bluuebunny/crossref_metadata_2025_split huggingface dataset:
Phytochemical profiles and antimicrobial activity of the inflorescences of Sorbus domestica, S. aucuparia, and S. torminalis
Authors: Lykholat Y. V. , Khromykh N. O. , Liashenko O. V. , Sklyar T. V. , Anishchenko A. O. , Balalaiev O. K. , Holubieva T. A. , Lykholat T. Y. 
Published: November 2023

The genus Sorbus L. is known for its extremely complex taxonomical relationships and health-promoting phytochemicals included in the composition of its floral constituents. The inflorescences of three Sorbus species (rowans), characterized by distinct molecular-genetic traits, were studied in order to examine the possible chemotaxonomic and antimicrobial value of their metabolites. GC–MS profiling of the hexane extracts of S. domestica, S. aucuparia, and S. torminalis inflorescences identified a total of 87 components, which represented six chemical classes (hydrocarbons, alcohols, esters, fatty acid, aldehydes, and ketones) and miscellaneous minor floral constituents (1-methylinosine, 5-amino tetrazole, 1,4-dimethylbenzene, 3,5-bis(1,1-dimethylethyl)-phenol, 3-acetoxy-7,8-epoxylanostan-11-ol, cycloeucalenol acetate, etc.). Principal component analysis (PCA) of the qualitative and quantitative heterogeneity of the floral metabolites determined 1-hentetracontanol, nonacosane, pentadecyl acrylate, 1-methylhexacosane, cycloeucalenol acetate, butyl acetate, and urs-12-ene as the main components which contributed to the differences between S. domestica, S. aucuparia and S. torminalis and resulted in the distinction between the rowan species. Disc-diffusion assays showed variability in activity of inflorescence extracts against Gram-negative (Enterobacter dissolvens, Escherichia coli, Pseudomonas aeruginosa, and Klebsiella pneumoniae) and Gram-positive (Micrococcus lysodeikticus, Staphylococcus aureus, and S. epidermidis) bacterial and clinical fungal (Candida albicans) strains. The effect of S. torminalis was high against S. epidermidis and P. aeruginosa, while it was at its lowest against clinical C. albicans strains. Inflorescences of S. domestica showed the highest inhibition of P. aeruginosa, and moderate effects against S. epidermidis and C. albicans. Inflorescences of S. aucuparia caused low to moderate growth inhibition of both Gram-positive and Gram-negative bacterial strains, while it showed the highest effect on C. albicans. Antimicrobial properties of rowan inflorescences may be attributed to oleic, linoleic, arachidic, hexadecanoic, and pentadecanoic acids, 24-norursa-3,12-diene, hexahydrofarnesyl acetone, cycloeucalenol acetate, and other compounds which have known bioactivity. These findings indicated rowan inflorescences as a rich source of valuable secondary metabolites and allow us to assume an application of the floral constituents as chemotaxonomic markers of the genus Sorbus species.
Direction Estimates for Short-Period P-Waves on Three-Component Stations and Arrays
Authors: Gibbons Steven J. 
Published: November 2023

Abstract
P-arrival backazimuth estimates can be crucial in locating poorly constrained seismic events. Correlating short windows of the vertical waveform with corresponding windows of the radial rotation for different backazimuths can provide estimates, but these are often uncertain and biased due to skewness in the Z–R correlation functions. Assessing how well cosine curves centered on different backazimuths match the Z–R correlation functions provides more reliable estimates that depend less upon the time-window used. Stacking best-fit-cosine curves from neighboring three-component stations improves stability further in a form of array-processing that does not require coherence between the waveforms themselves. We demonstrate for recordings of North Korean nuclear tests at the Pilbara 3C array in Australia that the biases in the Z–R correlation functions vary greatly between adjacent stations. This bias is reduced both by the cosine curve fitting and stacking operations. We advocate obtaining backazimuth estimates for all P arrivals at three-component stations globally. This could improve phase association and event location, identify sensor orientation problems, and provide baseline backazimuth corrections and uncertainty estimates. We propose two benchmark datasets for developing, documenting, and comparing backazimuth estimation algorithms and codes. All the data and code used to generate the results presented here are open.
The use of race quiz media to increase students interest in learning mathematics on the material of whole numbers class VII D SMP Negeri 3 Lawang academic year 2023-2024
Authors: Primandanu Teguh 
Published: November 2023

With the advancement of science and technology, it is expected to facilitate students in learning mathematics. One method that can be used to learn mathematics is through technology-based media that can be accessed easily by teachers and students. This research is a collaborative classroom action research that aims to increase the interest in learning mathematics of students in class VII D SMP Negeri 3 Lawang in the 2023-2024 school year by using the "Race Quiz" media. The subjects in this study were students of class VII D SMP Negeri 3 Lawang in the academic year 2023-2024 as many as 32 students consisting of 16 male students and 16 female students. The cycle in this Classroom Action Research uses the Kemmis Me Taggart model with the stages of planning, implementation, observation, and observation The instruments used to collect data were observation sheets of learning activities, student response questionnaires for each cycle, and interviews with mathematics teachers. The data obtained was analysed using quantitative descriptive analysis to determine the increase in students' interest in learning mathematics using the "Race Quiz media. Based on pre-cycle data, it shows that students' interest in learning mathematics is 68% so that it can be categorised as sufficient. This class action research was conducted in 2 cycles. The observation results showed an increase in students interest in learning mathematics in the learning process by 6% from 76% in cycle I to 82% in cycle II, so it can be categorised as very high. Therefore, the existence of technology-based learning media is expected to increase students' interest in learning mathematics
Possibilities of transition of the strategy from glucosecentricity to organoprotection when prescribing antidiabetic drugs in patients with type 2 diabetes mellitus in the perimenapause
Authors: Smirnov V. V. , Semenova Yu. B. , Shapovalova A. B. , Matveeva N. N. , Zubarev V. A. 
Published: November 2023

Obesity, type 2 diabetes mellitus and cardiovascular diseases associated with these conditions remain one of the largest global health problems. According to statistics, at least 90 % of patients with type 2 diabetes mellitus are obese or at least overweight (BMI > 25). Very often, the cause of death in this cohort of patients is the development of a cardiovascular catastrophe. Currently, there is a gradual rejection of the exclusively glucose-centric concept of type 2 diabetes mellitus therapy in favor of an organoprotective one. In this article, we examined the possibility of using various groups of incretinomimetics (DPP-4 inhibitors and GLP-1 agonists) in the primary prevention of cardiovascular diseases in patients with type 2 diabetes mellitus in perimenopause, and comparing their effects with traditional metformin therapy.The aim of the study was to evaluate the effect of non – insulin antidiabetic drugs from the class of incretinomimetics on risk factors for the development of cardiovascular diseases in patients with type 2 diabetes mellitus in perimenopause.Object and methods. A dynamic examination of three groups of patients was carried out. The first group (n = 22) received therapy with the GLP-1 agonist semaglutide, the second group (n = 30) metformin therapy and the third (n = 19) with the DPP-4 inhibitor linagliptin. All patients, in addition to general clinical examination, assessment of the dynamics of weight loss and insulin resistance, underwent a dynamic study of triglyceride levels, low – density lipoprotein cholesterol, as well as markers of general inflammation – C-reactive protein and interleukin-6.Results. The results of the study showed that semaglutide and metformin were equally effective in reducing body weight, but metformin and linagliptin did not significantly affect the level of atherogenic fractions of the lipidogram, unlike semaglutide. Nevertheless, both semaglutide, linagliptin, and metformin reduced the level of markers of general inflammation.Conclusions. The results of the study allow us to discern a certain cardioprotective potential not only in agonists of GLP-1, but also in representatives of the class of DPP-4 inhibitors, which requires further research.
Features of bioelectric brain activity in people with different level of situational anxiety when performing non-verbal tasks
Authors: Pavlenko S. I. , Gromova D. S. , Vedyasova O. A. , Kovalev A. M. , Budaev A. I. 
Published: November 2023

The purpose of the study: to analyze the parameters of the electroencephalogram in individuals with different levels of anxiety when performing non-verbal tasks.Object and methods. The study was conducted on 20 female students, aged 18 to 22 years. All studies were carried out on a voluntary basis, confirmed in writing, in compliance with bioethical standards governing the conduct of observations on humans. The level of situational anxiety was determined using the Spielberg-Khanin test.The spectral power of the electroencephalogram rhythms was recorded using the NVX 36 digital DC EEG neurovisor using a cap with a set of electrodes that were placed on the head of the subjects according to the international 10–20 system. The EEG recording lasted 1–2 minutes before and during the performance of nonverbal tasks. As non-verbal tasks, the subjects were asked to complete the Portsus maze test and the Cattell intellectual test. The results obtained were statistically processed. Differences were considered statistically significant at p < 0.05. All data obtained are presented as arithmetic means ± standard errors of the mean, as well as changes in average values in %.Research results. It was found that the dynamics of EEG parameters in the performance of nonverbal tasks in students depends on the level of their situational anxiety. In persons with a low level of situational anxiety, when performing nonverbal tasks, an increase in the spectral power of the EEG parameters of beta2 and gamma waves in the frontal, parietal, occipital, and central leads is observed.In subjects with an average level of anxiety in the conditions of performing non-verbal tasks, the EEG parameters of beta2 and gamma waves in the frontal, occipital, and parietal leads noticeably increased. Persons with a high level of anxiety are characterized by an increase in the spectral power of alpha, beta2 and gamma rhythms in the frontal, central, parietal and occipital leads.
Molecular Landscape of Borderline Ovarian Tumors: A Systematic Review
Authors: Sadłecki Paweł , Walentowicz-Sadłecka Małgorzata 
Published: November 2023

Borderline ovarian tumors (BOTs) show intriguing characteristics distinguishing them from other ovarian tumors. This unique type of non-invasive neoplasms is characterized by atypical growth of epithelial cells, nuclear atypia, and a moderate-level mitotic activity that places BOTs between benign tumors and invasive cancers. Similar to invasive carcinomas, BOTs can be categorized into six histological subtypes based on the type of epithelial cells present. The most prevalent subtypes are serous and mucinous BOTs, whereas endometrioid, clear cell, seromucinous, and borderline Brenner tumors are diagnosed less often. Noticeably, molecular changes found in BOTs can vary on a case-by-case basis, which warrants further research on the molecular landscape of these tumors. Identifying carcinogenic mutations through molecular analysis and developing targeted therapies represent significant advancements in the diagnosis and treatment of ovarian malignancies.
A growing body of evidence indicates that BOTs often remain clinically dormant for extended periods before a molecular trigger initiates increased cell replication, potentially leading to carcinoma development or recurrence. Continued research in this area is crucial for improving risk assessment and developing personalized treatment approaches. While molecular studies have contributed significantly to our understanding of BOT pathogenesis, substantial research is still required to elucidate the relationship between ovarian neoplasms and extraneous disease, identify accurate prognostic indicators, and develop targeted therapeutic approaches. The aim of the present systematic review was to analyze the spectrum of molecular changes found in BOTs and discuss their significance in the context of the overall therapeutic approach.
Psychological, Social, and Behavioral Conditions of Anti-VEGF Patients: Results from the ALBATROS Data Collection
Authors: Wolfram Christian , Pfeiffer Norbert , Hudde Tobias , Klatt Alexander , Schnegelsberg Birthe , Ross Mike , Ziemssen Focke , Schuster Alexander K 
Published: November 2023

Background: Retinal diseases such as neovascular age related macular degeneration (nAMD), diabetic macular edema (DME) or branch-/central retinal vein occlusion (B/CRVO) have significant implications for patients&#039; social and psychological well-being. To gain a comprehensive understanding of patients&#039; backgrounds and attitudes, we developed an exploratory questionnaire, the Basic Care and Patient Satisfaction Questionnaire (BPZ-9).
Methods: The ALBATROS study aimed to assess the care situation of treatment-naïve patients diagnosed with either nAMD, DME or B/CRVO. The data collection took place at the beginning of treatment and after twelve months of anti-VEGF (vascular endothelial growth factor) therapy. The BPZ-9 instrument comprises nine questions to evaluate patients’ psychological and social situation and their satisfaction with treatment.
Results: Data were collected from 1.478 nAMD (mean 78 years), 445 DME (67 years), 233 BRVO (70 years) and 144 CRVO (71 years) patients at 102 study centers throughout Germany. Approximately one third of the patients was living alone and six percent were in organized care. One in four patients had difficulties to walk and one in five needed accompany for treatment. Anxiety to lose vision was present in three out of four patients at the beginning and slightly decreased to two out of three over the 12-month treatment preriod. The distress of having a retinal disease was generally higher than the distress related to treatment. Most patients reported high treatment satisfaction (73%) and felt well informed (81%).
Conclusion: Patients receiving anti-VEGF therapy commonly experience impaired mobility, dependency on others, distress and the fear of vision loss.
Dose-Dense Docetaxel-Cyclophosphamide and Epirubicin-Cisplatin(ddDCEP): Analysis of an alternative platinum-containing regimen in 116 patients with early triple negative breast cancer
Authors: Singh Ashish , Georgy Josh Thomas , Joel Anjana , Thumaty Divya Bala , John Ajoy Oommen , Ramnath Nithya , George Tarun K , Sharma Parth , Patole Shalom , Rebekah Grace , Sigamani Elanthenral , Manipadam Marie Therese , Cherian Anish Jacob , Abraham Deepak Thomas , Paul Mazhuvanchary Jacob , Balakrishnan Rajesh , Sebastian Patricia , Backianathan Selvamani , Chacko Raju Titus 
Published: November 2023

Abstract
We assessed the efficacy, tolerability, and cost-effectiveness of a novel neoadjuvant regimen comprising docetaxel-cyclophosphamide alternating with epirubicin-cisplatin (ddDCEP) administered biweekly for 16 weeks in 116 patients with early triple-negative breast cancer. This regimen achieved a high pathological complete response (ypT0/TisN0) rate of 55.2% and favorable survival outcomes (30-month event-free survival, 91.2%; overall survival, 97%). Febrile neutropenia was observed in 4.3% of patients, and 98% completed at least six of eight cycles. ddDCEP was more cost-effective than contemporary carboplatin-based regimens. This novel approach offers an economically viable and effective alternative to current chemoimmunotherapy regimens, and merits further investigation
Trends of antihypertensive, antidiabetic, and non-steroidal anti-inflammatory drugs use among the Health Workers Cohort Study, Mexico 2004 to 2018.
Authors: Ortega-Montiel Janinne , Montoya Alejandra , Soria-Saucedo René , Gallegos-Carrillo Katia , Ramírez-Palacios Paula , Salmerón Jorge , Salazar-Martinez Eduardo 
Published: November 2023

Abstract
Background
Hypertension and type 2 diabetes (T2D) are the most prevalent non-communicable diseases in Mexico and worldwide. According to international practice management guidelines, the principal chronic management therapy is daily oral medication.
Aim
We aim to describe the trends of antihypertensive, antidiabetic, and non-steroidal anti-inflammatory (NSAID) drugs use among the Mexican adult population from 2004-2018.
Methods
We analyzed data from the Health Workers Cohort Study (HWCS) for males and females aged > 18 years. We calculated the prevalence of chronic diseases and utilization for every kind of antihypertensive, antidiabetic, and NSAIDs (measured by self-reported utilization) at baseline and two follow up (2004, 2010, and 2017). Trends were analyzed using Fisher’s exact test.
Results
Hypertension prevalence increased from 19.8 to 30.3%, higher than T2D prevalence from 7.0 to 12.8% through fourteen years of follow-up. Like the self-reported dual therapy, the proportion of patients using beta-blockers and angiotensin II receptor blockers increased. Regarding T2D, the prevalence of metformin utilization increased to 83.9%. The utilization of common NSAIDs, mainly for muscular pain, remained around 13 to 16%.
Conclusions
Our findings showed a changing prevalence of drug utilization for hypertension and T2D between 2004 and 2018 and consistent use of NSAIDs in the adult Mexican population.
A socio-political history of South Africa’s National Health Insurance
Authors: Whyle Eleanor Beth , Olivier Jill 
Published: November 2023

Abstract
Background. Spurred by the WHO’s endorsement of universal health coverage as a universal goal of health systems, many countries are undertaking health financing reforms. The nature of these reforms, and the policy processes by which they are achieved, will depend on context-specific factors, including the history of reform efforts and the political imperatives driving reforms. South Africa’s pursuit of universal health coverage through a National Health Insurance is the latest in a nearly 100-year history of health system reform efforts shaped by social and political realities.
Methods. We conducted an interdisciplinary, retrospective literature review to explore how these reform efforts have unfolded, and been shaped by the contextual realities of the moment. We began the review by identifying peer-reviewed literature on health system reform in South Africa, and iteratively expanded the search through author tracking, citation tracking and purposeful searches for material on particular events or processes referenced in the initial body of evidence. Data was extracted and organised chronologically into nine periods.
Results. The analysis suggests that in South Africa politics; the power of the private sector; competing policy priorities and budgetary constraints; and ideas, values and ideologies have been particularly important in constraining, and sometimes spurring, health system reform efforts. Political transitions and pressures, including the introduction of apartheid in 1948, anti-apartheid opposition, the transition to democracy, and corruption and governance failures, have alternately created political imperatives for reform, and constrained reform efforts. In addition, the country’s political history has given rise to dominant ideas, values and ideologies that imbue health system reform with a particular social meaning. While these ideas and values increase opposition and complicate reform efforts, they also help to expose the inequities of the current system as problematic and re-emphasise the need for reform.
Conclusion. Ultimately, this analysis demonstrates the context-specific nature of health system reform processes and the influence of history on what sorts of reforms are politically feasible and socially acceptable, even in the context of a global push for universal health coverage.
An updated and unified earthquake catalog of Bangladesh for seismic hazard assessment
Authors: Rana Sohel , Bhuiyan M. Abdur Rahman , Ali Shafayat Bin , Mukhlis Mohammad Raihan 
Published: November 2023

Abstract
A comprehensive earthquake catalog is an important input for reliable seismic hazard assessment. In the present study, an updated and unified earthquake catalog has been compiled for Bangladesh covering 150N–320N and 830E–980E. A large number of earthquake event data has been collected from various sources including ISC–GEM Catalog, USGS catalog, ISC Bulletin, etc. Collected data have then been compiled and fake or duplicate events have been eliminated. Earthquake magnitudes that were not reported in moment magnitude (Mw) have been converted to Mw using conversion relations compatible with regional earthquake events. The compiled earthquake catalog consists of 8,024 earthquake events with magnitudes 3.56≤Mw≤8.8 for the period of 825 to 2021. Declustering of the catalog has been performed to remove the foreshocks and aftershocks which results in 7,219 earthquakes in the final catalog. A completeness analysis has been performed for the final catalog. This study proposes Gutenberg-Richter’s earthquake magnitude-frequency relationships for the whole region as well as for five selected regions based on the existing faults within the country. This study provides a database with a solid background for future works in the field of seismicity, seismic hazard assessment, and ground response studies for the country.