bluuebunny/crossref_metadata_2025_split huggingface dataset:
Efectos de la estimulación temprana en neonatos pre-término. Una revisión sistemática
Authors: Pérez García María Belén , Álvarez Carrión Sonia Alexandra , Vallejo Chinche Silvia del Pilar , Mena Morocho Dominnik Jhair 
Published: January 2024

Introducción. La prematuridad constituye la principal causa de morbimortalidad en niños menores de cinco años, y es el causante del 50% de la discapacidad en niños. Cuando un niño nace antes de las 32 semanas de gestación y con bajo peso, tiene más posibilidades de sufrir una hemorragia interna ventricular (HIV) por la inmadurez de la matriz germinal (MG), pudiendo generar daños en el neurodesarrollo en diferentes aspectos. Objetivo. Identificar los efectos de la estimulación temprana en neonatos prematuros y su incidencia en el fortalecimiento de las habilidades motoras durante el desarrollo de los niños. Metodología. Se desarrolló un trabajo documental, con un diseño de investigación sistemático y nivel descriptivo. Para la recolección de información se consideró inicialmente 9 bases de datos, se consideró artículos publicados desde el 2018, en idiomas español, inglés y portugués y se excluirán casos clínicos de un paciente particular. Resultados. Luego de varios filtros se obtuvo un total de 18 artículos, con destacables resultados sobre los diferentes métodos usando en la atención temprana a neonatos prematuros. Conclusión. La atención temprana kinestésica y método de posición de canguro muestran resultados favorables para el desarrollo sensorial y contribuye al proceso de alimentación en neonatos prematuros. Área de estudio general: Rehabilitación y terapia física. Área de estudio específica: Atención temprana. Tipo de estudio: Revisión bibliográfica.
Adicción al dispositivo móvil y síntomas prefrontales en estudiantes universitarios
Authors: Cando Pilatuña Rosario Isabel , Tenezaca Sánchez Jenny Rocio , Castillo Gónzales Mayra Elizabeth , Ponce Cando Juan Paúl 
Published: January 2024

Introducción: el uso excesivo de dispositivos móviles ocasiona efectos negativos en la salud física y mental. Objetivo: establecer la relación entre la dependencia al dispositivo móvil y los síntomas prefrontales. Metodología: se realizó un estudio cuantitativo, descriptivo, correlacional, no experimental de corte transversal. La muestra estuvo constituida por 859 estudiantes de la Facultad de Ciencias de la Salud de la Universidad Nacional de Chimborazo matriculados en el periodo mayo-septiembre 2020, seleccionados por medio de un muestreo aleatorio simple. Se aplicó el Test de Dependencia al Móvil. Resultados: el 51.5 % posee un bajo uso excesivo del celular, seguido por el 34.4 % de universitarios con moderada abstinencia. En el Inventario de Síntomas Prefrontales se identificaron alteraciones en la conducta social con un 36 % en un nivel bajo, y en los síntomas prefrontales con un 35 % en un nivel grave. También, se encontraron relaciones moderadas positivas entre la dependencia al dispositivo móvil y los síntomas prefrontales. Conclusión: la adicción al dispositivo móvil en estudiantes universitarios se relaciona significativamente con los síntomas prefrontales. Área de estudio general: Psicología Clínica. Área de estudio específica: Neuropsicología. Tipo de estudio: Artículo original.
Isolation, Characterization, Evaluation and Comparative Study of Beneficial Microorganisms among the Agricultural Soil, Saline Intruded Soil and Commercial Biofertilizers
Authors: Sur Bipasha , Ahmed Md Kawser , Rani Seema , Bari Md Latiful , Alam Md Jobaer , Siddiqui Abdullah Al  Mamun , Loodh Rupak 
Published: January 2024

Degradation of soil health is a growing concern as both human health and soil microbial community are directly related to this. One of the main hazards to soil deterioration in Bangladesh is soil salinization. In this study, the microbiological status of two commercial biofertilizers, an agricultural soil, and saline soil in Bangladesh were analyzed and compared. Five saline soil samples from various agricultural fields in Satkhira, two commercial biofertilizer samples, and one agricultural soil from Hazi Danesh Agricultural University were collected to carry out this work. The saline soil sample's physicochemical properties, such as pH and salinity, were examined. Saline soil had a salinity range of 0.17-1.60 ppm and a pH range of 6.20-7.22. Five beneficial bacteria, three types of food-borne pathogen indicators, three types of soil quality indicators, and one plant pathogen indicator bacterium were selected for the microbiological investigation. The microbial status of the five beneficial bacteria was observed; for Rhizobium, the range was not detected to 7.62 log CFU/g, for Azotobacter, it ranged from 3.11 log CFU/g to 5.72 log CFU/g, for phosphate-solubilizing bacteria, it ranged from 3.87 log CFU/g to 4.69 log CFU/g, and for Bacillus, it was not detected to 4.65 log CFU/g. The helpful bacteria Pseudomonas spp. and the plant pathogen inhibitor Trichoderma spp., which are deemed important markers for soil health, were found to be absent in all the samples.
The Dhaka University Journal of Earth and Environmental Sciences, Vol. 12(1), 2023, P 29-40
Capacity Assessment of Community Clinic (CC) as an Information and Support Hub during Future Outbreaks: Lessons Learnt from the COVID-19 Outbreak
Authors: Samm A Anika , Kamal A S M Maksud , Hossain Abrar , Hossain Md Motahar , Hassan SM  Kamrul , Jahan Hasina , Hayat Tanzim , Jui Tasnim Jabin , Sifa Shamima Ferdousi , Awal A S  Nurullah 
Published: January 2024

The study delves into the potential of Community Clinics (CCs) in Bangladesh to function as crucial information and support hubs during pandemics and outbreaks. By examining both internal and external factors, including organizational structure, roles, responsibilities, infrastructure, skills, tools, existing organogram, government policies, and community clinic dynamics, the research assesses the capability of CCs in this role. Through a telephonic survey of 100 Community Health Care Providers (CHCP) and Key Informant Interviews (KII) with Community Based Health Care (CBHC) officials, valuable insights were gained. While the findings reveal that CCs may not be comprehensive treatment centers for pandemics, they can effectively serve as information and support hubs, aligning with their mandates. To enhance their efficiency in this role, upgrading the WASH sensitivity of CCs is recommended, along with other measures to improve their capacity during disease outbreaks. The study underscores the significance of recognizing CCs as vital assets in combating emerging health hazards, and strategic improvements can further strengthen their contributions in addressing public health challenges.
The Dhaka University Journal of Earth and Environmental Sciences, Vol. 12(1), 2023, P 41-56
PROBLEMATIKA KETERAMPILAN MENYIMAK DALAM KEGIATAN MENGAJAR JENJANG SMP PELAJARAN BAHASA INDONESIA
Authors: Mustikawati Widhi , Ani Rakhmawati  
Published: January 2024

ABSTRAKWe surely engage in the activity of listening both formally and informally every day; in fact, listening is a necessary component of all activities. Since listening genuinely results in both fresh and recollections from the past or new information that is received, Since engaging in listening activities can arouse one's intelligence, we can feel more deeply because our brains are driven to seek out a lot of information. Because someone has effectively adopted listening activities, curiosity has a significant impact on the brain. We feel compelled to gather a lot of data. Curiosity has a significant impact on the brain since listening actions have been successfully accepted by someone. However, not everyone believes that all listening activities are enjoyable, particularly when learning begins for junior high school students. Most people may think that hearing makes them feel tired or even overstimulated. The media is also diverse depending on how each student chooses to listen to their lesson. Some people use visual media, write, and read aloud to others. There is nothing wrong with listening exercises conducted by teachers past and present, of course, as long as they are done with the knowledge that listening must be processed in order to keep up with the times. However, as candidates or teachers, we may already be familiar with the new approach so that students can listen intently without missing anything.
Keyword: problematika menyimak, mengajar, belajar
ABSTRAKMenyimak merupakan suatu kegiatan yang tentunya kita lakukan sehari-hari secara formal maupun non-formal, kegiatan apapun dalam kehidupan kita pasti melibatkan kegitan menyimak tersebut. Karena sesungguhnya menyimak adalah kegiatan yang membuahkan sebuah ingatan baru maupun lama atapun pengengetahuan baru yang masuk, karena kegiatan menyimak tersebut bisa memancing intelegent seseorang supaya kita merasa trerpancing lebih dalam karena otak kita merasa perlu mendapatkan informasi dengan jumblah yang banyak. Rasa penasaran merupakan suatu efek yang besar bagi otak, karena kegiatan menyimak tersebut sudah berhasil diterima oleh seseorang. Namun tidak semua orang merasa semua kegiatan menyimak itu merupa hal yang menyenangkan, apalagi menyimak dalam pembelajaran dimulai bagi anak SMP sebagian besar mungkin saja menganggap menyimak merupakan hal yang membuat mengantuk bahkan juga jenuh. Apalagi didasari oleh jenis cara menyimak pelajaran setiap murid itu berbeda-beda medianya. Ada yang menggunakan media gambar, tulis, membaca sendiri, dan lainya. Tentu saaat mengetahui hal tersebut menyimak harus bisa diolah sedemikian ruma mengikuti perkembangan jaman, tidak ada yang salah dengan kegiatan menyimakn yang dilakukan guru-guru dulu maupunsekarang, tetapi kita sebagai calon/guru mungkin sudah paham dengan metode metode baru agar murid bisa menyimak dengan seksama tanpa ketinggalan.
Pyrosequencing analysis of bacterial community changes in dental unit waterlines after chlorogenic acid treatment
Authors: Li Na , Cai Qin-Ming , Hu Ni-Ya , Jiang Shu-ling , Chen Fu-Qing , Hu Qiao-Qiao , Yang Fen , He Chao-Zhu 
Published: January 2024

IntroductionThe contamination of dental unit waterlines (DUWLs) poses a significant risk of cross-infection in dentistry. Although chemical disinfectants have been effective in reducing number of bacteria, they do have limitations.MethodsThis study aimed to investigate the potential of chlorogenic acid, a natural substance with broadspectrum antibacterial properties, for treating DUWLs. Over a period of three months, we analyzed the microbial communities in 149 DUWLs samples collected from 5 dental units using high-throughput pyrophosphate sequencing. ResultsThe results revealed that chlorogenic acid treatment had a significant impact on the microbial community profile in the DUWLs, with the most significant changes occurring within the first 15 days and stabilization observed in the last 30 days. The predominant genera detected in the samples were Bacteroides, Lactobacillus, Streptococcus, Methylobacterium, and Phreatobacter. Additionally, the relative abundance of certain beneficial bacteria, such as Alloprevotella, Roseburia, and Blautia, increased, while the presence of opportunistic pathogens like Mycobacteria significantly decreased. The functional prediction analysis using the KEGG database indicated a decrease in the pathogenicity of the bacterial community in the DUWLs following chlorogenic acid treatment. DiscussionThis study introduces a novel approach for the prevention and treatment of infections associated with dental care.
Lifestyle intervention Tai Chi for adult patients with type 2 diabetes mellitus: a PRIO-harms based overview of 17 systematic reviews
Authors: Zhang Furong , Chen Xixi , Liu Xicen , Shen Xiaoyu , Liu Tianyu , Zeng Fang , Jin Rongjiang 
Published: January 2024

ObjectiveTo systematically summarize current evidence and determine the clinical effectiveness and safety of Tai Chi for type 2 diabetes mellitus (T2DM) in adults by conducting an overview of systematic reviews (SRs).MethodsA systematic search encompassing five electronic databases was conducted until July 30, 2023, to identify relevant systematic reviews (SRs) based on randomized controlled trials (RCTs) concerning Tai Chi for T2DM. The methodological quality of the included SRs was assessed using the A MeaSurement Tool to Assess systematic Reviews (AMSTAR 2) and the Risk of Bias in Systematic Reviews (ROBIS) tool. The Preferred Reporting Items for Overview of Systematic Review (PRIO-harms) checklist was used to promote a more balanced reporting of benefits and harms in this overview. Corrected covered area (CCA) was used to calculate the degree of overlapping primary studies. Primary outcome measures were glycosylated hemoglobin (HbA1c) and fasting blood glucose (FBG), while secondary outcomes encompassed health-related quality measures. The GRADE (Grades of Recommendations, Assessment, Development, and Evaluation) framework was utilized to assess the quality of evidence for the outcome measures.ResultsA total of 17 eligible SRs were included in this overview. One SR reported negative conclusions, while the remaining 16 reported positive ones on different outcomes. A total of 4 SRs reported adverse events, either absent or minor. Most of the SRs exhibited critically low quality (15/17) and a high risk of bias (14/17), as indicated by AMSTAR2 and ROBIS, respectively. The CCA was 12.14%, indicating a high degree of primary study overlapping. Evidence from 135 results for 24 outcomes concerning Tai Chi for T2DM was evaluated using the GRADE approach, most of which were rated very low.ConclusionTai Chi shows promise as a potentially effective and safe lifestyle intervention for adults with T2DM, particularly in improving HbA1c, FBG, BMI, and overall quality of life (QoL). However, these results should be cautiously interpreted due to methodological flaws observed in the current SRs and the low quality of the SRs based on GRADE. Furthermore, there is a compelling need for additional well-designed, high-quality RCTs and SRs to establish robust and conclusive evidence regarding the efficacy of Tai Chi for managing T2DM in the future.Systematic Review Registrationhttps://www.crd.york.ac.uk/PROSPERO/, identifier CRD 42019140988.
The effects of metabolic indicators and immune biomarkers on pregnancy outcomes in women with recurrent spontaneous abortion: a retrospective study
Authors: Zhang Jie , Song Zhan , Yuan Hui , Cai Zhu-Hua 
Published: January 2024

BackgroundThe etiology of recurrent spontaneous abortion (RSA) remains elusive despite specific investigations affirming the association between RSA and thyroid autoimmunity (TAI). This study explores the immunological and metabolic profiles of RSA patients exhibiting positive thyroid antibodies and their connection with the rates of first-trimester miscarriage and live births. The aim is to provide further guidance for clinical interventions.MethodsA retrospective analysis included 478 women with RSA. Thyroid profile, thyroid peroxidase antibodies, and anti-thyroglobulin antibodies were measured in all participants. The clinical characteristics and pregnancy outcomes of RSA women were compared between thyroid autoimmunity (TAI)-positive and TAI-negative patients. Significant factors associated with adverse pregnancy outcomes and risk prediction models were explored in TAI-positive patients. Correlation analysis was used to identify specific metabolic or immune biomarkers associated with thyroid autoantibodies.ResultsThe prevalence of TAI was 18.6%. Compared with women without TAI, the thyroid-stimulating hormone (TSH) concentration of TAI-positive RSA was significantly higher (2.80 ± 2.98 vs 1.89 ± 1.17, p=0.006). After 28 weeks, the live birth rate of the TAI-positive group was lower than that of the TAI-negative group, with statistical significance (p&lt;0.05). The immune biomarkers that differed between RSA women with live births and those with first-trimester miscarriages were complement C4 and interleukin-6, respectively, in TAI-negative and TAI-positive women. Then, a risk prediction model for first-trimester miscarriage was constructed for TAI-positive women with an AUC of 0.81. Finally, some factors related to thyroid peroxidase antibody (TPO-Ab) levels were explored, and it was found that TPO-Ab levels were positively correlated with free thyroxine and negatively correlated with 25 hydroxyvitamin D, interleukin-4, and fasting blood glucose in RSA patients.ConclusionTAI-positive RSA patients have higher first-trimester miscarriage rates and a lower live birth rate, which may be related to metabolic immune shifts in TAI-positive RSA patients.
Discovery of potential biomarkers for osteoporosis using LC/GC−MS metabolomic methods
Authors: Wu Yahui , Yuan Chunhua , Han Peipei , Guo Jiangling , Wang Yue , Chen Cheng , Huang Chuanjun , Zheng Kai , Qi Yiqiong , Li Jiajin , Xue Zhengjie , Lu Fanchen , Liang Dongyu , Gao Jing , Li Xingyan , Guo Qi 
Published: January 2024

PurposeFor early diagnosis of osteoporosis (OP), plasma metabolomics of OP was studied by untargeted LC/GC−MS in a Chinese elderly population to find possible diagnostic biomarkers.MethodsA total of 379 Chinese community-dwelling older adults aged ≥65 years were recruited for this study. The BMD of the calcaneus was measured using quantitative ultrasound (QUS), and a T value ≤-2.5 was defined as OP. Twenty-nine men and 47 women with OP were screened, and 29 men and 36 women were matched according to age and BMI as normal controls using propensity matching. Plasma from these participants was first analyzed by untargeted LC/GC−MS, followed by FC and P values to screen for differential metabolites and heatmaps and box plots to differentiate metabolites between groups. Finally, metabolic pathway enrichment analysis of differential metabolites was performed based on KEGG, and pathways with P ≤ 0.05 were selected as enrichment pathways.ResultsWe screened metabolites with FC&gt;1.2 or FC&lt;1/1.2 and P&lt;0.05 and found 33 differential metabolites in elderly men and 30 differential metabolites in elderly women that could be potential biomarkers for OP. 2-Aminomuconic acid semialdehyde (AUC=0.72, 95% CI 0.582-0.857, P=0.004) is highly likely to be a biomarker for screening OP in older men. Tetradecanedioic acid (AUC=0.70, 95% CI 0.575-0.818, P=0.004) is highly likely to be a biomarker for screening OP in older women.ConclusionThese findings can be applied to clinical work through further validation studies. This study also shows that metabolomic analysis has great potential for application in the early diagnosis and recurrence monitoring of OP in elderly individuals.
Challenges and pitfalls of inferring microbial growth rates from lab cultures
Authors: Ghenu Ana-Hermina , Marrec Loïc , Bank Claudia 
Published: January 2024

IntroductionAfter more than 100 years of generating monoculture batch culture growth curves, microbial ecologists and evolutionary biologists still lack a reference method for inferring growth rates. Our work highlights the challenges of estimating the growth rate from growth curve data. It shows that inaccurate estimates of growth rates significantly impact the estimated relative fitness, a principal quantity in evolution and ecology. Methods and resultsFirst, we conducted a literature review and found which methods are currently used to estimate growth rates. These methods differ in the meaning of the estimated growth rate parameter. Mechanistic models estimate the intrinsic growth rate µ, whereas phenomenological methods – both model-based and model-free – estimate the maximum per capita growth rate µmax. Using math and simulations, we show the conditions in which µmax is not a good estimator of µ. Then, we demonstrate that inaccurate absolute estimates of µ are not overcome by calculating relative values. Importantly, we find that poor approximations for µ sometimes lead to wrongly classifying a beneficial mutant as deleterious. Finally, we re-analyzed four published data sets, using most of the methods found in our literature review. We detected no single best-fitting model across all experiments within a data set and found that the Gompertz models, which were among the most commonly used, were often among the worst-fitting. DiscussionOur study suggests how experimenters can improve their growth rate and associated relative fitness estimates and highlights a neglected but fundamental problem for nearly everyone who studies microbial populations in the lab.
Study on the trade-off/synergy spatiotemporal benefits of ecosystem services and its influencing factors in hilly areas of southern China
Authors: Tan Fenglian , Lu Zhaoyan , Zeng Fusheng 
Published: January 2024

IntroductionThis study aims to investigate the factors influencing ecosystem service trade-offs/synergies (TOSs) in major agricultural production areas in the southern hilly region and to propose optimization strategies to promote ecosystem sustainability in agricultural areas.MethodsThe study used a geographical detector to analyze the determinants influencing the ecosystem service trade-offs as well as correlation analysis, geographically weighted regression (GWR), and a geographical detector to analyze the spatial and temporal evolution of ecosystem service and TOS relationships from 2000 to 2020 in Hunan Province.ResultsThe results showed that the comprehensive value of ecosystem services in Hunan Province showed an increasing trend from 2000 to 2020. With spatial heterogeneity, the areas with high values were mainly distributed in the hilly areas in the west, south, and east of Hunan Province, and the areas with low values were mainly distributed in the Dongting Lake Plain and the Xiangzhong Hilly Basin. There was a trade-off relationship between food production (FP) and all other ecosystem services, of which FP has the strongest trade-off effect with habitat quality (HQ). The synergy effect between HQ, water yield (WY), carbon storage (CS), and soil conservation (SC) shows an increasing trend. Gross domestic product (GDP) and SLOPE are the dominant factors for the strength of trade-offs between food supply and other ecosystem services, and Digital Elevation Model (DEM) and Normalized Difference Vegetation Index (NDVI) are the dominant factors for the strength of synergy effects among ecosystem services. The strength of TOS effects of ecosystem services is determined by interactions or co-influences between the two services rather than by a single component.DiscussionThe results of this study can provide a reference basis for the enhancement of ecosystem services and the sustainable planning of agricultural landscapes in the southern hilly areas.