bluuebunny/crossref_metadata_2025_split huggingface dataset:
Pain in children with Bell’s palsy: secondary analysis of a randomised controlled trial
Authors: Babl Franz E , Eapen Nitaa , Herd David , Borland Meredith L , Kochar Amit , Lawton Ben , Hort Jason , West Adam , George Shane , Davidson Andrew , Cheek John A , Oakley Ed , Hopper Sandy M , Berkowitz Robert G , Wilson Catherine L , Williams Amanda , MacKay Mark T , Lee Katherine J , Hearps Stephen , Dalziel Stuart R 
Published: December 2023

ObjectiveTo describe the prevalence and severity of pain experienced by children with Bell’s palsy over the first 6 months of illness and its association with the severity of facial paralysis.MethodsThis was a secondary analysis of data obtained in a phase III, triple-blinded, randomised, placebo-controlled trial of prednisolone for the treatment of Bell’s palsy in children aged 6 months to <18 years conducted between 13 October 2015 and 23 August 2020 in Australia and New Zealand. Children were recruited within 72 hours of symptom onset and pain was assessed using a child-rated visual analogue scale (VAS), a child-rated Faces Pain Score-Revised (FPS-R) and/or a parent-rated VAS at baseline, and at 1, 3 and 6 months until recovered, and are reported combined across treatment groups.ResultsData were available for 169 of the 187 children randomised from at least one study time point. Overall, 37% (62/169) of children reported any pain at least at one time point. The frequency of any pain reported using the child-rated VAS, child-rated FPS-R and parent-rated VAS was higher at the baseline assessment (30%, 23% and 27%, respectively) compared with 1-month (4%, 0% and 4%, respectively) and subsequent follow-up assessments. At all time points, the median pain score on all three scales was 0 (no pain).ConclusionsPain in children with Bell’s palsy was infrequent and primarily occurred early in the disease course and in more severe disease. The intensity of pain, if it occurs, is very low throughout the clinical course of disease.Trial registration numberACTRN12615000563561.
Metamodernism: A Response About Magic
Authors: Brand Mattias 
Published: December 2023

Abstract
Since Metamodernism presents a vision for the future of theory, one can expect to find fundamental insights to inspire empirical and historical research as well as crucial questions to discuss with graduate students. In this short response, I summarize some of the key terminology of Josephson Storm’s Metamodernism and attempt to apply it to the study of ancient magic. Despite the ambitious aims and density of the book, I would like to connect its theoretical questions concerning realism, ontology, semiotics, and the role of academic values to the day-to-day activities of my scholarship: historical research and teaching within the study of religion\s.
South African Food Studies
Authors: Stanley Ben Jamieson , Lewis Desiree , Mafofo Lynn 
Published: December 2023

Abstract
Introducing a special issue of Matatu titled “South African Food Studies,” this essay argues for the importance of food as a lens for understanding contemporary culture and society. More specifically, the essay advocates for recentring Global South contexts—in this case South Africa—in a ‘food studies’ conversation that has often been dominated by the American academy; it also underscores the vitality of the humanities, qualitative social sciences, and creative arts for transcending reductive ‘food security’ paradigms often applied in the Global South. The essay first examines the short story “Water No Get Enemy” by South African writer Fred Khumalo, introducing how a focus on food and eating can illuminate globalisation, xenophobia, resource conflict, and environmental change. From here, the authors introduce the evolving field of ‘food studies,’ then outline the eight academic, personal, and creative pieces that constitute this special issue, all authored by contributors from the African continent. Issues raised include the gendered and queer politics of food, breastmilk, and soil; the ongoing coloniality of neoliberal approaches to food inequality; the burdening of Black bodies; the role of so-called ‘ethnic restaurants’ in building transnational and multi-ethnic communities; and the heightened stakes of food access during the COVID-19 pandemic.
Becoming Food
Authors: Abrahams Yvette 
Published: December 2023

Abstract
This paper takes a novel perspective on food studies by looking at the role humans play in being food. It encourages us to take a broader view of natural cycles by looking beyond life and death to imagine cycles of birth, life, death, decomposition and nourishment. Every life form feeds another life form; that is the way of Creation. This paper encourages people to think of food as sacrament, and of ourselves as part of a sacred ecology. What does it mean, then, to think of ourselves as food? What obligations does that impose on us to make sure that we are good eating? This essay suggests that eating organically grown food is important for many reasons, but not least because it respects this natural cycle. It does so through a discussion of Eve Balfour, otherwise known as the mother of organic farming. The importance of this topic is underlined by Balfour’s approach to saving the topsoil on which all civilizations depend. Balfour’s ideas on the crucial role of earthworms in soil preservation are examined, and it is suggested that we would do well to take these ideas to heart, and act.
The Unwritten
Authors: Naidoo Pralini 
Published: December 2023

Abstract
For many years, having searched for the foods with which I had grown up within the pages of published recipe books, I realised that there was a lack of written representation around what I had understood as ancestral foods. Neither could I find the voices of the mothers and grandmothers who had fed our bodies and spirits. Through the lens of Indian indenture, a colonial system of servitude that had introduced my ancestors to South Africa, I attempt to understand why. While published recipe books offer multiple readings, they are also powerful forms of knowledge production, contributing to narrow formulations of identity. Power dictates what is published and how. By exploring how recipes live beyond words on the page, I suggest that the possibility exists to revisit hidden food narratives while recognising the creativity, ingenuity, and adaptability of many women, who are usually rendered invisible within food texts. Through poetry, story, and my mother’s handwritten recipe book, I search for my mother and the taste of home.
House of Hunger
Authors: Chipuriro Rejoice Mazvirevesa , Batisai Kezia 
Published: December 2023

Abstract
In South Africa, the politicisation of COVID-19 widened structural fissures, unearthed underlying inequalities, and exposed the ‘rainbow nation’ fallacy. The pandemic highlighted the struggles faced by marginalised households whose income streams were wiped out during lockdown. Public unrest emerged in townships and manifested as food protests, which undermined the perception of South Africa as a food secure country. Whilst the state and mainstream media dismissed these protests as criminal incidences, a contextualised analysis exposes the desperation of certain groups’ experiences of hunger and disillusionment in Black South African townships. Framing ‘food as political’, this paper interrogates the weaponisation of food by the government, which violently used state security forces to subdue marginalised populations. The paper draws on Dambudzo Marechera’s 1978 novella House of Hunger to condemn the gendered and militarised state response to ‘starving black bodies.’ It exposes the ruthlessness of how the state worked with mainstream media to protect corporate capital and foreign investments in the name of ‘security’ and ‘wellbeing,’ and explores the ultimate ‘logic’ of food protests in South African urban areas. In conclusion, the paper argues that the mainstream media hyper-visualised Black bodies as unruly, criminal, and therefore disposable, in order to dismiss their human right to food.
ABO Incompatibility Haploidentical Peripheral Blood Stem Cell Transplantation Combined with a Single Cord Blood Unit for Severe Aplastic Anemia Patients
Authors: Wang Xiaoning , Ren Juan , Zhu Huachao , Zhang Mei , He Pengcheng 
Published: December 2023

Background: For young severe aplastic anemia (SAA) patients without HLA matched donors, haploidentical hematopoietic stem cell transplantation can be used as an alternative selection. The grafts of classic Beijing protocol in China is a combination of bone marrow and peripheral blood stem cell. For patients with major or minor blood type incompatibility, bone marrow stem cells need to undergo red blood cell or plasma removal treatment. There was rare reports about haploidentical peripheral blood stem cell combined with a single unrelated cord blood unit for ABO incompatibility haploidentical stem cell transplantation in SAA patients.
Objective: To observe the efficacy of ABO incompatibility haploidentcial peripheral blood hematopoietic stem cell transplantation combined with a single unrelated cord blood unit for SAA patients.
Method s : Fifty-five SAA patients underwent stem cell transplantation from August 2018 to February 2022 in the First Affiliated Hospital of Xi'an Jiaotong Univeristy were divided into two groups based on donor-recipient ABO compatibility, the donor-recipient ABO matched group（BM+PB group）using haploidentical bone marrow and peripheral blood stem cell as grafts, and donor-recipient ABO mismatched group（CB+PB group）, using unrelated cord blood and haploidentical peripheral blood stem cell as grafts. The differences of hematopoietic reconstitution, acute and chronic GVHD, CMV and EB virus infection, PFS, and OS between the two groups were compared.
Result s : There were 30 cases in CB+PB group and 27 cases in the BM+PB group. Except for differences in donor-recipient ABO compatibility, the other characteristics of the two groups of patients were comparable((P&gt;0.05). One patient in the BM+PB group had primary graft failure, while the rest of the patients were successfully implanted. There were no significant statistical differences in neutrophil,platelet and red blood cells recovery rates, the incidence of acute and chronic GVHD, CMV, EB virus infection, and PTLD between the two groups of patients(P&gt;0.05). There was no significant statistical difference in OS between the two groups of patients(P&gt;0.05)(Figure 1).
Conclusion: For SAA patients with donor-recipient ABO incompatibility could use haploidentical peripheral blood cell combined with unrelated cord blood for transplantation which had compared outcome with haploidentcal bone marrow and peripheral blood cell transplantation.
A Novel Dual Kinase Inhibitor for the Treatment of Chronic Graft Vs. Host Disease
Authors: Miller Alan M , Zhang Liqiang , Hirschfeld Gregg J , Moyer Joseph , Devore Kendra , Murray Maggie , Gonzales Paul , Gately Stephen 
Published: December 2023

Chronic Graft vs. Host Disease (cGvHD) remains a major debilitating and potentially fatal sequelae of allogeneic hematopoietic cell transplantation. Corticosteroids remain the initial therapy of clinically significant cGvHD. Since 2017 three targeted therapies have been approved for steroid refractory cGVHD, ruxolitinib, a JAK 1/2 inhibitor, is approved post one or two previous therapies. Ibrutinib, a Bruton's tyrosine kinase (BTK) inhibitor, and belumosudil, a ROCK2 inhibitor, are both approved after two previous lines of therapy.
We tested RR- RR-1752 a single digit nM dual ROCK/AURK inhibitor in a mouse model of severe cGVHD. BALB/c recipient mice were preconditioned with 7.5 Gy TBI, 8 hours later they received 10 7 T-cell depleted (TCD) C57BL/6 bone marrow cells alone (Group A, n=7) or 10 7 TCD C57Bl bone marrow cells plus 10 6 splenocytes (Groups B, n=8 and C, n=8). Beginning day 7 post cell infusion animals received either oral vehicle control (groups A and B) or vehicle with 1.0 mg/kg RR-1752 (Group C) daily. Body weight, alopecia score and eye score were monitored 3×/week through day 56 or until termination.
All animals in groups B and C developed signs and symptoms of chronic graft vs. host disease. Animals in group A exhibited 20% weight loss through seven days post irradiation and cell infusion but began to recover to baseline and recovered weight to 90% of baseline. Animal weights in groups B and C dropped to less than 80% at day seven post irradiation, but only recovered to 80.38% +/- 10.18 (Group B) and 87.11% +/- 7.90 (Group C) on day 14 and then declined to 74.10% +/- 4.19 in Group B and 80.23% +/- 7.35 in Group C by day 28 (Figure 1). Animals in Group A had no significant change in eye score or alopecia. In contrast all animals in groups B and C showed signs of cGvHD. Eye showed moderate effects in Group B and mild changes in group C, while alopecia scores were moderate in both groups B and C. All animals in group A survived through day 56, median survival in group B was 16.5 days, as compared to 38 days in group C (Figure 2).
In a separate study in normal mice, RR-1752 given at 1.0 mg/kg/day for 2 weeks showed no negative effects on hemoglobin, hematocrit, platelets, total WBC, or neutrophils, and only a mild decrease in lymphocytes.
Using a model for cGVHD, exhibiting weight loss, alopecia, and ocular changes, we demonstrated that RR-1752 1.0 mg/kg/day slows mouse body weight loss, increases survival and shows trends to ameliorate ocular toxicity. The dose tested did not ameliorate the alopecia in the cGVHD mice. Further studies are ongoing to assess higher dose levels and dose schedule effects in the severe cGVHD mouse model. Additional studies to compare effects on cGVHD to ruxolitinib and belumosudil and in combination with those standard of care therapies need to be conducted.
Primary Cutaneous Diffuse Large B-Cell Lymphoma-Leg Type Descriptors and Clinicopathologic Determinants of Survival: Analysis of a Pooled Database
Authors: Haddad Philip A , Amankwah Millicent 
Published: December 2023

Background
Primary Cutaneous Diffuse Large B-cell Lymphoma-Leg Type (PCDLBCL-LT) is a rare but non-indolent subtype of B-cell lymphoma. While most of PCDLBCL-LT starts over the lower extremities, some cases may present at other cutaneous sites. The determinants of survival outcomes in this disease are not very well defined. Therefore, we conducted this pooled database analysis to identify the prognostic factors, clinicopathological characteristics, and therapeutic strategies that influence survival in this disease.
Methods
To study the demographic characteristics, molecular and immunohistochemical signatures, therapeutic interventions, survival, and prognostic factors, we compiled a pooled database of 122 cases that fit the diagnostic criteria for PCDLBCL-LT. Kaplan-Meier survival curves were constructed. Cox proportional hazards model and Log-rank tests were used to assess the influence of demographic and clinicopathologic factors on overall survival (OS) and disease-free survival (DFS).
Results
A total of 122 patients with confirmed PCDLBCL-LT were identified. The median age was 76. There was a male preponderance with M:F of 2.4. Seventy-three percent involved the extremities. The median duration of symptoms before diagnosis was 3.5 months. Involvement of lymph nodes, bone marrow, bone, and CNS occurred in 11%, 3%, 4%, and 3%, respectively. Constitutional symptoms were reported in 5%. The median OS and DFS of the whole group were 39 and 32 months, respectively. Patients younger than 70 had better median DFS (NR vs. 24 months, p=0.02) with a non-significant better median OS. Lymph node involvement (18 vs. 45 months, p=0.006) and stage T3 compared to T1/T2 (16 vs. 41 months, p=0.006) were associated with worse OS. Sex, constitutional symptoms, IHC phenotype, extra-lymphatic/extra-cutaneous organ involvement, and histologic cutaneous patterns did not impact OS. Compared to no treatment, chemotherapy, XRT+/-surgery, and stem cell transplant had numerically better OS without reaching statistical significance (5 vs. 39 vs. 41 vs. NR months, p=0.15). Patients who attained CR as their best response also had a superior median OS compared to responses less than CR and non-responders (61 vs. 23 vs. 11 months, p&lt;0.0001).
Conclusion
This study presents updated clinicopathologic data from a large, pooled cohort of patients with PCDLBCL-LT. It identifies age, lymph node involvement, T stage, type of therapy, and quality of response to treatment as critical determinants of OS.
Clinical Significance of Serum CD155 Levels in Acute Lymphoblastic Leukemia Patients
Authors: Azzazi Mohamed , Hegab Hany M , Said Rasha Magdy Mohamed , Ibrahim Nahed Moawad Ibrahim , Abdelfatah Rana G , Mostafa Mariam A 
Published: December 2023

Background: Acute lymphoblastic leukemia (ALL) is a hematologic malignancy characterized
by poor outcomes in adults. Traditional diagnostic and prognostic markers take into account
clinical data but also rely heavily on expensive and invasive tests such as bone marrow studies
with cytogenetics. CD155 is an adhesion molecule that also modulates immune response in
malignancy. Previous studies have shown that serum CD155 (sCD155) levels are higher in
patients with malignancies, and have demonstrated a correlation between higher levels of
sCD155 and poor outcomes. This study investigated the diagnostic and prognostic value of
sCD155 in adult patients with acute lymphoblastic leukemia.
Methodology: 32 adult patients with acute lymphoblastic leukemia and 15 control patients were
enrolled in this study. Clinical and outcome data were collected from patients and a blood sample
from patients and controls was collected with ELISA testing for sCD155 levels.
Results: sCD155 was found to be significantly higher in patients than controls (p&lt;0.05) and was
significantly associated with bone marrow aspirate blast count. It was not associated with other
clinical parameters including gender, age, initial CBC parameter counts, presence of
lymphadenopathy, presence of CNS infiltration, presence of Philadelphia chromosome, type of
ALL, or risk stratification of ALL besides being associated with hepatosplenomegaly. ROC curve
showed high sensitivity and specificity of sCD155 and Kaplan Meir curve showed a trend
towards worse outcomes in patients with high sCD155 but it was not statistically significant.
Conclusion: sCD155 remains a promising marker for diagnosis of ALL but further studies are
needed to confirm its prognostic value.
Health-Related Quality of Life (HRQL) in Cutaneous T-Cell Lymphoma: Psychological Burden and Influencing Factors from Mycosis Fungoides and Sézary Syndrome Patients in China
Authors: Hsu Tun-Ying , Sun Huiping , Li Zhiming , Huang Wenrong , Xie Linna , Yan Xiaojing , Zhao Haifeng , Kim Ki Hyon , Shi Yuankai 
Published: December 2023

Introduction: Mycosis fungoides (MF) and Sézary syndrome (SS) are the most common subtypes of cutaneous T-cell lymphomas (CTCL). However, beyond the clinical and economic burden, psychological burden from CTCL patients in China has not been reported and requires further evaluation.
Methods: The analysis used data from adults (≥18 years) clinically diagnosed with MF or SS, and have been receiving or have received disease-related treatment in the past year. MF patients with stage IA-IIA, patch or plaque phase were categorized into early stage, while stage IIB-IVA, tumor phase were late stage. All SS patients are late stage. HRQL data from the EQ-5D-5L, Skindex-29 and Functional Assessment of Cancer Therapy - General (FACT-G) were analysed at the item level and scored according to instrument guidelines. Multivariate analyses were used to identify factors associated with poor HRQL.
Results: Data were collected from a quantitative survey of 56 MF patients and 5 SS patients residing in 38 cities of 21 provinces across China: 56% were male, with a mean (SD) age of 39 (13) years (median was 38, ranged 19 to 74 years old). 51% were late stage. Based on emotional domain questions of Skindex-29, among all patients, 39% always or often worried about the disease progression, while 45% of late-stage patients were always and often worried. 36% of all patients often or always felt CTCL was annoying. Based on FACT-G, in physical well-being domain, 39% of all patients, and 48% of late-stage patients felt they were ill in “quite a bit” or “very much” scale, respectively. In social well-being domain, 35% of all, and 39% of early-stage patients felt “not at all” or only “a little bit” satisfied with their sex life. In emotional well-being domain, 38% of all patients were “not at all” or “a little bit” satisfied with their coping with the disease, while 36% of all patients “quite a bit” or “very much” worried about the condition getting worse. In the functional well-being domain, 29% of all patients felt they were “not at all” or “a little bit” able to work.
In multivariate analysis, regression on EQ-5D-5L score showed that younger patients were more likely to report severe anxiety and depression. Skindex-29 score showed that female patients worried more that the disease get more serious and causing scars on their skin.
Conclusions: In China, psychological burden with MF and SS, included anxiety, depression, worrying about disease progression, unable to work, and unsatisfied sex life. Younger patients and female patients reported greater psychological impact of the disease. Optimal medical management of MF and SS should address psychological impacts of the disease.