bluuebunny/crossref_metadata_2025_split huggingface dataset:
An extensive arterial thrombosis with lower limb ischemia in a COVID‐19 patient: A case report
Authors: Andriamizanaka Johary Andriamamonjisoa , Rakotomijoro Etienne , Andriananja Volatiana , Raberahona Mihaja , Andrianasolo Radonirina Lazasoa , Rakotoarivelo Rivonirina Andry , de Dieu Randria Mamy Jean 
Published: November 2023

Key Clinical MessageThe coronavirus disease 2019 (COVID‐19) pandemic is responsible for huge morbidity and mortality throughout the world. Several serious complications of this disease have been reported. It can cause hypercoagulability, which may lead to venous and arterial thromboembolic diseases. This hypercoagulability state is also associated with high morbidity and mortality. Arterial thrombosis in COVID‐19 is poorly described compared to venous thrombosis and pulmonary embolism. We report a case of an extensive arterial thrombosis leading to a limb ischemia with extremely high D‐dimer in a COVID‐19 patient. A 69‐year‐old man was hospitalized for febrile dyspnea. He is a hypertensive and diabetic patient. On admission, pulse oxygen saturation was 72% on room air. He had cyanosis of the left foot up to the mid‐thigh. The left pedal, posterior tibial, popliteal and femoral pulses were abolished. Chest CT scan was in favor of COVID‐19. He has a high D‐dimer level of 257,344 ng/mL. Arterial Echo‐Doppler found an extensive intraluminal thrombus along the arterial axes of the left lower limb, completely obstructing them, starting from the primitive iliac artery just after its bifurcation with the aorta, and extending distally (external iliac; common femoral; superficial femoral; popliteal; anterior tibial; posterior tibial; fibular and pedal). The patient was diagnosed with COVID‐19 critical form, associated with ischemia of the left lower limb secondary to an extensive arterial thrombosis. He was receiving anticoagulation, and underwent surgical amputation of the ischemic limb. The patient survived the event; however, he was on long‐term oxygen therapy at home. Arterial thrombosis may occur during COVID‐19 and may be responsible for peripheral or central ischemia aggravating morbidity and mortality. The occurrence of these events is related to the D‐dimer value. Anticoagulation is an important part of the management of COVID‐19, especially in severe forms in order to limit the occurrence of these thromboembolic diseases.
Uremic encephalopathy manifesting with a unique MRI finding (the lentiform fork sign) in an adult male: A case report
Authors: Alhusseini Ayham , Hamsho Suaad , Alabdullah Hadi , Alaswad Mohammed , Sleiay Mouhammed , Alsamarrai Omar 
Published: November 2023

Key Clinical MessageA novel radiologic sign in patients with renal failure and uremic encephalopathy (UE) with metabolic acidosis has recently been identified as the lentiform fork sign. On magnetic resonance imaging (MRI), the “lentiform fork sign” has been described as bilateral symmetrical hyperintensities in the basal ganglia encircled by a hyperintese rim delineating the lentiform nucleus. Changes in uremic solute retention, aberrant blood–brain barrier transport, disordered vascular reactivity, altered electrolyte and acid–base balance, and altered hormone metabolism are the most likely causes of the condition. A 56‐year‐old male with end‐stage renal disease was brought to the emergency room for a progressive change in mental status and involuntary arm movements over the previous 5 days, which were accompanied by mild dyspnea. A brain MRI was performed, and it revealed hyperintensity on T2/FLAIR in the white matter surrounding the basal ganglia. the patient was treated with dialysis and improved greatly. Intensified hemodialysis and glycemic control are the cornerstones of treating diabetic uremic syndrome (DUS) with likely reversible clinical symptoms and remission of imaging abnormalities.
A rare cause of posterior reversible encephalopathy syndrome: Acute lymphoblastic leukemia
Authors: Hayes Jessica , Mahoney Anne Byrd , Ayers Claci , Sarma Asha , Ess Kevin C. , Hunley Tracy E. , Smith Christine Moore 
Published: November 2023

Key Clinical MessageThe presentation of posterior reversible encephalopathy syndrome (PRES) as the initial presenting sign of acute lymphoblastic leukemia is unusual, as PRES is more often a complication of therapy. This case highlights the importance of maintaining a broad differential diagnosis for pediatric hypertension and its complications.AbstractA 6‐year‐old male presented with a seizure‐like episode. Evaluation revealed hypertension and brain imaging showed findings consistent with posterior reversible encephalopathy syndrome. Complete blood count showed lymphoblasts, and the cause of his hypertension was determined to be renal infiltration of leukemia cells due to B‐cell acute lymphoblastic leukemia.
Transvenous left bundle branch pacing during cardiac surgery: A case report
Authors: Wang Ning , Li Yan , Cheng Guanliang , Chen Xuezhi 
Published: November 2023

Key Clinical MessageLeft bundle branch pacing (LBBP) was a promising physiological pacing method, which could prevent or treat heart failure. We reported a young woman with severe valvular disease and heart failure receiving LBBP under direct vision and without x‐ray assistance during cardiac surgery. To the best of our knowledge, this was the first case report of this type of pace maker implantation.
A simple method for culturing Acanthamoeba from soft contact lens at a clinical laboratory of a hospital: Case report of Acanthamoeba keratitis
Authors: Matsuo Toshihiko , Nose Motoko 
Published: November 2023

Key Clinical MessageA simple culturing method for Acanthamoeba available at a clinical laboratory is a key for making timely diagnosis and starting treatment with topical 0.02% chlorhexidine gluconate eye drops, together with 0.1% miconazole or fluconazole eye drops.AbstractA 19‐year‐old woman with pain and injection in the right eye showed spotty corneal infiltration and radiating linear opacity. Suspicious of Acanthamoeba keratitis, corneal scraping, and the soft contact lens were sent to in‐house clinical laboratory to culture successfully Acanthamoeba on Sabouraud dextrose agar plate painted with heat‐treated dead bacilli.
Chairside posterior cantilevered fixed partial denture: Case report
Authors: Dupagne Lucien , Fouquet Vincent , Attal Jean‐Pierre 
Published: November 2023

Key Clinical MessageThe cantilevered fixed partial denture (CFPD) is gaining recognition as a sound method of replacing missing teeth in the posterior sector. The purpose of this case report is to demonstrate that this type of restoration can be performed in a single appointment. A 39‐year‐old patient presented herself to the dental department; she showed agenesis of the two first maxillary premolars with a totally closed mesio‐distal gap and a recent loss of the 2 s maxillary premolars. This case report concerns the replacement of the upper left second premolar. The patient was treated with a mesial CFPD resting on an “onlay‐like” retainer on the first molar and replacing the missing premolar with a cantilevered pontic. The dimensions of the connection's cross‐section were maximized as much as possible (>20 mm2). The restoration was designed and produced using chairside CAD‐CAM from a milled‐reinforced glass–ceramic block (Emax CAD, Ivoclar Vivadent). The aesthetic and functional integration of the prosthesis was successful. The patient was examined at 11 months for a follow‐up. At this early stage, satisfactory dental hygiene was observed, associated with a smooth prosthetic fit, no periodontal inflammation, normal probing, and no abnormal dental mobility.
Clival ectopic pituitary prolactinoma was successfully managed by transsphenoidal surgery: A rare case report
Authors: Mansour Marah , Khozamah Zeinah , Naksho Abdulmonem , Zayat Roaa , Al Sabbagh Aliaa , Deeb Ahmad 
Published: November 2023

Key Clinical MessageEctopic pituitary adenoma is a rare neoplasm located in the clivus and could mimic other clival tumors. Diagnosis and treatment could be challenging. It should be considered in the differential diagnosis of clival tumors.AbstractEctopic pituitary adenomas (EPAs) are isolated adenomas that can be located in variable locations outside the sella turcica and have a normal‐appearing pituitary gland. These tumors are rare and are thought to often arise from embryological remnants along the route of Rathke's pouch migration. EPAs are associated with a wide range of clinical manifestations depending on hormonal activity and involvement of adjacent structures, which can represent a challenge in making the diagnosis and deciding on the most appropriate management. In this case study, we report a 47‐year‐old male who presented with visual disturbances, a headache, and generalized weakness. Magnetic resonance imaging showed a 2 cm mass located in the clivus invading the sphenoid sinus with an intact pituitary gland. The patient underwent endoscopic transsphenoidal surgery to eradicate the mass while maintaining the integrity of the pituitary gland, which was successful and uneventful. Pathological studies were consistent with prolactinoma, with no cytological malignant features. Post‐surgery, symptoms notably improved, and serum prolactin levels significantly dropped, The patient's condition was satisfactory on follow‐up with no long‐term complications reported. This paper contributes to the existing literature by sharing the clinical management of a challenging and uncommon case.
Insight into the Stereoselective Synthesis of (1S)‐Nor(pseudo)ephedrine Analogues by a Two‐Steps Biocatalytic Process
Authors: Fracchiolla Noemi , Patti Stefania , Sangalli Fabio , Monti Daniela , Presini Francesco , Giovannini Pier Paolo , Parmeggiani Fabio , Brenna Elisabetta , Tessaro Davide , Ferrandi Erica Elisa 
Published: November 2023

AbstractNor(pseudo)ephedrines (N(P)Es), vicinal amino alcohols possessing sympathomimetic biological activity, constitute valuable intermediates and chiral building blocks for the organic synthesis of several active pharmaceutical ingredients (APIs). Due to the presence of two chiral centers, their conventional chemical asymmetric syntheses often involve long, multi‐step procedures, frequently with the aid of expensive and harmful metal catalysts, making it challenging to achieve high yields and optical purities overall. A two‐steps biocatalytic synthetic sequence for the preparation of (1S)‐N(P)E analogues was therefore designed and carried out, consisting of a benzoin‐type condensation catalysed by the (S)‐selective acetoin:dichlorophenolindophenol oxidoreductase (Ao:DCPIP OR) and a transamination mediated by either an (S)‐ or (R)‐selective amine transaminase (ATA). A multistep chemical synthesis of racemic N(P)Es was also optimised in order to obtain reference material for evaluating the performance of the biocatalysed reactions. The novel bi‐enzymatic synthesis provided the desired products with acceptable yields and good diastereo‐ and enantiomeric excesses, thereby paving the way for greener production of these important building blocks.
Assessing Electrocatalyst‐Ionomer Interactions: HOR/HER Activity of Pt/C Catalyst Layers incorporating Poly(imidazolium)s
Authors: Fraser Kate , Dosaev Kirill , Savinova Elena , Holdcroft Steven , Asset Tristan 
Published: November 2023

AbstractIn this work, a specifically designed C2‐protected poly(imidazolium) with a limited number of freely rotating phenyl groups was synthesized and studied as a binder for a commercial Pt/C electrocatalyst. The ionomer‐electrocatalyst interactions were extensively investigated in terms of kinetic and limiting current for the hydrogen oxidation reaction (HOR) and hydrogen evolution reaction (HER). A non‐monotonic evolution of the electrochemically active surface area (ECSA) was observed with the increase of the ionomer‐to‐carbon ratio. The addition of ionomer to the catalyst layer leads to an increase in stability and activity of the electrocatalyst during HOR, while substantially increasing the ionomer content leads to only a marginal decrease in ECSA. Potential phenyl adsorption and cation‐hydroxide ion‐water interactions which impart deleterious impact on electrochemical activity are minimized owing to the sterically encumbered design of the polyimidazolium which (i) limits direct molecular interaction of the imidazolium cationic ring with Pt and (ii) encumbers phenyl and imidazolium ring rotation to hinder parallel aromatic ring adsorption onto the electrocatalyst surface, hence mitigating strong adsorption/blocking interactions.
Affect and financial satisfaction: The mediating role of financial self‐efficacy
Authors: Olajide Olamide , Asebedo Sarah , Little Todd 
Published: November 2023

AbstractUsing the 2008, 2012, and 2016 waves of the Health and Retirement Study (HRS), this study employs Structural Equation Modeling (SEM) to investigate if financial self‐efficacy mediates the relationship between affective states (e.g., state‐like emotions) and financial satisfaction and if this differs for retirees and non‐retirees. The results show that retirees' negative affective state (negative affect) in wave 1 (2008) is related inversely to their financial self‐efficacy in wave 2 (2012), and financial self‐efficacy is related positively to financial satisfaction in wave 3 (2016). The results show that negative affect is associated with lower financial satisfaction through financial self‐efficacy as a mediating characteristic for retirees. However, for non‐retirees, no statistically significant mediation relationship is found. Findings from this study contribute to the gap in understanding the lingering effects of negative affect on financial behavior and financial satisfaction levels of older adults. This study provides insights into how financial planning practitioners can help clients navigate affective states and financial self‐efficacy as they work together to reach their financial goals.
Electron‐Triggered Imine Coupling: Synthesis and Characterization of Three Redox States (0,–1,–2) of a Ni(N2S2) Complex
Authors: Mangin Loïc P. , Albkuri Yahya M. , Ovens Jeffrey S. , Al Shehimy Shaymaa , Khrouz Lhoussain , Steinmann Stephan , Bucher Christophe , Baker R. Tom 
Published: November 2023

AbstractMetal imine‐thiolate complexes, M(NS)2 are known to undergo imine C−C bond formation to give M(N2S2) complexes (M=Co, Ni) containing a redox‐active ligand. Although these transfor‐mations are not typically quantitative, we demonstrate here that the one‐electron reduction of a related Ni bis(imine‐thiolate) complex affords the corresponding paramagnetic [Ni(N2S2)]‐ anion (2⋅−) exclusively; subsequent oxidation with [Cp2Fe]BF4 then affords a high yield of neutral 2 (Cp=η5‐cyclopentadienyl). Moreover, electrochemical studies indicate that a second one‐electron reduction affords the diamagnetic dianion. Both anionic products were isolated and characterized by SC‐XRD and their electronic structures were investigated by UV‐vis spectro‐electrochemistry, EPR and NMR spectroscopy, and DFT studies. These studies show that reduction proceeds primarily on the ligand, with (N2S2)4− containing both thiolate and ring‐delocalized anions.
Stabilization of sp‐Hybridized Nitrogen Cation by Lewis Acid‐Base Complex Formation with Intramolecular Iodine
Authors: Fujino Tomohiro , Hyodo Tadashi , Otani Yuko , Yamaguchi Kentaro , Ohwada Tomohiko 
Published: November 2023

AbstractHere we show that the sp‐hybridized nitrogen cation is strongly stabilized by a peri‐iodine substituent in the tetralone system. The cation is captured by anionic species such as CF3CO2−, affording hypervalent iodine(III) compounds with a short nitrogen‐iodine (N−I) bond, in which the cation serves as a Lewis acid. Notably, the O−I bond of the O‐trifluoroacetate or O‐acetate is intrinsically weaker than the N−I bond due to its more ionic character and is further weakened by protonation in trifluoroacetic acid. As a result, the oxygen ligand can dissociate in the presence of a Brønsted acid, affording a I+ cation intermediate that retains the N−I bond. We isolated the cation as the tetrafluoroborate, and characterized it experimentally by 1H NMR spectroscopy and X‐ray structure analysis, and theoretically by means of DFT calculation. The results suggest that the N−I bonded cation is intrinsically stable, and is weakly coordinated with water and the BF4 counter anion or trifluoroacetate anion. This cation can be employed as a reagent for α‐oxidation of ketones.
Stepwise Functionalization of a Pillar[5]arene‐Containing [2]Rotaxane with Pentafluorophenyl Ester Stoppers
Authors: Becharguia Nihed , Wasielewski Emeric , Abidi Rym , Nierengarten Iwona , Nierengarten Jean‐François 
Published: November 2023

AbstractDetailed investigations into the stepwise bis‐functionalization of a pillar[5]arene‐containing rotaxane building block have been carried out. Upon a first stopper exchange, the pillar[5]arene moiety of the mono‐acylated product is preferentially located close to its reactive pentafluorophenyl ester stopper, thus limiting the accessibility to the reactive carbonyl group by the nucleophilic reagents. Selective mono‐functionalization is thus very efficient. Introduction of a second stopper is then possible to generate dissymmetrical rotaxanes with different amide stoppers. Moreover, when dethreading is possible upon the second acylation, the pillar[5]arene plays the role of a protecting group allowing the synthesis of dissymmetrical axles that are particularly difficult to prepare under statistical conditions. Finally, detailed conformation analysis of the rotaxanes revealed that the position of the pillar[5]arene moiety on its axle subunit is mainly governed by polar interactions in nonpolar organic solvents, whereas solvophobic effects play a major role in polar solvents.
In‐situ temperature‐depth profile evaluation of South African unmineable coal seams to determine CO2 sequestration potential
Authors: Premlall Kasturie , Kipyegon Lawrence 
Published: November 2023

AbstractThis study aimed to investigate the sorption behaviour of South African coal seams with relation to the effect of temperature during CO2 sequestration. The excess adsorption isotherms of CO2 adsorption were undertaken using a high‐pressure volumetric system for four coals of different coal rank (denoted by Somkele [SK], anthracite KZN [AN], Tshikondeni [TD], and Syferfontein [SF]). The volumetric pressure step method was conducted at increments of system temperature of 35, 45, 55, and 65°C for pure CO2 adsorption at incremental pressures up to 93 bar. The results showed that high temperatures have a very significant negative effect on the amount of CO2 adsorbed on the coal samples. The high‐rank coal samples (SK and AN) demonstrated elevated CO2 adsorption capacity across all tested temperatures due to their high vitrinite content. The medium‐rank coals (TD and SF) exhibited comparatively lower CO2 adsorption capacity, attributed to the presence of adsorption hindrances such as higher ash content and volatile and mineral matter. The isosteric heat of adsorption revealed an increasing trend with coverage for all coal samples, with higher rank coals displaying greater slopes. The determined range of the isosteric heat of adsorption, spanning from 10 to 59 kJ/mol, indicated that the adsorption process is primarily of a physisorption nature. Three theoretical models (Langmuir, Freundlich, and Temkin) were evaluated and fitted to the sorption experimental data. The Temkin model exhibited superior fitting compared to the Langmuir and Freundlich isotherms. The Temkin isotherm parameters suggest that the adsorption of CO2 onto coal is a physisorption process.
Research on Electromagnetic Wave Absorption Based on Electrospinning Technology†
Authors: Li Baoding , Qiao Jing , Liu Yue , Tian Haoyuan , Liu Wei , Wu Qilei , Wang Zhou , Liu Jiurong , Zeng Zhihui 
Published: November 2023

Comprehensive SummaryAt present, in order to overcome electromagnetic interference and prevent electromagnetic harm, the research of new and efficient electromagnetic wave absorbing materials has become the research focus in the field of materials science. The one‐dimensional structure can promote the impedance matching and attenuation characteristics of the absorbing materials. Electrospinning, as an effective method to prepare nanofibers with high length‐diameter ratio, has been widely concerned because it is suitable for structural design of various materials. In this paper, the research progress and absorption properties of nano‐fiber materials prepared by electrospinning combined with different processes are introduced.
Synthesis, Structure and Chemical Bonding of Polyantimony Clusters Containing Coinage Metals [M2Sb14]4– (M = Cu, Ag)
Authors: Chen Wei‐Xing , Xu Yu‐He , Wang Cui‐Cui , Qiao Lei , Guo Zi‐Yan , Tian Wen‐Juan , Sun Zhong‐Ming 
Published: November 2023

Comprehensive SummaryBinary polyantimony clusters, namely [Cu2Sb14]4– and [Ag2Sb14]4–, containing coinage metals, were successfully synthesized and characterized, in which two homoatomic Sb73– subunits are bridged by two coinage metals in η4:η1 and η1:η1 coordination modes, respectively. In [Cu2Sb14]4–, two bridging Cu ions and two Sb atoms form a planar rhombic unit, which was revealed to have antiaromatic properties by theoretical calculations. Further electron structure and bonding analysis confirmed the presence of delocalized bonds in the rhombic unit and the metallophilic interaction between two formal M+ ions.
UNC‐82/NUAK kinase is required by myosin A, but not myosin B, to assemble and function in the thick filament arms of C. elegans striated muscle
Authors: Schiller NaTasha R. , Almuhanna Sarah A. , Hoppe Pamela E. 
Published: November 2023

AbstractThe mechanisms that ensure proper assembly, activity, and turnover of myosin II filaments are fundamental to a diverse range of cellular processes. In Caenorhabditis elegans striated muscle, thick filaments contain two myosins that are functionally distinct and spatially segregated. Using transgenic double mutants, we demonstrate that the ability of increased myosin A expression to restore muscle structure and movement in myosin B mutants requires UNC‐82/NUAK kinase activity. Myosin B function appears unaffected in the kinase‐impaired unc‐82(e1220) mutant: the recessive antimorphic effects on early assembly of paramyosin and myosin A in this mutant are counteracted by increased myosin B expression and exacerbated by loss of myosin B. Using chimeric myosins and motility assays, we mapped the region of myosin A that requires UNC‐82 activity to a 531‐amino‐acid region of the coiled‐coil rod. This region includes the 264‐amino‐acid Region 1, which is sufficient in chimeric myosins to rescue the essential filament‐initiation function of myosin A, as well as two sites that interact with myosin head domains in the Interacting Heads Motif. A specific physical interaction between myosin A and UNC‐82::GFP is supported by GFP labeling of ectopic myosin A filaments but not thin filaments. We hypothesize that UNC‐82 regulates assembly competence of myosin A during parallel assembly in the filament arms.