bluuebunny/crossref_metadata_2025_split huggingface dataset:
Aerobic exercise to alleviate primary dysmenorrhea in adolescents and young women: A systematic review and meta‐analysis of randomized controlled trials
Authors: Cai Jingjie , Liu Mingyi , Jing Yan , Yin Zikang , Kong Nianxin , Guo Chenggen 
Published: January 2025

AbstractIntroductionAerobic exercise has been confirmed to alleviate primary dysmenorrhea (PD) in adolescents and young women. However, the effect of the aerobic exercise type and dosage on PD alleviation was unclear. This research aims to assess the effect of aerobic exercise on PD and investigate the dose–response relationships.Material and MethodsSystematic literature searches of Web of Science, Embass, Cochrane Library, PubMed, PsycNET, CINAHL, CNKI, Baidu Scholar, Google Scholar, and other Complimentary Medicine Database. PICOS standards were adopted in this research: participants were nonathlete women with PD; intervention was aerobic exercise of at least one menstruation cycle; comparator was any comparator; outcomes were pain intensity or pain duration; and study type was randomized controlled trials. The Cochrane Collaboration risk of bias tool was used to assess the quality of the research. Random‐effect meta‐analysis was conducted for pain intensity and pain duration, with prespecified subgroup analyses based on aerobic exercise components. The strength of the evidence was assessed using GRADE. This systematic review and meta‐analysis was registered in PROSPERO (CRD42024533544).ResultsThe study identified 16 eligible studies, with 15 involving adolescents, totaling 918 participants aged 15 to 43, with an average age of 21.26 ± 13.15. The results confirmed that aerobic exercise can alleviate PD's pain intensity (standard mean difference (SMD) = −1.728 (p = 0.00), 95% CI [−2.26 to −1.31]) and pain duration (weighted mean difference (WMD) = −12.53 h, p = 0.01, 95% CI: −21.38 to −3.68). However, the heterogeneity of these two results was high. Subgroup analysis showed that Pilates (SMD = −3.17, 95% CI [−4.26 to −2.07]), low intensity (SMD = −1.64, 95% CI [−2.10 to −1.19]), 31–45 min duration (SMD = −3.05, 95% CI [−5.36 to −0.75]), ≤2 times per week frequency (SMD = −2.24, 95% CI [−3.36 to −1.12]), and a period cycle of 2 menstrual cycles (SMD = −2.21, 95% CI [−3.13 to −1.28]) had the maximum effect size.ConclusionsAerobic exercise was able to alleviate pain intensity and pain duration in adolescents and young women with PD. Moderate‐quality evidence indicates that Pilates, low intensity, 46–60 min, ≤two times per week, or two menstrual cycles showed more efficiency in alleviating PD. Due to the limited data, future research should prioritize conducting randomized controlled trials of aerobic exercise interventions in younger age groups to develop personalized treatment strategies for adolescents.
Effect of panretinal photocoagulation on retinal oxygen metabolism and ocular blood flow in diabetic retinopathy
Authors: Abu El‐Asrar Ahmed M. , Alsarhani Waleed K. , AlBloushi Abdulrahman F. , Alzubaidi Abdullah , Gikandi Priscilla , Stefánsson Einar 
Published: January 2025

AbstractPurposeTo investigate the effects of panretinal photocoagulation (PRP) on retinal oxygen metabolism, calibre of retinal vessels, and blood flow velocity in the optic nerve head (ONH) and choroid in patients with severe nonproliferative diabetic retinopathy (NPDR) and proliferative diabetic retinopathy (PDR).MethodsIn this retrospective study, 37 patients (37 eyes) were studied. Retinal oximetry and laser speckle flowgraphy measurements were performed at baseline and after PRP.ResultsAfter PRP, oxygen saturation of retinal arterioles (p = 0.003) and arteriovenous oxygen saturation difference (p = 0.005) significantly increased. On the other hand, the calibre of retinal arterioles significantly decreased (p = 0.016). In the ONH, mean blur rate (MBR)‐vessel (p = 0.002), representing blood flow velocity in the retinal vessels, and MBR‐tissue (p = 0.002), representing ONH blood flow velocity, and choroidal MBR (p = 0.012) significantly decreased. At baseline, there were significant negative correlations between ONH MBR‐overall (r = −0.382, p = 0.026) and ONH MBR‐tissue (r = −0.455, p = 0.007) and arteriovenous oxygen saturation difference. After PRP, choroidal MBR had a significant negative correlation with arteriolar oxygen saturation (r = −0.415, p = 0.016).ConclusionsThe effects of PRP are correlated with increased arteriovenous oxygen saturation difference, reduction in the calibre of retinal arterioles, and reduction of retinal and choroidal blood flow velocities.
Management of Neonatal Hyperglycaemia in Sweden—A Survey Study
Authors: Frithiof Ludvig Henriksson , Domellöf Magnus , Zamir Itay Nilsson 
Published: January 2025

ABSTRACTAimNeonatal hyperglycaemia is associated with a multitude of adverse outcomes, including mortality and impaired neurological development. The aim of this study was to characterise the current management of neonatal hyperglycaemia in Swedish neonatal units.MethodsA digital survey was sent to 27 Swedish neonatal units providing care to preterm infants born before 32 completed gestational weeks.ResultsSixty‐eight responses were collected from 21 different units. Thirty‐two percent (22/68) of clinicians reported having a local treatment guideline for neonatal hyperglycaemia. Hyperglycaemia was defined as a glucose concentration above a value in the range of 8.0–10.0 mmol/L by 62.5% of clinicians, while 16.7% and 21.8% used a definition between 10.1 and 12.0 mmol/L and > 12 mmol/L, respectively. Intravenous glucose reduction was initiated at higher glucose concentrations by clinicians working at university hospital units (p = 0.006). Glucose concentration threshold for initiation of insulin treatment varied between 8 and 30 mmol/L. Three clinicians (3/35 (8.5%)) reported having experienced problems with frequent hypoglycaemia during ongoing insulin treatment.ConclusionsThis study demonstrates extensive differences in clinical practice regarding neonatal hyperglycaemia both within and between neonatal units in Sweden. Randomised controlled trials are needed to provide evidence for clinical guidelines and to improve and standardise the care of these infants.
Combination of Metabolomics and Bioinformatics to Reveal the Mechanism of Luteolin in the Treatment of Cervical Cancer
Authors: Cao Dong‐min , Rao Yin , Liu Tao , Yuan Wei‐qu 
Published: January 2025

ABSTRACTThe incidence of cervical cancer is high among women globally. The potential therapeutic efficacy of luteolin in the treatment of cervical cancer has been identified. Therefore, we aim to elucidate the mechanism of action of luteolin in the treatment of cervical cancer through a comprehensive approach that integrates metabolomics with bioinformatics. The first step involved the identification of differential metabolites through UHPLC‐Q‐Orbitrap‐MS, which were then utilized for enrichment analysis of metabolic pathways and to determine the targets associated with these differential metabolites. Subsequently, the differential analysis and WGCNA were employed to identify DEGs and functional module genes respectively. The common targets were obtained by intersecting the results from the aforementioned three analyses, followed by conducting GO and KEGG pathway enrichment analysis on these targets. Subsequently, PPI networks were constructed using these common targets, and key targets were identified utilizing the MCC, EPC, Degree, Closeness Centrality, Betweenness Centrality, and Bottleneck algorithms in the CytoHubba plug‐in. The subsequent steps involved the analysis of key genes for constructing a nomogram, conducting a ROC curve, examining content expression and survival analysis, and ultimately employing molecular docking to investigate the interaction between luteolin and crucial targets. The metabolomics analysis revealed the identification of a total of 45 distinct metabolites in this study, primarily associated with amino acid and nucleotide metabolism. The intersection of 773 differential metabolite targets, 3493 cervical cancer differential genes, and 3245 WGCNA‐associated module genes yielded a set of 32 target genes associated with luteolin therapy for cervical cancer. The GO and KEGG pathway enrichment analysis also revealed that these targets were primarily associated with amino acid metabolism and nucleotide metabolism. The CytoHubba plug‐in was utilized to identify three key genes (DMNT1, EZH2, and GMPS) through the application of multiple algorithms. Additionally, the datasets GSE63514, GSE67522, and GEPIA2 revealed a significant upregulation of all three genes in tumor tissue. ROC analysis demonstrated the good predictive ability of these three hub genes. Finally, the molecular docking results demonstrated the high binding affinity of luteolin towards DMNT1, EZH2, and GMPS. In conclusion, this study has unveiled the potential of luteolin in modulating amino acid and nucleotide metabolism for the treatment of cervical cancer, thereby providing a theoretical foundation for further investigation into the intricate association between luteolin and cervical cancer.
Toe Polydactyly and Supernumerary Nipple: Broadening the Phenotypic Spectrum of STAR Syndrome
Authors: Zgheib Omar , Jacques Léa , Frizon Louise , Windisch Gabriela , Fokstuen Siv 
Published: January 2025

ABSTRACTSTAR syndrome is a very rare X‐linked dominant disorder characterized by the association of toe syndactyly, facial dysmorphism including telecanthus and a broad nasal tip, and anogenital and renal malformations. We hereby report a patient with a novel frameshift mutation in CCNQ, the STAR syndrome causative gene. More importantly, the patient presented hitherto unreported clinical features, namely toe polydactyly in addition to syndactyly, and a supernumerary nipple. This nineteenth reported case further broadens the phenotypic spectrum of STAR syndrome.
Cross‐Sectional Matrix Exponential Spatial Models: A Comprehensive Review and Some New Results
Authors: Yang Ye , Doğan Osman , Taşpınar Suleyman , Jin Fei 
Published: January 2025

AbstractIn this paper, we provide a comprehensive review of the literature on estimation, inference, and model selection approaches for cross‐sectional matrix exponential spatial models. We first discuss the properties of the matrix exponential specification in modeling cross‐sectional dependence in comparison to the spatial autoregressive specification. We then provide a survey of the existing estimation and inference methods for cross‐sectional matrix exponential spatial models. We carefully discuss summary measures for the marginal effects of regressors, detail the matrix–vector product method for efficient computation of matrix exponential terms, and then explore model selection approaches. Our aim is not only to summarize the main findings from the spatial econometric literature but also to make them more accessible to applied researchers. Additionally, we contribute to the literature by presenting several new results. We propose an M‐estimation approach for models with heteroskedastic error terms and demonstrate that the resulting M‐estimator is consistent and asymptotically normally distributed. Moreover, we provide additional results for model selection exercises. Finally, in a Monte Carlo study, we evaluate the finite sample properties of various estimators from the literature alongside the M‐estimator.
An investigation of applicant impression management profiles over time
Authors: Schmidt Joseph A. , Bourdage Joshua S. , Lukacik Eden‐Raye , Dunlop Patrick D. 
Published: January 2025

AbstractResearch on applicant impression management (IM) has primarily been conducted in the context of interviews and personality assessments. A gap remains in understanding how applicants manage impressions on self‐report skill and biodata assessments, which are sometimes incorporated in the early stages of ‘skill‐based’ hiring processes. Moreover, there is limited research about IM behaviour over time. We present an exploratory study that identifies profiles of responses to self‐report skill inventories over time in a sample of 743 real‐world job applicants. The results identify four different longitudinal response profiles throughout the job search, indicating that individual differences influence how (or if) applicants manage impressions over time. Implications for theory and practice are discussed, including how employers can identify applicant IM by examining response patterns over time.
Effect of Biomechanical Properties of Perioral Soft Tissues on Lip Response to Simulated Protraction of Upper Front Teeth
Authors: Nguyen Khac T. , Farella Mauro , Bennani Vincent , Mei Li 
Published: January 2025

ABSTRACTBackgroundProclination of front teeth in orthodontics and oral rehabilitation may influence lip protrusion and the overall facial profile. We hypothesized that the degree of profile changes is determined by the biomechanical properties of the lips.Objectives(1) to investigate the upper lip changes induced by a simulated protraction of upper front teeth; and (2) to assess the relationship between biomechanical properties of the lips and their response to tooth protraction.Materials and MethodsThirty‐four participants were recruited at the Faculty of Dentistry, University of Otago, New Zealand. Simulated protraction of upper front teeth was achieved by placing a customised stent covering the buccal surface of the maxillary upper incisors and canines, along with the corresponding buccal mucosa and gingiva. Stereophotogrammetry was used to assess lip changes in three dimensions. Biomechanical properties of the lips, including muscle tone, stiffness and elasticity, were measured using a non‐invasive digital palpation device.ResultsDuring the simulated protraction of upper front teeth, the upper lip advanced approximately 50% of the stent thickness, with a considerable inter‐individual variation in lip displacement. Soft tissue responses were correlated with the biomechanical properties of the lips with significant correlation coefficients ranging from 0.38 to 0.40. Higher lip tone was associated with increased lip displacement, while greater lip elasticity resulted in reduced lip displacement. Multivariate analyses indicated that upper lip displacement was associated with biomechanical properties and ethnicity, but not with age, sex and body mass index.ConclusionsThe response of the lips to protraction of front teeth varies largely between individuals and can be partly explained by variations in the biomechanical properties of perioral muscles.
Place as a Metaphysical Problem in Albert the Great and Thomas Aquinas
Authors: Kamel Onsi Aaron 
Published: January 2025

AbstractThomas Aquinas’ particular synthesis of Aristotelianism and Neoplatonism, and the intellectual tradition it inaugurated, has at least twice faced critical challenges from developments in physics. Besieged by the sixteenth and seventeenth century novatores and more or less ignored by the nineteenth‐ and twentieth‐century practitioners of mathematical physics, Thomism was nevertheless forced, in both cases, to reckon with the relationship of metaphysics to physics and the related question of the nature of scientific theories. This essay begins with two opposed twentieth‐century Thomist responses to these challenges, that of Pierre Duhem and that of the River Forest Thomist school. Then, after carefully examining the concept of place in Albertus Magnus’ untranslated De Natura Loci and commentary on the Liber de Causis, putting this element of Albert's natural philosophy into conversation with Thomas Aquinas’, and investigating Thomas’ account of the ordering of the sciences, I argue that both approaches, opposites though they are, fail. Neither adequately accounts for a crucial and much‐neglected feature of Albert's and Thomas’ conception of the relationship between the sciences: the dependence of metaphysics upon various deliverances of natural philosophy.
Global Research Hotspots and Trends in Advances of the Ilizarov Technique: A Bibliometric Mapping
Authors: Wang Xinxin , Lu Fei , Wang Wenxia , Zhi Xiaoyan 
Published: January 2025

ABSTRACTObjectiveAn updated bibliometric analysis is needed to address the lack of comprehensive understanding of Ilizarov technique's research trends and hotspots, fostering collaboration and technology adoption. CiteSpace was utilized to perform co‐citation analyzes on authors, countries, institutions, journals and cited journals, authors and cited literature, along with keywords. This approach aimed to identify leaders, collaborating institutions, and research hotspots associated with the Ilizarov technique, while also predicting future development trends.MethodsData relevant to Ilizarov technologies from 1994 to 2023 were extracted from Science Net's core collection. Excel was utilized to develop an exponential function for forecasting annual publication numbers. CiteSpace V5.5 was used to conduct co‐citation analyzes, which included authors, countries (regions), institutions, journals, citation journals, authors, citations, and keywords. Burst detection algorithms were applied to analyze countries (regions), institutions, and keywords, with keyword clustering achieved using the logarithmic likelihood ratio.ResultsA total of 2030 studies were collected, with annual publications on the Ilizarov technique fitting an exponential model Y = 3E‐37e0.0439x (R2 = 0.7979). Morasiewicz Piotr from the University of Opole in Poland emerged as the most prolific author. The leading countries included the USA and China, and notable institutions included the Egyptian Knowledge Bank and the Ilizarov National Scientific Center for Restorative Traumatology and Orthopaedic. Research outputs appeared primarily in orthopedics and surgery, with a focus on keywords such as management, the Ilizarov technique, external fixation, distraction osteogenesis, reconstruction, and the Ilizarov method.ConclusionsBased on current global trends, the number of publications in the Ilizarov field will continue to increase. Future studies will likely place more emphasis on advancing application concepts and device development.
Quantitative Trait Loci Analysis for Anthracnose Resistance in a Population Derived From Andean Varieties Bukoba and Kijivu of Common Bean (Phaseolus vulgaris L.)
Authors: Kachapulula Josephine S. , Kuwabo Kuwabo , Hamabwe Swivia M. , Nkandela Mukuni , Mukuma Chikoti , Soler‐Garzón Alvaro , Miklas Phillip N. , Kamfwa Kelvin 
Published: January 2025

ABSTRACTAnthracnose (ANT) caused by the fungus (Colletotrichum lindemuthianum) is a major disease of common bean (Phaseolus vulgaris L.). The objective of this study was to identify genomic regions and candidate genes for resistance to Races 19, 38, 51, 167, 263, 1050 and 1105 of C. lindemuthianum in a population of recombinant inbred lines (RILs) derived from Andean genotypes Bukoba and Kijivu. A total of 155 F5:7 RILs and parents were evaluated for resistance to seven ANT races using artificial inoculations. The population was genotyped with 11,292 SNPs, and quantitative trait loci (QTL) analysis was conducted. A total of six QTL for resistance to seven races were identified on chromosomes Pv01 (ANT1.1BK), Pv02 (ANT2.1BK), Pv04 (ANT4.1BK), Pv05 (ANT5.1BK), Pv10 (ANT10.1BK) and Pv11 (ANT11.1BK). The R2 values for these QTL ranged from 5.2% (ANT5.1BK) to 70.1% (ANT1.1BK) suggesting that resistance to the seven races was controlled by both major‐ and minor‐effect QTL. Of the six QTL, ANT5.1BK was novel while the remaining overlapped with previously identified loci. ANT1.1BK, which provided resistance to two races (1050 and 1105), overlapped with Co‐1 while ANT4.1BK, which provided resistance to Races 19, 51, 183 and 263 overlapped with loci Co‐3, Co‐15, Co‐16, Co‐y and Co‐z. Clusters of resistance genes with NB‐ARC domain were identified as candidate genes for QTL ANT4.1BK and ANT11.1BK. Pyramiding ANT1.1BK and ANT4.1BK would provide effective resistance to Races 19, 51, 167, 263, 1050 and 1105.
Wittgenstein's method is simple: ‘Describe language‐games!’
Authors: Hardman Doug 
Published: January 2025

AbstractThere are many interpretations of what Wittgenstein's later approach entails and what its motivations are. Yet, despite extensive exegesis significantly deepening our understanding, his later approach—howsoever one interprets it—remains at best marginal and at worst ignored in contemporary philosophy. This is especially puzzling given the general consensus that Wittgenstein is a very influential philosopher. I suggest a change in approach. Rather than focussing on the potential differences to be found in Wittgenstein's work, in this essay I propose that Wittgenstein's later approach entails a core overarching method, which Wittgenstein summarises through a simple instruction: ‘Describe language‐games!’ (PI §486). I first explicate this instruction before contrasting it with the dominant method in philosophy and proposing that a recently promoted philosophical approach—Investigative Ordinary Language Philosophy—offers a practical way by which to put Wittgenstein's method into action.
Investigating the protective effect of Rosa damascena nanogel on collagenase and elastase activity and UVB‐induced dermal damage: A rodent model approach to skin photoaging
Authors: Ranjbar Negar , Osanloo Mahmoud , Nasiri‐Ghiri Mahdi , Zarenezhad Ali , Heiran Roghayeh , Ghanbariasad Ali , Namdar Najmeh , Alipanah Hiva 
Published: January 2025

AbstractWhile aging inevitably changes our skin, this complex biological process involves much more than just getting older. As the body's largest organ, the skin constantly safeguards us from harmful environmental pathogens and plays a key role in overall well‐being. This study investigated the development and evaluation of a nanogel containing Rosa damascena essential oil for its potential anti‐aging properties. The nanogel was prepared from a primary nanoemulsion with a particle size of 86 ± 4 nm. Antioxidant activity, measured using the 2,2‐diphenyl‐1‐picrylhydrazyl (DPPH) assay, was found to be 76% ± 3%. Furthermore, the nanogel demonstrated superior anti‐collagenase and anti‐elastase activities (60% ± 2% and 51% ± 0.1%, respectively) compared to the essential oil alone. The antibacterial efficacy of the nanogel was tested against Staphylococcus aureus, Escherichia coli, and Pseudomonas aeruginosa, revealing potent inhibitory effects. To simulate the aging process, rats were subjected to UVB irradiation on both legs 4 days a week before or after treatment. In vivo studies conducted on mice showed that the nanogel effectively reduced the formation of deep wrinkles in treated groups compared to pretreated ones. These findings suggest that the introduced nanogel, with its antioxidant and antimicrobial properties, holds promise as a natural therapeutic approach for wrinkle treatment.
The Lending Implications of Banks Holding Excess Capital
Authors: Pillay Neryvia , Makrelov Konstantin 
Published: January 2025

ABSTRACTBanks hold capital above microprudential and macroprudential regulatory requirements for a variety of reasons, including as a risk mitigation measure. In this study, we assess how decisions around the size of excess capital as well as monetary and financial stability actions impact sectoral lending in South Africa. Using a unique set of micro data for the South African banking sector for the period 2008 to 2020, provided by South Africa's Prudential Authority, our analysis controls for bank characteristics such as bank size, profitability and liquidity. Our results suggest that banks' decisions around holding additional capital affect their lending. As expected, monetary policy actions have a strong impact on bank lending and so do regulatory changes to bank capital requirements. These impacts tend to be smaller for larger banks, in line with results published in the global literature. Our results highlight the difficulties of thinking about policy in a Tinbergen rule type of world. Fiscal, microprudential, macroprudential and monetary policy actions can affect price and financial stability goals through their impact on credit extension. When policies work at cross purposes, they can easily undermine each other's goals.