bluuebunny/crossref_metadata_2025_split huggingface dataset:
Non-interventional epidemiological program for investigating the real-life practice of using quetiapine (Seroquel®) in patients with schizophrenia and bipolar affective disorder (EPIDEMICUS)
Authors: Medvedev V. E. , Kuznetsova I. G. 
Published: December 2023

The polymorphism of the clinical manifestations of schizophrenia and bipolar affective disorder (BD), late referral to the doctor, comorbidity with somatic diseases and the use of somatotropic medications by psychiatric patients, as well as the frequent development of adverse events (AEs), require constant analysis and improvement of the methods and means of psychopharmacotherapy.Objective: to study the characteristics of the use of quetiapine (Seroquel®) in real outpatient clinical practice.Material and methods. A patient was enrolled in the program if there was a need to prescribe quetiapine (Seroquel®) or to switch from the current therapy to quetiapine. During the program visit, the doctor filled in an individual registration card with information about patient and therapy. The data were statistically analyzed.Results. Quetiapine is prescribed by practicing psychiatrists in Russia not only according to the official indications, but also for psychopathological disorders of other nosology with similar clinical manifestations, such as dementia, organic and affective (depressive episode, recurrent depressive disorder), as well as psychogenic disorders. Up to 27.3% of physicians consider the effect of quetiapine to be quite sufficient in a mixed affective state within the framework of BD dynamics. Quetiapine is used by physicians to treat patients with varying duration of mental disorder (mean 5.1–13.5 years), severity of current mental state (mean CGI-S score 4.3–4.97) and a wide age range (mean age 34.5–60.8 years). When prescribing quetiapine, physicians note that the drug has antidepressant, anxiolytic, sedative and hypnotic effects, regardless of the type of mental disorder. Quetiapine is mainly prescribed as a monotherapy, either primary or resumed after a break – 815 (64.5%) observations. At the same time, quetiapine is used significantly more frequently as monotherapy for BD (69.4%) and mental illnesses of other origin (64.7%) than for schizophrenia (53.8%; p <0.005).Conclusion. In real clinical practice, quetiapine is perceived by psychiatrists as a highly effective and well-tolerated antipsychotic with a broad spectrum of activity that goes beyond the official indications. The practical experience of physicians in Russia shows that in addition to sedative, antipsychotic, antimanic and antidepressant effects, the drug also has antinegative, procognitive, anxiolytic, antiresistant and mood-stabilizing properties.
Atrial cardiomyopathy in patients with cryptogenic embolic stroke: incidence, instrumental diagnostic features, impact on prognosis
Authors: Chazov S. A. , Mekhryakov S. A. , Kulesh A. A. , Syromyatnikova L. I. , Astanin P. A. 
Published: December 2023

Latent atrial fibrillation (AF), whose substrate is atrial cardiomyopathy (AC), is considered the main potential pathogenetic mechanism of cryptogenic embolic stroke (CES). Early detection of AC allows to intensify the search for AF in such patients.Objective: to compare the characteristics of patients with CES in terms of clinical and anamnestic data, echocardiographic parameters, MRI patterns of infarction foci and disease outcomes depending on the presence of the major markers for AC.Material and methods. We studied 103 patients in the acute phase of CES with a lesion confirmed by MRI data, who were divided into two groups according to the presence (n=17) or absence (n=86) of AC. A comprehensive clinical, laboratory, and instrumental examination was performed and long-term outcomes were assessed. The median follow-up period was 32 months.Results. The incidence of AC in the CES population was 17%; the most common markers were an increase in left atrial volume index and paroxysms of supraventricular tachycardia. Patients with AC-CES were characterised by older age and a two-fold increase in the prevalence of coronary heart disease. Patients with AC-CES were nine times more likely to have a "black artery" symptom on MRI than patients without AC. The predictive accuracy of this clinical pattern was 84%, the sensitivity was 60% and the specificity was 86%. Patients with AC-CES had a significantly higher risk (odds ratio 3.4; 95% confidence interval 1.1–9.9; p=0.023) for a composite outcome that included the development of recurrent ischemic stroke, transient ischemic attack, myocardial infarction or death.Conclusion. AC diagnosed by a combination of echocardiographic and electrocardiographic signs is present in 17% of patients with CES. Patients with AC-CES are characterised by elderly age, the presence of atherosclerosis-associated disease, a specific MRI pattern (the “black artery” symptom) and an unfavourable prognosis during the 2.5-year follow-up period.
The use of inhaled nitric oxide (Tianox device) in patients with moderate cognitive impairment
Authors: Starchina Yu. A. , Grishina D. A. , Sokolov E. A. , Parfenov V. A. 
Published: December 2023

Mild cognitive impairment (MCI) is an intermediate stage between normal cognitive function (CF) and dementia. In the general population of elderly, it is diagnosed in 10–15% of cases; in patients attending outpatient appointments, the frequency of diagnosis is 70%. In our country, there is positive experience with the inhalation of nitric oxide, using a device that synthesizes it from the air, for pulmonary and cardiovascular diseases.Objective: to investigate the use of inhaled nitric oxide (Tianox device) in patients with MCI due to cerebrovascular (CVD) and neurodegenerative diseases (NDD) of the brain.Material and methods. We observed 36 patients (8 men, 28 women, mean age 66±8.9 years, from 50 to 76 years) with MCI that developed on the background of CVD and NDD. In addition to stroke prevention therapy, the patients with MCI received daily inhalation of a nitric oxideenriched air mixture via a Tianox device for 30 minutes. The patients had from 7 to 10 inhalation sessions (the first, experimental – 20 minutes, the following sessions – 30 minutes). Detailed neuropsychological tests were performed at baseline and 3 months after the end of treatment.Results. The therapy was well tolerated and no adverse events occurred. After 3 months, the average score on the Montreal Cognitive Assessment increased from 23.7±3.5 to 25.6±3.9 points (p<0.001), the ability to memorize 12 words – from 7.5±1.8 to 8.7±2.1 words (p<0.05), categorical associations – from 14.8±5.0 to 16.9±4.6 words (p<0.05), the number of words found in the Munsterberg test – from 14.9±5.8 to 18.1±5.8 (p<0.001).The emotional state of the patients improved, the signs of depression decreased according to the Beck Depression Inventory from 13.65±8.5 to 11.4±6.7 points (p<0.05), on the Hospital Anxiety and Depression Scale – from 8.6± 5.0 to 7.3±4.1 points (p<0.05); anxiety decreased on the Hospital Anxiety and Depression Scale – from 7.0±5.0 to 5.4±4.5 points (p<0.05), Insomnia Severity Index – from 11.1±7.9 to 7.8±6.3 points (p<0.05).Conclusion. Good tolerability and a positive effect of inhaled nitric oxide on CF and emotional state of patients with MCI against the background of CVD and NDD were found.
The Role of Self-Compassion on Muslim Students’ Altruistic Behavior during COVID-19 Pandemic
Authors: Dwimahesi Narulita Natasya , Musthofa Wakhid 
Published: December 2023

Large-Scale Social Restrictions in Indonesia during the COVID-19 pandemic caused a lack of social contact, thereby limiting individuals from providing direct assistance to others. Conversely, someone who has self-compassion is indicated to have good altruistic behavior. The present study aims to investigate the correlation between self-compassion and altruistic behavior among students during the Large-Scale Social Restrictions in Indonesia caused by the COVID-19 pandemic. This research employed an incidental sampling technique, with 400 college students. The participants comprised 76 men and 324 women, aged between 18 and 25 years. The study utilized the altruism scale (20 items; = 0.867) and the self-compassion scale (23 items; = 0.892) to measure self-compassion and altruistic behavior, respectively. The Spearman rank correlation technique was employed to test the hypothesis, which resulted in a correlation coefficient of 0.254 with p = 0.001 (p < 0.05). The research findings indicate a positive and significant relationship between self-compassion and altruism among students during the pandemic. Specifically, the higher the level of self-compassion, the higher the altruistic behavior. These results suggest that fostering self-compassion in individuals may lead to greater social benefits, such as encouraging positive social habits. Pembatasan Sosial Berskala Besar di Indonesia pada masa pandemi COVID-19 menyebabkan kurangnya kontak sosial sehingga membatasi individu untuk memberikan bantuan langsung kepada orang lain. Di sisi lain, seseorang yang memiliki self-compassion digambarkan dapat memiliki perilaku altruisme yang baik. Penelitian ini bertujuan untuk mengetahui hubungan antara self-compassion dengan perilaku altruisme pada mahasiswa di masa pandemi COVID-19. Penelitian ini menggunakan insidental sampling dengan responden sejumlah 400 mahasiswa. Instrumen yang digunakan adalah skala altruisme (α= 0,867) dan skala self-compassion (α= 0,892). Uji hipotesis menggunakan teknik korelasi rank spearman menunjukkan koefisien korelasi sebesar 0,254 dengan p = 0,000 (p < 0,05). Hasil penelitian menunjukkan bahwa terdapat hubungan yang positif dan signifikan antara self-compassion dengan perilaku altruisme pada mahasiswa di masa pandemi COVID-19. Semakin tinggi self-compassion maka semakin tinggi pula perilaku altruisme. Implikasi dari penelitian ini adalah individu dapat memiliki kesadaran self-compassion yang baik sehingga dapat bermanfaat lebih luas bagi masyarakat mengenai kebiasaan sosial yang positif.
Peran Keterlibatan Ayah dalam Pengasuhan dengan Konsep Diri Remaja Tunadaksa
Authors: Mutia Fatimah , Andayani Tri Rejeki 
Published: December 2023

One of the problems that often faced by the teenagers with physical disabilities is the negative self-concept. Self-concept is a description of a person affected by the environment. The negative self-concept could lead the teenagers into a higher level of juvenile delinquency. Father, as one of the family members has an important role in shaping self-concept on teenagers. Teenagers with adequate attention of a father would tend to feel loved and worth that could lead them to shape a positive self-concept. The purpose of this quantitative-correlational was to determine the role of father involvement in self-concept of teenagers with physical disabilities. The respondents of this research were teenagers with physical disabilities aged 13 – 19 years old with father in total 53 respondents. Sampling technique used in this research was non-probability by using purposive sampling. The instrument used was Father Involvement Scale (rxx’=0,904) and Self-Concept Scale (rxx’=0,930). Data analysis technique was simple linier regression analysis. The result of study showed that there was significant correlation between father involvement in self-concept of teenagers with physical disabilities (R=0,452, p<0,05). Known the value of R2 was 0,204,. It means values the role father involvement in self-concept of teenagers with physical disabilities is 20,4%. Salah satu permasalahan yang sering dijumpai remaja tunadaksa adalah konsep diri negatif. Konsep diri merupakan gambaran mengenai dirinya sendiri yang dipengaruhi oleh lingkungan. Konsep diri negatif dapat membawa remaja pada tingkat kenakalan yang tinggi. Ayah merupakan salah satu anggota dari keluarga yang berperan dalam membentuk konsep diri remaja. Remaja yang mendapat perhatian dari ayahnya akan merasa disayang, berharga, dan mendorong remaja membentuk konsep diri positif. Penelitian kuantitatif-korelasional ini bertujuan untuk mengetahui peran keterlibatan ayah dalam pengasuhan dengan konsep diri remaja tunadaksa. Responden dalam penelitian ini remaja tunadaksa berusia 13-19 tahun yang memiliki ayah dengan jumlah 53 responden. Teknik pengambilan sampel pada penelitian ini adalah non-probability dengan menggunakan purposive sampling. Instrumen yang digunakan dalam penelitian ini adalah Skala Keterlibatan Ayah dalam Pengasuhan (rxx’=0,904) dan Skala Konsep Diri (rxx’=0,930). Teknik analisis data dalam penelitian ini adalah analisis regresi linier sederhana. Hasil dari penelitian ini menunjukkan adanya hubungan signifikan antara keterlibatan ayah dalam pengasuhan dengan konsep diri remaja tunadaksa (R= 0,452, p< 0,05). Diketahui nilai R2 (R Square) sebesar 0,204, artinya nilai peran keterlibatan ayah dalam pengasuhan terhadap konsep diri remaja tunadaksa adalah 20,4%.
VARIABLE DNA SEQUENCE OF THE pMGA GENE IN Mycoplasma gallisepticum
Authors: MILOŠEVIČ BERLIČ Tamara , BENČINA D. , DOVČ P. 
Published: December 2023

Specific fragments of Mycoplasma gallisepticum genomic DNA, representing different regions of pMGA1.1 and pMGA1.2 genes, were amplified by Polymerase Chain Reaction (PCR). Using sequence analysis of pMGA terminal domains, differences in nucleotide sequences among strains of M. gallisepticum were identified. Restriction analysis revealed polymorphism at the 5? -end of the pMGA coding region. By means of sequence analysis it was established that the most variable part of pMGA sequence was the 5? -end of the pMGA gene, the region coding amino-terminal part of pMGA protein, while the 3? -end of the gene was conserved among various M. gallisepticum strains analysed. In some strains insertions or deletions were found that indicate the diversity of the pMGA gene family and might be related to the variable expression of the pMGA gene family. Changes in nucleotide sequences of the pMGA genes were also found within isogenic lineages. Genotypic variability is also confirmed by results of the study of the gene product expression.
Izboljšanje odbire čebel na proizvodne lastnosti z uporabo selekcijskega indeksa
Authors: POKLUKAR Janez 
Published: December 2023

Izdelali smo selekcijski indeks za istočasno odbiro čebel na pridelek medu, nerojivost in na mirnost čebeljih družin. V analizi smo upoštevali populacijo 2.494 matic, zrejenih pri 18 zrejevalcih matic, proizvodno testiranih v 199 čebelarstvih v času 1994 - 1998. Heritabilnost proizvodnje medu je bila 0,41 ± 0,22, h2 nerojivosti čebel 0,73 ± 0,28, h2 mirnosti 0,49 ± 0,24. Indeks = 0,42 * (kg medu na leto) + 1,94 * (točke ocene nerojivosti čebel) + 0,80 * (točke mirnosti čebel). Varianca indeksa je 29,45, varianca agregatnega genotipa pa 62,39. R2 indeksa je 0,47, kar je za 14,5 % več od vrednosti heritabilitete za proizvodnjo medu.
Ocene parametrov disperzije z modelom živali za dnevne meritve pri slovenski črno beli pasmi
Authors: POTOČNIK Klemen , KOVAČ Milena , POGAČAR Janez 
Published: December 2023

V raziskavi smo uporabili podatke o 643 357 meritvah dnevnih meritev za količino mleka in vsebnosti beljakovin ter maščob pri 29 150 kravah slovenske črno bele pasme. V datoteko sorodstva smo dodali še 12 173 živali. Meritve so bile opravljene od marca 1986 do julija 1998. Model je vključeval sezono telitve, starost ob telitvi in stadij laktacije kot sistematske vplive ter naključne vplive črede, stalnega okolja in živali. Vpliv črede je pojasnil skoraj četrtino celotne variabilnosti za količino mleka in malo manj kot desetino za obe lastnosti vsebnosti. Delež variance za vpliv čreda je za količino mleka 0,23, za vsebnost maščobe 0,06 in za vsebnost beljakovin 0,09. Podoben vpliv ima za vse tri lastnosti stalno okolje, saj delež variance znaša za količino mleka 0,23, za vsebnost maščobe 0,07 in za vsebnost beljakovin 0,11. Dednostni delež za količino mleka je 0,20, za vsebnost maščobe 0,22 in za vsebnost beljakovin 0,25. Z uporabo tega modela v praksi bi že mlajšim živalim z manjšim številom meritev ali celo brez njih napovedali plemenske vrednosti. S tem bi skrajšali generacijski interval. Ob uvedbi tega modela v praksi je primerno preveriti ekonomske teže in proučiti korelacije med opazovanimi lastnostmi.
Mapping of contents in "Zbornik Biotehniške fakultete Univerze v Ljubljani. Kmetijstvo. Zootehnika" (Research Reports Biotechnical Faculty University of Ljubljana. Agriculture. Zootechny): an analysis of narrower and broader subject areas
Authors: BARTOL Tomaž 
Published: December 2023

A bibliometric analysis of volumes 74 (1999) and 76 (2000) (altogether 48 articles) of Zbornik Biotehniške fakultete Univerze v Ljubljani. Kmetijstvo. Zootehnika (Research Reports Biotechnical Faculty University of Ljubljana. Agriculture. Zootechny) was based on the Agrovoc descriptors (de) assigned by an indexer (ENI), computer assigned DE (ENC) and category codes (CC) assigned as indexing terms to the respective articles in the Agris database. Two subject indexes based on ENI and ENC coupled together, and on CC were constructed as a material for further analysis. The scatter of indexing terms was then compared with some scientometric laws such as those by Bradford, Zipf, and others. Among 357 different DE (ENI and ENC coupled together in one file) some 80 % were assigned only once or twice. 210 DE occured only once. Organism DE maintained the highest frequency (bacteria: 16 times, followed by useful animals: 13 times). Some 20 % of all different DE were assigned to half of the articles. Among ENI 154 of 221 terms occured only once. Aspect DE possessed the highest frequency among ENI (chemical composition: 11 times, followed by proximate composition: 10 times). Some indexing characteristics were further highlighted such as the use of synonyms and related terms. The results of macroindexing with CC were interpreted with some limitations as there are in classification schemes no sufficient macrocategories referring to microbiology or biotechnology of microorganisms. All of the records of the Slovenian Agris output were processed by one indexer thus maintaining a relatively high indexing consistency what facilitates better information retrieval.
Dokazovanje protiteles proti patogenim mikroorganizmom v tekočinah kokošjega zarodka
Authors: HERMAN Darja , NARAT Mojca , BENČINA Dušan 
Published: December 2023

Pred patogenimi mikroorganizmi, ki se prenašajo prek valilnih jajc, kokošji zarodek ščitijo protitelesa matere v rumenjaku in beljaku. Z uporabo imunoencimskih testov in monoklonskih protiteles (mAb) proti kokošjim imunoglobulinom razredov G (IgG), IgA in IgM smo ugotavljali prisotnost specifičnih protiteles proti Mycoplasma synoviae, M. gallisepticum, Ornithobacterium rhinotracheale in virusu atipične kokošje kuge v alantoisni tekočini (ALT), amnionski tekočini (AMT), žolču in krvi kokošjih zarodkov na različnih stopnjah embrionalnega razvoja. Že 7. dan embrionalnega razvoja je večina zarodkov imela v ALT specifična protitelesa IgG proti M. synoviae, nekateri zarodki pa tudi protitelesa IgG proti M. gallisepticum in virusu atipične kokošje kuge. V ALT so bila pri nekaterih zarodkih prisotna tudi protitelesa razreda IgA in IgM. Protitelesa IgA in IgM so se najverjetneje prenesla iz beljaka v ALT. V AMT smo specifična protitelesa IgG proti M. synoviae dokazali 7. dan embrionalnega razvoja. Količina IgA, IgG in IgM v AMT se je močno povečala po 12. dnevu embrionalnega razvoja. Specifična protitelesa lahko pridejo tudi v žolč, kjer smo protitelesa IgA in IgG proti M. synoviae in O. rhinotracheale dokazali pri 13 dni starih zarodkih. Tudi v vzorcih krvi, vzetih iz alantoisnega krvnega obtoka od 13. do 16. dne embrionalnega razvoja, smo dokazali IgG in IgA.
Ocenjevanje energijske vrednosti mrve
Authors: BABNIK Drago , VERBIČ Jože , ŽNIDARŠIČ Tomaž 
Published: December 2023

Z in vitro metodo, ki temelji na plinu razvijajočem se pri inkubaciji vzorcev z vampnim sokom, smo ocenili vsebnost neto energije za laktacijo (NEL) 100 vzorcem mrve zbranimi v letih 1999 in 2000. Vrednosti smo primerjali z ocenami, pridobljenimi z običajnimi postopki ocenjevanja NEL v slovenskih laboratorijih, to je na podlagi kemične sestave ter prebavljivostnih koeficientov iz preglednic ali ob pomoči regresijskih enačb iz literature. Ugotovili smo, da so na podlagi preglednic DLG (1982) ocenjene vsebnosti NEL v mrvi odstopale od in vitro ocenjenih vrednosti za –0,22±0,35 MJ NEL kg–1 sušine (SS). Ocene na podlagi novejših DLG (1991) preglednic so odstopale od in vitro ocenjenih vrednosti za 0,25±0,31 MJ, na podlagi DLG (1997) za 0,20±0,33 MJ ter na podlagi enačb GfE (1998) za 0,16±0,33 MJ NEL kg–1 SS. Ocene z enačbo po Stekarjevi in sod. (1994) so v povprečju odstopale od in vitro ocenjenih vrednosti za 0,01±0,33 MJ NEL kg–1 SS. Regresijska analiza je pokazala, da so vse ocene sistematično odstopale od in vitro ocenjenih vrednosti. Za ocenjevanje manj kakovostnih vzorcev mrve z ekstenzivnih travnikov, ki vsebujejo manj kot 5,2 MJ NEL kg–1 sušine, priporočamo uporabo starejših nemških preglednic (DLG, 1982), za bolj kakovostne vzorce mrve (> 5,2 MJ NEL) pa so primernejše novejše preglednice (DLG, 1997) in uradne nemške enačbe (GfE, 1998). Povprečni vzorci s slovenskih kmetij so ocenjeni najbolj točno z enačbo po Stekarjevi in sod. (1994). Za vse ocene so bila značilna razmeroma velika povprečna posamična odstopanja (0,27–0,32 MJ kg–1 SS) od in vitro ocenjenih vrednosti. Največja posamična odstopanja so presegla 1 MJ kg–1 SS. Predlagali smo nove enačbe za ocenjevanje vsebnosti presnovljive energije in NEL v mrvi. Ugotovili smo, da je mogoče s temi enačbami odstopanja od in vitro ocenjenih vrednosti zmanjšati za 10 do 50 %. Nepojasnjenim odstopanjem, ki znašajo v povprečju približno 0,2 MJ NEL kg–1 SS, se z uporabo klasične weendske analize ne moremo izogniti.
Vsebnost dušika, vezanega na v kislem detergentu netopna vlakna, v krmi s travinja
Authors: VERBIČ Jože , BABNIK Drago , RESNIK Mojca 
Published: December 2023

Proučevali smo povezave med deležem v kislem detergentu netopnega dušika (KDNN, v g kg –1 skupnega N) na eni strani ter vsebnostma surovih beljakovin (SB) in surove vlaknine (SVl) na drugi. Ugotovili smo, da se v krmi s travinja s povečevanjem vsebnosti SB delež KDNN zmanjšuje, medtem ko se s povečevanjem vsebnosti SVl povečuje. Pri dani vsebnosti surovih beljakovin je bil pri metuljnicah delež KDNN večji kot pri travah. Delež KDNN v senu z ekstenzivnih travnikov je bil večji kot pri senu z intenzivnih travnikov. Pri silažah prve košnje smo pri dani vsebnosti SB opazili tendenco manjšega deleža KDNN kot pri silažah iz naslednjih košenj. Izračunali smo enačbe, ki omogočajo napovedovanje deleža KDNN v vzorcih zelene krme, sena in silaž na podlagi vsebnosti SB, in ugotovili, da omogočajo grobo oceno. Zaenkrat lahko dobimo točno vsebnost KDNN le s kemijsko analizo.