bluuebunny/crossref_metadata_2025_split huggingface dataset:
Assessing injury risk in male and female Royal Navy recruits: does the Functional Movement Screen provide understanding to inform effective injury mitigation?
Authors: Gibbs J. , Power C N T , Böhning D , Warner M , Downie S , Allsopp A , Stokes M , Fallowfield J L 
Published: November 2023

IntroductionMusculoskeletal injuries (MSKIs) are common during military and other occupational physical training programmes, and employers have a duty of care to mitigate this injury risk. MSKIs account for a high number of working days lost during initial military training, contribute to training attrition and impact training costs. Poorer movement quality may be associated with increased MSKI risk.MethodsThe present study evaluated the relationship between the Functional Movement Screen (FMS) Score, as a measure of movement quality, and injury risk in Royal Navy (RN) recruits. A cohort of 957 recruits was assessed using the FMS prior to the 10-week phase I training programme. Injury occurrence, time, type and severity were recorded prospectively during the training period.ResultsTotal FMS Score was associated with injury risk (p≤0.001), where recruits scoring ≥13 were 2.6 times more likely to sustain an injury during training. However, FMS Score accounted for only 10% of the variance in injury risk (R2=0.1). Sex was the only additional variable to significantly affect the regression model. Mean FMS Scores for men (14.6±2.3) and women (14.4±2.4) were similar, but injury occurrence in women was 1.7 times greater than in men. Examining the influence of individual FMS movement tests on injury prediction did not improve the model, where those movements that significantly contributed to injury prediction only accounted for a small amount of the variance (R2=0.01).ConclusionThere was a weak relationship between FMS and injury risk in RN recruits. Evidence is provided that FMS score alone would not be appropriate to use as an injury prediction tool in military recruits.
Automated Quality Evaluation of Large-Scale Benchmark Datasets for Vision-Language Tasks
Authors: Zhao Ruibin , Xie Zhiwei , Zhuang Yipeng , L. H. Yu Philip 
Published: November 2023

Large-scale benchmark datasets are crucial in advancing research within the computer science communities. They enable the development of more sophisticated AI models and serve as “golden” benchmarks for evaluating their performance. Thus, ensuring the quality of these datasets is of utmost importance for academic research and the progress of AI systems. For the emerging vision-language tasks, some datasets have been created and frequently used, such as Flickr30k, COCO, and NoCaps, which typically contain a large number of images paired with their ground-truth textual descriptions. In this paper, an automatic method is proposed to assess the quality of large-scale benchmark datasets designed for vision-language tasks. In particular, a new cross-modal matching model is developed, which is capable of automatically scoring the textual descriptions of visual images. Subsequently, this model is employed to evaluate the quality of vision-language datasets by automatically assigning a score to each ‘ground-truth’ description for every image picture. With a good agreement between manual and automated scoring results on the datasets, our findings reveal significant disparities in the quality of the ground-truth descriptions included in the benchmark datasets. Even more surprising, it is evident that a small portion of the descriptions are unsuitable for serving as reliable ground-truth references. These discoveries emphasize the need for careful utilization of these publicly accessible benchmark databases.
Amoeba: Circumventing ML-supported Network Censorship via Adversarial Reinforcement Learning
Authors: Liu Haoyu , Diallo Alec F. , Patras Paul 
Published: November 2023

Embedding covert streams into a cover channel is a common approach to circumventing Internet censorship, due to censors' inability to examine encrypted information in otherwise permitted protocols (Skype, HTTPS, etc.). However, recent advances in machine learning (ML) enable detecting a range of anti-censorship systems by learning distinct statistical patterns hidden in traffic flows. Therefore, designing obfuscation solutions able to generate traffic that is statistically similar to innocuous network activity, in order to deceive ML-based classifiers at line speed, is difficult.
In this paper, we formulate a practical adversarial attack strategy against flow classifiers as a method for circumventing censorship. Specifically, we cast the problem of finding adversarial flows that will be misclassified as a sequence generation task, which we solve with Amoeba, a novel reinforcement learning algorithm that we design. Amoeba works by interacting with censoring classifiers without any knowledge of their model structure, but by crafting packets and observing the classifiers' decisions, in order to guide the sequence generation process. Our experiments using data collected from two popular anti-censorship systems demonstrate that Amoeba can effectively shape adversarial flows that have on average 94% attack success rate against a range of ML algorithms. In addition, we show that these adversarial flows are robust in different network environments and possess transferability across various ML models, meaning that once trained against one, our agent can subvert other censoring classifiers without retraining.
Revocation Speedrun: How the WebPKI Copes with Fraudulent Certificates
Authors: Friess Jens , Schulmann Haya , Waidner Michael 
Published: November 2023

The TLS ecosystem depends on certificates to bootstrap secure connections. Certificate Authorities (CAs) are trusted to issue these correctly. However, as a result of security breaches or attacks, certificates may be issued fraudulently and need to be revoked prematurely.
Revocation, as a reactive measure, is fundamentally damage control and, as such, time is critical. Therefore, measuring reaction delay is the first step to identifying how well the revocation system functions.
In this paper we attempt to characterize the current performance of the WebPKI in dealing with fraudulent certificates. We present measurements of each step in the revocation process: the detection of certificate issuance through Certificate Transparency (CT) monitoring, the administrative revocation process at popular CAs, and the revocation checking behavior of end-user clients, both in a controlled virtualized environment and in the wild. We perform two live measurements, in 2022 and 2023, respectively, to provide a longitudinal comparison.
We find that detection and revocation of fraudulent certificates is quick and efficient when leveraging CT and can be completed within 6.5 hours on average. Furthermore, CT is being increasingly enforced by some browsers. However, ∼83% of the clients we observed, across popular browsers, brands and OSes, completely disregard a certificate's status, whileall of the studied browsers still display soft-fail behavior, making them vulnerable to attackers capable of interfering with the network. Of the clients that do check revocation, we find that 35% can be made to accept a revoked certificate through the use of OCSP Stapling. We expect this number to grow with client-side adoption of OCSP Stapling [RFC6961]. Current OCSP expiration times allow a revoked certificate to remain fully valid for up to 7 days for the majority of CAs, exposing clients to attacks.
Polygenic Risk Score Modifies Prostate Cancer Risk of Pathogenic Variants in Men of African Ancestry
Authors: Hughley Raymond W. , Matejcic Marco , Song Ziwei , Sheng Xin , Wan Peggy , Xia Lucy , Hart Steven N. , Hu Chunling , Yadav Siddhartha , Lubmawa Alexander , Kiddu Vicky , Asiimwe Frank , Amanya Colline , Mutema George , Job Kuteesa , Ssebakumba Mbaaga K. , Ingles Sue A. , Hamilton Ann S. , Couch Fergus J. , Watya Stephen , Conti David V. , Darst Burcu F. , Haiman Christopher A. 
Published: November 2023

Abstract

Prostate cancer risk is influenced by rare and common germline variants. We examined the aggregate association of rare germline pathogenic/likely pathogenic/deleterious (P/LP/D) variants in ATM, BRCA2, PALB2, and NBN with a polygenic risk score (PRS) on prostate cancer risk among 1,796 prostate cancer cases (222 metastatic) and 1,424 controls of African ancestry. Relative to P/LP/D non-carriers at average genetic risk (33%–66% of PRS), men with low (0%–33%) and high (66%–100%) PRS had Odds Ratios (ORs) for overall prostate cancer of 2.08 [95% confidence interval (CI) = 0.58–7.49] and 18.06 (95% CI = 4.24–76.84) among P/LP/D carriers and 0.57 (95% CI = 0.46–0.71) and 3.02 (95% CI = 2.53–3.60) among non-carriers, respectively. The OR for metastatic prostate cancer was 2.73 (95% CI = 0.24–30.54) and 28.99 (95% CI = 4.39–191.43) among P/LP/D carriers and 0.54 (95% CI = 0.31–0.95) and 3.22 (95% CI = 2.20–4.73) among non-carriers, for men with low and high PRS, respectively. Lifetime absolute risks of overall prostate cancer increased with PRS (low to high) from 9.8% to 51.5% in P/LP/D carriers and 5.5% to 23.9% in non-carriers. Lifetime absolute risks of metastatic prostate cancer increased with PRS from 1.9% to 18.1% in P/LP/D carriers and 0.3% to 2.2% in non-carriers These findings suggest that assessment of prostate cancer risk for rare variant carriers should include PRS status.

Significance:
These findings highlight the importance of considering rare and common variants to comprehensively assess prostate cancer risk in men of African ancestry.
Prevalence of and Factors Associated With High Blood Pressure at 15 Years of Age: A Birth Cohort Study
Authors: Petracco Andrea Mabilde , Mattiello Rita , Bortolotto Caroline Cardozo , Ferreira Rodrigo Wiltgen , Matijasevich Alicia , de Barros Fernando Celso Lopes Fernandes , Friedrich Frederico Orlando , Tovo‐Rodrigues Luciana , de Barros Aluísio Jardim Dornellas , Santos Iná S. 
Published: November 2023

Background
Arterial hypertension is the greatest cause of morbidity and mortality worldwide. Our aim was to investigate the prevalence of and factors associated with high blood pressure (HBP) among adolescents.

Methods and Results
The Pelotas 2004 Birth Cohort included 4231 newborns from hospital births in Pelotas, Brazil. A digital automatic OMRON sphygmomanometer (model HEM 742) was used to measure blood pressure on 3 occasions (at 6, 11, and 15 years of age). Those with blood pressure ≥95th percentile for age, height, and sex on each of the 3 occasions were considered as presenting HBP. Independent variables included family (income and history of arterial hypertension), maternal (schooling, age, pregestational body mass index, and smoking during pregnancy), and adolescent characteristics at birth (sex, skin color, gestational age, intrauterine growth, and systolic and diastolic genetic factors), and at 15 years (sleep, physical activity, sodium intake, screen time, work, body mass index, fat mass index, fat‐free mass index, growth pattern, and puberty status). The prevalence of HBP (95% CI) was calculated. Crude and adjusted odds ratios (ORs) stratified by sex were obtained by logistic regression. A total of 1417 adolescents with complete information on blood pressure on the 3 occasions were analyzed. The prevalence of HBP was 3.2% (95% CI, 1.9%–4.5%) in female adolescents and 4.3% (95% CI, 2.8%–5.8%) in male adolescents. Female adolescents with a family history of arterial hypertension had a 3 times higher chance of HBP than their counterparts (OR, 3.1 [95% CI, 1.26–7.54]). In male adolescents, excessive maternal pregestational weight was associated with a 2.3‐fold increase in the chance of HBP. In both sexes, excessive adolescent weight was associated with HBP (ORs, 3.5 and 5.0, for female and male adolescents, respectively). A higher fat mass index and fat‐free mass index in female (ORs, 1.4 and 1.2, respectively) and male adolescents (ORs, 2.5 and 3.0, respectively) increased the chance of HBP. Among male adolescents, the chance of HBP was higher among those with rapid weight gain between 48 months and 6 years and between 6 and 11 years and rapid height gain between 6 and 11 years.

Conclusions
Higher fat mass in both sexes and rapid weight gain in male adolescents are risk factors for HBP in adolescents aged 15 years, potentially amenable to prevention.
Nonhypertensive White Matter Hyperintensities in Stroke: Risk Factors, Neuroimaging Characteristics, and Prognosis
Authors: Lim Jae‐Sung , Lee Keon‐Joo , Kim Beom Joon , Ryu Wi‐Sun , Chung Jinyong , Gwak Dong‐Seok , Lee Ji Sung , Kim Seong‐Eun , Ko Eunvin , Lee Juneyoung , Han Moon‐Ku , Smith Eric E. , Kim Dong‐Eog , Bae Hee‐Joon 
Published: November 2023

Background
This study explored the risk factors, neuroimaging features, and prognostic implications of nonhypertensive white matter hyperintensity (WMH) in patients with acute ischemic stroke and transient ischemic attack.

Methods and Results

We included 2283 patients with hypertension and 1003 without from a pool of 10 602. Associations of moderate‐to‐severe WMH with known risk factors, functional outcome, and a composite of recurrent stroke, myocardial infarction, and all‐cause mortality were evaluated. A subset of 351 patients without hypertension and age‐ and sex‐matched pairs with hypertension and moderate‐to‐severe WMH was created for a detailed topographic examination of WMH, lacunes, and microbleeds. Approximately 35% of patients without hypertension and 65% of patients with hypertensive stroke exhibited moderate‐to‐severe WMH. WMH was associated with age, female sex, and previous stroke, irrespective of hypertension. In patients without hypertension, WMH was associated with initial systolic blood pressure and was more common in the anterior temporal region. In patients with hypertension, WMH was associated with small vessel occlusion as a stroke mechanism and was more frequent in the periventricular region near the posterior horn of the lateral ventricle. The higher prevalence of occipital microbleeds in patients without hypertension and deep subcortical lacunes in patients with hypertension were also observed. Associations of moderate‐to‐severe WMH with 3‐month functional outcome and 1‐year cumulative incidence of the composite outcome were significant (both
P
<0.01), although the latter lost significance after adjustments. The associations between WMH and outcomes were consistent across hypertensive status.

Conclusions
One‐third of patients without hypertension with stroke have moderate‐to‐severe WMH. The pathogenesis of WMH may differ between patients without and with hypertension, but its impact on outcome appears similar.
Statin Therapy Is Associated With a Lower Risk of Heart Failure in Patients With Atrial Fibrillation: A Population‐Based Study
Authors: Huang Jia‐Yi , Chan Yap‐Hang , Tse Yi‐Kei , Yu Si‐Yeung , Li Hang‐Long , Chen Cong , Zhao Chun‐Ting , Liu Ming‐Ya , Wu Mei‐Zhen , Ren Qing‐Wen , Leung Ka‐Lam , Hung Denise , Li Xin‐Li , Tse Hung‐Fat , Lip Gregory Y. H. , Yiu Kai‐Hang 
Published: November 2023

Background
Whether statin use can reduce the risk of heart failure (HF) remains controversial. The present study evaluates the association between statin use and HF in patients with atrial fibrillation.

Methods and Results
Patients with newly diagnosed atrial fibrillation from 2010 to 2018 were included. An inverse probability of treatment weighting was used to balance baseline covariates between statin users (n=23 239) and statin nonusers (n=29 251). The primary outcome was incident HF. Cox proportional hazard models with competing risk regression were used to evaluate the risk of HF between statin users and nonusers. The median age of the cohort was 74.7 years, and 47.3% were women. Over a median follow‐up of 5.1 years, incident HF occurred in 3673 (15.8%) statin users and 5595 (19.1%) statin nonusers. Statin use was associated with a 19% lower risk of HF (adjusted subdistribution hazard ratio, 0.81 [95% CI, 0.78–0.85]). Restricted to the statin users, duration of statin use was measured during follow‐up; compared with short‐term use (3 months to <2 years), there was a stepwise reduction in the risk of incident HF among those with 2 to <4 years of statin use (subdistribution hazard ratio, 0.86 [95% CI, 0.84–0.88]), 4 to <6 years of statin use (subdistribution hazard ratio, 0.74 [95% CI, 0.72–0.76]), and ≥6 years of statin use (subdistribution hazard ratio, 0.71 [95% CI, 0.69–0.74]). Subgroup analysis showed consistent reductions in the risk of HF with statin use.

Conclusions
Statin use was associated with a decreased risk of incident HF in a duration‐dependent manner among patients with atrial fibrillation.
Trois notes sur le texte des fragments historiques d’Hilaire de Poitiers (Fragmenta ex opere historico, B, II, 9, 6, 2 ; 11, 2)
Authors: Guignard Christophe 
Published: November 2023

Abstract
The text of Hilary of Poitiers’ Historical Fragments (Fragmenta ex opere historico, CPL 436) is affected by numerous textual corruptions. This short article discusses three problems in two difficult passages in the section on the Nicene Creed and another creed, which Hilary denounces as crypto-Arian (B, II, 9, 6, 2, p. 149, 15-21; 11, 2, p. 151, 20-152, 2).
“Take the Pickaxe of Your Understanding and Dig!”
Authors: Mairhofer Elisabeth 
Published: November 2023

Abstract
In the late Middle Ages, Christine de Pizan contributed decisively to the development of Renaissance humanist ideas, which later resulted in the principle of the Enlightenment. In The Book of the City of Ladies, she laid the foundation for establishing a self-determined way of thinking that did not rely on authorities in the search for truth, but on the individual mind and one’s own experience as primary sources of knowledge—she urged people to have the courage to use their own senses. This now famous appeal is mainly and primarily associated with Kant and the Enlightenment, although de Pizan had already formulated a similar postulate 380 years earlier. The study of de Pizan also provides evidence that ideas of (early) female thinkers are partly integrated into the (philosophical) work of later male thinkers and sold as their own sole intellectual property. Only by determining the role of women in (philosophical) history do such facts become clear.
From Civilisational Encounter to Microhistories: Putting Western Learning in Local Places
Authors: Wu Huiyi 
Published: November 2023

Abstract
Western Learning has long been conceptualised as an intellectual encounter between Chinese and Western civilisations, an approach exemplified by Joseph Needham and Jacques Gernet’s classical works. Today, this framework is no longer satisfactory. As an alternative, we advocate a microhistorical approach, which historians of Catholicism have fruitfully used to reveal the plurality of local, regional and global networks that made Catholicism possible in particular places. Similar microanalysis allows the history of Western Learning to reconceptualise the Jesuits’ European traditions materially through the circulation of books, and to separate the Chinese reaction into the two geographically, chronologically, and socially distinct models of patronage, driven respectively by late Ming literati and by the early and mid-Qing court. We suggest further research on the circulation of Western Learning beyond Beijing and Jiangnan in the eighteenth century, particularly in the peripheral regions of the empire and in the rural textual culture of Catholic communities.
Rock Art Surveys in the Sudanese Eastern Desert: Results of the 2018–2019 Atbai Survey Project
Authors: Cooper Julien , Vanhulle Dorian 
Published: November 2023

The Sudanese Eastern Desert or the ‘Atbai’ is still largely unexplored from the point of view of rock art surveys. As part of the Atbai Survey Project’s fieldwork program, surveys conducted in 2018 and 2019 identified new rock art sites in the deserts around Gebel Nahoganet. Findings included a large tableau of a boat ‘fleet’ along with numerous sites yielding faunal rock art and surface remains. While a generalized boat motif is relatively commonplace in the corpus of rock art from Egypt and Nubia, this specific type of boat encountered in this distant desert exhibits a number of unique features. Notably, the tableau is carved within the walls of a natural tunnel and the features and manner of its execution have few parallels elsewhere. This contribution introduces the hypothesis that these boat motifs may have been the products of local Nubian groups including the A-Group horizon ( c. 3800–3100 BCE).[Formula: see text]
Sotagliflozin: Efficacy, Safety, and Potential Therapeutic Applications in Heart Failure
Authors: Long Allissa , Salvo Marissa 
Published: November 2023

Objective: To describe the pharmacology, clinical efficacy, and safety evidence of sotagliflozin, the first approved dual inhibitor of sodium-glucose cotransporter (SGLT) 1 and SGLT2, in heart failure (HF) management. Data sources: A literature search of studies published between January 2012 and September 2023 were identified using PubMed, MEDLINE, and clinicaltrials.gov with search terms of “sotagliflozin,” “Inpefa,” or “LX4211.” Study selection and data extraction: All available studies in English were considered. Studies were included if they investigated drug pharmacology, efficacy, or safety information. Data synthesis: Two phase 3 trials of sotagliflozin, SOLOIST-WHF and SCORED, evaluated sotagliflozin compared with placebo in patients with type 2 diabetes mellitus (T2DM). SOLOIST-WHF reported a statistically decreased rate of cardiovascular and HF events with sotagliflozin (hazard ratio [HR] = 0.67, 95% CI = 0.52-0.85), while SCORED found a statistically significant decrease in incidence of cardiovascular events in patients with T2DM, chronic kidney disease (CKD), and risk factors for cardiovascular disease in patients in the sotagliflozin group (HR = 0.74, 95% CI = 0.63-0.88). Relevance to patient care and clinical practice in comparison to existing agents: While approval of sotagliflozin expands treatment options for patients with HF, the SGLT2 inhibitors, dapagliflozin and empagliflozin, have more data supporting their use in HF, additional risk reduction benefits in patients with CKD, and approval for use in T2DM. Landmark trials of sotagliflozin required a previous diagnosis of T2DM, despite the broader approved indication. Where sotagliflozin will be adopted into the treatment of HF is unclear due to the evidence and benefits of already established SGLT2 inhibitors and the need for comparison with SGLT2 inhibitors. Conclusion: Given the limitations of currently available evidence, including difficulty in fully interpreting the trial results due to changes in primary endpoints, not adjudicating the events, and not reaching the original power calculations, more investigation is warranted to determine the benefit of sotagliflozin compared with SGLT2 inhibitors.