bluuebunny/crossref_metadata_2025_split huggingface dataset:
Quantifying AMPARs with 99mTc-omberacetam: a novel diagnostic radiotracer for ischemic stroke
Authors: Azhari Hala F. , Hashem Abdelgawad M. 
Published: November 2023

AbstractSynaptic trafficking of α-amino-3-hydroxy-5-methyl-4-isoxazole propionic acid receptors (AMPARs) is thought to cause excitotoxicity brain ischemia. However, given the current inability to quantify AMPARs density in live human brains, clinical translation has been limited. In this study, in vivo and in vitro experiments were conducted to evaluate the factors affecting omberacetam drug labeling with technetium-99m as a potential radiotracer of AMPARs in brain imaging. Healthy Swiss albino mice (adult male; n = 25; weight 25–30 g; age 10–14 weeks) underwent Shimadzu modeling, followed by a random intravenous injection of 99mTc-omberacetam (0.2 mL, 3.7 MBq), which was subsequently radiosynthesized in the brain-targeting AMPARs utilizing a single-photon emission computed tomography nuclear neuroimaging. Under optimal conditions, 99mTc-omberacetam with a highest radiochemical purity of 98.9% was obtained with an optimum binding (energy = − 82.3 kcal/mol) to brain AMPARs and was stable in human serum for > 24 h. A high brain uptake was noted within a time window of 15–60 min. At 5 min, this signal uptake was 8.9 ± 0.1% of the injected dose per gram (ID/g), crossing the blood–brain barrier and surpassing the uptake of commercially available brain perfusion imaging agents such as 125I-iododomperidone (5.6% ID/g at 5 min) in mice, 99mTc-HMPAO (2.25% ID/g at 2 min) in rats, and 99mTc-ECD (4.7% ID/g at 6 h) in humans. This study is the first to show the feasibility of 99mTc-omberacetam radiotracing for human brain imaging. This could be a novel diagnostic and therapeutic neuroprotective target for the hyperacute stage of ischemic stroke.
Graphical abstract
The meaning and form of onomatopoeias in Tjwao
Authors: Andrason Alexander , Phiri Admire , Fehn Anne-Maria 
Published: November 2023

AbstractThe present article analyzes the meaning and form of onomatopoeias in Tjwao, a Khoe-Kwadi (Kalahari Khoe) language. Making use of a prototype approach to categorization, a corpus of 113 onomatopoeic lexemes were tested for their compliance with the semantic, phonetic, and morphological features associated with the prototype of onomatopoeias in scholarly literature. The evidence demonstrates that Tjwao onomatopoeias tend to instantiate the prototype fully. This signifies, in turn, that, as far as their phonetics and morphology are concerned, Tjwao onomatopoeias tend to be extra-systematic.
Tracing the evolution of the gender of “COVID-19” in the French of three continents: A traditional and social media study
Authors: Dow Michael , Drouin Patrick 
Published: November 2023

AbstractIn this article, we document the gender of the noun “COVID-19” in a database of more than 76,000 tweets and in traditional media (approximately 500,000 articles) in French as spoken in Africa, (North) America and Europe. We find that North American media comply near-categorically with the recommendations of the feminine by the World Health Organization and local linguistic authorities in March 2020. The majority of North American tweets follow suit soon after. The African data show an increase of articles and tweets adopting the feminine after the Académie française's recommendation in May 2020. Finally, the feminine is negligible in the European data. We argue that among the factors at play are dialect-specific differences in French gender and loanword adaptation; the complex relationship among linguistic authorities, the public, and local media; and the relative delay in the Académie française's recommendation of the feminine.
Acquisition of English relative clauses by native speakers of Kurdish Sorani
Authors: Bahar Golpar 
Published: November 2023

AbstractThe present study investigates several linguistic factors that might be determinants of differences in the ease of acquisition of relative clauses (RCs) in L2 contexts, using the acquisition of English relative clauses by Kurdish Sorani native speakers. The analysis of 1440 subject and object RCs formed by Kurdish Sorani-speaking learners of English in a sentence combination task and a sentence translation task indicates that the syntactic functions of the noun phrase (NP) relativized in the RC, the position of the RC in the matrix clause (whether centre- or right-embedded), and the properties of RCs in L1 affect the acquisition and the formation of RCs in L2. The study also provides evidence that the syntactic functions of the relativized NP in the matrix clause, and the consistency/inconsistency of word orders in L1 and L2 do not influence the acquisition of RCs in L2.
Acquisition of kind-reference by Arabic, Chinese, and Turkish L2 learners of English
Authors: Köylü Yilmaz 
Published: November 2023

AbstractThis study examines the acquisition of kind-referring expressions such as The dodo is extinct. The objective is to investigate whether second language (L2) learners’ acquisition of nominal number marking and articles expressing kind-reference in English is affected by their first language (L1), their L2 proficiency in English, or the syntactic position of the kind-referring noun phrase (NP). L2 learners of English with Arabic, Chinese, and Turkish L1 backgrounds and a control group of native English speakers (NSs) participated in the study. The results from a Fill in the Gaps Task (FGT) and an Acceptability Judgment Task (AJT) demonstrated that L2 learners were more successful in their production and acceptability judgments when the expression of kind-reference in the target language was similar to that in their L1. The results also showed non-facilitative L1 transfer in the domain of bare singulars, as well as a positive effect of higher L2 proficiency on kind-referring NPs. Finally, the study revealed a subject/object asymmetry in the acquisition of kind-referring NPs in L2 English.
A normative model for Bayesian combination of subjective probability estimates
Authors: Trick Susanne , Rothkopf Constantin A. , Jäkel Frank 
Published: November 2023

AbstractCombining experts’ subjective probability estimates is a fundamental task with broad applicability in domains ranging from finance to public health. However, it is still an open question how to combine such estimates optimally. Since the beta distribution is a common choice for modeling uncertainty about probabilities, here we propose a family of normative Bayesian models for aggregating probability estimates based on beta distributions. We systematically derive and compare different variants, including hierarchical and non-hierarchical as well as asymmetric and symmetric beta fusion models. Using these models, we show how the beta calibration function naturally arises in this normative framework and how it is related to the widely used Linear-in-Log-Odds calibration function. For evaluation, we provide the new Knowledge Test Confidence data set consisting of subjective probability estimates of 85 forecasters on 180 queries. On this and another data set, we show that the hierarchical symmetric beta fusion model performs best of all beta fusion models and outperforms related Bayesian fusion models in terms of mean absolute error.
Working memory capacity and the risky-choice framing effect: A preregistered replication and extension of Corbin et al. ()
Authors: Bogdanov Boris , Corbin Jonathan , Dobreva Sabina , McElroy Todd , Rachev Nikolay R. 
Published: November 2023

Abstract
While working memory capacity is associated with superior performance on a number of tasks, could it paradoxically sometimes be associated with suboptimal performance? Corbin et al. (2010, Judgment and Decision Making 5(2), 110–115) found that, in a between-subjects design, higher WMC is associated with a larger risky-choice framing effect, traditionally conceived of as a departure from rational principles. Such surprising findings are of potentially great theoretical importance; yet the original study was underpowered. In this registered report, we aimed to replicate and extend the original findings, by conducting an online experiment among 425 North Americans. To extend the findings beyond the specific single tasks used in the original study, we used three WMC tasks with different processing components and six framing problems involving human lives. In a close replication, the frame significantly interacted with neither the Ospan short absolute score nor the Ospan short partial score in predicting ratings on the disease-framing problem. Similarly, in an extended replication, a composite WMC score did not significantly interact with the frame in predicting ratings on three framing problems involving human lives. The Bayes factors showed that the data were 3 to 10 times more likely under the null hypothesis of no interaction between WMC and frame. Taken together, these findings show an absence of association between the between-subjects risky-choice framing effect and WMC. This outcome is compatible with four out of the six theoretical accounts we considered, and is uniquely predicted by the default-interventionist dual-process account and the pragmatic inference account. Further research can more rigorously pit conflicting predictions of these accounts against each other.
Association between micronutrients intake and metabolic-associated fatty liver disease: a cross-sectional study based on the National Health and Nutrition Examination Survey
Authors: Hou Jun-zhen , Wu Qi-wei , Zhang Li 
Published: November 2023

Abstract
Metabolic-associated fatty liver disease (MAFLD) has been proposed to replace the term non-alcoholic fatty liver disease (NAFLD) in 2020. The association between micronutrients and MAFLD has not been reported. Therefore, this study aims to explore the association between micronutrients intake and MAFLD. This was a cross-section study based on the National Health and Nutrition Examination Survey (NHANES). The dietary intake of copper, zinc, iron, and selenium was evaluated using the 24-h dietary recall interview. Logistic regression analysis was used to explore the association between micronutrients and MAFLD, and the results were shown as odds ratio (OR) with 95 % confidence intervals (CIs). A total of 5976 participants were finally included for analysis, with 3437 participants in the MAFLD group. After adjusting potential confounders, copper intake at quartile Q3 (OR = 0⋅68, 95 % CI 0⋅50, 0⋅93) and Q4 (OR = 0⋅60, 95 % CI 0⋅45, 0⋅80) was found to be associated with lower odds of MAFLD. Iron intake at Q2 (OR = 0⋅64, 95 % CI 0⋅45, 0⋅92) and Q3 (OR = 0⋅61, 95 % CI 0⋅41, 0⋅91) was associated with the lower odds of MAFLD. Our findings found that high intake of copper and adequate intake of iron were associated with MAFLD, which may provide guidance for the management of MAFLD.
Effect of substrate salinity and pH on life history traits of the bluetongue virus vectorCulicoides peregrinus
Authors: Banerjee Paramita , Sarkar Ankita , Mazumdar Abhijit 
Published: November 2023

AbstractHabitat selection ofCulicoidesspp. (Diptera: Ceratopogonidae) is influenced by the physicochemical factors such as temperature, pH, salinity, moisture, conductivity, organic and inorganic compounds of substrates. These factors determine the life history traits of the vectors. We studied the influence of substrate salinity (0–40 parts per thousand, ppt) and pH (pH 1–13) on oviposition, egg hatching, larval survivability, and adult emergence ofCulicoides peregrinusKieffer under laboratory conditions. Most eggs (80.74%) were laid in 0 ppt and 95% in pH 7 but lowered with increased salinity and pH levels. It was observed that the females did not lay eggs in 30 ppt to 40 ppt salinity; pH 1 and pH 13 but interestingly up to 95% of the eggs were retained within the abdomen. Little effect of salinity and pH on egg hatching was observed up to 5 ppt and 10 ppt except at the extreme values of 40 ppt and pH 1, pH 13. Pupation did not occur in rearing plates with high salinities, 30 ppt and 40 ppt, although the few eggs hatched when exposed to such salinity. In low salinity (0 to 2 ppt), occurrence of adult emergence was more and then decreased with increasing salinity. Maximum emergence was seen when the rearing media was alkaline. This study deals with the suitability of breeding substrate ofC. peregrinuswhen exposed to salinity and pH ranges. Our study suggests the ambient salinity and pH ranges to be maintained during laboratory rearing of this vector species.
Political Polarisation and the Constitutional Crisis in Israel
Authors: Porat Iddo 
Published: November 2023

AbstractThe article aims to further the understanding of the current constitutional crisis in Israel through the lens of political polarisation. Israel, like other countries around the world, is experiencing a substantial increase in political polarisation. Recent data shows that since 2009 affective polarisation (the extent to which individuals have negative feelings towards members of the opposing party or group and positive feelings towards their own party or group) has risen by 180 per cent. The article discusses the various phenomena associated with an increase in polarisation and the problems it raises, traces the reasons for the increase in polarisation in Israel, and argues that polarisation has played an important role in creating the conflict between the current government and the Supreme Court, and in making it so intense and intractable.
Weather indices during reproductive phase explain wheat yield variability
Authors: Zeleke Ketema Tilahun , Anwar Muhuddin , Emebiri Livinus , Luckett David 
Published: November 2023

AbstractWhen water and nutrients are not limiting, and pests and disease are effectively controlled, crop growth and yield is determined by weather conditions such as temperature and solar radiation. To determine the relationship between weather indices and crop yield, multiple wheat varieties were sown at two sowing times, for five sowing seasons and at two locations. The following weather indices around the 50% anthesis stage were recorded and analysed: mean temperature (Tmean), maximum temperature (Tmax), number of days with temperature >30°C (T30), vapour pressure deficit (VPD), photosynthetically active radiation, photothermal quotient (PQ) and photothermal quotient corrected for vapour pressure deficit (PQvpd). Overall, for every 1°C rise in temperature, crop yield decreased by 370 kg/ha. For every 1°C rise in temperature, normal sowing window yield decreased by 360 kg/ha while late-sown wheat yield decreased by 640 kg/ha. Correlation analysis was conducted between the weather indices and grain number, grain yield and grain protein. There was a significant positive correlation between PQ and PQvpd and grain number and grain yield. There was a significant negative correlation between Tmean, Tmax, T30 and VPD and grain number and grain yield. Grain protein content showed a positive correlation with maximum air temperature and a negative correlation with the weather indices PQ and PQvpd. PQ and PQvpd can be used to predict grain number and grain yield potential. This study showed that grain number and grain yield predicted using PQ and PQvpd are more reliable than using temperature and radiation individually.
Protective factors for children with autism spectrum disorder during COVID-19-related strict lockdowns: a Shanghai autism early developmental cohort study
Authors: Zhang Lingli , Ren Tai , He Hua , Huang Like , Huang Runqi , Xu Yixiang , Zhou Li , Tan Hangyu , Chen Jingyu , Wu Danping , Yang Hanshu , Zhang Haotian , Yu Juehua , Du Xiujuan , Dai Yuan , Pu Yiwei , Li Chunbo , Wang Xiang , Shi Shenxun , Sahakian Barbara J. , Luo Qiang , Li Fei 
Published: November 2023

AbstractBackgroundCOVID-19 lockdowns increased the risk of mental health problems, especially for children with autism spectrum disorder (ASD). However, despite its importance, little is known about the protective factors for ASD children during the lockdowns.MethodsBased on the Shanghai Autism Early Developmental Cohort, 188 ASD children with two visits before and after the strict Omicron lockdown were included; 85 children were lockdown-free, while 52 and 51 children were under the longer and the shorter durations of strict lockdown, respectively. We tested the association of the lockdown group with the clinical improvement and also the modulation effects of parent/family-related factors on this association by linear regression/mixed-effect models. Within the social brain structures, we examined the voxel-wise interaction between the grey matter volume and the identified modulation effects.ResultsCompared with the lockdown-free group, the ASD children experienced the longer duration of strict lockdown had less clinical improvement (β = 0.49, 95% confidence interval (CI) [0.19–0.79], p = 0.001) and this difference was greatest for social cognition (2.62 [0.94–4.30], p = 0.002). We found that this association was modulated by parental agreeableness in a protective way (−0.11 [−0.17 to −0.05], p = 0.002). This protective effect was enhanced in the ASD children with larger grey matter volumes in the brain's mentalizing network, including the temporal pole, the medial superior frontal gyrus, and the superior temporal gyrus.ConclusionsThis longitudinal neuroimaging cohort study identified that the parental agreeableness interacting with the ASD children's social brain development reduced the negative impact on clinical symptoms during the strict lockdown.
Pretreatment cognitive performance is associated with differential self-harm outcomes in 6 v. 12-months of dialectical behavior therapy for borderline personality disorder
Authors: Traynor Jenna M. , McMain Shelley , Chapman Alexander L. , Kuo Janice , Labrish Cathy , Ruocco Anthony C. 
Published: November 2023

AbstractBackgroundRecent findings suggest that brief dialectical behavior therapy (DBT) for borderline personality disorder is effective for reducing self-harm, but it remains unknown which patients are likely to improve in brief v. 12 months of DBT. Research is needed to identify patient characteristics that moderate outcomes. Here, we characterized changes in cognition across brief DBT (DBT-6) v. a standard 12-month course (DBT-12) and examined whether cognition predicted self-harm outcomes in each arm.MethodsIn this secondary analysis of 240 participants in the FASTER study (NCT02387736), cognitive measures were administered at pre-treatment, after 6 months, and at 12 months. Self-harm was assessed from pre-treatment to 2-year follow-up. Multilevel models characterized changes in cognition across treatment. Generalized estimating equations examined whether pre-treatment cognitive performance predicted self-harm outcomes in each arm.ResultsCognitive performance improved in both arms after 6 months of treatment, with no between-arm differences at 12-months. Pre-treatment inhibitory control was associated with different self-harm outcomes in DBT-6 v. DBT-12. For participants with average inhibitory control, self-harm outcomes were significantly better when assigned to DBT-12, relative to DBT-6, at 9–18 months after initiating treatment. In contrast, participants with poor inhibitory control showed better self-harm outcomes when assigned to brief DBT-6 v. DBT-12, at 12–24 months after initiating treatment.ConclusionsThis work represents an initial step toward an improved understanding of patient profiles that are best suited to briefer v. standard 12 months of DBT, but observed effects should be replicated in a waitlist-controlled study to confirm that they were treatment-specific.
Zeros, chaotic ratios and the computational complexity of approximating the independence polynomial
Authors: DE BOER DAVID , BUYS PJOTR , GUERINI LORENZO , PETERS HAN , REGTS GUUS 
Published: November 2023

AbstractThe independence polynomial originates in statistical physics as the partition function of the hard-core model. The location of the complex zeros of the polynomial is related to phase transitions, and plays an important role in the design of efficient algorithms to approximately compute evaluations of the polynomial.In this paper we directly relate the location of the complex zeros of the independence polynomial to computational hardness of approximating evaluations of the independence polynomial. We do this by moreover relating the location of zeros to chaotic behaviour of a naturally associated family of rational functions; the occupation ratios.
Two early layers of Sanctus melodies
Authors: PFISTERER ANDREAS 
Published: November 2023

ABSTRACTThis article examines Sanctus melodies from the tenth and eleventh centuries with special attention to the division of the first verbal phrase. The melodies with circulation in all regions of the Roman rite fall into two groups, an earlier one with ternary division and a later one with binary division. This picture is further enriched by the analysis of melodies connected in some way with these widespread melodies, by the simple melodies of the Sundays and weekdays and by an overview over northern French melodies of the eleventh and twelfth centuries.
Change in the composition of primary metabolites, minerals and secondary metabolites in natural Ziziphus lotus (L. Desf.) wild fruits under environmental variations
Authors: Dahlia Fatima , Barouagui Soria , Mahieddine Sarah , Salah Omar , Drici Khaled , Attil Mokhtar , Heroual Mohamed Amine , Harrouche Ilyes , Doukani Koula 
Published: November 2023

AbstractZiziphus lotus is an underappreciated natural genetic resource widespread in Algeria. This study aimed to compare the fruit phytochemical composition of nine populations of Z. lotus from different areas to highlight its diversity. Fruits were harvested from the semiarid, dry steppe and Saharan stages. Primary and secondary metabolites and minerals contents were determined. Significant variations in the fruit phytochemical composition between populations of Z. lotus and between pulp and seeds were recorded. Z. lotus is dry fruit with 8.768 ± 0.449 to 13.468 ± 1.303% water in pulp and 6.7 to 12.12% in seeds. Significantly higher values were recorded in the fruit pulp for sugar (35.25 to 48.87%), phosphorus (63.114 to 155.269 mg 100−1g), sodium (34.8 to 56.91 ppm), calcium (91.78 to 382.69 ppm), β-carotene (36.4 to 46 μg g−1), lycopene (59.15 to 100.25 μg g−1) and chlorophyll a (3.6 to 7.2 μg g−1) contents. Seeds had much higher protein (8.37 to 27.75%), lipid (35.39 to 48.01%), potassium (125.874 to 325.408 mg. 100−1 g), polyphenol (439.465 to 1349.46 mg.GAE.100 g−1), flavonoid (83.908 to 98.259 mg.QE.100 g−1), tannins (55.268 to 277.94 mg.GAE.100 g−1) and chlorophyll b (11.2 to 30.4 μg g−1) contents. Bougtob, Boghar and Mougheul populations had higher primary metabolites and mineral values. Oued Nougued, Maarif and Mougheul populations were the richest in phenolic compounds. Oued Nougued, Maarif and Mougheul populations had more liposoluble pigments. This research is the beginning of investigating the variety of Z. lotus as phylogenetic sources. Further comparative investigations over a larger distribution region and further study of variations in the composition in fruit composition using GC-MS are needed.