bluuebunny/crossref_metadata_2025_split huggingface dataset:
Synthesis of Mesoporous Core Shell Magnetite Bioactive Glass Nanoparticles for Magnetic Hyperthermia Treatment of Cancer
Authors: Goel Divya , Santhiya Deenan , Kumar Subodh , Kumar Mahapatro Ajit 
Published: January 2024

AbstractMultiple biological advances have made use of bioactive glass (BG) nanoparticles (NPs) in regenerative medicine, bone and tooth repair, drug and gene transfer, cancer treatment, and cosmetics. Normal biocompatible coatings alongside hydrocarbons, polymers, and silica significantly affect fundamental attributes of NPs. In this study, we synthesized a novel mesoporous BG NPs with magnetite core shell (AMAG_BG) using L‐arginine as a template processing magnetic hyperthermia (MH). BG network coverage on magnetite (AMAG) NPs were orchestrated first time by bio‐inspired synthesis in watery dissolvable. AMAG and AMAG_BG NPs were characterized by utilizing FE‐SEM, HR‐TEM, and BET analysis. The elemental composition of L‐arginine templated magnetite (AMAG) and AMAG_BG NPs was also determined by XPS and EDX analysis. Characteristics of AMAG_BG were contrasted with bare AMAG NPs in morphology, particle size, porosity, and composition. The fabricated BG NPs′ in‐vitro bioactivity and heat studies were successfully monitored after interaction with simulated bodily fluid (SBF). Magnetic studies and in‐vitro heat studies together demonstrated the behavior of BG NPs towards MH treatment of cancerous cells. Cytotoxicity tests on AMAG_BG NPs using U2OS and human blood cells with appropriate control experiments revealed biocompatibility. The study represents magnetic and thermal property‐dependent sustainable synthetic process of AMAG BG NPs for cancer treatment.
Whole‐genome sequencing in prenatally detected congenital malformations: prospective cohort study in clinical setting
Authors: Westenius E. , Conner P. , Pettersson M. , Sahlin E. , Papadogiannakis N. , Lindstrand A. , Iwarsson E. 
Published: January 2024

ABSTRACTObjectiveTo investigate the diagnostic yield of trio whole‐genome sequencing (WGS) in fetuses with various congenital malformations referred to a tertiary center for prenatal diagnosis.MethodsIn this prospective study, 50 pregnancies with different congenital malformations, negative for trisomies and causative copy‐number variants, were analyzed further with fetal–parental trio WGS analysis. Parents were eligible for inclusion if they accepted further investigation following the detection of isolated or multiple malformations on prenatal ultrasound. Cases with isolated increased nuchal translucency, gamete donation or multiple pregnancy were excluded. WGS with the Illumina Inc. 30× polymerase‐chain‐reaction‐free short‐read sequencing included analysis of single‐nucleotide variants, insertions and deletions, structural variants, short tandem repeats and copy‐number identification of SMN1 and SMN2 genes.ResultsA molecular diagnosis was achieved in 13/50 (26%) cases. Causative sequence variants were identified in 12 genes: FGFR3 (n = 2), ACTA1 (n = 1), CDH2 (n = 1), COL1A2 (n = 1), DHCR7 (n = 1), EYA1 (n = 1), FBXO11 (n = 1), FRAS1 (n = 1), L1CAM (n = 1), OFD1 (n = 1), PDHA1 (n = 1) and SOX9 (n = 1). The phenotypes of the cases were divided into different groups, with the following diagnostic yields: skeletal malformation (4/9 (44%)), multisystem malformation (3/7 (43%)), central nervous system malformation (5/15 (33%)) and thoracic malformation (1/10 (10%)). Additionally, two cases carried variants that were considered potentially clinically relevant, even though they were assessed as variants of uncertain significance, according to the guidelines provided by the American College of Medical Genetics and Genomics. Overall, we identified a causative or potentially clinically relevant variant in 15/50 (30%) cases.ConclusionsWe demonstrate a diagnostic yield of 26% with clinical WGS in prenatally detected congenital malformations. This study emphasizes the benefits that WGS can bring to the diagnosis of fetal structural anomalies. It is important to note that causative chromosomal aberrations were excluded from our cohort before WGS. As chromosomal aberrations are a well‐known cause of prenatally detected congenital malformations, future studies using WGS as a primary diagnostic test, including assessment of chromosomal aberrations, may show that the detection rate exceeds the diagnostic yield of this study. WGS can add clinically relevant information, explaining the underlying cause of the fetal anomaly, which will provide information concerning the specific prognosis of the condition, as well as estimate the risk of recurrence. A genetic diagnosis can also provide more reproductive choice for future pregnancies. © 2024 The Authors. Ultrasound in Obstetrics & Gynecology published by John Wiley & Sons Ltd on behalf of International Society of Ultrasound in Obstetrics and Gynecology.
From free-fermionic constructions to orbifolds and back
Authors: Florakis Ioannis , Rizos John 
Published: January 2024

AbstractWe systematically develop the explicit map between string vacua constructed in the Free Fermionic Formulation and their$$ {\mathbb{Z}}_2^N $$ℤ2Ntoroidal orbifold counterparts. We illustrate the map in various example classes of models, including cases relevant for string phenomenology, as well as in theories where space-time supersymmetry is broken by the stringy Scherk-Schwarz mechanism.
Factorization and resummation for sequential recombination jet cross sections
Authors: Becher Thomas , Haag Jürg 
Published: January 2024

Abstract
We extend the class of factorization theorems for non-global observables from fixed angular constraints to cross sections defined in terms of sequential jet clustering. The associated hard and soft functions depend not only on the directions of the hard partons, but also on their energy fractions. We derive the one-loop anomalous dimension of the hard functions that drives the leading-logarithmic resummation. The anomalous dimension imposes energy ordering, which simplifies the clustering sequence. We perform resummations for gap-between-jet observables defined with different jet algorithms and explain the effects of the clustering on the importance of secondary emissions and on the effective gap size.
Determining economic factors for sex trafficking in the United States using count time series regression
Authors: Jang Yuhyeong , Sundararajan Raanju R. , Barreto-Souza Wagner , Wheaton-Paramo Elizabeth 
Published: January 2024

AbstractThe article presents a robust quantitative approach for determining significant economic factors for sex trafficking in the United States. The aim is to study monthly counts of sex trafficking-related convictions, and use a wide range of economic variables as covariates to investigate their effect on conviction counts. A count time series model is considered along with a regression setup to include economic time series as covariates (economic factors) to explain the counts on sex trafficking-related convictions. The statistical significance of these economic factors is investigated and the significant factors are ranked based on appropriate model selection methods. The inclusion of time-lagged versions of the economic factor time series in the regression model is also explored. Our findings indicate that economic factors relating to immigration policy, consumer price index and labor market regulations are the most significant in explaining sex trafficking convictions.
Intermittency and Lower Dimensional Dissipation in Incompressible Fluids
Authors: De Rosa Luigi , Isett Philip 
Published: January 2024

AbstractIn the context of incompressible fluids, the observation that turbulent singular structures fail to be space filling is known as “intermittency”, and it has strong experimental foundations. Consequently, as first pointed out by Landau, real turbulent flows do not satisfy the central assumptions of homogeneity and self-similarity in the K41 theory, and the K41 prediction of structure function exponents$$\zeta _p={p}/{3}$$ζp=p/3might be inaccurate. In this work we prove that, in the inviscid case, energy dissipation that is lower-dimensional in an appropriate sense implies deviations from the K41 prediction in everyp-th order structure function for$$p>3$$p>3. By exploiting a Lagrangian-type Minkowski dimension that is very reminiscent of the Taylor’sfrozen turbulencehypothesis, our strongest upper bound on$$\zeta _p$$ζpcoincides with the$$\beta $$β-model proposed by Frisch, Sulem and Nelkin in the late 70s, adding some rigorous analytical foundations to the model. More generally, we explore the relationship between dimensionality assumptions on the dissipation support and restrictions on thep-th order absolute structure functions. This approach differs from the current mathematical works on intermittency by its focus on geometrical rather than purely analytical assumptions. The proof is based on a new local variant of the celebrated Constantin-E-Titi argument that features the use of a third order commutator estimate, the special double regularity of the pressure, and mollification along the flow of a vector field.
Exploring the application limits of different hold-up time markers in supercritical fluid chromatography
Authors: Rédei Csanád , Buratti Alessandro , Catani Martina , Felinger Attila 
Published: January 2024

AbstractThe study focuses on the application range of nitrous oxide as a hold-up time marker in supercritical fluid chromatography (SFC). This compound has been suggested a decade ago to be used as unretained marker, something that the field of SFC was missing for a long time, since its beneficial properties make it an ideal candidate as hold-up time marker. Determination of the hold-up volume and actual volumetric flow rates have always been problematic in SFC due to the compressibility of carbon dioxide and one part of this is the difficulty of hold-up time measurements. Depending on the mobile phase, different methods have been used to measure the hold-up time with varying results. Nitrous oxide and other molecules have been compared in different conditions, mobile phases and stationary phases. In all cases, nitrous oxide gave the lowest elution times. However, detection was difficult in mobile phases containing 10% or more of organic modifier, because most solvents mask the signal of nitrous oxide. Interestingly, the choice of stationary phase also had a slight effect on detection, while different pressure and temperature settings affected each compound in a different manner.
Renal Function After CT-Guided Cryoablation of Small Renal Tumours in Patients with Solitary Kidney: An Analysis of European Multinational Prospective EuRECA Registry
Authors: Pietersen Pia I. , Stougaard Sarah , Keeley Francis X. , Lagerveld Brunolf , Breen David , King Alexander , Nielsen Tommy K. , van Strijen Marco , Garnon Julien , Alcorn Des , de Kerviler Eric , Zondervan Patricia , Wah Tze M. , Junker Theresa , Graumann Ole 
Published: January 2024

Abstract
Purpose
Treatment of renal cell carcinoma (RCC) in patients with solitary kidneys remains challenging. The purpose of this multicentre cohort study was to explore how renal function is affected by percutaneous image-guided cryoablation in patients with solitary kidneys.

Material and Methods
Data from the European Registry for Renal Cryoablation database were extracted on patients with RCC in solitary kidneys treated with image-guided, percutaneous cryoablation. Patients were excluded if they had multiple tumours, had received previous treatment of the tumour, or were treated with more than one cryoablation procedure. Pre- and post-treatment eGFR (within 3 months of the procedure) were compared.

Results
Of 222 patients with solitary kidneys entered into the database, a total of 70 patients met inclusion criteria. The mean baseline eGFR was 55.8 ± 16.8 mL/min/1.73 m2, and the mean 3-month post-operative eGFR was 49.6 ± 16.5 mL/min/1.73 m2. Mean eGFR reduction was − 6.2 mL/min/1.73 m2 corresponding to 11.1% (p = 0.01). No patients changed chronic kidney disease group to severe or end-stage chronic kidney disease (stage IV or V). No patients required post-procedure dialysis.

Conclusion
Image-guided renal cryoablation appears to be safe and effective for renal function preservation in patients with RCC in a solitary kidney. Following cryoablation, all patients had preservation of renal function without the need for dialysis or progression in chronic kidney disease stage despite the statistically significant reduction in eGFR.

Level of Evidence 3
Observational study.

Graphical Abstract
Dynamical downscaling of CMIP6 scenarios with ENEA-REG: an impact-oriented application for the Med-CORDEX region
Authors: Anav Alessandro , Antonelli Marta , Calmanti Sandro , Carillo Adriana , Catalano Franco , Dell’Aquila Alessandro , Iacono Roberto , Marullo Salvatore , Napolitano Ernesto , Palma Massimiliano , Pisacane Giovanna , Sannino Gianmaria , Struglia Maria Vittoria 
Published: January 2024

AbstractIn the framework of the coordinated regional modeling initiative Med-CORDEX (Coordinated Regional Climate Downscaling Experiment), we present an updated version of the regional Earth System Model ENEA-REG designed to downscale, over the Mediterranean basin, the models used in the Coupled Model Intercomparison Project phase 6 (CMIP6). The regional ESM includes coupled atmosphere (WRF), ocean (MITgcm), land (Noah-MP, embedded within WRF), and river (HD) components with spatial resolution of 12 km for the atmosphere, 1/12° for the ocean and 0.5° for the river rooting model. For the present climate, we performed a hindcast (i.e. reanalysis-driven) and a historical simulation (GCM-driven) over the 1980–2014 temporal period. The evaluation shows that the regional ESM reliably reproduces the mean state, spatial and temporal variability of the relevant atmospheric and ocean variables. In addition, we analyze the future evolution (2015–2100) of the Euro-Mediterranean climate under three different scenarios (SSP1-2.6, SSP2-4.5, SSP5-8.5), focusing on several relevant essential climate variables and climate indicators for impacts. Among others, results highlight how, for the scenarios SSP2-4.5 and SSP5-8.5, the intensity, frequency and duration of marine heat waves continue to increase until the end of the century and anomalies of up to 2 °C, which are considered extreme at the beginning of this century, will be so frequent to become the norm in less than a hundred years under the SSP5-8.5 scenario. Overall, our results demonstrate the improvement due to the high-resolution air–sea coupling for the representation of high impact events, such as marine heat waves, and sea-level height.
Development of an image-based Random Forest classifier for prediction of surgery duration of laparoscopic sigmoid resections
Authors: Lippenberger Florian , Ziegelmayer Sebastian , Berlet Maximilian , Feussner Hubertus , Makowski Marcus , Neumann Philipp-Alexander , Graf Markus , Kaissis Georgios , Wilhelm Dirk , Braren Rickmer , Reischl Stefan 
Published: January 2024

Abstract
Purpose
Sigmoid diverticulitis is a disease with a high socioeconomic burden, accounting for a high number of left-sided colonic resections worldwide. Modern surgical scheduling relies on accurate prediction of operation times to enhance patient care and optimize healthcare resources. This study aims to develop a predictive model for surgery duration in laparoscopic sigmoid resections, based on preoperative CT biometric and demographic patient data.

Methods
This retrospective single-center cohort study included 85 patients who underwent laparoscopic sigmoid resection for diverticular disease. Potentially relevant procedure-specific anatomical parameters recommended by a surgical expert were measured in preoperative CT imaging. After random split into training and test set (75% / 25%) multiclass logistic regression was performed and a Random Forest classifier was trained on CT imaging parameters, patient age, and sex in the training cohort to predict categorized surgery duration. The models were evaluated in the test cohort using established performance metrics including receiver operating characteristics area under the curve (AUROC).

Results
The Random Forest model achieved a good average AUROC of 0.78. It allowed a very good prediction of long (AUROC = 0.89; specificity 0.71; sensitivity 1.0) and short (AUROC = 0.81; specificity 0.77; sensitivity 0.56) procedures. It clearly outperformed the multiclass logistic regression model (AUROC: average = 0.33; short = 0.31; long = 0.22).

Conclusion
A Random Forest classifier trained on demographic and CT imaging biometric patient data could predict procedure duration outliers of laparoscopic sigmoid resections. Pending validation in a multicenter study, this approach could potentially improve procedure scheduling in visceral surgery and be scaled to other procedures.
Use of ClearGuard HD caps in pediatric hemodialysis patients
Authors: Nau Amy , Richardson Troy , Cardwell Diana , Ehrlich Jennifer , Gattineni Jyothsna , Hanna Melisha , Keswani Mahima , Neibauer Emily , Nitz Kelly , Quigley Raymond , Rheault Michelle , Sims Rebekah , Woo Mayna , Warady Bradley A. 
Published: January 2024

Abstract
Background
Bloodstream infections (BSIs) are a leading cause of hospitalizations and mortality among patients receiving hemodialysis (HD) therapy, especially those with a central venous catheter (CVC) for dialysis access. The use of chlorhexidine impregnated catheter caps (ClearGuard) has been associated with a decrease in the rate of HD catheter-related BSIs (CA-BSIs) in adults; similar data have not been published for children.

Methods
We compared CA-BSI data from participating centers within the Standardizing Care to Improve Outcomes in Pediatric Endstage Kidney Disease (SCOPE) collaborative based on the center’s use of ClearGuard caps for patients with HD catheter access. Centers were characterized as ClearGuard (CG) or non-ClearGuard (NCG) centers, with CA-BSI data pre- and post-CG implementation reviewed. All positive blood cultures in participating centers were reported to the SCOPE collaborative and adjudicated by an infectious disease physician.

Results
Data were available from 1786 SCOPE enrollment forms completed January 2016–January 2022. January 2020 served as the implementation date for analyzing CG versus NCG center data, with this being the time when the last CG center underwent implementation. Post January 2020, there was a greater decrease in the rate of HD CA-BSI in CG centers versus NCG centers, with a decrease from 1.18 to 0.23 and 0.41 episodes per 100 patient months for the CG and NCG centers, respectively (p = 0.002).

Conclusions
Routine use of ClearGuard caps in pediatric dialysis centers was associated with a reduction of HD CA-BSI rates in pediatric HD patients.

Graphical abstract
Risk factors for recurrence in pediatric urinary stone disease
Authors: Demirtas Ferhan , Çakar Nilgün , Özçakar Zeynep Birsin , Akıncı Aykut , Burgu Berk , Yalçınkaya Fatoş 
Published: January 2024

Abstract
Background
Children’s urinary system stones may develop from environmental, metabolic, anatomical, and other causes. Our objective is to determine the recurrence and prognosis, demographic, clinical, and etiological characteristics of children with urolithiasis.

Methods
Medical records of patients were evaluated retrospectively. Patients’ demographic data and medical history, serum/urine biochemical and metabolic analysis, blood gas analysis, stone analysis, imaging findings, and medical/surgical treatments were recorded.

Results
The study included 364 patients (male 187). Median age at diagnosis was 2.83 (IQR 0.83–8.08) years. The most common complaints were urinary tract infection (23%) and urine discoloration (12%). Sixty-two percent had a family history of stone disease. At least one metabolic disorder was found in 120 (88%) of 137 patients having all metabolic analyses: hypercalciuria was found in 45%, hypocitraturia in 39%, and hyperoxaluria in 37%. Anatomical abnormalities were detected in 18% of patients. Of 58 stones analyzed, 65.5% were calcium and 20.6% were cystine stones. Stone recurrence rate was 15% (55/364). Older age (> 5 years), family history of stone disease, stone size (≥ 5 mm), and urinary system anatomical abnormalities were significantly associated with stone recurrence (p = 0.027, p = 0.031, p < 0.001, and p < 0.001, respectively). In adjusted logistic regression analysis, stone size ≥ 5 mm (OR 4.85, 95% CI 2.53–9.3), presence of urinary system anatomical abnormalities (OR 2.89, 95% CI 1.44–5.78), and family history of stone disease (OR 2.41, 95% CI 1.19–4.86) had increased recurrence rate.

Conclusions
All children with urolithiasis should be evaluated for factors affecting stone recurrence. Children at higher risk of recurrence need to be followed carefully.

Graphical abstract
Uveitis intermedia
Authors: Sommer Michael , Singer Christoph , Werkl Peter , Seidel Gerald 
Published: January 2024

ZusammenfassungDie Uveitis intermedia ist eine Entzündung, die in erster Linie den Glaskörper betrifft, häufig mit assoziierter retinaler Vaskulitis. Sie tritt tendenziell bei jüngeren Patienten auf, kommt aber bis ins hohe Alter vor. Etwa 20 % der Uveitisfälle in Tertiärzentren sind intermediäre Uveitiden. Die häufigsten assoziierten Erkrankungen sind multiple Sklerose (11 %) und Sarkoidose (8 %). In 60 % der Fälle ist die Entzündung idiopathisch, und nur 1 % sind infektiös. Die Behandlung besteht aus Steroiden (systemisch, parabulbär, intravitreal) als Ersttherapie, aber wegen der häufig hartnäckigen Entzündung sind oft steroidsparende Medikamente im Sinne einer Immunsuppression nötig. Trotz des oft chronischen Verlaufs ist die Prognose einer Uveitis intermedia relativ gut.
Predicting the primary infection source of Escherichia coli bacteremia using virulence-associated genes
Authors: Ilsby Christian Schaadt , Hertz Frederik Boetius , Westh Henrik , Monk Jonathan , Worning Peder , Johansen Helle Krogh , Hansen Katrine Hartung , Pinholt Mette 
Published: January 2024

Abstract
Purpose
To investigate the role of E. coli virulence-associated genes (VAGs) in predicting urinary tract infection (UTI) as the source of bacteremia in two distinct hospital populations, one with a large general catchment area and one dominated by referrals.

Methods
E. coli bacteremias identified at Department of Clinical Microbiology (DCM), Hvidovre Hospital and DCM, Rigshospitalet in the Capital Region of Denmark from October to December 2018. Using whole genome sequencing (WGS), we identified 358 VAGs from 224 E. coli bacteremia. For predictive analysis, VAGs were paired with clinical source of UTI from local bacteremia databases.

Results
VAGs strongly predicting of UTI as primary infection source of bacteremia were primarily found within the pap gene family. papX (PPV 96%, sensitivity 54%) and papGII (PPV 93%, sensitivity 56%) were found highly predictive, but showed low sensitivities. The strength of VAG predictions of UTI as source varied significantly between the two hospital populations. VAGs had weaker predictions in the tertiary referral center (Rigshospitalet), a disparity likely stemming from differences in patient population and department specialization.

Conclusion
WGS data was used to predict the primary source of E. coli bacteremia and is an attempt on a new and different type of infection source identification. Genomic data showed potential to be utilized to predict the primary source of infection; however, discrepancy between the best performing profile of VAGs between acute care hospitals and tertiary hospitals makes it difficult to implement in clinical practice.