bluuebunny/crossref_metadata_2025_split huggingface dataset:
Bedaquiline in the postoperative period of complex therapy of tuberculosis
Authors: Kondakova M. N. , Kovaleva R. G. , Tyarasova K. G. , Elkin A. V. , Khorkova S. M. 
Published: November 2023

Introduction. The experience of domestic phthisiatry, which has been using bedaquiline for more than 10 years, testifies to the efficacy and safety of the drug for the treatment of drug-resistant forms of tuberculosis. At the present stage, the evaluation of the effect and safety of bedaquiline in the postoperative stage of chemotherapy, including patients with HIV/tuberculosis co-infection, becomes the most relevant.Aim. To evaluate the results of bedaquiline application in the postoperative stage of complex tuberculosis therapy.Materials and methods. Results of a retrospective study of medical records of 57 patients. The inclusion criterion was the surgery performed for tuberculosis and the presence of bedaquiline in the postoperative chemotherapy regimen. Frequency of tuberculosis progression 1 month after surgery was evaluated as an efficacy criterion. The frequency of QTc interval prolongation with clinical manifestations, frequency and nature of hepatotoxic reactions were evaluated as the drug safety criterion.Results. In the absolute majority of patients – 54 (94.7%) postoperative period, during which bedaquiline was used, proceeded without complications. Cases of tuberculosis progression were observed only in patients with severe concomitant diseases. Undesirable side effects on bedaquiline were observed in 9 (15.8%) patients, the absolute majority of patients resumed taking the drug in full after drug correction. The average duration of bedaquiline prescription was 282 ± 5 doses.Conclusions. The use of bedaquiline in the postoperative period increases the effectiveness of complex therapy and prevents progression of tuberculosis and according to our data should be regarded as safe. Administration of bedaquiline in patients with HIV/tuberculosis co-infection also contributes to the positive result of the therapy. Repeated courses of bedaquiline after surgical intervention, including in patients with HIV/tuberculosis co-infection, prevent progression of tuberculosis in the postoperative period. The tolerability of the bedaquiline-containing regimen in this category of patients, including long courses of more than 24 weeks, was assessed as quite satisfactory.
Efficacy of triple targeted therapy against chronic rhinosinusitis in children with cystic fibrosis (case series)
Authors: Polyakov D. P. , Kondratyeva E. I. , Voronkova A. Y. , Ramazanova P. I. 
Published: November 2023

Introduction. Chronic rhinosinusitis (CRS) with underlying cystic fibrosis (CF) is one of the most challenging inflammatory diseases of the paranasal sinuses (PNS). The treatment of CF in general and CF-associated CRS in particular keeps developing exponentially: special drug delivery systems have been invented, drugs purpose-developed for the treatment of patients with CF (dornase alfa) are used, and radicality of surgical intervention is increasing. In recent years, CF innovative targeted therapy has been introduced. It aims to improve the course of the bronchopulmonary infectious and inflammatory process, nutritional status and pancreatic function, but its efficacy in relation to the PNS condition is still insufficiently studied.Aim. To evaluate the efficacy of ivacaftor/elexacaftor/tezacaftor therapy for CF sinonasal manifestations in children and to determine possible parallels of the CRS course vs other characteristics of the CF course.Materials and methods. A total of 15 children with CF receiving triple targeted therapy were included in the first series of observations. Computed tomography (CT) scans were assessed using the Lund-Mackay scores (LMS) before and 7.6 ± 3.0 months after starting the therapy. In addition, the changes in sweat chloride levels and pulmonary function test results were taken into account. The control group included 11 patients with comparable initial radiographic data who did not receive such therapy.Results and discussion. The treatment group showed a significant improvement in the PNS condition in the form of a decrease in the LMS scores from 15.6 ± 4.5 to 2.1 ± 3.0 (p = 0.001) with inhomogeneous changes vs different PNS groups. A certain parallelism between changes in the CT view and the level of sweat chlorides and pulmonary function test results was reported. In the control group, a nonsignificant deterioration in the course of CRS was observed (from 12.3 ± 6.3 to 14.6 ± 4.9 scores according to LMS; p = 0.108).Conclusions. The study demonstrated high efficacy of CF triple targeted therapy with ivacaftor/elexacaftor/tezacaftor in relation to the severe CRS with a rapid onset of effect in the form of PNS pneumatization restoration according to CT findings.
Possible perspectives for using phytoadaptogens in post-COVID period
Authors: Sankova M. V. , Mesitskaya D. F. , Andreev D. A. , Sankov A. V. 
Published: November 2023

Currently the new coronavirus infection caused by SARS-CoV-2 continues to be a serious public health problem. The fight against this virus includes a continuous search not only for the optimal treatment of the disease itself, but also for the full rehabilitation of patients in the postcovid period. Given the clinical variability and the need for one-stage correcting functions of many systems and organs after this disease, it seems appropriate to use in the recovery of these patients plant adaptogens, which have multiple effects on the body. Our review demonstrates the phytoadaptogen uniqueness in their mild multidirectional impact on neuroendocrine-immune regulation, which leads to the correcton of physiological functions disturbed during the disease. Plantl adaptogens were shown to help reduce pathological changes in the lungs, have antihypoxic and antioxidant effects, exhibit psychotropic and neuroprotective properties, influence on carbohydrate metabolism and cardiovascular system activity, support immune homeostasis and have a general adaptogenic effect. In addition, these biologics enhance the effectiveness of the entire complex therapy and allow neutralizing the side effects of the jointly taken synthetic drugs. To achieve the optimal effect of phytoadaptogens in post-COVID-19 patients it is preferable to use adaptogenic plant combinations, taking into account the mutually reinforcing pharmacological plant properties and leading pathognomonic syndromes. The phytoadaptogen use in the post-COVID-19 patient treatment will contribute to their psychoemotional stabilization, immunoresistance increase, pathological change regression in organs and tissues, mental and physical performance improvement, which will eventually improve the life quality of recovered from COVID-19 patients and preserve public health.
Priority choice of topical antibacterial drugs in the commonly accepted paradigm of acute rhinosinusitis treatment
Authors: Krivopalov A. A. , Ryazantsev S. V. , Turieva V. V. , Krasheninnikova L. S. 
Published: November 2023

Introduction. In the complex therapy of acute rhinosinusitis, topical drugs with different mechanisms of action and influence on the main links in the pathogenesis of acute infectious lesions of the mucous membrane of the paranasal sinuses are widely used. Local drugs with antibacterial, as well as mucolytic and vasoconstrictor effects do not inhibit mucociliary clearance, have a convenient release form and ensure dosing accuracy with each use.Aim. Evaluation of the clinical effectiveness of the use in complex therapy of a topical antibiotic of the aminoglycoside group in combination with a drug having vasoconstrictive and mucolytic effects of domestic production in the treatment of acute bacterial rhinosinusitis.Materials and methods. The study involved 30 patients with a verified diagnosis of acute bacterial rhinosinusitis of moderate severity aged 18 to 68 years, who were divided into two groups. Patients of the first group (n = 15), in addition to complex treatment (antibacterial, antihistamine and unloading therapy, anti-inflammatory and puncture treatment), used a drug with a bactericidal effect from the group of aminoglycosides (Tramicent). Patients of the second group (n = 15) supplemented the same treatment with a drug with mucolytic and vasoconstrictive action (Rhinostein®). The effectiveness of therapy was evaluated based on the results of three visits to the doctor within two weeks.Results. The positive dynamics of the subjective and objective status of patients in both study groups was noted. By the 3rd visit (10–14 days), the severity of clinical manifestations in patients who used two drugs Tramicent and Rhinostein® as additional therapy was 2 times lower than at the first visit compared with the group of patients who used only Tramicent as additional therapy. The absence of complaints after treatment in the 2nd group was noted by 15% of the examined, in the 1st – 10%.Conclusions. Topical drug from the group of aminoglycosides containing the active substance framycetin sulfate (Tramicent) in the form of a spray is a safe and effective remedy in the complex therapy of bacterial rhinosinusitis, and its use in combination with the drug mucolytic and vasoconstrictive action (Rhinostein®) significantly reduces the duration of treatment and improves the quality of life of patients.
Effects of micro-bubble aeration on the pollutant removal and energy-efficient process in a floc–granule sludge coexistence system
Authors: Liu Minghui , Wang Ju , Peng Zhaoxu 
Published: November 2023

Abstract

To investigate energy-saving approaches in wastewater treatment plants and decrease aeration energy consumption, this study successfully established a floc–granule coexistence system in a sequencing batch airlift reactor (SBAR) employing micro-bubble aeration. The analysis focused on granule formation and pollutant removal under various aeration intensities, and compared its performance with a traditional floc-based coarse-bubble aeration system. The results showed that granulation efficiency was positively associated with aeration intensity, which enhanced the secretion of extracellular polymeric substances (EPSs) and facilitated granule formation. The SBAR with the micro-aeration intensity of 30 mL·min−1 showed the best granulation performance (granulation efficiency 52.6%). In contrast to the floc-based system, the floc–granule coexistence system showed better treatment performance, and the best removal efficiencies of NH4+-N, TN, and TP were 100.0, 77.0, and 89.5%, respectively. The floc–granule coexistence system also enriched higher abundance of nutrients removal microbial species, such as Nitrosomonas (0.05–0.14%), Nitrospira (0.14–2.32%), Azoarcus (2.95–12.17%), Thauera (0.43–1.95%), and Paracoccus (0.76–2.89%). The energy-saving potential was evaluated, which indicated it is feasible for the micro-aeration floc–granule coexistence system to decrease the aeration consumption by 14.4% as well as improve the effluent.
Assessment of sustainable drainage strategies in urban water systems using urban water metabolism and multi-criteria decision analyses
Authors: Garcia Maria Vitória da Silva , Moruzzi Rodrigo Braga , Behzadian Kourosh 
Published: November 2023

Abstract

The simulation of urban water metabolism (UWM) allows for the tracking of all water, energy, and material flows within urban water systems (UWSs) and the quantification of their performance, including emissions into the air, water, and soil. This study evaluates seven drainage strategies (DSs) within conventional and sustainable urban drainage systems (SUDSs) using UWM and multicriteria decision analysis (MCDA). The DSs were designed to assess their corresponding UWM performances, employing key performance indicators (KPIs) related to sewer system balance, energy consumption, greenhouse gas (GHG) emissions, acidification, eutrophication, contamination, and sludge production. The outcomes were ranked using the compromise programming MCDA model. The top three strategies were permeable pavements, green spaces, and infiltration trenches and sand filters. The approach used for the evaluation of DS can provide valuable insights for decision-makers, support the promotion of sustainable integrated UWS management and adaptation, and accommodate design variations in urban drainage. Sensitivity analysis on uncertain parameters and KPI selection also contributed to robust and sustainable urban drainage solutions.
The Antidiabetic Mechanisms of Hesperidin: Hesperidin Nanocarriers as Promising Therapeutic Options for Diabetes
Authors: Kaviani Fatemeh , Baratpour Iraj , Ghasemi Sorayya 
Published: November 2023

:
A natural flavonoid with exceptional medicinal capabilities, hesperidin, has
shown encouraging results in the treatment of diabetes. Thoughts are still being held
on the particular processes through which hesperidin exerts its anti-diabetic effects.
This work clarifies the complex antidiabetic mechanisms of hesperidin by investigating
the molecular pathways involved in glucose homeostasis, insulin signaling, and
oxidative stress control. Additionally, the article explores the newly developing field of
nanocarrier-based systems as a prospective means of boosting the therapeutic
efficiency of hesperidin in the treatment of diabetes. This is because there are
difficulties connected with the efficient delivery of hesperidin. These cutting-edge
platforms show enormous potential for changing diabetes therapy by utilizing the
benefits of nanocarriers, such as enhanced solubility, stability, and targeted delivery. In
conclusion, our comprehensive review emphasizes the antidiabetic potential of
hesperidin and underscores the intriguing possibilities provided by hesperidin
nanocarriers in the search for more effective and individualized diabetes therapies.
Bandwidth-enhanced FSS-loaded Semi-circular Patch Antenna for C-band Applications
Authors: Akash Umapathi , Balachandar Sujithrajan , Surapuramath Kavya , Badanikai Manas , Dwarakanath Varun 
Published: November 2023

Aim:
This study aimed to develop and analyse a bandwidth-enhanced C band antenna
loaded with EBG and FSS Structures to improve the antenna performance.

Methods:
This paper illustrates the design of a semi-circular microstrip antenna with a modified circular
ring Frequency Selective Surface (FSS) and an Electromagnetic Band Gap (EBG) structure for
improved bandwidth and an omnidirectional pattern. The patch antenna is aimed at C-Band intersatellite
communication links in a constellation.

Results and Discussion:
In literature, the application of EBG and FSS together is seldom used. The
semicircular patch is aimed at retaining the omnidirectional antenna pattern at higher frequencies, as
well as bandwidth, which is achieved through FSS and EBG structures. The modeling and simulation of
the antenna have been carried out with 3D EM solvers. The simulated patch antenna operates in a wideband
ranging from 4.1 GHz to 7.1 GHz with a gain of 1.9 dB at 5.33 GHz and 1.4 dB at 4.5 GHz.

Conclusion:
The proposed antenna design is vertically polarized. The simulation results are validated
with measurement results.
A Machine Learning–Based Preclinical Osteoporosis Screening Tool (POST): Model Development and Validation Study
Authors: Yang Qingling , Cheng Huilin , Qin Jing , Loke Alice Yuen , Ngai Fei Wan , Chong Ka Chun , Zhang Dexing , Gao Yang , Wang Harry Haoxiang , Liu Zhaomin , Hao Chun , Xie Yao Jie 
Published: November 2023

Abstract

Background
Identifying persons with a high risk of developing osteoporosis and preventing the occurrence of the first fracture is a health care priority. Most existing osteoporosis screening tools have high sensitivity but relatively low specificity.

Objective
We aimed to develop an easily accessible and high-performance preclinical risk screening tool for osteoporosis using a machine learning–based method among the Hong Kong Chinese population.

Methods
Participants aged 45 years or older were enrolled from 6 clinics in the 3 major districts of Hong Kong. The potential risk factors for osteoporosis were collected through a validated, self-administered questionnaire and then filtered using a machine learning–based method. Bone mineral density was measured with dual-energy x-ray absorptiometry at the clinics; osteoporosis was defined as a t score of −2.5 or lower. We constructed machine learning models, including gradient boosting machines, support vector machines, and naive Bayes, as well as the commonly used logistic regression models, for the prediction of osteoporosis. The best-performing model was chosen as the final tool, named the Preclinical Osteoporosis Screening Tool (POST). Model performance was evaluated by the area under the receiver operating characteristic curve (AUC) and other metrics.

Results
Among the 800 participants enrolled in this study, the prevalence of osteoporosis was 10.6% (n=85). The machine learning–based Boruta algorithm identified 15 significantly important predictors from the 113 potential risk factors. Seven variables were further selected based on their accessibility and convenience for daily self-assessment and health care practice, including age, gender, education level, decreased body height, BMI, number of teeth lost, and the intake of vitamin D supplements, to construct the POST. The AUC of the POST was 0.86 and the sensitivity, specificity, and accuracy were all 0.83. The positive predictive value, negative predictive value, and F1-score were 0.41, 0.98, and 0.56, respectively.

Conclusions
The machine learning–based POST was conveniently accessible and exhibited accurate discriminative capabilities for the prediction of osteoporosis; it might be useful to guide population-based preclinical screening of osteoporosis and clinical decision-making.
Correlation Between Remote Symptom Reporting by Caregivers and Adverse Clinical Outcomes: Mixed Methods Study
Authors: Oakley-Girvan Ingrid , Yunis Reem , Fonda Stephanie J , Longmire Michelle , Veuthey Tess L , Shieh Jennifer , Aghaee Sara , Kubo Ai , Davis Sharon W , Liu Raymond , Neeman Elad 
Published: November 2023

Background
Timely collection of patient-reported outcomes (PROs) decreases emergency department visits and hospitalizations and increases survival. However, little is known about the outcome predictivity of unpaid informal caregivers’ reporting using similar clinical outcome assessments.

Objective
The aim of this study is to assess whether caregivers and adults with cancer adhered to a planned schedule for electronically collecting patient-reported outcomes (PROs) and if PROs were associated with future clinical events.

Methods
We developed 2 iPhone apps to collect PROs, one for patients with cancer and another for caregivers. We enrolled 52 patient-caregiver dyads from Kaiser Permanente Northern California in a nonrandomized study. Participants used the apps independently for 4 weeks. Specific clinical events were obtained from the patients’ electronic health records up to 6 months following the study. We used logistic and quasi-Poisson regression analyses to test associations between PROs and clinical events.

Results
Participants completed 97% (251/260) of the planned Patient-Reported Outcomes Common Terminology Criteria for Adverse Events (PRO-CTCAE) surveys and 98% (254/260) of the Patient-Reported Outcomes Measurement Information System (PROMIS) surveys. PRO-CTCAE surveys completed by caregivers were associated with patients’ hospitalizations or emergency department visits, grade 3-4 treatment-related adverse events, dose reductions (P<.05), and hospice referrals (P=.03). PROMIS surveys completed by caregivers were associated with hospice referrals (P=.02). PRO-CTCAE surveys completed by patients were not associated with any clinical events, but their baseline PROMIS surveys were associated with mortality (P=.03), while their antecedent or final PROMIS surveys were associated with all clinical events examined except for total days of treatment breaks.

Conclusions
In this study, caregivers and patients completed PROs using smartphone apps as requested. The association of caregiver PRO-CTCAE surveys with patient clinical events suggests that this is a feasible approach to reducing patient burden in clinical trial data collection and may help provide early information about increasing symptom severity.
Enfermedad asociada a anticuerpos contra la glicoproteína de mielina de oligodendrocitos
Authors: Cárdenas Robledo Simón , Arenas-Vargas Laura Estefanía , Guerrero-Gómez Diego Armando , Carvajal-Junco René , Guío-Sánchez Claudia 
Published: November 2023

Introducción: la enfermedad asociada a anticuerpos contra la glicoproteína de mielina del oligodendrocito (MOGAD, por sus siglas en inglés) es una entidad clínica recientemente identificada. La frecuencia de presentación del MOGAD es desconocida, pero se considera baja con respecto a otras enfermedades inflamatorias desmielinizantes.
Materiales y métodos: revisión narrativa de la literatura.
Resultados: las manifestaciones clínicas de esta condición son heterogéneas e incluyen neuritis óptica, mielitis, desmielinización multifocal del sistema nervioso central y encefalitis cortical. Se han descrito algunos hallazgos radiológicos que aumentan la sospecha diagnóstica, como el realce perineural del nervio óptico, el signo de la H en el cordón espinal y la resolución de lesiones T2 con el tiempo. El diagnóstico se basa en la detección de inmunoglobulinas G específicas contra MOG, en el contexto clínico adecuado. El tratamiento consiste en manejo de los ataques agudos con dosis altas de corticoides y en algunos casos se deberá considerar la inmunosupresión crónica (pacientes con recurrencia o con discapacidad severa residual tras el primer evento).
Conclusiones: en esta revisión narrativa se resumen los aspectos clave con respecto a la fisiopatología, las manifestaciones, el diagnóstico y el tratamiento de la MOGAD.
The Effect of Service Quality on Customer Loyalty Through Perceived Value and Customer Satisfaction of Jakarta Mobile Banking Application
Authors: Sriwidadi Teguh , Prabowo Hartiwi 
Published: November 2023

Objectives: This study aims to examine the form of service quality which has profound effects on the way customers interact with firms to create positive service outcomes i.e., service quality, perceived value, customer satisfaction, and customer loyalty. Therefore, the main objective of this study is to examine the service quality’s impact on the user's perceived value, satisfaction, and loyalty in mobile banking.Methodology: This study uses a quantitative research method. The data has been collected from 498 service users through the online survey. Finding: Structural Equation Modelling is applied by using the PLS-SEM program to test the model. The study concluded that mobile banking service quality positively and significantly affects customer perceived value, customer satisfaction, and customer loyalty. Customer perceived value positively and significantly affects customer satisfaction, significantly but negatively affects customer loyalty, and customer satisfaction positively and significantly affects customer loyalty. Conclusion: This research has differences and similarities with the results of previous studies. This difference is caused by several things such as regional characteristics and participating respondents. The characteristics and behavior of consumers are unique so there may be differences in the results of the research conducted. The research results obtained from the hypothesis prove that the greater the influence of service quality, the greater the perceived value of the mobile banking application, and better customer service quality decreases customer loyalty, better customer service will further increase customer satisfaction. Better perceived value will further increase customer satisfaction, and better customer satisfaction increases customer loyalty.