bluuebunny/crossref_metadata_2025_split huggingface dataset:
Wavelike Structures of E‐Region Irregularities Observed by All‐Sky Radar at Low Latitude
Authors: Sun Wenjie , Li Guozhu , Han Chenying , Hu Lianhuan , Li Yi , Xie Haiyong , Zhao Xiukuan , Ning Baiqi , Liu Libo 
Published: October 2023

AbstractWe report for the first time a case of wavelike structures of E‐region irregularities observed by an all‐sky radar at Ledong (18.44°N, 108.97°E), China. The wavelike structures covered up to 250 km zonally, fluctuated in the vertical and horizontal planes, and were observed in the directions perpendicular and significantly off‐perpendicular to the geomagnetic field. The wavelength, and vertical and horizontal oscillating amplitudes were estimated at about 20–70, 5, and 2 km, respectively. Eventually, the large‐scale wavelike structure broke into spatially separated small‐scale patches and disappeared. The case provides observational evidence for the wave modulating sporadic E (Es) mechanism, which suggests that the wavelike structures of E‐region irregularity were primarily generated by wind shears and modulated by gravity waves. The wavelike structure was possibly an intermediate state between the continuous‐type and quasiperiodic‐type E‐region irregularities. The mechanism responsible for the echoing structure observed in off‐perpendicular directions is unclear. The possible contributions from refraction and reflection by intense Es layer/structure were discussed.
p63: a crucial player in epithelial stemness regulation
Authors: Li Yanan , Giovannini Sara , Wang Tingting , Fang Jiankai , Li Peishan , Shao Changshun , Wang Ying ,   TOR centre, Agostini Massimiliano , Bove Pierluigi , Mauriello Alessandro , Novelli Giuseppe , Piacentini Mauro , Rovella Valentina , Scimeca Manuel , Sica Giuseppe , Sun Qiang , Tisone Giuseppe , Shi Yufang , Candi Eleonora , Melino Gerry , Bernassola Francesca 
Published: October 2023

AbstractEpithelial tissue homeostasis is closely associated with the self-renewal and differentiation behaviors of epithelial stem cells (ESCs). p63, a well-known marker of ESCs, is an indispensable factor for their biological activities during epithelial development. The diversity of p63 isoforms expressed in distinct tissues allows this transcription factor to have a wide array of effects. p63 coordinates the transcription of genes involved in cell survival, stem cell self-renewal, migration, differentiation, and epithelial-to-mesenchymal transition. Through the regulation of these biological processes, p63 contributes to, not only normal epithelial development, but also epithelium-derived cancer pathogenesis. In this review, we provide an overview of the role of p63 in epithelial stemness regulation, including self-renewal, differentiation, proliferation, and senescence. We describe the differential expression of TAp63 and ΔNp63 isoforms and their distinct functional activities in normal epithelial tissues and in epithelium-derived tumors. Furthermore, we summarize the signaling cascades modulating the TAp63 and ΔNp63 isoforms as well as their downstream pathways in stemness regulation.
Predictors of outcomes in hematopoietic cell transplantation for Fanconi anemia
Authors: Cancio Maria , Troullioud Lucas Alexandre G. , Bierings Marc , Klein Elizabeth , de Witte Moniek A. , Smiers Frans J. , Bresters Dorine , Boelens Jaap Jan , Smetsers Stephanie E. 
Published: October 2023

AbstractAllogeneic hematopoietic cell transplantation (HCT) remains the only cure for the hematologic manifestations of Fanconi anemia (FA). We performed retrospective predictor analyses for HCT outcomes in FA for pediatric and young adult patients transplanted between 2007 and 2020 across three large referral institutions. Eighty-nine patients, 70 with bone marrow failure +/− cytogenetic abnormalities, 19 with MDS/AML, were included. Five-year overall survival (OS) was 83.2% and event-free survival (EFS) was 74%. Age ≥19, HLA mismatch and year of HCT were multivariable predictors (MVPs) for OS, EFS and treatment-related mortality (TRM). In the pediatric group, TCD was a borderline MVP (P = 0.059) with 5-year OS of 73.0% in TCD vs. 100% for T-replete HCT. The cumulative incidence of day 100 grade II-IV aGvHD and 5-year cGvHD were 5.6% and 4.6%, respectively. Relapse in the MDS/AML subgroup occurred in 4 patients (16%). Graft failure was seen in 9 patients (TCD 6/37 [16%]; T-replete 3/52 [5.7%]). Six patients developed malignancy after HCT. Survival chances after HCT for FA are excellent and associated with high engrafted survival and low toxicity. Age ≥19, HLA mismatch, year of transplant and ‘TCD in the <19 years group’ (although borderline) were found to be negative predictors for survival.
Specific measures for data-intensive health research without consent: a systematic review of soft law instruments and academic literature
Authors: Smit Julie-Anne R. , Mostert Menno , van der Graaf Rieke , Grobbee Diederick E. , van Delden Johannes J. M. 
Published: October 2023

AbstractIt is a common misunderstanding of current European data protection law that when consent is not being used as lawful basis, the processing of personal data is prohibited. Article 9(2)(j) of the European General Data Protection Regulation (GDPR) permits Member States to establish a legal basis in national law that allows for the processing of personal data for scientific research purposes without consent. However, the European legislator has formulated this “research exemption” as an opening clause, rendering the GDPR not specific as to what measures exactly are required to comply with the research exemption. This may have significant implications for both the protection of personal data and the advancement of data-intensive health research. We performed a systematic review of relevant soft law instruments and academic literature to identify what measures are mentioned in those documents. Our analysis resulted in the identification of four overarching themes of suggested measures: organizational measures; technical measures; oversight and review mechanisms; and public engagement and participation. Some of the suggested measures do not substantially contribute to the clarification of the GDPR’s “suitable and specific measures” requirement because they remain vague or broad in nature and encompass all types of data processing. However, the themes oversight and review mechanisms and public engagement and participation provide valuable insights which can be put to practice. Nevertheless, further clarification of the measures and safeguards that should be installed when invoking the research exemption remains necessary.
Jupiter-like planets might be common in a low-density environment
Authors: Gratton Raffaele , Mesa Dino , Bonavita Mariangela , Zurlo Alice , Marino Sebastian , Kervella Pierre , Desidera Silvano , D’Orazi Valentina , Rigliaco Elisabetta 
Published: October 2023

AbstractRadial velocity surveys suggest that the Solar System may be unusual and that Jupiter-like planets have a frequency < 20% around solar-type stars. However, they may be much more common in one of the closest associations in the solar neighbourhood. Young moving stellar groups are the best targets for direct imaging of exoplanets and four massive Jupiter-like planets have been already discovered in the nearby young β Pic Moving Group (BPMG) via high-contrast imaging, and four others were suggested via high precision astrometry by the European Space Agency’s Gaia satellite. Here we analyze 30 stars in BPMG and show that 20 of them might potentially host a Jupiter-like planet as their orbits would be stable. Considering incompleteness in observations, our results suggest that Jupiter-like planets may be more common than previously found. The next Gaia data release will likely confirm our prediction.
The admixed brushtail possum genome reveals invasion history in New Zealand and novel imprinted genes
Authors: Bond Donna M. , Ortega-Recalde Oscar , Laird Melanie K. , Hayakawa Takashi , Richardson Kyle S. , Reese Finlay.C. B. , Kyle Bruce , McIsaac-Williams Brooke E. , Robertson Bruce C. , van Heezik Yolanda , Adams Amy L. , Chang Wei-Shan , Haase Bettina , Mountcastle Jacquelyn , Driller Maximilian , Collins Joanna , Howe Kerstin , Go Yasuhiro , Thibaud-Nissen Francoise , Lister Nicholas C. , Waters Paul D. , Fedrigo Olivier , Jarvis Erich D. , Gemmell Neil J. , Alexander Alana , Hore Timothy A. 
Published: October 2023

AbstractCombining genome assembly with population and functional genomics can provide valuable insights to development and evolution, as well as tools for species management. Here, we present a chromosome-level genome assembly of the common brushtail possum (Trichosurus vulpecula), a model marsupial threatened in parts of their native range in Australia, but also a major introduced pest in New Zealand. Functional genomics reveals post-natal activation of chemosensory and metabolic genes, reflecting unique adaptations to altricial birth and delayed weaning, a hallmark of marsupial development. Nuclear and mitochondrial analyses trace New Zealand possums to distinct Australian subspecies, which have subsequently hybridised. This admixture allowed phasing of parental alleles genome-wide, ultimately revealing at least four genes with imprinted, parent-specific expression not yet detected in other species (MLH1, EPM2AIP1, UBP1 and GPX7). We find that reprogramming of possum germline imprints, and the wider epigenome, is similar to eutherian mammals except onset occurs after birth. Together, this work is useful for genetic-based control and conservation of possums, and contributes to understanding of the evolution of novel mammalian epigenetic traits.
Lorentz microscopy of optical fields
Authors: Gaida John H. , Lourenço-Martins Hugo , Yalunin Sergey V. , Feist Armin , Sivis Murat , Hohage Thorsten , García de Abajo F. Javier , Ropers Claus 
Published: October 2023

AbstractIn electron microscopy, detailed insights into nanoscale optical properties of materials are gained by spontaneous inelastic scattering leading to electron-energy loss and cathodoluminescence. Stimulated scattering in the presence of external sample excitation allows for mode- and polarization-selective photon-induced near-field electron microscopy (PINEM). This process imprints a spatial phase profile inherited from the optical fields onto the wave function of the probing electrons. Here, we introduce Lorentz-PINEM for the full-field, non-invasive imaging of complex optical near fields at high spatial resolution. We use energy-filtered defocus phase-contrast imaging and iterative phase retrieval to reconstruct the phase distribution of interfering surface-bound modes on a plasmonic nanotip. Our approach is universally applicable to retrieve the spatially varying phase of nanoscale fields and topological modes.
Molecular imprinting-based indirect fluorescence detection strategy implemented on paper chip for non-fluorescent microcystin
Authors: Li Bowei , Qi Ji , Liu Feng , Zhao Rongfang , Arabi Maryam , Ostovan Abbas , Song Jinming , Wang Xiaoyan , Zhang Zhiyang , Chen Lingxin 
Published: October 2023

AbstractFluorescence analysis is a fast and sensitive method, and has great potential application in trace detection of environmental toxins. However, many important environmental toxins are non-fluorescent substances, and it is still a challenge to construct a fluorescence detection method for non-fluorescent substances. Here, by means of charge transfer effect and smart molecular imprinting technology, we report a sensitive indirect fluorescent sensing mechanism (IFSM) and microcystin (MC-RR) is selected as a model target. A molecular imprinted thin film is immobilized on the surface of zinc ferrite nanoparticles (ZnFe2O4 NPs) by using arginine, a dummy fragment of MC-RR. By implementation of IFSM on the paper-based microfluidic chip, a versatile platform for the quantitative assay of MC-RR is developed at trace level (the limit of detection of 0.43 μg/L and time of 20 min) in real water samples without any pretreatment. Importantly, the proposed IFSM can be easily modified and extended for the wide variety of species which lack direct interaction with the fluorescent substrate. This work offers the potential possibility to meet the requirements for the on-site analysis and may explore potential applications of molecularly imprinted fluorescent sensors.
Deep-LASI: deep-learning assisted, single-molecule imaging analysis of multi-color DNA origami structures
Authors: Wanninger Simon , Asadiatouei Pooyeh , Bohlen Johann , Salem Clemens-Bässem , Tinnefeld Philip , Ploetz Evelyn , Lamb Don C. 
Published: October 2023

AbstractSingle-molecule experiments have changed the way we explore the physical world, yet data analysis remains time-consuming and prone to human bias. Here, we introduce Deep-LASI (Deep-Learning Assisted Single-molecule Imaging analysis), a software suite powered by deep neural networks to rapidly analyze single-, two- and three-color single-molecule data, especially from single-molecule Förster Resonance Energy Transfer (smFRET) experiments. Deep-LASI automatically sorts recorded traces, determines FRET correction factors and classifies the state transitions of dynamic traces all in ~20–100 ms per trajectory. We benchmarked Deep-LASI using ground truth simulations as well as experimental data analyzed manually by an expert user and compared the results with a conventional Hidden Markov Model analysis. We illustrate the capabilities of the technique using a highly tunable L-shaped DNA origami structure and use Deep-LASI to perform titrations, analyze protein conformational dynamics and demonstrate its versatility for analyzing both total internal reflection fluorescence microscopy and confocal smFRET data.
ALKBH5 controls the meiosis-coupled mRNA clearance in oocytes by removing the N 6-methyladenosine methylation
Authors: Bai Long , Xiang Yu , Tang Minyue , Liu Shuangying , Chen Qingqing , Chen Qichao , Zhang Min , Wan Shan , Sang Yimiao , Li Qingfang , Wang Sisi , Li Zhekun , Song Yang , Hu Xiaoling , Mao Luna , Feng Guofang , Cui Long , Ye Yinghui , Zhu Yimin 
Published: October 2023

AbstractN6-methyladenosine (m6A) maintains maternal RNA stability in oocytes. One regulator of m6A, ALKBH5, reverses m6A deposition and is essential in RNA metabolism. However, the specific role of ALKBH5 in oocyte maturation remains elusive. Here, we show that Alkbh5 depletion causes a wide range of defects in oocyte meiosis and results in female infertility. Temporal profiling of the maternal transcriptomes revealed striking RNA accumulation in Alkbh5−/− oocytes during meiotic maturation. Analysis of m6A dynamics demonstrated that ALKBH5-mediated m6A demethylation ensures the timely degradation of maternal RNAs, which is severely disrupted following Alkbh5−/− depletion. A distinct subset of transcripts with persistent m6A peaks are recognized by the m6A reader IGF2BP2 and thus remain stabilized, resulting in impaired RNA clearance. Additionally, reducing IGF2BP2 in Alkbh5-depleted oocytes partially rescued these defects. Overall, this work identifies ALKBH5 as a key determinant of oocyte quality and unveil the facilitating role of ALKBH5-mediated m6A removal in maternal RNA decay.
Prediction of nonlayered oxide monolayers as flexible high-κ dielectrics with negative Poisson’s ratios
Authors: Hu Yue , Jiang Jingwen , Zhang Peng , Ma Zhuang , Guan Fuxin , Li Da , Qian Zhengfang , Zhang Xiuwen , Huang Pu 
Published: October 2023

AbstractDuring the last two decades, two-dimensional (2D) materials have been the focus of condensed matter physics and material science due to their promising fundamental properties and (opto-)electronic applications. However, high-κ 2D dielectrics that can be integrated within 2D devices are often missing. Here, we propose nonlayered oxide monolayers with calculated exfoliation energy as low as 0.39 J/m2 stemming from the ionic feature of the metal oxide bonds. We predict 51 easily or potentially exfoliable oxide monolayers, including metals and insulators/semiconductors, with intriguing physical properties such as ultra-high κ values, negative Poisson’s ratios and large valley spin splitting. Among them, the most promising dielectric, GeO2, exhibits an auxetic effect, a κ value of 99, and forms type-I heterostructures with MoSe2 and HfSe2, with a band offset of ~1 eV. Our study opens the way for designing nonlayered 2D oxides, offering a platform for studying the rich physics in ultra-thin oxides and their potential applications in future information technologies.
Remote inspection of adversary-controlled environments
Authors: Tobisch Johannes , Philippe Sébastien , Barak Boaz , Kaplun Gal , Zenger Christian , Glaser Alexander , Paar Christof , Rührmair Ulrich 
Published: October 2023

AbstractRemotely monitoring the location and enduring presence of valuable items in adversary-controlled environments presents significant challenges. In this article, we demonstrate a monitoring approach that leverages the gigahertz radio-wave scattering and absorption of a room and its contents, including a set of mirrors with random orientations placed inside, to remotely verify the absence of any disturbance over time. Our technique extends to large physical systems the application of physical unclonable functions for integrity protection. Its main applications are scenarios where parties are mutually distrustful and have privacy and security constraints. Examples range from the verification of nuclear arms-control treaties to the securing of currency, artwork, or data centers.
4D Optical fibers based on shape-memory polymers
Authors: Strutynski Clément , Evrard Marianne , Désévédavy Frédéric , Gadret Grégory , Jules Jean-Charles , Brachais Claire-Hélène , Kibler Bertrand , Smektala Frédéric 
Published: October 2023

AbstractAdaptative objects based on shape-memory materials are expected to significantly impact numerous technological sectors including optics and photonics. In this work, we demonstrate the manufacturing of shape-memory optical fibers from the thermal stretching of additively manufactured preforms. First, we show how standard commercially-available thermoplastics can be used to produce long continuously-structured microfilaments with shape-memory abilities. Shape recovery as well as programmability performances of such elongated objects are assessed. Next, we open the way for light-guiding multicomponent fiber architectures that are able to switch from temporary configurations back to user-defined programmed shapes. In particular, we show that distinct designs of fabricated optical fibers can maintain efficient light transmission upon completion of multiple temperature-triggered bending/straightening cycles. Such fibers are also programmed into more complex shapes including coils or near 180 ° curvatures for delivering laser light around obstacles. Finally, a shape-memory exposed-core fiber is employed in fiber evanescent wave spectroscopy experiments to optimize the performance of the sensing scheme. We strongly expect that such actuatable fibers with light-guiding abilities will trigger exciting progress of unprecedented smart devices in the areas of photonics, electronics, or robotics.
Enhanced peripheral nerve regeneration by mechano-electrical stimulation
Authors: Tai Youyi , Tonmoy Thamidul Islam , Win Shwe , Brinkley Natasha T. , Park B. Hyle , Nam Jin 
Published: October 2023

AbstractTo address limitations in current approaches for treating large peripheral nerve defects, the presented study evaluated the feasibility of functional material-mediated physical stimuli on peripheral nerve regeneration. Electrospun piezoelectric poly(vinylidene fluoride-trifluoroethylene) nanofibers were utilized to deliver mechanical actuation-activated electrical stimulation to nerve cells/tissues in a non-invasive manner. Using morphologically and piezoelectrically optimized nanofibers for neurite extension and Schwann cell maturation based on in vitro experiments, piezoelectric nerve conduits were synthesized and implanted in a rat sciatic nerve transection model to bridge a critical-sized sciatic nerve defect (15 mm). A therapeutic shockwave system was utilized to periodically activate the piezoelectric effect of the implanted nerve conduit on demand. The piezoelectric nerve conduit-mediated mechano-electrical stimulation (MES) induced enhanced peripheral nerve regeneration, resulting in full axon reconnection with myelin regeneration from the proximal to the distal ends over the critical-sized nerve gap. In comparison, a control group, in which the implanted piezoelectric conduits were not activated in vivo, failed to exhibit such nerve regeneration. In addition, at both proximal and distal ends of the implanted conduits, a decreased number of damaged myelination (ovoids), an increased number of myelinated nerves, and a larger axonal diameter were observed under the MES condition as compared to the control condition. Furthermore, unlike the control group, the MES condition exhibited a superior functional nerve recovery, assessed by walking track analysis and polarization-sensitive optical coherence tomography, demonstrating the significant potential of the piezoelectric conduit-based physical stimulation approach for the treatment of peripheral nerve injury.
Efficacy of standard operating procedures for fall protection in hospitalized patients with schizophrenia
Authors: Li Hui , Liu Caixing , Ge Zengyun , Mu Xishu , Wang Xuan , Xiu Meihong , Wang Xinfu , Li Zezhi 
Published: October 2023

AbstractFall-related injury is the most common cause of functional disability and mortality in the older population. Falls in patients with schizophrenia are one of the major concerns in psychiatric hospitals. This study aimed to examine the impact of standardized operating procedures (SOP) on falls in veterans with schizophrenia. Veterans with schizophrenia were allocated to the control group (n = 345) and to the fall protection standardized operating procedures (FP-SOP) group (n = 342). Patients in the control group were given routine nursing for falls, and patients in the FP-SOP group were intervened with FP-SOP plus routine nursing. All patients were observed for one year. The study methods comply with the Strengthening the Reporting of Observational Studies in Epidemiology (STROBE) checklist. We found a fall rate of 1.5% in the FP-SOP group and 4.6% in the control group, with a significant difference in the fall rate between the two groups. In addition, the difference in patient satisfaction between the two groups was statistically significant. Our findings suggest that FP-SOP is an effective strategy for fall prevention in psychiatric hospitals.
Inertial measurement data from loose clothing worn on the lower body during everyday activities
Authors: Jayasinghe Udeni , Hwang Faustina , Harwin William S. 
Published: October 2023

AbstractEmbedding sensors into clothing is promising as a way for people to wear multiple sensors easily, for applications such as long-term activity monitoring. To our knowledge, this is the first published dataset collected from sensors in loose clothing. 6 Inertial Measurement Units (IMUs) were configured as a ‘sensor string’ and attached to casual trousers such that there were three sensors on each leg near the waist, thigh, and ankle/lower-shank. Participants also wore an Actigraph accelerometer on their dominant wrist. The dataset consists of 15 participant-days worth of data collected from 5 healthy adults (age range: 28–48 years, 3 males and 2 females). Each participant wore the clothes with sensors for between 1 and 4 days for 5–8 hours per day. Each day, data were collected while participants completed a fixed circuit of activities (with a video ground truth) as well as during free day-to-day activities (with a diary). This dataset can be used to analyse human movements, transitional movements, and postural changes based on a range of features.