bluuebunny/crossref_metadata_2025_split huggingface dataset:
Randomized Comparison of Electronic Health Record Alert Types in Eliciting Responses about Prognosis in Gynecologic Oncology Patients
Authors: Musser Robert Clayton , Senior Rashaud , Havrilesky Laura J. , Buuck Jordan , Casarett David J. , Ibrahim Salam , Davidson Brittany A. 
Published: January 2024

Objectives To compare the ability of different electronic health record alert types to elicit responses from users caring for cancer patients benefiting from goals of care (GOC) conversations.
Methods A validated question asking if the user would be surprised by the patient's 6-month mortality was built as an Epic BestPractice Advisory (BPA) alert in three versions—(1) Required on Open chart (pop-up BPA), (2) Required on Close chart (navigator BPA), and (3) Optional Persistent (Storyboard BPA)—randomized using patient medical record number. Meaningful responses were defined as “Yes” or “No,” rather than deferral. Data were extracted over 6 months.
Results Alerts appeared for 685 patients during 1,786 outpatient encounters. Measuring encounters where a meaningful response was elicited, rates were highest for Required on Open (94.8% of encounters), compared with Required on Close (90.1%) and Optional Persistent (19.7%) (p < 0.001). Measuring individual alerts to which responses were given, they were most likely meaningful with Optional Persistent (98.3% of responses) and least likely with Required on Open (68.0%) (p < 0.001). Responses of “No,” suggesting poor prognosis and prompting GOC, were more likely with Optional Persistent (13.6%) and Required on Open (10.3%) than with Required on Close (7.0%) (p = 0.028).
Conclusion Required alerts had response rates almost five times higher than optional alerts. Timing of alerts affects rates of meaningful responses and possibly the response itself. The alert with the most meaningful responses was also associated with the most interruptions and deferral responses. Considering tradeoffs in these metrics is important in designing clinical decision support to maximize success.
Development of the Integrated Computer Simulation Model of the Intracellular, Transmembrane, and Extracellular Domain of Platelet Integrin αIIbβ3 (Platelet Membrane Glycoprotein: GPIIb–IIIa)
Authors: Nakayama Masamitsu , Goto Shinichi , Goto Shinya 
Published: January 2024

Background The structure and functions of the extracellular domain of platelet integrin αIIbβ3 (platelet membrane glycoprotein: GPIIb–IIIa) change substantially upon platelet activation. However, the stability of the integrated model of extracellular/transmembrane/intracellular domains of integrin αIIbβ3 with the inactive state of the extracellular domain has not been clarified.
Methods The integrated model of integrin αIIbβ3 was developed by combining the extracellular domain adopted from the crystal structure and the transmembrane and intracellular domain obtained by Nuclear Magnetic Resonace (NMR). The transmembrane domain was settled into the phosphatidylcholine (2-oleoyl-1-palmitoyl-sn-glycerol-3-phosphocholine (POPC)) lipid bilayer model. The position coordinates and velocity vectors of all atoms and water molecules around them were calculated by molecular dynamic (MD) simulation with the use of Chemistry at Harvard Macromolecular Mechanics force field in every 2 × 10−15 seconds.
Results The root-mean-square deviations (RMSDs) of atoms constructing the integrated αIIbβ3 model apparently stabilized at approximately 23 Å after 200 ns of calculation. However, minor fluctuation persisted during the entire calculation period of 650 ns. The RMSDs of both αIIb and β3 showed similar trends before 200 ns. The RMSD of β3 apparently stabilized approximately at 15 Å at 400 ns with persisting minor fluctuation afterward, while the structural fluctuation in αIIb persisted throughout the 650 ns calculation period.
Conclusion In conclusion, the integrated model of the intracellular, transmembrane, and extracellular domain of integrin αIIbβ3 suggested persisting fluctuation even after convergence of MD calculation.
Palladium-Catalyzed Carbothiolation by Using Thioesters with Formation of a Quaternary Carbon
Authors: Nakada Masahisa , Okura Yoshifumi , Ito Ryunosuke , Kumazawa Hyu 
Published: January 2024

AbstractA Pd-catalyzed carbothiolation using thioesters, with the formation of a quaternary carbon, is described. Carbothiolation using thioesters was problematic due to a direct-coupling side reaction that produced a sulfide, but this side reaction was successfully suppressed by an appropriate selection of the thioester and the reaction conditions. In the preparation of chroman or coumaran derivatives by this method, the reaction using S-phenyl 4-methoxybenzenecarbothioate Pd(PPh3)4, and Cs2CO3 at 100 °C in toluene afforded the desired products in good yields (77–92%). The carbothiolation reaction also proceeded with esters of alkanethiols in higher yields (56–93%) than those obtained from the previously reported carbothiolation using triisopropylsilyl (TIPS) thioethers (12–63%). The developed Pd-catalyzed carbothiolation is applicable in the preparation of a wide range of products, including a tetralin derivative and an indoline derivative. The Pd-catalyzed carbothiolation using thioesters was found to be comparable with a previously reported carbothiolation using TIPS thioethers in terms of the yield and substrate scope, and to be a superior alternative owing to the stability and lower cost of thioesters.
Radiomics-Based Machine Learning Classification Strategy for Characterization of Hepatocellular Carcinoma on Contrast-Enhanced Ultrasound in High-Risk Patients with LI-RADS Category M Nodules
Authors: Li Lingling , Liang Xiaoxin , Yu Yiwen , Mao Rushuang , Han Jing , Peng Chuan , Zhou Jianhua 
Published: January 2024

Abstract
Objective Accurate differentiation within the LI-RADS category M (LR-M) between hepatocellular carcinoma (HCC) and non-HCC malignancies (mainly intrahepatic cholangiocarcinoma [CCA] and combined hepatocellular and cholangiocarcinoma [cHCC-CCA]) is an area of active investigation. We aimed to use radiomics-based machine learning classification strategy for differentiating HCC from CCA and cHCC-CCA on contrast-enhanced ultrasound (CEUS) images in high-risk patients with LR-M nodules.
Methods A total of 159 high-risk patients with LR-M nodules (69 HCC and 90 CCA/cHCC-CCA) who underwent CEUS within 1 month before pathologic confirmation from January 2006 to December 2019 were retrospectively included (111 patients for training set and 48 for test set). The training set was used to build models, while the test set was used to compare models. For each observation, six CEUS images captured at predetermined time points (T1, peak enhancement after contrast injection; T2, 30 seconds; T3, 45 seconds; T4, 60 seconds; T5, 1–2 minutes; and T6, 2–3 minutes) were collected for tumor segmentation and selection of radiomics features, which included seven types of features: first-order statistics, shape (2D), gray-level co-occurrence matrix, gray-level size zone matrix, gray-level run length matrix, neighboring gray tone difference matrix, and gray-level dependence matrix. Clinical data and key radiomics features were employed to develop the clinical model, radiomics signature (RS), and combined RS-clinical (RS-C) model. The RS and RS-C model were built using the machine learning framework. The diagnostic performance of these three models was calculated and compared.
Results Alpha-fetoprotein (AFP), CA19-9, enhancement pattern, and time of washout were included as independent factors for clinical model (all p < 0.05). Both the RS and RS-C model performed better than the clinical model in the test set (area under the curve [AUC] of 0.698 [0.571–0.812] for clinical model, 0.903 [0.830–0.970] for RS, and 0.912 [0.838–0.977] for the RS-C model; both p < 0.05).
Conclusions Radiomics-based machine learning classifiers may be competent for differentiating HCC from CCA and cHCC-CCA in high-risk patients with LR-M nodules.
A Pair of Compound Heterozygous IARS2 Variants Manifesting West Syndrome and Electrolyte Disorders in a Chinese Patient
Authors: Zhou Feiyu , Yi Gui , Liu Xiangyu , Sheng Wenchao , Shu Jianbo , Li Dong , Cai Chunquan 
Published: January 2024

Abstract
Background Aminoacyl-tRNA synthetases (ARSs) are evolutionarily conserved enzymes that ensure the accuracy of the translation process. Isoleucyl-tRNA synthetase 2 (IARS2) gene is a type of ARS that encodes mitochondrial isoleucine-tRNA synthetase. Pathogenic variants in the IARS2 gene are associated with mitochondrial disease which involves several patients presenting broad clinical phenotypes. These clinical phenotypes include West syndrome, Leigh syndrome, and Cataract, growth hormone deficiency, sensory neuropathy, sensorineural hearing loss, and skeletal dysplasia syndrome. Only 29 cases have been reported worldwide. The patient manifested recurrent convulsions, and specific clinical manifestations included electrolyte disorders and recurrent infections.
Methods Whole-exome sequencing was performed on the child with West syndrome. Three-dimensional structure reconstruction and thermodynamic stability prediction were performed to further analyze the relationship between variation and phenotype.
Conclusion This study further expands the clinical spectrum of IARS2 pathogenic variants. The case summaries help raise clinical awareness of IARS2-associated disease and reduce misdiagnosis.
Result In this report, a 13-month-old girl was diagnosed with West syndrome and Leigh syndrome for 7 months. Compound heterozygous variants in the IARS2 gene (NM_018060.4), c.2450G>A (Arg817His) and copy number variation (NC_000001. 11: g. (220267549_220284289) del), were detected by WES. This study further expands the clinical spectrum of IARS2 pathogenic variants. The case summaries help raise clinical awareness of IARS2-associated disease and reduce misdiagnosis.
Wavelength-scanning pixel-super-resolved lens-free on-chip quantitative phase microscopy with a color image sensor
Authors: Wu Xuejuan , Sun Jiasong , Chen Yang , Wei Jiahao , Chen Qian , Poon Ting-Chung , Gao Peng , Zuo Chao 
Published: January 2024

We report a wavelength-scanning-based lens-free on-chip microscope using a color CMOS sensor and a matching modified phase retrieval algorithm for pixel super-resolution. Compared to traditional monochrome industrial cameras, color sensors favored by the consumer electronics industry have smaller pixel sizes, higher performance, and lower costs. However, the color filtering array (CFA) introduces inherent modulation to the holograms acquired under quasi-monochromatic illumination, which complicates the data processing in lens-free on-chip microscopy. Without physically removing the CFA positioned on the sensor chip, we demonstrate quantitative phase imaging (QPI) with a lateral half-width resolution of 615 nm over a wide field-of-view of 51.88 mm2 by exploiting the green-channel data from Bayer-masked holograms. The resulting spatial bandwidth product is 137.2 megapixels, over 10 times that of a conventional optical microscope. The rationale for using only green-channel data is that the information from each sampling point is not lost during propagation but rather distributed to all pixels in the image. Therefore, the missing data in other channels can be recovered by exploiting the sufficient differences among the raw images captured at different wavelengths. Compared to the scheme with monochrome sensors, this method requires the acquisition of several more images to guarantee the convergence of the algorithm. Experimental results show that we can achieve high-quality QPI performance, thus demonstrating the applicability of cost-effective color sensors in the field of lens-free holographic microscopy.
V-line 2-tensor tomography in the plane
Authors: Ambartsoumian Gaik , Mishra Rohit Kumar , Zamindar Indrani 
Published: January 2024

Abstract
In this article, we introduce and study various V-line transforms (VLTs) defined on symmetric 2-tensor fields in

R

2

. The operators of interest include the longitudinal, transverse, and mixed VLTs, their integral moments, and the star transform. With the exception of the star transform, all these operators are natural generalizations to the broken-ray trajectories of the corresponding well-studied concepts defined for straight-line paths of integration. We characterize the kernels of the VLTs and derive exact formulas for reconstruction of tensor fields from various combinations of these transforms. The star transform on tensor fields is an extension of the corresponding concepts that have been previously studied on vector fields and scalar fields (functions). We describe all injective configurations of the star transform on symmetric 2-tensor fields and derive an exact, closed-form inversion formula for that operator.
Temperature measurement of molten glass under batch feeding process by means of electrical resistance tomography
Authors: Kawaguchi Tatsuya , Saito Takushi 
Published: January 2024

Abstract
Electrical Resistance Tomography stands out as a powerful tool applicable to opaque environments, particularly in scenarios involving highly contaminated flows, gas–liquid two-phase flows with elevated void fractions, and electrically-conductive fields. The semi-conductive nature of high-temperature molten glass renders resistance tomography suitable for determining temperature distributions within such optically opaque mediums. This study aims to extend the application of the tomography technique to the spatial measurement of temperature in high-temperature molten glass. In order to verify the effectiveness of the developed system, a preliminary test was conducted by using an electrolyte solution in water to explore the overall system capabilities. Following the confirmation of the effective resolution of the proposed system, the measurement apparatus was employed for the actual temperature measurement of molten glass. The developed equipment featured sixteen independent electrodes, a low-impedance multiplexer, amplifier, rectifier, and a oscillating signal generator. Electrical potentials of the electrodes were recorded using a high-impedance amplifier as well as a data logging system. Upon collecting the electrical potential dataset, reconstruction computations were executed using the software. The measurement results show that the developed measurement system facilitates the acquisition of quantitative temperature distributions, as evidenced by the injection of a batch of low-temperature glass beads.
Electron cyclotron resonance (ECR) enhanced diverging magnetic field for controlled particle flux in a microwave-excited plasma column – a numerical investigation
Authors: Ojha Anupama , Suvansh Shubhankur , Pandey Himanshu , Pandey Shail 
Published: January 2024

Abstract
The present work is an investigation of the effect of an externally applied diverging magnetic field on a surface microwave-sustained plasma column. Microwaves (2.45 GHz) are allowed to propagate through a tapered waveguide system containing a discharge tube made up of quartz. Argon gas flows down the tube from top to bottom maintaining a pressure of 1 Torr and a plasma is ignited within the tube owing to the surface microwave propagation. In the absence of a magnetic field, the plasma column exhibits discrete regions of overdense plasma near its center where the electric field of the incident microwaves is observed to be high. As the gas flows down the tube, the plasma density is also found to decrease and the resulting plasma profile is asymmetric about its length. However, in the presence of an axially applied diverging magnetic field , an axial force acts on the plasma, and the discrete overdense plasma regions are found to get symmetrically arranged along the plasma axis. Interesting results are observed when the diverging magnetic field includes a region of electron cyclotron resonance (ECR) corresponding to the microwave frequency. In the presence of an ECR, the electrons are expected to experience resonant heating by microwaves other than the direct heating by these waves. Under such conditions, the discharge dynamics are governed by the resonance mechanism, and the bright spots of overdense plasma regions get shifted to the ECR positions. As the magnetic field strength increases, the overdense plasma moves axially away from the center. These results are a clear indication of a magnetically controlled particle flux over a target and can be exploited in various material processing applications, particularly for surface cleaning applications in the semiconductor industries.
Applying exponential unit for breaking symmetry of memristive maps
Authors: Phu Thoai Vo , Volos Christos , Vincenzo Radogna Antonio , Pham Viet-Thanh , Grassi Giuseppe , Momani Shaher 
Published: January 2024

Abstract
The emergence of memristors has piqued significant interest in memristive maps due to their unique characteristics. In this paper, we introduce a novel and effective method for constructing memristor maps, leveraging the power of exponential units. Interestingly, the incorporation of these exponential units disrupts symmetry and alters the count of fixed points within the map. The method is simple to build maps with chaos and higher order maps. These make our work different from existing methods. To demonstrate the efficacy of our approach, we have focused our attention on examining the dynamics, feasibility, and practical applications of a specific map, referred to as the EPMM1 map. Furthermore, we show that by extending this approach, it becomes straightforward to create other innovative memristive maps, including those with multiple memristors.
Dynamical features and traveling wave structures of the perturbed Fokas-Lenells equation in nonlinear optical fibers
Authors: Muhammad Shah , Abbas Naseem , Hussain Akhtar , Az-Zo’bi Emad 
Published: January 2024

Abstract
In this study, the new complex wave solutions of the perturbed Fokas-Lenells (p-FL) equation, which has applications in nonlinear optical fibers are obtained using a new extended direct algebraic method. This model represents recent electronic communications like Internet blogs, facebook communication and twitter comments. The obtained solutions are the different classes of traveling wave structures with singular solutions Type-I & II, dark-singular, dark, and dark-bright solutions. Furthermore, stability conditions for the computed structures are reported. Also, graphical representations of some particular structures are shown by taking the specific values of the constants. The ordinary differential equation (ODE) obtained from a traveling wave transformation is converted into a dynamical system using Galilean transformation. The phase plane analysis is done for different values of the controlled parameters d
1 and d
3. A perturbation term is added to analyze the chaotic dynamics, and plots indicate that the system shows the chaotic dynamics. Also, sensitivity analysis shows that the system is sensitive to initial conditions. The conclusion is accounted for toward the end.
Light propagation in the vicinity of the ModMax black hole
Authors: Guzman-Herrera E. , Breton N. 
Published: January 2024

Abstract
ModMax is a nonlinear electrodynamics theory with the same symmetries as Maxwell electrodynamics. Static spherically symmetric solutions have been derived by coupling ModMax electrodynamics with the Einstein equations, which can represent a black hole. In this paper, we analyze light propagation in the vicinity of the ModMax black hole. We determine birefringence, light trajectories, deflection, redshifts, as well as the shadow of the black hole using the effective or optical metric to determine the optical paths of light; comparison is done with the corresponding effects in the neighborhood of the Reissner-Nordstrom black hole, that is the solution to the Einstein-Maxwell equations.
Dynamic laser speckle study on the effect of TiO2 and SiO2 nanoparticles in coatings
Authors: Balamurugan R , Arul A R , Ramalingam H B , Venckatesh R 
Published: January 2024

Abstract
The coatings of TiO2 and SiO2 nanoparticles mixed with latex paint on the sample are studied. The sample coin is coated primarily with latex paint alone and then with additives such as TiO2 and SiO2 nanoparticles separately with the same percentage of concentration. The sample is illumined by a coherent source of light and produces tiny bright and dark fingerprints by the interference effect of the scattered laser. This cigar-like granular pattern image is known as a speckle pattern which is recorded continuously during the drying process of paint. The modified properties due to the additives in paint on the coin are studied by speckle photography. The surface profile plotting method is adopted for the roughness analysis on the sample. Histogram and gray level co-occurrence matrix perform the intensity analysis in the paint. The brightness examine by means of bright/dark pixel counting method.
Multi-tile zinc-oxide-based radiation-hard fast scintillation counter for relativistic heavy-ion beam diagnostics: prototype design and test
Authors: Saifulin M , Boutachkov P , Gorokhova E , Rodnyi P , Trautmann C , Venevtsev I , Walasek-Höhne B 
Published: January 2024

Abstract
This contribution summarizes the design and performance test of a prototype radiation-hard fast scintillation detector based on the indium-doped zinc oxide ceramic scintillator, ZnO(In). The prototype detector has been developed for use as a beam diagnostics tool for high-energy beam lines of the SIS18 synchrotron at the GSI Helmholtz Center for Heavy Ion Research GmbH. The new detector consists of multiple ZnO(In) scintillating ceramics tiles stacked on the front and back sides of a borosilicate light guide. The performance of the detector was tested in comparison to a standard plastic scintillation detector with 300 MeV/u energy 40Ar, 197Au, 208Pb, and 238U ion beams. The investigated prototype exhibits 100% counting efficiency and radiation hardness of a few orders of magnitude higher than the standard plastic scintillation counter. Therefore, it provides an improved beam diagnostics tool for relativistic heavy-ion beam measurements.
Exploring Biophilic Urbanism Indicators Along Urban Waterfronts of Submerged Heritage Cities
Authors: Alashwah Fatma , AbdelTawab Ayman , Eldarwish Ingy , Mehanna Wesam 
Published: January 2024

Abstract
The urban waterfronts of submerged heritage cities offer great opportunities and space for bringing nature into cities, they provide inspiration for closer relationships between nature, heritage sites and society. On the other hand, these urban waterfronts suffer from disconnection between nature and culture in heritage conservation practices. This disconnection has negatively impacted not only on the heritage sites, but also on ecosystems, citizens’ health, and wellbeing. Biophilic urbanism is an approach that seeks to integrate nature into urban waterfront spaces, creating healthier and more liveable cities. This paper aims to fill the gap between nature and cultural in conservation practices by adopting the concept of biophilic urbanism, which provides a valuable tool for conservation the urban waterfronts of submerged heritage cities, in addition to the balance conservation with development and create more resilient waterfront communities. The paper examines case studies of urban waterfronts in (Zadar, Croatia), (Baia, Italy), and (Abo Qir, Egypt). The results indicate the necessity of modifying Abo Qir’s urban waterfront development plan to incorporate indicators of Biophilic urbanism. This adjustment is crucial in order to ensure that future generations inherit healthy and vital living spaces, in addition to preserve Abo Qir’s significant submerged heritage cities.