bluuebunny/crossref_metadata_2025_split huggingface dataset:
Positive Psychological Group Intervention for Non-suicidal self-injury Adolescents： A Pragmatic Randomized Controlled Trial
Authors: Yan Hu , RUI Zhao , YueGe Li , Han Kong , shuying Chang 
Published: January 2024

Abstract
Introduction:The effectiveness of Positive Psychological Group intervention (PPGI) in the treatment of non-suicidal self-injury (NSSI) remains to be explored.
Objective: Non-suicidal self-injury (NSSI) is prevalent among adolescents and associated with negative medical and psychological consequences, necessitating its treatment. However, few treatments have been developed to treat NSSI specifically or to treat the behavior among individuals without borderline personality disorder. The purpose of this study was to investigate the PPGI, a brief, behavioral intervention specifically developed to treat NSSI among adolescents, in a pilot randomized controlled trial (RCT).
Method: Forty adolescents meeting inclusion and exclusion criteria were randomly assigned to the treatment (PPGI; n = 20) or treatment as usual (TAU; n = 20) condition. The sample was 83.3% female, and 100% Asian. Our main results are the frequency of NSSI and the individual's positive and negative emotions. As secondary outcomes, we will assess changes in the sense of self-efficacy and growth mindset. Due to the subjectivity of scale measurement, this study will also use objective data such as functional Magnetic Resonance Imaging (fMRI) to measure the effect of intervention.
Results:After 6 weeks of intervention, the OSI score (P<0.001) and negative emotion score (P<0.001) in the PPGI group were significantly lower than those in the control group. Positive emotion scores (P<0.001), GSES (P<0.001), and GMS (P<0.001) were significantly higher than those in the control group. Functional Magnetic Resonance Imaging (fMRI) showed that brain function activity in the frontal lobe area was significantly lower than before the intervention (P<0.001). In addition, the control group also showed some effects in improving negative emotions.
Conclusion: Results of this study support the further evaluation of T-PPGI in a larger RCT.
Clinical Trial Registration: The trial was prospectively registered in the China Registry of Clinical Trial (https://www.chictr.org.cn/index.html; ChiCTR2400079412) and is now complete.
Primary tuberculosis of the breast from mankweng hospital
Authors: Leso-Rangwato Leseilane Maureen , Bhuiyan Mirza M. Z. U. 
Published: January 2024

Object of study: To share our experience with a rare case of Primary Tuberculosis of Breast.
The problem to be solved: Tuberculosis of the breast is a rare type of extrapulmonary tuberculosis and usually affects young lactating multiparous women. It accounts for less than 0.1 % of all breast pathologies. Tuberculosis of the breast is often misdiagnosed. Therefore, a high index of suspicion is needed when evaluating cases of breast abscesses, fistulae, or mass.
Main scientific results: A case of a 27-year-old female with no known co-morbidities, HIV negative who presented to our Surgical Outpatient Department with a 1-year history of a painless left breast lump. No previous history of pulmonary tuberculosis was reported. Breasts ultrasonography indicated BIRADS (Breast Imaging-Reporting and Data System) V: lesion highly suspicious of malignancy. Histopathological analysis of the core biopsy showed features of a necrotizing granulomatous mastitis with adjacent fat necrosis. Ziehl-Neelsen stain was negative though histological results were worrisome of a mycobacterial infection. Patient responded well to antitubercular therapy as evidenced by lump regression, ulceration healed, peau d’orage currently resolved, and the overall size of the breast is going back to its normal state.
The area of practical use of research results: Family medicine physicians, Primary health care center, District level or regional level hospital.
An innovative technological product: a high index of suspicion tuberculosis is needed when evaluating cases of breast abscesses, fistulae, or mass. Awareness of this condition is important as it can clinically, and radiologically mimic breast carcinoma.
Scope of application of an innovative technological product: Family medicine physicians, Primary health care center.
Competência informacional com vistas à mulher em situação de violência
Authors: Neri Georginei Souza , Mota Francisca Rosaline Leite 
Published: January 2024

A violência contra a mulher é uma realidade mundial estabelecida nas desigualdades de gênero e perpetuada por discursos culturais e sociais. O acesso e uso de informações precisas e atualizadas sobre diferentes formas de violência são fundamentais para romper o ciclo de agressão e da falta de conhecimento sobre direitos e leis de proteção. Nesta perspectiva, é mister entender o comportamento informacional e fomentar a Competência Informacional das mulheres vítimas da violência de gênero. O presente artigo se propõe a tecer considerações sobre as deficiências sociais, políticas e operacionais existentes na esfera de amparo e proteção às mulheres vítimas de violência (s). Como resultado, propõe a construção de um modelo de rede pautado na intersecção mulher-informação-órgãos de apoio e proteção contra à(s) violência(s), fundamentada nas competências em informação de modo concomitante.
Association of Cystatin C Level with All-cause Mortality in Patients
with Liver Cirrhosis: A Meta-analysis
Authors: Wang Xiaoyan , Xu Wei , Yao Lin , Jie Yu , Gao Zhenjun , Fan Yu 
Published: January 2024

Background and Objective::
Blood cystatin C level has been introduced as a
promising biomarker to detect early kidney injury in cirrhotic patients. The purpose of
this meta-analysis was to investigate the association of blood cystatin C level with allcause
mortality in patients with liver cirrhosis.

Methods::
PubMed, ScienceDirect, and Embase databases were searched from the inception
to November 15, 2022. Observational studies evaluating the value of blood cystatin
C level in predicting all-cause mortality in patients with ACS were selected. The pooled
hazard risk (HR) with 95% confidence intervals (CI) was calculated using a random effect
model meta-analysis.

Results::
Twelve studies with 1983 cirrhotic patients were identified. The pooled adjusted
HR of all-cause mortality was 3.59 (95% CI 2.39-5.39) for the high versus low group
of cystatin C level. Stratified analysis by study design, characteristics of patients, geographical
region, sample size, and length of follow-up further supported the predictive
value elevated cystatin C level.

Conclusion::
Elevated cystatin C level was an independent predictor of poor survival in
patients with liver cirrhosis. Detection of blood cystatin C level may provide important
prognostic information in cirrhotic patients.
Identification of Crosstalk Genes between Lung Adenocarcinoma and Periodontitis
Authors: Wang Pengcheng , Yu Hui , Gao Xiaoli , Guo Ziyi , Zhang Zheng , Wang Zuomin 
Published: January 2024

Background:
Lung adenocarcinoma (LUAD) represents a significant global
health issue. Smoking contributes to the development of periodontitis and LUAD. The
connections between the two are still ambiguous.

Methods:
Based on RNA expression data from The Cancer Genome Atlas (TCGA) and
Gene Expression Omnibus (GEO) databases, differentially expressed genes (DEGs) in
Periodontitis and LUAD were collected. Protein-protein interaction (PPI) networks were
produced by mining genes intersecting with crossover DEGs. Genes in the subnetwork
and the top 15 genes of the topology score were defined as the crosstalk gene. Feature selection
and diagnostic model construction were conducted based on Recursive Feature
Elimination (RFE) and support vector machines (SVM). additionally, we analyzed the
immune cells and signaling pathways influenced by the crosstalk gene.

Results:
A total of 29 crossover DEGs between Periodontitis and LUAD were filtered,
with 20 genes interacting with them in the PPI network. Five subnetworks with similar
interaction patterns in the PPI network were detected. Based on the network topology
analysis, genes ranking in the top 15 were used to take the intersection with those genes
in the 5 subnetworks. Twelve intersecting genes were identified. Based on RFE and
SVM algorithms, FKBP11 and MMP13 were considered as the Crosstalk genes for both
Periodontitis and LUAD. The diagnostic model composed of FKBP11 and MMP13
showed excellent diagnostic potential. In addition, we found that FKBP11 and MMP13
influenced Macrophages, M1, T cells, CD8 activity, immune-related pathways, and cell
cycle pathways.

Conclusion:
We identified the crosstalk genes (FKBP11 and MMP13) between periodontitis
and LUAD. The two genes affected the comorbidity status between the two diseases
through immune cell activity.
Neuritin Alleviates Diabetic Retinopathy by Regulating Endoplasmic
Reticulum Stress in Rats
Authors: Wen Shu , Hu Meng , Chen Changzheng , Li Zhen , Liu Guoli 
Published: January 2024

Background:
Neuritin, a small-molecule neurotrophic factor, maintains neuronal cell
activity, inhibits apoptosis, promotes process growth, and regulates neural progenitor cell differentiation,
migration, and synaptic maturation. Neuritin helps retinal ganglion cells (RGCs) survive
optic nerve injury in rats and regenerate axons. However, the role of Neuritin in Diabetic retinopathy
(DR) is unclear.

Objective:
This study is intended to investigate the effect and mechanism of Neuritin in DR. For
this purpose, we established DR rat models and injected Neuritin into them. This study provides a
potential treatment for diabetic retinopathy.

Methods:
The rat model of DR was established by streptozotocin (STZ) injection, and the effect
of Neuritin on DR was detected by intravitreal injection. Histological analysis was performed by
H&E and TUNEL methods. The mRNA and protein expressions of endoplasmic reticulum stress
(ERS) pathway-related transcription factors were detected by qRT-PCR and western blot. The
blood-retinal barrier (BRB) function was assessed using the patch-clamp technique and Evans blue
leakage assay.

Results:
Neuritin significantly improved the retinal structure, restrained the apoptosis of retinal
cells, and protected the normal function of BRB in DR model rats. Mechanistically, Neuritin may
function by inhibiting the expression of GRP78, ASK1, Caspase-12, VEGF, and so on.

Conclusion:
Our results indicate that Neuritin alleviates retinal damage in DR rats via the inactive
endoplasmic reticulum pathway. Our study provides a potential treatment for DR.
Role of Ubiquitin-specific Proteases in Hepatocellular Carcinoma
Pathogenesis
Authors: Zhang Xinwen , Jin Jiamin , Cong Jiacheng , Chen Siqi , Wang Ting , Gao Bin , Huang Guanlin , Huang Zhiqiang , Zhang Juzheng , Wang Zhenran , Yang Jinfeng 
Published: January 2024

Abstract:
Signaling pathways in hepatocellular carcinoma are primarily mediated by the phosphorylation
and ubiquitination of post-translational proteins. In mammalian cells, ubiquitin-specific
proteases (USPs) account for the majority of protein deubiquitination activities. In addition to transcriptional
and post-translational regulation, ubiquitination plays an important role in the regulation
of key proteins. There is a possibility that altered biological processes may lead to serious human
diseases, including cancer. Recent studies have revealed the role of USPs in hepatocellular
carcinoma tumorigenesis. The purpose of this review is to summarize the involvement of this
class of enzymes in the regulation of cell signaling in hepatocellular carcinoma and the therapeutic
development of inhibitors that target USPs, which may lead to novel therapies to treat hepatocellular
carcinoma.
Deteriorating Pulmonary Functions in Patients with Rheumatoid
Arthritis- A Pilot Study from South India
Authors: Shanmugavaradharajan Vijayabaskaran , NT Rajesh , R Divya , Vasudevan Damodaran 
Published: January 2024

Background and Objective:
Pulmonary involvement is a common extra-articular manifestation
of rheumatoid arthritis (RA). The present study attempts to highlight the extent of involvement
by assessing lung function using pulmonary function tests (PFTs) in patients with RA.

Methods:
This pilot study involved 30 patients with RA and an equal number of age- and sexmatched
healthy controls. All the study participants were subjected to spirometry and in RA patients,
the test was repeated after 30 minutes of administering 400 mcg of salbutamol. PFT values
of the controls and the pre and post-values of cases like forced vital capacity (FVC), forced expiratory
volume in the first second (FEV1), Percentage of forced expiratory volume in the first second
(FEV1%), forced expiratory flow at 25% to 75% of the lung volume (FEF25-75%) and peak expiratory
flow rate (PEFR) were recorded. Independent sample t-test or Mann-Whitney U test were
used for comparisons. The pre- and post-values of PFT were compared using paired t-test,
Welsch’s test, or Wilcoxon tests. (p ≤ 0.05 implied statistical significance).

Results:
PFT variables were significantly lower among patients with RA compared with controls
(p<0.05). A significant negative correlation of FEF25%-75% and PEFR with BMI in obese patients
(BMI >23) and FVC, FEV1, and PEFR significantly lower in post-menopausal women (p <
0.05) was seen.

Conclusion:
Based on the pilot study findings, patients in south India with RA could manifest decreased
pulmonary functions. Obese patients and post-menopausal females with RA could be at a
higher risk, and the administration of nebulized salbutamol could improve pulmonary functions.
Acute Pancreatitis Obstructed by a “Stone” as the First Manifestation of
Eosinophilic Gastroenteritis in AIDS: A Case Report
Authors: Zhang Fulong , Xu Jing , Zhu Yuandong , Chen Shurong , Shi Yan , Zhan Zongyuan , Zhou Jingwei , Jiang Yuhong , Wang Hai 
Published: January 2024

Background::
Acquired immune deficiency syndrome (AIDS) associated with eosinophilic gastroenteritis is rare. We report a case of duodenal “stone” inducing
acute pancreatitis with eosinophilic gastroduodenitis in an AIDS patient.

Case Summary::
A 73-year-old female AIDS patient came to the hospital with recurrent abdominal pain for 20 days. Computed tomography (CT) showed
pancreatitis with exudation and a high-density shadow under the gastric antrum. Gastroscopy showed that the descending part of the duodenum
was blocked by a “stone”. The mucosa of the duodenum was rough, and a red polyp was found on the gastric body. The pathology result was
chronic inflammation with eosinophilic granulocytes in the duodenal mucosa and gastric body polyp.

Conclusion::
When AIDS patients suffer acute pancreatitis, the possibility of eosinophilic gastroenteritis needs to be considered to enable the patient to accept
timely treatment.
Quantitative Analysis of the Impact of Different Delivery Modes on Cervical
Elasticity Based on Real-time Shear Wave Imaging Technology and Artificial
Intelligence
Authors: Song Xue , Liu Cun , Chen Shuai 
Published: January 2024

Background::
Real-time shear wave elastography (SWE) has emerged as a useful imaging modality for detecting the lesion location of various diseases,
including cervical diseases.

Objectives::
In this paper, the SWE was used to quantitatively determine the tissue hardness of the internal and external orifice of cervix (IOC &amp;amp;amp; EOC), and to relatively objectively analyze the impact of different production methods on the hardness of the cervical tissue.

Methods::
A total of 48 patients were selected, and they were divided into three groups according to different production methods: control group (16 cases),
cesarean section group (16 cases), and spontaneous delivery group (16 cases). Artificial intelligence has also been incorporated into this work. A
deep flexible neural tree model and a new set of FNT models were proposed to assist in classifying cervical physical data in different states. The
physical data was extracted as the features, and the different states were considered as category labels.

Results::
There was no statistically significant difference in the elasticity of the IOC and the EOC between the groups; the difference in the elasticity of the IOC and the EOC of each group was statistically significant. The classification results kept correspondence with statistical analysis results. The hardness of the EOC is generally lower than that of the IOC, and no significant difference occurred in the hardness of the IOC and the EOC between three groups.

Conclusion::
There is no significant difference in the hardness of cervical elasticity between different delivery modes.
Integrated Bioinformatics Analysis and Target Drug Prediction of Inflammatory Bowel Disease Co-existent Diabetes Mellitus
Authors: Yang Lili , Wang Ning , Wang Yutong , Li Wen , Kong Ziyang , Zhang Bin , Bian Yaoyao 
Published: January 2024

Introduction:
Inflammatory bowel disease (IBD) has become one of the public problems
worldwide and its incidence rate is increasing year by year. Its concomitant disease i.e.
diabetes mellitus (DM) has attracted more and more attention due to DM altering the progression
of IBD and leading to long periods of intermittent recurrence and deterioration. The common
mechanism and potential target drug of IBD with comorbid chronic conditions of DM were
explored.

Methods:
Gene expression profile data were downloaded from the Gene Expression Omnibus
(GEO) public database. The differentially expressed genes (DEGs) were identified by R software.
GO annotation and pathway enrichment were performed, a protein-protein interaction
(PPI) network was constructed, associated lncRNAs were predicted and drug prediction targeting
key genes was made. Additionally, the regulatory network among core genes, associated
pathways, and predicted lncRNA in IBD with coexistent DM were visualized.

Results:
We identified the critical gene MMP3 with lncRNA CDKN2BAS involved in the
PPAR pathway, which uncovered the underlying regulatory mechanism of IBD with coexistent
DM. We also predicted the potential therapeutic compound ZINC05905909 acting on MMP3.

Conclusion:
Our findings revealed the regulatory mechanism chain of critical gene MMP3,
lncRNA CDKN2BAS, and PPAR pathway and provided potential therapeutic compound
ZINC05905909 for drug therapy to treat comorbid IBD DM.
Evaluation of Phytochemicals, Antioxidants, and Antidiabetic Activity of
Nitophyllum marginale by Using Analytical Approaches
Authors: Malhotra Rohit , Cojandaraj Louis 
Published: January 2024

Background:
Nitophyllum marginale holds potential for medical applications due to its
bioactive compounds, making it promising for developing new therapeutic interventions. Our study
aims to evaluate the bioactivity of Nitophyllum marginale extracts obtained using methanol and
chloroform solvents. We focus on analyzing the phytochemical profile, antioxidant activity, and antidiabetic
potential of seaweed extract in this study. By examining the medicinal properties
of Nitophyllum marginale, we aim to explore the therapeutic bioactivity potentiality and its prime
role in improvising and searching for potential alternatives for seizing Diabetes mellitus.

Materials and Methods:
The antioxidant activity of Nitophyllum marginale was evaluated using
ABTS, DPPH, nitric oxide, lipid peroxidation, and hydrogen peroxide assays. Additionally, alphaglucosidase
inhibition tests were conducted to evaluate the potential as an antidiabetic agent.

Results:
The study revealed that extracts from Nitophyllum marginale contain antioxidants that protect
cells from oxidative stress. These extracts also contain bioactive compounds like alkaloids, flavonoids,
phenols, saponins, and carbohydrates. These compounds work together to provide antioxidant
benefits. Additionally, the extracts showed activity against alpha-glucosidase, which is vital for
managing blood sugar levels.

Conclusion::
These results emphasize the existence of bioactive metabolites exhibiting phytochemicals,
antioxidants, and antidiabetic activities obtained from the extract using chloroform and methanol
solvents. These findings suggest the potential of Nitophyllum marginale extracts as a natural
reservoir of antioxidants and antidiabetic agents.
Production of Nattokinase from Bacillus amyloliquefaciens MRS18: A
Bacterial Strain Isolated from Fermented Beans
Authors: Coutinho Simran B. , Shirodkar Rutuja R. , Kanjirakkandy Anju , Arulmozhi Vijayaganapathi , Vaithilingam Mohanasrinivasan , Chandrasekaran Subathra D. 
Published: January 2024

Background::
Nattokinase (NK) is a naturally occurring fibrinolytic protease enzyme
obtained from the traditional Japanese food called Natto and has several uses in the pharmaceutical
and medical industries. Nowadays, the most often used thrombolytic agent in the clinical
field is NK, in part because it is less expensive than other thrombolytic medicines.

Objective::
The objective of this study is to investigate the screening, isolation and characterization
of the NK enzyme-producing Bacillus strain from fermented Soya beans.

Methods::
The sample of fermented soya beans were tested for the presence of fibrinolytic protease-
producing bacteria, followed by the screening, extraction, characterization and clot lysis assays.

Results::
A total of three isolates were screened for caseinolytic activities by casein hydrolysis
assay. Out of those isolates, MRS18 was found to be potent in producing the enzyme proteinase.
To determine the taxonomy and phylogeny of these isolates, biochemical and molecular characterization
has been carried out. Bacillus amyloliquefaciens MRS18 has been found with the highest
caseinolytic activity. The clot lysing ability of the potent strain Bacillus amyloliquefaciens
was found to be 61.7% after 120 min, and on further purification, by ammonium sulphate precipitation
method, the lysis percentage was found to be 656% after 120 min.

Conclusion::
From the results of the present study, we concluded that Bacillus amyloliquefaciens
isolated from the fermented soya beans produced an NK enzyme that exhibits immense
potential to lyse blood clots.
Improved Thermal Performance and Distillate of Conventional Solar Still
via Copper Plate, Phase Change Material and CuO Nanoparticles
Authors: Kumaravel Subramanian , Nagaraj Meenakshi Sunadaram , Bharathiraja Govindarajan 
Published: January 2024

Background::
The world is currently facing a growing concern regarding freshwater scarcity,
which has arisen as a result of a complex interplay of various factors. Renewable energy-powered
water desalination is a feasible solution to address freshwater scarcity.

Methods::
This patent study presents a comprehensive investigation of the performance of a conventional
solar still (CSS) and its modified versions, such as a still with copper plates, a still with PCM
and a still with PCM and 3 wt% CuO nanoparticles blend. The experiments were carried out concurrently
under identical circumstances for the CSS and the proposed stills. Prior to usage, the CuO nanoparticles
and their blend with PCM were characterized through various analyses

Results::
The investigation showcased the copper plate attached solar still with 3 wt% CuO nanoparticles
blended with PCM significantly improved the distillate production, achieving approximately 6.85
kg/m2/day. This represents an increment of approximately 23.42% compared to the still with copper
plate and PCM and 69.14% related to the CSS.

Conclusion::
Moreover, the solar still with 3 wt% CuO nanoparticles blended with PCM demonstrated
a thermal efficiency of 74.23% and an exergy efficiency of 9.75%. The production cost of distillate
for all four stills remained at $0.03 per kg. These findings highlight the effectiveness of the proposed
copper plate attached solar still with 3 wt% CuO nanoparticles blended with PCM as a viable method
for producing potable water.