bluuebunny/crossref_metadata_2025_split huggingface dataset:
Wavelet-Based Multiscale Flow For Realistic Image Deformation in the Large Diffeomorphic Deformation Model Framework
Authors: Gaudfernau Fleur , Blondiaux Eléonore , Pennec Erwan Le , Allassonnière Stéphanie 
Published: November 2023

Abstract

Estimating accurate high-dimensional transformations remains very challenging, especially in a clinical setting. In this paper, we introduce a multiscale parameterization of deformations to enhance registration and atlas estimation in the Large Deformation Diffeomorphic Metric Mapping framework. Using the Haar wavelet transform, a multiscale representation of the initial velocity fields is computed to optimize transformations in a coarse-to-fine fashion. This additional layer of spatial regularization does not modify the underlying model of deformations. As such, it preserves the original kernel Hilbert space structure of the velocity fields, enabling the algorithm to perform efficient gradient descent. Numerical experiments on three datasets, including abnormal fetal brain images, show that compared to the original algorithm, the coarse-to-fine strategy reaches higher performance and yields template images that preserve important details while avoiding unrealistic features. This highly versatile strategy can easily be applied to other mathematical frameworks for almost no additional computational cost.
A Scoping Review on the Use of Enterprise Social Media for Knowledge Creation and Organizational Learning
Authors: Moumen Mounia 
Published: November 2023

Abstract
Modern societies and advanced economies use knowledge as a catalyst for change and development. Simultaneously, information technology (IT) is regarded as an enabler of communication, knowledge sharing, and learning in the workplace. Enterprise social media (henceforth ESM) are IT tools that initiate social interaction, connect professionals, and facilitate learning in the workplace. While the usage of ESM is growing, existing research on the subject is still limited, and even required, especially in developing countries like Morocco. On the other hand, organizational learning is a challenging subject of research, particularly when it is studied in relation to information technology usage in the workplace. The purpose of this article is to provide a comprehensive overview of relevant research concerning the use of ESM for organizational learning, and knowledge creation and sharing, with regard to work performance and organizational change. We adopted Arksey and O'Malley's five-stage framework for conducting a scoping review.
Retinal giant cyst treated by the scleral buckling procedure : a case report
Authors: Wang Yifan , Cao Xiaolu , Jia Peipei , Yuan Lifei , Wang Yanhui , Liu Jianan , An Jing , Wang Lifei 
Published: November 2023

Abstract

Background: Retinal cysts are rare lesions of the fundus that are essentially fluid-filled cavities located or originating in the retina, with a diameter larger than the normal retinal thickness. To date, there have been few case reports of giant retinal cyst hemorrhage with retinoschisis.
Case presentation: A 32-year-old woman with no other medical history complained of decreased vision for 3 days after a severe cough. The best-corrected visual acuity in the right eye was 0.5. A comprehensive ophthalmological examination including slit lamp fundoscopy, ultrasound scan of the eye, optical coherence tomography (OCT) scan, and orbital magnetic resonance imaging (MRI) was performed. Ophthalmological examination revealed grade III anterior chamber blood cells and grade III vitreous hemorrhage in the right eye and a large herpetic cyst on the nasal side of the retina. The cyst projected into the vitreous, with a large amount of hemorrhage vaguely visible within it. The cyst was clearly visible, and a superficial retinal limiting detachment was observed around it. Ultrasound showed a retinal cyst with retinal detachment in the right eye. Laboratory test results were unremarkable. After three months of conservative treatment, the patient's intracystic hemorrhage was significantly absorbed, but the size of the cyst cavity did not show any significant change. Scleral buckling with external compression combined with external drainage of the intracystic fluid was performed, the patient's visual acuity was gradually restored to a normal 1.0 after the operation, and the retina appeared flattened. The patient was finally diagnosed with a giant retinal cyst with retinoschisis in the right eye. The presumed cause was heavy coughing leading to rupture and hemorrhage of the retinal cyst, similar to the mechanism of rupture of an arterial dissection. To the best of our knowledge, this case of retinal cyst rupture and hemorrhage caused by heavy coughing with good recovery after external surgical treatment has never been reported before.
Conclusions: Giant cystic retinal hemorrhage with retinoschisis is very rare. Orbital magnetic resonance imaging and ocular B-scan ultrasound are essential for its diagnosis, and the selection of an appropriate surgical procedure is necessary to maximize the benefit for affected patients.
Bioactive Recovery from Watermelon Rind Waste Using Ultrasound-Assisted Extraction
Authors: Zia Sania , Khan Moazzam Rafiq , Aadil Rana Muhammad , Medina-Meza Ilce Gabriela 
Published: November 2023

Abstract
In response to the imperative to address food waste and promote environmental sustainability, this study investigates the transformation of watermelon rind waste, an agrowaste, into a valuable resource. We extract polyphenols and antioxidants from freeze-dried watermelon rind (WMR) across four cultivars (Crimson Sweet, Black Prince, Black Chairman, and Sugar Baby) using ultrasound-assisted extraction (UAE). Solvent selection, based on a preliminary experiment, is optimized through response surface methodology (RSM), fine-tuning solvent concentration and sonication time. RSM effectively models our responses (R2> 0.90), confirming its suitability for optimization. Applying the optimized parameters (79.8% solvent concentration and 20 minutes of sonication) to various cultivars yields rich bioactive extracts. This optimization is vital for extracting polyphenols and antioxidants as sustainable alternatives to synthetic antioxidants, bolstering food stability. Watermelon rind also offers a distinct profile of fatty acids and phytosterols, ideal for diverse applications in food, pharmaceuticals, nutraceuticals, and industry.
Practical Applications: Watermelon rinds are valuable sources of bioactive molecules with potential for pharmaceutical and nutraceutical applications. The application of ultrasound-assisted extraction (UAE) to retrieve polyphenols and antioxidants from watermelon rinds presents an ecofriendly and efficient approach with practical applications. Within the food industry, these compounds can serve as natural alternatives to synthetic antioxidants. By enhancing oxidative stability, the use of these bioactive compounds extends the shelf life of food items while improving their nutritional quality. Moreover, specific fatty acids and phytosterols in watermelon rinds open avenues in pharmaceuticals, nutraceuticals, and functional ingredients. These compounds can be integrated into dietary supplements and functional foods, promoting health among consumers. In summary, this study's optimized extraction methods yield bioactive compounds with practical value. These compounds enhance food quality and meet consumer preferences while driving innovation across various industries, from food production to pharmaceuticals and nutraceuticals.
Assessing Preferences for Addressing Religion and Spirituality in a Recovery Program for Adults with Serious Mental Illness
Authors: Matsuura Taiqi , Klee Anne , MDiv Holly Heikella , Cooke James , Rosenheck Robert 
Published: November 2023

Abstract

Religion and Spirituality (R/S) are recognized components of recovery-oriented mental health services, but a clinically focused R/S needs assessment tool for Veterans with Serious Mental Illness (SMI) has not been developed. A questionnaire including 39 items was developed by experienced chaplains and mental health clinicians and administered to 110 participants in a recovery-oriented VA program. Altogether 40 (37%) said they would like R/S issues to be a greater part of their treatment (i.e. very or extremely). A screening tool to identify Veterans for referral to R/S focused interventions was developed based on the selection of the five items most strongly loading on the strongest factor in a factor analysis. This R/S survey of SMI adults suggests that over one-third of participants in a recovery-oriented program would like more R/S emphasis in their treatment. Factor analysis showed desire for uplifting religious/spiritual communityto be the predominant factor.
Diarrhea syndrome: current aspects of differential diagnosis and treatment at the stage of primary health care
Authors: Trukhan D. I. , Degovtsov E. N. , Goloshubina V. V. , Popilov M. A. 
Published: November 2023

Diarrhea is one of the most common syndromes encountered in the practice of a general practitioner, a general practitioner, a pediatrician at the stage of providing primary health care, as well as a gastroenterologist, an infectious disease specialist and a surgeon at the stage of providing specialized medical care. The first part of the review is devoted to the differential diagnosis of diarrhea, the main pathological conditions and nosological forms in which the development of diarrhea syndrome is possible in real clinical practice are considered.The second part of the review is devoted to a promising active method in gastroenterological practice-enterosorption. The main requirements for modern enterosorbents are met by the domestic enterosorbent based on silica (colloidal silicon dioxide) Polysorb® MP. Its properties are considered, data of comparative studies with other enterosorbents are given. The studies demonstrating the efficacy and safety of the use of enterosorbent Polysorb® MP in the complex therapy of infectious diarrhea in adult patients and in pediatric practice are presented. Diarrhea is one of the most common gastrointestinal symptoms in the new coronavirus infection COVID-19. A number of studies have noted the effectiveness of the use of colloidal silicon dioxide (Polysorb® MP) in the complex treatment of adults and children with COVID-19 and as part of the post-COVID syndrome. The use of Polysorb® MP helps to reduce the viral load in the intestine, reduce diarrhea and other clinical symptoms of gastrointestinal lesions in COVID-19.Availability of modern effective and safe enterosorbent Polysorb® MP in the arsenal of a doctor at the stage of providing primary health care will optimize drug therapy in patients with diarrhea syndrome and other comorbid somatic pathologies.
Functional dyspepsia: modern pathogenetic aspects and therapeutic approaches
Authors: Egorov I. V. 
Published: November 2023

Functional dyspepsia, affecting up to 20% of individuals worldwide, remains both a cause of decreased activity of patients’ daily life and an obvious economic burden due to healthcare costs. Despite extensive research, the etiology of dyspepsia is unknown in most patients. Intestinal motility dysfunction has long been considered the major culprit, but recent studies suggest that immune pathophysiological and molecular effects in the duodenum are far more likely predisposing factors. Eosinophilia and an increase in mast cells in both the duodenum and gastric mucosa are identified in most patients with this disease. More and more data on the significant role of impaired paracellular permeability of the intestinal mucosa are now available. It is associated with subclinical inflammation in the submucosal layer in patients with functional dyspepsia. This explains the poor effectiveness of the treatments taken. The evidence from practice suggests that symptoms persist or return after eradication therapy in most patients. Proton pump inhibitors and antidepressants do not ease postprandial distress syndrome. Montelukast and cromolyn therapy has been proposed, but this approach is not yet widely popular. Therefore, there is an obvious need in finding other therapeutic approaches. One of them is the increased use of prokinetics, the most recent of which is acotiamide. Its mechanism of action is similar to that of prior generation prokinetics (inhibition of acetylcholinesterase activity), but is distinguished by the absence of impact on dopaminergy, due to which the drug has far fewer side effects. In addition, its effect on the production of ghrelin, which physiological role is being actively studied, is discussed.
Mono- or multistrain probiotics? Comparative clinical study of different therapeutic strategies for infantile colic
Authors: Novikova V. P. , Magamedova D. M. , Blinov A. E. , Varlamova O. N. , Kondratieva A. E. 
Published: November 2023

Introduction. The highest level of evidence for the treatment of colic in breastfed infants is with L. reuteri monoprobiotic therapy. Recently multistrain probiotics have been used to treat colic.Аim. Is to evaluate the effectiveness of various strategies for the treatment of infantile colic, including monoand multistrain probiotics.Materials and methods. A total of 110 infants aged 1–5 months with colic and 20 healthy infants were examined. The effectiveness of treatment was assessed in three groups of infants with colic: Group 1 consisting of 30 children who received BioGaia Probiotic drops for baby (L. reuteri); Group 2 consisting of 40 children who received Bac-Set Baby multistrain probiotic, and Group 3 consisting of 40 children who received symptomatic therapy. The estimated parameters included duration of crying, fecal levels of zonulin measured by ELISA assays, and gut microbiota composition.Results. Children with colic had longer crying duration compared to healthy children, higher levels of zonulin in the stool and differences in the microbiota. In group 2, colic relief occurred on average within 5 days, which is significantly faster than in groups 1 and 3 (10 and 12 days, respectively). In group 2, colic relief occurred in the majority of children (87.5%), the differences with groups 1 and 3 were statistically significant (53.3% and 10% of children, respectively). Also in group 2 there was a decrease in the level of zonulin by 41.4% from the initial level, in group 1 – by 40.1%, in group 3 – by 10.8%. Group 2 has also showed positive changes in the microbiota.Discussion. The results confirm the effectiveness of multistrain probiotics in the treatment of colic.Conclusions. Bac-Set Baby multistrain probiotic proved to be more effective than BioGaia Probiotic drops for baby monostrain probiotic and symptomatic therapy in the relief of infantile colic. The effect of Bac-Set Baby is associated with its ability to normalize the intestinal microbiota and reduce the permeability of the intestinal wall.
Experience of using an interferon inducer in the prevention of influenza and acute respiratory viral infections in children
Authors: Borisova O. V. , Bochkareva N. M. , Polezhaeva N. S. , Yashkina O. N. , Tsareva N. G. , Gadelshina D. M. 
Published: November 2023

Introduction. Taking into account the changeable viral landscape of pathogens, the persistence of seasonal morbidity at a high level, and the refusal of a number of parents to be vaccinated against influenza, the interest of scientists and practitioners in the use of endogenous interferon inducers is increasing. Studies by domestic authors have proven that Kagocel® is highly effective in the prevention and treatment of influenza and other ARIs.Aim. Evaluation of the efficacy and safety of Kagocel® for the prevention of influenza and ARIs in children aged 3–18 years old on an outpatient basis during the epidemic rise of respiratory viral infections in 2022–2023.Materials and methods. A prospective comparative analysis of cases of prevention of influenza and ARIs by Kagocel® in children was carried out: group 1 – main (n = 32). Kagocel® was prescribed according to the scheme for a month. The comparison group consisted of patients vaccinated against influenza, who did not receive drugs for the prevention of acute respiratory viral infections: group 2 – comparison (n = 28).Results and discussion. The index of preventive efficacy of Kagocel® was 3.0, the efficiency ratio was quite high – 66.7%. The elimination of the main clinical symptoms of the disease was noted on average by the 2nd–3rd day of illness. Prophylactic administration of the drug allowed to reduce the incidence of influenza and ARIs by 3 times; reduce the number of complications from these diseases by 4 times. The economic feasibility of prophylaxis with Kagocel® has been proven, direct costs for the treatment of one patient have decreased by 3.6 times. The interferon inducer was well tolerated, no side effects of the drug were detected.Conclusion. Endogenous interferon inducer Kagocel® can be used for prophylactic purposes during the seasonal rise in the incidence of influenza and ARIs.
Actual nutrition of young children: how to make what you want real
Authors: Gurova M. M. , Protsenko E. A. 
Published: November 2023

Introduction. The nutrition of young children determines the vector of the physical and neuro-psychological development of the child, forms the characteristics of eating behavior.Aim. To study the features of the nutritional practice of young children living in Belgorod, and to evaluate the success of the implementation of the Program for optimizing the nutrition of children aged 1 to 3 years in the Russian Federation in pediatric practice.Materials and methods. We interviewed 307 women with young children born at 38–41 weeks of gestation with an Apgar score of at least 8 points. In addition, we developed a questionnaire that allows retrospectively assessing the regime and diet of young children.Results. We identified the following problems of young children nutrition: non-compliance with the diet – only 18.1% of the respondents strictly adhered to the regime, the use of confectionery and sweets as snack products in almost a third of children (27%) which were introduced into the diet in 44% of children aged 1–2 years, and in 43% of children after 2 years. According to the survey data, 38.2% of respondents used industrial food products for young children in the form of milk-based drinks, but the duration of their use was limited to the second year of life. 14% of children used other industrial food products for young children.Discussion. The presented dietary habits of children lead to the formation of incorrect eating habits, aggravating the imbalance of the diet, increasing the risk of health problems.Conclusion. The results of the study show the need for further work on the active implementation of the existing recommendations for optimizing the nutrition of young children. The FrutoNyanya brand includes a wide selection of industrially produced baby food products, allowing you to achieve a wide variety, but also healthy food products.
Glycemic control parameters in children with type 1 diabetes treated with fast-acting insulin aspart domestic biosimilar by continuous subcutaneous infusion
Authors: Platonov V. V. , Dubinina T. A. , Patrakeeva E. M. , Taraikovich A. A. 
Published: November 2023

Introduction. Type 1 diabetes (T1D) is a chronic autoimmune disease requiring constant insulin therapy under regular continuous monitoring of glycemic parameters. The use of domestic insulin bioanalogues in CSII therapy is currently not sufficiently covered in the literature.Aim. To evaluate glycemic control parameters in children with T1D treated with the domestic fast-acting insulin aspart biosimilar by CSII.Materials and methods. Retrospective study was carried out on the basis of K.A. Raukhfus center St. Petersburg State Medical and Biomedical Center VMT. Fifty-five children with T1D aged 6 to 17 years (mean age 12 ± 4) were examined, including 29 boys (52.7%, mean age 11 ± 3 years) and 26 girls (47.3%, mean age 13 ± 4 years). Insulin therapy was carried out by systems of CSII Glycemic parameters were monitored by continuous and flash glycemic monitoring systems. The center visits frequency was once a month.Results. During dynamic follow-up after 3 and 6 months, children showed statistically significant (p < 0.05) improvement in glycemic control parameters–decrease in HbA1c level from 8.0 ± 1.8% to 7, 1 ± 1.2% and 6.8 ± 0.6%, increase in TIR from 60.4 ± 20.6% to 71.5 ± 13.0% and 75.9 ± 9.4%, decrease in TAR from 31.1 ± 22.1% to 23.0 ± 12.8% and 20.3 ± 9.3%, decrease in TBR from 9.1 ± 8.2% to 5.8 ± 4.3% and 4.1 ± 1.8%, and decrease in CV from 40.0 ± 9.1% to 33.7 ± 6.7% and 32.5 ± 5.6%.Discussion. The use of domestic biosimilar insulin aspart in insulin pumps iis associated with significant improvement in glycemic control in children and adolescents with T1D. Dynamic observation together with therapeutic education contribute to the maintenance of the achieved parameters at a high level.Conclusions. Therapy with the domestic fast-acting insulin aspart biosimilar by CSII allows achieving target glycemic control in children with T1D.
Microscopic colitis of incomplete collagen type in combination with lactase deficiency
Authors: Volchkova E. A. , Legkova K. S. , Ardatskaya M. D. 
Published: November 2023

The number of patients complaining of indigestion is increasing every year. Made a significant contribution to this the COVID-19 pandemic, which has been going on for almost 3 years, led to this, the drugs used to treat the infection and its complications have a negative effect on the gastrointestinal tract, not to mention the most damaging effect of the virus. Against the backdrop of an increasing number of patients with indigestion as a result of COVID-19, it is important not to forget about other diseases that do not lie on the surface and do not always have typical manifestations. A relatively young disease, but increasingly common among patients with diarrhea, is microscopic colitis (MC). This article presents a clinical case of microscopic colitis of incomplete collagen type in combination with lactase deficiency. MC is a chronic inflammatory bowel disease of unknown etiology, characterized by chronic watery diarrhea, the absence of macroscopic signs of colon damage in the presence of specific pathomorphological changes. Based on the histological result, two main forms are distinguished: collagenous and lymphocytic colitis. According to the latest data presented in the European guidelines, the overall prevalence of MC is 119.4 cases per 100 thousand people, and the incidence is 11.4 cases per 100 thousand population per year. The progressive increase in the incidence, and even the prevalence of MC over patients with inflammatory bowel disease (IBD) in some countries in the group over 60 years of age, has led to an increase in clinical interest in this problem, improvement of diagnostic methods and revision of clinical guidelines in February 2021. Given the increase in the incidence of MC, the difficult diagnostic search for this diagnosis, age variation, and the description of clinical cases that differ from the average portraits of a “typical patient” with microscopic colitis are of clinical interest.