bluuebunny/crossref_metadata_2025_split huggingface dataset:
Cellular Senescence and Senolytic Agents: Recent Updates on Their Role and Applications
Authors: Chandrakar Lokesh , Ambatwar Ramesh , Khatik Gopal L. 
Published: December 2023

Abstract:Cellular senescence, an eternal condition of cell cycle arrest due to cellular stressors, is a sign of aging. Senescent cells (SCs) build up in tissues as they age, impairing their ability to repair themselves by causing the cell cycle to seize in progenitor cells and producing proinflammatory and the senescence-associated secretory phenotype (SASP) or matrix-degrading molecules. SASP aids in the emergence of several age-related diseases. Genetic studies have shown that removing SCs can delay aging and prolong life. Senolytics are small molecules designed to treat numerous age-related disorders can selectively kill SCs. A detailed discussion on senolytics and their potential as therapeutics to treat neuro-disorder and slow down aging is described herein. Emerging natural products, such as quercetin, dasatinib, fisetin, piperlongumine, and curcumin, have recently been reported to be effective senolytic agents, and some structurally modified analogue of these have also been explored for better selectivity and efficacy in animal models. These showed significant potential in clinical studies and could be developed as senolytic drugs in the future.
Subcutaneous Cavernous Haemangioma in a Patient with Klippel-Trenaunay
Syndrome: A Case Report
Authors: Liu Yixin , Liu Ling , Liu Xia , Liu Rengui , Cui Chunmao , Cao Huaize 
Published: December 2023

Background::
Klippel-Trenaunay syndrome (KTS) is a rare congenital disease that mainly involves blood vessels and is characterized by the presence of capillary
malformations (port wine stains), varicose veins, soft tissue and/or bone hypertrophy.

Case Presentation::
We report a 28-year-old man who was diagnosed 20 years ago with Klippel-Trenaunay syndrome. Approximately 3 years ago, he found an
enlarged mass on both upper extremities and a new dark red mass that was pathologically diagnosed as cavernous haemangioma appeared on the
right index finger.

Conclusion::
KTS is a rare and potentially multisystem disease requiring multidisciplinary management for which imaging examination is an important auxiliary
diagnostic method. Various complications may occur during its development, so regular follow-up is required to prevent serious accidents.
Discerning the Multi-dimensional Role of Salicin: Bioactive Glycoside
Beyond Analgesic: Different Perspectives
Authors: Pal Rashmi Saxena , Pal Yogendra , Lalitha Chaitanya Motamarri Venkata Naga , Mazumder Avijit , Khurana Navneet , Tharu Prabin Kumar 
Published: December 2023

:
Salicin is a glycoside that can be found in several Salix and Populus species. Salicin is also
connected to the glycoside populin, commonly known as benzoyl Salicin, in the Salicaceae tree barks.
D-glucose is a component of the alcoholic glycoside Salicin (C13H18O7). The willow tree, as well as
other trees like poplar and aspen, contains the natural chemical Salicin, which is a member of the
salicylate family. Salicin is an anti-inflammatory and analgesic used in conventional medicine, and it
served as the inspiration for the creation of aspirin. This molecule may have important human pharmacological
actions that need to be considered in determining the efficacy and safety of willow herbal
medicines. The extracts obtained from the bark of the tree, belonging to the Saliceae family in different
solvents have been known for possessing many important medicinal values by potent pharmacological
actions. The current effort deals with exquisite detailed aspects and concerns related to Salicin,
which will be fruitful for the futuristic approaches to Salicin.
A Comprehensive Review of the Pharmacological Effects of Genus Ferula
on Central Nervous System Disorders
Authors: Bagheri Seyyed Majid , Esmailidehaj Mansour 
Published: December 2023

Background:
Plants of the genus Ferula have long been used to treat neurological
diseases such as Alzheimer's disease (AD), pain, depression, and seizures. The main compounds
include coumarins, monoterpenes, sulfide compounds, and polyphenol compounds, which can
improve the functioning of the nervous system.

Objective:
This article has been compiled with the aim of collecting evidence and articles related to
the Ferula effects on central nervous system disease.

Methods:
This review article was prepared by searching the terms Ferula and analgesic,
anticonvulsant, antidepressant, anti-multiple sclerosis, anti-dementia, and neuroprotective
effects.The relevant information was collected through searching electronic databases such as ISI
Web of Knowledge, PubMed, and Google Scholar.

Results:
Genus Ferula has a protective effect on nerve cells by reducing cytokines such as IL-6, IL-
1b, and TNF-α. Therefore, the effects of Ferula plants and their effective ingredients can be used to
prevent or improve diseases that destroy the nervous system. The members of this genus play a role
in strengthening and improving the antioxidant system, reducing the level of oxidative stress, and
inhibiting or reducing inflammatory factors in the nervous system.

Conclusion:
Although the effects of several species of Ferula on the nervous system have been investigated,
most studies have not clearly identified the molecular mechanisms as well as the specific
functional regions of the brain. The present study was compiled in order to investigate different
aspects of the effects of Ferula plants on the central nervous system.
Understanding the Relationship between the Ketogenic Diet and the Heart: A Novel Therapeutic Potential for Cardiovascular Health
Authors: Shah Priyanshi , Sawhney Aanchal , Anamika FNU , Kanagala Sai Gautham , Parikh Kinna , Mendpara Vaidehi , Garg Nikita , Jain Rohit 
Published: December 2023

:
Obesity and cardiovascular diseases are major health problems worldwide, and weight
loss is used as a treatment strategy to enhance various aspects. While there are many weight loss
methods, one of the most effective is through a dietary approach. The ketogenic diet (KD),
which is characterized by low carbohydrates and high levels of fat and/or protein, is used in
obese patients as it is a promising treatment option for weight loss as well as for controlling the
risk factors for cardiovascular diseases, as seen in its effects on cardio-metabolic outcomes, particularly
in obesity, heart failure, and hypertension. In this review, we summarize the clinical
evidence of the efficacy and safety of the KD in controlling risk factors for cardiovascular diseases
and discuss the possible mechanisms of action based on recent evidence in understanding
the influence of the KD at the cellular and molecular levels.
Thymus atlanticus (Ball) Roussine Aqueous Extract Exerts Lipid-lowering
and Anti-atherosclerotic Effects in Hyperlipidemic Guinea Pigs
Authors: Elbouny Hamza , Ouahzizi Brahim , Bekkouch Oussama , Bennani Amal , Amrani Souliman , Ramchoun Mhamed , Sellam Khalid , Alem Chakib 
Published: December 2023

Background::
Thymus atlanticus (Ball) Roussine (T. atlanticus) is traditionally used in
the Moroccan high Atlas Mountains to treat several disorders, including cardiovascular disease.
In the present study, the lipid-lowering and anti-atherosclerotic activities of the traditionally used
aqueous extract of T. atlanticus were evaluated on guinea pigs subjected to chronic hyperlipidemia.

Methods::
Animals were given a diet containing 2% cholesterol and 20% lard for 12 weeks.
Moreover, thyme extract was given daily at 400 mg/kg. At the end of the experiment, lipid levels
and paraoxonase arylesterase activity were measured, and aorta histology was studied.

Results::
Our findings revealed that there was an important elevation of blood lipids in the HFD
group along with a significant decrease in paraoxonase arylesterase activity (-40.06%). Moreover,
the consumption of fat altered the histology of aorta by thickening the intima media and
forming atherosclerotic lesions and foam cells in these tissues. However, the administration of
thyme extract attenuated HFD-caused alterations by decreasing blood lipids, elevating
paraoxonase activity (+24.04%), and limiting the progression of atherosclerotic lesions.

Conclusion::
We conclude that the supplementation with the aqueous extract of T. atlanticus
could potentially protect against hyperlipidemia and consequently, the development of atherosclerosis
Analysis of the Efficacy and Safety of Palonosetron Hydrochloride in
Preventing Nausea And Vomiting After TACE: A Retrospective Analysis
Authors: Lu Haohao , Zheng Chuansheng , Liang Bin , Xia Xiangwen 
Published: December 2023

Purpose:
To investigate the mechanism of nausea and vomiting after TACE, and
analyze the efficacy and safety of palonosetron hydrochloride in the prevention of nausea and
vomiting after TACE.

Methods:
The data of 221 patients who underwent TACE in the Department of Intervention
Therapy from August 2018 to August 2020 were collected. The patients were divided into two
groups: those who did not use palonosetron hydrochloride before TACE (TACE group, N=116);
and those who used palonosetron hydrochloride before TACE (TACE+palonosetron group,
N=105). Primary study endpoint: The control rate of nausea and vomiting in the two groups at
0-24 h (acute), 24-120 h (delayed), and 0-120 h. Secondary Study Endpoints: Adverse events of
palonosetron hydrochloride.

Results:
TACE group vs TACE+palonosetron group: 0-24 h, 74 vs. 44 patients with nausea
(63.8% vs. 41.9%); 24-120 h, 50 vs. 16 patients with nausea (43.1% vs. 15.2%); 0-120 h after
TACE, 81 vs. 50 patients with nausea (69.8% vs. 47.6%). 0-24 h, 52 vs. 26 patients with vomiting
(44.8% vs. 24.8%); 24-120 h, 24 vs. 8 patients with vomiting (20.7% vs. 7.6%); 0-120 h after
TACE, 64 vs. 26 patients with vomiting (55.2% vs. 24.8%). The incidence of nausea and
vomiting after TACE was significantly lower in the TACE+palonosetron group than in the
TACE group (p < 0.05).

Conclusion:
Palonosetron hydrochloride can significantly reduce the incidence of nausea and
vomiting in patients after TACE, with exact effect and high safety.
The effects of incretin mimetics on the level of the microbial metabolite trimethylamine-N-oxide, a marker of cardiovascular risk in type 2 diabetic patients
Authors: Shyshkan-Shyshova K.O. , Zinych O.V. , Кushnareva N.M. , Кovalchuk A.V. , Prybyla О.V. 
Published: December 2023

Background. The purpose was to investigate the effect of therapy with glucagon-like peptide-1 receptor agonists (GLP-1ra) on the serum concentration of trimethylamine-N-­oxide (TMAO), an intestinal microbiome metabolite, in patients with type 2 diabetes mellitus (T2DM) in relation to clinical and laboratory indicators and parameters of body composition. Materials and methods. Thirty-three T2DM patients (17 women and 16 men) were examined aged 31 to 72 years who had unsatisfactory control of carbohydrate metabolism (HbA1c > 7.4 %) against the background of previous glucose-lowering therapy (metformin, sulfonylurea derivatives, insulin, gliflozin) and were administered GLP-1ra. Before the start of treatment and after 6 months of therapy, parameters of anthropometry, body composition were measured (using the bioelectrical impedance analysis with the Tanita analyzer); blood glucose and glycated hemoglobin, TMAO concentration, blood lipids were assessed. Results. Patients diagnosed with Т2DM had HbA1c > 7.4 %; 91 % had general obesity (body mass index 34.7 ± 6.6 kg/m2), 100 % had abdominal obesity (waist circumference 118.00 ± 11.24 cm, Med ± SD). In 72 % of cases, there was a history of cardiovascular complications (myocardial infarction, stroke, coronary and peripheral atherosclerosis, arterial stenosis). Under the influence of a 6-month administration of GLP1ra, there was a decrease in the degree of total and abdominal obesity, a significant drop in the percentage of fat and the level of visceral fat, which was accompanied by an increase in hydration, a reduction in triglyceridemia and the concentration of very-low-density lipoprotein cholesterol (VLDL-C). A significant decrease in the level of TMAO microbial metabolite in the blood serum was recorded, which may reflect the antiatherogenic effect of GLP1ra, associated with the control of cholesterol and bile acid metabolism, the stimulation of VLDL-C receptors, and the effect on the secretion of insulin, glucagon, ghrelin, leptin, incretins. Conclusions. A study on the clinical effects of the incretin mimetic (GLP-1ra) in patients with T2DM confirmed its positive impact on glucose metabolism and blood lipids. At the same time, during GLP-1ra therapy, an improvement of some compositional and lipid indicators (visceral fat, triglycerides, VLDL-C) was recorded with a simultaneous decrease in the concentration of TMAO toxic metabolite.
Roles y legitimidad de los envarados
Authors: Salas Guillermo 
Published: December 2023

This article analyzes the roles and legitimacy of the communal authorities at the Q’ero hacienda (Paucartambo, Cusco) and the communities emerging therefrom. The colonial state established the hacienda in the XVII century. However, in 1922, its authority structure was more characteristic of communities descending from colonial Councils of Indians (Cabildos de Indios). Based on ethnographic records beginning in 1922 and fieldwork conducted in 2007 and 2008, the article shows how communal indigenous authorities, whose external legitimacy came from the landlord and the state, were essential to organizing hacienda work. As part of their role as mediators between humans and ruwales (places with agency and intentionality), these authorities were responsible for the rainy season festivities. When the hacienda closed in the 1960s, the state recognized these collectives as ‘peasant communities’ and imposed a new authority structure. While these new authorities were in charge of the relations with the state, the communal indigenous authorities continued in their roles. Their legitimacy emerged directly from the community of humans and ruwales and was only weakly tied to the state.
Ground motion simulations of the 1887 Pinal de Amoles (MW = 5.53) and the 1989 Landa de Matamoros (MW = 4.94) earthquakes, Querétaro, Mexico
Authors: Rodríguez-Pérez Quetzalcoatl 
Published: December 2023

Ground motions characteristics of the 1887 Pinal de Amoles (MW = 5.53) and the 1989 Landa de Matamoros (MW = 4.94) Querétaro earthquakes were studied. For this purpose, the specific barrier model (SBM) was implemented in the context of the stochastic ground motion representation of earthquakes. The SBM was calibrated by modeling the peak ground acceleration (PGA) and the Fourier acceleration spectra (FAS) of the 11 May 2016 (MW = 4.80) Guadalajara earthquake. The calibration results showed that the SBM and selected source and path parameters were able to reproduce synthetic PGA and spectra in good agreement with observed waveforms; in particular, a stress drop of 160 bars fits the results better. Several rupture scenarios for the 1887 and 1989 events were performed by obtaining synthetic seismograms considering different values of stress drop (10, 30, 50, 100, 150, 200, 300, and 500 bars). For a typical stress-drop value of 100 bars, the PGA at distances of 10 and 200 km are in the following intervals: 2.57–295 cm/s2 and 1.72–186 cm/s2 for the Pinal de Amoles and Landa de Matamoros earthquakes, respectively. The results obtained in this study contribute toward a better understanding of strong ground motions in the region.
Legal Protection for Buildings with Traditional Architecture in the Modern Era of Bali
Authors: I Putu Andika Pratama  , I Made Artana  , Nathan Franklin  , Ni Made Anggia Paramesthi Fajar  , Putu Chandra Kinandana Kayuan  
Published: December 2023

Along with the times, Balinese traditional architecture is increasingly being eroded by modern architectural art and also by the occurrence of damages. The purpose of this paper is to analyze the protection of traditional architectural buildings in the modern Balinese era and problems related to the preservation of traditional architecture in the modern Balinese era. This research adopts the doctrinal research and uses primary, secondary and tertiary legal materials. These legal materials were collected using a card system with a statute approach, a fact approach, and an analytical conceptual approach. Findings of the study show that: first, according to national law, Balinese traditional architecture is a cultural heritage and is regulated in Indonesian Law Number 5 of 1992 concerning Cultural Heritage Objects. Meanwhile, in the Province of Bali, Balinese traditional architecture is regulated in the Regional Regulation of the Province of Bali Number 5 of 2005 concerning Architectural Requirements for Buildings; secondly, one of the ways taken by the Government of Bali Province to preserve Balinese traditional architecture is to apply it to buildings. Balinese architecture, besides being used in the physical form of buildings, is also applied to the design of fences and gates along the main roads and streets in the environment. Balinese architecture is also required to be applied to government-owned houses or buildings, and official residences.

Abstrak
Arsitektur tradisional Bali seiring perkembangan jaman semakin tergerus oleh seni arsitektur modern dan juga terjadinya kerusakan-kerusakan. Tujuan penulisan ini adalah menganalisis perlindungan bangunan arsitektur tradisional di era Bali modern dan permasalahan terkait pelestarian arsitektur tradisional di era Bali modern. Penelitian ini merupakan Doctrinal Research dengan menggunakan bahan hukum primer, sekunder dan tersier. Teknik pengumpulan bahan hukum dilakukan dengan sistem kartu dengan pendekatan perundang-undangan, pendekatan fakta, dan pendekatan analisis konseptual. Hasil dari penelitian ini yaitu: Pertama, Secara hukum nasional, arsitektur tradisional Bali merupakan salah satu cagar budaya dan diatur di dalam Undang-Undang Nomor 5 Tahun 1992 tentang Benda Cagar Budaya. Sedangkan di Provinsi Bali, arsitektur tradisional Bali telah diatur di dalam Peraturan Daerah Provinsi Bali Nomor 5 Tahun 2005 tentang Persyaratan Arsitektur Bangunan Gedung; kedua, Salah satu cara yang dilakukan oleh Pemerintah Provinsi Bali untuk pelestarian arsitektur tradisional Bali adalah dengan mengaplikasikannya pada bangunan gedung. Arsitektur Bali selain digunakan dalam bentuk fisik dari bangunan gedung, juga diberlakukan untuk desain pagar dan gerbang disepanjang jalan raya dan jalan lingkungan. Arsitektur Bali juga diwajibkan untuk digunakan terhadap bangunan atau gedung milik pemerintah, rumah dinas maupun rumah jabatan.
Guarantee of Protection of Electronic Land Certificates as Proof of Ownership of Land Rights
Authors: Akbar Ramadhan Nugroho  , Surya Anoraga  , Esfandiari Fitria 
Published: December 2023

Changes in information technology have an impact on the public service system, especially in the land sector which is experiencing a transition from Analog Certificates to Electronic Certificates which raises several challenges, one of which is in the field of law, in practice the power of law because electronic information and transactions cannot be used as evidence, but must meet certain requirements. The purpose of this research is to find out and analyze the legal force of Electronic Land Certificates and to find out the efforts made by the government to protect the Electronic Land Certificate system. The research method used is the Normative Juridical Approach. The results of this study are the legal protection of electronic certificates in proving that they have a position as legal electronic evidence have been recognized in the procedural law system in Indonesia, and have strong legal force. Electronic Land Certificates require a legal umbrella governing the use of Blockchain technology contained in the ITE Law to be delegated to an implementing regulation. This study concludes that Electronic Certificates have the same legal force as Analog Certificates. As an effort to support the use of Electronic Certificates, the government's role is needed in formulating laws that regulate the substance of the use of technology in electronic certificate database storage systems.
PENERAPAN MEDIA VIDEO ANIMASI DALAM MENINGKATKAN MAHAROH AL-ISTIMA’ SISWI KELAS VIIIB MTS PUTRI PONDOK PESANTREN AL-ISHLAHUDDINY KEDIRI
Authors: Fatma Tia , Suparmanto Suparmanto , Aufia Fitriana Chalisa Nur , Abdurrahman Azmy 
Published: December 2023

خلفية هذا البحث هي عدم القدرة على الاستماع إلى الطالبات مما يؤدي إلى عدم إتقانهن للتواصل باللغة العربية في الحياة اليومية في المدرسة. تهدف هذه الدراسة إلى تحديد نشاط طالبات الصف الثاني )ب( بالمدرسة المتوسطة معهد اصلاح الدين في تعلم اللغة العربية باستخدام وسائط الفيديو المتحركة ومدى فهمهن في الاستماع إلى الفيديو المتحرك. تستخدم هذه الدراسة المنهج النوعي والطريقة التي يستخدمها الباحثون هي المنهج الوصفي النوعي. تستخدم هذه الدراسة فئة واحدة فقط كموضوع بحث. الأدوات المستخدمة في هذا البحث هي الملاحظة والمقابلات. من الشرح أعلاه ، يمكن الاستنتاج أن تطبيق وسائط الفيديو المتحركة يمكن أن يحسن مهارات الاستماع لطالبات الصف الثاني )ب( بالمدرسة المتوسطة معهد اصلاح الدين.
IMPLEMENTASI METODE QISHAH QOSHIRAH UNTUK STIMULUS BERBICARA BAHASA ARAB
Authors: Supriyadi Moh. 
Published: December 2023

مستخلص
ويهدف هذا الباحث لمعرفة كيفية طريقة قصة قصيرة ومدى استجابة الطلاب في تعليم اللغة العربية، وخاصة في تنفيذ أنشطة تعليم مهارة الكلام. يستخدم الباحث في هذا البحث بمدخل النوعي الوصفي وبنوع البحث الميداني بحيث يجب شرح البيانات التي تم الحصول عليها بشكل واضح ومفصل، وفي هذه الباحث يستخدام المقابلة والملاحظة والتعاون لجمع البيانات. إن استخدام طريقة قصة ققصيرة مفيدة جدًا للطلاب في عملية تعليم مهارة الكلام ويسهل تطوير مهارات الطلاب في التكلم باللغة العربية، والقدرة على التعبير عن الأفكار التي تدور في أذهانهم وزيادة مهارتهم في التكلم.
Kritik Sastra Psikologis Pada Novel Penghujung Langit Karya Shofa Faridah Istiqomah
Authors: Fitrya Eviyani  , Shany Alfia , Astuti Rr. Dwi , Arfiandita Melvin 
Published: December 2023

Masalah dalam penelitian ini terdapat konflik batin seorang tokoh pada novel “Penghujung Langit” karya Shofa Faridah Istiqomah. Penelitian ini bertujuan untuk mengetahui psikologis sastra berupa konflik batin seorang tokoh pada novel Penghujung Langit karya Shofa Faridah Istiqomah berdasarkan teori Abraham Maslow. Metode penelitian ini menggunakan metode deskriptif kualitatif dengan teknik dokumentasi. Hasil penelitian dapat diketahui bahwa pada novel Penghujung Langit karya Shofa Faridah Istiqomah terdapat konflik batin yang dialami tokoh utamanya, yaitu rasa sedih 4 kutipan, rasa ketakutan 2 kutipan, rasa kecemasan 1 kutipan, rasa kebimbangan 2 kutipan, dan rasa bersalah 1 kutipan. Adapun faktor penyebab terjadinya konflik batin pada tokoh utama, yaitu tidak terpenuhinya kebutuhan fisiologis karena kekurangan ekonomi terdapat 1 kutipan, tidak terpenuhinya kebutuhan rasa cinta dan kasih sayang kedua orang tua terdapat 1 kutipan, dan tidak terpenuhinya kebutuhan penghargaan karena permasalahan ekonomi yang menyebabkan rasa bimbang muncul harus memilih melanjutkan cita-cita atau berhenti terdapat 1 kutipan. Simpulan dalam penelitian ini menunjukan bahwa dalam novel Penghujung Langit karya Shofa Faridah Istiqomah memiliki kelebihan yaitu dari segi cerita yang dapat memberikan motivasi untuk tetap tabah dalam menjalani berbagai permasalahan kehidupan, sedangkan kekurangan novel ini, terutama dari segi bahasanya banyak mengandung kata yang kurang berkaitan erat dengan isiceritanya sehingga mengaburkan tema ceritanya.
Kata kunci: Novel Di Penghujung Langit, Kritik Sastra, Konflik Batin, Psikologis