bluuebunny/crossref_metadata_2025_split huggingface dataset:
Treatment mechanism of the WHO caregiver skills training intervention for autism delivered in community settings
Authors: Settanni Michele , Suma Katharine , Adamson Lauren B. , McConachie Helen , Servili Chiara , Salomone Erica 
Published: December 2023

AbstractThis study examined the mechanism of effect of the WHO Caregiver Skills Training (CST) through secondary analysis of a pilot RCT conducted in community settings. Participants were 86 caregivers (77% mothers) of children with ASD (78% male, mean age: 44.8 months) randomized to CST (n = 43) or treatment as usual (n = 43). The primary outcomes, measured at baseline (t1), immediately post‐intervention (t2), and 3 months post‐intervention (t3), were derived from the coding of caregiver‐child free play interactions with the Brief Observation of Social‐Communication Change (BOSCC) and the Joint Engagement Rating Inventory scale (JERI). At t3 positive treatment main effects had been observed for caregiver skills supportive of the interaction and for flow of the interaction (JERI), albeit only non‐significant changes in the expected direction for child outcomes: autism phenotypic behaviors (BOSCC), joint engagement and availability to interact (JERI). This study tested the theory of change of CST, hypothesizing that the intervention would lead to an improvement on all child and dyad outcomes through an increase in the caregiver skills supportive of the interaction. Serial mediation analyses revealed that the effect of the intervention was significantly influenced by change in caregiver skills. Participation in the intervention led to notable increases in caregiver skills at t2 and t3, which subsequently contributed to improvements at t3 in flow of the interaction, autism phenotypic behavior, joint engagement, and availability to interact. We confirmed our a priori hypothesis showing that change in caregiver skills significantly mediated the effect of treatment on the dyad primary outcome, as well as on the other child outcomes that had shown non‐significant changes in the expected direction. Implications for intervention design and policy making in the context of public health services are discussed.
On the Influence of Li3InCl6−PEDOT:PSS Hybrids in Solid‐State Batteries Prepared via an Aqueous One‐Pot Approach
Authors: Nazmutdinova Elina , Rosenbach Carolin , Schmidt Christina , Sarawutankul Sangchai , Neuhaus Kerstin , Gröschel André , Vargas‐Barbosa Nella M. 
Published: December 2023

AbstractSolid‐state batteries (SSBs) utilizing halide solid electrolytes (SE) have garnered attention due to their enhanced stability when paired with oxide‐based cathode active materials. However, the dynamic interparticle contact during cycling in SSBs poses challenges to their stability and performance. To mitigate this problem, in this study, we present a one‐pot, aqueous synthesis of composites that integrate ion conductivity, electron conductivity, and mechanical stability into a single material. The developed composites consist of a halide SE, lithium indium chloride (Li3InCl6), and a conductive polymer (CP), poly(3,4‐ethylendioxythiophene)/poly(styrene sulfonate) (PEDOT:PSS). The successful synthesis was verified using spectroscopic, thermal, scattering, and microscopy methods, with Kelvin Probe Force Microscopy (KPFM) demonstrating the distribution of PEDOT:PSS at the grain boundaries between Li3InCl6 particles. Upon incorporating our composite material with lithium nickel manganese cobalt oxide (NMC) cathode active material (CAM) as catholyte, an increase in the partial electronic transport was observed with increasing CP content. A direct correlation between the partial electronic transport of the catholytes and the initial discharge capacities was demonstrated. This study lays the groundwork for the preparation of multi‐functional catholytes under more sustainable conditions, without the need for organic solvents, extremely high temperatures, or special environments.
Exploring sustainable development goals adoption in supply chain management: A typology of coexisting institutional logics
Authors: Carmagnac Liliane , Silva Minelle E. , Fritz Morgane M. C. 
Published: December 2023

AbstractDespite growing interest in the 17 United Nations (UN) sustainable development goals (SDGs), companies still struggle with how to implement them as part of their sustainability policies. Hence, we explore how the SDGs are adopted in supply chain management (SCM) using institutional logic as a theoretical lens. Based on a case study, we analyse 10 interviews conducted with managers and suppliers of a multinational cosmetics company recognised for its sustainability engagement. Our findings show that while the strategic level embraces the SDG framework, supply management processes are exclusively evident at the operational level. This becomes even more salient in the analysis of sustainability and commercial coexisting logics. Although sustainability logic concerns compliance with sustainability‐related regulations and external pressures, commercial logic demonstrates the effective engagement of strategic decisions in favor of profitability. Our results reveal nuances in the existing gap between the SDGs and SCM, illustrated through a typology of coexisting logics at the strategic and operational levels, adding value to the SCM literature. This paper questions the feasibility of implementing the UN SDGs along a supply chain, which opens the door for future research and new practical insights relevant to companies' daily operations.
Differential sensitivity to hypoxia enables shape‐based classification of sickle cell disease and trait blood samples at point of care
Authors: D'Costa Claudy , Sharma Oshin , Manna Riddha , Singh Minakshi , Singh Samrat , Singh Srushti , Mahto Anish , Govil Pratiksha , Satti Sampath , Mehendale Ninad , Italia Yazdi , Paul Debjani 
Published: December 2023

AbstractRed blood cells (RBCs) become sickle‐shaped and stiff under hypoxia as a consequence of hemoglobin (Hb) polymerization in sickle cell anemia. Distinguishing between sickle cell disease and trait is crucial during the diagnosis of sickle cell disease. While genetic analysis or high‐performance liquid chromatography (HPLC) can accurately differentiate between these two genotypes, these tests are unsuitable for field use. Here, we report a novel microscopy‐based diagnostic test called ShapeDx™ to distinguish between disease and trait blood in less than 1 h. This is achieved by mixing an unknown blood sample with low and high concentrations of a chemical oxygen scavenger and thereby subjecting the blood to slow and fast hypoxia, respectively. The different rates of Hb polymerization resulting from slow and fast hypoxia lead to two distinct RBC shape distributions in the same blood sample, which allows us to identify it as healthy, trait, or disease. The controlled hypoxic environment necessary for differential Hb polymerization is generated using an imaging microchamber, which also reduces the sickling time of trait blood from several hours to just 30 min. In a single‐blinded proof‐of‐concept study conducted on a small cohort of clinical samples, the results of the ShapeDx™ test were 100% concordant with HPLC results. Additionally, our field studies have demonstrated that ShapeDx™ is the first reported microscopy test capable of distinguishing between sickle cell disease and trait samples in resource‐limited settings with the same accuracy as a gold standard test.
Consumer behavior in the metaverse
Authors: Kaur Jaspreet , Mogaji Emmanuel , Paliwal Manisha , Jha Suchita , Agarwal Shailja , Mogaji Stephen Alaba 
Published: December 2023

AbstractThe rising interest in the marketing potential of the metaverse and its influence on consumer behavior is undeniable. Experts in the field have identified gaps in understanding consumer behavior in the metaverse and have highlighted the need of further research in the domain. This study addresses this void by focusing on Gen Z and their interactions within the metaverse. Gathering qualitative data through semi‐structured interviews with 63 participants, the study employs a deductive thematic analysis, using the Engel‐Kollat‐Blackwell (EKB) model as its theoretical framework. The findings align with the stages of the EKB model– awareness, information search, engagement, and post‐engagement evaluation. We find that despite facing initial challenges, participants display eagerness to access the metaverse and actively seek engagement opportunities, even encouraging others to join. This research provides empirical insights into challenges and opportunities that exist for consumers and brands within the metaverse. Further, it also enhances our understanding of immersive time in the metaverse and elucidates consumer engagement with digital technologies. Finally, the study also offers practical implications for managers, tech developers, and policymakers looking to enhance consumer interest and involvement in the metaverse.
Rational Design of Hydroxylated Thiazole Orange Photocages for Green Light‐Triggered DNA Recombination
Authors: Hashimoto Ryu , Minoshima Masafumi , Kikuchi Kazuya 
Published: December 2023

AbstractThe precise control of DNA recombination enables the cell‐ or time‐dependent regulation of gene expression in studies of gene function. Caged estrogen receptor ligands combined with a Cre‐ERT2/loxP system are useful tools for light‐triggered DNA recombination. However, the photolysis of most caged compounds requires ultraviolet or blue light, which is toxic and displays low tissue penetration. Although a cyanine‐based photo‐responsive protecting group (PPG) can release estrogen receptor ligands with longer‐wavelength light, its low photolytic efficiency requires long illumination times. We developed a caged estrogen receptor ligand with improved green light‐responsive PPGs. The rational modification of Hydroxylated Thiazole Orange (HTO) photocages using electron‐donating groups (EDGs), such as dimethoxy (DiMeO)‐substituted HTO, resulted in high photolytic efficiency (up to ϵΦ ≈320 M−1 cm−1). Theoretical calculations demonstrated that the enhanced photolytic efficiencies were derived from the increased intramolecular charge transfer by EDGs upon excitation. The efficient uncaging of estrogen receptor ligands enabled the control of gene recombination in a ligand‐dependent Cre‐ERT2/loxP system in live cells.
Dementia and epilepsy following COVID‐19 infection in a 25‐year‐old female: A case report
Authors: Ahmed Farea , Taimuri Muskan Asim , Ikram Areeba , Sumbal Anusha , Ali Sajjad , Anan Mahfuza 
Published: December 2023

Key Clinical MessageSignificant atypical neurologic signs have also been recorded in COVID‐19 individuals, along with a variety of other extra‐pulmonary indications. The COVID‐19 virus is neuro‐invasive and holds significant potential to produce some unconventional neurologic manifestations
Primary abdominal cocoon syndrome manifesting with Chilaiditi syndrome and intestinal obstruction: A case report
Authors: Tajaddini Ali , Fallahi Mohammadmehdi , Haghshenas Hoda , Nourmohammadi Soheila‐sadat , Ghahramani Leila , Shahriarirad Reza 
Published: December 2023

Key Clinical MessageAbdominal cocoon syndrome and Chilaiditi syndrome are rare etiologies of bowel obstruction which have to be considered in patients with obstructive symptoms. Patients can profit from surgical management rather than non‐surgical approach.AbstractEncapsulating peritoneal sclerosis or abdominal cocoon syndrome (ACS) is an uncommon cause of intestinal obstructions associated with encapsulation of the small bowel by a fibro collagenous sac. Clinical presentations of ACS are unspecific and most patients are diagnosed intraoperatively. Moreover, Chilaiditi syndrome is another rare cause of bowel obstruction defined by interposition of colon and liver. There is no reported relation between these two conditions and surgical intervention is the suggested approach for severe bowel obstruction following them individually. We present a case with both conditions and describe our approach. A 47‐year‐old male presented with complaints of colic abdominal pain and distention, nausea and several attacks of bilious and nonbilious vomiting, anorexia, and constipation in the last 10 days before his admission. Laboratory data were normal and abdominal X‐ray showed large dilation at the distal part of the bowel without air fluid level. The patient underwent explorative laparotomy and a mass‐like lesion containing necrotic bowel and a whitish spleen accompanied by a complete anterior‐rotated liver was found. The encapsulated bowel and the spleen were resected followed by the complete resolution of symptoms in the patient. The intestinal obstruction caused by ACS is mostly approached by surgery to prevent the fatal sequela of this condition.
Unusual presentation and histopathology of bilateral nasal polypi; cavernous hemangioma (right) and inverted papilloma (left)
Authors: Hasan Abdulkarim , Mairaj Muhammad Yousaf , Elbadawy Ahmed , Zayed Sameh , Alghamdi Abdulkhaliq Saeed , Alrashdi Saeed Awad , Nafie Khalid 
Published: December 2023

AbstractHemangiomas are common lesions in medical practice, but those arising in the nasal cavity and/or paranasal sinuses are rare. Inverted papilloma is a rare benign tumor with a high incidence rate in both the nasal cavity and sinuses. The presence of both lesions in the same patient is even rarer. Here we present a case of a male patient with an unusual presentation and dual pathologies of cavernous hemangioma and inverted papilloma of the sinonasal tract that underwent endoscopic surgery and showed no recurrence of disease after a 2‐year follow‐up. The association of nasal cavernous hemangioma at one side and inverted papilloma at the other side is a very rare occasion that requires further studies and histopathology is the only diagnostic tool.
Malignant involvement of the iliopsoas muscle associated with non‐small cell lung cancer: Two case reports
Authors: Kodama Ken , Momozane Toru , Shigetsu Kaichi , Takehara Hiroshi , Toyofuku Takamasa , Nishiyama Kinji , Koh Genju , Uryu Kiyoaki 
Published: December 2023

Key Clinical MessageUnder the current progression of molecular targeting or immune therapy, early detection and radiation therapy of iliopsoas metastasis will not only improve performance status but also enable the continuation of effective systemic cancer treatment.
Crohn's disease: An enigmatic variant with gastritis and ileal obstruction
Authors: Amo‐Tachie Samuel , Ocansey Fredrick Kojo , Yeboah Abena Durowaa 
Published: December 2023

Key Clinical MessageThere are multiple atypical manifestations of Crohn's disease, which sometimes delay diagnosis or even more often result in complete misdiagnosis, especially in poorly equipped facilities. This is the case of an elderly woman with Crohn's disease who presented with gastritis and bowel obstruction. She had hitherto been wrongly managed for peptic ulcer disease and functional constipation based mainly on her symptoms. Her diagnosis was made only after years of failed symptomatic management. This case aims to highlight the uncommon and easily misdiagnosed gastroduodenal presentation of Crohn's disease, as well as clinical clues to correctly diagnosing the condition.
Stabilizing the unstable: Tuberculosis of the odontoid process with atlanto‐occipital instability—Case report and review of literature
Authors: Duvuru Shyam , Sanker Vivek , Dave Tirth , Agarwal Pratik , Syed Naureen 
Published: December 2023

Key Clinical MessageTuberculosis (TB) of the odontoid process is a rare but potentially, a debilitating condition. Surgical intervention, in the form of stabilizing the spine and decompressing the spinal cord, offers a tailored approach to managing this condition effectively and improving prognosis.AbstractOdontoid process tuberculosis (TB) is a rare condition that can cause spinal instability and neurological complications. Diagnosis of odontoid process TB is difficult and requires a combination of clinical, radiographic, and histopathological examinations. This report describes the treatment of a 46‐year‐old female with quadriparesis and intermittent fever. Radiological findings showed TB of the odontoid process with atlanto‐axial dislocation causing compressive myelopathy. She underwent C1–C3 decompressive laminectomy and stabilization from C1 to C5. GeneXpert for TB was positive and she was started on anti‐tuberculous medications. She regained power gradually and at 1 year follow‐up she was ambulant without any support. The C1–C5 lateral mass screw and C1–C3 decompressive laminectomy approach, as highlighted in this case, offers an effective solution, enhancing patient quality of life, and preventing disease progression.
Unilateral orbital schwannoma arising from the supraorbital nerve: Report of a rare case
Authors: Uppal Shikhil , Saggar Vineet , Scalia Gianluca , Umana Giuseppe Emmanuele , Sharma Manisha , Chaurasia Bipin 
Published: December 2023

Key Clinical MessageSchwannomas are rare tumors in the orbit, typically originating from various nerves and presenting diagnostic challenges. We present a unique case of a unilateral orbital schwannoma arising from the supraorbital nerve. A 55‐year‐old female presented with a painless, slowly growing mass in the right superior orbit, causing proptosis. Visual acuity remained unimpaired, and clinical examination revealed a well‐defined mass in the superior orbit. A provisional diagnosis of an orbital dermoid or cyst was made, leading to excision biopsy. The histopathological examination confirmed a diagnosis of benign schwannoma. Schwannomas in the orbit, particularly those arising from the supraorbital nerve, are uncommon and often challenging to diagnose. Early surgical intervention is crucial to prevent complications associated with tumor growth. This case underscores the need to consider schwannomas as a differential diagnosis for slow‐growing orbital masses in adults and emphasizes the importance of timely management to prevent vision‐threatening complications.
Monitoring the outcomes of non‐pharmacological treatments for cognitive impairment using magnetoencephalography: A case series
Authors: Hirata Yoko , Hoshi Hideyuki , Kobayashi Momoko , Shibamiya Keita , Fukasawa Keisuke , Ichikawa Sayuri , Shigihara Yoshihito 
Published: December 2023

Key Clinical MessageCognitive impairment associated dementia is treatable non‐pharmacologically. Monitoring tools are important to provide proper treatment. The present study showed that the resting‐state brain activity measured using magnetoencephalography reflects their outcomes and captures clinical impressions better than neuropsychological assessments, which have inherent limitations such as the practice effect.AbstractMild cognitive impairment (MCI) is a prodromal phase of dementia caused by brain diseases. Non‐pharmacological treatments are sometimes effective in improving patient's cognition and quality of life. To provide better treatments, monitoring the treatment outcomes, which is done using neuropsychological assessments, is important. However, these assessments have inherent limitations, such as practice effects. Therefore, complementary assessments are anticipated. Magnetoencephalography (MEG) is a neuroimaging technique that is sensitive to changes in brain activity associated with cognitive impairment. It represents the state of brain activity in terms of MEG spectral parameters associated with neuropsychological assessment scores. MEG spectral parameters could reasonably be used to monitor treatment outcomes without the aforementioned limitations. However, few published longitudinal reports have assessed MEG spectral parameters during the non‐pharmacological treatment period for cognitive impairment associated with dementia. In this study, we retrospectively examined the clinical records of two patients with MCI. Changes in neuropsychological assessment scores and MEG spectral parameters were qualitatively evaluated along with the patients' conditions, as described in the medical records during non‐pharmacological treatments provided for more than 2 years. The changes in neuropsychological assessment scores and MEG spectral parameters showed comparable trends, with some discrepancies. Changes in MEG spectral parameters were more consistent with the subjective reports from caregivers and medical staff in the medical records. Our results suggest that MEG is a promising tool for monitoring patient conditions during treatment.
Research progress of Co and Mn‐based catalysts for the oxidation of 5‐hydroxymethylfurfural
Authors: Tang Yongqi , Lv Wei , Wang Yao , Chen Hong , Li Yongdan , Wang Can , Xu Guifeng 
Published: December 2023

AbstractBiomass is a renewable energy source abundantly available in nature. Their degradation by chemical or biological means produces various transition compounds. These transition compounds can be further transformed into valuable chemicals and biofuels that exhibit a wide range of applications and benefits. Recently, there has been a significant focus on this research area. Among the transition compounds, 5‐hydroxymethylfurfural (HMF), derived from the degradation of hexose, is an important biomass‐based platform compound that has hydroxymethyl and aldehyde functional groups in its molecular structure. This study reviews the recent progress in the transition metal‐catalysed conversion of HMF using Co and Mn to generate high‐value‐added downstream products. Furthermore, the active components, the carbon supporter, the reaction mechanism, the oxidants and the reaction conditions of the catalysts are discussed in detail. The oxidation of HMF deserves further research as an important and complete value‐added process for generating biomass‐based valuable chemicals.
Transition Metal Catalysts for the Glycerol Reduction: Recent Advances
Authors: Coccia Francesca , d'Alessandro Nicola , Mascitti Andrea , Colacino Evelina , Tonucci Lucia 
Published: December 2023

AbstractGlycerol (GL) represents a widespread agro‐industrial waste. Its valorization is pivotal for a sustainable society because GL is a renewable compound deriving from biomass, but it has a high oxygen to carbon ratio, compared with feedstock used in the energy and chemistry sectors. Oxygen‐poor derivatives are easily and immediately transferable to the industry, avoiding a deep and pressing modification of the plants. From this perspective, keeping the carbon content but with an oxygen content reduction, we could effectively obtain the enhancement of the recovery and the use of GL converting it into attractive industrial building‐blocks. In this Review, we present and discuss the up‐to‐date results about the chemical reduction of GL into products with 3 carbon and 0, 1, or 2 oxygen atoms. The focus is on the transition metal (TM) catalysts that have made the hydrogenation reactions of GL possible, partitioning the metals into early and late, based on their position in the periodic table. This discussion will contribute to select and develop new catalysts aimed at the improvement of the yield and of the selectivity in the hydrogenation reactions of GL.