bluuebunny/crossref_metadata_2025_split huggingface dataset:
Pseudo‐Crown Ether‐based Host for the Recognition of Pd2+ and Fe3+ ions in Water
Authors: Kumar Sanjeev , Singh Prabhpreet 
Published: November 2023

AbstractThe development of coordination‐based host for the detection of heavy metal ions in aqueous medium is a challenging task. We report 1,8‐naphthalimide‐based pseudo‐crown ether host which possess hexaethylene glycol chain for the selective binding of Pd2+ and Fe3+ with higher affinity for Pd2+ over Fe3+ ions. The lowest detection limits for Pd2+ and Fe3+ ions are 2.5 nM and 15 nM, respectively. Job's and Hill plot showed 1 : 1 stochiometric complexation between NHG:Mn+ with binding constants of 1.4×104 M−1 (Pd2+) and 1.5×103 M−1 (Fe3+). The CIE plot of NHG showed 90 % blue colour purity in CHCl3 solution. In solid‐state, the CIE plot of NHG showed blue‐green colour with 52.7 % green colour purity and high quantum yield (ϕ=0.0643). The flake‐like aggregates of NHG transformed into spherical structure upon interaction with Pd2+ as confirmed by microscopic and light scattering studies.
Phyto‐synthesized ZnO/ZrO2 binary oxide as a new electro‐catalyst for water splitting application ZnO/ZrO2 for water splitting application
Authors: Zahra Taghazal , Shahzad Ahmad Khuram , Zequine Camila , Gupta Ram K. , Guy Thomas Andrew , Okla Mohammad K. , Saleh Ibrahim A. 
Published: November 2023

AbstractExamining proficient electro‐catalyst from earth abundant and sustainable material is highly required for clean energy generation and a step toward fuel cell. In this study, ZnO/ZrO2 mixed metal oxide has been synthesized using organic chemicals in a straightforward and environmentally friendly manner. The greener routes are not only employed for the synthesis of nano structured material but they also improve the charge transfer properties of material in term of high surface area. The as prepared nano‐oxides were probed for phase structure, morphology, surface chemistry and optical properties by spectroscopic techniques. The embedded phyto‐functionalized compounds in the prepared nano‐material were probed by FTIR and GC–MS demonstrating the phyto‐functionalization of ZnO/ZrO2 nanomaterial. Thereafter, effects of functionalization were observed on the electrochemical behavior of synthesized material. The electrochemical investigation revealed remarkable catalytic activity of fabricated ZnO/ZrO2 with small overpotential and Tafel slope for current density of 10 mA cm−2. Therefore, current work demonstrated the promising electrocatalytic potential of fabricated mixed metal oxide and paved a cost effective and efficient organic template to synthesize binary or ternary mixed oxide with enhanced electrocatalytic properties.
Water‐Assisted Photoinduced Tautomerization in a Potential Bioactive Semicarbazone Schiff Base
Authors: Singh Piyush , Teena Teena , Ganorkar Kapil , Kumar Ghosh Sujit 
Published: November 2023

AbstractThis article epitomizes the design and synthesis of a potential bioactive Semicarbazone Schiff base (E)‐2‐(4‐(diethylamino)‐2‐hydroxybenzylidene)hydrazine‐1‐carboxamide (DHHC) and its water assisted photoinduced tautomerization. DHHC is feebly emissive in non‐polar solvents but the fluorescence intensity intensifies (at 406 nm) in alcohols possibly due to intermolecular H‐bonding. However, in protic polar water, the scenario is markedly different, the fluorescence intensity decreases a bit as compared to alcohols and the emission maxima shifted from 406 nm to 430 nm probably due to solvent (water) assisted excited state proton transfer reaction (ESPT). In contrast to the reported excited state intramolecular proton transfer reaction (ESIPT) in various compounds, DHHC on photoexcitation loses a proton from its phenolic ‐OH group to the water molecule, which insists a subsequent proton transfer from the hydronium ion to the imine nitrogen of DHHC resulting 24 nm red‐shifted fluorescence emission from the tautomeric species of DHHC, in aqueous media. The mechanism of ESPT reaction is explained theoretically through the reaction kinetics of the DHHC‐water complex (in ratio 1 : 3) in an explicit CPCM solvent model. The illustration of the findings may open up enormous possibilities for Semicarbazone Schiff bases to be used as a probe for water sensing inside biomacromolecules like proteins and enzymes.
Pt/γ‐Al2O3 Catalyst for Liquid‐Phase Hydrogen‐Transfer Hydrodechlorination of 4‐Chlorophenol in Alkaline Isopropanol
Authors: Mena Hesham , Perechodjuk Anna , Springer Armin , Wohlrab Sebastian 
Published: November 2023

AbstractThe mild catalytic hydrogen‐transfer hydrodechlorination (HDC) of 4‐chlorophenol (4‐CP) was studied in heterogeneous batch mode. The applied catalyst was prepared by impregnation of γ‐Al2O3 with preformed Pt nanoparticles (1.0 % w/w). Analytical data of both the Pt nanoparticles and the final catalyst are presented. 96.8 % conversion of 4‐chlorophenol was obtained in isopropanol after 24 h at 82 °C and atmospheric pressure in the presence of potassium tert‐butoxide (tBuOK). Phenol was the only reaction product formed and hydrogenation of the aromatic ring did not occur. The Pt/γ‐Al2O3 catalyst was also evaluated under varying reaction conditions (temperature, base, time) and it shows during 5 hydrodechlorination/regeneration cycles only slight deactivation (24 h at 82 °C, X=87.3 % after the fifth cycle).
Green Synthesis of Poly(vinyl alcohol)‐Silver Nanoparticles Composite Using Kendu (Diospyros melanoxylon Roxb) Fruit Peel Extract and Its Antibacterial Activity
Authors: Mohan Kisku Kanta , Mandal Pinaki , Ghosh Samaresh , Sarathi De Partha 
Published: November 2023

AbstractGreenly synthesized silver nanoparticles (AgNPs) are gaining attention as potential antimicrobials. We report on the green method for the synthesis of poly (vinyl alcohol) (PVA) – silver nanoparticles (PVA‐AgNPs) composite 1 using Kendu (Diospyros melanoxylon Roxb) fruit peel (KFP) aqueous extract. The use of KFP extract for the synthesis of AgNPs in the composite has been investigated for the first time. UV−visible spectroscopy and transmission electron microscopy (TEM) are employed to characterize the prepared AgNPs. The FTIR and 1H NMR spectral analyses reveal the involvement of phytochemicals of the KFP extract in the composite synthesis. The composite exhibits strong antibacterial activity against both Gram‐ negative Escherichia coli and Gram‐positive Staphylococcus aureus bacterial pathogens and action increases with AgNPs content.
Imino Phenolic Benzene‐1,3,5‐tricarbohydrazide Conjugate as a AIEgen‐Based Fluorescent Probe for the Detection and Bioimaging of Lipid Droplets in Living Cells**
Authors: Valand Ravinkumar , Pandey Nidhi , Bandaru Sateesh , Sivaiah Areti 
Published: November 2023

AbstractA new aggregation‐induced emission (AIE) based fluorescent probe (L) has been designed and synthesized by integrating the salicylaldehyde into benzene‐tricarbohydrazide via a condensation reaction for the detection and image of neutral lipid droplets in live cells. The single crystal X‐ray diffraction (XRD) structure of L has been established. The L exhibited solvent polarity‐dependent aggregation‐induced enhanced fluorescence emission at 535 nm with a very large Stokes shift ~203 nm in a binary mixture of water and THF (9 : 1, v/v %) and this is further observed by visually under UV light of 365 nm. The microscopy study revealed that L exhibits aggregation properties reflected in their morphological features around 1.12 μm to 1.68 μm particle size in H2O‐THF mixture (9 : 1). The biological applicability of probe (L) for the detection of lipid droplets in L929 live cells has been demonstrated and these results support the potential applications of L in order to use for the lipid droplets related diagnosis.
A New Efficient One‐Pot Three‐Component Synthesis of Diverse Pyrido[1,2‐a]pyrimidines
Authors: Goryaeva Marina V. , Kushch Svetlana O. , Surnina Elena A. , Burgart Yanina V. , Ezhikova Marina A. , Kodess Mikhail I. , Slepukhin Pavel A. , Saloutin Victor I. 
Published: November 2023

AbstractThe pyrido[1,2‐a]pyrimidine scaffold has great potential for the creation of bioactive substances. Here we propose a simple, cost‐effective, efficient approach to forming this core based on a one‐pot three‐component reaction of commercially available 3‐oxo esters, α,β‐unsaturated aldehydes and 1,3‐diaminopropane. The developed strategy makes it possible to obtain diverse pyrido[1,2‐a]pyrimidines thanks to alternative intramolecular cyclization pathways that depend on the substituent in the 3‐oxo ester. Their diastereomeric structure was determined using NMR spectroscopy and XRD. A mechanism for the formation of new pyrido[1,2‐a]pyridines has been proposed.
Synthesis of Sulfonic Acid Salts and Sulfonic Acids by Advanced Cross‐Coupling Reaction of Vinyl Sulfonates
Authors: Koudelka Jakub , Vosmanská Magda , Tobrman Tomáš 
Published: November 2023

AbstractThe present work describes an advanced cross‐coupling reaction of vinyl sulfonates for the synthesis of sulfonic acid salts and sulfonic acids under mild reaction conditions. The regioselectivity of the double Negishi reaction was achieved by means of the different reactivity of the C−Br and activated C−O bonds. The cross‐coupling reaction leads to a mixture of alkenes and sulfonic acid salts. The separation of alkenes and sulfonic acid salts is achieved through the low solubility of sulfonic acid sodium salts after workup. In addition, the developed procedure is also used for the atom‐economical preparation of cyclooxygenase‐2 inhibitors (COX‐2).
High Thermal Stability and Low Thermal Resistance of Large Area GaN/3C‐SiC/Diamond Junctions for Practical Device Processes
Authors: Kagawa Ryo , Cheng Zhe , Kawamura Keisuke , Ohno Yutaka , Moriyama Chiharu , Sakaida Yoshiki , Ouchi Sumito , Uratani Hiroki , Inoue Koji , Nagai Yasuyoshi , Shigekawa Naoteru , Liang Jianbo 
Published: November 2023

AbstractThermal management is critical in contemporary electronic systems, and integrating diamond with semiconductors offers the most promising solution to improve heat dissipation. However, developing a technique that can fully exploit the high thermal conductivity of diamond, withstand high‐temperature annealing processes, and enable mass production is a significant challenge. In this study, the successful transfer of AlGaN/GaN/3C‐SiC layers grown on Si to a large‐size diamond substrate is demonstrated, followed by the fabrication of GaN high electron mobility transistors (HEMTs) on the diamond. Notably, no exfoliation of 3C‐SiC/diamond bonding interfaces is observed even after annealing at 1100 °C, which is essential for high‐quality GaN crystal growth on the diamond. The thermal boundary conductance of the 3C‐SiC‐diamond interface reaches ≈55 MW m−2 K−1, which is efficient for device cooling. GaN HEMTs fabricated on the diamond substrate exhibit the highest maximum drain current and the lowest surface temperature compared to those on Si and SiC substrates. Furthermore, the device thermal resistance of GaN HEMTs on the diamond substrate is significantly reduced compared to those on SiC substrates. These results indicate that the GaN/3C‐SiC on diamond technique has the potential to revolutionize the development of power and radio‐frequency electronics with improved thermal management capabilities.
2D Nanomaterials and Their Drug Conjugates for Phototherapy and Magnetic Hyperthermia Therapy of Cancer and Infections
Authors: Silva Filipa A. L. S. , Chang Hui‐Ping , Incorvia Jean Anne C. , Oliveira Maria J. , Sarmento Bruno , Santos Susana G. , Magalhães Fernão D. , Pinto Artur M. 
Published: November 2023

AbstractPhotothermal therapy (PTT) and magnetic hyperthermia therapy (MHT) using 2D nanomaterials (2DnMat) have recently emerged as promising alternative treatments for cancer and bacterial infections, both important global health challenges. The present review intends to provide not only a comprehensive overview, but also an integrative approach of the state‐of‐the‐art knowledge on 2DnMat for PTT and MHT of cancer and infections. High surface area, high extinction coefficient in near‐infra‐red (NIR) region, responsiveness to external stimuli like magnetic fields, and the endless possibilities of surface functionalization, make 2DnMat ideal platforms for PTT and MHT. Most of these materials are biocompatible with mammalian cells, presenting some cytotoxicity against bacteria. However, each material must be comprehensively characterized physiochemically and biologically, since small variations can have significant biological impact. Highly efficient and selective in vitro and in vivo PTTs for the treatment of cancer and infections are reported, using a wide range of 2DnMat concentrations and incubation times. MHT is described to be more effective against bacterial infections than against cancer therapy. Despite the promising results attained, some challenges remain, such as improving 2DnMat conjugation with drugs, understanding their in vivo biodegradation, and refining the evaluation criteria to measure PTT or MHT effects.
Hierarchically Superstructured Anisotropic Carbon Particles by Multiscale Assembly Driven by Spinodal Decomposition
Authors: Ban Minkyeong , Lee Jisung , Kim Jioh , Shin Seung‐Jae , Kim Taesoo , Jo Changshin , Hwang Jongkook , Kim Seongseop , Lee Jinwoo 
Published: November 2023

AbstractHierarchical superstructures have novel shape‐dependent properties, but well‐defined anisotropic carbon superstructures with controllable size, shape, and building block dimensionality have rarely been accomplished thus far. Here, a hierarchical assembly technique is presented that uses spinodal decomposition (SD) to synthesize anisotropic oblate particles of mesoporous carbon superstructure (o‐MCS) with nanorod arrays by integrating block‐copolymer (BCP) self‐assembly and polymer‐polymer interface behaviors in binary blends. The interaction of major and minor phases in binary polymer blends leads to the formation of an anisotropic oblate particle, and the BCP‐rich phase enables ordered packing and unidirectional alignment of carbon nanorods. Consequently, this approach enables precise control over particles’ size, shape, and over the dimensionality of their components. Exploiting this functional superstructure, o‐MCS are used as an anode material in potassium‐ion batteries, and achieve a notable specific capacity of 156 mA h g−1 at a current density of 2 A g−1, and long‐term stability for 3000 cycles. This work presents a significant advancement in the field of hierarchical superstructures, providing a promising strategy for the design and synthesis of anisotropic carbon materials with controlled properties, offering promising applications in energy storage and beyond.
Triblock Proteins with Weakly Dimerizing Terminal Blocks and an Intrinsically Disordered Region for Rational Design of Condensate Properties
Authors: Fedorov Dmitrii , Roas‐Escalona Nelmary , Tolmachev Dmitry , Harmat Adam L. , Scacchi Alberto , Sammalkorpi Maria , Aranko A. Sesilja , Linder Markus B. 
Published: November 2023

AbstractCondensates are molecular assemblies that are formed through liquid–liquid phase separation and play important roles in many biological processes. The rational design of condensate formation and their properties is central to applications, such as biosynthetic materials, synthetic biology, and for understanding cell biology. Protein engineering is used to make a triblock structure with varying terminal blocks of folded proteins on both sides of an intrinsically disordered mid‐region. Dissociation constants are determined in the range of micromolar to millimolar for a set of proteins suitable for use as terminal blocks. Varying the weak dimerization of terminal blocks leads to an adjustable tendency for condensate formation while keeping the intrinsically disordered region constant. The dissociation constants of the terminal domains correlate directly with the tendency to undergo liquid–liquid phase separation. Differences in physical properties, such as diffusion rate are not directly correlated with the strength of dimerization but can be understood from the properties and interplay of the constituent blocks. The work demonstrates the importance of weak interactions in condensate formation and shows a principle for protein design that will help in fabricating functional condensates in a predictable and rational way.
Heterostructured Co‐Doped‐Cu2O/Cu Synergistically Promotes Water Dissociation for Improved Electrochemical Nitrate Reduction to Ammonia
Authors: Qu Yanbin , Dai Tianyi , Cui Yuhuan , Ding Guopeng , Zhu Yongfu , Wang Zhili , Jiang Qing 
Published: November 2023

AbstractElectrochemical nitrate reduction reaction (NO3RR) has recently emerged as a promising approach for sustainable ammonia synthesis and wastewater treatment, while the activity and selectivity for ammonia production have remained low. Herein, rational design and controllable synthesis of heterostructured Co‐doped Cu2O/Cu nanoparticles embedded in carbon framework (Co‐Cu2O/Cu@C) is reported for NO3RR. The Co‐Cu2O/Cu@C exhibits a high ammonia yield rate of 37.86 mg h−1 mg−1cat. with 98.1% Faraday efficiency, which is higher than those obtained for most of the Cu‐based catalysts under similar conditions. Density functional theory calculations indicated that the strong electronic interactions at Cu/Co‐Cu2O interface facilitate the N species deoxygenation process and doping of Co promotes water dissociation to generate *H for the N species hydrogenation process, leading to enhanced NO3RR performance. This work provides a new design strategy toward high‐performance catalysts toward NO3RR for ammonia generation.
Stability indicating high‐performance liquid chromatography method for determining doxycycline hyclate and related substances in their various dosage forms: Utilizing Six Sigma tools, uniformity testing, and in‐vitro dissolution approaches
Authors: Mahmoud Osama A. , Omran Ahmed A. , Gomaa Hosni A. , Mohamed Mahmoud A. 
Published: November 2023

AbstractDoxycycline hyclate (DOXH) is very important to treat acne and prevent infections caused by bacteria, so quantifying doxycycline hyclate and its related substances is crucial. In this work, All analytes of doxycycline and its related substances, including methacycline, 4‐epi doxycycline, 6‐epi doxycycline, and 2‐acetyl‐2‐carbamoyl doxycycline, were successfully separated at low concentrations in a single run utilizing the suggested isocratic high‐performance liquid chromatography method with a mobile phase comprising water:acetonitrile:perchloric acid (75:25:0.2, v/v), Phenomenex Luna C18 column (50 × 4.6 mm, 3 μm i.d.) maintained at 30°C with a flow rate of 0.7 mL/min, injection volume of 25 μL, and photodiode array detector at 269 nm. DOXH and its related substances were linear in the range of 0.25–50, 0.1–30, 0.2–35, 0.5–50, and 0.6–20 μg/mL, respectively, with correlation coefficients greater than 0.999 and good accuracy results between 98% and 102%. The method has been successfully used to determine the drug's comparative study in both generic and reference products, demonstrating the similarity between the two products. According to the International Council for Harmonization requirements, the proposed approach was validated. Additionally, the technique has effectively studied in vitro dissolution, Six Sigma, and content uniformity.
“I'll be there for you”: A review of research on beneficial dissertation mentoring practices
Authors: Major Claire Howell 
Published: November 2023

AbstractMany doctoral students fail to finish their degrees, often stopping out at the dissertation stage. This article reviews successful dissertation mentoring practices, focusing on mentors' roles in aiding the completion of these degrees. Drawing on Kram's mentoring support framework—psychosocial and career/instrumental factors—the review employs qualitative meta‐synthesis to integrate qualitative research findings. The synthesis reveals that successful dissertation mentorship hinges on mentors' expertise, passion, care, and representation. Key findings underscore the value of trust‐building, setting high expectations, nurturing professional relationships, mutual respect, and encouragement. Moreover, career and instrumental support are crucial, encompassing accessibility, guidance, coaching, resource provisioning, modeling, feedback, and advocacy. The study highlights the alignment of effective dissertation mentorship with Kram's framework, spanning psychosocial and career/instrumental dimensions. It underscores the significance of tailored mentorship in facilitating doctoral students' successful dissertation completion and overall academic achievement.
Fibrodysplasia ossificans progressiva caused by a different mutation in a stray cat
Authors: İlgün Murat , Yanar Kerim Emre , Özdemir Selçuk , Aktaş Mustafa Sinan , Eren Emre 
Published: November 2023

AbstractA 2‐year‐old, unneutered, female, short‐haired stray cat was referred for general examination. A physical examination revealed gait abnormalities characterised by short strides and stiffness in all limbs. Radiographs showed malformations with excessive mineralisation affecting the shoulders and stifle joints. To confirm the diagnosis of fibrodysplasia ossificans progressiva, total RNA was isolated from blood samples of the cats (one cat with fibrodysplasia ossificans progressiva and one healthy cat). A single missense mutation was found in the coding sequence of the ACVR1 gene of the cat with fibrodysplasia ossificans progressiva. In this mutation, a single base was changed from guanine to cytosine. After this base change, the amino acid tryptophan replaced the amino acid cysteine. This is the first report that indicates cats with fibrodysplasia ossificans progressiva that do not show signs similar to the characteristic findings in humans have a different mutation.
Opening the Higgs portal to lepton-flavoured dark matter
Authors: Acaroğlu Harun , Blanke Monika , Tabet Mustafa 
Published: November 2023

Abstract
We study a simplified model of lepton-flavoured complex scalar dark matter coupling to right-handed leptons and the Higgs boson. The model is set up in the Dark Minimal Flavour Violation framework. In contrast to previous studies of similar models we consider the most general case and do not a priori constrain the hierarchy of dark matter masses and couplings in any way aside from the chosen parameter ranges. In the first part of the analysis we discuss the impact of Higgs portal interactions and the generalised mass hierarchy on the model’s phenomenology. We find that they render new physics masses around the electroweak scale viable, thus qualifying this model to address the (g − 2)μ puzzle. After reviewing the current situation of the latter, we perform two combined analyses — one in which (g − 2)μ allows for significant new physics effects and one in which it does not. We find that while the latter scenario allows for a larger range of new physics scales, both scenarios are equally viable.