bluuebunny/crossref_metadata_2025_split huggingface dataset:
An analysis of students’ perceptions of teachers’ questioning in secondary biology classrooms
Authors: Zhang Zhongyan , Chen Xiaoge 
Published: February 2024

AbstractSecondary students’ perceptions of teachers’ questioning have not been clarified in the literature, but these perspectives are invaluable as they help to make sense of what students notice about teachers’ questioning and enhance teachers’ questioning skills. In this study, eight students from three schools in Xi’an City, aged 12 to 16, were interviewed individually with teaching episodes and student drawings used to elicit in-depth perspectives during those interviews. The findings indicated that students demonstrated sophisticated and thoughtful reflections on open and closed questions, on how teachers used questions differently in two types of classes, on scenario-based questions that asked them to think from the perspective of a scientist, and on other aspects of teacher questioning. The students expressed a preference for scenario-based questions and valued questioning that demonstrated teacher power and authority less and supported student engagement in knowledge construction. These findings have several important implications for teaching and learning and teachers’ professional development: for example, using students’ views to encourage teachers to think about scenario-based questions.
Risk of atrial fibrillation in patients with multiple myeloma: what is known and directions for future study
Authors: Fu Ting , Chen Yuxiao , Lou Lian , Li Zhihang , Shi Wen , Zhang Xuan , Yang Jian 
Published: February 2024

Abstract
Background
Multiple myeloma (MM) is a prevalent hematological tumor, and recent clinical data have highlighted the significance of atrial fibrillation (AF) as a crucial complication affecting the prognosis of MM. This review aims to consolidate findings from published clinical studies, focusing on the epidemiological characteristics of AF in MM patients and the associated risks arising from MM treatments such as autologous hematopoietic stem cell transplantation, proteasome inhibitors, and immunomodulatory agents.

Main body
While existing data partially demonstrate a strong correlation between MM and AF, further clinical studies are necessary to comprehensively investigate their association. These studies should encompass various aspects, including the risk of AF resulting from MM treatment, the impact of AF-induced embolic events and heart failure on MM prognosis, as well as the influence of AF management methods like catheter ablation or left atrial appendage closure on MM prognosis.

Conclusions
The supplementation of future data will provide more precise guidance for managing MM patients. By incorporating information regarding AF risk associated with MM treatment and examining the effects of AF management strategies on MM prognosis, healthcare professionals can enhance their decision-making process when caring for individuals with MM.
Eligibility for hematopoietic stem cell transplantation in a cohort of children with sickle cell disease: a single-center report
Authors: Salama Khaled , Allam Asmaa F. , Selim Yasmeen M. M. 
Published: February 2024

Abstract
Background
Hematopoietic stem cell transplantation (HSCT), is the only currently available curative option for SCD. Yet, the eligibility of SCD patients for HSCT is always limited by the significant associated toxicity and lack of suitable donors. At Cairo University’s pediatric hematology outpatient clinic, we aimed to determine hematopoietic stem cell transplantation (HSCT) candidates among a sickle cell disease (SCD) cohort, estimate the number of possible donors, and analyze the differences between patients with and without an HSCT indication.

Methods
This study was a cross-sectional analytic study including 128 SCD children. Their demographic, clinical, and laboratory profiles, total number, and number of siblings with SCD were obtained from their medical records.

Results
Sixty-nine (53.9%) had at least one HSCT indication. Recurrent severe pain episodes despite hydroxyurea were the most common indication. Hemoglobin was lower, while reticulocyte count, serum ferritin, and aspartate aminotransferase were higher in HSCT candidates (p value < 0.001). Additionally, the prevalence of splenomegaly, the dose of hydroxyurea, and the number of transfusions were noticeably higher in HSCT candidates (p value = 0.013, 0.005, and < 0.0001 respectively). Among those indicated for HSCT; 75.3% had at least one healthy sibling who might be a potential donor.

Conclusion
More than half were eligible for HSCT which should always be considered to provide a possible cure for the disease. Of the transplantation-eligible cases, about two-thirds had at least one healthy sibling who might potentially serve as a donor. Those meeting the requirements for HSCT eligibility should routinely undergo human leukocyte antigen (HLA) testing of their unaffected siblings.
The inter-relationship of the triad: osteoporosis, fracture risk, and obesity—a longitudinal multicenter analysis by the Egyptian Academy of Bone Health
Authors: El Miedany Yasser , El Gaafary Maha , Mahran Safaa , Gadallah Naglaa , Azim Atef Abdel , Hassan Waleed , Abu-Zaid Mohammed Hassan , Shalaby Radwa H. , Tabra Samar abd Alhamed , Elwakil Walaa 
Published: February 2024

Abstract
Purpose
To assess the relationship between the triad of obesity, fracture risk factors, and osteoporosis and its impact on fragility fractures.

Results
Osteoporosis was least prevalent (p < 0.001) among the obese patients in comparison to overweight and normal body mass index patients. On the other hand, history of risk of falling as well as history of fall(s) in the last year, sarcopenia, and functional disability were significantly more prevalent (< 0.01, 0.05, and 0.05 respectively) among the obese patient cohort.

Conclusion
Obesity was found to be associated with higher bone mineral density of the hip, lumbar spine, and distal forearm. This was significantly different in post-menopausal women, but not in men. Covariates such as sarcopenia, falls risk, and functional disability play an important factor in making the patient at high risk and prone to develop a fragility fracture.
Estimating the impact on maize production by the weed
Parthenium hysterophorus
in Pakistan
Authors: Naderi Ruhollah , Ali Kazam , Rehman Abdul , Rasmann Sergio , Weyl Philip 
Published: February 2024

Abstract

Parthenium hysterophorus
L. (Asteraceae) is an aggressive annual herbaceous weed which causes severe yield losses on a global scale. However, the precise impact of this weed in several countries is not yet known. To assess the impact of
P
.
hysterophorus
on maize crop losses in Pakistan, a 2 year field experiment was carried out at the CABI Rawalpindi campus in 2019 and 2020. Yield was measured on maize plants planted along with different densities (0, 1, 2, 4, 8, and 16 plants per m
2
) of
P
.
hysterophorus
. The trial was laid in a randomized complete block design with five replicates per density each year. The highest maize seed yield was obtained in weed-free plots (4256.5 ± 118 kg ha
−1
), while maize yield at weed infestation levels of 1, 2, 4, 8 and 16 plants m
−2
was reduced by 14, 22, 29, 38 and 46%, respectively, compared to weed free plots. In the light of these findings, to reduce yield losses to non-significant levels it is proposed to reduce
P
.
hysterophorus
densities below 2 plants per m
2
in maize fields.
Prevalence and predictors of insomnia and its treatment-seeking among older adults in India
Authors: Pradhan Manas Ranjan , Saikia Daisy 
Published: February 2024

Abstract
Background
Insomnia is a serious health problem among older adults and, if untreated, is linked to a high morbidity rate and decreased quality of life. There is limited empirical evidence on Insomnia and its treatment-seeking exclusively among older adults (60 plus years) using representative data in India. This study assesses the prevalence and predictors of Insomnia and its treatment-seeking among older adults.

Methods
Data gathered through the nationally-representative Longitudinal Ageing Study in India (LASI); Wave 1 (2017-18) was used for the analysis. Specifically, information from older adults aged 60 and above for whom complete information on insomnia was available (n- 31,464) was considered for the analysis. Binary logistic regression was used to check the adjusted effects of insomnia’s socio-demographic and economic predictors and its treatment-seeking status. Stata was used for the data analysis with a 5% significance level.

Results
37% of older adults had insomnia. Increasing age, female gender, living without a spouse, illiteracy, chronic health conditions, nutritionally underweight, physically inactive status, lack of exposure to mass media, Hindu religion, non-tribal status, and rural residence were significantly associated with insomnia. 3% of older adults sought treatment for insomnia. Not seeking treatment for insomnia was associated with male gender, exposure to mass media, physical activity, lack of chronic health issues, tribal status, living in a rural area, and being economically disadvantaged.

Conclusions
A sizable number of older adults have insomnia, and the prevalence varies by their socioeconomic, demographic, and health status. Many modifiable risk factors like low education, chronic health conditions, smoking, being underweight, physical inactivity, and lack of exposure to mass media are identified. Treatment-seeking for Insomnia is further inadequate, enhancing the older adult’s vulnerability to various morbidities. Policy and program intervention to raise awareness about insomnia, including early identification and pharmacological and non-pharmacological treatment, will ensure better health and welfare of older adults. Estimations are based on self-report questionnaires; therefore, the possibility of recall bias and under-reporting cannot be ignored. Moreover, the estimation of insomnia may vary depending on various clinical definitions. However, a large sample size from a recent nationally representative survey with a robust sampling design is the strength of this study.
Genetic and Epigenetic Landscape for Drug Development in Polycystic Ovary Syndrome
Authors: Chen Yi , Wang Guiquan , Chen Jingqiao , Wang Congying , Dong Xi , Chang Hsun-Ming , Yuan Shuai , Zhao Yue , Mu Liangshan 
Published: February 2024

Abstract
The treatment of polycystic ovary syndrome (PCOS) faces challenges as all known treatments are merely symptomatic. The US Food and Drug Administration has not approved any drug specifically for treating PCOS. As the significance of genetics and epigenetics rises in drug development, their pivotal insights have greatly enhanced the efficacy and success of drug target discovery and validation, offering promise for guiding the advancement of PCOS treatments. In this context, we outline the genetic and epigenetic advancement in PCOS, which provide novel insights into the pathogenesis of this complex disease. We also delve into the prospective method for harnessing genetic and epigenetic strategies to identify potential drug targets and ensure target safety. Additionally, we shed light on the preliminary evidence and distinctive challenges associated with gene and epigenetic therapies in the context of PCOS.
Noninsulinoma Pancreatogenous Hypoglycemia Syndrome in a Patient With 1p36 Deletion Syndrome
Authors: Auckley Elizabeth Diane , Arosemena Marilyn , Philipson Louis H 
Published: February 2024

Abstract
The 1p36 deletion syndrome involves a phenotypic presentation that includes central nervous system, cardiac, and craniofacial anomalies. We report the case of a 21-year-old female patient with 1p36 deletion syndrome who was found to have noninsulinoma pancreatogenous hypoglycemia syndrome (NIPHS) after hospitalization for persistent falls. On admission, vital signs were normal and physical examination revealed a thin, nonverbal patient. During hospitalization and prolonged fasting (14-18 hours), she persistently developed hypoglycemia (serum glucose nadir 57 mg/dL [3.2 mmol/L] [70-100 mg/dL; 3.9-5.6 mmol/L]). Subjective symptoms of hypoglycemia were not confirmed due to patient's cognitive impairment. Hypoglycemic events continued despite feeding and dextrose-containing fluids. Further workup included a critical sample that revealed a serum glucose 59 mg/dL (3.3 mmol/L), insulin 20.6 μIU/mL (123.6 pmol/L [5-15 μIU/mL; 30.0-90 pmol/L]), proinsulin 33 pmol/L (3.6-22 pmol/L), C-peptide 1.74 ng/mL (0.58 nmol/L [0.8-3.85 ng/mL; 0.27-1.28 nmol/L]) and beta-hydroxybutyrate &lt; 1.04 mg/dL (&lt; 0.10 mmol/L; [&lt; 4.2 mg/dL; &lt; 0.4 mmol/L]). Insulin antibodies were negative. After confirmed insulin-mediated hypoglycemia, imaging studies followed. Pancreatic protocol abdominal computed tomography (CT), Ga-68 DOTATATE PET/CT scan, and endoscopic ultrasound found no pancreatic mass. Selective arterial calcium stimulation test showed a two-fold increase in insulin levels in 3/3 catheterized pancreatic territories. The patient started octreotide injections with resolution of hypoglycemia and was discharged on monthly lanreotide injections. To our knowledge, this is the first case reported of noninsulinoma pancreatogenous hypoglycemia in a patient with 1p36 deletion syndrome.
The Relationship of Spinal Anesthesia Dosing Based on Thecal Sac Area to Anesthetic Failure in Lumbar Surgery
Authors: Patel Jainith , Karimi Helen , Olmos Michelle , Wiepert Liana , Kanter Matthew , Hernandez Nicholas S. , Frerich Jason M. , Riesenburger Ron I. , Kryzanski James 
Published: February 2024

BACKGROUND AND OBJECTIVES:
Greater thecal sac volumes are associated with an increased risk of spinal anesthesia (SA) failure. The thecal sac cross-sectional area accurately predicts thecal sac volume. The thecal sac area may be used to adjust the dose and prevent anesthetic failure. We aim to assess the rate of SA failure in a prospective cohort of lumbar surgery patients who receive an individualized dose of bupivacaine based on preoperative measurement of their thecal sac area.

METHODS:
A total of 80 patients prospectively received lumbar spine surgery under SA at a single academic center (2022-2023). Before surgery, the cross-sectional area of the thecal sac was measured at the planned level of SA injection using T2-weighted MRI. Patients with an area <175 mm2, equal to or between 175 and 225 mm2, and >225 mm2 received an SA injection of 15, 20, or 25 mg of 0.5% isobaric bupivacaine, respectively. Instances of anesthetic failure and adverse outcomes were noted. Incidence of SA failure was compared with a retrospectively obtained control cohort of 250 patients (2019-2022) who received the standard 15 mg of bupivacaine.

RESULTS:
No patients in the individualized dose cohort experienced failure of SA compared with 14 patients (5.6%) who experienced failure in the control cohort (P = .0259). The average thecal sac area was 187.49 mm2, and a total 28 patients received 15 mg of bupivacaine, 42 patients received 20 mg of bupivacaine, and 10 patients received 25 mg of bupivacaine. None of the patients experienced any adverse outcomes associated with SA. Patients in the individualized dose cohort and control cohort were comparable and had a similar distribution of lumbar procedures and comorbidities.

CONCLUSION:
Adjusting the dose of SA according to thecal sac area significantly reduces the rate of SA failure in patients undergoing lumbar spine surgery.
Experimental evidence that EPA and DHA are dietary requirements in a migratory shorebird, but they do not affect muscle oxidative capacity
Authors: Dick Morag F. , Hobson Keith A. , Guglielmo Christopher G. 
Published: February 2024

ABSTRACT
Dietary n-3 long chain polyunsaturated fatty acids (LCPUFAs) are hypothesized to be natural doping agents in migratory shorebirds, enabling prolonged flight by increasing membrane fluidity and oxidative capacity of the flight muscles. Animals can obtain n-3 LCPUFAs from the diet or by conversion of dietary α-linolenic acid, 18:3 n-3. However, the capacity to meet n-3 LCPUFA requirements from 18:3 n-3 varies among species. Direct tests of muscle oxidative enhancement and fatty acid conversion capacity are lacking in marine shorebirds that evolved eating diets rich in n-3 LCPUFAs. We tested whether the presence and type of dietary fatty acids influence the fatty acid composition and flight muscle oxidative capacity in western sandpipers (Calidris mauri). Sandpipers were fed diets low in n-3 PUFAs, high in 18:3 n-3, or high in n-3 LCPUFAs. Dietary fatty acid composition was reflected in multiple tissues, and low intake of n-3 LCPUFAs decreased the abundance of these fatty acids in all tissues, even with a high intake of 18:3 n-3. This suggests that 18:3 n-3 cannot replace n-3 LCPUFAs, and dietary n-3 LCPUFAs are required for sandpipers. Flight muscle indicators of enzymatic oxidative capacity and regulators of lipid metabolism did not change. However, the n-3 LCPUFA diet was associated with increased FAT/CD36 mRNA expression, potentially benefitting fatty acid transport during flight. Our study suggests that flight muscle lipid oxidation is not strongly influenced by n-3 PUFA intake. The type of dietary n-3 PUFA strongly influences the abundance of n-3 LCPUFAs in the body and could still impact whole-animal performance.
Cost-Effective Acquisition of First-Party Data for Business Analytics
Authors: Liu Xiaoping , Li Xiao-Bai 
Published: February 2024

Customer data acquisition is an important task in data-driven business analytics. Recently, there has been a growing interest in the effective use of an organization’s internal customer data, also known as first-party data. This work studies the acquisition of new data for business analytics based on first-party data resource. We address issues related to both acquisition cost and data quality. To reduce acquisition cost, we consider using auction-based methods, such as the generalized second price (GSP) auction, for acquiring data with differential prices for different customers. We find that the GSP-based data acquisition method incurs a lower cost and/or achieves a higher response rate than fixed price methods. To maximize data quality, we propose novel optimization models for different data acquisition methods and data quality measures. The proposed models maximize the quality of the acquired data while satisfying budget constraints. We derive and discuss the solutions to the optimization models analytically and provide managerial insights from the solutions. The proposed approach is effective in increasing customer responses, reducing selection bias, and enabling more accurate estimation and prediction for business analytics. The results of the experimental evaluation demonstrate the advantage of the proposed approach over existing data acquisition methods. History: Accepted by Ram Ramesh, Area Editor for Data Science and Machine Learning. Supplemental Material: The software that supports the findings of this study is available within the paper and its Supplemental Information ( https://pubsonline.informs.org/doi/suppl/10.1287/ijoc.2022.0037 ) as well as from the IJOC GitHub software repository ( https://github.com/INFORMSJoC/2022.0037 ). The complete IJOC Software and Data Repository is available at https://informsjoc.github.io/ .
Exact Method for Production Hub Location
Authors: Wu Tao 
Published: February 2024

This study proposes a production hub location (PHL) problem that integrates the classical multiplant lot-sizing and hub location problems. The PHL problem is to determine the location of production facilities, lot-sizing, inventory, hub location, and the distribution of multiple commodities from plants to customers, with an objective to minimize the total production, setup, inventory, hub operating, and transportation costs. The PHL problem applies to manufacturing companies that either have built a hub-and-spoke distribution network or are accessible to such a network through collaborations with other third-party logistics companies. Because the PHL problem is [Formula: see text]-hard, we propose an exact method that integrates dynamic programming and Benders decomposition (DPBD) for solving the problem. The DPBD method is enhanced by exploring several problem properties, such as a multicut reformulation, the generation of Pareto-optimal cuts, a two-stage hub elimination and restoration procedure, and the inclusion of a novel heuristic procedure. We compare the PHL model with several related models theoretically and computationally with newly created benchmark instances. The computational results indicate that the proposed model can reduce the total costs and facilitate better network designs and system decisions, highlighting the value of an integrated approach. We also provide managerial insights into the benefits of integration and show the efficiency of the DPBD method through an extensive number of computational tests. History: Accepted by Andrea Lodi, Area Editor for Design and Analysis of Algorithms—Discrete. Supplemental Material: The online supplement is available at https://doi.org/10.1287/ijoc.2023.0339 .
Analysis of modular taper fractures of the revision hip stem Prevision and comparison of the original and current taper design
Authors: Dreyer Lutz , Bader Christian , Flörkemeier Thilo , Wagner Michael 
Published: February 2024

AimsThe risk of mechanical failure of modular revision hip stems is frequently mentioned in the literature, but little is currently known about the actual clinical failure rates of this type of prosthesis. The current retrospective long-term analysis examines the distal and modular failure patterns of the Prevision hip stem from 18 years of clinical use. A design improvement of the modular taper was introduced in 2008, and the data could also be used to compare the original and the current design of the modular connection.MethodsWe performed an analysis of the Prevision modular hip stem using the manufacturer’s vigilance database and investigated different mechanical failure patterns of the hip stem from January 2004 to December 2022.ResultsTwo mechanical failure patterns were identified: fractures in the area of the distal fluted profile (distal stem fracture) and failure of the modular taper (modular fracture). A failure rate of 0.07% was observed for distal stem fracture, and modular fracture rates of 1.74% for the original and 0.013% for the current taper design.ConclusionA low risk of mechanical failure for both fracture types was observed compared to other known complications in revision hip arthroplasty. In addition, the data show that a design change did significantly reduce the risk of a modular fracture.Cite this article: Bone Joint J 2024;106-B(2):151–157.