bluuebunny/crossref_metadata_2025_split huggingface dataset:
The Modified Myocardial Index for Evaluation of Fetal Cardiac Function in Gestational Diabetes Mellitus
Authors: OĞUZ Yüksel , ULUSOY Can Ozan , AĞAOĞLU Recep Taha , YAKUT YÜCEL Kadriye , YILMAZ Zehra 
Published: December 2023

Objectives
The modified myocardial performance index (Mod‐MPI) is a new technique that is used to assess myocardial function. Gestational Diabetes can affect myocardial function and may lead to change Mod –MPI value. We aimed to evaluate fetal cardiac function with Mod-MPI in pregnant with GDM and compare with healthy pregnant.
Material and Methods
Totally 60 pregnant; 30 with GDM and 30 without disease were included into this prospective case control study. Demographic characteristics of the study group were recorded. Mod-MPI and obstetric Doppler parameters were calculated for each fetus by an experienced perinatologist. The results of the two groups were compared.
Results
There was no difference in demographic characteristics terms of age, parity and BMI. The mean Mod-MPI value was found significantly higher in pregnant with GDM when compared with healthy pregnant. The obstetric Doppler parameters were found similar between groups.
Conclusion
The utility of the Mod‐MPI in GDM pregnant is unclear in literature. Future prospective studies with larger number of cases are needed to to evaluate the utility of the Mod‐MPI as a predictor of cardiac function in fetuses of GDM mothers.
Radiofrequency ablation of parathyroid gland as a treatment modality for primary hyperparathyroidism – A novel bedside procedure in critically ill patients
Authors: Shivashankariah Vikram Halkurke , Tiwari Dheeraj Kumar , Ramamurthy Madhusudan , Harinarayan C. V. , Krishnamurthy Deepak , Janardhan Raghu 
Published: December 2023

Abstract
Primary hyperparathyroidism caused by parathyroid adenoma is managed surgically so far. Radiofrequency ablation (RFA) of the parathyroid gland is a new modality which is gradually replacing open neck surgery. RFA is done as a bedside procedure in less than 30 min, with no scar, post-operative management, etc. In addition, it has a major advantage for patients who are not fit for anaesthesia, other comorbidities and critically ill patients. We report a case of parathyroid adenoma successfully ablated using radiofrequency in a critically ill patient with comorbidities.
18Fluorodeoxyglucose positron emission tomography-computed tomography findings in bilateral adrenal metastases in renal cell carcinoma
Authors: Sireesha Polisetty , Kalawat Tekchand C. , Ajit Nimmagadda , Hemalatha D. S. , Priya R. Ramya 
Published: December 2023

Abstract
Bilateral adrenal metastases is a rare manifestation which can be seen in malignancies such as breast, lung carcinoma and melanomas. Adrenal metastases are usually detected on one side or more rarely on both sides. Molecular imaging with 18fluorodeoxyglucose positron emission tomography-computed tomography often shows unilateral or bilateral adrenal metastases in various malignancies. Here, we present a case of renal cell carcinoma that presented with widespread skeletal and bilateral adrenal metastases.
Managing nasolabial cyst: Experience at a tertiary care teaching hospital in Eastern India
Authors: Swain Santosh Kumar , Dubey Debasmita 
Published: December 2023

Abstract

Background:
Nasolabial cysts are non-odontogenic cysts that arise from the nasal alar area. Sublabial resection of the nasolabial cyst is considered an effective surgical modality of treatment.

Objective:
This study aimed to evaluate the clinical presentation, diagnosis and treatment of nasolabial cyst at a tertiary care teaching hospital in eastern India.

Methods:
This was a retrospective study of 38 cases of nasolabial cysts managed between May 2018 and June 2022. The detailed clinical presentations, investigations and treatment of nasolabial cysts of the patients were studied.

Results:
Out of 38 cases of the nasolabial cyst, 22 (57.9%) were seen on the left side, 13 (34.2%) were seen on the right side and 3 were seen bilaterally. The most common presenting complaint was facial swelling (84.2%). Computed tomography of the nose and paranasal sinuses was done in 24/38 (70.5%) patients studied. Surgical excision of the nasolabial cysts was done by intraoral sublabial approach in 32 (84.2%) cases and 6 underwent endoscopic transnasal marsupialisation. The most common post-operative complication was post-operative facial/perinasal swelling. One case of recurrence was reported who underwent endoscopic transnasal marsupialisation.

Conclusions:
Nasolabial cysts are an uncommon clinical entity but manifest cosmetic deformity and nasal obstruction. Intraoral sublabial excision and endoscopic transnasal marsupialisation are important surgical techniques for the nasolabial cyst. The post-operative complications and chance of recurrence are rare.
Paroxysmal nocturnal haemoglobinuria presenting as cortical cerebral venous thrombosis
Authors: Nouduri Abhishek Venkata , Talasila Akshara Sai Sri , Shetty Mallikarjuna , Khaleelullah Syed , Srikanth Rama , Iyer Aishwarya 
Published: December 2023

Abstract
Paroxysmal nocturnal haemoglobinuria (PNH) arises as a consequence of mutation of phosphatidylinositol N-acetylglucosaminyltransferase subunit A gene that is required for synthesis of the glycosylphosphatidylinositol proteins to the cell surface of blood cells. Patients with PNH usually present with features of chronic unexplained anaemia, but can also present with bone marrow failure and thrombosis at unusual sites. We present the case of a 27-year-old who presented with complaints of headache and easy fatigability, on evaluation was found to have coombs negative haemolytic anaemia and brain magnetic resonance venogram revealed thrombosis in the left transverse and sigmoid sinuses. On further investigation, found to have PNH clone in both red and white blood cell lineages and diagnosed as PNH. Hence, any patient presenting with chronic non-immune intravascular haemolysis, unexplained anaemia and unusual thrombosis should alert the physician to consider PNH as a differential diagnosis to avoid delay in diagnosis and better management.
An unusual case of angioedema
Authors: Naini Abhilash , Sree Aakula Suguna , Talasila Akshara Sai Sri , Pappu Sai Subrahmanyam , Shetty Mallikarjuna 
Published: December 2023

Abstract
A 40-year-old female with diabetes mellitus and hypothyroidism presented with a 15 days history of itching all over the body associated with urticarial rash which resolved spontaneously and rapid-onset facial swelling and stiffness for 10 days with the inability to open eyelids due to swelling. On physical examination, the face was swollen diffusely with restriction of eye and mouth opening due to the swelling. In view of unresponsiveness to parenteral steroids and antihistamines, non-allergic causes of angioedema were suspected. Peripheral blood smear examination revealed 55% atypical cells. Bone marrow aspirate examination was suggestive of acute myeloid leukaemia with monocytic differentiation.
Extensive venous thrombosis – A rare presentation of ulcerative colitis in a young female
Authors: Durgam Ramya , Hussain Gundluru Zakeer , Harshitha Bonam , Raju Y. Sathyanarayana 
Published: December 2023

Abstract
Extraintestinal manifestations (EMs) are well recognised in association with ulcerative colitis (UC). Immunologically mediated and thrombotic events are uncommon manifestations of this disease. We present the case of a 28-year-old female with a 2-year history of loose stools presenting with bilateral lower limb oedema. On evaluation, extensive deep venous thrombosis of bilateral lower limbs extending to the inferior vena cava and acute on chronic pulmonary thromboembolism was evident. Laboratory evaluation demonstrated anaemia, leucocytosis, elevated C-reactive protein and erythrocyte sedimentation rate, positive perinuclear antinuclear cytoplasmic antibody, antinuclear antibody-immunofluorescence and stool for occult blood. Colonoscopy and histopathological examination of colonic mucosa were suggestive of inflammatory bowel disease favouring the diagnosis of UC. She was started on oral prednisolone 20 mg daily with brisk improvement in her anaemia. She was therapeutically anticoagulated for extensive venous thrombosis. She continued to deteriorate and developed severe respiratory distress and cardiogenic shock and was given mechanical ventilatory support. This case report reviews venous thrombosis as a rare extraintestinal complication of UC, including the presentation, diagnosis and treatment.
Paravertebral extramedullary haematopoiesis mimicking myeloid sarcoma
Authors: Debahuti Mohapatra , Das Prateek , Govardhan Tulasi , Kumar Bhola Rajesh 
Published: December 2023

Abstract
Extramedullary haematopoiesis (EMH) is the formation and development of blood cells outside the bone marrow. They are benign process associated with myeloproliferative disorders, haemolytic anaemia, hereditary spherocytosis and Gaucher’s disease. The common locations for EMH are reticuloendothelial system, namely liver, spleen and lymph node. However, other locations such as lung, urogenital system, retroperitoneum and mediastinum are rare sites of occurrence. A 50-year-old male, with sickle cell disease, presented with a history of dyspnoea and backache showing a bilateral mass in the paravertebral (thoracic) region, pleural thickening and small mass in the lung. The clinical diagnosis was lung neoplasm. The needle core biopsy was obtained from the paravertebral mass. Microscopy showed trilineage haemopoietic proliferation along with few fat cells. Thus, the diagnosis of EMH was made. Being a rare benign entity, EMH often mimics malignancy as well as granulocytic sarcoma which show the presence of acute or chronic leukaemia, presence of increased eosinophilic precursor and increased number of myeloblasts. Thus, the awareness of the entity as well as early diagnosis helps the patient in appropriate management of this benign yet rare entity.
Bleomycin for Intralesional Sclerotherapy of Haemangioma in the Oral Mucosa: Case Report and Mini Review of Literature
Authors: Nazar Jincy , Philip Rony Mukkoottil 
Published: December 2023

Abstract
Haemangiomas are benign congenital anomalies of the vascular system. Percutaneous sclerotherapy is used to treat vascular malformations, which can cause significant discomfort and/or disfigurement. In this article, we present the clinical case of a female patient diagnosed with a superficial capillary haemangioma of the gingiva at the age of adulthood, where two intralesional injections with a solution of bleomycin were performed at 1-month intervals between them, with very good aesthetic and functional results, only 3 months after starting therapy and the authors investigate the effectiveness and safety of bleomycin injections for vascular malformations regarding size reduction, symptom relief, quality of life, adverse events (including pulmonary fibrosis) and patient satisfaction.
Human mesenchymal stem cells exhibit altered mitochondrial dynamics and poor survival in high glucose microenvironment
Authors: Abu-El-Rub Ejlal , Almahasneh Fatimah , Khasawneh Ramada R , Alzu'bi Ayman , Ghorab Doaa , Almazari Rawan , Magableh Huthaifa , Sanajleh Ahmad , Shlool Haitham , Mazari Mohammad , Bader Noor S , Al-Momani Joud 
Published: December 2023

BACKGROUND
Mesenchymal stem cells (MSCs) are a type of stem cells that possess relevant regenerative abilities and can be used to treat many chronic diseases. Diabetes mellitus (DM) is a frequently diagnosed chronic disease characterized by hyperglycemia which initiates many multisystem complications in the long-run. DM patients can benefit from MSCs transplantation to curb down the pathological consequences associated with hyperglycemia persistence and restore the function of damaged tissues. MSCs therapeutic outcomes are found to last for short period of time and ultimately these regenerative cells are eradicated and died in DM disease model.
AIM
To investigate the impact of high glucose or hyperglycemia on the cellular and molecular characteristics of MSCs.
METHODS
Human adipose tissue-derived MSCs (hAD-MSCs) were seeded in low (5.6 mmol/L of glucose) and high glucose (25 mmol/L of glucose) for 7 d. Cytotoxicity, viability, mitochondrial dynamics, and apoptosis were deplored using specific kits. Western blotting was performed to measure the protein expression of phosphatidylinositol 3-kinase (PI3K), TSC1, and mammalian target of rapamycin (mTOR) in these cells.
RESULTS
hAD-MSCs cultured in high glucose for 7 d demonstrated marked decrease in their viability, as shown by a significant increase in lactate dehydrogenase (P < 0.01) and a significant decrease in Trypan blue (P < 0.05) in these cells compared to low glucose control. Mitochondrial membrane potential, indicated by tetramethylrhodamine ethyl ester (TMRE) fluorescence intensity, and nicotinamide adenine dinucleotide (NAD+)/NADH ratio were significantly dropped (P < 0.05 for TMRE and P < 0.01 for NAD+/NADH) in high glucose exposed hAD-MSCs, indicating disturbed mitochondrial function. PI3K protein expression significantly decreased in high glucose culture MSCs (P < 0.05 compared to low glucose) and it was coupled with significant upregulation in TSC1 (P < 0.05) and downregulation in mTOR protein expression (P < 0.05). Mitochondrial complexes I, IV, and V were downregulated profoundly in high glucose (P < 0.05 compared to low glucose). Apoptosis was induced as a result of mitochondrial impairment and explained the poor survival of MSCs in high glucose.
CONCLUSION
High glucose impaired the mitochondrial dynamics and regulatory proteins in hAD-MSCs ensuing their poor survival and high apoptosis rate in hyperglycemic microenvironment.
Serum omentin-1 is correlated with the severity of liver disease in patients with chronic hepatitis C
Authors: Peschel Georg , Weigand Kilian , Grimm Jonathan , Müller Martina , Buechler Christa 
Published: December 2023

BACKGROUND
Patients with chronic hepatitis C virus (HCV) infection have increased serum omentin-1. Omentin-1 is an anti-inflammatory adipokine, and higher levels may be a direct effect of HCV infection. Successful elimination of HCV by direct acting antivirals almost normalized circulating levels of various molecules with a role in inflammation.
AIM
To evaluate the effect of HCV infection on serum omentin-1, serum omentin-1 levels of HCV patients were measured before therapy and at 12 wk after therapy end. Associations of serum omentin-1 with parameters of inflammation and liver function were explored at both time points. Serum omentin-1 levels of patients with and without liver cirrhosis, which was defined by ultrasound or the fibrosis-4 (FIB-4) score, were compared.
METHODS
Serum omentin-1 levels were measured by enzyme-linked immunosorbent assay in 84 chronic HCV patients before therapy and at 12 wk after therapy end where sustained virological response 12 (SVR12) was achieved in all patients. Serum omentin-1 of 14 non-infected controls was measured in parallel.
RESULTS
In patients with chronic HCV, serum omentin-1 levels were not related to viral load or viral genotype. HCV patients with liver steatosis and HCV patients with diabetes had serum omentin-1 levels comparable to patients not suffering from these conditions. Serum omentin-1 levels at SVR12 were similar in comparison to pretreatment levels. In addition, serum levels did not differ between HCV-infected patients and non-infected controls. Serum omentin-1 levels did not correlate with leukocyte count or C-reactive protein. Positive correlations of serum omentin-1 with bilirubin and the model for end-stage liver disease score (MELD) were detected before therapy and at SVR12 in the whole cohort. Bilirubin and the MELD score also positively correlated with serum omentin-1 levels in the subgroup of patients with ultrasound diagnosed liver cirrhosis before therapy. At SVR12, serum omentin-1 levels of patients with liver cirrhosis negatively correlated with albumin. Before therapy start, patients with high FIB-4 scores had increased serum omentin-1 in comparison to patients with a low score. Serum omentin-1 levels of patients with liver cirrhosis defined by ultrasound were increased at baseline and at SVR12.
CONCLUSION
Present study showed that liver cirrhosis, but not HCV infection per se, is related to elevated serum omentin-1 levels.
Methods for improving colorectal cancer annotation efficiency for artificial intelligence-observer training
Authors: Grudza Matthew , Salinel Brandon , Zeien Sarah , Murphy Matthew , Adkins Jake , Jensen Corey T , Bay Curtis , Kodibagkar Vikram , Koo Phillip , Dragovich Tomislav , Choti Michael A , Kundranda Madappa , Syeda-Mahmood Tanveer , Wang Hong-Zhi , Chang John 
Published: December 2023

BACKGROUND
Missing occult cancer lesions accounts for the most diagnostic errors in retrospective radiology reviews as early cancer can be small or subtle, making the lesions difficult to detect. Second-observer is the most effective technique for reducing these events and can be economically implemented with the advent of artificial intelligence (AI).
AIM
To achieve appropriate AI model training, a large annotated dataset is necessary to train the AI models. Our goal in this research is to compare two methods for decreasing the annotation time to establish ground truth: Skip-slice annotation and AI-initiated annotation.
METHODS
We developed a 2D U-Net as an AI second observer for detecting colorectal cancer (CRC) and an ensemble of 5 differently initiated 2D U-Net for ensemble technique. Each model was trained with 51 cases of annotated CRC computed tomography of the abdomen and pelvis, tested with 7 cases, and validated with 20 cases from The Cancer Imaging Archive cases. The sensitivity, false positives per case, and estimated Dice coefficient were obtained for each method of training. We compared the two methods of annotations and the time reduction associated with the technique. The time differences were tested using Friedman’s two-way analysis of variance.
RESULTS
Sparse annotation significantly reduces the time for annotation particularly skipping 2 slices at a time (P < 0.001). Reduction of up to 2/3 of the annotation does not reduce AI model sensitivity or false positives per case. Although initializing human annotation with AI reduces the annotation time, the reduction is minimal, even when using an ensemble AI to decrease false positives.
CONCLUSION
Our data support the sparse annotation technique as an efficient technique for reducing the time needed to establish the ground truth.
Efficacy and prognostic impact of Pericarpium Trichosanthis injection combined with nicorandil for intractable angina pectoris in elderly patients: A retrospective study
Authors: Li Jun , Kong Mo-Wei , Xie Yu-Yu , Wang Ze-Bi , Xu Li , He Guo-Xiang 
Published: December 2023

BACKGROUND
Coronary artery disease (CAD) is a leading cause of global cardiovascular mortality. Refractory angina pectoris, a manifestation of CAD, requires effective drug treatments. Pericarpium Trichosanthis injection, a traditional Chinese medicine, improves cardiovascular symptoms, while nicorandil alleviates spasms and angina. Both have potential in treating CAD.
AIM
To investigate the therapeutic effects of combining Pericarpium Trichosanthis injection and nicorandil in elderly patients suffering from refractory angina caused by coronary heart disease.
METHODS
A retrospective analysis was conducted on the data of 130 patients diagnosed with refractory coronary heart disease. Based on the different treatment regimens administered during hospitalization, the patients were divided into a control group (58 cases) and a study group (72 cases). The control group received conventional treatment, which included aspirin, statins, and nitrate vasodilators. In addition to the conventional medication, the study group received a combination treatment of Pericarpium Trichosanthis injection and nicorandil.
RESULTS
After treatment, the study group showed significantly higher left ventricular ejection fraction and cardiac output, and lower brain natriuretic peptide and C-reactive protein levels compared to the control group. The study group also exhibited improvements in angina, quality of life, exercise endurance, and lipid profiles. Multivariate logistic regression analysis revealed a relationship of lipid levels and heart function with the combined treatment. Some patients in the study group experienced headaches during treatment, but no significant adverse reactions were observed. Follow-up showed that the treatment was well-tolerated, with no drug-related adverse reactions detected.
CONCLUSION
Combination of Pericarpium Trichosanthis injection and nicorandil is more effective than conventional treatment in improving symptoms and heart function in elderly patients with refractory angina pectoris.
Pulmonary and tricuspid regurgitation after Tetralogy of Fallot repair: A case report
Authors: Cao Jing-Yi , Ning Xiao-Ping , Zhou Guang-Wei , Li Bai-Ling , Qiao Fan , Han Lin , Xu Zhi-Yun , Lu Fang-Lin 
Published: December 2023

BACKGROUND
Tetralogy of Fallot (TOF) is one of the most common congenital heart defects, and surgery is the primary treatment. There are no precise guidelines on the treatment protocol for tricuspid regurgitation (TR) as a common complication of TOF repair. The timing for treatment in patients presenting with valve regurgitation after TOF repair is often difficult to determine. Here, we report the first case of sequential treatment of pulmonary and TR using interventional therapy.
CASE SUMMARY
We present the case of a 52-year-old female patient, who had a history of TOF repair at a young age. A few years later, the patient presented with pulmonary and tricuspid regurgitation. The symptoms persisted and TR worsened following percutaneous pulmonary valve implantation. Preoperative testing revealed that the patient’s disease had advanced to an intermediate to advanced stage and that her general health was precarious. Because open-heart surgery was not an option for the patient, transcatheter tricuspid valve replacement was suggested. This procedure was successful, and the patient recovered fully without any adverse effects. This case report may serve as a useful resource for planning future treatments.
CONCLUSION
Treatment of both valves should be considered in patients with tricuspid and pulmonary regurgitations following TOF repair. The interventional strategy could be an alternative for patients with poor general health.
Modular Bodies of Animated Characters and Posthumanist Connotations. Translation into Russian
Authors: Oktan Ahmet , Akyol Oktan Kevser , Çon Gülsüm Büşra 
Published: December 2023

This article discusses the molecularization of the body and the meanings pointed out via cyborg bodies in the context of animated characters. We analyze films of Ghost in the Shell (Mamoru Oshii, 1995), Ghost in the Shell: SAC_2045- Sustainable War (Shinji Aramaki Michihito and Fujii Kenji Kamiyama, 2021), Gunnm (Hiroshi Fukutomi, 1993), and Alita: Battle Angel (Robert Rodriguez, 2019) in the context of related philosophical discussions. We carry out the discussion about the body on two axes. First, we examine forms of presenting the modular bodies and discuss their socio-cultural connections. In these narratives, the evolution of the body beyond organic boundaries transforms it into a space where the character reflects the subjectivity and a tool that offers a narcissistic experience of omnipotence regarding bodily strength and competence. However, it sometimes causes the characters to become alienated from their bodies and engage in existential inquiries. Thus, secondly, we examine the existential inquiries/crises of the characters arising from the modularization of their bodies and the philosophical connotations that these emphases indicate. If on this axis, posthumanist arguments that stand out with objections to Cartesian distinctions such as machine-human, mind-body, woman-man, and anthropocentric approaches constitute the focus of the discussions.