bluuebunny/crossref_metadata_2025_split huggingface dataset:
Superposed fracture networks
Authors: Peacock D.C.P. , Sanderson D.J. , Magán M. 
Published: December 2023

AbstractThe concept of superposed fracture networks consisting of different generations, and often types, of fractures that have developed sequentially is discussed. Superposed networks can consist of different types of extension or shear fractures, and each fracture may abut, cross or follow (reactivate) earlier fractures. An example of a superposed fracture network in Liassic limestones in Somerset, UK, is presented, which comprises two sets of veins and a later joint network. The veins develop as damage zones around faults, with veins of the later set crossing or trailing along the earlier set. The later joints either cross-cut the earlier veins or reactivate them, the latter being common for the thicker (more than about 5 mm) veins. The veins and joint networks have markedly different geometries and topologies. The veins are spatially clustered and are typically dominated by I-nodes, while the joints are more evenly distributed and tend to be dominated by Y-nodes. The combined network of veins and joints at Lilstock is dominated by X-nodes because so many joints cross-cut the earlier veins. Understanding the development of superposed fracture networks leads to better understanding of the kinematic, mechanical, tectonic and fluid flow history of rocks.
Climate change effects on terrestrial parasitic nematodes: Where are the knowledge gaps?
Authors: Moerman T.M. , Albon S.D. , Coulson S.J. , Loe L.E. 
Published: December 2023

Abstract
Climate change is expected to affect parasitic nematodes and hence possibly parasite–host dynamics and may have far-reaching consequences for animal health, livestock production, and ecosystem functioning. However, there has been no recent overview of current knowledge to identify how studies could contribute to a better understanding of terrestrial parasitic nematodes under changing climates. Here we screened almost 1,400 papers to review 57 experimental studies on the effects of temperature and moisture on hatching, development, survival, and behaviour of the free-living stages of terrestrial parasitic nematodes with a direct life cycle in birds and terrestrial mammals. Two major knowledge gaps are apparent. First, research should study the temperature dependency curves for hatching, development, and survival under various moisture treatments to test the interactive effect of temperature and moisture. Second, we specifically advocate for more studies that investigate how temperature, and its interaction with moisture, affect both vertical and horizontal movement of parasitic nematodes to understand infection risks. Overall, we advocate for more field experiments that test environmental effects on life-history traits and behaviour of parasitic nematodes in their free-living stages under natural and realistic circumstances. We also encourage studies to expand the range of used hosts and parasitic nematodes because 66% of results described in the available studies use sheep and cattle as hosts and 32% involve just three nematode species. This new comprehension brings attention to understudied abiotic impacts on terrestrial parasitic nematodes and will have broader implications for livestock management, wildlife conservation, and ecosystem functioning in a rapidly warming climate.
Development and Evaluation of a Nurse Practitioner Huddles Toolkit for Long Term Care Homes
Authors: Krassikova Alexandra , Wills Aria , Vellani Shirin , Sidani Souraya , Keatings Margaret , Boscart Veronique M. , Bethell Jennifer , McGilton Katherine S. 
Published: December 2023

AbstractLong-term care homes (LTCHs) were disproportionately affected by the coronavirus disease (COVID-19) pandemic, creating stressful circumstances for LTCH employees, residents, and their care partners. Team huddles may improve staff outcomes and enable a supportive climate. Nurse practitioners (NPs) have a multifaceted role in LTCHs, including facilitating implementation of new practices. Informed by a community-based participatory approach to research, this mixed-methods study aimed to develop and evaluate a toolkit for implementing NP-led huddles in an LTCH. The toolkit consists of two sections. Section one describes the huddles’ purpose and implementation strategies. Section two contains six scripts to guide huddle discussions. Acceptability of the intervention was evaluated using a quantitative measure (Treatment Acceptability Questionnaire) and through qualitative interviews with huddle participants. Descriptive statistics and manifest content analysis were used to analyse quantitative and qualitative data. The project team rated the toolkit as acceptable. Qualitative findings provided evidence on design quality, limitations, and recommendations for future huddles.
Is bilingualism linked to well-being? Evidence from a big-data survey
Authors: Wang Jing , Wei Rining 
Published: December 2023

AbstractIn applied linguistics generally and bilingualism research in particular, psychological variables remain a much under-investigated sub-category of individual differences compared with cognitive ones. To better understand the under-researched psychological effects of bilingualism, this study investigated well-being, a psychological construct, based on a big-data survey. Drawing upon a national survey (N = 12,582), we examined the influence of bilingualism (operationalised as foreign language (FL) proficiency) and 13 sociobiographical variables (e.g., socio-economic status, SES) on well-being. Among these 14 initial independent variables, perceived social fairness, SES, and health emerged as important predictors for well-being, with FL proficiency and national language (NL) proficiency as potentially important predictors; crucially, FL proficiency was more important than NL proficiency. As the first systematic attempt to link bilingualism with well-being, our study advocates (1) a more holistic perspective towards language (including NL and FL(s)) in any bilingual context and (2) fuller use of effect sizes.
Asymmetric conflation: QAnon and the political cooptation of religion
Authors: Foertsch Steven , Chakraborty Rudra , Joosse Paul 
Published: December 2023

AbstractQAnon is beginning to gain attention in scholarly circles, but these sources often disagree about how to categorize the movement. This amounts to the meta-dispute between those who view QAnon primarily as a religious “cult,” and those who grant it greater credibility as a political populist movement. Using quantitative and qualitative methods we test the proposition that QAnon could be a mix of both. Results from both analyses suggest that QAnon is best understood primarily as a political populist movement, but one that utilizes religious rhetoric. The findings thus highlight the asymmetric nature of the conflation of religion and politics in the contemporary American civil sphere.
Message in a Bottle—An Update to the Golden Record: 1. Objectives and Key Content of the Message
Authors: Jiang Jonathan H. , Berea Anamaria , Bowden Heather , Das Prithwis , Fahy Kristen A. , Ginsberg Joseph , Jew Robert , Jiang Xiaoming , Kershenbaum Arik , Kipping David , Lau Graham , Lewis Karen , Nuñez Lendo C. Isabel , Rosen Philip E. , Searra Nick , Taylor Stuart F. , Traphagan John 
Published: December 2023

AbstractIn the first part of this series, we delve into the foundational aspects of “Message in a Bottle (MIAB)” (henceforth referred to as MIAB). This study builds upon the legacy of the Voyager Golden Records, launched aboard Voyager 1 and 2 in 1977, which aimed to communicate with intelligent species beyond our world. These records not only offer a snapshot of Earth and human civilization but also represent our desire to establish contact with advanced alien civilizations. Given the absence of mutually understood signs, symbols, and semiotic conventions, MIAB, like its predecessor, uses scientific methods to design an innovative means of communication that encapsulates the story of humanity. Our goal is to share our collective knowledge, emotions, innovations, and aspirations in a way that provides a universal, yet contextually relevant, understanding of human society, the evolution of life on Earth, and our hopes and concerns for the future. Through this time and space traveling capsule, we also strive to inspire and unify current and future generations to celebrate and safeguard our shared human experience.
Comparison of Ring Current Proton Losses Between Contributions From Scattering by Field Line Curvature and EMIC Waves
Authors: Cao Xing , Ni Binbin , Yu Yiqun , Ma Longxing , Lu Peng , Wang Xiaoyu 
Published: December 2023

AbstractAlthough both the field line curvature (FLC) and electromagnetic ion cyclotron (EMIC) waves are recognized to contribute importantly to the loss of energetic protons in the Earth's ring current, their quantitative differences in scattering ring current protons are still not fully understood. In this study, using a realistic, nondipolar magnetic field model, we perform a detailed analysis of the scattering effects of ring current protons and the resultant proton lifetimes due to FLC and EMIC waves at different L‐shells under different levels of geomagnetic activity. We find that compared with EMIC wave‐driven scattering, FLC scattering has a stronger dependence on L‐shell and geomagnetic activity. Pitch angle scattering efficiency due to FLC enhances significantly as proton energy increases. In contrast, scattering by H+ band EMIC waves tends to be weaker with increasing proton energy, while the scattering rates by He+ band EMIC waves increase first and then decrease. The results of proton lifetime against pitch angle scattering show that EMIC wave‐driven scattering dominates the loss of ring current protons at lower L‐shells (L < 6), especially during geomagnetically quiet conditions. During geomagnetically active conditions at L ≥ 6, EMIC wave‐driven scattering dominates at lower proton energies, while FLC scattering dominates at higher proton energies. This study improves the current understanding of the relative contributions of scattering by FLC and EMIC waves to the Earth's ring current proton dynamics.
Quantification of Water Released by Thawing Permafrost in the Source Region of the Yangtze River on the Tibetan Plateau by InSAR Monitoring
Authors: Wang Lingxiao , Zhao Lin , Zhou Huayun , Liu Shibo , Liu Guangyue , Zou Defu , Du Erji , Hu Guojie , Wang Chong 
Published: December 2023

AbstractThe source region of the Yangtze River (SRYR, 1.4 × 105 km2 above Zhimenda station) on the Tibetan Plateau (TP) has 78% permafrost coverage. The streamflow depth increased at a rate of 2.5 mm/a since 2000. Quantification of the water contribution brought by permafrost thawing is a difficult task. In this study, we used Sentinel‐1 data and the SBAS‐InSAR technique to monitor terrain deformation from September 2016 to December 2021, and then utilized the long‐term deformation rate to assess ground ice meltwater release and the seasonal deformation to evaluate water storage in the active layer. Results reveal that 55.3% of the terrain in the SRYR has subsidence >2.5 mm/a, indicating widespread ground ice melting. The release rate of ground ice meltwater is 4.3 mm/a in the entire SRYR, above 6 mm/a at the Dangqu and Tuotuo River subbasins. The water release rate is relatively small (∼3%) in comparison to the streamflow depth of 151 mm per year during the investigation period of 2017–2021. We did not detect a strong increasing or decreasing trend among the 5‐year seasonal deformation, which reflects that the total soil water content in the active layer did not change significantly during the short investigation period. The results provide a data basis for ground ice richness and loss information in the SRYR and help to understand the impact of permafrost thawing on the regional water cycle in the permafrost environment.
MYCN and SNRPD3 cooperate to maintain a balance of alternative splicing events that drives neuroblastoma progression
Authors: Salib Alice , Jayatilleke Nisitha , Seneviratne Janith A. , Mayoh Chelsea , De Preter Katleen , Speleman Frank , Cheung Belamy B. , Carter Daniel R. , Marshall Glenn M. 
Published: December 2023

AbstractMany of the pro-tumorigenic functions of the oncogene MYCN are attributed to its regulation of global gene expression programs. Alternative splicing is another important regulator of gene expression and has been implicated in neuroblastoma development, however, the molecular mechanisms remain unknown. We found that MYCN up-regulated the expression of the core spliceosomal protein, SNRPD3, in models of neuroblastoma initiation and progression. High mRNA expression of SNRPD3 in human neuroblastoma tissues was a strong, independent prognostic factor for poor patient outcome. Repression of SNRPD3 expression correlated with loss of colony formation in vitro and reduced tumorigenicity in vivo. The effect of SNRPD3 on cell viability was in part dependent on MYCN as an oncogenic co-factor. RNA-sequencing revealed a global increase in the number of genes being differentially spliced when MYCN was overexpressed. Surprisingly, depletion of SNRPD3 in the presence of overexpressed MYCN further increased differential splicing, particularly of cell cycle regulators, such as BIRC5 and CDK10. MYCN directly bound SNRPD3, and the protein arginine methyltransferase, PRMT5, consequently increasing SNRPD3 methylation. Indeed, the PRMT5 inhibitor, JNJ-64619178, reduced cell viability and SNRPD3 methylation in neuroblastoma cells with high SNRPD3 and MYCN expression. Our findings demonstrate a functional relationship between MYCN and SNRPD3, which maintains the fidelity of MYCN-driven alternative splicing in the narrow range required for neuroblastoma cell growth. SNRPD3 methylation and its protein-protein interface with MYCN represent novel therapeutic targets.
Biological principles for music and mental health
Authors: Bowling Daniel L. 
Published: December 2023

AbstractEfforts to integrate music into healthcare systems and wellness practices are accelerating but the biological foundations supporting these initiatives remain underappreciated. As a result, music-based interventions are often sidelined in medicine. Here, I bring together advances in music research from neuroscience, psychology, and psychiatry to bridge music’s specific foundations in human biology with its specific therapeutic applications. The framework I propose organizes the neurophysiological effects of music around four core elements of human musicality: tonality, rhythm, reward, and sociality. For each, I review key concepts, biological bases, and evidence of clinical benefits. Within this framework, I outline a strategy to increase music’s impact on health based on standardizing treatments and their alignment with individual differences in responsivity to these musical elements. I propose that an integrated biological understanding of human musicality—describing each element’s functional origins, development, phylogeny, and neural bases—is critical to advancing rational applications of music in mental health and wellness.
SOX2 promotes vasculogenic mimicry by accelerating glycolysis via the lncRNA AC005392.2-GLUT1 axis in colorectal cancer
Authors: Huang Shimiao , Wang Xuan , Zhu Yin , Wang Yadong , Chen Jiaxuan , Zheng Haoxuan 
Published: December 2023

AbstractVasculogenic mimicry (VM), a new model of angiogenesis, fulfills the metabolic demands of solid tumors and contributes to tumor aggressiveness. Our previous study demonstrated the effect of SOX2 in promoting VM in colorectal cancer (CRC). However, the underlying mechanisms behind this effect remain elusive. Here, we show that SOX2 overexpression enhanced glycolysis and sustained VM formation via the transcriptional activation of lncRNA AC005392.2. Suppression of either glycolysis or AC005392.2 expression curbed SOX2-driven VM formation in vivo and in vitro. Mechanistically, SOX2 combined with the promoter of AC005392.2, which decreased H3K27me3 enrichment and thus increased its transcriptional activity. Overexpression of AC005392.2 increased the stability of GLUT1 protein by enhancing its SUMOylation, leading to a decrease in the ubiquitination and degradation of GLUT1. Accumulation of GLUT1 contributed to SOX2-mediated glycolysis and VM. Additionally, clinical analyses showed that increased levels of AC005392.2, GLUT1, and EPHA2 expression were positively correlated with SOX2 and were also associated with poor prognoses in patients with CRC. Our study conclusively demonstrates that the SOX2-lncRNA AC005392.2-GLUT1 signaling axis regulates VM formation in CRC, offering a foundation for the development of new antiangiogenic drugs or new drug combination regimens.
Isochronic development of cortical synapses in primates and mice
Authors: Wildenberg Gregg , Li Hanyu , Sampathkumar Vandana , Sorokina Anastasia , Kasthuri Narayanan 
Published: December 2023

AbstractThe neotenous, or delayed, development of primate neurons, particularly human ones, is thought to underlie primate-specific abilities like cognition. We tested whether synaptic development follows suit—would synapses, in absolute time, develop slower in longer-lived, highly cognitive species like non-human primates than in shorter-lived species with less human-like cognitive abilities, e.g., the mouse? Instead, we find that excitatory and inhibitory synapses in the male Mus musculus (mouse) and Rhesus macaque (primate) cortex form at similar rates, at similar times after birth. Primate excitatory and inhibitory synapses and mouse excitatory synapses also prune in such an isochronic fashion. Mouse inhibitory synapses are the lone exception, which are not pruned and instead continuously added throughout life. The monotony of synaptic development clocks across species with disparate lifespans, experiences, and cognitive abilities argues that such programs are likely orchestrated by genetic events rather than experience.
Intracellular tension sensor reveals mechanical anisotropy of the actin cytoskeleton
Authors: Amiri Sorosh , Muresan Camelia , Shang Xingbo , Huet-Calderwood Clotilde , Schwartz Martin A. , Calderwood David A. , Murrell Michael 
Published: December 2023

AbstractThe filamentous actin (F-actin) cytoskeleton is a composite material consisting of cortical actin and bundled F-actin stress fibers, which together mediate the mechanical behaviors of the cell, from cell division to cell migration. However, as mechanical forces are typically measured upon transmission to the extracellular matrix, the internal distribution of forces within the cytoskeleton is unknown. Likewise, how distinct F-actin architectures contribute to the generation and transmission of mechanical forces is unclear. Therefore, we have developed a molecular tension sensor that embeds into the F-actin cytoskeleton. Using this sensor, we measure tension within stress fibers and cortical actin, as the cell is subject to uniaxial stretch. We find that the mechanical response, as measured by FRET, depends on the direction of applied stretch relative to the cell’s axis of alignment. When the cell is aligned parallel to the direction of the stretch, stress fibers and cortical actin both accumulate tension. By contrast, when aligned perpendicular to the direction of stretch, stress fibers relax tension while the cortex accumulates tension, indicating mechanical anisotropy within the cytoskeleton. We further show that myosin inhibition regulates this anisotropy. Thus, the mechanical anisotropy of the cell and the coordination between distinct F-actin architectures vary and depend upon applied load.
Nitric oxide controls shoot meristem activity via regulation of DNA methylation
Authors: Zeng Jian , Zhao Xin’Ai , Liang Zhe , Hidalgo Inés , Gebert Michael , Fan Pengfei , Wenzl Christian , Gornik Sebastian G. , Lohmann Jan U. 
Published: December 2023

AbstractDespite the importance of Nitric Oxide (NO) as signaling molecule in both plant and animal development, the regulatory mechanisms downstream of NO remain largely unclear. Here, we show that NO is involved in Arabidopsis shoot stem cell control via modifying expression and activity of ARGONAUTE 4 (AGO4), a core component of the RNA-directed DNA Methylation (RdDM) pathway. Mutations in components of the RdDM pathway cause meristematic defects, and reduce responses of the stem cell system to NO signaling. Importantly, we find that the stem cell inducing WUSCHEL transcription factor directly interacts with AGO4 in a NO dependent manner, explaining how these two signaling systems may converge to modify DNA methylation patterns. Taken together, our results reveal that NO signaling plays an important role in controlling plant stem cell homeostasis via the regulation of de novo DNA methylation.
Regulation of the cell division hydrolase RipC by the FtsEX system in Mycobacterium tuberculosis
Authors: Li Jianwei , Xu Xin , Shi Jian , Hermoso Juan A. , Sham Lok-To , Luo Min 
Published: December 2023

AbstractThe FtsEX complex regulates, directly or via a protein mediator depending on bacterial genera, peptidoglycan degradation for cell division. In mycobacteria and Gram-positive bacteria, the FtsEX system directly activates peptidoglycan-hydrolases by a mechanism that remains unclear. Here we report our investigation of Mycobacterium tuberculosis FtsEX as a non-canonical regulator with high basal ATPase activity. The cryo-EM structures of the FtsEX system alone and in complex with RipC, as well as the ATP-activated state, unveil detailed information on the signal transduction mechanism, leading to the activation of RipC. Our findings indicate that RipC is recognized through a “Match and Fit” mechanism, resulting in an asymmetric rearrangement of the extracellular domains of FtsX and a unique inclined binding mode of RipC. This study provides insights into the molecular mechanisms of FtsEX and RipC regulation in the context of a critical human pathogen, guiding the design of drugs targeting peptidoglycan remodeling.
Microplastic burden in marine benthic invertebrates depends on species traits and feeding ecology within biogeographical provinces
Authors: Porter Adam , Godbold Jasmin A. , Lewis Ceri N. , Savage Georgie , Solan Martin , Galloway Tamara S. 
Published: December 2023

AbstractThe microplastic body burden of marine animals is often assumed to reflect levels of environmental contamination, yet variations in feeding ecology and regional trait expression could also affect a species’ risk of contaminant uptake. Here, we explore the global inventory of individual microplastic body burden for invertebrate species inhabiting marine sediments across 16 biogeographic provinces. We show that individual microplastic body burden in benthic invertebrates cannot be fully explained by absolute levels of microplastic contamination in the environment, because interspecific differences in behaviour and feeding ecology strongly determine microplastic uptake. Our analyses also indicate a degree of species-specific particle selectivity; likely associated with feeding biology. Highest microplastic burden occurs in the Yellow and Mediterranean Seas and, contrary to expectation, amongst omnivores, predators, and deposit feeders rather than suspension feeding species. Our findings highlight the inadequacy of microplastic uptake risk assessments based on inventories of environmental contamination alone, and the need to understand how species behaviour and trait expression covary with microplastic contamination.