bluuebunny/crossref_metadata_2025_split huggingface dataset:
Signaling sustainability: Can it entice business angels' willingness to invest?
Authors: Shahid Subhan , Liouka Ioanna , Deligianni Ioanna 
Published: November 2023

AbstractDespite increasing attention to sustainability as a source of new business opportunities, current research on new ventures has hardly considered this factor with respect to access to funding. This paper examines the role of new venture sustainability signals on business angels' willingness to invest. Specifically, it considers the effects of third‐party sustainability certification and the self‐proclaimed label of sustainable entrepreneurship as congruent reputational signals for inducing angel investors' willingness to invest. Three studies were conducted using a 2 × 2 between‐subject experimental design on certification and label conditions, respectively, in two samples from the Amazon MTurk crowdsourcing marketplace and one from business angels. Results show that early‐stage ventures would use such signals in their sustainability exemplification strategy to convey quality and prestige and eventually improve their chances of raising business angel funding. Implications for theory and practice are discussed.
Deconvolution of synthetic mRNA expression: Nucleoside chemistry alters translatability
Authors: Moradian Hanieh , Schwestka Marko , Roch Toralf , Gossen Manfred 
Published: November 2023

AbstractRecent technological advances in the production of in vitro transcribed messenger RNA (IVT‐mRNA) facilitate its clinical use as well as its application in basic research. In this regard, numerous chemical modifications, which are not naturally observed in endogenous mRNA, have been implemented primarily to address the issue of immunogenicity and improve its biological performance. However, recent findings suggested pronounced differences between expression levels of IVT‐mRNAs with different nucleoside modifications in transfected cells. Given the multistep process of IVT‐mRNA delivery and subsequent intracellular expression, it is unclear which step is influenced by IVT‐mRNA chemistry. Here, we deconvolute this process and show that the nucleoside modification does not interfere with complexation of carriers, their physicochemical properties, and extracellular stability, as exemplified by selected modifications. The immediate effect of mRNA chemistry on the efficiency of ribosomal protein synthesis as a contributor to differences in expression was quantified by in vitro cell‐free translation. Our results demonstrate that for the nucleoside modifications tested, translatability was the decisive step in determining overall protein production. Also of special importance for future work on rational selection of tailored synthetic mRNA chemistries, our findings set a workflow to identify potentially limiting, modification‐dependent steps in the complex delivery process.
Updated systematic review of the effects of exercise on understudied health outcomes in cancer survivors
Authors: Sturgeon Kathleen M. , Kok Dieuwertje E. , Kleckner Ian R. , Guertin Kristin A. , McNeil Jessica , Parry Traci L. , Ehlers Diane K. , Hamilton Andrew , Schmitz Kathryn , Campbell Kristin L. , Winters‐Stone Kerri 
Published: November 2023

AbstractIntroductionThe American College of Sports Medicine provided guidelines for exercise prescriptions in cancer survivors for specific cancer‐ and treatment‐related health outcomes. However, there was insufficient evidence to generate exercise prescriptions for 10 health outcomes of cancer treatment. We sought to update the state of evidence.MethodsWe conducted a systematic review of these 10 understudied health outcomes (bone health, sleep, cardiovascular function, chemotherapy‐induced peripheral neuropathy (CIPN), cognitive function, falls and balance, nausea, pain, sexual function, and treatment tolerance) and provided an update of evidence.ResultsWhile the evidence base for each outcome has increased, there remains insufficient evidence to generate exercise prescriptions. Common limitations observed across outcomes included: variability in type and quality of outcome measurement tools, variability in definitions of the health outcomes, a lack of phase III trials, and a majority of trials investigating breast or prostate cancer survivors only.ConclusionWe identified progress in the field of exercise oncology for several understudied cancer‐ and treatment‐related health outcomes. However, we were not able to generate exercise prescriptions due to continued insufficient evidence base. More work is needed to prescribe exercise as medicine for these understudied health outcomes, and our review highlights several strategies to aid in research acceleration within these areas of exercise oncology.
Gamified cryptocurrency and rewards: Consumer behaviour during uncertain earnings
Authors: Ahsan Zaid Bin , Gupta Agam 
Published: November 2023

AbstractThe accentuation of cryptocurrency, non‐fungible tokens and gamification of platforms has led to rewards being awarded, in the form of cryptocurrencies, that are formed by the platforms themselves and traded over the marketplace. These play‐to‐earn gamified platforms have witnessed a rise in participation, leading to increased investments by consumers, engagement, threats, and subsequent volatility. This paper tries to decipher consumer behaviour over the nascent gamified platform of a play‐to‐earn game, Axie Infinity, due to its fluctuating and subsequent depreciation of cryptocurrency, that act as rewards. This volatility from the resultant rewards over the platform brings about an uncertainty in the users' engagement, which has been part of our investigation in this study. The data was gathered through semi‐structured interviews of 20 participants picked from the official server of Axie Infinity on the social media platform of Discord. A thematic analysis based on a descriptive phenomenological approach was conducted on this data which generated findings that were centred around the continued use of action and rewards, resolution of participation through accumulation of rewards and optimism. The study contributes by highlighting and substantiating the component of optimism in the theory of reinforcement‐uncertainty, that characterises repetitive uncertain events, specifying it for uncertain rewards over investment risks that have been undertaken by consumers. Based on these findings, this study discusses how optimism is crucial in the continuation of engagement and outlines how it can be used in the facilitation of positive consumer behaviour over a gamified platform.
Water‐Based Synthesis of β‐Sheet‐Like Supramolecular Metallohydrogel Organized by Using a Native Ultrashort Peptide Sequence
Authors: Inada Asuka , Motomura Aki , Oshima Tatsuya 
Published: November 2023

AbstractDesigning supramolecular hydrogels using short peptides is challenging. To control self‐assembly, a certain amount of organic solvent is typically added to the system, or the short peptide is modified with a functional group that is hydrophobic, hydrophilic, or highly coordinative. We discovered that l‐His‐l‐Ile‐l‐Thr (HIT), a very short unmodified “native” tripeptide, selectively responds to Cu2+ ions in pure water to form a transparent supramolecular metallohydrogel. Circular dichroism analysis revealed that Cu2+ ions, but no other metal species, caused HIT to change from a random‐coil‐like to a β‐sheet‐like structure. Other spectroscopic methods were used to characterize the properties of the supramolecular metallohydrogel. These results are expected to facilitate the development of native short peptides as advanced functional biomaterials.
Skeletal Editing through Molecular Recombination of 2H‐Indazoles to Azo‐Linked‐Quinazolinones
Authors: Bhattacharjee Suvam , Hajra Alakananda 
Published: November 2023

AbstractA new protocol by the combinatory use of two equivalent of indazoles starting material with one being the carbon source via its C3‐reactivity and the other, the coupling partner has been developed for the selectfluor‐mediated single atom skeletal editing of 2H‐indazoles. The azo‐linked‐2,3‐disubstituted quinazolin‐4‐one derivatives were obtained through a carbon atom insertion between the two nitrogens of the indazole ring and simultaneous oxidation at C3 position of both indazole moieties. Mechanistic investigations reveal that the amidic carbonyl oxygen of the product is derived from water and the reaction proceeds through in‐situ generated N‐centred indazolone radical intermediate.
Copper‐Mediated N‐Trifluoromethylation of O‐Benzoylhydroxylamines
Authors: Fleetwood Thomas D. , Kerr William J. , Mason Joseph 
Published: November 2023

AbstractThe use of trifluoromethyl containing compounds is well established within medicinal chemistry, with a range of approved drugs containing C−CF3 and O−CF3 moieties. However, the utilisation of the N−CF3 functional group remains relatively unexplored. This may be attributed to the challenging synthesis of this unit, with many current methods employing harsh conditions or less accessible reagents. A robust methodology for the N‐trifluoromethylation of secondary amines has been developed, which employs an umpolung strategy in the form of a copper‐catalysed electrophilic amination. The method is operationally simple, uses mild, inexpensive reagents, and has been used to synthesise a range of novel, structurally complex N−CF3 containing compounds.
Chalcogen and Hydrogen Bond Team up in Driving Anion⋅⋅⋅Anion Self‐Assembly
Authors: Beccaria Roberta , Dhaka Arun , Calabrese Miriam , Pizzi Andrea , Frontera Antonio , Resnati Giuseppe 
Published: November 2023

AbstractH‐selenite anions (HSeO3−) form in the solid unprecedented anionic supramolecular chains wherein single units are assembled via alternating short Se⋅⋅⋅O and H⋅⋅⋅O contacts. Crystallographic analyses and computational studies (the quantum theory of “atoms‐in‐molecules”, QTAIM, and the noncovalent interaction plot, NCIPlot) consistently prove the attractive nature of these chalcogen bonds (ChBs) and hydrogen honds (HBs), the Janus‐type character of HSeO3− anions which act as both donors and acceptors of ChB and HB, and the possible stability of anion dimers in solution. The effectiveness of the ChBs herein described may lead to consider the HSeO3− moiety as a new entry in the toolbox of crystal engineering based on ChB.
Metal‐organic framework‐derived two‐dimensional in‐plane Janus catalysts promoting oxygen electroreduction to hydrogen peroxide
Authors: Jiang Lili , Sun Yuntong , Duan Jingjing , Chen Sheng 
Published: November 2023

AbstractWe use MOFs material as precursor to synthesize carbon based two‐dimensional (2D) materials loaded with In2S3−In2O3 (In−S−O) nanoparticles. The In−S−O nanoparticles have exhibited Janus architecture composed of two compounds with different crystal structures that are combined in‐plane on 2D carbon material surface. The excellent properties of this in‐plane Janus material include 2D nanoarchitecture and its Janus properties formed by combining two different crystal structures. It has exhibited excellent electrochemical performances due to its abundant electrochemical active sites and large specific surface area. According to experiments, the electron transfer number of the material for two‐electron oxygen reduction is about 2.4, and the hydrogen peroxide yield is 32 mg/h cm2. In the further test of liquid flow electrolytic cell, the yield can reach up to 172 mg/h cm2.
Evaluation of Market‐Available Snack Chip Packaging: Modified Atmosphere Packaging, Water Activity, Mechanical Properties, and Efficiency of Packaging Material Use
Authors: Schmackler Theresa , Müller Kajetan , Tybussek Thorsten , Jesdinszki Marius , Sängerlaub Sven 
Published: November 2023

AbstractSnack chips come in a wide variety. They are sensitive to oxidation and water vapor absorption. Therefore, it is valuable to look closer at the current packaging situation. For this study, 108 snack chip products packaged in pouches and cans were analysed. The most often used oil was sunflower oil followed by a blend of vegetable oils. Unexpectedly, only at 44 of the tested products modified atmosphere packaging (MAP) was used. This result is important since many packagings could be designed in future with less oxygen barrier. On the other side, use of MAP might potentially increase quality and shelf‐life of chips currently without MAP. The packaging material efficiencies of pouches were found to be better than that of cans. It increased with higher filling quantities. In the best case the ratio was 50 g chips per 1 g packaging material for a pouch with a filling quantity of 300 g. For bigger packages, a lower relative cost could be observed, especially for pouches.
Expanding Diterpene Complexity and Diversity via Photoinduced Ring Distortions
Authors: Luz Tibaldi‐Bollati María , Nicotra Viviana , Oksdath‐Mansilla Gabriela , García Manuela E. 
Published: November 2023

AbstractNatural products and their semi‐synthetic derivatives undoubtedly constitute an important source of therapeutic agents. Their importance lies in their own origin and evolution, since they have great chemical diversity, biochemical specificity, and pharmacological properties. Currently, there is a renewed interest in the development of methodologies capable of efficiently modifying the chemical structure of these bioactive platforms. In this work, the photoderivatization of the diterpene solidagenone was performed using a complexity‐to‐diversity‐oriented approach. By exploring [2+2]‐photocycloaddition, photoinduced‐hydrogen abstraction, and photoxygenation reactions, a set of solidagenone derivatives was obtained, showing different ring fusions, side chain rearrangements, and modifications of the original furan ring's substitution pattern. The derivatives obtained were characterised by NMR methodologies. To evaluate the structural diversity of the labdane‐derived compounds, their physicochemical properties, structural similarity, and chemical space were analysed. These results suggest that photochemical reactions are a useful tool for performing ring distortion transformations, generating derivatives of natural compounds with wide diversity, structural complexity, and with potential biological properties.
Postbariatric surgery hypoglycemia: Nutritional, pharmacological and surgical perspectives
Authors: Rossini Giovanni , Risi Renata , Monte Lavinia , Sancetta Biagio , Quadrini Maria , Ugoccioni Massimiliano , Masi Davide , Rossetti Rebecca , D’Alessio Rossella , Mazzilli Rossella , Defeudis Giuseppe , Lubrano Carla , Gnessi Lucio , Watanabe Mikiko , Manfrini Silvia , Tuccinardi Dario 
Published: November 2023

AbstractPost‐bariatric hypoglycaemia (PBH) is a metabolic complication of bariatric surgery (BS), consisting of low post‐prandial glucose levels in patients having undergone bariatric procedures. While BS is currently the most effective and relatively safe treatment for obesity and its complications, the development of PBH can significantly impact patients' quality of life and mental health. The diagnosis of PBH is still challenging, considering the lack of definitive and reliable diagnostic tools, and the fact that this condition is frequently asymptomatic. However, PBH's prevalence is alarming, involving up to 88% of the post‐bariatric population, depending on the diagnostic tool, and this may be underestimated. Given the prevalence of obesity soaring, and an increasing number of bariatric procedures being performed, it is crucial that physicians are skilled to diagnose PBH and promptly treat patients suffering from it. While the milestone of managing this condition is nutritional therapy, growing evidence suggests that old and new pharmacological approaches may be adopted as adjunct therapies for managing this complex condition.
Long‐term evolution of the structure of the St. Lawrence (Canada) marine ecosystem in the context of climate change and anthropogenic activities: An isotopic perceptive
Authors: Rioux Ève , Cabrol Jory , Lesage Véronique 
Published: November 2023

AbstractDocumenting long‐term changes in the trophic structure of food webs and how species respond to these changes is essential to forecast their vulnerability and resilience to environmental stressors. Over the past decades, the St. Lawrence marine ecosystem (Canada) has experienced major changes in its physical, chemical, and biological conditions from overfishing, acoustic and chemical pollution, climate change, and the increased abundance of some top predators. These changes have likely affected the trophodynamics of the ecosystem, and are suspected to have deleterious effects on endangered species of mammals and other components of the ecosystem, such as blue whales (Balaenoptera musculus), fin whales (B. physalus), and beluga (Delphinapterus leucas). This study examined the trophic structure of the St. Lawrence marine ecosystem, including the isotopic niche of various species, over two periods of contrasting pressures from anthropogenic and climatic stressors (1995–2003 vs. 2019–2021). Stable isotope ratios were measured in 1240 samples of 21 species of marine invertebrates, fishes, and mammals sampled during both periods. A significant change in the isotopic value and niche position between periods is observed in most of the sampled species. While the direction of change and effect size were not uniform among species, these changes confirmed that substantial modifications in community structure have occurred over time. Niche overlap decreased considerably among some of the pelagic and demersal fishes, and among whale species during the most recent period. Combined with a concomitant reduction in niche breadth in several species, these observations suggested that resource sharing was limited among these species. This study highlighted some degree of dietary plasticity in several species, and a long‐term change in the trophic structure of the St. Lawrence marine ecosystem, with likely effects on diet composition and energetics of several populations, including endangered species.
Warming and top‐down control of stage‐structured prey: Linking theory to patterns in natural systems
Authors: Davidson Andrew T. , Stunkle C. Ryland , Armstrong Joshua T. , Hamman Elizabeth A. , McCoy Michael W. , Vonesh James R. 
Published: November 2023

AbstractWarming has broad and often nonlinear impacts on organismal physiology and traits, allowing it to impact species interactions like predation through a variety of pathways that may be difficult to predict. Predictions are commonly based on short‐term experiments and models, and these studies often yield conflicting results depending on the environmental context, spatiotemporal scale, and the predator and prey species considered. Thus, the accuracy of predicted changes in interaction strength, and their importance to the broader ecosystems they take place in, remain unclear. Here, we attempted to link one such set of predictions generated using theory, modeling, and controlled experiments to patterns in the natural abundance of prey across a broad thermal gradient. To do so, we first predicted how warming would impact a stage‐structured predator–prey interaction in riverine rock pools between Pantala spp. dragonfly nymph predators and Aedes atropalpus mosquito larval prey. We then described temperature variation across a set of hundreds of riverine rock pools (n = 775) and leveraged this natural gradient to look for evidence for or against our model's predictions. Our model's predictions suggested that warming should weaken predator control of mosquito larval prey by accelerating their development and shrinking the window of time during which aquatic dragonfly nymphs could consume them. This was consistent with data collected in rock pool ecosystems, where the negative effects of dragonfly nymph predators on mosquito larval abundance were weaker in warmer pools. Our findings provide additional evidence to substantiate our model‐derived predictions while emphasizing the importance of assessing similar predictions using natural gradients of temperature whenever possible.
rCRUX: A rapid and versatile tool for generating metabarcoding reference libraries in R
Authors: Curd Emily E. , Gal Luna , Gallego Ramon , Silliman Katherine , Nielsen Shaun , Gold Zachary 
Published: November 2023

AbstractThe sequencing revolution requires accurate taxonomic classification of DNA sequences. The key to making accurate taxonomic assignments is curated, comprehensive reference barcode databases. However, the generation and curation of such databases has remained challenging given the large and continuously growing volumes of both DNA sequence data and novel reference barcode targets. Monitoring and research applications require a greater diversity of specialized gene regions and targeted taxa than are currently curated by professional staff. Thus, there is a growing need for an easy‐to‐implement computational tool that can generate comprehensive metabarcoding reference libraries for any bespoke locus. We address this need by reimagining CRUX from the Anacapa Toolkit and present the rCRUX package in R which, like its predecessor, relies on sequence homology and PCR primer compatibility instead of keyword searches to avoid limitations of user‐defined metadata. The typical workflow involves searching for plausible seed amplicons (get_seeds_local() or get_seeds_remote()) by simulating in silico PCR to acquire a set of sequences analogous to PCR products containing a user‐defined set of primer sequences. Next, these seeds are used to iteratively blast search seed sequences against a local copy of the National Center for Biotechnology Information (NCBI)‐formatted nt database using a taxonomic rank‐based stratified random sampling approach (blast_seeds()). This results in a comprehensive set of sequence matches. This database is dereplicated and cleaned (derep_and_clean_db()) by identifying identical reference sequences and collapsing the taxonomic path to the lowest taxonomic agreement across all matching reads. This results in a curated, comprehensive database of primer‐specific reference barcode sequences from NCBI. Databases can then be compared (compare_db()) to determine read and taxonomic overlap. We demonstrate that rCRUX provides more comprehensive reference databases for the MiFish Universal Teleost 12S, Taberlet trnl, fungal ITS, and Leray CO1 loci than CRABS, MetaCurator, RESCRIPt, and ecoPCR reference databases. We then further demonstrate the utility of rCRUX by generating 24 reference databases for 20 metabarcoding loci, many of which lack dedicated reference database curation efforts. The rCRUX package provides a simple‐to‐use tool for the generation of curated, comprehensive reference databases for user‐defined loci, facilitating accurate and effective taxonomic classification of metabarcoding and DNA sequence efforts broadly.
Concave microlens arrays with tunable curvature for enhanced photodegradation of organic pollutants in water: A non‐contact approach
Authors: Lu Qiuyun , Li Yanan , Kassim Kehinde , Xu Ben Bin , Gamal El‐Din Mohamed , Zhang Xuehua 
Published: November 2023

AbstractSolar‐driven photodegradation for water treatment faces challenges such as low energy conversion rates, high maintenance costs, and over‐sensitivity to the environment. In this study, we develop reusable concave microlens arrays (MLAs) for more efficient solar photodegradation by optimizing light distribution. Concave MLAs with the base radius of  μm are fabricated by imprinting convex MLAs to polydimethylsiloxane elastomers. Concave MLAs possess a non‐contact reactor configuration, preventing MLAs from detaching or being contaminated. By precisely controlling the solvent exchange, concave MLAs are fabricated with well‐defined curvature and adjustable volume on femtoliter scale. The focusing effects of MLAs are examined, and good agreement is presented between experiments and simulations. The photodegradation efficiency of organic pollutants in water is significantly enhanced by 5.1‐fold, attributed to higher intensity at focal points of concave MLAs. Furthermore, enhanced photodegradation by concave MLAs is demonstrated under low light irradiation, applicable to real river water and highly turbid water.image