bluuebunny/crossref_metadata_2025_split huggingface dataset:
Synergizing IFTOPSIS and DEA for Enhanced Efficiency Analysis in Inpatient Units
Authors: Wardani Cholida Usi , Abusini Sobri , Darti Isnani 
Published: December 2023

The pursuit of efficiency in the business sector is a multifaceted endeavor, extending beyond mere cost reduction to encompass a strategic optimization of operational performance. The enhancement of efficiency is not solely for the benefit of investors or proprietors but is also a concerted effort to maximize resource utilization and minimize waste. This study introduces an integrative approach combining IFTOPSIS and DEA methodologies to deliver a robust efficiency evaluation framework.The fusion of IFTOPSIS's qualitative analysis with DEA's quantitative assessments addresses the complexity of operational performance, providing a balanced evaluation that transcends subjective bias with data-driven insights. IFTOPSIS articulates decision-makers' preferences in uncertain scenarios, assigning weights to criteria, while DEA discriminates between efficient and inefficient operational units. This confluence of methods is applied to the assessment of inpatient healthcare units—a sector that has traditionally relied on patient-centric evaluations, neglecting the comprehensive review of resource deployment. The results of this amalgamated approach reveal dimensions of operational efficiency previously unexplored, offering stakeholders a data-enriched foundation for strategic decision-making. The study's findings have significant implications for the healthcare industry, providing a template for resource evaluation that could inform policy and drive improvements in patient care services.
Innovative Multi-Criteria Decision-Making Approach for Supplier Evaluation: Combining TLF, Fuzzy BWM, and VIKOR
Authors: Arief Ikhwan , Fatrias Dicky , Jie Ferry , Armijal  
Published: December 2023

When confronted with underperforming suppliers, the need to evaluate and improve supplier performance becomes apparent. However, the inherent inaccuracies in information introduce complexity, especially when subjective human judgment is involved in the supplier evaluation process. Associated with such problem, this study presents a novel methodology for supplier performance evaluation in the crumb rubber industry, integrating the Taguchi Loss Function (TLF), fuzzy Best-Worst Method (BWM), and VIKOR technique in group decision-making environment. Aimed at addressing the challenges in industries with variable supplier quality and performance, such as the crumb rubber industry in Indonesia, the methodology was empirically tested to demonstrate its practical utility. The process involved identifying evaluation criteria through literature review tailored to the needs of decision makers (DMs), applying TLF to quantify losses from supplier performance deviations, using fuzzy BWM to determine criteria weights based on the DMs judgment, and employing the VIKOR technique for comprehensive supplier ranking. The findings underscore the methodology's effectiveness in enhancing decision-making, offering a unified metric that accommodates diverse criteria and balances precise data with subjective assessments. This approach simplifies the evaluation process, particularly in situations with conflicting interests among decision-makers. Demonstrating its practical application in the crumb rubber industry, the study highlights the methodology's potential for broader industrial applicability. Future research could explore comparative analyses with other analytical methods, further establishing the methodology's robustness and adaptability in different management contexts.
Desenvolvimento de um Software de Aquisição de Dados Georreferenciados e Análise de Aplicabilidade em Área Urbana com Vegetação de Cerrado (Development of a Software Data Acquisition and Analysis of Georeferenced Applicability in Urban Area ...)
Authors: Barbosa Rogério Zanarde , Perea Martins João Eduardo Machado 
Published: December 2023

Este trabalho apresenta o desenvolvimento de um software de aquisição de dados georreferenciados, que realiza simultaneamente a aquisição de dados de um GPS e de um dispositivo de sensoriamento, via interface de comunicação serial, e então cria um único registro com os valores das medições físicas, da localização, a data e o horário. O diferencial do trabalho é que ele prova ser possível desenvolver um sistema simples, com fácil operação e baixo custo, que pode ser utilizado como uma eficiente alternativa para a melhoria das técnicas relativas ao georreferenciamento de medições ambientais. Neste trabalho, a eficiência do software foi analisada no monitoramento microclimático, medindo a temperatura e umidade relativa do ar de uma região urbana com vegetação típica de Cerrado, fornecendo informações que permitiram uma análise espacialmente distribuída dos parâmetros medidos na área. Os resultados do software foram satisfatórios e o mesmo apresentou grande potencial para uso em diferentes áreas como, geografia, agricultura, meio ambiente, planejamento urbano, etc. ABSTRACT This work presents the development of georeferenced data acquisition software that performs simultaneously the data acquisition from a GPS and a sensing device, via serial communication interface, and composes only one record with values ​​of physical measurements, location, date and time. This work differential is that it proves the viability to develop a simple system with easy operation and low cost, which can be used as an efficient alternative to improve the techniques related to the georeferencing of environmental measurements. In this work, the software efficiency was analyzed in the microclimatic monitoring, measuring temperature and relative humidity of the in an urban area with typical Cerrado vegetation, providing information that allowed an analysis of the spatially distributed parameters measured in the area. The results were satisfactory and the software has shown great potential for uses in different areas such as geography, agriculture, environment, urban planning, etc. Keywords: software, data acquisition, environmental monitoring, georeferencing.
Pontos Potenciais de Contaminação e Vulnerabilidade Natural das Águas Subterrâneas do Município de Restinga Seca - RS (Potential Sources of Contamination and Natural Vulnerability of the Groundwater in Restinga Seca Municipality, Rio Grande do Sul State)
Authors: Löbler Carlos Alberto , Ertel Tiago , Martelli Guilherme Viana , Silvério da Silva José Luiz 
Published: December 2023

O presente trabalho aborda as características naturais das águas subterrâneas do município de Restinga Seca, situado na borda da Bacia do Paraná, sul do Brasil, na Depressão Central constituída predominantemente por arenitos pertencentes à Zona de Afloramento (ZA) do Sistema Aquífero Guarani - SAG. O município possui 54 captações por poços cadastrados no Sistema de Informações de Águas Subterrâneas/SIAGAS, sendo 19 selecionados no estudo. Dentre as principais fontes potenciais de contaminação foram identificados 3 postos de combustíveis e 2 cemitérios. O estudo apontou um índice de vulnerabilidade dos Sistemas Aquíferos (Serra Geral e Guarani) para todo o município: 0,02% média; 48,98% baixa e predominando a insignificante com 51,00%. O Perímetro urbano apresentou cerca de 23,00% na classe média e 67,00% na insignificante. Observou-se que os pontos potenciais de contaminação estão localizados em áreas das classes de vulnerabilidade insignificante e baixa. A B S T R A C T This paper addresses the natural characteristics of groundwater in the municipality of Restinga Seca, situated on the edge of the Paraná Basin in the Central Depression, southern Brazil. It consists predominantly of sandstones belonging to Outcrop Zones (ZA) Guarani Aquifer System - GAS. The city has 54 registered wells funding 19 were selected to this study. Were identified the main potential contamination sources three gas stations and two cemeteries. The study reported a vulnerability index Aquifers Systems (Serra Geral and Guarani) for the entire county: 0.02% moderate, 48.98% low and predominantly negligible with 51.00%. The urban perimeter showed about 23.00% moderate and circa 67.00% in negligible class. It was observed that the points of potential contamination areas are located in classes of low and negligible vulnerability. Keywords: Aquifers, GAS, contamination, cartograms.
Condições Sinóticas em Episódio de Rajadas de Vento na Região Metropolitana de Salvador (Synoptic Conditions in a Wind Gust Episode in Metropolitan Salvador)
Authors: Silva Alexandra Barbosa , Aragão Maria Regina da Silva , Correia Magaly de Fatima 
Published: December 2023

O foco deste trabalho são as rajadas de vento registradas no Aeroporto Internacional de Salvador no período 2003-2011. Variáveis meteorológicas observadas à superfície na área do aeroporto, imagens de satélites meteorológicos e dados em pontos de grade foram utilizados para analisar a variabilidade interanual, sazonal e horária das rajadas, e diagnosticar as condições sinóticas de um caso selecionado. Um percentual de 51% do número total de rajadas de vento foi registrado em 2003 e 2007 (em conjunto), com valores muito próximos. O mês de maio teve o maior percentual de registros de rajadas (22%), e as direções do setor sul da rosa dos ventos foram as mais frequentes (51%). No caso selecionado (10-11 de maio de 2007) houve cinco registros, no período da noite, com a direção do vento variando entre 170 e 200 graus. A rajada mais forte, com 190 graus e 69 km/h, ocorreu às 01 UTC do dia 11. Nuvens de convecção profunda (cúmulos congestos) foram observadas na área do aeroporto. Esse caso foi associado à passagem de um sistema frontal em Salvador, evidenciada pela variação diária de elementos atmosféricos observados à superfície na estação meteorológica do aeroporto. Segundo a Coordenadoria de Defesa Civil de Salvador (CODESAL), as fortes variações do vento causaram desabamento e destelhamento de imóveis registrados no dia 11.

A B S T R A C T
This work focuses on wind gusts observed at the Salvador International Airport during the period 2003-2011. Surface meteorological variables observed at the airport, meteorological satellite images and gridpoint data were used to analyze the interannual, seasonal and hourly variability of the wind gusts and to diagnose the synoptic conditions of one selected case. A fifty two percent of the total number of wind gusts was found in 2003 and 2007 (altogether), with very close values. May had the highest percentage of wind gust reports (22%), while wind directions in the southern sector of the wind rose were more frequent (51%). The selected case (10-11 May 2007) had 5 gusts, at night, with wind direction varying from 190 to 200 degrees. The strongest wind gust, with 190 degrees and 69 km/h, occurred at 01 UTC on the 11th. Deep cumulus clouds (cumulus congestus) were observed within the airport area. This case was associated with a frontal passage in Salvador, as shown by the daily variability of the atmospheric elements observed at the airport surface meteorological station. The Civil Defense of Salvador (CODESAL) registered collapsed and unroofed houses on the 11th.

Keywords: surface wind, extreme event, frontal system, Bahia, Northeast Brazil
Mapeamento da Deterioração Ambiental em Área de Vegetação de Caatinga (Mapping of Environmental Deterioration in Vegetation Caatinga Area)
Authors: Francisco Paulo Roberto Megna , Ribeiro George do Nascimento , Moraes Neto João Miguel de 
Published: December 2023

O desmatamento, a baixa fertilidade, a erosão, a salinização, e a compactação do solo são fatores de degradação ambiental, e com intervenções inadequadas das atividades humanas sobre o meio ambiente, como a supressão da cobertura vegetal para a introdução de práticas agrícolas e pecuárias, a exploração de bens minerais e implantação de núcleos urbanos, os processos erosivos se intensificam e passam a comprometer os principais recursos naturais do planeta, em particular, o solo e a água superficial. Este trabalho objetivou o mapeamento da deterioração ambiental do município de Sumé utilizando o Índice de Deterioração das Terras Semiáridas para a realização de diagnósticos através de técnicas de geoprocessamento. No mapeamento foi estimada a erodibilidade dos solos, a cobertura vegetal e a declividade utilizando a linguagem algébrica do SPRING para o cruzamento das informações. Observou-se que 82,77% das terras apresentaram relevo plano e suave ondulado; os solos apresentaram erodibilidade alta em 73,3% da área; as classes baixa e muito baixa de cobertura do solo ocupam 48,6%. Os resultados demonstram que 39,59% das terras apresentam níveis médios de deterioração. A B S T R A C T The inappropriate use and management of lands have degraded soils, accelerating the impact of human activities on the environment, particularly in semi-arid regions and integrated knowledge of the landscape and acting processes is important to interpret the environment in a perspective that admits interrelationships the various attributes of the land. This study aimed at mapping the environmental deterioration of the municipality of Sumé-PB using the Index Deterioration of semiarid lands to perform diagnoses using GIS techniques. In the mapping we estimated the erodibility of soils, land cover and slope using the algebraic language for the SPRING crossing information. It was observed that the lands of the study area is predominantly flat to mild wavy, with slopes less than 6%. The class is represented by High erodibility Entisols and chromic Luvisols. The very high and high class due to lower soil protection by vegetation totaling 6.34% of the area. The results demonstrate that the high and very high levels of deterioration of land are associated with high erodibility of chromic Luvisols vertics and the low level of protection of ground vegetation of the area. Keywords: Degradation, Modeling, Geoprocessing.
Variabilidade Espacial e Temporal das Precipitações para a Microrregião de Pau dos Ferros-RN (Spatial and Temporal Variability of Precipitation for the Microregion of Pau dos Ferros-RN)
Authors: Santos Wesley de Oliveira , Silva Ketson Bruno da , Coelho Daniela da Costa Leite , Silva Karen Mariany Pereira , Sobrinho José Espínola , Silva Paulo Cesar Moura da , Batista Rafael Oliveira 
Published: December 2023

A precipitação pluviométrica apresenta importância para os estudos climáticos, pois quando ocorrida em excesso, ocasiona implicações para os setores produtivos da sociedade tanto econômico e social, causando enchentes, assoreamento dos rios, e quedas de barreiras. O presente trabalho teve o objetivo de realizar uma análise da variabilidade espacial e temporal da precipitação pluvial média e da máxima média anual, para a microrregião de Pau dos Ferros-RN, por meio de uma geotecnologia, especificamente modelagem espacial. Para realização do processamento dos dados e confecção das cartas foi utilizado o SIG (Sistema de Informação Geográfica), onde os postos meteorológicos dos dezessete municípios foram georreferenciados para projeção cartográfica UTM, DATUM WGS 84, fuso (zona) 24. O método de interpolação utilizado foi o inverso do quadrado da distância (IQD). Para verificar a acurácia da interpolação, foi calculado o erro médio quadrático (RMSE - Root Mean Square Error). O erro médio quadrático (RMSE) apresentou um valor de 0,06544 mm para a precipitação média anual, já para a precipitação média máxima anual foi 0,00764 mm. O interpolador do inverso do quadrado da distância mostrou-se bastante eficaz para especializar a precipitação pluviométrica. O conhecimento da variabilidade espacial das precipitações anuais e máximas ao longo da serie histórica em estudo permitem auxiliar no manejo das práticas agrícolas e no planejamento de obras de engenharia hidráulica. ABSTRACT Rainfall has importance for climate studies, because when it occurs in excess, leads to implications for the productive sectors of society both economic and social, causing flooding, siltation of rivers and landslides. This study aimed to perform an analysis of the variability spatial and temporal of rainfall and average maximum annual average for the micro region of Pau do Ferros-RN, through a geotechnology, specifically spatial modeling. To perform the data processing and manufacturing of the cards was used GIS (Geographic Information System), where the weather stations of the seventeen counties were georeferenced cartographic projection UTM, WGS 84 DATUM, zone (zone) 24. The interpolation method used was the inverse square of the distance (QID). To verify the accuracy of the interpolation, we calculated the root mean square error (RMSE). The root mean square error (RMSE) had a value of 10.6 mm for daily rainfall average annual, as for the daily rainfall average maximum annual was 12.8 mm. The knowledge of the spatial variability of annual rainfall and maximum along the historical series study to assisting in the management of agricultural practices and planning of hydraulic engineering. Keywords: precipitation, distribution, spatial modeling.
Impactos Ambientais na Margem Direita do rio Jauru no Bairro Beira Rio, Porto Esperidião – Mato Grosso (Environmental Impacts on the Right Bank of the Jauru River in the Beira Rio neighborhood, Porto Esperidião - Mato Grosso)
Authors: Pires Eliane , Andrade Leila Nalis Paiva da Silva , Soares José Carlos de Oliveira , Leandro Gustavo Roberto dos Santos 
Published: December 2023

A presente pesquisa trata sobre as questões de uso e ocupação da margem direita do rio Jauru, no bairro Beira Rio na cidade de Porto Esperidião - Mato Grosso. Os procedimentos metodológicos utilizados foram: o trabalho de campo para caracterização da área, identificação dos tipos de uso com registros escritos e fotográficos e a pesquisa quali-quantitativa com questionário semi-estruturado. Neste contexto, foi identificado o uso e ocupação desordenado e inadequado, o que, contribui com o aumento dos impactos ambientais no rio, tais como, retirada da vegetação, assoreamento, poluição das águas e erosão marginal. Cabe salientar que, o uso intenso e processo de ocupação, ocorrem em Área de Preservação Permanente (APP), sendo área de uso restrito. A B S T R A C T This research is about the issues of use and occupy of the right bank of Jauru River at Beira Rio neighborhood in Porto Esperidião - Mato Grosso. The methodological procedures used were: field work to characterize the area, identifying patterns of use with written and photographic records and qualitative and quantitative research with semi-structured questionnaire. In this context, it was identified cluttered and inadequate of the use and occupation, which contributes to increase environmental impacts on the river, such as removal of vegetation, siltation, pollution of waters and marginal erosion was identified. It is worth mentioning that the intensive processes and occupations occur in Permanent Preservation Area (APP), with a restricted use. Keywords: water resources, urban area, Environmental Education.
Current regulatory requirements for clinical trials of viral vaccines
Authors: Soldatov A. A. , Gorenkov D. V. , Avdeeva Zh. I. , Merkulov V. A. 
Published: December 2023

Scientific relevance. In recent years, the development of various vaccines based on novel platforms has underscored the significance of updating regulatory requirements for vaccines. Consequently, clinical trials of viral vaccines need harmonised approaches within national guidelines and the Eurasian Economic Union (EAEU) regulatory framework.Aim. This study aimed to analyse national and international requirements for clinical trials of the efficacy and safety of preventive viral vaccines.Discussion. This article presents an analysis of the guidelines issued by the WHO and leading regulatory authorities on different aspects of clinical trials of viral vaccines. These guidelines place particular emphasis on the immunogenicity of vaccines. The lack of well-established immune correlates of protection for most infections presents a significant problem for assessing the effectiveness of vaccines. Immunobridging studies may be conducted to expand vaccine indications to different populations (such as a new age group). The size of the prelicensure safety database should include data on at least 3,000 vaccinated study participants. For some vaccines, safety studies must assess the risk of disease onset or enhancement due to vaccination.Conclusions. The clinical trial requirements for viral vaccines have been substantially aligned by the WHO and major international regulatory authorities, thereby facilitating the development of harmonised national or EAEU guidelines.
Efficacy of interferon inducers against Chikungunya virus <i>in vitro</i>
Authors: Otrashevskaja E. V. , Kaa K. V. , Samartseva T. G. , Oksanich A. S. , Ignatyev G. M. 
Published: December 2023

Scientific relevance. To date, no specific antivirals have been approved to treat and prevent Chikungunya fever, its complications, and sequelae. Therefore, the development of therapeutic and preventive medicinal products against Chikungunya virus (CHIKV), including interferon inducers, is gaining relevance.Aim. The authors aimed to study the effectiveness of prophylactic administration of an interferon inducer against CHIKV in an in vitro model.Materials and methods. The study used two cell lines (Vero and А549), a CHIKV strain (Nika2021), and an interferon-inducing medicinal product (double-stranded RNA sodium salt) at two doses (250 μg/mL and 500 μg/mL) administered at two schedules: Prevention (4 h prior to the virus challenge) and Emergency Prevention (at the time of the virus challenge). The authors determined the CHIKV titre by its cytopathogenic effect, the CHIKV RNA content by the cycle threshold value in real-time reverse-transcription polymerase chain reaction, and the concentration of cytokines using the enzyme immunoassay method. The study monitored the changes in CHIKV biological activity, CHIKV RNA levels, and the production of interferon-alpha (IFN-α), interferon-gamma (IFN-γ), interleukin-6 (IL-6), and tumour necrosis factor-alpha (TNF-α) in cells over time. The statistical analysis of the resulting data used Microsoft Office Excel 2016 and StatTech.Results. The medicinal product at doses of 250 μg/mL and 500 μg/mL stimulated the production of both IFN-α and IFN-γ (IFN-α to a greater extent than IFN-γ) in both cell lines (in A549 to a greater extent than in Vero). The changes in CHIKV RNA levels with time corresponded to those of the virus titre. In general, CHIKV RNA levels in Vero cells were significantly higher than those in A549 cells (р<0.002 at 250 μg/mL and р<0.0005 at 500 μg/mL). The CHIKV RNA content after preventive interferon inducer administration was significantly lower than that in the control experiment (challenge without administration of the medicinal product) for both doses and both cell lines (р<0.002 for Vero cells; р<0.0003 for А549 cells). The CHIKV RNA content after interferon inducer administration as emergency prevention was significantly lower than that in the control experiment (р<0.05 for Vero cells; р<0.003 for А549 cells). The study demonstrated the efficacy of the interferon inducer against CHIKV and a higher applicability of the A549 cell line to studying antiviral activity in vitro. The authors observed the production of IL-6 and TNF-α by intact cells of both lines.Conclusions. According to the results, the studied interferon inducer has a positive antiviral effect against CHIKV in vitro, with the antiviral effect degree depending on the cell line used. This experimental study demonstrated the need to carefully select the cell line for a study in accordance with its objectives and to evaluate the production of cytokines by a monolayer of cells before stimulation with viruses and/or medicinal products.