bluuebunny/crossref_metadata_2025_split huggingface dataset:
Pedagogical Design as a Tool to Increase Students’ Learning Motivation During Distance Learning
Authors: Beisembayeva Altynai , Ibrayeva Kamarsulu , Yerezhepov Talgat , Urazaliyeva Moldir , Sultangaliyeva Elmira 
Published: December 2023

AbstractThe introduction and spread of distance learning imply a shift in approaches and methods of its organisation. This affects the methods and goals of the interaction of subjects of educational activity, including their motivation. That is why the question regarding the analysis of educational components and models aimed at increasing the motivation of education applicants is relevant. Based on this, the purpose of the study was formed, which was to investigate pedagogical design in the context of a means to increase students’ interest in the educational process. As a result, the concept of “pedagogical design” was defined in the context of a modern approach to the implementation of educational and professional training of applicants for education. The features of the establishment of the educational environment based on common goals of learning tasks are considered. The study characterised the basics of pedagogical design, namely, the effective formation of goals, scientific, accessibility, self-organisation, and differentiation of the educational process, providing conditions for the development of a person’s experience.
Inclusive rice seed business: Performance and sustainability
Authors: Prasetyo Teguh , Arianti Forita Dyah , Jauhari Sodiq , Setiani Cahyati , Cempaka Intan Gilang , Pertiwi Miranti Dian , Wulanjari Munir Eti , Jatuningtyas Ratih Kurnia , Purwaningsih Heni , Basuki Seno , Utomo Budi , Minarsih Sri 
Published: December 2023

Abstract
A collective action approach to rice seed production is an inclusive method involving the community’s active participation at all stages of its execution. This all-inclusive strategy, however, has yet to be thoroughly investigated and published. This study explored how and to what degree an inclusive rice seed business of Gapoktan, based on a collective action approach, might be deployed in a sustainable rice seed company run by community groups. The research comprised the following stages: (1) establishment of a seed production business institution, (2) production of rice seeds, and (3) self-assessment of the performance of the seed production business institution. Institutional data were acquired through a questionnaire that references the European Foundation for Quality Management’s (EFQM) methodology. Three dimensions used were direction (purpose, vision, and strategy; organizational culture and leadership); execution (engaging stakeholders; coasting sustainable value; driving performance transformation); and result (stakeholder perceptions; strategic and operational performance). The study suggests essential findings: The organizational structure of rice seed producers formed is complete regarding its operational functions. The rice seeds produced by Gapoktan have met both the volume and quality standards. From a financial perspective, this rice seed production unit is feasible for further development. However, their social orientation is still relatively high and needs to be more profit-oriented. Uniquely, not all members buy and use Gapoktan seeds. As a result, additional efforts are necessary to provide exceptional service to Gapoktan members.
Increasing Chlamydia and Gonorrhea Testing for Adolescents in the Pediatric Emergency Department
Authors: Vayngortin Tatyana , Gracia Michael , Clark Katie , Vayngortin Beata , Bialostozky Mario , Heitzman Lindsay , Hollenbach Kathryn , Kumar Maya , Titchen Kanani , Bryl Amy 
Published: December 2023

OBJECTIVE
Adolescents who use the emergency department are more likely to engage in high-risk sexual activity and are at an increased risk of sexually transmitted infections. We aimed to increase testing for Chlamydia and gonorrhea from 12% to 50% among adolescents presenting to our pediatric emergency department with at-risk chief complaints over 12 months.

METHODS
Plan-Do-Study-Act cycles were initiated in July 2020. A multidisciplinary team reviewed preexisting data and developed interventions to increase Chlamydia and gonorrhea testing in teens with at-risk complaints, including genitourinary and behavioral health complaints, and females with abdominal pain. Two categories of interventions were implemented: education and electronic medical record optimization. Process measures were the proportion of patients with a documented sexual history and the proportion of patients tested with a documented confidential phone number. Secondary outcome measures included the weekly number of positive test results and the proportion of patients testing positive who were contacted to arrange treatment. Statistical process control charts were used to examine changes in measures over time.

RESULTS
Within 14 months of project initiation, the proportion of at-risk patients tested increased from 12% to 59%. Teen phone number documentation remained unchanged from 23%. Sexual history documentation remained unchanged from 46%. The number of positive test results increased from 1.8 to 3.4 per month, and the proportion of patients testing positive who were contacted to arrange treatment remained unchanged at 83%.

CONCLUSIONS
We surpassed our goal and increased the proportion of at-risk patients tested for Chlamydia and gonorrhea to 59%, sustained for 4 months from the last intervention.
The utilization of metaverse technology applications based on science, technology, engineering and mathematics (Meta-STEM) to improve critical thinking skills
Authors: Rachmadtullah Reza , Setiawan Bramianto , Wasesa Andarmadi Jati Abdhi , Wicaksono Jatu Wahyu , Rasmitadila  
Published: December 2023

The existence of digital technology is currently seen as a system that helps teachers satisfy the needs of their students. The utilization of technology facilitates teachers’ ability to address students' low critical thinking abilities. Therefore, this research studied the utilization of Metaverse technology applications based on Science, Technology, Engineering and Mathematics (Meta-STEM) to improve critical thinking skills. The study used a quantitative research approach and adopted the true experimental design method. A pre- and post-tests control group design was used in this study. The research findings revealed a significant difference between the average outcomes of using Metaverse technology applications in the experimental group compared to the control group. Meta-STEM technology supported by the internet provides a fresh perspective on teaching methods especially in education. The present teaching methods use both virtual learning platforms and conventional face-to-face classrooms. The interaction process is becoming more dynamic and obtaining and searching for information is more accessible without spatial or temporal limitations. The implications of Meta-STEM for supporting learning can increase students' ability to gain information. In addition, there are numerous advantages to using Meta-STEM in the field of education for training and education. Providing impressive learning methods for students and teachers, making it easier for teachers to convey complex material, increasing students' level of understanding of the learning material presented by teachers as well as Meta-STEM can provide knowledge to master technology for students.
Optimised diets for improving human, animal, and environmental health in the Rhine-Ruhr Metropolis in Germany
Authors: Paris Juliana Minetto Gellert , Escobar Neus , Falkenberg Timo , Gupta Shivam , Heinzel Christine , Junior Eliseu Verly , Jolliet Olivier , Borgemeister Christian , Nöthlings Ute 
Published: December 2023

Abstract
Dietary shifts are needed to align the global food systems with the planetary boundaries and contribute to Sustainable Development Goals. We employed a Life Cycle Assessment (LCA) framework, extended with indicators on human health and animal welfare, to assess 2020 food consumption data (N=189) collected through an online survey in the Rhine-Ruhr Metropolis (Germany). Feasible optimisation scenarios representing alternative sustainable choices towards overarching environmental, societal and policy goals were explored. Meat and meat products contributed most to overall environmental impacts (e.g., climate change, terrestrial acidification), and fish and seafood to animal welfare loss (e.g., animal lives lost, animal life years suffered). Sodium intake was the most contributing risk factor for life minutes lost. The combined optimisation scenario reduces 55% of greenhouse gas emissions, improves human health indicators by 25% and reduces animal welfare loss substantially (by 52-97%). This is possible with a shift towards flexitarian and vegetarian dietary scenarios. Although the sample is not representative of the entire population, optimisations deliver sustainability improvements with few changes in dietary scenarios. The extended LCA framework can assess the implications of food consumption towards One Health, provided that further indicators on animal health are developed.
Influence of the Geographic differences to the Genetic Variation and Distribution of Vector Borne Mosquito in Filariasis Endemic Areas of Central Java Indonesia
Authors: astuti upiek ngesti wibawaning , Soesilohadi Hidayat , Nurcahyo Wisnu , Hadisusanto Suwarno , Mulyaningsih Budi , Syafruddin Din 
Published: December 2023

Abstract

Vector borne mosquito diseases are still as a public health problem in many countries in the world, including in Indonesia. Filariasis is a disease that is transmitted through mosquito bites and the cases are increasing in some areas in Indonesia. The information regarding the vectorCulex quinquefasciatusspecies distribution and the genetic variation in Indonesia have not been reported. The objective of the study was to determine the influence of geographyc differences to the distribution and genetic variation ofCx. quinquefasciatusthat was collected from 4 filariasis endemic areas in Central Java Indonesia. Mosquitoes were collected by using human landing collection method at night period. The mosquito distribution was analyzed with Kruskal Wallis test. DNAs of each mosquito specimens were then isolated and amplified by using 5 RAPD markers. DNA cluster analysis was done with MVSP™ software. A total of 396 mosquito specimens were collected and the PCR analysis revealed 945 fraghment, consisted of 40 monomorphic and 905 polymorphic fragments. The genetic similarities ranged from 0–75% in all collection areas. In conclusion, the study discovered up to a high genetic variation ofCx. quinquefasciatusand the distribution was significantly influenced by geographic position.
A Comprehensive Analysis of In-Hospital Adverse Events After Scopolamine Administration: Insights from a Retrospective Cohort Study Using a Large Nationwide Inpatient Database
Authors: Sun George , Min Kevin 
Published: December 2023

Abstract

Background: Scopolamine is a widely used antiemetic in anesthetic practice, particularly for postoperative and postdischarge nausea and vomiting. Despite its frequent usage and recognized efficacy, concerns have emerged regarding the potential for increased side effects, particularly in elderly patients. Further research is needed to assess safety and determine age thresholds for adverse events. This study hypothesizes associations between perioperative scopolamine use, worse clinical outcomes, increased pneumonia, delirium, urinary retention, and readmissions.Methods: A large, retrospective cohort study was performed using the TriNetX Analytics Network database on patients undergoing major surgical procedures between Jan 1, 2009, and March 21, 2018, to examine the impact of perioperative scopolamine use on in-hospital adverse events. Patients were divided into age groups and compared to a control group. The primary outcomes assessed were delirium, pneumonia, in-hospital death, new antipsychotic use, readmission, and new onset urinary retention within 7 days post-surgery. 1:1 propensity score matching was performed to reduce bias. Relative risk and risk differences with 95% confidence intervals were estimated.Results: After 1:1 propensity score matching, we identified a total of 345,812 (172,906 pairs) perioperative scopolamine users and nonusers. The cohorts of 65+, 60–64, 55–59, 50–54, and 45–49 contained 161,846 (80,923 pairs), 49,650 (24,825 pairs), 44,774 (22,387 pairs), 46,944 (23,472 pairs), and 42,598 (21,299 pairs) patients respectively. Across all age cohorts, after propensity score matching, perioperative scopolamine recipients had significantly increased relative risk and risk difference of delirium, pneumonia, in-hospital mortality, new antipsychotic use, readmission, and new-onset urinary retention.Conclusions: In this cohort study, perioperative scopolamine usage was associated with a significantly increased risk of in-hospital adverse events, both within the > 65 age cohort and among the 60–64, 55–59, 50–54, and 45–49 age cohorts after major surgery. These findings highlight the need for careful assessment of scopolamine's risks and benefits, especially for patients aged 45 and older. Scopolamine may be most suited for post-discharge nausea and vomiting in ambulatory patients and clinicians should reassess its standard use for postoperative nausea and vomiting, favoring shorter-acting agents with fewer side effects.
Seismic data and ancient zircons discovered on the Mendeleev Rise, Arctic Ocean, indicate continental crust
Authors: Nikishin Anatoly M. , Foulger Gillian R. , Rodina Elizaveta A. , Aleshina Ksenia F. , Posamentier Henry W. , Chernykh Andrey A. , Kuznetsov Nikolay B. 
Published: December 2023

Abstract
The Alpha-Mendeleev Rise is located in the Amerasia Basin. The work is based on a synthesis of interpretation of regional 2D MCS seismic profiles and data from rock sampling using special underwater vehicles on the slopes of seamounts. The Rise is represented by alternation of highs (horsts) and half-grabens. At the base of the horst cover, bright reflectors are distinguished, which are interpreted as volcanics. Half-graben sections are wedge-shaped and are similar in geometry to seaward-dipping reflectors (SDRs) of continental passive volcanic margins. Rock sampling has shown that the horsts are composed of sedimentary rocks of Paleozoic age, penetrated by intrusions. Aptian-Albian sections with volcanics (basalts, trachybasalts, trachyandesites) were identified on the horsts. U/Pb dating of igneous rocks showed that typical age of rocks is 110-114 Ma. Magmatic Cretaceous rocks contain zircons with ages ranging from pre-Barremian Mesozoic to Precambrian. The presence of these ancient zircons indicates that the Alpha-Mendeleev Rise is composed of continental crust. A model of the crustal structure of the Alpha-Mendeleev Rise is proposed. The upper and lower crust is approximately 20-30% saturated with intrusions of basic composition. At the base of the crust, a high-velocity layer up to 5 km thick is distinguished.
Thermomechanical Characterization of Oleogels elaborated with a Low Molecular Weight Ethyl Cellulose and Monoglycerides
Authors: García-Ortega Martha Laura , Charó-Alvarado Maria Eugenia , Pérez-Martínez Jaime David , Toro-Vazquez Jorge Fernando 
Published: December 2023

Abstract

The interaction between a low molecular weight (i.e., 19 kDa) ethyl cellulose (EC) and a commercial monoglyceride (MGc) in the development of EC-MGc oleogels was evaluated through rheological, DSC, and infrared spectroscopy measurements. The oleogels were developed through cooling (80°C to 2°C, 10°C/min) vegetal oil solutions of mixtures of EC at concentrations above (10%), below (7%), and at its minimal gelling concentration (8%), with MGc concentrations below its minimal gelling concentration (0%, 0.1%, 0.25%, 0.5%, 1%). At 0.10% MGc most of the monoglycerides developed hydrogen bonds with the EC. Thus, the EC-0.10% MGc oleogels were structured through EC-monoglyceride-EC interactions, that as the EC concentration increased entrapped the oil providing higher elasticity (G’) than the EC oleogels. At MGc concentrations ≥ 0.25% the higher relative polarity of the oil favored the EC-EC interactions over the EC-monoglyceride-EC interactions. At temperatures < 10°C the monoglycerides in the oil crystallized within the free spaces of the entangled EC fibers acting as active filler. Thus, at the same EC concentration the EC-0.25% MGc, EC-0.50% MGc, and EC-1% MGc oleogels achieved higher G’ than the corresponding EC-0.10% MGc oleogels (P < 0.01). This behavior was more evident as the EC concentration increased. Additionally, the rheological measurements during cooling showed that below 40°C the EC went through a structural rearrangement that decreased the oleogels’ elasticity. Since the structural rearrangement was cooling rate, EC and MGc concentration dependent, these factors could be used to tailor the rheological properties of oleogels developed with low molecular weight EC.
Low-dose SAHA enhances CD8+T cell-mediated antitumor immunity by upregulating MHC I expression in non-small cell lung cancers
Authors: Wang Baolong , He Bing , Cao Yanhong , Yang Rui , Zhang Shuang , Kong Yujie , Lu Dapeng , Luo Peng , Zheng Xu , Hou Yanjiao , Wang Chen , Wei Pingping , Xie Jun , Yu Shihao , Cui Dechun , Hao Wang , Dong Wenqian 
Published: December 2023

Abstract
Non-small cell lung cancers (NSCLCs) is a highly aggressive lung cancer with poor responses to traditional therapies like surgery, radiotherapy, and chemotherapy. While immunotherapy has become an effective approach treating multiple types of cancer, solid tumors frequently exhibit immune escape through various mechanisms, including downregulation of MHC I expression. Whether upregulating MHC I expression can improve the immunotherapeutic effect for NSCLCs remains unexplored. Suberoylanilide hydroxamic acid (SAHA) is a potent histone deacetylase (HDAC) inhibitor, which has been applied clinically to treat lymphoma, but high-dose of SAHA kills tumor cells and normal cells without preference. Here, we show that low-dose SAHA enhances CD8 + T cell-mediated antitumor immunity via upregulating MHC I expression in NSCLC cells. We also provide evidence that high levels of MHC I induced by SAHA promoted the activation, proliferation, and cytotoxicity of specific CD8+T cells in mouse models. Mechanistically, low-dose SAHA increases the levels of H3K9ac and H3K27ac in the promoters of STAT1, Smad2 and Smad3 genes in NSCLC cells by inhibiting HDAC activity, resulting in elevated expression levels of STAT1, Smad2 and Smad3. The nuclear translocation of phosphorylated STAT1 and Smad2/3 upregulates the expression of MHC I in NSCLC cells remarkably. Thus, we uncovered a key mechanism of SAHA-mediated enhanced antitumor immunity, providing insights into a novel immunotherapy strategy for NSCLC.
Deployment expectations of multi-gigaton scale of carbon dioxide removal could have adverse impacts on global climate system
Authors: Liu Haifeng , Ampah Jeffrey , JIN CHAO , YAO MINGFA , AFRANE SANDYLOVE , ADUN HUMPHREY , Fuhrman Jay , Ho David T. , McJeon Haewon 
Published: December 2023

Abstract

The window for limiting global warming to 1.5°C is rapidly closing, necessitating immediate climate action which some have proposed includes deploying carbon dioxide removal (CDR) at scale. However, CDR is characterized by varying trade-offs and spill-over effects, and an excessive reliance on them to reach climate milestones could affect global Earth system negatively. This study quantitatively investigates the impacts associated with different levels of reliance on negative emissions for Asia’s net zero ambitions. We employ a technology-rich integrated assessment model, i.e., GCAM-TJU, a modified version of the Global Change Assessment Model (GCAM) with the capability of deploying six different CDR approaches. Different levels of CDR reliance are modeled by varying CDR deployment times, availability, and removal capacities. Key findings are that deploying tens of gigaton scale of negative emissions by mid-century will perpetuate fossil fuel reliance, slow energy transitions and push back net zero timelines. High reliance on CDR also reduces building efficiency improvements and transport electrification rates significantly. Furthermore, timing of net zero for multiple Asian countries is advanced under lower availability of CDR, resulting in lower residual emissions with significant health co-benefits. Regarding land and food, high reliance on CDR leads to significant changes in land use with a severe reduction in cropland. There are potential concerns related to water demands and fertilizer needs under excessive reliance on CDR. Overall, our results show that tens of gigaton scale of negative emissions by mid-century could seriously impede climate goals. Prioritizing non-CDR mitigation strategies through rapid electrification, carbon-neutral/negative fuels (e.g., hydrogen), and efficiency mainstreaming could accelerate decarbonization. We must strive to pursue emission cuts maximally before utilizing negative emissions. While CDR is necessary for delivering the "net" in "net-zero emissions", it is worth exploring strategies that reduce the need for excessive reliance on CDR, while also capitalizing on its advantages when it is most viable.
Endovascular treatment of splenic artery aneurysm rupture - Case Report
Authors: Carvalho Márcia , Mendes João , Macedo-Oliveira Carlos , Freire Bárbara , Pereira-Macedo Juliana , Duque Rita Pinheiro , Lemos Ricardo , Sampaio Francisco 
Published: December 2023

Abstract
Background
Splenic artery aneurysm is a rare vascular pathology but is the most common visceral arterial aneurysm. Most of them are asymptomatic and diagnosed incidentally but can quickly become life-threatening when ruptured.
This is a rare case of a spontaneous splenic artery aneurysm rupture in a high-risk patient for surgery and endovascular treatment was the only option to save patient’s life.
Case presentation
We report a 70-year-old woman with multiple comorbidities, presenting to the emergency department with signs of shock: confusion, pallor, tachycardia and hypotension.
Computed tomography shows an active bleeding from a splenic artery aneurysm rupture. She was successfully submitted to emergent arterial embolization of the splenic artery aneurysm and discharged from hospital a few days later.
Conclusions
Endovascular treatment is a less aggressive approach and should be considered in high-risk patients for surgical treatment.
This is a case that shows the importance of immediate diagnosis and treatment is the only option to save patient’s life.
Structural recognition and stabilization of tyrosine hydroxylase by the J-domain protein DNAJC12
Authors: Martinez Aurora , Tai Mary Dayne , Ochoa Lissette , Flydal Marte , Velasco Lorea , Muntaner Jimena , Santiago Cesar , Jung-KC Kunwar , Moro Fernando , Kallio Juha , Muga Arturo , Valpuesta José , Cuellar Jorge 
Published: December 2023

Abstract
Pathogenic variants of the J-domain protein and Hsp70 cochaperone DNAJC12 cause parkinsonism, which is associated with a defective interaction of DNAJC12 with tyrosine hydroxylase (TH), the rate-limiting enzyme in dopamine (DA) biosynthesis. Here, we report the characterization of TH:DNAJC12 complex formation, showing that DNAJC12 binding stabilizes TH and delays its time-dependent aggregation in an Hsp70-independent manner, while maintaining TH activity and regulatory inhibition by DA. Interestingly, DNAJC12 alone barely activated Hsc70, the constitutively-expressed Hsp70 isoform, but in complex with TH, DNAJC12 efficiently stimulated Hsc70 ATPase activity. Cryoelectron microscopy revealed two DNAJC12 monomers bound per TH tetramer, each embracing one of the two regulatory domain dimers, leaving all active sites available for substrate and DA interaction. Our results confirm the key role of the C-terminal eight residues of DNAJC12 in TH binding, explaining the pathogenic mechanism of the disease variant DNAJC12(Trp175Ter).