bluuebunny/crossref_metadata_2025_split huggingface dataset:
Assessment of the cranial involvement pattern of giant cell arteritis with 3t magnetic resonance imaging
Authors: Bley T. A. , Weiben O. , Uhl M. , Vaith P. , Schmidt D. , Warnatz K. , Langer M. 
Published: July 2005

AbstractObjectiveTo noninvasively determine the involvement pattern of the cranial arteries in giant cell arteritis (GCA), with high‐resolution magnetic resonance imaging (MRI).MethodsThe superficial cranial arteries of 21 patients with suspected GCA were examined using a 3T high‐field MRI scanner. Postcontrast T1‐weighted spin‐echo images were acquired with submillimeter spatial resolution, to assess mural thickness and lumen diameter of the major cranial arteries on both sides of the head. In all cases, MRI results were compared with findings of clinical examination and laboratory tests. In addition, temporal artery biopsy specimens from 10 patients were examined by histology.ResultsMRI sharply revealed all of the major superficial cranial arteries, allowing for an evaluation of their lumen and vessel wall. Nine of the 21 patients were diagnosed as having GCA according to the criteria of the American College of Rheumatology. In all of these patients with clinically diagnosed GCA, multiple cranial arteries showed signs of inflammation on MRI. In 1 patient, the occipital arteries were inflamed, while the temporal arteries were spared.ConclusionPostcontrast high‐resolution MRI visualizes the major cranial arteries on both sides of the head within a single examination. The cranial involvement pattern in GCA can be assessed precisely and noninvasively. In the majority of GCA patients, several cranial arteries were affected simultaneously, with a predominance of involvement of the frontal branch of the superficial temporal artery. Inflammation of the occipital arteries, with sparing of the temporal arteries, was also encountered.
Impact of disease severity and gastrointestinal side effects on the health state preferences of patients with osteoarthritis
Authors: Chang Jane , Kauf Teresa L. , Mahajan Shibani , Jordan Joanne M. , Kraus Virginia B. , Vail T. Parker , Reed Shelby D. , Omar Mohamed A. , Kahler Kristijan H. , Schulman Kevin A. 
Published: July 2005

AbstractObjectiveTo describe the health state preferences of patients with osteoarthritis (OA) according to the level of pain and disability and the extent of gastrointestinal side effects from nonsteroidal antiinflammatory drugs (NSAIDs).MethodsUsing combinations of 5 OA health states (4 specifying medication use) and 6 gastrointestinal side effect profiles, we developed 25 scenarios. In an Internet survey, adults with OA evaluated 5 randomly chosen health state–side effect scenarios (in addition to scenarios for congestive heart failure and wearing dentures, as benchmarks). They rated the scenarios on a 0–100 scale, in which 100 corresponds to best imaginable health. Unadjusted mean ratings were calculated using a difference‐in‐difference approach. A generalized linear model was used to estimate the effects of disease severity and side effect severity on the ratings, after controlling for patient characteristics.ResultsA total of 4,386 respondents whose mean age was 55.3 years, of whom 3,107 (70.8%) were women and 4,007 (91.4%) were white, completed the survey. Mean adjusted ratings for health state–side effect scenarios ranged from 94.9 for the mildest scenario to 25.3 for the most severe scenario. Severity of NSAID side effects had a greater negative influence on the ratings in milder OA states than in more severe OA states. Ratings were lower among men (P < 0.001) and among respondents with OA pain in the previous 24 hours (P < 0.001). Disease severity had a greater effect on ratings than did side effect severity.ConclusionPatients consider pain and functional limitations associated with OA to be important determinants of well‐being. Future research should attempt to determine whether patients prefer reductions in their OA‐related pain and disability over improvements in treatment side effect profiles.
Efficacy of infliximab in the treatment of uveitis that is resistant to treatment with the combination of azathioprine, cyclosporine, and corticosteroids in behçet's disease: An open‐label trial
Authors: Tugal‐Tutkun Ilknur , Mudun Abdulbaki , Urgancioglu Meri , Kamali Sevil , Kasapoglu Esen , Inanc Murat , Gül Ahmet 
Published: July 2005

AbstractObjectiveTo investigate the effect of infliximab on the frequency of uveitis attacks and the visual prognosis in male patients with Behçet's disease in whom uveitis was resistant to combination therapy with corticosteroids, azathioprine, and cyclosporine.MethodsThe study group comprised patients who were receiving combination therapy but experienced at least 2 attacks of posterior uveitis/panuveitis or retinal vasculitis during the 6‐month period prior to enrollment. Infliximab infusions (5 mg/kg) were administered at weeks 0, 2, 6, and 14. Weeks 0–22 were defined as the infusion period, and weeks 23–54 were defined as the observation period. Patients continued to receive azathioprine and corticosteroids, but cyclosporine was discontinued after the screening visit. The primary outcome measures were the absence of uveitis attacks during the infusion period (remission), and the absence of uveitis attacks throughout the study period (sustained remission).ResultsThirteen patients were enrolled in the study. Thirty‐two uveitis attacks involving the posterior segment occurred during the previous‐treatment period. During the infusion period, 4 patients (30.8%) remained attack‐free, and 9 patients had a total of 13 uveitis attacks. Ten of these attacks (76.9%) occurred at either week 14 or week 22. One of 13 patients fulfilled the definition of sustained remission, and the remaining 12 patients had a total of 36 uveitis attacks during the observation period. The mean number of uveitis attacks and daily corticosteroid doses were significantly lower during the infusion period than during the previous‐treatment period or the observation period. Although potential visual acuity was regained following infliximab infusion, this beneficial effect was not preserved until week 54. None of the patients experienced a serious adverse event.ConclusionThe results of this trial suggest that infliximab is effective in suppressing the occurrence of uveitis attacks, has a corticosteroid‐sparing effect, and has favorable implications for the visual prognosis of patients with resistant Behçet's uveitis.
Psoriasis induced by anti–tumor necrosis factor therapy: A paradoxical adverse reaction
Authors: Sfikakis P. P. , Iliopoulos A. , Elezoglou A. , Kittas C. , Stratigos A. 
Published: July 2005

AbstractAdministration of anti–tumor necrosis factor (anti‐TNF) agents is beneficial in a variety of chronic inflammatory conditions, including psoriasis. We describe 5 patients in whom psoriasiform skin lesions developed 6–9 months after the initiation of anti‐TNF therapy for longstanding, seropositive rheumatoid arthritis (etanercept or adalimumab), typical ankylosing spondylitis (infliximab), and Adamantiades‐Behçet's disease (infliximab). In all 5 patients, the underlying disease had responded well to anti‐TNF therapy. Four patients developed a striking pustular eruption on the palms and/or soles accompanied by plaque‐type psoriasis at other skin sites, while 1 patient developed thick erythematous scaly plaques localized to the scalp. In 3 patients there was nail involvement with onycholysis, yellow discoloration, and subungual keratosis. Histologic findings from skin biopsies were consistent with psoriasis. None of these patients had a personal or family history of psoriasis. In all patients, skin lesions subsided either with topical treatment alone, or after discontinuation of the responsible anti‐TNF agent. The interpretation of this paradoxical side effect of anti‐TNF therapy remains unclear but may relate to altered immunity induced by the inhibition of TNF activity in predisposed individuals.
The expression of toll‐like receptors 3 and 7 in rheumatoid arthritis synovium is increased and costimulation of toll‐like receptors 3, 4, and 7/8 results in synergistic cytokine production by dendritic cells
Authors: Roelofs M. F. , Joosten L. A. B. , Abdollahi‐Roodsaz S. , Van Lieshout A. W. T. , Sprong T. , van den Hoogen F. H. , Van Den Berg W. B. , Radstake T. R. D. J. 
Published: July 2005

AbstractObjectiveTo evaluate the expression of Toll‐like receptors (TLRs) 3 and 7 in synovium and to study potential differences in the maturation and cytokine production mediated by TLR‐2, TLR‐3, TLR‐4, and TLR‐7/8 by dendritic cells (DCs) from rheumatoid arthritis (RA) patients and DCs from healthy controls.MethodsSynovial expression of TLR‐3 and TLR‐7 in RA was studied using immunohistochemistry. Monocyte‐derived DCs from RA patients and healthy controls were cultured for 6 days and subsequently stimulated for 48 hours via TLR‐mediated pathways (lipoteichoic acid, Pam3Cys, and fibroblast‐stimulating lipopeptide 1 for TLR‐2, poly[I‐C] for TLR‐3, lipopolysaccharide and extra domain A for TLR‐4, and R848 for TLR‐7/8). Phenotypic DC maturation was measured using flow cytometry. The secretion of tumor necrosis factor α (TNFα), interleukin‐6 (IL‐6), IL‐10, and IL‐12 was measured using the Bio‐Plex system. Cell lines expressing TLR‐2 and TLR‐4 were used for the detection of TLR‐2 and TLR‐4 ligands in serum and synovial fluid from RA patients.ResultsTLR‐3 and TLR‐7 were highly expressed in RA synovium. All TLR ligands elicited phenotypic DC maturation equally between DCs from RA patients and those from healthy controls. TLR‐2– and TLR‐4–mediated stimulation of DCs from RA patients resulted in markedly higher production of inflammatory mediators (TNFα and IL‐6) compared with DCs from healthy controls. In contrast, upon stimulation of TLR‐3 and TLR‐7/8, the level of cytokine production was equal between DCs from RA patients and those from healthy controls. Remarkably, both TLR‐3 and TLR‐7/8 stimulation resulted in a skewed balance toward IL‐12. Intriguingly, the combined stimulation of TLR‐4 and TLR‐3–7/8 resulted in a marked synergy with respect to the production of inflammatory mediators. As a proof of concept, TLR‐4 ligands were increased in the serum and synovial fluid of RA patients.ConclusionTLRs are involved in the regulation of DC activation and cytokine production. We hypothesize that various TLR ligands in the joint trigger multiple TLRs simultaneously, favoring the breakthrough of tolerance in RA.
Valence State of Iron in the Sr2Fe(Mo,W,Ta)O6.0 Double‐Perovskite System: An Fe K‐Edge and L2,3‐Edge XANES Study.
Authors: Karppinen M. , Yamauchi H. , Yasukawa Y. , Linden J. , Chan T. S. , Liu R. S. , Chen J. M. 
Published: July 2005

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Electrochemistry of Niobium(V) in Sulfuric and Methanesulfonic Acids: Formation of the Nb3O2(SO4)6 (H2O)35‐ Cluster and Designed Electrochemical Generation of “Nb3O2” Core Clusters by Double Potential Pulse Electrolysis.
Authors: May Michael , Gantt Melissa , Hoadley Caroline , Batten Thomas , Sayers William , Katovic Vladimir 
Published: July 2005

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Gas‐Phase Hydration of U(IV), U(V), and U(VI) Dioxo Monocations.
Authors: Gresham Garold L. , Gianotto Anita K. , de B. Harrington Peter , Cao Libo , Scott Jill R. , Olsen John E. , Appelhans Anthony D. , Van Stipdonk Michael J. , Groenewold Gary S. 
Published: July 2005

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Highly Diastereoselective Addition of Et2AlCN to β‐Keto Amides Derived from (S)‐4‐Isopropyl‐2‐oxazolidinone.
Authors: Flores‐Morales Virginia , Fernandez‐Zertuche Mario , Ordonez Mario 
Published: July 2005

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An Efficient and Rapid Synthesis of β‐Carboxamide Derivatives Using 2,2‐Dimethyl‐2H,4H‐1,3‐dioxin‐4‐ones by Microwave Irradiation.
Authors: Miriyala Bruhaspathy , Williamson John S. 
Published: July 2005

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Regioselective 1,4‐Trifluoromethylation of α,β‐Enones Using “Protect‐in‐situ” Methodology.
Authors: Sevenard Dmitri V. , Sosnovskikh Vyacheslav Ya. , Kolomeitsev Alexander A. , Koenigsmann Martin H. , Roeschenthaler Gerd‐Volker 
Published: July 2005

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Highly Enantioselective Hydrogenation of Enamides Catalyzed by Rhodium‐Monodentate Phosphoramidite Complex Derived from H8‐BINOL.
Authors: Li Xingshu , Jia Xian , Lu Gui , Au‐Yeung Terry T.‐L. , Lam Kim‐Hung , Lo Thomas W. H. , Chan Albert S. C. 
Published: July 2005

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Fluorinated Hydrazones. Part 1. Reductive Coupling Reactions of Chlorodifluoroacetylated Dialkylhydrazones Using Tetrakis(dimethylamino)ethylene (TDAE).
Authors: Medebielle Maurice , Kato Katsuya , Dolbier William R. Jr. 
Published: July 2005

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Formation of 1,4‐Diketones via Bis‐acylation of the Conjugated Carbon—Carbon Double Bonds in Acrylates, Acrylamides, Methyl Vinyl Ketone and Styrenes with Aroyl Chlorides Promoted by Samarium Metal in DMF.
Authors: Liu Yongjun , Zhang Yongmin 
Published: July 2005

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A Convenient Method for the Preparation of Inverted tert‐Alkyl Carboxylates from Chiral tert‐Alcohols by a New Type of Oxidation—Reduction Condensation Using 2,6‐Dimethyl‐1,4‐benzoquinone.
Authors: Mukaiyama Teruaki , Shintou Taichi , Fukumoto Kentaro 
Published: July 2005

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Halosulfenylation of Conjugated Dienes with Arylsulfenamides in the Presence of Phosphorus Oxyhalides.
Authors: Beloglazkina E. K. , Belova M. A. , Antipin R. L. , Zyk N. V. , Buryak A. K. 
Published: July 2005

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Cyclodimerization of α,β‐Unsaturated Ketones Promoted by the TiCl4/Sm System.
Authors: Shi Daqing , Rong Liangce , Wang Juxian , Zhuang Qiya , Wang Xiangshan , Tu Shujiang , Hu Hongwen 
Published: July 2005

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A New Protocol for the in situ Generation of Aromatic, Heteroaromatic, and Unsaturated Diazo Compounds and Its Application in Catalytic and Asymmetric Epoxidation of Carbonyl Compounds. Extensive Studies to Map Out Scope and Limitations, and Rationalization of Diastereo‐ and Enantioselectivities.
Authors: Aggarwal Varinder K. , et al. et al. 
Published: July 2005

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Copper(I)‐Catalyzed Intramolecular Addition of N‐Chloroamides to Double Bonds: An Efficient Synthesis of Lactams from Unsaturated Amides.
Authors: Schulte‐Wuelwer Iris Anne , Helaja Juho , Goettlich Richard 
Published: July 2005

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2‐Aryl‐3‐phenylamino‐4,5‐dihydro‐2H‐benz[g]indazoles with Analgesic Activity.
Authors: Schenone Silvia , Bruno Olga , Ranise Angelo , Brullo Chiara , Bondavalli Francesco , Filippelli Walter , Mazzeo Filomena , Capuano Annalisa , Falcone Giuseppe 
Published: July 2005

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Studying the Synthesis of 4‐tert‐Butyl‐1,3‐dihydroimidazol‐2‐ones and Their Corresponding Thiones.
Authors: Loksha Yasser M. , Pedersen Erik B. , El‐Barbary Ahmed A. , El‐Badawi Mahmoud A. , Nielsen Claus 
Published: July 2005

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Solventless Reactions of 5(4H)‐Oxazolones with Umbelliferones and Selected Enolcarbonyl Compounds.
Authors: Cordaro Massimiliano , Di Donna Leonardo , Foti Francesco , Grassi Giovanni , Napoli Anna , Risitano Francesco , Sindona Giovanni 
Published: July 2005

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Synthesis and in vitro Pharmacology of Novel Heterocyclic Muscarinic Ligands.
Authors: De Amici Marco , Conti Paola , Fasoli Ezio , Barocelli Elisabetta , Ballabeni Vigilio , Bertoni Simona , Impicciatore Mariannina , Roth Bryan L. , Ernsberger Paul , De Micheli Carlo 
Published: July 2005

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Regio‐ and Stereoselective Preparation of γ‐Alkylidenebutenolides or α‐Pyrones Using a Stille Reaction and Palladium‐Catalyzed Oxacyclization Sequence.
Authors: Rousset Severine , Abarbri Mohamed , Thibonnet Jerome , Parrain Jean‐Luc , Duchene Alain 
Published: July 2005

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2‐(Dialkylamino)‐4H‐1‐benzopyran‐4‐one Derivatives Modify Chloride Conductance in CFTR Expressing Cells.
Authors: Mazzei Mauro , Nieddu Erika , Folli Chiara , Caci Emanuela , Galietta Louis V. J. 
Published: July 2005

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Highly Enantioselective Iridium‐Catalyzed Hydrogenation of Heteroaromatic Compounds: Quinolines.
Authors: Wang Wen‐Bo , Lu Sheng‐Mei , Yang Peng‐Yu , Han Xiu‐Wen , Zhou Yong‐Gui 
Published: July 2005

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Novel “Quinolone” Metal Complexes: Synthesis and Spectroscopic Studies of Mg(II), Zn(II), and Ba(II) Complexes with N‐Methyl (or NH)‐3‐Acetyl‐4‐hydroxy Quinolin‐2‐one Ligands.
Authors: Athanasellis Giorgos , Gavrielatos Efstathios , Igglessi‐Markopoulou Olga , Markopoulos John 
Published: July 2005

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Towards New Neuroprotective Agents: Design and Synthesis of 4H‐Thieno[2,3‐c]isoquinolin‐5‐one Derivatives as Potent PARP‐1 Inhibitors.
Authors: Pellicciari Roberto , Camaioni Emidio , Constantino Gabriele , Marinozzi Maura , Macchiarulo Antonio , Moroni Flavio , Natalini Benedetto 
Published: July 2005

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Synthesis of 3‐ or 4‐Phenyl‐1,8‐naphthyridine Derivatives and Evaluation of Antimycobacterial and Antimicrobial Activity.
Authors: Badawneh Muwaffag , Bellini Laura , Cavallini Tiziana , Al Jamal Jalal , Manera Clementina , Saccomanni Giuseppe , Ferrarini Pier Luigi 
Published: July 2005

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Aromatic Nucleophilic Substitution in 1,2,4‐Triazine 4‐Oxides with Grignard Reagents.
Authors: Prokhorov A. M. , Kozhevnikov D. N. , Rusinov V. L. , Chupakhin O. N. 
Published: July 2005

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4,4,6‐Trimethyl‐2‐vinyl‐1,3,2‐dioxaborinane: A Superior 2‐Carbon Building Block for Vinylboronate Heck Couplings.
Authors: Lightfoot Andrew P. , Maw Graham , Thirsk Carl , Twiddle Steven J. R. , Whiting Andrew 
Published: July 2005

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seco‐Iridoids from Calycophyllum spruceanum (Rubiaceae).
Authors: Zuleta Luz Margarita Cardona , Cavalheiro Alberto Jose , Silva Dulce Helena Siqueira , Furlan Maysa , Young Maria Claudia Marx , Albuquerque Sergio , Castro‐Gamboa Ian , da Silva Bolzani Vanderlan 
Published: July 2005

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Synthesis and Crystal Structure of a New Methoxytrichloro Derivative of Achillin.
Authors: Alebastrov O. V. , Raldugin V. A. , Bagryanskaya I. Yu. , Gatilov Yu. V. , Shakirov M. M. , Kulyjasov A. T. , Adekenov S. M. 
Published: July 2005

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Synthetic Study of Optically Active 3‐Azabicyclo[3.3.0]octane‐2,6,8‐tricarboxylic Acid.
Authors: Arakawa Yasushi , Ohnishi Masafumi , Yoshimura Norikazu , Yoshifuji Shigeyuki 
Published: July 2005

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The Synthesis of Isoquinoline Alkaloid and Its Related Compounds Using Alanine Derivatives as Chiral Auxiliaries.
Authors: Itoh Takashi , Nagata Kazuhiro , Yokoya Masashi , Miyazaki Michiko , Kameoka Keiko , Nakamura Shigeru , Ohsawa Akio 
Published: July 2005

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Properties of Triple Helices Formed by Oligonucleotides Containing 8‐Aminopurines
Authors: Avino A. , Frieden M. , Morales J. C. , de la Torre B. G. , Gueimil‐Garcia R. , Orozco M. , Gonzalez C. , Eritja R. 
Published: July 2005

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Labeling During Cleavage of Nucleic Acids for Their Detection on DNA Chips
Authors: Laayoun A. , Sothier I. , Menou L. , Bernal‐Mendez E. , Kotera M. , Bourget C. , Trevisiol E. , Lhomme J. , Troesch A. 
Published: July 2005

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Synthesis of (Z)‐(1‐Fluoro‐2‐hydroxymethylcyclopropylmethyl)purines
Authors: Park Ju‐Hyun , Lee Young Rang , Chun Moon Woo , Jeong Lak Shin , Lee Chong‐Kyo , Kim Hee‐Doo 
Published: July 2005

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Curtisians E—H: Four p‐Terphenyl Derivatives from the Inedible Mushroom Paxillus curtisii.
Authors: Quang Dang Ngoc , Hashimoto Toshihiro , Nukada Makiko , Yamamoto Isao , Tanaka Masami , Asakawa Yoshinori 
Published: July 2005

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Biologically Active Alkylated Coumarins from Kayea assamica.
Authors: Lee Kyung‐Hee , Chai Hee‐Byung , Tamez Pamela A. , Pezzuto John M. , Cordell Geoffrey A. , Win Khin Khin , Thin‐Wa Maung 
Published: July 2005

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Microwave‐Assisted Polyol Synthesis of CuInTe2 and CuInSe2 Nanoparticles.
Authors: Grisaru Haviv , Palchik Oleg , Gedanken Aharon , Palchik Valery , Slifkin Michael A. , Weiss Arie M. 
Published: July 2005

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Cooling‐Rate Dependent Ferromagnetism in a Two‐Dimensional Cyano‐Bridged Sm(III)—W(V) Complex.
Authors: Hozumi Toshiya , Ohkoshi Shin‐ichi , Arimoto Yoichi , Seino Hidetake , Mizobe Yasushi , Hashimoto Kazuhito 
Published: July 2005

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Synthesis, Structure and Magnetic Properties of a New Iron Arsenate, [C10N4H28] [{FeF(OH)(HAsO4)}4], with a Layer Structure.
Authors: Chakrabarti Sandip , Pati Swapan K. , Green Mark A. , Natarajan Srinivasan 
Published: July 2005

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Enantioselective Borohydride Reduction Catalyzed by Optically Active Cobalt Complexes.
Authors: Yamada Tohru , Nagata Takushi , Sugi Kiyoaki D. , Yorozu Kiyotaka , Ikeno Taketo , Ohtsuka Yuhki , Miyazaki Daichi , Mukaiyama Teruaki 
Published: July 2005

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Co(thd)2: A Superior Catalyst for Aerobic Epoxidation and Hydroperoxysilylation of Unactivated Alkenes: Application to the Synthesis of Spiro‐1,2,4‐trioxanes.
Authors: O'Neill Paul M. , Hindley Stephen , Pugh Matthew D. , Davies Jill , Bray Patrick G. , Park B. Kevin , Kapu Dauda S. , Ward Stephen A. , Stocks Paul A. 
Published: July 2005

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Hydroxyapatite‐Bound Cationic Ruthenium Complexes as Novel Heterogeneous Lewis Acid Catalysts for Diels—Alder and Aldol Reactions.
Authors: Mori Kohsuke , Hara Takayoshi , Mizugaki Tomoo , Ebitani Kohki , Kaneda Kiyotomi 
Published: July 2005

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Preparation of Enol Ethers by Carbonyl Olefination Utilizing an Alkoxymethyl Chloride—Titanocene(II) System.
Authors: Takeda Takeshi , Shono Tomohiro , Ito Kenji , Sasaki Hironori , Tsubouchi Akira 
Published: July 2005

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Progressive Studies on the Novel Samarium‐Catalyzed Diastereoselective Tandem Semipinacol Rearrangement/Tishchenko Reduction of Secondary α‐Hydroxy Epoxides.
Authors: Fan Chun‐An , Hu Xiang‐Dong , Tu Yong‐Qiang , Wang Bao‐Min , Song Zhen‐Lei 
Published: July 2005

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Novel Concepts in Directed Biaryl Synthesis. Part 107. Synthesis of Enantiopure Axially Chiral C3‐Symmetric Tripodal Ligands and Their Application as Catalysts in the Asymmetric Addition of Dialkylzinc to Aldehydes.
Authors: Bringmann Gerhard , Pfeifer Robert‐Michael , Rummey Christian , Hartner Kristina , Breuning Matthias 
Published: July 2005

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