bluuebunny/crossref_metadata_2025_split huggingface dataset:
Comparative analysis of sensory features, microbial diversity, and their correlations in light‐flavor Daqu from different regions
Authors: Xiang Fanshu , Cai Wenchao , Guo Zhuang , Shan Chunhui 
Published: February 2024

AbstractThis study performed a comparative analysis of the sensory and microbial profiles of light‐flavor Bijou (LFD) from Taiyuan (Shanxi Province) and Suizhou (Hubei Province) in China. The results of the electronic nose showed that the aromatic substances of the LFD from Taiyuan (TLFD) were significantly higher (p < .05), while alcohol and aldehyde substances were significantly lower (p < .05) compared with the LFD from Suizhou (SLFD). The average response values of sensors W1C (sensitive to aromatic hydrocarbons), W3C (sensitive to amine and aromatic components), W5C (sensitive to olefins, aromatics, and polar molecules), and W2S (sensitive to alcohol and aldehyde compounds) to TLFD were 0.26, 0.33, 0.34, and 7.72, whereas the response values to SLFD were 0.25, 0.32, 0.33, and 8.04, respectively. The electronic tongue results showed that the aftertaste A (bitter aftertaste) and aftertaste B (astringent aftertaste) of the TLFD were significantly higher (p < .05) and umami was significantly lower (p < .05) as compared to the SLFD. The relative intensities of the aftertaste A, aftertaste B, and umami indicators of TLFD were 0.10, −0.008, and −0.22, respectively, while those of SLFD were −0.23, −0.36, and 0.835, respectively. MiSeq high‐throughput sequencing results showed that TLFD exhibited lower fungal richness and diversity compared to SLFD. The dominant bacterial genera were mainly Bacillus (58.12%), Kroppenstedtia (10.11%), and Weissella (6.26%), and the dominant fungal genera were Saccharomycopsis (67.53%), Rasamsonia (9.90%), and Thermoascus (7.10%). Streptomyces and Staphylococcus were identified as the key characteristic microorganisms in TLFD, while Kroppenstedtia, Rasamsonia, and Thermoascus were the key characteristic microorganisms in SLFD. Correlation analysis indicated a stronger correlation between microorganisms and sensory characteristics in SLFD samples. This study provides valuable insights into the sensory and microbiological characteristics of LFD from different regions and offers a new perspective for understanding the production of differently flavored light‐flavor Baijiu.
Protective effects of carvacrol on lipid profiles, oxidative stress, hypertension, and cardiac dysfunction – A comprehensive review
Authors: Khazdair Mohammad Reza , Moshtagh Mozhgan , Anaeigoudari Akbar , Jafari Shima , Kazemi Toba 
Published: February 2024

AbstractCardiovascular diseases (CVDs) are a class of illnesses that affect the heart or blood vessels, leading to the most common causes of death worldwide. In 2017, CVD caused approximately 17.8 million deaths that were increased approximately to 20.5 million deaths in 2021, globally. Also, nearly 80% of worldwide CVD deaths occur in some countries. Some herbs and their constituents due to their several pharmacological activities have been used for medicinal purposes. Carvacrol is a phenolic mono‐terpenoid found in the oils of aromatic herbs with several biological properties. The possible therapeutic effects of carvacrol on lipid profiles, oxidative stress, hypertension, and cardiac dysfunction were summarized in the current study. The data from this review article were obtained by searching the terms including; “Carvacrol”, “Hypertension”, Hypotensive, “Cardiac dysfunction”, “Ischemia”, “Lipid profile”, and Oxidative stress in several web databases such as Web of Sciences, PubMed Central, and Google Scholar, until November 2023. The results of the reviewed studies revealed that carvacrol inhibits acetylcholinesterase (AchE) activity and alters lipid profiles, reducing heart rate as well as systolic and diastolic blood pressure (BP). Carvacrol also decreased the proinflammatory cytokine (IL‐1β), while increasing secretion of anti‐inflammatory cytokine (IL‐10). Moreover, carvacrol improved oxidative stress and mitigated the number of apoptotic cells. The pharmacological effects of carvacrol on CVD might be through its antioxidative, anti‐inflammatory, and antiapoptotic effects. The mentioned therapeutic effects of carvacrol on lipid profile, hypertension, and cardiac dysfunction indicate the possible remedy effect of carvacrol for the treatment of CVD.
The time‐varying volatility spillover effects between China's coal and metal market
Authors: Lin Boqiang , Lan Tianxu 
Published: February 2024

AbstractThis study employs a time‐varying parameter vector autoregression methodology with the Diebold and Yilmaz spillover index to scrutinize the temporal fluctuations in volatility spillovers between the Chinese coal and metal markets. The analysis is conducted from the dual perspectives of security indices and futures prices. The findings reveal a robust correlation between the coal and metal markets, with the coal market serving as a primary conduit for volatility spillover into the metal market. Furthermore, this study investigates the time‐specific impacts of coal decommissioning policies, the COVID‐19 pandemic, and the coal supply crisis on the coal–metal market volatility spillovers. The findings indicate that these three unique shocks significantly increase the overall risk spillover index between the coal and metal markets. Moreover, during these exceptional events, the extent or role of risk spillover in the coal–metal market undergoes varying degrees of change. On the basis of these findings, this article presents pertinent policy recommendations.
Linking archaeology and paleoenvironment: Mid‐Holocene occupational sequences in the Varamin Plain (Iran)
Authors: Busch Robert , Bernbeck Reinhard , Hessari Morteza , Kirsten Fabian , Lüthgens Christopher , Pollock Susan , Rol Nolwen , Schütt Brigitta 
Published: February 2024

AbstractEarly human habitation of the arid to semiarid Central Iranian Plateau was strongly connected to the availability of water and associated natural hazards, such as flooding and drought events. In this geoarchaeological study, we focus on the occupation at the prehistoric site of Ajor Pazi within the formerly active fluvial environment of the Varamin Plain. Through radiocarbon and luminescence‐dated sediment cross‐sections, we apply multivariate statistics to sedimentological characteristics of bulk samples collected during a rescue excavation in 2018. Based on facies interpretations, we differentiate depositional processes and present their implications for the environs of Ajor Pazi. Our results show evidence of settlement activities between 6.4 and 5.6 ka cal B.P. (4.4–3.6 ka cal. B.C.E.). Phases of reduced geomorphodynamics can be distinguished when soil‐forming processes take place. Our findings provide insights into the hitherto scarcely explored Transitional Chalcolithic II period during which the site of Ajor Pazi emerged and began to shape its environs.
The impact of social hierarchies on neural response to feedback evaluations after advice giving
Authors: Li Jin , Li Mei , Sun Yu , Zhang Guanfei , Fan Wei , Zhong Yiping 
Published: February 2024

AbstractAdvisors generally evaluate advisee‐relevant feedback after advice giving. The response to these feedback—(1) whether the advice is accepted and (2) whether the advice is optimal—usually involves prestige. Prior literature has found that prestige is the basis by which individuals attain a superior status in the social hierarchy. However, whether advisors are motivated to attain a superior status when engaging in advice giving remains uncharacterized. Using event‐related potentials, this study investigates how advisors evaluate feedback after giving advice to superior (vs. inferior) status advisees. A social hierarchy was first established based on two advisees (one was ranked as superior status and another as inferior status) as well as participants' performance in a dot‐estimation task in which all participants were ranked as medium status. Participants then engaged in a game in which they were assigned roles as advisors to a superior or inferior status advisee. Afterward, the participants received feedback in two phases. In Phase 1, participants were told whether the advisees accepted the advice provided. In Phase 2, the participants were informed whether the advice they provided was correct. In these two phases, when the advisee was of superior status, participants exhibited stronger feedback‐related negativity and P300 difference in response to (1) whether their advice was accepted, and (2) whether their advice was correct. Moreover, the P300 was notably larger when the participants' correct advice led to a gain for a superior‐status advisee. In the context of advice giving, advisors are particularly motivated to attain a superior status when the feedback involving social hierarchies, which is reflected in higher sensitivity to feedback associated with superior status advisees at earlier and later stages during feedback evaluations in brains.
Water‐rock interactions drive chemostasis
Authors: Warix Sara , Navarre‐Sitchler Alexis , Singha Kamini 
Published: February 2024

AbstractThe western U.S. is experiencing shifts in recharge due to climate change, and it is currently unclear how hydrologic shifts will impact geochemical weathering and stream concentration–discharge (C–Q) patterns. Hydrologists often use C–Q analyses to assess feedbacks between stream discharge and geochemistry, given abundant stream discharge and chemistry data. Chemostasis is commonly observed, indicating that geochemical controls, rather than changes in discharge, are shaping stream C–Q patterns. However, few C–Q studies investigate how geochemical reactions evolve along groundwater flowpaths before groundwater contributes to streamflow, resulting in potential omission of important C–Q controls such as coupled mineral dissolution and clay precipitation and subsequent cation exchange. Here, we use field observations—including groundwater age, stream discharge, and stream and groundwater chemistry—to analyse C–Q relations in the Manitou Experimental Forest in the Colorado Front Range, USA, a site where chemostasis is observed. We combine field data with laboratory analyses of whole rock and clay x‐ray diffraction and soil cation‐extraction experiments to investigate the role that clays play in influencing stream chemistry. We use Geochemist's Workbench to identify geochemical reactions driving stream chemistry and subsequently suggest how climate change will impact stream C–Q trends. We show that as groundwater age increases, C–Q slope and stream solute response are not impacted. Instead, primary mineral dissolution and subsequent clay precipitation drive strong chemostasis for silica and aluminium and enable cation exchange that buffers calcium and magnesium concentrations, leading to weak chemostatic behaviour for divalent cations. The influence of clays on stream C–Q highlights the importance of delineating geochemical controls along flowpaths, as upgradient mineral dissolution and clay precipitation enable downgradient cation exchange. Our results suggest that geochemical reactions will not be impacted by future decreasing flows, and thus where chemostasis currently exists, it will continue to persist despite changes in recharge.
Modelling regional effects of artificial groundwater recharge in a multilayer aquifer characterized by perched water tables
Authors: Gómez‐Escalonilla Víctor , Heredia Javier , Martínez‐Santos Pedro , López‐Gutiérrez Julio , De la Hera‐Portillo África 
Published: February 2024

AbstractThis paper presents an approach to estimate the effects of a managed recharge experiment in a multilayer aquifer characterized by the presence of perched water tables in the Medina del Campo groundwater body, Douro basin, central Spain. A numerical model was developed to evaluate the effect of artificial recharge on the shallow sector of a regional‐scale aquifer and on formerly active wetlands. The model was developed in the Visual MODFLOW Pro v.2011.1 environment in order to represent and analyse the regional impact of this artificial recharge event. Results suggest that the assumption of a single perched system may prove useful in regional contexts where data is limited. From a study site perspective, managed recharge is observed to increase shallow storage along the riverbanks, which is considered valuable for environmental purposes. However, downstream wetlands are unlikely to experience a significant recovery. Furthermore, only a small percentage of artificial recharge is expected to reach the deep regional aquifer. This method can be exported to settings characterized by the presence of perched aquifers and associated groundwater dependent ecosystems.
Analysis and partitioning of terrestrial water storage in the Yellow River source region
Authors: Li Xia , Zhou Zuhao , Liu Jiajia , Xu Chongyu , Xia Junqiang , Wang Pengxiang , Wang Hao , Jia Yangwen 
Published: February 2024

AbstractIn order to increase the capability to understand and quantify the spatial differences in terrestrial water storage (TWS), and to reflect the unique energy balance processes and soil freeze–thaw mechanisms in the Qinghai‐Tibet Plateau (QTP), this study improved the energy balance processes of the water and energy transfer processes model, including its surface radiation calculations and snowmelt module. By integrating these improvements, a water and energy transfer processes model in Qinghai‐Tibet Plateau (WEP‐QTP) for the Yellow River source region (YRSR) is developed. Using the improved WEP‐QTP model to perform simulations, we assessed the daily changes in snow cover, soil moisture (SM), permafrost (PM), and groundwater storage (GWS) in the YRSR. Our analysis revealed an increase in TWS of 0.24 mm/yr from 1961 to 2020. Snow water equivalent (SWE), SM, PM, and GWS have proportional contributions of 8.33%, 216.67%, −154.17%, and 29.17% to the increased TWS, respectively. SM is the primary component of TWS. Temperature (T), precipitation (P), evapotranspiration (E), and solar radiation (Rs) influence the spatiotemporal variations in TWS, as well as those of its components. The increase in P is the primary cause for the rise in TWS, SWE, and SM, while the increase in T predominantly contributes to the decrease in PM. Furthermore, permafrost degradation and climate‐induced warming and humidification lead to increased infiltration, resulting in elevated GWS.
Associations among family socioeconomic status, parenting and sustained attention for socioeconomically disadvantaged children at age 5 years
Authors: Meng Wanqiu , Black Caroline F. D. , Feng Min 
Published: February 2024

AbstractChildren whose families experience socioeconomic disadvantage are at risk for poor sustained attention, a foundational skill related to goal‐oriented behaviour, self‐regulation and kindergarten readiness. Maternal parenting behaviours and parenting stress are theorised developmental pathways linking socioeconomic status (SES) to children's sustained attention. However, research has yet to empirically test for these indirect pathways, thus limiting the relevance of extant findings to inform targets of parent‐mediated programmes addressing attentional disparities at school entry for low‐income children. Using a sample of mostly low‐income children from the Future of Families and Child Wellbeing Study (N = 2214) and the process of parenting model, this study tested whether maternal parenting stress, harsh parenting and cognitive stimulation uniquely explained associations between SES and child sustained attention at age 5 years. Results from structural equation modelling revealed that SES was positively and directly associated with child sustained attention. Some of these effects were indirectly transmitted through the pathway of maternal cognitive stimulation; however, neither harsh parenting nor parenting stress helped to explain the relationship between SES and child sustained attention. Implications of the findings are explored in the context of early childhood prevention and promotion programmes serving low‐income families.Highlights
This study explores the direct and indirect paths of family SES on child sustained attention through the pathways of maternal cognitive stimulation, harsh parenting and parenting stress amongst socioeconomically disadvantaged children.
Results from SEM revealed that SES was positively and directly associated with child‐sustained attention and some of these effects were indirectly transmitted through the pathway of maternal cognitive stimulation.
Cognitive stimulation is a crucial pathway through which SES may promote or impede the development of children's sustained attention skills.
An ultrathin and crack‐free metal‐organic framework film for effective polysulfide inhibition in lithium–sulfur batteries
Authors: Zhou Cheng , Dong Chenxu , Wang Weixiao , Tian Yu , Shen Chunli , Yan Kaijian , Mai Liqiang , Xu Xu 
Published: February 2024

AbstractDue to their extensive microporous structure, metal‐organic frameworks (MOFs) find widespread application in constructing modification layers, functioning as ion sieves. However, the modification layers prepared by existing methods feature gaps between MOFs that are noticeably larger than the inherent MOF pore dimensions. Polysulfides and lithium ions unavoidably permeate through these gaps, hindering the full exploitation of the structural advantages. Herein, an ultrathin (20 nm) and crack‐free MOF film is formed on the separator by atomic layer deposition for the first time. Based on the separator, the mechanism of different MOF layers has been verified by phase field simulation and in situ Raman spectroscopy. The results accurately prove that the MOF particle layer can relieve the shuttle of polysulfides, but it does not have the effect of homogenizing lithium ions. Only the ultrathin and crack‐free MOF film with proper pore size can act as the ion sieve for both polysulfides and lithium ions. As a result, under the test condition of 2 mA cm−2–2 mAh cm−2, the overpotential of the Li/Li symmetric battery is only 18 mV after 2500 h. The capacity retention rate of the lithium–sulfur battery is 95.6% after 500 cycles and 80% after 1000 cycles at 2 C.
A principled examination of US bankruptcy law and the accounting for value in conversions between chapters 7 and 13
Authors: Ritter Gavin 
Published: February 2024

AbstractThis article focuses on the apportionment and distribution of post‐filing pre‐conversion increases in equity of assets in a debtor’s estate when a debtor converts from a Chapter 13 to a Chapter 7 bankruptcy proceeding. Through an examination of the history of the US Bankruptcy Code and adequate examination of differing approaches, this article argues that courts should adopt the position that the post‐filing increase in equity due to appreciation should inure to the estate rather than to the debtor, while the increases in equity through payback plans should inure to the debtor. This approach creates the fairest situation for a debtor, placing them in a situation where they receive the full benefits of the Chapter 13 bankruptcy proposition and provides sufficient economic benefits to creditors.
A phase II study of guadecitabine combined with irinotecan vs regorafenib or TAS‐102 in irinotecan‐refractory metastatic colorectal cancer patients
Authors: Lee Valerie , Parkinson Rose , Zahurak Marianna , Cope Leslie , Cercek Andrea , Verheul Henk , Gootjes Elske , Lenz Heinz Josef , Iqbal Syma , Jones Peter , Baylin Stephen , Rami Vandna , Ahuja Nita , El Khoueiry Anthony , Azad Nilofer S. 
Published: February 2024

AbstractDNA methyltransferase inhibitors (DNMTi) have demonstrated benefit in reversing resistance to systemic therapies for several cancer types. In a phase II trial of guadecitabine and irinotecan compared to regorafenib or TAS‐102 in pts with advanced mCRC refractory to irinotecan. Patients with mCRC refractory to irinotecan were randomized 2:1 to guadecitabine and irinotecan (Arm A) vs standard of care regorafenib or TAS‐102 (Arm B) on a 28‐day cycle. Between January 15, 2016 and October 24, 2018, 104 pts were randomized at four international sites, with 96 pts undergoing treatment, 62 in Arm A and 34 in Arm B. Median overall survival was 7.15 months for Arm A and 7.66 months for Arm B (HR 0.93, 95% CI: 0.58–1.47, P = .75). The Kaplan–Meier rates of progression free survival at 4 months were 32% in Arm A and 26% in Arm B. Common ≥Grade 3 treatment related adverse events in Arm A were neutropenia (42%), anemia (18%), diarrhea (11%), compared to Arm B pts with neutropenia (12%), anemia (12%). Guadecitabine and irinotecan had similar OS compared to standard of care TAS‐102 or regorafenib, with evidence of target modulation. Clinical trial information: NCT01896856.
Age‐related phenotypes in breast cancer: A population‐based study
Authors: Svanøe Amalie A. , Humlevik Rasmus O. C. , Knutsvik Gøril , Sæle Anna K. M. , Askeland Cecilie , Ingebriktsen Lise M. , Hugaas Ulrikke , Kvamme Amalie B. , Tegnander Amalie F. , Krüger Kristi , Davidsen Benedicte , Hoivik Erling A. , Aas Turid , Stefansson Ingunn M. , Akslen Lars A. , Wik Elisabeth 
Published: February 2024

AbstractBreast cancer in young (<40 years) is associated with a higher frequency of aggressive tumor types and poor prognosis. It remains unclear if there is an underlying age‐related biology that contributes to the unfavorable outcome. We aim to investigate the relationship between age and breast cancer biology, with emphasis on proliferation. Clinico‐pathologic information, immunohistochemical markers and follow‐up data were obtained for all patients aged <50 (Bergen cohort‐1; n = 355, not part of a breast screening program) and compared to previously obtained information on patients aged 50 to 69 years (Bergen cohort‐2; n = 540), who participated in the Norwegian Breast Cancer Screening Program. Young breast cancer patients presented more aggressive tumor features such as hormone receptor negativity, HER2 positivity, lymph‐node metastasis, the HER2‐enriched and triple‐negative subtypes and shorter survival. Age <40 was significantly associated with higher proliferation (by Ki67). Ki67 showed weaker prognostic value in young patients. We point to aggressive phenotypes and increased tumor cell proliferation in breast cancer of the young. Hence, tumors of young breast cancer patients may present unique biological features, also when accounting for screen/interval differences, that may open for new clinical opportunities, stratifying treatment by age.