bluuebunny/crossref_metadata_2025_split huggingface dataset:
Auricular vagus nerve stimulation for mitigation of inflammation and vasospasm in subarachnoid hemorrhage: a single-institution randomized controlled trial
Authors: Huguenard Anna L. , Tan Gansheng , Rivet Dennis J. , Gao Feng , Johnson Gabrielle W. , Adamek Markus , Coxon Andrew T. , Kummer Terrance T. , Osbun Joshua W. , Vellimana Ananth K. , Limbrick David D. , Zipfel Gregory J. , Brunner Peter , Leuthardt Eric C. 
Published: January 2025

OBJECTIVE
Inflammation contributes to morbidity following subarachnoid hemorrhage (SAH). The authors of this study evaluate how applying noninvasive transauricular vagus nerve stimulation (taVNS) can target this deleterious inflammatory response following SAH and reduce the rate of radiographic vasospasm.

METHODS
In this prospective, triple-blinded, randomized controlled trial, 27 patients were randomized to taVNS or sham stimulation. Serial blood and CSF samples were collected every 3 days to quantify inflammatory markers. Radiographic cerebral vasospasm severity and functional outcomes (modified Rankin Scale scores) were analyzed.

RESULTS
No adverse events occurred. Radiographic vasospasm was significantly reduced (p = 0.018), with serial vessel caliber measurements demonstrating a more rapid return to normal than in the sham-treated group (p < 0.001). In the taVNS group, tumor necrosis factor–α was significantly reduced in both plasma (days 7 and 10) and CSF (day 13); interleukin-6 was also significantly reduced in plasma (day 4) and CSF (day 13) (p < 0.05). Patients receiving taVNS had higher rates of favorable outcomes at discharge (38.4% vs 21.4%) and first follow-up (76.9% vs 57.1%). Patients treated with taVNS had significant improvement in modified Rankin Scale scores from admission to first follow-up (p = 0.014), unlike patients in the sham-treated group (p = 0.18). The taVNS group had a significantly lower rate of discharge to a skilled nursing facility or hospice (p = 0.04).

CONCLUSIONS
taVNS is a noninvasive method of neuro- and systemic immunomodulation. This trial supports the finding that taVNS following SAH can mitigate the inflammatory response, reduce radiographic vasospasm, and potentially improve functional and neurological outcomes.
Neuroendoscopic lavage for posthemorrhagic hydrocephalus of prematurity: preliminary results at a single institution in the United States
Authors: Flanders Tracy M. , Hwang Misun , Julian Nickolas W. , Sarris Christina E. , Flibotte John J. , DeMauro Sara B. , Munson David A. , Heimall Lauren M. , Collins Yong C. , Bamberski Jena M. , Sturak Meghan A. , Storm Phillip B. , Lang Shih-Shan , Heuer Gregory G. 
Published: January 2025

OBJECTIVE
The current neurosurgical treatment for intraventricular hemorrhage (IVH) of prematurity resulting in posthemorrhagic hydrocephalus (PHH) seeks to reduce intracranial pressure with temporary and then permanent CSF diversion. In contrast, neuroendoscopic lavage (NEL) directly addresses the intraventricular blood that is hypothesized to damage the ependyma and parenchyma, leading to ventricular dilation and hydrocephalus. The authors sought to determine the feasibility of NEL in PHH.

METHODS
The records of patients with a diagnosis of grade III or IV IVH were reviewed between September 2022 and February 2024. The Papile grade was determined on cranial ultrasonography. Demographic information collected included gestational age, birth weight, weight at the time of surgical intervention, infection confirmed with CSF, and rehemorrhage. Standard local guidelines for temporary (CSF reservoir) and permanent (shunt or endoscopic third ventriculostomy [ETV]) CSF diversion were implemented. Warmed lactated Ringer’s was utilized for NEL. The primary outcome was the need for permanent CSF diversion (shunt or ETV).

RESULTS
Twenty consecutive patients with grade III or IV IVH complicated by PHH were identified. Twelve patients underwent CSF reservoir placement and NEL, 4 underwent CSF reservoir placement only, 1 underwent shunt placement only, and 3 did not require neurosurgical intervention. Of the 12 patients who underwent reservoir placement and NEL, 8 (67%) ultimately met criteria for permanent CSF diversion compared with 2 of 4 (50%) who underwent CSF reservoir placement only. The mean gestational age at birth, birth weights, and age/weight at time of temporary CSF diversion were similar across groups. The average time interval between temporary and permanent CSF diversion was longer in patients who underwent NEL (2.5 months for shunt and 6.5 months for ETV) compared with CSF reservoir placement only (1.1 months).

CONCLUSIONS
NEL is an innovative alternative for the treatment of PHH of prematurity. The authors established an endoscopic lavage program at their institution and herein report the first published account in the United States of the feasibility of NEL for PHH.
The utility of routine intraoperative CSF during ventricular shunt insertion: a 10-year retrospective cohort study
Authors: Stuart Michael J. , Harbison Annabelle M. , Ruder Timothy , Hackney Joshua , Jardim Amelia J. , Ma Norman , Campbell Robert A. J. , Coulthard Liam G. 
Published: January 2025

OBJECTIVE
Ventricular shunt insertion is a common procedure in pediatric neurosurgical practice. In many areas of medicine there is a push toward rationalization of healthcare resources and a reduction in low-value tests or procedures. The intraoperative sampling of CSF at the time of shunt insertion is one traditional aspect of care that has not been rigorously evaluated. Additionally, the role of CSF cell counts and chemistry in predicting shunt dysfunction is often discussed but poorly studied. A recent meta-analysis found a correlation between elevated CSF protein levels and shunt failure in patients with tuberculous meningitis, but not other pathologies, which limits the generalizability of those findings to Western populations. The aims of this study were to assess the clinical utility of intraoperative CSF sampling during insertion of ventricular shunts and to describe any association of routine intraoperative CSF sample parameters with shunt failure or infection.

METHODS
A retrospective review of a prospectively maintained surgical database covering 10 years of consecutive cases from a quaternary Australian pediatric neurosurgical center serving a population of 5.3 million was conducted. Statewide electronic medical records were reviewed to collate data on demographics, postoperative imaging, CSF biochemistry, instances of shunt failure, shunt revisions, and mortality. Patients undergoing insertion of a new ventricular shunt were included, while all cases of shunt revision were excluded.

RESULTS
During the study period, 1485 shunt procedures were performed, of which 427 involved the placement of a new ventriculoperitoneal shunt system. The mean patient age was 5.2 years (range premature–18 years). Of the 427 cases, 377 (88%) underwent routine CSF sampling. The most common indications for shunt revision were proximal catheter obstruction (51/173, 29%), followed by infection (29/173, 17%) and valve blockage (23/173, 13%). During the study period, 3 patients with existing intracranial hardware had overt ventriculitis identified at the time of intraoperative sampling, resulting in shunt removal. One patient with an existing ventricular reservoir had a delayed clinically significant infection identified on intraoperative cultures. Elevated CSF protein levels were associated with shunt failure during follow-up (area under the curve 0.625). The identified cutoff of 300 mg/L was significantly associated with a reduced time to shunt failure in both univariate and multivariate analyses.

CONCLUSIONS
It may be reasonable to consider omission of routine intraoperative CSF sampling at the time of shunt insertion in patients without existing intracranial hardware. Elevated CSF protein levels are associated with a reduced time to shunt failure in a dose-dependent manner.
Impact of disease duration and surgical intervention on arousal networks in temporal lobe epilepsy
Authors: Doss Derek J. , Gummadavelli Abhijeet , Johnson Graham W. , Makhoul Ghassan S. , Shless Jared S. , Bibro Camden E. , Jacobs Monica L. , Kang Hakmook , Haas Kevin F. , Bick Sarah K. , Terry Douglas P. , Dawant Benoit M. , Chang Catie , Morgan Victoria L. , Englot Dario J. 
Published: January 2025

OBJECTIVE
Epilepsy is a common neurological disease affecting nearly 1% of the global population, and temporal lobe epilepsy (TLE) is the most common type. Patients experience recurrent seizures and chronic cognitive deficits that can impact their quality of life, ability to work, and independence. These cognitive deficits often extend beyond the temporal lobe and are not well understood. It has been proposed in the extended network inhibition hypothesis that repeated spread of seizure activity to the ascending reticular activating system (ARAS) may contribute to these deficits. Disease duration has been associated with other network changes in patients with TLE, but few studies have investigated the relationship between disease duration, ARAS connectivity, and cognitive deficits in TLE. Furthermore, epilepsy surgery can result in seizure freedom and cognitive improvement in some patients, but it is unclear how the surgery affects ARAS connectivity.

METHODS
Resting-state functional MRI data were collected for patients with TLE (preoperatively in 40 and postoperatively in 25), and for 40 age-matched healthy controls. Functional connectivity was computed between all regions. Functional connectivity and segregation, a graph-theory measure of network isolation, were compared across the age spectrum in patients and controls. These same measures were evaluated as a function of epilepsy duration by controlling for age using a linear model built on healthy control data.

RESULTS
The authors found that increases in epilepsy duration were associated with greater segregation of the ARAS and decreased functional connectivity between the pedunculopontine tegmental nucleus and the frontoparietal association cortex. Furthermore, patients with impaired neurocognitive function were noted to have longer epilepsy duration and higher ARAS segregation compared to patients with spared neurocognition. After surgery, completely seizure-free patients demonstrated ARAS connectivity patterns that resembled those found in controls, whereas patients with residual seizures had persistent abnormal connectivity.

CONCLUSIONS
These findings suggest that recurrent seizures may contribute to isolation of critical subcortical activating structures, possibly impacting cognitive function. Furthermore, some ARAS functional connectivity abnormalities can be reversed if seizure freedom is achieved after epilepsy surgery. These results provide support for the extended network inhibition hypothesis, may lend insight into the progressive effect of recurrent seizures on arousal networks, and may lead to improved interventions to halt or reverse network impairments in patients with TLE.
Competing pathways of intracranial aneurysm growth: linking regional growth distribution and hemodynamics
Authors: Karnam Yogesh , Mut Fernando , Robertson Anne M. , Kaneko Naoki , Cebral Juan R. 
Published: January 2025

OBJECTIVE
The complex mix of factors, including hemodynamic forces and wall remodeling mechanisms, that drive intracranial aneurysm growth is unclear. This study focuses on the specific regions within aneurysm walls where growth occurs and their relationship to the prevalent hemodynamic conditions to reveal critical mechanisms leading to enlargement.

METHODS
The authors examined hemodynamic models of 67 longitudinally followed aneurysms, identifying 88 growth regions. These regions (of enlargement) were pinpointed through alignment and distance mapping between baseline and follow-up models. Aneurysm wall subdivisions were created based on saccular anatomy and flow-related characteristics, which were used to assess local hemodynamics. The distribution of growing regions across these subdivisions was then studied and stratified by aneurysm location and morphology to reveal distinct growth patterns. Statistical significance was evaluated using the Kruskal-Wallis and Mann-Whitney tests.

RESULTS
Growth predominantly occurred in the body (p < 0.0001) of aneurysms, with anterior communicating artery (ACom) (p < 0.0001) and lateral (p = 0.002) aneurysms showing a significantly greater tendency for growth in this region. In comparison, middle cerebral artery (MCA) (p < 0.0001) and bifurcation (p = 0.0001) aneurysms demonstrated growth in both the dome and the body. Notable differences in growth distribution across saccular regions included ACom versus MCA (neck, p = 0.038), bifurcation versus lateral (neck, p = 0.008), and so forth. The central flow region saw the most growth (p < 0.0001); although not significant, ACom (p = 0.196) and lateral (p = 0.218) aneurysms showed a tendency for growth in inflow and central zones, while MCA (p = 0.001) and bifurcation (p < 0.0001) aneurysms were more likely to grow in the central flow region.

CONCLUSIONS
Two primary mechanisms seem to influence aneurysm growth: high-flow impingement jets in the neck, body, and inflow zones leading to wall degeneration/thinning, mainly in ACom aneurysms; and slow, oscillatory flow conditions in the dome and central flow zones promoting wall remodeling/thickening, mainly in MCA aneurysms. This latter mechanism is also observed as secondary flows in ACom aneurysms. These findings emphasize the need to understand the distinct and sometimes concurrent mechanisms of aneurysm growth, advocating for targeted monitoring and interventions that mitigate rupture risks by considering the unique hemodynamic environments within different aneurysm regions and locations.
Efficacy comparison and outcome predictors of GPi- and STN-targeted deep brain stimulation for Meige syndrome: a systematic review of individual patient data
Authors: Xie Hutao , Huang Jiansong , Diao Yu , Yin Zixiao , Wang Shu , Zhang Quan , Shan Ming , Fan Houyou , Zheng Zhaoting , Zhao Zehua , Zhu Guanyu , Jiang Yin , Zhang Jianguo 
Published: January 2025

OBJECTIVE
The aim of this study was to evaluate outcomes of deep brain stimulation (DBS) for Meige syndrome, compare the efficacy of globus pallidus internus (GPi) and subthalamic nucleus (STN) as targets, and identify potential outcome predictors.

METHODS
The PubMed, Embase, and Web of Science databases were systematically searched to collect individual data from patients with Meige syndrome receiving DBS. Outcomes were assessed using the Burke-Fahn-Marsden Dystonia Rating Scale motor (BFMDRS-M) and disability (BFMDRS-D) scores. Data were analyzed using pooled meta-analysis. The study is registered in the PROSPERO database.

RESULTS
The analysis included 233 patients from 26 studies, with significant publication bias (p = 0.008, Egger’s test), but showed significant improvements in BFMDRS-M (65.09% ± 26.65%) and BFMDRS-D (53.48% ± 42.44%) scores at the final follow-up (mean duration 27.10 ± 33.64 months). No significant differences were observed in BFMDRS-M score improvement (mean difference −2.58%, 95% CI −15.84% to 10.69%; p = 0.430) or risk difference for response (−0.97%, 95% CI −10.08% to 8.15%; p = 0.835) between the GPi and STN target groups at the final follow-up across all follow-up periods (0 to ≤ 6, > 6 to ≤ 12, > 12 to ≤ 24, > 24 to ≤ 36, and > 36 months). Multiple regression analysis revealed a negative correlation between disease duration and treatment efficacy and a positive correlation between preoperative BFMDRS score and treatment outcome.

CONCLUSIONS
DBS significantly improves motor symptoms and disability in patients with Meige syndrome, with GPi and STN targets providing comparable efficacy. The efficacy of DBS diminishes with longer disease duration, underscoring the importance of early intervention.
Posterior extent of left anterior temporal lobectomy and picture naming decline
Authors: Mezjan Insafe , Colnat-Coulbois Sophie , Aron Olivier , Ferrand Mickaël , Brissart Hélène , Forthoffer Natacha , Maillard Louis , Rech Fabien 
Published: January 2025

OBJECTIVE
Recent voxel-based lesion symptom mapping (VLSM) studies have identified a critical region for picture naming, located 3.4 to 6.1 cm from the temporal pole. Its resection during left temporal lobe epilepsy surgery led to postoperative decline in picture naming. However, postoperative anomia has been reported after classic left temporal lobectomy, which rarely extends so posteriorly. The aim of the present study was to evaluate patients’ postoperative picture naming outcome on the basis of their precise surgical cavities in light of the recent findings from VLSM studies.

METHODS
In this monocentric retrospective study, the authors analyzed picture naming outcome and the surgical cavities of 34 patients who underwent surgery for left temporal lobe epilepsy. The authors evaluated their cohort’s surgical cavities on the basis of the critical regions identified by VLSM studies as essential to picture naming.

RESULTS
The surgical cavities of patients were anterior to the critical regions for picture naming identified by VLSM studies in the literature. Eight of 11 patients with postoperative lexical access decline at 18 months had a posterior limit of the lesioned voxels that did not reach the critical region identified by VLSM studies. Only 3 of 11 patients with a postoperative picture naming decline had surgical cavities reaching these critical regions. Conversely, 3 of 23 patients with stable or improved postoperative picture naming had surgical cavities reaching these critical regions.

CONCLUSIONS
Keeping a surgical cavity anterior to the limits identified by recent VLSM studies does not protect patients from postoperative picture naming decline. Interindividual anteroposterior variability of the basal temporal language area could complete the explanation offered by VLSM.
Entrepreneurship Learning by Making Tire Polish as a Practical Business Skill for Mothers in RT 04 RW 15 Tuah Madani Subdistrict
Authors: Zulfahri*  , Monice  , Halilintar Masnur P. , Darmansyah  
Published: January 2025

Industri semir ban mengalami kemajuan pesat, inovasi terkini mencakup penggunaan nanoteknologi untuk meningkatkan daya tahan dan performa, serta pengembangan bahan ramah lingkungan guna mengurangi dampak negatif terhadap lingkungan. Sebagai ibu, peran kita tidak hanya sebagai pendukung keluarga tetapi juga sebagai potensi wirausaha yang luar biasa. Terlibat dalam dunia kewirausahaan, khususnya dalam pembuatan semir ban, tidak hanya memberikan peluang finansial, tetapi juga memungkinkan kita meraih kemandirian dan meningkatkan keterampilan bisnis praktis. Pembelajaran Kewirausahaan dengan Pembuatan Semir Ban sebagai Keterampilan Bisnis Praktis bagi Ibu-Ibu didesain khusus untuk memberikan panduan langkah demi langkah dalam memahami, merencanakan, dan menjalankan usaha pembuatan semir ban yang praktis. Berdasarkan hasil pembahasan diperoleh mitra pembuatan semir ban setelah penyuluhan Pengetahuan tentang Definisi Bahan Kimia 100%, Pengetahuan tentang Definisi Semir Ban 94,7%, Pengetahuan tentang Manfaat Semir Ban: 100%, Pengetahuan tentang Bahan Utama Pembuatan Semir Ban 100%, Pengetahuan tentang Proses Pembuatan Semir Ban 94,7%, Pengetahuan tentang Keamanan Selama Pembuatan Semir Ban 94,7% dan Kepuasan terhadap Pelaksanaan Acara setelah Pelatihan sebesar 100%.
Yuri Knórosov y su trabajo en las islas Kuriles (Rusia)
Authors: Khokhriakova Sandra Viskanta , Sekacheva Daria 
Published: January 2025

El artículo presenta los resultados del trabajo de Yuri Valentinovich Knórosov en las islas Kuriles y también las cartas individuales de Knórosov del fondo 40 del archivo de la MAE (Kunstkamera) RAS sobre sus expediciones a las islas Kuriles. Knórosov es ampliamente conocido principalmente por su trabajo de desciframiento de la escritura maya, pero sus intereses científicos también abarcaron las islas Kuriles. Yuri Valentinovich realizó nueve expediciones a las islas Kuriles y dejó una contribución significativa al estudio de la población local los ainus. Los materiales del Fondo 40 muestran que el trabajo de Knórosov no se limitó solo a la investigación científica; la correspondencia informal citada en el artículo demuestra que el científico vio la importancia del trabajo educativo con los residentes locales.
JOB SATISFACTION SCALE FOR TECH WORKERS: IMPLEMENTATION COMPASS
Authors: Ehigbochie Amenawon Imuwahen , Ekuobase Godspower Osaretin 
Published: January 2025

Tech workers are not just employees but ubiquitous architects and drivers of the imminent digitalized future. Tech worker’s wellbeing is, therefore, crucial for global prosperity – necessitating their continuous monitoring and management in the workplace. Although a cross-cultural job satisfaction scale has been specifically developed and validated to help gauge the wellbeing of tech workers, christened JSST, it lacked an implementation guideline. This lack of implementation guidelines for the JSST questionnaire can stifle its practicality and, by extension, the wellbeing of Tech workers. The aim of this study, therefore, is to design an implementation guideline for JSST. The implementation guideline was designed using descriptive statistics and algorithmic specification. Adopting a self-assessment online survey on the original Five-point Likert JSST Questionnaire, this study also demonstrated the implementation of the guideline. 276 valid Tech workers’ job satisfaction self-assessment data solicited globally using the JSST questionnaire was employed to demonstrate the guideline’s feasibility. Overall, the job satisfaction index of the global tech workers has been estimated to fall into the third quartile of satisfaction, Q3, which is low. This low satisfaction index may account for the high turnover and turn-away in the global Tech industry. A notable outcome of this study is the seamless JSST implementation scheme, which is not only effective but also highly adaptable. This scheme can be tailored for the implementation of any multi-faceted psychometric scale, making it a versatile tool for assessing employee wellbeing. The automation for web accessibility of the JSST implementation scheme is encouraged.
ANALYSIS FROM 1980 TO 2018 OF TIDAL OBSERVATION DATA FOR ASSESSING THE STABILITY OF TIDAL CONSTANTS FOR PRIMARY PORT
Authors: Morakinyo Barnabas O. 
Published: January 2025

Tidal analysis involves the computation of tidal constants (phase lag (g) and amplitude (H)) of tidal constituents at a location. This study focuses on the assessment of the stability of g and H for the Bonny port which is the only standard tidal port in Nigeria. Monthly analysis of tidal observations was carried out with 1980, 1994 and 2018 year’s data using Least Squares Method (LSM) of Harmonic Analysis with MATLAB programming codes. The observation equation technique of LSM is adopted; the dimension of the Normal (N) matrix equations obtained for the monthly analysis is 72 56 i.e. 72 rows, and 56 columns. The N matrix is inverted and gave results for mean sea level (MSL) and g and H of 28 primary constituents of tide. Four major constituents of tide (M2, S2, K1 and O1) remain stable throughout the analysis. The mean of g and H obtained for each year was observed to be almost equal to the mean obtained from the three-year data. The maximum residuals and spreads of the computed g and H over the period of study show that g and H at Bonny are stable and that results from accurately analyze one-month data observation can be employed for tidal prediction for several years. Therefore, it can be concluded that the g and H for M2, S2, K1 and O1 are stable and that the type of tide (F) at Bonny port is semidiurnal since the computed F is 0.16 which is 0.25.