bluuebunny/crossref_metadata_2025_split huggingface dataset:
Suicidal Thoughts and Trajectories of Psychopathological and Behavioral Symptoms in Adolescence
Authors: Uno Akito , Nagaoka Daiki , Usami Satoshi , Yamaguchi Satoshi , Minami Rin , Tanaka Riki , Sawai Yutaka , Okuma Ayako , Yamasaki Syudo , Miyashita Mitsuhiro , Nishida Atsushi , Kasai Kiyoto , Ando Shuntaro 
Published: January 2024

ImportanceThe suicidal risk of psychopathology in adolescence is suggested to differ based on its longitudinal trajectory, but the comorbidity of these symptom trajectories has not been well examined. This study comprehensively clustered trajectories of multiple psychopathological and behavioral symptoms and examined their associations with suicidal thoughts in adolescence.ObjectiveTo determine which categories and trajectories of psychopathological and behavioral symptoms are associated with suicidal thoughts in adolescence, accounting for comorbid symptoms.Design, Setting, and ParticipantsThis population-based cohort study in Japan used data from the Tokyo Teen Cohort (TTC) study, which was established in 2012 and is currently ongoing. Data from 3 waves of surveys conducted at ages 10, 12, and 16 years from October 2012 to September 2021 were used. Of the adolescents in the cohort, participants with at least 2 evaluations of psychopathological and behavioral symptoms were included. Data were analyzed from December 2022 to March 2023.ExposureLatent class growth analysis was used to cluster the trajectory of each psychopathological and behavioral symptom.Main Outcomes and MeasuresThe associations between symptom trajectories and suicidal thoughts at age 16 were examined. Suicidal thoughts were assessed using a self-report questionnaire. Psychopathological and behavioral symptoms were assessed using the 8 subscale scores of the caregiver-report Child Behavior Checklist.ResultsThis study included 2780 adolescents (1306 female participants [47.0%]). Of the 1920 adolescents with data on suicidal thoughts, 158 (8.2%) had suicidal thoughts. The median (IQR) age was 10.2 (10.0-10.3) years at the first evaluation, 11.9 (11.8-12.1) years at the second evaluation, and 16.3 (16.1-16.5) years at the last evaluation. The clustering pattern of trajectories varied depending on symptom categories. After adjusting for each symptom trajectory and confounders, adolescents with persistent high withdrawn symptoms (odds ratio [OR], 1.88; 95% CI, 1.10-3.21) and those with increasing somatic symptoms (OR, 1.97; 95% CI, 1.16-3.34) had a significantly higher risk of suicidal thoughts than adolescents without these symptoms. There was no interaction between these symptom trajectories and the risk of suicidal thoughts.Conclusions and RelevanceThis cohort study found that persistent withdrawn symptoms and increasing somatic symptoms during early to midadolescence were associated with an increased risk of suicidal thoughts in midadolescence, even after accounting for comorbid symptoms and confounders. Attention should be paid to the suicidal risk associated with these symptoms, particularly when they persist or increase in the longitudinal follow-up.
NIR Emissive Functional Nanoparticles Promote Precise Pancreatic Cancer Therapy by Co‐Targeting Mutant p53 and Oncogenic KRAS
Authors: Qian Jieying , Yang Zhenyu , Zhang Wang , Ye YaYi , Song Yang , Ye Yingxuan , Zhou Yuping , Zheng Qingqi , Huang Xiaowan , Du Sitong , Zhang Hao , Gao Meng , Zhang Yunjiao 
Published: January 2024

AbstractPancreatic ductal adenocarcinoma (PDAC) presents a formidable global health challenge. Targeting genetic aberrations, particularly KRAS and TP53 mutations, remains a critical challenge in PDAC treatment. Herein, it is demonstrated for the first time that electron‐rich aromatic pyrrole derivatives can be transformed into red‐to‐near‐infrared emissive radical cations in an acidic buffer, efficiently targeting mitochondria and triggering mutant p53 (mutp53) degradation. Leveraging the positive charge characteristic of radical cations (P6•+), a bifunctional nanoparticle is successfully engineered by combining P6•+ with KRAS siRNA. P6@siKRAS simultaneously induces mutp53 degradation and the oncogenic KRAS downregulation, thereby abrogating gain‐of‐function effects by mutp53 and inhibiting downstream signaling pathways regulated by KRAS, leading to significant suppression of tumor growth, invasion, and drug resistance. Consequently, P6@siKRAS demonstrates remarkable therapeutic efficacy in both the p53‐KRAS‐double‐mutated pancreatic cancer model and the LSL‐KrasG12D/+; LSL‐Trp53R172H/+; Pdx‐1‐Cre (KPC) mice model. Moreover, the down‐regulation of mutp53 and KRAS by P6@siKRAS not only inhibits tumor growth but also substantially remodels the tumor microenvironment, recruiting and boosting the infiltration of anti‐tumor immune cells, thereby augmenting the anti‐tumor immune response. This study showcases the development of mutp53‐degrading functional gene carriers, offering a promising and innovative therapeutic strategy for tackling p53‐KRAS‐double‐mutated pancreatic cancer.
Metalloporphyrin Frameworks to Encapsulate Copper Oxides for Boosting Ethylene Production in Neutral Electrolyte
Authors: Ma Mutian , Xiong Likun , Dong Yuan , Bai Qianqian , Hua Wei , Zheng Zhangyi , Lyu Fenglei , Lian Yuebin , Wei Zhihe , Yuan Huihong , Jiao Zhenyang , Cheng Jian , Song Daqi , Wang Min , Xing Zhiyuan , Zhong Jun , Han Sheng , Deng Zhao , Peng Yang 
Published: January 2024

AbstractElectrochemical carbon dioxide reduction (eCO2R) in neutral electrolytes represents a viable solution for alleviating energy and carbon losses associated with carbonate formation, but limited by suboptimal C2+ selectivity and productivity owing to the higher C−C coupling kinetic barrier in such media. To address the issue, here Cu2O nanocubes are encapsulated within metalloporphyrin frameworks to create a benign microenvironment for C−C coupling, with the best catalyst of Cu2O@Cu−TCPP(Co) demonstrating a maximal C2H4 and C2+ FE of 54 ± 2% and 69 ± 4%, respectively, at 500 mA cm−2 in 1 M KCl. Comprehensive structural and spectrometric characterizations utilizing in situ attenuated total reflectance surface‐enhanced infrared absorption spectroscopy (ATR−SEIRAS), in situ X‐ray absorption spectroscopy (XAS), operando Raman, and high‐resolution transmission electron microscopy (HR−TEM) unveil that the high CO2 adsorption endowed by the metal‐organic framework (MOF) overlayer, high CO concentration yield by metalloporphyrins, high local pH rendered by spatial confinement, as well as the highly dispersed Cu crystallites exposing (200) facets synergistically contribute to the asymmetric C−C coupling of *CO and *COH intermediates in favor of C2+ production. Orchestrating the active moieties in a concerted fashion, this study offers a paradigm for the design of eCO2R catalysts in neutral electrolytes.
Versatile Antibacterial and Antioxidant Bacterial Cellulose@Nanoceria Biotextile: Application in Reusable Antimicrobial Face Masks
Authors: Tang Jie , Zhang Yuping , Liu Xingfei , Lin Yichao , Liang Lihua , Li Xiaofang , Casals Gregori , Zhou Xiangyu , Casals Eudald , Zeng Muling 
Published: January 2024

AbstractDespite considerable interest in medical and pharmaceutical fields, there remains a notable absence of functional textiles that concurrently exhibit antibacterial and antioxidant properties. Herein, a new composite fabric constructed using nanostructured bacterial cellulose (BC) covalently‐linked with cerium oxide nanoparticles (BC@CeO2NPs) is introduced. The synthesis of CeO2NPs on the BC is performed via a microwave‐assisted, in situ chemical deposition technique, resulting in the formation of mixed valence Ce3+/Ce4+ CeO2NPs. This approach ensures the durability of the composite fabric subjected to multiple washing cycles. The Reactive oxygen species (ROS) scavenging activity of CeO2NPs and their rapid and efficient eradication of >99% model microbes, such as Escherichia coli, Pseudomonas aeruginosa and Staphylococcus aureus remain unaltered in the composite. To demonstrate the feasibility of incorporating the fabric in marketable products, antimicrobial face masks are fabricated with filter layers made of BC@CeO2NPs cross‐linked with propylene or cotton fibers. These masks exhibit complete inhibition of bacterial growth in the three bacterial strains, improved breathability compared to respirator masks and enhanced filtration efficiency compared to single‐use surgical face masks. This study provides valuable insights into the development of functional BC@CeO2NPs biotextiles in which design can be extended to the fabrication of medical dressings and cosmetic products with combined antibiotic, antioxidant and anti‐inflammatory activities.
Intense Left‐handed Circularly Polarized Luminescence in Chiral Nematic Hydroxypropyl Cellulose Composite Films
Authors: Huang Yuxiao , Qian Yi , Chang Yongxin , Yu Jiaqi , Li Qiongya , Tang Mingliang , Yang Xindi , Liu Zhepai , Li Hui , Zhu Zece , Li Wei , Zhang Fusheng , Qing Guangyan 
Published: January 2024

AbstractIntegrating optically active components into chiral photonic cellulose to fabricate circularly polarized luminescent materials has transformative potential in disease detection, asymmetric reactions, and anticounterfeiting techniques. However, the lack of cellulose‐based left‐handed circularly polarized light (L‐CPL) emissions hampers the progress of these chiral functionalizations. Here, this work proposes an unprecedented strategy: incorporating a chiral nematic organization of hydroxypropyl cellulose with robust aggregation‐induced emission luminogens to generate intense L‐CPL emission. By utilizing N,N‐dimethylformamide as a good solvent for fluorescent components and cellulose matrices, this work produces a right‐handed chiral nematic structure film with a uniform appearance in reflective and fluorescent states. Remarkably, this system integrates a high asymmetric factor (0.51) and an impressive emission quantum yield (55.8%) into one fascinating composite. More meaningfully, this approach is versatile, allowing for the incorporation of luminogen derivatives emitting multicolored L‐CPL. These chiral fluorescent films possess exceptional mechanical flexibility (toughness up to 0.9 MJ m−3) and structural stability even under harsh environmental exposures, making them promising for the fabrication of various products. Additionally, these films can be cast on the fabrics to reveal multilevel and durable anticounterfeiting capabilities or used as a chiral light source to induce enantioselective photopolymerization, thereby offering significant potential for diverse practical applications.
Steering CO2 Electroreduction to C2+ Products via Enhancing Localized *CO Coverage and Local Pressure in Conical Cavity
Authors: Li Congcong , Zhang Tingting , Liu Heng , Guo Zhongyuan , Liu Zhongliang , Shi Haojun , Cui Jialin , Li Hao , Li Huihui , Li Chunzhong 
Published: January 2024

AbstractThe electrochemical carbon dioxide (CO2) reduction reaction (CO2RR) involves a multistep proton‐coupled electron transfer (PCET) process that generates a variety of intermediates, making it challenging to transform them into target products with high activity and selectivity. Here, a catalyst featuring a nanosheet‐stacked sphere structure with numerous open and deep conical cavities (OD‐CCs) is reported. Under the guidance of the finite‐element method (FEM) simulations and theoretical analysis, it is shown that exerting control over the confinement space results in diffusion limitation of the carbon intermediates, thereby increasing local pressure and subsequently enhancing localized *CO coverage for dimerization. The nanocavities exhibit a structure‐driven shift in selectivity of multicarbon (C2+) product from 41.8% to 81.7% during the CO2RR process.
3D Printed Sensors for Wearable Electronics and Smart Gesture Recognition
Authors: Wu Qiuping , Ma Duixin , Tao Xingyu , Wu Fengxia , You Guanglin , Wang Bingzhen , Sun Jianping , Shi Shaohong 
Published: January 2024

AbstractModern materials with unique structures and functions are inspired by nature. However, nature's craftsmanship is beyond the reach of traditional handmade techniques. 3D printing technology creates the possibility of creating bionic structures. In this study, inspired by the ability of spiders to sense the capture of prey through the vibration of their webs, a spider‐web‐like, highly sensitive hydrogel sensor is designed and printed. The hydrogel is made of eco‐friendly green polyvinyl alcohol cross‐linked with microcrystalline cellulose. Surprisingly, the 3D‐printed hydrogel sensor can manipulate the sensitivity by changing the angle and strain range of the structure. Accordingly, the Gauge factor (GF) of the 3D‐printed hydrogel (θ = 60°) is up to 58.23, which is 23.9 times higher than that of the non‐3D‐printed hydrogel sensor (GF = 2.43). The GF of the 3D‐printed hydrogel at other angles still remained high at 24.74 (θ = 90°) and 12.31 (θ = 120°), respectively. It can be seen that the 3D‐printed hydrogel sensor has advanced performance. In addition, an intelligent gesture recognition system for human–computer interaction is constructed using 3D‐printed hydrogel sensors, which offers potential prospects for helping people communicate.
Waterproof Room‐Temperature Phosphorescence Films by Host‐Guest Inclusion and Hydrogen Bonding Network
Authors: Liu Jiayi , Liu Shuai , Xu Wensheng , Bo Changchang , Jia Qinglong , Cui Jiaying , Li Tingting , Chen Ligong , Wang Bowei 
Published: January 2024

AbstractSupramolecular room temperature phosphorescence (RTP) materials are attractive due to their excellent RTP characteristics and water resistance. By evaluating the photophysical properties of HA/BisNpI‐doped materials, it is proved that hyaluronic acid (HA) is a promising matrix and the rigid plane N,N′‐(1,4‐phenylene)‐bis(1,8‐naphthalimide) (Ph‐BisNpI) is an excellent luminescent guest molecule for constructing RTP materials. Moreover, it is found that γ‐cyclodextrin (γ‐CD) can successfully bind BisNpI guest molecule. Accordingly, a tightly arranged ternary supramolecular system with HA as matrix, Ph‐BisNpI as the guest, and γ‐CD as the host is constructed by host‐guest interaction and hydrogen bonding. As expected, the obtained ternary supramolecular system HA/Ph@CD8 displays a superior RTP performance (52.7 ms longer lifetime than HA/Ph), water‐resistance, and even aqueous RTP (τ = 207 µs), which significantly extends the application of RTP in aqueous solution. These results are possibly attributed to the inclusion of γ‐CD on Ph‐BisNpI guest molecules and the self‐assembly of γ‐CD and HA to form a rigid hydrogen bonding network, which effectively inhibits the non‐radiative decay of Ph‐BisNpI and shields the triplet excitons from water and oxygen. Furthermore, the prepared ternary supramolecular RTP materials are successfully used as anticounterfeiting ink and exhibit broader application prospects in water environments.
Oleo‐Dispersions of Electrospun Cellulose Acetate Butyrate Nanostructures: Toward Renewable Semisolid Lubricants
Authors: Martín‐Alfonso Manuel A. , Rubio‐Valle José F. , Martín‐Alfonso José E. , Franco José M. 
Published: January 2024

AbstractIn this work, the electrospinnability of cellulose acetate butyrate (CAb) solutions, and the ability of the resulting micro‐ and nano‐architectures to structure castor oil are studied aiming to develop eco‐friendly lubricating greases. Particles, beaded‐fibers, defect‐free fibers, and porous nanostructures are successfully prepared by dissolving CAb in N,N‐dimethylacetamide/acetone (DMAc:Ac, 1:2 w/w) and methylene chloride/acetone (DM:Ac, 1:1 w/w) solvent mixtures at different concentrations (2.5–15 wt.%). The formation of bead‐free nanofibers is favored at concentration above 10 wt.%, when solutions achieve relaxation times of ≈50 ms and shear‐thinning in extensional and shear flow tests, respectively. Non‐porous and porous CAb nanostructures are successfully used as castor oil thickeners at concentrations of 3–5 wt.%, leading a wide variety of rheological responses which mimic those of traditional semisolid lubricants. The surface properties of the nanofibers have a significant impact on the wear and friction performance in metal–metal contact, which has been associated with the oil release ability of the generated 3D network. Oleo‐dispersions prepared with smooth fibers show tribological performance comparable to, or even better than, commercial lithium greases. Overall, this study reveals the potential of CAb electrospun nanostructures for the development of next‐generation renewable semisolid lubricant formulations.
De Novo Atomistic Discovery of Disordered Mechanical Metamaterials by Machine Learning
Authors: Liu Han , Li Liantang , Wei Zhenhua , Smedskjaer Morten M. , Zheng Xiaoyu Rayne , Bauchy Mathieu 
Published: January 2024

AbstractArchitected materials design across orders of magnitude length scale intrigues exceptional mechanical responses nonexistent in their natural bulk state. However, the so‐termed mechanical metamaterials, when scaling bottom down to the atomistic or microparticle level, remain largely unexplored and conventionally fall out of their coarse‐resolution, ordered‐pattern design space. Here, combining high‐throughput molecular dynamics (MD) simulations and machine learning (ML) strategies, some intriguing atomistic families of disordered mechanical metamaterials are discovered, as fabricated by melt quenching and exemplified herein by lightweight‐yet‐stiff cellular materials featuring a theoretical limit of linear stiffness–density scaling, whose structural disorder—rather than order—is key to reduce the scaling exponent and is simply controlled by the bonding interactions and their directionality that enable flexible tunability experimentally. Importantly, a systematic navigation in the forcefield landscape reveals that, in‐between directional and non‐directional bonding such as covalent and ionic bonds, modest bond directionality is most likely to promotes disordered packing of polyhedral, stretching‐dominated structures responsible for the formation of metamaterials. This work pioneers a bottom‐down atomistic scheme to design mechanical metamaterials formatted disorderly, unlocking a largely untapped field in leveraging structural disorder in devising metamaterials atomistically and, potentially, generic to conventional upscaled designs.
Variation, sexual dimorphism, and enlargement of the frontal sinus with age in adult South Africans
Authors: Greening Victoria A. , Hernandez Emily , Mongle Carrie S. , Billings Brendon K. , Mngomezulu Victor , Wallace Ian J. , Grine Frederick E. 
Published: January 2024

AbstractObjectivesTo document frontal sinus volume (FSV) in a sample of sub‐Saharan Africans with a view to evaluating claims that such populations exhibit comparatively small sinuses. This study also addresses questions related to sexual dimorphism, incidence of sinus aplasia, and the possibility that FSV continues to increase through adulthood.Materials and methodsFSV was measured from CT scans of adult crania from the Dart Collection. Sex and age were known for each individual. Linear cranial dimensions were used to compute a geometric mean from which a scaled FSV was computed for each cranium.ResultsFSV does not differ significantly between sexes, but females exhibit a higher incidence of aplasia. There is considerable variation in FSV in this sample, with the average ranking among the higher means reported for other population samples. The incidence of FS aplasia falls within the range of values recorded for other population samples. Although our study is cross‐sectional rather than longitudinal, there is strong evidence that FSV continues to increase with age throughout adulthood.DiscussionThe FSV mean of our sample contradicts the notion that sub‐Saharan Africans possess small sinuses. In a global context, geography (climate and altitude) does not appear to be related to FSV. The absence of sexual dimorphism in our sample is unexpected, as significant dimorphism has been reported for most other population samples. Our results support other indications that the frontal sinus continues to expand throughout adulthood, especially in females, and that it is likely due to bone resorption.
Quantitative assessment of grasping strength in platyrrhine monkeys
Authors: Young Jesse W. , Chadwell Brad A. , O'Neill Timothy P. , Pastor Francisco , Marchi Damiano , Hartstone‐Rose Adam 
Published: January 2024

AbstractObjectivesDespite the longstanding importance of grasping adaptations in theories of primate evolution, quantitative data on primate grasping strength remain rare. We present the results of two studies testing the prediction that callitrichines—given their comparative retreat from a small‐branch environment and specialization for movement and foraging on tree trunks and large boughs—should be characterized by weaker grasping forces and underdeveloped digital flexor muscles relative to other platyrrhines.MethodsFirst, we directly measured manual grasping strength in marmosets (Callithrix jacchus) and squirrel monkeys (Saimiri boliviensis), using a custom‐constructed force transducer. Second, we reanalyzed existing datasets on the fiber architecture of forearm and leg muscles in 12 platyrrhine species, quantifying digital flexor muscle physiological cross‐sectional area (i.e., PCSA, a morphometric proxy of muscle strength) relative to the summed PCSA across all forearm or leg muscles.ResultsCallithrix was characterized by lower mean and maximum grasping forces than Saimiri, and callitrichines as a clade were found to have relatively underdeveloped manual digital flexor muscle PCSA. However, relative pedal digital flexor PCSA did not significantly differ between callitrichines and other platyrrhines.ConclusionsWe found partial support for the hypothesis that variation in predominant substrate usage explains variation in empirical measurements of and morphological correlates of grasping strength in platyrrhines. Future research should extend the work presented here by (1) collecting morphological and empirical metrics of grasping strength in additional primate taxa and (2) extending performance testing to include empirical measures of primate pedal grasping forces as well.
2D Metal/Graphene and 2D Metal/Graphene/Metal Systems for Electrocatalytic Conversion of CO2 to Formic Acid
Authors: Cho Jinwon , Medina Arturo , Saih Ines , Il Choi Ji , Drexler Matthew , Goddard William A. , Alamgir Faisal M. , Jang Seung Soon 
Published: January 2024

AbstractEfficiently transforming CO2 into renewable energy sources is crucial for decarbonization efforts. Formic acid (HCOOH) holds great promise as a hydrogen storage compound due to its high hydrogen density, non‐toxicity, and stability under ambient conditions. However, the electrochemical reduction of CO2 (CO2RR) on conventional carbon black‐supported metal catalysts faces challenges such as low stability through dissolution and agglomeration, as well as suffering from high overpotentials and the necessity to overcome the competitive hydrogen evolution reaction (HER). In this study, we modify the physical/chemical properties of metal surfaces by depositing metal monolayers on graphene (M/G) to create highly active and stable electrocatalysts. Strong covalent bonding between graphene and metal is induced by the hybridization of sp and d orbitals, especially the sharp
,
, and
orbitals of metals near the Fermi level, playing a decisive role. Moreover, charge polarization on graphene in M/G enables the deposition of another thin metallic film, forming metal/graphene/metal (M/G/M) structures. Finally, evaluating overpotentials required for CO2 reduction to HCOOH, CO, and HER, we find that Pd/G, Pt/G/Ag, and Pt/G/Au exhibit excellent activity and selectivity toward HCOOH production. Our novel 2D hybrid catalyst design methodology may offer insights into enhanced electrochemical reactions through the electronic mixing of metal and other p‐block elements.