bluuebunny/crossref_metadata_2025_split huggingface dataset:
Experiences in aligning WHO SMART guidelines to classification and terminology standards
Authors: Pretty Filippa , Tamrat Tigest , Ratanaprayul Natschja , Barreix Maria , Kostanjsek Nenad Friedrich Ivan , Gaffield Mary-Lyn , Thompson Jenny , Rhodes Bryn , Jakob Robert , Mehl Garrett Livingston , Tunçalp Özge 
Published: January 2024

ObjectivesDigital adaptation kits (DAKs) distill WHO guidelines for digital use by representing them as workflows, data dictionaries and decision support tables. This paper aims to highlight key lessons learnt in coding data elements of the antenatal care (ANC) and family planning DAKs to standardised classifications and terminologies (CATs).MethodsWe encoded data elements within the ANC and family planning DAKs to standardised CATs from the WHO CATs and other freely available CATs.ResultsThe coding process demonstrated approaches to refine the data dictionaries and enhance alignment between data elements and CATs.DiscussionApplying CATs to WHO clinical and public health guidelines can ensure that recommendations are operationalised in a digital system with appropriate consistency and clarity. This requires a multidisciplinary team and careful review to achieve conceptual equivalence between data elements and standardised terminologies.ConclusionThe systematic translation of guidelines into digital systems provides an opportunity for leveraging CATs; however, this approach needs further exploration into its implementation in country contexts and transition into machine-readable components.
Social vulnerability and initial COVID-19 community spread in the US South: a machine learning approach
Authors: Tatar Moosa , Faraji Mohammad Reza , Wilson Fernando A 
Published: January 2024

Background and objectivesMore than 93 million COVID-19 cases and more than 1 million COVID-19 deaths have been reported in the USA by August 2022. The disproportionate effect of the pandemic and its severe impact on vulnerable communities raised concerns. This research aimed to identify and rank Social Vulnerability Index (SVI) factors highly predictive of the spread of COVID-19 in the US South at the beginning of the pandemic.MethodsWe used Extreme Gradient Boosting (XGBoost) machine learning methodology and SVI data, and the number of COVID-19 cases across all counties in the US South to predict the number of positive cases within 30 days of a county’s first case.ResultsOur results showed that the percentage of mobile homes is the most important feature in predicting the increase in COVID-19. Also, population density per square mile, per capita income, percentage of housing in structures with 10+ units, percentage of people below poverty and percentage of people with no high school diploma are important predictors of COVID-19 community spread, respectively.ConclusionsSVI can help assess the vulnerability or resilience of communities to the spread of COVID-19 and can help identify communities at high risk of COVID-19 spread.
Electronic consent in clinical care: an international scoping review
Authors: Chimonas Susan , Lipitz-Snyderman Allison , Matsoukas Konstantina , Kuperman Gilad 
Published: January 2024

ObjectiveDigital technologies create opportunities for improvement of consenting processes in clinical care. Yet little is known about the prevalence, characteristics or outcomes of shifting from paper to electronic consenting, or e-consent, in clinical settings. Thus questions remain around e-consent’s impact on efficiency, data integrity, user experience, care access, equity and quality. Our objective was to scope all known findings on this critical topic.Materials and methodsThrough an international, systematic scoping review, we identified and assessed all published findings on clinical e-consent in the scholarly and grey literatures, including consents for telehealth encounters, procedures and health information exchanges. From each relevant publication, we abstracted data on study design, measures, findings and other study features.Main outcome measuresMetrics describing or evaluating clinical e-consent, including preferences for paper versus e-consenting; efficiency (eg, time, workload) and effectiveness (eg, data integrity, care quality). User characteristics were captured where available.ResultsA total of 25 articles published since 2005, most from North America or Europe, report on the deployment of e-consent in surgery, oncology and other clinical settings. Experimental designs and other study characteristics vary, but nearly all focus on procedural e-consents. Synthesis reveals relatively consistent findings around improved efficiency and data integrity with, and user preferences for, e-consent. Care access and quality issues are less frequently explored, with disparate findings.Discussion and conclusionThe literature is nascent and largely focused on issues that are immediate and straightforward to measure. As virtual care pathways expand, more research is urgently needed to ensure that care quality and access are advanced, not compromised, by e-consent.
Recent American College of Physicians Guidance Statement for Screening Average-risk, Asymptomatic Adults for Colorectal Cancer
Authors: Hawk Ernest T. , Martch Stephanie L. 
Published: January 2024

Abstract
The American College of Physicians (ACP) update of their standing guidance statement for colorectal-cancer screening in asymptomatic average-risk adults was recently published to assist clinicians with implementing evidence-based patient care. After assessing existing guideline literature, the ACP recommended five actions: consider not screening adults ages 45 to 49 years; stop screening adults older than 75 years; discuss benefits, harms, costs, availability, frequency, and patient values/preferences with patients prior to choosing a screening method; and when choosing, recommend biennial rather than annual use of a fecal immunochemical test or a guaiac fecal occult blood test and avoid recommending computed tomography colonography or stool DNA tests. While the ACP guidelines are rigorous, well-intended, and considerate of patients’ input, their greatest impact may result from highlighting the need for researchers to help frontline clinicians to describe the risk, costs, and benefits/harms of various colorectal-cancer screening strategies in an effective, yet time-efficient, manner given the all-too-brief annual patient encounters. In the United States, reimbursement is still dependent on U.S. Preventive Services Task Force recommendations which are somewhat more liberal in contrast to the ACP's approach which strongly favors randomized, controlled trial evidence to guide the delivery of prevention and screening services to asymptomatic average-risk patients.
Thrombomodulin Switches Signaling and Protease-Activated Receptor 1 Cleavage Specificity of Thrombin
Authors: Biswas Indranil , Giri Hemant , Panicker Sumith R. , Rezaie Alireza R. 
Published: January 2024

BACKGROUND:
Cleavage of the extracellular domain of PAR1 (protease-activated receptor 1) by thrombin at Arg41 and by APC (activated protein C) at Arg46 initiates paradoxical cytopathic and cytoprotective signaling in endothelial cells. In the latter case, the ligand-dependent coreceptor signaling by EPCR (endothelial protein C receptor) is required for the protective PAR1 signaling by APC. Here, we investigated the role of thrombomodulin in determining the specificity of PAR1 signaling by thrombin.

METHODS:

We prepared a PAR1 knockout (PAR1
−/−
) EA.hy926 endothelial cell line by CRISPR/Cas9 and transduced PAR1
−/−
cells with lentivirus vectors expressing PAR1 mutants in which either Arg41 or Arg46 was replaced with an Ala. Furthermore, human embryonic kidney 293 cells were transfected with wild-type or mutant PAR1 cleavage reporter constructs carrying N-terminal Nluc (NanoLuc luciferase) and C-terminal enhanced yellow fluorescent protein tags.

RESULTS:
Characterization of transfected cells in signaling and receptor cleavage assays revealed that, upon interaction with thrombomodulin, thrombin cleaves Arg46 to elicit cytoprotective effects by a β-arrestin-2 biased signaling mechanism. Analysis of functional data and cleavage rates indicated that thrombin-thrombomodulin cleaves Arg46>10-fold faster than APC. Upon interaction with thrombin, the cytoplasmic domain of thrombomodulin recruited both β-arrestin-1 and -2 to the plasma membrane. Thus, the thrombin cleavage of Arg41 was also cytoprotective in thrombomodulin-expressing cells by β-arrestin-1-biased signaling. APC in the absence of EPCR cleaved Arg41 to initiate disruptive signaling responses like thrombin.

CONCLUSIONS:
These results suggest that coreceptor signaling by thrombomodulin and EPCR determines the PAR1 cleavage and signaling specificity of thrombin and APC, respectively.
Atypical hemispheric re-organization of the reading network in high-functioning adults with dyslexia: Evidence from representational similarity analysis
Authors: Cavalli Eddy , Chanoine Valérie , Tan Yufei , Anton Jean-Luc , Giordano Bruno L. , Pegado Felipe , Ziegler Johannes C. 
Published: January 2024

Abstract
It has been argued that university students with dyslexia compensate for their reading deficits by a neural re-organization of the typical reading network, where the lexical representations of words are (re-)structured according to semantic rather than orthographic information. To investigate the re-organization of neural word representations more directly, we used multivariate representational similarity analyses (RSA) to find out which brain regions of the reading network respond to orthographic and semantic similarity between 544 pairs of words and whether there were any differences between typical and dyslexic readers. In accordance with the re-organization hypothesis, we predicted greater similarity (i.e., correlation of neural dissimilarity matrices) in adult dyslexic than in typical readers in regions associated with semantic processing and weaker similarity in regions associated with orthographic processing. Our results did not confirm these predictions. First, we found sensitivity to semantic similarity in all three subparts of the fusiform gyrus (FG1, FG2, and FG3) bilaterally. Adults with dyslexia showed less (rather than more) sensitivity to semantic similarity in the posterior subpart of fusiform gyrus (FG1) in the left hemisphere. Second, in typical readers, sensitivity to orthographic information was not only found in the left fusiform gyrus (FG1, FG2, and FG3) but also in left inferior frontal gyrus (IFG). Adults with dyslexia, in contrast, did not show sensitivity to orthographic information in left IFG. However, they showed increased sensitivity to orthographic information in the right hemisphere FG1. Together, the results show abnormal orthographic processing in left IFG and right FG1 and reduced semantic information in left FG1. While we found evidence for compensatory re-organization in adult dyslexia, the present results do not support the hypothesis according to which adults with dyslexia rely more heavily on semantic information. Instead, they revealed atypical hemispheric organization of the reading network that is not restricted to the typical left language hemisphere.
The Origins of the Peloponnesian War, the Origins of the Peloponnesian War, and Theories of International Relations
Authors: Low Polly 
Published: January 2024

Abstract
This article investigates the theoretical assumptions and implications of de Ste. Croix’s approach to interstate politics in The Origins of the Peloponnesian War. It suggests that two approaches can be identified in the work: one which sees a fundamental connection between political systems within a state and that state’s conduct of interstate politics, and another, closer to conventional ‘Realist’ theories, which sees a clear dividing line between domestic and interstate politics, and in which interstate relations need to be understood according to a distinct analytical framework. Although this tension was probably not a particular concern to de Ste. Croix himself, it does have a bearing on ongoing debates in International Theory; the final part of the article briefly explores the possibility that the concept of ‘compulsion’, important to both Thucydides’ and de Ste. Croix’s understanding of the causes of the Peloponnesian War, might provide a way of reconciling these two approaches.
Between ‘The Character of the Athenian Empire’ and The Origins of the Peloponnesian War (and beyond)
Authors: Canevaro Mirko , Lewis David 
Published: January 2024

Abstract
This article discusses the fortune of Geoffrey de Ste. Croix’s famous article ‘The Character of the Athenian Empire’, and reassesses its basic thesis that the Athenian Empire was popular among the lower classes of the allied cities in the light of recent developments in the field. After surveying the article’s immediate and more recent reception, and discussing its relation with The Origins of the Peloponnesian War and The Class Struggle in the Ancient Greek World, it isolates four key new trends in Greek history that, while going against some of Ste. Croix’s basic convictions, end up reinforcing his overall case. These are: a renewed attention to the mass and elite dichotomy, with recent work interpreting Greek oligarchy as a fundamentally reactive and anti-demotic regime; the recognition of the continued relevance of Persian meddling in the later fifth-century; a sea-change in Attic epigraphy which has led to the post-dating of several ‘imperial’ decrees; the new recognition of the dynamism of the Greek economy, and of the economic function of the Athenian Empire itself. Finally, the article addresses the paradigm of class struggle and stresses how democracy and economic dynamism, to which the Athenian Empire contributed, fostered the growth of slave markets and worsened the exploitation of ‘marginal’ regions as slave suppliers.
Improving the Science for Wildland Fire Prediction at S2S Scales
Authors: Turner D. D. , Ott L. , Steblein P. F. , Stieglitz M. , Tweedy O. , Furman J. , James C. S. 
Published: January 2024

Abstract
The size, duration, impact, and cost of wildland fire is increasing over the last several decades. A recent Interagency Council for Advancing Meteorological Services (ICAMS)-sponsored workshop focused on the scientific questions and challenges associated with subseasonal-to-seasonal wildfire outlooks. Opinions from this workshop, including recommended cross-agency motivation and activities, are provided.
Investigation of the effects of cellulose nanofiber on the properties of poly(vinyl alcohol) crosslinked by 2,5-furandicarboxylic acid
Authors: Pham Thi Ni , Ho Le Hanh Trang , Vu Trung Nam , Tran Hoang An , Nguyen Ngoc Mai , Nguyen Thu Ha , Le Quang Dien , Tran Thi Thuy 
Published: January 2024

Bio-based and biodegradable materials have received special interests in recent years as a replacement for petroleum-based plastics. Poly(vinyl alcohol) (PVA), cellulose nanofiber (CNF), and 2,5-furandicarboxylic acid (FDCA) are typical examples among these environmentally friendly molecules. In this study, we investigated the synergistic effects of CNF reinforcement and crosslinking with FDCA on the properties of PVA. The composite films were prepared via a straightforward mechanical-dispersion method, wherein CNF was incorporated into a PVA solution and subsequently crosslinked with FDCA. Comprehensive characterizations, including Attenuated Total Reflection-Fourier Transform Infrared Spectroscopy (ATR-IR), X-ray diffraction (XRD), Thermal Gravimetric Analysis/Differential Thermal Gravimetric Analysis (TGA/DTGA), Differential Scanning Calorimetry (DSC), tensile testing, and morphological studies, were performed to assess the impact of these modifications. Our findings revealed significant enhancements in the mechanical and thermal properties of the composites. Notably, the tensile strength of the PVA-c-FDCA/CNF composite with 2% CNF reached 37.08 MPa, representing a twofold increase compared to both crosslinked PVA (16.84 MPa) and unmodified PVA (14.57 MPa). TGA/DTGA analysis demonstrated improved thermal stability, with the degradation temperature reaching 371°C, compared to the 298°C observed for PVA. DSC and XRD results indicated a reduction in PVA crystallinity after crosslinking and blending with CNF. Scanning electron microscopy (SEM) images showed good compatibility between PVA and CNF. This study underscores the potential of CNF reinforcement and FDCA crosslinking as a viable strategy to enhance the mechanical properties of PVA-based materials.
Investigating temperature variability on antioxidative behavior of synthesized cerium oxide nanoparticle for potential biomedical application
Authors: Pandey Shivam , Kumari Sneha , Manohar Aeshala Leela , Singh Sushant 
Published: January 2024

Cerium oxide nanoparticles (CNP) have garnered significant attention due to their versatile redox properties and wound-healing applications. The antioxidative nature of CNP is due to its ability to be oxidized and reduced, followed by the capture or release of oxygen which is used for scavenging reactive oxygen species (ROS). Herein, CNP is produced through a wet chemistry approach and its tunable redox property is tested across a range of temperatures. The synthesized CNP was observed to reveal the signature peak at 245 nm indicating a high Ce+3/Ce+4 ratio. Towards evaluating the redox antioxidative behavior, CNPs were subjected to a comprehensive analysis for superoxide dismutase mimetic analysis with riboflavin-mediated nitroblue tetrazolium scavenging assay. The results demonstrated that the redox activity of cerium oxide nanoparticles was strongly influenced by the different temperature ranges. Superoxide dismutase mimetic activity was observed to be reduced with a decrease in temperature as we moved from 4°C (80% activity) to −80°C (47% activity) at 1 mM conc of CNP. Similarly, the SOD mimetic activity increased with an increase in temperature from 40°C (72% activity) to 70°C (94% activity). Further, CNP was found to inhibit E. coli (gram+ve) and Enterobacter (gram−ve) beyond 70% simultaneously at 1 mM conc, indicating its potential application as a remarkable antimicrobial agent. CNP also inhibited the alpha-amylase activity up to the 60% at 1 mM conc suggesting its potential application in antidiabetic wound healing therapy. Overall, the CNP finds its application in mitigating the oxidative stress-related disorder exhibited by its high antioxidative, antimicrobial, and antidiabetic behavior.
Effects of systemic oxytocin administration on ultraviolet B-induced nociceptive hypersensitivity and tactile hyposensitivity in mice
Authors: Boada M Danilo , Gutierrez Silvia , Eisenach James C 
Published: January 2024

Ultraviolet B (UVB) radiation induces cutaneous inflammation, leading to thermal and mechanical hypersensitivity. Here, we examine the mechanical properties and profile of tactile and nociceptive peripheral afferents functionally disrupted by this injury and the role of oxytocin (OXT) as a modulator of this disruption. We recorded intracellularly from L4 afferents innervating the irradiated area (5.1 J/cm2) in 4-6 old week male mice (C57BL/6J) after administering OXT intraperitoneally, 6 mg/Kg. The distribution of recorded neurons was shifted by UVB radiation to a pattern observed after acute and chronic injuries and reduced mechanical thresholds of A and C- high threshold mechanoreceptors while reducing tactile sensitivity. UVB radiation did not change somatic membrane electrical properties or fiber conduction velocity. OXT systemic administration rapidly reversed these peripheral changes toward normal in both low and high-threshold mechanoreceptors and shifted recorded neuron distribution toward normal. OXT and V1aR receptors were present on the terminals of myelinated and unmyelinated afferents innervating the skin. We conclude that UVB radiation, similar to local tissue surgical injury, cancer metastasis, and peripheral nerve injury, alters the distribution of low and high threshold mechanoreceptors afferents and sensitizes nociceptors while desensitizing tactile units. Acute systemic OXT administration partially returns all of those effects to normal.
Screening with urine Histoplasma antigen test in asymptomatic patients starting TNF-alpha inhibitor therapy: a cohort study
Authors: Cipolat Murillo M. , Rodrigues Débora R. R. , Silveira Letícia G. , Silveira Inês G. , Nothaft Mahara S. V. , Brenol Claiton V. , da Silva Larissa R. , Pasqualotto Alessandro C. , Falci Diego R. 
Published: January 2024

Background: Histoplasmosis is the second most frequent granulomatous disease in patients treated with tumor necrosis factor (TNF)-α inhibitors, second only to tuberculosis. However, there is limited information about pre-therapy screening procedures and the need for preventive treatments for patients who will start immunobiologicals. Methods: This is a cohort study that evaluated the prevalence of histoplasmosis in asymptomatic HIV-negative patients before initiation of TNF-α inhibitors by testing for Histoplasma antigen in urine samples. The patients included completed a 180-day follow-up after the initiation of the biologics to assess the onset of symptoms suggestive of histoplasmosis. Results: From January 2021 to December 2022, 54 patients who were prescribed a TNF-α inhibitor agent for treating autoimmune diseases in centers in southern Brazil were included. In the screening before therapy, the prevalence of a positive urinary Histoplasma antigen test was 14.8%. None of the 54 patients developed histoplasmosis after 6 months of immunobiological therapy, including the eight patients who tested positive. Conclusion: The prevalence of Histoplasma capsulatum infection in chronic patients may be higher than expected, but the impact of latent infection in asymptomatic patients is still uncertain, including those starting treatment with immunobiological drugs such as TNF-α inhibitors. Our study did not identify risk factors for the diagnosis of disseminated histoplasmosis in this group, including a positive result in an antigen test performed before immunobiological therapy. To date, there is no evidence to recommend routine antigen-based screening or preventive therapy for histoplasmosis before initiating a TNF-α inhibitor.