bluuebunny/crossref_metadata_2025_split huggingface dataset:
Low-coverage whole genome sequencing of low-grade dysplasia strongly predicts advanced neoplasia risk in ulcerative colitis
Authors: Al Bakir Ibrahim , Curtius Kit , Cresswell George D , Grant Heather E , Nasreddin Nadia , Smith Kane , Nowinski Salpie , Guo Qingli , Belnoue-Davis Hayley L , Fisher Jennifer , Clarke Theo , Kimberley Christopher , Mossner Maximilian , Dunne Philip D , Loughrey Maurice B , Speight Ally , East James E , Wright Nicholas A , Rodriguez-Justo Manuel , Jansen Marnix , Moorghen Morgan , Baker Ann-Marie , Leedham Simon J , Hart Ailsa L , Graham Trevor A 
Published: January 2025

BackgroundThe risk of developing advanced neoplasia (AN; colorectal cancer and/or high-grade dysplasia) in ulcerative colitis (UC) patients with a low-grade dysplasia (LGD) lesion is variable and difficult to predict. This is a major challenge for effective clinical management.ObjectiveWe aimed to provide accurate AN risk stratification in UC patients with LGD. We hypothesised that the pattern and burden of somatic genomic copy number alterations (CNAs) in LGD lesions could predict future AN risk.DesignWe performed a retrospective multicentre validated case–control study using n=270 LGD samples from n=122 patients with UC. Patients were designated progressors (n=40) if they had a diagnosis of AN in the ~5 years following LGD diagnosis or non-progressors (n=82) if they remained AN-free during follow-up. DNA was extracted from the baseline LGD lesion, low-coverage whole genome sequencing performed and data processed to detect CNAs. Survival analysis was used to evaluate CNAs as predictors of future AN risk.ResultsCNA burden was significantly higher in progressors than non-progressors (p=2×10−6in discovery cohort) and was a very significant predictor of AN risk in univariate analysis (OR=36; p=9×10−7), outperforming existing clinical risk factors such as lesion size, shape and focality. Optimal risk prediction was achieved with a multivariate model combining CNA burden with the known clinical risk factor of incomplete LGD resection. Within-LGD lesion genetic heterogeneity did not confound risk prediction.ConclusionMeasurement of CNAs in LGD is an accurate predictor of AN risk in inflammatory bowel disease and is likely to support clinical management.
Complex high-risk indicated PCI (CHIP-PCI): is it safe to let fellows-in-training perform it as primary operators?
Authors: Protty Majd B , Hasan Saad , Premawardhana Diluka , Addin Mohammed Shugaa , Morgan Holly , Bundhoo Shantu , Hussain Hussain , Ul-Haq Zia , Chase Alexander , Hildick-Smith David , Choudhury Anirban , Kinnaird Tim , Hailan Ahmed 
Published: January 2025

BackgroundTraining in complex high-risk indicated percutaneous coronary intervention (CHIP-PCI) has frequently been reserved for established operators (consultants/attending) with trainees (fellows-in-training or FIT) being often discouraged from carrying out such procedures as a primary operator due to their high-risk nature. Whether the outcomes of these cases differ if the primary operator is a supervised FIT compared with a consultant is unknown.MethodsUsing multicentre PCI data from three cardiac centres in South Wales, UK (2018–2022), we identified 2295 CHIP-PCI cases with a UK-BCIS CHIP Score of 3 or more. These were then divided by primary operator status (supervised FIT vs consultant); the primary outcome was in-hospital major adverse cardiac events (IH-MACCE). Multivariate logistic models were developed to adjust for differences in baseline and procedural characteristics.ResultsThe primary operator in 838 (36%) of the PCIs was a supervised FIT. Baseline and procedural characteristics had lower complexity in CHIP-PCI cases carried out by supervised FIT vs consultant. In a multivariate-adjusted model, supervised FIT procedures were associated with lower odds of concurrent valve disease (OR 0.45, 95% CI: 0.29 to 0.69), dual access (OR 0.58, 95% CI: 0.41 to 0.83), cutting/scoring balloons (OR 0.59, 95% CI: 0.44 to 0.79) and rotational atherectomy (OR 0.60, 95% CI: 0.42 to 0.87). After adjusting for all variables, however, there was no difference in the primary outcome (OR 0.72, 95% 0.34 to 1.51) or any secondary outcomes. Sensitivity analyses restricted to patients with higher CHIP Scores (4+ and 5+) showed comparable IH-MACCE.ConclusionsTraining FIT as primary operators in CHIP-PCI appears to be feasible and safe and can be delivered within the standard training programme. The comparable outcomes are likely driven by the two-operator ‘buddy’ effect that a FIT supervised by a consultant benefits from.
The structure of learners’ perceptions of models (not only) in quantum physics: spotlight on Fidelity of Gestalt and Functional Fidelity
Authors: Bitzenbauer Philipp , Ubben Malte S. 
Published: January 2025

Abstract
In previous research, it has been argued that many of the student (mis-)conceptions of quantum concepts described in the literature as widespread among learners can be traced back to poorly developed (quantum) model perceptions that hinder the learning of quantum physics. In particular, it has been shown that the degrees of two cognitive dimensions, namely Functional Fidelity and Fidelity of Gestalt, in students’ thinking account for a substantial amount of the variance in students’ model perceptions in quantum physics and may therefore be useful for describing and understanding the (development of) students’ conceptions of quantum physics topics. So far, however, the cognitive dimensions Functional Fidelity and Fidelity of Gestalt have only been investigated in exploratory studies. In this article, we report the results of a confirmatory factor analysis of data collected from N = 179 secondary school students using an instrument adapted from the literature to assess learners’ perceptions of the photon model. The results of our study provide empirical evidence that the two-factor model of learners’ model perceptions in the quantum context is indeed a good fit to the data. Together with literature from science education research on students’ conceptual development, and taking into account earlier findings on Fidelity of Function and Gestalt Fidelity we derive a plausible description of students’ conceptual development in the context of quantum physics – leading to what we call the Fidelities-Model of Conceptual Development. We discuss this framework in the light of previous research and argue for its potential generalisability beyond the teaching and learning of quantum physics topics. The implications of our findings for both science education research and practice are presented.
Entry Deregulation, Market Turnover, and Efficiency: China's Business Registration Reform
Authors: Barwick Panle Jia , Chen Luming , Li Shanjun , Zhang Xiaobo 
Published: January 2025

Abstract
Although entry regulations are ubiquitous across countries, comprehensive evaluations on how such regulations affect firm dynamics and productivity are lacking. We examine a 2012-2014 pilot program in Guangdong (which later became a national policy) that was designed to reduce firm registration costs and encourage entrepreneurial activities. Using administrative data on firms' business registrations and annual reports, our analysis shows that the reform increased firm entry by 25% and firm exit by 8.7% in the manufacturing sector. The productivity of post-reform entrants was 1.1% higher than the productivity of pre-reform entrants, likely due to relaxed financial constraints and more intense competition.
Design of Partial Population Experiments with an Application to Spillovers in Tax Compliance
Authors: Cruces Guillermo , Tortarolo Dario , Vazquez-Bare Gonzalo 
Published: January 2025

Abstract
We develop a framework to analyze partial population experiments, a generalization of the cluster experimental design where clusters are assigned to different treatment intensities. Our framework allows for heterogeneity in cluster sizes and outcome distributions. We study the large-sample behavior of OLS estimators and cluster-robust variance estimators and show that (i) ignoring cluster heterogeneity may result in severely underpowered experiments and (ii) the cluster-robust variance estimator may be upward-biased when clusters are heterogeneous. We derive formulas for power, minimum detectable effects, and optimal cluster assignment probabilities. All our results apply to cluster experiments, a particular case of our framework. We set up a potential outcomes framework to interpret the OLS estimands as causal effects. We implement our methods in a large-scale experiment to estimate the direct and spillover effects of a communication campaign on property tax compliance. We find an increase in tax compliance among individuals directly targeted with our mailing, as well as compliance spillovers on untreated individuals in clusters with a high proportion of treated taxpayers.
Flexing Armageddon: Displacing Climate Change Anxiety through Soft Power Nationalist Interests in Guo Fan’s The Wandering Earth (2019)
Authors: Christopher David 
Published: January 2025

Abstract
In recent years, apparently as part of the public relations for its global “soft power” initiatives, China has moderately relaxed much of its previously archaic policy control of its cinema production industry. One result has been the release of a spate of Chinese films to international streaming platforms such as Netflix. One highly visible example is Guo Fan’s The Wandering Earth (2019), a pre-pandemic apocalypse film that unabashedly appropriates conventions from the raft of fin-de-millenaire Hollywood apocalypse films such as Michael Bay’s Armageddon (1998) as part of China’s political economy bid to enter into the international cinematic market. But is it as simple as all that? While films such as The Wandering Earth represent a welcome diversification of more international fare on such giant media streaming platforms as Netflix, and give international exposure to such talented Chinese directors as Guo Fan, the particular ideological project of the film should not go unnoticed. While critics such as Petrus Liu (2020), Laura Waisbich (2020), Ping Zhu (2020), and Amir Khan (2020) have noted the film as an allegory of catastrophic climate change, and Petrus Liu (2020) and Jeroen de Kloet (2022) have noted its similarity to Armageddon in particular, the specific ideological projects of the displacement of techno-industrial responsibility for catastrophic climate change in concert with a “soft power” competition with U.S. hegemony in the context of what Chris Berry (2021) refers to as the phenomenon of “two globalizations” has not been clearly articulated. When compared against Armageddon in particular, it becomes clear how the film works to displace climate change responsibilities in a soft power ideological gambit against U.S. global-capitalist hegemony. Thus, the project of this article is to explore how The Wandering Earth narratively raises the stakes on a similar American ideological project in such spectacular Hollywood films as Michael Bay’s Armageddon, in particular, for example, and resolves contemporary issues of eco-catastrophe with a melodramatic tale of xenophobic Chinese patriarchal salvation that supersedes the American originals in a “soft power” gambit for global hegemony.
Uncovering the Migration of Illicit Cultural Production: a Digital Ethnography of the jav Industry and Fan Communities in China
Authors: Zhang Xiaolong 
Published: January 2025

Abstract
While many studies have examined Japan’s cultural industries, including manga, anime, video games, and films, few have focused on the Japanese Adult Video (jav) industry. The limited research on pornography represents a critical omission given the widespread popularity of such content among the global youth and the imperative to comprehend the migration patterns of problematic or illicit cultural production across borders. The paper takes the example of the jav industry in China by adopting digital ethnography to illustrate the migration of such cultural production, where a government crackdown on pornography has led to Chinese fans becoming the primary cultural actors responsible for reproducing, distributing, and consuming javs. The absence of producers and intermediaries in this system implies that the state has eliminated any legitimate channels for producing and distributing adult entertainment content. The circulation of pornography is prohibited in China, which results in related materials being distributed through covert and challenging-to-regulate channels, such as seeds of the Magnet uri scheme and/or BitTorrent. Consequently, a group of enthusiastic pornography fans has surfaced on various platforms to share and exchange their materials. Therefore, this study has decided to start with the fan group to investigate the jav’s journey in China. By examining the hierarchy of jav fan communities in the Chinese online context, the study suggests that external pressure from government crackdowns on pornographic materials has led to increased solidarity and harmony among Chinese jav fans within their communities through politeness strategies and comradeship, which further weakened the hierarchy of fan communities. Additionally, the analysis of the popularity of Aoi Sora in China as a porn actress provides insight into the intricate mechanisms of cultural production and consumption.
A Uniquely Transnational Style: Bong Joon-ho’s Memories of Murder and The Host
Authors: Eason Emily 
Published: January 2025

Abstract
The Korean filmmaker Bong Joon-ho has constructed a uniquely transnational style through creating a discourse of the hybridization of South Korean and Hollywood cinemas. The development of this unique style is understood through two of Bong’s first feature films, Memories of Murder [Sarinui Chueok] (South Korea, dir: Bong, 2003) and The Host [Gwoemul] (South Korea and Japan, dir: Bong, 2006). These films demonstrate Bong’s ability to merge distinctly recognisable cinematic traditions from their respective nation. This merging is understood through what Marwan Kraidy (2002) refers to as “hybridization,” the films are analysed through three primary avenues (1) cultural, (2) political, and (3) visual. Bong’s subversion and repurposing of Hollywood conventions lies at the heart of his unique style and underpins his international success. This article reaffirms Bong’s place as a key transnational director who has the capacity to create Hollywood-style blockbusters which resonate politically and socially with their respective audiences.
Cultural Heritage and Chinese Digital Games
Authors: Aroni Gabriele 
Published: January 2025

Abstract
Digital games history has been dominated by Japan, North America, and Europe, both as major producers and consumers of games. However, China is now by far the largest digital games market on the planet, both in terms of player numbers and expenditure. This exceptional growth is naturally reflected in the local production of games, which, despite their large numbers and player base, are only now having more resonance in the West. This paper examines what role Chinese cultural heritage plays in the characterization of its games, as well as the similarities and differences with the Western and Japanese traditions of game arts and development, both from a ludological and aesthetic point of view, with a focus on the role-playing genre.
The Foreigner Indie Video Game Community in Japan from Tokyo Indies to Bitsummit
Authors: Maiuga Alexandra 
Published: January 2025

Abstract
Indie games are a relatively novel phenomenon in the Japanese video game industry. Despite a rich history of hobbyist games and dōjn communities, the development of the indie scene was hindered by social and political factors. How indie, as a genre, became prominent in Japan can be better explained by exploring the foreigner communities of indie developers. Indie communities appeared at the beginning of the 2010s as grassroots events organised by homesick foreigners. Despite linguistic barriers they built a flourishing indie scene that welcomes both Japanese and foreigners and helped create a mediator between local developers and Western markets through Bitsummit and Tokyo Indies. This article explores the involvement of foreigners in the popularization of the indie games by analyzing twelve interviews with foreigners involved in all areas of game development. It then contextualizes their experiences by introducing the role and history of Kyoto Indies, Tokyo Indies and Bitsummit and their complicated relationship with the mainstream Japanese video game industry.
Dreaming of a diy Career: Platform Practices, Motivational Discourses, and the Self-Entrepreneurial diy of Up-and-Coming Indie Bands in China
Authors: Vierbergen Mick 
Published: January 2025

Abstract
While China’s platformised cultural industries promote musical entrepreneurism, up-and-coming indie bands in China face several challenges in their journey towards a career in the music industries: a high regulatory threshold for participating in the live scene, little space for live experimentation, limited choice of online self-releasing platforms, and a censorship regime that limits criticism and creativity. This paper examines how up-and-coming indie bands, often overlooked in academia, navigate the precarious and competitive environment of professionalisation and regulation in China’s platformised music industry. Drawing on ethnographic methods and discourse analysis, it investigates the platform practices and motivations of three up-and-coming indie bands based around Shanghai: Protostar, Acid Room, and Blue Liquid. The paper identifies six discursive repertoires that these bands use to motivate their approach to a diy ethos – entrepreneurism, professionalism, authenticity, independence, convenience, and necessity – and argues that they adopt a self-entrepreneurial diy approach to actively shape their career.
Intermediating White Snake and Beyond: The Contingent Trans-Asian Journeys of Chinese Animation into Japan
Authors: Mihara Ryotaro , Yamashita Kazuo , Yoshikawa Tatsuo 
Published: January 2025

Abstract
This paper highlights cultural intermediaries as an indispensable analytical focus through which we could make intellectual sense of cultural production in East Asia and its global journeys. The existing literature recognises cultural intermediaries as critical agents who orchestrate a match between cultural products and their target markets. Examining cultural intermediaries in the realm of the growing inflow of Chinese animation into Japanese theatrical distribution nowadays, including the introduction of White Snake in Japan in 2021, this paper suggests contingency as one of the most critical features entailed in the work of cultural intermediaries. Our cases highlight how their intermediation process was, in fact, ignited and carried out in an immensely contingent manner without any pre-established plans or principles. The paper underscores contingency as the feature that deserves straightforward attention of the literature on cultural intermediaries, and as the vantage point from which we could make rich sense of the front-line dynamism at work in trans-Asian cultural productions.
Where Do Clients Receive Methadone Treatment? Exploring Bypassing Behaviors in Methadone Treatment Clients: Temporal, Geographic, and Demographic Factors
Authors: Alibrahim Abdullah , Marsh Jeanne C , Amaro Hortensia , Kong Yinfei , Khachikian Tenie , Guerrero Erick 
Published: January 2025

Background: Few studies have examined where clients receive methadone treatment for opioid use disorder relative to their residences. Commuting time affects access to care, and anecdotal evidence suggests clients often bypass closer methadone providers. This study quantifies (a) bypass patterns in Los Angeles County, (b) gender, age, and ethnoracial differences in bypassing, and (c) links between bypassing and facility attributes. Methods: Using retrospective multiyear analysis, we matched opioid treatment episodes with commuting times between clients’ ZIP codes and treatment facilities. From 16 972 outpatient episodes (2010-2017), data were paired with Google Maps commuting estimates. The study covered 32 methadone facilities and 8627 unique clients. We determined the difference in driving time (a proxy for commuting time) from the nearest (bypassed) provider to the provider where the client was treated, deriving bypass and extended commute rates. We compared the rates of a scaled bypassing variable across racial, ethnic, and gender groups. We examined rates by grouping and by facility characteristics of the closest provider. Results: Bypassing occurred in 48.9% of episodes; 21.0% involved extra commute time of 5+ minutes beyond the closest facility. Bypass rates varied significantly across racial, ethnic, and gender groups. Black or African American clients showed higher bypass rates than non-Latino white clients. Latino female clients had lower rates and shorter commutes than Latino male clients ( P < .01). Larger methadone facilities experienced fewer bypassing and Black clients were found to typically bypass in favor of providers with longer wait times than other groups in the study. Implications: This is the first study investigating client and facility characteristics relating to methadone treatment bypassing in a major U.S. care system. The results highlight significant bypass rates affecting efficient access. Findings have implications for opioid treatment system design, particularly to improve access to quality care for underserved communities.