bluuebunny/crossref_metadata_2025_split huggingface dataset:
Techno-Economic Review of Pyrolysis and Gasification Plants for Thermochemical Recovery of Plastic Waste and Economic Viability Assessment of Small-Scale Implementation
Authors: Tomić Tihomir , Slatina Iva , Schneider Daniel R. 
Published: October 2023

Abstract
Polymers used in the production of consumer products become a part of municipal waste streams after reaching the end of their useful lifespan, but also before even reaching markets, as rejects, scraps, and/or industry by-products as a part of industrial waste streams. Suitability for recovery of industrial wastes differs significantly and needs to be analyzed separately. In this research, a review of the techno-economic parameters of existing recovery plants is done. Dependences between economic and technological parameters, sizes, and types of plants, as well as the composition of input material, are derived. Based on the presented data, a techno-economic analysis of the small-scale implementation of thermochemical recovery plants, for industry-generated residual plastic waste fraction, is conducted. Results show that thermochemical conversion of industrial plastic waste cannot be economically viable on a small scale without a gate-fee. Pyrolysis plants brake even gate-fee is on the level of over 50/86 €/t, while treating only 51%/28% of residual waste, due to strict restrictions regarding feedstock composition. In the case of gasification, it is on the level of 70 €/t, while treating 92% of available waste. Pyrolysis is the only viable solution for treating up to 12 TPD after which gasification also becomes a viable option. Usual capacities are up to 25/100 TPD for pyrolysis/gasification, after which incineration-based technologies need to be considered. The presented results provide decision-makers with a good overview of alternative thermochemical conversion technologies, their technical characteristics, limitations, and possible economic outcomes of their implementation.
Cultivation of Chlorella vulgaris in wastewater: Biodiesel potential and wastewater remediation
Authors: Sarpal Amarjit S. , Teixeira Cláudia M. L. L. , COSTA Ingrid C. R 
Published: October 2023

Abstract

The present investigation has evaluated the use of effluents from a secondary municipal wastewater treatment plant for biomass production and the potential of the biomasses for biodiesel production. Cultivations of Chlorella vulgaris using wastewater, wastewater with supplementation and WC medium were carried out. Effect of wastewater collected in different months on biomass productivity and lipid composition was studied. The applicability of cultures produced with effluents in consecutive cultivations as inoculate were evaluated. NMR and GC-MS results were used for determining the composition of the lipids and their fatty acid profile including PUFAs. The product potential including biodiesel of the biomasses generated was also assessed. The results showed that it was possible to attain very reasonable biomass productivities (38.9 mgL− 1d− 1) using this kind of wastewater without supplementation. Also, the use of the cultures produced in these media proved to be adequate as inoculates in consecutive cultivations. Lipids extracted are comprising of both neutral (TAG, FFA) and polar (glyco glycero/phospho). The triacyl glycerides (TAG) content of the extracted lipids was determined in the range of 22.5–41.3%w/w. NMR and GC-MS results showed potential for microalgal lipids from biomasses cultivated in different wastewaters (collected in different moments) mainly without supplementation, for biodiesel production. The fatty acid profiles of both neutral and polar lipids are potential sources for the biodiesel industry. The biodiesel and PUFAs potentials of the polar lipids of biomasses cultivated in a medium containing higher amount of nitrates were also discussed.
The Transdiagnostic Intervention for Sleep and Circadian Dysfunction (TranS-C) for serious mental illness in community mental health part 3: Study protocol to evaluate sustainment in a hybrid type 2 effectiveness-implementation cluster-randomized trial
Authors: Sarfan Laurel D. , Agnew Emma R. , Diaz Marlen , Cogan Ashby , Spencer Julia M. , Hache Rafael Esteva , Stirman Shannon Wiltsey , Lewis Cara C. , Kilbourne Amy M. , Harvey Allison 
Published: October 2023

Abstract
treatments (EBPTs) has advanced rapidly, research on the sustainment of implemented EBPTs remains limited. This is concerning, given that EBPT activities and benefits regularly decline post-implementation. To advance research on sustainment, the present protocol focuses on the third and final phase – the Sustainment Phase – of a hybrid type 2 cluster-randomized controlled trial investigating the implementation and sustainment of the Transdiagnostic Intervention for Sleep and Circadian Dysfunction (TranS-C) for patients with serious mental illness and sleep and circadian problems in community mental health centers (CMHCs). Prior to the first two phases of the trial – the Implementation Phase and Train-the-Trainer Phase – TranS-C was adapted to fit the CMHC context. Then, 10 CMHCs were cluster-randomized to implement Standard or Adapted TranS-C via facilitation and train-the-trainer. The primary goal of the Sustainment Phase is to investigate whether adapting TranS-C to fit the CMHC context predicts improved sustainment outcomes.
Methods: Data collection for the Sustainment Phase will commence at least three months after implementation efforts in partnering CMHCs have ended and may continue for up to one year. CMHC providers will be recruited to complete surveys (N = 154) and a semi-structured interview (N = 40) on sustainment outcomes and mechanisms. Aim 1 is to report the sustainment outcomes of TranS-C. Aim 2 is to evaluate whether manipulating EBPT fit to context (i.e., Standard versus Adapted TranS-C) predicts sustainment outcomes. Aim 3 is to test whether provider perceptions of fit mediate the relation between treatment condition (i.e., Standard versus Adapted TranS-C) and sustainment outcomes. Mixed methods will be used to analyze the data.
Discussion: The present study seeks to advance our understanding of sustainment predictors, mechanisms, and outcomes by investigating (a) whether the implementation strategy of adapting an EBPT (i.e., TranS-C) to the CMHC context predicts improved sustainment outcomes and (b) whether this relation is mediated by improved provider perceptions of treatment fit. Together, the findings may help inform more precise implementation efforts that contribute to lasting change.
Trial Registration: ClinicalTrials.gov identifier: NCT05956678. Registered on July 21, 2023. https://classic.clinicaltrials.gov/ct2/show/NCT05956678?term=NCT05956678&draw=2&rank=1
Engaging science across cultures: building a research community of Buddhist monastics and undergraduate and faculty mentors
Authors: Goldberg David , Poppitz George , Sonsurkar Sayli , Manuel Josh , Klaus Jacob , Zhang Eric , Goldberg Michael , Gray Kelsey , Eisen Arri 
Published: October 2023

Abstract

Emory University has had a long relationship with His Holiness the Dalai Lama through the Emory-Tibet Science Initiative. Recently the Tenzin Gyatso Science Scholars, who are Tibetan Buddhist monastics that reside and take courses on Emory’s campus, were enrolled in a novel science research course designed and taught by undergraduate students at Emory. The course covered aspects of the scientific method and focused on enhancing engagement and motivation of the Scholars to pursue science research. Knowledge acquisition was assessed through quizzes, affect changes were assessed through focus group interviews, and overall course success was measured through Principal Investigator surveys. Conceptual knowledge and overall average improvement increased significantly week-to-week. Changes in affect for self-efficacy, belonging, knowledge, and future applications/drive trended towards improvement in each respective category. Finally, all seven Monastic Scholars who participated in the research curriculum were enrolled in R1 research experiences after conclusion of the course, and their PIs positively evaluated the preparedness and motivation of the monastics. The curriculum detailed here and its implementation facilitated cross-cultural education and successfully transitioned students from the classroom into research laboratories.
Estimation of Curie-point depth, heat flow and geothermal gradients in Shelleng area and environs, northeastern Nigeria from aeromagnetic data
Authors: Yassah Hassan Nelson , Onuoha Mosto , Mode Wilfred , Ezekiel Kamureyina , Okoro Eze Martins 
Published: October 2023

Abstract

Regional estimation of Curie-point depth (CPD), subsurface heat flow and geothermal gradients variations in the Shelleng area and environs of northeastern Nigeria was carried out in this study using spectral analysis of high-resolution aeromagnetic (HRAM) data. The HRAM data were divided into nine (9) overlapping blocks and each of the blocks was analyzed to obtain the 2D radially averaged power spectrum which enabled the computation of depths to the top and centroid of magnetic sources. The obtained values were then used to determine the depth to the bottom of magnetic bodies or the CPD, geothermal gradients and crustal heat flow changes in the study area. Results showed that CPD varies from 7.56 to 18.01 km, with an average of 11.72 km; geothermal gradient values vary between 32.20 and 76.72°C/km, with an average of 52.76°C/km, while heat flow variations range from 80.51 to 191.80 mW/m2, with an average of 131.85 mW/m2. Shallow CPD zones identified in the northeastern, western and southwestern portions of the study area correspond to zones of high geothermal gradient values and high subsurface heat flow distributions. These areas signify zones associated with anomalous subsurface thermal conditions and were therefore recommended for further detailed geothermal energy exploration studies.
Assessing Sustainable Waste Management Practices in Rajshahi City Corporation: An Analysis for Local Government Enhancement using IoT and AI Technology
Authors: Hossain Imran , Haque AKM Mahmudul , Ullah SM Akram 
Published: October 2023

Abstract
This study examines the possible improvements that could be made by combining the Internet of Things (IoT) and artificial intelligence (AI) technology to improve waste management methods in Rajshahi City Corporation (RCC), Bangladesh. The study's foundation is a vast amount of information gathered from residents, with particular attention paid to waste disposal methods, the role of the local government, the frequency of waste collection, and public attitudes toward waste management. The results point to a complicated waste management environment with a range of waste disposal practices, little supervision, irregular waste collection, and insufficient disposal methods. The importance of RCC in waste management is emphasized, highlighting the need for proactive measures including effective monitoring, constant waste collection, and routine drain cleaning. Additionally, it is suggested that combining IoT and AI technology is a possible way to improve waste management procedures. These technologies have the potential to increase productivity, lessen their negative effects on the environment, and produce cleaner, more sustainable urban environments. This study emphasizes the significance of a thorough waste management strategy that incorporates technologically-based solutions and community involvement. It helps transform RCC into a smart city with effective and eco-friendly waste management methods, creating a precedent for other municipalities worldwide. It also acts as a valuable model for addressing waste management difficulties in urban areas.
Assessment of Fenobucarb and Propoxur insecticides in environmental samples by spectrophotometric and spectrofluorimetric methods
Authors: Chaudhary Akhil , Sharma Nisha 
Published: October 2023

Abstract

The widespread use of fenobucarb and propoxur insecticides for agricultural and non-agricultural purposes causes undesirable effects on human health and environment due to their residues in surface and ground water resources. In view of this two new, simple, accurate, sensitive, economical and reproducible optical methods have been investigated for the determination of fenobucarb and propoxur insecticides in pure form, in their commercial formulations and agricultural samples viz. water, grains and vegetables. The methods are based on the alkaline hydrolysis of the insecticides to methyl amine and the reaction of latter to give colored products. In spectrophotometric method the methyl amine formed, in presence of carbon disulfide and Ni(II)acetate gives a yellow colored complex, which was measured at 370 nm. Beer’s law is valid in the concentration range of 0.41–8.29 and 0.42–8.37 µg/ mL for fenobucarb and propoxur respectively. The spectrofluorimetric method is based on the study of yellow colored product, formed by the condensation of methyl amine, with acetylacetone and formaldehyde (Hantzsch reaction) at pH 5.5. The reaction product exhibits fluorescence intensity at an emission wavelength of 470 nm after excitation at a wavelength of 390 nm for both fenobucarb and propoxur insecticides. The method has linearity range 0.14–5.53 and 0.14–5.58 µg/ mL for fenobucarb and propoxur respectively. The different factors which affect the reactions were thoroughly studied and optimized. The proposed methods have been successfully applied for the assay of both insecticides in their commercial formulations and for recovery study from spiked environmental samples. The good results of recoveries of both insecticides demonstrate the accuracy and precision of both methods.
Bilateral nephrocalcinosis: an unusual presentation in early childhood with PKHD1 biallelic inheritance
Authors: Krall Paola , Faúndes Victor , Galvez Carla , Cavagnaro Felipe 
Published: October 2023

Abstract
Background: Nephrocalcinosis (NC) is characterized by an excessive accumulation of calcium deposits in the kidneys. In children, it is often incidentally discovered with an uncertain prognosis.
Case-diagnosis/treatment: A 3-month-old girl suspected to have a milk protein allergy underwent an abdominal ultrasound that revealed increased echogenicity in the renal pyramids. Over the course of a 5-year follow-up, her kidneys maintained size within the upper limits, and echographies suggested medical nephropathy. By age 6, imaging findings were consistent with medullary NC. Further analysis identified PKHD1variants, which required bioinformatic tools to guide diagnosis. Until the age of 7, her kidney function has remained intact; however, her prognosis is uncertain. Conclusions: NC in newborns is rare, but its incidence is rising. Recurrent urinary infections or kidney stones may lead to kidney failure. A proactive approach in sporadic NC enables an early diagnosis to orientate nephrological supervision and facilitates counseling to support family planning decisions.
Anthropometric indicators may explain the high incidence of follicular lymphoma in Europeans: Results from a bidirectional two-sample two-step Mendelian randomisation
Authors: Zhou Yanqun , Zhang Xiongfeng , Zhu Guoqing , Li Xiaozhen , Gao Tianqi , Deng Yingying , Huang Liming , Liu Zenghui 
Published: October 2023

Abstract
Background
Non-Hodgkin's lymphoma incidence rates vary between European and Asian populations. The reasons remain unclear. This two-sample two-step Mendelian randomisation (MR) study aimed to investigate the causal relationship between anthropometric indicators (AIs) and diffuse large B-cell lymphoma (DLBCL) and follicular lymphoma (FL) and the possible mediating role of basal metabolic rate (BMR) in Europe. (2)
Methods
We used the following AIs as exposures: body mass index (BMI), whole-body fat mass (WBFM), whole-body fat-free mass (WBFFM), waist circumference(WC), hip circumference(HC), standing height (SH), and weight(Wt). DLBCL and FL represented the outcomes, and BMR was a mediator. A two-sample MR analysis was performed to examine the association between AIs and DLBCL and FL onset. We performed reverse-MR analysis to determine whether DLBCL and FL interfered with the AIs. A two-step MR analysis was performed to determine whether BMR mediated the causality. (3) Findings: WBFFM and SH had causal relationships with FL. A causal association between AIs and DLBCL was not observed. Reverse-MR analysis indicated the causal relationships were not bidirectional. Two-step MR suggested BMR may mediate the causal effect of WBFFM and SH on FL. (4)
Conclusions
We observed a causal relationship between WBFFM and SH and the onset of FL in Europeans, Which may explain the high incidence of follicular lymphoma in Europeans.
Development of a complex medication review intervention based on the secondment of a clinical pharmacist in general practice
Authors: Holst Sara Sommer , Hansen Johanne , Vermehren Charlotte 
Published: October 2023

Abstract

Background
Medication reviews (MRs) are a well-described initiative that improves several health outcomes for polypharmacy patients. It is a complex process that can include several elements and different healthcare professionals. When developing complex interventions, it is essential to describe the development process to ensure transparency and avoid research waste. Thus, this study aimed to describe the steps of developing an MR intervention targeting general practice to ensure transparency and transferability.
Methods
A stepwise approach inspired by the Medical Research Council framework was utilised in the process, covering two phases, i.e. development and feasibility, and five steps: 1) intervention drafting, 2) expert opinion feedback, 3) pilot testing, 4) pilot evaluation and 5) feasibility evaluation.
Results
Based on the results from the first three steps, four main themes were identified: general practitioner resources, patient involvement, implementation difficulties and interdisciplinarity. These themes guided the pilot evaluation in step 4. Lastly, the feasibility of the MR intervention was evaluated in step 5 through qualitative observations and semi-structured interviews of participants (not included in this study).
Conslusion
This study summarised the development and evaluation of a feasible, complex MR intervention utilising clinical pharmacists in general practice in a real-life setting.
Multi-omics elucidated parasite-host-microbiota interactions and resistance to Haemonchus contortus in sheep
Authors: Niciura Simone Cristina Méo , Cardoso Tainã Figueiredo , Ibelli Adriana Mercia Guaratini , Okino Cintia Hiromi , Andrade Bruno Gabriel , Benavides Magda Vieira , Chagas Ana Carolina de Souza , Esteves Sergio Novita , Minho Alessandro Pelegrine , Regitano Luciana Correia de Almeida , Gondro Cedric 
Published: October 2023

Abstract
Background:
The integration of molecular data from hosts, parasites, and microbiota can enhance our understanding of the complex biological interactions underlying parasite resistance. Haemonchus contortus, the predominant sheep parasite species in the tropics, results in significant production and economic losses, which are further compounded by the diminishing efficiency of chemical control measures due to anthelmintic resistance. Knowledge of how the host responds to infection and how the parasite, in combination with microbiota effects, modulates host immunity can guide selection decisions to breed more resistant animals. This understanding can also refine management practices and inform the development of new therapeutics for long-term helminth control.
Results:
Egg per gram (EPG) counts were obtained in Morada Nova sheep subjected to two artificial infections with H. contortus, and used as a proxy to select animals with high resistance or susceptibility. The GAST, GNLY, IL13, MGRN1, FGF14, and RORC genes and transcripts were differentially expressed between groups based on RNA-seq of the abomasum. From 50K SNP genotyping, EPG heritability estimate was 0.12, and a genome-wide association study (GWAS) identified regions on chromosomes 2 and 11 harboring candidate genes for resistance, immune response, body weight, and adaptation. Trans-eQTLs between significant variants and differentially expressed transcripts were found. Amplicon sequence variants (ASVs) from PCR amplification and sequencing of bacterial and archaeal 16S rRNA genes in sheep feces and rumen generated functional co-expression modules correlated with resistance to H. contortus, showing enrichment in pathways of response to bacterium, immune and inflammatory responses, and hub features of the Christensenellaceae, Bacteroides, and Methanobrevibacter genera, Prevotellaceae family, and Verrucomicrobiota. In RNA-seq of H. contortus, some mitochondrial, collagen- and cuticle-related genes were expressed only in parasites retrieved from susceptible sheep.
Conclusions:
This study identified chromosome regions, genes, transcripts, and pathways involved in the elaborate interactions between the sheep host, its gastrointestinal microbiota and the H. contortus parasite. These findings can assist with the development of animal selection strategies for parasite resistance and interdisciplinary approaches to control H. contortus in sheep.
Outcomes and prognosis of haploidentical haematopoietic stem cell transplantation in children with FLT3-ITD mutated acute myeloid leukaemia
Authors: Shang Qianwen , Bai Lu , Cheng Yifei , Suo Pan , Hu Guanhua , Yan Chenhua , Wang Yu , Zhang Xiaohui , Xu Lanping , Liu Kaiyan , Huang XiaoJun 
Published: October 2023

Abstract
The presence of internal tandem duplication mutations in the FMS-like tyrosine kinase 3 receptor (FLT3-ITD) is a poor prognostic predictor in paediatric patients with acute myeloid leukaemia (AML). We evaluated the treatment outcomes and prognostic factors of 45 paediatric patients with FLT3-ITD AML who achieved complete remission before haploidentical haematopoietic stem cell transplantation (haplo-HSCT) at our institution from 2012 to 2021. Among the 45 patients, the overall survival (OS), event‑free survival (EFS), and cumulative incidence of relapse (CIR) rates were 74.9%±6.6%, 64.1%±7.2%, and 31.4%±7.1%, respectively, with 48.8 months of median follow-up. Univariate and multivariate analyses associated positive minimal residual disease (MRD) at pre-HSCT , MRD by flow cytometry (FCM)≥0.1% after two cycles induction and time from diagnosis to HSCT more than 24 months with inferior long-term survival. The 4-year CIR of grade II–IV acute graft-versus-host (GVHD) and chronic GVHD after transplantation were 53.3% ± 7.6% and 35.7% ± 9.8%, respectively. In conclusion, haplo-HSCT may be a feasible strategy for paediatric patients with FLT3-ITD AML. MRD status at pre-HSCT, MRD by FCM after two cycles induction and the time from diagnosis to HSCT affect patient outcomes.