bluuebunny/crossref_metadata_2025_split huggingface dataset:
What are the changes in the hotspots and frontiers of microRNAs in hepatocellular carcinoma over the past decade?
Authors: Zhang Lu , Chen Zu-Yuan , Wei Xiao-Xian , Li Jian-Di , Chen Gang 
Published: January 2024

BACKGROUND
Emerging research suggests that microRNAs (miRNAs) play an important role in the development of hepatocellular carcinoma (HCC). A comprehensive analysis of recent research concerning miRNAs in HCC development could provide researchers with a valuable reference for further studies.
AIM
To make a comprehensive analysis of recent studies concerning miRNAs in HCC.
METHODS
All relevant publications were retrieved from the Web of Science Core Collection database. Bibliometrix software, VOSviewer software and CiteSpace software were used to visually analyze the distribution by time, countries, institutions, journals, and authors, as well as the keywords, burst keywords and thematic map.
RESULTS
A total of 9426 publications on this topic were found worldwide. According to the keywords analysis, we found that the studies of miRNAs focused on their expression level, effects, and mechanisms on the biological behaviour of HCC. Keywords bursting analysis showed that in the early years (2013–2017), “microRNA expression”, “gene expression”, “expression profile”, “functional polymorphism”, “circulating microRNA”, “susceptibility” and “mir 21” started to attract attention. In the latest phase (2018–2022), the hot topics turned to “sorafenib resistance”, “tumor microenvironment” and so on.
CONCLUSION
This study provides a comprehensive overview of the role of miRNAs in HCC development based on bibliometric analysis. The hotspots in this field focus on miRNAs expression level, effects, and mechanisms on the biological behavior of HCC. The frontiers turned to sorafenib resistance, tumor microenvironment and so on.
Identification of the key genes and mechanisms associated with transcatheter arterial chemoembolisation refractoriness in hepatocellular carcinoma
Authors: Huang Jie-Zhuang , Li Jian-Di , Chen Gang , He Rong-Quan 
Published: January 2024

BACKGROUND
Transcatheter arterial embolisation (TACE) is the primary treatment for intermediate-stage hepatocellular carcinoma (HCC) patients while some HCC cases have shown resistance to TACE.
AIM
To investigate the key genes and potential mechanisms correlated with TACE refractoriness in HCC.
METHODS
The microarray datasets of TACE-treated HCC tissues, HCC and non-HCC tissues were collected by searching multiple public databases. The respective differentially expressed genes (DEGs) were attained via limma R package. Weighted gene co-expression network analysis was employed for identifying the significant modules related to TACE non-response. TACE refractoriness-related genes were obtained by intersecting up-regulated TACE-associated and HCC-associated DEGs together with the genes in significant modules related to TACE non-response. The key genes expression in the above two pairs of samples was compared respectively via Wilcoxon tests and standard mean differences model. The prognostic value of the key genes was evaluated by Kaplan-Meier curve. Multivariate analysis was utilised to investigate the independent prognostic factor in key genes. Single-cell RNA (scRNA) sequencing analysis was conducted to explore the cell types in HCC. TACE refractoriness-related genes activity was calculated via AUCell packages. The CellChat R package was used for the investigation of the cell–cell communication between the identified cell types.
RESULTS
HCC tissues of TACE non-responders (n = 66) and TACE responders (n = 81), HCC (n = 3941) and non-HCC (n = 3443) tissues were obtained. The five key genes, DLG associated protein 5 (DLGAP5), Kinesin family member 20A (KIF20A), Assembly factor for spindle microtubules (ASPM), Kinesin family member 11 (KIF11) and TPX2 microtubule nucleation factor (TPX2) in TACE refractoriness-related genes, were identified. The five key genes were all up-regulated in the TACE non-responders group and the HCC group. High expression of the five key genes predicted poor prognosis in HCC. Among the key genes, TPX2 was an independent prognostic factor. Four cell types, hepatocytes, embryonic stem cells, T cells and B cells, were identified in the HCC tissues. The TACE refractoriness-related genes expressed primarily in hepatocytes and embryonic stem cells. Hepatocytes, as the providers of ligands, had the strongest interaction with embryonic stem cells that provided receptors.
CONCLUSION
Five key genes (DLGAP5, KIF20A, ASPM, KIF11 and TPX2) were identified as promoting refractory TACE. Hepatocytes and embryonic stem cells were likely to boost TACE refractoriness.
Restructured camel meat sausage product
Authors: Kenenbay Sh. Y. , Uzakov Y. M. , Khamza K. S. , Kulimbetova A. A. 
Published: January 2024

At present Kazakhstan cannot fully provide itself with domestic production meat, and accordingly the search for domestic raw material resources of the region is relevant. In this connection it is necessary to utilise the available resources of meat species. Possible ways of utilisation of researches and developments in the field of technology of restructured sausages from camel meat are revealed. Research determines the optimum proportions of ingredients and additives to achieve the desired texture, flavour and quality of the product. Research can lead to the development of new methods and technologies that improve the sausage making process, including restructuring of camel meat. Application of restructuring in combination with structure-forming substances allows to regulate organoleptic and structural-mechanical properties of products, to attract into production raw materials limited by traditional technologies, chemical composition of finished products, to expand the assortment, to increase the depth of processing of meat raw materials, to increase the yield of finished products and profitability of production.The research results of the technology of restructured sausages from camel meat can find practical application in various fields. In general, the practical application of the research results on the development of restructured camel meat sausage technology can contribute to product diversification, health improvement and development of new market segments. The innovative technological product in this area will be "restructured camel meat sausage". The sausage is restructured using modern technology and techniques to achieve the optimum texture and flavour of the product. The food industry can also utilise an innovative technological product such as restructured camel meat sausage. This product is part of the range of sausage and meat products available in the market.
The effect of ultrasound on the quality indicators of food raw materials and finished products
Authors: Orynbekov D. , Yessimbekov Zh. , Zhakupbekova Sh. , Maizhanova A. , Amirkhanov Sh. 
Published: January 2024

The article presents the results of a study of the effect of ultrasonic treatment on changes in the quality of meat.In most of the previous studies on the use of ultrasonic treatment, a positive effect on the quality of meat and meat products was noted. Ultrasonic processing is widespread in accelerating technological processes, improving the functional, technological and structural and mechanical properties of meat.In the course of these studies, meat samples of various animal species were subjected to ultrasound exposure of various durations, after which changes in shear stress, moisture binding capacity and microbiological parameters of pork, beef, mutton and horse meat were determined. As a result, ultrasonic processing has reduced the stress of cutting all types of meat. The optimal duration of ultrasonic treatment has been determined, which increases the moisture binding capacity of meat. As the duration of ultrasonic treatment increased, a decrease in the number of pathogenic microorganisms in meat was observed.Based on the results of these studies, it was concluded that ultrasonic treatment is important for the meat industry, since this method can be used as a non-thermal effect to improve physical, biochemical and microbiological characteristics that increase the quality, safety and increase the shelf life of various meat products.
Studies of the composition of fermented milk product obtained from combined dairy raw materials using meso-thermophilic starter culture and plant extract
Authors: Tleuova K. Zh. , Shingisov A. U. , Vetokhin S. S. , Tulekbaeva A. K. 
Published: January 2024

The dairy industry, as one of the main components of the food industry of the Republic of Kazakhstan, should not only provide the population with traditional types of milk and its processed products, but also participate in the formation of the concept of healthy nutrition by producing dairy products with new nutritional and biological properties aimed at improving the health of the population of all age categories. One of such directions is the enrichment of the composition of such products with biologically active substances from plant raw materials of local growth.Our previous studies have shown that the combination of raw milk raw materials, represented by cow's and mare's milk in a ratio of 85% and 15%, respectively, improves the physico-chemical, mineral and amino acid composition of the fermented milk product obtained from this raw material due to the presence of mare's milk in it.The use of an extract of vegetable raw materials for the enrichment of a fermented milk product is the next stage of our research on the production of functional dairy products. The article presents the results of experiments conducted to select the parameters of fermentation of the initial combined dairy raw materials with a starter culture containing meso-thermophilic cultures together with a plant extract with a study of the mineral, chemical, microbiological and amino acid composition of the resulting fermented milk product.A plant extract obtained from 6 types of medicinal plants was selected, consisting of 20 parts of hawthorn, 5 parts of sage, oregano, thyme, basil and 2.5 parts of cloves. The optimal amount of plant extract for enriching the fermented milk product has been established – no more than 3% of the total volume of the initial milk raw materials, which allows to correspond to the number of dairy microorganisms – at least 1 x 106 CFU/ cm3 , the normalized value laid down in TR CU 033/2013, and also not to worsen the organoleptic parameters of the final fermented milk product.The content of amino acids in the fermented milk product due to enrichment with plant extract, for example, arginine increases by 2.5 times, lysine by 2 times, tyrosine by 15%, phenylalanine by 25%, histidine by 33%, leucine isoleucine compared to the original dairy raw materials by 37%.
Investigation of the possibility of hop extract usage in the cheese production
Authors: Kyrykbaeva S. T. , Kalibekkyzy Z. , Kapshakbayeva Z. V. , Zhakupbekova S. K. , Ospanova B. K. 
Published: January 2024

The article presents the results of the use of plant extract from hops in the production of cheese in order to enrich it with antioxidant properties. The main material of the study was hops growing in the Abad region. It was previously shown that the protein content in ordinary hops was 1.7 times less (19%) than in baker's yeast (33%), while the tannin content in ordinary hops was quite high (3.8%). As is known, tannins have anti-ulcer, capillary-strengthening and analgesic properties, which increases the interest of researchers in using ordinary hops as functional properties.The article presents the results of studies of physico-chemical and organoleptic parameters of soft brine cheese. One of the important indicators in determining the quality of raw materials and in choosing them as raw materials for further processing is its physico-chemical properties and organoleptic characteristics. Under laboratory conditions, the results of a study were obtained to determine the physico-chemical parameters, organoleptic quality indicators of soft brine cheese.The safety parameters of hops have been studied in order to produce cheese of guaranteed quality, as well as the physico-chemical composition of raw milk. The stage of application of plant extract is determined - in the process of forming the cheese mass. Studies have also been conducted on the content of vitamin C in various cheese samples with different content of hop extract. The effect of the introduction of hop extract on the organoleptic properties of the product has been studied. It should be noted that the use of plants with antioxidant properties can significantly reduce the rate of oxidative spoilage of dairy products. The obtained results of the study allow us to consider.
Study of the effect of refrigeration treatment modes on the duration of the poultry meat cooling process
Authors: Yermolenko M. , Sanalbay Zh. , Umyrzhan T. 
Published: January 2024

Currently, more and more attention is paid to the quality of food products and especially products that are sold in a chilled state. This is due to the fact that these products have a limited shelf life and to a greater extent must retain all quality characteristics. At the same time, refrigeration processes bear the main burden in terms of energy consumption, and therefore directly affect the cost and quality of the product. In this regard, reasonable refrigeration regimes are an integral part of production. This paper presents a study of various ways of cooling chicken meat, with the simulation of various parameters of the process of heat removal in the refrigerator. The studies were carried out on an operating experimental facility at various temperatures and air speeds, both simple air cooling and air-drop cooling were carried out. In the course of the study, the duration and dependences of the temperature of the cooled sample and the drying of the product on the mode of refrigeration were established. As a result of mathematical processing for the most optimal mode, analytical dependences of the shrinkage value of the test sample were obtained.As a result of the research, the most appropriate mode of refrigeration treatment of chicken meat was recommended, which allows to reduce the weight loss of products during the cooling process.
Queijo Minas Frescal: avaliação da Qualidade e Conformidade com a Legislação
Authors: Brigido Berenice M. , Freitas Valéria P.S. , Mazon Elaine M.A. , Pisani Beatriz , Prandi Maria Ângela G. , Passos Maria Helena C.R. 
Published: January 2024

O queijo Minas Frescal é um dos produtos de laticínios mais populares do Brasil. Este trabalho teve como objetivo avaliar os resultados obtidos nas análises de amostras de queijos Minas Frescal, verificando sua conformidade com a legislação, antes e após a publicação da Instrução Normativa nº 4/2004. Foram avaliadas 22 amostras, de diferentes marcas comerciais, com registro no Serviço de Inspeção Federal (SIF). As amostras foram colhidas pelas equipes de Vigilância Sanitária em estabelecimentos varejistas de municípios abrangidos pela Direção Regional de Saúde (DIR) de Campinas, de Piracicaba e de São João da Boa Vista, em atendimento ao Programa Paulista 2002 e Programa Paulista Biênio 2003-2004. A determinação do teor de umidade e de gordura no extrato seco foi realizada segundo metodologia descrita pelo IAL (1985), as análises microbiológicas (coliformes a 45°C, estafilococos coagulase positiva, Salmonella sp e Listeria monocytogenes) foram efetuadas conforme preconizado pela APHA (1992) e a análise da rotulagem foi realizada com base na Portaria nº 371/1997, do MAA, verificando se constava na lista de ingredientes a presença de aditivos não permitidos (ácido lático). Os resultados obtidos, considerando-se a legislação em vigor no período de realização do Programa Paulista, demonstraram que 68,2% das amostras foram condenadas...
UNVEILING DUALITIES: US RHETORIC AND REALITY IN GLOBAL NUCLEAR NON-PROLIFERATION UNDER TRUMP AND BIDEN ADMINISTRATIONS
Authors: Rashid Asma , Ullah Aiman Saif 
Published: January 2024

The image the United States has always projected of itself in the international community is that of a state that is nuclear responsible and bears the responsibility to keep nuclear proliferation in check. To this effect, it uses sanctions, international pressure, and harsh language with states it deems to be in violation of the obligations of the global nuclear non-proliferation regime. On the other hand, however, there is doubt about the United States' own dedication to the cause of nuclear non-proliferation. This paper is an attempt to examine the role the US has played vis-à-vis nuclear proliferation. It deals with the question: what role US has played in promoting nuclear non-proliferation and what its probable effects are on the international nuclear non-proliferation landscape. It argues that the US has not only engaged in excessive nuclear proliferation since 1945 but has also damaged the international nuclear non-proliferation regime, thereby reduced restraints, and set dangerous precedence for other states. The paper recommends that US may lead the world towards nuclear non-proliferation and disarmament by example rather than unfair coercion.

Bibliography Entry
Rashid, Asma and Aiman Saif Ullah. 2023. "Unveiling Dualities: US Rhetoric and Realty in Global Nuclear Non-Proliferation under Trump and Biden Administrations." Margalla Papers 27 (2): 60-70.
DYNAMICS OF REGIONAL INTEGRATION IN SOUTH ASIA: LESSONS FROM THE EUROPEAN UNION
Authors: Niaz Muhammad Tariq , Shad Muhammad Riaz 
Published: January 2024

Regional integration is aimed at promoting socioeconomic growth and development in a region through economic cooperation among the member states. The European Union (EU) was established to promote economic and political cooperation among member countries. EU’s unprecedented success in regional integration offers lessons for other regions. Unlike the EU, SAARC has not been successful in achieving significant economic integration among member states. Despite its potential, SAARC has been plagued by political and economic differences among member states, especially between Pakistan and India. South Asian countries are unable to boost regional integration not only because of their political differences but also due to other sub-regional and trans-regional initiatives that run anti to the spirit of regional integration under the umbrella of SAARC. India’s role towards regional integration in South Asia is considered significant being the leading nation in the region. This paper first identifies the economic and political factors that hinder regional integration in South Asia. Then, it focuses on the dynamics of successful regional integration in Europe intending to underline the lessons to be learned by the South Asian countries to boost their regional cooperation.

Bibliography Entry
Niaz, Muhammad Tariq and Muhammad Riaz Shad. 2023. "Dynamics of Regional Integration in South Asia: Lessons from the European Union." Margalla Papers 27 (2): 85-101.
PANORAMA DOS ACIDENTES DE TRABALHO-COM CAT NA REGIÃO SUL DO BRASIL DE 2009 A 2018
Authors: Cardoso Andréa Bittencourt , Trevisol Daisson José 
Published: January 2024

Contexto: Atualmente, no Brasil, a legislação define que acidente de trabalho é aquele que ocorre durante o exercício do trabalho a serviço da empresa ou pelo exercício do trabalho dos segurados, provocando lesão corporal ou perturbação funcional, que cause a morte, a perda ou a redução, permanente ou temporária, da capacidade para o trabalho. Nesse contexto, este trabalho visa abordar o panorama de acidentes com CAT da Região Sul do Brasil. Objetivos: Identificar o panorama dos acidentes de trabalho com CAT, disponibilizados na consulta de dados da Previdência Social, que dizem respeito aos anos de 2009 a 2018, nos estados da região Sul. Métodos: Estudo observacional, do tipo ecológico, descritivo, com abordagem quantitativa, com apoio da base de dados da Previdência Social do Brasil. Foram extraídos dados dessa plataforma, como: número absoluto de acidentes de trabalho-com CAT na região sul e, selecionados por: CID, CNAE, ano, sexo, idade e UF da região sul, durante o período de 2009 a 2018. Resultados e discussão: Nos três estados da Região sul, houve queda nas taxas de incidência do total de acidentes de trabalho com CAT, assim como os típicos e doenças do trabalho, de 2009 a 2018. Os de trajeto tiveram redução, no período, apenas no Paraná. O sexo masculino e pessoas jovens representaram a maior parte dos empregados acometidos. Enquanto Rio Grande do Sul e Paraná tiveram aumento das taxas de incidência de acidentes em quatro das 10 classes de CNAE, Santa Catarina mostrou ascensão para cinco delas. Os três estados apresentaram decréscimo nas taxas de incidência de acidentes em oito dos 10 capítulos de CID. Entretanto, o percentual de aumento nos outros dois capítulos foi elevado.
EVALUASI PENGARUH ASPEK SOSIAL PROYEK PERUMAHAN CITRALAND GAMA CITY KEC. PERCUT SEI TUAN TERHADAP PERKEMBANGAN WILAYAH DISEKITAR PROYEK
Authors: Ronia Pulungan Walda , Vita Ananda Wizya , Hutagalung Irma , Leonarda Malau Pastriono , Hidayat Nasrullah 
Published: January 2024

Evaluasi ini bertujuan untuk menginvestigasi dampak proyek perumahan Citra Land Gama City di Kecamatan Percut Sei Tuan terhadap perkembangan wilayah sekitarnya. Metode penelitian mencakup survey lapangan, analisis data, dan wawancara dengan pemangku kepentingan terkait. Hasil evaluasi menunjukkan bahwa proyek ini telah memberikan kontribusi positif terhadap perkembangan wilayah, termasuk peningkatan infrastruktur, pertumbuhan ekonomi lokal, dan peningkatan kualitas hidup masyarakat sekitar. Implikasi dari temuan ini mencakup pentingnya menjaga keseimbangan antara pertumbuhan perkotaan dan pelestarian lingkungan serta perlunya perencanaan perkotaan yang berkelanjutan. Rekomendasi termasuk pemantauan terus-menerus terhadap dampak proyek ini dan kolaborasi antara pihak pengembang, pemerintah daerah, dan masyarakat untuk memastikan perkembangan wilayah yang berkelanjutan dan inklusif. Kesimpulannya, proyek perumahan Citra Land Gama City telah berperan dalam merangsang perkembangan positif wilayah sekitar proyek, sambil menekankan pentingnya tindakan berkelanjutan dalam perencanaan dan pengembangan perkotaan.