bluuebunny/crossref_metadata_2025_split huggingface dataset:
EDUKASI DAN PROGRAM VITAMIN D DALAM PENCEGAHAN OSTEOPOROSIS
Authors: Karim Ulfah Nuraini , Dewi Aliana 
Published: October 2023

Osteoporosis adalah penyakit pengeroposan tulang yang banyak diderita oleh kalangan lanjut usia, terutama wanita. Upaya pencegahan Osteoporosis di Indonesia sudah dilakukan dengan peningkatan asupan kalsium termasuk vitamin D, dimana Vitamin D merupakan salah satu zat gizi yang penting untuk tulang. Tujuan dari kegiatan pengabdian masyarakat ini memberdayakan masyarakat untuk menjaga asupan kalsium termasuk vitamin D selalu adekuat sehingga membantu mengurangi resiko Osteoporosis. Metode yang digunakan pada pengabdian masyarakat ini berupa partisipasi masyarakat dengan indikator kesertaan masyarakat dalam kegiatan melalui sosialisasi dan pelatihan yang dilakukan secara offline. Hasil dari kegiatan ini berupa sediaan asupan kalsium termasuk vitamin D yang dapat dimanfaatkan oleh masyarakat dalam hal pemenuhan kebutuhan nutrisi untuk pencegahan Osteoporosis, sehingga kesehatan masyarakat meningkat.
Kata kunci: Osteoporosis, edukasi, program vitamin D.

ABSTRACT
Osteoporosis is a disease of bone loss that affects many elderly people, especially women. Efforts to prevent osteoporosis in Indonesia have been carried out by increasing calcium intake, including vitamin D, where vitamin D is an important nutrient for bones. The purpose of this community service activity is to empower the community to maintain adequate intake of calcium including vitamin D so as to help reduce the risk of osteoporosis. The method used in community service is in the form of community participation with indicators of community participation in activities through outreach and training which are conducted offline. The results of this activity are in the form of preparations for calcium intake including vitamin D which can be utilized by the community in terms of meeting nutritional needs for the prevention of Osteoporosis, so that public health improves.
Keywords: Osteoporosis, Education, Vitamin D Program.
Vaginal Uncomplicated Delivery Rate as a Quality Indicator Compared to Cesarean Delivery Rate: A Quantitative Analysis of a Population Database
Authors: Cundiff Geoffrey W. , Kaur Paramdeep , Hanley Gillian E. , Janssen Patti 
Published: October 2023

Abstract
Background:
Cesarean Delivery rate is a commonly used performance indicator to assess the quality of maternity care, and yet efforts to objectively define the optimal rate have foundered. The Vaginal Uncomplicated Delivery rate was developed as an alternative approach. The Vaginal Uncomplicated Delivery includes all vaginal deliveries, without an adverse labour outcome, whether or not forceps or vacuum were used. By assessing both mode of delivery as well as the absence of maternal and neonatal adverse delivery outcomes, it combines process and outcomes. The objective of this study was to assess the Vaginal Uncomplicated Delivery rate as performance indicator, compared to the Cesarean Delivery rate.
Methods:
This is a retrospective cohort analysis of a higher risk obstetrical population drawn from the British Columbia Perinatal Data Registry, including all term deliveries by an obstetrician in 2015 in British Columbia, Canada. We excluded proscriptions for active labour, specifically transverse lie, active herpes, placenta previa, and vasa previa. Most obstetricians in this jurisdiction practice consultative obstetrics, focused on supporting primary maternity care. We investigated the association of Adverse Delivery with Cesarean Delivery and Vaginal Uncomplicated Delivery rates.
Results:
We report 16,620 deliveries by 210 obstetricians, with a vaginal delivery rate of 39.6%, of which 36.6% were operative vaginal delivery. The overall Adverse Delivery rate was 9.9%, and the overall Vaginal Uncomplicated Delivery rate was 34%. While the Cesarean Delivery and Vaginal Uncomplicated Delivery by definition were correlated with mode of delivery, only the Vaginal Uncomplicated Delivery rate was correlated to the Adverse Delivery rate.
Conclusions:
Quality assurance in obstetrics must balance the needs of two patients based on limited data. Our data suggest that the prevailing performance indicator, Cesarean Delivery rate, fails in this respect because, it does not correlate with birth outcomes for the pregnant patient or infant. The Vaginal Uncomplicated Delivery rate, provides an alternative that correlates with both mode of delivery as a traditional indicator and labour outcomes. Shifting the quality lens to focus on Vaginal Uncomplicated Delivery rate will provide a better metric that measures optimal outcomes for pregnant people, and their babies.
Clinical analysis of 23 cases of neonatal Omicron (a variant of SARS-CoV-2) infection in Suzhou
Authors: Zhang Jie , Ma Yan , Xu Liang , Ji Yiding , Gu Lan 
Published: October 2023

Abstract

Objective
To analyze the clinical characteristics of neonatal cases of severe acute respiratory syndrome coronavirus 2 (SARS‑CoV‑2) infection in Suzhou since December 2022.
Methods
In this retrospective case series study, the clinical data of 23 neonates with SARS-CoV-2 infection at our hospital from December 10, 2022, to January 10, 2023, were collected, and the epidemiological history, clinical manifestations and outcomes, laboratory changes, etc., were analyzed.
Results
Among the 23 infants, there were 9 males and 14 females, 22 full-term infants, and 1 premature infant (35 weeks+ 1). The oldest was 27 days old, and the youngest was premature. Age at diagnosis was 14(9.0,19.0) days. The mothers were all prenatally diagnosed with coronavirus disease 2019 (COVID-19). All 22 full-term infants lived with their mothers in the same room. Among them, 8 were exclusively breastfed, 14 were mixed-fed, and 1 was a preterm infant who was not breastfed. Twenty-two neonates were infected by horizontal transmission, and 1 was infected by suspected vertical transmission from mother to child. The clinical classification included 1 asymptomatic infection, 20 mild infections, 2 moderate infections. The most common clinical manifestations were fever (21 neonates), and the fever duration was 1–6 days. Other clinical manifestations included respiratory symptoms(18 neonates), digestive tract symptoms(12 neonates) and abdominal distension (2 neonates). Neurological symptoms included mild drowsiness, irritability, and crying (3 neonates). The other symptoms included 4 cases of jaundice and 2 cases of rash. The white blood cell count was lower than 4.0*109/L in 1 neonate. The lymphocyte count was lower than 1.0*109/L in 1 neonate. Interleukin-6 was normal in 3 neonates, slightly elevated in 11 neonates, and greater than 200 pg/ml in 2 neonates. Procalcitonin was slightly elevated in 1 neonate. The creatine phosphokinase isoenzyme (CK-MB) was slightly elevated in 4 neonates. Two neonates had flocculent high-density shadows in chest X-ray. 21 patients were cured and discharged, while another 2 patients were discharged after improvement; the length of hospitalization was 3.8 (4.0,5.0)days. Twenty-one patients were followed up and no repeated clinical manifestations were reported.
Conclusion
SARS-CoV-2 infection in neonates in this area was mainly transmitted horizontally and mainly mild cases, with mild clinical symptoms and mildly increased inflammatory indicators. The short-term prognosis was good.
Deciphering the Influence of AP1M2 in Modulating Hepatocellular Carcinoma Growth and Mobility through JNK/ErK Signaling Pathway control
Authors: Wang Huan , Xie Xin , Du Minwei , Wang Xintong , Wang Kunyuan , Chen Xingyuan , Yang Hui 
Published: October 2023

Abstract
Background
HCC is the most common digestive system malignancy, with unclear pathogenesis and low survival rates. AP1M2 is associated with tumor progression, but its role and molecular mechanisms in HCC remain poorly understood and require further investigation.
Methods
We utilized the Gene Expression Omnibus (GEO) and Expression Analysis Interactive Hub (XENA) databases to assess AP1M2 mRNA expression levels in HCC patients. Additionally, we employed the Cancer Genome Atlas (TCGA) database to identify pathways associated with both AP1M2 and HCC development. To evaluate the effect of AP1M2 on hepatocellular Carcinoma cell proliferation and migration, we employed various techniques including EdU, CCK8, Colony formation assay, and Transwell assays. Furthermore, Western blot analysis was conducted to examine the signaling pathways influenced by AP1M2.
Results
AP1M2 expression was significantly increased at the mRNA level in HCC tissues(P < 0.001). Importantly, overall survival (OS) analysis confirmed the association between higher AP1M2 expression and a poorer prognosis in HCC patients compared to those with lower AP1M2 expression (P < 0.019).Multivariate Cox regression analysis showed that AP1M2 was an independent prognostic factor and a valid predictor for HCC patients. Furthermore, GSEA results indicated differential enrichment of lipid, bile acid, metal metabolism, and coagulation processes in HCC samples demonstrating a high AP1M2 expression phenotype. In vitro experiments supported these findings by demonstrating that AP1M2 promotes HCC cell proliferation and migration, while activating the JNK/ERK pathway.
Conclusion
Our findings indicate that AP1M2 expression may serve as a potential molecular marker indicating a poor prognosis for HCC patients. Furthermore, we have demonstrated that AP1M2 significantly influences HCC cell proliferation and migration, with the JNK/ERK signaling pathway playing a key role in AP1M2-mediated regulation in the context of HCC.
The Leicester, Leicestershire and Rutland Integrated Chronic Kidney Disease (iCKD) System Programme: Implementation within a Primary Care Network
Authors: Rizvi Fahad , Lakhani Niraj , Omuri Lydia , Roshan Simran , Kapasi Tariq , Wilson Philippe B. , White Samuel J 
Published: October 2023

Abstract

Background: The optimisation of patients in primary care is a prime opportunity to manage patient care within the community and reduce the burden of referrals on secondary care. Herein we report a quality improvement clinical programme taking place within an NHS Primary Care Network as part of the wider Leicester Leicestershire Rutland integrated chronic kidney disease programme.
Method: Patients are optimised to guidelines from the National Institute for Health and Care Excellence, supported by a primary care clinical team who are in turn supported by nephrology consultants and nephrology pharmacists. The secondary care specialists undertake monthly multidisciplinary team meetings with the primary care staff where learning is passed to the community clinicians for better patient treatment locally.
Results: A total of 526 patients were reviewed under this project and following upskilling of the local clinician team in nephrology and medicine management, the total number of referrals to secondary care which were discharged following first outpatient appointment reduced from 42.9% to 10%. This reduction of 32.9% represents the sifting and optimisation of patients cases through this quality improvement programme by allowing many patients to be optimised and managed within the community and reducing the number of unnecessary referrals to secondary care, instead referring the difficult and complex cases which benefit the most from care within the Trust.
Conclusion: This programme has the potential to offer significant improvement in patient outcomes when expanded to a larger patient base, whilst optimising both the medicine management and the use of clinical staff in both primary and secondary care.
Synergistic effect of nano strontium titanate (SrTiO3) coating and ultraviolet C photofunctionalization on osteogenic performance and soft tissue sealing of poly (ether-ether-ketone) (PEEK)
Authors: Chen Tianjie , Jinno Yohei , Atsuta Ikiru , Tsuchiya Akira , Obinata Sora , Iimori Riku , Kimura Takashi , Ayukawa Yasunori 
Published: October 2023

Abstract
Background

Poly (ether-ether-ketone) (PEEK) is regarded as a potential dental implant material. However, PEEK’s biological inertness hinders its osseointegration and soft tissue sealing properties, thereby limiting the application of PEEK. Therefore, this study aimed to evaluate the bioactivity of PEEK after surface modification by persistent photoconductive strontium titanate (SrTiO3) magnetron sputtering and ultraviolet (UV) C irradiation.

Methods

According to the different modification, the PEEK specimens were randomly divided into five groups (n = 38/group): PEEK, Sr100-PEEK, Sr200-PEEK, UV/PEEK, and UV/Sr200-PEEK. Then, the specimens of Sr100-PEEK and Sr200PEEK groups were respectively coated with 100 nm and 200 nm thickness photocatalyst SrTiO3 on the PEEK surface by magnetron sputtering. Subsequently, UV-C light was photofunctionalized the specimens of PEEK and Sr200-PEEK groups to form UV/PEEK and UV/Sr200-PEEK groups. The specimens were characterized by a step meter, scanning electron microscopy (SEM), atomic force microscopy
(AFM), energy dispersive X-Ray spectroscopy (EDX) and a water contact angle meter. The release test of Sr ion was performed by inductively coupled plasma mass spectrometry (ICP-MS). In vitro study, osteogenic activity (MC3T3-E1 osteoblast-like cells) and epithelial and connective tissue attachment (gingival epithelial cells GE1 and fibroblasts NIH3T3) were analyzed in five groups.

Results

Surface morphology of the specimens was changed after coating and the Sr content on the Sr-PEEK surface was increased with increasing coating thickness. In addition, the contact angle was increased significantly after magnetron sputtering. After UV-C photofunctionalization, the content of surface elements has changed and the contact angle was decreased. The release of Sr ion was sustained and the final cumulative release amount did not exceed the safety limit. In vitro experiments showed that SrTiO3 improved the cell activity of MC3T3-E1, UV-C irradiation further enhanced the osteogenic performance of PEEK. Besides, UV-C irradiation also significantly promoted the cell viability, development and expression of adhesion proteins of GE1 and NIH3T3 on PEEK.

Conclusions

The present investigation demonstrated that nano SrTiO3 coating with UV-C photofunctionalization synergistically enhanced the osteogenic properties and soft tissue sealing function of PEEK in vitro.
Analysis of the incidence and influencing factors of abdominal distension in postoperative lung cancer patients in ICU based on real-world data: A retrospective cohort study
Authors: Liu Yan , Tang Tingting , Wang Chunyan , Wang Chunmei , Zhu Daxing 
Published: October 2023

Abstract
Background: Abdominal distension is a relatively common complication in postoperative lung cancer patients, which affects patients' early postoperative recovery to varying degrees. However, the current status of the incidence of abdominal distension in postoperative lung cancer patients and the affecting factors are not well understood. This study aims at exploring the incidence of abdominal distension in postoperative lung cancer patients in ICU based on real-world data and analyzing its influencing factors.
Methods : A retrospective cohort study was conducted, included in which were patients who underwent surgical resections in lung cancer center of West China Hospital of Sichuan University between April 1, 2020 and April 30, 2021. Nevertheless, patients younger than 18 years and those whose information was limited in medical records were excluded. All data were obtained from the hospital HIS system. In this study, the influencing factors of abdominal distension were analyzed by univariate analysis and multiple logistic regression methods.
Results: A total of 1317 patients met eligibility criteria, and were divided into the abdominal distended group and the non-distended group according to whether abdominal distension occurred after surgery. Abdominal distension occurred in a total of 182 cases among them, whose proportional value was 13.8%. The results of the univariate analysis showed that, compared with the non-distended group, the abdominal distended group had these features as follows: more women (P=0.021), younger age (P=0.000), lower BMI (P=0.000), more patients with open thoracotomy (P=0.000), more patients with neoadjuvant chemotherapy (P=0.000), more days of hospitalization on average (P=0.000), and higher costs of hospitalization on average (P=0.032). Multifactor logistic regression analysis showed that sex (OR=0.521; 95% CI=0.376～0.722) and surgical methods (OR=3.874; 95%CI=2.731～5.534) were independent influencing factors for the occurrence of abdominal distension in patients after lung cancer surgery in ICU.
Conclusions: The incidence of abdominal distension was higher in postoperative lung cancer patients in ICU, and female patients and patients with open thoracotomy were more likely to have abdominal distension.
Trial registration:The study was approved by the Chinese Clinical Trials Registry (registration number was ChiCTR2200061370).
Development and validation of clinical predictive models for differentiated thyroid carcinoma and cervical lymph node metastasis: A retrospective cohort study
Authors: Chen Xiao , Wang Han-yu , Lu Qing , Wang Yu , Hu Qin-yu , Sun Hui 
Published: October 2023

Abstract

Background: For differentiated thyroid carcinoma (DTC), the main negative prognostic factor is
cervical lymph node metastasis (CLNM). Two clinical prediction models were established based on the preoperative characteristics of thyroid nodules to provide a more individualized guidance for predicting DTC and CLNM.
Methods: Altogether, 679 hospitalized patients with DTC and 294 patients with benign thyroid nodules were retrospectively included, and patients with DTC were further distinguished as having CLNM. Two multiple logistic regression models were established in this retrospective cohort. The considered predictors mainly included ultrasound features of thyroid nodules and lymph nodes, as well as clinical characteristics, including body mass index, age, sex, and thyroid-related laboratory parameters. All cases were used as a training set and internally validated using bootstrap resampling.
Results: The receiver operating curve (ROC) of the model for diagnosing benign and malignant thyroid nodules corresponded to an area under the curve (AUC) of 0.873 in the training set and a Brier score of 0.116 for calibration. After bootstrap internal validation, the adjusted AUC was 0.858, and the Brier score was 0.122. The model had better performance than the only ultrasound grading for diagnosing DTC. The ROC of the model for predicting CLNM had an AUC value of 0.745 in the training set, and the Bbrier score was 0.203. After bootstrap internal validation, the adjusted AUC value was 0.720, and the Brier score was 0.214.
Conclusion: The two clinical prediction models have good predictive efficacy for diagnosing DTC and assessing its metastasis, providing new diagnostic tools.
Unprecedented insights into extents of biological responses to physical forcing in an Arctic sub-mesoscale filament by combining high-resolution measurement approaches
Authors: Weiß Josefine , von Appen Wilken-Jon , Niehoff Barbara , Hildebrand Nicole , Graeve Martin , Neuhaus Stefan , Bracher Astrid , Nöthig Eva-Maria , Metfies Katja 
Published: October 2023

Abstract
In Fram Strait, we combined underway-sampling using the remote-controlled Automated Filtration System for Marine Microbes (AUTOFIM) with CTD-sampling for eDNA analyses, and with high-resolution optical measurements in an unprecedented approach to determine variability in plankton composition in response to physical forcing in a sub-mesoscale filament. We determined plankton composition and biomass near the surface with a horizontal resolution of ~ 2 km, and addressed vertical variability at five selected sites. Inside and near the filament, plankton composition was tightly linked to the hydrological dynamics related to the presence of sea ice. The comprehensive data set indicates that sea-ice melt related stratification near the surface inside the sub-mesoscale filament resulted in increased sequence abundances of sea ice-associated diatoms and zooplankton near the surface. In analogy to the physical data set, the underway eDNA data, complemented with highly sampled phytoplankton pigment data suggest a corridor of 7 km along the filament with enhanced photosynthetic biomass and sequence abundances of sea-ice associated plankton. Thus, based on our data we extrapolated an area of 350 km2 in Fram Strait with enhanced plankton abundances, possibly leading to enhanced POC export in an area that is around a magnitude larger than the visible streak of sea-ice.
Outpatient Mental Health Care During the First Three High Incidence Phases of the COVID-19 Pandemic in Germany - Results from the COVID Ψ Outpatient Survey
Authors: Fehr Mandy , Köhler Sabine , Roth-Sackenheim Christa , Geschke Katharina , Tüscher Oliver , Adorjan Kristina , Lieb Klaus , Hölzel Lars P. , Wiegand Hauke F. 
Published: October 2023

Abstract
Background
Internationally, the COVID-19 pandemic went along with significant shifts in utilization of mental healthcare inpatient and outpatient offerings. As only a few studies have examined the situation of the mental health outpatient systems in Europe so far, the COVID Ψ Outpatient Survey surveyed outpatient providers in Germany regarding changes in utilization; associated problems, challenges and contributing factors; telemedicine services; interactions with inpatient mental health and nursing home services; and experiences with post-COVID syndromes.
Methods
N = 105 outpatient mental health specialists of all regions of Germany took part in the online survey. It consisted of a combination of pre-formulated and free text responses.
Results
For the first high incidence phase (HIP) of the COVID-19 pandemic in spring 2020, 31% of the survey participants reported a decrease > 20% and 5% an increase > 20% of contacts. For the third HIP in spring 2021, 4% reported a decrease > 20% in the number of contacts, while 30% indicated an increase > 20%. Often suggested reasons for initial decreases were patients fears of infection and providers protection measures, and for later increases pandemic and lockdown-related anxieties and economic stressors, and capacity reductions of the inpatient system. The participants related the initial capacity reductions of both inpatient and outpatient system to multiple complications. Telemedicine offerings were introduced by many providers and already in summer 2021 a majority reported consultations for post-COVID syndromes.
Conclusions
The survey hints at changes in utilization, multiple problems but as well good-practice-solutions in the mental health outpatient system during the COVID-19 pandemic. For future crises a better surveillance is recommended.