bluuebunny/crossref_metadata_2025_split huggingface dataset:
Experience of discrimination reported during pregnancy and infant's emerging effortful control
Authors: Rivera Kenia M. , D'Anna‐Hernandez Kimberly L. , Hankin Benjamin L. , Davis Elysia Poggi , Doom Jenalee R. 
Published: January 2024

AbstractDiscrimination reported during pregnancy is associated with poorer offspring emotional outcomes. Links with effortful control have yet to be examined. This study investigated whether pregnant individuals’ reports of lifetime racial/ethnic discrimination and everyday discrimination (including but not specific to race/ethnicity) reported during pregnancy were associated with offspring emerging effortful control at 6 months of age. Pregnant individuals (N = 174) and their offspring (93 female infants) participated. During pregnancy, participants completed two discrimination measures: (1) lifetime experience of racial/ethnic discrimination, and (2) everyday discrimination (not specific to race/ethnicity). Parents completed the Infant Behavior Questionnaire—Revised when infants were 6 months old to assess orienting/regulation, a measure of emerging effortful control. Analyses were conducted in a subsample with racially/ethnically marginalized participants and then everyday discrimination analyses were repeated in the full sample. For racially/ethnically marginalized participants, greater everyday discrimination (β = −.27, p = .01) but not greater lifetime experience of racial/ethnic discrimination (β = −.21, p = .06) was associated with poorer infant emerging effortful control. In the full sample, greater everyday discrimination was associated with poorer infant emerging effortful control (β = −.24, p = .002). Greater perceived stress, but not depressive symptoms, at 2 months postnatal mediated the association between everyday discrimination and emerging effortful control. Further research should examine additional biological and behavioral mechanisms by which discrimination reported during pregnancy may affect offspring emerging effortful control.
Real‐world glycaemic outcomes in patients with type 1 diabetes using glucose sensors—Experience from a single centre in Dublin
Authors: Lyons Robert E. , Abdul Wahab Roshaida , Goh Sue Yee , Breen Cathy , Rhynehart Amanda , O'Scannail Mary , Kelly Hannah Jade , Neff Karl , O'Shea Donal , Canavan Ronan , Wan Mahmood Wan Aizad 
Published: January 2024

AbstractAimsTo evaluate changes in glycated haemoglobin (HbA1c) and sensor‐based glycaemic metrics after glucose sensor commencement in adults with T1D.MethodsWe performed a retrospective observational single‐centre study on HbA1c, and sensor‐based glycaemic data following the initiation of continuous glucose monitoring (CGM) in adults with T1D (n = 209).ResultsWe observed an overall improvement in HbA1c from 66 (59–78) mmol/mol [8.2 (7.5–9.3)%] pre‐sensor to 60 (53–71) mmol/mol [7.6 (7.0–8.6)%] on‐sensor (p < .001). The pre‐sensor HbA1c improved from 66 (57–74) mmol/mol [8.2 (7.4–8.9)%] to 62 (54–71) mmol/mol [7.8 (7.1–8.7)%] within the first year of usage to 60 (53–69) mmol/mol [7.6 (7.0–8.4)%] in the following year (n = 121, p < .001). RT‐CGM‐user had a significant improvement in HbA1c (Dexcom G6; p < .001, r = 0.33 and Guardian 3; p < .001, r = 0.59) while a non‐significant reduction was seen in FGM‐user (Libre 1; p = .279). Both MDI (p < .001, r = 0.33) and CSII group (p < .001, r = 0.41) also demonstrated significant HbA1c improvement. Patients with pre‐sensor HbA1c of ≥64 mmol/mol [8.0%] (n = 125), had attenuation of pre‐sensor HbA1c from 75 (68–83) mmol/mol [9.0 (8.4–9.7)%] to 67 (59–75) mmol/mol [8.2 (7.6–9.0)%] (p < .001, r = 0.44). Altogether, 25.8% of patients achieved the recommended HbA1c goal of ≤53 mmol/mol and 16.7% attained the recommended ≥70% time in range (3.9–10.0 mmol/L).ConclusionsOur study demonstrated that minimally invasive glucose sensor technology in adults with T1D is associated with improvement in glycaemic outcomes. However, despite significant improvements in HbA1c, achieving the recommended goals for all glycaemic metrics remained challenging.
Can right ventricular endomyocardial biopsy predict left ventricular fibrosis beforehand in dilated cardiomyopathy?
Authors: Amemiya Kisaki , Matsuyama Taka‐aki , Ishibashi‐Ueda Hatsue , Morita Yoshiaki , Matsumoto Manabu , Ohta‐Ogo Keiko , Ikeda Yoshihiko , Tsukamoto Yasumasa , Fukushima Norihide , Fukushima Satsuki , Fujita Tomoyuki , Hatakeyama Kinta 
Published: January 2024

AbstractAimsMyocardial fibrosis of the left ventricle (LV) is a prognostic factor in dilated cardiomyopathy (DCM). This study aims to evaluate whether fibrosis of right ventricular (RV) endomyocardial biopsy (EMB) can predict the degree of LV fibrosis beforehand in DCM.Methods and resultsFibrosis extent in 70 RV‐EMB specimens of DCM diagnosis was compared with that in the whole cross‐sectional LV of excised hearts in the same patients (52 explanted hearts for transplant and 18 autopsied hearts). The median interval between biopsy and excision was 4.1 (0.13–19.3) years. The fibrosis area ratio of the EMBs and excised hearts were evaluated via image analysis. The distribution of cardiovascular magnetic resonance–late gadolinium enhancement (LGE) in the intraventricular septum was classified into four quartile categories. The fibrosis area ratio in RV‐EMB correlated significantly with that in the short‐axis cut of the LV of excised hearts (r = 0.82, P < 0.0001) and with a diffuse pattern of LGE (r = 0.71, P = 0.003). In a multivariate model, after adjusting for the interval between biopsy performance and heart excision, the fibrosis area ratio in RV‐EMB was associated with that in LV‐excised heart (regression coefficient, 0.82; 95% confidence interval, 0.68–0.95; P < 0.0001).ConclusionsThe fibrosis observed in RV‐EMB positively correlated with the extent of fibrosis in the LV of excised hearts in patients with DCM. The study findings may help predict LV fibrosis, considered a prognostic factor of DCM through relatively accessible biopsy techniques.
LncRNA SNHG1 alleviates myocardial ischaemia–reperfusion injury by regulating the miR‐137‐3p/KLF4/TRPV1 axis
Authors: Tang Ruo‐Fu , Li Wen‐Jing , Lu Yun , Wang Xuan‐Xuan , Gao Su‐Yu 
Published: January 2024

AbstractAimsMyocardial ischaemia–reperfusion injury (MIRI) contributes to serious myocardial injury and even death. Long non‐coding RNAs (lncRNAs) have been reported to play pivotal roles in the occurrence and development of MIRI. Here, the detailed molecular mechanism of lncRNA SNHG1 in MIRI was explored.Methods and resultsA cell model of MIRI was established through hypoxia/reoxygenation (H/R) stimulation. Cell viability and pyroptosis were evaluated utilizing MTT, PI staining, and flow cytometry. Interleukin (IL)‐1β and IL‐18 secretion levels were examined by ELISA. The gene and protein expression were detected by RT‐qPCR and western blot, respectively. Dual luciferase reporter gene, RIP and ChIP assays were performed to analyse the molecular interactions. The results showed that lncRNA SNHG1 overexpression alleviated H/R‐induced HL‐1 cell pyroptosis (all P < 0.05). LncRNA SNHG1 promoted KLF4 expression by sponging miR‐137‐3p. miR‐137‐3p silencing alleviated H/R‐induced pyroptosis in HL‐1 cells (all P < 0.05), which was abolished by KLF4 knockdown (all P < 0.05). KLF4 activated the AKT pathway by transcriptionally activating TRPV1 in HL‐1 cells (all P < 0.05). TRPV1 knockdown reversed the alleviation of SNHG1 upregulation on H/R‐induced pyroptosis in HL‐1 cells (all P < 0.05).ConclusionsThese results showed that lncRNA SNHG1 assuaged cardiomyocyte pyroptosis during MIRI progression by regulating the KLF4/TRPV1/AKT axis through sponging miR‐137‐3p. Our findings may provide novel therapeutic targets for MIRI.
Identification of heart failure hospitalization from NHS Digital data: comparison with expert adjudication
Authors: Soltani Fardad , Bradley Joshua , Bonandi Antonio , Black Nicholas , Farrant John P. , Pailing Adam , Orsborne Christopher , Williams Simon G. , Schelbert Erik B. , Dodd Susanna , Williams Richard , Peek Niels , Schmitt Matthias , McDonagh Theresa , Miller Christopher A. 
Published: January 2024

AbstractAimsPopulation‐wide, person‐level, linked electronic health record data are increasingly used to estimate epidemiology, guide resource allocation, and identify events in clinical trials. The accuracy of data from NHS Digital (now part of NHS England) for identifying hospitalization for heart failure (HHF), a key HF standard, is not clear. This study aimed to evaluate the accuracy of NHS Digital data for identifying HHF.Methods and resultsPatients experiencing at least one HHF, as determined by NHS Digital data, and age‐ and sex‐matched patients not experiencing HHF, were identified from a prospective cohort study and underwent expert adjudication. Three code sets commonly used to identify HHF were applied to the data and compared with expert adjudication (I50: International Classification of Diseases‐10 codes beginning I50; OIS: Clinical Commissioning Groups Outcomes Indicator Set; and NICOR: National Institute for Cardiovascular Outcomes Research, used as the basis for the National Heart Failure Audit in England and Wales). Five hundred four patients underwent expert adjudication, of which 10 (2%) were adjudicated to have experienced HHF. Specificity was high across all three code sets in the first diagnosis position {I50: 96.2% [95% confidence interval (CI) 94.1–97.7%]; NICOR: 93.3% [CI 90.8–95.4%]; OIS: 95.6% [CI 93.3–97.2%]} but decreased substantially as the number of diagnosis positions expanded. Sensitivity [40.0% (CI 12.2–73.8%)] and positive predictive value (PPV) [highest with I50: 17.4% (CI 8.1–33.6%)] were low in the first diagnosis position for all coding sets. PPV was higher for the National Heart Failure Audit criteria, albeit modestly [36.4% (CI 16.6–62.2%)].ConclusionsNHS Digital data were not able to accurately identify HHF and should not be used in isolation for this purpose.
The effect of sodium–glucose cotransporter 2 inhibitors on left cardiac remodelling in heart failure with reduced ejection fraction: Systematic review and meta‐analysis
Authors: Usman Muhammad Shariq , Januzzi James L. , Anker Stefan D. , Salman Ali , Parikh Puja B. , Adamo Marianna , Filippatos Gerasimos , Khan Muhammad Shahzeb , Lala Anuradha , Verma Subodh , Metra Marco , Butler Javed 
Published: January 2024

ABSTRACTAimsThe therapeutic mechanism of sodium–glucose cotransporter 2 inhibitors (SGLT2i) on left cardiac remodelling in patients with heart failure with reduced ejection fraction (HFrEF) is not well‐established. This study meta‐analysed the impact of SGLT2i on left cardiac structure and function in patients with HFrEF.Methods and resultsOnline databases were queried up to April 2023 for trials reporting indicators of left cardiac structure and function in patients with HFrEF treated with SGLT2i. Data from studies were pooled using a random‐effects model to derive weighted mean differences (WMDs) and 95% confidence intervals (CIs). Six trials were included (n = 555). Compared with control, SGLT2i significantly improved left ventricular end‐diastolic volume (LVEDV; WMD: −17.07 ml [−23.84, −10.31]; p < 0.001), LVEDV index (WMD: −5.62 ml/m2 [−10.28, −0.97]; p = 0.02), left ventricular end‐systolic volume (LVESV; WMD: −15.63 ml [−26.15, −5.12]; p = 0.004), LVESV index (WMD: −6.90 ml/m2 [−10.68, −3.11]; p = 0.001), left ventricular ejection fraction (WMD: 2.71% [0.70, 4.72]; p = 0.008), and left atrial volume index (WMD: −2.19 ml/m2 [−4.26, −0.11]; p = 0.04) in patients with HFrEF. SGLT2i use was associated with a non‐significant trend towards a reduction in left ventricular mass index (WMD: −6.25 g/m2 [−12.79, 0.28]; p = 0.06). No significant impact on left ventricular global longitudinal strain was noted (WMD: 0.21% [−0.25, 0.67]; p = 0.38).ConclusionsSodium–glucose cotransporter 2 inhibitors improve cardiac structure and function in patients with HFrEF.
A maximally preorganized tetra‐pyridyl ligand. Rigid five‐membered chelate rings enhance selectivity for large metal ions, such as Th(IV), UO22+ and Lanthanides. A DFT and Thermodynamic study
Authors: Uritis Stuart , Thummel Randolph P. , Jones S. Bart , Lee Hee‐Seung , Hancock Robert D. 
Published: January 2024

AbstractSize‐based selectivity for metal ions based on highly preorganized five‐membered chelate rings is discussed. Metal ion complexation by the tetra‐pyridyl ligand EBIP ((8,9‐dihydro‐diquino[8,7‐b:7′,8′‐j][1,10]phenanthroline) is investigated, Formation constants (log K1) are reported for EBIP with 28 metal ions in 50 % CH3OH/H2O (v/v). The shift in size‐selectivity toward large metal ions and against small metal is demonstrated. Log K1 for the EBIP complexes shows a steady increase from La(III) to Lu(III), with a strong local maximum at Sm(III), and strong local minimum at Gd(III). This difference in log K1 between Sm(III) and Gd(III) for the tetra‐pyridyls is shown to depend largely on the level of preorganization of the ligand, being at a maximum for EBIP and a minimum for quaterpyridine. Log K1 for the Y(III) complex is invariably lower than for the similarly‐sized Ho(III) for all ligands that contain any nitrogen donors. Lower log K values for Y(III) are due to stabilization of the Ln(III) complexes with nitrogen donors by participation of the 5d orbitals, and to a lesser extent the 4 f orbitals, of the Ln(III) ions in M−L bonding. A DFT analysis of selectivity of tetra‐pyridyls for metal ions shows that Y(III) complexes should be less stable than similarly‐sized Ho(III) complexes.
Long‐term effectiveness and tolerability of ketogenic diet therapy in patients with genetic developmental and epileptic encephalopathy onset within the first 6 months of life
Authors: Song Tianyu , Deng Jie , Chen Chunhong , Wang Xiaohui , Han Tongli , Wang Xu , Fang Tie , Tian Xiaojuan , Fang Fang 
Published: January 2024

AbstractObjectiveTo investigate the effectiveness and tolerability of ketogenic diet therapy (KDT) in patients with developmental and epileptic encephalopathy (DEE) associated with genetic etiology which onset within the first 6 months of life, and to explore the association between response to KDT and genotype/clinical parameters.MethodsWe retrospectively reviewed data from patients with genetic DEE who started KDT at Beijing Children's Hospital between January 1, 2016, and December 31, 2021.ResultsA total of 32 patients were included, involving 14 pathogenic or likely pathogenic single genes, and 16 (50.0%) patients had sodium/potassium channel gene variants. The median age at onset of epilepsy was 1.0 (IQR: 0.1, 3.0) months. The median age at initiation of KDT was 10.0 (IQR: 5.3, 13.8) months and the median duration of maintenance was 14.0 (IQR: 7.0, 26.5) months, with a mean blood β‐hydroxybutyrate of 2.49 ± 0.62 mmol/L. During the maintenance period of KDT, 26 (81.3%) patients had a ≥50% reduction of seizure frequency, of which 12 (37.5%) patients achieved seizure freedom. Better responses were observed in patients with STXBP1 variants, with four out of five patients achieving seizure freedom. There were no statistically differences in the age of onset, duration of epilepsy before KDT, blood ketone values, or the presence of ion channel gene variants between the seizure‐free patients and the others. The most common adverse effects were gastrointestinal side effects, which occurred in 21 patients (65.6%), but all were mild and easily corrected. Only one patient discontinued KDT due to nephrolithiasis.SignificanceKDT is effective in treating early onset genetic DEE, and no statistically significant relationship has been found between genotype and effectiveness in this study. KDT is well tolerated in most young patients, with mild and reversible gastrointestinal side effects being the most common, but usually not the reason to discontinue KDT.Plain Language SummaryThis study evaluated the response and side effects of ketogenic diet therapy (KDT) in patients who had seizures within the first 6 months of life, and were diagnosed with genetic developmental and epileptic encephalopathy (DEE), a type of severe epilepsy with developmental delay caused by gene variants. Thirty‐two patients involving 14 gene variants who started KDT at Beijing Children's Hospital between were included. KDT was effective in treating early onset genetic DEE in this cohort, and patients with STXBP1 variants responded better; however, no statistically significant relationship was found between gene variant and response. Most young patients tolerated KDT well, with mild and reversible gastrointestinal side effects being the most common.
Online estimation of lithium battery SOC based on fractional order FOUKF‐FOMIUKF algorithm with multiple time scales
Authors: Xing Likun , Ren Hengqi , Luo Wenfei , Zhang Zhenyun , Song Yangwanhao 
Published: January 2024

AbstractAiming at the matter of poor precision in predicting the charge of lithium battery by applying conventional integer‐order models and offline parameter identification, this paper proposes a joint fractional‐order multi‐innovations unscented Kalman filter (FOUKF‐FOMIUKF) algorithm for predicting the cells' state of charge (SOC) online and uses the theory of singular‐value decomposition to tackle the issue of failure of the traceless transformation. Initially, the circuitry model of fractional order is built. The parameters of the model are recognized online by fractional‐order unscented Kalman filtering (FOUKF), and the obtained parameters are then transmitted to the method known as the fractional order multi‐innovations unscented Kalman filter (FOMIUKF) to calculate the SOC of the cell. The algorithm was validated under four working conditions such as FUDS (US Federal Urban Driving Distance), BJDST (Beijing Dynamic Stress Test), DST (Dynamic Stress Test), and US06 (Highway Driving Distance Test), respectively, and compared with the FOMIUKF, MIUKF, and FOUKF algorithms for offline identification. The conclusions demonstrate that the SOC estimated by the FOUKF‐FOMIUKF method is controlled within 0.5% of the mean absolute error under the four conditions and the root‐mean‐square error is controlled within 0.8%. It is not difficult to find that the FOUKF‐FOMIUKF algorithm estimates SOC with higher accuracy and robustness.
Bio‐based phase change material for enhanced building energy efficiency: A study of beech and thermally modified beech wood for wall structures
Authors: Grzybek Jakub , Nazari Meysam , Jebrane Mohamed , Terziev Nasko , Tippner Jan , Petutschnigg Alexander , Schnabel Thomas 
Published: January 2024

AbstractThis study investigated the impregnation of beech and thermally modified beech (TMB) with a ternary mixture of capric acid, palmitic acid, and stearic acid as a bio‐based phase change material (BPCM). Finite element method (FEM) was used to complement the experimental analysis by providing new insights into computational methods for simulating the behavior of BPCMs in untreated and TMB. The analyzed specimens namely beech and TMB were impregnated with BPCM; the TMB achieved 54% weight percentage gain (WPG) while untreated beech got 37%. Accordingly, a greater increase in the latent heat was obtained for TMB up to 90 J/g, while for untreated beech with BPCM up to 75 J/g. Impregnated specimens absorbed less moisture at relative humidity of air above 50%, likely caused by the high uptake and hydrophobic nature of the BPCM. The study highlights the research gap in performing mathematical simulations on wood samples with BPCM using material thermal properties derived from differential scanning calorimetry or T‐History analysis. It shows that the direct use of these values for simulations leads to unacceptable outputs that result in high errors. The root mean square error for untreated and TMB samples impregnated with BPCM was in the range from 1.06 to 3.1 while that for untreated samples was in the range from 0.57 to 0.87, indicating that the main challenge in simulating and characterizing the samples is due to the interaction of the phase change material with the wood structure.
Density forecast combinations: The real‐time dimension
Authors: McAdam Peter , Warne Anders 
Published: January 2024

AbstractEuro area real‐time density forecasts from three dynamic stochastic general equilibrium (DSGE) and three Bayesian vector autoregression (BVAR) models are compared with six combination methods over the sample 2001Q1–2019Q4. The terms information and observation lag are introduced to distinguish time shifts between data vintages and actuals used to compute model weights and compare the forecast, respectively. Bounds for finite mixture combinations are presented, allowing for benchmarking them given the models. Empirically, combinations with limited weight variation often improve upon the individual models for the output and the joint forecasts with inflation. This reflects overconfident BVAR forecasts before the Great Recession. For inflation, a BVAR model typically performs best.
Association of dietary inflammatory index with constipation: Evidence from the National Health and Nutrition Examination Survey
Authors: Wang Bo , Liu Chunxiang , Guo Zheng , Li Rui , Wang Yuchao , Dong Caixia , Sun Daqing 
Published: January 2024

AbstractThe association of dietary inflammatory index (DII) with constipation has not been well studied in general population. Therefore, the aim of this cross‐sectional study was to investigate whether DII is associated with constipation in a large representative sample of the US population. Data were obtained from the 2005–2010 National Health and Nutrition Examination Survey (NHANES). A total of 12,308 participants aged ≥20 years were included in the analysis. DII was calculated based on a single 24‐h dietary recall, and constipation was defined as having fewer than three bowel movements per week by the questionnaire on bowel health. Logistic regression analysis demonstrated a significant positive association between DII score and constipation, with each unit increase in DII score associated with a 20% increase in constipation risk (95% CI: 1.13–1.28). Subgroup analysis revealed high odds ratios (ORs) among individuals classified as “Other Race” (OR: 1.42, 95% CI: 1.12–1.80) and “Non‐Hispanic White” (OR: 1.31, 95% CI: 1.12–1.54). In addition, RCS analysis indicated a nonlinear relationship between DII and constipation among individuals with a BMI less than 25 (OR: 1.17, 95% CI: 1.07–1.28), while the overall trend remained positive correlation (OR: 1.20, 95% CI: 1.10–1.31). Briefly, our study suggests that there may be a link between DII and constipation, which has implications for the development of dietary interventions aimed at preventing and managing constipation. However, this association was complex and variable depending on individual factors such as BMI and racial background and needed to establish longitudinal studies to confirm the underlying mechanisms between DII and constipation.