bluuebunny/crossref_metadata_2025_split huggingface dataset:
Nasal Lining Repair: A Comprehensive Literature Review
Authors: Shah Kishan M. , Tate Jesalyn A. , Srivastava Divya , Nijhawan Rajiv I. 
Published: January 2024

BACKGROUND
Currently, there are limited reviews in the dermatology literature on how to approach reconstruction of nasal lining in full-thickness nasal defects resulting from Mohs micrographic surgery. Given variable training and experience, dermatologic surgeons may seek additional references to help reconstruct certain advanced defects. We sought to synthesize literature from dermatologic surgery, plastic surgery, and otolaryngology to review repair options and considerations for repair of nasal lining defects.

OBJECTIVE
To present a comprehensive literature review of repair options for nasal lining reconstruction and discuss advantages, disadvantages, specific anatomic considerations, and techniques to execute such options.

MATERIALS AND METHODS
Articles from several different reconstructive specialties including dermatologic/Mohs surgery, otolaryngology, and plastic and reconstructive surgery were reviewed. Instructive images were compiled to illustrate several techniques, with additional medical illustration recreations included to help showcase important reconstructive approaches.

RESULTS
A comprehensive descriptive review of nasal lining repair options for the reconstructive surgeon.

CONCLUSION
Advanced tumors can result in full-thickness nasal defects, and this review describes various reconstructive options for reconstruction based on the extent of the defect.
Intravitreal enzyme replacement for inherited retinal diseases
Authors: Rodriguez-Martinez Ana Catalina , Wawrzynski James , Henderson Robert H. 
Published: January 2024

Purpose of review
This paper provides an update on intravitreal (IVT) enzyme replacement therapy (ERT) in metabolic retinal diseases; particularly neuronal ceroid lipofuscinosis type 2 (CLN2) also known as Batten disease.

Recent findings
ERT is being explored in CLN2 related Batten disease, a fatal neurodegenerative condition associated with retinopathy and blindness that is caused by the deficiency of lysosomal enzyme TPP1. Cerliponase alfa, a recombinant human tripeptidyl-peptidase1 (rhTPP1) administered by intraventricular infusions has been demonstrated to slow the rate of neurodegenerative decline but not retinopathy. A preclinical study of IVT rhTPP1 in a CLN2 canine model demonstrated efficacy in preserving retinal function and retinal morphology shown on histology. More recently, intravitreal (IVT) administration of rhTPP1 was reported in a first-in-human compassionate use study. Patients received 12–18 months of 8-weekly IVT ERT (0.2 mg rhTPP-1 in 0.05 ml) in one eye. No significant ocular adverse reactions were reported. Treatment decreased the rate of retinal thinning but modestly.

Summary
The evidence suggests that IVT ERT with rhTPP1 may be a safe and effective treatment for CLN2 retinopathy. However, the optimal dosage and frequency to achieve the best possible outcomes requires further investigation as does patient selection.
Perceived Benefit of Active Over Passive Strategies for Pathophysiology Learning and Retention Among Physician Assistant Students
Authors: Murphy Michelle Pauley , Hung Woei 
Published: January 2024

Introduction
This study examines physician assistant (PA) student perceived benefit of active vs. passive studying strategies for learning and retaining physiology and pathophysiology content knowledge. Identifying beneficial studying strategies is crucial to building a strong content knowledge foundation to support PA students' clinical rotations.

Methods
Three cohorts of PA students (n = 64) were anonymously surveyed regarding perceived benefit of studying strategies for learning and retention of physiology and pathophysiology content knowledge. Students also ranked strategies from most to least beneficial.

Results
Strategies were identified during survey development pilot study as either active or passive. Physician assistant students rated the active strategies perceived benefit mean as significantly greater than the passive strategies mean for both the learning (t(61) = 9.24, P < .001, d = 1.38) and retention (t(58) = 8.19, P < .001, d = 1.21) conditions.

Discussion
This study provides evidence that PA students perceive active studying strategies to be more beneficial than passive strategies for acquiring physiology and pathophysiology content and retaining it into the clinical year.
Appendiceal actinomycosis mimicking malignant tumor: a rare case report
Authors: Khabyeh-Hasbani Nathan , Zino Sivan , Dima Elena , Avital Shmuel 
Published: January 2024

Introduction:
Actinomycosis is an uncommon bacterial infection caused by Actinomyces bacteria that typically progresses slowly and leads to the formation of masses. Although it commonly affects the cervicofacial area, about 20% of cases occur in the abdominopelvic region. Because the disease can be mistaken for a tumour due to its infiltrative mass-like nature on imaging, over 90% of cases are only diagnosed following surgery and histological confirmation. This report describes a case of an appendicular mass, initially suspected to be a malignant tumour, but eventually diagnosed as appendiceal actinomycosis.

Presentation of case:
Upon initial presentation, a 53-year-old woman with type II diabetes mellitus and no prior surgical history, displayed abnormal appendiceal uptake during a PET-computed tomography (CT) scan conducted for a suspected spinal tumour. Colonoscopy did not indicate any notable observations, and the patient chose to defer immediate action. Several months later, a CT scan revealed an increased mass-like appearance of the appendix compared to the previous PET-CT scan. After multidisciplinary discussions, a right laparoscopic hemicolectomy was recommended due to suspected malignancy. However, histological staining on microscopy confirmed actinomycosis originating from the appendix.

Discussion:
Chronic appendicitis with radiologic features similar to appendiceal carcinoma, or abdominal masses located in the ileocecal area, in patients with or without a previous surgical history should raise suspicion of actinomycosis.

Conclusion:
Appendiceal actinomycosis should be considered in the differential diagnosis in the aetiology of chronic appendicitis mimicking appendiceal carcinoma. Awareness and accurate diagnosis of appendiceal actinomycosis can prevent unnecessary extended surgery as was performed in this case.
Successful pregnancy after cyclophosphamide therapy for systemic lupus erythematosus: a case report
Authors: Drie Tasneem , Alsamman Mhd Imadaldin , Tarcha Raghad , Haidar Ghina , Kudsi Maysoun 
Published: January 2024

Introduction and importance:
The use of cyclophosphamide in women of childbearing age with severe systemic lupus erythematosus is normally indicated. However, cyclophosphamide is generally avoided during pregnancy due to the risk of teratogenicity, especially since its effect on fetal survival is poorly understood. This is a case report of a lupus patient exposed to cyclophosphamide during pregnancy.

Case presentation:
A 35-year-old woman with a history of lupus presented to our outpatient clinic in the 12th week of pregnancy for her sixth routine cyclophosphamide bolus. The fetal echocardiogram result with the gynecology consultation was normal with the recommendation for a medical termination of pregnancy, which has been refused by the patient. Shared decision-making with the patient included a discussion of the maternal risks of continuation of pregnancy in the setting of worsening systemic function and the fetal risks of definitive treatment with cyclophosphamide for a lupus flare and the patient decided to proceed with the pregnancy. Treatment with immunosuppressants, including azathioprine was initiated replacing cyclophosphamide with close monitoring of her and the fetus every month.

Clinical discussion:
The first trimester of pregnancy seems to be particularly susceptible to fetal malformations, although CPA effects on fetuses in later stages of pregnancy are also reported occasionally. Nonetheless, its repercussions on fetal survival remain poorly comprehended.

Conclusion:
In conclusion, exposing pregnancy to cyclophosphamide could end with pregnancy loss. Based on our experience, the survival of the fetus is strongly in doubt when cyclophosphamide is required to treat lupus in the mother. However, in rare cases, it could be without complications.
Hidden blood loss in three different endoscopic spinal procedures for lumbar disc herniation
Authors: Zhuang Haoxiang , Li Jiayi , Guo Sijia , An Ning , Fan Zihan , Tan Haining , Lin Jisheng , Su Nan , Yang Yong , Fei Qi , Meng Hai 
Published: January 2024

Purpose:
This study compared hidden blood loss (HBL) among three different endoscopic spinal procedures and investigated its risk factors.

Patients and methods:
This single-centre retrospective analysis collected data from consecutive hospitalized patients with single-segment lumbar disc herniation (LDH) undergoing unilateral biportal endoscopic discectomy (UBE), percutaneous endoscopic transforaminal discectomy (PETD), or percutaneous endoscopic interlaminar discectomy (PEID) from December 2020 to October 2022. HBL was calculated using Nadler’s and Gross’s formulas. The authors used Pearson’s or Spearman’s correlation analysis to explore the relationship between patient characteristics and HBL. Multivariate linear regression analysis was used to identify independent risk factors for HBL.

Results:
In total, 122 consecutive patients (68 females and 54 males) were enroled in this study. The average HBL was 381.87±218.01 ml in the UBE group, 252.05±118.44 ml in the PETD group and 229.63±143.9 ml in the PEID group (P<0.05). Pearson’s or Spearman’s correlation analysis showed that operative time, preoperative haemoglobin, preoperative haematocrit, and preoperative Albumin (ALB) were correlated with HBL in the UBE group, while sex, age, operative time, postoperative ALB, and patients’ blood volume (PBV) were related to HBL in the PETD group (P<0.05). Operative time and preoperative activated partial thromboplastin time were related to HBL in the PEID group (P<0.05). Multiple linear regression analysis showed a positive correlation between HBL and operative time in all three groups (P<0.001, P<0.001, P<0.05).

Conclusion:
HBL was higher in the UBE group than in the PETD and PEID groups, and operative time may be a common risk factor for the three groups.
Hydroxyurea for secondary stroke prevention in children with sickle cell anaemia: a systematic review of clinical evidence and outcomes
Authors: Aderinto Nicholas , Olatunji Gbolahan , Kokori Emmanuel , Abdulbasit Muili 
Published: January 2024

Background:
Stroke remains one of the leading complications of sickle cell anaemia (SCA) in children. Traditionally, SCA treatment focused on symptom relief. However, the high incidence of strokes in children has prompted a reevaluation of treatment, particularly hydroxyurea, for secondary stroke prevention. This study assesses hydroxyurea’s effectiveness and safety in preventing secondary strokes in paediatric SCA patients.

Methods:
This systematic review followed a pre-defined protocol registered with PROSPERO. Comprehensive searches were conducted across PubMed, Embase, Scopus, MEDLINE, Google Scholar, and the Cochrane Library up to August 2023. Studies were included involving paediatric SCA patients at risk of secondary stroke, assessing hydroxyurea as the primary intervention.

Results:
A total of six studies meeting inclusion criteria were included. The effectiveness of hydroxyurea in preventing secondary strokes, with variable responses reported across studies. Adverse effects, including mild neutropenia, are associated with hydroxyurea treatment but with variability in reported toxicity levels.

Conclusion:
Hydroxyurea holds promise in preventing recurrent strokes in children with SCA, though its efficacy and safety profiles vary among individuals. Optimal dosages and treatment durations require further investigation, necessitating vigilant monitoring of haematological parameters. Future research should refine dosing strategies, consider individual patient characteristics, assess long-term effects, and explore ancillary benefits beyond stroke prevention.
Bednar’s tumor at right shoulder in an adult male: a case report of a rare entity
Authors: Acharya Bimarsh , Yadav Dev K. , Chetry Ankita , Chhetri Pooja , Chhetri Priya , Shah Divyani 
Published: January 2024

Introduction and importance:
Bednar tumor, a rare variant of dermatofibrosarcoma protuberans is a tumor with low malignant potential. Owing to limited studies, the pathogenesis and risk factor of this tumor are not clearly understood. The tumor extends from the epidermis to the dermal layers and even affects the surrounding bone. Here, the authors present a case of a 48-year-old male with a Bednar tumor, which was successfully managed by wide local excision and flap repair.

Case presentation:
Our patient presented to the hospital after the reappearance of mass, 6 years after the excision of the previously misdiagnosed lipoma. Vitals and systematic examination were normal. Local examination revealed an oval-shaped mass with a glistening surface on the right shoulder. The patient underwent wide excision and skin flap surgery for the treatment, and the diagnosis was confirmed through histopathological examination and immunohistochemistry for the CD34 marker.

Clinical discussion:
Bednar tumor is an infrequent skin tumor linked to genetic anomalies and is one of the rare variants [(<0.1%) of skin tumors]. Diagnosis can be done by histopathological examination and CD34 marker positivity via immunohistochemistry. This tumor is mistaken for lipoma, leading to recurrent growth postexcision. The tumor demands a broader resection due to the high chances of reoccurrence. Although Mohs micrographic surgery is the ideal approach, its limited availability in resource-constrained settings prompts alternative strategies.

Conclusion:
This case highlights the challenges of diagnosis, the rarity of the condition, and the need for vigilant follow-up due to the tumor’s propensity for recurrence.
Stability of Ocular Alignment After Teprotumumab Therapy in a Cohort of Patients With Thyroid Eye Disease and Baseline Diplopia
Authors: Davis James B. , Mudalegundi Shwetha , Henderson Amanda D. , Carey Andrew R. 
Published: January 2024

Background:
Teprotumumab is a monoclonal antibody that is effective in treating patients with thyroid eye disease (TED) and has been shown to produce subjective improvements in diplopia in this group. The aims of this study were to evaluate the rate and timing of recurrence/worsening of diplopia after teprotumumab treatment in a cohort of patients with TED presenting with diplopia at baseline.

Methods:
A retrospective chart review of 15 patients with diplopia secondary to TED, treated with teprotumumab, was conducted in a single-center academic institution. The primary outcome was the rate of recurrence/worsening of diplopia after completing teprotumumab. Secondary outcomes include the time to recurrence/worsening of diplopia and clinical activity scores (CAS) to correlate with changes in ocular alignment.

Results:
Fifteen patients met the inclusion criteria for this study, and 7 of these had recurrence of diplopia (46.7%). Two patients had worsening of CAS to ≥4, 6 had worsening of CAS to 3, and the other 7 had CAS ≤2 during the follow-up period. The mean follow-up period was 20.4 months (SD 7.2) after completing teprotumumab. The mean time to diplopia recurrence/worsening was 8.8 months (range 6.7–12.2, SD 1.8).

Conclusions:
Patients with TED and baseline diplopia have a substantial rate of recurrence/worsening of diplopia after teprotumumab therapy, suggesting that they may not have stable ocular alignment immediately after treatment. Strabismus surgeons may need to weigh the significant risk of disease relapse when planning optimum timing for surgical correction.
Hearables: feasibility of recording cardiac rhythms from single in-ear locations
Authors: Yarici Metin , Von Rosenberg Wilhelm , Hammour Ghena , Davies Harry , Amadori Pierluigi , Ling Nico , Demiris Yiannis , Mandic Danilo P. 
Published: January 2024

The ear is well positioned to accommodate both brain and vital signs monitoring, via so-called hearable devices. Consequently, ear-based electroencephalography has recently garnered great interest. However, despite the considerable potential of hearable based cardiac monitoring, the biophysics and characteristic cardiac rhythm of ear-based electrocardiography (ECG) are not yet well understood. To this end, we map the cardiac potential on the ear through volume conductor modelling and measurements on multiple subjects. In addition, in order to demonstrate real-world feasibility of in-ear ECG, measurements are conducted throughout a long-time simulated driving task. As a means of evaluation, the correspondence between the cardiac rhythms obtained via the ear-based and standard Lead I measurements, with respect to the shape and timing of the cardiac rhythm, is verified through three measures of similarity: the Pearson correlation, and measures of amplitude and timing deviations. A high correspondence between the cardiac rhythms obtained via the ear-based and Lead I measurements is rigorously confirmed through agreement between simulation and measurement, while the real-world feasibility was conclusively demonstrated through efficacious cardiac rhythm monitoring during prolonged driving. This work opens new avenues for seamless, hearable-based cardiac monitoring that extends beyond heart rate detection to offer cardiac rhythm examination in the community.
Atypical presentation of varicella-zoster virus reactivation in a lung transplant patient: a case report
Authors: Hoff Ingrid , Rath Eivind , Pena-Karan Slobodanka , Sivy Nginamau Elisabeth , Holm Are Martin , Thune Turid , Mustafa Tehmina 
Published: January 2024

Background: Varicella zoster virus (VZV) is a human neurotropic virus which commonly causes infection during childhood. Later in life it may reactivate as herpes zoster. We report a rare manifestation of reactivation of VZV infection presenting as cutaneous vasculitis and varicella pneumonia in a lung transplant recipient.
Case presentation: A 65 year old man was lung transplanted bilaterally for emphysema. Nine months post-transplant he presented with dyspnea and a cutaneous vasculitis-like eruption. VZV reactivation was not suspected due to absence of the typical vesicular eruptions. The diagnosis was confirmed by VZV PCR from the swabs of the ulcer after skin punch biopsy of a lesion and from bronchoalveolar lavage (BAL). The histology of skin biopsy demonstrated epithelial and vascular damage but no typical epithelial virus associated changes. The patient responded to antiviral therapy with total remission of rash and VZV DNA was not detectable from repeated BAL after 29 days of therapy. However, the pulmonary radiological features and dyspnea persisted due to reasons possibly unrelated to the VZV infection.
Conclusion: Had it not been for the patient to mention the resemblance of the vasculitic rash with his primary VZV infection, the diagnosis would easily have been overlooked. In this case, the biopsy did not show typical histopathologic findings of VZV-vasculitis. What led the diagnosis was PCR from the wound swab taken after punch biopsy. This case serves as a reminder for atypical presentation of common conditions in immunosuppressed patients and that extensive diagnostic sampling may be warranted in this group.
Unraveling consumer behavioral intentions to adopt solar water heaters in India using UTAUT model
Authors: Kaur Prabhjot , Ritu Rajveer Kaur , Kaur Amanpreet 
Published: January 2024

PurposeThe present study identifies the factors that impact behavioral intentions to adopt solar water heaters (SWHs) and examines their relationship with behavioral intentions using an extended “Unified Theory of Acceptance and Use of Technology” (UTAUT) model.Design/methodology/approachThe study used a primary survey to collect data from 423 respondents across seven Indian states selected through purposive sampling. The collected data was analyzed using IBM SPSS software and “Structural Equation Modeling” (SEM) was performed using SmartPLS 3.5.5.FindingsThe results suggest that social influence is the most significant factor affecting SWH adoption, followed by effort, performance expectancy and facilitating conditions. The perceived cost negatively affects behavioral intentions and social influence on behavioral intentions is partially mediated by facilitating conditions. People prefer SWHs if they are easy to install and compatible with other home appliances. Positive perception of friends and family, easy access and government incentives contribute to SWH adoption.Practical implicationsSWH adoption can be promoted by designing sector-specific programs and improving ease of installation, operation, maintenance and after-sale services.Originality/valueThis study explores the behavioral intentions of individuals in India to adopt SWHs. India is a developing tropical country with a high potential for SWH adoption but has not received much attention. Further, the research integrates the perceived cost construct in the UTAUT model and examines the partial mediation impact of facilitating conditions to improve the model’s comprehensibility.
Measuring the growth and impact of library and information science research in India: a multidimensional scientometric assessment
Authors: Muzamil Mushtaq Muzamil Mushtaq , Malik Basharat Ahmad , Khan Nida 
Published: January 2024

Purpose
This study aims to provide insight into Library and Information Science (LIS) research in India using scientometric approaches. Web of Science (WoS) and SCOPUS databases were used for data retrieval. The study examines productivity in terms of source types, gender distribution, document formats, authorship and other factors. In addition, this study sought to identify trends or patterns in the research preferences of LIS scientists through text analysis.

Design/methodology/approach
Data were downloaded from the WoS and Scopus databases over 22 years and analysed using VOSviewer, Orange, Biblioshiny and CRExplorer softwares.

Findings
The findings reveal that 5,692 out of the 9,384 documents in both databases underwent the final examination. In total, 466 different sources produced all of those papers. Author analysis revealed that 6,603 different authors authored 5,692 documents. There were 4,209 male and 1,063 female authors. Furthermore, India shares maximum collaborations with the USA and England. The spectrogram features nine significant peaks corresponding to Lotka’s, Bradford’s and similar laws. Text analysis revealed that Indian LIS researchers have consistently investigated open access and digital or open libraries.

Research limitations/implications
The findings of this study will provide readers with a better understanding of India’s contribution to LIS. In addition, the study will help academics identify research gaps and undiscovered areas in the Indian context that require further investigation.

Originality/value
Not many studies highlight Indian research trends and international collaboration in LIS. This study highlights research trends, collaboration and gender productivity in LIS. The most cited references and trending topics were also identified using reference publication year spectroscopy and text analysis techniques.