bluuebunny/crossref_metadata_2025_split huggingface dataset:
THERANOVA-LIM: Optimizing the city hospital link to support patients on oral anticancer drugs
Authors: Boucheteil Marion , Leobon Sophie , Baffert Kim-Arthur , Darbas Tiffany , Peyramaure Clémentine , brun-Ly Valérie Le , Pestre Julia , Venat Laurence , Thuillier Frédéric , HUET Soline , Jost Jeremy , Touati Mohamed , DELUCHE Elise 
Published: January 2024

Abstract

Purpose: Recent developments in oral chemotherapy and targeted therapies have radically changed the way in which cancer patients are managed. Ambulatory care is now common, associated with the development of organizations that foster, secure home treatments, and reinforce the city hospital link.
Methods: THERANOVA-LIM (NCT04931329), a prospective, interventional study, assessed the satisfaction of healthcare professionals and patients who benefited from improved access to information on appropriate drug use imparted by a drug vigilance card or a prescription with a QR code.
Results: Initially, an e-questionnaire was used to explore the practices and expectations of retail pharmacists; only 40% stated that they felt comfortable when managing patients on oral therapy. A total of 128 patients were included in the study, 55 in a “medication vigilance card” group and 73 in a “prescription with QR code” group. Patients were satisfied with the new systems and with the simplicity afforded by both the card and the prescription (p = 0.8). Similarly, 93.2% of professionals were satisfied with the new system. However, they felt that the prescription with a QR code was of greater assistance than the drug vigilance card (p = 0.02). There was no significant between-group difference in compliance (p = 0.3595)
Conclusion: The two systems improved the management of patients on oral chemotherapy; the QR-coded prescription was optimal. The fact that both patients and healthcare professionals were satisfied encourages us to extend the innovations and evaluate them further.
Trial Registration Number and the date of registration: ClinicalTrials.gov, NCT04931329. 2021-05-10
Self-Reported Confidence of DPT Students in Assessing and Treating Different Body Regions Within Musculoskeletal Physical Therapy Practice
Authors: Lowe Scott , Wiley Jennifer 
Published: January 2024

Abstract
Introduction
This study examined Doctorate of Physical Therapy (DPT) students' self-reported confidence in assessing and treating musculoskeletal (MSK) conditions based on body regions. We hypothesized that there would be identifiable differences in self-perceived confidence across the different body regions. Most literature assessing DPT students' readiness for clinical practice has come from the perspective of educators and clinicians, whereas student perspectives have not been reported.
Methods:
The study is a descriptive, observational online survey. Participants were final-year DPT students in the United States. Participants rated their comfort level in assessing and treating patients with MSK complaints, both in general and specifically for each body region. Additionally, we asked for written comments to elaborate on the answers provided.
Results:
A total of 148 eligible responses were collected. The respondents had the highest self-reported confidence in the assessment and treatment of the knee by a significant margin, with a mean score of 4.24 out of 5. Hip and Lumbar spine were the next highest-scored areas.
The Wrist and Hand had the lowest reported confidence at 2.63. Thoracic spine and pelvis were the second lowest scores. Qualitative data included multiple mentions of the distal upper extremity being deemphasized and the impact of COVID-19 on their preparedness for practice.
Conclusion:
Lower average confidence in the assessment and treatment of the wrist and hand, thoracic spine, and pelvis indicate that modification of existing methods of teaching these topics should be considered.
Trends identified in this research provide actionable data for both didactic and clinical educators. Furthermore, this data provides topics of discussion for those mentoring and educating new graduate clinicians. With these findings in mind, educators should consider reviewing instructional strategies in areas which showed the least perceived preparedness.
Trial Registration: Not applicable
Features of fume distribution in the working zone during arc welding operations with various covered electrodes
Authors: Kirichenko K. Yu. , Stratidakis A. K. , Kholodov A. S. , Karakitsios S. , Mezhuev Y. O. , Papadopoulou P. , Rogulin R. S. , Vakhnuk I. A. , Zakharenko A. M. , Gridasov A. V. , Karabtsov A. A. , Il'yashchenko D. P. , Tsatsakis A. , Sarigiannis D. A. , Golokhvast K. S. 
Published: January 2024

Abstract
Particles in welding fumes (WFs) generated through arc welding operations pose serious health concerns to the welders through their exposure to heavy metals. In this study, the influence of different covering types of industrial electrodes (rutile, basic, acid, rutile-cellulose) on the particle size distribution, morphology, and elemental composition of particles of welding fumes was investigated. Quantitative analysis was conducted in order to determine the distribution of particles with diameters of 10μm, or less, (PM10 fraction) of the WFs within the workplace, followed by the comparison of the results with the current international normative documents on the maximum permissible concentration of the PM10 fraction in the working zone air. The most hazardous types of electrode coverings were determined based on the dispersion, chemical composition, and concentration of formed particles of the PM10 fraction in space and time. The dependence of the particle size distribution time of the WFs in the working zone was identified for a basic covered industrial electrode. The maximum sizes of WF particles were reported for operations held at 100 A with electrodes having the rutile-cellulose type of covering, and at 150 A having the basic type of covering. A concentration of 0.05 mg/m3 for the PM10 fraction of WFs in the workplace was achieved after 1 hour of the welding machine operation at a current equal to 100 A. Thus, the results of the characterization of WFs demonstrate the risks of the arc welding process to human health and stress the need for their control and mitigation. According to the results of the study, a proportional relationship between the average particle diameter and the WF particle distribution period in the workplace has been demonstrated, which has been particularly evident from the height of the WF particles. 3D modeling of the dispersion of WF particles during welding arc operations proved to be a suitable method for their characterization.
Evaluation and impact factors of cobalt resource industrial international competitiveness: A perspective based on trade networks
Authors: Xu Ligang , Guo Xiang , Xu Meijuan , Jia Yanglei , Zhong Zhengfang 
Published: January 2024

Abstract
In recent years, with the development of the new energy industry, the demand for cobalt as a raw material for power batteries has been increasing. However, China itself has a shortage of cobalt resources. Therefore, overcoming poor resource conditions and enhancing the international competitiveness of the cobalt industry have become urgent issues. This paper is based on global trade data on cobalt resources from 2007 to 2020. A panel regression model is constructed from the perspective of trade networks, and Entropy-Topsis is used to construct a comprehensive evaluation index system for the international competitiveness of critical nonferrous metals. This study empirically examines the impact of the trade network characteristics of cobalt resources on international competitiveness, assigns practical significance to trade network characteristic indicators, and analyses the overall competitiveness changes in the global cobalt industry chain and its upstream, midstream, and downstream sectors. The research findings reveal the following key points: (1) In recent years, the competitive focus of the cobalt industry chain in various countries has shifted from upstream and midstream to midstream and downstream, with increasingly fierce trade competition downstream, gradually tilting toward countries such as South Korea, Japan, and China. (2) Cobalt trade competition, which was initially characterized by competition among multiple countries, has gradually become more centralized and stable, with differences in the competitiveness of various countries occurring at different stages of the cobalt industry chain. (3) Network centrality and network heterogeneity both have a significant promoting effect on the international competitiveness of the industry, while network connectivity has a significant inhibitory effect on the improvement of international competitiveness.
Resting-State EEG Signature of Early Consciousness Recovery in Comatose Traumatic Brain Injury Patients
Authors: Alkhachroum Ayham , Flo Emilia , Manolovitz Brian , Stradecki-Cohan Holly Marie , Shammassian Berje , Bass Danielle , Aklepi Gabriela , Monexe Esther , Ghamasaee Pardis , Sobczak Evie , Samano Daniel , Saavedra Ana Bolaños , Massad Nina , Kottapally Mohan , Merenda Amedeo , Cordeiro Joacir Graciolli , Jagid Jonathan , Kanner Andres M. , Rundek Tatjana , O'Phelan Kristine , Claassen Jan , Sitt Jacobo 
Published: January 2024

Abstract

Background
Resting-state electroencephalogram (rsEEG) is usually obtained to assess seizures in comatose patients with traumatic brain injury (TBI) patients. We aim to investigate rsEEG measures and their prediction of early recovery of consciousness in comatose TBI patients.
Methods
This is a retrospective study of comatose TBI patients who were admitted to a level-1 trauma center (10/2013-1/2022). Demographics, basic clinical data, imaging characteristics, and EEG data were collected. We calculated using 10-minute rsEEGs: power spectral density (PSD), permutation entropy (PE – complexity measure), weighted symbolic-mutual-information (wSMI – global information sharing measure), Kolmogorov complexity (Kolcom – complexity measure), and heart-evoked potentials (HEP - the averaged EEG signal relative to the corresponding QRS complex on electrocardiogram). We evaluated the prediction of consciousness recovery before hospital discharge using clinical, imaging, rsEEG data via Support Vector Machine with a linear kernel (SVM).
Results
We studied 113 (out of 134, 84%) patients with rsEEGs. A total of 73 (65%) patients recovered consciousness before discharge. Patients who recovered consciousness were younger (40 vs. 50, p .01). Patients who recovered consciousness had higher Kolcom (U = 1688, p = 0.01,), increased beta power (U = 1652 p = 0.003), with higher variability across channels ( U = 1534, p = 0.034), and epochs (U = 1711, p = 0.004), lower delta power (U = 981, p = 0.04) and showed higher connectivity across time and channels as measured by wSMI in the theta band (U = 1636, p = .026, U = 1639, p = 0.024) than those who didn’t recover. The ROC-AUC improved from 0.66 (using age, motor response, pupils’ reactivity, and CT Marshall classification) to 0.69 (p < 0.001) when adding rsEEG measures.
Conclusion
We describe the rsEEG EEG signature in recovery of consciousness prior to discharge in comatose TBI patients. Resting-state EEG measures improved prediction beyond the clinical and imaging data.
Effect of heat treatment at mild temperatures on the composition and physico-chemical properties of Scots pine resin
Authors: Sansonetti Errj , Cirule Dace , Kuka Edgars , Andersone Ingeborga , Andersons Bruno , Meile Kristine , Vevere Laima 
Published: January 2024

Abstract

A major function of resin in trees is to provide defense against external attacks by releasing the resin flow on the attacked or damaged area. Nonetheless, the leakage of the resin on the surface can have a negative aesthetic and economic impact on wood material. The aim of this study was to investigate how heat treatment affects the chemo-physical properties of the resin of Pinus sylvestris L. in order to hinder the exudation on wood surface during service. To reduce the fluidity of the resin, it is necessary to remove the volatile fraction of resin, and several studies have been carried out in this direction, providing useful information about this process. The results from thermal analyses (DSC, TGA) confirmed that heat treatment at mild temperatures, 80 °C, 90 °C and 100 °C, respectively, had a positive effect on increasing the glass transition temperature Tg and showed a good correlation between the Tg and the residual volatile content. FTIR spectroscopy, before and after heat treatment, did not show major changes in chemical structures, whilst UHPLC-DAD-MS analysis revealed significant differences for the ratios of compounds, which are the result of possible chemical reactions, such as dehydrogenation, oxidation and isomerization.
Soil carbon and nitrogen dynamics under conservation agriculture components for direct seeded rice-green gram system
Authors: Patra Gayatri , Chatterjee Dibyendu , Moharana Khitish Chandra , Nayak Bitish Kumar , Tripathi Rahul , Shahid Mohammad , Pani Dipti Ranjan , Das Saikat Ranjan , Panda Bipin Bihari , Munda Sushmita , Kumar Upendra , Nayak Amaresh Kumar 
Published: January 2024

Abstract
Continuous monocropping of puddled rice in Eastern India has decreased crop productivity and contributed to the deterioration of soil structure. To address this issue, conservation agriculture (CA) is being developed as a method to promote sustainability of the rice-based cropping system in eastern India. The study was conducted with the objectives to evaluate the influence of CA components on C and N mineralization and to study the impact of CA on the soil enzymes, C and N fractions. At the research farm of ICAR National Bureau of Plant Genetic Resources, Cuttack, a study was conducted using components of conservation agriculture in different combinations. The study included the effects of different components of CA, such as reduced tillage (T), addition of crop residues (R), and crop diversification (D) both alone and in combinations. Standard methods were used to determine carbon (C) and nitrogen (N) fractions, mineralization, and soil enzyme activities. Results showed that the addition of residue and crop diversification components (crop residues, crop residues with reduced tillage, crop residues with diversification and crop residues with reduced tillage and diversification) had higher CO2-C levels. Carbon mineralization in terms of mean cumulative CO2-C (mg CO2-C kg-1) fit well with first-order kinetics (R2=0.97-0.99), suggesting that degradation is concentration-dependent. Potentially mineralizable N (N0) content ranged from 191.27 to 219.53 kg ha-1, with the highest value in diversification (D). It showed the highest dehydrogenase activity and nitrate reductase activity, while residue addition in rice-green gram system (RD) showed the highest fluorescein di-acetate and β-glucosidase activities. At all growth stages, diversification (D) had the highest values for microbial biomass C, ammonium N and nitrate N. Correlation study shows a positive interaction between carbon and nitrogen fractions with soil enzymatic activities. It can be concluded that the influence of crop diversification (component D) and residue addition (component R) were more effective in C and N mineralization, fractions and soil enzyme activities than the other component of CA. The beneficial effect of incorporating residues is even more effective when it is combined with crop diversification. The combination of some of the components of CA are as good as complete CA in C and N mineralization, fractions and soil enzyme activities for rice-green gram cropping system.
How can we support research participants who stop taking part? Communications guidance developed through public-researcher collaboration
Authors: Cragg William J , Bishop Liam , Gilberts Rachael , Gregg Michael , Lowdon Terry , Mancini Mary , de Barros Clara Martins , Wheatstone Pete 
Published: January 2024

Abstract

Background
Research study participants can stop taking part early, in various circumstances. Sometimes this experience can be stressful. Providing participants with the information they want or need when they stop could improve participants' experiences, and may benefit individual studies' objectives and research in general. A group of public contributors and researchers at the Clinical Trials Research Unit, University of Leeds, aimed to develop a communication template and researcher guidance. This would address how to provide information sensitively to participants stopping or significantly reducing their level of participation.
Methods
The project lead conducted a literature review to identify relevant prior evidence and derive a list of potential information topics to communicate to participants who stop taking part. The topic list was reviewed by research professionals and public contributors before finalisation. Further public contributors were identified from a range of networks. The contributors formed a 'development group', to work on the detail of the planned resources, and a larger 'review group' to review the draft output before finalisation. The involvement was planned so that the development group could shape the direction and pace of the work.
Results
The literature review identified 413 relevant reports, resulting in 94 information topics. The review suggested that this issue has not been well explored previously. Some evidence suggested early-stopping participants are sometimes excluded from important communications (such as study results) without clear justification. The development group agreed early to focus on guidance with reusable examples rather than a template. We took time to explore different perspectives and made decisions by informal consensus. Review group feedback was broadly positive but highlighted the need to improve resource navigability, leading to its final online form.
Conclusions
We co-developed a resource to provide support to research participants who stop taking part. A strength of this work is that several of the public contributors have direct lived experience of stopping research participation. We encourage others to review the resource and consider how they support these participants in their studies. Our work highlights the value of researchers and participants working together, including on complex and ethically challenging topics.
Close follow-up of early breast cancer patients in Greece. A single-center survey based on a one-to-one interview with questions. A cross-sectional descriptive study
Authors: Papadopoulos Lazaros , Katsimi Margarita , Fokianou Anna , Maniatis Dimitrios , Ntasiou Panagiota , Alevizou Romina , Pavlakis Emmanouil , Kontogianni Panagiota , Selmani Joninda , Kechagioglou Ioannis , Iosifidou Christina , Eleftheriadou Stavroula-Dafne , Fostira Florentia , Filippidou Sofia , Xepapadakis Grigorios 
Published: January 2024

Abstract
Purpose
Follow-up protocols for breast cancer patients differ among different countries and health systems. Our institutional guidelines suggest close follow-up with a physical exam followed by a breast ultrasound every 6 months and mammography and Dexa scans annually. Imaging of the abdomen, pelvis, and brain is based on the physician's choice. We aimed to estimate breast cancer patients’ preferences in Greece concerning their follow-up care program, given the information that no differences were detected in overall survival in patients who followed an intensive program compared to patients who followed a less frequent program.
Materials and Methods
In total, 283 non-metastatic breast cancer patients were asked on an individual basis how they found their follow-up protocol and if they wished changes to be made. A 20-question survey was used.
Results
In total, 22.7% of participants preferred less frequent follow-up (PLFF) care. Overall, 88.3% of patients did not consider the number of tests excessive, and 77.3% of participants did not prefer to be tested less frequently. The percentage of PLFF is higher when patients have undergone surgery recently and decreases with time from the surgery (-0.124, p < 0.05). PLFF is also negatively associated with feeling secure as a result of frequent examination (-1.86, p < 0.01). In contrast, a positive association with PLFF (0.883, p < 0.05) was observed among patients who did not receive chemotherapy.
Conclusion
Our findings highlight that patients’ reported follow-up care preferences should be considered when planning the follow-up protocols in the healthcare system.
Senecavirus cetus a novel picornavirus isolated from cetaceans represents a major host switching to the marine environment
Authors: Vernygora Oksana , Sullivan Daniel , Nielsen Ole , Huntington Kathleen Burek , Rouse Natalie , Popov Vsevolod , Lung Oliver 
Published: January 2024

Abstract

Senecavirus A(SVA), an emerging virus that causes vesicular disease in swine, was, until recently, the only member of theSenecavirusgenus (Picornaviridae). Here, we report the isolation and complete genome sequence of two isolates of cetacean picornavirus 1 (Senecavirus cetus), a novel picornavirus species of theSenecavirusgenus from dead stranded cetaceans from Alaska. One isolate was from a harbor porpoise stranded in 2017, and another from a beluga whale, stranded in 2019. Whole-genome sequencing ofSenecavirus cetusstrains showed genome-wide nucleotide identity of 98.8% and a genome size of 7455 nucleotides. TheSenecavirus cetusgenomes are most similar to SVA with a 58.3% genome-wide pairwise nucleotide identity. Infection of eleven available cell lines from terrestrial and aquatic animals showed that beluga and sheep cells were susceptible to infection bySenecavirus cetus. Phylogenetic and ancestral state reconstruction analyses supported the novel virus being a member of theSenecavirusgenus and provided the first evidence ofSenecavirus-like picornavirus infecting marine mammals and likely descending from a terrestrial host ancestor. These discoveries provided important information on the evolutionary relationships and taxonomy of picornaviruses and increased our understanding of the genomic characteristics and potential host range ofSenecavirus cetus.
Optimization of enzymatic transesterification of acid oils for biodiesel production using a low-cost lipase: the effect of transesterification conditions and the synergy of lipases with different regioselectivity
Authors: Moschona Alexandra , Spanou Androniki , Pavlidis Ioannis V. , Karabelas Anastasios J. , Patsios Sotiris I. 
Published: January 2024

Abstract

This study describes the enzymatic production of 2nd generation biodiesel using low-quality acid oil as a substrate. Biolipasa-R, a commercially available and low-cost lipase, was employed for enzymatic transesterification. Response surface methodology was applied to optimize the enzymatic transesterification process. The optimal conditions for biodiesel production, which comprised 42% lipase concentration (per weight of oil), 32% water content (per weight of oil), a methanol to oil molar ratio of 3:1, pH 7.0 and reaction temperature 30oC, resulted in the highest fatty acid methyl ester (FAME) content (71.3%). Subsequently, the synergistic effect of two lipases with different regioselectivities, under the optimum transesterification conditions, was studied, aiming at the enhancement of process efficiency. The transesterification efficiency of immobilized Biolipasa-R was determined and compared to that of Biolipasa-R in its free form. The results revealed a good performance on FAME content (66.5%), while the recycling of immobilized lipase resulted in a decrease of transesterification efficiency after three consecutive uses.