bluuebunny/crossref_metadata_2025_split huggingface dataset:
Revisão narrativa do uso de simulação realística de baixa fidelidade para o ensino da avaliação da dilatação do colo uterino
Authors: De Souza Rodrigo Rocha , Ferreira Helen Campos 
Published: February 2024

A aquisição de competência para a avaliação da caracterização do colo uterino no trabalho de parto e sua evolução para o parto, torna-se imprescindível porque através desta a tomada de decisão e a conduta profissional assegurará o bem estar da mãe, feto ou bebê. Contudo, observa-se uma defasagem relativa ao uso de simulador para o ensino desta habilidade fragilizando a translação de conhecimentos. Neste sentido, fez-se uma revisão narrativa de artigos científicos nas línguas: Português, Inglês e Espanhol nas bases de dados Portal BVS, SciELO, LILACS e PubMed, de 2017 a 2021, utilizando-se descritores isolados e associados. Após aplicação dos critérios de inclusão e exclusão, detectou-se não haver registro de experiência de simulador de baixa fidelidade acessível que facilite ao aprendiz a aquisição desta habilidade, favorecendo o desenvolvimento de produção técnica para tal fim.
Educação entre pares na prevenção do Vírus da Imunodeficiência Humana em adolescentes: revisão sistemática
Authors: Dos Santos Marina Marisa Palhano , De Oliveira Isabelle Christine Marinho , Feijão Alexsandra Rodrigues 
Published: February 2024

A mudança no perfil etário da epidemia de HIV, crescente em adolescentes, revela uma demanda por estratégias preventivas. Com base no pressuposto de que o grupo social em que o adolescente está inserido exerce uma forte influência na maneira como ele se comporta. a educação entre pares se mostra como uma metodologia possível. Este estudo tem como objetivo descrever e avaliar as evidências científicas sobre a estratégia de Educação entre pares na prevenção do Vírus da Imunodeficiência Humana em adolescentes. Trata-se de uma Revisão sistemática, realizada em 14 fontes de dados entre maio e julho de 2022. Um total de 4855 estudos foram encontrados, foram incluídos 8 artigos. Avaliou-se o grau de concordância entre revisores, o risco de viés e a qualidade e força da recomendação dos desfechos. A amostra final foi composta de 8 estudos. Foi possível elencar um total de seis desfechos, divididos em “Comportamentais” e “Não comportamentais”. O único desfecho comum a todos os estudos foi “Conhecimento sobre HIV”. Conclui-se que as evidências encontradas foram sustentadas por pesquisas de maior rigor metodológico e risco geral de viés baixo, aspecto que ampara a forte recomendação para que a educação entre pares seja adotada como conduta pelos profissionais de saúde e gestores.
The Concept of Integration of Science and Islam in Higher Education Perspective of M. Natsir
Authors: Patahuddin Askar , Hafidhuddin Didin , Indra Hasbi , Handrianto Budi 
Published: February 2024

This research aims to find the concept in Indonesian universities that integration by science and religion in their regulations. The research employs a qualitative method with a historical-philosophical approach, conducting content analysis on the thoughts of M. Natsir to generate a new concept. The research findings indicate, firstly, that the concept of integrating science and Islam in higher education from M. Natsir's perspective involves the integration of Islamic knowledge and general knowledge without secularizing science and Islam. This integration includes mastering foreign languages, particularly Arabic, instilling moral values through ta’dib, enhancing learning through the presentation of arguments, advising, and adopting a wise approach with efforts in higher education to orient graduates towards becoming strong and sincere preachers.
The Influence of Experiential Marketing, Electronic Word of Mouth, and Brand Image on Customer Loyalty for Everwhite Beauty Products
Authors: Situngkir Ober , Nuvriasari Audita 
Published: February 2024

This inquire about points to evaluate the impact of Experiential Marketing, Electronic Word of Mouth, and Brand Image on Client Dependability for Everwhite excellence items. The sampling technique used a questionnaire technique with the number of research samples was 100 respondents. Speculation test comes about demonstrate that Experiential Marketing, Electronic Word of Mouth, and Brand Image have a positive and critical impact on customer loyalty for Everwhite beauty products. These show that the stronger the Experiential Marketing, Electronic Word of Mouth, and Brand Image, the more client dependability for Everwhite beauty products will increase. The comes about of coefficient of assurance (r²) test gotten an r square coefficient (r²) esteem of 0.523, which suggests that Experiential Marketing, Electronic Word of Mouth, and Brand Image contribute to client dependability by 52.3%. Therefore, these there variables together will have a positive and noteworthy impact on client dependability for Everwhite magnificence items.
Gut Microbiota. Neuropolen for Recovery after A Ischemic Stroke
Authors:   Deniplant-Aide Sante Medical Center, Biomedicine, Bucharest, Romania, GIURGIU Gheorghe , COJOCARU Manole ,   Member of Academy of Romanian Scientists, Scientific Researcher degree I
Titu Maiorescu University, Faculty of Medicine, Bucharest, Romania
Published: February 2024

Background The brain possesses an extraordinary ability to heal itself after a stroke. This ability is known as neuroplasticity. The relationship between the gut microbiota and stroke is recent, with early studies dating from 2013. Recent studies support that gut microbiota is associated with ischemic stroke through the gut-brain axis, thereby modulating stroke pathogenesis.	Objectives Gut dysbiosis, defined as alterations to the gut microbial communities has been proposed in stroke. To determine whether Neuropolen can be a potential treatment for recovery after a stroke.	Material and methods The 2-way communication between the gut and the brain, which involves the brain, the gut microbiota, and the intestinal tissue, has been suggested as a key component of stroke outcome. To arrive at these observations, authors examined how Neuropolen and diet solve disabilities.	Results The gut microbiota can increase the risk of a cerebrovascular event, playing a role in the onset of stroke. Conversely, stroke can induce dysbiosis of the gut microbiota. We found that Neuropolen may be important for functional recovery after a stroke. Neuropolen that may help minimize the degree of complications, stimulation enhances plasticity of the brain, in which noninjured parts of the brain can pick up the job of the injured brain areas.	Conclusion In this presentation, authors describe the role of the gut microbiota, microbiome and microbiota-derived metabolites in stroke, and their use as therapeutic targets. Neuropolen may be a potential therapy for recovery after a stroke, it can quickly feed oxygen to the brain and protect brain cells.
The THREE CENTERS OF EDUCATION AS INSTITUTIONS FOR THE DEVELOPMENT OF LEARNING THEORY
Authors: - Al-Muthmainnah 
Published: February 2024

This research is aiming at elaborating the three educational centers which is a concept that gradually and integrated assumes educational responsibility for children. These three centers include education in the family environment, education in the school environment, and education in the community environment. The three centers responsible for education are required to work together comprehensively. This research uses a literature review approach combined with the researcher's reflection method. The literature method utilizes research articles published in various current scientific journals, while the reflection method is based on the knowledge and experience of researchers in recognizing, identifying and responding to student phenomena in various educational institutions. The family environment, which is the first environment and is considered the foundation of a child's education and the beginning of the education that will be pursued later, also plays a major role in personality formation. The school environment is the second environment that children face. Education in the school environment has a foundation, objectives, content, methods and other requirements which are arranged systematically in the form of a curriculum. Therefore, schools are considered the foundation of knowledge. Meanwhile, in society, children will be aware of a number of educational and teaching theories that have been taught in previous educational institutions. Then they will actualize and involve themselves in the community environment.
Keywords: three centers of education, development, learning theory
Analisis Pengaruh Resonansi Merek dan Kepercayaan Merek terhadap Loyalitas Merek Pengguna Produk Kecantikan Somethinc di Surakarta
Authors: Meylda Anan Maulidya  , Sri Murwanti  
Published: February 2024

The purpose of this research is to investigate how trust and brand resonance affect the brand loyalty of users of somethinc beauty products in Surakarta. The target audience of this research is people in the Surakarta area who use Somethinc beauty products. A total of 100 respondents who live in the Surakarta area and are more than 17 years old are the samples used. The result showed that the brand resonance variable had a positive and significant effect on the brand loyalty of Somethinc beauty products users in Surakarta. Brand trust variables have a significant effect on the brand loyalty of Somethinc beauty product users in Surakarta. Brand trust variable has a significant effect on brand loyalty of Somethinc beauty product users in Surakarta. The findings of f2 calculation show that brand resonance and brand loyalty are adequately correlated. Based on the calculation of R2 value, changes in brand loyalty variables can be explained by changes in brand resonance and brand trust variables.
EVALUASI KERASIONALAN PENGGUNAAN OBAT ARV (ANTI RETROVIRAL) PADA PASIEN ODHA (ORANG DENGAN HIV AIDS) DI RUMAH SAKIT UMUM DAERAH KOTA TANGERANG PERIODE OKTOBER – DESEMBER 2022
Authors: Astuti Tri , Panduwiguna Ivans , Nugrahini Lestari 
Published: February 2024

Abstrak
Antiretroviral (ARV) merupakan obat yang digunakan pasien HIV/AIDS untuk mengurangi resiko penularan HIV, menghambat perburukan infeksi oportunistik, menurunkan jumlah virus dalam darah sampai tidak terdeteksi dan meningkatkan kualitas hidup pasien HIV/AIDS. Penelitian ini dilakukan dengan metode deskriptif dengan pengambilan data secara retrospektif dari catatan rekam medis pada bulan Oktober - Desember 2022 di RSUD Kota Tangerang. Obat ARV yang paling banyak digunakan yaitu Triple FDC sebanyak 61 % dimana usia pasien yang paling banyak terkena HIV/AIDS yaitu pasien dengan usia produktif yaitu umur 26 – 45 tahun sebesar 63% dan paling banyak pasien laki-laki dengan jumlah 81%

Kata Kunci :Anti Retroviral, Evaluasi Penggunaan Obat, HIV/AIDS
ANALISIS TEPAT OBAT DAN TEPAT DOSIS PENGGUNAAN OBAT ANTIINFLAMASI NON STEROID (AINS) DI APOTEK INA FARMA PERIODE 2022/2023
Authors: Wika I Gede Wika Gita Septiadi , Nugrahini Lestari , Puspaningrat Luh Putu Desy 
Published: February 2024

Septiadi, Gita, Wika, Gede, I. 2023. Analisis Tepat Obat Dan Tepat Dosis Penggunaan Obat Antiinflamasi Non Steroid (AINS) Di Apotek Ina Farma Periode 2022/2023 . Skripsi Penelitian, Program Studi Ilmu Farmasi, Sekolah Tinggi Ilmu Kesehatan Buleleng. Pembimbing (1) apt. Lestari Nugrahini, S.Farm., M.Farm. Pembimbing (2) Luh Desi Puspaningrat, S.Km.,M,Si

Nyeri merupakan sebuah gangguan kesehatan yang sering dialami oleh masyarakat. Nyeri pada setiap orang berbeda dalam hal skala maupun tingkatannya dan hanya orang itulah yang dapat menjelaskan atau mengevaluasi rasa nyeri yang dialaminya dan penggunaan obat Antiinflamasi Non Steroid (AINS) masih menjadi pilihan utama sebagai terapi farmakologi Adanya efek samping yang bisa terjadi maka perlu ditunjang dengan penggunaan yang rasional khususnya pada fasilitas kesehatan penelitian ini bertujuan untuk menganalisis penggunaan obat antiinflamasi non steroid (AINS). Jenis penelitian ini merupakan penelitian non eksperimental dengan desain deskriptif kuantitatif. Sampel diambil dengan cara total sampling dari populasi yang memenuhi kriteria, inklusi resep periode Januari sampai dengan Maret 2023 dan memiliki data resep insscriptio, invovatio,signatura, subscriptio, pro. Jumlah sampel yang diperoleh yaitu sebesar 44.

Kata kunci : Tepat Dosis dan Tepat Obat, Instalasi Farmasi Apotek
Mild phenotypes in a series of patients with Opitz GBBB syndrome with MID1 mutations
Authors: So Joyce , Suckow Vanessa , Kijas Zofia , Kalscheuer Vera , Moser Bettina , Winter Jennifer , Baars Marieke , Firth Helen , Lunt Peter , Hamel Ben , Meinecke Peter , Moraine Claude , Odent Sylvie , Schinzel Albert , van der Smagt J.J. , Devriendt Koen , Albrecht Beate , Gillessen‐Kaesbach Gabriele , van der Burgt Ineke , Petrij Fred , Faivre Laurence , McGaughran Julie , McKenzie Fiona , Opitz John M. , Cox Timothy , Schweiger Susann 
Published: November 2004

AbstractOpitz syndrome (OS; MIM 145410 and MIM 300000) is a congenital midline malformation syndrome characterized by hypertelorism, hypospadias, cleft lip/palate, laryngotracheoesophageal (LTE) abnormalities, imperforate anus, developmental delay, and cardiac defects. The X‐linked form (XLOS) is caused by mutations in the MID1 gene, which encodes a microtubule‐associated RBCC protein. In this study, phenotypic manifestations of patients with and without MID1 mutations were compared to determine genotype‐phenotype correlations. We detected 10 novel mutations, 5 in familial cases, 2 in sporadic cases, and 3 in families for whom it was not clear if they were familial or sporadic. The genotype and phenotype was compared for these 10 families, clinically diagnosed OS patients found not to have MID1 mutations, and 4 families in whom we have previously reported MID1 mutations. This combined data set includes clinical and mutation data on 70 patients. The XLOS patients with MID1 mutations were less severely affected than patients with MID1 mutations reported in previous studies, particularly in functionally significant neurologic, LTE, anal, and cardiac abnormalities. Minor anomalies were more prevalent in patients with MID1 mutations compared to those without mutations in this study. Female MID1 mutation carriers had milder phenotypes compared to male MID1 mutation carriers, with the most common manifestation being hypertelorism in both sexes. Most of the anomalies found in the patients of the present study do not correlate with the MID1 mutation type, with the possible exception of LTE malformations. This study demonstrates the wide spectrum of severity and manifestations of OS. It also shows that XLOS patients with MID1 mutations may be less severely affected than indicated in prior reports. © 2004 Wiley‐Liss, Inc.
Vision system for on‐line characterization of paper slurry
Authors: Sari‐Sarraf Hamed , Goddard James S. , Abidi Besma R. , Hunt Martin A. 
Published: November 2004

AbstractThis paper presents a detailed description of a vision system that detects and localizes the nonuniformities that appear on the paper slurry (wood fiber and water mixture) at the wet end of a paper machine. Specifically, the system monitors the paper slurry as it exits the headbox and alerts the operators of any event (e.g., streaks) that disrupts the otherwise homogeneous background. These events affect crucial product properties such as formation. A poor formation results in thick and thin spots on the sheet and impacts its strength and printability. This paper describes the vision system in terms of its hardware modules, as well as the image processing algorithms that it utilizes to perform its function. The system acquires intensity and topographic information from the scene. It uses texture‐based features for the detection and facet‐based descriptors for the localization of the nonuniformities. In addition to being tested in a laboratory environment, a prototype of this system was constructed and deployed to a paper mill, where its performance was evaluated under realistic conditions. Installed on a fourdrinier paper machine, running at 480 m/min and producing linerboard material, the vision system monitored about a 1 m wide area and successfully detected and localized slurry streaks. Published 2001 John Wiley & Sons, Inc. Int J Imaging Syst Technol, 11, 231–242, 2000
Instrumental relationships: A potential relational model for inner‐city youth programs
Authors: Halpern Robert 
Published: November 2004

AbstractIn this article, a distinct type of adult–youth relationship found in some youth programs and characterized as instrumental is discussed. Such relationships focus primarily on joint work on a task or project, or in a discipline, with the adult having expertise and a strong identity in the substantive domain involved, rather than in youth work per se. It is hypothesized that, by virtue of their matter‐of‐fact quality, their substantive focus, and their particular interactional patterns, instrumental relationships offer potential for some reworking of adolescents' sense of self. © 2005 Wiley Periodicals, Inc. J Comm Psychol 33: 11–20, 2005.
On urban ground: Understanding African‐American intergenerational partnerships in urban communities
Authors: Ginwright Shawn A. 
Published: November 2004

AbstractFewer job opportunities, rising violence, and failing schools have all shaped the structure of opportunities for both youth and adults in urban communities. However, researchers understand very little about how these factors influence the capacity for adults in urban communities to form meaningful partnerships with youth. First, this article explores how urban environments shape youth–adult partnerships within African‐American communities. Second, the article promotes the idea that adult development is a necessary component of effective intergenerational partnerships in urban communities. Third, the article highlights innovative practices that focus on how to support the development of adults to more effectively partner with young people. © 2005 Wiley Periodicals, Inc. J Comm Psychol 33: 101–110, 2005.
Simulation of the activation of α‐chymotrypsin: Analysis of the pathway and role of the propeptide
Authors: Mátrai Janka , Verheyden Gert , Krüger Peter , Engelborghs Yves 
Published: November 2004

Abstractα‐Chymotrypsin undergoes a reversible conformational change from an inactive chymotrypsinogen‐like structure at high pH to an active conformation at neutral pH. In order to gain insight into this process on a structural level, we applied molecular dynamics and targeted molecular dynamics simulations in aqueous environment on the activation and inactivation processes of three different types of chymotrypsin. These are the wild‐type bovine chymotrypsin containing the propeptide and the bovine and rat chymotrypsin lacking the propeptide. From these simulations, the importance of the propeptide and of the sequence differences between the rat and bovine variants from the viewpoint of activation could be evaluated and compared with previous fluorescence stopped flow results. The obtained results show the unambiguous influence of the propeptide on the explored conformational space, whereas the sequence differences between bovine and rat chymotrypsin play a minor role. The main features of activation are present in both the wild type and the variant lacking the propeptide, despite the fact that different parts of the conformational space were explored. The comparison of all trajectories shows that particular amino acid residues, such as 17, 18, 19, 187, 217, 218, and 223, undergo large dihedral transitions during the activation process, suggesting a role as hinge residues during the conformational change.
Comparative computational analysis of prion proteins reveals two fragments with unusual structural properties and a pattern of increase in hydrophobicity associated with disease‐promoting mutations
Authors: Kuznetsov Igor B. , Rackovsky Shalom 
Published: November 2004

AbstractPrion diseases are a group of neurodegenerative disorders associated with conversion of a normal prion protein, PrPC, into a pathogenic conformation, PrPSc. The PrPSc is thought to promote the conversion of PrPC. The structure and stability of PrPC are well characterized, whereas little is known about the structure of PrPSc, what parts of PrPC undergo conformational transition, or how mutations facilitate this transition. We use a computational knowledge‐based approach to analyze the intrinsic structural propensities of the C‐terminal domain of PrP and gain insights into possible mechanisms of structural conversion. We compare the properties of PrP sequences to those of a PrP paralog, Doppel, and to the distributions of structural propensities observed in known protein structures from the Protein Data Bank. We show that the prion protein contains at least two sequence fragments with highly unusual intrinsic propensities, PrP(114–125) and helix B. No segments with unusual properties were found in Doppel protein, which is topologically identical to PrP but does not undergo structural rearrangements. Known disease‐promoting PrP mutations form a statistically significant cluster in the region comprising helices B and C. Due to their unusual properties, PrP(114–125) and the C terminus of helix B may be considered as primary candidates for sites involved in conformational transition from PrPC to PrPSc. The results of our study also show that most PrP mutations associated with neurodegenerative disorders increase local hydrophobicity. We suggest that the observed increase in hydrophobicity may facilitate PrP‐to‐PrP or/and PrP‐to‐cofactor interactions, and thus promote structural conversion.
Correspondence between anomalous m‐ and Δ Cp‐values in protein folding
Authors: Otzen Daniel E. , Oliveberg Mikael 
Published: November 2004

AbstractProteins folding according to a classical two‐state system characteristically show V‐shaped chevron plots. We have previously interpreted the symmetrically curved chevron plot of the protein U1A as denaturant‐dependent movements in the position of the transition state ensemble (TSE). S6, a structural analog of U1A, shows a classical V‐shaped chevron plot indicative of straightforward two‐state kinetics, but the mutant LA30 has a curved unfolding limb, which is most consistent with TSE mobility. The kinetic m‐values (derivatives of the rate constants with respect to denaturant concentration) in themselves depend on denaturant concentration. To obtain complementary information about putative mobile TSEs, we have carried out a thermodynamic analysis of the three proteins, based on data for refolding and unfolding over the range 10°C to 70°C. The data at all temperatures can be fitted to two‐state model systems. Importantly, for all three proteins the activation heat capacities are, within error, identical to the heat capacities measured in independent experiments under equilibrium conditions. Although the equilibrium heat capacities are essentially invariant with regard to denaturant concentration, the activation heat capacities, similar to the structurally equivalent kinetic m‐values, show marked denaturant dependence. Furthermore, the values of β‡ at different denaturant concentrations measured by m‐values and by heat capacity values are very similar. These observations are consistent with significant transition state movements within the framework of two‐state folding. The basis for TSE movement appears to be enthalpic rather than entropic, suggesting that the binding energy of denaturant–protein interactions is a major determinant of the response of energy landscape contours to changing environments.