bluuebunny/crossref_metadata_2025_split huggingface dataset:
HIF1α/MIF/CD74 signaling mediated OSA-induced atrial fibrillation by promoting M1 macrophages polarization
Authors: He Hangyuan , Zhang Lin , Lu Zhengjie , Li Bin , Li Xufei 
Published: February 2024

Abstract
Obstructive sleep apnea (OSA) is known to contribute to the increased occurrence and recurrence of atrial fibrillation (AF). However, the mechanism of chronic OSA-induced AF remains unknown. We constructed a rat model of chronic OSA and found that chronic OSA altered the pathological phenotype of atrial myocardial tissues, rendering it more susceptible to AF. Furthermore, we observed that chronic OSA promoted the polarization of M1 macrophages in the atrial tissue of rats, and the AF susceptibility induced by chronic OSA was reversed upon clearance of macrophages. Then, we found that macrophages induced an atrial fibrillation-like phenotype in atrial myocytes, while atrial myocytes promoted M1 polarization of macrophages, under hypoxia/reoxygenation treatment in vitro. Moreover, hypoxia/reoxygenation upregulated the expression of hypoxia-inducible factor 1-alpha (HIF1α) in atrial myocytes, which subsequently stimulated the transcription and expression of macrophage migration inhibitory factor (MIF) by binding to the promoter region of the MIF gene. The increased expression of MIF in atrial myocytes further activated the expression of nuclear factor-kappa B (NF-κB) through interaction with the macrophage surface receptor CD74, ultimately leading to M1 macrophages polarization. In summary, chronic OSA activated M1 macrophage polarization through the HIF1α/MIF/CD74 signaling pathway, thereby mediating the increased susceptibility to AF. This study offers novel insights into early prevention strategies and potential therapeutic targets for OSA-induced AF.
Extraction of bioactive compounds from Rubus idaeus bioresidues: a full screening on phenolic composition and bioactive potential
Authors: Plasencia Paula , Finimundy Tiane C. , Carocho Márcio , Calhelha Ricardo , Añibarro-Ortega Mikel , Pires Tânia C.S.P. , Barreiro Filomena , Garcia Pablo A. , Barros Lillian , Heleno Sandrina A. 
Published: February 2024

Abstract

Purpose: Rubus idaeus cultivation has boosted productivity due to its high nutritional value. In consequence, waste production increased. The discarded biomass, including leaves and aerial components, can be transformed into valuable functional ingredients for industrial applications, such as cosmetics. Studying their bioactivity potential is of high relevance.
Methods: According to the present idea, the research involved the extraction of phenolic compounds from raspberry plant branches and leaves by employing four different techniques, namely aqueous decoction, aqueous infusion, hydroethanolic maceration, and ultrasound-assisted extraction (UAE). Subsequently, these compounds were screened for their bioactive potential, including antioxidant, antibacterial, anti-inflammatory, and cytotoxic properties.
Results: The UAE-assisted extraction has yielded extracts with more phenolic compounds, while the infusion and maceration result in higher contents of flavonols. Among the identified phenolic compounds, hydrolysable tannins, particularly galloyl-bis-HHDP-glucose, were found to be the most dominant ones. Regarding antioxidant potential, the decoction extract was the strongest, while the infusion showed the greatest potential for inhibiting lipid peroxidation. The UAE extract was found to be highly effective as an antibacterial agent. Both infusion and UAE extracts demonstrated the highest anti-inflammatory potential.
Conclusion: The combination of these results highlights the sample's bioactive potential and the importance of exploiting bioresidues as unique, sustainable candidates for industrial applications.
Determinants of secondary traumatic stress in midwives: The role of workplace related factors
Authors: Hajiesmaello Maryam , Hajian Sepideh , Riazi Hedyeh , Majd Hamid Alavi , Yavarian Roya 
Published: February 2024

Abstract
Background: Secondary traumatic stress (STS) in midwives is a significant issue that can lead to emotional damage and negatively impacts maternal-newborn care. This study aimed to determine the frequency and severity of STS and its determinants among midwives working in the labor and delivery departments of West Azerbaijan, Iran.
Research method: This cross-sectional analytical study included all midwives working in labor and delivery departments in 18 hospitals and four delivery facilities with rural midwifery services. Data was collected using demographic information questionnaires, the Secondary Traumatic Stress Scale, and some job-related questionnaires. Statistical tests, including analysis of variance and multiple linear regression using SPSS software version 23 and path analysis test using Amos software version 24, were applied to analyze the direct and indirect determinants of STS incidence.
Findings: The 349 participants had a mean 6.88±6.44 years of work experience. Of the participants, 45% experienced mild to high degrees, and 37.5% experienced severe STS. The results of the path analysis showed that the desire to continue working in the midwifery profession had a direct protective effect on the occurrence of STS (β = 0.184, p = 0.009). Conversely, psychological injuries caused by adverse behavior and violence at work ( β = 0.361, p = 0.007) and job burnout (β = 0.260 , p = 0.003), had an increasing effect on the incidence of STS, both directly and indirectly.
Conclusion: In addition to traumatic events, factors related to the work environment can contribute to the development of STS in midwives.
Cohort profile: IDcare – a longitudinal register study of pre-pandemic and pandemic health care utilization and diagnostic profiles among people with intellectual disabilities in southern Sweden
Authors: Sandberg Magnus , Kristensson Jimmie , Axmon Anna 
Published: February 2024

Abstract

Purpose: The aim of this study and creation of this cohort was to investigate patterns of health and health care utilisation before and during the COVID-19 pandemic among people with intellectual disabilities (ID) compared to the general population.
Participants: People living in Skåne, the southernmost region of Sweden, on 1st of January 2014 and with at least one diagnosis of ID (ICD-10 codes F70-F79) or Down syndrome (DS; Q90), or support and/or services according to the LSS act in 2014- 2021 comprised the ID cohort (n=14 716). People living in the same family and/or household as a person in the ID cohort constituted the ID family cohort (n=26 344), and those remaining comprised the general population cohort (gPop; n=1 232 299).
Findings to date: Data has been collected for all three cohorts from several national and regional registers, including registers for health care utilization (2014-2021), deaths (2014-2021), COVID-19-related health care (vaccinations, intensive care, palliative care, 2020-2021). The prevalence of ID was 1.2%. In the ID cohort, 77.9% had at least one measure of support, 5.8% at least one Q90-diagnosis and 63.8% had at least one F7-diagnosis (26.9% mild (F70), 7.4% moderate (F71), 2.8% severe (F72), 1.4% profound (F73), and 25.4% other/unknown (F78/F79)). Compared to the gPop there were more people in the younger age groups in the ID cohort.
Future plans: At this point, no additional collection of data will be carried out. However, there is a possibility to add data from the registers to include years after 2021 or from additional registers. Future publications will explore relevant research questions and report key findings in relation to health among people with ID. Future results will be used to inform policy and practice on people with ID.
A New Retractor Minimizes Muscle Damage and Reduces Total Hip Arthroplasty-related Inflammatory Response via Direct Anterior Approach
Authors: Cai Shenghao , Chen Qirui , Xia Yong , Zhou Bin , Hu Shen , Fu Xiaoling 
Published: February 2024

Abstract
Background
Total hip arthroplasty (THA) is the most effective treatment for severe hip disease. Orthopedic surgeons prefer using the Direct Anterior Approach (DAA) technique for THA as it is muscle-sparing and less invasive for the hip joint. It is noted that muscular damage, especially to the tensor fascia lata muscle (TFLM), elicits an inflammatory response, negating DAA's beneficial effects. To prevent damage to the TFLM and reduce inflammation during surgical procedures, a specialized retractor was explicitly developed and intended for use during the operation.
Purpose
To investigate whether the new retractor may reduce muscle injury and post-operative inflammation.
Methods
Fifty-six patients undergoing DAA-based THA were randomly divided into two groups. The observation group used the new retractor to prevent muscle strain during femur lifting. In the control group, gauze was the only protection during the surgery. The two groups were compared over time by measuring their C-reactive protein (CRP), interleukin-6 (IL-6), and creatine kinase (CK) serum levels. The Harris hip score and the visual analog scale (VAS) were used to assess the difference between the two groups.
Result
No significant differences were found in the CRP, IL-6, and CK pre-operative levels. Moreover, the observation group exhibited significantly lower serum levels of the tested parameters than the control group on days 1, 3, and 5 post-operation (p < 0.05). Additionally, the VAS score in the control group was significantly lower than in group A (p < 0.05). A month post-surgery, the Harris score of the control group exhibited a significantly greater value than the observation group (p < 0.05). However, no significant differences were observed at 3 and 6 months post-surgery.
Conclusion
Utilizing the self-designed retractor system in DAA THA mitigates the risk of muscle damage and reduces the extent of post-operative inflammatory reaction.
Design of novel HIV-1 protease inhibitors with favorable oral properties using a virtual screening and lead optimization approach
Authors: Alchab Faten , Alshekh Ali , Rajab Maya 
Published: February 2024

Abstract
Acquired Immunodeficiency Syndrome (AIDS) is a chronic and potentially fatal transmissible disease caused by the Human Immunodeficiency Virus (HIV). Since its discovery in 1981, an estimated 85 million cases and 40 million AIDS related deaths have occurred worldwide. Among the two types of HIV, HIV-1 accounts for over 90% of reported cases. Throughout the years, multiple drugs have been approved for the treatment of AIDS. However, these drugs face many drawbacks such as toxic side effects, non-optimal pharmacokinetic profile and drug resistance due to virus mutation. This study aims to design novel potent HIV-1 protease inhibitors that overcome these drawbacks through molecular modelling methods. Pubchem database was screened for potential lead compounds. Results were filtered through two phases of ADMET and docking studies. Finally, the chosen lead compound was optimized through fragment replacement to obtain the novel inhibitors. Scientific contribution: This study aims to employ an in-silico virtual screening and lead optimization workflow, in order to design potential HIV-1 protease inhibitors which build upon the strengths, and overcome some of the most prominent obstacles facing current approved anti-HIV medication, including drug resistance, toxic side effects and low reachability to viral reservoirs such as the central nervous system.
ChatGPT Usage and Attitudes are Driven by Perceptions of Usefulness, Ease of Use, Risks, and Psycho-Social Impact: A Study among University Students in the UAE
Authors: Sallam Malik , Elsayed Walid , Al-Shorbagy Muhammad , Barakat Muna , Khatib Sami EL , Ghach Wissam , Alwan Nisreen , Hallit Souheil , Malaeb Diana 
Published: February 2024

Abstract
Background
The use of ChatGPT among university students has gained popularity. The current study aimed to assess the factors driving the attitude and usage of ChatGPT as an example of generative artificial intelligence among university students in the United Arab Emirates (UAE).
Methods
This cross-sectional study was based on a previously validated technology acceptance model (TAM)-based survey instrument termed TAME-ChatGPT. The self-administered e-survey was distributed by emails for students enrolled in UAE universities during September–December 2023 using a convenience-based approach. Assessment of the demographic, academic, and TAME-ChatGPT constructs role in ChatGPT attitude and usage was conducted using univariate followed by multivariate analyses.
Results
The final study sample comprised 608 participants, 91.0% of which heard of ChatGPT while 85.4% used ChatGPT before the study. Univariate analysis indicated that positive attitude to ChatGPT was associated with the three ChatGPT attitude constructs namely lower perceived risks, lower anxiety, and higher scores on the attitude to technology/social influence. For the ChatGPT usage, univariate analysis indicated that positive attitude to use was associated with being male, Arab in nationality, and lower point grade average as well as the four ChatGPT usage constructs namely higher perceived usefulness, lower perceived risks of use, higher scores on the behavior/cognitive construct and higher scores on the ease of use construct. In multivariate analysis, only TAME-ChatGPT constructs explained the variance in attitude towards ChatGPT (80.8%) and its usage (76.9%).
Conclusions
The findings indicated that ChatGPT usage is commonplace among university students in the UAE. The determinants of use included the perceived usefulness, lower perceived risks, cognitive and behavioral factors, perceived ease of use, while the attitude was determined by lower perceived risks, lower anxiety, and higher scores for attitude to technology/social influence. These factors should be considered for understanding the motivators for successful adoption of generative AI including ChatGPT in higher education.
Identification of HDAC10 as a candidate oncogene in clear cell renal carcinoma that facilitates tumor proliferation and metastasis.
Authors: Yang Luojia , Wei Qin , Chen Xinran , Yang Yang , Huang Qingbo , Wang Baojun , Ma Xin 
Published: February 2024

Abstract
Background
Clear cell renal carcinoma (ccRCC) seriously threatens people’s health worldwide. Numerous studies have revealed that histone deacetylases (HDACs) affect the cell proliferation, apoptosis and cell differentiation. Nevertheless, the biological function of histone deacetylation modification related genes in the carcinogenesis, progression, and prognosis of ccRCC remains poorly understood.
Method
Bulk transcriptomic data and clinical information of ccRCC patients were obtained from the TCGA database and the Chinese PLA General Hospital. A total of 36 histone deacetylation genes were included in our study. Univariate cox regression analysis, least absolute shrinkage and selection operator (LASSO) regression, random forest (RF) analysis, and protein-protein interaction (PPI) network analysis were employed to identify key genes affecting the prognosis of ccRCC patients. The ‘oncoPredict’ algorithm was utilized for drug-sensitive analysis. GSEA and KEGG enrichment analysis was used to explore the potential biological function. The ssGSEA algorithm was used for tumor immune microenvironment analysis. The expression levels of HDAC10 were validated by RT-PCR and immunohistochemistry (IHC). EdU assay, CCK-8 assay, cell transwell migration and invasion assay and colony formation assay were performed to detect the proliferation and invasion ability of ccRCC cells. A nomogram incorporating HDAC10 and clinicopathological characteristics was established to predict the prognosis of ccRCC patients.
Result
Two machine learning algorithms and PPI analysis identified four histone deacetylation genes that have a significant association with the prognosis of ccRCC patients, with HDAC10 being the key gene among them. HDAC10 is highly expressed in ccRCC and its high expression is associated with poor prognosis. Pathway enrichment and the experiments of 5-ethynyl-2′-deoxyuridine (EdU) staining, CCK-8 assay, cell transwell migration and invasion assay and colony formation assay detected that HDAC10 may mediated the proliferation and the metastasis of ccRCC. HDAC10 may also be involved in reshaping the tumor microenvironment (TME) of ccRCC. A clinically reliable prognostic predictive model was established by incorporating HDAC10 and other clinicopathological characteristics ( https://nomogramhdac10.shinyapps.io/HDAC10_Nomogram/ ).
Conclusion
Our study found the increased expression of HDAC10 was closely associated with poor prognosis of ccRCC patients. HDAC10 may have a pro-tumorigenic effect on ccRCC and promote the proliferation and metastasis of ccRCC, which may provide new light on targeted therapy for ccRCC.
Benefits and Risks of Antiplatelet Therapy After Bypass Surgery for Moyamoya Disease: A Meta-Analysis
Authors: Si Junchen , Kang Xiaokui , Li Zhongchen , Hao Jiheng , Zhang Liyong 
Published: February 2024

Abstract

Background: Bypass surgery is a leading treatment strategy for moyamoya disease. Antiplatelet therapy (APT) has the potential to prevent thrombosis and possibly enhance bypass graft patency. However, the efficacy and safety of APT following bypass surgery remain debatable. This study aims to assess the clinical outcomes of APT after bypass surgery.
Methods: A systematic review was conducted to evaluate the impact and associated complications of APT after bypass surgery. Electronic databases, including PubMed, Embase, and the Cochrane Library, were searched from their inception to September 1, 2023. The primary outcome was bypass patency.
Results: This meta-analysis included five articles, encompassing 480 patients who underwent APT post-bypass surgery and 423 patients who did not receive APT. Statistical analysis revealed that APT significantly increased bypass vessel patency (Odds Ratio [OR] 2.58; 95% Confidence Interval [CI] 1.51-4.43; P=0.0006), decreased the likelihood of transient cerebral ischemic events (OR 0.55; 95% CI 0.32-0.95; P=0.03), and enhanced patient functional outcomes (OR 1.88; 95% CI 1.29-2.74; P=0.001). However, no substantial differences were observed in postoperative stroke risk (OR 0.89; 95% CI 0.49-1.63; P=0.72), seizures (OR 1.43; 95% CI 0.61-3.37; P=0.41), or cerebral hemorrhage (OR 0.69; 95% CI 0.28-1.71; P=0.42) between the two groups.
Conclusions: The current evidence indicates that APT following bypass surgery enhances bypass vessel patency, reduces the risk of transient cerebral ischemic events, and improves functional outcomes in patients. However, it does not decrease the incidence of postoperative stroke and does not elevate the risks of cerebral hemorrhage and seizures.
A Novel Approach for Tweet Similarity in a Context-Aware Fake News Detection Model
Authors: Bezerra Jose Fabio Ribeiro , Kozierkiewicz Adrianna , Pietranik Marcin 
Published: February 2024

Abstract
In this article, we address two problems: the detection of fake news using a multimodal, content, and context-driven approach and the evaluation of short-text messages (in our case, tweets) to compare how similar or different they are. For the first problem, we developed a framework for detecting fake news using a multilayered, multimodal approach consisting of a three-tiered model: the topic layer, the social layer, and the context layer, helping to establish a methodology for detecting fake news. Within the topic layer, one of its tasks is the calculation of how similar two messages are to each other. We developed an improved version of an existing model, adapted it to our framework, and included calculating certain words and their positions as features and a novel embedding method using Cosine Similarity and POS (Parts of Speech) tags. We used the dataset from STSBenchmark and the correlation value to measure the quality of our model and performed a 50-fold evaluation over the validation data. Ultimately, our model has a better correlation value (median 0.673528) than the benchmarked model. Our main contribution is the delivery of a reliable, formal, and adaptable framework for identifying fake news; we also present a means of comparing tweets by their content, utilizing FastText models, cosine similarity, and other measures, making our contribution practical and effective.
Efficacy of medicinal plants and their derived biomolecules against apicomplexan pathogen
Authors: Qulsum Umme , Azad Md Thoufic Anam , Kato Kentaro 
Published: February 2024

Abstract
Background: Many apicomplexan pathogens pose significant threats to humans and domestic animals, with the lack of effective drugs and drug resistance representing major challenges in disease management. To address this, the search for new and potent antimalarial drugs is crucial. Plant-based formulations offer a promising alternative for such drug development. Here, we evaluated the in vitro antiplasmodial activity of nine plant extracts, traditionally used to treat fever-like symptoms in Bangladesh.
Methods: We assessed the antimalarial activity of plant extracts by using the Plasmodium falciparum 3D7 growth inhibition assay, an invasion assay, and a cytotoxicity assay.
Results: Of the nine plants studied, ethanolic and methanolic leaf extracts of Ficus hispida, Streblus asper, and Boerhavia repens exhibited high antiplasmodial activity, with IC50 values of 9.31, 4.13, 9.63 μg/ml (ethanolic) and 15.58, 6.63, 7.58 μg/ml (methanolic), respectively, and minimal toxicity (cell viability >80%). Clerodendrum viscosum displayed antiplasmodial effects with IC50 values of 42.43 μg/ml (ethanolic) and 27.01 μg/ml (methanolic). Adhatoda vasica, Mussaenda corymbosa, and Amaranthus spinosus ethanolic extracts showed antimalarial effects with IC50 values of 59.59 μg/ml, 57.09 μg/ml, and 64.14 μg/ml, respectively. However, methanolic extracts of Adhatoda vasica and Amaranthus spinosus had IC50 values >100 μg/ml. The ethanolic and methanolic extracts of Adhatoda vasica, Amaranthus spinosus, Ficus hispida, Streblus asper, and Boerhavia repens significantly reduced parasitemia by inhibiting invasion into erythrocytes.
Conclusions: This study highlights the robust antimalarial activity and low cytotoxicity of leaf extracts of Ficus hispida, Streblus asper, and Boerhavia repens, indicating the presence of antimalarial compounds that warrant further investigation.
Impact of road corridors on soil properties and plant communities in high-elevation fragile ecosystems
Authors: Bao Wenjie , Zhang Wenfu , Dong Jinlong , Yang Xiaodong , xia shangwen , Chen Hui 
Published: February 2024

Abstract

Road construction constitutes a significant disruption to natural ecosystems. Globally, high-elevation regions are among the most fragile and sensitive ecosystems, while systematic information regarding the impact of road construction on soil properties and plant communities in these regions remains scarce. In this study, paired plots were established along the road route from Yunnan Province to Tibet Autonomous Region in Southwest China, with elevation ranging from 2,400 m to 4,900 m. Results revealed the restoration of soil properties post-disturbance had been a multifaceted and long-term progress. Specifically, disturbed plots exhibited a significant increase in soil pH, while soil moisture, TC, TN, TP, NH4-N, and AK suffered substantial loss. Moreover, the strong recovery ability of shrub and herbaceous species was observed in our study, while tree communities were difficult to revert to their original state. Furthermore, the influence of elevation on vegetation restoration also varied depending on plant life forms. In light of these findings, appropriate strategies were proposed to mitigate the negative impacts and promote the ecosystem recovery after road construction in these ecologically fragile regions.