bluuebunny/crossref_metadata_2025_split huggingface dataset:
System's Crisis Resilience as a Societal Crisis: Knowledge Structure and Gaze of the Finnish Health Care System
Authors: Heikkilä Matias , Heino Ossi , Rautiainen Pauli 
Published: January 2024

AbstractThe crisis resilience of vital social systems is currently the target of constant development efforts in Finland, as their drifting into crisis would weaken societies’ functional abilities, safety, and security. This is also the case regarding the Finnish health care system. In an attempt to move beyond existing frameworks of crisis imagination, this article takes an unconventional stance by elucidating endogenous crisis dynamics present in the Finnish health care system. Delphi process was conducted for top experts in Finnish health care and crisis management. With a dissensus-seeking orientation, our aim was to fertilize disagreements among panelists to reveal key vulnerabilities in the health system. Despite our efforts to evoke dissensus, the panelists ended up generating a consensus that aims to protect the underlying assumptions of the health system’s knowledge structure. Through inductive analysis of expert discourses, the data was analyzed through our research question “what constitutes a crisis-proof health system and a crisis-prone health system”. What is framed as a strength of the system by our panelists, namely the ability to maintain legitimacy, improve efficiency, and guarantee continuity, can still have questionable implications that are left ungrasped. A system’s theory approach illustrates how such effects can develop and escalate beyond the reach of social interventions, and thus be predisposed to cause objectionable yet concealed social crises. The discussion illustrates how these endogenous crisis dynamics could be seen to materialize in real-life cases.
Women’s and Provider’s Moral Reasoning About the Permissibility of Coercion in Birth: A Descriptive Ethics Study
Authors: Eichinger Johanna , Büchler Andrea , Arnold Louisa , Rost Michael 
Published: January 2024

AbstractEvidence shows that during birth women frequently experience unconsented care, coercion, and a loss of autonomy. For many countries, this contradicts both the law and medical ethics guidelines, which emphasize that competent and fully informed women’s autonomy must always be respected. To better understand this discordance, we empirically describe perinatal maternity care providers’ and women’s moral deliberation surrounding coercive measures during birth. Data were obtained from 1-on-1 interviews with providers (N = 15) and women (N = 14), and a survey of women (N = 118). Analyses focused on an in-depth exploration of responses to a question on the permissibility of coercion in birth whose wording was borrowed from a Swiss medical-ethical guideline. Reasons for and against a principle permissibility of coercive measures in birth were grouped into clusters of reasons to build a coherent explanatory framework. Factors considered morally relevant when deliberating on coercion included women’s decisional capacity, beneficence/non-maleficence, authority through knowledge on the part of providers, flaws of the medical system, or the imperative to protect the most vulnerable. Also, we identified various misconceptions, such as the conviction that a pathological birth can justify coercion or that fetal rights can justifiably infringe on women’s autonomy. Information and education on the issue of coercion in birth are urgently needed to enable women to fully exercise their reproductive autonomy, to prevent long-term adverse health outcomes of women and children, and to reconcile the medical vigilance which has lead to a reduction of perinatal morbidity and mortality with women’s enfranchisement in their own care.
Non-cognitive traits and homeownership in Australia
Authors: Mintah Kwabena , Baako Kingsley Tetteh , Churchill Sefa Awaworyi 
Published: January 2024

AbstractWe empirically examine the nexus between Locus of Control (LoC) and housing tenure in Australia. Drawing on data from the Household, Income and Labour Dynamics Survey for the period 2001–2021, we find that being internal on LoC is associated with a higher likelihood of homeownership and transitioning from renting to owning a home, while being external on LoC is more likely to lead to the opposite. This result is consistent across multiple robustness checks. We also find evidence that social capital and income are transmission mechanisms through which LoC influences housing tenure. We provide some suggestions for policy.
Norwegian Outdoor Happiness: Residential Outdoor Spaces and Active Leisure Time Contributions to Subjective Well-being at the National Population Level at the Start of and During the COVID-19 Pandemic
Authors: Grau-Ruiz Raul , Løvoll Helga Synnevåg , Dyrdal Gunvor Marie 
Published: January 2024

AbstractAccumulating research shows that residential nature reliably promotes residents’ subjective well-being (SWB) in complex ways. The present study investigates how self-reported proximity to different outdoor spaces relate to SWB in Norway. The effects of having proximity to recreation and hiking areas and the frequency of moderate-to-vigorous intensity leisure-time physical activity (MVLTPA) were estimated for five SWB measures (satisfaction with life, positive, and negative affect, mental well-being, and meaning in life). The study also estimated how outdoor spaces promote MVLTPA, and which of these relationships changed during the COVID-19 pandemic. Two Norwegian samples (collected in 2020 and 2021; N = 34,904) were explored using multiple linear and multinomial logistic regression analyses. Residential outdoor spaces predicted higher SWB across measures and MVLTPA frequency. Importantly, an inverted U-shaped relationship between MVLTPA and all SWB measures was found, with a tipping point coinciding with weekly MVLTPA. Last, during the pandemic, outdoor spaces became stronger predictors: hiking areas for mental well-being and meaning in life; and recreation areas for MVLTPA (p < .05). This study refines our understanding of these complex relations and contributes to setting these effects in perspective with other sociodemographic factors and SWB measures. Lastly, the importance of residential outdoor spaces upon the prospect of future pandemics is discussed.
The non-vesicle cell-free DNA (cfDNA) induces cell transformation associated with horizontal DNA transfer
Authors: De La Cruz-Sigüenza D. A. , Reyes-Grajeda J. P. , Velasco-Velázquez M. A. , Trejo-Becerril C. , Pérez-Cárdenas E. , Chávez-Blanco A. , Taja-Chayeb L. , Domínguez-Gómez G. , Ramos-Godinez M. P. , González-Fierro A. , Dueñas-González A. 
Published: January 2024

Abstract

Background
Cell-free DNA (cfDNA) is a source for liquid biopsy used for cancer diagnosis, therapy selection, and disease monitoring due to its non-invasive nature and ease of extraction. However, cfDNA also participates in cancer development and progression by horizontal transfer. In humans, cfDNA circulates complexed with extracellular vesicles (EV) and macromolecular complexes such as nucleosomes, lipids, and serum proteins. The present study aimed to demonstrate whether cfDNA not associated with EV induces cell transformation and tumorigenesis.

Methods
Supernatant of the SW480 human colon cancer cell line was processed by ultracentrifugation to obtain a soluble fraction (SF) and a fraction associated with EV (EVF). Primary murine embryonic fibroblast cells (NIH3T3) underwent passive transfection with these fractions, and cell proliferation, cell cycle, apoptosis, cell transformation, and tumorigenic assays were performed. Next, cfDNA was analyzed by electronic microscopy, and horizontal transfer was assessed by human mutant KRAS in recipient cells via PCR and recipient cell internalization via fluorescence microscopy.

Results
The results showed that the SF but not the EVF of cfDNA induced proliferative and antiapoptotic effects, cell transformation, and tumorigenesis in nude mice, which were reduced by digestion with DNAse I and proteinase K. These effects were associated with horizontal DNA transfer and cfDNA internalization into recipient cells.

Conclusions
The results suggest pro-tumorigenic effects of cfDNA in the SF that can be offset by enzyme treatment. Further exploration of the horizontal tumor progression phenomenon mediated by cfDNA is needed to determine whether its manipulation may play a role in cancer therapy.
Extension of the Geomorphic Flood Index classifier to predict flood inundation maps for uncalibrated rainfall depths in arid regions
Authors: Hamouda Mohamed A. , Awadallah Ayman G. , Abdel-Maguid Ramadan H. 
Published: January 2024

AbstractFlash floods are a rapid hydrological response that occurs within a short time with rapidly rising water levels and could lead to massive structural, social and economic damages. Therefore, generating flood inundation maps becomes necessary to distinguish areas exposed to floods. Hydrodynamic models are commonly used to generate inundation maps; however, they require high computational power and time, depending on the complexity of the model. For that, researchers developed effective, fast and simplified models. Among the simplified models, the Geomorphic Flood Index (GFI) is one of the most useful classifiers to generate inundation maps. Three main objectives are addressed in this study: (1) extend the GFI classifier to predict flood extent maps for uncalibrated rainfall depths, which will enhance early warning models for better risk assessments of extreme events; (2) enhance the accuracy of the simulated inundation maps using different calibration methods; and (3) investigate the performance of the GFI in various terrains with different resolutions. Three case studies in arid regions in Saudi Arabia were examined with different topographies, using terrains of high resolutions of 1 m and resampled low resolutions, as well as various rainfall depths corresponding to 5–100-yr return periods. The HEC-RAS 2D model was used to generate reference flood inundation maps. The obtained flood extent maps show high similarity compared to the reference maps with accuracy above 80%. Strong relationships between rainfall depths and the threshold GFI parameter were developed which allow producing inundation maps for any rainfall event.
What do we know about the choices of entrepreneurs before the equity crowdfunding campaign?
Authors: Correia Sandra , Sousa Miguel , Brandão Elísio 
Published: January 2024

AbstractThis literature survey focuses on the pre-investment phase of equity crowdfunding, encompassing three key areas: (i) a comparative analysis of equity crowdfunding (ECF) in relation to traditional sources of entrepreneurial funding, such as venture capital and business angels; (ii) a discussion on why and when entrepreneurs prefer ECF; and (iii) an in-depth examination of the diverse models of ECF platforms. This paper is relevant for both practice and research. It can help entrepreneurs to identify under what circumstances ECF might be preferable to traditional sources of start-up funding and which platform model best suits their needs. It is also relevant for research because, besides providing an organized summary of the literature on this new way of financing start-ups, it also identifies some inconsistencies and gaps in the existing literature, providing some clues for further investigations.
A Statistical Study of Solar White-Light Flares Observed by the White-Light Solar Telescope of the Lyman-Alpha Solar Telescope on the Advanced Space-Based Solar Observatory (ASO-S/LST/WST) at 360 nm
Authors: Jing Zhichen , Li Ying , Feng Li , Li Hui , Huang Yu , Li Youping , Su Yang , Chen Wei , Tian Jun , Song Dechao , Li Jingwei , Xue Jianchao , Zhao Jie , Lu Lei , Ying Beili , Zhang Ping , Su Yingna , Zhang Qingmin , Li Dong , Ge Yunyi , Li Shuting , Li Qiao , Li Gen , Liu Xiaofeng , Shi Guanglu , Shan Jiahui , Tian Zhengyuan , Zhou Yue , Gan Weiqun 
Published: January 2024

AbstractSolar white-light flares (WLFs) are those accompanied by brightenings in the optical continuum or integrated light. The White-light Solar Telescope (WST), as an instrument of the Lyman-alpha Solar Telescope (LST) on the Advanced Space-based Solar Observatory (ASO-S), provides continuous solar full-disk images at 360 nm, which can be used to study WLFs. We analyze 205 major flares above M1.0 from October 2022 to May 2023 and identify 49 WLFs at 360 nm from WST observations, i.e. with an occurrence rate of 23.9%. The percentages of WLFs for M1 – M4 (31 out of 180), M5 – M9 (11 out of 18), and above X1 (7 for all) flares are 17.2%, 61.1%, and 100%, respectively, namely the larger the flares, the more likely they are WLFs at 360 nm. We further analyze 39 WLFs among the identified WLFs and investigate their properties such as white-light enhancement, duration, and brightening area. It is found that the relative enhancement of the white-light emission at 360 nm is mostly (>90%) less than 30% and the mean enhancement is 19.4%. The WLFs’ duration at 360 nm is mostly (>80%) less than 20 minutes and its mean is 10.3 minutes. The brightening area at 360 nm is mostly (>75%) less than 500 arcsecond2 and the median value is 225. We find that there exist good correlations between the white-light enhancement/duration/area and the peak soft X-ray (SXR) flux of the flare, with correlation coefficients of 0.68, 0.58, and 0.80, respectively. In addition, the white-light emission in most WLFs peaks around the same time as the temporal derivative of SXR flux as well as the hard X-ray emission at 20 – 50 keV, indicative of the Neupert effect. It is also found that the limb WLFs are more likely to have a greater enhancement, which is consistent with numerical simulations.
Effects of temperament during handling and social rank on the blood biochemical parameters of common eland (Taurotragus oryx)
Authors: Musa A. S. , Kundankumar J. , Needham T. , Kotrba R. , Ny V. , Consolacion J. , Ceacero F. 
Published: January 2024

AbstractLarge herbivores are subject to handling and social stress in captivity. These may affect blood biochemical values, which motivated this research. Twelve healthy common eland (Taurotragus oryx) were monitored for 12 months. The animals were handled monthly, and blood samples were collected. Samples from every second month were analysed for 14 blood biochemical parameters. Temperament throughout the handling, as the summation of various behavioural responses, was calculated as a proxy of the stress generated during handling. Social behaviour was recorded each month, and the agonistic interactions were used to calculate the social rank, which was considered a proxy of social stress. Generalised Linear Mixed Models were designed to test the effects of temperament and social rank on the blood biochemical parameters while keeping sex, age, body condition, and body weight as covariates. The results show that the temperament during handling influences blood levels of albumin, alkaline phosphate, blood urea nitrogen, glucose, total bilirubin, and total protein; however, social rank has little influence, affecting just albumin. The ranges observed in the values of these biochemical parameters were still within their reference intervals, implying the absence of pathology or physiological problems during the study. The results suggest that blood biochemical values of physically restrained common eland should be carefully interpreted, even in animals already habituated to routine handling. On the contrary, social rank has low effects on the blood biochemical parameters.
Working with digital textbooks or printed materials: A study with boys and girls on conditional probability
Authors: Brnic Maxim , Greefrath Gilbert , Reinhold Frank 
Published: January 2024

AbstractThe integration of dynamic visualisations, feedback formats and digital tools is characteristic of state-of-the-art digital mathematics textbooks. Although there already is evidence that students can benefit from these technology-based features in their learning, the direct comparison between the use of a comparable digital and printed resource has not yet been sufficiently investigated. We address this research gap by contrasting the use of an enriched digital textbook that includes these features and comparable printed materials without them. To do so, we investigate the achievement of 314 students in a pretest-posttest control group design in a five-hour series of lessons on conditional probability. Using the Rasch model and mixed ANOVA, the results indicate that students can benefit from digital textbook features, especially compared to the use of comparable printed materials. In line with other studies on mathematical achievement and the use of digital resources, our study also shows differences between boys and girls. It seems that particularly girls benefit from the use of the digital textbook, whereas, for the boys, it does not seem to make a difference what kind of resources they use. The group and gender differences are discussed against the background of other studies considering that, especially in Bayesian situations, the way statistical situations are visualised can be decisive for a student’s performance.
The tellurite resistance gene cluster of pathogenic bacteria and its effect on oxidative stress response
Authors: Vávrová Silvia , Grones Jozef , Šoltys Katarína , Celec Peter , Turňa Ján 
Published: January 2024

AbstractTellurite resistance gene clusters have been identified in numerous pathogenic bacteria, including clinical isolates of Escherichia coli. The rareness of tellurium in host organisms and the noncontaminated environment raises a question about the true functionality of tellurite resistance gene clusters in pathogenesis and their possible contribution to bacterial fitness. The study aims to point out the beneficial effects of the tellurite resistance gene cluster of pathogenic bacteria to survive in ROS-rich environments. Here, we analysed the bacterial response to oxidative stress conditions with and without tellurite resistance gene clusters, which are composed of terWY1XY2Y3 and terZABCDEF genes. By measuring the levels of protein carbonylation, lipid peroxidation, and expression changes of oxidative stress genes upon oxidative stress, we propose a tellurite resistance gene cluster contribution to the elimination of oxidative damage, potentially increasing fitness and resistance to reactive oxygen species during macrophage attack. We have shown a different beneficial effect of various truncated versions of the tellurite resistance gene cluster on cell survival. The terBCDEF genes increased the survival of E. coli strain MC4100 by 13.21%, terW and terZABCDEF by 10.09%, and terWY1XY2Y3 and terZABCDEF by 25.57%, respectively. The ability to survive tellurite treatment is the most significant at 44.8% in wild clinical strain KL53 compared to laboratory strain E. coli MC4100 due to a complete wild-type plasmid presence.
Mitochondrial-mediated apoptosis as a therapeutic target for FNC (2′-deoxy-2′-b-fluoro-4′-azidocytidine)-induced inhibition of Dalton’s lymphoma growth and proliferation
Authors: Kumar Naveen , Kumar Sanjeev , Shukla Alok , Kumar Sanjay , Singh Rishi Kant , Ulasov Ilya , Kumar Sandeep , Patel Anand Kumar , Yadav Lokesh , Tiwari Ruchi , Rachana  , Mohanta Shivashish Priyadarshi , Kaushalendra  , Delu Vikram , Acharya Arbind 
Published: January 2024

Abstract
Purpose
T-cell lymphomas, refer to a diverse set of lymphomas that originate from T-cells, a type of white blood cell, with limited treatment options. This investigation aimed to assess the efficacy and mechanism of a novel fluorinated nucleoside analogue (FNA), 2′-deoxy-2′-β-fluoro-4′-azidocytidine (FNC), against T-cell lymphoma using Dalton’s lymphoma (DL)-bearing mice as a model.

Methods
Balb/c mice transplanted with the DL tumor model received FNC treatment to study therapeutic efficacy against T-cell lymphoma. Behavioral monitoring, physiological measurements, and various analyses were conducted to evaluate treatment effects for mechanistic investigations.

Results
The results of study indicated that FNC prevented DL-altered behavior parameters, weight gain and alteration in organ structure, hematological parameters, and liver enzyme levels. Moreover, FNC treatment restored organ structures, attenuated angiogenesis, reduced DL cell viability and proliferation through apoptosis. The mechanism investigation revealed FNC diminished MMP levels, induced apoptosis through ROS induction, and activated mitochondrial-mediated pathways leading to increase in mean survival time of DL mice. These findings suggest that FNC has potential therapeutic effects in mitigating DL-induced adverse effects.

Conclusion
FNC represents an efficient and targeted treatment strategy against T-cell lymphoma. FNC’s proficient ability to induce apoptosis through ROS generation and MMP reduction makes it a promising candidate for developing newer and more effective anticancer therapies. Continued research could unveil FNC’s potential role in designing a better therapeutic approach against NHL.
Artificial neural network approach to model Cr(III) and Cr(VI) adsorption by NCS, ACS and BCS
Authors: Göde Fethiye , Yılmaz Asuman , Aktaş A. Hakan , Pehlivan Erol 
Published: January 2024

AbstractAdsorption properties of Cr(III) and Cr(VI) on natural (NCS), acid-activated (ACS) and base-activated (BCS) cherry stalks (CS) in Isparta were investigated in aqueous solutions. Batch adsorption studies had been completed with different initial chromium concentrations, pH, temperature, time and biosorbent dosage. Adsorption rapidly approached an equilibrium state between 10 and 60 min. The results displayed that the adsorption system was suitable for pseudo-second-order kinetics. Equilibrium isotherms (Langmuir, Freundlich and Dubinin–Radushkevich) were measured experimentally. The retention characteristics of Cr(III) onto NCS, ACS and BCS and Cr(VI) onto ACS were represented by Langmuir adsorption isotherms, while Cr(VI) ions onto NCS and BCS were compatible with Freundlich adsorption isotherms. The adsorption process was endothermic accompanied by a decrease in entropy and Gibbs energy. An artificial neural network (ANN) model was improved to estimate the efficiency of Cr(III) and Cr(VI) ion’s adsorption. The ANN model can predict the behaviour of the Cr(III) and Cr(VI) ion's adsorption under different circumstances. The results have shown that NCS, ACS and BCS biosorbents open up new possibilities and potential commercial uses in the cherry stalks.
The Role of Rehabilitation for the Dying Cancer Patient
Authors: Arora Arpit , Chang Philip , Asher Arash 
Published: January 2024

Abstract
Purpose of Review
This article aims to expand on the role of rehabilitation clinicians in providing whole-person care to the dying cancer patient. We identify symptoms common at the end of life in patients with cancer and demonstrate how rehabilitation specialists can use medications and interventions to ease the dying process.

Recent Findings
Achieving adequate pain and symptom control can be done through a collaborative, multidisciplinary model with physiatrists, nurses, and therapists in all disciplines. Addressing anxiety, depression, and existential distress can and must be part of the whole-person rehabilitation care.

Summary
Achieving a “good death” is a collaborative process and one that is unique to each individual. Research has revealed that people want to be as symptom-free as possible, remain as functional and clear-thinking as possible, and contribute to those around them. The rehabilitation team is well-poised to help individuals meet these goals.