bluuebunny/crossref_metadata_2025_split huggingface dataset:
Potential Effects of an Exoskeleton-Assisted Overground Walking Program for Individuals With Spinal Cord Injury Who Uses a Wheelchair on Imaging and Serum Markers of Bone Strength: Pre-Post Study
Authors: Bass Alec , Morin Suzanne N , Guidea Michael , Lam Jacqueline T A T , Karelis Antony D , Aubertin-Leheudre Mylène , Gagnon Dany H ,   Montreal Exoskeleton Walking Program (MEWP) Group
Published: November 2023

Background
As many as 60% of individuals use a wheelchair long term after a spinal cord injury (SCI). This mode of locomotion leads to chronic decline in lower-extremity weight-bearing activities and contributes to the development of severe sublesional osteoporosis and high rates of fragility fracture. Overground exoskeleton-assisted walking programs provide a novel opportunity to increase lower-extremity weight bearing, with the potential to improve bone health.

Objective
The aim of the study is to measure the potential effects of an exoskeleton-assisted walking program on lower-extremity bone strength and bone remodeling biomarkers in individuals with chronic (≥18 months) SCI who use a wheelchair.

Methods
In total, 10 participants completed a 16-week exoskeleton-assisted walking program (34 individualized 1-hour sessions, progressing from 1 to 3 per week). Bone mineral density and bone strength markers (dual-energy x-ray absorptiometry: total body, left arm, leg, total hip, and femoral neck and peripheral quantitative computed tomography: 25% of left femur and 66% of left tibia) as well as bone remodeling biomarkers (formation=osteocalcin and resorption=C-telopeptide) were measured before and after intervention and compared using nonparametric tests. Changes were considered significant and meaningful if the following criteria were met: P<0.1, effect size ≥0.5, and relative variation >5%.

Results
Significant and meaningful increases were observed at the femur (femoral neck bone mineral content, bone strength index, and stress-strain index) and tibia (cortical cross-sectional area and polar moment of inertia) after the intervention (all P<.10). We also noted a decrease in estimated femoral cortical thickness. However, no changes in bone remodeling biomarkers were found.

Conclusions
These initial results suggest promising improvements in bone strength markers after a 16-week exoskeleton-assisted walking program in individuals with chronic SCI. Additional research with larger sample sizes, longer interventions (possibly of greater loading intensity), and combined modalities (eg, pharmacotherapy or functional electrical stimulation) are warranted to strengthen current evidence.

Trial Registration
ClinicalTrials.gov NCT03989752; https://clinicaltrials.gov/ct2/show/NCT03989752

International Registered Report Identifier (IRRID)
RR2-10.2196/19251
Circulating Activin A, Kidney Fibrosis, and Adverse Events
Authors: Tsai Ming-Tsun , Ou Shuo-Ming , Lee Kuo-Hua , Lin Chih-Ching , Li Szu-yuan 
Published: November 2023

Background
Identification of reliable biomarkers to assess kidney fibrosis severity is necessary for patients with CKD. Activin A, a member of the TGF-β superfamily, has been suggested as a biomarker for kidney fibrosis. However, its precise utility in this regard remains to be established.

Methods
We investigated the correlation between plasma activin A levels, kidney fibrosis severity, and the incidence of major adverse kidney events in patients who underwent native kidney biopsies at a tertiary medical center. We performed RNA sequencing and histological analyses on kidney biopsy specimens to assess activin A expression. In vitro experiments were also conducted to explore the potential attenuation of TGF-β–induced fibroblast activation through activin A inhibition.

Results
A total of 339 patients with biopsy-confirmed kidney diseases were enrolled. Baseline eGFR was 36 ml/min per 1.73 m2, and the urine protein/creatinine ratio was 2.9 mg/mg. Multivariable logistic regression analysis revealed a significant association between plasma activin A levels and the extent of tubulointerstitial fibrosis. Our RNA sequencing data demonstrated a positive correlation between kidney INHBA expression and plasma activin A levels. Furthermore, the histological analysis showed that myofibroblasts were the primary activin A–positive interstitial cells in diseased kidneys. During a median follow-up of 22 months, 113 participants experienced major adverse kidney events. Cox proportional hazards analysis initially found a positive association between plasma activin A levels and kidney event risk, but it became insignificant after adjusting for confounders. In cultured fibroblasts, knockdown of activin A significantly attenuated TGF-β–induced fibroblast–myofibroblast conversion.

Conclusions
Plasma activin A levels correlate with kidney fibrosis severity and adverse outcomes in various kidney disorders.
Tools for Implementing Strategies in the Context of Digital Transformation of Industrial Enterprises
Authors: Shabaeva S. V. , Shabaev A. I. 
Published: November 2023

Under conditions of uncertainty caused by sanctions and geopolitical changes, the correct choice of both strategic development priorities and management tools for their implementation becomes important. Given the global trend towards digitalization and the growing supply from software developers, it is necessary to understand clearly, which software products and for what purposes can be used effectively at specific enterprises. The challenge here is that due to instability, sanctions pressure, and withdrawals of foreign software from the Russian market, enterprises are forced to change business and technological processes, and to look for new tools for implementing development strategies. The purpose of the article is to determine the basic principles for choosing strategic management tools and information technologies as elements of strategic management at enterprises in the context of digital transformation. The article shows that due to the ongoing digitalization of industrial enterprises any tools for implementing the strategies must be considered within the framework of an automated process management model. It can be based on various information technologies or platform solutions, depending on the coverage of enterprise business processes, and the readiness to adopt digital technologies in strategic and operational management. The modern trend is to implement strategic development directions, relying on the internal ecosystem of the enterprise. Making the right choice of information technology within an enterprise ecosystem requires that technology investments are aligned with the company’s business goals, adaptable to changing needs, can integrate with existing systems, are user-friendly, secure, and provide a short-term return on investment. Ultimately, these principles enable businesses to successfully navigate the digital transformation journey and leverage technology as a strategic enabler for sustainable growth.
The nature of lesions of the central nervous system in infections, caused by <i>Varicella Zoster</i> virus
Authors: Eshmolov S. N. , Klimovitskaya E. G. , Kuzmina M. N. , Sitnikov I. G. 
Published: November 2023

Varicella Zoster virus can cause damage to the nervous system, more often in the form of meningitis and meningoencephalitis.Purpose: to identify the nature of damage to the central nervous system during infections caused by the Varicella Zoster virus. Materials and methods. The article presents the literature data and the results of own observations of 47 patients treated at the Infectious Diseases Clinical Hospital of Yaroslavl in the period from 2015 to 2021. There were 20 children (42.6%) aged from 18 days to 12 years with chickenpox. There were 27 (57.4%) patients with Herpes Zoster, of which 20 (74.1%) were adults aged 24 to 82 years, 7 (25.9%) were children aged 4 to 14 years. Results. The main clinical and laboratory indicators were analyzed, the features of central nervous system lesions caused by the Varicella Zoster virus were revealed, and the medical and social significance of this problem was confirmed. Among the patients, patients with Herpes Zoster predominated — 27 (57.4%). Meningitis (45.0%), meningoencephalitis (30.0%) and encephalitis (25.0%) were recorded in children with chickenpox. In children with Herpes Zoster, meningoencephalitis predominated (71.4%), while in adults - meningitis (65.0%); there were no encephalitis. There were no deaths, 14.9% of patients were transferred to the neurological department, 85.1% were discharged as outpatients.
Experience of using inhaled steroid therapy in children with whooping cough
Authors: Popova O. P. , Shvetsova Yu. V. , Bunin S. V. , Fedorova I. M. , Koteleva S. I. , Grechishnikova O. G. 
Published: November 2023

The aim of study: аnalysis of the effectiveness of inhaled steroid therapy in patients with whooping cough.Materials and methods: 74 patients with whooping cough were observed, among whom 40 children included inhalations with Budesonide in complex therapy (main group). 34 patients in the comparison group received only basic therapy. The age structure in the main group was as follow: тhere were children under one years old 18 (47.4 ± 8.1%), 1—3 years — 7 (18.4 ± 6.3%); 4—6 years — 8 (21 ± 6.6%), 7—14 years — 7 (13.2 ± 5.5%) and comparable to the comparison group. To verify whooping cough were used the PCR method and serological diagnostic (IFA) using a test system “Ridascreen/Bordetella pertussis («R-biofarm AMG», Germany). Results: budеsonide was prescribed for a course of 5—7 days. Clinical analysis of dynamics of cough in main group showed, that a reduction in a number of attacks by the 4—5th day of budesonide was observed in majority of children (35/87.5 ± 5.2%). In the main group coughing attacks with a frequency of more than 15—25 times a day persisted for 2.7 ± 0.2 days, and in comparison group — 4.3 ± 0.2 (p < 0.001). Relief of broncho-obstructive syndrome was observed in shorter period of time, which contributes to a reduction in the average length of stay of the patient in the hospital.
Trends in income taxation: are taxes converging in Central and Eastern European countries?
Authors: Bernardelli Michał , Felis Paweł , Jamroży Marcin , Lipiec Jacek , Malinowska-Misiąg Elżbieta , Szlęzak-Matusewicz Joanna , Otczyk Grzegorz 
Published: November 2023

Abstract
The paper examines the convergence of tax systems in Central and Eastern European countries (CEECs) over the period 1995–2018. Due to the increasing impact of tax competition, we have focused on income taxes, in particular, corporate ones. We have identified the factors that influence the taxation system and trends in income taxation in the CEECs by adapting the hidden Markov model approach. We find that many CEECs have reduced income taxation in the analysis period, mainly by lowering tax rates. Corporate income taxes have also decreased in many CEECs in the same period; however, the reverse has been observed too. Both convergence and divergence have been identified among the CEECs over the period considered. The speed of these processes based on the used variables varied depending on both exogenous and endogenous factors. These factors have been diagnosed as being specific to the periods of tax reforms, i.e., before and after accession to the European Union (EU) and the global financial crisis.
Crafting Intellectual Community Online
Authors: Cronsberry Bronte 
Published: November 2023

By engaging in a close reading of the work of @snappydragon and @sexycyborg, “Crafting Intellectual Community Online” explores how they assert a personal identity that is strongly tied to their embodied experiences as women, each with distinct interests and positionalities: one a Jewish woman interested in historical clothing and identifying dress, and the other a Chinese woman interested in cyberpunk and augmentation. In addition to the thematic links in their work, both assert their personal agency by explaining their making process in ways that showcase the conceptual considerations of the project through to the material execution, inviting viewers to engage in similar considerations by taking up a making practice of their own. By placing their work in dialogue, “Crafting Intellectual Community Online” argues for an intellectual community that develops outside the academy and enables collaborative thought across physical and temporal distance. My work thinks through these invitations in relation to the theoretical work of Hannah Arendt and Paulo Friere, drawing on ideas related to the formation of an intellectual community of peers through a dialogic method which can then be reinterpreted in relation to the unique challenges of the internet as a new site of education beyond the academy.
RAPD Primers Selection for Genetic Variation Analysis of Banana Plant (Musa spp.)
Authors: Wiguna I Ketut Catur , Pharmawati Made 
Published: November 2023

Identification of genetic diversity using molecular markers is important for basic information for plant conservation. Banana is a fruit bearing plants that important for food sources in human life. This study aimed to determine the optimum conditions of PCR-RAPD reaction and RAPD primers that suitable to amplify DNA fragmens. DNA isolation was done using modified of CTAB and chloroform isoamil alcohol. The samples used was young leaves of nine banana cultivar plants. Optimation was done using variety of DNA and MgCl2 concentration. Eight primers produced by Operon Primer Technology were tested. The DNA genomic concentration obtained was in the range of 23,3 ng/µl – 70 ng/µl. The optimum conditions of PCR-RAPD of banana plants that produce clear band were 50 ng/µl DNA template, 3 mM MgCl2 with the number of thermal cycles was 40 x. There were six RAPD primers that successfully amplified DNA : OPA 02, OPA 04, OPB 12, OPD 20, OPH 01, and OPH 03. The primer OPA-04 had the lowest resolving power value (4,4) , while OPH 01 had the highest (11,3) resolving power.
Pengembangan Wilayah Agropolitan Untuk Menyelaraskan Kota dan Desa
Authors: Miranti Alia , Yuliani Eppy 
Published: November 2023

Pengembangan wilayah Kawasan agropolitan merupakan titik tumbuh ekonomi daerah dengan basis pertanian. Perkembangan wilayah dengan agropolitan ini dilakukan desa dan kota yang memiliki potensi di bidang pertanian, tetapi potensi ini tidak menjadikan hal untuk berkembang yang sama antara desa dan kota. Perkembangan menyababkan kesenjangan anatar desa dan kota. Oleh karena itu penelitian ini bertujuan untuk mengetahui cara untuk menyelaraskan pertumbuhan perkotaan dan pedesaan melalui agropolitan. Metode mengidentifikasi potensi, ketersediaan kriteria pusat pertumbuhan dengan pendekatan deskriptif. Analisis menggunakan variabel temuan dari tiga studi kasus dengan mengkomparasikan hasil temuan dari masing-masing studi kasus. Hasil dari komparasi diketahui bahwa untuk menyelaraskan pengembangan desa dan kota dengan agropolitan dipengaruhi kebijkan fungsi lahan Â jenis komoditas, dan infrastruktur pertanian yang mendukung menjadi pusat kegiatan agribisnis.Kata Kunci : Agropolitan, Perkembangan, Desa, Kota
KECERDASAN KEUANGAN PENGUSAHA MUSLIM BUGIS DALAM PRAKTIK PENGELOLAAN USAHA PEDULI MASLAHAH
Authors: Anizah Nur , Marzuki Sitti Nikmah 
Published: November 2023

Penelitian ini bertujuan untuk mengetahui tingkat kecerdasan keuangan pengusaha Muslim Bugis pada UMKM binaan Dinas Perindustrian Kabupaten Bone. Penelitian ini menggunakan pendekatan kualitatif dari aspek metodologinya dan pendekatan keilmuan dibidang ilmu ekonomi islam. Dalam mengumpulkan data digunakan metode wawancara, data yang digunakan yaitu sembilan pengusaha Muslim Bugis pada UMKM binaan Dinas Perindustrian yaitu masing-masing tiga dari Kecamatan Tanete Riattang, Tanete Riattang Barat dan Tanete Riattang Timur. Hasil penelitian menunjukkan bahwa pengusaha Muslim Bugis pada UMKM binaan Dinas Perindustrian Kabupaten Bone memiliki tingkat kecerdasan keuangan pada tingkat middle class (kelas menengah). Hal ini dilihat dari cashflow pengusaha Muslim Bugis, dari pendapatannya disisihkan untuk pembelian investasi berupa aset, sisanya dikeluarkan untuk beban usaha, dan biaya konsumsi lainnya. Sedangkan dalam praktik pengelolaan usaha peduli maslahah, dilihat dari aspek manfaat fisiknya, pengusaha Muslim Bugis lebih mengedapankan fungsi produk dari pada profit, dan menjamin kualitas produk. Sedangkan dari aspek non-fisik, pengusaha Muslim Bugis sangat memperhatikan kehalalan produknya, pendapatannya juga disisihkan untuk ZISWAF dan kegiatan sosial lainnya, selain itu dapat memberikan lapangan pekerjaan kepada orang lain, sehingga pengusaha Muslim Bugis dalam praktik pengelolaan usahanya sesuai dengan maslahah, yang dapat memelihara agama, diri, akal, keturunan dan harta.
KONTRIBUSI USAHA GETAH PINUS DALAM MENINGKATKAN PEREKONOMIAN MASYARAKAT MUSLIM (Studi Pada Desa Rappa Kec. Tonra Kab. Bone)
Authors: Inna Nur Fatma , Jumarni Jumarni 
Published: November 2023

Penelitian Jurnal iniberjudul “Kontribusi Usaha Getah Pinus Dalam Meningkatkan Perekonomian Masyarakat Muslim (Studi Pada Desa Rappa Kec. Tonra Kab. Bone). Kajian dalam penelitian ini adalah seberapa besar kontribusi usaha getah pinus dalam meningkatkan perekonomian Masyarakat Muslim di Desa Rappa. Penelitian ini bertujuan untuk mengetahui adalah seberapa besar kontribusi usaha getah pinus dalam meningkatkan perekonomian Masyarakat Muslim di Desa Rappa. Penelitian ini merupakan penelitian lapangan. Pendekatan dalam penelitian ini adalah pendekatan kualitatif. Jenis data dalam penelitian ini adalah Data Primer yakni data yang diperoleh secara langsung dari subjek yang diteliti yakni pekerja usaha getah pinus. Data Sekunder yakni data yang berfungsi sebagai pelengkap data primer. Metode pengumpulan data dalam penelitian ini adalah observasi, wawancara dan dokumentasi. Tekhnik analisis data digunakan untuk menganalisis data, penulis menggunakan metode analisis deskriptif, yaitu gambaran secara sistematis, factual dan akurat mengenai fenomena pelaksanaan pengelolaan usaha getah pinus oleh masyarakat muslim di Desa Rappa Kec. Tonra Kab. Bone. (2) faktor pendorong dan penghambat dalam mengelola usaha getah pinus yaitu: modal, musim, tempak pengeloaan, jarak lokasi, tingkat kebutuhan masyarakat, umur sedapan, keulekan kerja dan manajemen waktu. Implikasinya bagi penulis yaitu menambah wawasan penulis dalam hal kontribusi usaha getah pinus dalam pemenuhan kebutuhan masyarakat. Dan setiap kepala keluarga memiliki kewajiban untuk memenuhui kebutuhan keluarganya dan harus sesuai dengan ajaran islam yaitu untuk kesejahtaraan atau kemaslahatan masyarakat.Menambah wawasan penulis terkai faktor- faktor yang mendorong sekaligus dapat juga menjadi penghambat dalam pengelolaan usaha getah pinus.
Developing Student's Speaking Competence Through Storytelling at the Second Grade Student's of SMK Negeri 1 Magelang in Academic Year 2013 / 2014
Authors: Septanti Rina Dewi , Ghozali Imam , Robiasih Hasti 
Published: November 2023

This research is aimed to describe the development of a model of teaching speaking competence called Storytelling, a model of teaching English to enhance the students’ speaking competence. Further, the research also reveals the strengths and limitations of aims at Storytelling activity in SMK Negeri 1 Magelang. This research belongs to an educational research and development (or called R & D). The model was developed adapting Borg and Gall’s Model (1983) simplified into six steps. The steps are (1) Theories and Studies related to Storytelling Technique or Product Analysis, (2) Planning and Preparation for doing Storytelling Technique, (3) Expert Validation and Revision Related to Storytelling Technique , (4) Developing Storytelling Technique in class, (5) Revision of Product , and (6) Final Product . The field tryout was conducted in one class of grade XI students of SMK Negeri 1 Magelang . The instruments used in this research were classroom observation sheet, students’ opened-questionnaire sheet and questions of students’ interview. The collecting data in this research were analyzed by using qualitative and analysis from Miles and Huberman (1994) consisting of four steps of collecting data, reducing data, displaying data, and verifying conclusions. Findings show that Storytelling as a model of teaching speaking shows some strengths; in development stage students’ speaking competence, students’ willingness to voluntary tell their experience in front of the class, the class’ participation in asking questions to the presenters, their willingness to attend the storytelling activity patiently, and also their disappointment due to not being given a chance to perform in front of the class get improvement. Furthermore, Storytelling is a meaningful activity which gives some benefits to the students such as developing feeling of self confidence and braveness and providing more chance to speak that can develop students’ speaking competence.
Hearing a Circle: An Exploratory Study of Accessible Sonification for Young Children with Blindness and Low Vision
Authors: DAMSMA PHIA 
Published: November 2023

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<p>This paper describes a qualitative study of educational outcomes for 0–8-year-old children with blindness and low vision (BLV) who are learning sonification concepts. Children with BLV experience barriers to accessing education and careers in Science, Technology, Engineering and Mathematics (STEM), fields which traditionally rely heavily on visual representation of information. There is growing awareness of the potential of sonification, a technology to represent data and information in non-speech audio, to improve education access. While early learning of assistive technology skills is deemed essential for equity of access to education across the curriculum, children are generally not introduced to the concept of sonification at school until at academic level in secondary or tertiary education. Little is known about how young children with BLV engage with this promising technology. Phase 1 of the project consisted of the development of ‘CosmoBally on Sonoplanet’, an accessible, educational game application for iPads and Android tablets. In phase 2, an online qualitative survey collected formal responses from users of this app to Likert scale and open-ended questions. The majority of the 17 respondents were (specialist) educators, and five of the respondents identified as having BLV. The survey investigated respondents’ perceptions of the capabilities of young children with BLV in using basic sonification in ‘CosmoBally on Sonoplanet’ to identify shapes - including a circle-, orientate in a digital grid and create drawings on a touch screen. Results suggest that young children with BLV can learn sonification skills and that they additionally build relevant non-sonification skills during this learning process. This paper aims to provide a first insight into best practice around early learning of sonification as a potential tool for increased access and inclusion of children with BLV to STEM subjects in school. </p>