bluuebunny/crossref_metadata_2025_split huggingface dataset:
Inter‐ and intra‐session variability of compression strain gauge for the adductor groin squeeze test on soccer athletes
Authors: McMinn Kieran J. , Diewald Shelley N. , Harrison Craig , Cronin John B. , Ye‐Lee Dana ,   Paris Saint Germain
Published: January 2024

AbstractThe importance of hip adductor strength for injury prevention and performance benefits is well documented. The purpose of this study was to establish the intra‐ and inter‐day variability of peak force (PF) of a groin squeeze protocol using a custom‐designed compression strain gauge device. Sixteen semi‐professional soccer players completed three trials over three separate testing occasions with at least 24‐h rest between each session. The main findings were that the compression strain gauge was a reliable device for measuring PF within and between days. All intraclass correlations were higher than 0.80 and coefficients of variations were below 10% across the different sessions and trials. Due to the information gained through the compression strain gauge, the higher sampling frequency utilized, portability, and the relatively affordable price, this device offers an effective alternative for measuring maximal strength for hip adduction.
Hormonal stories: a new materialist exploration of hormonal emplotment in four case studies
Authors: Erikainen Sonja , Ford Andrea , Malcolm Roslyn , Raeder Lisa 
Published: January 2024

AbstractHormones are complex biosocial objects that provoke myriad cultural narratives through their association with social activities and identities, and these narratives have the power to shape people’s lived realities and bodies. While hormones were historically conceptualised as ‘master molecules’ capable of controlling various life processes, their explanatory potential has now been overshadowed by technoscientific developments like omics- and gene-based biotechnologies that have reframed how human bodies and behaviours are understood. Considering these shifts, this paper asks what roles hormones perform and what stories they are arousing today. Through a patchwork of four hormone stories about contraception, gender hacking, birth, and autism-specific horse therapy, we show how hormones remain vital protagonists in the constitution of bodies, affects, environments, places, politics, and selves in the contemporary period. Building on new materialist approaches, we adopt and extend the notion of ‘emplotment’ to encapsulate how hormones act as key characters in our plots. They are working to complicate dominant understandings of what bodies are and can be in new ways as they mediate different plots of bodily experience, in ways showing the ongoing powerful salience of hormones and their ascendancy in the present.
Acute facial neuralgia related to initiation of emtricitabine/tenofovir for HIV PrEP: a report of two cases in a PrEP demonstration trial
Authors: Yin Zhuoheng , Tan Rayner Kay Jin , Tucker Joseph D. , Li Quanmin , Sherer Renslow , Li Linghua , Tang Weiming 
Published: January 2024

Background Emtricitabine (FTC) and tenofovir disoproxil fumarate (TDF) fixed-dose combination (FTC/TDF) is generally well-tolerated, although treatment-related adverse events have been reported. Methods We report two cases of persons using FTC/TDF PrEP who had acute neuralgia in a Chinese PrEP demonstration trial. Results Neurological symptoms subsided upon treatment discontinuation. Symptoms were reported as similar to one case’s previous experiences with dolutegravir (DTG) + FTC + tenofovir alafenamide (TAF) (for PEP), leading to permanent discontinuation of PrEP. Conclusion Acute facial neuralgia appears to be a rare idiosyncratic adverse event to FTC/TDF.
Conceptions of sexual health by gay men living with HIV in serodifferent couples in Montreal, Canada: results from a qualitative analysis
Authors: Avallone Francesco , Engler Kim , Cox Joseph , Hickson Ford , Lessard David , Bourdon Jeanne , Thomas Réjean , Lebouché Bertrand 
Published: January 2024

Background Gay, bisexual, and other men (GBM) who have sex with men living with HIV in serodifferent couples (one partner living with HIV, the other HIV-negative) may encounter unique sexual health challenges. This study aimed to explore their definition of sexual health that could improve service provision. Methods We interviewed 10 gay-identified men living with HIV from 2017 to 2019 as part of CTNPT013, a study on the sexual health of HIV serodifferent GBM couples conducted at two HIV-specialised clinics in Montreal, Canada. Participants partook in semi-structured interviews on the meaning of sexual health. We performed a content analysis of interview transcripts, coding them according to the 10 dimensions of Robinson’s Sexual Health Model. Results Mean age of interviewees was 35.4 years (s.d.,10.2; range, 20–53). Every dimension of Robinson’s model was spontaneously evoked, except for body image and spirituality. All men indicated intimacy/relationships (e.g. sexual agreements) and sexual health care/safer sex (e.g. HIV management, risk behaviours) as relevant aspects of sexual health. Other dimensions included: positive sexuality (n = 7), such as pleasure and enjoyment during sex; talking about sex (n = 5), which mainly concerned HIV disclosure; sexual functioning (n = 4); challenges to sexual health (n = 3), including substance abuse; and culture/sexual identity (n = 3). Two participants (n = 2) cited masturbation/fantasy. Conclusions This study emphasises the multi-faceted nature of sexual health for gay men with HIV in serodifferent couples and the pivotal roles of relationships, HIV, risk management (e.g. via health care, knowledge), and positive sexual experiences. These dimensions could be considered in sexual health promotion interventions targeting this population.
PM-CNN: microbiome status recognition and disease detection model based on phylogeny and multi-path neural network
Authors: Wang Qiangqiang , Fan Xiaoqian , Wu Shunyao , Su Xiaoquan 
Published: January 2024

AbstractMotivationThe human microbiome, found throughout various body parts, plays a crucial role in health dynamics and disease development. Recent research has highlighted microbiome disparities between patients with different diseases and healthy individuals, suggesting the microbiome’s potential in recognizing health states. Traditionally, microbiome-based status classification relies on pre-trained machine learning (ML) models. However, most ML methods overlook microbial relationships, limiting model performance.ResultsTo address this gap, we propose PM-CNN (Phylogenetic Multi-path Convolutional Neural Network), a novel phylogeny-based neural network model for multi-status classification and disease detection using microbiome data. PM-CNN organizes microbes based on their phylogenetic relationships and extracts features using a multi-path convolutional neural network. An ensemble learning method then fuses these features to make accurate classification decisions. We applied PM-CNN to human microbiome data for status and disease detection, demonstrating its significant superiority over existing ML models. These results provide a robust foundation for microbiome-based state recognition and disease prediction in future research and applications.Availability and implementationPM-CNN software is available at https://github.com/qdu-bioinfo/PM_CNN.
Intronless Pabpc6 encodes a testis-specific, cytoplasmic poly(A)-binding protein but is dispensable for spermatogenesis in the mouse
Authors: Kaku Yuko , Isono Yuka , Tanaka Hideto , Kobayashi Tomohiro , Kanemori Yoshinori , Kashiwabara Shin-ichi 
Published: January 2024

Abstract
Besides ubiquitous poly(A)-binding protein, cytoplasmic 1 (PABPC1), testis-specific PABPC2/PABPt (in humans, referred to as PABPC3), and female and male germline-specific PABPC1L/ePAB, have been reported in the mouse testis. Recent in silico analysis additionally identified testis-specific Pabpc6 in the mouse. In this study, we characterized PABPC6 and its mutant mice. PABPC6 was initially detectable in the cytoplasm of pachytene spermatocytes, increased in abundance in round spermatids, and decreased in elongating spermatids. PABPC6 was capable of binding to poly(A) tails of various mRNAs and interacting with translation-associated factors, including EIF4G, PAIP1, and PAIP2. Noteworthy was that PABPC6, unlike PABPC1, was barely associated with translationally active polysomes and enriched in chromatoid bodies of round spermatids. Despite these unique characteristics, neither synthesis of testicular proteins nor spermatogenesis was affected in the mutant mice lacking PABPC6, suggesting that PABPC6 is functionally redundant with other co-existing PABPC proteins during spermatogenesis.
Early outcomes of transcatheter arterial embolization using imipenem/cilastatin for plantar fasciitis refractory to conservative therapy
Authors: Gandhi Rozil , Banker Mohal 
Published: January 2024

Abstract

Objective
The conservative therapy for chronic plantar fasciitis works for a few patients, while surgical options have drawbacks. Before considering surgical options, transcatheter arterial embolization may help patients with plantar fasciitis who are experiencing discomfort resistant to conservative treatment.

Methods
We report evaluation data of 10 patients treated with transcatheter arterial embolization using imipenem/cilastatin as embolic agents to relieve chronic pain due to plantar fasciitis. All the patients were refractory to conservative therapy.

Results
The technical success of the procedure was found to be 100%. Further, effective pain relief was observed as there was no pain relapse in 6 months, and patients did not require any other form of therapy.

Conclusion
This report warrants further adequately designed randomized clinical studies for evaluating the efficacy of transcatheter arterial embolization in plantar fasciitis.

Advances in knowledge
Resorting to surgical option for chronic pain relief in plantar fasciitis might be reconsidered and replaced with arterial embolization. However, adequately designed long-term clinical studies are required to prove its long-term efficacy.
Design-based identification with formula instruments: A review
Authors: Borusyak Kirill , Hull Peter , Jaravel Xavier 
Published: January 2024

SummaryMany studies in economics use instruments or treatments that combine a set of exogenous shocks with other predetermined variables via a known formula. Examples include shift-share instruments and measures of social or spatial spillovers. We review recent econometric tools for this setting, which leverage the assignment process of the exogenous shocks and the structure of the formula for identification. We compare this design-based approach with conventional estimation strategies based on conditional unconfoundedness, and contrast it with alternative strategies that leverage a model for unobservables.
Integrated microbiota–host–metabolome approaches reveal adaptive ruminal changes to prolonged high-grain feeding and phytogenic supplementation in cattle
Authors: Ricci Sara , Pacífico Cátia , Kreuzer-Redmer Susanne , Castillo-Lopez Ezequias , Rivera-Chacon Raul , Sener-Aydemir Arife , Rossi Giacomo , Galosi Livio , Biagini Lucia , Schwartz-Zimmermann Heidi E , Berthiller Franz , Reisinger Nicole , Petri Renee M , Zebeli Qendrim 
Published: January 2024

AbstractDiets rich in readily fermentable carbohydrates primarily impact microbial composition and activity, but can also impair the ruminal epithelium barrier function. By combining microbiota, metabolome, and gene expression analysis, we evaluated the impact of feeding a 65% concentrate diet for 4 weeks, with or without a phytogenic feed additive (PFA), on the rumen ecosystem of cattle. The breaking point for rumen health seemed to be the second week of high grain (HG) diet, with a dysbiosis characterized by reduced alpha diversity. While we did not find changes in histological evaluations, genes related with epithelial proliferation (IGF-1, IGF-1R, EGFR, and TBP) and ZO-1 were affected by the HG feeding. Integrative analyses allowed us to define the main drivers of difference for the rumen ecosystem in response to a HG diet, identified as ZO-1, MyD88, and genus Prevotella 1. PFA supplementation reduced the concentration of potentially harmful compounds in the rumen (e.g. dopamine and 5-aminovaleric acid) and increased the tolerance of the epithelium toward the microbiota by altering the expression of TLR-2, IL-6, and IL-10. The particle-associated rumen liquid microbiota showed a quicker adaptation potential to prolonged HG feeding compared to the other microenvironments investigated, especially by the end of the experiment.
Awakening the sleeping giant: Epstein–Barr virus reactivation by biological agents
Authors: Indari Omkar , Ghosh Subhrojyoti , Bal Adhiraj Singh , James Ajay , Garg Mehek , Mishra Amit , Karmodiya Krishanpal , Jha Hem Chandra 
Published: January 2024

Abstract
Epstein–Barr virus (EBV) may cause harm in immunocompromised conditions or on stress stimuli. Various chemical agents have been utilized to induce the lytic cycle in EBV-infected cells. However, apart from chemical agents and external stress stimuli, certain infectious agents may reactivate the EBV. In addition, the acute infection of other pathogens may provide suitable conditions for EBV to thrive more and planting the roots for EBV-associated pathologies. Various bacteria such as periodontal pathogens like Aggregatibacter, Helicobacter pylori, etc. have shown to induce EBV reactivation either by triggering host cells directly or indirectly. Viruses such as Human simplex virus-1 (HSV) induce EBV reactivation by HSV US3 kinase while other viruses such as HIV, hepatitis virus, and even novel SARS-CoV-2 have also been reported to cause EBV reactivation. The eukaryotic pathogens such as Plasmodium falciparum and Aspergillus flavus can also reactivate EBV either by surface protein interaction or as an impact of aflatoxin, respectively. To highlight the underexplored niche of EBV reactivation by biological agents, we have comprehensively presented the related information in this review. This may help to shedding the light on the research gaps as well as to unveil yet unexplored mechanisms of EBV reactivation.
Spatial variation in shallow slow earthquake activity in Hyuga-nada, southwest Japan
Authors: Baba Satoru , Takemura Shunsuke , Obara Kazushige , Takeo Akiko , Yamashita Yusuke , Shinohara Masanao 
Published: January 2024

SUMMARY
Hyuga-nada, off the Pacific coast of Kyushu along the Nankai Trough in southwest Japan, is one of the most active slow earthquake regions around Japan. We estimated the energies of shallow tremors and moments of shallow very low frequency earthquakes (VLFEs) in Hyuga-nada using data from a permanent onshore broadband network and temporary ocean–bottom seismometer observations. The energies and moments of these slow earthquakes have a similar along-strike variation and are generally higher south of the subducted Kyushu–Palau Ridge than near the top of the ridge. This spatial variation is also related to the characteristics of slow earthquake migration. The along-strike migration speed was faster at initiation in the south, where the moments of slow earthquakes are higher. After migration entered the subducted Kyushu–Palau Ridge, its speed was decelerated with a parabolic pattern and their moments became smaller. Assuming a constant patch size of slow earthquakes, we estimated that the stress drop of VLFEs in the south of the subducted ridge was approximately three times higher than that near the top of the subducted ridge. According to our observations and a physical model, this stress drop difference between adjacent regions may cause parabolic migration. We also estimated the scaled energy of slow earthquakes from the ratio of the seismic energy rates of tremors to the seismic moment rates of accompanying VLFEs. The spatial variation in scaled energy is not identified inside the Hyuga-nada. Since the range of scaled energy is similar between the south and near the top of the subducted ridge, the apparent stress may be similar if the rigidity is the same. The dominant range of scaled energy of slow earthquakes in Hyuga-nada is 10−11.5–10−8.5. In addition to having similar or one order smaller values compared to other slow earthquake regions, the range of scaled energy in Hyuga-nada is broader. This broader range suggests wide range of characteristic time and various spectral features of slow earthquakes in Hyuga-nada. Based on a Brownian slow earthquake model, the wide range of characteristic time in this area suggests width variations of slow earthquake source area.
Multifidelity adaptive sequential Monte Carlo for geophysical inversion
Authors: Amaya M , Meles G , Marelli S , Linde N 
Published: January 2024

SUMMARY
In the context of Bayesian inversion, we consider sequential Monte Carlo (SMC) methods that provide an approximation of the posterior probability density function and the evidence (marginal likelihood). These particle approaches build a sequence of importance sampling steps between gradually tempered distributions evolving from the prior to the posterior PDF. To automate the definition of the tempering schedule, adaptive SMC (ASMC) allows tuning the temperature increments on-the-go. One general challenge in Bayesian inversions is the computational burden associated with expensive, high-fidelity forward solvers. Lower-fidelity surrogate models are interesting in this context as they can emulate the response of expensive forward solvers at a fraction of their cost. We consider surrogate modelling within ASMC and introduce first an approach involving surrogate modelling only, in which either prior samples are used to train the surrogate, or the surrogate model is retrained by updating the training set during the inversion. In our implementation, we rely on polynomial chaos expansions for surrogate modelling, principal component analysis for model parametrization and a ground-penetrating radar cross-hole tomography problem with either an eikonal or finite-difference time-domain solver as high-fidelity solver. We find that the method based on retraining the surrogate during the inversion outperforms the results obtained when only considering prior samples. We then introduce a computationally more expensive multifidelity approach including a transition to the high-fidelity forward solver at the end of the surrogate-based ASMC run leading to even more accurate results. Both methods result in speed-ups that are larger than one order of magnitude compared to standard high-fidelity ASMC inversion.
Topography effect on seismic waveform tomography: a quantitative study
Authors: Zheng Kaiyue , Wang Yi , Zhao Li 
Published: January 2024

SUMMARY
In seismic tomography practices the Earth's surface is sometimes assumed to be either spherical or flat for convenience in forward modelling calculations. The effect of irregular surface topography on seismic wave propagation is thus ignored, resulting in biases in the phases and amplitudes of synthetic seismograms, which contribute to the residuals that are mapped into velocity structures in tomography inversions. In this study, we conduct a series of inversion experiments based on the adjoint waveform tomography method to quantitatively assess the topography effect on waveform-based inversion results. We first employ models with simplified topography to better highlight and quantify the topography effect. Results show that when topography effect is ignored in the forward modelling, it is mapped into velocity perturbations, leading to spurious velocity anomalies in tomography models. The strength of the spurious velocity anomaly is quasi-linearly related to locally averaged topography gradient. Our inversion experiments demonstrate that in places of strong topography variation, such as the Longmenshan Fault Zone region where the 2008 Mw 7.9 Wenchuan earthquake occurred, topography effect can lead to spurious relative velocity anomalies of up to 10 per cent, which cannot be ignored in waveform-based tomography inversions.
Artificial age-independent seismic anisotropy, slab thickening and shallowing due to limited resolving power of (an)isotropic tomography
Authors: Rappisi F , Witek M , Faccenda M , Ferreira A M G , Chang S - J 
Published: January 2024

SUMMARY
Seismic anisotropy is key to constrain mantle flow, but it is challenging to image and interpret it. Existing large-scale tomography models of seismic anisotropy typically show large discrepancies, which can lead to completely distinct geodynamical interpretations. To better quantify the robustness of anisotropy tomography, we create a 2-D ridge-to-slab geodynamic model and compute the associated fabrics. Using the resulting 21 elastic constants, we compute seismic full waveforms, which are inverted for isotropic and radially anisotropic structure. We test the effects of different data coverage and levels of regularization on the resulting images and on their geodynamical interpretation. Within the context of our specific imposed conditions and source–receiver configuration, the retrieved isotropic images exhibit substantial artificial slab thickening and loss of the slab’s high-velocity signature below ∼100 km depth. Our results also show that the first-order features of radial anisotropy are well retrieved despite strong azimuthal anisotropy (up to 2.7 per cent) in the input model. On the other hand, regularization and data coverage strongly control the detailed characteristics of the retrieved anisotropy, notably the depth–age dependency of anisotropy, leading to an artificial flat depth–age trend shown in existing anisotropy tomography models. Greater data coverage and additional complementary data types are needed to improve the resolution of (an)isotropic tomography models.
VapC10 toxin of the legume symbiont Sinorhizobium meliloti targets tRNASer and controls intracellular lifestyle
Authors: Syska Camille , Kiers Aurélie , Rancurel Corinne , Bailly-Bechet Marc , Lipuma Justine , Alloing Geneviève , Garcia Isabelle , Dupont Laurence 
Published: January 2024

Abstract
The soil bacterium Sinorhizobium meliloti can establish a nitrogen-fixing symbiosis with the model legume Medicago truncatula. The rhizobia induce the formation of a specialized root organ called nodule, where they differentiate into bacteroids and reduce atmospheric nitrogen into ammonia. Little is known on the mechanisms involved in nodule senescence onset and in bacteroid survival inside the infected plant cells. Although toxin-antitoxin (TA) systems have been shown to promote intracellular survival within host cells in human pathogenic bacteria, their role in symbiotic bacteria was rarely investigated. S. meliloti encodes several TA systems, mainly of the VapBC family. Here we present the functional characterization, through a multidisciplinary approach, of the VapBC10 TA system of S. meliloti. Following a mapping by overexpression of an RNase in Escherichia coli (MORE) RNA-seq analysis, we demonstrated that the VapC10 toxin is an RNase that cleaves the anticodon loop of two tRNASer. Thereafter, a bioinformatics approach was used to predict VapC10 targets in bacteroids. This analysis suggests that toxin activation triggers a specific proteome reprogramming that could limit nitrogen fixation capability and viability of bacteroids. Accordingly, a vapC10 mutant induces a delayed senescence in nodules, associated to an enhanced bacteroid survival. VapBC10 TA system could contribute to S. meliloti adaptation to symbiotic lifestyle, in response to plant nitrogen status.