bluuebunny/crossref_metadata_2025_split huggingface dataset:
CANCER DE PELE NÃO MELANOMA: REVISÃO INTEGRATIVA
Authors: Gruber Cristiane Regina , Giovanini Allan Fernando , Skare Thelma Larocca , Rastelli Graziela Junges Crescente , Kubrusly Luiz Fernando , Sigwalt Marcos Fabiano , Tabushi Fernando Issamu , Manso Jose Eduardo Ferreira , Possiedi Rafael Dib 
Published: January 2024

Introdução: O câncer de pele não melanoma (CPNM) compeende grupo de neoplasias com alta incidência na população mundial. É dividido em carcinoma basocelular (CBC) e de células escamosas (CEC). Por ser de grande prevalência, entender o processo de oncogênese e a relação com íons, proteínas e receptores celulares no CPMN pode contribuir para que novas terapêuticas sejam avaliadas. Objetivo: Entender o processo da oncogênese dos tumores de pele não melanomas e sua relação com a imunolocalização do IP3R. Método: Revisão integrativa da literatura com síntese de evidências. A base de dados foi o PUBMED; a estratégia de busca: “carcinoma espinocelular, AND/OR carcinoma basocelular, AND/OR IP3R, AND/OR imunoistoquímica”. Foram considerados para revisão os trabalhos publicados entre 2018 e 2023. Foram incluídos 40 trabalhos, integralmente lidos e resumidos. Resultados: CPNMs são os tumores malignos mais comuns em todo o mundo, sendo 75-80% o CBC, e até 25% o CEC. As interações moleculares de forma geral, envolvem grande participação de moléculas supressoras tumorais, assim como de procto-oncogenes. Além disso, canais iônicos voltagem dependente controlam o fluxo citosólico de íons, dentre eles o cálcio. O IP3R (receptor do fosfatidil inositol-3) permite a saída de cálcio do retículo endoplasmático para que seja utilizado pela célula para atividades fisiológias como proliferação, angiogênese, motilidade e capacidade de invasão. Conclusão: O IP3R, pelas características de expressão imunoistoquímica, parece estar relacionado também, à fisiopatologia do CPNM.
O processamento de o mesmo como anáfora correferencial
Authors: Franzen Bruna Alexandra , Souza Ana Cláudia de 
Published: January 2024

Este trabalho tem por objetivo discutir sobre o processamento de “o mesmo” como anáfora correferencial, em contextos nos quais o pronome “ele” poderia ser utilizado, e seus possíveis efeitos na compreensão em leitura. Sabe-se que a anáfora tem importante papel na elaboração de um texto e no seu acesso e compreensão, o que a torna foco de muitos estudos desenvolvidos na área da linguística e da psicologia. Em uma relação correferencial, a forma de retomar um antecedente reflete, também, nos custos de processamento e, por conseguinte, pode afetar a representação mental do texto. Para abordar os aspectos elencados, mobilizam-se neste estudo fundamentos em torno dos processos envolvidos na leitura e, ainda, apresentam-se resultados de teste de leitura automonitorada realizado com 26 estudantes universitários. Para correlacionar o tempo de leitura foram analisadas duas medidas, a saber: o tempo total de leitura da sentença às quais os participantes foram expostos e o tempo de leitura do segmento pós-anafórico. Para além disso, foi avaliada, também, a acurácia das respostas às perguntas de controle de atenção. Embora haja uma visão negativa acerca do uso de “o mesmo” como anafórico, ele cumpre o papel que uma anáfora tem na progressão referencial de um texto, propiciando ao leitor a retomada do antecedente. Isso pode ser demonstrado por meio do resultado do teste ora reportado, no qual foi constatado que não houve diferenças estatisticamente significativas no que diz respeito ao processamento das variáveis testadas. Além disso, no que tange à pergunta de controle de atenção respondida pelos participantes, obtiveram-se os mesmos índices de acertos, tanto em conjuntos sentenciais construídos com “o mesmo” quanto com “ele”. Os estudos de processamento anafórico têm mostrado o pronome como um elemento linguístico de processamento mais rápido quando comparado à repetição do antecedente, uma vez que o pronome possui menos informações semânticas, o que evita sobrecarga da memória de trabalho. O sintagma “o mesmo”, por sua vez, parece seguir essa mesma lógica. Assim, a partir dos resultados obtidos por meio do teste de leitura automonitorada, o sintagma “o mesmo” parece atuar como elemento de retomada construindo cadeias coesivas e fazendo com que o referente previamente introduzido seja mantido no foco do leitor, da mesma forma que ocorre com o pronome.
Athletic Scholarships and Title IX: Compliance Trends and Context
Authors: Buzuvis Erin 
Published: January 2024

This article presents the current state of college & universities’ compliance with Title IX’s requirements for gender equity in the distribution of athletic financial aid, also known as athletic scholarships. When examined narrowly as a matter of compliance with the regulation governing athletic financial aid, scholarship allocation appears to favor female athletes. However, such framing focus obscures the degree to which women are short-changed in athletic scholarship dollars by college and universities constraining their athletic opportunities in the first place. This article provides updated analysis and figures about the degree to which that is so, as well as historic social and legal context. It also examines enforcement practices that affect compliance. Last, it offers suggestions for regulatory adjustment to add clarity to the concept of compliance in this regard.
Analysis and Visualization of High School Student Achievement Data Using Decision Tree and Cross-Validation in Rapidminer
Authors: Hartanta Radhitya Yunandri , Asroni Asroni , Riyadi Slamet , Jeckson Jeckson 
Published: January 2024

The vision, mission, and work indicators of high school education are all geared toward producing graduates of excellent quality. Students’ academic performance in the first and second grades indicates their eventual excellence as graduates. However, it is not feasible to ensure that students in the third year have good results only by comparing their academic achievements during the first and second grades. School leaders and policymakers can benefit from data analysis and visualization by gaining insight into recurring patterns and emerging trends in their stored data. Leaders and management at schools can benefit significantly from Rapidminer’s decision tree and cross-validation data analysis methods when trying to figure out what to do about students performing well or poorly academically.
Jantung, Medan magnet, Kesehatan KORELASI MASSA TUBUH TERHADAP DETAK JANTUNG PADA MENCIT BALB-C YANG DIPAPAR MEDAN MAGNET EXTREMELY LOW FREQUENCY (ELF) INTENSITAS 100 µT
Authors: Hindiyati Siti Hindun 
Published: January 2024

Paparan medan magnet Extremely Low Frequency (ELF) intensitas 100 µT telah di tetapkan sebagai nilai ambang batas efek kesehatan, namun masih perlu di kaji dampak biologis khususnya terhadap fungsi organ jantung. Penelitian ini bertujuan mengkaji “Korelasi Massa Tubuh Terhadap Detak Jantung Mencit Balb-C yang Dipapar Medan Magnet Extremely Low Frequency (ELF) Intensitas 100 µT”. Penelitian ini menggunakan True Design Experimen dengan rancangan acak lengkap (RAL), dengan memberi oerlakuan paparan medan magnet ELF intensitas 100 µT kepada mencit Balb/C secara intermiten 2 jam/hari selama 15 hari dan 30 hari. Sampel mencit Balb/c sejumlah 21 ekor di bagi dalam 3 kelompok, kelompok control , 2 kelompok di papar medan magnet ELF 100 µT secara intermiten 2 jam/hari selama 15 hari dan 30 hari. Variabel yang di ukur dalam penelitian ini adalah berat badan dan detak jantung per-detik. Pengukuran berat badan di lakukan menggunakan bantuan neraca digital ketelitian 0,00gr dengan 3 kali pengukuran disertai 3 pengamat sedangkan pengukuran detak jantung di lakukan dengan menghitung secara manual menggunakan indera manusia dibantu dengan menggunakan stopwatch sebagai pewaktu masing-masing 5 menit. Data hasil penelitian ini di analisis menggunakan analisis statistic korelasi menggunakan software SPSS 23. Hasil penelitian menunjukkan bahwa medan magnet ELF intensitas 100 µT hari ke-30 memiliki massa tubuh dan detak jantung lebih tinggi dibandingkan kelompok control. Hal ini disebabkan intensitas 100 µT menyebabkan adanya kerja otot berlebihan dalam jantung mencit Balb-C
Az egészségmagatartás tényezőinek változása a COVID-19 hatására
Authors: Pfau Christa , Kanyó Krisztina Zsófia 
Published: January 2024

The coronavirus pandemic caused profound changes in many aspects of people's lives, especially in the area of health behaviour. The restrictions caused by the pandemic have had negative effects on both the physical and mental health of society, while also transforming the way individuals exercise. The aim of our research was to analyse the changes in health behaviour of Hungarian adults, including their sporting habits as well as their mental health, caused by the COVID-19 pandemic. We also focused on comparing the experiences of a population that regularly participates in sport and a population that rarely or never participates in sport. Results of the survey showed that individuals who regularly participate in sport activities rated their general physical health significantly better than those living a more sedentary life. More than half of the sample stated that they did not experience any particular change in their physical health, but the second highest percentage of respondents reported that their health had been affected negatively by the pandemic period. Results also showed that almost half of respondents said that their sporting habits had not changed as a result of the pandemic, while many reported that their sporting frequency had decreased. Finally, we also analysed the changes in sporting habits with regard to the place of residence, finding that those individuals living in an apartment complex building were most likely to choose a different type of exercise from the one they had previously practised, while a higher proportion of individuals living in a suburban area, or with access to garden reported that they had started to doing sports.Our research provided partial confirmation that the pandemic had a negative effect on people's health behaviour, but given the high levels of exercise in the target group,it is not surprising that many did not experience any change in sporting habits or physical health.
JEL Code: I12
PENGEMBANGAN LEMBAR KERJA PESERTA DIDIK (LKPD) PADA MATERI POLA BILANGAN BERBASIS MASALAH KONTEKSTUAL BUDAYA BANJAR KELAS VIII SMP/MTS
Authors: Hariyadi Novia Salsabila , Zulkarnain Iskandar , Amalia Rizki 
Published: January 2024

Kurangnya ketersediaan bahan ajar matematika di sekolah yang mengaitkan dengan masalah kontekstual membuat para peserta didik kesulitan dalam memahami konsep suatu materi. Bahan ajar berupa LKPD yang digunakan juga tidak terdapat satupun yang mengaitkan materi dengan kebudayaan Banjar. Salah satu solusi untuk meningkatkan pemahaman konsep matematika adalah dengan menyediakan bahan ajar berupa Lembar Kerja Peserta Didik (LKPD) berbasis masalah kontekstual budaya Banjar. Penelitian ini bertujuan untuk menghasilkan LKPD pada materi pola bilangan berbasis masalah kontekstual budaya Banjar kelas VIII SMP/MTs yang valid, praktis, dan efektif. Penelitian ini menggunakan metode penelitian pengembangan model Plomp yang terdiri dari empat tahap, yaitu investigasi awal, desain, realisasi/konstruksi, serta tes, evaluasi, dan revisi. Uji coba dilakukan kepada 31 peserta didik kelas VIII E SMPN 24 Banjarmasin. Teknik pengumpulan data menggunakan instrumen validasi ahli, angket respon peserta didik, dan tes hasil belajar. Berdasarkan uji validitas oleh dua validator diperoleh rerata sebesar 3,22 dengan kriteria valid. Berdasarkan angket respon peserta didik diperoleh 3,32 dengan kriteria praktis. Berdasarkan tes hasil belajar diperoleh lebih dari 80% peserta didik mencapai nilai lebih dari sama dengan 75 sehingga dinyatakan efektif. Dengan demikian, dihasilkan LKPD pada materi pola bilangan berbasis masalah kontekstual budaya Banjar kelas VIII SMP/MTs yang valid, praktis, dan efektif.
PENGEMBANGAN SOAL KONTEKSTUAL BERBASIS KEARIFAN LOKAL PADA PEMBELAJARAN MATEMATIKA SMA/MA
Authors: Basriannor Agus , Zulkarnain Iskandar , Hidayanto Taufiq 
Published: January 2024

Matematika merupakan salah satu ilmu yang penting dalam kehidupan bahkan dalam perkembangan ilmu pengetahuan dan teknologi. Namun masih ada siswa yang mengalami kesulitan dalam memahami soal matematika. Hal tersebut karena soal yang diajukan terkesan membosankan dan terfokus pada masalah yang sulit dibayangkan oleh siswa. Oleh sebab itu, hendaknya siswa diberikan soal yang berhubungan dengan kehidupan secara nyata atau kontekstual. Tujuan penelitian ini adalah menghasilkan soal kontekstual berbasis kearifan lokal pada pembelajaran matematika SMA/MA yang valid dan praktis. Penelitian menggunakan metode penelitian dan pengembangan (Research and Development) dengan model pengembangan Tessmer tipe formative research mencakup tahap preliminary dan tahap formative evaluation yang terdiri dari self evaluation, expert reviews, one-to-one, small group, dan field test. Namun, pada penelitian ini hanya sampai pada small group. Pada penelitian ini pengumpulan data menggunakan istrumen validasi ahli dan angket respon siswa. Berdasarkan hasil analisis uji validitas yang diisi oleh tiga orang validator menghasilkan rata-rata skor 3,62 yang berada pada kategori valid. Kemudian, berdasarkan hasil analisis uji angket respon siswa menghasilkan rata-rata skor 3,32 yang menunjukkan bahwa soal berada pada kategori praktis. Dengan demikian, soal kontekstual berbasis kearifan lokal pada pembelajaran matematika SMA/MA memenuhi kriteria valid dan praktis.
Mediating Effect of Self-Control on the Relationship between Obesity Stress and Weight Control Behavior among Overweight and Obese Female College Students
Authors: Park Young-Hee , Jeong Yeo Won , Park Hyun kyeong , Park Seul-Gi , Kim Ha-Yeon 
Published: January 2024

Background: This study aimed to examine the obesity¬ stress, weight control behavior, and self-control in overweight and obese female university students, and identify the mediating effect of self-control in the relationship between obesity stress and weight control behavior.
Methods: This study employed a descriptive correlational design. A total of 109 female university students who were overweight and obese participated in the study. Data were analyzed using descriptive statistics, Pearson&#039;s correlation coefficient analysis, and Bootstrapping using Hayes&#039; PROCESS macro for mediation.
Results: Significant relationships between obesity stress and weight control behavior (r=0.25, p&lt;0.001), obesity stress and self-control (r=-0.36, p&lt;0.001), and weight control behavior and self-control (r=.26, p&lt;.001) were observed. Self-control showed indirect mediating effect on the relationship between obesity stress and weight control behavior.
Conclusion: Therefore, development of programs and strategies for improving self-control is necessary in order to decrease obesity among female university students.
ExomiRHub: a database to explore human extracellular and intracellular microRNA transcriptomics data
Authors: Liu Yang , Min Zhuochao , Mo Jing , Ju Zhen , Chen Jianliang , Li Hanguang , Liang Weiling , Chan Godfrey Chi-Fung , Wei Yanjie , Zhang Wenliang 
Published: January 2024

Abstract
Extracellular microRNA (miRNA) expression data, generated by different laboratories, exhibit heterogeneity, posing challenges for researchers lacking bioinformatics expertise to explore these valuable data. To expedite the discovery of clinically relevant miRNA biomarkers, a user-friendly database is mandatory. Therefore, we formulated ExomiRHub, a database that incorporates 191 human extracellular miRNA expression datasets associated with 112 disease phenotypes, 62 treatments, and 24 genotypes, including 29,198 samples and 23 sample types. To enhance usability, ExomiRHub integrates 16,012 miRNA transcriptomes of 156 cancer subtypes from The Cancer Genome Atlas. Instead of mere collection, ExomiRHub standardizes and annotates the datasets and samples with rich annotations. In addition, it offers 25 analytical and visualization functions to interpret these datasets for identification of non-invasive miRNA biomarkers. These 25 functions empower users to select samples, define groups, and set parameters for personalized analyses. Moreover, ExomiRHub offers a web service enabling users to conduct analyses on their uploaded data. To further assist users, four additional tools are designed for evaluating the functions and targets of miRNAs and their variations. In a notable application of ExomiRHub, we identified non-invasive miRNA biomarkers associated with angiogenesis for monitoring glioma progression. This exemplifies how ExomiRHub can significantly expedite the discovery of non-invasive miRNA biomarkers. ExomiRHub is available at http://www.biomedical-web.com/exomirhub/.
Utility of fluorescence-guided biopsy in suspected lung cancer patients with bronchial mucosal lesions
Authors: Wang Gaozhe , Jin Yan , Xiong Kunlong , Jin Xiaoyan , Wang Linfeng , Li Chenwei 
Published: January 2024

Abstract
Background: Bronchoscopy is currently the most commontechnique for lung cancer diagnosis. Patients suspected of malignancy often undergo bronchoscopic examination, and biopsy is routinely used in patients with visible bronchial lesions. However, it is difficult to differentially diagnose lung cancer in patients with bronchial mucosal lesions. Thus, this study was conducted to investigate the utility of fluorescence-guided biopsy in suspected lung cancer patients with bronchial mucosal lesions.
Methods: We conducted a retrospective studyin a single screening center to assess the sensitivity and specificity of fluorescence-guided biopsy compared with white light bronchoscopy (WLB) in patients with bronchial mucosal lesions.
Results: A total of 301 patients with bronchial mucosal lesions were enrolled in this study. The sensitivity for patients with fluorescence-guided biopsy was 60.3% (95% confidence interval [CI]: 53.1%-67.1%), which was higher than that of patients with WLB alone (45.2%, 95% CI: 38.2-52.4%) (P= 0.0026). Additionally, compared with the WLB group, the fluorescence -guided biopsy group was found to have a significantly higher specificity (100%, 95% CI: 95.5-100% versus 69.6%, 95% CI: 59.6-78.1%), positive predictive value (100%, 95% CI: 96.1-100% versus 74.3%, 95% CI: 65.5-81.7%) and negative predictive value (56.3%, 95% CI: 48.8-63.6% versus39.4%, 95% CI: 32.3-47.0%).
Conclusion: Fluorescence-guided biopsy can serve as an important adjunct to WLB for the differential diagnosis of lung cancer in patients with bronchial mucosal lesions.
Japanese preschool-aged children’s gratitude as a moral virtue: Is the development of gratitude culture-specific?
Authors: Kato-Shimizu Mayuko , Hinobayashi Toshihiko 
Published: January 2024

Abstract
The function of gratitude as a factor in forming reciprocal relationships has not yet been examined in preschool-aged children. This study examines how cultural differences may influence children’s expression and understanding of gratitude. Two vignettes involving a high- and low-cost situation of expressing gratitude were told to Japanese preschool-aged children, and their responses to the scenarios were recorded. Compared to American children, a certain number of Japanese children associated positive feelings with the benefactor when they helped, would help the benefactor if they were in need, and cited reciprocity as a reason for doing so. The findings confirmed that the sprouting of gratitude as a moral virtue is also observed in preschool children from non-Western countries, and commonalities in moral development across cultures were found. At the same time, depending on the cost incurred by the benefactor on offering help, we found cultural differences in various aspects of gratitude. The findings suggested that gratitude, which encompasses the norm of reciprocity, is triggered in Japanese children in response to the cost to the benefactor.
Interactive effects of selected pharmaceutical products (metronidazole, diclofenac, ibuprofen) and differently functionalized nanoplastics on marine algae Chlorella sp.
Authors: Rex Camil , Poddar Bikram , Das Soupam , Mukherjee Amitava 
Published: January 2024

Abstract
Pharmaceutical products (PPs) and nanoplastics (NPs) are two prevalent emerging contaminants that have garnered extensive environmental focus. The present study aimed to investigate both pristine and combined toxicity of PPs (metronidazole, diclofenac, and ibuprofen) and polystyrene NPs (with NH2 and COOH surface functionalization). Our findings suggest that Chlorella sp. experienced only a slight growth impediment when exposed to pristine PPs (1 mg/L). In contrast, PSNPs (1 mg/L) resulted in substantial growth inhibition. However, the combination of PPs and PSNPs showed a reduction in toxic effects when compared to pristine PSNPs. Additionally, independent action modeling revealed that the combination of PPs and PSNPs resulted in an antagonistic mode of interaction. Zeta potential analysis revealed the colloidal instability of PSNPs in the presence of PPs. This could have facilitated the aggregation and rapid settlement of PSNPs, consequently lessening their direct contact with the algal cells. Furthermore, ROS production significantly decreased in the combinations compared to the pristine PSNPs. This decrease in the ROS production subsequently led to a reduction in antioxidant activity and an enhancement in photosynthetic efficiency in the cells. These findings provide valuable insights into combined toxicity effects of PPs and PSNPs on primary producers like microalgae.
Waste reintroduced in the kitchen: life cycles inventories of representative waste-to-nutrition pathways
Authors: Javourez U. , Tituta-Barna L. , Hamelin L. 
Published: January 2024

Abstract
Waste recovery technologies targeting the formulation of edible ingredients such as insects, microorganisms, or proteins extracts, are increasingly promoted to mitigate global environmental impacts. Yet, many conversion pathways exist, and little is known about the plausibility, the implications, and the environmental relevance of deploying them: a comparative modeling approach is missing. To this end, we reviewed the available data and literature documenting these emerging biorefineries and compiled it into six harmonized life cycle inventory (LCI) models estimating the forecasted performances of 16 representative “waste-to-nutrition” pathways in function of 18 input stream characteristics and 293 technological parameters. Illustrated on eleven case studies, the results quantify the untapped potential of transforming waste into novel food and feed and unravel the intrinsic trade-offs between their energy intensity, their yield and the biochemical composition of input streams. We show that several scenarios are possible to achieve France’s protein feed autonomy by scaling and combining different waste-to-nutrition pathways, but that each scenario would lead to different consequences on energy systems and on bioresources’ mobilization requirements. As provided, the LCI models capture the implications associated with these waste recovery technologies and are ready to support their prospective life cycle assessment.