bluuebunny/crossref_metadata_2025_split huggingface dataset:
Ein Mapping Review zu Qualität in Organisationen der Weiterbildung. Perspektiven für die Erforschung organisationsinterner Koordinationsprozesse bei der Entwicklung von Qualität
Authors: Jenner Annabel 
Published: November 2023

ZusammenfassungOrganisationen der Weiterbildung sind mit zunehmenden Qualitätsanforderungen konfrontiert. Die Weiterbildungsforschung hat darauf bislang besonders unter Perspektiven der Koordination und Steuerung Bezug genommen. Demgegenüber ist der Bedeutung regulatorischer Einflüsse für die operative Entwicklung von Qualität durch die Mitarbeitenden in Weiterbildungsorganisationen weniger Aufmerksamkeit zuteilgeworden. Der Beitrag gibt anhand eines Mapping Reviews einen Überblick über den aktuellen Diskurs zu Qualität in Organisationen der Weiterbildung. Entlang von sechs Themensträngen verdeutlichen die Befunde zentrale Schwerpunkte. Zugleich bieten die Befunde erste Anhaltspunkte für das Verständnis organisationsinterner Handlungskoordination bei der Entwicklung von Qualität. Unter der Perspektive der Educational-Governance-Forschung werden diese Anhaltspunkte für künftige Forschung weiterentwickelt. Im Ergebnis stehen Vorschläge, die den Qualitätsdiskurs im Hinblick auf eine verschränkte Auseinandersetzung mit Steuerungsphänomenen auf der Makroebene und binnenorganisatorischen Prozessen der Qualitätsentwicklung voranbringen.
Nonlinear time-history analysis of the Evolution Tower resting on cellular raft due to earthquake loads
Authors: Shaaban Mohammed , Abouelsaad Mohamed Naguib , El Bagalaty Salah , El Madawy Mohamed E. 
Published: November 2023

AbstractThis study includes an investigation of using a cellular raft over piles on the seismic response of both a twisting and regular tower using the direct method, demonstrating the variance between a solid raft and a cellular raft. Both towers are 52 stories high and made of reinforced concrete. They were also built on a reinforced concrete piled-raft foundation. The soil model is thought to be multi-layered and has the same profile as the zone under investigation (New Mansoura, Egypt). All structural properties (dimensions, section properties, materials) are equal to allow a fair comparison of output response for both towers. The sole difference between the two towers is their elevation. The study is carried out under seismic loads using nonlinear time-history analysis. All analyses are carried out employing finite-element software (Midas GTS NX). Thus, seven distinct earthquake records with full 3D models were used for time-history research. According to the findings and discussions, it is concluded that adopting a cellular raft can reduce the dynamic response of the towers. Considering the soil–structure interaction, the maximum inter-story drift ratio decreases by 8.17% for the twisting tower and 5.58% for the regular tower while using the cellular raft. Furthermore, the regular tower is more effective than the twisting tower at resisting lateral loads.
Active mobility and mental health: A scoping review towards a healthier world
Authors: Scrivano Luana , Tessari Alessia , Marcora Samuele M. , Manners David N. 
Published: November 2023

Abstract
Research has proven that engaging in active mobility (AM), namely walking and cycling for transportation, significantly enhances physical activity levels, leading to better physical health. It is still unclear whether AM could also offer any mental health benefits. This scoping review aims to provide a comprehensive understanding of the current knowledge on the relationship between AM and mental health, given its crucial role in public health. The authors searched online databases to isolate primary studies written in English involving an adult sample (16 or over). AM was the exposure factor. Many mental health elements were included as outcomes (depression, anxiety, self-esteem, self-efficacy, stress, psychological and subjective well-being, resilience, loneliness and social support, quality of life, mood, life satisfaction and sleep). The results were organised in a narrative summary per each outcome selected, graphical syntheses and an overview of gaps to be further examined. The authors identified a total of 55 papers as relevant. The results show inconsistency in study designs, definition and operationalisation of the variables, approach and methodologies used. A cross-sectional design was the dominant choice, primarily examining data from national public health surveys. Nonetheless, there has been improvement in outcomes of interests, initially mainly the quality of life and affect. Lately, authors have focused on a broader range of mental health-related factors (such as travel satisfaction). The experimental studies showed promising mental health improvements in those who used active modes more than those who used motorised vehicles. It creates a rationale for further research towards implementing a unified theoretical and methodological framework to study the link between AM and mental health. The ultimate goal is to generate solid conclusions that could support building societies and cities through public health promotion and sustainable strategies, like walking and cycling as a means of transport.
Marx, Malthus, and the Moral Economy of Reproduction
Authors: Cicerchia Lillian 
Published: November 2023

AbstractThis article examines the “backlash thesis” as a way of interpreting hostility and resistance to reproductive rights in the United States. The dominant interpretation of resistance to abortion rights or of advocacy for population control is that they are a backlash against feminism and civil rights. Granting that the backlash thesis has intuitive appeal, the article argues that it is not adequate to a contemporary analysis of these issues. It then claims that what is needed is an account of the contradictory and dynamic way in which capitalism generates anxiety about fertility and family life. The article then uses socialist feminist social reproduction theory to develop an alternative explanatory framework for why market forces form the precondition and basis for context-specific appeals to tradition rather than being antithetical to them. The latter includes both pronatalist ideas and neo-Malthusian ones about population control. The article concludes by suggesting ways in which the analysis can be useful in other contexts.
Kantian Circularity: Maimon on Causal Scepticism and the Status of the Hypothetical Judgement
Authors: Fitton Emily 
Published: November 2023

AbstractA key theme throughout Maimon’s works is a circularity he diagnoses at the heart of Kant’s response to Hume. The objective validity of Kant’s category of causality ultimately rests, Maimon argues, upon the logical status of the hypothetical judgement – on its inclusion among the forms of pure general logic. In turn, however, the inclusion of the hypothetical within pure general logic itself rests upon the objective validity of causal judgements. This article examines Maimon’s diagnosis and traces it back to a debate that has its origins in Wolff’s German Logic, concerning the relationship between categorical and hypothetical judgements.
Discrimination reported by people with schizophrenia: cross-national variations in relation to the Human Development Index
Authors: Gronholm P. C. , Ali S. , Brohan E. , Thornicroft G. 
Published: November 2023

Abstract

Aims
Mental health related stigma and discrimination is a universal phenomenon and a contributor to the adversity experienced by people with schizophrenia. Research has produced inconsistent findings on how discrimination differs across settings and the contextual factors that underpin these differences. This study investigates the association between country-level Human Development Index (HDI) and experienced and anticipated discrimination reported by people with schizophrenia.

Methods
This study is a secondary data analysis of a global cross-sectional survey completed by people living with schizophrenia across 29 countries, between 2005 and 2008. Experienced and anticipated discrimination were assessed using the Discrimination and Stigma Scale (DISC-10). Countries were classified according to their 2006 HDI. Negative binomial and Poisson regression analyses with a robust standard errors approach were conducted to investigate associations between country-level HDI and discrimination.

Results
In the regression analyses, no evidence was found for a linear association between HDI and experienced or anticipated discrimination. Further exploratory analyses showed a significant non-linear association between HDI ratings and experienced discrimination. Participants in “high” and “very high” HDI countries reported more experienced discrimination compared to those in “medium” HDI countries.

Conclusions
HDI does, to some extent, appear to be associated with how far discrimination is experienced across different contexts. More high-quality cross-national research, including research focused on “medium” and “low” countries, is needed to substantiate these findings and identify underlying factors that may explain the pattern observed for experienced discrimination, including generating new datasets that would enable for these analyses to be repeated and contrasted with more recent data. An in-depth understanding of these factors will further aid the adaptation of cross-cultural and context specific anti-stigma interventions in future.
Impact of Climate Change on Water Sources and River‐Floodplain Mixing in the Natural Wetland Floodplain of Biebrza River
Authors: Berezowski Tomasz , Partington Daniel 
Published: November 2023

AbstractThe origins of river and floodplain waters (groundwater, rainfall, and snowmelt) and their extent during overbank flow events strongly impact ecological processes such as denitrification and vegetation development. However, the long‐term sensitivity of floodplain water signatures to climate change remains elusive. We examined how the integrated hydrological model HydroGeoSphere and the Hydraulic Mixing‐Cell method could help us understand the long‐term impact of climate change on water signatures and their spatial distribution in the protected Biebrza River Catchment in northeastern Poland. Our model relied on 20th century Reanalysis Data from 1881 to 2015 and an ensemble of EURO‐CORDEX simulations for representative concentration pathways (RCP) 2.6, 4.5, and 8.5 from 2006 to 2099. The historical component of the simulations was subjected to extensive multiple‐variable validation from 1881 to 2019. The results show that the extents of water sources were rather stable in the floodplain in the 1881–2015 period. The projected future impacts were variable with each analyzed RCP, but in all cases, different significant trends were present for the spatial distribution of water sources and for the river‐floodplain mixing. However, the total volume of water from different sources was less sensitive to climate change than the dominant sources and spatial distribution of water. The simulation results highlight the impact of climate change on the extent of water sources in temperate zone wetlands with significant implications for ecological processes and management. These results also underscore the urgent need to leverage such modeling studies to inform protective and preservation strategies of floodplain wetlands.
Antibody-directed evolution reveals a mechanism for enhanced neutralization at the HIV-1 fusion peptide site
Authors: Banach Bailey B. , Pletnev Sergei , Olia Adam S. , Xu Kai , Zhang Baoshan , Rawi Reda , Bylund Tatsiana , Doria-Rose Nicole A. , Nguyen Thuy Duong , Fahad Ahmed S. , Lee Myungjin , Lin Bob C. , Liu Tracy , Louder Mark K. , Madan Bharat , McKee Krisha , O’Dell Sijy , Sastry Mallika , Schön Arne , Bui Natalie , Shen Chen-Hsiang , Wolfe Jacy R. , Chuang Gwo-Yu , Mascola John R. , Kwong Peter D. , DeKosky Brandon J. 
Published: November 2023

AbstractThe HIV-1 fusion peptide (FP) represents a promising vaccine target, but global FP sequence diversity among circulating strains has limited anti-FP antibodies to ~60% neutralization breadth. Here we evolve the FP-targeting antibody VRC34.01 in vitro to enhance FP-neutralization using site saturation mutagenesis and yeast display. Successive rounds of directed evolution by iterative selection of antibodies for binding to resistant HIV-1 strains establish a variant, VRC34.01_mm28, as a best-in-class antibody with 10-fold enhanced potency compared to the template antibody and ~80% breadth on a cross-clade 208-strain neutralization panel. Structural analyses demonstrate that the improved paratope expands the FP binding groove to accommodate diverse FP sequences of different lengths while also recognizing the HIV-1 Env backbone. These data reveal critical antibody features for enhanced neutralization breadth and potency against the FP site of vulnerability and accelerate clinical development of broad HIV-1 FP-targeting vaccines and therapeutics.
Targetable lesions and proteomes predict therapy sensitivity through disease evolution in pediatric acute lymphoblastic leukemia
Authors: Lorentzian Amanda C. , Rever Jenna , Ergin Enes K. , Guo Meiyun , Akella Neha M. , Rolf Nina , James Lim C. , Reid Gregor S. D. , Maxwell Christopher A. , Lange Philipp F. 
Published: November 2023

AbstractChildhood acute lymphoblastic leukemia (ALL) genomes show that relapses often arise from subclonal outgrowths. However, the impact of clonal evolution on the actionable proteome and response to targeted therapy is not known. Here, we present a comprehensive retrospective analysis of paired ALL diagnosis and relapsed specimen. Targeted next generation sequencing and proteome analysis indicate persistence of actionable genome variants and stable proteomes through disease progression. Paired viably-frozen biopsies show high correlation of drug response to variant-targeted therapies but in vitro selectivity is low. Proteome analysis prioritizes PARP1 as a pan-ALL target candidate needed for survival following cellular stress; diagnostic and relapsed ALL samples demonstrate robust sensitivity to treatment with two PARP1/2 inhibitors. Together, these findings support initiating prospective precision oncology approaches at ALL diagnosis and emphasize the need to incorporate proteome analysis to prospectively determine tumor sensitivities, which are likely to be retained at disease relapse.
Reduced FOXF1 links unrepaired DNA damage to pulmonary arterial hypertension
Authors: Isobe Sarasa , Nair Ramesh V. , Kang Helen Y. , Wang Lingli , Moonen Jan-Renier , Shinohara Tsutomu , Cao Aiqin , Taylor Shalina , Otsuki Shoichiro , Marciano David P. , Harper Rebecca L. , Adil Mir S. , Zhang Chongyang , Lago-Docampo Mauro , Körbelin Jakob , Engreitz Jesse M. , Snyder Michael P. , Rabinovitch Marlene 
Published: November 2023

AbstractPulmonary arterial hypertension (PAH) is a progressive disease in which pulmonary arterial (PA) endothelial cell (EC) dysfunction is associated with unrepaired DNA damage. BMPR2 is the most common genetic cause of PAH. We report that human PAEC with reduced BMPR2 have persistent DNA damage in room air after hypoxia (reoxygenation), as do mice with EC-specific deletion of Bmpr2 (EC-Bmpr2-/-) and persistent pulmonary hypertension. Similar findings are observed in PAEC with loss of the DNA damage sensor ATM, and in mice with Atm deleted in EC (EC-Atm-/-). Gene expression analysis of EC-Atm-/- and EC-Bmpr2-/- lung EC reveals reduced Foxf1, a transcription factor with selectivity for lung EC. Reducing FOXF1 in control PAEC induces DNA damage and impaired angiogenesis whereas transfection of FOXF1 in PAH PAEC repairs DNA damage and restores angiogenesis. Lung EC targeted delivery of Foxf1 to reoxygenated EC-Bmpr2-/- mice repairs DNA damage, induces angiogenesis and reverses pulmonary hypertension.
The D-Mercator method for the multidimensional hyperbolic embedding of real networks
Authors: Jankowski Robert , Allard Antoine , Boguñá Marián , Serrano M. Ángeles 
Published: November 2023

AbstractOne of the pillars of the geometric approach to networks has been the development of model-based mapping tools that embed real networks in its latent geometry. In particular, the tool Mercator embeds networks into the hyperbolic plane. However, some real networks are better described by the multidimensional formulation of the underlying geometric model. Here, we introduce D-Mercator, a model-based embedding method that produces multidimensional maps of real networks into the (D + 1)-hyperbolic space, where the similarity subspace is represented as a D-sphere. We used D-Mercator to produce multidimensional hyperbolic maps of real networks and estimated their intrinsic dimensionality in terms of navigability and community structure. Multidimensional representations of real networks are instrumental in the identification of factors that determine connectivity and in elucidating fundamental issues that hinge on dimensionality, such as the presence of universality in critical behavior.
Realization of a quantum neural network using repeat-until-success circuits in a superconducting quantum processor
Authors: Moreira M. S. , Guerreschi G. G. , Vlothuizen W. , Marques J. F. , van Straten J. , Premaratne S. P. , Zou X. , Ali H. , Muthusubramanian N. , Zachariadis C. , van Someren J. , Beekman M. , Haider N. , Bruno A. , Almudever C. G. , Matsuura A. Y. , DiCarlo L. 
Published: November 2023

AbstractArtificial neural networks are becoming an integral part of digital solutions to complex problems. However, employing neural networks on quantum processors faces challenges related to the implementation of non-linear functions using quantum circuits. In this paper, we use repeat-until-success circuits enabled by real-time control-flow feedback to realize quantum neurons with non-linear activation functions. These neurons constitute elementary building blocks that can be arranged in a variety of layouts to carry out deep learning tasks quantum coherently. As an example, we construct a minimal feedforward quantum neural network capable of learning all 2-to-1-bit Boolean functions by optimization of network activation parameters within the supervised-learning paradigm. This model is shown to perform non-linear classification and effectively learns from multiple copies of a single training state consisting of the maximal superposition of all inputs.
Prevalence and factors associated with anemia in women of reproductive age across low- and middle-income countries based on national data
Authors: Alem Adugnaw Zeleke , Efendi Ferry , McKenna Lisa , Felipe-Dimog Eva Belingon , Chilot Dagmawi , Tonapa Santo Imanuel , Susanti Ika Adelia , Zainuri Agus 
Published: November 2023

AbstractAnemia is a global threat among women of reproductive age (WRA), or 15–49 years old women, both in developed and developing countries. Prevalence of anemia in WRA is higher by fourfold in developing countries, based on extensive studies and surveys conducted by WHO and UNICEF. However, there is limited studies that conducted pooled analysis of anemia prevalence in low resource countries. This study aimed to assess the prevalence and factors associated with anemia among women of reproductive age in low- and middle-income countries (LMICs). This study used secondary data from the Demographic and Health Survey (DHS) in 46 low- and middle-income countries during 2010–2021. Descriptive statistics of proportions between pregnant and non-pregnant mothers were assessed. Multilevel binary logistic regression was used to test the factors associated with anemia among women of reproductive age. A total of 881,148 women of childbearing age in LMICs were included. This study found a high prevalence of 45.20% (95% CI 41.21, 49.16) of anemia was observed in among pregnant women and 39.52% (95% CI 33.88, 45.15) anemia was observed in non-pregnant women. Educational status, wealth status, family size, media exposure, and residence were common factors significantly associated with anemia in both pregnant and non-pregnant women. The high global burden of anemia in LMICs continues to underline the need for unusual approaches and target interventions on an individual basis. Global commitment and movement to reduce the prevalence of anemia need to be revisited and redesigned for current circumstances.
Biotechnological strategies for controlled accumulation of flavones in hairy root culture of Scutellaria lateriflora L.
Authors: Wilczańska Agata , Sparzak-Stefanowska Barbara , Kokotkiewicz Adam , Jesionek Anna , Królicka Aleksandra , Łuczkiewicz Maria , Krauze-Baranowska Mirosława 
Published: November 2023

AbstractAccumulation of medicinally important flavones and acteoside was evaluated in Scutellaria lateriflora hairy root cultures subjected to different experimental strategies – feeding with precursors of phenolics biosynthesis (phenylalanine, cinnamic acid, and sodium cinnamate), addition of elicitors (chitosan, jasmonic acid) and Amberlite XAD-4 and XAD-7 resins and permeabilization with dimethyl sulfoxide (DMSO) and methanol. The production profile of S. lateriflora cultures changed under the influence of the applied strategies. Hairy roots of S. lateriflora were found to be a rich source of wogonoside or wogonin, depending on the treatment used. The addition of sodium cinnamate (1.0 mg/L) was the most effective approach to provide high production of flavonoids, especially wogonoside (4.41% dry weight /DW/; 566.78 mg/L). Permeabilization with DMSO (2 µg/ml for 12 h) or methanol (30% for 12 h) resulted in high biosynthesis of wogonin (299.77 mg/L and 274.03 mg/L, respectively). The obtained results provide new insight into the selection of the optimal growth conditions for the production of in vitro biomass with a significant level of flavone accumulation. The data may be valuable for designing large-scale cultivation systems of hairy roots of S. lateriflora with high productivity of bioactive compounds – wogonin or wogonoside.
Isatin-based spiro indolenine alkaloids from Isatis indigotica Fortune with anti-neuroinflammatory and acetylcholinesterase inhibitory effects
Authors: Bai Ming , Xi Yu-Fei , Mi Si-Hui , Yang Pei-Yuan , Lou Li-Li , Lv Tian-Ming , Zhang Xin , Yao Guo-Dong , Lin Bin , Huang Xiao-Xiao , Song Shao-Jiang 
Published: November 2023

Compounds 1a/1b are a pair of enantiomers characterized by an unprecedented 6/5/6/5/6 N,O-heterocyclic scaffold with a unique spiro[4.5] core. Compound 2 is the first 6/5/6/5/5/6 hexacyclic skeleton fused with an unexpected dispiro[4.4.0.4] system.
State monitoring of switching power supply in power system based on time series voltage waveform and image analysis
Authors: Jin Longxing , Yu Weiguo , Wang Shixiang , Li Jin , Zhang Anlong 
Published: November 2023

AbstractThe switching power supply is widely used in the secondary equipment of the power grid. The failure of the switching power supply will cause the protection device to malfunction, leading to a risk of large‐scale power failure. In this paper, a real‐time monitoring method based on only output voltage information is proposed. The experiment shows that this parameter‐reduced approach, relying only on voltage information, outperforms the existing method in detection accuracy.
Sequentially rotated loop and spiral antenna arrays with a coplanar C‐figured feedline
Authors: Hirose Kazuhide , Tsubouchi Susumu , Ito Naonoshin , Urushibata Yuya , Nakano Hisamatsu 
Published: November 2023

AbstractUsing the moment method, two array antennas are investigated to reveal the effects of different radiation elements on the array characteristics. Each array comprises four elements sequentially rotated by 90° and excited by a coplanar C‐figured feedline above the ground plane. It is found that a loop element array has a 3 dB axial ratio bandwidth of 30%, 3.3 times as wide as that of an isolated loop without an array environment. In contrast, a spiral element array shows a 3 dB gain drop bandwidth of 62% (72% for the axial ratio bandwidth, wider than that of an isolated spiral by a factor of 3.0). Almost the same factors of 3.0 and 3.3 for the spiral and loop element arrays are then compared with those in similar studies. It is found that factors are classified into three groups by feedline types. The simulated results are verified by experimental work.