bluuebunny/crossref_metadata_2025_split huggingface dataset:
Cardiac Reverse Remodeling and Changes in Heart Failure Indices After Transcatheter Tricuspid Valve Replacement in Adults With Congenital Heart Disease
Authors: Salama Abdalla A. , Abozied Omar A. , Anderson Jason H. , Miranda William R. , Connolly Heidi M. , Jain Charles , Cabalka Allison , Egbe Alexander C. 
Published: November 2023

BACKGROUND:
There are limited data about changes in cardiac function (cardiac reverse remodeling) and heart failure indices after transcatheter tricuspid valve-in-valve replacement (TT-VIVR). The purpose of this study was to evaluate cardiac reverse remodeling and temporal changes in heart failure indices after TT-VIVR in adults with congenital heart disease.

METHODS:
Retrospective cohort study of adults with congenital heart disease that underwent TT-VIVR and had >6 months of follow-up (January 1, 2011, to April 30, 2023). Echocardiographic indices of cardiac remodeling and heart failure indices (New York Heart Association class, NT-proBNP (N-terminal pro-brain natriuretic peptide), glomerular filtration rate, and model for end-stage liver disease excluding international normalized ratio score) were assessed preintervention and at 1-, 3-, and 5-year postintervention.

RESULTS:

Of 39 patients (age 39 [32–46] years), 14 (36%) and 25 (64%) received Melody valve and Sapien valve prosthesis, respectively. At 1-year post-TT-VIVR, there was a temporal improvement in right atrial reservoir strain (17±8% versus 22±8%,
P
<0.001), right atrial volume (81 [59–108] versus 63 [48–82] mL/m
2
,
P
<0.001), right atrial pressure (12±4% versus 6±4%,
P
<0.001), and right ventricular global longitudinal strain (−15±7% versus −20±7%,
P
<0.001). Similarly, there was a temporal improvement in NT-proBNP, glomerular filtration rate, model for end-stage liver disease excluding international normalized ratio score, and New York Heart Association class. The temporal improvements in heart failure indices and valve function were maintained at 3- and 5-year post-TT-VIVR.

CONCLUSIONS:
Considering the significant mortality risk associated with reoperations for tricuspid valve replacement, these data suggest favorable outcomes after TT-VIVR, and support TT-VIVR as a viable alternative to surgical tricuspid valve replacement, especially in high-risk patients.
The Interaction of Context Constraints and Predictive Validity during Sentence Reading
Authors: Terporten René , Huizeling Eleanor , Heidlmayr Karin , Hagoort Peter , Kösem Anne 
Published: November 2023

Abstract
Words are not processed in isolation; instead, they are commonly embedded in phrases and sentences. The sentential context influences the perception and processing of a word. However, how this is achieved by brain processes and whether predictive mechanisms underlie this process remain a debated topic. Here, we employed an experimental paradigm in which we orthogonalized sentence context constraints and predictive validity, which was defined as the ratio of congruent to incongruent sentence endings within the experiment. While recording electroencephalography, participants read sentences with three levels of sentential context constraints (high, medium, and low). Participants were also separated into two groups that differed in their ratio of valid congruent to incongruent target words that could be predicted from the sentential context. For both groups, we investigated modulations of alpha power before, and N400 amplitude modulations after target word onset. The results reveal that the N400 amplitude gradually decreased with higher context constraints and cloze probability. In contrast, alpha power was not significantly affected by context constraint. Neither the N400 nor alpha power were significantly affected by changes in predictive validity.
Mental Simulations and Action Language Are Impaired in Individuals with Aphantasia
Authors: Dupont William , Papaxanthis Charalambos , Lebon Florent , Madden-Lombardi Carol 
Published: November 2023

Abstract
Action reading is thought to engage motor simulations, such as those involved during the generation of mental motor images. These simulations would yield modulations in activity of motor-related cortical regions and contribute to action language comprehension. To test these ideas, we measured corticospinal excitability during action reading, and reading comprehension ability, in individuals with normal and impaired imagery (i.e., phantasia and aphantasia, respectively). Thirty-four participants (17 phantasic and 17 aphantasic) were asked to read manual action sentences. By means of TMS, we triggered motor-evoked potentials in the target right index finger. Motor-evoked potential amplitude, a marker of corticospinal excitability, increased during action reading relative to rest for phantasic individuals, but not for aphantasic individuals. This result provides neurophysiological evidence that individuals living with aphantasia present a real neurophysiological deficit in motor system engagement during action reading. Furthermore, deep-level reading comprehension ability was impaired in individuals with aphantasia, who had difficulty selecting words that best fit the context of sentences. Altogether, these findings support the idea that motor simulations, along with the activation within the motor system, contribute to action language comprehension.
Morphological and molecular characterisation of Longidorus patuxentensis n. sp. (Nematoda: Longidoridae) from Maryland and California, USA
Authors: Kantor Mihail R. , Subbotin Sergei A. , Im Bill , Handoo Zafar A. 
Published: November 2023

Summary
A new needle nematode species, Longidorus patuxentensis n. sp., was collected along the banks of the Western Branch Patuxent River from Upper Marlboro, MD, USA, and described herein. Female body length of the new species ranges from 3.8 to 5.2 mm, with a set off lip region by depression, 77-92 μm long odontostyle, 40-53 μm long odontophore, vulva located at 46.3-50.1% and tail conoid with bluntly rounded tip. The new species has four juvenile developmental stages and no males. It looks morphologically similar to L. breviannulatus, L. elongatus, L. martini, L. americanus, L. grandis, L. sabalanicus and L. sturhani by having a ventrally curved to spiral body, generally similar lip region and conoid tail with a rounded terminus, but differs from these species by the odontostyle, odontophore, total stylet length and a few other characters. Phylogenetic analysis of the D2-D3 expansion segments of 28S rRNA gene sequences placed L. patuxentensis n. sp. in a clade with L. litchi, L. fangi, L. jonesi, L. diadecturus and Longidorus sp. The D2-D3 sequence of L. patuxentensis n. sp. was identical to that of Longidorus sp.5 collected from Juglans sp. growing in Butte County, California, USA. The D2-D3 of 28S and ITS1 rRNA and COI gene sequences indicated that the Maryland and California populations belong to the same species, described herein as L. patuxentensis n. sp.
Influences of Cloud Vertical Overlapping on the Calculated Cloud Albedo and Their Validation with Satellite Observations
Authors: Zhang Hua , Wang Haibo , Liu Yangang , Jing Xianwen , Liu Yi 
Published: November 2023

Abstract
Cloud albedo is expected to influence cloud radiative forcing in addition to cloud fraction, and inadequate description of the cloud overlapping effects on the cloud fraction may influence the simulated cloud fraction, and thus the relative cloud radiative forcing (RCRF) and cloud albedo. In this study, we first present a new formula by extending that presented previously to consider multilayer clouds directly in the relationship between cloud albedo, cloud fraction, and RCRF, and then quantitatively evaluate the effects of different cloud vertical overlapping structures, represented by the decorrelation length scales (Lcf), on the simulated cloud albedos. We use the BCC_AGCM2.0_CUACE/Aero model with simultaneous validation by observations from the Clouds and the Earth’s Radiation Energy System (CERES) satellite. When Lcf < 4 km (i.e., the cloud overlap is closer to the random overlap), the simulated cloud albedos are generally in good agreement with the satellite-based albedos for December–February and June–August; when Lcf ≥ 4 km (i.e., the cloud vertical overlap is closer to the maximum overlap), the difference between simulated and observed cloud albedos became larger, due mainly to significant differences in cloud fractions and RCRF. Further quantitative analysis shows that the relative Euclidean distance, which represents the degree of overall model–observation disagreement, increases with the Lcf for all three variables (cloud albedo, cloud fraction, and RCRF), indicating the importance of cloud vertical overlapping in determining the accuracy of the calculated cloud albedo for multilayer clouds.

Significance Statement
The purpose of this study is presenting a new formula to consider multilayer clouds directly in the relationship between cloud albedo, cloud fraction, and relative cloud radiative forcing (RCRF). This is important because the effects of different cloud vertical overlapping structures, represented by the decorrelation length scales (Lcf), can affect the simulated cloud albedos. Our results provide a guide on the importance of cloud vertical overlapping in determining the accuracy of the calculated cloud albedo for multilayer clouds.
Wave Modulation in a Strong Tidal Current and Its Impact on Extreme Waves
Authors: Halsne Trygve , Benetazzo Alvise , Barbariol Francesco , Christensen Kai Håkon , Carrasco Ana , Breivik Øyvind 
Published: November 2023

Abstract
Accurate estimates of extreme waves are central for maritime activities, and stochastic wave models are the best option available for practical applications. However, the way currents influence the statistics of space–time extremes in spectral wave models has not been properly assessed. Here we demonstrate impacts of the wave modulation caused by one of the world’s strongest open ocean tidal currents, which reaches speeds of at least 3 m s−1. For a bimodal swell and wind sea state, we find that most intense interactions occur when the wind sea opposes the tidal current, with an increase in significant wave height and spectral steepness up to 45% and 167%, respectively. The steepness modulation strengthens the second-order Stokes contribution for the normalized extreme crests, which increases between 5% and 14% during opposing wind sea and current. The normalized extreme wave heights have a strong dependence on the narrow-bandedness parameter, which is sensitive to the variance distribution in the bimodal spectrum, and we find an increase up to 12% with currents opposing the wind sea. In another case of swell opposing a tidal jet, we find the spectral steepness to exceed the increase predicted by a simplified modulation model. We find support in single-point observations that using tidal currents as forcing in wave models improves the representation of the expected maximum waves, but that action must be taken to close the gap of measurements in strong currents.

Significance Statement
The purpose of this study is to investigate how a very strong tidal current affects the surface wave field, and how it changes the stochastic extreme waves formulated for a space–time domain. Our results suggest that the expected maximum waves become more realistic when tidal currents are added as forcing in wave models. Here, the expected extremes exceed traditional model estimates, i.e., without current forcing, by more than 10%. These differences have implications for maritime operations, both in terms of planning of marine structures and for navigational purposes. However, there is a significant lack of observations in environments with such strong currents, which are needed to further verify our results.
Information Access Effort: The Role of Head Movements for Information Presented at Increasing Eccentricity on Flat Panel and Head-Mounted Displays
Authors: Warden Amelia C. , Wickens Christopher D. , Clegg Benjamin A. , Rehberg Daniel , Ortega Francisco R. 
Published: November 2023

Objective This experiment examined performance costs when processing two sources of information positioned at increasing distances using a flat panel display and an augmented reality head-mounted display (AR-HMD). Background The AR-HMD enables positioning virtual information at various distances in space. However, the proximity compatibility principle suggests that closer separation when two sources of information require mental integration assists performance, whereas increased separation between two sources hurts integration performance more than when a single source requires focused attention. Previous studies have provided inconsistent findings regarding costs associated with increased separation. Few of these experiments have examined separation for both focused and integration tasks, compared vertical and lateral separation, or measured head movements. Method Three experiments collectively examined these issues using a flat panel display and a virtual display presented with an HMD, where the separation of information varied laterally or vertically during a focused attention (digit reading) task and an information integration (mental subtraction) task. Results There was no performance cost for either display when information was increasingly separated. However, head movements mitigated performance costs by preserving accuracy at larger separations without increasing response time. Conclusion Head movements appear to mitigate performance costs associated with presenting information increasingly far apart on flat panel displays and HMDs. Both eye scanning and head movements appear to be less effortful than expected. Application These findings have important implications for design guidelines regarding the placement of information presented on flat panel displays and, more specifically, HMDs, which can present information 360° around the user.
Identification and development of TP53 mutation-associated Long non-coding RNAs signature for optimized prognosis assessment and treatment selection in hepatocellular carcinoma
Authors: Chu Chenghao , Liu Daoli , Wang Duofa , Hu Shuangjiu , Zhang Yongwei 
Published: November 2023

Background The TP53 gene is estimated to be mutated in over 50% of tumors, with the majority of tumors exhibiting abnormal TP53 signaling pathways. However, the exploration of TP53 mutation-related LncRNAs in Hepatocellular carcinoma (HCC) remains incomplete. This study aims to identify such LncRNAs and enhance the prognostic accuracy for Hepatoma patients. Material and Methods Differential gene expression was identified using the “limma” package in R. Prognosis-related LncRNAs were identified via univariate Cox regression analysis, while a prognostic model was crafted using multivariate Cox regression analysis. Survival analysis was conducted using Kaplan–Meier curves. The precision of the prognostic model was assessed through ROC analysis. Subsequently, the Tumor Immune Dysfunction and Exclusion (TIDE) algorithm were executed on the TCGA dataset via the TIDE database. Fractions of 24 types of immune cell infiltration were obtained from NCI Cancer Research Data Commons using deconvolution techniques. The protein expression levels encoded by specific genes were obtained through the TPCA database. Results In this research, we have identified 85 LncRNAs associated with TP53 mutations and developed a corresponding signature referred to as TP53MLncSig. Kaplan–Meier analysis revealed a lower 3-year survival rate in high-risk patients (46.9%) compared to low-risk patients (74.2%). The accuracy of the prognostic TP53MLncSig was further evaluated by calculating the area under the ROC curve. The analysis yielded a 5-year ROC score of 0.793, confirming its effectiveness. Furthermore, a higher score for TP53MLncSig was found to be associated with an increased response rate to immune checkpoint blocker (ICB) therapy ( p = .005). Patients possessing high-risk classification exhibited lower levels of P53 protein expression and higher levels of genomic instability. Conclusion The present study aimed to identify and validate LncRNAs associated with TP53 mutations. We constructed a prognostic model that can predict chemosensitivity and response to ICB therapy in HCC patients. This novel approach sheds light on the role of LncRNAs in TP53 mutation and provides valuable resources for analyzing patient prognosis and treatment selection.
The Pathway Building Technique in Implementation Research Using Mixed Methods Design
Authors: Younas Ahtisham , Porr Caroline , Maddigan Joy , Moore Julia E , Navarro Pablo , Whitehead Dean 
Published: November 2023

Background Data integration refers to combining quantitative and qualitative data in mixed methods. It can be achieved through several integration procedures. The building integration procedure can be used for developing quantitative instruments by integrating data from the qualitative phase. There are limited examples of data integration using the building procedure in mixed methods and implementation science. Purpose The purpose of this article is to illustrate how the pathway building technique can be used to integrate data in mixed methods research through concurrent use of implementation science models and frameworks. Methods This two pathway building technique was developed based on a mixed methods implementation project of developing implementation strategies to promote compassionate nursing care of complex patients. Results The first pathway is the integration of qualitative data from the first phase of mixed methods study with implementation models and frameworks to create a quantitative instrument (i.e., a Q-sort survey) for the subsequent phase. The second pathway is the operationalization of the Q-sort survey results (i.e., implementation strategies) using an implementation science specification framework. Conclusion The pathway technique is valuable for mixed methods research and implementation science as it offers a theory-based innovative method to tackle integration challenge.
Small Monetary Incentives Lead to Greater Adherence in a Weight Loss Program
Authors: Shetty Armaan , Yang Qiuyu , Pendergast Jane , Leverson Glen , Shaw Ryan , Voils Corrine I. , Gavin Kara L. 
Published: November 2023

Purpose Understand how weekly monetary incentives for dietary tracking and/or weight loss impact 6-month weight loss behavioral adherence. Design Secondary analysis of participants randomized to one of four conditions in a behavioral weight loss intervention: incentives for dietary tracking, incentives for weight loss, both, or none. Setting Participants were asked to self-weigh at least twice weekly, log food and drink in a mobile application five days weekly, and attend bi-weekly, group-based classes. Sample Data from (n = 91) adults with obesity who completed a 24-week behavioral weight loss intervention of whom 88% were female and 74% Non-Hispanic White, were analyzed. Measures Non-adherence to weight and dietary self-monitoring was defined as the second week of not meeting criteria. Class attendance was also tracked. Analysis Kaplan-Meier analyses were used to examine differences across the four conditions. Results Participants incentivized for dietary self-monitoring had an average 15.8 weeks (SE:1.2) until the first non-adherent week compared to 5.9 weeks (SE:0.8) for those not incentivized for dietary self-monitoring ( P < .01). Those incentivized for weight loss had an average 18.0 weeks (SE:1.02) of self-weighing until the first non-adherent week compared to 13.5 weeks (SE:1.3) for those not incentivized for weight loss ( P = .02). No difference in class attendance was observed. Conclusions Incentivizing behaviors associated with weight loss improved adherence to those behaviors and does not appear to spill over to non-incentivized behaviors.
Classification of Listeria species using near infrared hyperspectral imaging
Authors: Matenda Rumbidzai T , Rip Diane , Williams Paul J 
Published: November 2023

Near infrared (NIR) hyperspectral imaging and multivariate data analysis was evaluated for its potential to detect and classify Listeria species. Three Listeria species, namely L. monocytogenes (ATCC 23074), L. innocua (ATCC 33090) and L. ivanovii (ATCC 19119) were grown for single colonies on Brain Heart Infusion agar and imaged in the NIR range of 950–2500 nm. Principal component analysis (PCA) was used for data exploration and to establish pattern recognition. Images were pre-processed with standard normal variate correction and the Savitzky-Golay smoothing technique (third order polynomial with 15 points). Two approaches to data analysis, that is object-wise and pixel-wise analysis, were investigated for discriminant analysis. The PCA score plot showed slight separation between the three groups with L. monocytogenes and L. ivanovii grouping close together. It was possible to visualise separation along PC3 (5.64% sum of squares (SS)) and PC4 (3.44% SS). Based on the loadings, differences in bacteria were attributed to teichoic acids, protein, and carbohydrate composition in the bacterial cell wall within the wavelength range 1000–1900 nm. Using extracted spectral data from the hypercubes, partial least squares discriminant analysis was employed for further classification. Classification accuracies above 90% were achieved for L. monocytogenes, L. innocua and L. ivanovii. This was true for data analysed using both pixel-wise analysis and object-wise analysis. The results demonstrated that hyperspectral imaging has notable potential to classify bacteria within the Listeria genus. Nonetheless, in order to improve model efficiency, model optimisation and incorporation of more bacterial strains need to be investigated in further research.
General practitioners’ attitudes and knowledge about attention-deficit hyperactivity disorder (ADHD): Insights from a survey
Authors: Kwon Susie , Bhurawala Habib , Munoz Anita , Kramer John , Poulton Alison 
Published: November 2023

Objective The Review of health services for children, young people and families within the NSW Health system identified that novel models of care were needed to improve access to clinical management for people with ADHD. The present study aimed to evaluate GPs’ knowledge of and attitudes towards ADHD and the challenges and opportunities for a more substantial role for GPs in ADHD management. Method An online survey of Australian GPs was conducted, with recruitment via email invitation. Results Out of 230 respondents, 213 surveys could be analysed. Of these, 97% believed ADHD was a genuine condition, with 90% identifying inattention as a primary symptom. Most (92%) had seen and diagnosed ADHD within the past year. Prevalent concerns included inadequate access to specialist assessment and treatment; 77% felt that GPs should have a more substantial role in ADHD management. Barriers included lack of time, knowledge and experience. Conclusions There was willingness amongst respondents take on a greater role in managing individuals with ADHD. However, a need for further training and education was highlighted. The Australian Evidence-Based Clinical Practice Guideline for ADHD may resolve an identified need for clinical guidance.