bluuebunny/crossref_metadata_2025_split huggingface dataset:
Arthralgien bei Psoriasis vulgaris – manchmal lohnt ein zweiter Blick
Authors: Schulte-Terhusen Philipp , Baraliakos Xenofon , Karagkiozidou Dimitra 
Published: January 2024

Zusammenfassung
Anamnese Die 71-jährige Patientin berichtete von langjährig bestehenden entzündlichen Arthralgien bei Psoriasis vulgaris. Eine Therapie mit Methotrexat hatte zu Leberwerterhöhungen geführt, unter Behandlung mit dem TNFα-Inhibitor Adalimumab persistierten die Beschwerden.
Untersuchungen Mittels Arthrosonografie und MRT konnte ein vorwiegend periartikuläres Inflammationsmuster an Handgelenken, Metakarpophalangeal-Gelenken und proximalen Interphalangeal-Gelenken ohne postentzündliche Stigmata einer Psoriasisarthritis objektiviert werden. Laborchemisch fand sich ein erhöhter anti-HCV-Titer mit hoher Viruslast im Sinne einer floriden Hepatitis C.
Diagnose Eine vorwiegend extrahepatisch manifestierte Hepatitis C mit assoziierter Periarthritis wurde diagnostiziert.
Therapie und Verlauf Unter kombinierter, interferonfreier antiviraler Therapie sistierten die Gelenkbeschwerden.
Folgerung Die Hepatitis C kann sich durch extrahepatische Manifestationen im Sinne einer periartikulären Inflammation äußern. Entzündlich suspekte Arthralgien bei Psoriasis vulgaris sind nicht gleichbedeutend mit der Diagnose einer Psoriasisarthritis und sollten fachgerecht rheumatologisch evaluiert werden.
Comparison of the efficacy of HoLEP and TURP in the treatment of elderly benign prostatic hyperplasia patients: a retrospective study
Authors: Aizezi Xierzhati , Feng Liancheng , Wang Zheng , Ma Yuan , Li Jifu , Keremu Abuduweili , Rouzi Maihemujiang , Dilixiati Ailiyaer , Wang Beiping , Shi Hanzhen , Huang Jinxing 
Published: January 2024

Abstract
Objective To prove that holmium laser prostatectomy (HoLEP) is safe and effective in the treatment of benign prostatic hyperplasia (BPH), and is superior to transurethral prostatectomy (TURP) for elderly patients.
Methods We retrospectively studied 565 HoLEP patients and 76 TURP elderly patients. HoLEP patients were first divided into three groups according to their age(Under 65 years old group, 65–79 years old group and over 80 years old group), and their preoperative, intraoperative, and postoperative characteristics were then compared. Secondly, the same characteristics of HoLEP and TURP patients over 80 years were compared. Chi-square test, one-way ANOVA and Fisher’s exact test were used in this study.
Results Firstly, we compared HoLEP patients in different age groups and found that there was statistically significant difference in diabetes, CCVD and bladder stones, among the three groups (P<0.05).Secondlye, we compared HoLEP and TURP treatments in elderly patients (≥80 years old). The patients with HoLEP had a higher share of diabetes, CCVD and anticoagulation (P<0.05). Moreover, compared with TURP patients, HoLEP patients had shorter enucleation duration, more enucleate prostate weight, fewer hemoglobin diminutions, shorter bladder irrigation time, shorter catheter-indwelling period, and shorter hospital period (P<0.05). Although there was no difference in IPSS, Qmax and QOL between the two groups before operation (P>0.05), the difference was statistically significant, 6 months after the operation (P<0.05).
Conclusion HoLEP is safe and effective for BPH patients, and is superior to transurethral TURP for elderly patients.
Augenbeteiligung bei Graft-versus-Host-Erkrankung
Authors: Tappeiner Christoph , Heiligenhaus Arnd , Dietrich-Ntoukas Tina 
Published: January 2024

ZusammenfassungIm Rahmen der okulären Graft-versus-Host-Erkrankung (GVHD) kommt es nach allogener hämatopoetischer Zelltransplantation zu einer Entzündungsreaktion an der Augenoberfläche. Verantwortlich hierfür sind insbesondere selbstreaktive T-Zellen des Spenders. Dies kann u. a. zu einer ausgeprägten Keratoconjunctivitis sicca, Bindehauthyperämie, Hornhautulzerationen und -einschmelzung bis hin zur Perforation führen. Die okuläre GVHD geht mit einem hohen Leidensdruck wie Schmerzen, Photophobie und Visusminderung einher. Diese Übersichtsarbeit gibt einen Überblick über typische ophthalmologische Befunde, topische und systemische Therapieansätze, begleitende Maßnahmen (z. B. Sklerallinsen, Punctum plugs) und das entsprechende Management von Komplikationen.
Effect of Radioiodine Treatment on Quality of Life in Patients with Subclinical Hyperthyroidism: A Prospective Controlled Study
Authors: Larisch Rolf , Midgley John E. M. , Dietrich Johannes W. , Hoermann Rudolf 
Published: January 2024

AbstractRadioiodine treatment (RIT) has a high success rate in both the treatment of hyperthyroidism and improving the quality of life (QoL) of symptomatic patients. In asymptomatic patients with subclinical hyperthyroidism thyroid related QoL outcomes are less well known.
Methods Study aim was to evaluate thyroid-related QoL in patients with subclinical hyperthyroidism mostly due to toxic nodular goitre undergoing RIT, compared to a control group of euthyroid subjects. Study design was monocentric, prospective, controlled. Fifty control subjects were enrolled and 51 RIT patients. Most subjects were examined at least twice at an interval of 6 months, with visits immediately before and 6 months after treatment in the RIT group. QoL was estimated with the ThyPRO questionnaire, using its composite scale as primary outcome. Treatment effect was the mean adjusted difference (MAD) between groups over time, using repeated? measures mixed? effects models.
Results TSH concentrations were lower in the RIT group prior to treatment and recovered thereafter slightly above the level of the control group. Correspondingly, QoL improved significantly after 6 months from a worse level in the RIT group, compared to controls (MAD –10.3 [95% CI –14.9, –5.7], p<0.001). QoL improvements were strong for general items, but less pronounced for the hyperthyroid domain. Compared to controls, thyroid volume, thyroid functional capacity (SPINA-GT) and deiodinase activity (SPINA-GD) were significantly reduced in the RIT group.
Conclusion Patients with subclinical hyperthyroidism improve both biochemically and in their QoL after RIT, compared to controls. QoL assessment should have a wider role in clinical practice to complement biochemical tests and help with treatment decisions.
Same-session endoscopic diagnosis and symptom palliation in pancreato-biliary malignancies: Clinical impact of rapid on-site evaluation (ROSE)
Authors: Vanella Giuseppe , Dell'Anna Giuseppe , Cosenza Agostino , Pedica Federica , Petrone Maria Chiara , Mariani Alberto , Archibugi Livia , Rossi Gemma , Tacelli Matteo , Zaccari Piera , Leone Roberto , Tamburrino Domenico , Belfiori Giulio , Falconi Massimo , Aldrighetti Luca , Reni Michele , Casadei Gardini Andrea , Doglioni Claudio , Capurso Gabriele , Arcidiacono Paolo Giorgio 
Published: January 2024

Abstract
Background and study aims Besides increasing adequacy, rapid on-site evaluation (ROSE) during endoscopic ultrasound (EUS) or endoscopic retrograde cholangiopancreatography (ERCP) may impact choices and timing of subsequent therapeutic procedures, yet has been unexplored.
Patients and methods This was a retrospective evaluation of a prospectively maintained database of a tertiary, academic centre with availability of ROSE and hybrid EUS-ERCP suites. All consecutive patients referred for pathological confirmation of suspected malignancy and jaundice or gastric outlet obstruction (GOO) between Jan-2020 and Sep-2022 were included.
Results Of 541 patients with underlying malignancy, 323 (59.7%) required same-session pathological diagnosis (male: 54.8%; age 70 [interquartile range 63–78]; pancreatic cancer: 76.8%, biliary tract adenocarcinoma 16.1%). ROSE adequacy was 96.6%, higher for EUS versus ERCP. Among 302 patients with jaundice, ERCP-guided stenting was successful in 83.1%, but final drainage was completed in 97.4% thanks to 43 EUS-guided biliary drainage procedures. Twenty-one patients with GOO were treated with 15 EUS-gastroenterostomies and six duodenal stents. All 58 therapeutic EUS procedures occurred after adequate ROSE. With ERCP-guided placement of stents, the use of plastic stents was significantly higher among patients with inadequate ROSE (10/11; 90.9%) versus adequate sampling (14/240; 5.8%) P <0.0001; OR 161; 95%CI 19–1352). Median hospital stay for diagnosis and palliation was 3 days (range, 2–7) and median time to chemotherapy was 33 days (range, 24–47).
Conclusions Nearly two-thirds of oncological candidates for
endoscopic palliation require contemporary pathological diagnosis. ROSE adequacy allows, since
the index procedure, state-of-the-art therapeutics standardly restricted to pathologically
confirmed malignancies (e.g. uncovered SEMS or therapeutic EUS), potentially reducing
hospitalization and time to oncological treatments.
Enhancing Hospitalized Patients' Palliative Care Referrals via Machine Learning-Based Predictive Modeling within Electronic Health Record Systems
Authors: Ghoshal Arun 
Published: January 2024

AbstractAccess to palliative care (PC) holds significance for hospital-admitted patients grappling with the symptoms of life limiting illnesses. Nonetheless, numerous such patients who could gain from PC fail to receive it promptly or even at all.We can leverage the prior year's historical data extracted from electronic health records of hospitalized patients to train a machine learning (ML) model. This model's purpose would be to prognosticate the requirement for PC consultation using real-time data. The model, operating as a semi-supervised system, will be integrated into institutional data pipelines, and utilized by a downstream display application overseen by the PC team. In cases where the PC team deems it suitable, a team member will communicate with the respective care team of the patient. The ML model's training efficacy will be assessed using the area under the curve (AUC) metric, employing a 20% reserved validation set. The threshold for PC consultations will be grounded in historical data. To enhance the ML model's precision, the pivotal variables within the model will be pinpointed, and any sources of biases or errors in the model will be identified for meticulous refinement. The AUC values of successive ML models will be juxtaposed with cross-validation data.Automatizing the referral procedure through electronic health record systems has the potential to usher in a more effective and streamlined approach to healthcare delivery.
Microdissection Testicular Sperm Extraction
Authors: Brant Aaron , Schlegel Peter N. 
Published: January 2024

AbstractNonobstructive azoospermia (NOA) is among the most common causes of male infertility. For men with NOA seeking fertility treatment, microdissection testicular sperm extraction (microTESE) is the best option for retrieving sperm, which can be used with in vitro fertilization–intracytoplasmic sperm injection to achieve pregnancy in their partner. With the aid of the operating microscope, microTESE allows for thorough evaluation of the testis tissue and selection of seminiferous tubules that appear most capable of sperm production. Rates of success with microTESE vary depending on the underlying cause of NOA and the center at which the procedure is performed. Not all patients are candidates for microTESE, and those who are candidates should be counseled on the likelihood of sperm retrieval and the potential for changes in postoperative testis function.
The Association between Sleep and Depression during Late Pregnancy and the Early Postpartum Period
Authors: Jones Angela G. , Hadaie Bachar S. , Bennett Rachel , Kumar Nimisha , Saha Chandan K. , Haas David M. 
Published: January 2024

Abstract
Objective To assess and correlate sleep quality and depressed mood symptoms in the late pregnancy and early postpartum periods.
Study Design In a prospective pilot observational study, participants completed the Pittsburgh Sleep Quality Index (PSQI) and the Edinburgh Postnatal Depression Scale (EPDS) questionnaires at delivery, 1, and 2 months postpartum. Pearson's correlation coefficients and PROC MIXED function estimated overall correlation for repeated measures.
Results Twenty-six women were enrolled with a mean gestational age at delivery of 38.4 (± 2.4) weeks. Sleep quality and mood data were available at the three time points for 24, 16, and 11 participants, respectively. Poor sleep scores were noted by 75.0, 87.5, and 72.7% of women at the three time points. An elevated EPDS score of 10 or higher was claimed by 20.8, 12.5, and 18.2% of women, respectively. Higher PSQI scores were positively associated with higher EPDS scores overall (r = 0.71, p < 0.001) and at each of the individual time points (r = 0.79, p < 0.0001; r = 0.52, p = 0.04; and r = 0.70, p = 0.016, respectively). None of the women reporting good sleep quality had elevated EPDS scores.
Conclusion Poor sleep is commonly reported around delivery, and at 1 and 2 months postpartum, and there is an association between poor sleep and depression symptoms.
Atypical Presentation of Rocky Mountain Spotted Fever in Pregnancy
Authors: Wu Jenny , Dotters-Katz Sarah K. , Varvoutis Megan 
Published: January 2024

AbstractRocky Mountain spotted fever (RMSF) is a common tick-borne disease and can have variable presentation with potentially fatal outcomes when untreated. We describe an atypical presentation of RMSF in the third trimester. A 37-year-old multiparous woman at 310/7 weeks' gestation presented normotensive with headaches and fever but no rash or significant tick exposure. She was initially treated for atypical hemolysis, elevated liver enzymes, and low platelet count syndrome but further decompensated, requiring intensive care unit transfer, intubation, and emergent delivery. Doxycycline administration was associated with marked improvement with no significant sequalae to mother or infant. Later convalescent serologies were positive for RMSF. RMSF is a clinically challenging diagnosis in pregnancy. Given significant morbidity and mortality associated with delayed treatment, high suspicion in endemic areas is needed, and prompt antibiotic use with doxycycline should be administered.
Microenvironment of the Lower Reproductive Tract: Focus on the Cervical Mucus Plug
Authors: Ruiz-Durán Susana , Tenorio Celia M. , Vico-Zúñiga Irene , Manzanares Sebastián , Puertas-Prieto Alberto , Altmäe Signe , Vargas Eva 
Published: January 2024

AbstractThe female lower reproductive tract microbiota is a complex ecosystem comprising various microorganisms that play a pivotal role in maintaining women's reproductive well-being. During pregnancy, the vaginal microbiota undergoes dynamic changes that are important for a successful gestation. This review summarizes the implications of the cervical mucus plug microenvironment and its profound impact on reproductive health. Further, the symbiotic relationship between the vaginal microbiome and the cervical mucus plug is highlighted, with a special emphasis on how this natural barrier serves as a guardian against ascending infections. Understanding this complex host–microbes interplay could pave the way for innovative approaches to improve women's reproductive health and fertility.
Effect of Head Position on Distortion Product Otoacoustic Emissions
Authors: Ponnana SA Pancham , Winston Jim Saroj 
Published: January 2024

Abstract
Objectives The study aimed to explore the impact of various head positions on the distortion product otoacoustic emissions (DPOAE) amplitudes, identifying the specific DPOAE frequencies showing the effect was also of interest.
Materials and Methods DPOAEs were recorded from the right ears of 50 normal-hearing individuals in six head positions, supine, and five sitting positions (head erect, roll left, roll right, pitch backward, and pitch forward). DPOAEs were averaged and measured for their overall and frequency-specific amplitudes at 1 kHz, 1.5 kHz, 2 kHz, 3 kHz, 4 kHz, 6 kHz, and 8 kHz.
Statistical Analysis To investigate the statistical significance of the observed mean differences, the data was tested using repeated measures of analysis of variance (ANOVA) following the Shapiro–Wilk normality test. The pair-wise comparison was tested using the Bonferroni post-hoc test and one-sided Bayesian paired sample t-test.
Results The results of ANOVA revealed a significant main effect of head posture only at 1 kHz. The Bonferroni post-hoc test and one-sided Bayesian paired sample t-test results showed significantly higher DPOAE amplitude in the head erect compared to the supine position. There were no significant differences between other pairs of head postures.
Conclusion Head posture is a trivial influencing factor of DPOAEs and hence, does not require consideration in interpreting DPOAEs.
An Interesting Case of Penetrating Brain Injury Due to Assault with Meat Chopper Knife
Authors: Ojha Bal Krishna , Zeeshan Qazi , Miglani Rahul 
Published: January 2024

AbstractPenetrating injuries to brain are rare and mostly result from warfare injuries, suicidal/homicidal firearm injuries, or accidental injuries. In general, they are associated with poor outcome. We report the challenges faced in managing an interesting case of penetrating brain injury as a result of assault with meat chopper knife that underwent surgical intervention and had a good outcome.
Ureteroinguinal Herniation with Consecutive Ureteral Stricture in a 2-Month-Old Infant: Case Report
Authors: Delgado-Miguel Carlos , Muñoz-Serrano Antonio Jesus , Aguado Pablo , Fuentes Ennio , Díez Ricardo 
Published: January 2024

AbstractInguinal herniation of ureter is an uncommon finding among children, with scarce reported cases in the literature to date, that can potentially lead to obstructive uropathy. We report a case of ureteroinguinal herniation discovered during an inguinal hernia repair in a patient with antenatally ultrasound finding of hydronephrosis. A 2-month-old infant with antenatal left hydronephrosis presented with left inguinal mass. Preoperative ultrasound showed an anechoic tubular image producing a mass effect on the left testicle, with suspected bladder herniation and/or dilated ureter toward the inguinal canal. An open surgical inguinal exploration was performed, where the left inguinal canal revealed a peritoneal sac and sliding of the dilated left ureter behind the sac, with a significant change in diameter, corresponding to the paraperitoneal variant of ureteroinguinal herniation. Ligation of the sac and replacement of the ureter into the retroperitoneum were performed, with improvement in the hydronephrosis observed on the ultrasound 1 month after the intervention. However, 6 months later, hydronephrosis worsening as well as the obstructive pattern observed in the diuretic renogram required removal of the stenotic ureteral segment and reimplantation of the healthy proximal segment in the bladder by open approach (Cohen's reimplantation). Follow-up ultrasound of the renal tract showed no dilatation of the upper renal tract and the renal function tests were normal. Currently, the patient is 2 years old and he remains asymptomatic. In conclusion, signs of ureteral obstruction such as hydronephrosis in patients with inguinal herniation may suggest the possibility of an ureteroinguinal hernia. Preoperative diagnostic suspicion is essential.
Hybrid finite-volume–finite-element scheme for 3D simulation of thermal plasma arc configuration
Authors: Komaizi D. , Niknam A. R. 
Published: January 2024

The plasma dynamics in a three-dimensional free-burning arc configuration are studied using an iterative hybrid finite-volume–finite-element scheme. In this scheme, Navier–Stokes equations are solved with a classical finite volume approach. It is a conservative method that is suitable for solving conservation equations. In addition, a nodal finite element analysis is used to solve Maxwell’s equations for the scalar and vector potentials. The finite-volume and finite-element modules are verified against well-known simple problems. The plasma is considered an incompressible fluid in chemical and thermal equilibrium or local thermodynamic equilibrium. The profiles of fluid and electromagnetic characteristics are depicted for a total current equal to 200 A. The results of this simulation method are in agreement with experimental and numerical predictions.
Experimental studies and COMSOL 1-D simulation in Ar capacitively coupled plasmas
Authors: Datta Salini , Han Jeon G. , Kumar R. , Sahu Bibhuti B. 
Published: January 2024

This work systematically studies a capacitively coupled plasma (CCP) source using experiments and 1-D COMSOL simulations relevant to Ar plasmas. Two radio frequency compensated Langmuir probes (LPs) and optical emission spectroscopy (OES) were purposefully used to measure the plasma parameters, and the experimental results were compared with those of simulations. We studied the axial variation of plasma parameters using an axial LP between the power and ground electrodes of the CCP at various operating pressures ranging from 10 to 150 mTorr. The electron density showed a gradual increase in its value with rising pressures. In addition, we employed a radial LP at the axial location L = 4 cm from the surface of the power electrode to measure the plasma parameters and compare these data with those of the axial LP and simulations. The variations of plasma potential measured by the radial LP showed an opposite trend of variation to those of simulations and the axial LP at pressures 10–60 mTorr, which is attributed to the plasma diffusion at low pressures. LP and OES measurements and simulation data suggest stochastic heating that generates high electron temperatures at low pressures. In addition, data revealed that the high-density plasma generation at high pressures could be due to the effects of both collisional heating and stochastic heating. Analysis showed that electrons could gain energy from the strong field regime of the sheath closed to the electrodes, which has a similar variation to electron temperature. The results of simulations have shown excellent agreement with experiments, and this work has the basis for plasma applications like plasma-enhanced chemical vapor deposition.
Switchable and high-efficiency phase-locking of S-band magnetrons with coaxial line
Authors: Wang L. C. , Yin Y. , Qin Y. , Hou W. S. , Bi L. J. , Li H. L. , Wang B. , Meng L. 
Published: January 2024

We propose a coaxial line structure for phase-locking between magnetrons in the S-band for the first time. In this structure, two magnetrons operating in the π-mode are tightly coupled by the coaxial line. The design of a coaxial line structure, independent of physical dimensions, solves the problem of a ridge waveguide or rectangular waveguide being unsuitable for phase-locking in the compact S-band magnetron, as proposed by previous researchers. In addition, the phase relationship of the magnetron output signal in the phase-locked state can be switched between 0 and the π phase difference without changing the length of the coaxial line. Therefore, this design widens the frequency range used by mutual coupling phase-locked technology and allows switching of the phase relationship in an output signal without the need for additional equipment or physical space. After design simulation, two magnetrons achieved high-efficiency phase locking at a frequency of 2.415 GHz, with a phase-locked efficiency of 99.8%.