bluuebunny/crossref_metadata_2025_split huggingface dataset:
Baseline Serum Inflammatory Proteins Predict Poor CAR T Outcomes in Diffuse Large B-cell Lymphoma
Authors: Faramand Rawan G. , Lee Sae Bom , Jain Michael D. , Cao Biwei , Wang Xuefeng , Rejeski Kai , Subklewe Marion , Fahrmann Johannes F. , Saini Neeraj Y. , Hanash Samir M. , Kang Yun Pyo , Chang Darwin , Rodriguez Paolo C. , Dean Erin A. , Nishihori Taiga , Shah Bijal D. , Lazaryan Aleksandr , Chavez Julio , Khimani Farhad , Pinilla-Ibarz Javier A. , Dam Marian , Reid Kayla M. , Corallo Salvatore A. , Menges Meghan , Hidalgo Vargas Melanie , Mandula Jay K. , Holliday Brian A. , Bachmeier Christina A. , Speth Kelly , Song Qinghua , Mattie Mike , Locke Frederick L. , Davila Marco L. 
Published: January 2024

Abstract

A subset of patients with diffuse large B-cell lymphoma (DLBCL) treated with CD19 chimeric antigen receptor (CAR) T-cell therapy have poor clinical outcomes. We report serum proteins associated with severe immune-mediated toxicities and inferior clinical responses in 146 patients with DLBCL treated with axicabtagene ciloleucel. We develop a simple stratification based on pre-lymphodepletion C reactive protein (CRP) and ferritin to classify patients into low-, intermediate-, and high-risk groups. We observe that patients in the high-risk category were more likely to develop grade ≥3 toxicities and had inferior overall and progression-free survival. We sought to validate our findings with two independent international cohorts demonstrating that patients classified as low-risk have excellent efficacy and safety outcomes. Based on routine and readily available laboratory tests that can be obtained prior to lymphodepleting chemotherapy, this simple risk stratification can inform patient selection for CAR T-cell therapy.

Significance:
CAR T-cell therapy has changed the treatment paradigm for patients with relapsed/refractory hematologic malignancies. Despite encouraging efficacy, a subset of patients have poor clinical outcomes. We show that a simple clinically applicable model using pre-lymphodepletion CRP and ferritin can identify patients at high risk of poor outcomes.
This article is featured in Selected Articles from This Issue, p. 80
GROWTH, PHOTOSYNTHESIS AND PROLINE ACCUMULATION OF METAL-ACCUMULATOR WEEDS
Authors: Hamim Hamim , Apriani Rani , Saprudin Deden , Sulistyaningsih Yohana C 
Published: January 2024

Heavy metals especially lead and mercury contaminant have been spread widely because of their intensive utilization in industry or extraction in mining area which threaten our environment. The experiment aimed to examine the growth and some physiological parameters of five metal-accumulator weed species in response to mercury (Hg) and lead (Pb) treatment. Five weed species (Branchiaria mutica, Cyperus kyllingia, Ipomea aquatica, Mikania micrantha, and Paspalum conjugatum) were grown in water culture using half strength Hoaglandâ€™s solution and subjected to Hg(NO3)2 and PB(NO3)2 at 0, Â 0.25 and 0.5 mM for 3 weeks. The growth, photosynthesis, lipid peroxidation and proline content were observed during the treatments. The result showed that both Hg and Pb decreased growth significantly, but the decrease was far higher in Hg than in Pb treatments. Hg treatment reduced photosynthetic rate dramatically under different photosynthetic photon flux density suggesting that heavy metal Hg until 0.5 mM caused the damage of photosynthetic apparatus almost all species except in I. aquatica. Hg and Pb treatment caused dramatic increase in leaf MDA content, which was associated with the decrease of chlorophyll content significantly. Almost all the species were tolerant to Pb treatment up to 0.5 mM except M. micrantha, while only C. kyllingia and I. aquatica were tolerant to Hg treatment up to 0.5 mM. Only Hg treatment and not Pb that induced higher proline content in the leaves of threated plants without clear pattern of the increment among the species suggesting that proline may have a role as alarm stress rather than tolerant indicator.
PHYTASE PRODUCTION BY Enterobacter cloacae
Authors: Suliasih Suliasih , Widawati Sri 
Published: January 2024

Â This study aims to isolate the phytase producing bacteria (PPB), a plant growth promoting rhizobacteria (PGPR), from 1Cigna sinensis rhizosphere and to optimize its physicochemical conditioning. Phytase is an enzyme that can hydrolyze the phosphoester bond in organic phosphorus (phytic acid) to form ester phosphate and inorganic phosphate, the available forms of phosphorus. To test its ability to hydrolyze organic phosphates (calcium phytate), the phytase was screened in solid and liquid phytase screening medium (PSM). After isolation, a total of 13 bacteria were positive for this enzymeâ€™s production as indicated by the clear zones of hydrolysis observed around the colony. Enterobacter cloacae strain B1 had the largest hydrolysis efficient (3.43) on solid medium. The phytase-production of the Enterobacter cloacae strain grown in liquid PSM, showed 0.92 U/mL after 48 hours of incubation. This strain produced optimum levels of phytase in the presence of lactose and monoammonium phosphate (NH4H2PO4), as carbon and nitrogen sources, respectively, at 30 Â°C and pH 5.0. The PPB obtained in this study are recommended for further research as to their use as plant biological fertilizers.Â Â
P2X7
-Mediated Antigen-Independent Activation of CD8
+
T Cells Promotes Salt-Sensitive Hypertension
Authors: Benson Lance N. , Deck Katherine S. , Mora Christoph J. , Guo Yunping , Rafferty Tonya M. , Li Lin-Xi , Huang Lu , Andrews J. Tucker , Qin Zhiqiang , Trott Daniel W. , Hoover Robert S. , Liu Yunmeng , Mu Shengyu 
Published: January 2024

BACKGROUND:

CD8
+
T cells (CD8Ts) have been implicated in hypertension. However, the specific mechanisms are not fully understood. In this study, we explore the contribution of the P2X7 (purinergic receptor P2X7) receptor to CD8T activation and subsequent promotion of sodium retention in the kidney.

METHODS:
We used mouse models of hypertension. Wild type were used as genetic controls, OT1 and Rag2/OT1 mice were utilized to determine antigen dependency, and P2X7-knockout mice were studied to define the role of P2X7 in activating CD8Ts and promoting hypertension. Blood pressure was monitored continuously and kidneys were obtained at different experimental end points. Freshly isolated CD8Ts from mice for activation assays and ATP stimulation. CD8T activation-induced promotion of sodium retention was explored in cocultures of CD8Ts and mouse DCTs.

RESULTS:
We found that OT1 and Rag2/OT1 mice, which are nonresponsive to common antigens, still developed hypertension and CD8T-activation in response to deoxycorticosterone acetate/salt treatment, similar to wild-type mice. Further studies identified the P2X7 receptor on CD8Ts as a possible mediator of this antigen-independent activation of CD8Ts in hypertension. Knockout of the P2X7 receptor prevented calcium influx and cytokine production in CD8Ts. This finding was associated with reduced CD8T-DCT stimulation, reversal of excessive salt retention in DCTs, and attenuated development of salt-sensitive hypertension.

CONCLUSIONS:
Our findings suggest a novel mechanism by which CD8Ts are activated in hypertension to exacerbate salt retention and infer that the P2X7 receptor on CD8Ts may represent a new therapeutic target to attenuate T-cell-mediated immunopathology in hypertension.
The Threat of Economic Deglobalization from Cold War 2.0: A Japanese Perspective
Authors: Ando Mitsuyo , Hayakawa Kazunobu , Kimura Fukunari 
Published: January 2024

Abstract
The intensified geopolitical tension in Northeast Asia and the U.S.–China confrontation have shifted policy debates in Japan toward national security while the economic discussion has become thin. To regain more balanced policy talks, this paper tries to quantitatively comprehend the effect of the United States and its allies’ export controls on the East Asian machinery production networks and Japan's trade performance. Major findings include the following four points: First, most of the supply chain decoupling policies by the Japanese government have been the ones to prepare for sudden interruptions of the supply of important items while decoupling policies for strategic competition are limited only in the context of the cooperation with the United States. Second, international trade statistics at the industry level do not show clear evidence of supply chain decoupling in East Asia due to the U.S. export controls, at least up to 2022. Third, however, the negative trade effect becomes visible at the product or individual firms’ level, and the recent strengthening of the United States and its allies’ export controls may augment the negative effect on machinery production networks. Fourth, although the scope of trade controls would expand further, the supply chain decoupling is likely to end up with a partial one. The paper claims that middle powers such as Japan must establish a well-balanced trade policy.
Marx and the Concept of a Social Formation
Authors: Burns Tony 
Published: January 2024

Abstract
This paper discusses the significance of the concept of a social formation for historical materialism. It argues that the concept is wrongly thought to be associated uniquely with the writings of Louis Althusser and with structuralist Marxism. It can be found in the writings of Marx himself, as well as those of Lenin, and is central to an adequate understanding of classical Marxism. To illustrate its importance the paper shows how the concept may be used to shed new light on the debate around the transition from feudalism to capitalism.
Taxonomic studies on the genera Echinovelleda Breuning, 1936 and Propedicellus Huang, Huang & Liu, 2020 (Coleoptera, Cerambycidae, Lamiinae, Lamiini)
Authors: BI WEN-XUAN , MU CHEN , LIN MEI-YING 
Published: January 2024

The genera Echinovelleda Breuning, 1936 and Propedicellus Huang, Huang & Liu, 2020 are revised. The latter is considered to be a junior synonym of the former based on a comprehensive morphological investigation, especially on the characteristics of male endophallus. Two new species are described from China, viz. Echinovelleda mumuae Bi & Mu sp. nov. from Yunnan and Guangxi, and E. protochinensis Bi & Lin sp. nov. from Yunnan and Sichuan. New records are reported for previously described taxa including one new country record of a morphologically similar genus, Hechinoschema Thomson, 1857 from China. Illustrations of habitus, endophallic structure, major diagnostic features for all studied taxa, as well as a distributional map are provided.
Uncertainties in the Projection of Dynamic Sea Level in CMIP6 and FGOALS-g3 Large Ensemble
Authors: Jin Chenyang , Liu Hailong , Lin Pengfei , Li Yiwen 
Published: January 2024

Abstract
Decision-makers need reliable projections of future sea level change for risk assessment. Untangling the sources of uncertainty in sea level projections will help narrow the projection uncertainty. Here, we separate and quantify the contributions of internal variability, intermodel uncertainty, and scenario uncertainty to the ensemble spread of dynamic sea level (DSL) at both the basin and regional scales using Coupled Model Intercomparison Project phase 6 (CMIP6) and FGOALS-g3 large ensemble (LEN) data. For basin-mean DSL projections, intermodel uncertainty is the dominant contributor (>55%) in the near term (2021–40), midterm (2041–60), and long term (2081–2100) relative to the climatology of 1995–2014. Internal variability is of secondary importance in the near- and midterm until scenario uncertainty exceeds it in all basins except the Indian Ocean in the long term. For regional-scale DSL projections, internal variability is the dominant contributor (60%–100%) in the Pacific Ocean, Indian Ocean, and western boundary of the Atlantic Ocean, while intermodel uncertainty is more important in other regions in the near term. The contribution of internal variability (intermodel uncertainty) decreases (increases) in most regions from midterm to long term. Scenario uncertainty becomes important after emerging in the Southern, Pacific, and Atlantic Oceans. The signal-to-noise ratio (S/N) maps for regional DSL projections show that anthropogenic DSL signals can only emerge from a few regions. Assuming that model differences are eliminated, the perfect CMIP6 ensemble can capture more anthropogenic regional DSL signals in advance. These findings will help establish future constraints on DSL projections and further improve the next generation of climate models.

Significance Statement
Clarifying the sources of uncertainty in DSL projections is fundamental for further improving projections. Hence, this study aims to separate and quantify the three uncertainties in both basin and regional scale DSL projections using CMIP6 models and a 110-member large-ensemble experiment: internal variability, intermodel, and scenario uncertainty. We show that intermodel uncertainty is the dominant contributor at both the basin and regional scale, even though internal variability plays an important role in most regions of the Indian Ocean, Pacific Ocean, and Atlantic Ocean. Scenario uncertainty is negligible before it emerges at both the basin and regional scale in the long term. This provides the direction for constraining uncertainty in DSL projections.
The Impact of Analysis Correction-Based Additive Inflation on Subseasonal Tropical Prediction in the Navy Earth System Prediction Capability
Authors: Rushley Stephanie S. , Janiga Matthew A. , Crawford William , Reynolds Carolyn A. , Komaromi William , McLay Justin 
Published: January 2024

Abstract
Accurately simulating the Madden–Julian oscillation (MJO), which dominates intraseasonal (30–90 day) variability in the tropics, is critical to predicting tropical cyclones (TCs) and other phenomena at extended-range (2–3 week) time scales. MJO biases in intensity and propagation speed are a common problem in global coupled models. For example, the MJO in the Navy Earth System Prediction Capability (ESPC), a global coupled model, has been shown to be too strong and too fast, which has implications for the MJO–TC relationship in that model. The biases and extended-range prediction skill in the operational version of the Navy ESPC are compared to experiments applying different versions of analysis correction-based additive inflation (ACAI) to reduce model biases. ACAI is a method in which time-mean and stochastic perturbations based on analysis increments are added to the model tendencies with the goals of reducing systematic error and accounting for model uncertainty. Over the extended boreal summer (May–November), ACAI reduces the root-mean-squared error (RMSE) and improves the spread–skill relationship of the total tropical and MJO-filtered OLR and low-level zonal winds. While ACAI improves skill in the environmental fields of low-level absolute vorticity, potential intensity, and vertical wind shear, it degrades the skill in the relative humidity, which increases the positive bias in the genesis potential index (GPI) in the operational Navy ESPC. Northern Hemisphere integrated TC genesis biases are reduced (increased number of TCs) in the ACAI experiments, which is consistent with the positive GPI bias in the ACAI simulations.
Serum Albumin for Short-Term Poor Prognosis in Patients With Acute Pulmonary Embolism: A Clinical Study Based on a Database
Authors: Qiu Jiayong , Hao Yingying , Huang Shenshen , Wang Tongsheng , He Xuegai , Wang Wei , Du Dan , Mao Yimin , Yuan Yadong 
Published: January 2024

The relationship between serum albumin (ALB) and short-term prognosis in patients with acute pulmonary embolism (APE) remains unclear. We investigated the predictive value of ALB for short-term prognosis in APE patients using our hospital pulmonary embolism (PE) database (384 patients consecutively collected). Logistic regression analysis and nomograms were applied to construct the predictive model, and validation was assessed. A total of 340 APE patients were included, with a 30-day all-cause mortality rate of 8.5%. The incidence of hypoalbuminemia was 15.9%. The odds ratio (OR) for short-term mortality in patients with high ALB was 0.89 (0.886, 95% CI: 0.812–0.967). Additionally, we created a nomogram for individualized mortality risk prediction. Receiver operating characteristic (ROC) curve analysis showed that the diagnostic area under the curve (AUC) of ALB was 0.758 (95% CI 0.683–0.833), and the best cut-off value was 33.85 g/L. Optimal simplified Pulmonary Embolism Severity Index (sPESI) (ALB combined sPESI) AUC was 0.835 (95% CI 0.775–0.896). Baseline hypoalbuminemia may be an independent prognostic indicator of short-term mortality in patients with APE.
How Is Institutional Quality Moderating the Effect of Terrorism on International Tourism, Trade, Foreign Aid Inflow and Economic Growth in Sub-Saharan Africa?
Authors: Agu Christian , Ogbuabor Jonathan Emenike , Onah Benjamin Udoka 
Published: January 2024

This study examines how international tourism, foreign aid inflow, international trade and economic growth are responding to terrorism in Sub-Saharan Africa (SSA), and how institutions are moderating these interactions. To answer these questions, we examined a panel of 40 SSA countries for the period 2010–2020 based on the system generalised method of moments framework. Our results revealed that: (a) terrorism impacts adversely on tourism, foreign aid inflow, trade and overall economic growth in SSA; and (b) institutional quality has not been effective in mitigating the adverse effects of terrorism on tourism, foreign aid inflow, trade and economic growth in SSA. Policy implications are discussed. JEL Codes: C33; F10; F35; F43; L83; N20
Communication Strategies in Human-Autonomy Teams During Technological Failures
Authors: Harrison Julie L. , Zhou Shiwen , Scalia Matthew J. , Grimm David A. P. , Demir Mustafa , McNeese Nathan J. , Cooke Nancy J. , Gorman Jamie C. 
Published: January 2024

Objective This study examines low-, medium-, and high-performing Human-Autonomy Teams’ (HATs’) communication strategies during various technological failures that impact routine communication strategies to adapt to the task environment. Background Teams must adapt their communication strategies during dynamic tasks, where more successful teams make more substantial adaptations. Adaptations in communication strategies may explain how successful HATs overcome technological failures. Further, technological failures of variable severity may alter communication strategies of HATs at different performance levels in their attempts to overcome each failure. Method HATs in a Remotely Piloted Aircraft System-Synthetic Task Environment (RPAS-STE), involving three team members, were tasked with photographing targets. Each triad had two randomly assigned participants in navigator and photographer roles, teaming with an experimenter who simulated an AI pilot in a Wizard of Oz paradigm. Teams encountered two different technological failures, automation and autonomy, where autonomy failures were more challenging to overcome. Results High-performing HATs calibrated their communication strategy to the complexity of the different failures better than medium- and low-performing teams. Further, HATs adjusted their communication strategies over time. Finally, only the most severe failures required teams to increase the efficiency of their communication. Conclusion HAT effectiveness under degraded conditions depends on the type of communication strategies enacted by the team. Previous findings from studies of all-human teams apply here; however, novel results suggest information requests are particularly important to HAT success during failures. Application Understanding the communication strategies of HATs under degraded conditions can inform training protocols to help HATs overcome failures.
Role of Pubertal Timing and Perceived Parental Attachment in Internalizing Problem Behaviours Among Adolescents
Authors: Kanwar Palak 
Published: January 2024

Adolescents need supportive social institutions to help them deal effectively with the demands of pubertal changes accompanied by new social roles, reducing their susceptibility to problem behaviors. Considering this, it will be investigated how internalizing problem behaviors in teenagers is affected by the interaction between pubertal timing and perceived parental attachment. For this, cross-sectional data from 772 adolescents with ages ranging from 11 to 15 years old was used. Regression analyses showed early maturing adolescents with insecure perceived parental attachments had higher levels of depression and anxiety than their early, on-time, and late maturing counterparts with secure perceived parental attachments. This finding supports the contextual amplification model, as the detrimental consequences of early maturation are impacted by difficult parent-adolescent relationships.
Use of the Capability, Opportunity and Motivation Behaviour model (COM-B) to Understand Interventions to Support Physical Activity Behaviour in People with Stroke: An Overview of Reviews
Authors: Paterson Sarah , Dawes Helen , Winward Charlotte , Bartram Emilia , Dodds Emma , McKinon Jane , Gaskell Helen , Collett Johnny 
Published: January 2024

Objective Physical activity in people with stroke remains low despite considerable research. This overview aimed to provide high-level synthesis and aid clinical decision-making. The Capability, Opportunity, Motivation-Behaviour (COM-B) model was used to classify interventions to understand which components improve physical activity behaviour in people with stroke. Data Sources CINAHL, Cochrane Database, MEDLINE, PEDro, PsychINFO, SPORTDiscus Review Methods A systematic search was conducted (November 2023) to identify reviews of interventions to improve physical activity in people with stroke. Results were screened and assessed for eligibility. Participant characteristics, intervention classification using COM-B, and effect of intervention were extracted. Quality was assessed using AMSTAR2, and Corrected Cover Analysis for study overlap. Narrative synthesis was used to understand components of interventions to improve physical activity behaviour. Results 1801 references were screened and 29 full-text references assessed for eligibility. Twenty reviews were included. Quality ranged from critically low ( n = 3) to high ( n = 10). Study overlap calculated using corrected cover area indicated slight overlap (0.028) and minimal reporting bias. The majority of participants were mobile with mild stroke and community dwelling. Twenty-three interventions were classified using COM-B. Three of twelve interventions classified to one aspect of the COM-B were effective. Fourteen of sixteen effective interventions combined at least two COM-B elements, ten of these combined capability and motivation. Conclusion Interventions including at least two elements of the COM-B are most likely to improve physical activity in mobile stroke survivors. Further research is needed to understand physical activity behaviour in those with moderate to severe stroke.