bluuebunny/crossref_metadata_2025_split huggingface dataset:
Rosai-Dorfman disease of the breast: a case report
Authors: Bahary Youssef 
Published: October 2023

Abstract
Rosai-Dorfman disease is a benign proliferative disorder of histiocytes that typically involves the cervical lymph nodes in children and young adults. Extranodal Rosai-Dorfman disease develops in a considerable number of patients; however, Rosai-Dorfman disease of the breast is rarely encountered and may mimic malignancy. We present a 57-year-old woman who was seen for a painless firm mass in the upper outer quadrant of her right breast. Biopsy of the mass showed granulomatous mastitis, and the patient underwent surgical excision subsequently. Gross examination revealed one poorly circumscribed, vaguely lobulated, and variegated mass measuring 3.8 x 3.8 x 2.6 cm. Histology was notable for a marked lymphohistiocytic infiltrate with no identifiable breast tissue. The histiocytes were large with round nuclei and voluminous cytoplasm and demonstrated emperipolesis. Immunohistochemical studies showed that the histiocytes expressed S100, and the lymphocytic infiltrate was composed of CD3-postive T cells and CD20-postive B cells. Also, staining for IgG and IgG4 highlighted plasma cells with IG4-positive ones comprising < 10% of the plasma cell population. The histiocytes did not express CD1a. Pancytokeratin stain was negative, and the Ki-67 proliferation index was low. These findings were most consistent with Rosai-Dorfman disease. As we illustrate in this case study, Rosai-Dorfman disease of the breast can present with a firm and painless mass, posing a diagnostic challenge clinically and radiologically. Therefore, it is crucial to establish the correct diagnosis to avoid aggressive surgical or chemotherapeutic treatment.
Influence of Vegetation Cover on the Abundance of Peccaries in an Area of Reforestation in southern Brazilian Amazonia
Authors: Palmeira Francesca Belem Lopes , Trinca Cristiano Trapé , Ferrari Stephen Francis 
Published: October 2023

Abstract
As spatial variation in vegetation cover may influence the abundance of species at a landscape scale, abundance estimates may clarify shifts in habitat use within a vegetation mosaic. In the present study, we used camera trapping and a dynamics mix model to estimate the abundance of the white-lipped (Tayassu pecari) and collared peccaries (Pecari tajacu) in a study area in southern Brazilian Amazonia. We focused on the variation between three vegetation types – primary forest, secondary forest, and forest plantation – as potential determinants of peccary abundance. The initial abundance (λ) of T. pecari was higher in primary forest in comparison with the secondary forest and plantation. By contrast, the λ of P. tajacu did not vary significantly with vegetation cover. The expected abundance of T. pecari correlated positively with the presence of primary forest, and negatively with secondary forest and plantation. No clear correlation was found between the abundance of P. tajacu and any type of vegetation cover, however. The results of the present study provide important insights into the influence of vegetation cover on the abundance and detection of peccaries, whose ecology is still relatively poorly understood.
Management of Periapical cyst using Beta Tricalcium Phosphate Bone Substitute and Platelet Rich Fibrin Membrane Following Enucleation
Authors: Pragya Kumari  , Shubham Sareen  
Published: October 2023

The pulp and periodontium are connected anatomically, functionally, and developmentally. It might be challenging to diagnose and arrange effective treatments when pulpal issues and inflammatory periodontal disease coexist. One of the most frequent oral cavity cysts is the radicular cyst, which is typically brought on by trauma or an infection. There are a number of techniques that are now being used to enhance postoperative recovery and hasten the repair and regeneration of the damaged area. An investigation revealed that a 38-years-old patient had a radicular cyst, which was initially treated by endodontic treatment of the involved teeth, followed by enucleation of the cyst and a further bone graft placement followed by Platelet rich fibrin membrane. The patient's main complaint was pain in lower front jaw region for two to three months. Patient also had few episodes of pus discharge on its own through the same region. After three months, there was an increase in clinical attachment level and a decrease in probing depth. There was a sizable bone fill, according to radiographic findings.
Recent Achievement in the Synthesis of Imidazoles
Authors: Hieu Tran Trung , Dung Vo Cong , Chung Nguyen Thi , Duc Dau Xuan 
Published: October 2023

Abstract:
Imidazole derivatives, which belong to 1,3-diazole family, have two nitrogen
atoms at 1 and 3 positions in the aromatic ring. Imidazole derivatives diversely appear
both in nature and synthetic sources. Some natural imidazoles play important roles in human
life such as histidine, histamine and biotin. Imidazole-based compounds possess a wide range
of bioactivities such as those including antimicrobial, anticancer, antiparasitic, antihypertensive,
antineuropathic and anti-inflammatory activities. Many compounds with imidazole skeleton
have been marketed as drugs in the market. The synthesis of imidazole derivatives has
drawn great attention of chemists and numerous articles on the synthesis of this class of heterocyclic
compound have been reported over the years. In this article, we will give a comprehensive
review on the synthesis of imidazoles which date back to 2013. In this articles, 182 studies on the synthesis
of imidazoles are summerized. The Debus–Radziszewski imidazole synthesis have still recceived great
attention of chemists and many articles have been published recently. Besides, a huge number of novel methods
have also developed. We have also tried to describe reaction mechanisms as much as we can. The work might
be useful for chemists who are involved in the synthesis of heterocycles or drug chemistry.
Insights into Quinoline in Context of Conventional versus Green Synthesis
Authors: Grover Taruna , Singh Navneet , Vaja Maulikkumar 
Published: October 2023

Abstract:
A relatively new field dubbed "green chemistry" seeks to achieve sustainability at
the molecular level. This topic has received a lot of interest in recent years because of its ability
to fulfill both environmental and economic goals through non-hazardous chemical innovation.
A number of substituted quinoline derivatives were synthesized using microwave irradiation
(MW), light irradiation, the presence of a non-biodegradable and recyclable catalyst, the
presence of nanoparticles under solvent-free conditions, or the use of a green solvent. High
target compound yields, fast reaction times, a simple workup process, the ability to reuse the
catalyst, and environmentally favorable settings are all advantages of this effective approach.
This study explores the synthesis of quinoline, a versatile heterocyclic compound with widespread
applications in pharmaceuticals, agrochemicals, and material science. The focus is on
comparing conventional and green synthesis methods and evaluating their respective advantages,
drawbacks, and environmental impacts. The transition from conventional to sustainable green methodologies
highlights the significance of reducing waste, energy consumption and toxic reagents in quinoline
synthesis.
Advancements of the CRISPR/Cas9 System in the Treatment of Liver
Cancer
Authors: Li Zhuoyu , Han Ziming 
Published: October 2023

Abstract:
In recent years, the CRISPR/Cas9 system has become a rapidly advancing gene editing
technology with significant advantages in various fields, particularly biomedicine. Liver cancer is
a severe malignancy that threatens human health and is primarily treated with surgery, radiotherapy,
and chemotherapy. However, surgery may not be suitable for advanced cases of liver cancer
with distant metastases. Moreover, radiotherapy and chemotherapy have low specificity and numerous
side effects that limit their effectiveness; therefore, more effective and safer treatments are
required. With the advancement of the biomolecular mechanism of cancer, CRISPR/Cas9 gene
editing technology has been widely used in the study of liver cancer to gain insights into gene
functions, establish tumor models, screen tumor phenotype-related genes, and perform gene therapy.
This review outlines the research progress of CRISPR/Cas9 gene editing technology in the
treatment of liver cancer and provides a relevant theoretical basis for its research and application
in the treatment of liver cancer.
Explore the Constituents and Mechanism of Traditional Chinese Medicine
Preparation Zhachong Shisan Pills Based on HPLC-QTOF-MS and
Network Pharmacology
Authors: Xin Yueqiang , Sang Yuli , Ji Xiang , Tang Manman , Chen Lijiang , Hao Yanjun , Lu Jing 
Published: October 2023

Introduction:
Th study aims to establish the chromatographic fingerprint of
Zhachong Shisan pills (ZSP), and to explore its active components and mechanism of analgesic
and anti-inflammatory action.

Method:
First, the Personal Compound Database and Library (PCDL) of ZSP was constructed
through literature mining, and then the chemical composition and fingerprint of methanol extractions
from 8 batches of ZSP were studied using High-Performance Liquid Chromatography
with Quadrupole Time-Of-Flight tandem Mass Spectrometry (HPLC-QTOF-MS) technology.
Furthermore, network pharmacology was used to explore the active compounds, potential targets,
and signal pathways of analgesic and anti-inflammatory activity of ZSP. A total of 102
compounds were detected in positive and negative ion mode.

Results:
Fifty-six characteristic peaks in positive ion mode and 78 characteristic peaks in negative
ion mode were confirmed as common peaks in the fingerprint of ZSP. Through network pharmacology
research, the effective components, key targets, and signal pathways of ZSP for the treatment
of cerebral apoplexy by analgesic and anti-inflammatory effects were all analyzed.

Conclusion:
This study explained the substance basis of the analgesic and anti-inflammatory
effects of Zhachong Shisan Pills, and explores its possible mechanisms, providing ideas for rational
clinical medication and in-depth pharmacological research.
A Novel Dual-labeled Peptide for Multimodal Imaging of EGFR with
L858R Mutation
Authors: Kim Myoung Hyoun , Kim Seul-Gi , Kim Dae-Weung 
Published: October 2023

Background:
The development of molecular imaging agents targeting epidermal
growth factor receptor (EGFR) with L858R mutation may help with the selection of non-small
cell lung carcinoma (NSCLCL) patients who may benefit from EFGR tyrosine kinase inhibitor
(TKI) therapy.

Objective:
In this study, we developed 99mTc STHHYYP-GHEG-ECGK-tetramethylrhodamine
(STHHYYP-ECGK-TAMRA) to target EGFR with L858R mutation in NSCLC tumors and verified
its probability as a molecular imaging agent

Methods:
Fmoc solid-phase peptide synthesis was used to synthesize STHHYYP-ECGKTAMRA.
99mTc labelled STHHYYP-ECGK-TAMRA was prepared. Gamma imaging, fluorescent
imaging and biodistribution were performed in murine models bearing NCI-H1975 and
NCI-H1650 tumors.

Results:
The binding affinity value (Kd) of 99mTc STHHYYP-ECGK-TAMRA was estimated to
be 130.6 ± 29.2 nM in NCI-H1975 cells. The gamma camera images showed a substantial uptake
of 99mTc STHHYYP-ECGK-TAMRA in the NCI-H1975 tumor. The % injected dose/gram
of the NCI-H1975 tumor tissue was 2.77 ± 0.70 and 3.48 ± 1.01 at 1 and 3 h, respectively.

Conclusion:
Specific binding of 99mTc STHHYYP-ECGK-TAMRA to L858R-mutated EGFRpositive
NCI-H1975 cells and tumors was demonstrated in in vivo and in vitro studies. The results
suggest that 99mTc STHHYYP-ECGK-TAMRA is a good candidate agent for dualmodality
imaging targeting EGFR with L858R mutation.
APPLICATION OF METHODS OF MANUAL THERAPY, KINESIOTHERAPY AND ELECTROMYOSTIMULATION FOR THORACALGIA ON THE BACKGROUND OF SPINE OSTEOCHONDROSIS
Authors: Borzykh N.O. , Roi I.V. , Barabash S.V. , Kudrin A.P. , Kovalenko O.O. 
Published: October 2023

Резюме. Мета. Визначити ефективність застосування методів мануальної терапії, кінезіотерапії та електроміостимуляції для покращення амплітуди в грудо-поперековому відділі хребта та зменшення болю при лікуванні пацієнтів з торакалгією на тлі остеохондрозу.
Матеріали і методи. В статті надано результати дослідження групи пацієнтів з торакалгією на тлі остеохондрозу та міофасціального больового синдрому (МФБС) 75 осіб, які перебували на лікуванні у реабілітаційному відділенні ДУ «ІТО НАМНУ». Пацієнтам було виконано фізикальне обстеження, яке полягало у визначенні активного діапазону руху в грудо-поперековому відділі хребта методом гоніометрії та оцінку болі за ВАШ при виконанні гоніометрії; пальпаторному обстеженні спазмованих м’язів та визначенні активних тригерних точок (ТТ). Повторне обстеження здійснювали через два тижні, один місяць та три місяці відновного лікування.
Результати. За результатами статистичного аналізу маємо загальний приріст амплітуди руху протягом 3-ох місячного курсу фізичної терапії (ФТ): при флексії ‒ серед пацієнтів без обмеження флексії на 17 % (p˂0,05), з обмеженням флексії на 42,4 % (p˂0,05); при екстензії: серед пацієнтів без обмеження на 12% (p>0,05), з обмеженням екстензії ‒ на 43,2 % (p˂0,05); при ротації: серед пацієнтів без обмеження ротації вправо на 6,2 %, вліво – 8 % (p>0,05); з обмеженням ротації: загальний приріст ротації вправо на 42 %, вліво – 53 %(p<0,05).
Відмічаємо зменшення больового синдрому протягом всього курсу ФТ при виконанні флексії на 2,4 бали (57 %), екстензії ‒ на 3,8 бали (66,7 %), ротації ‒ на 4,8 бали (73,8 %), при p<0,05. При пальпаторному обстеженні тригерної точки (ТТ) m. levator scapule та m. trapezius больовий синдром зменшився від 53 % до 70 % відповідно до локалізації (p<0,05).
Висновки. Застосування методів ФТ (мануальної терапії, електроміостимуляції та кінезіотерапії) підтвердило свою ефективність позитивною динамікою показників флексії, екстензії та ротації грудо-поперекового відділу хребта та зменшенні рівня больового синдрому при виконанні гоніометрії та пальпаторному обстеженні ТТ.
Characteristics Associated With Telemonitoring Use Among Patients With Chronic Heart Failure: Retrospective Cohort Study
Authors: Auener Stefan L , van Dulmen Simone A , Atsma Femke , van der Galiën Onno , Bellersen Louise , van Kimmenade Roland , Westert Gert P , Jeurissen Patrick P T 
Published: October 2023

Background
Chronic heart failure (HF) is a chronic disease affecting more than 64 million people worldwide, with an increasing prevalence and a high burden on individual patients and society. Telemonitoring may be able to mitigate some of this burden by increasing self-management and preventing use of the health care system. However, it is unknown to what degree telemonitoring has been adopted by hospitals and if the use of telemonitoring is associated with certain patient characteristics. Insight into the dissemination of this technology among hospitals and patients may inform strategies for further adoption.

Objective
We aimed to explore the use of telemonitoring among hospitals in the Netherlands and to identify patient characteristics associated with the use of telemonitoring for HF.

Methods
We performed a retrospective cohort study based on routinely collected health care claim data in the Netherlands. Descriptive analyses were used to gain insight in the adoption of telemonitoring for HF among hospitals in 2019. We used logistic multiple regression analyses to explore the associations between patient characteristics and telemonitoring use.

Results
Less than half (31/84, 37%) of all included hospitals had claims for telemonitoring, and 20% (17/84) of hospitals had more than 10 patients with telemonitoring claims. Within these 17 hospitals, a total of 7040 patients were treated for HF in 2019, of whom 5.8% (409/7040) incurred a telemonitoring claim. Odds ratios (ORs) for using telemonitoring were higher for male patients (adjusted OR 1.90, 95% CI 1.50-2.41) and patients with previous hospital treatment for HF (adjusted OR 1.76, 95% CI 1.39-2.24). ORs were lower for higher age categories and were lowest for the highest age category, that is, patients older than 80 years (OR 0.30, 95% CI 0.21-0.44) compared to the reference age category (18-59 years). Socioeconomic status, degree of multimorbidity, and excessive polypharmacy were not associated with the use of telemonitoring.

Conclusions
The use of reimbursed telemonitoring for HF was limited up to 2019, and our results suggest that large variation exists among hospitals. A lack of adoption is therefore not only due to a lack of diffusion among hospitals but also due to a lack of scaling up within hospitals that already deploy telemonitoring. Future studies should therefore focus on both kinds of adoption and how to facilitate these processes. Older patients, female patients, and patients with no previous hospital treatment for HF were less likely to use telemonitoring for HF. This shows that some patient groups are not served as much by telemonitoring as other patient groups. The underlying mechanism of the reported associations should be identified in order to gain a deeper understanding of telemonitoring use among different patient groups.
Fight Against the Mandatory COVID-19 Immunity Passport on Twitter: Natural Language Processing Study
Authors: Gable Jessica S M , Sauvayre Romy , Chauvière Cédric 
Published: October 2023

Background
To contain and curb the spread of COVID-19, the governments of countries around the world have used different strategies (lockdown, mandatory vaccination, immunity passports, voluntary social distancing, etc).

Objective
This study aims to examine the reactions produced by the public announcement of a binding political decision presented by the president of the French Republic, Emmanuel Macron, on July 12, 2021, which imposed vaccination on caregivers and an immunity passport on all French people to access restaurants, cinemas, bars, and so forth.

Methods
To measure these announcement reactions, 901,908 unique tweets posted on Twitter (Twitter Inc) between July 12 and August 11, 2021, were extracted. A neural network was constructed to examine the arguments of the tweets and to identify the types of arguments used by Twitter users.

Results
This study shows that in the debate about mandatory vaccination and immunity passports, mostly “con” arguments (399,803/847,725, 47%; χ26=952.8; P<.001) and “scientific” arguments (317,156/803,583, 39%; χ26=5006.8; P<.001) were used.

Conclusions
This study shows that during July and August 2021, social events permeating the public sphere and discussions about mandatory vaccination and immunity passports collided on Twitter. Moreover, a political decision based on scientific arguments led citizens to challenge it using pseudoscientific arguments contesting the effectiveness of vaccination and the validity of these political decisions.
Selecting an Ecological Momentary Assessment Platform: Tutorial for Researchers
Authors: Henry Lauren M , Hansen Eleanor , Chimoff Justin , Pokstis Kimberly , Kiderman Miryam , Naim Reut , Kossowsky Joe , Byrne Meghan E , Lopez-Guzman Silvia , Kircanski Katharina , Pine Daniel S , Brotman Melissa A 
Published: October 2023

Background
Although ecological momentary assessment (EMA) has been applied in psychological research for decades, delivery methods have evolved with the proliferation of digital technology. Technological advances have engendered opportunities for enhanced accessibility, convenience, measurement precision, and integration with wearable sensors. Notwithstanding, researchers must navigate novel complexities in EMA research design and implementation.

Objective
In this paper, we aimed to provide guidance on platform selection for clinical scientists launching EMA studies.

Methods
Our team includes diverse specialties in child and adolescent behavioral and mental health with varying expertise on EMA platforms (eg, users and developers). We (2 research sites) evaluated EMA platforms with the goal of identifying the platform or platforms with the best fit for our research. We created a list of extant EMA platforms; conducted a web-based review; considered institutional security, privacy, and data management requirements; met with developers; and evaluated each of the candidate EMA platforms for 1 week.

Results
We selected 2 different EMA platforms, rather than a single platform, for use at our 2 research sites. Our results underscore the importance of platform selection driven by individualized and prioritized laboratory needs; there is no single, ideal platform for EMA researchers. In addition, our project generated 11 considerations for researchers in selecting an EMA platform: (1) location; (2) developer involvement; (3) sample characteristics; (4) onboarding; (5) survey design features; (6) sampling scheme and scheduling; (7) viewing results; (8) dashboards; (9) security, privacy, and data management; (10) pricing and cost structure; and (11) future directions. Furthermore, our project yielded a suggested timeline for the EMA platform selection process.

Conclusions
This study will guide scientists initiating studies using EMA, an in vivo, real-time research tool with tremendous promise for facilitating advances in psychological assessment and intervention.
Development and Validation of a Formative Assessment Tool for Nephrology Fellows' Clinical Reasoning
Authors: Boyle Suzanne M. , Martindale James , Parsons Andrew S. , Sozio Stephen M. , Hilburg Rachel , Bahrainwala Jehan , Chan Lili , Stern Lauren D. , Warburton Karen M. 
Published: October 2023

Background
Diagnostic errors are commonly driven by failures in clinical reasoning. Deficits in clinical reasoning are common among graduate medical learners, including nephrology fellows. We created and validated an instrument to assess clinical reasoning in a national cohort of nephrology fellows and established performance thresholds for remedial coaching.

Methods
Experts in nephrology education and clinical reasoning remediation designed an instrument to measure clinical reasoning through a written patient encounter note from a web-based, simulated AKI consult. The instrument measured clinical reasoning in three domains: problem representation, differential diagnosis with justification, and diagnostic plan with justification. Inter-rater reliability was established in a pilot cohort (n=7 raters) of first-year nephrology fellows using a two-way random effects agreement intraclass correlation coefficient model. The instrument was then administered to a larger cohort of first-year fellows to establish performance standards for coaching using the Hofstee method (n=6 raters).

Results
In the pilot cohort, there were 15 fellows from four training program, and in the study cohort, there were 61 fellows from 20 training programs. The intraclass correlation coefficients for problem representation, differential diagnosis, and diagnostic plan were 0.90, 0.70, and 0.50, respectively. Passing thresholds (% total points) in problem representation, differential diagnosis, and diagnostic plan were 59%, 57%, and 62%, respectively. Fifty-nine percent (n=36) met the threshold for remedial coaching in at least one domain.

Conclusions
We provide validity evidence for a simulated AKI consult for formative assessment of clinical reasoning in nephrology fellows. Most fellows met criteria for coaching in at least one of three reasoning domains, demonstrating a need for learner assessment and instruction in clinical reasoning.