bluuebunny/crossref_metadata_2025_split huggingface dataset:
Ensino a Distância e as novas formas de mercantilização do ensino superior no Brasil
Authors: Pompeu Samira Loreto Edilberto 
Published: October 2023

O ensino a distância vem ganhando crescente espaço no Brasil nos últimos anos, com o aumento de cursos em diversas áreas, bem como de alunos em diversas partes do país. Uma análise da legislação específica sobre o tema permite compreender o terreno criado para permitir este avanço, bem como os dados estatísticos sobre EAD apresentados em relatórios nacionais mostram o crescimento e a popularização desta modalidade de ensino no país nos últimos anos. Nesse contexto, o presente trabalho busca analisar criticamente o discurso sobre o ensino a distância em revistas de mídia de negócios a partir do discurso de uma liderança desta área. Foi realizada uma análise cartográfica do discurso com base em conceitos do linguista Dominique Mainguenau e da filosofia da linguagem de Mikhail Bakhtin. Para realizar tal análise, foram selecionadas duas entrevistas do diretor-presidente da Ser Educacional, Jânio Diniz. A primeira, uma entrevista concedida ao site “Moneytimes” e a segunda derivada desta, ao site da revista “Valor Econômico”. Foi com base na perspectiva da linguagem como intervenção que este trabalho foi desenvolvido. Desejou-se aqui problematizar a presença de organizações (ou empresas) de ensino em revistas de negócios e defende-se a ideia da existência crescente da mercantilização do ensino, bem como da educação tratada como um negócio que ganha novos moldes nos dias atuais com o advento e aumento de cursos do EAD.
Study of breast cancer incidence in the population of Ukraine at the state and regional levels
Authors: Адонкіна В. Ю. , Міщенко О. Я. , Грешко Ю. І. 
Published: October 2023

Oncological diseases are the one of the most actual problems of modern medicine. In the oncological diseases structure in Ukraine breast cancer (BC) takes the first place among women.
The purpose of the study is to analyze the dynamic of the population's morbidity rates for breast cancer (BC) in Ukraine and its administrative-territorial units (regions) for 2017–2021 in order to further determine the necessary amount of costs for providing medical and pharmaceutical care.
For the analysis, official data for 2017‒2021 of the annual bulletins and other publications of the National Cancer Registry of Ukraine № 19-24 «Cancer in Ukraine» for 2017‒2021 of the SNE «National Cancer Institute» were used. Retrospective, mathematical-statistical, logical, system-analytical and comparative methods of analysis were used.
The results of the analysis of the BC incidence rates for 2017‒2021 in Ukraine showed that the minimum number of patients with BC registered in oncology dispensaries was observed in 2017 (142,097 people) with a gradual increase to 157,274 persons in 2020. In 2021, the incidence rate was 52,752 persons. In 2021, there was a sharp decrease in the incidence rate, which could have happened not due to a real decrease in incidence, but due to a decrease in the level of diagnostics, which was facilitated by quarantine restrictions regarding the coronavirus infection, the outbreak of which began in 2019.
Analysis of the dynamics of changes in the number of cases of BC in Ukraine for 2017‒2021 shows that the maximum value of the absolute increase was observed in 2017 (1,326 people), and the minimum ‒ in 2020 (-2,031 people).
The existence of significant variability of morbidity indicators in different administrative and territorial associations of the country was established. In the Rivne, Ternopil, Ivano-Frankivsk and Lviv regions, there is an increase in the number of patients with BC. The lowest incidence rates were observed in Kherson, Vinnytsia and Donetsk regions.
The large number of patients who were diagnosed with BC for the first time determines the need for effective financial support in the provision of medical and pharmaceutical assistance in order to realize the constitutional rights of citizens to receive effective medicines.
РОЗВИТОК ТВОРЧОГО ПОТЕНЦІАЛУ МАЙБУТНІХ КВАЛІФІКОВАНИХ РОБІТНИКІВ У ЗАКЛАДАХ ПРОФЕСІЙНОЇ (ПРОФЕСІЙНО-ТЕХНІЧНОЇ) ОСВІТИ
Authors: Попович Олеся , Тарасова Олена 
Published: October 2023

Актуальність: запит суспільства й економіки на підготовку в закладах професійної (професійно-технічної) освіти (далі – П(ПТ)О) креативних, ініціативних та інноваційно мислячих фахівців, здатних забезпечити швидке відновлення зруйнованої війною економіки України та подальший сталий розвиток суспільства.
Мета: здійснити теоретичний аналіз існуючих наукових поглядів на розвиток творчого потенціалу здобувачів освіти, які отримують робітничу кваліфікацію у закладах П(ПТ)О, а також визначити та обґрунтувати необхідні для цього психолого-педагогічні умови.
Методи: педагогічне спостереження – для визначення умов успішної реалізації творчого потенціалу здобувачів освіти; теоретичний аналіз наукової та науково-методичної літератури – для встановлення характерних рис творчого потенціалу; узагальнення, дедуктивний, індуктивний та логічний – для виявлення раціональних шляхів і методів виявлення творчого потенціалу здобувачів освіти.
Результати: виявлено й охарактеризовано психолого-педагогічні умови розвитку творчого потенціалу майбутніх кваліфікованих робітників у закладах П(ПТ)О.
Висновки: проаналізовано найбільш поширені погляди науковців на розвиток творчого потенціалу майбутніх фахівців у закладах П(ПТ)О та визначені необхідні для успішної реалізації психолого-педагогічні умови (підвищення їх мотивації упродовж засвоєння професійних компетентностей; посилення зв’язку між теоретичною та практичними компонентами навчального матеріалу; забезпечення взаємодії усіх учасників освітнього процесу на рівноправних демократичних засадах).
QUALIDADE DE VIDA NO TRABALHO: UM ESTUDO DE CASO EM UMA EMPRESA INDUSTRIAL DE PEQUENO PORTE DO OESTE DE SANTA CATARINA
Authors: Bragagnolo Sandra Mara , Da Rocha Cordeiro Jaine 
Published: October 2023

Cada vez mais, as organizações reconhecem que podem competir e distinguir-se haja vista seus trabalhadores. Nesse contexto, estimulá-los torna-se prioridade. Assim, a presente pesquisa busca analisar os indicadores da qualidade de vida no trabalho em uma empresa industrial de pequeno porte. Para isso, descreve-se a rotina de trabalho do setor produtivo em estudo; descreve-se o perfil dos trabalhadores; analisam-se os indicadores de qualidade de vida no trabalho; e propõem-se ações que melhorem a produtividade. Metodologicamente, o presente estudo de caso é de natureza qualitativa, quantitativa e descritiva. A coleta de dados se baseia em entrevista semiestruturada e em aplicação de questionário junto 20 trabalhadores. Os resultados mostram ser possível melhorar a qualidade de vida no trabalho e a produtividade dos trabalhadores através do reconhecimento de esforços individuais e coletivos, incentivo à prática de hábitos saudáveis, flexibilização de horários, investimento em qualificação profissional, promoção de eventos para conscientização acerca da importância das práticas que evitam acidentes e doenças ocupacionais, inserção de ginástica laboral, divulgação de mensagens de otimismo e avaliação acerca de outras formas de recompensas financeiras.
Palavras-Chave: Qualidade de vida. Trabalho. Produtividade.

Abstract: Increasingly, organizations recognize that they can compete, distinguishing by the competent employees. In this context, encouraging them becomes a priority. Therefore, the present research seeks to analyze the indicators of quality of life at work in a small industrial company. The specific objectives are: To describe the work routine of the productive sector under study; Describe the profile of employees; analyze quality of life indicators at work; and Propose actions that improve the productivity. Methodologically, the present case study is qualitative, quantitative and descriptive. Data collection is based on semi-structured interviews and application of a questionnaire with twenty employees. The results show that it is possible to improve the quality of life at work and the productivity of the employees, through the recognition of individual and collective efforts, encouraging the practice of healthy eating habits, flexible schedules when necessary, investments in greater professional qualification, promotion of events to raise awareness about the importance of practices that prevent accidents and occupational diseases, insertion of labor gymnastics, dissemination of messages of optimism and evaluation of other forms of financial rewards.
Keywords: Quality of life. Job. Productivity.
Therapeutic efficacy of omalizumab in children with moderate-to-severe allergic asthma combined with chronic sinusitis
Authors: Chong Weikun , Li Hailang , Wang Juan 
Published: October 2023

BackgroundOmalizumab has been approved for treating moderate-to-severe asthma in children aged over 6 years. Its application to asthmatic children with other allergic diseases has been rarely explored. The present study aims to explore the therapeutic efficacy of omalizumab in children with moderate-to-severe allergic asthma combined with chronic sinusitis.MethodsThe clinical data of children diagnosed with moderate-to-severe allergic asthma combined with chronic sinusitis and treated with omalizumab between September 2020 and April 2022 were retrospectively analyzed. Lung function indexes such as Childhood Asthma Control Test (C-ACT) scores, fractional exhaled nitric oxide (FeNO), and forced expiratory volume in the first second (FEV1) percent predicted (FEV1%pred), small airway function indexes, and the clinical symptoms of chronic sinusitis were analyzed.ResultsA total of 26 children were observed for 16 weeks. After 16 weeks of omalizumab treatment, the significantly increased C-ACT scores (15.57 ± 3.25 points vs. 24.98 ± 5.21 points, F = 15.7112, P &lt; 0.001) and decreased FeNO (31.55 ± 15.57 ppb vs. 19.86 ± 9.80 ppb, F = 4.4265, P = 0.0022), compared with those at baseline, were suggestive of well-controlled symptoms of asthma and improved lung function. FEV1%pred and FEV1/forced vital capacity (FVC) ratio (the ratio of the forced expiratory volume in the first 1 s to the forced vital capacity) increased after omalizumab treatment, although no significant differences were detected (P = 0.9954 and 0.9382, respectively). Peak expiratory flow (PEF) percent predicted (PEF%pred) and forced expiratory flow at 75% of FVC (FEF75%), 50% of FVC (FEF50%), and 25%–75% of FVC (FEF25%–75%) significantly increased after omalizumab treatment (P = 0.0477, &lt;0.001, &lt;0.001, and &lt;0.001, respectively). Visual analog scale scores significantly decreased after omalizumab treatment (6.40 ± 2.98 points vs. 0.85 ± 0.40 points, t = 27.2419, P &lt; 0.001), suggesting alleviation in the clinical symptoms of chronic sinusitis.ConclusionIn this study, it was found that omalizumab can effectively alleviate clinical symptoms and improve lung function and quality of life in children with moderate-to-severe allergic asthma combined with chronic sinusitis.
Alterations of lower respiratory tract microbiome and short-chain fatty acids in different segments in lung cancer: a multiomics analysis
Authors: Zhang Yong , Chen Xiangxiang , Wang Yuan , Li Ling , Ju Qing , Zhang Yan , Xi Hangtian , Wang Fahan , Qiu Dan , Liu Xingchen , Chang Ning , Zhang Weiqi , Zhang Cong , Wang Ke , Li Ling , Zhang Jian 
Published: October 2023

IntroductionThe lower respiratory tract microbiome is widely studied to pinpoint microbial dysbiosis of diversity or abundance that is linked to a number of chronic respiratory illnesses. However, it is vital to clarify how the microbiome, through the release of microbial metabolites, impacts lung health and oncogenesis.MethodsIn order to discover the powerful correlations between microbial metabolites and disease, we collected, under electronic bronchoscopy examinations, samples of paired bronchoalveolar lavage fluids (BALFs) from tumor-burden lung segments and ipsilateral non-tumor sites from 28 lung cancer participants, further performing metagenomic sequencing, short-chain fatty acid (SCFA) metabolomics, and multiomics analysis to uncover the potential correlations of the microbiome and SCFAs in lung cancer.ResultsIn comparison to BALFs from normal lung segments of the same participant, those from lung cancer burden lung segments had slightly decreased microbial diversity in the lower respiratory tract. With 18 differentially prevalent microbial species, including the well-known carcinogens Campylobacter jejuni and Nesseria polysaccharea, the relative species abundance in the lower respiratory tract microbiome did not significantly differ between the two groups. Additionally, a collection of commonly recognized probiotic metabolites called short-chain fatty acids showed little significance in either group independently but revealed a strong predictive value when using an integrated model by machine learning. Multiomics also discovered particular species related to SCFAs, showing a positive correlation with Brachyspira hydrosenteriae and a negative one with Pseudomonas at the genus level, despite limited detection in lower airways. Of note, these distinct microbiota and metabolites corresponded with clinical traits that still required confirmation.ConclusionsFurther analysis of metagenome functional capacity revealed that genes encoding environmental information processing and metabolism pathways were enriched in the lower respiratory tract metagenomes of lung cancer patients, further supporting the oncogenesis function of various microbial species by different metabolites. These findings point to a potent relationship between particular components of the integrated microbiota-metabolites network and lung cancer, with implications for screening and diagnosis in clinical settings.
Midterm prognosis following total correction of tetralogy of fallot in adult patients
Authors: Khajali Zahra , Mohammadi Nasibeh , Toloueitabar Yaser , Maleki Majid , Saedi Sedigheh , nourouzi Zeinab , Mazloum-Zadeh Saeideh , Chenaghloo Maryam , Jalali Amirhossein , Tatari Hassan , Aliramezany Maryam 
Published: October 2023

BackgroundTetralogy of Fallot is a common congenital heart disease characterized by cyanosis. The primary treatment approach involves corrective surgery typically performed within the first year of life to achieve complete resolution. However, certain patients may undergo surgery at an older age. This study seeks to assess the efficacy of surgery by examining the midterm outcomes of total correction of Tetralogy of Fallot when performed in older individuals.MethodsThis interventional-longitudinal study focused on patients who underwent complete surgery to correct tetralogy of Fallot at an advanced age of over 15 years. All of the participants were referred to the Shahid Rajaei Heart and Vascular Center, which is a referral center for congenital heart diseases in Iran, between 2010 and 2020. The surgical procedures for these patients involved primary total correction of tetralogy of Fallot or surgery following by shunt implantation. Prior to the surgery, the necessary information was gathered from the patients' medical records. The patients were then monitored over a 5-year period, during which they received regular check-ups from cardiologist with fellowship in adult congenital heart disease.ResultsA total of 94 participants were enrolled in the study, with an average age of 26.7 ± 9.6 years. Notably, the majority of the participants were male. The study reported a late mortality rate of 3.2%. Furthermore, 17 patients, constituting 18% of the cohort, underwent a secondary surgical procedure. This secondary surgery encompassed 14 cases of Pulmonary Valve Replacement (14.8%) and 3 cases of Ventricular Septal Defect repair (3.1%).ConclusionWhile the optimal age for total correction of Tetralogy of Fallot is conventionally considered to be within the first year of life, this study demonstrated that surgical intervention performed at a later stage of life can yield favorable midterm prognoses. It is imperative to emphasize that individuals unable to undergo surgery at the ideal age due to a multitude of factors should not be deprived of the potential benefits associated with surgical intervention.
Metabolism of pancreatic neuroendocrine tumors: what can omics tell us?
Authors: Jannin Arnaud , Dessein Anne-Frédérique , Do Cao Christine , Vantyghem Marie-Christine , Chevalier Benjamin , Van Seuningen Isabelle , Jonckheere Nicolas , Coppin Lucie 
Published: October 2023

IntroductionReprogramming of cellular metabolism is now a hallmark of tumorigenesis. In recent years, research on pancreatic neuroendocrine tumors (pNETs) has focused on genetic and epigenetic modifications and related signaling pathways, but few studies have been devoted to characterizing the metabolic profile of these tumors. In this review, we thoroughly investigate the metabolic pathways in pNETs by analyzing the transcriptomic and metabolomic data available in the literature.MethodologyWe retrieved and downloaded gene expression profiles from all publicly available gene set enrichments (GSE43797, GSE73338, and GSE117851) to compare the differences in expressed genes based on both the stage and MEN1 mutational status. In addition, we conducted a systematic review of metabolomic data in NETs.ResultsBy combining transcriptomic and metabolomic approaches, we have identified a distinctive metabolism in pNETs compared with controls without pNETs. Our analysis showed dysregulations in the one-carbon, glutathione, and polyamine metabolisms, fatty acid biosynthesis, and branched-chain amino acid catabolism, which supply the tricarboxylic acid cycle. These targets are implicated in pNET cell proliferation and metastasis and could also have a prognostic impact. When analyzing the profiles of patients with or without metastasis, or with or without MEN1 mutation, we observed only a few differences due to the scarcity of published clinical data in the existing research. Consequently, further studies are now necessary to validate our data and investigate these potential targets as biomarkers or therapeutic solutions, with a specific focus on pNETs.
Live cell in situ lysosomal GCase activity correlates to alpha-synuclein levels in human differentiated neurons with LRRK2 and GBA1 mutations
Authors: Labrador-Garrido Adahir , Zhong Siying , Hughes Laura , Keshiya Shikara , Kim Woojin S. , Halliday Glenda M. , Dzamko Nicolas 
Published: October 2023

IntroductionHeterozygous mutations in GBA1, which encodes the lysosomal hydrolase glucocerebrosidase (GCase), are a common risk factor for the neurodegenerative movement disorder Parkinson's disease (PD). Consequently, therapeutic options targeting the GCase enzyme are in development. An important aspect of this development is determining the effect of potential modifying compounds on GCase activity, which can be complicated by the different methods and substrate probes that are commonly employed for this purpose.MethodsIn this study, we employed the GCase substrate probe 5-(pentafluorobenzoylamino)fluorescein di-D-glucopyranoside (PFB-FDGlu) in combination with live cell imaging to measure GCase activity in situ in the lysosome.ResultsThe live cell assay was validated using the GCase inhibitor conduritol-B-epoxide and with GBA1 knockout neural cells and was then used to assess GCase activity in iPSC differentiated into neural stem cells and neurons that were obtained from idiopathic PD patients and PD patients with the LRRK2 G2019S and GBA N370S mutations, as well as controls (n = 4 per group). Heterogeneity in GCase activity was observed across all groups. However, a significant inverse correlation between GCase activity and levels of alpha-synuclein protein was observed.DiscussionThe live cell imaging assay for GCase activity could be useful for further understanding the role of GCase in PD and screening potential modifying compounds in differentiated human cell models.
Lactation physiokinetics—using advances in technology for a fresh perspective on human milk transfer
Authors: Francis Jimi , Flynn Paul , Naowar Maisha , Indic Premananda , Dickton Darby 
Published: October 2023

IntroductionThough the nature of breastfeeding is critical, scant information is available on how the action of the milk transfer from mother to infant is regulated in humans, where the points of dysfunction are, and what can be done to optimize breastfeeding outcomes. While better therapeutic strategies are needed, before they can be devised, a basic scientific understanding of the biomechanical mechanisms that regulate human milk transfer from breast to stomach must first be identified, defined, and understood.MethodsCombining systems biology and systems medicine into a conceptual framework, using engineering design principles, this work investigates the use of biosensors to characterize human milk flow from the breast to the infant's stomach to identify points of regulation. This exploratory study used this framework to characterize Maternal/Infant Lactation physioKinetics (MILK) utilizing a Biosensor ARray (BAR) as a data collection method.ResultsParticipants tolerated the MILKBAR well during data collection. Changes in breast turgor and temperature were significant and related to the volume of milk transferred from the breast. The total milk volume transferred was evaluated in relation to contact force, oral pressure, and jaw movement. Contact force was correlated with milk flow. Oral pressure appears to be a redundant measure and reflective of jaw movements.DiscussionNipple and breast turgor, jaw movement, and swallowing were associated with the mass of milk transferred to the infant's stomach. More investigation is needed to better quantify the mass of milk transferred in relation to each variable and understand how each variable regulates milk transfer.
Modular Distance Learning in the New Normal: Challenges on its Implementation
Authors: Junpel Acut 
Published: October 2023

This basic research was conducted to determine the challenges of teachers in the implementation of modular distance learning in the new normal of the public elementary and secondary schools in the District of Gitagum, Division of Misamis Oriental. Specifically, it sought to: a) describe the characteristics of the respondents; b) determine the challenges encountered by the teachers in terms of accessibility, availability of resources, support to learners, teachers’ competence and teaching strategies, assessment, and health and safety measures; c) determine the significant relationship between the respondents’ challenges and their characteristics; and d) come up with an intervention plan based on the results of the study. The respondents of the study were the one hundred five (144) public school teachers in the District of Gitagum, Division of Misamis Oriental. A researcher-made survey questionnaire was employed to obtain specific information about the study. The data were analyzed using descriptive statistics such as frequency counting of data, percentage, mean and standard deviation. Pearson Product Moment of Correlation was employed to test the significant relationship between the respondent’s challenges and their characteristics. An intervention plan was designed to help teachers in finding solutions to the challenges they are facing in the implementation of modular distance learning. The teachers’ challenges were low in the implementation of modular distance learning. It suggests that teachers faced few challenges or that the challenges they encountered were of low intensity. In other words, it implies that teachers found it relatively manageable to implement modular distance learning, and the difficulties they encountered were not severe. Teachers’ challenges were significant to sex, position, teaching experience and attitudes towards modular distance learning in the new normal. It is recommended that teachers seek support from stakeholders and the local government to acquire funds for better implementation.