bluuebunny/crossref_metadata_2025_split huggingface dataset:
'सफा हिमाल अभियान'मा नेपाली सेनाको भूमिका
Authors: बस्नेत गजेन्द्र बहादुर 
Published: February 2025

हिमालयको देश भनेर विश्वमै परिचित नेपालमा सर्वोच्च शिखर सगरमाथाका साथै आठ हजार मिटरभन्दा अग्ला आठ र छ हजारमाथिका १ हजार ३१० हिमाल छन् । यी हिमालमा सन् १९५० को दशकदेखि आरोहण सुरु भए यता क्रमिक रुपमा फोहोर थुप्रिदै जाँदा प्राकृतिक सुन्दरता बिग्रन थालेको छ । पर्यावरणको दृष्टिले संवेदनशील हिमालमा थुप्रिएको फोहोरको असर कम गर्न र सुन्दर हिमाललाई सुन्दर नै राखिराख्न सरकारले सन् २०१९ देखि ‘सफा हिमाल अभियान’ सुरु गर्‍यो । नेपाली सेनाको नेतृत्व र विभिन्न सरकारी, गैरसरकारी संघ संस्थाहरुसँगको सहकार्यमा थालिएको अभियानको पाँचौ“ संस्करण सकिँदासम्म १ लाख १९ हजार ५६ के.जी. फोहोर, १४ वटा मानव शव तथा केही अस्थिपञ्जर सङ्कलन गरिएको छ । अभियानका दौरान सेनाको योगदानलाई अझै कसरी परिष्कृत बनाउन सकिन्छ भन्ने अनुसन्धान गर्न यो अध्ययन गरिएको हो । प्राथमिक र द्वितीय स्रोतबाट संकलित तथ्याङ्कलाई विश्लेषण गरी तयार पारिएको यो लेख वर्णनात्मक, तुलनात्मक र गुणात्मक विश्लेषण शैलीमा आधारित छ । विभिन्न राष्ट्रिय, अन्तर्राष्ट्रिय प्रकाशन, सेना तथा अन्य सरकारी निकायका सामग्री/दस्तावेज र प्रत्यक्ष कुराकानीका आधारमा अध्ययन गरिएको छ । यसमा ‘सफा हिमाल अभियान’को इतिहास, अभियानमा सेनाले सम्पादन गरेका कार्यहरुको समीक्षा, हिमालको अवस्था, जलवायु तथा पर्यावरणीय असर, पर्यटनमा पार्ने प्रभावहरु समेटिएका छन् । सेनाको तालिमप्राप्त जनशक्ति र कुशल कार्यक्षमताकै कारण कठिन क्षेत्रबाट पनि फोहोर तथा शव संकलन र अभियानमा अपनाइएको संयुक्त व्यवस्थापनको मोडल सबल पक्ष देखिन्छ भने ‘पर्यटन उद्योग सेवा प्रवाह निर्देशिका २०७०’मा तोकिए अनुसार फोहोरको मुहान नियन्त्रण हुन नसक्नु कमजोर पक्ष देखिन्छ । सेनाको कुशल व्यवस्थापनका कारण अभियानपछि हिमाल सफाइमा केही हदसम्म टेवा पुगेको छ । तर फोहोरको मुहान खुल्ला राखेर गरिने सफाइले दीर्घकालीन रुपमा फोहोर व्यवस्थापन गर्न कठिन देखिन्छ ।
Progress toward hepatitis C virus elimination among people living with HIV–hepatitis C virus coinfection in Canada
Authors: El Sheikh Mariam Z , Young Jim , Panagiotoglou Dimitra , Cooper Curtis , Cox Joseph , Martel-Laferrière Valérie , Walmsley Sharon , Klein Marina B 
Published: February 2025

Background: Direct-acting antivirals (DAAs) for hepatitis C virus (HCV) were approved in Canada in 2013. By 2018, treatment restrictions had been lifted in all provinces, making DAAs universally accessible. Here, we aim to assess progress toward HCV elimination in the DAA era (2014–2022) within the Canadian Co-infection Cohort. Methods: The CCC is a multisite open cohort of people living with HIV-HCV coinfection with cohort visits scheduled biannually. We calculated annual cure rates overall by province and key population: gay bisexual and other men who have sex with men, people who inject drugs, and Indigenous peoples. Results: Among the 952 participants eligible for DAAs, 65% (n = 623) were cured and 3% (n = 26) achieved late clearance without treatment by the end of the study period. Of the 35% (n = 303) who were not cured, 46% (n = 138) were lost to follow-up, 31% (n = 95) died, and 23% (n = 70) had insufficient data to determine their cure status. Annual cure rates increased from 2014 to 2019 and then decreased across the cohort and in all key populations. From 2015 to 2018, gay bisexual and other men who have sex with men had the highest cure rates, but by 2019 people who inject drugs and Indigenous peoples caught up. Annual cure rates dropped in all provinces with the onset of the COVID-19 pandemic (after 2019). Conclusions: Universal accessibility of DAAs was an important step toward HCV elimination among people living with HIV-HCV coinfection, but this is not sufficient alone. Efforts are needed to re-engage those who remain uncured and reduce mortality in people living with HIV-HCV coinfection.
Discrete choice experiments and conjoint analyses in health screening programs for type 2 diabetes and liver disease: a scoping review
Authors: Cinque Felice , Long Clara , Dinh Duy A , Gore Genevieve , Swain Mark , Ramji Alnoor , Patel Keyur , Betel Michael , Bajaj Harpreet S , Dasgupta Kaberi , Poder Thomas G , Saeed Sahar , Sebastiani Giada 
Published: February 2025

Background: We aimed to summarize the evidence on the use of discrete choice experiments (DCEs) and conjoint analyses to quantify stakeholders’ preferences for screening programs for type 2 diabetes (T2D) and liver diseases, with a specific focus on metabolic dysfunction-associated steatotic liver disease (MASLD). Methods: For this scoping review, five databases (MEDLINE [PubMed], PubMed Central, EMBASE [Ovid], Europe PMC, Google Scholar) were searched with the assistance of a librarian, and deduplicated records were screened by two independent reviewers. Inclusion criteria: using DCE/CA, addressing screening programs for T2D and liver disease, published in English, French, or Spanish after January 1990. Results: Among 2,282 studies, 9 (7 from high- and 2 from low-income countries) elicited preferences for screening for liver disease (n = 1), hepatitis C (n = 1), hepatitis B (n = 1), hepatocellular carcinoma (n = 2), noncommunicable diseases (n = 2), diabetic retinopathy (n = 1), and cardiovascular diseases (n = 1). No studies addressed MASLD screening in T2D. Stakeholders included patients (n = 3), health care providers (n = 1), patients plus health care providers (n = 1), and the general population (n = 3). Studies used 18 structure, 6 process, and 4 outcome attributes. Screening sensitivity, setting, duration, provider, and cost were the most important structure attributes in participant choices. Physician support for treatment was the preferred process attribute. Outcome attributes were the least used, but of major importance (screening adherence followed by treatment) when considered. Conclusions: With no study focusing on MASLD screening in T2D, our scoping review highlights the need to develop a DCE addressing this topic to better design a patient-centred continuum of care.
Галофитті өсімдіктердің дамуына(NaCl) тұздардың түрлі концентрацияларының əсер
Authors: Ибрагимова Э.Қ. , Абдраимова Қ.Т. 
Published: February 2025

Қазіргі кездегі ғаламдық жылыну жылдамдығы қарқынды ұлғаюда. Климаттың өзгеруі өсімдіктержүйесін де көптеген өзгерістерге, экологиялық бейімделу деңгейінің нашарлауына, өсу динамикасының төмендеуіне, таралу ареалдарын өзгеруіне алып келуде. Сондықтан өсімдік қорларын сақтау жəне оларды тиімді пайдалану біздің ғаламшар үшін мемлекетаралық деңгейдегі аса маңызды мəселе. Түркістан аймағында кездесетін галофитті өсімдіктердің: гармала(адыраспан) Рeganum harmala, цикорий(шашыратқы) Cichorium, кермек сабын Limonium otolepis (Schrenk) Ktze, сол аймақ топырақ құрамына бейімделу дəрежесін анықтау мақсатында əртүрлі концентрациядағы тұз ерітіндісіндегі өнгіштігі анықталды. Шөптесін өсімдіктердің өсу ырғағына зертхана жағдайында бақылау жүргізу негізінде, үш өсімдік түрінің өскіндері мен тамырларының ұзындықтарына өлшеу жұмыстары жүргізілді. Шөптесін өсімдіктердің өсу ырғағына бақылау барысында кермек сабынның тұқымы, адыраспан мен шашыратқыға қарағанда, тұздың жоғарғы концентрациясында жақсыөнгіштік қасиетке ие екенін көрсетті. Зерттеу нəтижесі бойынша Түркістан аймағында кездесетін галофитті өсімдіктердің0,01 %-дық тұз концентрациясында аз мөлшерде болса да өнім беретіндігін көрсетсе, ал жоғары(1 %-дықNaCl) концентрациясында тұқым мүлдем өнбегендігін байқауға болады.
Kondisi sosial ekonomi dan pemanfaatan pekarangan oleh masyarakat kawasan hutan mangrove, Desa Bumi Dipasena Utama Kabupaten Tulang Bawang, Provinsi Lampung
Authors: Kambey Kevin Kornelius , Duryat Duryat , Maryono Tri , Rodiani Rodiani 
Published: February 2025

Pekarangan memberi potensi untuk meningkatkan ekonomi, perbaikan kualitas lingkungan, dan sosial masyarakat. Penelitian ini bertujuan untuk mengetahui bentuk pemanfaatan lahan pekarangan oleh petani tambak udang di Desa Bumi Dipasena Utama, Kabupaten Tulang Bawang. Penentuan responden dilakukan dengan metode Simple Random Sampling. Analisis data dilakukan dengan metode deskriptif analitik. Hasil penelitian menunjukan bahwa sebagian besar (64,3%) petani tambak di Bumi Dipasena berada pada usia dewasa madya (40—60 tahun). Berdasarkan jenis kelamin, semua petani tambak berjenis kelamin laki-laki. Petambak di bumi dipasena terdiri dari berbagai suku, yaitu suku Jawa, Lampung, Palembang, dan Melayu. Sebagaian besar (92,9%) petani tambak memiliki tingkat pendidikan sekolah menengah. Masyarakat bumi dipasena sebagian besar (78.6%) tidak memiliki pekerjaan sampingan. Berdasarkan kriteria BPS (2021) sebagian besar (78,6%) masyarakat di Bumi Dipasena Utama tergolong berpendapatan sedang. Seluruh petani tambak Bumi Dipasena memiliki lahan pekarangan seluas 1.000 m². Sebagian besar (57,1%) lahan pekarangan di Desa Bumi Dipasena Utama dimanfaatkan oleh masyarakat sebagai kebun pekarangan, diikuti oleh pemanfaatan untuk kandang ternak, taman, dan kolam ikan, dengan persentase berturut-turut adalah 42,8%, 21,4%, dan 7,1%. Tidak terdapat korelasi antara etnik dengan bentuk pemanfaatan lahan pekarangan oleh masyarakat.
Pengukuran Kinerja SDM Layanan Publik
Authors: Sijabat Saut Gracer 
Published: February 2025

Pengukuran kinerja pelayanan publik sering dikaitkan dengan pengukuran kinerja pemerintah, karena pelayanan publik merupakan bagian dari tanggung jawab pemerintah, sehingga ukuran kinerja pemerintah dapat dilihat dari kinerja pemerintah dalam memberikan pelayanan publik. Dalam rangka mewujudkan sistem pemerintahan dan pelayanan publik yang baik, efisien, efektif dan berkualitas, pegawai ASN harus profesional, bertanggung jawab, adil, jujur dan kompeten di bidangnya, sehingga pengukuran kinerja SDM layanan public juga menjadi penting. Dalam hal ini, penelitian dilakukan dengan menggunakan pendekatan kualitatif dengan teknik analisis konten, dimana pengukuran dilakukan dengan membandingkan aspek pada Laporan Kinerja Pemerintah (LKIP) dengan aspek pengukuran SDM pada penilaian unit pelayanan publik Kementerian PAN dan RB. Dengan membandingkan aspek pengukuran SDM dalam pelayanan publik antara Peraturan Menteri PAN dan RB No. 38 Tahun 2012 dengan Provinsi DKI Jakarta danÂ Jawa Barat, ditemukan adanya perbedaan pengukuran SDM. Meskipun Provinsi DKI Jakarta dan Jawa Barat menerima penghargaan Sinovik dengan menggunakan aspek pengukuran SDM yang sama, namun dalam hal operasional fungsi SDM, kedua Provinsi memiliki pengukuran yang berbeda. Rekomendasi berdasarkan hasil penelitian standardisasi dapat diimplementasikan di tingkat nasional dengan memasukkan aspek pengukuran SDM dari penilaian kinerja unit publik Peraturan Menteri PAN RB No. 38 Tahun 2012 ke dalam Key Performance Indicator/ Indikator Kinerja Utama (IKU) seluruh instansi pemerintah, baik pusat dan daerah, sedangkan indikator selain Peraturan Menteri PAN dan RB No. 38 Tahun 2012 yang digunakan oleh instansi pusat dan daerah digunakan sebagai Indikator Kinerja Tambahan (IKT).Kata Kunci: Pengukuran Kinerja, Kinerja SDM, Layanan Publik
Inovasi Layanan Perpustakaan di Masa Pandemi Covid-19 Studi Kasus di Perpustakaan Nasional RI
Authors: Syaifuddin Syaifuddin , Rosya Susmelawati Rosya , Wamea Santi , Sigit Yustinus Sudono , Wiyono Edi , Hamka Hamka 
Published: February 2025

Â Perpustakaan Nasional Republik Indonesia (Perpusnas) sebagai lembaga pemerintah non kementerian yang memberikan layanan publik di bidang Perpustakaan. Era new normal sebagai akibat dari pendemi covid-19 mengharuskan Perpustakaan Nasional Â untuk berinovasi agar layanan prima dapat diberikan kepada masyarakat. Penelitian ini bertujuan untuk memberikan gambaran tentang penerapan best practice di Perpustakaan Nasional dalam berinovasi mengembangkan layanan pada masa pandemi Covid-19 dan kenormalan baru. Penelitian ini menggunakan pendekatan kualitatif dengan metode wawancara mendalam terhadap pejabat structural, pejabat fungsional dan masyarakat sebagai pengguna layanan Perpustakaan Nasional. Hasil penelitian minimal ada dua hal yaitu 1). Perpustakaan Nasional merupakan Lembaga publik yang memberikan pelayanan di era kenormalan baru untuk memenuhi harapan masyarakat terkait adanya kepastian pelayanan perpustakaan, responsivitas pelayanan dan kejelasan informasi pelayanan untuk umum yang berbasis Prokes untuk mencegah penyebaran virus Covid-19 sehingga diperlukan adanya inovasi-inovasi layanan; 2).Inovasi layanan yang dibuat adalah menyusun panduan dan pedoman layanan Â Perpustakaan di masa kenormalan baru (pandemi covid-19) dengan membuat Â SOP khusus pelayanan perpustakaan nasional di masa pandemi dan menyediakan layanan secara online, mengoptimalkan pemanfaatan koleksi digital dan layanan online yang sudah ada, seperti iPusnas, e-resources, IOS, dan Khastara, memperkuat kesiapan sistem jaringan, sarana prasarana, dan SDM untuk mendukung ketersediaan layanan online, Penyediaan fasilitas bookdrop untuk pengembalian buku, penyediaan zoom meeting gratis bagi masyarakat yang ingin menyelenggarakan seminar online dan penyediaan layanan referensi melalui fitur â€œTanya Pustakawanâ€.Kata kunci: Inovasi, pelayanan perpustakaan, pandemi Covid-19
EVALUASI PENERAPAN APLIKASI NASKAH DINAS ELEKTRONIK (NADINE) BAGI PENINGKATAN PRODUKTIVITAS KERJA PEGAWAI DI BIRO UMUM SEKRETARIAT JENDERAL KEMENTERIAN ENERGI DAN SUMBER DAYA MINERAL
Authors: Untari Lina Widi , Tumanggor Budi Fernando 
Published: February 2025

Kementerian Pendayagunaan Aparatur Negara dan Reformasi Birokrasi (KemenPAN&RB) mengeluarkan aturan penyesuaian sistem jam kerja bagi seluruh Aparatur Sipil Negara (ASN) di Indonesia hingga saat ini. Perubahan metode kerja dari konvensional ke papperless/digital government karena ada tuntutan pandemi. Karena adanya perkembanganÂ kebutuhan peningkatan pelayanan publik sebagai pengembanganÂ digital government dalam peningkatan produktivitas kerja dan pelayanan publik yang lebih optimal. Salah satu aplikasi digital atau elektronik dalam hal persuratan yang digunakan dan dioptimalkan oleh Kementerian ESDM ini adalah Naskah Dinas Elektronik (yang disingkat dengan NADINE). Metode penelitian yang digunakan metode penelitian deskriptif kualitatif. Teknik pengumpulan data yang digunakan dalam penelitian ini adalah menggunakan data primer melalui wawancara dan data sekunder melalui observasi dan telaah dokumen. Analisis data yang digunakan dalam penelitian ini adalah reduksi data, penyajian data, dan penarikan kesimpulan. Hasil penelitian menunjukkan bahwa aplikasi NADINE di Biro Umum, Sekretariat Jenderal, Kementerian Energi dan Sumber Daya Mineral sangat efektif dan efisien untuk menunjang keberhasilan organisasi dalam mewujudkan implementasi e-government karena dapat meningkatkan kualitas kerja, kuantitas kerja dan ketepatan waktu bagi pegawai untuk mewujudkan pelayanan prima dalam pelayanan publik baik internal maupun eksternal.Kata Kunci: Naskah Dinas Elektronik (NADINE), produktivitas pegawai, elektronik government
Inventarisasi Arthropoda pada Tanaman Tebu (Saccharum officinarum L.) Di Tiga Umur Tanaman yang Berbeda
Authors: Abidin Zainal , Dwy Ushardyna Funky , Lukman Hakim Arief 
Published: February 2025

Sugarcane (Saccharum officinarum L.) is a national sugar-producing plant. One of the declines in sugar production is caused by pests and diseases and improper control. The study aims to make an inventory of arthropods in sugarcane at the age of 1,5 – 3 months, 4 – 10 months, and < 11 months in order to obtain information on these matters. The research was carried out in three plantation areas in Sumber Perkul, Gedangan, Malang and at the Basic Laboratory of the Universitas Islam Raden Rahmat Malang during March – May 2022. This study used the relative method (Sticky yellow traps, pitfall traps, light traps) and the absolute method (visual control). The results of this 14.932 individu, study obtained 68 families from the Arachnida and Insecta classes, with groups of predatory roles, parasitoids, herbivores and others. The Important Value Index of dominant natural enemies (Parasitoid) Dolichopodidae (45%), Detritivor arthropod (Drosophilidae) and Polinator arthropod (Noctuidae) (26%), Herbivora arthropod Delphacidae (15%), and natural enemies (Predator) Coccinelidae (14%). The conclusion is that from all the calculated indicators there is no group of arthropods that dominates, the diversity is moderate, and the distribution is evenly distributed. There is a change in composition, but in all indicators the calculation of the entire age of the sugarcane plant is still in the stable and balanced category.
KANDUNGAN MINERAL DAN LOGAM BERAT PADA BIOSALT RUMPUT LAUT Padina sp.
Authors: Riska Nurdiana , Suedy Sri Widodo Agung , Izzati Munifatul 
Published: February 2025

Indonesian is an archipelago that has abundant biological resources, one of which is seaweed. Seaweed is widely used by the community as a standard cake chart, agar and herbal medicinal ingredients. One of the potential of seaweed can produce mineral salts (biosalt). One of the seaweed Biosalt which has not been widely used is from Padina sp. Biosalt Padina sp. contains minerals needed by the human body. The purpose of this study was to determine the amount of salt yield obtained from seaweed Padina sp. and knowing the quality of salt from Padina sp. in terms of the content of macromineral (Ca and Mg), Micromineral (Fe, Mn and Zn) and heavy metals (Cu and Pb). Sampling of Padina sp. Seaweed conducted in Teluk Awur, Jepara. Extraction biosalt Padina sp. carried out at BSF Plant Laboratory, Department of Biology, FSM, UNDIP. Testing with the ICP-OES tool was carried out in the Physical Chemistry laboratory of FMIPA UNNES. Data analysis was descriptive qualitative by comparing the salt content of "biosalt" seaweed with table salt (control). The results showed that the total yield of seaweed biosalt was 9.44 gr / 100 gr or 9.44%. As for that the mineral content of Ca, Mg, Fe, Mn, and Zn in biosalt Padina sp. higher than in table salt. On the other hand, heavy metals Cu and Pb in biosalt Padina sp. lower than table salt. This shows that salt obtained from seaweed Padina sp. safe for humans because they have high mineral content and heavy metal levels which are still below the threshold (<2.0 mg / gr) Keywords: minerals, heavy metals, seaweed, biosalt.
Construction of a novel gene signature linked to ferroptosis in pediatric sepsis
Authors: Fan Mingyuan , Chen Meiting , Gao Yongqi , Jiang Huilin , Li Yanling , Zhu Gongxu , Chen Shengkuan , Xu Yiming , Chen Xiaohui 
Published: February 2025

IntroductionPediatric sepsis is a complex and life-threatening condition characterized by organ failure due to an uncontrolled immune response to infection. Recent studies suggest that ferroptosis, a newly identified form of programmed cell death, may play a role in sepsis progression. However, the specific mechanisms of ferroptosis in pediatric sepsis remain unclear.MethodsIn this study, we analyzed microarray datasets from pediatric sepsis and healthy blood samples to identify ferroptosis-associated genes. A protein-protein interaction (PPI) network analysis and histological validation were performed to identify key genes. Additionally, immune infiltration analysis was conducted to explore the correlation between immune cells, immune checkpoint-related genes, and key genes. A competing endogenous RNA (ceRNA) network was constructed to investigate potential regulatory mechanisms involving long non-coding RNAs (lncRNAs), microRNAs (miRNAs), and key ferroptosis-related genes.ResultsWe identified 74 genes associated with ferroptosis in pediatric sepsis. Among them, five key genes (MAPK3, MAPK8, PPARG, PTEN, and STAT3) were confirmed through PPI network analysis and histological validation. Immune infiltration analysis revealed significant interactions between immune cells and key genes. The ceRNA network provided insights into the regulatory relationships between lncRNAs, miRNAs, and ferroptosis-related genes.DiscussionThese findings enhance our understanding of the role of ferroptosis in pediatric sepsis and highlight potential therapeutic targets for future research and clinical interventions.
Prion protein fragment (106–126) activates NLRP3 inflammasome and promotes platelet-monocyte/neutrophil interactions, potentially contributing to an inflammatory state
Authors: Verma Rashmi , Kailashiya Jyotsna , Mukherjee Avijit , Chaurasia Rameshwar Nath , Dash Debabrata 
Published: February 2025

IntroductionPrion diseases are neurodegenerative disorders where infectious prion proteins (PrP) featuring an amyloidogenic amino acid sequence, PrP (106–126), accumulate in the brain leading to neuroinflammation while it can also access circulation by breaching the blood-brain barrier. Platelets are highly sensitive cells in blood, which have been widely employed as “peripheral” model for neurons. In addition to their stellar roles in hemostasis and thrombosis, platelets are also known to function as immune cells and possess necessary components of functional inflammasome. This study demonstrates that prion proteins drive inflammasome assembly in platelets and upregulate activity of caspase-1, a critical readout of functional inflammasomes.MethodsFlow cytometric analysis was performed to measure intracellular ROS levels, caspase-1 activity, and platelet-monocyte/neutrophil interactions. Microscopy was used to assess the co-localization of NLRP3 and ASC.ResultsInflammasome activation is fuelled by reactive oxygen species (ROS) generated in prion-stimulated platelets that eventually leads to formation of platelet-monocyte/neutrophil aggregates, which was prohibited by small-molecule inhibitors of either caspase-1 or ROS.DiscussionThus, in addition to their neurotoxic effects on neuronal cells and stimulation of pro-coagulant activity in platelets, prions also unleash an inflammatory response in the organism.
Molecular docking, free energy calculations, ADMETox studies, DFT analysis, and dynamic simulations highlighting a chromene glycoside as a potential inhibitor of PknG in Mycobacterium tuberculosis
Authors: Alruwaili Muharib , Elsaman Tilal , Mohamed Magdi Awadalla , Elderdery Abozer Y. , Mills Jeremy , Alruwaili Yasir , Hamza Siddiqa M. A. , Mekki Salma Elhadi Ibrahim , Alotaibi Hazim Abdullah , Alrowily Maily J. , Althobiti Maryam Musleh 
Published: February 2025

IntroductionTuberculosis (TB), caused by the Mycobacterium tuberculosis (M.tb), remains a serious medical concern globally. Resistant M.tb strains are emerging, partly because M.tb can survive within alveolar macrophages, resulting in persistent infection. Protein kinase G (PknG) is a mycobacterial virulence factor that promotes the survival of M.tb in macrophages. Targeting PknG could offer an opportunity to suppress the resistant M.tb strains.MethodsIn the present study, multiple computational tools were adopted to screen a library of 460,000 molecules for potential inhibitors of PknG of M.tb.Results and discussionsSeven Hits (1–7) were identified with binding affinities exceeding that of the reference compound (AX20017) towards the PknG catalytic domain. Next, the ADMETox studies were performed to identify the best hit with appropriate drug-like properties. The chromene glycoside (Hit 1) was identified as a potential PknG inhibitor with better pharmacokinetic and toxicity profiles rendering it a potential drug candidate. Furthermore, quantum computational analysis was conducted to assess the mechanical and electronic properties of Hit 1, providing guidance for further studies. Molecular dynamics simulations were also performed for Hit 1 against PknG, confirming the stability of its complex. In sum, the findings in the current study highlight Hit 1 as a lead with potential for development of drugs capable of treating resistant TB.