bluuebunny/crossref_metadata_2025_split huggingface dataset:
Ethical leadership of head nurses perceived by nurses and its relationship with nurses’ organizational justice
Authors: She Jiachen , Cai Zongao , Li Yanan , Zhang Ruixing , Mei Yongxia , Li Hongfeng 
Published: February 2024

Abstract
Background: Ethical leadership is an altruistic-centered, ethical norm-driven leadership style that can help foster positive work attitudes among nurses. However, the relationship between ethical leadership by nurse leaders and nurses' sense of organizational justice has not been adequately studied.
Objective: To investigate the level of ethical leadership among head nurses and its relationship with organizational justice among nurses.
Method：This cross-sectional study was conducted with a convenience sample of 501 clinical nurses from four tertiary-level hospitals in Zhengzhou, Henan Province of China in May 2023. The Ethical Leadership at Work Questionnaire and the Organizational Justice Scale were used as data collection instruments. Multiple stratified linear regression was used to analyze the relationships.
Results：The mean score of ethical leadership of head nurses was 4.13±0.46, which is at a high level. Marital status, department, and monthly income were the influencing factors of nurses’ perceived ethical leadership. Head nurses’ ethical leadership was positively correlated with nurses’ organizational justice (r = 0.513, P < 0.01). Stratified linear regression analysis showed that the people orientation, power sharing and sustainability dimensions explained 23.0% of the variance in nurses’ organizational justice (P< 0.05).
Conclusions: The subscales of people orientation, power sharing and sustainability significantly influence nurses’ organizational justice. Therefore, nurse managers need to pay more attention to nurses’ personal development and needs, give them more opportunities to participate in decision-making, and strengthen their organizational justice.
Real-World experience of water vapour therapy (Rezum) in patients with benign prostatic enlargement: a retrospective single-center study
Authors: Wolters Mathias , Krastel Martin , Winkler Thorben , Idais Hamza , Mazdak Mehrdad , Tezval Hossein , Kuczyk Markus , von Klot Christoph-Alexander 
Published: February 2024

Abstract

Background Water vapor thermal therapy (Rezum) is a minimally invasive treatment for benign prostatic enlargement (BPE). Studies reporting urodynamic results regarding the procedure are rare. Our study aimed to assess the effectiveness of Rezum on urinary outcome parameters in a consecutive series of patients and compare urodynamic data before and after treatment.Methods We retrospectively evaluated all the patients treated with Rezum between 07/2017 and 12/2023 at our institution. Patients who had more than one Rezum intervention, those who were unable to void (i.e., catheter-dependent patients), and those with insufficient data were excluded from the data analysis. Descriptive outcomes, such as symptom scores (IPSS, IPSS-QoL), peak flow in uroflowmetry (Qmax), post-micturition residual urine volume (PVR), and prostate volume (PVol), were analyzed. If available, preoperative and postoperative urodynamic results were evaluated.Results In total, 250 Rezum procedures were performed during the observational period. After applying the exclusion criteria, the data from 193 patients were included in the analysis. Patients achieved significant symptom relief as measured using the IPSS (46% reduction) and IPSS-QoL scores (41% reduction). Qmax improved by 4.8 ml/s, as the mean PVR significantly decreased by 50%. PVol and PSA values decreased by 30% and 27.5%, respectively. In 19/193 patients with a urodynamic evaluation, pre- and postoperative data analysis showed a significant reduction in the bladder outlet obstruction index (BOOI) by approximately 70%.Conclusions Rezum is effective and can improve urinary symptoms. In appropriate patients, Rezum can significantly reduce the bladder outlet obstruction (BOO).
The recycling substitute of pilosula velutipes in the growth medium: from the perspective of microbiomics
Authors: wang le 
Published: February 2024

Abstract
Using waste cotton as substrate for straw mushroom production has great nutritional support value and commercial value. The production of Volvariella volvacea depends on the physicochemical and microbial properties of the substrate. Due to the strong influence of microorganisms and the complexity of substrate culture, Volvariella volvacea production was finally induced under controlled environmental conditions. The interaction of microorganisms in the process of substrate fermentation has greatly affected the production and colonization of Volvariella volvacea. In this study, the characteristics and production performance of bacterial microbiota in Volvariella volvacea substrate (fermentation period) were compared, and the microbial community in Volvariella volvacea substrate was identified. The growth of Volvariella volvacea changed the microbial composition and structure of substrate. 16S rRNA was used to study the microbial diversity of Volvariella volvacea culture material at different stages and its effect on substrate.The results showed that: in the whole fermentation cycle, the total number of bacterial species in the substrate was negatively correlated with time, and the abundance of Proteus in the substrate was high (accounting for 40%), which decreased first and then increased with the fermentation time. In all samples, at the species level, the relative abundance of amino acid metabolism and sugar metabolism was high, which reflected that the substrate played a great role in nourishing Volvariella volvacea.The technology used in this study provides the overall and detailed characteristics of microbial composition changes in Volvariella volvacea substrate. Analyze the influence of substrate microorganisms on Volvariella volvacea culture, determine the most suitable substrate environment, improve resource utilization, understand the optimal fermentation conditions corresponding to substrate formula, effectively use different substrates in different regions as substrates for Volvariella volvacea culture, and reduce the transportation cost of raw materials. Improve the profits of edible fungi industry. The knowledge generated will help to improve matrix formulation (selection of base materials) and accelerate matrix production, for example, through biotechnology interventions in the form of customized biostimulants and the design of environmentally sustainable bio based materials.
Anastomotic leak occurs independently from microbiota shifts associated with surgical bowel preparation
Authors: Boatman Sonja , Khan Mohammad Haneef , Ganesan Nirupa , Nalluri-Butz Harika , Kohn Julia , Troester Alexander , Madoff Robert , Gaertner Wolfgang B. , Jahansouz Cyrus , Staley Christopher 
Published: February 2024

Abstract
Background
Following bowel surgery, microbially driven complications, including anastomotic leak (AL) and surgical site infections (SSI), remain major sources of morbidity and mortality. For more than 50 years, bowel preparation has been administered with the assumption that gut decontamination serves to reduce post-surgical complications. Here, we test this hypothesis in a murine model of colon surgery fed either regular chow or a high-fat, high-sugar Western diet. Mice then received one of four interventions the day before colon surgery: water (control), mechanical bowel preparation (MBP), oral antibiotics (OA), or both MBP and OA. Mice were subsequently assessed for AL and wound healing.
Results
Despite predicted changes in the microbiome, no differences in the rates of AL or wound breakdown were observed. Changes in fecal short-chain fatty acids were noted but did not reflect specific effects of treatment or AL; however, fecal IgA was greater in mice fed WD and among those who had AL (P = 0.007). RNAseq analysis of transcript abundances similarly did not reveal significant mechanistic pathways associated with AL.
Conclusions
While we did identify bacterial genera that may be causally associated with AL and could be used to develop a predictive index, future work is required to elucidate specific mechanistic pathways driving AL.
Prognostic analysis of patients with liver metastasis from gastric cancer and establishment and verification of a survival nomogram
Authors: Chen Guizeng , Li Zikang , Fang Qian , Cai Guojing , Zeng Haifeng , Xu Xiang , He Yulong , Cai Shirong , Wu Hui 
Published: February 2024

Abstract

Gastric cancer (GC) is one of the most common malignant tumors in the digestive tract. Liver metastasis is the most common mode of hematogenous metastasis. Patients with GC with liver metastasis (GCLM) progress rapidly and have a poor prognosis. Therefore, there is an urgent need for a method that can combine the patient's basic condition and tumor characteristics to predict the patient's prognosis. This study used the SEER database to explore the relevant risk factors for the prognosis of GCLM, and established a nomogram with good survival prediction ability, in order to facilitate personalized prognosis evaluation and follow-up strategy formulation for patients in clinical practice. We found that age, pathological grade, surgery, and chemotherapy are independent risk factors affecting the prognosis of GCLM. We established a nomogram for the prognosis of GCLM based on the four independent risk factors mentioned above, and conducted internal and external validation using the SEER database and the First Affiliated Hospital of Sun Yat-sen University database. The results showed that the nomogram has good predictive ability and can be used to assist clinical doctors in evaluating patient prognosis and formulating personalized follow-up strategies, while making corresponding personalized treatments as early as possible.
Kindlin-2 Regulates the Oncogenic Activities of Integrins and TGF-β In Triple Negative Breast Cancer Progression and Metastasis
Authors: Yousafzai Neelum Aziz , Khalki Lamyae El , Wang Wei , Szpendyk Justin , Sossey-Alaoui Khalid 
Published: February 2024

Abstract

BackgroundKindlin-2, an adaptor protein, is dysregulated in various human cancers, including triple negative breast cancer (TNBC), where it drives tumor progression and metastasis by influencing several cancer hallmarks. One well-established role of Kindlin-2 involves the regulation of integrin signaling, achieved by directly binding to the cytoplasmic tail of the integrin β subunit. In this study, we present novel insights into Kindlin-2's involvement in stabilizing the β1-Integrin:TGF-β type 1 receptor (TβRI) complexes, acting as a physical bridge that links β1-Integrin to TβRI. The loss of Kindlin-2 results in the degradation of this protein complex, leading to the inhibition of downstream oncogenic pathways.MethodsOur methodology encompassed a diverse range of in vitro assays, including CRISPR/Cas9 gene editing, cell migration, 3D tumorsphere formation and invasion, solid binding, co-immunoprecipitation, cell adhesion and spreading assays, as well as western blot and flow cytometry analyses, utilizing MDA-MB-231 and 4T1 TNBC cell lines. Additionally, preclinical in vivo mouse models of TNBC tumor progression and metastasis were employed to substantiate our findings.ResultsThe investigation revealed that the direct interaction between Kindlin-2 and β1-Integrin is mediated through the C-terminal F3 domain of Kindlin-2, while the interaction between Kindlin-2 and TβRI is facilitated through the F2 domain of Kindlin-2. Disruption of this bridge, achieved via CRISPR/Cas9-mediated knockout of Kindlin-2, led to the degradation of β1-Integrin and TβRI, resulting in the inhibition of oncogenic pathways downstream of both proteins, subsequently hindering tumor growth and metastasis. Treatment of Kindlin-2-deficient cells with the proteasome inhibitor MG-132 restored the expression of both β1-Integrin and TβRI. Furthermore, the rescue of Kindlin-2 expression reinstated their oncogenic activities both in vitro and in vivo.ConclusionsThis study identifies a novel function of Kindlin-2 in stabilizing the β1-Integrin:TβR1 complexes and regulating their downstream oncogenic signaling. The translational implications of these findings are substantial, potentially unveiling new therapeutically targeted pathways crucial for the treatment of TNBC tumors.
Absence of Causal Relationship between Levels of Unsaturated Fatty Acids and Attention-Deficit/Hyperactivity Disorder: Evidence from Mendelian Randomization Study
Authors: Wang Zuxing , Chen Lili , Min Wenjiao , Xiao Jun , Zou Zhili , He Ying 
Published: February 2024

Abstract
Objective Previous research suggests a potential link between unsaturated fatty acids (UFAs) and attention-deficit/hyperactivity disorder (ADHD), but the causal relationship remains uncertain. This study aims to investigate the causal association between ADHD and UFAs using Mendelian randomization (MR) analysis.
Methods Summary data from genome-wide association studies were used to estimate UFAs levels, including Monounsaturated Fatty Acids (MUFAs), Polyunsaturated Fatty Acids (PUFAs), Omega-3 PUFAs, Omega-6 PUFAs, Linoleic Acid (LA), and Docosahexaenoic Acid (DHA), in a sample of 114,999 participants from the UK Biobank. Data from the Psychiatric Genomics Consortium, consisting of 38,691 individuals with ADHD and 186,843 controls, were used to examine the relationship between genetically predicted UFAs levels and ADHD. Various MR methods, including Inverse-variance weighted, MR Pleiotropy RESidual Sum and Outlier, MR-Egger, weighted median, and weighted mode, were employed to assess heterogeneity and pleiotropy.
Results The Inverse-variance weighted method revealed only nominal evidence suggesting a potential causal relationship between genetically predicted PUFAs (OR = 0.92, 95% CI = 0.85-0.99, p = 0.031), Omega-6 PUFAs (OR = 0.90, 95% CI = 0.83-0.98, p = 0.020), and LA levels (OR = 0.90, 95% CI = 0.82-0.98, p = 0.021) with ADHD risk. However, after false discovery rate (FDR) correction, the p-values for PUFAs, Omega-6 PUFAs, and LA levels were 0.063, 0.062, and 0.062 respectively, which indicates that no effect of UFAs level on ADHD risk was found.
Conclusion Our findings do not support a causal relationship between UFAs levels and ADHD, aligning with previous research results, suggesting that the use of UFAs supplements does not confer beneficial effects on ADHD symptoms.
Inverse Correlation Between Age of Onset and Myocardial Amyloid Deposition Quantified by 99mTc-PYP Scintigraphy in Patients with Wild-type Transthyretin Amyloid Cardiomyopathy
Authors: Kanaya Hiroshi , Shiraishi Shinya , Ogasawara Kouji , Iwashita Koya , Sakamoto Fumi , Takashio Seiji , Mikami Yoshiki , Tsujita Kenichi , Hirai Toshinori 
Published: February 2024

Abstract

Objective
Wild-type transthyretin amyloidosis cardiomyopathy (ATTRwt-CM) is increasingly recognized as a contributing factor to cardiac insufficiency in the elderly population. We aimed to identify the factors affecting age of onset of ATTRwt-CM, encompassing the assessment of amyloid deposition in myocardial tissue through the use of 99mTc-pyrophosphate (PYP) and clinical parameters.
Methods
A retrospective investigation involving a consecutive cohort of 107 cases, each having been diagnosed with ATTRwt-CM confirmed through histopathological and genetic analysis. All patients underwent PYP scintigraphy and the heart to contralateral (H/CL) ratio was calculated to measure amyloid deposition in the myocardium. Univariate and multivariate analysis were performed to identify independent predictors of the age of onset of ATTRwt-CM, considering the H/CL ratio and various clinical risk factors for heart failure.
Results
Gender (p = 0.029), Creatinine (Cr) (r = 0.315, p < 0.001), hemoglobin (Hb) (r = -0.437, p < 0.001), albumin (Alb) (r = -0.318, p < 0.001), brain natriuretic peptide (BNP) (r = 0.214, p = 0.028), low density lipoprotein-cholesterol (LDL-C) (r = -0.267, p = 0.006), and H/CL ratio (r = -0.439, p < 0.001) were all significantly associated with the onset age. In multiple regression analysis, the independent predictive factors for the onset age of ATTRwt-CM were identified as the H/CL ratio (p < 0.001), Hb (p = 0.003), and Cr (p = 0.018).
Conclusions
The H/CL ratio, Hb, and Cr independently affect age of onset in patients with ATTRwt-CM. The H/CL ratio is inversely correlated with age of onset, and may be the sole factor in the development of heart failure in early-onset patients, while it may have a synergistic effect on heart failure with anemia and renal dysfunction in late-onset patients.
Is There a Causal Connection? Mendelian Randomization Analysis of Muscular Dystrophies and Non-Alcoholic Fatty Liver Diseases
Authors: Lai Guanzhi , Bai Shangzhe , Sun Chengjun , Xia Wuzheng , Wei Xiangling , Han Ming , Shi Shaojun , Wu Linwei 
Published: February 2024

Abstract
Background
Muscular dystrophies (MD) are a group of genetically inherited disorders characterized by progressive muscle degeneration. Prior observational studies have indicated potential, yet inconclusive, links between MD and liver conditions such as non-alcoholic fatty liver disease (NAFLD) and nonalcoholic steatohepatitis (NASH). Despite these associations, a definitive causal relationship between MD and NAFLD has not been firmly established.
Objective
Our objective was to assess the potential causal relationships between of MD and liver conditions such as NAFLD and/or NASH, using the latest data available.
Methods
We employed a two-sample Mendelian Randomization (MR) approach, drawing on genome-wide association study (GWAS) summary statistics for MD and NAFLD/NASH. Furthermore, we performed sensitivity analyses to ensure the reliability and robustness of our findings.
Results
Our findings did not reveal any significant evidence supporting a causal link between MD and NAFLD (NSNP = 8, odds ratio [OR]: 0.986, 95% CI: 0. 931-1.043, P = 0.62) or NASH (NSNP = 8, odds ratio [OR]: 0.859, 95% CI: 0.692–1.066, P = 0.17). The statistical analysis indicated that the causality between MD and NAFLD/NASH was not significant (P > 0.05). Furthermore, our sensitivity analysis did not identify any significant heterogeneity or instances of horizontal pleiotropy.
Conclusions
The study concludes that there is no substantial evidence to suggest a causal relationship between MD and NAFLD/NASH. This finding could lead to a reevaluation of the necessity for extensive and potentially costly liver investigations in MD patients. It also suggests that other confounding factors might be at play in the previously observed associations, highlighting the need for further research in this area.
Modified Tractive Force Approach for Sediment Transport Under Bank Seepage
Authors: Sharma Himanshu 
Published: February 2024

Abstract
Present study deals with the inclusion of effect of seepage with the tractive force approach for a sediment particle resting on the porous bank. A formula was derived based upon the tractive force approach to estimate the critical shear stress acting on the sediment particle under the seepage condition. Study showed that hydraulic gradient affects the critical shear stress and later was observed to increase with increase in the hydraulic gradient. Inclusion seepage also affected the design of channels as cross sectional parameters were observed to be affected by the seepage.
Increasing Trends of Pharmaceutical Payments to Breast Cancer Specialists in Japan: A Retrospective Study from 2016 to 2019
Authors: Kaneda Yudai , Yamashita Erika , Saito Hiroaki , Gonda Kenji , Wada Masahiro , Tanimoto Tetsuya , Ozaki Akihiko 
Published: February 2024

Abstract
Introduction:
The interplay between pharmaceutical companies and healthcare professionals is a critical facet of modern medicine, with financial relationships often influencing clinical practice. This study examines its impact on clinical practice in Japan, particularly in breast cancer treatment. It aims to uncover the prevalence, magnitude, and trends of payments made to breast cancer specialists by the pharmaceutical industry, thereby increasing transparency in these financial interactions.
Methods:
A retrospective analysis included breast cancer specialists certified by the Japanese Breast Cancer Society as of May 2023. Payment data from 2016 to 2019 were collected from 93 pharmaceutical companies in the Japan Pharmaceutical Manufacturers Association, focusing on payments for lecturing, writing, and consulting.
Results:
The analysis revealed an upward trend in pharmaceutical payments, with a total of USD 13,329,910.57 between 2016 and 2019, reflecting an average annual growth rate of 10.1%. The majority of these payments (81.4%) were for speaking engagements. The top 10 pharmaceutical companies made 89.5% of the total payments, with a spike in payments following the introduction of new drugs. Payment distribution was highly concentrated, as evidenced by a high Gini index, indicating a skew towards a few specialists.
Conclusion:
From 2016 to 2019, there was a notable rise in pharmaceutical payments to Japanese breast cancer specialists, paralleling the introduction of new drugs. The study highlights the need for continuous monitoring of these financial relationships to ensure unbiased clinical decisions and uphold healthcare integrity. Transparent and fair financial practices are essential for maintaining trust in healthcare and prioritizing patient care.
skyline query under multidimensional incomplete data based on classification tree
Authors: Yuan Dengke , Zhang Liping , Li Song , Sun Guanglu 
Published: February 2024

Abstract

A method for skyline query of multidimensional incomplete data based on a classification tree has been proposed to address the problem of a large amount of useless data in existing skyline queries with multi-dimensional incomplete data, which leads to low query efficiency and algorithm performance. This method consists of two main parts. The first part is the proposed incomplete data weighted classification tree algorithm. In the first part, an incomplete data weighted classification tree is proposed, and the incomplete data set is classified using this tree. The data classified in the first part serves as the basis for the second step of the query. The second part proposes a skyline query algorithm for multi-dimensional incomplete data. The concept of optimal virtual points has been recently introduced, effectively reducing the number of comparisons of a large amount of data, thereby improving the query efficiency for incomplete data. Theoretical research and experimental analysis have shown that the proposed method can perform skyline queries for multi-dimensional incomplete data well, with high query efficiency and accuracy of the algorithm.