bluuebunny/crossref_metadata_2025_split huggingface dataset:
Gibberellin promotes cambium reestablishment during secondary vascular tissue regeneration after girdling in an auxin‐dependent manner in Populus
Authors: Zhang Yufei , Wang Lingyan , Wu Yuexin , Wang Donghui , He Xin‐Qiang 
Published: December 2023

ABSTRACTSecondary vascular tissue (SVT) development and regeneration are regulated by phytohormones. In this study, we used an in vitro SVT regeneration system to demonstrate that gibberellin (GA) treatment significantly promotes auxin‐induced cambium reestablishment. Altering GA content by overexpressing or knocking down ent‐kaurene synthase (KS) affected secondary growth and SVT regeneration in poplar. The poplar DELLA gene GIBBERELLIC ACID INSENSITIVE (PtoGAI) is expressed in a specific pattern during secondary growth and cambium regeneration after girdling. Overexpression of PtoGAI disrupted poplar growth and inhibited cambium regeneration, and the inhibition of cambium regeneration could be partially restored by GA application. Further analysis of the PtaDR5:GUS transgenic plants, the localization of PIN‐FORMED 1 (PIN1) and the expression of auxin‐related genes found that an additional GA treatment could enhance the auxin response as well as the expression of PIN1, which mediates auxin transport during SVT regeneration. Taken together, these findings suggest that GA promotes cambium regeneration by stimulating auxin signal transduction.
Migration and the location of MNE activities: Evidence from Italian provinces
Authors: Benfratello Luigi , Castellani Davide , D'Ambrosio Anna 
Published: December 2023

AbstractWe investigate the migration‐inward foreign direct investment (FDI) nexus in narrow geographies. A novel two‐stage empirical strategy allows us to investigate the role of migration as a determinant of multinational enterprises (MNEs) location choices and unpick heterogeneity in foreign investors' preferences towards the presence of migrants in the host location. This allows us to shed light on the relative importance of the underlying mechanisms linking migration and inward FDI. Relying on 1113 greenfield investments by 895 MNEs in Italian NUTS3 regions over 2003–2015, we find that immigrants from the country of origin of the investor exert a positive but highly heterogeneous effect on MNE location choices. Investors are more sensitive to the presence of migrants from their country of origin when they lack experience in the destination country (first‐time investors) and when their investments concern market‐access or business‐services (downstream) activities. This is consistent with the view that migrants act as information brokers that bridge the fixed costs of international business activities.
What difference does sleep make? Continuous glucose monitoring metrics during fixed‐overnight time versus sleep periods among older adults with type 1 diabetes
Authors: Trawley Steven , Kubilay Erin , Colman Peter G. , Lee Melissa H. , O'Neal David N. , Sundararajan Vijaya , Vogrin Sara , McAuley Sybil A. 
Published: December 2023

SummaryHypoglycaemia during sleep is a common and clinically important issue for people living with insulin‐treated diabetes. Continuous glucose monitoring devices can help to identify nocturnal hypoglycaemia and inform treatment strategies. However, sleep is generally inferred, with diabetes researchers and physicians using a fixed‐overnight period as a proxy for sleep–wake status when analysing and interpretating continuous glucose monitoring data. No study to date has validated such an approach with established sleep measures. Continuous glucose monitoring and research‐grade actigraphy devices were worn and sleep diaries completed for 2 weeks by 28 older adults (mean age 67 years [SD 5]; 17 (59%) women) with type 1 diabetes. Using continuous glucose monitoring data from a total of 356 nights, fixed‐overnight (using the recommended period of 00:00 hours–06:00 hours) and objectively‐measured sleep periods were compared. The fixed‐overnight period approach missed a median 57 min per night (interquartile range: 49–64) of sleep for each participant, including five continuous glucose monitoring‐detected hypoglycaemia episodes during objectively‐measured sleep. Twenty‐seven participants (96%) had at least 1 night with continuous glucose monitoring time‐in‐range and time‐above‐range discrepancies both ≥ 10 percentage points, a clinically significant discrepancy. The utility of fixed‐overnight time continuous glucose monitoring as a proxy for sleep–awake continuous glucose monitoring is inadequate as it consistently excludes actual sleep time, obscures glycaemic patterns, and misses sensor hypoglycaemia episodes during sleep. The use of validated measures of sleep to aid interpretation of continuous glucose monitoring data is encouraged.
Intention‐aware robot motion planning for safe worker–robot collaboration
Authors: Liu Yizhi , Jebelli Houtan 
Published: December 2023

AbstractRecent advances in robotics have enabled robots to collaborate with workers in shared, fenceless workplaces in construction and civil engineering, which can improve productivity and address labor shortages. However, this collaboration may lead to collisions between workers and robots. Targeting safe collaboration, this study proposes an intention‐aware motion planning method for robots to avoid collisions. This method involves two novel deep networks that allow robots to anticipate the motions of workers based on inferences about workers' motion intentions. Then, a probabilistic collision‐checking mechanism is developed that enables robots to estimate the collision probability with the motions of workers and generate collision‐free adjustments. The results verify that the method enables robots to predict workers' intended motions 1 s in advance and generate adjustments with a collision probability of less than 5.0% during collaborative masonry tasks. This study facilitates the safe implementation of collaborative robots in construction and civil engineering.
Association of bariatric surgery with indicated and unintended outcomes: An umbrella review and meta‐analysis for risk–benefit assessment
Authors: Kim Min Seo , Kim Jong Yeob , Song Yong Shin , Hong Seokwon , Won Hong‐Hee , Kim Won Jun , Kwon Yeongkeun , Ha Jane , Fiedorowicz Jess G. , Solmi Marco , Shin Jae Il , Park Sungsoo , Rosenthal Raul J. 
Published: December 2023

SummaryBariatric surgery can cause numerous functional changes to recipients, some of which are unintended. However, a systematic evaluation of wide‐angled health benefits and risks following bariatric surgery has not been conducted. We systematically evaluated published systematic reviews of randomized controlled trials and observational studies reporting the association between bariatric surgery and health outcomes. We performed subgroup analyses by surgery type and sensitivity analysis, excluding gastric band. Thirty systematic reviews and 82 meta‐analyzed health outcomes were included in this review. A total of 66 (80%) health outcomes were significantly associated with bariatric surgery, of which 10 were adverse outcomes, including suicide, fracture, gastroesophageal reflux after sleeve gastrectomy, and neonatal morbidities. The other 56 outcomes were health benefits including new‐onset diabetes mellitus (DM) (odds ratio [OR] = 0.39; 95% confidence interval [CI] = 0.19–0.79), hypertension (OR = 0.36; 95% CI = 0.33–0.40), dyslipidemia (OR = 0.33; 95% CI = 0.14–0.81), cancers (OR = 0.65; 95% CI = 0.53–0.80), cardiovascular diseases (CVDs), and women's health. Surgery is associated with reductions in all‐cause mortality and death due to cancer, DM, and CVD. Bariatric surgery has both beneficial and harmful effects on a broader than expected array of patients' health outcomes. An expansion of the indication for bariatric surgery could be discussed to include a broader population with metabolic vulnerabilities.
Characterization of temperate and tropical popcorn populations and GWAS for zeins and starch contents
Authors: Gotardi Leonardo Fioravante , Viana José Marcelo Soriano , Ribeiro Matheus Pereira , de Castro Raissa Barbosa , de Oliveira Ramos Humberto Josué , Fietto Juliana Lopes Rangel 
Published: December 2023

AbstractBecause measuring expansion volume (EV) is simple and inexpensive, popcorn breeders have developed high‐quality single crosses ignoring the contents of zeins, starch, lipids, and cellular wall components in selection. However, some methods of quantification of these quality‐related traits can be applied to popcorn breeding, increasing the selection efficacy for quality. The objectives of this study were to assess methods of zeins and starch quantification that can be used in popcorn breeding, characterize a temperate and a tropical populations for zeins and starch contents and identify candidate genes for these quality‐related traits. We genotyped and phenotyped 286 plants. For quantification of total zeins and zein subunits we choose the ‘lab‐on‐a‐chip’ microfluidic electrophoresis. For quantification of starch and amylose/amylopectin, we choose the Megazyme's Amylose/Amylopectin kit assay. The temperate population has superior EV (36.0%), a higher level of the 19 kDa zein subunit (32.0%), lower levels of the 21, 22 and 27 kDa subunits (−1543.0%, −40.0% and −47.0%, respectively) and no statistical difference for the 10 kDa zein content, relative to the tropical population. Although there are statistical differences between the two populations regarding starch, amylose, and amylose/amylopectin ratio, the differences are not significant (−2.0% to 8.0%). Thirteen candidate genes were identified for the 19 and 22 kDa zeins, two for amylose and one for starch, with emphasis on the genes coding for the 19 and 22 kDa alpha‐zeins, located on chromosome 4. The evaluated quantification methods can be used in popcorn breeding but for a limited number of samples, mainly because costs.
Effects of reminiscence therapy on cognition, agitation, and quality of life in older adults with dementia receiving long‐term care
Authors: Bayram Serap 
Published: December 2023

AbstractBackgroundDementia is one of the most common neuropsychiatric conditions in older adults. Despite many older adults with dementia receiving long‐term care (LTC), few studies have been conducted in Turkey on reminiscence therapy (RT) influencing neuropsychiatric symptoms and quality of life in people with dementia receiving LTC. This study aimed to investigate the effect of RT on cognition, agitation, and quality of life in older adults with dementia receiving LTC in Turkey.MethodsThe study population consisted of 100 older adults living in a LTC centre in a province. The size of the research group was calculated using the power analysis method, and 54 older adults were included in the study, 27 each in the RT and control (C) groups. Data collection forms Mini‐Mental State Examination (MMSE), Cohen‐Mansfield Agitation Inventory (CMAI), and the Alzheimer's Disease Quality‐of‐Life Scale (AD‐QOL) were applied to the RT and C groups before RT (T0), 1 week after RT (T1), 1 month after RT (T2), and 3 months after RT (T3) to evaluate the effectiveness of the intervention. Mean, standard deviation, ratio, percentile, Fisher's exact test, Pearson Chi‐square test, Mann–Whitney U‐test, and Friedman test were used in analyzing the data.ResultsOlder adults in the RT and C groups were similar regarding sociodemographic characteristics, institutional care, and life models (P > 0.05). When comparing the T3 values of MMSE, CMAI, and AD‐QOL total scores with the T0 values, a significant difference was observed between the groups, favouring the RT group (P < 0.001).ConclusionIndividual RT may benefit cognition, agitation, and quality of life of older adults with dementia residing in a LTC centre.
The Uses of Rupture in Medieval Northern Eurasian History
Authors: Evans Nick 
Published: December 2023

AbstractWill Russia’s invasion of Ukraine change bring about a rupture in how we write about and teach the history of medieval Northern Eurasia? Dominant accounts of the region’s medieval history invoke ruptures, such as the Mongol invasion, in the service of state‐centred narratives. Such narratives obscure the diversity of the region’s past and its present. This essay explores the uses of rupture in the historiography of medieval Northern Eurasia. It shows how modern readings of chronicles produced within the monasteries of medieval northern Eurasia have used the device of rupture in the service of a variety of different imperial, national, liberal and conservative historical narratives. This tendency has been remarkably resilient, across modern ruptures such as 1917 and 1991. The essay also addresses the problematic legacy of “Eurasianist” ideas, while pointing to a counter‐tradition of Northern Eurasian historiography, which could provide rich resources for a less ethnocentric and statist approach to the region today. The essay concludes by considering the opportunities for such an approach, in the light of current academic disciplinary boundaries, and media‐ and policy‐facing commentary on the region.
Towards standardized human platelet lysate production in Europe: An initiative of the European Blood Alliance
Authors: De Korte Dirk , Delabie Willem , Feys Hendrik B. , Klei Thomas , Larsen Rune , Sigurjónsson Ólafur , Sousa Ana Paula ,   the European Blood Alliance
Published: December 2023

AbstractHuman platelet lysate (hPL) is a supplement for cell culture media that can be derived from platelet concentrates. As not‐for‐profit blood establishments, we endorse the evolution of maximally exploiting the potential of donated blood and its derived components, including platelets. The decision to use platelet concentrates to supply hPL as a cell culture supplement should align with the principles and values that blood establishments hold towards the use of donated blood components in transfusion. As a consequence, questions on ethics, practical standardization of hPL production and logistics as well as on assuring hPL quality and safety need careful consideration. We therefore propose an opinion on some of these matters based on available literature and on discussions within the proceedings of the Working Group on Innovation and New Products of the European Blood Alliance. In addition, we propose collaboration among European blood establishments to streamline efforts of hPL supply to maximize the potential of hPL and its application in the wider field of medicine.
Algebraic theories of power operations
Authors: Balderrama William 
Published: December 2023

AbstractWe develop and exposit some general algebra useful for working with certain algebraic structures that arise in stable homotopy theory, such as those encoding well‐behaved theories of power operations for ring spectra. In particular, we consider Quillen cohomology in the context of algebras over algebraic theories, plethories, and Koszul resolutions for algebras over additive theories. By combining this general algebra with obstruction‐theoretic machinery, we obtain tools for computing with algebras over and over Lubin–Tate spectra. As an application, we demonstrate the existence of periodic complex orientations at heights .
Trace embeddings from zero surgery homeomorphisms
Authors: Nakamura Kai 
Published: December 2023

AbstractManolescu and Piccirillo (2023) recently initiated a program to construct an exotic or by using zero surgery homeomorphisms and Rasmussen's ‐invariant. They find five knots that if any were slice, one could construct an exotic and disprove the Smooth 4‐dimensional Poincaré conjecture. We rule out this exciting possibility and show that these knots are not slice. To do this, we use a zero surgery homeomorphism to relate slice properties of two knots stably after a connected sum with some 4‐manifold. Furthermore, we show that our techniques will extend to the entire infinite family of zero surgery homeomorphisms constructed by Manolescu and Piccirillo. However, our methods do not completely rule out the possibility of constructing an exotic or as Manolescu and Piccirillo proposed. We explain the limits of these methods hoping this will inform and invite new attempts to construct an exotic or . We also show that a family of homotopy spheres constructed by Manolescu and Piccirillo using annulus twists of a ribbon knot are all standard.
Hsa_circ_0007321 regulates Zika virus replication through miR-492/NFKBID/NF-κB signaling pathway
Authors: Kang Lan , Xie He , Ye Haiyan , Jeyarajan Andre J. , Warner Charlotte A. , Huang Yike , Shi Yaoqiang , Li Yujia , Yang Chunhui , Xu Min , Lin Wenyu , Sun Jujun , Chen Limin , Duan Xiaoqiong , Li Shilin 
Published: December 2023

ABSTRACT
Circular RNAs (CircRNAs) have been shown to play a critical role in regulating viral infection and replication. We performed RNA sequencing to identify differentially expressed circRNAs in A549 human lung adenocarcinoma cells with and without Zika virus (ZIKV) infection. Notably, hsa_circ_0007321 was significantly downregulated after ZIKV infection. We then explored the role and mechanism of hsa_circ_0007321 in the regulation of ZIKV replication. Hsa_circ_0007321, derived from exons 2, 3, 4, and 5 of the DIS3L2 (DIS3 like 3'−5' exoribonuclease 2) gene, was mainly enriched in cytoplasm. We found that the knockdown of hsa_circ_0007321 significantly increased microRNA-492 levels to decrease NFKBID (NFKB inhibitor delta) expression, leading to the activation of the nuclear factor-κB (NF-κB) signaling pathway, inflammatory cytokine production, and subsequently, inhibition of ZIKV replication. These findings illustrate that hsa_circ_0007321 acts as a competitive endogenous RNA that regulates ZIKV replication through the miR-492/NFKBID NF-κB signaling pathway.

IMPORTANCE
Over the past decade, increasing evidence has shown that circular RNAs (circRNAs) play important regulatory roles in viral infection and host antiviral responses. However, reports on the role of circRNAs in Zika virus (ZIKV) infection are limited. In this study, we identified 45 differentially expressed circRNAs in ZIKV-infected A549 cells by RNA sequencing. We clarified that a downregulated circRNA, hsa_circ_0007321, regulates ZIKV replication through targeting of miR-492 and the downstream gene NFKBID. NFKBID is a negative regulator of nuclear factor-κB (NF-κB), and we found that inhibition of the NF-κB pathway promotes ZIKV replication. Therefore, this finding that hsa_circ_0007321 exerts its regulatory role on ZIKV replication through the miR-492/NFKBID/NF-κB signaling pathway has implications for the development of strategies to suppress ZIKV and possibly other viral infections.
Complete genome sequences of cluster F1 and cluster B1
Mycobacterium smegmatis
phages Karhdo and Basato
Authors: Kim Jireh , Herrera Carlos , Aung Wai Yan , Gonzales Boyles Gino Pablo , Chavez Carmina , Cibulka Mona , Foley Emma , Guerra Jose , Kumar Disha Byadarahalli Mohan , Levrant Willow , Lim Lewis , Llanes Jose , O'Brien Zachary Kamuela , Pagaduan Art , Richardson Justin Aaron , Rosales Khristian , Schrecengost James , Shin Tommy , Strong-Lundquist Gabriel , Tat Winnie , Vanderford Fritz , Vrinceanu Isabelle , Wang Vicky , Yang Stephanie , Strong Christy , Tsourkas Philippos K. , Regner Kurt 
Published: December 2023

ABSTRACT

We present the complete genome sequences of
Mycobacterium smegmatis
phages Karhdo and Basato, isolated in Clark County, Nevada. The phages were isolated and annotated by students enrolled in undergraduate research courses over two semesters at the University of Nevada, Las Vegas.
Epidemiological characteristics of respiratory viruses in children during the COVID-19 epidemic in Chengdu, China
Authors: Gao Zheng-Xiang , Wang Ya , Yan Ling-Yi , Liu Ting , Peng Lei-Wen 
Published: December 2023

ABSTRACT

The purpose of this retrospective study was to analyze the prevalence of respiratory viruses among children with acute respiratory tract infections (ARTIs) during the coronavirus disease 2019 epidemic (1 March 2020–28 February 2022). This study investigated respiratory viral specimens from children with ARTIs. A total of 7,092 children (<14 years) with ARTIs were included in this study, with a boy-to-girl ratio of 1.43. The median age was 1 year and 5 months. The average age of the patients was 2.7 ± 3.1 years. Patients < 3 years of age were the main population with ARTIs (67%). The predominant viruses were respiratory syncytial virus (RSV) (10.1%) and influenza virus (A and B 9.7%) during the 2 years of the pandemic (1 March 2020–28 February 2022). The proportion of positive viral test results among patients with ARTIs < 6 years of age was higher than that among patients with ARTIs aged 6–14 years (17.3% vs. 5.7%,
P
< 0.01). RSV infections were more common among patients < 3 years of age (
P
< 0.01). Influenza A infections were more common among patients aged 3–6 years (
P
< 0.01). Influenza B infections were more common among patients aged 6–14 years (
P
< 0.01). The positive proportion among boys was higher than that among girls (14.4% vs. 8.6%,
P
< 0.01). Peak virus infections occurred in the autumn and winter seasons, and the lowest activity level occurred in the spring and summer of the 2 years. Compared with that before the epidemic, the number of samples and positive proportion of respiratory viruses decreased significantly.

IMPORTANCE
During the coronavirus disease 2019 epidemic, the Chinese government launched and used a series of nonpharmaceutical interventions (NPIs), including banning social gatherings, wearing face masks, home isolation, and maintaining hand hygiene, to control the disease spread. Whether and how NPIs influence other respiratory viruses in children remain unclear. In this article, we analyzed relative data and found that the number of samples and positive proportion of respiratory viruses decreased significantly compared with that before the epidemic. Clinicians and public health policymakers should pay attention to changes in the epidemic trends and types of respiratory viruses and maintain monitoring of respiratory-related viruses to avoid possible abnormal rebounds and epidemic outbreaks of these viruses.