bluuebunny/crossref_metadata_2025_split huggingface dataset:
Manganese‐Resorcin[4]Arene‐Based Metal‐Organic Framework: Syntheses, Structure and Lithium‐Ion Battery Application
Authors: Liu Jin‐Hua , Liu Dan , Yu Ming‐Yue , Liu Li , Wang Yan‐Qing , Huo Yan‐Fang , Sun Shi‐Qi , Hao Sha‐Sha 
Published: February 2025

AbstractBy employing a dodecarboxylic acid substituted resorcin[4]arene ligand (L), a new metal‐organic framework (MOF), [Mn6(L)(H2O)14] ⋅ DMA ⋅ 5H2O (defined as Mn‐L) has been synthesized under solvothermal conditions. Mn‐L shows a 3D framework with abundant carboxyl groups, which result in the excellent electrochemical performance as anode materials in lithium ion batteries (LIBs). The activated Mn‐L maintains the specific capacities of 598 mAh/g at 200 mA/g after 150 runs and 420 mAh/g at 500 mA/g after 350 runs. The excellent rate capacity, cyclic stability enable Mn‐L to be prospective anode material for LIBs.
A case of multiple bone metastases during the course of non‐invasive bladder and prostate cancer
Authors: Matsubara Keisuke , Hayakawa Nozomi , Kubota Yohei , Ohike Nobuyuki , Sunakawa Yu , Koike Junki , Kikuchi Eiji 
Published: February 2025

IntroductionSecondary bladder tumor is rare. We report a case of a bladder tumor initially thought to be a recurrence of non‐muscle invasive bladder cancer that was ultimately identified as metastasis from gastric cancer treated 16 years prior.Case presentationA 75‐year‐old male with a history of gastric, prostate, and recurrent non‐muscle invasive bladder cancer was diagnosed to have multiple bone metastases. Open bone biopsy and cancer gene panel testing identified the primary origin of the metastases as gastric cancer. Retrospective evaluation revealed that what was initially suspected as recurrent bladder tumors were actually metastases from the gastric cancer.ConclusionIn cases of metastases with an unknown primary origin, detailed evaluation, including biopsy of the metastatic lesion and genomic testing, is recommended.
Low‐Energy Electron Beam Modification of Metallic Biomaterial Surfaces: Oxygen and Silicon‐Rich Amorphous Carbon as a Wear‐Resistant Coating
Authors: Kurtz Peter W. , Lee Hwaran , Mace Annsley , Goodwin Charley , Gilbert Jeremy 
Published: February 2025

ABSTRACTMetallic biomaterials, such as cobalt chrome molybdenum (CoCrMo), Ti‐6Al‐4V, and 316L stainless steel are commonly used in orthopedic implant devices. Damage modes such as corrosion and wear are associated with the use of these alloys. One solution to limit wear and corrosion damage is to apply a surface coating to the medical device. In this study, using the low‐energy electron beam (LEEB) of scanning electron microscopy (SEM), we induced a highly scratch‐resistant oxygen and silicon‐rich amorphous carbon film to grow on each of the above metallic biomaterials. LEEB interaction with adventitious surface carbon, silicone, and oxygen deposited on the above three alloys resulted in the layered‐deposition formation (LEEB‐LD) of a surface coating. Coating chemistry, morphology, and nano‐scratch wear properties on each of the three alloys were characterized using atomic force microscopy (AFM) scratch testing and SEM/Energy dispersive spectroscopy (EDS) analysis. We hypothesized that LEEB‐LD coatings could be deposited on these three metallic biomaterials with improved tribological properties than the underlying metal substrate. First, we generated coatings on all three biomaterials and documented the coating morphology (thickness and heterogeneity) and chemistry as a function of alloy, exposure time, and scan rate with coating thicknesses generated between 5 and 50 nm after 60 min of treatment, with each factor affecting the thickness. EDS maps showed high amounts of carbon, oxygen, and silicon in the modified surface which depended on the alloy (e.g., CoCrMo and SS had similar compositions while Ti had higher oxygen in the coatings). Coated and uncoated surfaces were then subjected to diamond scratch testing in an AFM at increasing force until the coating delaminated from the surface. Scratch‐depth versus load and nominal Hertzian stress were plotted for both the uncoated and coated surfaces. We found that scratch depths were 40%, 75%, and 38% smaller on CoCrMo, Ti, and SS coatings, respectively, at the peak contact stresses tested (⍺ < 0.05), indicating higher hardness and wear resistance for the coatings. These results support the hypothesis that controlled thickness LEEB‐LD oxygen and silicon‐rich amorphous carbon coatings can be systematically generated using low‐power electron beams and that these coatings have increased tribological (scratch‐resistance) properties compared to the substrate metal.
Myricetin Modulates Matrix Metalloproteinases Expression Induced by TEGDMA in Human Odontoblast–Like Cells
Authors: Baldión Paula Alejandra , Díaz Carlos Aldemar , Betancourt Diego Enrique 
Published: February 2025

ABSTRACTThe activity of matrix metalloproteinases (MMPs) plays a crucial role in the aging of the resin–dentin interface. The in situ action of MMP‐2 and MMP‐9 has been confirmed in the process of dentin‐collagen degradation. However, the involvement of dental pulp cells in MMP secretion as a response to oxidative stress induced by contact with resin monomers has not been fully elucidated. Myricetin (MYR), like proanthocyanidin (PAC), has antioxidant properties and may help prevent extracellular matrix degradation. The objective was to evaluate the effect of MYR on the MMP expression and activity in response to reactive oxygen species (ROS) increase induced by triethylene glycol dimethacrylate (TEGDMA) in human odontoblast–like cells (hOLCs). hOLCs differentiated from dental pulp mesenchymal stem cells were exposed to TEGDMA released from dentin blocks using a barrier model with transwell inserts for 18, 24, and 36 h. Intracellular oxidation was evaluated using the 2′,7′‐dichlorofluorescein probe. The effect of 600 μM MYR on the MMP‐2 and MMP‐9 expression was determined by reverse transcription‐quantitative polymerase chain reaction (RT‐qPCR). The extracellular MMP levels were quantified using enzyme‐linked immunosorbent assay, and their activation by means of a proteolytic fluorometric assay. The results were analyzed by one‐way analysis of variance and Tukey's post hoc test, p ≤ 0.05. TEGDMA exposure increased intracellular ROS and upregulated MMP‐2 and MMP‐9 mRNA in hOLCs (p < 0.001). The levels of MMPs increased significantly 24 h after TEGDMA exposure (p = 0.013). These secreted proteases exhibited high activation ability. MYR reduced ROS production and downregulated MMP expression and activity at both mRNA and protein levels, similar to the effect found for PAC, which was used as a control. A relationship was observed between MMP‐2 and MMP‐9 expression, secretion, and early activation with ROS increase due to TEGDMA exposure. MYR showed potential as a therapeutic strategy to control MMP expression and modulate redox imbalance, offering a protective effect on cellular response.
Recent Advances in Integrated Organ‐Chip Sensing Toward Robust and User‐Friendly Systems
Authors: Schellberg Bryan G. , Koppes Ryan A. , Koppes Abigail N. 
Published: February 2025

ABSTRACTOrgans‐on‐a‐chip (OOC) are an emergent technology that bridge the gap between current in vitro and in vivo models used to inform drug discovery and investigate disease pathophysiology. These systems offer improved bio‐relevance and controlled complexity through the integration of physical and/or chemical stimuli matched to physiologically relevant conditions. Although significant advancements have been made toward recreating organ‐specific physiology on chip, the methods available to study structure and function of the cell microenvironment are still limited. Established analysis approaches, including fluorescence microscopy, rely on laborious offline workflows that yield limited time‐point data. As the OOC field continues to evolve, there is a unique opportunity to engineer improved characterization methods into organ‐chip devices. This review provides an overview of current integrated sensing approaches that address current limitations and enable real‐time readout of relevant physiological parameters in OOC.
Investigating the Effect of Thickener Concentrations on the Corrosion Behavior of Pure Mg
Authors: Sahu Manas Ranjan , Yamamoto Akiko 
Published: February 2025

ABSTRACTMagnesium (Mg) and its alloys are promising biodegradable implant materials due to their biocompatibility and ease of corrosion in physiological environment. In the tissue, diffusion of ions and gas released by Mg corrosion reaction will be interfered by extracellular matrix and cells, which may retard the corrosion reaction. Therefore, in the present study, we developed the in vitro model tissue with different diffusion rates to understand the effect of diffusion on the Mg corrosion. A thickener called gellan gum was added to the cell culture medium at appropriate concentrations to simulate tissues with different diffusion rates. The immersion study up to 28 days and the electrochemical studies were performed to evaluate the Mg corrosion behavior. The pure Mg specimens without thickener showed the highest corrosion rate in both immersion and electrochemical tests. The highest amount of insoluble salt layer with the lowest Mg and highest O concentrations were deposited on the specimen surface without thickener. The microfocus X‐ray computed tomography (μCT) analysis confirmed these findings, showing the lowest remaining volume for specimens without thickener. There is an impediment of ion diffusion in the model tissue with increased thickener concentrations, thereby decreasing the corrosion rate. The corrosion rate for 0.2–0.3 wt. % thickener matched in the range of reported in vivo results. Hence, this model proves to be an effective tool for investigating biodegradation and understanding the mechanisms and controlling factors of this phenomenon.
Rapid Quantitative Assessment of Muscle Sodium Dynamics After Exercise Using 23Na‐MRI in Dysferlinopathy and Healthy Controls
Authors: Neal Mary A. , Bolano‐Diaz Carla F. , Richardson Mark , Michell‐Sodhi Jassi , Muni‐Lofra Robert , James Meredith K. , Hollingsworth Kieren G. , Hilsden Heather , Wilson Ian , Blamire Andrew M. , Straub Volker , Thelwall Peter E. , Diaz‐Manera Jordi 
Published: February 2025

ABSTRACTBackgroundDysferlin plays a key role in cell membrane repair; its absence or malfunction in patients with dysferlin‐deficient limb girdle muscular dystrophy leads to muscle fibre death. Muscle magnetic resonance (MR) imaging allows non‐invasive and repeatable measurements that can report on pathological changes observed in dysferlinopathy patients (DP). We aimed to demonstrate the feasibility of utilising volume‐localised 23Na spectroscopy as a novel approach to characterise muscle Na+ content and biexponential T2* at rest, and dynamically post‐exercise, in patients with dysferlinopathy and in matched healthy controls.MethodsAdult DP and age and sex matched healthy volunteers (HV) were recruited and scanned on a 3 T clinical MR scanner. Following baseline scans, participants performed physiotherapist‐guided isometric dorsiflexion contractions until tibialis anterior (TA) muscle exhaustion. Dynamic volume‐localised sodium‐23 (23Na)‐ and proton (1H)‐MR scans were acquired serially for 35 min post‐exercise. MR data were analysed to determine TA lipid content, change in TA sodium content, biexponential sodium T2* properties and TA water 1H T2.ResultsTen DP (mean age ± standard deviation [SD]: 38.0 ± 10.8 years; 80% female) and 10 HV (mean age ± SD: 38.9 ± 11.5 years) were scanned. Baseline muscle water 1H T2 and sodium concentration were significantly higher in DP compared to matched controls (1H T2 DP [SD] = 33.8 [2.7] ms, 1H T2 HV = 29.3 [1.1] ms, p < 0.001; [23Na]DP = 36.2 [11.4] mM, [23Na]HV = 19.6 [3.1] mM, p < 0.001). 1H T2 and sodium content in healthy controls showed significant post‐exercise elevation with a slower time‐to‐peak for sodium content compared to 1H T2. 1H T2 and sodium content change post‐exercise was highly variable in the DP group. Notably, 23Na dynamics in one DP with normal muscle fat fraction were similar to HV. Biexponential 23Na T2* was measured at baseline in HV (T2*slow = 13.4 [2.3] ms, T2*fast = 2.2 [1.3] ms), and DP (T2*slow = 14.0 [1.5] ms and T2*fast = 1.0 [0.5] m). Equivalent measurements post‐exercise revealed an increase in the fraction of the slow‐relaxing component in HV (p < 0.05), consistent with oedematous changes.ConclusionsAssessment of TA muscle fat fraction, 1H T2, sodium content and sodium T2* relaxation properties revealed differences at baseline and in post‐exercise dynamics between patients with dysferlinopathy and matched controls. Post‐exercise 23Na recovery dynamics followed a well‐defined time course in HV. Heterogeneous alterations in sodium content and MR relaxation properties in DP may reflect altered ion homeostasis associated with chronic muscle damage.
Trends in resource utilization for new‐onset psychosis hospitalizations at children's hospitals
Authors: Gupta Ankita , Hall Matt , Masserano Benjamin , Wilson Averi , Johnson Katherine , Chen Clifford , Challa Lasya , Katragadda Harita , Mittal Vineeta 
Published: February 2025

AbstractBackgroundChildren with new‐onset psychosis often require hospitalization for medical evaluation.ObjectivesThe goal of this study was to assess variations in the management of children with new‐onset psychosis and characterize trends in resource utilization.MethodsThe study included index hospitalizations for children ages 7–18 admitted to children's hospitals with a primary diagnosis of psychosis from 2011 to 2022 using the Pediatric Health Information System (PHIS) database. Children with a complex chronic condition were excluded. Resource utilization categories included medication, imaging, laboratory, and other clinical resources. Variability in resource utilization was assessed using covariance tests for random intercepts with generalized linear modes after adjusting for age, sex, payor, and severity. Trends in resource utilization were examined using generalized estimating equations adjusting for the same factors and accounting for hospital clustering.ResultsOur data set included 7126 new‐onset psychosis hospitalizations from 37 children's hospitals. Teenage males and non‐Hispanic Whites were most likely to be hospitalized. There was a significant variation in resource utilization across hospitals in all categories (p < .001). The most frequently utilized resources were antipsychotic medications (76%), serum chemistry (77%), toxicology labs (72%), and brain magnetic resonance imaging (22%). The most notable increases in utilization were in the performance of laboratory tests, brain imaging, anesthetic use, and intravenous immunoglobulin use.ConclusionStudy findings suggest that there has been a stable rate of hospitalization for children with new‐onset psychosis, yet a significant variation in the medical evaluation exists. Significant increases and variations in resource utilization across all categories suggest an emerging need for robust evidence and consensus‐based practice guidelines.
Carpal Kinematics in the Normal, Scapholunate Ligament Deficient, and Surgically Reconstructed Wrist
Authors: Zhang Xin , Tham Stephen K. , Crepaldi Bruno , Ek Eugene T. , McCombe David , Ackland David Charles 
Published: February 2025

ABSTRACTThe objective of this study was to evaluate scaphoid, lunate and capitate kinematics after disruption to the primary and secondary scapholunate ligamentous stabilizers, and to assess the effectiveness of scapholunate ligament reconstruction in restoring carpal kinematics post‐operatively. Seven upper extremities were harvested, and the scapholunate interosseous ligament (SLIL) was divided. Specimens were mounted onto a computer‐controlled dynamic wrist simulator, and simulations of flexion‐extension, radial‐ulnar deviation, and dart‐thrower's motion were undertaken by simulated force application to the wrist tendons. Three‐dimensional kinematics of the scaphoid, lunate and capitate were measured using bi‐plane X‐ray fluoroscopy in the native and ligament deficient state. The SLIL was then reconstructed by either dorsal transarticular loop tenodesis (DTLT), or by the three‐ligament tenodesis (3LT) technique, and re‐evaluated. SLIL deficiency resulted in significant differences in carpal kinematics compared to that in the healthy wrist across all wrist motions (p < 0.05). The DTLT procedure corrected increased scaphoid ulnar deviation and pronation in the SLIL deficient wrist, but did not significantly improve scaphoid flexion or volar translation of the scaphoid. The 3LT reconstructive technique restored scaphoid flexion and ulnar deviation but did not correct pronation, the increased lunate extension, nor the volar and ulnar translation observed in the ligament deficient wrist. Three‐dimensional scaphoid, lunate and capitate motion depends on SLIL integrity, with tears to this ligament resulting in pathological kinematics, which may be partially mitigated with DTLT and 3LT surgical reconstruction. These findings suggest that this surgical reconstruction of the SLIL may not mitigate long‐term degenerative joint conditions at the wrist.
Health and Ecological Risk From Potentially Toxic Elements in Soils and Extra Virgin Olive Oils From Valdichiana Senese, Tuscany (Italy)
Authors: Grattacaso Martina , Canali Giulia , Vannini Andrea , Protano Giuseppe , Nannoni Francesco , De Lucia Vivien , Lella Luigi Antonello Di , Biagiotti Stefano , Loppi Stefano 
Published: February 2025

ABSTRACTBackgroundExtra virgin olive oils (EVOOs) are widely consumed but rarely analysed for potentially toxic elements (PTEs), whose concentrations in EVOOs can be significantly influenced by contamination in olive grove soils. As food consumption is the main PTE accumulation pathway in humans, thorough investigation on EVOOs is necessary.AimThe concentrations of 12 PTEs were determined in olive grove soils and EVOOs from Valdichiana Senese (Southern Tuscany, Italy), with the aim of identifying any contamination by PTEs in olive grove soils and evaluating the associated ecological risk as well as of assessing the potential risk for human health related to PTE intake from EVOO consumption.MethodsThe soil and EVOO samples were collected from 18 farms, and the concentration of As, Cd, Co, Cr, Cu, Ni, Pb, Sb, Tl, U, V and Zn was determined by inductively coupled plasma mass spectrometry (ICP–MS). The data were used to calculate the health risk index (HRI) for EVOOs and the geoaccumulation index (Igeo) and potential ecological risk index (PERI) for soils.ResultsAnalytical data suggested that the PTE concentrations in the investigated olive grove soils are natural as comparable to their normal geochemical background in soils from Southern Tuscany formed from the same parent rocks of Valdichiana Senese soils or due to local geogenic enrichments in some parent rocks. Among the analysed PTEs in the EVOO samples, Zn, Cu and Ni had the highest concentrations, followed by Cr and Pb. Most PTEs showed a high variability of their concentrations in EVOOs from Valdichiana Senese.ConclusionOn the basis of values of indices applied to PTE concentrations in the soil samples, a low‐to‐moderate Cu contamination emerged only in the olive grove soils of two farms, probably as a consequence of the diffuse use of Cu‐based products in agriculture, and overall, the ecological risk was low. Furthermore, although EVOOs from Valdichiana Senese have somewhat slightly high concentrations of some PTEs such as Cu and Zn, the health risk associated with their intake through the EVOO consumption is definitely negligible.
Evaluation of Agave salmiana by‐products as a functional ingredient for the development of sustainable foods
Authors: Márquez‐Rangel Isabel , Cruz Mario , Ruiz Héctor A , Rodríguez‐Jasso Rosa M , Loredo‐Treviño Araceli , Belmares Ruth 
Published: February 2025

AbstractBACKGROUNDThe generation of agro‐industrial wastes and strategies to reduce the environmental and economic impacts that this problem generates has aroused interest in the use of lignocellulosic wastes to promote food sustainability. These wastes are rich in polysaccharides, and their addition can affect the physicochemical characteristics of bakery food. In this study, agave wastes were evaluated at different substitution levels (0%, 10%, 20%, and 30%, w/w) in wheat flour to determine their nutritional, techno‐functional, and thermal qualities.RESULTSThere was an improvement in the proximal chemical composition in the flour blends, mainly in crude fiber (0.01%, 0.47%, 0.80%, and 1.70%, respectively). This also resulted in differences in the coloration (ΔE; 0, 12.43, 21.05, and 24.22) owing to the brown color of agave powder. An increase in water holding capacity was obtained (1.29, 1.44, 1.52, and 1.69%), while oil holding capacity presented a decrease (1.59%, 1.38%, 1.36%, and 1.33%). Viscosities were significantly affected by the addition of agave. However, the final viscosity (3195.67, 2573.33, 2430, and 2107.33 cP) suggested that the maximum level of substitution was 20%. Thermal properties indicated a decrease in the heat capacity required for starch gelatinization (39.45, 36.36, 35.33, and 34.47 J g−1) due to its partial substitution.CONCLUSIONThis study suggests that non‐conventional fiber obtained from agave waste can be incorporated into conventional flours such as wheat flour for food development within the concept of a circular economy, which is an option for the functional improvement of food from wheat and valorizing wastes of economic importance. © 2025 Society of Chemical Industry.
A Scoping Review of the Oral Treatment Options for the Management of Detrusor Sphincter Dyssynergia
Authors: Tousignant Angélique , Blais Marc‐Antoine , Tu Le Mai , Morin Mélanie , Ismail Salima 
Published: February 2025

ABSTRACTBackgroundAdult neurogenic lower urinary tract dysfunction may be associated with detrusor sphincter dyssynergia (DSD). Given the sparsity of the literature and the absence of official guidelines regarding the use of oral medications in the management of DSD, this scoping review aims to critically assess the available evidence to guide future research and practice.MethodsWe conducted a systematic scoping review of articles published from 1950 to July 2023 using PubMed, MedLine, Scopus and CINAHL databases to assess all oral treatment options for DSD. All study designs were included. The search was limited to English and French literature regarding human patients over 18 years of age with DSD.ResultsOf the 899 records screened, 15 studies were included, involving a total of 257 participants. Alpha‐adrenergic blockers, nitric oxyde and muscle relaxants have been used in the treatment of DSD. A decrease of postvoid residual volumes and an improvement of symptom scores as well as urine flow rates were reported in several studies. Regarding the alpha‐adrenergic blockers, five of the six studies that detailed postvoid residual volumes and subjective improvement noted benefits in most patients. Additionally, two of the three studies that addressed mean flow rate observed improvements in most patients. All six studies that documented adverse effects found side effects in only a slight minority of patients.ConclusionsAlpha‐adrenergic blockers are promising, but there is lacking evidence on the oral treatment of DSD. This study highlights the importance of conducting more studies to draw solid conclusions and stop treating these patients empirically.