bluuebunny/crossref_metadata_2025_split huggingface dataset:
Exploring feminist political economy and feminist critical discourse analysis as methodologies in critical nursing research
Authors: Lebold Margaret 
Published: October 2023

AbstractAimsThis paper explores two critical feminist methodologies for nursing research: feminist political economy and feminist critical discourse analysis. The aim was to appreciate varied methodological approaches available for nurses to understand complexities in healthcare environments, above and beyond socially normative ways of knowing.DesignDiscursive paper.Data SourcesPublished articles from nursing databases (CINAHL and ProQuest; no date restrictions) and interdisciplinary databases (Women's Studies International, Sociological Abstracts and Ovid MEDLINE; publication dates between 2017 and 2022).MethodsA discursive paper exploring and critically synthesizing the literature on feminist political economy and feminist critical discourse analysis to demonstrate how each methodological approach can be used in nursing.ResultsThe findings of this discursive paper suggest there is an opportunity to draw on interdisciplinary studies for creative insights into how these methodologies may be helpful for nurses' scholarship and programmes of research. Although few nursing studies explicitly name a feminist political economy or feminist critical discourse analysis approach, several studies apply principles of these methodological approaches.ConclusionThere is an opportunity for these methodologies to be applied within the same project when there is a fit between the research questions and aims of both methodologies (studies where notions of gender and power are considered central and there are potential insights from exploring social progress, structures and the material, along with the social relations of discourses).Implications for the Profession and/or Patient CareFeminist political economy and feminist critical discourse analysis offer novel options for methodological analyses.ImpactApplication of these methodologies may benefit critical nursing scholars looking for diverse critical methodological avenues to explore and to broaden nursing's methodological toolbox towards meeting social justice aims.Patient or Public ContributionNo patient or public contribution.
Genomic prediction and genome‐wide association studies for additive and dominance effects for body composition traits using 50 K and imputed high‐density SNP genotypes in Yunong‐black pigs
Authors: Wu Ziyi , Dou Tengfei , Bai Liyao , Han Jinyi , Yang Feng , Wang Kejun , Han Xuelei , Qiao Ruimin , Li Xiu‐Ling , Li Xin‐Jian 
Published: October 2023

AbstractBody composition traits are complex traits controlled by minor genes and, in hybrid populations, are impacted by additive and nonadditive effects. We aimed to identify candidate genes and increase the accuracy of genomic prediction of body composition traits in crossbred pigs by including dominance genetic effects. Genomic selection (GS) and genome‐wide association studies were performed on seven body composition traits in 807 Yunong‐black pigs using additive genomic models (AM) and additive‐dominance genomic models (ADM) with an imputed high‐density single nucleotide polymorphism (SNP) array and the Illumina Porcine SNP50 BeadChip. The results revealed that the additive heritabilities estimated for AM and ADM using the 50 K SNP data ranged from 0.20 to 0.34 and 0.11 to 0.30, respectively. However, the ranges of additive heritability for AM and ADM in the imputed data ranged from 0.20 to 0.36 and 0.12 to 0.30, respectively. The dominance variance accounted for 23% and 27% of the total variance for the 50 K and imputed data, respectively. The accuracy of genomic prediction improved by 5% on average for 50 K and imputed data when dominance effect were considered. Without the dominance effect, the accuracies for 50 K and imputed data were 0.35 and 0.38, respectively, and 0.41 and 0.43, respectively, upon considering it. A total of 12 significant SNP and 16 genomic regions were identified in the AM, and 14 significant SNP and 21 genomic regions were identified in the ADM for both the 50 K and imputed data. There were five overlapping SNP in the 50 K and imputed data. In the AM, a significant SNP (CNC10041568) was found in both body length and backfat thickness traits, which was in the PLAG1 gene strongly and significantly associated with body length and backfat thickness in pigs. Moreover, a significant SNP (CNC10031356) with a heterozygous dominant genotype was present in the ADM. Furthermore, several functionally related genes were associated with body composition traits, including MOS, RPS20, LYN, TGS1, TMEM68, XKR4, SEMA4D and ARNT2. These findings provide insights into molecular markers and GS breeding for the Yunong‐black pigs.
Are MOOC learning designs culturally inclusive (enough)?
Authors: Rizvi Saman , Rienties Bart , Rogaten Jekaterina , Kizilcec René F. 
Published: October 2023

AbstractBackgroundExtensive research on massive open online courses (MOOCs) has focused on analysing learners' behavioural trace data to understand navigation and activity patterns, which are known to vary systematically across geo‐cultural contexts. However, the perception of learners regarding the role of different learning design elements in sustaining their engagement in the course is still unclear.ObjectivesThis study aimed to examine learners' perception of learning design elements in MOOCs and explore the ways in which these perceptions differ between geo‐cultural contexts.MethodsWe conducted interviews with 22 learners from seven geo‐cultural regions to gather insights into their learning design preferences.ResultsOur findings indicate that learners from regions such as South Asia exhibit a strong inclination towards video‐based content and a lesser preference for reading textual resources. In contrast, learners from regions such as Anglo‐Saxon demonstrate a high preference for reading texts such as articles and video transcripts.ConclusionThe observed variations in self‐reported interests in various learning design elements raise intriguing questions about the nature and extent of participation of various geo‐cultural groups. This study underscores the need to develop inclusive MOOC designs and implement learning analytics approaches that adapt to the cultural preferences of learners.
Periodontitis in young individuals: Important factors for disease progression
Authors: Modin Carolina , Rinon Caroline Dolk , Faham Ali , Gustafsson Anders , Yucel‐Lindberg Tülay , Jansson Leif 
Published: October 2023

AbstractAimTo investigate the progression of periodontitis in young individuals and identify factors that contribute to progression rate and whether periodontitis stage and grade have an impact on disease progression.Materials and MethodsThis retrospective cohort study was based on patients younger than 36 years at two periodontal clinics between 2003 and 2009. At least 10 years later, a clinical and radiographic examination was performed on 215 patients. The marginal bone loss between baseline and follow‐up for the tooth with the most severe bone loss at follow‐up was estimated by radiographic measurements. Linear regression analysis was used to investigate the influence of potential risk indicators on periodontitis progression.ResultsMost patients (83%) were classified as periodontitis stage III at baseline. At follow‐up, 70% of these patients remained in stage III. The frequency of patients with grade C decreased from 79% to 17% at follow‐up. The median (Q25%; Q75%) of the longitudinal marginal bone loss was 0.5 mm (0.0; 2.0). High bleeding on probing (BOP) index at baseline, smoking and interruption of periodontal treatment were found to significantly increase longitudinal bone loss.ConclusionsHigh levels of BOP at baseline, smoking and interruption of periodontal treatment increased the risk of marginal bone loss. The stage and grade at baseline had no significant impact on disease progression.
Research Review: Child emotion regulation mediates the association between family factors and internalizing symptoms in children and adolescents – a meta‐analysis
Authors: Lin Sylvia Chu , Kehoe Christiane , Pozzi Elena , Liontos Daniel , Whittle Sarah 
Published: October 2023

BackgroundParental influence on children's internalizing symptoms has been well established; however, little is known about the underlying mechanisms. One possible mechanism is child emotion regulation given evidence (a) of its associations with internalizing symptoms and (b) that the development of emotion regulation during childhood and adolescence is influenced by aspects of the family environment. This meta‐analysis aimed to systematically investigate the mediating role of child emotion regulation in the relationship between various family factors and internalizing symptoms in children and adolescents.MethodsWe searched Medline, Embase, PsychInfo, and Web of Science for English articles up until November 2022. We included studies that examined child emotion regulation as a mediator between a family factor and child/adolescent internalizing symptoms. Random‐effects models were used to calculate pooled indirect effects and total effects for nine family factors. Heterogeneity and mediation ratio were also calculated.ResultsOf 49 studies with 24,524 participants in this meta‐analysis, family factors for which emotion regulation mediated the association with child/adolescent internalizing symptoms included: unsupportive emotion socialization, psychological control, secure attachment, aversiveness, family conflict, parent emotion regulation and parent psychopathology, but not supportive emotion socialization and behavioral control.ConclusionsVarious family factors impact children's emotion regulation development, and in turn, contribute to the risk of internalizing symptoms in young people. Findings from this study highlight the need for interventions targeting modifiable parenting behaviors to promote healthy emotion regulation and better mental health in children and adolescents.
Subtyping at‐risk adolescents for predicting response toward insomnia prevention program
Authors: Chen Si‐Jing , Li Shirley Xin , Zhang Jihui , Lam Siu Ping , Chan Joey Wing Yan , Chan Kate Ching‐Ching , Li Albert Martin , Morin Charles M. , Wing Yun Kwok , Chan Ngan Yin 
Published: October 2023

BackgroundPrevious study has shown that a brief cognitive‐behavioral prevention insomnia program could reduce 71% risk of developing insomnia among at‐risk adolescents. This study aimed to evaluate the differential response to insomnia prevention in subgroups of at‐risk adolescents.MethodsAdolescents with a family history of insomnia and subthreshold insomnia symptoms were randomly assigned to a 4‐week insomnia prevention program or nonactive control group. Assessments were conducted at baseline, 1 week, and 6‐ and 12‐month after the intervention. Baseline sleep, daytime, and mood profiles were used to determine different subgroups by using latent class analysis (LCA). Analyses were conducted based on the intention‐to‐treat approach.ResultsLCA identified three subgroups: (a) insomnia symptoms only, (b) insomnia symptoms with daytime sleepiness and mild anxiety, and (c) insomnia symptoms with daytime sleepiness, mild anxiety, and depression. The incidence rate of insomnia disorder over the 12‐month follow‐up was significantly reduced for adolescents receiving intervention in subgroup 3 compared with the controls (hazard ratio [HR] = 0.37; 95% confidence interval [CI]: 0.13–0.99; p = .049) and marginally for subgroup 2 (HR = 0.14; 95% CI: 0.02–1.08; p = .059). In addition, adolescents who received intervention in subgroups 2 and 3 had a reduced risk of excessive daytime sleepiness (subgroup 2: adjusted OR [AdjOR] = 0.45, 95% CI: 0.23–0.87; subgroup 3: AdjOR = 0.32, 95% CI: 0.13–0.76) and possible anxiety (subgroup 2: AdjOR = 0.47, 95% CI: 0.27–0.82; subgroup 3: AdjOR = 0.33, 95% CI: 0.14–0.78) compared with the controls over the 12‐month follow‐up.ConclusionsAdolescents at risk for insomnia can be classified into different subgroups according to their psychological profiles, which were associated with differential responses to the insomnia prevention program. These findings indicate the need for further phenotyping and subgrouping at‐risk adolescents to develop personalized insomnia prevention.
High sensitivity C‐reactive protein and prediabetes progression and regression in middle‐aged and older adults: A prospective cohort study
Authors: Cheng Zi‐Jian , Wang Yan‐Fei , Jiang Xi‐Yuan , Ren Wen‐Yan , Lei Shu‐Feng , Deng Fei‐Yan , Wu Long‐Fei 
Published: October 2023

ABSTRACTBackgroundThis study aimed to investigate the effect of systemic inflammation, assessed by high sensitivity C‐reactive protein (hs‐CRP) levels, on prediabetes progression and regression in middle‐aged and older adults based on the China Health and Retirement Longitudinal Study (CHARLS).MethodsParticipants with prediabetes from CHARLS were followed up 4 years later with blood samples collected for measuring fasting plasma glucose (FPG) and hemoglobin A1c (HbA1c). The level of hs‐CRP was assessed at baseline and categorized into tertiles (low, middle, and high groups). Prediabetes at baseline and follow‐up was defined primarily according to the American Diabetes Association (ADA) criteria. Logistic regression models were used to estimate the odds ratios (ORs) and confidence intervals (CIs). We also performed stratified analyses according to age, gender, BMI, the presence of hypertension, and the disease history of heart disease and dyslipidemia and sensitivity analyses excluding a subset of participants with incomplete data.ResultsOf the 2,874 prediabetes included at baseline, 834 participants remained as having prediabetes, 146 progressed to diabetes, and 1,894 regressed to normoglycemia based on ADA criteria with a 4 year follow‐up. After multivariate logistics regression analysis, prediabetes with middle (0.67–1.62 mg/L) and high (>1.62 mg/L) hs‐CRP levels had an increased incidence of progressing to diabetes compared with prediabetes with low hs‐CRP levels (<0.67 mg/L; OR = 1.846, 95%CI: 1.129–3.018; and OR = 1.632, 95%CI: 0.985–2.703, respectively), and the incidence of regressing to normoglycemia decreased (OR = 0.793, 95%CI: 0.645–0.975; and OR = 0.769, 95%CI: 0.623–0.978, respectively). Stratified analyses and sensitivity analyses showed consistent results.ConclusionsLow levels of hs‐CRP are associated with a high incidence of regression from prediabetes to normoglycemia and reduced odds of progression to diabetes.
Kaonashia insperata gen. et sp. nov., a eukaryotrophic flagellate, represents a novel major lineage of heterotrophic stramenopiles
Authors: Weston Elizabeth J. , Eglit Yana , Simpson Alastair G. B. 
Published: October 2023

AbstractEukaryotrophic protists are ecologically significant and possess characteristics key to understanding the evolution of eukaryotes; however, they remain poorly studied, due partly to the complexities of maintaining predator–prey cultures. Kaonashia insperata, gen. nov., et sp. nov., is a free‐swimming biflagellated eukaryotroph with a conspicuous ventral groove, a trait observed in distantly related lineages across eukaryote diversity. Di‐eukaryotic (predator–prey) cultures of K. insperata with three marine algae (Isochrysis galbana, Guillardia theta, and Phaeodactylum tricornutum) were established by single‐cell isolation. Growth trials showed that the studied K. insperata clone grew particularly well on G. theta, reaching a peak abundance of 1.0 × 105 ± 4.0 × 104 cells ml−1. Small‐subunit ribosomal DNA phylogenies infer that K. insperata is a stramenopile with moderate support; however, it does not fall within any well‐defined phylogenetic group, including environmental sequence clades (e.g. MASTs), and its specific placement remains unresolved. Electron microscopy shows traits consistent with stramenopile affinity, including mastigonemes on the anterior flagellum and tubular mitochondrial cristae. Kaonashia insperata may represent a novel major lineage within stramenopiles, and be important for understanding the evolutionary history of the group. While heterotrophic stramenopile flagellates are considered to be predominantly bacterivorous, eukaryotrophy may be relatively widespread amongst this assemblage.
Intersectional blackness matters: Why family science should care about the College Board's A.P. African American Studies course controversy
Authors: Banks Ingrid 
Published: October 2023

AbstractThis article examines how the recent controversy about the College Board's A.P. African American Studies course has implications for studies on Black families. In relegating Black feminism and Black queer theory as optional research topics in the course, the College Board failed to recognize the importance of theorizing intersectional blackness in research in Black Studies in general and research on Black families in particular. The College Board failed to recognize how race, gender, sexuality, and other social forces converge to provide a richer picture of Black lives. In utilizing a theoretical lens of intersectional blackness as a foundation, I use both the Florida Board of Education's position regarding the “merits” of the A.P. course and the College Board's decision to fringe certain topics as examples of how both Black families and Black Studies are maligned by framing both as inferior and lacking.
Successful aging after elective surgery II: Study cohort description
Authors: Ward Michelle , Hshieh Tammy T. , Schmitt Eva M. , Arnold Steven E. , Cavallari Michele , Dickerson Bradford C. , Dillon Simon T. , Fong Tamara G. , Jones Richard N. , Libermann Towia A. , Pascual‐Leone Alvaro , Shafi Mouhsin M. , Touroutoglou Alexandra , Weng Karen , Xu Guoquan , Earp Brandon E. , Kunze Lisa , Lange Jeffrey , Vlassakov Kamen , Marcantonio Edward R. , Inouye Sharon K. , Travison Thomas G. ,   for the SAGES II Study Team
Published: October 2023

AbstractBackgroundThe Successful Aging after Elective Surgery (SAGES) II Study was designed to examine the relationship between delirium and Alzheimer's disease and related dementias (AD/ADRD), by capturing novel fluid biomarkers, neuroimaging markers, and neurophysiological measurements. The goal of this paper is to provide the first complete description of the enrolled cohort, which details the baseline characteristics and data completion. We also describe the study modifications necessitated by the COVID‐19 pandemic, and lay the foundation for future work using this cohort.MethodsSAGES II is a prospective observational cohort study of community‐dwelling adults age 65 and older undergoing major non‐cardiac surgery. Participants were assessed preoperatively, throughout hospitalization, and at 1, 2, 6, 12, and 18 months following discharge to assess cognitive and physical functioning. Since participants were enrolled throughout the COVID‐19 pandemic, procedural modifications were designed to reduce missing data and allow for high data quality.ResultsAbout 420 participants were enrolled with a mean (standard deviation) age of 73.4 (5.6) years, including 14% minority participants. Eighty‐eight percent of participants had either total knee or hip replacements; the most common surgery was total knee replacement with 210 participants (50%). Despite the challenges posed by the COVID‐19 pandemic, which required the use of novel procedures such as video assessments, there were minimal missing interviews during hospitalization and up to 1‐month follow‐up; nearly 90% of enrolled participants completed interviews through 6‐month follow‐up.ConclusionWhile there are many longitudinal studies of older adults, this study is unique in measuring health outcomes following surgery, along with risk factors for delirium through the application of novel biomarkers—including fluid (plasma and cerebrospinal fluid), imaging, and electrophysiological markers. This paper is the first to describe the characteristics of this unique cohort and the data collected, enabling future work using this novel and important resource.
Neuroanatomical and cognitive biomarkers of alpha‐synuclein propagation in a mouse model of synucleinopathy prior to onset of motor symptoms
Authors: Tullo Stephanie , Miranda Aline S. , del Cid‐Pellitero Esther , Lim Mei Peng , Gallino Daniel , Attaran Anoosha , Patel Raihaan , Novikov Vladislav , Park Megan , Beraldo Flavio H. , Luo Wen , Shlaifer Irina , Durcan Thomas M. , Bussey Timothy J. , Saksida Lisa M. , Fon Edward A. , Prado Vania F. , Prado Marco A. M. , Chakravarty M. Mallar 
Published: October 2023

AbstractSignificant evidence suggests that misfolded alpha‐synuclein (aSyn), a major component of Lewy bodies, propagates in a prion‐like manner contributing to disease progression in Parkinson's disease (PD) and other synucleinopathies. In fact, timed inoculation of M83 hemizygous mice with recombinant human aSyn preformed fibrils (PFF) has shown symptomatic deficits after substantial spreading of pathogenic alpha‐synuclein, as detected by markers for the phosphorylation of S129 of aSyn. However, whether accumulated toxicity impact human‐relevant cognitive and structural neuroanatomical measures is not fully understood. Here we performed a single unilateral striatal PFF injection in M83 hemizygous mice, and using two assays with translational potential, ex vivo magnetic resonance imaging (MRI) and touchscreen testing, we examined the combined neuroanatomical and behavioral impact of aSyn propagation. In PFF‐injected mice, we observed widespread atrophy in bilateral regions that project to or receive input from the injection site using MRI. We also identified early deficits in reversal learning prior to the emergence of motor symptoms. Our findings highlight a network of regions with related cellular correlates of pathology that follow the progression of aSyn spreading, and that affect brain areas relevant for reversal learning. Our experiments suggest that M83 hemizygous mice injected with human PFF provides a model to understand how misfolded aSyn affects human‐relevant pre‐clinical measures and suggest that these pre‐clinical biomarkers could be used to detect early toxicity of aSyn and provide better translational measures between mice and human disease.image
Emerging roles for ITAM and ITIM receptor signaling in microglial biology and Alzheimer's disease‐related amyloidosis
Authors: Samuels Joshua D. , Lukens John R. , Price Richard J. 
Published: October 2023

AbstractMicroglia are critical responders to amyloid beta (Aβ) plaques in Alzheimer's disease (AD). Therefore, the therapeutic targeting of microglia in AD is of high clinical interest. While previous investigation has focused on the innate immune receptors governing microglial functions in response to Aβ plaques, how microglial innate immune responses are regulated is not well understood. Interestingly, many of these microglial innate immune receptors contain unique cytoplasmic motifs, termed immunoreceptor tyrosine‐based activating and inhibitory motifs (ITAM/ITIM), that are commonly known to regulate immune activation and inhibition in the periphery. In this review, we summarize the diverse functions employed by microglia in response to Aβ plaques and also discuss the innate immune receptors and intracellular signaling players that guide these functions. Specifically, we focus on the role of ITAM and ITIM signaling cascades in regulating microglia innate immune responses. A better understanding of how microglial innate immune responses are regulated in AD may provide novel therapeutic avenues to tune the microglial innate immune response in AD pathology.image