bluuebunny/crossref_metadata_2025_split huggingface dataset:
Looking back into the future of psychoanalysis: A second chance
Authors: Jiménez Juan Pablo 
Published: November 2023

AbstractDuring the twentieth century took place a “battle of paradigms” involving all disciplines that inform Psychiatry and Psychology. Basically, the dispute was about the respective contribution of science and hermeneutics in disciplinary paradigms. Psychoanalysis has not been absent from this battle; it is still debated whether psychoanalysis should be considered a scientific discipline or a hermeneutic discipline. In this paper, the author reviews his 40‐year career as a university professor of psychiatry and as a psychoanalyst, during which he has been a committed observer and active participant of psychoanalytic and psychiatric disputes. He reflects on how he lived this gap in Psychiatry and Psychoanalysis, and how he sees the future of Psychoanalysis under the light of new emerging epistemological frameworks.
Looking back over the shoulder: New insights on the unique scapular anatomy of the tapir (Perissodactyla: Tapiridae)
Authors: MacLaren Jamie A. 
Published: November 2023

AbstractThe musculoskeletal anatomy of the shoulder of many ungulates has been inferred from veterinary model taxa, with uniformity in muscle arrangements and attachment sites often assumed. In this study, I investigated the muscular and osteological anatomy of tapirs and their relatives (Perissodactyla: Tapiroidea), using a combination of gross dissection and digital imaging (photography and laser surface scanning). Dissections of three modern tapir species revealed that the m. infraspinatus originates from both supraspinous and infraspinous fossae for all species, lying on both sides of the distal scapular spine. The epimysial border between the m. supraspinatus and m. infraspinatus origin sites are marked in all species by an ossified ridge, sometimes extending the length of the scapular spine. This “supraspinous ridge” is clearly visible on the scapular surface of both modern and extinct Tapirus scapulae; however, the ridge does not appear present in any non‐Tapirus tapiroids examined (e.g., Helaletes, Nexuotapirus), nor in other perissodactyls or artiodactyls. Moreover, the ridge exhibits a clearly distinct morphology in Tapirus indicus compared to all other Tapirus species examined. Combined, these findings indicate that the presence and position of the “supraspinous ridge” may represent a robust phylogenetic character for reconstructing relationships within tapiroids. Unfortunately, any functional locomotor outcomes or benefits of the m. infraspinatus straddling the scapular spine remains elusive. This study represents a firm reminder for anatomists, veterinarians, and paleontologists to (where possible) look beyond veterinary model systems when inferring musculoskeletal form or function in non‐model organisms.
Carbones – A Classification on the Magnetic Criterion
Authors: Kleinpeter Erich , Koch Andreas 
Published: November 2023

AbstractCarbones (carbodiphosphoranes, bent allenes and chalcogen‐stabilized carbones) bear the same resonance contributor X+−C2−−Y+ (X+, Y+=PR3+, CR2+, SR2+, SeR2+, S+R2=NR) and exhibit unique bonding and donating properties at the central carbon atom. A classification is given on basis of both the geometry and the magnetic properties (13C chemical shift of the central carbon atom and the spatial magnetic properties, through‐space NMR shieldings (TS NMRSs), actually the anisotropy effect or the ring current effect of aromatic species). TS NMRS values have been calculated using the GIAO perturbation method employing the nucleus independent chemical shift (NICS) concept and the results visualized as iso‐chemical‐shielding surfaces (ICSS) of various size and direction. The synergy of geometry (linear or bent, orthogonal or twisted structures) and NMR characteristics (extend of the high field shift of the central carbon atom, anisotropy effect of the allene‐like C=C double bonds or the ball‐like anisotropy effect of carbone‐like central carbon atom) provides a comprehensive picture of the dominating resonance contributor.
Inhibition of USP21 leads to ovarian carcinoma cell death by suppressing MAPK signaling
Authors: Sun Xin , Yu Jia , Cui Xiaorong , Tang Yujie , Yu Yani 
Published: November 2023

AbstractOvarian cancer is the most aggressive and lethal of all gynecologic malignancies. Although the overexpression (OE) of ubiquitin‐specific peptidase 21 (USP21) has been observed in multiple cancers, its expression profile and biological function in ovarian cancer remain unknown. The expression levels of USP21 in ovarian cancer cells and tissues as well as adjacent normal tissues were assessed by qRT‐PCR or Western blot assay. The biological function of USP21 in ovarian cancer cells was assessed by cell growth assay in vitro and a tumor growth model in vivo. Our study revealed that USP21 was markedly elevated in ovarian carcinoma tissues compared with adjacent normal tissues. Downregulation of USP21 attenuated the expression levels of MEK2 and p‐ERK1/2. Depletion of USP21 resulted in suppressed cell growth of ovarian cancers in vitro and inhibited tumor growth in vivo. Conversely, OE of USP21 promoted the cell proliferation of ovarian cancers and conferred resistance to BAY 11‐7082. These findings provide evidences supporting the notion of USP21 as a promising therapeutic target for the treatment of ovarian cancer.
Bausteine zu einer Oral History der Wissenschaftsgeschichte Interview mit Dieter Hoffmann
Authors: Grote Mathias , te Heesen Anke , Hoffmann Dieter 
Published: November 2023

AbstractWie kann man einen historischen Blick auf das eigene Fach werfen? Diese Frage ist nicht einfach zu beantworten – will man einerseits nicht in einer Nabelschau und Hagiographie enden, andererseits aber auch keinen umfassenden Entwurf einer zukünftigen Historiographie vorlegen. Die hier in loser Folge publizierten Interviews mit bekannten Protagonist:innen der Berliner Wissenschaftsgeschichte von ca. 1970–1990 in West und Ost rücken die Geschichte des Faches deshalb in einem bestimmten Milieu in den Fokus und versuchen, die Historiographie jenseits einer Institutionen‐ oder Theoriegeschichte voranzutreiben. Welche Motivationen oder Probleme bewegten einzelne Wissenschaftler:innen, sich der Geschichte ihres Faches zu widmen oder sich etwa aus der Soziologie oder Philosophie in die Wissenschaftsgeschichte zu bewegen? Welche Ausbildungspraktiken existierten in diesem heterogenen, zwischen den Disziplinen angesiedelten Feld, welche Anregungen bezog man aus welchen Kontexten? Wie war Lehre strukturiert und welche Netzwerke bildeten sich mit der Zeit? Kurz: Mit welchem Interesse kam man zur Wissenschaftsgeschichte und was wurde daraus?Die Auswahl der Interviewees erfolgt ohne Anspruch auf Vollständigkeit oder Proporz; der Fragenkatalog der Interviews richtet sich individuell nach den Biographien und dem Werk und entfaltet sich oft spontan im Gespräch. Die Interviews wurden digital aufgezeichnet, transkribiert, der Schriftsprache angepasst, gegebenenfalls gekürzt, annotiert und von den Interviewees authentifiziert.Wir beabsichtigen mit dieser Serie von Interviews zunächst die Dokumentation rezenter Geschichte durch eine Oral History, die subjektive Wahrnehmungen und persönliche Erlebnisse einschließt. Auf diese Weise werden Segmente einer größtenteils ungeschriebenen Geschichte anhand von Biographien erfahrbar und damit auch einer weiteren kritischen Bearbeitung und Integration in ein Gesamtbild zugänglich. Da uns im Zuge der jeweiligen Vorbereitung und Durchführung, Transkription und Abstimmung der Interviews daran gelegen war, aus Sicht der Akteur:innen wichtige Sammelbände und Aufsätze, Monographien oder auch „graue Literatur“ zu erfassen, wird nebenbei eine kommentierte Bibliographie zur Geschichte der Wissenschaftsgeschichte entstehen. Unsere Hoffnung besteht darin, mittels dieser Sammlung mit Berlin einen fruchtbaren Raum und mit den siebziger und achtziger Jahren eine produktive Zeit des Faches jenseits von Reminiszenz oder Nostalgie zu erkunden – nicht zuletzt auch, um den Blick für gegenwärtige Herausforderungen des Faches zu schärfen.
A validated bioanalytical method for the simultaneous estimation of telmisartan and gallic acid in rat plasma samples by high‐performance thin‐layer chromatography–mass spectrometry: Application to an oral pharmacokinetic study
Authors: Pattanik Swadesh Kumar , Pradhan Kishanta Kumar 
Published: November 2023

AbstractA novel and cost‐effective high‐performance thin‐layer chromatography (HPTLC) method, combined with densitometric quantification, was developed for the biomedical analysis of telmisartan (TEL) and gallic acid (GA). Recent research indicates that when used in combination, these compounds offer improved therapeutic efficacy for the treatment of cardiovascular diseases with reduced side effects. The study focused on the simultaneous quantification and pharmacokinetic analysis of drugs in rat plasma. The separation was conducted using HPTLC silica gel 60 F254 plates with dimensions of 20 × 10 cm and a thickness of 0.2 mm. The mobile phase used for separation consisted of a mixture of ethyl acetate, methanol, chloroform, and acetic acid in the ratio of 4:2:2:0.2 (v/v). GA and TEL were analyzed using ultraviolet detection at specific wavelengths, with GA at 280 nm and TEL at 296 nm. Peak purity was assessed through spectral correlation analysis using Vision CATS software. The method underwent validation following the guidelines of the US Food and Drug Administration (US FDA). Calibration plots demonstrated linearity in the concentration range of 200–1200 ng/spot, with high correlation coefficients (R2). The retention factors (Rf) were 0.67 for TEL and 0.60 for GA. The identity of the separated compounds was further confirmed using MS, with GA having a mass‐to‐charge ratio (m/z) of 168.9 in negative mode and TEL with m/z 515.2 in positive mode. In the pharmacokinetic study, the maximum peak plasma concentration (Cmax) for GA was 899.7 ng/mL, and for TEL, it was 1013 ng/mL. The time to reach maximum concentration (Tmax) was 2 h for GA and 6 h for TEL. This simultaneous qualitative and quantitative determination of the drugs in an oral pharmacokinetic study involving Wistar rats can serve as a valuable tool for future investigations into pharmacokinetic interactions, quality control, and routine analysis of these drugs, both in their pure forms and in novel formulations.
Predictive value of 18F‐FDG PET/CT and serum tumor markers for tumor mutational burden in patients with non‐small cell lung cancer
Authors: Zhang Qian , Tao Xiuli , Yuan Pei , Zhang Zewei , Ying Jianming , Guo Lei , Li Ning , Wang Shuhang , Li Jing , Liu Ying , Guo Wei , Zhao Shijun , Wu Ning 
Published: November 2023

AbstractPurposeTo investigate the correlations between metabolic parameters (MPs) of 18F‐fluorodeoxyglucose (FDG) uptake on positron emission tomography/computed tomography (PET/CT), serum tumor markers (STMs), and tumor mutational burden (TMB) in patients with non‐small cell lung cancer (NSCLC).Materials and MethodsIn this retrospective study, we enrolled 129 patients with NSCLC (males, 78; females, 51) who underwent baseline TMB and STM tests and 18F‐FDG PET/CT scans before treatment between March 2018 and September 2022. Patients were categorized into TMB‐high (TMB ≥10 mutations/Mb; n = 27 [20.9%]) and non‐TMB‐high (TMB <10 mutations/Mb; n = 102 [79.1%]) groups. Binary logistic regression analyses were performed to determine independent predictors of TMB‐high. Univariate and multivariate linear regression analyses were performed to determine independent predictors of TMB level on a log scale. Subgroup analyses for adenocarcinoma (ADC), ADC with EGFR+, ADC with EGFR−, and squamous cell carcinoma (SCC) were performed.ResultsFor ADC, all MPs (SULpeak, SULmax, SULmean, MTV, and TLG) were significantly higher in the TMB‐high group than the non‐TMB‐high group; smoker (odds ratio [OR] = 27.08, p = 0.018), EGFR+ (OR = 0.03, p = 0.033), KRAS+ (OR = 7.98, p = 0.083), high CEA (OR = 33.56, p = 0.029), and high CA125 (OR = 13.68, p = 0.030) were independent predictors of TMB‐high; and all MPs showed significant positive linear correlations with TMB on a log scale, with SULpeak as an independent predictor. However, no significant correlation was observed for SCC.ConclusionMPs and STMs can predict the TMB level for patients with ADC, and may serve as potential substitutes for TMB with increased value and easy implementation in guiding immunotherapy through noninvasive methods.
The loss of neoantigens is an important reason for immune escape in multiple myeloma patients with high intratumor heterogeneity
Authors: Wang Yue , Xu Jiadai , Lan Tianwei , Zhou Chi , Liu Peng 
Published: November 2023

AbstractObjectivesIntratumor heterogeneity (ITH) is an important factor for clinical outcomes in patients with multiple myeloma (MM). High ITH has been proven to be a key reason for tumor immune escape and treatment resistance. Neoantigens are thought to be associated with ITH, but the specific correlation and functional basis for this remains unclear.MethodsWe study this question through the whole‐exome sequencing (WES) data from 43 high ITH newly diagnosed MM patients in our center. Mutant allele tumor heterogeneity (MATH) was conducted to quantify ITH. The cutoff value for high intratumor heterogeneity was determined by comparing MATH of different kinds of tumors. NeoPredPipe was performed to predict neoantigens and binding affinity.ResultsCompared to other tumors, MM has a relatively low tumor mutation burden but a high ITH. Patients with high MATH had significantly shorter progression‐free survival times than those with low MATH (p = 0.001). In high ITH samples, there is a decrease in strong‐binding neoantigens (p = 0.019). The loss of strong‐binding neoantigens is a key factor for insensitivity to therapy (p = 0.015). Loss of heterozygosity in HLA was not observed. In addition, patients with fewer neoantigens loss had higher rates of disease remission (p = 0.047). CD8 + T cells (p = 0.012) and NK cells (p = 0.011) decreased significantly in patients with high neoantigens loss rate. A prediction model based on neoantigens was built to evaluate the strength of immune escape.ConclusionThe loss of strong‐binding neoantigens explains why tumors with high ITH have a higher degree of immune escape and may be feasible for deciding the clinical treatment of MM.
A Lateral Flow Assay Based on Streptavidin‐biotin Amplification System with Recombinase Polymerase Amplification for Rapid and Quantitative Detection of Salmonella enteritidis
Authors: Feng Fan , Fu Qiang , Cao Fengrong , Yuan Yun , Kong Ruixue , Ji Dandan , Liu Haiyun 
Published: November 2023

AbstractSalmonella constitutes a prevalent alimentary pathogen, instigating zoonotic afflictions. Consequently, the prompt discernment of Salmonella in sustenance is of cardinal significance. Lateral flow assays utilizing colorimetric methodologies adequately fulfill the prerequisites of point‐of‐care diagnostics, however, their detection threshold remains elevated, generally permitting only qualitative discernment, an impediment to the preliminary screening of nascent pathogens. In response to this conundrum, we propose a lateral flow diagnostic predicated upon a streptavidin‐biotin amplification system with recombinase polymerase amplification engineered for the expeditious and quantitative discernment of Salmonella enteritidis. Trace nucleic acids within a sample undergo exponential amplification via recombinase polymerase amplification to a level discernable, constituting the initial signal amplification. Subsequently, along the test line (T‐line) of the lateral flow strip, the chromatic signal undergoes augmentation by securing a greater quantity of AuNPs through the magnification capacity of the streptavidin‐biotin mechanism, affecting the second signal amplification. Quantitative results are procured via smartphone capture and transferred to computer software for precise calculation of the targeted quantity. The lateral flow strip exhibits a LOD at 19.41 CFU/mL for cultured S. enteritidis. The RSD of three varying concentrations were respectively 3.74 %, 5.96 %, and 4.25 %.
A case of familial Mediterranean fever presenting with ankylosing spondylitis: A rare case‐report
Authors: Khalaji Amirreza , Jafarpour Mehdi 
Published: November 2023

Key Clinical MessageThe association of familial Mediterranean fever and ankylosing spondylitis is rare, but it is essential to consider this diagnosis in patients with a history of FMF who develop symptoms of back pain or other rheumatologic conditions.AbstractFamilial Mediterranean fever (FMF) is an inherited inflammatory disorder characterized by recurrent fever episodes, abdominal pain, and arthralgia. Ankylosing spondylitis (AS) is a chronic inflammatory disease that affects the spine's joints. The association of FMF and AS is rare. We report the case of a 22‐year‐old male patient with a history of FMF and a positive family history of FMF in his father, who presented with inflammatory back pain. The patient was found to have sacroiliitis on MRI, which is a characteristic feature of AS. The patient was negative for HLA‐B27, a genetic marker often associated with AS. This case report highlights the importance of considering AS in patients with a history of FMF who develop back pain symptoms or other rheumatologic conditions.
Hypokalemic periodic paralysis in a teenage boy after an intense period of exercise: A rare case report
Authors: Noor Sahar , Rasooly Abdul Jamil , Alikozai Sultan Mahmood , Jalalzai Tooryalai , Haidary Ahmed Maseh , Nasir Najla , Noor Sarah , Farooqi Masooma , Mansoori Husna 
Published: November 2023

Key Clinical Messages

Diagnosis of rare even can be missed due to less familiarity with the disorder.

In patients with muscle weakness, infectious causes are prioritized.

Electrolyte profile not only identifies the problem, but also prevents unnecessary workup.

AbstractIn underdeveloped countries, diagnosis of rare disorders is usually delayed due to less familiarity of the clinicians to such disorders. As a result, infectious and inflammatory causes for an ailment are prioritized as compared to non‐infectious etiologies. Hypokalemic periodic paralysis (PP) is a rare disorder, characterized by episodic muscle weakness that can rarely be associated with life‐threatening cardiac arrhythmia. A teenage Afghan boy presented to the emergency department with an acute flaccid paralysis, that started 1 h after intense exercise The weakness involved both, the upper and lower extremities. Laboratory investigations, led to the impression of hypokalemic PP, precipitated by intense exercise. Accordingly, intravenous potassium chloride infusion diluted with normal saline led to the complete resolution of paralysis as well as correction of electrocardiographic changes. The list of differential diagnosis for flaccid muscle paralysis is wide, which generally requires a extensive investigations, but in hypokalemic PP, a cardinal electrolytes profile can lead towards early diagnosis. High degree of clinical suspicion with appropriate history taking and physical examination helps with the immediate identification and management of this disorder.
Massive pulmonary embolism post sleeve gastrectomy treated with systemic thrombolytic: A case report
Authors: Moeinvaziri Nader , Sadeghi Alireza 
Published: November 2023

Key Clinical MessagePrompt diagnosis and management of massive pulmonary embolism after bariatric surgery is crucial, but thrombolytic therapy may increase the risk of complications such as anastomotic leakage and bleeding. Individualized management is needed.
Tar removal from the producer gas of a small scale downdraft gasifier using a fatty acid based, wet packed‐bed scrubber
Authors: Lotfi Samira , Ma Weiguo , Austin Kevin , Luque Luis , Littlejohns Jennifer V. , Butler James 
Published: November 2023

AbstractSmall scale gasification combined heat and power (CHP) systems offer an alternative to diesel fuelled generators for power generation in remote communities and industrial sites. Tar and particulates in the producer‐gas can damage the internal combustion engine generator and increase operation and maintenance costs. In this work, we present a novel trickle‐bed scrubber using filtered waste cooking oil as a cost effective and easy‐to‐operate gas clean‐up method for a small CHP system. The performance of the trickle‐bed scrubber was compared against a packed‐bed filter utilizing woodchips in a 20 kWth downdraft gasifier. Used‐cooking oil was selected as the solvent and woodchips as the bed‐material as these are readily available, inexpensive, and can be recycled in the gasifier as fuel. A woodchip packed‐bed filter reduced the tar and particulate matter (PM) in the producer gas from gasification of spruce chips (11% moisture) from 1.6 to 1.4 g/Nm3 and from 0.16 to 0.087 g/Nm3 respectively. The trickle‐bed scrubber was able to reduce the tar and PM in the producer gas from gasification of pinewood (8% moisture) from 1.38 to 0.28 g/Nm3, and 0.209 to 0.082 g/Nm3, respectively. Tar and PM removal efficiency improved by 60% and 29% respectively. Components such as benzene, toluene, naphthalene, and biphenylene were the major tar components. After passing the trickle‐bed, most tar was removed, with a preference for removal of multi‐ringed aromatics and gravimetric tars. Parameters such as the tar and particulate concentration, feedstock moisture content, and feedstock source affect the performance of the gas clean‐up system.
Modelling nitrogen oxide emission trends from the municipal solid waste incineration process using an adaptive bi‐directional long and short‐term memory network
Authors: Li Zhenghui , Yao Shunchun , Chen Da , Li Longqian , Lu Zhimin , Yu Zhuliang 
Published: November 2023

AbstractAccurately predicting trends in NOx emission is essential for effectively controlling pollution in municipal solid waste incineration (MSWI) power plants. However, the MSWI process exhibits notable dynamic nonlinearity, time series characteristics, and fluctuations that are distinct from those present in fossil fuel combustion processes. Therefore, the model must possess excellent capabilities in handling time series and nonlinear features while achieving adaptive updates to account for complex working conditions. To address these issues, we have developed a robust prediction model for NOx emission trends using the bi‐directional long short‐term memory (Bi‐LSTM) deep learning algorithm. This model encompasses maximum information coefficient and expert experience for input variables selection, parameter optimization using the linear inertial weight particle swarm algorithm (LDWPSO), and an adaptive update strategy based on probabilistic statistics. The prediction performance of this model was compared to that of the traditional and widely used backpropagation neural network (BPNN), extreme learning machine (ELM), and LSTM. Furthermore, we verified the adaptive update effect of the proposed model using additional data. The results demonstrate that the proposed model exhibits robust prediction and adaptive capabilities. This study's originality is presenting a satisfactory trend prediction for NOx emission from the MSWI process using an adaptive LDWPSO‐(Bi‐LSTM) model. It will be essential for the optimization and control of NOx emissions from the MSWI process.