bluuebunny/crossref_metadata_2025_split huggingface dataset:
The female self‐advocacy in Cancer Survivorship scale is a psychometrically sound measure of self‐advocacy in male cancer survivors
Authors: Thomas Teresa Hagan , Scott Paul W. , Nilsen Marci Lee , Lee Jiyeon , McCarthy Mary Ella , Harris Alexandria , Johnson Jonas , Donovan Heidi S. 
Published: December 2023

AbstractObjectiveTo develop and psychometrically evaluate an adapted version of the Female Self‐Advocacy in Cancer Survivorship (FSACS) Scale in men with a history of cancer.MethodsThis psychometric instrument development and validation study used a two‐phase approach to first adapt the FSACS Scale items to reflect the experience of men with a history of cancer and then evaluate the psychometric properties of the adapted scale compared to the original FSACS Scale. The study was conducted from December 2018 through April 2022 through cancer clinics, patient registries, and national advocacy organizations. We evaluated scale reliability and validity using reliability coefficients, exploratory and confirmatory factor analyses, and item analyses to determine a final set of scale items.ResultsItem responses from N = 171 men with a history of cancer were evaluated to determine scale validity. After removing poor‐performing items based on item‐level analyses, factor analyses confirmed that a 3‐factor structure of both the adapted and original FSACS Scale best fit the scale. The 10 new items did not outperform the original 20‐item scale and were therefore excluded from the final scale. The final 20‐item scale explained 87.94% of item variance and subscale's Cronbach α varied from 0.65 to 0.86.ConclusionThe SACS Scale can be used in research and clinical contexts to assess the propensity of men and women to get their needs, values, and priorities met in the face of a challenge.
MXene‐Based Capacitive Deionization–Strong Competitor Among Faradaic Electrode Systems: Current Status and Future Perspectives
Authors: Dubey Prashant 
Published: December 2023

AbstractCapacitive deionization (CDI) of brackish water is emerging as a sustainable and energy efficient desalination processes to mitigate the excessive demand of freshwater. Despite that the porous carbon is prime choice in the conventional CDI; its electrostatic interaction‐based limited salt adsorption capacity (SAC, up to 25 mg g−1) has driven the research interest to explore various Faradaic electrodes for attaining maximum SAC (>100 mg g−1) in supplementation with the other desalination metrics. MXene is one of the newly discovered intercalation‐type pseudocapacitive nanostructures, which promised an excellent desalination performance due to its intriguing properties, such as tuneable interlayer spacing, high electrical conductivity, hydrophilicity, and structural integrity. Furthermore, its compositing/heterostructuring with other electro‐active components significantly improves the desalination activity. This article provides a systematic overview of the MXene‐based electrodes utilized in CDI along with the one‐to‐one comparison with other Faradaic systems. Materials design, structure, cell architecture, desalination metrics‐based performance evaluation, and underlying driving forces behind the salty ions removal activity are the main emphasis of discussion to realize MXene‐based efficient CDI desalination. Lastly, the key issues and perspectives of MXene‐based electrode systems are put forward towards new developments and real time implication.
Modifications of 4‐Amino‐substituted 5‐Phenyl‐3‐(trifluoromethyl)pyrazoles for the Development of New Analgesics
Authors: Shchegolkov Evgeny V. , Perminova Anastasia N. , Malkova Natalia A. , Kushch Svetlana O. , Burgart Yanina V. , Triandafilova Galina A. , Solodnikov Sergey Yu. , Krasnykh Olga P. , Saloutin Victor I. 
Published: December 2023

AbstractTo develop the new analgesics, different approaches to the modification of 4‐amino‐5‐phenyl‐3‐(trifluoromethyl)pyrazoles were proposed. A series of 4‐(het)arylimino‐3‐(trifluoromethyl)‐5‐phenylpyrazoles, existing as the E‐isomer, was synthesized by condensation of the 4‐aminopyrazoles with various aldehydes. Methylation of the initial substrates occurred at the NH2 group, while alkylation with bromobutyl was successfully carried out only for NH‐pyrazole to yield 3‐ and 5‐CF3‐isomeric N‐butyl‐substituted pyrazoles. The addition of phenylisothiocyanate to 4‐aminopyrazoles allowed us to introduce a thiourea fragment into their structure. According to computer calculations, all derivatives of aminopyrazoles have an acceptable ADME profile. Using the “hot plate” test in vivo, the analgesic activity of a number of the synthesized compounds was evaluated. Introducing the phenylmethanimine fragment allows us to obtain 1‐phenyl‐N‐(5‐phenyl‐3‐(trifluoromethyl)pyrazol‐4‐yl)methan‐imine as the lead compound with the analgesic activity in 1.4–2.2 times more than effect of the initial 4‐aminopyrazole, diclofenac and metamizole. In addition, the lead compound had low acute toxicity.
Molecular Docking Studies of Boron‐Containing Compounds as Dual Inhibitors of SARS‐Cov‐2 Spike Receptor Binding Domain/ACE2 Complex and Main Protease and ADMET Investigations
Authors: Ercan Selami , Pir Meryem 
Published: December 2023

AbstractThe severe acute respiratory syndrome SARS‐CoV‐2 is the causative agent of COVID‐19. Preventing binding of SARS‐CoV‐2 Spike glycoprotein to human ACE2 enzyme and inhibition of MPRO enzyme are still attractive drug targets for treatment of COVID‐19 infection. Boron atom‐containing compounds show anticancer, antibacterial, antiviral, antifungal, antiparasitic, anti‐inflammatory, antituberculosis, anti‐dermatophytic and anti‐fertility activities. In the current study, the ADMET properties of ligands were calculated by the aim of SwissADME and pkCSM pharmacokinetics web tools. The results revealed that the ligands meet drug‐likeness properties. Furthermore, we have performed molecular docking study of boron containing dioxaborepine and oxadiazaborole derivatives to investigate binding properties of ligands against SARS‐CoV‐2 Spike glycoprotein/ACE2 complex and inhibition of MPRO enzyme. Through the ligands a derivative of dioxaborepine showed best binding score against SARS‐CoV‐2 Spike glycoprotein/ACE2 complex with a binding score of −8.93 kcal/mol and a oxadiazaborole derivative exhibited a binding score value of −8.36 kcal which is the best binding ligand to the MPRO enzyme binding site. The analysis of binding poses of ligands and ligand‐residue interactions of the systems revealed that dioxaborepines and oxadiazaboroles could have block binding of Spike glycoprotein to human ACE2 enzyme and could have inhibition effects on MPRO enzyme.
Cyclotides, Cyclic Peptides Derived from Clitoria ternatea Linn Mature Pods, Hold Promise as Potential Antimicrobial Agent
Authors: Tran Tam T. T. , Tran Gia‐Hoa , Cu Son T. , Pham Son H. , Nguyen Tuan H. N. , Dang Tien T. 
Published: December 2023

AbstractCyclotides, cysteine‐rich peptides, are derived from various plant sources. Within the Fabaceae family, Clitoria ternatea Linn distinguishes itself as the only species that has been confirmed to contain cyclotides in its tissues. Several investigations have been undertaken to identify and evaluate the activity of cyclotides derived from the plant. However, the investigation of cyclotides derived from mature pods of C. ternatea remains unexplored. To fill this gap, this study utilized three different extraction methods and employed LC–MS analysis to evaluate their effectiveness in extracting cyclotides. A solution comprising 70 % ethanol and 30 % water exhibited the highest efficacy for cyclotide extraction. A total of 14 cyclotide‐like molecules were successfully identified using this approach. Mixtures of cyclotides M1 and M2 demonstrated significant antibacterial efficacy against Bacillus subtilis (inhibition diameters: 17.83–19.67 mm) and Pseudomonas aeruginosa (inhibition diameters: 19.33–20.33 mm). The minimum inhibitory concentration (MIC) of semi‐purified sample E70‐F2 is 1.56 mg/mL, while the MIC of semi‐purified E70‐F3 is 0.78 mg/mL. The MS tandem technique was utilized to sequence a total of seven known cyclotides. The findings of this study demonstrate considerable potential for the application of cyclotides derived from mature pods of C. ternatea as an environmentally friendly antimicrobial agent.
Recent Update on Alkylation of Indole and Its Derivatives Using N‐Tosylhydrazone
Authors: Vaishya Vartika , Singhal Rakshanda , Mehra Manish K. , Pilania Meenakshi 
Published: December 2023

AbstractN‐Tosylhydrazones are valuable synthons in various organic transformations to achieve potent bioactive heterocycles. N‐tosylhydrazones largely serve as 1,3‐dipolar species for cycloaddition reactions, diazo precursors for carbene or carbenoid reactions, and alternatives to parent carbonyl compounds. On the other hand, indole derivatives exhibit wide range of pharmacological and therapeutic activities including anticancer, antiviral, antimalarial, antiasthmatic, antibacterial and anti‐inflammatory. This review mainly highlights the recent developments in the synthetic usefulness of N‐tosylhydrazones derived from indole‐carboxaldehydes and other carbonyl compounds. Moreover, the synthetic potential, scope, limitations, and mechanism of these transformations have also been discussed.
Hydro‐Photo‐Thermo‐Responsive Multicolor Luminescence Switching of a Ternary MOF Hybrid for Advanced Information Anticounterfeiting
Authors: Cuan Jing , Zhou Hui , Huang Xuefang , Cong Xinhang , Zhou You 
Published: December 2023

AbstractDeveloping smart materials capable of solid‐state multicolor photoluminescence (PL) switching in response to multistimuli is highly desirable for advanced anticounterfeiting. Here, a ternary MOF hybrid showing hydro‐photo‐thermo‐responsive multicolor PL switching in the solid state is presented. This hybrid is constructed by co‐immobilizing Eu3+ and methyl viologen (MV) cations within an anionic MOF via the cation‐exchange approach. The confined guest cations are well arranged in the framework channels, facilitating the synergistic realization of stimuli‐responsive multiple PL color‐switching through intermolecular coupling. The hybrid undergoes a rapid and reversible PL color‐switching from red to blue upon water simulation, which is achieved by activating the blue emission of the framework linker while simultaneously quenching the Eu3+ emission. Furthermore, the hybrid displays photo‐thermo‐responsive PL switching from red to dark. UV‐light irradiation or heating triggers the chromic conversion of MV to its colored radical form, which exhibits perfect spectral overlap with Eu3+, thus activating Förster resonance energy transfer (FRET) from Eu3+ to MV radicals and quenching the Eu3+ emission. Inspired by these results, PL morse patterns are designed and fabricated using a novel triple‐level encryption strategy, showcasing the exciting potential of this hybrid in advanced anticounterfeiting applications.
A 3D Cross‐Linked Metal‐Organic Framework (MOF)‐Derived Polymer Electrolyte for Dendrite‐Free Solid‐State Lithium‐Ion Batteries
Authors: Zhou Jia , Wang Xiao , Fu Jifang , Chen Liya , Wei Xiangrong , Jia Rongrong , Shi Liyi 
Published: December 2023

AbstractLithium metal batteries (LMBs) with high energy density have received widespread attention; however, there are usually issues with lithium dendrite growth and safety. Therefore, there is a demand for solid electrolytes with high mechanical strength, room‐temperature ionic conductivity, and good interface performance. Herein, a 3D cross‐linked metal‐organic framework (MOF)‐derived polymer solid electrolyte exhibits good mechanical and ionic conductive properties simultaneously, in which the MOF with optimized pore size and strong imidazole cation sites can restrict the migration of anions, resulting in a uniform Li+ flux and a high lithium‐ion transference number (0.54). Moreover, the MOF‐derived polymer solid electrolytes with the 3D cross‐linked network can promote the rapid movement of Li+ and inhibit the growth of lithium dendrites. Lithium symmetric batteries assembled with the 3D MOF‐derived polymer solid electrolytes are subjected to lithium plating/stripping and cycled over 2000 h at a current density of 0.1 mA cm−2 and over 800 h at a current density of 0.2 mA cm−2. The Li/P‐PETEA‐MOF/LiFePO4 batteries exhibit excellent long‐cycle stability and cycle reversibility.
Engineering Interfacial Pt─O─Ti Site at Atomic Step Defect for Efficient Hydrogen Evolution Catalysis
Authors: Wang Lei , Mao Zhelin , Mao Xin , Sun Hai , Guo Panjie , Huang Run , Han Chao , Hu Ximiao , Du Aijun , Wang Xin 
Published: December 2023

AbstractThe hydrogen evolution reaction (HER) activity of defect‐stabilized low‐Pt‐loading catalysts is closely related with defect type in support materials, while the knowledge about the effect of higher‐dimensional defects on the property and activity of trapped Pt atomic species is scarce. Herein, small size (5–10 nm) TiO2 nanoparticles with abundant surface step defects (one kind of line defect) are used to direct the uniform anchoring of Pt atomic clusters (Pt‐ACs) via Pt─O─Ti linkage. The as‐made low‐Pt catalysts (Pt‐ACs/S‐TiO2‐NP) exhibit exceptional HER intrinsic activity due to the unique step‐site Pi‐O‐Ti species, in which the mass activity and turnover frequency are as high as 21.46 A mg Pt−1 and 21.69 s−1 at the overpotential of 50 mV, both far beyond those of benchmark Pt/C catalysts and other Pt‐ACs/TiO2 samples with less step sites. Spectroscopic measurements and theoretical calculations reveal that the step‐defect‐located Pt─O─Ti sites can simultaneously induce the charge transfer from TiO2 substrate to the trapped Pt‐ACs and the downshift of d‐band center, which helps the proton reduction to H* intermediates and the following hydrogen desorption process, thus improving the HER. The work provides a deep insight on the interactions between high‐dimensional defect and well‐dispersed atomic metal motifs for superior HER catalysis.
An asymptotically efficient closed‐form estimator for the Dirichlet distribution
Authors: Ho Chang Jae , Kyu Lee Sang , Kim Hyoung‐Moon 
Published: December 2023

AbstractMaximum likelihood estimator (MLE) of the Dirichlet distribution is usually obtained by using the Newton–Raphson algorithm. However, in some cases, the computational costs can be burdensome, for example, in real‐time processes. Therefore, it is beneficial to develop a closed‐form estimator that is as efficient as the MLE for large sample. Here, we suggest asymptotically efficient closed‐form estimator based on the classical large sample theory.
Morin inhibits osteosarcoma migration and invasion by suppressing urokinase plasminogen activator through a signal transducer and an activator of transcription 3
Authors: Yang Jia‐Sin , Chou Chia‐Hsuan , Hsieh Yi‐Hsien , Lu Peace Wun‐Ang , Lin Ya‐Chiu , Yang Shun‐Fa , Lu Ko‐Hsiu 
Published: December 2023

AbstractOsteosarcoma, the most common primary bone cancer that affects adolescents worldwide, has the early metastatic potential to be responsible for high mortality rates. Morin has a multipurpose role in numerous cancers, whereas little is known about its role in osteosarcoma migration and invasion. Therefore, we hypothesized that morin suppresses the invasive activities and the migratory potential of human osteosarcoma cells. Our results showed that morin reduced migration and invasion capabilities in human osteosarcoma U2OS and HOS cells. Moreover, morin inhibited the urokinase plasminogen activator (uPA) expression through a signal transducer and an activator of transcription‐3 (STAT3) phosphorylation. After STAT3 overexpression, the decrease of the migratory potential and uPA expression caused by 100 μM of morin in U2OS cells was countered, indicating that STAT3 contributes to the antimetastatic property of morin in human osteosarcoma cells by reducing uPA. In conclusion, morin may be a potential candidate for the antimetastatic treatment of human osteosarcoma.
The Wild Boar Never Strikes Without Cause: Monstrous Hybrids, National Identity, and Gender in the Horror Movie Chawu
Authors: Höglund Anna 
Published: December 2023

AbstractThe wild boar has found its own unique space in the genre animal horror. The story of the monstrous wild boar describes conflicts between nature and culture, animal and human, and the criticism of civilization is a prominent theme. The place that produced the monstrous boar is important in the genre and it describes monstrous places where something has gone horribly wrong. The landscapes where the wild boar causes destruction are horrid liminal spaces between past and present. This chapter explores themes connected to South Korea’s dark history of colonial oppression and civil wars in the wild boar horror film Chawu (2009). In particular, it addresses issues regarding the construction of national identity, gender, and the hybridization of masculinities in contemporary South Korea.
Shadowing the Brutality and Cruelty of Nature: On History and Human Nature in Princess Mononoke
Authors: van der Linden Martin 
Published: December 2023

AbstractIn the Japanese animated movie Princess Mononoke (1997), humanity’s relationship with nature is commented upon historically by the movie’s director Miyazaki Hayao. Against the backdrop of Japan in the Muromachi period covered with ancient forests and inhabited by marginalized societies in conflict, the movie functions as a speculative fictional tool for Miyazaki to communicate and demonstrate an important historical and historiographic idea to the audience. Going against the romantic and nativist notion that humanity has lost its historical connection and harmony with nature, a major narrative theme in Princess Mononoke is the idea that the relationship between humanity and nature has throughout history always been cruel and brutal, and humans have never been able to fully live in harmony with nature.
Settler Colonial Solutions to Settler Colonial Problems: Settler Cinemas and the Crisis of Colonization of Outer Space
Authors: Lahti Janne 
Published: December 2023

AbstractSettler colonialism tries to master the land, use it, and derive bounty from it, putting tremendous strain on and wrecking environments. This chapter examines settler colonial crises and failures by discussing how the recent blockbuster films Ad Astra and Interstellar tackle imaginary settler projects in outer space in the context of environmental problems and the precariousness of habitability. In both films, the remedy for settler colonial crisis seems to be more settler colonialism. This involves a denial of the fundamental problems settler colonization causes. These films show how settler projects refuse to end, to die out, or to turn back, and how settler colonialism rejects critical self-reflection in the face of human and environmental disasters.
‘I Get to Exist as a Black Person in the World’: Bridgerton as Speculative Romance and Alternate History on Screen
Authors: Posti Piia K. 
Published: December 2023

AbstractIn 2020, a TV drama series adaptation was made of Julia Quinn’s historical romance series Bridgerton (2000–2012). Several choices in the adaptation were inspired by the recent hypothesis that Queen Charlotte was Black, and an unusual number of Black actors were cast in roles that both fictionally and historically have been predominantly reserved for white actors. This article explores the hypothesis’ impact on the adaptation in the intersection of romance, race and history. What notions (historical and contemporary) of romance, race and historical accuracy are challenged and endorsed in contemporary popular media like the Bridgerton series? What are the benefits and setbacks from a decolonial perspective when Black people are cast, and “familiar” history is told, in such “unfamiliar” ways?
Language Mixing in the Contact of Finnish with Swedish, Estonian, and English: The Case of Mixed Compound Nouns
Authors: Kosunen Riitta , Frick Maria , Kolu Jaana 
Published: December 2023

AbstractIn this chapter, we explore the language use of people who speak Finnish as one language and either Swedish, Estonian, or English as another. The analysis concentrates on mixed compound nouns, that is, complex nouns which have one part in Finnish and the other in another language. We discuss how these instances of language mixing reflect the everyday life and discourse practices of the participants and how languages can sometimes be mixed for no detectable reason at all.
‘Somewhere Between Engineering and Humanities’: Discourses of Investment in Additional Language Learning Among Students of Higher Education in Finland
Authors: Räisänen Tiina 
Published: December 2023

AbstractThis chapter investigates discourses of investment in additional language learning among students of higher education in Finland. Additional languages in this context refer to those languages that pupils and students can choose to study. Using the concepts of investment, discourse, and scale, this sociolinguistic and discourse analytical study analyses 18 interviews of higher education students in various fields of technology and examines what kinds of spatial and temporal scales are at play when individuals talk about their investment in additional language learning. The chapter demonstrates how discourses of pleasure/enjoyment, struggle, and profit are drawn on by the students. The study also shows tensions between these discourses that reflect institutional values and neoliberal logic that permeate additional language learning practices and individual motivations in their investment efforts.
Talkin’ ’bout My Integration: Views on Language, Identity, and Integration Among Dutch and Finnish Migrants to the Swedish Countryside
Authors: Bijvoet Ellen , Östman Jan-Ola 
Published: December 2023

AbstractMigration to the sparsely populated countryside in the North of Europe has received relatively little interest. We analyse how Finnish (labour) migrants and Dutch (life-style) migrants who have settled in a rural area in mid-Sweden discuss their challenges in relation to transnational migration. Our focus-group fieldwork data indicate that the Finnish and the Dutch participants have completely different views on what it means to be socially and linguistically integrated into a new home location. Our data also illustrate the intricacies of identity construction in transnational migration situations. We describe the Finns as ‘self-marginalised’ migrants who show little interest in becoming explicitly integrated into the village community, whereas the Dutch settlers as ‘involuntarily marginalised’ migrants are frustrated about the time it takes to become included in the local community. The analyses show the crucial importance of the migrants’ causes for migration and their expectations vis-à-vis social integration into a new community .
Silence and Question Marks in Drawings of Interactional Encounters
Authors: Niemelä Heidi 
Published: December 2023

AbstractIn this chapter, discourses, language ideologies, and visual representations of the Finnish language are analysed in the Finnish primary school context. Pupils from age 11 to 13 from the cities of Oulu and Helsinki were asked to ‘draw the Finnish language’. These visual representations consist of many elements, in which people make a frequent appearance. Most of the people represented in the context of the Finnish language are named as Finns. However, some interactional encounters between native speakers of Finnish and foreigners are also represented, and this chapter focuses on exploring these representations.Six drawings from a data of 102 drawings of the Finnish language are being analysed in this chapter. In these drawings, an interactional encounter of a Finn and a foreigner or a lack of understanding is visualised.This raises a question on the assumed connection between one’s nationality and language. Are foreigners not considered possible speakers of Finnish?