bluuebunny/crossref_metadata_2025_split huggingface dataset:
Deucravacitinib, an Oral, Selective, Allosteric Tyrosine Kinase 2 Inhibitor, in Moderate to Severe Plaque Psoriasis: Evaluation of Creatine Phosphokinase Elevations in the Phase 3 POETYK PSO-1 and PSO-2 Trials
Authors: Lebwohl Mark , Strober Bruce , Scharnitz Thomas , Linaberry Misti , Hoyt Kim , Banerjee Subhashis , Kisa Renata M. , Martin George 
Published: November 2023

Introduction: Deucravacitinib, an oral, selective, allosteric tyrosine kinase 2 inhibitor, is approved in the US, EU, and other countries for the treatment of adults with moderate-to-severe plaque psoriasis who are candidates for systemic therapy. In the phase 3 POETYK PSO-1 (NCT03624127) and POETYK PSO-2 (NCT03611751) trials, deucravacitinib was significantly more efficacious than placebo or apremilast and was well tolerated. This pooled safety analysis of POETYK PSO-1 and PSO-2 assessed changes from baseline in creatine phosphokinase (CPK) levels and CPK elevations and rhabdomyolysis adverse events (AEs) in patients receiving placebo, deucravacitinib, or apremilast.
Methods: Patients with moderate to severe plaque psoriasis were randomized 1:2:1 to oral placebo, deucravacitinib 6 mg once daily, or apremilast 30 mg twice daily. Shifts from baseline in severity grade (Common Terminology Criteria for Adverse Events [CTCAE] version 5) of CPK levels were analyzed. Elevated CPK and rhabdomyolysis adverse events (AEs) were reported.
Results: The pooled population included 1683 patients (placebo, n=419; deucravacitinib, n=842; apremilast, n=422). At baseline, the proportions of patients with grade ≥1 CPK levels were comparable (placebo, 6.3%; deucravacitinib, 5.9%; apremilast, 7.4%). During Weeks 0-16, worsening of CPK levels by >1 CTCAE grade from baseline occurred at similar rates in patients receiving placebo (2.2%), deucravacitinib (2.5%), and apremilast (1.4%). Most deucravacitinib-treated patients maintained their baseline CPK CTCAE grade or shifted to a lower grade through Week 52. Elevated CPK AEs were reported in 1.2% (placebo), 2.7% (deucravacitinib), and 0.7% (apremilast) of patients through Week 16. Exposure-adjusted incidence rates (EAIRs) of elevated CPK AEs through Week 52 were comparable across treatments (placebo, 4.5/100 person-years [PY]; deucravacitinib, 4.7/100 PY; apremilast, 3.6/100 PY). Two deucravacitinib-treated patients (0.2/100 PY) and 1 apremilast-treated patient (0.4/100 PY) discontinued due to AEs of asymptomatic elevated CPK. Two deucravacitinib-treated patients had rhabdomyolysis with potential inciting events, one of which was associated with CPK elevation.
Conclusion: Most deucravacitinib-treated patients maintained their baseline CPK grade or shifted to a lower grade through Weeks 16 and 52. The EAIR of CPK elevation AEs were comparable across treatment groups over 52 weeks.
A Systematic Literature Review and Network Meta-Analysis of Comparative Efficacy of Topical Fixed-Dose Combination Treatments for Moderate to Severe Acne Vulgaris
Authors: Harper Julie C , Baldwin Hilary E , Choudhury Saswata Paul , Ghosh Bikramaditya , Rai Deepti , Aman Md Sohail , Roy Choudhury Abhra , Dey Debalina , Dutta Sekhar K , Bhattacharyya Subrata , Lin Tina , Joseph George , Dashputre Ankur A , Tan Jerry 
Published: November 2023

INTRODUCTION: Several topical and oral monotherapies/combination treatments are available for treating patients with moderate to severe acne vulgaris and a few are currently under review with the United States (US) Food and Drug Administration (FDA). Among these treatments, topical fixed-dose combinations (FDCs) are widely used in the US. No study has assessed the comparative efficacy of topical FDCs based on the treatment success endpoint of the proportion of patients achieving ≥2 grade reduction AND "Clear" or "Almost clear” status by week 12 on an Investigator's Global Assessment (IGA) or equivalent scales. The objective of this study was to conduct a systematic literature review (SLR) and network meta-analysis (NMA) to compare the efficacy of topical FDCs for the treatment of moderate to severe acne.
STUDY DESCRIPTION: An SLR was conducted for identifying randomized controlled trials (RCTs), that included at least one topical FDC (currently approved/under review with FDA) arm, in academic (MEDLINE, Embase, Cochrane CENTRAL, PEDE, and NHS EED) and non-academic databases (HTA databases, conference abstracts databases, and trial registries). The search was conducted in May 2022, based on a pre-specified inclusion/exclusion criterion. RCTs included in the analysis evaluated acne severity using IGA or equivalent (Evaluator's Global Severity Score, Investigator’s Static Global Assessment) scales. A Bayesian network meta-regression was conducted, using the proportion of patients with moderate acne, inflammatory and non-inflammatory lesion counts at baseline as covariates to account for acne severity.
RESULTS: Twelve Phase II/III/IV RCTs were identified from 5,159 citations comprising 8,349 patients across 8 treatment groups. The odds ratio for treatment success with topical FDC of clindamycin phosphate 1.2%, adapalene 0.15%, and benzoyl peroxide 3.1% (first triple agent FDC) gel was estimated to be 7.61 (95% Credible Interval: 4.44 –13.20) in comparison to Vehicle gel. Comparative effectiveness ranking demonstrated that the topical triple agent FDC gel was the most effective treatment with surface under cumulative ranking of 100%.
CONCLUSION: Based on this SLR/NMA, the topical triple agent FDC of clindamycin phosphate 1.2%, adapalene 0.15%, and benzoyl peroxide 3.1% gel, which is currently under FDA review (PDUFA date 10/20/2023), was clinically superior to all other topical FDC treatments for moderate to severe acne vulgaris.
PENGARUH JENIS KEMASAN TERHADAP KARAKTERISTIK FISIKOKIMIA DAN SENSORI KOPI ARABIKA GAYO DENGAN METODE PENGOLAHAN SEMI BASAH
Authors: Silaban Rutdiani , Sinaga Hotnida , Karo-Karo Terip 
Published: November 2023

<p class="10Judulbab">Indonesia is the 4th largest coffee producer after Brazil, Vietnam and Colombia. The largest Arabica coffee production center in Indonesia is in Central Aceh District. Biophysical factors, such as soil conditions, climate and altitude, which are planted at an altitude of 1,000-1,400 meters above sea level are the factors that make Gayo Arabica coffee green bean known as a special coffee that has a strong coffee taste and characteristics. Coffee has a lot of chemical content in it, for example the content of chlorogenic acid and caffeine. Physicochemical analysis of the samples included moisture content, ash content, fat content, protein content, caffeine content, phenol content, acidity level (pH), and specific volume. This data analysis used a completely randomized design with 3 replications comparing coffee from each coffee processing using five types of storage packaging for 4 months. Semi-wet processed coffee has the characteristics of moderate acidity, sweet taste, medium to low.</p><p class="10Judulbab"> </p><p class="10Judulbab">Keywords:<em> Gayo Arabica, semi washed, green bean, storage, Packaging</em></p>
Perubahan Mutu Buah Pepaya Varietas IPB 9 (Calina) Selama Penyimpanan Pasca Simulasi Transportasi
Authors: Ismaya Pandu Legawa , Faturochman Hadi Yusuf , Darmawati Emmy , Setyadjit Setyadjit 
Published: November 2023

<p class="AbstakIndo"><em>Papaya (Carica Papaya L.) IPB 9 (calina) variety is a papaya fruit that has thick, sweet flesh and very high fruit productivity. During the transportation process of papaya, mechanical damage (bruises, abrasions, weight loss) and physiological damage often occur, which can cause papaya decrease in quality during storage before consumption. The purpose of this study was to determine changes in the quality of papaya after 2-hour transportation simulation. The research design used a randomized block design (RAK) with the treatment of the position of the fruit in the packaging, which was stored horizontally (KS1) and vertically (KS2) during the transportation simulation process. Papaya hat has been simulated for transportation is stored at 18–2</em><em>0</em><em><sup>o</sup></em><em>C for 12 days. </em><em>Q</em><em>uality of papaya weight loss stored for 12 days for KS1 reached 7.34% and KS2 reached 7.43%. </em><em>H</em><em>ardness quality of papaya stored for 12 days for KS1 is 0.84 kgf, and for KS2, it is 0.76 kgf. </em><em>Q</em><em>uality of papaya skin color after 12 days of storage decreased the freshness of the papaya fruit, but it was still fit for consumption. </em><em>T</em><em>otal dissolved solids content after being stored for 12 days for KS1 reached 11.45% and KS2 reached 11.32%.</em><em></em></p>
Sosialisasi Bahaya Leptospirosis dan Pelatihan Cuci Tangan Pada Santri Pondok Pesantren Ibrohimiyyah Demak
Authors: Fristiani Arista Kurniasari Budi , Pristiyani Oni Oktavia , Windyaningrum Ana Maria Ika Devy , Darmaji Khamdan , Lestari Ina , Dian Roykhana Maya Kholida , Wardhana Andhy Kusuma , Nugroho Dwi Agusatya , Sholikhati Vivi , Iftihatunnisa Augia Nur , Putri Valentine Selviona 
Published: November 2023

Latar belakang: Leptospirosis merupakan zoonosis yang diperatarai oleh bakteri. dapat masuk ke dalam tubuh manusia melalui kulit yang luka atau membran mukosa (hidung, mulut, dan mata). menerapkan Perilaku Hidup Bersih dan Sehat (PHBS), sehingga dapat memutus rantai penularan dan mengurangi risiko terpapar bakteri Leptospira Tujuan: memberikan penyuluhan tentang Leptospirosis kepada santriwan dan santriwati Pondok Pesantren Ibrohimiyyah Mranggen-Demak agar konsisten dalam menerapkan PHBS Metode: Kegiatan pengabdian masyarakat ini dilakukan dengan penyuluhan langsung menggunakan media power point, poster dan pelatihan serta pendampingan tentang cara cuci tangan yang sesuai standar kesehatan. Hasil: hasil nilai kuesioner pretest dan posttest pada peserta penyuluhan bahaya leptospirosis dan pelatihan cara mencuci tangan menunjukkan terdapat peningkatan nilai dari sebelum dan sesudah kegiatan penyuluhan, rata-rata nilai pretest adalah 3,8 dengan nilai tertinggi 6 dan rata-rata nilai posttest adalah 9,4 dengan nilai tertinggi 10 yang diperoleh 43 peserta. Kesimpulan: terjadi peningkatan pengetahuan santriwan dan santriwati tentang leptospirosis dan cuci tangan yang baik dan benar.
Kata kunci: cuci tangan, leptosprirosis, PHBS
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Abstract
Background: Leptospirosis is a zoonosis mediated by bacteria. can enter the human body through broken skin or mucous membranes (nose, mouth and eyes). implement Clean and Healthy Behavior (PHBS), so as to break the chain of transmission and reduce the risk of exposure to Leptospira bacteria. Objective: provide counseling about Leptospirosis to students and female students of the Ibrohimiyyah Mranggen-Demak Islamic Boarding School so that they are consistent in implementing PHBS. Method: This community service activity is carried out by direct counseling using power point media, posters and training as well as mentoring on how to wash hands according to health standards. Result: the results of the pretest and posttest questionnaire values ​​for participants in the education on the dangers of leptospirosis and hand washing training showed that there was an increase in scores before and after the counseling activities, the average pretest score was 3.8 with the highest score being 6 and the average posttest score being 9 .4 with the highest score of 10 obtained by 43 participants. Conclusion: there is an increase in the knowledge of female and female students about leptospirosis and proper and proper hand washing.
Keywords: hand washing, leptospirosis, PHBS
Kampanye Aksi Bergizi pada Remaja di Kabupaten Sleman
Authors: Siswati Tri , Olfah Yustiana , Setiyobroto Idi , Ramayulis Rita , Waris Lukman , Prayogi Agus Sarwo 
Published: November 2023

Latar belakang: Remaja merupakan salah satu kelompok rentan gizi. Untuk meningkatkan derajat kesehatan remaja, perlu dilakukan upaya edukasi, salah satunya melalui kampanye aksi bergizi. Tujuan: Kegiatan ini bertujuan untuk meningkatkan pengetahuan remaja tentang anemia dan gizi seimbang serta meningkatkan cakupan konsumsi tablet Fe. Metode: Kegiatan pengabdian masyarakat ini dilakukan di SMPN Gamping, Sleman pada bulan Juli 2023. Jumlah partisipan adalah semua siswa baru sebanyak 192 orang. Aksi bergizi dilakukan melalui kampanye dengan memberikan edukasi tentang gizi seimbang dan anemia, minum tablet Fe, penandatanganan deklarasi aksi bergizi dan komitmen untuk hidup sehat. Hasil: Sebagian besar partisipan adalah perempuan (53,1%), umur 13 tahun (57,3%). Berkaitan dengan kebiasaan hidup sehat, sebagian besar kadang-kadang sarapan (40,6%) dan pergi ke sekolah dengan moda transportasi pasif berupa kendaraan bermotor (motor/mobil). Setelah mengikuti edukasi pengetahuan remaja tentang gizi seimbang dan anemia mengalami peningkatan masing masing 21% dan 19% dengan kategori nilai baik (>76). Kesimpulan: Kampanye aksi bergizi efektif untuk meningkatkan pengetahuan remaja tentang anemia dan gizi seimbang, sehingga kampanye aksi bergizi merupakan salah satu alternatif upaya meningkatkan derajat kesehatan remaja.
Kata kunci: aksi bergizi, anemia, hidup sehat, kampanye, remaja
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Abstract
Background: Nutritionally, adolescents are one of the most vulnerable populations. To enhance adolescent health, it is necessary to engage in educational efforts, one of which is the implementation of nutritious action campaigns. Objective: This activity aims to increase adolescent knowledge about anemia and balanced nutrition and increase the coverage of Fe tablet consumption. Method: his community service activity will be carried out at SMPN Gamping, Sleman, in July 2023. The number of participants was all new students—as many as 192 people. Nutritious action is carried out through campaigns by providing education on balanced nutrition and anemia, taking Fe tablets, and signing a declaration of nutritious action and commitment to healthy living. Result: Most of the participants were women (53.1%) and 13 years old (57.3%). With regard to healthy living habits, most people sometimes eat breakfast (40.6%) and go to school with passive transportation modes in the form of motor vehicles (motorbikes or cars). After participating in education, adolescents' knowledge about balanced nutrition and anemia increased by 21% and 19%, respectively, with good value categories (>76). Conclusion: Nutritious action campaigns are effective in increasing adolescent knowledge about anemia and balanced nutrition, so nutritious action campaigns are one alternative effort to improve adolescent health.
Keywords: aksi bergizi, anemia, healty life tyle, campaign, adolescent
Cuando las monta&ntilde;as son paisaje, y otros poemas
Authors: Ronderos Clara Eugenia 
Published: November 2023

Clara Eugenia Ronderos es poeta y cuentista colombiana doctorada en Literatura Hispánica de la Universidad de Massachusetts Amherst. Sus libros más recientes son el poemario Vida profunda y la colección de relatos Doble filo (Córdoba, Argentina: Alción, 2023). Otras publicaciones incluyen las colecciones de relatos Agua que no has de beber (Alción, 2019) y Ábrete Sésamo (Madrid: Torremozas, 2016); y los poemarios Unfoldings (Massachusetts: Nixes Mate, 2021), Después de la fábula (Madrid: Verbum, 2018), De reyes y fuegos (Torremozas, 2018), The Poetry of Clara Eugenia Ronderos (Seasons of Exile, Lewiston NY: Mellen. Traducción Mary G Berg, 2015), Raíz del Silencio (Bogotá: Universidad de los Andes, 2012) y Estaciones en Exilio (Premio Carmen Conde, Torremozas, 2010). Ronderos vive entre los Estados Unidos y Colombia y se dedica a la escritura, luego de jubilarse como profesora titular de español y literatura en la Universidad de Lesley de Cambridge, Massachusetts.
Deskripsi Kebutuhan Guru Terhadap Pembuatan Bahan Ajar Berbasis Phenomenon-Based Learning Materi Fluida
Authors: Anggreani Yulita , Sundari Putri Dwi , Mufit Fatni , Dewi Wahyuni Satria 
Published: November 2023

Teaching materials are a crucial aspect in the process of learning. In the process of learning, it is necessary to have teaching materials that can increase students' understanding of concepts. One of the solutions that can be made is to bring students closer to everyday phenomena. This research was conducted as a basis for developing teaching materials based on phenomenon-based learning. The research type used is descriptive qualitative. The samples used were three physics teachers. The instruments for research used were interview sheets and literature review. The interview topics related to learning conditions at school, learning resources, learning models and obstacles faced in the process of learning. Based on the conditions in the field, teachers still really need learning resources that can increase the enthusiasm of students to learn, by bringing students closer to phenomena in the surrounding environment, so students can understand learning material quickly and correctly. The results shown that teachers need materials for teaching based on phenomenon-based learning to support student understanding, particulary in fluid material. Therefore, the research results can be used as a basis for research to develop teaching materials based on phenomenon-based learning
Pelatihan Guru SMA: Identifikasi Potensi Rempah dan Jamu secara In Silico
Authors: Supiyanto Supriyanto , Nurhidayah Enung Siti , Hidayati Darimiyya , Rahman Askur , Probowati Banun Diyah , Firmansyah R. Arief , Maflahah Iffan , Rakhmawati Rakhmawati , Fahkry Muhammad 
Published: November 2023

Peningkatan pengetahuan agroindustri jamu dan rempah sangatlah penting bagi masyarakat madura. Pengabdian masyarakat yang dilaksanakan oleh prodi TIP adalah pelatiahan penggunaan softwere berbasis web untuk identifikasi rempah dan jamu secara in silico kepada guru kimia dan biologi SMA di Kabupaten Pamekasan. Tujuannya untuk meningkatkan literasi digitalguru kimia dan biologi yang dapat mempermudah melakukan identifikasi potensi rempah dan jamu. Abdimas ini menggunakan metode pelatihan dan evaluasi kegiatan menggunakan kuesioner. Kegiatan abdimas ini sangat bermanfaat bagi guru kimia dan biologi karena dapat meningkatkan literasi digital dan dapat mempermudah melakukan identifikasi potensi rempah dan jamu dan secara umum para peserta pelatihan merasa puas dengan pelatihan ini baik dari topik, kompetensi narasumber, penyampaian materi, durasi materi maupun alat peraga pelatihan.

The increasing knowledge of the herbs and spices agroindustry is very important for the people of Madura. In response, the TIP study program conducted a community service through training on web-based software in silico to identify the spices and herbs for high school chemistry and biology teachers in Pamekasan Regency. Its goal is to increase the digital literacy of chemistry and biology teachers to simplify the identification of potential spices and herbs. The training and evaluation based on questionnaires are used as the method. This ABDIMAS is very useful for chemistry and biology teachers since it improves digital literacy and makes identifying the potential of spices and herbs easier. In general, the trainees are satisfied with the topic, the resource person's competence, the material's delivery, the material's duration, and the training aids provided in this event.
Peningkatan Pengetahuan Masyarakat Tentang Pola Hidup Sehat Pada Masa Pandemi Covid-19 di Perum Ganesha Pedurungan Semarang
Authors: Afriansya Roni , Setyowatiningsih Lilik , Sofyanita Eko Naning 
Published: November 2023

Pandemi Covid-19 merupakan masalah kesehatan global di dunia. Pada masa pademi Covid-19 banyak masyarakat mencari informasi tentang cara mempertahankan kesehatan dan kekebalan tubuh serta cara agar tidak tertular virus Covid-19. Sejak awal maret 2020 hingga 1 maret 2023 ada 6,7 juta kasus terkonfirmasi masyarakat yang terinfeksi Covid-19 di Indonesia. Pemerintah membentuk gugus tugas untuk menekan penyebaran Covid-19. Selain itu, sebagai individu kita juga berkewajiban untuk mencegah penyebaran virus ini. Untuk itu, peningkatan pengetahuan masyarakat terutama pola hidup sehat sangat diperlukan. Tujuan dari pengabdian masyarakat ini memberikan edukasi kepada masyarakat tentang pola hidup sehat dengan cara memberikan informasi dan edukasi cara cuci tangan yang benar. Metode edukasi dilakukan dengan memberikan penyuluhan atau penjelasan kepada masyarakat di lingkungan kampus. Hasil penyuluhan kepada masyarakat dengan jumlah 100 orang yang terdiri laki-laki (44%) dan perempuan (56%). Rata-rata hasil skor pengetahuan sebelum penyuluhan 68 dan sesudah penyuluhan 95. Selisih antara skor pengetahuan sesudah dan sebelum dari masyarakat yang mendapatkan penyuluhan pola hidup sehat adalah 28. Hasil ini menunjukkan bahwa ada peningkatan pengetahuan masyakat setelah dilakukan edukasi tentang Pola Hidup Sehat.

The Covid-19 pandemic is a global health problem in the world. During the Covid-19 pandemic, many people were looking for information on how to maintain health and immunity as well as ways to prevent contracting the Covid-19 virus. Since the beginning of March 2020 until March 1 2023 there have been 6.7 million confirmed cases of people infected with Covid-19 in Indonesia. The government formed a task force to suppress the spread of Covid-19. Apart from that, as individuals we are also obliged to do something to prevent the spread of this virus. For this reason, increasing public knowledge, especially a healthy lifestyle, is very necessary. The purpose of this service is to provide education to the public about Healthy Lifestyles by providing information and education on how to wash hands properly. The educational method is carried out by providing counseling or explanations to the community on campus. The results of outreach to the community with a total of 100 people consisting of 44% male and 56% female, the average score of knowledge before counseling is 68 and after counseling is 95. healthy living is 28. These results explain if there is an increase in community knowledge after education about healthy lifestyles.