bluuebunny/crossref_metadata_2025_split huggingface dataset:
Prevalence and prognosis of acute ischemic stroke coexisting with unruptured intracranial aneurysms
Authors: Yan Yujia , An Xingwei , Ren Hecheng , Luo Bin , Han Jin , Jin Song , Liu Li , Huang Ying 
Published: November 2023

ObjectivesThe prevalence of unruptured intracranial aneurysms (UIAs) in the acute ischemic stroke (AIS) cohort is probably higher than in the general population. This study investigated the prevalence of UIAs in AIS patients and the management risk and prognosis when treating AIS.MethodsFrom January 2020 to January 2023, we conducted a single-center retrospective study at Tianjin Huanhu Hospital. Each patient underwent both brain MRI and MRA/CTA to diagnose AIS and UIAs. Clinical, radiologic, and therapeutic data during hospitalization and prognosis were analyzed. Propensity-score matching (PSM) was performed to evaluate the risk of in-hospital adverse events, unfavorable outcomes at discharge when receiving post-stroke treatment and stroke recurrence.ResultsIn all, 2,181 AIS patients were included, of whom 270 had UIAs (12.4%; 95%CI 11.0–13.8%). From the unmatched and matched cohort, the incidence of in-hospital adverse events and unfavorable outcomes at discharge in patients with UIAs were not significantly different; the risk of stroke recurrence was significantly higher in patients with UIAs than in those without (unmatched: aHR, 1.71 [1.08–2.70]; matched: aHR, 2.55 [1.16–5.58]). Multivariable Cox regression models showed that aneurysm size and the presence of homoregional infarction associated with higher risk of recurrence (unmatched: aHR, 1.31 [1.21–1.41] and aHR, 3.50 [1.52–8.10]; matched: aHR, 1.28 [1.18–1.40]; p &lt; 0.001 and aHR, 3.71 [1.12–12.34]).ConclusionThe UIAs may not increase the risk of in-hospital adverse events and unfavorable outcomes at discharge in receiving post-stroke treatment, but it may associated with a high risk of stroke recurrence.
Relationship between BMI and prognosis of chronic heart failure outpatients in Vietnam: a single-center study
Authors: Nguyen Hoai Thi Thu , Ha Thuong Thi Thu , Tran Hieu Ba , Nguyen Dung Viet , Pham Hung Manh , Tran Phuong Minh , Pham Tuan Minh , Allison Thomas G. , Reid Christopher M. , Kirkpatrick James N. 
Published: November 2023

BackgroundInsufficient data exists regarding the relationship between body mass index (BMI) and the prognosis of chronic heart failure (CHF) specifically within low- and middle-income Asian countries. The objective of this study was to evaluate the impact of BMI on adverse outcomes of ambulatory patients with CHF in Vietnam.MethodsBetween 2018 and 2020, we prospectively enrolled consecutive outpatients with clinically stable CHF in an observational cohort, single-center study. The participants were stratified according to Asian-specific BMI thresholds. The relationships between BMI and adverse outcomes (all-cause death and all-cause hospitalization) were analyzed by Kaplan–Meier survival curves and Cox proportional-hazards model.ResultsAmong 320 participants (age 63.5 ± 13.3 years, 57.9% male), the median BMI was 21.4 kg/m2 (IQR 19.5–23.6), and 10.9% were underweight (BMI &lt;18.50 kg/m2). Over a median follow-up time of 32 months, the cumulative incidence of all-cause mortality and hospitalization were 5.6% and 19.1%, respectively. After multivariable adjustment, underweight patients had a significantly higher risk of all-cause mortality than patients with normal BMI (adjusted hazard ratios = 3.03 [95% CI: 1.07–8.55]). Lower BMI remained significantly associated with a worse prognosis when analyzed as a continuous variable (adjusted hazard ratios = 1.27 [95% CI: 1.03–1.55] per 1 kg/m2 decrease for all-cause mortality). However, BMI was not found to be significantly associated with the risk of all-cause hospitalization (p &gt; 0.05).ConclusionIn ambulatory patients with CHF in Vietnam, lower BMI, especially underweight status (BMI &lt; 18.5 kg/m2), was associated with a higher risk of all-cause mortality. These findings suggest that BMI should be considered for use in risk classification, and underweight patients should be managed by a team consisting of cardiologists, nutritionists, and geriatricians.
Non-therapeutic plasma levels in individuals utilizing curcumin supplements in daily life
Authors: Kroon Maurice A. G. M. , Berbee Jacqueline K. , Majait Soumia , Swart Eleonora L. , van Tellingen Olaf , van Laarhoven Hanneke W. M. , Kemper E. Marleen 
Published: November 2023

IntroductionThe spice curcumin and its metabolites are widely used by cancer patients but have not shown proven health benefits in clinical studies, likely due to low plasma concentrations after oral intake. However, public interest in curcumin continues to grow, and companies claim enhanced absorption in their formulations. This study aims to determine if daily oral intake of curcumin leads to sufficient plasma concentrations for health effects. The study was registered in the Dutch Clinical Trial Register with ID NL5931.MethodsWe used a validated HPLC-MS/MS method to measure curcumin and its metabolites in 47 individuals using their own curcumin formulations. Questionnaires assessed other supplement and medication use. Plasma samples were collected before and 1.5 h after intake, analyzing curcumin and metabolite levels with and without β-glucuronidase pretreatment to measure conjugated and unconjugated forms.ResultsPlasma concentrations of curcumin, demethoxycurcumin, bisdemethoxycurcumin and tetrahydrocurcumin, ranged between 1.0 and 18.6 ng/mL. Adding β-glucuronidase resulted in an increase of unconjugated curcumin plasma levels to 25.4 ng/mL; however still significantly below (1000-fold) a plasma concentration that is expected to have a beneficial health effect. The use of adjuvants like piperine did not result in higher curcumin plasma concentrations.DiscussionOur study shows that using oral curcumin supplements still does not result in therapeutic plasma levels. Health care practitioners need to be critical toward the claimed beneficial systemic health effects of current curcumin supplement use by their patients.Clinical Trial Registrationhttps://onderzoekmetmensen.nl/en/trial/25480, NL5931.
Doxorubicin impairs cognitive function by upregulating AMPAR and NMDAR subunit expression and increasing neuroinflammation, oxidative stress, and apoptosis in the brain
Authors: Alhowail Ahmad H. , Aldubayan Maha A. 
Published: November 2023

Introduction: The anticancer drug doxorubicin (DOX) is used for various malignancies. However, it also causes cognitive impairment in cancer survivors. In order to determine the mechanisms underlying the acute effects of DOX, we assessed the mRNA and protein expression of glutamate receptors and proteins involved in cognitive function and apoptosis.Methods: Fear-conditioning memory tests were performed in rats after a single intraperitoneal injection of DOX (25 mg/kg) to evaluate short-term memory function. Rat brain samples were collected, and GluA1 mRNA and protein expression; NR2A and NR2B mRNA expression; and COX-2, NF-kB, TNF-α, and MDA, Bax, and caspase-3 levels were assessed via reverse transcription polymerase chain reaction and enzyme-linked immunosorbent assays.Results: We observed a decreased number of entries in Y-maze, decreased exploration time to the novel object in the novel object recognition (NOR), and decreased freezing time in the fear-conditioning memory tests in DOX-treated rats relative to those in control rats, demonstrating cognitive impairment. GluA1, NR2B, and NR2A expression and MDA, NF-κB, Bax, COX-2, TNF-α, and caspase-3 levels in the brain were significantly elevated in DOX-treated rats.Conclusion: DOX induced cognitive impairment in the rats via neuronal toxicity by upregulating AMPAR and NMDAR expression and increasing neuroinflammation, oxidative stress, and apoptosis in the brain.
How do self-exempt beliefs affect intentions to quit smoking? An exploration of the mediating role of threat appraisal and coping appraisal
Authors: Zhang Dan , Liu Runhua , Li Xinchen , Yuan Yuanyuan , Zhou Geyao 
Published: November 2023

IntroductionNumerous smokers are cognizant of the detrimental effects associated with this habit yet exhibit a persistent reluctance to cease their tobacco consumption. Self-exempt beliefs serve as an obstacle to the cessation of this addictive behavior. This research explored the impact of self-exempt beliefs on the readiness to quit smoking based on the Protection Motivation Theory (PMT) model and the mediating roles of threat appraisal and coping appraisal.MethodsSelf-exempt beliefs, PMT constructs, and the intention to quit smoking constituted the theoretical model. The questionnaires were collected from 488 Chinese adult male smokers based on snowball sampling. Exploratory Factor Analysis (EFA) was used to examine the underlying factor structure of the pre-designed self-exempt beliefs scale. The reliability, validity, path coefficients, and explanatory power of the model were calculated using Partial Least Squares Structural Equation Modeling (PLS-SEM).Results and discussionThe results showed that : (1) three common factors (skeptic beliefs, bulletproof beliefs, and “worth it” beliefs) with a total of 11 items were retained after EFA; (2) skeptic beliefs and “worth it” beliefs had a significantly negative effect on both threat appraisal and coping appraisal, while bulletproof beliefs did not; (3) bulletproof beliefs had a significantly positive direct impact on intention to quit, “worth it” beliefs had a significantly negative direct impact on intention, while skeptic beliefs had no significantly direct impact on intention; (4) threat appraisal and coping appraisal positively and significantly predicted cessation intention; and (5) threat appraisal and coping appraisal, as two main cognitive processes, acted as full mediations between skeptic beliefs and the intention to quit, as complementary partial mediations between “worth it” beliefs and the intention, and as non-mediation between bulletproof beliefs and the intention. Our findings suggest that efforts to undermine or “prevent” these self-exempt beliefs, particularly “worth it” and skeptic beliefs, may be an effective tactic for health communication interventions for quitting smoking.
Healthcare bias and health inequalities towards displaced Syrians in Lebanon: a qualitative study
Authors: Khalifeh Riwa , D’Hoore William , Saliba Christiane , Salameh Pascale , Dauvrin Marie 
Published: November 2023

IntroductionAccording to Lebanese official data, Lebanon hosts over 1.5 million displaced Syrians (DS). Research shows that migrants encounter barriers when accessing healthcare. The social determinants of health (SDOH) related to migration are an additional challenge for DS in Lebanon, though bias plays a significant factor in exacerbating health inequalities. This study aims to identify DS perception of healthcare biases in the Lebanese healthcare system, and its consequences on DS’ accessing and receiving quality healthcare in Lebanon.MethodsA qualitative analysis using in-depth, semi-structured interviews was utilized. 28 semi-structured interviews were conducted with doctors (n = 12) and nurses (n = 16) in 2021. Six group interviews were conducted with DS (n = 22) in Lebanese healthcare facilities. The recruitment of participants relied on reasoned and targeted sampling. Thematic analysis was performed to identify common themes in participants’ experiences with DS accessing Lebanese healthcare.ResultsThe findings indicated that there were barriers to accessing healthcare related to the SDOH, such as transportation and financial resources. The results also suggested that DS perceived health biases, including discriminatory behavior from Lebanese healthcare providers, stereotypes and racism leading to health inequalities.ConclusionBased on the perceptions and experiences reported by participants, the underlying causes of biases are due to the fragility of the Lebanese healthcare system when facing a humanitarian crisis as well as a collapsing infrastructure torn by past wars and the current socio-political and financial crises in the country. Global initiatives are required to provide the necessary resources needed for offering equitable health services. Such initiatives involve addressing biases, health inequities, discrimination, and the lack of a Lebanese infrastructure system for the provision of healthcare. Addressing health inequalities remains a major health objective in achieving health equity on the micro level (cultural awareness and competencies) and macro level (equitable distribution of resources, implementation of a universal health coverage) in order to guarantee quality healthcare services to DS.
TEACHERS’ PERCEPTION TOWARDS ORGANIZATIONAL CLIMATE AT A BILINGUAL LANGUAGE PRIMARY SCHOOL IN ZHENGZHOU, CHINA
Authors: Lee Wei-Chi Wang , Ye Yan , Cheng Tze-Shang 
Published: November 2023

This study mainly aimed to identify the teachers’ demographic factors, to determine the level of teachers’ perception of the school climate, and to compare their perception according to their demographic factors including teachers’ gender, educational level, years of service, position. A total of 120 teachers from a private primary school in Zhengzhou were surveyed through questionnaire based on Tagurri’s (1968) school organizational climate theory.
The study found that the level of teachers’ perception of the school climate was “relatively high”. Though there was no significant difference in teachers’ perception towards school climate according to their gender at the selected school, significant differences in teachers’ perception towards school climate according to their educational levels, years of service and positions existed. Teachers with high educational levels had more positive perceptions towards the school climates at the selected school in Zhengzhou, China. Teachers with more than 15 years of service had the most positive perceptions towards the school climates at the selected school. Teachers with high administrative positions had more positive perceptions towards the school climates at the selected school in Zhengzhou, China.
PATHOMORPHOLOGICAL CHANGES IN THE KIDNEYS AND LIVERS OF RED-EARED SLIDER AFTER PARENTERAL ADMINISTRATION OF CEFTIFUR
Authors: Chuliuk V. I. 
Published: November 2023

Diseases of reptiles and the principles of their treatment are significantly different from the therapy of mammals and birds, which is primarily related to the anatomical and physiological features of representatives of this class of poikilothermic animals. In the complex treatment of infectious diseases of reptiles, a fairly effective antibiotic is ceftifur, which belongs to the third-generation cephalosporins, which are widely used in veterinary medicine.
To study the effect of cephalosporins on the body of reptiles, a histological and ultra-structural examination of the kidneys and liver of Red-eared slider (Trachemys scripta elegans) was performed, which were administered intramuscularly ceftifur (at a dose of 2.2 mg/kg) every 24 hours.
Experimental animals were removed from the experiment on the 7th day. Histological sections were made using a sledge microtome and cryostat microtome, stained with hematoxylin and eosin, Sudan III. Electron microscopic research was carried out using an electron microscope PEM-100-01.
As a result of the histological examination and transmission electron microscopy of the kidneys, dyscirculatory changes were revealed, characterized by the expansion and overflow of blood mainly in venous vessels, desquamation of endothelial cells in the vessel lumen, as well as dystrophic changes in the epithelium of the renal tubules. Structural changes in the epithelium of renal tubules were accompanied by damage to mitochondria, expansion of the tubules of the smooth endoplasmic reticulum and the accumulation of cytosomes, lysosomes, and autophagolysosomes in the cytoplasm. In the liver, a decrease in the density of melanomacrophage complexes was recorded, as well as a decrease in the number and change in the shape of fatty inclusions in the cytoplasm of hepatocytes, decrease in the number of glycogen granules. In necrotized hepatocytes, the nucleus underwent pyknotic changes, the cytoplasmic matrix brightened, and cytoplasmic organelles underwent destruction.
“PRÁTICAS PEDAGÓGICAS NO ENSINO DE CIÊNCIAS EM MEIO A PANDEMIA DO COVID-19”: UTILIZAÇÃO DE METODOLOGIAS ATIVAS NO ENSINO DE HISTÓRIA NATURAL
Authors: DO NASCIMENTO OUVERNEY THIAGO , DUTRA DOS SANTOS SAMPAIO ANA PAULA , PIRES CAMPOS CARLOS ROBERTO 
Published: November 2023

Este artigo tem como objetivo, discutir o uso das metodologias ativas através das ferramentas disponíveis pela plataforma Google for education, no ensino de ciências em meio a pandemia do coronavírus. A partir de atividades propostas através do Google Forms, com inserção de imagens e vídeos, pretende-se que os estudantes passem de simples memorizadores de conteúdos, garantindo autonomia e interação com as ferramentas tecnológicas. O projeto foi desenvolvido com alunos do 6º ano do Ensino Fundamental de uma escola estadual do município da Viana, e envolveu a construção de formulários do Google, ao alcance de alunos e famílias, na utilização das ferramentas tecnológicas, a fim de minimizar os impactos provocados pela pandemia no processo de aprendizagem. Pretende-se que esta prática sirva de exemplo para outros professores, visto o caráter emergencial do momento, que exige um reinventar da educação e de nossas práticas pedagógicas, podendo então ser replicada em diversas disciplinas.
EFEKTIVITAS POLA KOMUNIKASI PENYULUH PERTANIAN TERHADAP PENGEMBANGAN KELOMPOK TANI KOPI DESA TENGKU MANGGARAI BARAT
Authors: Jandu Inosensius , Bahal Robertus , Cordanis Astrid Priscilla 
Published: November 2023

Penelitiana ini dilatarbelakangi bagaimana penggunaan pola komunikasi dan efektivitas pola komunikasi yang digunakan penyuluh pertanian di Desa Tengku. Tujuan yang dicapai dalam penelitian ini yakni: Mengetahui pola komunikasi yang digunakan oleh penyuluh pertanian Desa Tengku. Mengetahui efektivitas pola komunikasi yang digunkan penyuluh pertanian Desa Tengku. Jenis penelitian ini adalah penelitian deskriptif kualitatif. Hasil penelitian menunjukan pola komunikasi satu arah, penyuluh menyampaikan pesannya secara langsung bertatap muka dimana petani hanya sebagai pendengar saja tanpa ada umpan balik dalam melaksanakan diskusi. Pola komunikasi dua arah penyuluh dan petaniÂ akan saling berdiskusi apabila ada kendala maupun hambatan dalam berusaha tani. Pola komunikasi multi arah dimana petani dan penyuluh akan saling bertukar pikiran atau diskusi dalam kegiatan berlangsung baik dengan penyuluh maupun dengan sesama petani. Sedangkan efektivitas pola komunikasi penyuluh pertanian yaitu pola komunikasi satu arah dimana petani hanya sebagai pendengar saja tanpa ada umpan balik dalam melaksanakan komunikasi. Pola komunikasi dua arah dimana petani dan penyuluh akan saling bertukar pikiran dalam kegiatan penyuluhan berlangsung. Pola komunikasi multi arah sangat efektif karena dalam perkumpulan kelompok tani, penyuluh membuka pikiran petani dalam diskusi kelompok. Ketika ada masalah maka dapat didiskusikan bersama dan menghasilkan solusi yang terbaik.
EFEKTIVITAS PENGGUNAAN SELFTALK DALAM PEMBELAJARAN PENJAS BAGI SISWA ( SYSTEMATIC LITERATURE REVIEW )
Authors: Syafawani Nindiya , Rahmat Alit , Carsiwan Carsiwan 
Published: November 2023

EFEKTIVITAS PENGGUNAAN SELFTALK DALAM PEMBELAJARAN PENJAS BAGI SISWA ( SYSTEMATIC LITERATURE REVIEW )Selftalk memiliki peranan sebagai motivasi agar siswa mampu membuat dirinya kembali semangat atau memiliki dorongan untuk meningkatkan kemampuannya melalui rasa percaya diri, bahwa dirinya mampu dan bisa mengatasi rasa cemas yang dirasakannya. Penelitian ini bertujuan untuk mengetahui keefektifan penggunaan self talk pada pendidikan jasmani siswa, hal ini disebabkan karena kurangnya motivasi dan rasa percaya diri siswa dalam melakukan suatu kegiatan. Oleh karena itu, self talk merupakan salah satu cara untuk membantu siswa agar memiliki tingkat kepercayaan diri yang lebih baik. Metode penelitian yang digunakan adalah Systematic Literature Review. Pencarian literatur menggunakan database dari Google Schoolar. Penelusuran literatur dibatasi pada kriteria dan tahun yang telah ditentukan serta dipublikasikan pada jurnal nasional/internasional yang terindeks dan terakreditasi. Berdasarkan hasil penelitian yang telah dilakukan, disimpulkan bahwa Selftalk dapat meningkatkan rasa percaya diri dan kesehatan mental siswa. Self talk mempunyai peranan penting dalam olahraga karena dapat digunakan untuk membantu mengendalikan pikiran dan perasaan baik sebelum pertandingan, maupun pada saat pertandingan dan kegiatan lain yang dilakukanÂ diÂ sekolah.
Adawātu Al-Syart Ghairu Al-Jāzimah Fī Sūrah Ali Imrān (Dirāsah Nahwiyyah Tahlīliyyah)
Authors: Mahmudi Muhlish , Khanif Muhammad 
Published: November 2023

تهدف هذه الدراسة إلى التعرف على الآيات المتضمنة أدوات الشرط غير الجازمة في سورة آل عمران، ومعرفة أداة الشرط وفعله وجوابه في كل آية من تلك الآيات، وقد قام الباحث بهذه الدراسة نظرا إلى أهمية دراسة هذه الأدوات؛ حيث إنها من الأدوات الشائعة التي تكررت كثيرا في الكلام عامة وفي القرآن الكريم خاصة. سلك الباحث لهذه الدراسة المنهج الوصفي التحليلي. وأثبتت الدراسة أن أدوات الشرط غير الجازمة التي وردت في سورة آل عمران هي 5 أداوات "لو" و"أمّا" و"لـمّا" و"إذا" و"كلّما"، وهن واردة في 18 آية من 200 آية، وبالتفصيل: أداة "لو" ترد 7 مرات في 6 آيات مختلفة، وأما أداة "أمّا" فهي ترد 5 مرات في 5 آيات مختلفة، وأما أداة "لـمّا" فهي ترد 3 مرات في 3 آيات مختلفة، وأما أداة "إذا" فهي ترد 5 مرات في 4 آيات مختلفة، وأما أداة "كلّما" فهي ترد مرة واحدة فقط
This study aims to identify the verses containing the Adawātu al-syart in Sūrat Ali Imrān, and to know the adatu al-syart and fi’lu al-syart and jawābu al-syart in all verses, and the researcher carried out this study due to the importance of studying these tools, since they are common tools that are frequently repeated in the speech in general and in the Qur'an in particular. The researcher took this study the descriptive analytical approach. The study proved that the adawatu al-syart in Surat Ali Imran are 5 adawat "لو", "أمّا", "لمّا", "إذا" and "كلّما", and they are contained in 18 verses of 200 verses, in detail: "لو" is contained 7 times in 6 different verses, the "أمّا" is contained 5 times in 5 different verses, the "لمّا" is contained 3 times in 3 different verses, the "إذا" is contained 5 times in 4 different verses, and the tool "كلّما" is contained only once.
Penelitian ini bertujuan untuk mengidentifikasi ayat-ayat yang mengandung adawatu al-syart ghairu al-jazimah dalam Surat Ali Imran dan untuk mengetahui adatu al-syart dan fi’lu al-syart dan jawabu al-syart pada masing-masing ayat tersebut, peneliti melakukan penelitian ini karena pentingnya ilmu ini, karena adawaru al-syart termasuk adawat yang sering terulang dalam pembicaraan secara umum dan dalam Al-Qur'an pada khususnya. Pada penelitian ini peneliti menggunakan pendekatan analisis deskriptif. Penelitian ini menetapkan hasil bahwa adawatu al-syart ghairu al-jazimah yang terkandung dalam Surat Ali Imran adalah 5 adawat "لو", "أمّا", "لمّا", "إذا" dan "كلّما", dan adawat tersebut terkandung dalam 18 ayat dari 200 ayat, secara rinci: "لو" terkandung 7 kali dalam 6 ayat yang berbeda, "أمّا" terkandung 5 kali dalam 5 ayat yang berbeda, "لمّا" terkandung 3 kali dalam 3 ayat yang berbeda, "إذا" terkandung 5 kali dalam 4 ayat yang berbeda, dan "كلّما" hanya disebutkan sekali.