bluuebunny/crossref_metadata_2025_split huggingface dataset:
Patterns and factors associated with SSRI medication adherence: a retrospective study using pharmacy claims data
Authors: Hijazi Bayan M , Popovici Ioana , Nusair Mohammad B , Alvarez Goar 
Published: October 2023

Abstract

Objectives
To assess the patterns and risk factors associated with selective serotonin reuptake inhibitor (SSRI) medication adherence among enrollees of a multiple employer welfare beneficiary association operating in Florida.

Methods
This study used a pharmacy claims database for beneficiaries of the Independent Colleges and Universities Benefits Association. The sample of 2541 patients were enrollees who filled two or more consecutive SSRI prescriptions during the analysis period 2015–20. Adherence was measured as the proportion of days covered by a medication. Multiple logistic regression analysis was used to explore the relationship between sociodemographic, healthcare access, and clinical and medication-related factors and adherence.

Key findings
Adherence was associated with higher odds of being female [odds ratio (OR): 1.2, 95% confidence interval (CI): 0.995–1.464, P &lt; .10] and higher pill burden (OR: 1.3, CI: 1.021–1.642, P&lt; 0.05). Patients using only retail pharmacies (OR: 0.356, CI: 0.196–0.645, P &lt; .01), having any out-of-pocket costs (OR: 0.552, CI: 0.348–0.875, P &lt; .50), changing the prescriber over the duration of the treatment (OR: 0.708, CI: 0.589–0.851, P &lt; .01), taking antihypertensive (OR: 0.708, CI: 0.5077–0.988, P &lt; 0.50), and asthma (OR: 0.609, CI: 0.450–0.826, P &lt; .01) medications were less likely to be adherent. Prescriber specialty was not found to be associated with adherence.

Conclusion
These findings can inform policymakers and healthcare insurance companies on barriers to medication access and recommend strategies to eliminate these barriers and design interventions to improve the adherence of groups at risk for nonadherence. Healthcare providers can identify patients who are less likely to be adherent and customize counseling interventions for these patients.
Traits linked to natural variation of sulfur content in Arabidopsis thaliana
Authors: de Jager Nicholas , Shukla Varsa , Koprivova Anna , Lyčka Martin , Bilalli Lorina , You Yanrong , Zeier Jürgen , Kopriva Stanislav , Ristova Daniela 
Published: October 2023

Abstract
Sulfur (S) is an essential mineral nutrient for plant growth and development; it is important for primary and specialized plant metabolites that are crucial for biotic and abiotic interactions. Foliar S content varies up to 6-fold under a controlled environment, suggesting an adaptive value under certain natural environmental conditions. However, a major quantitative regulator of S content in Arabidopsis thaliana has not been identified yet, pointing to the existence of either additional genetic factors controlling sulfate/S content or of many minor quantitative regulators. Here, we use overlapping information of two separate ionomics studies to select groups of accessions with low, mid, and high foliar S content. We quantify series of metabolites, including anions (sulfate, phosphate, and nitrate), thiols (cysteine and glutathione), and seven glucosinolates, gene expression of 20 genes, sulfate uptake, and three biotic traits. Our results suggest that S content is tightly connected with sulfate uptake, the concentration of sulfate and phosphate anions, and glucosinolate and glutathione synthesis. Additionally, our results indicate that the growth of pathogenic bacteria is enhanced in the A. thaliana accessions containing higher S in their leaves, suggesting a complex regulation between S homeostasis, primary and secondary metabolism, and biotic pressures.
Investigation of the Efficacy of Lanthanoid Heavy Metal Acetates as Electron Staining Reagents for Biomembrane Vesicles
Authors: Ishii Noriyuki , Odahara Takayuki 
Published: October 2023

Abstract
Transmission electron microscopy (TEM) has revolutionized our understanding of protein structures by enabling atomic-resolution visualization without the need for crystallography, thanks to advancements in cryo-TEM and single particle analysis methods. However, conventional electron microscopy remains relevant for studying stained samples, as it allows the practical determination of optimal conditions through extensive experimentation. TEM also facilitates the examination of supramolecular complexes encompassing proteins, lipids, and nucleic acids. In this study, we investigated the applicability of lanthanoid reagents as electron-staining alternatives to uranyl acetate, which is globally regulated as a nuclear fuel material. We focus on a model biomembrane vesicle system, the chromatophores from the purple photosynthetic eubacterium Rhodospirillum rubrum, which integrate proteins and lipids. Through density distribution analysis of electron micrographs, we evaluated the efficacy of various lanthanoid acetates and found that triacetates of neodymium, samarium, and gadolinium exhibited similar staining effectiveness to uranyl acetate. Additionally, triacetates of praseodymium, erbium, and lutetium, followed by europium show promising results as secondary candidates. Our findings suggest that lanthanoid transition heavy metal acetates could serve as viable alternatives for electron staining in TEM, offering potential advantages over uranyl acetate.
Two-Stage Endovascular Treatment of a Traumatic Pseudoaneurysm of Superior Mesenteric Artery Branch in a Soldier After a Military Combat Mission
Authors: Przemysław Nowakowski , Uchto Wojciech , Maciąg Rafał , Stoliński Jarosław , Hrycek Eugeniusz 
Published: October 2023

ABSTRACT
Aneurysms and pseudoaneurysms of the visceral arteries are a rare pathology with a prevalence of 0.1-2% in the general population, most common in men. Despite low prevalence, visceral aneurysms pose a significant threat to the patient’s health and life; a ruptured superior mesenteric branch aneurysm carries mortality rates of 10-25% and up to 30-90%. This article presents a case of a 50-year-old former active duty soldier and veteran of a military combat mission in Afghanistan, during which he sustained a traumatic injury resulting from a mine explosion under a vehicle. After completing the mission and returning home, the patient developed abdominal pain. The diagnosis made in the general surgery department of the district hospital was upper gastrointestinal obstruction and aneurysmal rupture of the superior mesenteric branch with inflammatory infiltration of the pancreatic–intestinal area. The patient underwent emergency gastrointestinal anastomosis and Braun enteroenterostomy. The aneurysm was not resected. One month later, the patient underwent a follow-up abdominal angiotomography, which revealed an approximately 20-mm aneurysm of a branch of the superior mesenteric artery and celiac artery subocclusion (Dunbar syndrome) with extensive collateral circulation. A diagnosis of pseudoaneurysm/traumatic aneurysm was made, and the patient was referred to a vascular surgery center for endovascular treatment. Following CT angiography, a decision was made to perform a two-stage endovascular repair. The first stage was a bridge therapy aimed to release celiac artery subocclusion with a stent; after 3 weeks, pseudoaneurysm embolization was performed. The decision to use two-stage endovascular treatment was attributable to the risk of gastrointestinal ischemia that might result from intraoperative technical difficulties and complications, coil dislocation, and thrombosis of the superior mesenteric artery or its branch; the coexisting subocclusion of the celiac artery was also considered. The patient was discharged in good condition and returned to normal everyday activities. He also continued follow-up appointments with a vascular surgeon. An angiotomography performed at 1 year of endovascular treatment confirmed good effects of the embolization procedure and coagulation of the aneurysm. Visceral aneurysms are a rare vascular pathology but are associated with significant morbidity and mortality rates. The incidence of ruptured aneurysms is probably underestimated as some patients may be operated on for acute abdominal symptoms, e.g., bowel obstruction.
Orbital parameters for an ELM white dwarf with a white dwarf companion: LAMOST J033847.06+413424.2
Authors: Yuan Hailong , Li Zhenwei , Bai Zhongrui , Dong Yiqiao , Cheng Yao , Chen Xuefei , Zhang Zhixiang , Wang Mengxin , Yang Mingkuan , Huang Xin , He Yuji , Zhang Liyun , Wang Junfeng , Zhao Yongheng , Chu Yaoquan , Zhang Haotong 
Published: October 2023

ABSTRACT
Double white dwarf systems are of great astrophysical importance in the field of gravitational wave and Type Ia supernova. While the binary fraction of CO core white dwarf is about a few per cents, the extremely low mass white dwarfs are all thought to be within binary systems. In this work, we report the orbital solution of a double degenerate system: J033847.06+413424.24, an extremely low mass He core white dwarf orbiting a CO core white dwarf. With LAMOST and P200, time domain spectroscopic observations have been made and spectral atmosphere parameters are estimated to be Teff ∼ 22 500 K and log g ∼ 5.6 dex. Combining Gaia parallax, 3D extinction, and evolution tracks, we estimate a radius of ∼0.12 R⊙ and a mass of ∼0.22 M⊙. With the 37 single exposure spectra, the radial velocities are measured and the orbital parameters are estimated to be P = 0.1253132(1) d, K1 = 289 ± 4 km s−1 and Vsys = −41 ± 3 km s−1. The radial velocity based system ephemeris is also provided. The light curves from several photometric surveys show no orbital modulation. The orbital solution suggests that the invisible companion has a minimum mass of about 0.60 M⊙ and is ∼0.79 M⊙ for an inclination of 60.0°, indicating most probably a CO core white dwarf. The system is expected to merge in about 1 Gyr. With present period and distance (∼596 pc) it cannot irradiate strong enough gravitational wave for LISA. More double degenerate systems are expected to be discovered and parametrized as the LAMOST survey goes on.
The star formation histories of quiescent ultra-diffuse galaxies and their dependence on environment and globular cluster richness
Authors: Ferré-Mateu Anna , Gannon Jonah S , Forbes Duncan A , Buzzo Maria Luisa , Romanowsky Aaron J , Brodie Jean P 
Published: October 2023

ABSTRACT
We derive the stellar population parameters of 11 quiescent ultra-diffuse galaxies (UDGs) from Keck/KCWI data. We supplement these with 14 literature UDGs, creating the largest spectroscopic sample of UDGs to date (25). We find a strong relationship between their α-enhancement and their star formation histories: UDGs that formed on very short time-scales have elevated [Mg/Fe] abundance ratios, whereas those forming over extended periods present lower values. Those forming earlier and faster are overall found in high-density environments, being mostly early infalls into the cluster. No other strong trends are found with infall times. We analyse the stellar mass–metallicity, age–metallicity, and [Mg/Fe]–metallicity relations of the UDGs, comparing them to other types of low mass galaxies. Overall, UDGs scatter around the established stellar mass–metallicity relations of classical dwarfs. We find that GC-rich UDGs have intermediate-to-old ages, but previously reported trends of galaxy metallicity and GC richness are not reproduced with this spectroscopic sample due to the existence of GC-rich UDGs with elevated metallicities. In addition, we also find that a small fraction of UDGs could be ‘failed-galaxies’, supported by their GC richness, high alpha-abundance, fast formation time-scales and that they follow the mass–metallicity relation of z ∼2 galaxies. Finally, we also compare our observations to simulated UDGs. We caution that there is not a single simulation that can produce the diverse UDG properties simultaneously, in particular the low metallicity failed galaxy like UDGs.
Shedding far-ultraviolet light on the donor star and evolutionary state of the neutron-star LMXB Swift J1858.6−0814
Authors: Castro Segura N , Knigge C , Matthews J H , Vincentelli F M , Charles P , Long K S , Altamirano D , Buckley D A H , Modiano D , Torres M A P , Buisson D J K , Fijma S , Alabarta K , Degenaar N , Georganti M , Baglio M C 
Published: October 2023

ABSTRACT
The evolution of accreting X-ray binary systems is closely coupled to the properties of their donor stars. Consequently, we can constrain the evolutionary track a system is by establishing the nature of its donor. Here, we present far-ultraviolet (far-UV) spectroscopy of the transient neutron-star low-mass X-ray binary J1858 in different accretion states (low-hard, high-hard, and soft). All of these spectra exhibit anomalous N v, C iv, Si iv, and He ii lines, suggesting that its donor star has undergone CNO processing. We also determine the donor’s effective temperature, Td ≃ 5700 K, and radius, Rd ≃ 1.7 R⊙, based on photometric observations obtained during quiescence. Lastly, we leverage the transient nature of the system to set an upper limit of $\dot{M}_{\rm acc} \lesssim 10^{-8.5}~{\rm M}_{\odot }~\mathrm{ yr}^{-1}$ on the present-day mass-transfer rate. Combining these with the orbital period of the system, Porb = 21.3 h, we search for viable evolution paths. The initial donor masses in the allowed solutions span the range 1 M⊙ ≲ Md,i ≲ 3.5 M⊙. All but the lowest masses in this range are consistent with the strong CNO-processing signature in the UV line ratios. The present-day donor mass in the permitted tracks are 0.5 M⊙ ≲ Md,obs ≲ 1.3 M⊙, higher than suggested by eclipse modelling. Since Porb is close to the so-called bifurcation period, both converging and diverging binary tracks are permitted. If the former is confirmed, J1858 will end its life as an ultracompact system with a substellar donor.
Magnetic fields in multiphase turbulence: impact on dynamics and structure
Authors: Das Hitesh Kishore , Gronke Max 
Published: October 2023

ABSTRACT
Both multiphase gas and magnetic fields are ubiquitous in astrophysics. However, the influence of magnetic fields on mixing of the different phases is still largely unexplored. In this study, we use both turbulent radiative mixing layer (TRML) and turbulent box simulations to examine the effects of magnetic fields on cold gas growth rates, survival, and the morphology of the multiphase gas. Our findings indicate that, in general, magnetic fields suppress mixing in TRMLs, while turbulent box simulations show comparatively marginal differences in growth rates and survival of the cold gas. We reconcile these two seemingly contrasting results by demonstrating that similar turbulent properties result in comparable mixing, regardless of the presence or absence of magnetic fields. We, furthermore, find the cold gas clump size distribution to be independent of the magnetic fields, but the clumps are more filamentary in the MHD case. Synthetic Mg ii absorption lines support this picture being marginally different with and without magnetic fields; both cases align well with observations. We also examine the magnetic field strength and structure in turbulent boxes. We generally observe a higher mean magnetic field in the cold gas phase due to flux freezing and reveal fractal-like magnetic field lines in a turbulent environment.
The spin of a stellar black hole 4U 1543−47 determined by Insight-HXMT
Authors: Chen Jiashi , Wang Wei 
Published: October 2023

ABSTRACT
We present a spectral analysis of Insight-HXMT observations of the low-mass X-ray binary 4U 1543−47 which locates in our Milky Way galaxy during the 2021 outburst. We focus on the observations in its soft state, and attempt to determine the spin of the black hole candidate through thermal continuum-fitting (CF) method. The spin derived from CF method is highly dependent on black hole mass, distance and inclination angle of inner disc. In this article, we have adopted the preferred range of parameters: M = 9.4 ± 1 M⊙, D = 7.5 ± 0.5 kpc, and $\mathrm{ \mathit{ i}}=36.3^{+5.3}_{-3.4}$ degrees. We attain a moderate spin, a = 0.46 ± 0.12, which is consistent with previous results measured in the 2002 outburst. Besides, we notice the spectra show a wide blue-shifted absorption feature between 8–10 keV which would originate from the highly ionized iron line. We try to fit the feature with xstar model and suggest that this feature may come from relativistic disc wind with a velocity of vwind ∼ 0.2 c. We attribute this relativistic disc wind to the super-Eddington accretion during the black hole outburst.
COALAS II. Extended molecular gas reservoirs are common in a distant, forming galaxy cluster
Authors: Chen Z , Dannerbauer H , Lehnert M D , Emonts B H C , Gu Q , Allison J R , Champagne J B , Hatch N , Indermüehle B , Norris R P , Pérez-Martínez J M , Röttgering H J A , Serra P , Seymour N , Shimakawa R , Thomson A P , Casey C M , De Breuck C , Drouart G , Kodama T , Koyama Y , Lagos C D P , Macgregor P , Miley G , Rodríguez-Espinosa J M , Sánchez-Portal M , Ziegler B 
Published: October 2023

ABSTRACT
This paper presents the results of 475h of interferometric observations with the Australia Telescope Compact Array towards the Spiderweb protocluster at z=2.16. We search for large, extended molecular gas reservoirs among 46 previously detected CO(1−0) emitters, employing a customised method we developed. Based on the CO emission images and position–velocity diagrams, as well as the ranking of sources using a binary weighting of six different criteria, we have identified 14 robust and 7 tentative candidates that exhibit large extended molecular gas reservoirs. These extended reservoirs are defined as having sizes greater than 40 kpc or supergalactic scale. This result suggests a high frequency of extended gas reservoirs, comprising at least 30 percent of our CO-selected sample. An environmental study of the candidates is carried out based on Nth nearest neighbour and we find that the large molecular gas reservoirs tend to exist in denser regions. The spatial distribution of our candidates is mainly centred on the core region of the Spiderweb protocluster. The performance and adaptability of our method are discussed. We found 13 (potentially) extended gas reservoirs located in eight galaxy (proto)clusters from the literature. We noticed that large extended molecular gas reservoirs surrounding (normal) star-forming galaxies in protoclusters are rare. This may be attributable to the lack of observations low-J CO transitions and the lack of quantitative analyses of molecular gas morphologies. The large gas reservoirs in the Spiderweb protocluster are potential sources of the intracluster medium seen in low redshift Virgo- or Coma-like galaxy clusters.
What’s in a binary black hole’s mass parameter?
Authors: Tiwari Vaibhav 
Published: October 2023

ABSTRACT
The black hole (BH) masses measured from gravitational wave observations appear to cluster around specific mass values. Consequently, the primary (and chirp) mass distribution of binary black holes (BBHs) inferred using these measurements shows four emerging peaks. These peaks are approximately located at a primary (chirp) mass value of 10 $\, \mathrm{M}_\odot$ (8$\, \mathrm{M}_\odot$), 20 $\, \mathrm{M}_\odot$ (14 $\, \mathrm{M}_\odot$), 35 $\, \mathrm{M}_\odot$ (28 $\, \mathrm{M}_\odot$), and 63 $\, \mathrm{M}_\odot$ (49 $\, \mathrm{M}_\odot$). Although the presence of the first and third peaks has been attributed to BBH formation in star clusters or due to the evolution of stellar binaries in isolation, the second peak has received relatively less attention because it lacks significance in the primary mass distribution. In this article, we report that confidence in the second peak depends on the mass parameter we choose to model the population on. Unlike primary mass, this peak is significant when modelled on the chirp mass. We discuss the disparity as a consequence of mass asymmetry in the observations that cluster at the second peak. Finally, we report this asymmetry as part of a potential trend in the mass ratio distribution manifested as a function of the chirp mass, but not as a function of primary mass, when we include the observation GW190814 in our modelling. The chirp mass is not a parameter of astrophysical relevance. Features present in the chirp mass, but not in the primary mass, are relatively difficult to explain and expected to garner significant interest.
ADCdb: the database of antibody–drug conjugates
Authors: Shen Liteng , Sun Xiuna , Chen Zhen , Guo Yu , Shen Zheyuan , Song Yi , Xin Wenxiu , Ding Haiying , Ma Xinyue , Xu Weiben , Zhou Wanying , Che Jinxin , Tan Lili , Chen Liangsheng , Chen Siqi , Dong Xiaowu , Fang Luo , Zhu Feng 
Published: October 2023

Abstract
Antibody-drug conjugates (ADCs) are a class of innovative biopharmaceutical drugs, which, via their antibody (mAb) component, deliver and release their potent warhead (a.k.a. payload) at the disease site, thereby simultaneously improving the efficacy of delivered therapy and reducing its off-target toxicity. To design ADCs of promising efficacy, it is crucial to have the critical data of pharma-information and biological activities for each ADC. However, no such database has been constructed yet. In this study, a database named ADCdb focusing on providing ADC information (especially its pharma-information and biological activities) from multiple perspectives was thus developed. Particularly, a total of 6572 ADCs (359 approved by FDA or in clinical trial pipeline, 501 in preclinical test, 819 with in-vivo testing data, 1868 with cell line/target testing data, 3025 without in-vivo/cell line/target testing data) together with their explicit pharma-information was collected and provided. Moreover, a total of 9171 literature-reported activities were discovered, which were identified from diverse clinical trial pipelines, model organisms, patient/cell-derived xenograft models, etc. Due to the significance of ADCs and their relevant data, this new database was expected to attract broad interests from diverse research fields of current biopharmaceutical drug discovery. The ADCdb is now publicly accessible at: https://idrblab.org/adcdb/.
PharmGWAS: a GWAS-based knowledgebase for drug repurposing
Authors: Kang Hongen , Pan Siyu , Lin Shiqi , Wang Yin-Ying , Yuan Na , Jia Peilin 
Published: October 2023

Abstract
Leveraging genetics insights to promote drug repurposing has become a promising and active strategy in pharmacology. Indeed, among the 50 drugs approved by FDA in 2021, two-thirds have genetically supported evidence. In this regard, the increasing amount of widely available genome-wide association studies (GWAS) datasets have provided substantial opportunities for drug repurposing based on genetics discoveries. Here, we developed PharmGWAS, a comprehensive knowledgebase designed to identify candidate drugs through the integration of GWAS data. PharmGWAS focuses on novel connections between diseases and small-molecule compounds derived using a reverse relationship between the genetically-regulated expression signature and the drug-induced signature. Specifically, we collected and processed 1929 GWAS datasets across a diverse spectrum of diseases and 724 485 perturbation signatures pertaining to a substantial 33609 molecular compounds. To obtain reliable and robust predictions for the reverse connections, we implemented six distinct connectivity methods. In the current version, PharmGWAS deposits a total of 740 227 genetically-informed disease-drug pairs derived from drug-perturbation signatures, presenting a valuable and comprehensive catalog. Further equipped with its user-friendly web design, PharmGWAS is expected to greatly aid the discovery of novel drugs, the exploration of drug combination therapies and the identification of drug resistance or side effects. PharmGWAS is available at https://ngdc.cncb.ac.cn/pharmgwas.