bluuebunny/crossref_metadata_2025_split huggingface dataset:
The APOGEE value-added catalogue of Galactic globular cluster stars
Authors: Schiavon Ricardo P , Phillips Siân G , Myers Natalie , Horta Danny , Minniti Dante , Allende Prieto Carlos , Anguiano Borja , Beaton Rachael L , Beers Timothy C , Brownstein Joel R , Cohen Roger E , Fernández-Trincado José G , Frinchaboy Peter M , Jönsson Henrik , Kisku Shobhit , Lane Richard R , Majewski Steven R , Mason Andrew C , Mészáros Szabolcs , Stringfellow Guy S 
Published: October 2023

ABSTRACT
We introduce the Sloan Digital Sky Survey (SDSS)/ Apache Point Observatory Galactic Evolution Experiment (APOGEE) value-added catalogue of Galactic globular cluster (GC) stars. The catalogue is the result of a critical search of the APOGEE Data Release 17 (DR17) catalogue for candidate members of all known Galactic GCs. Candidate members are assigned to various GCs on the basis of position in the sky, proper motion, and radial velocity. The catalogue contains a total of 7737 entries for 6422 unique stars associated with 72 Galactic GCs. Full APOGEE DR17 information is provided, including radial velocities and abundances for up to 20 elements. Membership probabilities estimated on the basis of precision radial velocities are made available. Comparisons with chemical compositions derived from the GALactic Archaeology with HERMES (GALAH) survey, as well as optical values from the literature, show good agreement. This catalogue represents a significant increase in the public data base of GC star chemical compositions and kinematics, providing a massive homogeneous data set that will enable a variety of studies. The catalogue in fits format is available for public download from the SDSS-IV DR17 value-added catalogue website.
3D global simulations of accretion onto gap-opening planets: implications for circumplanetary disc structures and accretion rates
Authors: Li Ya-Ping , Chen Yi-Xian , Lin Douglas N C 
Published: October 2023

ABSTRACT
We perform a series of 3D simulations to study the accretion of giant planet embedded in protoplanetary discs (PPDs) over gap-opening time-scales. We find that the accretion mass flux mainly comes from the intermediate latitude above the disc mid-plane. The circumplanetary disc (CPD) for a super-thermal planet is rotation-supported up to ∼20–30 per cent of the planet Hill radius. While both mass inflow and outflow exists in the CPD mid-plane, the overall trend is an outflow that forms a meridional circulation with high-latitude inflows. We confirm the absence of accretion outburst from disc eccentricity excited by massive planets in our 3D simulations, contrary to the consensus of previous 2D simulations. This suggests the necessity of 3D simulations of accretion even for super-Jupiters. The accretion rates of planets measured in a steady state can be decomposed into the ‘geometric’ and ‘density depletion’ factors. Through an extensive parameter survey, we identify a power-law scaling for the geometric factor $\propto q_{\rm th}^{2/3}$ for super-thermal planets (qth being the thermal mass ratio), which transform to $\propto q_{\rm th}^{2}$ for less massive cases. The density depletion factor is limited by the disc accretion rate for mildly super-thermal planets and by gap-opening for highly super-thermal ones. Moderate planetary eccentricities can enhance the accretion rates by a factor of 2–3 by making the gap shallower, but it does not impact the flow geometry. We have applied our simulations results to accreting protoplanet system PDS 70 and can satisfactorily explain the accretion rate and CPD size in observations.
Flat patterns in cosmic structure
Authors: Peebles P J E 
Published: October 2023

ABSTRACT
It is natural to wonder how far the flat pattern in the distribution of galaxies and clusters of galaxies around the de Vaucoueurs Local Supercluster extends, and whether there are other similarly extended flat patterns in the large-scale structure of the Universe. I present evidence of two extended flat and thin sheet-like patterns in the distributions of galaxies and clusters detected at redshift z &lt; 0.021. Sheet A contains our position and is tilted 11° from the supergalactic pole, meaning the Local Supercluster is a moderately bent part of the more extended Sheet A. The continuation of this sheet is detected in the disjoint sample of galaxies at redshifts 0.021 &lt; z &lt; 0.041 and again in the disjoint samples of galaxies and clusters of galaxies at 0.042 &lt; z &lt; 0.085. Sheet B is 15 Mpc from us at its closest point. It is detected at z &lt; 0.021 and at 0.021 &lt; z &lt; 0.041. These results make a serious case for the reality of signatures of close to flat and thin extended sheet-like patterns in cosmic structure, and an interesting challenge for the lambda-cold dark matter cosmology.
fried v2: a new grid of mass-loss rates for externally irradiated protoplanetary discs
Authors: Haworth Thomas J , Coleman Gavin A L , Qiao Lin , Sellek Andrew D , Askari Kanaar 
Published: October 2023

ABSTRACT
We present a new fried grid of mass-loss rates for externally far-ultraviolet (FUV) irradiated protoplanetary discs. As a precursor to the new grid, we also explore the microphysics of external photoevaporation, determining the impact of polycyclic aromatic hydrocarbon (PAH) abundance, metallicity, coolant depletion (via freeze out and radial drift), and grain growth (depletion of small dust in the outer disc) on disc mass-loss rates. We find that metallicity variations typically have a small effect on the mass-loss rate, since the impact of changes in heating, cooling and optical depth to the disc approximately cancel out. The new fried grid therefore focuses on (i) expanding the basic physical parameter space (disc mass, radius, UV field, stellar mass), (ii) on enabling variation of the the PAH abundance, and (iii) including an option for grain growth to have occurred or not in the disc. What we suggest is the fiducial model is comparable to the original fried grid. When the PAH-to-dust ratio is lower, or the dust in the wind more abundant, the mass-loss rate can be substantially lower. We demonstrate with a small set of illustrative disc evolutionary calculations that this in turn can have a significant impact on the disc mass/radius/ evolution and lifetime.
Formation of misaligned second-generation discs through fly-by encounters
Authors: Smallwood Jeremy L , Nealon Rebecca , Cuello Nicolás , Dong Ruobing , Booth Richard A 
Published: October 2023

ABSTRACT
Observations reveal protoplanetary discs being perturbed by fly-by candidates. We simulate a scenario where an unbound perturber, i.e. a fly-by, undergoes an inclined grazing encounter, capturing material and forming a second-generation protoplanetary disc. We run N-body and three-dimensional hydrodynamical simulations of a parabolic fly-by grazing a particle disc and a gas-rich protoplanetary disc, respectively. In both our N-body and hydrodynamic simulations, we find that the captured, second-generation disc forms at a tilt twice the initial fly-by tilt. This relationship is robust to variations in the fly-by’s tilt, position angle, periastron, and mass. We extend this concept by also simulating the case where the fly-by has a disc of material prior to the encounter but we do not find the same trend. An inclined disc with respect to the primary disc around a misaligned fly-by is tilted by a few degrees, remaining close to its initial disc tilt. Therefore, if a disc is present around the fly-by before the encounter, the disc may not tilt up to twice the perturber tilt depending on the balance between the angular momentum of the circumsecondary disc and captured particles. In the case where the perturber has no initial disc, analysing the orientation of these second-generation discs can give information about the orbital properties of the fly-by encounter.
Effect of the extended dosing interval of anti-TNF-α NANOBODY® compound ozoralizumab in patients with low disease activity rheumatoid arthritis
Authors: Takeuchi Tsutomu , Nakanishi Megumi , Kawanishi Masafumi , Yamasaki Hironori , Tanaka Yoshiya 
Published: October 2023

ABSTRACT

Objectives
This article aims to evaluate the effect of the extended dosing interval on the efficacy and safety of ozoralizumab in patients with rheumatoid arthritis (RA).

Methods
In a long-term extension study (HOSHIZORA trial) for patients who had completed a phase II/III study with methotrexate or a phase III study without methotrexate, the dosing interval of ozoralizumab was allowed to extend from every 4 weeks (Q4W) to every 8 weeks (Q8W), at the physician’s discretion, for patients who had maintained a 28-joint disease activity score based on erythrocyte sedimentation rate (DAS28-ESR) &lt;3.2 at the last two time points. The continuation rate, efficacy, and safety were examined in patients who had completed 24 weeks after the change in the dosing interval by the data cut-off point.

Results
Of the 32 patients who maintained DAS28-ESR &lt;3.2 and changed the interval from Q4W to Q8W, 28 (87.5%) remained on Q8W for 24 weeks. At Week 24, the percentages of patients who remained on Q8W and achieved DAS28-ESR &lt;2.6 and &lt;3.2 were 71.9% and 84.4%, respectively. No safety concerns were observed for 24 weeks in the Q8W group.

Conclusions
In patients with RA and maintained DAS28-ESR &lt;3.2 with ozoralizumab, efficacy was sustained and well tolerated after the dosing interval was extended from Q4W to Q8W.
Copper isotope ratios in serum do not track cancerous tumor evolution, but organ failure
Authors: Miaou Emily , Tissot François L H 
Published: October 2023

Abstract
Relative to healthy controls, lighter copper isotopic compositions have been observed in the serum of breast cancer and end-stage liver disease patients, raising the possibility that Cu isotope ratios could be used as a tracer for disease progression. Here, we assess the potential of natural Cu isotopic variations (expressed as δ65Cu) as diagnostic tools for cancer progression and/or liver failure by performing a first-order analysis of Cu isotopic cycling in the human body. Using a box model, we simulate the kinetics of Cu mass transfer throughout significant reservoirs in the body, allowing isotopic fractionation to occur during Cu uptake/release from these reservoirs. With this model, we determine under which conditions the serum δ65Cu values would reflect perturbation related to cancer growth and/or liver failure at a level resolvable with modern mass spectrometry. We find that tumor growth alone is unable to explain the light isotopic signature observed in serum. Instead, we find that metabolic changes to the liver function resulting in a ∼1‰ isotope fractionation during Cu uptake from the blood into the liver can readily explain the long-term serum isotopic shift of ∼0.2‰ observed in cancer patients. A similar fractionation (∼1.3‰) during Cu uptake into the liver also readily explains the −1.2‰ shift observed in the serum of cirrhosis patients with ascites, suggesting a potentially common driver of isotopic fractionation in both cases. Using this model, we then test hypotheses put forward by previous studies and begin to probe the mechanisms behind the measured isotopic compositions.
Efficacy and Safety of Cefmetazole for Bacteremia Caused by Extended-Spectrum β-Lactamase–Producing Enterobacterales vs Carbapenems: A Retrospective Study
Authors: Kashihara Eriko , Sada Ryuichi Minoda , Tsugihashi Yukio , Obayashi Hitoshi , Nakamura Akihiro , Abe Noriyuki , Miyake Hirofumi , Akebo Hiroyuki 
Published: October 2023

Abstract

Background
Extended-spectrum β-lactamase (ESBL)–producing Enterobacterales have become a global concern owing to increased infections, high mortality, and limited antibiotic treatment options. Carbapenems (CPMs) are effective against ESBL-producing Enterobacterales, but their overuse leads to the emergence of multidrug-resistant bacteria. Cefmetazole (CMZ) is effective in vitro; however, its clinical efficacy remains unclear.

Methods
We retrospectively reviewed patients who were treated with CMZ or CPMs for bacteremia caused by ESBL-producing Enterobacterales between 1 April 2014 and 31 September 2022 at Tenri Hospital. The primary outcome measure was 90-day mortality. We also evaluated resistance genes and sequence types of ESBL-producing Enterobacterales.

Results
In total, 156 patients were enrolled in this study. Ninety patients (58%) received CMZ therapy. Patients in the CMZ group were significantly older than those in the CPM group (median [IQR], 79 years [71–86] vs 74 years [64–83]; P = .001). The severity of the Pitt bacteremia score of the CMZ group was lower than that in the CPM group (0 [0–2] vs 2 [0–2], P = .042). Six patients (7%) in the CMZ group and 10 (15%) in the CPM group died by day 90 (P = .110). Charlson Comorbidity Index and prevalence of sequence 131 between the groups were statistically insignificant.

Conclusions
Our findings suggest that CMZ is a well-tolerated alternative to CPM for treating bacteremia caused by ESBL-producing Enterobacterales.
Use of Ceftriaxone and Benzylpenicillin in Outpatient Parenteral Antimicrobial Therapy: Spectrum vs Cost
Authors: Kalatharan L , Ferman M , Kumar S , Rajendra S , Pripanapong S , Wu Y , Richards H , Rogers B A 
Published: October 2023

Abstract

Background
The application of antimicrobial stewardship (AMS) principles may entail increased cost to allow for narrower-spectrum therapy. Prescribing benzylpenicillin (BP) and ceftriaxone (CRO) for outpatient parenteral antimicrobial therapy (OPAT) demonstrates the complex challenge of this principle. The aim of this study is to analyze the use of BP and CRO in our OPAT program, including indications and relative cost.

Methods
We analyzed all adult patients in our OPAT program who received intravenous BP or CRO over 1 year. We identified a “crossover group” of patients who could have received either agent. Economic comparison was based on acquisition cost of the therapy (drug, infuser, and preparation costs).

Results
Of 105 eligible patients, 54 (51%) and 51 (49%) received BP and CRO, respectively. Forty (38%) patients were suitable for either agent; of these, the majority (n = 31, 78%) were treated with BP. Economic analysis demonstrated that the average daily cost of BP therapy was $93.76/d (AUD) vs $1.23/d for CRO. Thus, across our OPAT programs, we had an additional average cost of $92.53/patient/d to use BP instead of CRO. Program-wide the annual additional cost of using BP and thus applying this AMS strategy was $68 386.12.

Conclusions
BP is often selected over CRO by clinicians, where possible, as recommended by the Australian guidelines; however, BP is associated with higher daily acquisition costs. More broadly, a number of narrower-spectrum agents may involve significantly higher costs than comparators; as such, the $92.53/d to prevent CRO exposure can be considered when applying other antimicrobial-substitution AMS interventions in an acute health care setting.
Transcriptional activation by WRKY23 and derepression by removal of bHLH041 coordinately establish callus pluripotency in Arabidopsis regeneration
Authors: Xu Chongyi , Chang Pengjie , Guo Shiqi , Yang Xiaona , Liu Xinchun , Sui Baofeng , Yu Dongxue , Xin Wei , Hu Yuxin 
Published: October 2023

Abstract
Induction of the pluripotent cell mass termed callus from detached organs or tissues is an initial step in typical in vitro plant regeneration, during which auxin-induced ectopic activation of root stem cell factors is required for subsequent de novo shoot regeneration. While Arabidopsis (Arabidopsis thaliana) AUXIN RESPONSE FACTOR 7 (ARF7) and ARF19 and their downstream transcription factors LATERAL ORGAN BOUNDARIES DOMAIN (LBD) are known to play key roles in directing callus formation, the molecules responsible for activation of root stem cell factors and thus establishment of callus pluripotency are unclear. Here, we identified Arabidopsis WRKY23 and BASIC HELIX-LOOP-HELIX 041 (bHLH041) as a transcriptional activator and repressor, respectively, of root stem cell factors during establishment of auxin-induced callus pluripotency. We show that auxin-induced WRKY23 downstream of ARF7 and ARF19 directly activates the transcription of PLETHORA 3 (PLT3) and PLT7 and thus that of the downstream genes PLT1, PLT2, and WUSCHEL-RELATED HOMEOBOX 5 (WOX5), while LBD-induced removal of bHLH041 derepresses the transcription of PLT1, PLT2, and WOX5. We provide evidence that transcriptional activation by WRKY23 and loss of bHLH041-imposed repression act synergistically in conferring shoot-regenerating capability on callus cells. Our findings thus disclose a transcriptional mechanism underlying auxin-induced cellular reprogramming, which, together with previous studies, outlines the molecular framework of auxin-induced pluripotent callus formation for in vitro plant regeneration programs.
Cell layer–specific expression of the homeotic MADS-box transcription factor PhDEF contributes to modular petal morphogenesis in petunia
Authors: Chopy Mathilde , Cavallini-Speisser Quentin , Chambrier Pierre , Morel Patrice , Just Jérémy , Hugouvieux Véronique , Rodrigues Bento Suzanne , Zubieta Chloe , Vandenbussche Michiel , Monniaux Marie 
Published: October 2023

Abstract
Floral homeotic MADS-box transcription factors ensure the correct morphogenesis of floral organs, which are organized in different cell layers deriving from distinct meristematic layers. How cells from these distinct layers acquire their respective identities and coordinate their growth to ensure normal floral organ morphogenesis is unresolved. Here, we studied petunia (Petunia × hybrida) petals that form a limb and tube through congenital fusion. We identified petunia mutants (periclinal chimeras) expressing the B-class MADS-box gene DEFICIENS in the petal epidermis or in the petal mesophyll, called wico and star, respectively. Strikingly, wico flowers form a strongly reduced tube while their limbs are almost normal, while star flowers form a normal tube but greatly reduced and unpigmented limbs, showing that petunia petal morphogenesis is highly modular. These mutants highlight the layer-specific roles of PhDEF during petal development. We explored the link between PhDEF and petal pigmentation, a well-characterized limb epidermal trait. The anthocyanin biosynthesis pathway was strongly downregulated in star petals, including its major regulator ANTHOCYANIN2 (AN2). We established that PhDEF directly binds to the AN2 terminator in vitro and in vivo, suggesting that PhDEF might regulate AN2 expression and therefore petal epidermis pigmentation. Altogether, we show that cell layer–specific homeotic activity in petunia petals differently impacts tube and limb development, revealing the relative importance of the different cell layers in the modular architecture of petunia petals.
NTRC and thioredoxinsm1/m2 underpin the light acclimation of plants on proteome and metabolome levels
Authors: Dziubek Dejan , Poeker Louis , Siemitkowska Beata , Graf Alexander , Marino Giada , Alseekh Saleh , Arrivault Stéphanie , Fernie Alisdair R , Armbruster Ute , Geigenberger Peter 
Published: October 2023

AbstractDuring photosynthesis, plants must manage strong fluctuations in light availability on different time scales, leading to long-term acclimation and short-term responses. However, little is known about the regulation and coordination of these processes and the modulators involved. In this study, we used proteomics, metabolomics, and reverse genetics to investigate how different light environmental factors, such as intensity or variability, affect long-term and short-term acclimation responses of Arabidopsis (Arabidopsis thaliana) and the importance of the chloroplast redox network in their regulation. In the wild type, high light, but not fluctuating light, led to large quantitative changes in the proteome and metabolome, accompanied by increased photosynthetic dynamics and plant growth. This finding supports light intensity as a stronger driver for acclimation than variability. Deficiencies in NADPH-thioredoxin reductase C (NTRC) or thioredoxins m1/m2, but not thioredoxin f1, almost completely suppressed the re-engineering of the proteome and metabolome, with both the induction of proteins involved in stress and redox responses and the repression of those involved in cytosolic and plastid protein synthesis and translation being strongly attenuated. Moreover, the correlations of protein or metabolite levels with light intensity were severely disturbed, suggesting a general defect in the light-dependent acclimation response, resulting in impaired photosynthetic dynamics. These results indicate a previously unknown role of NTRC and thioredoxins m1/m2 in modulating light acclimation at proteome and metabolome levels to control dynamic light responses. NTRC, but not thioredoxins m1/m2 or f1, also improves short-term photosynthetic responses by balancing the Calvin–Benson cycle in fluctuating light.
Unequal Expenditure Switching: Evidence from Switzerland
Authors: Auer Raphael , Burstein Ariel , Lein Sarah , Vogel Jonathan 
Published: October 2023

Abstract
What are the unequal effects of changes in consumer prices on the cost of living? In the context of changes in import prices (driven by, e.g. changes in trade costs or exchange rates), most analyses focus on variation across households in initial expenditure shares on imported goods. However, the unequal welfare effects of non-marginal foreign price changes also depend on differences in how consumers substitute between imported and domestic goods, on which there is scant evidence. Using data from Switzerland surrounding the 2015 appreciation of the Swiss franc, we provide evidence that lower-income households have higher price elasticities. We quantify the contribution of heterogeneous elasticities for the unequal welfare effects of observed price changes between 2014 and 2015 and for counterfactual shocks to the mean and dispersion of import price changes.