bluuebunny/crossref_metadata_2025_split huggingface dataset:
Transcriptional responses of liver and spleen in Lota lota to polyriboinosinic polyribocytidylic acid
Authors: Lou Fangrui , Zhang Yuan , Xu Anle , Gao Tianxiang 
Published: October 2023

IntroductionThe cultured Lota lota can meet the market demand in the context of the decline of wild resources, but the disease in the high-density culture process also deserves attention. Therefore, understanding the immune regulation mechanisms of L. lota will be the basis for obtaining high benefits in artificial culture.MethodsTo explore the viral response mechanism of L. lota, RNA-seq was applied to identify the transcriptomic changes of the liver and spleen in L. lota by poly (I:C) stress.ResultsThe DEGs (liver: 2186 to 3123; spleen 1542 to 2622) and up-regulated genes (liver: 1231 to 1776; spleen 769 to 1502) in the liver and spleen increased with the prolongation (12h to 48h) of poly (I:C)-stimulation time. This means L. lota needs to mobilize more functional genes in response to longer periods of poly (I:C)-stimulation. Despite the responses of L. lota to poly (I:C) showed tissue-specificity, we hypothesized that both liver and spleen of L. lota can respond to poly (I:C) challenge may be through promoting apoptosis of DNA-damaged cells, increasing the activity of immune-enhancing enzymes, and increasing energy supply based on DEGs annotation information.ConclusionsOur results demonstrate the transcriptional responses of L. lota to poly (I:C)-stimulation, and these data provide the first resource on the genetic regulation mechanisms of L. lota against viruses. Furthermore, the present study can provide basic information for the prevention of viral diseases in L. lota artificial culture process.
The increasing instance of negative emotion reduce the performance of emotion recognition
Authors: Wang Xiaomin , Zhao Shaokai , Pei Yu , Luo Zhiguo , Xie Liang , Yan Ye , Yin Erwei 
Published: October 2023

IntroductionEmotion recognition plays a crucial role in affective computing. Recent studies have demonstrated that the fuzzy boundaries among negative emotions make recognition difficult. However, to the best of our knowledge, no formal study has been conducted thus far to explore the effects of increased negative emotion categories on emotion recognition.MethodsA dataset of three sessions containing consistent non-negative emotions and increased types of negative emotions was designed and built which consisted the electroencephalogram (EEG) and the electrocardiogram (ECG) recording of 45 participants.ResultsThe results revealed that as negative emotion categories increased, the recognition rates decreased by more than 9%. Further analysis depicted that the discriminative features gradually reduced with an increase in the negative emotion types, particularly in the θ, α, and β frequency bands.DiscussionThis study provided new insight into the balance of emotion-inducing stimuli materials.
Determining classes of food items for health requirements and nutrition guidelines using Gaussian mixture models
Authors: Balakrishna Yusentha , Manda Samuel , Mwambi Henry , van Graan Averalda 
Published: October 2023

IntroductionThe identification of classes of nutritionally similar food items is important for creating food exchange lists to meet health requirements and for informing nutrition guidelines and campaigns. Cluster analysis methods can assign food items into classes based on the similarity in their nutrient contents. Finite mixture models use probabilistic classification with the advantage of taking into account the uncertainty of class thresholds.MethodsThis paper uses univariate Gaussian mixture models to determine the probabilistic classification of food items in the South African Food Composition Database (SAFCDB) based on nutrient content.ResultsClassifying food items by animal protein, fatty acid, available carbohydrate, total fibre, sodium, iron, vitamin A, thiamin and riboflavin contents produced data-driven classes with differing means and estimates of variability and could be clearly ranked on a low to high nutrient contents scale. Classifying food items by their sodium content resulted in five classes with the class means ranging from 1.57 to 706.27 mg per 100 g. Four classes were identified based on available carbohydrate content with the highest carbohydrate class having a mean content of 59.15 g per 100 g. Food items clustered into two classes when examining their fatty acid content. Foods with a high iron content had a mean of 1.46 mg per 100 g and was one of three classes identified for iron. Classes containing nutrient-rich food items that exhibited extreme nutrient values were also identified for several vitamins and minerals.DiscussionThe overlap between classes was evident and supports the use of probabilistic classification methods. Food items in each of the identified classes were comparable to allowed food lists developed for therapeutic diets. This data-driven ranking of nutritionally similar classes could be considered for diet planning for medical conditions and individuals with dietary restrictions.
Factors influencing adherence to non-communicable disease medication in India: secondary analysis of cross-sectional data from WHO - SAGE2
Authors: Tolley Abraham , Grewal Kirpal , Weiler Alessa , Papameletiou Anna Maria , Hassan Refaat , Basu Saurav 
Published: October 2023

Background: Non-communicable diseases (NCDs) are a leading cause of death globally and disproportionately affect those in low- and middle-income countries lower-middle-income countries. Poor medication adherence among patients with NCDs is prevalent in India due to lack of initiation, missed dosing or cessation of treatment, and represents a growing healthcare and financial burden.Objective: This study aimed to identify factors influencing medication adherence in adults with NCDs in India.Methods: We performed a cross-sectional study, conducting secondary data analysis on the second wave of the World Health Organisation’s ‘Study on global AGEing and adult health (SAGE)’, a survey that collected data from predominantly older adults across India. Bivariate analysis and multivariate logistic regression modelling were conducted to specifically interrogate the reasons for lack of initiation and cessation of treatment. Reporting of this study was informed by the STROBE guidelines.Results: The average medication adherence rate was 51% across 2,840 patients with one or more NCDs, reflecting non-initiation and lack of persistence of treatment. The strongest factor significantly predicting non-adherence to medication across these components was multimorbidity (odds ratio 0.47, 95% CI 0.40–0.56). Tobacco use (OR = 0.76, CI 0.59–0.98) and never having attended school (OR = 0.75, CI 0.62–0.92) were significantly associated with poor medication adherence (p &lt; 0.05) while rural living (OR = 0.70, CI 0.48–1.02), feelings of anxiety (OR = 0.84, CI 0.66–1.08) and feelings of depression (OR = 0.90, CI 0.70–1.16) were factors lacking statistically significant association with medication adherence on multivariate analysis. Older age (OR = 2.02, CI 1.51–2.71) was significantly associated with improved medication adherence whilst there was a weak association between increased wealth and improved medication use.Limitations: The SAGE2 survey did not capture whether patients were taking their medication doses according to prescribed instructions—as a result our findings may under-estimate the true prevalence of medication non-adherence.Conclusion: Our analysis provides evidence that poor medication adherence in India is multifactorial, with distinct socioeconomic and health-system factors interacting to influence patient decision making. Future large-scale surveys interrogating adherence should assess all components of adherence specifically, whilst public health interventions to improve medication adherence should focus on barriers that may exist due to multimorbidity, comorbid depression and anxiety, and low educational status.
Case report: Remarkable response to sintilimab, lenvatinib, and nab-paclitaxel in postoperative metastatic chemotherapy-resistant combined hepatocellular-cholangiocarcinoma
Authors: Zhou Nan , Lei Chuan-Fen , Tan Si-Rui , Huang Qi-Yue , Zhang Shun-Yu , Liang Zheng-Xin , Gou Hong-Feng 
Published: October 2023

Background: Combined hepatocellular-cholangiocarcinoma (cHCC-CCA) is a highly aggressive malignancy with a poor prognosis. However, there are no consensus treatment guidelines, and decisions are usually extrapolated from intrahepatic cholangiocarcinoma (ICC) or hepatocellular carcinoma (HCC). Given that cHCC-CCA owns the unequivocal presence of both hepatocytic and cholangiocytic differentiation, a combination regimen of anti-PD1 antibody, multikinase inhibitor, and chemotherapy targeting against both components might be an optimal choice.Case presentation: We present the case of a patient with postoperative metastatic chemotherapy-resistant cHCC-CCA who exhibited a durable response and reasonable tolerability to a combination therapy consisting of the anti-PD1 antibody sintilimab, multikinase inhibitor lenvatinib, and nab-paclitaxel, despite having a low tumor mutational burden (TMB-L), microsatellite stability (MSS), and negative programmed cell death 1 ligand 1 (PD-L1).Conclusion: The combination regimen of immune checkpoint inhibitor sintilimab, multikinase inhibitor lenvatinib, and chemotherapy with nab-paclitaxel, which targets both the HCC and ICC components, may represent a promising treatment option for patients with cHCC-CCA. Further research is warranted to validate these findings in larger patient cohorts.
Daily sound exposure of hearing aids users during COVID-19 pandemic in Europe
Authors: Sun Kang , Szatmari Tiberiu-Ioan , Pasta Alessandro , Bramsløw Lars , Wendt Dorothea , Christensen Jeppe H. , Pontoppidan Niels H. 
Published: October 2023

IntroductionThis study aimed to investigate the daily sound exposure of hearing aid (HA) users during the COVID-19 pandemic, with a specific focus on the impact of different governance intervention levels.MethodsModern HA technology was employed to measure and compare the sound exposure of HA users in three distinct periods: pre-pandemic, and two 14-day periods during the pandemic, corresponding to varying levels of governance interventions. The study sample comprised a total of 386 HA users in Europe during the pandemic, with daily sound exposure data collected as part of the main dataset.ResultsThe results revealed that, during the pandemic, the equivalent continuous sound pressure level (SPL) experienced by HA users decreased, while the signal-to-noise ratio (SNR) increased compared to the pre-pandemic period. Notably, this impact was found to be more pronounced (p &lt; 0.05) when individuals were subjected to stronger governance intervention levels, characterized by lower SPL and higher SNR.DiscussionThis study highlights the changes in daily sound exposure experienced by HA users during the COVID-19 pandemic, particularly influenced by the extent of governance interventions that restricted social activities. These findings emphasize the importance of considering the effects of pandemic-related governance measures on the sound environments of HA users and have implications for audiological interventions and support strategies during similar crises.
Functional limitation and happiness among older adults: the multiple mediating role of intergenerational support and intergenerational relationship
Authors: Zhou Angdi , Song Yiwen , Li Xinru , Hu Bingqin , Chen Yitong , Cui Peiyao , Li Jinghua 
Published: October 2023

ObjectivesThis study aimed to investigate the relationship between the functional limitation and happiness among Chinese older people and examined the multiple mediating effects of intergenerational support (instrumental support and financial support) and intergenerational relationship.MethodData was drawn from the Chinese Family Panel Survey (CFPS) 2018 and 2020. Structural equation modeling was adopted to analyze the association among functional limitations, intergenerational support, intergenerational relationship, and the older adults happiness.ResultsThere was a significant association between the functional limitations and the lower happiness levels among the older adults. The instrumental support from adult children positively mediated the relationship between the functional limitation and the happiness. However, intergenerational relationships were reduced due to the dysfunction of the older adults, and played a negatively mediated role between the functional limitation and the happiness. In addition, instrumental and financial support play chain-mediating roles between functional limitation and happiness in older adults through intergenerational relationships.ConclusionIntergenerational relationships and instrumental support enhance the happiness of older adults with functional impairments, but their role is limited by the changing structure of modern families. Long-term care programs combined with the intergenerational support from families for people with functional impairments in old age would be more effective to reduce the burden on adult children and maintain the quality of life of the older adults.
Effect of different disinfectants on preventing asymptomatic bacteriuria and catheter-related urinary tract infection: a network meta-analysis
Authors: Sun Zhi Hong , Ma Xue Wei , Sun Wei , Wei Ying Ji , Li Yi Zhen , Wang Dan , Zhou Chang Xi , Xu Guo Gang , Zhang Gui Zhi 
Published: October 2023

ObjectiveTo analyze the effect of different types of disinfectants for perineum and urethral meatus cleaning in preventing catheter-associated asymptomatic bacteriuria and catheter-associated urinary tract infection (CAUTI).MethodsChinese and English databases were searched to collect randomized controlled trials (RCTs) of different disinfectants for perineum and urethral meatus cleaning to prevent CAUTI, and the positive rates of urine culture with different cleaning methods were contrasted by network meta-analysis.ResultsA total of 18 RCTs were included in this study to analyze the effect of 10 disinfectants in preventing CAUTI. The disinfectants were 0.1% chlorhexidine (CHG), 0.5% CHG, 2% CHG, 0.1% benzalkonium bromide (DBDAB), 0.05% iodophor, 0.5% iodophor, acidic oxidizing potential water (EOW), normal saline (NS), Shehuang lotion, and sterile water. Meta-analysis showed that the positive rates of urine culture in the 0.5% CHG cluster, EOW cluster, 0.5% iodophor cluster, and Shehuang lotion cluster were remarkably lower than that in the 0.1% DBDAB cluster (P &lt; 0.05). The positive rate of urine culture in the 0.5% CHG cluster was remarkably lower than that in the 0.05% iodophor cluster (P &lt; 0.05), whereas the positive rates of urine culture in the 0.5% CHG cluster, 0.5% iodophor cluster, Shehuang lotion cluster, and EOW were remarkably lower than that in the normal saline cluster (P &lt; 0.05). The positive rate of urine culture in the 0.5% CHG cluster and EOW cluster were remarkably lower than those in the sterile water cluster (P &lt; 0.05). The results of the area under the cumulative ranking probability plot (SUCRA) analysis showed that the probability ranking of the preventive effect of different disinfectants was as follows: 0.5% CHG &gt; Shehuang lotion &gt; EOW &gt; 0.5% Iodophor &gt; 2% CHG &gt; 0.1% CHG &gt; 0.05% Iodophor &gt; Sterile Water &gt; 0.1% DBDAB &gt; Saline. Conclusion0.5% CHG, Shehuang lotion, EOW, and 0.5% iodophor can be used to clean the perineum and urethral meatus in patients with indwelling catheters.Systematic review registrationChinese Clinical Trial Registry (ChiCTR), identifier ChiCTR2100052260.
Can cardiac pressure-volume catheters improve urodynamic assessment? an ex-vivo proof-of-concept
Authors: Jahren Silje Ekroll , Obrist Dominik , Haenggi Matthias , Burkhard Fiona , Clavica Francesco 
Published: October 2023

AimsTo explore the feasibility of using pressure-volume (PV) catheters for cystometry. These catheters are well-established in cardiovascular research for simultaneous pressure and volume measurements in the left ventricle.MethodsUrinary bladders with urethras were collected from domestic pigs for ex-vivo testing. Using a pump, bladders were filled up to 500ml at five different filling rates (15, 20, 25, 30, 35ml/min), and the resulting pressures and volumes were measured using a PV catheter. The bladder were compressed externally in three different areas (central, apex and outlet) to assess the PV catheter’s ability to detect local changes in bladder volume.ResultsBladder pressure remained below 10cmH2O for all bladder filling rates. Volume measurements were compared with the volumes instilled by the pump (ground truth), proving high reproducibility and accuracy of the PV catheter measurements up to 400ml. Using the different sensing units of the PV catheter, local changes in bladder volumes could be identified and quantified.ConclusionThe main advantage of PV catheters, compared to existing technology used in urology (e.g. conventional urodynamic testing), is the possibility to i) simultaneously measure bladder pressure and volumes and ii) identify local changes in bladder volume (e.g. caused by non-voiding contractions). Both could be useful in the clinical setting to improve the diagnosis and treatment of the Lower Urinary Tract Dysfunction (e.g. overactive/underactive bladder).
Critical food systems education in university student-run food initiatives: learning opportunities for food systems transformation
Authors: Deskin Zoë Y. , Harvey Blane 
Published: October 2023

IntroductionStudent-run Campus Food Systems Alternatives (CFSA) have been proposed as spaces which have the potential to advance Critical Food Systems Education (CFSE) – the objective of which is to motivate students to act toward radical food systems transformation on community and systemic levels. Evidence on how learning dynamics in CFSA drive student participants to develop critical perspectives on food systems is limited, however. This paper seeks to address this gap by exploring how critical and transformative learning happens in these informal and student-run spaces, by detailing a multi-case study of students’ learning experiences in four student-run CFSA on the McGill University campus.MethodsData on students’ learning experiences was collected through observational field notes of CFSA activities and semi-structured Interviews with student facilitators. Thematic and cross-case analysis was performed with interview data.ResultsAnalysis of students’ described learning experiences in CFSA revealed three broad categories of learning dynamics which drive students’ learning about food systems and their willingness to act for food systems change: hands-on work in informal spaces, social connection and engagement between student participants, and engagement with the beyond-campus community.DiscussionEngagement with the beyond-campus community via CFSA, particularly that which involved exposure to food-related injustice in marginalized communities, was found to be particularly important in driving student participants’ critical reflection on food systems and willingness to act toward food justice. A lack of intentional critical reflective practice was however observed in CFSA, calling into question how this practice can be driven in campus food initiatives without compromising their student-run and informal structures.
The outcomes of proximal femur replacement with hemiarthroplasty after tumor resection in individuals with Parkinson's disease
Authors: Zhao Zhiqing , Wang Jichuan , Guo Yu , Niu Jianfang , Guo Wei , Yang Rongli , Yan Taiqiang , Tang Xiaodong 
Published: October 2023

BackgroundPatients with neurological disorders often experience a high incidence of postoperative complications following proximal femur replacement (PFR) surgery. The orthopaedist faces a significant difficulty in treating Parkinson's disease (PD) because of the weakened bone condition, excessive muscle tension, and increased risk of fractures. The objective of this research is to assess the impact of PD on PFR following tumor removal.MethodsA retrospective study was conducted from 2010 to 2020, focusing on a solitary institution, analyzing 9 patients diagnosed with PD who underwent PFR with hemiarthroplasty as a result of tumor removal. The study consists of 2 men and 7 women, with an average age of 71 (SD, 12) years. We assessed the outcomes after surgery in terms of pain management, quality of life, functional ability, occurrence of complications, and survival durations.ResultsAll nine patients underwent planned surgeries. Intraoperative complications was not observed. The average length of the follow-up period was 24 (SD, 20) months, ranging from 8 to 72 months. Despite the fact that 8 patients passed away due to tumor progression, the endoprostheses were still well at that point. The preoperative VAS score of 7 (SD, 1.87) decreased to a postoperative score of 2 (SD, 1.32). The KPS was improved to73 (SD, 7) from 52 (SD, 14), postoperatively. Post-surgery, there were notable enhancements in both pain levels and the overall quality of life scores. Following the surgical procedure, individuals are able to ambulate steadily, resuming their regular daily routines. Living patients had an average MSTS score of 21 (SD, 2.5), ranging from 17 to 25. In total, there were four (44.4%) patients suffered complications after surgery, comprising of one wound dehiscence, one prosthetic fracture, one hip dislocation, and one local recurrence.ConclusionsSignificant improvements in function and pain relief can be achieved through PFR with hemiarthroplasty following tumor removal in patients with PD. The implementation of thorough preparation and carefull nursing results in reduced complications and improved outcomes in PD patients.
Methodological comparison of cancellation versus two-way choice spatial attention tests in humans and dogs
Authors: Kis Anna , Radics Eszter , Bolló Henrietta , Topál József 
Published: October 2023

IntroductionBehavioural problems in family dogs are amongst the leading reasons for relinquishment to shelters which adversely affects animal welfare. Recent research suggests that certain problematic behavioural patterns might be analogous to human psychiatric disorders. Veterinary diagnosis of such conditions, however, is scarce, probably due to the lack of appropriate measurement tools. The current study focuses on dog behaviour resembling the human hemispatial neglect condition, which manifests itself as a deficit in attention to and awareness of one side of the space.MethodsHealthy human subjects (N = 21) and adult family dogs (N = 23) were tested with tools aimed to measure spatial attention. Tests administered to humans included validated paper and pencil neuropsychological tools to assess hemispatial neglect (cancellation tasks), as well as the canine version of that task (visuo-spatial search task). Dogs were tested with the same visuo-spatial search task as well as a two-way choice task.ResultsResults show that both in case of dogs and humans the visuo-spatial search task detects individual variation in subjects’ side preferences. However, subjects’ performance in the different tasks were not related.