bluuebunny/crossref_metadata_2025_split huggingface dataset:
Hospital and long-term periods of myocardial infarction in comorbid men and women under 60 years
Authors: Zykov M. V. , Sedykh D. Yu. , Barbarash O. L. 
Published: December 2023

Aimof the study was to assess the impact of comorbidity on the hospital and 2-year stage of treatment for myocardial infarction (MI) in men and women under 60 years of age.Material and methods. The analysis included 350 patients with MI younger than 60 years of age. The majority of patients (87.4 %) were men. For all patients, the risk was calculated according to the GRACE ASC Risk Model scale and an analysis was made of the severity of comorbidity according to the own model “K9” (patent RU2734993C1 from October 27, 2020), based on the summation of 9 diseases: diabetes mellitus, atrial fibrillation, stroke, arterial hypertension, obesity, peripheral atherosclerosis, thrombocytopenia, anemia, chronic kidney disease.Results.Comorbidity (the presence of 2 or more diseases) was recorded insignificantly more often in men (65.9 % versus 53.6 %, p = 0.12). In men, but not in women, comorbidity was associated with a 23.5 % reduction in percutaneous coronary intervention (p = 0.006). Both in-hospital mortality and the risk of major cardiovascular events (death/MI/stroke) 2 years after discharge were minimal (up to 0.7 % and up to 8.1 %, respectively) in the absence of comorbidity in both men and women, higher in comorbid women (3.4 and 12.5 %, respectively) and maximum in comorbid men (6.1 and 18.4 %, respectively). Comorbidity more significantly aggravated the 2-year prognosis in patients undergoing percutaneous coronary intervention than in receiving primary conservative treatment, increasing the risk of developing the death/MI/stroke end point by 3 times (16.7 and 5.8 %, respectively, p = 0.013). The addition of comorbidity data to the GRACE scale in the Cox regression analysis can significantly improve the prognosis of the onset of the 2-year endpoint, increasing the χ2value from 64.08 to 79.86, and the value of the area under the ROC-curve (AUC) to 0.79 (95 % confidence interval (95 % CI) 0.71–0.88). At the same time, ROC analysis showed that the modified GRACE scale predicts the onset of the death/ MI/stroke endpoint in men much better than in women: AUC 0.81 (95 % CI 0.72–0.90) and AUC 0.67 (95 % CI 0.51–0.83), respectively.Conclusions.Comorbidity is comparable to the GRACE scale and effectively predicts the likelihood of hospital mortality. At the same time, the GRACE scale has an unsatisfactory predictive value for the 2-year endpoint “death/MI/stroke”. Modification of the GRACE scale with data on comorbidity has important clinical implications in men, but not in women, allowing more effective stratification of the risk of adverse events in the long term after myocardial infarction.
Association of <i>CSK, MTHFR, ACE, ADRA2B, TCF7L2</i> gene polymorphisms with dyslipidemia among indigenous and non-indigenous people of Khanty-Mansy Autonomous Okrug – Yugra
Authors: Korneeva E. V. , Voevoda M. I. , Semaev S. E. , Maksimov V. N. 
Published: December 2023

The increase in cardiovascular diseases and their complications, diabetes mellitus and metabolic syndrome determines the relevance of early diagnosis and prevention of lipid metabolism disorders by identifying and studying genetic markers of predisposition to dyslipidemia in various populations depending on gender, age and ethnicity.Aim of the study was to investigate the associations of candidate genes CSK, MTHFR, ACE, ADRA2B and TCF7L2 with dyslipidemia in the young indigenous and non-indigenous population living in the Khanty-Mansy autonomous Okrug – Ugra.Material and methods. 863 young people aged 18–44 years were examined, clinical population included nonindigenous and indigenous men and women with metabolic syndrome (n = 344), the comparison group included non-indigenous and indigenous men and women without metabolic syndrome (n = 519). A study of the lipid profile and molecular genetic study was carried out using the polymerase chain reaction method for single nucleotide polymorphisms (SNPs): rs1378942 of the gene CSK, rs1801133 (C677T) of the gene MTHFR, gene ADRA2B, rs7903146 of the gene TCF7L2, rs1799752 of the gene ACE.Results. A high frequency of hypercholesterolemia (79.0 %) and hypertriglyceridemia (65.8 %) was found in the examined men and women. Statistically significant differences were established in the frequency of dyslipidemia in patients with metabolic syndrome by ethnicity and gender (p < 0.001). In the general cohort of men with metabolic syndrome hypercholesterolemia is associated with the TT genotype of SNP rs1801133 (C677T) of the gene MTHFR (p = 0.039), in the women – with the DD genotype of the gene ADRA2B (p = 0.010). In indigenous men of the clinical group an association of hypercholesterolemia with the minor T allele of the gene MTHFR (p = 0.005), of hypertriglyceridemia – with the minor T allele of the gene MTHFR (p = 0.031) and the T allele of the gene TCF7L2 (p = 0.031) was revealed. Among indigenous women of the clinical group hypercholesterolemia is associated with carriage of the minor T allele of the gene CSK (p < 0.001) and hypertriglyceridemia – with the D allele of the gene ADRA2B (p = 0.046).Conclusions. Carriage of minor alleles T of the MTHFR gene and D of the ADRA2B gene is associated with hypercholesterolemia among the examined young people and is statistically significantly higher in the group of patients with metabolic syndrome, as well as among indigenous residents of the KhantyMansiysk Autonomous Okrug – Ugra.
Origin and formation of early changes in the retina under the influence of atherosclerosis factors
Authors: Lazutkina A. Yu. 
Published: December 2023

Lesions of the microcirculatory bed of the retina are an urgent problem due to their prevalence, severity of irreversible changes and their association with an unfavorable cardiovascular prognosis. Their pathogenesis is associated with endothelial dysfunction. Determining the processes of the formation and progression of retinopathy (RP) will bring closer the solution of problematic issues in ophthalmology and cardiology, and reduce cardiovascular morbidity and mortality.Aim. To study the processes of formation and progression of retinopathy in the initial stages of mixed origin (hypertensive, diabetic, unspecified etiology).Material and methods. The origin and progression of I–II degree RP under the influence of predictors of this symptom has been revealed through statistical analysis using the data of the 2008–2013 prospective follow-up of 22 clinical indicators of a natural group of initially healthy 7.959 male workers of locomotive crews of the Trans-Baikal Railway aged 18–66 years. Multivariate stepwise analysis, a 2 × 2 confusion matrix, Cox and Kaplan-Meier proportional hazard models were used, and a relative risk was assessed.Results. Such predictors of grade I–II RP as arterial hypertension, I–III degree obesity, smoking, dyslipidemia, left ventricular hypertrophy, family history of early cardiovascular disease, hyperglycemia, aortic atherosclerosis, creatininemia, atherosclerotic plaque / intima-media complex thickening, microalbuminuria, type 2 diabetes mellitus and age showed statistical heterogeneity in mathematical models. The distinctive feature was the different mutually exclusive assessment of the predictors’ significance in the models used. Thus, the predictors of I–II degree RP showed their specific identification characteristics, defined in qualitative and quantitative dimensions, by which they could be found and studied in the cell as well as their damaging effect.Conclusions. The course of endothelial dysfunction varies significantly when influenced by RP predictors. Its manifestations are determined by the influence of a specific factor, a set of factors or by all predictors taken together and involved simultaneously. This shows the need to determine the qualitative and quantitative ultrastructural and biochemical specific markers of endothelial dysfunction of the microvasculature of the eye appearing under the influence of RP predictors during the formation and progression of this pathological symptom in order to restore the normal function of the endothelial cell and the affected organ as a whole, as long as there is still room for therapeutic efforts.
Sex differences in adherence to treatment in patients with myocardial infarction
Authors: Sedykh D. Yu. , Barbarash O. L. 
Published: December 2023

The aim of the study is to identify factors affecting adherence to treatment in men and women with myocardial infarction (MI).Material and methods. The study included 150 patients diagnosed with MI (47 women and 103 men). Treatment readiness was assessed according to the S.V. Davydov method and with the calculation of the integral indicator of adherence to treatment (IIAT).Results. During 6-month follow-up, men and women with MI were comparable in mortality rates, however, men were more frequently hospitalized for cardiovascular complications. Adherence to treatment was high in both genders. Treatment readiness at the time of MI indicated higher satisfaction with the results of treatment in women, and higher willingness to pay for treatment, higher confidence in the treatment strategy and a higher IIAT in men. Both women and men with MI reported a comparable number of outpatient visits within 6 months (not exceeding 56 %). Only small number of patients reached the target heart rate (HR) and low-density lipoprotein (LDL) content within 6 months. Patients of both genders who reached and not reached the target LDL level and HR did not differ in mortality rates, hospitalizations and adherence to treatment within 6 months. At the same time, patients who reached the target HR, regardless of gender, were more likely to make outpatient postMI visits compared with those who did not reach the targets; men with MI who did not achieve the target HR were less likely to visit a doctor, whereas women with MI who achieved the target HR and LDL were more likely to have a high IIAT during in-patient care and were more willing to pay for further treatment (an exclusive characteristic of women who reached target HR). Moreover, we have identified predictors of IIAT and achievement of HR and LDL in women and men with MI.Conclusions. Patients with MI present with sex-specific factors that are affecting treatment adherence, which should be accounted for in the development of measures for secondary prevention of disease.
Estimación del potencial energético (calor y electricidad) del estiércol bovino en Nicaragua 2023
Authors: Díaz Robleto Marlon José 
Published: December 2023

Según la Organización de las Naciones Unidas para la Agricultura y la Alimentación (FAO) la ganadería es una de las principales causas de degradación del suelo y recursos hídricos, además genera más gases de efecto invernadero (GEI) que el sector transporte, debido entre otras causas a los volúmenes de excretas generadas. En Nicaragua el sector ganadero es uno de los principales contribuyentes al desarrollo económico del país, siendo el principal emisor de GEI causado por la fermentación entérica (metano). El objetivo de esta investigación fue presentar una prospección con base en fundamentos teóricos internacionalmente aceptados para realizar estimaciones de la generación entérica de metano a causa de las deposiciones de estiércol del ganado, así mismo se utilizó literatura nacional conteniendo cálculos utilizados en estudios de caso y proyectos pilotos ejecutados, con ese respaldo teórico se estimó el potencial energético (calor y electricidad) de las excretas del ganado bovino de Nicaragua. El enfoque de la investigación fue cuantitativo con perspectiva teórica de extensión crítica y de modelización empleando las ecuaciones contenidas en la teoría, guías y documentos utilizados como fuentes primarias y secundarias. Como resultado de esta investigación se estimó que el potencial energético del estiércol bovino del país es de 57,393.89 MWh por día o 46.37 TCal/día, dicho potencial fue estimado a partir del cálculo de más de 9 millones de metros cúbicos de biogás por día que generan las más de 186 mil toneladas de estiércol que el hato ganadero del país genera a diario.
A DESESCOLARIZAÇÃO DA SOCIEDADE PARA A CONSTRUÇÃO DO CONHECIMENTO
Authors: PACHIONI Miguel Sgarbi 
Published: December 2023

O presente texto apresenta a resenha do livro "Sociedade sem escolas", do polímata pensador austríaco Ivan Illich. Nesta obra, publicada originalmente em 1971, o modelo de disciplina escolar universal, amplamente adotado no ocidente, é confrontado com a possibilidade de se desescolarizar as instituições e o modelo de aprendizagem para que, assim, tenha-se a possibilidade de compactuar a verdadeira potencialidade criativa dos educandos com suas habilidades. Com isso, fica evidente a razão pelo qual o autor estrutura seu pensamento em direção a natureza da aprendizagem, para quem educar não é escolarizar e não se faz para todos, mas sim por todos.
Credo quia rationale. Kant sobre a Fé Moral
Authors: Zöller Günter 
Published: December 2023

O texto discute a relação sistemática entre fé e razão em Kant, com base na fundamentação e limitação da fé moral no Cãnone da razão pura da Crítica da razão pura. A primeira parte expõe o propósito amplo da Crítica da razão pura aquém da sua limitação a uma "crítica da razão pura meramente especulativa". A segunda parte trata da relação recíproca entre a crítica do saber e a crítica da fé em Kant. A terceira parte define a interação complexa entre momentos teóricos e práticos na questão crítica de Kant referente ao que é lícito esperar ao agente moral em vista do êxito de sua ação. A quarta parte investiga o lugar da fé em Kant perante os modos epistêmicos da opinião e do saber e define o status especial da fé moral. O foco da análise textual e objetiva está na relação complementar entre a limitação crítica do saber teórico em favor da fé moral e da limitação crítica da fé religiosa por meio da consciência moral em Kant.
MUSEUM COMPLEX “FRIEDLAND GATE”: HISTORY OF 20 YEARS OF MUSEUM IFICATION OF FORTIFICATIONS
Authors: Вертяшкина Анастасия Валентиновна , Ярцев Андрей Анатольевич 
Published: December 2023

Статья посвящена процессу музеефикации Фридландских ворот Кенигсбергской крепости. Задачей любой музеефикации является установление, раскрытие и сохранение исторической, научной, культурной, воспитательной, художественной, эстетической значимости объекта. За 20 лет прошедших с момента придания Фридландским воротам статуса музея было решено множество проблем. При этом в его состав были включены близлежащие крепостные постройки, что позволило увеличить объем экспозиционного пространства и рабочей территории. На сегодняшний день комплекс представляет ценность и как памятник фортификационного искусства и как пример реконструкции и приспособления к современным потребностям. Бывший некогда фортификационным объект стал служить мирным целям.
The article is devoted to the process of museumification of the Friedland Gate of the Königsberg Fortress. The task of any museumification is to establish, disclose and preserve the historical, scientific, cultural, educational, artistic, aesthetic significance of the object. In the 20 years that have passed since the Friedland Gate was given the status of a museum, many problems have been solved. At the same time, nearby fortifications were included in its composition, which made it possible to increase the volume of the exposition space and working area. Today, the complex is of value both as a monument of fortification art and as an example of reconstruction and adaptation to modern needs. The once for- tified object began to serve peaceful purposes.
RUSSIAN-BELARUSIAN BORDERLAND IN THE SECOND HALF OF THE 19TH CENTURY: ETHNIC AND CONFESSIONAL ASPECTS (ON THE EXAMPLE OF THE SMOLENSK PROVINCE)
Authors: Гавриленков Алексей Федорович 
Published: December 2023

В статье на основе большого по объему архивного материала автор показывает, как происходило взаимодействие культур великорусского и белорусского этноса в Смоленской губернии во второй половине XIX в. Основами на которой оно развивалось были господство православной веры на данной территории и общность языковых корней. По сути, здесь происходил процесс сближения великорусского и белорусского элементов в рамках формирования русского этноса.
In the article, based on a large amount of archival material, the author shows how the cultures of the Great Russian and Belarusian ethnic groups interacted in the Smolensk province in the second half of the 19th century. The foundations on which it developed were the dominance of the Orthodox faith in a given territory and the commonality of linguistic roots. In fact, there was a process of convergence of the Great Russian and Belarusian elements within the framework of the formation of the Russian ethnos.
SECRETS AND DUNGEONS OF THE NIZHNYNOVGOROD KREMLIN:THE SPECIFICS OF PROMOTING THE FORTIFICATION HERITAGE
Authors: Черкасова Алина Юрьевна 
Published: December 2023

В статье рассказывается о разработке и реализации культурно-просветительской программы в формате квеста «Тайны и подземелья Нижегородского кремля». Описывается её концепция и перспективы развития данной тематики в просветительской деятельности музея. Особое внимание уделено специфике работы по указанной программе с детьми и молодежью.
The article describes the development and implementation of a cultural and educational program in the format of the quest “Secrets and Dungeons of the Nizhny Novgorod Kremlin”. Its concept and prospects for the development of this topic in the educational activities of the museum are described. Particular attention is paid to the specifics of work on this program with children and youth.
Educación Superior remota por emergencia sanitaria: competencias digitales y motivación educativa en estudiantes de psicología - Lima, 2022 R
Authors: Conrado Bello Diana Marcela 
Published: December 2023

Introducción: Las TIC han transformado la educación, siendo la pandemia del 2020 un catalizador crucial que aceleró su adopción global, intensificando su impacto en la experiencia educativa.
Desarrollo: Los educadores deben poseer competencias digitales, incluyendo el manejo de aulas virtuales y herramientas en línea, para asegurar el rendimiento académico y la preparación efectiva de los estudiantes para el mercado laboral, priorizando la motivación intrínseca en el proceso educativo.
Metodología: Este estudio se centra en la interacción entre competencias digitales y motivación educativa en estudiantes universitarios de psicología en Lima Metropolitana durante el año 2022, con el objetivo de avanzar en la comprensión teórica de esta convergencia y su impacto en la dinámica educativa.
Conclusiones: Los resultados de la investigación muestran una correlación estadísticamente significativa (p < 0.05) entre competencias digitales y motivación educativa, respaldando la hipótesis alterna y rechazando la nula.
Impacto de la Microbiota Vaginal en la Salud Reproductiva de la Mujer
Authors: Millán Julio Alejandro Eduardo , Guaman Leon Karina Eliseth , Pagalo Paca Joel David , Bonilla Salinas Kevin David , Tapia Mena David Sebastian , Rueda Hernández Bryan Adrián , Alcívar Reyes María del Carmen 
Published: December 2023

Introducción: La vaginosis bacteriana es un trastorno frecuente de la flora vaginal en mujeres de edad reproductiva, caracterizado por presencia de secreción grisácea maloliente, debido a la disminución de lactobacilos, incremento del ph vaginal y presencia de bacterias anaerobias. Se estima que aproximadamente el 30 % de las mujeres entre 14-49 años presentan vaginosis bacteriana

Desarrollo: El desarrollo aborda los antecedentes y evolución del microbiota vaginal en la salud reproductiva de la mujer, las diferentes infecciones sexuales Concluyendo con las Aplicaciones prácticas o futuras líneas de investigación con respecto a la temática abordada en el artículo.

Conclusiones: La microbiota vaginal juega un papel decisivo en la salud femenina, ya que su equilibrio adecuado está asociado con el mantenimiento de un estado de salud óptimo en el sistema reproductivo. La presencia de una microbiota vaginal diversa y dominada por lactobacilos se ha relacionado con un menor riesgo de infecciones vaginales y enfermedades ginecológicas
Sulfato de magnesio como coadyuvante en la analgesia postoperatoria de pacientes sometidos a procedimientos maxilofaciales
Authors: Saavedra Rios Lorena Marcela , Amaro Sartorio María Victoria 
Published: December 2023

Introducción: En la cirugía maxilofacial, el dolor postoperatorio constituye un problema común en los pacientes, el Sulfato de Magnesio es conocido por su poder analgésico debido a sus efectos como bloqueador de los canales del calcio y antagonista del receptorN- metil-D-aspartato, el cual juega un papel importante en el desarrollo del dolor. Objetivo: Evaluar el efecto analgésico del sulfato de magnesio intravenoso en pacientes sometidos a procedimientos maxilofaciales bajo sedación endovenosa en el servicio de odontología de la sede ambulatoria del Centro Médico Docente La Trinidad. Materiales y Métodos: Estudio experimental: tipo ensayo clínico, (doble ciego). Muestra: 40 pacientes divididos de manera aleatoria en dos grupos de 20 pacientes cada uno, el grupo #1 estuvo conformado por los pacientes que recibieron sulfato de magnesio a dosis de 30mg/kg más la pre medicación habitual, el grupo #2 estuvo conformado por los pacientes que solo recibieron la pre medicación establecida en el protocolo más infusión de solución NaCl 09%, Resultados: Al comparar el dolor postoperatorio mediante la EVA se evidenció un control del dolor en ambos grupos, sin embargo el mayor número de casos que reporto EVA con ausencia de dolor y poco dolor se observó en el grupo tratado con sulfato de magnesio. Conclusiones: La administración de sulfato de magnesio intravenoso a dosis de 30 mg/kg, disminuye la intensidad del dolor postoperatorio comparada con el grupo control en pacientes sometidos a procedimientos maxilofaciales bajo sedación endovenosa en el servicio de odontología de la sede ambulatoria del Centro Médico Docente La Trinidad.
Tratamiento endoscópico de ligadura de hemorroides internas con banda elástica
Authors: Curbata Velásquez Estyvales Yenny , Bandres Dervis 
Published: December 2023

Las hemorroides es una de las enfermedades más comunes de la región anorrectal. Objetivo: Determinar la efectividad del tratamiento endoscópico de ligadura de hemorroides internas con banda elástica. Métodos: Se realizó un estudio retrospectivo, observacional, descriptivo de series de casos, de corte transversal en una muestra conformada por los pacientes con enfermedad hemorroidal tratados endoscópicamente con banda elástica en el servicio de gastroenterología, Centro Médico Docente la Trinidad, enero 2002 a diciembre de 2022. Resultados: Se evaluaron un total de 10 pacientes cuya edad promedio fue de 63,5 ± 11,9 años, el 80,0% era del sexo masculino, el síntoma principal fue el sangrado en el 90,0% de los casos. Las complicaciones inmediatas fue de dolor en una paciente femenina, lo que representa el (50%) de las femeninas estudiadas, siendo evidente el alto número de los casos del sexo masculino (100%) que no presentaron ninguna complicación. Las complicaciones mediatas, se encontraron 3 casos hombres, de los cuales 2 (25,0%) presentaron sangrado y uno (12,5%) prurito, en las mujeres no se reportaron casos. En el seguimiento, la evolución de los pacientes fue satisfactoria cuyo rango fue amplio de 2 meses hasta 20 años después de tratada la enfermedad hemorroidal, el 80,0% se encontraban asintomáticos al momento de la evaluación control y sólo 20,0% afirmó tener mejoría. Conclusión: La ligadura endoscópica proporciona un alto grado de control de los síntomas, comodidad para la aplicación demostrando ser factible, seguro y efectivo para el tratamiento de la enfermedad hemorroidal.