bluuebunny/crossref_metadata_2025_split huggingface dataset:
Preferences for Genetic Testing to Predict the Risk of Developing Hereditary Cancer: A Systematic Review of Discrete Choice Experiments
Authors: Morrish N. , Snowsill T. , Dodman S. , Medina-Lara A. 
Published: February 2024

Background Understanding service user preferences is key to effective health care decision making and efficient resource allocation. It is of particular importance in the management of high-risk patients in whom predictive genetic testing can alter health outcomes. Purpose This review aims to identify the relative importance and willingness to pay for attributes of genetic testing in hereditary cancer syndromes. Data Sources Searches were conducted in Medline, Embase, PsycINFO, HMIC, Web of Science, and EconLit using discrete choice experiment (DCE) terms combined with terms related to hereditary cancer syndromes, malignancy synonyms, and genetic testing. Study Selection Following independent screening by 3 reviewers, 7 studies fulfilled the inclusion criteria, being a DCE investigating patient or public preferences related to predictive genetic testing for hereditary cancer syndromes. Data Extraction Extracted data included study and respondent characteristics, DCE attributes and levels, methods of data analysis and interpretation, and key study findings. Data Synthesis Studies covered colorectal, breast, and ovarian cancer syndromes. Results were summarized in a narrative synthesis and the quality assessed using the Lancsar and Louviere framework. Limitations This review focuses only on DCE design and testing for hereditary cancer syndromes rather than other complex diseases. Challenges also arose from heterogeneity in attributes and levels. Conclusions Test effectiveness and detection rates were consistently important to respondents and thus should be prioritized by policy makers. Accuracy, cost, and wait time, while also important, showed variation between studies, although overall reduction in cost may improve uptake. Patients and the public would be willing to pay for improved detection and clinician over insurance provider involvement. Future studies should seek to contextualize findings by considering the impact of sociodemographic characteristics, health system coverage, and insurance policies on preferences. Highlights Test effectiveness and detection rates are consistently important to respondents in genetic testing for hereditary cancer syndromes. Reducing the cost of genetic testing for hereditary cancer syndromes may improve uptake. Individuals are most willing to pay for a test that improves detection rates, identifies multiple cancers, and for which results are shared with a doctor rather than with an insurance provider.
Clinical significance of KRT7 in bladder cancer prognosis
Authors: Song Jun , Wu Ye , Chen Zhongming , Zhai Dong , Zhang Chunpei , Chen Shizhan 
Published: February 2024

Background Typically, the overexpressed keratin 7 (KRT7) is considered a validated therapeutic target and prognosis marker in bladder cancer. However, the crucial roles of KRT7 in the clinical prognosis and immune microenvironment in bladder cancer remain unclear. Methods Initially, the expression levels of KRT7 in public databases were analyzed that is,Tumor Immune Estimation Resource (TIMER) 2.0 and Gene Expression Profiling Interactive Analysis (GEPIA). Further, the clinical tissue samples from patients (n = 10 pairs) were collected to confirm the expression trends of KRT7 and detected by immunohistochemistry (IHC) analysis. Meanwhile, the relationship between KRT7 and the prognosis of bladder cancer patients was analyzed by Kaplan–Meier plotter estimation and Cox regression analysis. Finally, TIMER 2.0 and IHC staining analyses were performed to calculate the infiltration abundances of three kinds of immune cells in eligible bladder tumor samples. Results The TIMER 2.0 and GEPIA datasets suggested the differences in the expression levels of KRT7 in tumors, in which KRT7 was significantly upregulated in bladder cancer. The KRT7 expression was closely associated with patients’ gender, tumor histologic subtypes, T status, and American Joint Committee on Cancer stages. Notably, the increased KRT7 indicated poor overall survival and disease-free survival rates. Moreover, KRT7 expression could be responsible for immune infiltration in the cancer microenvironment of the bladder. Finally, the high expression level of KRT7 increased the presence of regulatory T cells (Tregs) but reduced the infiltration of CD8+ T and natural killer cells. Conclusion KRT7 as a biomarker potentiated the prediction of bladder cancer prognosis and the immune microenvironment.
The relationship between nurses’ moral courage and whistleblowing approaches
Authors: Yılmaz Şerife , Özbek Güven Gamze 
Published: February 2024

Background Whistleblowing is an action that particularly requires moral courage. Understanding the relationship between nurses’ levels of moral courage and their whistleblowing approaches is important for reducing adverse situations in healthcare services. Objectives This study aims to understand and analyze the relationship between nurses’ levels of moral courage and their whistleblowing approaches. Research design This is a descriptive and correlational study. Methods The study sample consists of 582 nurses actively working in a province in northwest Türkiye. Research data were collected using an Information Form, the Nurses’ Moral Courage Scale, and the Whistleblowing Scale. Ethical considerations Ethical approval from the ethics committee, institutional permission, and informed consent from the participants were obtained for data collection. Findings Nurses were found to perceive their moral courage as high, and their whistleblowing levels were at a moderate level. There was a significant and moderate relationship between participants’ levels of moral courage and whistleblowing levels ( p < .05). Conclusions The findings emphasize the importance of promoting moral courage and creating an appropriate environment for exposing ethical violations. This study can contribute to the development of strategies to enhance nurses’ moral courage and foster a more ethical working environment in healthcare services.
Study on the Fingerprints of Acanthopanax trifoliatus Fractions with Varying Polarities and the Relationship Between Anti-inflammatory and Antioxidant Activity Using Multivariate Analysis
Authors: Liang Zijiu , Huang Xiaohong , Jiang Lin , Lin Qinghua , Zhang Renyi , Lin Changyuan , Lai Xinghong , Xie Mengjiao , Chen Haiyan , Chen Qing , Li Fangchan 
Published: February 2024

Objectives To evaluate the Spectrum-Effect relationships between the High-Performance Liquid Chromatography (HPLC) Fingerprints of fractions with different polarities and the anti-inflammatory and antioxidant effects of A. trifoliatus and to identify its pharmacodynamic material basis. Materials and Methods Chemical Fingerprints of A. trifoliatus fractions with different polarities (all fractions and ethyl acetate, n-butanol and water fractions) were obtained by HPLC, and Principal Component Analysis (PCA) was performed. The foot swelling and prostaglandin E2 (PGE2) content in mice induced by carrageenan were used as anti-inflammatory markers, and 2,2-diphenyl-1-picrylhydrazyl (DPPH) and 2,2’-azino-bis (3-ethylbenzothiazoline-6-sulfonic acid) (ABTS) methods were used as antioxidant indicators. Moreover, the Spectrum-Effect relationship between common peaks and efficacy value was conducted by Grey Relational Analysis (GRA) and Partial Least Squares analysis (PLS). Results PCA identified three principal components, and all fractions of A. trifoliatus had good anti-inflammatory and antioxidant effects. Based on GRA and PLS analysis, peaks 1 and 2 (neochlorogenic acid), 4 and 5 (chlorogenic acid), 8, 9, 10, 11 (isochlorogenic acid B), and 12 were involved in anti-inflammatory efficacy, and peaks 1 and 2 (neochlorogenic acid), 3, 4, and 5 (chlorogenic acid), and 6, 7, 9, 10, and 13 (isochlorogenic acid A) were involved in antioxidant efficacy. Conclusion This study on the Spectrum-Effect relationship of different polar fractions of A. trifoliatus provides data to support the discovery of the pharmacodynamic material basis of the anti-inflammatory and antioxidant properties of A. trifoliatus.
Can an E-commerce Platform and its Third-Party Sellers Benefit From Each Other’s Market Entry?
Authors: Tang Christopher S. , Deng Yiting , Wang Wei , Yoo Onesun Steve 
Published: February 2024

E-commerce platforms have an informational advantage over their third-party sellers, leading to the common belief that a platform's market entry would harm sellers with similar products. However, unlike traditional retail competition, the platform and its sellers have aligned incentives: the platform's commission depends on the seller's revenue, and sellers rely on the platform to strengthen their online presence. Hence, the platform has no incentive to enter the market to harm the seller's revenue severely. This paper introduces a duopoly model where the seller is the "incumbent" and the platform is the "potential entrant". Our model captures two salient features: (a) the "reputation effect" that enables the platform to obtain a higher consumer valuation than the seller, and (b) the "spillover effect" that expands the market size when an additional entity (e.g., the platform) enters the market. Our equilibrium analysis debunks the prevailing belief about platform's entry, showing that platform's entry can enable both the platform and the seller to obtain a higher profit when the unit cost is sufficiently low and the spillover effect is sufficiently high. For robustness checks, we consider three different extensions: an alternative duopoly model with reversed roles where the platform is the incumbent and the seller is the potential entrant, a scenario with an endogenously determined spillover effect, and a simultaneous market entry/exit decision-making process. We find a consistent result across all three extensions that both seller and platform entries can mutually benefit under similar market conditions, fostering a symbiotic relationship.
Metagenomic Analysis of Bacterial Microflora in Dental and Atherosclerotic Plaques of Patients With Internal Carotid Artery Stenosis
Authors: Sato Ayako , Arai Shintaro , Sumi Kenji , Fukamachi Haruka , Miyake Satoko , Ozawa Manami , Myers Mie , Maruoka Yasubumi , Shimizu Katsuyoshi , Mizutani Tohru , Kuwata Hirotaka 
Published: February 2024

Background: Internal carotid artery stenosis is primarily attributed to atherosclerosis in the carotid artery bifurcation. Previous studies have detected oral bacteria in atherosclerotic lesions, suggesting an association between oral bacteria and atherosclerosis. In this study, we compared the bacterial flora of the atherosclerotic plaque in the carotid artery and dental plaque of patients with internal carotid artery stenosis using 16S ribosomal RNA (16S rRNA) metagenomic sequencing. Methods: Fifty-four patients who underwent internal carotid endarterectomy for internal carotid artery stenosis at the Showa University Hospital between April 2016 and February 2018 were included. Polymerase chain reaction targeting the 16S rRNA gene detected bacterial DNA in the carotid plaques of 11 cases, of which only 5 could be further analyzed. Thereafter, DNA extracted from the carotid and oral plaques of these 5 cases were analyzed using metagenomic sequencing targeting 16S rRNA. In addition, their general condition and oral conditions were evaluated. The patients were classified into symptomatic and asymptomatic groups based on the presence or absence of symptoms of transient ischemic attack, and their bacterial flora was evaluated. Results: The results demonstrated that the microflora of carotid plaques (n = 5) contained bacterial species from 55 families and 78 genera. In addition, 86.5% of the bacteria detected in the carotid plaques were also detected in oral plaques. Cariogenic and periodontopathic bacteria accounted for 27.7% and 4.7% of the bacteria in the carotid plaques, respectively. Conclusions: These results suggest that oral bacteria are directly or indirectly involved in the pathogenesis of atherosclerosis. More extensive studies of oral commensal bacteria detected in extra-oral lesions are warranted to comprehensively investigate the role of oral bacteria in the pathogenesis of systemic diseases.
The State of Artificial Intelligence in Skin Cancer Publications
Authors: Joly-Chevrier Maxine , Nguyen Anne Xuan-Lan , Liang Laurence , Lesko-Krleza Michael , Lefrançois Philippe 
Published: February 2024

Background: Artificial intelligence (AI) in skin cancer is a promising research field to assist physicians and to provide support to patients remotely. Physicians’ awareness to new developments in AI research is important to define the best practices and scope of integrating AI-enabled technologies within a clinical setting. Objectives: To analyze the characteristics and trends of AI skin cancer publications from dermatology journals. Methods: AI skin cancer publications were retrieved in June 2022 from the Web of Science. Publications were screened by title, abstract, and keywords to assess eligibility. Publications were fully reviewed. Publications were divided between nonmelanoma skin cancer (NMSC), melanoma, and skin cancer studies. The primary measured outcome was the number of citations. The secondary measured outcomes were articles’ general characteristics and features related to AI. Results: A total of 168 articles were included: 25 on NMSC, 77 on melanoma, and 66 on skin cancer. The most common types of skin cancers were melanoma (134, 79.8%), basal cell carcinoma (61, 36.3%), and squamous cell carcinoma (45, 26.9%). All articles were published between 2000 and 2022, with 49 (29.2%) of them being published in 2021. Original studies that developed or assessed an algorithm predominantly used supervised learning (66, 97.0%) and deep neural networks (42, 67.7%). The most used imaging modalities were standard dermoscopy (76, 45.2%) and clinical images (39, 23.2%). Conclusions: Most publications focused on developing or assessing screening technologies with mainly deep neural network algorithms. This indicates the eminent need for dermatologists to label or annotate images used by novel AI systems.
Fifty years of the British / Journal of Orthodontics
Authors: Benson Philip E 
Published: February 2024

Background: It is 50 years since publication of the first volume of the British Journal of Orthodontics ( BJO). Now known as the Journal of Orthodontics ( JO), the official journal of the British Orthodontic Society strives to published high quality, evidence-based research. Aim: To compare the content of articles published by the BJO in 1973–1974 with those in the JO in 2022–2023 to identify any changes over 50 years. Methods: BJO volume 1 issues 1–5 and JO volume 49 issues 2–4 and volume 50 issues 1–2 were hand-searched and full articles obtained. Some articles were excluded. The included reports were assessed using objective criteria (see Supplemental materials ). Results: Similar proportions of articles reporting the results of studies collecting data directly from participants of orthodontic interest were published ( BJO: n = 12, 26%; JO: n = 15, 23%); however, there was an increase in the proportion of articles reporting studies that collected data from a non-orthodontic patient sample ( BJO: n = 5, 11%; JO: n = 15, 23%). There was also an increase in the reporting of prospective data collection ( BJO: n = 1; 6%; JO: n = 23, 79%), but much of this research was cross-sectional ( BJO: n = 8, 50%; JO: n = 20, 69%), using convenience sampling ( BJO: n = 13, 81%; JO: n = 23, 79% of articles reporting the results of data collected from human participants). Most research was non-experimental ( BJO: n = 16, 100%; JO: n = 26, 90%). Conclusions: Some similarities in the types of reports published were found, as well as some encouraging differences. Decreasing retrospective data reports and increasing prospective data reports is welcome, but many are still non-experimental and cross-sectional. There is a need to publish more longitudinal, experimental clinical data to enhance knowledge and understanding of the effects of orthodontic treatment.
Prevalence and factors influencing bullying among Egyptian schoolchildren
Authors: Sweidan Ayman T , El-Beialy Amr R , El-Mangoury Nagwa H , Mostafa Yehya A , Dehis Heba M 
Published: February 2024

Objective: To evaluate the prevalence of bullying among schoolchildren and to study the correlation between bullying and a specific type of malocclusion, self-esteem, oral health-related quality of life (OHRQoL), the need for orthodontic treatment and socioeconomic status. Design: A cross-sectional study. Setting: Low, middle and high socioeconomic group schools in the same educational district in Cairo, Egypt. Participants: A total of 324 Egyptian schoolchildren aged 11–14 years. Methods: Validated questionnaires were used to assess self-reported bullying frequency and intensity, self-esteem and OHRQoL. The Index of Orthodontic Treatment Need (IOTN) was used to assess the orthodontic treatment need and the participants’ occlusion was classified according to the British Standard Incisors (BSI) classification. Results: Bullying was found to be prevalent in 61.7% of the sample. Regression analysis revealed that participants with a Class II division 1 incisor relationship had the highest odds ratio (OR) for predicting bullying (OR = 1.86, 95% confidence interval [CI] = 1.38–2.15). Being bullied was significantly associated with lower self-esteem (OR = 0.47, 95% CI = 0.13–0.78), worse OHRQoL (OR = 2.73, 95% CI = 1.95–3.15) and a high need for orthodontic treatment, as determined by the IOTN Dental Health Component score (OR = 1.33, 95% CI = 1.05–1.95) and IOTN Aesthetic Component score (OR = 1.52, 95% CI = 1.12–1.88). Moreover, participants in high and middle socioeconomic groups had a lower OR for predicting bullying than those in the low socioeconomic group (OR = 0.27, 95% CI = 0.13–0.54). Conclusion: The bullying prevalence among Egyptian schoolchildren aged 11–14 years was very high. The prevalence of bullying was higher in schoolchildren with higher orthodontic treatment need and Class II division 1 incisor relationship. Bullying was correlated to poor self-esteem as well as poor OHRQoL. In addition, low socioeconomic status was found to be a potential predictor for bullying.
Momordin Ic Inhibits the Partially Malignant Phenotype of Osteosarcoma Cells by Inducing Apoptosis and Autophagy
Authors: Xu Ruiqing , Huang Rui , Shi Jiandang , Chu Dawei , Yang Pengyu 
Published: February 2024

Objectives Studies have shown that Momordin Ic (MI) has an antitumor effect on liver cancer, gastric cancer, and colorectal cancer. However, its effect on osteosarcoma has not yet been reported. The purpose of this study was to explore the effect of MI on several malignant phenotypes of osteosarcoma cells. Methods CCK-8 and EdU were used to evaluate the effect of MI on the proliferation of osteosarcoma cells. Apoptosis and cell cycle were observed by flow cytometry. Monodansycadaverine (MDC) staining was used to detect autophagy. Western blot was used to evaluate apoptosis, cell cycle, autophagy, and ferroptosis. Evaluation of osteosarcoma cell migration ability by wound healing assay. Colony formation assay was used to test the ability of cloning. Transwell invasion assay was used to detect the invasion level of osteosarcoma cells. Results The results showed that MI significantly inhibited the proliferative activity of osteosarcoma cells. Z-VAD-FMK, 3-MA, and Fer-1 were administered separately, and the results showed that except for Fer-1, the other two inhibitors could reverse cell activity to different degrees. Flow cytometry showed that MI induced G0/1 cell cycle arrest and increased apoptosis. MDC showed that MI induced autophagy in osteosarcoma cells. Western blot showed that autophagy and apoptosis proteins were significantly higher in MI group. Transwell invasion assay, wound healing assay, and colony formation assay confirmed that MI could inhibit the invasion, migration, and cloning ability of osteosarcoma cells. Conclusion In conclusion, our study confirmed that MI may exert antitumor effects by inducing apoptosis and autophagy in osteosarcoma cells.
Second-Look Arthroscopy Shows Inferior Cartilage after Bone Marrow Stimulation Compared with Other Operative Techniques for Osteochondral Lesions of the Talus: A Systematic Review and Meta-Analysis
Authors: Vreeken Jelmer T. , Dahmen Jari , Stornebrink Tobias , Emanuel Kaj S. , Walinga Alex B. , Stufkens Sjoerd A.S. , Kerkhoffs Gino M.M.J. 
Published: February 2024

Objective To compare cartilage quality after different surgical interventions for osteochondral lesions of the talus (OLT), evaluated by second-look arthroscopy. Secondary aims were to report concomitant diagnoses, and to correlate cartilage quality with clinical and radiological outcomes. This review hypothesizes that the cartilage repair after bone marrow stimulation (BMS) is inferior to the other available treatment options. Methods PROSPERO ID: CRD42022311489. Studies were retrieved through PubMed, EMBASE (Ovid), and Cochrane Library. Studies were included if they reported cartilage quality after second-look investigation after surgical treatment of OLT. The primary outcome measure was the cartilage quality success and failure rates (%) per surgical intervention group. Correlations between the cartilage quality and clinical or radiological outcomes were calculated. Results Twenty-nine studies were included, comprising 586 ankles that had undergone second-look arthroscopy on average 16 months after initial surgery. The success rate for BMS was 57% (95% confidence interval [CI] = 48%-65%), for fixation (FIX) 86% (95% CI = 70%-94%), for osteo(chondral) transplantation (OCT) 91% (95% CI = 80%-96%), for cartilage implementation techniques (CITs) 80% (95% CI = 69%-88%), and for retrograde drilling 100% (95% CI = 66%-100%). The success rate of BMS was significantly lower than FIX, OCT, and CIT ( P < 0.01). There were no significant differences between other treatment groups. A moderate positive significant correlation between the Magnetic Resonance Observation of Cartilage Repair Tissue (MOCART) score and the International Cartilage Repair Society score (ICRS) was found (ρ = 0.51, P < 0.001). Conclusions Successful restoration of cartilage quality was found in the majority of surgically treated OLTs. However, BMS yields inferior cartilage quality compared with FIX, OCT, and CIT. Study Design. Systematic review and meta-analysis. Level of evidence. Level IV, systematic review and meta-analysis.