bluuebunny/crossref_metadata_2025_split huggingface dataset:
Continuous glucose monitoring captures glycemic variability in obesity after sleeve gastrectomy: A prospective cohort study
Authors: Dorcely Brenda , DeBermont Julie , Gujral Akash , Reid Migdalia , Vanegas Sally M. , Popp Collin J. , Verano Michael , Jay Melanie , Schmidt Ann Marie , Bergman Michael , Goldberg Ira J. , Alemán José O. 
Published: January 2024

AbstractObjectiveHbA1c is an insensitive marker for assessing real‐time dysglycemia in obesity. This study investigated whether 1‐h plasma glucose level (1‐h PG) ≥155 mg/dL (8.6 mmol/L) during an oral glucose tolerance test (OGTT) and continuous glucose monitoring (CGM) measurement of glucose variability (GV) better reflected dysglycemia than HbA1c after weight loss from metabolic and bariatric surgery.MethodsThis was a prospective cohort study of 10 participants with type 2 diabetes compared with 11 participants with non‐diabetes undergoing sleeve gastrectomy (SG). At each research visit; before SG, and 6 weeks and 6 months post‐SG, body weight, fasting lipid levels, and PG and insulin concentrations during an OGTT were analyzed. Mean amplitude of glycemic excursions (MAGE), a CGM‐derived GV index, was analyzed.ResultsThe 1‐h PG correlated with insulin resistance markers, triglyceride/HDL ratio and triglyceride glucose index in both groups before surgery. At 6 months, SG caused 22% weight loss in both groups. Despite a reduction in HbA1c by 3.0 ± 1.3% in the diabetes group (p < 0.01), 1‐h PG, and MAGE remained elevated, and the oral disposition index, which represents pancreatic β‐cell function, remained reduced in the diabetes group when compared to the non‐diabetes group.ConclusionsElevation of GV markers and reduced disposition index following SG‐induced weight loss in the diabetes group underscores persistent β‐cell dysfunction and the potential residual risk of diabetes complications.
Analysis of the microstructural connectivity and compressive behavior of particle aggregated silica aerogels
Authors: Xiong Weibo , Abdusalamov Rasul , Itskov Mikhail , Milow Barbara , Rege Ameya 
Published: January 2024

AbstractPorous media such as aerogels can exhibit unique properties including low thermal conductivity, low bulk density, and low sound velocity. However, the limited mechanical properties of aerogels restrict their widespread application. This study focuses on understanding the mechanical behavior of aggregated silica aerogels by investigating their microstructural connectivity and densification mechanisms under uniaxial compression. The interparticle connectivity is generated using the diffusion‐limited cluster–cluster aggregation (DLCA) algorithm, and the particle connections are modeled by beam elements that account for contact interaction. The mechanical response of representative volume elements (RVEs) is analyzed in both linear and nonlinear regimes while applying periodic boundary conditions. The model is correlated with experimental compression test data to validate the simulation results. With increasing compressive strain, load transitions between multiple backbone paths appear in the network structure. Thus, the simulation model provides insight into the compression process. Moreover, the simulation model enables the examination of the influence of various model parameters and facilitates the evaluation of the power–law relationship between the elasticity modulus and porosity of aerogels.
Clinical decision support to enhance venous thromboembolism pharmacoprophylaxis prescribing for pediatric inpatients with COVID‐19
Authors: Yan Adam Paul , Parsons Chase , Caplan Gregory , Kelly Daniel P. , Duzan Julie , Drake Emily , Kumar Riten 
Published: January 2024

AbstractObjectiveTo design and evaluate a clinical decision support (CDS) module to improve guideline concordant venous thromboembolism (VTE) pharmacoprophylaxis prescribing for pediatric inpatients with COVID‐19.Materials and methodsThe proportion of patients who met our institutional clinical practice guideline's (CPG) criteria for VTE prophylaxis was compared to those who triggered a CDS alert, indicating the patient needed VTE prophylaxis, and to those who were prescribed prophylaxis pre and post the launch of a new VTE CDS module to support VTE pharmacoprophylaxis prescribing. The sensitivity, specificity, positive predictive value (PPV), negative predictive value, F1‐score and accuracy of the tool were calculated for the pre‐ and post‐intervention periods using the CPG recommendation as the gold standard. Accuracy was defined as the sum of the true positives and true negatives over the sum of the true positives, false positives, true negatives, and false negatives. Logistic regression was used to identify variables associated with correct thromboprophylaxis prescribing.ResultsA significant increase in the proportion of patients triggering a CDS alert occurred in the post‐intervention period (44.3% vs. 6.9%, p < .001); however, no reciprocal increase in VTE prophylaxis prescribing was achieved (36.6% vs. 40.9%, p = .53). The updated CDS module had an improved sensitivity (55.0% vs. 13.3%), NPV (44.9% vs. 36.3%), F1‐score (66.7% vs. 23.5%), and accuracy (62.5% vs. 42.0%), but an inferior specificity (78.6% vs. 100%) and PPV (84.6% vs. 100%).DiscussionThe updated CDS model had an improved accuracy and overall performance in correctly identifying patients requiring VTE prophylaxis. Despite an increase in correct patient identification by the CDS module, the proportion of patients receiving appropriate pharmacologic prophylaxis did not change.ConclusionCDS tools to support correct VTE prophylaxis prescribing need ongoing refinement and validation to maximize clinical utility.
Predicting damage behaviors of composite laminates under multiple low‐velocity impacts
Authors: Lyu Qihui , Wang Ben , Zhao Zhenqiang , Bai Risheng , Guo Zaoyang , Wang Biao 
Published: January 2024

AbstractIn present investigation, experimental and numerical approaches were combined to investigate the distance between impact positions (DBIP) effects upon impact response and damage accumulation regarding carbon/glass hybrid laminates with multiple low‐velocity impacts. Force/energy‐time curves as well as force‐displacement curves with respect to the laminates with three various impact energies at four different impact positions were obtained from experiment data. Then C‐scans were made to quantify the damage of all the impacted specimens. Additionally, an integrated multi‐impact model was created considering both interlaminar delamination and intralaminar damage. Continuum damage mechanics model (CDM) was developed to calculate the impact resistance regarding laminates under various impact loadings with high efficiency. The simulation and experimental results agreed well. Moreover, the qualitative effects of impact positions on the laminates' mechanical responses were summarized utilizing predictive model that validated.Highlights
The effect of the DBIP on the impact response and damage accumulation of carbon/glass hybrid laminates subjected to multiple low‐velocity impacts was studied.
An integrated multi‐impact model was developed to predict the impact resistance of laminates under various impact loadings with high efficiency.
The qualitative effects of impact positions on the laminates' mechanical responses were summarized using a validated predictive model.
Improving the stability of multiwalled carbon nanotube/silicone rubber composites strain sensors by nanosilica
Authors: Wan Bangwei , Yang Yang , Zhao Yanfang 
Published: January 2024

AbstractConductive polymer composites use elastomers as a matrix for strain sensors. However, elastic polymer composites usually exhibit shoulder peak effects in their resistance response signals, limiting their applicability as strain sensors. In this study, we modified multiwalled carbon nanotubes (MWCNTs)/methyl vinyl silicone rubber (VMQ) by incorporating nanosilica (NSD) to eliminate the shoulder peak effect. The results showed that the addition of a suitable amount of NSD can improve the reconstruction of the conductive network of composite material and eliminated the shoulder peak effect of the composite material in the resistive response signal. The mechanism of eliminating the shoulder peak effect was elucidated, while the mechanical properties of the composite material were improved, which endowed the composite material with excellent strain sensing properties, including sensitivity (GF = 127) and response time (270 ms), and maintained excellent stability and recovery even in 15,000 cycles. These findings highlight the potential of our strain sensor for the real‐time strain monitoring of large‐deformation isolation bearings.Highlights
NSD eliminates shoulder peak effect in MWCNT/VMQ composites.
Explained the shoulder peak effect elimination mechanism.
NSD enhanced mechanical properties of MWCNT/VMQ composites.
MWCNT‐NSD20/VMQ composites have stable resistive strain response properties.
In‐utero evaluation of the fetal umbilical–portal venous system among fetuses with persistent right umbilical vein: Two‐and three‐dimensional ultrasonographic study
Authors: Massarwa Abeer , Weissbach Tal , Hadi Efrat , YuLzari Vered , Messing Baruch , Adamo Laura , Elkan‐Miller Tal , Achiron Reuven , Kivilevich Zvi , Bart Yossi , Weisz Boaz , Yoeli‐Ullman Rakefet , Mazaki Shali , Kassif Eran 
Published: January 2024

AbstractObjectiveThe aim of this study was to describe the anatomy of the portal system in fetuses with persistent right umbilical vein (PRUV).MethodsProspective observational study of fetuses diagnosed with PRUV. All patients underwent a comprehensive portal system anatomy scan supplemented by two‐dimensional (2D) and three‐dimensional (3D) color doppler modalities.Results29 fetuses with PRUV were studied. We perceived an identical anatomical pattern in 28 fetuses. The right umbilical vein drains to the portal sinus (future right portal vein, RPV), which has a configuration of a left portal vein (LPV) in the normal left portal system, with three emerging branches: inferior (RPVi), medial (RPVm) and superior (RPVs). The RPV then courses to the left, towards the stomach to the point of the bifurcation of the main portal vein (MPV) to become the left portal vein. The LPV has an RPV configuration in a normal portal system with anterior (LPVa) and posterior (RPVp) branches. This anatomical layout mimics a mirror image of the normal anatomy of left portal system.ConclusionPRUV has unique umbilical portal venous anatomy, which is a mirror image of the normal left portal system. It can be demonstrated prenatally and serve as an additional tool for prenatal diagnosis of PRUV.
Fabrication of a packaging film based on PLA blends: The evolution of physical, mechanical, and rheological properties
Authors: Attari Kia , Molla‐Abbasi Payam , Rashidzadeh Bahaaldin 
Published: January 2024

AbstractToday, the use of biodegradable polymers has become widespread in a wide range of industries. This research scrutinized the physical, mechanical, and rheological properties of poly (lactic acid)/poly (ethylene oxide)/carbon nanotube (PLA/PEO/CNTs) blend nanocomposites, as a good candidate for usage in the packaging industry. PEO and CNTs were added at various concentrations to improve the flexibility, toughness, gas permeability, thermal stability, and mechanical properties of PLA via solution blending. Differential scanning calorimetry (DSC), thermogravimetric analysis (TGA), Field Emission Scanning Electron Microscope (FESEM), water contact angle (WCA), rheometric mechanical spectrometer (RMS) test, gas permeability, and tensile characterization were performed to characterize the properties of the prepared blends and nanocomposites. The experimental results revealed that the addition of 25 wt% PEO to the PLA matrix made a partially miscible blend with a droplet‐matrix morphology. PEO at this concentration increased the elongation at break (from 2.2% to 18%) while reducing the modulus (from 25 to 6 MPa). Also, the experimental results indicated that the miscibility of PLA and PEO was enhanced by the addition of 1 wt% CNTs to the prepared blend, associated with diminished entropy of mixing in the LCST phase diagram. Theoretical calculations predicted that the CNTs would be localized in the PLA phase which increased the total crystallinity of the sample by 28%, considerably reducing the amount of gas permeation into the nanocomposite. In addition, the introduction of the CNTs to the blend increased the elongation at break and tensile strength by 13% compared to pure PLA and lowered the rate of thermal degradation effectively. Also, the final results showed that the COOH‐CNTs located in the PEO phase caused a decline in the crystallinity and an increase in the gas permeability of the prepared nanocomposite.Highlights
Improvement of physical properties of PLA by blending with PEO and CNTs.
A deep investigation on rheological behavior of the prepared nanocomposite.
Increasing the crystallinity degree of PLA/PEO blend by adding CNTs.
Improvement of the miscibility between PLA and PEO in the presence of CNTs.
Controlling the CNTs localization by surface modification.
Registration of ‘Tamrun OL18L’ and ‘Tamrun OL19’ peanut
Authors: Burow Mark D. , Baring Michael R. , Chagoya Jennifer , Simpson Charles E. , Cason John M. , López Yolanda 
Published: January 2024

Abstract‘Tamrun OL18L’ (Reg. no. CV‐155, PI 703068) and ‘Tamrun OL19’ (Reg. no. CV‐156, PI 703069) are high‐yielding, high oleic, early‐maturing runner‐type peanut (Arachis hypogaea L. subsp. hypogaea) cultivars. Tamrun OL18L was derived from a cross between a high oleic runner cultivar, ‘Tamrun OL02’, and TxL017746, an early runner breeding line selection developed from a cross between PI 109839 and ‘Florunner’. Tamrun OL19 was derived from a cross between a high oleic runner cultivar, ‘Tamrun OL01’, and TxL017746. Maturity of Tamrun OL18L was similar to ‘Tamrun OL12’, approximately 2 weeks earlier than ‘Tamrun OL07’. Tamrun OL19 matured approximately 1 week earlier than Tamrun OL07 and 1 week later than Tamrun OL12. Grades of Tamrun OL18L and Tamrun OL19 were similar, intermediate numerically between but not statistically different from Tamrun OL07 and Tamrun OL12; by comparison, Tamrun OL12 had a significantly lower grade than Tamrun OL07. Grades of Tamrun OL18L and Tamrun OL19 were lower than ‘Tamrun OL11’ but were similar to ‘Georgia‐09B’, ‘FloRun 107,’ and ‘TUFRunner 511.’ Yields were similar to Georgia‐09B, FloRun 107, and TUFRunner 511 but were higher than ‘Tamnut OL06’ and Tamrun OL11. Tamrun OL18L had a larger seed than most cultivars tested, significantly larger than Tamrun OL12 and Tamnut OL06, but was similar in size to Tamrun OL07 and ‘Webb’. No differences in flavor were noted between Tamrun OL18L, Tamrun OL19, and check cultivars.
Analysis of N‐ and O‐linked site‐specific glycosylation by ion mobility mass spectrometry: State of the art and future directions
Authors: Girgis Michael , Petruncio Gregory , Russo Paul , Peyton Steven , Paige Mikell , Campos Diana , Sanda Miloslav 
Published: January 2024

AbstractGlycosylation, the major post‐translational modification of proteins, significantly increases the diversity of proteoforms. Glycans are involved in a variety of pivotal structural and functional roles of proteins, and changes in glycosylation are profoundly connected to the progression of numerous diseases. Mass spectrometry (MS) has emerged as the gold standard for glycan and glycopeptide analysis because of its high sensitivity and the wealth of fragmentation information that can be obtained. Various separation techniques have been employed to resolve glycan and glycopeptide isomers at the front end of the MS. However, differentiating structures of isobaric and isomeric glycopeptides constitutes a challenge in MS‐based characterization. Many reports described the use of various ion mobility–mass spectrometry (IM–MS) techniques for glycomic analyses. Nevertheless, very few studies have focused on N‐ and O‐linked site‐specific glycopeptidomic analysis. Unlike glycomics, glycoproteomics presents a multitude of inherent challenges in microheterogeneity, which are further exacerbated by the lack of dedicated bioinformatics tools. In this review, we cover recent advances made towards the growing field of site‐specific glycosylation analysis using IM–MS with a specific emphasis on the MS techniques and capabilities in resolving isomeric peptidoglycan structures. Furthermore, we discuss commonly used software that supports IM–MS data analysis of glycopeptides.
3,5‐dinitro‐N2,N6‐bis(2,4,6‐trinitrophenyl)pyrazine‐2,6‐diamine (ZXC‐71): Thermally stable explosives with outstanding properties
Authors: Zhang Xingcheng , Li Yanyan , Lu Sitong , Xi Aoqi , Zhou Qiuju , Chen Luyao 
Published: January 2024

AbstractSingle‐compound heat‐resistant explosives are an important class of high‐energy compounds with excellent thermal stability. In this paper, a novel thermally stable explosive 3,5‐dinitro‐N2,N6‐bis(2,4,6‐trinitrophenyl)pyrazine‐2,6‐diamine (ZXC‐71) is reported. The commercially available 2,6‐dichloropyrazine was used as raw materials to prepare this compound with a straightforward method. The crystalline structure of ZXC‐71 was determined by single‐crystal X‐ray diffraction. From the calculated standard molar enthalpy of formation and the measured density, the Chapman–Jouguet detonation properties were predicted. The detonation velocity (D), detonation pressure (P), and density (ρ) of ZXC‐71 are 8608 m s−1, 29.8 GPa, and 1.86 g cm−3, respectively. ZXC‐71 also exhibits remarkable impact sensitivity (FS=22 J).
Is pitolisant safe for clinical use? A retrospective pharmacovigilance study focus on the post‐marketing safety
Authors: Jiang Cheng , Qian Jiancheng , Jiang Xin , Zhang Shuohan , Zheng Junxian , Wang Hongwei 
Published: January 2024

AbstractPitolisant, a novel histamine H3‐receptor antagonist, holds significant promise for treating narcolepsy. However, a petition, which highlighted that pitolisant was associated with deaths during clinical trials, has propelled it into the spotlight of widespread societal attention on April 3, 2023. Till now, the clinical safety of pitolisant remains a heatedly debated topic. This study aimed to offer a comprehensive assessment of the safety profile of pitolisant in real‐world clinical settings. Adverse event reports where pitolisant was the primary suspect drug were extracted from the FDA Adverse Event Reporting System database. The clinical characteristics and concomitant drugs of the pitolisant‐associated adverse events were analyzed. The potential adverse event signals of pitolisant were explored using four disproportionality analysis methods. Furthermore, the difference in pitolisant‐associated adverse event signals was investigated concerning sex, age, weight, and dose. A total of 526 reports and 1695 adverse events with pitolisant as the primary suspected drug were identified. The most significant adverse event signals were generally mild and of short duration. The concomitant drugs of pitolisant were highly intricate, mainly included drugs for treating narcolepsy as well as antidepressants. Seven new significant adverse event signals emerged. The safety profile of pitolisant exhibited no significant differences across age and dose groups, although slight variations were observed in relation to sex and weight. The findings from reports of death and life‐threatening outcomes underscore the importance of enhanced monitoring for cardiac and respiratory adverse reactions when utilizing pitolisant. This study provided a broader understanding of the safety profile of pitolisant.
A time‐varying meshing stiffness model for gears with mixed elastohydrodynamic lubrication based on load‐sharing
Authors: Gu Yingkui , Chen Ronghua , Qiu Guangqi , Huang Peng 
Published: January 2024

AbstractIn mixed elastohydrodynamic lubrication (EHL), the load distribution between the gear meshing surfaces is shared by the oil film and the asperities of the gear's rough surface. Based on the load‐sharing concept, this paper proposes a time‐varying meshing stiffness (TVMS) model for gears with mixed EHL. The initial step involves the utilization of the Greenwood‐Williamson model to calculate the contact stiffness of surface asperities, while the lubricating film is assessed using a curve‐fitting formula to investigate the influence of gear surface morphology on TVMS. Subsequently, the incorporation of gear fillet foundation deformation and friction enables accurate TVMS determination. The proposed method is employed to examine the meshing stiffness of the gear pair under both dry lubrication and EHL conditions. Comparative analysis reveals favorable agreement between the proposed model and experimental results obtained under dry lubrication, thereby highlighting the superior performance of the proposed approach. Moreover, the time‐varying friction coefficient under EHL is computed, and the impacts of gear surface morphology parameters, temperature, speed, and load on lubrication conditions and TVMS are investigated. The findings presented in this paper contribute significantly to advancements in gear design and performance.
Some novel neighborhood degree sum‐based versus degree‐based topological indices in QSPR analysis of alkanes from n‐butane to nonanes
Authors: Chamua Monjit , Buragohain Jibonjyoti , Bharali A. 
Published: January 2024

AbstractThe topological indices are reported to be very useful in various QSPR studies as these indices can be utilized as a tool to predict the physicochemical properties of a diverse set of chemical compounds. The objective of this communication is twofold. First, to introduce some neighborhood degree sum‐based topological indices and perform a comparative QSPR analysis of the indices with their corresponding degree‐based topological indices to analyze the usefulness of the new indices. Second, to investigate isomer discrimination ability of the newly defined indices on the basis of degeneracy test. Neighborhood degree sum‐based topological indices not only consider the degree of each atom in the molecule but also the degrees of its neighboring atoms. Moreover, these indices are expected to provide information about how connected and dense the neighborhoods of atoms are within the molecule. In this study, we observe that the proposed neighborhood degree sum‐based topological indices exhibit better correlation with some physicochemical properties of Octane Isomers and 66 alkanes as compared to their corresponding degree‐based topological indices. Also, the supremacy in terms of sensitivity of the neighbourhood degree sum‐based topological indices as compared to the classical degree‐based ones is established.