bluuebunny/crossref_metadata_2025_split huggingface dataset:
Normothermic ex vivo heart and lung autoperfusion: assessment of functional status and metabolism
Authors: Tarkova A. R. , Zykov I. S. , Zhulkov M. O. , Protopopov A. V. , Smirnov Ya. M. , Makaev A.  G. , Guseva A. V. , Kosimov F. Yu. , Murtazaliev M. N. , Limansky A. D. , Sirota D. A. , Kliver E.  E. , Kliver V. E. , Volkov А. M. , Chernyavsky A. M. 
Published: January 2024

Objective: to carry out a comparative study of the efficacy of a 6-hour normothermic ex vivo heart and lung autoperfusion and cold cardioplegia using Bretschneider’s solution (Custodiol®, Germany).Materials and methods. Landrace pigs weighing 50 ± 5 kg at the age of 4–5 months (n = 10) were used as a model for a series of acute experiments. In the experimental group (n = 5), the cardiopulmonary complex was conditioned by autoperfusion for 6 hours. In the control group, the heart pumping function was restored after 6-hour cold cardioplegia using Bretschneider’s solution. The efficiency of graft preservation was assessed by measuring hemodynamic parameters, myocardial contractile function, and myocardial oxygen consumption.Results. After reperfusion and repeated isolation of the working cardiopulmonary complex, cardiac output was 0.63 [0.37; 0.8] L/min and 0.37 [0.23; 0.37] L/min in the experimental and control groups, respectively (p < 0.05). Indicators – global left ventricular stroke work index and preload recruitable stroke work – were significantly higher in the experimental group (p < 0.05).Conclusion. Normothermic autoperfusion is significantly more effective in preserving the morphofunctional status of a donor heart than static cold storage with Bretschneider solution for 6 hours.
Safety assessment of the femtosecond laser in corneal limbal graft excision
Authors: Nefedova O. N. , Malyugin B. E. , Borzenok S. A. , Gerasimov M. Yu. , Ostrovsky D. S. , Shatskikh A.  V. 
Published: January 2024

Objective: to study in vitro survival and preservation of the proliferative activity of limbal stem cells (LSCs) in femtosecond laser-cut limbal tissue fragments. Materials and methods. Limbal fragments were formed from donor cadaver eyes (n = 8) in the upper and lower limbus containing the highest number of limbal stem cells, using a Z8 femtosecond laser (FSL) (Ziemer, Switzerland). The limbal fragments were fragmented into 4 mini-grafts using different energy levels (100, 110, 120%). Mini-grafts from symmetrical sections of the cadaver eyes, which were manually isolated using a microsurgical blade, served as controls. The mini-grafts were cultured for two weeks in culture media intended for limbal epithelial stem cells (LESCs) (Epilife (0.06 mM Ca++) and for multipotent mesenchymal stem cells (MMSCs) (DMEM/F12), with the addition of specific growth factors to selectively stimulate LESCs or MMSCs, respectively. The phenotype of the obtained cultured cells in the «laser» and «knife» groups was determined by flow cytometry using a set of markers (CD166, CD105, CD90, CD29, CD34) for the membrane proteins of LESCs and MMSCs. The ability of cultured cells to adhesion and proliferation in the «laser» and «knife» groups was determined by seeding the third passage of the resulting cultures on Bowman’s membrane of acellular corneas.Results. Primary cell culture was obtained from mini-grafts of all donors in both groups. Cell morphology was consistent with the phenotype of corneal epithelial cells (cobblestone pattern). When cultured in the EpiLife medium (0.06 mM Ca++), we determined the presence of LSCs proliferation from 38.6% of minigrafts; in the DMEM/F12 medium (1 : 1) the presence was determined from 31.8%. Two weeks later, cell yield from mini-grafts in the «laser» and «knife» groups was 77.2% and 63.6%, respectively. Cell growth by the end of week 2 of culturing of mini-grafts obtained by FSL at 120, 110 and 100% energies was 87.5, 71.4 and 71.4%, respectively. It was found that the resulting cell cultures in the «laser» and «knife» groups and in the «120%», «110%» and «100%» subgroups were not different phenotypically. Cytofluorimetric analysis showed that cell cultures in the groups had a mixed pattern of marker expression of both LESCs (CD29+) and MMSCs (CD90+, CD105+). Seeding of the third passage of cell culture in the test groups in all cases demonstrated adhesion and formation of a cell monolayer on the Bowman’s membrane of model corneas.Conclusion. The use of FSL for cutting out limbal grafts seems to be effective and safe in comparison with the traditional mechanical (knife) technique. Cell cultures obtained from FSL-cut mini-grafts were able to grow and migrate for at least 21 days.
Evaluation of hemostasis parameters in recipients following related transplantation of the right lobe of the liver
Authors: Babadjanov A. H. , Khaybullina Z. R. , Turgunbaev E. K. , Matkarimov Sh. U. 
Published: January 2024

Objective: to study the dynamics of hemostasis parameters in the early postoperative period and to identify the timing of restoration of the level of procoagulants and anticoagulants synthesized by the liver (received from a living related donor) in liver lobe recipients.Materials and methods. Under observation were 31 recipients and 31 related donors of liver lobe. They were treated at the Republican Specialized Scientific and Practical Medical Center for Surgery in Tashkent, Uzbekistan, from August 2022 to August 2023. Hemostasis parameters were determined in recipients, whose postoperative period was uneventful.Results. It was revealed that compensation in the hemostasis system occurs even at low levels of coagulation factors on day 10 after liver transplantation (LT). In recipients, a decrease in anticoagulants was more pronounced than that of procoagulants. In general, the hemostasis system was in an unstable equilibrium, which, under the influence of external and internal factors, can easily shift both towards hypercoagulable and hypocoagulable state. Activity of the fibrinolytic system and fibrinogen level are significant influencing factors. Gradual recovery of fibrinogen levels by the end of day 1 after surgery is the result of activation of the synthetic function of the liver. After LT, there were signs of endothelium activation, but not endothelial damage, which regress and normalize by postoperative day 10. At the same time, in the initial status, recipients had an increase in both the amount and activity of von Willebrand factor, which indicates endothelial damage and dysfunction. The low level of homocysteine in recipients is probably a protective factor against the development of thrombotic complications, and homocysteine dynamics reflects the gradual restoration of the functional activity of the liver, adaptation of the donor liver to functioning.Conclusion. Monitoring of hemostasis system in recipients after liver transplantation allows to prevent thrombohemorrhagic complications in time but also to assess the dynamic equilibrium of procoagulants and anticoagulants, the timing of restoration of the activity of the main hemostasis factors and, according to this, to vary the administration regimes of anticoagulants, antiplatelet medications, and fibrinolysis inhibitors, to carry out replacement therapy and to realize the concept of hemostasis management.
Студенты-медики и работа в «красной зоне» во время пандемии COVID-19: имеет ли религия значение?
Authors: Гузельбаева Гузель Яхиевна 
Published: January 2024

<p class="paragraph">Несколько лет пандемии COVID-19 внесли значительные изменения в сферу здравоохранения многих стран мира, а также в приоритетные представления о работе врача у населения и самих медицинских работников. На основе данных массового опроса и серии интервью, проведенных в 2022 г. на медицинских факультетах г. Москвы и г. Казани, данная статья демонстрирует, что некоторые, ранее периферийные, темы в научных исследованиях, касающихся работы врачей и среднего медицинского персонала, требуют научного анализа и осмысления. Речь идет о возросшей роли религиозного фактора не только в модели взаимоотношений «врач — пациент», но и на примере волонтерской работы и участия в деятельности «красных зон» для борьбы с COVID-19 как серьезной мотивации к профессии у студентов-медиков в целом.</p><p class="paragraph">Исследование продемонстрировало, что в мотивации поступления на медицинскую специальность студенты различаются в зависимости от их отношения к религии и вере. При том что подавляющее большинство студентов вне зависимости от религиозности видят цель своей работы прежде всего в желании помогать и лечить людей (77%), атеисты в большей степени, чем верующие, мотивированы такими целями в профессии, как зарабатывание медициной денег и карьерные устремления. Также религиозный фактор играет решающую роль для участия студентов-медиков в волонтерской работе — в ней задействованы 30% верующих и 18% атеистов. В практической деятельности на первый план выходит медицинский профессионализм и наличие навыков реальной работы с пациентами. Это было подтверждено положительным откликом на призыв государства помогать системе здравоохранения в периоды пика заболевания — участвовали в работе «красной зоны» в равной степени и верующие, и атеисты (по 24%).</p>
Анализ компетентности состава территориальной избирательной комиссии и участковой избирательной комиссии в процессе подготовки и проведения выборов в городском округе Щелково Московской области
Authors: Мельков Сергей Анатольевич , Забузов Олег Николаевич , Верницкий Герман Игоревич 
Published: January 2024

<p>В статье проанализированы уровни компетентности членов территориальной избирательной комиссии (ТИК) и участковой избирательной комиссии (УИК) в процессе подготовки и проведения выборов в городском округе Щелково Московской области.</p><p>В ходе проведенного исследования установлено, что члены УИК г. о. Щелково не в полной мере готовы к подготовке и проведению избирательных кампаний. Причины этого — достаточно низкая результативность работы Центра обучения членов избирательных комиссий и иных участников избирательного процесса при Избирательной комиссии Московской области, а также в целом низкая эффективность системы подготовки членов УИК.</p><p>Анализ результатов, полученных в ходе тестирования членов ТИК г. о. Щелково, показал, что степень компетентности членов ТИК примерно равна уровню компетенции членов УИК г. о. Щелково. Это подтверждает ранее выдвинутый тезис о низкой результативности курсов подготовки, проводимых Центром обучения членов избирательных комиссий и иных участников избирательного процесса при Избирательной комиссии Московской области. Вместе с тем анализ ответов членов ТИК на вопросы тестов приводит к выводу, что большинство неверных ответов дают члены ТИК, вошедшие в ее состав по представлению политических партий, что в совокупности с данными по посещению заседаний ТИК позволяют усомниться в результативности существующего механизма формирования ТИК и УИК.</p><p>Проведенное исследование мнений жителей г. о. Щелково по тематике электорального процесса позволяет заключить, что большая часть опрошенных не принимала участия в выборах Главы городского округа Щелково и состава Совета депутатов городского округа Щелково в 2019 г. Причинами этого стали низкая информированность жителей о проведении выборов и недоверие к результатам проведения выборов. В то же время не стоит списывать со счетов определенный уровень абсентеизма избирателей г. о. Щелково.</p><p>Основными методами исследования, используемыми при написании статьи, явились анкетирование и тестирование. В статье использованы данные Росстата.</p>
Assessment of severity of community acquired pneumonia by paediatric infectious diseases society and clinical and radiological profile in 0-5 year age group
Authors: Shukla Om Prakash , Rathwa Nikunj , Mude Lokesh Naik 
Published: January 2024

Background: The WHO estimates that ARI, mostly in the form of CAP, is the leading cause of death in children under five, killing over 2 million children annually. The present study's PEWS score and PIDS severity criteria were undertaken to know the clinical and radiological profile of patients with Pneumonia and to categorize these patients with PEWS score and PIDS criteria to redefine their severity and assess the management and outcomes.
Methods: Patients aged between 0 to 5 years who presented with cough complaints and respiration difficulty were assessed. The criteria for ICU admission is the presence of more than 2 minor criteria or one of the major criteria. PIDS criteria for CAP recommends ICU admission or continuous monitoring for children in ED.
Results: A prospective observational study of 104 children with CAP was included, and their pneumonia was evaluated using PIDS criteria. The patients were categorized for pneumonia according to PIDS criteria. 32.69% of children were classified as severe CAP (p value=0.02). This difference between non-severe and severe Pneumonia is considered to be statistically significant in which patients classified as severe CAP.
Conclusions: The patients were categorized for Pneumonia according to PIDS criteria. 32.69% of children were classified as severe CAP (p value=0.02). This difference between non-severe and severe Pneumonia is considered to be statistically significant in which patients classified as severe CAP needed vigorous management in emergency department followed by ICU management.
Clinical-epidemiological profile of vestibular migraine patients: Indian scenario
Authors: Joy Divya , Agarwal Ayushi , K. Rohit , Singh Sumit , Kakkar Vikas , Sharma Akriti , Arora Khushboo , Stani Anusha 
Published: January 2024

Background: The main objective of this study was to observe the Indian clinical scenario and analyse the clinical and epidemiological profile of patients with vestibular migraine.
Methods: This is a retrospective observational descriptive study. The outpatient records of the vertigo clinic at Department of Otorhinolaryngology of SGT medical college, Budhera, Gurgaon, Haryana was assessed from April 2023 to July 2023. Patients who were diagnosed with vestibular migraine based on ICD classification as follows was included in the study.
Results: Study population predominantly comprised of 77% (17) females and 23% (5) of males. Almost 80% of the study population belonged to age group 31-40 years. Each episode of vertigo lasts for seconds in 50% of the patients and minutes in 45% of the patients. All patients had episodic vertigo.59% of patients described the vertigo as rotatory,18 % of the study population reported imbalance,18 % described swaying and 5% reported blackouts. Most of the examination was normal except 5 out of 22 patients reported giddiness on testing vertical saccades.
Conclusions: Vestibular migraine is an underdiagnosed condition in India, there’s not much research and awareness, hence this study aims to overcome these limitations. Most of the patients were middle aged women. The physical and audiological examination of most patients were normal but showing abnormalities on testing saccades.
APLICAÇÃO DE EXTENSÃO DE NAVEGADOR DE INTERNET NA PLATAFORMA CURRÍCULO LATTES PARA OBTENÇÃO DE DADOS E ANÁLISE DE PONTUAÇÃO DE ARTIGOS PUBLICADOS EM PERIÓDICOS
Authors: Da Costa Renato Pinheiro , De Almeida Corrêa Paulo Sérgio , Lima da Silva Elaniese Do Socorro 
Published: January 2024

Construímos este estudo com a finalidade de apresentar e analisar a aplicação de extensão de navegador de internet sobre a plataforma Currículo Lattes para demonstrar informações detalhadas da pontuação de artigos publicados em periódicos. A disponibilidade de mais informações sobre a pontuação de publicações qualificadas dos pesquisadores na Plataforma do Currículo Lattes do CNPq pode auxiliar as instituições de ensino superior a construírem planos de trabalho dos seus servidores que levam em consideração a produção acadêmica? Procedemos metodologicamente utilizando a pesquisa bibliográfica, documental e a demonstração da utilização das extensões QLattes e Qualis no Lattes, considerando o período histórico de 2018 a 2023. As conclusões evidenciaram ser possível, a partir de disponibilização de dados quantificados, uma instituição acompanhar a produção de seu quadro docente e, ao mesmo tempo, ter condições de construir planos de trabalho considerando as atividades acadêmicas de seus profissionais.
Psychological Perspectives on Social Relations and Social Competence in Childhood
Authors: Nechifor Constantin , Sandovici Anișoara 
Published: January 2024

The present paper focuses on a sensitive and challenging psychological problem, namely, the problem of children’s socialization during the first years of life.How young children’s social skills are produced,developed and structured,significantly influences the course of future personal development.Certainly,the time period in which generations are born and developed,significantly influences human psychology in action.A comparative perspective on generations provides a deeper understading of the dynamics of personal life,which spill over into the dynamics of social life.Beyond the data provided by researchers the challenges of present life sensitize us to the importance of being developing and manifesting our social skills at every stage of ontogenetic development.
Intervenciones al cuidador familiar del niño con discapacidad intelectual: Revisión integrativa
Authors: García-Morán Gretel Alexandra , Castillo-Arcos Lubia del Carmen , García-Campos María de Lourdes , Patiño-López María Esther 
Published: January 2024

Objetivo: Describir las intervenciones realizadas al cuidador familiar del niño con discapacidad intelectual.
Materiales y métodos: Revisión integradora en las bases de datos PubMed, LILACS, BVS y Scielo, considerando los criterios de inclusión: antigüedad ≤ 10 años, en idioma inglés, español y portugués, que la intervención estuviera dirigida al cuidador familiar (madres o padres). Se utilizaron los descriptores intervention, caregiver, intelectual disability, child y el operador booleano AND. Se identificaron 233 artículos, 210 fueron discriminados porque las intervenciones estuvieron dirigidas a los niños, quedando 23 artículos y de estos se eliminaron 17 por no cumplir su totalidad los criterios de inclusión, solo quedó una muestra de 6.
Resultados: Las intervenciones identificadas fueron psicosocial, psicoeducativa, musicoterapia y terapia ocupacional, logrando disminuir síntomas como depresión, ansiedad, tristeza y estrés, así como niveles de sobrecarga e indiferencia.
Conclusiones: Las intervenciones impactan positivamente en la salud del cuidador familiar del niño con discapacidad intelectual. El profesional de enfermería debe encaminarse en el diseño e implementación de intervenciones dirigidas al cuidador familia para su cuidado integral.
Palabras clave: Intervención; Cuidadores; Niños; Discapacidad intelectual.
Exposición al Dicloro Difenil Tricloroetano y perfil tiroideo durante el embarazo: revisión sistemática y meta-análisis
Authors: Hernández-Mariano José Ángel , Castañeda-Márquez Ana Cristina , Fragoso Lucero Analy , Orbe-Orihuela Yaneth Citlalli 
Published: January 2024

Objetivo: Evaluar la asociación entre la exposición al p,p´-DDT y p,p´-DDE con la disrupción tiroidea durante el embarazo a través de un metaanálisis.
Material y métodos: Se realizó una revisión sistemática y un meta-análisis basado en la declaración PRISMA (Preferred Reporting Items for Systematic Reviews and Meta-Analysis). El protocolo de esta revisión se registró ante el International Prospective Register of Systematic Reviews (PROSPERO) con el folio de identificación: CRD42022324797. Se llevó a cabo una búsqueda en las bases de datos electrónicas PubMed y Web of Science para identificar los estudios elegibles publicados en inglés y español hasta el 2 de enero de 2022. Mediante meta-análisis de efectos aleatorios, se estimó un coeficiente de regresión beta (β) combinado, por cada hormona del perfil tiroideo, a partir de los β publicados de cada estudio y sus intervalos de confianza del 95% (IC del 95%).
Resultados: Se incluyeron ocho estudios de los cuales solamente tres reportaron biomarcadores de exposición a p,p'-DDT, por lo que no fue posible conducir meta-análisis para evaluar la relación entre este compuesto y las hormonas del perfil tiroideo. La exposición a p,p'-DDE se asoció con un ligero incremento en los niveles de TSH (β combinada= 0.05; IC95%= -0.01. 0.12) y T3 total (β combinada= 0.02; IC95%= -0.05, 0.09), pero inversamente con los niveles de la T4 total (β combinada= -0.003; IC 95%= -0.05, 0.05) y T4 libre (β combinada= -0.01; IC95%= -0.03, 0.01), aunque ninguno de estos hallazgos fue estadísticamente significativo.
Conclusiones: La evidencia disponible a la fecha aún es limitada como para emitir una conclusión sobre la asociación entre las variables de interés. Dado que pequeños cambios en la homeóstasis tiroidea de mujeres embarazadas podrían tener consecuencias en el desarrollo fetal, es necesario seguir generando evidencia al respecto.
Palabras claves: Dicloro-difenil-tricloroetano; dicloro-difenil-dicloroetileno; hormonas tiroideas; Embarazo.
Factores asociados al nivel de autoeficacia en mujeres lactantes del IMSS, Tabasco
Authors: Garrido Pérez Silvia María Guadalupe , Xala Méndez César Alberto , Domínguez Vega Guadalupe Montserrat 
Published: January 2024

Objetivo: Determinar los factores asociados al nivel de autoeficacia en las mujeres lactantes de la UMF No. 47, IMSS, Tabasco.
Material y Métodos: Estudio observacional, transversal y analítico, en una muestra de 197 mujeres lactantes, que cumplieron los criterios de inclusión. Se aplicó un cuestionario sociodemográfico y obstétrico diseñado por el investigador, y la escala de autoeficacia de lactancia materna en su forma corta (BSES-SF), de 14 ítems, con alfa de Cronbach de 0.92. El análisis incluyo estadística descriptiva, así como estadística inferencial donde se utilizó la prueba chi cuadrada de Pearson. Se obtuvo la magnitud de asociación, con los riesgos de prevalencia (tablas de 2x2), y valor de p≤0.05 con prueba exacta de Fisher. Los datos fueron procesados en el programa estadístico SPSS 25 y STATA 6.
Resultados: Edad mínima 17 y máxima 40, predominó el grupo de 21-25 años con 31.5% (X2=109.944a, gl=8, p<.001, RP 7.87, prueba exacta de Fisher p<0.001), unión libre con 46.2% (X2=71.736a, gl=6, p<.001, RP 6.51, prueba exacta de Fisher p<0.001), preparatoria con 41.1% (X2=18.252a, gl=6, p<.006, RP 1.51, prueba exacta de Fisher p<0.04), nivel socioeconómico medio con 52.8% (X2=38.784a, gl=4, p<.001, RP 3.42, prueba exacta de Fisher p<0.001), con 2 hijos el 35% (X2=44.647a, gl=6, p<.001, RP 4.65, prueba exacta de Fisher p<0.001) y si recibió orientación con 94.9% (X2=5.175a, gl=2, p=.075, RP .910, prueba exacta de Fisher p<0.03).
Conclusiones: Los factores como la edad, estado civil, escolaridad, nivel socioeconómico, paridad y la orientación recibida, se asociaron al nivel de autoeficacia de lactancia materna, mientras que la ocupación y tipo de parto no se asociaron.

Palabras Claves: Lactancia materna; Autoeficacia; Factores.