bluuebunny/crossref_metadata_2025_split huggingface dataset:
The frequency of complications in a cohort of patients diagnosed with hemophilia A and hemophilia B receiving prophylactic treatment in Colombia: A retrospective noninterventional study
Authors: Machado Alba Jorge E. , Wilches-Gutierrez Juan David , Arias-Osorio Diana Rocio , Reyes Juan Manuel , Nakandakari Maria Lourdes , Ospina-Arzuaga Harrison David , Gaviria-Mendoza Andres , Castaño-Gamboa Natalia , Valladales-Restrepo Luis Fernando , Machado-Duque Manuel E. 
Published: November 2023

Introduction
Hemophilia A and B are disorders associated with the deficit of coagulation factors VIII and IX.

Objective
Was to determine the incidence of complications in a cohort of patients diagnosed with moderate and severe hemophilia A or B under treatment in a specialized institution.

Methods
A retrospective study of a cohort of patients with replacement therapy for hemophilia A or B, evaluating treatment and complications between January/2012 and July/2019. Sociodemographic, clinical and disease management-related variables were extracted from the medical records. Time to inhibitor development and rate associated with bleeding and hospitalizations were evaluated.

Results
A total of 159 male patients were identified with hemophilia A (n = 140; 88.1%) and B (n = 19; 11.9%) with a mean follow-up of 5.9±2.3 years. The mean age was 23.6±16.1 years, hemophilia was reported as severe in 125 patients in hemophilia A (89.3%) and 13 patients in hemophilia B (68.4%). Primary prophylaxis was registered in 17.0% of patients, 44.7% secondary, and 38.3% tertiary, with recombinant factors (n = 84; 52.8%) followed by plasma derived factors (n = 75; 47.2%). The incidence of inhibitor development was 0.3 per 100 patients/year, with mean time to event of 509 days. The incidence of bleeding was 192 per 100 patients/year, especially at the joint (n = 99; 62.3%) and muscle (n = 25; 15.7%) level. The incidence of hospitalization was 3.7 per 100 patients/year.

Conclusions
The most common complication was joint bleeding which was expected in this type of patients. Low proportion of patients developed factor inhibitors during the follow up.
Meta-analysis of diagnostic accuracy of nucleic acid amplification tests for abdominal tuberculosis
Authors: Shen Yanqin , Fang Likui , Ye Bo , Yu Guocan 
Published: November 2023

Background
Abdominal tuberculosis (TB) is a severe extrapulmonary TB, which can lead to serious complications. Early diagnosis and treatment are very important for the prognosis and the diagnosis of abdominal TB is still difficult.

Methods
We searched PubMed, the Cochrane Library, Embase, China National Knowledge Infrastructure, and the Wanfang database for studies evaluating the diagnostic accuracy of NAATs for abdominal TB until August 2020. Any types of study design with full text were sought and included. The risk of bias was assessed using the Quality Assessment of Diagnostic Accuracy Studies tool. Subgroup analysis, meta-regression analysis and sensitivity analysis were used to explore the sources of heterogeneity. Stata version 15.0 with the midas command packages was used to carry out meta-analyses.

Results
We included a total of 78 independent studies from 53 articles; 64 with CRS as the reference standard, and 14 with culture as the reference standard. The pooled sensitivity, specificity, and the areas under summary receiver operating characteristic (SROC) curves (AUC) were 58% (51%–64%; I2 = 87%), 99% (97%–99%; I2 = 81%), and 0.92 (0.89–0.94) compared with CRS, respectively. The pooled sensitivity, specificity, and the AUC values of the SROC were 80% (66%–90%; I2 = 56%), 96% (92%–98%; I2 = 84%), and 0.97 (0.95–0.98) compared with culture, respectively. The heterogeneity of sensitivity and specificity was significant.

Conclusions
NAATs had excellent efficacy in the diagnosis of abdominal TB regardless of the reference standard and regardless of the subtype of abdominal TB. Multiplex PCR with multiple target genes may improve diagnostic sensitivity, and stool specimens may also be used for the diagnosis of abdominal TB in addition to tissue and ascites.
Type of anesthesia for cancer resection surgery: No differential impact on cancer recurrence in mouse models of breast cancer
Authors: Dubowitz Julia , Ziegler Alexandra I. , Beare Richard , Jost-Brinkmann Fabian , Walker Adam K. , Gillis Ryan D. , Chang Aeson , Chung Ni-Chun , Martin Olga A. , Hollande Frédéric , Riedel Bernhard , Sloan Erica K. 
Published: November 2023

Background
Surgery is essential for curative treatment of solid tumors. Evidence from recent retrospective clinical analyses suggests that use of propofol-based total intravenous anesthesia during cancer resection surgery is associated with improved overall survival compared to inhaled volatile anesthesia. Evaluating these findings in prospective clinical studies is required to inform definitive clinical guidelines but will take many years and requires biomarkers to monitor treatment effect. Therefore, we examined the effect of different anesthetic agents on cancer recurrence in mouse models of breast cancer with the overarching goal of evaluating plausible mechanisms that could be used as biomarkers of treatment response.

Methods
To test the hypothesis that volatile anesthesia accelerates breast cancer recurrence after surgical resection of the primary tumor, we used three mouse models of breast cancer. We compared volatile sevoflurane anesthesia with intravenous propofol anesthesia and used serial non-invasive bioluminescent imaging to track primary tumor recurrence and metastatic recurrence. To determine short-term perioperative effects, we evaluated the effect of anesthesia on vascular integrity and immune cell changes after surgery in animal models.

Results
Survival analyses found that the kinetics of cancer recurrence and impact on survival were similar regardless of the anesthetic agent used during cancer surgery. Vascular permeability, immune cell infiltration and cytokine profiles showed no statistical difference after resection with inhaled sevoflurane or intravenous propofol anesthesia.

Conclusions
These preclinical studies found no evidence that choice of anesthetic agent used during cancer resection surgery affected either short-term perioperative events or long-term cancer outcomes in mouse models of breast cancer. These findings raise the possibility that mouse models do not recapitulate perioperative events in cancer patients. Nonetheless, the findings suggest that future evaluation of effects of anesthesia on cancer outcomes should focus on cancer types other than breast cancer.
Investigating social determinants of child health and their implications in reducing pediatric traumatic injury: A framework and 17-year retrospective case-control study protocol
Authors: Goodon Hunter , Gawaziuk Justin , Comaskey Brenda , Afifi Tracie O. , Château Dan , Brownell Marni , Sareen Jitender , Morgan Cora , Logsetty Sarvesh , Spiwak Rae 
Published: November 2023

Introduction
Traumatic physical injuries are the number one cause of hospitalization and death among children in Canada. The majority of these injuries are preventable. The burden from injury can be reduced through prevention programs tailored to at-risk groups, however, existing research does not provide a strong explanation of how social factors influence a child’s risk of injury. We propose a theoretical framework to better understand social factors and injury in children and will examine the association between these social factors and physical traumatic injury in children using large population-wide data.

Methods and analysis
We will examine data from 11,000 children hospitalized for traumatic physical injury and 55,000 matched uninjured children by linking longitudinal administrative and clinical data contained at the Manitoba Centre for Health Policy. We will examine 14 social determinants of child health measures from our theoretical framework, including receipt of income assistance, rural/urban status, socioeconomic status, children in care, child mental disorder, and parental factors (involvement with criminal justice system, education, social housing, immigration status, high residential mobility, mother’s age at first birth, maternal Axis I mental disorder, maternal Axis II mental disorder and maternal physical disorder) to identify groups and periods of time when children are at greatest risk for traumatic physical injury. A conditional multivariable logistic regression model will be calculated (including all social determinant measures) to determine odds ratios and adjusted odds ratios (95% confidence interval) for cases (injured) and controls (non-injured).

Ethics and dissemination
Health Information Privacy Committee (HIPC No. 2017/2018-75) and local ethics approval (H2018-123) were obtained. Once social measures have been identified through statistical modelling, we will determine how they fit into a Haddon matrix to identify appropriate areas for intervention. Knowing these risk factors will guide decision-makers and health policy.
Using microbiological data to improve the use of antibiotics for respiratory tract infections: A protocol for an individual patient data meta-analysis
Authors: Boateng Irene , Stuart Beth , Becque Taeko , Barrett Bruce , Bostock Jennifer , Bruyndonckx Robin , Carr-Knox Lucy , Ciccone Emily J. , Coenen Samuel , Ebell Mark , Gillespie David , Hayward Gail , Hedin Katarina , Hood Kerenza , Lau Tin Man Mandy , Little Paul , Merenstein Dan , Mulogo Edgar , Ordóñez-Mena Jose , Muir Peter , Samuel Kirsty , Shaikh Nader , Tonner Sharon , van der Velden Alike W. , Verheij Theo , Wang Kay , Hay Alastair D. , Francis Nick 
Published: November 2023

Background
Resistance to antibiotics is rising and threatens future antibiotic effectiveness. ‘Antibiotic targeting’ ensures patients who may benefit from antibiotics receive them, while being safely withheld from those who may not. Point-of-care tests may assist with antibiotic targeting by allowing primary care clinicians to establish if symptomatic patients have a viral, bacterial, combined, or no infection. However, because organisms can be harmlessly carried, it is important to know if the presence of the virus/bacteria is related to the illness for which the patient is being assessed. One way to do this is to look for associations with more severe/prolonged symptoms and test results. Previous research to answer this question for acute respiratory tract infections has given conflicting results with studies has not having enough participants to provide statistical confidence.

Aim
To undertake a synthesis of IPD from both randomised controlled trials (RCTs) and observational cohort studies of respiratory tract infections (RTI) in order to investigate the prognostic value of microbiological data in addition to, or instead of, clinical symptoms and signs.

Methods
A systematic search of Cochrane Central Register of Controlled Trials, Ovid Medline and Ovid Embase will be carried out for studies of acute respiratory infection in primary care settings. The outcomes of interest are duration of disease, severity of disease, repeated consultation with new/worsening illness and complications requiring hospitalisation. Authors of eligible studies will be contacted to provide anonymised individual participant data. The data will be harmonised and aggregated. Multilevel regression analysis will be conducted to determine key outcome measures for different potential pathogens and whether these offer any additional information on prognosis beyond clinical symptoms and signs.

Trial registration
PROSPERO Registration number: CRD42023376769.
Efficacy of mesenchymal stromal cells in the treatment of unexplained recurrent spontaneous abortion in mice: An analytical and systematic review of meta-analyses
Authors: Zhao Xiaoxuan , Hu Yijie , Xiao Wenjun , Ma Yiming , Shen Dan , Jiang Yuepeng , Shen Yi , Wang Suxia , Ma Jing 
Published: November 2023

ObjectivesUnexplained recurrent spontaneous abortion (URSA) remains an intractable reproductive dilemma due to the lack of understanding of the pathogenesis. This study aimed to evaluate the preclinical evidence for the mesenchymal stromal cell (MSC) treatment for URSA.MethodsA meticulous literature search was independently performed by two authors across the Cochrane Library, EMBASE, and PubMed databases from inception to April 9, 2023. Each study incorporated was assessed using the Systematic Review Centre for Laboratory Animal Experimentation (SYRCLE) risk of bias tool. The amalgamated standardized mean difference (SMD) accompanied by 95% confidence interval (CI) were deduced through a fixed-effects or random-effects model analysis.ResultsA total of ten studies incorporating 140 mice were subjected to data analysis. The MSC treatment yielded a significant reduction in the abortion rate within the URSA model (OR = 0.23, 95%CI [0.17, 0.3],P<0.00001). Moreover, it elicited a positive modulatory impact on the expression profiles of several inflammatory cytokines in the decidual tissue of URSA murine models, inclusive of IL4 (SMD 1.63, 95% CI [0.39, 2.86],P= 0.01), IL10 (SMD 1.60, 95% CI [0.58, 2.61],P= 0.002), IFN-γ (SMD -1.66, 95%CI [-2.79, -0.52],P= 0.004), and TNF-α (SMD -1.98, 95% CI [-2.93, -1.04],P< 0.0001). Subgroup analyses underscored that the administration mode of intraperitoneal and uterine horn injections, and sources of bone MSCs and adipose-derived MSCs contributed positively to the expression of IL4, IL10, and decreased the expression of IFN-γ in decidual tissue of URSA (P<0.05). Conversely, the tail vein injections subgroup was observed with no statistical significance (P>0.05).ConclusionsThe findings underscore the considerable potential of MSCs in URSA therapy. Nonetheless, the demand for enhanced transparency in research design and direct comparisons between various MSC sources and administration routes in URSA is paramount to engendering robust evidence that could pave the way for successful clinical translation.
Enhancement of Hybrid SPEEK Based Polymer–Cyclodextrin-Silica Inorganic Membrane for Direct Methanol Fuel Cell Application
Authors: Kusworo Tutuk Djoko , Hakim Muhammad Fahmi , Hadiyanto H 
Published: November 2023

Direct methanol fuel cell (DMFC) is one of several types of fuel cells that use proton exchange membrane (PEM) as a liaison between the reaction at the cathode and anode. Polyether-ether ketone (PEEK) is one of the aromatic polymer that can be applied in DMFC because of its characteristics that are resistant to DMFC environment. The polymer is also quite easy in the sulfonation process using concentrated sulfuric acid. However the role of polyether-ether ketone as DMFC membrane material is still lack of advantage due to its low conductivity and therefore the modification is required to increase the value of proton conductivity of the membrane. The purpose of this experiment is to modify the membrane (sPEEK) with the addition of cyclodextrins-silica, additive variation charge of 2%, 6% and 10%, time and temperature were fixed at 4 hours and 65oC. The results showed the best results of membrane sPEEK was obtained at the addition of -cyclodextrin -silica 10% with the membrane characteristics of ion exchange capacity of 2.19 meq / g polymer, the degree of sulfonation of 81%, methanol permeability of 3.09 x 10-9 cm2 / s and water uptake membrane of 64%.Article History: Received January 18th 2017; Received in revised form April 21st 2017; Accepted June 22nd 2017; Available onlineHow to Cite This Article: Kusworo, T.D., Hakim, M.F. and Hadiyanto, H. (2017) Enhancement of Hybrid SPEEK Based Polymer–Cyclodextrin-Silica Inorganic Membrane for Direct Methanol Fuel Cell Application. International Journal of Renewable Energy Development, 6(2), 165-170.https://doi.org/10.14710/ijred.6.2.165-170
CSRD Sustainability Reporting For Non-listed SMEs: European Regulators Remain Challenged
Authors: Allgeier Sina , Feldmann Robert 
Published: November 2023

Abstract

438The recently adopted Corporate Sustainability Reporting Directive (CSRD) requires all large undertakings as well as listed SMEs to report on sustainability matters. Albeit not in the direct scope of the CSRD, non-listed SMEs will be de facto obliged by their business partners and investors to report accordingly. Hence, a separate reporting standard for non-listed SMEs is of pivotal importance. The CSRD, however, fails to endow the European Commission with the necessary delegated legislative power. Yet, EFRAG plans to develop standards specifically designed for non-listed SMEs. The European Commission may and should publish those standards as non-binding recommendations under Art. 288 para. 5 TFEU. Prior to that, the Commission must feed those standards into the endorsement procedure established by the CSRD regarding delegated acts.439
Intercreditor Agreement and Contractual Restructuring of LBOs
Authors: Lehtimäki Mika J. 
Published: November 2023

Abstract

547Leveraged buyout (LBO) transactions are corporate acquisitions financed with multiple layers of debt and equity and form a large subset of the leveraged finance markets. In European LBOs various creditor-categories, the priorities, control and restructuring options are invariably controlled by intercreditor agreements. They set out a basis for a privatised insolvency procedure. Such privatised procedures are often considered both theoretically and practically impossible because of the risk of strategic creditor actions, the incomplete contracting problem, the incentive effects of agency costs and the difficulties of creditor coordination.
This article sets out empirical findings how English law governed intercreditor agreements deal with strategic creditor actions and difficulties in creditor coordination, while creating a structured bargaining space for resolution of financial distress. The empirical analysis consists of content analysis of market ICAs and interviews.
I argue that contractual solutions for dealing with financial distress in corporate finance are both theoretically and practically possible. ICAs deal with the most important strategic creditor actions and enable effective restructuring to take place contractually. Also, they can operate between sophisticated multi-round players and without necessarily resorting to the statutory procedures.548
Online Formation of Companies – Serbian Experience and Way Forward
Authors: Jevremović Petrović Tatjana 
Published: November 2023

Abstract

481This paper aims at contributing to the existing debate on online formation of companies. It will analyse the current system of full online formation which is available in the Republic of Serbia since 2018 and put it into European perspective. Even though many challenges were related to the full online registration in general, the Republic of Serbia introduced this procedure relatively easy, even though amending the traditional system of registration on several occasions. The last amendments introduced exclusive online formation of companies which is applicable since mid-May 2023.
The most challenging issues in regard to full online registration were to accommodate existing system of preventive administrative and prevailingly formal dual control of formation procedure to be performed fully online. In that regard introduction and use of qualified electronic certificate provided high level of assurance in electronic identification, as one of cornerstones of online registration. Nevertheless, this system remained susceptible to negative effects and needs additional attention. It should be important that, beside efficiency, legal certainty and trust in business registers remain the most prominent features of formation of companies, not only in domestic, but above all in cross-border context.482
Kreislaufwirtschaft: Verzaubernde Perspektiven oder ein Mythos?
Authors: Klusch Christina , Rubik Frieder , Schöpflin Patrick 
Published: November 2023

Zusammenfassung
Die Transformation hin zu einer Kreislaufwirtschaft wird in Deutschland und der Europäischen Union als zentraler Teil einer nachhaltigen Entwicklung vorangetrieben. Die praktische Umsetzung steht jedoch noch am Anfang. Wir beleuchten vier Schlüsselbereiche, die „Bruchstellen“ zur bisherigen linearen Wirtschaft im Übergang zu einer Kreislaufwirtschaft darstellen: (1) die Digitalisierung zur Verbesserung des Informationsaustauschs und der Rückverfolgbarkeit von Produkten, (2) die Regionalisierung und Umstrukturierung von Lieferketten, (3) die Überwindung von Obsoleszenz zur Verlängerung der Produktlebensdauer und (4) die Förderung einer gemeinsamen Nutzung (Sharing) von Produkten und Ressourcen. Wir schließen mit Handlungsempfehlungen für Politik, Unternehmen und Bürger*innen.
Kreislaufwirtschaft hat Grenzen
Authors: Korduan Janine 
Published: November 2023

Zusammenfassung
Kreislaufwirtschaft und Recycling sind im Trend, aber haben ihre Grenzen – Stoffkreisläufe werden niemals hundertprozentig geschlossen werden können. Um innerhalb der Erdsystemgrenzen bzw. der planetaren und sozialen Grenzen zu wirtschaften, brauchen wir eine drastische Reduktion des Ressourcenverbrauchs. Ohne solche Ziele können die Klimakatastrophe und der Biodiversitätsverlust nicht aufgehalten werden. Der Bund für Umwelt und Naturschutz (BUND) fordert gemeinsam mit anderen zivilgesellschaftlichen Organisationen des Netzwerks „Ressourcenwende“ daher von der Bundesregierung, eine Gesetzesinitiative für ein Ressourcenschutzgesetz zu starten. Dieses muss absolute und messbare Ressourcenschutzziele beinhalten, die den Ressourcenverbrauch um ein Vielfaches reduzieren.
Kreislaufwirtschaft „an der Basis“ – Verpackungen und Konsumarbeit
Authors: Süßbauer Elisabeth 
Published: November 2023

Zusammenfassung
Bürger*innen werden in den vorherrschenden Kreislaufwirtschaftsdiskursen entweder passiv als Nutzer*innen von neuen Sharing- oder Reuse-Geschäftsmodellen dargestellt oder ihr individuelles Verhalten wird moralisiert, wobei Lebensmittelverpackungen besonders moralisch aufgeladen sind. Die Konsumarbeit, die hinter dem Umgang mit Lebensmittelverpackungen in Privathaushalten steckt, z. B. das Sammeln, Säubern, Sortieren, Kompostieren, Heraustragen und Einwerfen des Verpackungsmülls, wird dabei in der Regel ausgeblendet. Dieser Beitrag argumentiert, dass im Zuge der globalen Plastikkrise nicht nur das Mülltrennen, sondern auch die Müllvermeidung zur Aufgabe von Bürger*innen geworden ist. Um den Blick auf diese verborgene Konsumarbeit zu legen, werden empirische Einblicke in den alltäglichen Umgang von Bürger*innen mit Verpackungsmüll in deren häuslicher Umgebung geben. Die Ergebnisse zeigen erstens, dass Bürger*innen Wiederverwendung bereits auf „informelle Weise“ praktizieren, die Verwendung von Essensbehältern für fremd zubereite Speisen jedoch mit einem organisatorischen Aufwand und Absprachen innerhalb des Haushalts verbunden sind. Zweitens bestehen große Unsicherheiten beim Trennen und Sortieren von Verpackungsabfällen. Es wird geschlussfolgert, dass sich Bürger*innen in einem Spannungsfeld zwischen moralisiertem Alltagshandeln und dem Bemühen, es „richtig machen“ zu wollen, einem beschleunigten Alltag mit zunehmend flexibilisierten Ernährungsmustern sowie einer zeitlich und räumlich entgrenzten Erwerbsarbeit befinden. Damit möchte der Beitrag einer Versimplifizierung von Konsumverhalten entgegenwirken und zu einem komplexeren Verständnis der Rollen von Bürger*innen in Kreislaufwirtschaftsdiskursen beitragen.