bluuebunny/crossref_metadata_2025_split huggingface dataset:
Not one but two invasions of the Atlantic Ocean from the Indo-Pacific: Genetic and morphologic study of the slug genus Vayssierea Risbec, 1928 (Mollusca, Nudibranchia)
Authors: Miralda Carla Canet , Moles Juan 
Published: November 2023

Abstract

Vayssierea is an understudied nudibranch genus characterized by its orange colouration and small size of up to 5 mm long. There are four described species so far, distributed in the Indo-Pacific Ocean. Here, individuals of Vayssierea have been recorded for the first time in the North Atlantic Ocean, in the Canary Islands (Spain). This study aims to evaluate the systematic and taxonomy status, and distribution of the genus through a multilocus phylogenetic analysis and a morphological and radular analysis. Phylogenetic results show the monophyly of the genus, with a particularly long branch that may represent its fast evolutionary rate compared to its counterparts. The systematics of the genus are clarified, and we provide evidence that Vayssierea is included in the new subfamily Okadaiinae stat. nov. within Polyceridae. According to the species delimitation test, four different species have been sequenced from Russia to Australia in the Indo-Pacific plus our records from the Atlantic, but more information is needed to identify them. Nevertheless, our specimens from the Canary Islands correspond to two different species, one identical to the Australian species. Bearing in mind they lack a planktonic larval phase, we hypothesize that they have arrived by shipping transportation or aquarium releases, becoming an invasive species of the Atlantic Ocean.
Feasibility study of low-dose CT technology for maxillofacial bone 3D printing in skeletal class III malocclusion
Authors: Li Guan , Chen Wei , Shao Yang , Miao Qian , Wang Jinbao , Zhang Bing 
Published: November 2023

Abstract
Background
Skeletal class III malocclusion is one of the most common dental and maxillofacial malformations. Three-dimensional (3D) printing technology has become widely applied in orthopaedics. The CT radiation dose experienced during the acquisition of data sources for 3D printing is a growing concern. This study explored the feasibility of low-dose CT technology in maxillofacial bone 3D printing and the clinical value of maxillofacial bone 3D printing in class III malocclusion.
Methods
Ninety patients with class III malocclusion who planned to undergo maxillofacial bone 3D printing and 3D-CT were prospectively enrolled and randomly divided into conventional CT dose 3D printing group (Group A, n = 28), low CT dose 3D printing group (Group B, n = 32) and 3D-CT control group (Group C, n = 30). A 4-point scale was adopted to evaluate the quality of maxillofacial bone 3D printing, and a Likert-scale questionnaire was used to assess its clinical value.
Results
No significant differences were observed in general demographic characteristics between Groups A, B and C. The radiation dose in Group B (0.3 mSv) was reduced by approximately 63% compared with that in Group A (0.8 mSv), and there were no significant differences between Groups A and B in 3D printing quality indexes (includes to clarity, integrity, accuracy or artefacts) (all P > 0.05). There were significantly higher subjective scores for the clinical value of maxillofacial bone 3D printing than for 3D-CT in diagnosing and classifying, formulating the surgical plan, simulating the surgical process and predicting postoperative recovery (all P < 0.05).
Conclusions
Low-dose CT technology can be effectively applied for maxillofacial bone 3D printing, reducing the radiation dose without affecting the 3D printing quality. Maxillofacial bone 3D printing technology is superior to 3D-CT in class III malformations.
Molecular and entomological surveillance of malaria vectors in urban and rural communities of Benguela Province, Angola
Authors: Alves Gonçalo , Troco Arlete Dina , Seixas Gonçalo , Pabst Rebecca , Francisco Alfredo , Pedro Cani , Garcia Luzala , Martins José Franco , Lopes Sérgio 
Published: November 2023

Abstract
Background: Malaria is a major public health problem in Angola, with Anopheles gambiae s.l. and An. funestus s.l. being the primary vectors. This study aimed to clarify the information gaps concerning the abundance, geographical dispersion, blood feeding patterns, and insecticide resistance of local Anopheles spp. populations using molecular methods to identify sibling species, the origin of blood meals, Plasmodium falciparuminfection rates, and the presence of knockdown resistance (kdr) mutations.
Methods: Adult mosquitoes were collected indoors using CDC light traps from nine randomly selected households at two sentinel sites with distinct ecological characteristics. The samples were collected from 1 February to 30 June 2022. Anopheles mosquitoes were morphologically identified and subjected to molecular identification. Unfed Anopheles females were tested for the presence of Plasmodium falciparum DNA in head and thorax, and engorged females were screened for the source of the blood-meals. Additionally, members of An. gambiae complex were genotyped for the presence of the L1014F and L1014S kdr mutations.
Results: In total, 2,226 adult mosquitoes were collected, including 733 Anopheles females. Molecular identification revealed the presence of Anopheles coluzzi, An. gambiae s.s., An. arabiensis, and An. funestus s.s. Notably, there was the first record of An. coluzzi/An. gambiae s.s. hybrid and An. vaneedeni in Benguela province. Plasmodium falciparuminfection rates for Anopheles coluzzii at the urban sentinel site and Anopheles funestus s.s. at the rural site were 23.1% and 5.7%, respectively. The L1014F kdr mutation was discovered in both resistant and susceptible An. coluzzii mosquitoes, while the L1014S mutation was detected in An. gambiae s.s. for the first time in Benguela province. No kdr mutations were found in the An. arabiensis.
Conclusions: This study provides valuable insights into the molecular characteristics of malaria vectors from the province of Benguela, emphasising the need for continuous surveillance of local Anophelespopulations regarding the establishment of both kdr mutations for tailoring vector control interventions.
Does Desmopressin Impact Lateralization in Bilateral Inferior Petrosal Sinus Sampling?
Authors: Erkan Buruc , Cil Mehmet Said , Cingoz Mehmet , Burhan Sebnem , Aksoy Seyma , Yuzkan Sabahattin , Akpinar Ebubekir , Tanriverdi Osman , Kocak Burak , Cakır Ilkay , Ciftci Sema , Ozturk Feyza Yener , Gunaldi Omur , Altuntas Yuksel , Hatipoglu Esra Suheda 
Published: November 2023

Abstract
Purpose
Bilateral inferior petrosal sinus sampling (BIPSS) is considered the gold standard method for localizing the source of Adrenocorticotropic Hormone (ACTH)-dependent Cushing's Syndrome (CS). While Corticotropin-releasing Hormone (CRH) was initially used as the primary stimulant for this procedure, Desmopressin has become a more common alternative. This study aims to investigate the efficacy of Desmopressin stimulation in BIPSS for cases of ACTH-dependent CS in comparison to CRH stimulation.
Methods
This study included a total of 25 individuals diagnosed with ACTH-dependent CS who underwent BIPSS and subsequently confirmed the diagnosis after endoscopic endonasal transsphenoidal pituitary surgery (EETPS). Of these participants, 15 were subjected to BIPSS with CRH stimulation, while the remaining 10 received Desmopressin stimulation. Comparative analysis was performed to assess the results obtained from these two groups.
Results
The overall sensitivity and specificity of Bilateral Inferior Petrosal Sinus Sampling (BIPSS) were both 100%. When utilizing CRH stimulation, the sensitivity and specificity of the procedure remained at 100%. Sensitivity with Desmopressin stimulation was also 100%; however, the specificity for the desmopressin group could not be calculated as none of the cases had a non-pituitary source. BIPSS demonstrated accurate lateralization in 74% of the cases. In contrast, the accuracy of lateralization with CRH stimulation was 58%, while it reached 100% after Desmopressin stimulation (p = 0.04).
Conclusion
The accuracy of Desmopressin and CRH stimulation in BIPSS for distinguishing ACTH-dependent CS is comparable. Furthermore, Desmopressin may enhance the precision of BIPSS lateralization.
KXH 3 (X = Ca, Sc, Ti, Ni) Hydride Perovskites: A DFT Study for Physical Properties and Hydrogen Storage Capability
Authors: Rehman Muhammad Awais , Rehman Zia ur , Usman Muhammad , Farrukh Usama , Ahmad Naushad , Ahmad Tehreem , Hamad Abu 
Published: November 2023

Abstract
The present study has been performed with the help of density functional theory to investigate structural, electronic, hydrogen storage, mechanical, thermal, and optical properties of KXH3 (X = Ca, Sc, Ti, & Ni) hydride perovskites. The lattice parameters are calculated by using the GGA-PBE functional and are found as 4.482 Å, 4.154 Å, 3.974 Å, and 3.686 Å for KCaH3, KScH3, KTiH3, and KNiH3, respectively. The electronic properties reveal that all the materials exhibit metallic behavior except KCaH3, which shows a semiconducting behavior. The population analysis suggests these compounds can store hydrogen due to their strong bonds and long bond lengths. The dynamic and mechanical stability predict that studied materials can be experimentally synthesized as the materials are thermodynamically and mechanically stable. The gravimetric ratio of hydrogen storage capacities has been calculated as 3.646 wt%, 3.452 wt%, 3.346 wt%, and 3.005 wt% for KCaH3, KScH3, KTiH3, and KNiH3, respectively. The calculated temperatures for hydrogen desorption are as follows: 442.40 K for KCaH3, 518.68 K for KScH3, 592.47 K for KTiH3, and 614.82 K for KNiH3, the formation energy was analyzed in the range − 57.822 to -80.358 KJ/mol.H2. These parameters suggest that all the materials are capable of hydrogen storage applications.
A Data-Driven Approach: Investigating Prognostic Factors for Overall Survival in Breast Conserving Surgery (BCS) using Machine Learning
Authors: See Mee-Hoong , Tan Qing-Yi , Lai Lee-Lee , Ng Jing-Hui , Haleem Nadheerah Abd , Yahya Abqariyah , Lim Phaik-Eem , Wu Yang-Sheng , Ling Po-Yu , Pai Tun-Wen 
Published: November 2023

Abstract
Background
Breast-conserving surgery (BCS) is a viable treatment for early-stage breast cancer, but post-operative recurrence is a significant concern linked to mortality. This study leverages Machine Learning and healthcare data to better identify patients at risk of recurrence. The goal is to assess how effectively the model predicts survival factors in breast cancer patients post-BCS.
Methods
This study retrospectively analyzed 1518 breast cancer patients, of whom 430 were excluded due to unknown post-surgery recurrence status from January 1993 to June 2021 using XGBoost model, optimized with grid search and 5-fold cross-validation. Feature importance was determined using the Shapley value technique, and data was collected with SPSS Statistics, Version 28.0, IBM.
Results
The machine learning model showed high effectiveness in predicting patient outcomes, with notable metrics like accuracy (0.947) and precision (0.897). Key findings emphasize the importance of clear surgical margins and reveal that demographic factors like age and race significantly affect prognosis, while luminal subtype and comorbidity are less influential. These insights are crucial for understanding disease recurrence in breast cancer patients after BCS and radiotherapy.
Conclusion
The XGBoost machine learning model demonstrated outstanding predictive performance for outcomes in breast cancer patients receiving BCS and radiotherapy. It confirmed the critical importance of clear surgical margins during initial surgery for prognosis. Demographic factors, especially age and race, were identified as significant predictors of patient outcomes.
A Grid Model of Direct Conversion between Zenith Tropospheric Delay and Precipitable Water Vapor in Tropical Regions
Authors: Jiang Chunhua , Chen Shaoni , Wang Shuaimin , Gao Xiang , Zhu Huizhong , Lu Yangyang , Liu Guangsheng 
Published: November 2023

Abstract

To obtain high-accuracy post and real-time precipitable water vapor (PWV) with simple process when the measured meteorological parameters are unavailable, a grid direct conversion model of zenith tropospheric delay (ZTD) and PWV in tropical regions (named CZP) is proposed with the consideration of the characteristics of spatiotemporal changes based on ERA5 reanalysis data from 2016 to 2019. The results show that the CZP model has good performance at each grid points compared with ERA5 PWV. The comparison results with the GNSS PWV of 61 IGS stations in tropical regions show that the mean bias and root mean square (RMS) of CZP GNSS PWW are no more than 1.1 mm and 1.4 mm, respectively. Furthermore, the CZP GNSS PWV at the co-located stations demonstrates a remarkable correlation with the radiosonde PWV (RS PWV) with the mean correlation coefficient of 0.93 and the bias and RMS of CZP GNSS PWV with respect to RS PWV are 1.61 mm and 3.11 mm, respectively. Additionally, the real-time CZP PWV is compared with the PWV based on GPT3 model with respect to RS PWV after the real-time GNSS ZTD are estimated by Precise Point Positioning (PPP). The results indicate that the real-time CZP PWV has higher accuracy with mean bias and RMS of -0.55 and 3.55 mm, respectively. The above results verify the high accuracy and feasibility of the CZP model for retrieving post and real-time PWV in the absence of measured meteorological data.
Rare environmental and endogenous bacteria isolated from a captive Chinese cobra (Naja atra) with acute enteritis in Hainan, China
Authors: Guo Guiying , Di Zihao , Yang Nuo , Fan Lixia , Li Xuesong , Zeng Jifeng , Zheng Jiping 
Published: November 2023

Abstract
Background: Etiology was investigated of a case of moribund captive juvenileChinese cobra (Naja atra).
Methods: Necropsy, histopathology were described, and bacterial examination was performed.
Results: Acute enteritis was diagnosed for signs of intestinal bleeding and intacttissues. Opportunistic infection occurred including three intestinal inhabitant species (Providencia rettgeri isolated from trachea, Proteus penneri isolated from the lungs, and Proteus vulgaris isolated from the heart) and three environmental species (Bordetella trematum in lungs, Acinetobacter venetianus in liver, and Alcaligenes faecalis in kidneys and spleen).
Conclusions: Our findings implied the exogenous and endogenous bacterial infection would take place under the vulnerable and susceptible condition caused by acute enteritis, and for the first time highlighted abnormal invasions of A. faecalis in the spleen, P. vulgaris in the heart, and A. venetianus in the liver in wild Chinese cobra.
Exploring the Influence of Perceived Extroversion in Embodied Virtual Agents on Trust and Likability
Authors: Lithoxoidou Evdoxia Eirini , Stamos Angelos , Triantafyllidis Andreas , Georgiadis Charalampos , Avonds Joke , Altsitsiadis Efthymios , Giakoumis Dimitris , Votis Konstantinos , Dewitte Siegfried , Tzovaras Dimitrios , Eleftherakis George , Prescott Tony 
Published: November 2023

Abstract
Embodied virtual agents (EVAs) are increasingly used as means of communication with individuals in everyday life. However, first and foremost, these artificial intelligence technologies need to be trusted and liked if users are to widely adopt it. The utilization of implicit nonverbal cues, can play a key role in human-agent interaction by eliciting positive feelings, to stimulate adoption. The aim of this paper is to examine whether nonverbal cues applied to an embodied agent’s appearance, i.e., facial expressions and body posture cues, affect trust and likeability. In accordance with a prior human study categorizing non-verbal cues into extroverted and introverted categories, a selection of such non-verbal cues was made. Afterwards, 382 individuals recruited through Amazon Mechanical Turk agreed to participate in the study. Participants’ personality traits were assessed using the Big Five Inventory – 2S and agent’s perceived extroversion trait was defined with two items from the 10-item measurement of the Big Five. The results showed that an agent’s perceived extroversion class (introvert vs extrovert) based on facial expressions and body posture, was correctly identified by participants (p=.014). Besides, there is evidence for significant results verifying the similarity effect on trust (p <.01) but not on likability. Participants trusted more the agent that was perceived with similar level of extroversion but they liked more the agent perceived as extrovert regardless of their level of extroversion. Thus, manipulating perceived extroversion of EVAs may be an important factor which should be incorporated into human-agent interaction.
Intraoperative spectroscopic evaluation of sentinel lymph nodes in breast cancer surgery
Authors: Barkur Surekha , Boitor Radu A. , Mihai Raluca , Gopal Navarasi S Raja , Leeney Samuel , Koloydenko Alexey , Khout Hazem , Rakha Emad , Notingher Ioan 
Published: November 2023

Abstract

Purpose
Sentinel lymph node (SLN) biopsy is a standard procedure for patients with breast cancer and normal axilla on imaging. Positive SLNs on histological examination can lead to a subsequent surgery for axillary lymph node clearance (ALNC). Here we report a non-destructive technique based on autofluorescence (AF) imaging and Raman spectroscopy for intra-operative assessment of SLNs excised in breast cancer surgery.
Methods
A microscope integrating AF imaging and Raman spectroscopy modules AF was built to allow scanning of lymph node biopsy samples (AF imaging determined optimal sampling locations for Raman spectroscopy measurements). After optimisation of the AF image analysis and training a classification models based on data from 85 samples (scanning 20–30 minutes), the AF-Raman technique was tested on an independent set of 81 lymph nodes. Sensitivity and specificity were calculated using post-operative histology as a standard of reference.
Results
The area under the receiver operating characteristic (ROC) curve for the AF-Raman technique was 0.93. For a regime that maximised specificity (reduce risks of false positives), an accuracy of 97% specificity and 80% sensitivity was achieved. The main confounders for SLN metastasis were areas rich in histiocytes clusters, for which only few Raman spectra had been included in the training dataset.
Conclusions
This preliminary study indicates that with further development and extension of the training dataset (inclusion of Raman spectra of capsule and histiocytes clusters), the AF-Raman is a promising technique for intra-operative assessment of SLNs. Intra-operative detection of positive biopsy could avoid second surgery for axillary clearance.
How psychiatrists and psychiatry trainees perceive their social support, work and loneliness associated with depression?
Authors: Pitanupong Jarurin , Anantapong Kanthee , Aunjitsakul Warut 
Published: November 2023

Abstract
Background
This study aimed to survey the prevalence of depression and its associated factors (perceptions towards social support and work and loneliness) among psychiatrists and psychiatry trainees.
Methods
This cross-sectional study surveyed Thai psychiatrists and psychiatry trainees from January to February 2023 using an online questionnaire. The questionnaires consisted of 1) the demographic and work-related information; 2) perceptions towards social support and work; 3) the Patient Health Questionnaire-9 (PHQ-9) Thai version; and 4) the 6-item Revised UCLA Loneliness Scale Thai version. All data were analyzed using descriptive statistics, and the associated factors concerning depression were analyzed via multiple linear regression analyses.
Results
Of the 225 total participants, 52(23.1%) and 173 (76.9%) were psychiatry trainees and psychiatrists, respectively. Most of them were female (64.9%) with overall median age (interquatile) was 34 (30, 42) years. Regarding the PHQ-9 findings, the prevalence of depression among all participants was 12.4% (psychiatrists 13.9% and psychiatry trainees 7.7%). From regression analyses, depression was associated with loneliness and perceived levels of work satisfaction and work stress in psychiatrists, while in psychiatry trainees, depression was associated with loneliness and perceived level of ability to control work schedule.
Conclusions
13.9% and 7.7% of psychiatrists and psychiatry trainees, respectively, had depression. Loneliness and perception about work satisfaction, work stress, and ability to control the work schedule were key contributing factors to depression. Although the prevalence of depression in this study was not extremely high, action is required to reduce the depression rate among mental health personnel.
IRB / IEC Certification: 65-488-3-1
The L27 Domain of MPP7 enhances TAZ-YY1 Cooperation to Renew Muscle Stem Cells
Authors: Fan Chen-Ming , Shao Anwen , Kissil Joseph 
Published: November 2023

Abstract

Stem cells regenerate differentiated cells to maintain and repair tissues and organs. They also replenish themselves, i.e. self-renewal, for the regenerative process to last a lifetime. How stem cells renew is of critical biological and medical significance. Here we use the skeletal muscle stem cell (MuSC) to study this process. Using a combination of genetic, molecular, and biochemical approaches, we show that MPP7, AMOT, and TAZ/YAP form a complex that activates a common set of target genes. Among these targets, Carm1 can direct MuSC renewal. In the absence of MPP7, TAZ can support regenerative progenitors and activate Carm1 expression, but not to a level needed for self-renewal. Facilitated by the actin polymerization-responsive AMOT, TAZ recruits the L27 domain of MPP7 to up-regulate Carm1 to the level necessary to drive MuSC renewal. The promoter of Carm1, and those of other common downstream genes, also contain binding site(s) for YY1. We further demonstrate that the L27 domain of MPP7 enhances the interaction between TAZ and YY1 to activate Carm1. Our results define a renewal transcriptional program embedded within the progenitor program, by selectively up-regulating key gene(s) within the latter, through the combination of protein interactions and in a manner dependent on the promoter context.
Integrating Climate Change Variables in Relative Humidity Prediction with Multivariate ARIMA and RNN Models
Authors: Sarker Rana , Rasel H. M. , Hossain ABM Shafkat , Mamun Abdullah Al , Saki Saleh Ahmad , Saleh Md. Abu 
Published: November 2023

Abstract
The study of relative humidity has gained significant attention in recent years due to its influence on climate change along with the global warming phenomenon. The precise prediction of these phenomena is crucial in various fields, encompassing meteorology, climate simulation, industrial production, agriculture, public health, and epidemiology. Nevertheless, the task of predicting relative humidity remains a persistent issue owing to its vulnerability to various climate-related influences. The current research employs two techniques, specifically Multivariate ARIMA and RNN models, in order to predict the monthly relative humidity in Chapainawabganj, Bangladesh. This study examines the interconnections of climate change, global warming, and Relative Humidity by incorporating many associated factors such as precipitation, wind speed, palmer drought severity index, and temperature. We employ data from the period spanning 1981 to 2011 for the purpose of training our model, whereas data from the years 2012 to 2021 is used exclusively for testing. In the study area, the proposed model had the lowest root mean squared error (5.10–5.65), the lowest mean absolute error (3.76-4.22), the highest correlation coefficients (0.95-0.96), the highest coefficients of determination (0.90-0.92), and the highest Willmott's index of agreement (0.98) for predicting relative humidity. The study concludes that the Multivariate RNN model (a non-linear model) exhibits superior performance in predicting relative humidity compared to the Multivariate ARIMA model (a statistical model). Our model could help to predict relative humidity across the world incorporating the effects of climate change.