bluuebunny/crossref_metadata_2025_split huggingface dataset:
Glutamine Supplementation on Burn Patients: A Systematic Review and Meta-analysis
Authors: Tao Wei , Xu Gang , Zhou Jie , Luo Yi , Li Ping-Song 
Published: January 2024

Abstract
To evaluate the effect of glutamine supplement on patients with burns, we conducted a systematic review and meta-analysis via synthesizing up-to-date studies. Databases including PubMed, Cochrane Central Register, EMBASE, Google scholar, Wanfang data, and ClinicalTrials.gov were searched up to October 2023 to find randomized trials evaluating glutamine supplement on patients with burns. The main outcomes included hospital stay, in-hospital mortality, infection, and wound healing. Twenty-two trials that randomized a total of 2170 patients were included in this meta-analysis. Pooled the length of hospital stay was shortened by glutamine supplement (weighted mean differences [WMD] = −7.95, 95% confidence interval [CI] −10.53 to −5.36, I2 = 67.9%, 16 trials). Both pooled wound healing rates (WMD = 9.15, 95% CI 6.30 to 12.01, I2 = 82.7%, 6 studies) and wound healing times (WMD = −5.84, 95% CI −7.42 to −4.27, I2 = 45.7%, 7 studies) were improved by glutamine supplement. Moreover, glutamine supplement reduced wound infection (risk ratios [RR] = 0.38, 95% CI 0.21 to 0.69, I2 = 0%, 3 trials), but not nonwound infection (RR = 0.88, 95% CI 0.73 to 1.05, I2 = 39.6%, 9 trials). Neither in-hospital mortality (RR = 0.95, 95% CI 0.74 to 1.22, I2 = 36.0%, 8 trials) nor the length of intensive care unit stay (WMD = 1.85, 95% CI −7.24 to 10.93, I2 = 78.2%, 5 studies) was improved by glutamine supplement. Subgroup analysis showed positive effects were either influenced by or based on small-scale, single-center studies. Based on the current available data, we do not recommend the routine use of glutamine supplement for burn patients in hospital. Future large-scale randomized trials are still needed to give a conclusion about the effect of glutamine supplement on burn patients.
The Fundamentals of Inflammatory Bowel Disease Management in Pregnancy: A Practical Review for the Gastroenterologist
Authors: Squirell Elizabeth , Meade Susanna , Leung Yvette 
Published: January 2024

Abstract
This narrative review explores the management of Inflammatory Bowel Disease (IBD) during pregnancy, emphasizing its unique challenges to maternal and fetal health, particularly within the Canadian Gastroenterology setting. Seven key principles are highlighted: 1) Preconception counselling, aiming for steroid-free remission confirmed by objective markers, should be routine for female IBD patients. 2) Medication safety, with an eye to future pregnancies, should be addressed upon initiation. Methotrexate and small molecules are contraindicated during pregnancy, while most 5-ASA therapies, biologics, and thiopurines can be continued throughout pregnancy and breastfeeding. Steroids, though not without risks, can be utilized if necessary. 3) Routine monitoring during remission should include serum biomarkers and fecal calprotectin each trimester. 4) Routine endoscopy and imaging are not required, but if indicated, lower GI endoscopy, ultrasound, and unenhanced MRI can be used. Computed tomography and gadolinium enhanced MRI should be avoided. 5) Caesarean section is advised for patients with previous ileal pouch surgeries or active perianal disease, but other patients should follow obstetric indications for delivery. 6) Postpartum period may see more active disease, requiring continued monitoring. Breastfeeding is encouraged, and routine childhood vaccinations are advised, but live vaccinations in the first 6 months warrant detailed review. 7) Complex IBD patients may benefit from a multidisciplinary approach with robust communication between gastroenterologists and obstetricians.
Habitat heterogeneity limits prey colour polymorphism maintained via negative frequency-dependent selection
Authors: Murali Gopal , Kodandaramaiah Ullasa , Merilaita Sami 
Published: January 2024

Abstract
The persistence of non-neutral trait polymorphism is enigmatic because stabilizing selection is expected to deplete variation. In cryptically coloured prey, negative frequency-dependent selection due to search image formation by predators has been proposed to favour rare variants, promoting polymorphism. However, in a heterogeneous environment, locally varying disruptive selection favours patch type-specific optima, resulting in spatial segregation of colour variants. Here, we address whether negative frequency-dependent selection can overcome selection posed by habitat heterogeneity to promote local polymorphism using an individual-based model. In addition, we compare how prey and predator mobility may modify the outcome. Our model revealed that frequency-dependent predation could strongly promote local prey polymorphism, but only when differences between morphs in patch-specific fitness were small. The effect of frequency-dependent predation depended on the predator adjustment of search image and was hampered by the prey population structure. Gene flow due to prey movement counteracted local selection, promoted local polymorphism to some extent, and relaxed the conditions for polymorphism due to frequency-dependent predation. Importantly, abrupt spatial changes in morph frequencies decreased the probability that mobile frequency-dependent predators could maintain local prey polymorphism. Overall, our study suggests that in a spatially heterogeneous environment, negative frequency-dependent selection may help maintain local polymorphism but only under a limited range of conditions.
Agency in Hierarchies: Middle Managers and Performance Evaluations
Authors: Castro-Pires Henrique 
Published: January 2024

Abstract
This paper studies the optimal joint design of incentives and performance rating scales in a principal-manager-worker hierarchy. The principal wants to motivate the worker to exert unobservable effort at the minimum feasible cost. Given the worker’s effort, two signals are realized: public and verifiable output and a private non-verifiable signal known only to the manager. The principal may try to elicit the manager’s private information by requiring her to evaluate the worker’s performance. Payments may depend on output and the manager’s evaluation. I show that the principal can achieve no more than what is feasible with a binary rating scale. I also identify scenarios where subjective evaluations are valuable (non-valuable), reduced transparency is advantageous, and forced ranking outperforms individual evaluations.
The regulation of health data sharing in Africa: a comparative study
Authors: Nienaber McKay Annelize G , Brand Dirk , Botes Marietjie , Cengiz Nezerith , Swart Marno 
Published: January 2024

Abstract
The sharing of health data is an essential component in the provision of healthcare, in medical research, and disease surveillance. Health data sharing is subject to regulatory frameworks that vary across jurisdictions. In Africa, numerous factors complicate the regulation of health data sharing, including technological, motivational, economic, and political barriers, as well as ethical and legal challenges. This comparative study examines the regulation of health data sharing in Africa by comparing and contrasting the legal and policy frameworks of five African countries. The study identifies gaps and inconsistencies in the current regulatory regimes and provides recommendations for improving the regulation of health data sharing in Africa.
Correlation between tumor size change and outcome in a rare cancer immunotherapy basket trial
Authors: Othus Megan , Patel Sandip P , Chae Young K , Dietrich Eliana , Streicher Howard , Sharon Elad , Kurzrock Razelle 
Published: January 2024

Abstract

Background
RECIST criteria for progressive disease, partial response, and complete response, reflecting +20%, −30%, and −100% tumor size changes, respectively, are critical outcome variables in oncology clinical trials. Herein, we evaluated post-immunotherapy tumor size change correlation with outcomes.

Methods
We used a unique clinical trial data resource, a multicenter basket trial in patients with rare solid tumors treated with nivolumab (anti-PD-1) and ipilimumab (anti-CTLA-4) between 2017 and 2023 (National Cancer Institute/Southwest Oncology Group-sponsored DART trial [NCT02834013]) (open at 1083 sites at its peak). Outcome associations were evaluated by survival analysis techniques including Martingale residuals.

Results
In 638 evaluable patients, we found strong linear relationships between percent change in tumor measurement up to a 40%-50% increase and progression-free (PFS) and overall survival (OS) (both Cox regression P &lt; .001; landmark analyses based on day 65). Pearson R correlation between survival estimates and tumor change category were −0.94, −0.89, and −0.89 (PFS) and −0.84, −0.90, and −0.90 (OS) for median, 6-month (PFS), and 1-year (OS) and for 1-year (PFS) and 2-year (OS) estimates.

Conclusions
Percent change in tumor measurement per RECISTv1.1 (the sum of longest dimensions of target lesions) has a linear association with PFS and OS up to a 40% to 50% increase in tumor measurement in this cohort of patients with rare cancers who received combination immune checkpoint blockade. Quantitative first scan tumor measurement changes include important information to evaluate the potential efficacy of a therapy beyond the proportion of patients who achieve an objective response.
Association between exposure to technological advances in the workplace and work engagement: a prospective cohort study
Authors: Adi Nuri Purwito , Nagata Tomohisa , Odagami Kiminori , Nagata Masako , Mori Koji 
Published: January 2024

Abstract
Objectives: The study objective was to measure the association between exposure to technological advances and work engagement, adjusting for personal and workplace factors.
Methods: We conducted a nationwide online longitudinal survey study in Japan. The sample was stratified to represent Japanese workforce conditions. Work engagement was measured using the Japanese version of the Utrecht Work Engagement Scale-9. Exposure to technological advances was measured using a single question with Likert scale responses. Industry characteristics that were more/less likely to be replaced by automation were also measured. Linear regression was used for statistical analysis.
Results: There were 16 629 participants. We found that exposure to technological advances was associated with work engagement after adjustment for age, sex, education, income, and industry characteristics. We observed a significant interaction between age and exposure to technological advances (coefficient 0.891, P &lt; .001), and conducted an age-stratified linear regression analysis. The significant association between age and exposure to technological advances reduced as age increased, and disappeared after adjustment for baseline work engagement.
Conclusions: Longitudinal observations showed that exposure to technological advances was not significantly associated with work engagement.
Emile’s inquiry-based science education
Authors: Dimopoulou Georgia , Gasparatou Renia 
Published: January 2024

Abstract
Over the past decades, science education researchers have suggested Inquiry-Based Science Education (IBSE) teaching interventions for science classes. In this article, we argue that IBSE’s basic principles can be traced back to Jean-Jacques Rousseau’s work Emile or On Education (1762). First, we will look at IBSE’s rationale. Then we will turn to Emile and outline Rousseau’s educational ideas concerning science education. We will show that Rousseau’s suggested practices for science education are very similar to those of IBSE. Yet despite their vivid similarities, Rousseau seems to pursue epistemic virtues, whilst IBSE aims at epistemic skills. However, nurturing epistemic skills might be seen as the first step for cultivating an epistemically virtuous character. So, embracing Rousseau’s ideal for full character development could further inspire IBSE’s proposals.
Solanine induces ferroptosis in colorectal cancer cells through ALOX12B/ADCY4 molecular axis
Authors: Ma Xudong , Li Yijun , Liang Daoming , Jiang Fan , Zhang Lu , Song Wanhong , Wan Baosheng , Xia Chuqi , Lu Qiyu 
Published: January 2024

Abstract

Objectives
Colorectal cancer (CRC) is the fourth most commonly diagnosed cancer worldwide. Solanine is a phytochemical extracted from traditional Chinese medicine with widely reported anticancer effects. Here, we investigated the potential role of solanine in regulating ferroptosis in CRC cells and scrutinized the molecular mechanism.

Methods
Cell growth and cytotoxicity were examined using CCK-8 proliferation assay and lactate dehydrogenase assay. Oxidative stress was determined by measuring glutathione (GSH), malondialdehyde, and reactive oxygen species (ROS) levels. Subcellular changes in mitochondria were examined by transmission electron microscopy. Gene and protein expression levels were detected by quantitative real-time polymerase chain reaction (qRT-PCR). Protein–protein interaction was determined by co-immunoprecipitation.

Key findings
Solanine arrested cell proliferation in CRC cells and induced typical ferroptotic changes. Solanine treatment promoted ROS production, lipid peroxidation, and cell membrane disruption, while the cellular level of antioxidant GSH was reduced upon solanine treatment. ALOX12B was identified as a molecular mediator of solanine to promote ferroptosis. Solanine treatment upregulated ALOX12B levels and silencing ALOX12B could suppress solanine-induced ferroptosis. Further, ADCY4 was found to physically associate with ALOX12B and maintain ALOX12B protein stability. Silencing ADCY4 destabilized ALOX12B and attenuated solanine-induced ferroptosis.

Conclusions
Our data demonstrated the ferroptosis-inducing effect of solanine in CRC cells, and revealed ALOX12B/ADCY4 molecular axis as the ferroptosis mediator of solanine. Solanine may synergize with existing ferroptosis inducer as an anticancer strategy in CRC, which warrants further validation in animal experiments.
A case of mediastinal hyperparathyromatosis
Authors: Spillane Chloe , Calpin Gavin , Singh Sneha , O’Reilly Kasie , Hehir Cian , Hill Arnold , Magee Colm , Barrett Helen 
Published: January 2024

Abstract
Recurrent hyperparathyroidism (HPT) after initial parathyroid surgery occurs rarely in an ectopic location. The rare phenomenon of parathyromatosis may be the cause of this. We present the case of a 59-year-old woman with recurrent HPT, which presented as a new ectopic mediastinal parathyroid gland 13 years after initial 3.5 gland parathyroidectomy. A 1.5 × 1.3 cm lesion was discovered as an incidental finding in the pretracheal region, closely abutting the aortic arch. An aspirate revealed oncocytic cells, which were positive for parathyroid hormone, confirming a mediastinal parathyroid nodule. Sestamibi scan confirmed an avid nodule in the mediastinum. This patient had multiple co-morbidities but was asymptomatic of HPT. It was therefore decided at multi-disciplinary team discussion that she should undergo surveillance. To our knowledge, no such presentations have been reported in the literature. Thus, our case report is a unique addition of an atypical presentation of HPT.
AC-SLODAR: measuring daytime normalized optical turbulence intensity distribution based on slope autocorrelation
Authors: Ran Xian , Zhang Lanqiang , Rao Changhui 
Published: January 2024

ABSTRACT
In solar observations, the vertical distribution of turbulence can be detected with a multidirectional Shack–Hartmann wavefront sensor, based on SLODAR or S-DIMM+. By expressing the measured cross-correlation as a linear combination of theoretical correlation functions for various height layers, the distribution of turbulence intensity can be obtained through fitting. The theoretical correlation functions in different heights are employed to describe the slope correlation and calculated based on the phase structure function corresponding to classical turbulence statistical theories such as Kolmogorov or von Karman. However, for turbulence that does not obey classical theory, this deviation of the statistical characteristics would result in the measurement accuracy degradation of seeing profiles. A method, so-called AutoCorrelation-SLODAR (AC-SLODAR), is proposed. The feasibility of transforming cross-correlation into autocorrelation is analysed theoretically. Then, the autocorrelation function is calculated based on the actual data to avoid the deviation introduced by the theoretical turbulence statistical model. Extracting statistical characteristics from data also simplifies measurements, without requiring the evaluation of whether the data conforms to a particular classical statistical model. AC-SLODAR was validated with simulation data generated by the open-source emulator SOAPY. The measured error was reduced by 10 per cent compared with SLODAR for the situation of turbulence model deviation. The performance of AC-SLODAR was further compared with those of SLODAR based on the actual data collected in 2016 and 2017 on the New Vacuum Solar Telescope. The corresponding results of AC-SLODAR are consistent with those of SLODAR using a pre-evaluated turbulent model.
Merger-driven multiscale ICM density perturbations: testing cosmological simulations and constraining plasma physics
Authors: Heinrich Annie , Zhuravleva Irina , Zhang Congyao , Churazov Eugene , Forman William , van Weeren Reinout J 
Published: January 2024

ABSTRACT
The hot intracluster medium (ICM) provides a unique laboratory to test multiscale physics in numerical simulations and probe plasma physics. Utilizing archival Chandra observations, we measure density fluctuations in the ICM in a sample of 80 nearby (z ≲ 1) galaxy clusters and infer scale-dependent velocities within regions affected by mergers (r &lt; R2500c), excluding cool-cores. Systematic uncertainties (e.g. substructures, cluster asymmetries) are carefully explored to ensure robust measurements within the bulk ICM. We find typical velocities ∼220 (300) km s−1 in relaxed (unrelaxed) clusters, which translate to non-thermal pressure fractions ∼4 (8) per cent, and clumping factors ∼1.03 (1.06). We show that density fluctuation amplitudes could distinguish relaxed from unrelaxed clusters in these regions. Comparison with density fluctuations in cosmological simulations shows good agreement in merging clusters. Simulations underpredict the amplitude of fluctuations in relaxed clusters on length scales &lt;0.75 R2500c, suggesting these systems are most sensitive to ‘missing’ physics in the simulations. In clusters hosting radio haloes, we examine correlations between gas velocities, turbulent dissipation rate, and radio emission strength/efficiency to test turbulent re-acceleration of cosmic ray electrons. We measure a weak correlation, driven by a few outlier clusters, in contrast to some previous studies. Finally, we present upper limits on effective viscosity in the bulk ICM of 16 clusters, showing it is systematically suppressed by at least a factor of 8, and the suppression is a general property of the ICM. Confirmation of our results with direct velocity measurements will be possible soon with XRISM.
A massive multiphase plume of gas in Abell 2390’s brightest cluster galaxy
Authors: Rose Tom , McNamara B R , Combes F , Edge A C , Russell H , Salomé P , Tamhane P , Fabian A C , Tremblay G 
Published: January 2024

ABSTRACT
We present new ALMA CO(2-1) observations tracing $2.2 \times 10^{10}\, \textnormal {M}_{\odot }$ of molecular gas in Abell 2390’s brightest cluster galaxy, where half the gas is located in a one-sided plume extending 15 kpc out from the galaxy centre. This molecular gas has a smooth and positive velocity gradient, and is receding 250 km s−1 faster at its farthest point than at the galaxy centre. To constrain the plume’s origin, we analyse our new observations alongside existing X-ray, optical, and radio data. We consider the possibility that the plume is a jet-driven outflow with lifting aided by jet-inflated X-ray bubbles, is a trail of gas stripped from the main galaxy by ram pressure, or is formed of more recently cooled and infalling gas. The galaxy’s star formation and gas cooling rate suggest the lifespan of its molecular gas may be low compared with the plume’s age – which would favour a recently cooled plume. Molecular gas in close proximity to the active galactic nucleus is also indicated by 250 km s−1 wide CO(2-1) absorption against the radio core, as well as previously detected CO(1-0) and H i absorption. This absorption is optically thick and has a line-of-sight velocity towards the galaxy centre of 200 km s−1. We discuss simple models to explain its origin.
An ultraviolet spectral study of fullerene-rich planetary nebulae
Authors: Gómez-Muñoz M A , García-Hernández D A , Manchado A , Barzaga R , Huertas-Roldán T 
Published: January 2024

ABSTRACT
Several planetary nebulae (PNe) have been found to contain both polycyclic aromatic hydrocarbon (PAH-like) species and fullerenes (C60) distinguished by their mid-infrared emission. Previous laboratory and astronomical studies suggest that the formation of both species could be related to the decomposition, by photochemical processing, of hydrogenated amorphous carbon (HAC) grains. Then, HACs and, seemingly, big-fullerene related species (e.g. carbon onions) have been suggested as potential carriers of the ultraviolet (UV) bump at 2175 Å and the far-UV rise common to interstellar extinction curves. Our goal is to investigate the UV bump with the possible presence of an HAC extinction component in the International Ultraviolet Explorer (IUE) spectra of C-rich PNe; both with detected and non-detected fullerenes. The considered sample includes three C60-PNe (Tc 1, IC 418, and IC 2501) and the non-C60-PN Hen 2-5. Independently of the presence of C60 in their circumstellar envelopes, we found that the UV bump in all sample PNe is well explained by interstellar extinction, suggesting that species different from those of the foreground interstellar medium, e.g. large fullerene-related species like carbon onions, are not the carrier. Interestingly, we found that PNe Tc 1 and Hen 2-5 show an absorption in the FUV rise. Their IUE continuum spectra may be very well reproduced by including the extinction curve of HAC-like very small grains. The possible presence of both species, HAC-like grains and fullerenes (C60), in Tc 1 could support the HAC photochemical processing scenario for the formation of fullerenes in the complex circumstellar envelopes of PNe.