bluuebunny/crossref_metadata_2025_split huggingface dataset:
Emotional and non‐emotional mental imagery and auditory verbal hallucinations (hearing voices): A systematic review of imagery assessment tools
Authors: Janssen Hella , van den Berg Karin C. , Paulik Georgie , Newman‐Taylor Katherine , Taylor Christopher D. J. , Steel Craig , Keijsers Ger P. J. , Marcelis Machteld C. 
Published: October 2023

AbstractIt is unknown to what extent mental imagery and auditory verbal hallucinations (AVHs) are related. Trials evaluating this issue used both emotional and non‐emotional mental imagery tools, thereby complicating outcomes comparisons. Therefore, the present study aimed to systematically review the literature on mental imagery in individuals with AVHs to (1) inventory imagery assessment tools used in this population, (2) to collect information on the relation between emotional and non‐emotional mental imagery in all sensory domains and AVHs and (3) to integrate the outcomes of this systematic review in a model of different mental imagery domains and related assessment tools. We conducted a systematic literature search in the PubMed Database. After full‐text screening, 17 papers were included. Findings showed that a variety of assessment methods have been used to assess various aspects of mental imagery in people with AVHs, suggesting that there is a lack of agreed theoretical conceptualization of mental imagery and AVHs. In addition, the studies confirmed as was expected that non‐emotional mental imagery seemed unrelated to AVHs whereas emotional mental imagery was related to AVHs. Lastly, we proposed a model of mental imagery domains and corresponding assessment methods distinguishing between emotional and non‐emotional mental imagery.
Nanoclusters for photoelectrochemical water splitting: Bridging the photosensitizer and carrier transporter
Authors: Xiao Yonghao , Yao Chuanhao , Su Chenliang , Liu Bin 
Published: October 2023

AbstractIncreasing global environmental deterioration is becoming a serious concern, leading to an exponential increase in scientific interest in renewable energy as an alternative to replace fossil fuels. Photoelectrochemical (PEC) water splitting, which directly converts sunlight into hydrogen fuel, offers a promising renewable energy technology. Semiconductors, used as photoelectrodes, provide the most feasible method for converting solar energy into electrical energy and chemical fuels. Unfortunately, most of the common semiconductors used in PEC water splitting have wide bandgaps, which greatly restrict the utilization efficiency of sunlight. To promote the solar‐to‐hydrogen (STH) efficiency of PEC water splitting, atomically precise clusters with regular crystal structures have been introduced in the PEC systems. In this review, the recent advances in nanoclusters for PEC water splitting, including metal clusters, polyoxometalates, semiconductor clusters, and carbon clusters, are summarized. At last, major challenges and outlook for the development of clusters for PEC water splitting are provided.
Cross‐Linked Pseudopeptides via Pd‐Catalyzed Carbonylative Coupling of α‐Amino Acid Iodides with α‐Amino Acid Esters in the Presence of a CO Surrogate
Authors: Rathod Gajanan K. , Jain Rahul 
Published: October 2023

AbstractWe report the synthesis of cross‐linked pseudopeptides through a palladium‐catalyzed carbonylative cross‐coupling reaction. The reaction involves the coupling of α‐amino acid iodides with α‐amino acid esters via in situ CO insertion to give pseudopeptides linked by the side chain of the electrophilic counterpart. The key features are the use of a sustainable in situ CO surrogate, simple non‐inert conditions, short reaction time, and broad substrate scope. Both amino acids and peptide iodides were utilized as coupling partners.
Improvement of the oxidative stability of instant fried noodles using free and microencapsulated borage (Echium amoenum) and black hollyhock (Altaea rosea var nigra) extracts
Authors: Zamankhani Mahshid , Moeini Sohrab , Mahasti Shotorbani Peyman , MirsaeedGhazi Hossein , Jafarpour Afshin 
Published: October 2023

AbstractThis study investigated the oxidative stability of instant fried noodles by applying free and microencapsulated black hollyhock extracts (BHE) and borage extracts (BE) (BE, BHE, ME‐BE and ME‐BHE). At first, the BE and BHE were encapsulated with whey protein and maltodextrin at a 90:10 ratio through a spray dryer. After evaluating particle characteristics (including anthocyanin content, zeta potential, polydispersity index (PDI), particle size, and morphology), they were added to the noodle formulation (wheat flour 78.5%, NaCl 0.78%, and water 21.21%) at 1% w/w level, and the physicochemical (proximate analysis, pH, color, cooking loss, and texture), sensory properties (taste, odor, color, texture, and overall acceptability), and oxidative stability (acid value, peroxide value, anisidine index, thiobarbituric acid index, conjugated dienes) of the fried noodles were studied. The results showed that the microcapsules had uneven shapes with angular surfaces. There was no significant difference between the zeta potential, particle size, PDI, and encapsulation efficiency of BE‐ and BHE‐loaded microcapsules, and the values reported fell between −34.96 and −34.84 mV, 1.128 and 1.195 μm, 0.247 and 0.283, and 80.08% and 83.47%, respectively. Adding extracts to the functional noodles decreased cooking loss and pH compared to the control. The noodles exhibited a darker color. BE and BHE reduced the oxidation of fried noodle oil, with microencapsulated extracts showing stronger effects during storage (p < .05). Sensory evaluation indicated high acceptability for all samples. Encapsulation effectively preserves the natural antioxidant activities of BE and BHE, providing potential benefits for food processing and storage.
Reducing Gadolinium Contrast With Artificial Intelligence
Authors: Tsui Brian , Calabrese Evan , Zaharchuk Greg , Rauschecker Andreas M. 
Published: October 2023

Gadolinium contrast is an important agent in magnetic resonance imaging (MRI), particularly in neuroimaging where it can help identify blood–brain barrier breakdown from an inflammatory, infectious, or neoplastic process. However, gadolinium contrast has several drawbacks, including nephrogenic systemic fibrosis, gadolinium deposition in the brain and bones, and allergic‐like reactions. As computer hardware and technology continues to evolve, machine learning has become a possible solution for eliminating or reducing the dose of gadolinium contrast. This review summarizes the clinical uses of gadolinium contrast, the risks of gadolinium contrast, and state‐of‐the‐art machine learning methods that have been applied to reduce or eliminate gadolinium contrast administration, as well as their current limitations, with a focus on neuroimaging applications.Evidence Level3Technical EfficacyStage 1
Influence of monsoon extreme rainfall on the distribution of upper tropospheric humidity
Authors: Devika M. V. , Kottayil Ajil , Koovekkallu Prajwal , Xavier Prince , John Viju 
Published: October 2023

AbstractThis study focuses on the changes in the upper tropospheric humidity (UTH) associated with two different extreme precipitation conditions for the period 2000–2019 over the Indian summer monsoon region. The analysis embodies UTH datasets derived from microwave sounders on‐board NOAA and MetOp‐A polar‐orbiting satellites. The circulation characteristics in the upper troposphere are studied using the high‐resolution ERA5 reanalysis data. The analysis of UTH variability over the Indian region shows a unique positive (negative) UTH anomaly patch extending from northwestern regions of India to the northern Arabian Sea for the enhanced (deficient) rainfall days over central India during the southwest monsoon period. The investigation reveals that deep convection alone does not impact the UTH variability. Rather the circulation in the upper troposphere also plays a crucial role in UTH distribution. The dynamics in the upper troposphere cause large‐scale dispersal of both wet and dry air in the upper troposphere, which is linked to the strengthening/weakening of Asian monsoon anticyclone. The study indicates that monsoon extremes exhibit a distinct moisture distribution pattern in the upper troposphere, influenced by upper‐level dynamics, which are associated with the intensity of the Asian monsoon anticyclone.
Rest–grazing before soil thawing alters the below‐ground distribution and extent of rooting in Carex subalpine meadows
Authors: Jing Yuanyuan , Xiao Hong , Xu Changlin , Wang Lin , Chen Yanzhu , Liu Yuanyuan , Yu Xiaojun 
Published: October 2023

AbstractLivestock activities impact plant rhizomes and roots in the topsoil, particularly in the early stages of spring for a Carex subalpine meadow. Rest–grazing during critical periods can prevent harm to these roots and rhizomes caused by livestock, thereby enhancing the ecological performance of grasslands. In accordance with soil thawing and plant re‐greening, we designated five rest–grazing periods during the spring in a Carex subalpine meadows. The findings demonstrate that the topsoil of 0–10 cm, largely consisting of Carex roots, housed over 70% of root volume and root mass. After the plant had regained its greenery for a certain duration, rest–grazing resulted in higher vertical root length distribution index. With earlier rest–grazing, root growth in deeper soil was promoted, consequently transporting more organic material to the deeper soil. Deferred rest–grazing time has the potential to enhance lateral rooting extent, root resistance to vertical uprooting, and root accumulation in topsoil. It follows that increased root accumulation in the topsoil leads to greater loss of soil nutrients and carbon. Consequently, we recommend rest–grazing prior to soil thawing for Carex subalpine meadows, which encourages Carex root growth and fosters greater biomass accumulation in deeper soils. Avoiding “running for the green” and “trampling tillage” has a positive effect on both productivity and long‐term soil nutrients and carbon pool management in pastures.
Fabrication and In Vivo Assessment of Oxidatively Responsive PolyHIPE Scaffolds for Use in Diabetic Orthopedic Applications
Authors: Touchet Tyler J. , Horelica Madeleine , Gruenbaum Rachel , Lewy Keith , Hines Elizabeth , Stranahan Lauren , Saunders W. Brian , Maitland Duncan J. 
Published: October 2023

AbstractAchieving surgical success in orthopedic patients with metabolic disease remains a substantial challenge. Diabetic patients exhibit a unique tissue microenvironment consisting of high levels of reactive oxygen species (ROS), which promotes osteoclastic activity and leads to decreased bone healing. Alternative solutions, such as synthetic grafts, incorporating progenitor cells or growth factors, can be costly and have processing constraints. Previously, the potential for thiol‐methacrylate networks to sequester ROS while possessing tunable mechanical properties and degradation rates has been demonstrated. In this study, the ability to fabricate thiol‐methacrylate interconnected porous scaffolds using emulsion templating to create monoliths with an average porosity of 97.0% is reported. The average pore sizes of the scaffolds range from 27 to 656 µm. The scaffolds can sequester pathologic levels of ROS via hydrogen peroxide consumption and are not impacted by sterilization. Subcutaneous implantation shows no signs of acute toxicity. Finally, in a 6‐week bilateral calvarial defect model in Zucker diabetic fatty rats, ROS scaffolds increase new bone volume by 66% over sham defects. Histologic analysis identifies woven bone infiltration throughout the scaffold and neovascularization. Overall, this study suggests that porous thiol‐methacrylate scaffolds may improve healing for bone grafting applications where high levels of ROS hinder bone growth.
Synthesis and Comparison of Linear Polymannosides for Direct Binding with Escherichia coli
Authors: Hanheiser Natalie , Parshad Badri , Povolotsky Tatyana L. , Khatri Vinod , Achazi Katharina , Bhatia Sumati 
Published: October 2023

AbstractHere, the synthesis of linear polyglycerols bearing multiple copies of mono and dimannosides (LPG40Man0.60 and LPG40(Manα1,2Man)0.60) is demonstrated. A method based on label‐free microscale thermophoresis is optimized to determine the direct binding affinity of multivalent mannosides for Escherichia coli (E. coli) strain ORN178 that produces the fimbriae protein FimH. It is observed that the LPG40(Manα1,2Man)0.60 exhibits only a modest onefold improvement in binding as compared to LPG40Man0.60. Nevertheless, both the multivalent mannosides display remarkably very low nm binding constant (Kd) in contrast to the high µm Kd of the single α‐d‐methylmannoside for intact E. coli ORN178 particles. Furthermore, in an adhesion‐inhibition assay, both multivalent mannosides show 50% inhibition of bacteria adhesion to the HT‐29 colon cells at low µm concentrations.
In silico evaluation of outer membrane protein S2 as a suitable vaccine candidate against Edwardsiella tarda infection of fish
Authors: Disha Somanath , Yathisha Undiganalu Gangadharappa , Harshitha Mave , Maiti Biswajit 
Published: October 2023

Abstract

Objective
Edwardsiella tarda, the agent responsible for edwardsiellosis, is one of the primary emerging pathogens in fish aquaculture. The disease leads to significant economic loss for the farmers. Development of effective vaccines can minimize the disease burden.

Methods
The types of vaccinations that are currently at the center of the most significant research are subunit vaccines. Outer membrane proteins, which are a component of the bacteria, are very well known to be effective at stimulating immune responses in the host. In this study, the gene encoding for outer membrane protein S2 (OmpS2) of E. tarda was identified, cloned, and sequenced, followed by in silico analysis.

Result
The structure and subcellular localization of the protein were first confirmed. Homology modeling of the whole protein was performed, and the protein was checked for its eligibility as a vaccine candidate. This was followed by identifying antigenic sites, B-cell epitopes, and cytotoxic T-lymphocyte epitopes on OmpS2. We obtained a few distinct vaccine peptides from OmpS2. The complete genome of E. tarda was subjected to genome analysis to identify potential epitopes that would bind to the fish major histocompatibility complex molecule and elicit both humoral and cell-mediated immune responses.

Conclusion
This study provides valuable insights for consideration of OmpS2 as a potential vaccine candidate against E. tarda infection.
Evaluating the viability of the use of T-bar and radiotelemetry tags on prespawn Arctic Lampreys
Authors: Spanos Mary C. , Cunningham Curry J. , Drew Katie A. , Sutton Trent M. 
Published: October 2023

Abstract

Objective
Arctic Lampreys Lethenteron camtschaticum are harvested by subsistence and commercial fisheries in the Yukon–Kuskokwim River region of Alaska; however, baseline population data are deficient. For mark–recapture and telemetry studies to be effectively implemented to assess Arctic Lamprey abundance, migratory and dispersal patterns, and spawning locations, tags must not impact fish survival, physiology, or behavior.

Methods
For this laboratory evaluation, we examined survival, tag retention, swim endurance at short-term (1 day posttreatment) and long-term (43 days [~6 weeks] posttreatment) intervals, and incision healing for T-bar-tagged and radio-tagged prespawn Yukon River Arctic Lampreys (N = 216). Six treatment groups were evaluated: control; sham surgery; external T-bar anchor tag; and small (0.30 g; 0.1–0.4% tag burden [ratio of tag weight to fish body weight]), medium (0.57 g; 0.2–0.8% tag burden), and large (1.50 g; 0.6–1.9% tag burden) internal dummy radio transmitter tags.

Result
Although all lampreys survived tagging and surgical procedures through the first 4 weeks of the experiment, a higher tag burden was associated with an increased mortality hazard up to 35 weeks postsurgery. Over the 14-week experimental period, one T-bar tag and one small radio tag were shed by lampreys. Although treatment was not a significant predictor of swim endurance, a higher tag burden led to reductions in swim endurance at 1 day posttreatment but not at 43 days posttreatment. Healing did not differ among surgical treatment groups, but persistent inflammation was observed at incision sites and skin erosion was observed at antenna protrusion locations.

Conclusion
These results indicate that T-bar anchor tags and internal radio tags are acceptable for Arctic Lamprey tagging studies if the radio tag burden is ≤1.3% for short-term (≤14-week) studies and ≤0.5% for long-term (≥14-week) studies.
Advanced porous materials for antimicrobial treatment
Authors: Miguel Sábio Rafael , Corrêa Carvalho Gabriela , Li Jiachen , Chorilli Marlus , Santos Hélder A. 
Published: October 2023

AbstractInfectious diseases are a global public health concern generated by uncontrolled uses of antimicrobials resulting in multidrug‐resistant (MDR) pathogens. The antimicrobial resistance (AMR) has made explicit the ineffective action of the current medicines and vaccines. Rapid diagnosis and effective treatment are the keys to reduce the capacity of MDR pathogens spreading very fast, avoiding high socioeconomic impact, severe and prolonged illness and death. Advanced porous materials have emerged as promising alternatives to the conventional diagnoses and therapy due to their low‐cost production, high biocompatibility, adjustable porous structure, large surface area, easy surface functionalization and capacity of loading high drugs amount. In this review, we first highlighted the current strategies to fight against infectious diseases. Then, we introduce the main advanced porous materials used in infectious diseases, including mesoporous silica nanoparticles (MSNs), porous silicon nanoparticles (PSiNPs), metal–organic frameworks (MOFs), covalent–organic frameworks (COFs), hydrogen‐bonded organic frameworks (HOFs) and porous carbon materials. The strategies to fabricate these materials and their characterization for the application in the recent years for antimicrobial treatment is also discussed. Finally, we present an overview outlook and challenges on the future application of such materials for infectious diseases.
3D morphological changes of the lip and face in patients with cleft lip and alveolus: The comparison of the lip development of incomplete and complete cleft lips under 3 months of age
Authors: Ogimoto Mamiko , Yokota Yusuke , Isomura Emiko Tanaka , Tanaka Susumu , Kogo Mikihiko 
Published: October 2023

AbstractTo treat cleft lip and palate, it is critical to understand the development of the lips and face.ObjectiveThe objective of this study is to comprehend the development of lips and facial features in patients with cleft lip from birth to cheiloplasty. A comparison of incomplete and complete cleft lips was performed.MethodsThe morphology of the lips and face was recorded using a noncontact three‐dimensional morphology recorder from shortly after birth to cheiloplasty. For each patient, their soft tissue growth was analyzed.ResultsThese findings suggest that an incomplete cleft widens the gap between healthy and affected sides from 2 to 3 months of age. The pattern is different from that of a complete cleft.
Site‐specific photo‐crosslinking/cleavage for protein–protein interface identification reveals oligomeric assembly of lysosomal‐associated membrane protein type 2A in mammalian cells
Authors: Terasawa Kazue , Seike Tatsuro , Sakamoto Kensaku , Ohtake Kazumasa , Terada Tohru , Iwata Takanori , Watabe Tetsuro , Yokoyama Shigeyuki , Hara‐Yokoyama Miki 
Published: October 2023

AbstractGenetic code expansion enables site‐specific photo‐crosslinking by introducing photo‐reactive non‐canonical amino acids into proteins at defined positions during translation. This technology is widely used for analyzing protein–protein interactions and is applicable in mammalian cells. However, the identification of the crosslinked region still remains challenging. Here, we developed a new method to identify the crosslinked region by pre‐installing a site‐specific cleavage site, an α‐hydroxy acid (Nε‐allyloxycarbonyl‐α‐hydroxyl‐l‐lysine acid, AllocLys‐OH), into the target protein. Alkaline treatment cleaves the crosslinked complex at the position of the α‐hydroxy acid residue and thus helps to identify which side of the cleavage site, either closer to the N‐terminus or C‐terminus, the crosslinked site is located within the target protein. A series of AllocLys‐OH introductions narrows down the crosslinked region. By applying this method, we identified the crosslinked regions in lysosomal‐associated membrane protein type 2A (LAMP2A), a receptor of chaperone‐mediated autophagy, in mammalian cells. The results suggested that at least two interfaces are involved in the homophilic interaction, which requires a trimeric or higher oligomeric assembly of adjacent LAMP2A molecules. Thus, the combination of site‐specific crosslinking and site‐specific cleavage promises to be useful for revealing binding interfaces and protein complex geometries.
Construction and biological effects of a redox‐enzyme dual‐responsive lufenuron nano‐controlled release formulation
Authors: Liang Qianwei , Hou Chaoqun , Tan Yifei , Wei Nuo , Sun Shaoyang , Zhang Shengfu , Feng Jianguo 
Published: October 2023

AbstractBackgroundPesticide formulations based on nanotechnology can effectively improve the efficiency of pesticide utilization and reduce pesticide residues in the environment. In this study, mesoporous silica nanoparticles containing disulfide bonds were synthesized by the sol–gel method, carboxylated and adsorbed with lufenuron, and grafted with cellulose to obtain a lufenuron‐loaded nano‐controlled release formulation (Luf@MSNs‐ss‐cellulose).ResultsThe structure and properties of Luf@MSNs‐ss‐cellulose were characterized. The results showed that Luf@MSNs‐ss‐cellulose exhibits a regular spherical shape with 12.41% pesticide loading. The highest cumulative release rate (73.46%) of this pesticide‐loaded nanoparticle was observed at 7 days in the environment of glutathione and cellulase, which shows redox‐enzyme dual‐responsive performance. As a result of cellulose grafting, Luf@MSNs‐ss‐cellulose had a small contact angle and high adhesion work on corn leaves, indicating good wetting and adhesion properties. After 14 days of spraying with 20 mg L−1 formulations in the long‐term control efficacy experiment, the mortality of Luf@MSNs‐ss‐cellulose against Ostrinia furnacalis larvae (56.67%) was significantly higher than that of commercial Luf@EW (36.67%). Luf@MSNs‐ss‐cellulose is safer for earthworms and L02 cells.ConclusionThe nano‐controlled release formulation obtained in this study achieved intelligent pesticide delivery in time and space under the environmental stimulation of glutathione and cellulase, providing an effective method for the development of novel pesticide delivery systems. © 2023 Society of Chemical Industry.