bluuebunny/crossref_metadata_2025_split huggingface dataset:
Vocal Cord Leukoplakia Classification Using Siamese Network Under Small Samples of White Light Endoscopy Images
Authors: You Zhenzhen , Han Botao , Shi Zhenghao , Zhao Minghua , Du Shuangli , Liu Haiqin , Hei Xinhong , Ren Xiaoyong , Yan Yan 
Published: December 2023

AbstractObjectiveAccurate vocal cord leukoplakia classification is instructive for clinical diagnosis and surgical treatment. This article introduces a reliable very deep Siamese network for accurate vocal cord leukoplakia classification.Study DesignA study of a classification network based on a retrospective database.SettingAcademic university and hospital.MethodsThe white light image datasets of vocal cord leukoplakia used in this article were classified into 6 classes: normal tissues, inflammatory keratosis, mild dysplasia, moderate dysplasia, severe dysplasia, and squamous cell carcinoma. The classification performance was assessed by comparing it with 6 classical deep learning models, including AlexNet, VGG Net, Google Inception, ResNet, DenseNet, and Vision Transformer.ResultsExperiments show the superior classification performance of our proposed network compared to state‐of‐the‐art methods. The overall accuracy is 0.9756. The values of sensitivity and specificity are very high as well. The confusion matrix provides information for the 6‐class classification task and demonstrates the superiority of our proposed network.ConclusionOur very deep Siamese network can provide accurate classification results of vocal cord leukoplakia, which facilitates early detection, clinical diagnosis, and surgical treatment. The excellent performance obtained in white light images can reduce the cost for patients, especially those living in developing countries.
Outcomes for 160 Consecutive Lateral Arm Free Flaps for Head and Neck Reconstruction
Authors: Contrera Kevin J. , Hassan Abbas M. , Shuck John W. , Bobian Michael , Ha Austin Y. , Chang Edward I. , Garvey Patrick B. , Roubaud Margaret S. , Lee Z‐Hye , Hanasono Mathew M. , Gross Neil D. , Myers Jeffrey N. , Yu Peirong , Largo Rene D. 
Published: December 2023

AbstractObjectiveExamine outcomes for lateral arm autologous tissue transfer in head and neck reconstruction.Study DesignRetrospective cohort study.SettingTertiary cancer center.MethodsAll patients who underwent traditional lateral arm, extended lateral arm, and lateral forearm flaps for head and neck reconstruction from 2012 to 2022 were assessed. Disabilities of the arm, shoulder, and hand (DASH) was measured. Factors associated with complications and enteral or mixed diet were evaluated by multivariable regression.ResultsAmong 160 patients followed for a median of 2.3 ± 2.1 years, defects were 54% oral tongue, 18% external, 9% maxilla, 8% buccal mucosa, 9% floor of mouth, and 3% pharynx. Flap types (and median pedicle lengths) were 41% traditional lateral arm (8 cm), 25% extended lateral arm (11.5 cm), and 34% lateral forearm (14 cm). All donor sites were closed primarily; 19.6% and 0% of patients had increased DASH scores 2 and 12 weeks after reconstruction. Major complications occurred in 18.1% of patients, including 6.3% reoperation, 6.9% readmission, 3.7% fistula, and 1.8% flap loss. Complications were independently associated with peripheral vascular disease (odds ratio [OR]: 5.71, 95% confidence interval [CI]: 1.5‐21.6, P = .01), pharyngeal defects (OR: 11.3, 95% CI: 1.4‐94.5, P = .025), and interposition vein grafts (OR: 3.78, 95% CI: 1.1‐13.3, P = .037).ConclusionThe lateral arm free flap was safe, versatile, and reliable for head and neck reconstruction with low donor‐site morbidity. Complications occurred in a fifth of patients and were associated with peripheral vascular disease, pharyngeal defects, and vein grafts.
Doxorubicin/poly(caprolactone)/polyethylene glycol nanoparticles prepared by electrospray
Authors: Mehrazin Mehdi , Asefnejad Azadeh , Naeimi Farid , Khonakdar Hossein Ali 
Published: December 2023

AbstractThe development of sustainable drug delivery systems is very important in the field of pharmaceutical research and has many advantages over the usual methods of drug administration, including improving effectiveness, reducing side effects, and increasing patient compliance. Among various techniques, electrospraying as a voltage‐driven process has emerged as a promising technology for the fabrication of drug‐loaded nanoparticles. In recent years, the application of electrospray approach for drug release has been widely investigated. However, optimization of electrospray process parameters and development of mathematical models to predict drug release kinetics from microparticles are still challenging. To address these issues, a combination of Central Composite Design (CCD) and Response Surface Methodology (RSM) has been used. This paper focuses on the application of CCD‐RSM for modeling and optimization of doxorubicin (DOX)‐poly(caprolactone) (PCL)‐polyethylene glycol (PEG) microparticles prepared using electrospray method. Doxorubicin, a widely used anticancer drug, exhibits potent cytotoxicity against a wide range of cancers. PCL‐PEG microparticles are promising as drug carriers due to their biocompatibility, controlled release properties, and ability to protect the encapsulated drug from degradation. The CCD‐RSM approach allows systematic investigation and optimization of several formulation and process variables, including polymer concentration, PCL‐PEG weight ratio, and applied voltage on drug release behavior. In addition, the effect of rheology and electrical conductivity of polymer fluid on the size of particles obtained from electrospraying was investigated. The effect of adding folic acid and doxorubicin in the optimized sample of nanoparticles and the effect of different concentrations of doxorubicin were investigated, and SEM, DLS, and FTIR techniques were used to characterize the microparticles, and the MMT test was performed to evaluate their cytotoxicity. The results showed that the optimized formulation is effective for sustained drug release over a long period for drug delivery applications.
Study on tensile strain of carbon fiber triaxial woven fabric/thermoplastic polyurethane flexible textile composites
Authors: Li Zhe , Li Wei 
Published: December 2023

AbstractIn order to study the possibility of flexible textile composites as space deployable devices, carbon fiber triaxial woven fabric and thermoplastic polyurethane were compounded by hot‐pressing. The section shape of the carbon fiber triaxial woven fabric flexible textile composites was observed by scanning electron microscopy. After hot‐pressing at 120°C for 45 min, the thermoplastic polyurethane is best combined with carbon fiber bundle, and fully melted to form a protective layer, which also ensured the deformability of carbon fiber triaxial woven fabric/thermoplastic polyurethane flexible textile composites. The tensile strains of flexible textile composites in the directions of 0°, 15° and 30° were analyzed by digital image correlation. The analysis was carried out from the macroscopic scale, the single cell scale, and the fiber bundle scale, combined with the strain distribution of digital image correlation in the tensile process. From the axial and radial deformation of the bundle and the force analysis of single cell, the phenomena such as strain change, trellising phenomenon, and fabric deformation during tensile were explained. When carbon fiber triaxial woven fabric is added to glass‐fiber composite, the electromagnetic reflection efficiency can be increased by 9%. The research on strain and electromagnetic reflection provided the possibility for the flexible textile composites as a space deployment device.Highlights
Through the use of SEM and hot‐pressing, carbon fiber triaxial woven fabric/TPU flexible textile composites with high coverage were produced.
The differences in strain distribution and deformation process throughout the CTFC tensile process at 0°, 15°, and 30° are investigated by DIC and stress analysis.
Carbon fiber triaxial woven fabric (TWF) can reflect electromagnetic radiation. TWF can increase the efficacy of reflection in composites. Space deployment is a possible application of TWF.
Effects of heat treatment on the dielectric and energy storage properties of BT‐PVDF nanocomposite films
Authors: Li Hongwei , Ye Lu , Zhang Yue , Ran Changning , Yan Tiantian , Liao Huimin , Zhang Jianjun , Ma Sude 
Published: December 2023

AbstractCeramic‐polymer nanocomposites exhibit good dielectric constant, low dielectric loss and excellent storage capacity for energy. A spin‐coating method was used to create 30 vol% BaTiO3 (BT) nanoparticles and polyvinylidene fluoride (PVDF) nanocomposite films with a homogeneous thickness of around 7 μm. The findings indicated that, with increasing the quenching temperature, the dielectric constant of the nanocomposite films decreased at 100 Hz. The dielectric constant of the BT‐PVDF nanocomposite film was 75.4 after quenched in air at 100°C, which was 21.4% greater than the that of the unquenched film. The breakdown strength of the films increased with increasing quenching temperature and reached the maximum values of 1400 kV/cm and 1600 kV/cm at 160°C, respectively. The breakdown strength of the film quenched in liquid nitrogen reached a maximum of 1600 kV/cm at 140°C. With increasing of quenching temperature, the charging density of BT‐PVDF nanocomposite film increased first and then decreases, reaching the maximum value of 11.165 J/cm3 at 140°C, which was 146% higher than that of the unquenched film. Heat treatment will be an innovative method for improving the dielectric and energy‐storage capabilities of ceramic‐polymer nanocomposite films.Highlights
The uniform thickness of the film prepared by spin‐coating was about 7 μm.
The dielectric properties of the composite film after quenching processes were improved.
The breakdown voltage and charging density were vastly enhanced after quenching processes.
Prediction of pseudo‐ductility and structural optimization of nacre‐inspired carbon fiber‐reinforced polymer laminate
Authors: Xiao Lin , Li Xiaodan , Han Runlin , Lu Chunrui , Wang Guanhui , Chen Lei , Zhang Dongxing 
Published: December 2023

AbstractTo enhance the ductility of carbon fiber‐reinforced polymer (CFRP) composites, a variety of nacre‐inspired structures with discontinuities were constructed based on the ratio of overlapping length to CFRP laminate thickness. The damage mechanisms and tensile characteristics of discontinuous laminates were elucidated using finite element analysis and experimental investigation. To anticipate the mechanical behavior of the CFRP laminate, an improved Chang‐Chang failure criteria was devised. Moreover, a model adopts the Benzeggagh‐Kenane criterion on cohesive surfaces for delamination initiation and propagation. The predicted stress–strain values are validated using experimental data under tensile stress. Furthermore, a mathematical model accurately predicted the relationship between the tensile performance of nacre‐inspired laminate and overlapping length. According to the findings, the longer the overlapping length (more than 19.5 mm) is, the lower the pseudo‐ductility. Meanwhile, the shorter the overlapping length (less than 17.5 mm) is, the lower the tensile strength. Furthermore, the laminate exhibits some pseudo‐ductility as well as little decrease in tensile strength when the overlapping length is approximately 18.5 mm.Highlights
A mathematical model for predicting the tensile properties of various nacre‐inspired laminates was established.
The relationship between the discontinuous structure and the pseudo‐ductility of the nacre‐inspired laminate was revealed. Compared with other similar structural laminates, the laminate with an overlapping length of 17.5 mm has better overall performance.
Proposed an improved Chang‐Chang progressive failure criterion that was utilized to simulate and analyze the mechanical response and damage of the nacre‐inspired laminates under tension.
Optical neurons to interconnect sensors and artificial brains in autonomous vehicles
Authors: Pérez‐Aranda Rubén , Pankert Joseph 
Published: December 2023

AbstractWith the ever‐increasing need for faster data communication in cars, electrical interconnects are beginning to show bandwidth and electromagnetic compatibility limitations. The new IEEE 802.3cz ethernet physical layer has been developed specifically to meet these needs, based on a long‐wavelength multimode VCSEL (vertical cavity surface‐emitting laser) and mature bend‐insensitive multimode fibers. A major innovation is taking place that will make automotive‐grade, multigigabit optical transceivers possible.
Venous thromboembolism management in people with cystic fibrosis
Authors: Abbinanti Alan , Witt Daniel M. , Saunders John , Jones Aubrey E. , Young David C. 
Published: December 2023

AbstractBackgroundRates of venous thromboembolism (VTE) are increasing in people with cystic fibrosis (PwCF). Providers treating VTE in PwCF have reported low confidence concerning anticoagulant drug selection, dose, duration, and drug–drug interactions. As there are currently no published reports regarding management of VTE in PwCF, our objective was to describe the management of VTE in PwCF.MethodsPwCF and VTE at the University of Utah Health were identified through electronic medical record searches. Patients were categorized into one of three treatment groups: warfarin, direct oral anticoagulant (DOAC), and low molecular weight heparin (LMWH). The primary outcome was episodes of major bleeding. Secondary outcomes included clinically relevant nonmajor (CRNM) bleeding.ResultsNine PwCF with a total of 12 unique VTE episodes were included in the study, with all but one episode associated with a peripherally inserted central catheter (PICC). Of the 12 VTE cases, 25% were treated with warfarin, 50% with a DOAC, and 25% with LMWH. There were no episodes of major bleeding and only one episode of CRNM bleeding (Hemoptysis) in the LMWH group. All anticoagulant doses and durations generally followed guidelines for persons without CF. DOACs were the most common VTE treatment, at doses and duration consistent with guidelines for persons without CF, with no major or CRNM bleeding.ConclusionVTE treatment in PwCF is generally consistent with guidelines for persons without CF with low rates of bleeding. DOACs are a potential option for treatment of VTE in PwCF, but more research is needed.
Lah Number Mediated Analytical Two‐center Two‐electron Integrals of Coulomb Green Function of H‐like Orbitals for 1Σ States
Authors: Kapil Bharti , Sharma Shivalika , Aggarwal Priyanka , Hazra Ram Kuntal 
Published: December 2023

AbstractEnergetics of two‐center two‐electron (2c–2e) systems carry challenges in theoretical understanding of Schrödinger equation (SE) for well‐known divergence of Coulomb interactions and nuclear separation (R) in modified H‐like AOs, Slater type orbitals (STOs), Gaussian type orbitals (GTOs), B‐spline, Sturmian function and etc. employed to VBT and MOT. Certain elegant computational and analytical techniques were developed for STO, GTO and other square integrable basis set within Born‐Oppenheimer (BO) approximation. STOs and GTOs have an essential limitation of absence of radial nodes. Thus, analytical treatment has become an urge for H‐like AOs. We have considered the diatomic molecules only for the sake of simplicity. Employing Sheffer identity in associated Laguerre polynomial/Whittaker‐M function forms of H‐like AOs and transforming integrals into elliptic coordinates with two nuclei on two foci furnishes exact, analytical and simple Coulomb integrals (Js) in terms of R. Lah number originated from
for nuclear coordinates only due to Sheffer identity shows that energetics of diatomic molecules can be anticipated as extremum function of R. Therefore, the optimization of potential energy surface (PES) of electrons as gradient of R may lead to σ‐bond formation. In this paper, we have developed diagonal Js for bound states of H2 molecule.
Finely Dispersed Fe3O4 and Ag Nanoparticles Adhered by Starch Nano‐layers: an Efficient Catalyst for the Synthesis of Pyrano[2,3‐d]Pyrimidines
Authors: Azad Poshtmakhi Sedigheh , Rad‐Moghadam Kurosh , Hosseinzadeh Hedyeh , Toorchi‐Roudsari Saeedeh 
Published: December 2023

AbstractHot‐water‐soluble starch (HWSS) was employed as binder for fabrication of a composite from magnetite and Ag nanoparticles (NPs). Electron microscopy images showed a good dispersion of magnetite NPs in the matrix of HWSS. This observation indicates that HWSS tends to coat the maximum surface of magnetite by encapsulation of individual magnetite NPs, leading to disassembly of their aggregates. The HWSS‐coated magnetite NPs were employed as nano‐support for immobilization of fine Ag NPs generated in situ via reduction of Ag+ cations by glucose. Monitoring of the formation and growth of Ag NPs by UV–Vis spectroscopy made it possible to set up an optimal condition for fabrication of the nano‐composite and to verify the supremacy of HWSS‐coated magnetite NPs over bare magnetite NPs as support in this new protocol. Valuable insights into the texture of the nano‐composite were obtained by VSM, FT‐IR and XRD studies. The bio‐derived nano‐composite displayed an interesting magnetic property and an efficient catalytic activity in the three‐component synthesis of pyrano[2,3‐d]pyrimidines. It is a robust heterogeneous catalyst and can be simply retrieved from reaction mixtures by magnetic separation method.
Exploring the Fluorescence Quenching of Sodium Dodecyl Sulfate Doped Polyaniline by Energetic Nitrocompounds
Authors: Ture Satish Ashok , Pattathil Shruthy D. , Yelamaggad Channabasaveshwar V. , Venkataraman Abbaraju 
Published: December 2023

AbstractThe fluorescence quenching studies using conducting polymers (CPs) have greatly contributed in the trace detection of high energy materials (HEMs) with nitro functional groups. Polyaniline doped with the anion surfactant sodium dodecyl sulfate (SDS) acts as a fluorophore and is used in fluorescence quenching studies to detect HEMs at trace levels. A mechanistic approach to understanding electron transfer during the interaction of fluorophore with HEMs were studied by using spectroscopic and electrochemical techniques. The presence of conjugation in conducting polymer shows a molecular wire effect during fluorescence quenching by trace level of HEMs by quenching several emissions in polymer chains. The Stern‐Volmer(S‐V) and limit of detection(LOD) plots give quenching mechanism and the efficiency of quenching. These values indicate that TNT had good sensitivity compared to other HEMs such as RDX, PETN, CL‐20 and CRCC. The FTIR and Raman studies were used to understand the interaction between nitro groups of HEMs with the benzenoid, polaronic and semi‐quinoid units of doped polyaniline. The cyclic voltammetry studies revealed shift in potential and current during the interaction of the fluorophore with HEMs, and these results were combined with fluorescence studies for better understanding of the possible mechanism of quenching.
Synthesis and Mechanism of p53‐MDM2 Inhibitors with Heterocyclic Structures: A Focused Review
Authors: Ji Li‐Tao , Zhang Wenjing , Zhang Yi , Zhao Su , Long Hai‐Tao , Qin Li‐Qing , Tian Jia‐Cheng , Li Hong‐Zhang , Zhu Dan‐Xue , Zhou Yan , Lu Yi‐Duo , Wang Zhen‐Chao , Li Cheng‐Peng 
Published: December 2023

AbstractP53 gene mutation is one of the important causes in tumors. p53‐MDM2 (murine double minute 2) inhibitors can interrupt p53‐dependent gene transcription activity, and inhibit p53‐mediated apoptosis, block p53‐MDM2/MDMx interaction, and significantly reduce DNA formation. In this article, we focused on the synthesis methods about nutlins and other p53 small molecule inhibitors, in order to find potential new structure for novel p53 small molecule inhibitor synthesizing.
Synthesis and Characterization of pH Triggered Imine Functional Low Molecular Weight Hydrogel
Authors: Deka Poonam , Chakraborty Amrita , Sarma Kashyap Kumar , Das Rituraj , Mahanta Sanjeev Pran , Althubeiti Khaled , Sarma Tridib Kumar , Thakuria Ranjit 
Published: December 2023

AbstractA C‐3 symmetric imine functional nonpolymeric low molecular weight gelator is prepared using microwave assisted Schiff base reaction. The synthesized molecule forms a hydrogel at 5 wt% under slightly acidic pH. The material was characterized using an inversion tube test, thermogravimetric analysis (TGA), powder X‐ray diffraction (PXRD) and FT‐IR spectroscopy. Rheological studies show the material forms a strong hydrogel with formation of nanofibrils supported by field‐emission scanning electron microscopy (FE‐SEM). To the best of our knowledge this is the first example of imine based trigonal low molecular weight hydrogelator reported.
Design and Synthesis of Oxazole‐Linked Pyrazole Chalcone Derivatives: In‐Vitro Anticancer Evaluation and In‐Silico Molecular Docking Studies
Authors: Rangaswamy Singamsetty , Sreenivasulu Reddymasu , Bhuvan Tej Mandava , Ramesh Babu Vankayala , Kumar Kapavarapu Ravi , Kumar Abbaraju V. D. N. 
Published: December 2023

AbstractA new series of oxazole linked pyrazole chalcone derivatives (9 a–j) has been developed, prepared and tested for in vitro anticancer activity against SiHa, A549, MCF‐7, and Colo‐205 cancer cell lines with etoposide employed as a positive control. The IC50 values of the synthesized compounds vary from 0.01±0.0081 μM to 11.6±6.10 μM, while the IC50 values of the positive control range from 0.14±0.017 μM to 3.11±0.11 μM, respectively. Six compounds such as 9 a, 9 b, 9 c, 9 d, 9 i, and 9 j have showed more potent activity than the others. Based on the docking simulations conducted on Human Topoisomerase II, it is evident that compounds 9 a, 9 b, 9 c, and 9 d exhibited superior binding affinity and interaction profiles compared to other compounds analyzed in this in silico study.
Structural Characterization, DFT Analysis and Catalysis by Highly Active Cationic Fe(II)‐Cu(I) Complexes in the Green Synthesis of Triazoles in Water
Authors: Neshat Abdollah , Kakavand Meysam , Cheraghi Mahdi , Balmohammadi Yaser 
Published: December 2023

AbstractTwo bimetallic Fe(II)‐Cu(I) complexes, with tetrahedral Cu(I) center stabilized in a S2P2 environment, were synthesized and fully characterized using single crystal X‐ray diffraction, multinuclear NMR, IR and UV‐Visible spectroscopy techniques. Density functional theory with PBE0‐D3(BJ) functional was employed to elucidate the electronic features of these novel metal complexes. The computational analysis revealed that while all Cu(I) complexes adopted a tetrahedral geometry in the gas phase with shorter P−Cu(I) bonds than the S−Cu(I) bonds. These cationic complexes were highly active in the catalytic cycloaddition reaction of azides onto terminal alkynes. The CuAAC reaction were carried out at room temperature with as low as 1 mg (0.1 mol %) of catalyst loading to deliver high yields of the corresponding 1,4 adducts of 1,2,3‐triazoles in water under aerobic conditions.
Ferrocenes and Porphyrins as Acidithiobacillus ferrooxidans Growth Activators under Ultrasound Irradiation
Authors: Rogatkina Elena Yu. , Mazina Svetlana E. , Rodionov Alexey N. , Simenel Alexander A. 
Published: December 2023

AbstractAcidithiobacillus ferrooxidans are beneficial bacteria for bioleaching in the mining industry to extract useful fractions from tons of waste. These bacteria are able to oxidize ferrous iron (Fe2+) to ferric iron (Fe3+) and use the released energy to assimilate carbon from carbon dioxide or carbonates, and can be used in the desulfurization of coal and gas. In this regard, activators of the growth of these bacteria may be useful. During the experiments on these bacterial strains, an unexpected effect of growth activation was revealed. This gives rise to further research in this direction and the identification of patterns of “structure‐activity” derivatives of ferrocene and porphyrins in relation to A. ferrooxidans.