bluuebunny/crossref_metadata_2025_split huggingface dataset:
Effect of Tb3+ and Ce3+ co-doping on the structural stability and photoluminescence properties of hexagonal boron nitride phosphors
Authors: Nie Lunshuai , Jia Kai , Guo Hongguang , He Jiaqin , Weng Zhehui , Li Yizhou , Ju Haidong 
Published: January 2024

Abstract
In the paper, we have successfully prepared hexagonal boron nitride (h-BN) phosphors with melamine as the nitrogen source. The X-ray powder diffraction patterns confirm that the sample possesses a hexagonal crystal structure within the Pm2 space group. It is interesting that the co-doping combination of Tb3+ and Ce3+ can markedly enhance the threshold concentration of doped activators within the limited solid solution of h-BN phosphors. Under 302 nm excitation, the h-BN:Ce3+ phosphors exhibit broadband blue light emission at 406 nm. In h-BN:Tb3+, Ce3+ phosphors, the co-doping of Ce3+ not only ensures high phase purity but also results in strong green light emission. The energy transfer efficiency from Ce3+ to Tb3+ is about 55%. The fluorescence lifetime increases with the increase of Ce3+ and Tb3+ concentration, and the fluorescence lifetime of h-BN:0.025Tb3+, 0.05Ce3+ phosphor reached 2.087 ms. Additionally, the h-BN:0.025Tb3+, 0.05Ce3+ phosphor exhibits excellent thermal performance with an activation energy value of 0.2825 eV. Moreover, the photoluminescence quantum yield of the sample exceeds 52%. Therefore, the h-BN:Tb3+, Ce3+ samples can be used as green phosphors for solid state lighting and fluorescent labeling.
Analysis of Rescue Strategies for Acute Thrombosis in Moyamoya Patients during STA-MCA Bypass Surgery and the Literature Review
Authors: Xu Haitao , Ni Haojin , Zhou Chenhui , Wang Xinwen , Wei Jie , Qian Tiansheng , Dai Zifeng , Lan Wenting , Wu Xin , Yu Jiacheng , Li Xianru , Gao Xiang , Xu Bin , Lin Jinghui 
Published: January 2024

Abstract
Background and objectives: Moyamoya disease is most improtantly treated with superficial temporal artery to middle cerebral artery (STA-MCA) bypass surgery, and the intraoperative patency of the reconstructive vessels is critical to the efficacy of the procedure. This study aimed to evaluate the efficacy of intra-arterially infused tirofiban for the treatment of acute thrombosis during STA-MCA bypass surgery and countermeasures for acute thrombosis.
Methods: We retrospectively reviewed the clinical and imaging data, surgical procedure, and follow-up outcomes of eight patients who developed acute thrombosis during the surgical procedure. We implemented the different thrombolytic methods to evaluate the optimal thrombosis management during the bypass surgery. After three months, we assessed neurological functions using the modified Rankin Scale (mRS) and conducted a literature review using PubMed.
Results: Eight patients (four male patients and four female patients) developed acute thrombosis during the bypass surgery. Of the eight patients, two underwent re-anastomosis after thrombus removal, three received local injections of tirofiban into the anastomosis or the branches of the superficial temporal artery, and three underwent superselective intra-arterial tirofiban infusion using a microcatheter. Thrombosis were resolved, and arteries were recanalized in all patients. The mRS score was 0 in all patients. No major ischemic or hemorrhagic complications occurred.
Conclusion: Our treatment methods were efficacious in the management of acute thrombosis. Intra-arterial tirofiban administration seems to be a simple and effective treatment option for acute thrombosis during STA-MCA bypass surgery.
Multi-physical field coupled mixed lubrication analysis of hydraulic reciprocating VL Seal
Authors: Zhao Yan , Feng Ziming , Liu Weikai 
Published: January 2024

Abstract
Engineering practice has demonstrated that seal failure can result in severe leakage and wear, reducing the efficiency of hydraulic systems and even leading to major safety accidents. Currently, there is relatively limited analysis of the thermal aspect of seal interfaces, with most studies focusing on the mechanical analysis. However, in actual applications, temperature has a significant impact on sealing performance. In this paper, nonlinear elastomechanics, viscous fluid mechanics, micro-contact mechanics, micro-deformation theory, and thermodynamics are coupled to establish a mixed lubrication model considering the thermal effect. The reliability of the mixed lubrication model is verified through experiments, and the temperature distribution of the oil film in the sealing area and the temperature distribution of the seal ring are simulated. Finally, the effects of reciprocating speed, root mean square roughness, and seal ring interference on seal friction force and leakage are investigated.The results show that the heat generated in the sealing area accumulates at the bottom of the V-ring. Under the same conditions, compared with the inner stroke, the temperature rise area of the outer stroke is biased to the left and has a higher temperature rise. In addition, the piston rod speed and the interference of the seal ring have a greater impact on the overall seal friction force and leakage, while at a low interference, the root mean square roughness has a significant impact on the outer stroke of the piston rod, but a limited impact on the inner stroke.
Assessment of ATP Metabolism to Adenosine by Ecto-Nucleotidases Carried by Tumor-Derived Small Extracellular Vesicles
Authors: Hong Chang-Sook , Menshikova Elizabeth V. , Whiteside Theresa L. , Jackson Edwin K. 
Published: January 2024

Abstract

Background Immunosuppression is a hallmark of cancer progression. Tumor-derived small extracellular vesicles (sEV), also known as TEX, produce adenosine (ADO) and can mediate tumor-induced immunosuppression.Methods Here, the ATP pathway of ADO production (ATP◊ADP◊AMP◊ADO) by ecto-nucleotidases carried in sEV was evaluated by a novel method using N6-etheno-ATP (eATP) and N6-etheno-AMP (eAMP) as substrates. The “downstream” N6-etheno-purines (ePurines) were measured by high performance liquid chromatography with fluorescence detection (HPLC-FL).Results Human melanoma cell-derived TEX (MTEX) metabolized eATP to N6-etheno-ADP (eADP), eAMP and N6-etheno-Adenosine (eADO) more robustly than control keratinocyte cell-derived sEV (CEX); due to accelerated conversion of eATP to eADP and eADP to eAMP. MTEX and CEX similarly metabolized eAMP to eADO. Blocking of the ATP pathway with the selective CD39 inhibitor ARL67156 or pan ecto-nucleotidase inhibitor POM-1 normalized the ATP pathway but neither inhibitor completely abolished it. In contrast, inhibition of CD73 by PSB12379 or AMPCP abolished eADO formation in both MTEX and CEX, suggesting that targeting CD73 is the preferred approach to eliminating ADO produced by sEV.Conclusions The noninvasive, sensitive, and specific assay assessing ePurine metabolism ± ecto-nucleotidase inhibitors in TEX enables the personalized identification of the ecto-nucleotidase primarily involved in ADO production in patients with cancer. The assay could guide precision medicine by determining which purine is the preferred target for inhibitory therapeutic interventions.
Scientific civility and academic performance
Authors: Camacho Emma , Dragotakes Quigly , Hartshorn Isabella , Casadevall Arturo , Buccino Daniel L 
Published: January 2024

Abstract
In modern science, interdisciplinary and collaborative research is encouraged among scientists to solve complex problems. However, when the time comes to measure an individual’s academic productivity, collaborative efforts are hard to conceptualize and quantify. In this study, we hypothesized that a social behavior coined “scientific civility”, which encompasses civility, collaboration, cooperation, or a combination of these, enhances an individual’s productivity influencing their academic performance. To assess the value of collaborative efforts and research output to a scientist’s academic performance, we developed a new indicator: the C score. We examined publicly available data from 1000 academic scientists at the individual-level, focusing on their scholarly output and collaborative networks as a function of geographic distribution and time. Our findings strongly suggest that the C score supports an integrative and holistic assessment of an individual’s academic performance. This indicator may be used as a decision-making tool to track career advancement within the academic environment.
Hepatic failure with Providencia rettgeri infection: case report
Authors: Yan Fangfei , Xi Dong , Han Meiwen , Guan Qianting , Guo Qinghao , Ning Qin 
Published: January 2024

Abstract
Background
Providencia rettgeri is an uncommon opportunistic pathogen of nosocomial infection in humans. It often occurs in urinary tract infection and skin damage.Few reports find providencia rettgeri infection in a hepatic failure patient.
Case presentation:
A 29 years old man admitted to us with crushing injury by a falling objects in construction site, which caused hepatorrhexis and hepatic failure .In the therapy period of infective intensive care unit (ICU), the patient got tracheal intubation to support breath and the rinse of fiber bronchoscopy cultured providencia rettgeri .
Conclusions
Providencia rettgeri is associated with the patients with totally terribble health conditionos, like post-enormous sugeries,large area skin burn and liver failure and so on. Few clincal cases also find the patients with assisted ventilation get infected with providencia rettgeri. And due to the pathogen’s character of antimicrobial resistance,it rasies mortality and prolongs recovery time. Thereafter,attention should be taken to those patients in their recovery period.
The effects of aquatic exercise on motor skills and social behaviors in children and adolescents with autism spectrum disorder: A Systematic review
Authors: Salar Sarvin , jorgic Bojan , Stojanovic Stefan , Pourgholi Maryam , Block Martin E 
Published: January 2024

Abstract
Purpose: Children and adolescents with autism spectrum disorder (ASD) have delays in developing motor skills and social behaviors compared to typically developed children. Various exercise program can improve social and motor behaviors of individuals with autism spectrum disorder. There is no consensus among researchers about how aquatic exercise effects of individuals with ASD. The purpose of this study is the comprehensively reviews the impacts of aquatic exercise on motor skills and social behaviors among children and adolescents with ASD.
Methods: This systematic review is based on the PRISMA guidelines. The following criteria was used to determine acceptance into this review: the participants were children and adolescents with ASD, the experimental program was involved aquatic exercise program, and all studies were peer-reviewed English publications from 2002 to 2022.
Results: After applying exclusion criteria, a total of 9 studies were identified. Analysis indicated that various aquatic programs including hydrotherapy and traditioanl swimming activities can improve motor skill levels and social behaviors in children and adolescents with ASD. Optimal duration of aquatic programs appears to be at least 8 weeks for a minimum of two times per week for 30 minutes per session.
Conclusion: Results of this analysis suggest that physical therapists and physical educators should recommend this intervention when appropriate, and consider developing community-based aquatic exercise programs.
Exploring Furfuryl Alcohol as Carbon Coating Agent for Silicon/Graphite Anode Active Materials
Authors: Sohel Ikramul Hasan , Zengin Feyza , Ateş Mehmet Nurullah 
Published: January 2024

Abstract

In this study, we present a facile technique for producing the amorphous carbon-coated Silicon (Si) mixed with commercial graphite (Gt) as anode active material for lithium-ion batteries. The carbon is coated onto Si particles with a single-step method from a low-cost alcohol-based source, namely furfuryl alcohol. The carbon-coated Si is then mixed with the Gt and the amount of Si is varied to obtain a stable cycling performance. The best cycling performance is obtained when the Si@C weight ratio with respect to Gt is adjusted to 10%. The cell containing the optimized Si@C anode able to deliver 415 mAh/g capacity after 100 cycles at 0.2C rate while the commercial state-of-the-art Gt anode only delivers a capacity of 303.9 mAh/g after 100 cycles. The materials are further characterized by Fourier-transform infrared (FTIR) spectroscopy, Scanning Electronic Microscopy coupled with Energy Dispersive Spectrometry (SEM/EDS), Particle Size Analyzer (PSA), Raman, X-ray Diffraction (XRD), and High-Resolution Transmission Electron Microscopy (HR-TEM) coupled with energy dispersive spectrometry and Selected Area Electron Diffraction (SAED). Electrochemical characterizations like Cyclic Voltammetry (CV) and Electrochemical Impedance Spectroscopy (EIS) analysis of the half-cells are carried out. Finally, the post-mortem analysis of the cells is carried out using SEM/EDS, post-cycling CV, and EIS.
Strategies for Implementing an Electronic Patient-Reported Outcomes-Based Symptom Management Program Across Six Cancer Centers
Authors: Hassett Michael J. , Dias Samira , Cronin Christine , Schrag Deborah , McCleary Nadine , Simpson Jaclyn , Poirier-Shelton Tiana , Bian Jessica , Reich James , Dizon Don , Begnoche Megan , Jenkins Hannah Hazard , Tasker Laura , Wong Sandra , Pearson Loretta , Paudel Roshan , Osarogiagbon Raymond U. 
Published: January 2024

Abstract

Background: Electronic patient-reported outcome (ePRO)-based symptom management improves cancer patients’ outcomes. However, implementation of ePROs is challenging, requiring technical resources for integration into clinical systems, substantial buy-in from clinicians and patients, novel workflows to support between-visit symptom management, and institutional investment.
Methods: The SIMPRO Research Consortium developed eSyM, an electronic health record-integrated, ePRO-based symptom management program for medical oncology and surgery patients and deployed it at six cancer centers between August 2019 and April 2022 in a type II hybrid effectiveness-implementation cluster randomized stepped-wedge study. Sites documented implementation strategies monthly using REDCap, itemized them using the Expert Recommendations for Implementation Change (ERIC) list and mapped their target barriers using the Consolidated Framework for Implementation Research (CFIR) to inform eSyM program enhancement, facilitate inter-consortium knowledge sharing and guide future deployment efforts.
Results: We documented 226 implementation strategies: 35 ‘foundational’ strategies were applied consortium-wide by the coordinating center and 191 other strategies were developed by individual sites. We consolidated these 191 site-developed strategies into 64 unique strategies (i.e., removed duplicates) and classified the remainder as either ‘universal’, consistently used by multiple sites (N=29), or ‘adaptive’, used only by individual sites (N=35). Universal strategies were perceived as having the highest impact; they addressed eSyM clinical preparation, training, engagement of patients/clinicians, and program evaluation. Across all documented SIMPRO strategies, 44 of the 73 ERIC strategies were addressed and all 5 CFIR barriers were addressed.
Conclusion: Methodical collection of theory-based implementation strategies fostered the identification of universal, high-impact strategies that facilitated adoption of a novel care-delivery intervention by patients, clinicians, and institutions. Attention to the high-impact strategies identified in this project could support implementation of ePROs as a component of routine cancer care at other institutions.
Trial Registration

Registry: ClinicalTrials.gov
Trial Registration Number: NCT03850912
Date of Registration: February 22, 2019
Registry Record URL:
https://clinicaltrials.gov/ct2/show/NCT03850912?term=hassett&draw=2&rank=1
Predictive modeling of high-grade lung neuroendocrine neoplasms Overall survival and Cancer-specific survival based on a machine learning approach
Authors: Li Feiyang , Li Fang , Zhao Dong , Lu Haowei 
Published: January 2024

Abstract
Objective: We wished to construct a prognostic prediction model regarding high-grade lung neuroendocrine neoplasms(L-NENs) by using demographic characteristics and clinical information.
Method: The demographic characteristics and clinical data of 5268 patients with pathologically diagnosed high-grade lung neuroendocrine tumors between 2010 and 2019 were retrospectively analyzed using the Surveillance, Epidemiology and End Results (SEER) database, and a Nomogram of overall survival(OS) and cancer-specific survival(CSS) at 1, 3, and 5 years was constructed using LASSO regression and COX regression analysis. Nomogram of OS and CSS at 1, 3, and 5 years were constructed, and the performance of the predictive models was evaluated using the consistency index (C-index), calibration curves, Receiver Operating Characteristic(ROC) curves, and decision curve analysis (DCA), and internal validation of our constructed models was performed by validation sets.
Results: We divided the included patients into training and validation sets in a ratio of 7:3, and analysis using the chi-square test revealed no statistically significant difference between the baseline information of the two data sets (p > 0.05); The training set was analyzed using COX univariate analysis and found that gender, age, AJCC stage, whether treated or not, and distant metastasis were the influencing factors of OS, and these influencing factors were found to be independent prognostic influences of OS after further screening by including these influencing factors in LASSO regression, and we constructed a Nomogram plot of OS by including these influencing factors in COX multivariate;We used the same method to screen the independent prognostic influences affecting CSS were gender, age, race, AJCC stage, whether treated or not, bone metastasis, brain metastasis, and liver metastasis, etc., which we included in the COX multifactorial to construct a Nomogram of CSS;Validation of the OS and CSS models using ROC curves, C-indexes, calibration curves and DCA curves after construction proved the accuracy and reliability of our models.
Conclusion: This prediction model can more accurately predict the prognosis of patients with high-grade L-NENs.
Assessment of Growth Hormone and Insulin-like Growth Factor 1 in Children with Epidermolysis Bullosa Dystrophica
Authors: darouti Mohammad El , Zaki Iman Sany , Musa Noha , Sayed Hagar El 
Published: January 2024

Abstract
Epidermolysis bullosa dystrophica (EBD) is characterized by muco-cutaneous fragility with blistering, scarring and severe growth retardation attributed to many factors.
This cross-sectional study included 51 patients aged 1-12 years with EBD. Weight and height were measured, with the calculation of weight standard deviation score (SDS), height SDS, and body mass index (BMI), followed by plotting them on Egyptian growth curves. Serum levels of basal growth hormone (GH), insulin like growth factor 1 (IGF-1), hemoglobin (HB) level, erythrocyte sedimentation rate (ESR), and thyroid functions (TSH and T4) were measured. Growth hormone stimulation test was performed in 10 patients.
Weight SDS and height SDS were significantly lower than normal measurements (P< 0.05*). Growth hormone, growth hormone stimulation, and IGF-1 were significantly lower than the normal range (P< 0.05*). HB levels were significantly lower than normal, while ESR levels were significantly elevated (P <0.001*). A negative correlation was found between ESR and basal GH, and a positive correlation between ESR and IGF1.
In conclusion, children with generalized DEB have poor growth and low circulating GH and IGF-1 levels, likely due to malnutrition, anemia, and inflammation that suppresses GH/IGF-1 axis. Future treatments targeting the correction of GH and IGF1 levels and anti-inflammatory treatment should be considered.
Comparison of MELD Score Subcomponents versus Post-Transjugular Intrahepatic Portosystemic Shunt (TIPS) Survival Time
Authors: Hasan Eusha , Lamba Ashley , Rumball Ian , Davoudzadeh Ethan , Tiwary Nayan , Giammarino Alexa , Greben Craig , Satapathy Sanjaya , Weinstein Jonathan 
Published: January 2024

Abstract
Background:
Consequences of severe liver disease include hepatic biosynthetic and metabolic dysfunction, which is reflected in the model for end-stage liver disease (MELD) score subcomponents of elevated international normalized ratio (INR) and bilirubin. Hepatorenal complications also occur, indicated by increased serum creatinine in the MELD score. Serum creatinine should theoretically not be a strong predictor of survival after trans-jugular intrahepatic portosystemic shunt (TIPS) placement, as TIPS directly reduces portal hypertension but cannot correct irreversible damage to hepatic metabolic processes. We compared TIPS outcomes in chronic liver disease patients whose high MELD scores were caused primarily by elevated INR/Bilirubin versus patients whose MELD scores were caused primarily by elevated creatinine.
Methods:
This retrospective study identified 68 patients undergoing primary TIPS for chronic liver disease from 2018 to 2021. Patient characteristics, baseline MELD score, and MELD subcomponents were analyzed against post-TIPS survival time.
Results:
Baseline MELD (HR = 1.136, p = 0.002), total bilirubin (HR = 1.933, p < 0.001), and INR (HR = 4.107, p = 0.004) were found to be significant predictors of decreased survival following TIPS. Baseline creatinine was not found to be significantly related to survival time (HR = 1.654, p = 0.1726).
Conclusions:
Post-TIPS survival is negatively impacted by abnormalities of MELD subcomponents related to decreased hepatic biosynthetic function (INR, total bilirubin), but not subcomponents related to portal hypertension (creatinine) which TIPS directly alleviates. This differs from the original description of the scoring system, in which creatinine was shown to be an independent predictor of post-TIPS survival.