bluuebunny/crossref_metadata_2025_split huggingface dataset:
DELFOS—drug efficacy leveraging forked and specialized networks—benchmarking scRNA-seq data in multi-omics-based prediction of cancer sensitivity
Authors: Piochi Luiz Felipe , Preto António J , Moreira Irina S 
Published: October 2023

Abstract

Motivation
Cancer is currently one of the most notorious diseases, with over 1 million deaths in the European Union alone in 2022. As each tumor can be composed of diverse cell types with distinct genotypes, cancer cells can acquire resistance to different compounds. Moreover, anticancer drugs can display severe side effects, compromising patient well-being. Therefore, novel strategies for identifying the optimal set of compounds to treat each tumor have become an important research topic in recent decades.

Results
To address this challenge, we developed a novel drug response prediction algorithm called Drug Efficacy Leveraging Forked and Specialized networks (DELFOS). Our model learns from multi-omics data from over 65 cancer cell lines, as well as structural data from over 200 compounds, for the prediction of drug sensitivity. We also evaluated the benefits of incorporating single-cell expression data to predict drug response. DELFOS was validated using datasets with unseen cell lines or drugs and compared with other state-of-the-art algorithms, achieving a high prediction performance on several correlation and error metrics. Overall, DELFOS can effectively leverage multi-omics data for the prediction of drug responses in thousands of drug–cell line pairs.

Availability and implementation
The DELFOS pipeline and associated data are available at github.com/MoreiraLAB/delfos.
Imaging in patients with cardiovascular implantable electronic devices: part 2—imaging after device implantation. A clinical consensus statement of the European Association of Cardiovascular Imaging (EACVI) and the European Heart Rhythm Association (EHRA) of the ESC
Authors: Stankovic Ivan , Voigt Jens-Uwe , Burri Haran , Muraru Denisa , Sade Leyla Elif , Haugaa Kristina Hermann , Lumens Joost , Biffi Mauro , Dacher Jean-Nicolas , Marsan Nina Ajmone , Bakelants Elise , Manisty Charlotte , Dweck Marc R , Smiseth Otto A , Donal Erwan ,   Reviewers: This document was reviewed by members of the 2020–2022 EACVI Scientific Documents Committee:, Andreini Daniele , Bäck Magnus , Bertrand Philippe B , Keenan Niall , Neglia Danilo ,   by the 2020–2022 EACVI President:, Cosyns Bernard 
Published: October 2023

Abstract
Cardiac implantable electronic devices (CIEDs) improve quality of life and prolong survival, but there are additional considerations for cardiovascular imaging after implantation—both for standard indications and for diagnosing and guiding management of device-related complications. This clinical consensus statement (part 2) from the European Association of Cardiovascular Imaging, in collaboration with the European Heart Rhythm Association, provides comprehensive, up-to-date, and evidence-based guidance to cardiologists, cardiac imagers, and pacing specialists regarding the use of imaging in patients after implantation of conventional pacemakers, cardioverter defibrillators, and cardiac resynchronization therapy (CRT) devices. The document summarizes the existing evidence regarding the role and optimal use of various cardiac imaging modalities in patients with suspected CIED-related complications and also discusses CRT optimization, the safety of magnetic resonance imaging in CIED carriers, and describes the role of chest radiography in assessing CIED type, position, and complications. The role of imaging before and during CIED implantation is discussed in a companion document (part 1).
Antiarrhythmic effects of baroreceptor activation therapy in chronic heart failure: a case report
Authors: Wang Dong , Veltmann Christian , Bauersachs Johann , Duncker David 
Published: October 2023

Abstract

Background
Autonomic imbalance represents a keystone of chronic heart failure (HF) with substantial clinical and prognostic implications. Baroreceptor activation therapy (BAT) is a new therapeutic strategy to target the autonomic dysbalance by electrical stimulation of carotid baroreceptors. Besides its known beneficial effects on HF parameters, BAT is also supposed to trigger potential antiarrhythmic effects, which may additionally contribute to HF improvement.

Case summary
We report on a 70-year-old male with progredient shortness of breath and advanced HF in the context of an extensive cardiovascular history. After optimization of pharmacologic and device-related therapy, the decision was made to implant a BAT system (Barostim Neo, CVRx) to improve functional cardiac parameters and support symptomatic improvement. Implantation was associated with an overall clinical improvement assessed during outpatient visits every 6 months. Frequency of ventricular arrhythmic events declined, and atrial fibrillation ceased spontaneously. Echocardiography revealed an amelioration in left ventricular systolic function. Numbers of HF hospitalization decreased after Barostim implantation.

Discussion
We present a patient with an extensive cardiovascular history and fully exploited pharmacologic and device-related therapy, who showed improvement in New York Heart Association (NYHA) functional classification, left ventricular systolic function, and reduction of arrhythmic events following implantation of the BAT device. This case presents an additional positive potential of BAT for HF patients in terms of reduction of arrhythmia burden. These results should be confirmed by further clinical trials.
Healthy sleep score changes and incident cardiovascular disease in European prospective community-based cohorts
Authors: Nambiema Aboubakari , Lisan Quentin , Vaucher Julien , Perier Marie-Cecile , Boutouyrie Pierre , Danchin Nicolas , Thomas Frédérique , Guibout Catherine , Solelhac Geoffroy , Heinzer Raphael , Jouven Xavier , Marques-Vidal Pedro , Empana Jean-Philippe 
Published: October 2023

Abstract

Background and Aims
Evidence on the link between sleep patterns and cardiovascular diseases (CVDs) in the community essentially relies on studies that investigated one single sleep pattern at one point in time. This study examined the joint effect of five sleep patterns at two time points with incident CVD events.

Methods
By combining the data from two prospective studies, the Paris Prospective Study III (Paris, France) and the CoLaus|PsyCoLaus study (Lausanne, Switzerland), a healthy sleep score (HSS, range 0–5) combining five sleep patterns (early chronotype, sleep duration of 7–8 h/day, never/rarely insomnia, no sleep apnoea, and no excessive daytime sleepiness) was calculated at baseline and follow-up.

Results
The study sample included 11 347 CVD-free participants aged 53–64 years (44.6% women). During a median follow-up of 8.9 years [interquartile range (IQR): 8.0–10.0], 499 first CVD events occurred (339 coronary heart disease (CHD) and 175 stroke). In multivariate Cox analysis, the risk of CVD decreased by 18% [hazard ratio (HR) 0.82, 95% confidence interval (CI) 0.76–0.89] per one-point increment in the HSS. After a median follow-up of 6.0 years (IQR: 4.0–8.0) after the second follow-up, 262 first CVD events occurred including 194 CHD and 72 stroke. After adjusting for baseline HSS and covariates, the risk of CVD decreased by 16% (HR 0.84, 95% CI 0.73–0.97) per unit higher in the follow-up HSS over 2–5 years.

Conclusions
Higher HSS and HSS improvement over time are associated with a lower risk of CHD and stroke in the community.
Adjudication of Procedural Safeguards for Vulnerable Asylum Seekers in Greece: Case Law and Systemic Non-Compliance
Authors: Mouzourakis Minos 
Published: October 2023

Abstract
Special procedural guarantees for vulnerable asylum seekers are a core part of refugee status determination standards. These safeguards are neither afforded, nor properly adjudicated in Greek asylum procedures, however. Drawing on recent case law, this article argues that Greek appeal bodies (the Appeals Committees) routinely rule that vulnerability is irrelevant to refugee status determination or that no procedural harm is sustained from the inappropriate channelling of vulnerable people into truncated procedures, in dereliction of European Union (EU) standards and domestic jurisprudence. Systemic non-compliance with the duty to grant special procedural safeguards is a policy choice, yet the European Commission, the institution responsible for EU law enforcement, refrains from enforcing these standards in Greece. The Commission’s enforcement deficit vis-à-vis the Greek asylum system is underpinned by its Task Force for Migration Management’s prioritization of ending overcrowding and speeding up decision making over procedural standards, as well as an uneasy balancing act between operational support and monitoring.
Changing Epidemiology and Outcome of Pediatric Thermal Burn Injury in South Western Nigeria
Authors: Olawoye Olayinka Adebanji , Isamah Chinsunum Peace , Ademola Samuel Adesina , Iyun Ayodele Olukayode , Michael Afieharo Igbibia , Aderibigbe Rotimi Opeyemi , Oluwatosin Odunayo Moronfoluwa 
Published: October 2023

Abstract
The pediatric age group has been noted to be particularly vulnerable to burn injuries. Burn is the fifth most common cause of childhood injuries. Nigeria has a very young population with a median age of 18.1 years. Scald is the most common form of burn injuries in this age group globally; however, previous reports from our institution found flame to be the most common form of burn in pediatric age. The most recent report from 13 years ago still maintained flame as the most common cause of pediatric burn injury. This study was carried out to determine the changes in epidemiology and outcome of pediatric thermal burn injury. This was a retrospective study carried out between January 2013 and December 2022. Data were analyzed using the statistical package for social sciences software version 23. The significance was set at a P-value of .05. Two hundred and sixty-five children presented with thermal burn with a male-to-female ratio of 1.3:1. 63.4% occurred in children 0-5 years. Scald (59.6%) was the most common cause of injury. Most flame injuries in females were due to liquified petroleum gas cookstove explosion, while petrol explosion was the most common cause in males (P ≤ .001). There is a yearly increase in burn depth (P = .009). Most inhalation injuries occurred in those aged 11–16 years (P = .006). Mortality rate was 10.2%, with total body surface area burned (P ≤ .001), burn depth (P ≤ .001), and inhalation injury (P ≤ .001) associated with increasing mortality. Scald is now the most common cause of thermal burn in our institution, with a remarkable reduction in mortality rate.
Rare malignant neoplasm of the esophagus: current status and future perspectives
Authors: Yoshinami Yuri , Nishimura Erica , Hosokai Taisuke , Yamamoto Shun , Matsuda Satoru , Nomura Motoo , Kawakubo Hirofumi , Kato Ken , Kitagawa Yuko 
Published: October 2023

Abstract
Esophageal cancer is common worldwide, including in Japan, and its major histological subtype is squamous cell carcinoma. However, there are some rare esophageal cancers, including neuroendocrine neoplasm, gastrointestinal stromal tumor, carcinosarcoma and malignant melanoma. The biological and clinical features of these cancers differ from those of esophageal squamous cell carcinoma. Therefore, different treatment strategies are needed for these cancers but are based on limited evidence. Neuroendocrine neoplasm is mainly divided into neuroendocrine tumor and neuroendocrine carcinoma by differentiation and the Ki-67 proliferation index or mitotic index. Epidemiologically, the majority of esophageal neuroendocrine neoplasms are neuroendocrine carcinoma. The treatment of neuroendocrine carcinoma is similar to that of small cell lung cancer, which has similar morphological and biological features. Gastrointestinal stromal tumor is known to be associated with alterations in the c-KIT and platelet-derived growth factor receptor genes and, if resectable, is treated in accordance with the modified Fletcher classification. Carcinosarcoma is generally resistant to both chemotherapy and radiotherapy and requires multimodal treatments such as surgery plus chemotherapy to achieve cure. Primary malignant melanoma is resistant to cytotoxic chemotherapy, but immune checkpoint inhibitors have recently demonstrated efficacy for malignant melanoma of the esophagus. This review focuses on the current status and future perspectives for rare cancer of the esophagus.
Snowshoe hare virus: discovery, distribution, vector and host associations, and medical significance
Authors: Walker Edward D , Yuill Thomas M 
Published: October 2023

Abstract
Snowshoe hare virus (SSHV), within the California serogroup of the genus Orthobunyavirus, family Peribunyaviridae, was first isolated from a snowshoe hare (Lepus americanus) in Montana, United States, in 1959. The virus, closely related to LaCrosse virus (LACV) and Chatanga virus (CHATV), occurs across Canada and the northern latitudes of the United States, primarily in the northern tier of states bordering Canada. Reports of SSHV in northern Europe and Asia are probably the closely related to CHATV, or the less closely related Tahyna virus. Vertebrate associations include snowshoe hares and ground squirrels, demonstrated by field isolation of virus from wild-caught animals, seroconversion of snowshoe hares, seroconversion of sentinel rabbits, isolation of virus from sentinel rabbits, and experimental infections demonstrating viremia. Isolations of virus from field populations of mosquitoes include primarily univoltine and boreal mosquitoes of the genus Aedes, Culiseta impatiens and Culiseta inornata; and, rarely, certain multivoltine floodwater Aedes species. Experimental transmission studies in mosquitoes show infection in and transmission by boreal Aedes and Culiseta inornata. Isolation of SSHV from larval Aedes on three occasions, and experimentation in Culiseta inornata, reveal transovarial transmission of the virus in mosquitoes. Serosurveys reveal exposure to SSHV in human and domestic animals, with rates of seropositivity commonly high in some settings in Alaska and Canada, but disease in humans or horses has rarely been reported, only in Canada.
Susac syndrome: a case report with initial presentation of incomplete bitemporal hemianopia
Authors: Gunaratnam Cadric , King Thomas , Moloney Thomas P , Boggild Mike , Goodwin Todd 
Published: October 2023

Abstract
Susac syndrome (SS) is a rare microangiopathy affecting the precapillary arterioles of the brain, inner ear, and retina. We present a novel case of SS, presenting as acute incomplete bitemporal field loss in addition to temporally spaced neurological and vestibulocochlear symptoms. A 39-year-old female was referred to the ophthalmology clinic with acute incomplete bitemporal hemianopia and worsening hemicrania. History revealed progressive hearing loss, subjective short-term memory impairment, and vertigo temporally spaced over the preceding 12 months. Magnetic resonance brain revealed multiple small colosal lesions and liner ‘spoke’ lesions. Fundus fluorescein angiography revealed multiple branch retinal artery occlusions in the right eye. Audiometry confirmed bilateral sensorineural hearing loss. Treatment included intravenous corticosteroids and rituximab. This case highlights the importance of early consideration and evaluation of SS in individuals presenting with atypical ocular disturbances, where no clear cause can be elicited, in order to limit the sequelae of disease.
A CRISPR/Cas9-based kinome screen identifies ErbB signaling as a new regulator of human naïve pluripotency and totipotency
Authors: Li Jiayu , Lin Xiwen , Xie Liangfu , Zhao Jingru , Han Chunsheng , Deng Hongkui , Xu Jun 
Published: October 2023

Abstract
Regulation of totipotency and naïve pluripotency is crucial for early human embryo development. However, the mechanisms of naïve pluripotency and totipotency regulation in humans, especially the signaling pathways involved in these processes, remain largely unknown. Here, using the conversion of human extended pluripotent stem cells (hEPSCs) to naïve pluripotent stem cells as a model, we performed a CRISPR/Cas9-based kinome knockout screen to analyze the effect of disrupting 763 kinases in regulating human naïve pluripotency. Further validation using small molecules revealed that the inhibition of ErbB family kinases promoted the transition of hEPSCs to human naïve pluripotent stem cells. More importantly, chemical inhibition of the ErbB family also promoted induction of totipotent signatures in human pluripotent cells under different culture conditions. Our findings provide new mechanistic insights into the regulation of naïve pluripotency and totipotency in humans.
Hydrodynamic simulations of the KT Eridani nova super-remnant
Authors: Healy-Kalesh M W , Darnley M J , Shara M M , Lanzetta K M , Garland J T , Gromoll S 
Published: October 2023

ABSTRACT
A nova super-remnant (NSR) is an immense structure associated with a nova that forms when frequent and recurrent nova (RN) eruptions sweep up surrounding interstellar medium (ISM) into a high-density and distant shell. The prototypical NSR, measuring over 100 pc across, was discovered in 2014 around the annually erupting nova M 31N 2008-12a. Hydrodynamical simulations demonstrated that the creation of a dynamic NSR by repeated eruptions transporting large quantities of ISM is not only feasible but that these structures should exist around all novae, whether the white dwarf (WD) is increasing or decreasing in mass. But it is only the RN with the highest WD masses and accretion rates that should host observable NSRs. KT Eridani is, potentially, the eleventh RNe recorded in the Galaxy and is also surrounded by a recently unveiled H α shell tens of parsecs across, consistent with an NSR. Through modelling the nova ejecta from KT Eri, we demonstrate that such an observable NSR could form in approximately 50 000 yr, which fits with the proper motion history of the nova. We compute the expected H α emission from the KT Eri NSR and predict that the structure might be accessible to wide-field X-ray facilities.
Suppression of small-scale dynamo in time-irreversible turbulence
Authors: Kopyev A V , Il’yn A S , Sirota V A , Zybin K P 
Published: October 2023

ABSTRACT
The conventional theory of small-scale magnetic field generation in a turbulent flow considers time-reversible random flows. However, real turbulent flows are known to be time irreversible: the presence of energy cascade is an intrinsic property of turbulence. We generalize the ‘standard’ model to account for the irreversibility. We show that even small time asymmetry leads to significant suppression of the dynamo effect at low magnetic Prandtl numbers, increases the generation threshold, and may even make generation impossible for any magnetic Reynolds number. We calculate the magnetic energy growth rate as a function of the parameters of the flow.
Ultra-processed food intake among South Asians in the United States: Specific vulnerabilities of a growing immigrant population group
Authors: Hussain Bridget Murphy , Juul Filippa , Deierlein Andrea L , Parekh Niyati 
Published: October 2023

Abstract
South Asians are among the fastest growing immigrant population groups in the United States. Their traditional diets are rich in minimally processed fruits, vegetables, grains, herbs, and spices. However, the proliferation of ultra-processed foods (highly processed, industrially manufactured formulations) around the globe may compromise the nutrition profile of South Asians, threatening to increase their risk of noncommunicable diseases. This commentary discusses the rise in ultra-processed food consumption among South Asians in the United States and hypothesizes that South Asians may be especially vulnerable to the effects of ultra-processed foods due to their unique cardiovascular disease risk profiles. Using these emerging data, we propose several strategies for preventing the overconsumption of ultra-processed foods among South Asian Americans. These include the implementation of policies to encourage the consumption of whole foods over ultra-processed foods and the development of culturally tailored interventions, which include promoting consumption of traditional diets, improving affordability of healthful, culturally appropriate foods, and cultivating healthier food environments for South Asians living in the United States.
Hepatitis C Treatment Uptake Following Dried Blood Spot Testing for Hepatitis C RNA in New South Wales, Australia: The NSW DBS Pilot Study
Authors: Conway Anna , Stevens Annabelle , Murray Carolyn , Prain Bianca , Power Cherie , McNulty Anna , Carrington Nigel , Lu Heng , Kingsland Melanie , McGrath Colette , Read Phillip , Starr Mitchell , Catlett Beth , Cunningham Philip , Grebely Jason 
Published: October 2023

Abstract

Background
Dried blood spot (DBS) testing for hepatitis C virus (HCV) RNA provides a sampling option that avoids venepuncture and can be carried out in a nonclinical setting. Large-scale evaluations are needed to understand how DBS testing can reduce HCV burden. This study estimated prevalence of, and factors associated with, HCV RNA and treatment initiation among people enrolled in a state-wide pilot of people testing in the NSW DBS Pilot in New South Wales, Australia.

Methods
People at risk of HIV/HCV could participate via (1) self-registration online with a DBS collection kit delivered and returned by conventional postal service; or (2) assisted DBS sample collection at a community site or prison. Logistic regression was used to identify factors associated with detectable HCV RNA and treatment initiation within 6 months of testing.

Results
Between September 2017 and December 2020, 5960 people were tested for HCV (76% men, 35% Aboriginal and/or Torres Strait Islander, 55% recently injected drugs): 21% online self-registration, 34% assisted registration in the community, 45% assisted registration in prison. Fifteen percent had detectable HCV RNA (878/5960). Overall, 44% (n = 386/878) of people with current HCV initiated treatment within 6 months (13% online self-registration, 27% assisted registration in the community, 61% assisted registration in prison). Testing in prison compared with the community (adjusted odds ratio [aOR], 4.28; 95% CI, 3.04–6.03) was associated with increased odds of treatment initiation. Being a woman compared with a man (aOR, 0.68; 95% CI, 0.47–0.97) was associated with reduced treatment initiation.

Conclusions
The NSW DBS Pilot demonstrates the feasibility of using DBS to promote HCV testing and treatment in community and prison settings.