bluuebunny/crossref_metadata_2025_split huggingface dataset:
Safety and efficacy of telitacicept in refractory systemic lupus erythematosus patients who failed treatment with belimumab
Authors: Fan Qiuyu , Yang Huiqin , Liu Ya 
Published: December 2023

Abstract
Objective
This study aimed to determine the effect and safety of telitacicept, an antagonist of BLyS/APRIL-mediated B cell activation, in patients with systemic lupus erythematosus (SLE) who failed treatment with belimumab and in whom telitacicept was administered combined with conventional therapy. A review of published reports on telitacicept for SLE was also performed.

Methods
A retrospective review was performed of the records of patients seen in the Department of Rheumatology at the Wuhan Hospital of Chinese and Western Medicine, Wuhan, China, with refractory SLE who had failed treatment with belimumab. The terms “systemic lupus erythematosus” and “telitacicept” were used to identify patients reported in the English medical literature.

Results
Identified were 14 refractory SLE patients, 3 males (21%) and 11 females (79%). The median age was 32.9 years. The median disease duration was 8.9 years. Patients in this cohort received telitacicept for an average of 34.1 weeks (17–62 weeks) and the total SLE responder index 4 (SRI-4) response rate was 78.9% (n = 11). The mean SLE Disease Activity Index (SLEDAI) score declined from 8.6 at baseline (95% confidence interval [CI] 7.87–9.28) to 4.29 at the endpoint (95% CI 3.4–5.16). All cases (100%) had hypocomplementemia at baseline, and 7 cases (50%) reported normal C3 and C4 levels at the follow-up endpoint. At the observation endpoint, the 24‑h urinary protein value of the 13 cases with proteinuria (baseline 24‑h urinary protein > 0.5 g/d) displayed a reduction, and 3 values turned negative. Although some patients had low serum total immunoglobulin (Ig) levels, subnormal IgG levels, and absolute counts of peripheral blood lymphocytes after treatment, no serious infection was reported. One case was refractory lupus hepatitis confirmed by liver pathology, and upon change to change to telitacicept treatment, liver function returned to normal.

Conclusion
This is the first case series in SLE patients who accepted telitacicept treatment after failed treatment with belimumab. Our case series and review of the literature show that telitacicept combined with the original standard treatment may significantly improve disease activity while reducing prednisone use. No major safety issues were seen in this group of patients. Telitacicept may be a promising drug for the treatment of refractory lupus hepatitis.
Are the estimated needs for mental health care among adolescents from different socioeconomic backgrounds met equally in Sweden? A longitudinal survey-registry linkage study
Authors: Muwonge Joseph , Dalman Christina , Burström Bo , de Leon Antonio Ponce , Galanti Maria Rosaria , Jablonska Beata , Hollander Anna-Clara 
Published: December 2023

AbstractEvidence of inequality in the utilisation of mental health care (MHC) by adolescents in Nordic countries is mixed. This study aims to investigate if there are socioeconomic differences in the utilisation of MHC, while accounting for adolescents’ mental health status. We analysed a cohort of 3517 adolescents, followed from 7 to 9th grade (ages 13–16), to examine the association between parental socioeconomic position (SEP: education and disposable income), adolescents’ estimated needs, and the utilisation of MHC (defined as visits to secondary psychiatric care or receipt of psychotropic medication). Logistic and negative binomial regression models, with mental health status as moderator, were used to predict utilisation during each grade. Lower SEP predicted higher odds of utilising MHC in adolescents with no/mild symptoms (e.g., odds ratio, OR = 1.33, 95% CI 1.04–1.72, lower vs highest education), but not in those with moderate-to-severe symptoms (estimates close to one and non-significant). This pattern was largely explained by treatment of attention deficit hyperactivity disorder/autism spectrum disorders (ADHD/ASD) in boys. For girls with severe symptoms, lower SEP predicted reduced odds of utilising MHC for other mental disorders (OR = 0.48, 95% CI 0.25–0.92, lower education), and fewer outpatient visits when in contact with such care, although non-significant (incidence rate ratio, IRR = 0.51, 95% CI 0.25–1.05, lowest vs highest income). Our findings suggest a more equitable use of MHC for treating ADHD/ASD, but not other mental disorders such as depression and anxiety, particularly among girls.
Relationship between serum endothelin-1 and in-stent restenosis following vertebral artery stenting
Authors: He Fang , Zhong Changyang , Wu Chunli , Liu Yuan , Yu Shufeng 
Published: December 2023

AbstractThe study objective was to investigate the relations between serum endothelin-1 and in-stent restenosis in vertebral artery stenting. Sixty-eight patients undergoing re-examination of vertebral artery stenting in the Department of Cerebrovascular Disease, Hangzhou Third People’s Hospital, between April 2019 and October 2022, were invited to participate. According to the presence of vertebral artery stenting, patients were divided into the restenosis (n = 19) or non-restenosis (n = 49) groups. General clinical data and endothelin-1 levels were compared between the groups. Logistic regression analysis was used to explore the relations between endothelin-1 level and risk for in-stent restenosis. Receiver operating characteristic curves were drawn to test the diagnostic value of serum endothelin-1 level for in-stent restenosis. Compared with the non-restenosis group, restenosis group levels of low-density lipoprotein, triglycerides, and endothelin-1 were significantly higher (p < 0.05) Multivariate logistic regression analysis showed that endothelin-1, stent length, and low-density lipoprotein were independently associated with in-stent restenosis (odds ratio = 1.502, 95% confidence interval: 0.042 ~ 0.212, p = 0.000; odds ratio = 1.899, 95% confidence interval: 1.116 ~ 2.237, p = 0.000; odds ratio = 1.899, 95% confidence interval: 1.228 ~ 3.337, p = 0.001, respectively). Area under the curve for serum endothelin-1 in the diagnosis of vertebral artery in-stent restenosis was 0.938. The best diagnostic cut-off value was 11.94 ng/L. Sensitivity was 89.5%. Specificity was 85.7%. These cumulative data indicate that endothelin-1 level is independently associated with in-stent restenosis.
Performance evaluation of real-time orbit determination for LUTAN-01B satellite using broadcast earth orientation parameters and multi-GNSS combination
Authors: Li Min , Wang Yubin , Li Wenwen , Jiang Kecai , Zhang Yu , Lyu Haixia , Zhao Qile 
Published: December 2023

AbstractReal-time orbit determination (RTOD) for spacecraft using the space-borne GNSS technique needs earth orientation parameters (EOPs) for the required coordinate transformation between earth-fixed and inertial reference frames. GPS and BDS transmit EOPs in modernized navigation messages, which enables GNSS-equipped spacecraft to update EOPs onboard and improves the RTOD automaticity. However, the impact of broadcast EOP errors on RTOD has not yet been evaluated. With the GPS and BDS-3 observations collected from a Chinese low-earth orbit (LEO) mission, the LUTAN-01B satellite, we analyze the LEO RTOD performance with broadcast EOPs and GPS/BDS-3 combination for the first time. In RTOD, we parameterize the ephemeris signal-in-space range error (SISRE) to account for its slow-varying signature and to compensate for the EOP errors. Without estimating SISRE, the RTOD precision using broadcast EOPs is 70.1 cm with only GPS observations and 42.4 cm with only BDS-3, revealing degradations of 5.1 cm (7.8%) and 3.3 cm (8.4%) compared to those using the precise C04 EOPs, respectively. With SISRE estimated, the impact of broadcast EOP error is compensated and the RTOD precisions with broadcast EOPs show identical results to those with C04, reaching 36.3 cm with GPS and 25.8 cm with BDS-3. Combining GPS and BDS-3 further improves the RTOD precision to 23.9 cm. Furthermore, we show that the RTOD precision can be further improved by using GPS and BDS broadcast EOPs’ differences to correct ephemeris rotation errors. With this correction, the precision improvement of BDS-3 independent and GPS/BDS-3 combined RTOD increases significantly when BDS-3 broadcast EOPs suffer large errors due to long update intervals. During the experiment period, their maximum orbital improvements reach 10.2 and 7.7 cm, respectively, while the average improvements are both around 1.5 cm.
Screen time and quality of life in Austrian young adults
Authors: Steiner-Hofbauer Verena , Schrank Beate , Mittmann Gloria 
Published: December 2023

Abstract
Aim
This study aimed to investigate the screen-related habits and quality of life among a sample of young Austrian adults.

Subject and methods
A cross-sectional online questionnaire study was conducted, assessing quality of life using the World Health Organization (WHO) Quality of Life–BREF questionnaire. Participants were queried about their physical activity levels and screen-based activities, including social media engagement, computer or mobile phone gaming, and on-demand TV or series watching. Linear regression analysis was employed to explore the relationship between quality of life and screen time. Additionally, gender differences and correlations between quality of life and BMI and age were assessed.

Results
The study comprised 400 young Austrian adults aged 18 to 30. Findings revealed negative associations between quality of life and social media usage, as well as watching series. Conversely, quality of life was positively correlated with physical activity. While female participants exhibited significantly greater engagement with computer or mobile games, no gender differences were observed in physical activity levels. Notably, gaming accounted for the majority of screen time.

Conclusion
Elevated screen time was linked to decreased quality of life, while increased physical activity was associated with higher quality of life. Gaming emerged as the predominant screen-related activity. Future research should investigate strategies to integrate physical activity into gaming to potentially enhance overall quality of life. Promoting awareness among young adults regarding their screen usage across various devices and its potential adverse effects on their well-being could play a pivotal role in fostering improvements.
Distinct Spectral Profiles of Awake Resting EEG in Disorders of Consciousness: The Role of Frequency and Topography of Oscillations
Authors: Drążyk Dominika , Przewrocki Karol , Górska-Klimowska Urszula , Binder Marek 
Published: December 2023

AbstractThe prolonged disorders of consciousness (PDOC) pose a challenge for an accurate clinical diagnosis, mainly due to patients’ scarce or ambiguous behavioral responsiveness. Measurement of brain activity can support better diagnosis, independent of motor restrictions. Methods based on spectral analysis of resting-state EEG appear as a promising path, revealing specific changes within the internal brain dynamics in PDOC patients. In this study we used a robust method of resting-state EEG power spectrum parameter extraction to identify distinct spectral properties for different types of PDOC. Sixty patients and 37 healthy volunteers participated in this study. Patient group consisted of 22 unresponsive wakefulness patients, 25 minimally conscious patients and 13 patients emerging from the minimally conscious state. Ten minutes of resting EEG was acquired during wakefulness and transformed into individual power spectra. For each patient, using the spectral decomposition algorithm, we extracted maximum peak frequency within 1–14 Hz range in the centro-parietal region, and the antero-posterior (AP) gradient of the maximal frequency peak. All patients were behaviorally diagnosed using coma recovery scale-revised (CRS-R). The maximal peak frequency in the 1–14 Hz range successfully predicted both neurobehavioral capacity of patients as indicated by CRS-R total score and PDOC diagnosis. Additionally, in patients in whom only one peak within the 1–14 Hz range was observed, the AP gradient significantly contributed to the accuracy of prediction. We have identified three distinct spectral profiles of patients, likely representing separate neurophysiological modes of thalamocortical functioning. Etiology did not have significant influence on the obtained results.
Anomaly Detection in Cloud Computing using Knowledge Graph Embedding and Machine Learning Mechanisms
Authors: Mitropoulou Katerina , Kokkinos Panagiotis , Soumplis Polyzois , Varvarigos Emmanouel 
Published: December 2023

AbstractThe orchestration of cloud computing infrastructures is challenging, considering the number, heterogeneity and dynamicity of the involved resources, along with the highly distributed nature of the applications that use them for computation and storage. Evidently, the volume of relevant monitoring data can be significant, and the ability to collect, analyze, and act on this data in real time is critical for the infrastructure’s efficient use. In this study, we introduce a novel methodology that adeptly manages the diverse, dynamic, and voluminous nature of cloud resources and the applications that they support. We use knowledge graphs to represent computing and storage resources and illustrate the relationships between them and the applications that utilize them. We then train GraphSAGE to acquire vector-based representations of the infrastructures’ properties, while preserving the structural properties of the graph. These are efficiently provided as input to two unsupervised machine learning algorithms, namely CBLOF and Isolation Forest, for the detection of storage and computing overusage events, where CBLOF demonstrates better performance across all our evaluation metrics. Following the detection of such events, we have also developed appropriate re-optimization mechanisms that ensure the performance of the served applications. Evaluated in a simulated environment, our methods demonstrate a significant advancement in anomaly detection and infrastructure optimization. The results underscore the potential of this closed-loop operation in dynamically adapting to the evolving demands of cloud infrastructures. By integrating data representation and machine learning methods with proactive management strategies, this research contributes substantially to the field of cloud computing, offering a scalable, intelligent solution for modern cloud infrastructures.
Towards decolonising higher education: a case study from a UK university
Authors: Tamimi Nancy , Khalawi Hala , Jallow Mariama A. , Valencia Omar Gabriel Torres , Jumbo Emediong 
Published: December 2023

AbstractThis article presents initiatives undertaken by the Department of Global Health and Social Medicine (GHSM) at King’s College London (KCL), exploring avenues to decolonise higher education institutions (HEI). HEI must integrate anti-racism agendas, challenge the European-centric academic knowledge domination, and dismantle power asymmetries. During the academic year 2021, GHSM executed (1) a gap analysis of undergraduate modules, (2) a course on decolonising research methods taught by global scholars to 40 Global South and North university students who completed pre- and post-course surveys, and (3) semi-structured interviews with 11 academics, and a focus group with four students exploring decolonising HEI; findings were thematically analysed. (1) Gap analysis revealed a tokenistic use of Black and minority ethnic and women authors across modules’ readings. (2) The post-course survey showed that 68% strongly agreed the course enhanced their decolonisation knowledge. (3) The thematic analysis identified themes: (1) Decolonisation is about challenging colonial legacies, racism, and knowledge production norms. (2) Decolonisation is about care, inclusivity, and compensation. (3) A decolonised curriculum should embed an anti-racism agenda, reflexive pedagogies, and life experiences involving students and communities. (4) HEI are colonial, exclusionary constructs that should shift to transformative and collaborative ways of thinking and knowing. (5) To decolonise research, we must rethink the hierarchy of knowledge production and dissemination and the politics of North-South research collaborations. Decolonising HEI must be placed within a human rights framework. HEI should integrate anti-racism agendas, give prominence to indigenous and marginalised histories and ways of knowing, and create a non-hierarchical educational environment, with students leading the decolonisation process.
On-Site Calibration Procedure and Uncertainty Contributions on Air Temperature Sensors
Authors: Aranda Natali Giselle , Merlone Andrea 
Published: December 2023

AbstractDue to the increasing demand of climate change studies, traceability of measurements according to the International System of Units (SI) becomes fundamental to establish data quality and comparability in time. With the aim of guaranteeing the traceability, in October 2022, an on-site calibration of three thermometers operated by the Osservatorio meteorologico di Moncalieri was assessed. The calibration by comparison against traceable travelling standards was performed in a transportable thermal chamber manufactured by the Istituto Nazionale di Ricerca Metrologica (INRIM). Results showed that the main uncertainty contributions to the expanded uncertainty were the interpolation method, the chamber inhomogeneity and the repeatability of the sensors under calibration. This current calibration was compared with previous calibration in 2012 (on-site calibration) and in 2016 (laboratory calibration). The comparison analysis evidenced the drift effect on the thermometers and the importance of having an active calibration program to reduce this effect. Regarding the expanded uncertainty, both on-site calibrations presented the same order of magnitude and smaller than the correction values. This paper points out the advantage of performing an on-site calibration: since the calibration involves the same dataloggers and cables in the same environmental conditions, the calculated calibration curve represents more convincingly the real measurement conditions.
Examining boundaries in a large-scale educational research-practice partnership
Authors: Sjölund Simon , Lindvall Jannika 
Published: December 2023

AbstractResearch-practice partnerships (RPPs) are emerging as a promising approach for educational change by closing the gap between educational research and practice. However, these partnerships face several challenges, such as addressing cultural differences as well as relationship-building in a historically unbalanced relationship between researchers and practitioners. Scholars have argued that these cultural differences, also called boundaries, have learning potential if approached constructively, but that we need to know more about what characterizes them in an educational context. The aim of this study is to contribute to our understanding of frameworks for RPPs. By analysing 45 hours of video recordings from meetings in an RPP between four researchers and 300 practitioners, the study offers a characterization of seven different boundaries organized into three different boundary themes: a) prerequisites for collaboration, b) collaborative practices, and c) collaborative content. Moreover, the different boundaries affect the positioning of different actors in the RPP. For example, depending on the boundary expressed, teachers are positioned as either flawed implementers or co-inquirers. We argue that the boundaries and different participant positions within the RPPs they reinforce may affect their learning potentials.
On the role of selective nucleation and growth to recrystallization texture development in a Mg–Gd–Zn alloy
Authors: Mouhib F. , Gao B. , Al-Samman T. 
Published: December 2023

AbstractOne of the main material properties altered by rare earth additions in magnesium alloys is texture, which can be specifically adjusted to enhance ductility and formability. The current study aims at illuminating the texture selection process in a Mg–0.073at%Gd–0.165at%Zn alloy by investigating recrystallization nucleation and early nucleus growth during static recrystallization. An as-cast sample of the investigated alloy was deformed in uniaxial compression at 200 °C till 40% strain and was then cut into two halves for subsequent microstructure characterization via ex situ and quasi in situ EBSD investigations. In order to gain insights into the evolution of texture during recrystallization, the contributions from dynamic and static recrystallization were initially separated and the origin of the non-basal orientation of recrystallization nuclei was traced back to several potential nucleation sites within the deformed matrix. Considering the significant role of double-twin band recrystallization in determining the recrystallization texture, this type of recrystallization nucleation was further investigated via quasi-in situ EBSD on a deformed sample, annealed at 400 °C for different annealing times. With progressive annealing, a noticeable trend was observed, in which the basal nuclei gradually diminished and eventually vanished from the annealed microstructure. In contrast, the off-basal nuclei exhibited continuous growth, ultimately becoming the dominant contributors to the recrystallization texture. The study therefore emphasizes the importance of particular nucleation sites that generate favorably oriented off-basal nuclei, which over the course of recrystallization outcompete the neighboring basal-oriented nuclei in terms of growth and thereby dominate the recrystallization texture.
Dual-functional Polyvinylidene Fluoride Beta Cyclodextrin-Grafted Graphene Oxide Mixed Matrix Membranes for Removal of Anionic Azo Dyes
Authors: Ndlovu Lloyd N. , Mokubung Kopano E. , Donga Cabangani , Gumbi Nozipho N. , Mishra Ajay K. , Nxumalo Edward N. , Mishra Shivani B. 
Published: December 2023

AbstractMixed matrix PVDF polymeric membranes were incorporated with β–CD grafted graphene oxide (GO) nanocomposites (β–CD-g-GO) via nonsolvent induced phase separation method and used in the adsorption of congo red (CR) and methyl orange (MO) dyes. The incorporation of β–CD-g-GO (6 wt%) was found to improve the membrane physico-chemical properties and performance. The water content was increased by 24.26%, contact angle reduced from 84.17 to 62.97° while flux increased from 12.42 to 275.03 L m−2 h−1 bar−1. The membranes were able to remove 100% of CR at pH 7 and 99.4% of the MO dye at pH 5 within 240 min. The adsorption kinetics and isotherms were well fitted to the pseudo second-order kinetic model and Freundlich isotherm model respectively. These results indicated that the adsorption of both dyes occurred via chemisorption and in a multilayer on a heterogeneous surface of the membranes. According to these findings, it was concluded that the adsorption mechanism was due to hydrogen bonding interactions between nitrogen and hydroxyl groups, inclusion complexation introduced by β–CD molecules and electrostatic interactions, between the negatively charged oxygen-containing groups of the membrane and the positively charged nitrogen and azo-linkages of the dye molecules. PVDF/β–CD-g-GO membranes have shown excellent adsorption efficiency towards azo dyes. This work indicates that the embedding of adsorptive GO-β–CD nanocomposites in PVDF membranes can remove anionic dyes from wastewater treatment.