bluuebunny/crossref_metadata_2025_split huggingface dataset:
Segmented Up‐Bending of the Arabian Continental Plate Revealed by Pn Attenuation Tomography
Authors: Yang Geng , Chen Ling , Zhao Lian‐Feng , Xie Xiao‐Bi , Yao Zhen‐Xing 
Published: December 2023

AbstractThe Zagros orogen in the Iranian Plateau serves as a natural laboratory for studying the tectonic evolution of the transition from oceanic subduction to continental collision. Various observations from both geology and geophysics show that deep oceanic slabs may have detached one after another from the Arabian continental margin, forming a complex plate front beneath the Zagros orogen. However, where slab detachment occurred and how slab detachment affects shallower continental underthrusting remain poorly understood. The mechanism behind the complex post‐collision magmatism remains elusive. While the uppermost mantle is often considered the heart of the mantle lid, its rheological variations can provide insights into the underlying thermal structure. Here, we construct a high‐resolution Pn‐wave attenuation model for the uppermost mantle beneath the Iranian Plateau and surrounding areas using a newly compiled data set and constrain the lithospheric structure by combining the Lg‐wave attenuation within the crust. Weak Pn‐wave attenuation outlines the boundary of the Arabian Plate near the Moho discontinuity, extending further in the direction of underthrusting in the northwestern and southeastern regions. This is likely due to the up‐bending and underplating of the Arabian lithosphere following the cessation of slab pull. The overlying crusts in northwestern and southeastern Zagros thickened under the compressive force from plate underplating. The correlations among the surface Miocene‐Quaternary volcanism, strong Lg attenuation in the crust and strong Pn attenuation in the uppermost mantle suggest that asthenospheric materials escaped from slab windows and further intruded into the upper mantle and crust to feed the post‐collision volcanoes.
Targeting serine/glycine metabolism improves radiotherapy response in non-small cell lung cancer
Authors: Sánchez-Castillo Anaís , Heylen Elien , Hounjet Judith , Savelkouls Kim G. , Lieuwes Natasja G. , Biemans Rianne , Dubois Ludwig J. , Reynders Kobe , Rouschop Kasper M. , Vaes Rianne D. W. , De Keersmaecker Kim , Lambrecht Maarten , Hendriks Lizza E. L. , De Ruysscher Dirk K. M. , Vooijs Marc , Kampen Kim R. 
Published: December 2023

Abstract
Background
Lung cancer is the most lethal cancer, and 85% of cases are classified as non-small cell lung cancer (NSCLC). Metabolic rewiring is a cancer hallmark that causes treatment resistance, and lacks insights into serine/glycine pathway adaptations upon radiotherapy.

Methods
We analyzed radiotherapy responses using mass-spectrometry-based metabolomics in NSCLC patient’s plasma and cell lines. Efficacy of serine/glycine conversion inhibitor sertraline with radiotherapy was investigated by proliferation, clonogenic and spheroid assays, and in vivo using a serine/glycine dependent NSCLC mouse model by assessment of tumor growth, metabolite and cytokine levels, and immune signatures.

Results
Serine/glycine pathway metabolites were significantly consumed in response to radiotherapy in NSCLC patients and cell models. Combining sertraline with radiotherapy impaired NSCLC proliferation, clonogenicity and stem cell self-renewal capacity. In vivo, NSCLC tumor growth was reduced solely in the sertraline plus radiotherapy combination treatment group. Tumor weights linked to systemic serine/glycine pathway metabolite levels, and were inhibited in the combination therapy group. Interestingly, combination therapy reshaped the tumor microenvironment via cytokines associated with natural killer cells, supported by eradication of immune checkpoint galectin-1 and elevated granzyme B levels.

Conclusion
Our findings highlight that targeting serine/glycine metabolism using sertraline restricts cancer cell recovery from radiotherapy and provides tumor control through immunomodulation in NSCLC.
Current harmonic suppression strategy for permanent magnet synchronous motor based on small phase angle resonant controller
Authors: Xie Fang , Xu Jinhu , Shen Mengyuan , Zheng Ziang 
Published: December 2023

AbstractIn this study, a small phase angle resonant controller (SPARC) is designed to suppress the current harmonics in a permanent magnet synchronous motor (PMSM). First, the analytical model of the PMSM is established. Second, a SPARC is designed to improve the problem of the overly large phase angle of the resonant controller at the resonant frequency. Third, the frequency error caused by the SPARC discretisation is compensated online. Finally, an experimental platform is built for the PMSM harmonic suppression, and the effectiveness and feasibility of the proposed method are verified through a comparison with the method of motor control using quasi‐resonant controller.
A novel refined maintenance strategy for full life cycle of high‐speed automatic train protection system
Authors: Kang Renwei , Pang Yanzhi , Cheng Jianfeng , Xu Peng , Chen Jianqiu , Zhang Kaiyuan 
Published: December 2023

AbstractAutomatic train protection (ATP) system is essential for ensuring the safe operation of high‐speed trains. However, the existing extensive and fixed maintenance mode of the ATP system results in a waste of resources. To achieve a state of operation and maintenance that ensures both protection capability and economic efficiency, a lean method in a dynamic maintenance mode for the full life cycle of the ATP system is proposed. Firstly, reliability tests are carried out based on historical failure data. The parameter values of the possible life distribution are estimated by maximum likelihood method, and the optimal life distribution of different devices is obtained through the Kolmogorov–Smirnov hypothesis test. Secondly, a dynamic failure rate function is introduced to describe the impact of maintenance on device performance. A refined maintenance model is then established within the life cycle, and the dynamically changing preventive maintenance intervals and frequencies are obtained using a genetic algorithm. Finally, to mitigate the impact of the intermittent operation of ATP system on maintenance, the multidimensional relationships among the maintenance strategy, service time and operation mileage are revealed. The effectiveness of the proposed method is verified through an example test on a type of driver machine interface device.
Stochastic operation model for readiness assessment of small wind turbines based on Markov theory
Authors: Zalewska‐Lesiak Justyna , Małachowski Jerzy , Szkutnik‐Rogoż Joanna 
Published: December 2023

AbstractWind energy is now one of the most important alternative sources of renewable energy. The development of wind power generation is a prerequisite to meet environmental and sustainable development requirements while achieving energy security goals. The condition for the effectiveness of the proper operation of a wind power plant is its ability to perform the intended functions, which can be expressed by the coefficient of technical readiness. This article presents an original analysis of the readiness of small wind turbines. As part of the research, an original stochastic operation model was developed based on the application of the Markov process theory. Based on the collected data, a 3‐state phase space of the studied process was identified. Various analyses were carried out to calculate the operating coefficients of wind power plants. The ergodic (boundary) probabilities were calculated using three methods. The conditional probabilities were then determined based on the initial distribution. The resulting readiness factors, not exceeding 30%, indicate the low operational efficiency of the small wind turbines in question. Furthermore, an analysis of the sensitivity of the performance factors was carried out for the analysed objects.
Peak Nasal Inspiratory Flow (PNIF) for Nasal Breathing Evaluation
Authors: Xavier Rui 
Published: December 2023

AbstractMeasuring nasal airflow and nasal breathing has been a major goal of rhinology. Many objective methods for measuring nasal airflow or nasal airway resistance or dimensions provide valuable data but are time-consuming and require expensive equipment and trained technicians, thus making these methods less practical for clinical practice. Peak nasal inspiratory flow (PNIF) measurement is fast, unexpensive, noninvasive, and able to provide an objective evaluation of nasal airflow in real-time. Unilateral PNIF measurements allow separated evaluation of each side of the nasal airway and may prove particularly useful when clinical assessment detects significant asymmetry between both nasal cavities.PNIF measurements are most useful for assessing changes in nasal airflow achieved by any form of therapy, including surgical treatment of the nasal airway. These measurements generally correlate with other objective methods for nasal airway evaluation, but not unequivocally with patient-reported evaluation of nasal breathing. Nevertheless, as low PNIF values prevent the sensation of a suitable nasal breathing, PNIF measurement may also prove useful to optimize the decision of how to best address patients with complaints of nasal airway obstruction.
Suspected Myocarditis after mRNA COVID-19 Vaccination among South Korean Adolescents
Authors: Kim Mi Jin , Kim Jin Hee , Jun Hyun Ok , Kim Kyung Min , Jeung Min Sub , Park Jun Sung 
Published: December 2023

Abstract
Objective Since vaccination for coronavirus disease 2019 (COVID-19) has been initiated, rare cases of COVID-19 mRNA vaccination-associated myocarditis (VAM) have been reported worldwide. This study aimed to report the short-term outcomes and the clinical presentation of VAM in South Korean adolescents.
Methods In this prospective multicenter study across five tertiary hospitals in South Korea, patients aged 12 to 17 years with symptoms of VAM were included from October 18, 2021, to April 30, 2022. We performed laboratory tests, electrocardiography, chest radiography, echocardiography, and cardiac magnetic resonance imaging studies on these patients.
Results A total of 14 patients were diagnosed with VAM during the study period. The median age of the patients was 15.2 years (interquartile range [IQR], 14.6–15.9) and 11 patients (78.6%) were male. All patients had received a messenger RNA Pfizer-BioNTech COVID-19 vaccine. The median latent period from vaccination to symptom onset was 1 (range, 0–8; IQR, 0.8–3.5) day. Chest pain was the most common symptom (11/14, 78.6%), and the median duration of symptoms was 1 week. Except for one patient (7.1%) who was admitted to intensive care unit, most patients (13/14, 93.8%) had a minor and short clinical course without an intensive treatment including an immune modulator.
Conclusion VAM in South Korean adolescents had self-limiting clinical courses as reported by previous studies. Despite the small number of cases, our findings, consistent with previous studies, revealed that East Asian adolescents might have a similar or even milder clinical course than adolescents of other ethnicities.
Comparison of Clinical, Laboratory Parameters, and Outcome of COVID-19-Positive and Negative Neonates Delivered from COVID-19-Positive Mothers
Authors: Singh Preeti , Kumar Ankur , Mehta Anita , Chauhan Mudit 
Published: December 2023

Abstract
Objective Severe acute respiratory syndrome coronavirus 2 is a highly contagious respiratory viral infection that affects all individuals, although neonates are considered to be the most susceptible populations; therefore, this study was conducted to evaluate the clinical outcome and association between coronavirus disease 2019 (COVID-19)-positive mothers and newborns.
Methods This cross-sectional study was conducted at a dedicated COVID-19 tertiary care hospital in India over a period of 1 year. The pregnant mothers infected with COVID-19 virus were enrolled with their newborn baby up to the age of 28 days. COVID-19 test was done by using a rapid antigen kit and further confirmed by reverse-transcription polymerase chain reaction.
Results Prevalence of COVID-19-positive newborns born of COVID-19-positive mothers is reported at 8.4%. Female:male ratio was found to be 1:1.2. Raised D-dimer (88.9%) and C-reactive protein (88.9%) were the most common findings in COVID-19-positive newborns followed by leucopenia (33.3%). Among the COVID-19 newborns, Apgar score less than or equal to 7 and respiratory distress were found in 55.6 and 33.3%, respectively. Out of 9 COVID-19-positive newborns, two (22.2%) were expired, and out of 98 COVID-19-negative newborns, 4(4.1%) were expired.
Conclusion This study revealed that severity of maternal symptoms is related to mortality of newborns. About 22.2% COVID-19-positive newborns expired, whereas 4.1% of COVID-19-negative newborns expired so risk of mortality increased among COVID-19-positive neonates as compared with negative ones. However, this study was conducted on a small sample size and further research with larger populations is needed to validate these findings.
Reshaping neuroimmunology: diagnosis and treatment in the era of precision medicine
Authors: dos Passos Giordani Rodrigues , Adoni Tarso , Mendes Maria Fernanda , Sato Douglas Kazutoshi 
Published: December 2023

AbstractPrecision medicine has revolutionized the field of neuroimmunology, with innovative approaches that characterize diseases based on their biology, deeper understanding of the factors leading to heterogeneity within the same disease, development of targeted therapies, and strategies to tailor therapies to each patient. This review explores the impact of precision medicine on various neuroimmunological conditions, including multiple sclerosis (MS), neuromyelitis optica spectrum disorder (NMOSD), myelin oligodendrocyte glycoprotein antibody-associated disease (MOGAD), optic neuritis, autoimmune encephalitis, and immune-mediated neuropathies. We discuss advances in disease subtyping, recognition of novel entities, promising biomarkers, and the development of more selective monoclonal antibodies and cutting-edge synthetic cell-based immunotherapies in neuroimmunological disorders. In addition, we analyze the challenges related to affordability and equity in the implementation of these emerging technologies, especially in situations with limited resources.
Gonadotropins in the Management of Couple Infertility: Toward the Rational Use of an Empirical Therapy
Authors: Romeo Marilina , Donno Valeria , Spaggiari Giorgia , Granata Antonio R.M. , Simoni Manuela , La Marca Antonio , Santi Daniele 
Published: December 2023

AbstractAlthough epidemiology shows that both men and woman can experience infertility, the female partner usually experiences most of the diagnostic and therapeutic burden. Thus, management of couple infertility is a unique example of gender inequality. The use of exogenous gonadotropins in assisted reproductive technology (ART) to induce multifollicular growth is well consolidated in women, but the same is not done with the same level of confidence and purpose in infertile men. Indeed, the treatment of idiopathic male infertility is based on an empirical approach that involves administration of the follicle-stimulating hormone (FSH) in dosages within the replacement therapy range. This treatment has so far been attempted when the endogenous FSH serum levels are within the reference ranges. According to the most recent evidence, a “substitutive” FSH administration may not be effective enough, while a stimulatory approach could boost spermatogenesis over its basal levels without adverse extragonadal effects. This article aims to describe the rationale behind the empirical application of gonadotropins in couple infertility, highlighting the need for a change in the therapeutic approach, especially for the male partner.
Deaf children, home language environments, and reciprocal–contingent family interactions
Authors: Ocuto Oscar L 
Published: December 2023

Abstract
Engaged communication between mother and a child in their early developmental stages is one of the predictors of children’s development of higher-order thinking skills. For deaf children, this engaged communication between mother and child hinges on the home language environment (HLE) being fully accessible to the child. This research uses agogical phenomenology in exploring the lived experiences of participants’ HLE where sign language is used, with particular focus on the opportunities for extended discourse. Data were collected via semistructured interviews with the deaf children and their parents and observations in the HLEs of five signing families with at least one deaf child in the southwestern United States. The aim of this study was to document and provide insights into how language use in deaf children’s HLE can impact their knowledge development; these insights uncovered the essence of reciprocal and contingent family interactions as a central aspect of the deaf child’s HLE. It is hoped that the qualitative phenomenological findings will frame subsequent quantitative investigations of the variability in language access to home language components.
Divergent gametic thermal performance and floral warming across an elevation gradient
Authors: Heiling Jacob M , Koski Matthew H 
Published: December 2023

Abstract
Thermal environments vary widely across species ranges, establishing the potential for local adaptation of thermal performance optima and tolerance. In the absence of local adaptation, selection should favor mechanisms to meet thermal optima. Floral temperature is a major determinant of reproductive success in angiosperms, yet whether gametic thermal performance shows signatures of local adaptation across temperature gradients, and how variation in gametic thermal performance influences floral evolution, is unknown. We characterized flowering season temperatures for the forb, Argentina anserina, at extremes of a 1000 m elevation gradient and generated thermal performance curves for pollen and ovule performance in populations at each extreme. Thermal optima fell between mean and maximum intrafloral temperatures. However, cooler high-elevation populations had ~4 °C greater pollen thermal optima than warmer low-elevation populations, while tolerance breadths did not differ. We then tested whether plants at elevational extremes differentially warmed the floral microenvironment. High-elevation flowers warmed significantly more than low, bringing intrafloral temperatures nearer the pollen optima. A manipulative experiment demonstrated that stronger warming in high elevation was conferred by floral tissues. Elevational divergence in floral warming may be driven, in part, by selection on flowers to meet different thermal demands of the gametophytes.
Ectopic Expression of C-Type Lectin Mincle Renders Mice Susceptible to Staphylococcal Pneumonia
Authors: Hollwedel Femke D , Maus Regina , Stolper Jennifer , Iwai Satoru , Kasai Hayato , Holtfreter Silva , Pich Andreas , Neubert Lavinia , Welte Tobias , Yamasaki Sho , Maus Ulrich A 
Published: December 2023

Abstract
Staphylococcus aureus is a prevalent pathogen in pneumonia and harbors glycolipids, which may serve as molecular patterns in Mincle (macrophage-inducible C-type lectin)–dependent pathogen recognition. We examined the role of Mincle in lung defense against S aureus in wild-type (WT), Mincle knockout (KO), and Mincle transgenic (tg) mice. Two glycolipids, glucosyl-diacylglycerol (Glc-DAG) and diglucosyl-diacylglycerol (Glc2-DAG), were purified, of which only Glc-DAG triggered Mincle reporter cell activation and professional phagocyte responses. Proteomic profiling revealed that Glc2-DAG blocked Glc-DAG–induced cytokine responses, thereby acting as inhibitor of Glc-DAG/Mincle signaling. WT mice responded to S aureus with a similar lung pathology as Mincle KO mice, most likely due to Glc2-DAG–dependent inhibition of Glc-DAG/Mincle signaling. In contrast, ectopic Mincle expression caused severe lung pathology in S aureus–infected mice, characterized by bacterial outgrowth and fatal pneumonia. Collectively, Glc2-DAG inhibits Glc-DAG/Mincle–dependent responses in WT mice, whereas sustained Mincle expression overrides Glc2-DAG–mediated inhibitory effects, conferring increased host susceptibility to S aureus.
Clinical, microbiological and genomic characterization of Gram-negative bacteria with dual carbapenemases as identified by rapid molecular testing
Authors: Mushtaq Ammara , Alburquerque Bremy , Chung Marilyn , Fabre Shelcie , Sullivan Mitchell J , Nowak Michael , Sordillo Emilia M , Polanco Jose , van Bakel Harm , Gitman Melissa R 
Published: December 2023

Abstract

Objective
Dual carbapenemase-producing organisms (DCPOs) are an emerging threat that expands the spectrum of antimicrobial resistance. There is limited literature on the clinical and genetic epidemiology of DCPOs.

Methods
DCPO isolates were identified by Xpert® Carba-R PCR testing of routine diagnostic cultures performed from 2018 to 2021 at a New York City health system. WGS was performed by Illumina and/or PacBio. Medical records of patients were reviewed for clinical and epidemiological data.

Results
Twenty-six DCPO isolates were obtained from 13 patients. Klebsiella pneumoniae (n = 22) was most frequent, followed by Pseudomonas aeruginosa (n = 2), Escherichia coli (n = 1) and Enterobacter cloacae (n = 1). The most common DCPO combination was blaNDM/blaOXA-48-like (n = 16). Notably, 1.05% (24/2290) of carbapenem-resistant Enterobacterales isolates were identified as DCPOs. The susceptibility profiles matched the identified resistance genes, except for a K. pneumoniae (blaKPC/blaOXA-48-like) isolate that was phenotypically susceptible to meropenem. Eleven patients were hospitalized within the year prior to admission, and received antibiotic(s) 1 month prior. Seven patients were originally from outside the USA. Hypertension, kidney disease and diabetes were frequent comorbidities. Death in two cases was attributed to DCPO infection. WGS of eight isolates showed that carbapenemases were located on distinct plasmids, except for one K. pneumoniae isolate where NDM and KPC carbapenemases were located on a single IncC-type plasmid backbone.

Conclusions
Here we characterized a series of DCPOs from New York City. Foreign travel, prior hospitalization, antibiotic usage and comorbidities were common among DCPO cases. All carbapenemases were encoded on plasmids, which may facilitate horizontal transfer.