bluuebunny/crossref_metadata_2025_split huggingface dataset:
Accelerated Corneal Cross-linking in Pediatric Patients with Progressive Keratoconus: 12-Month Follow-up Results
Authors: Dervişoğulları S , Pelit A 
Published: February 2024

ABSTRACT

Purpose:
To evaluate effectiveness and safety of accelerated corneal cross-linking (CXL) in the treatment of keratoconus in pediatric patients.

Setting:
Tertiary care hospital.

Design:
Retrospective observational study.

Methods:
In this study, case series of patients 18 years old or younger with progressive keratoconus who underwent accelerated CXL were observed. All consecutive patients underwent accelerated CXL with setting of 9 mW/cm2 for 10-minute Ultraviolet-A radiation, corresponding to a total dose of 5.4 J/cm2. Preoperative and 12-month postoperative data including uncorrected distance visual acuity (UDVA), best-corrected distance visual acuity (BDVA), keratometry (K) measurements, mean spherical, and cylindrical refraction were evaluated.

Results:
The group consisted of 28 eyes from 14 patients (10 males and 4 females). Mean age of the patients was 16.9 years (11-18 years). UDVA did not change significantly from 0.71 ± 0.54 to 0.65 ± 0.43 logMAR (P = 0.41). BDVA improved significantly from 0.30 ± 0.35 to 0.21 ± 0.34 (P = 0.006). The steep K-value decreased from 48.4 ± 4.3 to 48.0 ± 4.6 diopters, but there was no significant change in steep K-value (P = 0.35). There was no significant change in flat and mean K-value (P > 0.05). Mean spherical and cylindrical refraction were not significantly altered (P > 0.05). One patient with vernal keratoconjunctivitis showed sterile peripheral corneal infiltrates. Patient was treated with topical corticosteroids, antibiotics, and artificial tears.

Conclusion:
The findings revealed that accelerated CXL is an effective and safe procedure that halts the progression of keratoconus in pediatric patients.
Comparing Hearing Loss in Children with Adults Living with Sickle Cell Disease and Sickle Cell Traits
Authors: Ibekwe TS , Rogers C , Ramma L 
Published: February 2024

ABSTRACT

Background:
Hearing loss is a neurological sequelae associated with sickle cell disease (SCD) and probably sickle cell trait (SCT) in children and adults but remains understudied.

Aim:
This study aimed to compare the hearing impairment among children and adults living with SCD or SCT.

Methods:
A comparative cross-sectional study conducted in four departments with SCD outpatient clinic in a tertiary hospital in Nigeria. Participants with Sickle cell disease (HbSS) and Sickle cell trait (HbAS) (cohort) and HbAA (control) had comprehensive ear and hearing assessments for sensorineural hearing loss. Audiometric results were categorized according to WHO classifications and data analysed with Statistical Analysis System (SAS 9.4).

Results:
A total of 212 participants (106 cohort and control, respectively), aged 6 months to 55 years, were enrolled. Of these, 35% of children with SCD and 25% with SCT had hearing impairment, while 30% of adults with SCD, 36.1% with SCT, and 11% with HbAA had hearing impairment. There was asymmetry in the hearing impairment, with the left ear more affected in children and the right ear in adults. The odds ratio (OD) of hearing impairment was higher in HbSS (2.48 (95% confidence interval (CI):1.51–4.14); P = 0.0004) and HbAS (2.28 (95% CI: 1.1–4.58); P = 0.02) participants compared with HbAA but was not statistically significant when adjusted for frequency of hospitalization, crises, blood transfusion and routine drugs in HbAS (P = 0.49) unlike HbSS (P = 0.03).

Conclusion:
The prevalence of hearing loss among children and adults with SCD is higher than in those with HbA genotype. The frequency of hospitalization, crises, blood transfusion and taking routine drugs may influence hearing impairment in SCT but may not in SCD.
Assessment of Incidence, Management and Contributory Factors of Root Canal Instrument Separation in an Endodontics Post- Graduate Program: A Retrospective Clinical Study
Authors: Alamoudi RA , Alfarran A , Alnamnakani B , Howait M , Alghamdi NS , Ain TS 
Published: February 2024

ABSTRACT

Background:
The successful outcome of nonsurgical root canal treatment (NS-RCT) is largely dependent on the technical quality of the procedure.

Objective:
To investigate the incidence of separated instruments in endodontic postgraduate clinics between January 2018 and December 2021, and to determine the potential contributory factors that increase the risk of instrument separation.

Materials and Methods:
A retrospective observational study was conducted in the Department of Endodontics, Faculty of Dentistry, King Abdulaziz University, Jeddah, Saudi Arabia. Data was collected to determine the incidence of separated instruments and their associated variables. Seven variables were analyzed separately: nonsurgical initial or retreatment case, tooth type, tooth arch, tooth location, canal type, root curvature, level of fracture, and file type.

Results:
A total of 3150 cases were treated, of which 108 cases had separated instruments. The overall incidence of instrument separation was 3.4% while 53.7% of separated instruments occurred in the mandibular molars, followed by 42.6% in the maxillary molars. The highest frequency of instrument separation was recorded in the mesiobuccal canal (35.2%). The level of separation was found to be statistically significant in relation to the management (P < .001).

Conclusion:
Nickel-titanium instruments tend to separate more inside the root canal system than stainless steel instruments. However, under the limitation of this study, the incidence of instrument separation is still quite low, even with postgraduate endodontic residents with limited experience.
Assessment of Optic Nerve Sheath Diameter in Patients Undergoing Endoscopic Retrograde Cholangiopancreatography: A Prospective, Randomized, Controlled Double-Blinded Comparison of Propofol and Ketofol Anesthesia
Authors: Demir M , Balkiz Soyal Ö , Aytaç BG 
Published: February 2024

ABSTRACT

Background:
ERCP is an endoscopic procedure for the diagnosis and treatment of biliopancreatic system diseases. An increase in intra-abdominal pressure due to the insufflation of air to the intestinal lumen may be transmitted to ICP through the course of ERCP. In this prospective, randomized, controlled double-blinded study, we aimed to assess the ICP change using ultrasonography measurement of ONSD in patients undergoing ERCP comparing the effects of propofol and ketofol anesthesia.

Material/Methods:
One hundred and nine patients undergoing ERCP under propofol or ketofol anesthesia were enrolled in the study. Ultrasonography measurement of ONSD was performed before (T0) and immediately after induction of anesthesia (T1), during sphincterotomy (T2), at the end of procedure (T3), and after the patient is fully awake (T4).

Results:
Comparison of ONSD values and ONSD alteration between groups showed no statistically significant difference (P > 0.05). Both groups showed significantly greater changes from T0 to T2 compared with values from T0 to T1, T3, and T4, respectively (P = 0,000). T0 to T3 alteration was also significantly greater than T0 to T1 and T4 change in both groups (P = 0,000).

Conclusions:
ERCP procedure increases intracranial pressure most prominently during sphincterotomy both under propofol or ketofol anesthesia. Further studies are needed to investigate the impact of this phenomenon on adverse clinical outcomes.
IMPLEMETASIKAN NILAI-NILAI PENDIDIKAN AGAMA ISLAM PADA KOMUNITAS KELUARGA MUALAF TOBELO KABUPATEN HALMAHERA UTARA
Authors: Minabari Khalid Hasan , Miradj Safri , Naemuddin Rusdi , Rachim Zaitun A 
Published: February 2024

Berbicara tentang Pendidikan Islam tentunya tidak lepas dari bagaimana pencapaian pendidikan untuk memajukan Islam dan mencapai cita-cita masyarakat Islam secara umumnya yaitu “Rahmatan lil ‘alamin”. Berbagai asumsi pendidikan telah dipilih dan di adopsi oleh seseorang, sekelompok orang, atau lembaga pendidikan akan berfungsi memberikan dasar rujukan konseptual dalam rangka pendidikan yang dilaksanakannya. Secara umum, dapat dikatakan bahwa falsafah pendidikan adalah memberikan dasar pijakan atau titik tolak bagi seseorang, sekelompok orang atau lembaga dalam rangka pembinaan keluarga berdasakan pada nilai-nilai Islam. Penelitian ini mencoba melihat aspek nilai-nilai dalam pendidikan islam yang yang ditanamkan pada komunitas mualaf ini dalam mendidik anak-anaknya. Dari latar belakang yang dikemukakan, maka peneliti dapat merumuskan permasalahanya dalam penelitian ini sebagai berikut:Bagaimana uapaya mengimplementasikan nilai-nilai Pendidikan islam dalampada komunitas mualaf tobelo? Upaya yang dilakukan oleh kementerian agama Halmahera Utara dalam menananmkan Pendidikan islam dalam keluarga mualaf untuk membentuk keluarga ?. Jenis pendekatan studi kasus ini merupakan jenis pendekatan yangdigunakan untuk menyelidiki dan memahami sebuah kejadian atau masalah yang telahterjadi dengan mengumpulkan berbagai macam informasi yang kemudian diolah untukmendapatkan sebuah solusi agar masalah yang diungkap dapat terselesaikan.Lokasi yang akan menjadi tempat penelitian yaitu Tobelo Kabupaten Halmahera Utara Penelitian ini di rencanakan dilaksanakan pada bulan Maret sampai Juni 2023. Lokasi yang penelitian ini dipilih karena berdekatan dengan tempetat tinggal peneliti, sehingga mempermudah peneliti dalam pengambilan data. Penerpan pendidikanAgamapadakeluargamualafdiTobelo – Kab. Halmahera Utara, orang tua mualaf mengajarkan pendidikanagama terutama dalam hal ibadah, dengan cara mengajak shalat berjamaa‟ahbersamamembimbinganak-anakuntukshalatberjama‟ahdimasjidmenyekolahkan anak ke Lembaga Pendidikan Islam, mendatangkan guru mengaji kerumah, sertamengajikananak-anak ke TPQ.Orangtuamualafmendidikanakmenggunakan metodeketeladanan, pembiasaan, nasehat, reward (penghargaan) dan hukuman.
Discovery of fecal microbial signatures in patients with ankylosing spondylitis
Authors: You Yuquan , Zhang Wei , Cai Meimei , Guo Qingxin , Wang Jiawen , Cai Yaping , Lin Junsheng 
Published: February 2024

Objectives: This study aimed to investigate the characteristics of the gut microbiota in Chinese patients with ankylosing spondylitis (AS) and healthy controls in Quanzhou aiming to explore the correlation between microbiome changes and AS activities.
Patients and methods: In this study, high-throughput sequencing of the gene of 16S ribosomal RNA (16S rRNA) in fecal samples from 40 AS patients and 40 healthy controls, for a total of 80 participants (70 males, 10 females; mean age 33.7±10.7 years; range, 15 to 58 years), was conducted between January 2018 and January 2019. Alpha and beta diversity were analyzed using the QIIME (Quantitative Insights Into Microbial Ecology) software, and differences were analyzed using Student’s t-test, linear discriminant analysis coupled with effect size and Metastats. Finally, a correlation network was constructed using Pearson’s analysis.
Results: The alpha index values of the AS group were not significantly different from those of the control group. At the genus level, eight genera, Ruminiclostridium_9, Fusicatenibacter, Adlercreutzia, CAG-56, Intestinimonas, Lachnospira, Bacteroides, and Pseudoflavonifractor, were significantly enriched in patients with AS, whereas the abundance of uncultured_bacterium_f_Saccharimonadaceae, Prevotella_7, uncultured_bacterium_f_ Enterobacteriaceae, Cronobacter, Prevotellaceae_NK3B31_group, and Weissella were significantly decreased in patients with AS. In addition, diseaserelated gut microbial communities were detected in patients with AS.
Conclusion: We found differences in the gut microbiome between the patients with AS and controls and identified potential disease activity-related bacterial communities.
Readmission reasons of pediatric patients diagnosed with multisystem inflammatory syndrome after discharge
Authors: Cem Ela , Kıymet Elif , Böncüoğlu Elif , Şahinkaya Şahika , Yılmaz Çelebi Miray , Gülderen Mustafa , Akaslan Kara Aybüke , Meşe Timur , Ağin Hasan , Bayram Nuri , Devrim İlker 
Published: February 2024

Objectives: There is no clear information in the literature about causes of reactivation of multisystem inflammatory syndrome in children (MIS-C) or indications for readmissions for MIS-C after discharge; as a result, the conditions that may develop after infection in children with MIS-C were discussed, and the reasons for hospitalization were screened.
Patients and methods: This single-center retrospective study was conducted with 95 patients (65 males, 30 females; mean age: 92.8±55.5 months; range, 5 to 17 months) between November 11, 2020, and December 30, 2021. Children who were rehospitalized in the study center after their discharge with the diagnosis of MIS-C were included in the study, and the indications for readmissions were evaluated.
Results: During the study period, six (6.3%) patients (4 males, 2 females; median age: 114.5 months [interquartile range: 122 months]) had to be rehospitalized. Four of these patients had an underlying disease, while the other two were previously healthy children. Fever was the most common reason for readmissions in half of the patients, while the remaining patients were readmitted with the indications of myocarditis, pneumonia, and posttraumatic pain syndrome.
Conclusion: Although no evidence for the reactivation of MIS-C was detected in patients in the literature, it should also be emphasized that close follow-up of these patients is a must, considering possible cardiac complications.
The impact of COVID-19 on clinical course and treatment among patients with juvenile systemic sclerosis
Authors: Adrovic Amra , Yıldız Mehmet , Haşlak Fatih , Şahin Sezgin , Köker Oya , Günalp Aybüke , Barut Kenan , Kasapçopur Özgür 
Published: February 2024

Objectives: This study aimed to explore the influence of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) pandemic among patients with juvenile systemic sclerosis (JSS).
Patients and methods: Twenty-seven patients (22 females, 5 males; mean age: 20 years; range, 17 to 22 years) diagnosed with JSS and followed up at the department of pediatric rheumatology were included in the cross-sectional study. A web-based survey was performed by focusing on patients’ complaints, accessibility to health care, and compliance with routine treatment from January 1, 2021, to January 10, 2021.
Results: Five (18.5%) patients had deterioration of the disease, while six (22.2%) patients reported irregular usage of their routine scleroderma treatment during the last six months. Nine (33.3%) patients had missed their routine clinic control since the proclamation of the SARS-CoV-2 pandemic. Seven (25.9%) patients had household contact with coronavirus disease 2019 (COVID-19). Four (14.8%) patients were diagnosed with COVID-19, and only one (3.7%) was hospitalized. Nine patients were under biological treatment (tocilizumab); however, only one of them was diagnosed with COVID-19.
Conclusion: The COVID-19 pandemic has not significantly disrupted the medical care of JSS patients. Telemedicine could be an acceptable option for JSS patients disenabled to come to the hospital.
Evaluation of peripheral nerve involvements in patients with familial Mediterranean fever
Authors: Karabacak Atak , İnan Rahşan , Şen Nesrin 
Published: February 2024

Objectives: The aim of this study was to evaluate possible peripheral and autonomic nerve involvement in familial Mediterranean fever (FMF) patients with nerve conduction studies, sympathetic skin response (SSR) and RR interval variability (RRIV).
Patients and methods: The comparative case series was conducted with 76 participants between November 2017 and December 2018. Forty-six FMF patients, [12 with amyloidosis (5 males, 7 females; mean age: 44.7±13.9 years) and 34 without amyloidosis (14 males, 20 females; mean age: 35.9±8.7 years)], and 30 healthy volunteers (11 males, 19 females; mean age: 38.4±10 years) were included in this study. Nerve conduction parameters, SSR latency and amplitude from palmar and plantar responses, and RRIV at rest and deep breathing were studied in all the subjects. Neuropathic symptoms of the patient group were evaluated using the survey of autonomic symptoms scale and the neuropathy disability score.
Results: Nerve conduction studies of the patient group revealed polyneuropathy in seven (15.21%) patients and carpal tunnel syndrome in six (13.04%) patients. The mean amplitudes of SSR measured from the soles were significantly lower than the control group (p=0.041). The mean values of RRIV during rest and hyperventilation were lower in the patient group compared to the control group, but no statistically significant difference was found (p=0.484, p=0.341).
Conclusion: We detected that the prevalence of carpal tunnel syndrome in our patient population (13.04%) was higher than in the general population. Most of the changes in the range of parameters of SSR and RRIV determined in the patient group did not reach statistical significance, suggesting subclinical dysautonomia in FMF patients.
O IMPACTO DAS MÍDIAS DIGITAIS NA EDUCAÇÃO
Authors: Dias Artenizia Leonel , Silva Claudia Kreuzberg da , Rios Ferdinando Sampaio , Oliveira Ricardo Furtado de , Santos Sonia Araújo dos 
Published: February 2024

O presente trabalho tem como objetivo trazer uma reflexão bibliográfica acerca do impacto das mídias digitais na educação. É de conhecimento de todos que as mídias digitais facilitam muito o cotidiano da sociedade, especialmente a comunicação, o trabalho e a área educacional. Para isso, discutiu-se sobre a utilização das mídias digitais na criação de conteúdos educacionais, a utilização de multimídia e hipermídia na educação e realidade da educação atual. Assim, a problemática foi como a educação tem utilizado as mídias digitais para desenvolver conteúdos pedagógicos e: quais possibilidades essas tecnologias oferece no contexto educacional? A metodologia aplicada foi de pesquisa bibliográfica com material encontrado em repositórios acadêmicos como Google Acadêmico e ScieLO com a utilização de 9 referências com relevância para a temática em questão. Os possíveis resultados foram que as mídias digitais têm sido indispensáveis para o processo de ensino e aprendizagem dos alunos, mostrando que a utilização adequada dessas ferramentas possibilita o desenvolvimento educacional.
Pengaruh Green Marketing terhadap Green Buying Behavior Melalui Environmental Knowledge: Studi pada Unilever Indonesia
Authors: Alrizki Gilang , Kusuma Dewi Citra 
Published: February 2024

In resolving the issues looked by the world and the sustainability of life, including climate change, a shared commitment has been formulated in the form of the Sustainable Development Goals (SDGs). One of the companies in Indonesia contributing to the SDGs is Unilever. Unilever has been focused on launching the Unilever Sustainable Living Plan (USLP) since 2010. The reason for this study is to decide the impact of Green Promotion on Green Purchasing Behavior through Ecological Information on Unilever products in Indonesia. Eco-Labeling, Green Advertising, and Green Branding are the three dimensions used in Ali's previous research (2021) to describe environmentally friendly marketing strategies. Eco-Marking is an external confirmation carried out by an organization, taking actions to preserve the climate, and is also included in the eco-label category. Environmental-friendly promotion intends to urge shoppers to utilize harmless to the ecosystem items fully intent on working on ecological security. In the concept of the green marketing, labeling becomes the core of the advertising system in the contemporary business world. This exploration employs a quantitative strategy through various tests, such as legitimacy tests, dependency tests, model fairness tests, speculation tests with intervention factors, and descriptive tests. Based on the results of the mediation analysis, the environmental knowledge variable doesn't intercede the connection between the eco-labeling variable and green buying behavior. The environmental knowledge variable completely intercede the connection between the green advertising variable and green buying behavior. The environmental knowledge variable completely intercede the connection between the green branding variable and green buying behavior.
Risk factors affecting oncological outcomes of surgical resections for middle and lower rectal cancer
Authors: Tırnova İsmail , Işık Özgen , Tuncay Yılmazlar Ahmet 
Published: February 2024

Objective: In our study, it was aimed to evaluate the factors affecting oncological outcomes in resections for rectal cancer.
Material and Methods: Between January 2010 and December 2014, patients with rectal tumors were analyzed retrospectively. Demographic and pathological data and oncological outcomes were analyzed as disease-free survival, overall survival, and local recurrence.
Results: A total of 158 patients’ data were obtained. Median age was 60 (22-83). Fifty-three patients were older than 65 years of age (138). Ninety-five (60%) patients were males, and 63 (40%) were females. Eighty patients (50.4%) had middle rectal, and 78 (49.6) patients had lower rectal cancer. There was no effect of tumor localization on oncological outcomes. Univariate analyses revealed the effects of age (p= 0.003), operation type (p< 0.001), nodal status (p< 0.001), malignant lymph node ratio (p< 0.001), stage of the disease (p< 0.001), distal resection margin (p= 0.047), perineural invasion (p< 0.001), lymphatic invasion (p< 0.001), venous-vascular invasion (p= 0.025), local recurrence (p< 0.001) and distant metastasis (p< 0.001) on overall survival rates. Univariate analyses revealed the effects of nodal status (p= 0.007), malignant lymph node ratio (p= 0.005), stage of the disease (p= 0.008), perineural invasion (p= 0.004) and venous-vascular invasion (p< 0.001) on disease-free survival rates. Univariate analyses revealed the effects of anastomotic leak (p= 0.015) and venous-vascular invasion (p= 0.001) on local recurrence rates.
Conclusion: Older age, advanced nodal status, and distant metastasis were detected as independent risk factors for overall survival. Perineural and venous-vascular invasion were detected as independent risk factors for disease-free survival. Lastly, anastomotic leak and venous-vascular invasion were detected as independent risk factors for local recurrence.
Nilai-Nilai Pendidikan Agama Hindu Pada Upacara Usabha Gede Di Pura Segara Bulakan Desa Datah Kecamatan Abang Kabupaten Karangasem
Authors: Erlia Ayu Widha 
Published: February 2024

Penelitian ini bertujuan untuk mendeskripsikan penerapan model pembelajaran kooperatif tipe two stay two stray untuk meningkatkan keaktifan belajar Pendidikan Agama Hindu kelas IV Sekolah Dasar Negeri 2 Purwakerthi. Rancangan yang digunakan adalah PTK dengan subjek sebanyak 25 orang. Metode pengumpulan data yang digunakan yaitu metode observasi untuk mendapatkan data keaktifan siswa. Hasil penelitian ini menunjukkan bahwa penerapan model pembelajaran kooperatif tipe two stay two stray dalam pembelajaran Pendidikan Agama Hindu dapat meningkatkan keaktifan belajar Pendidikan Agama Hindu. Rata-rata skor keaktifan belajar siswa dari 18,81 pada awal siklus 1 meningkat menjadi 28,06 pada akhir siklus II (tergolong sangat aktif). Jadi dapat disimpulkan dengan penerapan model pembelajaran kooperatif tipe two stay two stray , keaktifan belajar meningkat sebesar 9,25 Berdasarkan hasil penelitian tersebut, dapat diajukan saran kepada pihak-pihak terkait seperti: kepada para pendidik di Sekolah Dasar Negeri 2 Purwakerthi khususnya guru Agama Hindu, untuk menerapkan model pembelajaran kooperatif tipe two stay two stray dalam pembelajaran Agama Hindu