bluuebunny/crossref_metadata_2025_split huggingface dataset:
The nationalization of the large-scale copper mines in Chile: successful investment or financial failure?
Authors: González Andrés , Sánchez Felipe , Castillo Emilio 
Published: December 2023

Abstract
Between 1967 and 1971, the Chilean government nationalized its large-scale copper mining industry. While this process is widely considered successful given the demonstrated long-term state capacity to profitably operate the assets, the discussion on its net financial convenience has usually been disregarded. Aiming to improve the understanding of this case of resource nationalism, this paper follows two complementary approaches. First, we provide a systematic review of the historical background, development, and short-term impact of the Chilean nationalization, consolidating at the same time the available financial data on fiscal inflows and outflows as part of this process. Secondly, we perform an ex-post NPV assessment using a 10% discount rate over the annual cash flows that the government has perceived from the nationalized mining operations from 1967 to 2022 and compare it with a hypothetical counterfactual scenario in which these mines would have remained privately owned. This yields a higher NPV of the Nationalization compared to the counterfactual. Considering that discount rates above 11.1% or operational cost reductions by 4.5% indicate a net financial loss, the results suggest that, purely from a financial perspective, the nationalization process was marginally positive for the government. We expect that this analysis provides support for a thoughtful mineral policy that contributes to sustainable human and economic development in resource-rich countries.
Tissue-specific populations from amniotic fluid-derived mesenchymal stem cells manifest variant in vitro and in vivo properties
Authors: Liu Nengqing , Cheng Yi , Wang Ding , Guan Hongmei , Chen Diyu , Zeng Juan , Lu Dian , Li Yuanshuai , Yang Yinghong , Luo Qian , Zhu Lifen , Jiang Bin , Sun Xiaofang , Song Bing 
Published: December 2023

AbstractAmniotic fluid derived mesenchymal stem cells (AFMSCs), shed along the fetal development, exhibit superior multipotency and immunomodulatory properties compared to MSCs derived from other somatic tissues (e.g., bone marrow and fat). However, AFMSCs display heterogeneity due to source ambiguity, making them an underutilized stem cells source for translational clinical trials. Consequently, there is an urgent need to identify a method to purify the AFMSCs for clinical use. We found that the AFMSCs can be categorized into three distinct groups: kidney-specific AFMSCs (AFMSCs-K), lung-specific AFMSCs (AFMSCs-L), and AFMSCs with an undefined tissue source (AFMSCs-X). This classification was based on tissue-specific gene expression pattern of single cell colony. Additionally, we observed that AFMSCs-X, a minority population within the AFMSCs, exhibited the highest multipotency, proliferation, resistance to senescence and immuno-modulation. Our results showed that AFMSCs-X significantly improved survival rates and reduced bacterial colony forming units (CFU) in cecal ligation and puncture (CLP)-induced septic mice. Therefore, our study introduces a novel classification method to enhance the consistency and efficacy of AFMSCs. These subpopulations, originating from different tissue source, may offer a valuable and innovative resource of cells for regenerative medicine purposes.
Recommendations for Women in Mountain Sports and Hypoxia Training/Conditioning
Authors: Burtscher Johannes , Raberin Antoine , Brocherie Franck , Malatesta Davide , Manferdelli Giorgio , Citherlet Tom , Krumm Bastien , Bourdillon Nicolas , Antero Juliana , Rasica Letizia , Burtscher Martin , Millet Grégoire P. 
Published: December 2023

AbstractThe (patho-)physiological responses to hypoxia are highly heterogeneous between individuals. In this review, we focused on the roles of sex differences, which emerge as important factors in the regulation of the body’s reaction to hypoxia. Several aspects should be considered for future research on hypoxia-related sex differences, particularly altitude training and clinical applications of hypoxia, as these will affect the selection of the optimal dose regarding safety and efficiency. There are several implications, but there are no practical recommendations if/how women should behave differently from men to optimise the benefits or minimise the risks of these hypoxia-related practices. Here, we evaluate the scarce scientific evidence of distinct (patho)physiological responses and adaptations to high altitude/hypoxia, biomechanical/anatomical differences in uphill/downhill locomotion, which is highly relevant for exercising in mountainous environments, and potentially differential effects of altitude training in women. Based on these factors, we derive sex-specific recommendations for mountain sports and intermittent hypoxia conditioning: (1) Although higher vulnerabilities of women to acute mountain sickness have not been unambiguously shown, sex-dependent physiological reactions to hypoxia may contribute to an increased acute mountain sickness vulnerability in some women. Adequate acclimatisation, slow ascent speed and/or preventive medication (e.g. acetazolamide) are solutions. (2) Targeted training of the respiratory musculature could be a valuable preparation for altitude training in women. (3) Sex hormones influence hypoxia responses and hormonal-cycle and/or menstrual-cycle phases therefore may be factors in acclimatisation to altitude and efficiency of altitude training. As many of the recommendations or observations of the present work remain partly speculative, we join previous calls for further quality research on female athletes in sports to be extended to the field of altitude and hypoxia.
Genome wide association study of Ethiopian barley for terminal drought stress tolerance under field and climate chamber conditions
Authors: Teklemariam Surafel Shibru , Bayissa Kefyalew Negisho , Matros Andrea , Pillen Klaus , Ordon Frank , Wehner Gwendolin 
Published: December 2023

AbstractIn order to detect markers for drought stress tolerance, field experiments in Ethiopia were conducted for three years at two naturally drought-prone locations and two optimum moisture locations using 239 Ethiopian barley landraces and 21 barley breeding lines. Furthermore, a climate chamber experiment applying drought stress at different water regimes (70% soil water capacity (WC) for control and 20% WC for drought stress conditions) after flowering was conducted for selected 196 accessions. Results revealed reduced grain biomass by 47% and 80% under field and climate chamber conditions, respectively, as well as significantly (p < 0.05) reduced days to maturity and plant height, in both experimental designs. Based on 10,644 SNP markers, GWAS was conducted to identify marker trait associations (MTA) for drought stress tolerance. For days to maturity, relative chlorophyll content, plant height, number of seeds per spike, thousand kernel weight, and harvest index under field and climate chamber drought stress treatments, 58 significant MTAs were identified. In total, 41.4% of the MTAs were located on chromosome 2H, of which one is very close to the Ppd-H1 flowering locus. These findings underpin the importance of this genome region for drought tolerance. Another MTA on chromosome 1H was detected for days to maturity under field drought stress treatment in the vicinity of the known flowering time ELF3 gene. Additionally, 13 and 3 Ethiopian landraces that tolerate severe and moderate drought stress in climate chamber and field experiments were identified, respectively, using drought indices. The results highlight the tolerance of Ethiopian landraces to different levels of drought stress as well as their potential to be considered in future barley improvement programs.
Protective effect of cilostazol on vascular injury in rats with acute ischemic stroke complicated with chronic renal failure
Authors: Sun Ru , Gu Qun , Zhang Xufeng , Zeng Ruiqi , Chen Dan , Yao Jingjing , Min Jingjing 
Published: December 2023

AbstractChronic renal failure (CRF) resulting in vascular calcification, which does damage to blood vessels and endothelium, is an independent risk factor for stroke. It has been reported that cilostazol has a protective effect on the focal cerebral ischemic infarct. However, its impact on vascular injury in CRF combined stroke and its molecular protection mechanism have not been investigated. In this study, we carried out the effect of cilostazol on CRF combined stroke rats, and the results confirmed that it improved the neurobehavior, renal function as well as pathologic changes in both the kidney and brain. In addition, the inflammation and oxidative stress factors in the kidney and brain were suppressed. Moreover, the rates of brain edema and infarction were decreased. The injured brain-blood barrier (BBB) was recovered with less Evans blue extravasation and more expressions of zonula occludens-1(ZO-1) and occludin. More cerebral blood flow (CBF) in the ipsilateral hemisphere and more expression of CD31 and vascular endothelial growth factor (VEGF) in brain and kidney were found in the cilostazol group. Furthermore, cell apoptosis and cell autophagy became less, on the contrary, proteins of vascular endothelial growth factor receptor 2 (VEGFR2) after the cilostazol treatment were increased. More importantly, this protective effect is related to the pathway of Janus Kinase (JAK)/signal transducer and activator of transcription 3 (STAT3), mammalian target of rapamycin (mTOR), and the hypoxia inducible factor-1α (HIF-1α). In conclusion, our results confirmed that cilostazol exerted a protective effect on the brain and kidney function, specifically in vascular injury, oxidative stress, cell apoptosis, cell autophagy, and inflammation response in CRF combined with stroke rats which were related to the upregulation of JAK/STAT3/mTOR signal pathway.
Anterolaterale Instabilität – Anatomie, Biomechanik und Therapiemöglichkeiten
Authors: Peez Christian , Herbst Elmar , Deichsel Adrian , Raschke Michael J. , Briese Thorben , Glasbrenner Johannes , Kittl Christoph 
Published: December 2023

ZusammenfassungTrotz einer anatomischen Rekonstruktion des vorderen Kreuzbands werden unverändert hohe Versagensraten sowie persistierende anterolaterale Instabilitäten beobachtet, sodass die anterolaterale Rotationsinstabilität vermehrt in den wissenschaftlichen und klinischen Fokus rückte. Für die Sicherung der anterolateralen Rotationsinstabilität ist der Tractus iliotibialis mit seinen tiefen Strukturen entscheidend, wobei auch knöcherne Faktoren zur Pathogenese der anterolateralen Instabilität beitragen. Entsprechend wird die Rekonstruktion des vorderen Kreuzbands im klinischen Alltag zunehmend durch zusätzliche anterolaterale extraartikuläre Rekonstruktionen ergänzt, was trotz des Risikos einer unphysiologischen Gelenkkinematik in den guten klinischen Kurzzeitergebnissen begründet ist. Mögliche Indikationen stellen Revisionsfälle oder Hochrisikokonstellationen dar, wobei die Langzeitfolgen dieser Prozeduren noch nicht abgeschätzt werden können.
Chihuahuan Desert Shrine Caves: Refining Chronologies of Religious Iconography and Social Histories for the Jornada and Mimbres Mogollon Regions of the North American Southwest
Authors: Miller Myles R. , Creel Darrell G. , Geib Phil R. 
Published: December 2023

AbstractThis article presents radiocarbon dates on 29 perishable objects deposited in shrine caves in the Jornada and Mimbres Mogollon regions of far west Texas and southern New Mexico. The dated objects include tablita fragments, effigies, prayer sticks, hafted projectile point foreshafts, and flat curved sticks. Analysis of the dates reveals three significant trends: a particular set of Indigenous ritual practices involving shrine caves in the North American Southwest was of extraordinary temporal depth and continuity; the meanings and material culture associated with shrine caves changed through time; and a signature iconographic expression of Jornada and Mimbres origin cosmologies, the Goggle-eye or “Tlaloc” entity, is older than previously understood. The dating of shrine caves and iconographic motifs provides new insights on early eras of religious expression in the southern Southwest, clarifying both the nature and time depth of foundational cosmologies and providing a deep time perspective for interpretations of how such cosmologies and their material and iconographic expressions changed through time.
Chronological Hygiene and Bayesian Modeling of Poverty Point Sites in the Lower Mississippi Valley, circa 4200 to 3200 cal BP
Authors: Kidder Tristram R. , Grooms Seth B. 
Published: December 2023

AbstractDevelopments in radiocarbon dating and analysis provide new opportunities to develop high-resolution chronologies to explore changes through time. We explore the temporality of what has been called the Poverty Point culture of the lower Mississippi Valley circa 4200 to 3200 cal BP, especially the chronology of the type site, Poverty Point. Because of its complicated material culture elaboration without evidence of agriculture, Poverty Point has been identified as the political and economic center of a complex archaeological culture. The duration of site occupation and the historical relationship between the type site and those assumed to be contemporary are critical variables for explaining the emergence of complexity at this time. Most interpretations require political or evolutionary processes that accumulate gradually over hundreds of years. Our data show, however, that there is no temporal coherence among so-called Poverty Point culture sites; among such sites, Poverty Point was occupied for a relatively short period, and it is younger than many sites thought to be derived from it. Using explicit radiometric hygiene and Bayesian analyses of dates, we reject the idea of a unified Poverty Point culture and argue instead that the Poverty Point site earthworks developed through rapid, punctuated events occurring circa 3300 to 3200 cal BP.
New Dynamics of the “Post-COVID-19 Era”: A Legal Conundrum
Authors: Vedaschi Arianna , Graziani Chiara 
Published: December 2023

AbstractIn this Article we analyze whether and how the legal reactions to COVID-19 brought permanent changes to three main areas that are at the very basis of the study of comparative constitutional law: the horizontal separation of powers in different forms of government; the vertical separation of powers and its effects on forms of state; and the reviewability of limitations to human rights and personal freedoms by bodies exercising constitutional review. Rather than just examining and categorizing the reactions, we search for the political, institutional, factual, and sometimes even cultural rationales at the basis of each trend. Our claim is that COVID-19 was a driving force for relevant changes in the three analyzed areas, but we also recognize that these changes did not come “out of the blue,” as they were already “latent” in considered legal systems. The analysis demonstrates that the traditional categories we use to classify the forms of government, forms of state, and the mechanisms of constitutional review, although being useful paradigms to study these topics, have in themselves the potential to be “stretched,” and even unhinged, when global and long-lasting emergencies, as COVID-19, are in place.
Toward an Agential Conception of Hermeneutical Injustice: Isolation and Domestic Violence
Authors: Dougherty Emma C. 
Published: December 2023

AbstractMiranda Fricker's definition of hermeneutical injustice entails that hermeneutical injustice is always structural and never agential, but I argue that hermeneutical injustice has an agential dimension that is evident in cases of domestic violence. This dimension becomes especially apparent when examining the experiences of knowers who are multiply nondominant. Centering this intersectional approach, I focus on domestic violence perpetrators who intentionally isolate their victims, preventing them from accessing the necessary conceptual resources to understand their experience as one of domestic violence. Recognizing the agential dimension not only has implications for our understanding of the range of harms suffered by victims of domestic violence but also invites further reflection on cases of hermeneutical injustice where the injustice is the direct result of an agent's actions or is even intentionally inflicted.
The impact of a blood-culture diagnostic stewardship intervention on utilization rates and antimicrobial stewardship
Authors: Wang Melinda C. , Zhou Kelvin J. , Shay Sabra L. , Herlihy James P. , Siddique Muhammad A. , Trevino Castillo Sergio , Lasco Todd M. , Barrett Miriam , Al Mohajer Mayar 
Published: December 2023

AbstractBlood-culture overutilization is associated with increased cost and excessive antimicrobial use. We implemented an intervention in the adult intensive care unit (ICU), combining education based on the DISTRIBUTE algorithm and restriction to infectious diseases and ICU providers. Our intervention led to reduced blood-culture utilization without affecting safety metrics.
Understanding Shield Laws
Authors: Cohen David S. , Donley Greer , Rebouché Rachel , Aubrun Isabelle 
Published: December 2023

AbstractIn anticipation of extraterritorial application of antiabortion laws, many states have enacted laws that attempt to shield abortion providers, helpers, and patients from civil, professional, or criminal liability associated with legal abortion care. This essay analyzes and compares the statutory schemes of the seven early adopting shield states: California, Connecticut, Delaware, Illinois, Massachusetts, New Jersey, and New York. After describing what the laws do and how they operate, we offer reflections on coming disputes, areas of legal uncertainty, and ways to improve future shield laws.
Providing the Gist of Medical Expertise in the Context of Laws, Rules, and Guidelines: Fuzzy-Trace Theory’s Alternative Approach to Improve Patient Communication
Authors: Edelson Sarah M. , Reyna Valerie F. 
Published: December 2023

AbstractCurrent guidelines and regulatory frameworks create a dilemma that threatens the effectiveness of much needed communication between patients and medical providers: How can patients be presented with detailed facts without creating cognitive “overload”? We explain how this is a false dichotomy and illustrate, using three examples, how fuzzy-trace theory offers a third way of informing patients.
Photo age: Temporal preferences for external memory across the lifespan
Authors: Soares Julia S. , Finley Jason R. , Roberts Patricia M. 
Published: December 2023

AbstractAutobiographical memories show a temporal pattern with relatively many events recalled from the recent past (recency) and from adolescence to early adulthood (reminiscence bump), and very few events recalled from the first few years of life (childhood amnesia). The current study examined a temporal pattern for external memory – information stored outside of one's brain. Three survey studies asked participants to choose which age(s) in their life they would most want to keep photos from, supposing they had many photos from every year. Participants chose 1 year of photos in Study 1, which sampled undergraduates (N= 499, median age = 19), and in Study 2, which sampled online participants using stratified age brackets (N= 252, age range 18–82). Participants chose 3 years of photos in Study 3, which sampled online participants over 40 using stratified age brackets (N= 240, age range 40–93). Participants’ choices largely showed preferences for time periods likely to be well remembered (recency and the reminiscence bump). Qualitative coding of participants’ reasons for their choices showed common themes, such as positive emotions, connections to other people and pets, life milestones, personal growth, and school. Results suggest that in the case of photos, external memory served to mostly enhance or enrich internal memory and less often to compensate for internal memory.
PREPARATION AND HANDLING OF METHANE FOR RADIOCARBON ANALYSIS AT COLOGNEAMS
Authors: Melchert Jan Olaf , Gwozdz Martina , Gierga Merle , Wacker Lukas , Mücher Dennis , Rethemeyer Janet 
Published: December 2023

ABSTRACTCH4 is the second most important anthropogenic greenhouse gas and originates from different sources. The use of radiocarbon (14C) analysis of CH4 opens up the possibility to differentiate geological and agricultural origin. At the CologneAMS facility, the demand for 14C analysis of CH4 required the development of a sample handling routine and a vacuum system that converts CH4 to CO2 for direct injection of CO2 into the AMS. We evaluated the processing of CH4 using several series of gas mixtures of 14C-free and modern standards as well as biogas with sample sizes ranging from 10 to 50 µg C. The results revealed a CH4 to CO2 conversion efficiency of 94–97% and blank values comparable to blank values achieved with our routinely used vacuum system for processing CO2 samples. The tests with a near modern CH4:CO2 biogas mixture gave reproducible results with a near modern 14C content of 0.967–1.000 F14C, after applying the background correction.
A UNIVERSAL GAS INTERFACE FOR SIMULTANEOUS 14C AND δ13C MEASUREMENTS
Authors: Wertnik Melina , Wacker Lukas , Bernasconi Stefano M. , Haghipour Negar , Eglinton Timothy I , Welte Caroline 
Published: December 2023

ABSTRACTWhile simultaneous radiocarbon and δ13C measurements have been available for organic materials (by accelerator mass spectrometry, AMS, and isotope ratio mass spectrometry, IRMS, respectively), this has not been possible for carbonates until now. Using an existing interface for gas ion source AMS measurements, we developed a prototype for a universal gas interface that allows simultaneous measurement of both carbon isotope ratios from potentially any source of CO2. First results obtained from reference materials (IAEA-C6, OxaII, PhA, IAEA-C1, IAEA-C2, ETH-4) show that for both organic as well as carbonate samples, the precision of radiocarbon measurements in the coupled mode is comparable to routine standalone AMS measurements. For IRMS δ13C measurements, the performance for different materials shows more variation with precisions ranging from 0.07‰ to 0.47‰. However, both organic materials and carbonates can achieve precisions as good as 0.13‰. Once fully automated, the method shows potential for filling the gap of simultaneous carbon isotope measurements for non-organic materials.
Brokers and Finders in Startup Offerings
Authors: Yimfor Emmanuel 
Published: December 2023

Abstract
This study analyzes Form D filings to understand brokered startup offerings. About 60% of brokers are FINRA-registered; the rest, “finders,” are not. Startups with fewer seasoned investors and more local brokers tend to use brokers. Venture capital firms rarely join brokered offerings, but non-accredited investors do, especially offerings with finders. Overall, brokers aid in raising capital. Yet, startups using finders often fail to exit successfully and close following funding. This implies finders might be directing funds from non-accredited investors to lower-quality startups. Brokers help startups raise money without VC support, but the effectiveness of this capital allocation is unclear.