bluuebunny/crossref_metadata_2025_split huggingface dataset:
Preferences for and intention to use an app for premenstrual mental health symptoms using the Health Behaviour Model (HBM)
Authors: Funnell Erin L. , Martin-Key Nayra A. , Benacek Jiri , Spadaro Benedetta , Bahn Sabine 
Published: November 2023

Abstract
Premenstrual symptoms are common, with premenstrual syndrome and premenstrual dysphoric disorder associated with decreased wellbeing and suicidality. High-quality apps can offer convenient support for premenstrual mental health symptoms. We aimed to understand app preferences and Health Belief Model (HBM) constructs driving app use intention. A online survey was delivered. Structural equation modelling (SEM) explored HBM constructs. Data from 530 participants were analysed. Symptom monitoring (74.72%, n = 396) and psychoeducation (57.92%, n = 307) were sought after, with 52.64% (n = 279) indicating unwillingness to pay. Satorra Bentler-scaled fit statistics indicated a good model fit (χ2(254) = 565.91, p < .001; CFI = .939, RMSEA = .048, SRMR = .058). HBM constructs explained 58.22% of intention to use, driven by cues to action (β = .49, p < .001), perceived barriers (β=-.22, p < .001), perceived severity (β = .16, P = .012), and perceived benefits (β = .10, p = .035). Results indicate that app developers should engage in co-design, secure endorsement from healthcare professionals, highlight therapeutic benefits, and address barriers like digital discomfort, privacy concerns, and quality.
Nomogram that can predict failure of conservative treatment for thoracolumbar burst fracture was established
Authors: sun lele , shi lei , WANG kangkang , CAO Jie , Yin wen , LIANG Chengmin 
Published: November 2023

Abstract
Objective: This research aimed to identify risk factors for the failure of conservative treatment for thoracolumbar burst fracture (TBF) and develop a nomogram to predict it.
Methods: A total of 152 patients with TBF who underwent conservative treatment were evaluated, including successfully-received-conservative-treatment (SRCT) group (120 cases) and converted-to-surgical-treatment (CST) group (32 cases), in our medical center from December 2016, to December 2022. The risk factors for CST were identified using univariate and multivariate logistic regression analyses. Then, a nomogram was created and evaluated using the bootstrap method. The discrimination, calibration, and clinical value of the nomogram were assessed using the receiver operating characteristic curve (ROC), a calibration curve, a clinical impact curve (CIC), and decision curve analysis (DCA).
Results: Age, smoking, interpedicular distance, canal compromise, and local kyphotic angles were regarded as independent risk variables for CST (p < 0.05). The area under the ROC was 0.87 (0.79–0.94). The calibration curve and the ideal curve were fitted using the bootstrap method, which was internally repeated 1000 times. The average absolute error was 0.04, and the projected values were in good agreement with the actual values. DCA demonstrated a high risk threshold range (0.10–0.86). CIC showed that the nomogram exhibited clinical applicability, and it may be utilized to predict the high-risk population at various levels.
Conclusions: Age, smoking, interpedicular distance, canal compromise, and local kyphosis angle are independent risk factors for CST. The nomogram established in this study, with high sensitivity and specificity, may effectively predict CST risk.
A Novel 3D Geometry-Based Propagation Model for RIS-Aided Macrocell High-Speed Railway Communication Environments
Authors: Zhou Beiping , Zhao Keqi , Zhao Yongfeng , Abulihaiti Yierfan , Yang Chen , Fu Linghan 
Published: November 2023

Abstract
Reconfigurable intelligence surface (RIS) consists of a large number of low-cost passive reflecting elements has attracted significant attention from communication communities, which is mainly due to its ability to substantially improve the communication performance. In light of this, we develop a three-dimensional (3D) geometry-based multiple-input multiple-output (MIMO) propagation model in this article, which is mainly suitable for describing the high-speed railway communications assisted by RIS in macrocell environments, such as train-to-train scenarios. In such propagation model, the waves emitted from the mobile transmitter experience non line of sight (NLoS) propagation links before reaching the mobile receiver, as well as the RIS propagation links before reaching the receiver. We compute the expressions of the RIS-assisted high-speed railway channel propagation properties, for example, spatial-time (ST) cross-correlation functions (CCFs), between different propagation links. Then, we study the temporal auto-correlation functions (ACFs) of the propagation links in the provided propagation model for distinct movement time instants. Analysis shows that the communication performance can be enhanced by rising the number and the size of RIS reflecting elements, and it is validated by numerical simulation results.
Biological Significance of EphB4 Expression in Cancer
Authors: Ullah Asmat , Razzaq Anam , Zhou Chuanzan , Ullah Najeeb , Shehzadi Somia , Aziz Tariq , Alfaifi Mohammad Y. , Elbehairi Serag Eldin I. , Iqbal Haroon 
Published: November 2023

Abstract:
Eph receptors and their Eph receptor-interacting (ephrin) ligands comprise a vital cell
communication system with several functions. In cancer cells, there was evidence of bilateral Eph
receptor signaling with both tumor-suppressing and tumor-promoting actions. As a member of the
Eph receptor family, EphB4 has been linked to tumor angiogenesis, growth, and metastasis, which
makes it a viable and desirable target for drug development in therapeutic applications. Many investigations
have been conducted over the last decade to elucidate the structure and function of
EphB4 in association with its ligand ephrinB2 for its involvement in tumorigenesis. Although several
EphB4-targeting drugs have been investigated, and some selective inhibitors have been evaluated
in clinical trials. This article addresses the structure and function of the EphB4 receptor, analyses
its possibility as an anticancer therapeutic target, and summarises knowledge of EphB4 kinase
inhibitors. To summarise, EphB4 is a difficult but potential treatment option for cancers.
Supersaturation Behavior: Investigation of Polymers Impact on Nucleation
Kinetic Profile for Rationalizing the Polymeric Precipitation Inhibitors
Authors: Handa Uditi , Malik Anuj , Guarve Kumar , Rani Nidhi , Sharma Prerna 
Published: November 2023

Background:
Although nucleation kinetic data is quite important for the concept of supersaturation
behavior, its part in rationalizing the crystallization inhibitor has not been well understood.

Objective:
This study aimed to investigate the nucleation kinetic profile of Dextromethorphan HBr
(as an ideal drug, BCS-II) by measuring liquid-liquid phase segregation, nucleation induction time,
and Metastable Zone width.

Methods:
Surfeit action was examined by a superfluity assay of the drug. The concentration was
scrutinized by light scattering techniques (UV spectrum (novel method) and Fluorometer (CL 53)).

Results:
The drug induction time was 20 min without polymer and 90 and 110 min with polymers,
such as HPMC K15M and Xanthan Gum, respectively. Therefore, the order of the polymer's ability
to inhibit nucleation was Xanthan Gum > HPMC K15M in the medium (7.4 pH). Similarly, the drug
induction time was 30 min without polymer and 20, 110, and 90 min with polymers, such as Sodium
CMC, HPMC K15M, and Xanthan Gum, respectively. Therefore, the order of the polymer's ability
to inhibit nucleation was HPMC K15M > Xanthan Gum > Sodium CMC in SIFsp (6.8 pH), which
synchronizes the polymer’s potentiality to interdict the drug precipitation.

Conclusion:
The HPMC K15M and xanthan Gum showed the best crystallization inhibitor effect for
the maintenance of superfluity conditions till the drug absorption time. The xanthan gum is based on
the “glider” concept, and this shows the novelty of this preliminary research. The screening methodology
used for rationalizing the best polymers used in the superfluity formulations development successfully.
Antibiotic Potentiation Through Phytochemical-Based Efflux Pump
Inhibitors to Combat Multidrug Resistance Bacteria
Authors: Cheema Harveer Singh , Maurya Anupam , Kumar Sandeep , Pandey Vineet Kumar , Singh Raman Mohan 
Published: November 2023

Background:
Antimicrobial resistance development poses a significant danger to the
efficacy of antibiotics, which were once believed to be the most efficient method for treating infections
caused by bacteria. Antimicrobial resistance typically involves various mechanisms, such as
drug inactivation or modification, drug target modification, drug uptake restriction, and drug efflux,
resulting in decreased antibiotic concentrations within the cell. Antimicrobial resistance has been
associated with efflux Pumps, known for their capacity to expel different antibiotics from the cell
non-specifically. This makes EPs fascinating targets for creating drugs to combat antimicrobial
resistance (AMR). The varied structures of secondary metabolites (phytomolecules) found in plants
have positioned them as a promising reservoir of efflux pump inhibitors. These inhibitors act as
modifiers of bacterial resistance and facilitate the reintroduction of antibiotics that have lost clinical
effectiveness. Additionally, they may play a role in preventing the emergence of multidrug resistant
strains.

Objective:
The objective of this review article is to discuss the latest studies on plant-based efflux
pump inhibitors such as terpenoids, alkaloids, flavonoids, glycosides, and tetralones. It highlighted
their potential in enhancing the effectiveness of antibiotics and combating the development of multidrug
resistance.

Results:
Efflux pump inhibitors (EPIs) derived from botanical sources, including compounds like
lysergol, chanaoclavine, niazrin, 4-hydroxy-α-tetralone, ursolic acid, phytol, etc., as well as their
partially synthesized forms, have shown significant potential as practical therapeutic approaches in
addressing antimicrobial resistance caused by efflux pumps. Further, several phyto-molecules and
their analogs demonstrated superior potential for reversing drug resistance, surpassing established
agents like reserpine, niaziridin, etc.

Conclusion:
This review found that while the phyto-molecules and their derivatives did not possess
notable antimicrobial activity, their combination with established antibiotics significantly reduced
their minimum inhibitory concentration (MIC). Specific molecules, such as chanaoclavine and
niaziridin, exhibited noteworthy potential in reversing the effectiveness of drugs, resulting in a
reduction of the MIC of tetracycline by up to 16 times against the tested strain of bacteria. These
molecules inhibited the efflux pumps responsible for drug resistance and displayed a stronger affinity
for membrane proteins. By employing powerful EPIs, these molecules can selectively target and
obstruct drug efflux pumps. This targeted approach can significantly augment the strength and efficacy
of older antibiotics against various drug resistant bacteria, given that active drug efflux poses a
susceptibility for nearly all antibiotics.
Ranking and Prioritizing Risk Factors for Gastric Cancer
Authors: Yusefi Ali Reza , Bordbar Shima , Mehralian Gholamhossein , Lankarani Kamran Bagheri , Khammarnia Mohammad , Kavosi Zahra , Bastani Peivand 
Published: November 2023

Background:
Gastric cancer is one of the gastrointestinal tract cancers with the highest mortality rate; hence, accurate knowledge of the main causes of this disease is of paramount importance to plan, monitor, and evaluate national and regional programs to control this cancer. The present study was to rank and prioritize gastric cancer risk factors.

Methods:
In this study, gastric cancer risk factors were first extracted in a systematic review, and they were then ranked and prioritized using a focused group discussion. MICMAC software was used to rank the factors.

Results:
According to the findings, the following 13 factors had the highest effect on the incidence of gastric cancer: socioeconomic status, age, consumption of pickles and sour vegetables, salt consumption, meat consumption (red, smoked, and processed and salty), consumption of fried foods, consumption of fats and oils, consumption of fish (Salty, smoked, and processed), consumption of bread and leftovers and moldy foods, irregular eating habits, excessive daily calorie intake, smoking (cigarettes, opium, and hookah), and alcohol consumption.

Conclusion:
Prioritizing risk factors would help policymakers identify and present executive strategies and detect action priorities to manage gastric cancer risk factors. According to the findings of the present study, national planning to support vulnerable socio-economic groups, the development of screening programs, and the early detection of diseases in the early stages at an early age, and diet adjustment to increase the consumption of fresh fruits and vegetables and reduce salt, high-fat and fried foods, salted foods, and processed meats are recommended.
Linear and Nonlinear Associations between Meteorological Variables and the Incidence of Malaria in Zahedan District Southwest of Iran 2000-2019
Authors: Nili Sairan , Khanjani Narges , Ghaderi Ebrahim , Mohammadkhani Minoo 
Published: November 2023

Introduction:
Iran is one of the malaria-prone countries. Malaria transmission is likely to be affected by many factors, including meteorological variables. This study aimed to evaluate the effect of climate variables on malaria incidence.

Methods:
A secondary analysis was conducted to examine the relation between malaria and meteorological variables in Zahedan district from 2000 to 2019. We built univariate and multivariate Seasonal Autoregressive Integrated Moving Average (SARIMA) models and Generalized Additive Models (GAM)/ Generalized Additive Mixed Models (GAMM) using R software. AIC, BIC and residual tests were used to test the goodness of fit of SARIMA models, and R2 was used to select the best model in GAM/GAMM.

Results:
The SARIMA multivariate (1,0,1) (0,1,1)12 model, including the mean temperature and minimum humidity variables without lag, was the best fit. In nonlinear analysis, the number of malaria cases positively correlated with the month from January and peaked in May (edf=6.29). There was a generally negative correlation between malaria and time in years (edf=8.41). The mean temperature, between 20 to 30°C had the highest and slightly positive relation with the incidence of malaria (edf=7.55). Rainfall showed a negative association with small fluctuations between 20 and 45 mm and a positive association over 50 mm (edf=7.52). Mean relative humidity from above 50% had a negative relation with the number of cases (edf=6.93). The hours of sunshine in a month, until 235 hours, had a negative correlation and above 340 hours had a positive correlation with the incidence of malaria (edf=7.4).

Conclusion:
Meteorological variables can affect malaria occurrence.
Geochemical and Photochemical Constraints on S[IV] Concentrations in Natural Waters on Prebiotic Earth
Authors: Ranjan Sukrit , Abdelazim Khaled , Lozano Gabriella G , Mandal Sangita , Zhou Cindy Y , Kufner Corinna L , Todd Zoe R , Sahai Nita , Sasselov Dimitar D 
Published: November 2023

Aqueous S[IV] species (HSO,
SO) derived from volcanogenic
atmospheric SO are important to planetary habitability
through their roles in proposed origins-of-life chemistry and influence
on atmospheric sulfur haze formation, but the early cycling of S[IV]
is poorly understood. Here, we combine new laboratory constraints on
S[IV] disproportionation kinetics with a novel aqueous
photochemistry model to estimate the concentrations of S[IV] in
natural waters on prebiotic Earth. We show that S[IV]
disproportionation is slow in pH≥ 7 waters, with timescale T≥ 1 year at
room temperature, meaning that S[IV] was present in prebiotic
natural waters. However, we also show that photolysis of S[IV] by UV
light on prebiotic Earth limited [S[IV]]< 100μM in
global-mean steady-state. Because of photolysis, [S[IV]] was
much lower in natural waters compared to the concentrations generally
invoked in laboratory simulations of origins-of-life chemistry (≥ 10
mM), meaning further work is needed to confirm whether laboratory
S[IV]- dependent prebiotic chemistries could have functioned in
nature. [S[IV]]≥ 1μM in terrestrial waters for: (1)
SO outgassing ≥ 20× modern, (2) pond depths <
10 cm, or UV-attenuating agents present in early waters or the prebiotic
atmosphere. Marine S[IV] was sub-saturated with respect to
atmospheric SO, meaning that atmospheric
SO deposition was efficient and that, within the
constraints of present knowledge, UV-attenuating sulfur hazes could only
have persisted on prebiotic Earth if sulfur emission rates were very
high (≳ 100× modern). Our work illustrates the synergy between planetary
science, geochemistry and synthetic organic chemistry towards
understanding the emergence and maintenance of life on early Earth.
About the Pragmatic Features of the Mythological Prose of Altai
Authors: Ойноткинова Надежда Романовна , Тармаева Виктория Ивановна 
Published: November 2023

Статья посвящена прагматическим особенностям алтайских мифологических текстов в аспекте стратегии гармонизации. Данная гармонизация происходит по следующим направлениям: благодаря мифу человек адаптируется к окружающей действительности, миф выступает в качестве установки на координацию и согласование действий и отношения индивида к окружающему его природному миру; познание внешнего мира посредством мифа помогает индивиду осмыслить, сделать понятным («очеловечить») окружающую его действительность, нередко враждебную; мифологическое мировоззрение выступает в качестве системы базовых ориентиров, которые необходимы для интерпретации природных факторов и позволяют членам того или иного социума знать, каким образом следует построить свое поведение; мифы выступают в качестве установки, регулирующей и легитимирующей жизнь индивида и социума, поскольку в них содержатся объяснения и указания норм должного поведения и правильного восприятия окружающей действительности. Предложена типология тактик и приемов, используемых в текстах мифологической прозы алтайцев с целью гармонизации и упорядочения контекста восприятия реальности. Выделены различные тактики, используемые в текстах мифологической прозы алтайцев, в аспекте стратегии гармонизации, в частности утверждение, похвала, порицание, директивы, с помощью которых выражаются повествовательные императивы, а также тактики презентации, совета, похвалы/порицания и предостережения.
The article is devoted to the pragmatic features of the mythological texts of the Altai from the point of view of the harmonization strategy. This harmonization takes place in the following directions: thanks to the myth, man adapts to the surrounding reality; the myth coordinates the actions and attitudes of the individual towards the surrounding natural world; the perception of the external world through the myth helps the individual to make the surrounding reality understandable (“to humanize”); the mythological worldview functions as a system of basic guidelines necessary for the interpretation of natural factors, enabling members of a given society to know how to behave; myths regulate and legitimize the life of an individual and a society, as they contain explanations and indications of norms for the proper behavior and perception of environmental reality. The various tactics used in these texts are examined from the point of view of harmonizing strategy, especially the statement, praise, blame, directives used to express narrative imperatives, and tactics of presentation, advice, and warning.
Divergent veterinarian and cat owner perspectives are barriers to reducing the use of cefovecin in cats
Authors: Cazer Casey L. , Lawless Jeanne W. , Frye Amelia , Gonzalez Lecsy , Safi Amelia Greiner 
Published: November 2023

Abstract

OBJECTIVE
To understand veterinarian and cat owner perspectives on antimicrobial use in cats, reasons for prescribing cefovecin, and barriers to improving antimicrobial stewardship, including veterinarian and cat owner perspectives of giving oral medication to cats.

SAMPLE
21 New York veterinarians and 600 cat owners across the US.

METHODS
Cat owners were surveyed about their preferences for and experiences in giving oral medications to cats and their experiences with antimicrobials specifically. Veterinarians were interviewed about antimicrobial use decisions in cats, benefits and drawbacks of cefovecin, and their perspectives on antimicrobial resistance.

RESULTS
Many veterinarians reported feeling pressure to prescribe antimicrobials, while 41% of cat owners reported requesting antimicrobials. Although veterinarians are aware of the downsides of prescribing cefovecin, many prescribed cefovecin in situations where an antimicrobial was not needed or cefovecin may not have been the best choice. Veterinarians thought that 20% of cat owners could not give oral medications, but < 10% of cat owners had a cat that was impossible to medicate.

CLINICAL RELEVANCE
The disconnect between veterinarians’ assessment of and cat owners’ reported abilities in administering oral medication may contribute to cefovecin use. Demonstrating for cat owners how to give oral medication may help improve compliance and reduce the use of parenteral long-acting formulations. Structural and educational interventions are needed to address other contributors to inappropriate antimicrobial use. This research provides the specific considerations about barriers and motivations for cat owners and veterinarians that are required to guide strategic, tailored interventions for both audiences to advance stewardship.
Antiderivatives and Integration
Authors: Endou Noboru 
Published: November 2023

Summary
In this paper, we introduce indefinite integrals [8] (antiderivatives) and proof integration by substitution in the Mizar system [2], [3]. In our previous article [15], we have introduced an indefinite-like integral, but it is inadequate because it must be an integral over the whole set of real numbers and in some sense it causes some duplication in the Mizar Mathematical Library [13]. For this reason, to define the antiderivative for a function, we use the derivative of an arbitrary interval as defined recently in [7]. Furthermore, antiderivatives are also used to modify the integration by substitution and integration by parts.
In the first section, we summarize the basic theorems on continuity and derivativity (for interesting survey of formalizations of real analysis in another proof-assistants like ACL2 [12], Isabelle/HOL [11], Coq [4], see [5]). In the second section, we generalize some theorems that were noticed during the formalization process. In the last section, we define the antiderivatives and formalize the integration by substitution and the integration by parts. We referred to [1] and [6] in our development.