bluuebunny/crossref_metadata_2025_split huggingface dataset:
Counting hiddenness: cognitive science and the distribution of belief in God
Authors: Green Adam 
Published: October 2023

AbstractEstablishing the distribution of belief in something, especially something that spans cultures and times, requires close attention to empirical evidence and to certain inadequacies in our concept of belief. Arguments from divine hiddenness have quickly become one of the most important argument types in the philosophy of religion. These arguments and responses to them typically rely on robust but relatively undefended empirical commitments as to the distribution of belief in God. This article synthesizes results from psychology, anthropology, and the cognitive science of religion to show that the distribution of belief in God is much more messy and much more philosophically interesting than is currently appreciated. I then derive some implications for how one might reconceive the hiddenness debate in light of these findings.
Perception of cognitive change by individuals with Parkinson’s disease or essential tremor seeking deep brain stimulation: Utility of the cognitive change index
Authors: Rodriguez Katie , Schade Rachel N. , Lopez Francesca V. , Kenney Lauren E. , Ratajska Adrianna M. , Gertler Joshua , Bowers Dawn 
Published: October 2023

AbstractObjective:The Cognitive Change Index (CCI-20) is a validated questionnaire that assesses subjective cognitive complaints (SCCs) across memory, language, and executive domains. We aimed to: (a) examine the internal consistency and construct validity of the CCI-20 in patients with movement disorders and (b) learn how the CCI-20 corresponds to objective neuropsychological and mood performance in individuals with Parkinson’s disease (PD) or essential tremor (ET) seeking deep brain stimulation (DBS).Methods:216 participants (N = 149 PD; N = 67 ET) underwent neuropsychological evaluation and received the CCI-20. The proposed domains of the CCI-20 were examined via confirmatory (CFA) and exploratory (EFA) factor analyses. Hierarchical regressions were used to assess the relationship among subjective cognitive complaints, neuropsychological performance and mood symptoms.Results:PD and ET groups were similar across neuropsychological, mood, and CCI-20 scores and were combined into one group who was well educated (m = 15.01 ± 2.92), in their mid-60’s (m = 67.72 ± 9.33), predominantly male (63%), and non-Hispanic White (93.6%). Previously proposed 3-domain CCI-20 model failed to achieve adequate fit. Subsequent EFA revealed two CCI-20 factors: memory and non-memory (p < 0.001; CFI = 0.924). Regressions indicated apathy and depressive symptoms were associated with greater memory and total cognitive complaints, while poor executive function and anxiety were associated with more non-memory complaints.Conclusion:Two distinct dimensions were identified in the CCI-20: memory and non-memory complaints. Non-memory complaints were indicative of worse executive function, consistent with PD and ET cognitive profiles. Mood significantly contributed to all CCI-20 dimensions. Future studies should explore the utility of SCCs in predicting cognitive decline in these populations.
Comparing meat and meat alternatives: an analysis of nutrient quality in five European countries
Authors: Petersen Thies , Hirsch Stefan 
Published: October 2023

AbstractObjective:To assess and compare the (macro-)nutritional composition of red meat (RM) and poultry meat (PM) products with the emerging category of meat substitutes.Design:We use information on nutritional values per 100 g to estimate the differences in the nutritional composition between RM, PM, vegan meat substitute (VMS) and non-vegan meat substitute (NVMS) and derive six unique meat product clusters to enhance the comparability.Setting:Meat markets from five major European countries: France, Germany, UK, Italy and Spain.Participants/Data:Product innovation data for 19 941 products from Mintel’s Global New Product Database from 2010 to 2020.Results:Most of the innovations in the sample are RM products (55 %), followed by poultry (30 %), VMS (11 %) and NVMS (5 %). RM products exhibit a significantly higher energy content in kcal/100 g as well as fat, saturated fat, protein and salt all in g/100 g than the meatless alternatives, while the latter contain significantly more carbohydrates and fibre than either poultry or RM. However, results differ to a certain degree when products are grouped into more homogeneous clusters like sausages, cold cuts and burgers. This indicates that general conclusions regarding the health effects of substituting meat with plant-based alternatives should only be drawn in relation to comparable products.Conclusions:Meat substitutes, both vegan and non-vegan, are rated as ultra-processed foods. However, compared with RM products, they and also poultry products both can provide a diet that contains fewer nutrients-to-limit, like salt and saturated fats.
Europe’s constitutional retrofit
Authors: Walker Neil 
Published: October 2023

AbstractThe various and diverse academic responses to the Conference on the Future of Europe’s efforts at democratic renewal, including those by Ben Crum, Markus Patberg and Sandra Seubert, speak not only to the lack of a clear institutional locus or pathway associated with the Conference, but also to differing understandings of the basic conditions of existence – or political ontology – of the European Union. These differing understandings are reflected in different attitudes to the European Union’s constitutional standing and prospects. This article explores how the special place of constitutional retrofitting in the European Union – of reconstructing and reimagining an originally pre-constitutional system in constitutional terms – helps to illuminate the different understanding of political ontology in play, and helps clarify what is at stake in the continuing debate over fundamental reform.
Envisioning Empire from Inside the United States: Exile, Constitutional Monarchism, and Ethnic Conflict in Post-Independence Mexico
Authors: González Quintero Nicolás Alejandro 
Published: October 2023

AbstractThis article examines Tiburcio Campe's newspaper El Español, a brief yet concerted effort by exiled Spanish liberals in New Orleans that drew on the Cádiz constitutional experiment to demand the return of imperial rule in Mexico in the late 1820s. Exiled from Mexico as a consequence of the expulsion laws against Spaniards (españoles), Campe used his newspaper to criticize republican exclusionary policies and to militate against a possible expansion of abolitionism, ethnic conflict, and anti-white proposals in the Caribbean, promoting imperial constitutionalism as the only guarantor of the coexistence of Spaniards and Americanos and racial hierarchies in the Americas. Discussions regarding political and racial equality in Mexico and the United States, and the community's experience of exile in New Orleans, shaped these ideas, revealing how the banishment of Campe and other Spanish liberals renewed their advocacy of empire. Moreover, their exile in the United States facilitated their participation in the transatlantic public sphere and the circulation of their work, illustrating how the United States became a platform for envisioning and propagating imperial endeavors. Thus a study of El Español and Tiburcio Campe's actions allows us to comprehend the intricacies between exile and pro-monarchical discourses, as well as the nature of political and racial equality in the post-independence Americas.
Phylogenomics reveals the history of host use in mosquitoes
Authors: Soghigian John , Sither Charles , Justi Silvia Andrade , Morinaga Gen , Cassel Brian K. , Vitek Christopher J. , Livdahl Todd , Xia Siyang , Gloria-Soria Andrea , Powell Jeffrey R. , Zavortink Thomas , Hardy Christopher M. , Burkett-Cadena Nathan D. , Reeves Lawrence E. , Wilkerson Richard C. , Dunn Robert R. , Yeates David K. , Sallum Maria Anice , Byrd Brian D. , Trautwein Michelle D. , Linton Yvonne-Marie , Reiskind Michael H. , Wiegmann Brian M. 
Published: October 2023

AbstractMosquitoes have profoundly affected human history and continue to threaten human health through the transmission of a diverse array of pathogens. The phylogeny of mosquitoes has remained poorly characterized due to difficulty in taxonomic sampling and limited availability of genomic data beyond the most important vector species. Here, we used phylogenomic analysis of 709 single copy ortholog groups from 256 mosquito species to produce a strongly supported phylogeny that resolves the position of the major disease vector species and the major mosquito lineages. Our analyses support an origin of mosquitoes in the early Triassic (217 MYA [highest posterior density region: 188–250 MYA]), considerably older than previous estimates. Moreover, we utilize an extensive database of host associations for mosquitoes to show that mosquitoes have shifted to feeding upon the blood of mammals numerous times, and that mosquito diversification and host-use patterns within major lineages appear to coincide in earth history both with major continental drift events and with the diversification of vertebrate classes.
Systematic functional interrogation of SARS-CoV-2 host factors using Perturb-seq
Authors: Sunshine Sara , Puschnik Andreas S. , Replogle Joseph M. , Laurie Matthew T. , Liu Jamin , Zha Beth Shoshana , Nuñez James K. , Byrum Janie R. , McMorrow Aidan H. , Frieman Matthew B. , Winkler Juliane , Qiu Xiaojie , Rosenberg Oren S. , Leonetti Manuel D. , Ye Chun Jimmie , Weissman Jonathan S. , DeRisi Joseph L. , Hein Marco Y. 
Published: October 2023

AbstractGenomic and proteomic screens have identified numerous host factors of SARS-CoV-2, but efficient delineation of their molecular roles during infection remains a challenge. Here we use Perturb-seq, combining genetic perturbations with a single-cell readout, to investigate how inactivation of host factors changes the course of SARS-CoV-2 infection and the host response in human lung epithelial cells. Our high-dimensional data resolve complex phenotypes such as shifts in the stages of infection and modulations of the interferon response. However, only a small percentage of host factors showed such phenotypes upon perturbation. We further identified the NF-κB inhibitor IκBα (NFKBIA), as well as the translation factors EIF4E2 and EIF4H as strong host dependency factors acting early in infection. Overall, our study provides massively parallel functional characterization of host factors of SARS-CoV-2 and quantitatively defines their roles both in virus-infected and bystander cells.
Dynamic metastable polymersomes enable continuous flow manufacturing
Authors: Wong Chin Ken , Lai Rebecca Y. , Stenzel Martina H. 
Published: October 2023

AbstractPolymersomes are polymeric analogues of liposomes with exceptional physical and chemical properties. Despite being dubbed as next-generation vesicles since their inception nearly three decades ago, polymersomes have yet to experience translation into the clinical or industrial settings. This is due to a lack of reliable methods to upscale production without compromising control over polymersome properties. Herein we report a continuous flow methodology capable of producing near-monodisperse polymersomes at scale (≥3 g/h) with the possibility of performing downstream polymersome manipulation. Unlike conventional polymersomes, our polymersomes exhibit metastability under ambient conditions, persisting for a lifetime of ca. 7 days, during which polymersome growth occurs until a dynamic equilibrium state is reached. We demonstrate how this metastable state is key to the implementation of downstream processes to manipulate polymersome size and/or shape in the same continuous stream. The methodology operates in a plug-and-play fashion and is applicable to various block copolymers.
Developing cognitive workload and performance evaluation models using functional brain network analysis
Authors: Shadpour Saeed , Shafqat Ambreen , Toy Serkan , Jing Zhe , Attwood Kristopher , Moussavi Zahra , Shafiei Somayeh B. 
Published: October 2023

AbstractCognition, defined as the ability to learn, remember, sustain attention, make decisions, and solve problems, is essential in daily activities and in learning new skills. The purpose of this study was to develop cognitive workload and performance evaluation models using features that were extracted from Electroencephalogram (EEG) data through functional brain network and spectral analyses. The EEG data were recorded from 124 brain areas of 26 healthy participants conducting two cognitive tasks on a robot simulator. The functional brain network and Power Spectral Density features were extracted from EEG data using coherence and spectral analyses, respectively. Participants reported their perceived cognitive workload using the SURG-TLX questionnaire after each exercise, and the simulator generated actual performance scores. The extracted features, actual performance scores, and subjectively assessed cognitive workload values were used to develop linear models for evaluating performance and cognitive workload. Furthermore, the Pearson correlation was used to find the correlation between participants’ age, performance, and cognitive workload. The findings demonstrated that combined EEG features retrieved from spectral analysis and functional brain networks can be used to evaluate cognitive workload and performance. The cognitive workload in conducting only Matchboard level 3, which is more challenging than Matchboard level 2, was correlated with age (0.54, p-value = 0.01). This finding may suggest playing more challenging computer games are more helpful in identifying changes in cognitive workload caused by aging. The findings could open the door for a new era of objective evaluation and monitoring of cognitive workload and performance.
Mapping sexual dimorphism signal in the human cranium
Authors: Del Bove Antonietta , Menéndez Lumila , Manzi Giorgio , Moggi-Cecchi Jacopo , Lorenzo Carlos , Profico Antonio 
Published: October 2023

AbstractThe study of sexual dimorphism in human crania has important applications in the fields of human evolution and human osteology. Current, the identification of sex from cranial morphology relies on manual visual inspection of identifiable anatomical features, which can lead to bias due to user’s expertise. We developed a landmark-based approach to automatically map the sexual dimorphism signal on the human cranium. We used a sex-known sample of 228 individuals from different geographical locations to identify which cranial regions are most sexually dimorphic taking into account shape, form and size. Our results, which align with standard protocols, show that glabellar and supraciliary regions, the mastoid process and the nasal region are the most sexually dimorphic traits (with an accuracy of 73%). The accuracy increased to 77% if they were considered together. Surprisingly the occipital external protuberance resulted to be not sexually dimorphic but mainly related to variations in size. Our approach here applied could be expanded to map other variable signals on skeletal morphology.
Ectopic pregnancy: search for biomarker in salivary proteome
Authors: Priya Aarthy Archunan , Sen Sangeetha , Srinivasan Mahalingam , Muthukumar Subramanian , Madhanraj Pakirisamy , Akbarsha Mohammad Abdulkader , Archunan Govindaraju 
Published: October 2023

AbstractEctopic pregnancy (EP) is associated with high maternal morbidity and mortality. Ultrasonography is the only dependable diagnostic tool for confirming an ectopic pregnancy. In view of inadequate early detection methods, women suffer from a high-life risk due to the severity of EP. Early detection of EP using pathological/molecular markers will possibly improve clinical diagnosis and patient management. Salivary proteins contain potential biomarkers for diagnosing and detecting various physiological and/or pathological conditions. Therefore, the present investigation was designed to explore the salivary proteome with special reference to EP. Gel-based protein separation was performed on saliva, followed by identification of proteins using Liquid Chromatography-Tandem Mass Spectrometry (LC–MS/MS). Totally, 326 proteins were identified in the salivary samples, among which 101 were found to be specific for ruptured ectopic pregnancy (EPR). Reactome analysis revealed innate immune system, neutrophil degranulation, cell surface interactions at the vascular wall, and FCERI-mediated NF-kB activation as the major pathways to which the salivary proteins identified during EPR are associated. Glutathione-S-transferase omega-1 (GSTO1) is specific for EPR and has been reported as a candidate biomarker in the serum of EPR patients. Therefore, saliva would be a potential source of diagnostic non-invasive protein biomarker(s) for EP. Intensive investigation on the salivary proteins specific to EP can potentially lead to setting up of a panel of candidate biomarkers and developing a non-invasive protein-based diagnostic kit.
Increased risk of ischemic stroke associated with elevated gamma-glutamyl transferase level in adult cancer survivors: a population-based cohort study
Authors: Kim Kyuwoong , Jung Hyeyun , Di Giovanna Edvige , Jun Tae Joon , Kim Young-Hak 
Published: October 2023

AbstractAdult cancer survivors may have an increased risk of developing ischemic stroke, potentially influenced by cancer treatment-related factors and shared risk factors with stroke. However, the association between gamma-glutamyl transferase (GGT) levels and the risk of ischemic stroke in this population remains understudied. Therefore, our study aimed to examine the relationship between GGT levels and the risk of ischemic stroke using a population-based cohort of adult cancer survivors. A population-based cohort of adult cancer survivors was derived from the National Health Insurance Service-Health Screening Cohort between 2003 and 2005 who survived after diagnosis of primary cancer and participated in the biennial national health screening program between 2009 and 2010. Cox proportional hazards model adjusted for sociodemographic factors, health status and behavior, and clinical characteristics was used to investigate the association between GGT level and ischemic stroke in adult cancer survivors. Among 3095 adult cancer survivors, 80 (2.58%) incident cases of ischemic stroke occurred over a mean follow-up of 8.2 years. Compared to the lowest GGT quartile, the hazard ratios (HRs) for ischemic stroke were 1.56 (95% CI 0.75–3.26), 2.36 (95% CI 1.12–4.99), and 2.40 (95% CI 1.05–5.46) for the second, third, and fourth sex-specific quartiles, respectively (Ptrend = 0.013). No significant effect modification was observed by sex, insurance premium, and alcohol consumption. High GGT level is associated with an increased risk of ischemic stroke in adult cancer survivors independent of sex, insurance premium, and alcohol consumption.
Stochastic co-teaching for training neural networks with unknown levels of label noise
Authors: de Vos Bob D. , Jansen Gino E. , Išgum Ivana 
Published: October 2023

AbstractLabel noise hampers supervised training of neural networks. However, data without label noise is often infeasible to attain, especially for medical tasks. Attaining high-quality medical labels would require a pool of experts and their consensus reading, which would be extremely costly. Several methods have been proposed to mitigate the adverse effects of label noise during training. State-of-the-art methods use multiple networks that exploit different decision boundaries to identify label noise. Among the best performing methods is co-teaching. However, co-teaching comes with the requirement of knowing label noise a priori. Hence, we propose a co-teaching method that does not require any prior knowledge about the level of label noise. We introduce stochasticity to select or reject training instances. We have extensively evaluated the method on synthetic experiments with extreme label noise levels and applied it to real-world medical problems of ECG classification and cardiac MRI segmentation. Results show that the approach is robust to its hyperparameter choice and applies to various classification tasks with unknown levels of label noise.
Association between number of medications and hip fractures in Japanese elderly using conditional logistic LASSO regression
Authors: Uematsu Takuya , Kawakami Yuta , Nojiri Shuko , Saito Tomoyuki , Irie Yoshiki , Kasai Takatoshi , Hiratsuka Yoshimune , Ishijima Muneaki , Kuroki Manabu , Daida Hiroyuki , Nishizaki Yuji 
Published: October 2023

AbstractTo examine the association between hip fracture and associated factors, including polypharmacy, and develop an optimal predictive model, we conducted a population-based matched case–control study using the health insurance claims data on hip fracture among Japanese patients. We included 34,717 hospitalized Japanese patients aged ≥ 65 years with hip fracture and 34,717 age- and sex- matched controls who were matched 1:1. This study included 69,434 participants. Overall, 16 variable comorbidities and 60 variable concomitant medications were used as explanatory variables. The participants were added to early elderly and late elderly categories for further analysis. The odds ratio of hip fracture increased with the number of medications only in the early elderly. AUC was highest for early elderly (AUC, 0.74, 95% CI 0.72–0.76). Use of anti-Parkinson’s drugs had the largest coefficient and was the most influential variable in many categories. This study confirmed the association between risk factors, including polypharmacy and hip fracture. The risk of hip fracture increased with an increase in medication number taken by the early elderly and showed good predictive accuracy, whereas there was no such association in the late elderly. Therefore, the early elderly in Japan should be an active target population for hip fracture prevention.
Chronic inflammation does not mediate the effect of adiposity on grip strength: results from a multivariable Mendelian randomization study
Authors: Norris Tom , Sanderson Eleanor , Cooper Rachel , Garfield Victoria , Pereira Snehal M. Pinto 
Published: October 2023

AbstractThe relationship between adiposity and grip strength (GS) is complex. We investigated whether one pathway through which adiposity affects GS was via chronic inflammation. 367,583 UK Biobank participants had body mass index (BMI), waist-hip-ratio (WHR), C-reactive protein (CRP) and GS data. Univariable Mendelian randomization (MR) and multivariable Mendelian randomization (MVMR) analyses (using inverse variance weighted (IVW) weighted median estimates (WME) and MR-Egger models) estimated total, direct and indirect effects of adiposity traits on GS using genetic instruments for BMI and WHR (exposures) and CRP (mediator). Observational findings suggested higher BMI was associated with stronger grip, e.g., in males, per standard deviation (SD) higher BMI, GS was higher by 0.48 kg (95% confidence interval(CI):0.44,0.51), independent of CRP. For males MR estimates were directionally consistent; for females, estimates were consistent with the null. Observational findings for WHR suggested that higher WHR was associated with weaker grip. In multivariable MR-IVW analyses, effects in males were consistent with the null. In females, there were consistent effects such that higher WHR was associated with stronger grip, e.g., 1-SD higher WHR was associated with 1.25 kg (MVMR-Egger; 95% CI:0.72,1.78) stronger grip, independent of CRP. Across sexes and adiposity indicators, CRP’s mediating role was minor. Greater adiposity may increase GS in early old age, but effects vary by sex and adiposity location. There was no evidence that inflammation mediated these effects.