bluuebunny/crossref_metadata_2025_split huggingface dataset:
Long‐term Survival of Transmural Advanced Gastric Carcinoma following Curative Resection: Multivariate Analysis of Prognostic Factors
Authors: Dhar Dipok Kumar , Kubota Hirofumi , Tachibana Mitsuo , Kotoh Tsukasa , Tabara Hideki , Watanabe Reiko , Kohno Hitoshi , Nagasue Naofumi 
Published: August 2002

Abstract.Patients with transmural (T2N0–T3N2) advanced gastric carcinoma comprise the largest group with uncertain outcome. These patients must be stratified according to the prognostic variables so the high risk group can be precisely identified. A total of 152 patients with transmural advanced gastric carcinomas were uniformly treated with a curative intent between 1979 and 1989 with at least a 7‐year follow‐up. Results and prognostic factors of long‐term survival were analyzed by univariate and multivariate analyses. Seventy‐five (49%) patients with advanced gastric carcinoma survived more than 7 years, which indicates the curative nature of surgery for gastric carcinoma. Seventeen variables were evaluated by univariate analysis. In the multivariate analysis, patient's age [> 70 years, relative risk (RR) 2.4)], intraoperative blood loss (> 500 ml, RR 1.7), blood vessel invasion (RR 2.3), ratio of invaded dissected lymph nodes (> 0.2, RR 3.0), and tumors penetrating the serosa (RR 3.9) were the independent prognostic variables. The results of this study indicate that extensive lymphadenectomy and minimal intraoperative blood loss might be helpful for improving patient survival following a curative resection. Patients with vessel invasion, serosal involvement, and those > 70 years of age should be considered at high risk and require appropriate adjuvant therapy to prolong survival.
Sex change and spatial distribution pattern in an intertidal holothurian Polycheira rufescens in the reproductive season
Authors: Arakaki Seiji , Yamahira Kazunori , Tokeshi Mutsunori 
Published: August 2002

AbstractThe patterns of sex change and spatial distribution in an intertidal holothurian, Polycheira rufescens (Chiridotidae; Echinodermata), were investigated on a stony beach in Amakusa, western Kyushu. Field caging experiments revealed that some individuals of P. rufescens underwent a sequential sex change from male to female via hermaphrodite stages and back to male again within a single reproductive season. The sex ratio of the population gradually changed from male dominance at first to equal proportions of males and females as the reproductive season progressed. Toward the end of the reproductive season, immature or spent individuals increased in proportion. Stone size appeared to be an important factor affecting the occurrence of P. rufescens individuals on a stony beach. Analysis of spatial distribution by means of Morisita's index of dispersion and nearest neighbor distances indicated that (i) males showed a slightly stronger tendency to aggregate than females, while females had a tendency toward uniform distribution; (ii) females tended to attract males, as shown by relatively short female‐to‐male distances; and (iii) there was a substantial variation in male‐to‐female distances, such that some males were positioned close to females while others were not. It may be suggested that spatial distribution of P. rufescens individuals during the reproductive period is partly dictated by the differential needs of individuals of different sexual states.
A unified adaptive oculomotor control model
Authors: Zhang Xiaolin , Wakamatsu Hidetoshi 
Published: August 2002

AbstractIn order to understand mechanisms of oculomotor control systems, an oculomotor model based on eye's anatomical structure and physiological mechanism is developed. In this model, various types of eye movements are considered, and two learning systems, one based on adaptive characteristics of flocculus and the other on vestibular nuclei's are developed. The role of neural paths from ocular muscle stretch receptors into flocculus, which were thought to not contribute in eye movement, is discussed in detail from the viewpoint of system control engineering. The experimental results through simulation show good control performance of the proposed model. Copyright © 2001 John Wiley & Sons, Ltd.
Estimating own and cross brand price elasticities, and price–cost margin ratios using store‐level daily scanner data
Authors: Kinoshita Junko , Suzuki Nobuhiro , Kawamura Tamotsu , Watanabe Yasuhito , Kaiser Harry M. 
Published: August 2002

AbstractThis article addresses three issues related to Japanese dairy demand analysis. First, an econometric fluid milk demand model is estimated using store‐level daily scanner data to determine whether the own‐price elasticities are significantly different from previous estimates based on aggregate market‐level data. This is important because of the current debate among Japanese dairy industry leaders concerning whether fluid milk is price inelastic or elastic. Own‐price elasticity differences between fresh and reconstituted milk products are also examined. Second, milk product cross‐price elasticities are estimated to measure the degree, if any, of substitutability between fresh milk and reconstituted milk products. Because most previous studies have relied upon aggregate market‐level data, there are no previous estimates of cross‐price elasticities for fresh milk and reconstituted milk products. Finally, price–cost margin ratios are estimated for each commodity using a method that does not require cost data, but rather relies on assumptions regarding the degree of competition to derive the price–cost margin ratio [Econlit alphanumeric subject codes: Q110, Q130]. © 2001 John Wiley & Sons, Inc.
The diagnosis of hairy cell leukemia can be established by flow cytometric analysis of peripheral blood, even in patients with low levels of circulating malignant cells
Authors: Cornfield Dennis B. , Mitchell Nelson Debra M. , Rimsza Lisa M. , Moller‐Patti Danielle , Braylan Raul C. 
Published: August 2002

AbstractThe diagnosis of hairy cell leukemia (HCL) has traditionally been based on microscopic means. Immunophenotypic analysis of peripheral blood by flow cytometry is not widely recognized as a method for diagnosing HCL, perhaps due to the expectation of low yield of neoplastic cells in patients who are characteristically leukopenic. The abnormal coexpression of CD103, CD25, and intense CD11c and CD20 on monotypic, slightly large B‐lymphocytes has previously been shown to be highly characteristic of HCL. We wished to determine if this pattern was valuable in the diagnosis of HCL in leukopenic patients with low levels of neoplastic cells in the peripheral blood. The abnormal immunophenotype above was observed in 25 peripheral blood specimens from patients with unexplained cytopenias or suspected lymphoproliferative processes. Ten of the 25 blood samples exhibited this abnormal phenotype in less than 5% of circulating leukocytes (ranging from <1% to 4%). All 10 patients had other manifestations of HCL, including cytopenias (mean white blood cell count, 1.8 × 103/mm3; hemoglobin, 11.0 gm/dl; platelets, 74 × 103/mm3), splenomegaly, and typical bone marrow morphologic changes. Eight of the 10 patients achieved an excellent response to one course of 2‐CDA, with significant improvement of cytopenias (mean white blood cell count: 5.3 × 103/mm3; hemoglobin: 14.4 g/dl; platelets: 181 × 103/mm3) and regression of splenomegaly. One patient had a partial response to alpha interferon and a subsequent complete response to 2‐CDA, and one died during treatment. In conclusion, flow cytometric immunophenotyping of peripheral blood is capable of detecting low levels of circulating malignant cells in HCL, even in leukopenic patients. As such, it can be a very useful, non‐invasive tool in the diagnosis of this disorder. Am. J. Hematol. 67:223–226, 2001. © 2001 Wiley‐Liss, Inc.
Response to: Mortality among rubber chemical manufacturing workers by M.M. Prince et al. Am. J. Ind. Med. 2000. 37: 590–598.
Authors: Velentgas Priscilla , Delzell Elizabeth , Toeppen‐Sprigg Barbara , Holtshouser Joseph L. 
Published: August 2002

AbstractMary M. Prince and colleagues [Prince et al., 2000] report that workers in the "rubber chemicals" manufacturing department of a plant in Niagara County, New York, have elevated ischemic heart disease (IHD) mortality compared with the US population, based on their observation of a standardized mortality ratio (SMR) for IHD of 1.51 (95% CI 0.94‐2.3). Despite the fact that the investigators also report SMRs for IHD mortality of 1.19 when compared with local Niagara County, NY referent rates and a rate ratio of 1.03 when workers exposed to rubber chemicals were compared with workers in other departments of the plant, most discussion and interpretation of these results focus on the comparison with US rates.
Radiation dose estimation for epidemiologic studies of flight attendants*
Authors: Grajewski Barbara , Waters Martha A. , Whelan Elizabeth A. , Bloom Thomas F. 
Published: August 2002

AbstractBackgroundNIOSH is conducting health studies of female flight attendants. Exposures of interest include cosmic radiation and circadian rhythm disruption, however, the data needed to estimate cumulative radiation dose are not found in work histories.MethodsWe developed an algorithm to generate from work histories the required input data for Federal Aviation Administration radiation estimation software and evaluated whether effects of cumulative radiation dose could be distinguished analytically from effects of circadian rhythm disruption.ResultsThe algorithm has relatively low bias (< 6%) for longer flights, which contribute most to cumulative radiation dose. In one NIOSH study, 44 crew incurred an estimated average annual occupational dose of 1.5–1.7 mSv. Selection of a study population flying predominantly North–South flights can provide the necessary distinction between radiation and time zone crossing exposures.ConclusionsMethods developed will be useful for exposure assessment in cabin crew studies with relatively short study periods, (e.g., reproductive health studies) for which limited flight history details are generally available. Am. J. Ind. Med. 41:27–37, 2002. © 2002 Wiley‐Liss, Inc.
Missense mutation of TRPS1 in a family of tricho‐rhino‐phalangeal syndrome type III
Authors: Kobayashi Hiromasa , Hino Megumu , Shimodahira Makiko , Iwakura Toshio , Ishihara Takashi , Ikekubo Katsuji , Ogawa Yoshihiro , Nakao Kazuwa , Kurahachi Hiroyuki 
Published: August 2002

AbstractWe report a new Japanese family with tricho‐rhino‐phalangeal syndrome type III (TRPS III) who have a missense mutation (Arg908Gln) of theTRPS1 gene (TRPS1) in affected individuals of the family. This study supports the notion that TRPS III results from missense mutations in exon 6 of TRPS1. © 2001 Wiley‐Liss, Inc.
Maternal complex chromosome rearrangement ascertained through a del (13)(q12.1q14.1) detected in her mildly affected daughter
Authors: Drummond‐Borg M. , Kulharya A.S. , Tonk V. , Garcia‐Heras J. 
Published: August 2002

AbstractA maternal complex chromosome rearrangement (CCR) involving chromosomes 2, 13, and 20 was ascertained in a normal female through the diagnosis of a deletion of 13q in her daughter. The child has mild clinical features and developmental delay consistent with proximal deletions of 13q that do not extend into band q32 and a del(13)(q12q14.1) that does not involve the retinoblastoma locus by FISH. Maternal studies by GTG banding and FISH showed a complex karyotype with bands 13q12.3→13q12.1::20p13 translocated to 2p13 and bands 2pter→2p13::13q12.3→13q14.1 translocated into band 20p13. This would be the first report of an interstitial deletion of 13q inherited from a parental complex chromosome rearrangement. © 2001 Wiley‐Liss, Inc.
De novo partial duplication of chromosome 7p in a male with autistic disorder
Authors: Wolpert C.M. , Donnelly S.L. , Cuccaro M.L. , Hedges D.J. , Poole C.P. , Wright H.H. , Gilbert J.R. , Pericak‐Vance M.A. 
Published: August 2002

AbstractWe describe a de novo partial duplication of 7p in a 25‐year‐old male with autistic disorder (AD). High‐resolution chromosome analysis revealed an extra segment added to the proximal short arm of chromosome 7. The G‐band pattern was consistent with an inverted duplication of 7p11.2‐p14.1. Fluorescent in situ hybridization (FISH), using a whole chromosome 7 DNA probe (Cytocell, Inc., UK), confirmed that the extra chromosome material is derived from chromosome 7, indicating that the patient is partially trisomic for a region of the short arm of chromosome 7. Partial duplication of the short arm of chromosome 7 is uncommon with little more than 30 cases in the literature. This is the first report of an individual with a 7p duplication who also has AD. © 2001 Wiley‐Liss, Inc.
Absence of a significant linkage between Na+,K+‐ATPase subunit (ATP1A3 and ATP1B3) genotypes and bipolar affective disorder in the old‐order Amish
Authors: Philibert R.A. , Cheung D. , Welsh N. , Damschroder‐Williams P. , Thiel B. , Ginns E.I. , Gershenfeld Howard K. 
Published: August 2002

AbstractPrevious studies provide evidence for a genetic component for susceptibility to bipolar affective disorder (BPAD) in the old‐order Amish population. El‐Mallakh and Wyatt [1995: Biol Psychiatry 37:235–244] have suggested that the Na+,K+‐ATPase may be a candidate gene for BPAD. This study examines the relationship between BPAD in the old‐order Amish cohort and the Na+,K+‐ATPase α1 and β3 subunit genes (ATP1A3, ATP1B3). A total of 166 sibling pairs were analyzed for linkage via nonparametric methods. Suggestive levels of statistical significance were not reached in any stratification model for affective illness. Overall, the results do not support linkage of bipolar disorder to the Na+,K+‐ATPase alpha subunit gene (ATP1A3) and beta subunit gene (ATP1B3) in these old‐order Amish families and they show that these Na+,K+‐ATPase subunit genes are not major effect genes (≥fourfold increased genetic risk of disease) for BPAD in the old‐order Amish pedigrees. We cannot exclude other genetic variants of the Na+,K+‐ATPase hypothesis for BPAD, whereby other loci may modifying Na+,K+‐ATPase activity. © 2001 Wiley‐Liss, Inc.
Association study of serotonin transporter gene regulatory region polymorphism and alcoholism
Authors: Matsushita Sachio , Yoshino Aihide , Murayama Masanobu , Kimura Mitsuru , Muramatsu Taro , Higuchi Susumu 
Published: August 2002

AbstractPrevious studies have indicated associations between a functional biallelic repetitive element in the 5′ regulatory region of the serotonin transporter gene (5‐HTTLPR) and alcoholic subjects who have either dissocial personality disorder or severe withdrawal symptoms. To replicate these associations under the hypothesis that genetic polymorphism plays some role in the susceptibility or vulnerability of some subgroup of alcoholics, the associations between alcoholic subjects' genetic polymorphisms, clinical characteristics, and personality traits were examined. This case control study comprised 697 alcoholic and 270 control subjects. A questionnaire focusing on family and social background, history of drinking and alcohol withdrawal, DSM‐III‐R criteria for the evaluation of psychiatric conditions, and Feighner's criteria for the lifetime diagnosis and assessment of overall severity of alcoholism was administered to 373 alcoholic subjects. Temperament and Character Inventory (TCI) and Sensation Seeking Scale (SSS) were used to evaluate the other 324 alcoholics. The frequency of the homozygous short allele was significantly higher in alcoholic binge drinkers than in nonbinge drinking alcoholics. There were no significant differences in the frequencies of either the 5‐HTTLPR genotype or the short vs. long allele in alcoholic and control subjects. The alcoholics' 5‐HTTLPR genotype and allele frequencies did not differ significantly by the severity of withdrawal symptoms or by the number of positive Feighner's diagnostic criteria. Although these results indicate an association between 5‐HTTLPR and a subgroup of alcoholics characterized by binge drinking, the authors found no differences in SSS and TCI subscale scores for alcoholics with different 5‐HTTLPR genotypes. Future studies of the association in other alcoholic population should take into account personality traits. © 2001 Wiley‐Liss, Inc.
Genetic variation of the human glycine receptor subunit genes GLRA3 and GLRB and susceptibility to idiopathic generalized epilepsies
Authors: Sobetzko Diana , Sander Thomas , Becker Cord‐Michael 
Published: August 2002

AbstractAlterations of glycine receptor α1 and β subunit genes have been associated with hypertonic motor disorders in both mice and humans. Mutations in genes encoding other ligand‐ and voltage‐gated ion channels have been identified in rare monogenic forms of idiopathic generalized epilepsies (IGE). We tested the hypothesis that allelic variants of the glycine receptor subunit genes, GLRA3 and GLRB, both localized on chromosome 4q, confer susceptibility to common subtypes of IGE. Mutation screening was carried out in index patients of 14 IGE families. No pathogenic mutation was found, but two intronic polymorphisms were detected in the GLRB gene, and four intronic, three exonic, and one 3′‐UTR polymorphisms were identified for the GLRA3 gene. Subsequent screening for exonic and 3′‐UTR polymorphisms in GLRA3 showed no statistical difference between a group of sporadic IGE patients (n = 104) and a control group (n = 141). The genotype frequencies for exonic and 3′‐UTR polymorphisms in GLRA3 showed no statistically significant difference between IGE patients (n = 104) and an ethnically matched control group (n = 141). Thus, no association between IGE and alterations in GLRA3 or GLRB genes could be detected, indicating that both genes do not play a major causative role in the epileptogenesis of common IGE subtypes. Still, these novel single nucleotide polymorphisms may be useful markers for candidate gene analyses of other disorders. © 2001 Wiley‐Liss, Inc.
Association study of a promoter polymorphism of UFD1L gene with schizophrenia
Authors: De Luca Alessandro , Pasini Augusto , Amati Francesca , Botta Annalisa , Spalletta Gianfranco , Alimenti Serenella , Caccamo Francesca , Conti Emanuela , Trakalo Joseph , Macciardi Fabio , Dallapiccola Bruno , Novelli Giuseppe 
Published: August 2002

AbstractSchizophrenia or schizoaffective disorders are often found in patients affected by DiGeorge/velo‐cardio‐facial syndrome (DGS/VCFS) as a result of hemizygosity of chromosome 22q11.2. We evaluated the UFD1L gene, mapping within the DGS/VCFS region, as a potential candidate for schizophrenia susceptibility. UFD1L encodes for the ubiquitin fusion degradation 1 protein, which is expressed in the medial telencephalon during mouse development. Using case control, simplex families (trios), and functional studies, we provided evidence for association between schizophrenia and a single nucleotide functional polymorphism, −277A/G, located within the noncoding region upstream the first exon of the UFD1L gene. The results are supportive of UFD1L involvement in the neurodevelopmental origin of schizophrenia and contribute in delineating etiological and pathogenetic mechanism of the schizophrenia subtype related to 22q11.2 deletion syndrome. © 2001 Wiley‐Liss, Inc.
Encyclopedia of human evolution and prehistory
Authors: McHenry Henry M. 
Published: August 2002

AbstractReview of Encyclopedia of Human Evolution and Prehistory, Second Edition edited by Eric Delson, Ian Tattersall, John A. Van Couvering, and Alison S. Brooks. New York, Garland Publishing, 2000, xiv + 753 pp, maps, charts, tables, drawings, photos, $175.
Effectiveness of human microsatellite loci for assessing paternity in a captive colony of vervets (Chlorocebus aethiops sabaeus)
Authors: Newman Timothy K. , Fairbanks Lynn A. , Pollack Deborah , Rogers Jeffrey 
Published: August 2002

AbstractMicrosatellite polymorphisms are playing an increasingly vital role in primatological research, and are particularly useful for paternity exclusion in both wild and captive populations. Although vervet monkeys (Chlorocebus aethiops) are commonly studied in both settings, few previous studies have utilized microsatellite markers for assessing genetic variation in this species. In a pilot project to assess paternity in the UCLA‐VA Vervet Monkey Research Colony (VMRC), we screened 55 commercially available human microsatellite markers chosen from a panel of 370 that have been shown to be polymorphic in baboons (Papio hamadryas). Using a standard PCR protocol, 43 (78%) loci produced amplifiable product. Of these, 14 were polymorphic and 11 were genotyped in 51 individuals, including 19 offspring and 14 potential sires. The average heterozygosity across the 11 loci was .719. In all 19 paternity cases all but one male was excluded as the true sire at two or more loci. This includes successfully distinguishing between two maternal half‐sib brothers who were potential sires in most of the paternity cases. Given that the colony is descended from 54 wild‐caught founders trapped between 1975 and 1987 from an introduced population on St. Kitts, West Indies, these values imply high microsatellite variability in natural vervet populations. Our results provide a panel of markers derived from the human genome that is suitable for assessing genetic variation and paternity in vervets. Am. J. Primatol. 56:237–243, 2002. © 2002 Wiley‐Liss, Inc.
Demography and pedigree structure of an SPF colony of rhesus monkeys (Macaca mulatta)
Authors: Ludvico Lisa , Slifer Susan , Massey Kristina , Mosman Kathryn , Mohamed Carlos , Stone William , Keeling Michale , Bernacky Bruce , Dyke Bennett 
Published: August 2002

AbstractThe SPF rhesus colony at the M.D. Anderson Cancer Center in Bastrop, Texas, was analyzed with the aim of determining the demographic and genetic effects of stringent selection for virus‐free breeders, permanent quarantine, continued surveillance, and culling of animals that show evidence of viral infection. The analysis shows minimal effects on population viability and loss of genetic variability in comparison with the traditionally managed (non‐SPF) portion of the population. Am. J. Primatol. 53:155–165, 2001. © 2001 Wiley‐Liss, Inc.
Micro and sub‐micro fabrication techniques for optically confined structures based on lithium fluoride
Authors: Montereali R. M. , Mancini A. , Martelli S. , Menchini F. , Picozzi P. 
Published: August 2002

AbstractLithium fluoride (LiF) films treated by low‐energy electrons represent a very promising candidate for the realization of miniaturized broad band optical devices like active waveguides and microcavities. The main properties, in particular the refractive index, density, structure and microstructure, of polycrystalline LiF films grown by thermal evaporation on amorphous and crystalline substrates are discussed, together with their influence on colour centres formation induced by low‐energy electron beam bombardment and on the choice­of the main irradiation conditions. Copyright­© 2001 John Wiley & Sons, Ltd.
Use of mass spectroscopic techniques to elucidate the nature of the products of the oxidation of trimethylstibine in air
Authors: Craig P. J. , Forster S. A. , Jenkins R. O. , Lawson G. , Miller D. , Ostah N. 
Published: August 2002

AbstractIn view of the biological production of trimethylstibine ((CH3)3Sb) in the natural environment, the fate of this species when exposed to ambient oxygen has been studied. The results obtained show that the oxidation process leads to a complex series of products. Trimethylstibine oxide ((CH3)3SbO) and a range of cyclic and linear oligomers have been detected using positive ion electrospray and atmospheric pressure chemical ionization techniques and the mass spectroscopic (MS) features are discussed. Dimethyl antimony ((CH3)2Sb) species were not detected under the conditions used. The results from both MS techniques were similar. Copyright © 2001 John Wiley & Sons, Ltd.