bluuebunny/crossref_metadata_2025_split huggingface dataset:
Prä- und posttherapeutische Dosimetrie der Radioembolisation
Authors: Brosch-Lenz Julia , Delker Astrid , Ilhan Harun 
Published: December 2023

ZusammenfassungDie transarterielle Radioembolisation (TARE) mit radioaktiv markierten Mikrosphären dient der gezielten Therapie primärer und sekundärer Lebertumore. Bei 90Y-markierten Glas- und Harzmikrosphären basiert die Behandlungsplanung auf 99mTc-MAA, während für 166Ho-PLAA-Mikrosphären eine Scout-Dosis an 166Ho-PLAA-Mikrosphären mit geringerer Aktivität zur Verfügung steht. Zur Steigerung der Effektivität der Therapie im Sinne der personalisierten Medizin wird bei der TARE zunehmend die personalisierte Dosimetrie etabliert. Dies beinhaltet die Berücksichtigung der Dosisverteilungen innerhalb von Tumoren als auch im normalen Lebergewebe. Zur Berechnung der In-vivo-Verteilung der absorbierten Dosis werden nach der Therapie Bildgebungsverfahren wie SPECT, PET und für 166Ho zusätzlich die MRT eingesetzt, um den Behandlungserfolg zu beurteilen. Dieses Manuskript bietet einen umfassenden Überblick über aktuelle Dosimetriemodelle für die prä- und posttherapeutische Beurteilung im Rahmen der TARE.
Trends and Disparities in Severe Maternal Morbidity Indicator Categories during Childbirth Hospitalization in California from 1997 to 2017
Authors: El Ayadi Alison M. , Lyndon Audrey , Kan Peiyi , Mujahid Mahasin S. , Leonard Stephanie A. , Main Elliott K. , Carmichael Suzan L. 
Published: December 2023

Objective Severe maternal morbidity (SMM) is increasing and characterized by substantial racial and ethnic disparities. Analyzing trends and disparities across time by etiologic or organ system groups instead of an aggregated index may inform specific, actionable pathways to equitable care. We explored trends and racial and ethnic disparities in seven SMM categories at childbirth hospitalization.
Study Design We analyzed California birth cohort data on all live and stillbirths ≥ 20 weeks' gestation from 1997 to 2017 (n = 10,580,096) using the Centers for Disease Control and Prevention's SMM index. Cases were categorized into seven nonmutually exclusive indicator categories (cardiac, renal, respiratory, hemorrhage, sepsis, other obstetric, and other medical SMM). We compared prevalence and trends in SMM indicator categories overall and by racial and ethnic group using logistic and linear regression.
Results SMM occurred in 1.16% of births and nontransfusion SMM in 0.54%. Hemorrhage SMM occurred most frequently (27 per 10,000 births), followed by other obstetric (11), respiratory (7), and sepsis, cardiac, and renal SMM (5). Hemorrhage, renal, respiratory, and sepsis SMM increased over time for all racial and ethnic groups. The largest disparities were for Black individuals, including over 3-fold increased odds of other medical SMM. Renal and sepsis morbidity had the largest relative increases over time (717 and 544%). Sepsis and hemorrhage SMM had the largest absolute changes over time (17 per 10,000 increase). Disparities increased over time for respiratory SMM among Black, U.S.-born Hispanic, and non-U.S.-born Hispanic individuals and for sepsis SMM among Asian or Pacific Islander individuals. Disparities decreased over time for sepsis SMM among Black individuals yet remained substantial.
Conclusion Our research further supports the critical need to address SMM and disparities as a significant public health priority in the United States and suggests that examining SMM subgroups may reveal helpful nuance for understanding trends, disparities, and potential needs for intervention.
Key Points
Synthesis of Novel Enantiopure Amino- and Azidopyran Building Blocks and Their Click Reactions to Multivalent Carbohydrate Mimetics
Authors: Reissig Hans-Ulrich , Koóš Peter 
Published: December 2023

AbstractThe synthesis of three enantiopure 1,2-oxazine-derived azides was optimized and the reductions of these compounds to amino alcohols were studied. As a primary aim of this study, the copper-catalyzed (3+2)-cycloadditions of the azides were investigated, employing a series of alkynes, dialkynes, and trialkynes, which afforded the corresponding mono-, di-, and trivalent triazole derivatives with different rigid and flexible core elements. The expected click products were generally obtained in good to excellent yields when copper iodide was employed in presence of tris[(1-benzyl-1H-1,2,3-triazol-4-yl)methyl]amine (TBTA) as ligand in acetonitrile at room temperature. Several of the products were subjected to exhaustive hydrogenolysis reactions, leading to enantiopure compounds with aminopyran substructures, which can be regarded as carbohydrate mimetics.
Substrate-Controlled Regioselective Alkylation of 4-Hydroxycoumarin with Diazo Compounds through TfOH Catalysis
Authors: Wang Haifeng , Xia Zhimin , Li Chunyan , Luo Mengxiang , Gu Shuangxi , Yan Qiongjiao , Lv Jian , Zeng Jie 
Published: December 2023

AbstractControl of the regioselectivity of nucleophiles toward alkylating agents is a fundamental problem in heterocyclic chemistry. Substrate-controlled TfOH-catalyzed alkylation of 4-hydroxycoumarin with diazo compounds has been developed to provide rapid access to the C3- or O-alkylated 4-hydroxycoumarins with high efficiency. The regioselectivity can be determined by varying the electronic nature of the diazo substrates, especially those bearing a methylthio group.
Avaliação funcional pós-operatória em pacientes submetidos a tratamento cirúrgico da tríade terrível do cotovelo
Authors: Amorim Anny Carolline Matutino , Dias Fábio Aguiar , Cardozo Filho Nivaldo Souza , Sousa Felipe Sodré , Alves Tasso Ribeiro , Meirelles Alexandre Vasconcelos de 
Published: December 2023

Resumo
Objetivo Avaliar os resultados funcionais dos pacientes submetidos a abordagem cirúrgica para o tratamento da tríade terrível do cotovelo, analisando os métodos de tratamento utilizados e variáveis epidemiológicas associadas.
Métodos Foram avaliados pacientes submetidos ao tratamento cirúrgico de tríade terrível do cotovelo de fevereiro de 2018 a junho de 2020 em nosso serviço. A amostra identificada foi de 17 pacientes, mas destes apenas 13 concluíram todas as etapas das pesquisas e por isso foram considerados como o universo a ser levado em consideração. Coletou–se informações epidemiológicas de interesse: idade, sexo, dominância, lado acometido, características e classificações das lesões, mecanismo do trauma, tempo para cirurgia, tipo de procedimento realizado e o arco de movimento. Foi utilizada a classificação de Mason para a fratura de cabeça do rádio e a de Regan e Morrey, para o processo coronoide. A fim de realizar uma análise funcional, aplicou-se os questionários de DASH e BRUCE.
Resultados Cerca de 77% dos pacientes foram do sexo masculino, 92% dos mecanismos de fratura foram por trauma de alta energia. Contrariamente a esta, observou-se a predominância do lado não dominante como o mais afetado. Avaliando os resultados de acordo com o tempo para início do tratamento, os pacientes operados em até 14 dias obtiveram resultados funcionais estatisticamente melhores.
Conclusão O tratamento cirúrgico da TTC gera resultados funcionais aceitáveis na maioria dos casos. O sucesso do tratamento está relacionado ao intervalo de tempo entre o trauma e a primeira cirurgia, além de se relacionar com a gravidade das lesões.
Stem Cell Secretome Modulated by Arsenicum album 30C Ameliorates Lipopolysaccharide-induced Cytokine Storm in Blood Mononuclear Cells in vitro
Authors: Aphale Parth , Sanap Avinash , Sharma Dharmendra , Kharat Avinash , Kheur Supriya , Gawade Chinmay , Somasundaram Indumati , Bhonde Ramesh 
Published: December 2023

Abstract
Background The therapeutic effectiveness of mesenchymal stem cells (MSCs) and their secretome can be enhanced by means of physical, chemical and biological preconditioning. Arsenicum album 30C (AA30) has been one of the leading homeopathic medicines used in prophylaxis against SARS-CoV-2 infection.
Aims This study aimed to investigate whether AA30 preconditioning could influence the growth factors and cytokine profile of the human dental pulp-derived MSC (DPD-MSC) secretome. Also, to test the efficacy of the AA30-preconditioned DPD-MSC secretome in ameliorating the lipopolysaccharide (LPS)-induced cytokine storm in human peripheral blood mononuclear cells (PBMCs) as an in-vitro cellular model.
Methods The cytotoxicity of AA30 was assessed in DPD-MSCs by 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide assay. Growth factors and cytokine levels in the AA30-preconditioned DPD-MSC secretome were analysed by fluorescence-activated cell sorting (FACS) analysis. The angiogenic potential of the AA30-preconditioned DPD-MSC secretome was assessed by chick yolk-sac membrane (YSM) assay. Culture medium with 0.001% ethanol was used as vehicle control. The efficacy of the AA30-preconditioned DPD-MSC secretome in ameliorating the cytokine storm was assessed in LPS pre-treated PBMCs. The mRNA and protein expression of inflammatory markers such as IL-1β, IL-6 and IL-10 were analysed by using RT-PCR and FACS analysis respectively.
Results AA30 did not exhibit cytotoxicity in the concentration range of 1% to 50%. Furthermore, the AA30-preconditioned DPD-MSC secretome exhibited a significant increase in the levels of angiogenic factors, such as human angiopoietin-2, EPO and PDGF-AA, and decreased levels of cytokines, such as TNF-α, CXCL-8 and IL-6. The AA30-preconditioned DPD-MSC secretome showed augmented angiogenesis compared to vehicle controls. The DPD-MSC secretome ameliorated LPS-induced mRNA and protein expression of IL-1β, IL-6 and IL-10 in PBMCs.
Conclusion The AA30-preconditioned DPD-MSC secretome augmented angiogenesis and ameliorated the LPS-induced cytokine storm in human PBMCs in vitro. Our data demonstrate that AA30 preconditioning enhances the therapeutic potency of MSCs and their secretome.
Matriz de competências em ortopedia e traumatologia para abordagem do sistema musculoesquelético para graduação médica
Authors: Siqueira Eduardo Martins de , Pereira Alexandre de Araújo , Oliveira Isaac Abu Kamel Marques de 
Published: December 2023

Resumo
Objetivo Construir uma matriz de competências em ortopedia e traumatologia, com enfoque no sistema musculoesquelético, necessárias ao egresso do curso de medicina no Brasil.
Método Utilizou-se a metodologia e-Delphi, visando captar a opinião de participantes de forma anônima. A primeira proposta contou com 42 itens, frutos de revisão bibliográfica e relevância epidemiológica, disponibilizados para os painelistas pelo Google Forms e enviados através do aplicativo de mensagens instantâneas Whatsapp. Constituiu-se um painel de 26 especialistas agrupados em três categorias: docentes de Ortopedia e Traumatologia, médicos da Atenção Primária e Emergencistas. O consenso foi obtido após a realização de 3 rodadas, com pelo menos 75% de concordância entre os itens inicialmente apresentados. Foram também considerados quatro indicadores: competências pré-requisito, essenciais, desejáveis e avançadas.
Resultados obteve-se uma matriz com 34 competências relativas à abordagem do sistema musculoesquelético, que contempla ações de diagnóstico e conduta de todas as faixas etárias.
Conclusão Foi construída uma matriz de competências em Ortopedia e Traumatologia para graduação médica com possibilidades de ser utilizada na sua íntegra ou de forma parcial, de acordo com o perfil do currículo institucional.
Micro CSR intervention towards employee behavioral and attitudinal outcomes: a parallel mediation model
Authors: Manzoor Sheikh Raheel , Ullah Atif , Ullah Rezwan , Khattak Afraseyab , Han Heesup , Yoo Sunghoon 
Published: December 2023

AbstractThe purpose of the study is to (a) examine the impact of perceived micro Corporate Social Responsibility (micro-CSR) on organizational (trust, justice, identification) and employee job-related behavioral and attitudinal outcomes, (b) measure the mediating influence of the organization, (justice, identification, trust) in an association among perceived micro-CSR and employee job-related behavioral and attitudinal outcomes and (c) conduct a meta-analysis about CSR and employee behavioral and attitudinal outcomes related studies. The theory of social exchange supports the parallel mediation model. Questionnaires were distributed among the senior and junior executives of cellular network companies in Pakistan. A total (n = 767) of usable questionnaires were returned cross-sectional, representing (a 92%) response rate. The collected data was first analyzed via factor analysis and measurement model estimation. A structural equation model (SEM) analyzed the parallel mediation model. Third, the PRISMA model was used to conduct a meta-analysis. The study found that perceived micro-CSR positively predicts organizational commitment and job satisfaction, whereas it negatively predicts counterproductive work behaviors (CWBs) and turnover intent. Second, it was found that the organizational (trust, justice, and identification) significantly mediates between perceived micro-CSR and commitment, satisfaction, and CWBs, whereas organization (trust, justice, and identification) insignificantly mediates between perceived micro-CSR and turnover intent. The parallel mediating framework shows that perceived CSR results in positive attitudes and behaviors. Our analysis thus offers concrete evidence encouraging businesses and administrators to be involved in CSR initiatives. The study is original, and the result of the study is valuable for all the stakeholders of business and management.
Joseph Campbell’s Oriental mythology in Ghost in the Shell (1995) and Occidental mythology in Ghost in the Shell (2017)
Authors: Li Qiao , Tan Edwin L. Phil , Yang Jianhua 
Published: December 2023

AbstractAdaptation studies in media have been carried out for decades since the 1950s. When media is adapted between different forms, the narrative inherently changes; even more so when they cross a cultural divide between Japan and the United States. That is precisely the topic of discussion between the animeGhost in the Shell(1995) and its live action film adaptationGhost in the Shell(2017). With narrative being a key focus for comparison in this article, Joseph Campbell’s Hero’s Journey is applied. Taken from his seminal workHero with a Thousand Faces, the theory of the Hero’s Journey has been the go-to reference for monomyth studies for decades which identifies the parallelism and common themes in diverse stories, from classic myths embedded in ancient cultures to film and other contemporary media based on popular culture. Yet, most studies stop there, and do not consider bringing in Campbell’s other works—namely his follow-up collection of booksThe Masks of Godwhich delves deeper into the mythologies of various regions. His books,Oriental MythologyandOccidental Mythology, zeroes in on the myths in the East and West, which would aid in conducting comparisons between materials originating from the two opposite regions, further supplementing its usefulness in adaptation studies concerning Japanese anime and their corresponding Hollywood adaptations. This article covers the changes in narrative themes corresponding to Campbell’s Oriental and Occidental mythology between the animeGhost in the Shell(1995) and its live action film adaptationGhost in the Shell(2017).
Strong dual-channel nonreciprocal radiation with guided mode resonances
Authors: Wu Jun , Qing Ye Ming 
Published: December 2023

A dual-channel thermal emitter, which is composed of an InAs layer atop an aluminum grating backed with a continuous aluminum film, is proposed and studied. Two resonant absorption and emission peaks are achieved at different wavelengths, leading to the achievement of dual-channel strong nonreciprocal radiations at two different wavelengths for an applied magnetic field of 2 T when the angle of incidence is 17°. The physical origin is revealed through illustrating the electromagnetic field distributions at both resonances and also verified through impedance matching. In addition, the perfect nonreciprocity remains stable within a wide range of structure parameters, lowering the cost of manufacture. Moreover, the nonreciprocal radiations for different incident angles and different magnetic fields are also investigated in detail. The concept and conclusions proposed here will be interesting for the development of novel energy conversion and capture devices.
An electron paramagnetic resonance study of the electron transport in heavily Si-doped high Al content AlxGa1−xN
Authors: Zvanut M. E. , Hanle Jackson P. , Paudel Subash , Page Ryan , Savant Chandrashekhar , Cho Yongjin , Xing H. Grace , Jena Debdeep 
Published: December 2023

High Al mole fraction AlGaN is an ultrawide bandgap semiconductor with potential applications in power electronics and deep UV detectors. Although n-type material is achievable with Si-doping, the role of Si is controversial, particularly for AlxGa1−xN with x &gt; 0.8. For this paper, AlGaN films were grown by plasma-assisted molecular beam epitaxy onto bulk AlN substrates and doped with 1018–1020 cm−3 Si. We examine electron transport in heavily Si-doped AlxGa1−xN with x ≥ 0.65 using magnetic resonance, which allows us to probe the neutral donors directly rather than the free carriers and avoids complications due to electrical contacts. Transport was studied through the temperature-dependent linewidth of the electron paramagnetic resonance (EPR) signature for the neutral donor. Analysis shows evidence of hopping conductivity in the most lightly doped samples and impurity band formation in the most heavily doped ones. The EPR results, which are consistent with Hall measurements performed on the same samples, are promising for the development of highly conducting high Al content AlGaN.
Effects of guanidinoacetic acid on the growth performance, meat quality, postmortem energy metabolism and muscle fibre types of finishing pigs
Authors: Li Jingzheng , Li Jiaolong , Zhang Lin , Xing Tong , Jiang Yun , Gao Feng 
Published: December 2023

Context Meat quality is increasingly being paid more attention by customers and enterprises. However, the modern pursuit of pork production has led to a decline in pork quality. Muscle fibre type is one of the important factors affecting meat quality that can be used as a key control point. Aims This study set out to assess the effects of dietary guanidinoacetic acid (GAA) on the growth performance, meat quality, postmortem energy metabolism, and muscle fibre types of finishing pigs. Methods In total, 180 healthy Duroc × Landrace × Meishan cross castrated male pigs with the similar weight (average 90 kg) were randomly divided into three treatments, with five replicates (pens) per treatment and 12 pigs per pen, including a GAA-free basal diet and basal diet with 0.05% or 0.10% GAA for 15 days. Key results In longissimus thoracis muscle, the results indicated that GAA supplementation decreased the drip loss and the cooking loss in 0.10% GAA group. Meanwhile, in semitendinosus muscle, 0.10% GAA addition increased pH45 min, and decreased the cooking loss. Additionally, GAA addition increased the content of ATP and AMP in semitendinosus muscle. The mRNA expressions of MyHC-I and MyHC-IIa were increased, whereas MyHC-IIx and MyHC-IIb were decreased. Moreover, in longissimus thoracis muscle, GAA addition promoted the mRNA expressions of CaM and NFATc1; in semitendinosus muscle, dietary GAA up-regulated the CnA and NFATc1 mRNA expressions. Conclusions GAA addition improved the meat quality, enhanced postmortem energy metabolism and promoted the conversion of fast-muscle fibre to slow-muscle fibre via activating the CaN/NFAT signalling. Implications The addition of GAA can improve the meat quality of post-slaughter finishing pigs and provide a theoretical basis for the application of GAA in livestock production.
“A ray of light in the chaos”: Relationships between companion animals and LGBTQ+ emerging adults during the COVID-19 pandemic
Authors: Matijczak Angela , Corley Nicole , Vergara Isabella , Johnson Jake , McDonald Shelby E. 
Published: December 2023

Abstract
There is evidence that pet owners experienced benefits during the COVID-19 pandemic and also struggled with pet-related stressors. Notably, almost all of these studies were conducted with predominantly cisgender and heterosexual samples. This is problematic, as evidence suggests that individuals who belong to marginalized groups, such as LGBTQ+ emerging adults, have been disproportionately affected by stressors associated with the pandemic. This qualitative study explores the unique experiences of LGBTQ+ emerging adults who lived with a pet during the COVID-19 pandemic. Additionally, we sought to identify resources needed to assist LGBTQ+ emerging adult pet owners during the pandemic. The sample included 65 participants aged 18–21 years who had lived with one or more pets within the past year (Mean age = 19.5 years; 36.9% transgender/gender diverse; 40% minoritized racial/ethnic identity). We conducted semi-structured interviews consisting of 18 questions (including five COVID-specific questions). Two authors coded and analyzed the interviews using template analysis. Then, the authors used a thematic analysis approach to organize codes into themes, identify patterns of meaning, and examine relations between themes. Four themes emerged related to the experience of living with a pet during the pandemic. Almost all participants said that their pets provided various types of support to them. Many participants stated that their pets also added stress to their lives during the pandemic. Some participants attributed the changes in their pet’s behavior and/or attitude to pandemic-related quarantines. More than half of the participants discussed changes in their relationship with their pet, with the majority claiming their relationship became stronger. Two themes emerged that related to necessary resources: greater community-based resources (e.g., low-cost veterinary care, pet-friendly outdoor spaces) and more government resources (e.g., better access to information, more material and financial support). Participants offered suggestions for ways to alleviate pet-related stressors, such as developing community-based programs (e.g., pet food pantries, mutual aid programs). There is the opportunity for collaboration between researchers and practitioners in piloting these community programs, as well as implications for policy makers to advocate for policies supportive of LGBTQ+ emerging adult pet owners (e.g., university pet policies, housing policies).