bluuebunny/crossref_metadata_2025_split huggingface dataset:
After all, do findings from clinical physical activity interventions among breast cancer patients apply to all socioeconomic groups? A systematic review of representativeness
Authors: Stalsberg Ragna , Darvik Monica Dahle 
Published: December 2023

Abstract

Background
Considering the widening social health inequalities, socioeconomic representativeness in clinical trials is essential to analyses of feasibility and validity relating to socioeconomic groups. Physical activity trials on breast cancer patients are particularly relevant because the relationship between socioeconomic status and disease burden reverses after diagnosis and because low socioeconomic groups appear less inclined initially to engage in the type of activity commonly prescribed in such trials. A step-by-step exclusion process in which low-socioeconomic groups are less likely to register if at all included, adhere well, and to complete the intervention, could reinforce health inequality. Hence, our aim was to a) examine representativeness in physical activity trials on breast cancer patients, b) investigate the association between socioeconomic status and physical activity intervention adherence, and c) explore associations between representativeness and the relationship between socioeconomic status and intervention adherence.
Methods
Systematic, computerized searches for articles reporting physical activity trials in breast cancer patients were performed in PubMed, CINAHL, AMED, EMBASE and PsycINFO. Additional citation-based searches resulted in 37 articles. In articles where education, marital status or ethnicity were used as indicators of socioeconomic status, we compared the distribution of socioeconomic groups in the study sample and the country where the study was conducted. Through such proxy calculations, we estimated the studies' socioeconomic representativeness.
Results
Of the 30 studies that applied education as an indicator of socioeconomic status, 23 favoured high-socioeconomic groups; Of the 18 American studies where ethnicity was the socioeconomic indicator, 15 favoured white participants. The difference between study samples and country population was less pronounced in studies where marital status was the socioeconomic indicator. Only six studies reported associations between socioeconomic status and trial adherence, hampering solid conclusions on this relationship and possible associations between estimated representativeness and a socioeconomic status and trial adherence relationship.
Conclusions
Non whites and patients with low education are underrepresented in physical activity trials on breast cancer patients. Using leisure-time physical activity in breast cancer treatment may not be suitable for all groups. Hence, the results from most of these studies may be considered inequitable with regard to different socioeconomic status.
Is tuna ecolabeling causing fishers more harm than good?
Authors: Nakamura Katrina 
Published: December 2023

Abstract
Nearly 70,000 fishing crew are currently at sea catching the ecolabeled tuna in your sandwich or sushi. Their catch equals half of the world’s tuna supply. The purpose of this research was to collect tuna data from the website of the Marine Stewardship Council (fisheries/msc.org) to learn what the data reveal about protecting tuna fishers from labour violations while fishing on certified vessels. The standard-setter does not have a fishing labour standard but posts data to its website (fisheries/msc.org) it says demonstrate that vessels in the program operate with well-managed labour risks. To confirm this, a database of 3260 tuna vessels was built from vessel lists, annual catches, and labour statements and queried for fishing job identifiers. Fishing employers (vessel owners) were identified in the vessel data for 1291 vessels representing 26% of the ecolabeled tuna catch. In labour statements, employers were identified for 1238 vessels and 14% of the tuna catch. Flag state labour laws were identified for 1617 vessels and 50% of the tuna catch. Few tuna vessels were owned by the certificate-holding entities (4%) that submitted labour statements and these data were scant on vessel practices. Certificate-holders disavowed debt bondage, forced and child labour as “non-applicable” on MSC-engaged vessels overall. Jobs, risks, and vessel employment practices could not be tracked from the data. Seven vessels currently listed in the program were reported by fishers for forced labour. Yet, all owners of certified vessels gain logo rights and benefits, due to certification’s pooling mechanism.
5-hydroxymethylcytosine Profilings in Circulating Cell-free DNA as diagnostic biomarkers for DLBCL
Authors: Duolikun Maimaitiyasen , Ding Yangming , Zhang Lei , Li Xuehui , Xiao Hong , Kuerban Subinuer , Zhen Baixin , Wang Yuxi , Chen Long , Chen Hang-yu , Lin Jian 
Published: December 2023

Abstract
Background
5-Hydroxymethylcytosine (5hmC) is an important DNA epigenetic modification that plays a vital role in tumorigenesis, progression and prognosis. Previous studies have shown that it plays an important role in the prognosis of diffuse large B-cell lymphoma (DLBCL) and in the prediction of the efficacy of R-CHOP therapy. However, its potential for diagnosing DLBCL has not been reported. Here, we investigated the utility of 5hmC in plasma cfDNA in the diagnosis of DLBCL.
Methods
Applying 5hmC-Seal technique, we obtained genome-wide 5hmC profiles in plasma cell-free DNA (cfDNA) samples from 176 Chinese subjects, included 86 DLBCL patients and 90 healthy controls. To investigate whether 5hmC can be used as a diagnostic biomarker for DLBCL, we separated patients and healthy controls into training (DLBCL = 56, Healthy = 60) and validation (DLBCL = 30, Healthy = 30) cohorts and developed a 5hmC-based logistic regression model from the training cohort to diagnose the DLBCL patients in the validation cohort.
Results
In this study, we found 10 5hmC biomarkers, and the models created by these differentially regulated 5hmC modified genes showed high accuracy in distinguishing DLBCL patients from healthy controls (validation cohort: AUC = 0.94; (95% CI 88.8% − 99.4%)).
Conclusions
Our study suggested that 5hmC markers derived from plasma cfDNA can served as effective epigenetic biomarkers for minimally invasive diagnosis of DLBCL.
MAPNet: A Multi-scale Attention Pooling Network for Ultrasound Medical Image Segmentation
Authors: Wang Shixun , Wang Mengjiao 
Published: December 2023

Abstract
Deep convolutional neural networks have achieved great success in the field of medical image segmentation and assisted diagnosis due to their excellent autonomous feature extraction capability and good feature representation ability. Traditional convolutional neural networks usually use standard convolutional layers to extract features. However, in medical image segmentation, a pixel may correspond to multiple different scale structures, such as lesion edges, organ boundaries, etc. Therefore, traditional convolutional layers may not be able to capture this complex feature. In this paper, we propose a multi-scale convolution (MC) which realizes more comprehensive feature extraction by introducing multiple differently sized convolution kernels. Additionally, a novel multi-scale attention pooling network (MAPNet) is proposed, including a multi-scale pooling convolution block that combines pooling with multi-scale attention gates to better focus and utilize feature information at different scales and achieves effective skip connections. The proposed model is evaluated on two different medical image segmentation datasets, and the results show that our model achieves good performance in terms of speed and accuracy.
Towards Understanding the Impact of European Agriculture on Biodiversity with an Updated Hierarchical Crop and Agriculture Taxonomy (HCAT)
Authors: Schneider Maja , Gackstetter David , Prexl Jonathan , Meyer Sebastian T. , Körner Marco 
Published: December 2023

Abstract
Modern agriculture plays a significant role in driving the decline of global biodiversity. The homogenization of landscapes, the reduction of natural habitats, and the intense use of pesticides are substantial factors for natural species populations to shrink or even disappear. However, despite significant advances in research, still today, the impacts of cropping systems on biodiversity are challenging to quantify. One primary reason for this is the lack of available agricultural data. The data from the Integrated Administration and Control System (IACS) of the European Union’s (EU) Common Agricultural Policy (CAP) give new potential to improve the basis of information for agroecological research in Europe. Within the framework of the CAP, European farmers are required to declare their cropping arrangements to official authorities to receive corresponding subsidies in exchange. The nationally applied crop taxonomies are, however, not harmonized across Europe, which hinders transnational analyses of agriculture and its environmental impacts. To overcome this barrier, we developed a Hierarchical Crop and Agriculture Taxonomy (HCAT) to harmonize administrative, agricultural data from 16 EU member states. With the release of our upgraded second version of HCAT, we demonstrate that a harmonized CAP data set can aid in unraveling the intricate connections between agricultural crop management and biodiversity at both national and international scales.
Survivorship Program Including Long-Term Toxicities and Quality-of-Life Development Over Ten Years within a Randomized Phase-III Trial in Operable Stage III Non-Small-Cell Lung Cancer (ESPATUE)
Authors: Schulte Christina , Gauler Thomas Christoph , Pöttgen Christoph , Friedel Godehard , Kopp Hans-Georg , Schmidberger Heinz , Kimmich Martin , Cordes Sebastian , Wienker Johannes , Metzenmacher Martin , Budach wilfried , Rios Rodrigo Hepp de Los , Spengler Werner , De Ruysscher Dirk , Belka Claus , Welter Stefan , Luetke-Brintrup Diana , Guberina Maja , Oezkan Filiz , Darwiche Kaid , Schuler Martin , Joeckel Karl-Heinz , Aigner Clemens , Stamatis Georgios , Stuschke Martin , Eberhardt Wilfried Ernst Erich 
Published: December 2023

Abstract
Purpose
Over 40% stage-III non-small-cell lung cancer patients experience five-year survival following multimodality treatment. Little is known about relevant late toxicities and quality-of-life (QoL) ten years from diagnosis.
Methods
We invited long-term follow-up-patients from our randomized phase-III trial (Eberhardt et al., Journal of Clinical Oncology 2015) to participate within a structured survivorship program (SSP) including follow-up imaging, laboratory parameters, cardio-pulmonary investigations and long-term toxicity evaluations. QoL questionnaires at 10-years were compared to baseline and early follow-up on exploratory basis.
Results
Of 246 patients included, 161 evaluated potentially resectable after induction were randomized to definitive chemoradiation boost (A; 80) or definitive surgery (B; 81) (85 not randomized (C)). 31 of 37 patients (OS > 10 yrs) agreed to the SSP (A:13, B:12, C:6). Significant long-term toxicities of 3°/4° were rarely observed (lung(FEV1) 3° A:0/9, B:1/6, C:0/5; 4° A:1/9, B:0/6, C:1/5; no 3°/4° cardiac toxicity, no 3°/4° chronic kidney disease, no 3°/4° polyneuropathy). A:5/12, B:1/10 and C:1/6 patients showed relevant nutritional disorders (obesity 3°). QoL analysis of both arms showed no relevant signals of worsening compared to earlier and baseline results. Mean QoL in SSP A: 56.41/100 pts., B: 64.39/100 pts., C: 59.72/100 pts.
Conclusions
Long-term surviving patients following definitive chemoradiation or surgery showed comparable long-term toxicities and QoL assessments. Most patients are in good clinical status.
Implications for Cancer Survivors
This is the first comprehensive SSP reported in stage-III NSCLC treated within a randomized multimodality trial and may serve as baseline information for physician and patient deciding for a treatment option.
Transformational leadership and employee’s career satisfaction: Role of psychological empowerment, organisational commitment, and emotional exhaustion
Authors: Syed Ali Raza  , Sara Qamar Yousufi  
Published: December 2023

Transformational leadership is essential for employees’ empowerment as it significantly enhances leadership qualities and increases employees’ satisfaction. Accordingly, the lack of comprehensive exploration and understanding has motivated us to examine the relationship between transformational leadership, psychological empowerment, organisational commitment, career satisfaction, and the moderating role of emotional exhaustion. The objectives of this study are (1) to study the relationship between transformational leadership, psychological empowerment, organisational commitment, and career satisfaction of employees, (2) to evaluate the mediating role of psychological empowerment and organisational commitment in relationship between transformational leadership and career satisfaction, and (3) to evaluate moderating role of emotional exhaustion on relationship between transformational leadership, psychological empowerment, and organisational commitment. Data was collected via cross-sectional structured questionnaires by 513 bank employees. Results indicate that transformational leadership significantly relates to empowerment and organisational commitment of employees but is insignificantly associated with career satisfaction. Moreover, transformational leadership significantly influences employees’ career satisfaction through the mediation of empowerment and commitment. Moderation analyses revealed that higher emotional exhaustion weakens employees’ empowerment and transformational leadership, which further weakens the direct relationship between transformational leadership and psychological empowerment and association between transformational leadership and commitment. This research can assist managers in developing retention strategies for employees to enhance psychological empowerment, organisational commitment, and career satisfaction of employees.
Why cognitive absorption is not enough: The role of knowledge absorption capacity and technological opportunity for individual learning
Authors: Ahmad Adeel  , Samreen Batool  , Daisy Mui Hung Kee  , Zain-ul-Abdeen Madni  
Published: December 2023

The purpose of this paper is to address the basic question why does high absorptive training programmes are not always beneficial for individual level learning? Thus, we seek to understand when and how cognitive absorption is beneficial for individual learning. The proposed model was tested using data obtained in a field study (N = 371) and in an experiment (N = 119). For field study, data was obtained at two points in time from three data sources (co-workers, subordinates, supervisors) working at a private commercial bank operating in Pakistan. For laboratory experiment, data was collected from the business students of a private sector university in Pakistan. The obtained data for both studies were analysed for random coefficient models with Mplus. Based on the motivation-ability-opportunity theory of behaviour, we proposed a model. It was found that cognitive absorption and highest individual learning was contingent upon the individual level knowledge absorption capacity. It was further found that training programmes with high cognitive absorption are likely to produce high levels of individual learning when the participants also have both high level of knowledge absorption capacity and technological opportunity. With this research, we inform practitioners that in these learner-focused trainings, personal characteristics of the participants and technology play vital role in determining effectiveness for high level of individual learning. The research findings will help practitioners understand what they need to add in training programmes for high level individual learning experience. Doing so will bring best value in form of higher learning to the cost of trainings.
The use of wild berries in soft cheese technology
Authors: Eliseeva Lyudmila , Stepanov Konstantin , Egorova Veronida 
Published: December 2023

A functional soft cheese has been developed with the addition of rosehip fruits, the most common type of rosehip with a wide variety of populations in Yakutia. The objects of the study were cow’s milk, rosehip fruits, sourdough prepared on Bulgarian stick
cultures, milk whey, whey that is obtained at the stages of cheese production and ready-made cheese with an additive During the experiments, the effects of additives on organoleptic parameters and the biochemical composition of cheese were studied. According to the results of the study, the expediency of using rosehip fruits in the production technology of soft cheese is justified.
Integration of machine learning and hydrodynamic modeling to solve the extrapolation problem in flood depth estimation
Authors: Nguyen Huu Duy , Dang Dinh Kha , Nguyen Nhu Y , Pham Van Chien , Van Nguyen Thi Thao , Nguyen Quoc-Huy , Nguyen Xuan Linh , Pham Le Tuan , Pham Viet Thanh , Bui Quang-Thanh 
Published: December 2023

Abstract
Flood prediction is an important task, which helps local decision-makers in taking effective measures to reduce damage to the people and economy. Currently, most studies use machine learning to predict flooding in a given region; however, the extrapolation problem is considered a major challenge when using these techniques and is rarely studied. Therefore, this study will focus on an approach to resolve the extrapolation problem in flood depth prediction by integrating machine learning (XGBoost, Extra-Trees (EXT), CatBoost (CB), and light gradient boost machines (LightGBM)) and hydraulic modeling under MIKE FLOOD. The results show that the hydraulic model worked well in providing the flood depth data needed to build the machine learning model. Among the four proposed machine learning models, XGBoost was found to be the best at solving the extrapolation problem in the estimation of flood depth, followed by EXT, CB, and LightGBM. Quang Binh province was hit by floods with depths ranging from 0 to 3.2 m. Areas with high flood depths are concentrated along and downstream of the two major rivers (Gianh and Nhat Le – Kien Giang).
Multipurpose optimization of yield production in agriculture using fuzzy self-reproducing automata theory
Authors: He Defu , Liu Nan 
Published: December 2023

Abstract

In determining the irrigation depth of barley, it is inevitable to find the best periods to increase the efficiency of water consumption and also to achieve the highest yield of the product. A multi-objective optimization model has been presented to improve irrigation planning and the allowable amount of irrigation during the growth period using genetic algorithm based on nondominated sorting (NSGAII) and cellular automata. Under this concept, the structure of the optimal water supply allocation model is included in the form of two main objective functions. Therefore, the first objective function is to minimize water allocation and the second objective function is to maximize the total income from the cultivation pattern compared to its costs. The latest data related to the cultivation pattern and economic information such as product sales price and production costs in the planting and harvesting stages were collected for 1 year of study. The daily data of river flow, rainfall and climatic data of Hulunbuir district in Inner Mongolia province were converted into 10-day periods. It shows the optimal irrigation planning results of winter barley in three different scenarios. In ten periods of growth, the rainfall is enough to provide most of the plants’ water needs.
Hydrolytic degradation of methoxychlor by immobilized cellulase on LDHs@Fe3O4 nanocomposites
Authors: Iqbal Nazar , Mu Guangda , Dong Mengyang , Yang Yuxiang , Huang Yan , Yuan Hongming , Liu Xiangnong , Batool Irum , Carlini Riccardo 
Published: December 2023

Abstract

In this study, we synthesized Fe3O4 using the co-precipitation method and then prepared magnetic carrier LDHs@Fe3O4 by immobilizing layered double hydroxide on Fe3O4 by in situ growth method. Cellulase was immobilized on this magnetic carrier by using glutaraldehyde as a coupling agent, which can be used for degrading Methoxychlor (MXC). The results demonstrated the maximum MXC removal efficiency of 73.4% at 45 °C and pH = 6.0 with excellent reusability. Through kinetic analysis, it was found that the degradation reaction conforms to the Langmuir–Hinshelwood model and is a first-order reaction. Finally, according to the EPR analysis, the active radicals in the system were found to be OH· and the degradation mechanism was proposed in combination with LC-MS. This study provides a feasible method for degrading organochlorine pesticides, which can be used for groundwater purification.
Strategies to Minimize Access Site-related Complications in Patients
Undergoing Transfemoral Artery Procedures with Large-bore Devices
Authors: Sorrentino Sabato , Di Costanzo Assunta , Salerno Nadia , Caracciolo Alessandro , Bruno Federica , Panarello Alessandra , Bellantoni Antonio , Mongiardo Annalisa , Indolfi Ciro 
Published: December 2023

Abstract:
Large bore accesses refer to accesses with a diameter of 10 French or greater and are necessary
for various medical devices, including those used in transcatheter aortic valve replacement,
endovascular aneurysm repair stent-grafts, and percutaneous mechanical support devices. Notably,
the utilization of these devices via femoral access is steadily increasing due to advancements in technology
and implantation techniques, which are expanding the pool of patients suitable for percutaneous
procedures. However, procedures involving large bore devices carry a high risk of bleeding and
vascular complications (VCs), impacting both morbidity and long-term mortality.

:
In this review article, we will first discuss the incidence, determinants, and prognostic impact of VCs
in patients undergoing large bore access procedures. Subsequently, we will explore the strategies
developed in recent years to minimize VCs, including techniques for optimizing vascular puncture
through femoral cannulation, such as the use of echo-guided access cannulation and fluoroscopic
guidance. Additionally, we will evaluate existing vascular closure devices designed for large bore
devices. Finally, we will consider new pharmacological strategies aimed at reducing the risk of periprocedural
access-related bleeding.