bluuebunny/crossref_metadata_2025_split huggingface dataset:
Long-term disease-free survival following comprehensive involved site radiotherapy for oligometastases
Authors: Kao Johnny , Sahagian Michelle , Gupta Vani , Missios Symeon , Sangal Ashish 
Published: December 2023

IntroductionDespite recent advances in drug development, durable complete remissions with systemic therapy alone for metastatic cancers remain infrequent. With the development of advanced radiation technologies capable of selectively sparing normal tissues, patients with oligometastases are often amenable to comprehensive involved site radiotherapy with curative intent. This study reports the long-term outcomes and patterns of failure for patients treated with total metastatic ablation often in combination with systemic therapy.Materials and methodsConsecutive adult patients with oligometastases from solid tumor malignancy treated by a single high volume radiation oncologist between 2014 and 2021 were retrospectively analyzed. Oligometastases were defined as 5 or fewer metastatic lesions where all sites of active disease are amenable to local treatment. Comprehensive involved site radiotherapy consisted of stereotactic radiotherapy to a median dose of 27 Gy in 3 fractions and intensity modulated radiation therapy to a median dose of 50 Gy in 15 fractions. This study analyzed overall survival, progression-free survival, patterns of failure and toxicity.ResultsA total of 130 patients with 209 treated distant metastases were treated with a median follow-up of 36 months. The 4-year overall survival, progression-free survival, local control and distant control was 41%, 23%, 86% and 29%. Patterns of failure include 23% alive and free of disease (NED), 52% distant failure only, 9% NED but death from comorbid illness, 7% both local and distant failure, 4% NED but lost to follow-up, 4% referred to hospice before restaging, 1% local only failure, 1% alive with second primary cancer. Late grade 3+ toxicities occurred in 4% of patients, most commonly radionecrosis.ConclusionInvolved site radiotherapy to all areas of known disease can safely achieve durable complete remissions in patients with oligometastases treated in the real world setting. Distant failures account for the majority of treatment failures and isolated local failures are exceedingly uncommon. Oligometastases represents a promising setting to investigate novel therapeutics targeting minimal residual disease.
A cross-sectional study of appropriateness evaluation of anticoagulation therapy for inpatients with nonvalvular atrial fibrillation
Authors: Zheng Xiao-Yuan , Feng Guang-Wei , Guo Jing , Xie Fen , Li Xia , Zhang Ming-Zhu , Zhang Xiu-Fen , Wu Xiu-Feng , Ding Yong-Juan 
Published: December 2023

Background: Oral anticoagulants (OACs) are essential for stroke prevention in patients with nonvalvular atrial fibrillation (NVAF). However, the appropriateness of anticoagulation treatment in locally practice remains unclear. This study evaluated compliance with anticoagulation therapy concerning the guidelines and drug labels in patients with NVAF.Methods: Hospitalized patients diagnosed with NVAF between 1 November 2020, and 31 December 2021, were retrospectively enrolled. The appropriateness of anticoagulation regimens at discharge was evaluated based on a flowchart designed according to atrial fibrillation (AF) guidelines and medication labels. Furthermore, we explored factors potentially influencing the “no-use of OACs” using binary logistic regression and verified anticoagulation-related issues through a physician questionnaire.Results: A total of 536 patients were enrolled in this study, including 254 patients (47.4%) with inappropriate anticoagulation regimens. 112 patients (20.9%) were categorized as “underdosing-use of OACs,” 134 (25%) who needed anticoagulation therapy were “no-use of OACs” and eight (1.5%) were “over-use of OACs.” The results of a binary logistic regression analysis showed that paroxysmal AF (odds ratio [OR], 7.74; 95% confidence interval [CI], 4.57–13.10), increased blood creatinine levels (OR, 1.88; 95% CI, 1.11–3.16), hospitalized pacemaker implantation (OR, 6.76; 95% CI, 2.67–17.11), percutaneous coronary intervention (OR, 3.35; 95% CI, 1.44–7.80), and an increased HAS-BLED score (OR, 1.62; 95% CI, 1.11–2.35) were associated with “no-use of OACs” in patients with NVAF who had indications for anticoagulation therapy.Conclusion: For patients with NVAF with severe renal dysfunction and paroxysmal AF, anticoagulation therapy was inadequate. The underdosing-use of OACs in patients with NVAF was frequently observed. We recommend an anticoagulation management team to tailor anticoagulation regimens to suit each patient’s needs.
Brief isoflurane administration as an adjunct treatment to control organophosphate-induced convulsions and neuropathology
Authors: Puthillathu Narayanan , Moffett John R. , Korotcov Alexandru , Bosomtwi Asamoah , Vengilote Ranjini , Krishnan Jishnu K. S. , Johnson Erik A. , Arun Peethambaran , Namboodiri Aryan M. 
Published: December 2023

Organophosphate-based chemical agents (OP), including nerve agents and certain pesticides such as paraoxon, are potent acetylcholinesterase inhibitors that cause severe convulsions and seizures, leading to permanent central nervous system (CNS) damage if not treated promptly. The current treatment regimen for OP poisoning is intramuscular injection of atropine sulfate with an oxime such as pralidoxime (2-PAM) to mitigate cholinergic over-activation of the somatic musculature and autonomic nervous system. This treatment does not provide protection against CNS cholinergic overactivation and therefore convulsions require additional medication. Benzodiazepines are the currently accepted treatment for OP-induced convulsions, but the convulsions become refractory to these GABAA agonists and repeated dosing has diminishing effectiveness. As such, adjunct anticonvulsant treatments are needed to provide improved protection against recurrent and prolonged convulsions and the associated excitotoxic CNS damage that results from them. Previously we have shown that brief, 4-min administration of 3%–5% isoflurane in 100% oxygen has profound anticonvulsant and CNS protective effects when administered 30 min after a lethal dose of paraoxon. In this report we provide an extended time course of the effectiveness of 5% isoflurane delivered for 5 min, ranging from 60 to 180 min after a lethal dose of paraoxon in rats. We observed substantial effectiveness in preventing neuronal loss as shown by Fluoro-Jade B staining when isoflurane was administered 1 h after paraoxon, with diminishing effectiveness at 90, 120 and 180 min. In vivo magnetic resonance imaging (MRI) derived T2 and mean diffusivity (MD) values showed that 5-min isoflurane administration at a concentration of 5% prevents brain edema and tissue damage when administered 1 h after a lethal dose of paraoxon. We also observed reduced astrogliosis as shown by GFAP immunohistochemistry. Studies with continuous EEG monitoring are ongoing to demonstrate effectiveness in animal models of soman poisoning.
The impact of videogames on the mood of amateur youth players during consecutive games
Authors: Mateo-Orcajada Adrián , Vaquero-Cristóbal Raquel , Gallardo-Guerrero Ana María , Abenza-Cano Lucía 
Published: December 2023

IntroductionEsports have experienced tremendous growth in recent years. In the scientific field, previous research has shown the determining role of psychology in competitive performance, but little is known about the factors that may be more determinant. In addition, in the amateur field, where fun and enjoyment are the most important factors, it has been observed that players can see their psychological state altered due to different factors, but it is not known if the outcome of the game (win or lose) can be influential. For this reason, the aim of the present investigation was to analyze changes in players' mood between three consecutive games as a function of the outcome of each game.MethodsA total of 14 amateur players participated in the research, all of them with previous experience and being regular League of Legends players. The participants completed the POMS questionnaire before the start of each game and the outcome of each game was recorded at the end.ResultsThe results showed that no significant pre-game differences were found in any of the games, regardless of winning or losing. Significant differences were found in the pre-game mood between the first and second game, according to the outcome of the first game, and between the second and third game, according to the outcome of the second game. Between the first and second games, there was a significant increase in depression (p = 0.038) and anger (p = 0.003) when the first game was lost; and between the second and third games, there was a decrease in tension (p = 0.003) and anger (p = 0.022) when the second game was won. In addition, it should be noted that fatigue increased significantly after each game, regardless of the outcome, and with respect to the change in mood, this was more noticeable when the first game was lost and the second was won, as significant changes were observed in tension (p = 0.028), depression (p = 0.030) and anger (p = 0.006).ConclusionPre-match mood does not influence post-match performance, but mood changes do occur between successive matches depending on the outcome of the match.
The Stilbene Synthase Family in Arachis: A Genome-Wide Study and Functional Characterization in Response to Stress
Authors: Brasileiro Ana Cristina Miranda , Gimenes Marcos Aparecido , Pereira Bruna Medeiros , Mota Ana Paula Zotta , Aguiar Matheus Nascimento , Martins Andressa Cunha Quintana , Passos Mario Alfredo Saraiva , Guimaraes Patricia Messenberg 
Published: December 2023

Peanut (Arachis hypogaea) and its wild relatives are among the few species that naturally synthesize resveratrol, a well-known stilbenoid phytoalexin that plays a crucial role in plant defense against biotic and abiotic stresses. Resveratrol has received considerable attention due to its health benefits, such as preventing and treating various human diseases and disorders. Chalcone (CHS) and Stilbene (STS) Synthases are plant-specific type III Polyketide Synthases (PKSs) that share the same substrates and are key branch enzymes in the biosynthesis of flavonoids and stilbenoids, respectively. Although resveratrol accumulation in response to external stimulus has been described in peanut, there are no comprehensive studies of the CHS and STS gene families in the genus Arachis. In the present study, we identified and characterized 6 CHS and 46 STS genes in the tetraploid peanut and an average of 4 CHS and 22 STS genes in three diploid wild species (Arachis duranensis, Arachis ipaënsis and Arachis stenosperma). The CHS and STS gene and protein structures, chromosomal distributions, phylogenetic relationships, conserved amino acid domains, and cis-acting elements in the promoter regions were described for all Arachis species studied. Based on gene expression patterns of wild A. stenosperma STS genes in response to different biotic and abiotic stresses, we selected the candidate AsSTS4 gene, which is strongly induced by ultraviolet (UV) light exposure, for further functional investigation. The AsSTS4 overexpression in peanut hairy roots significantly reduced (47%) root-knot nematode infection, confirming that stilbene synthesis activation in transgenic plants can increase resistance to pathogens. These findings contribute to understanding the role of resveratrol in stress responses in Arachis species and provide the basis for genetic engineering for improved production of valuable secondary metabolites in plants.
LEVERAGE, PROFITABILITY DAN KINERJA KEUANGAN: BUKTI DARI PERUSAHAAN
Authors: Stevany Febreany  
Published: December 2023

Global economic conditions are experiencing a slowdown and the Covid-19 pandemic will have an impact on the construction sector in terms of project continuity and raw materials including a shift or relocation of the budget to focus on handling Covid-19. The purpose of this study to determine the effect of leverage and profitability partially and simultaneously on the company's financial performance. The research method is using secondary data, quantitative analysis. The finding are leverage and profitability have a partial effect on the company's financial performance, the results in the study of leverage have a negative effect and profitability have not significant effect. Leverage and profitability have a simultaneous effect on the company's financial performance.
A Historical and Current Review of Extended Reality Technologies and Applications
Authors: Joskowicz Jose 
Published: December 2023

<p>This paper provides a review of Extended Reality (ER) technologies and applications. The different technologies related to ER, such as Virtual Reality, Augmented Reality and Mixed Reality are introduced and explained, following an historical perspective. The basic technical concepts behind these technologies are briefly explained. Current applications are presented, including references to actual tools and systems, in order to clarify the concepts and the potential of the technologies. </p>
The Role of the Programming Trajectory in the Power Dissipation Dynamics and Energy Consumption of Memristive Devices
Authors: Miranda Enrique 
Published: December 2023

<p> Tuning the conductance of a memristive device is a process that requires energy and involves power dissipation. In this letter, the role the memory state programming strategy plays in this connection is investigated. To this end, the device model equations representing the electron transport and metal ion/oxygen vacancy displacement caused by the application of an external signal must be solved consistently. However, if instead of considering the applied voltage as the model input, a memory state trajectory is assumed, the model equations can be decoupled allowing an analytic description of the problem. In order to accomplish this objective a more accurate version of the dynamic memdiode model is used which incorporates additional physical considerations in the characteristic switching times. It is demonstrated that alternative trajectories (concave, convex, and sigmoidal) lead to a variety of energy consumption-maximum dissipated power relationships indicating the key role played by the selected programming strategy. This kind of study contributes to the basic understanding of the writing process of memristors (synaptic weight assignment) and sheds light on its electrical consequences. </p>
Effect of Oral Riboflavin and Direct-sun UV-A on Tumor Necrosis Factor Alpha (TNF-α) Concentrations in Tears of Mild-Moderate Keratoconus Patients
Authors: Aulia Reza , Suhardjo Pawiroranu  , Agni Angela Nurini , Indra Tri Mahayana  
Published: December 2023

Purpose: To determine the role of intra-silicon oil methotrexate injection to prevent Proliferative Vitreoretinopathy.
Study Design: Quasi experimental Study.
Place and Duration: Ophthalmology department of Sahiwal Teaching Hospital, Sahiwal from February 2022 to August 2022.
Methods: Study included patients of either gender, older than 19 years with rhegmatogenous retinal detachment with Proliferative vitreoretinopathy (PVR) grade B or less. There were two groups and each group had fifty-one patients. All patients underwent pars plana vitrectomy and silicon oil tamponade. Group 1 was control group. Group 2 had intravitreal injections of methotrexate 500mg at the end of surgery. We repeated the injections at 1st, 2nd, and 4th week postoperatively.
Results: There were 56 (54.9%) male and 46 (45.1%) female patients. Postoperatively visual acuity improved in thirty cases (58.82%) in group 1 and in forty-two cases (82.35%) in group 2. Postoperatively PVR developed in 11 (21.57%) patients in group 1 while in group 2 no patient had PVR. Recurrent Retinal detachment occurred in 9 (19.61%) patients in group 1 and 3 (5.88%) patients in group 2. Chi square test demonstrated statistically significant difference in the frequency of development of PVR and re-detachment of retina between two groups, p<0.05.
Conclusion: Methotrexate is an effective adjuvant used in Pars plana Vitrectomy for rhegmatogenous retinal detachment repair. It prevents Proliferative vitreoretinopathy resulting in better surgical and functional outcome.
A Pilot Study: Assessment of Therapeutic Effects 670 nm Photobiomodulation on Amblyopia
Authors: Ahadi Masoumeh , Abbasi Ali , Shahrokh Ramin  
Published: December 2023

Purpose: To evaluate positive effects of photobiomodulation in amblyopia treatment in patients with 8-13 year of age.
Study Design: interventional case series.
Place and Duration of Study: Shahid Beheshti University of Medical Sciences, Iran.
Methods: This study was conducted on 16 subjects with strabismic amblyopia. Subjects were assigned to two groups: Photobiomodulation (PBM) and control group. In the PBM group, patients used a portable device (Warp 10, Quantum device) in home 3 times a week. The amblyopic eye were irradiated by a device which emitted670 nm red light with 25 Joules/cm2 energy for 4 minutes. After irradiation, patients performed near work for 10 minutes. In the control group, patients were treated by using part time occlusion of non-amblyopic eye and near work for 3 months. Ophthalmic assessments including best corrected visual acuity (BCVA), refractive evaluation, slit lamp biomicroscopy, and funduscopy were performed before and four weeks, and three months after treatment.
Results: In the PBM group, the mean baseline BCVA was 0.24 ± 0.15 that improved to 0.49 ±0.24 in the third month after treatment. In the control group, the mean initial BCVA was 0.30 ± 0.20 that increased to 0.44 ± 0.23 after three months. Our results showed improvement of 2.50 ± 1.16 lines in the PBM group (P<.001) and 1.38 ± 0.72 lines in the control group (P=0.040). Our assessments showed no adverse related to the PBM in patients.
Conclusion: PBM facilitates and accelerates the occlusion therapy in amblyopia and it can be considered a treatment option for amblyopia.
Accuracy of Icare Rebound Tonometer and Its Comparison with Goldman Applanation Tonometer
Authors: Farid Anila , Memoona Arshad  , Nimra Gul  , Shabana chaudhary  , Muhammad Zubair Nazar  
Published: December 2023

Purpose: To determine accuracy of iCare rebound tonometer (IRT) in terms of agreement with Goldman Applanation Tonometer (GAT) and effect of Central corneal thickness (CCT) on its accuracy.
Study Design: Comparative cross sectional study.
Place and Duration of Study: Ophthalmology Department of Ittefaq Hospital Lahore from September 2022 to May 2023.
Methods: Participants of the study were recruited through non-probability convenient sampling. With Icare PRO® rebound tonometer (IRT), two consecutive sets of measurements with 6 measurements for each set were made, and the averaged values were used for the statistical analyses. After 5 minutes GAT measurement was taken for intraocular pressure (IOP). CCT was measured by ultrasound pachymetry from mean of 2 measurements noted. Data was analyzed by Bland-Altman plots for determining agreement of GAT-IOP and IRT-IOP. Pearson correlation coefficient determined the correlation of GAT-IOP and IRT-IOP with CCT.
Results: Out of 200 participants there were 76 (38%) males and 124 (62%) females. Mean age of participants was 27.84 ± 6.1 years. Mean IOP with IRT was 16.24 ± 2.02 (range 12.1 – 20.3 mmHg). Mean IOP with GAT was 14.40 ± 1.98 (range 11.00 – 19 mmHg). Mean IOP with adjusted CCT using GAT was 14.40 ± 1.64 (range 11 – 18 mmHg). Mean CCT was 544.81 ± 42.04 (range 615 – 471 um). Mean IOP-GAT & IOP-IRT with adjusted CCT showed normal distribution. Mean difference of IOP-GAT and IOP-IRT with t test was 1.83 ± 1.12 (p = .079).
Conclusion: There is a strong agreement between IOP-GAT and IOP-IRT. CCT had a strong impact on IOP measurements with both tonometers. However, CCT affected IOP reading of GAT more than IRT.
Safety of Suprachoroidal Triamcinolone Acetonide Injection without Cannula Sleeve: A Modified Technique
Authors: Muhammad Hasnain  , Syed Fawad Rizvi  
Published: December 2023

Purpose: To evaluate safety of a new technique of Suprachoroidal (SC) injection of Triamcinolone Acetonide (TA) without need of cannula sleeve.
Study Design: Quasi experimental study.
Place and Duration of Study: LRBT Korangi from July 2020 to June 2021.
Methods: Fifty eyes of forty two patients with Diabetic Macular Edema not resolved with three consecutive intravitreal injection of Bevacizumab were included. A custom made 30 gauge needle on 1cc insulin syringe without cannula sleeve was used for injection of 0.1 ml (4 mg) Triamcinolone Acetonide.
Results: Mean age was 50.8 13.77 years. Mean IOP readings pre injection, after injection at 5 minutes, 30 minutes, 1 hour, 2 hour, 1 week, 1 month and 3 months were 12.76 , 14.8 , 14.5 , 14.6 4.46, 14.7 4.52,14.7 , 12.98 and 12.83 2.62 mm of Hg respectively. Mean BCVA (Log MAR) before injection, 1 month and 3 months after injection were 0.9 ± 0.1, 0.6 ± 0.2 and 0.6 ± 0.2 respectively. Mean CMT values before injection, 1 month and 3 months after injection were 408.4 ± 112.94, 348.67 ± 108.94 and 330.36 ± 105.77 µm respectively. Significant difference was observed between pre-injection IOP and post injection IOP within 2 hours but no significant difference in later readings. BCVA and CMT showed statistically significant improvement.
Conclusion: SC injection of TA without cannula sleeve is quite simple and apart from transient increase in IOP immediately after injection no significant adverse effects occur.
Development of steroid-resistant nephrotic syndrome in a child with CAKUT-syndrome
Authors: Zaikova N. M. , Mikhalkova D. Yu. , Dlin V. V. , Smirnova A. V. 
Published: December 2023

BACKGROUND. One of the congenital anomalies of the kidneys and urinary tracts (CAKUT) is renal hypodysplasia/aplasia type 3 (PHDA3), caused by pathogenic variants in the GREB1L gene not associated with steroid-resistant nephrotic syndrome (SRNS). PGDA3 leads to chronic kidney disease (CKD). Variants in the UMOD gene associated with autosomal dominant tubulointerstitial kidney disease (ATKD-UMOD) also lead to CKD. The association of the GREB1L/UMOD genes with SRNS has not been previously described.THE AIM: to demonstrate a rare clinical case of SRNS in a child with CAKUT-syndrome.PATIENTS AND METHODS. A patient with CAKUT in the form of PGDA3 and ADTBP-UMOD is observed in the department of nephrology for 2 years. Post-infectious development of SRNS required a revision of the genetic screening.RESULTS. On the whole-genome sequencing were found a variability in the genes that cause CAKUT, with no candidate genes for SRNS.CONCLUSION. The described case stands out with clinical polymorphism of CAKUT and the variability of UMOD and GREB1L gene variants not associated with the development of SRNS. Infectious etiology of the development of SRNS is assumed. The patient has an intensive development of CKD stage 4, requiring a long-term follow-up in dynamics.