bluuebunny/crossref_metadata_2025_split huggingface dataset:
Changes in estimated glomerular filtration rate over the first year following repeat heart transplant in children and young adults
Authors: Chan Melvin , Silveira Lori , Patterson Daniel J. , Bock Margret E. , Pietra Biagio A. , Everitt Melanie D. , Simpson Kathleen E. , Miyamoto Shelley D. , Auerbach Scott R. 
Published: November 2023

AbstractBackgroundRenal function is reduced in patients undergoing heart transplant due to hemodynamic compromise, cardiorenal syndrome, and nephrotoxin exposure. No current studies evaluate renal function in retransplants.MethodsWe reviewed all heart transplants at our center from 1995 to 2021 and matched first‐time heart transplants with retransplants, based on age at transplant, sex, and race. Estimated glomerular filtration rate (eGFR) was derived from CKiD‐U25 calculator using creatinine and measured prior to transplant, 1‐week post‐transplant, 1–3, 6, and 12 months post‐transplant, and recent follow‐up. Changes in eGFR were measured within and between patients using a piecewise linear mixed effect model with matching. Exploratory univariate analysis was performed to evaluate pre‐transplant risk factors for decreased eGFR.ResultsThe unmatched cohort included 393 heart transplant recipients, with 47 being retransplants. Thirty‐eight patients in both groups with at least 1 year of follow‐up underwent matching. Both retransplants and first‐time transplants had an initial decline in eGFR. eGFR rebounded to baseline or above baseline at 1–3 months post‐transplant, but eGFR in retransplants remained significantly lower. At 1‐year post‐transplant, the average eGFR was 67.8 ± 4.3 mL/min/1.73 m2 versus 104.7 ± 4.3 mL/min/1.73 m2 (p < .001) in the retransplants and first‐time transplants group, respectively.ConclusionThis study provides data on anticipated renal trajectory following retransplantation.
Integrative analysis of physiology and genomics provides insights into freeze tolerance adaptations of Acacia koa along an elevational cline
Authors: Ebrahimi Aziz , Sugiyama Anna , Ayala‐Jacobo Lilian , Jacobs Douglass F. 
Published: November 2023

AbstractNatural selection for plant species in heterogeneous environments creates genetic variation for traits such as cold tolerance. While physiological or molecular analyses have been used to evaluate stress tolerance adaptations, combining these approaches may provide deeper insight. Acacia koa (koa) occurs from sea level to 2300 m in Hawaiʻi, USA. At high elevations, natural koa populations have declined due to deforestation, and freeze tolerance is a limiting factor for tree regeneration. We used physiology and molecular analyses to evaluate cold tolerance of koa populations from low (300–750 m), middle (750–1500 m), and high elevations (1500–2100 m). Half of the seedlings were cold acclimated by exposure to progressively lowered air temperatures for eight weeks (from 25.6/22.2°C to 8/4°C, day/night). Using the whole plant physiology‐freezing test and koa C‐repeat Binding Factor CBF genes, our results indicated that koa can be cold‐acclimated when exposed to low, non‐freezing temperatures. Seedlings from high elevations had consistently higher expression of Koa CBF genes associated with cold tolerance, helping to explain variation in cold‐hardy phenotypes. Evaluation of the genetic background of 22 koa families across the elevations with low coverage RNA sequencing indicated that high elevation koa had relatively low values of heterozygosity, suggesting that adaptation is more likely to arise in the middle and low elevation sources. This physiology and molecular data for cold tolerance of koa across the elevation gradient of the Hawaiian Islands provides insights into natural selection processes and may help to support guidelines for conservation and seed transfer in forest restoration efforts.
Mind over muscle? Time manipulation improves physical performance by slowing down the neuromuscular fatigue accumulation
Authors: Matta Pierre‐Marie , Glories Dorian , Alamia Andrea , Baurès Robin , Duclay Julien 
Published: November 2023

AbstractWhile physical performance has long been thought to be limited only by physiological factors, many experiments denote that psychological ones can also influence it. Specifically, the deception paradigm investigates the effect of psychological factors on performance by manipulating a psychological variable unbeknownst to the subjects. For example, during a physical exercise performed to failure, previous results revealed an improvement in performance (i.e., holding time) when the clock shown to the subjects was deceptively slowed down. However, the underlying neurophysiological changes supporting this performance improvement due to deceptive time manipulation remain unknown. Here, we addressed this issue by investigating from a neuromuscular perspective the effect of a deceptive clock manipulation on a single‐joint isometric task conducted to failure in 24 healthy participants (11 females). Neuromuscular fatigue was assessed by pre‐ to post‐exercise changes in quadriceps maximal voluntary torque (Tmax), voluntary activation level (VAL), and potentiated twitch (TTW). Our main results indicated a significant performance improvement when the clock was slowed down (Biased: 356 ± 118 s vs. Normal: 332 ± 112 s, p = .036) but, surprisingly, without any difference in the associated neuromuscular fatigue (p > .05 and BF < 0.3 for Tmax, VAL, and TTW between both sessions). Computational modeling showed that, when observed, the holding time improvement was explained by a neuromuscular fatigue accumulation based on subjective rather than actual time. These results support a psychological influence on neuromuscular processes and contribute significantly to the literature on the mind–body influence, by challenging our understanding of fatigue.
Effects of a telerehabilitation program and detraining on cardiorespiratory fitness in patients with post‐COVID‐19 sequelae: A randomized controlled trial
Authors: Pleguezuelos Eulogio , Del Carmen Amin , Moreno Eva , Miravitlles Marc , Serra Mateu , Garnacho‐Castaño Manuel V. 
Published: November 2023

AbstractBackgroundThis study aimed to evaluate the effects of a 15‐week telerehabilitation program and a detraining period on cardiorespiratory fitness and mechanical efficiency in patients with post‐COVID‐19 sequelae.Methods131 patients with post‐COVID‐19 sequelae were randomly assigned to one of two groups: patients who carried out the supervised telerehabilitation program (TRG, n = 66) and a control group (CG, n = 65). An incremental cardiopulmonary exercise testing (CPET) was performed on cycle ergometer to compare cardioventilatory responses between experimental groups.ResultsA significant increase in the CPET duration, peak power output, and mechanical efficiency was observed in TRG compared to CG after the telerehabilitation program (p ≤ 0.001). A significant increase in the CPET duration, peak power output, and mechanical efficiency was verified at 3 months compared to the pretest and after detraining in TRG (p < 0.001). A significant increase in peak oxygen uptake (V̇O2peak) was identified after the intervention and in the detraining period compared to the pretest in both experimental groups (p < 0.001). A higher ventilatory efficiency was observed after the telerehabilitation program (p = 0.021) than in pretest only in TRG.ConclusionsA 15‐week supervised home telerehabilitation program improved exercise capacity, power output, and mechanical efficiency in TRG compared to a CG. The telerehabilitation program was not more effective in improving V̇O2peak than the activities of the CG. However, ventilatory efficiency was improved only after the telerehabilitation program. The reported results after the detraining period highlight the need to maintain the rehabilitation program over time.
Extracting fracture properties from digital image and volume correlation displacement data: A review
Authors: Becker Thorsten H. 
Published: November 2023

AbstractThe advent of digital image and volume correlation has attracted wide use in fracture mechanics. The full‐field nature of digital image and volume correlation allows for the integration of computational fracture mechanics to analyse cracked samples quantitatively. This review provides a comprehensive overview of current methods used to extract fracture properties from full‐field displacement data. The term full‐field fracture mechanics is introduced to highlight the uniqueness of using inherently noisy experiential data to extract fracture properties. The review focuses on post‐processing‐based approaches rather than integrated approaches, as these have less limitations and are more commonly employed. There are four approaches that are discussed in extracting fracture properties from experimentally computed displacement data: field‐fitting, integral, crack‐opening and cohesive zone modelling approaches. This is further developed to discuss problems associated with using digital image and volume correlation to extract properties, including application examples.
Delineation of high‐resolution soil carbon management zones using digital soil mapping: A step towards mitigating climate change in the Northeastern Himalayas, India
Authors: Reza S. K. , Chattaraj S. , Mukhopadhyay S. , Daripa A. , Saha S. , Ray S. K. 
Published: November 2023

AbstractDelineation of carbon management zones (CMZs) by capturing geospatial distribution of soil organic carbon (SOC) stock down the profile is an effective strategy for precision agriculture and climate change mitigation. Satellite (Landsat OLI 8), terrain (SRTM 30 m DEM) and bioclimatic (WorldClim dataset) factors were used as covariables in this digital soil mapping approach. Depth harmonization using the quadratic spline method (equal‐area) was carried out prior to quantile regression forest (QRF) algorithm‐based modelling to estimate SOC stock at six standard soil depths (0–5, 5–15, 15–30, 30–60, 60–100 and 100–200 cm). Soil depth and SOC stock for the whole soil profile were used for the delineation of CMZs using fuzzy k‐means clustering. The predicted SOC stock, varied from 14.68 to 42.35 Mg ha−1 in the top layer (0–5 cm depth), while 17.91 to 36.88, 14.15 to 34.70, 12.55 to 35.59, 10.30 to 28.52 and 7.26 to 20.16 Mg ha−1 in the depths of 5–15, 15–30, 30–60, 60–100 and 100–200 cm, respectively. The QRF algorithm performed well in predicting SOC stock with high R2, which ranged from .67 to .83 for all the soil depths. To delineate three CMZs, modified partitioning entropy and the fuzzy performance index were used. In CMZ2, there was a significant increase in SOC stock, followed by CMZ1 and CMZ3. This zone (CMZ2) was located in the central region of the study area and was mostly covered by dense forest and perennial plantations (rubber). The CMZs provided the necessary foundation for the development of site‐specific carbon management techniques that can enhance ecosystem service and meet climate change mitigation goals.
A geographer's place matters: Reflections from a ‘local scholar’ and the politics of North/South knowledge production
Authors: Chann Sopheak 
Published: November 2023

AbstractThe most prominent and influential Geography literatures about the Global South are predominantly produced by scholars in the North and less so by intellectuals whose homes are located in the Global South—the ‘local scholars’. As a Cambodian scholar, I argue that the challenges of participating in collaborative, English language knowledge production derive not merely from skill disparities between international and ‘local’ academics, but also from constraints in finding the right platforms for research and academic expression. Constrained conditions for knowledge participation and expansion are rooted in a long history of colonialism in the Cambodian education system and the contemporary political economy of academia. Rather than directly engage with international intellectual and political discussions, in many cases, Cambodian scholars largely supply compelling stories—in the form of ethnographic evidence, data, images and affect to fuel theoretical debates taking place in the North. Beyond emphasising this well established inequity in the political economy of knowledge production, I contend that being ‘on the ground’ not only equips local scholars with contextual depths but also confines them to think and act locally.
Firm innovation under import competition from low‐wage countries
Authors: Chakravorty Ujjayant , Liu Runjuan , Tang Ruotao , Zhao Long 
Published: November 2023

AbstractIn recent years, manufacturing firms in the United States have faced increasing import competition from low‐wage countries, especially China. Does this competition hurt or help firm innovation? This paper studies the effect of the surge in imports from China on innovation by US manufacturing firms. We first propose a theoretical framework that generates an inverted‐U‐shaped curve of innovation on imitation, which is based on the endogenous price elasticity of demand for the product in a Cournot model. We then take the theoretical prediction to data on publicly listed firms in the Compustat data set from 1990 to 2010. We find consistent evidence that Chinese import competition had an inverted‐U effect on firm innovation, as measured by patent counts and citation‐weighted patents. Our result suggests that when import penetration is less than 60% it positively affects firm innovation, but when it is more than 60%, this positive effect is inverted. This inverted‐U relation persists when we instrument import competition in the United States by using Chinese import penetration in the United Kingdom and when we test the robustness of the results by including sector‐specific trends. We find that the inverted‐U relationship is steeper for firms in high‐tech industries.
Airy structures and deformations of curves in surfaces
Authors: Chaimanowong W. , Norbury P. , Swaddle M. , Tavakol M. 
Published: November 2023

AbstractAn embedded curve in a symplectic surface defines a smooth deformation space of nearby embedded curves. A key idea of Kontsevich and Soibelman is to equip the symplectic surface with a foliation in order to study the deformation space . The foliation, together with a vector space of meromorphic differentials on , endows an embedded curve with the structure of the initial data of topological recursion, which defines a collection of symmetric tensors on . Kontsevich and Soibelman define an Airy structure on to be a formal quadratic Lagrangian which leads to an alternative construction of the tensors of topological recursion. In this paper, we produce a formal series on which takes it values in , and use this to produce the Donagi–Markman cubic from a natural cubic tensor on , giving a generalisation of a result of Baraglia and Huang.
Reproductive justice in pediatric health care: a scoping review protocol
Authors: Arnold Leah , Palokas Michelle , Christian Robin 
Published: November 2023

Objective:
The objective of this scoping review is to identify the barriers and facilitators of reproductive justice in pediatric health care.

Introduction:
Reproductive justice is defined as the right to maintain personal bodily autonomy, to have or not have children, and to parent children in safe and sustainable communities. The reproductive justice framework is often applied to adult women in conventional care settings; however, the need for health care guided by the framework should extend to all females of reproductive age in all care settings, including pediatric settings.

Inclusion criteria:
This review will consider studies from 1994 to the present that report on the barriers and facilitators of reproductive justice in pediatric health care. Studies from any setting or geographic location will be included. This scoping review will include pediatric patients up to 21 years of age of any gender identity or sexual orientation who may birth a child, and their health care providers.

Methods:
Database searches will include CINAHL (EBSCOhost), MEDLINE (PubMed), Embase (Elsevier), and Web of Science Core Collection. Sources of unpublished studies and gray literature to be searched include MedNar and ProQuest Dissertation and Theses Science and Engineering Collection (ProQuest). The JBI methodology for scoping reviews will be followed. Data extracted will include details about the title, authors, year of publication, type of evidence, participants, context, and concept. The extracted data will be presented in diagrammatic or tabular format in a manner that aligns with the objective and questions of the scoping review.

Review registration:
Open Science Framework https://osf.io/d5vf9
Interkingdom and intrakingdom interactions in the microbiome of
Heterobasidion
fruiting body and associated decayed woody tissues
Authors: Ren Wenzi , Penttilä Reijo , Kasanen Risto , Asiegbu Fred O. 
Published: November 2023

ABSTRACT

The
Heterobasidion annosum
species complex is a major threat to the forest industry in the northern temperate regions of the world. The fungal and bacterial biota communities in
Heterobasidion
-infected trees have been extensively studied, but less is known about the interkingdom and intrakingdom interactions among the microbiome. The bacteria-fungi interkingdom analysis has revealed significant findings compared to the intrakingdom analysis in recent studies. In this study, we aimed to (i) unravel the contribution and development of the bacteria and other fungi in the
Heterobasidion
-infected wood decay process; (ii) uncover how environmental factors and the conifer pathogen drive the microbiome community structure and function changes; and (iii) identify the core microbiome during the
Heterobasidion
-mediated wood decay process. Internal transcribed spacer and 16S amplicon sequencing data from the
Heterobasidion
fruiting body and its associated woody tissue were applied in this analysis. Samples collected from managed forest and nature reserve forest were classified into four decay classes based on the extent of decay of the wood. Our result showed that bacteria and fungi have different abundances and activities in both study materials. The
Heterobasidion
ecological correlation network is conserved, especially in the fruiting body. The core microbiome defined in our analysis showed huge potential for the microbiome community’s functioning. A particular
Heterobasidion
Operational Taxonomic Units (OTU) had the most important impact on the community and disease development. Forest management has the biggest impact on the microbiome assembly, and the fungal community is more sensitive to environmental changes.

IMPORTANCE

We applied macro- (forest stand and forest management) and micro-scale (bacterial and fungal community) analyses for a better understanding of the
Heterobasidion
pathosystem and associated wood decay process. The core microbiome, as defined by hierarchy analysis and a consistent model, and environmental factors correlation with the community assembly were found to be novel.
Draft genome sequence of
Enterococcus
sp. SB12 isolated from artisanal cheese of the Carpathian
Authors: Mushynska Viktoriia , Roman Ivan , Tistechok Stepan , Slyvka Iryna , Tsisaryk Orysia , Gromyko Oleksandr , Shtapenko Oksana , Syrvatka Vasyl 
Published: November 2023

ABSTRACT

In this study, we present the draft genome sequence of the
Enterococcus
sp. strain SB12, which was isolated from artisanal cheese of the Carpathian region (Ukraine). The
de novo
assembly produced 64 contigs, with a total length of 2,514,601 bp. Phylogenetic analysis revealed its proximity to the
Enterococcus faecium
strains.
Pharmacokinetics and safety evaluation of intravenously administered
Pseudomonas
phage PA_LZ7 in a mouse model
Authors: Wang Si-yun , Tan Xin , Liu Zi-qiang , Ma Hui , Liu Tian-bin , Yang Yong-qing , Ying Yong , Gao Ru-yue , Zhang Dai-zhou , Ma Ying-fei , Chen Kai , Lin Lin , Jiang Zhi-huan , Yu Jia-lin 
Published: November 2023

ABSTRACT

Phage therapy has become one of the most promising alternatives to antibiotics as the surge of multi-drug-resistant (MDR) bacteria severely threatens global public health. The lack of a thorough understanding of pharmacokinetics (PK) and the safety study of phage has limited its clinical application. In this study, we aimed to evaluate the PK and safety of a lytic phage PA_LZ7 that infects MDR
Pseudomonas aeruginosa
using intravenous (IV) route in an uninfected immune-competent mice model. The active phage of PA_LZ7 exhibited an exponential decay in plasma at 2*10
8
(low dosage), 2*10
10
[medium dosage (MD)], and 2*10
11
PFU/kg [high dosage (HD)] after IV administration, and the phage titer dropped to ~4 log
10
PFU/mL over 24 h for all dosages. Phages primarily accumulated in the spleen at 1 h post-administration and gradually decreased in all dosages. The active phage titer in other organs decreased globally within 72 h as well. Plasma cytokines IL-6, IL-10, KC/GRO, and tumor necrosis factor-alpha sharply increased 1 h post-administration in mice of MD and HD groups and dropped to a normal range within 24 h. No obvious toxic effect was observed, except for the increased spleen weight and relative spleen weight in the MD and HD group and the slight lymphocytosis in the white pulp of the spleen in the HD group. In conclusion, PA_LZ7 possesses good PK properties and shows no obvious toxicity; it could be considered as a potent therapeutic candidate for the treatment of MDR
P. aeruginosa
infections in future phage therapy.

IMPORTANCE

Phage therapy is gaining traction as an alternative to antibiotics due to the rise of multi-drug-resistant (MDR) bacteria. This study assessed the pharmacokinetics and safety of PA_LZ7, a phage targeting MDR
Pseudomonas aeruginosa
, in mice. After intravenous administration, the phage showed an exponential decay in plasma and its concentration dropped significantly within 24 h for all dosage groups. Although there was a temporary increase in certain plasma cytokines and spleen weight at higher dosages, no significant toxicity was observed. Therefore, PA_LZ7 shows potential as an effective and safe candidate for future phage therapy against MDR
P. aeruginosa
infections.
Intrusion tip velocity controls the emplacement mechanism of sheet intrusions
Authors: Köpping Jonas , Cruden Alexander R. , Thiele Samuel T. , Magee Craig , Bunger Andrew 
Published: November 2023

Abstract
Space for intruding magma is created by elastic, viscous, and/or plastic deformation of host rocks. Such deformation impacts the geometries of igneous intrusions, particularly sills and dikes. For example, tapered intrusion tips indicate linear-elastic fracturing during emplacement, whereas fluidization of host rocks has been linked to development of elongate magma fingers with rounded tips. Although host rock fluidization has only been observed at the lateral tips of magma fingers, it is assumed to occur at their leading edges (frontal tips) and thereby control their propagation and geometry. Here, we present macro- and microstructural evidence of fluidized sedimentary host rock at the lateral tips of magma fingers emanating from the Shonkin Sag laccolith (Montana, western United States), and we explore whether fluidization could have occurred at their frontal tips. Specifically, we combine heat diffusion modeling and fracture tip velocity estimates to show that: (1) low intrusion tip velocities (≤10−5 m s−1) allow pore fluids ahead of the intrusion to reach temperatures sufficient to cause fluidization, but (2) when tip velocities are high (~0.01–1 m s−1), which is typical for many sheet intrusions, fluidization ahead of propagating tips is inhibited. Our results suggest that intrusion tip velocity (i.e., strain rate) is a first-order control on how rocks accommodate magma. Spatially and temporally varying velocities of lateral and frontal tips suggest that deformation mechanisms at these sites may be decoupled, meaning magma finger formation may not require host rock fluidization. It is thus critical to consider strain rate and three-dimensional intrusion geometry when inferring dominant magma emplacement mechanisms.