bluuebunny/crossref_metadata_2025_split huggingface dataset:
Tuning Drafting Zone Parameters for Polyester Yarn within a Ring Spinning System: Modeling and Optimization
Authors: Savadroodbari Habib Amiri , Razbin Milad , Hasani Mohsen Reza , Johari Majid Safar 
Published: October 2023

Abstract
Most textile products incorporate yarn as a fundamental element in the production process. Among various yarn manufacturing methods, the ring spinning system stands out as a crucially employed technology due to its advantages including yarn quality, evenness, low hairiness, and ease of handling. The parameters of drafting zone in this technology have a great impact on the quality of yarns. Typically, tuning this drafting zone parameters is time-consuming and costly through trial and error method. This study introduces an algorithmic procedure based on response surface methodology (RSM), experimental modeling, and multi-objective optimization to reduce unevenness percentage (U%) and imperfection index (IPI). Input parameters, including cots hardness of front and back top rollers, spacer size, and break draft, are optimized. Results indicate superior prediction performance of the artificial neural network (ANN) (average vaule of TGF = 1.9996) compared to RSM (average value of TGF = 1.8668). Consequently, ANN is selected for optimization. Furthermore, coupling the genetic algorithm with two ANN-based models reduced IPI from 39 to 33.67 and a reduction from 9.73–9.67% occurred in terms of U%. The final setting of Input parameters were cots hardness of front roller of 70 shore and cots hardness of back roller of 76 shore, spacer size 2.8 mm, and break draft of 1.26. This method efficiently optimizes the drafting zone parameter, enhancing yarn quality.
Extrusion-based Additive Manufacturing of Three-dimensional MoSe2-nanosheet-coated TiO2 Hetero-structures for Photocatalytic CO2 Reduction
Authors: Oh Heungseok , Charles Hazina , Im Taehyeob , Khan Haritham , Lee Sunyong 
Published: October 2023

Abstract
Extrusion-based additive manufacturing (EAM) provides design freedom and facilitates the production of complicated structures that are often challenging to produce using conventional processing methods. In this study, a TiO2 feedstock was developed by mixing TiO2 with a binder and optimized for extrusion. To maximize the reaction efficiency, we fabricated three-dimensional (3D) structures for photocatalytic CO2 reduction based on the designed model. To further enhance the photocatalytic CO2 reduction efficiency, we introduced a heterostructure by hydrothermally synthesizing MoSe2, a transition metal dichalcogenide (TMD), on the TiO2 surface. MoSe2, which is known for its affordability in fabrication heterostructures, high electrical conductivity, expanded light absorption range, and reduced bandgap, has the potential to enhance photocatalytic efficiency. The effectiveness of various TiO2–MoSe2 3D structural designs for CO2 reduction was evaluated. A custom-made stainless-steel reactor was used for CO2 reduction under UV-vis irradiation, followed by gas chromatography analysis of the produced gases. The optimized structure exhibited remarkable CO2 selectivity, reaching approximately 82%, demonstrating the feasibility of using EAM for fabricating 3D structures for photocatalytic CO2 reduction.
Generation of iPSC lines (KAIMRCi003A, KAIMRCi003B) from a Saudi patient with Dravet Syndrome carrying homozygous mutation in the CPLX1 gene and heterozygous mutation in SCN9A
Authors: Alowaysi Maryam , Al-Shehri Mohammad , Badkok Amani , ATTAS HANOUF , Aboalola Doaa , Baadhaim Moayad , Alzahrani Hajar , Daghestani Mustafa , Zia Asima , Al-Ghamdi Khalid , Al-Ghamdi Asayil , Zakri Samer , AOUABDI SIHEM , Tegner Jesper , Alsayegh Khaled 
Published: October 2023

Abstract
The most prevalent form of epileptic encephalopathy is Dravet Syndrome (DRVT), which is triggered by the pathogenic variant SCN1A in 80% of cases. iPSCs with different SCN1A mutations have been constructed by several groups to model DRVT syndrome. However, no studies involving DRVT-iPSCs with rare genetic variants have been conducted. Here, we established two DRVT-iPSC lines harboring a homozygous mutation in the CPLX1 gene and heterozygous mutation in SCN9A gene. Therefore, the derivation of these iPSC lines provides a unique cellular platform to dissect the molecular mechanisms underlying the cellular dysfunctions consequent to CPLX1 and SCN9A mutations.
Oral Health Outcomes In An HIV Cohort With Comorbidities- Implementation Roadmap For A Longitudinal Prospective Observational Study
Authors: Omolehinwa Temitope , Akintoye Sunday O. , Gabinskiy Marta , Re Vincent Lo , Mupparapu Mel , Urbina Rosa , Schaubel Douglas E. , Corby Patricia 
Published: October 2023

Abstract
Long-term antiretroviral therapy (ART) perpetually suppresses HIV load and has dramatically altered the prognosis of HIV infection, such that HIV is now regarded as a chronic disease. Side effects of ART in Patients With HIV (PWH), has introduced new challenges including “metabolic” (systemic) and oral complications. Furthermore, inflammation persists despite great viral load suppression and normal levels of CD4+ cell count.
The impact of ART on the spectrum of oral diseases among PWH is often overlooked relative to other systemic complications. There is paucity of data on oral complications associated with ART use in PWH. This is in part due to limited prospective longitudinal studies designed to better understand the range of oral abnormalities observed in PWH on ART. Our group designed and implemented a prospective observational longitudinal study to address this gap.
We present a procedural roadmap that could be modelled to assess the extent and progression of oral diseases associated with ART in PWH. We described here the processes associated with subject recruitment and retention, study visit planning, oral health assessments, bio-specimen collection and preprocessing procedures, and data management. We also highlighted the rigors and challenges associated with participant recruitment and retention.
Sleep Related Breathing Disorders in Infants with Spina Bifida Repaired Prenatally and Postnatally
Authors: Stark Katherine G. , Smith Kathryn A. , Wang Rachel Y. , Keens Thomas G. , Speybroeck Alexander , Chmait Ramen H. , Ward Sally L. Davidson , Chu Jason , Perez Iris A. 
Published: October 2023

Abstract

Purpose: Recent advances in prenatal repair of myelomeningocele (MMC) have improved outcomes involving different organ systems. There is limited data on respiratory outcomes following prenatal surgical repair. We hypothesize there is no difference in respiratory outcomes between spina bifida (SB) patients who have undergone prenatal versus postnatal repair.
Methods: Retrospective study of 46 infants <1 year with SB seen at Children's Hospital Los Angeles from 2004-2022. Demographic data, timing of closure, neonatal course, Chiari II malformation (CIIM), ventriculoperitoneal shunt (VPS), polysomnography (PSG) results, and need for supplemental oxygen were collected. Unpaired t test and Chi-square Test were used to compare results between groups.
Results: 31/46 had prenatal repair of MMC; average age at repair was 27 weeks post-conception (PCA). Average age at postnatal repair was 37 PCA. There was no difference in age at PSG. There was no difference in CIIM presence (p=0.61). 60% of patients with postnatal repair and 23% in the prenatal group underwent VPS placement (p=0.01).
There was no difference in PSG findings between the two groups: CAI (p=0.11), OAHI (p=0.64), average SpO2 baseline (p=0.91), average SpO2 nadir (p=0.17), average PETCO2 baseline (p=0.87), average PETCO2 maximum (p=0.54). There were no significant differences in the proportion of patients on supplemental O2 (p=0.25), CSA or OSA between groups.
Conclusions: Patients with SB who’ve undergone closure of defect have persistent central apneas, obstructive apneas, and significant hypoxemia. There were no differences in the frequency or severity of sleep-disordered breathing in those with prenatal repair versus postnatal repair.
Characterization of the complete mitochondrial genome of Ergasilus anchoratus and phylogeny of Copepoda
Authors: Hua Cong-jie , Huang Yan , Li Hui-quan , Feng Jin-mei , Qiao Jia-lu , Hu Song , Liu Wei , Shu Xi-ji 
Published: October 2023

Abstract

The mitochondrial (mt) genome can provide data for phylogenetic analyses and evolutionary biology. Herein, we sequenced and annotated the complete mt genome of Ergasilus anchoratus. This mt genome was 13852 bp long and comprised 13 protein-coding genes (PCGs), 22 tRNAs and 2 rRNAs. All PCGs used the standard ATN start codons and complete TAA/TAG termination codons. A majority of tRNA genes exhibited standard cloverleaf secondary structures, with the exception of one tRNA that lacked the TψC arm (trnC), and three tRNAs that lacked the DHU arm (trnR, trnS1 and trnS2). Phylogenetic analyses conducted using Bayesian inference (BI) and maximum likelihood (ML) methods both supported Ergasilidae as a monophyletic family forming a sister group to Lernaea cyprinacea and Paracyclopina nana. It also supported the monophyly of orders Calanoida, Cyclopoida, Harpacticoida, and Siphonostomatoida; and the monophyly of families Harpacticidae, Ergasilidae, Diaptomidae, and Calanidae. The gene orders of E. anchoratus and Sinergasilus undulatus were identical, which represents the first instance of two identical gene orders in copepods. More mt genomes are needed to better understand the phylogenetic relationships within Copepada in the future.
Designing and Validation an Experimental Protocol to Induce Airway Narrowing in Older Adults with and without Asthma
Authors: Chavoshian Shaghayegh , Cao Xiaoshu , Thommandram Anirudh , Stanbrook Matthew B , Tarlo Susan M , Fossat Yan , Yadollahi Azadeh 
Published: October 2023

Abstract
Background: Persons with asthma may experience excessive airway narrowing due to exercise or exposure to cold air, worsening their daily functionality. Exercise has several benefits for asthma control, but it may induce airway narrowing in some persons with asthma. When combined with cold temperatures, it introduces another layer of challenges. Therefore, managing this interaction is crucial to increase the quality of life in individuals with asthma. The purpose of this study was to develop a reliable experimental protocol to assess the effects of exercise and cold air on airway narrowing in adults with asthma, in a controlled and safe environment.
Methods: This study was a randomized cross-over study in adults with and without asthma. Participants underwent a protocol involving a 10-minute seated rest, followed by a 10-minute cycling on a stationary bike in different temperatures of 0, 10, or 20°C. The sequence of room temperatures was randomized and there was a 30-minute interval for recovery between each temperature transition. In each temperature, to measure lung function and respiratory symptoms, oscillometry and a questionnaire were used at 0 minute of sitting (baseline), after 10 minutes of sitting or before starting biking (pre-exercise), and after 10 minutes of biking (post-exercise). At each room temperature, the changes in airway mechanics and asthma symptoms among baseline, pre-exercise, and post-exercise were compared with one-way repeated measures ANOVA or Friedman Rank Test.
Results: A total of 23 persons with asthma (11 females, age: 56.3 ± 10.9 years, BMI: 27.4 ± 5.7 kg/m2) and 6 healthy subjects (3 females, age: 61.8 ± 9.1 years, BMI: 28.5 ± 3.1 kg/m2) were enrolled in the study. Cold temperature of 0°C induced airway narrowing in those with and without asthma after 10 and 20 minutes respectively. Exercise intervention had significant changes in airway narrowing in participants with asthma in the range of 10-20°C. Our results showed that in asthma, changes in subjective respiratory symptoms were due to both cold temperatures of 0 and 10°C and exercise in the 0-20°C range. Respiratory symptoms were not noticed among the healthy participants.
Conclusion: In conclusion, our findings suggest that exposure to cold temperatures of 0°C could serve as a reliable method in the experimental protocol for inducing airway narrowing in asthma. The impact of exercise on airway narrowing was more variable among participants. Understanding these triggers in the experimental protocol is essential for the successful management of asthma in future studies.
Establishment and Validation of Early Prediction Model for Hypertriglyceridemic Severe Acute Pancreatitis
Authors: Yi Shuanglian , Zeng Huiling , Lin Xunting , Deng Yifang , Lin Yufen , Xie Shanshan , Si Lijuan , Liu Yunpeng 
Published: October 2023

Abstract
Background
The prevalence of hypertriglyceridaemia-induced acute pancreatitis (HTG-AP) is increasing due to improvements in living standards and dietary changes. However, at present, there is no clinical multifactor scoring system specific to HTG-AP. This study aimed to screen the predictors of hypertriglyceridemia severe acute pancreatitis (HTG-SAP) and combined several indicators to establish and verify a visual model for the early prediction of HTG-SAP.
Methods
The clinical data of 266 patients with HTG-SAP were analysed. Patients were classified into severe (n = 42) and non-severe (n = 224) groups according to the Atlanta classification criteria. Several statistical analyses, including one-way analysis, least absolute shrinkage with selection operator (LASSO) regression model and binary logistic regression analysis were used to evaluate the data.
Result
The univariate analysis found that several factors showed no statistically significant differences, including number of episodes of pancreatitis, abdominal pain score and several blood diagnostic markers, such as lactate dehydrogenase (LDH), serum calcium (Ca2+), C-reactive protein (CRP) and the incidence of pleural effusion, between the two groups (P < 0.000). LASSO regression analysis identified six candidate predictors: CRP, LDH, Ca2+, procalcitonin (PCT), ascites and Balthazar computed tomography (CT) grade. Binary logistic regression multivariate analysis showed that CRP, LDH, Ca2+, and ascites were independent predictors of HTG-SAP. The area under the curve (AUC) was 0.886, 0.893, 0.872, and 0.850, respectively. The AUC of the newly established HTG-SAP model was 0.960 (95% confidence interval: 0.936–0.983), which was higher than that of the bedside index for severity in acute pancreatitis, modified CT severity index, Ranson score and Japanese severity score (JSS) CT grade (AUC: 0.794, 0.796, 0.894 and 0.764, respectively). The differences were statistically significant (P < 0.01), except for the JSS prognostic indicators (P = 0.130). The Hosmer–Lemeshow test showed that the predictive results of the model were highly consistent with the actual situation (P > 0.05). The decision curve analysis plot suggested that clinical intervention can benefit patients when the model predicts that they are at risk for developing HTG-SAP.
Conclusions
CRP, LDH, Ca2+ and ascites are independent predictors of HTG-SAP. The prediction model constructed based on these indicators has a high accuracy, sensitivity, consistency and practicability in predicting HTG-SAP.
Comparative Analysis of Short-term Efficacy between Robot- assisted Retrograde Drilling and Arthroscopic Microfracture for Osteochondral Lesions of the Talus
Authors: Xiaoqiang Chen , Jianquan Liu , Tianyu Wang , Zhe Zhao , Yongsheng Li , Yu Cheng Xiang , Wencui Li 
Published: October 2023

Abstract
Background
Osteochondral lesions of the talus (OCLT) are lesions involving the articular cartilage and subchondral bone of the talus, most of which are associated with chronic micro-injuries following ankle trauma.micro-fractures, cartilage or bone transplantation assisted by ankle arthroscopy and the use of surgical robots has emerged for the treatment of OCLT is the pursuit of doctors and patients. A novel surgical procedure is introduced from the perspective of surgical robots involved in the minimally-invasive treatment of early OCLT to reach the persuit.
Objective
To investigate the short-term clinical efficacy of robot-assisted retrograde drilling and arthroscopic microfracture for osteochondral lesions of the talus (OCLT).
Methods
A total of 6 OCLT patients who were treated with robot navigation-assisted retrograde drilling and 10 OCLT patients who were treated with arthroscopic microfracture between October 2020 and October 2021 were analyzed. There were 11 males and five females, with a mean age of 36 years. The patients were followed up for 6 to 12 months to compare the changes in the OCLT lesion area by magnetic resonance imaging (MRI), visual analogue scale/score (VAS) and American Orthopedic Foot and Ankle Society score (AOFAS) before and after surgery.
Results
All 16 patients were followed up for an average of 8 months, and no complications occurred.Only one patient suffered discomfort involving transient postoperative pain in the operative area, but did not experience long-term numbness or chronic pain. Postoperative MRI revealed that none of the patients had severe signs of osteonecrosis, osteolysis or cystic changes of the talus, with lesion areas smaller than those before surgery. The difference was statistically significant (P < 0.01). The patients in the experimental group showed a more significant improvement in the last 3 months than in the first 3 months of the follow-up period. At the last follow-up, the VAS score was 3 points in the experimental group and 2.2 points in the control group, and the AOFAS score was 88.6 points in the experimental group and 88 points in the control group, all of which were significantly higher than those before operation, and the differences were statistically significant, but there was no statistically significant difference between the groups.
Conclusion
Both robot navigation-assisted retrograde drilling and arthroscopic microfracture for bone marrow stimulation (BMS) to treat OCLT in all patients obtained a satisfied result. In addition, the the experimental group can significantly reduced the operative time and showed fewer complications. Consequently, robot navigation-assisted retrograde drilling for BMS was a safe and effective procedure for the treatment of OCLT.
Psychometric Properties of an Arabic Translation of the Short Entrapment Scale in a Non- Clinical Sample of Young Adults
Authors: Chabbouh Alfred , Charro Elie , Tekle Georges-Alain Al , Soufia Michel , Hallit Souheil 
Published: October 2023

Abstract
Background: Entrapment is defined as the feeling of wanting to leave an unbearable situation but believing that there are no options or ways to do so (i.e. inability to escape an unbearable situation). In clinical practice, it is crucial to regularly incorporate entrapment beliefs into the risk assessments and therapeutic interventions as entrapment beliefs are a significant risk factor for suicidal ideations. Therefore, in the current study, we aim to evaluate the psychometric properties of a translated Arabic version of the Entrapment Scale Short Form (E-SF).
Methods: 389 Lebanese citizens residing in the country at the time were enrolled in this cross-sectional study. The mean age of participants were 23.03 years (SD = 2.93), 69.4% being women. To examine the factor structure of the entrapment scale, we used an exploratory-to-confirmatory factor analysis (EFA-to-CFA) strategy.
Results: EFA and CFA results indicated that fit of the unidimensional model of Arabic Entrapment Scale (A-ES) was generally acceptable. Composite reliability of scores was adequate in the total sample (ω = .87). All indices suggested that configural, metric, and scalar invariance was supported across gender. Entrapment was positively and significantly correlated with suicidal ideation, alcohol use disorder, psychological distress and orthorexia nervosa, suggesting convergent and divergent validity.
Conclusion: The A-ES was found to be a valid and reliable tool to assess the degree of entrapment in Lebanese young adults. The A-ES will assist healthcare professionals in the region in the prevention of suicide as the tool is tailored to the specific sociocultural context, which would enhance entrapment detection.
Resistance to Erythropoiesis Stimulating Agents in Children Receiving Renal Replacement Theraphy
Authors: KAYA MEHTAP , CICEK NESLIHAN , GUVEN SERCIN , ALPAY HARIKA , GOKCE IBRAHIM 
Published: October 2023

Abstract
Background
The incidence of anemia increases with the stage of chronic kidney disease (CKD). Erythropoietin (EPO) deficiency is the common cause of anemia in CKD. Erythropoietin-stimulating agents (ESAs) are the mainstay of treatment. Sometimes, treatment is challenging due to erythropoietin resistance (ER), which can be assessed using the erythropoietin resistance index (ERI). In this study, our aim was to investigate the factors contributing to high ERI levels in children receiving renal replacement therapy (RRT).
Materials and Methods
Thirty-three children receiving hemodialysis (HD) or peritoneal dialysis (PD) for at least three months were included in this study. Demographic characteristics, laboratory parameters, blood pressure findings, and medication records were documented. The Erythropoietin Resistance Index was calculated by determining the ratio of the weekly EPO dosage adjusted for body weight to the hemoglobin (Hb) level.
Results
The mean ERI value was 15.7 IU/kg/w/g/dL. There was a significant association between serum phosphorus levels and ERI (p = 0.016, r = 0.41). Mean parathormone (PTH) level was also higher in the high ERI group (599 ± 351 vs 392 ± 320 pg/ml, p: 0.088). An association, close to the statistical significance, was present between ERI and hypertension (p = 0.06, r = 0.32).
Conclusion
Our study demonstrated a potential relationship between hyperphosphatemia, possibly secondary hyperparathyroidism, and ERI in children receiving RRT. Additionally, the association of hypertension and ERI should not be ignored.
Expression and Prognostic Value of MCM2 in type B thymomas
Authors: Du Xin , Cui Jian , Yu Xin-tao , Cao Ding-fang , Zhang Ying , Yu Lei , Li Shan-qing 
Published: October 2023

Abstract
Background: Thymic epithelial tumor (TET) is the most common type of mediastinal malignancies. Currently, there is no reliable biomarker for predicting the prognosis of patients with TET. The purpose of the study was to find out a target gene, which may serve as a potential prognostic biomarker for TET patients.
Methods: By mRNA microarray analysis of 30 specimens of fresh tumor tissue and peritumoral thymic tissue, the differentially expressed genes (DEGs) were screened out. The hub genes were identified from DEGs using protein-protein interaction (PPI). Survival analysis and enrichment analysis were performed to selected the target gene from hub genes. By establishing the validated cohort, we explored the association of the target gene expression with prognosis and clinicopathological characteristics.
Results: The 734 DEGs were differentially expressed between thymoma and peritumoral thymic tissue. The 9 hub genes were identified from DEGs, in which minichromosome maintenance proteins 2 (MCM2) was selected as the target gene. In the validated cohort, the expression of MCM2 in thymic epithelial cells was significantly associated with a prolonged progression-free survival (PFS) (HR=0.17; 95% confidence interval [CI]: 0.05-0.54; p=0.003), and it was also the independent risk factor of PFS in TETs (HR=0.26; 95% CI: 0.08-0.91; p=0.035). Further analyses showed that the expression of MCM2 was decreased from type B1 to B3 thymomas.
Conclusions: MCM2 expression was the independent risk factor for TETs. The expression of MCM2 was significantly associated with a prolonged PFS, and it was decreased from type B1 to B3 thymomas. Therefore, MCM2 may be a favorable prognostic marker in type B thymomas.