bluuebunny/crossref_metadata_2025_split huggingface dataset:
IVIVC assessment, pharmacokinetic evaluation, and X-ray radiography mapping of Novel Parteck® SRP 80 and hypromellose-loaded LTD4 receptor antagonist chronosystem
Authors: Jawed Saniya , Satish C. S. 
Published: November 2023

Abstract
Background
The current research aims to determine the pharmacokinetic parameters, mucoadhesive strength, and IVIVC correlation of the novel chronotherapeutic drug delivery system of montelukast sodium (MTS) loaded Parteck® SRP80 and hypromellose system. To accomplish this, an HPLC method was developed which is highly sensitive, precise, and rapid for quantifying pure MTS in rabbit plasma. Mucoadhesive strength and time-dependent mobility of developed formulation were established by ex-vivo study and X-ray radiography, respectively. Using a fraction of drug absorbed (FDA) and a fraction of drug released (FDR), Level-A in-vitro in-vivo correlation (IVIVC) was developed. According to ICH Q1A (R2) standards, stability experiments were conducted for 180 days.

Result
MTS retention time came as 3.971 min with a mobile phase of methanol: acetonitrile: 0.2 mM sodium acetate buffer (5:90:5). In-vitro dissolution showed pulsatile release of the drug up to 24 h with two lag phases. The in-vivo study showed a Cmax of 490.16 ± 33.95 ng/ml, Tmax of 9 h, and MRT of 14.08 ± 1.21 h. The correlation coefficient of 0.9899 confirmed the level-A IVIVC. Uncoated matrix tablet of Parteck® SRP 80 displayed mucoadhesive strength 1.25-fold higher than hypromellose. Stability experiments found no significant changes in drug content, physical appearance, and cumulative percentage release with a similarity factor of 87–90.

Conclusion
A single oral dose in-vivo study proved the sustained release of the drug for 24 h with satisfactory mucoadhesive strength. Moreover, X-ray radiography has confirmed the time-dependent presence of formulation at the needed spot. This study fulfilled all the requirements for chronotherapy of asthma and can be scaled up in the future.

Graphical abstract
Exploration of the aptitude to alleviate oxidative impairment and curb colorectal cancer manifestation by Nostoc calcicola in HT-29 adenocarcinoma cells
Authors: Gupta Pragati , Khader Syed Zameer Ahmed , Syed Zameer Ahmed Sidhra , Kaliyannan Rajavel Abithaa , Sawant Sameer , Manickam Paulpandian 
Published: November 2023

Abstract
Background
Marine cyanobacteria have been known to contain several unique bioactive compounds which have different therapeutic potentials. The current research focuses to identify the efficacy of Nostoc calcicola to counteract the harmful effects of free radicals and testing its anticancer activity against colorectal adenocarcinoma cells (HT-29).

Results
Methanol is used as a solvent for the extraction of bioactive metabolites from Nostoc calcicola followed by phytochemical screening representing the presence of flavonoids, phenols, tannins, saponins, and steroids to find out bioactive metabolites. Furthermore, evaluation of the extract efficacy revealed the profound ability of Nostoc calcicola to scavenge free radicals by neutralizing different reactive oxygen species. At 100 µg/mL concentration, it inhibited DPPH radicals (73.4%), enhanced phosphomolybdenum reduction (53.5%), displayed ferric-reducing power (55.1%), and finally the extract revealed remarkable hydroxyl radicals scavenging capacity (94.8%), compared to the standards. These compelling results emphasize the robust antioxidant potential of the Nostoc calcicola extract. In vitro, studies demonstrated the selective cytotoxic effects of methanol extracts of Nostoc calcicola on the HT-29 human colorectal cancer cell line, as indicated by IC50 values of 25 µg/mL for the extracts. Treatment with me Nostoc calcicola decreased the cell viability of HT-29 cells followed by consistent morphological changes leading to cytotoxicity. Nuclear condensation and DNA fragmentation were observed using AO/EtBr and DAPI staining. Flow cytometry analysis further confirmed the incidence of apoptosis during the S phase of the cell cycle. Furthermore, western blotting analysis confirmed the activation of caspase 9, a pivotal enzyme in the intrinsic apoptosis pathway, suggesting the ability of Nostoc calcicola to induce apoptosis in HT-29 colorectal cancer cells.

Conclusion
These findings underscore the potential of Nostoc calcicola as a valuable source of bioactive compounds with antioxidant and anticancer properties, warranting further investigation for their potential therapeutic applications in colorectal cancer.

Graphical Abstract
Clinical features and 28-day mortality predictors of vaccinated patients admitted to a COVID-19 ICU hub in Italy
Authors: Stella Claudia , Berardi Cecilia , Chiarito Annalisa , Gennenzi Veronica , Postorino Stefania , Settanni Donatella , Cesarano Melania , Xhemalaj Rikardo , Tanzarella Eloisa Sofia , Cutuli Salvatore Lucio , Grieco Domenico Luca , Conti Giorgio , Antonelli Massimo , De Pascale Gennaro 
Published: November 2023

Abstract
Background
COVID-19 vaccination has been proved to be effective in preventing hospitalization and illness progression, even though data on mortality of vaccinated patients in the intensive care unit (ICU) are conflicting. The aim of this study was to investigate the characteristics of vaccinated patients admitted to ICU according to their immunization cycle and to outline the risk factors for 28-day mortality. This observational study included adult patients admitted to ICU for acute respiratory failure (ARF) due to SARS-CoV-2 and who had received at least one dose of vaccine.

Results
Fully vaccination was defined as a complete primary cycle from < 120 days or a booster dose from > 14 days. All the other patients were named partially vaccinated. One-hundred sixty patients (91 fully and 69 partially vaccinated) resulted eligible, showing a 28-day mortality rate of 51.9%. Compared to partially vaccinated, fully vaccinated were younger (69 [60–77.5] vs. 74 [66–79] years, p 0.029), more frequently immunocompromised (39.56% vs. 14.39%, p 0.003), and affected by at least one comorbidity (90.11% vs 78.26%, p 0.045), mainly chronic kidney disease (CKD) (36.26% vs 20.29%, p 0.035). At multivariable analysis, independent predictors of 28-day mortality were as follows: older age [OR 1.05 (CI 95% 1.01–1.08), p 0.005], history of chronic obstructive pulmonary disease (COPD) [OR 3.05 (CI 95% 1.28–7.30), p 0.012], immunosuppression [OR 3.70 (CI 95% 1.63–8.40), p 0.002], and admission respiratory and hemodynamic status [PaO2/FiO2 and septic shock: OR 0.99 (CI 95% 0.98–0.99), p 0.009 and 2.74 (CI 95% 1.16–6.48), p 0.022, respectively].

Conclusions
Despite a full vaccination cycle, severe COVID-19 may occur in patients with relevant comorbidities, especially immunosuppression and CKD. Regardless the immunization status, predisposing conditions (i.e., older age, COPD, and immunosuppression) and a severe clinical presentation were predictors of 28-day mortality.
Wellbeing, loneliness, health-related quality of life and perception of technology of older adults in Slovenian senior homes: a cross-sectional study
Authors: Lipovac Dean , Erce Mateja 
Published: November 2023

Background: Older adults can experience loneliness, low wellbeing, and poor health, while certain technologies could alleviate some of these issues. This paper presents findings from a study conducted in Slovenian senior homes, examining the wellbeing, loneliness, health-related quality of life, and perceptions of technology among older adults without significant cognitive issues. Methods: Older adults (n = 73) responded to questionnaires on wellbeing, loneliness, and health-related quality of life. They also provided their opinion on four different types of technology: a smartphone (SeniorsPhone) and television-based video calling system adapted to older adults (Daisy), a smartwatch (Fitbit), and an air quality sensor. Results: The results indicate that most examined older adults experience low or moderate levels of loneliness, and most are characterized by average or high levels of wellbeing. The participants also report no significant issues with self-care and accomplishing daily activities. However, more than half of the participants report experiencing some problems with pain/discomfort and mobility. Older adults generally trust evaluated technologies with their personal data, believe that the technologies provide reliable information, and perceive technologies as useful. Interestingly, older adults that reported higher levels of wellbeing and lower levels of loneliness tended to perceive the smartwatch as more usable. This suggests that at least for some technologies, the perception of usability depends on how people feel in general. Conclusions: Residents of Slovenian senior homes that do not have significant cognitive issues report relatively high wellbeing and health-related quality of life and low loneliness, together with positive perceptions of different technologies. These findings can be used to inform the development of age-appropriate technologies for senior home residents.
Follicular cholangitis: a rare cause of benign biliary stricture
Authors: Lampropoulou Virginia , Sioulas Athanasios , Papadaki Konstantina , Pagkratis Spyridon , Papaioannou Dimitrios , Tzimas George , Scotiniotis Ilias 
Published: November 2023

Introduction: The differential diagnosis of focal biliary strictures comprises both malignant and benign conditions. We report a rare case of follicular cholangitis presenting with segmental stricture of the left hepatic duct. Case description: An asymptomatic 59-year-old male with no past medical history presented with dilation of the left intrahepatic bile ducts revealed as an incidental finding on an abdominal ultrasound. Blood examinations showed only a slightly elevated gamma- glutamyl transferase (gammaGT) value, while carbohydrate antigen 19-9 (Ca 19-9) and serum immunoglobulin G4 (IgG4) were within normal range. Abdominal computed tomography and magnetic resonance imaging/magnetic resonance cholangiopancreatography (MRI/MRCP) scans revealed a high grade focal intrahepatic stricture of the left hepatic duct (FIHS type III) with proximal dilatation. Given that a diagnosis of cholangiocarcinoma could not be ruled out, the patient was referred for a left hepatectomy with regional lymph node dissection. Histological analysis showed a lymphoplasmacytic infiltration of the left hepatic duct with fibrosis and follicle formations in the submucosa, findings consistent with follicular cholangitis. The postoperative course was uneventful and there is no evidence of recurrence 8 months after the surgery. Discussion: The clinical and imaging presentation of follicular cholangitis is very similar to cholangiocarcinoma, rendering it a challenging diagnosis preoperatively. Conclusion: The approach to these cases should be primarily surgical. Even though it is very rare -- our report is the 13th case reported worldwide -- follicular cholangitis should be included in the differential diagnosis of focal biliary strictures.
Self-powered photodetector based on a CsPbBr3/n-Si Schottky junction
Authors: Hua Feng , Du Xin , Huang Zhenyu , Gu Yiting , Wen Jianfeng , Liu Fuchi , Chen Junxue , Tang Tao 
Published: November 2023

Self-powered photodetectors (SPPDs) are attracting considerable publicity due to their superiority over conventional photodetectors (PDs) in terms of high sensitivity, fast response, and no need for an external power supply. Halide perovskites are much anticipated in SPPDs for their unusual photoelectronic properties. This work developed a Schottky junction CsPbBr3/n-Si SPPD by growing stable all-inorganic CsPbBr3 microcrystals on an n-Si substrate using a solution method. At zero bias, such Schottky SPPD has a very weak dark current (0.3 pA), a wide linear dynamic range (LDR, 110 dB), a sizeable on–off ratio (>103), and high detectivity (1.05×1011Jones). Through the research of this project, it is expected to obtain a way to prepare Schottky photodiodes with high stability and self-driving capability.
Public-private partnerships influencing the initiation and duration of clinical trials for neglected tropical diseases
Authors: Ma Zhongxuan , Augustijn Kevin , De Esch Iwan , Bossink Bart 
Published: November 2023

Public-private partnerships (PPPs) for neglected tropical diseases (NTDs) are often studied as an organizational form that facilitates the management and control of the huge costs of drug research and development. Especially the later stages of drug development, including clinical trials, become very expensive. This present study investigates whether and how the type of PPPs influences the initiation and duration of NTD clinical trials. Using the ClinicalTrials.gov database, a dataset of 1175 NTD clinical studies that started between 2000 and 2021 is analyzed based on affiliation information and project duration. For the NTD clinical trials that resulted from PPPs, the collaborating types were determined and analyzed, including the public sector-, private sector-, governmental sector-, and nongovernmental organization-led collaborations. The determinants for the discontinuation of all stopped clinical trials were categorized into scientific-, funding-, political-, and logistic dimensions. The results reveal that public sector-led PPPs were the most common collaborative types, and logistic and scientific issues were the most frequent determinants of stopped clinical trials.
Trial registration: ClinicalTrials.gov.
Using a behavior change toolkit in pediatric physical therapy to support physical activity: A feasibility study
Authors: Sol Marleen E. , Kotte Elles M. W. , Bolster Eline A. M. , Hermsen Sander , van der Lugt Remco , Elbers Stefan , Sanders Margreet , Bloemen Manon A. T. 
Published: November 2023

Introduction
Physical activity levels of children with disabilities are low, as these children and their parents face a wide variety of both personal and environmental barriers. Behavior change techniques support pediatric physical therapists to address these barriers together with parents and children. We developed the What Moves You?! intervention Toolkit (WMY Toolkit) filled with behavioral change tools for use in pediatric physical therapy practice.

Objective
To evaluate the feasibility of using the WMY Toolkit in daily pediatric physical therapy practice.

Methods
We conducted a feasibility study with a qualitative approach using semi-structured interviews with pediatric physical therapists (n = 11). After one day of training, the pediatric physical therapists used the WMY Toolkit for a period of 9 weeks, when facilitating physical activity in children with disabilities. We analyzed the transcripts using an inductive thematic analysis followed by a deductive analysis using a feasibility framework.

Results
For acceptability, pediatric physical therapists found that the toolkit facilitated conversation about physical activity in a creative and playful manner. The working mechanisms identified were in line with the intended working mechanisms during development of the WMY Toolkit, such as focusing on problem solving, self-efficacy and independence. For demand, the pediatric physical therapists mentioned that they were able to use the WMY Toolkit in children with and without disabilities with a broad range of physical activity goals. For implementation, education is important as pediatric physical therapists expressed the need to have sufficient knowledge and to feel confident using the toolkit. For practicality, pediatric physical therapists were positive about the ease of which tools could be adapted for individual children. Some of the design and materials of the toolkit needed attention due to fragility and hygiene.

Conclusion
The WMY Toolkit is a promising and innovative way to integrate behavior change techniques into pediatric physical therapy practice.
Understanding suicidal ideation–a network analysis of the Interpersonal Needs Questionnaire
Authors: Conrad Katharina , Forkmann Thomas , Schreiber Dajana , Teismann Tobias , Glaesmer Heide , Spangenberg Lena , Schönfelder Antje , Hallensleben Nina , Paashaus Laura , Juckel Georg , Höller Inken 
Published: November 2023

Introduction
Identifying various interacting risk factors for suicidality is important to develop preventive measures. The Interpersonal-Psychological Theory of Suicidal Behavior (IPTS) postulates suicidal ideation resulting from the occurrence of Perceived Burdensomeness (PB) and Thwarted Belongingness (TB). Suicidal behavior ultimately occurs if people have a Capability for Suicide. In past studies, the validity of TB was often not empirically confirmed, questioning which of the aspects of TB are central and related to suicidal ideation and whether applied measurement methods adequately capture the construct.

Method
Using a sample of 3,404 individuals from different clinical and nonclinical settings, 30% (1,023) of whom reported suicidal ideation, two network analyses were conducted on the Interpersonal Needs Questionnaire (INQ) and a variable mapping suicidal ideation.

Results
Analyses revealed that some items of the INQ were not related to suicidal ideation and the most central items did not have the strongest associations to suicidal ideation.

Conclusion
Based on these results, a shortened version of the INQ with the four items that showed the strongest associations with suicidal ideation in the network analyses was suggested.
Isometric versus isotonic exercise in individuals with rotator cuff tendinopathy—Effects on shoulder pain, functioning, muscle strength, and electromyographic activity: A protocol for randomized clinical trial
Authors: Rodrigues da Silva Barros Bianca , Dal’Ava Augusto Denise , de Medeiros Neto João Felipe , Michener Lori Ann , Silva Rodrigo Scattone , Sousa Catarina de Oliveira 
Published: November 2023

Introduction
Rotator cuff tendinopathy is a common shoulder disorder in which the primary treatment is resistance exercises. Isometric exercises are being studied for lower limb tendinopathies but not for rotator cuff tendinopathy. This protocol for a randomized clinical trial aims to compare the effects of two types of exercise (isometric and isotonic) on shoulder pain, functioning, muscle strength, and electromyographic activity in individuals with rotator cuff tendinopathy.

Methods
Forty-six individuals (18 to 60 years old) with shoulder pain for more than three months and unilateral supraspinatus and/or infraspinatus tendinopathy will participate in this trial. Individuals will be randomized into two exercise groups: isometric or isotonic. The following outcomes will be evaluated before and after the first session and after six weeks of intervention: shoulder pain and functioning; isometric strength of shoulder elevation and lateral and medial rotation; and electromyographic activity of medial deltoid, infraspinatus, serratus anterior, and lower trapezius. Groups will perform stretching and strengthening of periscapular muscles. The isometric group will perform three sets of 32 s, at 70% of maximal isometric strength. The isotonic group will perform concentric and eccentric exercises (2 s for each phase) in three sets of eight repetitions at a load of eight repetition maximum. The total time under tension of 96 s will be equal for both groups, and load will be adjusted in weeks three and five of the protocol. Treatment effect between groups will be analyzed using linear mixed model.

Trial registration
Trial registration number: Universal Trial Number (UTN) code U1111-1284-7528 and Brazilian Clinical Trials Registry platform–RBR-3pvdvfk.
Women’s socioeconomic status and attitudes toward intimate partner violence in Eswatini: A multilevel analysis
Authors: Chemhaka Garikayi B. , Moyo Stanzia , Simelane Maswati S. , Odimegwu Clifford 
Published: November 2023

Introduction
Attitudes supportive of spousal violence retards developmental efforts worldwide, and in particular in patriarchal African settings. It is important to curb this behavior by designing preventative evidence-based policies. This study examines the acceptance of intimate partner violence among women residing in Eswatini and determines whether attitudes supportive of intimate partner violence are associated with women’s low socioeconomic status both at the individual- and community-level.

Methods
Cross-sectional secondary data from two Eswatini Multiple Indicator Cluster Surveys (MICS) conducted in 2010 and 2014 with representative samples of 4,686 and 4,761 women, respectively were analyzed using descriptive statistics and multilevel (random effect) logistic regressions.

Results
Overall, the prevalence of acceptance of intimate partner violence declined significantly between 2010 and 2014 in Eswatini (29.0% vs. 19.8%, p<0.001). In both surveys, socioeconomic factors associated with women’s supportive attitudes toward intimate partner violence were educational level, marital structure, and community socioeconomic disadvantage. Overall, primary or lower educational attainment, single/unmarried relationships, and women living in a community with a high socioeconomic disadvantage were key factors associated with supportive attitudes toward intimate partner violence.

Conclusions
Secondary or higher education for individual women and a high proportion of women in the community with low socioeconomic disadvantage are important socioeconomic predictors of reducing women’s supportive attitudes toward intimate partner violence. Therefore, further gains in non-supportive attitudes toward acceptance of intimate partner violence could be achieved through efforts and intervention in the education of individual women and improving women’s socioeconomic status in the community.
Late Jurassic Haobugao granites from the southern Great Xing’an Range, NE China: Implications for postcollision extension of the Mongol–Okhotsk Ocean
Authors: Li Jianda , Tian Yue , Cheng Yuqi 
Published: November 2023

Abstract
The Mongolia-Okhotsk tectonic regime had a significant impact on the tectonic evolution of Northeastern (NE) China. However, there is no consensus on the role of this regime in the geological evolution of the Xing’an Massif during the late Mesozoic. This article presents the results of zircon U–Pb geochronology, whole-rock major and trace-element geochemistry, and zircon Hf isotopic compositions for granites in the Haobugao area of the southern Great Xing’an Range, NE China, to determine their petrogenesis, source, and tectonic setting. The zircon U–Pb ages indicate that the granites crystallized at 152.7 ± 0.5 Ma. The granites exhibit high SiO2 (70.75–73.19 wt%) and K2O + Na2O (8.00–8.65 wt%) contents and extremely low MgO (0.40–0.59 wt%) and TiO2 (0.24–0.33 wt%) contents. They belong to the metaluminous, high-K calc-alkaline, and ferroan series, with mostly right-inclined REE curves, flat heavy rare earth element patterns, high 10,000 Ga/Al ratios, and intensely negative Eu anomalies. The Zr/Hf ratios are 24.2–27.7, Nb/Ta ratios are 6.4–8.9, and Y/NbN ratios are >1.2. These characteristics suggest an A2-type granite affinity. The zircon εHf values of the rocks range from +5.62 to +9.12, corresponding to T
DM2 values of 621–906 Ma, indicating that juvenile materials in the Neoproterozoic may be a source of these granites. Geochemically, these Late Jurassic A2-type granites are similar to those from post-collision extension settings. The primary magma was likely derived from the partial melting of a delaminated region of the lower crust.