bluuebunny/crossref_metadata_2025_split huggingface dataset:
THIẾT LẬP VÀ ĐÁNH GIÁ QUI TRÌNH SÀNG LỌC TRƯỚC SINH KHÔNG XÂM LẤN CHO HỘI CHỨNG MẤT ĐOẠN 22Q11.2
Authors: Nguyễn Phạm Trường Vinh , Phạm Thị Thuỳ Trang , Đỗ Thị Thanh Thủy , Trương Đình Kiệt , Tăng Hùng Sang , Nguyễn Hoài Nghĩa , Nguyễn Thị Tường Vy , Giang Hoa , Phan Minh Duy , Nguyễn Vạn Thông , Võ Tá Sơn , Trần Nhật Thăng , Nguyễn Cảnh Chương , Tăng Xuân Hải , Phạm Thái Hạ , Nguyễn Thị Bích Vân , Hà Thị Minh Thi 
Published: February 2024

Đặt vấn đề: Xét nghiệm sàng lọc trước sinh không xâm lấn NIPT (Non-Invasive Prenatal Testing - NIPT) đang ngày càng được ứng dụng rộng rãi trên thế giới. Gần đây, nhiều nghiên cứu cho thấy NIPT sử dụng kỹ thuật giải trình gen tự thế hệ mới (Next-generation sequencing – NGS) có khả năng phát hiện các bất thường vi mất đoạn gây ra mất đoạn 22q11.2 (hội chứng DiGeorge) ở thai Việc cải tiến liên tục phương pháp NGS trong tầm soát bất thường di truyền trước sinh cho thai phụ sẽ làm giảm đáng kể gánh nặng bệnh tật và nâng cao chất lượng dân số Việt Nam. Trong nghiên cứu này, chúng tôi xây dựng và đánh giá độ chính xác của qui trình xét nghiệm trước sinh không xâm lấn bằng phương pháp giải trình tự độ sâu lớn để sàng lọc vi mất đoạn gây ra hội chứng DiGeorge ở thai, từ đó có thể đánh giá khả năng sàng lọc toàn diện cho thai so với NIPT truyền thống. Mục tiêu: Thiết lập và đánh giá qui trình sàng lọc trước sinh không xâm lấn mất đoạn 22q11.2 gây ra hội chứng DiGeorge cho thai thông qua việc xác định độ nhạy và độ đặc hiệu kỹ thuật của xét nghiệm. Phương pháp: Chúng tôi thu nhận 134 mẫu máu ngoại vi của các thai phụ mang thai đơn trên 9 tuần tuổi thai, gồm 17 mẫu chứa vi mất đoạn thai nhi tại 22q11.2 và 117 mẫu âm tính. DNA ngoại bào được tách chiết từ mẫu huyết tương, sau đó tiến hành tạo thư viện, và giải trình tự bằng hệ thống giải trình tự thế hệ mới Nextseq 2000. Thông tin giải trình tự được tính toán và chuyển đổi thành tín hiệu gen bình thường và tín hiệu gen vi mất đoạn. Mô hình học máy được huấn luyện trên 10 mẫu dương tính và 10 mẫu âm tính, và đánh giá trên tập dữ liệu gồm 7 mẫu dương tính và 107 mẫu âm tính. Kết quả: Mô hình phát hiện toàn bộ 7 mẫu dương tính thật và 4 mẫu dương tính giả trong tổng số 114 mẫu được dự đoán. Trong khi đó, 103/107 mẫu âm tính thật đã được phát hiện chính xác. Sử dụng thông số trên, nghiên cứu xác định độ nhạy kỹ thuật là >99%, độ đặc hiệu kỹ thuật là 96,3%, giá trị tiên đoán dương là >63,6%, và giá trị tiên đoán âm là >99%. Kết luận: Nghiên cứu đã thiết lập được qui trình sàng lọc trước sinh không xâm lấn bằng kỹ thuật giải trình tự thế hệ mới cho vi mất đoạn tại 22q11.2 ở thai nhi với độ chính xác cao. Đây là tiền đề quan trọng tiến tới khả năng mở rộng phạm vi sàng lọc của xét nghiệm trước sinh không xâm lấn nhằm phát hiện các bệnh vi mất đoạn phổ biến cho thai nhi.
O funderentismo de Susan Haack e o duplo aspecto dos julgamentos morais
Authors: Franco Monica 
Published: February 2024

O presente artigo tem como objetivo caracterizar a teoria funderentista defendida por Susan Haack para, posteriormente, refletir sobre o modo como a distinção ‘estado-conteúdo’, que é responsável conferir um duplo aspecto a essa teoria, pode auxiliar na compreensão dos julgamentos morais. A caracterização tanto da teoria funderentista quanto das críticas de Haack ao fundacionismo e ao coerentismo tem como fio condutor o seu livro Evidence and Inquire: Towards Reconstruction in Epistemology (1993). A reflexão sobre os julgamentos morais, sobretudo no âmbito da epistemologia moral, procura corroborar a hipótese de que o cognitivismo moral ampliado, que considera diferentes tipos de conhecimento moral, pode ser pensado como uma teoria de duplo aspecto. A principal vantagem dessa abordagem é que a distinção estado-conteúdo ajuda a esclarecer mais adequadamente como a motivação se conecta com os julgamentos morais e, consequentemente, com o conhecimento moral, evitando a dicotomia ‘crença’/‘não-crença’. Entre os muitos detalhes que essa explicação precisa preencher para se tornar uma teoria metaética completa, há uma objeção importante para ser respondida, que é relativa àsuposta irrelevância de conteúdo da motivação que acompanha os estados mentais que tendemos a considerar como julgamentos morais. Será argumentado que é possível vislumbrar uma resposta para essa objeção nos debates sobre razões normativas e razões motivadoras, especialmente entre Bernard Williams (1979) e Derek Parfit (1997).
Auf den Spuren von Erich von Drygalski am Großen Karajak-Gletscher in Grönland
Authors: Dietrich Reinhard , Knöfel Christoph , Scheinert Mirko , Rosenau Ralf 
Published: February 2024

Abstract. Erich von Drygalski führte in den Jahren 1891 und 1892/93 gemeinsam mit dem Biologen Ernst Vanhöffen umfangreiche Forschungsarbeiten in Westgrönland durch, wobei zur Überwinterung eine Forschungsstation am Großen Karajak-Gletscher errichtetet wurde. An gleicher Stelle erfolgten durch eine Gruppe der Technischen Universität Dresden 2007 und 2019 geodätische Feldarbeiten. Im Beitrag werden das Areal der damaligen Station sowie die geodätisch-glaziologischen Forschungsarbeiten Erich von Drygalskis vorgestellt. Ein Vergleich mit heutigen Messungen zeigt, dass sich der Große Karajak-Gletscher in 120 Jahren kaum verändert hat.
Hybrid-Lambda: a low-specific-rating rotor concept for offshore wind turbines
Authors: Ribnitzky Daniel , Berger Frederik , Petrović Vlaho , Kühn Martin 
Published: February 2024

Abstract. We introduce an aerodynamic rotor concept for an offshore wind turbine which is tailored for an increased power feed-in at low wind speeds by a substantial increase in the rotor diameter while maintaining the rated power. The main objective of the conceptual design is to limit the steady-inflow loads (blade flapwise root bending moment (RBM) and thrust) to the maximum values of a reference turbine. The outer part of the blade (i.e. outer 30 % span) is designed for a higher design tip speed ratio (TSR) and a lower axial induction than the inner part. By operating at the high TSR in light winds, the slender outer part fully contributes to the increased power capture. In stronger winds the TSR is reduced and the torque generation is shifted to the inner section of the rotor. Moreover, the blade design efficiently reduces the power losses when the flapwise RBM is limited through peak shaving, below rated wind speed. This is of high importance, given the wind speed distribution at offshore sites. The characteristics of the rotor are first investigated with stationary blade element momentum simulations and further analysed with aeroelastic simulations, considering the flexibility of blades and tower to show that a structural design is feasible even for a blade of this size and complexity. The economic revenue and the cost of valued energy of the turbine are estimated and compared to the IEA 15 MW offshore reference turbine, considering a fictitious wind-speed-dependent feed-in price. Our results for the turbine concept with an increase in rotor diameter by 36 % show that the revenue can be increased by 30 % and the cost of valued energy can be reduced by 16 % compared to the reference turbine.
Vanlighet, försäkran och riskmedvetenhet: äldreboendens självpresentationer på Instagram under covid-19-pandemin
Authors: Carlstedt Elisabeth 
Published: February 2024

Denna studie undersöker hur äldreboenden presenterade sina verksamheter på Instagram under covid-19-pandemins första år, genom kvalitativ analys av fyra intervjuer med företrädare för äldreboenden, samt 1748 bilder från två Instagramkonton.
Resultatet visar att medan boendenas företrädare i intervjuerna beskrev år 2020 som kaosartat, presenterades livet på äldreboendena på Instagram som aktivt och socialt, i likhet med presentationer från innan pandemin. Tre budskap identifierades i Instagrammaterialet: att verksamheten bedrevs som vanligt, att pandemin pågick, men att publiken inte behövde oroa sig, samt att pandemin pågick och var ett reellt hot.
Studien drar slutsatsen att budskapen på Instagram främst syftade till att lugna oroliga anhöriga under besöksförbudet, genom att utgöra motbilder mot en negativ medierapportering. Genom anpassning till publikens förväntningar kan verksamheter förmedla lugnande budskap och därmed skydda sitt anseende även i kriser. Även om presentationer på sociala medier förmedlar tillrättalagda budskap kan de för en utomstående publik betraktas som en attraktiv, aktuell och tillgänglig källa till information om vad som pågår på äldreboenden, särskilt då insynen är begränsad.

Normality, assurance, and risk awareness: Nursing homes’ self-presentations on Instagram during the Covid-19 pandemic
This study examines how nursing homes presented their daily activities on Instagram during the first year of the covid-19 pandemic, through a qualitative analysis of four interviews with representatives of these facilities and 1748 images from two Instagram accounts.
The results show that while representatives described the year 2020 as chaotic in the interviews, life in nursing homes was presented on Instagram as active and sociable, similar to presentations from before the pandemic. Three messages were identified in the Instagram material: that the daily activities were running as usual, that the pandemic was ongoing but the audience did not need to worry, and that the pandemic was ongoing and posed a real threat.
The study concludes that the messages on Instagram were primarily aimed at reassuring concerned family members during the visitation ban by providing counter-images to negative media reports. By adapting to the audience’s expectations, nursing homes can convey reassuring messages and thereby protect their reputation even in crises. Although social media presentations may convey curated messages, they can be perceived by an external audience as an attractive, current, and accessible source of information about what is happening in nursing homes, especially when transparency is limited.
Diversity Analysis of 53 Soybean Accessions Introduced from China Based on Morphological Characteristics and SSR Markers
Authors: Dyah Rosliana Purwaning , Wibisono Kunto , Terryana Rerenstradika Tizar , Nugroho Kristianto , Utari Ratna , Suparjo Suparjo , Umar  , Lestari Puji , Tasma I Made 
Published: February 2024

Indonesia still faces challenges in meeting its national soybean demand. Genetic diversity can provide new resources to improve soybean production and quality. Genetic diversity of 53 soybean accessions introduced from China, based on morphological characteristics and 17 SSR markers, was analyzed in this study. Principal component analysis (PCA) conducted on morphological characters produced a total diversity value of 64.67% and identified four main components. Based on phylogenetic analysis and principal coordinate analysis (PCoA) two accessions showed low genetic similarity of 78% (China cult-55 and Mi yang niu mao huang), which indicated that they could be selected as parents for plant breeding programs. In addition, 772 SSR alleles at an average of 45 alleles per locus were detected. The average heterozygosity was 0.83, and the average polymorphic information content (PIC) value was 0.96. All SSR markers showed a PIC value > 0.8, indicating their informativeness in analyzing genetic diversity of soybean. The phylogenetic analysis indicated a genetic similarity of 82% and the accessions were grouped into two main clusters. The phylogenetic analysis depicted that several accessions could be grouped based on the growth type and origin. The results of morphological characterization and molecular markers in the analysis of genetic diversity are beneficial for selecting parental crosses when developing new varieties.
Treatment of women's prisons in Maranhão
Authors: Do Rêgo Elson José , Sampaio Daniel Carvalho , Sampaio Vanessa Nunes de Barros Mendes , Do Nascimento Justina Alzira Soares , Andrade Rafisa de Sousa , Cruz Mirelly Stephanie dos Santos Silva , Lustosa Thalita Furtado Mascarenhas , Pereira Kátia Cilene de Oliveira 
Published: February 2024

Considering the growing relevance of the female prison scenario in Brazil, this research aims to analyze the treatment of female detainees in the country's penitentiaries, in order to assess its impact on social reintegration and the guarantee of human rights. The significant increase in the female prison population and the need to understand and improve detention conditions motivate the research, which seeks to answer: How are women treated in Brazilian prisons and how does this influence their social reintegration and respect for human rights? The research will use a bibliographic and documentary review, analyzing academic materials, relevant case law and national legal frameworks. Consultation of various databases, such as BDTD, Google Scholar and FGV's virtual library, will contribute to achieving the proposed objectives. Thus, the general objective of the research is to analyze the treatment of inmates in Brazilian women's prisons, assessing its repercussions on social reintegration and the guarantee of human rights. It concludes that social reintegration, conceived as a comprehensive process that transcends mere physical freedom, is faced with obstacles ranging from poor prison conditions to the lack of effective resocialization programs. The lack of educational and work opportunities, combined with social stigmas, intensify the challenges faced by inmates when trying to reintegrate into society. The guarantee of human rights, a fundamental and inalienable principle, is often compromised in women's prisons. The research highlighted the urgent need for public policies that ensure the dignity, integrity and basic rights of inmates, promoting conditions conducive to true resocialization.
EFFECT OF STOCKING DENSITY ON PRODUCTIVE PERFORMANCE OF JUVENILE OF THE BLACKSTRIPE CICHLID Vieja fenestrata (CICHLIFORMES: CICHLIDAE)
Authors: Sánchez Cruz Flor , Calzada Ruiz Daniel , Peña Marín Emyr Saul , Álvarez González Carlos Alfonso , Juárez Barrientos José Manuel , Vázquez Juan Pablo Alcántar , Ramírez Ochoa José Manuel 
Published: February 2024

<p class="18AbstractandKeywords"><span class="Ninguno"><strong><span lang="EN-US">Background:</span></strong></span><span class="Ninguno"><span lang="EN-US"> Native fish species are a developing alternative for sustainable aquaculture worldwide and in Mexico, the southern region is leading the efforts in freshwater species. <strong>Objective:</strong> To assess the effect of different stocking densities on the productive performance of native fish juveniles of blackstripe cichlid (<em>Vieja fenestrata</em>).<em> </em><strong>Methodology:</strong> A one-factor randomized experimental design was used, evaluating in triplicate four stocking densities, 0.5 (L), 2 (M), 4 (H) and 6 (S) juvenile L<sup>-1</sup>. The experiment lasted 30 days. Wet weight and total length were registered every 15 days and growth performance indices were obtained. <strong>Results:</strong> Growth and survival were superior (P&lt;0.05) for densities L and M. However, the M density showed a higher (P&lt;0.05) growth rate, weight gain, and condition factor. <strong>Implications:</strong> The stocking density showed an apparent effect on the growth and survival of juveniles of the blackstripe cichlid, with the M density showing the best results; however, a cost-benefit assessment is required before starting production of this tropical native species. <strong>Conclusion:</strong> Our results suggest that a territorial and/or food competition was probably responsible for the survival and growth obtained. Although more studies are required, it appears that <em>Vieja fenestrata</em> showed the typical patrons of behaviour of another most famous cichlids, as Nile tilapia, with high levels of aggression that depend on stoking density. </span></span></p>
INVESTIGACIONES MULTIDISCIPLINARIAS RELACIONADAS CON LAS EMOCIONES EN LAS CIENCIAS AGRÍCOLAS Y BIOLÓGICAS
Authors: García Vázquez José Alberto , Figueroa-Rodríguez Katia A. , Salinas Ruiz Josafhat , Velasco Velasco Joel , Sangerman Jarquín Dora María 
Published: February 2024

<p><strong>Background</strong>: Emotions can be defined as a temporary state aroused by relevant external biological stimuli, either adverse or positive that have specific effects on the organism both in the body and in the mind. Research that has focused on emotions has grown exponentially even in areas such as agronomy and biology. <strong>Objective</strong>: This research aimed to explore current research on emotions, in order to achieve a better understanding of how they have been addressed in the field of agricultural and biological sciences. <strong>Methodology</strong>: VOSviewer software was used to conduct a co-occurrence analysis on 792 articles related to emotions published in the Elsevier® Scopus® database, the countries that published the most, scientific journals, and institutions were also analyzed. <strong>Main findings:</strong> The results show that the United States is the most productive country. In the early stages, the functioning of the human brain was characterized, later, studies with a cognitive, physiological and psychological approach were carried out and in recent years, research focused on consumer behavior. <strong>Implications</strong>. This study contributes to a better understanding of emotions and their implications in different aspects, such as nutrition, health and emotional well-being; highlighting the need for a multidisciplinary approach for a better approximation to the understanding of the complexity that occurs in agroecosystems, particularly those in tropical and subtropical zones that face considerable gaps with respect to other regions. <strong>Conclusions:</strong> It is concluded that research on emotions is having an impact on the understanding of perception and intentions that society has to acquire goods and services provided from the agri-food sector.</p>
Invisibles et vivantes. Les Hautes-Vosges dans les sources écrites antérieures à la guerre de Trente Ans
Authors: Bischoff Georges 
Published: February 2024

L’identité montagnarde des Hautes-Vosges n’apparaît guère à ceux qui les traversent avant le milieu du XVIIe siècle. Au contraire, pour les autorités, elle est d’autant plus forte que la crête, déterminée par la fonte des neiges, est perçue comme une frontière topographique entre l’« Allemagne » et la Lorraine, voire la France. Mais ce partage a peu d’incidence sur les usages locaux : les habitants des vallées circulent aisément avec leurs marchandises ou leurs troupeaux, malgré la limite des langues. Le paysage vosgien est ouvert et densément peuplé. Les Vosges ne sont pas une terre de conquête.
Sechs Praxistipps zur Digitalisierung
Authors: Krings Markus 
Published: February 2024

Die Digitalisierung gilt als entscheidender Erfolgs- und Wettbewerbsfaktor und bietet Organisationen der Sozialen Arbeit ein hohes Innovationspotenzial und viele Chancen – zum Nutzen der Klient:innen, aber auch der Mitarbeiter:innen. So ermöglicht der Einsatz digitaler Technologien unter anderem die Entwicklung neuer Angebote, effizientere Arbeitsprozesse und eine verbesserte Kommunikation (vgl. Zink/Weber 2021, S. 2). Die konkrete Umsetzung stellt die Verantwortlichen jedoch oft vor erhebliche Herausforderungen: Wie gestalte ich die Digitalisierung in meiner Organisation? Wo fange ich an? Worauf muss ich achten? Die folgenden sechs Praxistipps bieten eine Hilfestellung.
PRIMARY OVARIAN INSUFFICIENCY, A CHALLENGING DIAGNOSIS. A CASE SERIES
Authors: Omar Sahil , VAYA MITAL , OMANWA KIREKI 
Published: February 2024

INTRODUCTION
Primary ovarian insufficiency is rare, affecting 1-2% of those under 40 with only 0.1% of cases below 30 years. Etiology is mainly idiopathic, however chromosomal defects, autoimmune processes, and iatrogenic causes are associated. Symptoms are those of menopause but of intermittent durations and severities; and management targets the symptoms and complication prevention.
CASE PRESENTATION
We present two 18-year-old patients of African and Indian descent with an eight and five-month history of amenorrhea respectively with otherwise unremarkable history and physical exams. Investigation showed elevated FSH levels of 45.07 and 88.73 mIU/ml done four weeks apart in the first patient and 68.69 in the second patient. All other parameters were normal.
DISCUSSION
Aetiology is mainly idiopathic. 10-12% of diagnosed patients have chromosomal abnormalities such as Turner’s syndrome, fragile X syndrome, and genetic permutations of FMR 1 gene. Autoimmune causes are mainly autoimmune adrenal diseases. Autoimmune thyroiditis, Dermatomyosistis and Diabetes Mellitus type 1 also show association. Mumps Oophritis is the main infectious cause. Laparoscopic surgical procedures that involve the ovaries or affect their blood supply, pelvic radiotherapy, and chemotherapy all comprise the iatrogenic causes. Lifestyle and environmental factors such as smoking and heavy metals exposure also contribute.
Diagnosis is by serum FSH levels of above 25 IU/l in two separate readings four weeks apart with a four-month history of amenorrhea occurring before 40 Years. Both patients were under 30 and met the criteria.
Management involves hormone replacement therapy for symptoms, prevention and treatment of osteoporosis, oocyte donation for infertility, and counseling for both the psychological impact of the disease and the numerous complications living with the disease.
CONCLUSION
Multidisciplinary care is necessary for management of this rare and challenging illness
UPTAKE AND OUTCOMES OF MILD OVARIAN STIMULATION FOR IN-VITRO FERTILIZATION IN AFRICA: A SYSTEMATIC REVIEW
Authors: Koigi Paul , Tripathi Akanksha 
Published: February 2024

Introduction: Assisted Reproductive Technology (ART) is beyond the economic reach of most of those inflicted by infertility in Africa. Uptake of low-cost in-vitro fertilization (LCIVF) may improve financial access of patients to advanced fertility care.
Methodology: Systematic review of open-access full articles published in English from January 2000 to May 2023. Articles were sourced via PubMed, Medline, Embase and Google Scholar databases on June 1st 2023. Search keywords used were “Mild stimulation” OR “Low-cost IVF” AND “Africa”.
Ethics: This project was subjected to Ethics review by the University of South Wales Ethics review Committee.
Results: 5 publications included out of 647 results. These were historical reports in contextualized narrative reviews with no statistics provided. Because of this, only qualitative synthesis was undertaken, and meta-analysis was not possible due to lack of statistics for comparison. Published results indicated significant financial restriction of access and no objective demonstration of actual uptake and outcomes of mild ovarian stimulation in Africa.
Discussion: There was no actual open-access published evidence regarding uptake of mild stimulation for low-cost IVF in Africa. If there is such material, it is not available to those that would actually need the information to inform providers’ practice or patient choices. This is the case despite growing evidence of increasing utility of LCIVF outside Africa. Uptake of LCIVF may potentially ameliorate financial restrictions of access to ART in Africa.