bluuebunny/crossref_metadata_2025_split huggingface dataset:
Assessment of thermal index compliance in clinical ultrasound examinations
Authors: Butler Sam , Ashcroft Kerry , Arrowsmith Sarah , Griffiths Rachel , Studd Adam 
Published: February 2024

Introduction: The thermal index (TI) is critical for monitoring potential heating risks in ultrasound examinations. This study aims to analyse adherence to TI guidelines in clinical ultrasound exams, focusing on the thermal index for soft tissue (TIS) and thermal index for bone at the focus (TIB). Methods: Clinical ultrasound images over a five working day period from a single NHS University Hospital Trust were analysed using a custom MATLAB script. TI values were extracted from DICOM headers, supplemented by optical character recognition for missing values. Time at each TI value (image interval) was measured assuming a constant TI between consecutive images. TI values and corresponding image intervals were compared to TI guidelines provided by the British Medical Ultrasound Society (BMUS). Results: Analysis included 627 obstetric and 1023 non-obstetric examinations, comprising 4643 obstetric and 19,228 non-obstetric image intervals. TIS values across all examinations and image intervals adhered to recommended BMUS limits; however, breaches of the guidelines were observed for TIB. In obstetrics, 44 image intervals across 47 examinations exceeded the TIB limits (1.01% of TIB image intervals and 7.02% of examinations). For non-obstetrics, two image intervals across two examinations exceeded the TIB limits (0.02% of intervals and 0.44% of examinations). Conclusion: The majority of ultrasound examinations considered for this analysis demonstrated compliance with BMUS guidelines for TI, except for a small fraction which showed breaches in the obstetric thermal index for bone at the focus limits. All breaches were associated with the use of pulsed-wave Doppler.
Wellness Programs, Perceived Organizational Support, and Their Influence on Organizational Performance: An Analysis Within the Framework of Sustainable Human Resource Management
Authors: Peña Isidro , Andrade Silvia María , María Muñoz Rosa , Barba-Sánchez Virginia 
Published: February 2024

The wellbeing of employee has become a challenge associated with working towards sustainable human resource management. This study, therefore, focuses on analyzing the role played by companies’ wellness practices as an important part of the social dimension of the “triple bottom line.” We hypothesize that these practices are linked to the employees’ perceived organizational support, and, simultaneously, to organizational performance, in addition to observing the mediating effects of job satisfaction and commitment. We tested the hypotheses by developing a questionnaire. The direct and mediating effects were analyzed using the Partial Least Square (PLS) structural equation technique. The results eventually obtained from 137 questionnaires provided evidence that wellness programs and perceived organizational support influence organizational performance, with mediating effects on job satisfaction and commitment. JEL Classification: L84, M12, M14
Association of Remaining Anterior Knee Laxity With Inferior Outcomes After Revision ACL Reconstruction
Authors: Eggeling Lena , Drenck Tobias Claus , Breer Stephan , Frosch Karl-Heinz , Akoto Ralph 
Published: February 2024

Background: The relationship between remaining anterior knee laxity and poorer clinical outcomes after anterior cruciate ligament reconstruction (ACLR) may be underrated, and the criteria for failure of revision ACLR have not been defined. Purpose/Hypothesis: To evaluate a possible association between remaining knee laxity and functional scores in patients after revision ACLR. We hypothesized that a postoperative side-to-side-difference (SSD) in knee laxity of ≥6 mm will be an objective parameter for failure. Study Design: Cohort study; Level of evidence, 3. Methods: A total of 200 patients (77 women and 123 men; mean age, 30.8 ± 11 years; range, 18-61 years) who underwent revision ACLR between 2016 and 2019 were evaluated; The mean follow-up period was 30.2 ± 9 months (range, 24-67 months). Patients were divided into 3 groups according to postoperative SSD (<3 mm, 3-5 mm, or ≥6 mm). Preoperative and postoperative outcome measures (Lachman, pivot shift, visual analog scale [VAS] for pain, Tegner, Lysholm, International Knee Documentation Committee, and Knee injury and Osteoarthritis Outcome Score) were compared between the groups. Results: Of the 200 patients, 74% (n = 148) had a postoperative SSD of <3 mm at the latest follow-up, 19.5% (n = 39) had a postoperative SSD of 3 to 5 mm, and 6.5% (n = 13) had a postoperative SSD of ≥6 mm. Patients in all groups saw significant pre- to postoperative reductions in positive Lachman and pivot-shift tests as well as significant improvements in VAS pain, Lysholm, and Tegner scores ( P < .001 for all). All postoperative functional scores of the patients with SSDs of <3 mm and 3-5 mm were significantly increased compared with those of patients with an SSD of ≥6 mm ( P≤ .01 for all). Conclusion: In patients following revision ACLR, anterior and rotational knee laxity were successfully reduced while increasing postoperative functional outcomes. A remaining postoperative SSD of ≥6 mm was associated with inferior patient outcomes compared with an SSD <6 mm. An SSD of ≥6 mm represents an objective parameter in the definition of failure of revision ACLR.
Decreased Effective Patellar Tendon Length following Distalization Tibial Tubercle Osteotomy without Patellar Tendon Tenodesis
Authors: Uppstrom Tyler J. , Fletcher Connor F. , Green Daniel W. , Gomoll Andreas H. , Strickland Sabrina M. 
Published: February 2024

Background: Distalization tibial tubercle osteotomy (TTO) is an effective treatment for improving patellar height in patients with patella alta associated with patellofemoral instability and cartilage lesions. The addition of a patellar tendon tenodesis has been suggested; nonetheless, concerns exist regarding possible increased patellofemoral cartilage stresses. Purpose: To evaluate pre- and postoperative patellar tendon length and alignment parameters on magnetic resonance imaging (MRI), as well as patient-reported outcome measures (PROMs) after distalization TTO without patellar tendon tenodesis. Study Design: Case series; Level of evidence, 4. Methods: Twenty skeletally mature patients who underwent distalization TTO with or without anteromedialization at our institution between December 2014 and August 2021 were included. All patients underwent pre- and postoperative MRIs of the affected knee. The Caton-Deschamps index (CDI), the axial and sagittal tibial tubercle–trochlear groove (TT-TG) distances, the distances from the tibial plateau to the patellar tendon insertion and the tibial tubercle, and the patellar tendon length were assessed. PROMs included the International Knee Documentation Committee Subjective Knee Evaluation Form, the Knee injury and Osteoarthritis Outcome Score–Quality of Life subscale, the Kujala Anterior Knee Pain Scale, and the Veterans RAND 12-Item Health Survey mental and physical component scores. Results: The mean patient age at surgery was 27.4 years (range, 14-42 years). Radiographic parameters demonstrated improved patellar height (CDI decreased from 1.36 to 1.11; P < .001) after distalization TTO. The distance from the tibial plateau to the patellar tendon insertion significantly decreased from 20.1 mm preoperatively to 17.9 mm postoperatively ( P < .020), and the patellar tendon length decreased from 53.4 mm preoperatively to 46.0 mm postoperatively ( P < .001). The patellar tendon insertion was not distalized after distalization TTO, likely because of scarring of the patellar tendon proximal to the osteotomy site. Patients demonstrated significant pre- to postoperative improvements on all PROMs ( P≤ .024 for all ). There were 4 (20%) complications—2 cases of arthrofibrosis, 1 postoperative infection, and 1 osteotomy delayed union. Conclusion: Distalization TTO without patellar tendon tenodesis was associated with improved radiographic outcomes and PROMs. It provides an additional tool for surgical management of patellofemoral pathology with associated patella alta.
Utilizing bio-synthesis of nanomaterials as biological agents for controlling soil-borne diseases in pepper plants: root-knot nematodes and root rot fungus
Authors: Y. Ghareeb Rehab , Belal Elsayed B. , El-Khateeb Nagwa M. M. , Shreef Basma A. 
Published: February 2024

AbstractThe utilization ofTrichoderma longibrachiatumfiltrate as a safe biocontrol method for producing zinc nanoparticles is a promising approach for managing pests and diseases in agricultural crops. The identification ofTrichodermasp. was achieved through PCR amplification and sequencing of 18s as ON203115, while the synthesis of ZnO-NPs was accomplished by employing Trichoderma filtration. The presence of ZnO-NPs was confirmed by observing a color change to dark green, along with the use of visible and UV spectrophotometers, and the formation and chemical structure of ZnO-NPs were examined. Direct exposure to ZnO-NPs exhibited a significant inhibitory effect on the growth ofFusarium oxysporumat 80.73% compared with control. Also, the percent mortality ofMeloidogyne incognitasecond juveniles stage (J2s) results showed 11.82%, 37.63%, 40.86%, and 89.65% after 6, 12, 24, and 72 h, respectively in vitro. Disease resistance was assessed in the greenhouse againstM. incognitaandF. oxysporumusing the drench application of ZnO-NPs. The application of ZnO-NPs significantly reduced the disease severity ofF. oxysporumand improved the quality and quantity of sweet pepper yield. In addition, the application of ZnO-NPs toM. incognitaresulted in a significant reduction in the number of nematode galls, egg masses per root, eggs/egg mass, and females by 98%, 99%, 99.9%, and 95.5% respectively.Furthermore, it was observed that the application of ZnO-NPs to pepper plants not only inhibited the growth ofF. oxysporumandM. incognita, but also promoted the recovery of pepper plants as indicated by improvements in stem length by 106%, root length 102%, fresh weight 112%, root fresh weight 107%, and leaf area 118% compared to healthy control plants. Additionally, real-time PCR application and DD-PCR technique revealed that the application of ZnO-NPs stimulated the secretion of certain enzymes. These findings suggest that the biosynthesized ZnO-NPs possess anti-nematode and antifungal properties, making them effective for protecting plants againstM. incognitaandF. oxysporuminvasion in soil. This study significantly contributes to our understanding of the nematicidal and fungicidal activities of ZnO-NPs in suppressing soil-borne diseases.
Development and inter-rater reliability of a simple prehospital mobility score for use in emergency patients
Authors: Asmussen Søren Westh , Holme Jacob Metze , Joensen Kurt , Ibsen Stine , Bøggild Henrik , Christensen Erika Frischknecht , Lindskou Tim Alex 
Published: February 2024

Abstract
Background
Mobility assessment enhances the ability of vital sign-based early warning scores to predict risk. Currently mobility is not routinely assessed in a standardized manner in Denmark during the ambulance transfer of unselected emergency patients. The aim of this study was to develop and test the inter-rater reliability of a simple prehospital mobility score for pre-hospital use in ambulances and to test its inter-rater reliability.

Method
Following a pilot study, we developed a 4-level prehospital mobility score based of the question”How much help did the patient need to be mobilized to the ambulance trolley”. Possible scores were no-, a little-, moderate-, and a lot of help. A cross-sectional study of inter-rater agreement among ambulance personnel was then carried out. Paramedics on ambulance runs in the North- and Central Denmark Region, as well as The Fareoe Islands, were included as a convenience sample between July 2020—May 2021. The simple prehospital mobility score was tested, both by the paramedics in the ambulance and by an additional observer. The study outcomes were inter-rater agreements by weighted kappa between the paramedics and between observers and paramedics.

Results
We included 251 mobility assessments where the patient mobility was scored. Paramedics agreed on the mobility score for 202 patients (80,5%). For 47 (18.7%), there was a deviation of one between scores, in two (< 1%) there was a deviation of two and none had a deviation of three (Table 1).

Inter-rater agreement between paramedics in all three regions showed a kappa-coefficient of 0.84 (CI 95%: 0.79;0.88). Between observers and paramedics in North Denmark Region and Faroe Islands the kappa-coefficient was 0.82 (CI 95%: 0.77;0.86).

Conclusion
We developed a simple prehospital mobility score, which was feasible in a prehospital setting and with a high inter-rater agreement between paramedics and observers.
The association of painful and non-painful morbidities with frailty: a cross sectional analysis of a cohort of community dwelling older people in England
Authors: Chaplin W. J. , Lewis H. R. , Shahtaheri S. M. , Millar B. S. , McWilliams D. F. , Gladman J. R. F. , Walsh D. A. 
Published: February 2024

Abstract
Introduction
The association between chronic pain and frailty might indicate that pain is an independent driver of frailty but might alternatively be explained by inclusion within frailty identification tools of morbidities that commonly lead to chronic pain. This research examines the extent to which the association of pain with frailty might be attributed to morbidities.

Methods
A cross-sectional analysis of older people in a UK cohort with or at risk of musculoskeletal problems or frailty (Investigating Musculoskeletal Health and Wellbeing study), used multivariable logistic regression and Z-tests to assess the degrees of associations of pain (McGill Pain Rating Index), and painful and non-painful morbidity counts with frailty (modified FRAIL questionnaire).

Results
Data were from 2,185 participants, 56% female, median age 73 (range 60 to 96) years. 430 (20%) participants were classified as frail. In a fully adjusted standardised model, pain (aOR 2.07 (95%CI 1.83 to 2.33) and ‘any’ morbidity aOR (1.74 (95%CI 1.54 to 1.97) were both significantly associated with frailty. When morbidity was subclassified as painful or non-painful, painful (aOR 1.48 (95%CI 1.30 to 1.68) and non-painful (aOR1.39 (95%CI 1.24 to 1.56)) morbidities each were associated with frailty, as also was pain (aOR 2.07 (95%CI 1.83 to 2.34, p < 0.001).

Conclusions
Pain is associated with frailty, over and above any effect of painful and non-painful morbidities. This forms the justification for future research which focuses on pain management in the identification, prevention, and treatment of frailty.
Repeated hospital admission for intentional poisonings among older adults - a Swedish national register-based study
Authors: Laflamme L , Lindholm E , Möller Jette 
Published: February 2024

Abstract
Background
Poisoning injuries is an increasing concern among older people, and so is the repetition of intentional poisonings. To date, few studies have documented the pattern and individual risk factors for repeated poisonings. This national study aims to shed light on the burden, pattern, and health-related risk factors of repeated intentional poisoning leading to hospitalization or death among older Swedish adults (50 years and older), with a focus on the year following a first event.

Methods
We conducted a nationwide register-based cohort study of people aged 50–100, hospitalized for intentional poisoning (ICD10: X60-69) during 2006–2016 (n = 15,219) and re-hospitalized by poisoning of any intent within a year (n = 1710), i.e., up to the end of 2017. We considered in turn, the distribution of the second poisoning in 30-day intervals stratified by intent; poisoning lethality within a month and a year; and the sex-specific association between health conditions and being re-hospitalized for intentional poisoning within one year as compared to being hospitalized only once using logistic regression (odds ratios (OR) with 95% confidence intervals (95% CI)).

Results
Following an intentional poisoning, re-hospitalization within a year was predominantly for a new intentional poisoning (89.7%) and occurred most typically within a month (median 4 days). Death within 30 days occurred in similar proportion for the first and second poisoning (2.3% vs. 2.1% respectively). Among both men and women, comorbidity of psychiatric illness was strongly associated with re-hospitalization for intentional poisoning (adjusted ORs = 1.70; 95% CI = 1.45–2.01 and 1.89 (95% CI = 1.60–2.19) respectively).

Conclusion
Most re-hospitalizations within a year after intentional poisoning are also for intentional poisoning and occur most typically within days. Re-hospitalization is associated with several conditions that are characteristic of poor mental health and there are more similarities than differences between men and women in that respect.
Increased serum methylmalonic acid levels were associated with the presence of cognitive dysfunction in older chronic kidney disease patients with albuminuria
Authors: Zhang Jialing , Wu Leiyun , Wang Shiyuan , Pan Yajing , Zhang Aihua 
Published: February 2024

Abstract
Background
This study aimed to evaluate the correlation between serum methylmalonic acid (MMA) levels and cognition function in patients with chronic kidney disease (CKD).

Methods
In this cross-sectional study, we included 537 CKD individuals aged ≥ 60-year-old with albuminuria from the National Health and Nutrition Examination Survey (NHANES) 2011–2014. Four cognitive tests including the Digit Symbol Substitution Test (DSST), the Consortium to Establish a Registry for Alzheimer’s Disease (CERAD) Delayed Recall and Word Learning tests, and the Animal Fluency test (AF) were performed. Associations between MMA and cognition scores were assessed with linear regression models.

Results
MMA level was negatively associated with residual renal function and nutrition status. After multivariate adjustment, elevated serum MMA levels were independently correlated with decline of cognition in CKD patients with albuminuria.

Conclusion
Our study showed that higher serum MMA levels were independently associated with the presence of cognition dysfunction in CKD patients. The exact pathogenesis of MMA and cognition needs further research.
Retrospective study about clinical severity and epidemiological analysis of the COVID-19 Omicron subvariant lineage-infected patients in Hohhot, China
Authors: Wang Yanhai , Yu Guohui , Shi Jingru , Zhang Xiaqing , Huo Jianxin , Li Meng , Chen Jiaxi , Yu Liyuan , Li Yan , Han Zhiliang , Zhang Jianwen , Ren Xuna , Wang Yujie , Yuntana Wu 
Published: February 2024

Abstract
Background
Fear of a global public health issue and fresh infection wave in the persistent COVID-19 pandemic has been enflamed by the appearance of the novel variant Omicron BF.7 lineage. Recently, it has been seeing the novel Omicron subtype BF.7 lineage has sprawled exponentially in Hohhot. More than anything, risk stratification is significant to ascertain patients infected with COVID-19 who the most need in-hospital or in-home management. The study intends to understand the clinical severity and epidemiological characteristics of COVID-19 Omicron subvariant BF.7. lineage via gathering and analyzing the cases with Omicron subvariant in Hohhot, Inner Mongolia.

Methods
Based upon this, we linked variant Omicron BF.7 individual-level information including sex, age, symptom, underlying conditions and vaccination record. Further, we divided the cases into various groups and assessed the severity of patients according to the symptoms of patients with COVID-19. Clinical indicators and data might help to predict disadvantage outcomes and progression among Omicron BF.7 patients.

Results
In this study, in patients with severe symptoms, some indicators from real world data such as white blood cells, AST, ALT and CRE in patients with Omicron BF.7 in severe symptoms were significantly higher than mild and asymptomatic patients, while some indicators were significantly lower.

Conclusions
Above results suggested that the indicators were associated with ponderance of clinical symptoms. Our survey emphasized the value of timely investigations of clinical data obtained by systemic study to acquire detailed information.
CT radiomics-based model for predicting TMB and immunotherapy response in non-small cell lung cancer
Authors: Wang Jiexiao , Wang Jialiang , Huang Xiang , Zhou Yanfei , Qi Jian , Sun Xiaojun , Nie Jinfu , Hu Zongtao , Wang Shujie , Hong Bo , Wang Hongzhi 
Published: February 2024

Abstract
Background
Tumor mutational burden (TMB) is one of the most significant predictive biomarkers of immunotherapy efficacy in non-small cell lung cancer (NSCLC). Radiomics allows high-throughput extraction and analysis of advanced and quantitative medical imaging features. This study develops and validates a radiomic model for predicting TMB level and the response to immunotherapy based on CT features in NSCLC.

Method
Pre-operative chest CT images of 127 patients with NSCLC were retrospectively studied. The 3D-Slicer software was used to outline the region of interest and extract features from the CT images. Radiomics prediction model was constructed by LASSO and multiple logistic regression in a training dataset. The model was validated by receiver operating characteristic (ROC) curves and calibration curves using external datasets. Decision curve analysis was used to assess the value of the model for clinical application.

Results
A total of 1037 radiomic features were extracted from the CT images of NSCLC patients from TCGA. LASSO regression selected three radiomics features (Flatness, Autocorrelation and Minimum), which were associated with TMB level in NSCLC. A TMB prediction model consisting of 3 radiomic features was constructed by multiple logistic regression. The area under the curve (AUC) value in the TCGA training dataset was 0.816 (95% CI: 0.7109–0.9203) for predicting TMB level in NSCLC. The AUC value in external validation dataset I was 0.775 (95% CI: 0.5528–0.9972) for predicting TMB level in NSCLC, and the AUC value in external validation dataset II was 0.762 (95% CI: 0.5669–0.9569) for predicting the efficacy of immunotherapy in NSCLC.

Conclusion
The model based on CT radiomic features helps to achieve cost effective improvement in TMB classification and precise immunotherapy treatment of NSCLC patients.