bluuebunny/crossref_metadata_2025_split huggingface dataset:
The challenges of research data management in cardiovascular science: a DGK and DZHK position paper—executive summary
Authors: Steffens Sabine , Schröder Katrin , Krüger Martina , Maack Christoph , Streckfuss-Bömeke Katrin , Backs Johannes , Backofen Rolf , Baeßler Bettina , Devaux Yvan , Gilsbach Ralf , Heijman Jordi , Knaus Jochen , Kramann Rafael , Linz Dominik , Lister Allyson L. , Maatz Henrike , Maegdefessel Lars , Mayr Manuel , Meder Benjamin , Nussbeck Sara Y. , Rog-Zielinska Eva A. , Schulz Marcel H. , Sickmann Albert , Yigit Gökhan , Kohl Peter 
Published: October 2023

AbstractThe sharing and documentation of cardiovascular research data are essential for efficient use and reuse of data, thereby aiding scientific transparency, accelerating the progress of cardiovascular research and healthcare, and contributing to the reproducibility of research results. However, challenges remain. This position paper, written on behalf of and approved by the German Cardiac Society and German Centre for Cardiovascular Research, summarizes our current understanding of the challenges in cardiovascular research data management (RDM). These challenges include lack of time, awareness, incentives, and funding for implementing effective RDM; lack of standardization in RDM processes; a need to better identify meaningful and actionable data among the increasing volume and complexity of data being acquired; and a lack of understanding of the legal aspects of data sharing. While several tools exist to increase the degree to which data are findable, accessible, interoperable, and reusable (FAIR), more work is needed to lower the threshold for effective RDM not just in cardiovascular research but in all biomedical research, with data sharing and reuse being factored in at every stage of the scientific process. A culture of open science with FAIR research data should be fostered through education and training of early-career and established research professionals. Ultimately, FAIR RDM requires permanent, long-term effort at all levels. If outcomes can be shown to be superior and to promote better (and better value) science, modern RDM will make a positive difference to cardiovascular science and practice. The full position paper is available in the supplementary materials.
Electrochemistry in sensing of molecular interactions of proteins and their behavior in an electric field
Authors: Vacek Jan , Zatloukalová Martina , Dorčák Vlastimil , Cifra Michal , Futera Zdeněk , Ostatná Veronika 
Published: October 2023

AbstractElectrochemical methods can be used not only for the sensitive analysis of proteins but also for deeper research into their structure, transport functions (transfer of electrons and protons), and sensing their interactions with soft and solid surfaces. Last but not least, electrochemical tools are useful for investigating the effect of an electric field on protein structure, the direct application of electrochemical methods for controlling protein function, or the micromanipulation of supramolecular protein structures. There are many experimental arrangements (modalities), from the classic configuration that works with an electrochemical cell to miniaturized electrochemical sensors and microchip platforms. The support of computational chemistry methods which appropriately complement the interpretation framework of experimental results is also important. This text describes recent directions in electrochemical methods for the determination of proteins and briefly summarizes available methodologies for the selective labeling of proteins using redox-active probes. Attention is also paid to the theoretical aspects of electron transport and the effect of an external electric field on the structure of selected proteins. Instead of providing a comprehensive overview, we aim to highlight areas of interest that have not been summarized recently, but, at the same time, represent current trends in the field.
Graphical abstract
Nano-topographical surface engineering for enhancing bioactivity of PEEK implants (in vitro—histomorphometric study)
Authors: Mostafa Dawlat , Kassem Youssef M. , Omar Samia Soliman , Shalaby Yousreya 
Published: October 2023

Abstract
Objectives
Dental implants are currently becoming a routine treatment decision in dentistry. Synthetic polyetheretherketone (PEEK) polymer is a prevalent component of dental implantology field. The current study aimed to assess the influence of Nd:YAG laser nano-topographical surface engineering combined with ultraviolet light or platelet rich fibrin on the bioactivity and osseointegration of PEEK implants in laboratory and animal testing model.

Materials and methods
Computer Aided Design-Computer Aided Manufacturing (CAD CAM) discs of PEEK were used to fabricate PEEK discs (8 mm × 3 mm) N = 36 and implant cylinders (3 mm × 6 mm) N = 72. Specimens were exposed to Nd:YAG laser at wavelength 1064 nm, and surface roughness topography/Ra parameter was recorded in nanometer using atomic force microscopy. Laser modified specimens were divided into three groups: Nd:YAG laser engineered surfaces (control), Nd:YAG laser/UV engineered surfaces and Nd:YAG laser/PRF engineered surfaces (N = 12 discs–N = 24 implants). In vitro bioactivity test was performed, and precipitated apatite minerals were assessed with X-ray diffraction analysis (XRD) and scanning electron microscopy (SEM). In vivo histomorphometric analysis was performed in rabbits with BIC% calculation.

Results
Ra mean value of PEEK laser engineered surfaces was 125.179 nm. For the studied groups, XRD patterns revealed distinctive peaks of different apatite minerals that were demonstrated by SEM as dispersed surface aggregations. There was a significant increase in the BIC% from control group 56.43 (0.97) to laser/UV surfaces 77.30 (0.78) to laser/PRF 84.80 (1.29) (< 0.0001).

Conclusions
Successful engineered nano-topographical biomimetic PEEK implant could be achieved by Nd:YAG laser technique associated with improving bioactivity. The combination with UV or PRF could be simple and economic methods to gain more significant improvement of PEEK implant surface bioactivity with superior osteointegration.
The German Environmental Tax Reform: a difference-in-differences analysis of its impacts in European comparison
Authors: Kühnhenrich Daniel 
Published: October 2023

AbstractIn 1998, the red-green Schröder government implemented the Environmental Tax Reform (ETR), raising taxes on petrol, diesel, natural gas and heating oil and introducing a new duty on electricity in Germany. At the same time, it cut non-wage labour costs by reducing public pension contributions. The goal was to achieve Germany’s Kyoto Protocol emissions targets and to reduce a level of unemployment unprecedented since World War II while avoiding the burden on the public budget through revenue recycling. Employing microdata from household budget surveys of 1998 and 2003, this article analyses whether increased duties on motor fuels and electricity lead to a substantial reduction in households’ consumption of these goods. Considering the ETR as a natural experiment, it uses the difference-in-differences approach in a European context with Germany as the treatment group and Italy, Spain and the UK as the control group. Ordinary least square regressions reveal that motor fuel demand is price inelastic, while electricity consumption increased despite the substantial rise in prices. Quartile regressions show that the effect of the motor fuel tax is slightly higher at the bottom than at the upper tail of the distribution supporting the notion that low-level consumers are more likely to find alternative substitutes.
Nationwide analysis of open groin hernia repairs in Italy from 2015 to 2020
Authors: Ortenzi M. , Botteri E. , Balla A. , Podda M. , Montori G. , Sartori A. 
Published: October 2023

Abstract
Introduction
Inguinal hernia repair is one of the most commonly performed operations in general surgery. A total of 130.000 inguinal hernia repairs are performed yearly in Italy, and approximately 20 million inguinal hernias are treated worldwide annually. This report represents the trend analysis in inguinal hernia repair in Italy from a nationwide dataset for the 6-year period from 2015 to 2020.

Materials and methods
Based on regional hospital discharge records, all the inguinal hernia repairs performed in public and private hospitals in Italy between 2015 and 2020 were reviewed based on diagnosis and procedure codes. For the aim of this study, data from the AgeNas (The National Agency for Regional Health Services) data source were analyzed.

Results
Elective inguinal hernia repairs outnumbered urgent operations over the 6-year study period, ranging from 122,737 operations in 2015 to 65,780 in 2020 as absolute numbers, and from 87.96 to 83.3% of total procedures in 2019 and 2020 respectively, with an annual change ranging from − 66.58%, between 2020 and 2019, to − 2.49%, between 2019 and 2018 (mean = − 18.74%; CI =− 46.7%–9.22%; p < 0.0001).

Conclusions
This large-scale review of groin hernia data from a nationwide Italian dataset provides a unique opportunity to obtain a snapshot of open groin hernia repair activity. More specifically, there is a trend to perform more elective than urgent procedures and there is a steady decrease in the amount of open hernia repairs in favor to laparoscopy.
An innovative mixed reality approach for maxillofacial osteotomies and repositioning
Authors: Brunzini Agnese , Mazzoli Alida , Pagnoni Mario , Mandolini Marco 
Published: October 2023

AbstractCraniomaxillofacial surgeries are performed using custom-made physical cutting guides and resin dental splints that present several drawbacks (e.g. time and cost required for their design and production). The literature commonly provides augmented/mixed reality (AR/MR) solutions for assisting maxillofacial osteotomies and repositioning without any interactive guide. This work proposes a new MR application, useful for osteotomy and repositioning, providing interactive, fast, and intuitive feedback to the surgeon, who is then supported in performing the bone fragment resection and replacement frame by frame. The proposed application speeds up the surgery and reduces under/overshooting errors. Moreover, the idea of integrating osteotomy and repositioning assistance in the same MR application is rarely found in the literature. It is an entirely novel approach to craniomaxillofacial surgery. The MR application has been designed with a three-button menu. The “App Start” calibrates the app, the “Osteotomy Mode” visualises the holograms of the cutting lines and drilling points, and the “Repositioning Mode” visualises the step-by-step real-time feedback to precisely support the surgeon placing the osteotomised bone fragment towards the final pre-planned position. The MR app has been developed in Unity and deployed on Microsoft HoloLens V2. A laboratory test bench was realised to validate the accuracy of the proposed MR-based approach. The validation protocol consists of two tasks to test the osteotomy and repositioning modes using a 3D-printed skull phantom. For osteotomy, the accuracy is 0.89 mm (genioplasty), 1.24 mm (maxillary osteotomy), 1.33 mm (orthognathic surgery), and 2.89 mm (mandibular angle osteotomy). For repositioning, the accuracy is 0.6 mm (anteroposterior deviation), 0.7 mm (mediolateral deviation), and 0.6° (angular deviation).
Working memory during spontaneous migraine attacks: an fMRI study
Authors: Ruiz-Tagle Amparo , Figueiredo Patrícia , Pinto Joana , Vilela Pedro , Martins Isabel Pavão , Gil-Gouveia Raquel 
Published: October 2023

Abstract
Objective
To investigate the neural correlates of working memory during a spontaneous migraine attack compared to the interictal phase, using functional magnetic resonance imaging (fMRI).

Background
Cognitive disturbances are commonly observed during migraine attacks, particularly in the headache phase. However, the neural basis of these changes remains unknown.

Methods
In a fMRI within-subject test-retest design study, eleven women (32 years of age, average) with episodic migraine were evaluated twice, first during a spontaneous migraine attack, and again in a pain-free period. Each session consisted in a cognitive assessment and fMRI while performing a working memory task (N-back).

Results
Cognitive test scores were lower during the ictal session than in the pain-free session. Regions typically associated with working memory were activated during the N-back task in both sessions. A voxel wise between session comparison showed significantly greater activation in the left frontal pole and orbitofrontal cortex during the attack relative to the interictal phase.

Conclusion
Migraine patients exhibited greater activation of the left frontal pole and orbitofrontal cortex while executing a verbal working memory task during a spontaneous migraine attack when compared to the interictal state. Given the association of these regions with pain processing and inhibitory control, these findings suggest that patients recruit inhibitory areas to accomplish the cognitive task during migraine attacks, a neural signature of their cognitive difficulties.
Connected coordinated motion planning with bounded stretch
Authors: Fekete Sándor P. , Keldenich Phillip , Kosfeld Ramin , Rieck Christian , Scheffer Christian 
Published: October 2023

AbstractWe consider the problem of connected coordinated motion planning for a large collective of simple, identical robots: From a given start grid configuration of robots, we need to reach a desired target configuration via a sequence of parallel, collision-free robot motions, such that the set of robots induces a connected grid graph at all integer times. The objective is to minimize the makespan of the motion schedule, i.e., to reach the new configuration in a minimum amount of time. We show that this problem is -complete, even for deciding whether a makespan of 2 can be achieved, while it is possible to check in polynomial time whether a makespan of 1 can be achieved. On the algorithmic side, we establish simultaneous constant-factor approximation for two fundamental parameters, by achieving constant stretch for constant scale. Scaled shapes (which arise by increasing all dimensions of a given object by the same multiplicative factor) have been considered in previous seminal work on self-assembly, often with unbounded or logarithmic scale factors; we provide methods for a generalized scale factor, bounded by a constant. Moreover, our algorithm achieves a constant stretch factor: If mapping the start configuration to the target configuration requires a maximum Manhattan distance of d, then the total duration of our overall schedule is $$\mathcal {O}(d)$$

O
(
d
)

, which is optimal up to constant factors.
On the Personal, Intersubjective, and Metaphysical Senses of Death: An Inquiry into Edmund Husserl’s Transcendental Phenomenological Approach to Death
Authors: Toronyai Gábor 
Published: October 2023

AbstractIn this short study, I attempt to reconstruct the main conceptual components of Edmund Husserl’s concept of death following the leading clue of his late transcendental phenomenological methodology. First, I summarise his thoughts on death, from the point of view of “the natural attitude”, as an event in the world. Then, I try and explore the manifold senses of the limit phenomenon of death as a multidimensional transcendental phenomenological problem in all of its intersubjective-world constitutive, personal-primordial, and metaphysical-constructive layers of meanings, respectively. By doing so, I also hope that the path we travel can serve the reader as an opportunity for a personal and reflective confrontation with death.
Sesamol defends neuronal damage following cerebral ischemia/reperfusion: a crosstalk of autophagy and Notch1/NLRP3 inflammasome signaling
Authors: El-Sayyad Shorouk Mohamed , El-Ella Dina M. Abo , Hafez Mohamed M. , Al-Mokaddem Asmaa K. , Ali Bassam Mohamed , Awny Magdy M. , El-Emam Soad Z. 
Published: October 2023

Abstract
Objective
Sesamol (SES) is a phenolic compound found in sesame seed oil. Several studies have revealed its anti-inflammatory and antioxidant properties. However, its complete underlying mechanistic perspective about cerebral ischemia/reperfusion (I/R) lesions has not yet been disclosed. Consequently, we aimed to scrutinize its neuroprotective mechanism against cerebral injury during a global cerebral I/R in a rat model, considering its impact on autophagy and Notch1/NLRP3 inflammasome signaling regulation.

Methods
To affirm our purpose, adult Wistar rats were allotted into five groups: sham and the other four groups in which transient global cerebral ischemia was induced by bilateral common ligation (2VO) for 1 h, then reperfusion for either 24 h or 5 days: I/R (1/24), I/R (1/5), SES + I/R (1/24), and SES + I/R (1/5). In treated groups, SES (100 mg/kg, p.o., for 21 days) was administered before cerebral I/R induction. The assessment of histopathological changes in brain tissues, immunohistochemistry, biochemical assays, ELISA, and qRT-PCR were utilized to investigate our hypothesis.

Results
Advantageously, SES halted the structural neuronal damage with lessened demyelination induced by cerebral I/R injury. Restoring oxidant/antioxidant balance was evident by boosting the total antioxidant capacity and waning lipid peroxidation. Furthermore, SES reduced inflammatory and apoptosis markers. Additionally, SES recovered GFAP, Cx43, and autophagy signaling, which in turn switched off the Notch-1/NLRP3 inflammasome trajectory.

Conclusions
Our results revealed the neuroprotective effect of SES against cerebral I/R injury through alleviating injurious events and boosting autophagy, consequently abolishing Notch1/NLRP3 inflammasome signaling.
The popularity function: a spurious regression? The case of Austria
Authors: Neck Reinhard , Schneider Friedrich 
Published: October 2023

AbstractIn this paper we apply the unit root and cointegration methodology as well as other methods of modern econometric time series analysis to estimate popularity functions for the Austrian parties in power since the mid-1970s. We find only very rare evidence for economic variables influencing the popularity of the main political parties in the federal government, thereby challenging previous studies that claimed to have established such influences. When considering the determinants of the popularity of the incumbent party (the sum of the popularities of the parties in government), the unemployment rate turns out to have a negative short-run influence. The robustness of this result is checked by various methods, demonstrating the usefulness of the applied methodology to clarify such issues.
TV Series in Mainstream Media Depicting Autism and Self-Diagnosis of Autism in a General Population of Young Adults
Authors: Mittmann Gloria , Schrank Beate , Steiner-Hofbauer Verena 
Published: October 2023

Abstract
Purpose
The prevalence of autism diagnoses has increased in recent years. The portrayal of autistic characters in mainstream media, such as TV series, may be a contributing factor. This study investigated whether young adults who consume media featuring autistic characters are more likely to self-diagnose with autism.

Methods
348 participants filled out an online questionnaire exploring their media consumption, subjective diagnosis of autism and objective indicators of autism using an Emotion Recognition Task.

Results
Results from linear regression analysis indicated a significant correlation between media consumption and self-diagnosis, while valence of the series and objective diagnosis did not have a significant influence. The study found no gender differences.

Conclusion
The results suggest a need for further research on the relationship between media consumption and self-diagnosis, including for other forms of media beyond TV series.
Quantifying Spatial Complexity of Settlement Plans Through Fractal Analysis
Authors: Bruvoll Hallvard 
Published: October 2023

AbstractIn this paper, I investigate the possibilities and limitations of fractal analysis methods applied to archaeological and synthetic settlement plans, with the goal of providing quantitative measures of spatial randomness or noise, as well as potential tools for automated culture-historical attribution of settlement plans and socio-economic intra-site differentiation. The archaeological sample is made from Linear Pottery settlements in south-west Slovakia and Trypillia settlements in the Southern Bug—Dnieper interfluve in central Ukraine, all based upon high-quality geomagnetic site plans. Synthetic plans are constructed as geometrically ideal versions of the archaeological ones, with varying degrees of added spatial noise. A significant correlation between fractal dimension and noise level is revealed for synthetic settlement plans, independently of size, density, house-size distribution and basic layout. However, several methodological challenges persist, and further systematic exploration on larger samples is needed before these results may be generalised. All analysis is performed in the R language and the script is made freely available in order to facilitate further development.
Prospective approaches to gene therapy computational modeling – spotlight on viral gene therapy
Authors: Choules Mary P , Bonate Peter L. , Heo Nakyo , Weddell Jared 
Published: October 2023

AbstractClinical studies have found there still exists a lack of gene therapy dose-toxicity and dose-efficacy data that causes gene therapy dose selection to remain elusive. Model informed drug development (MIDD) has become a standard tool implemented throughout the discovery, development, and approval of pharmaceutical therapies, and has the potential to inform dose-toxicity and dose-efficacy relationships to support gene therapy dose selection. Despite this potential, MIDD approaches for gene therapy remain immature and require standardization to be useful for gene therapy clinical programs. With the goal to advance MIDD approaches for gene therapy, in this review we first provide an overview of gene therapy types and how they differ from a bioanalytical, formulation, route of administration, and regulatory standpoint. With this biological and regulatory background, we propose how MIDD can be advanced for AAV-based gene therapies by utilizing physiological based pharmacokinetic modeling and quantitative systems pharmacology to holistically inform AAV and target protein dynamics following dosing. We discuss how this proposed model, allowing for in-depth exploration of AAV pharmacology, could be the key the field needs to treat these unmet disease populations.