bluuebunny/crossref_metadata_2025_split huggingface dataset:
High depressive symptomatology reduces emotional reactions to pictures of social interaction
Authors: Lacerda Kíssyla Christine Duarte , Souza Fabiana Cristina de Oliveira , Araújo Cassia Regina Vieira , Mota Bruna Eugênia Ferreira , Muñoz Pedro Maria Guerra , Berger Willian , Vilete Liliane , Bearzoti Eduardo , Guerra Leal Souza Gabriela 
Published: January 2024

AbstractIndividuals with severe depressive symptoms present diminished facial expressions compared to healthy individuals. This reduced facial expression, which occurs in most depressive patients could impair social relationships. The current study sought to investigate whether pictures with social interaction cues could elicit different modulations of facial expressions and mood states in individuals with depressive symptoms compared to healthy individuals. A total of 85 individuals were divided into depressive and non-depressive groups based on their beck depression inventory scores. Participants viewed pictures containing neutral (objects), affiliative (people interacting socially), and control (people not interacting) scenes. Electromyographic signals were collected during the entire period of visualization of the blocks, and emotional questionnaires were evaluated after each block to assess sociability and altruism (prosocial states). In non-depressed individuals, affiliative pictures increased the activity of the zygomatic muscle compared to both neutral and control pictures and reduced fear of rejection compared to neutral pictures. During the visualization of the affiliative block, zygomatic major muscle activation was higher and fear of rejection was lower in the non-depressive individuals than in the depressive. These effects reflected the low expressions of smiling and sociability to affiliative pictures in depressive individuals. These findings highlight the importance of smiling and prosocial states in social interactions, especially in these individuals.
Naturally acquired antibodies against Plasmodium vivax pre-erythrocytic stage vaccine antigens inhibit sporozoite invasion of human hepatocytes in vitro
Authors: Ntumngia Francis Babila , Kolli Surendra Kumar , Annamalai Subramani Pradeep , Barnes Samantha J. , Nicholas Justin , Ogbondah Madison M. , Barnes Brian B. , Salinas Nichole D. , Thawornpan Pongsakorn , Tolia Niraj H. , Chootong Patchanee , Adams John H. 
Published: January 2024

AbstractIn Plasmodium vivax, the most studied vaccine antigens are aimed at blocking merozoite invasion of erythrocytes and disease development. Very few studies have evaluated pre-erythrocytic (PE) stage antigens. The P. vivax circumsporozoite protein (CSP), is considered the leading PE vaccine candidate, but immunity to CSP is short-lived and variant specific. Thus, there is a need to identify other potential candidates to partner with CSP in a multivalent vaccine to protect against infection and disease. We hypothesize that sporozoite antigens important for host cell infection are considered potential targets. In this study, we evaluated the magnitude and quality of naturally acquired antibody responses to four P. vivax PE antigens: sporozoite surface protein 3 (SSP3), sporozoite protein essential for traversal 1 (SPECT1), cell traversal protein of ookinetes and sporozoites (CelTOS) and CSP in plasma of P. vivax infected patients from Thailand. Naturally acquired antibodies to these antigens were prevalent in the study subjects, but with significant differences in magnitude of IgG antibody responses. About 80% of study participants had antibodies to all four antigens and only 2% did not have antibodies to any of the antigens. Most importantly, these antibodies inhibited sporozoite infection of hepatocytes in vitro. Significant variations in magnitude of antigen-specific inhibitory antibody responses were observed with individual samples. The highest inhibitory responses were observed with anti-CelTOS antibodies, followed by anti-SPECT1, SSP3 and CSP antibodies respectively. These data highlight the vaccine potential of these antigens in protecting against hepatocyte infection and the need for a multi-valent pre-erythrocytic vaccine to prevent liver stage development of P. vivax sporozoites.
Baseflow significantly contributes to river floods in Peninsular India
Authors: Sharma Shailza , Mujumdar P. P. 
Published: January 2024

AbstractExtreme rainfall prior to a flood event is often a necessary condition for its occurrence; however, rainfall alone is not always an indicator of flood severity. Antecedent wetness condition of a catchment is another important factor which strongly influences the flood magnitudes. The key role of soil moisture in driving floods is widely recognized; however, antecedent conditions of deeper saturated zone may contribute to river floods. Here, we assess how closely the flood magnitudes are associated to extreme rainfall, soil moisture and baseflow in 70 catchments of Peninsular India for the period 1979–2018. Annual flood magnitudes have declined across most of the catchments. Effect of flow regulations is also assessed to understand the impact of human interventions on flood characteristics. Reservoir regulation has positive effect by reducing the flood peak and volume, whereas the duration of flood events has increased after the construction of dams. Baseflow exhibits similar patterns of trends as floods, whereas trends in rainfall and soil moisture extremes are weakly correlated with trends in flood magnitudes. Baseflow is found to be more strongly influencing the flood magnitudes than soil moisture at various time lags. Further analysis with event coincidence analysis confirms that baseflow has stronger triggering effect on river floods in Peninsular India.
Evaluation of the benefits of neutral bicarbonate ionized water baths in an open-label, randomized, crossover trial
Authors: Ushikoshi-Nakayama Ryoko , Yamazaki Tomoe , Omagari Daisuke , Matsumoto Naoyuki , Inoue Hiroko , Nukuzuma Chiyoko , Nishino Seiji , Saito Ichiro 
Published: January 2024

AbstractWe previously demonstrated that neutral bicarbonate ionized water (NBIW) bathing enhances blood flow by bicarbonate ions and described the underlying mechanism. However, additional clinical investigation was warranted to investigate the efficacy of NBIW bathing. Hence, we performed a randomized, open-label, crossover trial to examine the effects of NBIW bathing on mental stress, sleep, and immune function. Participants who regularly felt stressed were randomly assigned to NBIW or regular bathing for 4 weeks. Mental stress was assessed with the Brief Job Stress Questionnaire (BJSQ) and the Profile of Mood States Second Edition; sleep quality, with the Pittsburgh Sleep Quality Index Japanese version (PSQI-J) and actigraphy; and immune function, with laboratory tests. PSQI-J scores and actigraphy sleep latency and bed out latency improved significantly more with NBIW bathing than with regular bathing (p < 0.05). Furthermore, NBIW bathing reduced both stress-induced fluctuations in CD4+ and CD8+ T cell counts and fluctuations in the naive to memory T cell ratio and neutrophil phagocytosis, indicating improved immune function. These findings suggest that daily NBIW bathing could improve mental stress, sleep quality, and immune function and bring about positive health effects in those who experience stress in their daily lives.
The relationship of atrial fibrillation with left atrial size in patients with essential hypertension
Authors: Saadeh Rami , Abu Jaber Bara , Alzuqaili Taqwa , Ghura Sara , Al-ajlouny Taiba , Saadeh Abdallah M. 
Published: January 2024

AbstractAtrial fibrillation (AF) is the most common sustained arrhythmia and it is a major public health problem worldwide. Hypertension is one of the major risk factors for the development of AF. This study is carried out to determine the prevalence and independent risk factors for atrial fibrillation (AF) in hypertensive patients and to evaluate the relationship of AF with left atrial size. This is a retrospective observational cross – sectional study that used a retrospective electronic chart review of all admitted patients to cardiology department at King Abdullah university hospital (KAUH) in Irbid, Jordan, with a diagnosis of hypertension along with various acute cardiac admissions, including AF during 1-year period (January 1st to December 31 of 2021). Risk factors for AF (age, sex, DM, coronary artery disease, valvular heart disease, Cor-pulmonale, obstructive sleep apnea, and congestive cardiac failure) were retrieved from electronic charts of the patients. A total of 958 patients were admitted to the coronary care unit (CCU) and intermediate care unit (IMCU) during a 1-year period. Among them, 276 had 2 or 3 admissions. The main reason of admission was acute coronary syndrome (n = 491), heart failure (n = 180), and AF (n = 144), indicating AF prevalence of 15%. However, there were 40 patients with combined causes. All patients in the study (n = 958) were diagnosed with hypertension, including patients with atrial fibrillation (n = 144). The mean age of patients was 61.4 (± 11.46) years, and approximately two thirds of them were males (65.4%). The binary logistic regression model demonstrated a significant statistical relationship of age, left atrial size, coronary artery disease, left ventricular ejection fraction, left ventricular dimensions in systole and diastole, and heart failure with the occurrence of AF after controlling for gender, smoking, and diabetes. Findings indicate that left atrial size plays a significant role in the development of AF in patients with hypertension. However, the prevalence of AF significantly increased with advancing age in both sexes because of increased left ventricular hypertrophy, which leads to increased left atrial size.
Anatomical considerations for nerve transfer in axillary nerve injury
Authors: Kim Soo-Jung , Bang Jong-Ho , Yang Hee-Jun , Moon Seong-Hwan , Choi Yun-Rak , Lee Hye-Yeon 
Published: January 2024

AbstractThis study investigated the anatomical details of the axillary and radial nerves in 50 upper limbs from 29 adult formalin-embalmed cadavers, and ten fresh upper limbs. The focus was on understanding the course, division, and ramifications of these nerves to improve treatment of shoulder dysfunction caused by axillary nerve damage. The axillary nerve divided anteriorly and posteriorly before passing the quadrangular space in all specimens, with specific distances to the first ramifications. It was found that the deltoid muscle's clavicular and acromial parts were always innervated by the anterior division of the axillary nerve, whereas the spinous part was variably innervated. The longest and thickest branches of the radial nerve to the triceps muscles were identified, with no statistically significant differences in fiber numbers among triceps branches. The study concludes that nerve transfer to the anterior division of the axillary nerve can restore the deltoid muscle in about 86% of shoulders, and the teres minor muscle can be restored by nerve transfer to the posterior division. The medial head branch and long head branch of radial nerve were identified as the best donor options.
Implementation of cloud computing in the German healthcare system
Authors: Putzier M. , Khakzad T. , Dreischarf M. , Thun S. , Trautwein F. , Taheri N. 
Published: January 2024

AbstractWith the advent of artificial intelligence and Big Data - projects, the necessity for a transition from analog medicine to modern-day solutions such as cloud computing becomes unavoidable. Even though this need is now common knowledge, the process is not always easy to start. Legislative changes, for example at the level of the European Union, are helping the respective healthcare systems to take the necessary steps. This article provides an overview of how a German university hospital is dealing with European data protection laws on the integration of cloud computing into everyday clinical practice. By describing our model approach, we aim to identify opportunities and possible pitfalls to sustainably influence digitization in Germany.
Spatiotemporal heterogeneity reveals urban-rural differences in post-disaster recovery
Authors: Park Sangung , Yao Tong , Ukkusuri Satish V. 
Published: January 2024

AbstractA post-disaster recovery process necessitates significant financial and time investment. Previous studies have found the importance of post-disaster spatial recovery heterogeneity, but the recovery heterogeneity has not been extended to the directed recovery relationships despite the significance of sequential recovery plans. Identifying a causal structure between county-level time series data can reveal spatial relationships in the post-disaster recovery process. This study uses a causal discovery method to reveal the spatiotemporal relationships between counties before, during, and after Hurricane Irma in 2017. This study proposes node aggregation methods at different time scales to obtain internally validated causal links. This paper utilizes points of interest data with daily location information from mobile phones and county-level daily nighttime light data. We find intra-regional homogeneity, inter-regional heterogeneity, and a hierarchical structure among urban, suburban, and rural counties based on a network motif analysis. Subsequently, this article suggests county-level post-disaster sequential recovery plans using the causal graph methods. These results help policymakers develop recovery scenarios and estimate the corresponding spatial recovery impacts.
First-in-human phase I dose escalation trial of the first-in-class tumor microenvironment modulator VT1021 in advanced solid tumors
Authors: Mahalingam Devalingam , Harb Wael , Patnaik Amita , Bullock Andrea , Watnick Randolph S. , Vincent Melanie Y. , Chen Jian Jenny , Wang Suming , Pestana Harold , Chao Judy , Mahoney James , Cieslewicz Michael , Watnick Jing 
Published: January 2024

Abstract
Background
VT1021 is a cyclic peptide that induces the expression of thrombospondin-1 (TSP-1) in myeloid-derived suppressor cells (MDSCs) recruited to the tumor microenvironment (TME). TSP-1 reprograms the TME via binding to CD36 and CD47 to induce tumor and endothelial cell apoptosis as well as immune modulation in the TME.

Methods
Study VT1021-01 (ClinicalTrials.gov ID NCT03364400) used a modified 3 + 3 design. The primary objective was to determine the recommended Phase 2 dose (RP2D) in patients with advanced solid tumors. Safety, tolerability, and pharmacokinetics (PK) were assessed. Patients were dosed twice weekly intravenously in 9 cohorts (0.5–15.6 mg/kg). Safety was evaluated using CTCAE version 5.0 and the anti-tumor activity was evaluated by RECIST version 1.1.

Results
The RP2D of VT1021 is established at 11.8 mg/kg. VT1021 is well tolerated with no dose-limiting toxicities reported (0/38). The most frequent drug-related adverse events are fatigue (15.8%), nausea (10.5%), and infusion-related reactions (10.5%). Exposure increases proportionally from 0.5 to 8.8 mg/kg. The disease control rate (DCR) is 42.9% with 12 of 28 patients deriving clinical benefit including a partial response (PR) in one thymoma patient (504 days).

Conclusions
VT1021 is safe and well-tolerated across all doses tested. RP2D has been selected for future clinical studies. PR and SD with tumor shrinkage are observed in multiple patients underscoring the single-agent potential of VT1021. Expansion studies in GBM, pancreatic cancer and other solid tumors at the RP2D have been completed and results will be communicated in a separate report.
A two‐stage solution method for the design problem of medium‐thick plates in steel plants
Authors: Peng Gongzhuang , Zhang Boyu , Jiang Shenglong 
Published: January 2024

AbstractThe medium‐thick plate is an important type of steel product widely used in construction and engineering machinery. The orders are usually characterised by multiple specifications and small quantities. The plate design is an important part in the production process of medium‐thick plate, which includes the combination of sub‐plates and the size design of the motherboard. A multi‐objective model for medium‐thick plate design is proposed based on the 2D bin packing model, comprehensively considering spatial and size constraints of the plate production. A two‐stage genetic algorithm (TSGA) is developed to solve the proposed model. In the first stage, an improved GA is used to optimise the corresponding relationship between the sub‐plates and the slab, as well as the size of the motherboard. In the second stage, an exact algorithm based on the integer programming model is applied to calculate the order layout to minimise the surplus materials. To validate the proposed method, computational experiments are conducted based on actual production data from a steel plant. The experimental results show the effectiveness of the TSGA algorithm in solving the plate design problem.
Fault estimation for nonlinear uncertain time‐delay systems based on unknown input observer
Authors: Azarbani Ataollah , Fakharian Ahmad , Menhaj Mohammad Bagher 
Published: January 2024

AbstractIn this paper, a novel nonlinear unknown input observer is proposed in order to fault estimation for nonlinear uncertain systems with time delays. By the estimation of the faults, the features are detected such as shape, size occurrence time etc. The time delay is considered a constant and known parameter in the states. The disturbances are investigated in the states and outputs and also, and sensor and actuator faults are considered. The stability of the closed‐loop system is guaranteed by Lyapunov–Krasovskii theory and some feasible Linear matrix inequalities (LMI). The proposed method is simulated on a continuous‐stirred tank reactor (CSTR) with uncertainties and time delay. Simulation results show the appropriate efficiency of the proposed method.
A 3‐D metal printed folded‐shorted patch array with an integrated feeding circuit offering dual‐band circularly polarised radiation for cubesat applications
Authors: Li Yuepei , Rao Jiayu , Wang Lei , Ding Yuan , Podilchak Symon K. 
Published: January 2024

AbstractThis letter presents a three‐dimensional (3‐D) printed metallic antenna array that combines folded‐shorted patches (FSPs) and meandering for structure compactness. The design provides dual‐band functionality, operating in the L‐band and the S‐band. The compact and broadband feeding network, which is also integrated onto the backside of the antenna ground plane, enables circularly polarised radiation over an operational bandwidth of more than 80%. The dimensions of the array are 0.4 × 0.4 × 0.056 (where λ0 is the free space wavelength at 1.2 GHz), making the design suitable for CubeSats and other space constraint applications. The measured right‐handed circular polarised realised gains are 2.32 dBic and 1.84 dBic at 1.2 GHz and 2.45 GHz, respectively. In addition, the 3‐D metallic printed FSP elements can be flexibly arranged for different link requirements and other applications like beam steering.
New single‐stage bidirectional three‐phase ac‐dc solid‐state transformer
Authors: Kopacz Rafał , Menzi David , Krismer Florian , Rąbkowski Jacek , Kolar Johann W. , Huber Jonas 
Published: January 2024

AbstractHigh‐power applications with low‐voltage (LV) dc loads, for example, fast charging stations for electric vehicles (EVs), are typically supplied from the medium‐voltage (MV) grid. Aiming for low volume, MVac‐LVdc solid‐state transformers (SSTs) that provide galvanic separation with medium‐frequency transformers (MFTs) are thus considered, which are conventionally realized as two‐stage systems that consist of an ac‐dc power‐factor‐correction (PFC) rectifier and an isolated dc‐dc converter. This letter extends a new single‐stage isolated bidirectional PFC rectifier concept to MV levels, resulting in an SST that performs MVac‐LVdc conversion in a single converter stage and, unlike many modular SST concepts, employs only a single MFT. The SST's primary side operates modular‐multilevel‐converter (MMC) bridge legs, whose input voltages contain large ac components, in the quasi‐two‐level mode to minimize the cell capacitors. The secondary side employs a standard LV three‐phase rectifier, and a dual‐active‐bridge‐(DAB)‐like modulation strategy allows power flow regulation and ensures sinusoidal grid currents. The concept is explained and validated using detailed circuit simulations of an exemplary 1‐MW system operating between a 10‐kV three‐phase grid and an 800‐V dc output. The component stresses are evaluated, and an efficiency of 98.1% and a power density of up to 0.6 kW/dm3 are estimated.
Analysis of waist and wrist positioning wearable machine learning models to detect falls
Authors: Ordoñez Nuñez Teddy , Garcia Ramirez Alejandro Rafael , Becherán Marón Liliam 
Published: January 2024

AbstractFalls have a global impact, affecting people worldwide, with a notably high occurrence among the elderly. This study employs machine learning techniques to analyze falls and simulate Activities of Daily Living (ADL). The objective is to predict human falls by leveraging signals from accelerometers and gyroscopes as wearable sensors. By deriving statistical features such as mean, standard deviation, and range the authors successfully trained and assessed six machine learning models allowing them to compare solutions based on both wrist and waist data. The combination of these characteristics and sensors resulted in the Random Forest waist model achieving the most favorable metrics, with an accuracy rate of 97.22% in a 5‐s window.
Robust receive beamforming and reflection coefficients optimization in an IRS‐aided decode‐and‐forward relay system
Authors: Lu Yingxing , Huang Yongwei 
Published: January 2024

AbstractConsider a decode‐and‐forward wireless relay system assisted by an intelligent reflection surface (IRS), where a robust design on receive beamforming at the relay and reflection coefficients at the IRS is studied. The worst‐case signal‐to‐noise ratio maximization problem is formulated, subject to the reflection coefficients (with either continuous or discrete phases) constraints, under the assumption of imperfect channel state information for all channels. To cope with the hard problem, an equivalent nonconvex quadratic optimization problem with a simpler form is derived, and then the Cauchy‐Schwarz inequality is applied to update the beamforming and a cyclic process is proposed to update the reflection coefficients, where a closed‐form optimal solution is computed in each step. It turns out that the proposed algorithm achieves a locally optimal solution for the robust design problem. Simulation results show that the proposed robust design outperforms an existing non‐robust design and two robust designs via semidefinite relaxation technique.