bluuebunny/crossref_metadata_2025_split huggingface dataset:
Study on unconfined compressive strength and deformation characteristics of chlorine saline soil
Authors: Li Hongru , Yang Min 
Published: January 2024

AbstractThe distribution of saline soil is wide and the area is large in China. The saline soil in different regions shows their own characteristics. The saline soil of single salt is configured by adding different contents of NaCl to the loess in Xi'an. The effects of chlorine content and water content on soil strength and volume change in a large water content range was studied, and the change mechanism was analyzed by scanning electron microscopy. The results show that the strength of chloride saline soil increases with the decrease of water content. The moisture content of 12% is the critical point of strength change of chloride saline soil. When the moisture content is greater than 12%, the strength of soil decreases with the increase of salt content. When the water content is less than 12%, the strength of saline soil is 3% NaCl content > 1% NaCl content > 5% NaCl content > 0% NaCl content. The volume change of the sample consists of three parts: elastic deformation during sample pressing, volume shrinkage during water loss and salt expansion. In the absence of NaCl and 1% NaCl content, the sample was in the state of shrinkage during the loading process, in which with the decrease of moisture content shrinkage rate slowed down. The volume change rate of 3% and 5% NaCl showed an inflection point from negative to positive when the water content was 15%. When the water content is less than 12%, the saline soil with 3% NaCl content has the characteristics of high strength and unobvious salt expansion. The method of adding 3% NaCl to loess in Xi 'an area can be used to simulate the cement between soil particles, which provides a reference for artificially preparing structural soil. According to the microstructure analysis, the higher the salt content of saline soil, the smaller the soil pores, and the contact form of soil particles gradually develops from the point contact between soil particles to the salt-wrapped structure.
DGS-SCSO: Enhancing Sand Cat Swarm Optimization with Dynamic Pinhole Imaging and Golden Sine Algorithm for improved numerical optimization performance
Authors: Adegboye Oluwatayomi Rereloluwa , Feda Afi Kekeli , Ojekemi Oluwaseun Racheal , Agyekum Ephraim Bonah , Khan Baseem , Kamel Salah 
Published: January 2024

AbstractThis paper introduces DGS-SCSO, a novel optimizer derived from Sand Cat Swarm Optimization (SCSO), aiming to overcome inherent limitations in the original SCSO algorithm. The proposed optimizer integrates Dynamic Pinhole Imaging and Golden Sine Algorithm to mitigate issues like local optima entrapment, premature convergence, and delayed convergence. By leveraging the Dynamic Pinhole Imaging technique, DGS-SCSO enhances the optimizer's global exploration capability, while the Golden Sine Algorithm strategy improves exploitation, facilitating convergence towards optimal solutions. The algorithm's performance is systematically assessed across 20 standard benchmark functions, CEC2019 test functions, and two practical engineering problems. The outcome proves DGS-SCSO's superiority over the original SCSO algorithm, achieving an overall efficiency of 59.66% in 30 dimensions and 76.92% in 50 and 100 dimensions for optimization functions. It also demonstrated competitive results on engineering problems. Statistical analysis, including the Wilcoxon Rank Sum Test and Friedman Test, validate DGS-SCSO efficiency and significant improvement to the compared algorithms.
Spatio-temporal variation of noise pollution in South Paris during and outside the COVID-19 lockdowns
Authors: Abdmouleh M. A. , Dahech S. 
Published: January 2024

AbstractNoise pollution is one of the major environmental problems of contemporary societies. In urban areas, road transport is the main source impacting the spatio-temporal variation of air quality. This work aims to analyse the spatio-temporal variability of the noise level in the 13th arrondissement during peak hours, focusing on the comparison of noise levels between the COVID-19 lockdown and non-lockdown days. This paper provides data that could be used to evaluate noise mitigation options. Mobile surveys, using EXTECH 4017764 sensors, were used to cover 272 points. In this work, the mobile measurements use the median of instant noise levels measured every 5 s over a 5-min period during the peak period. This study confirms that road traffic appears to be the determining factor in noise pollution. The noise levels calculated in 2020 show a strong spatio-temporal variability explained by the proximity of the emission sources, but also that the noise level decreases by 6–10 dB (A) during the lockdowns. Indeed, near the main roads, 57–63 dB (A) are recorded during the lockdowns, compared to 67–72 dB (A) outside the lockdowns. Mainly the number of vehicles contribute to a large part of the noise level, to which the noise of construction sites can occasionally be added as in the south-eastern part of the study area.
A computational model of stem cells’ internal mechanism to recapitulate spatial patterning and maintain the self-organized pattern in the homeostasis state
Authors: Khorasani Najme , Sadeghi Mehdi 
Published: January 2024

AbstractThe complex functioning of multi-cellular tissue development relies on proper cell production rates to replace dead or differentiated specialized cells. Stem cells are critical for tissue development and maintenance, as they produce specialized cells to meet the tissues’ demands. In this study, we propose a computational model to investigate the stem cell’s mechanism, which generates the appropriate proportion of specialized cells, and distributes them to their correct position to form and maintain the organized structure in the population through intercellular reactions. Our computational model focuses on early development, where the populations overall behavior is determined by stem cells and signaling molecules. The model does not include complicated factors such as movement of specialized cells or outside signaling sources. The results indicate that in our model, the stem cells can organize the population into a desired spatial pattern, which demonstrates their ability to self-organize as long as the corresponding leading signal is present. We also investigate the impact of stochasticity, which provides desired non-genetic diversity; however, it can also break the proper boundaries of the desired spatial pattern. We further examine the role of the death rate in maintaining the system’s steady state. Overall, our study sheds light on the strategies employed by stem cells to organize specialized cells and maintain proper functionality. Our findings provide insight into the complex mechanisms involved in tissue development and maintenance, which could lead to new approaches in regenerative medicine and tissue engineering.
Modern analogs for ammonia flux from terrestrial hydrothermal features to the Archean atmosphere
Authors: Felix J. David 
Published: January 2024

AbstractThe isotopic composition of nitrogen in the rock record provides valuable evidence of reactive nitrogen sources and processing on early Earth, but the wide range of δ15N values (− 10.2 to + 50.4‰) leads to ambiguity in defining the early Precambrian nitrogen cycle. The high δ15N values have been explained by large fractionation associated with the onset of nitrification and/or fractionation produced by ammonia-ammonium equilibrium and water–air flux in alkaline paleolakes. Previous flux sensitivity studies in modern water bodies report alkaline pH is not a prerequisite and temperature can be the dominate parameter driving water–air flux. Here, I use the chemical and physical components of 1022 modern hydrothermal features to provide evidence that water–air NH3 flux produced a significant source of fixed nitrogen to early Earth’s atmosphere and biosphere. With regard to the modeled average NH3 flux (2.1 kg N m−2 year−1) and outlier removed average flux (1.2 kg N m−2 year−1), the Archean Earth’s surface would need to be 0.0092, and 0.017% terrestrial hydrothermal features, respectively, for the flux to match the annual amount of N produced by biogenic fixation on modern Earth. Water–air NH3 flux from terrestrial hydrothermal features may have played a significant role in supplying bioavailable nitrogen to early life.
Ppe.RPT/SSC-1: from QTL mapping to a predictive KASP test for ripening time and soluble solids concentration in peach
Authors: da Silva Linge Cassia , Fu Wanfang , Calle Alejandro , Rawandoozi Zena , Cai Lichun , Byrne David H. , Worthington Margaret , Gasic Ksenija 
Published: January 2024

AbstractGenomic regions associated with ripening time (RPT) and soluble solids concentration (SSC) were mapped using a pedigreed population including multiple F1 and F2 families from the Clemson University peach breeding program (CUPBP). RPT and SSC QTLs were consistently identified in two seasons (2011 and 2012) and the average datasets (average of two seasons). A target region spanning 10,981,971–11,298,736 bp on chromosome 4 of peach reference genome used for haplotype analysis revealed four haplotypes with significant differences in trait values among different diplotype combinations. Favorable alleles at the target region for both RPT and SSC were determined and a DNA test for predicting RPT and SSC was developed. Two Kompetitive Allele Specific PCR (KASP) assays were validated on 84 peach cultivars and 163 seedlings from the CUPBP, with only one assay (Ppe.RPT/SSC-1) needed to predict between early and late-season ripening cultivars and low and high SSC. These results advance our understanding of the genetic basis of RPT and SSC and facilitate selection of new peach cultivars with the desired RPT and SSC.
Biological structural study of emerging shaped nanoparticles for the blood flow in diverging tapered stenosed arteries to see their application in drug delivery
Authors: Akbar Noreen Sher , Habib M. Bilal , Rafiq Maimona , Muhammad Taseer , Alghamdi Metib 
Published: January 2024

AbstractThe magnetic force effects and differently shaped nano-particles in diverging tapering arteries having stenoses are being studied in current research via blood flow model. There hasn’t been any research done on using metallic nanoparticles of different shapes with water as the base fluid. A radially symmetric but axially non-symmetric stenosis is used to depict the blood flow. Another significant aspect of our research is the study of symmetrical distribution of wall shearing stresses in connection with resistive impedance, as well as the rise of these quantities with the progression of stenosis. Shaping nanoparticles in accordance with the understanding of blood flow in arteries offers numerous possibilities for improving drug delivery, targeted therapies, and diagnostic imaging in the context of cardiovascular and other vascular-related diseases. Exact solutions for different flow quantities namely velocity, temperature, resistance impedance, boundary shear stress, and shearing stress at the stenosis throat, have been assessed. For various parameters of relevance for Cu-water, the graphical results of several types of tapered arteries (i.e. diverging tapering) have been explored.
Mechanical property analysis and dry sand three-body abrasive wear behaviour of AZ31/ZrO2 composites produced by stir casting
Authors: Kumar T. Satish , Raghu R. , Thankachan Titus , Čep Robert , Kalita Kanak 
Published: January 2024

AbstractAn experimental study of three body abrasive wear behaviour of AZ31/15 vol.% Zirconium dioxide (ZrO2) reinforced composites prepared by stir casting has been carried out. Microstructural analysis of the developed composites was carried out and found out that the microstructure of the composites revealed a uniform distribution of ZrO2 particles with refinement in the grain size of the matrix from 70 to 20 µm. The alterations in the microstructure led to an enhancement in both hardness (68–104 HV) and tensile strength (156–236 MPa) due to Orowan strengthening, quench hardening effect and better bonding. Response surface methodology was applied to formulate the three-body abrasive wear test characteristics such as load, speed, and time. Three body abrasive test results were utilized to generate surface graphs for different combinations of wear test parameters revealed an increase in specific wear rate. The specific wear rate was observed to increase with increase in speed up to a certain level and then started to decrease. The lowest possible specific wear rate was obtained for an optimized load of 20 N and a speed of 190 ms−1. Scanning electron microscopic examination of wear-tested samples showed higher specific wear rate at higher loads with predominantly abrasion type material removal. In conclusion, this study makes a substantial contribution to the field by elucidating the complex relationships among microstructure, mechanical properties, and the three-body abrasive wear behavior of AZ31/ZrO2 composites. The determination of optimal wear conditions and the insights gained into wear mechanisms provide valuable information for designing materials, implementing engineering solutions, and advancing the creation of wear-resistant components across a range of industries.
GC/MS and LC/MS serum metabolomic analysis of Chinese LN patients
Authors: Wang Wei , Kou Jun , Long Jie , Wang Tao , Zhang Mingmei , Wei Meng , Xie Qingyun 
Published: January 2024

AbstractChina, being a densely populated nation, faces a substantial economic burden due to a high incidence of lupus nephritis (LN) cases. The concealed onset of LN has resulted in many individuals have missed the optimal timing for treatment. The aim of the research is to study the serum metabolomics of Chinese LN patients using gas chromatography (GC)/mass spectrometry (MS) and liquid chromatography (LC)/MS to identify potential diagnostic markers. Fifty LN patients and fifty normal controls, matched for Body Mass Index (BMI) and age, were selected. Serum analysis was conducted using GC/MS and LC/MS, followed by multivariate statistical analysis. Various multidimensional analyses, including principal component analysis, partial least squares discrimination analysis, and orthogonal partial least squares discrimination analysis, along with one-dimensional analyses such as t-tests, were performed. Metabolites with variable importance in projection value > 1 and a p-value < 0.05 were considered critical biomarkers for LN. Furthermore, identified biomarkers delineated relevant metabolic pathways, and a metabolic pathway map was obtained from the database. Forty-one metabolites were identified as potential LN biomarkers, primarily associated with immune regulation, energy metabolism, intestinal microbial metabolism, renal damage, and oxidative stress. The potential for diagnosing LN and other diseases through metabolomics is demonstrated. Future research should explore larger sample sizes, metabolomic comparisons across different diseases and health states, and integration of metabolomics with clinical diagnostics. Such studies will enhance the understanding of metabolomics in medical diagnosis and provide robust support for its practical application.
The infinitesimal deformations of hypersurfaces that preserve the Gauss map
Authors: Dajczer Marcos , Jimenez Miguel 
Published: January 2024

Classifying the nonflat hypersurfaces in Euclidean space

f
:

M
n

→

R

n
+
1

f\colon M^n\to \mathbb {R}^{n+1}

that locally admit smooth infinitesimal deformations that preserve the Gauss map infinitesimally was a problem only considered by Schouten in 1928 [Proceedings Amsterdam 31 (1928), pp. 208–218]. He found two conditions that are necessary and sufficient, with the first one being the minimality of the submanifold. The second is a technical condition that does not clarify much about the geometric nature of the hypersurface. In that respect, the parametric solution of the problem given in this note yields that the submanifold has to be Kaehler.
YTHDF2-regulated matrilin-3 mitigates post-reperfusion hemorrhagic transformation in ischemic stroke via the PI3K/AKT pathway
Authors: Chen Hanze , Guo Siping , Li Runnan , Yang Lihui , Wang Rui , Jiang Yasi , Hao Yonggang 
Published: January 2024

Abstract
Hemorrhagic transformation can complicate ischemic strokes after recanalization treatment within a time window that requires early intervention. To determine potential therapeutic effects of matrilin-3, rat cerebral ischemia-reperfusion was produced using transient middle cerebral artery occlusion (tMCAO); intracranial hemorrhage and infarct volumes were assayed through hemoglobin determination and 2,3,5-triphenyltetrazoliumchloride (TTC) staining, respectively. Oxygen-glucose deprivation (OGD) modeling of ischemia was performed on C8-D1A cells. Interactions between matrilin-3 and YTH N6-methyladenosine RNA binding protein F2 (YTHDF2) were determined using RNA immunoprecipitation assay and actinomycin D treatment. Reperfusion after tMCAO modeling increased hemorrhage, hemoglobin content, and infarct volumes; these were alleviated by matrilin treatment. Matrilin-3 was expressed at low levels and YTHDF2 was expressed at high levels in ischemic brains. In OGD-induced cells, matrilin-3 was negatively regulated by YTHDF2. Matrilin-3 overexpression downregulated p-PI3K/PI3K, p-AKT/AKT, ZO-1, VE-cadherin and occludin, and upregulated p-JNK/JNK in ischemic rat brains; these effects were reversed by LY294002 (a PI3K inhibitor). YTHDF2 knockdown inactivated the PI3K/AKT pathway, inhibited inflammation and decreased blood-brain barrier-related protein levels in cells; these effects were reversed by matrilin-3 deficiency. These results indicate that YTHDF2-regulated matrilin-3 protected ischemic rats against post-reperfusion hemorrhagic transformation via the PI3K/AKT pathway and that matrilin may have therapeutic potential in ischemic stroke.
Association of sleep quality on the night of operative day with postoperative delirium in elderly patients
Authors: Ou-yang Chun-lei , Ma Li-bin , Wu Xiao-dong , Ma Yu-long , Liu Yan-hong , Tong Li , Li Hao , Lou Jing-sheng , Cao Jiang-bei , Mi Wei-dong 
Published: January 2024

BACKGROUND
Sleep disturbances in the peri-operative period have been associated with adverse outcomes, including postoperative delirium (POD). However, research on sleep quality during the immediate postoperative period is limited.

OBJECTIVES
This study aimed to investigate the association between sleep quality on the night of the operative day assessed using the Sleep Quality Numeric Rating Scale (SQ-NRS), and the incidence of POD in a large cohort of surgical patients.

DESIGN
A prospective cohort study.

SETTING
A tertiary hospital in China.

PATIENTS
This study enrolled patients aged 65 years or older undergoing elective surgery under general anaesthesia. The participants were categorised into the sleep disturbance and no sleep disturbance groups according to their operative night SQ-NRS.

MAIN OUTCOME MEASURES
The primary outcome was delirium incidence, whereas the secondary outcomes included acute kidney injury, stroke, pulmonary infection, cardiovascular complications and all-cause mortality within 1 year postoperatively.

RESULTS
In total, 3072 patients were included in the analysis of this study. Among them, 791 (25.72%) experienced sleep disturbances on the night of operative day. Patients in the sleep disturbance group had a significantly higher risk of developing POD (adjusted OR 1.43, 95% CI 1.11 to 1.82, P = 0.005). Subgroup analysis revealed that age 65–75 years; male sex; ASA III and IV; haemoglobin more than 12 g l−1; intra-operative hypotension; surgical duration more than 120 min; and education 9 years or less were significantly associated with POD. No interaction was observed between the subgroups. No significant differences were observed in the secondary outcomes, such as acute kidney injury, stroke, pulmonary infection, cardiovascular complications and all-cause mortality within 1 year postoperatively.

CONCLUSIONS
The poor subjective sleep quality on the night of operative day was independently associated with increased POD risk, especially in certain subpopulations. Optimising peri-operative sleep may reduce POD. Further research should investigate potential mechanisms and causal relationships.

TRIAL REGISTRY
chictr.org.cn: ChiCTR1900028545.
Blood pressure lowering for kidney transplant recipients: systematic review with network meta-analysis
Authors: Natale Patrizia , Palmer Suetonia C. , Jaure Allison , Saglimbene Valeria , Iannone Andrea , Sluiter Amanda , Craig Jonathan , Strippoli Giovanni F.M. 
Published: January 2024

Objective:
Hypertension affects 50–90% of kidney transplant recipients and is associated with cardiovascular disease and graft loss. We aimed to evaluate the comparative benefits and harms of blood pressure lowering agents in people with a functioning kidney transplant.

Methods:
We conducted a systematic review with network meta-analysis of randomized controlled trials (RCTs). We searched MEDLINE, Embase, and CENTRAL through to October 2023. RCTs evaluating blood pressure lowering agents administered for at least 2 weeks in people with a functioning kidney transplant with and without preexisting hypertension were eligible. Two reviewers independently extracted data. The primary outcome was graft loss. Treatment effects were estimated using random effects network meta-analysis, with treatment effects expressed as an odds ratio (OR) for binary outcomes and mean difference (MD) for continuous outcomes together with their 95% confidence interval (CI). Confidence in the evidence was assessed using GRADE for network meta-analysis.

Results:
Ninety-four studies (7547 adults) were included. Two studies were conducted in children. No blood pressure-lowering agent reduced the risk of graft loss, withdrawal because of adverse events, death, cardiovascular or kidney outcomes compared with placebo/other drug class. Angiotensin-converting enzyme inhibitors and angiotensin receptor blocker therapy may incur greater odds of hyperkalemia compared with calcium channel blockers [odds ratio (OR) 5.48, 95% confidence interval (CI) 2.47–12.16; and OR 8.67, 95% CI 2.65–28.36; low certainty evidence, respectively).

Conclusion:
The evidentiary basis for the comparative benefits and safety of blood pressure lowering agents in people with a functioning kidney transplant is limited to guide treatment decision-making.