bluuebunny/crossref_metadata_2025_split huggingface dataset:
Novel tetrahydroisoquinolines as DHFR and CDK2 inhibitors: Synthesis, characterization, anticancer activity and antioxidant properties
Authors: Sayed Eman M. , Bakhite Etify A. , Hassanien Reda , Farhan Nasser , Aly Hanan F. , Morsy Salma G. , Hassan Nivin A. 
Published: December 2023

Abstract
In this study, we synthesized new 5,6,7,8-tetrahydroisoquinolines and 6,7,8,9-tetrahydrothieno[2,3-c]isoquinolines based on 4-(N,N-dimethylamino)phenyl moiety as expected anticancer and/or antioxidant agents. The structures of all synthesized compounds were confirmed by spectroscopic data and elemental analyses. We evaluated the anticancer activity of these compounds towards two cell lines: A459 (lung cancer cell line) and MCF7 (breast cancer cell line). All tested compounds showed moderate to strong anti-cancer activity towards the two cell lines. Compound 7e exhibited the strongest cytotoxic activity against A549 cell line (IC50: 0.155 µM) while compound 8d showed the strongest one against MCF7 cell line (IC50: 0.170 µM) compared with doxorubicin. In addition, we examined the impact of compounds 7e and 8d on the growth of A549 and MCF7 cell lines, employing flow cytometery and an Annexin V-FITC apoptotic assay. Compound 7e caused cell cycle arrest at the G2/M phase with a 79-fold increase in apoptosis of A459 cell line. In contrast, compound 8d caused cell cycle arrest at the S phase with a 69-fold increase in apoptosis of MCF7 cell line. Furthermore, we studied the activity of these compounds as enzyme inhibitors against several enzymes. Our findings showed that compound 7e is a potent CDK2 inhibitor with IC50 of 0.149 µM, compared to the Roscovitine control drug which showed an IC50 of 0.380 µM. We also found that compound 8d is a significant DHFR inhibitor with an IC50 of 0.199 µM, compared to Methotrexate control drug which showed IC50 of 0.131 µM. Evaluation the antioxidant properties of ten compounds was also included and promising results obtained.
The impact of a European unemployment benefit scheme on labour supply and income distribution
Authors: Lefebvre Mathieu , Simon Agathe 
Published: December 2023

Abstract

This paper investigates the effect of introducing a European unemployment insurance scheme (EMU-UI) on the labour supply and income distribution in the Eurozone countries. We simulate various reform scenarios based on structural estimation of the labour supply and using the European tax-benefit microsimulation model EUROMOD. The results show that the labour supply response to the introduction of an EMU-UI differs substantially across countries and depends on the design of the EMU-UI. We find that a flat EMU-UI scheme implies a strong work disincentive but reduces poverty. On the contrary, a fully contribution-related EMU-UI system limits much more the distortions on the labour market in most countries but has limited effects on poverty and inequality. An EMU-UI with a common replacement rate, articulated with floor and ceiling amounts, would allow for upward convergence as it would strongly reduce poverty and inequality in several countries while not inducing substantial labour supply reduction.
Shooting left or right in the National Hockey League: Likely influence of batting in baseball and different success levels
Authors: Grondin Simon , Rioux Pier-Alexandre , Fortin-Guichard Daniel 
Published: December 2023

Abstract

This study addresses the question of the lateral preference of the National Hockey League players. The shooting preference, left or right, was analysed as a function of the origin of four groups of players that are from the USA, Canada, Europe, or Russia. The analysis reveals that the players from the USA are more likely to shoot right than players from other countries. This finding, which applies to both forward and defense players, is attributed to the potential higher participation to baseball during youth of American players. Compared to defense players from other groups, defense players from the USA have a higher number of shots per game and a higher goal-to-assist ratio, a finding argued to depend on the playing style coming with the placement of hands on the stick. The study also shows that for wingers shooting left, those playing on the right wing have more goals or points per game than those playing on the left wing; and that European forward players have a better differential (+/-) than American and Canadian forward players. The study reveals the cultural influence on the preference in a bimanual asymmetric task and the impact of this preference on ice hockey performances.
Tropical Race 4 and Race 1 strains causing Fusarium wilt of banana infect and survive in Heliconiaspecies and ornamental bananas
Authors: Parte Einar Martínez de la , Meijer Harold J.G. , Quesada Mauricio Gúzman , Carr Claudiana , Jimmenez Silvia Masis , Perez-Vicente Luis , Kema G.H.J 
Published: December 2023

Abstract
Fusarium wilt of banana (FWB), caused by soilborne Fusarium spp., is a major global threat to the cultivation of bananas. In addition to persistent chlamydospores, weeds are a reservoir of the causal agents. However, it remains unclear whether other Zingiberales species, which are grown in the same geographic regions, also can serve as hosts for Fusarium spp. that cause FWB. Greenhouse assays were conducted to investigate whether Fusarium phialophorum (Race 1; pathogenic to Gros Michel banana) and Fusarium odoratissimum (TR4; pathogenic to Cavendish banana) can infect three Heliconia species, two ornamental banana species or Musa textilis (abacá). Heliconia latispatha, Musa balbisiana, and Musa coccinea displayed external symptoms after inoculation with TR4, while inoculation with Race 1 caused symptoms in H. latispatha, H. psittacorum, M. coccinea, and M. velutina. Isolates recovered from distinct organs of all studied plant species were characterized and re-isolated strains caused FWB symptoms in Gros Michel and Cavendish banana plants, and their rhizome discolored area scores were similar to the reference strains. The susceptibility of some ornamental species and the presence of Fusarium strains as asymptomatic endophytes in others, with remaining pathogenicity, call for a revision of the race nomenclature and the current containment protocols for FWB.
A Video Recommendation Model Based on Enhanced Graph Convolutional Network
Authors: Delgado Booker , Nieves Maritza , Whitman Greta 
Published: December 2023

Abstract
The recommendation system infers user interests by collecting their historical behavior, thereby generating a list of recommendations. The goal of a video recommendation system is to fulfill user needs by recommending videos that align with their interests. In such a system, the relevant input data consists of the user's historical video-watching behavior sequence, where the order of videos in the sequence represents the chronological relationship of user video consumption. The output data is a probabilistic model that calculates the likelihood of a given user watching a specific video in the next viewing session. Once this model is obtained, probabilities can be computed for all candidate videos, and the recommendation list can be generated by sorting these probabilities in descending order. Here, we propose a video recommendation model based on graph convolutional networks. This recommendation model constructs a heterogeneous graph that includes user and video nodes and behavior edges. It builds an embedding layer to obtain representation vectors for users and videos, designs vectors to characterize users' long-term and short-term interests, and introduces a prediction layer to estimate the probability of a user watching a video.
Effect of Temperature on Thermal Characterization of Al 6061 Matrix Composites Reinforced with Fine Silicon Nitride Particles
Authors: J Kumaraswamy 
Published: December 2023

Abstract
In the current study, stirred casting has been used to process Al6061 reinforced with Si3N4 small particles in a variety of configurations. Tests using energy dispersive spectrometers have confirmed that Al6061 and Si3N4 are the main components of the treated compounds. Si3N4 composition has been added to Al6061 at different weight concentrations of 0, 3, 6, 9, and 12%. A study using optical microscopy has been conducted to determine the composite material configuration. We have tried to investigate the microstructures and thermal behaviour of composites reinforced with Si3N4 at varying weight fractions in this work. After Si3N4 was added to Al6061, the microstructure, thermal conductivity increased by 23.33%, and the coefficient of thermal expansion decreased by 20.73%. The thermal characteristics of Al6061 reinforced with Si3N4 fine particles were superior to those of Al6061 without Si3N4 reinforcement.
DIGITAL TECHNOLOGIES IN LOGISTICS AND SUPPLY CHAIN MANAGEMENT
Authors: Rodchenko Volodymyr , Prus Yuliia 
Published: December 2023

The aim of the research is to summarize current trends in the use of digital technologies in logistics and supply chain management, to study the nature of their impact on the development of the logistics system of an economic entity. The article summarizes the main trends in the digitalization of supply chains and logistics in trade and industry. The methodical aspects of digital transformation of supply chains were considered. It is established that the emphasis in the organization and management of supply chains has shifted towards the transformation of traditional chains into the space of the digital economy. The article identifies promising areas and challenges for the use of digital technologies in logistics and supply chain management: the Internet of Things, blockchain, cloud services, augmented reality, robots, drones, and 3D printing. The trends in the development of digital technologies are explored, as their integration into global supply chains can accelerate, simplify and reduce the cost of the supply process at almost all stages. Digital technologies that improve the process of goods movement in supply chains are presented in the article in terms of logistics in the context of managing the relevant flows: material, information, financial, service. The state of development of cooperation between the main types of economic activities that produce technological and digital technologies and types of economic activities that provide logistics and supply management in the European Union was assessed.
Gambaran Pengetahuan Masyarakat Tentang Penyakit Tidak Menular (PTM) Di Puskesmas Olak Kemang Kota Jambi
Authors: Kusdiyah Erny , Fakhri Ayushia Generosa , Sugiarti Ratna 
Published: December 2023

ABSTRAK

Latar Belakang: Berdasarkan hasil pencatatan dan pelaporan pada program PTM di Puskesmas Olak Kemang bulan Januari-Juni 2023 jumlah pasien yang diskrining yaitu 803 orang (26,7%) dari target sasaran sebesar 6.213 orang (70%). Oleh karena itu perlu dilakukan analisis permasalahan terhadap capaian skrining PTM di Puskesmas Olak Kemang Kota Jambi.
Tujuan: Mengetahui gambaran dan permasalahan rendahnya capaian skrining PTM di Puskesmas Olak Kemang.
Metode: Penelitian ini merupakan penelitian deskriptif yang menggunakan mix method berupa wawancara dan kuesioner. Wawancara dilakukan pada petugas pemegang program PTM dan kader posbindu PTM. Kuesioner diberikan kepada Masyarakat dan kader Posbindu PTM.
Hasil: Dari 30 responden dan wawancara pemegang program PTM didapatkan beberapa faktor yang menyebabkan rendahnya capaian skrining PTM di Puskesmas Olak Kemang, di antaranya pengetahuan Masyarakat tentang PTM rendah (63,3%), petugas yang melakukan skrining hanya satu orang, kurangnya media informasi, jarak rumah ke lokasi posbindu jauh, kurangnya penyuluhan mengenai PTM, dan kegiatan skrining hanya terbatas di waktu kerja.
Kesimpulan: Pada penelitian ini ditemukan masalah yang diprioritaskan adalah rendahnya capaian skrining PTM di Puskesmas Olak Kemang Bulan Januari-Juni 2023 sebesar 26,7%..

Kata kunci: Skrining PTM, Puskesmas, Jambi
PEMERIKSAAN STATUS GIZI DAN PENYULUHAN KESEHATAN ANAK MENGENAI PENGARUH GADGET PADA PERKEMBANGAN ANAK
Authors: Halim Rita , Aryanty Nindya 
Published: December 2023

ABSTRACT
The process of growth and development can be considered from two aspects that describe physical changes and developments that describe a more complex structure and function of the body. This activity aims to screen the nutritional status of children and educate parents about the effect of gadgets on children's development. The outreach activities which were planned to be carried out directly due to the COVID 19 pandemic conditions were changed to a Health Webinar which was held on September 27, 2020 with 103 participants. The webinar participants in this activity did not only come from Jambi city but also from outside Jambi province such as Malang, Bali, Java, Surabaya, Aceh, Banyuwangi, Palembang, Surakarta, Jakarta, and Bangka Belitung.

Keywords: nutritional status, growth and development, gadgets

ABSTRAK
Proses tumbuh kembang dapat diperhatikan dari dua aspek yaitu tumbuh yang menggambarkan perubahan fisik dan perkembangan yang menggambarkan kemampuan struktur dan fungsi tubuh yang lebih komplek. Kegiatan ini bertujuan untuk melakukan skrining status gizi pada anak dan mengedukasi para orangtua tentang pengaruh gadget pada perkembangan anak. Kegiatan penyuluhan yang rencananya akan dilakukan secara langsung tetapi karena kondisi pandemi COVID 19 dialihkan menjadi Webinar Kesehatan yang dilaksanakan pada tanggal 27 September 2020 dengan jumlah peserta 103 orang. Peserta webinar pada kegiatan ini bukan hanya berasal dari kota Jambi tapi juga dari luar provinsi Jambi seperti Malang, Bali, Jawa, Surabaya, Aceh, Banyuwangi, Palembang, Surakarta, Jakarta, dan Bangka Belitung.

Kata kunci : status gizi, tumbuh kembang, gadget
Kliniko-sitopatologi Apusan Serviks di Puskesmas Muara Bulian Kabupaten Batang Hari Provinsi Jambi
Authors: Quzwain Fairuz Chatib , Dewi Hasna , Ayu Utami Erisca , Syauqy Ahmad 
Published: December 2023

Kanker serviks merupakan kanker yang paling banyak menyebabkan kematian dinegara-negara berkembang seperti Indonesia maupun diseluruh dunia. Berdasarkan data GLOBOCAN tahun 2012 kanker serviks menempati urutan yang ke-7 secara global dari penilaian segi angka kejadian (menempati urutan yang ke urutan ke 6 di negara kurang berkembang) serta urutan yang ke-8 sebagai penyebab kematian. Untuk itu, diperlukan upaya pencegahan atau deteksi dini penyakit ini sehingga tidak ditemukan pada stadium lebih buruk. Tujuan penelitian dilakukan untuk mengetahui bagaimana gambaran klinikositopatologi apusan serviks di wilayah kerja Puskesmas Muaro Bulian Provinsi Jambi. Penelitian ini menggunakan teknik potong lintang, menggunakan klasifikasi Bethesda 2014 sebagai acuan. Data yang diambil merupakan data primer klinis dan gambaran sitopatologi apusan serviks dengan teknik pap smear. Didapatkan 29 data yang lengkap. Didapatkan rata-rata usia sebesar 43.5 tahun, paling banyak berstatus multipara (75.8%) multipara dan tidak menggunakan metode kontrasepsi apapun atau lainnya (75.8%).Hasil sitopatologi yang paling banyak adalah servisitis kronis non spesifik dan ditemukan perubahan berupa ASCUS pada urutan ketiga, yang ditemukan justru pada wanita dengan tanpa keluhan dan usai menarche,sehingga disimpulkan perlu dilakukan secara rutin pemeriksaan apusan serviks yang dapat ditemukan perubahan lesi walaupun tanpa keluhan.
UPAYA PEMBENTUKAN CREATIVE DOCTORPRENEUR BAGI GENERASI MILENIAL MELALUI EDUKASI INOVASI HEALTH-PRENEURSHIP BERBASIS DIGITAL DAN INVESTASI
Authors: Miftahurrahmah Miftahurrahmah , Hz Tia Wida Ekaputri , Ayudia Esa Indah , Justitia Budi 
Published: December 2023

Latar belakang: Kondisi pandemi Covid-19 membatasi interaksi dokter dan pasien serta berdampak pada kesejahteran masyarakat Indonesia, sehingga saat ini wawasan entrepreneurship sangat dibutuhkan. Terjadi perubahan cara pandang dokter generasi milineal dengan mengusung pentingnya wawasan health-preneurship berbasis digital.
Tujuan: Pembentukan creative doctorpreneur bagi generasi milenial melalui edukasi tentang inovasi health-preneurship berbasis digital dan investasi.
Metode: Acara ini dilangsungkan secara webinar dengan mengundang narasumber di bidang doctorpreneur berbasis digital. Pretest dan posttest serta kuesioner evaluasi kegiatan diberikan kepada peserta webinar. Setelah dilakukan pemaparan oleh narasumber, diberikan kesempatan untuk diskusi kepada peserta. Analisa data digunakan uji Wilcoxon untuk mengetahui peningkatan pengetahuan.
Hasil: Peserta yang berpartisipasi dalam kegiatan ini sebanyak 330 orang yang terdiri dari 102 mahasiswa tahun keempat, 90 mahasiswa tahun ketiga, 61 mahasiswa tahun kedua dan 77 mahasiswa tahun pertama. Terdapat perbedaan yang signifikan nilai pre-test dan post-test mahasiswa (P-value=0,00). Hasil evaluasi kegiatan menunjukkan mayoritas peserta menyatakan kegiatan seminar sangat baik dan baik.
Kesimpulan: Kegiatan webinar ini terbukti dapat meningkatkan pengetahuan mahasiswa tentang creative doctorpreneur bagi generasi milenial.
Kata kunci: doctorpreneur, health-preneurship, generasi milineal, berbasis digital
PENYULUHAN EMO-DEMO UNTUK MENINGKATKAN PENGETAHUAN IBU TENTANG STUNTING DI DESA SARI MULYA KABUPATEN TEBO PROVINSI JAMBI
Authors: Guspianto Guspianto 
Published: December 2023

ABSTRACT
Stunting is a condition of failed growth in children due to chronic malnutrition or recurrent infectious diseases, especially in the 1000 first day of life period (1000 HPK) so that the child was shorter for age. Stunting has an impact on failure to growth, cognitive development barriers, and metabolic disorders. The cause of stunting were multi-factors, one of which was low knowledge. This activity aims to increase mothers' knowledge about stunting and the importance of the 1000 HPK period, exclusive breastfeeding and complementary breastfeeding in preventing stunting. The method used was counseling with the Emo-Demo technique to target pregnant women and toddler mothers. Evaluation results based on the pre test and post test showed an increase in mother's knowledge. It is recommended to the Puskesmas to increase the intensity of health education about stunting so that stunting prevention and treatment programs can be more accepted and well adopted by the community.
Keywords: stunting, 1000 HPK, exclusive breastfeeding, MP-ASI

ABSTRAK
Stunting adalah kondisi gagal pertumbuhan pada anak akibat kekurangan asupan gizi dalam waktu yang lama atau sakit infeksi berulang terutama pada periode 1000 hari pertama kehidupa (1000 HPK) sehingga anak lebih pendek untuk usianya. Stunting berdampak pada gagal tumbuh, hambatan perkembangan kognitif dan motorik, dan gangguan metabolisme. Penyebab terjadinya stunting bersifat multi faktor salah satunya adalah rendahnya pengetahuan ibu. Kegiatan pengabdian kepada masyarakat ini bertujuan untuk meningkatkan pengetahuan ibu khususnya tentang stunting, pentingnya periode 1000 HPK, pemberian ASI Eksklusif dan MP-ASI dalam mencegah stunting. Metode yang digunakan adalah penyuluhan dengan teknik Emo-Demo terhadap sasaran ibu hamil dan ibu yang memiliki balita. Hasil evaluasi berdasarkan pre test dan post test menunjukkan adanya peningkatan pengetahuan ibu. Disarankan kepada pihak Puskesmas untuk meningkatkan intensitas penyuluhan kesehatan tentang stunting sehingga program pencegahan dan penanganan stunting dapat lebih diterima dan adopsi dengan baik oleh masyarakat.
Kata kunci: stunting, 1000 HPK, ASI Eksklusif, MP-ASI
“CETING ASIK” SEBAGAI UPAYA PENCEGAHAN BALITA STUNTING DI WILAYAH KERJA PUSKESMAS PELABUHAN DAGANG
Authors: Ayu Sari Gustia , Haryati Haryati , Fakhrurazi MZ , Meinarisa Meinarisa 
Published: December 2023

ABSTRACT
Stunting in Indonesia is one of the health problems faced by infants and toddlers. Jambi Province itself has a chronic nutritional problem (stunting) which is of particular concern. Optimal breastfeeding is very important to prevent malnutrition in infants and toddlers. Important interventions in stunting prevention. Interventions on stunting are aimed at improving the nutritional status of infants and toddlers, preventing stunting, especially during the early stages of life. The reason for the low coverage of exclusive breastfeeding in the Pelabuhan Dagang Health Center is that public awareness in encouraging increased breastfeeding is still relatively low. For this reason, an activity was carried out to encourage an increase in exclusive breastfeeding outcomes, namely "Ceting Asik: Cegah Stunting Dengan Asi Eksklusif".
Keywords: Ceting Asik, Exclusive Breastfeeding, Stunting, Community Health Center

ABSTRAK
Stunting di Indonesia merupakan salah satu masalah kesehatan yang dihadapi untuk bayi dan balita. Provinsi Jambi sendiri memiliki masalah gizi kronis (stunting) yang menjadi perhatian khusus. Pemberian ASI yang optimal sangat penting untuk mencegah kekurangan gizi pada bayi dan balita. Intervensi penting dalam pencegahan stunting. Intervensi pada stunting ditujukan untuk memperbaiki status gizi bayi dan balita, mencegah stunting terutama pada masa awal kehidupan. Penyebab masih rendahnya cakupan ASI eksklusif di wilayah kerja Puskesmas Pelabuhan Dagang yakni kesadaran masyarakat dalam mendorong peningkatan pemberian asi masih relatif rendah. Untuk itu dilakukan sebuah kegiatan untuk mendorong peningkatan capaian ASI Eksklusif yaitu “ceting Asik: Cegah Stunting Dengan Asi Eksklusif”.
Kata Kunci: Ceting Asik, ASI Ekslusif, Stunting, Puskesmas
The Brand Value of Earnings: An Event Study of Consumer Responses to Earnings Announcements
Authors: Kimbrough Michael D. , Paharia Neeru , Wang Xu , Wei Sijing 
Published: December 2023

ABSTRACT
We provide evidence from the first short-window event study of consumers’ perceptual responses to earnings announcements using daily consumer perception data. We document a positive association between the change in consumers’ overall perceptions of a brand at the time of the earnings announcement and the earnings surprise—that is, a positive consumer earnings response coefficient (CERC). CERC is larger when there is greater traditional news or social media activity, indicating that news dissemination is an important channel for consumers to respond to earnings news. Moreover, CERC varies based on brand and consumer characteristics. Changes in consumer perceptions at the time of the earnings announcement are positively associated with changes in purchase consideration and intent and with changes in realized future sales growth. To maximize identification, we document a positive and statistically significant CERC in a controlled experiment. Our findings demonstrate the importance of earnings to an important stakeholder.
Data Availability: Data are available from the sources cited in the text.
JEL Classifications: M31; M41; G14.
Operating Leverage and Stock Returns under Different Aggregate Funding Conditions
Authors: García-Feijóo Luis , Jensen Tyler K. , Koch Paul D. 
Published: December 2023

ABSTRACT
We document time-varying interrelations between aggregate funding conditions and the impact of operating leverage (OL) on stock returns. OL represents a primitive source of risk, which helps explain the well established unconditional relation between OL and future returns. However, the outperformance of firms with high OL occurs exclusively during periods of unconstrained funding. Although high OL represents operational inflexibility, when the Fed eases funding constraints, improved capital availability mitigates this inflexibility. Consequently, investors bid up the prices of stocks with high OL when aggregate funding constraints are loosened to reflect their lower risk and greater expected performance in unconstrained periods.
Data Availability: Data are available from the public sources cited in the text.
JEL Classifications: E22; E44; E52; G11; G12; G14.