bluuebunny/crossref_metadata_2025_split huggingface dataset:
Mishaps during composite restoration: Acute allergic angioedema and contact dermatitis
Authors: Sankhyan Vanshish , Makkar Sameer , Negi Shabnam , Kaplish Ajitesh 
Published: October 2023

Abstract
Unexpected results and negligence can lead to mishaps in the dental operatory. With the trend of using tooth-colored restorations, mishaps have also increased, which are sometimes ignored due to a lack of knowledge. Although resin-based restorative materials are considered safe, their constituents can leach out and cause allergies in patients as well as dental professionals. Safe-handling of these resin-based materials is critical due to increased risk of occupational health hazards. Most of the allergies caused by resins are related to monomers based on methacrylic acid, which is found in almost all types of dentin bonding agents. Also, it is estimated that 5%–10% of all allergic contact dermatitis reports in dental professionals are due to contact with methacrylate. On the contrary, 37% phosphoric acid in etchant results in necrosis and ulcerative lesions due to vascular nature of the oral cavity. The purpose of this article is to help dentists to become aware of allergies/mishaps that can occur due to bonding agents and phosphoric acid, thereby leading to prevention and their early management.
A review of new drugs approved by the food and drug administration in 2022
Authors: Swaminathan Arjun , Vijayakumar AE , Nikhithaa P 
Published: October 2023

ABSTRACT

Introduction:
The drugs approved by the Food and Drug Administration (FDA) in 2022, for the first time for any indication or under any brand, were studied under the contexts of indications, mechanism of action, and side effects. Primary care practitioners with considering patients as a composite whole will benefit by acquainting themselves with these drugs and their indications and adverse effects.

Observations:
The drugs were approved in all, 11 for the management of neoplasia, and 5 each for hematological, neurological, and dermatological conditions. 11 of the approved drugs are monoclonal antibodies and six are small molecule inhibitors.

Conclusion:
Although the FDA’s expedited approval program allows rapid market availability of drugs for difficult to treat conditions, a quarter of the globe does not have access to essential medicines, primarily due to cost. In light of this, approval agencies must reorient approval processes to improve accessibility.
Mucormycosis in COVID-19 patients: A cross-sectional study at IGIMS, Patna
Authors: Yasmeen Tajwar , Prasad Nidhi , Kumar Vikash , Sinha Setu , Kumar Shishir , Kumar Sanjay 
Published: October 2023

Introduction:
During the second wave of COVID-19, the incidence of mucormycosis has increased more rapidly. The most common causes attributed to the rise of mucormycosis in COVID-19 are uncontrolled diabetes, the excessive use of corticosteroids, and long-term stays in the intensive care unit, organ or bone marrow transplantation, etc.

Objective:
To determine the sociodemographic and associated risk factors, pattern of disease, treatment of mucormycosis and outcome of individual at time of discharge and after three months and six months of follow-up.

Methodology:
This cross-sectional study included all treated mucormycosis cases with prior COVID-19 infection. Data collected from medical records using purposive sampling. Survivors followed up at 3 and 6 months after discharge.

Results:
In our study, we analyzed 161 mucormycosis cases identified through positive RTPCR/Rapid Antigen reports. Among them, 72% were males and 28% were females. Diabetes mellitus was present in 71.4% and hypertension in 29.8% of patients. The case-fatality rate was 6.8% at discharge, increasing to 18.6% after 3 months and 28% after 6 months of follow-up. Statistical analysis was conducted using SPSS version 15. This analysis helped us draw meaningful conclusions from the data, highlighting the impact of comorbidities and time on mucormycosis outcomes.

Conclusion:
Post-COVID mucormycosis in India was primarily observed in patients with uncontrolled diabetes, immunodeficiency due to other comorbidities, and dysfunctional immune systems.
Tribal gaps in Malaria in relation to KAP in East Godavari District, Andhra Pradesh
Authors: Sowmya Sudha Kothapalle , Amarnath Reddy Muthukuru Chadive , Sravana Kumar Gutta , Gandikota Sai Nithesh , Babu Goru Krishna 
Published: October 2023

ABSTRACT

Objectives:
To assess the level of GAPS in knowledge, attitudes and practices among tribal people regarding malaria disease. To assess the interassociation among knowledge, attitude and practices of scores.

Materials and Methods:
A cross-sectional study was performed in tribal areas of East Godavari District for a period of one year during 2013. Sample size was calculated as 1136. Multistage Random sampling method was used to identify the 4 PHC’s in 4 directions of tribal areas and sample was equally distributed. In that study subjects were selected by using a simple Random method. Data were collected by using a pre-tested, semi-structured questionnaire and results were displayed.

Setting:
Tribal area of east Godavari district, Andhra Pradesh State, India

Participants:
Study subjects were selected by simple random method

Results:
Knowledge–practice gap for source of mosquito breeding 5.99%, for the prevention of mosquito breeding sources and for the implementation of minor engineering measures it is 10.51%. For bush cutting, the knowledge practice gap is -20.07%. For potted plants, the knowledge practice gap is -8.45%. For broken pots, it is 68.93%. IRS is performed outside the house not inside the house. The KAP-GAP for screening is nil. Covering oneself with a blanket to prevent man–mosquito contact is 6.96%.

Conclusions:
In our study, we found Know-do gap or KAP-GAP in all aspects of prevention of mosquito breeding places and personal protective measures. Regarding the interassociation among knowledge, attitudes and practices, they were associated with each other with significant difference.
Phacoemulsification under Peribulbar Anesthesia: To Patch or Not
Authors: Singh Archana , Vannadil Harikrishnan , Goenka Ranjit , Bhatta Sunandan 
Published: October 2023

Introduction:
Anesthesia for cataract surgeries is undertaken in various forms. In cases under peribulbar anesthesia, there exists a practice of patching the eye for varying duration. This study has been conducted to look into the difference in the outcome and comfort of the patient with respect to the use of eye patch in an objective way.

Materials and Methods:
This is a prospective randomized observational study with controls conducted at an Ophthalmology Department of a Tertiary Care Hospital. All patients undergoing uneventful phacoemulsification with posterior chamber intraocular lens implant surgery for age-related cataracts meeting the inclusion criteria were recruited for the study.

Results:
Two hundred and seven patients were included and randomly allotted to the patch and no-patch group. The mean pain score for the no-patch group was 2.930 (standard deviation [SD] =1.4231), while the same for the patch group was 2.879 (SD = 1.3438). The symptom of watering in patch group was significantly lower than the no-patch group with a P = 0.013 by Pearson’s Chi-square test. The mean postoperative day (POD) 1 DVA among the cases was found to be 0.440 LogMAR (SD = 0.3114) and the same for controls was 0.715 LogMAR (SD = 0.2858). On the 2nd POD, the DVA of the cases improved to 0.162 LogMAR (SD = 0.1819) while that of controls were 0.419 LogMAR (SD = 0.2758). However, the visual acuity of both groups was comparable at the end of the 7th POD. The patients without patch demonstrated significantly better visual acuity on the 1st POD. This group of patients also had statistically significant reduction in the conjunctival congestion, aqueous flare, aqueous cells, and corneal edema. The beneficial outcome on the 1st POD is likely due to the early use of topical drugs which is facilitated by the absence of eye patch. However, the final outcome seems independent of the use of patching.

Conclusion:
Using an eye patch for the patient undergoing a routine phacoemulsification surgery under peribulbar block does not seem to have any additional benefit.
Bacteriological Profile of Ventilator-Associated Pneumonia in Trauma Intensive Care Unit of a Tertiary Care Hospital
Authors: Mehrotra Neetu , Karyakarte Rajesh , Sahu Rajesh , Mukherjee Bhasker 
Published: October 2023

Introduction:
Ventilator-associated pneumonia (VAP) is an important cause of increased morbidity, mortality, duration of hospital stay, and increased health-care costs. It is the second-most common hospital-acquired infection associated with high morbidity and mortality. Identification of the spectrum of causative organisms of VAP is imperative in the proper utilization of antimicrobials for VAP and the prevention of multidrug resistance (MDR) organisms.

Aim and Objective:
The spectrum of organisms responsible for VAP in the trauma center of our tertiary care hospital is not known and additionally, the ideal use of antimicrobials for proper treatment of these cases had to be formulated. This study was planned to identify the organisms and antimicrobial susceptibility patterns of bacteria causing VAP in patients admitted to trauma intensive care unit (ICU) of this tertiary care general hospital.

Materials and Methods:
In this study, 150 cases of VAP from a trauma ICU were included, who met the criteria of VAP as per the Clinical Pulmonary Infection Score. Endotracheal aspirate (ETA) samples were collected and processed for Gram stain; organisms were isolated and antibiotic sensitivity was performed by Kirby–Bauer method. Statistical analysis was performed using SSPI 23.0.0.0.

Results:
Our study showed predominantly Gram-negative bacilli (GNB) (70.6%) in the isolates, Gram-positive cocci in 4.67% of isolates, and 2% polymicrobial. The most common organism isolated was Klebsiella pneumoniae (44.08%), followed by Acinetobacter baumannii (17.77%). K. pneumoniae showed maximum resistance to cefotaxime (98.51%) and most sensitivity to colistin (13.43%). Maximum resistance was seen against cefotaxime (97.08%) and least against moxifloxacin (37.96%) and colistin (13.08%). K. pneumoniae had the highest MDR (47.6%), followed by A. baumannii (17.14%).

Conclusion:
VAP is a significant cause of mortality in ICU settings. The significant isolation of GNB in ETAs and the resistance pattern seen in our study shows that judicious and appropriate use of antimicrobials in this setting would be highly beneficial to prevent the emergence of MDR organisms and reduce mortality in cases of VAP.
Correlation between Monocyte Gene Expression and Inflammation on Brain Imaging in Patients with Solitary Cerebral Cysticercus Granuloma
Authors: Pamela Betcy Evangeline , Thamizhmaran Subashini , Manoj Josephin , Thanigachalam Anupriya , Carabin Hélène , Prabhakaran Vasudevan , Moorthy Ranjith K. , Oommen Anna , Drevets Douglas A. , Rajshekhar Vedantam 
Published: October 2023

ABSTRACT.
Prior work has shown that 14 monocyte genes are upregulated in patients with different forms of parenchymal neurocysticercosis, including solitary cysticercus granuloma (SCG). The aim of this study was to investigate whether changes in inflammation associated with SCG seen on follow-up brain imaging are also reflected in changes in expression of these 14 genes. Peripheral blood CD14+ monocytes were isolated from 20 patients with SCG at initial diagnosis and at clinical and imaging follow-up of 6 months or more. Expressions of 14 target monocyte genes were determined by quantitative polymerase chain reaction at each visit. At a median follow-up of 14 months, the SCG had resolved in 11 patients, was persistent in four patients, and had calcified in five patients. Edema seen in the initial imaging in 17 patients had resolved in 15 patients and was markedly reduced in two patients. The expression levels of the monocyte genes LRRFIP2, TAXIBP1, and MZB1 were significantly lower at follow-up, regardless of the status of SCG on follow-up imaging. Our findings show that expression levels of monocyte genes involved with inflammatory processes decrease in patients with SCG concomitant with follow-up imaging that reveals a reduction in inflammation as revealed by complete or near-complete resolution of edema, as well as resolution or reduction in the enhancement of the granuloma.
Mass-Market Augmented Reality: The Difficulty behind its Integration and the Path to Success
Authors: Guthrie McNerney Roman , Galang Brandon 
Published: October 2023

The failure of Google Glass changed the path of augmented reality (AR), delaying its integration into a mass market by years. Google Glass contained numerous technical limitations that companies are still facing today. The product also showcased the social issues that come with the technology. Shared privacy concerns among many cause consumer reluctance, with information tyrants such as Google leading and largely controlling AR development. In addition to privacy concerns, health concerns steer people away from the technology. Worse yet, the many negative connotations associated with AR give it a stigma that causes major social limitations. Without normalization of the technology, people will not be interested to invest large sums of money in a product centered on convenience rather than purpose. This lack of purpose and perceived unknowns, combined with the pragmatic elements of a low battery life and glitchy, bulky design, makes the technology unappealing. Companies today are attempting to circumnavigate these problems in multiple ways. Some are attempting to create a product with a centralized purpose that solves a problem. Others are using already established industries such as the smartphone or gaming market to sell a more manageable product. Some companies have abandoned the idea of selling AR products, and are instead using it as a service.
Augmented reality is a field that still must develop due to its initial setbacks, compelling companies to become creative with the technology’s usage. The consumer market is not adapted to wearable AR, making normalization necessary for further progression in the field.
Aplikasi SABARSON (Si Penjaga Kualitas Rumah Sakit) Sebagai Early Warning System
Authors: Maghfiroh Alfina Lailatul , Nisak Umi Khoirun 
Published: October 2023

Determining the quality of hospital service is about the efficiency of bed management. In some hospitals, Barber Johnson graphs are still described in Microsoft Excel, but the BOR indicator has not been displayed. SABARSON: The Guardian of Hospital Quality as an Early Warning System is a creative innovation in system design that can be used to determine the quality of a hospital by displaying a graph of the four indicators BOR, LOS, BTO, and TOI. This type of design uses the system development method with the development life cycle (SDLC) approach with the stage of problem identification, reference search, dataflow and concept preparation, color palette preparation, system design, and system implementation. The purpose of this study is to help and facilitate medical record workers in describing or displaying a Barber Johnson graph quickly and precisely. This study resulted in several interface design results such as login, BOR, TOI, LOS, BTO, report recapitulation, and Barber Johnson graphic.
PENERAPAN METODE GROUP INVESTIGATION (GI) TERHADAP MOTIVASI BELAJAR MAHASISWA SEMESTER II DALAM PEMBELAJARAN ILMU DASAR KEPERAWATAN
Authors: Tiara Putri Ryandini  , Moh. Ubaidillah Fiqih  , Dyah Pitaloka  , Feby Lutfiatur Rosda  
Published: October 2023

Based on the conditions experienced by the second-semester students of the Nursing Undergraduate Study Program at IIK NU Tuban, shows that motivation and learning outcomes are still low and tend to be less than optimal. One of the main causes is boredom. It's not boring teaching material, it's just that the lecturers are still not able to apply the models, strategies, methods, and learning media or approaches used. Efforts made by researchers to increase learning motivation are by applying Group Investigation (GI) learning techniques. With the application of this method, it is hoped that lecturers, students, and researchers will be able to determine the effectiveness of the Group Investigation (GI) method in increasing learning motivation for second-semester students in Learning Basic Nursing Sciences at IIK NU Tuban. This study used a pre-experimental design, with a one-group pre-test and post-test design. The sampling method used total sampling with a total of 139 respondents. The instruments used are SOPs and questionnaire sheets. The observation sheet is used to determine whether the GI method can be carried out according to the SOP. Data analysis used the Wilcoxon statistical test with SPSS 26. The results of the statistical test obtained Asymp. Sig. (2-tailed) p = 0.000 where the value of p < (0.000 < 0.05) then H1 is accepted, which means that there is an effect of the application of the Group Investigation (GI) Method on the Learning Motivation of Semester II Students in IDK Learning at IIK NU Tuban. Based on these results, it can be concluded that the application of the Group Investigation (GI) method can increase the learning motivation of second-semester students in IDK learning at IIK NU Tuban.
Anfibios (Amphibia: Anura) en el Área Recreativa Lago Gatún, Colón, Panamá
Authors: Contreras Mónica , León Voitier Juan , Walter-Conrado Manuel , Sosa-Bartuano Ángel 
Published: October 2023

El Área Recreativa Lago Gatún (ARLG), forma parte de las cuatro zonas propuestas en el Plan de Acción para el desarrollo de Turismo Verde en Áreas Protegidas de Panamá, sin embargo, hay pocos estudios sobre diversidad y conservación de sus recursos naturales, en particular su fauna, que pueda ser útil para demarcar senderos de interpretación. Con el objetivo de actualizar el listado sobre la Riqueza, Abundancia y Estado de Conservación de anfibios en el ÁRLG, se realizó entre los meses de abril y diciembre de 2021 un inventario de anfibios. Se utilizó el método de observación directa para el registro de individuos y el uso de claves taxonómicas para la identificación de las especies; los individuos no identificados in situ fueron fotografiados y contrastados con especímenes del Museo de Vertebrados de la Universidad de Panamá. Se registraron 575 individuos en 12 especies y 8 Familias. Once de las doce especies reportadas son nuevos registros para el lugar. Las especies más abundantes fueron Engystomops pustulosus y Agalychnis callidryas con 277 y 88 individuos, respectivamente. Agalychnis callidryas fue la única especie en categoría de preocupación menor de acuerdo a la UICN. El total de especies registradas para el ARLG resulta una importante contribución al conocimiento de la riqueza de anuros de la zona.
administración empresarial y la utilización de la inteligencia artificial y GPT-4 aportes y desafíos para la ingeniería del software y los sistemas de información
Authors: De Tyler Carmen , Gordon Graell Roberto , Tyler R. Cristian E. 
Published: October 2023

Dentro de las tendencias actuales a la cual se están viendo obligadas las empresas a incursionar como parte de sus funciones administrativas se encuentra la implementación de inteligencia artificial. La inteligencia artificial “es la simulación de procesos de inteligencia humana por parte de máquinas, especialmente sistemas informáticos. El objetivo de esta investigación es conocer la forma en que la Inteligencia Artificial y los sistemas de información denominados ChatGPT, son usados en el ámbito de la administración de empresas. La metodología empleada para esta investigación tiene un enfoque cualitativo.
Implementando la técnica del estado del arte, la misma es de tipo descriptiva. Los resultados señalan que la gestión empresarial, cada día se hace más compleja debido a la gran cantidad de datos que día tras día se generan, por lo que la Inteligencia Artificial resulta ser una gran oportunidad para optimizar, automatizar y reducir procesos, en beneficio de la productividad empresarial. En conclusión, el aporte científico que ha hecho la Ingeniería de Software ha resultado ser de gran apoyo, dejando como legado grandes aportes a la sociedad que, con el pasar del tiempo, han permitido que muchos procesos se reduzcan, todo en beneficio de la humanidad
The outcome of high-frequency oscillatory ventilation in pediatric patients with acute respiratory distress syndrome in an intensive care unit
Authors: Al-Ayed Tareq , Alsarhi Iyad B. , Alturki Abdullah , Aljofan Fahad , Alofisan Tariq , Abdulsalam Moath Al , Gashgarey Deema , Alrwili Rwan , Aldihan Wala , Mahfodh Saleh Badr Bin , Alanzi Fawaz , Al-Wathinani Ahmed M. , Alhuthil Raghad Tariq 
Published: October 2023

BACKGROUND:
In adults with acute respiratory distress syndrome (ARDS), high-frequency oscillatory ventilation (HFOV) has been associated with higher mortality rates. Therefore, its use in children with ARDS is still controversial.

OBJECTIVES:
Evaluate the overall mortality of HFOV in children with ARDS and explore mortality-related risk factors; compare the outcome of using HFOV post-endotracheal intubation early (≤24 hours) versus late (≤24 hours).

DESIGN:
Retrospective (medical record review)

SETTING:
Pediatric intensive care unit in a tertiary care center in Saudi Arabia.

PATIENTS AND METHODS:
Data were collected from medical records of all pediatric patients with ARDS aged one week to 14 years, who were admitted to the pediatric intensive care unit (PICU) from January 2016-June 2019 and who required HFOV.

MAIN OUTCOME MEASURES:
PICU mortality.

SAMPLE SIZE AND CHARACTERISTICS:
135 ARDS patients including 74 females (54.8%), and 61 males (45.2%), with a median age (interquar-tile range) of 35 (72) months.

RESULTS:

The overall mortality rate was 60.0% (81/135), and most died in the first 28 days in the PICU (91.3%, 74/8). Of non-survivors, 75.3% (61/81) were immunocompromised, and 24.7% (20/81) were immuno-competent patients, 52 (64.2%) received inotropic support, 40 (49.4%) had a bone-marrow transplant (BMT) before HFOV initiation. Although the prone position was used in 20.7% (28/135) to improve the survival rate post-HFOV ventilation, only 28.6% (8/28) survived. In addition, altered code status or chemotherapy reported a significant association with mortality (
P
<.05). Interestingly, early HFOV initiation (≤24 hours) did not seem to have a high impact on survival compared to late initiation (>24 hours); (57.4% vs. 42.6%,
P
=.721).

CONCLUSION:
Immunocompromised and oncology patients, including post-BMT, reported poorer outcomes, and neither the prone position nor early use of HFOV improved outcomes. However, it is recommended to replicate the study in a larger cohort to generalize the results.

LIMITATIONS:
Retrospective single-center study.