bluuebunny/crossref_metadata_2025_split huggingface dataset:
Thermoregulatory response in juvenile Hippocampus erectus: Effect of magnitude and rate of thermal increase on metabolism and antioxidative defence
Authors: Del Vecchio Giulia , Rodríguez‐Fuentes Gabriela , Rosas Carlos , Mascaró Maite 
Published: February 2024

AbstractBehavioural, physiological and biochemical mechanisms constitute the adaptive capacities that allow marine ectotherms to explore the environment beyond their thermal optimal. Limitations to the efficiency of these mechanisms define the transition from moderate to severe thermal stress, and serve to characterise the thermoregulatory response in the zone of thermal tolerance. We selected a tropical population of Hippocampus erectus to describe the timing of the physiological and biochemical mechanisms in response to the following increments in water temperature: (i) 4°C abrupt (26–30°C in <5 min); (ii) 7°C abrupt (26–33°C); (iii) 4°C gradual (1°C every 3 h) and (iv) 7°C gradual (1.5°C every 3 h). The routine metabolic rate (Rrout) of juvenile H. erectus was measured immediately before and after 0.5, 12 and 28 h of being exposed to each thermal treatment. Samples of muscle and abdominal organs were taken to quantify indicators of aerobic and anaerobic metabolism and antioxidant enzymes and oxidative stress at each moment throughout exposure. Results showed a full thermoregulatory response within 0.5 h: Rrout increased in direct correspondence with both the magnitude and rate of thermal increase; peroxidised lipids rapidly accumulated before the antioxidant defence was activated and early lactate concentrations suggested an immediate, yet temporary, reduction in aerobic scope. After 12 h, Rrout had decreased in sea horses exposed to 30°C, but not to 33°C, where Rrout continued high until the end of trials. Within 28 h of thermal exposure, all metabolite and antioxidant defence indicators had been restored to control levels (26°C). These findings testify to the outstanding thermal plasticity of H. erectus and explain their adjustment to rapid fluctuations in ambient temperature. Such features, however, do not protect this tropical population from the deleterious effects of chronic exposure to temperatures that have been predicted for the future.
Analysis of high‐frequency electromagnetic ringing phenomenon under GaN‐FET inverter excitation
Authors: Ogishima Norihiro , Thao Nguyen Gia Minh , Fujisaki Keisuke 
Published: February 2024

AbstractIn this study, the ringing phenomenon of gallium nitride‐field effect transistor (GaN‐FET) and silicon‐insulated gate bipolar transistor (Si‐IGBT) inverter excitations in a ring sample was thoroughly measured and analyzed by using a high‐quality oscilloscope with a very high sampling rate of 5 giga‐samples per second (GS/s). Owing to the rapid switching of the GaN‐FET power devices in several nanoseconds and the ringing frequencies in the MHz range, the use of the high sampling rate of 5 GS/s is necessary and useful for accurate measurement. The experimental findings and analysis reveal the following three key points: (i) there are two possible types of high‐frequency resonance phenomena, that is, the first one caused by semiconductor devices and circuits and the other generated by the resonance with loads in use. (ii) The ringing phenomenon because of the resonance under the load is considered to be due to the rising time of pulses that are caused by the rapid switching of the semiconductor devices. (iii) The ability to measure and the two types of ringing phenomena depends on the intensity of the white noise of the measuring instrument
Tricuspid regurgitation: Frequency, clinical presentation, management and outcome among patients with severe left‐sided valvular heart disease in Europe. Insights from the ESC‐EORP Valvular Heart Disease II survey
Authors: Dreyfus Julien , Komar Monika , Attias David , De Bonis Michele , Ruschitzka Frank , Popescu Bogdan A. , Laroche Cécile , Tribouilloy Christophe , Bogachev Prokophiev Alexander , Mizariene Vaida , Bax Jeroen J. , Maggioni Aldo Pietro , Messika‐Zeitoun David , Vahanian Alec , Iung Bernard ,   the EORP VHD II Registry Investigators Group
Published: February 2024

AbstractAimsTricuspid regurgitation (TR) is commonly observed in patients with severe left‐sided valvular heart disease (VHD). This study sought to assess TR frequency, management and outcome in this population.Methods and resultsAmong 6883 patients with severe native left‐sided VHD or previous left‐sided valvular intervention enrolled in the EURObservational Research Programme prospective VHD II survey, moderate or severe TR was very frequent in patients with severe mitral VHD (30% when mitral stenosis, 36% when mitral regurgitation [MR]), especially in patients with secondary MR (46%), and rare in patients with severe aortic VHD (4% when aortic stenosis, 3% when aortic regurgitation). An increase in TR grade was associated with a more severe clinical presentation and a poorer 6‐month survival (p < 0.0001). Rates of concomitant tricuspid valve (TV) intervention at the time of left‐sided heart valve surgery were high at the time of mitral valve surgery (50% when mitral stenosis, 41% when MR). Concordance between class I indications (patients with severe TR) for concomitant TV surgery at the time of left‐sided valvular heart surgery according to guidelines and real‐practice decision‐making was very good (88% overall, 95% in patients operated on for MR).ConclusionIn this large international prospective survey among patients with severe left‐sided VHD, moderate/severe TR was frequent in patients with mitral valve disease and was associated with a poorer outcome as TR grade increased. In patients with severe TR, compliance to guidelines for class I indications for concomitant TV surgery at the time of left‐sided heart valve surgery was very good.
The effect of nanocarbon inclusion on mechanical, tribological, and thermal properties of phenolic resin‐based composites: An overview
Authors: Adem Andarge Ayele , Panjiar Himanshu , Daniel Brainerd Samuel Sundar 
Published: February 2024

AbstractNanocarbons including carbon nanotubes, graphene oxide, reduced graphene oxide and particularly graphene have unique properties such as high mechanical strength, thermally stable, highly conducting, high friction stability and lower specific wear rates, which can potentially provide synergically improved performance of advanced engineering materials and technologies for various fields of applications such as automotive, aerospace, and other industrial components. Development of phenolic resin‐based nanocomposites comprised of nanocarbon material remained as a research focus to outperform different properties of conventional material based components. In application, phenolic resin is the most popular binder in frictional components development such as brake pads, brake linings, and clutch facings, particularly used in many of light and medium automotive brake pad applications. Specifically, the present review study aims to provide thorough discussion on the mechanical, tribological, and thermal performances of phenolic resin‐based nanocomposites containing nanocarbon as a property modifier by comparing with the neat phenolic resin or with the composite containing other micro ingredients. As per presented overview, the analysis shows the significant improvement in some required application‐based properties of phenolic resin‐based nanocomposites such as tensile strength, young's modulus, impact strength, specific wear rate reduction, residue yield, and thermal conductivity due to the inclusion of nanocarbon, where the content of nanocarbons ranges about 0.5 wt% to 5 wt%. Hence nanocomposites synthesized using phenolic resin matrix with nanocarbons fillers found to have better mechanical strength, better wear resistance, and thermal stabilities when compared to pure phenolic resin and other composites.
Tail risk forecasting with semiparametric regression models by incorporating overnight information
Authors: Chen Cathy W. S. , Koike Takaaki , Shau Wei‐Hsuan 
Published: February 2024

AbstractThis research incorporates realized volatility and overnight information into risk models, wherein the overnight return often contributes significantly to the total return volatility. Extending a semiparametric regression model based on asymmetric Laplace distribution, we propose a family of RES‐CAViaR‐oc models by adding overnight return and realized measures as a nowcasting technique for simultaneously forecasting Value‐at‐Risk (VaR) and expected shortfall (ES). We utilize Bayesian methods to estimate unknown parameters and forecast VaR and ES jointly for the proposed model family. We also conduct extensive backtests based on joint elicitability of the pair of VaR and ES during the out‐of‐sample period. Our empirical study on four international stock indices confirms that overnight return and realized volatility are vital in tail risk forecasting.
Chemical composition and antimicrobial activity of the essential oils in different populations of Coriandrum sativum L. (coriander) from Iran and Iraq
Authors: Talebi Seyed Mehdi , Naser Abbas , Ghorbanpour Mansour 
Published: February 2024

AbstractCoriander (Coriandrum sativum L.) is an annual herb belonging to the Apiaceae family that is grown worldwide. This aromatic herb has been used for its nutritional value and biological properties. In this study, we compared the essential oil composition and antibacterial activity of coriander seeds from nine Iranian and Iraqi populations for the first time. The seed oils were extracted using a Clevenger‐type apparatus, and their chemical composition was determined using GC and GC/MS Agilent apparatuses. The antimicrobial activity of the oils was tested against three infectious bacteria (Staphylococcus aureus, Escherichia coli, and Pseudomonas aeruginosa) using the agar well diffusion method. The experiments were repeated three times, and the results were analyzed using PAST, SAS, and SPSS software. The results showed that oxygenated monoterpenes, especially linalool, were the major compounds in the oils, followed by α‐pinene, γ‐terpinene, and geranyl acetate. The proportions of these compounds varied among the populations. Trace amounts of other compounds were also detected, some of which were only found in certain populations. The populations were detected as linalool chemotype, and classified into four groups based on their chemical constituents in the UPGMA tree. The PCA‐Biplot showed that these groups were characterized by the presence and percentage of specific compounds. The essential oils showed bacterial growth inhibitory properties only at 100% concentration. S. aureus was the most sensitive bacterium to the coriander essential oil, while the essential oils of all populations inhibited the growth of this bacterium. Additionally, the essential oils were more effective than antibiotics against E. coli. These findings contribute to our understanding of coriander seed essential oil by providing data on antibacterial activity and chemical characteristics. Furthermore, the study highlights the importance of selecting populations based on their specific essential oil profiles for antibacterial applications.
DCP: A pipeline toolbox for diffusion connectome
Authors: Huang Weijie , Dong Xinyi , Zhao Tengda , Kucikova Ludmila , Fu Anguo , Shu Ni 
Published: February 2024

AbstractThe brain structural network derived from diffusion magnetic resonance imaging (dMRI) reflects the white matter connections between brain regions, which can quantitatively describe the anatomical connection pattern of the entire brain. The development of structural brain connectome leads to the emergence of a large number of dMRI processing packages and network analysis toolboxes. However, the fully automated network analysis based on dMRI data remains challenging. In this study, we developed a cross‐platform MATLAB toolbox named “Diffusion Connectome Pipeline” (DCP) for automatically constructing brain structural networks and calculating topological attributes of the networks. The toolbox integrates a few developed packages, including FSL, Diffusion Toolkit, SPM, Camino, MRtrix3, and MRIcron. It can process raw dMRI data collected from any number of participants, and it is also compatible with preprocessed files from public datasets such as HCP and UK Biobank. Moreover, a friendly graphical user interface allows users to configure their processing pipeline without any programming. To prove the capacity and validity of the DCP, two tests were conducted with using DCP. The results showed that DCP can reproduce the findings in our previous studies. However, there are some limitations of DCP, such as relying on MATLAB and being unable to fixel‐based metrics weighted network. Despite these limitations, overall, the DCP software provides a standardized, fully automated computational workflow for white matter network construction and analysis, which is beneficial for advancing future human brain connectomics application research.
Novel mixed solar cooker: Experimental, energy, exergy, and economic analysis
Authors: Benbaha Assam , Yettou Fatiha , Azoui Boubakeur , Gama Amor , Rathore Neelam , Panwar Narayan Lal 
Published: February 2024

AbstractThis work focuses on the structure, working, and testing of a new mixed solar cooker using a linear Fresnel collector, evacuated tube and box‐type cooker. The low‐cost components used in the construction of this cooker can help it satisfy the needs of both urban and rural inhabitants who need steady cooking temperatures above 140°C. A family of five can prepare four meals using this modified solar cooker, which costs about $250. The designed solar cooker was tested by conducting no‐load and full‐load tests. For the no‐load test, the maximum temperature of the absorber plate and oil for the new mixed cooker was recorded as 160.26°C and 172.72°C, respectively. The absorber plate of the new mixed cooker and its oil both reached their highest temperatures during the full‐load test at 141.14°C and 157°C, respectively. The energy efficiency of the new cooker is 58.776%, while its exergy efficiency is 13%. The heat transfer coefficient increased to 100.16 W/m² °C. This cooker provides an additional time savings of 60 min. An improvement of 27.5% in the highest temperature reached was seen when the developed cooker's performance was compared with those reported in the literature. Additionally, the new cooker's heat‐storing capability enables up to 3 h of autonomy. The Levelized Cost of Cooking a Meal for the innovative mixed solar cooker is $0.034 per meal.
In situ polymerization of water‐induced 1,3‐phenylene diisocyanate for enhanced efficiency and stability of inverted perovskite solar cells
Authors: Jia Shiyao , Yang Jiabao , Wang Tong , Pu Xingyu , Chen Hui , He Xilai , Feng Guangpeng , Chen Xingyuan , Bai Yijun , Cao Qi , Li Xuanhua 
Published: February 2024

AbstractIn the realm of photovoltaics, organometallic hybridized perovskite solar cells (PSCs) stand out as promising contenders for achieving high‐efficiency photoelectric conversion, owing to their remarkable performance attributes. Nevertheless, defects within the perovskite layer, especially at the perovskite grain boundaries and surface, have a substantial impact on both the overall photoelectric performance and long‐term operational stability of PSCs. To mitigate this challenge, we propose a method for water‐induced condensation polymerization of small molecules involving the incorporation of 1,3‐phenylene diisocyanate (1,3‐PDI) into the perovskite film using an antisolvent technique. Subsequent to this step, the introduction of water triggers the polymerization of [P(1,3‐PDI)], thereby facilitating the in situ passivation of uncoordinated lead defects inherent in the perovskite film. This passivation process demonstrates a notable enhancement in both the efficiency and stability of PSCs. This approach has led to the attainment of a noteworthy power conversion efficiency (PCE) of 24.66% in inverted PSCs. Furthermore, based on the P(1,3‐PDI) modification, these devices maintain 90.15% of their initial efficiency after 5000 h of storage under ambient conditions of 25°C and 50 ± 5% relative humidity. Additionally, even after maximum power point tracking for 1000 h, the PSCs modified with P(1,3‐PDI) sustain 82.05% of the initial PCE. Small molecules can rationally manipulate water and turn harm into benefit, providing new directions and methods for improving the efficiency and stability of PSCs.
Clinical and genetic factors associated with tumor response to neoadjuvant (chemo)radiotherapy, survival and recurrence risk in rectal cancer
Authors: Hammarström Klara , Nunes Luís , Mathot Lucy , Mezheyeuski Artur , Lundin Emma , Korsavidou Hult Nafsika , Imam Israa , Osterlund Emerik , Sjöblom Tobias , Glimelius Bengt 
Published: February 2024

AbstractRectal cancer poses challenges in preoperative treatment response, with up to 30% achieving a complete response (CR). Personalized treatment relies on accurate identification of responders at diagnosis. This study aimed to unravel CR determinants, overall survival (OS), and time to recurrence (TTR) using clinical and targeted sequencing data. Analyzing 402 patients undergoing preoperative treatment, tumor stage, size, and treatment emerged as robust response predictors. CR rates were higher in smaller, early‐stage, and intensively treated tumors. Targeted sequencing analyzed 216 cases, while 120 patients provided hotspot mutation data. KRAS mutation dramatically reduced CR odds by over 50% (odds ratio [OR] = 0.3 in the targeted sequencing and OR = 0.4 hotspot cohorts, respectively). In contrast, SMAD4 and SYNE1 mutations were associated with higher CR rates (OR = 6.0 and 6.8, respectively). Favorable OS was linked to younger age, CR, and low baseline carcinoembryonic antigen levels. Notably, CR and an APC mutation increased TTR, while a BRAF mutation negatively affected TTR. Beyond tumor burden, SMAD4 and SYNE1 mutations significantly influenced CR. KRAS mutations independently correlated with radiotherapy resistance, and BRAF mutations heightened recurrence risk. Intriguingly, non‐responding tumors with initially small sizes carried a higher risk of recurrence. The findings, even if limited in addition to the imperfect clinical factors, offer insights into rectal cancer treatment response, guiding personalized therapeutic strategies. By uncovering factors impacting CR, OS, and TTR, this study underscores the importance of tailored approaches for rectal cancer patients. These findings, based on extensive analysis and mutation data, pave the way for personalized interventions, optimizing outcomes in the challenges of rectal cancer preoperative treatment.
The impact of the regulatory business environment on SMEs' funding choices in developing countries: Evidence from Africa
Authors: Hansen‐Addy Andrew E. , Parrilli Mario Davide , Tingbani Ishmael 
Published: February 2024

AbstractWhile it is known that some elements of the business environment (BE), such as macroeconomic conditions, impact access to finance and the funding choices of SMEs, very little is known whether other elements of the BE—such as the institutional setting and the regulatory business environment (RBE)—influence access to (or supply of) finance and the funding choices of SMEs. Using a World Bank Enterprise Surveys panel sample (2003–2020) from 30 African countries and employing Propensity Score Matching (PSM) methods, it is noted that while an enabling institutional setting and RBE in Africa increases access to external finance for SMEs, SMEs still opt for retained earnings over funding from banking and non‐banking financial institutions for their working capital. This funding behaviour can be explained by that SMEs located in enabling RBEs have increased productivity and financial performance and so can employ larger amounts of retained earnings for their operations. Furthermore, even though more accessible in enabling RBEs, external finance remains unaffordable for most SMEs in Africa. These findings indicate the need to tailor interventions to make varied finance more accessible and affordable for SMEs in developing countries.
Photoaffinity probe‐based antimalarial target identification of artemisinin in the intraerythrocytic developmental cycle of Plasmodium falciparum
Authors: Gao Peng , Wang Jianyou , Qiu Chong , Zhang Huimin , Wang Chen , Zhang Ying , Sun Peng , Chen Honglin , Wong Yin Kwan , Chen Jiayun , Zhang Junzhe , Tang Huan , Shi Qiaoli , Zhu Yongping , Shen Shengnan , Han Guang , Xu Chengchao , Dai Lingyun , Wang Jigang 
Published: February 2024

AbstractMalaria continues to pose a serious global health threat, and artemisinin remains the core drug for global malaria control. However, the situation of malaria resistance has become increasingly severe due to the emergence and spread of artemisinin resistance. In recent years, significant progress has been made in understanding the mechanism of action (MoA) of artemisinin. Prior research on the MoA of artemisinin mainly focused on covalently bound targets that are alkylated by artemisinin‐free radicals. However, less attention has been given to the reversible noncovalent binding targets, and there is a paucity of information regarding artemisinin targets at different life cycle stages of the parasite. In this study, we identified the protein targets of artemisinin at different stages of the parasite's intraerythrocytic developmental cycle using a photoaffinity probe. Our findings demonstrate that artemisinin interacts with parasite proteins in vivo through both covalent and noncovalent modes. Extensive mechanistic studies were then conducted by integrating target validation, phenotypic studies, and untargeted metabolomics. The results suggest that protein synthesis, glycolysis, and oxidative homeostasis are critically involved in the antimalarial activities of artemisinin. In summary, this study provides fresh insights into the mechanisms underlying artemisinin's antimalarial effects and its protein targets.
Epigenetic reprogramming in the transition from pluripotency to totipotency
Authors: Han Qingsheng , Ma Ru , Liu Na 
Published: February 2024

AbstractMammalian development commences with the zygote, which can differentiate into both embryonic and extraembryonic tissues, a capability known as totipotency. Only the zygote and embryos around zygotic genome activation (ZGA) (two‐cell embryo stage in mice and eight‐cell embryo in humans) are totipotent cells. Epigenetic modifications undergo extremely extensive changes during the acquisition of totipotency and subsequent development of differentiation. However, the underlying molecular mechanisms remain elusive. Recently, the discovery of mouse two‐cell embryo‐like cells, human eight‐cell embryo‐like cells, extended pluripotent stem cells and totipotent‐like stem cells with extra‐embryonic developmental potential has greatly expanded our understanding of totipotency. Experiments with these in vitro models have led to insights into epigenetic changes in the reprogramming of pluri‐to‐totipotency, which have informed the exploration of preimplantation development. In this review, we highlight the recent findings in understanding the mechanisms of epigenetic remodeling during totipotency capture, including RNA splicing, DNA methylation, chromatin configuration, histone modifications, and nuclear organization.