bluuebunny/crossref_metadata_2025_split huggingface dataset:
TAVI: Ist das Verfahren eine Alternative bei Patienten ohne erhöhtes Operationsrisiko?
Authors: Strohleit Daniel , Seiffert Moritz 
Published: February 2025

ZusammenfassungDie kathetergestützte Aortenklappenimplantation (TAVI) hat sich als sichere und effektive Prozedur zur Behandlung der hochgradigen symptomatischen Aortenklappenstenose etabliert und wird mittlerweile auch bei Patienten niedrigen und intermediären Risikos eingesetzt. Die verfügbaren Studien hierzu umfassen mittlerweile mehr als 9000 Patienten mit sehr vielversprechenden Ergebnissen für das kathetergestützte Verfahren im Vergleich mit dem operativen Aortenklappenersatz. Inwieweit sich diese Ergebnisse auch über einen langfristigen Nachbeobachtungszeitraum bestätigen, bleibt derzeit noch abzuwarten. Auch darüber hinaus wird das interdisziplinäre Herzteam integraler Bestandteil der Indikationsstellung und Therapieplanung bleiben.
Transkathetergestützter Mitralklappenersatz (TMVR): Chancen, Herausforderungen und innovative Entwicklungen
Authors: Mehrkens Dennis , Adam Matti 
Published: February 2025

ZusammenfassungDie Therapie der Mitralklappeninsuffizienz (MI) mittels transvenöser
Mitralklappenprothesen (TMVR) bietet eine vielversprechende minimalinvasive Option für
Hochrisikopatienten, die keine Operation erhalten können. Die komplexe Anatomie der
Mitralklappe und ihre Nähe zum linksventrikulären Ausflusstrakt (LVOT) stellen jedoch
technische Herausforderungen dar. Verkalkungen des Mitralklappenanulus erschweren zudem
die Behandlung. TMVR-Systeme zeigen vielversprechende Ergebnisse, wobei innovative
Verankerungsmechanismen die Risiken, wie die LVOT-Obstruktion, minimieren. Dennoch
bleibt die Patientenauswahl problematisch, da viele Patienten aufgrund anatomischer
Einschränkungen für TMVR ungeeignet sind. Zukünftige Entwicklungen in der
Prothesentechnologie und Zugangsverfahren könnten diese minimalinvasive Therapieoption
weiter verbessern. Langfristige Daten und technologische Fortschritte sind notwendig, um
TMVR als Standardbehandlung zu etablieren und die Therapie von MI zu
revolutionieren.
Trikuspidalklappeninsuffizienz – Optimierung der Ergebnisse durch individualisierte Therapie
Authors: Stocker Thomas J. , Stolz Lukas , Hausleiter Jörg 
Published: February 2025

ZusammenfassungDie hochgradige Trikuspidalklappeninsuffizienz ist eine schwerwiegende Erkrankung und mit einer ungünstigen Prognose vergesellschaftet. Mit der Entwicklung neuer interventioneller Therapieoptionen nimmt die Erkrankung innerhalb der Kardiologie einen zunehmenden Stellenwert ein. Das heterogene Erscheinungsbild und das Auftreten im Kontext unterschiedlicher Begleiterkrankungen bedürfen einer detaillierten diagnostischen Aufarbeitung. Dabei sollte die Erkrankung in einem möglichst frühen Stadium der Rechtsherzinsuffizienz identifiziert und weiterführend abgeklärt werden, um durch eine rechtzeitige Therapie mögliche Endorganschäden zu verhindern. Nach interdisziplinärer Falldiskussion und Abwägung aller medikamentösen, chirurgischen und interventionellen Optionen findet die individualisierte Therapie und anschließende strukturierte Nachverfolgung der Patienten im Herzklappenzentrum statt. Nachdem der Behandlungserfolg von der Erfahrung des Herzklappenzentrums abhängig ist, sollten interventionellen Eingriffe vorrangig in hochvolumigen Zentren mit hoher Expertise durchgeführt werden. Nur so kann der nach wie vor hohen Morbidität und Letalität der Rechtsherzinsuffizienz und Trikuspidalklappeninsuffizienz begegnet werden.
Evaluation of the Impact of Implementing Electronic Prescription in an Oncology Referral Hospital in Recife, Brazil
Authors: Falcão Diana Carla Gouveia , Soares Ana Lara Vieira , Araujo-Junior Hermes Castro de , Souza-Filho José Kilderlan Nascimento de , Medeiros Natália Moura Farias de , Mota Paulo Victor Brasileiro , Madeira-Neto Rodolfo Basílio , Maia Tiago Costa , Pereira Marcio Roberto Pinho , Medeiros Maria Angelina Silva 
Published: February 2025

Abstract
Introduction The occurrence of errors in the prescription of antineoplastic oncological drugs constitutes a serious public health problem, directly affecting patient safety. In Brazil, the Protocol for the Safety in Prescription, Use, and Administration of Medications, established in 2013, aims to improve care related to medication use in healthcare facilities. This study aims to evaluate the prescription profiles of patients undergoing antineoplastic chemotherapy treatment admitted to the Pernambuco Cancer Hospital before and after the implementation of electronic prescription.
Materials and Methods The present cross-sectional study was conducted by analyzing manual and electronic prescriptions collected from the clinical oncology ward of the Pernambuco Cancer Hospital during the periods from March to May 2016 and from June to August 2016, respectively. The data collected were extracted into a specific instrument, previously adapted for the study, containing information related to patients, prescribers, and medications. Descriptive statistics were used for data analysis.
Results Among the 694 prescriptions analyzed, prescription errors were found in at least one item, with the omission of the patients' sex and bed number being the most common findings.
Conclusion All of the prescriptions analyzed, both pre- and postcomputer standardization, contained errors in their completion. With the standardized prescriptions, a significant impact was observed in reducing these rates, especially regarding omission of items and information.
1.7 Synthesis of Difluoromethylene-Containing Compounds
Authors: Luo Y.-C. , Zhang X. 
Published: February 2025

AbstractThe difluoromethylene group (CF2) is a valuable fluorinated motif that is widely present in pharmaceuticals, agrochemicals, and advanced functional materials because of the unique properties of fluorine atoms. Consequently, considerable efforts have been dedicated to introducing the difluoromethylene group into organic molecules. This review summarizes progress in the synthesis of difunctionalized difluoromethane (R1−CF2−FG) compounds, including methods for the difluoroalkylation of C—X and unsaturated bonds, and gem-difluorination reactions.
1.10 The Pentafluorosulfanyl Group (SF5)
Authors: Kordnezhadian R. , De Borggraeve W. M. , Ismalaj E. 
Published: February 2025

AbstractThe pentafluorosulfanyl group imparts exceptional thermal, chemical, and metabolic stability to organic scaffolds. Despite being first described seven decades ago, it remains an under-utilized motif in organofluorine chemistry, primarily due to a lack of efficient synthetic routes that proceed under mild reaction conditions. Nonetheless, the renewed interest in pentafluorosulfanyl scaffolds over the last decade has enabled the preparation of important pentafluorosulfanyl building blocks. Herein, the major synthetic strategies for the preparation of pentafluoro-λ6-sulfanyl-containing compounds are reviewed, including the synthesis of (pentafluorosulfanyl)arenes via oxidative halogenation and the direct pentafluorosulfanylation of aliphatic cores, achieved mainly using pentafluorosulfanyl chloride as a reagent.
1.8 Synthesis of (Trifluoromethyl)sulfanyl (SCF3) Compounds
Authors: Xu C. , Shao X. , Shen Q. 
Published: February 2025

Abstract(Trifluoromethyl)sulfanyl compounds have garnered significant attention in medicinal chemistry, agrochemistry, and materials science due to their unique physicochemical properties, including high lipophilicity, metabolic stability, and strong electron-withdrawing ability. This review pro-vides a comprehensive overview of the current methods for the synthesis of (trifluoromethyl)sulfanyl compounds, highlighting recent advances and emerging strategies. Key synthetic approaches, such as direct (trifluoromethyl)sulfanylation, transition-metal-catalyzed processes, and radical-based methods are discussed with an emphasis on the substrates and reagents. The chapter also briefly introduces the mechanistic insights and the role of novel reagents in enhancing the efficiency and selectivity of these synthetic transformations.
Convergent, discriminant, and known-groups validity of the Behavioural Assessment Screening Tool (BAST) in chronic traumatic brain injury
Authors: Juengst Shannon , Wright Brittany , Vos Leia , Rodriguez Gabriel , Conley Michael , Terhorst Lauren 
Published: February 2025

Background The Behavioural Assessment Screening Tool (BAST), which measures self-reported neurobehavioural symptoms experienced by adults with traumatic brain injury (TBI), was specifically developed as a self-reported measure for remote symptom reporting. Our aim was to assess the convergent, discriminant, and known-groups validity of the BAST among community-dwelling adults with TBI. Methods We assessed correlations and group differences with previously validated measures in two existing datasets (n = 111, n = 134). Other measures were the Patient Health Questionnaire-9 (depression), Generalized Anxiety Disorder-7 (anxiety), Positive and Negative Affect Schedule, Frontal Systems Behavior Scale (Executive Dysfunction, Apathy, Disinhibition), Modified Fatigue Impact Scale, Patient-Reported Outcomes Measurement Information System (Fatigue), Aggression Questionnaire (anger, hostility, physical and verbal aggression), and Alcohol Use Disorders Identification Test (alcohol misuse). Results BAST subscales had stronger correlations with measures of similar (|r| = 0.602–0.828, P < 0.001) and related (|r| = 0.364–0.589, P < 0.001) constructs and weaker correlations (|r| < 0.300) with measures of dissimilar/unrelated constructs. Statistically significant BAST subscale differences (ps < 0.001) were found (Cohen’s d = 1.2–1.9) for known groups with moderate–severe depression, moderate-severe anxiety, fatigue, problematic disinhibited and frontal executive behaviours, and alcohol misuse. Results support the construct validity of the BAST subscales. Conclusion(s) The BAST demonstrated good convergent, discriminant, and known-groups validity, supporting its use for remote self-reported symptom reporting to improve chronic symptom monitoring in community-dwelling adults with TBI.
Perfect confinement of acoustic vortex by phase-gradient metacage
Authors: Fang Xicheng , Li Songsong , Sun Baoyin , Yan Dongyang , Yang Junyi , Luo Jie , Gao Dongliang , Xu Yadong 
Published: February 2025

Abstract
Acoustic wave isolation and noise reduction represent significant challenges in the field of physics and its various applications. Traditional noise control devices are often hampered by substantial size limitations and their operational efficacy is generally restricted to planar waveforms. In this work, we demonstrate the perfect confinement of acoustic vortex waves using an acoustic metacage consisting of phase-gradient metasurfaces. By leveraging the parity-reversed diffraction rule of the phase-gradient metasurfaces, the designed metacage exhibits remarkable capabilities for perfect confinement of acoustic vortex waves, showcasing robust performance even with source offsets. These findings present a promising strategy for the development of precise and adaptable acoustic confinement technologies.
Prediction of dual quantum spin Hall insulator in NbIrTe4 monolayer
Authors: Liu Xiangyang , Lai Junwen , Zhan Jie , Yu Tianye , Shi Wujun , Liu Peitao , Chen Xing-Qiu , Sun Yan 
Published: February 2025

Abstract
Dual quantum spin Hall insulator (QSHI) is a newly discovered topological state in the 2D material TaIrTe4, exhibiting both a traditional Z
2 band gap at the charge neutrality point and a Van Hove singularity (VHS) induced correlated Z
2 band gap with weak doping. Inspired by the recent progress in theoretical understanding and experimental measurements, we predicted a promising dual QSHI in the counterpart material of the NbIrTe4 monolayer by first-principles calculations. In addition to the well-known band inversion at the charge neutrality point, two new band inversions were found after a CDW phase transition when the chemical potential is near the VHS, one direct and one indirect Z
2 band gap. The VHS-induced non-trivial band gap is around 10 meV, much larger than that from TaIrTe4. Furthermore, since the new generated band gap is mainly dominated by the 4d orbitals of Nb, electronic correlation effects should be relatively stronger in NbIrTe4 as compared to TaIrTe4. Therefore, the dual QSHI state in the NbIrTe4 monolayer is expected to be a good platform for investigating the interplay between topology and correlation effects.
Recent advances in surface charge dynamics in dielectric barrier discharge: future strategies for control and technological optimisation
Authors: Komuro Atsushi 
Published: February 2025

Abstract
Dielectric barrier discharges (DBDs) using atmospheric pressure plasma are utilised in various industries, including environmental remediation, semiconductor manufacturing, and energy technology. It is crucial to understand and regulate their properties for technological optimisation. Of particular significance is the surface charge generated by DBDs, as it is the primary physical factor that determines the electric field in the plasma, resulting in overcurrent suppression and radical formation. This study explores recent advancements in research concerning the dynamic properties of surface charge and examines future strategies for optimising DBDs and achieving real-time surface charge control.
Forecast analysis of astrophysical stochastic gravitational wave background beyond general relativity: a case study on brans-dicke gravity
Authors: Chen Ran , Li Zhao , Li Yin-Jie , Wang Yi-Ying , Niu Rui , Zhao Wen , Fan Yi-Zhong 
Published: February 2025

Abstract
Scalar-tensor gravity, exemplified by Brans-Dicke (BD) gravity, introduces additional scalar polarization modes that contribute scalar radiation alongside tensor modes.
We conduct a comprehensive analysis of how gravitational wave generation and propagation effects under Brans-Dicke gravity are encoded into the astrophysical stochastic gravitational wave background (AGWB).
We perform end-to-end analyses of realistic populations of simulated coalescing binary systems to generate AGWB mock data with third-generation gravitational wave detectors and conducted a complete Bayesian analysis for the first time.
We find the uncertainties in the population properties of binary black holes (BBH) significantly affect the ability to constrain BD gravity.
Furthermore, we explore the detectability of potential scalar backgrounds that originates from binary neutron star (BNS) and neutron-star-black-hole (NSBH) mergers, with NSBH systems expected to modify the spectral index of the scalar background and introduce oscillatory behavior.
We show that the observations of the AGWB enable the separation of mixed tensor and scalar polarization modes with comparable sensitivity to each mode.
However, the scalar background is expected to remain substantially weaker than the tensor background, even in scenarios where BD gravity exhibits significant deviations from general relativity (GR), resulting only upper limits can be placed on the scalar background.
We conclude that for ambiguous populations, employing waveform matching with individual sources provides a more robust approach to constrain BD gravity.
Spectroscopic and transition properties of strontium chloride
Authors: Wu Dong-Lan , Liu Bi-Kun , Zhou Wen-Tao , Chen Jia-Yun , Lai Zhang-Li , Liu Bo , Yan Bing 
Published: February 2025

Abstract
The spectroscopic and transition properties of strontium chloride (SrCl) are investigated based on a theoretical approach of ab initio quantum chemistry. The calculation accuracy is improved by introducing Davidson correction, core-valence correlation (CV), the scalar relativistic and spin-orbit coupling (SOC) effect. The results show that the spectroscopic constants of X2Σ+ and A2Π states are consistent with the experimental results. The spectroscopic and molecular constants of most highly excited electronic states have been reported for the first time. The permanent dipole moment (PDMs) and the spin orbit (SO) matrix element have a sudden change for the avoidance of crossing. The potential energy curves (PECs) of the 14 Λ-S states split into 30 Ω states. The splitting energy of A2Π is 290.76 cm-1, which has a little difference from the experimental value 295.597 cm-1. Finally, the transition properties are given, including transition dipole moment (TDMs), Franck-Canton factor (FCFs) and radiation lifetime. It is found that the calculated radiation lifetime is in the order of 10ns. The research will provide theoretical reference for the feasibility laser cooling of SrCl molecule.
Extension to the range of prefixes for binary multiples
Authors: Brown Richard J C 
Published: February 2025

Abstract
This letter summarises the history of prefixes for binary multiples and introduces the new binary prefixes that are now officially available for use following an update to the IEC 80000-13 documentary standard on Information Science and Technology, the successor to the document where the binary prefixes were originally introduced in 1999. These new binary prefixes mirror the new SI prefix multiples that were approved at the 27th CGPM in 2022. The difference between the numerical size of equivalent binary and decimal prefixes is highlighted, emphasizing the need to use the appropriate prefix type to ensure unambiguous communication, especially for data science and information technology applications where both sets of prefixes are regularly used together with the non-SI units bit and byte.
Evaluation of Timepix3 with a 1 mm thick silicon sensor as a Compton imaging polarimeter in the hard X-ray band
Authors: Jelinek Jindrich , Bergmann Benedikt , Smolyanskiy Petr 
Published: February 2025

Abstract
The present work demonstrates the usage of a Timepix3 with a 1 mm thick silicon sensor as a scattering polarimeter with simultaneous Compton-camera imaging. For this purpose, laboratory experiments were designed where the detector was placed at different scattering angles with respect to a plastic target that is irradiated with X-rays from a Hamamatsu microfocus tube (tube voltage 75 kV, tube current 60 µA). Photons scattered in the target at 90∘ are almost 100 % linearly polarized. Measurements in an energy range of 32.5–67.5 keV showed modulation factors above 70 %. Simulations of 100 % linearly polarized beams showed modulation factors μ
100 > 77 % in an energy range of 45–80 keV. The efficiency of detection has a maximum above 0.13 % at 45–50 keV. We implemented the origin ensemble with resolution recovery (OE-RR) algorithm for Compton camera imaging. The full width at half maximum (FWHM) of the image of 16–21∘ was achieved.
Biodegradable Mg-1%Ca alloy inhibits the growth of cervical cancer
Authors: Ouyang Yunshan , Cao Lingling , Zhao Qian , Yang Wang , Lin Chen 
Published: February 2025

Abstract
The traditional treatment for cervical cancer involves aggressive surgery combined with radiotherapy and chemotherapy. Nevertheless, these treatments have certain limitations and side effects, thus breakthroughs and advances are required in cervical cancer therapy. Magnesium alloy is a promising antitumor biomaterial with excellent biocompatibility and biodegradability. However, the potential effects of magnesium alloy on cervical tumors have not been extensively explored. Recent studies have demonstrated that adding a small amount of calcium to the magnesium matrix can reduce grain size and corrosion rate while providing good biocompatibility. We conducted in vivo and in vitro experiments to test the antitumor properties of Mg-1%Ca alloys. The results indicated that the Mg-1%Ca alloy released Mg2+ and OH- more slowly, inhibited the proliferation of SiHa and HeLa cells, induced apoptosis in tumor cells, disrupted the cytoskeleton, and inhibited cell migration and invasion. At the molecular level, Mg-1%Ca alloy&#xD;the MAPK/ERK signaling pathway. In the future, Mg-1%Ca may be employed in the treatment of cervical cancer as a novel adjuvant therapeutic material with anticancer function to prevent the occurrence and progression of cancer proliferation and metastasis.&#xD;
3D printed polycaprolactone/poly (L-lactide-co-ϵ-caprolactone) composite ureteral stent with biodegradable and antibacterial properties
Authors: Teng Yanjiao , Wang Xinyan , Song Lin , Yang Jianing , Hou Shike , Lv Qi , Jiang Li , Guan Yong , Shi Jie 
Published: February 2025

Abstract
The clinical application of biodegradable ureteral stents holds significant potential. There is an urgent need to develop new materials for ureteral stents to address the limitations related to performance degradation and antibacterial properties observed in current designs. Here, we developed a Polycaprolactone (PCL)/Poly (L-lactide-co-ϵ-caprolactone) (PLCL) composite ureteral stent by three-dimensional (3D) printing, which exhibits biodegradable and antibacterial properties. Silver nanoparticles (AgNPs) were bonded to the surface of the stent through the polymerization of dopamine (PDA) and coating with type I collagen (Col I). The ureteral stent (PP-PDA-Ag-Col) had a densely spiraled structure and higher hydrophilicity. The release behavior of silver ions from the stent was found to be slow and continuous when coated with AgNPs, which can enable long-term antibacterial effects after being implanted in vivo. Additionally, in vitro degradation experiments demonstrated that the different ratios of ureteral stents degraded slowly in artificial urine over 6 weeks without compromising functionality. The stent exhibits excellent hemocompatibility and cell compatibility. The subcutaneous implantation experiment in Sprague–Dawley rats showed that the PP-PDA-Ag-Col stent degraded slowly in vivo and had good biocompatibility. The stent PCL5/PLCL5 was the most promising ureteral stent regarding antibacterial, mechanical properties, and degradation. The novel 3D-printed PP-PDA-Ag-Col stent exhibits biocompatibility for safe in vivo transplantation and antibacterial properties that reduce reliance on antibiotics. Additionally, its biodegradability eliminates the need for secondary surgical removal, making it a promising option for the clinical application of ureteral stents.
Chitosan hydrochloride coated and nonionic surfactant modified niosomes: a better way for oral administration of semaglutide
Authors: Wang Ben , Su Zhengxing , Kuang Meiyan , Luo Yi , Xu Minhao , Sun Meng , Liu Xingyou , Guo Yue , Bai Lu , Wang Yu , Yan Xinlei , Xie Jing , Tang Yaqin 
Published: February 2025

Abstract
Diabetes is now a global chronic disease, with the number of people with diabetes expected to reach 643 million by the end of 2030. Semaglutide, a human glucagon-like peptide-1 (GLP-1) analogue with 94% similarity to human GLP-1, can promote insulin secretion and repress glucagon secretion in a glucose concentration-dependent manner, resulting in substantial improvement of blood glucose levels and reducing the risk of hypoglycemia in patients with type 2 diabetes. To improve the absorption efficiency of semaglutide in oral delivery, we developed chitosan hydrochloride-coated and nonionic surfactant-modified niosomes (CS.HCL-NSPEs-NIO) as a new way to encapsulate it. The results showed that CS.HCL-NSPEs-NIO could efficiently penetrate the cell junctions in the intestinal endothelium and therefore promote drug absorbance. In addition, gastrointestinal distribution studies revealed that CS. HCL-NSPEs-NIO could stay in the intestine for more than 4 hours, thus allowing for long-term glucose regulation. Effective reduction of blood glucose levels and weight loss were observed in db/db mice while no toxicity was detected in major organs. Overall, we suggest CS.HCL-NSPEs-NIO is a promising oral delivery agent to improve the hypoglycemic effect of semaglutide.