bluuebunny/crossref_metadata_2025_split huggingface dataset:
Sternocleidomastoid muscle-splitting method for high cervical carotid endarterectomy: illustrative cases
Authors: Sato Atsushi , Sasaki Tetsuo , Ogiwara Toshihiro , Hongo Kazuhiro , Horiuchi Tetsuyoshi 
Published: January 2024

BACKGROUND
The number of cervical carotid endarterectomies (CEAs) has decreased as carotid artery stenting (CAS) has increased. However, CEA and CAS both have advantages and disadvantages; therefore, appropriate procedures must be selected for individual patients. High-positioned carotid artery stenosis presents technical challenges for CEA and is occasionally managed by performing CAS. However, CAS is associated with a high risk of thrombosis in patients with soft plaques, suggesting a clinical need for a better procedure. Consequently, appropriate surgical treatment for patients requiring high-level CEAs is essential.

OBSERVATIONS
In this study, a novel and straightforward method was devised. The primary concept underlying this technique is separation of the sternocleidomastoid muscle (SCM) from other anatomical structures to ensure a wider surgical field. By anatomically separating the SCM into the sternal and clavicular head groups, the objective of the wider surgical field can be met. Herein, we report technical innovations in high-positioned carotid artery stenosis and evaluate their efficacy in two patients.

LESSONS
In conclusion, high CEA surgery using this new method is valuable and may eliminate barriers to more advanced approaches.
La seguridad alimentaria del Pueblo Wiwa. Un análisis de la situación en el contexto de la Agenda 2030
Authors: Mejía Erotida Beatríz 
Published: January 2024

Posiblemente, el objetivo más importante de la Agenda 2030 es el hambre cero. No obstante, existe preocupación por la imposibilidad de cumplir con tener una seguridad alimentaria en el mundo. Por supuesto, el escenario en Colombia no dista de lo mencionado y peor aún en poblaciones como la Wiwa. Uno de los pueblos indígenas menos visibilizados del país, víctima de desplazamientos forzados y de vulneración de sus derechos, quienes han debido realizar cambios en su alimentación por la adaptación a nuevos territorios.
Con este escrito se pretende analizar la situación de seguridad alimentaria del Pueblo Wiwa. Esto, teniendo presente que Colombia es uno de los 192 países miembros de las Naciones Unidas, que ha enmarcado sus políticas al cumplimiento de los ODS y a la Agenda 2030. Para ello, se asume el enfoque cualitativo y la etnografía como método, para el acercamiento y contacto con los actores en su contexto.
Advertising Image Taking Techniques As A Promotional Means In Increasing Consumer Interest
Authors: Batubara Ayu Azzahra , Hafizh Muhammad Abdurrahman , Jannah Miftahul , Sitompul Surganda , Ikhwan Ali 
Published: January 2024

Dengan adanya kemajuan teknologi yang mana telah mempengaruhi meningkatnya kualitas foto yang dihasilkan untuk mempromosikan produk yang akan dipasarkan. Maka tujuan dari Artikel ini ialah agar para photofraper iklan produk mampu meningkatkan kemampuan serta keahliannya dalam mengabadikan objek gambar yang diambil dengan menghasilkan sebuah foto yang inovatif dan artistic [1]. Dengan meningkatnya kualitas foto yang dihasilkan oleh photofraper maka semakin menarik konsumen untuk memberi produk yang dipromosikan oleh sipenjual. Untuk mencapai itu maka diperlukannya penguasaan kamera oleh photofraper dan itu adalah hal yang mutlak. Yaitu mulai dari bagian kamera serta teknik signifikan serta yang nantinya akan menghasilkan karya foto produk yang terbaik dan menarik minat konsumen [2].
O desenvolvimento do raciocínio geográfico por meio do ensino por investigação
Authors: De Morais Jackson Junio Paulino 
Published: January 2024

Este trabalho desenvolvido junto a estudantes da educação básica se debruça sob a potencialidade do ensino por investigação frente ao desenvolvimento do raciocínio geográfico. Aqui foram reunidas experiências e interpretações, visando contribuir para a reflexão sobre a estruturação da prática de ensino, a partir de situações geográficas voltadas à construção de interpretações da espacialidade do fenômeno. A análise dos dados se deu em diálogo com a perspectiva de raciocínio geográfico preconizado por Roque Ascenção e Valadão (2014, 2017, 2018) e Silva (2021), e ensino por investigação por De Morais (2022). Percebeu-se que a utilização do ensino por investigação favoreceu o estudo exploratório da situação geográfica selecionada para a execução da sequência didática junto aos sujeitos de pesquisa, que por sua vez, elaboraram sistematizações potentes por meio do raciocínio geográfico.
Entrevista com a professora Lana Cavalcanti
Authors: Scalercio Vitor SOARES 
Published: January 2024

Professora Titular da Universidade Federal de Goiás, Lana Cavalcanti é um dos principais expoentes da pesquisa da educação geográfica. Sua trajetória foi pioneira uma vez que cumpriu importante papel no estabelecimento do campo no Brasil quando a geografia escolar ainda buscava o seu espaço no início da década de 1990. De lá para cá, o campo se consolidou e suas reflexões têm acompanhado os diferentes movimentos e reorientações de agendas e preocupações.
Recentemente no ano de 2019 lançou seu último livro intitulado “Pensar pela Geografia: ensino e relevância social”, que além de questões sobre o processo de ensino e aprendizagem, lança luz sobre o estatuto epistemológico da ciência ao afirmar que a Geografia serve para pensar, frisando assim a importância do “pensamento geográfico”. Assim como seus textos, a conversar com a professora Lana Cavalcanti é leve, clara e muito preocupada com uma geografia viva que acontece diariamente nas salas de aula. Na entrevista, Lana faz um balanço sobre a formação do campo, seu panorama atual e compartilha suas preocupações diante de projeções futuras.
PENGEMBANGAN VISUAL DRAMA TARI PANJI PADA VIDEO KLIP MUSIK METAL KELOMPOK DJIWOASTRA
Authors: Manggala Bondan Aji , Kiswanto Kiswanto 
Published: January 2024

Kegiatan pengembangan visual Drama Tari Panji bertujuan untuk merealisasikan konsep dan gagasan visual dalam pertunjukan musik (konser) kelompok Djiwoastra pada karya lagu terakhir yang berjudul “Panji”. Keterlibatan penulis dalam proyek ini adalah sebagai salah satu produser video klip musik, serta berperan menjadi fasilitator gagasan visual Drama Tari Panji untuk pertunjukan musik kelompok Djiwoastra. Kegiatan dilakukan melalui metode partisipatoris yang berfokus pada upaya penemuan model pendekatan proses dan hasil (produk) kekaryaan seni pertunjukan yang berbasis pada internalisasi keberagaman pengalaman, selera, gaya, dan kompetensi dari para personil dan pendukung karya. Pengembangan visual Drama Tari Panji diharapkan dapat merepresentasikan musik metal Nusantara yang berwujud dalam simbol-simbol visual. Hasil dari kegiatan kekaryaan ini dapat membentuk pengalaman kreatif bagi penguatan ketrampilan kelompok Djiwoastra yang dapat dimanfaatkan lebih lanjut untuk mengatasi permasalahan dan tantangan kreativitas dalam pengembangan visual video klip pertunjukan musik metal Nusantara yang memperpadukan antara estetika Timur dan Barat.
Using Emr In A Corporate Hospital: Healthcare Providers Perspective From Bangladesh
Authors: Hossain Md Emam , Riaz Baizid Khoorshid , Islam Md Ziaul 
Published: January 2024

Background: An Electronic Medical Record (EMR) is an essential tool for delivering high-quality healthcare in a hospital. In recent years, hospitals have increased their investment in EMRs to improve the level of integrated management of information. The purpose of this study was to explore the perspectives of using EMR among healthcare providers (HCPs) in a corporate hospital in Bangladesh.
Methods: This cross-sectional study was conducted among 153 HCPs (doctors, nurses, lab technicians, drug dispensers, billing managers, and administrative personnel) who have access to EMR and working in a selected corporate hospital of Dhaka city. The study period was January to December 2019. HCPs were selected by convenience sampling technique. Data were collected by face-to-face interview using semi structured questionnaire. Data analysis was done by IBM SPSS software. Ethical issues were maintained strictly.
Result: Study revealed that 59.5% HCPs were in the age group of 18-29 years with the mean age being 29.26 (±7.58) years. Only 32.7% HCPs had previous experience of using this type of software before working in the current hospital and 62.7% got technical training on EMR within the current hospital. The majority (81.7%) of the HCPs found that the technical training was effective for using the EMR software. The difficulty of using EMR was significantly associated with the age (p<0.001), gender (p<0.001), professional status (p<0.001) and highest level of education (p<0.001) of the HCPs. HCPs ability to overcome job related challenges was significantly associated with the professional status of them (p<0.001). HCPs perception regarding effectiveness of EMR was found significantly associated with their place of technical training (p=0.004) and duration of the training (p=0.012).
Conclusion: EMR can be a helpful tool for the health service providers to provider health services at the corporate hospitals. Digital literacy need to be increased among the HCPs to ensure effective use of EMRs. Regular maintenance and upgrades of the technology infrastructure are necessary for advanced record-keeping and quality service.
JOPSOM 2021; 41(2):12-19
Evaluation on the insecticidal action of polyphenolic compound from Streblus asper (Lour.) on the red cotton bug, Dysdercus cingulatus (Fab.) (Hemiptera, Pyrrhocoridae)
Authors: Anila L. , Hashim M.S. 
Published: January 2024

The study aims to evaluate oxidative stress and the activity of acetylcholinesterase (AChE), upon applying polyphenolic bioinsecticide isolated from Streblus asper (PBSA) at a concentration of 0.595 ?g/insect (LD50) by topical application on Dysdercus cingulatus Fabricius (Red cotton bug- Hemiptera, Pyrrhocoridae). The results demonstrated that the active fraction exhibited significant inhibition in activities of AChE, antioxidant enzymes and Glutathione-S-transferase (GST) and a significant increase in the lipid peroxides (MDA/ TBARS) which led to the fact that D. cingulatus became more susceptible to the tested PBSA. The study has provided basic information on the mechanism of action of PBSA that will be promising to develop effective alternatives to synthetic insecticides.
Evaluation of pongamia oil soap against red spider mites, Tetranychus urticae Koch and its effect on mite predators in brinjal ecosystem
Authors: Jeevitha P. , Sreekumar K.M. , Deka Mukul Kumar 
Published: January 2024

The efficacy of pongamia oil soap was tested on red spider mites and on its predators (rove beetle, Oligota sp. and predatory gall midge, Feltiella acarisuga Vallot). Pongamia oil soap at 0.6, 1, 2 and 3 per cent along with neem oil 0.6 per cent, soap solution 0.5 per cent and thiamethoxam 25 WG were investigated and observations were recorded on, a day prior to and, 1, 3, 5, 7 and 14 days after spray application. The results revealed that pongamia oil soap @ 3, 2 and 1 per cent shown mite population reduction up to 86.50, 84.57 and 79.27 per cent respectively. Richness of mite predators didn’t vary significantly at one day after spray and the maximum population was observed in soap solution - (4.33/5 plants). Population of mite predators was relatively high at 14 days after spray with soap solution (35.67 per five plants) which was at par with pongamia oil soap @ 0.6, 1 and 2 per cent.
High-level expression of leghemoglobin in Kluyveromyces marxianus by remodeling the heme metabolism pathway
Authors: Tian Tian , Wu Xinwei , Wu Pingping , Lu Xinyi , Wang Qi , Lin Yifan , Liu Canjie , Zhou Jungang , Yu Yao , Lu Hong 
Published: January 2024

Soy leghemoglobin, when bound to heme, imparts a meat-like color and flavor and can serve as a substitute for animal-derived proteins. Enhancing cellular heme synthesis improves the recombinant expression of leghemoglobin in yeast. To achieve high-level expression of leghemoglobin A (LBA) in Kluyveromyces marxianus, a food-safe yeast, large-scale heme synthesis modules were transferred into K. marxianus using yeast artificial chromosomes (KmYACs). These modules contained up to 8 native and heterologous genes to promote the supply of heme precursors and downstream synthesis. Next, eight genes inhibiting heme or LBA synthesis were individually or combinatorially deleted, with the lsc1Δssn3Δ mutant yielding the best results. Subsequently, heme synthesis modules were combined with the lsc1Δssn3Δ mutant. In the resulting strains, the module genes were all actively expressed. Among these module genes, heterologous S. cerevisiae genes in the downstream heme synthesis pathway significantly enhanced the expression of their counterparts in K. marxianus, resulting in high heme content and LBA yield. After optimizing the medium recipe by adjusting the concentrations of glucose, glycine, and FeSO4·7H2O, a heme content of 66.32 mg/L and an intracellular LBA titer of 7.27 g/L were achieved in the engineered strain in a 5 L fermentor. This represents the highest intracellular expression of leghemoglobin in microorganisms to date. The leghemoglobin produced by K. marxianus can be utilized as a safe ingredient for plant-based protein products.
Coyote scat in cities increases risk of human exposure to an emerging zoonotic disease in North America
Authors: Raymond Sage , Steckler Deanna K. , Seguin M. Alexis , St. Clair Colleen Cassady 
Published: January 2024

IntroductionZoonoses associated with urban wildlife are increasingly concerning for human health and include the recent emergence of alveolar echinococcosis (AE) in North America. AE develops following infection with the tapeworm Echinococcus multilocularis. In Alberta, up to 65% of urban coyotes (Canis latrans) are infected with E. multilocularis, and infected scats contain eggs that can be accidentally ingested by people. Our goal was to determine the predictors of infection prevalence and intensity in coyote scats in Edmonton, Canada, and to identify the predictors of coyote scat deposition and content, especially as related to anthropogenic food sources and infrastructure.MethodsTo study infection prevalence and intensity, volunteers collected 269 scats, which were tested for E. multilocularis using polymerase chain reaction. We compared infection prevalence and shedding intensity by habitat and scat content. To determine predictors of scat presence and content, we used snow tracking to identify 1263 scats. We compared landscape characteristics at scats and available points, and among scats with different contents. We used negative binomial regression to predict scat abundance in city-delineated green spaces.Results26.0% of tested scats were positive for E. multilocularis (n = 70), and infection was twice as common as expected near compost and 1.3x more common than expected when scats contained anthropogenic food. Scats were more common than expected near other scats (80% within 1 m of scats, 27% at 11.5 m), buildings (19% at buildings, 16% at 80 m), and the camps of people experiencing homelessness (24% at camps, 20% at 60 m). Scats frequently contained fruit (52.9%), anthropogenic material (36.7%), and birdseed (16.0%), and scats containing anthropogenic material often occurred near human infrastructure, supporting a relationship between anthropogenic attractants and scat accumulation.DiscussionThese results suggest that abundant food sources and anthropogenic food increase coyote aggregation, increasing both scat abundance and infection rates, which in turn increases risk of exposure to zoonotic parasites for humans. Risk to humans might be reduced by preventing coyote access to anthropogenic and aggregated food sources and educating people who are likely to encounter infected soil or vegetation, including gardeners, park users, and people experiencing homelessness.
Circulating erythroferrone has diagnostic utility for acute decompensated heart failure in patients presenting with acute or worsening dyspnea
Authors: Appleby Sarah , Frampton Chris , Holdaway Mark , Chew-Harris Janice , Liew Oi Wah , Chong Jenny Pek Ching , Lewis Lynley , Troughton Richard , Ooi Shirley Beng Suat , Kuan Win Sen , Ibrahim Irwani , Chan Siew Pang , Richards A. Mark , Pemberton Christopher J. 
Published: January 2024

ObjectivesIn dyspneic patients with atrial fibrillation (AF) or obesity, the diagnostic performance of NT-proBNP for acute heart failure is reduced. We evaluated the erythroblast derived protein erythroferrone (ERFE) as an ancillary biomarker for the diagnosis of acute decompensated heart failure (ADHF) in these comorbid subgroups in both Western and Asian populations.MethodsThe diagnostic performance of ERFE (Intrinsic Lifesciences) and NT-proBNP (Roche Cobas e411) for ADHF was assessed in 479 New Zealand (NZ) and 475 Singapore (SG) patients presenting with breathlessness.ResultsPlasma ERFE was higher in ADHF, compared with breathlessness from other causes, in both countries (NZ; 4.9 vs. 1.4 ng/ml, p &lt; 0.001) and (SG; 4.2 vs. 0.4 ng/ml, p = 0.021). The receiver operating characteristic (ROC) areas under the curve (AUCs) for discrimination of ADHF were reduced in the NZ cohort compared to SG for ERFE (0.75 and 0.84, p = 0.007) and NT-proBNP (0.86 and 0.92, p = 0.004). Optimal cut-off points for ERFE yielded comparable sensitivity and positive predictive values in both cohorts, but slightly better specificity, negative predictive values and accuracy in SG compared with NZ. In patients with AF, the AUC decreased for ERFE in each cohort (NZ: 0.71, n = 105, SG: 0.61, n = 44) but increased in patients with obesity (NZ: 0.79, n = 150, SG: 0.87, n = 164).ConclusionsCirculating ERFE is higher in patients with ADHF than in other causes of new onset breathlessness with fair diagnostic utility, performing better in Asian than in Western patients. The diagnostic performance of ERFE is impaired in patients with AF but not patients with obesity.
An audit of medullary thyroid carcinoma from a tertiary care hospital in northwest India
Authors: Chakraborty Ananda Mohan , Rai Ashutosh , Pal Rimesh , Mukherjee Soham , Dahiya Divya , Kumar Rajinder , Saikia Uma Nahar , Panda Naresh Kumar , Bhadada Sanjay Kumar , Dutta Pinaki 
Published: January 2024

IntroductionMedullary thyroid carcinoma (MTC) is a rare thyroid malignancy originating from parafollicular C cells. It accounts for 5%–10% of all thyroid malignancies.MethodsAn ambispective analysis of pathologically proven MTC presented in a tertiary care hospital in northwest India was performed after considering demography, clinical manifestation, RET mutation status, management, and outcome as denominators.ResultsAmong 2,735 thyroid malignancy cases who presented to our institute in the last 10 years (2012–2022), 78 (3%) had MTC with a mean age of presentation of 43 ± 11 years; 60% of them were female. The median duration of symptoms was 23 months (IQR 12–36 months). The most common presenting complaint was goiter with lymphadenopathy (80.8%). Among the atypical presentations, one each had ectopic Cushing’s syndrome, hypertensive crisis in pregnancy due to pheochromocytoma, synchronous chondrosarcoma, and Von Hippel–Lindau disease spectrum. Median calcitonin and carcinoembryonic antigen (CEA) levels at presentation were 1,274 pg/mL (n = 64) and 149 ng/mL (n = 39), respectively. Twenty-two patients were germline RET mutation-positive, and they presented at a younger age. Majority of the patients presented with stage IV disease. Surgery was the primary modality of therapy. Twenty-nine patients received radiotherapy and 25 patients received tyrosine kinase inhibitors (TKIs). Nine patients received peptide receptor radiotherapy (PRRT) with Lu-177 with neoadjuvant capecitabine. Median progression-free survival (PFS) was 60 months. Patients without structurally and biochemically residual disease and stable disease after the first modality of therapy (Log-rank 11.4; p = 0.004) had a better PFS. Female patients (Log-rank: 9.5; p = 0.002) had a better PFS than male patients.ConclusionThis study showed that MTC comprises 3% of thyroid malignancies with a female preponderance. RET mutation-positive patients had a younger age at presentation. Surgery was the first-line therapy. Radiotherapy, TKI, and PRRT were given as a part of second-line or third-line therapy due to persistent disease and/or disease recurrence. The median PFS was better in female patients and in patients who had no residual lesions and stable disease after the primary modality of therapy.
Effects and safety of Ginkgo biloba on blood metabolism in type 2 diabetes mellitus: a systematic review and meta-analysis
Authors: Zou Huimin , Fang Jingxian , Han Yu , Hu Xue , Meng Jian , Huang Fang , Xu Hui , Lu Chengfei , Wang Yiwen , Zhang Lili , Dong Xiaohong , Yu Yanmei , Guo Yu , Gu Qing , Wang Suijun 
Published: January 2024

BackgroundThere has existed controversy regarding the use of Ginkgo biloba (GKB) for blood metabolism among type 2 diabetes mellitus(T2DM) patients, and we tried to analyze the effects and safety of GKB on T2DM patients.MethodsWe conducted a literature search between January 2003 and December 2022 of seven online databases (PubMed, Scopus, Embase, Google Scholar, Web of Sciences, Cochrane Library, and China National Knowledge Infrastructure). A systematic literature review and meta-analysis were performed to compare the effects and safety of GKB among T2DM patients. Four groups of parameters were extracted and analyzed: hemorheology parameters, lipid profile, glycemic control markers, and adverse events.ResultsIn the end, 13 eligible articles with 11 indicators among 1573 patients were included. In the hemorheology parameters section, GKB showed significantly lower plasma viscosity (PV) (SMD=-0.91, 95%CI [-1.45, -0.36], P&lt;0.01) and hematocrit (Hct) (SMD=-0.60, 95%CI [-0.97, -0.24], P&lt;0.01) than the control group. GKB shoed higher velocity of the dorsalis pedis artery (VDPA) (SMD=0.51, 95%CI [0.26, 0.76], P&lt;0.01) and ankle brachial index (ABI) (SMD=0.71, 95%CI [0.32, 1.10], P&lt;0.01) than the control. In both the lipid profile and glycemic control markers sections, we did not find any difference between GKB and control groups, including total cholesterol (TC), triglyceride (TG), low-density lipoprotein (LDL), high-density lipoprotein (HDL), hemoglobin A1c (HbA1c), and fasting serum glucose (FSG). In addition, we saw no difference in adverse events (AE). The sensitivity analysis and funnel plot showed that the results in this research were robust and had no publication bias.ConclusionIn conclusion, GKB might safely reduce the risk of peripheral arterial or even systemic cardiovascular disease. However, GKB did not directly improve lipid and blood glucose levels in T2DM patients.Systematic review registrationhttps://inplasy.com/, identifier INPLASY202350096.