bluuebunny/crossref_metadata_2025_split huggingface dataset:
The influence of openness to change on academics' research publication in public higher education institutions in Tanzania
Authors: Ndiango Sinyati , Kumburu Neema P. , Jaffu Richard 
Published: November 2023

PurposeThe major purpose of this paper is to examine the influence of openness to change on research publication in higher education institutions (HEI) in Tanzania.Design/methodology/approachWith a sample of 247 academics, a cross-sectional survey design was used and questionnaires were the primary data collection tool. The collected data were tested using mean and standard deviations, and the causal–effect relationship between the independent and dependent variables was tested using simple linear regression.FindingsThe findings of this study revealed that openness to change positively and significantly influence research publication in higher education (β = 0.598 and p < 0.001).Practical implicationsThe study recommends that HEI should consider openness to change value as one among criteria for hiring academics as well as developing good programs that will help academics develop the academics' self-awareness with regard to what takes for one to be a productive researcher.Originality/valueThis is the first study to examine the influence of openness to change as a personal value on academics’ research publication in Tanzanian HEI. In this instance, the study contributes to the existing literature on the influence of academics' personal values in terms of openness to change on research publication.
How true is the truth? A study of the factors affecting honest response behaviour of patients in hospital settings
Authors: Darzi Mushtaq Ahmad , Islam Sheikh Basharul , Bhat Suhail Ahmad , Khursheed Syed Owais 
Published: November 2023

Purpose The current study is aimed at identifying the prominent influencers that affect the response behaviour of patients in a hospital environment.Design/methodology/approach The research is based on the data collected through the participant observation method while interviewing patients about the quality of healthcare services in nine community health centres of the Kashmir division. Thematic analysis was performed on the information collected from patients admitted to various hospital sections.Findings The analysis of the qualitative data revealed that the presence of hospital staff near respondents, perceived risk of maltreatment, social desirability, the sensitivity of the topic, risk of information sharing and attitude towards surveys are the most frequently observed factors that modulate the patient's tendency to truthfully report critical facts about the problem understudy.Originality/value These results can help researchers to exercise caution while communicating with respondents and collecting data related to serious issues in a natural setting.
Skeletal muscle DNA methylation: Effects of exercise and HIV
Authors: Jankowski Catherine M. , Konigsberg Iain R. , Wilson Melissa P. , Sun Jing , Brown Todd T. , Julian Colleen G. , Erlandson Kristine M. 
Published: November 2023

AbstractAging, human immunodeficiency virus (HIV) infection, and antiretroviral therapy modify the epigenetic profile and function of cells and tissues, including skeletal muscle (SkM). In some cells, accelerated epigenetic aging begins very soon after the initial HIV infection, potentially setting the stage for the early onset of frailty. Exercise imparts epigenetic modifications in SkM that may underpin some health benefits, including delayed frailty, in people living with HIV (PWH). In this first report of exercise‐related changes in SkM DNA methylation among PWH, we investigated the impact of 24 weeks of aerobic and resistance exercise training on SkM (vastus lateralis) DNA methylation profiles and epigenetic age acceleration (EAA) in older, virally suppressed PWH (n = 12) and uninfected controls (n = 18), and associations of EAA with physical function at baseline. We identified 983 differentially methylated positions (DMPs) in PWH and controls at baseline and 237 DMPs after training. The influence of HIV serostatus on SkM methylation was more pronounced than that of exercise training. There was little overlap in the genes associated with the probes most significantly differentiated by exercise training within each group. Baseline EAA (mean ± SD) was similar between PWH (−0.4 ± 2.5 years) and controls (0.2 ± 2.6 years), and the exercise effect was not significant (p = 0.79). EAA and physical function at baseline were not significantly correlated (all p ≥ 0.10). This preliminary investigation suggests HIV‐specific epigenetic adaptations in SkM with exercise training but confirmation in a larger study that includes transcriptomic analysis is warranted.
Phenotypic variability in Joubert syndrome is partially explained by ciliary pathophysiology
Authors: Owens Joshua w. , Hopkin Robert J. , Martin Lisa J. , Kodani Andrew , Simpson Brittany N. 
Published: November 2023

AbstractIntroduction: Joubert syndrome (JS) arises from defects of primary cilia resulting in potential malformations of the brain, kidneys, eyes, liver, and limbs. Several of the 35+ genes associated with JS have recognized genotype/phenotype correlations, but most genes have not had enough reported individuals to draw meaningful conclusions.Methods: A PubMed literature review identified 688 individuals with JS across 32 genes and 112 publications to bolster known genotype/phenotype relationships and identify new correlations.All included patients had the “molar tooth sign” and a confirmed genetic diagnosis. Individuals were categorized by age, ethnicity, sex and the presence of developmental disability/intellectual disability, hypotonia, abnormal eye movements, ataxia, visual impairment, renal impairment, polydactyly, and liver abnormalities.Results: Most genes demonstrated unique phenotypic profiles. Grouping proteins based on physiologic interactions established stronger phenotypic relationships that reflect known ciliary pathophysiology. Age‐stratified data demonstrated that end‐organ disease is progressive in JS. Most genes demonstrated a significant skew towards having variants with either residual protein function or no residual protein function.Conclusion: This cohort demonstrates that clinically meaningful genotype/phenotype relationships exist within most JS‐related genes and can be referenced to allow for more personalized clinical care.
Energy Storage and Environmental Justice: A Critical Examination of a Proposed Pumped Hydropower Facility in Goldendale, Washington
Authors: Cantor Alida , Turley Bethani , Maxfield Katie 
Published: November 2023

AbstractRenewable energy sources such as solar and wind produce electricity intermittently, creating challenges in balancing electricity supply and demand for increasingly renewable‐dominated grids. This is driving efforts to increase energy storage infrastructure, such as pumped hydroelectric power storage (pumped storage). In this research, we examine environmental justice issues in a case study of a proposed pumped storage facility in Goldendale, Washington, which has been highly controversial and actively contested by a coalition of Indigenous and environmental communities. Drawing from frameworks of political ecology, just transitions, and Indigenous environmental justice, we focus on processes of consultation and engagement around permitting as a key arena for environmental justice contestation, and critically examine the driving assumptions behind the project. Despite popular framings of renewable energy infrastructures as new and green, we argue that the environmental justice impacts of this and similar projects represent continuity with past patterns of settler colonialism and extractive development.
Druggable site near the upper vestibule determines the high affinity and P2X3 homotrimer selectivity of sivopixant/S‐600918 and its analogue DDTPA
Authors: Wang Dong‐Ping , Zhang Meng , Li Ming , Yang Xiao‐Na , Li Changzhu , Cao Peng , Zhu Michael X. , Tian Yun , Yu Ye , Lei Yun‐Tao 
Published: November 2023

Background and PurposeThe P2X3 receptor, a trimeric ionotropic purinergic receptor, has emerged as a potential therapeutic target for refractory chronic cough (RCC). Nevertheless, gefapixant/AF‐219, the only marketed P2X3 receptor antagonist, might lead taste disorders by modulating the human P2X2/3 (hP2X2/3) heterotrimer. Hence, in RCC drug development, compounds exhibiting strong affinity for the hP2X3 homotrimer and a weak affinity for the hP2X2/3 heterotrimer hold promise. An example of such a molecule is sivopixant/S‐600918, a clinical Phase II RCC candidate with a reduced incidence of taste disturbance compared to gefapixant. Sivopixant and its analogue, (3‐(4‐([3‐chloro‐4‐isopropoxyphenyl]amino)‐3‐(4‐methylbenzyl)‐2,6‐dioxo‐3,6‐dihydro‐1,3,5‐triazin‐1(2H)‐yl)propanoic acid (DDTPA), exhibit both high affinity and high selectivity for hP2X3 homotrimers, compared with hP2X2/3 heterotrimers. The mechanism underlying the druggable site and its high selectivity remains unclear.Experimental ApproachTo analyse mechanisms that distinguish this drug candidate from other inhibitors of the P2X3 receptors we used a combination of chimera construction, site covalent occupation, metadynamics, mutagenesis and whole‐cell recording.Key ResultsThe high affinity and selectivity of sivopixant/DDTPA for hP2X3 receptors was determined by the tri‐symmetric site located close to the upper vestibule. Substitution of only four amino acids inside the upper body domain of hP2X2 with those of hP2X3, enabled the hP2X2/3 heterotrimer to exhibit a similar level of apparent affinity for sivopixant/DDTPA as the hP2X3 homotrimer.Conclusion and ImplicationsFrom the receptor‐ligand recognition perspective, we have elucidated the molecular basis of novel RCC clinical candidates' cough‐suppressing properties and reduced side effects, offering a promising approach to the discovery of novel drugs that specifically target P2X3 receptors.
Sex‐specific causality of MRI‐derived body compositions on glycaemic traits: Mendelian randomization and observational study
Authors: Zhu Yijie , Wang Qi , Dai Huajie , Hou Tianzhichao , Wang Tiange , Zhao Zhiyun , Li Mian , Miao Wei , Yang Jian , Lu Jieli , Xu Yu , Chen Yuhong , Ning Guang , Zheng Jie , Bi Yufang , Xu Min , Wang Weiqing 
Published: November 2023

AbstractAimTo investigate the sex‐specific causality of body compositions in type 2 diabetes and related glycaemic traits using Mendelian randomization (MR).Materials and MethodsWe leveraged sex‐specific summary‐level statistics from genome‐wide association studies for three adipose deposits adjusted for body mass index and height, including abdominal subcutaneous adipose tissue, visceral adipose tissue (VATadj) and gluteofemoral adipose tissue (GFATadj), measured by MRI (20 038 women; 19 038 men), and fat mass‐adjusted appendicular lean mass (ALMadj) (244 730 women; 205 513 men) in the UK Biobank. Sex‐specific statistics of type 2 diabetes were from the Diabetes Genetics Replication and Meta‐analysis Consortium and those for fasting glucose and insulin were from the Meta‐analyses of Glucose and Insulin‐related Traits Consortium. Univariable and multivariable MR (MVMR) were performed. We also performed MR analyses of anthropometric traits and genetic association analyses using individual‐level data of body composition as validation.ResultsUnivariable MR analysis showed that, in women, higher GFATadj and ALMadj exerted a causally protective effect on type 2 diabetes (GFATadj: odds ratio [OR] 0.59, 95% confidence interval [CI; 0.50, 0.69]; ALMadj: OR 0.84, 95% CI [0.77, 0.91]) and VATadj to be riskier in glycaemic traits. MVMR showed that GFATadj retained a robust effect on type 2 diabetes (OR 0.57, 95% CI [0.42, 0.77]; P = 2.6 × 10−4) in women, while it was nominally significant in men (OR 0.58, 95% CI [0.35, 0.96]; P = 3.3 × 10−2), after adjustment for ASATadj and VATadj. MR analyses of anthropometric measures and genetic association analyses of glycaemic traits confirmed the results.ConclusionsBody composition has a sex‐specific effect on type 2 diabetes, and higher GFATadj has an independent protective effect on type 2 diabetes in both sexes.
Effects of maternal pulmonary arterial hypertension on fetal hemodynamics and maternal‐fetal outcome in late pregnancy
Authors: Xing Yuan Yuan , Ruan Yanping , Qin Huai , Zhao Lei , Zhao Qing , Wei Yun , Chen Jie , Ma Xiaohai 
Published: November 2023

AbstractPurposeThe aim of this study was to investigate the effects of maternal pulmonary arterial hypertension (PAH) on fetal hemodynamics in the third trimester and to identify hemodynamic indicators associated with adverse maternal and fetal outcomes.MethodsWe recruited 48 pregnant women with PAH in the third trimester and 32 women with normal pregnancies as controls matched for age and gestational week. Fetal growth and hemodynamic parameters were assessed by two‐dimensional and color Doppler. All cases were followed up until delivery and maternal and fetal outcomes were collected. High throughput sequencing method was used to determine differential miRNA patterns in plasma exposed to pulmonary arterial hypertension (PAH) in pregnant women. We then performed the validated of key differentially expressed miRNAs by real‐time PCR.ResultsCompared with the normal and mild PAH groups, resistance index (RI), pulsatility index (PI) of the fetal umbilical artery (UA) and quantitative ductus venosus (QDV) blood flow were increased in subjects with moderate to severe PAH, while PI and the ratio of peak systolic velocity (PSV) to end‐diastolic velocity (EDV) (S/D) of the middle cerebral artery (MCA) were decreased. Compared with the normal group, subjects in the mild and moderate PAH groups had lower neonatal weight, shorter neonatal height, and higher preterm birth rates. In addition, miRNA sequencing data showed that PAH affected the levels of 23 miRNAs in plasma. At the same time, we showed that PAH significantly decreased the level of miR‐1255a and increased the level of miR‐548ar‐3p by real‐time PCR.ConclusionIn the group of pregnant women with moderate to severe pulmonary hypertension, there was a higher proportion of preterm births and low birth weight babies. Hemodynamic changes in the fetal UA, MCA, and ductus venosus (DV) during late pregnancy were associated with adverse fetal outcomes. At the same time, miRNA sequencing results showed that miR‐1255a and miR‐548ar‐3p may play an important role in the development of PAH.
Role of echocardiography in the management of ventricular septal rupture after acute myocardial infarction
Authors: Baltodano‐Arellano Roberto , Cupe‐Chacalcaje Kelly , Cachicatari‐Beltran Angela , Benites‐Yshpilco Lindsay , Urdanivia‐Ruiz Dante , Moscoso Josh , Rojas Paol , Ortiz‐Leon Xochitl , Levano‐Pachas Gerald 
Published: November 2023

AbstractVentricular septal rupture (VSR) is a rare and devastating complication of acute myocardial infarction. Early detection, assessment of the hemodynamic impact, and illustration of the pathophysiological context are crucial functions of echocardiography in decision‐making for intensive management and reparative intervention. To evaluate this entity, echocardiography exhibits two strengths: its bedside nature and its multiple modalities. This document reviews the comprehensive use of echocardiography in the study of post‐infarction VSR.
Biodiversity connections—‘ties that bind’
Authors: Freeman Mary C. , Elkins Duncan , Albanese Brett 
Published: November 2023

AbstractConnectivity is a foundational concept in ecology and conservation and was the organising theme for the 2022 Annual Meeting of the Southeastern Fishes Council, a professional organisation dedicated to the study and conservation of freshwater fishes native to the southeast region of the United States (US). We introduce a Special Contribution of five papers selected from presentations at that meeting that illustrate perspectives on connections created by fish migration and dispersal, evolved life histories and habitat affinities and interspecific facilitation. Although focused on streams of the southeast US, each of these topics is broadly relevant to freshwater fish conservation, particularly with respect to causes and consequences of migratory fish depletion, population fragmentation and species declines. Many other connections relevant to the ecology and conservation of freshwater fishes remain relatively unexplored but could substantively advance conservation. We highlight the potential that species evolutionary histories, that is connections through time, reconstructed using species distributions and phylogenies may improve predictions of species responses to environmental change. Identifying species interdependencies, including undiscovered interactions that support survival or reproduction, could provide insights into how species losses may cascade as aquatic communities unravel. Finally, efforts to elucidate diverse connections between people and freshwater biodiversity, particularly where fisheries are historic and streams mostly go unnoticed, may prove essential to building public support for conservation measures. A research agenda anchored on ‘biodiversity connections’ has the potential to advance ecological understanding and public engagement, elements essential to conserving freshwater fishes.
Hypersomnia in anti‐glutamic acid decarboxylase 65 (GAD65) associated neurological syndromes: A pilot study
Authors: Jeantin Lina , Gales Ana , Berzero Giulia , Leu Smaranda , Proust Jérémy , Giry Marine , Valyraki Nefeli Eirini , Birzu Cristina , Alentorn Agusti , Vidailhet Marie , Psimaras Dimitri , Arnulf Isabelle 
Published: November 2023

AbstractBackground and purposeDespite their detrimental impact on the quality of life in autoimmune encephalitis, sleep disorders have not been investigated in anti‐glutamic acid decarboxylase (GAD65) associated neurological syndromes.MethodsSix consecutive adult patients diagnosed with anti‐GAD65‐associated neurological syndromes (four with limbic encephalitis and two with stiff‐person syndrome) and 12 healthy controls were enrolled. Participants underwent sleep interviews and sleep studies including night‐time video‐polysomnography, followed by five daytime multiple sleep latency tests (MSLTs, to assess propensity to fall asleep) and an 18 h bed rest polysomnography (to assess excessive sleep need).ResultsPatients reported the need for daily naps and that their cognition and quality of life were altered by sleepiness, but they had normal scores on the Epworth sleepiness scale. Compared with controls, sleep latencies during the MSLT were shorter in the patient group (median 5.8 min, interquartile range [IQR] 4.5, 6.0 vs. 17.7 min, IQR 16.3, 19.7, p = 0.001), and the arousal index was reduced (2.5/h, IQR 2.3, 3.0 vs. 22.3/h, IQR 13.8, 30.0, p = 0.002), although total sleep time was similar between groups (621 min, IQR 464, 651 vs. 542.5 min, IQR 499, 582, p = 0.51). Remarkably, all six patients had MSLT latencies ≤8 min, indicating severe sleepiness. No parasomnia or sleep‐disordered breathing was detected.ConclusionCentral hypersomnia is a relevant characteristic of anti‐GAD65‐associated neurological syndromes.
Commentary: Holy grails, personalized medicine, and the public health burden of psychopathology – a reflection on Ahuvia et al. (2023)
Authors: Lorenzo‐Luaces Lorenzo 
Published: November 2023

Clinical psychology and psychiatry have many ‘holy grails’ or research findings that are widely sought after but remain elusive. The use of machine learning (ML) models for treatment selection is one of these holy grails. Ahuvia et al. (Journal of Child Psychology and Psychiatry, 2023) recently analyzed a large trial (n = 996) of two distinct single‐session interventions (SSIs) for internalizing distress and found little evidence that an ML model could predict differential treatment response. I discuss potential avenues for advancing SSI research. One avenue is the dissemination and implementation of SSIs, including how they interact with other treatments in routine care. Quantifying and critically questioning the promises of holy grails like ML models is sorely needed. Using simulation modeling to evaluate the relative merits of using ML models for treatment selection or using SSIs versus other treatment strategies may be another path forward.
Attention challenges in Kabuki syndrome
Authors: Kalinousky A. J. , Rapp T. , Harris J. R. 
Published: November 2023

AbstractBackgroundUnderstanding the specific neurobehavioural profile of rare genetic diseases enables clinicians to provide the best possible care for patients and families, including prognostic and treatment advisement. Previous studies suggested that a subset of individuals with Kabuki syndrome (KS), a genetic disorder causing intellectual disability and other neurodevelopmental phenotypes, have attentional deficits. However, these studies looked at relatively small numbers of molecularly confirmed cases and often used retrospective clinical data instead of standardised assessments.MethodsFifty‐five individuals or caregivers of individuals with molecularly confirmed KS completed assessments to investigate behaviour and adaptive function. Additionally, information was collected on 23 unaffected biological siblings as controls.ResultsAttention Problems in children was the only behavioural category that, when averaged, was clinically significant, with the individual scores of nearly 50% of the children with KS falling in the problematic range. Children with KS scored significantly higher than their unaffected sibling on nearly all behavioural categories. A significant correlation was found between Attention Problems scores and adaptive function scores (P = 0.032), which was not explained by lower general cognitive ability.ConclusionsWe found that the rates of children with attentional deficits are much more elevated than would be expected in the general population, and that attention challenges are negatively correlated with adaptive function. When averaged across KS participants, none of the behavioural categories were in the clinically significant range except Attention Problems for children, which underscores the importance of clinicians screening for attention deficit hyperactivity disorder (ADHD) in children with KS.
Protocolo para Julgamento com Perspectiva de Gênero
Authors: Cirino Samia Moda , Feliciano Julia 
Published: November 2023

O artigo objetiva verificar o efeito do Protocolo para julgamento com perspectiva de gênero do CNJ para enfrentamento da violência de gênero relativamente às teses levadas ao Judiciário pelos profissionais do Direito. O problema de pesquisa consiste em verificar se o Protocolo permitirá que os sujeitos do processo observem as questões de gênero e a forma que devem ser enfrentadas no trâmite e julgamento das demandas nos diversos ramos do Judiciário. Para responder essa questão, é analisada a primeira parte do Protocolo para verificar se os conceitos, teorias e metodologias adotadas para inserção da perspectiva feminista no âmbito da atividade jurisdicional são adequadas. Essa análise qualitativa, pautada pela metodologia feminista, permite uma primeira conclusão, de que o Protocolo deve passar por revisão de um grupo de trabalho plural, de modo a abranger todos os atores da atividade jurisdicional e em razão de apresentar equívocos teóricos e metodológicos. Em seguida, tendo como referencial os feminismos decoloniais, desenvolve a hipótese de necessidade de uma ruptura epistemológica do próprio Direito e da reconstrução do conhecimento e prática jurídica para efetivo enfrentamento da violência de gênero. Diante dessas análises, conclui que, mesmo se necessária uma revisão plural, o Protocolo é aplicável, tem caráter cogente e deve ser articulado com estratégias de ensino-aprendizagem que insiram a perspectiva dos feminismos nas grades curriculares de formação dos profissionais do Direito no Brasil. Os resultados obtidos permitem a formulação de propostas concretas para o enfrentamento da violência de gênero na atividade jurisdicional, caracterizando a pesquisa como tecnologia social.

PALAVRAS-CHAVE: Feminismos; Epistemologia; Decolonial; Relações de gênero; Práxis Jurídica.