bluuebunny/crossref_metadata_2025_split huggingface dataset:
Age-Independent Transfer After Successful Associative Mnemonic Training
Authors: Sandberg Petra , Boraxbekk Carl-Johan , Zogaj Idriz , Nyberg Lars 
Published: October 2023

AbstractGeneralization of training to support the performance on new tasks—transfer—has been much studied. One hypothesis is that transfer occurs if overlapping neuronal circuits are engaged in both training and transfer tasks. Here, we investigated transfer effects in the domain of episodic memory by following 356 participants between 20 and 83 years who downloaded and used a smart phone application to practice the method of loci (MoL) over 3 months. We measured transfer of MoL training to three associative memory tasks with hypothesized neurocognitive overlap (binding in the hippocampus) with the trained task. Transfer tasks were administered at the beginning of training and when two specific proficiency levels in Loci training were reached. Results showed robust transfer effects across the age span at both levels. These results indicate that app-based strategy training can lead to enhancement of episodic memory beyond the specific training task, which may have clinical implementations.
Multivariate central limit theorems for random clique complexes
Authors: Temčinas Tadas , Nanda Vidit , Reinert Gesine 
Published: October 2023

AbstractMotivated by open problems in applied and computational algebraic topology, we establish multivariate normal approximation theorems for three random vectors which arise organically in the study of random clique complexes. These are:

the vector of critical simplex counts attained by a lexicographical Morse matching,

the vector of simplex counts in the link of a fixed simplex, and

the vector of total simplex counts.

The first of these random vectors forms a cornerstone of modern homology algorithms, while the second one provides a natural generalisation for the notion of vertex degree, and the third one may be viewed from the perspective of U-statistics. To obtain distributional approximations for these random vectors, we extend the notion of dissociated sums to a multivariate setting and prove a new central limit theorem for such sums using Stein’s method.
Directional transport of drug droplets based on structural and wettability gradients on antibacterial Janus wound plaster with hemostatic, antiextravasation, and prehealing properties
Authors: Lin Jing , Yao Zhen , Xiong Minmin , Lin Jin , Hu Fei , Wei Xinchuan , Huang Songyin 
Published: October 2023

AbstractThe failure of wound healing is majorly attributed to uncontrolled bleeding and bacterial infections. However, developing a wound plaster that can stop bleeding, resist blood extravasation, and realize directional transportation of drugs to promote wound healing remains a significant challenge. Herein, a superhydrophilic/hydrophobic polyvinyl alcohol/chitosan/silver@Thermoplastic polyurethane (PVA/CS/Ag@TPU) Janus membrane with structural and wettability gradients is developed. In this newly developed membrane, water is absorbed from blood via the superhydrophilic layer, which is attached to the wound, and the charge interactions between platelets and the introduced chitosan (CS) promote blood clotting. The capillary pressure resistance (∆p > 0) of the superhydrophilic layer toward the hydrophobic layer prevents blood permeation, thereby reducing blood loss. The favorable ∆p (< 0) of the membrane based on its structural and wettability gradients can realize the directional transportation of drugs that promote wound healing from the hydrophobic to the superhydrophilic layer. The incorporation of CS and silver endows the Janus membrane with intrinsic antibacterial properties (99.9%). The formation of the hydrated layer on the hydrophilic layer imparts a resisting effect, further endowing the membrane with antiadhesion and antibacterial properties. Experiments involving mice with full-thickness skin wounds revealed that the wound-healing rate increased from 87.65% to ~ 100% when the Janus membrane was loaded with the prehealing drug. Moreover, the dressing accelerated wound healing, regenerated epidermal and granulation tissues, promoted collagen formation, and reduced scar size. Thus, this gradient design strategy opens an avenue for the development of next-generation wound dressings.
Graphical abstract
Keep It Simple: Evaluating Local Search-Based Latent Space Editing
Authors: Meißner Andreas , Fröhlich Andreas , Geierhos Michaela 
Published: October 2023

AbstractSemantic image editing allows users to selectively change entire image attributes in a controlled manner with just a few clicks. Most approaches use a generative adversarial network (GAN) for this task to learn an appropriate latent space representation and attribute-specific transformations. Attribute entanglement has been a limiting factor for previous approaches to attribute manipulation. However, more recent approaches have made significant improvements in this regard using separate networks for attribute extraction. Iterative optimization algorithms based on backpropagation can be used to find attribute vectors with minimal entanglement, but this requires large amounts of GPU memory, can lead to training instability, and requires differentiable models. To circumvent these issues, we present a local search-based approach to latent space editing that achieves comparable performance to existing algorithms while avoiding the aforementioned drawbacks. We also introduce a new evaluation metric that is easier to interpret than previous metrics.
Digital Organizational Culture: A Qualitative Study on the Identification and Impact of the Characteristics of a Digital Culture in the Craft Sector
Authors: Kocak Seyma , Pawlowski Jan 
Published: October 2023

AbstractThe organizational culture of craft enterprises shows that the average corporate culture is currently characterized by a hierarchical organizational culture that does not do justice to increasing competition. Digital corporate culture in the craft sector is essential for maximizing Digital Transformation opportunities. A semi-structured interview was conducted with employees and managers from various craft sectors to determine the specific characteristics and possible effects of Digital Organizational Culture in the craft sector. The results show that digital skills, attitudes, communication, proactivity, entrepreneurial orientation, and personal skills are essential. It is found that many factors positively influence the Digital Organizational Culture in the craft sector. However, some factors can also have a negative influence on the culture. Guilds and chambers of skilled crafts should also help sensitize employees and managers to Digital Transformation to establish an explicit Digital Organizational Culture.
Effect of a novel controlled thermomechanical treatment on the microstructure and mechanical properties of a high-carbon nanobainitic steel
Authors: Janus K. , Rogal L. , Dutkiewicz J. , Chulist R. , Korpala G. , Prahl U. , Konczak K. , Kochmanski P. , Nalepka K. , Maziarz W. 
Published: October 2023

Abstract
The effect of the novel controlled thermomechanical treatment, including torsion components in the elastic strain range during the isothermal holding on the microstructure and mechanical properties of the high-carbon nanobainitic steel, was investigated. TEM observations of the thermo-mechanically treated steel revealed bainitic ferrite laths with an average size of 68 ± 40 nm and films of retained austenite with an average size of 34 ± 17 nm, along with the blocky morphology of retained austenite in sub-micron scale. The XRD synchrotron diffraction allows estimating the amount of retained austenite at 43.1 ± 1.2% volume fraction with a carbon concentration of 1.17 ± 0.09 wt.%. Furthermore, the deconvolution of (200) Fe-γ reflections corresponding to two different low-carbon and high-carbon retained austenite peaks and, simultaneously, the blocky and film-like retained austenite was performed. In addition, the Nishiyama–Wassermann (N–W) crystallographic orientation relationship between bainitic ferrite and retained austenite was described as dominant using the misorientation distribution function (MDF). The crystallographic texture results indicated that the main growth of bainitic ferrite plates occurred after removing external stress during isothermal holding. The tensile tests and hardness measurements showed a high tensile strength achieved mainly by nano-metric bainitic ferrite plates and a high dislocation density. The high level of elongation is most likely attained due to a high amount of retained austenite in steel and both TRIP and TWIP effects during tensile deformation.
Advancing green finance: a review of sustainable development
Authors: Fu Chengbo , Lu Lei , Pirabi Mansoor 
Published: October 2023

AbstractThis study comprehensively reviews the relationship between green finance and sustainable development, specifically focusing on combatting climate change and achieving carbon neutrality. Utilizing a narrative review methodology, the study examines a range of scholarly articles and publications to identify key themes, findings, and future directions in green finance. The review emphasizes the crucial role of substantial investments in green and low-carbon initiatives to address climate change effectively and promote sustainable economic growth. It highlights the necessity of robust regulatory frameworks that facilitate the availability of green finance and the integration of carbon–neutral practices. Additionally, the paper explores the potential of impact investing, wherein investors accept lower financial returns in exchange for non-financial benefits in green finance. It underscores the influential role of institutional ownership in guiding companies toward enhanced environmental and social performance. Moreover, integrating environmental, social, and governance (ESG) factors in investment decisions is critical for sustainable finance. Addressing the intersection of climate change and risk management, the review highlights the implications of environmental risks on financial decision-making. Effective communication strategies can raise public awareness and support for climate policies. The study concludes by calling for collaboration, further research, and policy measures to advance green finance and foster sustainable economic growth. It recommends aligning financial incentives with sustainable outcomes, fostering transparency, and incorporating social equity in green finance initiatives to contribute towards achieving sustainable development goals and promoting a greener future.
The Atmosphere Has Become Increasingly Unstable During 1979–2020 Over the Northern Hemisphere
Authors: Chen Jiao , Dai Aiguo 
Published: October 2023

AbstractAtmospheric instability affects the formation of convective storms, but how it has changed during recent decades is unknown. Here we analyze the occurrence frequency of stable and unstable atmospheric conditions over land using homogenized radiosonde data from 1979 to 2020. We show that atmospheric stable (unstable) conditions have decreased (increased) significantly by ∼8%–32% (of time) from 1979 to 2020 over most land areas. In boreal summer, the mean positive buoyancy (i.e., convective available potential energy [CAPE]) also increases over East Asia while mean negative buoyancy (i.e., convective inhibition [CIN]) strengthens over Europe and North America from midnight‐dawn for unstable cases. The increased unstable cases and mean CAPE result from increased low‐level specific humidity and air temperature, which increase the buoyancy of a lifted parcel. The stronger CIN results from decreased near‐surface relatively humidity and decreased lapse rate in the lower troposphere. Our results suggest that the atmosphere has become increasingly unstable, which could lead to more convective storms.
Estimation of Energy Spectrum of Precipitating Magnetospheric Electrons Based on Bremsstrahlung X‐Ray Fluxes Recorded in the Atmosphere
Authors: Makhmutov V. S. , Maurchev E. A. , Bazilevskaya G. A. , Mironova I. A. 
Published: October 2023

AbstractNumerous energetic electron precipitation events were recorded since 1963 in the atmosphere at polar latitudes in the course of regular measurements of charged particle fluxes in the Earth's atmosphere being performed by the Lebedev Physical Institute. The experimental data obtained represent the only uniform database in the world on electron precipitation events recorded directly in the atmosphere well below satellite orbits. The precipitating electrons are absorbed in the upper atmosphere. However, they generate X‐rays that can penetrate deep into the atmosphere sometimes down to altitudes of 20–35 km accessible to balloon measurements. These experimental data allow studying energy, temporal and spatial characteristics of electron precipitation events. In particular, based on PLANETOCOSMICS/GEANT4 we developed a method for evaluating the energy spectra of the primary flux of precipitating electrons. This method was used for evaluation of primary spectra of precipitating electrons assuming exponential energy distribution of incident electrons. Now, for the development of the method, we present the possibility of determining the energy spectra of electrons in the power‐law form, using new software RUSCOSMICS code. This new method, based on the GEANT4 software, makes it possible to describe the transport of precipitating electrons in the atmosphere taking into account the evolution of the energy and pitch‐angle distributions of electrons and X‐ray photons.
Equations of State and Phase Boundaries of SiO2 Polymorphs Under Lower Mantle Conditions
Authors: Li Guoge , Zhang Zhiming , Niu Xiaoguang , Liu Jin , Li Juan , Wang Wei , Zhang Zhigang 
Published: October 2023

AbstractSiO2 is an important modally abundant component of terrestrial planets, while there are few studies that quantitatively determine the properties of silica under simultaneously high‐temperature and high‐pressure conditions. In this study, thermal properties of stishovite, CaCl2‐type SiO2 and seifertite have been obtained by using extensive first‐principles simulations. The quasi‐harmonic approximation and intrinsic anharmonic effects were considered, and a generalized rescaling method was adopted to eliminate systematic errors in the simulation results. Based on the simulation data, we have established new equations of state for the SiO2 polymorphs and determined their phase boundaries. Anharmonicity has been demonstrated to show noticeable effects on their thermal properties and phase boundaries. With the new results, we found that SiO2 polymorphs show increasing buoyancy in the subducted basaltic slabs at depths greater than ∼800–900 km. In the normal lower mantle, they are readily stable over a broad range of depths approximately from 1,500 km to 2,600 km. This implies that SiO2 polymorphs may contribute to the lateral heterogeneity in the deep lower mantle as observed by small‐scale seismic scatterers.
Sirtuin4 alleviates severe acute pancreatitis by regulating HIF-1α/HO-1 mediated ferroptosis
Authors: Liu Yanna , Cui Huning , Mei Chaopeng , Cui Mengwei , He Qianqian , Wang Qiaofang , Li Dejian , Song Yaodong , Li Jiye , Chen Sanyang , Zhu Changju 
Published: October 2023

AbstractAcute pancreatitis (AP) is a common emergency of the digestive system and serious cases can develop into severe acute pancreatitis (SAP), which ortality rates up to 30%. Sirtuin4 (SIRT4) is a member of the sirtuin family, and plays a key role in inflammation and oxidative stress. However, the potential role of SIRT4 in SAP has yet to be elucidated. In the present study, we found that the expression level of SIRT4 in human AP was downregulated by screening a public database, suggesting that SIRT4 may play a role in AP. Subsequently, we used L-arginine (L-Arg) to induce SAP in SIRT4 knockout (SIRT4_KO) and SIRT4 overexpression (AAV_SIRT4) mice. The results showed that the pancreatic tissue injury and related lung and kidney injury were serious in SIRT4_KO mice after SAP induction, but were significantly reduced in AAV_SIRT4 mice. More importantly, we found that the levels of antioxidant factors GSH and SOD were decreased in SIRT4_KO mice, and the production of oxidative products and lipid peroxidation markers was increased, suggesting that SIRT4 was involved in inflammation and oxidative stress during SAP. Further studies showed that the absence or overexpression of SIRT4 affected the expression level of Hypoxia-inducible factor-1α (HIF-1α) after SAP induction, and regulated the expression of ferroptosis related proteins by mediating HIF-1α/HO-1 pathway. Collectively, our study revealed that SIRT4 plays a protective role in SAP by regulating the HIF-1α/HO-1 pathway to inhibit ferroptosis.
The involvement of caspases in the process of nuclear removal during lens fiber cell differentiation
Authors: Gheyas Rifah , Menko A. Sue 
Published: October 2023

AbstractThe terminal differentiation of lens fiber cells involves elimination of their organelles, which must occur while still maintaining their functionality throughout a lifetime. Removal of non-nuclear organelles is accomplished through induction of autophagy following the spatiotemporal suppression of the PI3K/Akt signaling axis. However, blocking this pathway is not alone sufficient to induce removal of fiber cell nuclei. While the final steps in fiber cell nuclear elimination are highlighted by the appearance of TUNEL-positive nuclei, which are associated with activation of the lens-specific DNaseIIβ, there are many steps in the process that precede the appearance of double stranded DNA breaks. We showed that this carefully regulated process, including the early changes in nuclear morphology resulting in nuclear condensation, cleavage of lamin B, and labeling by pH2AX, is reminiscent of the apoptotic process associated with caspase activation. Multiple caspases are known to be expressed and activated during lens cell differentiation. In this study, we investigated the link between two caspase downstream targets associated with apoptosis, ICAD, whose cleavage by caspase-3 leads to activation of CAD, a DNase that can create both single- and double-stranded DNA cleavages, and lamin B, a primary component of the nuclear lamina. We discovered that the specific inhibition of caspase-3 activation prevents both lamin B and DNA cleavage. Inhibiting caspase-3 did not prevent nuclear condensation or removal of the nuclear membrane. In contrast, a pan-caspase inhibitor effectively suppressed condensation of fiber cell nuclei during differentiation. These studies provide evidence that caspases play an important role in the process of removing fiber cell nuclei during lens differentiation.
The VAX2-LINC01189-hnRNPF signaling axis regulates cell invasion and migration in gastric cancer
Authors: Hong Linjie , Yang Ping , Zhang Luyu , Liu Xuehua , Wei Xiangyang , Xiao Wushuang , Yu Zhen , Zhang Jieming , Peng Ying , Wu Xiaosheng , Tang Weimei , Zhi Fachao , Li Guoxin , Li Aimin , Lin Jianjiao , Liu Side , Zhang Hui , Xiang Li , Wang Jide 
Published: October 2023

AbstractTranscription factors (TFs) and long noncoding RNAs (lncRNAs) contribute to gastric cancer (GC). However, the roles of TFs and lncRNAs in the invasion and metastasis of GC remain largely unknown. Here, we observed that the transcription factor VAX2 is significantly upregulated in GC cells and tissues and acts as an oncogene. Moreover, high VAX2 expression is associated with the advancement of tumors in GC. In terms of functionality, the enforced expression of VAX2 promotes the proliferation and metastasis of GC cells. Mechanistically, VAX2 specifically interacts with the LINC01189 promoter and represses LINC01189 transcription. Furthermore, LINC01189 exhibits significant downregulation in GC and functions as a suppressor gene. Functionally, it inhibits migratory and invasive abilities in GC cells. In the context of GC metastasis, VAX2 plays a role in modulating it by trans-repressing the expression of LINC01189. Additionally, LINC01189 binds to hnRNPF to enhance hnRNPF degradation through ubiquitination. The cooperation between LINC01189 and hnRNPF regulates GC cell invasion and migration. In addition, both VAX2 and hnRNPF are highly expressed, while LINC01189 is expressed in at low levels in GC tissues compared to normal gastric tissues. Our study suggests that VAX2 expression facilitates, while LINC01189 expression suppresses, metastasis and that the VAX2-LINC01189-hnRNPF axis plays a contributory role in GC development.
Microphysiological model reveals the promise of memory-like natural killer cell immunotherapy for HIV± cancer
Authors: Ayuso Jose M. , Farooqui Mehtab , Virumbrales-Muñoz María , Denecke Katheryn , Rehman Shujah , Schmitz Rebecca , Guerrero Jorge F. , Sanchez-de-Diego Cristina , Campo Sara Abizanda , Maly Elizabeth M. , Forsberg Matthew H. , Kerr Sheena C. , Striker Robert , Sherer Nathan M. , Harari Paul M. , Capitini Christian M. , Skala Melissa C. , Beebe David J. 
Published: October 2023

AbstractNumerous studies are exploring the use of cell adoptive therapies to treat hematological malignancies as well as solid tumors. However, there are numerous factors that dampen the immune response, including viruses like human immunodeficiency virus. In this study, we leverage human-derived microphysiological models to reverse-engineer the HIV-immune system interaction and evaluate the potential of memory-like natural killer cells for HIV+ head and neck cancer, one of the most common tumors in patients living with human immunodeficiency virus. Here, we evaluate multiple aspects of the memory-like natural killer cell response in human-derived bioengineered environments, including immune cell extravasation, tumor penetration, tumor killing, T cell dependence, virus suppression, and compatibility with retroviral medication. Overall, these results suggest that memory-like natural killer cells are capable of operating without T cell assistance and could simultaneously destroy head and neck cancer cells as well as reduce viral latency.
Synergistic investigation of natural and synthetic C1-trophic microorganisms to foster a circular carbon economy
Authors: Orsi Enrico , Nikel Pablo Ivan , Nielsen Lars Keld , Donati Stefano 
Published: October 2023

AbstractA true circular carbon economy must upgrade waste greenhouse gases. C1-based biomanufacturing is an attractive solution, in which one carbon (C1) molecules (e.g. CO2, formate, methanol, etc.) are converted by microbial cell factories into value-added goods (i.e. food, feed, and chemicals). To render C1-based biomanufacturing cost-competitive, we must adapt microbial metabolism to perform chemical conversions at high rates and yields. To this end, the biotechnology community has undertaken two (seemingly opposing) paths: optimizing natural C1-trophic microorganisms versus engineering synthetic C1-assimilation de novo in model microorganisms. Here, we pose how these approaches can instead create synergies for strengthening the competitiveness of C1-based biomanufacturing as a whole.