bluuebunny/crossref_metadata_2025_split huggingface dataset:
Investigating the potential of wine lees as a natural colorant and functional ingredient in jelly production
Authors: Gümüş Tuncay , Altan Kamer Deniz Damla , Kaynarca Gülce Bedis 
Published: September 2023

AbstractBACKGROUNDThe purpose of this study was to evaluate the potential of incorporating wine lees (WL), an inexpensive and widely available high‐value winery waste product, into gelatin‐based jellies to improve their technological and functional properties. We also aimed to evaluate the suitability of WL as a jelly colorant by comparing it with a commercial colorant.RESULTSWine lees were characterized for their anthocyanin, phenolic, antioxidant, and mineral content. Subsequently, physicochemical, functional, textural, rheological, and thermal analyses were conducted on soft candies containing 21, 14, and 7 g kg−1 WL (labeled as WL30, WL20, and WL10, respectively). The total phenolic, anthocyanin, antioxidant, and cupric‐reducing antioxidant capacity (CUPRAC) values of WL30 were determined as 57.80 ± 6.12 mg gallic acid equivalent per kilogram (GAE kg−1), 17.58 ± 0.36 mg malvidin‐3‐glucoside equivalent kg−1, 0.04 ± 0.01 μg mL−1, and 45.55 ± 1.00 mmol L−1 Trolox equivalent (TE), respectively. The control sample had the best rheological characteristics, including K′, G', and n*, as well as the greatest hardness value, followed by WL30. However, during the storage period, WL30 exhibited superior color stability and retained higher levels of phenolic and anthocyanin components in comparison with the control sample.CONCLUSIONWine lees have the potential to be utilized as a natural colorant and alternative flavoring agent in jelly production. © 2023 The Authors. Journal of The Science of Food and Agriculture published by John Wiley & Sons Ltd on behalf of Society of Chemical Industry.
Minority stress and mental health in lesbian, gay, bisexual, transgender, and queer survivors of sexual assault
Authors: Bedford Carter E. , Trotter Aoife M. , Potter Miracle , Schmidt Norman B. 
Published: September 2023

AbstractExtant research has shown that sexual violence disproportionately affects lesbian, gay, bisexual, transgender, and queer (LGBTQ+) individuals, conferring risk for the development of posttraumatic stress symptoms (PTSS) and related mental health conditions. However, little research has focused on specific vulnerabilities among LGBTQ+‐identified sexual assault (SA) survivors (e.g., minority stress) and their associations with post‐SA psychopathology. To address this gap, we examined associations between experiences of minority stress and post‐SA psychopathology in a sample of LGBTQ+ individuals who experienced SA (N = 92) and completed a battery of self‐report measures. Results revealed significant differences in internalized stigma, community connectedness, alcohol use, and cannabis use across sexual orientation and gender modality groups, ηp2 = .08–11. Additionally, regression analyses indicated that experiences of violence and victimization were significantly associated with higher PTSS, β = .31, p = .020; anxiety, β = .39, p = .003; and alcohol use severity, β = .31, p = .027, over and above other experiences of minority stress and psychopathology risk factors. Internalized stigma was significantly associated with cannabis use severity, β =.34, p = .011. Finally, community connectedness was significantly associated with lower anxiety symptom severity, β = −.42, p = .001. Although longitudinal work is needed, findings indicate that experiences of minority stress may serve as risk or maintenance factors for post‐SA psychopathology. These results offer important considerations for future treatment approaches tailored to LGBTQ+ survivors of SA.
Sialendoscopy Findings Associated with Positive Minor Salivary Gland Biopsy
Authors: Bertram Jessica , Nieri Chad , Reed Leighton , Gillespie M. Boyd 
Published: September 2023

ObjectivesTo determine the sialendoscopy findings associated with positive findings on minor salivary gland biopsy.Study DesignSingle‐center retrospective study.MethodsPatients ≥18 years old who underwent sialendoscopy from 2016 to 2022 and were evaluated for SS via labial minor salivary gland biopsy. Biopsy positive and negative patients were compared on the primary outcome measure of sialendoscopy findings. Data were abstracted from the sialendoscopy operative notes and included involved gland, location of ductal pathology, and the presence of scarring, stenosis, mucus plugs, webs, and dilations. Additional characteristics included demographics, presenting symptoms, caffeine or tobacco, use of drying medications, and need for additional treatments.ResultsThe final cohorts included 22 biopsy positive and 21 biopsy negative patients with a total of 42 glands in the biopsy positive and 37 glands in the biopsy negative groups. Biopsy positive patients were found to require dilation at the hilum and distal duct at significantly higher rates than biopsy negative patients (p < 0.0001). However, there was no statistical difference in scarring, stenosis severity, mucus, webs, or dilations between each group.ConclusionThe outcomes of this study suggest that there are no distinct sialendoscopy findings associated with biopsy positive patients. The presence of significant distal stenosis on sialendoscopy may be associated with positive minor salivary biopsy. Other endoscopic parameters are likely more consistent with non‐specific chronic sialadenitis.Level of Evidence3 Laryngoscope, 134:1183–1189, 2024
Balloon Eustachian Tuboplasty—A Feasible Double‐Blinded Sham Surgery Randomized Clinical Trial Protocol to Study Efficacy
Authors: Laakso Juha T. , Oehlandt Heidi , Kivekäs Ilkka , Harju Teemu , Jero Jussi , Sinkkonen Saku T. 
Published: September 2023

IntroductionBalloon Eustachian tuboplasty (BET) is used to treat obstructive Eustachian tube dysfunction (OETD) and recurrent otitis media with effusion (OME). However, there are no indisputable evidence of its efficacy. Here, we present a multicenter, double‐blinded, randomized, placebo‐controlled trial (MDRCT) design to evaluate the efficacy of BET, and the results of a pilot trial with 3‐ and 12‐months' follow‐up.Material and MethodsThis was a prospective MDRCT. For a pilot study, OETD (n = 10) and OME (n = 5) patients were recruited and followed. Detailed inclusion and exclusion criteria were used. Participants were randomized at beginning of the operation to active or sham surgery. All procedures were performed under local anesthesia. Controls were performed in double‐blinded manner (both patient and physician), at 3 and 12 months after the procedure.ResultsAltogether, 20 ears were treated and followed for 12 months, including 14 active BETs and 6 sham surgeries. Both the active and sham surgery were performed under local anesthesia without problems or deviations from the protocol. There were no differences in the preoperative symptoms (ETDQ‐7) or objective measures (tympanometry, Valsalva and Toynbee maneuvers, tubomanometry, Eustachian tube score) between active and sham surgery arms. During follow‐up, we noticed largely similar reduction in subjective symptoms and improvement in Eustachian tube score both in active and sham surgery arms.ConclusionsThe pilot study demonstrates that our MDRCT protocol is feasible, and that blinded RCTs are dearly needed to objectively measure the efficacy of BET.Level of Evidence2 Laryngoscope, 134:1874–1881, 2024
A new index for the rapid generation of chlorophyll time series from hyperspectral imaging of sediment cores
Authors: Ghanbari Hamid , Zilkey David R. , Gregory‐Eaves Irene , Antoniades Dermot 
Published: September 2023

AbstractTime series analyses of pigment concentrations are key to understanding past aquatic ecosystem dynamics. As lake sediments provide a window into longer‐term changes, innovative paleolimnological chlorophyll quantification could provide impactful insights into past environmental processes. Lab‐based hyperspectral imaging of sediment cores is an emerging technique to develop rapid, non‐destructive, high‐resolution chlorophyll inferences but it requires more extensive vetting. Despite recent advances in model development, there is still a knowledge gap about the reliability of chlorophyll models when applied in lakes with diverse properties, as well as the potential confounding effects of physical sediment properties on these models. We assessed the performance of 23 chlorophyll indices based on paired measurements collected via hyperspectral imaging and spectrophotometry for 202 samples spread across seven Canadian lake sediment cores. The best performance was by a new index based on the wavelength of the red‐edge minimum point (λREMP). We tested the applicability of λREMP to a broad range of sediment cores using a database of 116 cores, and found the index to provide reliable reconstructions of ƩChl (i.e., chlorophyll a and b and their degradation products) trends in 84% of sites. Further analyses indicated that sediment characteristics including particle size, organic matter content, water content, and density had no systematic impact on ƩChl, but greater sediment brightness did increase ƩChl inferences from hyperspectral images. Hyperspectral core scanning is poised to facilitate the generation of high‐resolution chlorophyll time series data, which could greatly improve our understanding of trajectories of change from the local to global scales.
Silicon Programmable Photonic Circuits Based on Periodic Bimodal Waveguides
Authors: Torrijos‐Morán Luis , Pérez‐Galacho Diego , Pérez‐López Daniel 
Published: September 2023

AbstractProgrammable photonic circuits are dense assemblies of waveguide meshes in which the flow of light can be reconfigured by software to implement a wide variety of functions, ranging from radiofrequency filtering to optical computing. However, most programmable architectures to date rely on rather bulky Mach‐Zehnder interferometers (MZIs), which are not suitable for large‐scale and high‐density integration. Here, an alternative approach to MZI‐based programmable photonic circuits by using slow‐light‐enhanced periodic bimodal waveguides (PBWs) as programmable units is presented. This study experimentally demonstrates low‐loss short tuning elements of 30× 1.7 µm2 in area, achieving a two‐orders of magnitude integration density improvement compared to conventional MZIs. A rectangular arrangement of these tunable units is proposed for 3× 3 and 4× 4 matrix multiplication operations to design a feedforward circuit with a footprint of only 100× 250 µm2. Finally, the performance trade‐off and benchmark with alternative programmable unit cells are analyzed in order to address the ever‐growing demand for large computing requirements in next‐generation applications such as artificial intelligence and quantum information processing.
Curli Amyloid Fibers in Escherichia coli Biofilms: The Influence of Water Availability on their Structure and Functional Properties
Authors: Siri Macarena , Mangiarotti Agustín , Vázquez‐Dávila Mónica , Bidan Cécile M. 
Published: September 2023

AbstractEscherichia coli biofilms consist of bacteria embedded in a self‐produced matrix mainly made of protein fibers and polysaccharides. The curli amyloid fibers found in the biofilm matrix are promising versatile building blocks to design sustainable bio‐sourced materials. To exploit this potential, it is crucial to understand i) how environmental cues during biofilm growth influence the molecular structure of these amyloid fibers, and ii) how this translates at higher length scales. To explore these questions, the effect of water availability during biofilm growth on the conformation and functions of curli is studied. Microscopy and spectroscopy are used to characterize the amyloid fibers purified from biofilms grown on nutritive substrates with different water contents, and micro‐indentation to measure the rigidity of the respective biofilms. The purified curli amyloid fibers present differences in the yield, structure, and functional properties upon biofilm growth conditions. Fiber packing and β‐sheets content correlate with their hydrophobicity and chemical stability, and with the rigidity of the biofilms. This study highlights how E. coli biofilm growth conditions impact curli structure and functions contributing to macroscopic materials properties. These fundamental findings infer an alternative strategy to tune curli structure, which will ultimately benefit engineering hierarchical and functional curli‐based materials.
Consumers' responses to personalized service from medical artificial intelligence and human doctors
Authors: Zhang Yiran (Eileen) , Tan Wenying , Lee Eun‐Ju 
Published: September 2023

AbstractArtificial intelligence (AI) is transforming healthcare, yet little is known about how consumers experience medical AI and make decisions about using these providers for follow‐up care. We take an interdisciplinary approach that combines behavioral and neuroimaging experiments to determine how anthropomorphism and personalization influence consumers' well‐being and their decisions about a provider for follow‐up care. Study 1 finds that, regardless of the type of medical provider used, consumers are likely to experience a heightened sense of well‐being after a highly personalized medical consultation. However, regardless of whether the first interaction is highly personalized or not, they prefer follow‐up visits with a human doctor, as mediated through empathy. Study 2 finds that, regardless of the type of medical provider used, the anterior cingulate cortex shows greater activation in a highly (vs. low) personalized interaction, the activation of which is also correlated with consumers' willingness to revisit that provider. Furthermore, the temporal occipital fusiform cortex shows greater activation in consultations with a human doctor (vs. medical AI), regardless of the interaction's level of personalization. The level of activation is also correlated with consumers' willingness to revisit with the initial provider. The findings suggest that medical AI cannot currently replace human doctors and that human doctors remain consumers' choice for medical consultations and treatment.
Walls have ears: Word‐of‐mouth diffusions in targeted promotions decrease targeted customer retention
Authors: Chang Yaping , Li Xinlan , Wang Xingyu 
Published: September 2023

AbstractRecent research suggests that targeted promotions have positive effects on targeted customers and negative effects on untargeted customers. However, the advent of market transparency increases the likelihood of untargeted customers' negative reactions reaching targeted customers. We examine this issue with four online experiments and find that for promotions targeted on infrequent customers, exposure (vs. no exposure) to negative word‐of‐mouth (WOM) from untargeted frequent customers does not affect targeted infrequent customers' current purchase intentions, but does reduce their intentions to remain with the marketer. Furthermore, we identify two moderators, such that when managers mention luck in the promotion delivery stage and when managers respond to negative online word‐of mouth (eWOM) from untargeted frequent customers and mention promotions targeted on frequent customers, they mitigate this negative effect. Our findings offer a new direction for the undesired effect of targeted promotions and identify the possibility that WOM diffusion reduces targeted customers' retention. We also provide valuable managerial insights on how to mitigate the negative effects of targeted promotions by framing the promotion as a result of luck, and by responding to and mentioning promotions targeted on frequent customers to negative eWOM from untargeted customers.
Bioinspired Engineering of Fillable Gradient Structure into Flexible Capacitive Pressure Sensor Toward Ultra‐High Sensitivity and Wide Working Range
Authors: Hong Weiqiang , Guo Xiaohui , Zhang Tianxu , Liu Yiyang , Yan Zihao , Zhang Anqi , Qian Zhibin , Wang Junyi , Zhang Xinyi , Jin Chengchao , Zhao Jingji , Liu Tiancheng , Hong Qi , Xu Yaohua , Xia Yun , Zhao Yunong 
Published: September 2023

AbstractTactile sensing is required for electronic skin and intelligent robots to function properly. However, the dielectric layer's poor structural compressibility in conventional pressure sensors results in a limited pressure sensing range and low sensitivity. To solve this issue, a flexible pressure sensor with a crocodile‐inspired fillable gradient structure is provided. The fillable gradient structure and grooves in the pressure sensor accommodate the deformed microstructure that permits the enhancement of the media layer compressibility via COMSOL finite element simulation and optimization. The pressure sensor exhibits a high sensitivity of up to 0.97 k Pa−1 (0–4 kPa), a wide pressure detection range (7 Pa–380 kPa), and outstanding repeatability. The sensor can detect Morse code, robotic grabbing, and human motion monitoring. As a result, flexible sensors with a bionic fillable gradient structure pave the way for wearable devices and offer a novel method for achieving highly precise tactile perception.
Hydrogels for Chemical Sensing and Biosensing
Authors: Li Haizheng , Dai Chunai , Hu Yuandu 
Published: September 2023

AbstractThe development and synthesis of hydrogels for chemical and biosensing are of great value. Hydrogels can be tailored to its own physical structure, chemical properties, biocompatibility, and sensitivity to external stimuli when being used in a specific environment. Herein, hydrogels and their applications in chemical and biosensing are mainly covered. In particular, it is focused on the manner in which hydrogels serve as sensing materials to a specific analyte. Different types of responsive hydrogels are hence introduced and summarized. Researchers can modify different chemical groups on the skeleton of the hydrogels, which make them as good chemical and biosensing materials. Hydrogels have great application potential for chemical and biosensing in the biomedical field and some emerging fields, such as wearable devices.
A loophole in soap dispensers mediates contamination with Gram‐negative bacteria
Authors: Lucassen Ralf , van Leuven Nicole , Bockmühl Dirk 
Published: September 2023

AbstractLiquid soap dispensers are widely used in domestic and clinical settings. In previous studies, the risk of bacterial contamination of refillable systems was pointed out and a bacterial contamination rate of 25%, with values of up to 108 colony‐forming units/mL (CFU/mL), was reported. However, the route of contamination remains elusive. To address this point, we determined the microbial contamination of refillable standard pump dispensers and nonrefillable press‐dispenser systems. Following the collection of 104 liquid soap dispensers from hotel rooms across Germany, bacterial counts were determined. Isolates of samples containing nonfastidious Gram‐negative(lac−) bacteria were further analyzed by the Vitek 2 system for the determination of species. 70.2% of the refillable pump dispensers (mean total bacterial count = 2.2 × 105 CFU/mL) but only 10.6% of the nonrefillable press dispensers, were contaminated (mean total bacterial count = 1.5 × 101 CFU/mL). Of samples containing nonfastidious Gram‐negative(lac−) bacteria, Pluralibacter gergoviae was present in 41.7%, Pseudomonads (Pseudomonas aeruginosa and Pseudomonas putida) in 25%, Serratia marcescens in 16.7%, and Klebsiella oxytoca and Pasteurella testudinis in 8.3%. After the initial assessment, we contaminated different dispensing systems with P. aeruginosa/P. gergoviae, to reveal the route of contamination and identied the pressure release of standard pump dispensers as the loophole for microbial contamination.
Turbocharging as a strategy to boost extended perforator flap vascularity in head and neck reconstruction—A report of two cases
Authors: Ramachandran Savitha , Chang Chao‐Wei , Wang Yu‐Chi , Huang Chao‐Hsin , Chew Khong Yik , Kuo Yur‐Ren 
Published: September 2023

AbstractPerforator flap has been applied as the most common flap for soft tissue defect reconstruction. Here, we presented two cases using turbocharging procedure of perforator to perforator as a salvage strategy. The first case was a 54‐year‐old male with recurrent squamous cell carcinoma (SCC) in the left buccal area and mouth floor. A 6 × 22 cm posteromedial thigh (PMT) flap was designed for reconstruction. The two eccentric perforators of the PMT flap could not conjoin together during dissection nearby the main pedicle of profunda femoral artery (PFA) resulting in inadequate perfusion. Side branched stump before clipped the branch of distal perforator was preserved, then the proximal perforator was divided and end‐to‐end anastomosis of side branch of distal perforator was done successfully. The second case was a 52‐year‐old male underwent wide composite excision of right tongue SCC. After excision, anterolateral thigh (ALT) flap around 7 × 15 cm was harvested from left thigh and two perforators were included which one tiny perforator supplied by the descending branch (DB) and the other major perforator originated from oblique branch (OB) of lateral circumflex femoral artery (LCFA). However, the OB main perforator injury showed inadequate perfusion of flap. We trimmed the injury zone of OB perforator, and shift to re‐anastomosis of OB perforators to side branch of DB of LCFA directly. The flap demonstrated excellent perfusion immediately after the operation, and it exhibited complete survival 2 weeks postoperatively. These results indicated that the turbocharging procedure, from perforator to perforator, could serve as a strategy for salvaging perfusion‐compromised flaps, especially in cases of eccentric perforators or perforator injury resulting in inadequate perfusion.
Sulforaphane Mitigates High‐Fat Diet‐Induced Obesity by Enhancing Mitochondrial Biogenesis in Skeletal Muscle via the HDAC8‐PGC1α Axis
Authors: Yang Hee , Hur Gihyun , Lee Tae Kyung , Kim Jong‐Eun , Kim Jong Hun , Kim Jong Rhan , Kim Jiyoung , Park Jung Han Yoon , Lee Ki Won 
Published: September 2023

ScopeHistone deacetylases (HDACs) play a crucial role in the transcriptional regulation of various genes which can contribute to metabolic disorders. Although sulforaphane (SFN), a natural HDAC inhibitor, has been reported to alleviate obesity in humans and mice, the specific mechanisms and how HDACs contribute to SFN's anti‐obesity effects remain unclear.Methods and resultsOral administration of SFN in mice fed high‐fat diet increases peroxisome proliferator activating receptor γ coactivator (PGC1α)‐induced mitochondrial biogenesis in skeletal muscle. Among HDACs, SFN specifically inhibits HDAC8 activity. SFN enhances mitochondrial DNA and adenosine triphosphate (ATP) production in C2C12 myotubes, similar to the action of PCI34051, a synthetic HDAC8‐specific inhibitor. These effects are mediated by increased expression of PGC1α via upregulation of cAMP response element binding (CREB, Ser133) phosphorylation and p53 (Lys379) acetylation. These SFN‐induced effects are not observed in cells with a genetic deletion of HDAC8, suggesting the existence of a regulatory loop between HDAC8 and PGC1α in SFN's action.ConclusionSFN prevents obesity‐related metabolic dysregulation by enhancing mitochondrial biogenesis and function via targeting the HDAC8‐PGCα axis. These results suggest SFN as a beneficial anti‐obesity agent providing new insight into the role of HDAC8 in the PGC1α‐mediated mitochondrial biogenesis, which may be a novel and promising drug target for metabolic diseases.