bluuebunny/crossref_metadata_2025_split huggingface dataset:
Intraoceanic Subduction System Within the Neo‐Tethys: Evidence From Late Cretaceous Arc Magmatic Rocks of the Eastern Himalaya
Authors: Zhang Zeming , An Wentao , Palin Richard M. , Ding Huixia , Dong Xin , Tian Zuolin 
Published: December 2023

AbstractThe tectonic evolution of the Neo‐Tethys Ocean remains highly controversial, with several models existing in the community that conflict with each other. Here, we present new geochronologic and geochemical data for orthogneisses and amphibolites from the Greater Himalayan Sequence, eastern Himalayan orogen, which indicate that these rocks have Cenozoic metamorphic ages (∼52–3 Ma), but were derived from Late Cretaceous (∼89 Ma) magmas with arc‐like and depleted mantle geochemical signatures. Considering that northern India was a passive continental margin during the Mesozoic, and the previously reported Late Cretaceous magmatic rocks in the eastern Himalaya formed in a continental rifting setting, we suggest that the studied Late Cretaceous arc‐type magmatic rocks formed in an intraoceanic arc setting within the Neo‐Tethys, and accreted onto the passive margin of the Indian continent prior to the terminal continental collision. When combined with the existence of Late Mesozoic and intraoceanic arc‐type magmatic rocks in the western Himalaya, we suggest that a huge Late Cretaceous subduction system operated within the eastern Neo‐Tethys Ocean. This study supports two subduction zones having been responsible for the consumption and closure of the Neo‐Tethys basin, and a two‐stage collision history between India, Asia, and the intermediate island arc system. Our data therefore provide important constraints on the evolution of the Neo‐Tethys Ocean and India‐Asia collisional orogeny in southern Tibet.
Exploring the Influence of Land Use on the Urban Carbonyl Sulfide Budget: A Case Study of the Metropolitan Area of Barcelona
Authors: Estruch Carme , Belviso Sauveur , Badia Alba , Vidal Veronica , Curcoll Roger , Udina Mireia , Grossi Claudia , Morguí Josep‐Anton , Segura Ricard , Ventura Sergi , Sola Yolanda , Villalba Gara 
Published: December 2023

AbstractCarbonyl sulfide (OCS) is used to quantify the carbon capture potential of the biosphere because of its direct correlation with CO2 uptake during photosynthesis. However, to constrain the urban biosphere signal, it is necessary to evaluate potential anthropogenic sources. We conducted two sampling campaigns in the Metropolitan Area of Barcelona (AMB), Spain, during May (full COVID lockdown) and October 2020 to measure the spatial distribution and variability of OCS in four urban land uses as follows: built, urban forest, urban park, and peri‐urban agriculture. The OCS background levels determined at Tibidabo (442 m asl) were approximately 484 ± 20 ppt and 407 ± 8 ppt for May and October 2020, respectively, and agreed with other seasonal surveys conducted in Europe during that same period. Averaged emissions were in the range of +Δ12 ± 40 ppt for the city and were +Δ9.4 ± 40.9 ppt for urban +Δ22.1 ± 48 ppt for urban green +Δ20.7 ± 42.9 ppt for agricultural and −Δ4.8 ± 19.6 ppt for forest. The urban values ranged from neutral to above background, suggesting nearby anthropogenic and marine emissions such as +Δ150 ppt in Montjuic, which is downwind of Barcelona's harbor. During the crop‐growing season in May, the agricultural areas consistently showed values below the background (up to −Δ76 ppt in Gavà, uptake) at 7:00 UTC when the land breezes were dominant, while later in the morning, when the sea breeze are developed, the plant sink is masked by the transport of marine emissions. Urban forests located north of Tibidabo showed OCS values up to −Δ70 ppt, suggesting significant uptake by urban forests. We conclude that determining the urban biosphere signal using OCS as a tracer is more complex than expected because the marine and anthropogenic emissions from the port strongly impact the spatial‐temporal distribution of OCS.
The Ionospheric Exploration Based on TJU#01 Meteorological Microsatellite Mission: Initial Results
Authors: Wu M. J. , Guo P. , Li F. H. , Fu N. F. , Ma X. , Cheng Y. 
Published: December 2023

AbstractThe global navigation satellite system radio occultation technique is achieving increasing significance and extensive promotion in the remote sensing of near‐earth atmosphere, climate, and ionosphere in recent three decades. Nowadays, many communities become interested in developing commercial mode in occultation measurement by launching massive nano‐ or cube satellite constellations at low costs. The TJU#01 is the first meteorological satellite of Tianjin Yunyao Aerospace Technology Co., Ltd. which was successfully launched into space on 7 December 2021. The occultation antenna onboard the satellite is able to probe both the ionosphere and atmosphere at multi‐frequencies including GPS, GLONASS, and BEIDOU systems. The microsatellite applies the same occultation antenna to receive both the atmospheric and ionospheric occultations at 100 and 1 Hz respectively. 100 Hz narrow band power and wide band power data are downloaded to the ground to generate high‐rate signal‐to‐noise ratio (SNR) series and applied to ionospheric scintillation exploration. In this paper, the primary parameters of the satellite and occultation antenna are introduced, as well as the ionospheric data processing methodologies. The initial ionospheric products of TJU#01 are evaluated after one‐month in orbit. The TJU#01 results have a good agreement with the co‐located ground ionosonde data and COSMIC‐2 observations. The new satellite and its follow‐on missions have great capabilities and potentials in the ionospheric and space weather researches.
Rapid Permeability Upscaling of Digital Porous Media via Physics‐Informed Neural Networks
Authors: Elmorsy Mohamed , El‐Dakhakhni Wael , Zhao Benzhong 
Published: December 2023

AbstractSubsurface processes are important in solving many of the grand challenges facing our society today, including the sustainable extraction of hydrocarbons, the permanent geological sequestration of carbon dioxide, and the seasonal storage of renewable energy underground. Permeability characterization of underground rocks is the critical first step in understanding and engineering these processes. While recent advances in machine learning methods have enabled fast and efficient permeability prediction of digital rock samples, their practical use remains limited since they can only accommodate subsections of the digital rock samples, which is often not representative of properties at the core‐scale. Here, we derive a novel analytical solution that approximates the effective permeability of a three‐dimensional (3D) digital rock consisting of 2 × 2 × 2 anisotropic cells based on the physical analogy between Darcy’s law and Ohm’s law. We further develop physics‐informed neural network (PINN) models that incorporate the analytical solution and subsequently demonstrate that the PINN equipped with the physics‐informed module achieves excellent accuracy, even when used to upscale previously unseen samples over multiple levels of upscaling. Our work elevates the potential of machine learning models such as 3D convolutional neural network for rapid, end‐to‐end digital rock analysis at the core‐scale.
Neuroprotective therapies in the NICU in preterm infants: present and future (Neonatal Neurocritical Care Series)
Authors: Molloy Eleanor J. , El-Dib Mohamed , Soul Janet , Juul Sandra , Gunn Alistair J. , Bender Manon , Gonzalez Fernando , Bearer Cynthia , Wu Yvonne , Robertson Nicola J. , Cotton Mike , Branagan Aoife , Hurley Tim , Tan Sidhartha , Laptook Abbot , Austin Topun , Mohammad Khorshid , Rogers Elizabeth , Luyt Karen , Wintermark Pia , Bonifacio Sonia Lomeli ,   on behalf of the Newborn Brain Society Guidelines and Publications Committee, Bonifacio Sonia Lomeli , Wintermark Pia , Aly Hany , Chau Vann , Glass Hannah , Lemmon Monica , Wusthoff Courtney , deVeber Gabrielle , Pardo Andrea , Carrasco Melisa , Boardman James , Gano Dawn , Peeples Eric 
Published: December 2023

Abstract
The survival of preterm infants has steadily improved thanks to advances in perinatal and neonatal intensive clinical care. The focus is now on finding ways to improve morbidities, especially neurological outcomes. Although antenatal steroids and magnesium for preterm infants have become routine therapies, studies have mainly demonstrated short-term benefits for antenatal steroid therapy but limited evidence for impact on long-term neurodevelopmental outcomes. Further advances in neuroprotective and neurorestorative therapies, improved neuromonitoring modalities to optimize recruitment in trials, and improved biomarkers to assess the response to treatment are essential. Among the most promising agents, multipotential stem cells, immunomodulation, and anti-inflammatory therapies can improve neural outcomes in preclinical studies and are the subject of considerable ongoing research. In the meantime, bundles of care protecting and nurturing the brain in the neonatal intensive care unit and beyond should be widely implemented in an effort to limit injury and promote neuroplasticity.

Impact

With improved survival of preterm infants due to improved antenatal and neonatal care, our focus must now be to improve long-term neurological and neurodevelopmental outcomes.

This review details the multifactorial pathogenesis of preterm brain injury and neuroprotective strategies in use at present, including antenatal care, seizure management and non-pharmacological NICU care.

We discuss treatment strategies that are being evaluated as potential interventions to improve the neurodevelopmental outcomes of infants born prematurely.
ESRP1-driven alternative splicing of CLSTN1 inhibits the metastasis of gastric cancer
Authors: Li Chengguo , Yin Yuping , Tao Ruikang , Lin Yao , Wang Tao , Shen Qian , Li Runze , Tao Kaixiong , Liu Weizhen 
Published: December 2023

AbstractTumor metastasis severely limits the prognosis of gastric cancer patients. RNA-binding proteins (RBPs) are crucial in tumor metastasis, yet there is limited research into their involvement in gastric cancer. Here, we found that ESRP1, a RBP specific in epithelial cells, is important in regulating the metastasis of gastric cancer cells. ESRP1 is negatively correlated with distant metastasis and lymph node metastasis in gastric cancer patients. And we demonstrated that ESRP1 inhibit migration and invasion of gastric cancer in vitro and in vivo. Mechanistically, ESRP1 promotes exon 11 alternative splicing of CLSTN1 pre-mRNA. The post-splicing short CLSTN1 stabilizes the Ecadherin/β-catenin binding structure, and promotes β-catenin protein ubiquitination and degradation, thereby inhibiting the migration and invasion of gastric cancer cells. Our study highlights the role of ESRP1 in regulating metastasis of gastric cancer and extends its mechanism. These results provide a possibility for ESRP1 and CLSTN1 to become therapeutic targets for metastasis of gastric cancer.
Voltage sensors of a Na+ channel dissociate from the pore domain and form inter-channel dimers in the resting state
Authors: Sumino Ayumi , Sumikama Takashi , Shibata Mikihiro , Irie Katsumasa 
Published: December 2023

AbstractUnderstanding voltage-gated sodium (Nav) channels is significant since they generate action potential. Nav channels consist of a pore domain (PD) and a voltage sensor domain (VSD). All resolved Nav structures in different gating states have VSDs that tightly interact with PDs; however, it is unclear whether VSDs attach to PDs during gating under physiological conditions. Here, we reconstituted three different voltage-dependent NavAb, which is cloned from Arcobacter butzleri, into a lipid membrane and observed their structural dynamics by high-speed atomic force microscopy on a sub-second timescale in the steady state. Surprisingly, VSDs dissociated from PDs in the mutant in the resting state and further dimerized to form cross-links between channels. This dimerization would occur at a realistic channel density, offering a potential explanation for the facilitation of positive cooperativity of channel activity in the rising phase of the action potential.
Optimized design and in vivo application of optogenetically functionalized Drosophila dopamine receptors
Authors: Zhou Fangmin , Tichy Alexandra-Madelaine , Imambocus Bibi Nusreen , Sakharwade Shreyas , Rodriguez Jimenez Francisco J. , González Martínez Marco , Jahan Ishrat , Habib Margarita , Wilhelmy Nina , Burre Vanessa , Lömker Tatjana , Sauter Kathrin , Helfrich-Förster Charlotte , Pielage Jan , Grunwald Kadow Ilona C. , Janovjak Harald , Soba Peter 
Published: December 2023

AbstractNeuromodulatory signaling via G protein-coupled receptors (GPCRs) plays a pivotal role in regulating neural network function and animal behavior. The recent development of optogenetic tools to induce G protein-mediated signaling provides the promise of acute and cell type-specific manipulation of neuromodulatory signals. However, designing and deploying optogenetically functionalized GPCRs (optoXRs) with accurate specificity and activity to mimic endogenous signaling in vivo remains challenging. Here we optimize the design of optoXRs by considering evolutionary conserved GPCR-G protein interactions and demonstrate the feasibility of this approach using two Drosophila Dopamine receptors (optoDopRs). These optoDopRs exhibit high signaling specificity and light sensitivity in vitro. In vivo, we show receptor and cell type-specific effects of dopaminergic signaling in various behaviors, including the ability of optoDopRs to rescue the loss of the endogenous receptors. This work demonstrates that optoXRs can enable optical control of neuromodulatory receptor-specific signaling in functional and behavioral studies.
Neoadjuvant durvalumab plus radiation versus durvalumab alone in stages I–III non-small cell lung cancer: survival outcomes and molecular correlates of a randomized phase II trial
Authors: Altorki Nasser K. , Walsh Zachary H. , Melms Johannes C. , Port Jeffery L. , Lee Benjamin E. , Nasar Abu , Spinelli Cathy , Caprio Lindsay , Rogava Meri , Ho Patricia , Christos Paul J. , Saxena Ashish , Elemento Olivier , Bhinder Bhavneet , Ager Casey , Amin Amit Dipak , Sanfilippo Nicholas J. , Mittal Vivek , Borczuk Alain C. , Formenti Silvia C. , Izar Benjamin , McGraw Timothy E. 
Published: December 2023

AbstractWe previously reported the results of a randomized phase II trial (NCT02904954) in patients with early-stage non-small cell lung cancer (NSCLC) who were treated with either two preoperative cycles of the anti-PD-L1 antibody durvalumab alone or combined with immunomodulatory doses of stereotactic radiation (DRT). The trial met its primary endpoint of major pathological response, which was significantly higher following DRT with no new safety signals. Here, we report on the prespecified secondary endpoint of disease-free survival (DFS) regardless of treatment assignment and the prespecified exploratory analysis of DFS in each arm of the trial. DFS at 2 and 3 years across patients in both arms of the trial were 73% (95% CI: 62.1–84.5) and 65% (95% CI: 52.5–76.9) respectively. For the exploratory endpoint of DFS in each arm of the trial, three-year DFS was 63% (95% CI: 46.0–80.4) in the durvalumab monotherapy arm compared to 67% (95% CI: 49.6–83.4) in the dual therapy arm. In addition, we report post hoc exploratory analysis of progression-free survival as well as molecular correlates of response and recurrence through high-plex immunophenotyping of sequentially collected peripheral blood and gene expression profiles from resected tumors in both treatment arms. Together, our results contribute to the evolving landscape of neoadjuvant treatment regimens for NSCLC and identify easily measurable potential biomarkers of response and recurrence.
NDP52 mediates an antiviral response to hepatitis B virus infection through Rab9-dependent lysosomal degradation pathway
Authors: Cui Shuzhi , Xia Tian , Zhao Jianjin , Ren Xiaoyu , Wu Tingtao , Kameni Mireille , Guo Xiaoju , He Li , Guo Jingao , Duperray-Susini Aléria , Levillayer Florence , Collard Jean-Marc , Zhong Jin , Pan Lifeng , Tangy Frédéric , Vidalain Pierre-Olivier , Zhou Dongming , Jiu Yaming , Faure Mathias , Wei Yu 
Published: December 2023

AbstractAutophagy receptor NDP52 triggers bacterial autophagy against infection. However, the ability of NDP52 to protect against viral infection has not been established. We show that NDP52 binds to envelope proteins of hepatitis B virus (HBV) and triggers a degradation process that promotes HBV clearance. Inactivating NDP52 in hepatocytes results in decreased targeting of viral envelopes in the lysosome and increased levels of viral replication. NDP52 inhibits HBV at both viral entry and late replication stages. In contrast to NDP52-mediated bacterial autophagy, lysosomal degradation of HBV envelopes is independent of galectin 8 and ATG5. NDP52 forms complex with Rab9 and viral envelope proteins and links HBV to Rab9-dependent lysosomal degradation pathway. These findings reveal that NDP52 acts as a sensor for HBV infection, which mediates a unique antiviral response to eliminate the virus. This work also suggests direct roles for autophagy receptors in other lysosomal degradation pathways than canonical autophagy.
A type VII-secreted lipase toxin with reverse domain arrangement
Authors: Garrett Stephen R. , Mietrach Nicole , Deme Justin , Bitzer Alina , Yang Yaping , Ulhuq Fatima R. , Kretschmer Dorothee , Heilbronner Simon , Smith Terry K. , Lea Susan M. , Palmer Tracy 
Published: December 2023

AbstractThe type VII protein secretion system (T7SS) is found in many Gram-positive bacteria and in pathogenic mycobacteria. All T7SS substrate proteins described to date share a common helical domain architecture at the N-terminus that typically interacts with other helical partner proteins, forming a composite signal sequence for targeting to the T7SS. The C-terminal domains are functionally diverse and in Gram-positive bacteria such as Staphylococcus aureus often specify toxic anti-bacterial activity. Here we describe the first example of a class of T7 substrate, TslA, that has a reverse domain organisation. TslA is widely found across Bacillota including Staphylococcus, Enterococcus and Listeria. We show that the S. aureus TslA N-terminal domain is a phospholipase A with anti-staphylococcal activity that is neutralised by the immunity lipoprotein TilA. Two small helical partner proteins, TlaA1 and TlaA2 are essential for T7-dependent secretion of TslA and at least one of these interacts with the TslA C-terminal domain to form a helical stack. Cryo-EM analysis of purified TslA complexes indicate that they share structural similarity with canonical T7 substrates. Our findings suggest that the T7SS has the capacity to recognise a secretion signal present at either end of a substrate.
3D printing of self-healing personalized liver models for surgical training and preoperative planning
Authors: Lu Yahui , Chen Xing , Han Fang , Zhao Qian , Xie Tao , Wu Jingjun , Zhang Yuhua 
Published: December 2023

Abstract3D printing can produce intuitive, precise, and personalized anatomical models, providing invaluable support for precision medicine, particularly in areas like surgical training and preoperative planning. However, conventional 3D printed models are often significantly more rigid than human organs and cannot undergo repetitive resection, which severely restricts their clinical value. Here we report the stereolithographic 3D printing of personalized liver models based on physically crosslinked self-healing elastomers with liver-like softness. Benefiting from the short printing time, the highly individualized models can be fabricated immediately following enhanced CT examination. Leveraging the high-efficiency self-healing performance, these models support repetitive resection for optimal trace through a trial-and-error approach. At the preliminary explorative clinical trial (NCT06006338), a total of 5 participants are included for preoperative planning. The primary outcomes indicate that the negative surgery margins are achieved and the unforeseen injuries of vital vascular structures are avoided. The 3D printing of liver models can enhance the safety of hepatic surgery, demonstrating promising application value in clinical practice.
Effectiveness of caffeine and blue-enriched light on cognitive performance and electroencephalography correlates of alertness in a spaceflight robotics simulation
Authors: Flynn-Evans Erin E. , Rueger Melanie , Liu Andrew M. , Galvan-Garza Raquel C. , Natapoff Alan , Oman Charles M. , Lockley Steven W. 
Published: December 2023

AbstractHuman cognitive impairment associated with sleep loss, circadian misalignment and work overload is a major concern in any high stress occupation but has potentially catastrophic consequences during spaceflight human robotic interactions. Two safe, wake-promoting countermeasures, caffeine and blue-enriched white light have been studied on Earth and are available on the International Space Station. We therefore conducted a randomized, placebo-controlled, cross-over trial examining the impact of regularly timed low-dose caffeine (0.3 mg per kg per h) and moderate illuminance blue-enriched white light (~90 lux, ~88 melEDI lux, 6300 K) as countermeasures, separately and combined, in a multi-night simulation of sleep-wake shifts experienced during spaceflight among 16 participants (7 F, ages 26–55). We find that chronic administration of low-dose caffeine improves subjective and objective correlates of alertness and performance during an overnight work schedule involving chronic sleep loss and circadian misalignment, although we also find that caffeine disrupts subsequent sleep. We further find that 90 lux of blue-enriched light moderately reduces electroencephalogram (EEG) power in the theta and delta regions, which are associated with sleepiness. These findings support the use of low-dose caffeine and potentially blue-enriched white light to enhance alertness and performance among astronauts and shiftworking populations.
Aggregation-induced emission from optically active X-shaped molecules based on planar chiral [2.2]paracyclophane
Authors: Jikuhara Keishi , Inoue Ryo , Morisaki Yasuhiro 
Published: December 2023

AbstractAn optically active π-stacked molecule was synthesized incorporating planar chiral [2.2]paracyclophane and o-carborane units to impart circularly polarized luminescence and aggregation-induced emission properties to the molecule. The molecule exhibited a strong emission from the aggregated state in a mixed solvent system (H2O/THF) and the solid state in the PMMA matrix. In the aggregated state, weak circularly polarized luminescence was observed owing to the random intermolecular orientation. On the other hand, the circularly polarized luminescence was clearly observed in the PMMA film containing 1 wt% molecule. Theoretical studies using time-dependent density functional theory reproduced the molecule’s circular dichroism and circularly polarized luminescence properties.