bluuebunny/crossref_metadata_2025_split huggingface dataset:
Halal tourism with the family: destination – local islands of the Maldives
Authors: Adham Khairul Akmaliah , Mahmad Nasir Nadiah , Muhamad Nur Sa’adah , Sarkam Saida Farhanah , Md Ramli Raudha 
Published: January 2025

Purpose
This study aims to investigate the attributes of halal tourism with family members by exploring the experiences of Muslims who had travelled with their families to the local islands of the Maldives. This country was chosen as the context of the study as it is a destination with a fully Muslim population, which served as a normative context for studying halal tourism.

Design/methodology/approach
A basic qualitative design was adopted as the research methodology, with the data collected through in-depth interviews with the selected Muslim families.

Findings
Nine emergent themes unique to the context of halal tourism with family members extend the existing discussion on family tourism and halal tourism. Overall, halal family tourism experience is laden with Islamic family values, characterised by the dimensions of group organisation, safety, practicality, risk management as well as mutual respect and benefit between travellers and providers, and among family members. This experience leads to increased family bonding and the internalisation of Islamic values. Hence, this study highlights halal tourism with family members as a form of dignified tourism.

Originality/value
Travel with the family deserves greater academic attention due to the large market size and the distinctive nature of travel undertaken by groups of individuals bonded through familial relationships. To the best of the authors’ knowledge, this study is among the first to explore the attributes of halal tourism with family members, and the normative Islamic context of the local islands of the Maldives assisted in elucidating the emergent themes and values of this form of halal tourism with family members. Halal family tourism, as a nexus of family tourism and halal tourism, offers a huge potential of future research avenue.
Does CEO power affect the risk profile of acquiring insurance company?
Authors: Sghaier Adnene 
Published: January 2025

Purpose
This study aims to examine, on the one hand, the effect of mergers and acquisitions (M&A) on the evolution of the risk profile of insurance companies and, on the other hand, determine the impact of chief executive officer (CEO) power as well as its determinants on the evolution of the risk profile of the acquiring insurance company.

Design/methodology/approach
The analysis is based on 131 transactions between 2010 and 2022 involving European Union-based acquirers. To assess the impact of M&A on the acquiring insurance company’s risk profile (RP), the authors compare changes in the acquirer’s RP to control insurance companies. This study uses linear regression with two-stage least squares instrumental variables to examine the effect of CEO power on changes in merger-related risk.

Findings
The results indicate that M&A significantly increase the RP of the acquiring insurance company. Furthermore, CEO power, as measured by its four proxies (structural, ownership, experience and prestige), is positively correlated with an increase in the RP of the acquiring insurance company. These findings suggest that powerful CEOs tend to take on more risk during M&A transactions in the insurance sector.

Practical implications
The study’s findings can inform managerial decision-making around mergers and executive incentives. Regulators can use the insights to develop early warning systems and policies to promote financial stability. Insurance firms can enhance their own risk management by assessing the potential M&A impact and designing robust risk governance frameworks. Investors can better evaluate the risk implications of M&A and CEO influence when assessing insurance companies.

Originality/value
To the best of the author’s knowledge, this study is the first empirical investigation to introduce diverse executive power metrics to analyze the link between executive power and risk-taking in the European insurance sector, with a specific emphasis on the impact on M&A as critical investment choices.
Natural tree colonisation of organo‐mineral soils does not provide a net carbon capture benefit at decadal timescales
Authors: Housego Naomi C. , Parker Thomas C. , Street Lorna E. , Vanguelova Elena I. , Mitchell Ruth J. 
Published: January 2025

Abstract

Tree cover is often increased with the aim of increasing ecosystem carbon sequestration and mitigating climate change. However, when planting trees in ecosystems with carbon‐rich soils, soil disturbance during ground preparation can cause soil carbon losses not counteracted by tree carbon gains at the decadal timescales relevant to climate change mitigation targets. Tree establishment via natural colonisation, which does not involve soil disturbance, might prevent these soil carbon losses, but this is unknown.

We measured soil, ground vegetation, and tree carbon stocks and tree inputs along an 8 metre transect from single, native, 25‐year‐old naturally colonised trees (Pinus sylvestris or Betula spp.) onto Calluna vulgaris‐dominated moorland, at sites with carbon‐rich organo‐mineral soils in the Cairngorms, UK.

Along the transect away from the tree, organic soil carbon stocks increased from 4.0 kg C m−2 at 0.5 m, to 6.0 kg C m−2 at 8 m. Meanwhile, carbon stocks in the top 10 cm of the mineral soil horizon, 3.6 kg C m−2, did not vary. Ground vegetation carbon stocks increased only slightly, from 1.0 kg C m−2 at 0.5 m, to 1.3 kg C m−2 at 8 m. Mean carbon stock per tree was 32.4 kg, so overall, sparse natural colonisation resulted in no net ecosystem carbon gain.

Policy implications: Sparse natural colonisation of carbon‐rich soils by low biomass trees might not result in net ecosystem carbon gains at decadal timescales, and instead lead to unforeseen soil carbon losses. Soil carbon changes should be taken into account when quantifying the climate change mitigation potential of natural colonisation.
“Am I in ‘Suboptimal Health’?”: The Narratives and Rhetoric in Carving out the Grey Area Between Health and Illness in Everyday Life
Authors: Cheng Lijiaozi 
Published: January 2025

ABSTRACTThis paper examines the concept of ‘suboptimal health’ (subhealth, 亚健康), a term popularised by traditional Chinese medicine (TCM) professionals and widely used in public health discourses in China at the turn of the century. Despite criticisms of it being a commercial buzzword, subhealth provides a unique lens for individuals to articulate their health experiences concerning work and life pressures. Through virtual ethnography on Chinese social media such as Weibo and interviews, this study explores the usage and implications of subhealth in everyday life. It particularly focuses on how young Chinese people employ this concept to navigate and express health‐related issues. Drawing on Leder's concept of the lived body, as well as literature on illness narratives and the sociology of diagnosis and risk, the study argues that attention to the everyday narratives of subhealth could potentially open up a space for a greater range of narratives of embodiment and might even offer a space for collective critique in a context often dominated by individual responsibility narratives. In some cases, it also enables private and public narratives that critique lifestyle factors detrimental to health. Ultimately, this paper hints at the conceptualisation of “subhealth narratives” as a research framework.
Quantifying Bone Collagen Fingerprint Variation Between Species
Authors: Baker Andrew , Buckley Michael 
Published: January 2025

ABSTRACTCollagen is the most ubiquitous protein in the animal kingdom and one of the most abundant proteins on Earth. Despite having a relatively repetitive amino acid sequence motif that enables its triple helical structure, in type 1 collagen, that dominates skin and bone, there is enough variation for its increasing use for the biomolecular species identification of animal tissues processed or degraded beyond the amenability of DNA‐based analyses. In recent years, this has been most commonly achieved through the technique of collagen peptide mass fingerprinting (PMF) known as ZooMS (Zooarchaeology by Mass Spectrometry), applied to the analysis of tens of thousands of samples across over one hundred studies in the past decade alone. However, a robust means to quantify variation between these fingerprints remains elusive, despite being increasingly required due to the shift towards a wider range of wild fauna and those that are more distantly related from currently known sequences. This is particularly problematic in fish due to their greater sequence variation. Here we evaluate the quantification of the relative closeness of collagen fingerprints between families using ANOSIM and a modified SIMPER analysis, incorporating relative peak intensity. Our results show a clear correlation between sequence differentiation and statistical distance of PMFs, indicating that the additional complexity of type 1 collagen in fish could directly affect the efficacy of biomolecular techniques such as ZooMS. Furthermore, this multivariate statistical analysis demonstrates that PMFs in fish are substantively more distinct than those of mammalian or amphibian taxa.
Raman Spectroscopy in Cellular and Tissue Aging Research
Authors: Kim Jeong Hee , Yang Daejong , Park Seungman 
Published: January 2025

ABSTRACTThe establishment of various molecular, physiological, and genetic markers for cellular senescence and aging‐associated conditions has progressed the aging study. To identify such markers, a combination of optical, proteomic‐, and sequencing‐based tools is primarily used, often accompanying extrinsic labels. Yet, the tools for clinical detection at the molecular, cellular, and tissue levels are still lacking which profoundly hinders advancements in the specific detection and timely prevention of aging‐related diseases and pathologies. Raman spectroscopy, with its capability for rapid, label‐free, and non‐invasive analysis of molecular compositions and alterations in aging cells and tissues, holds considerable promise for in vivo applications. In this review, we present recent advancements in the application of Raman spectroscopy to the study of aging in cells and tissues. We explore the use of Raman spectroscopy and related techniques for detecting cellular aging and senescence, focusing on the molecular alterations that accompany these processes. Subsequently, we provide a review of the application of Raman spectroscopy in identifying aging‐related changes in various molecules within tissues and organs.
Comparison of the incidence of recovery agitation with two different doses of ketamine in procedural sedation: A randomized clinical trial
Authors: Türkücü Çağrı , Parlak İsmet , Kokulu Kamil , Sert Ekrem T. , Mutlu Hüseyin 
Published: January 2025

AbstractObjectivesThe objective was to compare the incidence of recovery agitation and efficacy of two different intravenous (IV) doses of ketamine (0.5 mg/kg vs. 1 mg/kg) in adult patients who presented to the emergency department (ED) requiring procedural sedation with ketamine.MethodsThis randomized, prospective clinical trial included patients aged 18–75 years who required procedural sedation with ketamine in the ED. Patients were randomized to receive IV ketamine at either 0.5 mg/kg (low dose) or 1 mg/kg (high dose). The primary outcome was the incidence of recovery agitation, assessed by the Richmond Agitation–Sedation Scale (RASS) at 5, 15, and 30 min following the procedure, in both dosage groups. Secondary outcomes included overall efficacy, sedation duration, and changes in vital signs.ResultsA total of 108 patients were enrolled in the study, 54 in each group. The median (IQR) RASS scores at 5, 15, and 30 min were −4 (−5 to −4), −1 (−1.3 to 0), and 0 (−1 to 0.5), respectively, in the low‐dose group and −4 (−5 to −4), −1 (−3 to 0), and 0 (0 to 0), respectively, in the high‐dose group. The incidence of recovery agitation was similar between the low‐ and high‐dose groups (difference 1.9%, 95% confidence interval [CI] −14.8% to 18.4%). No significant difference was observed in sedation duration between the two groups (difference 0%, 95% CI −3.0% to 4.0%). While no additional ketamine was required in the high‐dose group, four patients (7.4%) in the low‐dose group required an additional half‐dose (difference 7.4%, 95% CI −2.3% to 18.7%). Changes in vital signs were similar between the two groups.ConclusionsThere was no significant difference in recovery agitation, sedation duration, and changes in vital signs between 0.5 and 1 mg/kg IV ketamine for procedural sedation in the ED.
Revealing mitochondrial architecture and functions with single molecule localization microscopy
Authors: Jolivet Nicolas , Bertolin Giulia 
Published: January 2025

AbstractUnderstanding the spatiotemporal organization of components within living systems requires the highest resolution possible. Microscopy approaches that allow for a resolution below 250 nm include electron and super‐resolution microscopy (SRM). The latter combines advanced imaging techniques and the optimization of image processing methods. Over the last two decades, various SRM‐related approaches have been introduced, especially those relying on single molecule localization microscopy (SMLM). To develop and apply SMLM approaches, mitochondria are an ideal cellular compartment due to their size, which is below the standard diffraction limit. Furthermore, mitochondria are a dynamic yet narrow compartment, and a resolution below 250 nm is required to study their composition and multifaceted functions. To this end, several SMLM technologies have been used to reveal mitochondrial composition. However, there is still room for improvement in existing techniques to study protein–protein interactions and protein dynamics within this compartment. This review aims to offer an updated overview of the existing SMLM techniques and probes associated with mitochondria to enhance their resolution at the nanoscale. Last, it paves the way for future SMLM improvements to better resolve mitochondrial dynamics and functions.
Tasteful Play: Christian Artists, Ambiguity and the Theo‐politics of Taste
Authors: Willey Robin D. , Jervis Carolyn 
Published: January 2025

ABSTRACTÉmile Durkheim (1912) argues that art is an essential part of religious life—it ‘refreshes a spirit worn down by all that is overburdening in day‐to‐day labor’ (385). For Durkheim, making art in religious contexts is akin to sacred play. We explore how contemporary Christian artists use play, frivolity and experimentation to intentionally, and more often unintentionally, challenge, or at least, reveal various social and theo‐political dynamics within their religious communities. We will explore some of the pressures artists face to ‘fit in’ to church environments, their encounters with various arbiters of ‘taste’, and the threat that artists pose to power structures in churches that have been traditionally derived through the interpretation of text. This work is part of a multi‐sited ethnography that investigated the relationship between visual art and religious innovation in Canadian Christian communities, including 4 years of ethnographic observation and interviews in Alberta, Southern Ontario, and Grand Rapids, Michigan.
Antimicrobial Effect and Cytocompatibility After Using Different Decontamination Methods on Titanium Implant Surfaces: An In Vitro Study
Authors: Alonso‐Español Andrea , Bravo Enrique , Carrillo de Albornoz Ana , Martínez María , Doll‐Nikutta Katharina , Winkel Andreas , Stiesch Meike , Herrera David , Alonso Bettina , Sanz Mariano 
Published: January 2025

ABSTRACTAimTo evaluate in vitro the antibacterial efficacy and cytocompatibility of different implant‐decontamination methods, using both 2D and 3D peri‐implant mucosa models.MethodsFour decontamination methods [chlorhexidine (CHX), electrolytic treatment (GS), curcumin (CUR), xanthohumol (XN)] were compared in four independent experiments, three with a 2D peri‐implant mucosa model on titanium surfaces and another on a 3D peri‐implant mucosa model. These decontamination procedures were tested for their antibacterial effect using a multispecies biofilm model with Streptococcus oralis, Actinomyces naeslundii, Veillonella dispar, and Porphyromonas gingivalis for 24 h. Direct cytocompatibility evaluating the impact of the treatments on tissue cells as well as indirect cytocompatibility (colonization of treated implant surfaces by tissue cells) were also tested. Both outcomes were assessed by confocal laser scanning microscopy supported by neural networks.ResultsCHX demonstrated a strong alteration of cytocompatibility and antibacterial effect, but did not remove biofilm biomass. XN and CUR demonstrated antibacterial effect and biofilm removal action, as well as cytocompatibility. GS showed antibacterial capacity with a combination of areas completely clean of biofilm with others in which a non‐vital biofilm remained. In the 3D peri‐implant mucosa model, XN and CUR showed maintenance of the mucosa integrity after treatment, whereas CHX and GS displayed disruption in the mucosal layers.ConclusionsPhytotherapeutics (CUR and XN) were the most cytocompatible substances and showed the largest antimicrobial effect. GS displayed antibiofilm activity with a localized “bubble‐shaped effect” and impaired tissue cell morphology and integrity, compromising cytocompatibility, and CHX showed antimicrobial capacity, without reducing biofilm biomass and with altered cytocompatibility.
Utilising Free Middle Turbinate Mucosal Grafts to Reconstruct the Septal Donor Site Following Nasoseptal Flap Harvesting in Endoscopic Endonasal Approach for Sellar and Parasellar Lesions
Authors: Liu Chin‐Hsuan , Lin Tsai Shan , Huang Yu‐Wen , Yeh Chien‐Fu , Hung Li‐Ting , Lan Ming‐Ying , Wang Wei‐Hsin 
Published: January 2025

ABSTRACTIntroductionThe nasoseptal flap (NSF) has become a widely favoured choice for reconstructing skull base defects following the endoscopic endonasal approach (EEA). However, the exposed septal cartilage and bone at the donor site often require an extended duration for secondary healing. This study investigated whether the free middle turbinate (MT) mucosa grafting at the septal donor site could mitigate post‐operative nasal morbidity.MethodsWe retrospectively reviewed patients with sellar and parasellar lesions who underwent NSF harvesting in EEA between 2015 and 2023. In most cases, the MT mucosa was harvested as a free mucosal graft and placed on the exposed nasal septal donor site. The degree of septal mucosalisation and the presence of nasal crusting were assessed during follow‐up appointments.ResultsA total of 104 patients were included in this study, comprising 41 males and 63 females. All patients underwent NSF harvesting for skull base defect reconstruction and 99 patients received MT mucosa grafting at the septal donor site. The average duration for complete mucosalisation of the exposed septal cartilage with the MT graft was 38.7 days, significantly different from 59.6 days for patients without the MT graft (p < 0.0001). At the 3‐month post‐operative follow‐up, 34% of the patients with MT graft displayed no crusting compared to 20% of patients without MT graft.ConclusionsThe use of free MT mucosal grafting represents a promising technique for improving mucosalization and minimising crusting at the nasal septal donor site following the harvest of the NSF in EEA for sellar and parasellar lesions.
Clinical outcomes of a real‐world prospective study using Dexcom ONE continuous glucose monitoring in people with diabetes treated with two or more insulin injections per day
Authors: Elliott Jackie , Husband Chloe , Khadem Heydar , Nemat Hoda , Cardno Lucy , Currin Laura , Hudson Susan 
Published: January 2025

AbstractAimsThis study assessed real‐world glycaemic outcomes associated with the use of Dexcom ONE in adults with suboptimally controlled diabetes.MethodsIn this single‐site prospective study, adults with type 1 (T1D) or type 2 diabetes (T2D) taking two or more insulin injections per day initiated Dexcom ONE CGM use and attended follow‐up data collection visits after 3 and 6 months. During the study, participants received usual diabetes care. Primary outcome was a change in HbA1c at 6 months. Additional outcomes included change in participant‐reported outcomes and CGM‐derived time in glucose range 3.9–10 mmol/L (TIR), time above range >10 mmol/L (TAR), and time below range <3.9 mmol/L (TBR).ResultsThere were 110 adults enrolled [T1D (n = 34): mean age 36.6 years, 55.9% female; T2D (n = 76): mean age 54.9 years, 38.2% female]. Mean HbA1c significantly decreased from 90 mmol/mol (10.3%) to 79 mmol/mol (9.4%) at 6 months (∆‐12 mmol/mol, p < 0.001) in T1D users and from 86 mmol/mol (10.1%) to 67 mmol/mol (8.3%) in T2D users (∆‐18 mmol/mol, p < 0.001). Perception of health and diabetes distress improved at 6 months for both groups. T1D users had modest improvement in TBR. T2D users exhibited a clinically meaningful increase in TIR (∆ + 9.0%).ConclusionReal‐world Dexcom ONE use was associated with clinically significant reductions in mean HbA1c after 6 months, along with meaningful improvements in participant‐reported outcomes. CGM‐derived outcomes also improved, with the possibility of there being greater improvement than could be captured in this study. These findings support expanding access to this real‐time CGM system.
Associations between colonization with Helicobacter pylori and risk of gastrointestinal tract cancers: An umbrella review of meta‐analyses
Authors: Paiva Prudente Tiago , Mezaiko Eleazar , Nunes Pereira Oliva Henrique , Yamamoto‐Silva Fernanda Paula , Santos de Freitas Silva Brunno , Oliveira Oliva Isabela , Risch Harvey 
Published: January 2025

AbstractBackgroundSeveral studies have investigated the association between Helicobacter pylori colonization and gastrointestinal malignancies. However, inconsistent results have been found, leaving no clear consensus.Materials and MethodsUmbrella review of meta‐analyses of observational studies aiming to understand the association between Helicobacter pylori colonization and gastrointestinal cancers in humans. MEDLINE, the Cochrane Library of Systematic Reviews, EMBASE, Scopus and Google Scholar were searched from their inception to January 2025. Quality assessment was performed with the AMSTAR 2 tool. The study was registered on PROSPERO (CRD42024523832).ResultsOf 1320 records, 38 meta‐analyses were included, investigating biliary tract, colorectal, oesophageal, gastric, liver and pancreatic cancers. After dealing with primary study overlap and updating meta‐analyses with over 160 studies, Helicobacter pylori was positively associated with biliary tract [OR 2.67 (1.57–4.52)], colorectal [OR 1.40 (1.23–1.60)], gastric [OR 2.10 (1.34–3.31)], liver [OR 5.13 (3.14–8.38)] and pancreatic [OR 1.24 (1.04–1.48)] cancers, while oesophageal adenocarcinoma (EAC) was inversely associated with it [OR .58 (.46–.72)]. The cytotoxic‐associated gene A (CagA) protein was positively associated with biliary [OR 2.19 (1.07–4.50)], colorectal [OR 2.04 (1.47–2.82)], oesophageal squamous cell carcinoma [OR 1.56 (1.30–1.89)] and gastric cancers [OR 2.53 (1.94–3.30)], and inversely associated with EAC [OR .60 (.44–.81)] and pancreatic [OR .85 (.75–.97)] cancers. Our results sprout from mostly critically low‐quality meta‐analyses and moderate to high quality primary studies.ConclusionExposure to Helicobacter pylori colonization and its proteins is associated with not only gastric cancer, but also other GI tract cancers. Directionally different results may be seen when specific virulence factors/organ sites are investigated.