bluuebunny/crossref_metadata_2025_split huggingface dataset:
Evaluasi User Experience Pada Mobile Legends: Bang Bang Menggunakan Metode Cognitive Walkthrough
Authors: Retno Sari Febrian  , Maryanah Safitri  
Published: December 2023

Video game online memerlukan perangkat game yang tersambung ke internet agar berfungsi. Dalam game digital, interface juga dikenal sebagai antarmuka game yang memungkinkan pemain untuk berinteraksi dengan game tersebut, antarmuka game ini berisi semua simbol, teks, gambar, dan petunjuk. Pengembang harus mengevaluasi antarmuka yang dihasilkan untuk mendapatkan antarmuka yang bagus. Game mobile legends: bang bang merupakan salah satu game smartphone online yang telah diunduh oleh lebih dari 500 juta pengguna dengan rating 3,6 pada aplikasi play store, kurangnya pemahaman beberapa ikon atau Instruksi menjadi masalah dalam game ini. cognitive walkthrough adalah proses penilaian kegunaan yang terstruktur secara teoritis yang berfokus pada aktivitas kognitif pengguna, terutama saat melakukan tugas. Mempersiapkan, Menganalisis, dan Tindak lanjut adalah tiga langkah dalam cognitive walkthrough. Pengumpulan data penelitian ini dibagi menjadi dua kategori yaitu pengguna yang sudah lama memainkan game mobile legends (lebih dari lima bulan) dan pengguna baru yang belum pernah memainkan atau memainkan game mobile legends kurang dari empat bulan. Tujuan penelitian ini untuk melihat pengalaman pengguna saat memainkan game ini, masalah umum yang dihadapi dan rekomendasi perbaikan. Hasil dari keseluruhan matrix menunjukan bahwa pada matrix A tidak ada masalah yang serius, matrix B menunjukan perlunya perhatian lebih pada tipe masalah P, S, dan T. Pada matrix C dan E menunjukan bahwa tipe masalah Text and Icon merupakan tipe masalah yang paling kurang dipahami oleh pengguna.
Pengaruh Kualitas Produk, Kualitas Pelayanan, dan Harga Terhadap Keputusan Pembelian pada Toko Online TikTok Shop
Authors: Karina Mona , Sari Nunung Eka 
Published: December 2023

This research uses descriptive methods with a quantitative approach. Primary data was collected through a questionnaire containing a structured question to evaluate the variables studied. Sampling in the study using non-probability sampling techniques with a sample size of 171 out of 300 people in the population with a tolerable error rate of around 5%. The results showed that the product quality variable had a positive but insignificant effect on purchasing decisions. Service quality variables have a positive but insignificant effect on Purchasing Decisions. The price variable has a positive and significant effect on Purchasing Decisions. The results of the Determination Coefficient test found that the purchasing decision variable is influenced by 54% by Product Quality, Service Quality, and Price. While the remaining 46% is influenced by other factors not examined in this study.
Abstrak
Tujuan penelitian ini untuk mengukur pengaruh kualitas produk, kualitas pelayanan dan harga terhadap keputusan pembelian di toko daring TikTok Shop. Penelitian ini menggunakan metode deskriptif dengan pendekatan kuantitatif. Menggunakan data primer yang diperoleh melalui kuisioner yang berisi daftar pertanyaan terstrukur untuk mengevaluasi variabel-variabel yang diteliti. Pengambilan sampel dalam penelitian menggunakan teknik non probability sampling dengan jumlah sampel sebesar 171 orang dari 300 orang pada populasi dengan tingkat kesalahan yang ditoleransi berkisar 5%. Hasil penelitian mendapatkan bahwa variabel kualitas produk berpengaruh positif namun tidak signifikan terhadap keputusan pembelian. Variabel kualitas pelayanan berpengaruh positif namun tidak signifikan terhadap keputusan pembelian. Variabel harga berpengaruh positif dan signifikan terhadap keputusan pembelian. Serta dari hasil uji koefesien determinasi didapatkan variabel keputusan pembelian dipengaruhi sebesar 54% oleh kualitas produk, kualitas pelayanan dan harga. Sedangkan sisanya sebanyak 46% dipengaruhi oleh faktor-faktor lain yang tidak diteliti dalam penelitian ini.
Kata Kunci: Tiktok Shop, Produk, Pelayanan, Harga, Keputusan Pembelian
Deep vein thrombosis and pulmonary embolism: a prospective, observational study to evaluate diagnostic performance of the Tina-quant D-Dimer Gen.2 assay
Authors: Bertsch Thomas , Behringer Wilhelm , Blaschke Sabine , Body Richard , Davidson Simon , Müller-Olling Mirco , Guo Ge , Rieger Anna , Wahl Annika , Horner Daniel , Sun Yuli , Turnes Lucia , Sonner Ulrich , Hoffmann Michael 
Published: December 2023

BackgroundD-Dimer testing is a diagnostic tool for exclusion of deep vein thrombosis (DVT) and pulmonary embolism (PE). This study evaluated the diagnostic performance of the Tina-quant® D-Dimer Gen.2 assay (Roche Diagnostics International Ltd, Rotkreuz, Switzerland) in patients with low/intermediate pre-test probability of DVT/PE using standard, age-, and clinical probability-adjusted cut-offs.MethodsIn this prospective, observational, multicenter study (July 2017–August 2019), plasma samples were collected from hospital emergency departments and specialist referral centers. DVT/PE was diagnosed under hospital standard procedures and imaging protocols. A standard D-dimer cut-off of 0.5 µg fibrinogen equivalent units (FEU)/ml was combined with the three-level Wells score; cut-offs adjusted for age (age × 0.01 µg FEU/ml for patients &gt;50 years) and clinical probability (1 µg FEU/ml for low probability) were also evaluated. An assay comparison was conducted in a subset of samples using the Tina-quant D-Dimer Gen.2 assay and the previously established routine laboratory assay, STA-Liatest D-Di Plus assay (Stago Deutschland GmbH, Düsseldorf, Germany).Results2,897 patients were enrolled; 2,516 completed the study (DVT cohort: 1,741 PE cohort: 775). Clinical assessment plus D-dimer testing using the standard cut-off resulted in 317 (DVT) and 230 (PE) false positives, and zero (DVT) and one (PE) false negatives. Negative predictive value (NPV) was 100.0% (95% confidence interval [CI]: 99.7%–100.0%) and 99.8% (95% CI: 98.8%–100.0%) for DVT and PE, respectively. After age-adjustment, NPV was 99.9% (95% CI: 99.6%–100.0%) and 99.1% (95% CI: 97.8–99.7) for DVT and PE, respectively. False positive rates decreased (&gt;50%) in clinical probability-adjusted analyses vs. primary analysis. In the assay comparison, the performances of the two assays were comparable.ConclusionThe Tina-quant D-Dimer Gen.2 assay and standard D-dimer cut-off level combined with the three-level Wells score accurately identified patients with a very low probability of DVT/PE.
Deep learning techniques for isointense infant brain tissue segmentation: a systematic literature review
Authors: Mhlanga Sandile Thamie , Viriri Serestina 
Published: December 2023

IntroductionTo improve comprehension of initial brain growth in wellness along with sickness, it is essential to precisely segment child brain magnetic resonance imaging (MRI) into white matter (WM) and gray matter (GM), along with cerebrospinal fluid (CSF). Nonetheless, in the isointense phase (6-8 months of age), the inborn myelination and development activities, WM along with GM display alike stages of intensity in both T1-weighted and T2-weighted MRI, making tissue segmentation extremely difficult.MethodsThe comprehensive review of studies related to isointense brain MRI segmentation approaches is highlighted in this publication. The main aim and contribution of this study is to aid researchers by providing a thorough review to make their search for isointense brain MRI segmentation easier. The systematic literature review is performed from four points of reference: (1) review of studies concerning isointense brain MRI segmentation; (2) research contribution and future works and limitations; (3) frequently applied evaluation metrics and datasets; (4) findings of this studies.Results and discussionThe systemic review is performed on studies that were published in the period of 2012 to 2022. A total of 19 primary studies of isointense brain MRI segmentation were selected to report the research question stated in this review.
The future of myelodysplastic syndrome—patient priorities and outcomes that matter
Authors: Poynton Matthew , Gilmour-Hamilton Catriona , Dale-Harris Isabella , Clarke Evelyn , Stanworth Simon , Murphy Mike , Roy Noémi 
Published: December 2023

BackgroundWithout a definitive curative option available to many patients, learning to live with myelodysplastic syndrome (MDS) and manage symptoms effectively becomes a priority in their care. Anaemia is an almost universal feature of MDS. Individuals suffer differently and better individualisation of care is needed. Most MDS patient information offers scant appreciation for disease heterogeneity, variable response to treatment and each patient’s likely trajectory.MethodsWe undertook a two-part, online workshop to discuss what matters most to people living with MDS. Patients generated questions about their condition which they felt should be addressed by research or change how their care is delivered. Patients voted on the importance of each topic, creating a “prioritised” list of issues.ResultsFourteen participants of varying age and experience took part raising 56 unique questions under the themes of: prognosis; end of life; treatment; supportive care; medical staff training; diagnosis and communication. These reflect the symptoms of MDS, improving quality of life (QoL) and communication.DiscussionAlthough haemoglobin (Hb) levels have correlation to QoL, it is widely reported that other factors are important in determining QoL and need for transfusions varies despite stable Hb levels. We showed that Hb level and the need for transfusions is not comparable between different patients and even non-comparable over time meaning that the maximal benefit and timing of transfusions cannot be determined from Hb alone. This workshop highlighted patient dissatisfaction with the “numbers-led” approach and the need for an alternative method to determine when to transfuse.
Case report: Thrombolysis in patients with acute ischemic stroke and cerebral cavernous malformation
Authors: Lin Jie , Weng Xiongpeng , Zheng Jing , Wu Saizhen , Bao Qiongqiong , Peng Feifei , Huang Yanbin 
Published: December 2023

BackgroundCerebral cavernous malformation (CCM) is a rare disease associated with a latent risk of intracranial hemorrhage. However, due to limited evidence, the safety of recommending intravenous tissue plasminogen activators for patients with acute stroke and CCM remains uncertain.MethodsOur study identified five patients with acute stroke and CCM treated between 2017 and 2023 across two hospitals. A comprehensive literature review was conducted, incorporating three similar case reports and two retrospective studies.ResultsAmong 30 patients reviewed, three exhibited symptomatic intracranial hemorrhage, two of whom were women. Additionally, three patients presented with calcification in their CCM, with two experiencing symptomatic intracranial hemorrhage.ConclusionThe observed incidence of symptomatic intracranial hemorrhage following intravenous tissue plasminogen activator administration appears to be elevated in patients with CCM. Therefore, before thrombolysis, a thorough evaluation of personalized risk–benefit ratios is crucial. Furthermore, conducting further research involving multiple centers and larger sample sizes is imperative to advance our understanding in this area, especially in identifying hemorrhage risk factors.
Enhancing date seed phenolic bioaccessibility in soft cheese through a dehydrated liposome delivery system and its effect on testosterone-induced benign prostatic hyperplasia in rats
Authors: Mohammed Dina Mostafa , El-Messery Tamer M. , Baranenko Denis A. , Hashim Mahmood A. , Boulkrane Mohamed Said , El-Said Marwa M. 
Published: December 2023

IntroductionThe consumption of dairy products, including soft cheese, has been associated with numerous health benefits due to their high nutritional value. However, the phenolic compounds bioaccessibility present in soft cheese is limited due to their poor solubility and stability during digestion. So, this study aimed to develop an innovative soft cheese enriched with date seed phenolic compounds (DSP) extracted ultrasonically and incorporated into homogeneous liposomes and study its attenuation effect on testosterone-induced benign prostatic hyperplasia (BPH) in rats.MethodsDate seed phenolic compounds were extracted using 98 and 50% ethanol along with water as solvents, employing ultrasonication at 10, 20, and 30-min intervals. The primary and secondary DSP-liposomes were prepared and dehydrated. The particle size, zeta potential, encapsulation efficiency, and morphology were measured. Incorporating dehydrated liposomes (1–3% w/w) into soft cheese and their impact on BPH using male Sprague–Dawley rats was assessed. After inducing BPH, rats were fed a cheese diet with dehydrated DSP-liposomes. Over 8 weeks, parameters including nutrition parameters, prostate enlargement analysis, biochemical parameters, hormones level, oxidative stress, and cytokines were analyzed.Results and DiscussionThe results showed that ultrasound-assisted extraction effectively reduced the extraction time and 30 min extraction EtOH 50% was enough to extract high yield of phenolic compounds (558 mg GA/g) and flavonoids (55 mg qu/g) with high antioxidant activity (74%). The biological results indicate that prostate weight and prostate index% were diminished in the treatment groups (1 and 2) compared to the BPH control group. The high antioxidant content present in the DSP-liposomes acted as the catalyst for suppressing the responses of the inflammatory cytokines, inhibiting the anti-inflammatory IL-10 production, and suppressing the elevated levels of lipid peroxidation products compared to the BPH group.ConclusionThe treatment group (2) supplemented with dehydrated secondary DSP-liposomes exhibited the most significant variance (p &lt; 0.05) as opposed to the BPH group. Liposomal encapsulation was proved to be a feasible approach for administering DSP in soft cheese, thereby establishing new functional food category possessing prophylactic properties against the advancement of BPH in rats.
Prehabilitation of dysphagia in the therapy of head and neck cancer- a systematic review of the literature and evidence evaluation
Authors: Vester Sarah , Muhr Anna , Meier Johannes , Süß Christoph , Kummer Peter , Künzel Julian 
Published: December 2023

BackgroundPrehabilitation is becoming increasingly important in oncology because of the significant survival benefits that the reduction of malnutrition provide. Specifically, tumor- and therapy-related dysphagia leads to malnutrition in more than half of head and neck tumor patients. Studies describe the positive effects of an early onset of swallow-specific prehabilitation on the protection of the swallowing function. This paper intents to evaluate the existing evidence on the efficacy of preventive forms of swallowing therapy.MethodsA systematic literature search was performed in February 2022 in the Cochrane Library, MEDLINE via PubMed, and ClinicalTrials.gov databases for randomized controlled trials investigating preventive swallowing therapy in head and neck tumor patients. This Procedure complies with the PRISMA statement. The RCTs were evaluated by using the PEDro Scale and the Cochrane Risk of Bias tool RoB2.ResultsFive randomized-controlled trials with 423 participants were identified. Four Studies showed moderate to high quality in the PEDro analysis, one showed less. The risk of bias was high in all studies because there was no possibility for blinding and there were high dropout rates. Heterogeneity in interventions, measurement instruments, measurement time points, and outcomes limits a general statement about which swallowing exercises are suitable for the prevention of dysphagia in head and neck tumor patients. Evidence is provided for short-term effects (≤24 months) on functional aspects of swallowing and quality of life. Overall, a decreasing adherence over time was observed in the intervention groups.DiscussionInitial studies describe swallowing-specific prehabilitation programs in head and neck tumor patients as effective, at least in the short term, whereas long-term effects need to be further investigated. At the current time the evidence base for clear recommendations does not appear to be sufficiently high and studies share a high risk of bias. Further well-designed research, especially considering the conditions in the national health care system, is needed.OtherThere was no funding and no registration.
The neural correlates of value hierarchies: a prospective typology based on personal value profiles of emerging adults
Authors: Xie Jia-Qiong , Tian Yun , Hu Jia , Yin Ming-Ze , Sun Ya-Dong , Shan Yan-Jie , Chen Ke , Feng Gang , Qiu Jiang 
Published: December 2023

IntroductionValue hierarchies, as motivational goals anchored in the self-schema, may be correlated with spontaneous activity in the resting brain, especially those involving self-relevance. This study aims to investigate the neural correlates of value hierarchies from the perspective of typology.MethodsA total of 610 Chinese college students (30.31% women), aged 18 to 23, completed the personal values questionnaire and underwent resting-state functional magnetic resonance imaging.ResultsThe latent profile analysis revealed three personal value profiles: traditional social orientation, modernized orientation, and undifferentiated orientation. Neuroimaging results revealed that individuals with modernized orientation prioritized openness to change value, and this personal-focus is related to the higher low-frequency amplitude of the posterior insula; individuals with traditional social orientation prioritized self-transcendence and conservation values, and this social-focus is related to the stronger functional connectivity of the middle insula with the inferior temporal gyrus, temporal gyrus, posterior occipital cortex, and basal ganglia, as well as weaker functional connections within the right middle insula.DiscussionTaken together, these findings potentially indicate the intra-generational differentiation of contemporary Chinese emerging adults’ value hierarchies. At the neural level, these are correlated with brain activities involved in processing self- and other-relevance.
Screen time and addictive use of gaming and social media in relation to health outcomes
Authors: Burén Jonas , Nutley Sissela B. , Thorell Lisa B. 
Published: December 2023

IntroductionThis study examined associations between screen time and addictive use (i.e., heavy involvement and negative consequences) of gaming and social media, and their independent effects on health outcomes.MethodsSurvey data were collected from 2,265 participants (mean age = 21.57). Internet Gaming Disorder (IGD) and Social Media Disorder (SMD) were measured with the Gaming and Social Media Questionnaire (GSMQ-9), with separate measures for heavy involvement and negative consequences. Screen time was measured by weekly hours of gaming and social media. Assessed health outcomes were psychological problems, low self-concept, social problems, sleep problems, and sleep time.ResultsScreen time and addictive use were significantly associated for both gaming and social media, with associations being stronger for symptoms of heavy involvement compared to symptoms of negative consequences. However, despite significant associations, a substantial proportion of the participants with a high screen time did not meet any or just one symptom of addiction. More importantly, it was primarily negative consequences that had independent effects on health outcomes, except for sleep. High levels of heavy involvement in gaming, were even related to lower, not higher, levels of psychological problems.ConclusionThe present findings study show that screen time is a poor indicator of addictive use of gaming and social media. Given that it was primarily negative consequences of gaming or social media that had effects on health outcomes, our study also emphasizes the need to distinguish between different types of addictive use and to further examine the diagnostic validity of the nine IGD symptom criteria.
Life expectancy inequalities between regions of China 2004–2020: contribution of age- and cause-specific mortality
Authors: Zhang Leyi , Sun Lijuan 
Published: December 2023

BackgroundChina's rapid economic and social development since the early 2000s has caused significant shifts in its epidemiological transition, potentially leading to health disparities across regions.ObjectivesThis study employs Life Expectancy (LE) to assess health disparities and trends among China's eastern, central, and western regions. It also examines the pace of LE gains relative to empirical trends and investigates age and causes of death mortality improvement contributing to regional LE gaps.Data and methodsUsing a log-quadratic model, the study estimates LE in China and its regions from 2004 to 2020, using census and death cause surveillance data. It also utilizes the Human Mortality Database (HMD) and the LE gains by LE level approach to analyze China and its regions' LE gains in comparison to empirical trend of developed countries. The study investigates changes in LE gaps due to age and causes of death mortality improvements during two periods, 2004–2012 and 2012–2020, through the LE factor decomposition method.ResultsFrom 2000 to 2020, China's LE exhibited faster pace of gains compared to developed countries. While men's LE growth gradually aligns with empirical trends, women experience slightly higher growth rates. Regional LE disparities significantly reduced from 2004 to 2012, with a marginal reduction from 2012 to 2020. In the latter period, the changing LE gap aligns with expected trends in developed countries, with all Chinese regions surpassing empirical estimates. Cardiovascular diseases and malignant neoplasms emerged as the primary contributors to expanding regional LE gaps, with neurological disorders and diabetes playing an increasingly negative role.ConclusionLE disparities in China have consistently decreased, although at a slower pace in recent years, mirroring empirical trends. To further reduce regional LE disparities, targeted efforts should focus on improving mortality rates related to cardiovascular diseases, neoplasms, neurological disorders and diabetes, especially in the western region. Effective health interventions should prioritize equalizing basic public health services nationwide.