bluuebunny/crossref_metadata_2025_split huggingface dataset:
Economics is beautiful!
Authors: Block Walter E. 
Published: December 2023

AbstractEconomics is beautiful, and all undergraduates who love and revere beauty should major in this dismal science. Beauty is defined, for present purposes as cooperation, coordination, teamwork, togetherness, inclusiveness, and assists in sports. The greater the number of people participating in the “team,” the more gorgeous is the cooperation. The less central direction, whether implicit or explicit, other things equal, the greater is the loveliness of the coordination. The economy, that which economists study, beats all the competition, as, at least ideally, it encompasses the most people on the “team” (all of us!) with the least outside direction. Well, none at all, given full free enterprise with no central planning whatsoever. That, at least, would be the extreme degree of economic freedom.
Opium Price Shocks and Prescription Opioids in the USA*
Authors: Deiana Claudio , Giua Ludovica , Nisticò Roberto 
Published: December 2023

AbstractWe investigate the effect of international opium price shocks on the per capita dispensation of prescription opioids in the USA. Using quarterly county‐level data for 2002q4–2016q4, three main results emerge. First, reductions in opium prices significantly increase the quantity of opioids prescribed, and more so in counties with a larger pre‐existing market for pain relief, as captured by the incidence of mining sites. Second, the increase involves only natural and semi‐synthetic, but not fully‐synthetic, opioids, suggesting that the effect is moderated by the amount of raw material contained in the products. The impact is larger prior to 2010, when overdose deaths were more related to the use of legally prescribed opioids. Third, advertising expenses, stock prices and the profits of opioid producers increase following negative opium price shocks, suggesting an important role of supply‐side economic incentives.
Comprehensive orthodontic treatment using miniscrews and digital rehabilitation in a patient with severe recessive dystrophic epidermolysis bullosa
Authors: Véliz Méndez Sebastián , Baeza Paredes Mauricio , Olivares Antonio , Vicuña María José , Krämer Strenger Susanne M. 
Published: December 2023

AbstractIntroductionEpidermolysis bullosa (EB) is a rare genetic disorder characterized by skin fragility and blister formation. The phenotypic presentation is broad with four major types, being Recessive Dystrophic EB (RDEB) the most severe, including oral anomalies such as severe microstomia, ankyloglossia, vestibule obliteration and occlusal anomalies, turning orthodontic treatment into a challenge.AimThis case report aims to present the comprehensive treatment of a patient with severe RDEB, including periodontal surgery, orthodontic fixed braces with mini‐screws and oral rehabilitation with anterior veneers.Case ReportA 27‐year‐old female patient with severe RDEB received orthodontic treatment in the upper jaw to improve malalignment and anterior crossbite. After 13 months of treatment with fixed appliances, miniscrews were placed in the anterior segment to intrude and procline the upper incisors. Oral surgery was performed to increase the vestibule depth of the upper lip. Once edge‐to‐edge occlusion was obtained, anterior veneers were placed to improve aesthetic and stabilize occlusion, especially with the lack of posterior support.DiscussionThe multidisciplinary treatment approach, involving orthodontic treatment, periodontal surgery and oral rehabilitation, played a crucial role in achieving favorable results. This case highlights the successful use of miniscrews as a viable orthodontic approach for patients with severe RDEB.
Minimizing early catheter failure using a risk stratification model for peritoneal dialysis
Authors: Sun Lulu , Cheng Chuan , Wang Yuqin , Luo Changqing , Ye Mingzhu , Sun Jing , Zhang Chun , Yao Lijun , Jiang Huajun 
Published: December 2023

AbstractBackgroundEarly catheter failure is the main reason for peritoneal dialysis (PD) failure, which often causes patients to withdraw from PD. Reducing the early catheter failure is critical to increase the acceptance of PD. The purpose of our study was to establish a risk stratification model to minimize early catheter failure.MethodsA retrospective study with patients underwent PD catheter placement from January 2013 to March 2022 was conducted. The primary outcome event was early catheter failure. Univariate and multivariable logistic regression were performed to select potential risk predictors. A risk stratification model and a clinical procedure were established. The effectiveness of the model was evaluated by external validation.ResultsA total of 432 patients were finally enrolled in the study. The risk for early catheter failure was associated with younger age (odds ratio [OR], 0.930; 95% confidence interval [95% CI], 0.884 to 0.972; p = 0.002), lower body mass index (BMI) (OR, 0.797; 95% CI, 0.629 to 0.964; p = 0.036), and lower albumin (ALB) levels (OR, 0.881; 95% CI, 0.782 to 0.985; p = 0.036). The risk stratification model was established and performed great discrimination capability with AUC of 0.832 (cut‐off value: 0.061, sensitivity: 0.853, specificity: 0.812). The model proved to be effective in external validation; the rate of early catheter failure was dropped off from 4.1% to 0%.ConclusionsWe established an effective risk stratification model, by which patients with high risk of early catheter failure could be precisely identified. The clinical procedure based on the model was proved to be helpful to minimize early catheter failure.
First-in-human study to evaluate the safety, tolerability, and population pharmacokinetic/pharmacodynamic target attainment analysis of FL058 alone and in combination with meropenem in healthy subjects
Authors: Huang Zhiwei , Yang Xinyi , Jin Yi , Yu Jicheng , Cao Guoying , Wang Jingjing , Hu Yingying , Dai Jingyi , Wu Jufang , Wei Qiong , Tian Yan , Yu Shuyan , Zhu Xu , Mao Xiaomeng , Liu Wei , Liang Hong , Zheng Shansong , Ju Yunfei , Wang Zenghua , Zhang Jing , Wu Xiaojie 
Published: December 2023

ABSTRACT
FL058 is a novel diazabicyclooctane β-lactamase inhibitor. This first-in-human study evaluated the safety, tolerability, and population pharmacokinetic (PK)/pharmacodynamic target attainment analysis of FL058 alone and in combination with meropenem in healthy subjects. The results showed that the maximum tolerated dose of FL058 was 3,000 mg after single-dose infusion. FL058 in combination with meropenem did not cause any grade 3 or higher adverse event when the dose was escalated up to 1,000 mg/2,000 mg. FL058 exposure PK parameters showed dose proportionality. FL058 was excreted primarily in urine. No significant PK interaction was found between FL058 and meropenem. Population PK model analysis indicated that the PK profiles of FL058 and meropenem were consistent with the two-compartment model. The impact of covariates, creatinine clearance, concomitant use of meropenem, body weight, sex, and FL058 dose, on FL058 exposure was less than 10%. FL058/meropenem combination was safe and well tolerated up to a 1,000-mg/2,000-mg dose in healthy adults. The recommended minimum dose of FL058/meropenem combination was 500 mg/1,000 mg by intravenous infusion over 2 h every 8 h based on target attainment analysis. The good safety, tolerability, and satisfactory PK profiles of FL058 alone and in combination with meropenem in this first-in-human study will support further clinical development of FL058 in combination with meropenem in patients with target infections (ClinicalTrials.gov identifiers: NCT05055687, NCT05058118, and NCT05058105).
Seven genome sequences of bacterial, environmental isolates from Pony Lake, Antarctica
Authors: Foreman Christine M. , Smith Heidi J. , Dieser Markus 
Published: December 2023

ABSTRACT
Dissolved organic matter (DOM) in Antarctic inland waters is unique in that its precursor molecules are microbially derived and lack the chemical signature of higher plants. Here, we report the genomic sequences of seven environmental, bacterial isolates from Pony Lake, Antarctica, to explore the genetic potential linked to DOM processing.
Awareness and Disposal Practices of Medicines among the Community in Hawassa City, Ethiopia
Authors: Woldamicael Bekele Daniel , Dadebo Elias , Tilahun Girma , Gebremariam Zinabu 
Published: December 2023

Despite the enormous benefits medicines provide to humanity, their improper disposal frequently leads to detrimental consequences on the environment. Lack of awareness and malpractices concerning expired, leftover, or unused (ELU) medicines have become concerns worldwide. This study assessed community awareness and practices regarding the disposal of ELU medicines in Hawassa City, Ethiopia. A community-based descriptive cross-sectional survey design was used among the urban population of Hawassa City. Multistage sampling procedures were employed to select 405 household (HH) respondents, and purposive sampling techniques were used to select key experts (KEs) and key informants (KIs). A pretested questionnaire was designed for HHs, KEs, and KIs. The results of the study showed that analgesics and antibiotics, used in 52 and 27% of the HHs, respectively, were the most commonly consumed medicines in this city. The vast majority (95.5%) of the HHs did not store expired medicines but disposed of them. Only 10% of the HHs were well informed on how to dispose of ELU medicines. Most (70%) KEs and KIs revealed that there were no awareness-creation mechanisms for the safe disposal of ELU medicines. A significantly high

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percentage (76%) of the HH respondents who were well informed on how to dispose of ELU medicines had higher education, but most (95%) of them indicated that they would not be willing to be involved in “ELU-take-back” programs even if there had been such a mechanism. Field observations confirm significant amounts of medical waste improperly discarded in various areas, including the shores of Lake Hawassa near Hawassa City. The study has shown that awareness of the management of ELU medicines is critically lacking in the community of Hawassa City, posing environmental and human health risks. Moreover, the majority of households practice unsafe disposal of ELU medicines, leading to human health threats and environmental risk.
Impact of Fruit and Fruit Juice on Death and Disease Incidence: A Sex‐Specific Longitudinal Analysis of 18 603 Adults
Authors: Xu Xiaoyue , Grafenauer Sara , Barr Margo L. , Schutte Aletta E. 
Published: December 2023

Background
The health benefits of fruits are well established, but fruit juice has been more controversial. Fruit and juice are often ingested with other foods, which prompted our investigation to determine whether fruit consumed as juice may negate the beneficial effects of consuming whole fruit in people with cardiovascular disease.

Methods and Results
We retrospectively analyzed data from a population‐based study in Australia (the 45 and Up Study) linked with hospitalization and mortality data up to September 2018. Kaplan‐Meier survival estimates and Cox proportional hazards models were used to examine effects of fruit, fruit juice, and the combination of fruit and fruit juice in relation to death and disease incidence among men and women living with cardiovascular disease. A total of 7308 deaths occurred among 18 603 participants diagnosed with cardiovascular disease over a 13‐year follow‐up. After multivariable adjustment, inadequate fruit intake (hazard ratio [HR], 1.12 [95% CI, 1.01–1.24]) and high fruit juice intake (HR, 1.26 [95% CI, 1.12–1.41]) predicted all‐cause mortality in women. Also, high fruit juice intake plus either adequate fruit intake (HR, 1.18 [95% CI, 1.02–1.37]) or inadequate fruit intake (HR, 1.43 [95% CI, 1.21–1.69]) predicted mortality in women. No relationships were found in men after multivariable adjustments. Also, we found no prognostic value for fruit and fruit juice intake on disease incidence.

Conclusions
In adults with cardiovascular disease, we found that fruit juice (in combination with adequate or inadequate fruit intake) predicted mortality in women but not in men. These effects became less clear when focusing on disease incidence.
Automated classification and tracking of microscopic holographic patterns of nematodes using machine learning methods
Authors: Ribeiro Rodrigo de P. e S. , Sobieranski Antonio C. , Gonçalves Elaine C.D. , Dutra Rafael C. , von Wangenheim Aldo 
Published: December 2023

Summary
Analysing nematode behaviour helps estimate biomechanical parameters for applications like cellular biology, pharmacology and cognitive neuroscience. Portable holographic platforms offer cost-effective, high-resolution, high-frame-rate, wide-field imaging compared to conventional microscopy. Holographic methods can reconstruct original shapes using numerical diffraction, although this is computationally expensive. However, video holography remains challenging due to the fast motion and overlapping of holograms when nematodes swim in crowded environments. In this work we address this problem by focusing on automated detection and tracking of nematodes in densely populated environments, using machine learning methods. The main advantage of our approach is to present an automated computational flow to detect and analyse the behaviour of live nematodes in video directly from the raw holographic signals, without the requirement of phase-recovering methods for diffraction. For this purpose, we developed a three-step CNN-based approach consisting of: i) nematode hologram detection; ii) temporal tracking; and iii) behavioural analysis based on mobility parameters. In terms of precision, the obtained results show that using a two-stage detector, the Faster R-CNN architecture with the ResNet18 model as a backbone, presented the best Mean Average Precision (mAP) score with 86% for correct classification. For tracking, the best performing algorithm was IoU with a HOTA, resulting in 62.42% when applied on the individually tagged nematodes, which is comparable to the best current generic multi-tracking approaches available over the literature. Our obtained results show that the use of a convolutional neural network approach associated with a classic tracking algorithm is a very suitable approach for nematode detection and behavioural analysis for biological assays directly from holograms, even in densely populated environments. The proposed approach has been presented as a promising solution for automated inspection of free-living nematode individuals.
Bone-Anchored Maxillary Protraction With Bollard Modified Miniplates: An Interim Study in Patients with Cleft Palate
Authors: Yim Nicholas H. , Parham Matthew J. , Cody Ryan J. , Wirthlin John O. , Grush Andrew E. , Buchanan Edward P. 
Published: December 2023

Purpose: Patients with cleft lip and/or palate (CLP) often present with Class III malocclusions resulting from maxillary deficiency. Although orthognathic surgery can correct this, it is not performed until skeletal maturity. Bone-anchored maxillary protraction (BAMP) can be used during adolescence to stimulate maxillary growth. We report the outcomes of BAMP therapy in 10 patients with CLP. Methods: Beginning in 2019, patients born with CLP with mild, moderate, or severe Class III malocclusion started BAMP therapy. Four Bollard miniplates were surgically placed in each patient following a standard protocol under general anesthesia. Miniplates were secured using self-tapping titanium screws. Orthodontic elastics were initiated 2 weeks after surgery with an initial loading force of 100 g bilaterally and later increased to 200 g at 12 weeks postoperatively. Before (T1) and after (T2), Cone Beam CT (CBCT) radiographs were taken and reviewed by a single examiner. Results: Ten patients met the inclusion criteria. Their mean age at the time of Bollard miniplate placement was 12.2 (range, 9-14) years. Before treatment, the average cephalometric measurements for the SNA, SNB, and ANB were 73.3°, 78.0°, and −4.7°, respectively. After treatment, the average cephalometric measurements for SNA, SNB, and ANB were 74.4°, 77.7°, and −3.3°, respectively. Conclusion: We have demonstrated positive results with BAMP therapy. BAMP therapy led to corrective orthopedic maxillary protraction and induced favorable dental and skeletal outcomes, improving overall facial balance. Cleft surgeons should consider this modality after alveolar bone grafting when treating pediatric patients with Class III malocclusions.
Exogenous abscisic acid improves grain filling capacity under heat stress by enhancing antioxidative defense capability in rice
Authors: Liu Xiaolong , Zhong Xin , Liao Jingpeng , Ji Ping , Yang Jinshuo , Cao Zhiruo , Duan Ximiao , Xiong Junru , Wang Ying , Xu Chen , Yang Hongtao , Peng Bo , Jiang Kai 
Published: December 2023

Abstract
Background
Heat stress is a major restrictive factor that causes yield loss in rice. We previously reported the priming effect of abscisic acid (ABA) on rice for enhanced thermotolerance at the germination, seedling and heading stages. In the present study, we aimed to understand the priming effect and mechanism of ABA on grain filling capacity in rice under heat stress.

Results
Rice plants were pretreated with distilled water, 50 μM ABA and 10 μM fluridone by leaf spraying at 8 d or 15 d after initial heading (AIH) stage and then were subjected to heat stress conditions of 38 °C day/30 °C night for 7 days, respectively. Exogenous ABA pretreatment significantly super-activated the ABA signaling pathway and improved the SOD, POD, CAT and APX enzyme activity levels, as well as upregulated the ROS-scavenging genes; and decreased the heat stress-induced ROS content (O2– and H2O2) by 15.0–25.5% in rice grain under heat stress. ABA pretreatment also increased starch synthetase activities in rice grain under heat stress. Furthermore, ABA pretreatment significantly improved yield component indices and grain yield by 14.4–16.5% under heat stress. ABA pretreatment improved the milling quality and the quality of appearance and decreased the incidence of chalky kernels and chalkiness in rice grain and improved the rice grain cooking quality by improving starch content and gel consistence and decreasing the amylose percentage under heat stress. The application of paraquat caused overaccumulation of ROS, decreased starch synthetase activities and ultimately decreased starch content and grain yield. Exogenous antioxidants decreased ROS overaccumulation and increased starch content and grain yield under heat stress.

Conclusion
Taken together, these results suggest that exogenous ABA has a potential priming effect for enhancing rice grain filling capacity under heat stress at grain filling stage mainly by inhibiting ROS overaccumulation and improving starch synthetase activities in rice grain.
From pilot to a multi-site trial: refining the Early Detection of Deterioration in Elderly Residents (EDDIE +) intervention
Authors: Allen Michelle J. , Carter Hannah E. , Cyarto Elizabeth , Meyer Claudia , Dwyer Trudy , Oprescu Florin , Aitken Christopher , Farrington Alison , Shield Carla , Rowland Jeffrey , Lee Xing J. , Graves Nicholas , Parkinson Lynne , Harvey Gillian 
Published: December 2023

Abstract
Background
Early Detection of Deterioration in Elderly Residents (EDDIE +) is a multi-modal intervention focused on empowering nursing and personal care workers to identify and proactively manage deterioration of residents living in residential aged care (RAC) homes. Building on successful pilot trials conducted between 2014 and 2017, the intervention was refined for implementation in a stepped-wedge cluster randomised trial in 12 RAC homes from March 2021 to May 2022. We report the process used to transition from a small-scale pilot intervention to a multi-site intervention, detailing the intervention to enable future replication.

Methods
The EDDIE + intervention used the integrated Promoting Action on Research Implementation in Health Services (i-PARIHS) framework to guide the intervention development and refinement process. We conducted an environmental scan; multi-level context assessments; convened an intervention working group (IWG) to develop the program logic, conducted a sustainability assessment and deconstructed the intervention components into fixed and adaptable elements; and subsequently refined the intervention for trial.

Results
The original EDDIE pilot intervention included four components: nurse and personal care worker education; decision support tools; diagnostic equipment; and facilitation and clinical support. Deconstructing the intervention into core components and what could be flexibly tailored to context was essential for refining the intervention and informing future implementation across multiple sites. Intervention elements considered unsustainable were updated and refined to enable their scalability. Refinements included: an enhanced educational component with a greater focus on personal care workers and interactive learning; decision support tools that were based on updated evidence; equipment that aligned with recipient needs and available organisational support; and updated facilitation model with local and external facilitation.

Conclusion
By using the i-PARIHS framework in the scale-up process, the EDDIE + intervention was tailored to fit the needs of intended recipients and contexts, enabling flexibility for local adaptation. The process of transitioning from a pilot to larger scale implementation in practice is vastly underreported yet vital for better development and implementation of multi-component interventions across multiple sites. We provide an example using an implementation framework and show it can be advantageous to researchers and health practitioners from pilot stage to refinement, through to larger scale implementation.

Trial registration
The trial was prospectively registered with the Australia New Zealand Clinical Trial Registry (ACTRN12620000507987, registered 23/04/2020).
Effectiveness and safety of regimens containing linezolid for treatment of Mycobacterium abscessus pulmonary Disease
Authors: Cheng Li-ping , Zhang Qing , Lou Hai , Shen Xiao-na , Qu Qing-rong , Cao Jie , Wei Wei , Sha Wei , Sun Qin 
Published: December 2023

Abstract
Objective
To evaluate the effectiveness and safety of linezolid-containing regimens for treatment of M. abscessus pulmonary disease.

Methods
The records of 336 patients with M. abscessus pulmonary disease who were admitted to Shanghai Pulmonary Hospital from January 2018 to December 2020 were retrospectively analyzed. A total of 164 patients received a linezolid-containing regimen and 172 controls did not. The effectiveness, safety, antibiotic susceptibility profiles, outcomes, culture conversion, cavity closure, and adverse reactions were compared in these two groups.

Results
The two groups had similar treatment success (56.1% vs. 48.8%; P > 0.05), but treatment duration was shorter in the linezolid group (16.0 months [inter-quartile ranges, IQR: 15.0–17.0] vs. 18.0 months [IQR: 16.0–18.0]; P < 0.01). The rates of sputum culture conversion were similar (53.7% vs. 46.5%, P > 0.05), but time to conversion was shorter in the linezolid group (3.5 months [IQR: 2.5–4.4] vs. 5.5 months [IQR: 4.0–6.8]; P < 0.01). The linezolid group had a higher rate of cavity closure (55.2% vs. 28.6%, P < 0.05) and a shorter time to cavity closure (3.5 months [IQR: 2.5–4.4] vs. 5.5 months [IQR: 4.0–6.8]; P < 0.01). Anemia and peripheral neuropathy were more common in the linezolid group (17.7% vs. 1.7%, P < 0.01; 12.8% vs. 0.6%, P < 0.01).

Conclusions
The linezolid and control groups had similar treatment success rates. The linezolid group had a shorter treatment duration, shorter time to sputum culture conversion, and higher rate and shorter time to lung cavity closure. More patients receiving linezolid developed anemia and peripheral neuropathy.