bluuebunny/crossref_metadata_2025_split huggingface dataset:
Promotive and preventive interventions for adolescent mental health in Sub-Saharan Africa: a combined scoping and systematic review
Authors: Seekles Maaike , Twagira Fantacy , Alam Ali , Obasi Angela 
Published: December 2023

IntroductionPoor mental health in adolescence is associated with mental, physical and social problems in later life. Adolescence is, therefore, a critical time for promoting mental well-being and preventing mental illness, particularly in sub-Saharan Africa, where adolescents are exposed to a multitude of risk factors for poor mental health. This review aimed to map the current use, effectiveness and cultural sensitivity of promotive/preventive adolescent mental health interventions in the region.MethodsA combined scoping and systematic review was conducted using the Arksey and O’Malley framework through searches in MEDLINE, CINAHL, Global Health, PsycINFO and the Cochrane Database of Systematic Reviews, covering January 2000 to December 2021.ResultsThis review identified 79 papers, related to 61 unique interventions. Only five universal, school-based programmes were identified; most studies targeted orphans or HIV positive adolescents. Psychosocial interventions—aimed at strengthening knowledge, expression and psychosocial skills—produced mixed results. Structural interventions were often community-based and had limited psychosocial programming. Those that focused on HIV prevention, gender equity and parenting also produced mixed results; evidence was strongest for economic-livelihood programmes. Few studies described cultural sensitivity in detail. Some explained how the intervention aligned with local worldviews/values; had context-specific content; were based on explorations of relevant concepts; or integrated spiritual/cultural practices.ConclusionPreventive/promotive interventions for adolescent mental health in sub-Saharan Africa are limited in terms of geographical spread, but broad in terms of intervention types. Targeted approaches reflect realities that adolescents in the region face in relation to socioeconomic deprivation, family disruption and poor physical health. Yet, universal interventions that focus on general well-being are limited and lack a consideration of contemporary developments in the region such as increased social media use, suicide and obesity. Economic livelihood interventions showed most consistent evidence of effectiveness. Future studies could do more to consider/report cultural sensitivity.
Shrink & Morph: 3D-Printed Self-Shaping Shells Actuated by a Shape Memory Effect
Authors: Jourdan David , Hugron Pierre-Alexandre , Schreck Camille , Martínez Jonàs , Lefebvre Sylvain 
Published: December 2023

While 3D printing enables the customization and home fabrication of a wide range of shapes, fabricating freeform thin-shells remains challenging. As layers misalign with the curvature, they incur structural deficiencies, while the curved shells require large support structures, typically using more material than the part itself.
We present a computational framework for optimizing the internal structure of 3D printed plates such that they morph into a desired freeform shell when heated. This exploits the shrinkage effect of thermoplastics such as PLA, which store internal stresses along the deposition directions. These stresses get released when the material is heated again above its glass transition temperature, causing an anisotropic deformation that induces curvature.
Our inverse design method takes as input a freeform surface and finds an optimized set of deposition trajectories in each layer such that their anisotropic shrinkage deforms the plate into the prescribed surface geometry. We optimize for a continuous vector field that varies across the plate and within its thickness. The algorithm then extracts a set of deposition trajectories from the vector field in order to fabricate the flat plates on standard FFF printers. We validate our algorithm on freeform, doubly-curved surfaces.
Voltammetric Analysis of Thiram with Bimetallic Nanosensor and Investigation of Adsorption Mechanism by DFT-D3 Method
Authors: Celik Murat , Kanbes-Dindar Cigdem , Karayel Arzu , Bozal-Palabiyik Burcin , Uslu Bengi 
Published: December 2023

In this study, to detect thiram electrochemically, a simple nanosensor based on a glassy carbon electrode (GCE) modified with green-synthesized Ag and Au nanoparticles was designed. AuNPs@AgNPs/GCE nanosensor gave considerably greater signal for 5 ppm thiram in pH 3.0 phosphate buffer solution using adsorptive stripping differential pulse voltammetry compared to bare GCE. Under ideal conditions, the nanosensor produced a linear concentration calibration curve extending from 0.2 to 1.4 ppm for thiram, with limits of detection and quantification of 0.033 ppm and 0.100 ppm, respectively. The developed electrochemical bimetallic nanosensor demonstrated high sensitivity and stability, showing that it is a novel and promising platform for thiram determination. Furthermore, the nanosensor was used to assess thiram in human serum and recovery was obtained as 103.6%. DFT-D3 results showed that covalent modification of GCE with AuNPs/AgNPs occurs with the electron transfer between the electrode surface and thiram by bonding sulfur atoms of thiram to AgNPs and AuNPs. Both experimental and theoretical analyses showed that the modification with Ag and Au, GCE appeared to be a key property to improve the electronic activity at the surface and increase the charge transfer that facilitates the adsorption of the selected guest.
Genetic Factors and Long-term Treatment-Related Neurocognitive Deficits, Anxiety, and Depression in Childhood Leukemia Survivors: An Exome-Wide Association Study
Authors: Petrykey Kateryna , Lippé Sarah , Sultan Serge , Robaey Philippe , Drouin Simon , Affret-Bertout Laurence , Beaulieu Patrick , St-Onge Pascal , Baedke Jessica L. , Yasui Yutaka , Hudson Melissa M. , Laverdière Caroline , Sinnett Daniel , Krajinovic Maja 
Published: December 2023

Abstract

Background:
An increased risk of neurocognitive deficits, anxiety, and depression has been reported in childhood cancer survivors.

Methods:
We analyzed associations of neurocognitive deficits, as well as anxiety and depression, with common and rare genetic variants derived from whole-exome sequencing data of acute lymphoblastic leukemia (ALL) survivors from the PETALE cohort. In addition, significant associations were assessed using stratified and multivariable analyses. Next, top-ranking common associations were analyzed in an independent SJLIFE replication cohort of ALL survivors.

Results:
Significant associations were identified in the entire discovery cohort (N = 229) between the AK8 gene and changes in neurocognitive function, whereas PTPRZ1, MUC16, TNRC6C-AS1 were associated with anxiety. Following stratification according to sex, the ZNF382 gene was linked to a neurocognitive deficit in males, whereas APOL2 and C6orf165 were associated with anxiety and EXO5 with depression. Following stratification according to prognostic risk groups, the modulatory effect of rare variants on depression was additionally found in the CYP2W1 and PCMTD1 genes. In the replication SJLIFE cohort (N = 688), the male-specific association in the ZNF382 gene was not significant; however, a P value&lt;0.05 was observed when the entire SJLIFE cohort was analyzed. ZNF382 was significant in males in the combined cohorts as shown by meta-analyses as well as the depression-associated gene EXO5.

Conclusions:
Further research is needed to confirm whether the current findings, along with other known risk factors, may be valuable in identifying patients at increased risk of these long-term complications.

Impact:
Our results suggest that specific genes may be related to increased neuropsychological consequences.
A Phase Ib Study of the DNA-PK Inhibitor Peposertib Combined with Neoadjuvant Chemoradiation in Patients with Locally Advanced Rectal Cancer
Authors: Romesser Paul B. , Capdevila Jaume , Garcia-Carbonero Rocio , Philip Tony , Fernandez Martos Carlos , Tuli Richard , Rodriguez-Gutierrez Almudena , Kuipers Mirjam , Becker Andreas , Coenen-Stass Anna , Sarholz Barbara , You Xiaoli , Miller Eric D. 
Published: December 2023

Abstract

Purpose:
Peposertib—an orally administered DNA-dependent protein kinase inhibitor—has shown potent radiosensitization in preclinical models. This dose-escalation study (NCT03770689) aimed to define the maximum tolerated dose (MTD) and recommended phase II dose (RP2D) of peposertib plus capecitabine-based chemoradiotherapy (CRT) and assessed its safety and efficacy in locally advanced rectal cancer.

Patients and Methods:
Patients were treated for 5 to 5.5 weeks with 50- to 250-mg peposertib once daily, capecitabine 825 mg/m2 twice daily, and radiotherapy (RT), 5 days per week. Following clinical restaging (8 weeks after CRT completion), patients with clinical complete response (cCR) could opt for surveillance. Total mesorectal excision was recommended upon incomplete response (IR).

Results:
Nineteen patients were treated with peposertib at doses of 50 mg (n = 1), 100 mg, 150 mg, and 250 mg (n = 6 each). Dose-limiting toxicities occurred in one out of five (100 mg), one out of six (150 mg), and three out of six (250 mg) evaluable patients. Peposertib ≤150 mg once daily was tolerable in combination with CRT. After 8 weeks of treatment with peposertib and CRT, the cCR was 15.8% (n = 3). Among the three patients with cCR, two underwent surgery and had residual tumors. Among the 16 patients with IR, seven underwent surgery and had residual tumors; five of the remaining nine patients opted for consolidative chemotherapy. The combined cCR/pathologic complete response (pCR) rate was 5.3% (n = 1, 100 mg cohort).

Conclusions:
Peposertib did not improve complete response rates at tolerable dose levels. The study was closed without declaring the MTD/RP2D.
Spousal Harm in the Mālikī Law School: Evidence and Procedure
Authors: Alkiek Tesneem 
Published: December 2023

Abstract
The Mālikī law school grants a wife the right to judicial divorce if her husband harms her. Mālikīs distinguish between harm that is legally actionable and harm that is non-actionable. A husband causes actionable harm (ḍarar) when he violates his wife’s rights, which Mālikī scholars define broadly. By establishing ḍarar as grounds for divorce, Mālikīs demonstrate their willingness to limit a husband’s marital authority and increase opportunities for a woman to leave her marriage. In this study, I highlight the types of evidence and procedures Mālikī jurists use to establish ḍarar and facilitate judicial divorce by examining four cases that deal with emotional, sexual, and physical harm. Through a substantive approach to law, Mālikīs offer several ways for a woman to collect evidence, prove her claim of harm, and receive a divorce.
Fossil woods from Corcovado (Eocene?), Argentinean Patagonia: angiosperm diversity and biodeterioration
Authors: Pujana Roberto R. , García Massini Juan L. , Noetinger Sol , Aramendía Inés 
Published: December 2023

Summary
Angiosperm fossil woods of putative Eocene age from Corcovado, Chubut Province are described. They are placed in four taxonomic units: Weinmannioxylon trichospermoides and cf. Caldcluvioxylon of the Cunoniaceae, Myrceugenellites maytenoides of the Myrtaceae, and Nothofagoxylon ruei of the Nothofagaceae. The taxa in the assemblage are in accordance with similar fossil wood assemblages previously described from the Eocene and Oligocene of Patagonia. All the taxa are anatomically similar to trees that live today in Patagonia. Some of the woods show decay patterns by different saproxylic organisms. These include arthropod borings with coprolites and fungal remains in fungi-decayed tissues that are consistent with an active saproxylic community involved in the recycling of wood in the depositional paleoenvironment.
Type-O Blood Is Not Associated With Elevated Mortality After Trauma: A North American Cohort Study
Authors: Kwasny Lauren , Adams Meredith , Bovio Nicholas , Rahaman Zakiur , VandenBerg Sheri , Markle Stephanie , Bjerke Scott , Shebrain Saad , Sawyer Robert 
Published: December 2023

Background Recent studies have presented contradictory findings on the relationship between blood type and mortality in trauma patients. Using the largest population in a study of this type to date, we hypothesized that ABO genotype and Rhesus status would influence trauma-related mortality and morbidity given the relationship between blood type and hemostasis. Methods Data from all trauma patients admitted to level I and level II trauma centers in one city over a five-year period was retrospectively analyzed. Patients were stratified by ABO type. Patient demographics and outcomes were then assessed. Chi-squared and Fisher’s exact tests were used to analyze categorical variables. Continuous variables were analyzed using ANOVA or Kruskal-Wallis tests as appropriate. Logistic regression was used to determine independent associations for 28-day mortality and complications. Results Of 5249 patients, severe injury (ISS >15) was present in 1469. Approximately one-quarter of patients with severe injury received blood products within the first 24 hours. There were no significant variations in demographics or complications between patients of different blood types. Univariate and multivariable regression analysis showed no association between blood type and mortality. However, penetrating injury, lower GCS, higher ISS, blood transfusion within 24 hours, and Asian descent were associated with higher overall mortality. Conclusions In contrast to previous studies, we found no evidence of an association between blood type and mortality. However, our findings suggest that patients of Asian descent may be at higher risk for mortality following trauma. Further research is warranted to explore this observation.
Post Take-Over Performance Varies in Drivers of Automated and Connected Vehicle Technology in Near-Miss Scenarios
Authors: Yamani Yusuke , Glassman Jeffrey , Alruwaili Abdalziz , Yahoodik Sarah E. , Davis Emily , Lugo Samantha , Xie Kun , Ishak Sherif 
Published: December 2023

Objective This study examined the impact of monitoring instructions when using an automated driving system (ADS) and road obstructions on post take-over performance in near-miss scenarios. Background Past research indicates partial ADS reduces the driver’s situation awareness and degrades post take-over performance. Connected vehicle technology may alert drivers to impending hazards in time to safely avoid near-miss events. Method Forty-eight licensed drivers using ADS were randomly assigned to either the active driving or passive driving condition. Participants navigated eight scenarios with or without a visual obstruction in a distributed driving simulator. The experimenter drove the other simulated vehicle to manually cause near-miss events. Participants’ mean longitudinal velocity, standard deviation of longitudinal velocity, and mean longitudinal acceleration were measured. Results Participants in passive ADS group showed greater, and more variable, deceleration rates than those in the active ADS group. Despite a reliable audiovisual warning, participants failed to slow down in the red-light running scenario when the conflict vehicle was occluded. Participant’s trust in the automated driving system did not vary between the beginning and end of the experiment. Conclusion Drivers interacting with ADS in a passive manner may continue to show increased and more variable deceleration rates in near-miss scenarios even with reliable connected vehicle technology. Future research may focus on interactive effects of automated and connected driving technologies on drivers’ ability to anticipate and safely navigate near-miss scenarios. Application Designers of automated and connected vehicle technologies may consider different timing and types of cues to inform the drivers of imminent hazard in high-risk scenarios for near-miss events.
Successful implementation of prophylactic veno-venoarterial extracorporeal membrane oxygenation in high-risk trauma surgery: A case report
Authors: Chico Juan I , Gomez Vanesa , Freita Santiago , Rivas María D , Mosquera David , Menor Eva M , Piñon Miguel A 
Published: December 2023

Introduction Extracorporeal Membrane Oxygenation (ECMO) is increasingly utilized in trauma care, yet its elective use during high-risk surgeries remains unreported. Case Report We report a successful instance of prophylactic ECMO support via a Veno-Venoarterial (V-VA) configuration during high-risk surgery in a patient with extensive trauma, including severe thoracic damage and a highly unstable thoracic spine fracture. V-VA ECMO prevented complications such as hemodynamic and respiratory collapse associated with chest compression during the surgical procedure, as the patient should be in a prone position. Discussion The potential of ECMO as prophylactic support in high-risk surgery amongst trauma patients underscores a novel application of this technology. Complex configurations must be evaluated to avoid associated ECMO complications. Conclusion Our case highlights the potential of prophylactic ECMO hybrid modes, indicating their safe application during high-risk procedures in select trauma patients.
“Be Serious!”: In Memoriam Herb Gintis
Authors: Jayadev Arjun , Naidu Suresh 
Published: December 2023

Herb Gintis, who left us in 2023, was a giant of left economics. He believed passionately in ideas and their power, especially in helping deliver a more just and desirable world. In a career spanning six decades, he asked the most profound questions about economics and its aims and possibilities, and inspired a generation of economists in turn. We here recount his work and our interactions with him. JEL Classification: A11, P00
Anti-convulsant Effects of Scutellarein in a PTZ Kindling Model in Mice
Authors: Duan Jun , Wang Jiao , Zhao Qian , Wu Dean , Liu Yang 
Published: December 2023

Background: Epilepsy is a chronic neurological condition with various underlying mechanisms. It is known to affect a multitude of people across the globe, regardless of age and gender. Seizures associated with epilepsy involve the participation of stimulatory glutamatergic mechanisms along with inflammation and oxidative damage. Objectives: In this investigation, the anti-epileptic effect of scutellarein, a phytochemical compound isolated from Erigeron breviscapus (Vant.), has been evaluated in the pentylenetetrazol (PTZ) kindling epilepsy model in mice. Materials and Methods: The experimental mice were categorized into six groups with six animals in each. The first control group was given normal saline. The second group was provided only PTZ through an intraperitoneal route to induce seizures. The third and fourth groups received two oral doses of scutellarein (10 and 20 mg/kg) before 30 min of PTZ induction. Diazepam was intraperitoneally administered to the fifth group as a positive control. The impact of scutellarein on the duration and initiation of clonic and tonic convulsion, mortality, kindling, mobility, and immobility duration in PTZ-induced rodents was estimated. Also, the impact of scutellarein on oxidative stress markers and antioxidant and inflammatory marker levels was also evaluated. Results: Scutellarein treatment was able to reduce PTZ-induced seizures in mice. In PTZ animals, scutellarein lowered the seizure severity by suppressing the onset and duration of convulsions. Scutellarein successfully modulated the PTZ-provoked changes in gamma-aminobutyric acid (GABA), glutamate, and dopamine levels, as well as Ca2+ ATPase and Na+ K+ ATPase activity. Conclusion: Furthermore, it remarkably reduced the oxidative stress markers and decreased the contents of nuclear factor-kappa B (NF-κB), tumor necrosis factor-α (TNF-α), and interleukin-1β (IL-1β) in PTZ animal brain tissues, confirming its anti-convulsant potential.
Research on the crossing obstacle ability of wheeled vehicle on soft beach ground
Authors: Liu Yanchen , Huang Xuetao 
Published: December 2023

Given the crossing-obstacle problems of wheeled vehicle on soft beaches, the changing rules with driving speeds of the crossing-obstacle ability of wheeled vehicle, soil moisture content, and soil type on soft beach ground were innovatively studied in this paper, with the hook traction force taken as the evaluating index. It showed that the RMS values of wheeled vehicle hook traction force, which was 9484N at 5 km/h and 8859N at 20 km/h, decreased with the increase in driving speed when the wheeled vehicle crossed the horizontal ditch. It collected soft beach ground soil samples and tested the parameters of mechanical properties. By considering specific structural parameters of the wheeled vehicle, this paper constructed the simulating model of the crossing obstacle ability of wheeled vehicle on the soft beach, analyzed the differences between the simulation and test result through full-scale vehicle tests. It discussed the influential factors of the crossing obstacle ability of wheeled vehicle on soft beach ground, indicated that the crossing obstacle ability of wheeled vehicle on soft beach increased with the increase of equipment’s driving speed and soil moisture content. This paper creatively proposed a method to evaluate the equipment’s off-road trafficability based on the combination of soil in-situ collection, soil tank test, dynamic simulation and experimental verification, and proposed the influencing factors and changing rules of equipment’s off-road trafficability on soft beach ground, which laid a theoretical foundation for the research on the off-road trafficability of wheeled vehicle.
Sustainable mindsets: Combining traditional indigenous knowledge with non-aboriginal understanding to address environmental risks
Authors: Oliver Rhonda , Sheffield Rachel , Bradshaw Ronita , Hunter Jacqui , Nowers Sarah , Taylor-Ellison Briana 
Published: December 2023

Aboriginal and Torres Strait Islander peoples are the traditional owners of Australia. It has been predicted that they have been the custodians of these lands for at least 60,000 years. Their traditional lands are inextricably linked to their languages, cultural practices and spiritual being. As the custodians they have used their traditional Indigenous knowledge to care for the land – its plants, animals and waterways, protecting unique ecosystems and maintaining sustainability. In fact, their traditional understanding reflects what has been described in the literature as a sustainable mindset. We come together as non-Aboriginal and Aboriginal educators to explore how environmental threats within the epoc of Anthropocene may be addressed using such a sustainable mindset – one reflecting both indigeneity and posthumanism perspectives. We describe three case studies showing how the use of traditional knowledge held by local Indigenous communities (IPLCs) can be used with non-Indigenous knowledge to address human induced planetary changes to protect important animal species and the land on which they live. We draw on written and oral reports from our Indigenous co-authors and data obtained informally from them by way of ‘yarning’. We describe how in the north-west of Western Australia areas of significant ecological and cultural value are being negatively affected by human-induced change threatening different animal species and ecosystems. We outline the effects of light pollution in Port Hedland and how this is disrupting the life cycle of the flatback sea turtle - culturally significant sea animals. As a point of comparison, we next describe how green back turtle and Dugong populations are being protected and sustained on the Dampier Peninsula using traditional knowledge more recently supplemented through the work of the Bardi Jawi Rangers. Finally, we examine how the Fitzroy River catchment area is increasingly under threat from water extraction and mining, but how a sustainable mindset can be used to obviate these environmental risks.