bluuebunny/crossref_metadata_2025_split huggingface dataset:
Data-Driven Approach to Predict the Fundamental Period of Steel-Braced RC Frames Using Stacked Generalization Machine Learning Models
Authors: Rahman Taimur , Hasan Md Hasibul , Momin Md. Farhad , Zheng Pengfei 
Published: October 2023

Abstract

The study is directed toward the precise prediction of the fundamental period of steel-braced Reinforced Concrete (RC) Moment-Resisting Frames (MRFs) through the utilization of stacked generalization, an advanced algorithmic ensemble machine learning technique. To facilitate this, a meticulously curated database comprising 17,280 building models has been automated using the ETABS Application Programming Interface (API). The database encompasses both Concentrically Braced Frames (CBFs) and Eccentrically Braced Frames (EBFs) and employs eigenvalue modal analysis to capture the fundamental periods, incorporating diverse bracing configurations and pivotal building parameters. Utilizing SHapley Additive exPlanations (SHAP), the study rigorously scrutinizes influential parameters that affect the fundamental period. The research introduces three stacking ensemble models, with the most effective model employing Random Forest as the meta-model and an ensemble of Extra Trees, Gradient Boosting, XGBoost, LightGBM, CatBoost, and kNN as base models. Hyperparameter tuning was accomplished through Bayesian Optimization, and a thorough sensitivity analysis was conducted. In rigorous evaluations conducted on the test dataset, the proposed model achieved an exceptionally high coefficient of determination (R2) of 0.9889, coupled with an impressively low root mean square error (RMSE) of 0.056. Further validation through multi-dimensional metrics confirmed the model's robust generalization capabilities. Comparative validation against a few popular building code provisions and research models revealed that the proposed model markedly surpasses these benchmarks in predictive accuracy.
Stigma, risks, and benefits of medicinal cannabis use among Australians with cancer
Authors: Morris Julia N , Loyer Jessica , Blunt Jason 
Published: October 2023

Abstract
Purpose
People with cancer who use medicinal cannabis do so despite risks associated with limited clinical evidence, legalities, and stigma. This study investigated how Australians with cancer rationalise their medicinal cannabis use despite its risks.
Methods
Ten adults who used cannabis medicinally for their cancer were interviewed about how they used and accessed the substance, attitudes and beliefs underpinning their use, and conversations with others about medicinal cannabis.
Results
Participants used cannabis to treat a variety of cancer-related symptoms such as pain, poor sleep, and low mood. Cannabis was perceived as natural and thus less risky than pharmaceuticals. Participants legitimised their medicinal cannabis use by emphasising its natural qualities and distancing themselves from problematic users or riskier substances. Cost barriers and a lack of healthcare professional communication impeded prescription access. Similarly, participants navigated medicinal cannabis use independently due to a lack of guidance from healthcare professionals.
Conclusion
Findings highlight the need for robust data regarding the harms and efficacy of medicinal cannabis that healthcare professionals can disseminate to patients who choose to use the substance. Ensuring healthcare professionals are equipped to provide non-judgmental and evidence-based guidance may mitigate potential safety and legal risks.
Analysis of influence factors of target polarization characteristics
Authors: Zhang Zhiwei , Yang Zhiyong , Li Gengpeng , Chen Dong , Wang Xiaowei 
Published: October 2023

Abstract
The target polarization characteristics reflect the important information about the medium material, surface texture, and structural characteristics of the target itself. In this paper, 9 kinds of samples with different materials, roughness, and surface texture direction are selected to measure the polarization characteristics in an outdoor environment, and the influencing factors of the target polarization characteristics are analyzed, where the influence of the surface texture direction on the spatial distribution of the target polarization characteristics is emphatically analyzed. The results show that the target polarization characteristics are affected by many factors such as material, roughness, surface texture direction, and detection position, and the greater the angle between the surface texture direction and the principal plane, the more concentrated the target polarization characteristics are in and around the principal plane, which could provide a theoretical basis for comprehensively mastering the target polarization characteristics, improving the ability of target polarization detection and recognition, and enhancing the confidence of the target polarization modeling and simulation.
Young older adults at risk of not having a good later life and the implications for mental health and wellbeing: evidence from the English Longitudinal Study of Ageing
Authors: Zaninotto Paola , Steptoe Andrew 
Published: October 2023

Abstract

We identified risk categories of not having a good later life among young older people and reported the consequences that being in these groups have on mental health and wellbeing.
3,511 participants aged 50 to 69 from the English Longitudinal Study of Ageing (ELSA) provided data on 10 domains of a good later life. The domains were then entered into a model to identify risk groups using Latent Class Analysis. Regression models were used to assess the association between identified risk groups and depression, life satisfaction, loneliness and wellbeing. We found that 20% of individuals were in the “high” risk group for not having a good later life. These people were more likely to report depression, loneliness, lower life satisfaction and lower wellbeing than those in the low risk group. Being at risk of not having a good later life has important consequences for mental health and wellbeing. Appropriate support and services should be in place to ensure that everyone is able to live longer in good mental health.
A high‑efficiency Agrobacterium tumefaciens‑mediated transient expression system in the leaves of Spinacia oleracea
Authors: Zhang Yumeng , Qiu Liuliu , Zhang Yongxue , Wang Yiran , Wang Quanhua , Fu Chunxiang , Dai Shaojun , Sun Meihong 
Published: October 2023

Abstract

Background The establishment of a highly efficient transient expression system is critical for the study of gene function, particularly in plants for which stable transformation methods are not widely available. Agrobacterium tumefaciens‑mediated transient transformation is a simple and low-cost method that has been extensively developed and applied to a wide variety of plant species. However, the transient expression in spinach (Spinacia oleracea L.) is still not reported.
Results Here, we performed a transient expression system in leaves of spinach variety Sp75 and Sp73. Several factors influencing the transformation efficiency were optimized such as Agrobacterium strain, spinach seedling stage, leaf position, and the expression time after injection. Agrobacterium strain GV3101 (pSoup-p19) was more effective than AGL1 in expressing recombinant protein in spinach leaves. In general, the leaves of Sp75 were more suitable than those of Sp73 no matter at four-leaf stage or at six-leaf stage. At four-leaf stage, higher transient expression intensity and efficiency were observed in group 1 (G1) of Sp75 at 53 hours after injection (HAI) and in G1of Sp73 at 64 HAI. At six-leaf stage of Sp75, group 3 (G3) at 72 HAI were the most effective condition for transient expression. Using the optimized expression system, we detected the subcellular localization of a transcriptional co-activator SoMBF1c and a NADPH oxidase SoRbohF. We also detected the interaction of the protein kinase SoCRK10 and the NADPH oxidase SoRbohB.
Conclusion This study established a high‑efficiency Agrobacterium‑mediated transient expression method using spinach leaves. The transient expression system will facilitate the gene function analysis and lay a solid foundation for molecular design breeding of spinach.
Activation of Cytotoxic Lymphocytes Through CD6 Enhances Killing of Cancer Cells
Authors: Gurrea-Rubio Mikel , Wu Qi , Amin M. Asif , Tsou Pei-Suen , Campbell Phillip L. , Amarista Camila E. , Ikari Yuzo , Brodie William D. , Mattichak Megan N. , Muraoka Sei , Randon Peggy M. , Lind Matthew E. , Ruth Jeffrey H. , Mao-Draayer Yang , Ding Shengli , Shen Xiling , Cooney Laura A. , Lin Feng , Fox David A. 
Published: October 2023

Abstract
Immune checkpoint inhibitors (ICIs) have demonstrated efficacy and improved survival in a growing number of cancers. Despite their success, ICIs are associated with immune-related adverse events that can interfere with their use. Therefore, safer approaches are needed. CD6, expressed by T-lymphocytes and human NK cells, engages in cell-cell interactions by binding to its ligands CD166 (ALCAM) and CD318 (CDCP1). CD6 is a target protein for regulating immune responses and is required for the development of several mouse models of autoimmunity. Interestingly, CD6 is exclusively expressed on immune cells while CD318 is strongly expressed on most cancers. Here we demonstrate that disrupting the CD6-CD318 axis with UMCD6, an anti-CD6 monoclonal antibody, prolongs survival of mice in xenograft models of human breast and prostate cancer, treated with infusions of human lymphocytes. Analysis of tumor-infiltrating immune cells showed that augmentation of lymphocyte cytotoxicity by UMCD6 is due to effects of this antibody on NK, NKT and CD8+ T cells. Tumor-infiltrating cytotoxic lymphocytes were found in higher proportions and were activated in UMCD6-treated mice compared to controls. Similar changes in gene expression were observed by RNA-seq analysis of NK cells treated with UMCD6. Particularly, UMCD6 up-regulated the NKG2D-DAP10 complex and activated PI3K. Thus, the CD6-CD318 axis can regulate the activation state of cytotoxic lymphocytes and their positioning within the tumor microenvironment.
C4 Grasses Employ Various Strategies to Acclimate Rubisco Activase to Heat Stress
Authors: Stainbrook Sarah C , Aubuchon Lindsey N , Chen Amanda , Johnson Emily , Si Audrey , Walton Laila , Ahrendt Angela , Strenkert Daniela , Jez Joseph 
Published: October 2023

Abstract
C4 crops such as Zea mays (maize) and Sorghum bicolor (sorghum) are crucial producers of food and bioenergy. In these crops, carbon assimilation is limited at higher temperatures because the enzyme rubisco activase (RCA), which is responsible for proper function of the CO2 fixing protein rubisco, has been shown to be thermolabile. We present a holistic approach to understand carbon assimilation and RCA function in maize, sorghum, and the C4 model grass Setaria viridis (setaria) during heat stress acclimation. Gas exchange data confirms that assimilation is limited by Ribulose 1,5-bisphosphate (RuBP) carboxylation during heat. Plants express a variety of RCA isoforms and we show that each species changes the isoform expression and proteoform abundances of these variants in different ways. In addition, to understand how changing conditions in the chloroplast stroma affect RCA function during heat, we examined the regulation of RCA activity by thioredoxin F, magnesium ions and adenosine diphosphate. As expected, the activity of RCA is modulated by a combination of these variables, but surprisingly, how these biochemical environment factors affect RCA function differs vastly between species. Unexpected differences are even apparent within a single species: different cultivars of maize show differences in assimilation, proteoform abundance and regulation. Our surprising observation that each grass expresses and regulates RCA differently suggests that even closely related plants use different strategies to maintain RCA function and we conclude that a single reference system cannot accurately reflect protein function in every cultivar.
Water absorption and 3D expansion of different injectable hyaluronic acids
Authors: Paulino Patrícia , Santos Virgínia , Silva Neusa , Mata António , Cruz Mariana Brito da 
Published: October 2023

Abstract
Hyaluronic acid’s water absorption and expansion capacities define a filler’s ability to lift the tissues. Therefore, studying these properties is essential to better understand filler’s clinical performance. The aim of this study was to evaluate and compare water absorption and expansion (bidimensional and three-dimensional) of five Fillmed fillers (Universal, Fine Lines, Volume, Lips and Lips Soft). Water absorption was measured through swelling ratio 24 hours post-hydration. For two-dimensional expansion, samples were analysed quantitatively and qualitatively, using calibrated photographs, before and two hours after hydration. Three-dimensional volume was evaluated before and immediately after injecting the fillers, and 30 minutes, 2 hours and 24 hours post-injection in ex vivo pig skin. The tissue was scanned with the 3Shape TRIOS scanner and resulting STL files were compared. Group comparisons were analyzed with the one-way ANOVA test, and a p-value ≤ 0,05 was established. Lips showed a statistically higher swelling ratio than other fillers (p < 0,05). Fine Lines had the lowest swelling ratio, even if only statistically significant when compared to Universal (p = 0,021). Fine Lines had a significantly higher initial bidimensional width than all fillers (p < 0,05) except Lips Soft. 24 hours post-injection, Fine Lines had the highest three-dimensional volume, which was statistically higher than Volume’s (p = 0,049). All fillers absorbed water and expanded, with Fine Lines tending to have the highest three-dimensional expansion, despite its lowest viscosity and water absorption. Further studies with larger sample sizes are needed to investigate the influence of other properties over water absorption and expansion.
Postoperative Shunt Failure Following Hemispherectomy in Pediatric Patients with Pre-Existing Hydrocephalus
Authors: Das Nikita , Sharma Akshay , Mann Michael , Gordillo Alan , Desai Ansh , Serletis Demitre , Moosa Ahsan N. , Rammo Richard , Bingaman William 
Published: October 2023

Abstract
Objective:
The risk of hydrocephalus following hemispherectomy for drug resistant epilepsy (DRE) remains high. Patients with pre-existing hydrocephalus pose a post-operative challenge, as maintaining existing shunt patency is necessary but lacks a clearly defined strategy. This study examines incidence and predictors of shunt failure in pediatric hemispherectomy patients with pre-existing ventricular shunts.
Methods:
We performed a retrospective chart review at our center to identify pediatric patients diagnosed with DRE who were treated with ventricular shunt prior to their first hemispherectomy surgery. Demographic and perioperative data were obtained including shunt history, hydrocephalus etiology, epilepsy duration, surgical technique, and postoperative outcomes. Univariate analysis was performed using Fischer’s Exact Test and Pearson Correlation, with Bonferroni correction to a = 0.00625 and a = 0.01, respectively.
Results:
5 of 19 (26.3%) patients identified with ventriculoperitoneal shunting prior to hemispherectomy experienced postoperative shunt malfunction. All 5 of these patients underwent at least 1 shunt revision prior to hemispherectomy, with significant association between pre- and post-hemispherectomy shunt revisions. There was no significant association between post-hemispherectomy shunt failure and valve type, intraoperative shunt alteration, postoperative external ventricular drain placement, hemispherectomy revision, lateralization of shunt relative to resection, postoperative complications, or postoperative aseptic meningitis. There was no significant correlation between number of post-hemispherectomy shunt revisions and age at shunt placement, age at hemispherectomy, epilepsy duration, or shunt duration prior to hemispherectomy.
Conclusions:
Earlier shunt revision surgery may portend a subsequent need for shunt revision following hemispherectomy. These findings may guide neurosurgeons in counseling patients with pre-existing ventricular shunts prior to hemispherectomy surgery.
Sex-steroid hormones and risk of postmenopausal estrogen receptor-positive breast cancer: a case-cohort analysis
Authors: Albers Frances EM , Lou Makayla WC , Dashti S Ghazaleh , Swain Christopher TV , Rinaldi Sabina , Viallon Vivian , Karahalios Amalia , Brown Kristy A , Gunter Marc J , Milne Roger L , English Dallas R , Lynch Brigid M 
Published: October 2023

Abstract
Purpose
Sex-steroid hormones are associated with postmenopausal breast cancer but potential confounding from other biological pathways is rarely considered. We estimated risk ratios for sex-steroid hormone biomarkers in relation to postmenopausal estrogen receptor (ER)-positive breast cancer, while accounting for biomarkers from insulin/insulin-like growth factor-signaling and inflammatory pathways.
Methods
This analysis included 1,208 women from a case-cohort study of postmenopausal breast cancer within the Melbourne Collaborative Cohort Study. Weighted Poisson regression with a robust variance estimator was used to estimate risk ratios (RRs) and 95% confidence intervals (CIs) of postmenopausal ER-positive breast cancer, per doubling plasma concentration of progesterone, estrogens, androgens, and sex hormone binding globulin (SHBG). Analyses included sociodemographic and lifestyle confounders, and other biomarkers identified as potential confounders.
Results
Increased risks of postmenopausal ER-positive breast cancer were observed per doubling plasma concentration of progesterone (RR: 1.22, 95% CI: 1.03 to 1.44), androstenedione (RR: 1.20, 95% CI: 0.99 to 1.45), dehydroepiandrosterone (RR: 1.15, 95% CI: 1.00 to 1.34), total testosterone (RR: 1.11, 95% CI: 0.96 to 1.29), free testosterone (RR: 1.12, 95% CI: 0.98 to 1.28), estrone (RR: 1.21, 95% CI: 0.99 to 1.48), total estradiol (RR: 1.19, 95% CI: 1.02 to 1.39) and free estradiol (RR: 1.22, 95% CI: 1.05 to 1.41). A possible decreased risk was observed for SHBG (RR: 0.83, 95% CI: 0.66 to 1.05).
Conclusion
Progesterone, estrogens and androgens likely increase postmenopausal ER-positive breast cancer risk, whereas SHBG may decrease risk. These findings strengthen the causal evidence surrounding the sex hormone-driven nature of postmenopausal breast cancer.
Spectrophotometric Assessment of Environmental Toxicity of Zineb Fungicide for Sustainability in Agriculture.
Authors: Rana Kanika , Sharma Devender , Chaudhary Akhil , Sharma Shubham , Sharma Nisha , Thakur Maridula , Kumari Meena 
Published: October 2023

Abstract
Sustainable agriculture aims to meet the food needs of the growing world population while ensuring minimal impact on the environment and humans as well as productivity. Although pesticides represent the backbone of the agri-food sector in its endeavor to secure food production, their application is perceived by many as an obstacle to the achievement of sustainability; the main concerns are linked with their adverse effects on human health and the environment. Management of pesticides can corroborate sustainability in agriculture. The presence of pesticides in surface and groundwater has frequently been detected and has led many workers to carry out experimental studies on pesticide adsorption by soils because such studies could provide important information regarding the prediction of pesticide movement in soil and aquifers. A spectrophotometric method has been developed based on the reaction of the zineb with chloranil. The proposed spectrophotometric method has been applied to the determination of zineb in commercial formulation, grains, fruits, vegetables, and spiked water samples, resulting in high recoveries indicating good accuracy and precision of the method employed. The method has also been validated to study the adsorption of zineb on three Indian soils by using the batch-equilibrium technique. The reaction between zineb and chloranil yielded a yellow-colored product in the solution and was extracted using acrylonitrile which showed maximum absorbance at 415 nm. The relationship between the absorbance and concentration of the fungicide has been established and found to be linear in the range of 1.10-15.45 µgmL− 1. The leaching potential has been evaluated from adsorption data in terms of Ground Water Ubiquity Score (GUS) and the values obtained in the range 1.34–1.40 which are less than the standard value i.e., 1.8, classifying it as a non-leacher fungicide.
Cardiovascular and renal diseases in type 2 diabetes patients: 5-year cumulative incidence of the first occurred manifestation and hospitalization cost: a cohort within the French SNDS nationwide claims database
Authors: Blin Patrick , Joubert Michael , Jourdain Patrick , Zaoui Philippe , Guiard Estelle , Sakr Dunia , Dureau-Pournin Caroline , Bernard Marie-Agnès , Lassalle Régis , Thomas-Delecourt Florence , Bineau Sébastien , Moore Nicholas , Droz-Perroteau Cécile 
Published: October 2023

Abstract
Background
Myocardial infarction (MI), stroke, peripheral arterial disease (PAD), heart failure (HF) and chronic kidney disease (CKD) are common cardiovascular renal disease (CVRD) manifestations for type 2 diabetes. The incidence of the first occurring CVRD manifestation and cumulative hospitalization costs of each CVRD manifestation are not well known for type 2 diabetes without CVRD history.
Methods
A cohort study of all type 2 diabetes free of CVRD as of January 1st 2014, was identified and followed-up for 5 years within the French SNDS nationwide claims database. The cumulative incidence of the first occurring CVRD manifestation was estimated using the cumulative incidence function, with death as a competing risk. Cumulative hospitalization costs of each CVRD manifestations were estimated from the perspective of all payers.
Results
From about 2 million type 2 diabetes without cancer or transplantation, 76.5% were free of CVRD at baseline with a mean age of 65 years, 52% of women and 7% with microvascular complications history. The cumulative incidence of a first CVRD manifestation was 15.3% after 5 years of follow-up with a constant linear increase over time for all CVRD manifestations: The most frequent was CKD representing 40.6% of first occurred CVRD manifestation, followed by HF (23.0%), then PAD (13.5%), stroke (13.2%) and MI (9.7%). HF and CKD together reached about one patient out of ten after 5 years and represented 63.6% of first CVRD manifestations. The 5-year global cost of all CVRD hospitalizations was 3.9 billion euros (B€), i.e. 2,450€ per patient of the whole cohort, with an exponential increase over time for each specific CVRD manifestation. The costliest was CKD (2.0 B€), followed by HF (1.2 B€), then PAD (0.7 B€), stroke (0.6 B€) and MI (0.3 B€).
Conclusions/interpretation
While MI, stroke and PAD remain classic major risks of complications for CVRD-free type 2 diabetes, HF and CKD nowadays represent individually a higher risk and cost than each of these classic manifestations, and jointly represents a risk and a cost twice as high as of these three classic manifestations all together. This should encourage the development of specific HF and CKD preventive strategies.