bluuebunny/crossref_metadata_2025_split huggingface dataset:
Orphan nuclear receptorNR2E3and its small-molecule agonist induce cancer cell apoptosis through regulating p53, IFNα and MYC pathways
Authors: Wang Yidan , Kroll Todd , Hao Linhui , Sharma Ansul , Zhou Vivian , Moat Luke , Mayer John , Shukla Sanjay S. , Hebbring Scott , Guo Song , Iden Marissa , Bissonnette Adam , Ananiev Gene , Parashar Deepak , Rader Janet S. , Janz Siegfried , Wen Zhi 
Published: December 2023

AbstractOrphan nuclear receptor NR2E3 activates p53 and induces cancer cell apoptosis. Further studies on p53-dependent and -independent functions of wild-type and mutatedNR2E3are needed. Herein, we showed that NR2E3 enhanced p53-DNA interactions in diverse cancer cells and up-regulated p53 and IFNα pathways while down-regulating MYC pathway in cervical cancer cells. Studies of “AllofUs” and TCGA databases showedNR2E3nonsynonymous mutations’ associating with four cancers. We stratifiedNR2E3SNVs for their cancer implications with the p53 reporter. A cancer-associatedNR2E3R97Hmutation not only lost the wild-type’s tumor-suppressing functions but also prohibited the wild-type from enhancing p53 acetylation. These observations implicated the potential for pharmaceutically activating NR2E3 to suppress cancer. Indeed, NR2E3’s small-molecule agonist 11a repressed 2-D and 3-D cultures of primary cells and cell lines of cervical cancer, in which screening FDA-approved anti-cancer drugs identified HDAC-1/2 inhibitor Romidepsin operating synergistically with 11a. The underlying molecular mechanisms included 11a’s down-regulating the transcription of Multidrug Resistance ProteinABCB1that Romidepsin up-regulated. Transcriptomics studies revealed three synergy modes: (1) “sum-up” mode that the p53 pathway activated individually by 11a and Romidepsin got stronger by the combo; (2) “antagonism” mode that Romidepsin counteracted the activation of the Kras pathway by 11a; and (3) “de novo” mode that the combo instead of each individual drug repressed the MYC pathway. Conclusively, our experiments provide new data supporting tumor-suppressor like functions for wild-typeNR2E3, reveal roles of mutatedNR2E3in cancer, and address values of NR2E3’s agonist 11a in cancer therapy alone and combined.
Participation unpacked: participants' perceptions of its meaning and scope
Authors: Källström Lisa , Smith Elin 
Published: December 2023

PurposeThe concept of “participation” has become a buzzword in contemporary public governance models. However, despite the broad and significant interest, defining participation remains a debated topic. The aim of the current study was to explore how participants perceived and interpreted the meaning and scope of participation.Design/methodology/approachThis study is part of a four-year (2019–2022) longitudinal research project investigating stakeholder participation in the context of developing and establishing a strategic regional plan in Region Skåne in southern Sweden. The research project has a qualitative approach and uses interviews with different stakeholder groups such as municipal politicians and public officials and a survey as empirical material.FindingsThe authors developed a participation spectrum including eight types of participation: to be open, to be informed, to be listened to, to discuss, to be consulted, to give and take, to collaborate and to co-create. The authors also identified four different purposes of participation: creating a joint network, creating a joint understanding, creating a joint effort and creating a joint vision. The spectrum and the purposes were related through four characteristics of participation, i.e. involvement, interaction, influence and empowerment.Research limitations/implicationsThe study rests on a single case, and so the results have limited transferatibility.Originality/valueResearching participation in terms of the participants' perceptions contributes a new perspective to the existing literature, which has commonly focussed on the organizers' perceptions of participation. Moreover, in order to clarify what participation meant to the participants, the study puts emphasis on untangling this from the why question of participation.
Work–family conflict and behavioral outcomes of Chinese female leaders: the mechanisms of work–family guilt and family centrality
Authors: Chen Yuling , Yuan Zihan , Chen Charles Weizheng 
Published: December 2023

Purpose
The purpose of this study is to explore the impact of work-to-family conflict (WFC) on unethical pro-family behavior (UPFB) and work engagement (WE) among Chinese female leaders. In addition, this study investigates the mediating role of work-to-family guilt (WFG) and the moderating role of family centrality (FC) in these relationships.

Design/methodology/approach
A quantitative approach was adopted, involving the collection of data through online questionnaires administered at three time points. These data were analyzed using hierarchical regression and the bootstrapping method to test the proposed hypotheses.

Findings
WFC exhibited a significant positive correlation with UPFB and a negative correlation with WE; WFG played a mediating role in the relationships between WFC and both UPFB and WE; and FC had a significant moderating effect on the relationship between WFC and WE.

Originality/value
This study sheds light on a model of WFC and its related effects, reveals how WFC affects UPFB and WE and uncovers the mediating role of WFG and the moderating role of FC; pays attention to a unique organizational behavior, UPFB, which enriches research on the antecedents influencing such behaviors; and examines Chinese female leaders in organizations, their current experience of WFC and the resulting psychological and behavioral outcomes.
Investing in a leveraged world
Authors: Ahn Keunbae , Hambusch Gerhard , Hong Kihoon , Navone Marco 
Published: December 2023

PurposeThroughout the 21st century, US households have experienced unprecedented levels of leverage. This dynamic has been exacerbated by income shortfalls during the COVID-19 crisis. Leveraging and deleveraging decisions affect household consumption. This study investigates the effect of the dynamics of household leverage and consumption on the stock market.Design/methodology/approachThe authors explore the relation between household leverage and consumption in the context of the consumption capital asset pricing model (CCAPM). The authors test the model's implication that leverage has a negative risk premium by transforming the asset pricing restriction into an unconditional linear factor model and estimate the model using the general method of moments procedure. The authors run time-series regressions to estimate individual stocks' exposures to leverage, and cross-sectional regressions to investigate the leverage risk premium.FindingsThe authors show that shocks to household debt have strong and lasting effects on consumption growth. The authors extend the CCAPM to accommodate this effect and find, using various test assets, a negative risk premium associated with household deleveraging. Looking at individual stocks the authors show that the deleveraging risk premium is not explained by well-known risk factors.Originality/valueThis paper contributes to the literature on the role of leverage in economics and finance by establishing a relation between household leverage and spending decisions. The authors provide novel evidence that households' leveraging and deleveraging decisions can be a fundamental and influential force in determining asset prices. Further, this paper argues that household leverage might explain the small, persistent, and predictable component in consumption growth hypothesised in the long-run risk asset pricing literature.
Work-related computing at home and nonwork-related computing at work: a self-determination perspective
Authors: Wang Tingxi , Lin Qianyu , Zong Zhaobiao , Zhou Yue 
Published: December 2023

PurposeThis study investigates why employees' cyber-loafing is affected by work-related computing at home. Based on the self-determination theory, the authors propose the mediating role of sense of control and the moderating role of work/family segmentation preference.Design/methodology/approachTo test the authors' hypotheses, the authors conducted a multi-wave, multi-source field study with 224 paired employee-leader dyads at three time points. The hypotheses were tested by the SPSS macro application in Hayes (2018) with a bootstrap approach to obtain confidence intervals.FindingsThe work-related computing at home promotes employee cyber-loafing as compensation for their impaired sense of control. Moreover, such a relationship is stronger for employees with a stronger desire for self-control (i.e. high work/family segmentation preference).Originality/valueThis study reveals the underlying mechanism linking the work-related computing at home and employee cyber-loafing, as well as the boundary condition of this relationship. Specifically, sense of control serves as a vital mechanism and work/family segmentation preference as a key boundary condition. In addition, the authors enrich the application of self-determination theory in management research.
Information sharing format preferences under different supply chain power structures
Authors: Sun Haining , Cai Jianhu 
Published: December 2023

Purpose
This paper aims to study the preferences of the supply chain (SC) members on various power structures under demand information asymmetry considering competing retailers.

Design/methodology/approach
A two-level SC with one manufacturer and two retailers is designed. The retailers are in Bertrand competition. The manufacturer who holds the confidential demand information chooses the appropriate information sharing (IS) format. Three IS formats are provided, i.e. no IS (the manufacturer never shares with the retailers), partial IS (the manufacturer shares with one retailer), full IS (the manufacturer shares with all retailers). In addition, the authors model two power structures based on the decision sequences in the SC, i.e. retailers or manufacturer-dominant SC. The authors characterize the equilibrium solutions and payoffs and then investigate the members’ preferences for IS formats.

Findings
It is shown that in retailers (manufacturer)-dominant SC, the retailers prefer full (no) IS, but the manufacturer prefers no (full) IS. Moreover, the authors analyze the members’ preferences on power structures under demand information asymmetry, which has a relationship with the degrees of demand uncertainty and competition intensity.

Originality/value
The analysis regarding the preferences of the SC members on power structure under demand information asymmetry provides valuable managerial insights to enhance cooperation and achieve a win-win result.
“They act like we are going to heaven”: pre-arrival information experiences, information crafting and settlement of immigrants in Canada
Authors: Shuva Nafiz Zaman 
Published: December 2023

PurposeAlthough there is a growing body of work on immigrants' information behavior, little is known about the pre-arrival information experiences of immigrants who consult formal information sources such as immigration agents. Drawn from a larger study on the information behavior of immigrants, this paper mainly reports the semi-structured interview findings on the pre-arrival information experiences of Bangladeshi immigrants who used formal information sources with discussion on how that affected their post-arrival settlement into Canada.Design/methodology/approachThe study used a mixed method approach with semi-structured interviews (n = 60) and surveys (n = 205) with participants who arrived in Canada between the years of 1971 and 2017. Data were collected from May 2017 to February 2018.FindingsAlthough the overall scope of the original study is much larger, this paper features findings on the pre-arrival information experiences derived mainly from an analysis of interview data. This study provides insights into the pre-arrival information experiences of Bangladeshi immigrants consulting formal information sources such as immigration firms, individual immigration consultants and more formal government agencies. The author introduces a new concept of “information crafting” by exploring the negative consequences of selective information sharing by immigration consultants/agents in newcomers' settlements in Canada, primarily positive information about life in Canada, sometimes with exaggeration and falsification. The interview participants shared story after the story of the settlement challenges they faced after arriving in Canada and how the expectations they built through the information received from immigration consultants and government agencies did not match after arrival. This study emphasizes the importance of providing comprehensive information about life in Canada to potential newcomers so that they can make informed decisions even before they apply.Originality/valueThe findings of this study have theoretical and practical implications for policy and research. This study provides insights into the complicated culturally situated pre-arrival information experiences of Bangladeshi immigrants. Moreover, the study findings encourage researchers in various disciplines, including psychology, migration studies and geography, to delve more deeply into newcomers' information experiences using an informational lens to examine the information newcomers receive from diverse sources and their effects on their post-arrival settlement in a new country. The study challenges the general assumptions that formal information sources are always reputable, useful, and comprehensive, and it provides some future directions for research that seeks to understand the culturally situated information behavior of diverse immigrant groups.
In search of a coherent theoretical foundation for LIS ethical principles: an appraisal of Floridi's Information Ethics
Authors: Yu Liangzhi , Zhang Yao 
Published: December 2023

PurposeThis study aims to examine the potential of Information Ethics (IE) to serve as a coherent ethical foundation for the library and information science profession (LIS profession).Design/methodology/approachThis study consists of two parts: the first part present IE’s central theses and the main critiques it has received; the second part offers the authors' own evaluation of the theory from the LIS perspective in two steps: (1) assessing its internal consistency by testing its major theses against each other; (2) assessing its utility for resolving frequently debated LIS ethical dilemmas by comparing its solutions with solutions from other ethical theories.FindingsThis study finds that IE, consisting of an informational ontology, a fundamental ethical assertion and a series of moral laws, forms a coherent ethical framework and holds promising potential to serve as a theoretical foundation for LIS ethical issues; its inclusion of nonhuman objects as moral patients and its levels of abstraction mechanism proved to be particularly relevant for the LIS profession. This study also shows that, to become more solid an ethical theory, IE needs to resolve some of its internal contradictions and ambiguities, particularly its conceptual conflations between internal correctness, rightness and goodness; between destruction, entropy and evil; and the discrepancy between its deontological ethical assertion and its utilitarian moral laws.Practical implicationsThis study alerts LIS professionals to the possibility of having a coherent ethical foundation and the potential of IE in this regard.Originality/valueThis study provides a systemic explication, evaluation and field test of IE from the LIS perspective.
Do teacher beliefs mediate leadership and teacher behaviors? Testing teacher self-efficacy's mediation role between leadership for learning and teacher outcomes
Authors: Ahn Joonkil , Bowers Alex J. 
Published: December 2023

PurposeLeadership for learning emerged as an integrated leadership framework; however, attempts to establish an empirical measurement model have been limited. Critically, not much is known about how much teachers' beliefs (e.g. self-efficacy) can mediate leadership for learning impact on teacher behaviors. This study establishes a leadership for learning measurement model and examines whether teacher self-efficacy mediates the effect of leadership for learning tasks on teacher collaboration, instructional quality, intention to leave current schools and their confidence in equitable teaching practice.Design/methodology/approachDrawing on the most recent 2018 Teaching and Learning International Survey (TALIS), the study employed a structural equation modeling mediation approach.FindingsResults suggested that teacher self-efficacy statistically significantly mediated 16 out of 20 of the relationships between leadership for learning task domains and teacher outcomes. Especially, in explaining the variance in instructional quality and teacher confidence in implementing equitable teaching practices, considerable proportions of the predictive power of leadership for learning tasks were accounted for (i.e. mediated) by teacher self-efficacy.Research limitations/implicationsSchool-wide efforts to craft the school vision for learning must be coupled with enhancing teacher self-efficacy. Critically, leadership efforts may fall short of implementing equitable teaching practice and quality instruction without addressing teacher confidence in their ability in instruction, classroom management and student engagement.Originality/valueThis study is the first of its kind to evidence teacher self-efficacy mediates leadership for learning practice impact on teacher behaviors.
A perspective of international performance improvement concentrating on innovation and digital resilience of SMEs: the case of an emerging economy
Authors: Razavi Hajiagha Seyed Hossein , Alaei Saeed , Sadraee Arian , Nazmi Paria 
Published: December 2023

PurposeDespite the wide research and discussion on international performance, innovation and digital resilience dimensions of enterprises, the investigation and understanding of their interrelations seem to be limited. The purpose of this study is to identify the influential factors affecting the mentioned dimensions, determine the causal relationships among these identified factors and finally evaluate their importance in an aggregated framework from the viewpoint of small and medium-sized enterprises (SMEs).Design/methodology/approachA hybrid methodology is used to achieve the objectives. First, the main factors of international performance, innovation and digital resilience are extracted by an in-depth review of the literature. These factors are then screened by expert opinions to localize them in accordance with the conditions of an emerging economy. Finally, the relationship and the importance of the factors are determined using an uncertain multi-criteria decision-making (MCDM) approach.FindingsThe findings reveal that there is a correlation between digital resilience and innovation, and both factors have an impact on the international performance of SMEs. The cause-or-effect nature of the factors belonging to each dimension is also determined. Among the effect factors, business model innovation (BMI), agility, product and organizational innovation are known as the most important factors. International knowledge, personal drivers and digital transformation are also determined to be the most important cause factors.Originality/valueThis study extends the literature both in methodological and practical directions. Practically, the study aggregates the factors in the mentioned dimensions and provides insights into their cause-and-effect interrelations. Methodologically, the study proposes an uncertain MCDM approach that has been rarely used in previous studies in this field.
How perceived coolness and wow affect customer engagement: the role of self-image congruity
Authors: Liu Li-Ling , Teng Hsiu-Yu 
Published: December 2023

PurposeCustomer engagement has key practical implications for hospitality management. However, little is known about how perceived coolness and wow affect customer engagement. The purpose of this research was to investigate the associations among perceived coolness, perceived wow and customer engagement and examine the mediator of self-image congruity (SIC).Design/methodology/approachSurvey data were collected from 406 restaurant customers in Taiwan, and structural equation modeling was adopted to examine the hypotheses. Furthermore, a replica model was produced for another sample of 412 hotel customers.FindingsThe results indicate that perceived coolness positively affects customer engagement and SIC and that perceived wow positively affects SIC. SIC positively affects customer engagement. Moreover, SIC mediates the associations of perceived coolness and wow with customer engagement. The relationships between the variables did not significantly differ between restaurant customers and hotel customers.Practical implicationsHospitality businesses can create environments in which customers interact with service providers through innovative technology, thereby encouraging engagement. Coolness and the wow factor must be prioritized in servicescapes, meal and room design, the service process and creative marketing.Originality/valueThe findings contribute knowledge on hospitality, factors affecting customer engagement and the mediating mechanism of SIC. Hospitality managers can use the results to formulate strategies for servicescape design, brand management and customer experience.
Learning efficacy of understanding by design-Internet of Things (UbD-IoT) education integrated with design thinking and computational thinking
Authors: Lai Ying Hsun 
Published: December 2023

PurposeThe study integrated understanding by design-Internet of Things (UbD-IoT) education with design thinking and computational thinking to plan and design an IoT course. Cross-domain application examples were employed to train students in problem-understanding, deep thinking and logical design for IoT applications.Design/methodology/approachIn this study, the UbD model was integrated with design thinking and computational thinking in the planning and design of an IoT course. The examples of cross-domain applications were used to train students to understand a problem by engaging themselves in deep thinking and helping them think and design logically for an IoT application.FindingsThe UbD-IoT learning design greatly decreased students' overall cognitive load. UbD-IoT learning has a significant impact on the performance of computational thinking in problem-solving and problem-understanding. The impact of UbD-IoT learning on logical thinking and program learning cognition in students needs to be verified.Originality/valueThe results of this study have shown that the UbD model is effective in reducing the cognitive load of a learning course and also strengthens T-competencies in the lateral skills of computational thinking, critical problem-solving, logical thinking and creative thinking.