bluuebunny/crossref_metadata_2025_split huggingface dataset:
Sex differences in type 2 diabetes: an opportunity for personalized medicine
Authors: Johnson Meredith L. , Preston Joshua D. , Rashid Cetewayo S. , Pearson Kevin J. , Ham J. Nina 
Published: December 2023

AbstractOver the past several decades, substantial ground has been gained in understanding the biology of sex differences. With new mandates to include sex as a biological variable in NIH-funded research, greater knowledge is forthcoming on how sex chromosomes, sex hormones, and social and societal differences between sexes can affect the pathophysiology of health and disease. A detailed picture of how biological sex impacts disease pathophysiology will directly inform clinicians in their treatment approaches and challenge canonical therapeutic strategies. Thus, a profound opportunity to explore sex as a variable in personalized medicine now presents itself. While many sex differences are apparent in humans and have been described at length, we are only beginning to see how such differences impact disease progression, treatment efficacy, and outcomes in obesity, type 2 diabetes, and cardiovascular disease. Here, we briefly present the most salient and convincing evidence of sex differences in type 2 diabetes detection, diagnostics, disease course, and therapeutics. We then offer commentary on how this evidence can inform clinicians on how to approach the clinical workup and management of different patients with diabetes. Finally, we discuss some gaps that remain in the literature and propose several research questions to guide basic and translational researchers as they continue in this growing area of scientific exploration.
Protective efficacy of multiepitope vaccines constructed from common antigens of Eimeria species in chickens
Authors: Chen Chen , Su Junzhi , Lu Mingmin , Xu Lixin , Yan Ruofeng , Li Xiangrui , Song Xiaokai 
Published: December 2023

AbstractClinical avian coccidiosis is typically caused by coinfection with several Eimeria species. Recombinant protein and DNA vaccines have shown promise in controlling coccidiosis. On this basis, DNA vaccines that encode multiple epitopes from different Eimeria species may provide broad protection against coinfections. In this study, we designed a fusion gene fragment, 14EGT, that contained concentrated T-cell epitopes from four common antigens of Eimeria species (14-3-3, elongation factor 2, glyceraldehyde-3-phosphate dehydrogenase, and transhydrogenase). The multiepitope DNA vaccine pVAX1-14EGT and recombinant protein vaccine pET-32a-14EGT (r14EGT) were then created based on the 14EGT fragment. Subsequently, cellular and humoral immune responses were measured in vaccinated chickens. Vaccination-challenge trials were also conducted, where the birds were vaccinated with the 14EGT preparations and later exposed to single or multiple Eimeria species to evaluate the protective efficacy of the vaccines. According to the results, vaccination with 14EGT preparations effectively increased the proportions of CD4+ and CD8+ T cells and the levels of Th1 and Th2 hallmark cytokines. The levels of serum IgG antibodies were also significantly increased. Animal vaccination trials revealed alleviated enteric lesions, weight loss, and oocyst output compared to those of the control groups. The preparations were found to be moderately effective against single Eimeria species, with the anticoccidial index (ACI) ranging from 160 to 180. However, after challenge with multiple Eimeria species, the protection provided by the 14EGT preparations was not satisfactory, with ACI values of 142.18 and 146.41. Collectively, the results suggest that a multiepitope vaccine that encodes the T-cell epitopes of common antigens derived from Eimeria parasites could be a potential and effective strategy to control avian coccidiosis.
Frailty’s influence on 30-day mortality in old critically ill ICU patients: a bayesian analysis evaluating the clinical frailty scale
Authors: Wernly Bernhard , Bruno Raphael Romano , Beil Michael , Flaatten Hans , Kelm Malte , Sigal Sviri , Szczeklik Wojciech , Elhadi Muhammed , Joannidis Michael , Koköfer Andreas , Oeyen Sandra , Marsh Brian , Moreno Rui , Wernly Sarah , Leaver Susannah , De Lange Dylan W. , Guidet Bertrand , Jung Christian 
Published: December 2023

Abstract
Introduction
Frailty is widely acknowledged as influencing health outcomes among critically ill old patients. Yet, the traditional understanding of its impact has predominantly been through frequentist statistics. We endeavored to explore this association using Bayesian statistics aiming to provide a more nuanced understanding of this multifaceted relationship.

Methods
Our analysis incorporated a cohort of 10,363 older (median age 82 years) patients from three international prospective studies, with 30-day all-cause mortality as the primary outcome. We defined frailty as Clinical Frailty Scale ≥ 5. A hierarchical Bayesian logistic regression model was employed, adjusting for covariables, using a range of priors. An international steering committee of registry members reached a consensus on a minimal clinically important difference (MCID).

Results
In our study, the 30-day mortality was 43%, with rates of 38% in non-frail and 51% in frail groups. Post-adjustment, the median odds ratio (OR) for frailty was 1.60 (95% CI 1.45–1.76). Frailty was invariably linked to adverse outcomes (OR > 1) with 100% probability and had a 90% chance of exceeding the minimal clinically important difference (MCID) (OR > 1.5). For the Clinical Frailty Scale (CFS) as a continuous variable, the median OR was 1.19 (1.16–1.22), with over 99% probability of the effect being more significant than 1.5 times the MCID. Frailty remained outside the region of practical equivalence (ROPE) in all analyses, underscoring its clinical importance regardless of how it is measured.

Conclusions
This research demonstrates the significant impact of frailty on short-term mortality in critically ill elderly patients, particularly when the Clinical Frailty Scale (CFS) is used as a continuous measure. This approach, which views frailty as a spectrum, enables more effective, personalized care for this vulnerable group. Significantly, frailty was consistently outside the region of practical equivalence (ROPE) in our analysis, highlighting its clinical importance.
Evidence at source for the mid-fifteenth century eruption of Kuwae, Vanuatu
Authors: Ballard Chris , Bedford Stuart , Cronin Shane J. , Stern Sönke 
Published: December 2023

AbstractThe mid-fifteenth century eruption of the Kuwae volcano (Vanuatu), known locally as the Tombuk eruption, is widely but not universally considered responsible for one of the three largest atmospheric sulphate events of the past millennium. Questions remain about its precise magnitude and global signature. This controversy reflects a lack of modern description and characterisation of the eruption at source. Through a comprehensive survey of the published and unpublished literature, we review the available historical, archaeological and volcanological evidence for the Kuwae eruption. All sources suggest an eruption with major impacts regionally. The eruption formed a submarine caldera, collapsing the former landmass of Kuwae and leaving two smaller adjacent islands, Epi and Tongoa. On other islands to the immediate south and north, volcanic impacts were variable, enabling survival of refugees from Kuwae, who later recolonised the remnant islands. This review raises hypotheses and questions to be tested through a new multi-disciplinary field research program that aims to establish the precise date and magnitude of the Tombuk eruption, allowing questions of global impact to be addressed with more confidence.
Attributes of errors, facilitators, and barriers related to rate control of IV medications: a scoping review
Authors: Park Jeongok , You Sang Bin , Ryu Gi Wook , Kim Youngkyung 
Published: December 2023

Abstract
Background
Intravenous (IV) medication is commonly administered and closely associated with patient safety. Although nurses dedicate considerable time and effort to rate the control of IV medications, many medication errors have been linked to the wrong rate of IV medication. Further, there is a lack of comprehensive studies examining the literature on rate control of IV medications. This study aimed to identify the attributes of errors, facilitators, and barriers related to rate control of IV medications by summarizing and synthesizing the existing literature.

Methods
This scoping review was conducted using the framework proposed by Arksey and O’Malley and PRISMA-ScR. Overall, four databases—PubMed, Web of Science, EMBASE, and CINAHL—were employed to search for studies published in English before January 2023. We also manually searched reference lists, related journals, and Google Scholar.

Results
A total of 1211 studies were retrieved from the database searches and 23 studies were identified from manual searches, after which 22 studies were selected for the analysis. Among the nine project or experiment studies, two interventions were effective in decreasing errors related to rate control of IV medications. One of them was prospective, continuous incident reporting followed by prevention strategies, and the other encompassed six interventions to mitigate interruptions in medication verification and administration. Facilitators and barriers related to rate control of IV medications were classified as human, design, and system-related contributing factors. The sub-categories of human factors were classified as knowledge deficit, performance deficit, and incorrect dosage or infusion rate. The sub-category of design factor was device. The system-related contributing factors were classified as frequent interruptions and distractions, training, assignment or placement of healthcare providers (HCPs) or inexperienced personnel, policies and procedures, and communication systems between HCPs.

Conclusions
Further research is needed to develop effective interventions to improve IV rate control. Considering the rapid growth of technology in medical settings, interventions and policy changes regarding education and the work environment are necessary. Additionally, each key group such as HCPs, healthcare administrators, and engineers specializing in IV medication infusion devices should perform its role and cooperate for appropriate IV rate control within a structured system.
Prevalence of herbal and traditional medicine in Ethiopia: a systematic review and meta-analysis of 20-year studies
Authors: Tuasha Nigatu , Fekadu Sintayehu , Deyno Serawit 
Published: December 2023

Abstract
Background
The widely accepted prevalence of traditional medicine (TM) in Ethiopia was about 80 %, of which 95 % were sourced from plants. The purpose of this study was to update knowledge of the prevalence of herbal medicine or TM in Ethiopia and describe the characteristics of the population mostly relying on herbal medicine or TM to inform health policy-makers.

Methods
PubMed, Google Scholar, Hinari, Scopus, and the Directory of Open Access Journals (DOAJ) were searched. The methodological quality of each included study was assessed using the quality assessment checklist for prevalence studies. Meta-analysis was conducted using STATA version 17, and the heterogeneity between studies was assessed using I2 test statistics based on the random effect model. Forest and funnel plots were used to present the data. Subgroup analysis was done by the study population, region, and setting.

Results
Thirty-six studies with a total of 16,288 participants met the inclusion criteria. Meta-analysis of the study revealed that the prevalence of herbal medicine use in Ethiopia is 46 % (95 % CI, 37–54 %), with significant heterogeneity among the studies (I2 = 99.19 %). Egger’s test for publication bias of herbal medicine use revealed significant results (Egger, P = 0.002) which indicates possible missing of small sample size studies. The prevalence of TM use in Ethiopia is 65 % (95 % CI, 52–77 %) with significant heterogeneity among the studies (I2 = 99.18 %). Egger’s test for publication bias of TM use revealed non-significant results (Egger, P = 0.275). The subgroup analysis by the study setting and the region revealed variability amongst the studies. Community-based studies and Oromia National Regional State showed higher prevalence. By population type, a higher prevalence of TM use was observed amongst children and lowest amongst malaria suspects.

Conclusions
The current study revealed that TM/herbal medicine utilization remained an important source of primary healthcare in Ethiopia. In comparison to the commonly reported prevalence of TM/herbal medicine, there is a considerable decline in TM/herbal medicine prevalence. High TM/herbal medicine use tendency during pregnancy necessitates safety studies to optimize the utilization.
Radial solutions of p-Laplace equations with nonlinear gradient terms on exterior domains
Authors: Li Yongxiang , Li Pengbo 
Published: December 2023

AbstractThis paper studies the existence of radial solutions of the boundary value problem of p-Laplace equation with gradient term $$ \textstyle\begin{cases} -\Delta_{p} u= K( \vert x \vert ) f( \vert x \vert , u, \vert \nabla u \vert ) ,\quad x\in\Omega , \\ \frac{\partial u}{\partial n}=0 ,\quad x\in\partial\Omega, \\ \lim_{ \vert x \vert \to\infty}u(x)=0 , \end{cases} $$

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Supplementation with high-GABA-producing Lactobacillus plantarum L5 ameliorates essential tremor triggered by decreased gut bacteria-derived GABA
Authors: Zhong Hao-Jie , Wang Si-Qi , Zhang Ruo-Xin , Zhuang Yu-Pei , Li Longyan , Yi Shuo-Zhao , Li Ying , Wu Lei , Ding Yu , Zhang Jumei , Xie Xinqiang , He Xing-Xiang , Wu Qingping 
Published: December 2023

Abstract
Background
The γ-aminobutyric acid (GABA) hypothesis posits a role of GABA deficiency in the central nervous system in the pathogenesis and progression of essential tremor (ET). However, the specific causative factor for GABA deficiency is not clear. The gut microbiota in mammals has recently been considered as a significant source of GABA. Furthermore, the GABA-based signals originating from the intestine can be transmitted to the brain through the “enteric nervous system–vagus nerve–brain” axis. However, the plausible contribution of gut microbiota to ET seems inspiring but remains obscure.

Methods
Fecal samples from patients with ET and healthy controls were examined by metagenomic sequencing to compare the composition of gut microbiota and the expression of genes involved in GABA biosynthesis. The impact of gut microbiota on ET was explored through transplantation of fecal microbiota from patients with ET into the murine ET model. Lactic acid bacteria producing high amounts of GABA were identified through whole-genome sequencing and ultra-performance liquid chromatography-tandem mass spectrometry. Subsequently, mice were treated with the high-GABA-producing strain Lactobacillus plantarum L5. Tremor severity, behavioral tests, pro-inflammatory cytokines, GABA concentration, and gut microbiota composition were examined in these mice.

Results
The gut microbiota of patients with ET demonstrated an impaired GABA-producing capacity and a reduced fecal GABA concentration. Transplantation of the gut microbiota from patients with ET induced an extension of tremor duration and impaired mobility in the murine model of ET. L5 exhibited an augmented GABA-producing capacity, with the De Man-Rogosa-Sharpe culture broth containing 262 mg/l of GABA. In addition, administration of L5 significantly decreased the tremor severity and enhanced the movement capability and grasping ability of ET mice. In vivo mechanistic experiments indicated that L5 reshaped the gut microbial composition, supplemented the mucosa-associated microbiota with GABA-producing capacity, increased the GABA concentrations in the cerebellum, and diminished inflammation in the central nervous system.

Conclusions
These findings highlight that deficiency of GABA-producing gut microbes plays an essential role in the pathogenesis of ET and that L5 is a promising candidate for treating ET.
Considerations for the genotoxicity assessment of middle size peptide drugs containing non-canonical amino acid residues
Authors: Mishima Masayuki , Sugiyama Kei-ichi 
Published: December 2023

Abstract
Background
Middle size peptides (MSPs) have emerged as a promising new pharmaceutical modality. We are seeking the best way to assess the non-clinical safety of MSPs.

Consideration
The requirements for assessing the genotoxicity of pharmaceuticals differ between small molecule drugs and biotherapeutics. Genotoxicity tests are necessary for small molecule drugs but not for biotherapeutics. MSPs, however, share similarities with both small molecule drugs and biotherapeutics. Here, we describe important points to consider in assessing the genotoxicity of MSP drugs. The current standard of genotoxicity assessment for small molecules may not be entirely appropriate for MSP drugs. MSP drugs need genotoxicity assessment mostly according to the current standard of small molecule drugs.

Conclusion
We propose a few modifications to the standard test battery of genotoxicity tests, specifically, the inclusion of an in vitro gene mutation test using mammalian cells, and exclusion of (Q)SAR assessment on MSP-related impurities.
Efficacy of single burr hole with irrigation and sub-dural drain in the evacuation of chronic subdural hematoma
Authors: Gomaa Mahmoud Ahmed , Osman Ashraf Abdellatif , Aboelhuda Ahmed Hosameldin 
Published: December 2023

Abstract
Background
Chronic subdural hematoma (CSDH) remains one of the most common types of traumatic and spontaneous intracranial hematomas. The optimal method of treatment has not been definitely established. Surgical treatment options includes craniotomy, trephination, burrhole drainage and twist drill perforation. This study aimed at the evaluation of the clinical and radiological outcome after the efficacy of single burr hole with irrigation and sub-dural drain in the aim of successful evacuation of CSDH.

Results
A total of 53 patients were included in this study, the mean age of patients was 61.53 + 13.81 years. Results of the paired t test showed that the Glasgow coma scale has significantly improved by 0.89 points (p < 0.001) and that the average motor power has significantly improved for all individuals by 0.4 points (p = 0.043). We found that older aged patients have significantly less improvements in the postoperative motor power (r = − 0.317, p = 0.02) and require longer hospital stay (r = 0.32, p = 0.0197).

Conclusions
A single burr hole with irrigation and leaving a subdural drain is safe procedure in managing subdural hematoma. We did not experience major adverse events related to drain insertion and efficient evacuation of collection and no obvious increase in mortality or morbidity rates.
Digital orthopedics in the new AI era: from ASIA aspect
Authors: Wang Yan 
Published: December 2023

AbstractThis editorial explores the transformative impact of artificial intelligence (AI) on orthopedics, with a particular focus on advancements in Asia. It delves into the integration of AI in hospitals, advanced applications in China, and future expectations. The discussion is underpinned by an examination of AI's role in assisted diagnosis, treatment planning, surgical navigation, predictive analysis, and post-operative rehabilitation monitoring.
Banking sector development and environmental degradation in the Economic Community of West African States: do technology effects matter?
Authors: Prempeh Kwadwo Boateng , Yeboah Samuel Asuamah , Danso Felix Kwabena , Frimpong Joseph Magnus 
Published: December 2023

AbstractThis paper contributes to the discussion on environmental degradation by exploring the connection between banking sector development and environmental degradation in the ECOWAS. In addition, we investigate the direction of causation between environmental degradation and its drivers and the technological effect of banking sector development on environmental degradation. We rely on a balanced panel dataset of 11 ECOWAS nations from 1990 to 2019. We present the following conclusions using the AMG estimator and the Driscoll–Kraay panel regression model. First, banking sector development reduces environmental degradation. Second, banking sector development has a deleterious technological effect on environmental quality. Thirdly, population and affluence were found to significantly promote environmental degradation, while the impact of technology was inconclusive. We further demonstrate a unidirectional causation association between the development of the banking sector and environmental degradation using the Dumitrescu and Hurlin causality analysis. Based on the study conclusions, numerous policy ramifications have been suggested for the ECOWAS nations to mitigate environmental degradation.
Investigating Hessian-based inversion velocity analysis
Authors: Assis Carlos A. M. , Chauris Hervé , Audebert François , Williamson Paul 
Published: December 2023

Inversion velocity analysis (IVA) is an image-domain method built upon the spatial scale separation of the model. Accordingly, the IVA method is performed with an iterative process composed of two minimization steps consisting of migration (inner loop) and tomography (outer loop), respectively, with each step accounting for its Hessian or not. The migration part provides the common-image gathers (CIGs) with extension in the horizontal subsurface offset. Then, the differential semblance optimization (DSO) misfit measures the focusing of the events in the CIGs, which indicates the quality of the velocity model. Commonly, the velocity updates are obtained from the DSO gradient. IVA is a modified version in which the approximate inverse replaces the adjoint of the inner loop process; in that case, the migration Hessian is approximately diagonal in the high-frequency regime. In this work, we report on implementation of the tomographic Hessian (i.e., the second derivative of the DSO misfit with respect to the background model) for the estimation of the background velocity model. We apply the second-order adjoint-state method to obtain the application of the tomographic Hessian on a vector. Then, we use the truncated-Newton (TN) method to obtain the update directions by computing approximately the application of the inverse of the tomographic Hessian on the descent direction. We also make a theoretical comparison between tomography in the IVA and full-waveform inversion contexts. Two numerical examples are used to compare, in terms of geophysical results and computational costs, the TN method with different gradient-based optimization methods applied to the IVA. A small model allows us to evaluate the eigenvalues of the tomographic Hessian, which explains the large damping needed in the TN case.
Extraplanetary system under modified gravity
Authors: Alhejress Omaymah A. 
Published: December 2023

Abstract
We investigated the properties of exoplanets using a modified gravity law. We then devised a gravitational formula that linked the radius, mass, semimajor axis, and stellar mass of the exoplanet. This formula is then validated by taking into account four different astronomical organizations (WASP, HAT, TOI, and HATS). These findings are compared to those in the exoplanet.edu database. The findings corroborated the observational data. The Einstein curvature theory was created by incorporating planet spin into Newton's planet dynamics. As a result, the spin of the planet is connected to its gravity.