bluuebunny/crossref_metadata_2025_split huggingface dataset:
Species and ecological communities as management surrogates for threatened biodiversity
Authors: Olivares-Rojas Javiera , Cook Carly N. , Ward Michelle S. , Walsh Jessica C. 
Published: February 2024

AbstractIn the face of the ongoing biodiversity crisis and limited conservation funding, surrogate approaches have become a valuable tool to represent biodiversity. Management surrogates are those that indirectly benefit an ecological system or species by representing the management requirements of co-occurring biodiversity. Recent findings highlight the cost-effective potential of surrogate species in managing threatened species, however, evaluating higher levels of biodiversity as management surrogates remains unexplored. Here, we sought to maximize conservation outcomes for threatened species and threatened ecological communities (TECs) by prioritizing management based on overlapping distributions, threats, and costs. We describe a prioritization framework for identifying TECs that could serve as cost-effective surrogates, and compare it with prioritizing threatened species only or both species and TECs. We show that when the objective is to maximize benefits for threatened species, a community approach performs poorly due to limited geographic overlap and high costs, while prioritizing species returned 7.5 times more benefits delivered to species under the same budget. Yet, if the objective is to maximize benefits across species and TECs simultaneously, a combined approach including both as surrogates delivers the greatest benefit for the same costs as a species-only approach. Range sizes and taxonomic groups significantly influenced the priority list, with threatened invertebrates and TECs of smaller ranges more likely to be selected as surrogates. Overall, this study emphasizes the importance of incorporating accurate data on factors such as threats and costs for identifying effective management surrogates, and highlights the potential benefits of prioritizing across multiple biodiversity features.
Comparison of trastuzumab emtansine, trastuzumab deruxtecan, and disitamab vedotin in a multiresistant HER2-positive breast cancer lung metastasis model
Authors: Pourjamal Negar , Yazdi Narjes , Halme Aleksi , Joncour Vadim Le , Laakkonen Pirjo , Saharinen Pipsa , Joensuu Heikki , Barok Mark 
Published: February 2024

AbstractHuman epidermal growth factor 2 (HER2)-positive breast cancer with lung metastases resistant to targeted agents is a common therapeutic challenge. Absence of preclinical lung metastasis models that are resistant to multiple anti-HER2 targeted drugs hampers the development of novel therapies. We established a novel HER2-positive breast cancer cell line (L-JIMT-1) with a high propensity to form lung metastases from the parenteral JIMT-1 cell line by injecting JIMT-1 cells into immunodeficient SCID mice. Lung metastases developed in all mice injected with L-JIMT-1 cells, and more rapidly and in greater numbers compared with the parental JIMT-1 cells. L-JIMT-1 cells expressed more epidermal growth factor receptor and HER2 than JIMT-1 cells. L-JIMT-1 cells were resistant to all five tyrosine kinase inhibitors tested in vitro (afatinib, erlotinib, lapatinib, sapitinib, and tucatinib). When we compared JIMT-1 and L-JIMT-1 sensitivity to three HER2-targeting antibody-drug conjugates (ADCs) trastuzumab emtansine (T-DM1), trastuzumab deruxtecan (T-DXd), and disitamab vedotin (DV) in vitro, JIMT-1 cells were resistant T-DXd, partially sensitive to T-DM1, and sensitive to DV, while L-JIMT-1 cells were resistant to both T-DM1 and T-DXd, but moderately sensitive to DV. In a mouse model, all three ADCs inhibited the growth of L-JIMT-1 lung metastases compared to a vehicle, but DV and T-DXd more strongly than T-DM1, and DV treatment led to the smallest tumor burden. The L-JIMT breast cancer lung metastasis model developed may be useful in the evaluation of anti-cancer agents for multiresistant HER2-positive advanced breast cancer.
The Efficacy of Digital Help for Divorced Danes: Randomized Controlled Trial of Cooperation After Divorce (CAD) and Sick Days
Authors: Sander Søren , Strizzi Jenna Marie , Cipric Ana , Øverup Camilla Stine , Hald Gert Martin 
Published: February 2024

AbstractFew digital divorce interventions have undergone rigorous randomized control trial study (RCT) testing of their physical and psychological health effects. This paper describes the Cooperation after Divorce (CAD) intervention including background, target group, design and engagement strategies, intervention development, content, and theoretical cornerstones. The 17-module digital psychoeducational intervention addresses three main content areas: (1) the divorcee themselves, (2) the children, and (3) co-parenting. The content of the modules provided psychoeducation and therapeutic activities focused on the maladaptive interactional patterns between former partners and how to develop new interactional schemas, including a focus on when and how to communicate with the former partner in a way that does not escalate conflict. A randomized controlled trial (N = 778) assessed the effect of CAD in terms of number of sick days. Participants were assessed at 3-, 6- and 12-month post-divorce. Independent samples t test revealed that participants in the intervention group on average reported 5.82 fewer sick days one year post-divorce than did participants in the control condition. The results suggest that digital post-divorce interventions decrease sick days for newly divorce individuals, thereby offering long-term human, family, and public health benefits.
Luchando Junt@s Por Una Familia Unida (Fighting Together for a United Family): Rebuilding the Cohesive Self of Immigrant Parents and Community Healing after a Family Separation in the United States – A Self Psychology Perspective
Authors: Aguilar Cheryl 
Published: February 2024

AbstractThe Zero Tolerance policy implemented by the Trump administration resulted in the separation of thousands of Central American families seeking asylum at the U.S. Southern border. This policy has had a devastating impact on the mental health of parents and their children. While most of the literature on forced immigration family separation, and reunification focuses on children’s traumatic responses, it is essential to expand the literature to include the impact on parents, who can help mitigate the negative consequences of adverse events and traumatic stress on their children. When parents are not provided with adequate culturally sensitive healing interventions, their distress, and emotional needs may affect their ability to effectively support their children. Using a self psychology lens, this theoretical article sheds light on the psychological experiences of Central American parents who endured forced family separation. It also contributes knowledge to self psychology theory and its integration into group work with Central Americans. This article draws from the literature, my clinical experience with immigrants and refugees, and my work with Central American asylum-seeking families impacted by the “zero tolerance” immigration policy to argue that self psychology provides a lens for understanding the impact of the government’s empathic failure on parents upon entering the United States that led to a blow to parents’ cohesive self. Parents’ cohesive self can be restored with sufficient collective twinship, mirroring, and idealizing experiences, which in self-psychology are paramount psychological needs to be met for building and maintaining a strong self.
Safety and efficacy of apatinib in combination with chemotherapy with or without immunotherapy versus chemotherapy alone as first-line treatment for advanced gastric cancer
Authors: Chang Lele , Zhang Xuemei , Ma Qian , Kong Lingyang , Yu Yang , Tao Ji , Li Qingwei 
Published: February 2024

SummaryThe specific first-line regimen for advanced gastric cancer (GC) is still controversial. The benefit of apatinib for first-line treatment of advanced GC remains unknown and needs to be further explored. Eighty-two patients with advanced GC treated in our institution from October 2017 to March 2023 were retrospectively reviewed. All individuals had her-2 negative GC and had received at least two cycles of first-line treatment, including 44 patients in the combination treatment group (apatinib in combination with chemotherapy with or without immunotherapy) and 38 patients in the simple chemotherapy group. We evaluated the efficacy and safety of apatinib in combination with chemotherapy with or without immunotherapy in the first-line treatment of advanced GC by comparing the efficacy, progression-free survival (PFS), and adverse events in two groups of patients. The median PFS of the simple chemotherapy group was 9.25 months (95% confidence interval (CI), 6.1–11.2 months), and that of the combination treatment group was 10.9 months (95% CI, 7.9–15.8 months), which was 1.65 months longer than the simple chemotherapy group. Statistically significant differences are shown (P = 0.022). The objective response rate (ORR) of the combination treatment group was 65.9%, and 36.8% in the simple chemotherapy group. Statistically significant differences are shown (P = 0.014). No serious (Grade IV) adverse events occurred in either group. Our study indicates that apatinib in combination with chemotherapy with or without immunotherapy as first-line treatment for advanced GC exhibits good anti-tumor activity and is well tolerated by patients.
The role of digital capital in parental engagement
Authors: Addi-Raccah Audrey 
Published: February 2024

AbstractPrevious studies discussed the relationship between parental engagement and different forms of capital, such as cultural or social capital. The current study takes a step further by referring to digital capital. It examines the direct and mediating effects of parents' digital capital on their engagement in their children's learning. The study also compares the differences between parents of low and high socioeconomic statuses regarding the effect of digital capital on their engagement. The study sample included 600 Israeli parents with children in elementary schools who completed an anonymous online questionnaire during the COVID-19 pandemic. Descriptive statistics and structural equation modeling analysis revealed that parents with high socioeconomic status use digital capital more frequently than parents with low socioeconomic status. Further, digital capital was directly related to parental engagement and acted as a mediator between parents' socioeconomic background, social and institutionalized cultural capital, and their engagement in their children’s learning, giving an advantage to high-socioeconomic parents. However, the relationships between parental engagement and the types of capital were found to be different for low compared to high socioeconomic parents. The findings emphasize the potential of digital capital, particularly for disadvantaged groups, as a lever for improving parental engagement to benefit children and ultimately contributing toward creating a more equitable society.
Evaluating county-level lung cancer incidence from environmental radiation exposure, PM2.5, and other exposures with regression and machine learning models
Authors: Lee Heechan , Hanson Heidi A. , Logan Jeremy , Maguire Dakotah , Kapadia Anuj , Dewji Shaheen , Agasthya Greeshma 
Published: February 2024

AbstractCharacterizing the interplay between exposures shaping the human exposome is vital for uncovering the etiology of complex diseases. For example, cancer risk is modified by a range of multifactorial external environmental exposures. Environmental, socioeconomic, and lifestyle factors all shape lung cancer risk. However, epidemiological studies of radon aimed at identifying populations at high risk for lung cancer often fail to consider multiple exposures simultaneously. For example, moderating factors, such as PM2.5, may affect the transport of radon progeny to lung tissue. This ecological analysis leveraged a population-level dataset from the National Cancer Institute’s Surveillance, Epidemiology, and End-Results data (2013–17) to simultaneously investigate the effect of multiple sources of low-dose radiation (gross $$\gamma$$
γ
activity and indoor radon) and PM2.5 on lung cancer incidence rates in the USA. County-level factors (environmental, sociodemographic, lifestyle) were controlled for, and Poisson regression and random forest models were used to assess the association between radon exposure and lung and bronchus cancer incidence rates. Tree-based machine learning (ML) method perform better than traditional regression: Poisson regression: 6.29/7.13 (mean absolute percentage error, MAPE), 12.70/12.77 (root mean square error, RMSE); Poisson random forest regression: 1.22/1.16 (MAPE), 8.01/8.15 (RMSE). The effect of PM2.5 increased with the concentration of environmental radon, thereby confirming findings from previous studies that investigated the possible synergistic effect of radon and PM2.5 on health outcomes. In summary, the results demonstrated (1) a need to consider multiple environmental exposures when assessing radon exposure’s association with lung cancer risk, thereby highlighting (1) the importance of an exposomics framework and (2) that employing ML models may capture the complex interplay between environmental exposures and health, as in the case of indoor radon exposure and lung cancer incidence.
Graphical abstract
Assessment of the ecological risk and mobility of arsenic and heavy metals in soils and mine tailings from the Carmina mine site (Asturias, NW Spain)
Authors: Fernández-Martínez Rodolfo , Corrochano Noelia , Álvarez-Quintana Jessica , Ordóñez Almudena , Álvarez Rodrigo , Rucandio Isabel 
Published: February 2024

AbstractAn evaluation of the pollution, distribution, and mobility of arsenic and heavy metals in spoil heaps and soils surrounding the abandoned Carmina lead–zinc mine (Asturias, northern Spain) was carried out. Fractionation of arsenic was performed by an arsenic-specific sequential extraction method; while, heavy metal fractionations was carried out using the protocol of the Bureau Community of Reference (BCR) (now renamed Standards, Measurements and Testing Programme). Arsenic appeared predominantly associated with amorphous iron oxyhydroxides. Among the heavy metals, lead and zinc showed high availability since significant amounts were extracted in the nonresidual fractions; whereas, chromium, copper and nickel showed very low availability, indicating their lithogenic origins. The results showed that the extractability of heavy metals in soils is influenced mainly by the presence of iron and manganese oxides as well as by pH and Eh. Multiple pollution indices, including the enrichment factor (EF), geoaccumulation index (Igeo), ecological risk index (Er) and potential ecological risk index (PERI), were used to assess the degree of soil pollution in the mine area. All results showed that lead was the key factor causing the pollution and ecological risk in the studied area, and copper, zinc and arsenic also had significant contributions. Notably, the sites at higher risk coincided with those with high availability of arsenic and heavy metals. This study provides an integrative approach that serves as a powerful tool to evaluate the metal pollution status and potential threats to the local environment of abandoned mining areas, and the results are useful for making management decisions in these areas.
Citizen scientists’ engagement in flood risk-related data collection: a case study in Bui River Basin, Vietnam
Authors: Tran Huan N. , Rutten Martine , Prajapati Rajaram , Tran Ha T. , Duwal Sudeep , Nguyen Dung T. , Davids Jeffrey C. , Miegel Konrad 
Published: February 2024

AbstractTime constraints, financial limitations, and inadequate tools restrict the flood data collection in undeveloped countries, especially in the Asian and African regions. Engaging citizens in data collection and contribution has the potential to overcome these challenges. This research demonstrates the applicability of citizen science for gathering flood risk-related data on residential flooding, land use information, and flood damage to paddy fields for the Bui River Basin in Vietnam. Locals living in or around flood-affected areas participated in data collection campaigns as citizen scientists using self-investigation or investigation with a data collection app, a web form, and paper forms. We developed a community-based rainfall monitoring network in the study area using low-cost rain gauges to draw locals’ attention to the citizen science program. Fifty-nine participants contributed 594 completed questionnaires and measurements for four investigated subjects in the first year of implementation. Five citizen scientists were active participants and contributed more than 50 completed questionnaires or measurements, while nearly 50% of citizen scientists participated only one time. We compared the flood risk-related data obtained from citizen scientists with other independent data sources and found that the agreement between the two datasets on flooding points, land use classification, and the flood damage rate to paddy fields was acceptable (overall agreement above 73%). Rainfall monitoring activities encouraged the participants to proactively update data on flood events and land use situations during the data collection campaign. The study’s outcomes demonstrate that citizen science can help to fill the gap in flood data in data-scarce areas.
Urban expansion in Greater Irbid Municipality, Jordan: the spatial patterns and the driving factors
Authors: Awawdeh Muheeb M. , Abuhadba Rudyna R. , Jamhawi Monther M. , Rawashdeh Ayman I. , Jawarneh Rana N. , Awawdeh Mohsen M. 
Published: February 2024

AbstractUrban expansion within Greater Irbid Municipality (GIM) witnessed an extraordinary rise, expanding approximately ninefold between 1967 and 2020. Recent trends revealed a shift in urban growth towards southern and eastern regions. These dynamics carry critical implications for urban planners and environmental managers, urging a comprehensive understanding of the driving factors behind this expansion to anticipate future challenges. Employing logistic regression (LR) and geographically weighted logistic regression (GWLR) analyses using remote sensing data and GIS, spatially variant coefficients for driving factors emerged, illuminating the evolving landscape of urban development drivers within GIM. Yarmouk University historically promoted urban expansion, but recent proximity to Yarmouk University and JUST University, coupled with higher existing building percentages, inhibited further urbanization. The analysis also revealed that elevation and slope had negligible impacts on urban expansion. These findings underline the evolving dynamics of urban development drivers within the study region. The local perspective depicted significant spatial disparities in coefficients, highlighting variations in magnitude and direction. GWLR emerged as a more robust methodology, effectively capturing regional variations and enhancing model reliability. These findings hold immense value for informing current and future urban planning practices in Greater Irbid Municipality. Proactively addressing identified challenges and understanding the intricate dynamics of urban expansion can assist Irbid in shaping a sustainable and resilient future, avoiding potential pitfalls in its urban development endeavors.
Archaeological Insights into Asymmetrical Warfare on the Queensland Frontier
Authors: Pagels Anthony , Burke Heather , Wallis Lynley A. 
Published: February 2024

AbstractHistoriographic debate in Australia over whether or not the asymmetrical conflicts between Indigenous and non-Indigenous peoples in the colonial period can be characterized as “war” remains unresolved, largely because most such events did not involve the traditional military. In this regard the situation in Queensland merits special attention, since much of the conflict in that colony from 1848 onward was conducted by a particular government paramilitary organization: the Queensland Native Mounted Police (NMP). In trying to understand the operations of this force, we adopt KOCOA terrain analysis, coupled with the forensic analysis of firing pin impressions on discharged Snider cartridge primers, to visualize how features around NMP camps affected and contributed to the use of firearms within these spaces. Given the well-recognized nexus between tactics of hunting and warfare, we argue that it is through the lens of training (both as hunters and soldiers) that we can best understand the Indigenous troopers of the NMP, as well as the strategies and tactics applied by the Queensland NMP in the context of the asymmetrical violence that characterized the Australian frontier.
Evaluation of the (Baha) technique of scleral indentation using a self-retained scleral indenter during vitrectomy surgery: a randomized trial
Authors: El Baha Samir , Ghandour Moutaz , Ahmed Islam S. H. 
Published: February 2024

Abstract
Aims
The current study compared a novel technique of scleral indentation using the self-retaining Leyla retractor to the conventional scleral self-indentation with the chandelier light.

Methods
Patients with rhegmatogenous retinal detachment were randomized on a 1:1 basis to either have the (Baha) indentation using a tip of a thimble scleral indenter welded to the support for the Leyla retractor system or to have the conventional scleral indentation while using a 25-gauge chandelier light. A video was recorded for the surgery of all the cases and reviewed by another consultant masked to the type of indentation. The indentation duration (i.e., the time in seconds between the first appearance of a hump due to scleral indentation in the recorded video until its final disappearance) was measured for every case.

Results
The current study included 60 eyes of 60 adults with a mean age of 59.6 ± 9.8 years. Thirty-nine of the eyes were phakic and 21 were pseudophakic. The mean indentation time was 618 ± 87 and 696 ± 72 s in (Baha) indentation and conventional indentation groups, respectively. The difference was not statistically significant (p = 38). There was a positive correlation between the vertical palpebral fissure height and the indentation duration for both (Baha) indentation (r = 0.58) and conventional indentation groups (r = 0.42). Readjustment of the chandelier endo-illumination was required in 19 cases (63.3%) in the conventional indentation group. Iatrogenic breaks or accidental crystalline lens touch did not occur in any case.

Conclusion
The (Baha) technique is effective and safe, especially in patients with a larger palpebral fissure.