bluuebunny/crossref_metadata_2025_split huggingface dataset:
Efektivitas pelatihan menjahit dalam program mobile training unit pada BLK Tasikmalaya
Authors: Herwina Wiwin , Taqiyah Nur , Tillah Mardho , Simanungkalit Ayu Rasmini 
Published: January 2024

Dampak dari salah satu permasalahan yang cukup rumit yang dihadapi suatu bangsa adalah masalah pengangguran dan angkatan kerja yang semakin membengkak.Â mengakibat tidak tertampungnya angkatan kerja pada instansi pemerintah maupun swasta. UntukÂ mengatasi hal tersebut pemerintah telah menetapkan kebijakan untuk menekan angka pengangguran tersebut dengan memberikan pelatihan keterampilan bagi usia angkatan kerja yang produktif. Kebijakan pemerintah memberikan pelatihan keterampilan bagi usia angkatan kerja produktif ini dilaksanakan di balai Latihan kerja kabupaten tasikmalaya. menurut Abdurahmat (2003:92) dalam (Purwaningsih et al., 2002, p. 16) â€œefektivitas adalah pemanfaatan sumber daya, sarana dan prasarana dalam jumlah tertentu yang secara sadar ditetapkan sebelumnya untuk menghasilkan sejumlah pekerjaan tepat pada waktunyaâ€. Pelatihan keterampilan ini meliputi menjahit, tata boga, dan las dalam program Mobile Training Unit (MTU) di gelar di rumah- rumah warga setempat.Identifikasi kebutuhan pelatihan, yang bertujuan untuk melihat dan menentukan peatihan apa yang akan diadakan berdasarkan kebutuhan peserta pelatihan, merupakan salah satu langkahnya. Membuat program diklat,seperti Menyusun kurikulum dan menyiapkan alat bantu ajar yang di perlukan. Melaksanakan program diklat dengan menyeleksi calon peserta pelatihan dan melaksanakan diklat evaluasi dalam bentuk evaluasi kejuruan dan program. Kesimpulannya dengan model pelatihan berbasis kompetensi yang dilakukan Balai Latihan Kerja Tasikmalaya bisa menjadikan lulusan peserta pelatihan sebagai tenaga kerja yang profesional, sehingga bisa membantu mengurangi angka pengangguran di Tasikmalaya. Permasalahan dalam penelitian ini dirumuskan sebagai berikut : Bagaimanakah efektivitas pelatihan menjahit dalam program mobile training unit yang di laksanakan di BLK kabupaten tasikmalaya? Berdasarkan hasil penelitian dengan analisis data kualitatif maka disimpulkan bahwa pelatihan keterampilan dari beberapa jurusan seperti menjahit, tataboga, las. Yang dilaksanakan di BLK kabupaten tasikmalaya,telah mampu menumbuhkan kewirausahaan secara efektif pada angkatan kerja produktif pada tahun 2022.Kata kunci: Efektivitas, pelatihan, menjahit,mobile training unit,instruktur
TLR7/8: a paradigm for the manipulation of immunologic reactions for immunotherapy
Authors: Li Shen , Song Jumin , Zhang Ke , Zhang Changle , Deng Guangwei 
Published: January 2024

The innate immune system recognizes conserved features of viral and
microbial pathogens via pattern recognition receptors (PRRs). Toll-like
receptors (TLRs) are one type of PRRs used by the innate immune system
to mediate the secretion of pro-inflammatory cytokines and promote
innate and adaptive immune responses. TLR family members TLR7 and TLR8
(refer as TLR7/8 subsequent) are endosomal transmembrane receptors that
recognize purine-rich single-stranded RNA and bacterial DNA and thereby
elicit an immunologic reaction to pathogens. TLR7/8 have been
demonstrated to mediate pro-inflammatory cytokine secretion by
activating immune cells. Accumulating evidence indicate that TLR7/8 are
closely related to numerous immune-mediated disorders, specifically
cancers, autoimmune diseases, and viral diseases. The TLR7/8 agonists
and antagonist used as drugs or adjuvants have been well identified in
preclinical studies and clinical trials as promising immunostimulators
for the immunotherapy of these immune-mediated disorders. These
achievements are a good reason for humans to open new doors for
exploring immunotherapy of immune-mediated disorders. Nevertheless, many
needs remain unmet, and their therapeutic effects are poor, and always
cause strong immune-related toxicities. In this mini review, we present
an overview of the TLR family members, particularly TLR7/8, and address
the underlying molecular mechanisms and clinical implications of TLR7/8
in immune-mediated disorders.
Hemoadsorption (CytoSorb®) in management of Cytokine Storm - Implication in COVID-19 pandemic.
Authors: Maheshwarappa Harish Mallapura , Joshi Shreedhar , Premkumar Robert , Mishra Shivangi , Prasad Shiva , Kanchi Muralidhar 
Published: January 2024

Background: Sepsis-related deaths contribute up to 20% of all global
deaths, with the highest-burden from sub-Saharan Africa and Southeast
Asia. Cytokines are the mediators of organ dysfunction in systemic
inflammatory response syndrome (SIRS) across varied aetiologies,
including sepsis. The imbalance of pro and anti-inflammatory cytokines
continues to be the crux of the pathophysiology of organ dysfunction in
septic shock. Therapies to treat cytokines either by antagonizing them
or filtering them out of the body are evolving. Hemoadsorption is a
process of filtering out cytokines and other metabolites involved in
SIRS by surface adsorption. Methods: We searched for terms –
Hemoadsorption; CytoSorb; in PubMed. We enrolled manuscripts with
patients at Indian Centres for review. We extend our review of cytokine
storm in COVID-19 and the utility of CytoSorb as an adjuvant in the
management of septic shock in COVID-19. Results: Severe acute
respiratory syndrome coronavirus -2 (SARS-CoV-2) infection causing
COVID-19 (Corona Virus disease - 2019) pandemic has affirmed cytokine
storm as the principle pathology causing morbidity and mortality.
Management strategies are mostly supportive since specific anti-viral
therapy is still in the incipient stage. Cytokine adsorption is being
used across most western countries in COVID-19 septic shock.
Conclusion: COVID-19 with cytokine storm as its main pathology is a
suitable substrate for the use of CytoSorb. COVID-19 patients with
elevated cytokine levels can be offered CytoSorb® hemoadsorption along
with other supportive therapies.
Fructose 1,6-bisphosphatase and gluconeogenesis control in an anoxia-tolerant turtle, Trachemys scripta elegans
Authors: Gupta Aakriti , Varma Anchal , Storey Kenneth 
Published: January 2024

The red eared slider ( Trachemys scripta elegans) undergoes
numerous changes to its physiological and metabolic processes to survive
without oxygen. During anoxic conditions, its metabolic rate drops
drastically to minimise energy requirements. The alterations in central
metabolic pathways are often accomplished by the regulation of key
enzymes. The regulation of one such enzyme, fructose-1,6-bisphosphatase
(FBPase; EC 3.1.3.11), was characterized in the present study during
anoxia in liver. FBPase is a crucial enzyme of gluconeogenesis. FBPase
was purified from liver tissue in both control and anoxic conditions and
subsequently assayed to determine the kinetic parameters of the enzyme.
Studies revealed the relative degree of posttranslational modifications
in FBPase from control and anoxic turtles. Further, this study
demonstrated a significant decrease in the maximal activity in anoxic
FBPase and decreased sensitivity to its substrate
fructose-1,6-bisphosphate (FBP) when compared to the control.
Immunoblotting demonstrated increased threonine phosphorylation
(~1.4 fold) in the anoxic FBPase. Taken together these
results suggest that phosphorylation of liver FBPase is an important
step in suppressing FBPase activity ultimately leading to inhibition of
gluconeogenesis in the liver of the red eared slider during anaerobic
conditions.
Genetic predisposition to allergic rhinitis in relation to 11 psychiatric disorders
Authors: Zhang Xiaowen , Liao Wenjing , Song Lijuan , Xie Junyang , Chen Gui , Liang Tianhao , Li Ang , Zhang Chunyi , Xu Meiqian , Li Hao , Xie Jianlei , Yang Pingchang , Han Deming , Zhong Nanshan 
Published: January 2024

Background: Growing evidence from observational studies
suggests a link between
Allergic [rhinitis](https://www.sciencedirect.com/topics/neuroscience/rhinitis) (AR)
and psychiatric disorders; whether these associations represent causal
relationships remains uncertain. Methods: We performed
bi-directional two-sample mendelian randomization (MR) using summary
statistics from European genome-wide association studies to examine
evidence of causality, specificity and direction of association of AR
with 11 different psychiatric disorders or relevant traits. MR was
conducted using the inverse-variance weighted method (IVW), MR-Egger and
weighted median methods. Sensitivity analyses included the MR-Egger
regression and MR pleiotropy residual sum and outlier test.
Results: AR from 2 different GWAS data was positively
associated with bipolar disorder (OR=1.649, 95% CI: 1.077-2.526;
P=0.021; OR=1.599; 95%CI 1.058-2.417; P=0.026). AR was also associated
with major depressive disorder (OR=1.539; 95%CI 1.007-2.353; P=0.047).
There were no significant association between AR and other 9 psychiatric
disorders. Bidirectional analyses showed that bipolar disorder is
negatively associated with AR (OR=0.964; 95%CI: 0.936-0.993; P=0.015).
There was no evidence for potential causal schizophrenia and effects of
attention deficit/hyperactivity disorder on risk of AR by MR method,
but, MR pleiotropy residual outlier test suggested that attention
deficit/hyperactivity disorder is negatively associated with AR after
outlier correction (OR=0.976, 95%CI: 0.958-0.995, P=0.012).
Conclusions: This MR study indicated that AR was a causal risk
factor for bipolar disorder and major depressive disorder, but not for
other psychiatric disorders. Bipolar disorder and attention
deficit/hyperactivity disorder may be a protective factor for AR.
Further studies could be carried out to leverage these new found insight
into better clinical and experimental research in AR and psychiatric
disorders.
The potential mechanism of transient receptor potential vanilloid type 1 combined with ATP-sensitive potassium channel in severe preeclampsia
Authors: Zhou Xianyi , Li Wei , Lin Hairui , Tan Yingjun , Fu Xiaodong 
Published: January 2024

Objective To investigate the potential mechanism of transient receptor
potential vanilloid type 1 (TRPV1) and ATP-sensitive potassium channel
(KATP) in severe preeclampsia. Design Basic research. Setting The
pathogenesis of severe preeclampsia. Samples Human placental arterioles
and HUVECs. Methods (1) Tissue level: The samples were divided into the
normotensive pregnancy (NP) group and severe preeclampsia (SP) group.
Hematoxylin-eosin staining, quantitative PCR, Western blotting and
immunohistochemistry were performed. (2) Cellular level: The samples
were divided into the control group, TRPV1 agonist group (capsaicin),
and TRPV1 inhibitor group (capsazepine), quantitative PCR and Western
blotting were performed. Main Outcome Measures The relative expression
of TRPV1, KATP subtype Kir6.1/SUR2B, nitric oxide synthase (eNOS) in
placental arterioles ; the relative expression of TRPV1, Kir6.1/SUR2B,
and eNOS in the cell groups. Results (1) The endothelial cell layer in
the SP group was obviously damaged. The relative gene and protein
expression of TRPV1, Kir6.1, SUR2B and eNOS was significantly lower than
that in the NP group (P<0.01). (2) The relative gene and
protein expression of TRPV1, Kir6.1, SUR2B and eNOS in the control group
were significantly lower than those in the capsaicin group
(P<0.01) and were significantly higher than those in the
capsazepine group (P<0.01). Conclusion TRPV1 plus the
downregulation of KATP downregulates the expression of eNOS, reducing
vasodilation, which may be critical in the pathogenesis of severe
preeclampsia. Funding Luzhou Science and Technology Bureau (
2020-SYF-27). Key words: Transient receptor potential vanilloid type 1;
ATP-sensitive potassium channel; Endothelial nitric oxide synthase;
Nitric oxide; Severe preeclampsia
High accuracy extrapolation cascadic Newton multigrid computation for two-dimensional nonlinear Poisson equations
Authors: Li Ming , LI Chenglin 
Published: January 2024

An extrapolation cascadic Newton multigrid (ECNMG) method is proposed
for high accuracy numerical solutions of two-dimensional nonlinear
Poisson equations, by incorporating the fourth-order compact difference
schemes, the extrapolation techniques and the existing Newton multigrid
method. A series of grid level dependent computational tolerances are
discussed to distribute computational cost on different grids, and an
extrapolation interpolation strategy and a bi-quartic polynomial
interpolation are used for two fourth-order approximations from current
and previous grids to provide an extremely accurate initial guess on the
next finer grid, which can greatly reduce the iterations of the Newton
multigrid computation for computing an approximation with
discretization-level accuracy. Additionally, a completed Richardson
extrapolation technique is adopted for the fourth-order computed
solution to generate a sixth-order extrapolated solution cheaply.
Numerical results of two-dimensional nonlinear Poisson-Boltzmann
equations with five different fourth-order compact difference schemes
are conducted to demonstrate the new ECNMG algorithm achieve sixth-order
accuracy and keep less cost simultaneously, more efficient than the
existing Newton-MG method.
Right ventricular perforation after percutaneous vertebroplasty:A case report
Authors: Teng Rong , Qin Haocheng , Zhao Jing , Yu Ming , Zhang jie , Li Yong 
Published: January 2024

Percutaneous vertebroplasty (PVP) is an increasingly important procedure
in orthopaedics. Bone cement leakage after PVP is a widely described
complication, which is very rare and serious when it causes cardiac
involvement. A 73-year-old man who underwent PVP for a lumbar fracture
developed chest tightness and shortness of breath 8 months after
surgery, and had a sudden syncope one year after surgery. Imaging
examination suggested a strip of foreign body in the right atrium and
the right ventricle. The patient underwent emergency open heart surgery.
The surgery was successful and the 9cm bone cement foreign body was
completely removed.
EFEKTIVITAS LAYANAN SAMSAT KELILING DALAM UPAYA MENINGKATKAN PENDAPATAN PAJAK KENDARAAN BERMOTOR
Authors: Pebriani Adela , Sulaeman Sulaeman 
Published: January 2024

Penelitian ini bertujuan untuk mengetahui efektivitas layanan SAMSAT keliling dalam upaya meningkatkan pendapatan pajak kendaraan bermotor di SAMSAT Wilayah Kabupaten Sukabumi 1 Cibadak. Seperti yang diketahui sebelumnya bahwa proses pembayaran pajak memerlukan waktu yang sangat lama. Untuk mengantisipasi agar mengurangi masalah tersebut maka dibentuklah unit pembantu berupa SAMSAT keliling yang terdiri seperti bus yang beroperasi di beberapa titik untuk melakukan pembayaran pajak. Sehingga penelitian ini dibuat agar dapat meninjau dan melihat keefektivan pada SAMSAT keliling dalam meningkatkan pendapatan pajak kendaraan bermotor,
Hasil dari penelitian ini menunjukkan layanan SAMSAT Keliling telah sesuai dengan Keputusan Menteri Pendayagunaan Aparatur Negara No. 63/KEP/M-PAN/7/2003 tentang Pedoman Umum Penyelenggaraan Pelayanan Publik serta pelayanannya cukup berkualitas,Dengan adanya SAMSAT keliling ini masyarakat wajib pajak dapat dengan mudah membayar pajak tanpa harus menunggu waktu yang lama tidak harus melewati beberapa loket .Pelayanan menggunakan SAMSAT keliling ini juga dapat mengurangi antrian masyarakat wajib pajak yang datang langsung ke SAMSAT induk, Untuk penggunaan SAMSAT keliling ini sudah efektif . Dengan perolehan rata- rata efektivitas sebesar 97,2% maka tingkat efektifitas antara target dan realisasi penerimaan dengan kata lain sudah efektif.
PSYCHOLOGICAL FACTORS DETERMINING THE EFFECTIVENESS OF MILITARY SERVICE
Authors: Gevorgyan Hakob 
Published: January 2024

ABSTRACT
The article discusses the effectiveness of the junior officer's service activity according to the described characteristics. It is well known that to achieve military success requires not only modern armaments and military equipment, but also mentally and physically trained personnel with the necessary professional knowledge, skills, certain characteristics at all levels of management. Therefore, from the point of view of maintaining combat readiness and continuously raising its level in the Armed Forces, it may be important and valuable to identify the psychological mechanisms for assessing the Effectiveness of Military Service (EMS), in the Armed Forces which will contribute to effective human resource management in the Armed Forces.
Una historia de la fotografía desde las prácticas amateurs.
Authors: F. Rius Núria 
Published: January 2024

Este artículo analiza las posibilidades epistemológicas y metodológicas del estudio de la fotografía amateur producida entre el último cuarto del siglo XIX y la década de 1960, período en que decaen los usos históricos de la fotografía (Bajac, 2010, p. 54). Entendemos por fotografía amateur aquella que se realiza fuera de las lógicas productivas del sector profesional y artístico, sin que ello conlleve la imposibilidad de que en algún momento sea monetizada o circule por los espacios institucionales del arte y de la fotografía artística.
El estudio parte de la hipótesis que el amateurismo fue uno de los pilares sobre los cuales se desarrolló el invento de la fotografía, siendo, por consiguiente, uno de los factores preeminentes en la historia del medio. Resultó nuclear en el desarrollo de la fotografía al participar de un proceso histórico de universalización de los saberes en arte propios de la modernidad que la hicieron accesible a diferentes grupos sociales. Su estudio contribuye a lecturas historiográficas más plurales y complejas en cuanto a usuarios, géneros, circuitos y utilidades. Lo hace al contemplar la práctica fotográfica con una perspectiva interseccional, que amplía y tensiona el modelo de la “historia del arte de la fotografía” (Phillips, 1982, p. 35).
Aortic patient-prosthesis mismatch - does it matter? A review for cardiologists and cardiac surgeons
Authors: Visan Alexandru C , Zlibut Alexandru , Ionescu Adrian , Stoica Serban C 
Published: January 2024

Abstract
Patient-prosthesis mismatch (PPM) is the situation in which the area of an artificial valve is smaller than that of a healthy native valve it replaces. By this definition, all artificial valves demonstrate PPM, but large observational studies and several meta-analyses suggest that it is present in 30-50% of patients after surgical aortic valve replacement (SAVR). PPM has an impact on outcomes only when the indexed aortic valve area (AVAi) is ≤0.85cm2/m2 (moderate PPM) or 0.65cm2/m2 (severe PPM), particularly in patients with reduced LVEF. In transcatheter aortic valve replacement, the prevalence of PPM may be as low as 0.1%, and its impact on hard outcomes is not clear. We present a review of the relevant literature together with a framework for the differential diagnosis of increased pressure gradient and reduced area in prosthetic aortic valves and different strategies to reduce the risk of PPM with SAVR.
Neuroscience of Hypnosis: A Neurophysiological View of Hypnotherapy
Authors: Barbosa Fernando Campos , Tadine Rodrigo Martins , Rezende Janaina Drawanz Pereira , Lopes Gabriel César Dias , Attie André , Machado Sandro , Barbosa Estélio Silva 
Published: January 2024

Objective: This narrative literature review is intended to briefly clarify the history and concepts of hypnosis, history, scientific advancement in the field and therapeutic applications. The theme will have greater contextualization regarding the neurophysiology of hypnosis.

Methods: In this bibliographic review (databases, websites and specialized journals) studies were selected seeking as keywords "Hypnosis", "Neurobiology", "Hypnotic Response", "Historical", "Research", to approach these concepts in the clinical area and research in the health area, in order to seek greater grounding on the concepts and neurobiological mechanisms involved in hypnotherapy. The databases evaluated were MEDLINE, GOOGLE ACADEMIC, PUBMED, SCIENCE DIRECT, SciELO and LILACS.

Results: In the selected studies on the theme, the concepts on hypnotherapy and history are addressed. Hypnosis, recognized as a psychobiological process, modifies brain activity, affecting areas such as sensory cortexes, the dorsal anterior cingulate gyrus, and the prefrontal cortex. This neurocognitive alteration influences perception, making hypnosis an effective tool in the modulation of various clinical conditions in a way that complements conventional therapy.

Conclusion: The neurophysiology of hypnosis is a field in constant evolution. Although the exact understanding of the neurophysiological processes underlying hypnosis is not yet fully understood, advances in neuroscience reveal insights into the hypnotic response. The progress in new neuroimaging technologies and methodologies may provide clearer answers about the mechanisms involved in hypnotherapy, as well as proving the effectiveness of its application.
Fabulation as Design
Authors: Konrath Germana , Reyes Paulo Edison Belo 
Published: January 2024

Objective: In urban planning, the idea of designing not only space but also time is fundamental and transformative, given its implications for the way we think and produce cities. In this sense, the article seeks to explore different methods of urban design based on a temporal matrix.

Method and theoretical framework: We bring forth two poetic actions developed by the contemporary artist Francis Alÿs, where the concepts of fable and project are present. Alÿs's poetics (empiricism) are discussed here and intersected with theoretical concepts from a literature review, highlighting the notion of the right to the city from Henri Lefebvre, the understanding of utopia from Ernst Bloch, and the concept of politics from Jacques Rancière.

Results and conclusion: Alÿs's works borrow from literature their quality of adaptation. Oral accounts can both intensify and reiterate a story and allow each part to accommodate itself in new contexts. Thus, fables adapt to each situation where they are told, like nomads. Empiricism opens up possibilities that span literature, visual arts, philosophy, and urban planning.

Implications of the research: The text enhances a dialogue between poetics, aesthetics, ethics, and politics. It is not a methodology for improving or presenting projects; rather, it is a possible path to initiate new thoughts and design practices for the contemporary city.

Originality: The understanding of fabulation as urban design within a broader perspective of design practice and its impact on the built environment.
Long-term Family Support
Authors: Ragadics Tamás 
Published: January 2024

East Central European rural areas face diverse challenges of social transformation: rural exodus, ageing, poverty and segregation take effect on countryside as parallel phenomena. Problems are connected with the transformation of agriculture, with the lack of services and the negative trends of migration. In spite of several supportive governmental and EU-projects, lower level of rural life standard and deepening social gaps are existing and deepening problems in post- socialist countries.
”Emerging Settlements” Programme is a new, long-term social programme of Hungarian government targeting the support of families and help children „from conception to labour market”. This unique project is implemented by church-based organizations in the most underdeveloped 300 Hungarian settlements. This paper aims to describe the main elements of proceeding programme on the base of project documentation and interviews with co-working social experts. Based on local experiments we highlight some critical viewpoints for developing supporting interventions, displaying the meaning of social participation of church organizations.