bluuebunny/crossref_metadata_2025_split huggingface dataset:
The impact of an intervention to reduce dispersal from wastewater drain sites on carbapenem-resistant Pseudomonas aeruginosa colonization and bloodstream infection on a hematopoietic cell transplant and hematologic malignancy unit
Authors: Fontana Lauren , Hakki Morgan , Ozer Egon A. , Laird Amy , Strasfeld Lynne 
Published: February 2024

AbstractObjective:To evaluate the impact of an intervention to limit dispersal from wastewater drain (WWD) sites on meropenem-nonsusceptible Pseudomonas aeruginosa patient and environmental colonization and bloodstream infection (BSI) on a hematopoietic cell transplant (HCT) and hematologic malignancy (HM) unit.Design:This quasi-experimental study included pre/postintervention point-prevalence surveys in July 2019 and June 2020, respectively. The retrospective cohort included HCT/HM patients with P. aeruginosa BSI between 2012 and 2022.Setting:Adult HCT/HM unit at an academic center.Participants:This study included consenting HCT/HM patients on the unit at the time of the point-prevalence surveys. HCT/HM patients with P. aeruginosa BSI between 2012 and 2022.Methods:A quality improvement intervention targeting WWD sites was conceived and implemented on a HCT/HM unit. Pre and postintervention colonization samples were obtained from patients and environmental sites, cultivated on selective media, then characterized by susceptibility testing. Whole-genome sequencing and phylogenetic analysis were performed on select isolates. The impact of the intervention on colonization and BSI was evaluated, as was relatedness among isolates.Results:Although colonization of WWD sites with meropenem-nonsusceptible P. aeruginosa was widespread before and after this intervention, we observed a substantial decline in patient colonization (prevalence rate ratio, 0.35; 95% confidence interval [CI], 0.04–3.12) and BSI (incidence rate ratio, 0.67; 95% CI, 0.31–1.42) after the intervention. Among 3 predominant sequence types (ST-111, ST-446, and ST-308), there was striking genetic conservation within groups and among environmental colonization, patient colonization, and BSI isolates.Conclusions:An intervention targeting WWD sites on a HCT/HM unit had a meaningful impact on meropenem-nonsusceptible P. aeruginosa patient colonization and BSI.
Reviewing Planetary Health in light of Research Directions in One Health
Authors: Ternova Linda , Verger Lorenzo , Nagy Gustavo J. 
Published: February 2024

Abstract
Climate change significantly impacts our planet’s health, ecosystems, plants, animals and humans, increasing extreme weather events and the incidence and prevalence of infectious diseases, including zoonotic diseases. We reviewed the environmental changes affecting human, animal, and planetary health and conducted a bibliometric analysis from 2012-22 that included these components. We identified 448 publications published on the topic throughout that period. Then, we reflected on the Research Directions question: How can we improve and facilitate multi-sectoral collaboration in warning and response systems for infectious diseases and natural hazards to account for their drivers, interdependencies, and cascading impacts? The bibliometric analysis of planetary health has shown increasing interest among researchers since 2017, peaking in 2022. Lancet Planetary Health was the journal with more published articles; The London School of Hygiene and Tropical Medicine was the best-placed institution, and The United States led in topic-related publications. On the other hand, the climatic and pandemic global environmental crises demand fostered surveillance, which should concentrate on the drivers of disease, giving signals that account for human and animal health and environmental degradation. In response to global crises, higher education curricula should integrate One Health and Planetary Health approaches to achieve transdisciplinary thinking, allowing transcend knowledge, research and observation into action.
Utilisation of public healthcare services by an indigenous group: a mixed-method study among Santals of West Bengal, India
Authors: Mozumdar Arupendra , Das Bhubon Mohan , Kundu Chowdhury Tanaya , Roy Subrata K. 
Published: February 2024

AbstractA barrier to meeting the goal of universal health coverage in India is the inequality in utilisation of health services between indigenous and non-indigenous people. This study aimed to explore the determinants of utilisation, or non-utilisation, of public healthcare services among the Santals, an indigenous community living in West Bengal, India. The study holistically explored the utilisation of public healthcare facilities using a framework that conceptualised service coverage to be dependent on a set of determinants – viz. the nature and severity of the ailment, availability, accessibility (geographical and financial), and acceptability of the healthcare options and decision-making around these further depends on background characteristics of the individual or their family/household. This cross-sectional study adopts ethnographic approach for detailed insight into the issue and interviewed 422 adult members of Santals living in both rural (Bankura) and urban (Howrah) areas of West Bengal for demographic, socio-economic characteristics and healthcare utilisation behaviour using pre-tested data collection schedule. The findings revealed that utilisation of the public healthcare facilities was low, especially in urban areas. Residence in urban areas, being female, having higher education, engaging in salaried occupation and having availability of private allopathic and homoeopathic doctors in the locality had higher odds of not utilising public healthcare services. Issues like misbehaviour from the health personnel, unavailability of medicine, poor quality of care, and high patient load were reported as the major reasons for non-utilisation of public health services. The finding highlights the importance of improving the availability and quality of care of healthcare services for marginalised populations because these communities live in geographically isolated places and have low affordability of private healthcare. The health programme needs to address these issues to improve the utilisation and reduce the inequality in healthcare utilisation, which would be beneficial for all segments of Indian population.
Growth assessment of the sea urchin Pseudechinus magellanicus (Temnopleuridae) in coastal habitats of central Patagonia, Argentina
Authors: Gil Damián Gaspar , Zaixso Héctor Eliseo 
Published: February 2024

Abstract
Pseudechinus magellanicus is an ecologically important and small sea urchin in coastal and nearshore habitats off southern South America. We provide the first growth assessment for the species using tag (calcein) and recapture procedures in central Patagonia (Argentina). The individual growth rate of P. magellanicus ranged 0.05–1.3 mm year−1. The Brody–Bertalanffy and Richards growth models provided asymptotic maximum diameters of 29.89 and 26.01 mm, respectively. Both models yielded low values for the growth constant (k), with 0.046 (Brody–Bertalanffy) and 0.062 (Richards). Maximum instantaneous growth rate was estimated at 1.36 mm year−1 for the Brody–Bertalanffy model, and 2.69 mm year−1 for the Richards model. Model selection (corrected Akaike information criterion) showed a slight better fit for the Brody–Bertalanffy growth model compared to the Richards model. A significant variability in growth was observed within the studied population, which can be attributed to genetic factors and micro-environmental effects. P. magellanicus displays a combination of slow growth and small body size, with the lowest recorded growth performance index (θ = 3.72) recorded so far in sea urchins. The species has a long lifespan, with the most common adult sizes estimated to range from 15 to 21 years according to the Brody–Bertalanffy model. Due to the broad geographic distribution and occupation of contrasting habitats, further studies are necessary to explore growth of P. magellanicus under different environmental conditions and/or along a bathymetric gradient.
Magmatic Evolution of the Fossil Melanesian Island Arc: Evidence From Lower Miocene Lavas of Malekula Island (Vanuatu)
Authors: Haase K. M. , Schneider K. P. , Pelletier B. , Ishizuka O. 
Published: February 2024

AbstractThe subduction zones in the SW Pacific Ocean are some of the most dynamic plate boundaries on Earth with changes in subduction polarity and subduction initiation processes. The New Hebrides island arc formed some 10 million years ago after the Melanesian island arc was abandoned due to the cessation of subduction of the Pacific Plate after collision of oceanic plateaus with the island arc. Parts of the Melanesian island arc occur within the New Hebrides island arc and we show that Miocene volcanic rocks exposed on Malekula island in the New Hebrides island arc consist of island arc tholeiites to alkaline basalts with variable slab contribution. The lava erupted between 22.5 and 16.3 Ma, similar to the Wainimala Group lavas on Fiji representing the eastern portion of the Melanesian island arc. Partial melts from subducted sediments affected a Pacific MORB‐type mantle, but we do not find evidence for a slab component derived from the Ontong Java Plateau or for assimilation of continental crust. Thus, no Miocene subduction of the Ontong Java Plateau occurred beneath Malekula and the basement of the island probably does not consist of continental crust rifted from Australia. The Malekula lava succession resembles that of other portions of the Miocene Melanesian island arc between New Britain and Fiji, indicating continuous subduction of the Pacific plate along this arc.
Future Ozone Changes and Their Impacts on Vegetation and Human Health in China Under the Shared Socio‐Economic Pathways
Authors: Xu Chen , Mao Yu‐Hao , Liao Hong 
Published: February 2024

AbstractOzone concentrations in China are increasing in recent years and future changes of ozone and their impacts have attracted much attention. We use global chemical transport model (GEOS‐Chem) to simulate the surface ozone concentrations in China in 2020 and 2050 under four Shared Socio‐economic Pathways and evaluate the impacts of future ozone pollution on vegetation and premature mortality in four polluted regions (Beijing–Tianjin–Hebei, BTH; Yangtze River Delta, YRD; Pearl River Delta, PRD; Sichuan Basin, SCB) and three major crop growing areas (Huang–Huai–Hai, HHH; Northeast Plain, NEP; middle and lower reaches of Yangtze River, MLRY) in China. The changes of simulated seasonal maximum daily 8‐hr average (MDA8) ozone from 2020 to 2050 (−15.5 to +11.9 ppbv) are significant under SSP126 (low forcing pathway) and SSP245 (medium forcing pathway) scenarios in all regions due to large changes of emissions. MDA8 ozone in summer 2050 will be above the WHO guidelines (100 μg/m3) in BTH, YRD, HHH and MLRY under four scenarios. By 2050, W126 (vegetative ozone exposure index) in summer will be much above the maximum of US secondary standard (21 ppm‐h) in HHH under SSP245, SSP370 (medium to high forcing pathway) and SSP585 (high forcing pathway) scenarios, and in MLRY under SSP370 and SSP585 scenarios. Annual ozone‐related deaths for people over 30 years old will mainly decrease in four polluted areas from 2020 to 2050 under SSPs scenarios, but only increase much under SSP245 scenario in BTH (+3.1 to +4.2 thousand) and YRD (+1.1 to +1.6 thousand).
Measuring Erosional and Depositional Patterns Across Comet 67P's Imhotep Region
Authors: Jindal A. S. , Birch S. P. D. , Hayes A. G. , Özyurt F. P. , Issah A. B. , Moruzzi S. A. , Barrington M. N. , Soderblom J. M. , Kirk R. L. , Marschall R. , Vincent J. B. 
Published: February 2024

AbstractComet 67P/Churyumov‐Gerasimenko displays a pronounced hemispherical dichotomy in surface morphology, where the southern hemisphere exhibits more erosional features than the northern hemisphere due to receiving much greater solar radiation. Consequently, it is generally assumed that particles are ejected from the southern hemisphere through sublimation and a significant fraction eventually descends as airfall, covering the northern terrains. To investigate this south‐to‐north material transfer during the comet's perihelion passage, we used photoclinometry to measure material redistribution within its most extensive smooth terrain deposit around the Imhotep region. However, our findings do not align with this expected trend. Instead, we show that local‐scale processes substantially impact the erosion and accumulation of material, with one area experiencing net erosion while another nearby region, just a few dozen meters away, sees sediment buildup. Our analysis underscores the complex interplay of processes shaping Comet 67P's surface and likely comets more generally.
Simulated Future Shifts in Wildfire Regimes in Moist Forests of Pacific Northwest, USA
Authors: Dye Alex W. , Reilly Matt J. , McEvoy Andy , Lemons Rebecca , Riley Karin L. , Kim John B. , Kerns Becky K. 
Published: February 2024

AbstractFire is an integral natural disturbance in the moist temperate forests of the Pacific Northwest of the United States, but future changes remain uncertain. Fire regimes in this climatically and biophysically diverse region are complex, but typically climate limited. One challenge for interpreting potential changes is conveying projection uncertainty. Using projections of Energy Release Component (ERC) derived from 12 global climate models (GCM) that vary in performance relative to the region's contemporary climate, we simulated thousands of plausible fire seasons with the stochastic spatial fire spread model FSim for mid‐21st century (2035–2064) under RCP8.5 emissions scenario for five northwestern pyromes. The magnitude of projected changes to burn probability, fire size, and number of fires varied among pyromes and GCMs. We projected the largest increases in burn probability and fire size in the cooler and wetter northern parts of the region (North Cascades, Olympics & Puget Lowlands) and Oregon West Cascades, with more moderate changes projected for the Washington West Cascades and Oregon Coast Range. We provide new insights into changing fire regimes characterized by the possibility of shifts toward more frequent and large fires (especially >40,000 ha), as well as shifts in seasonality, including more fires burning at the beginning of fall when extreme synoptic weather events have the potential to increase fire spread. Our work highlights the potential geographic variability in climate change effects in some of the most productive moist temperate forests of the world and points to a rapid acceleration of fire in the coming decades.
Peatlands Versus Permafrost: Landscape Features as Drivers of Dissolved Organic Matter Composition in West Siberian Rivers
Authors: Starr Sommer F. , Frey Karen E. , Smith Laurence C. , Kellerman Anne M. , McKenna Amy M. , Spencer Robert G. M. 
Published: February 2024

AbstractWest Siberia contains some of the largest soil carbon stores on Earth owing to vast areas of peatlands and permafrost, with the region warming far faster than the global average. Organic matter transported in fluvial systems is likely to undergo distinct compositional changes as peatlands and permafrost warm. However, the influence of peatlands and permafrost on future dissolved organic matter (DOM) composition is not well characterized. To better understand how these environmental drivers may impact DOM composition in warming Arctic rivers, we used ultrahigh resolution Fourier‐transform ion cyclotron resonance mass spectrometry to analyze riverine DOM composition across a latitudinal gradient of West Siberia spanning both permafrost‐influenced and permafrost‐free watersheds and varying proportions of peatland cover. We find that peatland cover explains much of the variance in DOM composition in permafrost‐free watersheds in West Siberia, but this effect is suppressed in permafrost‐influenced watersheds. DOM from warm permafrost‐free watersheds was more heterogenous, higher molecular weight, and relatively nitrogen enriched in comparison to DOM from cold permafrost‐influenced watersheds, which were relatively enriched in energy‐rich peptide‐like and aliphatic compounds. Therefore, we predict that as these watersheds warm, West Siberian rivers will export more heterogeneous DOM with higher average molecular weight than at present. Such compositional shifts have been linked to different fates of DOM in downstream ecosystems. For example, a shift toward higher molecular weight, less energy‐rich DOM may lead to a change in the fate of this material, making it more susceptible to photochemical degradation processes, particularly in the receiving Arctic Ocean.
Cancer-associated fibroblasts rewire the estrogen receptor response in luminal breast cancer, enabling estrogen independence
Authors: Reid Steven E. , Pantaleo Jessica , Bolivar Paulina , Bocci Matteo , Sjölund Jonas , Morsing Mikkel , Cordero Eugenia , Larsson Sara , Malmberg Maria , Seashore-Ludlow Brinton , Pietras Kristian 
Published: February 2024

AbstractAdvanced breast cancers represent a major therapeutic challenge due to their refractoriness to treatment. Cancer-associated fibroblasts (CAFs) are the most abundant constituents of the tumor microenvironment and have been linked to most hallmarks of cancer. However, the influence of CAFs on therapeutic outcome remains largely unchartered. Here, we reveal that spatial coincidence of abundant CAF infiltration with malignant cells was associated with reduced estrogen receptor (ER)-α expression and activity in luminal breast tumors. Notably, CAFs mediated estrogen-independent tumor growth by selectively regulating ER-α signaling. Whereas most prototypical estrogen-responsive genes were suppressed, CAFs maintained gene expression related to therapeutic resistance, basal-like differentiation, and invasion. A functional drug screen in co-cultures identified effector pathways involved in the CAF-induced regulation of ER-α signaling. Among these, the Transforming Growth Factor-β and the Janus kinase signaling cascades were validated as actionable targets to counteract the CAF-induced modulation of ER-α activity. Finally, genes that were downregulated in cancer cells by CAFs were predictive of poor response to endocrine treatment. In conclusion, our work reveals that CAFs directly control the luminal breast cancer phenotype by selectively modulating ER-α expression and transcriptional function, and further proposes novel targets to disrupt the crosstalk between CAFs and tumor cells to reinstate treatment response to endocrine therapy in patients.
Neural sensitivity following stress predicts anhedonia symptoms: a 2-year multi-wave, longitudinal study
Authors: Kirshenbaum Jaclyn S. , Pagliaccio David , Pizzagalli Diego A. , Auerbach Randy P. 
Published: February 2024

AbstractAnimal models of depression show that acute stress negatively impacts functioning in neural regions sensitive to reward and punishment, often manifesting as anhedonic behaviors. However, few human studies have probed stress-induced neural activation changes in relation to anhedonia, which is critical for clarifying risk for affective disorders. Participants (N = 85, 12–14 years-old, 53 female), oversampled for risk of depression, were administered clinical assessments and completed an fMRI guessing task during a baseline (no-stress) period to probe neural response to receipt of rewards and losses. After the initial task run of the fMRI guessing task, participants received an acute stressor and then, were re-administered the guessing task. Including baseline, participants provided up to 10 self-report assessments of life stress and symptoms over a 2 year period. Linear mixed-effects models estimated whether change in neural activation (post- vs. pre-acute stressor) moderated the longitudinal associations between life stress and symptoms. Primary analyses indicated that adolescents with stress-related reductions in right ventral striatum response to rewards exhibited stronger longitudinal associations between life stress and anhedonia severity (β = −0.06, 95%CI[−0.11, −0.02], p = 0.008, pFDR = 0.048). Secondary analyses showed that longitudinal positive associations between life stress and depression severity were moderated by stress-related increases in dorsal striatum response to rewards (left caudate β = 0.11, 95%CI[0.07,0.17], p < 0.001, pFDR = 0.002; right caudate β = 0.07, 95%CI[0.02,0.12], p = 0.002, pFDR = 0.003; left putamen β = 0.09, 95%CI[0.04, 0.14], p < 0.001, pFDR = 0.002; right putamen β = 0.08, 95%CI[0.03, 0.12], p < 0.001, pFDR = 0.002). Additionally, longitudinal positive associations among life stress and anxiety severity were moderated by stress-related reductions in dorsal anterior cingulate cortex (β = −0.07, 95%CI[−0.12,.02], p = 0.008, pFDR = 0.012) and right anterior insula (β = −0.07, 95%CI[−0.12,−0.02], p = 0.002, pFDR = 0.006) response to loss. All results held when adjusting for comorbid symptoms. Results show convergence with animal models, highlighting mechanisms that may facilitate stress-induced anhedonia as well as a separable pathway for the emergence of depressive and anxiety symptoms.
CHOP-mediated Gasdermin E expression promotes pyroptosis, inflammation, and mitochondrial damage in renal ischemia-reperfusion injury
Authors: Ma Nannan , Lu Hao , Li Ning , Ni Weijian , Zhang Wenbo , Liu Qiang , Wu Wenzheng , Xia Shichao , Wen Jiagen , Zhang Tao 
Published: February 2024

AbstractIn clinical practice, renal ischemia-reperfusion injury (IRI) is a common cause of acute kidney injury (AKI), often leading to acute renal failure or end-stage renal disease (ESRD). The current understanding of renal IRI mechanisms remains unclear, and effective therapeutic strategies and clear targets are lacking. Therefore, the need to find explicit and effective ways to reduce renal IRI remains a scientific challenge. The current study explored pyroptosis, a type of inflammation-regulated programmed cell death, and the role of Gasdermins E (GSDME)-mediated pyroptosis, mitochondrial damage, and inflammation in renal IRI. The analysis of human samples showed that the expression levels of GSDME in normal human renal tissues were higher than those of GSDMD. Moreover, our study demonstrated that GSDME played an important role in mediating pyroptosis, inflammation, and mitochondrial damage in renal IRI. Subsequently, GSDME-N accumulated in the mitochondrial membrane, leading to mitochondrial damage and activation of caspase3, which generated a feed-forward loop of self-amplification injury. However, GSDME knockout resulted in the amelioration of renal IRI. Moreover, the current study found that the transcription factor CHOP was activated much earlier in renal IRI. Inhibition of BCL-2 by CHOP leaded to casapse3 activation, resulting in mitochondrial damage and apoptosis; not only that, but CHOP positively regulated GSDME thereby causing pyroptosis. Therefore, this study explored the transcriptional mechanisms of GSDME during IRI development and the important role of CHOP/Caspase3/GSDME mechanistic axis in regulating pyroptosis in renal IRI. This axis might serve as a potential therapeutic target.