bluuebunny/crossref_metadata_2025_split huggingface dataset:
Platelet activation relieves liver portal hypertension via the lymphatic system though the classical vascular endothelial growth factor receptor 3 signaling pathway
Authors: Chen Min , Zhao Jin-Bo , Wu Guang-Bo , Wu Zheng-Hao , Luo Gu-Qing , Zhao Zhi-Feng , Zhang Chi-Hao , Lin Jia-Yun , Li Hong-Jie , Qi Xiao-Liang , Huo Hai-Zhong , Tuersun Abudukadier , Fan Qiang , Zheng Lei , Luo Meng 
Published: February 2025

BACKGROUND
Liver cirrhosis and portal hypertension (PHT) can lead to lymphatic abnormalities and coagulation dysfunction. Because lymphangiogenesis may relieve liver cirrhosis and PHT, the present study investigated the gene expression alterations in the lymphatic system and the effectiveness of platelet-mediated lymphangiogenesis in improving liver cirrhosis and PHT.
AIM
To investigate the role of lymphangiogenesis in preclinical PHT models.
METHODS
Immunohistochemistry and transcriptome sequencing of bile duct ligation (BDL) and control lymphatic samples were conducted to reveal the indicated signaling pathways. Functional enrichment analyses were performed on the differentially expressed genes and hub genes. Adenoviral infection of vascular endothelial growth factor C (VEGF-C), platelet-rich plasma (PRP), and VEGF3 receptor (VEGFR) inhibitor MAZ-51 was used as an intervention for the lymphatic system in PHT models. Histology, hemodynamic tests and western blot analyses were performed to demonstrate the effects of lymphatic intervention in PHT patients.
RESULTS
Lymphangiogenesis was increased in the BDL rat model. Transcriptome sequencing analysis of the extrahepatic lymphatic system revealed its close association with platelet adherence, aggregation, and activation. The role of PHT in the rat model was investigated by activating (PRP) and inhibiting (MAZ-51) the lymphatic system. PRP promoted lymphangiogenesis, which increased lymphatic drainage, alleviated portal pressure, reduced liver fibrosis, inhibited inflammation, inhibited angiogenesis, and suppressed mesenteric artery remodeling. MAZ-51 reversed the above improvements.
CONCLUSION
Via VEGF-C/VEGFR-3, platelets impede fibrosis, angiogenesis, and mesenteric artery remodeling, ultimately alleviating PHT. Thus, platelet intervention is a therapeutic approach for cirrhosis and PHT.
SEL1L-mediated endoplasmic reticulum associated degradation inhibition suppresses proliferation and migration in Huh7 hepatocellular carcinoma cells
Authors: Chen Jia-Nan , Wang Li , He Yu-Xin , Sun Xiao-Wei , Cheng Long-Jiao , Li Ya-Nan , Yoshida Sei , Shen Zhong-Yang 
Published: February 2025

BACKGROUND
Proteins play a central role in regulating biological functions, and various pathways regulate their synthesis and secretion. Endoplasmic reticulum-associated protein degradation (ERAD) is crucial for monitoring protein synthesis and processing unfolded or misfolded proteins in actively growing tumor cells. However, the role of the multiple ERAD complexes in liver cancer remains unclear.
AIM
To elucidate the effects of SEL1L -mediated ERAD on Huh7 and explore the underlying mechanisms in vivo and in vitro .
METHODS
Huh7 cells were treated with ERAD inhibitor to identify ERAD’s role. Cell counting kit-8, 5-ethynyl-2’-deoxyuridine and colony formation experiments were performed. Apoptosis level and migration ability were assessed using fluorescence activated cell sorting and Transwell assay, respectively. Huh7 SEL1L knockout cell line was established via clustered regularly interspaced short palindromic repeats, proliferation, apoptosis, and migration were assessed through previous experiments. The role of SEL1L in vivo and the downstream target of SEL1L were identified using Xenograft and mass spectrometry, respectively.
RESULTS
The ERAD inhibitor suppressed cell proliferation and migration and promoted apoptosis. SEL1L -HRD1 significantly influenced Huh7 cell growth. SEL1L knockout suppressed tumor cell proliferation and migration and enhanced apoptosis. Mass spectrometry revealed EXT2 is a primary substrate of ERAD. SEL1L knockout significantly increased the protein expression of EXT2 . Furthermore, EXT2 knockdown partially restored the effect of SEL1L knockout.
CONCLUSION
ERAD inhibition suppressed the proliferation and migration of Huh7 and promoted its apoptosis. EXT2 plays an important role and ERAD might be a potential treatment for Huh7 hepatocellular carcinoma.
Unpredictable singleton distractors in visual search can be subject to second-order suppression
Authors: Drisdelle Brandi Lee , Zivony Alon , Eimer Martin 
Published: February 2025

Abstract
Recent evidence suggests that attentional capture by salient-but-irrelevant distractions can be avoided via suppression, thereby improving performance in visual search. Initial evidence suggested it is only possible to suppress salient distractors with constant and predictable features (first-order suppression). We show that previous failures to find evidence for second-order suppression of unpredictable feature singletons may have been due to low feature variability: If it is probable that the salient distractor colour is the target colour on another trial, suppressing this item might hinder performance. We first validated a new multiframe letter-probe paradigm, where observers counted the search displays with a target shape and always reported as many letter probes as possible from the final display. When target and singleton colours were constant (Experiment 1), a singleton suppression effect was observed, with probe letters at the singleton distractor location reported less frequently than those at non-singleton distractor locations. When two randomly swapped target/singleton colours were employed (Experiment 2), no suppression effect was observed, replicating previous findings. Critically, when target-colour items and the singleton could have one of eight different random colours (Experiment 3), a robust suppression effect reappeared. These observations demonstrate that first-order suppression is not universal, and that second-order suppression can be applied to singleton distractors under some circumstances. Suppression effects were observed for displays with and without targets, suggesting that they are not a product of direct target-singleton competition.
The Influence of Job Stress and Work Culture on the Perfomance of Employees at Company, Bandung City
Authors: Cahyati Peni , Maria Elvie , Limakrisna Nandan , Mulyatini Nurdiana , Gunawan M April 
Published: February 2025

The objective of this research is to determine the impact of work-related stress on the performance of employees at The X Company firm. (2) This study examines the impact of work culture on employee performance at The X Company company. (3) Additionally, it investigates the role of job stress on work culture at The X Company company. (4) This study examines the impact of job stress and work culture on employee performance at The X Company enterprise. The research was conducted at the companyInvestama's facility, X Company. A study was done at Investama's firm, X Company, with a sample size of 30 individuals. The data utilized in this study consist of primary data and secondary data. Data collecting methods include techniques such as document recording, interviews, and surveys. For doing data analysis using route analysis. The findings of this study indicate that job stress and work culture have a favorable impact on employee performance at The X Company organization. (2) Work stress has a beneficial impact on the work culture at The X Company firm. (3) Work stress has a favorable impact on staff performance at The X Company firm. (4) The work culture of The X Company organization has a beneficial impact on staff performance.
New Stellar Parameters, Metallicities, and Elemental Abundance Ratios for 311 Metal-poor Stars
Authors: Mittal Sanil , Roederer Ian U. 
Published: February 2025

Abstract
We present equivalent widths, improved model atmosphere parameters, and revised abundances for 14 species of 11 elements derived from high-resolution optical spectroscopy of 311 metal-poor stars. All of these stars had their parameters previously published by Roederer et al. We use color–T
eff relationships calibrated for Gaia and 2MASS photometry to calculate improved effective temperatures (T
eff). We calculate log of surface gravity (log g) values using measurements derived from Gaia parallaxes and other fundamental stellar properties. We perform a standard LTE abundance analysis using MARCS model atmospheres and the MOOG line analysis software to rederive microturbulence velocity parameters, metallicities, and abundances based on O i, Na i, Mg i, Si i, K i, Ca i, Ti i, Ti ii, Cr i, Cr ii, Fe i, Fe ii, Ni i, and Zn i lines using previously measured equivalent widths. On average, the new T
eff values are 310 K warmer, the new log g values are higher by 0.64 dex, and the new [Fe/H] values are higher by 0.26 dex. We apply NLTE corrections to the abundances derived from O i, Na i, Mg i, Si i, K i, Fe i, and Fe ii lines. Our sample contains 6 stars with [Fe/H] < −3.5, 28 stars with [Fe/H] < −3.0, and 113 stars with [Fe/H] < −2.5. Our revised abundances for these 311 stars are now in better agreement with those derived by previous studies of smaller samples of metal-poor stars in the Milky Way.
Probing Three-dimensional Magnetic Fields. IV. Synchrotron Polarization Derivative and Vision Transformer
Authors: Hu Yue , Lazarian Alex 
Published: February 2025

Abstract
Measuring the 3D spatial distribution of magnetic fields in the interstellar medium and the intracluster medium is crucial yet challenging. The probing of the 3D magnetic field’s 3D distribution, including the field plane-of-sky orientation (ψ), the magnetic field’s inclination angle (γ) relative to the line of sight, and the magnetization (∼the inverse Alfvén Mach number

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), at different distances from the observer makes the task even more formidable. However, the anisotropy and Faraday decorrelation effect in polarized synchrotron emission offer a unique solution. We show that due to the Faraday decorrelation, only regions up to a certain effective path length along the line of sight contribute to the statistical correlation of the measured polarization. The 3D spatial information can be consequently derived from synchrotron polarization derivatives (SPDs), which are calculated from the difference in synchrotron polarization across two wavelengths. We find that the 3D magnetic field can be estimated from the anisotropy observed in SPDs: the elongation direction of the SPD structures probes ψ, and the degree of SPD anisotropy, along with its morphological curvature, provides insights into

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and γ. To extract these anisotropic features and their correlation with the 3D magnetic field, we propose utilizing a machine learning approach, specifically the Vision Transformer (ViT) architecture, which was exemplified by the success of ChatGPT. We train the ViT using synthetic synchrotron observations generated from magnetohydrodynamic turbulence simulations in sub-Alfvénic and super-Alfvénic conditions. We show that ViT’s application to multiwavelength SPDs can successfully reconstruct the 3D magnetic fields’ 3D spatial distribution.
Multimission Observations of Relativistic Electrons and High-speed Jets Linked to Shock-generated Transients
Authors: Raptis Savvas , Lindberg Martin , Liu Terry Z. , Turner Drew L. , Lalti Ahmad , Zhou Yufei , Kajdič Primož , Kouloumvakos Athanasios , Sibeck David G. , Vuorinen Laura , Michael Adam , Shumko Mykhaylo , Osmane Adnane , Krämer Eva , Turc Lucile , Karlsson Tomas , Katsavrias Christos , Wilson Lynn B. , Madanian Hadi , Blanco-Cano Xóchitl , Cohen Ian J. , Escoubet C. Philippe 
Published: February 2025

Abstract
Shock-generated transients, such as hot flow anomalies (HFAs), upstream of planetary bow shocks, play a critical role in electron acceleration. Using multimission data from NASA’s Magnetospheric Multiscale and ESA’s Cluster missions, we demonstrate the transmission of HFAs through Earth’s quasi-parallel bow shock, accelerating electrons to relativistic energies in the process. Energetic electrons initially accelerated upstream are shown to remain broadly confined within the transmitted transient structures downstream, where they get further energized due to the elevated compression levels potentially by betatron acceleration. Additionally, high-speed jets form at the compressive edges of HFAs, exhibiting a significant increase in dynamic pressure and potentially contributing to further localized compression. Our findings emphasize the efficiency of quasi-parallel shocks in driving particle acceleration far beyond the immediate shock transition region, expanding the acceleration region to a larger spatial domain. Finally, this study underscores the importance of a multiscale observational approach in understanding the convoluted processes behind collisionless shock physics and their broader implications.
Evaluating perceived advantages and funding needs to enhance emergency medical services: insights from patients and staff
Authors: Dimitrov Valentin , Dimitrova Diana Pantileeva , Vodenicharova Alexandrina , Dzhafer Samir , Papathanasiou Jannis , Dzhafer Nigyar 
Published: February 2025

Introduction: The University Hospital for Active Treatment and Emergency Medicine (UHATEM) “N. I. Pirogov” LTD is a pivotal institution in Bulgaria’s emergency medical services (EMS). However, funding challenges adversely affect its operational efficiency and quality of care.
Aim: This study aims to identify the primary perceived advantages of UHATEM “N. I. Pirogov” LTD compared to other medical facilities, assess differences in perceptions between patients and staff, and evaluate the impact of funding limitations on hospital operations.
Materials and methods: A cross-sectional study was conducted between January and July 2023 using a self-administered online questionnaire with 16 questions across four domains. A total of 1,041 participants were surveyed. Data analysis included descriptive statistics, chi-square tests, Cramér’s V, and one-way ANOVA to identify significant differences in perceptions and mean scores across age groups.
Results: “Fast and fail-safe 24-hour access” was the most valued advantage among both patients and staff. The staff highlighted the hospital’s “multidisciplinary profile and teams” and “unique and unparalleled clinics and structures” as significant strengths. Chi-square analysis confirmed significant associations between perceived advantages and respondent type. Funding-related challenges, such as limited financial resources and high operational costs, were identified as critical issues.
Conclusions: To improve EMS quality and sustainability at UHATEM “N. I. Pirogov” LTD, consistent state funding, public-private partnerships, and operational efficiencies are needed. Addressing these challenges is essential for maintaining high-quality care and operational stability.
Humanismo y filología: las obras de Séneca en la época de Juan II de Castilla (y una mirada a la corte aragonesa de Nápoles)
Authors: Zinato Andrea 
Published: February 2025

El artículo trata de la importancia de las cortes reales, sobre todo las de Juan II de Castilla y de Alfonso V de Aragón, para la recuperación de las obras de Séneca en latín y en traducción. En el Nápoles aragonés, al amparo del magisteriumpolítico-intelectual de los humanistas italianos vinculados con la corte aragonesa, el pensamiento filosófico senequiano se convirtió en un componente de cierto peso para la utilización de la herencia clásica en la gestión de la res publica y la formación de la biblioteca real como instrumentum regni. En la corte castellana el usufructo de la lectio Senecae siguió acomodándose a lo postulado por Alfonso de Cartagena en el prólogo a sus traducciones de los libros de Séneca, es decir, a la necesidad de una interpretación escolástica y profesional para bien entender sus escritos, especialmente en lo referido a cuestiones éticas y dialécticas sensibles.
Diego de Valera y la Crónica de Juan II
Authors: Moya García Cristina 
Published: February 2025

Desde la impresión de 1517 de la Crónica de Juan II, el nombre de Diego de Valera ha estado ligado a esta crónica real. Diferentes episodios de la vida de Valera en ella contenidos junto con la inclusión de las dos epístolas que envió al rey, han hecho pensar que pudo participar, de alguna forma, en la redacción de la crónica del padre de Isabel la Católica. No obstante, unas palabras del escritor en la Valeriana parecían desmentirlo. En este trabajo se demuestra que Valera conoció tanto la Primera parte de la Crónica de Juan II como la Refundición, editada por Galíndez de Carvajal. Además, se muestran una serie de pruebas textuales que evidencian que hubo de intervenir en el texto de la Crónica de Juan II que salió de las prensas de Arnao Guillén de Brocar. Se ofrece también una teoría de cuándo pudo ocuparse de esta crónica.
Sur la mesure du réalisme dans les images de synthèse. Des expériences de la boîte de Cornell au photoréalisme d’Inception et d’ImageNet
Authors: Eriksson Maria 
Published: February 2025

À l’instar du domaine plus ancien de l’imagerie de synthèse, l’un des principaux objectifs du développement des modèles génératifs d’images a été d’atteindre au photoréalisme, c’est-à-dire de fabriquer des images indiscernables de celles produites au moyen d’un véritable appareil photo. Cet article situe les techniques actuelles d’évaluation du photoréalisme appliquées aux images de synthèse à l’intérieur d’une histoire plus longue des efforts déployés pour évaluer le réalisme des contenus générés par ordinateur. Plus précisément, la métrique FID et l’Inception Score, deux techniques d’évaluation du photoréalisme dans les images générées par l’intelligence artificielle (IA) couramment employées aujourd’hui, sont comparées avec les méthodes d’évaluation tirées des expériences de la boîte de Cornell, une compilation de techniques qui ont servi de modèles sur la façon d’évaluer le réalisme dans les images générées par ordinateur à partir des années 1980. En explorant la manière dont les idées de réalisme et de photoréalisme sont traduites en modèles algorithmiques, et en se basant sur les travaux de Lev Manovich et Hannes Bajohr, on observe un tournant dans la mise en œuvre du photoréalisme, qui de séquentielle et simulative est devenue prédictive et connexionniste à compter de la période comprise entre 2014 et 2016. Cet article démontre également la façon dont un ensemble de données d’entraînement d’IA (ImageNet) et un réseau de neurones (le modèle Inception) ont contribué de façon décisive à façonner l’esthétique du photoréalisme dans le domaine de la création d’images de synthèse depuis 2016.
Images nettes, masques flous
Authors: Heilmann Till A. 
Published: February 2025

De nos jours, la quasi-totalité des images – des photos prises sur smartphone aux publicités de magazines – est optimisée par des algorithmes, ce qui contribue à redéfinir les standards esthétiques et notre perception de ce qui constitue une « bonne » image. La netteté est devenue le réglage par défaut de la culture photographique quotidienne. Cet article étudie la généalogie du masque flou, ou « unsharp masking », une méthode d’amélioration d’image popularisée par Adobe Photoshop. Initialement conçu comme une technique « analogique » destinée à empêcher la perte d’information lors de la reproduction d’originaux à contraste élevé, le masque flou a vu sa finalité passer de la conservation des détails à l’accentuation du piqué – c’est-à-dire l’impression de netteté. Cette transition reflète sa transformation d’un outil employé dans des domaines spécialisés tels que la radiographie et l’astrophotographie à un procédé d’optimisation universel dans la chaîne de traitement des images numériques. Fonction aujourd’hui banalisée et largement automatisée, le masque flou exerce une influence profonde sur la culture visuelle.
Les images de synthèse photoréalistes, entre exigence de réalisme et viabilité économique. Le cas du facteur de flare
Authors: Schröter Jens 
Published: February 2025

Depuis les années 1970, la quête du photoréalisme constitue le moteur de l’imagerie de synthèse. Le but du photoréalisme n’est pas uniquement d’obtenir des rendus « réalistes », mais plus précisément de générer des images qui semblent avoir été photographiées. Cette aspiration concernait initialement l’intégration de scènes en images de synthèse dans des films réalisés par ailleurs avec des moyens photographiques. Produire des images ressemblant à des photographies signifie également reproduire des effets caractéristiques des procédés photographiques, comme différents types de flous et d’aberrations spécifiques tels que le facteur de flare. La simulation du flare constitue le sujet de cet essai qui, à travers l’analyse approfondie d’un article de recherche en informatique, tend à démontrer que les procédés de simulation de la photographie se heurtent systématiquement à deux objectifs concurrents : d’une part la simulation d’une propriété photographique donnée – ici le facteur de flare – de manière réaliste sur le plan physique, opération susceptible de nécessiter des ressources computationnelles considérables et beaucoup de temps ; d’autre part l’exigence économique d’obtenir un rendu efficient à moindre coût.
Dissiper le brouillard. Les premiers traitements d’images et le système d’imagerie lunaire Surveyor (1966‑1968)
Authors: Cullen Frances 
Published: February 2025

Au cours des années 1960, la National Aeronautics and Space Administration (NASA) a consacré une partie de ses vastes ressources à la mise au point de techniques informatiques novatrices, destinées à améliorer et à mettre en valeur ses images astronomiques. Cet article met en lumière ce premier chapitre de l’histoire de l’image algorithmique en décrivant les circonstances de l’intégration de cette technologie dans le système d’imagerie d’un programme spécifique de la NASA : la mission Surveyor (1966-1968). Dans le cadre de ce programme, les photographies de la surface lunaire ont été saisies à l’aide d’une caméra de télévision, transmises sur Terre par télémétrie, puis diffusées à l’aide de technologies impliquant des bandes magnétiques, divers formats de pellicules et diverses techniques de traitement manuel et informatisé. Cet article montre comment, lorsqu’elles ont été intégrées dans ce système d’imagerie déjà complexe et diversifié, ces nouvelles techniques de traitement des images ont en quelque sorte fonctionné comme une chambre noire étendue, reproduisant et complétant, pour l’essentiel, une logique déjà existante d’extraction et de traitement de l’information.
Entre la photographie et le photogramme. Le destin de l’image unique à l’ère des algorithmes
Authors: Grespi Barbara 
Published: February 2025

L’utilisation d’algorithmes de deep learning dans la production de photographies a remis en question une notion essentielle au sein des images médiatiques : la distinction entre photographie et photogramme. La théorie a souvent souligné l’importance de la non-coïncidence de ces deux modes du photographique : le premier étant autonome, unique et fini ; le deuxième incomplet et dépourvu de sa propre visibilité. Mais aujourd’hui, l’intervention d’algorithmes au moment de la capture de l’image vient atténuer cette distinction. De fait, un simple cliché photographique est désormais une concentration « verticale » de plusieurs images, tandis qu’une photographie en apparence fixe peut dissimuler une série « horizontale » d’images qui permettent aussi de la regarder comme un clip vidéo. En présence de ces images « épaisses », qui ne correspondent plus à la perception humaine et convoquent une dialectique bien différente – entre trace et visualisation, singulier et pluriel, instantané et série –, est-il encore pertinent d’assimiler l’objet photographique et le matériau photogrammatique utilisés au sein de nombreux types d’imageries ? Ne conviendrait-il pas plutôt de redéfinir la photographie comme un processus génétiquement sériel ?