bluuebunny/crossref_metadata_2025_split huggingface dataset:
Limits to sustained energy intake. XXXIV. Can the heat dissipation limit (HDL) theory explain reproductive aging?
Authors: Grosiak Marta , Koteja Paweł , Hambly Catherine , Speakman John R. , Sadowska Edyta T. 
Published: January 2024

ABSTRACT
According to the heat dissipation limit (HDL) theory, reproductive performance is limited by the capacity to dissipate excess heat. We tested the novel hypotheses that (1) the age-related decline in reproductive performance is due to an age-related decrease of heat dissipation capacity and (2) the limiting mechanism is more severe in animals with high metabolic rates. We used bank voles (Myodes glareolus) from lines selected for high swim-induced aerobic metabolic rate, which have also increased basal metabolic rate, and unselected control lines. Adult females from three age classes – young (4 months), middle-aged (9 months) and old (16 months) – were maintained at room temperature (20°C), and half of the lactating females were shaved to increase heat dissipation capacity. Old females from both selection lines had a decreased litter size, mass and growth rate. The peak-lactation average daily metabolic rate was higher in shaved than in unshaved mothers, and this difference was more profound among old than young and middle-aged voles (P=0.02). In females with large litters, milk production tended to be higher in shaved (least squares mean, LSM±s.e.: 73.0±4.74 kJ day−1) than in unshaved voles (61.8±4.78 kJ day−1; P=0.05), but there was no significan"t effect of fur removal on the growth rate [4.47±2.29 g (4 days−1); P=0.45]. The results provide mixed support of the HDL theory and no support for the hypotheses linking the differences in reproductive aging with either a deterioration in thermoregulatory capability or genetically based differences in metabolic rate.
Hybrid Value Function Approximation for Solving the Technician Routing Problem with Stochastic Repair Requests
Authors: Pham Dai T. , Kiesmüller Gudrun P. 
Published: January 2024

We investigate the combined planning problem involving the routing of technicians and the stocking of spare parts for servicing geographically distributed repair tasks. The problem incorporates many operational uncertainties, such as future repair requests and the required spare parts to replace malfunctioned components. We model the problem as a sequential decision problem where decisions are made at the end of each day about the next day’s technician route and spare part inventory in the van. We show that exact methods are intractable because of the inherent high-dimensional state, decision, and transition spaces involved. To overcome these challenges, we present two novel algorithmic techniques. First, we suggest a hybrid value function approximation method that combines a genetic search with a graph neural network capable of reasoning, learning, and decision making in high-dimensional, discrete decision spaces. Second, we introduce a unique state-encoding method that employs multiattribute graphs and spatial markers, eliminating the need for manually designed basis functions and allowing efficient learning. We illustrate the general adaptive learning capacity by solving a variety of instance settings without instance-specific hyperparameter tuning. An extensive numerical study demonstrates that our hybrid learning technique outperforms other benchmark policies and adapts well to changes in the environment. We also generate a wide range of insights that not only shed light on the algorithmic components but also offer guidance on how to execute on-site repair tasks more efficiently. The techniques showcased are versatile and hold potential for application in other dynamic and stochastic problems, particularly in the realm of transportation planning. Funding: This work was supported by Deutsche Forschungsgemeinschaft (DFG). The Research Training Group 2201 [Grant 277991500], “Advanced Optimization in a Networked Economy,” funded by the DFG, has provided partial support for this work. Supplemental Material: The online appendix is available at https://doi.org/10.1287/trsc.2022.0434 .
Inetetamab combined with tegafur as second-line treatment for human epidermal growth factor receptor-2-positive gastric cancer: A case report
Authors: Zhou Jing-Hao , Yi Qi-Jun , Li Ming-Yan , Xu Yan , Dong Qi , Wang Cong-Ying , Liu Hai-Yan 
Published: January 2024

BACKGROUND
Human epidermal growth factor receptor-2 (HER-2) plays a vital role in tumor cell proliferation and metastasis. However, the prognosis of HER2-positive gastric cancer is poor. Inetetamab, a novel anti-HER2 targeting drug independently developed in China, exhibits more potent antibody-dependent cell-mediated cytotoxicity than trastuzumab, which is administered as the first-line treatment for HER2-positive gastric cancer in combination with chemotherapy. In this case, the efficacy and safety of inetetamab combined with tegafur was investigated as a second-line treatment for HER2-positive gastric cancer.
CASE SUMMARY
A 52-year-old male patient with HER2-positive gastric cancer presented with abdominal distension, poor appetite, and fatigue two years after receiving six cycles of oxaliplatin combined with tegafur as first-line treatment after surgery, followed by tegafur monotherapy for six months. The patient was diagnosed with postoperative recurrence of gastric adenocarcinoma. He received 17 cycles of a combination of inetetamab, an innovative domestically developed anti-HER2 monoclonal antibody, and tegafur chemotherapy as the second-line treatment (inetetamab 200 mg on day 1, every 3 wk combined with tegafur twice daily on days 1–14, every 3 wk). Evaluation of the efficacy of the second-line treatment revealed that the patient achieved a stable condition and progression-free survival of 17 months. He tolerated the treatment well without exhibiting any grade 3-4 adverse events.
CONCLUSION
Inetetamab combined with chemotherapy for the treatment of metastatic HER2-positive gastric cancer demonstrates significant survival benefits and acceptable safety.
STRUCTURAL STUDY OF POWDER LIGNOCELLULOSE CONTAINING SILVER BY COMPUTER SIMULATION OF ATOMIC STRUCTURE
Authors: Gromyko Dar'ya Valer'yevna , Prusskiy Andrey Ivanovich , Tokko Ol'ga Vladimirovna , Kotelnikova Nina Efimovna 
Published: January 2024

The structure of silver modified powder cellulose isolated from hardwood lignocellulose was investigated using X-ray structural analysis and computer modeling. Full-profile analysis proved that the studied sample corresponds to the monoclinic phase of cellulose Iβ with an antiparallel arrangement of molecules. The unit cell parameters were a = 7.881 Å, b = 7.837 Å, c = 10.603 Å, and γ = 95.63°; the volume V = 652 Å3. The sizes of coherent scattering regions (CSR) of the sample calculated with a Scherrer method were determined to analyze the supramolecular structure. An increase of CSR was observed in the [100] direction and a decrease was found in the [001] direction compared to CSR of the powder lignocellulose. Cross-section area of the fibril of the modified sample in plane ab (980 Å2) was found to be ~8% larger than that of powder cellulose. The crystallinity index (CI) calculated with a Ruland method was found to be 79% which was 7% higher than that of powder cellulose. The final cluster of the silver containing powder cellulose had a chemical formula of C6O5H10.12Ag0.08.
NEW METHODS OF PREPARATION OF ALLOBETULIN 3-O-LACTATE AND ITS PHYSICOCHEMICAL PROPER-TIES
Authors: Skurydina Yevgeniya Sergeyevna , Kuznetsova Svetlana Alekseyevna , Novikova Svetlana Andreevna , Shakhtshneider Tat'yana Petrovna , Kuznetsov Boris Nikolaevich 
Published: January 2024

In this work the new, one-step methods for the synthesis of allobetulin 3-O-lactate from betulin and birch bark were proposed. The composition of the obtained samples of allobetulin 3-O-lactate after recrystallization from ethanol and acetone was determined by elemental analysis, and its structure was confirmed by IR and NMR spectroscopy for the first time. The melting point of allobetulin 3-O-lactate is 225–226 °C. The one-step method for the preparation of allobetulin 3-O-lactate from betulin is based on the combination of the stages of isomerization of betulin in the presence of sulfuric acid and the formation of ester with lactic acid, that does not require an additional stage of allobetulin synthesis. The yield of allobetulin 3-O-lactate is 77 wt%. The one-stage method of obtaining allobetulin 3-O-lactate directly from birch bark is based on combining the stages of betulin extraction, its isomerization into allobetulin and esterification of allobetulin, it allowed to exclude the stages of betulin extraction and allobetulin synthesis. The yield of allobetulin 3-O-lactate is 12% of the mass of absolutely dry birch bark (~32%wt. of betulin contained in it). Taking into account that allobetulin and its derivatives have antibacterial, immunotropic, anti-ulcer and antiviral activity, and lactic acid derivatives show immunomodulatory, anti-inflammatory and antimicrobial activity, it can be expected that allobetulin 3-O-lactate will show improved pharmacological properties compared to the starting substances.
A new enhanced mountain gazelle optimizer and artificial neural network for global optimization of mechanical design problems
Authors: Mehta Pranav , Sait Sadiq M. , Yıldız Betül Sultan , Erdaş Mehmet Umut , Kopar Mehmet , Yıldız Ali Rıza 
Published: January 2024

Abstract
Nature-inspired metaheuristic optimization algorithms have many applications and are more often studied than conventional optimization techniques. This article uses the mountain gazelle optimizer, a recently created algorithm, and artificial neural network to optimize mechanical components in relation to vehicle component optimization. The family formation, territory-building, and food-finding strategies of mountain gazelles serve as the major inspirations for the algorithm. In order to optimize various engineering challenges, the base algorithm (MGO) is hybridized with the Nelder–Mead algorithm (HMGO-NM) in the current work. This considered algorithm was applied to solve four different categories, namely automobile, manufacturing, construction, and mechanical engineering optimization tasks. Moreover, the obtained results are compared in terms of statistics with well-known algorithms. The results and findings show the dominance of the studied algorithm over the rest of the optimizers. This being said the HMGO algorithm can be applied to a common range of applications in various industrial and real-world problems.
Synthesis of some chalcones derivatives series and their antituberculosis activity
Authors: Noviany Noviany , Osman Hasnah , Mohamad Suriyati , Hadi Sutopo , Satria Heri , Buhani Buhani 
Published: January 2024

Abstract
Chalcone is an important biosynthetic precursor, due to the diverse pharmacological activities. The aim of this current study was to synthesize 14 new chalcone derivatives compounds by incorporating p-alkoxyacetophenones with substituted benzaldehydes. Two new series of chalcone derivatives have been synthesized using the alkylation and the base catalysed Claisen-Schmidt condensation. All the synthesized compounds were fully characterized by IR, 1D NMR (1H and 13C NMR) and 2D NMR (COSY, HMQC, HMBC) as well as mass spectrometry analysis. All the synthesized compounds were assayed in vitro for their antituberculosis activities against Mycobacterium tuberculosis strain. Among them, compounds (E)-1-[4-(heptoxy)phenyl]-3-(2-hydroxy-5-bromophenyl)prop-2-en-1-one (5a), (E)-1-[4-(octyloxy)phenyl]-3-(2-hydroxy-5-bromophenyl)prop-2-en-1-one (5b) and (E)-1-[4-(decyloxy)phenyl]-3-(2-hydroxy-5-bromophenyl)prop-2-en-1-one (5d) showed good activities with the lowest MIC value of 12.5 μg/mL.
Experimental and numerical investigations on controlled parameter selection methods for kerosene-fueled scramjet
Authors: Jiao Guiqian , Song Wenyan , Zeng Xianglong , Fu Qiang , Tang Wei , Li Hantao 
Published: January 2024

Abstract
In order to determine the optimal wall pressure location as the controlled parameter for kerosene-fueled scramjet, a combined approach of numerical simulation and experimental analysis was employed. The results indicate that with an increase in the equivalence ratio of kerosene, the combustor exhibits consecutive modes, including pure scramjet mode, dual-mode scramjet mode, dual-mode ramjet mode, and pressure disturbance to the isolator inlet mode. The peak pressure ratios corresponding to the mode transition boundaries are 1.95, 3.26, and 3.57, with respective isolator outlet Mach numbers of 1.62, 1.0, and 0.74. The equivalence ratio corresponding to mode transition increases with an increase in the combustor inlet total temperature. Considering the dynamic characteristics of wall pressures at different locations, the position at x/L = 0.46 demonstrates the best linearity, highest sensitivity, and greater stability. Hence, it is the most suitable choice as the controlled parameter for fuel flow in this kerosene-fueled scramjet.
Energy transitions research: An assessment methodology
Authors: Segura Karen Gabriela Liñán 
Published: January 2024

AbstractMarket rules, changes in regulations for users and producers, technological innovation and economic development are important factors shaping energy transitions. Therefore, explaining energy transitions requires a multidisciplinary insight to investigate these factors. The study of energy transitions faces an analytical and methodological challenge, particularly in communicating trends shaping the energy systems in developing economies. The existing literature is not consistent in identifying these disciplines nor proposing how they can be combined. In this sense, this paper proposes a new and simple methodological path to assess variables and theories. It conceptualizes energy transitions as a co-evolution of two types of systems: system innovation with its roots in evolutionary, institutional economics, science and technology studies (STS); and energy systems with its roots in neoclassical and evolutionary economics. From how to conduct a systematic literature review, to how best integrate theories and the analytical framework in which key questions can be answered, the paper elevates the role of political science, as policies play a prominent role in shaping energy transitions. This paper responds to those who have pointed out that the political economy of energy transitions is a vastly understudied area.
Vicente Alanís, un pintor sevillano en la Baja Extremadura. Revisión a su catálogo de obras.
Authors: Cabezas García Álvaro 
Published: January 2024

Vicente Alanís was the Sevillian painter who most openly derived from late baroque aesthetics into the most typical academicism advocated by the Royal School of the Three Noble Arts, a board in which he held several positions and in which his professional career ended. In 1795 he executed the painting Animas in the parish of Santa María de la Encina and San Juan Bautista, in the town of Burguillos del Cerro, Badajoz. The canvas testifies the aroma of historical thought in a place other than a heart of power at the end of the Old Regime, and shows the importance of the of art ideas and influence trafficking. As a result of this discovery, I have been able to add some other works to his oeuvre.
La contribución arquitectónica de Ventura Vaca en Alburquerque a lo largo del tiempo: nuevas aportaciones y significaciones
Authors: Bargón García Marina 
Published: January 2024

Recently, an architectural project by the architect Ventura Vaca was discovered in the context of the town of Alburquerque, Badajoz. This discovery has significantly expanded our understanding of Ventura Vaca's relevance and influence in a specific geographical region, while enriching our interpretation of his own architectural work.
Furthermore, this research undertakes an incipient analysis of the history of the Casas Consistoriales de Alburquerque, with a focus on the project proposed by Ventura Vaca for this building. This project is considered to be the starting point that gave rise to the final town hall construction, which was carried out by the architect Donato Hernández Ruiz.
Therefore, this study contributes significantly to the existing knowledge about Ventura Vaca, highlighting his crucial role as the driving force behind the transformation of the town of Alburquerque from a rural to an urban society.
Overview of Site Effects and the Application of the 2022 New Zealand NSHM in the Wellington Basin, New Zealand
Authors: Kaiser Anna Elizabeth , Hill Matt P. , de la Torre Chris , Bora Sanjay , Manea Elena , Wotherspoon Liam , Atkinson Gail M. , Lee Robin , Bradley Brendon , Hulsey Anne , Stolte Andrew , Gerstenberger Matt 
Published: January 2024

ABSTRACT
We provide an overview of the treatment of site effects in the New Zealand National Seismic Hazard Model (NZ NSHM), including a case study of basin effects in central Wellington. The NZ NSHM 2022 includes a change in site parameter from subsoil class (NZS class) to VS30. Poor NZ VS30 characterization is a major source of uncertainty in the NSHM; however, advanced site characterization in Wellington allows for in-depth study. First, we construct a regional 3D shear-wave velocity model and maps of site parameters (T0, NZS class, and VS30) for central Wellington. At central city soil sites, we find the ratios of NZ NSHM 2022 hazard spectra with respect to the current equivalent design spectra range from factors of ∼0.8–2.6 (median ∼1.5), depending on local site conditions and spectral period. Strong amplification peaks at 0.5–2 s are observed in central Wellington. Linear site-specific amplifications from multiple methods are compared at 13 stations and are well-defined by both site-to-site residuals and response spectral ratios relative to station POTS. At many deeper soft sites (VS30&lt;300  m/s), strong amplification peaks occur around T0 that are underpredicted by mean ergodic ground-motion model (GMM) predictions. This underprediction is slightly enhanced when using basin-specific Z1.0 as an additional site parameter. Our study highlights outstanding challenges in modeling strong basin response within shallow basins in NSHMs, including the need to consider region- or basin-specific modeling approaches as well as nonlinear effects at high shaking intensities that dominate the hazard. For New Zealand, in general, as illustrated in the Wellington case study, a priority is the further characterization of VS30 (and VS) for the seismic network to better isolate and quantify uncertainties in seismic hazard and allow useful exploration of regional–GMM adjustments and partially nonergodic approaches.
Event study announcement of fraud and abnormal returns of BUMN companies
Authors: Nafisa Umi Zahrotin , Makaryanawati Makaryanawati , Yusoff Haslinda 
Published: January 2024

Abstract This study aims to determine the effect of fraudulent financial reporting of BUMN on abnormal returns. This study is important because most of the research examining these events has been conducted in developed markets. This study uses an event study approach with a window period of five days before and five days after the incident. By using the purposive sampling method, five BUMN companies that were reported to have committed the fraudulent in 2019 was selected in this study. The result shows that the incident of fraudulent financial report announcements does not significantly affect abnormal returns. This finding shows that the investors reaction the fraudulent news be not significant. This concludes that the news of fraudulent BUMN companies is not strong enough to influence investment decisions in the capital market. The results of this study are useful for investors in considering investment decisions in state-owned companies because they have fundamentally strong capital, so investors feel safe to invest. The results of this study contribute to the literature by adding new insights about fraud announcement events in BUMN. The results of this study also support the signal theory concept because investors respond to the second and third events as bad signalsAbstrak Penelitian ini bertujuan untuk mengetahui pengaruh peristiwa pengumuman kecurangan BUMN terhadap abnormal return. Penelitian inipenting untuk dilakukan karena sebagian besar penelitian yang mengkaji peristiwa tersebut dilakukan di pasar negara maju. Penelitian ini menggunakan pendekatan event study dengan periode jendela lima hari sebelum dan lima hari setelah peristiwa. Dengan menggunakan metode purposive sampling, lima perusahaan BUMN yang diberitakan melakukan kecurangan pada tahun 2019 menjadi sampel dalam penelitian ini. Hasilnya menunjukkan bahwa peristiwa pengumuman kecurangan tidak berpengaruh secara signifikan terhadap abnormal return. Temuan ini menunjukkan bahwa reaksi investor atas berita kecurangan tidak signifikan. Artinya berita kecurangan perusahaan BUMN tidak cukup kuat untuk memengaruhi keputusan investasi di pasar modal. Hasil penelitian ini bermanfaat bagi investor dalam mempertimbangkan keputusan investasi di perusahaan BUMN karena memiliki modal yang kuat secara fundamental, sehingga investor merasa aman untuk beinvestasi. Hasil penelitian ini berkontibusi pada literatur dengan menambah wawasan baru tentang peristiwa pengumuman kecurangan di BUMN. Hasil penelitian ini juga mendukung konsep teori sinyal karena investor merespons peristiwa kedua dan ketiga sebagai sinyal buruk
A retrospective and observational study of the adverse drug reactions reported in a tertiary care hospital
Authors: Vemuri Veena Rani 
Published: January 2024

Background: Adverse drug reaction (ADR) is considered a common cause of prolonged hospitalization and death among patients. Pharmacovigilance is essential in the surveillance of adverse drug reactions. The responsibility of a healthcare professional is to report any adverse reaction that occurs with the use of drugs. This helps in providing a database and improving the safety of patients. The aim of the study was to determine the incidence of ADR, assess causality, severity, and preventability of the submitted adverse drug reactions, increase the awareness of preventability of adverse drug reactions in health care professionals by conducting regular workshops on ADR, and document occurrence of a rare ADR.
Methods: A retrospective observational study was conducted to assess the ADR reported to the ADR monitoring Centre, for the past 6 years included in the study. The data were entered into Microsoft excel and analyzed using descriptive statistics. Mean and standard deviation were calculated for the categorical data. Drugs were classified according to the class. Reactions were analyzed using scales and presented in descriptive statistics.
Results: A total of 95 ADR reports were received and reported. These ADRs were associated with a total of 108 drugs that were prescribed- the occurrence of ADRs dominated among females 60% (57). Antimicrobials were causing the highest number of adverse reactions 21 (19.44%) and antituberculosis drugs and radiocontrast media were associated with the following larger number of the ADRs 19 (17.59%). Intravenous at 40% was the most common route related to the development of ADR. The most common ADR caused by antimicrobials was rash (9), antitubercular therapy commonly caused hepatitis, and chills and rigors were more common with radiocontrast media. Most of the reactions observed in the patients were moderate reactions at 52.63% with 3.16% fatal ones.
Conclusions: In this study, the predominant causative drugs associated with ADR were antimicrobials, antitubercular drugs, and radiocontrast media. The number of ADRs reported though was less there was a wide range of drugs causing ADR that were reported which gave a broader spectrum for analysis. There is a requirement for active monitoring of ADRs to understand the occurrence as well as help in prevention.