bluuebunny/crossref_metadata_2025_split huggingface dataset:
Fluid Physiology Part 2: Regulation of Body Fluids and the Distribution of Infusion Fluids
Authors: Hahn Robert G. 
Published: November 2023

AbstractThe regulation of body fluids and infusion fluid distribution is a critical aspect of intensive care management. In this chapter, we explore the various control systems that maintain fluid balance in the body, including the kidneys, nervous system, and hormones. We also discuss the impact of disease and medical treatments on these control systems and the resulting fluid derangements, such as hypovolemia, volume depletion, and dehydration. The use of infusion fluids to distribute into the different body fluid spaces is analyzed, including the plasma, extracellular fluid, and total body water. Hemodynamic responses and signs of organ dysfunction are the main clinical guides for fluid management, while electrolyte disturbances induced by disease and medication are also discussed. Volume kinetic analysis is utilized to compare the efficacy of crystalloid and colloid solutions, and the limitations of body fluid volume measurements are also examined. This chapter provides essential insights for intensivists and other medical professionals involved in the management of critically ill patients.
Restrictions of Pfaffian systems for Feynman integrals
Authors: Chestnov Vsevolod , Matsubara-Heo Saiei J. , Munch Henrik J. , Takayama Nobuki 
Published: November 2023

Abstract
This work studies limits of Pfaffian systems, a class of first-order PDEs appearing in the Feynman integral calculus. Such limits appear naturally in the context of scattering amplitudes when there is a separation of scale in a given set of kinematic variables. We model these limits, which are often singular, via restrictions of $$ \mathcal{D} $$
D
-modules. We thereby develop two different restriction algorithms: one based on gauge transformations, and another relying on the Macaulay matrix. These algorithms output Pfaffian systems containing fewer variables and of smaller rank. We show that it is also possible to retain logarithmic corrections in the limiting variable. The algorithms are showcased in many examples involving Feynman integrals and hypergeometric functions coming from GKZ systems. This work serves as a continuation of [1].
Holographic entanglement from the UV to the IR
Authors: Dong Xi , Remmen Grant N. , Wang Diandian , Weng Wayne W. , Wu Chih-Hung 
Published: November 2023

Abstract
In AdS/CFT, observables on the boundary are invariant under renormalization group (RG) flow in the bulk. In this paper, we study holographic entanglement entropy under bulk RG flow and find that it is indeed invariant. We focus on tree-level RG flow, where massive fields in a UV theory are integrated out to give the IR theory. We explicitly show that in several simple examples, holographic entanglement entropy calculated in the UV theory agrees with that calculated in the IR theory. Moreover, we give an argument for this agreement to hold for general tree-level RG flow. Along the way, we generalize the replica method of calculating holographic entanglement entropy to bulk theories that include matter fields with nonzero spin.
Auswirkungen einer Pandemie auf Menschen mit Seltenen Erkrankungen und Empfehlungen zur Aufrechterhaltung von Versorgung und Teilhabe
Authors: Zybarth David , Brandt Maja , Mundlos Christine , Inhestern Laura 
Published: November 2023

Zusammenfassung
Hintergrund
Seltene Erkrankungen sind häufig durch komplexe Beschwerdebilder charakterisiert und erfordern in der Regel im Diagnose- und Versorgungsverlauf die Koordination multiprofessioneller Behandlungsteams. Im Zuge der COVID-19-Pandemie veränderten sich die medizinische Versorgung und der Lebensalltag von Menschen mit einer Seltenen Erkrankung bzw. den Eltern bei minderjährigen Patient:innen drastisch. Das Projekt RESILIENT-SE-PAN („Retrospektive Analyse der Versorgungssituation und des Lebensalltags von Menschen mit Seltenen Erkrankungen während einer Pandemie und Ableitung von Handlungsempfehlungen“) hatte auf Grundlage verschiedener Perspektiven das Ziel, die Situation von Menschen mit einer Seltenen Erkrankung während der Pandemie zu erfassen und Empfehlungen abzuleiten.

Methoden
Es wurden quantitative und qualitative Befragungen aus Perspektive der Betroffenen bzw. der Angehörigen bei minderjährigen Patient:innen (i. d. R. Elternteil) und aus Perspektive von Vertreter:innen der Patient:innenorganisationen sowie ein Workshop durchgeführt (Mixed-Methods-Studie).

Ergebnisse
Es zeigten sich Auswirkungen auf die Versorgung und auf den Lebensalltag sowie psychische Belastungen der Befragten. Darüber hinaus wurden COVID-19-spezifische Aspekte, Unterstützungsbedarf und auch positive Aspekte berichtet. Auf Basis der umfassenden Ergebnisse wurden insgesamt 21 Empfehlungen in den folgenden 7 Bereichen formuliert: medizinische Diagnostik und Versorgung der Seltenen Erkrankung; ergänzende Therapien, Hilfs- und Heilmittel; Zugang zu Informationen und Impfungen bzgl. COVID-19; psychosoziale Unterstützung; Alltagshilfen/Teilhabe; Patient:innenorganisationen und Sonstiges/übergeordnete Aspekte.

Diskussion
Die formulierten Empfehlungen geben für künftige Krisen oder Pandemien wichtige Impulse, um die Situation von Menschen mit einer Seltenen Erkrankung adäquat zu berücksichtigen und entsprechend den Bedarfen der Betroffenen zu handeln.
TCAF2 drives glioma cellular migratory/invasion properties through STAT3 signaling
Authors: Yun Debo , Liang Jianshen , Wang Xuya , Fan Jikang , Wang Xisen , Li Jiabo , Ren Xiao , Liu Jie , Ren Xiude , Zhang Hao , Shang Guanjie , Jin Wenzhe , Chen Lei , Li Tao , Zhang Chen , Yu Shengping , Yang Xuejun 
Published: November 2023

AbstractGlioma is an intracranial tumor characterized by high mortality and recurrence rates. In the present study, the association of TRPM8 channel-associated factor 2 (TCAF2) in glioma was investigated using bioinformatics, showing significant relationships with age, WHO grade, IDH, and 1p/19q status, as well as being an independent predictor of prognosis. Immunohistochemistry of a glioma sample microarray showed markedly increased TCAF2 expression in glioblastoma relative to lower-grade glioma, with elevated expression predominating in the tumor center. Raised TCAF2 levels promote glioma cell migratory/invasion properties through the epithelial-to-mesenchymal transition-like (EMT-like) process, shown by Transwell and scratch assays and western blotting. It was further found that the effects of TCAF2 were mediated by the activation of STAT3. These results suggest that TCAF2 promotes glioma cell migration and invasion, rendering it a potential drug target in glioma therapy.
Investigating Europa’s Habitability with the Europa Clipper
Authors: Vance Steven D. , Craft Kathleen L. , Shock Everett , Schmidt Britney E. , Lunine Jonathan , Hand Kevin P. , McKinnon William B. , Spiers Elizabeth M. , Chivers Chase , Lawrence Justin D. , Wolfenbarger Natalie , Leonard Erin J. , Robinson Kirtland J. , Styczinski Marshall J. , Persaud Divya M. , Steinbrügge Gregor , Zolotov Mikhail Y. , Quick Lynnae C. , Scully Jennifer E. C. , Becker Tracy M. , Howell Samuel M. , Clark Roger N. , Dombard Andrew J. , Glein Christopher R. , Mousis Olivier , Sephton Mark A. , Castillo-Rogez Julie , Nimmo Francis , McEwen Alfred S. , Gudipati Murthy S. , Jun Insoo , Jia Xianzhe , Postberg Frank , Soderlund Krista M. , Elder Catherine M. 
Published: November 2023

AbstractThe habitability of Europa is a property within a system, which is driven by a multitude of physical and chemical processes and is defined by many interdependent parameters, so that its full characterization requires collaborative investigation. To explore Europa as an integrated system to yield a complete picture of its habitability, the Europa Clipper mission has three primary science objectives: (1) characterize the ice shell and ocean including their heterogeneity, properties, and the nature of surface–ice–ocean exchange; (2) characterize Europa’s composition including any non-ice materials on the surface and in the atmosphere, and any carbon-containing compounds; and (3) characterize Europa’s geology including surface features and localities of high science interest. The mission will also address several cross-cutting science topics including the search for any current or recent activity in the form of thermal anomalies and plumes, performing geodetic and radiation measurements, and assessing high-resolution, co-located observations at select sites to provide reconnaissance for a potential future landed mission. Synthesizing the mission’s science measurements, as well as incorporating remote observations by Earth-based observatories, the James Webb Space Telescope, and other space-based resources, to constrain Europa’s habitability, is a complex task and is guided by the mission’s Habitability Assessment Board (HAB).
Entity alignment via graph neural networks: a component-level study
Authors: Shu Yanfeng , Zhang Ji , Huang Guangyan , Chi Chi-Hung , He Jing 
Published: November 2023

AbstractEntity alignment plays an essential role in the integration of knowledge graphs (KGs) as it seeks to identify entities that refer to the same real-world objects across different KGs. Recent research has primarily centred on embedding-based approaches. Among these approaches, there is a growing interest in graph neural networks (GNNs) due to their ability to capture complex relationships and incorporate node attributes within KGs. Despite the presence of several surveys in this area, they often lack comprehensive investigations specifically targeting GNN-based approaches. Moreover, they tend to evaluate overall performance without analysing the impact of individual components and methods. To bridge these gaps, this paper presents a framework for GNN-based entity alignment that captures the key characteristics of these approaches. We conduct a fine-grained analysis of individual components and assess their influences on alignment results. Our findings highlight specific module options that significantly affect the alignment outcomes. By carefully selecting suitable methods for combination, even basic GNN networks can achieve competitive alignment results.
A global and regional assessment of the timing of birth registration using DHS and MICS survey data
Authors: Adair Tim , Li Hang 
Published: November 2023

AbstractRegistration of birth within the first year of life is important to ensure children receive its full benefits and that fertility statistics derived from these data are informative for policy. This study provides an up-to-date global and regional assessment of the timing of birth registration by using all available birth registration data of children aged less than five years reported in Demographic and Health Surveys and Multiple Indicator Cluster Surveys from 2010 onwards. We calculated adjusted age-specific birth registration completeness by converting period age-specific completeness data into a hypothetical cohort. Timing of birth registration was analysed using ratios of adjusted age-specific completeness, with differentials by region, over time, and level of completeness assessed using bivariate and multivariate analyses. Almost 20% of registered births in countries with incomplete birth registration (less than 95%) were not registered until after 12 months, and this has not improved since 2010. In several countries this figure is greater than 50%, particularly in South Asia. There remains considerable scope to improve the timeliness of birth registration, particularly in countries where the overall level of completeness is lower. Strengthening and enforcing legislation for the mandatory registration of births before age 12 months and greater involvement of the health sector in registration processes are two ways which will improve birth registration timing.
Predicting academic success: machine learning analysis of student, parental, and school efforts
Authors: Jin Xin 
Published: November 2023

AbstractUnderstanding what predicts students’ educational outcomes is crucial to promoting quality education and implementing effective policies. This study proposes that the efforts of students, parents, and schools are interrelated and collectively contribute to determining academic achievements. Using data from the China Education Panel Survey conducted between 2013 and 2015, this study employs four widely used machine learning techniques, namely, Lasso, Random Forest, AdaBoost, and Support Vector Regression, which are effective for prediction tasks—to explore the predictive power of individual predictors and variable categories. The effort exerted by each group has varying impacts on academic exam results, with parents’ demanding requirements being the most significant individual predictor of academic performance; the category of school effort has a greater impact than parental and student effort when controlling for various social-origin-based characteristics; and significant gender differences among junior high students in China, with school effort exhibiting a greater impact on academic achievement for girls than for boys, and parental effort showing a greater impact for boys than for girls. This study advances the understanding of the role of effort as an independent factor in the learning process, theoretically and empirically. The findings have substantial implications for education policies aimed at enhancing school effort, emphasizing the need for gender-specific interventions to improve academic performance for all students.
Deciphering the roles of triiodothyronine (T3) and thyroid-stimulating hormone (TSH) on cardiac electrical remodeling in clinical and experimental hypothyroidism
Authors: Casis Oscar , Echeazarra Leire , Sáenz-Díez Beatriz , Gallego Mónica 
Published: November 2023

AbstractHypothyroidism is the most frequent endocrine pathology. Although clinical or overt hypothyroidism has been traditionally associated to low T3 / T4 and high thyrotropin (TSH) circulating levels, other forms exist such as subclinical hypothyroidism, characterized by normal blood T3 / T4 and high TSH. In its different forms is estimated to affect approximately 10% of the population, especially women, in a 5:1 ratio with respect to men. Among its consequences are alterations in cardiac electrical activity, especially in the repolarization phase, which is accompanied by an increased susceptibility to cardiac arrhythmias. Although these alterations have traditionally been attributed to thyroid hormone deficiency, recent studies, both clinical trials and experimental models, demonstrate a fundamental role of TSH in cardiac electrical remodeling. Thus, both metabolic thyroid hormones and TSH regulate cardiac ion channel expression in many and varied ways. This means that the different combinations of hormones that predominate in different types of hypothyroidism (overt, subclinic, primary, central) can generate different forms of cardiac electrical remodeling. These new findings are raising the relevant question of whether serum TSH reference ranges should be redefined.
Characterization of blaOXA-48-carrying plasmids and small non-AMR-coding plasmids collected from Ukrainian patients
Authors: van Almsick Vincent F. , Sobkowiak Annika , Scherff Natalie , Schuler Franziska , Mellmann Alexander , Schwierzeck Vera 
Published: November 2023

Abstract
Purpose
Carbapenemase-producing Enterobacterales (CPE) pose a serious threat for healthcare facilities worldwide, yet the mode of transmission is often unclear. Recently, we recorded an increase of blaOXA-48-harboring isolates at our hospital associated with patients with previous medical treatment in the Ukraine. We used long-read whole genome sequencing (lrWGS) to characterize these isolates including their plasmids.

Methods
Samples were collected as part of clinical routine diagnostic or screening of multi-drug resistance bacteria (MDRB). Antimicrobial susceptibility testing was performed and all MDRB (n = 10) were sequenced by lrWGS for genotyping, identification of antimicrobial resistance (AMR) genes, and characterization of plasmids.

Results
While routine analysis of core genome multilocus sequence typing (cgMLST) did not show any genetic similarities between isolates, we found an unexpected high similarity in the plasmid diversity of different Enterobacterales in patients with previous medical treatment in the Ukraine. This included an IncL/M plasmid carrying blaOXA-48 and additional small non-AMR-coding plasmids.

Conclusion
Our results show that lrWGS can be used in the routine setting to uncover similarities in plasmids and may give further information about potential epidemiologic associations. In the future, analysis of both AMR and non-AMR plasmids may provide an additional layer of information for molecular surveillance of CPE.
Acute kidney injury in multiple myeloma patients undergoing autologous hematopoietic stem cell transplant: a cohort study
Authors: Rodrigues Natacha , Costa Claudia , Branco Carolina , Martins Carlos , Lopes José António 
Published: November 2023

Abstract
Background
Autologous hematopoietic stem cell transplant plays an important role in multiple myeloma (MM) treatment. Increasing incidence of MM and growing awareness of acute kidney injury (AKI) as a complication of hematopoietic stem cell transplant results in the need to better understand AKI in these patients. We aimed to evaluate incidence, risk factors and 5-year prognostic impact of AKI in MM patients undergoing autologous hematopoietic stem cell transplant.

Methods
Retrospective cohort study. AKI was defined by the KDIGO classification using creatinine and urinary output criteria. We used survival analysis methods considering competing events for risk factors and disease-free survival, Cox proportional regression for overall survival and stepwise regression methods for multivariable models.

Results
We analyzed data regarding 143 patients. The cumulative incidence of AKI and moderate-to-severe AKI was 49.7% and 14.1%, respectively. Factors with independent impact on AKI were obesity (HR: 1.83, 95% CI 1.07–3.11; p = 0.026), Hematopoietic cell transplantation—specific comorbidity index (HCT-CI) ≥ 2 (HR: 1.85, 95% CI 1.08–3.17), chronic kidney disease (CKD) (HR: 2.06, 95% CI 1.05–4.04), amyloidosis (HR: 2.25, 95% CI 1.25–4.06), mucositis grade 3–4 (HR: 2.19, 95% CI 1.25–3.86) and exposure to nephrotoxic drugs (HR: 2.0856, 95% CI 1.04–4.19). Moderate-to-severe AKI had an impact (HR: 1.62, 95% CI 1.15–2.31) on 5-year overall survival.

Conclusion
Acute kidney injury affects almost half of MM patients undergoing autologous hematopoietic stem cell transplantation, and reduction in urinary output allows early diagnosis in almost a quarter of the patients. Obesity, HCT-CI ≥ 2, CKD, amyloidosis, mucositis grade 3–4 and exposure to nephrotoxic drugs are significant risk factors. Moderate-to-severe AKI is associated with lower 5-year overall survival.

Graphical abstract
Ready or Not
Authors: Morgan Rachel 
Published: November 2023

AbstractDebates about the best means of preparing archaeologists continue. This article reviews data from 674 archaeological job postings to assess in-demand archaeological knowledge, skills, and abilities. The needs assessment reveals American archaeology's demand for dynamic, highly skilled professionals capable of identifying, preserving, and protecting the past. The skills demanded in archaeology job postings are the skills necessary to not only succeed as an archaeologist in any sector but also meet the challenges faced by the discipline more generally.
Thermal management system design for a series hybrid-electric propulsion architecture
Authors: Potamiti M. , Gkoutzamanis V.G. , Kalfas A.I. 
Published: November 2023

AbstractThe current paper is focused on the conceptual design of a thermal management system with a liquid working medium for a commuter hybrid-electric aircraft, featuring a series propulsion configuration. Regarding the system’s architecture, parametric analyses are conducted, by altering the number of heat exchangers. To clarify, a centralised and a decentralised thermal management system architecture are examined. Furthermore, a computational model calculates the temperatures during the system’s operation and the required coolant mass flows to sufficiently cool all the compartments. Subsequently, the required heat exchanger surface is determined and the weight of each compartment that comprises the thermal management system can be calculated. It is worth noting, that the compartments’ cold plate weight is integrated. The results indicate that the decentralised configuration results in lower temperature fields for all components compared to the centralised configuration. However, the latter weighs 32.2% lower at 158.22kg while the decentralised configuration weighs 233.48kg.
Transition From Primary to Secondary School From the Perspectives of Students With Autism Spectrum Disorder and Concomitant Intellectual Giftedness
Authors: Minnie Carolyn Anne 
Published: November 2023

AbstractTransition from primary to secondary school is an often challenging milestone in the lives of all students. Although existing research provides insight into transition for students with autism spectrum disorder (ASD), research that considers transition from the perspective of students with ASD and concomitant intellectual giftedness (IG) appears scant. This paper contributes to narrowing this gap by providing insight into the experiences of 21 students with ASD and concomitant IG who had already transitioned to secondary school. Data gathered from focus group discussions revealed that this particular cohort of students experienced difficulties in gaining social acceptance by same-age peers and were unequipped to meet the expectations of secondary school teachers and an increased workload, which intensified their transition experience. These findings highlight that this cohort of students requires specific preparation and support to transition to secondary school, which was not occurring.
GENUS CURVES WITH BAD REDUCTION AT ONE ODD PRIME
Authors: DĄBROWSKI ANDRZEJ , SADEK MOHAMMAD 
Published: November 2023

AbstractThe problem of classifying elliptic curves over
$\mathbb Q$
with a given discriminant has received much attention. The analogous problem for genus
$2$
curves has only been tackled when the absolute discriminant is a power of
$2$
. In this article, we classify genus
$2$
curves C defined over
${\mathbb Q}$
with at least two rational Weierstrass points and whose absolute discriminant is an odd prime. In fact, we show that such a curve C must be isomorphic to a specialization of one of finitely many
$1$
-parameter families of genus
$2$
curves. In particular, we provide genus
$2$
analogues to Neumann–Setzer families of elliptic curves over the rationals.