bluuebunny/crossref_metadata_2025_split huggingface dataset:
A new species of Urocleidoides Mizelle & Price 1964 (Monogenea: Dactylogyridae) parasite of Hemiodus orthonops Eigenmann & Kennedy, 1903 (Hemiodontidae) from the upper Paraná River floodplain
Authors: Hasuike W.T. , Scorsim B. , Arjona I.S. , Bellay S. , de Oliveira A. V. , Takemoto R.M. 
Published: January 2024

Abstract
During the study of ectoparasites (Platyhelminthes) of fish in the floodplain of the Upper Paraná River - Brazil, a new species of Urocleidoides, present in the gill filaments of Hemiodus orthonops (Hemiodontidae), is described using morphological description and molecular data from the mitochondrial region of cytochrome c oxidase, subunit 1 (COI) and the partial region of the 28S rDNA gene. Urocleidoides luquei n. sp. differs from all its congeners by the presence of a filament that joins the accessory piece to the base of the male copulatory organ and resembles U. paradoxus and U. surianoae. Phylogenetic analyses using molecular data revealed that U. luquei n. sp. forms a paraphyletic group concerning the other Urocleidoides species. In this way, as well as contributing to the description of a new species, we seek to encourage and contribute to the increase in research using integrative taxonomy, thus making it possible to elucidate some unresolved questions about the genus Urocleidoides.
Soft institutions in Arctic governance—who does what?
Authors: Steinveg Beate , Rottem Svein Vigeland , Andreeva Serafima 
Published: January 2024

Abstract
The linkages between the Arctic and the rest of the world have become more profound and the region is increasingly attracting attention, also from non-Arctic state actors. Parallel to this development, the discussion about the future Arctic is taking place in various arenas, forums and among an increasing number of actors with interest in the region. At a time of high tension in international relations, and an increased likelihood of spill-over to Arctic cooperation, issues of governance of the Arctic region are potentially at stake. This makes it important that scholars are accurate in their analyses; confusing the mandate, responsibilities and purposes of different arenas for cooperation can be unfortunate. This article finds support in the literature on regime complexes and aims to show and analyse the differences between three key players in the Arctic: the Arctic Council, Arctic Frontiers and the Arctic Circle Assembly. In addition to exploring their differences, we ask what role these entities play in shaping policy in and for the Arctic. From mapping out the mandates, roles and responsibilities of the Arctic Council, Arctic Frontiers and Arctic Circle Assembly, and by nuancing their formal and informal aspects, we aim to contribute to clarifying misunderstandings regarding their functions and positions vis-à-vis each other.
Minding Creation: response to critics
Authors: Leidenhag Joanna 
Published: January 2024

AbstractIn this article, I reply to four responses published in this journal to my bookMinding Creation: Theological Panpsychism and the Doctrine of Creation. Two of these responses, by Christa L. McKirland and Eugene Fuimaono, and by Tim Miller and Thomas Jay Oord, are largely appreciative and propose future engagement with theological anthropology, indigenous perspectives, process metaphysics, and the doctrine of the incarnation. The other two responses, by Andrei Buckareff and Philip Goff, offer critical engagement on arguments I made regarding the relationship between panpsychism, naturalism, and theism.
Original sin, control, and divine blame: some critical reflections on the moderate doctrine of original sin
Authors: Visala Aku , Vainio Olli-Pekka 
Published: January 2024

AbstractThis article examines a construal of the doctrine of original sin which affirms the cognitive corruption of human faculties but denies that humans carry original guilt for Adam's fall or for cognitive corruption. All humans require Christ's atonement, because they either inevitably commit at least one sin or are rejected by God for other reasons. We go on to identify three problems with this account. The first problem is the ‘inevitability’ of sinning. Here, the defender is forced either to accept a compatibilist analysis of responsibility or provide a libertarian-friendly analysis of ‘inevitability’. The latter option contradicts the Augustinian contention that it is impossible for sinners to lead a life of virtue and holiness. The second problem has to do with the mechanics of the cognitive effects of sin. The cognitive effects of original sin make it very difficult or inevitable for humans to perform meritorious actions and very easy or inevitable for them to commit sinful actions. If the sinner's degree of control over her sinful actions is so low, it seems that she does not deserve divine blame and punishment for failing to commit meritorious actions. Finally, we raised some problems regarding the fate of the non-culpable sinners.
Integration Referendums as Expressions of Constituent Power: Ireland as a Case Study
Authors: Daly Eoin 
Published: January 2024

AbstractReferendums are usually conceptualized as expressing “constituent power” in obvious settings of constitutional foundation and rupture. However, I argue that if constituent power can be understood as “active” and relational within a political order—and not merely present in political foundings—then it is arguably present in “routine” referendums that have a function neither of foundation nor rupture, but rather of integration, and particularly in the sense of identity formation or consolidation.
Fire‐Induced Carbon Loss and Tree Mortality in Siberian Larch Forests
Authors: Webb Elizabeth E. , Alexander Heather D. , Paulson Alison K. , Loranty Michael M. , DeMarco Jennie , Talucci Anna C. , Spektor Valentin , Zimov Nikita , Lichstein Jeremy W. 
Published: January 2024

AbstractClimate change is intensifying the fire regime across Siberia, with the potential to alter carbon combustion and post‐fire carbon re‐accumulation trajectories. Few field‐based estimates of fire severity (e.g., carbon combustion and tree mortality) exist in Siberian larch forests (Larix spp.), which limits our ability to project how an intensified fire regime will affect regional and global climate feedbacks. Here, we present field‐based estimates of fire‐induced tree mortality and carbon loss in eastern Siberian larch forests. Our results suggest that fires in this region result in high tree mortality (means of 83% and 76% at Arctic and subarctic sites, respectively). In both absolute and relative terms, aboveground carbon loss following fire is higher in Siberian larch forests than in North America, but belowground carbon loss is considerably lower. This suggests fundamental differences in wildfire behavior and carbon dynamics between dominant vegetation types across the boreal biome.
Estuarine Exchange Flow in the Salish Sea
Authors: MacCready Parker , Geyer W. Rockwell 
Published: January 2024

AbstractThe Salish Sea is a large, fjordal estuarine system opening onto the northeast Pacific Ocean. It develops a strong estuarine exchange flow that draws in nutrients from the ocean and flushes the system on timescales of several months. It is difficult to apply existing dynamical theories of estuarine circulation there because of the extreme bathymetric complexity. A realistic numerical model of the system was manipulated to have stronger and weaker tides to explore the sensitivity of the exchange flow to tides. This sensitivity was explored over two timescales: annual means and the spring‐neap. Two theories for the estuarine exchange flow are: (a) “gravitational circulation” where exchange is driven by the baroclinic pressure gradient due to along‐channel salinity variation, and (b) “tidal pumping” where tidal advection combined with flow separation forces the exchange. Past observations suggested gravitational circulation was of leading importance in the Salish Sea. We find here that the exchange flow increases with stronger tides, particularly in annual averages, suggesting it is controlled by tidal pumping. However, the landward salt transport due to the exchange flow decreases with stronger tides because greater mixing decreases the salinity difference between incoming and outgoing water. These results may be characteristic of estuarine systems that have rough topography and strong tides.
Propagation Mechanism of Branched Downward Positive Leader Resulting in a Negative Cloud‐To‐Ground Flash
Authors: Ding Z. , Rakov V. A. , Zhu Y. , Kereszy I. , Chen S. , Tran M. D. 
Published: January 2024

AbstractOur basic knowledge of downward positive lightning leaders is incomplete due to their rarity and limited ability of VHF mapping systems to image positive streamers. Here, using high‐speed optical records and wideband electric field and magnetic field derivative signatures, we examine in detail the development of a descending positive leader, which extended intermittently via alternating branching at altitudes of 4.2 to 1.9 km and involved luminosity transients separated by millisecond‐scale quiet intervals. We show that the transients (a) are mostly initiated in previously created but already decayed branches, at a distance of the order of 100 m above the branch lower extremity, (b) extend bidirectionally with negative charge moving up, (c) establish a temporary (1 ms or so) steady‐current connection to the negative part of the overall bidirectional leader tree, and (d) exhibit brightening accompanied by new breakdowns at the positive leader end. One of the transients unexpectedly resulted in a negative cloud‐to‐ground discharge. Both positive and negative ends of the transients extended at speeds of 106–107 m/s, while the overall positive leader extension speed was as low as 103–104 m/s. Wideband electric field signatures of the transients were similar to K‐changes, with their millisecond‐ and microsecond‐scale features being associated with the steady current and new breakdowns, respectively. For transients with both ends visible in our optical records, charge transfers and average currents were estimated to be typically a few hundreds of millicoulombs and some hundreds of amperes, respectively.
Amplified Production and Export of Dissolved Inorganic Carbon During Hot and Wet Subtropical Monsoon
Authors: Wen Hang , Li Si‐Liang , Chen Xi , Qin Caiqing , Li Li 
Published: January 2024

AbstractUnderstanding the origins and processes of riverine dissolved inorganic carbon (DIC) is crucial for predicting the global carbon cycle with projected, more frequent climate extremes yet our knowledge has remained fragmented. Here we ask: How and how much do DIC production and export vary across space (shallow vs. deep, uphill vs. depression) and time (daily, seasonal, and annual)? How do the relative contributions of biogenic (soil respiration) and geogenic (carbonate weathering) sources differ under different temperature and hydrological conditions? We answer these questions using a catchment‐scale reactive transport model constrained by stream flow, stable water isotopes, stream DIC, and carbon isotope data from a headwater karstic catchment in southwest China in a subtropical monsoon climate. Results show climate seasonality regulates the timing of DIC production and export. In hot‐wet seasons, high temperature accelerates soil respiration and carbonate weathering (up to a factor of three) via elevating soil CO2 and carbonate solubility, whereas high discharge enhances export by two orders of magnitude compared to cold‐dry seasons. Carbonate weathering is driven more by soil CO2 than water flow. At the annual scale, 92.9% and 7.1% of DIC was produced in shallow and deep zone, respectively, whereas 64.5% and 35.5% of DIC was exported from shallow and deep zone, respectively. These results highlight the uniqueness of subtropical karst areas as synchronous reactors and transporters of DIC during the hot‐wet monsoon, contrasting the asynchronous production and export in other climate regions. A future hotter and wetter climate with more intensive storms in the region may further intensify DIC production and export, accentuating the potential of subtropical karst regions as global hot spots for carbon cycling.
Cellular zinc metabolism and zinc signaling: from biological functions to diseases and therapeutic targets
Authors: Chen Bonan , Yu Peiyao , Chan Wai Nok , Xie Fuda , Zhang Yigan , Liang Li , Leung Kam Tong , Lo Kwok Wai , Yu Jun , Tse Gary M. K. , Kang Wei , To Ka Fai 
Published: January 2024

AbstractZinc metabolism at the cellular level is critical for many biological processes in the body. A key observation is the disruption of cellular homeostasis, often coinciding with disease progression. As an essential factor in maintaining cellular equilibrium, cellular zinc has been increasingly spotlighted in the context of disease development. Extensive research suggests zinc’s involvement in promoting malignancy and invasion in cancer cells, despite its low tissue concentration. This has led to a growing body of literature investigating zinc’s cellular metabolism, particularly the functions of zinc transporters and storage mechanisms during cancer progression. Zinc transportation is under the control of two major transporter families: SLC30 (ZnT) for the excretion of zinc and SLC39 (ZIP) for the zinc intake. Additionally, the storage of this essential element is predominantly mediated by metallothioneins (MTs). This review consolidates knowledge on the critical functions of cellular zinc signaling and underscores potential molecular pathways linking zinc metabolism to disease progression, with a special focus on cancer. We also compile a summary of clinical trials involving zinc ions. Given the main localization of zinc transporters at the cell membrane, the potential for targeted therapies, including small molecules and monoclonal antibodies, offers promising avenues for future exploration.
Aberrant resting-state co-activation network dynamics in major depressive disorder
Authors: An Ziqi , Tang Kai , Xie Yuanyao , Tong Chuanjun , Liu Jiaming , Tao Quan ,   DIRECT Consortium, Yan Chao-Gan , Chen Xiao , Cao Li-Ping , Chen Wei , Cheng Yu-Qi , Fang Yi-Ru , Gong Qi-Yong , Guo Wen-Bin , Kuang Li , Li Bao-Juan , Li Tao , Liu Yan-Song , Liu Zhe-Ning , Lu Jian-Ping , Luo Qing-Hua , Meng Hua-Qing , Peng Dai-Hui , Qiu Jiang , Shen Yue-Di , Si Tian-Mei , Tang Yan-Qing , Wang Chuan-Yue , Wang Fei , Wang Hua-Ning , Wang Kai , Wang Xiang , Wang Ying , Wu Xiao-Ping , Xie Chun-Ming , Xie Guang-Rong , Xie Peng , Xu Xiu-Feng , Yang Hong , Yang Jian , Yao Shu-Qiao , Yu Yong-Qiang , Yuan Yong-Gui , Zhang Ke-Rang , Zhang Wei , Zhang Zhi-Jun , Zhu Jun-Juan , Zuo Xi-Nian , Zhao Jing-Ping , Zang Yu-Feng , Feng Yanqiu 
Published: January 2024

AbstractMajor depressive disorder (MDD) is a globally prevalent and highly disabling disease characterized by dysfunction of large-scale brain networks. Previous studies have found that static functional connectivity is not sufficient to reflect the complicated and time-varying properties of the brain. The underlying dynamic interactions between brain functional networks of MDD remain largely unknown, and it is also unclear whether neuroimaging-based dynamic properties are sufficiently robust to discriminate individuals with MDD from healthy controls since the diagnosis of MDD mainly depends on symptom-based criteria evaluated by clinical observation. Resting-state functional magnetic resonance imaging (fMRI) data of 221 MDD patients and 215 healthy controls were shared by REST-meta-MDD consortium. We investigated the spatial-temporal dynamics of MDD using co-activation pattern analysis and made individual diagnoses using support vector machine (SVM). We found that MDD patients exhibited aberrant dynamic properties (such as dwell time, occurrence rate, transition probability, and entropy of Markov trajectories) in some transient networks including subcortical network (SCN), activated default mode network (DMN), de-activated SCN-cerebellum network, a joint network, activated attention network (ATN), and de-activated DMN-ATN, where some dynamic properties were indicative of depressive symptoms. The trajectories of other networks to deactivated DMN-ATN were more accessible in MDD patients. Subgroup analyses also showed subtle dynamic changes in first-episode drug-naïve (FEDN) MDD patients. Finally, SVM achieved preferable accuracies of 84.69%, 76.77%, and 88.10% in discriminating patients with MDD, FEDN MDD, and recurrent MDD from healthy controls with their dynamic metrics. Our findings reveal that MDD is characterized by aberrant dynamic fluctuations of brain network and the feasibility of discriminating MDD patients using dynamic properties, which provide novel insights into the neural mechanism of MDD.
BCL-XL regulates the timing of mitotic apoptosis independently of BCL2 and MCL1 compensation
Authors: Yu Chun Yin , Yeung Tsz Kwan , Fu Wai Kuen , Poon Randy Y. C. 
Published: January 2024

AbstractMitotic catastrophe induced by prolonged mitotic arrest is a major anticancer strategy. Although antiapoptotic BCL2-like proteins, including BCL-XL, are known to regulate apoptosis during mitotic arrest, adaptive changes in their expression can complicate loss-of-function studies. Our studies revealed compensatory alterations in the expression of BCL2 and MCL1 when BCL-XL is either downregulated or overexpressed. To circumvent their reciprocal regulation, we utilized a degron-mediated system to acutely silence BCL-XL just before mitosis. Our results show that in epithelial cell lines including HeLa and RPE1, BCL-XL and BCL2 acted collaboratively to suppress apoptosis during both unperturbed cell cycle and mitotic arrest. By tagging BCL-XL and BCL2 with a common epitope, we estimated that BCL-XL was less abundant than BCL2 in the cell. Nonetheless, BCL-XL played a more prominent antiapoptotic function than BCL2 during interphase and mitotic arrest. Loss of BCL-XL led to mitotic cell death primarily through a BAX-dependent process. Furthermore, silencing of BCL-XL led to the stabilization of MCL1, which played a significant role in buffering apoptosis during mitotic arrest. Nevertheless, even in a MCL1-deficient background, depletion of BCL-XL accelerated mitotic apoptosis. These findings underscore the pivotal involvement of BCL-XL in controlling timely apoptosis during mitotic arrest, despite adaptive changes in the expression of other BCL2-like proteins.
Mapping of individual sensory nerve axons from digits to spinal cord with the transparent embedding solvent system
Authors: Yi Yating , Li Youqi , Zhang Shiwen , Men Yi , Wang Yuhong , Jing Dian , Ding Jiayi , Zhu Qingjie , Chen Zexi , Chen Xingjun , Li Jun-Liszt , Wang Yilong , Wang Jun , Peng Hanchuan , Zhang Li , Luo Wenjing , Feng Jian Q. , He Yongwen , Ge Woo-Ping , Zhao Hu 
Published: January 2024

AbstractAchieving uniform optical resolution for a large tissue sample is a major challenge for deep imaging. For conventional tissue clearing methods, loss of resolution and quality in deep regions is inevitable due to limited transparency. Here we describe the Transparent Embedding Solvent System (TESOS) method, which combines tissue clearing, transparent embedding, sectioning and block-face imaging. We used TESOS to acquire volumetric images of uniform resolution for an adult mouse whole-body sample. The TESOS method is highly versatile and can be combined with different microscopy systems to achieve uniformly high resolution. With a light sheet microscope, we imaged the whole body of an adult mouse, including skin, at a uniform 0.8 × 0.8 × 3.5 μm3 voxel resolution within 120 h. With a confocal microscope and a 40×/1.3 numerical aperture objective, we achieved a uniform sub-micron resolution in the whole sample to reveal a complete projection of individual nerve axons within the central or peripheral nervous system. Furthermore, TESOS allowed the first mesoscale connectome mapping of individual sensory neuron axons spanning 5 cm from adult mouse digits to the spinal cord at a uniform sub-micron resolution.
Learning low-rank latent mesoscale structures in networks
Authors: Lyu Hanbaek , Kureh Yacoub H. , Vendrow Joshua , Porter Mason A. 
Published: January 2024

AbstractResearchers in many fields use networks to represent interactions between entities in complex systems. To study the large-scale behavior of complex systems, it is useful to examine mesoscale structures in networks as building blocks that influence such behavior. In this paper, we present an approach to describe low-rank mesoscale structures in networks. We find that many real-world networks possess a small set of latent motifs that effectively approximate most subgraphs at a fixed mesoscale. Such low-rank mesoscale structures allow one to reconstruct networks by approximating subgraphs of a network using combinations of latent motifs. Employing subgraph sampling and nonnegative matrix factorization enables the discovery of these latent motifs. The ability to encode and reconstruct networks using a small set of latent motifs has many applications in network analysis, including network comparison, network denoising, and edge inference.
African bushpigs exhibit porous species boundaries and appeared in Madagascar concurrently with human arrival
Authors: Balboa Renzo F. , Bertola Laura D. , Brüniche-Olsen Anna , Rasmussen Malthe Sebro , Liu Xiaodong , Besnard Guillaume , Salmona Jordi , Santander Cindy G. , He Shixu , Zinner Dietmar , Pedrono Miguel , Muwanika Vincent , Masembe Charles , Schubert Mikkel , Kuja Josiah , Quinn Liam , Garcia-Erill Genís , Stæger Frederik Filip , Rakotoarivony Rianja , Henrique Margarida , Lin Long , Wang Xi , Heaton Michael P. , Smith Timothy P. L. , Hanghøj Kristian , Sinding Mikkel-Holger S. , Atickem Anagaw , Chikhi Lounès , Roos Christian , Gaubert Philippe , Siegismund Hans R. , Moltke Ida , Albrechtsen Anders , Heller Rasmus 
Published: January 2024

AbstractSeveral African mammals exhibit a phylogeographic pattern where closely related taxa are split between West/Central and East/Southern Africa, but their evolutionary relationships and histories remain controversial. Bushpigs (Potamochoerus larvatus) and red river hogs (P. porcus) are recognised as separate species due to morphological distinctions, a perceived lack of interbreeding at contact, and putatively old divergence times, but historically, they were considered conspecific. Moreover, the presence of Malagasy bushpigs as the sole large terrestrial mammal shared with the African mainland raises intriguing questions about its origin and arrival in Madagascar. Analyses of 67 whole genomes revealed a genetic continuum between the two species, with putative signatures of historical gene flow, variable FST values, and a recent divergence time (<500,000 years). Thus, our study challenges key arguments for splitting Potamochoerus into two species and suggests their speciation might be incomplete. Our findings also indicate that Malagasy bushpigs diverged from southern African populations and underwent a limited bottleneck 1000-5000 years ago, concurrent with human arrival in Madagascar. These results shed light on the evolutionary history of an iconic and widespread African mammal and provide insight into the longstanding biogeographic puzzle surrounding the bushpig’s presence in Madagascar.