bluuebunny/crossref_metadata_2025_split huggingface dataset:
FEM modelling of hydrogen embrittlement in API 5L X65 steel for safe hydrogen transportation
Authors: Nazar Shaghayegh , Lipiec Sebastian , Proverbio Edoardo 
Published: February 2025

Abstract
Hydrogen is crucial for decarbonization efforts due to its abundance, environmental friendliness, and versatility. To maximize its potential, an efficient transportation infrastructure is essential. While utilizing the natural gas pipeline network for transporting hydrogen is cost-effective, hydrogen embrittlement (HE) poses a significant challenge. When hydrogen enters the metal, it significantly compromises its fracture toughness. This study investigates the impact of high-pressure hydrogen on the mechanical properties of API 5L X65 carbon steel through a combined experimental and computational approach. To quantify the extent of HE, tensile tests were performed on identical specimens, one set pre-exposed to high-pressure hydrogen and another set kept in an inert environment for comparison. Finite element modelling, employing the Bai-Wierzbicki material model (BWMM), was used to simulate the material behaviour under large plastic deformations and correlate with experimental results. This synergistic approach integrates experimental data with simulations, creating a framework for predicting and preventing catastrophic failures.
Consumer negative opinions on stock returns: evidence from E-commerce reviews in China
Authors: Wu Danni , Zhou Zhenkun , Su Zhi 
Published: February 2025

Abstract
This study investigates the significance of e-commerce consumer opinions regarding value in China’s A-share market. By analyzing a large dataset comprising over 18 million online consumer reviews on JD.com, we demonstrate that sentiments expressed in e-commerce reviews can influence stock returns. This indicates that consumer opinions on the e-commerce platform contain valuable information that can impact the stock market. Our findings show that Consumer Negative Sentiment Tendency (CNST) and One-Star Tendency (OST) have a negative effect on expected stock returns, even after controlling for firm characteristics such as market risk, illiquidity, idiosyncratic volatility, and asset growth. Further analysis indicates that CNST demonstrates stronger predictive power within the home appliance industry, under high sentiment conditions, in growth companies, and among firms with lower accounting transparency. We also find that CNST negatively predicts revenue surprises, earnings surprises, and cash flow shocks. These results suggest that consumer opinions and sentiments derived from e-commerce reviews highlight firms’ intrinsic worth and prospects. Future research could explore how firms, including suppliers and logistics companies, can leverage the information conveyed by consumer opinions on e-commerce platforms.
When LLMs meet cybersecurity: a systematic literature review
Authors: Zhang Jie , Bu Haoyu , Wen Hui , Liu Yongji , Fei Haiqiang , Xi Rongrong , Li Lun , Yang Yun , Zhu Hongsong , Meng Dan 
Published: February 2025

Abstract
The rapid development of large language models (LLMs) has opened new avenues across various fields, including cybersecurity, which faces an evolving threat landscape and demand for innovative technologies. Despite initial explorations into the application of LLMs in cybersecurity, there is a lack of a comprehensive overview of this research area. This paper addresses this gap by providing a systematic literature review, covering the analysis of over 300 works, encompassing 25 LLMs and more than 10 downstream scenarios. Our comprehensive overview addresses three key research questions: the construction of cybersecurity-oriented LLMs, the application of LLMs to various cybersecurity tasks, the challenges and further research in this area. This study aims to shed light on the extensive potential of LLMs in enhancing cybersecurity practices and serve as a valuable resource for applying LLMs in this field. We also maintain and regularly update a list of practical guides on LLMs for cybersecurity at https://github.com/tmylla/Awesome-LLM4Cybersecurity.
Savoring the past, preserving the future: a mixed-methods examination of culinary traditions among Pontic Greeks in Northern Greece
Authors: Keramaris Achillefs , Kasapidou Eleni , Mitlianga Paraskevi 
Published: February 2025

Abstract
This mixed-methods study investigates how Pontic Greeks in Western Macedonia, Greece, preserve and adapt their culinary traditions amid modern challenges. Employing survey questionnaires (n = 390), interviews, and participant observation, we explored sociodemographic attributes, lifestyle factors, and food preferences. Statistical and thematic analyses revealed a strong preference for traditional delicacies, such as pisia (a type of pancake) and tanomenon sorva (yogurt soup), alongside a notable shift from butter to olive oil driven by health considerations. Qualitative findings underscored the deep cultural and emotional significance of these foods, revealing themes such as intergenerational knowledge transmission, urbanization’s impact, and the dual role of heritage and convenience in shaping food choices. Integrated data analysis revealed a convergence regarding the importance of preserving culinary traditions in the face of societal change, illustrating the dynamic nature of Pontic Greek gastronomy. This study demonstrates how personal, cultural, environmental, and societal factors influence the maintenance and evolution of these culinary practices.
Carvacrol attenuated haloperidol-induced Parkinson’s disease via TNF/NFκβ-NLRP3-mediated pyroptosis
Authors: Albaqami Faisal , Ahmad Khawaja Waqas , Shah Fawad Ali 
Published: February 2025

Abstract

Background
Parkinson’s disease is a debilitating and the second most common neurodegenerative disorder with a high prevalence. Parkinson’s disease has a multifaceted etiology characterized by an altered redox state and an excessive inflammatory response. In this study, we investigated the potential neuroprotective properties of carvacrol in a haloperidol-induced Parkinson’s model. In female Sprague-Dawley rats, the animal Parkinson model was induced by intraperitoneally administering 1 mg / kg of haloperidol once daily for fifteen days. Carvacrol was administered at a dose of 25 and 50 mg / kg once daily for fifteen days before haloperidol administration. In order to further illustrate the vital role of the tumor necrosis factor (TNF-α) pathway, we administered 50 mg / kg of the TNF-α inhibitor thalidomide once daily for 15 days.

Results
Our results showed that haloperidol-induced motor deficits, changed endogenous antioxidant enzymes, along with higher levels of inflammasome (NLRP3) and other inflammatory mediators. Moreover, increased levels of lipid peroxidase (LPO) indicated a significant rise in oxidative stress due to haloperidol. Moreover, carvacrol reduced these effects by preventing pyroptosis mediated by the inflammasome (NLRP3) and TNF-α. The administration of thalidomide mitigated oxidative stress and suppresses inflammatory pathways through the augmentation of the intrinsic antioxidant system. Further, co-treatment of carvacrol with thalidomide synergized the neuroprotective effect of carvacrol as demonstrated by various immunoassays and histology analyses.

Conclusions
Taken together, our findings suggest that carvacrol mitigated haloperidol-induced Parkinson-like symptoms, partially through the downregulation of TNF-α and NLRP3.
Using positive deviance to enhance HIV care retention in South Africa: development of a compassion-focused program to improve the staff and patient experience
Authors: Ober Allison J. , Skinner Donald H. , Bogart Laura M. , Busakwe Leletu , Davids Wadene , Mahomed Hassan , Ling Debbie , Zweigenthal Virginia 
Published: February 2025

Abstract

Background
HIV burden remains high in South Africa despite intensive efforts to curtail the epidemic. Public primary care facilities, where most people with HIV (PWH) in South Africa receive treatment, face myriad challenges retaining patients on antiretroviral therapy (ART). Nevertheless, some facilities manage to consistently retain PWH in care. We used a participatory positive deviance (PD) approach to discover characteristics of primary care facilities with above-average 12-month retention rates to develop an intervention.

Methods
We conducted 11 in-depth leadership interviews, 9 staff focus groups with 29 participants, 11 patient focus groups with 45 participants, 23 patient shadowing visits, and multiple facility observations in each of 3 high- and 3 low-retention public primary care facilities in Cape Town, South Africa. Using PD, an asset-based approach to behavior change that consists of discovering how high-performing outliers succeed despite sizable barriers, and then using those data to develop interventions for low performers, we analyzed data to discover dominant characteristics of higher-retention facilities that might be contributing to higher retention rates.

Results
Dominant themes found in higher-retention facilities were compassionate, respectful, and patient-centered care; higher staff morale, passion for the work, and team cohesion; efficient workflow procedures; and a welcoming physical environment. From these themes, we developed the multidimensional Connect intervention, consisting of strategies within three domains: (1) engage, encourage, and support staff (e.g., a monthly staff support huddle, a compassion training); (2) expedite and augment workflow procedures (e.g., adjust folder system to lower wait times); and (3) create a welcoming physical environment (e.g., fresh paint and plants in the waiting area).

Conclusions
A PD approach enabled us to identify factors that could be contributing to higher ART retention rates within low-resource public sector primary care facilities in Cape Town, South Africa, and to develop a multidimensional intervention. If effective after a future trial, the intervention could be a feasible, affordable complement to existing programs aimed at improving care for PWH.
Respiratory disease in people with major depressive disorder: A systematic review and Meta-analysis
Authors: Jiménez-Peinado Ana , Laguna-Muñoz David , Jaén-Moreno María José , Camacho-Rodríguez Cristina , del Pozo Gloria Isabel , Vieta Eduard , Caballero-Villarraso Javier , Rico-Villademoros Fernando , Sarramea Fernando 
Published: February 2025

Abstract

Background
Living with major depressive disorder (MDD) reduces life expectancy, with respiratory disease being a significant threat. However, evidence on respiratory disease in this population has not yet been meta-analyzed.

Methods
This meta-analysis examines respiratory disease prevalence and odds ratio (OR) in patients with MDD and treatment resistant depression (TRD). A systematic literature search was conducted, with a snowball search of reference and citation lists. Inclusion criteria covered studies in MDD and TRD patients with confirmed diagnoses of respiratory diseases (asthma, chronic obstructive pulmonary disease [COPD], pneumonia, lung cancer, and tuberculosis), comparing with a control group when possible.

Results
From 4,138 retrieved articles, 15 (including 476,927 individuals with MDD, 50,680 with TRD, and 1,108,979 control group) met the inclusion criteria. In MDD patients, COPD prevalence was 9.0% (95% CI: 3.8–19.6%), asthma 8.6% (95% CI: 5.7–12.8%), and pneumonia 2.5% (95% CI: 2.2–2.9%). In TRD patients, COPD prevalence was 9.9% (95% CI: 4.2–21.9%) and asthma 10.9% (95% CI: 10.7–11.2%), but meta-analysis limited to those diseases showed no significant relative risk differences. Compared to the general population, individuals with MDD had significantly higher rates of COPD (OR 1.79, 95% CI: 1.49–2.16), even higher in younger populations (1.85 [95% CI: 1.74–1.97]) and more prevalent in women.

Conclusions
This first meta-analysis on this topic shows that MDD is associated with an increased risk of respiratory illness compared to the general population. The prevalence of asthma doubles the mean described in the general population worldwide, and in COPD, women and younger people are at particular risk. Prevention policies are urgently needed.
Advancements in Interoperability: Achieving Anatomic Pathology Reports That Adhere to International Standards and Are Both Human-Readable and Readily Computable
Authors: Campbell Walter S. , Rous Brian A. , Dubois Stefan , Seegers Paul A. , Dash Rajesh C. , Rüdiger Thomas , Santamaria Suzanne , Wooler Elaine , Case James , Igali Lazslo , Edgerton Mary E. , Simpson Ross W. , Bazyleva Ekaterina , Birdsong George , Moldwin Richard , Helliwell Timothy R. , Yu Peter Paul , Srigley John 
Published: February 2025

PURPOSE
Over the past 50 years, multiple pathology organizations worldwide have evolved in cancer histopathology reporting from subjective, narrative assessments to structured, synoptic formats using controlled vocabulary. These reporting protocols include the required data elements that represent the minimum set of evidence-based, clinically actionable parameters necessary to convey the diagnostic, prognostic, and predictive information essential for patient care. Despite these advances, the synoptic reporting protocols were not harmonized across the various pathology organizations. Cancer pathology continues to be widely reported and stored in free-text format, or without encoded data such that it is neither computable nor interoperable across organizations.

METHODS
In 2020, SNOMED International created the Cancer Synoptic Reporting Working Group (CSRWG). This resulted in international collaboration across multiple pathology organizations. CCRWG's mission was to use SNOMED Clinical Terms (CT) concepts to represent the required content within the College of American Pathologists (CAP) and International Collaboration on Cancer Reporting (ICCR) published pathology reporting protocols.

RESULTS
In late 2023, the CSRWG published over 1,300 new or revised SNOMED CT concepts to represent all required pathology cancer data elements for adult and pediatric solid tumors in both CAP and ICCR using the semantic principles of the SNOMED-CT concept model. Thus, computability and interoperability would be broadly established.

CONCLUSION
This work brings to fruition the longstanding desire for an international, interoperable, human- and machine-readable cancer pathology report for use in patient care, health care quality improvement, population health, public health surveillance, and translational and clinical trial research. The following report describes the project, its methods, and applications in the stated use cases.
Clinical Course of COVID-19 in Children With Adrenal Insufficiency: Results From National Data
Authors: Capalbo Donatella , Moracas Cristina , Guazzarotti Laura , Baronio Federico , Stancampiano Marianna Rita , Ortolano Rita , Valenzise Mariella , Bizzarri Carla , Patti Giuseppa , Longhi Silvia , Giavoli Claudia , Guzzetti Chiara , Zoletto Silvia , Lattanzio Crescenza , Cavarzere Paolo , Street Maria Elisabeth , Faienza Maria Felicia , Grandone Anna , Cappa Marco , Wasniewska Malgorzata Gabriela , Russo Gianni , Maghnie Mohamad , Salerno Mariacarolina 
Published: February 2025

Abstract

Context
There has been concern about a potential increase in the incidence or severity of coronavirus disease 2019 (COVID-19) in individuals with adrenal insufficiency (AI). Data on the course of SARS-CoV-2 infection in AI children are lacking.

Objective
Evaluate whether children with AI are more susceptible to the infection or are at risk of severe COVID-19.

Methods
In this multicenter, retrospective study among 1143 children with AI, 148 contracted SARS-CoV-2 (112 with primary, 36 with secondary AI) and were evaluated for severity and outcomes of infection, along with 74 control subjects with normal adrenal function.

Results
The prevalence of COVID-19 in the AI cohort was 12.9%, not increased compared to pediatric Italian population in the same period. The severity was not increased in AI subjects and was classified as follows in patients vs controls: asymptomatic in 14.9% vs 10.8%; paucisymptomatic in 33.8% vs 37.8%; mild in 45.3% vs 45.9%; severe in 3.4% vs 2.7%; critical in 2.7% vs 2.7%. Among those with severe COVID, 4 patients with AI (2.7%) and 3 controls (4%) developed pneumonia while 3 patients with PAI (2%) and 2 controls (2.7%) developed multisystem inflammatory syndrome (P not statistically significant). Only 5 patients (3.4%) experienced an adrenal crisis during a severe COVID-19. The hospitalization rate was the same in patients vs controls (9.5%). All subjects completely recovered, and no COVID-related deaths were documented.

Conclusion
Our findings do not indicate that AI is associated with increased susceptibility to SARS-CoV-2 infection or higher risk for severe COVID-19 in children.
Central and Peripheral Roles of Salt-inducible Kinases in Metabolic Regulation
Authors: Onda Danise-Ann , Zhu Yifei , Yuan XiaoZhuo , Loh Kim 
Published: February 2025

Abstract
Salt-inducible kinases (SIKs), a member of the serine/threonine protein kinase family, have recently garnered considerable research interest as one of the emerging key regulators of metabolism. The 3 SIK isoforms—SIK1, SIK2, and SIK3—exhibit diverse roles both in central and peripheral physiological processes. While early studies focused on their role in inflammation, spurring the development of SIK inhibitors for chronic inflammatory diseases currently in clinical trials, emerging evidence highlights their broader functions in metabolism. In this review, we will summarize the current state of research on the central roles of SIKs in the brain, particularly in regulating energy balance and glucose homeostasis, alongside their peripheral functions in critical metabolic tissues such as the liver, adipose tissue, and pancreas. By integrating insights into their central and peripheral roles, this review underscores the importance of SIKs in maintaining metabolic homeostasis and highlights their therapeutic potential as novel targets for metabolic disease.
The Aesthetics of Resistance, Volume III
Authors: Weiss Peter 
Published: February 2025

A major literary event, the publication of the final volume of Peter Weiss’s three-volume novel The Aesthetics of Resistance makes one of the towering works of twentieth-century German literature available to English-speaking readers for the first time. Weiss’s crowning achievement, The Aesthetics of Resistance spans the period from the late 1930s to the end of World War II, dramatizing antifascist resistance and the rise and fall of proletarian political parties in Europe.
Volume III, initially published in 1981, teems with characters, many of whom are based on historical figures. It commences in May of 1940, as the narrator’s parents flee Nazi forces in Eastern Europe and reunite with their son in Sweden. While in Stockholm, the narrator and other Communist activists living in exile struggle to build structures in the German underground. The story then follows Communist resistance fighter Charlotte Bischoff as she is smuggled to Bremen on a freighter. In Berlin, she contacts the narrator’s friends and joins the Red Orchestra resistance group. Soon, the Gestapo cracks the underground group’s code, arrests a number of its members, and takes them to Plötzensee Prison, where most of them are executed. Featuring the narrator’s meditations on paintings, sculpture, and literature throughout, The Aesthetics of Resistance demonstrates the affinity between political resistance and art. Ultimately, Weiss argues that we must look to art for new models of political action and social understanding.
Surgical Adverse Events for Primary Tumors of the Spine and Their Impact on Outcomes: An Observational Study From the Primary Tumors Research and Outcomes Network
Authors: Laflamme Mathieu , Gasbarrini Alessandro , Rhines Laurence D. , Lazary Aron , Gokaslan Ziya L. , Reynolds Jeremy J. , Luzzati Alessandro , Disch Alexander C. , Chou Dean , Clarke Michelle J. , Wei Feng , Bettegowda Chetan , Rampersaud Y. Raja , Boriani Stefano , Shin John H. , Lord Elizabeth , Sciubba Daniel M. , Laufer Ilya , Sahgal Arjun , Fisher Charles G. , Dea Nicolas ,   on behalf of the AO Spine Knowledge Forum Tumor
Published: February 2025

BACKGROUND AND OBJECTIVES:
Aggressive resection for primary tumors of the spine are associated with a high rate of adverse events (AEs), but the impact of AEs on patient-reported outcomes (PROs) remains unknown and is critical to the shared decision-making. Our primary objective was to assess the impact of surgical AEs on PROs using an international registry. Assessing the impact on clinical outcomes and identifying risk factors for AEs were our secondary objectives.

METHODS:
Patients who underwent surgery for a primary spinal tumor were selected through the Primary Tumor Research and Outcomes Network. Our primary outcome was the impact of AEs on PROs at 3 and 12 months after surgery (measured with Spinal Oncology Study Group Outcomes Questionnaire, Short-Form 36, and EuroQol 5 Dimension). We also assessed the impact on clinical outcomes (local control, surgical margins, readmission, reoperation, and mortality). We stratified our results according to severity of AEs, histology, and type of resection.

RESULTS:
374 patients met inclusion criteria (219 males/155 females). The mean age of the cohort was 48.7 years. The most frequent histology was chordoma (37.3%) followed by chondrosarcoma (8.8%). Sixty-seven patients (17.9%) experienced at least 1 intraoperative AE and 117 patients (31.3%) had at least 1 postoperative AE within 3 months. Overall, 159 patients (42.5%) experienced AEs. The readmission rate was significantly higher in patients who experienced AEs (Any AE: 10.1% vs no AE: 1.9% within 3 months; P = <0.001). PROs were not significantly affected by AEs in most questionnaires. Local control, risk of reoperation, mortality, and achieving preplanned margins were similar between AE groups.

CONCLUSION:
The rate of surgical AEs is considerable in this population. Surgical AEs seem to be associated with a higher number of readmissions, but do not seem to result in significant differences in PROs or in a higher risk of reoperation, mortality, and failure to achieve preplanned margins.
Amyloid-β can activate JNK signalling via WNT5A-ROR2 to reduce synapse formation in Alzheimer's disease
Authors: Fang Kevin , Pishva Ehsan , Piers Thomas , Scholpp Steffen 
Published: February 2025

ABSTRACT
Wnt signalling is an essential signalling system in neurogenesis, with a crucial role in synaptic plasticity and neuronal survival, processes that are disrupted in Alzheimer's disease (AD). Within this network, the Wnt/β-catenin pathway has been studied for its neuroprotective role, and this is suppressed in AD. However, the involvement of the non-canonical Wnt-planar cell polarity (Wnt/PCP) pathway in AD remains to be determined.
This study investigates the role of ROR2, a Wnt/PCP co-receptor, in synaptogenesis. We demonstrate that WNT5A-ROR2 signalling activates the JNK pathway, leading to synapse loss in mature neurons. This effect mirrors the synaptotoxic actions of Aβ1-42 and DKK1, which are elevated in AD. Notably, blocking ROR2 and JNK mitigates Aβ1-42 and DKK1-induced synapse loss, suggesting their dependence on ROR2. In induced pluripotent stem cell (iPSC)-derived cortical neurons carrying a PSEN1 mutation, known to increase the Aβ42/40 ratio, we observed increased WNT5A-ROR2 clustering and reduced numbers of synapses. Inhibiting ROR2 or JNK partially rescued synaptogenesis in these neurons. These findings suggest that, unlike the Wnt/β-catenin pathway, the Wnt/PCP-ROR2 signalling pathway can operate in a feedback loop with Aβ1-42 to enhance JNK signalling and contribute to synapse loss in AD.