bluuebunny/crossref_metadata_2025_split huggingface dataset:
Ensemble Machine Learning Prediction Model for Ocular Refraction Using Partial Interferometry Measurements in Childhood
Authors: Kim Sa Ra , Kang Dong Hyun , Choe Gon Soo , Kim Dae Hee 
Published: February 2024

Abstract

To develop an ensemble machine learning prediction model for ocular refraction in childhood using partial interferometry measurements, Age, sex, cycloplegic refraction, and partial interferometry data collected within one month were obtained from patients aged 5 to 16 years. Four ensemble regression models were used to develop prediction models of spherical equivalents (SE) from the data. Root mean squared error (RMSE) was used to compare the accuracy among the models. That was compared with that of a previously developed multiple linear regression model.
4156 eyes from 1965 patients (50.3% female) were included. Mean age was 8.4 ± 2.3 years and mean SE was-1.01 ± 2.94 diopters(D). Mean axial length(Axl) was 23.63 ± 1.41 mm and mean keratometry reading of flat and steep axis was 43.58 ± 1.40 D. Developed models had accuracy of RMSE 0.800 to 0.829 D, which was superior to that of the conventional model (1.213 D). Simulations showed that female was associated more with myopia than that of male. Long eyes showed an increase in the myopic refraction per Axl.
Refractive errors can be calculated in the childhood with ocular biometric parameters using new models. Moreover, the models could simulate hypothetical relationships between ocular parameters and SE.
Dietary sucrose, sucralose and probiotic sweetener isomaltooligosaccharide divergently affect exercise induced weight loss and its associated skeletal muscle metabolism
Authors: Shi Lin , Liu Yuan , Duan Yongchang , Liu Tianqi , Zhang Baobao , Zhu Wanyu , Kang Jie , Zhang Kunru 
Published: February 2024

Abstract
Dietary sweeteners are highly favored by obese people who desire to lose weight and have been considered beneficial for weight maintenance and glucose control, but little is known whether they could affect exercise induced weight loss efficacy and its associated perturbations in skeletal muscles, a key organ playing critical roles glucose homeostasis. In the present study, we found daily drinking sucrose- and sucralose-sweetened water failed to influence the effect of exercise on weight reduction of high-fat-high-sucrose (HFHF) induced obese mice, but remarkably attenuated exercise induced improvements on skeletal muscle morphology, anti-fatigue capacity and glucose metabolism. Probiotic sweetener isomaltooligosaccharide (IMO) augmented beneficial effects of exercise on improving glucose metabolism and skeletal muscle morphology. Skeletal muscle transcriptomics analysis revealed that exercise regulated genes involved in fatty acid metabolism, insulin resistance, inflammation and mTOR signaling pathways. Drinking sucrose and sucralose increased mRNA expressions of Yap, IL-6, TNF-α, Fis1, Cytc, Myh2, Myh4, and protein expressions of IL-6, mTOR, FABP4 while lowered HIF1α, demonstrating their detrimental effects on counteracting exercise induced improvements in muscular functions and fatty acid metabolism. Consistent results were also validated in C2C12 skeletal muscle cells in vitro. Notably, we found that the exercised mice may be resistant to the excessive weight regain and its impaired glucose metabolism. For the first time, our study proved that both sucrose and sucralose could attenuate protection of exercise against muscular inflammation during the weight regain following weight loss. Collectively, our results reinforce that daily drinking of sucrose and sucralose-sweetened water counteracted exercise induced improvements on skeletal muscle metabolism and could be dietary factors favouring weight regain, while IMO to some extent synergistically augmented such benefits.
Skeletal muscle lncRNA profile associated with fatty acids in beef cattle
Authors: Salatta Bruna Maria , Muniz Maria Malane Magalhães , Fonseca Larissa Fernanda Simielli , Mota Lucio Flavio Macedo , Teixeira Caio de Souza , Frezarim Gabriela Bonfá , Serna-García Marta , Silva Danielly Beraldo dos Santos , Pereira Angélica Simone Cravo , Baldi Fernando , de Albuquerque Lucia Galvão 
Published: February 2024

Abstract
This study aimed to identify differentially expressed (DE) long non-coding RNAs (lncRNAs) in muscle tissue of Nellore cattle clustered by their fatty acid profile. Longissimus thoracis muscle samples from 48 young bulls were used to quantify fatty acid (FA) (myristic, palmitic, stearic, oleic, linoleic, conjugated linoleic (CLA), α-linolenic and the groups of saturated fatty acids (SFA), monounsaturated (MUFA), polyunsaturated (PUFA), ω3, ω6, PUFA/SFA ratio and ω6/ω3) and to generate RNA-Sequencing data for transcriptomic analyses. The K-means analysis was used to classify the 48 animals into three clusters based on their FA patterns. The C1 had significantly (p ≤ 0.05) higher PUFA, ω3, ω6, linoleic and α-linolenic content than C2 and C3. The proportion of MUFA, CLA and oleic in the C2 and C3 were significantly (p ≤ 0.05) higher in relation to C1, while C3 had significantly (p ≤ 0.05) higher proportions of ω6/ω3, SFA, myristic, palmitic and stearic proportion than C1 and C2. DE analyses were performed on three different comparisons, C1 vs. C2, C1 vs. C3 and C2 vs. C3, and 25, 28 and 22 DE lncRNAs (fold change > | 2 |, p-value < 0.01 and false discovery rate (FDR) < 0.05) were found, respectively. For C1 vs. C2 comparison, a new transcript “lncRNA_16456.3” was found and was interacted with the genes FAM126A (Family with sequence similarity 126 member A) and IL6 (Interleukin-6). These genes were enriched by GO biological function terms related to cellular response to lipid pathway. For the C1 vs. C3 comparison, the lncRNA "lncRNA_13894.1" interacting with the BNIP3 gene (BCL2/Adenovirus E1B 19 kDa protein-interacting protein 3) was enriched by GO biological function terms related to fat cell differentiation. For the C2 vs. C3 comparison, a new transcript “lncRNA_16618.6” interacted with genes involved in G protein-coupled receptors (GPCRs). Those genes play a crucial role in regulating lipolysis mediated by the cAMP signaling pathway and may be contributing to a higher PUFA fatty acid content in beef. For the three comparisons: C1 vs. C2, C1 vs. C3, and C2 vs. C3, the identified lncRNAs, including genic and intergenic (lincRNA were associated with genes affecting immune response, energy metabolism, lipid and FA metabolism, whose seem to play an essential role in the physiological processes related to meat quality. These findings provide new insights to better understand the biological mechanisms involved in gene regulation of FA composition in beef. This could be valuable for further investigation regarding interaction between lncRNAs and mRNAs and how these interactions may affect meat quality.
Update on the taxonomy of Clavulina in China II: description of four new species from Hainan Island.
Authors: Deng Peng Tao , Liu Xiangfen , Yan Jun , Chen Zuo-Hong , Zhang Ping 
Published: February 2024

Abstract

Four new species of Clavulina are described from specimens collected in the tropical rainforests of Hainan Island, China.Molecular phylogenetic analyses based on concatenated ITS+LSU+RPB2 sequences and morphological characters support the placement of these accessions within the genus Clavulina and their recognition as new species. Accordingly, Clavulina hainanensis sp. nov., C. pallidorosea sp. nov., C. tomentosa sp. nov., and C. eburnea sp. nov. are described and illustrated. We provide photographs, line drawings, and DNA sequences of the new species, and a key to all known Clavulina species in China. Holotypes of the new species are deposited in the Mycological Herbarium of Hunan Normal University (MHHNU).
Immune Response to COVID-19 Vaccination in Frail Patients
Authors: Liao Shao bing , Wu Liang , Li Shangjie , zheng Xueting , Xu Jiahao , Zhang Xiaoxia , Yin Mingjuan , Ni Jindong , Zhang Qiaoli , Yu Zuwei 
Published: February 2024

Abstract

Objective
This study sought to examine the immune response to COVID-19 vaccination in frail patients and the associated role of inflammatory factors in immune response to COVID-19 vaccination.
Methods
A prospective cohort study design was used to assess the effects of the COVID-19 vaccine in non-frail and frail elderly individuals following a frailty assessment. The immune response between the two elderly populations were compared using Poisson regression modeling. A nested case-control study in an elderly population was also performed, differentiating the case group from the control group based on COVID-19 vaccine efficacy. A logistic regression analysis was employed to examine the correlation between frailty-related inflammatory factors and COVID-19 vaccine efficacy.
Results
A total of 920 individuals participated in the study, with 598 (65%) belonging to the non-frail group and 322 (35%) to the frail group. The frail group exhibited a lower seropositivity rate than the non-frail group after adjusting for age, amount of vaccination shots, and vaccination type using modified Poisson regression (RR = 0.929, 95% CI: 0.891 − 0.968; P < 0.05). The Logistic regression analysis revealed that the positive group had lower levels of CXCL10 (OR = 0.951; CI: 0.907 − 0.997; P < 0.05) after correcting for covariate weakening.
Conclusion
The present findings indicate that frailty may have a negative impact on COVID-19 vaccine efficacy. The concentration of CXCL10 may affect COVID-19 vaccine efficacy by altering the inflammatory levels in elderly frail patients.
Real-world data on treatment regimen and medical use among patients in hemophilia B in Korea
Authors: Park Young Shil , Park Ji Kyoung , Park Jeong A , Beak Hee Jo , Lee Jae Hee , You Chur Woo , Lyu Chuhl Joo , Choi Eun Jin 
Published: February 2024

Abstract
Background
We aimed to investigate the real-world treatment status such as treatment regimen, bleeding events, and drug dose of patients with hemophilia B in South Korea.
Methods
In this retrospective chart review study, we collected the data of hemophilia B patients from the 8 university hospitals. Demographic and clinical data, treatment data such as regimen and injection number, factor IX concentrate dose, and bleeding data were reviewed. Descriptive analyses were done with annual data of 2019, 2020, and 2021, respectively as well as consecutive 3 years.
Results
150 hemophilia B patients with medical records between January 1, 2019 and December 31, 2021 were collected. Among those, 72 (48.0%) was severe, 47 (31.3%) was moderate, 28 (18.7%) was mild. The results showed approximately 2 times more patients receiving prophylaxis therapy than on-demand therapy, with 66.1% patients receiving prophylaxis therapy in 2019, 64.9% in 2020, and 72.1% in 2021. Annualized bleeding rate was observed to be 2.2 (±3.1) in 2019, 1.8 (±3.0) in 2020, and 1.8 (±2.9) in 2021 among patients with prophylaxis regimens. For factor IX concentrate doses, patients with prophylaxis regimens received an average of 41.6 (±11.9) IU/Kg/Injection in 2019, 45.7 (±12.9) IU/Kg/Injection in 2020, and 60.1 (±24.0) IU/Kg/Injection in 2021.
Conclusions
In the real-world, prophylaxis is more prevalent than reported. Based on the insights gained from current real-world clinical evidence, it is expected that patients' unmet medical needs can be identified and physicians can consider the patient's situation and actively manage hemophilia B with more effective treatment strategies.
A Comparative Study of Standard and Long-Short Addendum Helical Gear Pair Performance: Multi-Objective Optimization Using Genetic Algorithm
Authors: Akkasaligara Sathyanarayana Achari , Daivagna Umesh M , Banakar Prashanth , Paradeshi Lokesh B 
Published: February 2024

Abstract
This study provides insights into the effectiveness of the genetic algorithm-based optimization process for long-short addendum helical gear pairs, aiming to balance the specific sliding ratio during approach and recess phases while concurrently increasing the load-carrying capacity to the pinion. The iterative process, undertaken with an appropriately chosen population size for the two variables (x1 and x2) over the specified maximum number of generations, consistently yields reliable results, highlighting the algorithm's efficiency and convergence. Visual representations highlight significant addendum modifications, showcasing the algorithm's adaptability to meet specific design criteria for long-short addendum helical gear pairs. The study further explores the reduction in tooth root stress and contact stress of standard helical gears after optimization, determined through finite element analysis using ANSYS software. Additionally, the effects of addendum modification on helix angle and total volume of the gear are examined in detail. A numerical approach is established to calculate the cross-sectional area of the single helical gear tooth in the transverse plane and the total volume of the gear for both standard and optimized long-short addendum helical gears. This approach is validated with real-time CAD models, confirming its accuracy by yielding identical values. In summary, the research underscores the effectiveness of the genetic algorithm-based optimization process for long-short addendum helical gear pairs, with a dual focus on balancing specific sliding ratios and increasing the load-carrying capacity to the pinion, offering valuable insights for advancing such gear configurations in engineering applications.
E2GCO: Event-driven Eye-Gaze-Controlled Operation for Smartphone Interaction
Authors: Liang Dong , Yan Shaoming , Ju Yuanliang , Quan Rong , Tu Huawei 
Published: February 2024

Abstract

Existing gaze-based smartphone interaction methods generally need the auxiliary of hand motions to realize control, and most of them can achieve only simple control operations, which are far from practical smartphone control. To this end, we propose a novel eye-gaze-based smartphone interaction method named Event-driven Eye-Gaze-Controlled Operation ($E^2GCO$), which can realize comprehensive smartphone control operations just using human eyes and gazes. We designed four pairs of eye-gaze-based interaction actions that are easy to implement and distinguish, based on which $E^2GCO$ can control all kinds of smartphone pages. Before the interaction, an anti-jitter strategy-based gaze estimation method is exploited to solve the jitter problem of human eye fixation and detect both accurate and stable human gaze locations on smartphone screens, even when the users are moving. The interaction can be executed more accurately based on the stable and accurate gaze locations. In addition, the event camera technology is introduced in $E^2GCO$ to significantly decrease its power consumption, making $E^2GCO$ more power-efficient to deploy on smartphones. We have implemented the prototype of $E^2GCO$ on different brands of smartphones and conducted a comprehensive user study to validate its efficacy. The user study demonstrates $E^2GCO$'s superior smartphone control capabilities across various scenarios.
Mineral chemistry and geochemistry as proxy for petrogenetic evaluation of charnockites: evidences from Marandahalli, Salem Block of Southern India
Authors: Amarendhar S. , Priya V. Sai Krishna , Vittal M. , Srin M. 
Published: February 2024

Abstract
The present work highlights the petrogenesis of charnockites from the Marandahalli, Dharmapuri District, Tamil Nadu that are conformably emplaced into an older basement of the Precambrian Peninsular Gneissic Complex (PGC). These charnockites form a part of the southern granulitic terrain in the Salem Block (SB) of Tamil Nadu that is marked by diverse lithology that ranges from ultramafic rocks, syenites, quartz-syenites, carbonatites to granites. The charnockites are medium to coarse grained, in-equigranular, displaying porphyroblastic and granophyric textures, and are composed of felsic minerals like plagioclase feldspars (~ 49–66 vol.%), K-feldspar (~ 1–5 vol.%) and quartz. The mafic minerals are dominated by pyroxene (~ 2–7 vol.%) and biotite (~ 1–12 vol.%), and are marked by the absence of garnet. The accessory minerals include magnetite and apatite. The chemistry of these rocks show a distinctive calc-alkaline signatures marked by high SiO2 (~ 65–68 wt.%), Na2O > K2O, with a marginally high CaO (~ 3–5 wt.%), MgO (~ 2.5-4 wt.%) and FeO (~ 1.5-5 wt.%), that are typical of charnockite rocks and they are surmised to have originated from the amphibolite source material and of magnesian nature. The LREE-rich and HREE-depleted patterns indication low degree of partial melting. V, Rb and Ni trace element of the Marandahalli suggest the role of partial melting in the genesis of these rocks. In summary, from the studies carried out it is envisaged that the Marandahalli charnockites melts were derived from amphibolitic sources that are garnet-free.
On the Bessenrodt-Ono type inequality for a wide class of $A$-partition functions
Authors: Gajdzica Krystian 
Published: February 2024

Abstract
The $A$-partition function $p_A(n)$ enumerates those partitions of $n$ whose parts belong to a fixed (finite or infinite) set $A$ of positive integers. On the other hand, the extended $A$-partition function $p_A\left(\bm{\mu}\right)$ is defined as an multiplicative extension of the $A$-partition function to a function on $A$-partitions. In this paper, we investigate the Bessenrodt-Ono type inequality for a wide class of $A$-partition functions. In particular, we examine the property for both the $m$-ary partition function $b_m(n)$ and the $d$-th power partition function $p_d(n)$. Moreover, we show that $b_m(\bm{\mu})$ ($p_d(\bm{\mu})$) takes its maximum value at an explicitly described set of $m$-ary partitions (power partitions), where $\bm{\mu}$ is an $m$-ary partition (a power partition) of $n$. Additionally, we exhibit analogous results for the Fibonacci partition function and the 'factorial' partition function. It is worth pointing out that an elementary combinatorial reasoning plays a crucial role in our investigation.
A Blockchain-Assisted Lightweight Privacy Preserving Authentication Protocol for Peer-to-Peer Communication in Vehicular Ad-hoc Network
Authors: Payattukalanirappel Sharon Justine , Vamattathil Panchami V , Cheeramthodika Mohammed Ziyad C 
Published: February 2024

Abstract

Vehicular Ad-Hoc Network (VANET), provides considerable real-time traffic information services that enhance safety and traffic effectiveness. However, as most of the VANET systems are centralized in nature prone to single-point failure, vulnerable to attacks and there will be reasonable latency in communication. In this paper, while considering the resource-constrained nature of VANET, a lightweight privacy-preserving authentication scheme for peer-to-peer communication using blockchain (DLPA) is proposed. We have designed and deployed smart contracts using Public blockchain to resist the vehicle impersonation attack, to identify illegal vehicle's identity and thereby non-repudiation will be achieved. Vehicle-to-Vehicle (V2V) authentication and peer-to-peer communication are attained without the involvement of a Trusted Authority (TA) and to eliminate the trusted third party who is responsible for generating the key. Furthermore, DLPA has achieved handover authentication of vehicles so that vehicles need not be re-authenticated when they enter into a new Road Side Unit (RSU) limit. The proposed scheme is implemented in different Ethereum powered test networks using Remix IDE to demonstrate the feasibility and to analyze the performance of the smart contract in terms of transaction cost and execution cost. In addition to that, security proof and analysis are performed to unveil that our proposed scheme preserves the privacy of the communicating parties, semantic security of the session key, and resistance against various known threats and attacks. Finally, the performance analysis of the scheme is done by calculating the communication and computation costs. While analyzing the result, the proposed protocol has a minimal cost when compared with other blockchain-based authentication schemes in VANET.
Optimization of lattice steel structures. A parametric approach based on statically determined structures
Authors: Tarabay Murilo A. K. , Lima Leonardo S. 
Published: February 2024

Abstract
Although several optimization methods have been developed in recent years, their application in real projects is still not widespread due to the complexity of implementation. This paper presents a simplified practical methodology for optimizing trussed steel structures with a focus on the feasibility of the structural solution. The proposed method is parameterized based on statically determined structures with topologies inspired by Michell trusses. In the examples evaluated, the reduction in self-weight reached 24.6% combined with a reduction in displacements of 29,3% in relation to conventional structures.
Body Image and Quality of life undergoing totally robotic versus robotic- assisted distal gastrectomy: A retrospective propensity score matched cohort study
Authors: Ju Hou-qiong , Yuan Yu-li , Yu Hong-xin , Gao Geng-mei , Liu Ya-xiong , Liang Ya-hang , Li Tao , Liu Yang , Liu Dong-ning , Li Tai-yuan 
Published: February 2024

Abstract
Background
With the improvement of anastomotic techniques and the iteration of anastomotic instruments, robotic intracorporeal suturing has become increasingly proficient. The era of fully intracorporeal anastomosis in robotic gastric cancer resection is emerging. This study aims to explore the impact of totally robotic distal gastrectomy (TRDG) and robotic-assisted distal gastrectomy (RADG) on patients' quality of life and survival.
Patients and Methods
This study is a comparative retrospective study of propensity score matching. This study included 306 patients who underwent robotic distal gastrectomy for gastric cancer between June 2016 and December 2022 at our center. Covariates used in the propensity score included sex, age, BMI, ASA score, maximum tumour diameter, degree of histological differentiation, Pathological TNM stage, Pathological T stage, Pathological N stage, and Lauren classification. Outcome measures included operative time, intraoperative bleeding, time to first venting, time to first fluid intake, postoperative hospital stay, total hospitalization cost, total length of abdominal incision, postoperative complications, inflammatory response, body image, quality of life, Disease-Free Survival (DFS), and Overall Survival (OS).
Results
According to the results of the study, compared with the RADG group, the TRDG group had a faster recovery time for gastrointestinal function (P = 0.025), shorter length of abdominal incision (P < 0.001), fewer days in the hospital (P = 0.006) less pain (P < 0.001), less need for additional analgesia (P = 0.013), and a postoperative white blood cell count (P < 0.001) and C-reactive protein content indexes were lower (P<0.001). In addition, the TRDG group had significantly better body imagery and cosmetic scores (P = 0.015), physical function (P = 0.039), role function (P = 0.046), and global function (P = 0.021) than the RARS group. Meanwhile, the TRDG group had milder symptoms of fatigue (P = 0.037) and pain (P < 0.001). The PASQ Total Subscale Score (P < 0.001) and Global Subscale Score (P < 0.001) were significantly lower in the TRDG group than in the RADG group at postoperative 3 months. OS and DFS were not significantly different between the two groups (P = 0.236, P = 0.179).
Conclusion
Totally robotic distal gastrectomy has a smaller incision, faster gastrointestinal recovery time, fewer days of postoperative hospitalization, and lower inflammatory markers than robotic-assisted distal gastrectomy. At the same time, postoperative cosmetic and quality of life outcomes were satisfactory.