bluuebunny/crossref_metadata_2025_split huggingface dataset:
Unpacking the Safe Third Country Concept in the European Union: B/orders, Legal Spaces, and Asylum in the Shadow of Externalization
Authors: Osso Berfin Nur 
Published: December 2023

Abstract
Since its origins in the 1980s, the concept of safe third country (STC) has increasingly been used to deter and curb ‘irregular migrant’ arrivals. A burgeoning body of research has considered these measures throughout the world, particularly in the European Union (EU), Canada, Australia, and the United States. While much STC scholarship has been doctrinal in nature and has focused on the protection standards required in a third State, some of the literature has also examined more theoretical questions. Against this background, this article explores the consequences of the STC concept for refugees and their (in)ability to seek and enjoy asylum by drawing on critical border studies literature. The article first conceptualizes this concept with reference to theories of bordering, dissecting the STC concept as a bordering tool which constructs subjects as worthy and unworthy of protection, and decides where the latter are to be protected. It then explores how this concept has been operationalized within the EU’s Common European Asylum System and the implications of this phenomenon for refugees, using the Greek–Turkish context as a case study. The article particularly considers the developments after the EU–Türkiye Statement of 18 March 2016 and a joint ministerial decision of 8 June 2021 by which Greece formally designated Türkiye as a STC. It reveals that while these measures came in response to the so-called irregular arrivals at the Greek–Turkish border, thousands of refugees affected by these measures have been either removed from the Greek territory and returned to Türkiye without protection, or trapped in limbo in Greece because of their removal from the EU asylum system. The article demonstrates that the STC concept, which is increasingly used as a bordering practice, spatially and temporally prevents certain people from being recognized and treated as refugees in accordance with the Refugee Convention.
Corrigendum to “K-theoretic Characterization of C*-algebras with Approximately Inner Flip”
Authors: Enders Dominic , Schemaitat André , Tikuisis Aaron 
Published: December 2023

Abstract
An error in the original paper is identified and corrected. The $\textrm {C}^{\ast }$-algebras with approximately inner flip, which satisfy the UCT, are identified (and turn out to be fewer than what is claimed in the original paper). The action of the flip map on K-theory turns out to be more subtle, involving a minus sign in certain components. To this end, we introduce new geometric resolutions for $\textrm {C}^{\ast }$-algebras, which do not involve index shifts in K-theory and thus allow for a more explicit description of the quotient map in the Künneth formula for tensor products.
Postoperative hemorrhage after Le Fort I osteotomy hemostasis with angiographic embolization: report of two cases
Authors: Yun Yasutaka , Kurasawa Shiro , Morita Mizuki , Kawachi Risaki , Murata Hideyuki , Sawada Shunsuke , Kojima Yuka , Yagi Masao , Asako Mikiya , Iwai Hiroshi 
Published: December 2023

Abstract
This study reported two cases of acute life-threatening hemorrhage after Le Fort I osteotomy. In both cases, computed tomography and angiography revealed damage to the descending palatine artery, which was successfully treated by angiographic embolization. Although massive hemorrhage after Le Fort I osteotomy is rare, acute hemorrhage from the postoperative area may occur. Angiographic embolization is useful in cases of such hemorrhage from the posterior nasal cavity where endoscopic hemostasis is not possible.
Excision and reconstruction of dorsal nasal mucous cyst using dorsal nasal flap technique: a case report and literature review
Authors: Ahmed Mohamed B , Al-Mohannadi Fatima S , Elzawawi Khaled E , Alsherawi Abeer , Althalathini Mahmoud 
Published: December 2023

Abstract
Congenital nasal masses are very rare presentations. Among these masses is a mucous cyst, which might be considered either a congenital or an acquired mass. Our report presents a case of recurrent dorsal nasal swelling that was initially managed with an open rhinoplasty. However, 1 year after the surgery, the swelling started to grow rapidly, and the patient presented with a disfigured nose. We scheduled the patient for the excision of the dorsal nasal swelling and reconstruction using the dorsal nasal flap approach. Several surgical techniques have been performed and published in the literature; however, this is the first time the dorsal nasal flap technique is being reported as a surgical approach to dorsal nasal mucous cysts. While mucous cyst formation might be congenital, the majority occur after rhinoplasty surgery. However, they can be prevented by minimizing unnecessary trauma during the surgery and ensuring the thorough removal of all epithelial tissue and foreign bodies.
Ischemic hepatitis due to an occlusion of visceral arteries: a case report
Authors: Omran Safwan , Greiner Andreas 
Published: December 2023

Abstract
Ischemic hepatitis due to mesenteric artery occlusion is extremely rare. This is due to the function of the collateral network of the celiac–mesenteric arterial system and portal venous flow. A 64-year-old male presented with abdominal pain, a significantly reduced general condition, a weight loss of 20 kg in 4 months. Computed tomography showed occlusion of the celiac trunk and the superior mesenteric artery and hypodense lesions in the liver. We performed an antegrade visceral reconstruction with a bifurcated 12-6 mm Dacron graft from the supra-celiac aortic donor to the superior mesenteric and celiac arteries. The postoperative course and follow-up were uneventful.
Hepatic TRPC3 loss contributes to chronic alcohol consumption-induced hepatic steatosis and liver injury in mice
Authors: Ding Qinchao , Guo Rui , Hao Liuyi , Song Qing , Fu Ai , Lai Shanglei , Xu Tiantian , Zhuge Hui , Chang Kaixin , Chen Yanli , Wei Haibin , Ren Daxi , Sun Zhaoli , Song Zhenyuan , Dou Xiaobing , Li Songtao 
Published: December 2023

Abstract
Emerging evidence discloses the involvement of calcium channel protein in the pathological process of liver diseases. Transient receptor potential cation channel subfamily C member 3 (TRPC3), a ubiquitously expressed non-selective cation channel protein, controls proliferation, inflammation, and immune response via operating calcium influx in various organs. However, our understanding on the biofunction of hepatic TRPC3 is still limited. The present study aims to clarify the role and potential mechanism(s) of TRPC3 in alcohol-associated liver disease (ALD). We recently found that TRPC3 expression plays an important role in the disease process of ALD. Alcohol exposure led to a significant reduction of hepatic TRPC3 in patients with alcohol-related hepatitis (AH) and ALD models. Antioxidants (N-acetylcysteine and mitoquinone) intervention improved alcohol-induced suppression of TRPC3 via a miR-339-5p-involved mechanism. TRPC3 loss robustly aggravated the alcohol-induced hepatic steatosis and liver injury in mouse liver; this was associated with the suppression of Ca2+/calmodulin-dependent protein kinase kinase 2 (CAMKK2)/AMP-activated protein kinase (AMPK) and dysregulation of genes related to lipid metabolism. TRPC3 loss also enhanced hepatic inflammation and early fibrosis-like change in mice. Replenishing hepatic TRPC3 effectively reversed chronic alcohol-induced detrimental alterations in ALD mice. Briefly, chronic alcohol exposure-induced TRPC3 reduction contributes to the pathological development of ALD via suppression of the CAMKK2/AMPK pathway. Oxidative stress-stimulated miR-339-5p upregulation contributes to alcohol-reduced TRPC3. TRPC3 is the requisite and a potential target to defend alcohol consumption-caused ALD.
Post-Traumatic Osteoarthritis, Psychological Health, and Quality of Life After Lower Limb Injury in U.S. Service Members
Authors: Farrokhi Shawn , Gunterstockman Brittney Mazzone , Hendershot Brad D , Russell Esposito Elizabeth , McCabe Cameron T , Watrous Jessica R 
Published: December 2023

ABSTRACT

Introduction
The aims of this project were to assess (1) the prevalence and timing of post-traumatic osteoarthritis (PTOA) after a traumatic lower limb injury, (2) the risk of PTOA based on injury type, and (3) the association of PTOA with psychological health and quality of life (QoL).

Materials and Methods
The Wounded Warrior Recovery Project (WWRP) database and the Expeditionary Medical Encounters Dataset were queried to identify service members injured during deployment. The Military Health System Data Repository was utilized to extract medical record data to identify individuals with PTOA. Data on PTSD, depression symptoms, and QoL were extracted from the WWRP.

Results
Of the 2,061 WWRP participants with lower limb injuries, 124 (6%) were diagnosed with PTOA, with first PTOA diagnosis occurring 3.8 ± 3.1 years after injury. Of the injury categories identified, only fractures were associated with high odds of lower limb PTOA (adjusted odds ratio [OR] = 3.92, 95% confidence interval [CI]: 2.38, 6.44). Individuals with PTOA diagnoses reported lower QoL scores relative to those without PTOA (F(1,2057) = 14.21, B = −0.05, P &lt; .05). Additionally, rates of PTSD and depression symptoms were high but not different between those with or without PTOA.

Conclusions
Despite a low prevalence of lower limb PTOA in our study, fractures increased the risk of PTOA after deployment-related injuries. Additionally, those with PTOA reported lower QoL scores relative to those without PTOA. The findings of this study highlight the personalized needs of patients with trauma beyond just the repair of the immediate injury.
Analysis of cytosine deamination events in excision repair sequencing reads reveals mechanisms of incision site selection in NER
Authors: Morledge-Hampton Benjamin , Kalyanaraman Ananth , Wyrick John J 
Published: December 2023

Abstract
Nucleotide excision repair (NER) removes helix-distorting DNA lesions and is therefore critical for genome stability. During NER, DNA is unwound on either side of the lesion and excised, but the rules governing incision site selection, particularly in eukaryotic cells, are unclear. Excision repair-sequencing (XR-seq) sequences excised NER fragments, but analysis has been limited because the lesion location is unknown. Here, we exploit accelerated cytosine deamination rates in UV-induced CPD (cyclobutane pyrimidine dimer) lesions to precisely map their locations at C to T mismatches in XR-seq reads, revealing general and species-specific patterns of incision site selection during NER. Our data indicate that the 5′ incision site occurs preferentially in HYV (i.e. not G; C/T; not T) sequence motifs, a pattern that can be explained by sequence preferences of the XPF-ERCC1 endonuclease. In contrast, the 3′ incision site does not show strong sequence preferences, once truncated reads arising from mispriming events are excluded. Instead, the 3′ incision is partially determined by the 5′ incision site distance, indicating that the two incision events are coupled. Finally, our data reveal unique and coupled NER incision patterns at nucleosome boundaries. These findings reveal key principles governing NER incision site selection in eukaryotic cells.
Radiotherapy intensification for atypical and malignant meningiomas: A systematic review
Authors: Gaito Simona , Goyal Love , Rieu Romelie , France Anna , Burnet Neil G , Barker Claire , Pan Shermaine , Colaco Rovel J , Minniti Giuseppe , Roncaroli Federico , Smith Ed , Aznar Marianne , Whitfield Gillian 
Published: December 2023

Abstract

Background
The outcomes of nonbenign (WHO Grades 2 and 3 [G2, G3]) meningiomas are suboptimal and radiotherapy (RT) dose intensification strategies have been investigated. The purpose of this review is to report on clinical practice and outcomes with particular attention to RT doses and techniques.

Methods
The PICO criteria (Population, Intervention, Comparison, and Outcomes) were used to frame the research question, directed at outlining the clinical outcomes in patients with G2−3 meningiomas treated with RT. The same search strategy was run in Embase and MEDLINE and, after deduplication, returned 1 807 records. These were manually screened for relevance and 25 were included.

Results
Tumor outcomes and toxicities are not uniformly reported in the selected studies since different endpoints and time points have been used by different authors. Many risk factors for worse outcomes are described, the most common being suboptimal RT. This includes no or delayed RT, low doses, and older techniques. A positive association between RT dose and progression-free survival (PFS) has been highlighted by analyzing the studies in this review (10/25) that report the same endpoint (5y-PFS).

Conclusions
This literature review has shown that standard practice RT leads to suboptimal tumor control rates in G2–3 meningiomas, with a significant proportion of disease recurring after a relatively short follow-up. Randomized controlled trials are needed in this setting to define the optimal RT approach. Given the increasing data to suggest a benefit of higher RT doses for high-risk meningiomas, novel RT technologies with highly conformal dose distributions are preferential to achieve optimal target coverage and organs at risk sparing.
Exploring the physiological factors relating to energy balance in women with polycystic ovary syndrome: a scoping review
Authors: Nguo Kay , McGowan Margaret , Cowan Stephanie , Davidson Zoe , Pirotta Stephanie , Dordevic Aimee L , Teede Helena , Hajishafiee Maryam , Carmichael Mikaeli , Moran Lisa J 
Published: December 2023

Abstract

Polycystic ovary syndrome (PCOS) occurs in 8%-13% of reproductive-aged women and is associated with reproductive, metabolic, and psychological dysfunction. Overweight and obesity are prevalent and exacerbate the features of PCOS. The aim of this review is to evaluate the extent of evidence examining the physiological factors affecting energy homeostasis, which may impact weight gain, weight loss, and weight maintenance in PCOS, and identify research gaps and recommendations for future research. Literature searches using MEDLINE, EMBASE, PsycInfo, AMED, CINAHL, and Cochrane Central Register of Controlled Trials were conducted up to June 22, 2022. Abstracts, non–English-language articles, and reviews were excluded. A total of n = 78 (n = 55 energy intake and n = 23 energy expenditure) primary research papers were included. Papers with multiple outcomes of interest were counted as separate studies. Energy-intake studies (n = 89) focussed on assessing food, nutrient, or supplements stimuli and were grouped into the outcomes of gastrointestinal appetite hormones (n = 43), adipokines (n = 34), subjective appetite (n = 9), functional brain imaging (n = 3), and neuropeptides (n = 0). Energy-expenditure studies (n = 29) were grouped into total energy expenditure (n = 1), resting energy expenditure (n = 15), meal-induced thermogenesis (n = 3), nutrient oxidation (n = 5), and metabolic flexibility (n = 5). Across both energy-intake and -expenditure papers, 60% of the studies compared outcome responses in women with PCOS with a control group. Results were inconsistent, with 57% reporting no differences and 43% reporting altered responses in PCOS compared with controls, including blunted appetite hormone responses, metabolic inflexibility, and reduced energy expenditure. The authors identified that there is inconsistent, yet preliminary, evidence of possible altered physiological factors, which may impact energy balance and weight management. Further work is needed to act on the identified clinical and research gaps to support women with PCOS and health professionals in informing and achieving realistic weight-management goals for women with PCOS.

Systematic Review Registration
The protocol was prospectively registered on the Open Science Framework on February 16, 2021 (https://osf.io/9jnsm).
Efficacy and Safety of Panitumumab in Patients With RAF/RAS-Wild-Type Glioblastoma: Results From the Drug Rediscovery Protocol
Authors: Spiekman Ilse A C , Geurts Birgit S , Zeverijn Laurien J , de Wit Gijs F , van der Noort Vincent , Roepman Paul , de Leng Wendy W J , Jansen Anne M L , Kusters Benno , Beerepoot Laurens V , de Vos Filip Y F L , de Groot Derk-Jan A , de Groot Jan Willem B , Hoeben Ann , Buter Jan , Gelderblom Hans A J , Voest Emile E , Verheul Henk M W 
Published: December 2023

Abstract

Background
The prognosis of malignant primary high-grade brain tumors, predominantly glioblastomas, is poor despite intensive multimodality treatment options. In more than 50% of patients with glioblastomas, potentially targetable mutations are present, including rearrangements, altered splicing, and/or focal amplifications of epidermal growth factor receptor (EGFR) by signaling through the RAF/RAS pathway. We studied whether treatment with the clinically available anti-EGFR monoclonal antibody panitumumab provides clinical benefit for patients with RAF/RAS-wild-type (wt) glioblastomas in the Drug Rediscovery Protocol (DRUP).

Methods
Patients with progression of treatment refractory RAF/RASwt glioblastoma were included for treatment with panitumumab in DRUP when measurable according to RANO criteria. The primary endpoints of this study are clinical benefit (CB: defined as confirmed objective response [OR] or stable disease [SD] ≥ 16 weeks) and safety. Patients were enrolled using a Simon-like 2-stage model, with 8 patients in stage 1 and up to 24 patients in stage 2 if at least 1 in 8 patients had CB in stage 1.

Results
Between 03-2018 and 02-2022, 24 evaluable patients were treated. CB was observed in 5 patients (21%), including 2 patients with partial response (8.3%) and 3 patients with SD ≥ 16 weeks (12.5%). After median follow-up of 15 months, median progression-free survival and overall survival were 1.7 months (95% CI 1.6-2.1 months) and 4.5 months (95% CI 2.9-8.6 months), respectively. No unexpected toxicities were observed.

Conclusions
Panitumumab treatment provides limited CB in patients with recurrent RAF/RASwt glioblastoma precluding further development of this therapeutic strategy.
Domestic Violence, Religion, and Migration
Authors: Istratii Romina 
Published: December 2023

Abstract
The effects of religious beliefs in the domestic violence experience of migrant communities has been increasingly documented in recent years. The current chapter aims to delineate the nuanced relationship between domestic violence, faith, and migration by discussing the available evidence and extracting key implications on appropriate faith-sensitive interventions. It proceeds with a decolonial reflexivity, recognizing that most research on domestic violence and religion emanated historically from Western societies, specifically the United States and Canada, and has been guided primarily by Anglo-American definitions and theorizations of religion and domestic violence, which can be limiting or inappropriate in non-Western tradition-oriented religious societies and their international diaspora and migrant communities. The need to embed religious belief systems in the cultural contexts of their historical development multi-dimensionally and to move toward more transboundary, culturally embedded, multilingually aware, and theologically informed approaches is stressed as a means to researching domestic violence and designing faith-sensitive interventions cross-culturally.
Dance in Calendrical Community Celebrations in Romania
Authors: Mellish Liz 
Published: December 2023

Abstract
Romania has a vast array of calendrical celebrations, customs, rituals, and festivals that can be divided into fixed date and variable date celebrations linked to the ecclesiastical calendar, the seasonal work cycle (including the interaction of the pastoral, agrarian, and viticulture calendars), or are annual secular commemorations of a particular person, group of people, or event. This chapter focuses on community calendrical celebrations that include dancing, both those that have a long history and those that have been inserted into the annual calendar more recently. These celebrations take place in all areas of Romania, in both villages and urban areas, and can include both participatory and presentational dances that form part of the overall event. These celebrations have retained their position in the annual calendar for many decades or centuries, although the details of each event have evolved over time, influenced by both internal and external factors.
Muslim Women’s Religious and Social Activism in Western Europe
Authors: Jouili Jeanette S. 
Published: December 2023

Abstract
This chapter charts the development of Muslim women’s activism in Europe from the 1970s to today. It describes in particular four domains of activism Muslim women tended to be involved in: first, activism concerned with empowering women within Muslim communities and within the broader societies; second, religious activism within Islamic communities and institutions; third, struggles around recognition and religious minority rights; and fourth, activism on other social and political issues. What emerges from this overview is that Muslim women’s activism in Europe (as elsewhere) circumscribes an extremely diverse field, with a number of different, even incommensurable concerns and agendas. These concerns and agendas are shaped in various ways by the particular socioeconomic conditions in which these women live and are often a response to the political discourses constructed about them in their respective societies.
The Qur’ān and Woman
Authors: Abugideiri Hibba 
Published: December 2023

Abstract
This chapter offers a fresh perspective on three of the most prominent female figures in the Qur’ān: Mary, Bilqīs, and Zulaykha. The signification of these women is reinterpreted through a proposed hermeneutic of seeing and unseeing gender that, on the one hand, reveals how woman and man play ontologically contingent and correlative parts in each of the three Qur’ānic stories, yet on the other hand, also upholds transcendental lessons of an undifferentiated spirituality. Situated within a broader God–human relationship that recovers notions of divine immanence and not just transcendence, this scriptural reading offers an alternative understanding of woman that challenges problematic interpretations by classical and medieval Qur’anic commentators.
Women’s Religious and Social Activism in Palestine, Lebanon, and Syria
Authors: Brownson Elizabeth 
Published: December 2023

Abstract
In the scholarship on women’s Islamist and Islamic activism in Palestine, Lebanon, and Syria, women’s empowerment and agency are recurring themes, however, conceptions of empowerment are contested. Studies range from cautiously asserting that Muslim women’s activism could potentially be empowering to demonstrating that it is in fact empowering. Another major debate concerns the relationship between Islamists and secular feminists, and whether Islamists’ versions of Islam are compatible with women’s rights. Some scholars describe Islamist and feminist convictions as posing an unbridgeable gap, while others show that dialogue has occurred in the past and suggest further common ground is possible. This chapter first examines studies on women’s Islamic activism that describe different degrees of women’s empowerment in Palestine and Lebanon, then it explores the debate on Islamist versus secular activists in Palestine. Finally, it analyzes research on female mosque instructors in Syria and Palestine through the lens of women’s empowerment.