bluuebunny/crossref_metadata_2025_split huggingface dataset:
Knocking the Stability of Solar Cells with Fluorescent Protein Donors upon Rationalizing Design, Integration, and Mechanism
Authors: Chowdhury Sanchari , Nieddu Mattia , Patrian Marta , Gutiérrez‐Armayor David , Cavinato Luca M. , Fuenzalida‐Werner Juan Pablo , Lleó Miquel García , Ligi Simone , Costa Rubén D. 
Published: January 2024

AbstractThough photon‐induced electron donor features of fluorescent proteins (FPs) in solution suggest them as excellent photosensitizers, their poor stability upon device fabrication/operation is the today's frontier. This relates to their immediate denaturation in water‐free/less environments: inorganic/organic device interfaces and/or organic solvent surroundings. This study provides a fresh solution with a family of hybrid FPs, in which the peripheral carboxylic groups of archetypal FPs ‐superfolder green fluorescent protein (sfGFP) and mCherry‐ are transformed into alkoxysilane groups, enabling a straightforward integration with surprising stabilities over months in devices – arbitrary n/p‐type semiconducting metal oxide/FP/organic‐solvent electrolyte interfaces – attributed to the formation of an ion‐silica shell around the FP. This further allowed to understand the charge injection mechanism applying steady‐state/time‐resolved spectroscopy on different FP‐variants with key single‐point aromatic amino acid mutations at the chromophore nearest, revealing the electron‐donor hopping pathway via the initial loop of the strand β7. Finally, devices with state‐of‐the‐art solar‐to‐energy conversion efficiencies that are stable >2,000 h under operation nicely outperform the prior‐art stability of a few seconds/minutes in FP‐based solar cells. Hence, this work solves the integration/stability issues which blocking the application of FP‐based sensitizer, as well provides a solid understanding of their photo‐induced electron transfer mechanism.
Allogeneic “Zombie Cell” as Off‐The‐Shelf Vaccine for Postsurgical Cancer Immunotherapy
Authors: Li Bo , Zhang Ping , Li Junlin , Zhou Rui , Zhou Minglu , Liu Chendong , Liu Xi , Chen Liqiang , Li Lian 
Published: January 2024

AbstractAllogeneic tumor cell vaccines provide off‐the‐shelf convenience but lack patient specificity due to heterogeneity in tumor antigens. Here, allogeneic tumor cell corpses are converted into “zombie cells” capable of assimilating heterogeneous tumor by seizing cancer cells and spreading adjuvant infection. This causes pseudo‐oncolysis of tumors, transforming them into immunogenic targets for enhanced phagocytosis. It is shown that in postoperative tumor models, localized delivery of premade “zombie cells” through stepwise gelation in resection cavity consolidates tumor surgery. Compared to analogous vaccines lacking “seizing” or “assimilating” capability, “zombie cell” platform effectively mobilizes T cell response against residual tumors, and establishes immunological memory against tumor re‐challenge, showing less susceptibility to immune evasion. Despite using allogeneic sources, “zombie cell” platform functions as generalizable framework to produce long‐term antitumor immunity in different tumor models, showing comparable effect to autologous vaccine. Together, with the potential of off‐the‐shelf availability and personalized relevance to heterogenous tumor antigens, this study suggests an alternative strategy for timely therapy after tumor surgery.
Cloud‐Integrated Smart Nanomembrane Wearables for Remote Wireless Continuous Health Monitoring of Postpartum Women
Authors: Matthews Jared , Soltis Ira , Villegas‐Downs Michelle , Peters Tara A. , Fink Anne M. , Kim Jihoon , Zhou Lauren , Romero Lissette , McFarlin Barbara L. , Yeo Woon‐Hong 
Published: January 2024

AbstractNoncommunicable diseases (NCD), such as obesity, diabetes, and cardiovascular disease, are defining healthcare challenges of the 21st century. Medical infrastructure, which for decades sought to reduce the incidence and severity of communicable diseases, has proven insufficient in meeting the intensive, long‐term monitoring needs of many NCD disease patient groups. In addition, existing portable devices with rigid electronics are still limited in clinical use due to unreliable data, limited functionality, and lack of continuous measurement ability. Here, a wearable system for at‐home cardiovascular monitoring of postpartum women—a group with urgently unmet NCD needs in the United States—using a cloud‐integrated soft sternal device with conformal nanomembrane sensors is introduced. A supporting mobile application provides device data to a custom cloud architecture for real‐time waveform analytics, including medical device‐grade blood pressure prediction via deep learning, and shares the results with both patient and clinician to complete a robust and highly scalable remote monitoring ecosystem. Validated in a month‐long clinical study with 20 postpartum Black women, the system demonstrates its ability to remotely monitor existing disease progression, stratify patient risk, and augment clinical decision‐making by informing interventions for groups whose healthcare needs otherwise remain unmet in standard clinical practice.
Catalyzing Battery Materials Research via Lab‐Made, Sub‐Ampere‐Hour‐Scale Pouch Cells, and Long‐Term Electrochemical Monitoring by a Reparable Reference Electrode
Authors: Wang Yong , Li Zhiyuan , Li Xiaoqiao , Ma Zi‐Feng , Li Linsen 
Published: January 2024

AbstractBattery materials research is of crucial importance to the development of next‐generation batteries. However, the transition from lab‐scale studies, typically in gram quantities, to industrially relevant ones (i.e., kilogram scale) has been holding back by challenges in scale‐up synthesis and a lack of reliable approaches to verify the electrochemical performance of the lab‐made materials. Here the design and assembly procedures of sub‐Ah‐scale pouch cells that provide validations of several lab‐made Li‐ion and Na‐ion cathode materials available in a limited quantity (<5 g) are reported. These lab‐made pouch cells show superior cycle stability and consistency over the widely used coin cells, exemplified by multiple Ni‐rich layered oxide‐graphite full batteries retaining 84.29 ± 0.16% of the initial capacities over 1000 cycles. A four‐electrode pouch cell with a reparable reference electrode is further designed to monitor impedance growth and Li plating during long‐term electrochemical tests. It can be further integrated with in situ ultrasonic imaging to enable multi‐modal studies. This work provides a powerful platform to evaluate and boost the technology readiness levels of laboratory‐discovered battery materials.
Ligand‐engineered Zr‐MOF membranes with fast water transport channels for alcohol–water separation
Authors: Mo Binyu , Jin Yuanhang , Zhou Guangyuan , Liu Guozhen , Chen Cailing , Liu Zhengkun , Liu Gongping , Jin Wanqin 
Published: January 2024

AbstractMetal–organic framework (MOF) membranes with rich functionality and a tunable pore system are promising for molecular separation. However, an inadequate pore microenvironment and low water stability may hamper the extension of their use in gas separation to liquid separation (e.g., organic solvent dehydration). In this study, we report a high‐valence Zr‐MOF membrane with high stability and tunable pore microenvironment, prepared using a mixed‐ligand strategy based on fumarate (fum) and 2‐methylfumarate (mes) ligands for the pervaporation dehydration of alcohols. The introduction of a methyl group in the ligand side chain narrowed the aperture size while balancing the hydrophilicity, thus facilitating the fast and selective permeation of water over alcohol molecules. The resulting mes/fum‐Zr‐MOF membrane with a mes content of 30% displayed excellent butanol/water separation performance with total flux of 5226 g−1·m−2·h−1, separation factor of 1281, and water content of 99.3% in the permeate, transcending the upper‐bound of state‐of‐the‐art MOF and polymer membranes, thereby exhibiting immense potential for alcohols dehydration.
Periodontitis and brain magnetic resonance imaging markers of Alzheimer's disease and cognitive aging
Authors: Rubinstein Tom , Brickman Adam M. , Cheng Bin , Burkett Sandra , Park Heekuk , Annavajhala Medini K. , Uhlemann Anne‐Catrin , Andrews Howard , Gutierrez Jose , Paster Bruce J. , Noble James M. , Papapanou Panos N. 
Published: January 2024

AbstractINTRODUCTIONWe examined the association of clinical, microbiological, and host response features of periodontitis with MRI markers of atrophy/cerebrovascular disease in the Washington Heights Inwood Columbia Aging Project (WHICAP) Ancillary Study of Oral Health.METHODSWe analyzed 468 participants with clinical periodontal data, microbial plaque and serum samples, and brain MRIs. We tested the association of periodontitis features with MRI features, after adjusting for multiple risk factors for Alzheimer's disease/Alzheimer's disease‐related dementia (AD/ADRD).RESULTSIn fully adjusted models, having more teeth was associated with lower odds for infarcts, lower white matter hyperintensity (WMH) volume, higher entorhinal cortex volume, and higher cortical thickness. Higher extent of periodontitis was associated with lower entorhinal cortex volume and lower cortical thickness. Differential associations emerged between colonization by specific bacteria/serum antibacterial IgG responses and MRI outcomes.DISCUSSIONIn an elderly cohort, clinical, microbiological, and serological features of periodontitis were associated with MRI findings related to ADRD risk. Further investigation of causal associations is warranted.
Biomarkers of Alzheimer's disease and neurodegeneration in dried blood spots—A new collection method for remote settings
Authors: Huber Hanna , Blennow Kaj , Zetterberg Henrik , Boada Mercé , Jeromin Andreas , Weninger Haley , Nuñez‐Llaves Raul , Aguilera Núria , Ramis Maribel , Simrén Joel , Nilsson Johanna , Lantero‐Rodriguez Juan , Orellana Adelina , García‐Gutiérrez Fernando , Morató Xavier , Ashton Nicholas J. , Montoliu‐Gaya Laia 
Published: January 2024

AbstractBACKGROUNDWe aimed to evaluate the precision of Alzheimer's disease (AD) and neurodegeneration biomarker measurements from venous dried plasma spots (DPSvenous) for the diagnosis and monitoring of neurodegenerative diseases in remote settings.METHODSIn a discovery (n = 154) and a validation cohort (n = 115), glial fibrillary acidic protein (GFAP); neurofilament light (NfL); amyloid beta (Aβ) 40, Aβ42; and phosphorylated tau (p‐tau181 and p‐tau217) were measured in paired DPSvenous and ethylenediaminetetraacetic acid plasma samples with single‐molecule array. In the validation cohort, a subset of participants (n = 99) had cerebrospinal fluid (CSF) biomarkers.RESULTSAll DPSvenous and plasma analytes correlated significantly, except for Aβ42. In the validation cohort, DPSvenous GFAP, NfL, p‐tau181, and p‐tau217 differed between CSF Aβ‐positive and ‐negative individuals and were associated with worsening cognition.DISCUSSIONOur data suggest that measuring blood biomarkers related to AD pathology and neurodegeneration from DPSvenous extends the utility of blood‐based biomarkers to remote settings with simplified sampling conditions, storage, and logistics.Highlights
A wide array of biomarkers related to Alzheimer's disease (AD) and neurodegeneration were detectable in dried plasma spots (DPSvenous).
DPSvenous biomarkers correlated with standard procedures and cognitive status.
DPSvenous biomarkers had a good diagnostic accuracy discriminating amyloid status.
Our findings show the potential interchangeability of DPSvenous and plasma sampling.
DPSvenous may facilitate remote and temperature‐independent sampling for AD biomarker measurement.
Innovative tools for blood biomarker sampling may help recognizing the earliest changes of AD.
Dual‐Function Microwave Devices Based on Metamaterials
Authors: Pan Ze‐Yu , Wu Hai‐Bin , Lv Bo 
Published: January 2024

AbstractMicrowave detectors play a crucial role in modern technological applications, but traditional detectors suffer from limited functionality, limited detection accuracy, and difficulties in large‐scale deployment. This study proposes a dual‐function microwave detector based on metamaterials, capable of simultaneously measuring microwave power and polarization angle. The detector consists of a metal disc with 12 concave grooves, a dielectric layer, a metal reflector, and a resistive network. The designed detector achieves efficient absorption of 93.54% of microwave energy, with 75.4% dissipated in the resistive component and converted into heat. By detecting the temperature using a thermocouple thermometer, the incoming wave power can be determined, and by discriminating between different resistive temperatures, the polarization angle of the incoming wave can be identified. Simulation and experimental results demonstrate the outstanding detection efficiency and stability of this detector. It exhibits a linear response to different incident power densities and polarization angles, showing potential application value in the field of microwave wireless power transmission.
Enhanced antistatic and solvent resistant polycarbonate blends: Fabrication and characterization
Authors: Wu Fang , Pu Zejun , Yu DaYang , Zheng Pan , Zhu Rongli , Wang Xu , Yue Mengjie , Zhong Jiachun 
Published: January 2024

AbstractThis study presents the development of advanced antistatic and solvent resistant polycarbonate blends by incorporating antistatic agents (AAs) into bisphenol A‐type polycarbonate (PBPA) and polycarbonate‐polysiloxane copolymer (P‐Si). A straightforward one‐step melt blending was employed to fabricate PBPA/P‐Si/AA blends. Comprehensive characterization methods, including Fourier‐transform infrared spectroscopy (FT‐IR), optical microscope, thermogravimetric analysis (TGA), differential scanning calorimetry (DSC), and both tensile and impact tests were deployed to study the structure, morphology, thermal, and mechanical behaviors of the synthesized blends. The results demonstrated effective mixing of PBPA and P‐Si. The Tg of PBPA/P‐Si/AA blends is decreased relative to PBPA, because the chain flexibility of the blends will be increased after adding AA, which is reflected in the impact strength and elongation at break of PBPA/P‐Si/AA blends. On the other hand, the thermal stability of PBPA/P‐Si/AA is reduced relative to PBPA. The most significant result is that the resistance of the blends to ethyl acetate is enhanced. This is because the addition of P‐Si to the matrix introduces a high bonding energy SiO bond, which makes PHBPA/P‐Si less prone to detachment and cracking and swelling when exposed to ethyl acetate. While improving the solvent resistance, the blends also have excellent antistatic property, only the concentration of AA is increased to 6 wt.%, and the surface resistance of PBPA/P‐Si/AA is reduced from 106 GΩ to only 1 GΩ. This dramatic decrease is a result of the widespread distribution of the positive charge of the ammonium ion throughout the material, promoting the formation of a continuous conductive network within the matrix and thereby enhancing conductivity. In conclusion, this study offers valuable insights into improving the solvent resistance and antistatic characteristics of polycarbonate blends.
An ambient‐temperature superionic conductive, electrochemically stable, plastic cross‐linked polymer electrolyte for lithium metal battery
Authors: Wu Xiao , Zhang Yafei , Peng Shunjin 
Published: January 2024

AbstractA plastic cross‐linked polymer is prepared using acrylonitrile as a monomer and poly(ethylene glycol diacrylate) as a linking agent. A phase diagram‐guide rational design is introduced to fabricate the polymer composite electrolyte in the case of succinonitrile complexed with lithium bis‐trifluoromethanesulfonimide. The plastic cross‐linked polymer‐based electrolyte films with ambient‐temperature superionic conductivity (2.33 mS cm−1) and a wide electrochemical window (0–5.6 V vs. Li/Li+) have been demonstrated. The charging and discharging experiments of the plastic polymer composite electrolyte‐based lithium batteries show that the plastic polymer electrolyte can cycle normally and safely at a current density of 0.5 mA cm−2. These batteries exhibit excellent average coulombic efficiency of 98.5% in the first 150 cycles. The initial capacity at 25°C is 127.5 mAh g−1 (0.2 C), which is close to the value achieved by liquid‐electrolyte‐based cells under similar conditions. The capacity retention is 91% after 150 cycles.
Prevalence of bias against neurodivergence‐related terms in artificial intelligence language models
Authors: Brandsen Sam , Chandrasekhar Tara , Franz Lauren , Grapel Jordan , Dawson Geraldine , Carlson David 
Published: January 2024

AbstractGiven the increasing role of artificial intelligence (AI) in many decision‐making processes, we investigate the presence of AI bias towards terms related to a range of neurodivergent conditions, including autism, ADHD, schizophrenia, and obsessive‐compulsive disorder (OCD). We use 11 different language model encoders to test the degree to which words related to neurodiversity are associated with groups of words related to danger, disease, badness, and other negative concepts. For each group of words tested, we report the mean strength of association (Word Embedding Association Test [WEAT] score) averaged over all encoders and find generally high levels of bias. Additionally, we show that bias occurs even when testing words associated with autistic or neurodivergent strengths. For example, embedders had a negative average association between words related to autism and words related to honesty, despite honesty being considered a common strength of autistic individuals. Finally, we introduce a sentence similarity ratio test and demonstrate that many sentences describing types of disabilities, for example, “I have autism” or “I have epilepsy,” have even stronger negative associations than control sentences such as “I am a bank robber.”
Isotope Effects in a Li−S Battery: A New Concept
Authors: Li Xue‐Ting , Zhu Yu‐Hui , Tan Shuang‐Jie , Xin Sen 
Published: January 2024

AbstractLithium‐sulfur battery represents an innovative technology for the next generation electrochemical energy storage, and insight into the fundamentals about its electrochemistry is a key to improved battery storage performance. With years of striving efforts, the interpretation of Li−S reaction mechanism has been extended down to a molecular level. Based on our recent work, we propose to re‐examine the Li−S electrochemistry at a (sub)atomic level. Both Li anode and S cathode are made up of mixtures of stable isotopes. Provided with almost the same nucleus structure yet different neutron numbers (and atomic mass), these isotopes could affect the thermodynamic and kinetic parameters of a chemical reaction, and energy storage capability of a Li−S battery. At the cathode, 34S forms stronger S−S bonds and shows higher tendency to react with Li than 32S, so that it helps to improve cathode reaction kinetics. High‐order polysulfide anions based on 34S show more sluggish migration in the ether electrolyte than the 32S‐based counterparts, which accounts for improved cycling stability of battery. Based on the electrochemical isotope effects of S, a conceptual technology for separating isotopes from natural chalcogen elements was introduced and shows a higher separation factor than the conventional methods.
Essential Oils from the Genus Piper Promote Antinociception by Modulating TRP Channels and Anti‐Inflammatory Effects in Adult Zebrafish
Authors: Pereira Wandresa Francelino , Everson da Silva Luiz , do Amaral Wanderlei , Andrade Rebelo Ricardo , Quefi Blasco , Wlisses da Silva Antonio , Silva Marinho Emmanuel , Borges Leal Antonio Linkoln Alves , Mesquita Cajazeiras Francisco Ferdinando , Amâncio Ferreira Maria Kueirislene , Bezerra Maciel Jéssica , Ribeiro Liberato Hortência , Guedes Jesyka Macêdo , Silva Alencar de Menezes Jane Eire , Teixeira Alexandre Magno Rodrigues , Silva dos Santosa Helcio 
Published: January 2024

AbstractThe Piper genus, known for its pharmacological potential, comprises 2,263 species primarily found in tropical regions. Despite recent advancements in pain therapies, the demand for more effective and well‐tolerated analgesics and anti‐inflammatories, particularly for chronic pain, remains. This study assessed the effects of essential oils from Piper caldense, Piper mosenii, and Piper mikanianum on nociceptive behavior induced by formalin and capsaicin, as well as their anti‐inflammatory impact induced by carrageenan, using adult zebrafish models. Results indicated non‐toxic essential oils with antinociceptive properties in both neurogenic and inflammatory phases of formalin‐induced nociception through interaction with the TRPA1 receptor. Additionally, P. mosenii essential oil also blocked the nociceptive effect of capsaicin, a TRPV1 receptor agonist. Furthermore, essential oils from P. caldense and P. mikanianum exhibited significant anti‐inflammatory effects by reducing carrageenan‐induced abdominal edema. These findings highlight the pharmacological potential of Piper's essential oils as antinociceptive and anti‐inflammatory agents.
Multidisciplinary approach for acute MI complicated by ventricular tachycardia, stent thrombosis, and multi‐organ failure: A case report
Authors: Dutta Ujjwal P. , Bhatt Jugal Hiren , Nagori Irfan , Kagathara Nency , Zalavadiya Rushit , Sapkota Dilip 
Published: January 2024

Key Clinical MessageThe case highlights the imperative requirement for multidisciplinary action in handling a myocardial infarction case, complicated by rare and severe events like ventricular tachycardia, stent thrombosis, hypoxic brain injury, and multi‐organ failure.AbstractThis article presents a case of a 53‐year‐old male, who presented with myocardial infarction that was managed by percutaneous coronary intervention and stent placement. However, it progressed to multiple complications in sequence (ventricular tachycardia, stent thrombosis, hypoxic brain injury, and multi‐organ failure). Hopefully, the condition of the patient improved after 2 months from GSC‐4 to GCS‐9 by a multidisciplinary approach and was discharged for home‐based treatment.
Atypical anterior wall fracture extending to anterior inferior iliac spine with preservation of pelvic brim: A case report and literature review
Authors: Zandi Reza , Talebi Shahin , Ehsani Akbar , Bazgir Narges 
Published: January 2024

Key Clinical MessageAnterior acetabular wall fractures that extend into the anterior inferior iliac spine are more likely to be unstable, and more likely to require surgical fixation.AbstractConventional acetabular anterior wall fractures originate below the anterior inferior iliac spine (AIIS) level and involve the pelvic brim. Since surgical treatment is preserved for instability and hip incongruency, atypical variation of this fracture usually jeopardizes hip stability. We report on a 33‐year‐old case of an acetabular anterior wall fracture extending to the anterior inferior iliac spine. He was prepared for the stress test and hip stability checked, that was unstable in extension and external rotation. The joint was exposed with the Smith–Peterson approach. Hip congruency was restored, and the AIIS fragment was stabilized by open reduction. Acetabular anterior wall fracture involving AIIS with preservation of pelvic brim is a rare equivalent of anterior wall fracture that jeopardizes hip stability and should be managed surgically. Anterior approaches are preferred in order to visualize the joint.