bluuebunny/crossref_metadata_2025_split huggingface dataset:
Deep learning models to map osteocyte networks can successfully distinguish between young and aged bone
Authors: Vetter Simon D. , Schurman Charles A. , Alliston Tamara , Slabaugh Gregory G. , Verbruggen Stefaan W. 
Published: December 2023

AbstractOsteocytes, the most abundant and mechanosensitive cells in bone tissue, play a pivotal role in bone homeostasis and mechano-responsiveness, orchestrating the intricate balance between bone formation and resorption under daily activity. Studying osteocyte connectivity and understanding their intricate arrangement within the lacunar canalicular network (LCN) is essential for unraveling bone physiology. This is particularly true as our bones age, which is associated with decreased integrity of the osteocyte network, disrupted mass transport, and lower sensitivity to the mechanical stimuli that allow the skeleton to adapt to changing demands. Much work has been carried out to investigate this relationship, often involving high resolution microscopy of discrete fragments of this network, alongside advanced computational modelling of individual cells. However, traditional methods of segmenting and measuring osteocyte connectomics are time-consuming and labour-intensive, often hindered by human subjectivity and limited throughput. In this study, we explore the application of deep learning and computer vision techniques to automate the segmentation and measurement of osteocyte connectomics, enabling more efficient and accurate analysis. We compare several state-of-the-art computer vision models (U-Nets and Vision Transformers) to successfully segment the LCN, finding that an Attention U-Net model can accurately segment and measure 81.8% of osteocytes and 42.1% of dendritic processes, when compared to manual labelling. While further development is required, we demonstrate that this degree of accuracy is already sufficient to distinguish between bones of young (2 month old) and aged (36 month old) mice, as well as capturing the degeneration induced by genetic modification of osteocytes. By harnessing the power of these advanced technologies, further developments can unravel the complexities of osteocyte networks in unprecedented detail, revolutionising our understanding of bone health and disease.
Surpassing Light Inhomogeneities in Structured-Illumination Microscopy with FlexSIM
Authors: Soubies Emmanuel , Nogueron Alejandro , Pelletier Florence , Mangeat Thomas , Leterrier Christophe , Unser Michael , Sage Daniel 
Published: December 2023

AbstractSuper-resolution structured-illumination microscopy (SIM) is a powerful technique that allows one to surpass the diffraction limit by up to a factor two. Yet, its practical use is hampered by its sensitivity to imaging conditions which makes it prone to reconstruction artifacts. In this work, we present FlexSIM, aflexibleSIM reconstruction method capable to handle highly challenging data. Specifically, we demonstrate the ability of FlexSIM to deal with the distortion of patterns, the high level of noise encountered in live imaging, as well as out-of-focus fluorescence. Moreover, we show that FlexSIM achieves state-of-the-art performance over a variety of open SIM datasets.
Re-assessment of the subcellular localization of Bazooka/Par-3 inDrosophila: No evidence for localization to the nucleus and the neuromuscular junction
Authors: Kim Soya , Shahab Jaffer , Wodarz Andreas 
Published: December 2023

AbstractBazooka/Par-3 (Baz) is an evolutionarily conserved scaffold protein that together with its binding partners atypical protein kinase C (aPKC) and Par-6 forms the Par complex. This protein complex functions as a master regulator for the establishment and maintenance of cell polarity in many different cell types. In the vast majority of published research papers Par complex members have been reported to localize at the cell cortex and at intercellular junctions. However, there have also been several reports claiming localization and function of Par complex members at additional subcellular sites, in particular the nucleus, the nuclear envelope and the neuromuscular junction. In this study we have re-assessed this issue for Baz in a systematic manner. We used a variety of antibodies raised in different host animals against different epitopes of Baz for confocal imaging ofDrosophilatissues. We tested the specificity of these antisera by using mosaic analysis with null mutantbazalleles and tissue-specific RNAi againstbaz.In addition, we used a GFP-tagged gene trap line for Baz and a bacterial artificial chromosome (BAC) expressing GFP-tagged Baz under control of its endogenous promoter in abaznull mutant background to compare the subcellular localization of the respective GFP-Baz fusion proteins to the staining results with anti-Baz antisera. Together, these experiments did not provide any evidence for specific localization of Baz to the nucleus or the neuromuscular junction.
Umbrella protectors? Analysing valuing, hybridity and compromises for Chinese middle managers
Authors: Ren Chao , Situ Hui , Vesty Gillian Maree 
Published: December 2023

PurposeThis paper examines the ways in which Chinese university middle managers evaluate subordinate performance in response to the Chinese Double First-Class University Plan, a national project that ranks the performance of universities. In exploring compromise arrangements, the hybridised valuing activity of middle managers is found to be shaped by emergent and extant macro-foundations.Design/methodology/approachThe qualitative data from 49 semi-structured interviews at five Chinese public universities were conducted. Drawing on macro-foundational studies and the sociology of worth (SW) theory, the analysis helps to identify socially shared patterns of actions and outcomes.FindingsThe findings elucidate the interplay between diverse economic, social, political and institutional values and the compromise-making by middle managers. The authors find that contextual factors restrict Chinese academic middle managers' autonomy, preventing workable compromise. Through the selective adoption of international and local management practices, compromise has evolved into a private differential treaty at the operational level.Originality/valueA nuanced explanation reveals how the macro-foundations of Chinese society influence middle managers who engage with accounting when facilitating compromise. This study helps outsiders better understand the complex convergence and divergence of performance evaluative practices in Chinese universities against the backdrop of global market-based forces and the moral dimensions of organisational life. The findings have wider implications for the Chinese government in navigating institutional steps and developing supportive policies to enable middle managers to advance productive but also sustainable compromise.
A decision model for international market selection by entrepreneurs: a cross-country investigation
Authors: Al Qur’an Marwan N. 
Published: December 2023

Purpose
This study aims to examine the international market selection process of entrepreneurs operating internationally.

Design/methodology/approach
Four small and medium-sized comparative and rich-information case studies were purposefully selected from among Australian and Arabian firms. Data were collected via in-depth personal interviews, follow-up interviews and questionnaire instrument.

Findings
The results revealed that entrepreneurs used a four-stage systematic decision-making process to attain profitable foreign market choices. The decision process was influenced by cognitive boundaries as entrepreneurs relied on the availability experiential, anchoring and adjustment heuristic.

Research limitations/implications
The research’s findings and the proposed decision model will, significantly, assist entrepreneurs, willing to expand internationally, in enhancing their decision-making to attain profitable foreign market choices. Further, it provides benefits to foreign investment policymakers in host countries by assisting them to attract more inward foreign direct investments, and, accordingly, enhance the economic and social development movement in their countries.

Originality/value
This study provides a significant theoretical contribution to the literature on the internationalization process of entrepreneurs and small- and medium-sized enterprises through developing a decision model for selecting and entering foreign markets by entrepreneurs in a cross-country context. Further, the study provides significant methodological contributions with regard to the effectiveness of the qualitative case study method in capturing elements of the foreign market selection process.
A new adaptive grey seasonal model for time series forecasting tasks
Authors: Wang Ran , Xu Yunbao , Yang Qinwen 
Published: December 2023

PurposeThis paper intends to construct a new adaptive grey seasonal model (AGSM) to promote the application of the grey forecasting model in quarterly GDP.Design/methodology/approachFirstly, this paper constructs a new accumulation operation that embodies the new information priority by using a hyperparameter. Then, a new AGSM is constructed by using a new grey action quantity, nonlinear Bernoulli operator, discretization operation, moving average trend elimination method and the proposed new accumulation operation. Subsequently, the marine predators algorithm is used to quickly obtain the hyperparameters used to build the AGSM. Finally, comparative analysis experiments and ablation experiments based on China's quarterly GDP confirm the validity of the proposed model.FindingsAGSM can be degraded to some classical grey prediction models by replacing its own structural parameters. The proposed accumulation operation satisfies the new information priority rule. In the comparative analysis experiments, AGSM shows better prediction performance than other competitive algorithms, and the proposed accumulation operation is also better than the existing accumulation operations. Ablation experiments show that each component in the AGSM is effective in enhancing the predictive performance of the model.Originality/valueA new AGSM with new information priority accumulation operation is proposed.
Assembly line balancing and capacity evaluation based on interval grey processing time
Authors: Dang Zihan , Xie Naiming 
Published: December 2023

PurposeAssembly line is a common production form and has been effectively used in many industries, but the imprecise processing time of each process makes production line balancing and capacity forecasting the most troublesome problems for production managers. In this paper, uncertain man-hours are represented as interval grey numbers, and the optimization problem of production line balance in the case of interval grey man-hours is studied to better evaluate the production line capacity.Design/methodology/approachFirst, this paper constructs the basic model of assembly line balance optimization for the single-product scenario, and on this basis constructs an assembly line balance optimization model under the multi-product scenario with the objective function of maximizing the weighted greyscale production line balance rate, second, this paper designs a simulated annealing algorithm to solve problem. A neighborhood search strategy is proposed, based on assembly line balance optimization, an assembly line capacity evaluation method with interval grey man-hour characteristics is designed.FindingsThis paper provides a production line balance optimization scheme with uncertain processing time for multi-product scenarios and designs a capacity evaluation method to provide managers with scientific management strategies so that decision-makers can scientifically solve the problems that the company's design production line is quite different from the actual production situation.Originality/valueThere are few literary studies on combining interval grey number with assembly line balance optimization. Therefore, this paper makes an important contribution in this regard.
Two-phase flow regime identification using multi-method feature extraction and explainable kernel Fisher discriminant analysis
Authors: Khan Umair , Pao William , Pilario Karl Ezra Salgado , Sallih Nabihah , Khan Muhammad Rehan 
Published: December 2023

Purpose
Identifying the flow regime is a prerequisite for accurately modeling two-phase flow. This paper aims to introduce a comprehensive data-driven workflow for flow regime identification.

Design/methodology/approach
A numerical two-phase flow model was validated against experimental data and was used to generate dynamic pressure signals for three different flow regimes. First, four distinct methods were used for feature extraction: discrete wavelet transform (DWT), empirical mode decomposition, power spectral density and the time series analysis method. Kernel Fisher discriminant analysis (KFDA) was used to simultaneously perform dimensionality reduction and machine learning (ML) classification for each set of features. Finally, the Shapley additive explanations (SHAP) method was applied to make the workflow explainable.

Findings
The results highlighted that the DWT + KFDA method exhibited the highest testing and training accuracy at 95.2% and 88.8%, respectively. Results also include a virtual flow regime map to facilitate the visualization of features in two dimension. Finally, SHAP analysis showed that minimum and maximum values extracted at the fourth and second signal decomposition levels of DWT are the best flow-distinguishing features.

Practical implications
This workflow can be applied to opaque pipes fitted with pressure sensors to achieve flow assurance and automatic monitoring of two-phase flow occurring in many process industries.

Originality/value
This paper presents a novel flow regime identification method by fusing dynamic pressure measurements with ML techniques. The authors’ novel DWT + KFDA method demonstrates superior performance for flow regime identification with explainability.
Energy, gender and development: the impact of energy efficient cookstoves intervention on the welfare of women in Ethiopia
Authors: Sepee Sankaa , Tesfahun Azmeraw Ayehu 
Published: December 2023

Purpose
The use of energy efficient cookstoves (EECS) has been promoted for a long and considered as instrumental in the efforts to mitigate the multiple social, economic and environmental consequences of traditional biomass cookstoves. Despite this, the adoption of EECS in pre-urban and rural Ethiopia is still very low. In response to this, the government of Ethiopia, in collaboration with international development organizations, implemented numerous initiatives aimed at improving the availability and use of EECS as part of the effort to support sustainable development. However, very little is known about the impact of the introduced EECS on improving the welfare of women. The purpose of this study is, therefore, to assess the impact of improved cookstoves projects on the welfare of women in Yaya Gullele district, Ethiopia.

Design/methodology/approach
A mixed research design was adopted to conduct the study. The quantitative data for the study were collected using a structured questionnaire by interviewing 388 randomly selected respondents. The data were analysed using both descriptive and inferential data analysis techniques, including the propensity score matching model using STATA.

Findings
Results of the study revealed that adoption of EECS has reduced fuel wood expense (124.65 Ethiopian Birr [ETB]/week), reduced five-year stove expense (404.67 ETB) and increased regular savings (116.58 ETB/month), which contributed for an increased annual income of participants (5,594.42 ETB). The result of the study also indicated that the use of EECS enabled the beneficiary women to reduce the amount of fuel wood use by 29.4 kg/week, which in turn reduced forest degradation and emission by 2.34 tons of CO2e/year/household. Besides, it reduced the drudgery on women in terms of reduced time to cook (53 min/day), reduced time to collect fuelwood and prepare food (3.95 h/week) and reduced frequency of fuelwood collection trips (3.42 trips/week). The study results, in general, indicated that the adoption of EECS improved the welfare of women in the study area, where the majority of women have been suffering from the burden of using traditional stoves and associated impacts for a long.

Practical implications
Energy is central to most of the development-related challenges and opportunities every country faces today. The result of the study implied that policies and strategies intended at improving the availability and use of EECS as part of the effort to support sustainable development need to consider integrating such context-referenced, locally manageable and affordable EECS into the clean developmental strategies of the country.

Originality/value
Insights from this study can support development practitioners and policymakers to make informed decisions regarding future interventions in the use of energy efficient that have the potential to several economic, social and environmental positive development outcomes.
Implementation of work-life balance strategies among construction companies in Lagos, Nigeria: construction workers’ perspectives
Authors: Osuizugbo Innocent Chigozie , Oshodi Olalekan Shamsideen , Kukoyi Patricia Omega , Yohanna Hosea Shemang , Edike Uche Emmanuel 
Published: December 2023

Purpose
The construction industry in Nigeria has a complex environment, comprising several combinations of consulting professions, clients, contractual arrangement and investors, with longer working hours than other industries. Work–life balance (WLB) strategies are used to balance professional life and personal life. This study aims to assess the extent of implementation of WLB strategies among construction companies in Lagos, Nigeria.

Design/methodology/approach
This study adopts a survey research technique. Snowball sampling technique was adopted to identify the targeted respondents for the administration of questionnaire. A total of 156 questionnaires were distributed and a response rate of 66% (103 questionnaires were completely filled and returned) was attained. Data elicited were analysed using descriptive and inferential statistics.

Findings
Results from this study provides evidence that the level of implementation of WLB strategies among construction companies in Lagos state, Nigeria is on the average. The results also revealed organisational understanding, paternity/maternity leave and flexible working arrangement as the top most three WLB strategies implemented among the construction companies in Lagos, Nigeria.

Originality/value
This study contributed to more effective WLB studies by identifying new information on the extent of usage of WLB practices in the Nigerian construction sector as well as offers a fresh perspective on the usage of WLB in a developing country. An understanding of these strategies is significant for companies’ stakeholders, such as management personnel, top construction professionals and policymakers, and for facilitating the adoption and implementation of WLB strategies among construction organisations.
What drives the effectiveness of public startup support programs? Empirical insights from the “EXIST-business startup grant”
Authors: Mueller Christoph Emanuel 
Published: December 2023

PurposeIn a recent quasi-experimental study, the effects of a large German public startup support measure entitled “EXIST – Business Startup Grant” (EGS) on a variety of outcomes were determined, but without examining which factors are responsible for these program effects. The present study investigates the contribution of several factors to the success of the program in promoting product development and business planning.Design/methodology/approachBy means of a two-wave panel design and fixed-effects panel regressions, evidence is generated that provides unique insights into the effect mechanisms of a publicly funded startup grant. The data for the study come from the program monitoring of the startup support measure.FindingsSeveral factors were identified that significantly drive the effects of the program on the product development and business planning stages, namely the program-induced improvement of the skills of the startup team, intensification of cooperation with pilot customers/users, increase in the degree of networking and advice/support from third parties and the effort put into business plan preparation.Originality/valueStartup support programs are a crucial aspect of technology and innovation policies, which are often evaluated in order to find out whether they generate effects. Assessing whether a program is effective or not, however, does not usually allow specific recommendations on how to improve the measure to be developed. Further information on the mechanisms of intervention is needed for this purpose. The present study takes up on this idea and provides this information for a specific type of public startup support measure.
Further evidence on non-audit fees: using the context of female directors on audit committees
Authors: Abbasi Kaleemullah , Alam Ashraful , Brohi Noor Ahmed , Nasim Shahzad 
Published: December 2023

Purpose
This study aims to examine the association between non-audit fees and audit quality by using the context of gender-diverse audit committees. Further, the authors assess whether this link is moderated by industry-specialist auditors.

Design/methodology/approach
This study used non-financial FTSE-350 firms over the period of seven years. In addition, the authors use ordinary least squares regression to test the research hypotheses.

Findings
The authors find that female directors on audit committees are negatively related to non-audit fees, suggesting that non-audit fees reduce audit quality. Moreover, the results indicate that industry-specialist auditors positively moderate the link between gender-diverse audit committees and non-audit fees. This suggests that non-audit fees improve audit quality when the auditor is an industry-specialist.

Practical implications
The study does not support blanket restrictions on non-audit fees. It recommends regulators to consider industry expertise of auditors when devising non-audit fee restrictions. Moreover, the findings of this study have implications for firms aiming to understand whether non-audit fees could be used for enhancing audit quality.

Originality/value
By using the context of female directors on audit committees, the authors conclusively assess the link between non-audit fees and audit quality. Further, this study provides a more robust evidence on whether industry-specialist auditors affect the relationship between non-audit fees and audit quality.
Is halal tourism taking off in OIC and non-OIC countries? A systematic study of published research
Authors: Mohsin Asad , Rodrigues Helena , Penela Daniela , Luz Ana 
Published: December 2023

Purpose
The purpose of this study is to systematically examine and compare the growth of halal tourism and hospitality in OIC and non-OIC countries based on published literature.

Design/methodology/approach
A critical systematic review of 154 academic papers published in the last decade involving halal tourism in OIC and non-OIC countries constituted the sample for this study. The study uses an integrated antecedents, decisions and outcomes and theories, contexts and methods framework, and a coding protocol based on the preferred reporting items for systematic reviews and meta-analyses.

Findings
Halal tourism is not developed in non-OIC countries where Islam does not predominate, which represents an opportunity for many countries to incorporate new trends in their tourism offerings. This research increases awareness of non-OIC destinations to welcome a growing halal tourism market, enabling them to foster innovation to meet new demands for Muslim travelers.

Originality/value
This study is different as we compare the pertinent needs that are based on religion in various geographical locations while focusing on tourism and hospitality research in Islamic and non-Islamic nations.