bluuebunny/crossref_metadata_2025_split huggingface dataset:
The Investigation of Bone-Implant Connection and New Bone Formation in Fasting and High-Fatty Diet Rats
Authors: Yavuz MC , Guler R , Ozcan EC , Bozoglan A , Kirtay M , Kaya CA , Dundar S 
Published: February 2024

ABSTRACT

Background:
Hyperlipidemia caused by a high-fat diet (HFD) has many adverse effects on the cardiovascular system, including vascular problems. In addition, a HFD also has significant adverse effects on bone health.

Aim:
The aim of this study is to examine bone-implant osteointegration and new bone formation in peri-implant defects in fasting and high-fatty diet applied rats.

Materials and Methods:
In this study, 28 female Sprague Dawley rats were used. The rats were divided into four groups, with seven rats in each group: the control group on a normal diet (Group 1) (n = 7), the fasted group (Group 2) (n = 7), the high-fatty diet (HFD) group (Group 3) (n = 7), and the fasted and HFD group (Group 4) (n = 7). Titanium implants with a diameter of 2.5 mm and a length of 4 mm were placed in the right tibia bones of the subjects, and a bone graft corresponding to 2 mm of the implant length was placed in the bone defect applied to the neck region. All rats that continued the administered diet for 12 weeks were sacrificed at the end of the experiment period. The implants and surrounding bone tissue were surgically removed and subjected to biomechanical analysis to assess bone-implant osteointegration and peri-implant new bone formation.

Results:
It was determined that there was no statistically significant difference between the rats in the control group and the other three groups in terms of bone-implant osteointegration and peri-implant new bone formation (P > 0.05).

Conclusion:
As a result of this study, it was determined that fasting or maintaining a HFD does not adversely affect bone-implant osteointegration or peri-implant new bone formation in the tibias of rats.
Perceptions of the COVID-19 Vaccine and Willingness to Receive Vaccination among Health Workers in Nigeria: A Cross-sectional Study
Authors: Isiguzo GC , Stefanovics E , Unamba NN , Mbam TT , Anyaehie UG , Chukwu CC , Anyaehie UB , Osy-Eneze C , Ibezim EO , Okoro UG , Njoku PO , Adimekwe AI , Ibediro K , Stefanovics G , Iheanacho T 
Published: February 2024

ABSTRACT

Background:
COVID-19 vaccine hesitancy is a major barrier to vaccine uptake, and the achievement of herd immunity is required to reduce morbidity and mortality and protect the most vulnerable populations. In Nigeria, COVID-19 vaccine hesitancy has been high, and uptake remains very low. Healthcare workers (HCWs) in Nigeria can help support public health efforts to increase vaccine uptake.

Aim:
This study evaluates Nigerian HCWs’ acceptance and intent to recommend the COVID-19 vaccine.

Subjects and Methods:
Cross-sectional survey among 1,852 HCWs in primary, secondary, and tertiary care settings across Nigeria. Respondents included doctors, nurses, pharmacy workers, and clinical laboratory professionals who have direct clinical contact with patients in various healthcare settings. A 33-item questionnaire was used in the study, with two of the questions focused on the COVID-19 vaccine. The responses to the two questions were analyzed using Chi-square (c2) tests and independent t-tests to determine the acceptance of the vaccine.

Results:
The majority of respondents were younger than 34 years (n = 1,227; 69.2%) and primarily worked in hospitals (n = 1,278; 72.0%). Among the respondents, 79.2% (n = 1,467) endorsed the COVID-19 vaccine as a critical tool in reducing the impact of the disease, and 76.2% (n = 1,412) will accept and recommend the vaccine to their patients. The younger HCWs were more likely to endorse and recommend the vaccine to their patients.

Conclusion:
There is a moderately high COVID-19 vaccine acceptance rate among HCWs surveyed in our study. The confidence of HCWs in its use and their willingness to recommend it to their patients can provide a potentially useful element in increasing acceptance by the larger population in Nigeria.
Modelling and Simulation of Grid Connected Wind Turbine Induction Generator for Windfarm
Authors: Rathinavel A , Ramya R 
Published: February 2024

As the power generation sector moving towards the sustainability to achieve clean and renewable energy source, the wind power generation plays a vital role due to its abundance in nature. A big chunk of the decrease in carbon emission is a major attribute to the growth of the wind energy sector. Wind turbine production, structural development, logistics, maintenance and R&D are just some of the areas that could benefit from the growth of the wind energy industry. This brought out the attention of researchers of the electrical engineering to focus on wind power generation. It can be more efficient and cost-effective to operate wind turbines as a wind farm rather than individually. This has led to a surge in the construction of wind farms, both onshore and offshore wind farms. Therefore, in this paper, the study and analyse of single Induction generator with wind turbines and 33MW windfarm performance is presented. The simulation result demonstrates the efficiency of DFIG in producing energy at a constant wind speed, as well as its ability to regulate both active and reactive power at steady-state.
Outreach Training and Supportive Supervision for Quality Malaria Service Delivery: A Qualitative Evaluation in 11 Sub-Saharan African Countries
Authors: Altaras Robin , Worges Matt , La Torre Sabrina , Audu Bala M. , Mwangi Grace , Zeh-Meka Albert , Yikpotey Paul , Domkam Kammogne Irenee , Chanda-Kapata Pascalina , Vanderick Caroline , Yukich Joshua , Streat Elizabeth 
Published: February 2024

ABSTRACT.
Quality improvement of malaria services aims to ensure that more patients receive accurate diagnosis, appropriate treatment, and referral. The Outreach Training and Supportive Supervision
Plus (OTSS+) approach seeks to improve health facility readiness and provider competency through onsite supportive supervision, troubleshooting, and on-the-job training. As part of a multicomponent evaluation, qualitative research was conducted to understand the value of the OTSS+ approach for malaria quality improvement. Semistructured key informant interviews, focus group discussions, and structured health facility–based interviews were used to gather stakeholder perspectives at subnational, national, and global levels. Data were collected globally and in 11 countries implementing OTSS+; in-depth data collection was done in four: Cameroon, Ghana, Niger, and Zambia. Study sites and participants were selected purposively. Verbatim transcripts were analyzed thematically, following the Framework approach. A total of 262 participants were included in the analysis; 98 (37.4%) were supervisees, 99 (37.8%) were supervisors, and 65 (24.8%) were other stakeholders. The OTSS+ approach was perceived to improve provider knowledge and skills in malaria service delivery and to improve data and supply management indirectly. Improvements were attributed to a combination of factors. Participants valued the relevance, adaptation, and digitization of supervision checklists; the quality and amount of contact with problem-solving supervisors; and the joint identification of problems and solutions, and development of action plans. Opportunities for improvement were digitized checklist refinement, assurance of a sufficient pool of supervisors, prioritization of health facilities, action plan dissemination and follow-up, and data review and use. The OTSS+ approach was perceived to be a useful quality improvement approach for malaria services.
Administration of combined exogenous L-arginine and ascorbic acid attenuates potassium bromate-induced renal and hepatic toxicity
Authors: Kolawole O.T. , Bakare S.O. , Ayankunle A.A. , Adeyeba O.A. 
Published: February 2024

Background: The use of potassium bromate (KBrO3) as food additive is still widespread and there is need to search for agents with protective effect against KBrO3-induced toxicity.
Objective: In this study, the protective effects of L-arginine, ascorbic acid, and their combined regimen on KBrO3-induced renal and hepatic toxicity were investigated in Wistar rats.
Methods: Five groups of male rats were used for the study. Group A was given distilled water (control), and group B was treated with KBrO3 only. In addition to KBrO3, groups C, D, and E were given L-arginine, ascorbic acid, and combined L-arginine and ascorbic acid respectively. After 28-day treatment, blood samples were taken for biochemical analysis; liver and kidney were harvested for histological examination.
Results: KBrO3 significantly (p < 0.05) raised serum levels of creatinine, urea, ALT, and AST compared to distilled water-treated control. Levels of SOD, CAT, and GPx were also significantly reduced. No significant changes in these parameters were observed with ascorbic acid and L-arginine given separately. Treatment with combined regimen of L-arginine and ascorbic acid resulted in significant (p < 0.05) reduction in the serum levels of creatinine, AST and ALT, and significant increase in the serum levels of SOD, CAT and GPx compared to the control. The distortions induced by KBrO3 in the structural architecture of renal and hepatic tissues were largely reduced in rats treated with combined ascorbic acid and L-arginine.
Conclusion: The study showed that L-arginine and ascorbic acid synergistically attenuate KBrO3-induced renal and hepatic toxicity.
Knowledge and treatment seeking behaviour for malaria among some undergraduate students of the University of Jos
Authors: Jimam N. S. , Oyeniyi V. L. , Dangiwa D. A. , Udezi A. W. , Lomak P. A. , Okunlola R. C. 
Published: February 2024

Background: Malaria remains a major public health problem in Nigeria. Information on clients’ knowledge and treatment seeking behaviour might improve or sustain the rational management of the disease and treatment outcome.
Objectives: This study assessed the knowledge and treatment seeking behaviour for the disease among undergraduate students of two Faculties of the University of Jos.
Materials and Method: The study employed a cross-sectional strategy in which a self-administered questionnaire was administered to two hundred and two (202) four hundred (400) and five hundred (500) levels Veterinary Medicine and Pharmaceutical sciences Faculty students of the University. The collected data was analyzed using IBM-SPSS® version 23 software.
Results: The total possible maximum correct knowledge score of the respondents was 10, and there mean (± SD) knowledge score was 7.77 (± 1.27), with majority (59.9%) having good knowledge of malaria and its management. Most of them either had moderate (38.1%) or good (36.1%) treatment seeking behaviour for the disease. Some factors including religion, level of education, patronage of healthcare facilities, and knowledge of the disease and its management were significant predictors of students’ treatment seeking behaviour for malaria.
Conclusion: Despite the fact that a high proportion of the students had good knowledge, their treatment seeking attitudes for the disease were not correspondingly high, implying the existence of a possible gap between the students’ theoretical knowledge on the disease and actual treatment seeking behaviour for the disease.
Epidemiological characteristics of hepatitis B and C in patients with inflammatory arthritis: Implications from treasure database
Authors: Duygu Ersözlü Emine , Ekici Mustafa , Nihan Coşkun Belkis , Özlem Badak Suade , Bilgin Emre , Kalyoncu Umut , Yağız Burcu , Pehlivan Yavuz , Küçükşahin Orhan , Erden Abdulsamet , Solmaz Dilek , Atagündüz Pamir , Kimyon Gezmiş , Beş Cemal , Çolak Seda , Mercan Rıdvan , Kaşifoğlu Timuçin , Emmungil Hakan , Alpay Kanıtez Nilüfer , Ateş Aşkın , Serdar Koca Süleyman , Kiraz Sedat , Ertenli İhsan 
Published: February 2024

Objectives: This study aimed to evaluate the hepatitis B (HBV) and C (HCV) frequency and clinical characteristics among patients with rheumatoid arthritis (RA) or spondyloarthritis (SpA) who receive biological treatments.
Patients and methods: The observational study was conducted with patients from the TReasure database, a web-based prospective observational registry collecting data from 17 centers across Türkiye, between December 2017 and June 2021. From this database, 3,147 RA patients (2,502 males, 645 females; median age 56 years; range, 44 to 64 years) and 6,071 SpA patients (2,709 males, 3,362 females; median age 43 years; range, 36 to 52 years) were analyzed in terms of viral hepatitis, patient characteristics, and treatments used.
Results: The screening rate for HBV was 97% in RA and 94.2% in SpA patients. Hepatitis B surface antigen (HBsAg) positivity rates were 2.6% and 2%, hepatitis B surface antibody positivity rates were 32.3% and 34%, hepatitis B core antibody positivity rates were 20.3% and 12.5%, HBV DNA (deoxyribonucleic acid) positivity rates were 3.5% and 12.5%, and antibody against HCV positivity rates were 0.8% and 0.3% in RA and SpA patients, respectively. The HBsAg-positive patients were older and had more comorbidities, including hypertension, diabetes, and coronary artery disease. In addition, rheumatoid factor (RF) positivity was more common in HBsAg-positive cases. The most frequently prescribed biologic disease-modifying antirheumatic drugs were adalimumab (28.5%), etanercept (27%), tofacitinib (23.4%), and tocilizumab (21.5%) in the RA group and adalimumab (48.1%), etanercept (31.4%), infliximab (22.6%), and certolizumab (21.1%) in the SpA group. Hepatitis B reactivation was observed in one RA patient during treatment, who received rituximab and prophylaxis with tenofovir.
Conclusion: The epidemiological characteristics of patients with rheumatic diseases and viral hepatitis are essential for effective patient management. This study provided the most recent epidemiological characteristics from the prospective TReasure database, one of the comprehensive registries in rheumatology practice.
Pregabalin inhibits proinflammatory cytokine release in patients with fibromyalgia syndrome
Authors: Ellergezen Pınar , Alp Alev , Çavun Sinan , Çelebi Melih , Ceren Macunluoğlu Aslı 
Published: February 2024

Objectives: The main goal of the study was to investigate how pregabalin (PGB) affects proinflammatory cytokine release in patients with fibromyalgia syndrome (FMS).
Patients and methods: This experimental research study was conducted with 85 female participants (mean age: 49.6±10.1 years; range, 30 to 73 years) between April 2020 and November 2020. Of the participants, 30 were FMS patients using PGB 150 mg/day for at least three months, 30 were FMS patients not using PGB, and 25 were healthy individuals. The detection of FMS was carried out according to the 2010 American College of Rheumatology diagnostic criteria. Levels of proinflammatory cytokines (interleukin [IL]-2, IL-6, IL-12, IL-17, interferon-gamma, and tumor necrosis factor-alpha) were measured by enzyme-linked immunosorbent assay.
Results: Serum concentrations of proinflammatory cytokines were remarkably decreased in FMS patients using PGB (p<0.001) and were higher in patients with FMS not using PGB than in healthy subjects (p<0.001). The highest values of proinflammatory cytokines were found in the group of FMS patients not using PGB (p<0.001).
Conclusion: These results indicate that PGB inhibits the release of proinflammatory cytokines, suggesting that it can be used as an anti-inflammatory agent in inflammatory cases.
Analysis of treatment outcomes in patients with antineutrophil cytoplasmic antibody-associated vasculitis on rituximab therapy
Authors: Yoneva Tsvetelina , Zdravkova Yana , Kotov Georgi , Ivanova Todorova Ekaterina , Vasilev Georgi , Rashkov Rasho , Sheytanov Ivan 
Published: February 2024

Objectives: This study aimed to analyze a group of patients with severe and refractory antineutrophil cytoplasmic antibody (ANCA)-associated vasculitis (AAV) managed with rituximab and to report on treatment outcomes.
Patients and methods: A total of 78 patients (41 females, 37 males; mean age: 50.1±13.4 years; range, 18 to 76 years) with AAV on rituximab treatment were included in the single-center, retrospective study conducted between 2009 and 2018. The diagnosis was established based on the 1990 classification criteria of the American College of Rheumatology and the definitions of vasculitis of Chapel Hill Consensus Conference. Laboratory and immunological tests were conducted. Disease activity was determined through the Birmingham Vasculitis Activity Score.
Results: Rituximab was preferred over cyclophosphamide in 37 patients and used as a second-line therapy after cyclophosphamide in 41 cases. Rituximab treatment showed favorable outcomes with regard to serum creatinine levels, proteinuria, and hematuria, as well as in cases of isolated lung involvement. Nearly half of patients with pulmonary renal syndrome also improved, with 22.2% achieving remission. ANCAs were positive in 85.9% of patients at the onset of rituximab treatment and became negative in 82% of the positive cases. Adverse events were rare and included infusion reactions (one case of reactivation of a herpes zoster infection and one case of allergic reaction).
Conclusion: Rituximab is an efficient and safe therapeutic option in patients with AAV who are difficult to treat, have insufficient response, or have not tolerated other treatments.
The role of ultrasonographic synovial assessment in rheumatoid arthritis patients with concomitant fibromyalgia
Authors: Polat Musa , Kahveci Abdulvahap , Tecer Duygu , Günendi Zafer , Göğüş Feride 
Published: February 2024

Objectives: This study aimed to compare the prevalence and musculoskeletal ultrasonography (US) findings of rheumatoid arthritis (RA) patients with concomitant fibromyalgia (FM) according to the 1990 American College of Rheumatology (ACR) FM classification criteria or the 2016 ACR FM diagnostic criteria.
Patients and methods: This cross-sectional study included 63 patients (17 males, 46 females; mean age: 48.2±7.1 years; range, 18 to 62 years) with RA. Medical history and laboratory data were obtained from electronic records. Clinical examination, composite disease activity measures, functional status, and the German 7-joint ultrasound score were assessed to evaluate disease activity and synovial inflammation. The patients were divided into three groups: patients who met only the 2016 ACR criteria, patients who met only the 1990 ACR criteria, and patients who met both criteria.
Results: In patients with RA, concomitant FM prevalence was 34.9% according to the 2016 ACR FM diagnostic criteria versus 23.8% according to the 1990 ACR FM classification criteria. Rheumatoid arthritis patients with FM had high tender joint count and disease activity scores, while musculoskeletal US findings were similar. Patients who met only the 2016 ACR FM diagnostic criteria had significantly higher gray-scale US and power Doppler US synovitis scores than patients who satisfied only ACR 1990 FM classification criteria (p=0.03 and p=0.02, respectively).
Conclusion: Synovial inflammation is a prominent sign in RA patients diagnosed with FM according to the 2016 ACR FM diagnostic criteria. The higher disease activity seen in the presence of FM in RA patients is associated with FM rather than synovitis.
Determinants of sleep disturbance and sleep quality in children of mothers with fibromyalgia
Authors: Fazilet Kartaloğlu Işıl , Karagül Sevil , Arslan Şule 
Published: February 2024

Objectives: This study aimed to determine whether maternal diagnosis of Fibromyalgia syndrome (FMS) affects the sleep quality of children.
Patients and methods: This prospective study was conducted with 80 female participants (mean age: 36.2±5.9 years; range 25 to 50 years) and their 80 children (27 males, 53 females; mean age: 6.6±2.6 years; range 2 to 12 years) between August 2019 and November 2020. The FMS group included 40 female FMS patients and their children, whereas the control group consisted of 40 healthy females and their children. In addition to sociodemographic variables, functional status was evaluated by the Fibromyalgia Impact Questionnaire (FIQ), which was completed by mothers with FMS, and the Children’s Sleep Habits Questionnaire (CSHQ) was used to evaluate the sleep quality of all children.
Results: There was no statistically significant difference between the two groups in terms of demographic characteristics (p>0.05). The CSHQ score of the two groups was above 41 points and was at a clinically significant level. The median value for the CSHQ score was 60.5 and 52 in the FMS and control groups, respectively. Sleep time, waking up at night, parasomnias, disrupted breathing during sleep, and sleepiness scores were higher in the FMS group than in the control group, and the differences were statistically significant (p<0.001). The delayed falling asleep score, which was reversely coded, was lower in the FMS group than in the control group, and the difference was statistically significant (p<0.001).
Conclusion: This pilot study showed that the children of mothers with high Fibromyalgia Impact Questionnaire scores had sleep disorders. Maternal diagnosis of FMS negatively affects the sleep quality of children.
industria del dato y su relevante impacto en la publicidad y en el derecho de la competencia
Authors: Navarro Ortega Asensio 
Published: February 2024

El trabajo expone los instrumentos de regulación, vigilancia y supervisión que se vienen desarrollando en Europa desde el año 2016 y en el marco de la Estrategia Europea de Datos, para dar respuesta a las necesidades y cambios tecnológicos que introduce la industria del dato en nuestra sociedad. Conforme a esta idea, se analiza el carácter competitivo del dato y cuándo la captación, explotación o almacenamiento de datos puede vulnerar la competencia al generar una posición dominante del mercado.
A través de ejemplos, se explica el funcionamiento de la economía de datos, las nuevas metodologías de análisis que deben aplicar las agencias reguladoras e independientes, el sistema de responsabilidad asimétrica que se viene conformando en relación con las grandes empresas tecnológicas, y, en general, el impacto que tiene el dato, como fenómeno disruptivo, en las relaciones económicas y jurídicas del conjunto de los usuarios, las pequeñas y medianas empresas y las Administraciones públicas.
Translation and validation of Indonesian hemorrhoidal disease symptom score (HDSS) and short health scale hemorrhoidal disease (SHSHD)
Authors: Robby Amsriza Fadli , Fakhriani Rizka , Aji Pangki Asmaya 
Published: February 2024

Objective: Hemorrhoidal disease, which affects nearly 40% of people, is characterized by pathological alterations and distal displacement of hemorrhoidal tissue. The short health scale (SHSHD) and the hemorrhoidal disease symptom score (HDSS) are two tools that can be utilized to assess the quality of life of hemorrhoidal patients. The present study aims to translate, modify, and validate the HDSS and SHSHD questionnaires in Indonesian.
Material and Methods: This cross-sectional study assessed the validity and reliability of the HDSS and SHSHD Indonesian adaptation instrument in hemorrhoidal patients from April 15, 2022, and April 1, 2023.
Results: There were 91 study subjects, 55 males and 36 females. The study showed that the subscale interpretations of the R-values and the full scale scored above 0.25, indicating weak to very strong correlations. These results mean that the HDSS and SHSHD questionnaires are valid for use. Based on the study’s results, the R-value of each item, domain, and total score ≥0.8 (p< 0.05) indicates that the HDSS and SHSHD instruments are reliable.
Conclusion: The Indonesian adaptation of the HDSS and SHSHD demonstrates validity and reliability as an assessment tool for measuring the healthrelated quality of life in Indonesian patients diagnosed with hemorrhoidal disease.