated by PI4KIIIβ and intracellular PI4P platform formation. Inhibition of PI4KIIIβ reduced viral replication and ciliated cell loss.
Investigation of the wear behavior of FeNi36 alloy cut by WEDM method under different loads
Authors: Ceritbinmez Ferhat , Kanca Yusuf , Tuna Ahmet , Kanca Erdoğan 
Published: December 2023

Purpose
FeNi36 (Invar-36) alloy is widely used in the fabrication of molding tools in aerospace industries but there remains a need to improve its wear and friction performance due to its relatively low hardness. The formation of a heat affected zone (HAZ) on the surface of Invar-36 cut by wire electric discharge machining (WEDM) is promising to enhance its tribological properties. This study aims to investigate the tribological performance of WEDM-treated Invar-36 via a ball-on-disk tribometer in dry-sliding conditions.

Design/methodology/approach
The untreated and WEDM-treated Invar-36 surfaces were reciprocated against an alumina ball at a sliding velocity of 40 mm/s, a stroke length of 10 mm and a sliding duration of 125 min under loads of 5, 10 and 20 N. The worn surfaces were characterized using a 2D profilometry and a scanning electron microscope equipped with energy-dispersive spectroscopy.

Findings
The results showed that the WEDM-treated surface had a superior friction coefficient and wear resistance in comparison to the untreated surface, due to the grown HAZ. There was found to be a 9.3%–11.4% decrease in the friction coefficient and a 47%–57% reduction in the wear volume after the WEDM treatment. Both the untreated and WEDM-treated Invar-36 surfaces found abrasion and plastic deformation as the dominant wear mechanisms.

Originality/value
Previous works have not focused on the tribological performance of the WEDM-treated Invar-36 extensively used for molding tools in aerospace industries. Our findings provide compelling evidence that the WEDM treatment improved the wear and friction performance of Invar-36 alloy because of the grown HAZ.
A prelude to statistics in Wasserstein metric spaces
Authors: Le Chon Van , Pham Uyen Hoang 
Published: December 2023

PurposeThis paper aims mainly at introducing applied statisticians and econometricians to the current research methodology with non-Euclidean data sets. Specifically, it provides the basis and rationale for statistics in Wasserstein space, where the metric on probability measures is taken as a Wasserstein metric arising from optimal transport theory.Design/methodology/approachThe authors spell out the basis and rationale for using Wasserstein metrics on the data space of (random) probability measures.FindingsIn elaborating the new statistical analysis of non-Euclidean data sets, the paper illustrates the generalization of traditional aspects of statistical inference following Frechet's program.Originality/valueBesides the elaboration of research methodology for a new data analysis, the paper discusses the applications of Wasserstein metrics to the robustness of financial risk measures.
Ambidextrous cultural values in the management of organisational ambidexterity
Authors: Lloria M. Begoña , Burbano Leydy 
Published: December 2023

PurposeThis paper first analyses the direct effect of quality management practices (QMPs) on organisational ambidexterity (OA). It then analyses the mediating influence of the values of ambidextrous culture (AC). A novel theoretical model is tested in a quantitative study of the organic agri-food sector.Design/methodology/approachQuantitative methods and an online survey were used to collect and analyse 239 valid questionnaire responses. The data analysis method was partial least squares (PLS).FindingsThere is a relationship between QMPs and OA. AC partially mediates this link, strengthening the direct relationship between the two variables.Originality/valueThe proposed model is novel and creates opportunities for new lines of research. The concept of QMPs is considered in all its dimensions (processes, people, customers and suppliers). The study reaffirms the importance of the novel concept of AC in the literature. In this study, OA is defined in terms of the balanced processes of exploitation and exploration. The choice of sector is another original feature of the study.
Exploring the determinants of purchase intention of organic consumers for organic food items: an exploratory study in India
Authors: Garg Shubham , Narwal Karam Pal , Kumar Sanjeev 
Published: December 2023

PurposeThe ongoing transition in the attitude of consumers toward health and environment has a direct implication on the organic food industries, making it necessary to examine the drivers of the purchase intention of organic food items, specifically in developing economies like India. Therefore, this study tries to frame and validate the instrumental scale by collecting data from 574 organic food item consumers to examine the determinants of purchase intention among consumers in India.Design/methodology/approachThis study has employed advanced statistical tools i.e. Exploratory Factor Analysis (EFA), Confirmatory Factor Analysis (CFA), Harmon’s single factor test and other statistical measures using SPSS and AMOS 23, for framing and validating the instrumental scale for this study.FindingsThe results of EFA explain 67.714% variance of total research variable variance with six major constructs. Moreover, the result of the CFA confirms the six factors and the proposed instrumental scale. The finding explicates that health consciousness, ecological trustworthiness and functional value are the major drivers of the purchase intention of organic food items.Practical implicationsThis study has major policy implications for organic producers, processor and marketers for understanding the complex phenomenon of organic consumer behavior. The result explains that marketers and producers should adopt ad hoc marketing strategies that aim to promote the organic food items as healthy and safe.Originality/valueThere is hardly any study that has proposed and validated an instrumental scale with these factors collectively in India for studying the purchase intention of organic food consumers in India.
Should luxury brands display their logos prominently? Implications for brand authenticity, coolness and behavioral intentions
Authors: Shukla Paurav , Cakici N. Meltem , Khalifa Dina 
Published: December 2023

Purpose
Extant research captures the signaling and attitudinal effects of luxury brand prominence strategy; however, little is known about the underlying mechanisms that drive this effect. This study aims to uncover brand authenticity and brand coolness as parallel mediators driving the effects of brand prominence on luxury purchase intentions and explores the moderating role of consumers’ self-brand connection.

Design/methodology/approach
The research consisted of three experiments. Study 1 (n = 121) explored the direct effects of brand prominence among Chinese consumers. Using a sample of Turkish consumers (n = 115), Study 2, measured the mediation effects of brand authenticity and brand coolness. Study 3 (n = 211) examined how self-brand connection moderated the mediation effects among British customers.

Findings
A luxury brand prominence strategy leads to negative perceptions of coolness and authenticity and, in turn, reduces purchase intentions. The negative effect of brand prominence is even more pronounced among consumers with high self-brand connection.

Research limitations/implications
The study elaborates on how brand prominence informs consumers’ perceptions of authenticity and coolness. In examining the role of self-brand connection, the study reveals a theoretically and managerially relevant boundary condition of this focal effect.

Practical implications
The research highlights how luxury brands can use differing brand prominence strategies. This research informs brand managers on how to enhance brand authenticity and coolness while managing self-brand connection.

Originality/value
The study extends the luxury branding literature by explaining the brand prominence effect through the parallel mediators of brand authenticity and brand coolness. In contrast to extant research, the findings show that the negative effect of brand prominence is particularly strong among consumers with high self-brand connection.
Healthy prison cultures: factors influencing male prisoners’ engagement in exercise and subsequent healthy behaviours
Authors: Hammond Hannah , Meek Rosie , Glorney Emily 
Published: December 2023

Purpose
The purpose of this paper is to identify the factors which influence male prisoners’ motivation for, and engagement in, exercise and subsequent healthy behaviours.

Design/methodology/approach
The first authors conducted 20 semi-structured interviews with male prisoners inside an English medium-security male prison. Interviews were recorded and transcribed, themes were identified using thematic analysis and a critical realist perspective applied to understand objective processes behind prisoners’ experiences and shared meanings of exercise and engaging in healthy behaviours in prison.

Findings
Emerging themes indicate that in the context of healthy behaviours male prisoners aspired to a masculine ideal that was characterised by a culture of either adaptive behaviours, or maladaptive behaviours. The former fostered an adaptive exercise culture which promoted psychological well-being through an autonomy-supportive environment, consequently internalising motivation and minimising perceived barriers to engaging in healthy behaviours. Conversely, a culture of maladaptive behaviours fostered a maladaptive exercise culture which led to negative psychological well-being, underpinned by external forms of motivation which emphasised barriers to engaging in healthy behaviours.

Practical implications
Findings emphasise the need for prisons to promote an internal perceived locus of control for male prisoners when engaging in healthy behaviours.

Originality/value
The authors adopt a rare interdisciplinary approach combining a psychological theory of motivation and criminological perspectives of prison culture to understand how best to minimise the impact of prisons as an institution on the psychological well-being of male prisoners.
Prison food and the carceral experience: a systematic review
Authors: Johnson Claire , Gagnon Samuel , Goguen Pierre , LeBlanc Caroline P. 
Published: December 2023

Purpose
This study aims to focus on studies that qualitatively explore prison food experience. The goal is to elaborate a framework to better understand how prison food shapes the worldwide carceral experience.

Design/methodology/approach
This systematic literature review was based on the Preferred Reporting Items for Systematic Reviews and Meta-Analysis (PRISMA) statement. It consists of four phases: identifying the studies, screening the studies, evaluating the eligibility of screened studies and inclusion of studies. After the four phases, ten studies (nine qualitative studies and one with mixed methods) were included in the review.

Findings
There is a consensus among the researchers in the reviewed literature that prison food shapes the carceral experience. More specifically, four themes that encompass the experience of people with prison food emerged from the reviewed literature: food appreciation (taste of the prison food and perceived nutritional value), food logistics (preparation, distribution and consumption), food variety (institutional menu and commissary store) and food relationships (symbol of caring or power or punishment).

Originality/value
The literature reviewed demonstrated that when incarcerated individuals have a negative view of prison food, the carceral experience is negatively impacted. This systematic review identified four dimensions that encompass the food experience within the prison environment, providing a framework for navigating this subject.
Social influence processes within MMORPG guilds: a mixed-methods approach of nomological network analysis
Authors: Wang Kai , Tai Chi-Feng , Hu Han-fen 
Published: December 2023

PurposeFocusing on the social influence processes in the context of massively multiplayer online role-playing games (MMORPGs), this study aims to investigate the nomological network of social influence factors, a topic seldom explicitly articulated in the literature in this unique context.Design/methodology/approachThis study adopts a mixed-methods approach to develop and test a context-specific model of social influence processes in MMORPGs. First, the authors conducted qualitative interviews with MMORPG players to identify the drivers shaping players' perceptions of social influences. Second, the authors formulated and tested a research model with quantitative data collected from 450 respondents of an online survey.FindingsThrough the qualitative study, the authors identify leader enthusiasm, social support and social presence as the critical drivers of social influence factors. The result of the quantitative study validates the influences of the critical drivers and demonstrates the impact of social influences on MMORPG players' we-intention to continue playing games.Originality/valueThis research extends the social influence theory by identifying contextualized drivers that shape MMORPG players' perception of social influences determining their we-intention to continue playing games. MMORPG service providers can draw on these drivers to leverage social influences to increase players' we-intention of continuance.
Deep learning applications in investment portfolio management: a systematic literature review
Authors: Novykov Volodymyr , Bilson Christopher , Gepp Adrian , Harris Geoff , Vanstone Bruce James 
Published: December 2023

PurposeMachine learning (ML), and deep learning in particular, is gaining traction across a myriad of real-life applications. Portfolio management is no exception. This paper provides a systematic literature review of deep learning applications for portfolio management. The findings are likely to be valuable for industry practitioners and researchers alike, experimenting with novel portfolio management approaches and furthering investment management practice.Design/methodology/approachThis review follows the guidance and methodology of Linnenluecke et al. (2020), Massaro et al. (2016) and Fisch and Block (2018) to first identify relevant literature based on an appropriately developed search phrase, filter the resultant set of publications and present descriptive and analytical findings of the research itself and its metadata.FindingsThe authors find a strong dominance of reinforcement learning algorithms applied to the field, given their through-time portfolio management capabilities. Other well-known deep learning models, such as convolutional neural network (CNN) and recurrent neural network (RNN) and its derivatives, have shown to be well-suited for time-series forecasting. Most recently, the number of papers published in the field has been increasing, potentially driven by computational advances, hardware accessibility and data availability. The review shows several promising applications and identifies future research opportunities, including better balance on the risk-reward spectrum, novel ways to reduce data dimensionality and pre-process the inputs, stronger focus on direct weights generation, novel deep learning architectures and consistent data choices.Originality/valueSeveral systematic reviews have been conducted with a broader focus of ML applications in finance. However, to the best of the authors’ knowledge, this is the first review to focus on deep learning architectures and their applications in the investment portfolio management problem. The review also presents a novel universal taxonomy of models used.
The research on the application of self-propagating interconnection technology in silicon optical transceiver module for aerospace
Authors: Chu Fei , Chen Hongzhuan , Zhou Zheng , Feng Changlei , Zhang Tao 
Published: December 2023

Purpose
This paper aims to investigate the bonding of the photonic integrated circuit (PIC) chip with the heat sink using the AlNi self-propagating soldering method.

Design/methodology/approach
Compared to industrial optical modules, optical modules for aerospace applications require better reliability and stability, which is hard to achieve via the dispensing adhesive process that is used for traditional industrial optical modules. In this paper, 25 µm SAC305 solder foils and the AlNi nanofoil heat source were used to bond the back of the PIC chip with the heat sink. The temperature field and temperature history were analyzed by the finite element analysis (FEA) method. The junction-to-case thermal resistance is 0.0353°C/W and reduced by 85% compared with the UV hybrid epoxy joint.

Findings
The self-propagating reaction ends within 2.82 ms. The maximum temperature in the PIC operating area during the process is 368.5°C. The maximum heating and cooling rates of the solder were 1.39 × 107°C/s and −5.15 × 106°C/s, respectively. The microstructure of SAC305 under self-propagating reaction heating is more refined than the microstructure of SAC305 under reflow. The porosity of the heat sink-SAC305-PIC chip self-propagating joint is only 4.7%. Several metastable phases appear as AuSn3.4 and AgSn3.

Originality/value
A new bonding technology was used to form the bonding between the PIC chip with the heat sink for the aerospace optical module. The reliability and thermal resistance of the joint are better than that of the UV hybrid epoxy joint.
Wales and Autism: the impact of philanthropy matched by ambition
Authors: Morgan Hugh 
Published: December 2023

Purpose
The purpose of this paper is to place on record the impact made on government policy and research by Autism Cymru, a small charity that existed in Wales between 2001 and 2014. The success of Autism Cymru resulted directly from philanthropic funding, applied with strategic vision and genuine ambition.

Design/methodology/approach
A retrospective, chronological viewpoint highlighting the creative process, drawing upon records held by the charity.

Findings
Autism Cymru initiated the concept and played a crucial role in steering the development of government policy for autism in Wales between 2001 and 2011. The charity also drove forward the initiative, which led to the establishment of the Wales Autism Research Centre at Cardiff University in 2010. This paper demonstrates that with astute philanthropic support, small learning disability/autism charities can elicit structural and sustainable change at the national level, leading to wide-ranging benefits for the communities they represent.

Originality/value
The strategic approach taken over 20 years ago in Wales by Autism Cymru, which led to the Welsh Government’s ASD Strategic Action Plan for Wales (Welsh Government, 2011), set in place a national policy model, which was then followed by The Scottish Strategy for Autism and the Northern Ireland Autism Strategy (Department of Health, 2013>; Scottish Government, 2011). The insightful and tenacious method used by Autism Cymru remains relevant today, demonstrating that any small charity supported by shrewd philanthropic funding can punch well above its weight by taking a planned, ambitious and strategic approach to policy, research and practice.
Commentary on “Wales and Autism: the impact of philanthropy matched with ambition”
Authors: Storey Catherine 
Published: December 2023

Purpose
This paper is a commentary that aims to address themes arising from the article by Morgan titled “Wales and Autism: The Impact of Philanthropy Matched with Ambition”.

Design/methodology/approach
This opinion piece considers the broader impact of stakeholder engagement in the field of autism, including how the dissemination of evidence-based support could be made more accessible for autistic people, their families and carers and philanthropists.

Findings
This paper highlights the link between stakeholder engagement and meaningful change in policy and practice in the field of autism. It highlights the need for philanthropists to invest in evidence-based support but highlights the difficulty in identifying and accessing such support. This piece supports the use of evidence and gap maps (EGMs) to increase the accessibility of autism research and evidence.

Originality/value
While stakeholder engagement is encouragingly rising in this field, most of the evidence is held in academic journals, which are behind paywalls and, therefore, inaccessible to many autistic people, their families, carers and associated professionals. Displaying evidence using EGMs provides an accessible way for autistic people and those who support them to identify possible avenues of support quickly and allows philanthropists to direct research funding to areas of high priority.