bluuebunny/crossref_metadata_2025_split huggingface dataset:
ETV5 Silencing Produces Mesenchymal to Epithelial Transition in INS-1
(832/13) Cell Line
Authors: Díaz-López Yael Efrén , Cázares-Domínguez Vicenta , Arenas-Huertero Francisco , Gutierrez-Aguilar Ruth 
Published: February 2024

AbstractETV5 has been described to be involved in the epithelial to mesenchymal
transition (EMT) mainly in cancer. It is known that EMT provokes cytoskeleton
remodeling, improving cellular migratory, and invasive capabilities. Moreover,
overexpression of ETV5 has been correlated to cancer development and this
gene has been implicated in cell proliferation. However, little is known about
the downregulation of ETV5 expression in a pancreatic cell line and the
inverse mesenchymal to epithelial transition (MET). Therefore, we studied the
implications of ETV5 silencing over the phenotype of the insulinoma INS-1
(832/13) cell line and described the MET by partial ETV5
silencing in the INS-1 (832/13) cell line. The downregulation of
ETV5 expression was obtained by using ETV5 siRNA in the
insulinoma rat cell line, INS-1 (832/13). Then, ETV5 knockdown
provoked a MET phenotype observed by crystal violet staining and verified by
immunohistochemistry against E-cadherin. Wound healing assay showed no
migration, and F-actin stain revealed rearrangement of actin microfilaments. In
addition, TGFβ1 and TGFβ3 were downregulated in
the absence of ETV5. ETV5 silencing induces epithelial phenotype
by downregulating TGFβ1 and TGFβ3 in INS-1
(832/13) cell line.
Association between Acute and Chronic Inflammatory States: A Case-Control Study
Authors: Mahesh Seema , Mallappa Mahesh , Vacaras Vitalie , Shah Viraj , Serzhantova Elena , Kubasheva Nadezhda , Chabanov Dmitriy , Tsintzas Dionysios , Jaggi Latika , Jaggi Atul , Vithoulkas George 
Published: February 2024

Abstract
Background Fever is the hallmark of efficient acute inflammatory response, which may be disrupted in chronic inflammatory conditions. The “continuum theory” proposes that the return of acute inflammatory states with high fever predicts improvement in chronic diseases during treatment. Our objective was to investigate the observation made, during classical homeopathic treatment, that such an association exists between chronic inflammation and efficient acute inflammation.
Methods In a case-control study, the reports of patients diagnosed with chronic inflammatory conditions with at least 6 months of follow-up under homeopathic treatment were retrospectively sampled from homeopathic medical practices from Greece, India, Romania and Russia. Twenty patients who improved under homeopathic treatment and 20 age-matched controls of those who did not improve were selected. The occurrence of common acute infectious diseases with fever during the follow-up period was investigated.
Results The average age of the cases and controls was 28.4 (SD: 16.64) and 27.9 (SD: 17.19) years respectively. 18/20 cases and 4/20 controls developed common infectious diseases with fever. Cramer's V co-efficient value was found to be 0.551 (p < 0.01), indicating that improvement was more in patients with fever than without. Odds ratio of improving with respect to development of acute infectious diseases was 36.0 (95% CI: 5.8 to 223.5). The binary logistic regression model indicated significant contribution of occurrence of acute infections with fever as a predictor for improvement in chronic inflammatory disease.
Conclusions Classical homeopathic clinical observations indicate an association between chronic inflammatory status in the body and the ability to mount efficient acute inflammation. In this case-control study, the occurrence of common infections with fever during treatment heralded improvement in chronic inflammatory disease. Further powered studies are necessary to substantiate this finding.
Posttraumatic Isolated Diffuse SAH Because of Atlas (C1) Fracture Involving Transverse Process without Vertebral Artery Injury: A Case Report
Authors: Patil Akshay , Iratwar Sandip , Jha Ashish 
Published: February 2024

AbstractTraumatic subarachnoid hemorrhage (SAH) can be seen in mild, moderate, and severe head injury. Traumatic SAH is usually present in the sulci or superficial subarachnoid space (SAS) of the cortex rather than in the basal SAS. Basal SAH is usually harmful because of the injury to vascular structure resulting into vasospasm and ischemia. Here we are presenting a rare case in which patient is presented with traumatic injury to the neck followed by the isolated diffuse SAH mostly basal without injury to the brain parenchyma. Patient was presented with the raised intracranial pressure features (headache, vomiting) and seizure. On admission, he had a Glasgow Coma Scale of E3V3M5. His computed tomography (CT) of the brain was suggestive of diffuse SAH in all cisterns especially in basal cistern. He was evaluated by angiogram that was suggestive of no major vascular involvement. His CT cervical spine was suggestive of Atlas (C1) fracture involving transverse process with medial and inward displacement of bone, probably causing vascular insult in the form of venous injury leading to the SAH.
Transjugular Intrahepatic Portosystemic Shunt Reduction for Medically Refractory Hepatic Encephalopathy
Authors: Toliver Brandon , Thornburg Matthew , Schmitz Adam , Haste Paul 
Published: February 2024

Abstract
Purpose Transjugular intrahepatic portosystemic shunt (TIPS) is an established intervention for symptomatic portal hypertension, with many patients experiencing hepatic encephalopathy (HE) as an undesirable side effect. For medically refractory HE, TIPS reduction can decrease the burden of neurotoxic metabolites. This study aimed to evaluate the efficacy of TIPS reduction for the treatment of medically refractory post-TIPS HE.
Methods A retrospective search using an institutional database yielded 45 patients who underwent TIPS reduction between 2011 and 2021. Four patients were excluded due to lack of post-TIPS HE, and 41 patients in total were included. The primary endpoint was improvement of HE after TIPS reduction as measured by the West Haven scores. Secondary endpoints included postreduction recurrence of ascites or gastrointestinal bleeding, procedural complications, and 30-day mortality.
Results TIPS reduction was performed in all 41 patients with a 30-day mortality rate of 9.8%. No deaths were attributable to the procedure itself. Twenty-seven patients (65.9%) had improvement in HE and 10 patients (24.4%) proceeded to TIPS occlusion due to refractory HE. The average pre- and postreduction West Haven grades were 2.9 ± 0.5 and 1.9 ± 1.2 (p < 0.001), respectively. One patient (2.4%) had spontaneous TIPS thrombosis after reduction and developed arterial gastrointestinal bleeding, 15 patients (36.6%) experienced recurrent ascites, and there were no cases of variceal hemorrhage.
Conclusion In this population, TIPS reduction improved medically refractory HE in 65.9% of patients with a 36.6% risk of recurrent ascites, no cases of variceal hemorrhage, and 9.8% 30-day mortality.
Overview of Nasal Airway and Nasal Breathing Evaluation
Authors: Xavier Rui 
Published: February 2024

AbstractSeveral methods are available for evaluating nasal breathing and nasal airflow, as this evaluation may be made from several different perspectives.Physiologic methods for nasal airway evaluation directly measure nasal airflow or nasal airway resistance, while anatomical methods measure nasal airway dimensions. Subjective methods evaluate nasal breathing through several validated patient-reported scales assessing nasal breathing. Computational fluid dynamics evaluates nasal airflow through the analysis of several physics' variables of the nasal airway.Being familiar to these methods is of utmost importance for the nasal surgeon to be able to understand data provided by the different methods and to be able to choose the combination of evaluation methods that will provide the information most relevant to each clinical situation.
Body Dysmorphic Disorder: A Decade of Mandatory Psychiatric Evaluation in Cosmetic Rhinoplasty Aspirants
Authors: Shandilya Munish , Bourke Stephanie , Shandilya Avi 
Published: February 2024

AbstractThe aim of rhinoplasty is to make the patient happier with their nose. The patient's perception plays a substantial role in their outcome satisfaction. Body dysmorphic disorder (BDD) is an obsessive-compulsive disorder concerning body image, which negatively distorts the patient's perception, rendering them dissatisfied with the outcome even if the results are close to the defined objectives. In this paper, we present a protocol with a two-specialist approach (rhinoplasty surgeon and a psychiatrist) to standardize BDD diagnosis using the DSM-5 criteria. The patients deemed suitable for cosmetic rhinoplasty by the rhinoplasty surgeon's first consultation were sent for Mandatory Psychiatric Evaluation (MPE) for further consultation and second opinion. MPE was employed with a semi-structured clinical interview by a psychiatrist incorporating the Cosmetic Procedure Screening Questionnaire and Appearance Anxiety Inventory. From 2010 to 2023, 1,602 patients attended our practice seeking cosmetic rhinoplasty, out of which, 892 were sent for MPE to the same psychiatrist. The MPE identified 2.5% (22/892) patients as having mild BDD; out of which, 15 were considered suitable for surgical intervention and underwent successful rhinoplasty (follow up: 1–10 years, M = 4.33 years). Although BDD is considered a contraindication in rhinoplasty, our experience shows that borderline and mild BDD can be offered surgery with good insight and support system. Moderate to severe BDD in our practice was filtered out at the first stage and was not offered surgical intervention. BDD among rhinoplasty aspirants is not as prevalent as previously reported. Standardized diagnostic protocols and studying the severity of BDD when present has clarified management of BDD in rhinoplasty aspirants in our practice. MPE is not easy to incorporate in every rhinoplasty practice, but we aim to present guidelines arising from our ongoing experience to help management of BDD in rhinoplasty.
Concomitant Surgical Ablation for Treatment of Atrial Fibrillation in Patients Undergoing Minimally Invasive Mitral Valve Surgery: A Single-Center Experience in Vietnam
Authors: Chuong Pham Tran Viet , Thuan Phan Quang , Thanh Vu Tri , Dinh Nguyen Hoang 
Published: February 2024

Abstract
Background This study presents the early and midterm outcomes of combining atrial fibrillation (AF) treatment with minimally invasive mitral valve surgery (MIMVS) at our center.
Methods From January 2017 to June 2022, our center treated a total of 86 patients with both MIMVS and surgical AF ablation. The patient cohort included 62 women (72.1%) and 24 men (27.9%). The average EuroScore II was 2.64 ± 1.49%, and the patients were followed up for an average period of 46.31 ± 9.84 months.
Results Postoperatively, 95.3% of patients experienced a change in sinus rhythm, and 86.2% were discharged in sinus rhythm. The hospital's mortality rate was 2.3%, with a late mortality rate of 3.5%. Survival analysis revealed an atrial fibrillation–free 5-year follow-up rate of 59.1 ± 9.1%. The 5-year survival rate was 92.7 ± 3.3%.
Conclusion Our 5-year experience demonstrates that the combination of MIMVS and surgical AF ablation can be routinely performed with favorable peri- and postoperative outcomes. This reflects our hospital's culture and guidance on patient selection, particularly when adopting minimally invasive approaches for multiple procedures.
Outcomes of Free Flap Transfer in Facial Reanimation: A Review
Authors: Shamil Eamon , Tan Denise Jia Yun , Grobbelaar Adriaan 
Published: February 2024

AbstractFree functional muscle transfer is is an option for reanimating the face in chronic facial nerve paralysis. The optimal outcome in these patients is the ability to restore a spontaneous smile in response to emotion. We discuss the role of free functional muscle transfer in facial paralysis treatment, the choices of nerve used in reconstruction surgery, and the application of different types of muscle flaps in facial reanimation. In this paper, we review the relevant and up-to-date academic literature regarding the outcomes of free functional muscle flap transfer in facial paralysis patients.
From an Input to an Output: The Discursive Uses of External Research Funding in Academic Career Assessment
Authors: Pietilä Maria 
Published: February 2024

AbstractSuccess in the competition for external grants has become an important indicator when progressing in academic careers. Drawing on interview data with academics across various career stages and academic fields at one Finnish university, the study identifies four discourses that elucidate why research grants are deemed significant in advancing an academic career. The findings indicate that it is appealing for universities to use research funding success as an assessment criterion due to its connections to authoritative discourses in higher education and research policy. For example, funding success is seen as a symbol of high academic quality and as a signal of an individual’s ability to thrive in a resource-scarce environment. However, in the context of limited resources for research and the introduction of new societally oriented funding instruments, utilizing funding success as an assessment criterion overlooks academics’ different prerequisites for gaining funding.
Maternal depression and children’s behavioral self-regulation: the role of parenting and children’s screen time
Authors: Wang Shuang , Huang Jin , Xie Hongbin , Liu Cong , Wang Xiaolong 
Published: February 2024

AbstractFamily processes such as maternal parenting and family screen exposure are significantly related to children’s gains in behavioral self-regulation, but the potential mechanism of these relations remains unknown. In this study, we investigated how maternal depression is associated with children’s behavioral self-regulation through the mediating role of maternal supportive parenting and children’s family screen time. A total sample of 657 Chinese children and their mothers was recruited. Results from structural equation models indicated that supportive parenting and screen time partially mediated the effect of maternal depression on children’s behavioral self-regulation by the sequential, after controlling for child demographic variables. Furthermore, supportive parenting played a partially mediating role in associations between maternal depression and children’s self-regulation. The findings provide insights into parenting practices for early childhood development in the Chinese family environment.
Embracing diversity under isolation and cease-fire: a poststructuralist look at administrators’ policy on multilingualism
Authors: Mavioglu Metin 
Published: February 2024

AbstractAlthough multilingualism in higher education context continues to garner increasing scholarly interest, research remains scarce on school administrators’ policies on multilingualism. To the best of our knowledge, this study constitutes one of the very few attempts to tackle this issue in higher education context and the first of its kind to pursue such endeavour in North Cyprus setting. This study seeks to investigate, through a post-structuralist perspective, the perceptions and policies of multilingualism by the director and assistant directors of an English preparatory school in a North Cyprus university which has flourished as a haven for international education. The study combines a multiplicity of data through semi-structured interviews and informal chats to provide a richer insight into the multifaceted case being investigated. The findings demonstrate that administrators regard multilingualism as a seal of internationalism and educational quality. They remain hesitant and even mostly sceptical, however, about whether translingual practice could offer any meaningful contribution to language learning processes. Although poststructuralist understanding considers truth and identity to be decentred and forever changing, and despite the scope of our study being limited to one particular institution only, our findings promise great potential for inspiring reflection and research in other universities in North Cyprus and elsewhere, which similarly aspire to international competition in higher education.
Is it useful to understand disease through Husserl’s transcendental phenomenology?
Authors: Choi Woosok 
Published: February 2024

AbstractThis article explores the relationship between disease and our understanding of it through the lens of Husserl’s phenomenology. It argues that understanding disease requires us to examine the fundamental conditions and various aspects and that phenomenology provides a way to do this. Husserl’s transcendental phenomenology helps us identify the structures of experience necessary for the possibility of experiencing disease, and to recognize how these structures shape our understanding of it. His transcendental philosophy reveals that the subjective experience of illness can be understood in terms of general concepts. In this point, this article will critically sketch some misunderstandings of disease, followed by an exploration of phenomenological explorative methods. Husserl’s phenomenological inquiry is significant in its disclosure of ways in which internal experiences can be shared as general concepts.
Learners’ beliefs about English language learning
Authors: Kang Hyun-Sook 
Published: February 2024

Abstract
This study explored the beliefs about English language learning demonstrated by Korean-speaking college students
while sojourning in the United States. Adopting a contextual approach to learner beliefs, the study further examined the nature of
changes in sojourners’ beliefs and what aspects of study abroad were related to such changes. To this end, the study drew on the
participants’ accounts of their second language (L2) experiences in connection with different aspects of study abroad through
episodic narrative interviews. A thematic analysis of the interview data suggests that sojourners’ beliefs about language learning
are reminiscent of societal ideological structures and school or familial influences. During the sojourn, learner beliefs about L2
learning were reshaped by interactions with co-nationals and members of the host community as micro-level resources situated in
the meso-level host program. Sojourners further demonstrated changes in their broad perspectives on what constitutes an in situ
form of bilingualism in the sending and host countries.
Regulating the electrical performance of contact-separation mode triboelectric nanogenerators based on double-sided groove textures
Authors: Yang Weixu , Yang Suqing , Sun Zhen , Chen Ping , Qiao Xiaoxi 
Published: February 2024

Abstract
The contact-separation mode triboelectric nanogenerators (CS-TENGs) is a kind of micro/nano electromechanical power system based on the contact electrification and electrostatic induction. With the expansion of application field of the CS-TENG, regulating the electrical performance becomes essential. In this paper, simple and effective methods for the CS-TENG output regulation based on the double-sided groove textures are proposed. To do this, groove textures on both Cu contact electrode and PDMS dielectric layer are fabricated, and influences and mechanisms of the alignment angle (the angle between the direction of groove textures on the Cu electrode and that on the PDMS dielectric layer), matching condition (textures sidewall contact and non-contact) and applied pressure on the CS-TENG output are explored through output tests, contact and electrostatic simulations. It is shown that altering the alignment angle, matching condition and applied pressure of groove texture on the Cu contact electrode and PDMS dielectric layer, could simply regulate the output of CS-TENG, where changing the alignment angle is the most effective. Under low and high applied pressures, the variations of the output voltage with alignment angle from 0˚–90˚ reach to 343.8% and 297.2%, respectively, and CS-TENG at 0˚ angle outputs the maximum voltage under both pressures, while the minimum voltages under the two pressures are exhibited from different angles. The change of contact area induced by the longitudinal deformation and transverse expansion of the groove textures is the main reason for the output regulations.
Optoelectrical properties of the ternary chalcogenide SnSb2S5 as a new absorber layer for photovoltaic application
Authors: Kraidy A F , El Radaf I M , Zeinert A , Lahmar A , Peláiz-Barranco A , Gagou Y 
Published: February 2024

Abstract
A new material, tin antimony sulfide (SnSb2S5) thin films, considering different thicknesses (200 nm, 312 nm and 431 nm), were obtained by thermal evaporation onto a glass substrate. The films were studied electrically (I–V dependence) and optically to highlight their properties as photoanodes in thin film photovoltaic devices. The I–V characteristic curves showed n-type semiconductor samples with an electrical conductivity of 10−3(ohm cm)−1 under white light excitation. The values of the absorption coefficient (α) and extinction coefficient (K) were found to be enlarged by increasing the layer thickness. The SnSb2S5 films displayed a high absorption coefficient of 105 cm−1. The studied physical characterizations of tin antimony sulfide (SnSb2S5) samples showed interesting optical and electrical properties for good absorber layers in thin film solar cell devices.
A neural-network-based model of radio-frequency hollow cathode discharge characterized using particle-in-cell/Monte Carlo collision simulation
Authors: Bera Kallol , Verma Abhishek , Ganta Sathya , Rauf Shahid 
Published: February 2024

Abstract
An understanding of the plasma dynamics of radio-frequency (RF) hollow cathode discharges (HCDs) at low to moderate pressures is important due to their wide range of applications. A HCD consists of a hollow cylindrical cavity in the RF-powered cathode separated from a grounded electrode by a dielectric. In RF HCDs, RF sheath heating can play a significant role in plasma production in addition to secondary electrons. In this study, a single hollow cathode hole is modeled using the particle-in-cell/Monte Carlo collision (PIC-MCC) technique at low pressure, where kinetic effects are important. Characterization of a single hollow cathode using PIC-MCC simulation is, however, computationally expensive. For improved computational efficiency, a neural network modeling framework has been developed using the temporal variations of applied RF voltages as input and the electrode current as output. A space-filling design for computational experiments is used, where the variables include the RF voltage at the fundamental frequency, RF voltage at the second harmonic, and their phase difference. The predictions of the electrode current using the trained neural network model compare well with the results of the PIC/MCC simulations, but at a significantly lower computational cost. The neural network model predicts the current very well inside the training domain, and reasonably well even outside the training domain considered in this study.