bluuebunny/crossref_metadata_2025_split huggingface dataset:
The role of leadership in organizational learning in multinational companies
Authors: Hekneby Torbjørn , Olsen Trude Høgvold 
Published: January 2024

Purpose
This paper aims to conceptualize the role of leadership in organizational learning processes in multinational companies (MNCs). The authors present a model describing how managers in an MNC facilitated transitions between sub-processes of organizational learning at several organizational levels.

Design/methodology/approach
The authors collected data from the plants of a global process company in Norway, Brazil and China. Observation, in-depth interviews and archival material enabled one to reconstruct the organizational learning process over a period of 30 years as the company developed its own tailor-made improvement programme.

Findings
Based on the data, the authors describe the role of leadership in linking the sub-processes of organizational learning as orchestration, sponsoring and persistence. Orchestration included creating faith and optimism and designing the organization to allow close cooperation between operators and managers in the sub-process of experimenting. This eased transferring and institutionalizing in the global organization. Sponsoring included structural changes to support transferring and the demonstration of dedication to improvement programme values. These factors were important for institutionalizing. Persistence involved the continuous focus on adjustment of the improvement programme, which then facilitated further experimenting.

Originality/value
Firstly, this study suggests that activities and decisions in one sub-process have important implications for the following sub-processes. Secondly, this study indicates that leaders’ role in facilitating the transitions between sub-processes extend beyond their individual traits and behaviour, which previous research had focused on, and includes decisions concerning organizational structure and culture that help link social and organizational learning.
Metabolic engineering of Corynebacterium glutamicum for the production of anthranilate from glucose and xylose
Authors: Mutz Mario , Brüning Vincent , Brüsseler Christian , Müller Moritz‐Fabian , Noack Stephan , Marienhagen Jan 
Published: January 2024

AbstractAnthranilate and its derivatives are important basic chemicals for the synthesis of polyurethanes as well as various dyes and food additives. Today, anthranilate is mainly chemically produced from petroleum‐derived xylene, but this shikimate pathway intermediate could be also obtained biotechnologically. In this study, Corynebacterium glutamicum was engineered for the microbial production of anthranilate from a carbon source mixture of glucose and xylose. First, a feedback‐resistant 3‐deoxy‐arabinoheptulosonate‐7‐phosphate synthase from Escherichia coli, catalysing the first step of the shikimate pathway, was functionally introduced into C. glutamicum to enable anthranilate production. Modulation of the translation efficiency of the genes for the shikimate kinase (aroK) and the anthranilate phosphoribosyltransferase (trpD) improved product formation. Deletion of two genes, one for a putative phosphatase (nagD) and one for a quinate/shikimate dehydrogenase (qsuD), abolished by‐product formation of glycerol and quinate. However, the introduction of an engineered anthranilate synthase (TrpEG) unresponsive to feedback inhibition by tryptophan had the most pronounced effect on anthranilate production. Component I of this enzyme (TrpE) was engineered using a biosensor‐based in vivo screening strategy for identifying variants with increased feedback resistance in a semi‐rational library of TrpE muteins. The final strain accumulated up to 5.9 g/L (43 mM) anthranilate in a defined CGXII medium from a mixture of glucose and xylose in bioreactor cultivations. We believe that the constructed C. glutamicum variants are not only limited to anthranilate production but could also be suitable for the synthesis of other biotechnologically interesting shikimate pathway intermediates or any other aromatic compound derived thereof.
Uncertainties and opportunities in delivering environmentally sustainable surgery: the surgeons' view
Authors: Ledda V. , George C. , Glasbey J. , Labib P. , Li E. , Lu A. , Kudrna L. , Nepogodiev D. , Picciochi M. , Williams I. , Bhangu A. 
Published: January 2024

SummarySurgery is a carbon‐heavy activity and creates a high volume of waste. Surgical teams around the world want to deliver more environmentally sustainable surgery but are unsure what to do and how to create change. There are many interventions available, but resources and time are limited. Capital investment into healthcare and engagement of senior management are challenging. However, frontline teams can change behaviours and drive wider change. Patients have a voice here too, as they would like to ensure their surgery does not harm their local community but are concerned about the effects on them when changes are made. Environmentally sustainable surgery is at the start of its journey. Surgeons need to rapidly upskill their generic knowledge base, identify which measures they can implement locally and take part in national research programmes. Surgical teams in the NHS have the chance to create a world‐leading programme that can bring change to hospitals around the world. This article provides an overview of how surgeons see the surgical team being involved in environmentally sustainable surgery.
Individuals' travel to alcohol outlets: The fallacy of the local bar
Authors: Mehranbod Christina A. , Gobaud Ariana N. , Bushover Brady R. , Morrison Christopher N. 
Published: January 2024

AbstractIntroductionStudies relating alcohol outlet density around homes to alcohol consumption produce mixed results. One possible explanation is that people travel to outlets away from their homes. This study aims to characterise individuals' trips to outlets, describe these trip locations relative to other activities and estimate associations between alcohol outlet density and trips to outlets.MethodsThis cross‐sectional study used 2014–2018 household travel data from the Victoria Integrated Survey of Travel and Activity. We estimated the average change in the cumulative travel characteristics associated with each additional trip to bars and liquor stores, accounting for complex trips to multiple destinations. Logistic regression models estimated odds that individuals travelled to outlets in relation to outlet density in their home local government area (LGA).ResultsAmong 23,512 respondents, 378 (1.6%) travelled to any bar and 79 (0.3%) any liquor store the survey day. Bar trips added 8.2 km (95% confidence interval [CI] 4.6, 11.8) and 18.1 min (95% CI 13.6, 22.6) to cumulative travel; 41% of attended bars were co‐located in participants' home LGA. Greater bar and liquor store density within the home LGA were associated with overall trips to these outlet types.Discussion and ConclusionsIndividuals travel beyond their residential area to bars, but travel to liquor stores closer to home. Bar and liquor store density within individuals' home LGA were associated with trips to outlets. Trips to local bars in near home comprised a minority of trips to bars in this sample. Studies of retail alcohol access should account for trips to bars away from home.
Understanding cultural values, norms and beliefs that may impact participation in genome‐editing related research: Perspectives of local communities in Botswana
Authors: Koloi‐Keaikitse Setlhomo , Kasule Mary , Kwape Irene , Jankie Dudu , Ralefala Dimpho , Ntseane Dolly Mogomotsi , Mokone Gaonyadiwe George 
Published: January 2024

AbstractGene‐editing research is a complex science and foreign in most communities including Botswana. Adopting a qualitative deliberative framework with 109 participants from 7 selected ethnic communities in Botswana, we explored the perceptions of local communities on cultural values, norms, and beliefs that may motivate or deter likely participation in the use of gene‐editing related research. What emerged as the ethnic community's motivators for research participation include the potential for gene‐editing technologies to promote access to individualized medications, and the possibility of protecting family members from genetic related diseases. Deterrents for research participation include cultural values such as implications of lineage for chieftainship, trust, fear or anxiety, uncertainty, and sensitivity on the use of gene‐editing. Findings of our study have implications for continuous engagement with local communities to explore potential ways of addressing cultural sensitivities that can further deter their participation in future gene‐editing related research.
Moderate realist ideology critique
Authors: Clark Rebecca L. 
Published: January 2024

AbstractRealist ideology critique (RIC) is a strand of political realism recently developed in response to concerns that realism is biased toward the status quo. RIC aims to debunk an individual's belief that a social institution is legitimate by revealing that the belief is caused by that very same institution. Despite its growing prominence, RIC has received little critical attention. In this article, I buck this trend. First, I improve on contemporary accounts of RIC by clarifying its status and the role of motivated reasoning. Second, I show that realist ideology critics face a dilemma: either their account makes deeply implausible epistemological assumptions, or they temper its epistemology at the expense of rendering it toothless. I argue for each horn in turn before revealing the dilemma to be a false one by making a novel distinction between varying strengths of RIC based on their underlying epistemological assumptions. I propose Moderate RIC as a solution: upon discovering that one reason for your belief that a social institution is legitimate is likely malignantly epistemically circular, the belief should undergo further epistemic testing. I respond to three potential objections and suggest that Moderate RIC would make a fruitful addition to political theorists' methodological toolkit.
Patients' perception of the benefits of palliative systemic therapy for advanced cancer
Authors: Subramaniam Shalini , Adams Diana H. , Tognela Annette , Roncolato Felicia , Yip Po Y. , Lim Stephanie H.‐S. , Roohullah Aflah , Stockler Martin R. , Kiely Belinda 
Published: January 2024

AbstractBackgroundPatients with advanced cancer who misunderstand their prognosis and chance of cure tend to overestimate the likely benefits of palliative systemic therapy.AimTo determine patient perceptions of palliative systemic therapy benefits in advanced cancer.MethodsWe surveyed 104 outpatients with advanced cancer receiving systemic anticancer therapy and their treating oncologists. Patients recorded their understanding of treatment impact on chance of cure and symptoms. Life expectancy was estimated by patients and oncologists. A visual analogue scale (0–10) was used to record how patients and oncologists valued quality of life (QOL) and length of life (LOL) (<4 QOL most important; 4–7 QOL and LOL equal; >7 LOL most important). Patient‐oncologist discordance was defined as a ≥4‐point difference.ResultsThe main reasons patients selected for receiving treatment were to live longer (54%) and cure their cancer (36%). Most patients reported treatment was very/somewhat likely to prolong life (84%) and improve symptoms (76%), whereas 20% reported treatment was very/somewhat likely to cure their cancer. 42% of patients selected a timeframe for life expectancy (choice of four timeframes between <1 year and ≥5 years); of these, 62% selected a longer timeframe than their oncologist. When making treatment decisions, 71% of patients (52% of oncologists) valued QOL and LOL equally. Patient‐oncologist discordance was 21%, mostly because of oncologists valuing QOL more than their patients (70%).ConclusionAt least 20% of patients receiving systemic therapy for advanced cancer reported an expectation of cure. Most patients and oncologists value QOL and LOL equally when making treatment decisions.
Characteristics of restricted selection indices and geometrical interpretation of restricted breeding values
Authors: Satoh Masahiro 
Published: January 2024

AbstractRestricted selection is used to control genetic changes in one or more characters. Three main selection indices are adopted for this purpose. First, Kempthorne's index is used to maximize aggregate breeding value (BV) with changes in some traits restricted to zero; second, Harville's index is used to maximize aggregate BV with proportional changes for some traits; and third, Yamada's index is mathematically used to achieve the relative desired changes for all traits. Kempthorne's index is equivalent to Harville's index. However, the relationship between Kempthorne's and Yamada's indices has not been clarified. In addition, the characteristics of restricted selection indices and the relationship between BV and restricted BV (RBV) are also unknown. The aim of this study was to clarify the characteristics of restricted selection indices and describe the relationship between BV and RBV by using linear algebra and geometric techniques, respectively. First, I proved that Yamada's index is part of Kempthorne's index. Second, I investigated the relationship between BVs that were estimated using an ordinary selection index (EBVs) and RBVs estimated using a restricted selection index (ERBVs) and proved that the ERBVs of the restricted traits are proportional to the relative desired changes. Third, I proved that RBV is represented by a linear function of BV and geometrically represented the relationship between BV and RBV. In this study, new findings on restricted selection indices and RBV were obtained. This useful clarification of the relationship between BV and RBV will make it possible to evaluate the response to selection using not only a restricted selection index, but also a restricted BLUP in computer simulation studies.
Caudal fluoroscopic guidance for the insertion of transvenous pacing leads
Authors: Morton Matthew B. , William Jeremy , Kistler Peter M. , Prabhu Sandeep , Sugumar Hariharan , Brink Olivier Van Den , Patel Hitesh , Mariani Justin , Voskoboinik Aleksandr 
Published: January 2024

AbstractBackgroundPneumothorax is a well‐recognized complication of cardiac implantable electronic device (CIED) insertion. While AP fluoroscopy alone is the most commonly imaging technique for subclavian or axillary access, caudal fluoroscopy (angle 40°) is routinely used at our institution. The caudal view provides additional separation of the first rib and clavicle and may reduce the risk of pneumothorax. We assessed outcomes at our institution of AP and caudal fluoroscopic guided pacing lead insertion.MethodsRetrospective cohort study of consecutive patients undergoing transvenous lead insertion for pacemakers, defibrillators, and cardiac resynchronization therapy devices between 2011 and 2023. Both de novo and lead replacement/upgrade procedures were included. Data were extracted from operative, radiology, and discharge reports. All patients underwent postprocedure chest radiography.ResultsThree thousand two hundred fifty‐two patients underwent insertion of pacing leads between February 2011 and March 2023. Mean age was 71.1 years (range 16–102) and 66.7% were male. Most (n = 2536; 78.0%) procedures used caudal guidance to obtain venous access, while 716 (22.0%) procedures used AP guidance alone. Pneumothoraxes occurred in five (0.2%) patients in the caudal group and five (0.7%) patients in the AP group (p = .03). Subclavian contrast venography was performed less frequently in the caudal group (26.2% vs. 42.7%, p < .01).ConclusionCaudal fluoroscopy for axillary/subclavian access is associated with a lower rate of pneumothorax and contrast venography compared with an AP approach.
Peter Abelard is not a Proto‐Kantian
Authors: Abadal Lily M. 
Published: January 2024

ABSTRACTThough there has been much debate about whether Abelard's ethics are dangerously subjective or surprisingly absolutist, one thing is unanimous: they are intentionalist. The goal of this article is to parse out what should be meant by this claim, distancing his ethical account from the popular Kantian appraisal. Though much of the secondary literature on Abelard likens him to Kant, I argue that this is mistaken. For Abelard, an agent's intentions are informed by their affections—whether carnal or spiritual. This becomes clear when contextualizing Abelard's use of intentio with a view to his Commentary on Romans. Using the account of intention I suggest—one nuanced by Abelard's own theological commitments and biblical exegesis—it will be clear that Abelard's ethics is not a case for the moral neutrality of the passions nor an ethic of pure reason.
Employee acceptance of digital transformation strategies: A paradox perspective
Authors: Klein Sascha P. , Spieth Patrick , Söllner Matthias 
Published: January 2024

AbstractDigital transformation (DT) strategies often aim at innovating an organization's business models (BMs) and developing digital innovations. However, most of the DT strategies fail or result only in incremental innovation. Research predominantly identified critical management capabilities for DT success, neglecting the role of employees, although employee support is vital for the successful implementation of DT strategies. We conceptualize employee acceptance of DT strategies and draw on paradox theory and organizational change literature to shed light on the antecedents of employee acceptance. Using survey‐based data from an incumbent introducing a DT strategy, we find empirical support that employees with a paradox mindset are likely to accept the DT strategy regardless of the expected scope of change, while a high scope of expected changes weakens the effect of a positive attitude toward change on acceptance. The findings contribute to understanding the micro‐level aspects of DT and extend research emphasizing top‐down management approaches in DT with an employee perspective. This study extends previous findings in innovation management that predominantly provide evidence on the acceptance of specific digital technologies and offer insights into the antecedents of DT strategy acceptance. We offer managers insights into how employees perceive DT strategies, which can help to leverage the potential of digital innovation.
Sleep disturbance correlated with severity of neuropathic pain in sciatic nerve crush injury model
Authors: Ho Anh , Lee Sung‐Jun , Drew Victor J. , Jung Jieun , Kang Jiseung , Cheong Chanyoung , Kim Tae 
Published: January 2024

SummaryThe association between sleep and pain has been investigated widely. However, inconsistent results from animal studies compared with human data show the need for a validated animal model in the sleep–pain association field. Our study aims to validate common neuropathic pain models as a tool for evaluating the sleep–pain association. Electrodes electroencephalogram (EEG) and electromyogram (EMG) were surgically implanted to measure sleep. The von Frey test was used to measure pain sensitivity. Following the baseline data acquisition, two pain‐modelling procedures were performed: sciatic nerve crush injury (SCI) and common peroneal nerve ligation (CPL). Post‐injury measurements were performed on days 1, 5, 10, and 15 post‐surgery. The results presented decreased paw withdrawal thresholds and reduced NREM sleep duration in both models on the first post‐surgery day. In the SCI model, NREM sleep duration was negatively correlated with paw withdrawal thresholds (p = 0.0466), but not in the CPL model. Wake alpha and theta EEG powers were also correlated with the pain threshold. The results confirm that the SCI model shows disturbed sleep patterns associated with increased pain sensitivity, suggesting it is a reliable tool for investigating sleep disturbances associated with neuropathic pain.
A multisensory approach to understanding bat responses to wind energy developments
Authors: Jonasson Kristin A. , Adams Amanda M. , Brokaw Alyson F. , Whitby Michael D. , O'Mara M. Teague , Frick Winifred F. 
Published: January 2024

Abstract

Millions of bats are killed at wind energy facilities worldwide, yet the behavioural mechanisms underlying why bats are vulnerable to wind turbines remain unclear. Anthropogenic stimuli that alter perceptions of the environment, known as sensory pollution, could create ecological traps and cause bat mortality at wind farms.

We review the sensory abilities of bats to evaluate potential stimuli associated with wind farms and examine the role of spatial scale on the perceptual mechanisms of sensory pollutants associated with wind energy facilities.

Audition, vision, somatosensation and olfaction are sensory modalities that bats use to perceive their environment, including wind farms and turbine structures, but they will not all be useful at the same spatial scales.

Bats most likely use vision to perceive wind farms on the landscape, and obstruction lighting may be the first sensory cue to attract bats to wind farms from kilometres away.

Research that assesses the risks posed by specific sensory pollutants, when conducted at the appropriate scale, can help identify solutions to reduce bat mortality, such as determining the attractiveness of obstruction lighting to bats at a landscape scale.
Modelling policies to improve affordability and consumption of nutritious foods for complementary feeding in Kenya
Authors: Traoré Fousseini , Omolo Miriam , Beal Ty , Nordhagen Stella , Codjia Patrick , Kiige Laura , Kamudoni Penjani , Arimi Caroline , Kirogo Veronica , Ortenzi Flaminia , Wouabe Eric Djimeu 
Published: January 2024

AbstractIn Kenya 26% of children under age 5 experience stunted growth, 4% are wasted and 11% are underweight. In pregnant women, the prevalence of iron deficiency is 36% and iron‐deficiency anaemia prevalence is 26%. Previous studies have identified affordability as a key barrier to the intake of nutrients, particularly from animal‐source foods (ASFs). Thus, this study analyzes to what extent the affordability of ASF in Kenya can be improved. It focuses on four ASFs: eggs, milk, chicken and beef. Using a computable general equilibrium model, three policy simulations were undertaken to establish the impact of potential changes on nutritious ASF availability and affordability: a 20% increase in total factor productivity (TFP) for the four products; a 20% TFP increase plus a 25% reduction in trade and transportation margins; and a 20% TFP increase for ASF and maize (a key input in animal feed). Simulations suggest increasing the productivity of the four ASF products would increase their availability and lower consumer prices (up to 17% lower). Household consumption of the four commodities would increase, resulting in improved household dietary diversity. Rural households would gain more compared with urban households. Poor households (the lowest 40%) would register larger welfare (Equivalent Variation) gains than other households in both urban and rural areas. The richest 20% of the population would neither lose nor gain following the policy changes. Reducing transportation costs and trade margins and increasing maize productivity could further reduce the price of ASFs through lower production costs and increased consumption.