bluuebunny/crossref_metadata_2025_split huggingface dataset:
ANDROID-BASED SMART SYSTEM FOR FRUIT SELECTION TO PREVENT TODDLER STUNTING
Authors: Riansah Wahyu , Lumban Gaol Nur Yanti 
Published: January 2025

Abstract: Preventing stunting in toddlers is crucial for improving children's health and growth. Stunting occurs due to chronic nutritional deficiencies during the first 1,000 days of a child's life, affecting their height, cognitive development, and immune system, which can reduce their future potential. Fruits play an important role in a toddler's diet because they are rich in vitamins, minerals, fiber, antioxidants, and other bioactive compounds that support physical growth and brain development. However, selecting the right fruits is vital because some fruits can cause digestive issues or allergies in toddlers. To assist parents in choosing the right fruits, a mobile-based expert system using the Certainty Factor method has been developed. This system provides recommendations based on the toddler's health condition and evaluates the nutritional content of fruits. With this system, parents can ensure that their toddlers receive optimal nutrition, contributing to stunting prevention and ensuring that the toddlers grow up healthy, intelligent, and with full potential in the future Choosing the right fruits and maintaining a balanced nutrition are crucial parts of supporting the sustainability of stunting prevention efforts. Keywords: certainty factor method; expert system; fruit selection; stunting prevention; toddler nutrition Abstrak: Pencegahan stunting pada batita sangat penting untuk meningkatkan kualitas kesehatan dan pertumbuhan anak. Stunting terjadi akibat kekurangan gizi kronis pada 1.000 hari pertama kehidupan batita, memengaruhi tinggi badan, perkembangan kognitif, dan sistem imun anak, yang berisiko mengurangi potensi masa depan mereka. Buah-buahan memiliki peran penting dalam pola makan batita, karena kaya akan vitamin, mineral, serat, antioksidan, dan senyawa bioaktif yang mendukung pertumbuhan fisik dan perkembangan otak. Namun, pemilihan buah yang tepat sangat penting karena beberapa buah dapat menyebabkan masalah pencernaan atau alergi pada batita. Untuk membantu orang tua dalam memilih buah yang sesuai, dikembangkan sistem pakar berbasis mobile dengan metode Certainty Factor. Sistem ini memberikan rekomendasi berdasarkan kondisi kesehatan batita, serta mengevaluasi kandungan nutrisinya. Dengan sistem ini, orang tua dapat memastikan bahwa batita mendapatkan nutrisi yang optimal dengan berkontribusi dalam pencegahan stunting dengan memastikan batita tumbuh sehat, cerdas, dan memiliki potensi penuh di masa depan. Pemilihan buah yang tepat dan nutrisi yang seimbang menjadi bagian penting dalam mendukung upaya keberlanjutan pencegahan stunting. Kata kunci: batita; metode certainty factor; pemilihan buah; pencegahan stunting; sistem cerdas
APPLICATION OF SIMPLE ADDITIVE WEIGHTING METHOD IN SELECTING ACCESSORY SUPPLIERS AT AL-FAZZA COSMETIC STORE
Authors: Rani Maha , Christy Tika , Ardiansyah Ricki , Sovia Rini 
Published: January 2025

AbstractAl-Fazza Cosmetic Store is a store engaged in the sale of cosmetics. In an effort to develop and increase sales value, Al-Fazza Store began selling various accessories such as bracelets, necklaces, hair clips and headscarves. To get quality goods and maximum profit, supplier selection is important. However, supplier selection is a problem because each supplier has its own advantages and disadvantages and uniqueness. To help select suppliers at the Al-Fazza Cosmetic Store, the decision support system can provide decision recommendations quickly and accurately based on the criteria given by the decision maker. The method that will be used in processing data and determining decisions in this decision support system is simple additive weighting (saw). The decision results provided by this method can be used as recommendations by decision makers in determining the best supplier. Keywords: simple additive weighting; information systems; decision support systems; suppliers Abstrak: Toko Kosmetik Al-Fazza merupakan toko yang bergerak di bidang penjualan kosmetik. Dalam upaya untuk mengembangkan dan meningkatkan nilai penjualan, Toko Al-Fazza mulai menjual berbagai aksesoris seperti gelang, kalung, jepit rambut, dan jilbab. Untuk mendapatkan barang yang berkualitas dan keuntungan yang maksimal, pemilihan supplier merupakan hal yang penting. Akan tetapi, pemilihan supplier menjadi suatu permasalahan karena setiap supplier memiliki kelebihan dan kekurangan serta keunikannya masing-masing untuk membantu pemilihan supplier pada Toko Kosmetik Al-Fazza. Sistem pendukung keputusan tersebut dapat memberikan rekomendasi keputusan secara cepat dan tepat berdasarkan kriteria yang diberikan oleh pengambil keputusan. Metode yang akan digunakan dalam pengolahan data dan penentuan keputusan pada sistem pendukung keputusan ini adalah simple additive weighting (saw). Hasil keputusan yang diberikan oleh metode ini dapat digunakan sebagai rekomendasi oleh pembuat keputusan dalam menentukan supplier terbaik. Kata kunci: simple additive weighting; sistem informasi; sistem penunjang keputusan;pemasok
A NEW VISION OF ENZYMATIC PROCESSES AND THE YIELD OF CEREALS WITH THE PAR­TICIPATION OF MOLECULAR OXYGEN IN THE CONTEXT OF THE NATIONAL INTERESTS OF UKRAINE
Authors: Panchenko Oleksandr , Sukhyna Maryna 
Published: January 2025

Oxygen is the elixir of life for all aerobic organisms on Earth. It makes up 21% of the air we breathe, but that wasn't always the case. Initially, our planet's atmosphere was full of carbon dioxide, so only primitive anaerobic organisms, which do not need oxygen for living, could survive. But then a miracle happened: cyanobacteria, tiny organisms, began to use the energy of sunlight to assimilate carbon dioxide and water, a process now known as photosynthesis, which produces molecular oxygen from a water molecule as a by-product. The period that followed is known as the Great Oxygen Catastrophe, as the emergence and accumulation of a new two-atom molecule in the atmosphere led to the butterfly effect, an irreversible event that made our planet what it is today [1]. In turn, this event led to the emergence of multicellular life, which can exist and thrive on Earth with the help of oxygen. In addition to respiration, oxygen protects us from the Sun's harsh ultraviolet radiation through the Schumann-Runge absorption and in the 175–205 nm range and creates an ozone layer in the stratosphere that protects us from the softer UV rays of 240 nm.
Oxygen has been the subject of intense research for more than two centuries, ever since the Swedish chemist Scheele first obtained this pure gas by decomposing black magnesia. However, the mechanisms of reactions involving oxygen in living organisms are still not fully understood. It is now known that reactions of oxygen with organic compounds are forbidden by spin, but photosynthesis and respiration are vivid examples of how this prohibition can be overcome. The O2 molecule has two unpaired electrons (spins) on the outer electron shell, whereas almost all organic matter is diamagnetic and has zero spin.
How molecular oxygen overcomes spin prohibition during its activation by enzymes is discussed in this article. Particular attention is paid to understanding reaction mechanisms in living organisms, using photosynthesis and respiration as examples. Furthermore, the topi­cal area of studying the mechanism of the Ribulose-1,5-bisphosphate carboxylase (RuBisCo) is emphasized, which offers the possibility of developing new approaches to increasing ce­real yields for farmers.
MICROWAVE DIELECTRICS FOR APPLICATIONS IN THE 5G FR3 RANGE
Authors: Fedorchuk Oleksandr , V’yunov Oleg , Plutenko Tetiana , Belous Anatolii 
Published: January 2025

The 5G FR3 band requires low-permittivity materials. Spinel-structured materials, like SrY2O4, are promising due to their high Q-factor and tunability. However, their practical performance limits in terms of frequency range need further investigation. Planar technologies like microstrip lines and metamaterials, using these materials as substrates, can enable efficient and high-frequency devices for 5G and beyond.
This study aimed to synthesize ceramic materials with the compositions SrY2O4and SrYSmO4, possessing a spinel structure, and investigate their properties. The potential application of these materials in millimeter-wave devices and instruments was explored by mo­deling the spectral characteristics of antennas utilizing these materials as substrates and comparing the results with those obtained from li­terature-reported materials.
High-purity (≥99%) SrCO3, CaCO3, Sm2O3, and Y2O3 powders were employed as starting materials. Stoichiometric quantities of the raw materials were mixed, ball-milled, dried, sieved, calcined, and re-milled. A binder was added, and the mixture was pressed into pellets. The green compacts were sintered at temperatures ranging from 1480 to 1560 °C for durations of 2–6 hours, with a heating and cooling rate of 200 °C/h.
A quality factor Q×f = 89400 at a frequency of 11 GHz was achieved with a dielectric permittivity εr = 15.4 and a near zero temperature coefficient of dielectric permittivity/frequency TКε. The substitution of yttrium with samarium further decreased the dielectric permitti­vity to 9.4 but significantly reduced the quality factor of the material Q·f = 17800. The obtained SrY2O4 meets the requirements for dielectric materials in the centimeter wave range. It surpasses most materials in the millimeter wave range presented in the literature in terms of characteristics set.
Modeling of an antenna cell based on a double split-ring resonator showed the possibility of using microstrip materials and metamaterials with substrates made of the prepared materials in the frequency range of 8.6–11 GHz and adjacent ranges, which are used in satellite communication and television systems, aviation, weather, and police radars, line-of-sight (LOS) communication systems and electronic news gathering (ENG) systems.
REGULARITIES OF HYDROGEN EVOLUTION FROM ALKALINE SOLUTION AT CATHODES SINTERED FROM NICKEL, TUNGSTEN AND TUNGSTEN SILICIDE POWDERS
Authors: Pirskyy Yuriy , Manilevich Fedor , Kutsyi Andrii , Bogdanova Alina 
Published: January 2025

Among the known methods of hydrogen generation, electrochemical water splitting is an attractive technology that does not pollute the environment with carbon oxides and allows obtaining a high-purity product.However, it requires significant energy resources and is therefore not cost-effective enough.One of the obvious ways to eliminate this drawback is the creation and use of catalytically active cathodes on which hydrogen is evolved with a low voltage at a high exchange current.In addition, cathodes that do not contain precious metals and have high chemical resistance in an electrolyte solution have potential for practical application.
In this work, composite cathodes sintered from mixtures of two (Ni + WSi2) and three (Ni + W + WSi2) powders were manufactured, studied, and used to evolve hydrogen from a 30% KOH solution.It was found that new phases (NiWSi, W5Si3, SiC, NiW) were formed during powder sintering at 1200 C, and the resulting electrode materials had a highly developed and microstructured surface. The overpotential of hydrogen evolution from 30 % KOH solution at 26 °C on the cathode based on three powders was lower than on the cathode based on two powders, and it significantly decreased with increasing temperature to 70 °C.In addition, the electrode based on Ni + W + WSi2 had a higher exchange current and lower activation energy of hydrogen evolution than the electrode based on Ni + WSi2.Therefore, the cathode based on three powders was more active in the hydrogen evolution reaction than the cathode based on two powders.At the same time, the rate of hydrogen evolution on both cathodes was controlled by kinetic limitations, as evidenced by high activation energy values ​​(59.7 kJ/mol on Ni + WSi2 based cathode and 56.8 kJ/mol on Ni + W + WSi2 based cathode).The angular coefficients of the linear sections of the Tafel dependences of hydrogen evolution on both cathodes had close values ​​(b = at α ≈ 0.5), from which a conclusion was made about the same stage mechanism of the electrode process on such cathodes with a limiting electrochemical stage of formation of adsorbed hydrogen atoms.
Considering the low cost, high chemical resistance and sufficiently high activity of Ni + W + WSi2 based cathode in the reaction of hydrogen evolution from an alkaline solution at elevated temperatures, it can be considered promising for practical application.
ACCELERATING EFFECT OF 3-AMINOPROPYLOLIGOMERIC SILSESQUIOXANE ON FORMATION KINETICS OF THERMOSTABLE HYBRID NANOCOMPOSITES BASED ON POLYCYANURATE NETWORK.
Authors: Shulzhenko Diana , Grigoryeva Olga , Gumenna Mariana , Polunkin Evgen , Gorelov Borys , Fainleib Alexander , Grande Daniel 
Published: January 2025

In this work, reactive 3-aminopropyloligomeric silsesquioxane (AP-OSS) was synthesized and stu­died, and the effect of AP-OSS depending on its content (0.1–1.0 wt.%) on the kinetics of polycyclotri­merization of dicyanate ester of bisphenol E (DCBE) was determined using the dynamic DSC method. AP-OSS was prepared in high yield by the hydrolysis and polycondensation of 3-aminopropyltrimethoxysilane in a mixture of acetonitrile and ethanol, with tetrabutylammonium hydroxide (But4NOH) as a catalyst. The chemical structure of the synthesized AP-OSS was confirmed by the results of FTIR and 1H NMR spectroscopies, as well as by MALDI-TOF method. The FTIR spectra showed broad and intensive stretching absorption bands centered at ν≈ 3431 and ν≈ 3378 cm–1 and bending absorption bands centered at δ≈ 1638 and δ≈ 1599 cm-1 of the N–H in NH2 groups, as well as the absorption bands centered at ν≈1027 and δ≈859 cm–1, attributed to the special characteristic vibrations of the silsesquioxane cage Si–O–Si. MALDI-TOF spectroscopy detected predominantly singly charged protonatedions, indicating that the degree of oligomerization in this silsesquioxane is between n = 3 and 10. It was found that AP-OSS accelerated the DCBE polycyclotrimerization allowing decreasing the final temperature and time of polycyanurate network (PCN) synthesis, the higher content of the AP-OSS the higher acceleration effect has been observed. It was supposed that during the in situ synthesis of the hybrid PCN/AP-OSS nanocomposites, the amino groups on a surface of AP-OSS nanoparticles chemically interact with –O–C≡N-groups of DCBE with formation of isourea fragments providing the covalent embedding of AP-OSS into the growing PCN matrix. Using DSC method, it was found that all synthesized hybrid PCN/AP-OSS nanocomposites possessed high glass transition temperatures (Tg>280oC) and can be classified as thermally stable polymer materials.
Metal ion-crosslinking multifunctional hydrogel microspheres with inflammatory immune regulation for cartilage regeneration
Authors: Xu Zhuoming , Ma Jun , Hu Hanyin , Liu Jintao , Yang Haiyang , Chen Jiayi , Xu Hongwei , Wang Xinyu , Luo Huanhuan , Chen Gang 
Published: January 2025

IntroductionOsteoarthritis (OA) is a degenerative disease of the joints characterized by cartilage degradation and synovial inflammation. Due to the complex pathogenesis of OA, multifaceted therapies that modulate inflammatory and immune microenvironmental disturbances while promoting cartilage regeneration are key to control the progression of OA.MethodsHerein, a multifunctional nanoparticle (DIC/Mg-PDA NPs) was constructed successfully by the metal chelation effect between Mg2+ and catecholamine bond from dopamine, followed by the amidation with diclofenac (DIC), which was then prepared into an injectable hydrogel microsphere (DIC/Mg-PDA@HM) with immune-regulating and cartilage-repairing abilities through microfluidic technology for the treatment of osteoarthritis.Results and discussionThe sustained release of Mg2+ from the composite hydrogel microspheres achieved inflammatory immune regulation by converting macrophages from M1 to M2 and promoted cartilage regeneration through the differentiation of BMSCs. Moreover, the enhanced release of DIC and polydopamine (PDA) effectively downregulated inflammatory factors, and finally achieved OA therapy. In addition, in vivo MRI and tissue section staining of OA model proved the significant efficacy of the hydrogel microspheres on OA. In conclusion, these novel hydrogel microspheres demonstrated a promising prospect for multidisciplinary repairing of OA.
BMP9 induces postnatal zonal stratification of immature articular cartilage through reconfiguration of the existing collagen framework
Authors: Anderson-Watters Miles , Khan Ilyas M. 
Published: January 2025

Articular cartilage lines bones in synovial joints, and its main structural element, collagen, has an arcade-like arrangement formed from an initially random network in a process called postnatal maturation. This reshaping of the extracellular matrix is similar across all species and is critical for the lifelong strength and durability of cartilage. Collagen remodelling during maturation is difficult to study because it spans a period of time between birth and puberty, and in larger animals this can be months or years. In this study, we show that growth factor bone morphogenetic protein-9 (BMP9) induces collagen remodelling in intact immature articular cartilage explants within 21 days, generating the characteristic arcade-like structure and zonal anisotropic architecture of adult cartilage. In explants exposed to BMP9, collagen fibrils underwent angular displacement from 19° to 78° with respect to the surface, cell density decreased 1.77-fold, and chondrons were significantly larger. The absence of labelling with anti-COL2¾m, a marker of collagen turnover, showed that the existing fibril network was restructured. We found that stromelysin-1 (metalloproteinase-3, MMP3) gene expression was consistently upregulated, whilst other MMP transcript levels were unchanged or reduced. Remodelling was dependent on proteoglycan turnover and could be inhibited using PD166973. These data suggest a possible mechanism whereby MMP3 induces proteoglycan turnover and depolymerises collagen fibrils enabling them to undergo spatial reorganisation. This process may be driven by tissue swelling, which generates directional strain to align fibrils into an arcade-like pattern. The ability to induce tissue maturation advances the potential for engineering durable and functional cartilage for patients requiring joint repair due to diseases such as osteoarthritis.
Effect of ticagrelor combined with metoprolol extended-release tablets on cardiac function and clinical prognosis in elderly patients with acute coronary syndrome after percutaneous coronary intervention
Authors: Wang Lili , Gao Linlin , Chen Qin , Chen Li , Xu Hui , Sun Ling , Hu Youbin 
Published: January 2025

BackgroundAcute coronary syndrome (ACS) poses significant risks to older individuals. This study sought to assess the impact of combining ticagrelor and metoprolol extended-release tablets on clinical prognosis and cardiac function in elderly ACS patients following percutaneous coronary intervention (PCI).MethodsFrom February 2022 to February 2023, 90 elderly ACS patients who underwent PCI at our institution were retrospectively enrolled and divided into two groups: an observation group (OG) and a control group (CG), with 45 patients in each group. The CG received oral metoprolol extended-release tablets, while the OG received both oral metoprolol extended-release tablets and ticagrelor. Prognostic indicators and cardiac function were evaluated before and after treatment.ResultsThe treatment effectiveness rate in the OG was 97.78%, significantly higher than the CG's rate of 77.78% (P &lt; 0.05). Post-treatment, the OG displayed notable improvements in cardiac function, including significantly higher left ventricular ejection fraction (LVEF), stroke volume (SV), cardiac output (CO), and cardiac index (CI) compared to the CG (P &lt; 0.05). Both groups experienced enhanced exercise capacity, as evidenced by longer exercise duration (ED) and improved 6-min walking test (6MWT) results, with the OG showing superior gains (P &lt; 0.05). Additionally, the OG had significantly higher serum levels of cardiac troponin T (cTnT) and creatine kinase isoenzyme (CK-MB) than the CG (P &lt; 0.05). Decreases in serum levels of sICAM-1, MMP-9, and hs-CRP were observed in both groups, with more pronounced improvements in the OG (P &lt; 0.05). The incidence of adverse prognostic events in the OG was significantly lower at 8.89%, compared to 37.78% in the CG (P &lt; 0.05).ConclusionTicagrelor combined with metoprolol extended-release tablets can significantly improve cardiac function, motor performance, and quality of life in ACS patients after PCI. Additionally, it effectively increases myocardial injury markers and reduces serum inflammatory factor levels.
Effect of SY009, a novel SGLT1 inhibitor, on the plasma metabolome and bile acids in patients with type 2 diabetes mellitus
Authors: Yang Haoyi , Zhang Yuwen , Hong Yuxin , Wei Yuan , Zhu Yuning , Huang Lei , Yang Yuanxun , Sun Runbin , Li Juan 
Published: January 2025

ContextAs a novel SGLT1 inhibitor, SY-009 has been preliminarily confirmed in a phase Ib clinical study for its ability to reduce postprandial blood glucose in patients with type 2 diabetes mellitus (T2DM). However, the effects of SY-009 on human plasma metabolomics are still unknown.ObjectiveThis study aimed to explore the effects of SY-009 on plasma metabolomics in patients with T2DM and the potential metabolic regulatory mechanism involved.Study designIn the phase Ib study, a total of 50 participants with T2DM were enrolled and randomly assigned to the 0.5 mg BID, 1 mg BID, 2 mg BID, 1 mg QD, and 2 mg QD dose groups, with a 4:1 random allocation within each group to receive either the SY-009 capsule or placebo. We conducted untargeted and targeted metabolomics analyses on plasma samples from the phase Ib clinical study.ResultsUntargeted metabolomics revealed that, after SY009 treatment, there were differences in metabolic pathways, including primary bile acid biosynthesis; biosynthesis of unsaturated fatty acid; steroid hormone biosynthesis; purine metabolism; phenylalanine, tyrosine and tryptophan biosynthesis. In particular, the increase in bile acid-related metabolites in the 2 mg BID group was significantly greater than that in the placebo group, and unsaturated fatty acid-related metabolites decreased in both the 2 mg BID group and the placebo group, but there was no significant difference between the two groups. After comprehensive consideration, bile acids were taken as our target for accurate quantification via targeted metabolomics. Compared with those in the placebo group, the levels of several bile acids were significantly greater in the SY-009-treated groups. Moreover, the proportion of free bile acids decreased significantly, the proportion of glycine-conjugated bile acids increased significantly, the proportion of taurine-conjugated bile acids tended to be stable, and PBA/SBA significantly increased after SY-009 administration.ConclusionsSY-009 caused a series of postprandial plasma metabolite changes in patients with T2DM, especially significant changes in the bile acid profile, which provides a new perspective on the mechanism by which SY-009 lowers blood glucose.Clinical trial registrationhttps://www.clinicaltrials.gov, identifier NCT04345107.