bluuebunny/crossref_metadata_2025_split huggingface dataset:
Capturing the Range of Disease Involvement in Localized Scleroderma: The Localized Scleroderma Total Severity Scale
Authors: Li Suzanne C. , Rabinovich C. Egla , Becker Mara L. , Torok Kathryn S. , Ferguson Polly J. , Dedeoglu Fatma , Hong Sandy , Sivaraman Vidya , Laxer Ronald M. , Stewart Katie , Ibarra Maria F. , Mason Thomas , Higgins Gloria , Pope Elena , Li Xiaohu , Lozy Tara , Fuhlbrigge Robert C. ,   for the CARRA Registry Investigators
Published: December 2023

ObjectiveJuvenile localized scleroderma (jLS) is a chronic autoimmune disease commonly associated with poor outcomes, including contractures, hemiatrophy, uveitis, and seizures. Despite improvements in treatment, >25% of patients with jLS have functional impairment. To improve patient evaluation, our workgroup developed the Localized scleroderma Total Severity Scale (LoTSS), an overall disease severity measure.MethodsLoTSS was developed as a weighted measure by a consensus process involving literature review, surveys, case vignettes, and multicriteria decision analysis. Feasibility was assessed in larger Childhood Arthritis and Rheumatology Research Alliance groups. Construct validity with physician assessment and inter‐rater reliability was assessed using case vignettes. Additional evaluation was performed in a prospective patient cohort initiating treatment.ResultsLoTSS severity items were organized into modules that reflect jLS disease patterns, with modules for skin, extracutaneous, and craniofacial manifestations. Construct validity of LoTSS was supported by a strong positive correlation with the Physician Global Assessment (PGA) of severity and damage and weak positive correlation with PGA‐Activity, as expected. LoTSS was responsive, with a small effect size identified. Moderate‐to‐excellent inter‐rater reliability was demonstrated. LoTSS was able to discriminate between patient subsets, with higher scores identified in those with greater disease burden and functional limitation.ConclusionWe developed a new LS measure for assessing cutaneous and extracutaneous severity and have shown it to be reliable, valid, and responsive. LoTSS is the first measure that assesses and scores all the major extracutaneous manifestations in LS. Our findings suggest LoTSS could aid assessment and management of patients and facilitate outcome evaluation in treatment studies.image
Temperature‐Dependent Relationship of Autophagy and Apoptotic Signaling During Cold‐Water Immersion in Young and Older Males
Authors: King Kelli E. , McCormick James J. , Kenny Glen P. 
Published: December 2023

AbstractAutophagy is a crucial cytoprotective mechanism preventing the accumulation of cellular damage, especially during external stimuli such as cold exposure. Older adults poorly tolerate cold exposure and age‐related impairments in autophagy may contribute to the associated reductions in cold tolerance. The purpose of this investigation is to evaluate the effect of different intensities of in vivo cold‐water immersion and in vitro cold exposure on autophagic and apoptotic signaling in young and older males. Peripheral blood mononuclear cells (PBMCs) are isolated at baseline, end‐cold exposure, and after 3 h of thermoneutral recovery. Additionally, PBMCs are treated with rapamycin and bafilomycin prior to in vitro cold exposure equivalent to in vivo core temperatures (35–37 °C). Proteins associated with autophagy, apoptosis, the heat shock response, and inflammation are analyzed via Western blotting. Moderate cold stress (0.5 °C decrease in core temperature) increased autophagic and heat shock protein activity while high cold stress (1.0 °C decrease in core temperature) augmented apoptosis in young males. In older males, minimal autophagic activation during both cold‐water exposures are associated with increased apoptotic and inflammatory proteins. Although in vitro cold exposure confirmed age‐related dysfunction in autophagy, rapamycin‐induced stimulation of autophagic proteins underlie the potential to reverse age‐related vulnerability to cold exposure.
Asymmetric Coordination of Iron Single‐Atom Nanozymes with Efficient Self‐Cascade Catalysis for Ferroptosis Therapy
Authors: Liu Wendong , Chen Qian , Wu Jiaxin , Zhang Fanghua , Han Lu , Liu Jia , Zhang Hongyan , Hao Zhe , Shi Enyu , Sun Yuzhu , Zhang Ruizhong , Wang Yinsong , Zhang Libing 
Published: December 2023

AbstractSingle‐atom nanozymes (SAzymes) hold great promise in tumor therapy due to their maximized atomic utilization and well‐defined electronic structures. However, they still face challenges of activity, specificity, and targeting that impede therapeutic efficacy. Herein, a practical strategy is reported to construct asymmetric N, S‐coordinated Fe SAzymes (Fe‐S/N‐C). Benefiting from the regulatory influence of S atoms on the disruption of local charge symmetry of center Fe atoms, the Fe‐S/N‐C SAzymes exhibit significantly enhanced peroxidase (POD)‐ and glutathione oxidase (GSHOx)‐like activities, with catalytic efficiencies being 6.33 and 47.88 times higher than their symmetric Fe‐N4 counterparts, respectively. Theoretical calculations demonstrate that the asymmetric atomic interface configuration increases electron localization around center Fe sites, thus facilitating the adsorption and activation of H2O2 and O2. By camouflaging with macrophage membranes, the tumor‐targeting nanocatalytic agents (M@Fe‐S/N‐C) trigger enhanced self‐cascade catalysis in the tumor microenvironment for ferroptosis‐based tumor‐specific therapy. These results open up a promising avenue for addressing the limitations associated with current SAzymes‐based tumor therapies.
Heterogeneous Cobalt Phthalocyanine/Sulfur‐Modified Hollow Carbon Sphere for Boosting CO2 Electroreduction and Zn–CO2 Batteries
Authors: Wang Huijie , Zhu Jiaye , Ren Xuhui , Tong Yun , Chen Pengzuo 
Published: December 2023

AbstractTuning coordination environment of single‐atom catalysts (SACs) is widely applied for the electrochemical CO2 reduction reaction (CO2RR). However, the influence of the interaction between SACs and support on the catalytic performance are not comprehensive. Herein, taking cobalt phthalocyanine (CoPc) as a conceptual example, a hetero S‐atom doping strategy of hollow carbon sphere (S‐NHC) is put forward as a carrier, revealing the intrinsic relationship between microenvironment regulation and catalytic activity of single Co‐atom. The additional S doping may induce more carbon defect and increases the content of pyrrolic N in the S‐NHC sample, leading to stronger electronic interaction of heterogeneous CoPc/S‐NHC for boosting CO2RR performance. Remarkably, the catalyst achieves a highest CO selectivity of nearly 100% at −0.6 V, and the FECO are over 90% in a wide potential range from −0.4 to −0.8 V in a flow cell. The maximum power density is high as 2.68 mW cm−2 at 4.7 mA cm−2 for the Zn–CO2 battery with CoPc/S‐NHC cathode. In situ attenuated total reflection infrared (ATR‐IR) spectroscopy reveals the formation of key *COOH and *CO intermediates, while the calculation result confirm the optimized Gibbs free energy of these intermediates on CoPc/S‐NHC, suggesting the feasibility of the regulation strategy.
Revealing the Accelerated Capacity Decay of a High‐Voltage LiCoO2 upon Harsh Charging Procedure
Authors: Li Zijian , Yi Haocong , Ding Wangyang , Ren Hengyu , Du Yuhao , Shang Mingjie , Zhao Wenguang , Chen Hui , Zhou Lin , Lin Hai , Zhao Qinghe , Pan Feng 
Published: December 2023

AbstractIn practical applications, LiCoO2 (LCO) cathode is usually charged with a constant current plus constant voltage (CC+CV) procedure to obtain higher capacity delivery. However, the harsh condition upon CC+CV procedure causes the accelerated capacity decay of LCO. Herein, the fading mechanism of LCO cycling upon CC+CV procedure at 4.6 V versus Li/Li+ is first revealed. Comparing with a pure CC charging, the accelerated capacity decay of LCO upon CC+CV procedure is attributed to both the bulk and surface structure damages: i) the CV charging triggers more H1‐3 phase separation, leading to the generation of lattice dislocations, curved Co‐O layers, and ultimately the bulk microcracks inside the LCO particles; ii) upon cycle, the CV charging causes more side reactions and more surface structure collapse issues, including forming thick surface phase transition layer (PTL), causing more Co dissolution, forming thick and loose CEI layer, etc., which seriously increases the charge transfer resistance and reduces the interface Li+ transport kinetics. This work provides a new insight into the fading mechanism, and shows a new pathway for designing more advanced LCO cathodes.
Strong and Tough Biofibers Designed by Dual Crosslinking for Sutures
Authors: Xiao Yao , Yang Ze , Guo Baoling , Wu Baiheng , Liu Rongrong , Zhang Shikai , Zhao Peng , Ruan Jian , Lu Xingyu , Liu Kai , Chen Dong 
Published: December 2023

AbstractHigh‐performance bio‐based fibers have unique advantages in biocompatibility for biomedical applications, such as sutures, hernia patches, and blood vessels. Herein, strong and tough biofibers based on regenerated silk fibroins (RSFs) are designed by a dual‐crosslinking strategy and prepared continuously in situ via a single‐channel microfluidic device. During the wet spinning process, covalent bonds between tyrosines are introduced by photo crosslinking and coordination interactions of Zn2+ ions with serines are built between RSFs, forming a dual‐crosslinked, and inter‐connected network and effectively improving the mechanical performances of RSF fibers. By optimizing the wet spinning parameters and applying an optimal post‐stretching treatment, dual‐crosslinked RSF fibers exhibit an excellent tensile strength of 891 MPa, a remarkable Young's modulus of 15.0 GPa, a large tensile strain of 20.1%, and an outstanding toughness of 114 MJ m−3, which are superior to other regenerated biofibers. In addition to the outstanding mechanical performances, dual‐crosslinked RSF fibers also possess excellent temperature adaptability, fatigue resistance, biocompatibility, and biodegradability, making them ideal candidates for biomedical applications. In vivo tests of dual‐crosslinked RSF fibers as sutures demonstrate a good wound healing performance with smaller scar and lower inflammation.
Polysiloxane Inks for Multimaterial 3d Printing of High‐Permittivity Dielectric Elastomers
Authors: Danner Patrick M. , Pleij Tazio , Siqueira Gilberto , Bayles Alexandra V. , Venkatesan Thulasinath Raman , Vermant Jan , Opris Dorina M. 
Published: December 2023

AbstractDielectric elastomer transducers (DET) are promising candidates for electrically‐driven soft robotics. However, the high viscosity and low yield stress of DET formulations prohibit 3D printing, the most common manufacturing method for designer soft actuators. DET inks optimized for direct ink writing (DIW) produce elastomers with high stiffness and mechanical losses, diminishing the utility of DET actuators. To address the antagonistic nature of processing and performance constraints, principles of capillary suspensions are used to engineer DIW DET inks. By blending two immiscible polysiloxane liquids with a filler, a capillary ink suspension is obtained, in which the ink rheology can be tuned independently of the elastomer electromechanical properties. Rheometry is performed to measure and optimize processibility as a function of filler and secondary liquid fraction. Including polar polysiloxanes as the secondary liquid produces a printed elastomer exhibiting a four‐fold permittivity increase over commercial polydimethylsiloxane. The characterization and multimaterial printing into layered DET devices demonstrates that the immiscible capillary suspension improves the processability of the inks and enhances the properties of the elastomers, enabling actuation of the devices at comparatively low voltages. It is anticipated that this formulation approach will allow soft robotics to harness the full potential of DETs.
Microarchitected Compliant Scaffolds of Pyrolytic Carbon for 3D Muscle Cell Growth
Authors: Taale Mohammadreza , Schamberger Barbara , Monclus Miguel A. , Dolle Christian , Taheri Fereydoon , Mager Dario , Eggeler Yolita M. , Korvink Jan G. , Molina‐Aldareguia Jon M. , Selhuber‐Unkel Christine , Lantada Andrés Díaz , Islam Monsur 
Published: December 2023

AbstractThe integration of additive manufacturing technologies with the pyrolysis of polymeric precursors enables the design‐controlled fabrication of architected 3D pyrolytic carbon (PyC) structures with complex architectural details. Despite great promise, their use in cellular interaction remains unexplored. This study pioneers the utilization of microarchitected 3D PyC structures as biocompatible scaffolds for the colonization of muscle cells in a 3D environment. PyC scaffolds are fabricated using micro‐stereolithography, followed by pyrolysis. Furthermore, an innovative design strategy using revolute joints is employed to obtain novel, compliant structures of architected PyC. The pyrolysis process results in a pyrolysis temperature‐ and design‐geometry‐dependent shrinkage of up to 73%, enabling the geometrical features of microarchitected compatible with skeletal muscle cells. The stiffness of architected PyC varies with the pyrolysis temperature, with the highest value of 29.57 ± 0.78 GPa for 900 °C. The PyC scaffolds exhibit excellent biocompatibility and yield 3D cell colonization while culturing skeletal muscle C2C12 cells. They further induce good actin fiber alignment along the compliant PyC construction. However, no conclusive myogenic differentiation is observed here. Nevertheless, these results are highly promising for architected PyC scaffolds as multifunctional tissue implants and encourage more investigations in employing compliant architected PyC structures for high‐performance tissue engineering applications.
Photothermal and Photocatalytic Glycol Chitosan and Polydopamine‐Grafted Oxygen Vacancy Bismuth Oxyiodide (BiO1‐xI) Nanoparticles for the Diagnosis and Targeted Therapy of Diabetic Wounds
Authors: Kong Jianglong , Ma Sihan , Chu Runxuan , Liu Jiawen , Yu Hongrui , Mao Meiru , Ge Xiaohan , Sun Yuting , Wang Yi 
Published: December 2023

AbstractTreatment of diabetic wounds is a significant clinical challenge due to the massive infections caused by bacteria. In this study, multifunctional glycol chitosan and polydopamine‐coated BiO1‐xI (GPBO) nanoparticles (NPs) with near‐infrared (NIR) photothermal and photocatalytic abilities are prepared. When infection occurs, the local microenvironment becomes acidic, and the pH‐switchable GPBO can target the bacteria of the wound site. The NIR‐assisted GPBO treatment exhibits anti‐bacterial effects with fast response, high efficiency, and long duration to Escherichia coli, Pseudomonas aeruginosa, and Staphylococcus aureus. GPBO achieves excellent photothermal imaging and CT imaging of the mouse subcutaneous abscess model. With the assistance of NIR irradiation, the GPBO promotes the healing of the diabetic wound model with the effects of anti‐bacteria, anti‐inflammation, the M2 polarization promotion of macrophages, and angiogenesis. This is the first‐time report of nano‐sized BiO1‐xI. The synthesis and selected application for the imaging and targeted therapy of diabetic wounds are presented. This study offers an example of the NP‐assisted precise diagnosis and therapy of bacterial infection diseases.
Cross Relaxation Enables Spatiotemporal Color‐Switchable Upconversion in a Single Sandwich Nanoparticle for Information Security
Authors: Huang Jinshu , Yan Long , An Zhengce , Wei Haopeng , Wang Chao , Zhang Qinyuan , Zhou Bo 
Published: December 2023

AbstractSmart control of ionic interaction dynamics offers new possibilities for tuning and editing luminescence properties of lanthanide‐based materials. However, it remains a daunting challenge to achieve the dynamic control of cross relaxation mediated photon upconversion, and in particular the involved intrinsic photophysics is still unclear. Herein, this work reports a conceptual model to realize the color‐switchable upconversion of Tm3+ through spatiotemporal control of cross relaxation in the design of NaYF4:Gd@NaYbF4:Tm@NaYF4 sandwich nanostructure. It shows that cross relaxation plays a key role in modulating upconversion dynamics and tuning emission colors of Tm3+. Interestingly, it is found that there is a short temporal delay for the occurrence of cross relaxation in contrast to the spontaneous emission as a result of the slight energy mismatch between relevant energy levels. This further enables a fine emission color tuning upon non‐steady state excitation. Moreover, a characteristic quenching time is proposed to describe the temporal evolution of cross relaxation quantitatively. These findings present a deep insight into the physics of ionic interactions in heavy doping systems, and also show great promise in frontier applications including information security, anti‐counterfeiting and nanophotonics.
Synthesis of Pigmented Parylene Coatings and Control of the Chromatism Based on Chemical Vapor Deposition Copolymerization
Authors: Wu Ting‐Ying , Chuang Chih‐Peng , Chou Fang‐Yu , Chiang Yu‐Chih , Jhang Jia‐Rong , Guan Zhen‐Yu , Chiu Chih‐Hao , Huang Sheng‐Tung , Wu Chen‐Chi , Chen Hsien‐Yeh 
Published: December 2023

AbstractColoring and identification procedures for medical devices are important to reduce the risks of defective medical devices or incorrect operations and implantations. The study herein reports a novel platform of color pigment‐modified Parylene coatings to fulfill the needs of medical coatings, providing a surface modification route to alter the important property of color for an underlying material and/or device from its original color. Modification with a naphthalimide derivative is employed for the Parylene precursor. The synthesis of the final color Parylene coating is performed based on a vapor‐phase deposition polymerization process, and the coating is conformally coated on a variety of materials regardless of the shape or dimension. Furthermore, control of the color to create a series of color‐changing Parylene coatings is enabled by vapor deposition copolymerization with a second Parylene derivative source, and predictable color tuning from a primary to a secondary and/or tertiary color is achievable in the experiments and shows accordance with color theory. The reported coating platform represents a colored coating tool and is biocompatible for biotechnological applications.
Wearable MXene‐Graphene Sensing of Influenza and SARS‐CoV‐2 Virus in Air and Breath: From Lab to Clinic
Authors: Li Yanxiao , Peng Zhekun , Li Jiaoli , Wei Congjie , Liu Shangbin , Hao Weixing , Cheng Huanyu , Burton Casey , Wang Yang , Huang Yue‐Wern , Kim Chang‐Soo , Hou Fang Yao Stephen , Kim DongHyun , Wu Chenglin 
Published: December 2023

AbstractThe rapidly expanding severe acute respiratory syndrome coronavirus 2 (SARS‐CoV‐2) and its variants demand a continuous monitoring method through portable and wearable devices. Utilizing the rich surface chemistry and high chemical‐to‐electrical signal conversion of 2D MXene‐graphene heterostructure thin films, a field‐effect‐transistor (FET) sensor, which has a flexible substrate to be assembled onto the mask and combines with a Bluetooth system for wireless transmission is developed, to detect the influenza and SARS‐CoV‐2 viruses in air and breath. At first, the developed sensors are examined in the laboratory through direct contact with sensing targets in solution form. The results show a low limit of detection (LOD) of 1 fg mL−1 for recombinant SARS‐CoV‐2 spike protein and 125 copies mL−1 for inactivated influenza A (H1N1) virus with high specificity in differing recombinant SARS‐CoV‐2 spike protein and inactivated H1N1 virus. Then the sensors are tested under various simulated human breathing modes through controlled exposure to atomizer‐generated aerosols in an enclosed chamber and mask coverage. The results show the high sensitivity of the developed sensors under varying distances to the source, viral load, flow rate, and enclosed conditions. At last, clinical tests are carried out to demonstrate the robustness and potential field applications of the sensors.
Developing Porous Microneedles Patch for the Detection of Wound Infections
Authors: Xue Wenjing , Na Jintong , Zhang Lexiang , Zu Yan , Lin Faquan 
Published: December 2023

AbstractWound infections caused by invasive pathogens become an increasing global challenge health. Porous microneedles (MNs) present distinctive advantages for non‐invasive and in situ detection of wound infections, enabling the extraction of interstitial fluid, skin sweat, saliva and other biological samples. Consequently, porous MNs find widespread acceptance in medical detection, drug delivery, and monitoring physiological indicators. Based on these advantages, the emerging clinical applications and classifications of MNs is first introduced, covering mechanical strength, methods for antibody probe modification onto porous MNs, and signal amplification techniques for biomarkers analysis. At the same time, the specific applications of immunology and electrochemistry on porous MNs, introducing methods to enhance the detection signal of target molecules, such as rolling circle amplification, gold/silver nanoparticles, fluorescence amplification origami microneedle and so on is try to summarized. The improvement of detection sensitivity is realized by integrating various signal amplification strategies and diverse detection methods. Meanwhile, it is briefly illustrated applications in wound detections. Finally, challenges and future prospects of using porous MNs for detection in practical applications is discussed.
Rational Design of Circularly Polarized Luminescent Molecular Structures Toward NIR and Single Molecule White Light Emission
Authors: Liu Jianxun , He Tengfei , Gong Zhong‐Liang , Liang Ning , Feng Yansong , Long Guankui , Zhong Yu‐Wu , Yao Chang‐Jiang 
Published: December 2023

AbstractSingle‐molecule white‐light and near‐infrared circularly polarized luminescent materials are effective complements to the demonstrated enhancements of visible emission in the high contrast 3D images or organic light‐emitting diodes. In this contribution, two binaphthalene‐containing luminogenic enantiomers (BIT or BITM) with aggregation‐induced emission are synthesized which exhibit circularly polarized luminescence in solution with dissymmetry factors of ±5.0 × 10−3 and ±4.8 × 10−3, respectively. Additionally, the dual‐fluorescence spectra of single‐molecule white emission (CIE: 0.33, 0.34) in toluene solution are observed with (R)/(S)‐BIT in low polarity solvent originating from locally excited and twisted intramolecular charge‐transfer emission. While (R)/(S)‐BITM only shows single NIR luminescence with peaks at 720 nm in powder state. The nondoped OLEDs exhibit high maximum external quantum efficiencies of up to 4.2% with small efficiency roll‐off and NIR electroluminescence peak at 709 nm.