bluuebunny/crossref_metadata_2025_split huggingface dataset:
Reporte de caso: Síndrome Hemofagocitico, manifestaciones clínicas y diagnóstico
Authors: Sifuentes Mota Massiel Jane , Matos Pilco Cesia Jemima 
Published: October 2023

El Síndrome hemofagocítico es una inflamación con respuesta inmune ineficaz, excesiva y prolongada. Se caracteriza por fiebre, citopenias, esplenomegalia, hemofagocitosis en médula ósea, hipertrigliceridemia e hipofibrinogenemia resultado de la disfunción de las células natural killer (NK) que lleva a sobreestimulación, proliferación y migración ectópica de células T.
Se describe el caso de un adolescente varón de 13 años de edad natural de Huancavelica, pérdida de peso de seis kilos en tres meses, ictericia, fiebre, hepatoesplenomegalia y pancitopenia. Se obtuvo en el aspirado de médula ósea mostrando grandes cantidades de histiocitos con hemofagocitosis, carga viral para virus Epstein Barrpositivo, debido a contraposición cultural de familiar existió retraso en el diagnóstico etiológico y el tratamiento fue iniciado tardíamente con evolución desfavorable, falla multiorgánica, ingresa a ventilación mecánica, falleciendo a los 28 días de hospitalización.
Características clínicas-epidemiológicas de puérperas SARS-COV-2 positivas y sus recién nacidos, atendidas en el Hospital Nacional Edgardo Rebagliati Martins de marzo a agosto del 2020
Authors: Valencia Vildózola Norma , Solís Mezarino Tania , Cuya Arias Vanessa , Fernández Suárez Sarah 
Published: October 2023

Objetivo: Describir las características clínica- epidemiológicas de las puérperas con pruebas para detección SARS-COV-2 positiva y de sus recién nacidos, que fueron atendidos en el Hospital Edgardo Rebagliati Martins en el periodo de marzo – agosto 2020.
Material y Métodos: Se realizó un estudio descriptivo, retrospectivo y observacional.
Resultados: De 265 mujeres embarazadas con COVID-19 confirmado por RT-PCR o prueba serológica sólo 9.81% fueron sintomáticas. Los síntomas más frecuentes fueron tos y fiebre. La tasa de cesáreas fue de 56.25% y de partos < 37 semanas fue del 18.50%. Se realizó RT- PCR a todos los recién nacidos (268); en 5 (1.87%) el resultado del hisopado fue positivo. 4 fueron asintomáticos, 1 cursó con dificultad respiratoria atribuible a su prematuridad extrema (23 semanas); ninguno falleció. Los hijos de madres sintomáticas tuvieron más probabilidad de requerir hospitalización que los hijos de madres asintomáticas (OR 11; IC 95%: 4.6 – 26.28). La dificultad respiratoria fue el síntoma más frecuente (76.47%) al ingreso de los recién nacidos que requirieron hospitalización y 87.3% de los neonatos no recibió leche materna durante su estancia en el hospital.

Conclusiones: La infección sintomática de SARS-COV-2 materna se asocia a mayor riesgo de morbilidad en su recién nacido. La infección por SARS-COV-2 en el recién nacido es poco probable y cursa por lo general asintomática. En base a estos resultados no se justifica la separación del binomio madre – niño.
Kawasaki completo: Reporte de caso
Authors: Hernandez-Cautter Mariel , Tejada-Hidalgo Katheryne , Morales-Cornejo Luis , Chacaltana- Chavez Stefany 
Published: October 2023

La enfermedad de Kawasaki cumplirá pronto 50 años desde su primera descripción y aún muchos aspectos de esta patología siguen sin comprenderse bien. Un temprano reconocimiento y tratamiento resulta crucial para evitar secuelas cardiológicas irreversibles.
Los casos reportados de la enfermedad de Kawasaki completo en nuestro país son escasos, por lo que nuestro objetivo fue comunicar el primer caso ocurrido en la ciudad de Ica. Es un paciente de sexo masculino de 1 año y 9 meses, que ingresa al Hospital Santa María del Socorro por presentar fiebre persistente de 5 días, labios rojos y agrietados, inyección conjuntival, exantema micropapular en tórax y miembros inferiores, edema y eritema palmo plantar y adenopatía cervical bilateral. Cumplía los criterios de un caso típico de Enfermedad de Kawasaki, fue diagnosticado oportunamente, inició tratamiento con Inmunoglobulina y ácido acetilsalicílico, con evolución favorable.
Hate speech or legitimate satire? Drawing the line in cartoons
Authors: Swain Elizabeth 
Published: October 2023

Controversial cartoons appearing in contemporary news and social media are periodically denounced by consumers for hate speech, and argued over in blogs, reader comments and news articles. Visual and verbal discourse analysts could contribute useful insights to such debates and to awareness raising programmes for addressing hate speech issues in cartoons, but to date have produced little work on the topic. This paper addresses the difficult question of how we distinguish between legitimate satire and hate speech in controversial cartoons about real events featuring public figures belonging to groups with a history of discrimination. The paper proposes that key considerations in this endeavour are the distinction between conceptual and narrative representations and the relevant participant role(s) assigned to the public figure in question (Kress & Van Leeuwen, 2006). The latter’s construal as being, doing or undergoing in the visual structure constrains the options for their evaluation. The evaluations are analysed using visual analogues of the verbal appraisal framework (Martin & White, 2005; Economou, 2009; Swain 2012; White, 2014). It is argued that negative evaluations based on representations of the public figure’s real-life behaviour may more plausibly pass for legitimate satire, whereas those based on the public figure’s appearance alone may be more susceptible to a hate speech interpretation.
Overvågningsregimer i skolen
Authors: Munch Drejer Claus 
Published: October 2023

Denne artikel handler om de forskellige over- vågningsmetoder, som er blevet anvendt i den danske skole fra 1822 til 2010. Artiklen viser de forskellige overvågningsteknikker, som er blevet anvendt, og kæder dem sammen med den viden som overvågningen giver. Det teoretiske grundlag i artiklen hentes hos Michel Foucault og specielt hans værk “Overvågning og straf”, og Foucaults beskrivelse af Jeremy Benthams panoptikon.
Artiklen begynder med at diskutere over- vågningen i den indbyrdes undervisning, som blev indført ved kongeligt påbud i 1822. I den indbyrdes undervisning var eleverne mål for en hierarkisk overvågning, som havde til hensigt at skærpe konkurrencen mellem eleverne. I slutningen af 1800-tallet fokuserede overvågningen på at skabe sunde og disciplinerede elever. Overvågningen fokuserede på hygiejne, efter at undersøgelser viste, at en stor procentdel af de danske elever led af forskel- lige sygdomme. På dette tidspunkt blev over- vågningen også en del af skolearkitekturen. I mellemkrigsårene blev overvågningen indi- vidualiseret, der skulle drages omsorg for den enkelte elev. Der blev indført IQ-test og stand- punktsprøver, og sundheden blev ligeledes et overvågningstema. I 1970’ernes skole blev gruppearbejde en central undervisningstek- nik, og eleverne skulle nu overvåge hinanden i gruppen. Der blev med andre ord etableret en overvågende relation eleverne i mellem. I 1990’erne blev selvovervågning introduceret, og eleverne skulle sammen med læreren overvåge sin egen fremgang. Efter årtusindeskiftet blev overvågningen sat ind i et system som havde til formål at forbedre elevernes færdig- heder i fagene. Overvågningen efter årtusindeskiftet udmærker sig ved at være omfattende, og sat ind i et lineært system, hvor kommunen overvåger skoler, og staten overvåger alle landets skoler og kommuner.

Overvågningsdiskussionen indeholder også en moral, en kritik af humanismen samt en dis- kussion af, hvordan normaliseringen defineres samt disciplineringens virkemidler. Overvågning i skolen er relateret til diskussionen om, hvilke elever samfundet ønsker skal komme ud af skolen. Overvågning er altså medskaber af eleven.
Discovery and biological evaluation of a potent small molecule CRM1 inhibitor for its selective ablation of extranodal NK/T cell lymphoma
Authors: Liu He , Liu Meisuo , Tian Xibao , Wang Haina , Gao Jiujiao , Li Hanrui , Zhao Zhehuan , Liu Yu , Liu Caigang , Chen Xuan , Yang Yongliang 
Published: October 2023

Background:The overactivation of NF-κB signaling is a key hallmark for the pathogenesis of extranodal natural killer/T cell lymphoma (ENKTL), a very aggressive subtype of non-Hodgkin’s lymphoma yet with rather limited control strategies. Previously, we found that the dysregulated exportin-1 (also known as CRM1) is mainly responsible for tumor cells to evade apoptosis and promote tumor-associated pathways such as NF-κB signaling.Methods:Herein we reported the discovery and biological evaluation of a potent small molecule CRM1 inhibitor, LFS-1107. We validated that CRM1 is a major cellular target of LFS-1107 by biolayer interferometry assay (BLI) and the knockdown of CRM1 conferred tumor cells with resistance to LFS-1107.Results:We found that LFS-1107 can strongly suppresses the growth of ENKTL cells at low-range nanomolar concentration yet with minimal effects on human platelets and healthy peripheral blood mononuclear cells. Treatment of ENKTL cells with LFS-1107 resulted in the nuclear retention of IkBα and consequent strong suppression of NF-κB transcriptional activities, NF-κB target genes downregulation and attenuated tumor cell growth and proliferation. Furthermore, LFS-1107 exhibited potent activities when administered to immunodeficient mice engrafted with human ENKTL cells.Conclusions:Therefore, LFS-1107 holds great promise for the treatment of ENKTL and may warrant translation for use in clinical trials.Funding:Yang's laboratory was supported by the National Natural Science Foundation of China (Grant: 81874301), the Fundamental Research Funds for Central University (Grant: DUT22YG122) and the Key Research project of 'be Recruited and be in Command' in Liaoning Province (Personal Target Discovery for Metabolic Diseases).
Evaluation of intracranial physiological calcifications in Computed Tomography
Authors: Bhatt Bhupendra Prasad 
Published: October 2023

Introduction: Intracranial physiological calcifications are not related to any pathological conditions, rather they are due to the normal deposition of calcium or iron in the different parts of the brain. Computed Tomography (CT) scan is superior to all other modalities in terms of sensitivity in the detection of intracranial physiological calcifications. The objective of the study was to evaluate the frequency and location of intracranial physiological calcifications and also study them according to age and gender.
Methods: A prospective cross-sectional study with a purposive sampling technique was conducted from November 2020 to February 2021 at the Department of Radiology and Imaging. CT scan images of every age group were reviewed from the base of the skull to the vertex excluding images with intracranial pathologies, injuries, artifacts, contrast enhancement and the patients with follow-up scans. Data were analyzed using SPSS version 25. Descriptive analysis was primarily preferred accompanied by inferential statistics.
Results: Out of 412 patients, 60.7% were male and the mean age was 41.16 ±19.915 years. The total number of calcifications was 795. 92.8% of patients showed calcifications. Males had a higher number of calcifications. The highest number of calcifications was seen in the age group 20-30. The highest calcification was seen in the pineal gland (76%) followed by the choroid plexus (70.4%) and the lowest in the caudate nucleus (0.38%). The earliest age of calcification was 8 years. There was a significant relationship between the increase in age and the increase in calcification (p<0.05). There was also a significant difference between male and female calcifications (p<0.05).
Conclusion: This study can be useful for clinicians to differentiate normal physiological intracranial calcifications from pathological calcification which will reduce misinterpretation of the calcifications.
The effect of four-week high ıntensity ınterval training on blood oxygen saturation, body composition and some performance parameters in young male football players
Authors: Aslan Tahir Volkan , Kahraman Muhammed Zahit 
Published: October 2023

This study was conducted to determine the effect of four weeks of high intensity interval training on blood oxygen saturation, body composition and some performance parameters in young male football players. Pre-test-post-test control group experimental method was used in the study. Twelve experimental (age: 16,33,77 years; height: 171,50,6,23 cm; body weight: 58,33,5,19 kg) and 12 control (age: 16,50,52 years; height: 168,58,5,68 cm; body weight: 58,05,4,60 kg) male football players aged 15-17 years, who regularly exercise and have been playing football for at least 3 years participated in the study. In the study, the experimental group performed high intensity interval training 3 days a week in addition to football training for 4 weeks. The control group only performed routine football training. In the study, height and body weight, resting heart rate, systolic and diastolic blood pressure, blood oxygen saturation, body composition, 20 m sprint test, Illinois agility test and Yo-Yo interval running test were applied as pre and post tests. The normality level of the data was determined by Shapiro-Wilk test. Independent Sample T Test for independent groups and Paired Sample T Test for dependent groups were used to analyse the normally distributed data. According to the findings of the study, while statistical significance was determined in blood oxygen saturation, body composition, Illinois agility test and Yo-Yo interval running parameters of the experimental group (p<0.05), no significant difference was found in 20 m sprint test (p>0.05). According to the results of the study, it can be said that 4-week high intensity interval training has positive effects on blood oxygen saturation, body composition and performance parameters in young male football players.
An Analysis of the Dawn Vocalisation of a Male Grey Shrikethrush (Colluricincla harmonica)
Authors: Guppy Michael , Fullagar Peter 
Published: October 2023

ABSTRACT
The vocalisations of the Grey Shrikethrush are loud, clear, pleasing to the ear, and a stand-out feature of the bird song in areas in which they occur. However, data on these vocalisations in the literature are sparse, as are any attempts at either quantitative or qualitative analysis. Consequently, almost nothing is known about the character of this very obvious song. We made eight recordings of the dawn song of a male individual at the start of the breeding season on the south-east coast of Australia, in spotted gum forest, 350 km south of Sydney. The song comprised discreet groups of notes which we call syllables. The syllables are sung about every 5-10 seconds, and the individual produced 20 different syllables over the course of the eight recordings. Various analyses revealed that new syllables were added gradually over the recording period, and reached a maximum number at the sixth recording, nine days after the first recording. The frequency of use of particular syllables varied markedly, it was common for some syllables to be used as repeats, particular heterogeneous syllable couplets were commonly used as alternations, and the sequence of syllables could be remarkably similar between different recordings. We suggest a way forward to determine whether these patterns are a common feature of the vocalisations of this species.
Hematological and Coagulation Features of COVID-19 Patients in Hodeidah, Yemen
Authors: Balkam Fuad Ahmed , Al-Kamarany Mohammed Amood 
Published: October 2023

Background: The blood parameters are very important markers for the progression of COVID-19 infection and predicator for severity.
Objectives: Therefore, the study aimed to describe the hematological and coagulation features of coronavirus disease 2019 (COVID-19) infection.
Methodology: The descriptive study (a case series) included 49 patients that were diagnosed clinically and confirmed by the real time – polymerase chain reaction (RT-PCR) with COVID-19. The patients were extremely debilitated, the severe and critical cases were treated in the isolation center (inpatient). Hematological parameters and coagulation tests were measured based on standards methods.
Results: The results revealed that 85.7 % of the patients had pretreatment leukocytosis with average count of WBC 15.24 ± 6.18 (×10 9/L). On the other hand, the WBC count, which had reached a peak of 34 (×10 9/L) as maximum value. Also, the reduction of the lymphocytes (lymphopenia) associated with COVID -19 infection was up to 1 % with average (8.75 ± 6.92 %). The neutrophils increased (neutrophilia) to 98 % with average (87.40±8.45%). In addition, the thrombocytopenia was reported in 2/49 cases (4.08 %), and low in hemoglobin (severe anemia) was reported in 5/49 case (10.20 %). The coagulation tests revealed increased in D-dimer levels (p < 0.05) in severe and critical patients. On the other hand, the results showed normal in prothrombin time (PT) and partial thromboplastin time (PTT) (p > 0.05).
Conclusion: The study concluded that decrease in lymphocytes (lymphopenia), increase in NLR in patients with severe COVID-19 infection and increase in D-dimer are good predicator for progressive and severity illness in COVID-19 infection.
Effect of Silicon and Nutrients on Growth, Flowering and Corm Traits of Gladiolus under Normal Soil Conditions
Authors: Swaroop Kishan , Sindhu K. , Singh Kanwar P. , Sharma V. K. , Bhatia Reeta , Kumar Arun 
Published: October 2023

A field experiment was conducted at the research farm of the Division of Floriculture and Landscaping, ICAR-Indian Agricultural Research Institute, New Delhi, during the year 2021-22 to know the effect of silicon and nutrients on growth, flowering and corm traits of gladiolus under normal soil conditions. The experiment was laid out in randomized block design with twelve treatment combinations and three replications. A gladiolus variety, Pusa Shanti with different levels of nutrients and silica oxide concentrations with soil and foliar applications was accommodated in the experiment. The data for growth, floral, corms traits including physiological characters were collected and compiled, statistically analyzed. The results of experiment indicated that combined application of silicon with soil and foliar spray along with nutrients significantly influenced all the vegetative, flowering and corm characters in gladiolus and treatment T10 (S1F1N1N2) i.e. silica oxide @ 30 kg ha-1 with soil + 1% foliar application, five times (30 DAP),+10 tones ha-1 vermicompost + 200:100:100kg ha-1NPK was the best and recorded plant height(135.00 cm), spike length (110.66 cm), length of rachis (82.33 cm), vase life in normal tap water (17.00 day) and number of corms/cormels per plant (3.66 and 50.33 respectively) followed by treatment T11 (S2F1N1N2) which had recorded the maximum sprouting % and more number of florets per spike and T12, as compared to control treatment. Further results also indicated that treatment T10 (S1F1N1N2) had recorded maximum single corm’s weight 51.66 g, diameter of corm 6.03 cm, dry weight of plant 26.33 g; whereas, treatment T11 had recorded maximum fresh weight of plant 155.66 g, total chlorophyll content (a+b) 2.28 mg/g, membrane stability index 82.40 and relative water content 85.33% as compared to control and remaining treatments.
Quantitative Descriptive Analysis of Comparative Advantages of Fisheries Commodities in Baubau City, Southeast Sulawesi, Indonesia
Authors: Gumilar Iwang , Idrus Waode Velya Leona Putri , Khan Alexander , Maulina Ine 
Published: October 2023

Aims: This research aims to analyze of comparative and competitive advantages and determine center location of fisheries commodities in Baubau City, Southeast Sulawesi, Indonesia.
Study Design: The research was conducted by survey methods.
Place and Duration of Study: Research was conducted in Baubau City, Southeast Sulawesi, three months, starting from July 2023 to September 2023.
Methodology: The data encompasses the commodities' results over a span of seven years (2016 until 2022). Analysis methods used description analysis to determine comparative and competitive advantages of fisheries commodities. Tools analysis used the Location Quotient methods (LQ).
Results: Based on the research conducted, it was found that out of the 27 fish species, the leading fisheries commodity in Baubau City, Southeast Sulawesi, includes Crumenophthalmus sp., Rastrelliger sp., Decapterus sp., Katsuwonus sp., Thunnus sp., Elagatis sp., Coryphaena sp., with the highest catch being Katsuwonus sp., totaling 33,657 tons over the past seven years (2016-2022) and representing the largest catch in Southeast Sulawesi. The results indicate that Skipjack Tuna is the commodity which has comparative and competitive advantages i.e. 37.32 (LQ > 1). Skipjack Tuna production, average 5,816.15 tons per year. Batupoaro District is the center location of Skipjack Tuna in Baubau City. Production of Skipjack Tuna amount 1,375.50 tons per year or 24% from total production in Baubau City.
Conclusion: Skipjack Tuna is the commodity which has comparative and competitive advantages in Baubau City. Batupoaro District is the center location of Skipjack Tuna in Baubau City.
Assembly of Arbitrary Designer Heterostructures with Atomically Clean Interfaces
Authors: Jin Keda , Wichmann Tobias , Wenzel Sabine , Samuely Tomas , Onufriienko Oleksander , Szabó Pavol , Watanabe Kenji , Taniguchi Takashi , Yan Jiaqiang , Tautz F. Stefan , Lüpke Felix , Ternes Markus , Martinez‐Castro Jose 
Published: October 2023

AbstractVan der Waals heterostructures are an excellent platform for studying intriguing interface phenomena, such as moiré and proximity effects. Many of these phenomena occurring in such heterostructures' interfaces and surfaces have so far been hampered because of their high sensitivity to disorder and interface contamination. Here, it reports a dry polymer‐based assembly technique to fabricate arbitrary designer van der Waals heterostructures with atomically clean surfaces. The key features of the suspended dry pick‐up and flip‐over assembly technique are: 1) the heterostructure surface never comes into contact with polymers, 2) the assemble is entirely solvent‐free, 3) it is entirely performed in a glovebox, and 4) it only requires temperatures below 130 °C. By performing ambient atomic force microscopy and atomically‐resolved scanning tunneling microscopy on example heterostructures, it demonstrates the fabrication of air‐sensitive heterostructures with ultra‐clean interfaces and surfaces. It envisions that, due to the avoidance of polymer melting, this technique is potentially compatible with heterostructure assembly under ultra‐high vacuum conditions, which promises ultimate heterostructure quality.