bluuebunny/crossref_metadata_2025_split huggingface dataset:
The Neuroeducation Approach to Language Learning: Exploring Learner Perception
Authors: Yusuf Nermin Hosny 
Published: January 2025

Abstract

This study investigates learner perceptions of the LIRRA Neuroeducation Program (LIRRA-NP), a neuroeducation program designed to enhance second language (L2) acquisition and reading proficiency in intermediate undergraduate learners. Building upon previous research demonstrating the program's effectiveness (Yusuf, 2024), this study explores learner experiences with the program's implementation, content, design, and perceived impact on their language skills. Thirty intermediate-level English learners participated, completing an online questionnaire comprising scaled and open-ended questions where quantitative data were analyzed using descriptive statistics, and qualitative data were analyzed thematically. Results revealed overwhelmingly positive perceptions of the LIRRA-NP, with participants finding it interesting, motivating, relevant, and beneficial. They particularly appreciated the program's content, novelty, and engaging activities. This study contributes to the optimization of L2 acquisition through neuroeducation by providing valuable learner feedback to inform the development of future programs and enhance student-centered learning methods.
geoSABINA: a unified plant ecology database for Spain
Authors: Goicolea Teresa , Morales-Barbero Jennifer , García-Viñas Juan Ignacio , Gastón Aitor , Aroca-Fernández María José , Calleja Juan Antonio , Moreno Juan Carlos , Ramos-Gutiérrez Ignacio , Rodríguez Miguel Á. , Lima Herlander , Broennimann Olivier , Guisan Antoine , Adde Antoine , Pérez-Latorre Andrés V. , Mateo Rubén G. 
Published: January 2025

Abstract

Spatial ecological databases are crucial for understanding and managing biodiversity and ecosystem services. The geoSABINA database provides spatially explicit datasets to support plant ecological research and conservation throughout mainland Spain. It integrates high-resolution spatial data of four main categories: (I) plant occurrence data, (II) environmental variables, (III) species distribution models, and (IV) thematic maps for conservation and management. The plant occurrence dataset includes georeferenced records for 81 tree and 101 shrub native species, and atlas data for 6,456 vascular plants and 1,252 bryophytes. Environmental variables encompass climatic, edaphic, hydrological, and solar, factors influencing plant distribution. Species distribution models employ a hierarchical approach for trees and a traditional approach for shrubs. Thematic maps include species richness for woody and protected plants, distribution of vegetation types, and forest connectivity. All climatic variables, models, and thematic maps are projected under current and four future climate scenarios (2070–2100). geoSABINA is openly available on Zenodo and supports an online geoportal for data visualization and download. geoSABINA standardizes ecological data, advancing research and informed conservation and policy.
Chemoreactome analysis of methylethylpyridinol and possible mechanisms of ophthalmoprotection
Authors: Gromova O. A. , Torshin I. Yu. , Gromov A. N. 
Published: January 2025

Introduction. Methylethylpyridinol (MEPD or Emoxypine) is widely used in practice to treat various eye diseases, exhibiting angioprotective, antiplatelet, antioxidant effects. The molecular mechanisms for the implementation of these and other pharmacological effects of MEPD are not entirely obvious.Aim. To conduct a chemoreactome analysis of MEPD aimed at identifying the molecular mechanisms of the drug action. Materials and methods. The pharmacological/biological properties of MEPD were assessed using methods for chemoinformatic analysis of molecules developed in the scientific school of RAS academicians Yu.I. Zhuravlev and K.V. The analysis procedure is based on the latest machine learning technologies developed in the theory of topological and metric analysis of feature descriptions in application to chemographs.Results and discussion. The results of chemoproteomic profiling of MEPD showed anti-inflammatory, antihypoxic, antioxidant, vasoprotective and vasorelaxant effects of the drug. By inhibiting arachidonate-5-lipoxygenase, leukotriene A4 hydrolase, leu kotriene LTB4 and prostanoid receptors, inhibiting the production of superoxide anions and leukotriene, MEPD helps to reduce local inflammation in eye tissues. Evaluations of the vasodynamic and neuroprotective effects of MEPD in vitro, obtained as a result of chemoreactome analysis, indicated neurotrophic, neuroprotective and vasodilatory effects of MEPD. The neurotrophic effect in vitro in cultured sensory neurons and neuroprotective activity, assessed by the protective effect against L-homocysteine, exceeded the activity of control molecules. The analysis demonstrated the vasodilatory activity of MEPD and the reduction of intraocular pressure in vivo.Conclusions. Based on the results of the chemoreactome analysis, new molecular mechanisms of the anti-inflammatory action of MEPD in eye tissues were proposed, carried out through the inhibition of certain target proteins. The antioxidant properties of MEPD can be associated with both specific interactions with proteome proteins (e.g., activation of antioxidant proteins) and with the direct action of the molecule on reactive oxygen species.
Realities and prospects of hormonal therapy for recurrent urinary tract infections in patients with genitourinary menopausal syndrome
Authors: Yarmolinskaya M. I. , Cherkashina S. A. 
Published: January 2025

The problem of the growing elderly population, called the “silver tsunami”, is becoming increasingly important for modern society, including healthcare. Increasing women’s life expectancy makes it a national priority to consider improving women’s quality of life and active healthy longevity. GSM (Genitourinary Menopausal Syndrome), which is primarily a consequence of estrogen deficiency in periand postmenopausal patients and is characterized by changes in the genitourinary organs, is underdiagnosed.The most common complaints are vaginal dryness, irritation, and dyspareunia. One of the components of GSM is urinary tract infections (UTIs), which tend to recur. Approximately 53% of women aged about 55 years report a relapse within one year. Recurrent UTIs negatively affect the quality of life of patients and are the reason for prescribing repeated courses of antibacterial therapy, which is accompanied by a change in the drug resistance of microorganisms. The pathogenesis of UTIs is associated with ascending infection by uropathogenic microorganisms, most often Escherichia coli, against the background of estrogendeficient changes in the epithelium and impaired microbiocenosis of the urogenital zone. Inadequacy of the urothelium and the lack of lactobacilli capable of direct and indirect inhibition of the growth of pathogenic microorganisms lead to colonization of the urinary tract with uropathogens and recurrence of UTIs. Consequently, the use of a vaginal combination of estriol and lactobacilli in the form of long-term intermittent maintenance treatment in order to maintain effectiveness and prevent relapses becomes pathogenetically justified. This combination contains a minimal effective dose of estriol (0.03 mg) with negligible systemic absorption and has a low level of adverse events, which ensures safety and high patient adherence to therapy. However, further clinical studies of the combination of estriol with lactobacilli in postmenopausal patients with recurrent urinary tract infections are needed to improve the efficacy of therapy.
The Demise of Modernist Buildings in Khor Dubai: A Case Study on the FNCB Building
Authors: Saffarini Rasha 
Published: January 2025

Khor Dubai, or Dubai Creek, is the historic district that went through the first layer of development before the urban expansion to the desert. It witnessed profound architectural transformations in three economic phases: the pearl trade, oil discovery, and real estate. Today, early modernist buildings have been replaced with high-rise buildings to meet the financial demands of real estate. This replacement has been a rapid process, making it difficult for the Modern Heritage Initiative of Dubai (MHID) to cease it. In the creek, the First National City Bank building (FNCB) is one of the buildings that marked modernity yet failed the test of time. This study aims to illustrate the economy’s impact on Dubai’s modern heritage, focusing on the FNCB. It also identifies the issues that hinder preserving the architectural heritage of smaller buildings. A descriptive research methodology is employed for this study using visual analysis, site visits, and conversations to illustrate the rise and fall of modernist structures. The findings establish that due to Dubai’s fast-paced growth, replacing heritage is more profitable to sustain the ever-growing demands of Dubai as a real estate hub. It also discusses the importance of immaterial and material values historic buildings hold despite how insignificant they seem now.
Risk assessment of urban water network triggered by social behavior due to rising water demand within households
Authors: Sadeghfam Sina , Amjadi Shahin , Abadi Bijan , Moazamnia Marjan 
Published: January 2025

ABSTRACT

This study assesses the risk of the urban water network (UWN) using social and spatially driven GIS datasets to provide proof for the areas of the UWN that receive the greatest impacts from the residents' behavioral patterns. Little is known about how urban residents’ cognitive systems trigger the risk of not meeting demand (NMD). The study formulates the risk of NMD as the product of hazard and vulnerability using the fuzzy catastrophe scheme. As a triggering event, the hazard refers to the residents' behavioral patterns during the COVID-19 pandemic, and vulnerability points to the technical characteristics of UWN. For visualizing the hazard for NMD within the household-UWN complex, the study benefited from a cross-sectional survey of 356 citizens in the Maragheh township. The low-to-high risk indices were classified into Bands 1–5, respectively. The central part and some parts in the southwest and southeast are located in Band 5, overlapping traditional parts of the city. The path analysis, utilizing socially based and spatially driven GIS datasets within the household-UWN complex, identifies a significant impact of attitude toward COVID-19 and risk. Generally, parts of UWN with the highest risk are located where citizens have the least average attitude toward water-saving behavior.
Synthesis and evaluation of chitosan/essential oil nanoemulsion beads for water treatment
Authors: Ghafri Mallak S. AL , Shuaili Marwa A. AL , Ghafri Jumana M. AL , Alkhatib Mayson H. , AL-yahyai Hanan S. , Al-Broumi Mohammed A. , Azri Mohammed AL , Alyaqoobi Sausan S. , AlSaidi Wafa S. 
Published: January 2025

ABSTRACT

Water treatment receives wide attention due to its close relationship with the environment and its protection from pollutants. This study investigates the effectiveness of applying chitosan/essential oil/nanoemulsion (NE) hydrogel beads in water treatment, which were produced by combining chitosan and various NEs containing different fractions of mixed surfactants of tween 80 and span 20, oils of either clove or peppermint, and distilled water. The physicochemical properties were determined using the scanning electron microscope (SEM), differential scanning calorimetry (DSC), and Fourier transform infrared (FTIR). SEM images exhibited that the clove beads presented sharp edges with parallel lines of networks and uniform pores (6.947 ± 1.45 μm, coefficient of variation (CV) = 20%), whereas peppermint beads displayed a spongy surface with spherical pores (11.203 ± 3.34 μm, CV = 29%). DSC analysis revealed that both clove and peppermint beads were thermally stable until 100 °C. The FTIR curve of the beads displayed new peaks confirming chemical interactions between the chitosan and the constituents of the NE. The adsorption capacity of the beads for the copper sulfate and bromophenol blue was more than 50% achieved within 1 h at 25 °C. In conclusion, chitosan–NE hydrogel beads have promising potential for use in water treatment.
Dialog kulturowy czy promowanie idei? - sytuacja chrześcijaństwa w Republice Chińskiej w świetle wybranym międzywojennym czasopiśmiennictwie w latach 1931-1939
Authors: Michalewicz Katarzyna 
Published: January 2025

Polscy międzywojenni dziennikarze wiele miejsca poświęcali w swoich tekstach zagadnieniu rozwoju chrześcijaństwa w jego różnych odłamach (katolickim, protestanckim i prawosławnym). Zazwyczaj skupiali się przy tym na przedstawianiu działalności organizacji chrześcijańskich, ukazywali wpływ elit na szerzenie się religii chrześcijańskich, a także opisywali działalność misyjną Kościołów. W niniejszym artykule przeanalizowano wybrane artykuły z polskiego międzywojennego czasopiśmiennictwie (lata 1931-1939) jako przykład medialnie zapośredniczonej komunikacji międzykulturowej. Przedmiotem badań w szczególności stała się tematyka artykułów dotyczących działalności misjonarzy w Chinach, jak też sposób, w jaki dziennikarze opisywali owe misje. Dziennikarze bardziej podkreślali w swoich relacjach dobroczynną działalność misji, niż działania mające na celu szerzenie chrześcijańskiej moralności i zachodnich wzorców kulturowych (odmiennych od tych reprezentowanych przez tradycyjne wierzenia chińskie, jak buddyzm, taoizm i konfucjanizm). W szczególności zbadano wydźwięk prasowych wypowiedzi oraz zgodność relacji medialnych z faktami historycznymi. W artykule dowiedziono przykładowo, że dziennikarze słusznie podkreślali duchową, społeczną (w tym szczególnie oświatową i medyczną) rolę misjonarzy i innych duchownych, ale (mimo tego, zazwyczaj dobrze orientowali się w tej tematyce) czasami zdarzało im się popełniać błędy faktograficzne, czy upowszechniać uproszczone wizje rzeczywistości, niepoparte wiedzą naukową. Mowa tu w szczególności o operowaniu sloganami, a także o szerzeniu stereotypów (na przykład nieuargumentowanych sądów o wyższym poziomie chińskiej moralności względem moralności Zachodu). Badanie pokazało, że wydźwięk artykułów na temat roli misji w rozwoju chrześcijaństwa w Chinach miał przede wszystkim charakter propagandowy. Przeanalizowane narracje prasowe z tego okresu nie tylko dostarczają wiedzy z zakresu medioznawstwa, ale również ukazują kulturowe uwikłania komunikacji medialnej i problemy, jakie się z tym wiążą.
Clinicopathological and in Silico Insights into Male Infertility: Agerelated Trends and Anti-sperm Antibodies Post COVID-19 Vaccination
Authors: Alkireidmi Mohammed Ahmed , Mehanna Mohamed Gamil , Baig Mirza Rafi , Alabbasi Fahad A. , Almalki Naif Abdullah R. , Asar Turky Omar , Firoz Ahmad , Kumar Vikas , Anwar Firoz 
Published: January 2025

Background:
Infertility was often considered a female issue, but male infertility
emerged significantly after the Covid-19 pandemic. Hence, assessments are crucial
for planning policies on health care and family planning and reasons thereof post vaccinations.

Material and Methods:
The present study was a case-control, dual-centers, prospective
study with normal sperm parameters. Semen samples collected by masturbation for
idiopathic reasons were conducted at King Abdulaziz University with 133 samples, followed
by molecular modeling via interaction between IZUMO1, Alpha2A adrenergic receptor,
and Fibroblast growth factor receptor 2 protein with IgA antibody produced post
vaccination/infection.

Results & Discussion:
The infertile males under 30 (21%), 31-40 (50%), 41-50 (24%)
and over 50 (5%), with altered sperm motility grades are A (8.45%), B (11.1%), C
(15.8%), and D (59.8%) were reported. Liquefaction times range from 36 to 30 minutes
by age, with abnormal sperm percentages between 43.85% and 46.33%. Protein molecular
interaction between IZUMO1, Alpha2A adrenergic receptor, and Fibroblast growth
factor receptor 2 protein with IgA antibody shows cumulative length of 25.354 Å,
39.049 Å, and 41.999 Å, respectively, with significant interaction between atoms chain,
amino acid, marked variation in bond length.

Conclusion:
Male infertility peaks at 31-40 years, with lowering in men aged 41-50
years, IgA antibody reduced sperm motility, causing immunogenic infertility exacerbated
post-Covid-19 vaccination or infection. Interaction of IgA and various receptors produced
stable interactive molecules of IgA and proteins on sperm, affecting motility, aliquefication,
and abnormal sperm percentage disturbing the normal dynamics of sperm
cells opening a new dimension of infertility among males.
Fe3O4@TiO2 Magnetic Nanocomposite Catalyzed Sustainable Synthesis of Dihydro[1]benzopyrano[h][1]benzopyrans and Antimicrobial Activity
Evaluation
Authors: Abdolmohammadi Shahrzad , Janitabar Darzi Simin 
Published: January 2025

Abstract:
The present study's exploration of innovative techniques for the production of heterocyclic
scaffolds was prompted by the significance of [1]benzopyran motifs in bioactive chemicals. Given
the appealing aspects of creating innovative methodological techniques while working with heterogeneous
nanocatalysts, we desired to use this method to synthesize a number of dihydro[
1]benzopyrano[h][1]benzopyrans. This work set out to demonstrate the prepared Fe3O4@TiO2
nanocomposite's catalytic efficacy as a magnetically separable catalyst in the production of dihydro[
1]benzopyrano[h][1]benzopyrans. 3,9-diamino-1,7-diaryl-1,7-dihydro[1]benzopyrano[8,7-
h][1]benzopyran-2,8-dicarbonitriles were obtained in an easy-to-manage manner by utilizing a
Fe3O4@TiO2 nanocomposite as an effective catalyst in an aqueous medium at 70°C. The in vitro
antimicrobial activities of some synthesized compounds were tested by the disk diffusion method. A
number of target molecules, dihydro[1]benzopyrano[h][1]benzopyrans, were successfully synthesized
in high yields. The results of the antimicrobial experiment showed encouraging antibacterial
effects. This study offered significant advantages of high yield and practical methodology for the
synthesis of dihydro[1]benzopyrano[h][1]benzopyrans. The utilization of aqueous ethanol as an environmentally
friendly medium and the Fe3O4@TiO2 nanocomposite as a magnetically separable catalyst
are examples of how this work adhered to the principles of green chemistry. The biological effectiveness
of some of the produced compounds was tested against both Gram-negative and Grampositive
bacteria.
Antibodies against Alzheimer's: Pioneering a New Era in Treatment Strategies
Authors: Verma Mansi , Singh Niraj Kumar , MS Mohd Usman 
Published: January 2025

Abstract:
Alzheimer's disease, characterized by cognitive decline, memory impairment, and the
presence of abnormal proteins or aberrant proteins like tau tangles and beta-amyloid plaques in
the brain, despite intensive scientific efforts, has no known treatment, posing a significant global
healthcare challenge. Antibody-based therapies have received more attention recently as possible
Alzheimer's disease treatments. An extensive review of the state of research on antibody-based
compounds as potential Alzheimer's disease treatments is given in this study. In addition to examining
the difficulties and constraints encountered during development, it briefly overviews their
mechanisms of action, therapeutic efficacy, and safety profiles. The study also emphasizes important
factors to consider when developing antibody-based treatments, including safety concerns,
dosage schedules, and patient selection standards. To sum up, antibody-based treatments
have a bright future for treating Alzheimer's. Despite current obstacles, mounting data indicates
that these treatments have a great deal of promise to either slow or stop the progression of this
debilitating condition, which could improve the quality of life for the millions of people and families
who suffer from Alzheimer's disease globally.
Evaluation of Safety and Efficacy of Repeated Mesenchymal Stem Cell
Transplantation in Patients with Amyotrophic Lateral Sclerosis (ALS) by
Investigating Patient’s Specific microRNAs as Novel Biomarkers: A Clinical Trial Study
Authors: Alkhazaali-Ali Zahraa , Sahab-Negah Sajad , Boroumand Amir Reza , Farkhad Najmeh Kaffash , Khodadoust Mohammad Ali , Ganjali Rashin , Tavakol-Afshari Jalil 
Published: January 2025

Background:
Since there is currently no cure for amyotrophic lateral sclerosis (ALS),
it is essential to search for diagnostic biomarkers and novel treatments to reduce the severity of
this disease. One of these treatment approaches is stem cell transplantation

Objective:
This study aims to evaluate the safety and efficacy of repeated transplantation of autologous bone marrow-derived mesenchymal stem cells (BM-MSCs) in patients with ALS by analyzing clinical and molecular data.

Methods:
This one-arm, single-center, open-label without a control group, prospective clinical
trial, twenty-one confirmed ALS patients entered the study based on defined inclusion and exclusion criteria and underwent repeated stem cell transplantation (3 times BM-MSCs transplantation
(1×10^6, MSC/Kg BW per injection) concurrently intrathecally (IT) and intravenously (IV), with
one-month interval). Clinical assessment using ALS functional rating scale-revised (ALSFRS)
and forced vital capacity (FVC) values and also molecular investigation by evaluating specific microRNAs expression (mir206, 133a-3p, 338-3p) in patient's serum and Cerebra spinal fluid (CSF)
samples were done three times during the 3-month follow-up period.

Result:
No serious adverse effects were reported during the study. Besides, significant improvement in FVC when compared the baseline with the end of the research and the p-value was
(0.036), and stability in ALSFRS was observed, and the p-value was (p=0.16) following stem cell
transplantation in patients; also, the mentioned microRNA expression was non-significant (p >
0.05) as reported as well.

Conclusion:
Our results demonstrated that repeated transplantation of BM-MSCs was a safe procedure in ALS patients, leading to delay in disease progression and improvement in clinical symptoms. Future studies are needed to confirm these results.
Revealing miRNAs' Janus-Faced Nature: Transforming Cold Tumours into Immunotherapy Hotspots and Overcoming Chemoresistance
Authors: Sen Shinjini , Nayak Ranu , Bondhopadhyay Banashree , Bose Sudeep 
Published: January 2025

Abstract:
In cancer research, tumour complexity and treatment resistance have become more
prevalent. Especially microRNA (miRNA) modulation has recently come into light as a promising
strategy in cancer immunotherapy, particularly in converting "cold" tumours with limited
immune cell infiltration into "hot" tumours responsive to immunotherapy. Tumour microenvironments
are influenced by miRNAs, while specific miRNAs are targeted in cold tumours to
enhance the immune response, potentially improving therapeutic efficacy. A miRNA profiling
approach may enable earlier cancer detection and personalized treatments, emphasizing its importance
for oncology in the future. This review sheds light on miRNA's role in cold and hot
tumour microenvironments, that how they can modulate depending on the tumour niche. Furthermore,
therapeutic resistance might develop over time and aid to decrease the efficacy of miRNA
regulation. To address the hurdles of finding relevant miRNAs to target, researchers may use
high-throughput sequencing methods to characterise miRNA expression across tumour subtypes.
They may also use bioinformatics tools and databases to analyse massive amounts of miRNArelated
data and find prospective candidate miRNAs.