bluuebunny/crossref_metadata_2025_split huggingface dataset:
Long-term follow-up study of necrotising pancreatitis: interventions, complications and quality of life
Authors: Hollemans Robbert A , Timmerhuis Hester C , Besselink Marc G , Bouwense Stefan A W , Bruno Marco , van Duijvendijk Peter , van Geenen Erwin-Jan , Hadithi Muhammed , Hofker Sybrand , Van-Hooft Jeanin E , Kager Liesbeth M , Manusama Eric R , Poley Jan-Werner , Quispel Rutger , Römkens Tessa , van der Schelling George P , Schwartz Matthijs P , Spanier Bernhard W M , Stommel Martijn , Tan Adriaan , Venneman Niels G , Vleggaar Frank , van Wanrooij Roy L J , Bollen Thomas L , Voermans Rogier P , Verdonk Robert C , van Santvoort Hjalmar C 
Published: January 2024

Objective
To describe the long-term consequences of necrotising pancreatitis, including complications, the need for interventions and the quality of life.

Design
Long-term follow-up of a prospective multicentre cohort of 373 necrotising pancreatitis patients (2005–2008) was performed. Patients were prospectively evaluated and received questionnaires. Readmissions (ie, for recurrent or chronic pancreatitis), interventions, pancreatic insufficiency and quality of life were compared between initial treatment groups: conservative, endoscopic/percutaneous drainage alone and necrosectomy. Associations of patient and disease characteristics during index admission with outcomes during follow-up were assessed.

Results
During a median follow-up of 13.5 years (range 12–15.5 years), 97/373 patients (26%) were readmitted for recurrent pancreatitis. Endoscopic or percutaneous drainage was performed in 47/373 patients (13%), of whom 21/47 patients (45%) were initially treated conservatively. Pancreatic necrosectomy or pancreatic surgery was performed in 31/373 patients (8%), without differences between treatment groups. Endocrine insufficiency (126/373 patients; 34%) and exocrine insufficiency (90/373 patients; 38%), developed less often following conservative treatment (p<0.001 and p=0.016, respectively). Quality of life scores did not differ between groups. Pancreatic gland necrosis >50% during initial admission was associated with percutaneous/endoscopic drainage (OR 4.3 (95% CI 1.5 to 12.2)), pancreatic surgery (OR 3.2 (95% CI 1.1 to 9.5) and development of endocrine insufficiency (OR13.1 (95% CI 5.3 to 32.0) and exocrine insufficiency (OR6.1 (95% CI 2.4 to 15.5) during follow-up.

Conclusion
Acute necrotising pancreatitis carries a substantial disease burden during long-term follow-up in terms of recurrent disease, the necessity for interventions and development of pancreatic insufficiency, even when treated conservatively during the index admission. Extensive (>50%) pancreatic parenchymal necrosis seems to be an important predictor of interventions and complications during follow-up.
Literature review of spinal hematoma case reports: causes and outcomes in pediatric, obstetric, neuraxial and pain medicine cases
Authors: Benzon Honorio T , Nelson Ariana M , Patel Arpan G , Chiang Silvia , Agarwal Deepti , Benzon Hubert A , Rozental Jack , McCarthy Robert J 
Published: January 2024

BackgroundThe risk of spinal epidural hematoma (SEH) has been described in the literature but the impact in various patient populations has not been assessed in the same study. We identified the risk factors for SEH and calculated the OR for recovery in the pediatric, adult and obstetric (OB) patients based on the degree of neurological deficit before surgery.MethodsAdult non-OB cases were categorized whether they were on anticoagulants or not; SEH was related to neuraxial or pain procedure; or whether there was adherence to the American Society of Regional Anesthesia (ASRA) guidelines. Eligible cases were identified through PubMed and Embase searches in the English literature from 1954 to July 2022.ResultsA total of 940 cases were evaluated. In the pediatric cases, SEH was typically spontaneous, related to coagulopathy or athletic trauma. OB cases were spontaneous or related to neuraxial injections. Among adults on anticoagulant(s), SEH was mostly spontaneous with no related etiology or related to neuraxial procedure. SEH occurred despite adherence to the ASRA guidelines. Among non-OB adults not on anticoagulants, SEH was due to trauma, neuraxial injections, surgery or other causes. Neurological recovery was related to the degree of neurological deficit before surgery.ConclusionsOur data show a preponderance of spontaneous SEH in all patient populations. SEH developed even though the ASRA guidelines were followed, especially in patients on multiple anticoagulants. Patients with less impairment prior to surgery had a higher likelihood of complete recovery, regardless of the interval between surgery and onset of symptoms.
Fabrication and mechanical characterization of highly preferentially oriented montmorillonite thin films
Authors: Li Yucheng , Chen Yonggui , Liu Li , Zhang Guoping , Ye Weimin , Wang Qiong 
Published: January 2024

This paper presents an experimental protocol developed to prepare highly preferentially oriented montmorillonite thin films, and then to probe with nanoindentation their intrinsic mechanical properties (e.g., Young’s modulus and hardness). Such highly parallel oriented clay thin films were prepared by dispersing varying amounts of montmorillonite powder (e.g., 1–4 g) in deionized water, followed by drying onto silicon wafers. Results indicate that the thin films possess a laminated fabric with a prominent preferred orientation along the basal (00 l) plane. Depth-dependent Young’s modulus and hardness were also observed consistently across different specimens. Specifically, Young’s modulus and hardness of 4.33 and 0.19 GPa, respectively are found at the indentation depth of 100 nm, equivalent to montmorillonite tactoids consisting of ∼80 layers of montmorillonite platelets, respectively.
Petrology and lithogeochemistry of Paleozoic alkalic magmatism in the Selwyn Basin, Yukon, Canada
Authors: Scanlan Emma J. , Leybourne Matthew I. , Layton-Matthews Daniel , Van Wagoner Nancy , Paradis Suzanne , Piercey Steve , Crowley James L. 
Published: January 2024

Alkalic magmatism occurred in the Selwyn Basin, Yukon, Canada throughout the Paleozoic, concurrent with extension during passive margin sedimentation. To examine magmatism associated with this extension, geochemical data were obtained from several locations in the Selwyn Basin (MacMillan Pass, Anvil District, Keno Hill, and the Misty Creek Embayment). Volcanic rocks from the Anvil District and the Misty Creek Embayment are dominated by alkalic basalts with light rare earth element (LREE)-enriched geochemical signatures, whereas metavolcanic and dike samples from Keno Hill comprise subalkaline basalts with enriched mid-ocean ridge basalt (E-MORB) signatures. The Early Ordovician Menzie Creek volcanic rocks of the Anvil District display trace element geochemical signatures intermediate between ocean island basalt (OIB) and E-MORB, whereas the Middle–Late Ordovician volcanic rocks from the Misty Creek Embayment have OIB signatures. Differences in the trace element geochemistry of the sample suites are attributed to the degree of partial melting. The Menzie Creek volcanic rocks formed from large volume melts of enriched mantle that diluted incompatible element signatures in the Early Ordovician. Late Ordovician magmatism produced the Misty Creek Embayment samples, where restricted melt volumes of an enriched mantle source resulted in the most enriched samples geochemically. The Keno Hill samples represent the shallowest melting of the analysed samples and may have resulted from melting of heterogenous subcontinental lithospheric mantle. Magmatic zircons from a Keno Hill metavolcanic sample analysed by chemical abrasion thermal ionization mass spectrometry resulted in a primary deposition age of c. 296 ± 0.36 Ma (Early Permian), during a period with little magmatism in the Selwyn Basin and representing a previously unknown unit in the area.
Computational and experimental approach for investigation of optical properties of single-crystal MnGa2Se4
Authors: Ismayilova N.A. , Asadullayeva S.G. , Musayev M.A. , Askerov D.J. 
Published: January 2024

In the presented work, we propose a systematic investigation of the electronic and optical properties of MnGa2Se4 by combining the spectroscopic ellipsometry carried out at room temperature in the spectral range of 1–4 eV and density functional theory (DFT) calculations. Ellipsometric measurements were collected at an incidence angle between 60° and 75° with a 5° step. The optical direct gap energies of MnGa2Se4 were estimated from the linear extrapolation of the absorption coefficients that were verified by band structure calculation. DFT calculation of the imaginary part ɛ shows that first critical point occurs at 2.46 eV and represents the direct optical transition at Γ point. The total magnetic moment of compound is 3.38 mB. The major contribution in total magnetic moment is due to 3 d state of Mn atoms.
Form factors of decuplet baryons in a covariant quark–diquark approach
Authors: Wang JiaQi , Fu Dongyan , Dong Yubing 
Published: January 2024

AbstractThe electromagnetic and gravitational form factors of decuplet baryons are systematically studied with a covariant quark–diquark approach. The model parameters are firstly discussed and determined through comparison with the lattice calculation results integrally. Then, the electromagnetic properties of the systems including electromagnetic radii, magnetic moments, and electric-quadrupole moments are calculated. The obtained results are in agreement with experimental measurements and the results of other models. Finally, the gravitational form factors and the mechanical properties of the decuplet baryons, such as mass radii, energy densities, and spin distributions, are also calculated and discussed.
The Imipridone ONC213 Targets α-Ketoglutarate Dehydrogenase to Induce Mitochondrial Stress and Suppress Oxidative Phosphorylation in Acute Myeloid Leukemia
Authors: Su Yongwei , Carter Jenna L. , Li Xinyu , Fukuda Yu , Gray Ashley , Lynch John , Edwards Holly , Ma Jun , Schreiner Patrick , Polin Lisa , Kushner Juiwanna , Dzinic Sijana H. , Buck Steven A. , Pruett-Miller Shondra M. , Hege-Hurrish Katie , Robinson Camenzind , Qiao Xinan , Liu Shuang , Wu Shuangshuang , Wang Guan , Li Jing , Allen Joshua E. , Prabhu Varun V. , Schimmer Aaron D. , Joshi Dhananjay , Kalhor-Monfared Shiva , Watson Iain D. G. , Marcellus Richard , Isaac Methvin B. , Al-awar Rima , Taub Jeffrey W. , Lin Hai , Schuetz John D. , Ge Yubin 
Published: January 2024

Abstract

Eradication of acute myeloid leukemia (AML) is therapeutically challenging; many patients succumb to AML despite initially responding to conventional treatments. Here, we showed that the imipridone ONC213 elicits potent antileukemia activity in a subset of AML cell lines and primary patient samples, particularly in leukemia stem cells, while producing negligible toxicity in normal hematopoietic cells. ONC213 suppressed mitochondrial respiration and elevated α-ketoglutarate by suppressing α-ketoglutarate dehydrogenase (αKGDH) activity. Deletion of OGDH, which encodes αKGDH, suppressed AML fitness and impaired oxidative phosphorylation, highlighting the key role for αKGDH inhibition in ONC213-induced death. ONC213 treatment induced a unique mitochondrial stress response and suppressed de novo protein synthesis in AML cells. Additionally, ONC213 reduced the translation of MCL1, which contributed to ONC213-induced apoptosis. Importantly, a patient-derived xenograft from a relapsed AML patient was sensitive to ONC213 in vivo. Collectively, these findings support further development of ONC213 for treating AML.

Significance:
In AML cells, ONC213 suppresses αKGDH, which induces a unique mitochondrial stress response, and reduces MCL1 to decrease oxidative phosphorylation and elicit potent antileukemia activity.
See related commentary by Boët and Sarry, p. 950
How Can It Not Know What It Is?: Remembering Disability as Part of the Whole
Authors: Allegra Indira , Holt Allison Leigh 
Published: January 2024

Abstract
How Can It Not Know What It Is? is a conversation that uses the revered sci-fi film Blade Runner (1982) as a frame to explore the role of memory and affirm disabled identity in collective human experience, specifically concerning technology, the power of self-knowledge, and how these concepts intersect with capitalism and contemporary politics. In an open conversation excerpted here, the artist-authors discuss what it means to be wholly human, navigating subjects from memory to extended cognition, from national mythology to the ethics of AI.
Primitive way country come look inside
Authors: Stienon Ysolde , Tsaplina Marina 
Published: January 2024

Abstract
A disabled poet with Rett syndrome and a disabled performing artist with type 1 diabetes document their 12-month artistic collaboration to illuminate ground-time: the nonverbal, expressive dynamics of embodied communication. Five “communication moments” between the artists (documented in writing, video, and photo) are described. Potentials and limitations of augmentative and alternative communication (AAC) technologies, specifically Tobii Dynavox eye-tracking technology and Communicator 5, are discussed. Additionally, the authors question the clinical diagnostic category of “intellectual disability” on the grounds of disability justice, decolonial science, and philosophy. Communication-assistive technology platform developers are challenged to consider relational embodiment as the foundation of communication in design decisions regarding platform function. Technologies should facilitate improvisation and nonlinear expression—verbal and nonverbal— while maintaining freedom of nondisclosure. The right to opacity in communication is also discussed.
Ricoeur on the Problem of Archaism in the Augustinian Concept of Time
Authors: Hutchens Benjamin 
Published: January 2024

Abstract
This article will explore the role of what Ricoeur calls ‘archaism’ in his work on the third aporia of time in Time and Narrative. Presented in some detail in the conclusion of the third volume, the concept remains undeveloped. In this article we will identify the three characteristics, two forms and three dispositional states (praise, lamentation and hope) that help us to understand it, specifically in the Augustinian context. We have two main goals. We need to see whether there is a problem of origins in the Aristotelian cosmological conception of time as movement and succession and in the Augustinian psychological conception of time in respect of past, present and future against the limit of the Eternal.
Mergers as the Maintenance Mechanism of Cutoff Lows: A Case Study over Europe in July 2021
Authors: Yamamoto Koryu , Iga Keita , Yamazaki Akira 
Published: January 2024

Abstract
A cutoff low that covered central Europe in the middle of July 2021 brought heavy rainfall and severe flooding, resulting in more than 200 fatalities. This low was formed by a trough on 11 July and merged with another cutoff low around 12–13 July. Analysis of the energy budget and potential vorticity suggests that the main cutoff low was maintained through the merger with another cutoff low; this was the dominant contributor to maintenance of the main cutoff low around 12–13 July. The results of Lagrangian trajectory analyses support this conclusion. Analysis of diabatic PV modification during the merger indicates that radiation acts mainly to enhance the potential vorticity of the parcels when they move from another cutoff low into the main cutoff low, especially in the upper layer. However, that effect is not pronounced in the lower layer. These results demonstrate that cutoff lows can be maintained through a merger with another cutoff low and underline the need to consider diabatic processes when investigating mergers.

Significance Statement
This study examines an upper-tropospheric cyclone called a cutoff low, which caused a high-impact weather event over Europe in the middle of July 2021, and investigates its maintenance mechanism. This cutoff low merged with another, suggesting a contribution to the maintenance. Diabatic processes during the merger are also investigated. The results of this study suggest that not only do cyclone regions merge, but diabatic modification of the vortex structure can be seen when two cutoff lows merge, and the modification process may differ in different vertical layers of the cutoff low.
InClust+: the deep generative framework with mask modules for multimodal data integration, imputation, and cross-modal generation
Authors: Wang Lifei , Nie Rui , Miao Xuexia , Cai Yankai , Wang Anqi , Zhang Hanwen , Zhang Jiang , Cai Jun 
Published: January 2024

Abstract
Background
With the development of single-cell technology, many cell traits can be measured. Furthermore, the multi-omics profiling technology could jointly measure two or more traits in a single cell simultaneously. In order to process the various data accumulated rapidly, computational methods for multimodal data integration are needed.

Results
Here, we present inClust+, a deep generative framework for the multi-omics. It’s built on previous inClust that is specific for transcriptome data, and augmented with two mask modules designed for multimodal data processing: an input-mask module in front of the encoder and an output-mask module behind the decoder. InClust+ was first used to integrate scRNA-seq and MERFISH data from similar cell populations, and to impute MERFISH data based on scRNA-seq data. Then, inClust+ was shown to have the capability to integrate the multimodal data (e.g. tri-modal data with gene expression, chromatin accessibility and protein abundance) with batch effect. Finally, inClust+ was used to integrate an unlabeled monomodal scRNA-seq dataset and two labeled multimodal CITE-seq datasets, transfer labels from CITE-seq datasets to scRNA-seq dataset, and generate the missing modality of protein abundance in monomodal scRNA-seq data. In the above examples, the performance of inClust+ is better than or comparable to the most recent tools in the corresponding task.

Conclusions
The inClust+ is a suitable framework for handling multimodal data. Meanwhile, the successful implementation of mask in inClust+ means that it can be applied to other deep learning methods with similar encoder-decoder architecture to broaden the application scope of these models.
Genome-wide identification of B-box zinc finger (BBX) gene family in Medicago sativa and their roles in abiotic stress responses
Authors: Li Shuxia , Guo Shuaiqi , Gao Xueqin , Wang Xiaotong , Liu Yaling , Wang Jing , Li Xiaohong , Zhang Jinqing , Fu Bingzhe 
Published: January 2024

Abstract
Background
B-box (BBX) family is a class of zinc finger transcription factors (TFs) that play essential roles in regulating plant growth, development, as well as abiotic stress. However, no systematic analysis of BBX genes has yet been conducted in alfalfa (Medica go sativa L.), and their functions have not been elucidated up to now.

Results
In this study, 28 MsBBX genes were identified from the alfalfa genome, which were clustered into 4 subfamilies according to an evolutionary tree of BBX proteins. Exon-intron structure and conserved motif analysis reflected the evolutionary conservation of MsBBXs in alfalfa. Collinearity analysis showed that segmental duplication promoted the expansion of the MsBBX family. Analysis of cis-regulatory elements suggested that the MsBBX genes possessed many growth/development-, light-, phytohormone-, and abiotic stress-related elements. MsBBX genes were differentially expressed in leaves, flowers, pre-elongated stems, elongated stems, roots and nodules, and most MsBBXs were remarkably induced by drought, salt and various plant growth regulators (ABA, JA, and SA). Further functional verification demonstrated that overexpressing of the MsBBX11 gene clearly promoted salt tolerance in transgenic Arabidopsis by regulating growth and physiological processes of seedlings.

Conclusions
This research provides insights into further functional research and regulatory mechanisms of MsBBX family genes under abiotic stress of alfalfa.
Genome-wide identification of MAPK family in papaya (Carica papaya) and their involvement in fruit postharvest ripening
Authors: Zhu Shengnan , Mo Yuxing , Yang Yuyao , Liang Shiqi , Xian Shuqi , Deng Zixin , Zhao Miaoyu , Liu Shuyi , Liu Kaidong 
Published: January 2024

Abstract
Background
Papaya (Carica papaya) is an economically important fruit cultivated in the tropical and subtropical regions of China. However, the rapid softening rate after postharvest leads to a short shelf-life and considerable economic losses. Accordingly, understanding the mechanisms underlying fruit postharvest softening will be a reasonable way to maintain fruit quality and extend its shelf-life.

Results
Mitogen-activated protein kinases (MAPKs) are conserved and play essential roles in response to biotic and abiotic stresses. However, the MAPK family remain poorly studied in papaya. Here, a total of nine putative CpMAPK members were identified within papaya genome, and a comprehensive genome-wide characterization of the CpMAPKs was performed, including evolutionary relationships, conserved domains, gene structures, chromosomal locations, cis-regulatory elements and expression profiles in response to phytohormone and antioxidant organic compound treatments during fruit postharvest ripening. Our findings showed that nearly all CpMAPKs harbored the conserved P-loop, C-loop and activation loop domains. Phylogenetic analysis showed that CpMAPK members could be categorized into four groups (A-D), with the members within the same groups displaying high similarity in protein domains and intron–exon organizations. Moreover, a number of cis-acting elements related to hormone signaling, circadian rhythm, or low-temperature stresses were identified in the promoters of CpMAPKs. Notably, gene expression profiles demonstrated that CpMAPKs exhibited various responses to 2-chloroethylphosphonic acid (ethephon), 1-methylcyclopropene (1-MCP) and the combined ascorbic acid (AsA) and chitosan (CTS) treatments during papaya postharvest ripening. Among them, both CpMAPK9 and CpMAPK20 displayed significant induction in papaya flesh by ethephon treatment, and were pronounced inhibition after AsA and CTS treatments at 16 d compared to those of natural ripening control, suggesting that they potentially involve in fruit postharvest ripening through ethylene signaling pathway or modulating cell wall metabolism.

Conclusion
This study will provide some valuable insights into future functional characterization of CpMAPKs, and hold great potential for further understanding the molecular mechanisms underlying papaya fruit postharvest ripening.