bluuebunny/crossref_metadata_2025_split huggingface dataset:
A case study of pyloric stenosis caused by metastatic lobular carcinoma of breast
Authors: Yoshida Taizo , Shimada Akihiko , Matsumoto Koichi , Inukai Michiko , Hashimoto Ryo , Matsuda Mutsuhito , Nishi Tomohiko , Seki Hiroaki , Sakata Michio , Matsumoto Hidetoshi 
Published: December 2023

Abstract
Metastasis to the gastrointestinal tract is rare. A 59-year-old woman who had a history of an invasive lobular carcinoma of breast with clinical complete response visited our hospital and complained of an upper abdominal pain and distension. We performed an upper gastrointestinal endoscopy which showed only a gastric ulcer without any malignant findings. She experienced a recurrence of symptoms 2 months after this visit. An endoscopy revealed pyloric stenosis, which did not improve with balloon dilatation. We performed a gastro-jejunal and cecal-transverse colonic bypass surgery. Diffuse wall thickening of the antrum was verified during the surgery, and a biopsy sample was collected. The diagnosis of gastric metastasis from breast was confirmed since it showed the same immunohistochemistry pattern as the prior breast lesion. Pyloric stenosis has still been confirmed with an endoscopy, she has been alive with satisfactory oral food intake for &gt;10 years.
Mechanochemical consequences of myopathy‐linked mutations in Tpm2.2 on striated muscle contractility
Authors: Küçükdogru Recep , Franz Peter , Worch Remigiusz , Robaszkiewicz Katarzyna , Siatkowska Małgorzata , Tsiavaliaris Georgios , Moraczewska Joanna 
Published: December 2023

AbstractTropomyosin (Tpm) is an actin‐binding protein central to muscle contraction regulation. The Tpm sequence consists of periodic repeats corresponding to seven actin‐binding sites, further divided in two functionally distinct halves. To clarify the importance of the first and second halves of the actin‐binding periods in regulating the interaction of myosin with actin, we introduced hypercontractile mutations D20H, E181K located in the N‐terminal halves of periods 1 and 5 and hypocontractile mutations E41K, N202K located in the C‐terminal halves of periods 1 and 5 of the skeletal muscle Tpm isoform Tpm2.2. Wild‐type and mutant Tpms displayed similar actin‐binding properties, however, as revealed by FRET experiments, the hypercontractile mutations affected the binding geometry and orientation of Tpm2.2 on actin, causing a stimulation of myosin motor performance. Contrary, the hypocontractile mutations led to an inhibition of both, actin activation of the myosin ATPase and motor activity, that was more pronounced than with wild‐type Tpm2.2. Single ATP turnover kinetic experiments indicate that the introduced mutations have opposite effects on product release kinetics. While the hypercontractile Tpm2.2 mutants accelerated product release, the hypocontractile mutants decelerated product release from myosin, thus having either an activating or inhibitory influence on myosin motor performance, which agrees with the muscle disease phenotypes caused by these mutations.
Modified Thermodilution for Simultaneous Cardiac Output and Recirculation Assessment in Veno-venous Extracorporeal Membrane Oxygenation: A Prospective Diagnostic Accuracy Study
Authors: Berger David , Stanger Elia J. , Jenni Hansjörg , Fried Philipp D. , Bachmann Kaspar F. 
Published: December 2023

Background
Thermodilution is unreliable in veno-venous extracorporeal membrane oxygenation (VV-ECMO). Systemic oxygenation depends on recirculation fractions and ratios of extracorporeal membrane oxygenation (ECMO) flow to cardiac output. In a prospective in vitro simulation, this study assessed the diagnostic accuracy of a modified thermodilution technique for recirculation and cardiac output. The hypothesis was that this method provided clinically acceptable precision and accuracy for cardiac output and recirculation.

Methods
Two ECMO circuits ran in parallel: one representing a VV-ECMO and the second representing native heart, lung, and circulation. Both circuits shared the right atrium. Extra limbs for recirculation and pulmonary shunt were added. This study simulated ECMO flows from 1 to 2.5 l/min and cardiac outputs from 2.5 to 3.5 l/min with recirculation fractions (0 to 80%) and pulmonary shunts. Thermistors in both ECMO limbs and the pulmonary artery measured the temperature changes induced by cold bolus injections into the arterial ECMO limb. Recirculation fractions were calculated from the ratio of the areas under the temperature curve (AUCs) in the ECMO limbs and from partitioning of the bolus volume (flow based). With known partitioning of bolus volumes between ECMO and pulmonary artery, cardiac output was calculated. High-precision ultrasonic flow probes served as reference for Bland–Altman plots and linear mixed-effect models.

Results
Accuracy and precision for both the recirculation fraction based on AUC (bias, −5.4%; limits of agreement, −18.6 to 7.9%) and flow based (bias, −5.9%; limits of agreement, −18.8 to 7.0%) are clinically acceptable. Calculated cardiac output for all recirculation fractions was accurate but imprecise (RecirculationAUC: bias 0.56 l/min; limits of agreement, −2.27 to 3.4 l/min; and RecirculationFLOW: bias 0.48 l/min; limits of agreement, −2.22 to 3.19 l/min). Recirculation fraction increased bias and decreased precision.

Conclusions
Adapted thermodilution for VV-ECMO allows simultaneous measurement of recirculation fraction and cardiac output and may help optimize patient management with severe respiratory failure.

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Characterization of a Cohort of Persons Who Use Methamphetamines in London, Ontario, and In-hospital Substance Use
Authors: Kim Harry H. , Silverman Michael , Anderson Kelly K. , Lodhi Rohit Jaibhagwan , Sarma Sisira , Dickey Chandlee , Forchuk Cheryl 
Published: December 2023

ABSTRACT
Our objective was to describe the sociodemographic characteristics of a cohort of people who use methamphetamine with a history of hospitalizations in London, Ontario, including their substance use patterns, health and social service use patterns, and self-perceived quality of life. Participants were recruited from community and hospital settings in Southwest Ontario, and survey data were collected between October 2020 and May 2021. A total of 109 individuals were recruited in the study, of whom 32.1% reported a hospitalization directly related to methamphetamine use and 55.0% reported using substances during a hospitalization. The survey participants had high rates of health and social service use, as well as emergency department visits. Scores for quality of life and community integration were lower for the study participants compared with general population scores. We found that in-hospital substance use was higher than reported previously, highlighting the need to address this issue to support people who use methamphetamine in the hospital setting.
Notre objectif était de décrire les caractéristiques sociodémographiques d’une cohorte de personnes consommant de la méthamphétamine et ayant des antécédents d’hospitalisation à London, en Ontario, incluant leurs habitudes de consommation de substances, leurs habitudes d’utilisation des services sociaux et de santé et leur perception de leur qualité de vie. Les participants ont été recrutés dans les milieux communautaires et hospitaliers du sud-ouest de l’Ontario, et les données de l’enquête ont été recueillies entre octobre 2020 et mai 2021. Au total, 109 personnes ont été recrutées dans l'étude. 32,1% ont déclaré une hospitalisation directement liée à la consommation de méthamphétamine, et 55,0% ont déclaré avoir consommé des substances pendant une hospitalisation. Les participants à l’enquête présentaient des taux élevés d’utilisation des services sociaux et de santé, ainsi que de visites aux urgences. Les scores de qualité de vie et d’intégration dans la communauté étaient inférieurs pour les participants à l'étude par rapport aux scores de la population générale. Nous avons constaté que la consommation de substances à l’hôpital était plus élevée que ce qui avait été rapporté précédemment, ce qui souligne la nécessité d’aborder cette question pour soutenir les personnes qui consomment de la méthamphétamine en milieu hospitalier.
Chinese expert consensus on laparoscopic hepatic segmentectomy and subsegmentectomy navigated by augmented- and mixed-reality technology combined with indocyanine green fluorescence imaging
Authors:   Hepatic Surgery Group, Surgery Branch of Chinese Medical Association, Digital Medical Branch of Chinese Medical Association, Digital Intelligent Surgery Committee of Chinese Research Hospital Association, Liver Cancer Committee of Chinese Medical Doctor Association
Published: December 2023

Abstract
Augmented- and mixed-reality technologies have pioneered the realization of real-time fusion and interactive projection for laparoscopic surgeries. Indocyanine green fluorescence imaging technology has enabled anatomical, functional, and radical hepatectomy through tumor identification and localization of target hepatic segments, driving a transformative shift in the management of hepatic surgical diseases, moving away from traditional, empirical diagnostic and treatment approaches toward digital, intelligent ones. The Hepatic Surgery Group of the Surgery Branch of the Chinese Medical Association, Digital Medicine Branch of the Chinese Medical Association, Digital Intelligent Surgery Committee of the Chinese Society of Research Hospitals, and Liver Cancer Committee of the Chinese Medical Doctor Association organized the relevant experts in China to formulate this consensus. This consensus provides a comprehensive outline of the principles, advantages, processes, and key considerations associated with the application of augmented reality and mixed-reality technology combined with indocyanine green fluorescence imaging technology for hepatic segmental and subsegmental resection. The purpose is to streamline and standardize the application of these technologies.
Opioid Use Disorder, Adolescents, and the Importance of Treatment in the Emergency Department
Authors: Buresh Chris , Kaplan Ron 
Published: December 2023

Abstract
Deaths from opiate overdoses are climbing every year, especially from fentanyl. Adolescents are particularly vulnerable to the acute and chronic harms associated with drug use, addiction, and overdose. Providers in the acute care setting have a unique opportunity to address a population of adolescents with opioid use disorder who are at the highest risk of harm and who may be more receptive to help. It is critical that providers are familiar with the tools that are available to assist and have some facility with their application.
Investigation of Two-Component Hydrogel System for the Tissue Regeneration from Simulation
Authors: Jiang Song , Kumar Ela 
Published: December 2023

AbstractTissue degenerative diseases pose significant global health challenges. Currently, hydrogel therapy stands as a promising approach to address these conditions. To explore its potential, we developed a computational simulation model to mimic hydrogel behavior accurately and precisely measure its degradation rate while incorporating dynamics associated with cell growth. This model aimed to investigate the relationship between a two-component hydrogel system and cell growth, assessing its feasibility for tissue regeneration. Our analysis revealed that the nutritional support for neural stem cells exceeds that of bone marrow cells, followed by other types of cells. This is significant considering the challenge in culturing neural stem cells compared to the relative ease of culturing other cell types. Additionally, we found that there isn’t a single solution to determine the ‘optimal’ conditions for cell growth. Different tissue regeneration processes require distinct conditions to establish what could be considered as ‘suitable’ growth environments. Lastly, it’s important to note that these ‘suitable’ conditions can be fine-tuned by adjusting various parameters.
Fine-tuning Large Language Models for Rare Disease Concept Normalization
Authors: Wang Andy , Liu Cong , Yang Jingye , Weng Chunhua 
Published: December 2023

ABSTRACTObjectiveWe aim to develop a novel method for rare disease concept normalization by fine-tuning Llama 2, an open-source large language model (LLM), using a domain-specific corpus sourced from the Human Phenotype Ontology (HPO).MethodsWe developed an in-house template-based script to generate two corpora for fine-tuning. The first (NAME) contains standardized HPO names, sourced from the HPO vocabularies, along with their corresponding identifiers. The second (NAME+SYN) includes HPO names and half of the concept’s synonyms as well as identifiers. Subsequently, we fine-tuned Llama2 (Llama2-7B) for each sentence set and conducted an evaluation using a range of sentence prompts and various phenotype terms.ResultsWhen the phenotype terms for normalization were included in the fine-tuning corpora, both models demonstrated nearly perfect performance, averaging over 99% accuracy. In comparison, ChatGPT-3.5 has only ∼20% accuracy in identifying HPO IDs for phenotype terms. When single-character typos were introduced in the phenotype terms, the accuracy of NAME and NAME+SYN is 10.2% and 36.1%, respectively, but increases to 61.8% (NAME+SYN) with additional typo-specific fine-tuning. For terms sourced from HPO vocabularies as unseen synonyms, the NAME model achieved 11.2% accuracy, while the NAME+SYN model achieved 92.7% accuracy.ConclusionOur fine-tuned models demonstrate ability to normalize phenotype terms unseen in the fine-tuning corpus, including misspellings, synonyms, terms from other ontologies, and laymen’s terms. Our approach provides a solution for the use of LLM to identify named medical entities from the clinical narratives, while successfully normalizing them to standard concepts in a controlled vocabulary.
Intratumor bacteria is associated with prognosis in clear-cell renal cell carcinoma
Authors: Li Yuqing , Zhang Dengwei , Tan Linyi , Xu Junyao , Guo Ting , Sun Yang , Zhang Rui , Cheng Yao , Jiang Haowen , Zhai Wei , Li Yong-xin , Feng Chenchen 
Published: December 2023

ABSTRACTBackgroundIntratumor bacteria (ITB) plays a role in various cancer types. Its role in clear-cell renal cell carcinoma (ccRCC) remains elusive due to small sample size and inadequate decontamination in relevant studies.ObjectiveTo establish common and reproducible ITB-associated biomarkers in ccRCC.Design, setting, and participantsThis retrospective study comprised seven bulk RNA sequencing datasets from six publicly available cohorts and one in-house Chinese cohort (Renji), one 16S rRNA sequencing dataset from an original Chinese cohort (Huashan), and one publicly available single-cell RNA sequencing dataset. All of these datasets included ccRCC cases.Outcome measurements and statistical analysisComposition was presented by relative abundance. Overall and progression-free survival were primary outcomes profiled by putative ITB load and risk score, respectively. Potential host interaction was exploratorily analyzed using gene set enrichment analysis and Sparse CCA.Results and limitationsNine cohorts encompassing a total of 1049 ccRCC cases and 130 paired normal tissues were initially analyzed and underwent decontamination. Surprisingly, neither diversity nor composition was differentially distributed between normal and cancer tissue. High putative bacterial load was associated with better overall survival. Notably, a 7-genera dichotomized ITB risk score was indicative of overall survival and a 13-genera dichotomized ITB risk score was predictive of progression-free survival, respectively.Actinomyces,RothiaandBifidobacteriumshowed a protective role whileExiguobacteriumwas a risk factor. A limitation is lack of causation analyses.ConclusionsITB exists in ccRCC. High ITB loads and ITB-risk score predicts better ccRCC survival regardless of sequencing tech, sample processing or racial disparity.Patient SummaryIn this report, we explored the role of intratumor bacteria (ITB) in renal clear-cell carcinoma (ccRCC) in patients with different race and sequencing platforms. Putative ITB load and a 7-genera ITB risk score were associated with overall survival. A 13-genera ITB risk score was predictive of progression-free survival. We conclude that certain ITB features are universally pathogenic to ccRCC.
Academic librarians’ perceptions of mobile technology’s usefulness in library service delivery at universities of technology in South Africa
Authors: Matumba Muvhulawa , Rajkoomar Mogiveny 
Published: December 2023

Purpose
Globally, mobile technology is a significant factor influencing how libraries are changing the ways of delivering services to today’s users. This paper aims to explore academic librarians’ perceptions of the usefulness of mobile technology in delivering library services and the efforts required for its successful adoption.

Design/methodology/approach
The study was conducted within an interpretive paradigm. The research objectives were underpinned by the unified theory of acceptance and use of technology as a theoretical framework. Data were collected through semi-structured interviews and analyses using NVIVO for thematic analysis.

Findings
Results show that, in general, academic librarians support the use of mobile technology to provide services such as access to eBooks and Journals, Online Public Access Catalogue, Bookmyne application, information literacy consultations and training. Library managers, fellow librarians and users were identified as encouraging the adoption of mobile technology to enhance library services. The paper further confirms that the successful adoption of mobile technology requires some effort. However, due to some of the challenges presented in the study, a majority of respondents felt that their libraries are not yet ready to fully embrace mobile technology the way it is envisioned in today’s world.

Practical implications
The study endeavours to address the divergence between students and academic librarians’ viewpoints regarding the application of mobile technology in the provision of library services.

Originality/value
This paper highlights numerous ways that academic librarians could adopt and embrace mobile technology, which can benefit both academic libraries and other institutions of higher learning. The knowledge presented in this paper could assist academic librarians in assessing their institutions’ vulnerabilities, challenges and strengths in using mobile technologies to provide library services.
The Frailty, Health and Care Needs Assessment (FHCNA): development of the questionnaire and testing its feasibility in homeless hostel accommodation
Authors: Shulman Caroline , Rogans-Watson Rafi , Palipane Natasha , Lewer Dan , Yeung Michelle , Hudson Briony F. 
Published: December 2023

PurposeThis study aims to co-develop a Frailty, Health and Care Needs Assessment (FHCNA) questionnaire for people experiencing homelessness and explore the feasibility of its use by non-clinical staff in homeless hostels.Design/methodology/approachThe FHCNA, aimed at identifying frailty and other health and care priorities for people experiencing homelessness, was co-designed in workshops (online and in person) with homelessness and inclusion health staff. Its feasibility was tested by staff and their clients in two hostels, with pre- and post-study focus groups held with hostel staff to gain input and feedback.FindingsThe FHCNA was co-developed and then used to collect 74 pairs of resident and key worker inputted data (62% of eligible hostel residents). The mean age of clients was 48 years (range 22–82 years). High levels of unmet need were identified. Over half (53%) were identified as frail. Common concerns included difficulty walking (46%), frequent falls (43%), chronic pain (36%), mental health issues (57%) and dental concerns (50%). In total, 59% of clients reported difficulty in performing at least one basic activity of daily living, while only 14% had undergone a Care Act Assessment. Hostel staff found using the FHCNA to be feasible, acceptable and potentially useful in facilitating explorations of met and unmet health and social care needs of hostel clients. By identifying unmet needs, the FHCNA has the potential to support staff to advocate for access to health and social care support.Originality/valueTo the best of the authors’ knowledge, this is the first study to co-develop and feasibility test a questionnaire for use by non-clinically trained staff to identify frailty and other health and care needs of people experiencing homelessness in a hostel setting.
The impact of TQM practices on organizational performance and on innovation: the mediating role of organizational learning
Authors: Tajouri Oumayma , Lakhal Lassaad 
Published: December 2023

PurposeThis article examines the direct effect of total quality management (TQM) practices on organizational performance (OP) and innovation (INN), as well as their indirect effect through organizational learning (OL) as a mediating variable. In addition, this survey examines company size as a contextual variable in the relationship between TQM and outcome variables.Design/methodology/approachA conceptual framework is proposed to test causal links between TQM, OP, INN and OL. To empirically test this framework, 110 questionnaires were collected from large Tunisian quality-certified industries, and 167 questionnaires were collected from small and medium-sized industries (SMIs) in order to examine the effect of company size. In this order, a multigroup analysis (MGA) is performed.FindingsUsing the structural equation modeling technique, seven hypotheses are investigated. The results reveal that TQM has a direct and significant positive effect on OP and INN. Data analysis shows that there is a significant positive effect between TQM and OL, while OL positively influences OP and INN. Furthermore, the results illustrate a mediating effect of OL between TQM and OP and INN. The results reveal that large industries and SMIs show significant differences in the relationship, including the conceptual model.Practical implicationsThe conceptual framework can be used by practitioners for effective implementation of TQM practices to simultaneously improve operational performance, quality performance and INN. This study also focuses on the role of OL in large-scale industries.Originality/valueWhile the relationships between TQM, INN and OP have been examined separately in previous studies, this study examines the relationship between these variables in a unique model in Tunisian industries, including OL as a mediating variable. In addition, it is one of the few studies that considers firm size as a contextual variable and provides an analysis of its effect on the relationships between these variables. This study presents new data and empirical insights into the relationship between these variables.