bluuebunny/crossref_metadata_2025_split huggingface dataset:
Metal Ion‐Induced Large Fragment Deactivation: A Different Strategy for Site‐Selectivity in a Complex Molecule
Authors: Ruskin Jonah , Sachs Roseann K. , Wang Muyuan , Dekeyser Roxanne , Lew Zachary , Williams Phoebe , Hwang Habin , Majumdar Ananya , Dudding Travis , Lectka Thomas 
Published: December 2023

AbstractComplex natural product functionalizations generally involve the use of highly engineered reagents, catalysts, or enzymes to react exclusively at a desired site through lowering of a select transition state energy. In this communication, we report a new, complementary strategy in which all transition states representing undesirable sites in a complex ionophore substrate are simultaneously energetically increased through the chelation of a metal ion to the large fragment we wish to neutralize. In the case of an electrophilic, radical based fluorination reaction, charge repulsion (electric field effects), induced steric effects, and electron withdrawal provide the necessary deactivation and proof of principle to afford a highly desirable natural product derivative. We envisage that many other electrophilic or charge based synthetic methods may be amenable to this approach as well.
Origin of an intermediate peak in DMTA analysis of multilayer ABS/PC samples
Authors: Alkhuder Aboubaker , Caro Anne‐Sophie , Gervais Matthieu , Guinault Alain , Ienny Patrick , Perrin Didier , Sollogoub Cyrille 
Published: December 2023

AbstractThree layers film shaped by thermocompression of acrylonitrile butadiene styrene copolymer and polycarbonate have been analyzed in dynamic mechanical thermal analysis in tensile mode. They present two peaks as the film is loaded perpendicularly to the layers and three peaks as the film is loaded in parallel to the layers. Numerical computations confirm that the origin of this peak is not related to a mechanical issue such as the transmission of the imposed deformation from one layer to the other. Using this method, it is demonstrated that this third peak can only be obtained assuming a material transition with its own behavior between layers. Tan δ measurements provide a simple and useful experimental tool to understand more about the interfacial zone in polymer blends.
Preparation and application of high sound insulation polyurethane composite film through glass fiber reinforcement
Authors: Liu Hongyan , Zhan Siqi , Bo Yanyan , Ding Wenhe , Yuan Ruize , Yu Zaiqian , Zhang Yuting , Sun Yuetong , Yu Longjiao , Wang Shiwei , Zhang Mingyao 
Published: December 2023

AbstractLaminated glasses have been widely used in buildings, physical protections, and vehicles because of their safety, sound insulation, thermal insulation, and other performance. In recent years, the high sound insulation performance of laminated glass intermediate films in the frequency range of low or high frequencies has attracted more and more attentions. In this work, a glass fiber/polyurethane elastomer composite (PU‐MGF) film with high transparency and impact resistance has been successfully synthesized, 5 dB of the transmission loss increased at 1600–6000 Hz, and 3.6 dB increased at 63–1600 Hz compared with the control polyurethane film. This is a significant progress in the laminated glass industry. In addition, the transmittance of the composite reaches over 75%. The excellent impact resistance of the laminated glass, based on PU‐MGF film, has been confirmed through falling ball impact test, demonstrating its ability to withstand multiple impacts without spattering. The PU‐MGF film prepared in this work exhibits great potential for applications in building windows, transportation, and soundproof devices.
Poly‐Refractory Rheumatoid Arthritis: An Uncommon Subset of Difficult to Treat Disease With Distinct Inflammatory and Noninflammatory Phenotypes
Authors: David Paula , Di Matteo Andrea , Hen Or , Dass Shouvik , Marzo‐Ortega Helena , Wakefield Richard J. , Bissell Leslie‐Anne , Nam Jacqueline , Mankia Kulveer , Emery Paul , Saleem Benazir , McGonagle Dennis 
Published: December 2023

ObjectiveTo investigate the prevalence of poly‐refractory rheumatoid arthritis (RA) defined as failure of all biological (b)/targeted synthetic (ts)‐disease‐modifying drugs (DMARDs). To further investigate whether patients with persistent inflammatory refractory RA (PIRRA) and noninflammatory refractory RA (NIRRA), determined by objective ultrasound (US) synovitis, have distinct clinical phenotypes in both EULAR difficult‐to‐treat RA (D2T‐RA) and poly‐refractory RA groups.MethodsA cross‐sectional study of 1,591 patients with RA on b/tsDMARDs that evaluated D2T‐RA criteria and subclassified as poly‐refractory if inefficacy/toxicity to at least one drug of all classes. PIRRA was defined if US synovitis in one or more swollen joint and NIRRA if absent. Univariate tests and multivariate logistic regression were conducted to investigate factors associated with poly‐refractory, PIRRA, and NIRRA phenotypes.Results122 of 1,591 were excluded due to missing data. 247 of 1,469 (16.8%) had D2T‐RA and only 40 of 1,469 (2.7%) poly‐refractory RA. This latter group had higher disease activity score 28 C‐reactive protein (CRP) (median 5.4 vs 5.02, P < 0.05), CRP levels (median 13 vs 5 mg/l, P < 0.01), and smoking (ever) rates (20% vs 4%, P < 0.01) compared with other D2T patients. Smoking was associated with poly‐refractory RA (odds ratio 5.067, 95% CI 1.774–14.472, P = 0.002). Of 107 patients with D2T‐RA with recent US, 61 (57%) were PIRRA and 46 (43%), NIRRA. Patients with NIRRA had elevated body mass index (median 30 vs 26, P < 0.001) and higher fibromyalgia prevalence (15% vs 3%, P < 0.05), lower swollen joint count (median: 2 vs 5, P < 0.001), and lower CRP levels (5 vs 10, P < 0.01).ConclusionOnly 2.7% of D2T‐RA failed all classes of b/tsDMARDs. Among D2T‐RA, less than 60% had objective signs of inflammation, representing a target for innovative strategies.image
Inhibition of biofilm, quorum‐sensing, and swarming motility in pathogenic bacteria by magnetite, manganese ferrite, and nickel ferrite nanoparticles
Authors: Doğaç Yasemin İspirli , Tamfu Alfred Ngenge , Bozkurt Selahattin , Kayhan Mehmet , Teke Mustafa , Ceylan Ozgur 
Published: December 2023

AbstractResistance to antibiotics by pathogenic bacteria constitutes a health burden and nanoparticles (NPs) are being developed as alternative and multipurpose antimicrobial substances. Magnetite (Fe3O4 np), manganese ferrite (MnFe2O4 np) and nickel ferrite (NiFe3O4 np) NPs were synthesized and characterized using thermogravimetric analysis, transmission electron microscopy, Fourier transformed infra‐red, and X‐ray diffraction. The minimal inhibitory concentrations (MIC) ranged from 0.625 to 10 mg/mL against gram‐positive (Staphylococcus aureus ATCC 25923 and Enterococcus faecalis ATCC 29212), gram‐negative (Escherichia coli ATCC 25922 and Pseudomonas aeruginosa ATCC 27853) and candida (Candida albicans ATCC 10239 and Candida tropicalis ATCC 13803) species. The NPs exhibited violacein inhibition against Chromobacterium violaceum CV12472 of 100% at MIC and reduced to 27.2% ± 0.8% for magnetite NPs, 12.7% ± 0.3% for manganese ferrite NPs and 43.1% ± 0.2% for nickel ferrite NPs at MIC/4. Quorum‐sensing (QS) inhibition zones against C. violaceum CV026 were 12.5 ±0.6 mm for Fe3O4 np, 09.1 ± 0.5 mm for MnFe3O4 NP and 17.0 ± 1.2 mm for NiFe3O4 np. The NPs inhibited swarming motility against P. aeruginosa PA01 and biofilm against six pathogens and the gram‐positive biofilms were more susceptible than the gram‐negative ones. The NiFe2O4 np had highest antibiofilm activity against gram‐positive and gram‐negative bacteria as well as highest QS inhibition while Fe3O4 NP had highest biofilm inhibition against candida species. The synthesized magnetic NPs can be used in developing anti‐virulence drugs which reduce pathogenicity of bacteria as well as resistance.
Towards understanding how bisphosphonate‐dependent alterations to nutrient canal integrity can contribute to risk for atypical femoral fractures: Biomechanical considerations and potential relationship to a real‐world analogy
Authors: Hart David A. 
Published: December 2023

AbstractBisphosphonates are a class of drugs which have shown good efficacy in the treatment of post‐menopausal osteoporosis, as well as a good safety profile. However, side‐effects such as risk for atypical femoral fractures (AFF) have appeared, leading to a decline in use of the drugs by many patients who would benefit from the treatment. While patient characteristics have contributed to improved understanding of risk factors, the mechanisms involved that explain AFF risk have not appeared. Recently, the possibility that the mechanism(s) involved drug‐induced modification of cells of the nutrient canals of the femur and subsequent compromise in the bone matrix has been published. The present Hypothesis article builds on the concept presented earlier and expands into biomechanical considerations. An analogy of the mechanisms involved to a real‐life scenario is also presented. While this analogy has limitations, consideration of the biomechanical implications of progressive alterations to defects presented by compromised nutrient canal‐bone matrix also presents potential relationships with AFF risk.
Effects of home‐cage elevation on behavioral tests in mice
Authors: Ueno Hiroshi , Takahashi Yu , Murakami Shinji , Wani Kenta , Matsumoto Yosuke , Okamoto Motoi , Ishihara Takeshi 
Published: December 2023

AbstractBackgroundResearch reproducibility is a common problem in preclinical behavioral science. Mice are an important animal model for studying human behavioral disorders. Experimenters, processing methods, and rearing environments are the main causes of data variability in behavioral neuroscience. It is likely that mice adapt their behavior according to the environment outside the breeding cage. We speculated that mice housed on elevated shelves and mice housed on low shelves might have differently altered anxiety‐like behavior toward heights.PurposeThe purpose of this study was to investigate potential behavioral changes in mice raised at different heights for 3 weeks. Changes in behavior were examined using various experimental tests.ResultsMice housed on elevated shelves showed reduced anxiety‐like behavior in a light/dark traffic test compared with mice housed on low shelves. There were no significant differences between the two groups in terms of activity, exploratory behavior, muscle strength, or depression‐like behavior.ConclusionsOur results indicate that different cage heights and corresponding light exposure may alter the anxiety‐like behavior of mice in response to brightness. Researchers need to carefully control the cage height and light intensity experienced by the mice to produce reproducible test results.
Board competence and green innovation—Does external governance matter?
Authors: Yousaf Umair Bin , Tauni Muhammad Zubair , Yousaf Imran , Su Nancy Lixin 
Published: December 2023

AbstractPrevious research examining the link between board attributes and ecological strategies such as green innovation has primarily focused on structural board attributes, yielding mixed findings. Moreover, the critical contextual grounds that shape the relationship between board attributes and green innovation have often been overlooked, leading to potential biases in empirical investigations. Considering that competence drives outstanding performance, we developed a unique measure of board competence that represents the board's intrinsic ability to perform in corporate strategies. Drawing on a holistic perspective of agency, resource dependence, and stakeholder theories, we posit a strong relationship between board competence and green innovation. Furthermore, we contend that this association is moderated by external governance mechanisms, namely audit quality, media coverage, and imitative pressure. Through our analysis of publicly traded Chinese companies, we found compelling evidence to support our assertions. These findings have important implications for policymakers, practitioners, and managers.
Efficacy of catheter‐based drug delivery in a hybrid in vitro model of cardiac microvascular obstruction with porcine microthrombi
Authors: Rösch Yannick , Stolte Thorald , Weisskopf Miriam , Frey Sabrina , Schwartz Rob , Cesarovic Nikola , Obrist Dominik 
Published: December 2023

AbstractMicrovascular obstruction (MVO) often occurs in ST‐elevation myocardial infarction (STEMI) patients after percutaneous coronary intervention (PCI). Diagnosis and treatment of MVO lack appropriate and established procedures. This study focused on two major points by using an in vitro multiscale flow model, which comprised an aortic root model with physiological blood flow and a microfluidic model of the microcirculation with vessel diameters down to 50 μm. First, the influence of porcine microthrombi (MT), injected into the fluidic microchip, on perfusion was investigated. We found that only of all injected MT were fully occlusive. Second, it could also be shown that the maximal concentration of a dye (representing therapeutic agent) during intracoronary infusion could be increased on average by , when proximally occluding the coronary artery by a balloon during drug infusion. The obtained results and insights enhance the understanding of perfusion in MVO‐affected microcirculation and could lead to improved treatment methods for MVO patients.
Retrospective longitudinal assessment of optic nerve sheath diameter in patients with malignant glioma
Authors: Feucht Daniel , Kerscher Susanne R. , Ruff Christer , Schuhmann Martin U. , Roder Constantin , Zipfel Julian 
Published: December 2023

AbstractIntroductionGlioblastoma (GBM) is a tumor with rapid growth and a possible relationship to elevated intracranial pressure (ICP). High ICP may not always be associated with clinical signs. A non‐invasive technique for assessment of ICP is measuring the optic nerve sheath diameter (ONSD). Identifying patients who need immediate intervention is of importance in neuro‐oncological care. The goal of this study is to assess the available magnetic resonance imaging (MRI) of patients with GBM with respect to pre‐ and postoperative ONSD.Methods and MaterialsRetrospective data analysis was performed on all patients operated for GBM at a tertiary care center between 2010 and 2020. Two pre and one postoperative MRI had to be available. Clinical data and ONSD at multiple time points were analyzed and correlated, as well as preoperative volumetrics.ResultsSixty‐seven patients met the inclusion criteria. Clinical signs of elevated ICP were seen in 25.4% (n = 17), while significant perifocal edema was present in 67.2% (n = 45) of patients. Clinical signs of preoperatively elevated ICP were associated with significantly elevated ONSD at diagnosis (p < 0.001) as well as preoperative tumor volume (p < 0.001). Significant perifocal edema at the time of diagnosis was associated with elevated ONSD (p = 0.029) and higher tumor volume (p = 0.003). In patients with significant edema, ONSD increased significantly between preoperative MRIs (p = 0.003/005). In patients with clinical signs of raised ICP, ONSD also increased, whereas it was stable in asymptomatic patients (yes: 5.01+/−4.17 to 5.83+/−0.55 mm, p = 0.010, no: 5.17+/−0.46 mm to 5.38+/−0.41 mm, p = 0.81). A significant increase of ONSD from diagnosis to preoperative MRI and a significant decrease until 3 months postoperatively were observed (p < 0.001).ConclusionsONSD might help identify high ICP in patients with GBM. In this first‐of‐its kind study, we observed a significant increase of ONSD preoperatively, likely associated with edema. Postoperatively, ONSD decreased significantly until 3 months after surgery and increased again at 12 months. Further prospective data collection is warranted.
Hydrogels Loaded with Atorvastatin‐Metal Organic Framework Have a Preventive Effect on Coronary Heart Disease
Authors: Bai Xinghua , Jiang Jun , Tu Sijia , Zhang Weizong 
Published: December 2023

AbstractIn the research, a new three‐dimensional coordination polymer was synthesized by solvothermal method based on the metal ligand LCu=[Cu(2,4‐pydca)2]2− (2,4‐pydca=pyridine‐2,4‐dicarboxylate) and alkaline‐earth ion CaII with chemical composition {[Ca(H2O)2][LCu]⋅DMSO ⋅ 2H2O}n (1) (DMSO=dimethyl sulfoxide). The complex 1 was characterized soundly by Fourier transform infrared (FT‐IR) spectroscopy, elemental analysis (EA), single‐crystal X‐ray diffraction (SCXRD) and thermogravimetric analysis (TGA). Using atorvastatin as drug model, carboxymethyl chitosan and calcium alginate as raw materials, a new type of metal gel particles was prepared. The microstructure of the gel was observed by scanning Electron Microscope (SEM) and its modulation effect on the activity of human cardiomyocytes was evaluated. The results show that the gel particles presented a three‐dimensional porous structure and were able to significantly up‐regulate the cell activity of human cardiomyocytes, which is expected to develop the metal gel particles into drugs for the treatment of coronary heart disease.
Cnidium officinale Makino: Phytology, Phytochemistry, Toxicology, Pharmacology and Prescriptions (1967–2023)
Authors: Ma Jiahui , Liu Wei , Wang Xueyu , Lu Chang , Hao Zezhuang , Wang Ye , Ding Yuling , Li Yong 
Published: December 2023

AbstractCnidium officinale Makino (COM), a perennial herbaceous plant in the Apiaceous family, widely distribute in Eastern Asia and Asia‐Temperate. It has a long history application as a traditional medicine for invigorating the blood and removing blood stasis, and also has been employed to diet, pesticide, herbal bathing materials, the cosmetic and skin care industry. However, there has been no associated review of literature in the past half a century (1967–2023). By searching the international authoritative databases and collecting 229 literatures closely related to COM, herewith a comprehensive and systematic review was conducted. The phytology includes plant distribution and botanical characteristics. The phytochemistry covers 8 major categories, 208 compounds in total, and the quantitative determination of 14 monomer compounds, total polyphenols and total flavonoids. The clinical trial in pregnant women and toxic experiments in mice, the pharmacology of 7 aspects and 82 frequently used prescriptions are summarized. It is expected that this paper will provide forward‐looking scientific thinking and literature support for the further modern research, development and utilization of COM.
Promiscuity of Omphalotin A Biosynthetic Enzymes Allows de novo Production of Non‐Natural Multiply Backbone N‐Methylated Peptide Macrocycles in Yeast
Authors: Matabaro Emmanuel , Witte Luca , Gherlone Fabio , Vogt Eva , Kaspar Hannelore , Künzler Markus 
Published: December 2023

AbstractMultiple backbone N‐methylation and macrocyclization improve the proteolytic stability and oral availability of therapeutic peptides. Chemical synthesis of such peptides is challenging, in particular for the generation of peptide libraries for screening purposes. Enzymatic backbone N‐methylation and macrocyclization occur as part of both non‐ribosomal and ribosomal peptide biosynthesis, exemplified by the fungal natural products cyclosporin A and omphalotin A, respectively. Omphalotin A, a 9fold backbone N‐methylated dodecamer isolated from the agaricomycete Omphalotus olearius, can be produced in Pichia pastoris by coexpression of the ophMA and ophP genes coding for the peptide precursor protein harbouring an autocatalytic peptide α‐N‐methyltransferase domain, and a peptide macrocyclase, respectively. Since both OphMA and OphP were previously shown to be relatively promiscuous in terms of peptide substrates, we expressed mutant versions of ophMA, encoding OphMA variants with altered core peptide sequences, along with wildtype ophP and assessed the production of the respective peptide macrocycles by the platform by high‐performance liquid chromatography, coupled with tandem mass spectrometry (HPLC–MS/MS). Our results demonstrate the successful production of fifteen non‐natural omphalotin‐derived macrocycles, containing polar, aromatic and charged residues, and, thus, suggest that the system may be used as biotechnological platform to generate libraries of non‐natural multiply backbone N‐methylated peptide macrocycles.
The Influence of Melting on Catalysis in Propane Oxidation
Authors: Erdem Ezgi , Tarasov Andrey V. , Kube Pierre , Koch Gregor , Plodinec Milivoj , Lunkenbein Thomas , Carey Spencer , Wang Yuanqing , Hävecker Michael , Rosowski Frank , Schlögl Robert , Trunschke Annette 
Published: December 2023

AbstractA model catalyst composed of crystalline potassium pentavanadate (K3V5O14) supported on silica was studied to elucidate the effect of phase transitions on the performance of potassium‐promoted vanadia catalysts in propane oxidation. Operando calorimetry shows a clear correlation between a drop in activity and an increase in selectivity to propylene upon melting of the crystalline K3V5O14 phase under reaction conditions. The pentavanadate phase itself is not active in propane oxidation, neither in the solid nor in the molten state. The activity of the catalyst mainly originates from highly‐active, i. e., unselective VxOy surface species anchored to silica and formed during synthesis in addition to the supported pentavanadate phase. Melting of K3V5O14 leads to the coverage of these VxOy species preventing the overoxidation of propylene and leading to an increase in propylene selectivity. The change in catalyst properties is therefore due to a physical effect and not to a change in the chemical properties of the predominant crystalline phase.
Targeting the Antifungal Activity of Carbon Dots against Candida albicans Biofilm Formation by Tailoring Their Surface Functional Groups
Authors: Sturabotti Elisa , Camilli Alessandro , Georgian Moldoveanu Vyali , Bonincontro Graziana , Simonetti Giovanna , Valletta Alessio , Serangeli Ilaria , Miranda Elena , Amato Francesco , Giacomo Marrani Andrea , Migneco Luisa Maria , Sennato Simona , Simonis Beatrice , Vetica Fabrizio , Leonelli Francesca 
Published: December 2023

AbstractCarbon dots (CDs) are an emerging class of carbon nanoparticles, which for their characteristics have found applications in many fields such as catalysis, materials and biomedicine. Within this context, the application of CDs as antibacterial agents has received much attention in very recent years, while their use as antifungal nanoparticles has been scarcely investigated. Here we report a systematic investigation of the surface functional groups of CDs to study their influence on these nanoparticles’ against Candida albicans. Three classes of CDs have been synthesised and fully characterized. A thorough in vitro and in vivo biological screening against C. albicans was performed to test their antifungal, antiadhesion and antibiofilm formation activities. Moreover, the interaction with C. albicans cells was investigated by microscopic analysis. Our results evidence how the presence of a positively polarised surface results crucial for the internalization into COS‐7 cells. Positively charged nanoparticles were also able to inhibit adhesion and biofilm formation, to interact with the cellular membrane of C. albicans, and to increase the survival of G. mellonella infected larvae after the injection with positive nanoparticles. The antifungal activity of CDs and their extremely low toxicity may represent a new strategy to combat infections sustained by C.albicans.
Sichere Sanierung von Tanklagern
Authors: Gieseler Jens 
Published: December 2023

AbstractUnternehmen, die große Tanks vorhalten, müssen diese Anlagen alle zehn Jahre sanieren und auf den neusten technischen Stand bringen. Jeder Tank ist anders und mit vielen Besonderheiten ausgestattet. Sicherheit, Arbeits‐ und Umweltschutz haben im Gerüstbau für die Sanierung höchste Prioriät, was bei Gemeinhardt Service mit dem SCCP‐Zertifikat belegt wird.