bluuebunny/crossref_metadata_2025_split huggingface dataset:
Russia in a changing climate
Authors: Javeline Debra , Orttung Robert , Robertson Graeme , Arnold Richard , Barnes Andrew , Henry Laura , Holland Edward , Omelicheva Mariya , Rutland Peter , Schatz Edward , Schenk Caress , Semenov Andrei , Sperling Valerie , McIntosh Sundstrom Lisa , Troitskiy Mikhail , Twigg Judyth , Wengle Susanne 
Published: December 2023

AbstractClimate change will shape the future of Russia, and vice versa, regardless of who rules in the Kremlin. The world's largest country is warming faster than Earth as a whole, occupies more than half the Arctic Ocean coastline, and is waging a carbon‐intensive war while increasingly isolated from the international community and its efforts to reduce greenhouse gas emissions. Officially, the Russian government argues that, as a major exporter of hydrocarbons, Russia benefits from maintaining global reliance on fossil fuels and from climate change itself, because warming may increase the extent and quality of its arable land, open a new year‐round Arctic sea route, and make its harsh climate more livable. Drawing on the collective expertise of a large group of Russia‐focused social scientists and a comprehensive literature review, we challenge this narrative. We find that Russia suffers from a variety of impacts due to climate change and is poorly prepared to adapt to these impacts. The literature review reveals that the fates of Russia's hydrocarbon‐dependent economy, centralized political system, and climate‐impacted population are intertwined and that research is needed on this evolving interrelationship, as global temperatures rise and the international economy decarbonizes in response.This article is categorized under:
Policy and Governance > National Climate Change Policy
Trans‐disciplinary Perspectives > National Reviews
Trans‐disciplinary Perspectives > Regional Reviews
Predictive risk model of recurrence of acute diverticulitis after the first episode
Authors: Pastor‐Mora Juan Carlos , Fortea‐Sanchís Carlos , Coret‐Franco Alba , García‐Martínez Juan Antonio , Cosa‐Rodriguez Rebeca , Nomdédeu‐Guinot Jesus , Gibert‐Gerez Juan , Laguna‐Sastre Manuel , Llueca Antoni 
Published: December 2023

AbstractIntroductionThe recurrence of acute diverticulitis (AD) of the colon is frequent and leads to hospital readmissions and the need for elective surgery in selected cases. It is important to individualize risk factors and develop predictive tools for their identification.Materials and methodsThis prospective observational study included 368 patients who were diagnosed with AD between 2016 and 2021 in a tertiary general university hospital during their first episode and who had a good response to antibiotic, percutaneous, or peritoneal lavage treatment. Univariate and multivariate Cox regression analyses of the variables associated with recurrence were performed. Subsequently, a predictive risk score was developed and validated through survival studies.ResultsAfter a median follow‐up of 50 months, there were 71 (19.3%) cases of recurrence out of a total of 368 patients. The mean time of recurrence was 15 months, and 73.3% of cases of recurrence occurred before 2 years of follow‐up. Recurrence was independently associated with presentation with colonic perforation in the antimesenteric location (HR 3.67 95% CI [1.59–8.4]) and a CRP level greater than 100 mg/dl (HR 1.69 95% CI [1.04–2.77). A score with 5 variables was created that differentiated two risk groups: intermediate risk (0–3 points), with 19% recurrence and high risk (more than 3 points), with 42% recurrence.ConclusionsThe risk of recurrence after the first episode of diverticulitis can be estimated using predictive scores. The detection of high‐risk patients facilitates the individualization of follow‐up and treatment.
Marine Protected Area Expansion and Country-Level Age-Standardized Adult Mortality
Authors: Haque Sabrina S. , Bennett Baylin J. , Brewer Thomas D. , Morrissey Karyn , Fleming Lora E. , Gribble Matthew O. 
Published: December 2023

AbstractMany countries have adopted targets to increase marine protected areas (MPAs) to limit the degradation of water bodies. Although there is evidence that MPAs can conserve marine life and promote biodiversity, there are limited data on the human health implications of MPAs. Using panel data from 1990, 2000, and 2014, we estimated the country-level associations between MPAs (i.e., percentage of territorial waters designated as marine reserves) and age-standardized mortality (i.e., age-standardized probability of dying between 15 and 60 years from all-causes among ages 15–60/100,000 population) by sex, among 110 countries. We fit mixed-effects linear regression models of mortality as a function of current MPA coverage, gross domestic product growth, year, the prior extent of MPA, electricity coverage, governance, and country-level random effects. We observed a significant inverse association between current MPA coverage and adult mortality. For each 5-percentage-point increase in current MPA coverage, a country had 0.982 times the geometric means of female and male mortality [geometric mean ratio: 0.982 (95% CI 0·976, 0·988)] conditional on past %MPA coverage and other modeled variables. The model showed no significant residual association of mortality with past %MPA conditional on current %MPA and other modeled variables. This is one of the first studies to show a positive association between increasing marine conservation and human health. This macro-level study suggests there may be important co-benefits for human health from expanding MPAs that merit further investigation.
Disentanglement of Resting State Brain Networks for Localizing Epileptogenic Zone in Focal Epilepsy
Authors: Ye Shuai , Bagić Anto , He Bin 
Published: December 2023

AbstractThe objective of this study is to extract pathological brain networks from interictal period of E/MEG recordings to localize epileptic foci for presurgical evaluation. We proposed here a resting state E/MEG analysis framework, to disentangle brain functional networks represented by neural oscillations. By using an Embedded Hidden Markov Model, we constructed a state space for resting state recordings consisting of brain states with different spatiotemporal patterns. Functional connectivity analysis along with graph theory was applied on the extracted brain states to quantify the network features of the extracted brain states, based on which the source location of pathological states is determined. The method is evaluated by computer simulations and our simulation results revealed the proposed framework can extract brain states with high accuracy regarding both spatial and temporal profiles. We further evaluated the framework as compared with intracranial EEG defined seizure onset zone in 10 patients with drug-resistant focal epilepsy who underwent MEG recordings and were seizure free after surgical resection. The real patient data analysis showed very good localization results using the extracted pathological brain states in 6/10 patients, with localization error of about 15 mm as compared to the seizure onset zone. We show that the pathological brain networks can be disentangled from the resting-state electromagnetic recording and could be identified based on the connectivity features. The framework can serve as a useful tool in extracting brain functional networks from noninvasive resting state electromagnetic recordings, and promises to offer an alternative to aid presurgical evaluation guiding intracranial EEG electrodes implantation.
Influence of a Short Course of Ritonavir Used as Booster in Antiviral Therapies Against SARS-CoV-2 on the Exposure of Atorvastatin and Rosuvastatin
Authors: Krohmer Evelyn , Rohr Brit Silja , Stoll Felicitas , Gümüs Katja S. , Bergamino Mariano , Mikus Gerd , Sauter Max , Burhenne Jürgen , Weiss Johanna , Meid Andreas D. , Czock David , Blank Antje , Haefeli Walter E. 
Published: December 2023

Abstract
Purpose
Early antiviral treatment with nirmatrelvir/ritonavir is recommended for SARS-CoV-2-infected patients at high risk for severe courses. Such patients are usually chronically ill and susceptible to adverse drug interactions caused by ritonavir. We investigated the interactions of short-term low-dose ritonavir therapy with atorvastatin and rosuvastatin, two statins commonly used in this population.

Method
We assessed exposure changes (area under the concentration–time curve (AUC∞) and maximum concentration (Cmax)) of a single dose of 10 mg atorvastatin and 10 mg rosuvastatin before and on the fifth day of ritonavir treatment (2 × 100 mg/day) in healthy volunteers and developed a semi-mechanistic pharmacokinetic model to estimate dose adjustment of atorvastatin during ritonavir treatment.

Results
By the fifth day of ritonavir treatment, the AUC∞ of atorvastatin increased 4.76-fold and Cmax 3.78-fold, and concurrently, the concentration of atorvastatin metabolites decreased to values below the lower limit of quantification. Pharmacokinetic modelling indicated that a stepwise reduction in atorvastatin dose during ritonavir treatment with a stepwise increase up to 4 days after ritonavir discontinuation can keep atorvastatin exposure within safe and effective margins. Rosuvastatin pharmacokinetics were only mildly modified; ritonavir significantly increased the Cmax 1.94-fold, while AUC∞ was unchanged.

Conclusion
Atorvastatin doses should likely be adjusted during nirmatrelvir/ritonavir treatment. For patients on a 20-mg dose, we recommend half of the original dose. In patients taking 40 mg or more, a quarter of the dose should be taken until 2 days after discontinuation of nirmatrelvir/ritonavir. Patients receiving rosuvastatin do not need to change their treatment regimen.

Trial Registration
EudraCT number: 2021–006634-39.
DRKS00027838.
The capture probability of Dawn into ground-track resonances with Vesta
Authors: Boumchita Wail , Feng Jinglang 
Published: December 2023

AbstractThe Dawn spacecraft approached the asteroid Vesta and descended from a high-altitude mission orbit to a low-altitude mission orbit using low-thrust propulsion. During this descent, the spacecraft crossed the 2:3 and 1:1 ground-track resonances with Vesta, which posed a risk of capture that might strongly perturb the spacecraft’s orbit. This study analyzes the effects of these resonances on the spacecraft’s orbital elements and estimates the probability of capture into it through Monte Carlo simulations. Specifically, a comprehensive investigation is performed to assess the effects of 1:1 and 2:3 ground-track resonances on the semimajor axis, eccentricity, and inclination. The dynamical model includes the gravitational field of Vesta using a spherical harmonics approximation up to the fourth degree and order and the low-thrust acceleration that is assumed to be opposite to the spacecraft’s velocity vector direction. It is observed that the eccentricity evolution is mostly influenced by the 2:3 ground-track resonance which results in a large variation when the spacecraft crosses that ground-track resonance, while the semimajor axis and inclination are mostly influenced by the 1:1 ground-track resonance. Then, the probability of capture into 1:1 ground-track resonance is found to have a negative correlation with the spacecraft’s thrust magnitude and the probability of capture into 2:3 ground-track resonance is found to arise as the spacecraft’s mass increases. It is found that for circular orbits below a certain inclination value the spacecraft’s trajectory is subject to the “automatic entry into libration” phenomenon, due to the singularity in the Hamiltonian function. This research contributes to the design of successful transfer strategies when crossing resonance for future missions.
Psychotropic Medication Use in Children and Youth with Autism Enrolled in Medicaid
Authors: Rast Jessica E. , Tao Sha , Schott Whitney , Shea Lindsay L. , Brodkin Edward S. , Kerns Connor M. , Leonard Charles E. , Murray Michael J. , Lee Brian K. 
Published: December 2023

Abstract
Children with autism frequently present with complex mental health diagnoses and psychotropic medications are often a component of comprehensive biopsychosocial treatment plans for these conditions. The purpose of this study is to provide rates and patterns of psychotropic medication use, and predictors thereof, in children and youth with autism enrolled in Medicaid across the US. This study examined national Medicaid claims from 2008 to 2016 of all children and youth with autism ages 0–21 years enrolled in Medicaid. Psychotropic medication use was examined across several child and youth characteristics, including age, co-occurring mental health conditions, sex, and race and ethnicity. About half of children and youth with autism enrolled in Medicaid had at least one psychotropic prescription in a year, a number that decreased slightly across the study period due to decreases in the prescription of antipsychotics. As new medications for autism or co-occurring conditions are developed and deployed, and as the understanding of the characteristics of the population of children with autism evolves, studying rates of medication usage helps to understand utilization patterns and differences in access to quality care.
The Impact of Surface Passivation on Kapitza Resistance at the Interface Between a Semiconductor and Liquid Nitrogen
Authors: Mohammadian Babak , McCulloch Mark A. , Sweetnam Thomas , Gilles Valerio , Piccirillo Lucio 
Published: December 2023

AbstractCooling electronic devices to cryogenic temperatures (< 77 K) is crucial in various scientific and engineering domains. Efficient cooling involves the removal of heat generated from these devices through thermal contact with either a liquid cryogen or a dry cryostat cold stage. However, as these devices cool, thermal boundary resistance, also known as Kapitza resistance, hinders the heat flow across thermal interfaces, resulting in elevated device temperatures. In transistors, the presence of passivation layers like silicon nitride (SiN) introduces additional interfaces that further impede heat dissipation. This paper investigates the impact of passivation layer thickness on Kapitza resistance at the interface between a solid device and liquid nitrogen. The Kapitza resistance is measured using a capacitance thermometer that has been passivated with SiN layers ranging from 0 to 240 nm. We observe that Kapitza resistance increases with increasing passivation thickness.
The Time-Dependent Symbol of a Non-homogeneous Itô Process and Corresponding Maximal Inequalities
Authors: Rickelhoff Sebastian , Schnurr Alexander 
Published: December 2023

AbstractThe probabilistic symbol is defined as the right-hand side derivative at time zero of the characteristic functions corresponding to the one-dimensional marginals of a time-homogeneous stochastic process. As described in various contributions to this topic, the symbol contains crucial information concerning the process. When leaving time-homogeneity behind, a modification of the symbol by inserting a time component is needed. In the present article, we show the existence of such a time-dependent symbol for non-homogeneous Itô processes. Moreover, for this class of processes, we derive maximal inequalities which we apply to generalize the Blumenthal–Getoor indices to the non-homogeneous case. These are utilized to derive several properties regarding the paths of the process, including the asymptotic behavior of the sample paths, the existence of exponential moments and the finiteness of p-variationa. In contrast to many situations where non-homogeneous Markov processes are involved, the space-time process cannot be utilized when considering maximal inequalities.
Ensuring the accuracy of indirect nonlinear dynamic reduced-order models
Authors: Xiao Xiao , Hill Thomas L. , Neild Simon A. 
Published: December 2023

AbstractNumerous powerful methods exist for developing reduced-order models (ROMs) from finite element (FE) models. Ensuring the accuracy of these ROMs is essential; however, the validation using dynamic responses is expensive. In this work, we propose a method to ensure the accuracy of ROMs without extra dynamic FE simulations. It has been shown that the well-established implicit condensation and expansion (ICE) method can produce an accurate ROM when the FE model’s static behaviour are captured accurately. However, this is achieved via a fitting procedure, which may be sensitive to the selection of load cases and ROM’s order, especially in the multi-mode case. To alleviate this difficulty, we define an error metric that can evaluate the ROM’s fitting error efficiently within the displacement range, specified by a given energy level. Based on the fitting result, the proposed method provides a strategy to enrich the static dataset, i.e. additional load cases are found until the ROM’s accuracy reaches the required level. Extending this to the higher-order and multi-mode cases, some extra constraints are incorporated into the standard fitting procedure to make the proposed method more robust. A curved beam is utilised to validate the proposed method, and the results show that the method can robustly ensure the accuracy of the static fitting of ROMs.
What do emergency department pharmacist practitioners know and understand about patient safeguarding? A qualitative study
Authors: Greenwood Daniel , Steinke Douglas , Martin Sandra , Norton Gary , Tully Mary P. 
Published: December 2023

Abstract
Background
Pharmacists with additional clinical skills now work in UK emergency departments. Known as Emergency Department Pharmacist Practitioners, the role was developed in response to a shortage of physicians and nurses. They carry out activities typical of traditional hospital pharmacists, but also novel ‘practitioner’ activities such as examining patients, and acting as designated care provider. The role includes a responsibility to safeguard patients from harm. Professional competence, i.e. to safeguard patients, is underpinned by knowledge of the subject, but also knowledge application.

Aim
To investigate what Emergency Department Pharmacist Practitioners know and understand about safeguarding vulnerable children and adults.

Method
Thirteen Emergency Department Pharmacist Practitioners were interviewed to explore their knowledge and understanding of safeguarding. Interview questions were developed from review of relevant literature, as were vignettes with variables identified and altered to produce different scenarios. Template analysis was used to code data to a priori themes for each of the stages of the initial safeguarding process, and new themes that emerged throughout the process.

Results
Six themes were identified in addition to the four a priori themes. Overall, participants frequently described how safeguarding concerns are both recognised and responded to, but seemed more comfortable when responding to medicines related concerns. Factors thought to influence the safeguarding process included: resources and setting; and education, training and experiential learning; and culture.

Conclusion
While Emergency Department Pharmacist Practitioners interviewed were aware of the safeguarding process, there were some misconceptions as to the roles of different healthcare workers in this process.
The effectiveness of ibandronate in reducing the risk of nonvertebral fractures in women with osteoporosis: systematic review and meta-analysis of observational studies
Authors: Alves Carlos , Mendes Diogo , Penedones Ana , Oliveira Tânia , Donato António , Batel-Marques Francisco 
Published: December 2023

Abstract
Background
Ibandronate is effective in reducing the risk of vertebral fractures, but experimental evidence offers conflicting results regarding nonvertebral fractures. Real-world evidence has been published evaluating the anti-nonvertebral fracture effect of ibandronate.

Aim
This meta-analysis of observational studies assessed the effectiveness of ibandronate in reducing the risk of nonvertebral fractures in women with osteoporosis.

Method
Pubmed/Embase databases were searched for observational studies. Risks of nonvertebral fractures and hip fractures were the outcomes. Meta-analyses were performed pooling rate ratios (RRs), using random-effects models. Data were reanalysed in sensitivity analyses considering Knapp–Hartung method and Bayesian random-effects.

Results
Six cohort studies were included. Overall, once-monthly 150 mg oral ibandronate reduced the risk of nonvertebral fractures (RR 0.84; 95% CI 0.76–0.94). Similar results were obtained when the comparison was restricted to once-monthly 150 mg risedronate, but no differences were found when the comparator was other oral bisphosphonates (weekly alendronate/risedronate). Ibandronate didn’t significantly change the risk of hip fractures (RR 1.25; 95% CI 0.89–1.76). The risk of hip fracture was comparable between once monthly, 150 mg oral ibandronate and other oral bisphosphonates. Intravenous ibandronate was not effective in reducing hip fractures comparing to intravenous zoledronate. The low number of studies diminished the robustness of sensitivity analyses.

Conclusion
Results suggest that once-monthly 150 mg oral ibandronate may be as effective as other oral bisphosphonates in reducing the risk of nonvertebral fractures. However, uncertainty associated to the small number of included studies, which are characterized by heterogeneous demographics and methodologies, precluded definitive conclusions.
Validation of the brain injury associated visual impairment - impact questionnaire (BIVI-IQ)
Authors: Hepworth L. R. , Kirkham J.J. , Perkins E. , Helliwell B. , Howard C. , Liptrot M. , Tawana S. , Wilson E. , Rowe F. J. 
Published: December 2023

Abstract
Purpose
The Brain Injury associated Visual Impairment - Impact Questionnaire (BIVI-IQ) was developed to assess the impact of post-stroke visual impairment. The development of the questionnaire used robust methods involving stroke survivors and clinicians. The aim of this study was to assess the validity of the BIVI-IQ in a stroke population.

Methods
Stroke survivors with visual impairment were recruited from stroke units, outpatient clinics and non-healthcare settings. Participants were asked to complete questionnaire sets on three separate occasions; the BIVI-IQ at each visit with additional questionnaires at baseline and visit 2. Vision assessment and anchor questions from participants and clinicians were collected. The analysis included assessment of missing data, acceptability, Rasch model analysis, test–retest reliability, construct validity (NEI VFQ-25, EQ-5D-5L) and responsiveness to change.

Results
316 stroke survivors completed at least one questionnaire of the 326 recruited. Mean age was 67 years and 64% were male. Adequate fit statistics to the Rasch model were reached (χ2 = 73.12, p = 0.02) with two items removed and thresholds of two adjusted, indicating validity and unidimensionality. Excellent test–retest reliability was demonstrated (ICC = 0.905) with a 3-month interval. Construct validity was demonstrated with a strong significant correlation to the NEI VFQ-25 (r = 0.837, p < 0.01). The BIVI-IQ also demonstrated responsiveness to change with significant differences identified between groups based on participant and clinician anchor questions (X2 = 23.29, p < 0.001; X2 = 24.56, p < 0.001).

Conclusion
The BIVI-IQ has been shown to be valid and practical for ‘everyday’ use by clinicians and researchers to monitor vision-related quality of life in stroke survivors with visual impairment.