bluuebunny/crossref_metadata_2025_split huggingface dataset:
Methodological quality of systematic reviews in dentistry including animal studies: a cross-sectional study
Authors: Menne Max C. , Su Naichuan , Faggion Clovis M. 
Published: December 2023

Abstract
Background
The overall confidence in the results of systematic reviews including animal models can be heterogeneous. We assessed the methodological quality of systematic reviews including animal models in dentistry as well as the overall confidence in the results of those systematic reviews.

Material & methods
PubMed, Web of Science and Scopus were searched for systematic reviews including animal studies in dentistry published later than January 2010 until 18th of July 2022. Overall confidence in the results was assessed using a modified version of the A MeaSurement Tool to Assess systematic Reviews (AMSTAR-2) checklist. Checklist items were rated as yes, partial yes, no and not applicable. Linear regression analysis was used to investigate associations between systematic review characteristics and the overall adherence to the AMSTAR-2 checklist. The overall confidence in the results was calculated based on the number of critical and non-critical weaknesses presented in the AMSTAR-2 items and rated as high, moderate, low and critical low.

Results
Of initially 951 retrieved systematic reviews, 190 were included in the study. The overall confidence in the results was low in 43 (22.6%) and critically low in 133 (70.0%) systematic reviews. While some AMSTAR-2 items were regularly reported (e.g. conflict of interest, selection in duplicate), others were not (e.g. funding: n = 1; 0.5%). Multivariable linear regression analysis showed that the adherence scores of AMSTAR-2 was significantly associated with publication year, journal impact factor (IF), topic, and the use of tools to assess risk of bias (RoB) of the systematic reviews.

Conclusion
Although the methodological quality of dental systematic reviews of animal models improved over the years, it is still suboptimal. The overall confidence in the results was mostly low or critically low. Systematic reviews, which were published later, published in a journal with a higher IF, focused on non-surgery topics, and used at least one tool to assess RoB correlated with greater adherence to the AMSTAR-2 guidelines.
Identification of ACBD3 as a new molecular biomarker in pan-cancers through bioinformatic analysis: a preclinical study
Authors: Ma Xinyue , Huang Shu , Shi Huiqin , Luo Rui , Luo Bei , Tan Zhenju , Shi Lei , Zhang Wei , Yang Weixing , Zhong Xiaolin , Lü Muhan , Chen Xia , Tang Xiaowei 
Published: December 2023

Abstract
Background
Acyl-CoA-binding domain-containing 3 (ACBD3) is a multifunctional protein, that plays essential roles in cellular signaling and membrane domain organization. Although the precise roles of ACBD3 in various cancers remain unclear. Thus, we aimed to determine the diverse roles of ACBD3 in pan-cancers.

Methods
Relevant clinical and RNA-sequencing data for normal tissues and 33 tumors from The Cancer Genome Atlas (TCGA) database, the Human Protein Atlas, and other databases were applied to investigate ACBD3 expression in various cancers. ACBD3-binding and ACBD3-related target genes were obtained from the STRING and GEPIA2 databases. The possible functions of ACBD3-binding genes were explored using Gene Ontology (GO) and Kyoto Encyclopedia of Genes and Genomes (KEGG) enrichment analyses. We also applied the diagnostic value and survival prognosis analysis of ACBD3 in pan-cancers using R language. The mutational features of ACBD3 in various TCGA cancers were obtained from the cBioPortal database.

Results
When compared with normal tissues, ACBD3 expression was statistically upregulated in eleven cancers and downregulated in three cancers. ACBD3 expression was remarkably different among various pathological stages of tumors, immune and molecular subtypes of cancers, cancer phosphorylation levels, and immune cell infiltration. The survival of four tumors was correlated with the expression level of ACBD3, including pancreatic adenocarcinoma, adrenocortical carcinoma, sarcoma, and glioma. The high accuracy in diagnosing multiple tumors and its correlation with prognosis indicated that ACBD3 may be a potential biomarker of pan-cancers.

Conclusion
According to our pan-cancer analysis, ACBD3 may serve as a remarkable prognostic and diagnostic biomarker of pan-cancers as well as contribute to tumor development. ACBD3 may also provide new directions for cancer treatment targets in the future.
Effectiveness and safety of different doses of febuxostat compared with allopurinol in the treatment of hyperuricemia: a meta-analysis of randomized controlled trials
Authors: Xie Hong , Hu Nan , Pan Ting , Wu Jun-Cai , Yu Miao , Wang Deng-Chao 
Published: December 2023

Abstract
Background
The prevalence of hyperuricemia has increased steadily with the continuous improvement of living standards. Some studies have reported the clinical effectiveness and safety of different doses of febuxostat in comparison with allopurinol in hyperuricemia treatment, but the sample sizes of the studies have been small, and the results have been inconsistent. We designed this meta-analysis to evaluate the effectiveness and safety of different doses of febuxostat compared with allopurinol in the treatment of hyperuricemia.

Methods
The Cochrane Library, Embase, PubMed, Web of Science and ClinicalTrials.gov databases were searched to identify randomized controlled trials (RCTs) comparing the use of febuxostat and allopurinol for the treatment of hyperuricemia. The effectiveness and safety of different doses of febuxostat and allopurinol in treating hyperuricemia were assessed using meta-analysis.

Results
A total of 11 randomized controlled trials were included in the meta-analysis. The results of the meta-analysis showed that the percentage of patients achieving serum uric acid levels of 6.0 mg/dL or less was higher among patients taking febuxostat (80 mg/d) than among patients taking allopurinol (200–300 mg/d) [RR = 1.79, 95% CI (1.55, 2.08), P < 0.00001]. However, there was no statistically significant difference in the percentage of patients achieving serum uric acid levels of 6.0 mg/dL or less between febuxostat (40 mg/d) and allopurinol (200–300 mg/d) [RR = 1.10, 95% CI (0.93, 1.31), P = 0.25]. There was also no statistically significant difference in the incidence of gout between the febuxostat (40 mg/d) and allopurinol (200–300 mg/d) [RR = 0.97, 95% CI (0.64, 1.49), P = 0.91] or between the febuxostat (80 mg/d) and allopurinol (200–300 mg/d) [RR = 1.13, 95% CI (0.81, 1.58), P = 0.48].No significant difference in the incidence of major adverse reactions as observed between the febuxostat (40 mg/d) and allopurinol (200–300 mg/d) [RR = 1.16; 95% CI (0.43, 3.16), P = 0.77] or between the febuxostat (80 mg/d) and allopurinol (200–300 mg/d) [RR = 1.06; 95% CI (0.79, 1.42), P = 0.70]. The incidence of adverse cardiovascular events did not differ significantly between the febuxostat (40 mg/d) and allopurinol (200–300 mg/d) [RR = 1.30; 95% CI (0.57, 2.95), P = 0.53] or between the febuxostat (80 mg/d) and allopurinol (200–300 mg/d) [RR = 1.79; 95% CI (0.74, 4.32), P = 0.20].

Conclusions
Febuxostat (80 mg/d) was associated with a higher percentage of patients achieving serum uric acid levels of 6.0 mg/dL or less than allopurinol (200–300 mg/d), however, febuxostat (80 mg/d) did not exhibit better efficacy in reducing the incidence of gout. More attention should be devoted to the adverse reactions caused by an increase in febuxostat doses.
Adaptive overcurrent protection scheme coordination in presence of distributed generation using radial basis neural network
Authors: Uma Uma Uzubi , Nmadu Daniel , Ugwuanyi Nnaemeka , Ogah Ogah Ekechi , Eli-Chukwu Ngozi , Eheduru Marcellinus , Ekwue Arthur 
Published: December 2023

AbstractThe operational performance of conventional overcurrent protection relay coordination connected to a distribution network is adversely affected by the penetration of distributed generators (DG) at different buses in the network. To address this problem, this paper proposes a novel adaptive protection coordination scheme using a radial basis function neural network (RBFNN), which automatically adjusts the overcurrent relay settings, i.e., time setting multiplier (TSM) and plug setting multiplier (PSM) based on the penetration of DGs. Short circuit currents and voltages measured at different buses are acquired using the remote terminal units (RTU) connected to different buses within the terminal network. Communication between the various remotes and local end station RTUs is through hybrid communication systems of fiber optic and power line communication system modules. The new adaptive overcurrent protection scheme is applied to the IEEE 33-bus distribution network with and without DGs, for single and multi-DG penetration using both the ETAP and MATLAB software. The simulation results show the proposed scheme significantly improves the protection coordination.
Acoustic metascreen for broadband wavefront manipulation with stationary phase gradients
Authors: Liu Chen , Wang Nengyin , Gu Zhongming , Li Yong , Zhu Jie 
Published: December 2023

Abstract
The development of an efficient acoustic metascreen utilizing artificial micro-structured metamaterials holds paramount importance for the manipulation of acoustic wavefronts. However, the expansive broadband capability of such metascreens is often compromised due to the variations in amplitude and phase profiles of the conceived structures at different frequencies. To address this issue, we introduce a broadband metascreen composed of several interconnected acoustic cavities. The concept is substantiated by the theoretical explication of the abrupt cross-section tube model. The resultant metascreen demonstrates high transmission efficiency and maintains a consistent phase profile over a wide frequency band, which implies that the relative phase disparities amongst neighboring pixels are retained at uniform intervals across the entire frequency spectrum, enabling the distinct broadband functionality of the metascreens developed. Through both simulations and experimental measurements, we exhibit the ability of the metascreen to manipulate the wavefront of transmitted waves, accomplishing acoustic focusing and self-bending across multiple frequencies. Our research paves the way for a novel and multifunctional method to manipulate broadband wavefronts through transmissive grooved acoustic metamaterial, offering a practical and promising methodology to develop advanced acoustic apparatuses.
Geology, Power, and the Planetary
Authors: Whitington Jerome , Oguz Zeynep 
Published: December 2023

Abstract
What conditions of possibility have emerged for learning to live on a new earth? This special section builds on scholarship in the environmental humanities, critical Black studies, and geophilosophy to explore how emergent ways of becoming human are forged in relation to powerful earth dynamics, even while earth’s powers are constitutive of contemporary forms of domination. Geologizing Sylvia Wynter’s understanding of being human as a praxis, it proposes that earth as praxis (a) provides a diagnosis of the deeply embedded forms of power that have been materialized, over several centuries, in the earthly conditions of life itself; and (b) represents a critical potential for creating new ways to live on earth through the practical exploration of geosocial relations. We highlight three modes of earth praxis. Inhuman territorializations calls attention to the landscapes and earthy matter subjected to racializing and territorializing modes of power. In turn, such practices participate in the constitution of dehumanized, racialized, and dispossessed bodies and peoples. Becoming geological refers to the ways human forms of living have become shot through with earth system dynamics, mineralogical relations, and energetic possibilities, to the extent that people cannot be who they are without these pervasive anthropogenic geologies. Finally, planetary predicaments helps diagnose the politically vital and collective but deeply unequal and nonhomogeneous conditions of the present. Earth as praxis offers an analytical grip on emerging planetary earth relations that breaks with abstract, universalizing categories, and is capable of diagnosing the wide range of today’s violent, creative, and liberatory planetary practices.
Consolations of the Earth
Authors: Whitington Jerome 
Published: December 2023

Abstract
This article looks toward nineteenth-century earth sciences with attention to their humanistic themes. In the early decades of the century, multiple lines of evidence concretized a humanistic experience of man as a finite being with a contingent and accidental planetary existence. Geological humanism refers to the way that themes of earthly existence routinely influenced the status and meaning of being human, culturally and within the sciences, with the collapse of Enlightenment aesthetics of symmetry, purpose, and order in the late eighteenth century. While earth sciences recast humanistic themes in empirical terms, by the latter half of the nineteenth century scientists also regularly articulated prophecies of secular extinction or demise that were resolved, but only partly, both with reference to a long-standing racial schema and through routine consolations that a planet modified by human activity would be a better earth. Coal played a particular role in mediating between earth and atmosphere, mineral and life, and matter and energy. This article details several of these secular consolations offered to popular audiences by prominent climate scientists to show that the earth was far from being understood as a stable domain of nature that could be taken for granted.
Discurso do Analista e Democracia em Risco: Por Que o Psicanalista Não Pode Ser Bolsonarista?
Authors: Silva Angela , Ferreira Livia 
Published: December 2023

O objetivo deste trabalho é responder por que um psicanalista não pode ser bolsonarista. Para isso, partimos da articulação entre a noção de pós-verdade e verdade sob uma perspectiva psicanalítica. Por meio de uma revisão teórica, discorremos sobre tais perspectivas tendo como cenário o contexto brasileiro das últimas eleições presidenciais e da gestão da pandemia de COVID-19. Articulamos pós-verdade e verdade a uma terceira noção, a autoverdade, a partir da discussão sobre a importância que assume o discurso do psicanalista quando este se posiciona diante dos outros discursos propostos por Lacan, sobretudo em um contexto de risco à democracia. Concluímos que a partir da dimensão clínica, eixo central de sua prática, o psicanalista não pode ser bolsonarista porque, ao ocupar o lugar de a, não estabelece com o outro uma relação de manutenção de um gozo destrutivo, gozo que não leva em conta a responsabilidade subjetiva cujas incidências mais prementes se dão sobre a vivência da alteridade.
Desenhar, escrever e contar: qualidade de vida da criança e adolescente com condição crônica
Authors: Santos Lívia Grazielle Benevides dos , Pontes Thaís Rodriguez , Nunes Michelle Darezzo Rodrigues , Silva-Rodrigues Fernanda Machado , Silva Liliane Faria da , Pacheco Sandra Teixeira Araújo 
Published: December 2023

Objetivo: compreender por meio da técnica Desenhar, escrever e contar como a condição crônica influencia na qualidade de vida infantojuvenil; e analisar o uso da técnica nessa população. Método: estudo qualitativo, descritivo e exploratório. Participaram onze crianças e adolescentes com condição crônica entre sete e dezessete anos. A coleta de dados ocorreu mediante entrevista semiestruturada, com auxílio da técnica Desenhar, escrever e contar, em um Hospital público. Para análise dos dados utilizou-se a análise de conteúdo temática de Bardin. Resultados: emergiram três categorias que evidenciam diversas alterações na qualidade de vida dessa clientela, com destaque para o comprometimento físico, emocional e social que impacta nas de experiências que compõem a infância e a adolescência. A técnica Desenhar, escrever e contar foi um facilitador e enriqueceu a coleta de dados. Considerações finais: a técnica escolhida possibilitou identificar a qualidade de vida prejudicada da criança e adolescente com condição crônica.
Habilidades sociais na especialidade da enfermagem em oncologia: estudo qualitativo
Authors: Crespo Maria da Conceição Albernaz , Barbosa Nathália Araújo , Bittencourt Nair Caroline Cavalcanti de Mendonça , Lucas Pedro Ricardo Martins Bernardes , Silva Ítalo Rodolfo , Silva Marcelle Miranda da 
Published: December 2023

Objetivo: compreender o significado das habilidades sociais atribuído por enfermeiros especialistas em enfermagem em oncologia. Método: estudo qualitativo, exploratório, que aplicou a Teoria Fundamentada nos Dados e o Interacionismo Simbólico. Participaram 14 enfermeiros de um dos grupos amostrais, especialistas em oncologia, de hospital oncológico. Aplicamos a entrevista semiestruturada, on-line, de maio de 2021 a dezembro de 2022. A análise seguiu a codificação aberta, axial e integração, e aplicamos o paradigma da codificação. Resultados: a categoria paradigmática ‘condição do fenômeno’ é apresentada face o aspecto semântico e de reconhecimento da aplicação das habilidades sociais. A categoria Percepções e significados das habilidades sociais para enfermeiros oncologistas alicerçou-se nas subcategorias: reagindo ao termo, e atribuindo significados e valores às habilidades sociais na especialidade da enfermagem em oncologia. Conclusão: os enfermeiros reconhecem as habilidades sociais e sua importância na oncologia. Desse modo, reitera-se a importância da articulação teórico-prático para qualificar a prática na oncologia.
Ratio of hemoglobin to mean corpuscular volume: A new index for discriminating between iron deficiency anemia and thalassemia trait
Authors: Yao Qing-Chun , Zhai Hui-Li , Wang Hou-Cai 
Published: December 2023

BACKGROUND
Iron deficiency anemia (IDA) and thalassemia trait (TT) are the most common microcytic and hypochromic anemias. Differentiation between mild TT and early IDA is still a clinical challenge.
AIM
To develop and validate a new index for discriminating between IDA and TT.
METHODS
Blood count data from 126 patients, consisting of 43 TT patients and 83 IDA patients, was retrospectively analyzed to develop a new index formula. This formula was further validated in another 61 patients, consisting of 48 TT patients and 13 IDA patients.
RESULTS
The new index is the ratio of hemoglobin to mean corpuscular volume. Its sensitivity, specificity, accuracy, Youden’s Index, area under the receiver operating characteristic curve, and Kappa coefficient in discriminating between IDA and TT were 93.5%, 78.4%, 83.3%, 0.72, 0.97, and 0.65, respectively.
CONCLUSION
This new index has good diagnostic performance in discriminating between mild TT and early IDA. It requires only two results of complete blood count, which can be a very desirable feature in under-resourced scenarios.
Influence of standardized nursing intervention combined with mindfulness stress reduction training on the curative effect in patients with acute pancreatitis
Authors: Li Sha , Yin Dan , Guo Xiao-Chun 
Published: December 2023

BACKGROUND
Acute pancreatitis (AP) is a common inflammatory disease of the pancreas with high mortality rates. It is of great significance to take scientific intervention measures for patients with AP in time.
AIM
To explore the effect of standardized nursing combined with mindfulness stress reduction training on the curative effect, negative emotion, and quality of life in patients with acute pancreatitis.
METHODS
A total of 80 patients with acute pancreatitis admitted to The First People's Hospital of Jiangxia District Hospital from May 2021 to May 2023 were randomly divided into control group and observation group (n = 40). Patients in control group were given the standardized nursing intervention, and the observation group were given standardized nursing plus mindfulness stress reduction training intervention. The time of clinical symptom disappeared or improved, complication occurrence rate, emotional state, and quality of life score of the two groups were observed and compared.
RESULTS
In comparison with the control group, the bowel sound recovery time, ventosity and abdominal pain improvement time, and venting and cacation time in observation group were shorter, and the total incidence rate of complications was reduced, showing statistically significant difference (P < 0.05). The scores of anxiety and depression in observation group were lower than those in control group (P < 0.05). Serum levels of tumour necrosis factor alpha, interleukin (IL)-6, IL-1β and IL-8 in observation group were lower than those in control group (P < 0.05). The scores of life quality in physiology, psychology, environment and social relations in observation group were higher than those in control group, and the differences were statistically significant (P < 0.05).
CONCLUSION
The application of standardized nursing intervention combined with mindfulness stress reduction training in patients with acute pancreatitis has a definite effect, which can help to ameliorate the clinical symptoms, anxiety and depression of patients, reduce the incidence rate of complications, and improve the prognosis of patients.
Vericiguat treatment of heart failure: A systematic review and meta-analysis
Authors: Yang Heng , Luo Chao , Lan Wan-Qi , Tang Yan-Hua 
Published: December 2023

BACKGROUND
Heart failure (HF), an end-stage manifestation of various cardiac diseases, poses an enormous economic and health burden on society. Vericiguat may be an effective drug in the treatment of HF.
AIM
To explore by meta-analysis the efficacy and safety of Vericiguat in treating chronic heart failure.
METHODS
Databases, including PubMed, EMBASE, Web of Science, and Cochrane Library, were searched to collect all published randomized controlled trials (RCTs) on Vericiguat treatment of chronic heart failure from the earliest electronic records to those published in March 2023. Two investigators independently screened the literature according to inclusion and exclusion criteria, evaluated the quality of the studies, and extracted valid data before conducting a meta-analysis using RevMan5.4.
RESULTS
Four RCTs with 5919 patients were included, and the meta-analysis showed that treatment with 10 mg Vericiguat reduced the incidence of the primary endpoint (a composite of cardiovascular mortality and first heart-failure-related hospitalization) in patients with chronic heart failure compared to placebo [relative risk (RR) = 0.91, 95% confidence interval (CI): 0.85–0.98, P = 0.01], and reduced the incidence of heart-failure-related hospitalization (RR = 0.92, 95%CI: 0.84–1.00, P = 0.05). However, for the incidence of cardiovascular and all-cause death, there were no significant differences between the Vericiguat and placebo groups. In addition, the two groups did not show significant differences in blood pressure, heart rate, and Kansas Cardiomyopathy Questionnaire physical limitation score. In terms of safety, 10 mg Vericiguat did not increase the risk of adverse effects in patients with chronic heart failure. Vericiguat may increase the risk of symptomatic hypotension (RR = 1.17, 95%CI: 0.98–1.39, P = 0.08) and syncope (RR = 1.18, 95%CI: 0.90–1.55, P = 0.24), but not significantly.
CONCLUSION
Vericiguat (10 mg) was more effective than placebo in treating patients with chronic heart failure and had a better safety profile.