bluuebunny/crossref_metadata_2025_split huggingface dataset:
Towards a collaborative approach to the systematics of Ipomoea: A response to the “Rebuttal to (2786) Proposal to change the conserved type of Ipomoea, nom. cons. (Convolvulaceae)”
Authors: Eserman Lauren A. , Buril Maria Teresa , Chatrou Lars W. , Clay Keith , Desquilbet Thibaut E. , Ferreira Priscila P.A. , Grande Allende José R. , Huerta‐Ramos Guillermo , Kojima Roberta K. , Miller Richard E. , More Sushant , Moreira André L.C. , Pastore Mayara , Petrongari Fernanda S. , Pisuttimarn Ponprom , Pornpongrungrueng Pimwadee , Rifkin Joanna , Shimpale Vinod B. , Sosef Marc S.M. , Stinchcombe John R. , Simões Ana Rita G. 
Published: October 2023

AbstractA proposal to change the conserved type of Ipomoea was published in December 2020, and recommended by the Nomenclature Committee in 2023. This was done in the light of the possible negative consequences for a name change in the crop sweetpotato, which risk our proposal would significantly minimize. Recently, Muñoz‐Rodríguez & al. have published a rebuttal to this proposal, which we respond to here. The objections raised by these authors focus as much on the expertise and credibility of our group of authors as on the merits of our arguments. In this “rebuttal to the rebuttal”, we respond to the scientific questions raised, highlight demonstrated misinterpretation of the specialised literature relevant to this discussion and counter the assertion that a reclassification of Ipomoeeae is impossible given existing evidence. While the currently recognised genera of Ipomoeeae are not all monophyletic, the proposal to change the conserved type of Ipomoea is a necessary step that will allow exploring an improved classification for the tribe Ipomoeeae, either in the form of a better recircumscription of the genera or an efficient infrageneric classification for Ipomoea. Previously published literature has not advocated for the integration of all genera into a single genus, as Muñoz‐Rodríguez and co‐authors have incorrectly suggested, and instead have recommended a reanalysis of the high morphological diversity of the group in the context of expanded phylogenetic studies, with the possible maintenance of some of the existing genera. We believe that, in a concerted collaborative approach and with the contribution of experts from different regions and scientific backgrounds, an improved classification of Ipomoeeae that integrates the principles of monophyly and diagnosability may soon be achieved, and until when some uncertainty may need to be accommodated, with the added reassurance that, regardless of the direction of future systematic rearrangements, the stability of the scientific name of sweetpotato would be preserved.
Non‐invasive in‐utero quantification of vascular reactivity in human placenta
Authors: Rajagopalan V. , Truong V. , Wang S. , Lopez J. , Rosas V. , Borzage M. , Votava‐Smith J. K. , Ponrartana S. , Panigrahy A. , Detterich J. , Wood J. 
Published: October 2023

ABSTRACTObjectivePlacental vascular reactivity (PlVR) indicates the ability of the placental vasculature to match blood supply to fetal demand. Many pregnancy disorders alter the characteristics of PlVR, resulting in suboptimal oxygen delivery, although current understanding is limited by the lack of non‐invasive, repeatable methods to measure PlVR in utero. Our objective was to quantify PlVR by measuring the placental response to transient changes in maternal carbon dioxide (CO2) using blood‐oxygen‐level‐dependent (BOLD) magnetic resonance imaging (MRI). We hypothesized that PlVR will increase with gestational age to meet the changing demands of a growing fetus, and that PlVR will be driven by a maternal response to changes in CO2 concentration.MethodsThis was a cross‐sectional study of 35 women with a healthy singleton pregnancy, of whom 31 were included in the analysis. The median gestational age was 32.6 (range, 22.6–38.4) weeks. Pregnant women were instructed to follow audiovisual breathing cues during a MRI scan. Maternal end‐tidal CO2 (EtCO2) was measured concurrently with resting placental BOLD MRI for a total of 7–8 min. Preprocessing of magnetic resonance images consisted of manual delineation of placental anatomy and motion correction. In each placental voxel, vascular reactivity was computed using a coherence‐weighted general linear model between MRI signal and EtCO2 stimulus. Global PlVR was computed as the mean of voxel‐wise PlVR values across the placenta.ResultsPlVR, quantified by the placental response to induced, transient changes in maternal CO2, was consistently measured in utero using BOLD MRI. PlVR increased non‐linearly with advancing gestational age (P < 0.001) and was higher on the fetal side of the placenta. PlVR was associated positively with fetal brain volume after accounting for gestational age. PlVR did not show any significant associations with maternal characteristics.ConclusionsWe present, for the first time, a non‐invasive paradigm to quantify PlVR in ongoing human pregnancies without the use of exogenous gases or contrast agents. Our findings suggest that PlVR is driven by a fetal response to changes in maternal CO2. Ease of translation to the clinical setting makes PlVR a promising biomarker for the identification and management of high‐risk pregnancies. © 2023 The Authors. Ultrasound in Obstetrics & Gynecology published by John Wiley & Sons Ltd on behalf of International Society of Ultrasound in Obstetrics and Gynecology.
Analysis and Quality Control of WHO- and UNEP-Coordinated Human Milk Studies 2000–2019: Polybrominated Diphenyl Ethers, Hexabromocyclododecanes, Chlorinated Paraffins and Polychlorinated Naphthalenes
Authors: Schächtele Alexander , Hardebusch Björn , Krätschmer Kerstin , Tschiggfrei Karin , Zwickel Theresa , Malisch Rainer 
Published: October 2023

AbstractFour different analytical methods were used for the determination of (1) polybrominated diphenyl ethers (PBDE), (2) hexabromocyclododecanes (HBCDD), (3) chlorinated paraffins (CP) and (4) polychlorinated naphthalenes (PCN) in human milk samples of the WHO/UNEP-coordinated exposure studies. As a laboratory accredited according to EN ISO/IEC 17025, a comprehensive quality control program was applied to assure the reliability of results. This included procedural blanks, the use of numerous quality control samples as in-house reference materials and the participation in proficiency tests (PTs). Trueness was estimated from the PT samples using the assigned values.The mean absolute deviation of the sum parameters ∑PBDE6 and ∑PBDE7 from the assigned values of 53 PT samples analysed between 2006 and 2021 was 12% and 14%, respectively.For α-HBCDD as the most abundant diastereomer and the sum of α-, β- and γ-HBCDD, deviations of the reported value from the assigned value of the proficiency tests (31 samples, analysed between 2007 and 2021) were in most cases below 40% over a large concentration range, e.g., for α-HBCDD, between 0.0084 and 19 ng/g fw. For concentrations above 0.5 ng/g lipid, the deviation was in the range of approximately 0–30%.For short-chain and medium-chain CP (SCCP and MCCP) all z-scores achieved in interlaboratory comparisons during 2017–2020 were within ±2 z and therefore satisfactory (13 PT samples were analysed for ΣCP, ΣSCCP and ΣMCCP using the GC-ECNI-Orbitrap-HRMS method, eight results achieved for ΣCP using the GC-EI-MS/MS method).Due to the lack of available proficiency tests for PCN at the time of measuring the human milk samples of the 2016–2019 period, an external validation for control of the trueness was performed through an interlaboratory comparison with an independent laboratory. The deviation of the ΣPCN13 in five test samples between the external laboratory and CVUA Freiburg was in the range from 3 to 20%. At a later stage (in 2021), the laboratory participated successfully in the first interlaboratory comparison study on PCN congeners in cod liver oil. The z-scores for seven congeners and two sum parameters were within ±2 z and therefore satisfactory. Also, the results for other of the altogether 26 PCN congeners were in accordance with the median values reported by all participants.As a result, the determination of PBDE, HBCDD, CP and PCN in human milk samples of the WHO/UNEP-coordinated exposure studies followed the strict rules of the accreditation system and the general criteria for the operation of testing laboratories as laid down in EN ISO/IEC 17025.
Design for manufacturing of a spur gears profile modification based on the static transmission error for improving the dynamic behavior
Authors: Abruzzo Michele , Beghini Marco , Romoli Luca , Santus Ciro 
Published: October 2023

AbstractThis study presents a novel iterative algorithm for obtaining an improved profile modification for spur gears based on minimizing the peak-to-peak static transmission error. Two improved profile modifications, obtained with different initial constraints applied to the tooth profile, were calculated and characterized. The static behavior of the gears was analyzed using a finite element model, by which the modifications were compared considering the maximum contact pressure and peak-to-peak static transmission error. The dynamic behavior of the gears was analyzed using a lumped parameter model. The dynamic overload and the dynamic transmission error were evaluated under several working regimes. The grinding wheel profiles used to realize the proposed profile modifications and the total volume of material removed were calculated using a CAD model. The results showed that the proposed modifications lead to a significant improvement in the static and dynamic behavior of the transmission by reducing both the maximum dynamic overload and meshing noise. The profiles of the grinding wheel were found to be accurately represented by polynomial functions, thus a feasible manufacturing process can be obtained. The total volume of material removed was lower than that produced by commonly adopted profile modifications, thus reducing material waste and increasing the productivity of the manufacturing process compared to standard profile modifications.
The first extensive study of an Imperial Roman Garden in the city of Rome: the Horti Lamiani
Authors: Masi Alessia , Vignola Cristiano , Lazzara Alessandro , Moricca Claudia , Serlorenzi Mirella , Ferrandes Antonio F. 
Published: October 2023

AbstractThis paper presents the first systematic results of integrated plant macrofossil and pollen analyses from the Horti Lamiani (1st-3rd century ce), an aristocratic residence with a luxury garden which was established on the Esquilino (Esquiline Hill) in Rome during the time of the first Emperor, Caesar Augustus (27 bce-14 ce) and later became one of the most famous Imperial gardens around the ancient city. Different types of plant remains such as charcoal, seeds and fruits and pollen were recovered from pits and pots in the garden and reflect the presence of plants there. There seem to have been ornamental shrubs which were probably grown as decorative modelled hedges and/or isolated bushes, as well as cultivated trees. Several ornamental flowering plants grew in pots. Although this archaeobotanical assemblage could represent some patches of wild vegetation still growing in the study area at the time of the Imperial garden, it is likely that most of the identified plants were intentionally planted and organised to create a glimpse of the past wild landscape of Rome. They have special characteristics, such as bearing coloured flowers or fruits and offering shade, that made them suitable for embellishing a magnificent garden. Moreover this reflects the Roman desire to control nature, testified by the expansion of luxury gardens during the Imperial period and the spread of decorative horticultural techniques, like the miniaturisation of trees and shaping of trees and shrubs by topiary.
Die Erfurt-Formation: Ein Beispiel zur Aquifergenese eines Kluftgrundwasserleiters
Authors: Rausch Randolf , Simon Theo , Kiffer Christian 
Published: October 2023

ZusammenfassungBei der Beschreibung von Grundwasserleitern wird davon ausgegangen, dass diese in der Zeit statische Systeme darstellen, d. h. die Grundwasserleiter in Hinblick auf ihre Durchlässigkeit und Speichervermögen sowie auf ihren Lösungsinhalt zeitlich unveränderlich sind. Betrachtet man jedoch die landschaftsgeschichtliche Entwicklung eines Grundwasserleiters über geologische Zeiträume, so erkennt man, dass Grundwasserleiter dynamische Systeme darstellen, die zeitlichen Änderungen unterliegen. Dies wird am Beispiel der Erfurt-Formation in Nord-Württemberg gezeigt. Es lassen sich drei räumliche Bereiche identifizieren, die nebeneinanderliegen und unterschiedlichen Stadien der Aquifergenese entsprechen. Ausgehend von einem Geringleiter entwickelt sich ein gut durchlässiger und ergiebiger Grundwasserleiter, der mit Abnahme der Überdeckung und Verwitterung wieder zu einem Geringleiter wird. Das Beispiel zur Erfurt-Formation zeigt, dass hydrogeologisch verschiedene Bereiche, die heute räumlich nebeneinanderliegen, in einer Schichtstufenlandschaft aufeinanderfolgenden zeitlichen Stadien der Aquifergenese entsprechen. Dieses Modell zur Aquifergenese kann auch auf andere Grundwasserleiter übertragen werden und sollte bei der Charakterisierung eines Grundwasserleiters berücksichtigt werden.
Two-year Follow-up of Habit Reversal Training and Decoupling in a Sample with Body-Focused Repetitive Behaviors
Authors: Moritz Steffen , Hoyer Luca , Schmotz Stella 
Published: October 2023

Abstract
Background
Self-help habit reversal training and decoupling are effective in improving body-focused repetitive behaviors (BFRBs). However, most studies to date on self-help techniques have assessed short-term effects only. The present study aimed to elucidate whether treatment effects would be sustained over a longer period of time.

Methods
We conducted a 2-year follow-up study of a cohort of 391 participants with mixed BFRBs who were initially randomized to four conditions (wait list control, habit reversal training, decoupling, decoupling in sensu). At post assessment, participants were allowed to use other treatment techniques, enabling us to explore treatment effects in those who continued to use the initial method only versus those who used additional techniques. The Generic Body-Focused Repetitive Behavior Scale (GBS-36) served as the primary outcome.

Results
Improvements achieved at post assessment were maintained at follow-up for all experimental conditions, with decoupling showing significantly greater treatment gains at follow-up relative to the wait list control group (last observation carried forward: p = .004, complete cases: p = .015). Depression at follow-up slightly improved compared to baseline and post assessment similarly across all conditions, arguing against “symptom displacement” to other psychopathological syndromes. Retention rates were similarly low across the four conditions (48.5–54.6%), making bias unlikely (but not firmly excluding it). Participants who adhered to the initial protocol until follow-up showed a pattern of improvement similar to those using additional techniques.

Discussion
Our study speaks for the long-term effectiveness of behavioral self-help techniques to reduce BFRBs, particularly decoupling. Of note, participants were allowed to use other self-help manuals after completing the post assessment; thus, randomization was removed. However, a minority of the participants chose this option.
Rvi4 and Rvi15 are the same apple scab resistance genes
Authors: Peil Andreas , Howard Nicholas P , Bühlmann-Schütz Simone , Hiller Ines , Schouten Henk , Flachowsky Henryk , Patocchi Andrea 
Published: October 2023

AbstractThe apple (Malus x domestica) scab (Venturia inaequalis) resistance genes Rvi4 and Rvi15 were mapped to a similar region on the top of linkage group 2 and both resistance genes elicit the same type of resistance reaction, i.e., a hypersensitive response; hence, it is suspected that the two genes may be the same. As the two resistance genes Rvi4 and Rvi15 are currently used in apple breeding, it is important to clarify whether the two resistance genes are the same or not. Several approaches were used to make this determination. First, the pedigree of the genotype GMAL 2473, the source of Rvi15, was reconstructed. GMAL 2473 was found to be an F1 of ‘Russian seedling’, the genotype, which is known to also be the source of Rvi4. Next, it was further demonstrated that ‘Regia’, a cultivar known to carry Rvi4 (and Rvi2), carries the same gene (Vr2-C), which was demonstrated to be the gene inducing Rvi15 resistance. Finally, it was shown that transgenic lines carrying Vr2-C are compatible with race 4 apple scab isolates. Taken all together, these results definitively demonstrate that Rvi4 and Rvi15 are the same resistance gene. For future studies, we suggest referring to this resistance with the first name that was assigned to this gene, namely Rvi4.
GRg1 inhibits the TLR4/NF-kB signaling pathway by upregulating miR-216a-5p to reduce growth factors and inflammatory cytokines in DR
Authors: Xue Liping , Hu Min , Zhu Qin , Li Yadi , Zhou Guanglong , Zhang Xiaofan , Zhou Yuan , Zhang Jieying , Ding Peng 
Published: October 2023

Abstract
Background
Diabetic retinopathy (DR) is a common diabetic neurodegenerative disease that affects vision in severe cases. Current therapeutic drugs are ineffective for some patients with severe side effects, and ginsenoside-Rg1 (GRg1) has been shown to protect against DR and may serve as a new potential drug for DR. This study aimed to confirm the protective effect of GRg1 against DR and its molecular mechanism.

Methods
Human retinal microvascular endothelial cells (hRMECs) and rats were used to construct DR models in vitro and in vivo. Cell proliferation was detected by BrdU assays, the cell cycle was detected by flow cytometry, and TNF-α, IL-6 and IL-1β levels were detected by ELISA. qRT‒PCR, Western blotting and immunohistochemistry were used to detect the expression of related genes and proteins, and angiogenesis assays were used to assess angiogenesis. RIP and RNA pull down assays were used to determine the relationship between miR-216a-5p and TLR4; retinal structure and changes were observed by HE staining and retinal digestive spread assays.

Results
GRg1 effectively inhibited HG-induced hRMEC proliferation, cell cycle progression and angiogenesis and reduced the levels of intracellular inflammatory cytokines and growth factors. HG downregulated the expression of miR-216a-5p and upregulated the expression of TLR4/NF-kB signaling pathway-related proteins. Importantly, GRg1 inhibited TLR4/NF-kB signaling pathway activation by upregulating miR-216a-5p, thereby inhibiting HG-induced cell proliferation, cell cycle progression, angiogenesis, and the production of inflammatory cytokines and growth factors. In addition, animal experiments confirmed the results of the cell experiments.

Conclusions
GRg1 inhibits TLR4/NF-kB signaling by upregulating miR-216a-5p to reduce growth factors and inflammatory cytokines in DR, providing a potential therapeutic strategy for DR.
Characterizing Antarctic fish assemblages using eDNA obtained from marine sponge bycatch specimens
Authors: Jeunen Gert-Jan , Lamare Miles , Devine Jennifer , Mariani Stefano , Mills Sadie , Treece Jackson , Ferreira Sara , Gemmell Neil J. 
Published: October 2023

AbstractInternational conservation goals have been set to mitigate Southern Ocean ecosystem deterioration, with multiple monitoring programs evaluating progress towards those goals. The scale of continuous monitoring through visual observations, however, is challenged by the remoteness of the area and logistical constraints. Given the ecological and economic importance of the Southern Ocean, it is imperative that additional biological monitoring approaches are explored. Recently, marine sponges, which are frequently caught and discarded in Southern Ocean fisheries, have been shown to naturally accumulate environmental DNA (eDNA). Here, we compare fish eDNA signals from marine sponge bycatch specimens to fish catch records for nine locations on the continental shelf (523.5–709 m) and 17 from the continental slope (887.5–1611.5 m) within the Ross Sea, Antarctica. We recorded a total of 20 fishes, with 12 fishes reported as catch, 18 observed by eDNA, and ten detected by both methods. While sampling location was the largest contributor to the variation observed in the dataset, eDNA obtained significantly higher species richness and displayed a significantly different species composition compared to fish catch records. Overall, eDNA read count correlated more strongly with fish abundance over biomass. Species composition correlated on a regional scale between methods, however eDNA signal strength was a low predictor of catch numbers at the species level. Our results highlight the potential of sponge eDNA monitoring in the Southern Ocean by detecting a larger fraction of the fish community compared to catch recordings, thereby increasing our knowledge of this understudied ecosystem and, ultimately, aiding conservation efforts.
Magnetic field map of the Wilhelm Archipelago shelf zone, West Antarctica
Authors: Bakhmutov Volodymyr , Yegorova Tamara , Bakarzhiyeva Mariya , Mytrokhyn Olexandr , Shpyra Viktor , Orlyuk Mykhailo , Maksymchuk Valentyn , Tarasov Viktor , Romenets Andrii , Nakalov Yevheniy , Brillinh Yevhenii , Romanyuk Oleh , Otruba Yurii , Litvinov Dmytro 
Published: October 2023

AbstractThe Antarctic Digital Magnetic Anomaly Project is an international research effort to construct a magnetic map of the continent based on ground, satellite, marine, and aeromagnetic surveys. This paper reports the magnetic mapping of the shelf zone in the SE part of the Wilhelm Archipelago, West Antarctica, based on magnetic surveys conducted with Zodiac boats. A spectacular feature of this area is the strong magnetic anomaly of the Antarctic Peninsula (AP) batholith, which was the product of subduction-related Mesozoic–Cenozoic arc magmatism on the former margin of Western Gondwana. We constructed and analyzed a detailed magnetic map of magnetic field anomalies using field observations of rock exposures on the islands and magnetic properties of rocks from laboratory data. The oldest volcanic rocks of Jurassic to Lower Cretaceous age relate to N-NE trending bands of negative magnetic field. The largest feature in the study area is an Upper Cretaceous/Paleogene granodiorite complex that produces a positive magnetic anomaly. Many smaller anomalies are also present over gabbroid bodies of Cretaceous age. Two-dimensional magnetic modeling shows that heterogeneities in the upper crust may have magnetic susceptibilities in the range of 0.005–0.13 SI. Magnetic field anomalies also delineate an orthogonal system of tectonic faults, including the main NE fault along the Penola Strait (sub-parallel to the AP coastline) and four intersecting faults. These fault systems may be associated with different stages of continental margin evolution along the Antarctic Peninsula.