bluuebunny/crossref_metadata_2025_split huggingface dataset:
A nomogram to predict postoperative new-onset cerebral infarction after revascularization of moyamoya disease in adults and its validation: a retrospective study
Authors: Wang Zhen , Yu Jiacheng , Zhang Yu , Ruan Jiaping , Liu Xiaojie , Ma Sijia , Xie Jun , Wu Mimi , Bo Jinhua , Sun Yu’e 
Published: January 2025

BackgroundThe new-onset cerebral infarction is frequent after revascularization of moyamoya disease (MMD) in adults, serving as a major public health issue worldwide. The present study aims to construct a nomogram to predict postoperative new-onset cerebral infarction (POCI) after revascularization of adult MMD.Materials and methodsClinical data of 653 cases of adult MMD treated with revascularization were retrospectively analyzed. They were randomly divided into a training set (n = 457) and a validation set (n = 196) at a ratio of 7:3. Based on the risk factors of POCI after revascularization of adult MMD identified by logistic regression analysis and the corresponding regression coefficients, a nomogram was constructed. Its performance to predict POCI after revascularization of adult MMD was validated by calculating the area under the curve (AUC) and the decision curve analysis.ResultsUnivariate and multivariate logistic regression analyses showed that preoperative cerebral infarction (OR 2.548, 95% CI 1.357–4.787; p = 0.004), posterior cerebral artery anomalies (OR 2.106, 95% CI 1.157–3.834; p = 0.015), post-transit arterial development (OR 2.983, 95% CI 1.336–6.661; p = 0.008), pre-anesthesia mean arterial pressure &gt; 102.830 mmHg (OR 3.329, 95% CI 1.938–5.721; p &lt; 0.001), total operating time &gt; 212.500 min (OR 2.256, 95% CI 1.239–4.140; p = 0.008), preoperative fibrinogen level &gt; 2.750 g/L (OR 1.852, 95% CI 1.072–3.200; p = 0.027), and mean corpuscular hemoglobin concentration (OR 1.021, 95% CI 1.001–1.040; p = 0.038) were independent risk factors of POCI after revascularization of adult MMD. The AUC was 0.772 (95% CI 0.714–0.772) in the training set, and 0.718 (95% CI 0.603–0.833) in the validation set.ConclusionCollectively, the newly established nomogram effectively and intuitively predicts the POCI after revascularization of adult MMD.Clinical trial registrationwww.chictr.org, identifier ChiCTR2400087946.
A cohort study of serum 25-hydroxyvitamin D levels and the risk of hyperlipidaemia in adults
Authors: Liu Zi-yue , Liu Sha , Yao Xue , Wang Chun-yang , Song Yunhao , Bi Yan-ming , Wang Jin-Xiu , Li Yang , Shi Ta-la , Mi Wei , Chen Caiyun , Hu Zhi-Yong 
Published: January 2025

ObjectiveThis study aims to investigate the potential association between serum 25(OH)D levels and the risk of hyperlipidemia in adults through a prospective cohort study conducted in Zhejiang Province.MethodsBaseline surveys and follow-up studies were conducted to collect and analyze follow-up data over a three-year period. Vitamin D deficiency was defined as 25(OH)D &lt; 20 ng/mL, insufficiency as 20–29 ng/mL, and sufficiency as 25(OH)D ≥ 30 ng/mL. Hyperlipidemia or dyslipidemia was defined as the presence of hypercholesterolemia, hypertriglyceridemia, or both. The relationship between demographic characteristics and the incidence of hyperlipidemia among the study participants was explored.ResultsA total of 1,210 participants were included in this study, with 43.80% being male. The mean age of the participants was 51.84 ± 14.37 years, and the average serum 25(OH)D level was 25.89 (21.50, 29.82) ng/mL. A significant difference in the proportion of vitamin D deficiency was observed between males and females (22.06% vs. 10.94%, p &lt; 0.001). Vitamin D deficiency and insufficiency were prevalent among the middle-aged and elderly population (78.24%). Significant differences were found between the two groups in multiple sociodemographic variables, behavioral factors, and metabolic risk factors (p &lt; 0.05). The incidence of hyperlipidemia among vitamin D-deficient individuals was 1.612 times higher than that among vitamin D-sufficient individuals (95% confidence interval [CI]: 1.228–2.116; p &lt; 0.001). After fully adjusting for confounding factors, the multivariate-adjusted hazard ratio (HR) was 1.572 (95% CI: 1.187–2.08; p = 0.002), indicating a difference in the incidence of hyperlipidemia across different serum vitamin D levels.ConclusionThis cohort study reveals a significant association between serum 25(OH)D levels and the incidence of hyperlipidemia. Additionally, lifestyle factors associated with vitamin D deficiency are also correlated with the incidence of hyperlipidemia. These findings provide further evidence for improving blood lipid profiles through adjustments in vitamin D intake or related lifestyle modifications.
Mature tertiary lymphoid structure associated CD103+ CD8+ Trm cells determined improved anti-tumor immune in breast cancer
Authors: Fang Qin , Chen Shuru , Chen Xiaoyue , Zou Wei , Chen Di , Huang Yukang , Wu Chucheng 
Published: January 2025

BackgroundAlthough tertiary lymphoid structures (TLS) play crucial roles in the anti-tumor immune response and are associated with favorable prognoses in many solid tumors, the precise mechanisms by which TLSs enhance anti-tumor immunity remain poorly understood. The current study aimed to explore the relationship between the maturity of tertiary lymphoid structures and their key immune cells in combating breast cancer.Patients and methodsIn this study, we utilized immunofluorescence and H&amp;E staining to detect tumor-resident memory T cells (Trm) and assess the maturity of TLS, analyzing their distribution and proportion in an annotated cohort of 95 breast cancer patients.ResultsThe presence of tumor-associated TLSs was correlated with an improved prognosis in patients with breast cancer. The proportion of CD8+CD103+ resident memory T cells and natural killer (NK) cells within the TLSs was significantly higher than that in areas outside of these structures. Additionally, the proportions of CD103+ CD8+ Trm cells and NK cells were significantly increased with the gradual maturation of TLS. Furthermore, the secretion function of effector molecules by CD8+ CD103+ Trm cells and NK cells within TLSs was significantly enhanced, indicating a strong correlation between the effector function of CD103+ CD8+ Trm and NK cells and the maturity of TLSs.ConclusionOur study identifies potential additional prognostic information for the clinical prognosis of breast cancer patients, underscoring the prognostic significance of immune cells within TLS, with a particular focus on CD103+ CD8+ Trm cells and NK cells.
Effect of a mindfulness-based cognitive behavior therapy intervention on occupational burnout among school teachers
Authors: Paudel Netra Raj , K. C. Prakash , Nygård Clas-Håkan , Neupane Subas 
Published: January 2025

BackgroundWe aimed to assess the effect of mindfulness-based cognitive behavior therapy (MB-CBT) as an intervention to reduce burnout among secondary school teachers in Nepal.MethodsThe baseline survey of this randomized controlled trial included 218 secondary school teachers from 37 schools in Kathmandu. At a one-month follow-up, 192 teachers completed post-test survey. The Maslach Burnout Inventory for Educators (MBI-ES) tool was used to measure burnout in three dimensions: emotional exhaustion (EE), depersonalization (DP), and personal accomplishment (PA). Teachers in the treatment arm (n=102) received MB-CBT, while those in the control arm (n=116) continued their regular activities. Linear regression models with generalized estimating equations were used to calculate the mean, mean change estimates, and their 95% confidence intervals (CIs).ResultsThe mean level of EE decreased during the post-test for both treatment (mean change -0.93, 95% CI: -2.56 to 0.70) and control (-1.71, 95% CI: -3.24 to -0.18) arms. The mean level of DP also decreased in the treatment arm (-0.12, 95% CI: -0.98 to -0.75), but a sharper decline was observed in the control arm (-1.97, 95% CI: -2.78 to -1.16). The mean level of PA increased in both the treatment (1.04, 95% CI: -0.21 to 2.30) and control (1.53, 95% CI: 0.35 to 2.70) arms.ConclusionsThe prevalence of high EE and low PA decreased in both arms. However, the prevalence of high DP remained constant in the treatment arm but sharply decreased in the control arm. No significant differences between the arms were found in the post-test mean levels of EE, DP, and PA. The virtual MB-CBT intervention showed no significant impact on reducing burnout. Nonetheless, small reductions in burnout were observed in both groups.
In silico development of a multi-epitope-based vaccine against Burkholderia cepacia complex using reverse vaccinology
Authors: Ghorbani Donya , Beig Masoumeh , Noori Goodarzi Narjes , Sholeh Mohammad , Shahbazi Behzad , Moghaddam Yaser , Badmasti Farzad 
Published: January 2025

BackgroundMultidrug-resistant Burkholderia cenocepacia and Burkholderia multivorans have emerged as significant pathogens, particularly in patients with cystic fibrosis (CF) and chronic granulomatous disease (CGD).ObjectiveGiven the absence of approved vaccines, this study aimed to identify potential vaccine candidates against these pathogens.MethodsThe complete genomes of B. cenocepacia and B. multivorans were retrieved from the GenBank. Surface-exposed proteins that were antigenic, non-allergenic, and non-homologous to human proteins were selected for further analysis. The conserved domains of the selected proteins were analyzed, and their presence was examined across 68 genomes. Subsequently, linear and conformational B-cell epitopes and human MHC II binding sites were identified. Highly conserved and immunogenic B-cell epitopes from outer membrane proteins (OMPs) were incorporated into a multi-epitope vaccine (MEV). Molecular docking analysis was performed to assess the interaction of the selected proteins. Finally, molecular dynamics (MD) simulations were conducted using GROMACS 2019 to evaluate the feasibility and dynamics of the interactions between the chimeric MEV and Toll-like receptor complexes, TLR2 and TLR4.ResultsOf 16,723 proteins identified in B. multivorans and B. cenocepacia strains, nine proteins (six OMPs and three extracellular) were selected as ideal candidates based on established criteria. These proteins had a molecular weight of 110 kDa and were present in ≥ 75% of the dataset of B. multivorans and B. cenocepacia genomes. In addition, molecular docking and MD indicated stable and feasible interactions between MEV and TLRs. The MEV-TLR4 system demonstrates the greatest stability and tightly bound interaction, with minimal fluctuations and high structural integrity. In contrast, the MEV-only system exhibits significant flexibility and dynamic behavior as a free ligand, while the MEV-TLR2 system balances stability and flexibility, showing a dynamic but stable interaction.ConclusionNine potential immunogenic proteins were identified as viable targets for vaccine development. An optimized MEV was explicitly designed for B. multivorans and B. cenocepacia. The novel MEV platform exhibited high binding affinity to immune receptors and favorable molecular docking characteristics. Although these findings are encouraging, additional in vitro and in vivo testing is necessary to validate the vaccine’s effects.
Short-Wave Infrared Spectroscopy for On-Site Discrimination of Hazardous Mineral Fibers Using Machine Learning Techniques
Authors: Bonifazi Giuseppe , Bellagamba Sergio , Capobianco Giuseppe , Gasbarrone Riccardo , Lonigro Ivano , Malinconico Sergio , Paglietti Federica , Serranti Silvia 
Published: January 2025

Asbestos fibers are well-known carcinogens, and their rapid detection is critical for ensuring safety, protecting public health, and promoting environmental sustainability. In this work, short-wave infrared (SWIR) spectroscopy, combined with machine learning (ML), was evaluated as an environmentally friendly analytical approach for simultaneously distinguishing the asbestos type, asbestos-containing materials in various forms, asbestos-contaminated/-uncontaminated soil, and asbestos-contaminated/-uncontaminated cement, simultaneously. This approach offers a noninvasive and efficient alternative to traditional laboratory methods, aligning with sustainable practices by reducing hazardous waste generation and enabling in situ testing. Different chemometrics techniques were applied to discriminate the material classes. In more detail, partial least squares discriminant analysis (PLS-DA), principal component analysis-based discriminant analysis (PCA-DA), principal component analysis-based K-nearest neighbors classification (PCA-KNN), classification and regression trees (CART), and error-correcting output-coding support vector machine (ECOC SVM) classifiers were tested. The tested classifiers showed different performances in discriminating between the analyzed samples. CART and ECOC SVM performed best (RecallM and AccuracyM equal to 1.00), followed by PCA-KNN (RecallM of 0.98–1.00 and AccuracyM equal to 1.00). Poorer performances were obtained by PLS-DA (RecallM of 0.68–0.72 and AccuracyM equal to 0.95) and PCA-DA (RecallM of 0.66–0.70 and AccuracyM equal to 0.95). This research aligns with the United Nations’ Sustainable Development Goals (SDGs), particularly SDG 3 (Good Health and Well-Being), by enhancing human health protection through advanced asbestos detection methods, and SDG 12 (Responsible Consumption and Production), by promoting sustainable, low-waste testing methodologies.
Identifying Research Priorities for Cognition in CKD
Authors: Alexiuk Jamie , Harasemiw Oksana , Vanderlinden Jessica , Verrelli Davide , Tarca Brett , Collister David , Ribeiro Heitor , Corradetti Bonnie , Fowler Kevin , Manfredini Fabio , McAdams-DeMarco Mara , Chu Nadia , Jesudason Shilpa , McKeaveney Clare , Leon Silvia J. , Anandh Urmila , Tollitt James , Thompson Stephanie , Dasgupta Indranil , Bohm Clara 
Published: January 2025

Background:
Cognition is a research priority for people living with chronic kidney disease (CKD), but identification of critical research questions is lacking. This study aimed to determine which cognition-related research questions are most important to CKD stakeholders.

Methods:
A modified Delphi technique with 3 survey rounds was used. The study sample included 3 panels (People with lived CKD experience, Researchers, and Clinicians) recruited through international patient and kidney research networks, kidney societies, and snowball sampling with email invitations. Survey rounds were distributed electronically through REDCap. In Round 1 (October 2021-May 2022), respondents contributed three important research questions regarding cognition in CKD (free text). After deduplication and qualitative synthesis, respondents ranked the importance of these questions on a nine-point Likert scale in Round 2 (Feb-April 2023). Questions with mean and median ratings of >7 by at least two respondent panels or rated critically important by the ‘lived experience’ panel were re-ranked in Round 3 ( Aug-Sept 2023) and assessed for consensus to identify the final list of priority research questions.

Results:
Respondents (n=152) identified 125 and 44 discrete questions after Rounds 1 and 2, respectively. The final shortlist included 27 questions in 8 categories. The most critical research question identified was “What factors
prevent
cognitive impairment in people receiving dialysis?” Overall, respondents prioritized questions focusing on prevention and treatment of cognitive impairment. Scores between the panels were significantly different for 16 questions. Those with lived CKD experience prioritized quality of life, researchers emphasized developing interventions to mitigate cognitive impairment, and clinicians prioritized the effect of CKD treatment on cognitive impairment.

Conclusions:
Through an established consensus methodology involving key stakeholder groups, we identified 27 critical research questions about cognition in CKD. These questions should guide future study design and outcome selection.
РАСПРОСТРАНЁННОСТЬ ВРОЖДЕННОГО ИХТИОЗА В АЗЕРБАЙДЖАНСКОЙ РЕСПУБЛИКЕ ЗА 2017-2023 гг.
Authors: Махмудов Ф.Р. , Амирова И.А. , Мамедова В.А. 
Published: January 2025

В статье представлена информация об исследованиях, проведенных с целью изучения распространенности врожденного ихтиоза (ВИ) в Азербайджанской Республике. Ретроспективное исследование проведено на основании документов пациентов, состоящих на учете в Республиканском дерматовенерологическом центре Азербайджана и Детском дерматовенерологическом диспансере №1 в 2017-2023 годах. По результатам статистического анализа пиковые случаи зафиксированы у 309 больных (67,47%) из 458 больных ранним BИ, зарегистрированных в 2021-2023 гг. Среди больных преобладали лица мужского пола – 363 пациента (79,26%), а среди детей и подростков в возрастной категории 2-12 лет – 133 (63,94%). полученные результаты определяет высокую социальную значимость данной проблемы и необходимость проведения достойного медицинского обследования и лечения пациентов с ВИ согласно современным стандартам в рамках государственной программы.
Məqalədə Azərbaycan Respublikasında anadangəlmə ixtiozun (Aİ) yayılmasını öyrənmək məqsədilə aparılmış tədqiqatı işi haqqında məlumat verilmişdir. Tədqiqat 2017-2023-cü illər ərzində Azərbaycan Respublikası Dəri-Zöhrəvi Mərkəzində və 1№-li Uşaq Dəri-Zöhrəvi Dispanserində qeydiyyatda olan xəstələrin sənədləri əsasında aparılmışdır. Statistik təhlilin nəticələrinə görə, 2021-2023-cü illərdə qeydiyyatda olan 458 erkən Aİ xəstəsindən 309 nəfərdə (67,47%) pik halları qeydə alınıb. Xəstələr arasında kişi cinsindən olanlar üstünlük təşkil etmişdir – 363 xəstə (79,26%) və 2-12 yaş kateqoriyasında uşaqlar və yeniyetmələr arasında yayılma tezliyi – 133 (63,94%) olmuşdur. Məqalədə müəlliflər bu problemin aradan qaldırılması və dövlət proqramı çərçivəsində Aİ xəstələrinin müasir standartlara uyğun tibbi müayinə və müalicəsinin zəruriliyini qeyd edirlər.
The article provides information on the research conducted to study the prevalence of congenital ichthyosis (CI) in the Republic of Azerbaijan. The retrospective study was conducted on the basis of the documents of patients registered at the Republic Dermatology-Venereal Center of Azerbaijan and Children's Dermatology-Venereal Dispensary №1 during 2017-2023. According to the results of the statistical analysis, peak cases were recorded in 309 patients (67.47%) out of 458 early AI patients registered in 2021-2023. Males predominated among the patients - 363 patients (79.26%), and the prevalence among children and adolescents in the 2-12 age category was 133 (63.94%). The authors emphasize the necessity of this issue and underline the importance of implementing modern diagnostic and treatment standards for CI patients within the framework of a state program.
A RARE CASE OF UNCLASSIFIED CARCINOMA OF THE LUNG: DIAGNOSTIC CHALLENGES
Authors: Fylenko B.M. , Royko N.V. , Starchenko I.I. , Starchenko O.V. , Horodynska O.Y. , Proskurnia S.A. 
Published: January 2025

The article provides information about a case of pseudomesotheliomatous lung carcinoma, which was clinically undiagnosed but confirmed postmortem through immunohistochemical analysis during differential diagnosis. In the reported case, the diagnosis making was a challenge to physicians, and, therefore, this case deserves attention from surgeons, oncologists and pathologists. Pseudomesotheliomatous carcinoma of the lung is a rare malignant lung tumor, but it should always be kept in mind until the final diagnosis is made in the differential diagnosis of pulmonary disease involving the pleura, especially in the presence of pleural effusion. Nonetheless the poor prognosis and lack of effective treatment approaches, the study of this tumor will further improve the survival of patients and improve the differential diagnosis, since the diagnosis depends mainly on its immunohistochemical verification.
Məqalədə sağ ikən klinik diaqnozu qoyulmayan, yalnız ölümündən sonrakı diferensial diaqnostika prosesində immunohistokimyəvi analiz vasitəsilə diaqnozu dəqiqləşdirilən ağciyərin psevdomezotetiomatoz karsinoması xəstəsi haqqında məlumat verilmişdir. Bu xəstəlik diaqnostikasının çətinliyinə görə cərrah, onkoloq və patoloqanatomlardan xüsusi diqqət tələb edilir. Psevdomezoteliomatoz ağciyər karsinoması nadir rast gəlinən şiş xəstəliyidir. Buna görə plevranın zədələnməsi ilə və xüsusən də plevrada ekssudat toplanması ilə müşayiət olunan xəstəliklər zamanı diferensial diaqnostika vasitəsilə xəstəyə diaqnoz qoyulduqda bu xəstəliyi də nəzərə almaq lazımdır. Bu xəstəliyin proqnozunun pis olmasına və effektiv müalicə metodunun olmamasına baxmayaraq, adı çəkilən şişin öyrənilməsi pasiyentlərin yaşama müddətinin artırmağa və diferensial diaqnostikanı yaxşılaşdırmağa imkan verə bilər. Nəzərə alınmalıdır ki, psevdomezotetiomatoz karsihomanın diaqnostikası əsasən şiş materialının immunohistokimyəvi analizindən asılıdır.
В статье сообщается о летальном случае клинически недиагностированной псевдомезотелиоматозной карциномы легкого, которая впоследствии была верифицирована посмертно в процессе дифференциальной диагностики с помощью иммуногистохимического анализа. В данном случае постановка диагноза представляла собой сложную задачу для врачей, поэтому этот случай заслуживает внимания хирургов, онкологов и патологоанатомов. Псевдомезотелиоматозная карцинома легкого является редкой злокачественной опухолью легкого, ее всегда следует иметь в виду до постановки окончательного диагноза при дифференциальной диагностике легочных заболеваний с поражением плевры, особенно при наличии плеврального выпота. Несмотря на плохой прогноз и отсутствие эффективных методов лечения, изучение этой опухоли позволит еще больше повысить выживаемость пациентов и улучшить дифференциальную диагностику, поскольку диагноз зависит в основном от ее иммуногистохимической верификации.
OS SENTIDOS DO TRABALHO NAS VOZES DE TRABALHADORES-ESTUDANTES DA EDUCAÇÃO DE JOVENS E ADULTOS – EJA
Authors: Pereira Darc Lene Braga , Castro Mad Ana Desiree Ribeiro de 
Published: January 2025

This article aims to understand the meanings attributed to work by the workers/students (TEs) of Youth and Adult Education (EJA). Through qualitative research, we conducted a semi-structured interview with seven workers/students enrolled in the 1st and 2nd segments of EJA in a public school in Santa Maria – DF. Based on the proposal of the meaning cores formulated by Aguiar, Soares and Machado (2015), and Aguiar and Ozella (2013), four meaning cores were constructed from the participants' reports. The synthesis of our analysis allowed us to infer: i. That the construction of meanings is mediated by the centrality of work in the ways of living and surviving, ii. The subjects of EJA carry relevant social marks in the processes of subjectivation of the worker-being in accordance with the social meanings valued from capitalist sociability, iii. Meanings that form them from the social experiences and knowledge learned at work emerged, configuring the ways of existing and resisting in the world.