bluuebunny/crossref_metadata_2025_split huggingface dataset:
Assessment of geneXpert test for diagnosis of pediatric pulmonary tuberculosis
Authors: Roma Km , Shrestha Suvesh Kumar , Bhandari Nirajan , Shah Gaurav Jung , Khetan Shivam 
Published: November 2023

Introduction: Pediatric tuberculosis is an infectious disease and is a leading cause of death in Nepal. The incidence of pediatric TB is a key tool of ongoing transmission of tuberculosis within the community and vital indicator of disease control. Its diagnosis is very much challenging and delay in diagnosis leads to mortality.
Objectives: This study was conducted to assess the utility of the gene Xpert test for diagnosis of pediatric pulmonary tuberculosis.
Methodology: A hospital based prospective study done at Pediatric department of a teaching hospital, Nepalgunj, Banke conducted over a period of 1 year from 1 January 2021 to 31 December 2021 with presumptive diagnosis of pediatric pulmonary tuberculosis. Chi-square test was used to determine the association between categorical variables and a receiver operating curve (ROC) analysis was performed to compare the performance of gene Xpert test with other lab parameters like sputum/gastric lavage sample microscopy for acid fast bacilli, erythrocytic sedimentation rate, Tuberculin test (TT) and chest X-ray.

Results: We enrolled a total of 294 patients in our study. Out of 294 samples 5.1% samples came out to be positive for gene Xpert for MTB. The sputum/gastric lavage samples for AFB showed both sensitivity and specificity of 100%. The tuberculin test showed a sensitivity of 80% and specificity of 37.3%. Chest X-ray showed a sensitivity of 66.7% and specificity of 43.7%. The area under the curve for acid fast bacilli in microscopy, tuberculin test and ESR was found to be 100% (95% CI: 100%-100%), 58.6% (95% CI: 44.9%-72.4%), and 52.6% (95% CI: 37%-68.3%) respectively.

Conclusion: This study highlights the utility of gene Xpert as a good diagnostic tool for rapid diagnosis of pulmonary tuberculosis in pediatric population.
Clinical Characteristics and Mortality Predictors of Acute Respiratory Distress Syndrome Patients in ICU- an Observational Study
Authors: Rajbanshi Lalit Kumar , Arjyal Batsalya 
Published: November 2023

Introduction: Adult respiratory distress syndrome (ARDS) is an inflammatory lung condition characterized by a sudden onset of severe oxygen deficiency, bilateral chest infiltrates, and high morbidity and mortality rates. The causes and prognostic factors for ARDS may vary in tropical regions.
Objective: This study aimed to investigate the causes, clinical characteristics, and outcomes of ARDS patients admitted in ICU.
Methodology: We conducted a prospective observational study involving 92 ARDS patients admitted to the medical and surgical intensive care units of a tertiary care hospital in eastern Nepal from 2021 to 2023. We included patients aged 15 years and above who met all the Berlin criteria for ARDS. Patients with burns, end-stage renal disease, hepatic disease, head injuries, congestive cardiac failure, and postoperative patients were excluded. We assessed demographic parameters, initial clinical presentations, causative agents, ventilation parameters, organ failure during the ICU stay, and factors influencing patient mortality.
Results: Our cohort had a mean age of 45.71 ± 20.02 years, with a predominance of male patients. The majority of patients presented with fever and shortness of breath. Approximately 26.1% had mild ARDS, while 25% had severe ARDS. The initial Sequential Organ Failure Assessment (SOFA) score was 10.11 ± 6.07, with most patients having a lung injury score of less than 2.5. Higher lung injury scores and low PaO2/FiO2 ratios were associated with increased mortality (P<0.05). The overall mortality rate in our study was 33.6%.
Conclusion: Pneumonia emerged as the most common cause of ARDS in our region. Low PaO2/FiO2 ratios and higher lung injury scores significantly influenced ARDS mortality.
Sexual Harassment and its Impact in Females at Workplace in Dhanusha District, Madhesh Province, Nepal
Authors: Jha Lalan , Giri Shree Shyam , Sah Poonam , Kapar Vijay Kumar , Yadav Pramod Kumar 
Published: November 2023

INTRODUCTION: The violence of sexual harassment at workplace is problematic issue in the community for females. It has a direct bearing on the workplace productivity as well as the development of the society. Therefore, this study was conducted to assess the effects of sexual harassment on health and daily performances of female employees.
MATERIALS AND METHODS: Descriptive study was carried out in Dhanusha district of Madhesh province of Nepal from March, 2022 to April 2022. The study was conducted in different organizations (workplace) situated in Dhanusha district which were selected purposely. The sample size was 120 working females. Banks, schools, hospitals, and shopping centres were the selected female working places in this study. Face to face interview was conducted through structured questionnaire for the 120 females who gave the permission for interview.
RESULTS: The present study demonstrated that 61.67 % respondents exhibited to possess the knowledge about sexual harassment however, 38.33% of the female respondents demonstrated to be unaware about sexual harassment at their workplace. Among the total numbers of female participating in the research, 29% of the females had experienced the incidence of sexual harassment. Majority of respondents (25.71%) working efficacy had reduced after being suffered from sexual harassment and 5.71% had changed their job. 5.71% females suffered from headache and body ache, 5.71% suffered from high blood pressure, 22.86% suffered from anorexia, 20% suffered from restlessness/insomnia, 17.14% suffered from fatigue, 14.29% suffered from anxiety, 11.43% faced depression and 2.86% had lost their body weight.
CONCLUSIONS: Sexual harassment for females at work place affects them physically as well as mentally. Therefore, awareness programme should be conducted time to time and anti-sexual harassment policy should be implemented at workplace.
Роль хронического гастрита в анамнезе при приёме нестероидных противоспалительных средств у больных с остеоартрозом
Authors: Zak M. Yu. 
Published: November 2023

Обстежено 122 хворих з остеоартрозом (ОА), у яких в анамнезі мав місце верифікований хронічний гастрит (ХГ), віці від 42 до 64 років. Групу контролю становили 40 хворих з ОА без супутньої гастродуоденальної патології в анамнезі. Для лікування артралгії призначали мелоксикам у середній дозі (12,5 ± 1,39) мг/доба або німесулид у середній дозі (150 ± 14,91) мг/доба. У результаті дослідження встановлено, що прийом селективних нестероїдних протизапальних засобів (НПЗЗ) у хворих на ХГ в анамнезі в 2,9 раза (Р < 0,03) підвищує ризик розвитку гастропатії й диспепсії порівняно з хворими без супутньої гастродуоденаольної патології. Атрофія слизової оболонки шлунка асоціюється з тенденцією (Р > 0,05) до більш високого ризику розвитку гастропатії. У хворих з ХГ в анамнезі з метою запобігання гастропатії при приймі НПЗЗ доцільно проводити гастропротективну терапію.
Evaluasi Siklus Sinyal Simpang Empat
Authors: Marpaung Rosmauli , Winayati Winayati , Saleh* Alfian 
Published: November 2023

Simpang Jl. Soekarno hatta –Jl. Darma Bakti – Jalan Durian merupakan persimpangan yang mempunyai tingkat kepadatan tinggi terutama pada jam puncak, hal ini terlihat dari panjang antrian. Tujuan penelitian ini adalah untuk mengetahui waktu siklus simpang pada kondisi eksisting dan memberikan rekomendasi perbaikan waktu siklus simpang. Metode yang digunakan untuk analisis kinerja lalu lintas simpang dengan metode Pedoman Kapasitas Jalan Indonesia (PKJI2014). Data primer pada penelitian ini adalah volume lalu lintas, kondisi geometrik simpang, dan waktu siklus. Sedangkan data sekunder pada penelitian ini adalah data jumlah penduduk, data jumlah pertumbuhan kendaraan. Pengambilan data dilakukan satu hari aktif dan satu hari akhir pekan. Hasil analisis yang didapat pada penelitian ini adalah dengan jumlah volume kendaraan yang didapat sebesar 1067 smp/jam, kapasitas simpang (C) 876,18 smp/jam, nilai derajat kejenuhan (DJ) 0,726, tundaan lalulintas (TLL) 41,0 smp/det, tundaan geometri (TG) 3,6 det/skr, tundaan rata-rata (T) 44,6 det/skr. Berdasarkan penelitian dan pembahasan evaluasi siklus sinyal simpang empat studi kasus : jalan soekarno hatta – jalan darma bakti – jalan durian memiliki nilai derajat kejenuhan masing-masing sebesar 0,786. Hal ini menunjukan bahwa volume lalu lintas pada simpang yang bersangkutan dikategorikan pada tingkat pelayanan E dengan karakteristik arus tidak stabil, yang mana kecepatan yang digunakan standar
The study of acute and subchronic oral toxicity of medicinal drug «Enrocolitrim» on laboratory animals
Authors: Abramov S. V. , Balyshev A. V. , Golovin V. V. , Starikov N. M. , Zhuravleva M. S. 
Published: November 2023

Relevance. The results of the study of the oral toxicity of the medicinal product for veterinary use «Enrocolitrim» on laboratory rodents are presented. Studies of acute toxicity in mice and rats with the determination of the hazard class are described, as well as data on the study of subchronic toxicity of the drug for 14 days in laboratory rats are presented.Methods. To determine the acute toxicity of the drug, 36 outbred rats and 50 outbred mice were used. «Enrocolytrim» was administered using an intragastric tube at doses that allow revealing a dose-dependent effect to assess LD50. Toxicity parameters were calculated according to the method of Kerber, Miller and Teintner, the nature and severity of signs of animal intoxication were visually assessed for 14 days. In a subchronic experiment, the study drug «Enrokolitrim» was studied on 40 outbred rats, of which 3 experimental and 1 control groups were formed. During the experiment, the rodents were weighed, signs of intoxication were recorded, and blood samples were taken for morphological and biochemical analyzes. Dead and euthanized animals were subjected to autopsy.Results. The obtained LD50 values with a single oral administration of the drug «Enrocolitrim» to rats and mice allowed it to be assigned the 4th hazard class – lowh–azard substances (GOST 12.1.007-76). In a subchronic 14-day experiment on rats, it was found that the dose of «Enrocolitrim» 1243 mg/kg with intragastric administration is toxic, and doses of 621.5 mg/kg and 248.6 mg/kg are inactive (safe).
Efficiency of the use of extruded fir flour in feeding broiler chickens
Authors: Bagno O. A. , Prokhorov O. N. , Fedotov S. S. , Rassolov S. N. , Schmidt A. А. 
Published: November 2023

Relevance. Needles are a source of various biologically active substances for animals, including vitamins. The needles also contain phytoncides, which contribute to the suppression of pathogenic microflora in the digestive tract. A number of studies have been devoted to the development of technologies for the production of feed additives based on needlesMethodology. The research work was carried out in the experimental poultry house of «Kuzbass Broiler» LLC on broiler chickens of the Ross 308 cross. 820 heads of chickens in four groups were selected for the experiment. The poultry of the control group received complete compound feed (PC), the 1st–3rd experimental groups received extradited fir flour as part of the PC (1.0%, 2.5%, 5.0% of the weight of the compound feed). When selecting broiler chickens in experimental groups and conducting research, the methods of VNIVIP were used.Results. When feeding extruded fir flour in an amount of 2.5% of the feed volume at the stages of growing broiler chickens the highest indicators of their growth were obtained compared to the control: the absolute and average daily body weight gain is more by 5.3%. Safety increased by 1.8%, the European productivity index (EPI) increased by 35.9 units. Chickens spent 6.1% (0.11 kg) less compound feed per 1 kg of gain compared to analogues from the control group.
The prospects of a model exposition in artificial plantations in urbanized territories
Authors: Kalmykova E. V. , Melnik K. A. , Peredrienko A. I. 
Published: November 2023

The main tasks of the ecological potential are to unite the disparate existing elements of plantings and supplement them with new ones. The assimilation of unique plant ecosystems is possible with an integrated approach. The Volgograd region belongs to the dry-steppe zone, the climate is sharply continental, for which the characteristic features are a decrease in natural moisture supply, excess heat, an active wind regime throughout the year and frequent dry winds. The ecological potential of the south of Russia, in particular the Volgograd region, according to the climate Biological efficiency Index (TC) proposed by N.N. Ivanov, is at a low level (TC = 8–12) with unfavorable natural living conditions of the population with a significant lack of moisture, which raises the question of creating multifunctional plantings as a research scientific basis for rational regional environmental policy in optimizing the process of settlement and social sphere, consistent organization of work and recreation, protection of citizensʼ health. Dendrological expositions growing on cadastral plots of the Federal Research Center for Agroecology of the Russian Academy of Sciences have a high ecological potential in urbanized territories.The purpose of the study is to evaluate the prospects of a model exposure of drought–resistant species in artificial plantings.A general analysis of the decorativeness of G Gleditsia triacanthos f. inermis, Rosa canina, Ribes aureum, Ligustrum vulgare, Juniperus sabina was carried out, the variability of the total assessment of decorativeness between species (34.2–36.6) and the total score (177) were established. All the studied species have good drought resistance, which helps the woody plant to use water and nutrients most efficiently in arid regions on chestnut soils with low moisture supply.
Experience using organomineral fertilizer on potatoes
Authors: Prishchepenko E. A. , Safina R. R. , Garipov N. E. 
Published: November 2023

Relevance. Potatoes are one of the most important food crops in the Russian Federation and CIS countries. For the normal growth and development of the potato plant, it is necessary to provide sufficient nutrition elements. The modern direction is the selection of drugs based on natural sources that improve the mineral nutrition of plants and meet environmental requirements, which is relevant.Methods. Determination of the effectiveness of the use of organomineral fertilizer Adgelar for foliar top dressing of potato tubers. The objects of the study were potatoes of the Salsa variety and the organomineral fertilizer Adgelar. The experiment was carried out on gray forest soil.Results. It was revealed that foliar fertilization with Adgelar fertilizer contributed to increasing yields and improving the quality of potato tubers of the Salsa variety. The increase in potato yield was 17.5% at a dose of 0.3 l/ ha, 23.2% at a dose of 0.75 l/ha, 31.0% at a dose of 1.2 l/ha. With the use of fertilizer, the number of tubers increased (from 1 m²) by 16 17.8%, the average mass of commercial tubers (from 1 m²) – by 16.3–34.8% compared to the control. The share of the seed fraction of tubers increased by 1.5–6.2%, food – by 1.1–3.2%. The starch content in the dry matter increased (by 8.2–11%). There was a decrease in vitamin C by 7–18% compared to the control. In the variants with fertilizer in doses of 0.3 l/ha and 1.2 l/ha, nitrate nitrogen was higher by 10 and 49 mg, respectively.
Causas de lumbalgia en trabajadores del proyecto Megamaxi - cuenca en el año 2022
Authors: García Córdova Juan Fernando , Quinde Alvear Angel Giovanny 
Published: November 2023

Introducción: Este artículo investigativo, realizado en el proyecto Megamaxi – Paraíso de la ciudad de Cuenca, fue realizado en un total de 94 sujetos, caracterizados por rondar la edad entre los 30 y 60 años, con predominio de sobrepeso y obesidad en un 69% de los trabajadores. Objetivos: El objetivo de este es determinar la relación existente entre la posición normal de la columna lumbar y los factores de riesgo tales como: Cargas pesadas, posiciones Forzadas y el uso de herramientas vibratorias. Metodología: El método de estudio realizado es el Cuantitativo, exploratorio, descriptivo, correlacional y no experimental; los resultados obtenidos demuestran una relación positiva entre las variables cargas pesadas y la posición normal de la columna lumbar. Resultados: Según la prueba de Spearman, la relación de estos 2 elementos fue de -544**, lo que nos indica que tenemos un resultado de correlaciones no paramétricas, debido a la relación entre solo una variable con la posición lumbar. Conclusiones: En conclusión, se puede conocer que hay una mayor relación de las cargas pesadas con la aparición de lumbalgia en los trabajadores de la construcción. Mientras que la relación entre las posiciones forzadas o el uso de máquinas vibratorias no presentaron resultados significativos, en comparación con el uso de cargas pesadas. Área de estudio general: Medicina ocupacional. Área de estudio específica: Salud y seguridad ocupacional.
Manifestações orais em pacientes portadores de distúrbios alimentares
Authors: Santos José Romário Silva dos , Almeida Maria Thayná Araújo de , Anjos Raíssa Soares dos 
Published: November 2023

Os transtornos alimentares (TA), correspondem a um grupo de transtornos psicopatológicos que afetam a relação dos indivíduos com a alimentação e com seu corpo. Trazendo como consequência hábitos nocivos que resultam em instabilidade emocional, funcional e em casos extremos ao óbito. O dentista tem um papel essencial na prevenção secundária desses transtornos, tendo em vista que a cavidade oral desses pacientes apresenta sinais característicos. Entretanto, apesar da seriedade do tema, devido à falta de treinamento que permita chegar a uma hipótese diagnóstica, uma parcela significativa dos profissionais se mostra inseguros quanto às medidas a serem tomadas. Podendo colaborar, de forma indireta, com agravamento do quadro clínico. Este trabalho, trata-se de uma revisão integrativa com o objetivo de avaliar as manifestações presentes na cavidade oral decorrentes dos transtornos alimentares, anorexia nervosa e bulimia nervosa, bem como trazer uma perspectiva do cirurgião dentista enquanto profissional de saúde acerca de sua importância nesses casos.
ANALISIS FAKTOR-FAKTOR KETIDAKSESUAIAN PELAKSANAAN SOP RETENSI DOKUMEN REKAM MEDIS DI RSU PKU MUHAMMADIYAH ROGOJAMPI TAHUN 2021
Authors: Yanti Riska Devi 
Published: November 2023

RSU PKU Muhammadiyah Rogojampi has retained medical record documents in 2021, but in its implementation there are still obstacles and it is not in accordance with the SOP. The purpose of this study was to determine the factors causing the non-compliance with the implementation of the SOP for the retention of medical record documents at PKU Muhammadiyah Rogojampi General Hospital. This type of research is descriptive with a qualitative approach. Data collection techniques in this study was by interviewing with officers who carried out retention of 7 people and observation techniques. Based on the results of the study, it was found that several causes of discrepancies in the implementation of the SOP for the retention of medical record documents at RSU PKU Muhammadiyah Rogojampi, in terms of the man factors, the number of staff is still lacking, most of the officers with educational backgrounds are not medical recorders, the tenure of the filing officer is less, and the staff is not have never attended training on retention. In terms of machine factors, the scanning process for medical record documents that have been assessed is not carried out, in terms of method factors, there is no policy and retention is not carried out in accordance with SOP, and in terms of material factors there is no special space and shelves for inactive medical record documents.
Keywords: factors;SOP;medical record retention.
PROBLEMA DIAGNOSIS PERITONEAL TUBERKULOSIS PADA WANITA 15 TAHUN
Authors: Wibowo Gunawan Ari 
Published: November 2023

LAPORAN KASUS
Problema Diagnosis Peritoneal Tuberkulosis pada Wanita 15 tahun
Wibowo Gunawan A, Mustika S, Pratomo B, Supriono. 2022. Laporan Kasus : Wanita 15 Tahun dengan Peritoneal TB, Diagnosis dan Penatalaksanaan .Internal Medicine Program, Faculty of Medicine, Brawijaya University.
Abstrak :

Pendahuluan : Peritoneal Tuberkulosis merupakan suatu peradangan peritoneum visceral maupun parietal yang disebabkan oleh kuman mycobacterium tuberculosis. Sampai saat ini diagnosis suatu peritoneal tuberkulosis masih menjadi suatu problema yang cukup sulit, meskipun terapi tuberkulosis peritoneal relatif mudah. Pasien sering datang dengan gejala non spesifik dan terkadang tanpa disertai tuberkulosis paru.

Kasus : Kami melaporkan sebuah kasus seorang wanita muda 15 tahun dengan, batuk kronik ,penurnan berat badan, diare serta asites masif dan memiliki riwayat kontak dengan penderita TB. Pemeriksaan laboratorium didapatkan peningkatan kadar Ca 125, ADA positif namun hasil GEN X pert tidak menunjukan MTB detected Pemeriksaan CXR menunjukan efusi pleura kiri. Kemuadian berdasarkan kondisi klinis pasien kami memberikan terapi peritoneal tuberculosis dan pasien membaik setelah pemberian OAT selama 3 minggu, dan saat kontrol poli pasien sudah dapat beraktivitas seperti sediakala.

Kesimpulan : Diagnosis peritoneal tuberkulosis harus dipertimbangkan pada penderita yang datang dengan keluhan perut begah disertai dengan gejala konstitusional tuberkulosis. Gambaran USG abdomen pada penderita peritoneal tuberculosis dapat berupa penebalan omentum setempat, perlengketan usus, maupun limfadenopati. Pemeriksaan PCR terhadap cairan asites lebih sensitif dari pada pewarnaan Ziehl-Nielsen dalam mendeteksi adanya Mycobacterium tuberculosis. Pada beberapa kasus yang sulit untuk menegakkan diagnosis pasti peritoenal tuberkulosa, terapi anti tuberkulosis ex juvantibus diperkenankan.
Kata Kunci : Peritoneal tuberkulosis
The actin-bundling protein, PLS3, is part of the mechanoresponsive machinery that regulates osteoblast mineralization
Authors: Chin Samantha M. , Unnold-Cofre Carmela , Naismith Teri , Jansen Silvia 
Published: November 2023

Plastin-3 (PLS3) is a calcium-sensitive actin-bundling protein that has recently been linked to the development of childhood-onset osteoporosis. Clinical data suggest that PLS3 mutations lead to a defect in osteoblast function, however the underlying mechanism remains elusive. To investigate the role of PLS3 in bone mineralization, we generated MC3T3-E1 preosteoblast cells that are stably depleted of PLS3. Analysis of osteogenic differentiation of control and PLS3 knockdown (PLS3 KD) cells showed that depletion of PLS3 does not alter the first stage of osteoblast mineralization in which a collagen matrix is deposited, but severely affects the subsequent mineralization of that matrix. During this phase, osteoblasts heavily rely on mechanosensitive signaling pathways to sustain mineral deposition in response to increasing stiffness of the extracellular matrix (ECM). PLS3 prominently localizes to focal adhesions (FAs), which are intricately linked to mechanosensation. In line with this, we observed that depletion of PLS3 rendered osteoblasts unresponsive to changes in ECM stiffness and showed the same cell size, FA lengths and number of FAs when plated on soft (6 kPa) versus stiff (100 kPa) substrates in contrast to control cells, which showed an increased in each of these parameters when plated on 100 kPa substrates. Defective cell spreading of PLS3 KD cells on stiff substrates could be rescued by expression of wildtype PLS3, but not by expression of three PLS3 mutations that were identified in patients with early onset osteoporosis and that have aberrant actin-bundling activity. Altogether, our results show that actin-bundling by PLS3 is part of the mechanosensitive mechanism that promotes osteoblast mineralization and thus begins to elucidate how PLS3 contributes to the development of bone defects such as osteoporosis.