bluuebunny/crossref_metadata_2025_split huggingface dataset:
Relationship between vitamin D receptor genotypes (FOK1rs2228570) and IL18 gene expression in sample of multiple sclerosis Iraqi patients
Authors: Lafi* and Zahraa Kadhim , Mohammed Bushra Jasim 
Published: February 2024

BACKGROUND: Multiple Sclerosis known as MS, this chronic inflammatory demyelinating condition affects the nervous system. It is a heterogenic and multifactorial disease. The goal of the current study was to investigate the relationship between MS patients’ IL18 gene expression and the vitamin D receptor gene polymorphism (FOK1rs2228570). OBJECTIVE: The aim of the study to investigate the association of vitamin D receptor (FOK1rs2228570) gene polymorphism and pro inflammatory cytokine (IL18) gene expression among multiple sclerosis Iraqi patients. Detection VDR polymorphism and determine whether this SNP is involved in susceptibility to multiple sclerosis and estimation IL18 gene expression and explore its relation with multiple sclerosis susceptibility. METHODS: Blood samples were taken from 75 MS patients in Iraq (30 men and 45 women), as well as from 75 volunteers who seemed to be in a favorable state of health and fell within the age range of 20 to 50 years. Tetra-ARMS Polymerase Chain Reaction (Tetra-ARMS PCR) was used to find polymorphisms in the vitamin D receptor (VDR) gene, and Real-time Polymerase Chain Reaction (RT-PCR) was used to measure IL18 gene expression. RESULTS: The findings from the analysis of VDR gene polymorphism in patients with MS indicated that the wild-type genotype T/T was present in 8 individuals, accounting for 10.6%, the heterogeneous genotype TC was 36 (48%), and the homogeneous genotype CC was 31 (41.3%), whilst T allele frequency was 52(34.6%) and C allele was 98(65.3%) with (P⩽ 0.01) significant difference and even as in control T/T genotype was 49(65.3%), TC genotype was 21(28%), CC genotype was 5(6.66%), T allele frequency was 119(79.3%) and C allele was 31(20.6%) with significant difference (P⩽ 0.001). While estimation of IL18 expression showed high elevation in patients’ group (2.59 ± 0.51 fold) by significance difference (P⩽ 0.5) when compared to control group (1.35 ± 0.14 fold). The relationship between IL18 gene expression with VDR variant in MS patients demonstrated a significant rise (2.9 ± 0.51 fold) at CC genotype patients in IL18 folding gene expression, followed by (4.6 ± 0.17 fold) in TC genotype patients and finally (1.4 ± 0.08 fold) in TT genotype patients with highly significant (P⩽ 0.01). CONCLUSION: The VDR(FOK1rs2228570) genotype was significantly correlated with IL18 expression in MS patients from Iraq.
Effect of physical exercise on inactivated COVID-19 vaccine antibody response in the elderly
Authors: Şevgin Ömer , Özer Songül 
Published: February 2024

BACKGROUND: Physical exercise has been proposed as a new alternative to chemical adjuvants. OBJECTIVE: To investigate the relationship between regular exercise and post-vaccination antibody response in the elderly. METHODS: The study was conducted with the elderly over the age of 65. 30 participants we randomized into 2 groups and divided into exercise and control groups. The experimental group received a 12-week exercise program. The control group was followed up without any exercise. The day on which the second dose of the vaccine was administered to all participants was considered day 0. The antibody level in the serum samples was taken 15 days and 12 weeks after the vaccination. The antibody concentration was measured after the second dose of vaccination. RESULTS: The mean antibody level in the control group was 69.4 U/ml and 56.4 U/ml 15 days and 12 weeks after the second vaccination. The mean antibody level in the exercise group was 74 U/ml and 71.6 U/ml 15 days and 12 weeks after the second vaccination. CONCLUSIONS: Regular exercise of light to moderate intensity may increase post-vaccination antibody response in the elderly. Therefore, exercise can be used as a behavioral adjuvant to improve the vaccine efficacy in the elderly.
Perkawinan Beda Agama Pada Penghayat Kepercayaan Sunda Wiwitan Ditinjau Dari Hukum Islam Dan Undang-Undang Perkawinan
Authors: Drajat Muhammad Rifqi Rafi , Utami Vidya Khairina 
Published: February 2024

Ikatan lahir dan batin yang dilakukan oleh sepasang perempuan dan laki-laki dengan adanya tujuan mempunyai keturunan disebut perkawinan. Undang-Undang Perkawinan mengatur bahwasanya Sah nya perkawinan mesti diadakan berdasarkan aturan kepercayaan atau agama yang dianut. Sunda Wiwitan sebagai sebuah kepercayaanÂ mempunyai iman untuk tidak melarang terjadinya perkawinan bagi pasangan yang berlainan keyakinan. Tujuan dari penelitian ini ialah guna melihat aktualisasi dari sahnya perkawinan beda agama antara agama Islam dengan penghayat kepercayaan Sunda Wiwitan dan akibat hukum yang ditimbulkan. Metode penelitian yang dipakai ialah metode analisis yuridis kualitatif, yakni menggabungkan data sekunder berdasarkan peraturan perundang-undangan dan data primer hasil wawancara di daerah asli kepercayaan Sunda Wiwitan. Berdasarkan hasil penelitian pertama, status keabsahan perkawinan beda agama pada penganut Islam dengan Sunda Wiwitan ialah tidak sah secara hukum agama Islam, tetapi sah menurut aturan kepercayaan Sunda Wiwitan dan Undang-Undang Perkawinan sebagai hukum negara. Kedua, mengenai akibat hukum yang ditimbulkan adalah hukum Islam sudut pandangnya berbeda dengan Undang-Undang Perkawinan, yang dimana secara kedudukan anak menjadi anak hasil Zina danÂ pewarisan yang dilakukan juga akan berdasarkan dari garis keturunan ibu, sedangkan dalam Undang-Undang Perkawinan memandang bahwasanya anak yang dihasilkan ialah anak yang berada di luar perkawinan di mata negara dan sebagai ahli waris akan mengikuti garis ibu.
Pemberdayaan Usaha Mikro kecil Menengah Gipang Magelaran Cilik Kota Serang Berbasis Pelestarian Resep Turun Temurun Dalam Menunjang Perekonomian
Authors: Purwaningsih Endang , Basrowi Basrowi 
Published: February 2024

Magelaran Cilik merupakan suatu kampung terletak di Kota Serang, dengan keunikan nama kelurahannya yakni kelurahan Masjid Priyayi. Banyak pelaku UMKM makanan tradisional layaknya home industry, dan mengolah makanan dengan cara konvensional, begitu pula dengan manajemen dan pemasarannya. Penelitian ini termasuk dalam penelitian normatif terapan yakni menggabungkan data sekunder dengan hasil pengamatan dan wawancara dengan narasumber yang berhubungan dengan objek penelitianÂ serta mencarikan solusi hukumnya, dalam hal ini pemerintah kelurahan Masjid Priyayi, Tetua UMKM Magelaran Cilik sekaligus sebagai Ketua Koperasi, serta pelaku UMKM sendiri. Hasil penelitian menunjukkan bahwa pemberdayaan pelaku UMKM Magelaran Cilik yang dilakukan adalah meningkatkan peran koperasi dalam membantu memperoleh bahan baku, dan dinas terkait yang selama ini berbentuk bantuan fasilitasi program pelatihan dan beberapa perolehan legalitas. Kendala yang dihadapi adalah permodalan, digital marketing dan inovasi produk. Perlindungan resep turun temurun dilakukan guna melestarikan warisan nenek moyang, menjadi kunci dalam setiap memproduksi. Inovasi produk belum banyak dilakukan, termasuk varian rasa, resep baru maupun desain.
FAKTOR RISIKO INTRAPERSONAL NYERI PINGGANG BAWAH PADA PERAWAT DI TEMPAT KERJA: SYSTEMATICAL REVIEW
Authors: Astuti Martha Sri 
Published: February 2024

Prevalensi nyeri punggung (NPB) bawah dari tahun 2008-2019 tetap berkisar 14% hingga 90%. Penyebab utamanya adalah posisi yang tidak ergonomis. Posisi kerja professional perawat yang tidak ergonomis menyebabkannya mempunyai risiko tinggi. Sebagian NPB berlangsung lebih lama dan kronis. Nyeri kronis secara individu dipengaruhi faktor psikologis, lingkungan dan lainnya. Diperlukan penelitian untuk mendapatkan faktor risiko NPB pada perawat di tempat kerja. Tujuan penelitian ini untuk mengidentifikan faktor risiko intrapersonal nyeri pinggang bawah pada perawat di tempat kerja. Metode penelitian adalah systematic review. Penelitian menggunakan checklist Preferred Reporting Items for Systemic Review and Meta Analysis (PRISMA). Pencarian sistematis dengan kata kunci pencarian low back pain, ners, RCT, Quasi-experimental, Qualitative analysis dan Prospective longitudinal study dalam kurun waktu tahun 2013-2022 dicari di Science Direct, Medline, Pubmed, dan Proquest. Hasil penelitian dari 24 penelitian yang terjaring didapatkan 13 faktor risiko intrapersonal, terdiri dari 2 yang tidak bisa diubah (usia dan jenis kelamin) dan 11 yang bisa diubah (BMI, pengetahuan ergonomic, pengetahuan NPB, NPB sebelumnya, Riwayat operasi, keyakinan kerja yang menyebabkan sakit, stress, kelelahan, insomnia, kepuasan kerja, dan pengalaman kerja). Kesimpulan penelitian didapatkan 13 faktor risiko intrapersonal pada perawat di tempat kerja. Hasil ini bisa dijadikan dasar program promotive NPB pada perawat untuk menurunkan prevalensi NPB pada perawat.
HAK ATAS INFORMASITERHADAP PERLINDUNGAN HUKUMBAGI KONSUMEN DALAM JUAL BELIONLINE MELALUI LAZADA
Authors: Wardiono Kelik , Firmansyah Ifan 
Published: February 2024

Penelitian ini bertujuan untuk mendeskripsikan konsumen atas hak informasi dalam tranksaksi jual beli online pada E-Commerce Lazada, penelitian ini menggunakan metode yuridis normatif dengan pendekatan secara library research dan statute approach. Sumber data dalam penelitian ini berupa data sekunder yang terdiri dari informasi barang yang diperjualbelikan oleh pelaku usaha pada E-Commerce Lazada. Data yang diperoleh melalui studi kepustakaan tersebut, setelah diolah, dianalisis secara kualitatif dengan menggunakan metode logika deduktif. Berdasarkan dari pembahasan yang dilakukan dapat diketahui bahwa informasi yang terdapat di E-Commerce Lazada belum memberikan perlindungan konsumen, hal ini dikarenakan masih banyak pelaku usaha yang memberikan informasi bertentangan dengan peraturan perlindungan konsumen seperti informasi yang tidak benar, tidak ada jaminan ganti rugi kepada konsumen, fisik barang yang tidak sesuai informasi, serta informasi yang diberikan tidak lengkap.
Exploring the relationship between intestinal microbiota and immune checkpoint inhibitors in the treatment of non-small cell lung cancer: insights from the “lung and large intestine stand in exterior-interior relationship” theory
Authors: Li Luwei , Zhong Hongmei , Wang Yajie , Pan Zongying , Xu Shumei , Li Shuai , Zeng Guilin , Zhang Weiwei , Li Jie , He Lang 
Published: February 2024

ObjectiveThis study is aim to discern the Traditional Chinese Medicine (TCM) syndrome classifications relevant to immunotherapy sensitive in non-small cell lung cancer (NSCLC) patients, and to delineate intestinal microbiota biomarkers and impact that wield influence over the efficacy of NSCLC immunotherapy, grounded in the TCM theory of “lung and large intestine stand in exterior-interior relationship.”MethodsThe study cohort consisted of patients with advanced NSCLC who received treatment at the Oncology Department of Chengdu Fifth People’s Hospital. These patients were categorized into distinct TCM syndrome types and subsequently administered immune checkpoint inhibitors (ICIs), specifically PD-1 inhibitors. Stool specimens were collected from patients both prior to and following treatment. To scrutinize the differences in microbial gene sequences and species of the intestinal microbiota, 16S rRNA amplicon sequencing technology was employed. Additionally, peripheral blood samples were collected, and the analysis encompassed the assessment of T lymphocyte subsets and myeloid suppressor cell subsets via flow cytometry. Subsequently, alterations in the immune microenvironment pre- and post-treatment were thoroughly analyzed.ResultsThe predominant clinical manifestations of advanced NSCLC patients encompassed spleen-lung Qi deficiency syndrome and Qi-Yin deficiency syndrome. Notably, the latter exhibited enhanced responsiveness to ICIs with a discernible amelioration of the immune microenvironment. Following ICIs treatment, significant variations in microbial abundance were identified among the three strains: Clostridia, Lachnospiraceae, and Lachnospirales, with a mutual dependency relationship. In the subset of patients manifesting positive PD-L1 expression and enduring therapeutic benefits, the study recorded marked increases in the ratios of CD3+%, CD4+%, and CD4+/CD8+ within the T lymphocyte subsets. Conversely, reductions were observed in the ratios of CD8%, Treg/CD4+, M-MDSC/MDSC, and G-MDSC/MDSC.ConclusionThe strains Clostridia, Lachnospiraceae, and Lachnospirales emerge as potential biomarkers denoting the composition of the intestinal microbiota in the NSCLC therapy. The immunotherapy efficacy of ICIs markedly accentuates in patients displaying durable treatment benefits and those expressing positive PD-L1.
Preserved C-peptide is common and associated with higher time in range in Chinese type 1 diabetes
Authors: Liu Wei , Fang Yayu , Cai Xiaoling , Zhu Yu , Zhang Mingxia , Han Xueyao , Li Juan , Yin Sai , Cai Deheng , Chen Jing , Wang Lei , Shi Dawei , Ji Linong 
Published: February 2024

ObjectiveThe aim of this study is to determine the residual C-peptide level and to explore the clinical significance of preserved C-peptide secretion in glycemic control in Chinese individuals with type 1 diabetes (T1D).Research design and methodsA total of 534 participants with T1D were enrolled and divided into two groups, low–C-peptide group (fasting C-peptide ≤10 pmol/L) and preserved–C-peptide group (fasting C-peptide &gt;10 pmol/L), and clinical factors were compared between the two groups. In 174 participants who were followed, factors associated with C-peptide loss were also identified by Cox regression. In addition, glucose metrics derived from intermittently scanned continuous glucose monitoring were compared between individuals with low C-peptide and those with preserved C-peptide in 178 participants.ResultsThe lack of preserved C-peptide was associated with longer diabetes duration, glutamic acid decarboxylase autoantibody, and higher daily insulin doses, after adjustment {OR, 1.10 [interquartile range (IQR), 1.06–1.14]; OR, 0.46 (IQR, 0.27–0.77); OR, 1.04 (IQR, 1.02–1.06)}. In the longitudinal analysis, the percentages of individuals with preserved C-peptide were 71.4%, 56.8%, 71.7%, 62.5%, and 22.2% over 5 years of follow-up. Preserved C-peptide was also associated with higher time in range after adjustment of diabetes duration [62.4 (IQR, 47.3–76.6) vs. 50.3 (IQR, 36.2–63.0) %, adjusted P = 0.003].ConclusionsOur results indicate that a high proportion of Chinese patients with T1D had preserved C-peptide secretion. Meanwhile, residual C-peptide was associated with favorable glycemic control, suggesting the importance of research on adjunctive therapy to maintain β-cell function in T1D.
Sex-specific differences in the associations between adiposity indices and incident hyperuricemia among middle-aged and older adults: a nationwide longitudinal study
Authors: Liu Zhiyi , Zhou Qinwu , Tang Yuqiong , Li Jiyong , Chen Qiutong , Yang Hongguang , Zhou Shuhan 
Published: February 2024

ObjectiveAlthough obesity is a known risk for hyperuricemia (HUA), the associations between adiposity indices and incident HUA and whether sex-specific differences exist is still unknown. We aimed to investigate the associations between adiposity indices and incident HUA in a longitudinal study.MethodsData from the China Health and Retirement Longitudinal Study (CHARLS) in 2011–2012 and 2015–2016 were used to conduct a cohort study. Participants aged ≥45 years without HUA at baseline were included in this study. Adiposity indices, including body mass index (BMI), waist circumference (WC), waist-to-height ratio body roundness index (BRI), conicity index (CI), lipid accumulation product (LAP) index, waist-to-height ratio (WHtR), visceral adiposity index (VAI), and Chinese visceral adiposity index (CVAI), were calculated. Logistic analysis was used to analyze the association between adiposity indices and incident HUA risk stratified by gender. Receiver operating characteristic curve analysis was performed to evaluate the power of predictions for incident HUA.ResultsOf 5,873 participants aged 59.0 ± 8.7 years enrolled in this study, 578 (9.8%) participants developed HUA during the 4-year follow-up period. After adjusting for confounding variables, LAP, VAI, and CVAI showed significant association with incident HUA. BMI, WC, WHtR, BRI, and CI were significantly associated with incident HUA in women but not in men. LAP had the highest area under the curve (AUC) (0.612) followed by CVAI (0.596) in men, while CVAI had the highest AUC (0.707) followed by LAP (0.691) in women. All indices showed better predictive ability in women than in men.ConclusionOur findings indicated that adiposity indices were effective predictors of incident HUA and showed better predictive power in women than men. In clinical practice, adiposity indices could be used to assess and prevent incident HUA among Chinese middle-aged and older adults.
Association between the ZJU index and risk of new-onset non-alcoholic fatty liver disease in non-obese participants: a Chinese longitudinal prospective cohort study
Authors: Zheng Keyang , Yin Yuzhe , Guo Hang , Ma Linlin , Liu Rufei , Zhao Tianzhu , Wei Yuxuan , Zhao Zixu , Cheng Wenli 
Published: February 2024

BackgroundNon-alcoholic fatty liver disease (NAFLD) is increasingly observed in non-obese individuals. The ZJU (Zhejiang University) index has been established as a new and efficient tool for detecting NAFLD, but the relationship between the ZJU index and NAFLD within non-obese individuals still remains unclear.MethodsA post-hoc evaluation was undertaken using data from a health assessment database by the Wenzhou Medical Center. The participants were divided into four groups based on the quartile of the ZJU Index. Cox proportional hazards regression, Kaplan-Meier analysis and tests for linear trends were used to evaluate the relationship between the ZJU index and NAFLD incidence. Subgroup analysis was conducted to test the consistency of the correlation between ZJU and NAFLD in subsgroups. Receiver operative characteristic (ROC) curve analysis was performed to evaluate the predictive performance of the ZJU index, compared with the Atherogenic index of plasma (AIP) and Remnant lipoprotein cholesterol (RLP-C) index.ResultsA total of 12,127 were included in this study, and 2,147 participants (17.7%) developed NAFLD in 5 years follow-up. Participants in higher ZJU quartiles tended to be female and have higher liver enzymes (including ALP, GGT, ALT, AST), GLU, TC, TG, LDL and higher NAFLD risk. Hazard Ratios (HR) and 95% confidence intervals (CI) for new-onset NAFLD in Q2, Q3, and Q4 were 3.67(2.43 to 5.55), 9.82(6.67 to 14.45), and 21.67(14.82 to 31.69) respectively in the fully adjusted model 3. With increased ZJU index, the cumulative new-onset NAFLD gradually increased. Significant linear associations were observed between the ZJU index and new-onset NAFLD (p for trend all&lt;0.001). In the subgroup analysis, we noted a significant interaction in sex, with HRs of 3.27 (2.81, 3.80) in female and 2.41 (2.21, 2.63) in male (P for interaction&lt;0.01). The ZJU index outperformed other indices with an area under the curve (AUC) of 0.823, followed by AIP (AUC=0.747) and RLP-C (AUC=0.668).ConclusionThe ZJU index emerges as a promising tool for predicting NAFLD risk in non-obese individuals, outperforming other existing parameters including AIP and RLP-C. This could potentially aid in early detection and intervention in this specific demographic.
Empirical and numerical-based predictive analysis of a single-axis PV system under semi-arid climate conditions of Pakistan
Authors: Saeed Farwa , Ghafoor Abdul , Hussain Muhammad Imtiaz , Ikram Kamran , Faheem Muhammad , Shahzad Muhammad , Amjad Waseem , Omar Muhammad Mubashar , Lee Gwi Hyun 
Published: February 2024

Power generation from fossil fuels is the biggest challenge in the next half of the century. Alternative power generation techniques such as solar photovoltaic (PV) show potential to act as a future fuel with a challenge to efficiently convert the harvested solar energy into electrical power. This investigation conclusively focused on setting a 2.160-kW solar PV system capable of working at a higher efficiency by developing a mechanical structure that optimizes power production and minimizes energy losses. In addition to that, solar PV system efficiencies at various tracking positions, performance coefficients during rainy and sunny days, and system degradation rates have also been investigated. The PVsyst v6.8 simulation tool was used to obtain the simulated results, which were compared with the actual experimental results. The parameters considered for the investigations include ambient temperature, irradiance, solar PV module surface temperature, solar PV voltage and current, wind velocity, and atmospheric turbidity. The solar PV system was evaluated based on two modes, namely, M1 (no tracking/fixed type) and M2 (manual tracking by changing the position of the solar PV system every hour). The predictive results obtained using PVsyst v6.8 concluded that total energy production from the installed system was 3,242 kWh/yr and 3,984 kWh/yr for M1 and M2, respectively. The performance ratio (PR), obtained from simulation, was 72% and 78% for M1 and M2, respectively, which was consistent with the experimental results, i.e., 70% and 72% for M1 and M2, respectively. Similarly, the power conversion efficiencies under standard temperature and conditions for both modes, simulated and experimental, were found to be 16.50% and 12.75%, respectively. The estimated degradation rate was observed in the range of −0.6% to −5.0%.
AIRR-C IG Reference Sets: curated sets of immunoglobulin heavy and light chain germline genes
Authors: Collins Andrew M. , Ohlin Mats , Corcoran Martin , Heather James M. , Ralph Duncan , Law Mansun , Martínez-Barnetche Jesus , Ye Jian , Richardson Eve , Gibson William S. , Rodriguez Oscar L. , Peres Ayelet , Yaari Gur , Watson Corey T. , Lees William D. 
Published: February 2024

IntroductionAnalysis of an individual’s immunoglobulin (IG) gene repertoire requires the use of high-quality germline gene reference sets. When sets only contain alleles supported by strong evidence, AIRR sequencing (AIRR-seq) data analysis is more accurate and studies of the evolution of IG genes, their allelic variants and the expressed immune repertoire is therefore facilitated.MethodsThe Adaptive Immune Receptor Repertoire Community (AIRR-C) IG Reference Sets have been developed by including only human IG heavy and light chain alleles that have been confirmed by evidence from multiple high-quality sources. To further improve AIRR-seq analysis, some alleles have been extended to deal with short 3’ or 5’ truncations that can lead them to be overlooked by alignment utilities. To avoid other challenges for analysis programs, exact paralogs (e.g. IGHV1-69*01 and IGHV1-69D*01) are only represented once in each set, though alternative sequence names are noted in accompanying metadata.Results and discussionThe Reference Sets include less than half the previously recognised IG alleles (e.g. just 198 IGHV sequences), and also include a number of novel alleles: 8 IGHV alleles, 2 IGKV alleles and 5 IGLV alleles. Despite their smaller sizes, erroneous calls were eliminated, and excellent coverage was achieved when a set of repertoires comprising over 4 million V(D)J rearrangements from 99 individuals were analyzed using the Sets. The version-tracked AIRR-C IG Reference Sets are freely available at the OGRDB website (https://ogrdb.airr-community.org/germline_sets/Human) and will be regularly updated to include newly observed and previously reported sequences that can be confirmed by new high-quality data.