bluuebunny/crossref_metadata_2025_split huggingface dataset:
Vacancy-Engineered Phonon Polaritons in α-MoO3
Authors: Shcherbakov Maxim , Hussain Naveed , Sakib Mashnoon , Li Zhaoxu , Harris William , Ahmed Shehzad , Wu Ruqian , Wickramasinghe H. Kumar 
Published: November 2023

Abstract
Low-symmetry van der Waals (vdW) materials have enabled strong confinement of mid-infrared light through hyperbolic phonon polaritons (HPhPs) at the nanoscale. Yet, the bottleneck persists in manipulating the intrinsic polaritonic dispersion to drive further progress in phonon-polaritonics. Here, we present a thermomechanical strategy to manipulate HPhPs in α-MoO3 using high-pressure and temperature treatment. The hot pressing engineers the stoichiometry of α-MoO3 by controllably introducing oxygen vacancy defects (OVDs), which cause a semiconductor-to-semimetal transition. Our density functional theory (DFT) and finite-difference time-domain (FDTD) results, combined with experimental studies show that the OVDs induce a metastable metallic state by reducing the bandgap while modifying the intrinsic dielectric permittivity of α-MoO3. Photo-induced force microscopy (PiFM) confirms an average dielectric permittivity tunability of |𝚫𝜺/𝜺|≈𝟎.𝟑𝟓 within a Reststrahlen band of α-MoO3, resulting in drastic shifts in the HPhP dispersion. The polariton lifetimes for pristine
and hot-pressed flakes were measured as 0.92±0.06 and 0.86±0.11 ps, respectively, exhibiting a loss of only 7%, while the group velocity exhibited an increase of 38.8±0.2%. The OVDs in α-MoO3 provide a low-loss platform that enables active tuning of mid-infrared HPhPs and have a profound impact on applications in super-resolution imaging, nanoscale thermal manipulation, boosted molecular sensing, and on-chip photonic circuits.
Hepatitis B/C viruses upregulate TNNT1 expression to induce epithelial-mesenchymal transition and hepatocellular carcinogenesis via MTA2
Authors: zhang Xiao-Lian , Qu Haoran , Xie Yan , Xiang Tian , Ye Qifa , Yuan Yufeng , Xia Yuchen , Liu Min 
Published: November 2023

Abstract

Hepatitis B and C viruses (HBV and HCV) infection has been considered as a major cause of hepatocellular carcinoma (HCC). Although tremendous efforts have been made to understand HBV/HCV-induced tumorigenicity, the precise mechanism and the critical host factors involved HBV/HCV infection-induced HCC remain to be explored. Here, we found troponin T (TNNT1) expression was significantly upregulated in HBV/HCV-infected hepatoma cells, HCC tissues, and mouse models. HBV/HCV-induced TNNT1 binds metastasis-associated protein 2 (MTA2), causing lysosomal dysfunction and autophagy suppression, which subsequently leads to increased proliferation and epithelial-mesenchymal transition (EMT) of HCC. MTA2 promotes TNNT1 deacetylation and protects TNNT1 from ubiquitination degradation, thereby enhances TNNT1 stability and carcinogenesis effect in both cellular and mouse models. TNNT1 troponin 10-aa peptide T10 can block TNNT1-MTA2 interaction and MTA2-mediated TNNT1 deacetylation, and thus promote autophagy and suppress cell proliferation/EMT. TNNT1 troponin T10 may be promising for viral HCC therapy.
Hydrogen Bonding and Electrostatic Interaction-induced Nanochannels Enabling Fast Monovalent Ion Transport for Efficient Electrodialysis
Authors: Lin Yuqing , Zhang Yiren , Gan Ning , Zhang Jiayu , Wu Baolong , Yu Jianguo , Matsuyama Hideto , Wang Rong 
Published: November 2023

Abstract
Efficient and selective ion transport in nature is primarily facilitated by ion-conductive biological channels in cell membranes. These channels reveal an architectural design with specialized functionality. Drawing inspiration from this, our study focused on developing a monovalent ion transport membrane through interchain interactions between polybenzimidazole and sulfonated poly (ether ether ketone) to form angstrom-scale confined nanochannels. The nanochannels exhibit pronounced hydrogen-bonding interactions with hydrated multivalent ions, while rendering significant charge effects that impede their transition by compressing the effective passageways. Both hydrogen bonding and electrostatic interaction synergistically result in high selectivity of monovalent ions over multivalent ions, as the latter necessitates overcoming higher energy barriers compared to the former for transport through the nanochannels. The resulting membrane achieved high monovalent ion permeation rates of 1.35 mol·m−2·h−1 with high mono/multivalent ion selectivity for K+/Mg2+ of 56.5 and K+/Al3+ of 286. Our discoveries provide valuable strategies for developing sub-nanometer nanochannels with desired functionality that contributes to remarkably efficient ion separation via electrodialysis and beyond.
Comparison of high-flow nasal cannula oxygenation and non-invasive ventilation for postoperative pediatric cardiac surgery： A meta-analysis
Authors: Zhou Si-Jia , Chen Xiu-Hua , Liu Ying-Ying , Chen Qiang , Zheng Yi-Rong , Zhang Qi-Liang 
Published: November 2023

Abstract
Objective
To evaluate the efficacy of high-flow nasal cannula oxygenation (HFNC) versus non-invasive ventilation (NIV) in pediatric patients post-congenital heart surgery (CHS) through a meta-analysis.
Methods
A comprehensive literature search was conducted across the Chinese biomedical literature database, Vip database, CNKI, Wanfang, PubMed, Embase, Cochrane Library, and Web of Science until December 20, 2022. We selected RCTs or cohort studies that met inclusion criteria for a meta-analysis using RevMan 5.4 software.
Results
Our search yielded five publications, comprised of one randomized controlled trial and four cohort studies. Meta-analysis revealed a significant reduction in reintubation rates in children post-CHS treated with HFNC as compared to NIV [RR = 0.36, 95%CI(0.25 ~ 0.53), P < 0.00001]. There was also a notable reduction in the duration of ICU stay [MD=-4.75, 95%CI (-9.38 ~ 0.12), P = 0.04]. No statistically significant differences were observed between HFNC and NIV in terms of duration of mechanical ventilation, 24 hour PaO2, and PaCO2 post-treatment (P > 0.05). Furthermore, both groups showed no significant difference in the duration of extracorporeal circulation [MD=-8.27, 95%CI(-17.16 ~ 0.62), P = 0.07].
Conclusions
For pediatric patients post-CHS, HFNC appears to be more effective than NIV in reducing reintubation rates and shortening the CICU stay.
Epithelial-mesenchymal transition status is a remarkable biomarker for the combination treatment with avutometinib and defactinib in KRAS-mutated non-small cell lung cancer
Authors: Horinaka Mano , Yoshimura Akihiro , Yaoi Takeshi , Ono Hisako , Itoh Kyoko , Yamada Tadaaki , Takayama Koichi , Sakai Toshiyuki 
Published: November 2023

Abstract
Recent therapeutic strategies that inhibit the MAPK pathway, a key effector pathway in KRAS-mutated cancers, have attracted considerable attention. Among several molecular-targeted drugs, the RAF/MEK clamp avutometinib (VS-6766 /CH5126766/RO5126766/CKI27) is promising for patients with KRAS-mutated cancers. Although avutometinib monotherapy has shown clinical activity in patients with KRAS-mutated cancers, effective combination strategies will be important to develop. In this study, we investigated the combination of avutometinib with the focal adhesion kinase (FAK) inhibitor, defactinib, for KRAS-mutated non-small cell lung cancer (NSCLC) cells. Using a phosphorylation kinase array kit, we explored the feedback mechanism of avutometinib in KRAS-mutated NSCLC cells. We further investigated the efficacy of combining avutometinib with inhibitors of the feedback signal using in vitro and in vivo experiments. Moreover, we aimed to identify a biomarker for the efficacy of combination therapy through an in vitro study and analysis using the TCGA dataset. FAK phosphorylation/activation was increased after avutometinib treatment and synergy between avutometinib and defactinib was observed in KRAS-mutated NSCLC cells with an epithelial rather than mesenchymal phenotype. Combination therapy with avutometinib and defactinib induced apoptosis with upregulation of Bim in cancer cells with an epithelial phenotype. In cell line-derived xenograft models of epithelial phenotype KRAS-mutated NSCLC cells, the combination therapy of avutometinib and defactinib, compared with avutometinib alone, markedly regressed tumors and delayed tumor regrowth after treatment was interrupted. These results demonstrate that the epithelial-mesenchymal transition status may be a promising biomarker for the efficacy of combination therapy with avutometinib and defactinib in KRAS-mutated NSCLC.
A Robust Approach to Secure Data Encryption: AES-RSA Hybrid with Kernel Key Protection
Authors: Srivast Aviral , Kumar Aryaman 
Published: November 2023

Abstract
In the age of ubiquitous digital information, ensuring data security is a pressing concern. This research paper introduces an innovative approach to fortify data security through a combination of hybrid encryption, involving the Advanced Encryption Standard (AES) and RSA, with the integration of kernel-based key storage. The goal is to address vulnerabilities associated with traditional RSA encryption methods, especially the well-documented factorization attacks, and to present a multi-faceted security strategy that raises the bar for safeguarding sensitive data. The research journey commences by employing AES, a symmetric block cipher, to encrypt files with a 128-bit key randomly generated for each encryption instance. To add an extra layer of security, the AES key is further encrypted with a robust RSA 2048-bit public key. This initial stage represents a sound encryption approach widely used in industry and government sectors. What distinguishes this research is the novel introduction of kernel-based key storage. In this process, the contents of the RSA key are securely transferred to the kernel's user space. This affords a protected environment, within the operating system's kernel, which effectively isolates and hides sensitive key materials, thereby making it exceedingly challenging for unauthorized parties to gain access to this vital component of the encryption system. The decryption phase involves a carefully orchestrated process of retrieving the RSA key content from the kernel, utilizing the RSA private key to decrypt the AES key, and subsequently decrypting the encoded file. This multi-layered security strategy, combining AES-RSA hybrid encryption with kernel-based key storage, offers a robust defence against data breaches, unauthorized access, and mitigates the risks associated with RSA vulnerabilities. The research findings clearly demonstrate that this approach substantially strengthens data security, effectively mitigating the risks associated with RSA vulnerabilities and ensuring that sensitive information remains confidential and well-protected. This research contribution significantly advances the state of data security, reinforcing the principles of confidentiality and integrity in the ever-evolving landscape of digital information, and it is poised to become an essential addition to the field of data security and cryptography.
Estimation for the Parameters of Power Rayleigh Distributions Using Double Ranked Set Sampling with an Application to Wind Speed Data
Authors: Gul Hasan Huseyin , Kocer Nurdan Yeniay 
Published: November 2023

Abstract
In this paper, we propose to use Power Rayleigh (PR) distribution for parameter estimation under simple random sampling (SRS), ranked set sampling (RSS) and double ranked set sampling (DRSS) schemes. The sampling technique plays an important role in statistical parameter estimation problems. In the current paper, DRSS, RSS, and SRS are considered for the estimation of parameters concerning PR distribution. The maximum likelihood (ML) and the method of moment (MoM) estimators are considered and their properties are studied. An extensive Monte Carlo simulation study is conducted to assess the performances of the ML and MOM estimators in terms of biases and mean square errors (MSEs) based on DRSS, RSS, and SRS schemes. In the application part of the study, PR distribution is used for modeling the wind speed data collected on a seasonal maximum daily basis from the Giresun site, Turkey in 2016 to illustrate the usefulness of RSS and DRSS schemes under different estimators. The results show that the MOM estimator under DRSS is significantly more efficient than the SRS and RSS schemes.
Early Mortality And Morbidity Analysis Of Macrosomic Newborn Babies
Authors: tosun demet , Salihoğlu Özgül 
Published: November 2023

Abstract
Introduction: Macrosomia is defined by birth weight (BW) ≥ 4000 g, with prevalence ranging from 0.9–15% in all births. In 6.21% of term babies, DA ≥ 2500g was recorded. Term macrosomic neonates had a greater risk of neonatal early morbidity (labor-induced, cardiorespiratory, metabolic, hematological, morphological, and functional) and death than term AGA babies. Early morbidity and death in term macrosomic babies were our study's focus. Method: Newborns ≥ 2500 g from singleton pregnancies at 37–42 weeks were assessed for postnatal morbidity and death from January 2022 to June 2023. The research group consisted of babies ≥ 4000 g, whereas the control group consisted of neonates 2500–3999 g. The Clinical Research Ethics Committee approved. We moved clinical data to the computerized environment. We utilized NCSS 2020 Statistical Software. Results were assessed using a 95% confidence interval and a significance threshold of p < 0.05. The study found 4.09% (43 out of 1052) macrosomia cases. The study group had a mean birth weight of 4.2 kg with a standard deviation of 0.19 kg, whereas the control group had 3.2 kg with 0.34 kg. A substantial positive connection was found between mothers' pregnancy weight and baby birth weight, with a p-value of less than 0.05. During the first 15 minutes after delivery, the research group had substantially higher systolic and diastolic blood pressures (p < 0.05). The research group showed a substantial drop in blood sugar levels in the first postnatal hour (p < 0.01). In the macrosomic sample, insufficient postnatal care (66.6%) and the necessity for cesarean birth owing to CPD were significantly higher (p < 0.05). Morbidity differences across groups were not significant (p > 0.05). The inquiry found no deaths. Results: This research found macrosomia at the same rate as previous studies. Pregnancies without monitoring were more common in the macrosomic group than the control cohort. Mothers' prenatal weight was positively correlated with infant birth weight. The macrosomic cohort had more cesarean sections due to cephalopelvic disproportion (CPD). Birth weight was linked to a reduction in blood sugar within an hour. In the first hour, macrosomic participants had significantly lower blood glucose levels than control participants. The macrosomic group had substantially higher noninvasive arterial systolic/diastolic blood pressures in the delivery room for 15 minutes after birth.
Trends and Clinical Outcomes of Major Burns in an Underserved Minority Population within a Large Metropolitan Area: A Cross-sectional study
Authors: Gumbs Shamon , Smith Andrew , Turkmani Manar Al , Altonen Brian , Engdahl Ryan , Whittaker Vaughn 
Published: November 2023

Abstract
Introduction
Globally burn injuries are a significant cause of morbidity and mortality. The aim of this study was to analyze the characteristics and outcomes after the management major burns in an underserved minority population. This study seeks to provide awareness of trends that can aid in developing strategies to improve healthcare delivery to minority burn patients and identify correlations that can promote injury prevention.
Methods
This study is a single-center, retrospective review of data obtained from the electronic medical records from a trauma center. Patients evaluated at an urban trauma center, and admitted to the Burn ICU from March 2019 through March 2022 with a %TBSA >20 were eligible for inclusion. A total of 27 cases were eligible for inclusion based on our criteria. The primary outcome measure was in-hospital mortality.
Results
The mean age was 46, and the patient population consisted of Blacks/African Americans (48.1%), and Whites (22.2%). Most of the injuries were due to flame (66.6%), and scald (25.9%) burns. Second-degree burns were more common (44.4%). Approximately 66.6% underwent excision/grafting, with the mean time to excision being 5.5 days. Also, 55.5% of those requiring > 1 excision/grafting procedures had a LOS > 30 days. The mean TBSA burns were 35.5%. In total, 7 deaths occurred in that time period with a mortality of 25.9%. 18.5% of patients had TBSA burns > 50%, and subsequently 60% of those eventually died. Those who died were > 50 years old, with 71.4% having inhalational injury. Mean initial lactate was 5.3, with 85.7% of deaths having lactate > 4. Dialysis requirement had 100% mortality.
Conclusion
The disparity in minority burn outcomes has been poorly studied. The ability to identify trends and risk factors aids in spreading awareness, and influencing the development of culturally-appropriate burn care.
Methyl CpG binding protein MBD2 has a regulatory role on the BRCA1 gene expression in ER+, PR+ &amp; triple-negative breast cancer cells
Authors: Sahu Ram Krishna , Tandon Simran , Singh Shalini , Das Bhudev Chandra , Hedau Suresh T. 
Published: November 2023

Abstract

Background It has been shown that Resveratrol regulate BRCA1 gene expression in breast cancer cells and that MBD proteins bind to the BRCA1 gene promoter regions, the molecular link or mechanism has yet to be established. In This study aimed to evaluate the effect of MBD proteins in the regulation of BRCA1, BRCA2, and p16, genes as well as their impacts on breast cancer cells.
Methods Efficacy of resveratrol was calculated by MTT assay. The binding assay was performed by EMSA, ChIP, & MeIP assay. MBD genes & proteins expression were analyzed by qRT-PCR & western blotting. Clonogenic, migratory, and sphere formation assays were used to assess cancer cells' colony-forming, metastatic, and tumor-forming abilities. The cytotoxicity of resveratrol on cancer cells was also tested using an apoptosis assay.
Results This study found that IC50 of resveratrol was 30µM. MBD proteins bind to the BRCA1 gene promoter. Resveratrol regulates MBD genes expression, which in turn adversely influences BRCA1 gene expression and protein expression. A high concentration of Resveratrol reduced the colony & sphere formation as well as migration of cancer cells. It also increases no. of apoptotic cells in breast cancer cells.
Conclusions In conclusion MBD2 protein interact to the BRCA1 gene promoter, and resveratrol modulates MBD2 gene expression, which in turn regulates BRCA1 gene expression, and inhibits cell proliferation, migration, and induces apoptosis in ER+, PR+ & Triple negative breast cancer cells.
Impact Identification of MBD2-BRCA1 axis indicates their significant role in the induction of apoptosis and reduction of metastasis and proliferation in Breast cancer cells. Further therapy can be designed to target these MBD proteins and resveratrol could be used along with other anticancer drugs to target breast cancer.
Investigating the Drivers of Grid Electricity Demand in Nigeria: Harnessing the Power of Machine Learning and Artificial Intelligence Algorithms
Authors: Olubusoye Olusanya E. , Emmanuel Precious M. , Nwobi Lucy D. , Daramola Abayomi , Ajulo Kayode D. , Adeyanju Omosalewa T. , Oyebade Bolu J. , Adejumo Olabode , Akintande Olalekan J. 
Published: November 2023

Abstract
The electricity situation in Nigeria is epileptic, and several households rely on alternative sources of electricity to power homes and businesses. In an urban area of the country, four (4) out of every six (6) households operate an alternative electricity supply. On the other hand, individuals in rural areas can hardly afford alternative electricity sources. More so, urban individuals use mostly alternative sources that are non-renewable (such as generators), thereby causing environmental degradation and promoting Climate-related issues. The direct impact of these alternative electricity sources has led to the death of entire families due to carbon monoxide breathing by household occupants/family and caused detrimental health issues to nearby households on several occasions. To address electricity instability issues and promote a sustainable and reliable green energy future, it is worthwhile to identify the factors influencing the grid electricity demand and develop efficient models for identifying these factors and their influence on grid electricity demand. The study finds that classical algorithms are ultimately inefficient due to the multicollinearity component of the relevant features. Consequently, the study harnesses the power of Blackbox and Glassbox algorithms - Deep Neural Network (DNN) and Multivariate Adaptive Regression Spline (MARS), respectively, to investigate these factors. The two learning algorithms agreed that Nigeria's electricity demand is majorly driven by Macroeconomic and Climatology variables – with Rural population, Temperature and GDP per capita being the most relevant drivers of electricity demand in Nigeria. Given the relevance of the GDP per capita, the result implies that the discrepancies in the socioeconomic characteristics of households or individuals in Urban to Rural played a major role in the electricity demand in Nigeria. Hence, the study concludes that by addressing only Electricity problems, Nigeria will achieve fifty-three (53) percent of the global SDG agenda and greater economic development.
Vaginal microbes alter epithelial transcriptomic and epigenomic modifications providing insight into the molecular mechanisms for susceptibility to adverse reproductive outcomes
Authors: Elovitz Michal , Anton Lauren , Cristancho Ana , Ferguson Briana , Joseph Andrea , Ravel Jacques 
Published: November 2023

Abstract
The cervicovaginal microbiome is highly associated with women’s health with microbial communities dominated by Lactobacillus spp. being considered optimal. Conversely, a lack of lactobacilli and a high abundance of strict and facultative anaerobes including Gardnerella vaginalis, have been associated with adverse reproductive outcomes. However, the molecular pathways modulated by microbe interactions with the cervicovaginal epithelia remain unclear. Using RNA-sequencing, we characterize the in vitro cervicovaginal epithelial transcriptional response to different vaginal bacteria and their culture supernatants. We showed that G. vaginalis upregulated genes were associated with an activated innate immune response including anti-microbial peptides and inflammasome pathways, represented by NLRP3-mediated increases in caspase-1, IL-1β and cell death. Cervicovaginal epithelial cells exposed to L. crispatus showed limited transcriptomic changes, while exposure to L. crispatus culture supernatants resulted in a shift in the epigenomic landscape of cervical epithelial cells. ATAC-sequencing confirmed epigenetic changes with reduced chromatin accessibility. This study reveals new insight into host-microbe interactions in the lower reproductive tract and suggest potential therapeutic strategies leveraging the vaginal microbiome to improve reproductive health.