bluuebunny/crossref_metadata_2025_split huggingface dataset:
Oral immunotherapy as a curative treatment for food‐allergic preschool children: Current evidence and potential underlying mechanisms
Authors: Barten Lieke J. C. , Zuurveld Marit , Faber Joyce , Garssen Johan , Klok Ted 
Published: November 2023

AbstractThe worldwide rising prevalence of food allergy is a major public health concern. Standard care consists of allergen avoidance and rescue medication upon accidental exposure. Oral immunotherapy (OIT) is increasingly being studied as a treatment option. Although desensitization (an increased reaction threshold) is often achieved during OIT, sustained unresponsiveness (SU; clinical nonreactivity after finishing OIT) is not achieved in most patients. A few studies have investigated the effectiveness of OIT in children younger than 4 years of age (early = e‐OIT) and have shown a much more favorable outcome in terms of SU development. Together with food allergy prevention studies, which have demonstrated high efficacy of early oral allergen exposure, the outcomes of e‐OIT studies indicate an early‐life window of opportunity to achieve SU, allowing unrestricted dietary intake. However, the underlying mechanism of the high effectiveness of e‐OIT is not understood yet. Both cohort and OIT studies indicate early‐life immune plasticity. An immature food‐allergic response in the first years of life seems to be a major driver of this immune plasticity, along with a higher tolerogenic immunological state. Allergy maturation can likely be disrupted effectively by early intervention, preventing the development of persistent food allergy. Upcoming studies will provide important additional data on the safety, feasibility, and effectiveness of e‐OIT. Combined with immune mechanistic studies, this should inform the implementation of e‐OIT.
Identification of ascorbate‐ and salicylate‐responsive miRNAs and verification of the spectral control of miR395 in Arabidopsis
Authors: Székely András , Gulyás Zsolt , Balogh Eszter , Payet Rocky , Dalmay Tamás , Kocsy Gábor , Kalapos Balázs 
Published: November 2023

AbstractWe assumed that miRNAs might regulate the physiological and biochemical processes in plants through their effects on the redox system and phytohormones. To check this hypothesis, the transcriptome profile of wild‐type Arabidopsis and lines with decreased ascorbate (Asc), glutathione (GSH), or salicylate (Sal) levels were compared. GSH deficiency did not influence the miRNA expression, whereas lower levels of Asc and Sal reduced the accumulation of 9 and 44 miRNAs, respectively, but only four miRNAs were upregulated. Bioinformatics analysis revealed that their over‐represented target genes are associated with the synthesis of nitrogen‐containing and aromatic compounds, nucleic acids, and sulphate assimilation. Among them, the sulphate reduction‐related miR395 – ATP‐sulfurylase couple was selected to check the assumed modulating role of the light spectrum. A greater induction of the Asc‐ and Sal‐responsive miR395 was observed under sulphur starvation in far‐red light compared to white and blue light in wild‐type and GSH‐deficient Arabidopsis lines. Sal deficiency inhibited the induction of miR395 by sulphur starvation in blue light, whereas Asc deficiency greatly reduced it independently of the spectrum. Interestingly, sulphur starvation decreased only the level of ATP sulfurylase 4 among the miR395 target genes in far‐red light. The expression level of ATP sulfurylase 3 was higher in far‐red light than in blue light in wild‐type and Asc‐deficient lines. The results indicate the coordinated control of miRNAs by the redox and hormonal system since 11 miRNAs were affected by both Asc and Sal deficiency. This process can be modulated by light spectrum, as shown for miR395.
Frequency of red blood cell transfusions in preterm neonates in Brazil: A systematic review and meta‐analysis
Authors: Valete Cristina Ortiz Sobrinho , Angelica Luiz Ferreira Esther , Montenegro Carolina Perez , Pilati Maria Clara Alves , Rodrigues Wilde Marco Otílio Duarte , Witkowski Sandra Mara 
Published: November 2023

AbstractBackground and ObjectivesRed blood cell transfusions are frequent in preterm neonates. The proportion of preterm neonates transfused in Brazil remains unknown. We systematically reviewed the literature to estimate the frequency of red blood cell transfusions in preterm neonates in Brazil.Materials and MethodsThe LILACS, EMBASE, Cochrane, SciELO, MEDLINE (PubMed), Web of Science, Scopus, BDTD and 27 national university institutional databases were searched for studies that analysed red blood cell transfusion in preterm neonates in Brazil without period restriction. The Preferred Reporting Items in Systematic Reviews and Meta‐Analyses guidelines were followed, and the GRADE methodology was applied. A random‐effects model along with the restricted maximum likelihood method was used, and the Freeman–Tukey transformed proportion was used to estimate effect size.ResultsNine studies, representing 6548 preterm neonates, were included in the qualitative and quantitative analyses. The mean gestational age ranged from 26.0 to 31.6 weeks. Most of the studies were from the Southeast region. The pooled estimated frequency of red blood cell transfusions was 58.0% (95% confidence interval = 52.0%–64.0%, p < 0.001) with low certainty. There was statistically significant heterogeneity among studies (I2 = 92.5%, p < 0.001).ConclusionIn this current meta‐analysis of the evidence available, which included moderate and extremely preterm neonates, the observed frequency of red blood cell transfusions in preterm neonates in Brazil was 58.0% and this estimate can help health programming. Some Brazilian regions were not included in this study, and further research is needed to provide a more representative overview of Brazil.
Germination ecology and seedling growth of invasive Ageratum species and allied native Adenostemma lavenia
Authors: Airi Hemanti , Dangol Anuj , Shrestha Ashmita , Kharel Nisha , Devkota Anjana , Thapa Lal Bahadur , Shrestha Bharat Babu 
Published: November 2023

AbstractThe success of invasive plants can be better understood by comparing their traits with closely related native species. This study compared germination ecology and seedling growth of invasive Ageratum houstonianum and Ageratum conyzoides with co‐occurring and allied native Adenostemma lavenia. Seeds were germinated under a different light (12 h photoperiod/complete dark), temperatures (low: 25°C/15°C day/night, and high: 30°C/20°C), and different levels of water stress (−0.1, −0.25, −0.5, −0.75, and −1 MPa). Seedlings were grown to determine biomass allocation, relative growth rate (RGR), plant height, and number of leaves. The seed mass and size of native A. lavenia were higher than those of invasive species. Seeds of all species were positively photoblastic. At low temperature and in all levels of water stress, all measured parameters except mean germination time were the highest in A. houstonianum. However, at high temperature, there was no significant difference in germination percentage between A. houstonianum and A. lavenia. No germination of A. conyzoides and A. lavenia was recorded beyond −0.5 MPa water potential, but seeds of A. houstonianum germinated up to −0.75 MPa. A. houstonianum had higher root mass fraction, root‐to‐shoot ratio, and number of leaves than the other two species. Stem mass fraction and the height of seedling were highest in A. conyzoides. The RGR was 1.6 times higher in invasive Ageratum species than the native species; it was slightly higher in A. houstonianum than in A. conyzoides. Overall, the results suggest that germination traits and seedling growth performance can be used as predictors of a species' invasiveness.
Trends in the susceptibility of U.S.
Acinetobacter baumannii-calcoaceticus
species complex and
Stenotrophomonas maltophilia
isolates to minocycline, 2014–2021
Authors: Pfaller Michael A. , Shortridge Dee , Carvalhaes Cecilia G. , Castanheira Mariana 
Published: November 2023

ABSTRACT

Acinetobacter baumannii
-
calcoaceticus
species complex (ACB) and
Stenotrophomonas maltophilia
(SM) are opportunistic, non-fermentative organisms that can cause serious hospital-acquired infections in immunocompromised patients. These pathogens are inherently resistant to several common drug classes and often acquire other resistance mechanisms, making them difficult to treat. In this study, we analyzed the susceptibility of 1,029 contemporary ACB and 1,522 SM isolates to minocycline (MIN) and levofloxacin (LEV) as well as meropenem (MER) for ACB and trimethoprim-sulfamethoxazole (TMP/SMX) for SM using the CLSI broth microdilution method. Isolates were collected as a part of the SENTRY Antimicrobial Surveillance Program from 2014 to 2021. Pneumonia in hospitalized patients was the most common infection from which ACB (57.0%) and SM (73.9%) were isolated. MIN had the highest
in vitro
activity for ACB (86.2%) and SM (99.5%). The activity of ACB and SM to all three agents varied over the period studied. MIN activity to ACB decreased in 2020 (80.6%) but rebounded in 2021 (86.2%). LEV and MER showed an overall trend of increasing susceptibility for ACB, with slightly lower activity in 2020–2021. MIN and TMP/SMX (>98.3% and >93.7%, respectively) activities were stable against SM isolates. LEV activity decreased from 84.3% (2015) to 69.2% (2018). The activity of MIN remained stable and higher than other agents tested for both ACB and SM, pathogens that have limited therapeutic alternatives. These
in vitro
data suggest that MIN is a useful treatment option for infections caused by ACB or SM.

IMPORTANCE

Acinetobacter baumannii-calcoaceticus
species complex and
Stenotrophomonas maltophilia
are opportunistic, non-fermentative Gram-negative organisms that can cause serious hospital-acquired infections in immunocompromised patients. These pathogens are inherently resistant to several common drug classes and often acquire other resistance mechanisms, making them difficult to treat. In this study, we analyzed the trends of susceptibility of over 2,500 U.S. bacterial isolates collected from hospitalized patients over an 8-year period to minocycline, which is used to treat infections caused by these pathogens. These
in vitro
data suggest that minocycline is a useful treatment option for infections caused by
Acinetobacter baumannii-calcoaceticus
species complex or
Stenotrophomonas maltophilia
.
Sciatic nerve palsy after direct anterior approach for total hip replacement
Authors: Prakash Saket , Rai Alok , Manhas Vikrant , Malhotra Rajesh 
Published: November 2023

SummarySciatic nerve injury after total hip replacement is rare with a reported incidence of about 0.09%–3.7%. The most commonly reported causes include traction on the nerve during reduction, compression of the nerve from subfascial haematoma, significant leg lengthening, improper retractor placement, thermal burns from cautery and extraneous cement. We present a case of complete sciatic nerve palsy in a patient operated on using direct anterior approach (DAA). To date, there are no reports describing sciatic nerve palsy secondary to haematoma immediately after primary arthroplasty through the DAA. We performed an MRI of lumbosacral spine with both hips, which revealed a haematoma. Consequently, we promptly took the patient to the operation theatre for re-exploration. Using the same approach, we dislocated the hip and removed the clots. By the end of 2 weeks, the patient was able to dorsiflex the ankle and had fully recovered from sciatic nerve palsy.
Half-wormholes and ensemble averages
Authors: Peng Cheng , Tian Jia , Yang Yingyu 
Published: November 2023

AbstractRecently, the concept of half-wormholes is introduced to give a resolution to the factorization puzzle in holography and help understand better the relation between ensemble average theories and gravity in the bulk. Half-wormholes are proposed to be the contributions to the gravitational path integral that correspond to fluctuations of each individual theory around the average of the whole ensemble of theories. In this paper, we further explore the extent to which the half-wormhole interpretation is applicable. In particular, to further demonstrate that the half-wormhole interpretation is not merely a feature of a specific theory but is a general feature of ensemble average theories, we examine various models, including different enriched 0-dimensional SYK-like models, the 1-dimensional Brownian SYK model and its generalization. To further demonstrate that the half-wormhole interpretation applies to more general probability distributions apart from the zero-mean Gaussian distribution, we consider random couplings with other non-trivial moments. Specifically, introducing a non-trivial mean value to the random coupling renders the spectral correlators to exhibit both disconnected saddles and connected saddles. The inclusion of higher-order moments leads to new “multi-linked half-wormhole” saddles. We also clarify the distinctions between the unlinked half-wormhole and the linked half-wormhole in our modified Brownian SYK model.
Mathematical Modeling Identifies Optimum Palbociclib-fulvestrant Dose Administration Schedules for the Treatment of Patients with Estrogen Receptor–positive Breast Cancer
Authors: Cheng Yu-Chen , Stein Shayna , Nardone Agostina , Liu Weihan , Ma Wen , Cohen Gabriella , Guarducci Cristina , McDonald Thomas O. , Jeselsohn Rinath , Michor Franziska 
Published: November 2023

AbstractCyclin-dependent kinases 4/6 (CDK4/6) inhibitors such as palbociclib are approved for the treatment of metastatic estrogen receptor–positive (ER+) breast cancer in combination with endocrine therapies and significantly improve outcomes in patients with this disease. However, given the large number of possible pairwise drug combinations and administration schedules, it remains unclear which clinical strategy would lead to best survival. Here, we developed a computational, cell cycle–explicit model to characterize the pharmacodynamic response to palbociclib-fulvestrant combination therapy. This pharmacodynamic model was parameterized, in a Bayesian statistical inference approach, using in vitro data from cells with wild-type estrogen receptor (WT-ER) and cells expressing the activating missense ER mutation, Y537S, which confers resistance to fulvestrant. We then incorporated pharmacokinetic models derived from clinical data into our computational modeling platform. To systematically compare dose administration schedules, we performed in silico clinical trials based on integrating our pharmacodynamic and pharmacokinetic models as well as considering clinical toxicity constraints. We found that continuous dosing of palbociclib is more effective for lowering overall tumor burden than the standard, pulsed-dose palbociclib treatment. Importantly, our mathematical modeling and statistical analysis platform provides a rational method for comparing treatment strategies in search of optimal combination dosing strategies of other cell-cycle inhibitors in ER+ breast cancer.Significance:We created a computational modeling platform to predict the effects of fulvestrant/palbocilib treatment on WT-ER and Y537S-mutant breast cancer cells, and found that continuous treatment schedules are more effective than the standard, pulsed-dose palbociclib treatment schedule.
Aristotle‐Only Direct Aspiration First‐Pass Technique (AO‐ADAPT) for Endovascular Mechanical Thrombectomy: A Technical Series of a Novel Technique Demonstrating Safety and Efficacy
Authors: Ares William J. , Chowdhry Shakeel , Tonetti Daniel A. , Salah Walid K. , Jankowitz Brian T. , Grandhi Ramesh 
Published: November 2023

Background
The introduction of soft, large‐profile microwires has improved aspiration catheter delivery for intracranial large‐vessel occlusions. The Aristotle‐only direct aspiration first‐pass technique (AO‐ADAPT) uses the Aristotle 24 microwire to deliver a large‐bore aspiration catheter to the target occlusion without a microcatheter. We characterized rates of technical success achieved using this technique for mechanical aspiration thrombectomy.

Methods
A retrospective review of prospectively collected thrombectomy databases at 4 academic institutions identified patients undergoing procedures in which AO‐ADAPT was used. Patient demographics, clinical considerations, technical details, and radiographic outcomes were collected. Rates of successful aspiration catheter delivery without adjunctive devices and of successful reperfusion (Thrombolysis in Cerebral Infarction≥2B) were collected.

Results
Forty‐five patients met inclusion criteria (mean age 72.2±13.2 years, 62.2% female; 71.1% M1 occlusions). With a first‐line AO‐ADAPT approach, 42/45 (93.3%) patients achieved Thrombolysis in Cerebral Infarction≥2B reperfusion, with first‐pass recanalization in 26/45 (57.8%). We delivered the aspiration catheter to the target occlusion without adjunctive device in 35/45 (77.8%) patients. Of these, 29 (82.9%) underwent successful contact aspiration. This entire cohort (64.4% of the population) achieved Thrombolysis in Cerebral Infarction≥2B, with a mean time to reperfusion of 16 minutes and a first‐pass recanalization rate of 66%. Of the 16 patients who did not achieve successful AO‐ADAPT reperfusion, 6 needed a microcatheter for aspiration catheter delivery but underwent successful contact aspiration, 6 achieved microcatheter‐free delivery but needed a stentriever for final recanalization, and 4 required both microcatheter for delivery and stentriever for final recanalization. No intracranial vascular complications occurred during the procedures; 1 patient (2.2%) experienced symptomatic intracranial hemorrhage secondary to reperfusion injury.

Conclusion
The AO‐ADAPT approach to mechanical thrombectomy safely and effectively achieved reperfusion for patients with large‐vessel occlusions, with first‐pass success and successful recanalization rates comparable with other techniques. For most cases in this series, this technique obviated the need for a microcatheter and/or stentriever.
Comparing the Accuracy of Motor Reproduction and Timeline Estimation Methods for Interval Timing in Children
Authors: Hallez Quentin 
Published: November 2023

Abstract
This brief report aims to compare the performance of motor reproduction and timeline estimation tasks in two groups of children aged 5–6 and 7–8 years old. The study included 80 children and used a computer-based experiment with two sessions for each method. The findings suggest that motor reproduction and timeline estimation tasks differ in accuracy and variability, with timeline estimation yielding more accurate and less variable estimates. These differences between the two tasks are even more pronounced in younger children. The discussion highlights the importance of using the timeline estimation task for future research on children’s time perception.
Projecting Future Energy Production from Operating Wind Farms in North America. Part III: Variability
Authors: Coburn Jacob , Pryor Sara C. 
Published: November 2023

Abstract
Daily expected wind power production from operating wind farms across North America are used to evaluate capacity factors (CF) computed using simulation output from the Weather Research and Forecasting (WRF) Model and to condition statistical models linking atmospheric conditions to electricity production. In Parts I and II of this work, we focus on making projections of annual energy production and the occurrence of electrical production drought. Here, we extend evaluation of the CF projections for sites in the Northeast, Midwest, southern Great Plains (SGP), and southwest U.S. coast (SWC) using statewide wind-generated electricity supply to the grid. We then quantify changes in the time scales of CF variability and the seasonality. Currently, wind-generated electricity is lowest in summer in each region except SWC, which causes a substantial mismatch with electricity demand. While electricity of residential heating may shift demand, research presented here suggests that summertime CF are likely to decline, potentially exacerbating the offset between seasonal peak power production and current load. The reduction in summertime CF is manifest for all regions except the SGP and appears to be linked to a reduction in synoptic-scale variability. Using fulfillment of 50% and 90% of annual energy production to quantify interannual variability, it is shown that wind power production exhibits higher (earlier fulfillment) or lower (later fulfillment) production for periods of over 10–30 years as a result of the action of internal climate modes.

Significance Statement
Electrical power system reassessment and redesign may be needed to aid efficient increased use of variable renewables in the generation of electricity. Currently wind-generated electricity in many regions of North America exhibits a minimum in summertime and hence is not well synchronized with electricity demand, which tends to be maximized in summer. Future projections indicate evidence of reductions in wind power during summer that would amplify this offset. However, electrification of heating may lead to increased wintertime demand, which would lead to greater synchronization.
Plumbagin Attenuates Ovalbumin-induced Allergic Asthma in Mice through Inhibition of Inflammatory Response
Authors: Yiming Dong , Alzahrani Abdullah R , Mohideen Abubucker Peer 
Published: November 2023

Background Asthma is a prominent non-communicable inflammatory disease that affects both children and the elderly. Younger people are more prone to asthma, and most prescribed anti-asthmatic medicines relieve symptoms but do not cure the condition completely. We investigated the ability of a phytochemical plumbagin to alleviate ovalbumin (OVA)-induced asthma in BALB/c mice. Materials and Methods The allergic asthma-induced mice were treated with two different doses of 25 and 50 mg/kg bwt plumbagin, and to compare the efficacy of plumbagin, a standard drug dexamethasone treatment was given. OVA-specific IgE and eotaxin were quantified to determine the induction of asthma and the inhibitory role of plumbagin. Total leukocyte and differential count were done to assess the effect of plumbagin on inflammatory cells. Inflammatory cytokines inducing both atopic and non-atopic asthma were quantified to examine the efficacy of plumbagin against allergic and non-allergic-induced asthma. Nitric oxide (NO) and myeloperoxidase activity were measured to investigate the anti-asthmatic potential of plumbagin. The antioxidant potency of plumbagin was assessed by quantifying the levels of antioxidants and the oxidative stress marker malondialdehyde. Lung weight index and histopathological analysis of lung tissue were done to confirm the ameliorative potency of plumbagin against OVA allergen-induced asthma. Results Plumbagin treatment significantly decreased the status of OVA-specific IgE and eotaxin, thereby prevented the eosinophilic infiltration. It also inhibited the synthesis of both atopic and non-atopic inducing inflammatory cytokines. Plumbagin treatment also increased the levels of antioxidants and prevented the lung tissue damage, which was evidenced with our histopathology study of lung tissue. Conclusion Overall, our finding confirms that plumbagin is persuasively alleviated OVA allergen-induced asthma complications in mice model and may be an alternative for currently available anti-asthmatic drugs.