bluuebunny/crossref_metadata_2025_split huggingface dataset:
Evaluating Response to a Cognitive Behavioural Therapy for Psychosis‐Informed Family Intervention at Variable Duration of a Psychotic Illness
Authors: Stiles Bryan J. , Kuczynski Adam M. , Shepard Victoria , Blank Jennifer , Kopelovich Sarah L. 
Published: January 2025

ABSTRACTObjectiveEarly intervention in psychosis is associated with favourable outcomes. We investigated whether loved ones' illness duration moderated caregiver outcomes following a Cognitive Behavioural Therapy‐informed Family Intervention for psychosis (FIp).MethodsWe conducted a secondary analysis of measures of FIp participants' depression and anxiety symptoms, caregiver appraisals, expressed emotion and foundational psychotherapeutic competencies at pre‐, post‐ and 4‐month follow‐up. Our primary aim was to evaluate whether duration of illness moderated participant outcomes.ResultsRelative to pre‐intervention, all caregivers reported lower depression, anxiety and expressed emotion, as well as higher positive attitudes and mastery of cognitive behavioural skills, at post‐intervention and 4‐month follow‐up. Outcomes were not moderated by their loved one's illness duration.ConclusionFamilies may benefit equally from FIp regardless of illness duration. Although we recommend that FIp are offered as early as possible, modifications for families with lengthier illness courses are not implicated by our findings.
Exploring the Effect of Brief Preventive Videos on Mental Health Help‐Seeking for Early Psychosis in a Young Community Sample
Authors: Dondé Clément , Jambon Louise , Wilhelm Marie‐Claire , Bortolon Catherine 
Published: January 2025

ABSTRACTIntroductionA key factor influencing the duration of untreated psychosis is that young individuals typically do not seek help during their initial psychotic experiences. This online study aimed to explore the efficacy of preventive video interventions providing information on psychosis on the attitudes towards seeking mental health care among young adults from the general population.MethodsParticipants (N = 147) were randomised to one of the following online conditions: a short 3‐min video of an empowered patient or of a psychiatrist describing different aspects of mental illness, a short control video or no video. Then, participants answered the Inventory of Attitudes to Seeking Mental Health Services (IARSSM) to measure attitudes towards seeking mental health.ResultsA Kruskal–Wallis one‐way ANOVA on the total IARSSM score revealed no significant effect of the group on attitude towards mental health care (χ2(3) = 6.52, p = 0.09). A small but statistically significant effect was found for the IARSSM factor “indifference to stigma” (χ2(3) = 8.50, p = 0.04), with slightly lower levels of indifference to stigma in the patient video group (M = 20.5, SD = 6.50) compared to the psychiatry video group (M = 24.5, SD = 4.35).ConclusionEmphasising nonconformity with mental health stereotypes, portraying positive aspects and utilising short video formats on social media platforms can potentially reduce stigma in the short term. Long‐term effectiveness and identification of specific factors optimising attitudes towards mental health help‐seeking warrant further investigation.
Concentration‐ and Size‐Dependent Influences of Microplastics on Soil Hydraulic Properties and Water Flow
Authors: Feng Haoxuan , Xing Xuguang , Du Jianqiang , Jiao Sihan , Yu Miao , Wang Weihua 
Published: January 2025

ABSTRACTExtensive usage of agricultural plastic film correspondingly leads to excessive residues of microplastics (MPs). MP accumulation alters soil hydraulic properties and water flow. However, little is known about the combined effects of concentration and particle size on soil hydrological properties, and a numerical approach for modelling infiltrated flow has not been well developed. Hence, we determined soil hydraulic properties and infiltrated flow affected by MP concentration and particle size and established a water flow model suitable for MP‐contaminated soils. Quantitative findings indicated that the saturated conductivity for soil–MP mixture was 10.8%–50.0% smaller than that for pure soil, which decreased and increased with the increase in MP concentration and size, respectively. The MP concentration always had significant influences on saturated conductivity; in contrast, the MP particle size always generated significant influences under the condition of small particle size. Besides, higher concentration or size of MPs led to weaker soil water‐holding capacity, and the saturated and residual water content decreased by 0.6% – 41.5% and 0.2% – 11.6%, respectively. Furthermore, the presence of MPs inhibited water infiltration, with the wetting front migration rate and cumulative infiltration decreased by 7.1% – 29.4% and 4.7% – 21.7%, respectively, with the increase in the MP concentration and size. Correlation analysis indicated that MP particle size was negatively correlated with saturated/residual moisture, wetting front migration and cumulative infiltration; in addition, MP concentration was negatively correlated with saturated conductivity, residual moisture, wetting front migration and cumulative infiltration; compared with the MP particle size (15.63%), the MP concentration (46.28%) played a major role in the response of soil hydraulic properties and water movement to changes in the external environment. A two‐dimensional numerical approach was proposed by considering the Richards equation and hydraulic parameters of soil–MP mixture, and a model based on finite element theory was further employed and validated through comparing experimental observations with numerical simulations, which indicated that the proposed model had a high accuracy in simulating the infiltration process in MP‐contained soils. Our findings elucidate the influence of MP concentration and size on soil hydraulic properties and water flow and confirm the potential of using simulations to predict water infiltration in MP‐contained soils.
Fibroblast transcriptomics uncovers pathogenic genomic variants in individuals with exome‐negative childhood onset epilepsy
Authors: Smal Noor , Millevert Charissa , De Wachter Matthias , De Vriendt Els , Eddafir Zakaria , Schoonjans An‐Sofie , Bayat Allan , Møller Rikke Steensbjerre , Mei Davide , Balestrini Simona , Guerrini Renzo , Meeuwissen Marije E. C. , Jansen Anna C. , Weckhuysen Sarah 
Published: January 2025

AbstractObjectiveThis study aims to improve genetic diagnosis in childhood onset epilepsy with neurodevelopmental problems by utilizing RNA sequencing of fibroblasts to identify pathogenic variants that may be missed by exome sequencing and copy number variation analysis.MethodsWe enrolled 41 individuals with childhood onset epilepsy and neurodevelopmental problems who previously had inconclusive genetic testing. Fibroblast samples were cultured and analyzed using RNA sequencing to detect aberrant expression, aberrant splicing, and monoallelic expression using the Detection of RNA Outlier Pipeline (DROP) pipeline. Detected events were correlated with phenotypes, and long‐read genome sequencing was performed on individuals with strong candidate events to identify the causal genomic variant. A systematic literature review on RNA sequencing in rare disorders was conducted to contextualize our findings.ResultsRNA sequencing identified five strong candidate events in four individuals, affecting the genes QRICH1, TSC1, SMARCA1, GNAI1, and PTEN. (Likely) pathogenic genomic variants affecting expression of QRICH1, TSC1, and SMARCA1 were detected, resulting in a diagnostic yield of 7% (3/41). Two variants were not covered in the initial exome sequencing data but were revealed through long‐read sequencing. The identification of a pathogenic TSC1 variant led to a previously unrecognized diagnosis of tuberous sclerosis complex. This prompted guideline‐based screening, which revealed tuberous sclerosis lesions in the brain and lung, directly impacting clinical care. Notably, two of the three pathogenic events would not have been detected using whole blood due to the lack of expression of the involved genes. The lower yield of this study compared to studies in other rare disorders reflects the genetic heterogeneity of epilepsy and neurodevelopmental disorders, and the inaccessibility of affected tissue.SignificanceThis research underscores RNA sequencing of cultured fibroblasts as a valuable tool in genetic diagnostics for childhood onset epilepsy, particularly when conventional methods fail. Expanding the control dataset with age‐matched samples and incorporating RNA sequencing with nonsense‐mediated decay inhibition could further enhance diagnostic yield.
Prioritizing questions and topics for the development of guidelines and consensus‐based recommendations supported by ILAE: A scoping review and proposal of prioritization criteria
Authors: Lin Katia , Eyal Sara , Demarchi Izabel Galhardo , Ben‐Shushan Tomer , Auvin Stéphane , Khoo Ching Soong , Al‐Baradie Raidah , Sen Arjune , Newton Charles , Ngwende Gift Wilson , Candez Nicelle de Morais , Sperling Michael , Brigo Francesco , Jette Nathalie , Wiebe Samuel ,   the Standards and Best Practice Council—Prioritization Task Force
Published: January 2025

AbstractClinical practice guidelines (CPGs) and consensus‐based recommendations (CBRs) require considerable effort, collaboration, and time—all within the constraints of finite resources. Professional societies, such as the International League Against Epilepsy (ILAE), must prioritize what topics and questions to address. Implementing evidence‐based care remains a crucial challenge in clinical practice. Using rigorous processes to ensure that the best available research evidence informs health care recommendations is of the utmost importance. We aimed to develop a structured and transparent process for prioritizing future CPGs and CBRs supported by the ILAE. A multidisciplinary group of researchers and experts from the ILAE Prioritization Task Force conducted a scoping review to identify prioritization approaches for CPG and CBR development. This scoping review was reported according to the Preferred Reporting Items for Systematic reviews and Meta‐Analyses extension for Scoping Reviews (PRISMA‐ScR) and Cochrane recommendations. A Problem/population, Concept, and Context (PCC) strategy was applied to the literature search and selection of the studies. We searched Medline/PubMed, Embase, Web of Science, and Scopus without time or language limits. The findings were synthesized qualitatively. A consensus‐based process was followed to develop a prioritization scoring tool for CPGs and another for CBRs. Thirty‐nine participants, including clinicians, experts in the field, methodologists, and other relevant stakeholders, contributed to developing the final instrument (based on a 5‐point Likert scale). Of 721 unique citations, 8 papers reporting prioritization approaches for guideline development were included. Based on these, we developed an initial tool with 10 criteria. It was iteratively optimized and revised by the ILAE Standards and Best Practice Council, which unanimously approved the instrument. The ILAE Executive Committee subsequently approved its final version. The ILAE Prioritization Tool is intended to standardize the prioritization processes and optimize the ILAE's use of resources to select CPGs and CBRs for endorsement.
The impact of cultural competence in family law: An overview of Buddhism, Islam, Hinduism, and Judaism
Authors: Moore‐Grant Tracy Ann , Robins Stephanie , Saxena Neena , Siotia Suchika 
Published: January 2025

AbstractIn contemporary multicultural societies, the family law profession requires a nuanced understanding of diverse cultural backgrounds to facilitate equitable and effective resolutions. Cultural competence in the family law profession entails recognizing and respecting the beliefs, values, and practices of individuals from different cultural backgrounds. Understanding the impact of religion on family dynamics, decision‐making processes, and conflict resolution is essential for family law professionals to navigate sensitive issues such as divorce, custody arrangements, and parental rights. By delving into the teachings, traditions, and rituals of Buddhism, Islam, Hinduism, and Judaism, this paper elucidates the unique cultural considerations that influence family law disputes within these religious communities. It examines key aspects such as dietary preferences, religious observances, and extended family dynamics, shedding light on how these factors shape co‐parenting arrangements and legal proceedings. Furthermore, this paper underscores the importance of incorporating cultural sensitivity into the family law process to promote mutual understanding, respect, and cooperation among parties. By fostering an environment where diverse religious perspectives are acknowledged and valued, mediators can facilitate more equitable and satisfactory outcomes for families from different cultural backgrounds. Ultimately, this paper advocates for the integration of cultural competence training into family law practices, emphasizing the need for mediators to continuously educate themselves on the religious and cultural nuances of the diverse populations they serve. By embracing cultural competence, family law practitioners can better serve the needs of all families, regardless of their religious affiliations, and contribute to a more inclusive and just legal system.
Assessing the reliability and feasibility of quality indicators used to evaluate long‐term care for older adults
Authors: Kawase Kiyomi , Igarashi Ayumi , Eltaybani Sameh , Yasaka Taisuke , Sumikawa Yuka , Takaoka Manami , Kashiwabara Kosuke , Fukui Chie , Yamamoto‐Mitani Noriko 
Published: January 2025

AimStandardized quality indicators for long‐term care (QIs‐LTC) were previously developed to ensure high‐quality holistic nursing care for older adults. This research aimed to assess the feasibility and reliability of unfavorable health outcomes measured by the QIs‐LTC and proposed strategies for improvement.MethodsThirty‐nine pairs of home care nurses assessed 53 clients. We evaluated 20 of the 21 items of feasibility to calculate scores for the “I do not know” answer and test the interrater reliability using bias‐adjusted and prevalence‐adjusted kappa (PABAK). We then conducted interviews with 16 home care nurses to collect feedback on the implementation of QIs‐LTC. Based on this feedback, we developed the QIs‐LTC assessment manual and reassessed the QIs‐LTC when used with the manual.ResultsThe mean for the “I do not know” answer was 13.8%, and the mean PABAK was 0.75 (±0.28). Overall, the reliability was good for physical assessment but inadequate for social aspects. Using the assessment manual, the mean for the “I do not know” answers decreased to 10.4%. The mean PABAK was 0.77 (±0.32) and increased for 12 unfavorable health outcomes.ConclusionsThe feasibility and reliability of most unfavorable health outcomes were ensured by using the newly developed assessment manual. Challenges in education and practice of social aspects were identified. QIs‐LTC support individual and agency evaluations, nursing interventions and quality evaluations, which are a priority for long‐term care in Japan. Geriatr Gerontol Int 2025; ••: ••–••.
Epstein–Barr Virus‐Induced 3 Attributes to TLR7‐Mediated Splenomegaly
Authors: Iseki Masanori , Sakamoto Yuma , Takezaki Daiki , Matsuda Yoshihiro , Inoue Mariko , Morizane Shin , Mukai Tomoyuki 
Published: January 2025

ABSTRACTEpstein–Barr virus‐induced 3 (EBI3) functions as a component of the heterodimer cytokine IL‐27, which regulates innate and acquired immune responses. The expression of EBI3 gene is induced by Toll‐like receptors (TLRs). Repeated treatment with imiquimod (IMQ), a TLR7 agonist, induces splenomegaly and cytopaenia due to increased splenic function. Although immune cell activation is speculated to play a role in chronic infection‐mediated splenomegaly, the detailed mechanisms remain unknown. This study shows that IMQ treatment induces marked splenomegaly and severe bicytopaenia (anaemia and thrombocytopaenia) in wild‐type mice. In IMQ‐treated mice, myeloid cell populations in the spleen increased, and extramedullary haematopoiesis was observed. RNA‐seq analysis revealed the upregulation of type I interferon (IFN)‐related genes in the spleens of IMQ‐treated mice. IMQ‐induced pathological changes were partially mitigated by EBI3 deficiency. To investigate the mechanism of the improved phenotypes in the Ebi3 KO mice, we examined the involvement of IL‐27, a heterodimer of EBI3 and IL‐27p28. The expression of Il27a, which encodes IL‐27p28, was increased in the spleen and peripheral blood by IMQ treatment. Furthermore, IL‐27 stimulation upregulated type I IFN‐related genes in bone marrow‐derived macrophage cultures without type I IFN. These findings suggest that EBI3 deficiency mitigated IMQ‐mediated pathological changes, presumably via a lack of IL‐27 formation. Our study thus provides insights into the molecular mechanisms underlying chronic infection‐mediated splenomegaly.
Self‐Management in Children and Adolescents With Chronic Illness: An Evolutionary Analysis of the Concept
Authors: Catarino Marta , Macedo Lúcia , Santos Joana , Charepe Zaida , Festas Constança 
Published: January 2025

ABSTRACTAimTo increase conceptual clarity regarding the self‐management of school‐age children and adolescents with chronic illnesses in a community context.DesignConcept Analysis: Rodgers' evolutionary approach.Data SourcesSearch conducted in the Cumulative Index to Nursing and Allied Health Literature, Psychology and Behavioural Sciences Collection, Nursing and Allied Health Collection, Academic Search Complete, Cochrane, Web of Science, Medical Literature Analysis and Retrieval System Online, Scopus, Repositório Científico de Acesso Aberto de Portugal, ProQuest Dissertations and Theses, Joanna Briggs Institute Evidence Synthesis. Thirty‐one articles were identified, published between 2004 and 2023.Reporting MethodFollowed the Enhancing the Quality and Transparency of Health Research guidelines—Preferred Reporting Items for Systematic Reviews and Meta‐Analyses 2020.ResultsSelf‐management in children and adolescents with chronic illness, in school age, in a community context, consists of a process of acquiring knowledge and beliefs that promote the self‐efficacy of this population in developing skills to face needs inherent to the health condition.ConclusionPromoting self‐management goes beyond simply educating for skill acquisition. Participants with stronger beliefs in their ability to control their behaviours are more successful in self‐management. The activation of resources that position the child as an agent of change is recommended.Implications for the Profession and/or Patient CareIt contributes to the development of strategies that promote self‐management across different healthcare disciplines, focusing on education and change, but also on psychological encouragement to foster confidence in change.ImpactCompetent self‐management during childhood promotes autonomy, empowerment, and control of the condition, with consequent physical and emotional well‐being, quality of life, family stability, and social development.No Patient or Public ContributionThere was no direct contribution from patients or the public in this work (literature review).
Exploring Individual and Team Resilience Among Dutch Hospital Nurses: A Survey Study
Authors: van Stralen Sharon A. , Schlinkert Caroline , van Eikenhorst Linda , Wagner Cordula 
Published: January 2025

ABSTRACTBackgroundNurses confront substantial daily workloads. Coping mechanisms, including resilient behaviours at both individual and team levels, are pivotal in managing these challenges. Factors like work experience can significantly influence individual resilience. Yet, team resilience among nurses remains relatively unexplored.AimOur study examined perceptions of both individual and team resilience among Dutch hospital nurses. Furthermore, we investigated the impacts of hospital type, ward type and work experience.MethodsThe Employee Resilience Scale was used to evaluate individual resilience and adapted for team contexts to assess team resilience. This study was one of three conducted under a governmental research program aimed at improving patient safety in the Netherlands. A paired t‐test and correlation analysis were conducted to compare individual resilience with team resilience. A separate t‐test assessed the impact of ward type on perceived individual and team resilience. Finally, post hoc analyses were used to examine the effects of hospital type and work experience.ResultsIn total, 344 nurses from 25 different wards of 17 Dutch hospitals completed the survey. In general, nurses indicated to act more resilient on the individual level (mean = 3.77, SD = 0.61) compared to the team level (mean = 3.53, SD = 0.65; t = 7.25, p = 0.00). A correlation was found between perceived individual and team resilience (r = 0.53, p = 0.00). No effects of hospital‐ and ward type were found on both individual or team resilience. Years of work experience did not affect individual resilience but showed a significant effect on team resilience.ConclusionDutch hospital nurses indicated they often act resilient on both individual and team levels. However, with increasing workloads in healthcare, being able to remain resilient will become increasingly challenging and important. Organisations should therefore support employees to maintain resilience by adapting their work environment to meet more employees' needs.
Epicardial Adipose Tissue and Left Ventricular Hypertrophy in Hypertensive Patients With Preserved Ejection Fraction: A Multicenter Retrospective Cohort Study
Authors: Zhu Runze , Wang Wenxian , Gao Yan , Liu Junchuan , Li Bowen , Shan Rongxue , Xue Runjie , Yuan Xianshun , Wang Xi‐Ming 
Published: January 2025

ABSTRACTThis study aimed to investigate the correlation of the increased volume index of epicardial adipose tissue (EAT) and left ventricular hypertrophy (LVH) in patients with Hypertension (HTN). A total of 209 HTN patients and 50 healthy controls, who underwent cardiovascular magnetic resonance (CMR) at two medical centers in China between June 2015 and October 2024, were enrolled for this study. Postprocessing and imaging analysis were conducted and EAT measurements were performed. Restricted cubic splines (RCS) were used to explore the potential relationship with LVH. Binary logistic regression models and mediation analyses were employed to evaluate the association between EAT volume and CMR parameters as well as LVH. Hypertensive patients with LVH exhibited larger indexed EAT volumes, more pronounced diffuse fibrosis, and reduced left ventricular strain compared to hypertensive patients without LVH (all p < 0.001), with results remaining stable after adjusting for confounding factors. The variables that were significant in the univariate regression were included in the multivariate logistic regression model, indicating that indexed EAT volume (p = 0.001), extracellular volume (ECV) (p = 0.012), and global longitudinal strain (GLS) (p = 0.024) were independently associated with LVH. These associations remained stable after adjusting for confounding factors. Mediation analysis further revealed that the relationship between increased EAT volume and LVH was mediated by ECV, native T1, GLS, global circumferential strain (GCS), and global radial strain (GRS) (p < 0.05). These findings imply that EAT is independently linked to LVH in hypertensive patients. The association between EAT and LVH in hypertensive patients may be mediated by myocardial fibrosis or dysfunction.