bluuebunny/crossref_metadata_2025_split huggingface dataset:
Long‐term safety and efficacy outcomes of valoctocogene roxaparvovec gene transfer up to 6 years post‐treatment
Authors: Symington Emily , Rangarajan Savita , Lester Will , Madan Bella , Pierce Glenn F. , Raheja Priyanka , Robinson Tara M. , Osmond Dane , Russell Chris B. , Vettermann Christian , Agarwal Suresh K. , Li Mingjin , Wong Wing Yen , Laffan Michael 
Published: February 2024

AbstractIntroductionValoctocogene roxaparvovec uses an adeno‐associated virus serotype 5 (AAV5) vector to transfer a factor VIII (FVIII) coding sequence to individuals with severe haemophilia A, providing bleeding protection.AimTo assess safety and efficacy of valoctocogene roxaparvovec 5‒6 years post‐treatment.MethodsIn a phase 1/2 trial, adult male participants with severe haemophilia A (FVIII ≤1 IU/dL) without FVIII inhibitors or anti‐AAV5 antibodies received valoctocogene roxaparvovec and were followed for 6 (6 × 1013 vg/kg; n = 7) and 5 (4 × 1013 vg/kg; n = 6) years. Safety, including investigation of potential associations between a malignancy and gene therapy, and efficacy are reported.ResultsNo new treatment‐related safety signals emerged. During year 6, a participant in the 6 × 1013 vg/kg cohort was diagnosed with grade 2 parotid gland acinar cell carcinoma; definitive treatment was uncomplicated parotidectomy with lymph node dissection. Target enrichment sequencing of tumour and adjacent healthy tissue revealed low vector integration (8.25 × 10−5 per diploid cell). Integrations were not elevated in tumour samples, no insertions appeared to drive tumorigenesis, and no clonal expansion of integration‐containing cells occurred. During all follow‐ups, >90% decreases from baseline in annualised treated bleeds and FVIII infusion rates were maintained. At the end of years 6 and 5, mean FVIII activity (chromogenic assay) was 9.8 IU/dL (median, 5.6 IU/dL) and 7.6 IU/dL (median, 7.1 IU/dL) for the 6 × 1013 and 4 × 1013 vg/kg cohorts, respectively, representing proportionally smaller year‐over‐year declines than earlier timepoints.ConclusionsValoctocogene roxaparvovec safety and efficacy profiles remain largely unchanged; genomic investigations showed no association with a parotid tumour.
Knowledge gaps in health‐related quality of life research performed in children with bleeding disorders – A scoping review
Authors: Huisman Elise J. , Mussert Caroline , Bai Guannan , Raat Hein , Cnossen Marjon H. 
Published: February 2024

AbstractIntroductionBleeding disorders (BDs) may influence health‐related quality of life (HRQoL) in children and caregivers. Measuring HRQoL gives insight into domains requiring support and provides an opportunity to evaluate the effects of novel therapies.AimTo gain insight in the current body of literature on HRQoL in children with BDs in order to identify knowledge gaps for research and further development of this field.MethodsScoping review.ResultsWe included 53 articles, describing studies mainly performed in Europe and North–America (60.4%) and mostly within the last ten years. Only 32% studies included children <4 years. Almost all studies (47/53, 88.7%) were performed in boys with haemophilia, pooling haemophilia A and B (n = 21) and different disease severities (n = 20). Thirteen different generic and five disease‐specific HRQoL‐questionnaires were applied; all questionnaires were validated for haemophilia specifically. Six (11,3%) combined generic and disease‐specific questionnaires. Self‐reports were most frequently applied (40/53, 75.5%), sometimes combined with proxy and/or parent‐reports (17/53, 32.1%). Eleven studies used a reference group (20.8%). Statistical analyses mostly consisted of mean and SD (77.4%).ConclusionHRQoL‐research is mainly performed in school‐aged boys with haemophilia, treated in developed countries. Pitfalls encountered are the pooling of various BDs, subtypes and severities, as well as the application of multiple generic questionnaires prohibiting comparison of results. More attention is needed for broader study populations including other BDs, young children, feminine bleeding issues and platelet disorders, as well as the use of HRQoL as an effect‐measurement tool for medical interventions, and more thorough statistical analysis.
Drivers of compositional turnover in narrow‐ranged and widespread dragonflies and damselflies in Africa
Authors: Basel Ashleigh M. , Simaika John P. , Samways Michael J. , Midgley Guy F. , Latombe Guillaume , MacFadyen Sandra , Hui Cang 
Published: February 2024

Abstract
We aim to explore what processes dominate community assembly of dragonflies (Odonata: Anisoptera) and damselflies (Odonata: Zygoptera) by differentiating the environmental and geographical drivers behind compositional turnover of narrow‐ranged versus widespread species. In this way, we further aim to describe patterns of species incidence and compositional turnover to expand upon the body of knowledge related to understanding biodiversity patterns and processes.
We explored species turnover of dragonflies and damselflies separately, using zeta diversity to measure compositional turnover among multiple assemblages.
Narrow‐ranged and widespread species within each suborder showed similar drivers. Specifically, both narrow‐ranged and widespread dragonflies show rapid turnover with small shifts in annual mean temperature, temperature seasonality and annual precipitation, whereas for damselflies, the major driver for turnover is distance between sites followed by climatic variables. Our results therefore show that odonate turnover is largely driven by climate, although the limited dispersal capabilities of damselflies also influences community assembly.
Climate change could cause major changes in composition of odonates, presenting a challenge for conservation planning in Africa as species assemblages that were previously conserved may no longer be protected if their ranges shift outside protected areas. For damselflies, adaptation is a major concern, and with their limited dispersal capabilities and climate sensitivity, they may not be able to migrate effectively in response to changing climate conditions. The underlying assembly processes do not differ considerably for narrow‐ranged and widespread species within each suborder, suggesting that conservation planning tailored to each suborder may be sufficient in Africa.
Final irrigation with bioglass solution in regenerative endodontic procedure induces tissue formation inside the root canals, collagen maturation, proliferation cell and presence of osteocalcin
Authors: de Paula Kiani dos Santos , dos Reis‐Prado Alexandre Henrique , de Jesus Witalo Pereira , Goto Juliana , de Arantes Lara Cancella , Verçosa Marina , Cintra Luciano Tavares Angelo , Ervolino Edilson , Szawka Raphael Escorsim , Crovace Murilo Camuri , de Mesquita Ricardo Alves , Benetti Francine 
Published: February 2024

AbstractAimTo evaluate the influence of an experimental solution of cobalt‐doped F18 bioactive glass (F18Co) on tissue repair following regenerative endodontic procedure (REP) in rat molars.MethodologyThe F18Co solution was prepared at a ratio of 1:5 F18Co powder to distilled water. The right or left upper first molars of 12 Wistar rats were used, where the pulps were exposed, removed, and irrigated with 2.5% sodium hypochlorite (NaOCl), followed by 17% ethylenediaminetetraacetic acid (EDTA) (5 min each). Subsequently, the molars were divided into two groups (n = 6): REP‐SS and REP‐F18Co, where they received a final irrigation (5 min) with saline solution (SS) or F18Co solution, respectively. Then, intracanal bleeding was induced, and the tooth was sealed. Untreated molars were used as controls (n = 3). At 21 days, the rats were euthanized, and the specimens were processed for analysis of mineralized tissue and soft tissue formation inside the root canal using haematoxylin‐eosin. The presence and maturation of collagen were evaluated by Masson's trichrome and picrosirius red staining. Immunolabelling analyses of proliferating cell nuclear antigen (PCNA) and osteocalcin (OCN) were performed. The data were submitted to the Mann–Whitney U‐test (p < .05).ResultsThere was a similar formation of mineralized tissue in thickness and length in REP‐SS and REP‐F18Co groups (p > .05). Regarding the presence of newly formed soft tissue, most specimens of the REP‐F18Co had tissue formation up to the cervical third of the canal, whilst the REP‐SS specimens showed formation up to the middle third (p < .05), and there was higher maturation of collagen in REP‐F18Co (p < .05). The number of PCNA‐positive cells found in the apical third of the root canal was significantly higher in the F18Co group, as well as the OCN immunolabelling, which was severe in most specimens of REP‐F18Co, and low in most specimens of REP‐SS.ConclusionThe final irrigation with F18Co bioactive glass solution in REP did not influence mineralized tissue formation but induced soft tissue formation inside the root canals, with higher collagen maturation, and an increase in PCNA‐positive cells and OCN immunolabelling.
Patterns and determinants of multidimensional poverty and welfare interventions: Towards evidence‐based poverty‐alleviation policies in Hong Kong
Authors: Peng Chenhong , Chang Qingsong , Wang Julia Shu‐Huah , Yeung Cheuk Yui , Yip Paul S. F. 
Published: February 2024

AbstractThis study examines the patterns and determinants of multidimensional poverty and related welfare interventions in Hong Kong. These patterns unveil which dimension or combinations of dimensions contribute the most to multidimensional poverty. These results are useful in informing poverty‐alleviation policies as they help to identify who should be targeted and which welfare transfer programme(s) should be enhanced. Data were drawn from the first wave (2015) of the Hong Kong Panel Survey for Poverty Alleviation (N = 1458). A latent‐class analysis revealed four types of multidimensional poverty: severely deprived, housing‐led poor, socially and status excluded and neighbourhood poor. A multinomial logistic regression was conducted and identified distinctive determinants of the four types of poverty. The groups that require paramount attention from policymakers are older adults over age 70, households with members with disabilities or chronic diseases and households with five or more members. The assessment of the coverage and intensity of cash and in‐kind transfers showed that the coverage of cash transfers for the severely deprived and housing transfers for the housing‐led poor was inadequate. The approach proposed in this study exemplifies ways to transform multidimensional poverty research into evidence‐based policymaking.
Acculturation of Chinese international students in the US: Does sojourner status really matter?
Authors: Zeng Liwen 
Published: February 2024

AbstractDrawing upon the conceptual framework of ‘the sojourner’ in Siu's (American Journal of Sociology 58, 1952 and 34) work, this study employed semi‐structured in‐depth interviews with 59 Chinese international students and visiting scholars to investigate how their plans to return to China might shape their acculturation experiences in the United States (US). Those interviewed expressed a range of plans, including an immediate return to China, a postponed return, an undecided return and a clear refusal to return. Except for Chinese visiting scholars who were determined sojourners, a majority of the students interviewed regularly negotiated and adjusted their decisions to return based on their experiences in the US. By further exploring the post‐migration experiences of those who expressed some intention to sojourn, this study identifies four types of sojourning mentality, including (1) exploratory, (2) pragmatic, (3) disillusioned and (4) detached. Each type was found to distinctively influence and interplay students' experiences with acculturation and acculturative stress.
Impact of the COVID‐19 pandemic on provision of interventional cardiology and cardiac surgery services in Australia: a review of Medicare claims data
Authors: Sritharan Hari P. , Bhat Aditya , Chia Justin , Allahwala Usaid K. , Bhindi Ravinay 
Published: February 2024

AbstractBackgroundThe coronavirus disease 2019 (COVID‐19) pandemic has significantly impacted healthcare service provision worldwide. There is limited information on changes in invasive cardiovascular services during the pandemic, particularly in Australia.AimWe sought to assess temporal trends on the use of interventional cardiology and cardiac surgery services before and following the COVID‐19 pandemic in Australia.MethodsMedicare Benefits Schedule items data from the Australian Government Services Australia on outpatient and private hospital interventional cardiology procedures (coronary angiogram, percutaneous coronary intervention and transcatheter aortic valve implantation) and cardiac surgery procedures (coronary artery bypass grafting [CABG] and surgical valve replacement, repair and annuloplasty) were analysed from March 2019 to 2021. This was superimposed on monthly COVID‐19 case data obtained from the Australian Department of Health and Aged Care epidemiology reports.ResultsA sustained reduction in CABG (−10.1%) and surgical valve intervention (−11.1%) was appreciated from March 2019–2020 to March 2020–2021, in the first year of the COVID‐19 pandemic. During this period, an overall increase (+25.9%) in the use of transcatheter aortic valve implantation was observed. Following the initial period of mandated isolation in March–April 2020, a reduction in coronary angiography (−29.1%) and percutaneous coronary intervention (−19.5%) was observed in comparison to March–April 2019; however, this was largely attenuated over time.ConclusionsThe COVID‐19 pandemic has resulted in reductions in the use of interventional cardiology and cardiac surgery services, with cardiac surgery most affected. However, an increase in uptake of transcatheter aortic valve implantation has been observed during the pandemic. This may have implications for future planning and resource allocation in the aftermath of the pandemic.
Ultrafast laser ablation of tungsten carbide: Quantification of threshold range and interpretation of feature transition
Authors: Zhang Xiong , Wang Chunjin , Cheung Benny C. F. , Mi Gaoyang , Wang Chunming 
Published: February 2024

AbstractTungsten carbide was manufactured by picosecond laser in this study. Shapes of the ablated craters evolved from parabolic‐like (less than 10 pulses) to Gaussian‐like (more than 500 pulses) as the pulse number increased. The shape changes were closely associated with the discontinuous diameter expansion of ablated crater. To explain these phenomena, two thresholds were identified: an upper threshold of 0.129 J/cm2 and a lower threshold of 0.099 J/cm2. When the laser energy exceeded the upper threshold, ablation occurred under the laser‐energy‐dominated mode. When the laser energy fell between the upper and lower thresholds, ablation occurred under the cumulative‐effect‐dominated mode. The transition of ablation mode contributed to the diameter expansion and shape change. In addition, elemental composition varied significantly at the ablated crater and heat‐affected zone (HAZ), which were related to the degrees of reactions that occurred at different distances from the laser. Finally, surface hardness decreased from base material (32.52 GPa) to edge of crater (11.59 GPa) due to the escape of unpaired interstitial C atoms from the grain boundaries.
Maternal history of Alzheimer's disease predisposes to altered serum cholesterol levels in adult offspring
Authors: Liang Yuehui , Deng Ming‐Gang , Jian Qinghong , Liu Mingwei , Fang Kui , Chen Shuai 
Published: February 2024

AbstractControversial findings regarding the association between serum cholesterol levels and Alzheimer's disease (AD) have been identified through observational studies. The genetic basis shared by both factors and the causality between them remain largely unknown. The objective of this study is to examine the causal impact of maternal history of AD on changes in serum cholesterol levels in adult offspring. By retrieving genetic variants from summary statistics of large‐scale genome‐wide association study of maternal history of AD (European‐based: Ncase = 27 696, Ncontrol = 260 980). The causal association between genetically predicted maternal history of AD and changes in serum cholesterol levels in adult offspring was examined using the two‐sample Mendelian randomization (MR) method. Causal impact estimates were calculated using single‐nucleotide polymorphisms in both univariable MR (UMR) and multivariable MR (MVMR) analyses. Additionally, other approaches, such as Cochran's Q test and leave‐one‐out variant analysis, were employed to correct for potential biases. The results of UMR presented that genetically predicted maternal history of AD was positively associated with hypercholesterolemia (OR = 1.014; 95% CI: 1.009–1.018; p < 0.001), total cholesterol (OR = 1.29; 95% CI: 1.134–1.466; p < 0.001) and low‐density lipoprotein (OR = 1.525; 95% CI: 1.272–1.828; p < 0.001) among adult offspring. Genetic predisposition for maternal history of AD to be negatively associated with high‐density lipoprotein (OR = 0.889; 95% CI: 0.861–0.917; p < 0.001). The MVMR analysis remained robust and significant after adjusting for diabetes and obesity in offspring. Sufficient evidence was provided in this study to support the putative causal impact of maternal history of AD on the change of serum cholesterol profile in adult offspring. In clinical practice, priority should be given to the detection and monitoring of cholesterol levels in individuals with a maternal history of AD, particularly in the early stages.image
Theorizing White heteropatriarchal supremacy, marriage fundamentalism, and the mechanisms that maintain family inequality
Authors: Letiecq Bethany L. 
Published: February 2024

AbstractIn this article, I draw upon critical feminist and intersectional frameworks to delineate an overarching orientation to structural oppression and unequal power relations that advantages White heteropatriarchal nuclear families (WHNFs) and marginalizes others as a function of family structure and relationship status. Specifically, I theorize that marriage fundamentalism, like structural racism, is a key structuring element of White heteropatriarchal supremacy. Marriage fundamentalism can be understood as an ideological and cultural phenomenon, where adherents espouse the superiority of the two‐parent married family. But it is also a hidden or unacknowledged structural mechanism of White heteropatriarchal family supremacy that is essential to the reproduction and maintenance of family inequality in the United States. Through several examples, I demonstrate how—since colonization—marriage fundamentalism has been instantiated through laws, policies, and practices to unduly advantage WHNFs while simultaneously marginalizing Black, Indigenous, immigrant, mother‐headed, and lesbian, gay, bisexual, transgender, queer/questioning (LGBTQ+) families, among others. I conclude with a call for family scientists to further interrogate how marriage fundamentalism reproduces family inequality in American family life and to work toward its dismantling. A deeper understanding of how these complex and often covert mechanisms of structural oppression operate in family life is needed to disrupt these mechanisms and advance family equality and justice.
Voice Work, Upward Influence during Change ‘When Time is of the Essence’
Authors: Jaser Zahira 
Published: February 2024

AbstractThis paper explores when and how middle managers (MMs) convey voice to the top during strategic change, when they do not have the time for lengthy persuasive upward influence tactics such as issue‐selling. I investigate this phenomenon through a 33‐month study of a risk management team in a large bank as it tried to overhaul its risk management systems and culture, after catastrophic money laundering scandals. I make three contributions. First, I complement the issue‐selling literature by theorizing voice work as the purposeful efforts made by middle and lower managers to pass challenges from the bottom to the top during change. These efforts are grouped into three sets of moves: relational, reflexive and skip level. Second, I contribute to the voice literature by explaining when MMs decide to speak up through relational moves (balancing and integrating) and how they shape their voice message through reflexive moves (preparing and refining). Lastly, I refine our understanding of skip level voice by defining skip level moves (overriding and reinforcing), introducing nuance into how lower managers’ voice can strengthen or destabilize MMs. Voice work ultimately enriches our processual understanding of voice as a dynamic phenomenon worked on by multiple layers of management. Theory is built by amalgamating literatures on voice and on MMs’ upward influence, and by analysing them through the sociological lens of work.
Phytocannabinoids and gingival inflammation: Preclinical findings and a placebo‐controlled double‐blind randomized clinical trial with cannabidiol
Authors: Jirasek Petr , Jusku Alexandr , Frankova Jana , Urbankova Marketa , Diabelko Daniel , Ruzicka Filip , Papouskova Barbora , Chytilova Karin , Vrba Jiri , Havlasek Jakub , Langova Katerina , Storch Jan , Voborna Iva , Simanek Vilim , Vacek Jan 
Published: February 2024

AbstractObjectiveThe aim of this study was to: (1) evaluate the anti‐inflammatory effects of cannabidiol (CBD) on primary cultures of human gingival fibroblasts (HGFs) and (2) to clinically monitor the effect of CBD in subjects with periodontitis.BackgroundThe use of phytocannabinoids is a new approach in the treatment of widely prevalent periodontal disease.Materials and MethodsCannabinoid receptors were analyzed by western blot and interleukin production detected using enzyme immunoassay. Activation of the Nrf2 pathway was studied via monitoring the mRNA level of heme oxygenase‐1. Antimicrobial effects were determined by standard microdilution and 16S rRNA screening. In the clinical part, a placebo‐control double‐blind randomized study was conducted (56 days) in three groups (n = 90) using dental gel without CBD (group A) and with 1% (w/w) CBD (group B) and corresponding toothpaste (group A – no CBD, group B – with CBD) for home use to maintain oral health. Group C used dental gel containing 1% chlorhexidine digluconate (active comparator) and toothpaste without CBD.ResultsHuman gingival fibroblasts were confirmed to express the cannabinoid receptor CB2. Lipopolysaccharide‐induced cells exhibited increased production of pro‐inflammatory IL‐6 and IL‐8, with deceasing levels upon exposure to CBD. CBD also exhibited antimicrobial activities against Porphyromonas gingivalis, with an MIC of 1.5 μg/mL. Activation of the Nrf2 pathway was also demonstrated. In the clinical part, statistically significant improvement was found for the gingival, gingival bleeding, and modified gingival indices between placebo group A and CBD group B after 56 days.ConclusionsCannabidiol reduced inflammation and the growth of selected periodontal pathogenic bacteria. The clinical trial demonstrated a statistically significant improvement after CBD application. No adverse effects of CBD were reported by patients or observed upon clinical examination during the study. The results are a promising basis for a more comprehensive investigation of the application of non‐psychotropic cannabinoids in dentistry.