bluuebunny/crossref_metadata_2025_split huggingface dataset:
Evaluation of a flexible piecewise linear mixed‐effects model in the analysis of randomized cross‐over trials
Authors: Mwangi Moses , Verbeke Geert , Njagi Edmund Njeru , Florez Alvaro Jose , Mwalili Samuel , Ivanova Anna , Bukania Zipporah N. , Molenberghs Geert 
Published: December 2023

AbstractCross‐over designs are commonly used in randomized clinical trials to estimate efficacy of a new treatment. They have received a lot of attention, particularly in connection with regulatory requirements for new drugs. The main advantage of using cross‐over designs over conventional parallel designs is increased precision, thanks to within‐subject comparisons. In the statistical literature, more recent developments are discussed in the analysis of cross‐over trials, in particular regarding repeated measures. A piecewise linear model within the framework of mixed effects has been proposed in the analysis of cross‐over trials. In this article, we report on a simulation study comparing performance of a piecewise linear mixed‐effects (PLME) model against two commonly cited models—Grizzle's mixed‐effects (GME) and Jones & Kenward's mixed‐effects (JKME) models—used in the analysis of cross‐over trials. Our simulation study tried to mirror real‐life situation by deriving true underlying parameters from empirical data. The findings from real‐life data confirmed the original hypothesis that high‐dose iodine salt have significantly lowering effect on diastolic blood pressure (DBP). We further sought to evaluate the performance of PLME model against GME and JKME models, within univariate modeling framework through a simulation study mimicking a 2 × 2 cross‐over design. The fixed‐effects, random‐effects and residual error parameters used in the simulation process were estimated from DBP data, using a PLME model. The initial results with full specification of random intercept and slope(s), showed that the univariate PLME model performed better than the GME and JKME models in estimation of variance–covariance matrix (G) governing the random effects, allowing satisfactory model convergence during estimation. When a hierarchical view‐point is adopted, in the sense that outcomes are specified conditionally upon random effects, the variance–covariance matrix of the random effects must be positive‐definite. The PLME model is preferred especially in modeling an increased number of random effects, compared to the GME and JKME models that work equally well with random intercepts only. In some cases, additional random effects could explain much variability in the data, thus improving precision in estimation of the estimands (effect size) parameters.
Study of drug structures using topological descriptors and multi‐criteria decision making
Authors: Zhang Chuanhong , Sui Ruiqing , Kanwal Salma , Tawfiq Ferdous M. , Farooq Yasmeen , Aslam Adnan 
Published: December 2023

AbstractIt has been observed that there is a strong correlation between topological descriptors of chemical structures and their physical properties in a number of tests every year. There are several of these characteristics, including molecular mass, density, melting and boiling points, flash points, and others. Topological indices are numerical numbers associated with the molecular graph and are used in quantitative structure property relationship studies to predict their physical and chemical properties. In this work, we have calculated the reverse degree based topological descriptors of five molecular structures namely, hyaluronic acid–paclitaxel conjugates (), anticancer drug (), polyomino chain of ‐cycle (), triangular benzenoid (), and circumcoronene benzenoid series (). The values of topological indices are used in entropy method to calculate the weights. Then, using multiple criteria decision‐making techniques like COPRAS and PROMETHEE, we rank these molecular structures.
Intermolecular interaction characteristics of the Boron‐nitrogen rings, and with hexagonal boron nitride: A special molecular adsorption and weak interaction
Authors: Zha Peng , Jiang Shuaijie , Wang Pengcheng 
Published: December 2023

AbstractWith the discovery of cyclo[18]carbon, related theoretical research has become a very hot topic. Due to its unique molecular structure, many derivatives have been derived, especially its isoelectronic molecule cyclo B9N9. This work focused on the interaction between cyclo B9N9 molecules and explored the nature of their interaction. The interaction of the dimer of cyclo B9N9 was studied, quantum chemical calculation and wave function analysis were carried out, and compared with cyclo[18]carbon to find its commonness. It showed that the interaction between the cyclo B9N9 dimers is a weak electron generating stacking interaction. In addition, the adsorption of cyclo B9N9 was studied, and the interaction of graphene analogues hexagonal boron nitride (h‐BN). Through calculation and analysis, it was found that the adsorption of cyclo B9N9 was much stronger than that of cyclo[18]carbon. In another sense, the π–π stacking interaction of boron nitrogen structure is stronger than that of carbon. To further validate this commonality, B6N6 was selected for the same calculation, and similar conclusions were obtained. It was also found that the more Boron nitrogen (BN), the stronger the stacking interaction.
Robust output regulation for a flexible wing system with unknown output disturbances and references
Authors: Meng Tingting , Fu Qiang , Huang Haifeng , Zhang Shuang 
Published: December 2023

AbstractFor a flexible wing system, two different exosystems are used to generate unknown references and output disturbances, respectively. The wing system is further perturbed by unknown distributed and boundary disturbances that have the same frequencies to the references and output disturbances. This article proposes two robust control methodologies to address the robust output regulation of the wing. At first, the observer based output feedback controls are designed based on state feedback controls and the following observers: (1) two exosystem observers based on tracking errors; (2) two exosystem observers addressing the uncertainties of output disturbances; (3) the PDE observer estimating the wing states. For the closed‐loop system, the tracking errors are proved to be exponentially convergent toward zero. Let the output disturbances be addressed through two adaption laws, not the observers in the above item (2), which together with other two exosystem observers and the PDE observer, gives observer based adaptive controls. From both cases, we obtain that the exosystem observers based on the tracking errors are necessary for the robust output regulation. By comparison, the former robust controls have a lower dimension and concise structure. Simulation examples have been provided to show the effectiveness of the robust controls.
Use of an unmanned aerial‐aquatic vehicle for acoustic sensing in freshwater ecosystems
Authors: Lawson Jenna , Farinha Andre , Romanello Luca , Pang Oscar , Zufferey Raphael , Kovac Mirko 
Published: December 2023

AbstractFreshwater ecosystems are endangered, underfunded and understudied, making new methods such as passive acoustic monitoring (PAM) essential for improving the efficiency and effectiveness of data collection. However, many challenges are still to be addressed with PAM: difficulty in accessing research sites, the logistics of implementing large‐scale studies and the invasiveness of data collection. When combined with PAM and other sensing strategies, mobile robotics are a promising solution to directly address these challenges. In this paper, we integrate water surface and underwater acoustic monitoring equipment onto a prototype unmanned aerial‐aquatic vehicle (UAAV) capable of sailing and flight (SailMAV). Twelve autonomous sailing missions were run on Lake Vrana, Croatia, during which acoustic data were collected, and the ability of the UAAV to facilitate the collection of acoustic data demonstrated. Data were simultaneously collected using standard recording methods on buoys and banksides to provide a comparative approach. Acoustic indices were used to analyse the soundscape of underwater acoustic data and BirdNET (a deep artificial neural network) was used on water surface datasets to determine bird species composition. Results show higher species richness and call abundance from UAAV surveys and high site dissimilarity owing to turnover between stationary and UAAV methods. This highlights the success of the UAAV in detecting biodiversity and the complementarity of these methods in providing a broad picture of the biodiversity of freshwater ecosystems. Increased bird diversity and underwater acoustic activity in protected areas demonstrate the benefits of protecting freshwater ecosystems; however, site dissimilarity driven by turnover highlights the importance of protecting the entire ecosystem. We show how, by integrating PAM and a UAAV, we can overcome some of the current challenges in freshwater biodiversity monitoring, improving accessibility, increasing spatial scale and coverage, and reducing invasiveness.
Early eukaryotic microfossils of the late Palaeoproterozoic Limbunya Group, Birrindudu Basin, northern Australia
Authors: Riedman Leigh Anne , Porter Susannah M. , Lechte Maxwell A. , dos Santos Angelo , Halverson Galen P. 
Published: December 2023

AbstractFine‐grained, siliciclastic units of the >1642 ± 3.9 Ma late Palaeoproterozoic Limbunya Group, Birrindudu Basin host rich, well‐preserved organic‐walled microfossil assemblages that include members of total‐group eukaryotes. These assemblages include taxa characteristic of this interval such asTappania planaandSatka favosa, as well as less common taxa such asGigantosphaeridium fibratum,Gigantosphaeridium floccosum,Kamolineata elongata(= Valeria elongata; new combination), and four new species. The new taxa includeLimbunyasphaera operculatagen et sp. nov., the oldest known operculate taxon; the large septate filaments ofSiphonoseptum bombycinumgen. et sp. nov.; the platy tubular formBirrindudutuba brigandiniagen. et sp. nov.; andFilinexum torsivumgen. et sp. nov., which bears a spirally twisted wall constructed of bound fibres. Our data show that eukaryotic fossils are particularly abundant in marginal marine environments such as tidal flats and back‐barrier lagoonal settings. This is exemplified by the Blue Hole Formation, which features an especially diverse and complex assemblage. We also present a new within‐formation eukaryotic species richness estimate for the Palaeoproterozoic to Tonian. This estimate indicates that the oldest eukaryote‐bearing units already show species richness levels similar to those of the much younger and more heavily sampled Tonian period. Additionally, these oldest eukaryotic assemblages show significant morphological disparity, particularly in vesicle construction. These high levels of eukaryotic species richness and morphological disparity suggest that although late Palaeoproterozoic units preserve our oldest record of eukaryotes, the eukaryotic clade has a much deeper history.
What's in the Syllabus? Deconstructing Global Englishes Course Syllabi
Authors: Selvi Ali Fuad 
Published: December 2023

AbstractDespite the recent proliferation of Global Englishes courses both quantitatively (in terms of the number of programs offered worldwide) and qualitatively (in various sizes, forms, modes, and modalities), large‐scale systematic investigations across various contexts are conspicuously underrepresented within the existing body of literature. Departing from this foundational premise, the current study seeks to address this gap through an exploratory content analysis of Global Englishes course syllabi (n = 104) offered within English, TESOL, or applied linguistics programs situated in diverse geographical settings. Positioning course syllabi as a primary data source and deconstructing them with a critical interpretative lens offer powerful insights into teacher educators' positionality of Global Englishes and the pedagogical parameters that shape their instructional decisions. Research results indicated that the courses within the dataset predominantly positioned Global Englishes in terms of its globalinguistic status, geospatial variation, and the heterogeneity characterizing its uses and users. Furthermore, the pedagogical goals of these courses primarily gravitated toward the cultivation of lower‐order thinking skills mainly through scholarship emanating from the Global North and were assessed by written assignments, examinations, and oral presentations. The apparent gap in pedagogical content, practices, and experiences needed to cultivate a robust professional knowledge base centered on Global Englishes suggests that these courses, as currently structured, run the risk of being perceived merely as “politically correct”, tokenistic and trivialized additions “about” and not “for” Global Englishes.
“Good for me to Leave it for Good”: A Longitudinal Study on How Emotion Labor in Teaching Contributes to a Beginning EFL Teacher's Resignation
Authors: Zhang Yujie , Zhang Lawrence Jun 
Published: December 2023

AbstractSeldom have studies linked the early‐career teacher attrition problem to teachers' emotion labor, especially with a longitudinal design. Grounded in the poststructural approach, we designed a longitudinal study to investigate qualitatively how a second‐year English‐as‐a‐foreign‐language (EFL) teacher's emotion labor triggered by implicit feeling rules contributed to her resignation. We interviewed the novice EFL teacher about her experiences of teaching practice and emotion labor. Findings revealed that: (1) The sources of feeling rules could be complex but were mainly institutional wills, professional norms, and social expectations; (2) many factors triggering emotion labor existed in educational institutions, indicating the necessity of institutional reform; (3) the long‐term residual effects of emotion labor led to teacher attrition through the mediation of elevated burnout and decreased teacher wellbeing. Our study considers the teacher's resignation as her resistance to feeling rules and provides empirical evidence for the link between the power imbalance behind emotion labor and early‐career resignation. These findings point to a possible need for institutional support and reform as effective methods to increase teachers' wellbeing and career longevity.
“It's Just a Feeling!”: Emotions and Intersectionality in Language Teacher Narratives
Authors: Vitanova Gergana 
Published: December 2023

AbstractLanguage teacher identities and emotions are deeply sociocultural phenomena. Although intersectionality has asserted itself as a powerful framework in other fields, it is just beginning to emerge in language teacher education. This article argues that intersectionality provides a powerful conceptual lens for analyzing the complex and varied connections between language teacher identity and emotions. It also claims that emotions originate in the spaces between different social factors. Specifically, the article investigates the following questions: How do English‐as a‐second‐language teachers construct their emotions in narratives and what discourses of emotion do they evoke? How are emotions generated within the intersectional spaces of facets of their social identities? To address these, the article focuses on the micro‐level of analysis and the daily emotional experiences of two language teachers. The findings show how the focal participants navigate the complex emotional landscapes of teaching and how these are mediated by the intersections of different social identity markers such as gender, race, non‐native speaking status, and socioeconomic status.
Propofol‐induced LINC01133 inhibits the progression of colorectal cancer via miR‐186‐5p/NR3C2 axis
Authors: Yao Yingying , Zhang Fang , Liu Feiyu , Xia Daolin 
Published: December 2023

AbstractColorectal cancer (CRC) is a formidable threat to human well‐being, characterized by a largely enigmatic occurrence and progression mechanism. A growing body of literature has underscored the potential influence of propofol, a frequently administered anesthetic, on clinical outcomes in malignant tumor patients. However, the precise molecular mechanisms underlying the impact of propofol on the progression of CRC have yet to be fully elucidated. This study reveals a notable upregulation of LINC01133 expression in CRC cells subsequent to propofol treatment, which is mediated by FOXO1. Subsequently, a series of experiments were conducted to elucidate the role and mechanisms underlying propofol‐induced LINC01133 in CRC development. Our study uncovers that the upregulation of LINC01133 exerts a substantial inhibitory effect on the proliferation, migration, and invasion of CRC cells. Further investigation revealed that LINC01133 can attenuate the proliferation, invasion, and migration of CRC cell lines through the miR‐186‐5p/NR3C2 axis. Results from in vivo experiments unequivocally demonstrated a significant reduction in the growth rate of subcutaneous implant tumors upon LINC01133 overexpression in CRC cells. These findings posit that propofol induces LINC01133 expression, leading to the inhibition of CRC progression. This revelation offers a novel perspective on propofol's antitumor properties and underscores the potential of LINC01133 as a promising therapeutic target for CRC.
From Teacher to Literacy Coach: Negotiating Roles and Learning on the Job
Authors: Ruesink Leah , Teichert Laura 
Published: December 2023

AbstractThis paper responds to Ippolito et al.'s (2021) “wonder,” “What preparation and in‐service support do coaches need to become systems thinkers, thought leaders, and change agents within their schools” (p. 182) by describing the obstacles and complexities experienced by two first‐year literacy coaches as they transitioned from classroom teacher to coach. They described challenges related to adult learning principles and communication (e.g., questioning) and understanding their role and position when working with teachers. Ultimately, they wanted to feel valuable to teachers but did not know what that looked like. The findings from this paper highlight the need for specific training in negotiating roles within relationships and adult learning principles. Coaches must understand adult‐centered communication and receive ongoing professional learning to develop a repertoire of adult communication strategies that will help them work with a broad swath of teachers.
Lying deadwood retention affects microhabitat use of martens (Martes spp.) in European mountain forests
Authors: Schwegmann Sebastian , Storch Ilse 
Published: December 2023

Biodiversity loss due to intensive timber production is a ubiquitous conservation issue across temperate and boreal forest ecosystems. Retention forestry, the retention of deadwood and old‐growth features within production forest, is one management strategy that has been implemented in various countries around the world to conserve a wide range of taxa within managed forests. The success and ecological implications of retention forestry are currently subject to intensive investigation and while some taxa like birds and insects have already been studied frequently, larger mammals have received less attention. Pine martens are one of the few larger mammals in central Europe preferring older forest and potentially profiting directly from deadwood retention as a consequence of implemented retention forestry. The goal of our study was to assess the response of European marten species to deadwood retention in montane mixed forests. Using marten detection rates from camera traps on 135 research plots we assessed the response of martens to deadwood at three different spatial scales using generalized linear mixed models. We found no effect of lying deadwood on marten detections at the plot scale (1 ha) or in a 10 m radius around the camera traps. However, we found a significant increase of marten detections if logs (> 10 cm in diameter) were directly in front and in view of the camera trap. Our results show that deadwood retention as a measure of retention forestry does affect microhabitat use of martens, but not stand selection during the growing season. Logs directly in view of the camera trap increase marten detection rates as martens choose to move and forage along fallen trees when they are available. When using camera trapping to collect data on martens, trap positioning in front of logs can heavily bias trapping results when unaccounted for.Keywords: beech marten, camera trapping, deadwood, logs, pine marten, retention forestry
Alternative Strategies for the Optimal Combination of GNSS and Classical Geodetic Networks: A Case-Study in Greece
Authors: Ampatzidis Dimitrios , Tzanou Eleni , Demirtzoglou Nikolaos , Vergos Georgios S. 
Published: December 2023

AbstractThe present study discusses two alternative strategies for the optimal combination of different geodetic reference frames in a rigorous way. The methodological variations stem from the (un)availability and types of the 3D network observables. The alternative strategies are tested in Drama region, Northern Greece, where two local networks were established; a 3D one expressed in ITRF2008 (a modern GNSS network established for precise surveying) and a classical one which refers to the official Greek Geodetic Reference System, the Hellenic Geodetic Reference System of 1987. The concept of the proposed strategy is based on the rigorous combination of the different networks at the Normal Equation (NEQ) level. The zenith angles play crucial role for the implementation of the alternative strategies, especially for the correct use of the vertical information. The results of the case study show that the combined solutions provide generally a good level of consistency with the individual networks (GNSS and conventional land surveying).
Experience, Institutions, and the Lived Welfare State
Authors: Annola Johanna , Lindberg Hanna , Markkola Pirjo 
Published: December 2023

AbstractIn this introductory chapter, Annola, Lindberg, and Markkola introduce the theoretical and historiographical foundations of the book. The authors contextualize the history of experience in the traditions of new social history, cultural and linguistic turns, the GermanErfahrungsgeschichte, and the history of emotions and senses. Focusing on institutions introduced by the state and developed by the welfare state mainly in the area surrounding the Baltic Sea, the chapter shows the various ways in which institutions that have shaped people’s everyday lives can be studied. By combining the history of experiences with the history of the welfare state and institutional studies, the chapter seeks new ways to understand how institutions have produced, reinforced, and sometimes prevented various experiences. The concept “lived institutions” is used to illuminate the interconnections between experience and welfare institutions and the ways in which these mutual connections are related to societal change. The introduction ends with a chapter-by-chapter outline of the book.
Stories of Silence, Echoes of Events: The Family as a Changing Site of Illness
Authors: Meier Marie 
Published: December 2023

AbstractToday, citizens in many western countries are increasingly confronted with questions of mental health. In the mid-twentieth century, mental issues were not a subject commonly debated in public. Rather, the shame connected to so-called nervous diseases caused many families to conceal the mental distress of a family member. Drawing on and unpacking three oral history interviews, this chapter explores how the family as an institution has formed a changing site of illness. Following ecological approaches to mental suffering, it more specifically shows how the changing dynamics of secrecy and disclosure within families have shaped and determined how mental illness has been experienced. In doing so, the chapter offers a novel lens on how secrecy, as a kind of knowledge management, has intersected with broader societal and cultural developments and shaped the situated and historically contingent experiences of mental suffering.