bluuebunny/crossref_metadata_2025_split huggingface dataset:
Time to Surgery Affects Wound Healing of Ankle Fractures
Authors: Guan Yuxi , Negron Nelson , Jiang Qiyun Jennifer , Park Janet J. , Kahn Mani , Kulsakdinun Chaiyaporn , Guo Yi 
Published: December 2023

Category: Trauma; Ankle Introduction/Purpose: Ankle fractures are very common. Most unstable ankle fractures require surgical intervention in order to obtain better clinical outcomes. However, there is still conflicting evidence about the implications of time to surgery on post- operative wound complications. Purpose of study: To investigate if early or delayed surgery results in difference in wound complications in patients who underwent surgical intervention for ankle fracture. Methods: A retrospective review of 238 ankle fracture cases treated with open reduction and internal fixation (ORIF) from October 28, 2016, through May 12, 2022 was completed at our institution. Patients were divided into 4 groups based on the time to surgery. In group 1, surgery was within a week. In group 2, surgery was in 2nd week. In group 3, surgery was in 3rd week. In group 4, surgery was after 3 weeks. Wound complications including minor wound complication and wound infection were investigated. The other factors including BMI, smoking, diabetes, etc. were investigated as well to avoid confounding bias. Since most of patients accepted surgery either in first 4 days (early surgery group) or between 10 to 20 days (delayed surgery group) in this series of patients. We also analyzed those two time points. Data was analyzed using STATA. Results: 238 patients with ankle fracture were analyzed. 36, 96, 71 and 35 patients were included in group 1, 2, 3 and 4 respectively. For BMI, smoking, and diabetes, no significant difference among 4 groups. The rate of minor wound complications in group 1, 2, 3 and 4 was 13.8%, 12.5%, 8.5% and 0%. The rate of wound infection in group 1, 2, 3 and 4 was 5.6%, 3.1%, 1.4% and 0%. For minor wound complication, there was significant decrease in group 4, as compared with group 1 and group 2 (p < 0.05). Interestingly, in term of early vs delayed surgery, both infection rate (13.3% vs 2.8%) and minor wound complication rate (33.3% vs 10.8%) significantly decreased in the delayed surgery group (p < 0.05). Conclusion: Delayed ORIF of ankle fracture resulted in decreased both minor wound complication rate and infection rate.
Tortuosity Angle of a Calcaneofibular Ligament on Magnetic Resonance Imaging & Stress Radiography
Authors: Kim Jin Su , Kim Sangbum 
Published: December 2023

Category: Ankle; Sports Introduction/Purpose: A lateral ankle sprain is one of the most common musculoskeletal injuries for both athletes and non- athletes, causing chronic ankle instability. Talar tilt angle on a radiograph used for diagnosis of chronic ankle instability(CAI), however, there were no reports of instability of calcaneofibular ligament(CFL) itself through an MRI. This study aimed to determine whether measuring tortuosity angles of CFL through oblique coronal imaging of MRI in CAI. We compared CFL’s tortuosity angle with the talar tilt angle, Cumberland ankle instability tool(CAIT), and ankle strength in patients without a history of ankle sprain or not. Methods: From March 2020 to May 2022, Of the total 120 cases, the CAI group (82 patients) took CFL’s tortuosity angle in MRI and talar tilt angle inradiograph. The control group (38 patients) included those without an ankle sprain who visited this hospital due to an Achilles tendon rupture. In the control group, the talar tilt angle could not be achieved due to pain. Results: CFL’s tortuosity angle in MRI showed a significant difference of 76.5 ± 18.3º in the CAI group and 31.9 ± 5.4º in the control group(P < 0.001). The diagnostic cutoff value for CAI was more than 40º of the tortuosity angle. According to the measure of the isokinetic machine(Biodex), the CAI group shows a 22.8% deficit of the eversion strength. The tortuosity angle, talar tilt angle, and manual stress test show significantly different between both groups. However, CAIT and strength defect showed no significant results between both groups. Conclusion: CFL’s tortuosity angle through oblique coronary imaging of MRI, it’s average value was 31º degrees, and we can diagnose as CAI if CFL’s tortuosity angle is more than 40º.
Trends in Utilization of Charcot Reconstruction
Authors: Newton William , Chen Caroline , Morningstar Joshua L. , Gross Christopher E. , Scott Daniel 
Published: December 2023

Category: Ankle; Diabetes Introduction/Purpose: Charcot arthropathy of the foot and ankle is a challenging complication of peripheral neuropathy with a 0.1% and 5.0% incidence in the diabetic population. The purpose of this study is to assess rates of foot or ankle reconstructions (fusions) for Charcot arthropathy, describe the associated patient demographics and hospital settings, and project the volume of Charcot reconstructions anticipated to be performed in 2030. Methods: The National Inpatient Sample database was queried from 2016-2019 using International Classification of Diseases (ICD) codes for foot or ankle fusion (midfoot, hindfoot, or ankle) and a diagnosis of Charcot arthropathy, ultimately identifying 1,343 patients undergoing surgical procedures. Patient information collected included age, sex, race, primary payer status, year of surgery, length of hospital stays, and median household income quartile. Hospital information included bed size, census region, teaching status, and ownership. Results: Between 2016-2019, there were approximately 1,343 patients treated surgically with midfoot, hindfoot, or ankle arthrodesis for Charcot arthropathy, and the number of cases increased by 12.11% annually. Between 2019-2030, there is projected to be a 121.41% increase in the frequency of Charcot reconstruction procedures from 383 to 848 total annual cases. Patients undergoing these procedures are predominantly white, male, and in their 50s. The most common payers were Medicare and private insurance. The mean hospital length of stay was 5.80 days. The procedures performed were predominantly large, urban teaching hospitals in the south with a private, non-profit ownership structure. Conclusion: Surgical reconstruction of Charcot arthropathy of the foot and ankle is steadily increasing in prevalence. These patients are predominantly white, male, and in their 50s. It is important for orthopaedic foot and ankle surgeons to be trained in the surgical management and reconstruction of Charcot arthropathy to meet the expected growing surgical need, which is projected to be 848 procedures annually by 2030.
Ultrasound Guided Cryoablation of Morton’s Neuroma: Case Series Including Post-Ablation MRI Appearances
Authors: Lam Kimberly , Lampridis Vasileios , Singh Anjani , Sirikonda Siva , Mistry Alpesh , Ghany Jehan F. , Chandrasekar Coonoor , Narang Yajur , Cusack James , Mason Lyndon W. 
Published: December 2023

Category: Midfoot/Forefoot; Other Introduction/Purpose: Morton’s neuroma (MN) is a very common compressive neuropathy of the interdigital nerve. Non- operative management is recommended initially and many therapies have been described. Cryoablation has shown promising results, however there are limited published studies in the literature. The purpose of this study was to assess the safety and efficacy of Cryoablation in patients with MN. A secondary aim was to evaluate post-procedure MRI appearances. Methods: A retrospective analysis was completed for 24 MN treated between June 2021 and September 2022. All patients had refractory MN symptoms after previous US guided steroid and LA injection within the previous year. Three patients also had refractory symptoms after prior alcohol ablation. Cryoablation was performed as a single outpatient procedure under continuous US monitoring and local anesthesia with 1 cycle for average of 2 minutes. Telephone follow up by radiology department with a 0–10 visual analogue scale (VAS) score was performed at 6 weeks and 3 months post-ablation. The patients were also encouraged to submit patient reported outcomes to a British Foot and Ankle Society (BOFAS) online scoring database as facilitated by the surgical team. Post-ablation MRI was performed to evaluate for post-procedure appearances at various intervals between 3 to 14 months. Results: 24 MN were treated. The mean size of MN treated was 12.3mm. Technical success was 100% and all patients tolerated the procedure well under local anesthesia. Mean pre-procedure VAS pain score was 8, which reduced to 1 at 6 weeks, and 2 at 3 months follow up in the treated MN. There is high patient satisfaction with 20 cases (83%) very satisfied. Four cases had various persistent symptoms and would want to have it done again (17%). Post-ablation MRI showed various bone and soft tissue changes in the ablation zone. There were two cases of fibrosis in the intermetatarsal space and one residual neuroma observed on MRI, although the patients were asymptomatic in the ablation site. No complications occurred e.g. infection, fracture or thermal injury. Conclusion: In this small series, ultrasound guided Cryoablation was deemed safe and effective treatment for MN. Clinical advantages of the procedure are good patient tolerance, single outpatient procedure, high patient satisfaction and reduced risk of scarring or residual neuroma. Further controlled prospective studies would be beneficial.
Validity of the Center-Center Method for Syndesmotic Fixation Axis Against the Trans-Syndesmotic Axis: A Cross-Sectional Study
Authors: Nakajima Hirofumi , Yamaguchi Satoshi , Mikami Yukio , Kimura Seiji 
Published: December 2023

Category: Trauma; Ankle Introduction/Purpose: In surgery for ankle fractures with tibiofibular diastasis, it is important to vertically grasp the distal tibiofibular joint. However, it is difficult to do that because the tibiofibular joint surface is not under direct vision. Center-center method (CC) is an intraoperative fluoroscopic technique to determine the position of the syndesmotic clamp. CC has been reported to reduce the risk of syndesmotic malreduction, but It is unclear whether the axis by CC (CC axis) coincides with the axis perpendicular to the distal tibiofibular joint (trans-syndesmosis axis: TS axis). Therefore, the present study aims to 1) measure the difference between the CC axis and TS axis, and 2) compare the measured values when CC is performed at different distances from the ankle joint surface. Methods: The subjects were 150 patients who underwent CT scans for ankle joint disease and lower extremity trauma. CC is a method in which the ankle joint is rotated, and the midpoint of the anteroposterior margin of the tibia and fibula is superimposed by fluoroscopy. In the present study, CC was performed using Digitally reconstructed radiography (DRR) created from a CT image. At the ankle joint surface (0mm), CC axis and TS axis were projected onto the CT axis linked with DRR. The angle between the axes was measured (inter-axes angle). Also, the distance of the intersection of these axes through the medial cortex of the tibia was measured (inter-axes distance). It was also performed at 10mm and 20mm proximal to the ankle joint surface. One-way repeated measures analysis of variance and the post hoc Bonferroni tests were used to compare the measured values' difference according to the articular surface's height. Results: Overall, the TS axis was externally rotated relative to the CC axis, with a mean inter-axes angle of 8.5±6.8degrees. The inter-axes angle of 0mm, 10mm, and 20mm were 1.9±4.0degrees, 10±5.3degrees, and 13±5.1degrees, respectively (p < 0.001). Also, the intersection point of the TS axis with the medial tibial cortex was anterior to the intersection of the CC axis, with an inter-axes distance of 7.7±6.3mm overall. The inter-axes distance of 0mm, 10mm, and 20mm were 2.0±4.2mm, 9.0±4.9mm, and 11.3±5.2mm, respectively (p < 0.001). Both the inter-axes angle and the inter-axes distance were larger when the CC method was performed higher to the tibial plafond (P < .001), with the post hoc tests showing significant differences among all heights. Conclusion: The TS axis was externally rotated to the CC axis and positioned slightly anteriorly. Also, the inter-axes angle and distance were larger when the CC method was performed higher to the tibial plafond. If the surgeon aimed to clamp the syndesmosis along the TS axis, the CC method should be applied closer to the ankle joint surface, and the medial tip of the forceps be placed slightly anterior to the point determined by the CC axis.
Weight-bearing CT Scan Analysis in Hallux Valgus Treated with Minimally Invasive Surgery
Authors: Ahumada Ximena , Protasowicki Nicolas , Pellegrini Manuel J. , Carcuro Giovanni , Chaparro Felipe , Ortiz Cristian A. 
Published: December 2023

Category: Bunion; Midfoot/Forefoot Introduction/Purpose: Hallux valgus (HV) is one of the most prevalent foot deformities. Coronal metatarsal rotation (pronation) has been recognized as a key element in HV deformity and an important prognostic factor for recurrence. With the advent of weight-bearing CT (WBCT), accurate pronation measurement has improved. The Minimally Invasive Bosh Akin (MIBA) surgery has proven to be effective in treating HV deformity. The literature analyzing correction of pronation in HV surgery is lacking. Purpose: To compare the transverse and coronal plane deformity correction by WBCT in HV patients treated with MIBA surgery. Methods: We retrospectively analyzed HV deformity in patients who underwent MIBA surgery with preoperative and at least 3 months postoperative WBCT for comparison. Intermetatarsal angle (IMA), hallux valgus angle (HVA), and alpha angle (AA) for first metatarsal pronation were measured by 2 different observers. The intraclass and interclass correlation were determined. Pre and postoperative measurement changes were established by T-test for related samples. the p-value for statistical significance was set at < 0.05. Results: 37 feet were included. Intraclass correlation was 0.97 /0.92 for IMA; 0.95/0.91 for AA and 0.99/0.97 for HVA preoperative. Postop it was 0.97/ 0.96 for IMA, 0.97/0.92 for AA, and 0.98 and 0.96 for HVA. Interclass correlation was 0.95 for IMA; 0.7 for AA and 0.82 for HVA preoperative. Postop, was 0.82 for IMA, 0.8 for AA, and 0.79 for HVA. Mean preoperative / postoperative AA was 8.9 degrees and 6.9 degrees respectively, resulting in a first ray pronation change of –2.0 degrees, p< 0.054. The media preoperative and postoperative IMA was 13.6 degrees and 6.8 degrees, demonstrating a significant change (P < .005). The media preoperative and postoperative HVA was 28.7 (8.8) and 13.1 (9.0), demonstrating a significant change (P < .005). Conclusion: To the best of our knowledge, this is the first study that evaluates the radiological changes in HV surgery with WBCT. The MIBA osteotomy for HV deformity has significant power to correct the transverse plane deformity. Even though the coronal plane deformity correction wasn’t statistically significant, it showed a strong tendency, which might be demonstrated by utilizing a bigger sample. The only measurement that didn’t have an excellent agreement was the preop AA.
Zone 2 5th Metatarsal Fractures Treated Nonoperatively Have Similar Time to Healing to Those Treated Operatively
Authors: Kingery Matthew T. , Kadiyala Manasa , Walls Raymond J. , Ganta Abhishek , Konda Sanjit , Egol Kenneth A. 
Published: December 2023

Category: Midfoot/Forefoot; Trauma Introduction/Purpose: The purpose of this study was to quantify the time to clinical and radiographic healing in Zone 2 proximal 5th metatarsal (MT) fractures and to compare these outcomes to those of Zone 2 fractures treated operatively. Methods: A retrospective cohort study of all Zone 2 metatarsal fractures seen at a single large, urban, academic medical center between December 2012 and April 2022 was performed. Zone 2 injuries were defined as fractures entering the proximal 4-5 MT articulation on the oblique radiographic view. Clinical healing was characterized by the return to baseline ambulatory function without discomfort and a lack of tenderness on physical examination. Radiographic healing was defined as complete osseous consolidation. A total of 374 patients with Zone 2 proximal 5th MT fractures were included in the analysis. The mean age of patients was 53.8 +/- 16.6 years, and 74.3% were female. Results: 93.3% of patients with Zone 2 metatarsal fractures were treated nonoperatively. In the nonoperative group, 6.6% experienced delayed bony union with incomplete radiographic healing after 6 months, compared to 16.0% of the operative group (p = 0.095). However, by 1 year post-injury, 98.9% of patients who underwent nonoperative management and 96.0% of operative patients demonstrated radiographic union. Two patients failed nonoperative management and underwent operative fixation for symptomatic nonunions. There was no difference in time to radiographic healing between patients treated nonoperatively and those treated operatively (4.4 +/- 2.8 months vs 5.4 +/- 4.7 months, p = 0.413). Similarly, there was no difference in time to clinical healing between both groups (2.3 +/- 1.9 months vs 2.6 +/- 3.8 months, p = 0.723). Conclusion: Zone 2 5th metatarsal base fractures, which are often incorrectly referred to as Jones fractures despite being proximal to the fractures originally characterized by Jones, can be successfully treated with nonoperative management. There is no evidence that operative treatment leads to significantly faster clinical or radiographic healing for patients.
Utilising high-dimensional data in randomised clinical trials: A review of methods and practice
Authors: Cherlin Svetlana , Bigirumurame Theophile , Grayling Michael J , Nsengimana Jérémie , Ouma Luke , Santaolalla Aida , Wan Fang , Williamson S Faye , Wason James MS 
Published: December 2023

Introduction Even in effectively conducted randomised trials, the probability of a successful study remains relatively low. With recent advances in the next-generation sequencing technologies, there is a rapidly growing number of high-dimensional data, including genetic, molecular and phenotypic information, that have improved our understanding of driver genes, drug targets, and drug mechanisms of action. The leveraging of high-dimensional data holds promise for increased success of clinical trials. Methods We provide an overview of methods for utilising high-dimensional data in clinical trials. We also investigate the use of these methods in practice through a review of recently published randomised clinical trials that utilise high-dimensional genetic data. The review includes articles that were published between 2019 and 2021, identified through the PubMed database. Results Out of 174 screened articles, 100 (57.5%) were randomised clinical trials that collected high-dimensional data. The most common clinical area was oncology (30%), followed by chronic diseases (28%), nutrition and ageing (18%) and cardiovascular diseases (7%). The most common types of data analysed were gene expression data (70%), followed by DNA data (21%). The most common method of analysis (36.3%) was univariable analysis. Articles that described multivariable analyses used standard statistical methods. Most of the clinical trials had two arms. Discussion New methodological approaches are required for more efficient analysis of the increasing amount of high-dimensional data collected in randomised clinical trials. We highlight the limitations and barriers to the current use of high-dimensional data in trials, and suggest potential avenues for improvement and future work.
Should continuous deep sedation until death be legally regulated in Switzerland? An exploratory study with palliative care physicians
Authors: Tomczyk Martyna , Andorno Roberto , Jox Ralf J. 
Published: December 2023

Background: In Switzerland, continuous deep sedation until death (CDSUD) is not legally regulated and the current clinical practice guidelines on palliative sedation from 2005 do not refer to it. In contrast, in France, a neighbouring country, CDSUD is regulated by a specific law and professional guidelines. International studies show that in culturally polymorphic countries, there are variations in the end-of-life practices between linguistic regions and that a linguistic region shares many cultural characteristics with the neighbouring country. Objectives: This study aimed to explore the attitudes of palliative care physicians from the French-speaking part of Switzerland on the question of whether CDSUD should be legally regulated in the country, and to identify their arguments. Our study also aimed to assess whether a hypothetical Swiss law on CDSUD should be similar to the current legal regulation of this practice in France. Design: We conducted a multicentre exploratory qualitative study based on face-to-face interviews with palliative care physicians in the French-speaking part of Switzerland. Methods: We analysed the interview transcripts using thematic analysis, combining deductive and inductive coding. Results: Most of the participants were opposed to having specific legal regulation of CDSUD in Switzerland. Their arguments were diverse: some focused on medical and epistemological aspects of CDSUD, whereas others emphasized the legal inconvenience of having such regulation. None had the opinion that, if CDSUD were legally regulated in Switzerland, the regulation should be similar to that in France. Conclusion: This study allows to better understand why palliative care physicians in French-speaking Switzerland may be reluctant to have legal regulation of CDSUD. Further studies covering the whole country would be needed to gain a more complete picture of Swiss palliative care physicians on this question.
Yoga Plus Mantram Repetition to Reduce Chronic Pain in Veterans With Post-Traumatic Stress Disorder: A Feasibility Trial
Authors: Groessl Erik J. , Hafey Carol , McCarthy Adhana , Hernandez Rahil M. , Prado-Nava Miguel , Casteel Danielle , McKinnon Symone , Chang Douglas G. , Ayers Catherine R. , Rutledge Thomas R. , Lang Ariel J. , Bormann Jill E. 
Published: December 2023

Background Veterans with post-traumatic stress disorder (PTSD) are more likely to report chronic pain than veterans without PTSD. Yoga has been shown to reduce both chronic pain and PTSD symptoms in clinical trials. The goal of our study was to assess the feasibility and acceptability of conducting a randomized controlled trial (RCT) that combined yoga and mantram repetition (Yoga + MR) into one program for military veterans with both chronic pain and PTSD. Methods In this feasibility RCT, 27 veterans were randomized to either Yoga + MR or a relaxation intervention. Due to the COVID-19 pandemic, in-person recruitment, assessments, and intervention attendance were re-evaluated. Although remote delivery of aspects of the study were utilized, interventions were delivered in-person. Feasibility benchmarks met included full recruitment in 12 months or less, 75%+ retention at initial follow-up assessment, 50%+ attendance rate, and 75%+ of participants satisfied with the interventions. Results The sample was racially and ethnically diverse, and 15% of participants were women. Participant recruitment lasted approximately 11 months. Out of 32 participants initially randomized, two participants asked to be dropped from the study and three did not meet PTSD symptom criteria. For the remaining 27 participants, retention rates were 85% at 12 weeks and 81% at 18 weeks. Participants attended 66% of in-person yoga and 55% of in-person relaxation sessions. Satisfaction was high, with 100% of yoga participants and 75%/88% of relaxation participants agreeing or strongly agreeing they were satisfied with the intervention/instructors. After 12 weeks (end of intervention), Yoga + MR participants reported reduced back-pain related disability (primary outcome), reduced alcohol use, reduced fatigue, and increased quality of life, while relaxation group participants reported reductions in pain severity, PTSD symptoms, and fatigue. Conclusions Amidst many research challenges during the pandemic, recruitment, retention, and efficacy results from this feasibility trial support advancement to a larger RCT to study Yoga + MR for chronic pain and PTSD.