bluuebunny/crossref_metadata_2025_split huggingface dataset:
A grounded theory of how people process their cancer experiences through a mindfulness-based expressive arts group
Authors: Rieger Kendra L. , Hack Thomas F. , Duff Miriam A. , Campbell-Enns Heather J. , West Christina H. 
Published: December 2023

Abstract

Background:
Given the distress associated with cancer experiences, there is a growing interest in mindfulness-based expressive arts interventions (MBAIs) for promoting patients' well-being. Our research objective was to develop a theoretical understanding of how patients with cancer experience, use, and draw meaning from an MBAI.

Methods:
We used a constructivist grounded theory research design and gathered narrative descriptions of participants' (N = 32) MBAI experiences through semistructured interviews and field notes. Participants brought the artwork they had created in the group, facilitating art elicitation. Data were analyzed with grounded theory methods.

Results:
Participants described how the dynamic interplay of mindfulness, the arts, group sharing, and bearing witness facilitated the processing and sharing of hidden thoughts, experiences, and emotions. The group facilitated several unique meaning-making processes, including re-envisioning personal identity within disruption and loss, creating a fitting container for the exploration of diverse emotions, revisiting difficult experiences within the sensitivity of art, and visualizing hope and healing. This process resulted in important learnings and benefits for living in the here and now: relational connections, facing cancer through artistic play, discovering intuition and personal resources, learning an emotional language and a new mindset to move forward, understanding what one needs to heal, and fostering gratitude and hope.

Conclusions:
MBAIs allowed for a multimodal form of meaning making which facilitated coping, adjustment, and living well with cancer. These findings will enable practitioners to design and implement more effective health services and inform future research about this therapeutically promising approach to psychosocial oncology care.
Interventions to Promote Safety Culture in Cancer Care: A Systematic Review
Authors: Le Dan , Lim Charles H. , Fazelzad Rouhi , Morley Lyndon , Bissonnette Jean-Pierre , Powis Melanie , Krzyzanowska Monika K. 
Published: December 2023

Objectives
There is limited guidance on how to effectively promote safety culture in health care settings. We performed a systematic review to identify interventions to promote safety culture, specifically in oncology settings.

Methods
Medical Subject Headings and text words for “safety culture” and “cancer care” were combined to conduct structured searches of MEDLINE, EMBASE, CDSR, CINAHL, Cochrane CENTRAL, PsycINFO, Scopus, and Web of Science for peer-reviewed articles published from 1999 to 2021. To be included, articles had to evaluate a safety culture intervention in an oncology setting using a randomized or nonrandomized, pre-post (controlled or uncontrolled), interrupted time series, or repeated-measures study design. The review followed PRISMA guidelines; quality of included citations was assessed using the ROBINS-I risk of bias tool.

Results
Eighteen articles meeting the inclusion criteria were retained, reporting on interventions in radiation (14 of 18), medical (3 of 18), or general oncology (1 of 18) settings. Articles most commonly addressed incident learning systems (7 of 18), lean initiatives (4 of 18), or quality improvement programs (3 of 18). Although 72% of studies reported improvement in safety culture, there was substantial heterogeneity in the evaluation approach; rates of reporting of adverse events (9 of 18) or Agency for Healthcare Research and Quality Safety Culture survey results (9 of 18) were the most commonly used metrics. Most of the studies had moderate (28%) or severe (67%) risk of bias.

Conclusions
Despite a growing evidence base describing interventions to promote safety culture in cancer care, definitive recommendations were difficult to make because of heterogeneity in study designs and outcomes. Implementation of incident learning systems seems to hold most promise.
Using Manganese Enhanced Magnetic Resonance Imaging (MEMRI) to Assess Calcium Dependent Activity in Vestibular Pathways Following Linear Acceleration
Authors: Naqvi Danial , Braun Rod D. , Muca Antonela , Hali Mirabela , Holt Avril Genene 
Published: December 2023

AbstractReliable methods for repetitive and longitudinal assessment of central vestibular pathway functionin vivoare rather limited. Manganese-enhanced magnetic resonance imaging (MEMRI) has been used in various sensory systems to evaluate neuronal activity in central pathways, but MEMRI assessment of central vestibular pathways has been minimal. The present study addressed this gap in knowledge by assessing whether Mn2+can be taken up in an activity-dependent manner through voltage-gated calcium channels in the vestibular nuclear complex (VNC) and the vestibulocerebellum (VeCb) of rats with and without mild linear acceleration stimulation.R1 maps were collected prior to, one day after, and two weeks after Mn2+administration in stimulated and non-stimulated rats. Analysis of MRIR1 values showed that one day after Mn2+administration the VNC and VeCb had significantly greaterR1 values that returned to baseline levels after two weeks. Non-stimulated rats had greaterR1 values than stimulated rats. Mid rostro-caudal sections of the VNC had greaterR1 values than rostral and caudal VNC sections.R1 values also indicated that Mn2+was differentially taken up across subdivisions of the VNC and VeCb. These results correlate well with expected patterns of neuronal activity after linear acceleration. MEMRI is a sensitive tool that may be used to evaluate activity patterns in central vestibular nuclei, proving useful for studying underlying mechanisms of central vestibular dysfunction.
Validation of the Faculty Readiness to Teaching Online (FRTO) scale
Authors: Kim Stella Y. , Martin Florence 
Published: December 2023

PurposeThe current study examined several aspects of validity evidence for the Faculty Readiness to Teaching Online (FRTO) scale.Design/methodology/approachData were collected from 307 faculty in higher education. Construct validity was evidenced through an exploratory factor analysis and a reliability coefficient. Differential validity was explored using the differential item functioning analysis to explore potential bias in items due to gender and age. In addition, convergent validity was tested by correlating FRTO with years of teaching online, the primary modality of instruction and whether there is required training in online teaching by the institution.FindingsThe findings from validation showed that new factors emerged and also demonstrated differences based on instructors gender and age, as well as based on teaching experience and primary modality of teaching.Originality/valueThe findings confirmed the previous study's results (Martin et al., 2019) and provided some modifications to the instrument. The factor structure did not conform to the original four factors proposed in the instrument; instead, the newly loaded factors were course design and facilitation, course technologies, course expectations and resources and time management. The revised instrument can be presented and discussed at online teaching professional development programs to help faculty understand the core competencies they need to better instruct students.
The relationship between dynamic capabilities and global value chain upgrading: the mediating role of innovation capability
Authors: Wen Yi , Wen Shuhui 
Published: December 2023

PurposeThis study examines how dynamic capabilities (DCs) impact global value chain (GVC) upgrading and assesses the mediating role of innovation.Design/methodology/approachThe study uses a quantitative research method. The data are collected using an online questionnaire administered to respondents working in Chinese automobile manufacturers in China and Laos. The data are analyzed using structural equation modeling (SEM) and related software.FindingsThe results show that DCs and innovation capabilities (ICs) positively affect GVC upgrading and that ICs plays a mediating role between DC and GVC upgrading. Dynamic capabilities evolution (CE) mediates the relationship between DCs, ICs and GVC upgrading. Finally, differences exist in the effects of the three dimensions of DCs on ICs and GVC upgrading.Practical implicationsFocusing on the absorption and transformation of knowledge, enterprises could experience a clear enhancement of IC and CE and be more likely to obtain higher marginal returns. The study provides insights for emerging market firms to gain higher added value in internationalization.Originality/valueThis study demonstrates that different dimensions of DCs have different effects on GVC upgrading. In terms of theory, the impact of IC is considered in terms of the mediating effect of CE on IC. Differences are highlighted concerning the impact of learning capability, integrating and coordinating capability and sensing capability on the mediated relationships.
The effect of window design factors on the cooling load in hospitals wards
Authors: Almhafdy Abdulbasit , Alsehail Abdullah Mohammed 
Published: December 2023

PurposeThis paper investigates the optimization of window design factors (WDFs) in hospital buildings, particularly in government hospitals within the arid climate of the Qassim region, with the aim of achieving a better cooling load reduction. Continuous monitoring of the hospital ward section is crucial due to patients' needs, requiring optimal indoor air quality and cooling load.Design/methodology/approachThe study identifies the optimal conditions for WDF design to mitigate cooling load, including window-to-wall ratio (WWR), window orientation (WO), room size and U-value (thermal properties), effectively reduce energy consumption in terms of sensible cooling load (MWh/m2) and comply with local codes. Data collection involved a smart weather station, while the Integrated Environmental Solution Virtual Environment (IESVE) software facilitated the simulation process.FindingsKey findings reveal that larger patient rooms were about 40% more energy-efficient than smaller rooms. The northern orientation showed lower energy consumption, and specific WWRs and glazing U-values significantly affected energy loads. In an analysis of U-value changes in energy performance based on the Saudi Building Code (SBC), the presented values did not meet the minimum energy consumption standards. For a valid 40% WWR with a thermal permeability of 2.89, 0.181 MWh/m2 was consumed, while for an invalid 100% WWR with the same permeability but facing the north, 0.156 MWh/m2 was consumed, which is considered an invalid practice. It is vital to follow prescribed standards to ensure energy efficiency and avoid unnecessary costs.Originality/valueFocus lies in emphasizing the significance of adhering to prescribed standards, such as SBC, to guarantee energy efficiency and prevent unwarranted expenses. Additionally, the authors highlight the crucial role of optimizing glazing properties and allocating the WWR appropriately to achieve energy-efficient building design, accounting for diverse orientations and climatic conditions.
Untangling the threads of conservation: A closer look at restoration and preservation
Authors: Mori Akira S. , Isbell Forest 
Published: December 2023

Abstract

Global goals and targets were recently set for biodiversity conservation in the coming decade. As action plans are now being developed, it is timely and important to carefully consider where and when various strategies for conservation—such as restoration and preservation—will be most effective.

For example, there is widespread support for expanding protected areas (e.g. protecting 30% of lands and waters by 2030) and restoration (e.g. having restoration completed or underway on at least 30% of degraded lands and waters), but also concerns regarding missed opportunities, and even additional degradation of nature, resulting from the ineffective implementation of these strategies.

Here, we emphasize the importance of prioritizing the preservation of relatively intact and pristine areas when identifying protected areas, and of avoiding the common misconception that, if intact nature is degraded or lost, it can simply be restored. Even the best restorations, after many decades of investments and efforts, are only a shadow of the natural systems they are meant to recreate.

Synthesis and applications. Now that the Global Biodiversity Framework has just been set, there is a critical need to recognize their fundamental differences between the types of places that are priorities for preservation, restoration or both to make collective actions for achieving the targets and goals for nature and people.
Exploring physical function and physical activity in axial spondyloarthritis: Beyond clinical remission or low disease activity
Authors: Pei Jin , Zheng Yan , Zhang Kui , Jia Junfeng , Ding Jin , Zheng Zhaohui , Shang Lei , Zhu Ping 
Published: December 2023

AbstractObjectivesTo investigate the crucial roles of physical function (PF) and physical activity (PA) in axial spondyloarthritis (axSpA) patients, as well as their correlation with disease activity (DA), and to explore the influence of general characteristics among them.MethodsWe enrolled axSpA patients from Xijing Hospital, spanning March 2022 to August 2022. Spearman rank correlation coefficients were used to assess correlations between PA (measured by the Global Physical Activity Questionnaire [GPAQ]), PF (measured by the Assessment of Spondyloarthritis international Society Health Index [ASAS‐HI], the Short Form 36‐Item Health Survey [SF‐36], and the Bath Ankylosing Spondylitis Functional Index [BASFI]), DA, and their influencing factors. A Mann–Whitney U‐test and Kruskal–Wallis H‐test were used to compare variables between different patients grouped by sex, human leukocyte antigen B27 (HLA‐B27), hip involvement, and intensity of PA and DA.ResultsThree hundred fifty‐five axSpA patients were included. We observed a moderate to strong correlation between DA and PF in axSpA patients. PA was weakly correlated with DA or PF. DA varied significantly at different PA levels, and patients with low PA levels had poorer PF. Active patients had worse PF, less transport‐related PA, and a higher rate of hip involvement with a worse Harris Hip Score (HHS).ConclusionsWe identified a close relationship between DA, PF, and PA in axSpA patients. Further, gender, HLA‐B27, and hip involvement affected the clinical manifestation of axSpA patients. These findings demonstrate that clinical remission of axSpA patients requires a comprehensive assessment rather than a single remission of DA.
Enabling translational geroscience by broadening the scope of geriatric care
Authors: Ferrucci Luigi , Wilson David M. , Donega Stefano , Montano Monty 
Published: December 2023

AbstractGeroscience poses that core biological mechanisms of aging contribute to chronic diseases and disabilities in late life and that health span and longevity can be modulated by pharmacological and behavioral interventions. Despite strong evidence from studies in model organisms and great potentials for translation, most geriatricians remain skeptical that geroscience will help them in the day‐by‐day battle with the consequences of aging in their patients. We believe that a closer collaboration between gerontologists and geriatricians is the key to overcome this impasse. There is evidence that trajectories of health with aging are rooted in intrinsic and extrinsic exposures that occur early in life and affect the pace of molecular and cellular damage accumulation with aging, also referred to as the “pace” of biological aging. Tools that measure the pace of aging currently allow for the identification of individuals experiencing accelerated aging and at higher risk of multimorbidity and disability. What we term “Translational Geroscience”, i.e., the merger of fundamental and translational science with clinical practice, is thus poised to extend the action of geriatric care to a life course perspective. By targeting core mechanisms of aging, gerotherapeutics should be effective in treating patients with multimorbidity and disability, phenotypes that are all too common among geriatric patients nowadays. We call for initiatives that enhance the flow of ideas between gerontologists and geriatricians to facilitate the growth of translational geroscience. This approach can widen the scope of geriatric care, including a new role for geroscience in the promotion and operationalization of healthy longevity.
Physical exercise plays a role in rebalancing the bile acids of enterohepatic axis in non‐alcoholic fatty liver disease
Authors: Zhang Minyu , Xiao Biyang , Chen Xiaoqi , Ou Bingming , Wang Songtao 
Published: December 2023

AbstractNon‐alcoholic fatty liver disease (NAFLD) is considered as one of the most common diseases of lipid metabolism disorders, which is closely related to bile acids disorders and gut microbiota disorders. Bile acids are synthesized from cholesterol in the liver, and processed by gut microbiota in intestinal tract, and participate in metabolic regulation through the enterohepatic circulation. Bile acids not only promote the consumption and absorption of intestinal fat but also play an important role in biological metabolic signaling network, affecting fat metabolism and glucose metabolism. Studies have demonstrated that exercise plays an important role in regulating the composition and function of bile acid pool in enterohepatic axis, which maintains the homeostasis of the enterohepatic circulation and the health of the host gut microbiota. Exercise has been recommended by several health guidelines as the first‐line intervention for patients with NAFLD. Can exercise alter bile acids through the microbiota in the enterohepatic axis? If so, regulating bile acids through exercise may be a promising treatment strategy for NAFLD. However, the specific mechanisms underlying this potential connection are largely unknown. Therefore, in this review, we tried to review the relationship among NAFLD, physical exercise, bile acids, and gut microbiota through the existing data and literature, highlighting the role of physical exercise in rebalancing bile acid and microbial dysbiosis.
Histone deacetylase inhibitor boosts anticancer potential of fusogenic oncolytic vaccinia virus by enhancing cell–cell fusion
Authors: Nakatake Motomu , Kurosaki Hajime , Nakamura Takafumi 
Published: December 2023

AbstractOncolytic viruses have two anticancer functions: direct oncolysis and elicitation of antitumor immunity. We previously developed a novel fusogenic oncolytic vaccinia virus (FUVAC) from a non‐fusogenic vaccinia virus (VV) and, by remodeling the tumor immune microenvironment, we demonstrated that FUVAC induced stronger oncolysis and antitumor immune responses compared with non‐fusogenic VV. These functions depend strongly on cell–cell fusion induction. However, FUVAC tends to have decreased fusion activity in cells with low virus replication efficacy. Therefore, another combination strategy was required to increase cell–cell fusion in these cells. Histone deacetylase (HDAC) inhibitors suppress the host virus defense response and promote viral replication. Therefore, in this study, we selected an HDAC inhibitor, trichostatin A (TSA), as the combination agent for FUVAC to enhance its fusion‐based antitumor potential. TSA was added prior to FUVAC treatment of murine tumor B16‐F10 and CT26 cells. TSA increased the replication of both FUVAC and parental non‐fusogenic VV. Moreover, TSA enhanced cell–cell fusion and FUVAC cytotoxicity in these tumor cells in a dose‐dependent manner. Transcriptome analysis revealed that TSA‐treated tumors showed altered expression of cellular component‐related genes, which may affect fusion tolerance. In a bilateral tumor‐bearing mouse model, combination treatment of TSA and FUVAC significantly prolonged mouse survival compared with either treatment alone or in combination with non‐fusogenic VV. Our findings demonstrate that TSA is a potent enhancer of cell–cell fusion efficacy of FUVAC.
The experiences of patients, caregivers and donors on transplant journeys in Canada: A convergent parallel mixed methods study
Authors: Fox Danielle E. , Hall Marc , Thibodeau Carrie , Coldwell Kristi , Lauder Lydia , Dewell Sarah L. , Davidson Sandra J. 
Published: December 2023

AbstractIntroductionThe organ donation and transplantation (ODT) system in Canada is complex and can be challenging for individuals to navigate. We thus aimed to illuminate the experiences of individuals on transplant journeys using a patient‐oriented convergent parallel mixed‐methods approach.MethodsWe captured data on adult patients, living donors, and caregivers on transplant journeys across Canada through an online survey (n = 935) and focus groups (n = 21). The survey was comprised of 48 questions about the individuals' experiences with the living donation and transplantation system, which were analyzed descriptively. Qualitative data were analyzed using an inductive conventional content analysis approach.ResultsMost participants were female (70.1%), English speaking (92.6%) and White (87.8%). Participants' experiences were represented across six key themes: holistic person‐centred care, accountable care, collective impact, navigating uncertainty, connection and advocacy. Quantitative and qualitative data were integrated to identify five opportunities to improve the organ donation and transplantation system in Canada: enhancing mental health support, establishing formal peer support programmes, improving continuity of care, improving knowledge acquisition, and expanding resources and support.ConclusionIt is imperative that the ODT system commits to asking, listening, and learning from individuals on transplant journeys and to provide them opportunities to help improve it.
Heritable differences in abundance of bacterial rhizosphere taxa are correlated with fungal necrotrophic pathogen resistance
Authors: Pogoda Cloe S. , Keepers Kyle G. , Reinert Stephan , Talukder Zahirul I. , Smart Brian C. , Attia Ziv , Corwin Jason A. , Money Kennedy L. , Collier‐zans Erin C. E. , Underwood William , Gulya Thomas J. , Quandt C. Alisha , Kane Nolan C. , Hulke Brent S. 
Published: December 2023

AbstractHost–microbe interactions are increasingly recognized as important drivers of organismal health, growth, longevity and community‐scale ecological processes. However, less is known about how genetic variation affects hosts' associated microbiomes and downstream phenotypes. We demonstrate that sunflower (Helianthus annuus) harbours substantial, heritable variation in microbial communities under field conditions. We show that microbial communities co‐vary with heritable variation in resistance to root infection caused by the necrotrophic pathogen Sclerotinia sclerotiorum and that plants grown in autoclaved soil showed almost complete elimination of pathogen resistance. Association mapping suggests at least 59 genetic locations with effects on both microbial relative abundance and Sclerotinia resistance. Although the genetic architecture appears quantitative, we have elucidated previously unexplained genetic variation for resistance to this pathogen. We identify new targets for plant breeding and demonstrate the potential for heritable microbial associations to play important roles in defence in natural and human‐altered environments.