bluuebunny/crossref_metadata_2025_split huggingface dataset:
Impact of pecking amplitude on cyclic fatigue of new nickel–titanium files
Authors: Pedullà Eugenio , Carlesi Teocrito , Pappalardo Alfio , Canova Francesco Saverio , Malagnino Vito Antonio , La Rosa Giusy Rita Maria , Generali Luigi 
Published: December 2023

AbstractObjectivesThe aim of this study is to determine the cyclic fatigue resistance of Mtwo Minimal in static and dynamic tests, with different amplitudes of pecking movements, at intracanal temperature.Materials and MethodsTwo hundred new 25‐mm Mtwo Minimal rotary files (#10/0.035, #17.5/0.045, #25/0.05, #40/0.03, #45/0.03) were tested in static and dynamic cyclic fatigue tests at 35°C (±1°C). An artificial stainless‐steel canal was used. In the dynamic mode, axial movements were set at 1 and 3 mm. The number of cycles to fracture (NCF) was recorded and statistically analyzed by one‐way analysis of variance (p < 0.05).ResultsThe 3‐mm dynamic test showed significantly increased NCF than the other tests for the #10/0.035, #17.5/0.045, and #25/0.05 files (p < 0.05). The #40/0.03 and #45/0.03 files showed no significant differences in all the tests (p > 0.05).ConclusionMtwo Minimal showed higher cyclic fatigue resistance in the dynamic test than the static test, except for the larger instruments. The 3‐mm pecking amplitude increased the cyclic fatigue resistance of the smaller instruments.
Single Step Upgradation of Isatin to Bioactive Fused Heterocycles via Ring Expansion Reactions
Authors: Chandramani Raksha , Nair Ajil R. , Sreekumar Anjana , Aerathupalathu Janardhanan Jayakrishnan , Sivan Akhil 
Published: December 2023

AbstractIsatin, also known as indoline‐2,3‐dione, is a fused, N‐heterocyclic aromatic compound first isolated and purified in 1841. Since then, isatin and its derivatives emerged as a hot research topic for the scientific community. The number of research publications on isatin justifies their popularity. Researchers explored isatins and their derivatives as potential candidates in multidisciplinary research areas, including medicinal chemistry, synthetic organic chemistry, and polymer science. Synthetic chemists’ perspective of tailoring isatin and its family members led to more efficient synthesis strategies in which ring‐opening reactions of isatins were particularly significant due to the product's importance. Our investigation aims to group the different types of cascade ring expansion reactions of isatin to synthesise fused heterocyclic compounds such as derivatives of quinolines, quinazolinones, acridines, acridones, and few spiro heterocyclic compounds, all of which highlight an inevitable role in the field of medicinal chemistry.
STGNet: Short‐term residential load forecasting with spatial–temporal gated fusion network
Authors: Feng Ding , Li Dengao , Zhou Yu , Zhao Jumin , Zhang Kenan 
Published: December 2023

AbstractWith the continuous transformation of the global power system, ensuring the flexibility and stability of the power system has become a direction that the global energy industry has been striving for. This puts forward higher requirements for load forecasting, especially high‐precision short‐term residential load forecasting. However, the high volatility and uncertainty of electric consumption make this problem challenging. Existing methods usually focus on capturing temporal correlations and ignore the underlying spatial correlations in historical loads, which is crucial for accurate forecasting. In this paper, we propose a novel spatial–temporal gated fusion network (STGNet) for short‐term residential load forecasting including not only individual residential load but also aggregated load. By seeking both adaptive neighbors and temporal similarity neighbors, we construct a dynamic graph based on a data‐driven method. On this basis, we provide an adaptive graph gated fusion mechanism to capture fine‐grained node‐specific spatial dependence more accurately and comprehensively. Finally, a bidirectional gated recurrent unit (BiGRU) is utilized to learn the temporal dependence of load data. Extensive experiments on real‐world datasets are conducted and demonstrate the superiority of STGNet over the existing approaches.
Clinical validation of serum immunosignatures in early diagnosis of Crohn's disease
Authors: Ma Xianzong , Zhang Wenyu , Wang Xin , Yang Lang , Jiao Juan , Jia Yan , Wang Dezhi , Xu Junfeng , Jin Peng , Zhang Mingjie , Li Shirong , Pan Yuanming , Sheng Jianqiu 
Published: December 2023

AbstractBackgroundThe search for biomarkers suitable for early diagnosis of Crohn's disease (CD) is challenging. This study investigated the efficacy of serological markers for the early diagnosis of CD.MethodsThis was a retrospective nested cohort study. Indirect immunofluorescence and enzyme‐linked immunosorbent assay were used to detect ASCA IgG, ASCA IgA, AYMA IgG, AYCA IgG, FI2Y IgG, p‐ANCA IgG, GAB IgG and PAB IgG in patient serum samples.ResultsThe positive rates of ASCA IgG, ASCA IgA, AYMA IgG, AYCA IgG, FI2Y IgG, p‐ANCA IgG, GAB IgG and PAB IgG in patients with early CD, advanced CD and other intestinal diseases were 37.0% versus 56.8% versus 27.8%; 3.7% versus 20.5% versus 19.4%; 14.8% versus 2.3% versus 2.8%; 25.9% versus 9.1% versus 8.3%; 18.5% versus 15.9% versus 8.3%; 0.0% versus 2.8%, 18.5%; 13.6% versus 18.2% versus 16.7%; and 7.4% versus 20.5% versus 0.0%, respectively. The positive rates of ASCA IgG, AYCA IgG and PAB IgG were significantly different among the three groups (p < 0.05). In 85.2% of early CD patients, at least one antibody was detected 1 year before diagnosis. The sensitivity of the ASCA/AYMA/AYCA/FI2Y/GAB combination for early diagnosis was 85.2%. The sensitivity of the ASCA/AYMA/AYCA/FI2Y/GAB/PAB/PANCA combination for differentiating CD from other diseases was 87.3%.ConclusionsASCA IgG and AYCA IgG have potential value in identifying the course of CD. AYCA IgG may be a potential marker for the early diagnosis of CD, and ASCA IgG indicates an advanced stage. The combination of ASCA, AYMA, AYCA, FI2Y, and GAB improves early diagnostic accuracy of CD.
Cryptoassets: Definitions and accounting treatment under the current International Financial Reporting Standards framework
Authors: Parrondo Luz 
Published: December 2023

AbstractThis paper provides a first comprehensive definition of cryptoassets for accounting purposes in the types of payment tokens, electronic money (e‐money) tokens, utility tokens and security tokens. The delivery of definitions for accounting purposes addresses some of the concerns raised by the European Financial Reporting Advisory Group (EFRAG) discussion paper and helps accounting regulators adapt current International Financial Reporting Standards (IFRS) standards to blockchain‐based tokens' taxonomy and nature. The paper helps policymakers reconcile Markets in Cryptoassets Regulation Proposal's (MiCA) definitions and classification of cryptoassets with the EFRAG's specific needs for clarification and/or amendment in the IFRS standards and contributes to providing an accounting guide for practitioners in their financial disclosure.
MicroRNA and granulocyte‐monocyte adsorption apheresis combotherapy after inadequate response to anti‐TNF agents in ulcerative colitis
Authors: Sáez‐González Esteban , Moret‐Tatay Inés , Bastida Guillermo , Aguas Mariam , Iborra Marisa , Nos Pilar , Beltrán Belén 
Published: December 2023

AbstractBackgroundUlcerative colitis (UC) is an inflammatory bowel disease characterized by chronic inflammation of the gastrointestinal tract, affecting millions of individuals throughout the world, and producing an impaired health‐related quality of life. Granulocyte and monocyte apheresis (GMA) is a therapeutic option for UC management to induce remission by selective removal of activated leukocytes from bloodstream. Despite the knowledge of the important role of epigenetics in UC pathogenesis, and in the response to different treatments, nothing is known about the role of microRNAs in GMA therapy in UC patients.MethodsSeven consecutively UC patients who started GMA in combo therapy with infliximab were recruited. Peripheral blood samples were taken before the apheresis session, at the start of the induction (S0) and at the end (S10). They were follow‐up during the induction phase (10 sessions: 2 sessions for a week during 3 wk and 1 session for a week during 4 wk) of the treatment at a tertiary hospital (Hospital la Fe) and 6 mo after finishing the GMA induction therapy. MiRNA was extracted and analyzed by RT‐PCR. R software and GraphPad were used.ResultsClinical disease activity significantly decreased after induction therapy with GMA (median partial Mayo score 2 (IQR, 1‐6) (P < .05). Fecal calprotectin value and CRP value significantly decreased after induction therapy. Five microRNAs modified their expression during GMA (unsupervised analysis): miR‐342‐3p, miR‐215‐5p, miR‐376c‐3p, miR‐139‐5p, and miR‐150‐5p. When a sub‐analysis was performed in those patients who showed good response to apheresis treatment (n = 5), two microRNAs showed to be implicated: miR‐215‐5p and miR‐365a‐3p. These are preliminary but promising and novel results, as it is the first time, to our knowledge that microRNA profiles have been studied in the context of GMA treatment for IBD.
Population‐level effectiveness of pre‐exposure prophylaxis for HIV prevention among men who have sex with men in Montréal (Canada): a modelling study of surveillance and survey data
Authors: Doyle Carla M. , Milwid Rachael M. , Cox Joseph , Xia Yiqing , Lambert Gilles , Tremblay Cécile , Otis Joanne , Boily Marie‐Claude , Baril Jean‐Guy , Thomas Réjean , Blais Alexandre Dumont , Trottier Benoit , Grace Daniel , Moore David M. , Mishra Sharmistha , Maheu‐Giroux Mathieu 
Published: December 2023

AbstractIntroductionHIV pre‐exposure prophylaxis (PrEP) has been recommended and partly subsidized in Québec, Canada, since 2013. We evaluated the population‐level impact of PrEP on HIV transmission among men who have sex with men (MSM) in Montréal, Québec's largest city, over 2013–2021.MethodsWe used an agent‐based mathematical model of sexual HIV transmission to estimate the fraction of HIV acquisitions averted by PrEP compared to a counterfactual scenario without PrEP. The model was calibrated to local MSM survey, surveillance, and cohort data and accounted for COVID‐19 pandemic impacts on sexual activity, HIV prevention, and care. PrEP was modelled from 2013 onwards, assuming 86% individual‐level effectiveness. The PrEP eligibility criteria were: any anal sex unprotected by condoms (past 6 months) and either multiple partnerships (past 6 months) or multiple uses of post‐exposure prophylaxis (lifetime). To assess potential optimization strategies, we modelled hypothetical scenarios prioritizing PrEP to MSM with high sexual activity (≥11 anal sex partners annually) or aged ⩽45 years, increasing coverage to levels achieved in Vancouver, Canada (where PrEP is free‐of‐charge), and improving retention.ResultsOver 2013–2021, the estimated annual HIV incidence decreased from 0.4 (90% credible interval [CrI]: 0.3–0.6) to 0.2 (90% CrI: 0.1–0.2) per 100 person‐years. PrEP coverage among HIV‐negative MSM remained low until 2015 (<1%). Afterwards, coverage increased to a maximum of 10% of all HIV‐negative MSM, or about 16% of the 62% PrEP‐eligible HIV‐negative MSM in 2020. Over 2015–2021, PrEP averted an estimated 20% (90% CrI: 11%–30%) of cumulative HIV acquisitions. The hypothetical scenarios modelled showed that, at the same coverage level, prioritizing PrEP to high sexual activity MSM could have averted 30% (90% CrI: 19%–42%) of HIV acquisitions from 2015‐2021. Even larger impacts could have resulted from higher coverage. Under the provincial eligibility criteria, reaching 10% coverage among HIV‐negative MSM in 2015 and 30% in 2019, like attained in Vancouver, could have averted up to 63% (90% CrI: 54%–70%) of HIV acquisitions from 2015 to 2021.ConclusionsPrEP reduced population‐level HIV transmission among Montréal MSM. However, our study suggests missed prevention opportunities and adds support for public policies that reduce PrEP barriers, financial or otherwise, to MSM at risk of HIV acquisition.
An integrated docking and molecular dynamics simulation approach to discover potential inhibitors of activin receptor‐like kinase 1
Authors: Jairajpuri Deeba Shamim , Mohammad Taj , Hussain Afzal , Amir Samira , Fatima Urooj , AlAjmi Mohamed F. , Yadav Dharmendra Kumar , Hassan Md. Imtaiyaz 
Published: December 2023

AbstractActivin receptor‐like kinase 1 (ALK1) is a transmembrane receptor involved in crucial signaling pathways associated with angiogenesis and vascular development. Inhibition of ALK1 signaling has emerged as a promising therapeutic strategy for various angiogenesis‐related diseases, including cancer and hereditary hemorrhagic telangiectasia. This study aimed to investigate the potential of phytoconstituents as inhibitors of ALK1 using a combined approach of virtual screening and molecular dynamics (MDs) simulations. Phytoconstituents from the IMPPAT 2.0 database underwent virtual screening to identify potential inhibitors of ALK1. The compounds were initially filtered based on physicochemical parameters, following Lipinski's rules and the PAINS filter. Subsequently, compounds demonstrating high binding affinities in docking analysis were further analyzed. Additional assessments, including ADMET, PAINS, and PASS evaluations, were conducted to identify more potent hits. Through interaction analysis, a phytoconstituent, Candidine, exhibited appreciable affinity and specific interactions with the ALK1 active site. To validate the results, MD simulations and principal components analysis were performed. The MD simulations demonstrated that Candidine stabilized the ALK1 structure and reduced conformational fluctuations. In conclusion, Candidine shows promising potential as binding partners of ALK1. These findings provide a foundation for further exploration and development of Candidine as a lead molecule for therapeutic interventions targeting ALK1‐associated diseases.
Mpox outbreak control indicators used in Ontario, Canada: May 21–December 10, 2022
Authors: Zygmunt Austin , Saunders Andrea , Navarro Christine , Hasso Maan , Collinson Shannon 
Published: December 2023

AbstractSince May 2022, over 91 000 cases of mpox have been reported globally with the majority of cases occurring among adult males who identify as gay, bisexual, or men who have sex with men (gbMSM). Given the rapid emergence of the global mpox outbreak, many public health authorities did not have established mpox outbreak control indicators or criteria for declaring an mpox outbreak over. Expert consensus in Ontario, Canada, set thresholds for five key indicators of mpox outbreak control as follows: estimated number of currently infectious cases < 5; effective reproductive number < 1.0; doubling time > 42 days; weekly test positivity < 5%; and sporadic non‐gbMSM cases (i.e., female and pediatric cases). Once all indicators were achieved, a 52‐day period based on two incubation periods for mpox and a 10‐day reporting delay was employed to monitor for indicator stability. After all five indicators remained at expected levels, the mpox outbreak in Ontario was declared over on December 10, 2022. Despite current low levels of mpox activity globally, some jurisdictions may benefit from utilizing or modifying these outbreak control indicators during a future localized mpox outbreak.
Exploring the dynamics of the 2022 mpox outbreak in Canada
Authors: Milwid Rachael M. , Li Michael , Fazil Aamir , Maheu‐Giroux Mathieu , Doyle Carla M. , Xia Yiqing , Cox Joseph , Grace Daniel , Dvorakova Milada , Walker Steven C. , Mishra Sharmistha , Ogden Nicholas H. 
Published: December 2023

AbstractThe 2022 mpox outbreak predominantly impacted gay, bisexual, and other men who have sex with men (gbMSM). Two models were developed to support situational awareness and management decisions in Canada. A compartmental model characterized epidemic drivers at national/provincial levels, while an agent‐based model (ABM) assessed municipal‐level impacts of vaccination. The models were parameterized and calibrated using empirical case and vaccination data between 2022 and 2023. The compartmental model explored: (1) the epidemic trajectory through community transmission, (2) the potential for transmission among non‐gbMSM, and (3) impacts of vaccination and the proportion of gbMSM contributing to disease transmission. The ABM incorporated sexual‐contact data and modeled: (1) effects of vaccine uptake on disease dynamics, and (2) impacts of case importation on outbreak resurgence. The calibrated, compartmental model followed the trajectory of the epidemic, which peaked in July 2022, and died out in December 2022. Most cases occurred among gbMSM, and epidemic trajectories were not consistent with sustained transmission among non‐gbMSM. The ABM suggested that unprioritized vaccination strategies could increase the outbreak size by 47%, and that consistent importation (≥5 cases per 10 000) is necessary for outbreak resurgence. These models can inform time‐sensitive situational awareness and policy decisions for similar future outbreaks.
Finite element modeling of fracture compression by compression plates
Authors: Wee Hwabok , Spence Reid John , Lewis Gregory S. 
Published: December 2023

AbstractDynamic compression plating is a common type of fracture fixation used to compress between bone fragments. The quality of compression across the fracture is important for postoperative stability and primary bone healing. Compression quality may be affected by surgical variations in plate prebend, screw location, screw torque, fracture gap, and implant material. Computational modeling provides a tool for systematically examining these factors, and for visualizing the mechanisms involved. The purpose of this study was to develop a finite element model of dynamic compression plating that includes screw insertion under torque control, establish model credibility through sensitivity analyses and experimental validation, and use the model to examine the effects of surgical variables on fracture compression and postoperative stability. Model‐predicted compressive pressures had good agreement with corresponding synthetic bones experiments under a variety of conditions. Models demonstrated that introducing a 1.5 or 3 mm plate prebend (using a 4.5 mm narrow LCP plate) eliminated gapping at the far cortex, which is consistent with clinical recommendations. However, models also revealed that plate prebend led to sharp decreases in fracture compressive force, exceeding 80% in some cases. A 1.5 mm plate prebend resulted in the most uniform pressures across the fracture. Testing of a simplified model form used in previous computational modeling studies showed large inaccuracies for constructs with plate prebend. This study provides the first experimentally validated computational models of dynamic compression plate fracture fixation, and reveals important effects of plate prebend and fracture gap on fracture compression quality.
Examination of race‐based traumatic stress symptom networks in Black adults in the United States: A network analysis
Authors: Dieujuste Nathalie , Mekawi Yara , Doom Jenalee R. 
Published: December 2023

AbstractIn the United States, racism is theorized to exert its negative effects on Black individuals’ mental health by triggering a response known as “race‐based traumatic stress” (RBTS), a multidimensional construct comprising seven clusters of symptoms that can occur following exposure to race‐based traumatic events (e.g., racial discrimination, racist incidents): depression, intrusion, anger, hypervigilance, physical symptoms, (low) self‐esteem, and avoidance. However, little is known about which symptoms and clusters are strongest and most influential in the maintenance of RBTS. Network analysis is a powerful tool for understanding the etiology of traumatic stress, but it has not yet been applied to the examination of this construct. The present study aimed to identify the symptoms most central to RBTS and examine associations between symptoms and symptom clusters. Participants (N = 1,037) identified as Black, and lived in the United States (Mage = 45.12 years, range: 18–82 years) and completed the Race‐Based Traumatic Stress Symptom Scale–Short Form (RBTSSS‐SF). Regularized partial correlation networks were estimated using R/RStudio. The cluster‐ and item‐level networks demonstrated adequate centrality stability, CS = .44. The depression and physical symptoms clusters were the most central nodes in the cluster network. Feelings of meaninglessness, experiencing mental images of the event, and physical trembling were the most central items within the item‐level network. These findings offer insights and implications for assessing and treating symptoms of RBTS in Black adults in the United States who are exposed to race‐based traumatic events.
Corrigendum to “Improvements on Sawyer‐type estimates for generalized maximal functions”
Authors: Berra Fabio , Carena Marilina , Pradolini Gladis 
Published: December 2023

AbstractThe purpose of this note is to correct a mixed estimate involving the generalized maximal function , when Φ is a Young function satisfying certain properties. The family considered include type functions. Although the obtained estimates turn out to be slightly different, they are still good extensions of mixed inequalities for the classical Hardy–Littlewood maximal operators corresponding to the power functions , with . They also allow us to derive the boundedness properties of between Lebesgue spaces by using interpolation techniques related to endpoint estimates of modular type.
Significant alteration of protein profiles in a mouse model of polycystic ovary syndrome
Authors: Meng Bin , Yang Xiaoning , Luo Shiwei , Shen Chong , Qi Jia , Zhang Haifeng , Li Yandong , Xue Ying , Zhao Juan , Qu Pengxiang , Liu Enqi 
Published: December 2023

AbstractPolycystic ovary syndrome (PCOS) is an endocrine disorder, affecting women of child‐bearing age, and the incidence rate is growing and assuming epidemic proportions. The etiology of PCOS remains unknown and there is no cure. Some animal models for PCOS have been established which have enhanced our understanding of the underlying mechanisms, but omics data for revealing PCOS pathogenesis and for drug discovery are still lacking. In the present study, proteomics analysis was used to construct a protein profile of the ovaries in a PCOS mouse model. The result showed a clear difference in protein profile between the PCOS and control group, with 495 upregulated proteins and 404 downregulated proteins in the PCOS group. The GO term and KEGG pathway analyses of differentially expressed proteins mainly showed involvement in lipid metabolism, oxidative stress, and immune response, which are consistent with pathological characteristics of PCOS in terms of abnormal metabolism, endocrine disorders, chronic inflammation and imbalance between oxidant and antioxidant levels. Also, we found that inflammatory responses were activated in the PCOS ovarium, while lipid biosynthetic process peroxisome, and bile secretion were inhibited. In addition, we found some alteration in unexpected pathways, such as glyoxylate and dicarboxylate metabolism, which should be investigated. The present study makes an important contribution to the current lack of PCOS ovarian proteomic data and provides an important reference for research and development of effective drugs and treatments for PCOS.