bluuebunny/crossref_metadata_2025_split huggingface dataset:
Risk of severe case in COVID-19 patients and Azvudine: A Retrospective cohort study after exit from ‘zero-COVID’ policy
Authors: Li Lishan , Li Li , Ye Lihua , Lu Baijie , Wang Jieling , Wei Guanhua , Bian Zhuang 
Published: January 2024

Abstract

Background COVID-19 leaded to significant morbidity and mortality. To investigate contributing factors to severity and examine whether Azvudine can reduce mortality, we conducted a single-center, retrospective cohort study.Method 4201 COVID-19 patients discharged from our hospital were enrolled. Logistic regression analysis and ROC curve were used to investigate the role of comorbidities, laboratory parameters and clinical manifestation on progression of COVID-19. Propensity-score models conditional on baseline characteristics and Univariate Cox regression model were used to examine whether Azvudine can reduce the mortality of COVID-19.Result Age, male sex, cerebrovascular disease, chronic kidney disease, liver disease, tumor and chronic lung disease were associated with elevated risk of mortality and chronic kidney disease contributed the most risk. Uric acid showed a U-shape risk of severity. Both hyperuricemia and hypouricemia increased the risk of severity. D-dimer, NT-BNP, LDH and FT3 were the most sensitive and specific markers for the prediction of mortality. Poor appetite, consciousness deterioration, polypnea and persistent high fever were associated with elevated risk of severity. Compared with no antiviral group, Azvudine can reduce the COVID-19 mortality (hazard ratio 0.708(95% confidence interval 0.516 to 0.971), P = 0.032. There was no significant difference in mortality reduction between Molnupiravir and Azvudine(P = 0.486).Conclusions Among COVID-19 patients, age, male sex and comorbidities can affect progression of COVID-19. D-dimer, NT-BNP, LDH, FT3, UA, poor appetite, consciousness deterioration, polypnea and persistent high fever can help doctors predict severe illness. Azvudine is neck and neck with Molnupiravir in the mortality reduction among COIVD-19.
Exploring Ecologically-Friendly Urbanization: The Impact of Physical Activity on Achievement Emotions and Academic Performance among Jiangsu Higher Vocational College Students
Authors: Shang Yanfeng , Shang Yanxia , Keat Ooi Boon 
Published: January 2024

Abstract
The study closely relates to the experiences of students at Jiangsu Higher Vocational College. These young individuals, who represent the process of urbanization in many countries, deal with the difficulties and advantages that come with modern urban living. Within the context of the fast-paced urban development in Jiangsu Province, students encounter a multifaceted combination of academic stress, city life, and emotional welfare. The importance of physical activity in enhancing cognitive function, academic performance, and emotional balance is strongly felt within this group, reflecting the worldwide discussion on the connection between exercise, academic success, and emotional well-being. Our systematic study aimed to investigate the complex relationships between physical activity, academic achievement, and emotional well-being, focusing primarily on students enrolled at Jiangsu Higher Vocational College. Upon analyzing previous studies conducted till early 2009, our research uncovered limited but favorable correlations between physical activity/fitness and academic achievement. This highlights the need for customized treatments and more investigation targeted at this particular set of students. This research highlights the significant knowledge gap about the intricate relationship between physical activity, cognitive function, and academic outcomes specific to urban adolescents, despite the absence of definitive data. Our findings support the need for detailed and thorough studies that explore the complex connections between physical exercise, emotional well-being, and academic success, with a special focus on the urbanization environment of Jiangsu. Gaining a comprehensive understanding of these processes is crucial in promoting an environmentally sustainable urban setting that facilitates both academic achievement and emotional well-being among the students at Jiangsu Higher Vocational College.
Single dose of peg GCSF compared with daily GCSF in de novo acute myeloid leukemia patients on high dose cytarabine consolidation chemotherapy (HIDAC)
Authors:   1.	Bilal Kazi,   2.	Prakas Kumar Mandal,   3. Sumit Mitra,   4.	Imaan Rumani,   5.	Soma Mandal,   6.	Tuphan Kanti Dolai, Ghosh Reshma 
Published: January 2024

Abstract

Background: Consolidation therapy with high dose cytarabine (HIDAC) for Acute Myeloid Leukemia (AML)is associated with significant neutropenia , resultant infections and associated morbidities. In this prospective study on de novo AML patients we attempted to compare efficacy of peg GCSF vs GCSF in ameliorating the duration and severity of neutropenia.
Material and methods: Fifty eight cycles of HIDAC(1,3,5) from 20 patients were studied. Twenty four hours after the consolidation chemotherapy, patients were randomized to receive either once daily short-acting GCSF (5 µg/kg) or single dose of long acting peg GCSF(6mg/100 µg per kg).
Results: The median duration of neutropenia and episodes of febrile neutropenia were 9.0 and 15 in the GCSF arm and 9.8 days and 17 in the peg GCSF arm, respectively (p >0.05).. Incidence of positive microbiological cultures and mean duration of hospital stay was similar in the two arms.
Conclusion: The results of this study failed to show any difference in the incidence and duration of febrile neutropenia, incidence of infections and associated morbidities, with the use of GCSF compared to peg GCSF in patients of AML on HIDAC consolidation therapy.
Role of aldosterone in various target organ damage in patients with hypertensive emergency: A cross-sectional study
Authors: Suzuki Toshihiko , Miyake Akihiro , Endo Keita , Hayashi Koichi , Hirai Taro , Hara Yuki , Takano Keisuke , Horikawa Takehiro , Yoshino Kaede , Sakai Masahiro , Kitamura Koichi , Ito Shinsuke , Imai Naohiko , Fujitani Shigeki 
Published: January 2024

Abstract
Hypertensive emergency is a critical disease that causes multiple organ injuries. Although the renin-angiotensin-aldosterone system (RAS) is enormously activated in this disorder, whether the RAS contributes to the development of the organ damage has not been fully elucidated. This cross-sectional study was conducted to characterize the association between RAS and the organ damage in patients with hypertensive emergencies. We enrolled 54 patients who visited our medical center with acute severe hypertension and multiple organ damage between 2012 and 2020. Upon admission, the hypertensive damage was evaluated, including severe kidney impairment (eGFR less than 30 mL/min/1.73 m2, SKI), severe retinopathy, concentric left ventricular hypertrophy (c-LVH), thrombotic microangiopathy (TMA) and heart failure with reduced ejection fraction (HFrEF). Among 54 patients, 30, 34 and 37 cases manifested SKI, severe retinopathy and c-LVH, respectively. Each population with these organ injuries had higher plasma aldosterone concentrations than the remaining subset but exhibited variable difference in systolic or diastolic blood pressure. Twenty-two patients had a triad of SKI, severe retinopathy and c-LVH, among whom 5 patients manifested TMA. Furthermore, the number of the damaged organs was correlated with plasma aldosterone levels (Spearman’s coefficient=0.47), with a strong association between plasma aldosterone (≥250 pg/mL) and 3 or more complications (odds ratio=8.49 [95%CI: 2.37-30.46]). In conclusion, in patients with hypertensive emergencies, a higher aldosterone level not only contributed to the development of the organ damage but also was associated with the number of damaged organs in each patient.
Chip collection of hepatocellular carcinoma based on O2 heterogeneity from patient tissue
Authors: Sung Hak-Joon , Baek Sewoom , Ha Hyun-Su , Park Jeong Su , Kim Hye-Seon , Chung Seyong , Kim Chansik , Kim Jueun , Kim Hyunjae , Yu Seung Eun , Cho Sungwoo , Yoon Ja Kyung , Choi Jin Sub , Han Dai Hoon , Lee Kyubae , Nam Yujin 
Published: January 2024

Abstract

As hepatocellular carcinoma (HCC) recurs even after surgical operation, tumor avatar models have been suggested to approach the HCC type-specified clinical strategy. However, unlike other cancer environments, the dual supply from hepatic artery and vein drives the inherent heterogeneity in HCC characteristics with adaptation to the location-dependent oxygen concentration. This characteristic heterogeneity results in low success rate and lengthy process in producing the HCC avatar models. Here, these HCCs are separated and collected following the incremental and decremental oxygen concentrations in a chip by directly culturing tissues from 12 patients. The media perfusion with drug was set up in the perpendicular direction to the oxygen gradient, thereby examining drug responsiveness simultaneously with the HCC separation in the dual gradient fashions. The chip results are cross-validated in mice by modifying the PDX model to implant the same tissue-containing chips into normoxic normal limb, sub-hypoxic subcutaneous spot, and hypoxic ischemic hindlimb. In both chip and mice, the hypoxia-side HCCs exhibit most invasive and recurrent characteristics as confirmed by molecular expression, cell migration, and drug resistance in alignment with the clinical outcomes. The chip serves as a promising means to predict the treatment prognosis by identifying the dominant HCC type in each patient.
Safety and efficacy of a evidence-based nursing practice on early mobilization after surgery for glioma: a historical control study
Authors: Chen Xiaohang , Ye Qifa , Wan Lei , Wu Zhishui , He Chongxiang , Wang Bei 
Published: January 2024

Abstract
Early mobility has been proven to accelerate postoperative recovery in patients, but they have not yet been widely used in postoperative glioblastoma patients. The evidence-based nursing method was used to obtain clinical practice evidence. A standardized nursing care process for patients after surgery was developed which corresponds to different early mobilization plans for patients with different muscle strength and at different postoperative times. This plan Firstly, standardized training and examination were provided to department nurses (n = 48). Then the experimental group (n = 59) was subjected to the early mobilization rehabilitation nursing program plus routine nursing care, whereas the observation (n = 56) received only routine nursing care. The nurses reported that their awareness rate and passing rate on early mobilization health education improved substantially after the training program. Significant statistical differences were found in patients’ score of ADL, the first time of getting out of bed, the time of indwelling catheter, gastric tube, the central venous catheter, hospitalization time, and postoperative complications (P < 0.05). The rehabilitation of postoperative patients with glioma cancer who used evidence-based early mobilization health education is safe and reliable after craniotomy, which promotes the recovery of patients. Clinical trial registration: Our ethical approval has been approved by the Medical Ethics Committee of Zhongnan Hospital of Wuhan University. The ethical approval number is 2019258, and we are currently unable to provide a Clinical Trial registration number.
Feasibility and clinical value of linear endoscopic ultrasonography in the lower gastrointestinal subepithelial lesions
Authors: Tao Li , Chen Yajun , Fang Qianqian , Xu Fan , Yu Qianwei , Zhang Lijiu , Hu Xiangpeng 
Published: January 2024

Abstract
Linear endoscopic ultrasonography (EUS) has been extensively utilized as a novel diagnostic and therapeutic modality across various fields. However, there have been relatively few studies focusing on lower gastrointestinal lesions. The aim of our study was to investigate the feasibility, safety and clinical value of linear EUS in the lower gastrointestinal subepithelial lesions. This was a retrospective study involving patients with lower gastrointestinal subepithelial lesions diagnosed by linear EUS from August 2019 to April 2023 at the Second Affiliated Hospital of Anhui Medical University. The data, including basic clinical information, linear EUS features, technical success rate, complications, and follow-up, were retrospectively collected and analyzed. A total of 69 patients with lower gastrointestinal subepithelial lesions underwent examination by linear EUS. Excluding the rectum, the technical success rate of linear EUS was 90.6% (29/32). Apart from the 7 patients whose diagnosis remained unknown, 3 patients with no abnormal EUS findings, and 3 patients failed the procedure, 56 patients were included in the final diagnostic performance analysis. The most common locations of the lesions were the rectum (37/56, 66.1%) and sigmoid colon (7/56, 12.5%). Based on endoscopy findings and pathological results, the most prevalent types of subepithelial lesions in the lower gastrointestinal tract were neuroendocrine tumor (NET) (12/56, 20.3%), lipoma (8/56, 13.6%) and extraluminal compression (8/56, 13.6%). The majority of lesions ranged in diameter from 1 to 3 cm (χ2 = 18.750, p < 0.001). After undergoing linear EUS examination, 36 patients received EUS-FNA (3/36), biopsy (5/36), endoscopic resection (25/36), or surgical excision (3/36) respectively. The pathological results of 29 patients were entirely consistent with the diagnosis made using linear EUS, with an 80.6% (29/36) diagnostic accuracy rate. Follow-up indicated that the lesions remained unchanged within 6-36 months. All patients tolerated the procedure well without any complications. In conclusion, linear EUS demonstrates technical feasibility, safety, and a high diagnostic accuracy for subepithelial lesions in the lower gastrointestinal tract.
Process evaluation of Project Daire: a food environment intervention that impacted food knowledge, wellbeing and dietary habits of primary school children
Authors: Anderson Naomi , Brennan Sarah F. , Lavelle Fiona , Moore Sarah E. , Olgacher Dilara , Junkin Amy , Dean Moira , McKinley Michelle C. , McCole Patrick , Hunter Ruth F. , Dunne Laura , O’Connell Niamh E. , Elliott Chris T. , McCarthy Danielle , Woodside Jayne V. 
Published: January 2024

Abstract

Background: The Project DAIRE trial aimed to improve children’s health-related quality of life, wellbeing, food knowledge and dietary habits via two multi-component interventions: Nourish, and Engage. Nourish was an intervention aiming to alter the school food environment, provide food-based experiences and expose pupils to locally produced foods. Engage was an age-appropriate cross-curricular food education intervention incorporating food, agriculture, nutrition science and related careers. The purpose of this study was to conduct a mixed methods process evaluation to evaluate DAIRE implementation, mechanisms of impact (MOI) and context, and inform scalable implementation of the DAIRE approach.
Methods: The Medical Research Council’s (MRC) framework for process evaluation was followed. Formal and informal methods were used to collect quantitative and qualitative data during the DAIRE trial in relation to process evaluation. Quantitative data were analysed using descriptive statistics and qualitative data via thematic analysis to identify key themes.
Results: Fifteen schools and 983 pupils (n=495 Key Stage 1 (KS1) and n=488 Key Stage 2 (KS2) pupils) were recruited for the 6-month DAIRE intervention; a 100% retention rate was observed at the school level and the interventions had a high level of acceptability. Nourish schools implemented a higher mean intervention dose (57.2%) than Engage (50%) schools but, overall, mixed implementation of both interventions occurred. DAIRE produced change through four key MOI: social learning, experimental learning, interactive engaging content and real-life connections. Lack of time was the main contextual barrier to DAIRE implementation and lack of financial cost to schools was indicated as a potential facilitator.
Conclusions: This process evaluation helped to identify important findings related to implementation, MOI and context. The most effective elements of the interventions which should be maintained include provision of interactive and engaging intervention elements and ensure these are at no financial cost to the school. Findings also identified suggestions for improvement including provision of increased teacher training, support and planning time, content reduction to facilitate easy integration into the school curriculum, and implementation across the full academic year. A sustainable funding and resourcing mechanism is required for successful future roll-out.
Trial Registration: The original trial referenced in this process evaluation is registered as follows: National Institute of Health (NIH) U.S. National Library of Medicine Clinical Trials.gov (ID: NCT04277312)
Investigating the Relationship between Missed/Rationed Nursing Care and Organizational Commitment in Nurses
Authors: Babaei Faranak , Nayeri Nahid Dehghan , Hajibabaee Fatemeh , Sharifi Farshad 
Published: January 2024

Abstract

Background
The primary objective of the nursing profession is to deliver comprehensive and suitable nursing care that aligns with the individual requirements of patients. However, instances of missed/rationed nursing care can jeopardize the provision of complete and secure healthcare, potentially endangering patients' lives. The level of organizational commitment demonstrated by nurses is likely to impact several individual and organizational factors. This study examines the relationship between missed/rationed care and organizational commitment.
Methods
This is a descriptive and cross-sectional study and 300 nurses working in general and intensive critical care units of Tehran University of Medical Sciences hospitals were randomly selected in 2023. Data collection included Allen and Mayer's organizational commitment questionnaires, Kalish's missed care questionnaire, and demographic variables. A multiple linear regression model was used to analyze the prediction of missed care by commitment and other variables.
Results
Half of the nurses reported occasionally missing nursing care. Additionally, more than half of the nurses reported moderate organizational commitment in all dimensions. The most significant reasons identified by nurses for missed care were financial resources, human resources, and communication (p < 0.001). There was a significant relationship between missed/rationed nursing care and organizational commitment (p = 0.042). In the multiple regression equation, a significant portion of missed care due to commitment was predicted when considering demographic variables (p < 0.001).
Conclusions
Managers should prioritize addressing missed/rationed care to minimize its occurrence and improve healthcare quality, thereby preventing associated costs and consequences. Nursing managers should implement strategies to improve nurses' commitment status, reduce turnover rates, and enhance the quality of nursing care.
Soil Physiochemical Properties and Cucumber Productivity Assessment under Organic Fertilization
Authors: Agbor David Tavi , Egbe Leonel Enow , Tambe Agborante Agbor , Sama Desmond Kwayela , Lekelefeh Bezua Collins , Tabot Pascal Tabi , Mfombep Priscilla Mebong 
Published: January 2024

Abstract

Given the global increase in cucumber production due to its nutritional quality, high health risks are associated with cucumber consumption due to contamination by phytotoxic heavy metals resulting from synthetic fertilizers. Thus, producing contaminants-free cucumber fruits warrants the employment of eco-friendly fertilizers sources. This study, conducted in Kumba, Cameroon, explores the impact of organic manures; poultry droppings, cow dung, and cocoa pod husks, on organic cucumber cultivation and their effects on soil properties. The experiment, spanning the 2019 and 2020 growing seasons, employed a three-repeated randomized complete block design with four treatments: control, poultry droppings, cow dung, and cocoa pod husks. Results indicated a significant enhancement (P = .05) in soil fertility attributed to increased OC, OM, exchangeable Ca, K, Mg, Ntot, and Pavail, with poultry droppings exhibiting the most substantial impact. This improvement in soil quality translated into notable growth parameters for cucumbers. Poultry droppings resulted in the highest vine length (168 cm), leaf number (25), and branch number (12), while the control exhibited the lowest values. Cucumber yield significantly increased with poultry droppings leading (11.3 t/ha) and the control trailing (5.5 t/ha). Cucumber fruit length was influenced by the treatments, with the longest in poultry droppings (20 cm) and the shortest in the control (12 cm). Strong correlations were observed between cucumber yield and total nitrogen (r = 0.98995), available phosphorus (r = 0.99393), and potassium (r = 0.84688). Overall, the incorporation of organic manures, particularly poultry droppings, enhanced soil fertility, and boosted cucumber production.
Outcomes of Surgical vs. Conservative Management of Pediatric Acute Appendicitis in an Israeli Level 1 Surgical Center: A Retrospective Study
Authors: Romach Tal , Cohen Neta , Fuhrer Audelia Eshel , Rimon Ayelet , Capua Tali 
Published: January 2024

Abstract
Background: Acute appendicitis (AA) is a common pediatric surgical emergency with considerable financial implications. Data on the comparative outcomes of surgical and conservative management approaches and their impact on healthcare resources are limited.
Objectives: This retrospective study aimed to compare surgical and conservative management outcomes of AA in an Israeli level 1 surgical center, focusing upon length of pediatric emergency department (PED) stay, hospital stay, revisit and readmission rates, and rates of eventual surgical intervention. The number of sick days needed by the child and caregiver during the first year post-diagnosis was also quantified.
Methods: Consecutive pediatric patients (<18 years of age) diagnosed with AA in our PED between August 2016 and February 2022 were included. Data on demographics, clinical examinations, outcomes, and resource utilization were collected. Patients with complicated appendicitis or severe chronic diseases were excluded.
Results: The 418 suitable patients were divided between 86 in the conservative management group and 332 in the surgical management group. Conservatively managed patients had longer-lasting PED visits, more PED revisits, more readmissions, and more ambulatory visits, resulting in more "sick days". Fifty (58%) of them eventually required surgery. Age ≥11 years emerged as an independent predictor for conservative treatment failure.
Conclusion: Conservative management of AA imposed a greater burden on PED resources. Despite similar initial lengths of PED stays, conservatively managed children had more numerous and longer-lasting readmissions. Surgical management was associated with relatively more favorable outcomes, reduction in healthcare resources utilization, and lower treatment failure rates. Age >11 years emerged as a predictor for conservative treatment failure. These findings warrant larger-scale studies to enhance treatment strategies and use of healthcare resources for children with AA. Hospital policies should take this data into account when deciding on protocols for appendicitis treatment.