bluuebunny/crossref_metadata_2025_split huggingface dataset:
Haemodialysis patients and end‐of‐life decisions: a theory of personal preservation
Authors: Calvin Amy Olivier 
Published: May 2004

Background.  Lack of knowledge about the end‐of‐life treatment preferences of patients undergoing haemodialysis is problematic in the acute care setting as, often, patients are unable to communicate their treatment wishes effectively and have not previously documented their desires in the form of advance directives. Existing theoretical models offer an incomplete explanation of end‐of‐life treatment decisions in haemodialysis patients.Aim.  This paper reports a study exploring decisions about end‐of‐life treatment (e.g. cardiopulmonary resuscitation, mechanical ventilation) in people with kidney failure undergoing haemodialysis.Methods.  Grounded theory was used. Theoretical sampling led to selection of 20 haemodialysis patients (11 men and nine women with a mean age of 56) who attended three dialysis outpatient centres in central Texas. They were interviewed about end‐of‐life treatment plans and the use of advance directives (i.e. living wills and durable powers of attorney for health care). Interviews, transcripts and field notes from the first 12 patients were analysed by making constant comparisons. The remaining eight interviews were used for validation purposes. Data collection and analysis spanned the years 1997–2000.Findings.  When prompted to think about and discuss end‐of‐life treatments, haemodialysis patients chose to focus on living rather than dying. A substantive theory of ‘personal preservation’ was developed. This consists of three phases: knowing the odds for survival, defining individuality (beating the odds, discovering meaning, being optimistic and having faith in a higher force) and personal preservation (being responsible and taking chances).Conclusions.  The theory of personal preservation furthers understanding of illness behaviour and the process by which patients make decisions about end‐of‐life treatments. It can be used to sensitize health care professionals to patients’ desires and to enhance patient‐professional communication.
The pathology of phosphorus deficiency in fish – a review
Authors: Sugiura S H , Hardy R W , Roberts R J 
Published: May 2004

AbstractPhosphorus (P) is an essential component of fish diets. Its deficiency affects not only hard tissues, where it is responsible for rickets, leading to skeletal malformation, but also influences various aspects of intermediary metabolism, and thus growth and feed conversion. Therefore, optimizing the dietary inclusion level is critical at all times. As the aquaculture industry has expanded, so the effects of P in farm effluents, derived from metabolic and uneaten food sources, have also become recognized. Diets are increasingly formulated on a basis that will not only provide adequate P for fish needs, but also endeavour to ensure minimal acceptable P levels in effluents at the same time. Many variables influence P requirements and P availability in fish diets, so it is inadvisable to feed diets formulated to an assumed minimum dietary requirement level, irrespective of the advantages that such a formulation may provide to environmental impact.
Infection experiments with Aphanomyces invadans in four species of estuarine fish
Authors: Johnson R A , Zabrecky J , Kiryu Y , Shields J D 
Published: May 2004

AbstractAlong the eastern seaboard of the US, Atlantic menhaden, Brevoortia tyrannus, develop characteristic ulcerative lesions, a condition termed ulcerative mycosis. These lesions are identical to those seen across Asia in fish affected by epizootic ulcerative syndrome, a condition caused by the fungus‐like oomycete Aphanomyces invadans. Young‐of‐the‐year menhaden inhabiting estuarine environments are the primary species affected in the USA and little is known about the factors involved in the initiation of the lesions, or why menhaden are predominantly infected. Atlantic menhaden, hogchoker, Trinectus maculatus, striped killifish, Fundulus majalis, and mummichog, Fundulus heteroclitus, were inoculated with A. invadans (80 zoospores per fish) to explore species differences in infection and lesion development. All four species developed lesions. Killifish developed frank lesions similar to those observed in menhaden but the gross lesions occurred later, approximately 5–10 days after those on menhaden. Hogchoker and mummichog did not develop gross skin ulcers; rather, their lesions appeared as reddened areas under the epidermis. Mummichogs also showed evidence of significant healing with a well‐developed granuloma and significant myocyte regeneration. These experiments show that species barriers as well as ecological barriers can explain some of the factors involved in the development of lesions in, and specificity of the water mould for, menhaden.
Diet, anthropometric measures and prostate cancer risk: a review of prospective cohort and intervention studies
Authors: Dagnelie P.C. , Schuurman A.G. , Goldbohm R.A. , Van Den Brandt P.A. 
Published: May 2004

ABSTRACTWe reviewed 37 prospective cohort and four intervention studies on potential dietary risk factors for prostate cancer, published between 1966 and September 2003. Some studies were limited by small size, crude measurement of dietary exposure and limited control for confounders. Intervention and prospective cohort studies support a protective role against prostate cancer for selenium, and possibly for vitamin E, pulses and tomatoes/lycopene. Overall consumption of meat, eggs, vegetables, fruit, coffee, tea, carotenoids and vitamins A, C and D was not consistently related to prostate cancer risk. Intervention studies also indicate that supplementation with β‐carotene does not lower prostate cancer risk, except possibly in men with low β‐carotene status at baseline. For specific types of meat, alcoholic drinks, dairy products, fat and anthropometric measures, most cohort studies suggest either an increased risk or no relation with prostate cancer. For calcium, two cohort studies suggest an increased risk at very high calcium intakes (>2000 mg/day). In conclusion, prospective studies are consistent with a protective role for selenium, and possibly vitamin E, pulses and tomatoes/lycopene, in the aetiology of prostate cancer. Studies are inconclusive on the role of meat, dairy products, fat, vegetables, fruits, alcohol and anthropometric measures, whereas a very high calcium intake appears to be positively associated with prostate cancer risk.
Art as an investment: risk, return and portfolio diversification in major painting markets
Authors: Worthington Andrew C. , Higgs Helen 
Published: May 2004

AbstractThe present paper examines risk, return and the prospects for portfolio diversification among major painting and financial markets over the period 1976–2001. The art markets examined are Contemporary Masters, French Impressionists, Modern European, 19th Century European, Old Masters, Surrealists, 20th Century English and Modern US paintings. The financial markets comprise US Treasury bills, corporate and government bonds and small and large company stocks. In common with the published literature in this area, the present study finds that the returns on paintings are much lower and the risks much higher than conventional investment markets. Moreover, while low correlations of returns suggest that opportunities for portfolio diversification in art works alone and in conjunction with equity markets exist, the construction of Markowitz mean‐variance efficient portfolios indicates that no diversification gains are provided by art in financial asset portfolios. However, diversification benefits in portfolios comprised solely of art works are possible, with Contemporary Masters, 19th Century European, Old Masters and 20th Century English paintings dominating the efficient frontier during the period in question.
A novel visual analogue scale (VAS) device: an instrument based on the VAS designed to quantify the subjective visual experience
Authors: Pointer Jonathan S. 
Published: May 2004

AbstractPurpose : To evaluate a novel device intended to facilitate the direct quantification of the subjective visual experience. The design principle is based on that of the visual analogue scale (VAS) technique but obviates the need for subsequent measurement unlike the administration of the conventional paper VAS.Methods : The visual experience of 134 normally sighted 17–40‐year‐olds was quantified using (in randomised sequence) a paper VAS and the novel VAS device. A notional 100‐point scale was utilised in either case, and the extreme descriptive anchors for both instruments were ‘dreadful’ and ‘perfect’.Results : The degree of clinical agreement between the two alternative VAS techniques was very high. A small bias (mean = +0.7 VAS units: 95% confidence interval 0.3–1.2 units) towards the paper VAS was evident in these data, an outcome of no clinical significance or impediment as regards the substitution of the novel device for the conventional paper‐based approach.Conclusions : The moving of a bead along a wire is shown to be a clinically and statistically reliable alternative procedure to the pen‐marking of a conventional paper VAS for the evaluation of the recent subjective visual experience, provided that the same minimum/maximum descriptive anchors are used for either instrument. The instant quantification of the VAS score afforded by the novel technique introduced here broadens the potential clinical application of this technique.
UTP and diadenosine tetraphosphate accelerate wound healing in the rabbit cornea
Authors: Pintor Jesús , Bautista Alfredo , Carracedo Gonzalo , Peral Assumpta 
Published: May 2004

AbstractNucleotides are naturally occurring substances present in tear film that can stimulate tear secretion in animals and humans. We investigated whether certain nucleotides can affect the rate of wound healing in the cornea of white rabbits. In the absence of any added compound, the rate of healing was 72.4 ± 2.2 μm h−1. Of all the tested nucleotides, UTP and Ap4A were the most active ones, maximally increasing the rate of healing to 121.6 ± 3.7 and 93.7 ± 3.2 μm h−1, respectively. Responses to UTP were dose dependent. UTP had a pD2 value of 8.9 ± 0.1 (EC50: 1.25 nM). P2 purinoceptor antagonists such as suramin and reactive blue‐2, inhibited the effect of UTP indicating the involvement of P2Y receptors. Mitogen‐activated protein kinase (MAPK) cascade inhibitors also abolished the effects of UTP, suggesting that P2Y receptors are coupled to the MAPK cascade, and that this is involved in controlling the rate of epithelial cell migration.
Correctable visual impairment in older people: a major unmet need
Authors: Evans Bruce J. W. , Rowlands Gillian 
Published: May 2004

AbstractThis review seeks to determine the prevalence of correctable visual impairment (VI) in older people in the UK, to discover what proportion of these cases are undetected, to suggest reasons for the poor detection and to make recommendations for improving the detection. To establish the context of these issues, the review will also touch on the general prevalence and causes of VI in older people in developed countries and on the impact of VI in older people. Typically, studies suggest that VI affects about 10% of people aged 65–75, and 20% of those aged 75 or older. There is a strong relationship between impaired vision in older people and both reduced quality of life and increased risk of accidents, particularly falls. The literature suggests that those with low vision are about two times more likely to have falls than fully sighted people, and the annual UK cost of treating falls directly attributable to VI is £128 million. The literature on the prevalence of undetected reduced vision in older people reveals that between 20 and 50% of older people have undetected reduced vision. The majority of these people have correctable visual problems (refractive errors or cataract). It is particularly startling that, in ‘developed countries’, between 7 and 34% of older people have VI that could simply be cured by appropriate spectacles. The reasons why so many cases of treatable VI remain untreated are discussed, and suggestions are made for improving the detection of these cases. We conclude that there should be better publicity encouraging older people to attend for regular optometric eye examinations. A complementary approach is annual visual screening of the elderly, possibly as part of GPs annual health check on people aged 75 years and older. Recommendations are made for evaluating new approaches to screening and for improving the management of cases detected by screening.
Interactions between serpentinite devolatilization, metasomatism and strike‐slip strain localization during deep‐crustal shearing in the Eastern Alps
Authors: Barnes J. D. , Selverstone J. , Sharp Z. D. 
Published: May 2004

AbstractThe Greiner shear zone in the Tauern Window, Eastern Alps, changes from a zone of distributed (dominantly sinistral) shear in supracrustal rocks to a series of narrow, gully forming dextral splays where it enters basement gneisses. Within these splays, granodiorite is transformed into quartz‐poor biotite and/or chlorite schists, reflecting hydration, removal of Si, Ca and Na, and concentration of Fe, Mg and Al. Stable isotope analyses show a prominent increase in δD and a decrease in δ18O from granodiorite into the shear zones. These changes indicate significant channelized flow of an externally derived, low‐δ18O, high‐δD fluid through the shear zones. The shear zone schists are chemically similar to blackwall zones developed around serpentinite bodies elsewhere in the Greiner zone and the stable isotope data support alteration via serpentinite‐derived fluid. Monazite in schist from one shear zone yields spot dates of 29–20 Ma, indicating that the fluid influx and switch from sinistral to dextral shear occurred at or shortly after the thermal peak of the Alpine orogeny (c. 30 Ma). We suggest that Alpine metamorphism of serpentinites released large amounts of high‐δD, low‐δ18O, Si‐undersaturated, Fe + Mg‐saturated fluids that became channelized along prior zones of weakness in the granodiorite. Infiltration of this fluid facilitated growth of chlorite and biotite, which in turn localized later dextral strain in the narrow splays via cleavage‐parallel slip. This dextral strain event can be linked to other structures that accommodated tectonic escape of major crustal blocks during dextral transpression in the Eastern Alps. This study shows that serpentinite devolatilization can play an important role in modifying both the chemistry and rheology of surrounding rocks during orogenesis.
Metamorphic evolution of kyanite–staurolite‐bearing epidote–amphibolite from the Early Palaeozoic Oeyama belt, SW Japan
Authors: Tsujimori T. , Liou J. G. 
Published: May 2004

AbstractEarly Palaeozoic kyanite–staurolite‐bearing epidote–amphibolites including foliated epidote–amphibolite (FEA), and nonfoliated leucocratic or melanocratic metagabbros (LMG, MMG), occur in the Fuko Pass metacumulate unit (FPM) of the Oeyama belt, SW Japan. Microtextural relationships and mineral chemistry define three metamorphic stages: relict granulite facies metamorphism (M1), high‐P (HP) epidote–amphibolite facies metamorphism (M2), and retrogression (M3). M1 is preserved as relict Al‐rich diopside (up to 8.5 wt.% Al2O3) and pseudomorphs after spinel and plagioclase in the MMG, suggesting a medium‐P granulite facies condition (0.8–1.3 GPa at > 850 °C). An unusually low‐variance M2 assemblage, Hbl + Czo + Ky ± St + Pg + Rt ± Ab ± Crn, occurs in the matrix of all rock types. The presence of relict plagioclase inclusions in M2 kyanite associated with clinozoisite indicates a hydration reaction to form the kyanite‐bearing M2 assemblage during cooling. The corundum‐bearing phase equilibria constrain a qualitative metamorphic P–T condition of 1.1–1.9 GPa at 550–800 °C for M2. The M2 minerals were locally replaced by M3 margarite, paragonite, plagioclase and/or chlorite. The breakdown of M2 kyanite to produce the M3 assemblage at < 0.5 GPa and 450–500 °C suggests a greenschist facies overprint during decompression. The P–T evolution of the FPM may represent subduction of an oceanic plateau with a granulite facies lower crust and subsequent exhumation in a Pacific‐type orogen.
Are Momentum Profits Robust to Trading Costs?
Authors: Korajczyk Robert A. , Sadka Ronnie 
Published: May 2004

ABSTRACTWe test whether momentum strategies remain profitable after considering market frictions induced by trading. Intraday data are used to estimate alternative measures of proportional and non‐proportional (price impact) trading costs. The price impact models imply that abnormal returns to portfolio strategies decline with portfolio size. We calculate break‐even fund sizes that lead to zero abnormal returns. In addition to equal‐ and value‐weighted momentum strategies, we derive a liquidity‐weighted strategy designed to reduce the cost of trades. Equal‐weighted strategies perform the best before trading costs and the worst after trading costs. Liquidity‐weighted and hybrid liquidity/value‐weighted strategies have the largest break‐even fund sizes: $5 billion or more (relative to December 1999 market capitalization) may be invested in these momentum strategies before the apparent profit opportunities vanish.
Executive Option Repricing, Incentives, and Retention
Authors: Chen Mark A. 
Published: May 2004

ABSTRACTWhile many firms grant executive stock options that can be repriced, other firms systematically restrict or prohibit repricing. This article investigates the determinants of firms' repricing policies and the consequences of such policies for executive turnover and retention. Firms that have better internal governance, that use more powerful stock‐based incentives, or that face less shareholder scrutiny are more likely to maintain repricing flexibility. Firms that restrict repricing are more vulnerable to voluntary executive turnover following stock price declines. When share price declines are severe, restricting firms appear to award unusually large numbers of new options.
Do Stock Prices and Volatility Jump? Reconciling Evidence from Spot and Option Prices
Authors: Eraker Bjørn 
Published: May 2004

ABSTRACTThis paper examines the empirical performance of jump diffusion models of stock price dynamics from joint options and stock markets data. The paper introduces a model with discontinuous correlated jumps in stock prices and stock price volatility, and with state‐dependent arrival intensity. We discuss how to perform likelihood‐based inference based upon joint options/returns data and present estimates of risk premiums for jump and volatility risks. The paper finds that while complex jump specifications add little explanatory power in fitting options data, these models fare better in fitting options and returns data simultaneously.
Specification Analysis of Option Pricing Models Based on Time‐Changed Lévy Processes
Authors: Huang Jing‐zhi , Wu Liuren 
Published: May 2004

ABSTRACTWe analyze the specifications of option pricing models based on time‐changed Lévy processes. We classify option pricing models based on the structure of the jump component in the underlying return process, the source of stochastic volatility, and the specification of the volatility process itself. Our estimation of a variety of model specifications indicates that to better capture the behavior of the S&P 500 index options, we need to incorporate a high frequency jump component in the return process and generate stochastic volatilities from two different sources, the jump component and the diffusion component.
A Child's Experience of Parental Depression: Encouraging Relational Resilience in Families with Affective Illness*
Authors: Focht‐Birkerts Lynn , Beardslee William R. 
Published: May 2004

In this article, we describe an approach that parents with affective illness can use to foster the emotional resilience of their children. Building on current research that emphasizes the need to formulate concepts of risk and resilience in terms of family or relational processes, we propose that affectively ill parents can promote resilience in their children by helping them express the affect they experience as a result of parental illness‐related behavior. Risk and resilience are conceptualized in terms of a family's ability to process emotion or affect: a family's need to constrict affect is a risk factor, while the family's ability to elaborate affect encourages relational resilience. An object relations model is used to discuss the ways in which encouraging this elaboration of affect, especially negative affect, contributes to resilience in children. We describe ways in which a preventive intervention helps to increase parents' emotional responsiveness to their children. Using extensive narrative data from followup interviews with families and children, constriction and expansion of emotion in children concerning affectively ill parents are documented, by multiple interviewers, over a span of more than 5 years.Where danger threatens, there also grows the saving power.—J.C.F. Hölderlin1Patmos
Chronic Illness: Trauma, Language, and Writing: Breaking the Silence*
Authors: Penn Peggy 
Published: May 2004

In our work with families that struggle with a chronic illness, we have relied on three ideas. First, we regard illness as a relationally traumatizing experience, not just for the person with the illness, but for other members of the family as well. We use the phrase “relational trauma” because of its effects on members of a wider system who also show signs of physical stress, isolation, and helplessness (Sheinberg & Fraenkel, 2000). Our second concern is how the conversation that leads to new stories is expanded through the development of voice and the use of writing. Looking at language, we are particularly attentive to the social prevalence of negative metaphors that surround and engulf the ill person and her family: dependence, poor genes, repressed personalities, weak constitutions, et cetera (Sontag, 1984). These negative metaphors, or outside voices, join with the inner voices of the ill person and result in a silence that disconnects people at a time when connections must be relied on and above question. Our third emphasis is on the use of writing as the means to create new voices, metaphors, and multiple descriptions that can reinvigorate the conversations silenced by the illness. Once the family's voices are reconstituted through writing, the emotions that have been displaced by the illness are restored to their conversation. I have included new research from JAMA detailing the treatment of patients with chronic illness through their use of writing.
I was 43 years old, a practicing, licensed psychologist for over 25 years, and happily married to the man with whom I was raising a 14‐year‐old son and an 11‐year‐old daughter. I had just finished one year of treatment for cancer, a treatment the noted surgeon, Dr. Susan Love [citation omitted] refers to as “slash, cut, and burn.” My life was bleak and lonely because I lived in silence: certain that no one could bear to hear the feelings and thoughts I had following my year of treatment; unwilling to find out if I was right; certain that I needed to protect people from my experiences; and failing in those few times that I tried to put into words the chaos of my emotions and the terror that lived in my flesh.—Kaethe Weingarten (2000, p. 390)