bluuebunny/crossref_metadata_2025_split huggingface dataset:
Stereotactic body radiotherapy (SBRT) re-irradiation for local failures following radical prostatectomy and post-operative radiotherapy
Authors: Majewski Wojciech , Miszczyk Marcin , Graupner Donata , Goc Bartłomiej , Goldner Gregor , Napieralska Aleksandra 
Published: December 2023

Abstract
Purpose
Local recurrences after radical prostatectomy (RP) and postoperative radiotherapy (RT) are challenging for salvage treatment. Retrospective analysis of own experiences with salvage re-irradiation was performed.

Methods
The study included all consecutive patients treated with salvage stereotactic body radiotherapy (sSBRT) for prostate bed recurrence following RP and postoperative RT at a single tertiary center between 2014 and 2021. Treatment toxicity defined as the occurrence of CTCAE grade ≥ 2 genito-urinary (GU) or gastro-intestinal (GI) adverse events (AEs) was assessed. A PSA response, biochemical control (BC) and overall survival (OS) were also evaluated.

Results
The study group included 32 patients with a median age of 68 years and a median follow-up of 41 months, treated with CyberKnife (53%) or Linac (47%) sSBRT. Total dose of 33.75–36.25 Gy in five fractions (72%) was applied in the majority of them. Approximately 19% patients reported grade ≥ 2 GU AEs both at baseline and at three months, and grade ≥ 2 GI toxicity increased from 0% at baseline to 6% at three months after sSBRT. There was some clinically relevant increase in late toxicity with 31% patients reporting late ≥ 2 GU, and 12.5% late ≥ 2 GI AEs. Two grade 3 AEs were recorded: recto-urinary fistulas. The majority of patients showed a PSA response (91% at one year post-sSBRT). The 3‑year BC was 40% and 3‑year OS was 87%.

Conclusions
Manageable toxicity profile and satisfactory biochemical response suggest that SBRT in patients with local recurrence following RP and postoperative RT might be a salvage option for selected patients.
Efficacy and safety of adalimumab in pediatric patients with Crohn’s disease: A systematic review and meta-analysis
Authors: Chen Bin , Zou Zhuan , Zhang Xiaoyan , Xiao Dongqiong , Li Xihong 
Published: December 2023

Abstract
Purpose
There is currently no curative treatment for childhood Crohn’s disease (CD). This meta-analysis aimed to validate the efficacy and safety of adalimumab (ADA) in pediatric patients with CD.

Materials and methods
We searched all relevant studies in the PubMed, Web of Science, Embase, and Cochrane Library databases. The primary outcomes were induction (≤ 12 weeks) and maintenance (up to 48 weeks) of remission and response. Secondary outcomes were severe adverse events and opportunistic infections to ADA. The Cochrane bias assessment tool was used to assess the risk of bias in randomized controlled trials. The methodological quality of the single-arm studies was assessed using the methodological index for non-randomized studies tool.

Results
Ten clinical trials involving a total of 885 patients were included. Results indicated that 59% (95% confidence interval [CI] 39–80%) of the subjects treated with ADA achieved induction of remission, and 60% (95% CI 35–86%) of the subjects treated with ADA achieved induction of response, 57% (95% CI 44–70%) achieved maintenance of remission, and 63% (95% CI 26–69%) achieved maintenance of response.

Conclusion
Current evidence indicates that ADA is effective in children and adolescents with CD and that adverse events vary but are usually not severe.

Systematic review registration
https://www.crd.york.ac.uk/prospero/, identifier CRD42023402199.
Phase III study of bilayer sustained-release tramadol tablets in patients with cancer pain: a double-blind parallel-group, non-inferiority study with immediate-release tramadol capsules as an active comparator
Authors: Shinkai Masaharu , Katsumata Noriyuki , Kawai Shinichi , Kuyama Shoichi , Sasaki Osamu , Yanagita Yasuhiro , Yoshida Minoru , Uneda Shima , Tsuji Yasushi , Harada Hidenori , Nishida Yasunori , Sakamoto Yasuhiro , Himeji Daisuke , Arioka Hitoshi , Sato Kazuhiro , Katsuki Ryo , Shomura Hiroki , Nakano Hideshi , Ohtani Hideaki , Sasaki Kazutaka , Adachi Takeshi 
Published: December 2023

Abstract
Purpose
We investigated whether twice-daily administration of a bilayer tablet formulation of tramadol (35% immediate-release [IR] and 65% sustained-release) is as effective as four-times-daily IR tramadol capsules for managing cancer pain.

Methods
This randomized, double-blind, double-dummy, active-comparator, non-inferiority study enrolled opioid-naïve patients using non-steroidal anti-inflammatory drugs or acetaminophen (paracetamol) to manage cancer pain and self-reported pain (mean value over 3 days ≥ 25 mm on a 100-mm visual analog scale [VAS]). Patients were randomized to either bilayer tablets or IR capsules for 14 days. The starting dose was 100 mg/day and could be escalated to 300 mg/day. The primary endpoint was the change in VAS (averaged over 3 days) for pain at rest from baseline to end of treatment/discontinuation.

Results
Overall, 251 patients were randomized. The baseline mean VAS at rest was 47.67 mm (range: 25.6–82.7 mm). In the full analysis set, the adjusted mean change in VAS was − 22.07 and − 19.08 mm in the bilayer tablet (n = 124) and IR capsule (n = 120) groups, respectively. The adjusted mean difference was − 2.99 mm (95% confidence interval [CI] − 7.96 to 1.99 mm). The upper 95% CI was less than the predefined non-inferiority margin of 7.5 mm. Other efficacy outcomes were similar in both groups. Adverse events were reported for 97/126 (77.0%) and 101/125 (80.8%) patients in the bilayer tablet and IR capsule groups, respectively.

Conclusion
Twice-daily administration of bilayer tramadol tablets was as effective as four-times-daily administration of IR capsules regarding the improvement in pain VAS, with comparable safety outcomes.

Clinical trial registration
JapicCTI-184143/jRCT2080224082 (October 5, 2018).
Enhanced sensing performance of carboxymethyl cellulose sodium to hydrogen sulphide gas and methylene blue dye by constructing CuO@ZnO core/shell heterostructure: A DFT/TD-DFT study
Authors: Badry Rania , Nada Nadra , El-Nahass Mahmoud M. , Elhaes Hanan , Ibrahim Medhat A. 
Published: December 2023

AbstractAnthropogenic air and water pollution are two of the world's most serious public health threats, causing around 9 million fatalities each year. Accordingly, CuO, ZnO, and CuO@ZnO core/shell structures were optimized utilizing the time-dependent density functional theory (TD-DFT) method to study the effect of CuO@ZnO core/shell on the sensitivity of carboxymethyl cellulose sodium (CMC). Absorption spectra and optical band gap (Eg) have been investigated utilizing the TD-DFT method. The calculated Eg values for CuO and ZnO equal 1.23 and 3.29 eV, respectively, which agree well with those reported in the literature. The effects of H2S gas and methylene blue dye (MB) adsorption on the electronic characteristics of dimer CMC /CuO@ZnO structures were investigated in terms of TDM, HOMO/LUMO energy, and molecular electrostatic potential (MESP). The TDM in dimer CMC/CuO@ZnO structure was increased to 72.152 and 67.606 Debye, while ΔE was reduced by 6.42% and 82.57% due to the adsorption of H2S and MB dye, respectively. This means that it has a faster response to MB than to H2S. Additionally, MESP confirms the increased reactivity of dimer CMC/CuO@ZnO due to the adsorption process. As a result, dimer CMC/CuO@ZnO structures appear to be attractive candidates for H2S and MB dye sensing applications.
Effect mechanism investigation of herb-partitioned moxibustion on relieving colon inflammation in Crohn disease rats based on neutrophil extracellular traps
Authors: Lu Chi , Xu Jing , Lu Yuan , Wu Luyi , Bao Chunhui , Ma Zhe , Zhong Rui , Wang Zhaoqin , Sun Kexin , Zheng Handan , Weng Zhijun , Huang Yan , Wu Huangan 
Published: December 2023

Abstract
Objective
To explore the mechanism of herb-partitioned moxibustion in relieving rat intestinal inflammation by focusing on the neutrophil extracellular traps (NETs) in Crohn disease (CD) development.

Methods
Rats were randomly divided into a normal group, a model group, a herb-partitioned moxibustion group, and a mesalazine group. The CD rat model was prepared with 2,4,6-trinitrobenzene sulfonic acid except for rats in the normal group. Rats in the normal group and model group did not receive any treatment but had the same fixation as the other groups. Rats in the herb-partitioned moxibustion group received herb-partitioned moxibustion at Qihai (CV6) and bilateral Tianshu (ST25). Rats in the mesalazine group received intragastric administration of mesalazine enteric-coated tablets. The general situation of rats in each group was recorded, and the histopathological changes in the colon were observed and scored by hematoxylin-eosin staining. The serum concentrations of NETs DNA (NETs-DNA), neutrophil elastase (NE)-DNA, and myeloperoxidase (MPO)-DNA were detected by ABC enzyme-linked immunosorbent assay, and the citrullinated histone 3 (citH3), MPO, and NE protein and mRNA expression levels in rat colon tissue were observed by immunofluorescence and real-time quantitative polymerase chain reaction.

Results
Compared with the normal group, the mucosal ulcer reached the muscularis, the epithelium was incomplete, the goblet cells decreased obviously with significant inflammatory cell infiltration in the colon; the colonic mucosa damage index (CMDI) score increased significantly (P<0.01); the serum NETs-DNA, NE-DNA, and MPO-DNA concentrations increased (P<0.05); the NE, citH3, and MPO protein and mRNA expression in the colonic tissues increased significantly in the model group (P<0.01 or P<0.05). Compared with the model group, the mucosal epithelium in the herb-partitioned moxibustion group and the mesalazine group was repaired and the goblet cells increased with a few infiltrating inflammatory cells in the colon; the CMDI score decreased (P<0.01); the serum NETs-DNA, NE-DNA, and MPO-DNA concentrations decreased (P<0.05); the NE, citH3, and MPO protein and mRNA expression in the colonic tissues was down-regulated (P<0.01 or P<0.05).

Conclusion
Herb-partitioned moxibustion reduced the serum NETs complex and inhibited the protein and mRNA expression of NETs complex in the colon tissue, which may be one mechanism of herb-partitioned moxibustion in relieving colon mucosal inflammation in CD.
Combined Effects of Yellow Mealworm (Tenebrio molitor) and Saccharomyces cerevisiae on the Growth Performance, Feed Utilization Intestinal Health, and Blood Biomarkers of Nile Tilapia (Oreochromis niloticus) Fed Fish Meal-Free Diets
Authors: Anany Ehab M. , Ibrahim Mostafa A. , El-Razek Ibrahim M. Abd , El-Nabawy El-Said M. , Amer Asem A. , Zaineldin Amr I. , Gewaily Mahmoud S. , Dawood Mahmoud A. O. 
Published: December 2023

AbstractAquafeed quality is the most critical factor for aquaculture sustainability. However, limitations of traditional feed ingredients such as fishmeal (FM) need alternative strategies to ensure the nutritional requirements for aquatic animals. In this trial, four test diets were formulated (2 × 2 factorial design), where FM was incorporated in two diets at 10% with or without Saccharomyces cerevisiae (SC) at 1 g/kg. At the same time, FM was replaced with yellow mealworm (Tenebrio molitor) meal (TM) with or without SC at 1 g/kg. The growth performance indices (final weight, weight gain, and SGR), and the feed utilization indices (FCR and PER) were markedly affected by the protein source (FM or TM) and dietary SC (P < 0.05). The protein source (FM or TM) significantly (P < 0.05) affected the whole-body protein and lipid contents, while the moisture and ash contents were unaffected (P > 0.05) by TM or SC. The growth of the intestinal villi showed a marked increase in both height and branching in the treated groups with SC along the whole length of the intestine. Furthermore, the immune cell infiltration was prominent near the intestinal crypts of the middle intestinal segments in the supplemented groups by SC. Dietary TM and SC revealed improved hepatic parenchyma in the liver tissue better than other groups. The hematological indices, including hemoglobulin, hematocrit, red blood cells, and white blood cells, were markedly affected by dietary SC (P < 0.05). The lysozyme activity and phagocytic index were markedly affected by dietary SC, while phagocytic activity was affected by dietary TM (P < 0.05). The catalase, glutathione peroxidase, and malondialdehyde were markedly affected by the interaction between dietary protein source and SC, while superoxide dismutase was affected by dietary SC (P < 0.05). In conclusion, adding SC could enhance the utilization of TM by Nile tilapia with positive effects on the intestinal and liver histological features and the immune and antioxidative responses.
Analyzing environmental flow supply in the semi-arid area through integrating drought analysis and optimal operation of reservoir
Authors: Sedighkia Mahdi , Datta Bithin 
Published: December 2023

AbstractThis study proposes a novel form of environmental reservoir operation through integrating environmental flow supply, drought analysis, and evolutionary optimization. This study demonstrates that simultaneous supply of downstream environmental flow of reservoir as well as water demand is challenging in the semi-arid area especially in dry years. In this study, water supply and environmental flow supply were 40% and 30% in the droughts, respectively. Moreover, mean errors of supplying water demand as well as environmental flow in dry years were 6 and 9 m3/s, respectively. Hence, these results highlight that ecological stresses of the downstream aquatic habitats as well as water supply loss are considerably escalated in dry years, which implies even using environmental optimal operation is not able to protect downstream aquatic habitats properly in the severe droughts. Moreover, available storage in reservoir will be remarkably reduced (averagely more than 30×106 m3 compared with optimal storage equal to 70×106 m3), which implies strategic storage of reservoir might be threatened. Among used evolutionary algorithms, particle swarm optimization (PSO) was selected as the best algorithm for solving the novel proposed objective function. The significance of this study is to propose a novel objective function to optimize reservoir operation in which environmental flow supply is directly addressed and integrated with drought analysis. This novel form of optimization system can overcome uncertainties of the conventional objective function due to considering environmental flow in the objective function as well as drought analysis in the context of reservoir operation especially applicable in semi-arid areas. The results indicate that using either other water resources for water supply or reducing water demand is the only solution for managing downstream ecological impacts of the river ecosystem. In other words, the results highlighted that replanning of water resources in the study area is necessary. Replacing the conventional optimization system for reservoir operation in the semi-arid area with proposed optimization system is recommendable to minimize the negotiations between stakeholders and environmental managers.
Evaluation of the water conservation function in the Ili River Delta of Central Asia based on the InVEST model
Authors: Cao Yijie , Ma Yonggang , Bao Anming , Chang Cun , Liu Tie 
Published: December 2023

AbstractThe Ili River Delta (IRD) is an ecological security barrier for the Lake Balkhash and an important water conservation area in Central Asia. In this study, we selected the IRD as a typical research area, and simulated the water yield and water conservation from 1975 to 2020 using the water yield module of the Integrated Valuation of Ecosystem Services and Tradeoffs (InVEST) model. We further analyzed the temporal and spatial variations in the water yield and water conservation in the IRD from 1975 to 2020, and investigated the main driving factors (precipitation, potential evapotranspiration, land use/land cover change, and inflow from the Ili River) of the water conservation variation based on the linear regression, piecewise linear regression, and Pearson’s correlation coefficient analyses. The results indicated that from 1975 to 2020, the water yield and water conservation in the IRD showed a decreasing trend, and the spatial distribution pattern was “high in the east and low in the west”; overall, the water conservation of all land use types decreased slightly. The water conservation volume of grassland was the most reduced, although the area of grassland increased owing to the increased inflow from the Ili River. At the same time, the increased inflow has led to the expansion of wetland areas, the improvement of vegetation growth, and the increase of regional evapotranspiration, thus resulting in an overall reduction in the water conservation. The water conservation depth and precipitation had similar spatial distribution patterns; the change in climate factors was the main reason for the decline in the water conservation function in the delta. The reservoir in the upper reaches of the IRD regulated runoff into the Lake Balkhash, promoted vegetation restoration, and had a positive effect on the water conservation; however, this positive effect cannot offset the negative effect of enhanced evapotranspiration. These results provide a reference for the rational allocation of water resources and ecosystem protection in the IRD.
StockTwits classified sentiment and stock returns
Authors: Divernois Marc-Aurèle , Filipović Damir 
Published: December 2023

AbstractWe classify the sentiment of a large sample of StockTwits messages as bullish, bearish or neutral, and create a stock-aggregate daily sentiment polarity measure. Polarity is positively associated with contemporaneous stock returns. On average, polarity is not able to predict next-day stock returns. But when we condition on specific events, defined as sudden peaks of message volume, polarity has predictive power on abnormal returns. Polarity-sorted portfolios illustrate the economic relevance of our sentiment measure.
Bicoherence Analysis of Oxygen Ion Cyclotron Harmonic Waves Observed by Van Allen Probes
Authors: Wang Yan , Liu Kaijun , Yao Fei , Xiong Ying 
Published: December 2023

AbstractBicoherence analysis is statistically performed for the oxygen ion cyclotron harmonic (OCH) waves observed by Van Allen Probes. While OCH waves and so‐called electromagnetic ion cyclotron harmonics have indistinguishable spectral characteristics in observation, they are believed to be excited by different mechanisms with the latter being suggested to arise from nonlinear wave‐wave coupling. Our result reveals that most of the OCH wave events have small bicoherence indices, so they are unlikely excited by wave‐wave coupling. The result is not much affected by the parameter choice in the bicoherence analysis, although increasing the subinterval length and/or reducing the subinterval overlap increases the chance of getting large bicoherence index values. Furthermore, the examination of two special events with large bicoherence indices shows that the observed phase relationship among different wave components does not align with the expectation from wave‐wave coupling. The events cannot be convincingly confirmed to be generated through wave‐wave coupling.
Validation of Two Newly Developed Albedo Schemes Based on the Observations Over the Region With Evergreen Broadleaved Forest in Southern China
Authors: Wang Huan , Wei Zhigang , Huang Anning , Li Xianru , Ma Li , Guo Shitong 
Published: December 2023

AbstractExisting land surface models still have large error in the simulation of surface albedo. At present, introducing the influence of meteorological factors into the albedo parameterization scheme is an effective way to improve the albedo simulation. However, the improvement of the vegetation canopy surface albedo parameterization scheme is still insufficient. Therefore, based on the radiation and meteorological observation data during 1 November 2015–30 April 2018 from a land‐atmosphere interaction observation tower in a typical secondary evergreen broadleaved forest in Southern China, this study firstly analyzed the influencing factors of canopy surface albedo. It was found that the solar elevation angle and air relative humidity are two key factors influencing the canopy surface albedo, and the impact of the solar elevation angle on canopy surface albedo is not exactly the same on diurnal and seasonal scales. Then, two new canopy surface albedo parameterization schemes of additive form and multiplicative form were proposed and introduced into CLM5 model for single point simulation. Results show that the adoption of newly developed canopy surface albedo parameterization schemes can improve the simulation of diurnal and seasonal variations of albedo and reduce the overestimation of the simulation of near‐infrared radiation albedo and visible radiation albedo in the CLM5 model, then significantly reduce the root mean square errors of reflected solar radiation and net radiation simulation.
Hydrodynamic and Morphological Adaptation of Two Consecutive Sharp Bends of the Middle Yangtze River to Upstream Damming
Authors: Liu Xin , Xia Junqiang , Deng Shanshan , Zhou Meirong , Mao Beiping , Blanckaert Koen 
Published: December 2023

AbstractIt remains an open question how the hydrodynamics and morphology in sharp meander bends adapt to the changes in flow and sediment conditions induced by upstream damming. This study reports a comprehensive investigation into the morphological changes, patterns of mean and secondary flows and sediment transport around two consecutive sharp bends in the Middle Yangtze River (MYR), and explains these changes from the viewpoint of flow‐sediment transport‐morphology interaction based on field measurements. With the Three Gorges Project operation, the MYR suffered a remarkable channel degradation due to a sudden decrease of incoming sediment discharge. The point bars were removed, and outer‐bank benches (OBB) formed upstream of the bend apices, which resulted in quite different flow and sediment transport patterns in the bends. The highest velocity zones and center‐region cells of secondary flow were more toward the inner bank due to the lack of point bars, and the outward migration of momentum was delayed. Flow recirculation zones were observed over the OBBs, covering 12%–58% of the channel width. The transport rates of suspended load accounted for 98% of the total sediment load, and the outward shift of the highest transport rate zone was confined by the OBBs, which reduced the effective width of sediment transport. These changes in flow and sediment transport re‐inforced the morphological changes around the sharp bends: the velocity redistribution and evolution of scour factor lagged more behind planform curvature, which further promoted the erosion of point bars and the development of OBB.