bluuebunny/crossref_metadata_2025_split huggingface dataset:
What makes a city ‘breastfeeding‐friendly’? A scoping review of indicators of a breastfeeding‐friendly city
Authors: Tan May Loong , Mohd Shukri Izz Amirah , Ho Jacqueline J. , O'Sullivan Elizabeth J. , Omer‐Salim Amal , McAuliffe Fionnuala M. 
Published: December 2023

AbstractA breastfeeding‐friendly city is one where there is an enabling environment to support breastfeeding throughout the first 2 years or more of a child's life. Indicators of a breastfeeding‐friendly city have yet to be identified. What are the indicators or criteria used to define breastfeeding friendliness in a geographic area such as a city and the settings within, which we have classified as community, healthcare and workplace? Three major databases and grey literature were searched. Records were screened to identify publications describing criteria such as indicators or descriptions of a breastfeeding‐friendly setting, defined as ‘criteria‐sets’. These criteria‐sets were then categorized and summarized by settings. The search up to 2 September 2021 found 119 criteria‐sets from a range of settings: geographic locations (n = 33), community entities (n = 24), healthcare facilities (n = 28), workplaces (n = 28) and others (n = 6). Overall, 15 community, 22 healthcare and 9 workplace related criteria were extracted from the criteria‐sets. Criteria that were consistently present in all settings were policy, training & education, skilled breastfeeding support and physical infrastructure. Some criteria‐sets of geographic locations contained criteria only from a single setting (e.g., the presence of breastfeeding‐friendly cafes). Criteria‐sets were present for all settings as defined in this review, but few were actual indicators. Specifically, there were no existing indicators of a breastfeeding‐friendly city. Several common components of the criteria‐sets were identified, and these could be used in developing indicators of a breastfeeding‐friendly city. Future studies should determine which of these are important and how each can be measured.
Identification of novel candidate biomarkers related to immune cell infiltration in peri‐implantitis
Authors: Chen Zhen , Yan Qi , Zhang Rui , Li Yuhong , Huang Shengfu 
Published: December 2023

AbstractObjectiveThe present study was performed to identify key biomarkers associated with immune cell infiltration in peri‐implantitis through bioinformatic analyses.MethodsSix peri‐implantitis soft tissue samples and six healthy gingiva samples were obtained from GSE106090, and were used to identify immune‐associated differentially expressed genes (DEGs) in peri‐implantitis. The candidate biomarkers associated with immune cell infiltration were examined by immunohistochemical staining.ResultsWe identified 2089 upregulated and 2173 downregulated genes. Upregulated DEGs were significantly associated with immune response. Ten key candidate biomarkers were identified in the PPI network, including IL1B, TLR2, TLR4, CCL4, CXCL8, IL10, IL6, CD4, CCL3, and PTPRC. The expression level of the 10 genes increased in peri‐implantitis soft tissue samples compared with healthy gingiva samples. The proportion of CD4+ T cells, iTreg, and Tfh in infiltration immune cells increased in peri‐implantitis soft tissue samples and were positively correlated with the expression level of candidate biomarkers TLR4, CCL3, CXCL8, and IL1B. Immunohistochemistry showed that there were more lymphocytes in peri‐implantitis soft tissue samples, with an increased expression level of TLR4, CCL3, CXCL8, and IL1B.ConclusionIdentification of four novel diagnostic biomarkers was helpful for revealing the molecular mechanisms and could serve as a risk predictor for the immune microenvironment in peri‐implantitis.
Which job attributes attract individuals high in public service motivation and self‐efficacy to a public service job?
Authors: Favero Nathan , Pedersen Mogens Jin , Park Joohyung 
Published: December 2023

AbstractWhich job attributes attract prospective high‐performing individuals to a job in the public sector? Research shows that the particular attributes of a job influence perceptions of job attractiveness. Moreover, public service motivation (PSM) and self‐efficacy are valuable individual‐level traits for public service performance. This article examines how variation within particular job attributes that are generic to many public service jobs may attract (or discourage) potential workers high in PSM and self‐efficacy—i.e., prospective high‐performers. We focus on eight job attributes encompassing total compensation, performance‐based incentives, job performance assessment, diverse service recipient characteristics, overtime commitments, and key job tasks. Using data from a pre‐registered conjoint survey experiment among 1501 US residents, we show how individuals higher in PSM and self‐efficacy (relative to their counterparts with lower levels of these traits) exhibit distinct reactions to the job attributes of performance‐based pay, service recipients’ resources and racial demographics, and key job tasks.
ZmELP1, an Elongator complex subunit, is required for the maintenance of histone acetylation and RNA Pol II phosphorylation in maize kernels
Authors: Li Jianrui , Gu Wei , Yang Zhijia , Chen Jian , Yi Fei , Li Tong , Li Jingrui , Zhou Yue , Guo Yan , Song Weibin , Lai Jinsheng , Zhao Haiming 
Published: December 2023

SummaryThe Elongator complex was originally identified as an interactor of hyperphosphorylated RNA polymerase II (RNAPII) in yeast and has histone acetyltransferase (HAT) activity. However, the genome‐wide regulatory roles of Elongator on transcriptional elongation and histone acetylation remain unclear. We characterized a maize miniature seed mutant, mn7 and map‐based cloning revealed that Mn7 encodes one of the subunits of the Elongator complex, ZmELP1. ZmELP1 deficiency causes marked reductions in the kernel size and weight. Molecular analyses showed that ZmELP1 interacts with ZmELP3, which is required for H3K14 acetylation (H3K14ac), and Elongator complex subunits interact with RNA polymerase II (RNAPII) C‐terminal domain (CTD). Genome‐wide analyses indicated that loss of ZmELP1 leads to a significant decrease in the deposition of H3K14ac and the CTD of phosphorylated RNAPII on Ser2 (Ser2P). These chromatin changes positively correlate with global transcriptomic changes. ZmELP1 mutation alters the expression of genes involved in transcriptional regulation and kernel development. We also showed that the decrease of Ser2P depends on the deposition of Elongator complex‐mediated H3K14ac. Taken together, our results reveal an important role of ZmELP1 in the H3K14ac‐dependent transcriptional elongation, which is critical for kernel development.
OsGELP77, a QTL for broad‐spectrum disease resistance and yield in rice, encodes a GDSL‐type lipase
Authors: Zhang Miaojing , Chen Dan , Tian Jingjing , Cao Jianbo , Xie Kabin , He Yuqing , Yuan Meng 
Published: December 2023

SummaryLipids and lipid metabolites have essential roles in plant–pathogen interactions. GDSL‐type lipases are involved in lipid metabolism modulating lipid homeostasis. Some plant GDSLs modulate lipid metabolism altering hormone signal transduction to regulate host‐defence immunity. Here, we functionally characterized a rice lipase, OsGELP77, promoting both immunity and yield. OsGELP77 expression was induced by pathogen infection and jasmonic acid (JA) treatment. Overexpression of OsGELP77 enhanced rice resistance to both bacterial and fungal pathogens, while loss‐of‐function of osgelp77 showed susceptibility. OsGELP77 localizes to endoplasmic reticulum and is a functional lipase hydrolysing universal lipid substrates. Lipidomics analyses demonstrate that OsGELP77 is crucial for lipid metabolism and lipid‐derived JA homeostasis. Genetic analyses confirm that OsGELP77‐modulated resistance depends on JA signal transduction. Moreover, population genetic analyses indicate that OsGELP77 expression level is positively correlated with rice resistance against pathogens. Three haplotypes were classified based on nucleotide polymorphisms in the OsGELP77 promoter where OsGELP77Hap3 is an elite haplotype. Three OsGELP77 haplotypes are differentially distributed in wild and cultivated rice, while OsGELP77Hap3 has been broadly pyramided for hybrid rice development. Furthermore, quantitative trait locus (QTL) mapping and resistance evaluation of the constructed near‐isogenic line validated OsGELP77, a QTL for broad‐spectrum disease resistance. In addition, OsGELP77‐modulated lipid metabolism promotes JA accumulation facilitating grain yield. Notably, the hub defence regulator OsWRKY45 acts upstream of OsGELP77 by initiating the JA‐dependent signalling to trigger immunity. Together, OsGELP77, a QTL contributing to immunity and yield, is a candidate for breeding broad‐spectrum resistant and high‐yielding rice.
Alternative method for determining leaf CO2 assimilation without gas exchange measurements: Performance, comparison and sensitivity analysis
Authors: Kimura Kensuke , Kumagai Etsushi , Fushimi Erina , Maruyama Atsushi 
Published: December 2023

AbstractWe present an alternative method to determine leaf CO2 assimilation rate (An), eliminating the need for gas exchange measurements in proximal and remote sensing. This method combines the Farquhar–von Caemmerer–Berry photosynthesis model with mechanistic light reaction (MLR) theory and leaf energy balance (EB) analysis. The MLR theory estimates the actual electron transport rate (J) by leveraging chlorophyll fluorescence via pulse amplitude‐modulated fluorometry for proximal sensing or sun‐induced chlorophyll fluorescence measurements for remote sensing, along with spectral reflectance. The EB equation is used to directly estimate stomatal conductance from leaf temperature. In wheat and soybean, the MLR‐EB model successfully estimated An variations, including midday depression, under various environmental and phenological conditions. Sensitivity analysis revealed that the leaf boundary layer conductance (gb) played an equal, if not more, crucial role compared to the variables for J. This was primarily caused by the indirect influence of gb through the EB equation rather than its direct impact on convective CO2 exchange on the leaf. Although the MLR‐EB model requires an accurate estimation of gb, it can potentially reduce uncertainties and enhance applicability in photosynthesis assessment when gas exchange measurements are unavailable.
Etioplasts are more susceptible to salinity stress than chloroplasts and photosynthetically active etio‐chloroplasts of wheat (Triticum aestivum L.)
Authors: Ounoki Roumaissa , Sóti Adél , Ünnep Renáta , Sipka Gábor , Sárvári Éva , Garab Győző , Solymosi Katalin 
Published: December 2023

AbstractHigh soil salinity is a global problem in agriculture that directly affects seed germination and the development of the seedlings sown deep in the soil. To study how salinity affected plastid ultrastructure, leaf segments of 11‐day‐old light‐ and dark‐grown (etiolated) wheat (Triticum aestivum L. cv. Mv Béres) seedlings were floated on Hoagland solution, 600 mM KCl:NaCl (1:1) salt or isosmotic polyethylene glycol solution for 4 h in the dark. Light‐grown seedlings were also treated in the light. The same treatments were also performed on etio‐chloroplasts of etiolated seedlings greened for different time periods. Salt stress induced slight to strong changes in the relative chlorophyll content, photosynthetic activity, and organization of thylakoid complexes. Measurements of malondialdehyde contents and high‐temperature thermoluminescence indicated significantly increased oxidative stress and lipid peroxidation under salt treatment, except for light‐grown leaves treated in the dark. In chloroplasts of leaf segments treated in the light, slight shrinkage of grana (determined by transmission electron microscopy and small‐angle neutron scattering) was observed, while a swelling of the (pro)thylakoid lumen was observed in etioplasts. Salt‐induced swelling disappeared after the onset of photosynthesis after 4 h of greening. Osmotic stress caused no significant alterations in plastid structure and only mild changes in their activities, indicating that the swelling of the (pro)thylakoid lumen and the physiological effects of salinity are rather associated with the ionic component of salt stress. Our data indicate that etioplasts of dark‐germinated wheat seedlings are the most sensitive to salt stress, especially at the early stages of their greening.
Genomic and Transcriptomic Analyses Illuminates Unique Traits of Elusive Night Flowering Jasmine Parijat (Nyctanthes arbor‐tristis)
Authors: Patil Ajinkya Bharatraj , Kar Debojyoti , Datta Sourav , Vijay Nagarjun 
Published: December 2023

AbstractThe night‐flowering Jasmine, Nyctanthes arbor‐tristis also known as Parijat, is a perennial woody shrub belonging to the family of Oleaceae. It is popular for its fragrant flowers that bloom in the night and is a potent source of secondary metabolites. However, knowledge about its genome and the expression of genes regulating flowering or secondary metabolite accumulation is lacking. In this study, we generated whole genome sequencing data to assemble the first de novo assembly of Parijat and use it for comparative genomics and demographic history reconstruction. The temporal dynamics of effective population size (Ne) experienced a positive influence of colder climates suggesting the switch to night flowering may have provided an evolutionary advantage. We employed multi‐tissue transcriptome sequencing of floral stages/parts to obtain insights into the transcriptional regulation of nocturnal flower development and the production of volatiles/metabolites. Tissue‐specific transcripts for mature flowers revealed key players in circadian regulation and flower development, including the auxin pathway and cell wall modifying genes. Furthermore, we identified tissue‐specific transcripts responsible for producing numerous secondary metabolites, mainly terpenoids and carotenoids. The diversity and specificity of Terpene Synthase (TPS) and CCDs (Carotenoid Cleavage Deoxygenases) mediate the bio‐synthesis of specialised metabolites in Parijat. Our study establishes Parijat as a novel non‐model species to understand the molecular mechanisms of nocturnal blooming and secondary metabolite production.
The impact of CO2 emissions and climate on economic growth and productivity: International evidence
Authors: Rigas Nikos , Kounetas Konstantinos Elias 
Published: December 2023

AbstractIn this study, we apply a detailed country level data in the 1961–2015 period to investigate the relationship between weather variables, CO2, share of renewable energy sources, gross domestic product, and total factor productivity in a standard Cobb–Douglas production function by using an instrumental variable approach. Our findings suggest that economic growth has been positively affected by temperature and CO2 emissions, while climate vulnerability varies significantly between rich‐poor countries. Furthermore, the negative nexus between renewable sources and CO2 emissions demonstrates its importance for optimal environmental policies design while an inverted U‐shaped relationship for temperature and emissions.
Network effect and international currency
Authors: Liu Tao , Wang Xiaosong , Woo Wing Thye 
Published: December 2023

AbstractThe network effect is an important factor for the inertia and path dependence in the international monetary system. In this paper, we explore its influence, both theoretically and empirically: (a) by extending the standard monetary search model to a three‐country three‐currency model with multiple transitions to clarify the network effect on currency choices; (b) by showing empirically that the network effect is positive, statistically significant, and quantitatively comparable with other factors, such as trade share. The empirical results hold both for major international currencies and emerging currencies, such as RMB, and for various estimation specifications and subsamples.
Island effects and amelioration by resumption in Jordanian Arabic: An auditory acceptability‐judgment study
Authors: Al‐Aqarbeh Rania , Sprouse Jon 
Published: December 2023

AbstractThis study brings evidence from Jordanian Arabic, a primarily spoken grammatical‐resumption language, into the (formal‐experimental) empirical base of both theories of island effects and theories of island amelioration by resumption. We report four auditory judgment studies exploring two dependency types and four island types with a gap or resumption in the tail of the dependency, yielding 16 distinct quantified effects. Our experiments identified two notable sources of variation: variation across dependency types in the sets of island effects that occur with gaps and variation across island types in amelioration by resumption. We discuss the challenges these results raise for four major classes of theories of island effects, and we point to paths forward for each. We also discuss the consequences of the variation in amelioration for theories of the source of resumption, concluding that both base generation and movement must be available options to learners of Jordanian Arabic. We also observe some evidence of individual variation in the availability of resumption across dependency types that could be explored in future studies.
Reporting and analysis of process-of-care time measures in clinical trials for hyperacute stroke interventions: a scoping review protocol
Authors: Italiano Dominic , Johns Hannah , Campbell Bruce , Turc Guillaume , Churilov Leonid 
Published: December 2023

Objective:
The objective of this scoping review is to investigate the reporting and comparison of process-of-care time measures in hyperacute stroke trials and systematic reviews of trials (subsequently referred to as “studies”).

Introduction:
Stroke is a leading cause of death and disability worldwide. A crucial factor in determining the effectiveness of stroke care in improving patient outcomes is time; therefore, time measures are frequently reported in studies of hyperacute stroke interventions. However, there is inconsistency in how these measures are reported and compared. Furthermore, there is a lack of clarity in how compatible the reporting methods are with the statistical analysis methods.

Inclusion criteria:
This scoping review will include studies that report and/or compare time measures between key events of interest in the delivery of hyperacute stroke care. Studies of thrombolytic therapy and/or thrombectomy, as well as controlled trials of mobile stroke unit interventions, will be included.

Methods:
The scoping review will be conducted in accordance with the Preferred Reporting Items for Systematic Reviews and Meta-Analyses extension for Scoping Reviews (PRISMA-ScR) and the JBI methodology for scoping reviews. The search will be executed in MEDLINE (PubMed), Embase (Ovid), and clinical trial registries ANZCTR, ISRCTN, and ClinicalTrials.gov. Title and abstract screening will be followed by full-text screening and subsequent data extraction from eligible studies. The results from this scoping review will be presented in tables and narratively summarized.

Review registration:
Open Science Framework https://osf.io/y98wz
Network‐based systematic dissection of exercise‐induced inhibition of myosteatosis in older individuals
Authors: Iijima Hirotaka , Ambrosio Fabrisia , Matsui Yusuke 
Published: December 2023

AbstractAccumulated fat in skeletal muscle (i.e. myosteatosis), common in sedentary older individuals, compromises skeletal muscle health and function. A mechanistic understanding of how physical activity levels dictate fat accumulation represents a critical step towards establishment of therapies that promote healthy ageing. Using a network medicine paradigm that characterized the transcriptomic response of aged muscle to exercise versus immobilization protocols, this study explored the shared molecular cascade that regulates the fate of fibro‐adipogenic progenitors (FAPs), the cell population primarily responsible for fat accumulation. Specifically, gene set enrichment analyses with network propagation revealed Pgc‐1α as a functional hub of a large gene regulatory network underlying the regulation of FAPs by physical activity in aged muscle, but not in young counterparts. Integrated in silico and in situ approaches to induce Pgc‐1α overexpression in aged muscle promoted mitochondrial fatty acid oxidation and inhibited FAP adipogenesis. These findings suggest that the Pgc‐1α–mitochondrial fatty acid oxidation axis is a shared mechanism by which physical activity regulates age‐related myosteatosis. The network medicine paradigm introduced provides mechanistic insight into exercise adaptation in elderly skeletal muscle and offers translational opportunities to advance exercise prescription for older populations.
imageKey points
Fat accumulation is a quintessential feature of aged skeletal muscle.
While increasing physical activity levels has been proposed as an effective strategy to reduce the fat in skeletal muscle (i.e. myosteatosis), the molecular cascade underlying these benefits has been poorly defined.
This study implemented a series of network medicine approaches and uncovered Pgc‐1α as a mechanistic driver of the regulation of fibro‐adipogenic progenitors (FAPs) by physical activity.
Integrated in silico and in situ approaches to induce Pgc‐1α overexpression promoted mitochondrial fatty acid oxidation and inhibited FAP adipogenesis.
Together, the findings of the current study suggest a novel hypothesis that physical activity reduces myosteatosis via upregulation of Pgc‐1α‐mediated mitochondrial fatty acid oxidation and subsequent inhibition of FAP adipogenesis.
The Organization and Conduct of an Industrial Laboratory
Authors: Little A. D. , Howe H. E. 
Published: December 2023

Abstract
During the war industrial research in the United States was naturally stimulated, and as a result there now exists a deeper interest than heretofore in the applications of science to manufacturing processes. New laboratories will undoubtedly be built and many old ones reorganized in order to render more efficient service. It is the purpose of this paper to point out the organization and conduct of such a research laboratory.
The authors first outline the aims of a research organization, following which the divisions of the laboratory are enumerated and discussed, the laboratories of Arthur D. Little, Inc., being taken as a type. The methods of management, writing of reports and the commercial organization of the laboratory are also discussed at some length, and the paper concludes with a description of the building and equipment best suited to carry on this type of work.
Pulverized Coal as a Fuel
Authors: Harrison N. C. 
Published: December 2023

Abstract
The author first reviews some of the uses of pulverized coal in the industries — such as the cement, steel and copper industries, after which he gives a technical definition of pulverized coal, describes the process by which it is prepared for use and furnishes tables of costs of preparation. The pulverized-coal-burning open-hearth steel plant of the American Iron & Steel Manufacturing Co., Lebanon, Pa., is described and the advantages observed in the plant of pulverized coal, compared with producer gas as a fuel for open-hearth furnaces, are listed.
The use of pulverized coal in stationary boiler plants is discussed, five determining factors in the successful operation of such a plant being taken up in detail. As compared with mechanical-stoker plants the advantages of the pulverized-coal plant are enumerated and certain precautions to be observed with the latter type of plant are brought out.
A report of a test of a 468-hp. Edge Moor boiler with pulverized-coal equipment is included in the paper and the efficiency obtained is compared with the efficiency of a stoker-fed boiler in the same plant, a greater net efficiency being found in the pulverized-coal plant.
The paper concludes with a statement of some advantages obtained in the pulverized-coal plant.