bluuebunny/crossref_metadata_2025_split huggingface dataset:
Comparison of Standard and Vacuum Specimen Mammography in the Detection of Margin Status in Conservative Surgery for Breast Cancer: a Cross-Sectional Diagnostic Study
Authors: Eslami Bita , Omranipour Ramesh , Bayani Leila , Seifollahi Akram , Saberi Azin , Jahanbin Behnaz , Zeinalkhani Fahimeh , Arian Arvin , Sefidabi Reyhaneh , Orouji Marzieh , Firoozsamadi Zohreh , Khosravi Hengame , Koopaee Soheila , Tavakol Mahsa , Alipour Sadaf 
Published: February 2024

Background: One of the most important factors that increases breast cancer (BC) recurrence after Breast-conserving surgery (BCS) is the positivity of the margins, which is found in permanent histological exams. Intra-operative specimen mammography (SM) can reduce the rate of margin positivity and re-operation. Our aim was to examine whether vacuum SM (VSM) is more accurate than standard SM (SSM) in detecting the positivity of the margins.
Methods: For this cross-sectional study, in the operating room, excised specimens of 55 women with breast cancer who underwent lumpectomy were oriented by metallic staples and sutures for radiologic and histological assessment, respectively. In the radiology ward, SSM was first taken; then, the specimen was vacuum packed and VSM was performed. Afterwards, the specimen was sent for histopathological analysis as a gold standard for the assessment of surgical margins. Specimens’ margins were classified according to the size of clear margins in millimeters as zero or >0; and ≤1 or >1.
Results: The mean age of all participants was 51.22 ± 10.58 years. Totally, 220 margins were assessed. According to classified margins (zero and 1 mm), for the detection of affected margins, the accuracy values of the VSM method were 90.52%, and 87.20% while these figures were 91.51% and 88.68% for SSM. There was substantial agreement between the two methods of detecting the affected margins (VSM and SSM), with Cohen's κ =0.66, 95% CI: 0.34-0.97, P-value <0.001). Finally, there was not a statistically significant difference in the proportion of detecting margin between SSM and VSM (McNemar test P-value =0.63).
Conclusion: Specimen mammography with an adequate orientation of the tissue is an accurate and practical method for immediate intraoperative examination of the margin status in BCS, and VSM is not superior to SSM in the detection of affected margins.
The Effect of Perceptions of Technology, Risk and Handling Complaints on Customer Interest in Using Internet Banking At Bank Syari'ah Indonesia (BSI) KC Kisaran
Authors: Khoiriaturrahmah Miftah , Anggraini Tuti , Jannah Nurul 
Published: February 2024

Bank Syari'ah Indonesia (BSI) is one of the companies that also utilizes information technology through digital services. Only not all digital services have many users, such as internet banking which is less than M-banking users. This study aims to determine the effect of perceived technology, risk and complaint handling on customer interest in using Internet banking at Bank Syariah Indonesia (BSI) Kisaran Branch Office. This research is a type of descriptive quantitative research. The population in this study were BSI customers at the Kisaran Branch Office. While the sample was obtained as many as 100 customers. Data collection techniques using questionnaires and documentation. The data analysis technique uses multiple regression analysis where before conducting multiple regression tests, classical assumption testing is carried out. The results of this study are Technology Perceptions, affecting customer interest in using Internet Banking at Bank Syariah Indonesia (BSI) Branch Office in Kisaran. Risk, affects customer interest in using Internet Banking at Bank Syari'ah Indonesia (BSI) Kisaran Branch Office. Handling Complaints, affects customer interest in using Internet Banking at Bank Syari'ah Indonesia (BSI),isaran Branch Office. The suggestion of this research is that it is hoped that the BSI Kisaran Branch Office will conduct broader socialization and promotion to further introduce the presence of Internet Bangking to potential customers.
Keywords: Technologi Perception, Risk, Complaint Handling, Customer Interest
Audio-Visual Therapy for Anxiety of Preoperative Patients Sectio Caesarea in the Central Surgical Installation Room of Ajibarang Hospital
Authors: Triana Noor Yunida , Haniyah Siti , A'yuni Qurrotul 
Published: February 2024

Sectio Caesarea (SC) is a surgical procedure in labor that can cause anxiety. These feelings can occur due to fear of death, failed medication and complications. One of the therapies to reduce anxiety of SC preoperative patients with audio-visual therapy. This study aims to determine the effect of audio-visual therapy on the anxiety of SC preoperative patients in the Central Surgical Installation Room (IBS) of Ajibarang Hospital. The study used quantitative methods with experimental design in the form of pre-experimental design one group pretest-posttest. The sample was mothers who will undergo SC in the IBS Room of Ajibarang Hospital, a total of 30 respondents with purposive sampling techniques. The research instrument used the APAIS questionnaire. Data were analyzed using the Wilcoxon test. The results of the study obtained a p value of 0.000 < 0.05, so it can be concluded that there are differences in the anxiety level of SC preoperative patients before and after audiovisual therapy in the IBS Room of Ajibarang Hospital. In conclusion, there are differences in the level of anxiety before and after audiovisual therapy is given to the anxiety level of SC preoperative patients in the IBS Room of Ajibarang Hospital.
A green and environmentally benign route to synthesizing Z-scheme Bi2S3-TCN photocatalyst for efficient hydrogen production
Authors: Yuan Lang , Yin Yihang , Xiang Peng , Shao Yugui , Gao Jie , Liu Jianan , Meng Huiyuan , Li Li , Xie Ying , Xiao Xudong , Jiang Baojiang 
Published: February 2024

Designing and developing photocatalysts with excellent performance in order to achieve efficient hydrogen production is an important strategy for addressing future energy and environmental challenges. Traditional single-phase photocatalytic materials either have a large bandgap and low visible light response or experience rapid recombination of the photogenerated carriers with low quantum efficiency, seriously hindering their photocatalytic applications. To solve these issues, an important solution is to construct well-matched heterojunctions with highly efficient charge separation capabilities. To this end, an in situ sulfurization reaction was adopted after the deposition of Bi3+ supramolecular complex on a layered supramolecular precursor of tubular carbon nitride (TCN). X-ray diffraction (XRD) patterns confirmed that the as-prepared sample has a good crystalline structure without any other impurities, while high-resolution transmission electron microscopy (HR-TEM) revealed that the heterojunction possesses a 2D structure with a layer of nano-array on its surface. Combined Fourier-transform infrared (FT-IR) spectra and energy-dispersive X-ray spectroscopy (EDX) revealed the interfacial interactions. Owing to the formation of the Z-scheme heterojunction, the visible light adsorption and the separation efficiency of the photo-generated carriers are both obviously enhanced, leaving the high energy electrons and high oxidative holes to participate in the photocatalytic reactions. As a result, the photocatalytic hydrogen evolution rate of Bi2S3-TCN achieves 65.2 μmol g-1·h-1. This proposed green and environmentally benign route can also be applied to construct other sulfides with 2D TCN, providing some important information for the design and optimization of novel carbon-nitride-based semiconductors.
Effect of tea intake on genetic predisposition to gout and uric acid: a Mendelian randomization study
Authors: Yu Yunfeng , Yang Xinyu , Hu Gang , Tong Keke , Yin Yuman , Yu Rong 
Published: February 2024

ObjectiveThe effect of tea on gout and uric acid is still controversial. This study aims to analyze the effect of tea intake on genetic predisposition to gout, idiopathic gout, gout due to impairment of renal function as well as uric acid by Mendelian randomization (MR).MethodsForty independent single nucleotide polymorphisms (SNPs) associated with tea intake were selected from UK Biobank. SNPs for uric acid were obtained from BioBank Japan, SNPs for gout were obtained from UK Biobank, and SNPs for gout due to impairment of renal function and idiopathic gout were derived from FinnGen. The causal relationship of exposure-outcome was tested using inverse variance weighted, MR-Egger and weighted median. MR-Egger intercept was employed to assess horizontal pleiotropy, Cochran’s Q test was used to assess heterogeneity, and leave-one-out sensitivity analysis was utilized to analyze the stability of the results.ResultsThe results of MR analysis showed that tea intake was negatively associated with gout due to impairment of renal function (OR 0.997, 95% CI 0.994 to 0.999, P = 0.017), whereas there was no causal association with gout, idiopathic gout, and uric acid (P &gt; 0.05), for which sensitivity analysis suggested that these results were robust.ConclusionsThere was a genetic predisposition effect of increased tea intake on the reduced risk of gout due to impairment of renal function, whereas there was no such effect on gout, idiopathic gout, and uric acid. Tea intake may become an important option in the dietary treatment of gout due to impairment of renal function.
Identification of potential therapeutic targets for COVID-19 through a structural-based similarity approach between SARS-CoV-2 and its human host proteins
Authors: Tasneem Alvea , Sultan Armiya , Singh Prithvi , Bairagya Hridoy R. , Almasoudi Hassan Hussain , Alhazmi Abdulfattah Yahya M. , Binshaya Abdulkarim S. , Hakami Mohammed Ageeli , Alotaibi Bader S. , Abdulaziz Eisa Alaa , Alolaiqy Abdulaziz Saleh I. , Hasan Mohammad Raghibul , Dev Kapil , Dohare Ravins 
Published: February 2024

Background: The COVID-19 pandemic caused by SARS-CoV-2 has led to millions of deaths worldwide, and vaccination efficacy has been decreasing with each lineage, necessitating the need for alternative antiviral therapies. Predicting host–virus protein–protein interactions (HV-PPIs) is essential for identifying potential host-targeting drug targets against SARS-CoV-2 infection.Objective: This study aims to identify therapeutic target proteins in humans that could act as virus–host-targeting drug targets against SARS-CoV-2 and study their interaction against antiviral inhibitors.Methods: A structure-based similarity approach was used to predict human proteins similar to SARS-CoV-2 (“hCoV-2”), followed by identifying PPIs between hCoV-2 and its target human proteins. Overlapping genes were identified between the protein-coding genes of the target and COVID-19-infected patient’s mRNA expression data. Pathway and Gene Ontology (GO) term analyses, the construction of PPI networks, and the detection of hub gene modules were performed. Structure-based virtual screening with antiviral compounds was performed to identify potential hits against target gene-encoded protein.Results: This study predicted 19,051 unique target human proteins that interact with hCoV-2, and compared to the microarray dataset, 1,120 target and infected group differentially expressed genes (TIG-DEGs) were identified. The significant pathway and GO enrichment analyses revealed the involvement of these genes in several biological processes and molecular functions. PPI network analysis identified a significant hub gene with maximum neighboring partners. Virtual screening analysis identified three potential antiviral compounds against the target gene-encoded protein.Conclusion: This study provides potential targets for host-targeting drug development against SARS-CoV-2 infection, and further experimental validation of the target protein is required for pharmaceutical intervention.
Mining of disease-resistance genes in Crocus sativus based on transcriptome sequencing
Authors: Ye Dongdong , Zhang Siwei , Gao Xiankui , Li Xiujuan , Jin Xin , Shi Min , Kai Guoyin , Zhou Wei 
Published: February 2024

Introduction:Crocus sativus L. has an important medicinal and economic value in traditional perennial Chinese medicine. However, due to its unique growth characteristics, during cultivation it is highly susceptible to disease. The absence of effective resistance genes restricts us to breed new resistant varieties of C. sativus.Methods: In present study, comprehensive transcriptome sequencing was introduced to explore the disease resistance of the candidate gene in healthy and corm rot-infected C. sativus.Results and discussion: Totally, 43.72 Gb of clean data was obtained from the assembly to generate 65,337 unigenes. By comparing the gene expression levels, 7,575 differentially expressed genes (DEGs) were primarily screened. A majority of the DEGs were completely in charge of defense and metabolism, and 152 of them were annotated as pathogen recognition genes (PRGs) based on the PGRdb dataset. The expression of some transcription factors including NAC, MYB, and WRKY members, changed significantly based on the dataset of transcriptome sequencing. Therefore, this study provides us some valuable information for exploring candidate genes involved in the disease resistance in C. sativus.
Correlation between inflammatory markers over time and disease severity in status epilepticus: a preliminary study
Authors: Shi Xiangsong , Zhang Xiulin , Song Sumeng , Pan Heyue , Huang Chengbing , Sun Taipeng , Wang Shouyong , Xu Jianyang 
Published: February 2024

ObjectivesConvulsive status epilepticus (CSE) is a major subtype of status epilepticus that is known to be closely associated with systemic inflammation. Some important inflammatory biomarkers of this disorder include the neutrophil-to-lymphocyte ratio (NLR), platelet-to-lymphocyte ratio (PLR), monocyte-to-lymphocyte ratio (MLR), systemic immune inflammation index (SII), and pan-immune inflammation value (PIV). This study aimed to determine the NLR, PLR, MLR, SII, and PIV levels before and after treatment in adult patients with CSE and investigated the relationship of these parameters with disease severity.MethodsThis retrospective study analyzed data from 103 adult patients with CSE and 103 healthy controls. The neutrophil, monocyte, platelet, and lymphocyte counts, as well as the NLR, PLR, MLR, SII, and PIV, were compared in adult patients with CSE during acute seizures (within 2 h of admission) and after treatment relief (1–2 weeks of complete seizure control). Furthermore, multivariate linear regression analysis investigated the relationship between NLR, PLR, MLR, SII, and PIV with the Status Epilepticus Severity Score (STESS).ResultsThe data revealed significant differences (p &lt; 0.05) in neutrophils, monocytes, lymphocytes, NLR, PLR, MLR, SII, and PIV between adult patients with CSE during acute seizures and after treatment relief. The average neutrophil count was high during acute seizures in the patient group and decreased after remission. In contrast, the average lymphocyte count was lower after remission (p &lt; 0.05). Furthermore, significant differences (p &lt; 0.05) were observed in monocytes, lymphocytes, platelets, NLR, PLR, MLR, and PIV levels between adult patients with CSE after remission and the healthy control group. Multivariate linear regression analysis showed no significant correlation between NLR, PLR, MLR, SII, and PIV with STESS.ConclusionThe results of this study indicated that adult patients with CSE experienced a transient systemic inflammatory response during acute seizures, which gradually returned to baseline levels after remission. However, there was a lack of robust clinical evidence correlating the severity of adult CSE and systemic inflammatory response.
Machine learning-based prediction of mild cognitive impairment among individuals with normal cognitive function
Authors: Zhu Xia Wei , Liu Si Bo , Ji Chen Hua , Liu Jin Jie , Huang Chao 
Published: February 2024

BackgroundPrevious studies mainly focused on risk factors in patients with mild cognitive impairment (MCI) or dementia. The aim of the study was to provide basis for preventing MCI in cognitive normal populations.MethodsThe data came from a longitudinal retrospective study involving individuals with brain magnetic resonance imaging scans, clinical visits, and cognitive assessment with interval of more than 3 years. Multiple machine-learning technologies, including random forest, support vector machine, logistic regression, eXtreme Gradient Boosting, and naïve Bayes, were used to establish a prediction model of a future risk of MCI through a combination of clinical and image variables.ResultsAmong these machine learning models; eXtreme Gradient Boosting (XGB) was the best classification model. The classification accuracy of clinical variables was 65.90%, of image variables was 79.54%, of a combination of clinical and image variables was 94.32%. The best result of the combination was an accuracy of 94.32%, a precision of 96.21%, and a recall of 93.08%. XGB with a combination of clinical and image variables had a potential prospect for the risk prediction of MCI. From clinical perspective, the degree of white matter hyperintensity (WMH), especially in the frontal lobe, and the control of systolic blood pressure (SBP) were the most important risk factor for the development of MCI.ConclusionThe best MCI classification results came from the XGB model with a combination of both clinical and imaging variables. The degree of WMH in the frontal lobe and SBP control were the most important variables in predicting MCI.
Experiences and perceptions of people with celiac disease, food allergies and food intolerance when dining out
Authors: Figueroa-Gómez Ximena , Oliveras-López María Jesus , Rodríguez Silva Juan Manuel , Poyanco Marcelo , López Herminia , Araya Magdalena 
Published: February 2024

IntroductionEating out is a common practice in modern society. Celiac disease (CeD) and food allergy (FA) are among the most common conditions responsible for adverse reactions to food. Despite their different origins, both require treatment with restrictive diets (avoidance of gluten and/or specific allergens) and this results posing similar challenges when eating out. Our objective was to learn about the experiences/perceptions of consumers with CeD and FA when dining out, as well as the challenges they face in food service environments.MethodsAn ad hoc questionnaire was used to record consumer perceptions, food service characteristics and resulting adverse reactions.Results377 individuals living in Santiago, Chile, provided complete information and were analyzed (160 CeD, 105 FA). 301 participants (79.8%) declared eating out, 33.6% reported experiencing an adverse reaction at least once while eating out. 94.4% of the 377 participants believed that the serving staff had little or no knowledge about his/her condition. Consumers reporting symptoms as severe adverse reactions were more common among celiac than allergic patients (p &lt; 0.001).DiscussionThe study showed no significant differences based on consumer-related characteristics (p:NS). The consequences of eating out did not vary based on individual’s data, including diagnosis, age, frequency of eating out, adverse reactions experienced, or intensity. These findings suggest that the most important determinants of risk associated with eating out are characteristics of the food service, like availability of information, staff training, and establishment’s facilities like equipment available, exclusive utensils for customers with special dietary needs and kitchen and bathrooms organization.
Trends of serum 25(OH) vitamin D and association with cardiovascular disease and all-cause mortality: from NHANES survey cycles 2001–2018
Authors: Hu Changlun , Yang Mei 
Published: February 2024

BackgroundThe focus of this survey is on survey data for adults aged 20 and above, covering nine survey cycles from 2001 to 2018. Additionally, the present study explored the correlation between vitamin D concentrations and both cardiovascular disease (CVD) and all-cause mortality.ObjectiveThe objectives of this study were to evaluate the trend of changes in the serum 25(OH)D concentration changes in US adults during the survey period, the prevalence of vitamin D deficiency, and the current status of vitamin D dietary intake and supplementation.MethodsIn-home health interviews were performed using meticulously designed questionnaires that gathered information on demographic details, socioeconomic conditions, dietary patterns, and overall health status. Health assessments were conducted in specially designed mobile centers.1ResultsSurvey data from 2001 to 2018 revealed a rise in serum 25(OH)D levels, from a weighted mean (95% CI) of 65.6 (63.8–67.4) nmol/L during 2001–2002 to 73.5 (70.4–76.5) nmol/L during 2017–2018, among US adults, while overall vitamin D deficiency rates remained stable (p = 0.152). Notably, in adults aged 20–39, 25(OH)D levels decreased (p = 0.002 for trend), and 25(OH)D deficiency increased (p = 0.003 for trend), especially among those with low incomes (deficiency &gt;30%). Upon multivariable adjustment, an L-shaped relationship was found between serum 25(OH)D concentrations and both CVD and all-cause mortality (p &lt; 0.001 for nonlinearity), as corroborated by sensitivity analyses.ConclusionFrom 2001 to 2018, US adults experienced a significant increase in their serum 25(OH) D concentration. However, subgroups of individuals, including young adults and individuals with lower socioeconomic status, exhibited a heightened risk of 25(OH)D deficiency. Furthermore, an L-shaped relationship was found between 25(OH)D concentration and both all-cause and CVD mortality among US adults.