bluuebunny/crossref_metadata_2025_split huggingface dataset:
SIRT3/6: an amazing challenge and opportunity in the fight against fibrosis and aging
Authors: Wei Wenxin , Li Tian , Chen Jinlong , Fan Zhen , Gao Feng , Yu Zhibiao , Jiang Yihao 
Published: January 2024

AbstractFibrosis is a typical aging-related pathological process involving almost all organs, including the heart, kidney, liver, lung, and skin. Fibrogenesis is a highly orchestrated process defined by sequences of cellular response and molecular signals mechanisms underlying the disease. In pathophysiologic conditions associated with organ fibrosis, a variety of injurious stimuli such as metabolic disorders, epigenetic changes, and aging may induce the progression of fibrosis. Sirtuins protein is a kind of deacetylase which can regulate cell metabolism and participate in a variety of cell physiological functions. In this review, we outline our current understanding of common principles of fibrogenic mechanisms and the functional role of SIRT3/6 in aging-related fibrosis. In addition, sequences of novel protective strategies have been identified directly or indirectly according to these mechanisms. Here, we highlight the role and biological function of SIRT3/6 focus on aging fibrosis, as well as their inhibitors and activators as novel preventative or therapeutic interventions for aging-related tissue fibrosis.
Graphical abstract
The dual role of autophagy in HPV-positive head and neck squamous cell carcinoma: a systematic review
Authors: Kandathil Sam Augustine , Akhondi Arian , Kadletz-Wanke Lorenz , Heiduschka Gregor , Engedal Nikolai , Brkic Faris F. 
Published: January 2024

Abstract
Purpose
Human papilloma virus (HPV)-positive head and neck squamous cell carcinoma (HNSCC) displays distinct epidemiological, clinical, and molecular characteristics compared to the negative counterpart. Alterations in autophagy play an important role in cancer, and emerging evidence indicates an interplay of autophagy in HNSCC carcinogenesis and tumor promotion. However, the influence of HPV infection on autophagy in HNSCC has received less attention and has not been previously reviewed. Therefore, we here aimed to systematically review the role of autophagy explicitly in HPV+ HNSCC.

Methods
Studies accessible in PubMed, Embase, Scopus, and Web of Science investigating HNSCC, highlighting the molecular biological differences between HPV− and HPV+ HNSCC and its influences on autophagy in HNSCC were analyzed according to the PRISMA statement. A total of 10 articles were identified, included, and summarized.

Results
The HPV16 E7 oncoprotein was reported to be involved in the degradation of AMBRA1 and STING, and to enhance chemotherapy-induced cell death via lethal mitophagy in HNSCC cells. Autophagy-associated gene signatures correlated with HPV-subtype and overall survival. Additionally, immunohistochemical (IHC) analyses indicate that high LC3B expression correlates with poor overall survival in oropharyngeal HNSCC patients.

Conclusion
HPV may dampen general bulk autophagic flux via degradation of AMBRA1 but may promote selective autophagic degradation of STING and mitochondria. Interpretations of correlations between autophagy-associated gene expressions or IHC analyses of autophagy-related (ATG) proteins in paraffin embedded tissue with clinicopathological features without biological validation need to be taken with caution.
Imaging phase objects through diffusers based on lensless digital holography
Authors: Watanabe Wataru , Asada Shota , Kiyosumi Masaaki , Arimoto Hidenobu 
Published: January 2024

AbstractImaging of phase objects behind scattering media is a challenging task. Intensity imaging through diffusers can be achieved based on digital holography by obtaining the complex amplitude of the diffuser in advance. As described in this paper, we experimentally demonstrate the reconstructed images of phase objects behind diffusers with different diffusion angles by digital holography. Using the complex amplitude information of the diffuser to correct the complex amplitude information of the object through the diffuser, the phase distribution of the object is obtainable behind the diffuser. Imaging of phase objects behind diffusers has been verified through experiments using a plano-convex lens and a wedge substrate as phase objects with various scattering angles. Quantitative analyses of the phase objects are performed. The lens shape can be visualized from the known refractive index. Moreover, the curvature radius can be estimated.
Pragmatic randomized controlled trial comparing a complex telemedicine-based intervention with usual care in patients with chronic conditions
Authors: Sten-Gahmberg Susanna , Pedersen Kine , Harsheim Ingrid Gaarder , Løyland Hanna Isabel , Snilsberg Øyvind , Iversen Tor , Godager Geir , Sæther Erik Magnus , Abelsen Birgit 
Published: January 2024

AbstractThis study evaluates a complex telemedicine-based intervention targeting patients with chronic health problems. Computer tablets and home telemonitoring devices are used by patients to report point-of-care measurements, e.g., blood pressure, blood glucose or oxygen saturation, and to answer health-related questions at a follow-up center. We designed a pragmatic randomized controlled trial to compare the telemedicine-based intervention with usual care in six local centers in Norway. The study outcomes included health-related quality of life (HRQoL) based on the EuroQol questionnaire (EQ-5D-5L), patient experiences, and utilization of healthcare. We also conducted a cost–benefit analysis to inform policy implementation, as well as a process evaluation (reported elsewhere). We used mixed methods to analyze data collected during the trial (health data, survey data and interviews with patients and health personnel) as well as data from national health registers. 735 patients were included during the period from February 2019 to June 2020. One year after inclusion, the effects on the use of healthcare services were mixed. The proportion of patients receiving home-based care services declined, but the number of GP contacts increased in the intervention group compared to the control group. Participants in the intervention group experienced improved HRQoL compared to the control group and were more satisfied with the follow-up of their health. The cost–benefit of the intervention depends largely on the design of the service and the value society places on improved safety and self-efficacy.
Submesoscale variability on the edge of Kuroshio-shed eddy in the northern South China Sea observed by underwater gliders
Authors: Yang Haiyuan , Gao Zhiyuan , Ma Ke , Chen Zhaohui , Wang Yanhui , Jing Zhiyou , Ma Xin , Niu Wendong 
Published: January 2024

AbstractBased on a submesoscale-resolving glider observation from April 25 to May 4, 2018, characteristics and underlying dynamics of submesoscale variability at the edge of an anticyclonic eddy shed from Kuroshio in the Northern South China Sea are explored in this study. Three underwater gliders traveled across the frontal zone and implemented ~ 300 dives, covering a horizontal distance of ~ 160 km and a vertical depth of ~ 500 m in 9 days. The character of k−2 slope for spectral potential energy and the strong lateral buoyancy gradient indicate frontogenesis-induced submesoscale motions on the eddy edge. Further analysis focusing on the potential vorticity and balanced Richardson number reveals the development of symmetric instability (SI), which is associated with the strong lateral gradient of buoyancy at the edge of the anticyclonic eddy in the late spring.
Decoding the regulatory landscape of lncRNAs as potential diagnostic and prognostic biomarkers for gastric and colorectal cancers
Authors: Zabeti Touchaei Arefeh , Vahidi Sogand , Samadani Ali Akbar 
Published: January 2024

AbstractColorectal cancer (CRC) and gastric cancer (GC) are major contributors to cancer-related mortality worldwide. Despite advancements in understanding molecular mechanisms and improved drug treatments, the overall survival rate for patients remains unsatisfactory. Metastasis and drug resistance are major challenges contributing to the high mortality rate in both CRC and GC. Recent research has shed light on the role of long noncoding RNAs (lncRNAs) in the development and progression of these cancers. LncRNAs regulate gene expression through various mechanisms, including epigenetic modifications and interactions with microRNAs (miRNAs) and proteins. They can serve as miRNA precursors or pseudogenes, modulating gene expression at transcriptional and post-transcriptional levels. Additionally, circulating lncRNAs have emerged as non-invasive biomarkers for the diagnosis, prognosis, and prediction of drug therapy response in CRC and GC. This review explores the intricate relationship between lncRNAs and CRC/GC, encompassing their roles in cancer development, progression, and chemoresistance. Furthermore, it discusses the potential of lncRNAs as therapeutic targets in these malignancies. The interplay between lncRNAs, miRNAs, and tumor microenvironment is also highlighted, emphasizing their impact on the complexity of cancer biology. Understanding the regulatory landscape and molecular mechanisms governed by lncRNAs in CRC and GC is crucial for the development of effective diagnostic and prognostic biomarkers, as well as novel therapeutic strategies. This review provides a comprehensive overview of the current knowledge and paves the way for further exploration of lncRNAs as key players in the management of CRC and GC.
Graphical Abstract
On the balanced truncation error bound and sign parameters from arrowhead realizations
Authors: Reiter Sean , Damm Tobias , Embree Mark , Gugercin Serkan 
Published: January 2024

AbstractBalanced truncation and singular perturbation approximation for linear dynamical systems yield reduced order models that satisfy a well-known error bound involving the Hankel singular values. We show that this bound holds with equality for single-input, single-output systems, if the sign parameters corresponding to the truncated Hankel singular values are all equal. These signs are determined by a generalized state-space symmetry property of the corresponding linear model. For a special class of systems having arrowhead realizations, the signs can be determined directly from the off-diagonal entries of the corresponding arrowhead matrix. We describe how such arrowhead systems arise naturally in certain applications of network modeling and illustrate these results with a power system model that motivated this study.
Portia spider algorithm: an evolutionary computation approach for engineering application
Authors: Pham Vu Hong Son , Nguyen Dang Nghiep Trinh 
Published: January 2024

AbstractThe Portia spider, a notable member of the jumping spider family (Salticidae), is widely recognized for its intricate hunting strategies and remarkable problem-solving prowess. Several species fall under the “Portia” genus, with habitats spanning regions in Africa, Asia, and Australia. Demonstrating the ability to tackle new challenges, these spiders can learn and adapt their strategies based on prior experiences. This study introduces the Portia Spider Algorithm (PSA), a swarm-based technique inspired by the unique predatory strategies of the Portia spider. We conducted rigorous assessments of PSA performance against 23 classical test functions, 29 CEC2017 test cases, and 5 engineering optimization tasks. To demonstrate the effectiveness of the PSA, outcomes were juxtaposed with those of renowned algorithms. This paper explores the mechanics, advantages, and potential applications of PSA within the vast domain of computational optimization.
Graphical Abstract
Citizen scientists filling knowledge gaps of phosphate pollution dynamics in rural areas
Authors: Loiselle Steven , Bishop Isabel , Moorhouse Heather , Pilat Caroline , Koelman Eline , Nelson Rosie , Clymans Wim , Pratt John , Lewis Vaughn 
Published: January 2024

AbstractIn situ monitoring is fundamental to manage eutrophication in rivers and streams. However, in recent decades, the frequency and spatial coverage of regulatory monitoring have often been reduced due to funding and infrastructure limitations. This reduction has made it impossible to provide adequate coverage for most water bodies. In this study, trained citizen scientists filled spatial and temporal gaps in agency monitoring across a major catchment in rural England. By integrating data from citizen scientists, regulatory agencies, and the local water company, it was possible to demonstrate the opportunities for hypothesis-based citizen scientist monitoring to identify continuous and event-driven sources of phosphate pollution. Local citizen scientists effectively covered important spatial gaps, investigating river conditions both upstream and downstream of suspected pollution point sources, improving the identification of their temporal dynamics. When combined with long-term monitoring data from regulatory agencies, it became possible to identify areas within the catchment that exhibited increased phosphate concentrations during periods of low river discharge (summer). Inter-annual trends and anomaly detection suggested that continuous pollution sources dominated over event-driven sources in many sub-basins, allowing for the prioritisation of mitigation actions. This study highlights the opportunity for citizen scientists to fill gaps in regulatory monitoring efforts and contribute to the improved management of eutrophication in rural catchments.
Working for the environment: farmer attitudes towards sustainable farming actions in rural Wales, UK
Authors: Follett Elizabeth , Davis Lorna , Wilson Catherine , Cable Jo 
Published: January 2024

AbstractRecognition of land management impacts on water quality and flooding, and climate change-induced increases in storm intensity and flood risk, have led to interest in farmer provision of ecosystem services alongside food production. However, pathways for practical design and funding of agroecological interventions are less well understood. Effective design and implementation of sustainable farming initiatives have been linked to human-centred aspects including stakeholder engagement and provision of social and economic co-benefits. To obtain information on Welsh farmer perspectives on sustainable farming actions and aid development of agroecological policy and design guidance, Welsh farmer perspectives on sustainable farming were obtained through discussion, online polls, and questionnaires. Participant-identified barriers to action included incorporation of return on initial time and cost investment in long-term farm budgets, occurrence of extreme weather events, and tenanted land. Decision-making processes were rooted in community discussion to balance perceived needs of the land and farm business, with communication preferences expressed for bilingual farm advice provision and support of farmer-to-farmer knowledge transfer pathways. In addition to responding to research questions, participants identified interdependent components of economic, social, cultural, and environmental sustainability necessary to achieve positive environmental outcomes, and expressed environmentally oriented farming identities linked to environmental guardianship and caretaking. Design of tree-planting schemes was discussed as an example of this interlinkage, with positive attitudes expressed for land sharing at small spatial scales, but not at the whole-farm scale.
Gravitational waves on charged black hole backgrounds in modified gravity
Authors: Barroso Varela Miguel , Rauch Hugo 
Published: January 2024

AbstractThe stability of Reissner–Nördstrom black holes with an extremal mass–charge relation was determined by calculating the propagation speed of gravitational waves on this background in an effective field theory (EFT) of gravity. New results for metric components are shown, along with the corresponding new extremal relation, part of which differs by a global factor of 2 from the past published work. This new relation further develops the existing constraints on EFT parameters. The radial propagation speed for gravitational waves in the Regge–Wheeler gauge was calculated linearly for all perturbations, yielding exact luminality for all dimension-4 operators. The dimension-6 radial speed modifications introduce no constraints on the sign of the modified theory parameters from causality arguments, while the deviation from classical theories vanishes at both horizons. The angular speed was found to be altered for the dimension-4 operators, with possible new constraints on the modified theory being suggested from causality arguments. Results are consistent with existing literature on Schwarzschild black hole backgrounds, with some EFT terms becoming active only in non-vacuum spacetimes such as Reissner–Nördstrom black holes.
The influence of lifestyle and biological factors on semen variability
Authors: Lyons Hannah E. , Gyawali Prabin , Mathews Nicola , Castleton Patience , Mutuku Shadrack M. , McPherson Nicole O. 
Published: January 2024

Abstract
Purpose
Semen parameters are subjected to within-individual variability over time. The driving factors for this variability are likely multi-factorial, with healthier lifestyle associated with better semen quality. The extent in which variations in individual’s lifestyle contributes to within-individual semen variability is unknown.

Methods
A total of 116 repeat semen samples from 29 men aged 19–37 over 6 months were collected. Basic semen analysis as per 5th WHO manual and extended semen parameters (sperm DNA fragmentation, redox potential and lipid peroxidation, sperm binding to hyaluronan and hyperactive motility) were assessed. An additional 39 lifestyle/biological factors (weight, blood pressure, etc.) were collected at each sample including validated health questionnaires SF36 Health Status, Australian Recommend Food Score, and International Physical Activity Questionnaire.

Results
Only 10 out of the 39 lifestyle factors varied within men across samples including age (P = 0.0024), systolic blood pressure (P = 0.0080), social functioning (P = 0.0340), energy (P = 0.0069), non-alcoholic caffeinated beverages (P = 0.0010), and nutrition (P < 0.0001). The only semen parameter that varied between collections was sperm morphology (coefficient of variation 23.8 (6.1–72.0), P < 0.05). We only observed weak (r < 0.3) to moderate (r > 0.3– < 0.6) correlations between lifestyle factors, including body mass index, waist circumference, nutrition, exercise, blood pressure and semen parameters including sperm count, progressive motility, and sperm DNA fragmentation (P < 0.05).

Conclusion
In healthy men from the general population, semen quality and associated lifestyle factors do not significantly vary over 6 months, indicating that one semen sample is likely sufficient for determining male fertility in this population.
Digital twin for product versus project lifecycles’ development in manufacturing and construction industries
Authors: Abanda F. H. , Jian N. , Adukpo S. , Tuhaise V. V. , Manjia M. B. 
Published: January 2024

Abstract
Digital twin, as an important enabling tool for digital transformation, has received increasing attention from researchers and practitioners since its definition was formalised. Especially in the global context and exacerbated by Covid-19, the applications of the digital twin have offered opportunities for many industries. While the digital twin has already been widely used in many sectors such as manufacturing and the construction industry—one of the key engines of economic development, is still lagging behind many other sectors. This study uses the systematic literature review to assess the applications of digital twin in manufacturing and construction respectively, the benefits it brings, and the impediments to its application. Based on this, a comparison is made of digital twin applications in the manufacturing and construction industries to draw lessons. This study concluded that although the use of digital twin in manufacturing is better than construction overall, it is still not reaching its full potential. Despite many benefits brought by the digital twin to construction during the project lifecycle, the construction sector faces even greater challenges than manufacturing in digital twin adoption. By comparison, this study drew five lessons to drive better adoption of the digital twin. The construction industry needs to accelerate the deployment of relevant hardware, promote the standard unification of digital twin, explore the whole lifecycle application of the digital twin, enhance data protection, and embrace changes. This study was limited in the scope of data collection. Future research could focus on gathering information from specific case studies, to produce more comprehensive perspectives.
Knowledge, Attitude, and Practices Towards COVID-19 Among Pregnant and Postpartum Women in Rural Bangladesh: A Cross-Sectional Study
Authors: Gunawardhana Gayani , Rokonuzzaman S. M. , Islam Sajia , Alarm Neeloy , Ferdous Tarana E , Kirkwood Elizabeth K , Raynes-Greenow Camille , Billah Sk Masum 
Published: January 2024

Abstract
Objective
To identify knowledge, attitudes, and practices toward COVID-19 among pregnant and postpartum women in rural Bangladesh, and to assess any association with antenatal care attendance (ANC).

Methods
This cross-sectional study was conducted in Northern Bangladesh’s Sherpur district with a sample of pregnant and post-partum women enrolled in ‘Poriborton’, a community-based cluster Randomised Controlled Trial. Knowledge, attitude, and practices toward COVID-19, and any association with antenatal care practices were assessed through face-to-face interviews using a structured questionnaire. Composite measures for knowledge, attitude, and practices of COVID-19 were generated. Specific knowledge on COVID-19 and the association of antenatal care were presented as descriptive statistics. An adjusted odds ratio was used to examine the association between categorical variables.

Results
Out of 4835 women, 34.0% correctly identified five or more COVID-19 symptoms, 31.8% knew three or more modes of coronavirus transmission, and 57.0% knew five or more preventive measures. Most (90.1%) had a “more positive attitude to testing” and 65.1% reported adequate practice of preventive measures. Women with adequate knowledge of COVID-19 were more likely to report both a positive attitude to testing (OR:2.96; 95% CI: 1.38–6.37) and adopt adequate practices of preventive measures (OR: 4.30;95% CI: 2.90–6.36). Education and being employed influenced KAP related to COVID-19. Only 14.9% were satisfied with their knowledge of COVID-19. Television was the main source of COVID-19-related specific information.

Conclusions
We found that improved knowledge was associated with positive attitudes and behaviours that lead to the adoption of preventive measures. There was no association with ANC practices as attendance was very low in this region. The findings could be utilised to develop communication strategies for future public health emergencies in similar settings.