bluuebunny/crossref_metadata_2025_split huggingface dataset:
Female sex hormones enhance the negative effects of air pollution on lung cells
Authors: Smelan J. W , Frias D. P. , Oliveira J. N.A , Strauss B , Antunes F. , Teodoro W. R. , Mauad T , Macchione M 
Published: January 2024

Abstract
This study aims to investigate whether diesel exhaust particles (DEP) alone or associated with the hormones 17β-estradiol (E2) and progesterone (P4) can interact and alter cellular responses in the hormones and xenobiotic pathways in human bronchial cells (BEAS-2B) and human lung carcinoma (A549) in the following conditions: control (CT); 10 µg/ml DEP; 1 nM E2; 10 nM P4; 1 nM E2+ 10 µg/ml DEP and 10 nM P4+ 10 µg/ml DEP with 72 hours for hormones and 8 hours for DEP. Were studied the expression and localization of ERβ, PRβ and AhR receptors, using the immunofluorescence technique; the activation of the promoter regions ERE, PRE and XRE was using the luciferase “reporter” gene assay and were measured the following cytokines: GM-CSF, IL-6, IL-10, IL-1B, RANTES and TNF-α to determine the inflammatory response using the multiplex assay. The results showed ERβ, PRβ and AhR translocation from cytoplasm to nucleus in the presence of E2 and E2+DEP, to both cells, but the same did not occur when BEAS-2B were exposed P4 + DEP. The results related with XRE and PRE showed activation of their promoter region when cells were exposed to DEP and showed a promoter inhibition response to DEP + P4. ERE did not show any significant response. The exposition of E2 and E2+DEP increased pro-inflammatory cytokines in BEAS-2B while DEP and E2+DEP increased pro-inflammatory cytokines in A549 and the anti-inflammatory cytokine IL-10 responded to E2 in both cells. BEAS-2B present their cellular responses more intensely when exposed to E2 + DEP and an increase in the expression of ERβ and PR receptors with concomitant increase in inflammatory cytokines GM-CSF, IL-6 and TNF-α. ERE promoter region was not activated, but it does not indicate that DEP does not interfere with the oestrogen pathway, maybe for another way. As conclusion, this study corroborates the hypothesis that air pollution interferes with the pathways of female sex hormones, potentially interfering with the health of the population, especially women.
P123-CoMgAl nanocomposite for sustainable and high-conversion epoxide ring-opening polymerization
Authors: Xu Xiao , Cao Xiaoyan , Yang Yipeng , Chen Fangyi , Gu Zhenggui 
Published: January 2024

Abstract
The ring-opening polymerization lays the foundation for synthesizing polypropylene glycol (PPG). Nevertheless, homogeneous alkali catalysts generally necessitate intricate posttreatments, hampering green synthesis and ensuring environmental sustainability. Here, we develop a heterogeneous epoxide polymerization method based on a P123-modified nanocomposite layered double oxide (CoMgAl-LDO (P123)). Benefiting from the designable and self-assembled P123 micelles, CoMgAl-LDO (P123) yields intergranular gaps and consistent mesoporous channels for effective catalysis. Consequently, CoMgAl-LDO (P123) has a large surface-to-volume ratio of 190.0 m2 g− 1 and a pore volume of 1.0 cm3 g− 1. More importantly, the epoxide catalytic conversion approaches 96.3%, which is higher than the 92% conversion of other solid catalysts. Our strategy addresses the trade-off issue that alkali catalysts face in terms of sustainability and operational complexity, holding great promise in green chemistry.
Expanding the phenotypic spectrum of NOTCH1 variants: Clinical manifestations in families with congenital heart disease
Authors: Jobling Rebekah , Stanley Kaitlin , Kalbfleisch Kelsey , Moran Olivia , Chaturvedi Rajiv , Roifman Maian , Manshaei Roozbeh , Martin Nicole , McDermott Simina , McNiven Vanda , Myles-Reid Diane , Nield Lynne , Reuter Miriam , Schwartz Marci , Shannon Patrick , Silver Rachel , Somerville Cherith , Teitelbaum Ronni , Zahavich Laura , Bassett Anne , Kim Raymond , Mital Seema , Chitayat David 
Published: January 2024

Abstract

Pathogenic variants in NOTCH1 are associated with non-syndromic congenital heart disease (CHD) and Adams-Oliver syndrome (AOS). The clinical presentation of individuals with damaging NOTCH1 variants is characterized by variable expressivity and incomplete penetrance; however, data on systematic phenotypic characterization are limited. We report the genotype and phenotype of a cohort of 33 individuals (20 females, 13 males; median age 23.4 years, range 2.5–68.3 years) from 11 families with causative NOTCH1 variants (9 inherited, 2 de novo; 9 novel), ascertained from a proband with CHD. We describe the cardiac and extracardiac anomalies identified in these 33 individuals, only one of whom met criteria for AOS. The most common CHD identified was tetralogy of Fallot, though various left- and right-sided lesions and septal defects were also present. Extracardiac anomalies identified include cutis aplasia (5/33), cutaneous vascular anomalies (7/33), vascular anomalies of the central nervous system (2/10), Poland anomaly (1/33), pulmonary hypertension (2/33), and structural brain anomalies (3/14). Identification of these findings in a cardiac proband cohort supports NOTCH1-associated CHD and NOTCH1-associated AOS lying on a phenotypic continuum. Our findings support: 1) Broad indications for NOTCH1 molecular testing (any familial CHD, simplex tetralogy of Fallot or hypoplastic left heart); 2) Cascade testing in all at-risk relatives; and 3) A thorough physical exam, in addition to cardiac, brain (structural and vascular), abdominal, and ophthalmologic imaging, in all gene positive individuals. This information is essential for guiding the medical management of these individuals, particularly given the high prevalence of NOTCH1 variants in the CHD population.
Risk factors for subchondral bone alterations in temporomandibulat joint arthralgia: a retrospective multivariate CBCT study
Authors: Emshoff Rüdiger , Rudisch Ansgar , Bertram Stefan 
Published: January 2024

Abstract

Objectives
Temporomandibular joint (TMJ) osteoarthritis (OA) is a progressive degenerative joint disorder characterized by loss of cartilage and alterations in subchondral bone architecture. Prospective studies using multivariable analysis to identify risk factors for subchondral bone alterations (SBAs) are lacking. The aim of this study was to identify clinical baseline predictors mostly associated with the severity of TMJ condylar SBAs.
Materials and methods
This retrospective paired-design study enrolled 233 consecutive TMJ pain patients. TMJ pain patients were classified according to the diagnostic criteria for temporomandibular disorders (DC/TMD) Axis I protocol. Following clinical examination, each patient underwent cone beam computed tomography (CBCT) evaluation of both TMJs. A composite condylar SBA grading score was created from the following items: erosion, resorption, cyst, sclerosis, osteophyte, and flattening; the maximum possible score was 4. Multivariate ordinal regression analysis identified baseline predictors of CBCT condylar SBA grades.
Results
The study group included 87.6% women, and the overall average age of the study population was 41.9 ± 18.1 years. The following factors were significantly associated with the severity of condylar SBAs: older age (> 45 years) (odds ratio [OR], 4.53; p < 0.001), having concomitant arthralgia (OR, 1.85; p = 0.035), and higher number of missing posterior teeth (> 4) (OR, 1.80; p = 0.039). Gender (p = 0.080) and time since pain onset (p < 0.05) had no significant association with condylar SBA grade.
Conclusions
Older age, concomitant arthralgia, and a higher number of missing posterior teeth were related to the severity of TMJ condylar SBAs.
Clinical relevance
Older patients with missing posterior teeth who have a concurrent arthralgia should be advised of their increased risk of developing SBAs. Delayed diagnosis and treatment can be avoided by focusing on these risk factors.
A qualitative interview study to determine barriers and facilitators of implementing automated decision support tools for genomic data access
Authors: Rahimzadeh Vasiliki , Baek Jinyoung , Lawson Jonathan , Dove Edward S. 
Published: January 2024

Abstract

Data access committees (DAC) gatekeep access to secured genomic and related health datasets yet are challenged to keep pace with the rising volume and complexity of data generation. Automated decision support (ADS) systems have been shown to support consistency, compliance, and coordination of genomic data sharing of data access review decisions. However we lack understanding of how DAC members perceive the value add of ADS, if any, on the quality and effectiveness of their reviews. In this qualitative study, we report findings from 13 semi-structured interviews with DAC members from around the world to identify relevant barriers and facilitators to implementing ADS for genomic data access management. Participants generally supported pilot studies that test ADS performance for example in cataloging data types, verifying user credentials and tagging datasets for use terms. Concerns related to over-automation, lack of human oversight, low prioritization, and misalignment with institutional missions tempered enthusiasm for ADS among the DAC members we engaged. Tensions for change in institutional settings within which DACs operated was a powerful motivator for why DAC members considered the implementation of ADS into their access workflows, as well as perceptions of the relative advantage of ADS over the status quo. Future research is needed to build the evidence base around the comparative effectiveness and decisional outcomes of institutions that do/not use ADS into their workflows.
The analysis of bioinformatics uncovers the interaction genes and immune connection between the fracture and CRPS
Authors: Kong Yan , Wang Jian , Guo Qulian , Luo Sumei , Ding Zhuofeng 
Published: January 2024

Abstract

Background
Patients with fractures are known to have an increased susceptibility to the development of complex regional pain syndrome (CRPS), yet the precise underlying mechanism of this condition remains inadequately understood. The objective of this study is to identify shared genes between fracture and CRPS and explore their potential molecular mechanisms.
Methods
The raw data pertaining to facture and CRPS were obtained from the Gene Expression Omnibus (GEO) datasets. Venn plots were utilized to extract the differentially expressed genes (DEGs) that were shared between facture and CRPS. Subsequently, functional enrichment analyses were conducted on these shared genes to identify significant biological functions. The PPI network was employed to visualize the network of the shared genes, and the hub genes were identified using MCODE. The levels of immune infiltration in fracture and CRPS were evaluated using the CIBERSORT algorithm, and the relationship between hub genes and immune cell infiltration was investigated. Additionally, the expression levels of hub genes were examined to explore potential phenotypic subgroups in fractures and CRPS, and the infiltration of immune cells was analyzed across different subcategories.
Results
A comprehensive analysis revealed the presence of 13 overlapping genes among the DEGs in the fracture and CRPS datasets. The outcomes of functional enrichment analysis suggest that these shared genes primarily participate in immune-related pathways. Furthermore, our investigation identified five hub genes that exhibited up-regulation in both CRPS and fracture patients when compared to healthy individuals. The analysis of immune infiltration revealed an increase in various immune cell populations among patients diagnosed with CRPS and fractures. Furthermore, the hub genes exhibited strong associations with multiple infiltrating immune cells. Based on their shared gene expression profiles, patients with fractures and CRPS were classified into two distinct clusters, namely C1 and C2.
Conclusion
Our study reveals a close relationship between fracture and CRPS from crosstalk genes, providing clues to further explore the interaction and therapy for fracture and CRPS.
The Correlation between Corneal Shaping Force and Corneal Biological Parameters in Adolescents
Authors: Yu Jia , Zhou Yuehua , Guo Yujuan 
Published: January 2024

Abstract

Purpose
This study aimed to analyze the influence of corneal parameters on the corneal shaping force.
Methods
This retrospective study enrolled 189 patients. According to the different spherical equivalent(SE), grouping as: A, SE≤-2.0D; B,> -2.0D and≤-3.0D; C, > -3.0D and≤-4.0D; D, > -4.0D and≤-5.5D。Some parameters were measured before OK was worn. The shaping force is the difference between the equivalent spheres before and after wearing OK.
Results
One day post-OK, △SE of A was significantly associated with hexagonal cells(6A); B were associated with Em and coefficient of variation (CV); C was associated with horizontal curvature radius(rf); D were associated with height difference and corneal biomechanical index (TBI); in multivariate analyses, △SE were associated with SE and total corneal thickness. For one week, C was associated with the corneal biomechanical index(TBI), and D was associated with rf and Em (P < 0.05). In the multivariate analyses,△SE was associated with SE,SRI, and total corneal thickness(P < 0.001).
Conclusions
The factors affecting the corneal shaping force under different SE were different, and different analyses should be performed on the individualized corneal parameters of children.
Dense Granular Flow Described by Micropolar Fluid and Its Peridynamic Implementation
Authors: Wan Ji , Qu Wenzhong , Chu Xihua 
Published: January 2024

Abstract

This work presents a nonlocal mesh-free peridynamic model for micropolar fluids that describe fluids enriched with the micro-rotational and length scale effects. The stabilized force state is applied to remedy the zero-energy mode instability in the micropolar viscous term. The present model is validated with the planar Couette flow and Poiseuille flow simulation. Considering the natural inheritance of micro-spinning and microstructures in granular flows, the peridynamic micropolar fluid model is also applied to simulate the dense, dry granular flow with a modified µ(I) rheology flow law. The effects of the coupling number, the micro-inertia, and the characteristic length on the granular µ(I) flow are discussed in a two-dimensional column collapse example. The numerical results of column collapse show that the micropolar coupling number can significantly affect column collapse behavior. A larger coupling number can slow down the translational movement of the granular flow, resulting in a larger angle of repose. The micro-rotational velocity increases by enlarging the coupling number. The micro-inertia and characteristic length have a significant influence on the micro-rotational behavior of the granular flow. Increasing either micro-inertia or characteristic length value decreases the micro-rotational velocity. However, the characteristic length and micro-inertia have an insignificant influence on the translational behavior. Slight differences are observed in the translational velocity distribution or free surface profile.
Design of Zigbee Adaptive Wireless Sensor Network Based on RSSI Predictive Value
Authors: Jin Zhu , Hao Wu 
Published: January 2024

Abstract

WSN (Wireless Sensor Network) is the technology used for sensors and communication devices to monitor data, which is characterized by low power consumption, miniaturization, and low cost. The QoS（Quality of Service） of the WSN is an important index to measure its performance, the moving characteristics of the human body and the working environment all affect the quality of the link, so that the RSSI (Received Signal Strength Indicator) is disturbed and the QoS is declined. To solve the above problems, This paper constructs an RPG-RGMM (Reference Point Group-Random Gauss-Markov Human Mobility Model) model considering the mobile characteristics of the human body, and investigates the RSSI decay pattern of ZigBee nodes moving with the body under the influence of the human body movement and the surrounding environment. The RSSI prediction value is used as an influence factor to update the selection of the relay node in the transmission management, forming an adaptive topology routing strategy. The results of the experiment demonstrate a decrease in the total packet loss rate of the adaptive topology routing strategy based on the RSSI prediction value of 10.61% compared to the traditional routing strategy. From a long-term perspective, this application has a good practical value.
Effect of Anxiety and Depression on the Outcome of Infertility Treatment Among Women in Sudan: a Multi Center Cross-sectional Study
Authors: Abdelseid Hadeel Mohamed Muaid , Awadallah Hiba Yousif Merghani , Ellahawi Alaa Merghani Babiker , Mohammed Hajer Abdalmonem Abdullah , Ali Gadeer Khalil Osman , Ali Rayan Abdo Ibrahim Adam , Ahmed Tarteel Abdelrahim Elobeid , Mohamedalnour Areej Ahmed Ali , Elnour Abdulhay Bushra Mohamed Mohamed , Handady Siddig Omer Mohammed , Osman Suliman 
Published: January 2024

Abstract

Background and objectives: Infertility and its treatment have been linked to psychological distress, and many couples experience significant stress throughout treatment cycles that might affect their relationship. An Ethiopian study indicated that the incidence of infertility-related stress was 92.7% in 2022, which is concerning for couples seeking therapy as they believe that stress may have an impact on the success of their treatment. The purpose of this study was to investigate the effect of the psychological burden on the treatment outcome of infertility among Sudanese women in Khartoum state.
Methods: The study was performed at 4 infertility treatment centers in Khartoum State. Data were collected using an interviewer-structured Hamilton anxiety rating scale (HAM-A) for assessment of anxiety level and Beck's depression inventory (BDI) for depression, considering some demographic variables (age, occupation, duration of marriage, annual income, and pregnancy test results). Women who sought infertility treatment were recruited and consented to participate in the study.
Results: One hundred fifty-eight participants were interviewed, majority aged between 31–35 years and 36–40 years of age, with a percentage of 27.2% and 22.2% respectively. Most of the participants (53.8%) were housewives and 85.4% of their annual income was from moderate socio-economical level. Primary infertility causes were found in 57.0% with 36.7% due to male factors, 24.1% due to female factors, only 13.3% due to combined causes, and 25.9% unexplained. No significant association was found between pregnancy tests and other women's demographics and social characteristics, except for the annual income (p = 0.046).
According to BDI, severe depression was found in 13.3% and 8.2% of severe anxiety reported according to Hamilton. However, both anxiety and depression scales had no significant statistical association between pregnant and non-pregnant women (p = 0.462 and p = 0.059, respectively)
Conclusion: Women who faced psychological stress in terms of anxiety or depression do not have a diminished chance to have a baby; however, further research must be done on a larger scale.
Exercise Level and Its Related Factors in Patients with Colorectal Cancer Comorbid Diabetes Mellitus undergoing Chemotherapy（a cross-sectional study）
Authors: Liu Huan , Zhao Huihua , Yang Zhuojun , Gu Yi , Zhang Wen , Zhou Jiao , Yang Yang , Li Haiyan , Zhu Renmin 
Published: January 2024

Abstract

Aim
To investigate the status quo of exercise management as well as its related factors among patients with colorectal cancer comorbid diabetes mellitus to provide reference for clinical exercise intervention programs.
Methods
A cross-sectional study of 124 patients with colorectal cancer comorbid diabetes mellitus who were undergoing chemotherapy in Shanghai from December, 2022 to April, 2023, was undertaken. Two self-made questionnaires were used to investigate the exercise management and its related factors, and multiple linear regression analysis was used to explore the potential related factors.
Results
The mean amount of exercise per week was 3.70 ± 3.50 MET-h/week. The stepwise regression results revealed that exercise level was positively correlated with motor function (r = 0.305, p = 0.001), self-efficacy (r = 0.582, p = 0.000), social support (r = 0.434, p = 0.000), and health behavior change techniques (r = 0.419, p = 0.000).
Conclusion
The current status of exercise management in patients with colorectal cancer comorbid diabetes mellitus during chemotherapy is pessimistic and contradictory. It is urgent to pay attention to the influence of comorbidity on exercise. Sex, adverse reactions of chemotherapy, self-efficacy, motor function and social support have the greatest influence on their level of exercise.
An experimental and theoretical investigation on the hyper- viscoelasticity of polyamide 12 produced by selective laser sintering
Authors: Kadkhodaei Mahmoud , Pawlikowski Marek , Drobnicki Rafał , Domański Janusz 
Published: January 2024

Abstract

Polyamide 12 (PA12) is vastly utilized in many additive manufacturing methods, such as Selective Laser Sintering (SLS), and a better understanding of its mechanical behaviors promotes available knowledge on the behaviors of 3D-printed parts made from this polymer. In this paper, SLS-produced standard tensile samples are studied under monotonic and cyclic tension tests, as well as stress relaxation experiments, and the obtained force-displacement responses are shown to be consistent with a hyper-viscoelastic material model. This finding is also observed in typical pantographic structures produced by the same manufacturing parameters. To propose a constitutive model for predicting these behaviors, the convolution integral of a strain-dependent function and a time-dependent function is developed where the material parameters are determined with the use of both short-term and long-term responses of the specimens. Numerical results of the presented model for standard test samples are shown to be in good agreements with the experimental ones under various loading conditions. To prove the capabilities of the proposed model in studying any SLS-produced part, finite element implementation of the constitutive equations is shown to provide numerical results in agreement with the empirical findings for tensile loading of the 3D-printed pantographic structure.
Improving the Linear and Nonlinear Optical Properties of Two Laser Dyes, Pure Rhodamine B and Methyl Violet by Mixing them
Authors: Ali Fadhel H. , almaamori Mohammed Hamza , Jasim Saad Abbas , K M. Jawad , Hameed Saif H. , Aliwi Karrar k. , Hussein Ammar , Aliwi Muhammad R. 
Published: January 2024

Abstract

The present research include studying the structural ,linear and nonlinear optical properties for two organic laser dyes: Rhodamine B (RB) and Methyl violet (10B) The linear optical properties for all prepared samples have been studied, a study of UV-VIS spectra for different concentrations for each dye dissolved in absolute ethanol solvent, then study of absorption and transmission spectra for all samples. The spectral optical properties of all the prepared samples have been studied using fluorescence spectroscopy. The results showed when the concentrations increased the absorbance also increased for the same wavelength. The opposite relationship was observed for transmittance.