bluuebunny/crossref_metadata_2025_split huggingface dataset:
Adolescent Simulation in a Health Assessment Course for Advanced Practice Nursing Students
Authors: Edgar Carly , Young Cara C. , Cuevas Heather 
Published: January 2024

Abstract
Advanced practice registered nurse (APRN) students face challenges transitioning to practice. They benefit greatly from simulated learning experiences that build confidence and increase competence in the skills needed to perform in an APRN role. The purpose of this quality improvement project was to evaluate the effectiveness of a simulated adolescent well visit in an advanced health assessment course. Using a pretest/posttest design, qualitative and quantitative data were collected from participants. Results included high learner satisfaction, an increase in both self-reported competence and confidence, and an appreciation for the “safe space” of learning.
Exploring the Effectiveness of a Prenursing Introductory Course: Experiences of Culturally Diverse Nursing Students
Authors: Griffin Miriam L. 
Published: January 2024

Abstract
Greater ethnic and racial diversity in the nursing profession is needed to reduce health care disparities and provide culturally competent health care to an increasingly diverse patient population. Prenursing preparation and early intervention programs have been developed to reduce attrition among culturally diverse students. A basic qualitative study was conducted to answer how culturally diverse students describe their experiences in a prenursing introductory course, part of a rigorous bachelor of nursing program at a historically Black university. An inductive thematic analysis revealed that students considered the course too easy; the course contributed to first-semester success.
Improvements in Objective and Patient-Reported Measures of Physical Function Following an 8-Week Exercise Oncology Program
Authors: Brooks Alexander M. , Fairman Ciaran M. , Harrington Shana E. 
Published: January 2024

Background:
Physical function is often impaired because of cancer and its treatment. Despite this, it is not common to comprehensively assess physical function in clinical practice. The purpose of this study was to examine the changes in objective and patient-reported physical function in adults with a history of cancer who completed an exercise program.

Methods:
The program was offered 2 d/wk for 8 weeks at an outpatient physical therapy clinic and consisted of resistance and aerobic exercises that were individualized to each participant. Objective physical function was assessed using the Bellarmine Norton Assessment Tool consisting of self-reported physical activity frequency, 2-minute step test, 30-second sit to stand, timed arm curl, Timed Up and Go, and scaled total score. Patient-reported physical function was assessed using the PROMIS-Physical Function (PF) Computerized Adaptive Test (CAT).

Results:
Significant differences (P < .001) were found for all outcomes demonstrating improvements in objective and patient-reported physical function. Changes in raw and scaled total score for objective physical function displayed large Cohen d effect sizes (ES), physical activity (ES = 0.82), 2-minute step test (ES = 1.00), 30-second sit to stand (ES = 1.01), arm curl (ES = 1.01), Timed Up and Go (ES = 0.85), and scaled total score (ES = 1.31). Changes in PROMIS-PF CAT demonstrated a medium-large effect (ES = 0.78).

Conclusion:
The effectiveness of the exercise program was supported by significant improvements in objective and patient-reported physical function. The use of such outcomes provides a useful method to understand changes in physical function and supports the development of effective exercise methods for survivors of cancer.
Prospective Single-Arm Feasibility of Supervised Virtual Exercise in Women Living with Ovarian Cancer: The BE-BALANCED Study
Authors: Fujita Rafael A. , Tinker Anna , Fujisawa Natalie , Holmes Andrea , Hanley Gillian E. , Mackey Dawn C. , Trinh Linda , Lesser Iris , Mackenzie Kelly A. , Larnder Ashley , Murphy Rachel A. , Smith Gillian V. H. , Lam Jee A. , Campbell Kristin L. 
Published: January 2024

Background:
Access to exercise programming that addresses the unique needs of women living with and beyond ovarian cancer is limited. Feasible and accessible supportive care programs to enhance physical function and quality of life are needed. We aimed to assess the feasibility of a 12-week virtually delivered exercise program for women living with and beyond ovarian cancer.

Methods:
BE-BALANCED was a prospective single-arm feasibility pilot study. Women who had completed primary chemotherapy treatment of ovarian cancer within the past year were recruited through oncologist referrals or self-referral. The 12-week group exercise program targeting aerobic capacity, functional strength, balance, and range of motion was conducted virtually twice weekly using Zoom. Feasibility measures were accrual, attendance, adherence, and attrition. Physical function was evaluated using the Short Physical Performance Battery and selected components of the Senior Fitness Test.

Results:
Fourteen participants enrolled in the study (47% of the accrual target). Feasibility goals for the exercise sessions were met for attendance (84% ± 19%), adherence to virtual sessions (78% ± 19%), and fidelity of group belonging (18% ± 4%), and met for overall attrition (21%). Improvements were observed in gait speed, 30-second bicep curls, 6-minute walk, chair stand, and emotional well-being (P < .05). Participant satisfaction with the program was high (4.4/5).

Conclusion:
Our findings demonstrated the feasibility of a virtually delivered exercise program for women living with and beyond ovarian cancer, with favorable attendance, adherence, and safety data. The program showed potential in improving physical outcomes and quality of life for participants. However, recruitment was a challenge. Future interventions could consider different approaches to increase recruitment.
Evaluation and Management of Buprenorphine Extended-Release Injection Thrombophlebitis: A Case Report
Authors: Barrett John , Schapiro Rebecca , Casey Emily , Chertok Judy 
Published: January 2024

Introduction
Buprenorphine extended-release subcutaneous injection (BUP-XR) is a medication used to treat opioid use disorder. It is a long-acting formulation of buprenorphine, which is a partial opioid agonist. Buprenorphine extended-release subcutaneous injection is injected into the subcutaneous space forming a depot that can last up to a month. The most common adverse effects of BUP-XR are injection site pain, erythema, and induration.

Case Report
A man in his late 30s presented to the emergency department 48 hours after BUP-XR injection with abdominal pain. He was found to have superficial venous thrombosis of an abdominal wall vessel extending near the deep venous system. He was subsequently started on apixaban for 30 days and cefadroxil for 7 days to reduce the risk of extension and infection. He fully recovered and has since restarted BUP-XR without further complications.

Conclusions
Venous thrombosis is a rare but potentially life-threatening complication of BUP-XR. It is important for emergency and outpatient clinicians to be aware of adverse reactions associated with this medication. The patient was successfully treated with a 30-day course of apixaban and able to resume taking BUP-XR without further complications. Clinicians may want to consider supplementing BUP-XR with sublingual film after injection-related complications due to possible lower serum levels.
Revisiting Post-ICU Admission Fluid Balance Across Pediatric Sepsis Mortality Risk Strata: A Secondary Analysis of a Prospective Observational Cohort Study
Authors: Atreya Mihir R. , Cvijanovich Natalie Z. , Fitzgerald Julie C. , Weiss Scott L. , Bigham Michael T. , Jain Parag N. , Abulebda Kamal , Lutfi Riad , Nowak Jeffrey , Thomas Neal J. , Baines Torrey , Quasney Michael , Haileselassie Bereketeab , Sahay Rashmi , Zhang Bin , Alder Matthew N. , Stanski Natalja L. , Goldstein Stuart L. 
Published: January 2024

OBJECTIVES:
Post-ICU admission cumulative positive fluid balance (PFB) is associated with increased mortality among critically ill patients. We sought to test whether this risk varied across biomarker-based risk strata upon adjusting for illness severity, presence of severe acute kidney injury (acute kidney injury), and use of continuous renal replacement therapy (CRRT) in pediatric septic shock.

DESIGN:
Ongoing multicenter prospective observational cohort.

SETTING:
Thirteen PICUs in the United States (2003–2023).

PATIENTS:
Six hundred and eighty-one children with septic shock.

INTERVENTIONS:
None.

MEASUREMENTS AND MAIN RESULTS:
Cumulative percent PFB between days 1 and 7 (days 1–7 %PFB) was determined. Primary outcome of interest was complicated course defined as death or persistence of greater than or equal to two organ dysfunctions by day 7. Pediatric Sepsis Biomarker Risk Model (PERSEVERE)-II biomarkers were used to assign mortality probability and categorize patients into high mortality (n = 91), intermediate mortality (n = 134), and low mortality (n = 456) risk strata. Cox proportional hazard regression models with adjustment for PERSEVERE-II mortality probability, presence of sepsis-associated acute kidney injury on day 3, and use of CRRT, demonstrated that time-dependent variable days 1–7%PFB was independently associated with an increased hazard of complicated course. Risk-stratified analyses revealed that each 10% increase in days 1–7 %PFB was associated with increased hazard of complicated course only among patients with high mortality risk strata (adjusted hazard ratio 1.24 (95% CI, 1.08–1.43), p = 0.003). However, this association was not causally mediated by PERSEVERE-II biomarkers.

CONCLUSIONS:
Our data demonstrate the influence of cumulative %PFB on the risk of complicated course in pediatric septic shock. Contrary to our previous report, this risk was largely driven by patients categorized as having a high mortality risk based on PERSEVERE-II biomarkers. Incorporation of such prognostic enrichment tools in randomized trials of restrictive fluid management or early initiation of de-escalation strategies may inform targeted application of such interventions among at-risk patients.
Duloxetine improves chronic orofacial pain and comorbid depressive symptoms in association with reduction of serotonin transporter protein through upregulation of ubiquitinated serotonin transporter protein
Authors: Nakamura Mariko , Yoshimi Akira , Tokura Tatsuya , Kimura Hiroyuki , Kishi Shinichi , Miyauchi Tomoya , Iwamoto Kunihiro , Ito Mikiko , Sato-Boku Aiji , Mouri Akihiro , Nabeshima Toshitaka , Ozaki Norio , Noda Yukihiro 
Published: January 2024

Abstract
Chronic orofacial pain (COP) is relieved by duloxetine (DLX) and frequently causes depressive symptoms. The aim of this study was to confirm effects of DLX on pain and depressive symptoms, and to associate with their effectiveness in platelet serotonin transporter (SERT) expression, which is a target molecule of DLX and plasma serotonin concentration in COP patients with depressive symptoms. We assessed for the severity of pain and depressive symptoms using the Visual Analog Scale (VAS) and 17-item Hamilton Depression Rating Scale (HDRS), respectively. Chronic orofacial pain patients were classified into 2 groups based on their HDRS before DLX-treatment: COP patients with (COP-D) and without (COP-ND) depressive symptoms. We found that the VAS and HDRS scores of both groups were significantly decreased after DLX treatment compared with those before DLX treatment. Upregulation of total SERT and downregulation of ubiquitinated SERT were observed before DLX treatment in both groups compared with healthy controls. After DLX treatment, there were no differences in total SERT of both groups and in ubiquitinated SERT of COP-D patients compared with healthy controls; whereas, ubiquitinated SERT of COP-ND patients remained downregulated. There were positive correlations between changes of serotonin concentrations and of VAS or HDRS scores in only COP-D patients. Our findings indicate that DLX improves not only pain but also comorbid depressive symptoms of COP-D patients. Duloxetine also reduces platelet SERT through upregulation of ubiquitinated SERT. As the result, decrease of plasma serotonin concentrations may be related to the efficacy of DLX in relieving pain and depression in COP patients.
An improved conflict avoidance assay reveals modality-specific differences in pain hypersensitivity across sexes
Authors: Ferland Samuel , Wang Feng , De Koninck Yves , Ferrini Francesco 
Published: January 2024

Abstract
Abnormal encoding of somatosensory modalities (ie, mechanical, cold, and heat) are a critical part of pathological pain states. Detailed phenotyping of patients' responses to these modalities have raised hopes that analgesic treatments could one day be tailored to a patient's phenotype. Such precise treatment would require a profound understanding of the underlying mechanisms of specific pain phenotypes at molecular, cellular, and circuitry levels. Although preclinical pain models have helped in that regard, the lack of a unified assay quantifying detailed mechanical, cold, and heat pain responses on the same scale precludes comparing how analgesic compounds act on different sensory phenotypes. The conflict avoidance assay is promising in that regard, but testing conditions require validation for its use with multiple modalities. In this study, we improve upon the conflict avoidance assay to provide a validated and detailed assessment of all 3 modalities within the same animal, in mice. We first optimized testing conditions to minimize the necessary amount of training and to reduce sex differences in performances. We then tested what range of stimuli produce dynamic stimulus–response relationships for different outcome measures in naive mice. We finally used this assay to show that nerve injury produces modality-specific sex differences in pain behavior. Our improved assay opens new avenues to study the basis of modality-specific abnormalities in pain behavior.
Healthy women show more experimentally induced central sensitization compared with men
Authors: Guekos Alexandros , Saxer Janis , Salinas Gallegos Diego , Schweinhardt Petra 
Published: January 2024

Abstract
Women more often experience chronic pain conditions than men. Central sensitization (CS) is one key mechanism in chronic pain that can differ between the sexes. It is unknown whether CS processes are already more pronounced in healthy women than in men. In 66 subjects (33 women), a thermal CS induction protocol was applied to the dorsum of one foot and a sham protocol to the other. Spatial extent [cm2] of secondary mechanical hyperalgesia (SMH) and dynamic mechanical allodynia were assessed as subjective CS proxy measures, relying on verbal feedback. Changes in nociceptive withdrawal reflex magnitude (NWR-M) and response rate (NWR-RR) recorded through surface electromyography at the biceps and rectus femoris muscles were used as objective CS proxies. The effect of the CS induction protocol on SMH was higher in women than in men (effect size 2.11 vs 1.68). Nociceptive withdrawal reflex magnitude results were statistically meaningful for women (effect size 0.31-0.36) but not for men (effect size 0.12-0.29). Differences between men and women were not meaningful. Nociceptive withdrawal reflex response rate at the rectus femoris increased in women after CS induction and was statistically different from NWR-RR in men (median differences of 13.7 and 8.4% for 120 and 140% reflex threshold current). The objective CS proxy differences indicate that dorsal horn CS processes are more pronounced in healthy women. The even larger sex differences in subjective CS proxies potentially reflect greater supraspinal influence in women. This study shows that sex differences are present in experimentally induced CS in healthy subjects, which might contribute to women's vulnerability for chronic pain.
A Comparison of Functional Luminal Imaging Probe With High-resolution Manometry, Timed Barium Esophagram, and pH Impedance Testing to Evaluate Functional Luminal Imaging Probe’s Diagnostic Capabilities
Authors: Miller James D. , Kemple Brendan P. , Evans Joni K. , Clayton Steven B. 
Published: January 2024

Objective:
The aims of this study are to determine the functional luminal imaging probe’s (FLIP) diagnostic utility by comparing FLIP measurements with results from other esophageal evaluation standards.

Background:
The FLIP is an esophageal evaluation technique performed at the time of endoscopy. Few studies have evaluated FLIP diagnostic capabilities compared with the established testing techniques, including high-resolution manometry (HRIM), time barium esophagram (TBE), and 24-hour impedance-pH monitoring.

Patients and Methods:
A retrospective review was performed for 413 preintervention patients who underwent FLIP testing during endoscopy. Data from HRIM, 24-hour pH monitoring, and TBE were compared.

Results:
Abnormal Distensibility Index (DI) was associated with abnormal integrated relaxation pressure (IRP; P = 0.003). Average DI was higher in patients with abnormal IRP (>15 mm Hg) when a hiatal hernia was present (P = 0.025). The total agreement between correlated diagnoses from FLIP and HRIM was 33.5%. DI was not associated with acid exposure time on pH monitoring. Agreement between FLIP and TBE was 49% with a sensitivity of 98.1% and a specificity of 36.5%. A 60 mL distension had a significantly lower detection rate than 40 mL and 50 mL for active peristalsis and was unaffected by pressure (P < 0.05).

Conclusions:
FLIP as an adjunct to HRIM is supported by strong metric correlation. FLIP was not correlated to pH monitoring findings, suggesting FLIP is not useful in reflux assessment. The agreement between FLIP and TBE was lower than in previous studies. Hiatal hernia impacted the normality between DI and IRP, not between FLIP and TBE. We suggest analyzing peristaltic patterns on panometry at all fill volumes to optimize detection.
Diagnostic Yield of Small Bowel Videocapsule Endoscopy in Patients with Iron Deficiency Anemia. A Systematic Review and meta-analysis
Authors: Rossi Roberta Elisa , Zullo Angelo , Ferretti Silvia , Migliorisi Giulia , Gatta Luigi , De Francesco Vincenzo , Del Forno Alessandro , Marcozzi Giacomo , Masoni Benedetta , Franchellucci Gianluca , Hassan Cesare , Repici Alessandro 
Published: January 2024

Background and Aim:
Gastrointestinal (GI) bleeding or malabsorption represents the most frequent aetiologies of iron deficiency anemia (IDA). The cause of IDA remains undetermined in ~10% to 20% of patients undergoing upper and lower GI endoscopies. In this scenario, a small bowel examination with videocapsule endoscopy (VCE) is recommended. We performed a systematic review with meta-analysis to evaluate the diagnostic yield of VCE in patients with IDA without overt bleeding, assessing the prevalence of either any lesion or lesions at high potential of bleeding.

Materials and Methods:
A computerized literature search was performed using relevant keywords to identify all the pertinent articles published until March 2023.

Results:
Twelve studies with a total of 1703 IDA patients (Males: 47%; age range: 19-92 y) were included in this systematic review. The diagnostic yield of VCE for overall lesions in the small bowel was 61% (95% CI=44-77; 95 CI=97.2-98.1; I
2=97.7%). When analyzing only small bowel lesions likely responsible of IDA, the diagnostic yield was 40% (95% CI=27-53; 95% CI=95.3-97; I
2=96.3%).

Conclusion:
VCE plays a relevant role in the diagnostic work-up of patients with IDA without overt bleeding with a satisfactory diagnostic yield.
The role of chest computed tomography in the evaluation and management of chronic obstructive pulmonary disease
Authors: Burkes Robert M. , Zafar Muhammad A. , Panos Ralph J. 
Published: January 2024

Purpose of review
The purpose of this review is to compile recent data on the clinical associations of computed tomography (CT) scan findings in the literature and potential avenues for implementation into clinical practice.

Recent findings
Airways dysanapsis, emphysema, chronic bronchitis, and pulmonary vascular metrics have all recently been associated with poor chronic obstructive pulmonary disease (COPD) outcomes when controlled for clinically relevant covariables, including risk of mortality in the case of emphysema and chronic bronchitis. Other authors suggest that CT scan may provide insight into both lung parenchymal damage and other clinically important comorbidities in COPD.

Summary
CT scan findings in COPD relate to clinical outcomes. There is a continued need to develop processes to best implement the results of these studies into clinical practice.
Predictors for Super-Responders in Cardiac Resynchronization Therapy
Authors: Vătășescu Radu Gabriel , Târtea Georgică Costinel , Iorgulescu Corneliu , Cojocaru Cosmin , Deaconu Alexandru , Badiul Alexandru , Goanță Emilia-Violeta , Bogdan Ștefan , Cozma Dragoș 
Published: January 2024

Background:
Prediction of cardiac resynchronization therapy (CRT) response, particularly a super-response, is of great importance.

Study Question:
The aim of our study was to assess the predictors for super-responders in CRT.

Study Design:
We conducted a retrospective, observational study, which finally included 622 patients with heart failure treated with CRT between January 2008 and May 2020 who had a minimal follow-up of 6 months after CRT.

Measures and Outcomes:
A total of 192 super-responders, defined by a left ventricular ejection fraction (LVEF) of at least 45%, and/or minimum 15% increase in LVEF and an improvement of the New York Heart Association functional class by at least 2 degrees at the last follow-up, and the rest of 430 patients who did not fulfill the super-responder criteria.

Results:
The highest rate of super-responders (41.91%, n = 171) was at patients with left ventricle-only pacing with optimal fusion (OPT) compared with patients with biventricular (BiV) pacing (9.81%, n = 21, P < 0.000). In the OPT group, univariable analysis showed that nonischemic cardiomyopathy, a smaller degree of mitral regurgitation, and better left ventricle function at enrollment were predictors for super-response compared with the BiV group where a narrower QRS after implantation, nonischemic cardiomyopathy, and a better baseline LVEF were predictors for super-responders. In the multivariable analysis, both narrower QRS after implantation and nonischemic cardiomyopathy were independent predictors for super-response in the BiV group compared with OPT where nonischemic cardiomyopathy remained the only independent predictor for super-response.

Conclusions:
In this retrospective study, OPT CRT programing was an additional predictor of super-response to CRT besides nonischemic cardiomyopathy.