bluuebunny/crossref_metadata_2025_split huggingface dataset:
Long‐term renal and hearing toxicity of carboplatin in infants treated for localized and unresectable neuroblastoma: Results of the SFOP NBL90 study
Authors: Bergeron C. , Dubourg L. , Chastagner P. , Mechinaud F. , Plouvier E. , Desfachelles A.S. , Dusol F. , Pautard B. , Edan C. , Plantaz D. , Froehlich P. , Rubie H. 
Published: March 2005

AbstractBackgroundA secondary end point of the NBL90 protocol (Rubie H et al. Pediatr Oncol 2001;36:247–250) was the concern in this infant population for possible carboplatin‐(CBDCA) induced late side effects including impaired renal and hearing functions.ProcedureGlomerular filtration rate (GFR), tubular function (TF), pure tone audiometry (PTA), high‐frequency, and transient evoked‐otoacoustic emission were prospectively assessed in 30 children alive and disease‐free 6 years after the end of the treatment.ResultsMedian age at diagnosis and at assessment was 4.7 months and 7 years, respectively. Blood pressure was ≤97.5 centile in all children. The mean estimated GFR was 114 ± 13 ml/min/1.73 m2 by Schwartz formula [range 87–145]. TF assessment failed to demonstrate any impairment. 29/30 children had grade 0 ototoxicity and all transient evoked otoacoustic emission were normal.ConclusionsWith a 6‐year follow‐up the combination of VP16 and carboplatin given at conventional doses is safe on renal and hearing functions in infants with unresectable neuroblastomas treated according to SFOP NB90. Pediatr Blood Cancer 2005; 45:32–36. © 2005 Wiley‐Liss, Inc.
Investigation of the microstructure of polypropylene prepared with ansa and fluxional metallocene catalysts with an extended Coleman–Fox model
Authors: Nele Márcio , Pinto José Carlos , Mohammed Muqtar , Collins Scott 
Published: March 2005

AbstractTemperature (T) effects on the microstructure of polypropylene made with metallocene catalysts have been investigated with the theoretical framework originally developed by Coleman and Fox and extended to the stereospecific polymerization of propylene with two‐state ansa and fluxional metallocene catalysts. T effects on the polymer microstructure are mainly due to factors other than changes in the intrinsic stereoselectivity of the two states. The model has been applied to the stereosequence distributions of polypropylene prepared with the C1‐symmetric Me2Si(Ind)(Flu)ZrCl2 complex, activated with methyl aluminoxane, over a range of T and monomer concentration ([M]) values. The use of these two variables, in combination with the Coleman–Fox model (or a kinetic model), allows more reliable estimates of fundamental parameters, especially when the microstructure is a weak function of one of these variables at a constant value of T (e.g., [M]). © 2005 Wiley Periodicals, Inc. J Polym Sci Part A: Polym Chem 43: 1797–1810, 2005
Synthesis of ethylene/propylene elastomers containing a terminal reactive group: The combination of metallocene catalysis and control chain transfer reaction
Authors: Kandil U. , Chung T. C. 
Published: March 2005

AbstractThis article discusses a chemical route to prepare new ethylene/propylene copolymers (EP) containing a terminal reactive group, such as ϕ‐CH3 and OH. The chemistry involves metallocene‐mediated ethylene/propylene copolymerization in the presence of a consecutive chain transfer agent—a mixture of hydrogen and styrene derivatives carrying a CH3 (p‐MS) or a silane‐protected OH (St‐OSi). The major challenge is to find suitable reaction conditions that can simultaneously carry out effective ethylene/propylene copolymerization and incorporation of the styrenic molecule (St‐f) at the polymer chain end, in other words, altering the St‐f incorporation mode from copolymerization to chain transfer. A systematic study was conducted to examine several metallocene catalyst systems and reaction conditions. Both [(C5Me4)SiMe2N(t‐Bu)]TiCl2 and rac‐Et(Ind)2ZrCl2, under certain H2 pressures, were found to be suitable catalyst systems to perform the combined task. A broad range of St‐f terminated EP copolymers (EP‐t‐p‐MS and EP‐t‐St‐OH), with various compositions and molecular weights, have been prepared with polymer molecular weight inversely proportional to the molar ratio of [St‐f]/[monomer]. © 2005 Wiley Periodicals, Inc. J Polym Sci Part A: Polym Chem 43: 1858–1872, 2005
Online wide‐angle X‐ray diffraction/small‐angle X‐ray scattering measurements for the CO2‐laser‐heated drawing of poly(ethylene terephthalate) fiber
Authors: Yamaguchi Takayoshi , Komoriyama Kohei , Ohkoshi Yutaka , Urakawa Hiroshi , Gotoh Yasuo , Terasawa Norihisa , Nagura Masanobu , Kajiwara Kanji 
Published: March 2005

AbstractFiber‐structure‐development in the poly(ethylene terephthalate) fiber drawing process was investigated with online measurements of wide‐angle and small‐angle X‐ray scattering with both a high‐luminance X‐ray source and a CO2‐laser‐heated drawing system. The intensity profile of the transmitted X‐ray confirmed the location of the neck‐drawing point. The diffraction images had a time resolution of several milliseconds, and this still left much room for improvement. Crystal diffraction appeared in the wide‐angle X‐ray images almost instantaneously about 20 ms after necking, whereas a four‐point small‐angle X‐ray scattering pattern appeared immediately after necking. With the elapse of time after necking, the four‐point scattering pattern changed into a meridional two‐point shape. © 2005 Wiley Periodicals, Inc. J Polym Sci Part B: Polym Phys 43: 1090–1099, 2005
Hydrogen‐bonding, crystallinity, and morphological properties of poly(silicic acid)/waterborne polyurethane nanocomposites
Authors: Ma Chen‐Chi M. , Su Hsun‐Yu , Kuan Hsu‐Chiang , Kuan Chen‐Feng , Chiang Chin‐Lung 
Published: March 2005

AbstractUnique nanocomposites consisting of poly(silicic acid) nanoparticles (PNs) and waterborne polyurethane (WPU) were prepared. The aliphatic WPU prepared in this study was end‐capped with a silanol group, which could react with PNs via a sol–gel process. PNs were modified with phenyltrimethoxysilane (PTMS) and 3‐(trimethoxysilyl)propyl ester (TMPE) and then blended with WPU. The structure–property relationships were examined. Solid‐state 29Si NMR spectra of WPU showed that structures T1, T2, and T3 of WPU decreased and structures Q3 and Q4 of PN/WPU nanocomposites increased gradually. When the PN concentration increased to 10 wt %, PN/WPU nanocomposites exhibited the maximum fraction of hydrogen‐bonded carbonyl groups. In the PTMS–PN and TMPE–PN systems, the fraction of hydrogen‐bonded carbonyl groups fluctuated stably when the concentrations of PTMS–PN and TMPS–PN exceeded 5 wt %. The X‐ray diffraction results revealed that α‐form, γ‐form, or triclinic crystallization could be found in the WPU matrix. A differential scanning calorimetry spectrum showed that the crystalline structure of the hard segment of WPU was influenced by the nanoparticle concentration. The degrees of crystallinity were 88% for the PN/WPU nanocomposites, 41% for the PTMS–PN/WPU nanocomposites, and 54% for the TMPE–PN/WPU nanocomposites when the PN, PTMS–PN, and TMPE–PN concentrations were 5 wt %. © 2005 Wiley Periodicals, Inc. J Polym Sci Part B: Polym Phys 43: 1076–1089, 2005
Icing processes associated with high Arctic perennial springs, Axel Heiberg Island, Nunavut, Canada
Authors: Pollard Wayne H. 
Published: March 2005

AbstractSaline perennial springs have been documented at six locations on Axel Heiberg Island in the Canadian high Arctic. Spring discharge rates, temperatures and chemistry, and associated icing and frost mound formation have been documented at two locations in the Expedition Fiord area since 1988 and at one location near Whitsunday Bay since 1996. Cold Ca‐ and Na‐rich waters discharge near the base of Gypsum Hill and Colour Peak at Expedition Fiord. A large oval‐shaped icing up to 2 m thick forms at the base of Gypsum Hill while at Colour Peak the springs have formed a series of gullies and travertine deposits which develop three small icing and frost mounds systems in winter. At Whitsunday Bay cold discharge is from a single outlet and is confined by a deep channel where it forms a salt tufa. Where the channel emerges onto the floodplain a large fan‐shaped icing is formed. This paper also documents spring discharge and icing activity from three other non‐glacial sources and one glacial source. The icings and frost mounds formed by these springs are very different from those formed by late summer and early winter subglacial discharge. The high solute concentrations lead to freezing‐point depression, complex patterns of freezing and the formation of brine icings, together with a variety of mineral precipitates. Freezing‐point depression experiments help explain icing hydrology and the spatial pattern of icing formation. Copyright © 2005 John Wiley & Sons, Ltd.
Automated use of mutagenesis data in structure prediction
Authors: Nanda Vikas , DeGrado William F. 
Published: March 2005

AbstractIn the absence of experimental structural determination, numerous methods are available to indirectly predict or probe the structure of a target molecule. Genetic modification of a protein sequence is a powerful tool for identifying key residues involved in binding reactions or protein stability. Mutagenesis data is usually incorporated into the modeling process either through manual inspection of model compatibility with empirical data, or through the generation of geometric constraints linking sensitive residues to a binding interface. We present an approach derived from statistical studies of lattice models for introducing mutation information directly into the fitness score. The approach takes into account the phenotype of mutation (neutral or disruptive) and calculates the energy for a given structure over an ensemble of sequences. The structure prediction procedure searches for the optimal conformation where neutral sequences either have no impact or improve stability and disruptive sequences reduce stability relative to wild type. We examine three types of sequence ensembles: information from saturation mutagenesis, scanning mutagenesis, and homologous proteins. Incorporating multiple sequences into a statistical ensemble serves to energetically separate the native state and misfolded structures. As a result, the prediction of structure with a poor force field is sufficiently enhanced by mutational information to improve accuracy. Furthermore, by separating misfolded conformations from the target score, the ensemble energy serves to speed up conformational search algorithms such as Monte Carlo‐based methods. Proteins 2005. © 2005 Wiley‐Liss, Inc.
Mammotome: Less Invasive than ABBI with Similar Accuracy for Early Breast Cancer Detection
Authors: Weber Walter P. , Zanetti Rosanna , Langer Igor , Dellas Sophie , Zuber Markus , Moch Holger , Remmel Eugenia , Oertli Daniel , Wight Edward , Marti Walter R. 
Published: March 2005

AbstractWe performed a prospective analysis of two consecutive biopsy cohorts investigated by the same team to compare the Mammotome system with the ABBI procedure. From April 1997 to August 2003 a series of 413 nonpalpable mammographic lesions in 387 women (median age 56 years, range 30–84 years) were stereotactically biopsied in the University Hospital of Basel, Switzerland. Until October 1999 the ABBI system was applied exclusively, it was subsequently superseded by the Mammotome device in our clinic. Main outcome measures were accuracy, technical demand, and morbidity. Sensitivity (97.3%/96.8%), negative predictive value (99.2%/98.7%), and diagnostic accuracy (99.4%/99.1%) regarding the detection of malignancy were excellent for both techniques (ABBI/Mammotome). The Mammotome procedure was faster and less invasive, thus causing significantly less morbidity. The larger specimen obtained by the ABBI procedure resulted in more detailed histology. In conclusion, recommend the Mammotome system as the method of choice for detecting nonpalpable early breast cancer.
Electronic textbooks that transform how textbooks are used
Authors: McFall Ryan 
Published: March 2005

PurposeThis paper's goals are to motivate the design of an electronic textbook that seeks to transform how textbooks are used inside and outside the classroom. In particular, it seeks to show that merely creating an electronic form of an existing paper textbook is not a sufficiently motivating condition for instructors and students to move from paper to electronic textbooks, and doing so misses much of the opportunities presented by electronic media to enhance learning from textbooks.Design/methodology/approachAn electronic textbook application running on Microsoft's TabletPC operating system was implemented and used as the primary text in three offerings of an Introductory Computer Science course, with one section used as a control group. Student learning was assessed via course examinations and overall grades, and student perceptions and use of the textbook were assessed via surveys.FindingsNo significant differences in student learning or textbook usage were observed between students using the electronic and paper versions of the textbook. The surveys indicated a generally neutral reaction to the electronic textbook.Research limitations/implicationsThe number of students used to evaluate the electronic textbook's effectiveness was small, and the text was not evaluated in multiple types of courses.Practical implicationsInstructors often teach and assess students in such a way that reading the text is not required for success. If instructors continue to assign textbooks, a way must be found to motivate their use and improve the way students use them.Originality/valueThis paper gives guidance to those seeking to design and implement electronic books in an educational setting.
Electronic books: their integration into library and information centers
Authors: Subba Rao Siriginidi 
Published: March 2005

PurposeTo highlight the salient features of e‐books, challenges that arise in integrating e‐books into library and information centers (LICs), e‐books business models and licensing, and future of e‐books.Design/methodology/approachDiscusses the emergence of e‐books and a comprehensive definition for them. Lists various implementations of e‐books, their advantages and disadvantages in LICs and compares select e‐book reader hardware and software with their specifications, requirements and characteristics.FindingsExamines several issues to integrate e‐books into LICs to find workable solutions based on identification, selection, circulation, maintenance, quality assurance, pricing, fair use, standards and interoperability, business models and licensing.Research limitations/implicationsE‐books are a new convergence of various traditional works and functions based on the application of new information technology.Practical implicationsThe issues causing concerns to users and LICs can be sought by collaborating with industry to ensure LICs play a continuous role in communication information and act as repositories of knowledge, for the benefit of society.Originality/valueThis paper offers practical solutions for LICs in integrating e‐books in their collection.
Advertising appeals and cultural values in television commercialsA comparison of Hong Kong and Korea
Authors: Sook Moon Young , Chan Kara 
Published: March 2005

PurposeThe objective of this study is to investigate to what extent advertising appeals in Hong Kong and Korea are different, and whether the differences between the two countries can be attributed to the differences in nations' cultural characteristics. Hypotheses are drawn in relation to the two dimensions of Hofstede's framework – uncertainty avoidance and masculinity/femininity.Design/methodology/approachA sample of 803 prime‐time television commercials from the two countries was analyzed using Cheng and Schweitzer's classification of advertising appeals.FindingsThe results show that femininity is an important variable for explaining differences in advertising between Hong Kong and Korea. Both Hong Kong and Korean advertising show no difference in values of high uncertainty avoidance, although an appeal of high uncertainty avoidance was used more often in Korean advertising. However, values of low uncertainty avoidance are more prevalent in television commercials in Korea, a country of high uncertainty avoidance, than Hong Kong, a country of low uncertainty avoidance. It is also found that the correlation between product categories and cultural values is society‐based.Originality/valueThis study reveals that Hofstede's framework does explain cross‐cultural differences between Hong Kong and Korea and provides empirical evidences for the impact of value paradoxes on advertising in both countries, suggesting that Hofstede's framework and the value paradoxes provide a possible theory for testing the relationship of the society and its advertising content within a culture as well as across cultures.
The influence of country image structure on consumer evaluations of foreign products
Authors: Laroche Michel , Papadopoulos Nicolas , Heslop Louise A. , Mourali Mehdi 
Published: March 2005

PurposeThis study was designed to extend knowledge of cognitive processing of country of origin cues by refining the concept of country image and investigating its role in product evaluations.Design/methodology/approachData were collected from residents of a large North American metropolitan. A total of 436 usable questionnaires were returned. Data analysis was conducted using the EQS structural equation modeling softwareFindingsWe found that country image is a three‐dimensional concept consisting of cognitive, affective, and conative components. We modeled the relationships among country image, product beliefs, and product evaluations, and found that country image and product beliefs affect product evaluations simultaneously regardless of consumers' level of familiarity with a country's products. Findings also indicated that the structure of country image influences product evaluations both directly and indirectly through product beliefs. Consistent with affect transfer theory, the results showed that when a country's image has a strong affective component, its direct influence on product evaluations is stronger than its influence on product beliefs. Alternatively, when a country's image has a strong cognitive component, its direct influence on product evaluations was smaller than its influence on product beliefs.Research limitations/implicationsOne limitation pertains to the relatively poor psychometric properties of some items. Future research will benefit from further improvements in the measures of country image that tap into the various facets of the construct.Originality/valueThe major contributions of the study consist of the full operationalization of country image as a three‐dimensional concept, and the findings on the impact of country image structure on consumers' evaluation processes.
“If at first you don't succeed … ”: web site redesign at the UNLV Libraries
Authors: Felker Kyle , Kim Chung Su 
Published: March 2005

PurposeTo document a library web site redesign from start to finish, with special attention and emphasis placed on process – what worked and what did not.Design/methodology/approachDocumentation and techniques used in the redesign are discussed in depth, with special attention as to why these techniques were chosen, how they were integrated into the process, and what problems were encountered.FindingsOne of the biggest problems with a redesign is the political dimension and communication issues involved, rather than the technical problems. Deciding what testing methodology to use to gather patron input and using that input efficiently in the site design are also a challenging area.Research limitations/implicationsSince this is a case study, some of the problems encountered may not be applicable to other libraries in different environments. At the same time, many of the findings relating to problems with communication are general and could apply to redesign efforts in a variety of environments.Practical implicationsIt is hoped that this paper may serve as a foundation on which a more generic process for effecting a redesign can be developed, one that may apply to all or most redesigns in all or most libraries.Originality/valueThere are very few papers in the literature dealing with the process of managing a redesign – most focus on other aspects, such as skill sets or test findings.
Managing patients with identical names in the same ward
Authors: Lee Anselm C.W. , Leung Mona , So K.T. 
Published: March 2005

PurposeTo review the experience of managing two patients with identical names in the same ward during a five‐month period.Design/methodology/approachThe records of the patients were reviewed to look for incorrect entries, errors in specimens sampling, administration of blood products and chemotherapy, and misplacement of clinical notes. Doctors and nurses involved were also invited to complete a questionnaire study to comment on the usefulness of the measures implemented for correct patient identification. A random sample of 60 patients was also selected to see if their full names were shared with other patients attending the same hospital.FindingsAmong the 1,442 sheets of hospital records from the two patients, no errors pertaining to the clinical activities were found. However, 13 (0.9 per cent) sheets of the hospital records were misplaced. The 21 doctors and nurses participating in the questionnaire study gave positive support to all the additional measures implemented for safeguarding patient identification, of which the automated alerting feature in the electronic clinical management system received the highest scores. A total of 32 (53 per cent) of the 60 sampled patients shared a common full name with one to 101 other patients attending the same hospital.Originality/valuePatients with identical names staying in the same ward present a unique challenge to acute health‐care settings. The situation is especially relevant in communities where most people's names are not unique. Specific guidelines and measures are needed to prevent patient misidentification. Errors in filing of patient notes and laboratory reports to the hospital record deserve further attention.
Discourses of disrupted identities in the practice of strategic change
Authors: Beech Nic , Johnson Phyl 
Published: March 2005

PurposeTo explore identity dynamics in the lived experience of a strategic change over time.Design/methodology/approachQualitative data were collected through a longitudinal engagement with the focal organisation. Narrative analysis was used to trace the identity dynamics of senior figures in an organisation as it went through strategic change. This entailed a change of CEO and chairman, alterations to the composition of the board and the executive team and, in association with these changes in personnel, alterations to the strategy and direction of the company.FindingsThe identity dynamics were at times comfortable and uncomfortable fits for the individuals involved, and over time expectations and realisations impacted on the processes of change in ways that were unexpected and unintentional for the actors. The outcome of the analysis shows the disruptive impact of identity dynamics on the practice of strategic change.Research limitationsThe nature of the research undertaken does not seek to represent a holistic case study but, rather, is focused on a depth analysis of selected interactional data.Practical implicationsA critique of traditional views of resistance to change is presented and an alternative approach to analysing reactions to change is proposed.Originality/valueThe paper contributes a narrative approach to the discursive analysis of strategic change. It also elaborates the significance of “identity work” in such settings.