bluuebunny/crossref_metadata_2025_split huggingface dataset:
Designing a Systematic Experiment to Investigate the Effect of Ambient Smell on Human Emotions in the Indoor Space; Introducing a Mixed-Method Approach
Authors: Kafaei Mohsen , Burry Jane , Latifi Mehrnoush , Ciorciari Joseph 
Published: January 2024

AbstractStudies have indicated that built environments affect all aspects of human life such as emotion, perception, behavior, health, and well-being (Cooper et al. 2011). Built environments are formed from the combination and juxtaposition of visible and invisible environmental variables. In recent years, common techniques such as virtual reality, augmented reality, digital twins, and artificial intelligence have enabled researchers in the field of architecture and urban design to simulate environmental conditions to investigate the impacts of environmental variables on humans. However, the studies conducted in this field of human comfort are mostly focused on the impact of environmental variables such as form, temperature, humidity, and sound, and in fewer studies, up-to-date methods and technologies have been used to simulate and investigate the impact of smell on humans. Most of the studies that have investigated the effect of ambient smell on humans, carried out in the discipline of architecture and urban design, have used traditional tools and methods (questionnaire, interview, observation) rather than advanced technology and tools drawing on neuroscientific knowledge and technique to measure the effectiveness of the ambient smell on human. They have used unmasked scents or real-world environments rather than being able to simulate environmental conditions. This article highlights the significance and necessity of employing simulation methods to investigate the impact of environmental smells on humans. Additionally, it presents the methodology of an experiment for studying the effect of indoor environment smells (with a case study of an office environment in the initial phases) on human emotions, utilizing a mixed-method approach. Analysis of some parts of the data from this experiment showed that exposure to the fragrance of the jasmine flower pleasant (flower) and the odor of the rotten orange peel (unpleasant) can cause changes in the electroencephalography (EEG) power across different bands among participants.
Animate Concrete: Materialization of Concrete Element Kinetic Assemblies
Authors: Mehdizadeh Samim , Tessmann Oliver 
Published: January 2024

AbstractAnimate Concrete informs building elements for motion and future reuse. This paper gives technical insight into strategies to reconfigure building systems with lightweight and movable concrete elements. Animate Concrete asks, what if architecture becomes an ever-changing system built with lightweight but heavy-looking elements that can move, assemble and disassemble through a gentle human touch? This vision allows for a versatile space, adaptation, and reconfigurability. Animate Concrete furthermore seeks to provide novel strategies to minimize material consumption for building elements by rotoforming thereby significantly reducing the weight of robotically precast concrete elements.
Threading Cellular Architecture Geometries
Authors: González Alberto Fernandez , Karastathi Nikoletta 
Published: January 2024

AbstractIn the massive computer architecture known as cellular automata (CA), finite-state machines, also known as finite-state automata, are arranged in a discontinuous network that permits local interactions between neighbors. As self-organizing artificial systems, such as neural networks and genetic algorithms, developed from vast systems formed with essential elements and just local interactions, CA is mainly related to artificial intelligence (AI) (a seed interacts with its own neighbors, which are usually just the cells closer to the seed as an activator). In order to produce architectural spaces of various sizes, this research develops digital experiments that analyze the interactions between environmental conditions as input, CA as generator/propagator, and geometrical emergent patterns from knitting and weaving processes as translators/mediators. This method functions as a bottom-up strategy in which information from the environment can influence the activation and deactivation of rules, theoretically fostering a reprogrammable structure that can evolve.
An extremely rare serovar of Salmonella enterica (Yopougon) discovered in a Western Whip Snake (Hierophis viridiflavus) from Montecristo Island, Italy: case report and review
Authors: De Bene Andrea Francesco , Russini Valeria , Corradini Carlo , Vita Silvia , Pecchi Sabrina , De Marchis Maria Laura , Terracciano Giuliana , Focardi Claudia , Montemaggiori Alessandro , Zuffi Marco Alberto Luca , Weill François-Xavier , Bossù Teresa 
Published: January 2024

AbstractReptiles, including snakes, can be asymptomatically infected with multiple pathogen microorganisms, including Salmonella spp., which is considered an important concern for public and animal health. Small and uninhabited isles are quite ecologically different from mainland and represent interesting fields of study, to discover unexpected biological and microbiological aspects of their wild inhabitants. This work reports the presence of the very rare Salmonella enterica serovar Yopougon, isolated in a carcass of a native wild snake (Hierophis viridiflavus) from an Italian uninhabited island of Mediterranean Sea, Montecristo. To our knowledge, S. enterica serovar Yopougon was previously isolated only once 34 years earlier in Ivory Coast, from a human fecal sample. In the present study, we present the genomic characterization of the new isolate, the phylogenetic comparison with the previously isolated S. enterica serovar Yopougon strain of human origin and with other sequences available in public databases. In addition, an extensive review of available data in the literature and from our case history is provided. Our finding represents an example of the ability of some pathogens to travel for very long distances within their hosts and then to infect others, even from different taxa.
Standardisierte und qualitätsgesicherte prädiktive PD-L1-Testung im oberen Gastrointestinaltrakt
Authors: Baretton G. , Lordick F. ,   Die Interdisziplinäre Expertengruppe, Gaiser T. , Hofheinz R. , Horst D. , Lorenzen S. , Möhler M. , Röcken C. , Schirmacher P. , Stahl M. , Thuss-Patience P. , Tiemann K. 
Published: January 2024

ZusammenfassungInfolge der hohen Zulassungsdynamik sowie der wachsenden Anzahl an immunonkologischen Therapiekonzepten nimmt die Komplexität der Therapieentscheidung und -steuerung im Bereich der Karzinome des Ösophagus, gastroösophagealen Übergangs und Magens stetig zu. Da die Indikationsstellung bei den derzeit in der Europäischen Union zugelassenen PD-1-Inhibitoren häufig an die Expression von PD-L1 (Programmed Cell Death Ligand 1) gekoppelt ist, ist die Bestimmung dieses gewebebasierten prädiktiven Markers durch die Pathologie für die Stratifizierung der Behandlung von maßgeblicher Bedeutung. Auch wenn die immunhistochemische Bestimmung des PD-L1-Expressionsstatus zu den am besten untersuchten, therapierelevanten Biomarkern für eine immunonkologische Behandlung gehört, ergeben sich aufgrund der hohen Heterogenität der Karzinome des oberen Gastrointestinaltrakts im klinisch-diagnostischen Alltag Herausforderungen in Bezug auf die Implementierung, Standardisierung und Interpretation der Testung. Eine interdisziplinäre Expertengruppe aus Deutschland hat zu relevanten Fragen aus dem klinisch-pathologischen Alltag Stellung bezogen, die das Ausgangsmaterial, die qualitätsgesicherte Testung und die Befundinterpretation betreffen und Empfehlungen für eine strukturierte Befunderstellung erarbeitet.
Mosses recognized as glacial relicts from their postglacial distribution in Poland
Authors: Drzymulska Danuta 
Published: January 2024

AbstractSome glacial relict (mosses) have survived from the Ice Age up to the present time in specific, long-lasting habitats. Mires are one of the most common ecosystems in which they are present. In this paper the past distribution of eight species of such peat-forming mosses in Poland in the past is discussed. The distribution and dates of previously published moss finds in Poland have been mapped. In almost every case the largest number of places where they were found was in northern, or more precisely northeast Poland. A significant difference in the number of known find sites for individual species and many sites of unknown age were found. The rarest moss was definitely Cinclidium stygium and the most frequent was Meesia triquetra. Data on the distribution of mosses in the Late Glacial and Holocene proved to be scarcer than expected. Only a few sites were found where the occurrence of species such as Meesia triquetra, Calliergon giganteum, Tomentypnum nitens, Pseudocalliergon trifarium, Helodium blandowii and Scorpidium scorpioides was fairly continuous for this period. Therefore, the status of these mosses as glacial relicts seems to merit some thought. Certainly, there is a further need for high resolution research on bryophyte macrofossils, combined with accurate dating.
Real-time cardiovascular magnetic resonance imaging for non-invasive characterisation of heart failure with preserved ejection fraction: final outcomes of the HFpEF stress trial
Authors: Backhaus Sören J. , Schulz Alexander , Lange Torben , Schmidt-Schweda Lennart S. , Evertz Ruben , Kowallick Johannes , Hasenfuß Gerd , Schuster Andreas 
Published: January 2024

Abstract
Background
The diagnosis of heart failure with preserved ejection fraction (HFpEF) remains challenging. Recently, the HFpEF Stress Trial demonstrated feasibility and accuracy of non-invasive cardiovascular magnetic resonance (CMR) real-time (RT) exercise-stress atrial function imaging for early identification of HFpEF. However, no outcome data have yet been presented.

Methods
The HFpEF Stress Trial (DZHK-17) prospectively recruited 75 patients with dyspnea on exertion and echocardiographic preserved EF and signs of diastolic dysfunction (E/eʹ > 8). 68 patients entered the final study cohort and were characterized as HFpEF (n = 34) or non-cardiac dyspnea (n = 34) according to pulmonary capillary wedge pressure (HFpEF: PCWP rest: ≥ 15 mmHg stress: ≥ 25 mmHg). These patients were contacted by telephone and hospital charts were reviewed. The clinical endpoint was cardiovascular events (CVE).

Results
Follow-up was performed after 48 months; 1 patient was lost to follow-up. HFpEF patients were more frequently compared to non-cardiac dyspnea (15 vs. 8, p = 0.059). Hospitalised patients during follow-up had higher H2FPEF scores (5 vs. 3, p < 0.001), and impaired left atrial (LA) function at rest (p ≤ 0.002) and stress (p ≤ 0.006). Impairment of CMR-derived atrial function parameters at rest and during exercise-stress (p ≤ 0.003) was associated with increased likelihood for CVE. CMR-Feature Tracking LA Es/Ee (p = 0.016/0.017) and RT-CMR derived LA long axis strain (p = 0.003) were predictors of CVE independent of the presence of atrial fibrillation.

Conclusions
Left atrial function emerged as the strongest predictor for 4-year outcome in the HFpEF Stress Trial. A combination of rest and exercise-stress LA function quantification allows accurate diagnostic and prognostic stratification in HFpEF.
Clinicaltrials.gov: NCT03260621.

Graphical abstract
Wasteaware adaptation to the context of a Latin American country: evaluation of the municipal solid waste management in Cali, Colombia
Authors: Giraldo-Almario Isabela , Rueda-Saa German , Uribe-Ceballos Jose Reinel 
Published: January 2024

AbstractAccording to the World Bank report, Colombia generated 5.6% (13 million tons per year) of municipal solid waste in Latin America and the Caribbean in 2016. About 30% of this waste came from the three main cities of the country, Bogotá, Medellín, and Cali. Evaluation of the performance of municipal solid waste management systems is important for reducing environmental and public health impacts in cities. Wasteaware benchmark indicators have been used worldwide for monitoring those systems. The results of the adaptation of this methodology to the Context of a Latin American Country are presented in this research. The solid waste comprehensive management policy and regulatory framework in Colombia were considered. As a case study, the adaptation of Wasteaware was implemented using the data from the Cali solid waste management system for 2019. The results of the evaluation for Cali indicate that system presents a high overall performance (91%). Cali achieved the highest performance when compared to other Latin American cities. The implementation of this management instrument in Colombian cities will provide sufficient and relevant information regarding the municipal solid waste management systems. It is expected that this initiative will be replicated in other cities in Latin America.
Search-based Automatic Repair for Fairness and Accuracy in Decision-making Software
Authors: Hort Max , Zhang Jie M. , Sarro Federica , Harman Mark 
Published: January 2024

AbstractDecision-making software mainly based on Machine Learning (ML) may contain fairness issues (e.g., providing favourable treatment to certain people rather than others based on sensitive attributes such as gender or race). Various mitigation methods have been proposed to automatically repair fairness issues to achieve fairer ML software and help software engineers to create responsible software. However, existing bias mitigation methods trade accuracy for fairness (i.e., trade a reduction in accuracy for better fairness). In this paper, we present a novel search-based method for repairing ML-based decision making software to simultaneously increase both its fairness and accuracy. As far as we know, this is the first bias mitigation approach based on multi-objective search that aims to repair fairness issues without trading accuracy for binary classification methods. We apply our approach to two widely studied ML models in the software fairness literature (i.e., Logistic Regression and Decision Trees), and compare it with seven publicly available state-of-the-art bias mitigation methods by using three different fairness measurements. The results show that our approach successfully increases both accuracy and fairness for 61% of the cases studied, while the state-of-the-art always decrease accuracy when attempting to reduce bias. With our proposed approach, software engineers that previously were concerned with accuracy losses when considering fairness, are now enabled to improve the fairness of binary classification models without sacrificing accuracy.
Study of the effect of keap1 on oxidative stress in human umbilical cord mesenchymal stem cells
Authors: Deng Hongrong , Chen Yunxia , Liu Huiwen , Wang Li , Xu Hao , Tan Bin , Yi Qin , Wang Rui , He Bolin , Tian Jie , Zhu Jing 
Published: January 2024

Abstract

Background
HucMSCs had shown promising efficacy in treating childhood diseases, but oxidative stress induced by the poor microenvironment at the site of damage resulted in low cell survival after transplantation, thus preventing the cells from maximizing therapeutic efficacy. Therefore, this study aimed to investigate the role and mechanism of keap1 in oxidative stress injury of human umbilical cord mesenchymal stem cells (hucMSCs), and to provide theoretical support for improving the efficacy of stem cell therapy.

Methods
The hucMSCs were treated with hypoxic low-sugar-free serum (GSDH) to mimic the damaged site microenvironment after implantation. Adenoviral overexpression of keap1 gene of hucMSCs was performed in vitro, and cell proliferation ability was detected by CCK8 assay, crystal violet staining assay, and cell cycle assay. Cellular redox level was assessed by Amplex Red, MDA, and GSH/GSSG kit. Mitochondrial morphology was evaluated by mitotracker Red staining. ATP production was estimated by ATP detection kit. The mRNA and protein expression levels were tested by western blotting and RT-qPCR.

Results
GSDH treatment substantially upregulated keap1 expression. Subsequently, we found that overexpression of keap1 notably inhibited cell proliferation and caused cells to stagnate in G1 phase. At the same time, overexpression of keap1 induced the production of large amounts of H2O2 and the accumulation of MDA, but suppressed the GSH/GSSG ratio and the expression of antioxidant proteins NQO1 and SOD1, which caused oxidative stress damage. Overexpression of keap1 induced cells to produce a large number of dysfunctional mitochondria resulting in reduced ATP production. Moreover, Overexpression of keap1 significantly decreased the IKKβ protein level, while upregulating IkB mRNA levels and downregulating P50 mRNA levels.

Conclusions
Overexpression of keap1 may induce oxidative stress injury in hucMSCs by down-regulating IKKβ expression and inhibiting NF-κB pathway activation. This implies the importance of keap1 in hucMSCs and it may be a potential gene for genetic modification of hucMSCs.
Marian Zdziechowski’s work On Cruelty (1928–1938). Between past and present
Authors: Przebinda Grzegorz 
Published: January 2024

AbstractThe following article begins with my recollection of the only academic conference on Zdziechowski that was organised still under the communist regime in the autumn of 1984 at the Jagiellonian University and ends with a description of the discussion on the genesis and power of evil, with the participation of Czesław Miłosz and Leszek Kołakowski, which was triggered in Poland immediately after the publication of the last edition of On Cruelty in 1993. On Cruelty was first published in 1928 in the journal Przegla̧d Współczesny [Contemporary Review] in Krakow, a second time in 1938 in the volume of articles In the Face of the End, Krakow 1938, and a third – and so far last – time also in Krakow in 1993. On Cruelty, published three times but so far only in Polish, has never been thoroughly analysed or even discussed, which is why this article focuses on discussing it and related questions about the origins and nature of evil, mainly in Europe and Asia, from the earliest times to the present. Zdziechowski was particularly outraged when the cruelty he condemned was justified by religion, especially Christianity (Catholic and Protestant). From these condemnations, he described the activities of the Inquisition, the witch trials, cruelty to animals, and – in the introduction – the “psychology of cruelty.” At the same time, however, he meticulously listed the names of those political and spiritual leaders in Europe and Asia, theologians and thinkers, who, over many centuries, up to the present day, have resolutely spoken out against evil, including cruelty, within and outside the Church. A separate and important issue is Zdziechowski’s attitude to Tsarist Russia and Bolshevism, as outlined in his work On Cruelty. On the one hand, he pointed out that at least two rulers of Russia before 1917 – Ivan the Terrible and Peter the Great – had made major contributions to the history of cruelty in Europe and Asia. But Bolshevism, which Zdziechowski condemned in the strongest terms, was in his eyes not a continuation of pre-1917 Russian despotism, but emanated from the depths of Asia.
A Detailed Study of Boiling Phenomena in Forced Convective Quenching Experiments
Authors: Cruces-Reséndez R. , Hernández-Morales B. , Guzmán J. E. V. 
Published: January 2024

AbstractA detailed study at the microscopic level of the transient behavior of boiling phenomena during quenching of an AISI 304 stainless steel, conical-end, cylindrical probe in flowing water at 60 °C was conducted using high-speed video recordings and cooling curve data acquisition. Two free-stream velocities (0.2 and 0.6 m/s) and two initial probe temperatures (850 and 950 °C) were investigated. It was complemented by video recordings at 60 fps to calculate the wetting front velocity. Surface heat flux histories at the thermocouple positions were estimated by solving the corresponding Inverse Heat Conduction Problem. As the water velocity increases the duration of the vapor film at each thermocouple position shortens and the difference among cooling curves at the thermocouple positions decreases. Increasing the initial temperature increases the duration of the vapor film stage. The wetting front velocity increased from 4 to 6 m/s. The time to reach the maximum surface heat flux at the position of the thermocouple closest to the probe tip ranged from 9.7 to 18 s. Undulations at the vapor-liquid interface that appear periodically and propagate in the direction of quenchant flow were observed early during the vapor film stage. Later, before the collapse of the vapor film, a kind of a shock wave was generated at the probe tip which modified the appearance of the film. Once the Leidenfrost temperature is reached, a wetting front (which consists of many small bubbles that coalesce rapidly in a very small area) is formed and travels in the direction of quenchant flow while fewer and larger bubbles nucleate and grow upstream. The nucleation, growth and detachment of the larger bubbles was studied; as the free-stream velocity decreases larger values of bubble maximum diameter and half-life time were observed, while the initial temperature has a marginal effect on these quantities.
Hydrophobic phytic acid conversion layers for corrosion protection of steel surfaces
Authors: Weinert Michelle , Gutmann Jochen S. , Dornbusch Michael 
Published: January 2024

AbstractThe possibility for a good conversion protection based on phytic acid (PA) solutions is described many times in the literature.1,2 The latest results show that PA cannot improve the corrosion protective properties with an organic coating,2 although PA conversion layers without organic coatings have already successfully been applied on different surfaces and the development of layers with enhanced corrosion protective behavior was possible.3,4 The reason why PA does not work together with an organic coating is based on the hydrophilic surface and therefore the low contact angle of the PA conversion layer.2 One solution is to modify PA directly and/or change the solution properties to increase the hydrophobic properties. In this work, a new and innovative way to synthesize a new type of sustainable organic PA-based conversion layers on steel, which works completely without titanium or zirconium and is a new approach for hydrophobic conversion layers, is presented.5 The results prove the formation of a pure PA-based conversion layer on the surface. The infrared (IR), Raman, and nuclear magnetic resonance (NMR) spectroscopy verified the new synthesis products and by means of the vibration spectroscopy, the resulting conversion layers. To analyze the new physical properties, the contact angle of the conversion layers was detected. By means of the electrochemical impedance spectroscopy (EIS), the electrochemical stability of the conversion was studied and with cyclic voltammetry (CV), the solidity ratio was investigated. At last, the corrosion protective performance of the layers in combination with an E-coat in the salt spray test (SST) was examined. All modified PA-based conversion layers in combination with E-coats increased the corrosion protective properties in relation to industrial used phosphate conversion layers of steel surfaces. The overall result is a new kind of hydrophobic phytic acid-based conversion layer which shows advanced anticorrosion and coatability properties compared to other layers based on PA. The results if the EIS measurements show that the resistance of the coating significantly increased, and diffusion could be suppressed by coating the metal surface with PA conversion layers. The comparison of the SST results for the reference and the modified PA underline these observations. The overall SST rating increased by 2 and the delamination went down to 1.9 mm while the corrosion was 0.1, comparable to phosphated steel.