bluuebunny/crossref_metadata_2025_split huggingface dataset:
Peer functioning difficulties may exacerbate symptoms of attention‐deficit/hyperactivity disorder and irritability over time: a temporal network analysis
Authors: Bellaert Nellia , Morreale Kristina , Tseng Wan‐Ling 
Published: October 2023

BackgroundChildren with attention‐deficit/hyperactivity disorder (ADHD) have been consistently found to experience impairments in peer functioning. Irritability is highly prevalent in children with ADHD and may worsen social impairments given the frequent temper outbursts and low frustration tolerance characterizing irritability. However, it is still unclear how ADHD and irritability symptoms interact with peer functioning difficulties over time. Assessing these temporal dynamics using a novel longitudinal approach (i.e., temporal network analysis) may reveal precise targets for intervention.MethodsThis study investigates the dynamic associations between ADHD symptoms, irritability, and peer functioning in a community sample of 739 children (ages 8–11 years, Mage = 10.06 [SD = 0.59], 47.77% females) assessed at three timepoints, 6 months apart, in a school‐based study. Parents reported their child's ADHD symptoms using the Swanson, Nolan, and Pelham Rating Scale (SNAP‐IV), and irritability symptoms using the Child Behavior Checklist (CBCL) irritability items. Children's peer functioning (i.e., peer acceptance, peer rejection, number of friendships, and victimization) was measured via peer nomination. To estimate the longitudinal associations between the variables, we built a graphical vector autoregression model for panel data.ResultsThe longitudinal network highlighted that poor peer functioning contributed to increases in symptoms over time. Specifically, (1) physical victimization predicted increases in inattention, hyperactivity, and irritability; (2) peer rejection predicted increases in inattention, which in turn predicted increases in irritability; (3) peer acceptance predicted decreases in inattention and irritability; and (4) higher numbers of mutual friendships increased inattention.ConclusionsThese results suggest that a negative social environment involving physical bullying and rejection may aggravate ADHD and irritability symptoms. Conversely, positive social interactions, such as being liked by peers, may improve inattention and irritability symptoms. Fostering social–emotional skills and positive social interactions and environments in children with ADHD and irritability may be a promising target for future interventions to reduce symptoms.
Livin' la vida local: philopatry results in consistent patterns of annual space use in a long‐lived lizard
Authors: Stalker J. B. , Jones J. L. , Hromada S. J. , Nussear K. E. , Vandergast A. G. , Wood D. A. , Tracy C. R. , Gienger C. M. 
Published: October 2023

AbstractFor animals exhibiting range residency, the home range is a useful framework to quantify space use. Some reptiles can live decades in the wild and experience extreme environmental variation that influences patterns of habitat use. Individuals may modify their use of space over time, reducing the utility of single‐year home range estimates. Very high frequency (VHF) telemetry data were collected for Gila monsters (Heloderma suspectum) at three Mojave Desert sites in Clark County, Nevada, and home range utilization distributions were calculated using an autocorrelated kernel density estimator. Home range size was consistent within individuals and populations, and home range size did not vary across years at any site. To measure home range fidelity (year‐to‐year reuse), we calculated Bhattacharyya's coefficient (BC) for each combination of years in which an individual was tracked and averaged estimates across individuals and populations. The average BC score was 0.86 (scale from 0 to 1; 0 = no overlap and 1 = complete overlap) and did not vary among populations. We modeled home range area accumulation to estimate the minimum sample size needed for asymptotic stability and found home range accumulation to be dynamic and variable within and across years and individuals. Analysis of the frequency of movement by individuals, average distance traveled per movement, and cumulative distance traveled per active season revealed that movement patterns vary considerably by year. Heterogeneity of space use among populations and individuals suggests that individual and local environmental variation, rather than annual variation in resource availability, may drive home range size and movement patterns of Gila monsters in southern Nevada. Annual variability in movement patterns did not translate to variability in home range size or location, and the species exhibits extremely high philopatry, using the same areas for periods of at least 3–5 years.
Influence of environmental settings in geographically distinct ports on the protein profiles of cultivable bacteria using MALDI–TOF mass spectrometry
Authors: Khandeparker Lidita , Gardade Laxman , Anil Arga Chandrashekar 
Published: October 2023

AbstractThe protein profiles of bacteria are useful markers in their identification. In this study, we examined the influence of environmental settings on the protein profiles of culturable bacteria using matrix‐assisted laser desorption ionization‐time of flight mass spectrometry (MALDI–TOF MS). We compared the protein profiles of bacteria collected from geographically distinct port environments (Kolkata, a freshwater port, and Kandla, a marine port) from India. The results indicated that bacterial species were distinctly different between the two ports, except for a few bacteria, that were common, such as Bacillus cereus, Enterobacter cloacae, Micrococcus luteus, Pseudomonas aeruginosa, P. putida, P. stutzeri, P. mosselii and Vibrio parahaemolyticus. Mass spectra of these common bacterial species, a few pathogenic among them, differed in their protein profiles and relative intensity of peaks. These variations point out that environmental settings/factors have a significant role in the protein expression and can result in differentiated virulence of pathogens. Identifying these risk factors is crucial in developing appropriate environmental port management practices.
Lack of host specialization despite selective host use in brood parasitic cuckoo catfish
Authors: Reichard Martin , Koblmüller Stephan , Blažek Radim , Zimmermann Holger , Katongo Cyprian , Bryjová Anna , Bryja Josef 
Published: October 2023

AbstractHost–parasite dynamics involve coevolutionary arms races, which may lead to host specialization and ensuing diversification. Our general understanding of the evolution of host specialization in brood parasites is compromised by a restricted focus on bird and insect lineages. The cuckoo catfish (Synodontis multipunctatus) is an obligate parasite of parental care of mouthbrooding cichlids in Lake Tanganyika. Given the ecological and taxonomic diversity of mouthbrooding cichlids in the lake, we hypothesized the existence of sympatric host‐specific lineages in the cuckoo catfish. In a sample of 779 broods from 20 cichlid species, we found four species parasitized by cuckoo catfish (with prevalence of parasitism of 2%–18%). All parasitized cichlids were from the tribe Tropheini, maternal mouthbrooders that spawn over a substrate (rather than in open water). Phylogenetic analysis based on genomic (ddRAD sequencing) and mitochondrial (Dloop) data from cuckoo catfish embryos showed an absence of host‐specific lineages. This was corroborated by analyses of genetic structure and co‐ancestry matrix. Within host species, parasitism was not associated with any individual characteristic we recorded (parent size, water depth), but was costly as parasitized parents carried smaller clutches of their own offspring. We conclude that the cuckoo catfish is an intermediate generalist and discuss costs, benefits and constraints of host specialization in this species and brood parasites in general.
ZmELF3.1 integrates the RA2‐TSH4 module to repress maize tassel branching
Authors: Xie Yurong , Zhao Yongping , Chen Lihong , Wang Yanli , Xue Weicong , Kong Dexin , Li Changyu , Zhou Linyu , Li Huiru , Zhao Yanfeng , Wang Baobao , Xu Miaoyun , Zhao Binbin , Bilska‐Kos Anna , Wang Haiyang 
Published: October 2023

Summary
Tassel branch number (TBN) is a key agronomic trait for adapting to high‐density planting and grain yield in maize. However, the molecular regulatory mechanisms underlying tassel branching are still largely unknown.
Here, we used molecular and genetic studies together to show that ZmELF3.1 plays a critical role in regulating TBN in maize.
Previous studies showed that ZmELF3.1 forms the evening complex through interacting with ZmELF4 and ZmLUX to regulate flowering in maize and that RA2 and TSH4 (ZmSBP2) suppresses and promotes TBN in maize, respectively. In this study, we show that loss‐of‐function mutants of ZmELF3.1 exhibit a significant increase of TBN. We also show that RA2 directly binds to the promoter of TSH4 and represses its expression, thus leading to reduced TBN. We further demonstrate that ZmELF3.1 directly interacts with both RA2 and ZmELF4.2 to form tri‐protein complexes that further enhance the binding of RA2 to the promoter of TSH4, leading to suppressed TSH4 expression and consequently decreased TBN.
Our combined results establish a novel functional link between the ELF3‐ELF4‐RA2 complex and miR156‐SPL regulatory module in regulating tassel branching and provide a valuable target for genetic improvement of tassel branching in maize.
Intraspecific variation in seed size is mediated by seed dispersal modes and animal dispersers – evidence from a global‐scale dataset
Authors: Zhang Jinyu , Wang Bo 
Published: October 2023

Summary
Seed dispersal mechanisms play a crucial role in driving evolutionary changes in seed and fruit traits. While previous studies have primarily focussed on the mean or maximum values of these traits, there is also significant intraspecific variation in them. Therefore, it is pertinent to investigate whether dispersal mechanisms can explain intraspecific variations in these traits.
Taking seed size as a case study, we compiled a global dataset comprising 3424 records of intraspecific variation in seed size (IVSS), belonging to 691 plant species and 131 families. We provided the first comprehensive quantification of dispersal mechanism effects on IVSS.
Biotic‐dispersed species exhibited a larger IVSS than abiotic‐dispersed species. Synzoochory species had a larger IVSS than endozoochory, epizoochory, and myrmecochory species. Vertebrate‐dispersed species exhibited a larger IVSS than invertebrate‐dispersed species, and species dispersed by birds exhibited a larger IVSS than mammal‐dispersed species. Additionally, a clear negative correlation was detected between IVSS and disperser body mass.
Our results prove that the IVSS is associated with the seed dispersal mechanism. This study advances our understanding of the dispersal mechanisms' crucial role in seed size evolution, encompassing not only the mean value but also the variation.
4. Painful diabetic polyneuropathy
Authors: Zuidema Xander , de Galan Bastiaan , Brouwer Brigitte , Cohen Steven P. , Eldabe Sam , Argoff Charles E. , Huygen Frank , Van Zundert Jan 
Published: October 2023

AbstractIntroductionPain as a symptom of diabetic polyneuropathy (DPN) significantly lowers quality of life, increases mortality and is the main reason for patients with diabetes to seek medical attention. The number of people suffering from painful diabetic polyneuropathy (PDPN) has increased significantly over the past decades.MethodsThe literature on the diagnosis and treatment of diabetic polyneuropathy was retrieved and summarized.ResultsThe etiology of PDPN is complex, with primary damage to peripheral nociceptors and altered spinal and supra‐spinal modulation. To achieve better patient outcomes, the mode of diagnosis and treatment of PDPN evolves toward more precise pain‐phenotyping and genotyping based on patient‐specific characteristics, new diagnostic tools, and prior response to pharmacological treatments. According to the Toronto Diabetic Neuropathy Expert Group, a presumptive diagnosis of “probable PDPN” is sufficient to initiate treatment. Proper control of plasma glucose levels, and prevention of risk factors are essential in the treatment of PDPN. Mechanism‐based pharmacological treatment should be initiated as early as possible. If symptomatic pharmacologic treatment fails, spinal cord stimulation (SCS) should be considered. In isolated cases, where symptomatic pharmacologic treatment and SCS are unsuccessful or cannot be used, sympathetic lumbar chain neurolysis and/or radiofrequency ablation (SLCN/SLCRF), dorsal root ganglion stimulation (DRGs) or posterior tibial nerve stimulation (PTNS) may be considered. However, it is recommended that these treatments be applied only in a study setting in a center of expertise.ConclusionsThe diagnosis of PDPN evolves toward pheno‐and genotyping and treatment should be mechanism‐based.
DGW1, encoding an hnRNP‐like RNA binding protein, positively regulates grain size and weight by interacting with GW6 mRNA
Authors: Li Lingfeng , Li Jijin , Liu Keke , Jiang Chenglong , Jin Wenhu , Ye Jiangkun , Qin Tierui , Luo Binjiu , Chen Zeyu , Li Jinzhao , Lv Fuxiang , Li Xiaojun , Wang Haipeng , Jin Jinghua , Deng Qiming , Wang Shiquan , Zhu Jun , Zou Ting , Liu Huainian , Li Shuangcheng , Li Ping , Liang Yueyang 
Published: October 2023

SummaryGrain size and weight determine rice yield. Although numerous genes and pathways involved in regulating grain size have been identified, our knowledge of post‐transcriptional control of grain size remains elusive. In this study, we characterize a rice mutant, decreased grain width and weight 1 (dgw1), which produces small grains. We show that DGW1 encodes a member of the heterogeneous nuclear ribonucleoprotein (hnRNP) family protein and preferentially expresses in developing panicles, positively regulating grain size by promoting cell expansion in spikelet hulls. Overexpression of DGW1 increases grain weight and grain numbers, leading to a significant rise in rice grain yield. We further demonstrate that DGW1 functions in grain size regulation by directly binding to the mRNA of Grain Width 6 (GW6), a critical grain size regulator in rice. Overexpression of GW6 restored the grain size phenotype of DGW1‐knockout plants. DGW1 interacts with two oligouridylate binding proteins (OsUBP1a and OsUBP1b), which also bind the GW6 mRNA. In addition, the second RRM domain of DGW1 is indispensable for its mediated protein‐RNA and protein–protein interactions. In summary, our findings identify a new regulatory module of DGW1‐GW6 that regulates rice grain size and weight, providing important insights into the function of hnRNP‐like proteins in the regulation of grain size.
Efficacy of using oral methotrexate with phototherapy in the treatment of vitiligo in comparison with single phototherapy treatment: A double‐blinded randomized controlled trial
Authors: Lajevardi Vahide , Hosseini Zahra Sadat Seyed , Heidari Sama 
Published: October 2023

AbstractBackgroundVitiligo is an acquired skin disease with a worldwide prevalence of 0.5%–2% and a tendency to involve both genders. Although the exact pathologic mechanism is unknown, there is some evidence for the role of autoimmunity in this disease. Based on this theory, various immunosuppressive agents, such as topical or systemic corticosteroids and phototherapy (including narrowband ultraviolet B), are used. Methotrexate is another immunosuppressant that has recently become popular as a single treatment for vitiligo; however, the synergistic effect and its superiority over other treatments are two crucial factors that are still obscure. This study aimed to compare the efficacy of methotrexate+ NB‐UVB versus placebo+ NB‐UVB in vitiligo patients.MethodsIn this double‐blinded, randomized controlled trial, 42 patients were randomly allocated into two groups: the first group received three times weekly NB‐UVB plus placebo, and the second group was treated with three times weekly NB‐UVB in combination with a weekly dose of 12.5 mg MTX. The total duration of treatment was 6 months, patients were followed up every 2 months, and the assessment tools were VASI (repigmentation indicator) and VIDA (disease activity indicator) scores.ResultsBoth treatment groups showed improvement in VASI and VIDA scores during 6‐month follow‐up, but no statistical significance was found between the two treatment methods.ConclusionThis study demonstrated that both treatment modalities were equally effective, and further studies are required to evaluate the efficacy of MTX with other medications with longer follow‐up and a larger sample size.
Type of infertility and prevalence of congenital malformations
Authors: Basso Olga , Shapiro Gabriel D. , Gagnon Robert , Tamblyn Robyn , Platt Robert W. 
Published: October 2023

AbstractBackgroundChildren conceived with assisted reproductive technologies (ART) or after a long waiting time have a higher prevalence of congenital malformations, but few studies have examined the contribution of type of infertility.ObjectivesTo quantify the association between causes of infertility and prevalence of malformations.MethodsWe compared the prevalence at birth of all and severe malformations diagnosed up to age 2 between 6656 children born in 1996–2017 to parents who had previously been assessed for infertility a an academic fertility clinic (“exposed”) and 10,382 children born in the same period to parents with no recent medical history of infertility (“reference”). We estimated prevalence ratios (PR) and prevalence differences (PD), by infertility status, type of treatment (non‐ART, ART), and infertility diagnosis, in all children and among singletons.ResultsCompared with children of parents with no infertility, children of parents with infertility had a higher prevalence of malformations (both definitions), particularly following ART conceptions. After accounting for treatment, ovulatory disorders were associated with a higher prevalence of both all (PR 1.49, 95% confidence interval (CI) 1.15, 1.93; PD 3.8, 95% CI 1.0, 6.6) and severe (PR 1.53, 95% CI 1.02, 2.29; PD 1.8, 95% CI −0.2, 3.7) malformations (the estimates refer to exposed children conceived without treatment). Unexplained and male factor infertility were associated with all and severe malformations, respectively. Estimates among singletons were similar. A diagnosis of ovulatory disorders was associated with all malformations also in analyses restricted to exposed children, regardless of treatment (we did not examine severe malformations, due to limited power).ConclusionsIn this study, ovulatory disorders were consistently associated with a higher prevalence of congenital malformations (including severe malformations) among live births, regardless of mode of conception.
Concentration of suspended solids in superintensive culture of the Pacific white shrimpLitopenaeus vannameiwith biofloc technology (BFT): A review
Authors: Schveitzer Rodrigo , Baccarat Roberto Fábio Conway , Gaona Carlos Augusto Prata , Wasielesky Wilson , Arantes Rafael 
Published: October 2023

AbstractMicrobial flocs (bioflocs) present in the water of intensive culture tanks are formed by a variety of microorganisms and other kinds of particulate organic matter, such as faeces and uneaten feed. During shrimp culture, biofloc concentrations increase. It has been reported that some level of control over biofloc levels, which can be quantified by the concentration of total suspended solids (TSS), is necessary for the adequate performance of the system. Some authors suggest that TSS concentrations below 600 mg L−1are more appropriate for the superintensive culture of the Pacific white shrimpLitopenaeus vannameiin biofloc technology (BFT). However, subsequent research results contradict some of the arguments supporting the suggested solids limits, for example, the impact of increased solids on gill obstruction and subsequent shrimp survival. Recent studies have also shown the relationship between the control of solids and other important aspects of the system not considered so far, such as the control of opportunistic bacteria. Therefore, this topic seems worthy of revisiting, and it will be helpful to find new guidance toward understanding the levels of bioflocs that should be kept inL. vannameiculture tanks. In this review, we addressed the reasons that led to the establishment and limitations of the current biofloc levels forL. vannameiculture. The effects of maintaining low and high levels of bioflocs on both shrimp performance and the culture system are also analysed. Finally, perspectives on the management of biofloc levels are discussed, highlighting the advantages and disadvantages of each proposed strategy.
Mechanisms underlying the health benefits of intermittent hypoxia conditioning
Authors: Burtscher Johannes , Citherlet Tom , Camacho‐Cardenosa Alba , Camacho‐Cardenosa Marta , Raberin Antoine , Krumm Bastien , Hohenauer Erich , Egg Margit , Lichtblau Mona , Müller Julian , Rybnikova Elena A. , Gatterer Hannes , Debevec Tadej , Baillieul Sebastien , Manferdelli Giorgio , Behrendt Tom , Schega Lutz , Ehrenreich Hannelore , Millet Grégoire P. , Gassmann Max , Schwarzer Christoph , Glazachev Oleg , Girard Olivier , Lalande Sophie , Hamlin Michael , Samaja Michele , Hüfner Katharina , Burtscher Martin , Panza Gino , Mallet Robert T. 
Published: October 2023

AbstractIntermittent hypoxia (IH) is commonly associated with pathological conditions, particularly obstructive sleep apnoea. However, IH is also increasingly used to enhance health and performance and is emerging as a potent non‐pharmacological intervention against numerous diseases. Whether IH is detrimental or beneficial for health is largely determined by the intensity, duration, number and frequency of the hypoxic exposures and by the specific responses they engender. Adaptive responses to hypoxia protect from future hypoxic or ischaemic insults, improve cellular resilience and functions, and boost mental and physical performance. The cellular and systemic mechanisms producing these benefits are highly complex, and the failure of different components can shift long‐term adaptation to maladaptation and the development of pathologies. Rather than discussing in detail the well‐characterized individual responses and adaptations to IH, we here aim to summarize and integrate hypoxia‐activated mechanisms into a holistic picture of the body's adaptive responses to hypoxia and specifically IH, and demonstrate how these mechanisms might be mobilized for their health benefits while minimizing the risks of hypoxia exposure.
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