bluuebunny/crossref_metadata_2025_split huggingface dataset:
Amelioration of Behavioral and Cognitive Impairment of Ethanolic Leaf Extract of Ziziphus Talanai Against MSG in Mice
Authors: Nolasco Glen , Escoto Graciela Ann , David Lourdes Fatima , Te Aaron Carl , Yamauchi Frienchie Ann 
Published: December 2023

Ziziphus talanai is an endemic plant species in the Philippines. Recently, this plant's phytochemical analysis revealed pivotal compounds with different pharmaceutical properties, including the neuroprotective activity in the mice cerebellum. Nonetheless, the scarcity of information on the neuroprotective potential of this plant has been a focal point. Thus, this study aimed to evaluate the neuroprotective potential of Z. talanai extract against MSG-induced aberrations in mice. A total of 24 mice were distributed and administered 9000mg/kg of MSG (T-), MSG and 1000mg/kg of L-taurine (T+), 100% of extract (T1), MSG, and 25% extract (T2), MSG and 50% of the extract, MSG and 75% extract, and MSG and 100% of the extract. The results of the test crawling along the rope showed that mice treated with MSG exhibited anxiety-like behavior, while mice treated with L-taurine managed to surpass the atrocious effect of MSG. In mice treated with the extracts, it is revealed that there is anxiolytic effect that has direct relation between the concentration and results. The results of the Y-maze test obtained significant differences between the MSG-treated group versus extract alone, L-taurine, 50%, 75%, and 100% extract. Interestingly, a 75% concentration of the plant extract was the most promising of the group results. These justify the ameliorative potential of Z. talanai extract on the behavior deficits and cognitive impairment of mice treated with MSG.
Neuroprotective effect of 2-ethyl-6-methyl-3-hydroxypyridine succinate on the sciatic nerve and its segmental centers in experimental paclitaxel-induced peripheral neuropathy
Authors: Herashchenko S. B. , Ostrovskyi M. M. , Kulynych H. B. , Markiv I. M. 
Published: December 2023

Up to 60 % of patients suffer from the neurotoxicity of the chemotherapy drug Paclitaxel, namely paclitaxel-induced peripheral neuropathy (PIPN), during the treatment of breast cancer, ovarian cancer, and non-small cell lung cancer. Of these, up to 25 % of patients require modification of the paclitaxel treatment regimen, including dose reduction, delay, or discontinuation of therapy. Previous attempts to use neuroprotective agents in humans and in animal models have not shown sufficient efficacy in preventing or significantly reducing the manifestations of PIPN. The aim of our study was to study the effect of the neuroprotective agent 2-ethyl-6-methyl-3-hydroxypyridine succinate (HS) on the morpho-functional parameters of the sciatic nerve and its segmental centers in experimental PIPN. In the experiment, 56 white rats were used, which were injected intraperitoneally with Paclitaxel at a dose of 2 mg/kg of body weight 4 times after one day, after which the animals were divided into an experimental group – 24 animals that were injected with HS and a control group (24 animals, injection of water for injections). The method of studying mechanical allodynia was von Frey monofilaments, thermal hyperalgesia was studied by the hot plate test, and the electron microscopic examination was carried out according to generally accepted methods and studied with the help of a PEM-125 K electron microscope. The results of the hot plate test and the use of von Frey monofilaments showed that the use of HS reliably reduces manifestations of PIPN on the 7th, 14th and 28th days of the experiment. In rats treated with HS, destructive-dystrophic phenomena in the myelin nerve fibers of the sciatic nerve are less pronounced, and in individual fibers in the axon, phenomena of incomplete splitting of mitochondria with the formation of vacuoles filled with medium electron density contents are observed, and small young mitochondria are also visualized. During the first 28 days, we noted less pronounced destructive-dystrophic changes in the neurons of the spinal cord nodes, namely: chromatolysis of light and dark neurons and swelling of their cytoplasm, phenomena of neuronophagy in gliocytes, hypertrophy of certain areas of the myelin sheath. The results of the electron microscopic study are fully consistent with the data of neurophysiological studies and indicate the possibility of using HS as an effective neuroprotector in PIPN.
Possibilities to apply comparative approach to valuation for Russian companies
Authors: Gezha Alina Vladimirovna 
Published: December 2023

This article considers the problems of applying the comparative approach to the valuation of Russian companies. The methods of comparative approach to business valuation are studied. PJSC Acron value by the method of companies – analogues is calculated. It is concluded that the method of companies – analogues with multiplicators is the most applicable for Russian companies and whole market.
A Case of Covid-19 Respiratory Illness with Subsequent Seizure and Hemiparesis
Authors: Hamidi Ava , Sabayan Behnam , Sorond Frazaneh , Nemeth Alexander J , Borhani-haghighi Afshin 
Published: December 2023

Background: Neurological manifestations and complications are common in viral infections, and they are significant sources for clinical deterioration and poor clinical outcomes. Case report: The current report presents a 38year-old man with Covid-19 respiratory illness who subsequently developed neurological complications and clinical worsening leading to death. This patient sought medical attention after five days of progressive cough, fever, and dyspnea. On arrival in the emergency room, he was found to have hypoxic respiratory failure resulting in intubation and intensive care unit (ICU) admission. Chest CT scan was characteristic for Covid-19 infection, and PCR test on tracheal samples confirmed the diagnosis. On day nine of admission, he developed generalized tonic colonic seizure associated with deterioration of mental status and hemiparesis. Repeated brain CT scans showed subcortical hypoattenuation with associated sulcal effacement in the left occipital and posterior parietal lobes concerning for ischemic changes. The patient passed away on day 17 despite supportive measures. Conclusion: This observation and recent evidence on Covid-19 CNS involvement highlight the need for further studies on early recognition of neurological complications in Covid-19 patients. [GMJ.2020;9:e1915]
Creating a software prototype of the face recognition system for educational institutions on the "1C:Enterprise" platform
Authors: Barabash D. A. , Panov P. M. 
Published: December 2023

The use of information technology entails not only huge benefits but also a large number of new threats. One of the most dangerous of them is data leaks, as they undermine consumer confidence and can lead to business shutdowns. Educational organizations that use applications on the 1C platform in their work face a similar problem. The solution in this case may be to improve the authorization process by adding one more step to it — face recognition.For optimal design of this authorization method, it is necessary to develop the program architecture considering the current business requirements of educational organizations and to develop a software prototype ready for integration into current educational software solutions.The article provides an example of the above architecture and the application created on its basis. Further, they can be integrated into any system based on “1C:Enterprise”. To meet the requirements for the system, the most appropriate architecture is a “client — server” with a separate server dedicated to the database. Python programming language is used, network communication is organized according to REST principles using GET method and HTTP protocol, photo data transfer is in JSON format.
Use of artificial intelligence methods to assess competencies during testing
Authors: Gusyatnikov V. N. , Sokolova T. N. , Bezrukov A. I. , Kayukova I. V. 
Published: December 2023

According to modern standards of higher education (FSES 3++), teaching is aimed at developing a set of universal, general professional, and professional competencies in a graduate. In this regard, the problem of assessing the level of their formation arises. Since competence is a multidisciplinary concept, its assessment requires designing a task that simulates a real situation, which may require complex knowledge and skills related to different areas of knowledge. One of the modern tools for current and final control is computer testing. In this case, during one testing session, it is desirable to evaluate several competencies at once with a limited number of tasks. The task is relevant, because in the currently used classical one-dimensional one-, two- and three-parameter Rasch—Birnbaum models, it is assumed that all tasks in the test belong to the same area of knowledge.The purpose of the article is to propose a methodology for the intellectual assessment of several competencies based on the results of one testing session, based on the modification of the Bayes algorithm, in which the choice of the next task is carried out as a result of analyzing the entropy (uncertainty) of the subject’s attribution to typical combinations (patterns) of preparedness levels for different competencies.An original technique for regularizing the Bayes algorithm based on the assessment of the change in the entropy of the probability distribution over patterns and the Kullback—Leibler divergence has been developed, which makes it possible to identify the moment when the student gives an answer that does not correspond to what is expected from them, based on the analysis of previous answers. The proposed technique not only increases the stability of the Bayes algorithm for measuring the probability of a student belonging to a given pattern by slightly increasing the required number of tasks but also allows to model the actions of an examiner in the process of competencies assessment. In general, the developed approach makes it possible to objectively assess the levels of formation of several competencies based on the results of single test.
Phytochemical constituents of bark essential oils of Cinnamomum zeylanicum Blume and effects on liver tissue of rats
Authors: Duaa Abd Alazem Amran  , Karim H. Al-Derawi  , Al-Saadi Sahar 
Published: December 2023

Cinnamomum zeylanicum Blume is an evergreen tropical tree belonging to the Lauraceae family; it is a useful plant in traditional and modern medicines. Essential oils of Cinnamomum zeylanicum were prepared and identified using gas chromatography–mass spectrometry (GC-MS). For histological study 80 adult male rats were employed in this study. It is the same weight (30 ±5 gm) and 75 days in age. The animals were divided into 4 groups, with ten rats in each group. The results indicated that C. zeylanicum bark contained 27 different phytochemical components. The main components included Cinnamaldehyde (2-Propenal, 3-phenyl-) (46.46%), 9-Methoxybicyclo, [6.1.0] nona-2,4,6-triene (31.31%), alpha-, Muurolene (7.14%) and Copaene (1.63%). Sections of livers were examined for histological abnormalities, such as the breakdown of the liver architecture and increased inflammation, in comparison to control samples, some hepatocytes were swollen with pyknotic, large nuclei and dilated sinusoids. As well as in the rats treated with noticed sever congestion of central vein (CV), degeneration and sluggish of endothelial lining larger, Bile ducts hyperplasia and necrotic hepatocytes. It can be deduced that the main component of cinnamon bark oil is cinnamaldehyde and the liver displayed some tissue changes, including hepatocyte necrosis and the existence of steatosis foci. Histological and cellular changes in liver tissue were dramatically attenuated by C. zeylanicum essential oil.
Dementia Care Class Meningkatkan Sikap Caregiver Informal dalam Perawatan Demensia Berbasis Masyarakat
Authors: Lestari Diana Tri , Jauhar Muhamad , Rahmawati Ashri Maulida 
Published: December 2023

ENGLISHDementia develops rapidly as the number of elderly and degenerative diseases increases. Dementia makes the quality of life reduced so it needs efforts to prevent and treat dementia. Handling is carried out comprehensively, so there is a need for informal caregiver capacity building in community-based dementia care. The purpose of this study was to identify the effect of dementia care class on attitudes in community-based dementia care. The study design used pre-experiment with pre and post-test types with the control group. This research was conducted in the Kaliwungu and Dawe Health Center, Kudus Regency from October 2022 to April 2023. The study sample was 24 informal caregivers for each intervention and control group through purposive sampling techniques. The research instrument used the Alzheimer's Disease Knowledge Scale (ADKS) and the Dementia Care Attitude Scale (DCAS). Data analysis using Mann Whitney. The results showed that there was an influence of dementia care class on informal caregiver attitudes in community-based dementia care with a value of p = 0.000 (p < 0.05). These learning models and media can be integrated into elderly posyandu and elderly health programs in health care facilities in community-based dementia management. INDONESIADemensia berkembang dengan cepat dan berat seiring meningkatnya jumlah lansia serta penyakit degeneratif. Demensia membuat kualitas hidup berkurang bahkan disabilitas sehingga perlu upaya pencegahan dan penanganan demensia. Penanganan dilakukan secara menyeluruh, sehingga perlu adanya program peningkatan kapasitas caregiver informal dalam perawatan demensia berbasis masyarakat. Tujuan penelitian ini yaitu mengidentifikasi pengaruh dementia care class terhadap sikap dalam perawatan demensia berbasis masyarakat. Desain penelitian menggunakan pre-eksperimen dengan jenis pre dan post-test with control group. Penelitian ini dilakukan di wilayah Kerja UPTD Puskesmas Kaliwungu dan Dawe Kabupaten Kudus pada bulan oktober 2022-April 2023. Sampel penelitian sebanyak 24 caregiver informal untuk masing-masing kelompok intervensi dan kontrol melalui teknik purposive sampling. Instrument penelitian menggunakan Alzheimer’s Disease Knowledge Scale (ADKS), Dementia Care Attitude Scale (DCAS), dan Kuesioner Self-Confidence about Dementia Care Skills. Analisis data menggunakan Mann Whitney. Hasil penelitian menunjukkan terdapat pengaruh dementia care class terhadap sikap caregiver informal dalam perawatan demensia berbasis masyarakat dengan nilai p=0,000 (p<0,05). Model dan media pembelajaran ini dapat diintegrasikan dalam posyandu lansia dan program kesehatan lansia di fasilitas layanan kesehatan dalam manajemen demensia berbasis masyarakat.
Analisis Perubahan Kerapatan Vegetasi Pegunungan Kendeng Utara Kabupaten Pati Menggunakan Citra Sentinel-2A
Authors: Adiguna Wildansyah Firdaus , Agista Devi Ega 
Published: December 2023

ENGLISHThe landform of Pati Regency’s part of North Kendeng Mountains which is located on the south of Pati Regency (DONE). Land use in this area is dominated by forest areas and dry agricultural land. Reduced vegetation due to misuse of space and resources is a problem that causes geological and hydrological disasters in these mountains and the areas below them. This study aims to determine changes and condition of vegetation area in the North Kendeng Mountains in Pati Regency. The method used to determine the density of vegetation in this study is based on the Normalized Difference Vegetation Index (NDVI) analysis using Sentinel-2A imagery recording in 2017 and 2022. Vegetation conditions are divided into dense, fairly dense, non-dense, non-vegetative, and water/cloud vegetation classifications. Based on the results of image processing, the dense vegetation class did not experience the highest increase in area of 359.68 hectares. The highest decrease in area was found in the fairly dense vegetation class with an area of 243.34 hectares. The decrease in vegetation class decreased by 175.12 hectares. The non-vegetation class increased by 58.51 hectares and the body of water/cloud area increased by 0.27 hectares. The results of the research on the case of land use change in the North Kendeng Mountains in Pati Regency. INDONESIAKabupaten Pati memiliki bentang alam berupa Pegunungan Kendeng Utara yang berada di sisi selatan Kabupaten Pati. Penggunaan lahan di wilayah ini didominasi oleh kawasan hutan dan lahan pertanian kering. Vegetasi yang berkurang akibat kesalahan pemanfaatan ruang dan sumber daya menjadi permasalahan yang menyebabkan timbulnya bencana geologi maupun hidrologi di pegunungan ini dan kawasan di bawahnya. Penelitian ini bertujuan untuk mengetahui perubahan luas dan kondisi vegetasi di Pegunungan Kendeng Utara di Kabupaten Pati. Metode yang digunakan dalam penelitian ini yaitu analisis indeks vegetasi Normalized Difference Vegetation Index (NDVI) dengan memanfaatkan citra Sentinel-2A tahun perekaman 2017 dan 2022. Kondisi vegetasi dibagi dengan klasifikasi vegetasi rapat, cukup rapat, tidak rapat, non vegetasi, dan air/awan. Berdasarkan hasil pengolahan citra, kelas vegetasi tidak rapat mengalami penambahan luas tertinggi, sebesar 359,68 hektar. Penurunan luas tertinggi terdapat pada kelas vegetasi cukup rapat dengan pengurangan seluas 243,34 hektar. Penurunan kelas vegetasi rapat berkurang seluas 175,12 hektar. Kelas non vegetasi bertambah 58,51 hektar dan luas badan air/awan bertambah 0,27 hektar. Hasil penelitian menunjukkan terjadinya peralihan fungsi lahan Pegunungan Kendeng Utara di Kabupaten Pati.
Analisis Tingkat Kepuasan dan Loyalitas Konsumen Kopi Tempur
Authors: Setyaningsih Dewi , Mukson Mukson , Santoso Siswanto Imam 
Published: December 2023

ENGLISHSatisfaction is the feeling of consumers after using a product, then represented consumer appraisal toward the successfulnnes of that product. Meanwhile, loyalty is the fulfillment of consumer expectations that triggers them to remain loyal to the product. The study aims to analyze consumer satisfaction and loyalty. The measurement of consumer satisfaction involved 27 atributes, whilst consumer loyalty analysis including 4 variables. This study involved 100 respondents that were chosen through accidental sampling. The data were obtained through survey method using questionnaire and interview. The consumer satisfaction was measured using Importance Performance Analysis (IPA) and Customer Satisfaction Index (CSI) methods, while consumer loyalty was analyzed using linear regression. IPA analysis showed that nearly a half of atributes were located in Quadran II, meant those should be maintened and 10 atributes were in Quadran III, meant those were considered as lower priorities. CSI analysis resulted consumer analysis was on satisfied level (79,5%), mainly regarding on facillity and service provisions. Next, consumer satisfaction was determined simultaneously by product quality, price, promotion, and taste. Furthermore, product quality and taste contributed directly and indirectly (through costumer satisfaction) to costumer loyalty, while location and price only have indirect contribution (through satisfcation) to costumer loyalty. INDONESIAKepuasan adalah perasaan konsumen setalah menggunakan produk yang kemudian melakukan penilaian terhadap keberhasilan produk tersebut, sedangkan loyalitas merupakan terpenuhinya harapan konsumen yang memicu untuk tetap setia tehadap produk. Penelitian bertujuan untuk menganalisis tingkat kepuasan serta loyalitas konsumen. Pengukuran kepuasan konsumen melibatkan 27 atribut, sedangkan analisis loyalitas mencakup 4 variabel. Data diperoleh dari metode survei dengan menggunakan kuesioner dan wawancara. Kepuasan konsumen diukur menggunakan metode Importance Performance Analysis (IPA) dan Customer Satisfaction Index (CSI), sedangkan loyalitas konsumen dianalisis menggunakan regresi linier. Analisis IPA menunjukkan bahwa hampir separuh atribut berada pada kuadran II yang berarti harus dipertahankan dan 10 atribut pada kuadran III yang berarti atribut termasuk dalam prioritas rendah. Analisis CSI menghasilkan analisis konsumen berada pada tingkat puas (79,56%), terutama terkait fasilitas dan penyediaan layanan. Selanjutnya, kepuasan konsumen dipengaruhi oleh kualitas produk, location, taste promosi, dan price. Sementara itu, kualitas produk dan rasa berpengaruh secara langsung maupun berpengaruh tidak langsung (melalui kepuasan) terhadap loyalitas, sedangkan tempat dan harga hanya berpengaruh secara tidak langsung (melalui kepuasan) terhadap loyalitas.
Microalgae (Chlorella vulgaris) attenuates aflatoxin-associated renal injury
Authors: Abdeen Ahmed , Elsabagh Rasha , Elbasuni Sawsan S. , Said Alshaimaa M. , Abdelkader Afaf , El-Far Ali H. , Ibrahim Samah F. , Mihaela Ostan , Fericean Liana , Abdelfattah Abdelfattah M. , El-Hewaity Mohamed , Elbarbary Nady , Kadah Amgad Y. , Ibrahim Samar S. 
Published: December 2023

Introduction: Aflatoxins (AFT) are ubiquitous environmental pollutants that are extremely dangerous for both human beings as well as animals. A safe, effective, and considerate strategy is therefore credited with controlling AFT intoxication. Therefore, our study aimed to evaluate the mitigating properties of Chlorella vulgaris (ChV) against AFT-induced nephrotoxicity and altered egg quality.Methods: Quails were randomized into Control group (receiving a normal diet); ChV group (1 g/kg diet); AFT group (receiving an AFT-containing diet); and the AFT-ChV group were given both treatments.Results and discussion: AFT provoked kidney injury, exhibited by increased renal biochemical parameters and reduced protein levels. Malondialdehyde (MDA) levels dramatically increased as a consequence of AFT exposure, and glutathione (GSH) levels, superoxide dismutase (SOD), and glutathione peroxidase (GPx) activities were also decreased. Substantial up-modulation of the mRNA expression of the inflammatory cytokines (TNF-α, IL-1β, and IL-6) was additionally reported. Furthermore, AFT residues were detected in the egg compromising its quality and nutritional value. Contrarily, ChV supplemented diet suppressed the AFT-prompted oxidative stress and inflammation, together with enhancing the nutritional value and quality of eggs and decreasing AFT residues. These beneficial impacts are proposed to be attributed to its antioxidant and nutritional ingredients. The molecular docking dynamics confirmed the inflammatory and apoptotic protein targets for ChV. Our findings recommend that adding ChV supplements to foods might guard against nephrotoxicity brought on by AFT exposure.