bluuebunny/crossref_metadata_2025_split huggingface dataset:
The effect of baseline versus early glucocorticoid use on immune checkpoint inhibitor efficacy in patients with advanced NSCLC
Authors: Wang Yifan , Zhou Jianying , Peng Simin , Cui Zhao , Wang Weiqi , Zeng Wenqin , Qiu Tingting , Liu Zhentian 
Published: January 2025

PurposeThis study aims to investigate the specific effects of glucocorticoids (GC) on the efficacy of immune checkpoint inhibitors (ICIs), and whether this effect is influenced by the timing and dosage of GC administration. Changes in the neutrophil percentage and the helper/suppressor T lymphocyte ratio [NEUT %/(CD4+/CD8+)] during GC administration were monitored.MethodsThe clinical results of 130 patients with advanced non-small cell lung cancer (NSCLC) treated with ICIs were analyzed and compared with those of patients who did not use GC. Cox proportional hazards regression model and Logistic regression analysis were used to analyze the factors affecting ORR and PFS, and t test was used to analyze the changes of NEUT %/(CD4 +/CD8 +) during GC use.ResultsMultivariate Logistic analysis showed that GC use was associated with a higher ORR in 130 patients treated with ICIs [HR = 3.07,95% CI (1.31-7.21), P = 0.010]. Univariate Cox analysis showed that GC use was not significantly correlated with PFS [HR = 0.926,95% CI (0.603-1.420), P = 0.710]. Patients who used GC during the baseline period of ICIs treatment had a higher ORR than those who used GC at the early stage of ICIs treatment (65.4% vs 30.8%, p = 0.024). Multivariate Cox analysis showed that GC use had longer PFS [HR = 0.37,95% CI (0.17-0.78), p = 0.009]. The timing of GC use was different, and there was a difference in NEUT %/(CD4 +/CD8 +) levels before and after treatment. There was no significant difference in ORR and PFS between GC duration and dose.ConclusionThe use of GC helps to enhance the efficacy of immunotherapy. In particular, GC use during the baseline period leads to higher ORR and PFS, regardless of the dose or duration of GC use. The levels of NEUT %/(CD4+/CD8+) varied depending on the timing of GC administration.
Prevalence and determinants of post-neonatal mortality in East Africa: a multilevel analysis of the recent demographic and health survey
Authors: Zegeye Alebachew Ferede , Asmamaw Desale Bihonegn , Negash Wubshet D. , Belachew Tadele Biresaw , Fentie Elsa Awoke , Kidie Atitegeb Abera , Baykeda Tsegaw Amare , Fetene Samrawit Mihret , Addis Banchlay , Maru Wubante Sisay , Endawkie Abel , Tamir Tadesse Tarik 
Published: January 2025

BackgroundOne of the most common measures of society's health is mortality among neonates. Developing and developed countries still differ significantly in neonatal mortality rates. While there are about 18 neonatal deaths worldwide for every 1,000 live births during the first month of life, less is known about neonatal mortality in developing countries, especially in East Africa. Understanding the extent of mortality during the post-neonatal period and its determinants is crucial for developing appropriate policies and strategies that could help solve the issue. Thus, the aim of this study was to identify the prevalence of post-neonatal mortality in East African countries and the factors that are associated with it.MethodsSecondary data analysis was conducted using data from the most recent Demographic and Health Surveys, which included 11 East African countries between 2014 and 2022. A weighted sample of 225,635 live births had been used in the study. STATA/SE 14 was used for data analysis. The multilevel mixed-effects logistic regression model was applied to determine the factors associated with post-neonatal mortality. In the multilevel logistic regression model, significant factors were deemed to be associated with post-neonatal mortality at p-values &lt;0.05. The data were interpreted using the adjusted odds ratio (AOR) and confidence interval (CI). The best-fit model has been found to be the one with the lowest deviance and highest logliklihood ratio.ResultsIn East Africa, post-neonatal mortality was found to be 15 per 1,000 live births. Pregnancy type (AOR = 3.09, 95% CI: 2.30, 4.13), birth weight (AOR = 1.58, 95% CI: 1.25, 2.01), maternal age (AOR = 1.58, 95% CI: 1.32, 1.90), maternal education (AOR = 1.82, 95% CI: 1.14, 2.92), tetanus shots prior to delivery (AOR = 1.23; 95% CI: 1.06–1.42), birth order (AOR = 5.68, 95% CI: 4.48, 7.24), those born in Uganda (AOR = 1.33, 95% CI: 1.03, 1.73), and Burundi (AOR = 1.48, 95% CI: 1.11, 1.98) had the highest odds of post-neonatal death.ConclusionAccording to this study, post-neonatal mortality is higher in developing countries, particularly in East Africa. It was discovered that factors at the individual and community levels associated with post-neonatal mortality. Consequently, focus should be paid to babies born to mothers in the lowest age group, those born of multiple pregnancies, without formal educations, who did not receive tetanus shots prior to birth, and who were born in the first birth order.
The influence of different negative feedback on the decay of self-deception
Authors: Liu Juan , Ding Wenjun , Deng Liying , Tan Min , Guan Peipei 
Published: January 2025

IntroductionThough some studies have found the positive influences of moderate self-deception on individuals and society, there are many that have shown its negative influences on individuals and society. Long-term self-deception will have negative influences which could cause high individual losses and even social disasters. Therefore, it is essential to abate the decay of self-deception to avoid its negative influences and help individuals to better monitor themselves.MethodsIn this research, we explored the impact of various types of negative feedback on the decay of self-deception using a forward-looking paradigm with three conditions: no-feedback, ambiguous negative feedback, and real negative feedback. The experiment under each condition was tested four times. The negative feedback was provided after Tests 2 and 3.ResultsThe results indicated that, in Test 1 of both Experiments 1 and 2, the answer group demonstrated notably stronger positive beliefs and a higher propensity for cheating compared to the control group. Additionally, self-deception was more pronounced under the no-feedback than under the negative feedback in the subsequent three tests. Furthermore, the condition of ambiguous negative feedback led to greater self-deception in the final three tests compared to the condition of real negative feedback in Experiment 2. The results also revealed that self-deception gradually diminished with real feedback in the answer group.DiscussionThe findings showed that both ambiguous and real negative feedback reduce self-deception, although real negative feedback having a greater effect than ambiguous feedback. Additionally, the reduction of self-deception was fundamentally related to a decrease in unrealistic positive beliefs, and this decline in self-deception was also influenced by monetary rewards.
Effects of physical activity participation on subjective well-being of Chinese residents: mediating effects of physical health status and perceived social development
Authors: Wei Pingqiang , Qin Ting , Zhu Chengyi 
Published: January 2025

BackgroundPhysical exercise participation can effectively improve the subjective well-being of Chinese residents; however, further research is needed to understand how this participation influences their well-being. This study aims to explore the influence mechanism of physical exercise participation on the subjective well-being of Chinese residents and the mediating role of physical health status and social development cognition in this relationship.MethodsBased on the data from China’s comprehensive social survey in 2021, 7,923 valid samples were selected. Three variables, such as physical exercise participation, physical health status, and social development cognition, were used to explore residents’ subjective well-being. Multiple linear regression models, structural equation models, and bootstrap methods were employed to assess the mediating effects of these variables.Results(1) Physical exercise participation can improve residents’ subjective well-being (β=0.084, t = 4.67) and promote the development of positive psychology. (2) Physical health status has a mediating effect on the impact of physical exercise participation on residents’ subjective well-being, with a mediating effect calculated at 0.05 (95% CI [0.01, 0.09]). (3) The cognitive level of social development has a mediating effect on the influence of physical exercise participation on residents’ subjective well-being, with a documented mediating effect of 0.04 (95% CI [0.01, 0.08]). (4) Both physical health status and social development cognition collectively exhibit a chain mediating effect on the relationship between physical exercise and subjective well-being, with a combined mediating effect of 0.07 (95% CI [0.04, 0.10]).ConclusionParticipation in physical activity has a positive effect on residents’ subjective well-being, with physical health status and social development cognition serving as chain mediators in this relationship. Consequently, it is recommended that both government and various societal sectors intensify efforts to promote physical activity. By creating supportive environments that facilitate regular physical exercise, we can enhance the health and happiness of the population at large.
Case report: Local anesthesia with lidocaine infiltration for extended-release buprenorphine therapy
Authors: Azar Pouya , Kim Jane J. , Rohani Ella , Newman-Azar Dayyon , Narimani Matin , Machado Jessica , Li Victor W. 
Published: January 2025

BackgroundExtended-release buprenorphine (BUP-XR) is a once-monthly subcutaneous injection for the treatment of opioid use disorder. Injection-site pain is a common adverse event reported with BUP-XR administration. Notwithstanding the advantages of BUP-XR, subjective pain and anxiety associated with injections can compromise patients’ willingness to receive treatment. Lidocaine is an amide-type agent and sodium channel blocker commonly used for local and regional anesthesia in various fields of medicine.Case presentationWe present two cases involving lidocaine infiltration to the induction phase of BUP-XR therapy in an outpatient setting. Prior to the intervention, 2 mL of 1% lidocaine was infiltrated subcutaneously at the sites of the planned needle insertion for a numbing effect. The following BUP-XR therapy was well tolerated by both participants and reported as a painless procedure.ConclusionsLidocaine infiltration may be a feasible way to successfully initiate and provide BUP-XR therapy to those who may be deterred by injection-related risks. Our cases describe how lidocaine can be useful in mitigating injection-site pain and encouraging greater uptake, and in turn, greater retention in opioid agonist therapy.
Impact of Comprehensive Health Insurance affiliation on mortality in children under one year: an analysis of the Demographic and Health Survey 2010–2022 in Peru
Authors: Espinola-Sánchez Marcos , Campaña-Acuña Andres , Urrunaga-Pastor Diego , Maguiña Jorge L. , Jumpa Manuel , Ugarte-Ubillus Oscar 
Published: January 2025

ObjectiveTo assess the impact of Comprehensive Health Insurance (CHI) coverage on mortality in children under 1 year of age in the Peruvian population from 2010 to 2022. Additionally, the study evaluated how CHI affects infant mortality according to wealth quintiles in the Peruvian population.MethodsA causal inference analysis with observational data was applied, employing propensity score matching. Participants included children under 1 year of age, surveyed through the National Demographic and Family Health Survey (ENDES) from 2010 to 2022. Variables measured included CHI affiliation and death in children under 1 year. Methods such as inverse probability weighting adjusted by regression, Average Treatment Effect on the Treated (ATET) estimation, and endogeneity test were applied.ResultsThe study population consisted of 26,319 children under 1 year, with 11,922 not affiliated with CHI and 14,397 affiliated. The ATET analysis as an exogenous treatment of CHI showed a significant reduction in infant mortality in the overall population of children by 12.6% (95% CI: 12.1 to 13.1%), in the poverty subgroup by 15.6% (95% CI: 14.9 to 16.3%), and in the non-poverty subgroup by 6% (95% CI: 5.5 to 6.4%). However, endogeneity was observed in the ATET for the non-poverty subgroup and for the overall population of children.ConclusionCHI affiliation contributes to reducing mortality in children under 1 year in the population with low economic incomes in Peru. However, this relationship is inconclusive for the general population and for the population with medium and high incomes, highlighting the importance of considering socioeconomic, demographic, and other insurance factors.
Risk perception of COVID-19, depressive symptoms and Internet addiction among undergraduates: a longitudinal study
Authors: Zhang Hongpo , Zhang Dandan , Ji Wanghua , Peng Shun 
Published: January 2025

BackgroundThe COVID-19 pandemic has caused serious negative psychological effects worldwide, relatively little research has been performed on the potential enduring effects of COVID-19 on people’s emotional health and Internet addiction. This study was to examine the longitudinal associations between risk perception of COVID-19, depressive symptoms, and Internet addiction among Chinese undergraduates.MethodsWe conducted a two-wave longitudinal survey by convenience sampling, a total of 1,153 Chinese undergraduate students completed questionnaires measuring their COVID-19 risk perception and post-traumatic growth (PTG) in December 2022 (T1) via an online survey. Subsequently, 1,008 of the T1 participants (87.42%) completed the depressive symptoms scale and Internet addiction scale 6 months later, in June 2023 (T2).Results(1) Risk perception of COVID-19 was significantly and positively predicted depressive symptoms and Internet addiction 6 months later; (2) Depressive symptoms played a mediating role between risk perceptions and Internet addiction; (3) PTG moderated the first-stage link between risk perception and Internet addiction, and this relationship was more robust for low PTG than for high PTG.ConclusionThese findings advance our understanding of the relationship and mechanisms between risk perception of COVID-19 and Internet addiction, and further support developing interventions to strengthen PTG for mitigating negative outcomes during major crises.
Attitudes and perspectives of healthcare workers on treating chronic hepatitis C infection in children and adolescents
Authors: Malik Farihah , Easterbrook Philippa , Indolfi Giuseppe , Thorne Claire 
Published: January 2025

Background and aimsThere are gaps in knowledge about the values and preferences of healthcare workers (HCW) with respect to treatment of children and adolescents living with chronic hepatitis C (HCV) infection. This study was carried out to identify these values and preferences as part of the evidence required to update World Health Organization (WHO) hepatitis C guidelines.MethodsAn online survey was designed and conducted during August/September 2021. Survey questions were developed to address two key questions about treatment of children and adolescents: who to treat, and which direct acting antiviral (DAA) regimens to use. The survey was circulated by the WHO to nine networks providing care to children and adolescents living with HCV infection, with respondents requested to cascade further within their networks.ResultsA total of 137 individuals from 38 countries responded to the survey. There was a trend toward higher preference for treating children of older age groups; 60% of respondents reported a strong preference for treating (i.e., stating they were very likely or likely to treat) children aged 3 to &lt;6 years, 81 and 95% indicated strong preferences for treating those aged 6 to &lt;12 years and 12 to &lt;18 years, respectively. The most preferred DAA regimens for treatment across all age groups were: sofosbuvir/velpatasvir (SOF/VEL), sofosbuvir/ledipasvir (SOF/LDV), and glecaprevir/pibrentasvir (GLE/PIB). These were also reported to be the most commonly available drug regimens at respondents’ facilities.ConclusionThis survey provides insights from a heterogenous sample of HCWs from across the world with respect to their expressed priorities and preferences for the treatment of children and adolescents with chronic HCV.
Assessment of post-partum physical exercise practice and its associated factors among women in postpartum period, in West Wollega zone, Oromia, Ethiopia
Authors: Yadeta Tegegne , Belema Daniel , Ahmad Seifedin , Sirage Nurye , Ali Abubeker Seid , Ali Kedir , Yimer Ali 
Published: January 2025

BackgroundThe postnatal period, spanning the initial 6 weeks after childbirth, brings about a range of difficulties for mothers globally, encompassing psychological, physiological, and biological shifts. Incorporating regular physical activity during this phase has demonstrated the potential to mitigate the chances of chronic metabolic disorders. Nevertheless, there is a lack of comprehensive understanding regarding women’s engagement in postpartum physical exercise during this time.MethodsThe research employed a community-based cross-sectional study design carried out between April 20 and May 20, 2023. A sample of 422 women was chosen through a simple random sampling method utilizing computer-generated random numbers. The data was inputted into Epi-Data 4.6 and processed with SPSS 26. Descriptive statistics and logistic regression were employed for the analysis. Variables with a p-value below 0.25 in the bi-variable analysis were included in the multivariable analysis, and those with a p-value under 0.05 in the multivariable analysis were considered as significantly associated factors. The results were presented using graphs and tables.ResultThis research involved 416 women, achieving a response rate of 98.6%. The prevalence of postpartum physical exercise practice among the participants was determined to be 19.5% (95% CI: 12.03–22.50). Several factors were independently associated with postpartum physical exercise practice: Women with a college education or higher had nearly three times greater odds of engaging in postpartum physical exercise (AOR = 2.97, 95% CI: 1.14, 7.80). Being employed in a government institution was associated with a 2.14 times higher likelihood of participating in postpartum physical exercise (AOR = 2.14; 95% CI: 1.96, 4.74). Primipara women had 2.8 times higher odds of practicing postpartum physical exercise (AOR = 2.80, 95% CI: 1.72, 4.59). Women who had exercised before pregnancy were more likely to continue postpartum physical exercise, with 5.1 times higher odds (AOR = 5.10; 95% CI: 2.78, 9.29). Possessing good knowledge about postpartum physical exercise was associated with 2.3 times greater odds of engaging in such exercise (AOR = 2.30; 95% CI: 1.20, 4.40).ConclusionThe study indicates that the majority of participants were not participating in postpartum physical exercise. Nevertheless, women with higher levels of education, government jobs, primipara mothers, prior exercise experience before pregnancy, and a good knowledge of postpartum physical exercise were more inclined to engage in it. These results underscore the need to increase awareness among healthcare providers and other relevant organizations about the advantages of postpartum physical exercise in preventing complications during the postpartum phase.
What factors influence the willingness and intensity of regular mobile physical activity?— A machine learning analysis based on a sample of 290 cities in China
Authors: Shen Hao , Shu Bo , Zhang Jian , Liu Yaoqian , Li Ali 
Published: January 2025

IntroductionThis study, based on Volunteered Geographic Information (VGI) and multi-source data, aims to construct an interpretable macro-scale analytical framework to explore the factors influencing urban physical activities. Using 290 prefecture-level cities in China as samples, it investigates the impact of socioeconomic, geographical, and built environment factors on both overall physical activity levels and specific types of mobile physical activities.MethodsMachine learning methods were employed to analyze the data systematically. Socioeconomic, geographical, and built environment indicators were used as explanatory variables to examine their influence on activity willingness and activity intensity across different types of physical activities (e.g., running, walking, cycling). Interaction effects and non-linear patterns were also assessed.ResultsThe study identified three key findings: (1) A significant difference exists between the influencing factors of activity willingness and activity intensity. Socioeconomic factors primarily drive activity willingness, whereas geographical and built environment factors have a stronger influence on activity intensity. (2) The effects of influencing factors vary significantly by activity type. Low-threshold activities (e.g., walking) tend to amplify both promotional and inhibitory effects of the factors. (3) Some influencing factors display typical non-linear effects, consistent with findings from micro-scale studies.DiscussionThe findings provide comprehensive theoretical support for understanding and optimizing physical activity among urban residents. Based on these results, the study proposes guideline-based macro-level intervention strategies aimed at improving urban physical activity through effective public resource allocation. These strategies can assist policymakers in developing more scientific and targeted approaches to promote physical activity.
Fortune, Long Life, and Luck in Battle: The Cult of the Three Devas and Worldly Rituals in Medieval Japan
Authors: Rappo Gaétan 
Published: January 2025

Dans le panthéon des divinités japonaises, il existe plusieurs figures auxquelles on attribue une efficacité particulière pour l’obtention de bienfaits concrets, dans la vie présente. Cet article analyse une triade de divinités, les trois Devas (santen) : Shōten (ou Kangiten), Benzaiten et surtout Dakiniten. Leur culte s’est développé à partir du Moyen Âge au sein du bouddhisme ésotérique Shingon, mais aussi Tendai, avant de se diffuser plus largement dans les textes shinto, notamment ceux qui concernaient la figure du dieu Inari, le Shugendō ou encore les pratiques religieuses des guerriers, ainsi que les rites martiaux destinés à soumettre ses ennemis. Après avoir examiné les origines de cette triade et analysé une série de rituels combinant des tables de divination de la voie du yin et du yang et des pratiques du bouddhisme ésotérique, cet article montre aussi la continuité de l’espace symbolique mis à contribution dans ces rites, ainsi que la constance – qui se retrouve même dans le vocabulaire – de leurs objectifs de richesse, de longévité, et surtout de chance sur le champ de bataille. Ainsi se dégagera une vue d’ensemble de l’évolution historique de cette constellation de rites, mythes et symboles, que l’on peut considérer comme un exemple particulièrement vivace d’une religiosité vécue.