bluuebunny/crossref_metadata_2025_split huggingface dataset:
Employment of a high throughput functional assay to define the critical factors that influence vaccine induced cross-variant neutralizing antibodies for SARS-CoV-2
Authors: Gu Yue , Shunmuganathan Bhuvaneshwari , Qian Xinlei , Gupta Rashi , Tan Rebecca S. W. , Kozma Mary , Purushotorman Kiren , Murali Tanusya M. , Tan Nikki Y. J. , Preiser Peter R. , Lescar Julien , Nasir Haziq , Somani Jyoti , Tambyah Paul A. ,   SCOPE Cohort Study Group, Fong Siew-Wai , Amrun Siti Naqiah , Goh Yun-Shan , Tay Matthew Zi-Rui , Rouers Angeline , Chang Zi Wei , Yeo Nicholas Kim-Wah , Chan Yi-Hao , Hor Pei Xian , Loh Chiew Yee , Yang Yuling , Ruesta Anthony Torres , Neo Vanessa , Chen Wendy Yehui , Goh Estelle Yi-Wei , Ong Alice Soh-Meoy , Chua Adeline Chiew Yen , Nguee Samantha , Tang Yong Jie , Tang Weiyi , Wong Joel Xu En , Smith Kenneth G. C. , Renia Laurent , Ng Lisa F. P. , Lye David C. , Young Barnaby E. , MacAry Paul A. 
Published: December 2023

AbstractThe scale and duration of neutralizing antibody responses targeting SARS-CoV-2 viral variants represents a critically important serological parameter that predicts protective immunity for COVID-19. In this study, we describe the development and employment of a new functional assay that measures neutralizing antibodies for SARS-CoV-2 and present longitudinal data illustrating the impact of age, sex and comorbidities on the kinetics and strength of vaccine-induced antibody responses for key variants in an Asian volunteer cohort. We also present an accurate quantitation of serological responses for SARS-CoV-2 that exploits a unique set of in-house, recombinant human monoclonal antibodies targeting the viral Spike and nucleocapsid proteins and demonstrate a reduction in neutralizing antibody titres across all groups 6 months post-vaccination. We also observe a marked reduction in the serological binding activity and neutralizing responses targeting recently newly emerged Omicron variants including XBB 1.5 and highlight a significant increase in cross-protective neutralizing antibody responses following a third dose (boost) of vaccine. These data illustrate how key virological factors such as immune escape mutations combined with host demographic factors such as age and sex of the vaccinated individual influence the strength and duration of cross-protective serological immunity for COVID-19.
Multiple host colonization and differential expansion of multidrug-resistant ST25-Acinetobacter baumannii clades
Authors: Lupo Agnese , Valot Benoît , Saras Estelle , Drapeau Antoine , Robert Marine , Bour Maxime , Haenni Marisa , Plésiat Patrick , Madec Jean-Yves , Potron Anaïs 
Published: December 2023

AbstractThe Acinetobacter baumannii clonal lineage ST25 has been identified in humans and animals and found associated with outbreaks globally. To highlight possible similarities among ST25 A. baumannii of animal and human origins and to gather clues on the dissemination and evolution of the ST25 lineage, we conducted a phylogenetic analysis on n = 106 human and n = 35 animal A. baumannii ST25 genomes, including 44 sequenced for this study. Resistance genes and their genetic background were analyzed, as well. ST25 genomes are clustered into four clades: two are widespread in South America, while the other two are largely distributed in Europe, Asia and America. One particular clade was found to include the most recent strains and the highest number of acquired antibiotic resistance genes. OXA-23-type carbapenemase was the most common. Other resistance genes such as blaNDM-1, blaPER-7, and armA were found embedded in complex chromosomal regions present in human isolates. Genomic similarity among multidrug resistant ST25 isolates of either animal or human origin was revealed, suggesting cross-contaminations between the two sectors. Tracking the clonal complex ST25 between humans and animals should provide new insights into the mode of dissemination of these bacteria, and should help defining strategies for preserving global health.
Attacking cryptosystems by means of virus machines
Authors: Pérez-Jiménez Mario J. , Ramírez-de-Arellano Antonio , Orellana-Martín David 
Published: December 2023

AbstractThe security that resides in thepublic-key cryptosystemsrelies on the presumed computational hardness of mathematical problems behind the systems themselves (e.g. thesemiprime factorization problemin theRSAcryptosystem), that is because there is not known any polynomial time (classical) algorithm to solve them. The paper focuses on the computing paradigm ofvirus machineswithin the area of Unconventional Computing and Natural Computing. Virus machines, which incorporate concepts of virology and computer science, are considered as number computing devices with the environment. The paper designs a virus machine that solves a generalization of the semiprime factorization problem and verifies it formally.
Prediction of transportation index for urban patterns in small and medium-sized Indian cities using hybrid RidgeGAN model
Authors: Thottolil Rahisha , Kumar Uttam , Chakraborty Tanujit 
Published: December 2023

AbstractThe rapid urbanization trend in most developing countries including India is creating a plethora of civic concerns such as loss of green space, degradation of environmental health, scarcity of clean water, rise in air pollution, and exacerbated traffic congestion resulting in significant delays in vehicular transportation. To address the intricate nature of transportation issues, many researchers and planners have analyzed the complexities of urban and regional road systems using transportation models by employing transportation indices such as road length, network density, accessibility, and connectivity metrics. This study addresses the complexities of predicting road network density for small and medium-sized Indian cities that come under the Integrated Development of Small and Medium Towns (IDSMT) project at a national level. A hybrid framework based on Kernel Ridge Regression (KRR) and the CityGAN model is introduced to predict network density using spatial indicators of human settlements. The major goal of this study is to generate hyper-realistic urban patterns of small and medium-sized Indian cities using an unsupervised CityGAN model and to study the causal relationship between human settlement indices (HSIs) and transportation index (network density) using supervised KRR for the real cities. The synthetic urban universes mimic Indian urban patterns and evaluating their landscape structures through the settlement indices can aid in comprehending urban landscape, thereby enhancing sustainable urban planning. We analyzed 503 real cities to find the actual relationship between the urban settlements and their road density. The nonlinear KRR model may help urban planners in deriving the network density for GAN-generated futuristic urban patterns through the settlement indicators. The proposed hybrid process, termed as RidgeGAN model, can gauge the sustainability of urban sprawl tied to infrastructure and transportation systems in sprawling cities. Analysis results clearly demonstrate the utility of RidgeGAN in predicting network density for different kinds of human settlements, particularly for small and medium Indian cities. By predicting future urban patterns, this study can help in the creation of more livable and sustainable areas, particularly by improving transportation infrastructure in developing cities.
Dissolving sodium hydrosulfide in drinking water is not a good source of hydrogen sulfide for animal studies
Authors: Ghasemi Asghar , Jeddi Sajad , Yousefzadeh Nasibeh , Kashfi Khosrow , Norouzirad Reza 
Published: December 2023

AbstractHydrogen sulfide (H2S) has many physiological and pathological roles in the human body. Sodium hydrosulfide (NaHS) is widely used as a pharmacological tool for assessing H2S effects in biological experiments. Although H2S loss from NaHS solution is a matter of minutes, some animal studies use NaHS in solution as an H2S-donating compound in drinking water. This study addresses whether 30 μM NaHS in drinking water prepared in rat/mouse water bottles remains stable for at least 12–24 h, as presumed by some authors. NaHS solutions (30 μM) were prepared in drinking water and immediately transferred to rat/mice water bottles. Samples were obtained from the tip of water bottles and from inside of the bottles at 0, 1, 2, 3, 4, 5, 6, 12, and 24 h for sulfide measurement using the methylene blue method. Furthermore, NaHS (30 μM) was administered to male and female rats for two weeks, and serum sulfide concentrations were measured every other day in the first week and at the end of the second week. NaHS solution was unstable in the samples obtained from the tip of water bottles; it declined by 72% and 75% after 12 and 24 h, respectively. In the samples obtained from the inside of the water bottles, the decline in the NaHS was not significant until 2 h; however, it decreased by 47% and 72% after 12 and 24 h, respectively. NaHS administration did not affect serum sulfide levels in male and female rats. In conclusion, NaHS solution prepared in drinking water can not be used for H2S donation as the solution is unstable. This route of administration exposes animals to variable and lower-than-expected amounts of NaHS.
Promoter swapping of truncated PDGFRB drives Ph-like acute lymphoblastic leukemia
Authors: Miyazaki Bunpei , Ueno Toshihide , Sugiyama Masanaka , Kojima Shinya , Arakawa Ayumu , Tao Kayoko , Tanimura Kazuki , Shiraishi Kouya , Yagishita Shigehiro , Kohsaka Shinji , Kato Mamoru , Kiyokawa Nobutaka , Goto Yasushi , Yatabe Yasushi , Hamada Akinobu , Mano Hiroyuki , Ogawa Chitose , Tanaka Yosuke 
Published: December 2023

AbstractPhiladelphia chromosome (Ph)-like acute lymphoblastic leukemia (ALL) is a subset of ALL that demonstrated a high treatment failure rate. One of the hallmarks of Ph-like ALL is PDGFRB gene fusion, with fusion partner proteins often harboring dimerization domains and enhancing the kinase activity of PDGFRB. We determined a novel oncogenic PDGFRB fusion gene, NRIP1::PDGFRB, from a pediatric patient with ALL, encoding a protein with the carboxy-terminal kinase domain of PDGFRB, without the partner peptide. We confirmed the oncogenic potential of NRIP1::PDGFRB in vitro and the efficacy of all ABL1-specific inhibitor generations, including imatinib, dasatinib, nilotinib, and ponatinib, in suppressing this potential. PDGFRB activation mechanism may include juxtamembrane domain truncation in the predicted peptide. In conclusion, we determined a novel fusion gene pattern in Ph-like ALL.
Movement examination of the lumbar spine using a developed wearable motion sensor
Authors: Abbasi‐Kesbi Reza , Fathi Mohammad , Sajadi Seyed Zaniyar 
Published: December 2023

AbstractA system for monitoring spinal movements based on wearable motion sensors is proposed here. For this purpose, a hardware system is first developed that measures data of linear acceleration, angular velocity, and the magnetic field of the spine. Then, the obtained data from these sensors are combined in a proposed complementary filter, and their angular variations are estimated. The obtained results of angular variation of this system in comparison with an accurate reference illustrate that the root mean squared error is less than 1.61 degrees for three angles of , and for this system that proves this system can accurately estimate the angular variation of the spine. Then, the system is mounted on the lumbar spine of several volunteers, and the obtained angles from the patients' spine are compared with some healthy volunteers' spine, and the performance of their spine improves over time. The results show that this system can be very effective for patients who suffer from back problems and help in their recovery process a lot.
A high gain circularly polarised magnetoelectric dipole antenna array with metallic radiating structures for millimetre‐wave applications
Authors: Ye Zihang , Tian Jin , Xiao Jun , Ding Tongyu , Han Chongzhi , Ye Qiubo 
Published: December 2023

AbstractAn antenna array design method of trade‐off between high gain and low profile is proposed. A high‐gain circularly polarised (CP) substrate integrated waveguide (SIW)‐fed magnetoelectric dipole (ME‐dipole) antenna array with metallic radiating structures is presented for millimetre‐wave (MMW) applications. The CP antenna element comprises a set of horizontally and vertically metal plates and a metallic cavity that is excited by an X‐shaped coupling slot etched on the broader side of SIW. The metallic cavity is designed to improve the gain and axial ratio (AR) performances. Utilising this antenna element, a proof‐of‐concept is established through the design of a 2 × 2 subarray and a 4 × 4 array. The fabricated 4 × 4 CP antenna array has a measured impedance bandwidth of 6.1% (36.4–38.7 GHz), with |S11| ≤ −10dB. The measured 3dB AR bandwidth is 5.4% (36.0–38.0 GHz). The measured maximum gain achieved is 19.1 dBic. The height of the proposed array is 0.74λ0 which is larger than the heights of typical SIW‐based microstrip arrays (0.1–0.4λ0) and lower than the heights of metallic arrays (larger than 2λ0).
Quasi‐Z‐source inverter with switched‐coupled‐capacitors
Authors: Babaei Mohammad Hosein , Taheri Asghar , Abbasi Bolaghi Jamal , Gholami Masoumeh 
Published: December 2023

AbstractThis paper presents an improved switched‐inductor quasi‐Z‐source inverter with a higher boost factor than similar inverters, which integrates a switched‐capacitor and a three‐winding switched‐coupled inductor into a conventional quasi Z‐source inverter (q‐ZSI). The proposed inverter is called a switched‐capacitor trans quasi Z‐source inverter (SCT‐q‐ZSI). In this topology, the input current is continuous, and a high voltage gain is reachable with lowduty cycles (D). In this structure, capacitors are used instead of the side diodes of the switched‐inductor quasi Z‐source inverter. The proposed converter has a low inrush current at the startup which might damage the converter components. The performance of the proposed inverter is investigated at different operating modes and the voltage and current equations of all elements are calculated. The analysis, derivation of boost factor, capacitor voltages, and components, of the proposed inverter, are carried out and are compared with similar inverters. Finally, analytical, simulation, and experimental results are also presented to validate its advantages.
Experimental evaluation of the backstepping‐based input resistance controller in step‐up DC–DC converter for maximum power point tracking of the thermoelectric generators
Authors: Mogadam Sarah Kowsari , Salimi Mahdi , Bathaee Seyyed Mohammad Taghi , Mirabasi Davar 
Published: December 2023

AbstractIn this paper, a novel non‐linear model‐based approach is presented for maximum power point (MPP) tracking of thermoelectric generators (TEGs) using the backstepping controller. Considering the output voltage range of the thermoelectric devices, a step‐up DC–DC converter is employed as an interface between the load and input power source. According to the maximum power transfer theorem, if the equivalent input resistance of the converter (Rin) is equal to the internal resistance of the input source (RTEG), the TEG operation at the MPP will be achieved. Hence, defining the RTEG as a reference value and Rin as a feedback variable for a closed‐loop controller, the backstepping non‐linear controller is developed for input resistance control of the boost DC–DC converter. Owing to the non‐linear nature of the error variable in the input resistance control of the converters, conventional linear controllers cannot guarantee the system's closed‐loop stability within an extensive operational range. However, despite changes in generator's open‐circuit voltage (VOC) and RTEG, the designed closed‐loop controller can successfully stabilize the thermoelectric converter in different operational conditions. Considering the Lyapunov theorem and the Barbalat lemma, the asymptotic stability of the backstepping controller is proved. During the steady‐state operation, the actual values of the VOC and RTEG are updated periodically by the measurement of the converter input voltage/current values. To verify the functionality of the designed control method, PC‐based simulations are carried out in MATLAB/Simulink software. Moreover, by using TMS320F28335 digital signal processor from Texas Instruments and a simple thermoelectric simulator, the experimental response of the proposed controller is evaluated in dynamic and steady‐state conditions. The developed closed‐loop system can track the MPP of a TEG with zero steady‐state error, regardless of uncertain parameter variations.
Small‐signal impedance modelling and stability analysis of doubly fed induction generator‐based wind turbines during asymmetrical weak grid condition
Authors: Xu Hailiang , Li Zhi , Wu Han , Yan Qingzeng , Xu Lie 
Published: December 2023

AbstractDoubly fed induction generator (DFIG)‐based wind turbines (WTs) that connected into weak power grid may lose their stability. However, the stability issue becomes more complex and has not been well addressed during the asymmetric grid scenario, especially when the negative sequence current response is required, according to the latest grid codes. To settle such an issue, a small‐signal impedance model of the DFIG‐based WT with negative‐sequence current control is established in this paper. Based on the proposed model, the interaction mechanism between the DFIG and the imbalanced grid is analysed. The influence of the main physical and control parameters on the system stability is then assessed in detail. It is found that improper design of the notch filters in the control loop may arouse insufficient decoupling between the positive and negative components, which can further deteriorate the system stability and robustness. To cope with the problem, the setting rule of the quality factor of the second‐order notch filter, considering its dynamic and static characteristics, is derived. Simulations and experiments are finally conducted to validate the correctness of the theoretical analysis.
Recognition of objects in orbit and their intentions with space‐borne sub‐THz Inverse Synthetic Aperture Radar
Authors: Cherniakov Mikhail , Hoare Edward G. , Gashinova Marina , Marchetti Emidio , Stove Andrew G. 
Published: December 2023

AbstractAn important aspect of Space Situational Awareness is to estimate the intent of objects in space. This paper discusses how discriminating features can be obtained from Inverse Synthetic Aperture Radar images of such objects and how these discriminators can be used to recognise the objects or to estimate their intent. If the object is, for example, a satellite of a known type, the scheme proposed is able to recognise it. The ability of the scheme to detect damage to the object is also discussed. The focus is on imagery obtained in the sub‐terahertz band (typically 300 GHz) because of the greater imaging capability given by the diffuse scattering which is observed at these frequencies. The paper also discusses the importance of being able to use images obtained by electromagnetic simulation to be able to train the subsystem which recognises features of the objects and describes a practical scheme for creating these simulations for large objects at these very short wavelengths.
Robust factor graph optimisation method for shipborne GNSS/INS integrated navigation system
Authors: Hu Yuan , Li Haozheng , Liu Wei 
Published: December 2023

AbstractRobust Global Navigation Satellite System (GNSS) factors are introduced into a factor graph optimisation based integrated navigation system to address the challenge of occluded GNSS signals during ship navigation, which leads to increased errors in positioning results. To enhance the robustness of the GNSS tracking loop, a vector tracking method is applied to receiver tracking loop. Then, the Mahalanobis distance was employed to assess the pseudorange residual and identify and reject signals that exhibit anomalies. Specifically, the pseudorange residual is computed as the difference between the predicted pseudorange of the GNSS receiver and the measured pseudorange. Using the historical information in the window, robust GNSS factors were constructed for use in the factor graph. The robust factor graph optimisation method for a shipborne GNSS/Inertial Navigation System integrated navigation system was implemented by constructing robust GNSS factors and Inertial Measurement Unit factors. The experimental results confirm that the positioning accuracy of the proposed method is superior to those of the factor graph optimization and extended Kalman filter.
Von Cupro culta bis Eisenhammerschlag
Authors: Johann Ruth 
Published: December 2023

SummaryIn der Anthroposophischen Medizin spielen Metalle und insbesondere ihre pharmazeutische Aufbereitung eine wesentliche therapeutische Rolle, hier jeweils vorgestellt am Beispiel von Silber, Quecksilber, Kupfer, Gold, Eisen, Zinn und Blei. Zur Herstellung eines elementaren Metallspiegels wird das Metall durch Wärmezufuhr über den flüssigen und gasförmigen Aggregatzustand wieder in seinen festen Zustand überführt, durchläuft somit einen Verjüngungsprozess und erhält eine stärkere Dynamik. Während Metalle zur Vegetabilisierung Heilpflanzen als „Dünger“ zugesetzt werden, verbinden sich in Metallsalzen ihre therapeutischen Kräfte mit der Wirkung ihres jeweiligen Anions.
Zwischen Planet und Mensch
Authors: Löwensprung Natalie Rosenhauer-von 
Published: December 2023

SummaryAus Sicht der Anthroposophischen Medizin modulieren Metallkräfte über die Bewusstseinsebene der Ich-Organisation die Seelenorganisation, vermitteln zwischen Planet und Mensch und wirken auf alle Wesensglieder. Während das Saturnelement Blei zum Beispiel Strukturierung und Begrenzung und das Mondelement Silber Reflexion, Aufbau und Regeneration vermittelt, steht Zinn (Jupiter) für plastische Formbildung und Eisen (Mars) für Lebensenergie und Dynamik. Bei zu schwachen, dem jeweiligen Metall zugeordneten Prozessen wählt man meist niedrigere Potenzen (vorwiegend D3–10), während bei übersteigerten Prozessen überwiegend Verdünnungen im Bereich von D12–30 zur Anwendung kommen.
Update Mammakarzinom 2023 Teil 3 – Expertenmeinungen zu Brustkrebs in frühen Krankheitsstadien
Authors: Kolberg Hans-Christian , Hartkopf Andreas D. , Fehm Tanja N. , Welslau Manfred , Müller Volkmar , Schütz Florian , Fasching Peter A. , Janni Wolfgang , Witzel Isabell , Thomssen Christoph , Beierlein Milena , Belleville Erik , Untch Michael , Thill Marc , Tesch Hans , Ditsch Nina , Lux Michael P. , Aktas Bahriye , Banys-Paluchowski Maggie , Kolberg-Liedtke Cornelia , Wöckel Achim , Harbeck Nadia , Stickeler Elmar , Bartsch Rupert , Schneeweiss Andreas , Ettl Johannes , Krug David , Taran Florin-Andrei , Lüftner Diana , Würstlein Rachel 
Published: December 2023

ZusammenfassungIn einem 2-jährigen Rhythmus fand in St. Gallen in früheren Jahren und nun in Wien die „St. Gallen (SG) International Breast Cancer Conference“ statt. Dieses Jahr (2023) wurde diese Konferenz, die sich mit der Behandlung von Patientinnen in Frühstadien des Mammakarzinoms beschäftigt, zum 18. Mal durchgeführt. Am Ende dieser 4-tägigen Veranstaltung wird eine Panel-Abstimmung abgehalten, bei der ein Expertengremium über aktuelle kontroverse Themen bei der Behandlung von Brustkrebspatientinnen in Frühstadien abstimmt. Hierbei werden die Fragen meistens so formuliert, dass klinisch realistische Fälle – oft in verschiedenen Modifikationen – vorgestellt werden. Diese Übersichtsarbeit berichtet von den Abstimmungsergebnissen und fasst die mit den jeweiligen Fragen verbundene Datenlage zusammen.