bluuebunny/crossref_metadata_2025_split huggingface dataset:
Project coordination success factors in European Union-funded research, development and innovation projects under the Horizon 2020 and Horizon Europe programmes
Authors: Tenhunen-Lunkka Anna , Honkanen Riitta 
Published: January 2024

AbstractSuccess factors for managing European Union-funded research, development and innovation projects is rather uncharted territory and scarce publications exist, even though considering that the H2020 funding was nearly €80 billion, and Horizon Europe is €95,5 billion. Managing these types of projects has been referred to as ‘managing the unmanageable’, which indicates importance of our study. The aim of this study was to gather input via survey from both project coordinators and partners by assessing factors in five categories of good practices, skills, characteristics and tools of project management, and coordination for successful project implementation. A total of 118 persons replied to the survey who have experience from Horizon 2020 or Horizon Europe funded project(s). Over 80 factors were assessed and rated by the participants. Via standard statistical analysis, a top three lists were created for the different categories from both project partners and coordinators perspectives. A combination of 15 top success factors was formed. Furthermore, to emphasise the practicality of the results, an overarching framework was formed where we propose three prioritised key success factors that research, development, and innovation project management of should focus on. The three key success factors are communication, trust, and collaboration. Communication and trust are further traced down to the coordinator and consortium levels. Active communication and good listening skills are key. Mutual trust is built through high motivation, competence, and active approach to dedicated project activities and roles. Efficient collaboration is reached by nourishing inclusivity and culture, creating a productive environment, and good administrative practices.
Development and validation of School Resilience Questionnaire (SRQ) in Iranian adolescents
Authors: Afzali Leila , Hosseinian Simin 
Published: January 2024

Abstract
Background
School resilience, encompassing factors like teacher involvement and school supportiveness, is crucial for positive educational outcomes in adolescents. However, few validated scales measure school resilience. This study aimed to develop and validate the School Resilience Questionnaire (SRQ) for Iranian adolescents.

Methods
The study used a cross-sectional design. The SRQ was developed through expert reviews, interviews with students, and evaluation of existing resilience measures. After expert feedback, the final 55-item questionnaire was used. Participants were high school adolescents from Tehran, Iran (2021–2022). A multi-stage cluster random sampling approach was used. Exploratory Factor Analysis (EFA) involved 200 students, and Confirmatory Factor Analysis (CFA) included 310 students to validate the factor structure. Convergent validity was assessed by examining correlations with academic support, while divergent validity was evaluated using academic burnout measures. Construct validity and reliability were also assessed.

Results
EFA revealed six consistent factors across the sample. CFA confirmed significant and acceptable factor loadings for all SRQ items. Fit indices were RMSEA = 0.076; SRMR = 0.070, CFI = 0.94, NFI = 0.93, IFI = 0.94, RFI = 0.93. Convergent validity showed positive correlations between SRQ subscales and academic support. Divergent validity showed negative correlations between SRQ subscales and academic burnout (p < 0.05).

Conclusion
The study successfully developed and validated the 55-item SRQ for Iranian adolescents. The questionnaire demonstrates satisfactory psychometric properties, making it a valuable tool for research and evaluation purposes in this context.
Flexibility and inflexibility in an Iranian sample: psychometric properties of MPFI based on the Hexaflex model
Authors: Moosivand Mahboobeh , Kulemarzi Mohammad Javad Bagian , Shirazi Maryam Sayad , Zaremohzzabieh Zeinab 
Published: January 2024

Abstract
Objectives
Acceptance and Commitment Therapy (ACT) emphasizes the importance of psychological flexibility in promoting emotional, psychological, and social well-being, while also acknowledging rigidity as a precursor to psychological disorders. Analyzing the psychometric qualities based on the multidimensional Hexaflex model is critical for determining the efficiency of therapeutic interventions. Thus, the purpose of this study is to investigate the psychometric features of the Multidimensional Psychological Flexibility Inventory (MPFI) within the context of the Hexaflex model in a group of Iranian university students.

Methods
Exploratory and confirmatory factor analyses were used in this study to evaluate the psychometric features of the flexibility/inflexibility scale (MPFI) in a sample of Iranian university students.

Findings
In the exploratory factor analysis involving a sample of 300 students, six factors were identified for flexibility and six for inflexibility (56.3% males and 43.7% females). In the confirmatory factor analysis with a sample of 388 participants, the results validated 60 items across a total of six flexibility and inflexibility factors. This outcome can serve as a robust estimate for flexibility, inflexibility, the second-order model, and the final model. Cronbach’s alpha values for various components, including acceptance, present-moment awareness (or contact with the present moment), self as context, cognitive defusing, values, committed action, total flexibility, experiential avoidance, lack of present-moment awareness, self as content, fusion, lack of contact with values, inaction, and total inflexibility, were reported as follows: 0.818, 0.869, 0.862, 0.904, 0.935, 0.935, 0.942, 0.895, 0.839, 0.883, 0.904, 0.912, 0.941, and 0.941, respectively.

Conclusions
The Farsi version of the MPFI for university students has great psychometric qualities, making it a reliable assessment instrument for the ACT.
English Cocker Spaniels under primary veterinary care in the UK: disorder predispositions and protections
Authors: Engdahl Karolina S. , Brodbelt Dave C. , Cameron Carla , Church David B. , O’Neill Dan G. 
Published: January 2024

Abstract
Background
The English Cocker Spaniel (ECS) is one of the most popular dog breeds in the UK but information on disorder predisposition and protection is limited. Using anonymised veterinary clinical data from the VetCompass™ Programme, this study aimed to compare disorder predisposition and protection between the ECS and the remaining dogs under primary veterinary care in the UK during 2016. Electronic patient records for random samples of ECS and non-ECS were reviewed. The most common disorders diagnosed during 2016 were extracted and compared using multivariable logistic regression, controlling for confounders.

Results
The analysis included random samples of 2510/10,313 (24.3%) ECS and 7813/326,552 (2.39%) non-ECS. After accounting for confounding by age, sex, bodyweight within breed-sex, insurance status and veterinary practice group, the ECS had increased odds of 21/43 (48.85%) disorders at fine-level precision, with highest odds for aural discharge (odds ratio (OR) 14.66, 95% confidence interval (CI): 7.73–30.90, P <  0.001) and keratoconjunctivitis sicca (OR 7.64, 95% CI: 4.33﻿–14.14, P <  0.001) and lowest odds for atopic dermatitis (OR 0.14, 95% CI: 0.05–0.31, P <  0.001) and allergy (OR 0.14, 95% CI: 0.06–0.28, P <  0.001).

Conclusions
This study provides evidence for strong predisposition to aural and ocular disorders and protection from hypersensitivity disorders in the ECS. These results can aid dog owners, breeders, and veterinarians to better monitor health in ECS, and promote earlier diagnosis with improved prognosis. Further, the results can help breeding organisations establish key priorities the health-based reforms of the ECS.
Intervention mechanism of marine-based chito-oligosaccharide on acute liver injury induced by AFB1 in rats
Authors: Chen Lin , Yan Jiahui , Shi Huijun , Zhang Zhaohuan , Zhao YueLiang , Zhao Yong , Wang Yuan , Ou Jie 
Published: January 2024

AbstractAflatoxin B1 (AFB1) is extremely hepatotoxic, a causative agent of liver cancer, and can cause symptoms of acute or chronic liver damage. Chito-oligosaccharides (COS), obtained from the degradation of chitosan derived from shrimp and crab shells, is a natural antioxidant substance and its antitumor properties have been widely studied, but less research has been done on the prevention of AFB1-induced acute liver injury. In this study, rats were acutely exposed to 1 mg/kg BW AFB1 and simultaneously gavaged with different doses of COS for 8 days. The results showed that COS attenuated the hepatic histopathological changes and reduced serum biochemical indices (ALT, AST, ALP, and TBIL) in rats. It significantly inhibited MDA content and promoted SOD and GSH-Px activity production. Moreover, it also improved hepatocyte apoptosis. Furthermore, AFB1-vs-HCOS differential genes were enriched with 622 GO entries, and 380 were Biological Processes, 170 were Molecular Functions, 72 were Cellular Components. Differentially expressed genes (DEGs) analyzed by KEGG enrichment were more enriched in pathways, such as metabolism, PPAR signaling pathway, and peroxisome. Q-PCR technique verified that Lama5, Egr1, Cyp2b1, and Gadd45g in DEGs were associated with oxidative stress damage and apoptosis. In conclusion, COS intervention reduces the effect of AFB1 on hepatic genes and thus reduces the changes in hepatic gene function.
Graphical abstract
Effect of Hashimoto’s thyroiditis on the dual-energy CT quantitative parameters and performance in diagnosing metastatic cervical lymph nodes in patients with papillary thyroid cancer
Authors: Geng Di , Zhou Yan , Shang Ting , Su Guo-Yi , Lin Shu-shen , Si Yan , Wu Fei-Yun , Xu Xiao-Quan 
Published: January 2024

Abstract
Background
To evaluate the effect of Hashimoto’s thyroiditis (HT) on dual-energy computed tomography (DECT) quantitative parameters of cervical lymph nodes (LNs) in patients with papillary thyroid cancer (PTC), and its effect on the diagnostic performance and threshold of DECT in preoperatively identifying metastatic cervical LNs.

Methods
A total of 479 LNs from 233 PTC patients were classified into four groups: HT+/LN+, HT+/LN−, HT−/LN + and HT−/LN − group. DECT quantitative parameters including iodine concentration (IC), normalized IC (NIC), effective atomic number (Zeff), and slope of the spectral Hounsfield unit curve (λHU) in the arterial phase (AP) and venous phase were compared. Receiver operating characteristic curve analyses were performed to evaluate DECT parameters’ diagnostic performance in differentiating metastatic from nonmetastatic LNs in the HT − and HT + groups.

Results
The HT+/LN + group exhibited lower values of DECT parameters than the HT−/LN + group (all p < 0.05). Conversely, the HT+/LN − group exhibited higher values of DECT parameters than the HT−/LN − group (all p < 0.05). In the HT + group, if an AP-IC of 1.850 mg/mL was used as the threshold value, then the optimal diagnostic performance (area under the curve, 0.757; sensitivity, 69.4%; specificity, 71.0%) could be obtained. The optimal threshold value of AP-IC in the HT − group was 2.050 mg/mL. In contrast, in the HT − group, AP-NIC demonstrated the highest area under the curve of 0.988, when an optimal threshold of 0.243 was used. The optimal threshold value of AP-NIC was 0.188 in the HT + group.

Conclusions
HT affected DECT quantitative parameters of LNs and subsequent the diagnostic thresholds. When using DECT to diagnose metastatic LNs in patients with PTC, whether HT is coexistent should be clarified considering the different diagnostic thresholds.
Diagnostic and prognostic significance of tissue lncRNA HOTAIR and hexokinase 2 mRNA expression in patients with pancreatic ductal adenocarcinoma
Authors: Salah Ghada , Obada Manar , Sweed Dina , Salama Ibrahim Abdelkader , Khalil Ashraf , Abdelsattar Shimaa 
Published: January 2024

Abstract
Background
Pancreatic adenocarcinoma, recognized for its aggressive behavior and frequent late-stage diagnosis, imposes significant challenges in early detection and prognosis. This study aimed to evaluate the diagnostic and prognostic potential by measuring the expression levels of long non-coding RNA HOTAIR and the glycolytic enzyme hexokinase 2 (HK2) mRNA in both tumorous and adjacent non-tumorous pancreatic tissue samples (n = 25 each) using RT-qPCR. Results
Both lncRNA HOTAIR and HK2 expression levels significantly increased in tumorous pancreatic tissues compared to non-tumorous tissue (P = 0.001). However, their levels in stage T2 and T3 showed no statistically significant difference (P = 0.01). lncRNA HOTAIR and HK2 expression levels positively correlated with each other (P = 0.001; r = 0.95); however, no significant associations were found with serum tumor markers CA19-9 and CEA (P = 0.01; r = 005; p = 0.1, r = 0.2). ROC analysis demonstrated the significant abilities of both lncRNA HOTAIR and HK2 expression levels to discriminate between tumorous and non-tumorous pancreatic tissues (AUC = 0.92 and 0.84, respectively) with 96% and 88% sensitivity, and 72% and 40% specificity, respectively, at optimal cut-off values of 1.12 and 0.84 relative expression units. Patients with elevated lncRNA HOTAIR and HK2 expression had shorter median survival (8 and 7 months, respectively), increasing the risk of adverse outcomes or recurrence 4–4.8 times (HR = 4.08, p = 0.07; HR = 4.8, p = 0.01), thus emphasizing their prognostic potential in pancreatic cancer.

Conclusion
lncRNA HOTAIR and HK2 expression levels exhibit diagnostic potential in pancreatic tumors. Elevated levels of both markers correlate strongly with adverse outcomes, underscoring their prognostic value.
The ℓ1−2-norm-regularized basis pursuit seismic inversion based on the exact Zoeppritz equation
Authors: Huang Guangtan , Wei Shuying , Gei Davide , Wang Tongtao 
Published: January 2024

Sparsity constraints have been widely adopted in the regularization of ill-posed problems to obtain subsurface properties with sparseness features. However, the target parameters are generally not sparsely distributed, and sparsity constraints lead to results that are missing information. Smooth constraints (e.g., [Formula: see text] norm) lead to the insufficient resolution of the inversion results. To overcome this issue, an effective solution is to convert the target parameters to a sparse representation, which can then be solved with sparsity constraints. For the estimation of elastic parameters, a high-resolution and reliable seismic basis pursuit inversion is developed based on the exact Zoeppritz equation. Furthermore, the [Formula: see text] norm is developed as a constraint, wherein a regularized function is minimized with the alternating direction method of the multipliers algorithm. Numerical examples and real data applications demonstrate that our method can not only improve the accuracy of the inversion results, especially the S-wave velocity and density information but also increase the resolution of the inversion results. Furthermore, the [Formula: see text]-norm constraint has better noise suppression demonstrating great potential in practical applications.
Tumor-Informed Circulating Tumor DNA for Minimal Residual Disease Detection in the Management of Colorectal Cancer
Authors: Emiloju Oluwadunni E. , Storandt Michael , Zemla Tyler , Tran Nguyen , Jethwa Krishan , Mahipal Amit , Mitchell Jessica , Thiels Cornelius , Mathis Kellie , McWilliams Robert , Hubbard Joleen , Sinicrope Frank , Shi Qian , Jin Zhaohui 
Published: January 2024

PURPOSE Recurrence after curative-intent treatment occurs in 20%-50% of patients with stage II-IV colorectal cancer (CRC), underscoring the need for early detection of minimal residual disease (MRD) using circulating tumor DNA (ctDNA). Here, we examined the pattern of use of a tumor-informed ctDNA assay in CRC MRD monitoring in routine clinical practice at Mayo Clinic, Rochester. METHODS We conducted a retrospective analysis of health records of patients with CRC who had at least one tumor-informed ctDNA assay from May 2019 through July 1, 2022. Recurrence was defined as radiographic evidence of disease. Descriptive characteristics of the cohort, ctDNA results, and subsequent interventions were recorded. RESULTS Of the 120 patients included, the median age at diagnosis was 67 years, 46% were female, and 94% were White. At diagnosis, 10 patients had stage I, 23 stage II, 60 stage III, and 25 stage IV disease. Of 476 ctDNA assays performed, 70% were performed in patients who had recurrent disease most commonly to monitor the effectiveness of therapeutic interventions and 16% resulted in a change in clinical decision making. There were 110 recurrences identified in 62 patients, as some patients experienced more than one recurrence over time. Compared with serum carcinoembryonic antigen levels, ctDNA results correlated better with radiologic imaging. CONCLUSION Routine ctDNA monitoring for MRD detection has been adopted in clinical practice; however, 84% of ctDNA assays performed did not result in a change in clinical management. This suggests the need for further clinical research data to guide routine clinical use of ctDNA MRD testing in CRC.
Sunny-Day Flooding and Mortality Risk in Coastal Florida
Authors: Mueller Valerie , Hauer Mathew , Sheriff Glenn 
Published: January 2024

Abstract
Sea-level rise is likely to worsen the impacts of hurricanes, storm surges, and tidal flooding on coastal access to basic services. We investigate the historical impact of tidal flooding on mortality rates of the elderly population in coastal Florida using administrative records of individual deaths, demographics, and residential location combined with tidal gauge and high-resolution elevation data. We incorporate data capturing storm and precipitation events into our empirical model to distinguish between disruptions from routine sunny-day flooding and less predictable tropical storm–induced flooding. We find that a 1-standard-deviation (20-millimeter) increase in tidal flooding depth increases mortality rates by 0.46% to 0.60% among those aged 65 or older. Our estimates suggest that future sea-level rises may contribute to an additional 130 elderly deaths per year in Florida relative to 2019, all else being equal. The enhanced risk is concentrated among residents living more than nine minutes away from the nearest hospital. Results suggest that tidal flooding may augment elderly mortality risk by delaying urgent medical care.
Prevalence of Drug Use in Ultraendurance Athletes
Authors: ROBACH PAUL , TREBES GILLES , BUISSON CORINNE , MECHIN NATHALIE , MAZZARINO MONICA , GARRIBBA FLAMINIA , ROUSTIT MATTHIEU , QUESADA JEAN-LOUIS , LEFÈVRE BRICE , GIARDINI GUIDO , DE SEIGNEUX SOPHIE , BOTRÉ FRANCESCO , BOUZAT PIERRE 
Published: January 2024

ABSTRACT

Purpose
In competitive sport, classic methods of measuring drug prevalence, such as doping controls or questionnaires, are challenging. Here we describe a novel urine sampling method to measure drug use in athletes. We hypothesize that the prevalence of drug use in ultramarathon runners is measured more accurately with our sampling method than randomized-response questionnaires.

Methods
Urine samples and associated demographic data were collected from male participants using blind, automated urinals at the start of ultramarathon races. Various nonprohibited and prohibited substances were subsequently screened. Concomitantly, 2931 male and female runners participating in the same ultramarathons completed an anonymized, randomized-response questionnaire regarding drug use.

Results
Among 412 individual urine samples, 205 (49.8%) contained at least one substance, and 16.3% of the samples contained one or more prohibited substances. Substances detected in urine included nonsteroid anti-inflammatory drugs (NSAID) (22.1%), acetaminophen (15.5%), opioids (6.6%), diuretics (4.9%), hypnotics (4.4%), glucocorticoids (2.7%), beta-2 agonists (2.2%), cannabinoids (1.9%), and stimulants (1.2%). None of the samples contained erythropoietin-receptor agonists or suspicious testosterone. Drug use was not associated with the participants’ characteristics or ranking. Respondents to the questionnaire reported using acetaminophen (13.6%) and NSAID (12.9%); however, no prohibited substances were declared.

Conclusions
There was a high prevalence of drug use among male ultramarathon runners, in particular, NSAID and painkillers; however, performance-enhancing drugs were marginally used. Blind urine sampling highlighted prohibited drug use not declared in questionnaires, and it is useful to assess the prevalence of drug use and/or doping in competitive athletes.
Simultaneous type III congenital esophageal atresia and patent ductus arteriosus in a low-weight patient: A case report
Authors: Ma Yong-Yu , Chen Jun-Ru , Yang Shi-Wu , Wang Shu-Yu , Cao Xin , Wu Jun 
Published: January 2024

BACKGROUND
We report a low-birth-weight child (1.8 kg) with neonatal type III congenital esophageal atresia (CEA) combined with symptomatic patent ductus arteriosus (PDA). After comprehensive evaluation, esophageal anastomosis was performed on postnatal day 11 after excluding surgical contraindications, and arterial catheter ligation was performed at the same time. Concurrent surgery for CEA combined with PDA has not been clearly reported in the literature.
CASE SUMMARY
We report a 6-day-old female child with type III CEA and PDA. The patient presented with foam at the mouth after birth, cough and shortness of breath after feeding. At another hospital, she was considered to have neonatal pneumonia, neonatal jaundice and congenital heart disease and transferred to our hospital. After iodine oil radiography of the esophagus and echocardiography we confirmed diagnosis of CEA and PDA. The diameter of the PDA was 8 mm, with obvious left to right shunting. We performed right rear extrapleural orificium fistula ligation and esophageal anastomosis, and ligation of PDA via left axilla straight incision after 5 d of hospitalization. The operations were successful, and the incision healed after 12 d, and the patient was discharged. We re-examined the patient 1 mo after surgery. She did not vomit when she ate rice flour. Esophageal angiography showed no stricture of the anastomotic stoma. The patient weighed 3.2 kg.
CONCLUSION
For CEA patients with multiple risk factors, comprehensive, timely and accurate diagnosis and evaluation, and early treatment may improve prognosis.
Adult rhabdomyosarcoma combined with acute myeloid leukemia: A case report
Authors: Zheng Lu , Zhang Fen-Juan 
Published: January 2024

BACKGROUND
Rhabdomyosarcoma is a tumor of mesenchymal origin. Secondary leukemia is a complication of previous transformation to other hematologic disorders or is a treatment-related acute myeloid leukemia secondary to cytotoxic chemotherapy or radiation therapy for other malignancies.
CASE SUMMARY
We present the case of a 36-year-old female patient who was diagnosed with rhabdomyosarcoma and acute myeloid leukemia. Further disease progression was observed after multiline chemotherapy. Eventually, the patient suffered cerebral hemorrhage, which resulted in death.
CONCLUSION
The incidence of rhabdomyosarcoma in adults is extremely low, and secondary leukemia caused by rhabdomyosarcoma is even rarer. Secondary leukemia has a very poor prognosis and a low overall survival rate.