bluuebunny/crossref_metadata_2025_split huggingface dataset:
Structural Dynamics of Protein Interactions Using Site-Directed Spin Labeling of Cysteines to Measure Distances and Rotational Dynamics with EPR Spectroscopy
Authors: Roopnarine Osha , Thomas David D. 
Published: October 2023

AbstractHere we review applications of site-directed spin labeling (SDSL) with engineered cysteines in proteins, to study the structural dynamics of muscle and non-muscle proteins, using and developing the electron paramagnetic resonance (EPR) spectroscopic techniques of dipolar EPR, double electron electron resonance (DEER), saturation transfer EPR (STEPR), and orientation measured by EPR. The SDSL technology pioneered by Wayne Hubbell and collaborators has greatly expanded the use of EPR, including the measurement of distances between spin labels covalently attached to proteins and peptides. The Thomas lab and collaborators have applied these techniques to elucidate dynamic interactions in the myosin–actin complex, myosin-binding protein C, calmodulin, ryanodine receptor, phospholamban, utrophin, dystrophin, β-III-spectrin, and Aurora kinase. The ability to design and engineer cysteines in proteins for site-directed covalent labeling has enabled the use of these powerful EPR techniques to measure distances, while showing that they are complementary with optical spectroscopy measurements.
Echocardiographic mechanical dyssynchrony predicts long-term mortality in patients with cardiac resynchronisation therapy
Authors: Ahmed Mohamed Abdelbaset , Gercek Muhammed , Sommer Philipp , Rudolph Volker , Dumitrescu Daniel , Faber Lothar , Fox Henrik 
Published: October 2023

AbstractCardiac resynchronisation therapy (CRT) is an established treatment for patients with symptomatic heart failure with reduced left ventricular ejection fraction (LVEF ≤ 35%; HFrEF) and conduction disturbances (QRS duration ≥ 130 ms). The presence of mechanical dyssynchrony (MD) on echocardiography has been hypothesised to be of predictive value in determining indication for CRT. This study investigated the impact of MD (apical rocking [AR] and septal flash [SF]) on long-term survival in CRT recipients. HFrEF patients (n = 425; mean age 63.0 ± 10.6 years, 72.3% male, 60.7% non-ischaemic aetiology) with a guideline-derived indication for CRT underwent device implantation. MD markers were determined at baseline and after a mean follow-up of 11.5 ± 8.0 months; long-term survival was also determined. AR and/or SF were present in 307 (72.2%) participants at baseline. During post-CRT follow-up, AR and/or SF disappeared in 256 (83.4%) patients. Overall mean survival was 95.9 ± 52.9 months, longer in women than in men (109.1 ± 52.4 vs. 90.9 ± 52.4 months; p < 0.001) and in younger (< 60 years) versus older patients (110.6 ± 53.7 vs. 88.6 ± 51.1 months; p < 0.001). Patients with versus without MD markers at baseline generally survived for longer (106.2 ± 52.0 vs. 68.9 ± 45.4 months; p < 0.001), and survival was best in patients with resolved versus persisting MD (111.6 ± 51.2 vs. 79.7 ± 47.6 months p < 0.001). Age and MD at baseline were strong predictors of long-term survival in HFrEF patients undergoing CRT on multivariate analysis. Novel echocardiography MD parameters in HFrEF CRT recipients predicted long-term mediated better outcome, and survival improved further when AR and/or SF disappear after CRT implantation.

Graphical abstract
Evaluation of the effects of exogenous cortisol manipulation and the glucocorticoid antagonist, RU486, on the exploratory tendency of bluegill sunfish (Lepomis macrochirus)
Authors: Carbajal Annaïs , Lawrence Michael J. , Gilmour Kathleen M. , Lopez-Bejar Manel , Cooke Steven J. 
Published: October 2023

Abstract In teleost fishes, activation of the hypothalamic-pituitary-interrenal axis leads to an elevation of circulating cortisol levels as a primary stress response. While acute elevation of cortisol is generally beneficial, long-term elevation, a common characteristic of chronic stress, may lead to detrimental effects on health and physiological performance in fishes. Some stress-mediated behavioural shifts, such as variation along the shy-boldness axis in fish, may influence individual fitness. The present study evaluated the role of cortisol and its mechanisms of action in the exploratory behaviour of the bluegill sunfish (Lepomis macrochirus). Fish were implanted with cocoa butter alone (sham treatment), or cocoa butter containing cortisol, or cortisol and the glucocorticoid receptor antagonist, RU486. A control (untreated) group was also used. Animals were held for 48 h following treatment and then were subjected to a Z-maze trial to characterize the exploratory behaviour. Cortisol treatment had no measurable effect on the exploratory behaviour of bluegill sunfish. Despite presenting a higher probability of refuge emergence, fish treated with cortisol combined with RU486 behaved similarly to cortisol-treated and control groups. While these results suggest that cortisol may not be involved in the mechanisms controlling boldness, the influence of cortisol elevation across longer time periods plus validation in different contexts will be necessary to confirm this conclusion.
Decolonizing Botany: Indonesia, UNESCO, and the Making of a Global Science
Authors: Goss Andrew 
Published: October 2023

AbstractDecolonization created new opportunities for international scientific research collaboration. In Indonesia this began in the late 1940s, as Indonesian scientists and officials sought to remake the formerly colonial botanical gardens in the city of Bogor into an international research center. Indonesia sponsored the Flora Malesiana project, a flora of all of island Southeast Asia. This project was formally centered in Bogor, Indonesia, with participation from tropical botanists from around the world. The international orientation of Indonesian science led to the establishment of one of UNESCO’s Field Science Co-operation Offices in Jakarta, and to a period of close collaboration between Indonesian botanists and UNESCO. This paper examines the importance of UNESCO’s Humid Tropics research program, which initially provided further opportunities for Indonesian botanists to participate in international scientific networks. The paper concludes by showing that the Humid Tropics program led to the slow erosion of Indonesian agency and authority over tropical botany, and the assertion of Western control and management over tropical botany research.
Stability of Some Anticipating Semilinear Stochastic Differential Equations of Skorohod Type
Authors: León Jorge A. , Márquez-Carreras David , Vives Josep 
Published: October 2023

AbstractIn the present paper, we study different types of stability of the solution of a semi-linear anticipating stochastic differential equation driven by a Brownian motion, with a random variable as initial condition. The involved stochastic integral is the Skorohod one. Being the initial condition random, we need to redefine the stability concepts. The new stability criteria depend on the derivative of the initial condition in the Malliavin calculus sense.
Parent Aggression Exposure and Negative Expectancies in Couple Conversation: Rejection Sensitivity as a Mediator
Authors: Beale Alexis M. , Ryjova Yana , Gold Alaina I. , Kim Yehsong , Kazmierski Kelly F. M. , Daspe Marie-Ève , Lai Mark H. C. , Margolin Gayla 
Published: October 2023

Abstract
Purpose
Exposure to aggression during childhood or adolescence has been linked to negative outcomes, including poor future romantic relationship functioning. As a step toward understanding such intergenerational influences, the present study investigates whether aggression exposure in the family-of-origin is associated with negative expectancies of romantic partner interactions when facing a challenging couple discussion. Rejection sensitivity is tested as a mediator of this association, and gender was explored as a potential moderator.

Method
Negative expectancies were assessed before a 10-minute discussion about desired changes in the relationship in a sample of young adult dating couples. To test the theorized relationship between variables, the study employed self-report measures of parent aggression, rejection sensitivity, and negative expectancies.

Results
Multilevel analyses showed that exposure to family-of-origin aggression was positively associated with negative expectancies about the upcoming change discussion task, even after controlling for dating aggression within the current relationship. Additionally, rejection sensitivity mediated the association between parent aggression and negative expectancies. Gender did not moderate these associations.

Conclusions
Findings suggest that individuals who experience aggression in their family-of-origin are more likely to anticipate negative interactions with their dating partner during young adulthood. Results also highlight rejection sensitivity as a key mechanism of this process. Taken together, these findings help to explain why some individuals have negative expectancies as they approach difficult discussions with a romantic partner, which may be a putative link in the intergenerational continuity of aggression.
A new result on boundedness of the Riesz potential in central Morrey–Orlicz spaces
Authors: Burtseva Evgeniya , Maligranda Lech 
Published: October 2023

AbstractWe improve our results on boundedness of the Riesz potential in the central Morrey–Orlicz spaces and the corresponding weak-type version. We also present two new properties of the central Morrey–Orlicz spaces: nontriviality and inclusion property.
Consequentialism and the Role of Practices in Political Philosophy
Authors: Schmidt Andreas T. 
Published: October 2023

AbstractPolitical philosophers have recently debated what role social practices should play in normative theorising. Should our theories be practice-independent or practice-dependent? That is, can we formulate normative institutional principles independently of real-world practices or are such principles only ever relative to the practices they are meant to govern? Any first-order theory in political philosophy must contend with the methodological challenges coming out of this debate. In this article, I argue that consequentialism has a plausible account of how social practices should factor in normative political philosophy. I outline a version of consequentialism, Practice Consequentialism, that provides a plausible blueprint for integrating social practices in normative theorising. Second, I argue that Practice Consequentialism accounts well for the central arguments on both sides of the practice-dependence debate. Capturing arguments for practice-dependence, consequentialism brings out why real-world practices are central in formulating institutional principles. Conversely, capturing arguments for practice-independence, consequentialism offers a clear external normative perspective from which to evaluate practices.
Reflections on the Principles of Remoteness in Contract in Comparative Law
Authors: Barnett Katy 
Published: October 2023

AbstractThis paper traces the history of remoteness in contract law, namely the legal formants (in Rodolfo Sacco’s terms) constraining the availability of contract damages in various legal systems. Our journey takes us through different times, continents and cultures, from the eighteenth century to the twenty–first century, across the law of France, United States, England and Wales, India and Australia, among other jurisdictions. While it might seem that civilian and common law traditions have very different morphological legal forms, once a closer historical, cultural, and anthropological gaze is turned upon the legal formants involved, it can be seen that remoteness discloses a shared concern which may be common to many human societies and cultures. In other words, as a matter of social experience, humans who enter into transactions generally realise that it is impossible to know the future, or to know what all outcomes of the transaction will be. Consequently, it is recognised that it would be unfair and unjust to hold a defendant liable for all outcomes, and as our journey will show, legal systems seek guidance from other legal systems in their efforts to deal with this problem.
Hormonal regulation of somatic embryogenesis in Medicago spp.
Authors: Kępczyńska Ewa , Kępczyński Jan 
Published: October 2023

AbstractIn contrast to zygotic embryogenesis, somatic embryogenesis culture systems, not limited in tissue quantity and accessibility, were found to be useful models with which to investigate the role of phytohormones during induction, development and maturation of somatic embryos. Artificial seed technology is one of the important efficient methods of in vitro propagation of a number of agronomically important plants, including Medicago species, with Medicago truncatula serving as a Fabaceae experimental model. The review will focus on the role of exogenous and endogenous plant growth regulators /phytohormones in different phases of somatic embryogenesis in Medicago species. There is evidence that induction and development of M. sativa somatic embryos require endogenous levels not only of growth stimulants (e.g. gibberellins, auxins and cytokinins), but also of phytohormones known as growth inhibitors, i.e. ABA, jasmonates and ethylene. Any alterations in the contents of these plant growth inhibitors during the distinct phases of M. sativa SE, proved unfavorable for the subsequent somatic embryo production, suggesting that the level of biosynthetic activity in tissues is optimal for sustaining an appropriate course of this developmental process. It turned out that, in the case of ethylene, its synthesis in and activity towards M. sativa is not linked to the induction, but is very important in the proliferation and differentiation phases. An ABA content lower than that of active GAs (GA4, GA7, GA1, GA5, GA3, GA6) and IAA was proven to enable the embryo formation in the M. truncatula callus. The importance of some phytohormones in the germination and conversion of somatic embryos is also discussed.
Ionic conductivity of the molten systems (LiF–CaF2)eut–NdF3, (LiF–NaF)eut–NdF3, (NaF–CaF2)eut–NdF3 and (LiF–MgF2)eut–NdF3
Authors: Krishnan Dhiya , Korenko Michal , Šimko František , Ambrová Marta , Szatmáry Lórant , Rakhmatullin Aydar 
Published: October 2023

AbstractExperimental measurements were made to assess the electrical conductivity as a function of temperature and NdF3 concentration (0–20 mol %) of molten systems of (LiF–CaF2)eut–NdF3, (LiF–NaF)eut–NdF3, (NaF–CaF2)eut–NdF3 and (LiF–MgF2)eut–NdF3. The experiment used an altering current impedance spectroscopy technique with a platinum–rhodium electrode positioned in a pyrolytic BN tube and graphite a crucible/counter electrode. The conductivity of all systems under study increased with rising temperatures and decreasing NdF3 concentrations. The Arrhenius equation and linear regression have both been used to describe the experimental data. The results of the ionic conductivity for the temperature 850 °C and NdF3 concentrations 0, 10 and 15 mol %, respectively, can be compared as follows: the conductivity of the molten system of (LiF–CaF2)eut–NdF3 was determined to be 6.10, 5.95 and 5.10 S.cm−1, the results for the system (LiF–NaF)eut–NdF3 were 6.16, 5.56 and 4.13 S.cm−1, the results for the system (NaF–CaF2)eut–NdF3 were 3.78, 3.56 and 2.32 S.cm−1, and finally, the results for the system (LiF–MgF2)eut–NdF3 were determined to be for the same temperature as 5.35, 4.79 and 4.14 S.cm−1, respectively.
Entrepreneurial Leadership: Stärkenorientierte Online-Führungsausbildungen für Medienunternehmen im Transformationsprozess
Authors: Breyer-Mayländer Thomas , Zerres Christopher 
Published: October 2023

ZusammenfassungDie Medienbranche ist seit Jahren von disruptiven Veränderungen betroffen, sodass die Unternehmen und zentralen Akteure in einem dauerhaften Veränderungsmodus sind. Gestiegene Anforderungen an Führungskräfte, Kostendruck und geringe Zeitbudgets für Weiterbildung reduzieren die Möglichkeiten für umfassende Ausbildungsmöglichkeiten. Dieser Beitrag beschreibt einen Lösungsansatz, wie trotz begrenzter Budget- und Zeitressourcen eine individuelle Begleitung von Führungskräften möglich wird. Mit einer Kombination von stärkenorientierter Selbstreflexion und gezielten Impulsen werden Führungskräfte in ihrer Entwicklung als selbstverantwortliche, unternehmerisch denkende Führungskraft gestärkt.
The Emergence of Alternative Sociotechnical Imaginaries in Argentina’s Agricultural Sector: Lessons for Democracy and Sustainability
Authors: Deciancio Melisa , Siegel Karen M. 
Published: October 2023

AbstractThe question of how various actors envision sustainability transitions and which visions are translated into policy agendas is an important aspect of the sustainability–democracy debate. Applying Jasanoff’s concept of sociotechnical imaginaries, this paper examines how three alternative imaginaries of agricultural production—agroecology, organic production, and biodevelopment—have emerged in Argentina, as well as how they have established themselves economically and politically despite the dominance of the well-established soybean imaginary. Argentina’s return to democracy in 1983 was crucial for the emergence of alternative imaginaries because it enabled a new kind of relationship between the state and civil society that opened participation channels for alternative visions. Reflecting patterns that are also relevant to other South American countries, our analysis of the Argentinean case draws attention to the role inequality plays at different levels and its importance as an area for further research on the democracy–sustainability nexus.
Mixing times and hitting times for general Markov processes
Authors: Anderson Robert M. , Duanmu Haosui , Smith Aaron 
Published: October 2023

AbstractThe hitting and mixing times are two fundamental quantities associated with Markov chains. In Peres and Sousi [PS15] and Oliveira [Oli12], the authors show that the mixing times and “worst-case” hitting times of reversible Markov chains on finite state spaces are equal up to some universal multiplicative constant. We use tools from nonstandard analysis to extend this result to reversible Markov chains on general state spaces that satisfy the strong Feller property. Finally, we show that this asymptotic equivalence can be used to find bounds on the mixing times of a large class of Markov chains used in MCMC, such as typical Gibbs samplers and Metropolis–Hastings chains, even though they usually do not satisfy the strong Feller property.
“Far from the Space of Tolerance”: Hungary and the Biopolitical Geotemporality of Postsocialist Homophobia
Authors: Renkin Hadley Z. 
Published: October 2023

AbstractSexuality has long been central to ethnographic constructions of exotic difference, an index critically demarcating the borders of European Modernity and its negative and positive Others, and underpinning both extra-European colonial domination and modern biopolitical regimes of subjectivity, citizenship, and society. Representations of Eastern European sexuality, however, were also crucial to both Western and Eastern imaginings of modern “European” selves, politics, and societies, and their boundaries of belonging. Yet while recent scholarship has drawn attention to reemerging European orientalisms and sexuality’s salience in postsocialist politics, particularly in relation to recent postsocialist homophobias, little scholarly attention has been paid to the significance of these histories of European sexual difference for the biopolitical character of current borders of postsocialist difference. In this article I combine postcolonial theories of sexuality, geographies of European belonging, and postsocialist studies of sexual politics to analyze popular, political, and scholarly discourses surrounding sexual politics and homophobia in Hungary. Melding historical debates about Hungarian belonging, discursive analysis, and ethnographic fieldwork, I argue that dominant interpretations of these events constitute postsocialist homophobia as a particularly consequential “problem” reinscribing deeply rooted, and profoundly biopolitical, borders between Europe’s East and West. These readings not only naturalize an imagined West as a space of proper sexual citizenship and tolerance, masking its persistent heteronormativity; they also render Hungary a time–space of complex, ambiguous sexual-political resistance, essentializing its inhabitants as inevitable sexual others of Western Modernity: for some failures of proper sexual citizenship; for others avatars of alternative, sexually-traditional Europeanness.
Investigating the effect of outsole configurations on rotational and translational traction using a mechanical prosthetic foot
Authors: Keshvari Bahador , Lehoang Long , Senner Veit 
Published: October 2023

AbstractStudded football boots and their interaction with the pitch surface play a major role in generating traction and on the risk of injuries and performance. The aim of this study was to establish a methodological framework to predict a safe zone of traction for different specific football movements in natural preloads. We measured peak pressure distribution among 17 male football players in four specific football movements (cutting 135°, sprinting, turning, and penalty kick) on artificial turf using a baseline football boot with an insole pressure sensor. A mechanical prosthetic foot was adjusted to replicate similar peak pressure distribution based on these four movements. Traction was measured under three preloads: 400, 600, and 800 N. They were lower than those measured with the players to avoid damage to the mechanical test device. This procedure was conducted for seven different outsole configurations. Rotational and translational traction was estimated for high preloads (above 2000 N) using an artificial neural network. Our findings show pressure distribution is an important bridge between subjective measurement (field tests) and objective measurement (laboratory tests) for accurate traction measurement. Artificial neural networks can aid in finding the upper and lower ranges of traction in the natural preloads. Such findings could help footwear developers, trainers, players, and governing institutions to choose an appropriate football boot outsole according to the safe zone of traction established in this study.
Distribution and Abundance of Intertidal Sponge (Porifera) Communities in Coral Reefs of Singapore
Authors: Lim Shu Feng , Tan Lik Tong , Goh Beverly Pi Lee 
Published: October 2023

AbstractGiven the important functional roles of sponges in the coral reef community, few studies have looked at sponge community assemblages in Singapore. This study was conducted to assess the sponge diversity, species richness, and species abundance of intertidal sponge communities in Singapore’s coral reefs, including Pulau Hantu, P. Subar Laut, Tanjong Rimau, and Labrador Park. Belt transects measuring 10 m by 1 m were established to survey the sponge communities at these reef sites. Based on sponge morphology, a total of 28 morphospecies were identified, belonging to eight different sponge orders, namely Chondrillida, Clionaida, Dictyoceratida, Haplosclerida, Poecilosclerida, Suberitida, Tetractinellida, and Verongiida. Univariate statistical analyses revealed that sponge diversity, species richness, and abundance at P. Hantu site 2 were significantly higher than that in Labrador Park. In addition, multivariate statistical analyses showed that in terms of community structure, there were three distinct clusters found at P. Hantu site 2, Labrador Park, and P. Subar Laut. The formation of these distinct clusters was sponge species specific and shaped by environmental factors and anthropogenic stresses. Preliminary sponge data presented in this study contribute to the regional biogeography of sponges and could serve as baseline data for future studies, including ecological research and biomonitoring of marine invertebrates, and support marine conservation efforts in Singapore.