bluuebunny/crossref_metadata_2025_split huggingface dataset:
TAZ acting as a potential pathogenic biomarker to promote the development of lichen planus
Authors: Wang Ning , Bai Ruimin , Cheng Baochen , Luo Ruiting , He Ke , Du Wenqian , Yin Tingyi , Liang Qiongwen , Zheng Yan 
Published: January 2024

AbstractBackgroundLichen planus is a chronic inflammatory disorder. Transcriptional coactivator with PDZ‐binding motif (TAZ/WWTR1) is an important downstream effector of the Hippo pathway which regulates organ size and tissue homeostasis. But little is known about the role of TAZ in lichen planus so far.ObjectiveTo explore the expression of TAZ in lichen planus and normal skin, and to discover the relationship between TAZ expression and the clinical characteristics of lichen planus patients.MethodsThe method of immunohistochemistry was performed to quantify the expression of TAZ in 262 patients with lichen planus and 90 control tissues. Western blot and quantitative real‐time reverse transcriptase‐PCR (qRT‐PCR) analysis were performed to examine and compare TAZ expression in 4 cases of fresh lichen planus lesions and normal skin tissues.ResultsTAZ was weakly expressed in the basal layers of the epidermis in normal skin tissues with a positive rate of 52.22% (47/90). But in lichen planus, TAZ was strongly expressed in almost the entire epidermis with a positive rate of 81.30% (213/262), and the difference between the two groups was statistically significant (p<0.05). Additionally, TAZ expression was significantly related to the location of the lichen planus, clinical phenotype, smoking, and alcohol preference (p<0.05). Western blot and qRT‐PCR showed that the expression of TAZ in protein and mRNA levels in four cases of lichen planus lesions was significantly higher than that in normal skin tissues.ConclusionTAZ may play a regulatory role in the occurrence and development of lichen planus, which might provide a new perspective for studying pathogenesis and theoretical treatment targets.
Deploying whole blood to the battlefield—The Israel Defense Forces Medical Corps initial experience during the 2023 war
Authors: Almog Ofer , Benov Avi , Beer Zivan , Sirotkin Tsvi , Shental Omri , Glassberg Elon 
Published: January 2024

AbstractBackgroundMilitary and prehospital medical organizations invest significant resources to advance the treatment of trauma patients aiming to reduce preventable deaths. Focus is on hemorrhage control and volume resuscitation with blood products, with adoption of Remote Damage Control Resuscitation (RDCR) guidelines. The Israel Defense Forces Medical Corps (IDF‐MC) has been using tranexamic acid and freeze‐dried plasma (FDP) as part of its RDCR protocol for more than a decade. In recent years, low‐titer group O whole blood (LTOWB) has been integrated, on IDF evacuation helicopters and expanded to mobile ambulances, complementing FDP use in treating trauma patients in state of profound shock.Study Design and MethodsDuring the war that erupted in October 2023, the IDF‐MC made a decision to bring LTOWB forward, and to equip every combat brigade level mobile intensive care units with LTOWB, onboard armored vehicles. The goal was to make whole blood available as close as possible to the point of injury and within minutes from time of injury.Results and DiscussionWe describe the IDF‐MCs' efforts to bring LTOWB to the front lines and present four cases in which LTOWB was administered. All patients were young male, with significant blood loss following penetrating injuries. One patient died in the operating room, following hospital arrival and emergency thoracotomy. The others survived. Our initial experience with bringing LTOWB as close as possible to the point of injury during high intensity fighting is encouraging, showing patient benefit along with logistic feasibility. After action reports and data collection will continue.
Prevalence of middle ear effusion in French bulldogs without clinical signs of otic disease: A retrospective study of magnetic resonance imaging (2017–2022)
Authors: Urkiola Ane , Domínguez Elisabet , Solà‐Montrabeta Mar , Bardagí Mar 
Published: January 2024

AbstractBackgroundCanine middle ear effusion (MEE) is usually asymptomatic, being an incidental finding when computed tomography or magnetic resonance imaging (MRI) of the head is performed for other reasons unrelated to otic disease. The clinical relevance of the presence of material in the tympanic bulla (TB) remains uncertain, and more detail about its prevalence and appearance in MRI are required.ObjectiveTo assess the prevalence of presence of material within the TB of French bulldogs (FB) with no clinical signs suggestive of otitis (externa, media or interna) that underwent high‐field MRI for other medical reasons.AnimalsTwo hundred fifty‐two TB of 126 FB were included in this study.Materials and MethodsNonexperimental retrospective study in which MRI images were evaluated by a board‐certified veterinary radiologist.ResultsFifty‐eight per cent of the dogs had material in the TB lumen (46% of the TB) and 59% were bilaterally affected. The signal intensity of this material related to the grey matter was variable on T1w and mainly hyperintense on T2w sequences.Conclusion and Clinical RelevanceFB are predisposed to MEE. This is important when assessing imaging studies of TB of FB with chronic otitis externa, as high percentage of cases may have concurrent MEE. MRI findings in FB with MEE are characterised by a hyperintense signal to the grey matter on T2w in most cases and variable on T1w sequences.
Injury incidence according to athlete impairment type during the 2012 and 2016 Summer Paralympic Games: a combined analysis of 101 108 athlete days
Authors: Adam Faatima , Derman Wayne , Schwellnus Martin , Boer Pieter-Henk , Jordaan Esme , Runciman Phoebe 
Published: January 2024

ObjectivesThe relationship between sport-related injuries and Para athlete impairment type has not yet been comprehensively studied. This study aimed to describe injury incidence according to athlete impairment type during the London 2012 and Rio 2016 Summer Paralympic Games, by sex, age, Games period, chronicity and anatomical area.MethodsA combined analysis of 7222 athletes was conducted comprising 101 108 athlete days, using pooled data. Internet sources were used to identify impairments of registered athletes. Impairment types: brain disorders (BD), limb deficiency, neuromuscular disorders (NMD), spinal cord-related disorders, visual impairment (VI) and ‘all others’ (OTH: impaired passive range of movement, intellectual impairment, leg length difference, short stature and unknown impairments). Results by impairment type are reported as univariate unadjusted incidences (injuries/1000 athlete days; 95% CIs). Statistical significance between impairment types was determined when 95% CIs did not overlap.ResultsThe overall crude unadjusted incidence of injury was 11.1 (95% CI 10.4 to 11.9), significantly higher in VI (13.7 (95% CI 11.0 to 15.7)) and NMD (13.3 (95% CI 11.1 to 16.1)) compared with BD (9.1 (95% CI 7.7 to 10.8)). Acute (sudden onset) (8.6 (95% CI 7.3 to 10.1)) and lower limb (6.6 (95% CI 5.4 to 8.1)) injuries were higher among athletes with VI, while athletes with NMD had a higher incidence of repetitive (gradual onset) (5.9 (95% CI 4.3 to 8.0)) and upper limb (6.9 (95% CI 5.2 to 9.0)) injuries compared with other impairments.ConclusionsIncidence and type of injuries differed between athlete impairment types. Athletes with VI or NMD sustained the highest incidence of injury, and athletes with BD had the lowest. Findings of this study can inform the management of competition-related injuries in Para athletes.
Effect of ischaemic postconditioning on markers of myocardial injury in ST-elevation myocardial infarction: a meta-analysis
Authors: Bergman Idan , Gelikas Shaul , Wexler Yehuda , Braver Omri , Boyle Dennis , Nussinovitch Udi 
Published: January 2024

ObjectivesThis study aimed to perform a meta-analysis of the short-term impact of ischaemic postconditioning (IPoC) on myocardial injury in ST elevation myocardial infarction (STEMI) using surrogate cardiac biomarkers.MethodsEligible studies were identified using several article databases. Randomised controlled trials published between 1 January 2000 and 1 December 2021 comparing IPoC to standard of therapy in STEMI patients were included in the search. Outcomes included surrogates of myocardial injury, specifically peak troponin, creatine-kinase (CK) and CK myoglobin binding (CK-MB) enzyme levels.Results11 articles involving 1273 patients reported on CK-MB and 8 studies involving 505 patients reported on CK. Few studies used troponin as an outcome, thus, a subanalysis of troponin dynamics was not performed. Meta-regression analysis demonstrated no significant effect of IPoC on peak CK-MB (effect size −0.41, 95% CI −1.15 to 0.34) or peak CK (effect size −0.42, 95% CI −1.20 to 0.36). Linear regression analysis demonstrated a significant correlation between a history of smoking and CK-MB in the IPoC group (p=0.038).ConclusionsIPoC does not seem to protect against myocardial injury in STEMI, except possibly in smokers. These results resonate with some studies using imaging techniques to ascertain myocardial damage. More research using troponin and cardiac imaging should be pursued to better assess the effects of IPoC on cardiovascular outcomes in STEMI.
Complications after pediatric percutaneous endoscopic gastrostomy: comparison of the push and pull technique
Authors: Takalo Mona , Iber Tarja , Autio Reija , Luoto Topi 
Published: January 2024

PurposeVarious complications are associated with percutaneous endoscopic gastrostomy (PEG) procedures in children. The push technique is being increasingly used, but its complications are insufficiently characterized. We aimed to assess all complications related to PEG procedures and compare the safety of the pull and push techniques.MethodsRetrospective review of consecutive pediatric patients who underwent PEG between 2002 and 2020.ResultsIn total, 216 children underwent 217 PEG procedures. The push technique was used in 138 (64%) cases, and the pull technique in 79 (36%) cases. The median follow-up time was 6.1 (0.1–18.3) years. The complication rate was high (57%) and patients experienced complications years after the procedure. Overall, 51% and 67% of patients experienced complications in the push and pull groups, respectively. The rates of minor and major complications were higher in the pull group than in the push group (63% vs 48%,p=0.028; and 11% vs 6%,p=0.140, respectively). Reoperation was also more common in the pull group (17% vs 7%,p=0.020).ConclusionsThe overall complication rate of PEG procedures is high. Fortunately, most complications are mild and do not require reoperations. The increasing push technique appears to be safer than the traditional pull technique. Significant long-term morbidity is related to gastrostomies in children.
Holographic Schwinger effect in anisotropic media
Authors: Zhou Jing , Chen Jun , Zhang Le , Ping Jialun , Chen Xun 
Published: January 2024

AbstractAccording to gauge/gravity correspondence, we study the holographic Schwinger effect within an anisotropic background. Firstly, the separate length of the particle–antiparticle pairs is computed within the context of an anisotropic background which is parameterized by dynamical exponent $$\nu $$
ν
. It is found that the maximum separate length x increases with the increase of dynamical exponent $$\nu $$
ν
. By analyzing the potential energy, we find that the potential barrier increases with the dynamical exponent $$\nu $$
ν
at a small separate distance. This observation implies that the Schwinger effect within an anisotropic background is comparatively weaker when contrasted with its manifestation in an isotropic background. Finally, we also find that the Schwinger effect in the transverse direction is weakened compared to the parallel direction in the anisotropic background, which is consistent with the top-down model.
Topology of Hořava–Lifshitz black holes in different ensembles
Authors: Chen Deyou , He Yucheng , Tao Jun , Yang Wei 
Published: January 2024

AbstractIn this paper, we study topological numbers for uncharged and charged static black holes obtained in $$z=3$$

z
=
3

Hořava–Lifshitz gravity theory in different ensembles, where z measures the degree of anisotropy between space and time. We first calculate the topological numbers for the uncharged black holes by changing the value of the dynamic coupling constant, and find that the black holes with spherical and flat horizons have the same topological number. When the black hole’s horizon is hyperbolic, different values of the coupling constant generate different topological numbers, which can be 1, 0 or $$-1$$

-
1

. This shows that the coupling constant plays an important role in the topological classification. Then we study the topological numbers for the charged black holes in different ensembles. The black hole with a spherical horizon has the same topological number in canonical and grand canonical ensembles. When the horizons are flat or hyperbolic, they have different topological numbers in canonical and grand canonical ensembles. Therefore, the topological numbers for the uncharged black holes are parameter dependent, and those for the charged black holes are ensemble dependent.
Constraining the growth rate on linear scales by combining SKAO and DESI surveys
Authors: Dlamini Simthembile , Jolicoeur Sheean , Maartens Roy 
Published: January 2024

AbstractIn the pursuit of understanding the large-scale structure of the Universe, the synergy between complementary cosmological surveys has proven to be a powerful tool. Using multiple tracers of the large-scale structure can significantly improve the constraints on cosmological parameters. We explore the potential of combining the Square Kilometre Array Observatory (SKAO) and the Dark Energy Spectroscopic Instrument (DESI) spectroscopic surveys to enhance precision on the growth rate of cosmic structures. We employ a multi-tracer Fisher analysis to estimate precision on the growth rate when using pairs of mock surveys that are based on SKAO and DESI specifications. The pairs are at both low and high redshifts. For SKA-MID, we use the HI galaxy and the HI intensity mapping samples. In order to avoid the complexities and uncertainties at small scales, we confine the analysis to scales where linear perturbations are reliable. The consequent loss of signal in each individual survey is mitigated by the gains from the multi-tracer. After marginalising over cosmological and nuisance parameters, we find a significant improvement in the precision on the growth rate.
Which sport is becoming more predictable? A cross-discipline analysis of predictability in team sports
Authors: Coscia Michele 
Published: January 2024

AbstractProfessional sports are a cultural activity beloved by many, and a global hundred-billion-dollar industry. In this paper, we investigate the trends of match outcome predictability, assuming that the public is more interested in an event if there is some uncertainty about who will win. We reproduce previous methodology focused on soccer and we expand it by analyzing more than 300,000 matches in the 1996-2023 period from nine disciplines, to identify which disciplines are getting more/less predictable over time. We investigate the home advantage effect, since it can affect outcome predictability and it has been impacted by the COVID-19 pandemic. Going beyond previous work, we estimate which sport management model – between the egalitarian one popular in North America and the rich-get-richer used in Europe – leads to more uncertain outcomes. Our results show that there is no generalized trend in predictability across sport disciplines, that home advantage has been decreasing independently from the pandemic, and that sports managed with the egalitarian North American approach tend to be less predictable. We base our result on a predictive model that ranks team by analyzing the directed network of who-beats-whom, where the most central teams in the network are expected to be the best performing ones. Our results are robust to the measure we use for the prediction.
HDAC Inhibition Induces CD26 Expression on Multiple Myeloma Cells via the c-Myc/Sp1-mediated Promoter Activation
Authors: Nishida Hiroko , Suzuki Reiko , Nakajima Kiyora , Hayashi Mutsumi , Morimoto Chikao , Yamada Taketo 
Published: January 2024

Abstract

CD26 is ubiquitously and intensely expressed in osteoclasts in patients with multiple myeloma, whereas its expression in plasma cells of patients with multiple myeloma is heterogeneous because of its cellular diversity, immune escape, and disease progression. Decreased expression levels of CD26 in myeloma cells constitute one of the mechanisms underlying resistance to humanized anti-CD26 mAb therapy in multiple myeloma. In the current study, we show that histone deacetylase inhibition (HDACi) with broad or class-specific inhibitors involves the induction of CD26 expression on CD26neg myeloma cells both transcriptionally and translationally. Furthermore, dipeptidyl peptidase Ⅳ (DPPⅣ) enzymatic activity was concomitantly enhanced in myeloma cells. Combined treatment with HDACi plus CD26mAb synergistically facilitated lysis of CD26neg myeloma cells not only by antibody-dependent cellular cytotoxicity but also by the direct effects of mAb. Of note, its combination readily augmented lysis of CD26neg cell populations, refractory to CD26mAb or HDACi alone. Chromatin immunoprecipitation assay revealed that HDACi increased acetylation of histone 3 lysine 27 at the CD26 promoter of myeloma cells. Moreover, in the absence of HDACi, c-Myc was attached to the CD26 promoter via Sp1 on the proximal G-C box of myeloma cells, whereas, in the presence of HDACi, c-Myc was detached from Sp1 with increased acetylation of c-Myc on the promoter, leading to activation of the CD26 promoter and initiation of transcription in myeloma cells. Collectively, these results confirm that HDACi plays crucial roles not only through its anti-myeloma activity but by sensitizing CD26neg myeloma cells to CD26mAb via c-Myc/Sp1-mediated CD26 induction, thereby augmenting its cytotoxicity.

Significance:
There is a desire to induce and sustain CD26 expression on multiple myeloma cells to elicit superior anti-myeloma response by humanized anti-CD26 mAb therapy. HDACi upregulates the expression levels of CD26 on myeloma cells via the increased acetylation of c-MycK323 on the CD26 promoter, leading to initiation of CD26 transcription, thereby synergistically augments the efficacy of CD26mAb against CD26neg myeloma cells.
Effects of packetization on communication dynamics in brain networks
Authors: Fukushima Makoto , Leibnitz Kenji 
Published: January 2024

Abstract
Computational studies in network neuroscience build models of communication dynamics in the connectome that help us understand the structure-function relationships of the brain. In these models, the dynamics of cortical signal transmission in brain networks are approximated with simple propagation strategies such as random walks and shortest path routing. Furthermore, the signal transmission dynamics in brain networks can be associated with the switching architectures of engineered communication systems (e.g., message switching and packet switching). However, it has been unclear how propagation strategies and switching architectures are related in models of brain network communication. Here, we investigate the effects of the difference between packet switching and message switching (i.e., whether signals are packetized or not) on the transmission completion time of propagation strategies when simulating signal propagation in mammalian brain networks. The results show that packetization in the connectome with hubs increases the time of the random walk strategy and does not change that of the shortest path strategy, but decreases that of more plausible strategies for brain networks that balance between communication speed and information requirements. This finding suggests an advantage of packet-switched communication in the connectome and provides new insights into modeling the communication dynamics in brain networks.
Одоризмы как отражение оценочного восприятия в романе Л. Улицкой "Казус Кукоцкого"
Authors: Шимула [Szymula] Роберт [Robert] , Анхимюк [Anchimiuk] Ольга [Olga] 
Published: January 2024

Olfactory Vocabulary as a Reﬂection of Evaluative Perception in Ludmila Ulitskaya’s Novel The Kukotsky Enigma
The aim of this article is to analyse the olfactory vocabulary in the novel Kazus Kukotskogo by Ludmila Ulitskaya (2001; English edition: The Kukotsky Enigma, 2016). The issues addressed in the novel are topical and controversial. The theme of the degeneration of Soviet man is revealed against the background of his contacts with the odours of the natural world and the world of civilisation. The study applies a general classification of olfactory vocabulary developed on the basis of the research by M. Schleidt, P. Newman and H. Morishita, as well as N. S. Pavlova.
Explications of smells in the novel include nouns (zapakh, dukh, aromat, dushok), adjectives (pakhuchiĭ, voniuchiĭ, smradnyĭ, smerdiashchiĭ) and verbs (denoting the manifestation of smell: pakhnutʹ, nesti, voniatʹ; denoting the perception of smell: vdykhatʹ, vtianutʹ/vtiagivatʹ, priniukhivatʹsia, chuiatʹ). The evaluative component gradually intensifies as one moves away from nature and approaches the social aspect of human life. The correlation between the concepts of fragrance (good) and stench (evil, sin) is associated with the characteristics of nature and civilisation. The lexemes used to nominate and characterise negatively labelled odours belong to a civilisation that is far from nature and contrary to its values.
Słownictwo dotyczące zapachów jako odzwierciedlenie percepcji wartościującej w powieści Ludmiły Ulickiej Przypadek doktora Kukockiego
Artykuł podejmuje analizę słownictwa dotyczącego zapachów w powieści Казус Кукоцкого Ludmiły Ulickiej (2001; wydanie polskie: Przypadek doktora Kukockiego, 2006). Zagadnienia poruszane w powieści są aktualne i kontrowersyjne. Temat degeneracji człowieka radzieckiego ujawnia się na tle jego kontaktów z zapachami świata natury i świata cywilizacji. W artykule zastosowano ogólną klasyfikację słownictwa dotyczącego zapachów opracowaną na podstawie badań M. Schleidta, P. Newmana i H. Morishity oraz N. S. Pawłowej.
Eksplikacje zapachów w omawianej powieści obejmują rzeczowniki (запах, дух, аромат, душок), przymiotniki (пахучий, вонючий, смрадный, смердящий) i czasowniki (oznaczające przejawianie się zapachu: пахнуть, нести, вонять; oznaczające percepcję zapachu: вдыхать, втянуть/втягивать, принюхиваться, чуять). Komponent wartościujący stopniowo nasila się w miarę oddalania się od natury i zbliżania do społecznego aspektu życia człowieka. Korelacja między pojęciami woni (dobro) i odoru (zło, grzech) jest powiązana z cechami natury i cywilizacji. Leksemy używane do nominacji i charakterystyki negatywnie oznaczanych zapachów należą do cywilizacji oddalonej od natury i sprzecznej z jej wartościami.