bluuebunny/crossref_metadata_2025_split huggingface dataset:
Importancia de las imágenes en la lectura
Authors: Enríquez Pantoja María Viviana 
Published: November 2023

La importancia de la lectura a través de las imágenes, también conocida como la comunicación ícono – verbal, permite realizar representaciones y expresar lo que se siente, piensa y desea para así transformar el contexto social y cultural de manera signicativa. Por consiguiente, interactuar por medio de esta no solo es trasmitir lo que quiere enunciar, sino concebir en el lector expectativas e inquietudes que conlleven a una respuesta adecuada después de haber entendido el mensaje; igualmente, la lectura de imágenes se establece como una estrategia importante porque genera desarrollo de producción textual agradable, entretenida, creativa y estimuladora del imaginario.
La validez de lo sencillo
Authors: Gómez Martínez Héctor Arturo 
Published: November 2023

Asombra la crónica del celador, que dichoso por haber aprendido a leer a sus más de cuarenta años, anhela la solidaridad o el dinero para adquirir el libro de sus sueños, que ahora puede leer pero no adquirir por falta de recursos, en irónico contraste con la época en la que el más simple folleto le signicaba todo un jeroglífico, porque sus nulos conocimientos lo empujaban al más angustioso oscurantismo.
Notas sobre el impacto de las nuevas tecnologías en los menores
Authors: Muñoz Criollo Ivan Alexander , Morán Cepeda Ingridh Lucía 
Published: November 2023

Las nuevas tecnologías se han convertido en herramientas casi indispensables en la sociedad actual. Muchos padres consideran un deber familiarizar al niño con estas –incluso permitirle divertirse con ellas por miedo a un rezago en las habilidades informáticas que le ocasione desventajas en su futura vida laboral. Estas herramientas, sin embargo, están lejos de ser neutrales, cambian hábitos saludables e impactan negativamente el desarrollo del niño. De la mano del trabajo del neurocientífco Manfred Spitzer se presenta por que son consideradas perjudiciales para el cerebro de los niños, así como las posibles secuelas de su uso.
Tiempo para preguntar
Authors: Acosta Díaz Emilio , Rojas Vergara Emma Del Pilar 
Published: November 2023

Hay tiempos para toda acción humana, este tiene la característica de ser una oportunidad elocuente para preguntarse, hacer un alto en la jornada y dejar que el espíritu nuevo de preguntas inunde la conciencia del ser y le permita recorrer caminos inesperados, dejando que el espíritu heterodoxo de la humanidad se recree en la inacabable búsqueda de respuestas. El escrito pretende detenerse en los estados apremiantes, el asombro, la dureza con la que es tocada la realidad humana de forma inesperada y la posibilidad de regocijarse en la sensatez animada por el espíritu.
Práctica pedagógica desde entornos virtuales en tiempos de pandemia
Authors: Ibarra Romo Dayra , Oliva Ramos Gerardo Andrés 
Published: November 2023

Conforme a la realidad que se ha vivido a partir de la emergencia de salud pública a nivel mundial a causa de la COVID-19, dentro del contexto educativo se han cambiado en un gran porcentaje los procesos de enseñanza aprendizaje, lo que ha permitido que los diferentes actores como estudiantes, docentes, padres de familia y directivos hayan implementado nuevas formas de pensamiento y desarrollo para la construcción del conocimiento en un contexto totalmente diferente al de la escuela; gracias a ello han surgido nuevas estrategias pedagógicas desarrolladas desde la virtualidad.
A propósito de estos tiempos de pandemia, el Ministerio de Educación Nacional de Colombia generó una serie de encuentros virtuales denominada Charlas con maestros, cuyo desarrollo se ha llevado a cabo en 2020, en este artículo se destacan algunos de sus aportes.
Los Derechos Básicos de Aprendizaje (DBA), como declaraciones para establecer los procesos de aprendizaje
Authors: Portilla Benavides Milton Mauricio 
Published: November 2023

Los Derechos Básicos de Aprendizaje (DBA), son los aportes más recientes desde el Ministerio de Educación Nacional hacia la apuesta por la calidad y la excelencia educativa, estos como ruta de trabajo en las aulas orientan el quehacer docente, facilitan la práctica pedagógica, favorecen el desarrollo de competencias básicas y hacen más comprensible la implementación de los Estándares Básicos de Competencias; de ahí que la apuesta desde los entornos escolares, sea su adecuación a los Proyectos Educativos Institucionales, planes de área y de aula que en conjunto deben garantizar la equidad y la disminución de brechas sociales en educación.
Las mujeres negras e indígenas por sus derechos
Authors: Zuleta Medina Alejandra 
Published: November 2023

El presente se categoriza como artículo de reflexión y análisis de contenido documental. Surge a raíz de la necesidad de indagar ¿cómo se han presentado los movimientos de mujeres negras e indígenas por la igualdad? En aras de responder a esta inquietud se ha realizado una breve revisión documental, a nivel nacional e internacional, con el fin de elaborar una reconstrucción sociohistórica del tema.
El artículo se divide en dos grandes partes, cada una de ellas tratando de brindar una aproximación a la situación de las mujeres negras y las mujeres indígenas. Finalmente, se concluye que pese al reconocimiento a estos movimientos aún se evidencian serias dificultades asociadas al racismo y a la discriminación contra las mujeres.
Cost-effectiveness analysis of encorafenib and binimetinib combination as first-line treatment for metastatic or unresectable <i>BRAF</i> V600-mutated metastatic melanoma in Russia
Authors: Avxentyev N. A. , Makarova Yu. V. 
Published: November 2023

Objective: to perform a cost-effectiveness analysis of using encorafenib and binimetinib combination in the first-line therapy for metastatic or unresectable BRAF V600-mutated melanoma in the Russian Federation. Material and methods. The comparators included “dabrafenib + trametinib” combination and vemurafenib monotherapy, which are listed in the Russian clinical guidelines and the Vital and Essential Drugs List. Since “encorafenib and binimetinib” combination demonstrated superior overall response rate compared to “dabrafenib + trametinib” and vemurafenib monotherapy, the method of cost-effectiveness analysis was used. We developed a disease progression model based on data from the COLUMBUS randomized control trial and published network meta-analysis. The model was used to calculate the direct medical costs associated with the considered alternatives over a 3-year modeling horizon. We compared the incremental cost-effectiveness ratio for “encorafenib + binimetinib” vs. “dabrafenib + trametinib” to the same ratio calculated for “dabrafenib + trametinib” vs. vemurafenib monotherapy.Results. Mean costs of using “encorafenib + binimetinib” combination over a 3-year period, considering the discontinuation of treatment as the disease progresses, was 6,547,693.07 rubles. Meanwhile, it was 5,962,742.52 rubles for “dabrafenib + trametinib” and 2,581,781.45 rubles for vemurafenib monotherapy. The incremental cost-effectiveness ratio of “encorafenib + binimetinib” vs. “dabrafenib + trametinib” was 3,846,818.71 rubles per 1 patient with a response to therapy. This was 85.14% lower than the same ratio estimated for “dabrafenib + trametinib” vs. vemurafenib monotherapy (25,890,022.64 rubles per 1 patient with a response to therapy).Conclusion. The “encorafenib + binimetinib” combination is a cost-effective treatment method for patients with unresectable or metastatic BRAF V600-mutated melanoma in the Russian Federation.
An open-label, controlled trial of the clinical effects of Laennec® in patients with nonalcoholic steatohepatitis or cirrhosis
Authors: Imawari M. , Nagase M. , Torshin I. Yu. , Gromova O. A. 
Published: November 2023

Objective: to evaluate the efficacy and safety of human placenta hydrolysate (HPH) Laennec® in the treatment of nonalcoholic fatty liver disease (NAFLD) in a clinical trial.Material and methods. The study involved hospitalized NAFLD patients (with non-alcoholic steatohepatitis, cirrhosis) (n=34, mean age 53±14 years). In the therapy group (n=17), patients received Laennec® HPH (4 ml intravenous drip infusion in a solution of 5% glucose 5 times a week for 2 weeks). In the control group (n=17), patients hospitalized in other departments of the clinic did not receive any therapy for NAFLD. The effectiveness of therapy was assessed after 2 and 3 weeks by subjective NAFLD symptoms (fatigue, anorexia, bloating, constipation, nausea, and pain in hypochondrium) and biochemical indicators of liver function: levels of blood serum aspartate aminotrans-ferase (AST), alanine notransferase (ALT), gamma-glutamyltransferase (GGT).Results. At the start of the study, there were no significant differences between the groups in the values of the studied indicators of liver function: blood levels of AST, ALT, GGT, etc. By the end of Week 1, a significant decrease in AST levels was registered in the group receiving Laennec® (–35 U/l; control: –8 U/l; p<0.001), ALT (–45 U/l; control: –10 U/l; p<0.001), and GGT (–23 U/l; control: –8 U/l; p=0.084; trend). At the end of the study (Week 3), the decrease in AST, ALT and GGT levels towards the normal range was even more pronounced for all three biomarkers: AST (–62 U/l; control: –23 U/l; p<0.001), ALT (–78 U/l; control: –20 U/l; p<0.001), GGT (–40 U/l; control: –15 U/l; p=0.005). Subjective NAFLD symptoms significantly improved after 3 weeks. No adverse effects were identified with the use of HPH. Conclusion. Laennec® is an effective and safe treatment for NAFLD.
Efficacy of alectinib in comparison with lorlatinib in patients with ALK-positive non-small cell lung cancer: pharmacoeconomic study
Authors: Kolbin A. S. , Gomon Yu. M. , Proskurin M. A. , Balykina Yu. E. 
Published: November 2023

Objective: to evaluate the clinical and economic effectiveness of alectinib in comparison with lorlatinib in adult patients with advanced anaplastic lymphoma kinase (ALK) positive non-small cell lung cancer (NSCLC).Materials and methods. The calculations included the direct costs of the healthcare system: the costs of drug therapy, detecting and relieving adverse events, palliative care. A Markov model consisting of three patient states (“alive without progression”, “alive with progression”, “death”) was constructed, the probabilities of which were obtained from previously conducted clinical studies. Due to the equivalence of strategies regarding overall and non-progressive survival, the cost minimization analysis was applied.Results. The total costs per 1 patient when using lorlatinib were 40.63% higher than for alectinib (12,551,770 and 7,451,522 rubles, respectively). At the same time, the difference was mainly determined by different costs of targeted therapy: in the alectinib group, the cost of drug therapy per 1 patient amounted to 6,646,247 rubles, in lorlatinib group – to 11,922,814 rubles (44% higher).Conclusion. The use of alectinib in the treatment of patients with ALK-positive NSCLC is justified not only from clinical, but also from an economic point of view.
Costeo empaques de panela, planta de café Majavita.
Authors: Sastre Martínez Dara Daniela , Benítez Heredia Oscar Eduardo , Muñoz Torres Josef Grimaldi , Gualdrón López Alfonso Enrique 
Published: November 2023

En la Hacienda Majavita de la Universidad Libre Seccional Socorro funciona la Planta de Café́ Majavita, la cual tiene como actividad principal la producción y procesamiento de café́. Sin embargo, en esta se desarrollan otras actividades como lo son el empaque de panela en sobres, los cuales se distribuyen en las sedes de la Seccional Socorro como endulzantes.
El objetivo de esta investigación es determinar los costos de producción que conllevan la producción de empaques de panela a través de la aplicación de un sistema de costeo. En este caso se aplicaron dos costeos: variable y total.
Theruptor novo: wound dressing for diabetic foot ulcer
Authors: Pavan B. 
Published: November 2023

One of the main risk factor affecting the normal wound healing process of is diabetes. India being the capital for diabetes, has a prevalence of 9.6% with 74 million patients living with diabetes and is expected to be 124 million by 2045. The most dreadful complication of diabetes mellitus is the diabetic foot ulcer. Foot ulcer and amputation are among the leading reasons for high morbidity, healthcare costs and mortality in diabetes patients. Numerous things must come together for a chronic wound to heal, and one crucial component of care is the use of wound dressings and these should create an ideal environment for healing while safeguarding the site from infection and additional damage. A diabetic patient presented with a non-healing diabetic foot ulcer (10.83 cm2) with severe loss of protective sensation, exposed excised fourth and fifth metatarsals and he was treated and followed up with regular normal saline washes and Theruptor Novo dressings. The wound started to show signs of healing and within 7 weeks, the wound healed with complete epithelization. Theruptor Novo dressing was helpful in terms of good granulation tissue growth and epithe­lialization over time with good exudate management. Theruptor Novo, a non-adherent dressing with unique antimicrobial action cab be useful in managing diabetic foot ulcers.
Theruptor Novo dressing for an infected diabetic foot ulcer: a case study
Authors: Pavan B. 
Published: November 2023

In diabetes mellitus (DM) patients with peripheral neuropathy, the diabetic foot infection (DFI) often begins with a small wound that patients may not easily detect and then progresses to a more complex wound. Diabetic foot ulcer (DFU) is estimated to occur in approximately in 25% of individuals with diabetes in India. The bacterial infection is one of the important cause for the chronicity of DFU and are accountable for the high medical costs as well as affecting patients’ quality of life significantly. Preventing DFU secondary infections is an important function of wound dressing. There are many wound dressings available for DFU, and choosing the right dressing is one of the important parameter in the management and ultimately preventing the limb amputation. In this case, the patient presented with non-healing infected DFU and we used Theruptor Novo dressings for the wound management. The Theruptor Novo dressing was efficient in exudate management and preventing secondary infection which helped in accelerated DFU healing.
Volumetric analysis of pharyngeal airway dimensions and hyoid bone position following orthognathic surgery in skeletal class III patients: a cross sectional cephalometric study
Authors: Thapa Amrit , Roy I. D. , Jayan B. , Ray Saugat , Kumar Andrews Navin , Antil Amit 
Published: November 2023

Background: Objective of the study was to determine linear and volumetric changes in pharyngeal airway dimensions in class III patients treated by different modalities of orthognathic surgery and to compare the results of different orthognathic surgical modalities, and determine the change at the position of the hyoid bone.
Methods: Pre and post-treatment lateral cephalogram of 53 class III adult patients who were treated by different modalities of orthognathic surgery studied to assess the changes in pharyngeal airway dimensions and hyoid bone position after orthognathic surgery. 28 patients were treated with mandibular set back, and 25 patients were treated with Bijaw surgery. Lateral cephalogram records were taken before treatment (T1), after surgery (T2), the end of the fixed treatment (T3) and 1 year after debonding (T4).
Results: Interception of both surgical modalities has significant impact on various skeletal and pharyngeal parameters i.e., BMeH (0.00), PNS (0.009), MPS (0.13), GOP (0.001), IPS (0.007), SAS (0.006), and MAS (0.00). OJ (overjet) and OB (overbite) was significant especially after time interval of one year. In Bijaw groups, PPST4 parameter was significantly increased (0.0000), SPST4 (0.000), GOP (0.000), EPS (0.000) and IPS parameter was significantly decreased (0.045). Significant difference was observed in T4 time interval in superior pharyngeal airway space, posterior airway space and middle airway space with (p<0.05).
Conclusions: Pharyngeal airway is significantly altered following orthognathic surgery in class III patients and it depends on the type of surgical modality employed were Bijaw surgery has significant impact on oropharyngeal and hypopharyngeal airway space.
The potential of e-books to improve college students’ self-directed learning in biology
Authors: Rahmi Fitri Olvia , Suryawati Evi , Mahadi Imam 
Published: November 2023

Independence in learning is very necessary for the application of online learning. Students as learners must have Self Directed Learning. This study aims to develop independent learning resources to facilitate student learning independence. Development research using the ADDIE model is carried out until the development stage. Needs analysis is conducted on 49 Biology Education Students with data collection instruments using the SDL test consisting of 5 question indicators: 1) Identifying learning needs; 2) Set up study routines and discover concept mappings; 3) Using concept/outline mapping as a useful understanding various information; 4) Self-assessment, honing potential; 5) Can explore self-ability. The test results show that in indicator 1 there are 9 students (18.37%) and indicator 5 as many as 11 students (22.45%) who have SDL abilities. The results of the needs analysis become the basis for the development of interactive electronic books through features such as material summaries, images, animations, videos, references (links and barcodes), interactive exercises, keywords, interest facts, practice questions, formative tests, and reflections. It is hoped that this interactive e-book can increase the independence of undergraduate and PPG students in studying biotechnology material as a source of independent learning.Abstrak Kemandirian belajar sangat diperlukan dalam penerapan pembelajaran daring. Mahasiswa sebagai pembelajar harus memiliki kemandirian belajar (Self Directed Learning/SDL). Penelitian ini bertujuan untuk mengembangkan sumber belajar mandiri untuk memfasilitasi kemandirian belajar mahasiswa. Penelitian pengembangan menggunakan model ADDIE penelitian ini dilakukan sampai tahap development. Analisis kebutuhan, dilakukan pada 49 orang Mahasiswa Pendidikan Biologi dengan instrumen pengumpulan data menggunakan tes SDL terdiri dari 5 indikator pertanyaan: 1) Mengidentifikasi kebutuhan belajar; 2) Mengatur rutinitas belajar dan menemukan pemetaan konsep; 3) Menggunakan pemetaan konsep/garis besar sebagai metode yang berguna untuk memahami berbagai informasi; 4) Menilai sendiri, merefleksikan dan mengasah potensi; 5) Bisa mengeksplor kemampuan diri. Hasil tes menunjukkan pada indikator 1 sebanyak 9 orang (18,37%) dan 5 sebanyak 11 orang (22,45%) yang memiliki kemampuan SDL. Hasil analisis kebutuhan menjadi dasar untuk pengembangan buku elektronik interaktif melalui fitur-fitur barupa ringkasan materi, gambar, animasi, video, referensi (link dan barcode), latihan interaktif, key word, interesring fact, latihan soal, tes formatif dan refleksi. Diharapkan e-book interaktif ini dapat meningkatkan kemandirian mahasiswa S1 dan PPG dalam mempelajari materi bioteknologi sebagai sumber belajar mandiri.
Effectiveness of popular scientific books on Fabaceae plant in KHDTK ULM to improve critical thinking skill
Authors: Khatimah Husnul , Arifin Yudi Firmanul , Putra Aminuddin Prahatama 
Published: November 2023

Local potential can be used as a learning resource to preserve community knowledge in using specific plants and instil a sense of love in students for the potential in their area. Learning resources like Popular Scientific Books (PSB) based on local potential can train students' critical thinking skills. The research aims to describe the effectiveness of the PSB Fabaceae ethnobotany in Forest Areas with Special Purposes (KHDTK) ULM training students' critical thinking skills. The research method uses the Educational Design Research (EDR) model through Tessmer's formative evaluation. The development stages include a small group of 5 students and a field test of 20 Biology Education undergraduate students who have passed the Ethnobotany course one year. Students' critical thinking skills are improved through working on practicum guides and evaluation questions, which contain aspects of critical thinking skills. The research results of students' critical thinking skills are in the medium category, with an average N-Gain of 0.5. Based on these results, it can be concluded that BIP effectively improves students' critical thinking skills. Students who have critical thinking skills are expected to be able to improve the quality of human resources, especially in the field of education.Abstrak Potensi lokal dapat dijadikan sumber belajar untuk melestarikan pengetahuan masyarakat dalam pemanfaatan tumbuhan tertentu dan menanamkan rasa cinta mahasiswa terhadap potensi di daerahnya sendiri. Sumber belajar berupa Buku Ilmiah Populer (BIP) berbasis potensi lokal dapat melatihkan keterampilan berpikir kritis mahasiswa. Tujuan penelitian untuk mendeskripsikan keefektifan BIP etnobotani Fabaceae di Kawasan Hutan dengan Tujuan Khusus (KHDTK) ULM dalam melatihkan keterampilan berpikir kritis mahasiswa. Metode penelitian menggunakan model Educational Desain Research (EDR) melalui evaluasi formatif Tessmer. Tahapan pengembangan meliputi kelompok kecil 5 mahasiswa dan uji lapangan 20 mahasiswa S1 Pendidikan Biologi yang telah lulus mata kuliah Etnobotani. Keterampilan berpikir kritis mahasiswa ditingkatkan melalui pengerjaan penuntun praktikum dan soal evaluasi yang memuat aspek keterampilan berpikir kritis. Hasil penelitian keterampilan berpikir kritis mahasiswa berkategori sedang dengan rata-rata N-Gain 0,5. Berdasarkan hasil tersebut dapat disimpulkan BIP efektif dalam meningkatkan keterampilan berpikir kritis mahasiswa. Mahasiswa yang memiliki keterampilan berpikir kritis diharapkan mampu untuk meningkatkan kualitas sumber daya manusia khususnya di bidang pendidikan.