bluuebunny/crossref_metadata_2025_split huggingface dataset:
Imaging characteristics relevant to pulmonary perfusion improvement after balloon pulmonary angioplasty in chronic thromboembolic pulmonary hypertension
Authors: Yao Dandan , Wu Jiaoyan , gong juanni , yang yuanhua , wang jianfeng , Yang Min-Fu 
Published: November 2023

Abstract
Purpose
Balloon pulmonary angioplasty (BPA) has been proven to be an effective alternative treatment for inoperable chronic thromboembolic pulmonary hypertension (CTEPH). However, the segmental lung perfusion (LP) improvement after BPA may be inapparent. Therefore, this study aimed to explore the characteristics of BPA-targeted vessels related to segmental perfusion improvement after BPA.
Methods
Twenty-seven patients with CTEPH who underwent ≥ 4 BPA sessions and had both pre- and post-BPA LP single-photon emission computed tomography (SPECT) were retrospectively analyzed. The baseline perfusion defect score (PDs), location, and angiographic characteristics of BPA-targeted vessels were collected to evaluate their correlations with the efficacy of BPA assessed by LP-SPECT.
Results
The percentage of overall PDs improvement correlated with the percentage of mean pulmonary artery pressure (mPAP) improvement after BPA (r values of 0.479, P = 0.012). Lesions in the upper lobe had the lowest perfusion improvement rate (upper lobe vs middle or lingual lobe, P < 0.001; upper lobe vs lower lobe, P < 0.001). Moreover, lesions with baseline PDs ≥ 0.5 had a lower perfusion improvement rate than those with PDs < 0.5 (all P < 0.05). Nevertheless, angiographic characteristics of target vessels had no association with the perfusion improvement rate. Based on these results, a 3-point scale was constructed for predicting segmental perfusion improvement after BPA. The perfusion improvement rates of vessels with scores of 0, 1, and 2 were 76.5%, 62.3%, and 8.3%, respectively (all P < 0.05).
Conclusions
This study demonstrates that LP-SPECT can effectively evaluate the efficacy of BPA in patients with CTEPH. Lesions located in the upper lobe with mild perfusion injury are unsuitable for BPA.
Predictive value of ultrasound classification for autologous arteriovenous fistula stenosis in short-term efficacy of ultrasound- guided percutaneous transluminal angioplasty
Authors: Lin Jie , Chen Li , Ding Hong , Wang Yong , Lv Renhua , Huang Zhifang , Tan Jinyun , He Qing 
Published: November 2023

Abstract

To analyze the efficacy of percutaneous transluminal angioplasty (PTA) with ultrasound for different types of arteriovenous fistula (AVF) stenosis. Methods: Clinical data of 51 ESRD patients admitted to the Hemodialysis Center of Huashan Hospital for PTA due to AVF stenosis from January 2018 to May 2020 were analyzed retrospectively. According to the location and etiology of stenosis, AVF stenosis were divided into type I to III and type A to C. The postoperative stenosis recovery, flow improvement, technical success rate and short-term restenosis rate of different types after treatment were observed. Results: The success rate of PTA was 96.2%, and the 9 cases relapsed within 6 months. After operation, the flow volume was significantly increased(P<0.005), in which the type A and C were more markedly than type B (P<0. 05). Two cases without technical success were type AII, and the main short-term relapse stenosis were related to intimal hyperplasia. Conclusion: PTA is an effective treatment for AVF stenosis. The drainage vein was the predilection site of stenosis. The postoperative flow volume of type A and C were not as high as that of type B, while the type with intimal hyperplasia was easy to relapse, and open surgery might be considered if necessary.
Exploring the barriers and enablers of the self-management ability in colorectal cancer patients with enterostomy: a qualitative study based on social ecological model
Authors: WANG WENTING , XU MENGYA , XING ZHAOWEI , LU FEI , ALISWAG EMERSON GALANG , WU JIANGHUA 
Published: November 2023

Abstract
Background:Since enterostomy surgery changes the way a patient defecates, it is essential for the patient to be self-managing in order to adapt to this change.
Objective:We aimed to explore the barriers and enablers affecting the self-management ability of colorectal cancer patients with enterostomy from the perspectives of social ecological model, to provide insight for developing self-management intervention programs to better meet the needs of patients.
Methods:An exploratory qualitative study guided by social ecological model and followed the Consolidated Criteria for Reporting Qualitative Research (COREQ) guidelines was conducted . A total of 11 colorectal cancer patients with enterostomy from in the gastrointestinal surgery ward and ostomy clinic of a Grade A tertiary hospital in Shandong Province from January 2023 to April 2023 were recruited, and semi-structured in-depth interviews were used to collect data. Colaizzi data analysis and Nvivo 11.0 software were used to analyze the interview data.
Results:Facilitators relating to self-management ability included perceived benefits of self-management, acquisition of enterostomy knowledge and skills, positive psychological adjustment, family responsibility drive, and improvement of the health care system. Barriers included lack of ostomy knowledge and skills, adverse experience of the disease, family barriers, social negative environmental influences, limited access to medical care, and barriers to information access.
Conclusion:This study indicated that factors from the aspects of microsystem(e.g.,lack of ostomy knowledge and skills, adverse experience of the disease), mesosystem(e.g.,family barriers, social negative environmental influences), macrosystem(e.g.,limited access to medical care, and barriers to information access) would potentially affect the self-management ability of the colorectal cancer patients with enterostomy, interventions taget n these aspects might improve patients' self-management ability.
Isolated Overburden Grout Injection Technology Mining and Grouting Parameters Discussion and Redesign
Authors: LI Ya-xing , MA Jun , YANG Ke-ming , JIANG Ke-gui , GU Xin-ru , PENG Li-shun , CHEN Xin-yang 
Published: November 2023

Abstract
The "Three down" coal resource mining, ground subsidence management, and fly ash waste treatment are carried out using the Isolated Overburden Grout Injection Technology, which embodies the idea of green mining. The concurrent mining and grouting of bed-separation voids beneath key strata are intricately intertwined and subject to space and time constraints. Isolated Overburden Grout Injection Technology may be successfully analyzed using the large-deflection inclined thin plate mixed with the slurry model. Nevertheless, the diversity in stratigraphic parameters, including main roof and principal key strata (PKS), across various mines, as well as variations in design parameters such as working face dimensions, mining height, coal seam angle of inclination, mining speed, and grouting parameters like the number of grouting holes, start and finish times, and slurry consistency, ultimately contribute to discrepancies in outcomes such as PKS deflection and Bed-separation development, as well as the maximum subsidence and extent of the ground subsidence basin. To ensure the precise and efficient protection of village structures, the extraction of coal resources, and the proper disposal of fly ash waste, it is imperative to conduct a comprehensive analysis of the impact of each parameter of the model. This analysis will help elucidate the mining and grouting process and facilitate the rational design of the relevant parameters. This paper categorizes and discusses the impact of each parameter on the outcomes, using the case study of the 7221 work face grouting operations in Huaibei, Anhui Province, China. In order to fulfill the protection needs of the Gaochangying and Houlou Gaojia villages, modifications were made to the mining and grouting sections' parameters. These modifications evaluated the potential benefits of increasing the original design of coal seam resources and implementing fly ash backfill.
Comparative analysis of three types of EMAT detection performance in high-temperature aluminum alloy laser electromagnetic ultrasound
Authors: Xu Zisheng , Shi Wenze , Lu Chao , Hu Bo , Qiu Fasheng , Liu Yuan 
Published: November 2023

Abstract
Currently there are three forms of probe configurations for laser electromagnetic ultrasonic inspection of high-temperature aluminum alloys. They are Meander line coil (MLC) electromagnetic ultrasonic transducer (EMAT), in-plane EMAT, and out-of-plane EMAT. However, there are challenges, such as poor signal-to-noise ratio of echo signal and unclear application occasions of the three types of Laser-EMAT in the process of high-temperature detection. Therefore, a finite element model of multi-physical field coupling analysis of high-temperature aluminum alloy laser electromagnetic ultrasonic detection process was established. Subsequently, the influence of temperature on the reception efficiency of the three types of EMAT was analyzed, and the capability of the three types of EMAT for the detection of surface defects was explored. By conducting surface wave detection studies of the three types of EMAT for Laser-EMAT of aluminum alloy plates at high temperatures, the applications of the three types of EMAT were determined. The results established that the out-of-plane EMAT has the best reception performance, and the received surface wave signal has the highest amplitude, the best resolution. Then the out-of-plane EMAT was designed to optimize parameters such as the permanent magnet height and width, coil width, coil-wire diameter, and coil pitch. Finally, high-temperature aluminum alloy crack detection was carried out, and the experiments established that the out-of-plane EMAT can receive a defect wave of 86 mV at 500 ℃.
Ferroptosis typing of osteosarcoma and the screening and verification of its markers
Authors: Li Yankun , Li Xian , Liu Qi , Li Bo , Sun Li , Luo Rui , Yuan Fei , Ye Chuan , Li Guoming , Zhao Quanming 
Published: November 2023

Abstract
Osteosarcoma (OS) is an aggressive cancer characterized by a poor prognosis.It primarily affects young individuals and has a survival rate of less than five years.Lately, there has been an increasing fascination with the involvement of ferroptosis, a cell death pathway that relies on iron, in cancer stem cells(CSCs) and its potential as a focus for enhancing the effectiveness of cancer treatment.Nonetheless, the role of the iron death pathway in OS is still unclear. In our investigation, we employed WGCNA and PPI network analysis to discover pivotal hub genes (YRDC,ARPC5,EIF2S1, CAPZA1).Subsequently, we examined the correlation between the expression of these genes in protein samples from tissue chips and the clinical information of osteosarcoma using immunohistochemistry.In addition, we confirmed the levels of YRDC, ARPC5, EIF2S1, and CAPZA1 expression in OS and healthy osteoblasts through rt-PCR and Western Blot methods.In order to assess the influence of these four genes on the growth and ability to form colonies of cells, we performed MTT and clonogenic tests. Our findings strongly indicate a notable correlation between the levels of protein expression of YRDC, ARPC5, EIF2S1, and CAPZA1 and the Enneking stage of OS, along with the occurrence of lymph node metastasis.Furthermore, these proteins showed a direct association with the growth and ability of OS cells to form colonies.To summarize, the genes YRDC, ARPC5, EIF2S1, and CAPZA1 show potential as diagnostic indicators and targets for treatment in the iron death pathway of osteosarcoma.
Single Emitter Localization
Authors: Bhattacharyya Tamoghna 
Published: November 2023

Abstract
Understanding the relationships between molecular organization and dynamics of a complex system is very important to understand the photophysical properties of such system. This paper focuses on a novel strategy based on single molecule spectroscopy and single molecule localization microscopy to elucidate the organization, photostability and localization of a single molecule on a 2D biomembrane. Improvement of in-plane resolution of a signal in a nano-dimension within the diffraction limit has been discussed in a new way. And, how this better in-plane resolution information can be used for precise localization of a single molecule on a 2D system has also been discussed.
RAS mutation nomograms to predict prognosis after radiofrequency ablation of recurrent colorectal liver metastases
Authors: Wang Ji-Chen , Jiang Bin-Bin , Zhang Zhong-Yi , Liu Yu-Hui , Shao Li-Jin , Wang Song , Yang Wei , Wu Wei , Kun Yan 
Published: November 2023

Abstract
Objectives: This study was conducted to develop nomograms for predicting repeat intrahepatic recurrence (rIHR) and overall survival (OS) after radiofrequency ablation (RFA) treatment in patients with recurrent colorectal liver metastases (CLMs) after hepatectomy based on RAS mutation and clinicopathologic features.
Methods: A total of 160 consecutive patients with recurrent CLMs after hepatectomy who were treated with ultrasound-guided percutaneous RFA from 2012 to 2022 were retrospectively included. Potential prognostic factors associated with rIHR and OS after RFA, identified by the competing-risks model and Cox proportional hazard model, respectively, were used to construct nomograms. The performance of each nomogram was evaluated by Harrell’s C-index and calibration curve with bootstrapping.
Results: The 1-, 2-, and 3-year rIHR rates after RFA were 59%, 69%, and 74%, respectively. The 1-, 3- and 5-year OS rates were 96.2%, 66.7%, and 47.0%, respectively. Four predictive factors, RAS mutation, interval from hepatectomy to intrahepatic recurrence, carcinoembryonic antigen (CEA) level at ablation, and ablation margin, were incorporated in the rIHR nomogram with a C-index of 0.694. Five predictive factors, RAS mutation, largest CLM at hepatectomy, CEA level at ablation, extrahepatic disease, and ablation margin, were incorporated intothe OS nomogram with a C-index of 0.743. The calibration curves presented good agreement between thenomograms and actual observations.
Conclusions: The established nomograms can predict the individual risk of rIHR and OS after RFA for recurrent CLMs and contribute to better individualized management.
Advances in knowledge: This study highlights the predictive value of RAS mutation for rIHR and OS after RFA of recurrent CLMs.
Machine learning radiomics models based on B-mode and contrast-enhanced ultrasound for assisted diagnosis of benign and malignant thyroid nodules: A prospective study
Authors: Zhang Qian , Chen Jiahui , Gao Xuemeng , Zhu Tiantong , Zhao Aoxue , Huang Ying 
Published: November 2023

Abstract
Objectives To develop a radiomics model for differential diagnosis of thyroid nodules based on B-mode ultrasound and contrast-enhanced ultrasound images. To determine if the diagnostic efficiency of radiologists is improved by the use of this radiomics model.
Methods In this prospective single-center study, from October 2021 through January 2023, patients scheduled for thyroidectomy or fine-needle aspiration cytology have been preoperatively examined using a standardized B-mode ultrasound combined with contrast-enhanced ultrasound examination. Radiomics models were developed based on B-mode and contrast-enhanced ultrasound images. Two rounds of reader studies were performed to verify the clinical application value of the model.
Results A total of 404 patients were enrolled, and the 412 nodules were split into training and test sets. The AUCs in differential diagnosis of thyroid nodules were 0.799 for the B-US radiomics model, 0.766 for the CEUS radiomics model, and 0.890 for the B-US+CEUS radiomics model. The sensitivity of the B-US+CEUS radiomics model in diagnosis was higher than that of the three radiologists, and the accuracy of the model was higher than the diagnoses of the intermediate and junior radiologists. The diagnostic sensitivity of all radiologists was further improved with the aid of the B-US+CEUS radiomics model.
Conclusion The findings of this study suggest that both B-mode ultrasound and contrast-enhanced ultrasound radiomics features offer a high clinical value. Using them in combination leads to improved diagnostic performance. Our B-US+CEUS radiomics model is an effective tool to assist radiologists in differential diagnosis of thyroid nodules.
Risk for waterborne transmission and environmental persistence of avian influenza virus in a wildlife/domestic interface in Mexico
Authors: Mateus-Anzola Jessica , Gaytán-Cruz Liliana , Espinosa-García Ana Cecilia , Martínez-López Beatriz , Ojeda-Flores Rafael 
Published: November 2023

Abstract

Aquatic habitats provide a bridge for influenza transmission among wild and domestic species. However, water sources pose highly variable physicochemical and ecological characteristics that affect avian influenza virus (AIV) stability. Therefore, the risk of survival or transmissibility of AIV in the environment is quite variable and has been understudied. In this study, we determine the risk of waterborne transmission and environmental persistence of AIV in a wild/domestic bird interface in the Central Mexico plateau (North America) during the winter season using a multi-criteria decision analysis (MCDA). A total of 13 eco-epidemiological factors were selected from public-access databases to develop the risk assessment. The MDCA showed that the Atarasquillo wetland presents a higher persistence risk in January. Likewise, most of the poultry farms at this wild-domestic interface present a high persistence risk (50%). Our results suggest that drinking water may represent a more enabling environment for AIV persistence in contrast with wastewater. Moreover, almost all poultry farms evidence a moderate or high risk of waterborne transmission especially farms close to water bodies. The wildlife/domestic bird interface on the Atarasquillo wetland holds eco-epidemiological factors such as the presence of farms in flood-prone areas, the poultry access to outdoor water, and the use of drinking-water troughs among multiple animal species that may enhance waterborne transmission of AIV. These findings highlight the relevance of understanding the influence of multiple factors on AIV ecology for early intervention and long-term control strategies.
Measuring the Kapitza Resistance between a Passivated Semiconductor and Liquid Helium
Authors: Mohammadian Babak , McCulloch Mark , Gilles Valerio , Sweetnam Thomas , Piccirillo Lucio 
Published: November 2023

Abstract
In this paper, we describe an experimental investigation into the effect of passivation layer thickness on heat dissipation between a quartz substrate and liquid helium. We have observed that by depositing SiN from 0 to 240 nm, the Kapitza resistance increases by ∼ 0.0365 m2.K/W per nanometer more than for unpassivated semiconductor. We hypothesize that this increase in Kapitza resistance represents an additional barrier to the cooling of semiconductor devices in liquid helium.
Biotransformation of docosahexaenoic acid into 10R,17S- dihydroxydocosahexaenoic acid as protectin Dx 10-epimer by serial reactions of arachidonate 8R- and 15S-lipoxygenases
Authors: Lee Tae-Eui , Ko Yoon-Joo , Shin Kyung-Chul , Oh Deok-Kun 
Published: November 2023

Abstract

Protectins, 10,17-dihydroxydocosahexaenoic acids (10,17-DiHDHAs), are belonged to specialized pro-resolving mediators (SPMs). Protectins are generated by polymorphonuclear leukocytes in humans and resolve inflammation and infection in trace amounts. However, the quantitative production of protectin Dx 10-epimer (10-epi PDX, 10R,17S-4Z,7Z,11E,13Z,15E,19Z-DiHDHA) has been not attempted to date. In this study, 10-epi PDX was quantitatively produced from docosahexaenoic acid (DHA) by serial whole-cell biotransformation of Escherichia coli expressing arachidonate (ARA) 8R-lipoxygenase (8R-LOX) from the coral Plexaura homomalla and E. coli expressing ARA 15S-LOX from the bacterium Archangium violaceum. The optimal bioconversion conditions to produce 10R-hydroxydocosahexaenoic acid (10R-HDHA) and 10-epi PDX were pH 8.0, 30°C, 2.0 mM DHA, and 4.0 g/L cells; and pH 8.5, 20°C, 1.4 mM 10R-HDHA, and 1.0 g/L cells, respectively. Under these optimized conditions, 2.0 mM (657 mg/L) DHA was converted into 1.2 mM (433 mg/L) 10-epi PDX via 1.4 mM (482 mg/L) 10R-HDHA by the serial whole-cell biotransformation within 90 min, with a molar conversion of 60% and volumetric productivity of 0.8 mM/h (288 mg/L/h). To the best of our knowledge, this is the first quantitative production of 10-epi PDX. Our results contribute to the efficient biocatalytic synthesis of SPMs.
Occupational exposure to heavy metals (Cd, Co, Zn) associated with DNA oxidative stress: a cross-sectional study among urban green space workers; Tehran, Iran
Authors: Jalaldehi Pourya Ahmadi , Abbaslou Hossein , Shahtaheri Seyed Jamaleddin , Malekshahi Ziba Veisi , Derav Nasim Farahmand , Azam Kamal , Khadem Monireh 
Published: November 2023

Abstract
heavy metals impact the urban population, the environment, and workers exposed to these pollutants. Green space workers during the day shift and peak city traffic hours have constant exposure to air pollutants. This study aimed to determine the concentration of heavy metals including, Cd, Co, and Zn in urine and breathing air samples among green space workers of Tehran Municipality and investigate the associations between heavy metal exposure and DNA oxidative stress. In addition, a comparative analysis was conducted between green space workers and office employees (as the control group). NIOSH-7300 and NIOSH-8310 were used to collect and prepare air and urine samples. The final sample concentration was measured by ICP-OES. Furthermore, two 96-test ZellBio GmbH kits assessed urinary 8-OHDG, a biomarker of DNA oxidative stress. The mean concentration of urinary and air heavy metals and urinary 8-OHDG exhibited a statistically significant increase in the exposed group compared to the control group (except for Cd in the air). Moreover, the Pearson correlation coefficient (R) between urinary heavy metals and 8-OHDG values in the exposed group revealed that there are significant relations between urinary Cd, Co, and Zn with 8-OHDG: R = 0.734, R = 0.836, and R = 0.584 respectively (P˂0.001). No correlations were observed between heavy metals and 8-OHDG in the control group. Findings revealed that cobalt and cadmium exhibit the most significant influence on changes in oxidative stress, as indicated by the dependent variable 8-OHDG. This study showed a strong association between exposure to heavy metals and 8-OHDG levels in workers with low airborne metal exposure, however, future studies should also recognize the indisputable role of heavy metals in oxidative stress and examine other factors like diet, lifestyle, habits (smoking and exercising), and other pollutants in affected workers' environment.