bluuebunny/crossref_metadata_2025_split huggingface dataset:
A novel surgical technique for transscleral Gore-Tex suture-assisted rescue of dislocated CZ70BD intraocular lenses using 27-gauge instrumentation.
Authors: Thanos Aristomenis , Todorich Bozho 
Published: November 2023

Background and Objective:
To report a novel technique for refixation of dislocated CZ70BD intraocular lens (IOL).

Methods:
Vitrectomy trocars are placed along the horizontal meridian 5mm apart. A CV-8 Gore-Tex suture is introduced through a bare sclerotomy into the mid vitreous cavity. Under chandelier illumination, a 27G broad platform forceps is threaded through the eyelet of the dislocated CZ70BD IOL. Using another pair of intraocular forceps, the free intraocular end of the Gore-Tex is fed to the broad platform forceps and externalized, thus repositioning the IOL. Particular attention is drawn to pass the suture in an over and under configuration to avoid IOL tilt. An identical procedure is repeated for the other eyelet if the IOL is completely dislocated. The 23 or 25 gauge instruments should not be used for this technique as they do not fit loosely through the eyelets of the IOL.

Results:
Three eyes were successfully operated on using this technique with at least 6 months of follow up. There was significant improvement in best corrected visual acuity (BCVA) after the operation. Postoperative IOL centration and alignment were satisfactory.

Conclusion:
The described surgical technique is effective for transscleral Gore-Tex-assisted refixation of dislocated CZ70BD IOL.
Purposeful Gas Induced Resorption of Submacular Fluid in Macula-off Retinal Detachments (Persimmon Study)
Authors: Adrean Sean D. , Peng Enoch T. , Chaili Siyang , Grant Scott 
Published: November 2023

Abstract

Purpose:
To examine the visual outcomes in patients with macula-off rhegmatogenous retinal detachments (RD) with intentional submacular fluid (SRF) retention following pars plana vitrectomy (PPV) or pars plana vitrectomy/scleral buckle surgery (PPV/SB).

Methods:
Patients with macula-off RDs were included if they had a PPV or PPV/SB without drainage retinotomy or perfluorocarbon liquid (PFCL) to flatten the retina.

Results:
Mean patient age was 65.0 years. The mean presenting vision was 20.0 ETDRS letters. Six months after repair the vision improved to 62.9, 75.4% of patients had 20/40 or better at best achieved VA. Pseudophakic eyes had better vision compared to phakic (p=0.049). Patients younger than 80 had better best achieved vision (p=0.0118) compared to patients 80 or older. Patients with initial vision better than or equal to 20/100 had better best achieved vision (p=0.016) compared to those with initial vision worse than 20/100.

Conclusion:
Leaving SRF after macula-off RD surgery was not detrimental for visual outcomes or anatomic success for RD repair and may lead to better visual outcomes for patients, specifically for those patients younger than 80, that are pseudophakic and have presenting vision 20/100 or better.
Stress and Allostatic Load in Patients With Primary Open Angle Glaucoma
Authors: GC Kiran , Mahalingam Karthikeyan , Gupta Vivek , Angmo Dewang , Gupta Shikha , Dada Tanuj 
Published: November 2023

Précis:
This study evaluated the allostatic load (AL) in primary open angle glaucoma (POAG) patients and reported that the AL score was significantly higher in glaucoma patients compared with age-matched controls.

Purpose:
To evaluate the AL in patients with POAG.

Methods:
This case-control study comprised 50 POAG (glaucoma patients) and 50 age-matched controls without glaucoma (controls). AL was estimated based on 13 variables: systolic blood pressure (BP), diastolic BP, homocysteine, triglycerides, total cholesterol, high-density lipoprotein, low-density lipoprotein, body mass index, serum cortisol, glycosylated hemoglobin, albumin, creatinine clearance, and C-reactive protein. High-risk thresholds were determined based on biological cutoffs of each biomarker. One point was assigned for each biomarker reading above cutoff and were summated to obtain AL score; score ≥4 was considered high.

Results:
Mean age of glaucoma patients was 60.82±6.26 and 60.14±6.72 years in controls (P=0.602). All components of AL score (except C-reactive protein) had higher values in glaucoma patients. There was a statistically significant difference in homocysteine (P=0.001), total cholesterol (P=0.037), high-density lipoprotein (P=0.005), and glycosylated hemoglobin (P=0.003). Mean AL score was 4.68±2.09 in glaucoma patients and 3.32±1.34 in controls (P<0.001). There was significant association of high AL score with older age (P=0.006), low socioeconomic status (P=0.020), and glaucoma severity (P=0.001). Negative correlation was seen between AL and retinal nerve fiber layer thickness (Right Eye: r=−0.37, P<0.001; Left Eye: r=−0.298, P<0.001) and visual field mean deviation (Right Eye: r=−0.469, P<0.001; Left Eye: r=−0.520, P<0.001).

Conclusions:
Glaucoma patients exhibited allostatic overload indicating physiological dysregulation to chronic stress although additional research is required to establish causality. A holistic approach with lifestyle modifications to reduce chronic stress should be an integral part of managing glaucoma patients as it would serve both to possibly reduce or prevent disease progression and improve overall health outcomes.
Efficacy and Safety of an Adjustable Glaucoma Drainage Device (eyeWatch System) for Refractory Glaucoma: A 2-Year Prospective Study
Authors: Roy Sylvain , Mermoud André 
Published: November 2023

Précis:
In this study, we report a 2-year follow-up after implantation of an adjustable glaucoma drainage device combined with a novel orbital filtering plate. The IOP was efficiently controlled postoperatively with limited complications and an excellent safety profile.

Purpose:
To report the clinical results at 2 years after implantation of an eyeWatch (eW) system, which comprises an adjustable glaucoma drainage device (eW implant) combined with a novel orbital filtering plate (eyePlate), in refractory glaucoma.

Patients and Methods:
Monocentric, prospective, noncomparative clinical trial. Patients suffering from refractory glaucoma after several failed surgeries were operated using the eW system. The primary outcome was the success rate, defined as an IOP ≤18 mm Hg and reduction of more than 20% from baseline, IOP ≥6 mm Hg. Secondary outcomes were mean IOP, visual acuity, the number of antiglaucoma medications, and the number and type of complications.

Results:
Forty-two eyes from 42 patients were included. The mean follow-up time was 22.0±4.0 months. The mean baseline IOP decreased from 23.2±7.2 mm Hg before surgery to 11.9±4.4 mm Hg at 12 months (P<0.001) and 11.5±3.0 at 24 months. The mean number of glaucoma medications decreased from 2.9±0.9 before surgery to 0.7±0.9 at 12 months (P<0.001) and 1.0±0.9 at 24 months. The qualified success rate was 93% at 12 months and 90% at 24 months whereas the complete success rate was 46% and 40% at 12 and 24 months, respectively. Complications occurred in 7 patients.

Conclusions:
Implantation of the eW system effectively lowered IOP and reduced glaucoma medications for a 2-year period in patients who had previously failed glaucoma surgery. Persistent hypotony was not observed and the number of complications was low.
A Survey of the Prevalence of Impostor Phenomenon Among US Entry-Level Doctor of Physical Therapy Students
Authors: Young Allison , Handlery Kaci , Kahl Dana , Handlery Reed , James Dawn 
Published: November 2023

Introduction.
Individuals experiencing impostor phenomenon (IP) report feelings of intellectual phoniness and are unable to internalize their successes. Students experiencing IP may incur barriers to success in their educational and professional careers. The purpose of this study was to investigate the prevalence of IP in entry-level, physical therapist (PT) education programs in the United States.

Review of the Literature.
The prevalence of IP among other students of health care professions has been established. No previous study has investigated the prevalence of IP in Doctor of Physical Therapy (DPT) students.

Subjects.
Five hundred ninety-three US-based, entry-level, DPT students were recruited in the study.

Methods.
An anonymous, electronic survey of demographic data and the Clance Impostor Phenomenon Scale (CIPS) were distributed. Doctor of Physical Therapy students who scored ≥ 62 on the CIPS demonstrated feelings of IP.

Results.
Four hundred thirty-nine (74.03%) respondents demonstrated feelings of IP. Female students (78.9%) experienced greater feelings of IP than male students (59.7%). A smaller proportion of African Americans (59%) demonstrated feelings of IP compared with students of other races (75.1%), although this association was no longer significant when considering gender.

Discussion and Conclusion.
Nearly three-quarters of the DPT students enrolled in US-based, entry-level PT education programs who participated in this study met the criteria for IP, with female students more likely to report IP compared with male students. Doctor of Physical Therapy students reported lack of resources or decreased awareness of resources to support IP. Physical therapist education programs should consider identifying students with IP and develop methods to support student success.
Immunological outcomes of autologous hematopoietic stem cell transplantation for multiple sclerosis: a systematic review
Authors: Sai Santhosha Mrudula Alla , Avula Naga L.P. , Ahmed Sanah Kauser , Salian Rishabh B. , Alla Deekshitha , Jagannath Preethi , Polasu Sri S.S.P. , Rudra Pranathi , Issaka Yussif , Khetan Moksh S. , Gupta Trisha 
Published: November 2023

Background:
Autologous hematopoietic stem cell transplantation (AHSCT) is an extensive procedure that allows for the depletion of the immune system and its restoration from hemopoietic stem cells. The approach has been modified for the treatment of severe immune-mediated illnesses, including multiple sclerosis (MS), after being initially devised for the treatment of hematological malignancies.

Objective:
This systematic review aims to determine and consolidate the information on the short-term and long-term immunological effects of AHSCT on the cellular level in MS patients.

Methods:
The PubMed, Scopus, and Web of Science servers were used to conduct a systematic search in compliance with the PRISMA guidelines. The results were tabulated and analyzed.

Results:
A total of 17 studies (10 clinical trials, 6 cohort studies, and 1 case–control study) were included in the final analysis, and 383 MS patients were analyzed. A significant decline in the cell count of CD4 T cells was reported when compared to the CD8 T cells, B cells, and NK cells. B cell count returned to baseline in 71.4% of the studies at the end of 6 months. The NK cell count was found to be above the baseline in 62.5% of studies.

Conclusion:
AHSCT has been proven to be one of the most effective treatment modalities for MS in recent studies. However, debilitating complications due to immunological outcomes of the procedure have led to increased morbidity. Further research into this domain will help boost the success rate and efficacy of AHSCT.
MicroRNAs (miRNAs) role in hypertension: pathogenesis and promising therapeutics
Authors: Shaheen Nour , Shaheen Ahmed , Diab Rehab Adel , Desouki Mariam Tarek 
Published: November 2023

Background:
MicroRNAs (miRNAs) are small, non-coding RNA molecules that play a crucial role in regulating various cellular processes, including cell proliferation, differentiation, apoptosis, and disease development. Recent studies have highlighted the importance of miRNAs in the development and progression of essential hypertension, a common form of high blood pressure that affects millions of individuals worldwide. The molecular mechanisms by which miRNAs regulate hypertension are complex and multifaceted. MiRNAs target the 3’ untranslated regions of mRNA molecules, thereby regulating the synthesis of specific proteins involved in cardiovascular function. For instance, miRNAs are known to regulate the expression of genes involved in blood vessel tone, cardiac function, and inflammation. The growing body of research on miRNAs in hypertension has highlighted their potential as therapeutic targets for managing this condition. Studies have shown that miRNA-based therapies can modulate the expression of key genes involved in hypertension, leading to improvements in blood pressure and cardiovascular function. However, more research is needed to fully understand the mechanisms of miRNA-mediated hypertension and to develop effective therapeutic strategies.

Conclusions:
In summary, this review highlights the current understanding of the role of miRNAs in essential hypertension, including their molecular mechanisms and potential therapeutic applications. Further research is needed to fully understand the impact of miRNAs on hypertension and to develop new treatments for this common and debilitating condition.
Meningitis in Niger Republic amidst COVID-19: current issues and novel recommendations
Authors: Oduoye Malik Olatunde , Akanbi-Hakeem Hauwa Bolanle , Muzammil Muhammad Ali , Arama Umulkhairah Onyioiza , Abbasi Haleema Qayyum , Farhan Kanza , Fariha FNU , Modupeoluwa Olajide O. , Paul Houessou W. , Badarou Achiraf-deen E. , Akilimali Aymar 
Published: November 2023

Amidst coronavirus disease 2019 (COVID-19), there has been a misplaced priority on meningitis in the Niger Republic, thus refocusing resources and attention away from the continuing meningitis campaign in the Niger Republic. The over-strained state of public health resources and staff has also led to decreased surveillance, postponed diagnoses, and constrained immunization efforts in Niger Republic. This review aims to bridge the gaps regarding meningitis amid COVID-19 in Niger Republic and offer recommendations to government to mitigate meningitis in the country, with the hope of finding a permanent solution to this debilitating disease. The authors reviewed 45 past and present pieces of literature on meningitis and COVID-19 from 2013 to 2023 in well-renowned scientific databases such as PubMed, ResearchGate, Google Scholar, African Journals Online, Medline, and Embase. Since 2015, Niger Republic has experienced multiple meningitis epidemics that have resulted in 20, 789 cases and 1, 369 deaths [a case fatality rate (CFR) of 6.6%]. A total of 231 cases of meningitis were reported from 1 November 2021 to 31 January 2022. And recently, 559 cases of meningitis (of which 111 are laboratory confirmed), including 18 deaths (overall CFR 3.2%), occurred in the Zinder region, southeast of Niger Republic, from 1 November 2022 to 27 January 2023. Meningitis remains a public health concern in the world, especially in Niger Republic, which could lead to serious long-term complications. Therefore, adequate and novel measures and therapeutic actions should be implemented by the Niger Government to lessen the burden of the disease in the country.
Complete androgen insensitivity syndrome diagnosed after inguinal surgery in era of modern technology: a case report
Authors: Shrestha Anup , Thapa Anup , Bohara Keshav , Simkhada Suman 
Published: November 2023

Introduction:
Androgen Insensitivity Syndrome (AIS) is a rare X-linked recessive disorder of sexual development. It results from mutations in the Androgen Receptor (AR) gene located on chromosome Xq11–12. Affected individuals have a male genotype but a female phenotype.

Case presentation:
A 20-year-old female presented to the emergency room with a history of pain in the bilateral inguinal region. In ultrasonography (USG), bilateral inguinal hernia was suspected. While performing an emergency operation for hernia repair, hernia was revealed as bilateral abdominal testis. Then, after a gynecology consultation, a bilateral orchidectomy was done. Postoperative karyotyping showed a male genotype. Then the patient was discharged on hormone replacement therapy to maintain normal bone mineral density and secondary sexual characteristics.

Discussion:
AIS presents with primary amenorrhea in pubertal females. The growth spurt and secondary sexual characteristics are normal except for absent axillary and pubic hair. There is a short-blind vagina, but the uterus is absent, and the abdominal testis presents as an inguinal hernia. Serum gonadotropin level, karyotyping, and imaging studies are done to reach a diagnosis. Management includes gonadectomy, genitoplasty, and hormone replacement therapy.

Conclusion:
The objective of this report was to make clinicians aware that AIS can present as a bilateral inguinal hernia. In acute presentations, it can be misdiagnosed as a strangulated femoral hernia only later to be identified as an undescended abdominal testis during surgery. An absence of proper clinical judgment and reliance on USG for imaging can often lead to misdiagnosis in acute settings.
Diagnosis of a pulmonary hydatid cyst by fine needle aspiration: a case report with literature review
Authors: Abdullah Ari M. , Rashid Rezheen J. , Tahir Soran H. , Fattah Fattah H. , Hama Jihad Ibrahim , Abdullah Hiwa O. , Kakamad Suhaib H. , Kakamad Fahmi H. , Abdalla Berun A. 
Published: November 2023

Introduction and importance:
Hydatid cysts are seldom identified in cytologic smears and are often incidental. This report highlights a case where fine needle aspiration cytology was unintentionally utilized to diagnose a pulmonary hydatid cyst clinically mistaken for an abscess.

Case presentation:
A 29-year-old female presented with intermittent respiratory symptoms, including a mild cough and sputum, that she has been complaining of since 2020. A blood investigation revealed an elevated erythrocyte sedimentation rate (25 mm/h), C-reactive protein (>5 mg/dl), and white blood cells (>11×109/l). A high-resolution computed tomography scan of the chest revealed an irregular pulmonary opacity in the right lower lobe with central fluid attenuation, suspecting an abscess or, less likely, a pulmonary neoplasm. The patient underwent fine needle aspiration cytology, which was diagnosed as a hydatid cyst. A thoracotomy was performed, and the cyst was totally excised. Histopathological results of the specimen confirmed the previous diagnosis.

Clinical discussion:
Various diagnostic modalities have been discussed for diagnosing hydatid cysts, including radiology, serology tests, and fine needle aspiration. These modalities have been evaluated in terms of their respective advantages and drawbacks.

Conclusion:
Hydatid cysts can be challenging to diagnose based on imaging findings and may be misidentified as abscesses or masses. Despite the risk of anaphylaxis, fine needle aspiration cytology can be a reliable diagnostic method if performed meticulously by experienced radiologists.
Impact of Immune Checkpoint Inhibitor Therapy on Quality of Life in Patients With Advanced Melanoma
Authors: Jackson-Carroll Natalie , Whisenant Meagan , Crane Stacey , Johnson Constance 
Published: November 2023

Background
Immune checkpoint inhibitors (ICIs) were approved to treat advanced melanoma (AM) because of meaningful clinical benefit. These early data reported that ICI therapy is generally well tolerated, and despite symptoms, patients reported a high global health-related quality of life (HRQOL).

Objective
Immune checkpoint inhibitors are widely used in the oncology community; the aim of this systematic review was to evaluate current data on ICI therapy and its impact on HRQOL of patients with AM.

Methods
The Preferred Reporting Items for Systematic Reviews and Meta-Analyses guidelines were followed during this systematic review to identify and select studies from the PubMed, OVID, EMBASE, and Cochrane databases. Selected studies were downloaded into Covidence and analyzed for trends in how ICI therapy impacts HRQOL in patients with AM. Multiple tools were used to assess the quality of the studies.

Results
The 16 studies included 12 quantitative, 2 qualitative, and 2 mixed-methods studies. The quality of the studies was moderate (n = 7) or strong (n = 9). Symptoms that impacted HRQOL were fatigue, endocrine dysfunction, rash, diarrhea, cognitive impairment, emotional impact (anxiety and depression), and financial toxicity. Suicidal ideation and 1 attempt were reported in 2 studies, which had not been previously published.

Conclusion
Patient-reported symptoms due to ICI negatively impacted HRQOL. Anxiety and depression are prevalent. Current QOL instruments do not capture the entire patient experience.

Implications for Practice
Patients need to be asked if their symptoms are impacting their HRQOL. Further prospective research is needed to develop or adjust current patient-reported outcome instruments to adequately capture the impact of ICIs on HRQOL.
Incidental Detection of 68Ga-DOTA-RGD-2 Uptake in Uterine Fibroid
Authors: Solanki Ritanshu , Mittal Bhagwant Rai , Kumar Rajender , Singh Harmandeep , Sharma Aman 
Published: November 2023

Abstract
Uterine fibroids are benign tumors originating from the smooth muscle cells of the myometrium seen in approximately 20%–50% of women of reproductive age. The Arg-Gly-Asp (RGD) binds to αvβ3 integrin expressed on the surface of angiogenic blood vessels or tumor cells. 18F-FDG PET/CT has been used to evaluate uterine fibroids, with moderate 18F-FDG uptake. However, angiogenesis imaging in uterine fibroids has not been evaluated. The present case presents a rare finding of RGD uptake in the uterine fibroid on 68Ga-DOTA-RGD-2 PET/CT in a patient who underwent angiogenesis imaging for left ankle joint pain and swelling.
Colorectal Adenocarcinoma Mimicking Neuroendocrine Neoplasia on 18F-FDOPA PET/CT
Authors: Moreau Aurélie , Isnardi Vanina , Mognetti Thomas , Meurgey Alexandra , Kryza David 
Published: November 2023

Abstract
We present a case of a 48-year-old woman who had previously undergone surgical resection for bladder paraganglioma. An 18F-FDOPA PET/CT scan performed for suspected colorectal paraganglioma showed intense colorectal uptake associated with adenopathy. Histological examination did not support the presence of a neuroendocrine tumor but instead confirmed the presence of moderately differentiated colorectal adenocarcinoma. Colorectal adenocarcinoma belongs to the list of nonneuroendocrine false-positive tumors that can be detected using 18F-FDOPA. Therefore, a morphological analysis is important. Thus, 18F-FDOPA may be a marker for the aggressiveness of colorectal adenocarcinoma.
“Wandering Spleen” With Lymphomatous Involvement
Authors: Cagliyan Feyza , Balaban Genc Zeynep Ceren , Dede Fuat , Erdil Tanju Yusuf 
Published: November 2023

Abstract
Wandering spleen is a rare condition caused by either lack or the laxity of ligaments, which results malposition in the lower abdomen or pelvis. FDG PET/CT is the cornerstone of the staging procedures in the management of lymphomas leading to upstaging and picking up occult lesions in the spleen and extranodal sites. Herein, we reported initial staging 18F-FDG PET/CT findings of a woman with Hodgkin lymphoma whose spleen was absent in normal position and multiple intense heterogenous hypermetabolism in a pelvic mass raised a suspicion of wandering splenic involvement. The confirmation was made with selective spleen SPECT/CT images thereafter.