bluuebunny/crossref_metadata_2025_split huggingface dataset:
Dietary supplementation with Clostridium butyricum and its ferment substance improves the egg quality and ovarian function in laying hens from 50 to 58 weeks of age
Authors: Wang Yongshuai , Wang Yilu , Wang Leilei , Wei Bin , Lv Xiangyun , Huang Yanqun , Zhang Huaiyong , Chen Wen 
Published: October 2023

AbstractThe current study was conducted to explore the effects of dietary Clostridium butyricum (C. butyricum) and fermented calcium (Ca) butyrate produced by C. butyricum on the performance and egg quality of post‐peak laying. A total of 384 50‐week‐old hens were fed a basal diet, the basal diet with 300 mg/kg of fermented Ca butyrate or 1 × 109 CFU/kg C. butyricum for 8 weeks. Hens received a C. butyricum exhibited higher yolk properties, albumen height, and Haugh unit. A diet with fermented Ca butyrate or C. butyricum increased the egg mass and the pre‐grade yellow follicle number. RNA‐sequencing (RNA‐seq) data showed that these observations were associated with cytokine–cytokine receptor interaction and intestinal immune status. Accordingly, when compared with the basal diet group, Ca butyrate and C. butyricum addition decreased serum pro‐inflammatory cytokine levels and increased the concentration of immunoglobulin A, along with improved intestinal barrier. In addition, dietary C. butyricum inclusion induced a higher abundance of Ruminococcaceae and Lachnospiraceae at the family level. In summary, dietary fermented Ca butyrate or C. butyricum supplementation improved egg quality and ovarian function, which might be related to the enhanced intestinal barrier and immunity in post‐peak laying hens.
Hormonal indexes as predictors of porcine reproductive traits
Authors: Sirotkin Alexander V. , Pivko Juraj 
Published: October 2023

AbstractThe aim of the present study was to examine the applicability of several hormonal indexes for early prediction of puberty and reproductive state in pigs. For this purpose, we have compared the level of hormones leptin, estradiol, progesterone, and IGF‐I in the blood of gilts at 150 days of age and their indexes of puberty and ovarian state at the age of 200 days. The association between blood leptin, estradiol, progesterone, and IGF‐I and indexes of future reproductive state has been demonstrated. High blood concentrations of leptin and IGF‐I levels were associated with relatively low reproductive traits, while high levels of estradiol and progesterone were associated with future high reproductive indexes. These observations are the first demonstration of the applicability of these endocrine indexes for prediction of porcine reproductive traits.
Are emotions essential for consumer ethical decision‐making: A Necessary Condition Analysis
Authors: Escadas Marco , Jalali Marjan S. , Septianto Felix , Farhangmehr Minoo 
Published: October 2023

AbstractThis research examines the necessary condition of emotions in predicting consumer ethical decision‐making, using a new multiplicative method for identifying and measuring the necessary condition in data sets—Necessary Condition Analysis (NCA). Based on a sample of over four hundred individuals, and combining three different consumption scenarios involving ethical issues, our findings demonstrate that emotions are a necessary condition for consumer ethical decisions and behaviours. In addition, the results show that higher levels of consumer ethical decisions can only be achieved if happiness, gladness and satisfaction increase towards a minimum level of necessity. The findings provide empirical support for the essential role of emotions in predicting consumer ethical decision‐making. Furthermore, this research identifies the emotional thresholds without which ethical choices cannot occur and then explains why individuals sometimes behave ethically but other times do not. In addition, this is a first contribution applying NCA to consumer ethics.
Prolonged platelet hyperactivity after COVID‐19 infection
Authors: Nara Noriko , Shimizu Mie , Yamamoto Masahiro , Nakamizo Tomoki , Hayakawa Azusa , Johkura Ken 
Published: October 2023

SummaryPlatelet hyperactivity often occurs in patients with coronavirus disease 2019 (COVID‐19). However, it remains unclear how long platelet hyperactivity lasts after the acute phase, owing to a lack of follow‐up studies. To elucidate the course of platelet hyperactivity, we serially measured platelet activity in patients with COVID‐19 up to 40 days after hospital admission using an easily assessable haematology analyser that semi‐quantitates platelet clumps on a scattergram. Our results showed that platelet hyperactivity persisted for at least 40 days even after acute inflammation subsided in most patients with COVID‐19, regardless of disease severity. Persistent platelet hyperactivity may contribute to thromboembolic complications in post‐COVID‐19 patients.
A solution‐focussed cognitive group intervention for event anxiety in vulnerable children: A randomized controlled trial
Authors: Li Tingting , Lei Junan , Parmak Merle 
Published: October 2023

AbstractVulnerable children have experienced severe life events that may have damaged their self‐esteem and destroyed their inherent potential for survival and development. As a result, they may be more likely to experience psychological problems such as withdrawal, depression, and anxiety. This study aims to combine cognitive behavioural therapy and solution‐focussed brief therapy to develop an effective operational intervention to reduce anxiety related to severe life events in vulnerable children. This intervention contained six stages and a 1 month follow‐up test with 39 vulnerable children (mean age = 8.74, standard deviation = 1.76) randomly assigned to the intervention group (19 participants) and control group (20 participants). The event anxiety and self‐esteem in vulnerable children were assessed by using the Children's Revised Impact of Event Scale, the Spence Children's Anxiety Scale‐Short, and the Rosenberg Self‐Esteem Scale. There was no significant difference between the intervention and control groups in the baseline levels of self‐esteem, event impact, and anxiety. After three intervention phases, the intervention group had a significant increase in self‐esteem and a significant decrease in event anxiety. The changes were stable over time (except for self‐esteem). The results suggest that solution‐focussed cognitive group intervention is an effective method for reducing anxiety related to negative life events in vulnerable children. Furthermore, we have put forth recommendations for future studies that can be utilized to address the limitations identified in this study.
CLDN1 Arg81His founder variant causes ichthyosis, leukocyte vacuoles, alopecia, and sclerosing cholangitis (ILVASC) syndrome in Moroccan Jews
Authors: Eskin‐Schwartz Marina , Dolgin Vadim , Didkovsky Elena , Aminov Ilana , Pikovsky Anna , Hadar Noam , Kristal Eyal , Ling Galina , Cohen Idan , Zilberman Uri , Birk Ohad S. 
Published: October 2023

AbstractNeonatal ichthyosis and sclerosing cholangitis syndrome (NISCH), also known as ichthyosis, leukocyte vacuoles, alopecia, and sclerosing cholangitis (ILVASC), is an extremely rare disease of autosomal recessive inheritance, resulting from loss of function of the tight junction protein claudin‐1. Its clinical presentation is highly variable, and is characterized by liver and ectodermal involvement. Although most ILVASC cases described to date were attributed to homozygous truncating variants in CLDN1, a single missense variant CLDN1 p.Arg81His, associated with isolated skin ichthyosis phenotype, has been recently reported in a family of Moroccan Jewish descent. We now describe seven patients with ILVASC, originating from four non consanguineous families of North African Jewish ancestry (including one previously reported family), harboring CLDN1 p.Arg81His variant, and broaden the phenotypic spectrum attributed to this variant to include teeth, hair, and liver/bile duct involvement, characteristic of ILVASC. Furthermore, we provide additional evidence for pathogenicity of the CLDN1 p.Arg81His variant by transmission electron microscopy of the affected skin, revealing distorted tight junction architecture, and show through haplotype analysis in the vicinity of the CLDN1 gene, that this variant represents a founder variant in Jews of Moroccan descent with an estimated carrier frequency of 1:220.
Exploring factors impacting haplotype‐based noninvasive prenatal diagnosis for single‐gene recessive disorders
Authors: Kong Lingrong , Li Shaojun , Zhao Zhenhua , Feng Jun , Fu Xinyu , Li Huanyun , Zhu Jingqi , Wang Yanan , Tang Weiqin , Yuan Chao , Li Feifei , Han Xiujuan , Wu Di , Kong Xiangdong , Sun Luming 
Published: October 2023

AbstractHaplotype‐based noninvasive prenatal diagnosis (NIPD) is applicable for various recessive single‐gene disorders in proband families. However, a comprehensive exploration of critical factors influencing the assay performance, such as fetal fraction, informative single nucleotide polymorphism (SNP) count, and recombination events, has yet to be performed. It is critical to identify key factors affecting NIPD performance, including its accuracy and success rate, and their impact on clinical diagnostics to guide clinical practice. We conducted a prospective study, recruiting 219 proband families with singleton pregnancies at risk for eight recessive single‐gene disorders (Duchenne muscular dystrophy, spinal muscular atrophy, phenylketonuria, methylmalonic acidemia, hemophilia A, hemophilia B, non‐syndromic hearing loss, and congenital adrenal hyperplasia) at 7–14 weeks of gestation. Haplotype‐based NIPD was performed by evaluating the relative haplotype dosage (RHDO) in maternal circulation, and the results were validated via invasive prenatal diagnosis or newborn follow‐ups. Among the 219 families, the median gestational age at first blood draw was 8+5 weeks. Initial testing succeeded for 190 families and failed for 29 due to low fetal fraction (16), insufficient informative SNPs (9), and homologous recombination near pathogenic variation (4). Among low fetal fraction families, successful testing was achieved for 11 cases after a redraw, while 5 remained inconclusive. Test failures linked to insufficient informative SNPs correlated with linkage disequilibrium near the genes, with F8 and MMUT exhibiting the highest associated failure rates (14.3% and 25%, respectively). Homologous recombination was relatively frequent around the DMD and SMN1 genes (8.8% and 4.8%, respectively) but led to detection failure in only 44.4% (4/9) of such cases. All NIPD results from the 201 successful families were consistent with invasive diagnostic findings or newborn follow‐up. Fetal fraction, informative SNPs count, and homologous recombination are pivotal to NIPD performance. Redrawing blood effectively improves the success rate for low fetal fraction samples. However, informative SNPs count and homologous recombination rates vary significantly across genes, necessitating careful consideration in clinical practice. We have designed an in silico method based on linkage disequilibrium data to predict the number of informative SNPs. This can identify genomic regions where there might be an insufficient number of SNPs, thereby guiding panel design. With these factors properly accounted for, NIPD is highly accurate and reliable.
Understanding patients' perspectives when unprepared for the emergence of a parastomal bulge—a qualitative study
Authors: Krogsgaard Marianne , Dreyer Pia , Thomsen Thordis 
Published: October 2023

AbstractAimThe aim was to investigate patients' experiences of being prepared for the development of a parastomal bulge in relation to a stoma.MethodsThe paper draws on a qualitative interview study conducted with 20 Danish patients participating in five focus groups. Analysis was performed using a phenomenological‐hermeneutic approach.ResultsWe identified three themes. The first theme is ‘The unforeseen bulge gives rise to increasing concern and a search for an explanation’. Patients searched for explanations in their own life and suspected that their behaviour or previous illness induced the bulge. The second theme is ‘Missing or confusing information leads to counterproductive behaviour’. Patients lacked information on the prevention and treatment of parastomal bulging which led to disappointment with healthcare professionals. The third theme is ‘Weighing the pros and cons of life with the bulge against the gamble of surgical repair’. Some patients came to terms with their situation, but for others a deadlocked situation arose when surgical repair was not an option.ConclusionHealthcare communication directly impacts on patients' experiences and outcomes. When unprepared for the emergence of a parastomal bulge, patients' emotional and psychological well‐being are affected and likewise patients' possibility of using their own health beliefs as a preventive strategy. To preserve patient autonomy, satisfaction and well‐being, surgeons and stoma nurses should provide patients with tailored information bearing in mind the current lack of clear evidence on the prevention and treatment of parastomal bulging.
Combining resilience and resistance with threat‐based approaches for prioritizing management actions in sagebrush ecosystems
Authors: Chambers Jeanne C. , Brown Jessi L. , Bradford John B. , Doherty Kevin E. , Crist Michele R. , Schlaepfer Daniel R. , Urza Alexandra K. , Short Karen C. 
Published: October 2023

AbstractThe sagebrush biome is a dryland region in the western United States experiencing rapid transformations to novel ecological states. Threat‐based approaches for managing anthropogenic and ecosystem threats have recently become prominent, but successfully mitigating threats depends on the ecological resilience of ecosystems. We used a spatially explicit approach for prioritizing management actions that combined a threat‐based model with models of resilience to disturbance and resistance to annual grass invasion. The threat‐based model assessed geographic patterns in sagebrush ecological integrity (SEI) to identify core sagebrush, growth opportunity, and other rangeland areas. The resilience and resistance model identified ecologically relevant climate and soil water availability indicators from process‐based ecohydrological models. The SEI areas and resilience and resistance indicators were consistent—the resilience and resistance indicators showed generally positive relationships with the SEI areas. They also were complementary—SEI areas provided information on intact sagebrush areas and threats, while resilience and resistance provided information on responses to disturbances and management actions. The SEI index and resilience and resistance indicators provide the basis for prioritizing conservation and restoration actions and determining appropriate strategies. The difficulty and time required to conserve or restore SEI areas increase as threats increases and resilience and resistance decrease.
MIJ821 (onfasprodil) in healthy volunteers: First‐in‐human, randomized, placebo‐controlled study (single ascending dose and repeated intravenous dose)
Authors: Gomez‐Mancilla Baltazar , Levy Jeffrey A. , Ganesan Subramanian , Faller Thomas , Issachar Gil , Peremen Ziv , Laufer Offir , Shani‐Hershkovich Revital , Biliouris Kostas , Walker Ela , Healy Mark P. , Sverdlov Oleksandr , Desai Sachin , Ghaemi S. Nassir , Cha Jang‐Ho , Shanker Y. Gopi 
Published: October 2023

AbstractThis single‐center study administered MIJ821 (onfasprodil) as an intravenous infusion to healthy volunteers and included two parts: a single ascending dose study (Part 1) and a repeated intravenous dose study (Part 2). Primary objective was to evaluate the safety and tolerability of single ascending intravenous doses infused over a 40‐min period and of two repeated doses (1 week apart) of MIJ821 in healthy volunteers. Secondary objectives were to assess the pharmacokinetics of MIJ821 after intravenous infusion in Part 1 and Part 2 of the study. Overall, 43 subjects in Part 1 and 12 subjects in Part 2 were randomized in the study. Median age in Part 1 and Part 2 was 45.0 and 43.5 years, respectively, with the majority being Caucasian (Part 1: 84%; Part 2: 92%). 19 subjects (44.2%) in Part 1 and 8 subjects (66.7%) in Part 2 experienced at least one adverse event (AE). Following single dose in Part 1 and Part 2, the AUCinf values of MIJ821 increased in a dose‐proportional manner across the dose range 0.016–0.48 mg/kg and the Cmax values in a slight overproportional manner across the dose range 0.048–0.48 mg/kg. At the highest dose of 0.48 mg/kg, the geometric mean AUCinf was 708 h ng/mL and the geometric mean Cmax was 462 ng/mL. Inspection of 1‐h post‐dose resting electroencephalography activity across cohorts showed a relationship to administered dose, providing exploratory evidence of distal target engagement. In conclusion, MIJ821 showed a good safety and tolerability profile in healthy volunteers. Dissociative AEs were mild, transient, and dose‐dependent.
Efficacy of finerenone in patients with type 2 diabetes, chronic kidney disease and altered markers of liver steatosis and fibrosis: A FIDELITY subgroup analysis
Authors: Perakakis Nikolaos , Bornstein Stefan R. , Birkenfeld Andreas L. , Linkermann Andreas , Demir Münevver , Anker Stefan D. , Filippatos Gerasimos , Pitt Bertram , Rossing Peter , Ruilope Luis M. , Kolkhof Peter , Lawatscheck Robert , Scott Charlie , Bakris George L. ,   FIDELIO‐DKD and FIGARO‐DKD investigators
Published: October 2023

AbstractAimInvestigating the effect of finerenone on liver function, cardiovascular and kidney composite outcomes in patients with chronic kidney disease and type 2 diabetes, stratified by their risk of liver steatosis, inflammation and fibrosis.Materials and MethodsPost hoc analysis stratified patients (N = 13 026) by liver fibrosis and enzymes: high risk of steatosis (hepatic steatosis index >36); elevated transaminases [alanine transaminase (ALT) >33 (males) and >25 IU/L (females)]; and fibrosis‐4 (FIB‐4) index scores >3.25, >2.67 and >1.30. Liver enzymes were assessed by changes in ALT, aspartate aminotransferase and gamma‐glutamyl transferase. Composite kidney outcome was defined as onset of kidney failure, sustained estimated glomerular filtration rate decline ≥57% from baseline over ≥4 weeks or kidney death. Composite cardiovascular outcome was defined as cardiovascular death, non‐fatal myocardial infarction, non‐fatal stroke or hospitalization for heart failure.ResultsALT, aspartate aminotransferase and gamma‐glutamyl transferase levels were consistent between treatment groups and remained stable throughout. Finerenone consistently reduced the risk of composite kidney outcome, irrespective of altered liver tests. Higher FIB‐4 score was associated with higher incidence rates of composite cardiovascular outcome. Finerenone reduced the risk of composite cardiovascular outcome versus placebo in FIB‐4 subgroups by 52% (>3.25), 39% (>2.67) and 24% (>1.30) (p values for interaction = .01, .13 and .03, respectively).ConclusionsFinerenone has neutral effects on liver parameters in patients with chronic kidney disease and type 2 diabetes. Finerenone showed robust and consistent kidney benefits in patients with altered liver tests, and profound cardiovascular benefits even in patients with higher FIB‐4 scores who were at high risk of developing cardiovascular complications.
Ultra rapid lispro (Lyumjev®) shortens time to recovery from hyperglycaemia compared to Humalog® in individuals with type 1 diabetes on continuous subcutaneous insulin infusion
Authors: Leohr Jennifer , Dellva Mary Anne , LaBell Elizabeth , Coutant David E. , Arrubla Jorge , Plum‐Mörschel Leona , Zijlstra Eric , Fukuda Tsuyoshi , Hardy Thomas 
Published: October 2023

AbstractAimsTo compare the time to hyperglycaemia recovery after ultra rapid lispro (URLi; Lyumjev®) versus Humalog in a randomized, double‐blind crossover study.Materials and MethodsThirty‐two adults with type 1 diabetes on continuous subcutaneous insulin infusion participated in two periods: each period included hyperglycaemia induced by a missed mealtime bolus (day 1) and by suspension of basal insulin delivery (day 2). When hyperglycaemia [plasma glucose (PG) >240 mg/dl] occurred, a correction bolus of URLi or Humalog was given and time to hyperglycaemia recovery (PG = 140 mg/dl), pharmacokinetics and glucodynamics were compared.ResultsFollowing a missed mealtime bolus, URLi significantly reduced maximum PG (−13 mg/dl; p = .02), and produced numerically more rapid decline in PG (23 mg/dl/h; p = .07), and faster recovery from hyperglycaemia (−23 min; p = .1) versus Humalog, although differences were not significant. Following basal suspension, URLi significantly reduced maximum PG (−6 mg/dl; p = .02), and produced faster PG decline (24 mg/dl/h; p < .001) and faster recovery from hyperglycaemia (−16 min; p < .01) vs. Humalog. Following a correction bolus of URLi, accelerated insulin lispro absorption was observed versus Humalog: early 50% tmax was reduced by 6 or 12 min, and AUC0‐15min was increased 2.5‐ or 4.3‐fold after correction boluses by subcutaneous infusion (day 1) or injection (day 2), respectively (all p < .001).ConclusionsDuring episodes of hyperglycaemia commonly experienced in people with type 1 diabetes, URLi provided a faster recovery versus Humalog from a missed mealtime bolus or during basal insulin suspension. URLi shows significant acceleration of insulin absorption versus Humalog when boluses are administered by subcutaneous infusion or injection.
The self‐perceived impact of sexual abuse on daily life and general health ‐ an issue to consider in dental care
Authors: Wolf Eva , Priebe Gisela 
Published: October 2023

AbstractBackground/AimTo analyse, from the perspective of adults with a history of sexual abuse, the impact of the experience on their general health and well‐being.Material and MethodsThe participants comprised 12 strategically selected informants (10 women), aged 19–56; all sexually abused during child‐ and/or adulthood. They were interviewed in‐depth and encouraged to describe the impact of the sexual abuse on their daily lives. The consequences of sexual abuse on oral health have previously been reported. The interviews were recorded digitally, transcribed verbatim and analysed according to qualitative content analysis with an inductive approach.ResultsThe overall theme illustrating the latent content was Sexual abuse experience—limiting long‐term consequences, always present in body and mind. The first category covering the manifest content was ‘A lost foothold’, with two subcategories: (i) emotional repercussions and (ii) physical health repercussions. The second category was ‘The significance of distance to trauma’, with two subcategories (i) keeping a distance and tending to escape and (ii) processing the trauma experience—a struggle towards balance.ConclusionsA history of sexual abuse cannot be understood in isolation: the long‐term repercussions pervade daily life. However, after disclosure of the abuse and processing the trauma, it is possible to ameliorate some of the negative effects. In this context, the dental setting emerges as a potentially important venue for disclosure as almost every person, sooner or later, visits the dentist.