bluuebunny/crossref_metadata_2025_split huggingface dataset:
Congenital small bowel obstruction: Prenatal detection and outcome
Authors: Heinrich H. , Pijpers A. G. H. , Linskens I. H. , van Leeuwen E. , Schattenkerk L. D. Eeftinck , Derikx J. P. M. , Pajkrt E. 
Published: November 2023

AbstractObjectiveTo evaluate and compare the outcome of fetuses and neonates with congenital small bowel obstructions (SBO), evaluate the screening performance of prenatal ultrasound for SBO and identify possible risk factors for adverse outcomes.MethodsAll cases referred to the Amsterdam University Medical Centers between 2007 and 2021 for a prenatal suspected SBO, supplemented by cases of postnatal diagnosis of SBO, were included. The primary outcome was survival after 24 weeks of gestation until the first year of life.Results147 cases of SBO were included with a survival rate of 86.2% (119/138) after 24 weeks of gestation until the first year of age. Additional structural or chromosomal anomalies were found to have an increased risk of adverse outcomes. Intrauterine fetal demise occurred in 10/147 (6.8%) cases and 9/147 (6.1%) cases died during postnatal follow‐up. The overall positive predictive value of all prenatally diagnosed cases was 91.5%. Surgical correction was performed in 123/128 (96.0%) of the live‐born cases.ConclusionsCongenital SBO has an overall favorable prognosis, but the outcome is negatively impacted by the possible presence of additional structural or chromosomal anomalies. Fetal monitoring in the early third trimester should be considered, since all cases of Intrauterine fetal demise occurred between 30 and 35 weeks of gestation.
Confronting racial inequity in health and education: Supporting students with sickle cell disease
Authors: Jones Paul C. , Schmitt Ara J. , Nayyar Akshita , Brandon Conaway R. , Eyler Kelly , Franklin Kirstin , Hodge Clyniece 
Published: November 2023

AbstractThe racialized history of sickle cell disease (SCD) continues to contribute to racial disparities in healthcare and education. In the context of the racialized history of SCD, we begin by outlining subtypes of SCD and explaining that SCD is associated with chronic pain, silent cerebral infarct, overt stroke, and poor overall well‐being—all of which have implications for school functioning. A literature search was conducted to identify significant meta‐analyses, systematic reviews, and empirical articles to inform school psychologists' evaluation, service delivery, and decision‐making practices when working with students with SCD. Common negative neuropsychological and psychoeducational outcomes associated with SCD are reviewed. Finally, recommended culturally responsive practices are discussed, ahead of a conclusion that contains a call to action for school psychologists.
Human collagen decorating microneedle patches for transdermal therapy
Authors: Zheng Kaikai , Zhou Teng , Xiao E. , Wei Qiang , Zhao Changsheng 
Published: November 2023

AbstractCollagen, the major structural protein in various tissues, is an ideal material for tissue regeneration. However, the collagen molecules cannot penetrate across the skin barrier due to their large molecular weight. It is necessary to develop new methods of delivery for promoting the collagen‐based therapy. Microneedle patches have been used in drug delivery applications as an alternative to traditional puncture delivery. In this study, the human collagen decorating microneedle patch was developed to deliver the collagen into the skin tissue, as the human‐source collagen can overcome the immunogenicity of animal‐source collagens in regenerative applications. The human collagen is usually limited by its source. Here, the collagen is derived from an allogeneic extracellular matrix expressed by human stem cells in vitro. The collagen was then loaded on the tip of the microneedle to achieve a high‐loading dose and efficient delivery. The experimental results proved that the microneedles were sharp and rigid enough to pierce the skin, which has the potential to be used for subcutaneous tissue regeneration. Moreover, the fabrication process was simple and effective to realize large‐scale production.
PROMISE Registry: A prostate cancer registry of outcomes and germline mutations for improved survival and treatment effectiveness
Authors: Paller Channing J. , Barata Pedro C. , Lorentz Justin , Appleman Leonard J. , Armstrong Andrew J. , DeMarco Tiffani A. , Dreicer Robert , Elrod Jo Ann B. , Fleming Mark , George Christopher , Heath Elisabeth I. , Hussain Maha H. A. , Mao Shifeng , McKay Rana R. , Morgans Alicia K. , Orton Matthew , Pili Roberto , Riedel Elyn , Saraiya Biren , Sigmond Joelle , Sokolova Alexandra , Stadler Walter M. , Tran Christina , Macario Natalie , Vinson Jacob , Green Rebecca , Cheng Heather H. ,   PROMISE Trial Investigators
Published: November 2023

AbstractBackgroundRecently approved treatments and updates to genetic testing recommendations for prostate cancer have created a need for correlated analyses of patient outcomes data via germline genetic mutation status. Genetic registries address these gaps by identifying candidates for recently approved targeted treatments, expanding clinical trial data examining specific gene mutations, and understanding effects of targeted treatments in the real‐world setting.MethodsThe PROMISE Registry is a 20‐year (5‐year recruitment, 15‐year follow‐up), US‐wide, prospective genetic registry for prostate cancer patients. Five thousand patients will be screened through an online at‐home germline testing to identify and enroll 500 patients with germline mutations, including: pathogenic or likely pathogenic variants and variants of uncertain significance in genes of interest. Patients will be followed for 15 years and clinical data with real time patient reported outcomes will be collected. Eligible patients will enter long‐term follow‐up (6‐month PRO surveys and medical record retrieval). As a virtual study with patient self‐enrollment, the PROMISE Registry may fill gaps in genetics services in underserved areas and for patients within sufficient insurance coverage.ResultsThe PROMISE Registry opened in May 2021. 2114 patients have enrolled to date across 48 US states and 23 recruiting sites. 202 patients have met criteria for long‐term follow‐up. PROMISE is on target with the study's goal of 5000 patients screened and 500 patients eligible for long‐term follow‐up by 2026.ConclusionsThe PROMISE Registry is a novel, prospective, germline registry that will collect long‐term patient outcomes data to address current gaps in understanding resulting from recently FDA‐approved treatments and updates to genetic testing recommendations for prostate cancer. Through inclusion of a broad nationwide sample, including underserved patients and those unaffiliated with major academic centers, the PROMISE Registry aims to provide access to germline genetic testing and to collect data to understand disease characteristics and treatment responses across the disease spectrum for prostate cancer with rare germline genetic variants.
Front Cover Image
Authors: Wang Liying , He Limei , Zhu Xiaoming , Zhang Jinwen , Li Na , Fan Jingfang , Li Huafeng , Sun Xiaoji , Zhang Lijiao , Lin Yongling , Wu Kongming 
Published: November 2023

The cover image is based on the Research Article Large‐area field application confirms the effectiveness of toxicant‐infused bait for managing Helicoverpa armigera (Hübner) in maize fields by Liying Wang et al., https://doi.org/10.1002/ps.7756.image
Exploring the hormetic effects of radiation on the life table parameters of Spodoptera frugiperda
Authors: Hao Zheng , Jin Tao , Yang Sheng‐Yuan , Lin Yu‐Ying , Zhong Hao , Peng Zheng‐Qiang , Ma Guang‐Chang 
Published: November 2023

BACKGROUNDSpodoptera frugiperda, a global agricultural pest, can be effectively controlled through the sterile insect technique. However, exposure to low‐dose radiation below the sterilization threshold may induce hormetic effects. Here, the biphasic aspects of the fertile progeny population of S. frugiperda were analyzed using an age‐stage, two‐sex life table after dosing male and female pupae with 10–350 Gy gamma radiation.RESULTSThe parental sterilizing dose for 6‐day‐old female and male pupae was 200 and 350 Gy, respectively. The total longevity, pre‐adult survival rate, net reproduction rate, and intrinsic growth rate of the offspring population increased with decreasing radiation doses from 250 to 10 Gy. Offspring population of parents treated with low doses of 10–100 Gy showed better life table parameters compared to non‐irradiated controls. Females and males fecundity irradiated with 10, 50, and 100 Gy and 10 Gy, respectively, exceeded controls, producing 2339.4, 2726.4, 2311, and 2369 eggs, as opposed to 1802.9 eggs produced by the controls. Males irradiated with 10 Gy displayed the highest intrinsic rates of increase and net reproduction rate, at 0.1709 and 682.3, respectively. Projections from the survival rate and fecundity indicated that female and male S. frugiperda populations after 10 Gy irradiation may grow considerably faster than the controls.CONCLUSIONThis study explores the hormetic effects of low‐dose radiation on S. frugiperda through life table analysis, while providing enhancements for utilizing substerilizing gamma dose in a modified F1 sterility technique. © 2023 Society of Chemical Industry.
Older British migrants in Spain: Return patterns and intentions post‐Brexit
Authors: Giner‐Monfort Jordi , Hall Kelly 
Published: November 2023

AbstractAfter the Brexit referendum results, there may have been fears that a significant part of the British population in Spain, one of the largest outside the Commonwealth, would return to the United Kingdom. This paper uses different sources to assess whether, on the one hand, such a return movement has existed and, on the other hand, whether it could exist in the future. To do so, we analyse data from the Spanish Population Register (Padrón) and the Residential Variation Statistics (EVR) from 2003 to 2021, and a survey carried out in 2020 of 643 British people over 55 years of age living in Spain. In relation to the registry data, it has been observed that the return movement after Brexit has not been as significant as might be expected at a time of great uncertainty. Only in 2021 it was detected an increase in return movements, especially above the age of 75, probably caused by the end of the application of the Withdrawal Agreement. On the other hand, the survey results show that the intention to return is lower than in other similar surveys that have been carried out in the past, even in another COVID‐19 outbreak scenario. Moreover, this intention to return is especially related to variables linked to insertion, such as not being properly registered or owning a property in the United Kingdom, among other variables.
Cellular neurobiology of hyperforin
Authors: Bouron Alexandre 
Published: November 2023

AbstractHyperforin is a phloroglucinol derivative isolated from the medicinal plant Hypericum perforatum (St John's wort, SJW). This lipophilic biomolecule displays antibacterial, pro‐apoptotic, antiproliferative, and anti‐inflammatory activities. In addition, in vitro and in vivo data showed that hyperforin is a promising molecule with potential applications in neurology and psychiatry. For instance, hyperforin possesses antidepressant properties, impairs the uptake of neurotransmitters, and stimulates the brain derived neurotrophic factor (BDNF)/TrkB neurotrophic signaling pathway, the adult hippocampal neurogenesis, and the brain homeostasis of zinc. In fact, hyperforin is a multi‐target biomolecule with a complex neuropharmacological profile. However, one prominent pharmacological feature of hyperforin is its ability to influence the homeostasis of cations such as Ca2+, Na+, Zn2+, and H+. So far, the pathophysiological relevance of these actions is currently unknown. The main objective of the present work is to provide an overview of the cellular neurobiology of hyperforin, with a special focus on its effects on neuronal membranes and the movement of cations.
Mid‐level dry air intrusions over the southern Maritime Continent
Authors: Aslam Ashar A. , Schwendike Juliane , Peatman Simon C. , Birch Cathryn E. , Bollasina Massimo A. , Barrett Paul 
Published: November 2023

AbstractPatterns in extreme precipitation across the Maritime Continent in southeast Asia are known to be modulated by many processes, from large‐scale modes of variability such as the Madden–Julian oscillation, to finer‐scale mechanisms such as the diurnal cycle. Transient mid‐level dry air intrusions are an example of a feature not extensively studied over the Maritime Continent, which has the potential to influence rainfall patterns. Here, we show that these dry air intrusions originate from upper level disturbances along the subtropical jet. Mid‐level cyclonic circulation anomalies northwest of Australia from December to February (DJF) intensify westerlies in the southern Maritime Continent, advecting dry air eastward. In contrast, mid‐level anticyclonic circulation anomalies northwest of Australia from June to August (JJA) intensify southern Maritime Continent easterlies, advecting dry air westward. The resultant transport direction of associated air parcels is also dependent on the seasonal low‐level monsoon circulation. Dry air intrusions are important in influencing low‐level wind and rainfall patterns, suppressing rainfall over seas near the southern Maritime Continent in both seasons, as well as over southern Maritime Continent islands in DJF and the Indian Ocean in JJA. In both seasons there is enhanced rainfall to the east of the intrusion, where there is moist return flow to the extratropics. This study highlights the importance of synoptic‐scale extratropical features in influencing meteorological patterns in the Tropics.
Heading control based on extended homogeneous polynomial Lyapunov function
Authors: Huang Yanwei , Lin Feng 
Published: November 2023

AbstractFor the nonlinear parameter‐varying (NPV) model of unmanned surface vehicle with the consideration of the velocities on yaw and surge as well as wave disturbances, a robust control method is proposed based on extended homogeneous polynomial Lyapunov function (EHPLF) to regulate heading for the superior performance on the rapidity, accuracy, and robustness. First, a NPV model of heading error is established to design a general form of a state feedback controller with a robust performance. Second, a Lyapunov matrix with full states and varying parameter is constructed to derive the robust global exponential stability conditions by Euler's homogeneity relation for the NPV system, known as the EHPLF stability conditions. Third, since the EHPLF stability conditions consist of a set of nonlinear coupled inequalities that cannot be directly solved by sum of squares (SOS) toolboxes, they are decoupled with matrix transformations to obtain the EHPLF‐SOS stability conditions, which is solved for the parameters of the state feedback controller. Finally, the simulation results indicate that EHPLF method exhibits a superior performance on dynamic, steady‐state, and robustness.
Why most definitions of modeling competence in science education fall short: Analyzing the relevance of volition for modeling
Authors: Ammoneit Rieke , Göhner Maximilian Felix , Bielik Tom , Krell Moritz 
Published: November 2023

AbstractDefinitions of modeling competence in science education do not yet include noncognitive factors. However, noncognitive factors are central to competence and might thus substantially improve our understanding of modeling competence. In this article, we analyze volition during preservice science teachers' engagement with a black‐box modeling task and its relation to established aspects of modeling competence: metamodeling knowledge, modeling process, and modeling product. A cluster analysis of the occurrence of volition categories resulted in three clusters of volitional behavior. The clusters describe three different volition types: one action‐oriented type applying a self‐regulative strategy and two state‐oriented types applying self‐controlling strategies. Correlation analyses between clusters, volition categories and modeling process variables indicate benefits of the self‐regulative strategy.
6‐(Hydroxymethyl)‐8‐oxo‐4,8‐dihydropyrano[3,2‐b]pyrans as New Tyrosinase Inhibitors and Antioxidant Agents
Authors: Ranjbar Sara , Razmara Sara , Khademian Sara , Malekzadeh Zeinab , Kabiri Maryam , Ghasemi Younes , Khoshneviszadeh Mehdi 
Published: November 2023

AbstractA series of ethyl 2‐amino‐6‐(hydroxymethyl)‐8‐oxo‐4,8‐dihydropyrano[3,2‐b]pyran‐3‐carboxylates (P1‐P13) as annulated kojic acid derivatives were synthesized, and evaluated for their tyrosinase inhibitory activity as well as radical scavenging effect. It was found that derivatives P6 and P9, bearing 3‐chlorophenyl and 4‐hydroxy‐3,5‐dimethoxyphenyl at the C4 position, possessed good tyrosinase inhibitory effects with IC50 values of 52.1±2.3 and 80.7±2.5 μM, respectively. Compound P9 also exhibited remarkable free radical scavenging activity with an EC50 value of 15.3±3.1 μM compared to the standard ascorbic acid (EC50=21.6±1.9 μM). The results of molecular docking analysis exposed that P6 and P9 bind well with the active site of tyrosinase mainly by hydrogen bonds and hydrophobic interactions. In silico studies showed that these molecules fulfilled drug‐likeness rules and possessed acceptable predictive absorption, distribution, metabolism, and excretion features. This study could provide new ideas for developing effective tyrosinase inhibitors and antioxidant agents.
Antimicrobial Properties of Azole Functional Silica Nanocomposites
Authors: Usul Sedef Kaptan , Lüleci Hatice Büşra , Ergüden Bengü , Aslan Ayşe 
Published: November 2023

AbstractSilica nanoparticles have become more attractive due to their surface characteristics, versatility, biocompatibility, and morphological and physicochemical properties. For this reason, their use in biological applications has been expanding in recent years. In this study, after functionalizing silica nanoparticles with glycidyl methacrylate monomer, nanocomposites were formed by attaching 1,2,4‐Triazole, 3‐Amino‐1,2,4‐Triazole, and 5‐Aminotetrazole particles to the surface. Notably, the thermal degradation temperature of all nanocomposites was determined to surpass 200 °C. However, it is worth mentioning that despite the favorable water uptake rates observed for MT(7.64 %) and M3(5.98 %) nanocomposites, MT did not exhibit resistance against Fenton chemicals and experienced degradation. It is important to note that the material loss in M3 nanocomposites is minimal, measuring less than 1 %. In order to reveal the antifungal and antibacterial activity of the synthesized nanoparticles, Minimum inhibitory concentration(MIC), as well as Minimum Fungicidal Concentration(MFC) against the yeast strain Saccharomyces cerevisiae, and Minimum Bactericidal Concentration(MBC) values against bacteria strains, Staphylococcus aureus, Enterococcus faecalis and Escherichia coli were determined. The findings of the study indicated that MP, M3, and M5 nanocomposites displayed a moderate level of antibacterial activity. It is noteworthy, however, that the antibacterial activity diminished when triazole was combined with MP at concentrations exceeding 100 mg/mL.
Kinetically Controlled Nucleation Enabled by Tunable Microfluidic Mixing for the Synthesis of Dendritic Au@Pt Core/Shell Nanomaterials
Authors: Wang Wubin , Wang Yacheng , Zhang Dongtang , Guo Guangsheng , Wang Leyu , Wang Xiayan 
Published: November 2023

AbstractThe nucleation stage plays a decisive role in determining nanocrystal morphology and properties; hence, the ability to regulate nucleation is critical for achieving high‐level control. Herein, glass microfluidic chips with S‐shaped mixing units are designed for the synthesis of Au@Pt core/shell materials. The use of hydrodynamics to tune the nucleation kinetics is explored by varying the number of mixing units. Dendritic Au@Pt core/shell nanomaterials are controllably synthesized and a formation mechanism is proposed. As‐synthesized Au@Pt exhibited excellent ethanol oxidation activity under alkaline conditions (8.4 times that of commercial Pt/C). This approach is also successfully applied to the synthesize of Au@Pd core/shell nanomaterials, thus demonstrating its generality.
Tailed‐Hoogsteen Triplex DNA Silver Nanoclusters Emit Red Fluorescence upon Target miRNA Sensing
Authors: Yadavalli Hari Chandana , Park Sooyeon , Kim Yeolhoe , Nagda Riddhi , Kim Tae‐Hwan , Han Min Kyun , Jung Il Lae , Bhang Yong Joo , Yang Won Ho , Dalgaard Louise Torp , Yang Seong Wook , Shah Pratik 
Published: November 2023

AbstractMicroRNAs (miRNAs) are small RNA molecules, typically 21‒22 nucleotides in size, which play a crucial role in regulating gene expression in most eukaryotes. Their significance in various biological processes and disease pathogenesis has led to considerable interest in their potential as biomarkers for diagnosis and therapeutic applications. In this study, a novel method for sensing target miRNAs using Tailed‐Hoogsteen triplex DNA‐encapsulated Silver Nanoclusters (DNA/AgNCs) is introduced. Upon hybridization of a miRNA with the tail, the Tailed‐Hoogsteen triplex DNA/AgNCs exhibit a pronounced red fluorescence, effectively turning on the signal. It is successfully demonstrated that this miRNA sensor not only recognized target miRNAs in total RNA extracted from cells but also visualized target miRNAs when introduced into live cells, highlighting the advantages of the turn‐on mechanism. Furthermore, through gel‐fluorescence assays and small‐angle X‐ray scattering (SAXS) analysis, the turn‐on mechanism is elucidated, revealing that the Tailed‐Hoogsteen triplex DNA/AgNCs undergo a structural transition from a monomer to a dimer upon sensing the target miRNA. Overall, the findings suggest that Tailed‐Hoogsteen triplex DNA/AgNCs hold great promise as practical sensors for small RNAs in both in vitro and cell imaging applications.
Design Strategy for Improving Detection Sensitivity in a Bromoplumbate Photochromic Semiconductor
Authors: Qin Qiu‐Pei , Lu Jian , Sun Cai , Wang Ming‐Sheng , Guo Guo‐Cong 
Published: November 2023

AbstractReducing the dark current of photodetectors is an important strategy for enhancing the detection sensitivity, but hampered by the manufacturing cost due to the need for controlling the complex material composition and processing intricate interface. This study reports a new single‐component photochromic semiconductor, [(HDMA)4(Pb3Br10)(PhSQ)2]n (1, HDMA = dimethylamine cation, PhSQ = 1‐(4‐sulfophenyl)−4,4’‐bipyridinium), by introducing a redox‐active monosubstituted viologen zwitterion into inorganic semiconducting skeleton. It features yellow to green coloration after UV irradiation with the sharply dropping intrinsic conductivity of 14.6‐fold, and the photodetection detection sensitivity gain successfully doubles. The reason of decreasing conductivity originates from the increasing the band gap of the inorganic semiconducting component and formation of Frenkel excitons with strong Coulomb interactions, thereby decreasing the concentration of thermally excited intrinsic carriers.