bluuebunny/crossref_metadata_2025_split huggingface dataset:
Sodium–Glucose Cotransporter-2 Inhibitor, Empagliflozin, Suppresses the Inflammatory Immune Response to Influenza Infection
Authors: Constantinesco Nicholas J , Chinnappan Baskaran , DeVito Louis J , Moras Crystal , Srikanth Sashwath , Garcia-Hernandez Maria de la Luz , Rangel-Moreno Javier , Gopal Radha 
Published: December 2023

Abstract
Influenza is a highly contagious, acute respiratory disease that causes significant public health and economic threats. Influenza infection induces various inflammatory mediators, IFNs, and recruitment of inflammatory cells in the host. This inflammatory “cytokine storm” is thought to play a role in influenza-induced lung pathogenesis. Empagliflozin is a drug primarily used to lower blood glucose in type II diabetes patients by inhibiting the sodium–glucose cotransporter-2 (SGLT-2) found in the proximal tubules in the kidneys. In this study, we have investigated the effects of empagliflozin on the pulmonary immune response to influenza infection. C57BL/6 mice (wild type) were infected with influenza A/PR/8/34 and treated with empagliflozin, and the disease outcomes were analyzed. Empagliflozin treatment decreased the expression of the inflammatory cytokines IL-1β, IL-6, and CCL2; the percentage of inflammatory monocytes and inducible NO synthase–positive macrophages; and IFN response genes Stat1 and CXCL9 during influenza infection. Further, empagliflozin treatment decreases the expression of IL-6, CCL2, and CCL5 in RAW264.7 macrophages and bone marrow–derived macrophages. However, empagliflozin treatment increased influenza viral titer during infection. Despite fostering an increased viral burden, treatment with empagliflozin decreases the mortality in wild type and high fat diet–induced atherosclerotic LDLR−/− mice. Based on our findings, empagliflozin may have therapeutic implications for use in patients to prevent lung damage and acute respiratory illness.
Primary bone lymphoma of proximal tibia presenting with pathological fracture: A case report
Authors: Ibran Mohammad , Ahmad Sohail , Aggarwal Pankaj , Uzair Ashfaque Mohd , Anwer Adnan 
Published: December 2023

Abstract
Primary bone lymphoma (PBL) is an uncommon tumor accounting for approximately 4%–5% of extranodal lymphoma and less than 2% of all non-Hodgkin’s lymphoma. Diffuse large B-cell lymphoma is the most common pathological type, comprising nearly 80% of PBL. We report a case of a 35-year-old male presented to outpatient department with a pathological fracture of the left proximal tibia secondary to primary B-cell lymphoma. Initially, the clinical presentation simulated chronic osteomyelitis, but on further workup, it comes to be a case of histopathological and immunohistochemistry confirmed primary B-cell lymphoma of the left proximal tibia. He was managed with chemotherapy. There is clinical improvement in terms of pain and swelling with no preternatural adverse effects of chemotherapy. Although the incidence of PBL is very rare, in view of good treatment response to the chemotherapy, as in our case, PBL should be kept in mind as a differential diagnosis; workup should be done accordingly by applying appropriate immunohistological markers for early diagnosis and treatment.
Affine isoperimetric inequalities on flag manifolds
Authors: Dann Susanna , Paouris Grigoris , Pivovarov Peter 
Published: December 2023

AbstractBuilding on work of Furstenberg and Tzkoni, we introduce
$\mathbf {r}$
-flag affine quermassintegrals and their dual versions. These quantities generalize affine and dual affine quermassintegrals as averages on flag manifolds (where the Grassmannian can be considered as a special case). We establish affine and linear invariance properties and extend fundamental results to this new setting. In particular, we prove several affine isoperimetric inequalities from convex geometry and their approximate reverse forms. We also introduce functional forms of these quantities and establish corresponding inequalities.
Penyelesaian Sengketa Transaksi Tanah Adat
Authors: Bandu Sri Jekan Anggun , Tjoanda Merry , Uktolseja Novyta 
Published: December 2023

This study discusses the legitimacy of customary land transactions, land ownership by conducting land transactions, the emergence of disputes from customary land transactions, and the process of resolving disputes over customary land transactions through litigation and non-litigation channels. Purposes of the Research: To find out the legitimacy of customary land transactions and find out about the dispute resolution process of customary land transactions. This study uses the Normative Law research method which is carried out by examining legal materials related to the problems being studied, using statutory and conceptual approaches, and using primary and secondary data and analyzed descriptively. Results of the Research: Basically transactions are made individually, the transaction still may not conflict with normative provisions that exist in society (requirements for the validity of the agreement/transaction; legal reasons). Because it cannot be separated from society, transactions in customary law can only be said to be valid if individual interests are balanced with the interests of society. In the process of resolving customary land transaction disputes, litigation and non-litigation can be carried out. Settlement of disputes over customary land through litigation as a settlement of disputes between parties which is carried out through examinations before judges in court institutions, in the development of the times the community's need for justice and prosperity is getting bigger. So the settlement of disputes through litigation or courts is gradually felt to be less effective, the settlement of land disputes through litigation is felt to take too long and costs quite a lot. This situation causes justice seekers to look for other alternatives, namely by resolving disputes outside the formal court process, an alternative known as dispute resolution through non-litigation channels.
EDUCATIONAL MARKET: SOCIOLOGICAL AND PROCEDURAL VIEW OF THE DEMAND OF GRADUATES OF PEDAGOGICAL UNIVERSITIES
Authors: Гостев А.Н. , Ботвиньев К.П. , Демченко Т.С. , Насакина Л.Н. 
Published: December 2023

В статье на основе результатов конкретного социологического исследования изучается процесс экономики труда, востребованности выпускников педагогических вузов на российском образовательном рынке. Обосновывается значение педагогических кадров как главного фактора прогресса государства. Раскрываются теоретические основы исследования проблемы. Представляются формальные и неформальные структуры, занимающиеся изучением востребованности и трудоустройства выпускников педагогических вузов, их правовое обеспечение. Показываются результаты исследования показателей «востребованность» и «трудоустройство» выпускников педагогических вузов. Анализируются экономические причины, затрудняющие трудоустройство выпускников вузов. Определяются сильные и слабые стороны в решении этой проблемы. По итогам исследования предлагаются выводы и практические рекомендации структурам федеральной исполнительной власти по разрешению проблем повышения уровня востребованности указанной категории граждан России.
The article, based on the results of a specific sociological study, studies the process of labor economics, the demand for graduates of pedagogical universities in the Russian educational market. The importance of pedagogical personnel as the main factor in the progress of the state is justified. The theoretical foundations of the study of the problem are disclosed. Formal and informal structures are presented, engaged in the study of the demand and employment of graduates of pedagogical universities, their legal support. The results of the study of the indicators “demand” and “employment” of graduates of pedagogical universities are shown. Economic reasons that make it difficult for university graduates to find employment are analyzed. The strengths and weaknesses in solving this problem are determined. Based on the results of the study, conclusions and practical recommendations are proposed to the structures of the federal executive branch to resolve the problems of increasing the level of demand for this category of Russian citizens.
Manifestações orais e Covid-19: revisão sistemática da literatura
Authors: Silva Daiany , Silva Tarciana , Miranda Fernando , Martins Jainy , Pires Regina 
Published: December 2023

A doença COVID-19, que se tornou uma pandemia em pouco espaço de tempo, apresenta uma ameaça grave para a saúde global. As condições bucais de pacientes com COVID-19 foram analisadas em vários estudos. Diante disso, observou-se que diversas manifestações bucais foram encontradas nesses pacientes. O objetivo deste trabalho foi realizar uma revisão de literatura sistemática sobre as manifestações bucais que podem estar associadas à doença COVID-19. A pesquisa foi realizada por meio de uma revisão sistemática nas bases de dados Bireme, PubMed e SciELO, no período de 30 de abril de 2021 a 11 de maio de 2023. A busca utilizou os descritores “COVID-19”, “coronavirus” e “oral manifestations”. Foram utilizados como critério de inclusão a presença do artigo completo disponível na íntegra e publicado nos anos de 2020 a 2023 e excluídos aqueles que não relatavam alguma manifestação da COVID-19 ou que não abordavam formas de tratamento. Foram incluídos 19 artigos. As informações foram compiladas de forma a compreender a importância de se investigar as manifestações orais em decorrência dessa doença, devido a sua importância internacional dadas às suas circunstâncias devastadoras. Concluiu-se que é notável a importância da anamnese e o exame intraoral para diagnosticar as manifestações orais nos pacientes sob suspeita ou confirmados com a COVID-19, e o diagnóstico precoce das alterações é fundamental para assegurar um suporte adequado ao paciente acometido. Mais estudos são necessários para comprovar a associação direta entre a COVID-19 e as manifestações orais relatadas.
Bruxismo como consequência do estresse pandêmico: revisão integrativa
Authors: Araújo Alanna Nyelle Santos , Thaís Santos da Cunha Carla , Calista Pires Priscila , Vilas Boas Aline de Matos , Porto Edla Carvalho Lima Porto , Almeida Igor Ferreira Borba de 
Published: December 2023

O período pandêmico com todas as suas implicações possibilitou um aumento dos níveis de estresse em parte da população, que teve como consequência a obtenção ou o agravamento do bruxismo. Objetivo: O objetivo deste artigo foi realizar uma revisão integrativa sobre como o estresse causado pela pandemia de COVID-19 influenciou no desenvolvimento do bruxismo, considerando o perfil dos indivíduos acometidos. Realizou-se uma revisão integrativa da literatura a partir da seleção de artigos publicados nas bases de dados BVS, PubMed e EBSCOhost. Para isto, a seguinte questão de pesquisa foi formulada: “Existe relação entre o bruxismo e a pandemia de COVID-19?”. A busca objetivou encontrar artigos publicados em português, espanhol e inglês, durante os anos de 2019 a 2023, utilizando os descritores “bruxismo”, “COVID-19” e “estresse psicológico” e as suas respectivas versões em inglês, juntamente com a estratégia de busca AND. Revisão de literatura: Vinte estudos foram incluídos, ficando evidente uma prevalência do bruxismo como consequência do estresse pandêmico em pessoas jovens, do sexo feminino, além de estudantes/profissionais da área da saúde. Considerações finais: Acredita-se que a pandemia de COVID-19 vivenciada entre os anos de 2019 e 2023 tenha causado e/ou exacerbado estresse, sendo este um importante fator causador do bruxismo.
Importância das Jornadas Acadêmicas na formação profissional: Percepção dos estudantes Itaúna – MG, 2022
Authors: Tatiana Letícia , Aquino Oliveira Maria Eduarda , Santos Silva Tarciana , Coeli Cançado Peixoto Pires Regina 
Published: December 2023

A realização da jornada acadêmica contribui para a formação dos estudantes, já que são encontros anuais promovidos pelos alunos universitários com o objetivo de trazer temas emergentes, com intuito de promover a formação integral desses futuros profissionais. O objetivo deste estudo é avaliar a opinião dos alunos do curso de Odontologia acerca da 43° Jornada Acadêmica da Universidade de Itaúna. O evento foi desenvolvido na Universidade de Itaúna-MG. A Metodologia da pesquisa foi realizada por meio de questionários distribuídos no último dia do evento, o que propiciou a coleta de dados dos participantes, os quais manifestaram seus pontos de vista em relação à jornada acadêmica. Os dados foram tabulados em uma planilha do Excel e analisados utilizando-se as ferramentas estatísticas do software SPSS- Statistical Package for the Social Sciences, for Windows® versão 20.0. Foram geradas tabelas de frequência e análise descritiva das variáveis. Resultados mostraram que dos 231 participantes, 162 (70,1%) afirmaram que a programação da Jornada Acadêmica Odontológica atende a todos os períodos da graduação; 177 (76,6%) achou os temas abordados interessantes; 176 (76,2%) preferirem que palestras e cursos deveriam acontecer de forma simultânea; 194 (84%) acharam relevante a apresentação de banner durante o evento; 93 (40,3%) responderam que os três dias de Jornada Acadêmica são suficientes, não sendo necessário o acréscimo de dias e 132 (57,1%) que avaliaram como ótimo o evento. Concluiu-se que essa Jornada é importante para trazer novas experiências aos profissionais e atualizações do mercado de trabalho, ampliando conhecimentos, habilidades e atitudes dentro da instituição.
Relação público-privado na Educação Especial: o terceiro setor no atendimento de estudantes com Transtorno do Espectro Autista
Authors: Souza Sharmilla Tassiana de , Yaegashi Solange Franci Raimundo , Martins Etienne Henrique Brasão , Cezário Emanuelle Tótoli de Oliveira 
Published: December 2023

O presente artigo teve como objetivo discutir a oferta do Atendimento Educacional Especializado para estudantes com o Transtorno do Espectro Autistas pelo terceiro setor. A pesquisa é de natureza qualitativa, no qual amparados na análise documental e bibliográfica, os resultados revelaram que é histórica a relação do setor privado com a Educação Especial, ganhando força com o Plano Diretor da Reforma do Aparelho do Estado, em que a configuração do papel do Estado na área social se delineou como promotor de serviços sociais para manter o controle social. Tal reforma administrativa do papel do Estado estimulou outros setores mediante a descentralização para o setor público não estatal de direitos sociais, nomeadamente na área da Educação. Desse modo, concluímos que, ao invés de priorizarem os investimentos nas instituições públicas, para que fosse ofertado e estimulado o atendimento para estudantes com o Transtorno do Espectro Autista por parte do poder público, se consolidou a terceirização desses serviços para instituições privadas, isto é para o terceiro setor.
Vigilancia epidemiológica de enfermedades bucales de población atendida en Unidades de Salud en el año 2021
Authors: Fernandez-de-Quezada Ruth Bernardina Esau , Aguirre Escobar Guillermo Alfonso , Escobar de González Wendy Yesenia , Rivas Cartagena Francisco José , Santos Anaya Stefany María 
Published: December 2023

Una de las líneas de estudio del Centro de Investigaciones de la Facultad de Odontología de la Universidad de El Salvador, es la vigilancia epidemiológica de la condición de salud bucal, siendo la encuesta nacional de salud bucal en el 2016 -2017 una de las primeras investigaciones realizadas en conjunto con el Ministerio de Salud. Siguiendo esa línea, se expone el estudio Vigilancia epidemiológica de enfermedades bucales de población atendida en Unidades de Salud en el año 2021, el cual presenta la prevalencia de enfermedades bucales, algunos factores asociados y necesidades de tratamiento. Posterior al confinamiento y distanciamiento social por la pandemia COVID -19, durante el 2021, se realizó una entrevista y examen clínico a 2000 pacientes de 5 a N años, atendidos en 20 establecimientos de salud distribuidos en diferentes regiones de El Salvador; los resultados serán la evidencia para evaluar y potenciar los planes de salud o la adopción de nuevas medidas de prevención y control. Así mismo en este sistema de vigilancia, se incluye población gestante. Del total de la población estudiada, el 74.85 % (1497) fueron del sexo femenino, de las cuales el 35.74 % fueron gestantes. El 65.11 % de los hombres y el 75.56 % de las mujeres, presentaron nivel óptimo de higiene bucal. El índice ceod/CPOD y el cariado va en aumento en relación con la edad, a los 12 años el porcentaje de niños con caries fue del 11.71 %; en el de 15 años 16.57 % y en los de 35 a 44 años el 53.71 %. En cuanto a la condición periodontal a través del CPITN las edades de 35 a 44 años el 80.68 % presentó cálculo sin bolsa periodontal. La rehabilitación protésica en general es muy baja y ningún adolescente está rehabilitado, siendo el 30.19 % de pacientes rehabilitados en las edades de 35 a 44 años.
The concept of public appeals as a sign of the objective side of the illegal act
Authors: Глуздак Г.Н. , Булгакова Л.С. 
Published: December 2023

В статье исследуется содержание понятия публичных призывов как признака административных правонарушений и преступлений, предусмотренных рядом статей КоАП РФ и УК РФ соответственно. Рассматривается соотношение данного термина с категориями «публичные действия», «пропаганда», «склонение», «подстрекательство». Делается вывод о том, что публичные призывы являются разновидностью, вербальной формой публичных действий. Формулируется авторское определение публичных призывов как побудительного обращения, выраженного в словесной форме любым способом (устным, письменным, с использованием технических средств или иным) и адресованного неопределённому кругу лиц. Отмечается необходимость внесения в КоАП РФ и УК РФ дефинитивных примечаний, которые бы раскрывали смысл данного понятия.
The article researches the content of the concept of public appeals as a sign of administrative offences and crimes provided for by a number of articles of the Code of Administrative Offences of the Russian Federation and the Criminal Code of the Russian Federation, respectively. The correlation of this term with the categories “public actions”, “propaganda”, “declension”, and “incitement” is considered. It is concluded that public appeals are a kind, a verbal form of public actions. The author's definition of public appeals is formulated as an incentive appeal expressed verbally in any way (oral, written, using technical means or otherwise) and addressed to an indefinite circle of persons. It is noted that it is necessary to make definitive notes to the Code of Administrative Offences of the Russian Federation and the Criminal Code of the Russian Federation that would reveal the meaning of this term.
Efficacy of enhanced extracorporeal counterpulsation combined with atorvastatin in the treatment of cognitive impairment after stroke
Authors: Duan Yan , Tang Hui-Xia 
Published: December 2023

BACKGROUND
Cerebral apoplexy patients are prone to cognitive impairment, and it is very important to choose appropriate treatment methods to improve their cognitive impairment after stroke.
AIM
To evaluate the effects of enhanced external counterpulsation (EECP) in conjunction with atorvastatin on cognitive function, neurotransmitter levels, and the repair of brain tissue damage in patients with cognitive impairment due to stroke.
METHODS
In this retrospective study, data from 60 patients with poststroke cognitive impairment due to stroke who were treated in our hospital from February 2021 to July 2022 were analyzed and divided into a treatment group (n = 30) and a control group (n = 30) according to the different nursing methods applied. Patients in the treatment group received EECP in addition to atorvastatin, while those in the control group received atorvastatin alone. Mini-Mental State Examination (MMSE), Montreal Cognitive Assessment (MoCA) and activities of daily living (ADL) scale scores were compared between the two groups. Additionally, the two groups were compared in terms of serum acetylcholine (ACh), acetylcholinesterase (AChE), nitric oxide (NO), endothelin-1 (ET-1), β2-microglobulin (β2-MG), glial fibrillary acidic protein (GFAP), and visinin-like protein 1 (VILIP-1) in the serum. Blood flow measurements from the anterior cerebral artery (ACA), middle cerebral artery (MCA) and posterior cerebral artery (PCA) were compared between the two groups before and after treatment, and the pulsatility index (PI) and resistance index (RI) of each artery were determined.
RESULTS
MMSE, MoCA, and ADL scores all improved in both groups following treatment, with the study group showing more improvement than the control group (P < 0.05). After treatment, there were statistically significant increases in both ACh and NO levels, whereas decreases occurred in AChE, ET-1, β2-MG, VILIP-1, and GFAP, levels and the PI and RI of the left-ACA, right-ACA, left-MCA, right-MCA, left-PCA, and right-PCA. The study group showed greater gains in all metrics than the control group (P < 0.05).
CONCLUSION
EECP combined with atorvastatin is effective in the treatment of cognitive impairment after stroke and can effectively improve the cognitive function, neurotransmitter levels, and brain tissue damage status of patients.
Gestión pedagógica y calidad del servicio educativo en docentes de una institución educativa de Lima, 2023
Authors: Arteaga Rojas Carmen , Fernández-Monge Lida Marlene 
Published: December 2023

Introducción: El estudio se enfocó en abordar sobre la problemática existente en una institución educativa en torno a la gestión pedagógica y la calidad de servicio de los docentes.
Objetivo: Conocer la relación entre la gestión pedagógica y la calidad de servicio educativo en docentes de una institución educativa de Lima, 2023
Métodos: La metodología fue cuantitativa, de tipo básica, con diseño no experimental, correlacional, en una muestra de 150 profesores, mediante la técnica de encuesta se les aplicó dos cuestionarios para evaluar la gestión pedagógica y la calidad de servicio.
Resultados: Se hallaron niveles alto (34,7%) y destacado (62%) en la gestión pedagógica y en la calidad de servicio, predominaron los niveles buena (28,7%) y excelente (66,7%). De la contrastación de hipótesis, se obtuvo correlación significativa entre las variables. Asimismo, la gestión pedagógica se relacionó significativamente con las dimensiones elementos tangibles, confiabilidad, empatía y capacidad de respuesta; pero no con la dimensión seguridad.
Conclusiones: Se concluye que existe correlación significativa entre las variables, así como la gestión pedagógica con las dimensiones de la calidad de servicio, salvo con seguridad, donde no se halló vínculo.
VN-verdrag Handicap en de eigen betalingen en eigen bijdragen in het Nederlandse zorgsysteem
Authors: van Hoeve M.Ph.H. 
Published: December 2023

VN-verdrag Handicap en de eigen betalingen en eigen bijdragen in het Nederlandse zorgsysteem
Dit artikel onderzoekt de stapeling van zorgkosten voor mensen met een beperking. Waar bestaat deze stapeling uit, hoe ontstaat de stapeling en hoeverre ondervinden mensen met een levenslange en levensbrede beperking hier last van? Dit wordt uitgelegd aan de hand van voorbeelden uit de praktijk. Vervolgens gaat het artikel in op hoe deze stapeling van zorgkosten zich verhoudt tot het VN-verdrag Handicap. Het VN-verdrag Handicap geeft in diverse artikelen een kader voor participatie in de samenleving. Dat gaat onder andere over het recht op persoonlijke assistentie en wie de kosten daarvan moet dragen. Waartoe is de overheid verplicht in de ondersteuning van mensen met een beperking? Is het passend dat hoge zorgkosten in verband met een handicap of chronische ziekte voor eigen rekening komen? Het artikel sluit af met een beantwoording van de vraag: ‘wat is er nodig om de eventuele onrechtvaardigheden veroorzaakt door het systeem, op te heffen.’