bluuebunny/crossref_metadata_2025_split huggingface dataset:
Preclinical models for studying corticosteroid‐induced osteonecrosis of the femoral head
Authors: Tsubosaka Masanori , Maruyama Masahiro , Lui Elaine , Kushioka Junichi , Toya Masakazu , Gao Qi , Shen Huaishuang , Li Xueping , Chow Simon Kwoon‐Ho , Zhang Ning , Yang Yunzhi Peter , Goodman Stuart B. 
Published: December 2023

AbstractNontraumatic osteonecrosis of the femoral head (ONFH) is a refractory condition that commonly results in femoral head collapse and degenerative arthritis of the hip. In the early stages, surgical procedures for hip preservation, including core decompression (CD), have been developed to prevent progressive collapse of the femoral head. Optimization of bone regeneration and biological augmentation may further enhance the therapeutic efficacy of CD for ONFH. Thus, combining CD with cell‐based therapy has recently been proposed. In fact, patients treated with cell‐based therapy using autologous bone marrow concentrate demonstrate improved survivorship of the femoral head, compared with conventional CD alone. Preclinical research studies to investigate adjunctive therapies for CD often utilize the rabbit model of corticosteroid‐induced ONFH. Mesenchymal stem cells (MSCs) are known to promote osteogenesis and angiogenesis, and decrease inflammation in bone. Local drug delivery systems have the potential to achieve targeted therapeutic effects by precisely controlling the drug release rate. Scaffolds can provide an osteoconductive structural framework to facilitate the repair of osteonecrotic bone tissue. We focused on the combination of both cell‐based and scaffold‐based therapies for bone tissue regeneration in ONFH. We hypothesized that combining CD and osteoconductive scaffolds would provide mechanical strength and structural cell guidance; and that combining CD and genetically modified (GM) MSCs to express relevant cytokines, chemokines, and growth factors would promote bone tissue repair. We developed GM MSCs that overexpress the anti‐inflammatory, pro‐reconstructive cytokines platelet‐derived growth factor‐BB to provide MSCs with additional benefits and investigated the efficacy of combinations of these GM MSCs and scaffolds for treatment of ONFH in skeletally mature male New Zealand white rabbits. In the future, the long‐term safety, efficacy, durability, and cost‐effectiveness of these and other biological and mechanical treatments must be demonstrated for the patients affected by ONFH.
Aluminum complexes of a hemilabile pyrrolylaldiminate ligand
Authors: Lee Pei‐Ying , Lin Yu‐Hsuan , Liang Lan‐Chang 
Published: December 2023

AbstractOverviewThis study describes the synthesis, characterization, and reactivity of aluminum complexes containing the amine‐functionalized pyrrolylaldiminate ligand N‐(2‐dimethylaminoethyl)‐5‐tert‐butyl‐pyrrol‐2‐ylaldiminate ([PyImN]−).SynthesisThe condensation reaction of N,N‐dimethylethylenediamine with 5‐tert‐butylpyrrole‐2‐carbaldehyde in methanol at room temperature produces H[PyImN]. Alkane elimination reactions of MeAlCl2 with H[PyImN] in toluene at 110°C and AlR3 (R = Me, Et) with H[PyImN] in toluene at −35°C afford [PyImN]AlCl2 and [PyImN]AlR2, respectively.CharacterizationSolution NMR studies reveal the coordination preferences of [PyImN]—whose hemilabile amine donor is bound to the aluminum center in [PyImN]AlCl2 but unbound in [PyImN]AlR2 (R = Me, Et).CatalysisThe catalytic activities of [PyImN]AlMe2 in controlled ring‐opening polymerization of ε‐caprolactone are discussed.
Experiential learning in engineering education: A systematic literature review
Authors: Tembrevilla Gerald , Phillion André , Zeadin Melec 
Published: December 2023

AbstractBackgroundThe evolving transformations of our society at large, academic institutions, and engineering discipline in the 21st century have profound implications for the nature of experiential learning being offered in engineering education. However, what is experiential learning in the context of engineering education?PurposeThe introduction and evaluation of experiential learning in undergraduate engineering education between 1995 and 2020, as well as the essential elements for consideration in its future implementation, have been analyzed and synthesized.Design/MethodA population–intervention–comparison–outcome framework and PRISMA flow diagram were used to outline a systematic literature review on how experiential learning was introduced into undergraduate engineering curricula, how it was evaluated, and the essential elements for consideration in its future implementation.FindingsA total of 220 studies were synthesized. These studies offered a new lens of seeing experiential learning, which were interpreted as “paradigm shifts.” More than one‐half of the total studies were conducted between 1995 and 2005. These studies were strongly directed at measuring student performance and occurred in a decade when many North American engineering curricula were being restructured. The review indicated that experiential learning has been successfully carried out via diverse methodologies. However, there is a strong need to enrich it with a theoretical basis.ConclusionsExperiential learning introduced into engineering education appeared to be an interdependent self–school–community entity. In the changing work environment of the 21st century, heightened by the impacts of the COVID‐19 pandemic, invoking the inseparability of self, school, and community would provide unique perspectives to our evolving understanding of experiential learning and its relevance in engineering discipline.
Measles in vulnerable populations: An outbreak in Roma settlements of Loire‐Atlantique, France, 2019
Authors: Lefebvre M. , Gross L. , Ollivier R. , Bailly S. , Coste‐Burel M. , Coutherut J. , Dina J. 
Published: December 2023

AbstractIn May 2019, a measles outbreak occurred in the French subregion of Loire‐Atlantique, particularly affecting Roma settlements. Various obstacles hindered the implementation of postexposure measures among Roma population, resulting in the spread of the cases to other settlements. Suspected cases of measles were immediately investigated and concerned settlements were visited for measles–mumps–rubella (MMR) vaccination. From July 1 to September 3, 2019, a first and then a second Health Reserve team helped for vaccination on the affected and then also the measles‐free settlements. Vaccination uptake was monitored with the use of the department's vaccination center immunization registry. Genotyping of selected samples was performed for comparison with viruses circulating at the same time in France and Romania. As of September 16 2019, 109 cases of measles were confirmed among Roma population, including 99 (91%) children under 15 years. Of the 85 people eligible for vaccination, 60 (71%) had not been vaccinated and 23 (27%) had an unknown vaccination status. Sequence comparison revealed that 28/29 sequenced D8 strains were 100% identical to the strain responsible for a large number of cases throughout France in 2019, and to two sequences reported in Romania among sporadic cases. The vaccination campaign resulted in 1136 people on 35 settlements receiving at least one dose of MMR vaccine and in the increase of one‐dose MMR vaccine coverage at 24 months from 43% (23/53) to 91% (48/53). With measles transmission continuing in Europe, efforts must be made to meet immunization coverage targets, particularly in hard‐to‐reach communities where outbreaks may be difficult to control.
Coastal Lagoonal Evolution within the Early Holocene Humber Estuary, eastern England
Authors: Grant M. J. , Hill T. , Evans S. , Law M. 
Published: December 2023

ABSTRACTRapid sea‐level rise during the Early Holocene around the North Sea coastal lowlands provided conditions under which estuarine and coastal features, with no modern equivalents, could be created. Investigation of nearshore sediments within the Outer Humber Estuary, UK, has identified a tidal lagoonal system, created between c. 9000 and 7800 cal a bp. These sequences show the initial flooding of a carr woodland, prior to the establishment of more saline conditions as the tidal lagoonal system developed. Inter‐core comparisons, based on diatom and pollen analyses, suggest variations in the structure of a tidal lagoon setting, which probably lasted for only a brief period before being submerged by rising sea levels. The absence of an erosive contact in several of the sequences studied has permitted the creation of the oldest sea‐level index points for the Outer Humber Estuary, providing validation for the current glacial isostatic adjustment models for the region.
Semi‐supervised liver segmentation based on local regions self‐supervision
Authors: Lou Qiong , Lin Tingyi , Qian Yaguan , Lu Fang 
Published: December 2023

AbstractBackgroundSemi‐supervised learning has gained popularity in medical image segmentation due to its ability to reduce reliance on image annotation. A typical approach in semi‐supervised learning is to select reliable predictions as pseudo‐labels and eliminate unreliable predictions. Contrastive learning helps prevent the insufficient utilization of unreliable predictions, but neglecting the anatomical structure of medical images can lead to suboptimal optimization results.PurposeWe propose a novel approach for semi‐supervised liver segmentation using contrastive learning, which leverages unlabeled data and enhances the suitability of contrastive learning for liver segmentation.Method and materialsContrastive learning helps prevent the inappropriate utilization of unreliable predictions, but neglecting the anatomical structure of medical images can lead to suboptimal optimization results. Therefore, we propose a semi‐supervised contrastive learning method with local regions self‐supervision (LRS2). On one side, we employ Shannon entropy to distinguish between reliable and unreliable predictions and reduce the dissimilarity between their representations within regional artificial units. Within each unit of the liver image, we strongly encourage unreliable predictions to acquire valuable information pertaining to the correct category by leveraging the representations of reliable predictions in their vicinity. On the other side, we introduce a dynamic reliability threshold based on the Shannon entropy of each prediction, gradually evaluating the confidence threshold of reliable predictions as predictive accuracy improves. After selecting reliable predictions, we sequentially apply erosion and dilation to refine them for better selection of qualified positive and negative samples. We evaluate our proposed method on abdominal CT images, including 131 images (train data: 77, validation data: 26, and testing data: 28) from 2017 ISBI Liver Tumors Segmentation Challenge.ResultsOur method obtains satisfactory performance in different proportion by exploiting the unreliable predictions. Compared with the result of VNet only under supervised settings (with 10, 30, 50, 70% and full labeled data), LRS2, respectively, brings an improvement of Dice coefficient by +6.11, +3.55, +4.43, and +2.25%, achieving Dice coefficients of 93.44, 93.31, 94.85, and 95.12%, respectively.ConclusionIn this study, we carefully select appropriate positive and negative samples from reliable regions, ensuring that anchor pixels within unreliable regions are correctly assigned to their respective categories. With a consideration of the anatomical structure present in CT images, we partition the image representations into regional units, enabling anchor pixels to capture more precise sample information. Extensive experiments confirm the effectiveness of our method.
Influence of normal stress‐induced three‐dimensional rough fracture aperture heterogeneity on nonlinear seepage‐heat transfer coupling processes
Authors: Zhang Ze , Wang Shuhong , Han Bowen , Dong Furui , Hou Qinkuan 
Published: December 2023

AbstractA clear understanding of the dependence of the heat transfer process on the flow field in three‐dimensional (3D) rough fractures is crucial for many underground projects. In this study, 3D rough rock fractures with heterogeneous apertures and mechanical effects are established. Navier‐Stokes flow and local heat balance theory are used to simulate the seepage‐heat transfer coupling process. Five normal stresses and five flow velocities are set to quantify the influence of aperture variability on the flow field and heat transfer behavior of the fractures. The results show that the change in fracture aperture caused by normal stress is the direct cause of the nonlinear distribution of the flow field and temperature fluctuation. A quantitative parameter of temperature fluctuation degree in the fracture is proposed, which decreases exponentially with increasing fracture aperture and increases with greater flow velocity. An empirical model is established to describe the relationship between the heat transfer coefficient and the ratio of hydraulic aperture to mechanical aperture. The correctness of the model is verified by published seepage‐heat transfer coupling test results. The model is extended to establish the relationship between the heat transfer coefficient and the volume fraction of eddy. It is confirmed that the heat transfer coefficient increases with the augmentation of nonlinear flow, and the reason why the results of evaluating the heat transfer coefficient by roughness alone in related experiments are inconsistent is revealed. The results enhance the understanding of convective heat transfer characteristics in 3D rough rock fractures.
Autologous platelet rich plasma (A‐PRP) combined with pelvic floor muscle training for the treatment of female stress urinary incontinence (SUI): A randomized control clinical trial
Authors: Saraluck Apisith , Chinthakanan Orawee , Kijmanawat Athasit , Aimjirakul Komkrit , Wattanayingcharoenchai Rujira , Manonai Jittima 
Published: December 2023

AbstractImportanceAutologous platelet‐rich plasma (A‐PRP) injection is a novel intervention for stress urinary incontinence (SUI) in women. However, no Phase II clinical trial has compared the outcomes of A‐PRP injection combined with pelvic floor muscle training (PFMT) with those of PFMT alone in these women.ObjectiveThe primary aim was to compare the efficacy of A‐PRP + PFMT versus PFMT alone in women with SUI. The secondary aim was to determine any adverse effects of A‐PRP injection.DesignRandomized clinical trial, single‐blind assessment.SettingUrogynecology clinic at a tertiary medical center.ParticipantsWomen with previously untreated SUI. Women in whom there was any suspicion of urgency, those with an Overactive Bladder Symptoms Score of ≥1, and those with obesity, pelvic organ prolapse, thrombocytopenia, or coagulopathy were excluded.InterventionsTwo injections of A‐PRP were administered with a 1‐month interval between injections in the A‐PRP injection + PFMT group. Both groups received PFMT.Main Outcomes and MeasuresThe primary outcome was determined using the 1‐h pad weight test (PWT). Secondary outcomes were measured using the Incontinence Quality of Life Questionnaire, item 11 on the International Consultation on Incontinence Questionnaire‐Female Lower Urinary Tract Symptoms questionnaire, Patient Global Impression of Improvement, and the percentage subjective improvement score.ResultsData for 60 study participants were available for analysis (A‐PRP + PFMT group, n = 31; PFMT group, n = 29). The 1‐h PWT decreased significantly in the A‐PRP + PFMT group but only slightly in the PFMT group at the 5‐month follow‐up. There was a statistically significant between‐group difference in the 1‐h pad weight of about 8 g in favor of the A‐PRP + PFMT group. A statistically significant difference in symptoms of SUI measured by the questionnaires was found between the A‐PRP + PFMT group and the PFMT group at the 2‐ and 5‐month follow‐up assessments. There were no reports of adverse events following injection of A‐PRP.Conclusions and RelevanceA‐PRP + PFMT could be a treatment option for women with SUI. Large Phase III randomized controlled trials are required to confirm our findings.
The correlation between sadomasochists' experience and their sadomasochistic behaviors and fantasies: A qualitative analysis of interviews
Authors: Liang Wanying , Zhang Yuqing 
Published: December 2023

AbstractLacking a comprehensive understanding of sadomasochism makes difficulties in judicial dispositions, clinical interventions, and mental health services. This study explores the correlation between sadomasochists' growth experience and their sadomasochistic behaviors and fantasies. We interviewed 51 sadomasochists from a Chinese subcultural website, coded and analyzed the interview records, conducted correlation and cluster analyses on the reference points of the nodes of impressive experience and sadomasochistic behaviors and fantasies, and constructed the model of Experience—Behaviors and Fantasies. We found that sadomasochists' typical impressive experiences are family parenting and sexual experience; sadomasochistic behaviors and fantasies can be classified into five categories: spirit, punishment, sex, canine, and excretion; and sadomasochistic behaviors and fantasies are partially correlated with sadomasochists' impressive experiences, indicating psychoanalytic theory is the leading theory for the driving processes of sadomasochism, while behaviorist and Gestalt theories also contribute.
Pulmonary embolism induces pneumonia‐like lung injury beyond pulmonary infarction
Authors: Wang Yue , Liu Bo , Zhou Chuming , Wang Yuan , Miao Jianing , Zhao Li 
Published: December 2023

AbstractPatients with pulmonary embolism (PE) commonly manifest concomitant “pneumonia,” which is generally believed to be either a cause (infection) or a consequence (infarction) of PE. This study aimed to clarify the relationship between PE and “pneumonia‐like” lesions beyond pulmonary infection and infarction. Chest computed tomography (CT) images of patients with PE and deep vein thrombosis (DVT) were retrospectively analyzed to compare the incidence of pneumonia lesions. The pathological damage and wet/dry ratio of lung tissues were observed in PE rats and PE plasma‐injected rats. In total, 793 and 914 inpatients were enrolled in the PE and DVT groups, respectively. Pneumonia lesions were observed in 36.9% and 26.3% of patients in the PE and DVT groups, respectively (p < 0.0001). Among PE rats, 33.3% exhibited focal severe lung injury, which closely resembled the pathological damage of community‐acquired pneumonia. The wet/dry ratio was significantly higher in the PE group than in the PE‐control group (4.98 ± 0.08 vs. 4.39 ± 0.06, p < 0.0001). Among PE plasma‐injected rats, individuals with focal proven lung injury were found at all experimental points, with an incidence of 27.6%. The lung wet/dry ratio was significantly higher in the PE plasma group than in the PE‐control plasma group at 1 and 2 h postinjection (5.02 ± 0.12 vs. 4.61 ± 0.06 and 4.76 ± 0.16 vs. 4.34 ± 0.09, respectively; p < 0.05). In conclusion, the manifestation of pneumonia lesions in chest CT images was higher among PE patients than among DVT patients. Plasma of PE rats could induce focal pneumonia‐like lung injury in healthy rats.
Tackling the activity and selectivity challenges of electrocatalysts toward the CO2RR via biatom catalysts on the 2D extended phthalocyanines
Authors: Wang Junyou , Wu Manhong , Zhao Bin , Wan Rui , Li Zhongyao 
Published: December 2023

AbstractThe development of efficient CO2 electrocatalytic reduction catalysts has become increasingly important. However, addressing issues related to activity and selectivity remains challenging due to the lack of robust design criteria. Organometallic sheets, characterized by their high surface area and well‐dispersed metal sites, offer a unique platform for catalysis. In this study, we employed large‐scale density functional theory calculations to investigate the transition metal dimers doped two‐dimensional extended phthalocyanines (TM2‐Pcs) as the biatom catalysts for the electrocatalysis of the CO2 reduction reaction (CO2RR). After systematical studies, the four catalysts of Mo2‐Pc, W2‐Pc, Ti2‐Pc, and Re2‐Pc were determined from 26 different TM2‐Pcs. Among them, Mo2‐Pc, Ti2‐Pc, and W2‐Pc have not only high faradaic efficiency (FE) but also small limiting potentials of reducing CO2 to CH4. Besides, the limiting potentials for the reduction of CO2 to CH2CH2 on Mo2‐Pc and Re2‐Pc fall within the range of −1.4 to −.8 V versus reversible hydrogen electrode. They demonstrate higher FE than the experimental results obtained on Cu(111). This work not only expands the possibilities for discovering more effective CO2 reduction catalysts but also provides a feasible strategy for the rational design of electrocatalysts CO2RR.
Initial stability of cementless acetabular cups using robotic‐assisted total hip arthroplasty compared with the conventional manual technique: An in vitro biomechanical study
Authors: Hidaka Ryo , Matsuda Kenta , Mochizuki Hidetaka , Kawano Hirotaka 
Published: December 2023

AbstractBackgroundThe aim of this study is to determine whether the initial stability of a cementless cup with the Mako system is superior to that of a conventional manual technique using bone models.MethodsThe bone models were prepared using a polyurethane foam block. Two hemispherical cementless cups (highly porous titanium cup [Trident II Tritanium, Stryker] and hydroxyapatite‐coated titanium cup [Trident HA, Stryker]) were implanted using the Mako system. The torque of the cups was measured by rotational and lever‐out torque testing and compared with that of a conventional manual technique.ResultsThe two types of cups that were implanted using the Mako system demonstrated significantly higher mean rotational torque than that of the manual technique (p < 0.01, p = 0.01, respectively).ConclusionsThis study provides the advantage of the initial stability of a cementless hemispherical cup implanted by the Mako system compared with that of the conventional manual technique.
Asynchronous event‐triggered adaptive robust switching filtering for nonlinear industrial cyber physical systems under data injection attacks
Authors: Qin Yanfei , Sun Ziwen 
Published: December 2023

AbstractBy fully taking the effects of data injection attacks and nonlinear disturbances into consideration, based on dynamic asynchronous event‐triggered approach, an adaptive robust H‐Infinity switching filtering (ARSF) method is proposed for the stability of industrial cyber physical systems. An adaptive feedback controller utilizing anticipated states and error‐dependent parameters can proficiently counteract the deleterious impacts of data injection attacks originating from the measurement channel. Furthermore, a filter, which includes the value of the measurement signal, is designed to monitor the system's state changes in real‐time and ensure the stable operation of the system under attacks. Based on the design of an adaptive feedback controller and a filter eliminating the effects of data injection attacks originating from the measurement channel, a switching scheme is further proposed for compensating the effect of data injection attacks in the control channel. Finally, simulation tests are conducted by using MATLAB to control the robustness of a practical quadrotor UAV system's angles by adopting ARSF, whose results verify that the correctness and effectiveness of the proposed ARSF.