bluuebunny/crossref_metadata_2025_split huggingface dataset:
Inhibition of miR-542-3p augments autophagy to promote diabetic corneal wound healing
Authors: Liao Danling , Wei Shijia , Hu Jianzhang 
Published: January 2024

Abstract
Background
Autophagy has recently been shown to be critical for protecting peripheral nerve regeneration. This study explored the impact of miR-542-3p on diabetic corneal nerve regeneration and epithelial healing through the regulation of autophagy.

Methods
A type 1 diabetes model was established in male mice through streptozotocin administration. Immunofluorescence staining of β-Tubulin III and sodium fluorescein staining were performed to observe corneal nerve fiber density and corneal epithelial healing, respectively. Western blotting, immunofluorescence and transmission electron microscopy were used to determine autophagy levels. Subconjunctival injection of RAPA and 3-MA altered autophagy levels; with them, we evaluated the role of autophagy in diabetic keratopathy. miRNA sequencing and bioinformatics analysis were performed to identify miRNA-mRNA networks with potential autophagy-regulating roles, and miR-542-3p was measured by quantitative real-time polymerase chain reaction (qRT-PCR). miR-542-3p antagomir was injected subconjunctivally to assess the role in diabetic corneal neuropathy.

Results
Our data suggest that autophagy is suppressed in the diabetic corneal nerve and that activation of autophagy promotes diabetic corneal wound healing. We identified a potential autophagy-regulating miRNA-mRNA network in the diabetic trigeminal ganglion, in which miR-542-3p expression was significantly upregulated. Inhibition of miR-542-3p significantly enhanced the level of autophagy in trigeminal ganglion by upregulating ATG4D expression, thereby accelerating diabetic corneal nerve regeneration and epithelial healing.

Conclusions
Dysregulated autophagy is an important contributor to delayed diabetic corneal injury healing. Inhibiting miR-542-3p promotes diabetic corneal nerve regeneration and epithelial healing through autophagy activation by ATG4D.
NCAPD2 is a favorable predictor of prognostic and immunotherapeutic biomarker for multiple cancer types including lung cancer
Authors: Feng Linyuan , Yang Yang , Lin Zhenhua , Cui Minghua , Jin Aihua , Cui Aili 
Published: January 2024

Abstract
Background
Non-SMC condensin I complex subunit D2 (NCAPD2) belongs to the chromosomal structural maintenance family. While the different contribution of NCAPD2 to chromosome in mitosis have been thoroughly investigated, much less is known about the expression of NCAPD2 in pan-cancer. Thus, we used a bioinformatics dataset to conduct a pan-cancer analysis of NCAPD2 to determine its regulatory role in tumors.

Methods
Multiple online databases were analyzed NCAPD2 gene expression, protein level, patient survival and functional enrichment in pan-cancer. Genetic alteration and tumor stemness of NCAPD2 were analyzed using cBioPortal and SangerBox. The GSCA and CellMiner were used to explore the relationship between NCAPD2 and drug sensitivity. The diagnostic value of prognosis was evaluated by ROC curve. Subsequently, the immune infiltration level and immune subtype of NCAPD2 in lung adenocarcinoma (LUAD) and lung squamous cell carcinoma (LUSC) were analyzed using TIMER1 and TISIDB.

Results
NCAPD2 gene expression was significantly higher in most cancers and associated with clinical stage and poor prognosis. Genomic heterogeneity of NCAPD2 promoted the occurrence and development of tumors. GO enrichment analysis suggested NCAPD2 might be involved in DNA repair and immune response. NCAPD2 was involved in immune infiltration of LUAD and LUSC. ROC curves showed that NCAPD2 has important prognosis diagnostic value in LUAD and LUSC. Moreover, NCAPD2 was drug sensitive to topotecan, which may be an optimize immunotherapy.

Conclusions
It was found that NCAPD2 was overexpressed in pan-cancers, which was associated with poor outcomes. Importantly, NCAPD2 could be a diagnostic marker and an immune related biomarker for LUAD and LUSC.
A scoping review on efficacy and safety of medicinal plants used for the treatment of diarrhea in sub-Saharan Africa
Authors: Plaatjie Moitshepi T. A. , Onyiche ThankGod E. , Ramatla Tsepo , Bezuidenhout Johannes J. , Legoabe Lesetja , Nyembe Nthatisi I. , Thekisoe Oriel 
Published: January 2024

Abstract
Background
In sub-Saharan Africa (SSA), significant morbidity and mortality have been linked to diarrhea, which is frequently caused by microorganisms. A rise in antimicrobial-resistant pathogens has reignited the search for alternative therapies. This scoping review aims to map the literature on medicinal plants in relation to their anti-diarrheal potential from SSA.

Methods
Studies published from 1990 until April 2022 on medicinal plants used for the treatment of diarrhea from each country in SSA were searched on Scopus, Web of Science, Science Direct and PubMed. The selection of articles was based on the availability of data on the in vitro and/or in vivo, ethnobotanical, and cross-sectional studies on the efficacy of medicinal plants against diarrhea. A total of 67 articles (ethnobotanical (n = 40); in vitro (n = 11), in vivo (n = 7), cross-sectional (n = 3), in vitro and in vivo (n = 2) and ethnobotanical and in vitro (n = 2), were considered for the descriptive analysis, which addressed study characteristics, herbal intervention information, phytochemistry, outcome measures, and toxicity findings.

Results
A total of 587 different plant species (from 123 families) used for diarrhea treatment were identified. Most studies were conducted on plants from the Fabaceae family. The plants with the strongest antimicrobial activity were Indigoferadaleoides and Punicagranatum. Chromatographic methods were used to isolate six pure compounds from ethyl acetate extract of Hydnorajohannis, and spectroscopic methods were used to determine their structures. The majority of anti-diarrheal plants were from South Africa (23.9%), Ethiopia (16.4%), and Uganda (9%). This study highlights the value of traditional remedies in treating common human diseases such as diarrhea in SSA.

Conclusion
Baseline knowledge gaps were identified in various parts of SSA. It is therefore recommended that future ethnobotanical studies document the knowledge held by other countries in SSA that have so far received less attention. Additionally, we recommend that future studies conduct phytochemical investigations, particularly on the widely used medicinal plants for the treatment of diarrheal illnesses, which can serve as a foundation for future research into the development of contemporary drugs.
Novel MTR compound-heterozygous mutations in a Chinese girl with HHcy due to methionine synthase deficiency, cblG: a case report
Authors: Luo Juan , Chen Xiaohong , Guo Hongxi , Zhao Peiwei , Yao Hui , Feng Lifang , Yang Luhong 
Published: January 2024

Abstract
Background
The methylcobalamin deficiency G (cblG) disorder, a rare autosomal recessive disease, is attributed to mutations in the MTR gene, resulting in heightened homocysteine levels and reduced methionine and megaloblastic anemia levels. This disease is predominantly diagnosed using MTR gene variation analysis.

Case presentation
Herein, we report the case of a 2.1-month-old Chinese girl with the cblG disorder with poor feeding, failure to thrive, and pancytopenia, esotropia, ocular nystagmus, and hypotonia. However, in order to determine the possible genetic cause of the disease, whole-exome sequencing was adopted and detected compound-heterozygous mutations in MTR gene. One was splicing site mutation c.1812 + 3A > G and the other was missense mutation c.2405G > A (p.A802G), which were likely disease-causing mutations (DM). Variant c.1812 + 3A > G has not been reported before in the literature.

Conclusion
Our data elucidated the genetic etiology of the patient and enriched the known spectrum of mutations in the MTR gene worldwide, offering exhaustive and invaluable insights for early diagnosis and appropriate medication of the cblG disorder.
A 5-kW unidirectional wireless power transfer EV charger with a novel multi-level PFC boost converter on front-end side
Authors: Dakka Obulesu , Patthi Sridhar , Rao J. V. G. Rama , Kumar Parveen 
Published: January 2024

AbstractThe greatest advantages of wireless power transfer (WPT) are its absence of severe environmental hazards, its portability, and its independence from other factors. The wireless charging system for electric vehicles has a serious problem with the amount of misalignment it can tolerate. This study explores the usage of a novel multi-level boost power factor correction (PFC) rectifier with less switch count to improve the efficiency of power conversion of a 5-kW wireless electric vehicle (EV) charger. Especially in the context of wireless charging, which provides convenience and flexibility, there is a pressing need for efficient and dependable charging infrastructure to keep up with the rising demand for electric vehicles. In contrast to wired EV chargers, wireless chargers often have poorer power conversion efficiency because of losses in power semiconductor devices. An innovative multi-level boost PFC rectifier design is offered as a solution to this problem since it uses fewer switches while retaining high-performance levels. The suggested rectifier achieves much higher power conversion efficiency. In addition, power factor correction capabilities are improved, making it comply with global rules. Simpler, cheaper, and more dependable rectifiers improve the whole system.
Anonymous and robust biometric authentication scheme for secure social IoT healthcare applications
Authors: Arpitha T. , Chouhan Dharamendra , Shreyas J. 
Published: January 2024

AbstractIn the era of rapid technological advancement, the Internet of Things (IoT) has revolutionised healthcare through systems like the Telecare Medicine Information System (TMIS), designed to streamline patient-doctor interactions and enhance medical treatment. However, the transmission of sensitive patient data over inherently insecure Internet channels exposes it to a spectrum of security risks. Protecting patient medical privacy and ensuring system reliability necessitate mutual authentication between both patients and medical servers. TMIS relies on robust authentication mechanisms, and combining passwords and smart cards has been a recognised approach for mutual authentication. This research introduces an innovative three-factor authentication technique with perfect forward secrecy by leveraging the power of Elliptic Curve Cryptography (ECC) in tandem with smart cards. Additionally, we have incorporated biometric authentication with a Fuzzy Extractor technology to enhance the security and reliability of the system, setting a new standard for user authentication within the realm of Social IoT healthcare. The use of ECC in the method is justified due to its compact key size and robust security measures, making the solution both efficient and secure. The proposed method safeguards user privacy by permitting registered users to change their passwords without divulging their identity to the server. The Burrows–Abadi–Needham logic (also known as the BAN logic) serves as a proof-of-concept for the proposed scheme’s security. Our system provides privacy protection along with mutual authentication and session key negotiation at a considerably low computation cost and communication cost of up to 71.03% compared to the other four relevant techniques, making it more useful in real-world scenarios.
Finite element solutions of Double diffusion effects on three-dimensional MHD Nano-Powell-Erying fluid flow in presence of thermal and mass Biot numbers
Authors: Gundagani Murali , Mamidi Lakshmi Prasanna , Tanuku Poorna Kantha 
Published: January 2024

AbstractThis work uses a numerical method to investigate the effects of diffusion on the flow of three-dimensional magnetohydrodynamic (MHD) nanofluids. The applicable equations for this problem are derived from the Nano-Powell-Erying fluid model. The result of the differential equation is calculated by solving the problem using the finite element method. The numerical solutions are used to study the three-dimensional structures with the flow of nanofluid to investigate the influence of well-known fluid parameters. The study found that the Hartmann number and buoyancy ratio parameter have a significant impact on the velocity profile, while the Brownian motion and thermophoresis parameters, as well as the thermal and mass Biot numbers, are the main factors influencing the temperature and concentration fields. This study aims to analyse the effect of two different parameters on the flow of MHD nanofluids to improve our basic understanding of this phenomenon. The findings that were produced are compared to the previous work and incipiently, the present numerical results are veritably in good agreement with the previous results. The results of this study can be useful for the optimization and design of various engineering applications.
Case Report: The importance of initial assessment in acute pulmonary embolism
Authors: Ardiana Meity , Hidayat Dwi Fachrul Octafian , Wardhani Louisa Fadjri Kusuma , Devi Putu Dwipa Krisna , Tiksnadi Badai Bhatara 
Published: January 2024

Background: Pulmonary embolism (PE) remains the third most frequent cardiovascular disease worldwide and is associated with high mortality rates. We presented a case of PE with a history of tibial surgery and showed the role of Computed Tomography Pulmonary Angiography (CTPA) in early diagnosis and management of PE. Case presentation: A 23-year-old man was referred to our hospital with sudden dyspnea followed by sharp chest pain, haemoptysis, pre-syncope, diaphoresis, and weaknesses. He had a history of tibial surgery and immobilization one month before admission. His vital sign was unstable, with blood pressure of 110/60 mmHg (supported by Norepinefrin 0.5 mcg/kg/minutes), heart rate of 120 beats/minute, respiratory rate of 24 times/minute, and oxygen saturation of 99% (oxygen mask 6 lpm). An electrocardiogram showed sinus tachycardia with McGinn-White sign. A chest X-ray showed Palla sign. An echocardiogram showed reduced right ventricular systolic function with McConneal sign. CTPA was performed due to the moderate-high risk PE with the presence of hyperattenuating and partial filling defect. Streptokinase was then administered, followed by adequate anticoagulation using rivaroxaban for three months. The clinical and CTPA evaluation showed a good result. Conclusions: Initial assessment using PE’s scoring system will help clinicians determine the needs of CTPA. CTPA has a sensitivity of 53-100% and a specificity of 83-100% for the diagnosis of PE. This makes CTPA mandatory in high-risk PE, thus speeding up the initial treatment, which correlates with clinical outcomes.
Chiral forces in longitudinally invariant dielectric photonic waveguides
Authors: Martínez-Romeu Josep , Diez Iago , Golat Sebastian , Rodríguez-Fortuño Francisco J. , Martínez Alejandro 
Published: January 2024

We calculate numerically the optical chiral forces in rectangular cross-section dielectric waveguides for potential enantiomer separation. Our study considers force strength and time needed for separating chiral nanoparticles, mainly via quasi-TE guided modes at short wavelengths (405 nm) and the 90°-phase-shifted combination of quasi-TE and quasi-TM modes at longer wavelengths (1310 nm). Particle tracking simulations show successful enantiomer separation within two seconds. These results suggest the feasibility of enantiomeric separation of nanoparticles displaying sufficient chirality using simple silicon photonic integrated circuits, with wavelength selection based on the nanoparticle size.
Wafer-level substrate-free YIG single crystal film for a broadband tunable terahertz isolator
Authors: Zhang Xilai , Zhao Dan , Zhang Ding , Xue Qiang , Fan Fei , Liao Yulong , Yang Qinghui , Wen Qiye 
Published: January 2024

Yttrium iron garnet (YIG) is a promising material for various terahertz applications due to its special optical properties. At present, a high-quality YIG wafer is the desire of terahertz communities and it is still challenging to prepare substrate-free YIG single crystal films. In this work, we prepared wafer-level substrate-free La:YIG single crystal films, for the first time, to our knowledge. Terahertz optical and magneto-optical properties of La:YIG films were characterized by terahertz time domain spectroscopy (THz-TDS). Results show that the as-prepared La:YIG film has an insertion loss of less than 3 dB and a low absorption coefficient of less than 10  cm−1 below 1.6 THz. Benefitting from the thickness of the substrate-free YIG films and low insertion loss, their terahertz properties could be further manipulated by simply using a wafer-stacking technique. When four La:YIG films were stacked, there was an insertion loss of less than 10 dB in the range of 0.1−1.2  THz. The Faraday rotation angle of the four-layer-stacked La:YIG films reached 19°, and the isolation could reach 17 dB. By further increasing the stacking number to eight pieces, a remarkable Faraday rotation angle of 45° was achieved with an isolation of 23 dB, which is important for practical application in the THz band. This material may provide a milestone opportunity to make various non-reciprocal devices, such as isolators and phase shifters.
Caliphs and Merchants: Cities and Economies of Power in the Near East (700–950), Fanny Bessard (2020)
Authors: Palombo Cecilia 
Published: January 2024

Review of: Caliphs and Merchants: Cities and Economies of Power in the Near East (700–950), Fanny Bessard (2020)
Oxford: Oxford University Press, 400 pp., 79 b&w and 31 colour illus.,
ISBN: 978-0-19885-582-8, $125 (hardback)
Island of Hope: Migration and Solidarity in the Mediterranean, Megan A. Carney (2021)
Authors: Serrantino Giuseppe 
Published: January 2024

Review of: Island of Hope: Migration and Solidarity in the Mediterranean, Megan A. Carney (2021)
Oakland, CA: California University Press, 223 pp.,
ISBN 978-0-52034-451-8, h/bk, $85, p/bk, $29.95
X Y Z, imágenes de procesos de transformación en el ámbito artístico: Taller de Prácticas del Transitar
Authors: Hernández Rodríguez Álvaro Iván , Cornago Óscar , Rio Forero Daniel del 
Published: January 2024

Este artículo reúne perspectivas, roles y experiencias de tres investigadores que hicieron parte del taller Prácticas de Transitar, realizado en la ciudad de Bogotá, como parte del proyecto TransMigrArts (MSCA RISE 101007587). Dichas se presentan con el fin de realizar una práctica exploratoria (método), la cual tiene como objeto, indagar la noción de transformación, central al proyecto. El proceso mismo de realización del artículo es a su vez una práctica que explora la transformación a través de la materialidad de la escritura, la que va surgiendo de las imágenes del taller y las conversaciones de los tres investigadores sobre la experiencia y la memoria del taller. Es así, que en vez de responder a la pregunta qué es la transformación, la práctica de hacer este trabajo conjunta modos de articular lo que puede hacer la transformación tanto en el taller como en el hacer de este artículo.
Combination of Alginate and Ginger Oil as Edible Coating Formulation for Reducing Pathogenic Bacteria in Litopenaeus vannamei
Authors: Amal Ikhlasul , Yudiati Ervia , Sedjati Sri , Ighwerb Mostafa Imhmed 
Published: January 2024

Litopenaeus vannamei is a world trade commodity that has a high economic value but is easily degraded. To maintain the quality, post-harvest peeled shrimp needs to be coated. The research objective was to determine the effectiveness of adding edible coatings with a formulation of alginate and ginger oil combination as a natural preservative for shrimp. The research method used was laboratory experimental with a completely randomized design (CRD). The treatments were additional peeled shrimp with different concentrations of alginate, i.e. 0 g, 1.5 g, and 3.0 g with two repetitions. The addition of 100 ml aquadest, 4 g CaCl2, 15 mL glycerol, and 1.5 mL of ginger oil was administered in every treatment. Total Plate Counts (TPC), Escherichia coli, and Vibrio cholerae were determined in initial condition, 3rd, and 6th days after the storage time in a 40C refrigerator. The edible film test with 5 repetitions, including thickness, tensile strength, and break elongation. The results on TPC (5.00 x 105 CFU.g-1) and TPC of V. cholerae (Negative.25 g-1) show that all the treated shrimp meet the standard value (SNI 3457:2021) requirements. Most Probably Number of E. coli in alginate addition of 0 and 1.5 g i.e. <3 MPN.g-1 treatments, do not meet the requirements. The bacterial test and edible film mechanical properties showed that the addition of 3.0 g alginate was the most effective treatment compared to other treatments (α=0.05). A formulation of alginate and ginger oil combination is an effective edible coating for reducing the pathogenic bacteria of peeled shrimp L. vannamei.
A nurturing and caring environment to facilitate nursing students’ professional development in Rwanda: a focused ethnographic study
Authors: Umubyeyi Benoite , Babenko-Mould Yolanda , Hynie Michaela , Regan Sandra , Leipert Beverly 
Published: January 2024

AbstractObjectivesTo explore the values, practices, and behaviours that support nursing students’ professional development in practice-based learning environments in Rwanda.MethodsA focused ethnographic approach was used. Nursing students (n=12), nurses (n=11), clinical instructors (n=7) and nurse leaders (n=8) from three teaching hospitals and an educational program participated in the study. Data was collected trough individual interviews and participant observation.ResultsParticipants embraced a culture of preparing nursing students for their professional roles as a professional responsibility, and a means of securing the nursing profession. Modeling the appropriate behaviours to students and respecting them as learners and humans constituted the caring attributes that sustain a positive learning environment for their professional growth.ConclusionsNurturing and caring environments offer students opportunities to integrate caring attitudes into their interactions with patients and to develop professionally.Implications for international audienceFindings underscore the need to enhance caring values within nursing curricula.
Discourse markers as the locus of signaling the main-event line in Alsea narratives
Authors: Shirtz Shahar 
Published: January 2024

Abstract
This article argues that in Alsea ([aes]; Penutian/isolate; dormant; Oregon Coast) the main event line (mel) of narratives is reliably signaled by a particular combination of clause-initial particles, functioning as discourse markers, and not by a specific set of verb forms, the means usually identified and discussed in the literature as a cue for the mel status of a clause. The strength of the link between this combination of discourse markers and the mel, then, represents a cross-linguistic situation that seems rare. Alsea has a rich system of discourse markers and a rich system of verbal affixes, with over 20 potentially co-occurring markers in each. The relative wealth of these discourse markers and their potential combinations make an intricate system of signaling the syntactic, semantic, and pragmatic relationship between clauses and their immediate environment, essentially signaling their discourse status. One combination of markers has the function of signaling the mel. Alsea verbal affixes, on the other hand, play a major role in event semantics and aspectual construal, but a minor one in discourse structuring. This allows for seemingly paradoxical uses of irrealis or imperfective verb forms on the mel of narratives, where the later coerces the event into specific types of bounded and realis readings.