bluuebunny/crossref_metadata_2025_split huggingface dataset:
Manifestações clínicas da beta talassemia maior na população pediátrica: Uma revisão sistemática
Authors: Silva Nathália Ribeiro , Queiroz Rebecca Castro , Menezes Neto Antonio Gonzaga de , Costa Juliana Maria Batista , Rodrigues Ilka Juliana Ferreira 
Published: December 2023

O trabalho objetivou investigar informações na literatura a respeito das manifestações clínicas associadas a beta talassemia maior (BTM) em pacientes pediátricos. Para tanto, foi realizada uma revisão sistemática da literatura seguindo as diretrizes do Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA). Foram utilizados os descritores “beta talassemia”, “sinais e sintomas” e “criança”, nas plataformas de busca PubMed, Scielo, Science Direct, Science.gov e LILACS, para busca de artigos publicados entre 2013 e 2023. Após avaliação das bases de dados, foram selecionados 12 artigos para composição deste trabalho. Todos os artigos foram publicados na língua inglesa e a maioria deles (n=7) teve como país de origem o Egito. Quanto a natureza dos estudos observou-se que a maioria deles eram do tipo transversal (n=7), seguidos de estudos do tipo caso-controle (n=4) e apenas um do tipo coorte. Os artigos descreveram a identificação de manifestações clínicas em pacientes pedriáticos portadores de BTM e a importância de sua identificação. Foi reportado que dislipidemias (alterações de HDL-colesterol, LDL-colesterol e triglicerídios) estão relacionadas com alterações cardiovasculares em portadores de BTM. Aumento de fator de crescimento endotelial vascular esteve associado a desenvolvimento de hipertensão pulmonar. A deposição excessiva de ferro foi associada a disfunções ventriculares, aterosclerose, afecções renais e pancreáticas. Osteopenia associada a alterações hormonais da paratireoide também foram reportadas na BTM. Assim, conclui-se que a BTM é a doença sanguínea hereditária autossômica mais comum na população e que suas manifestações clínicas geram impacto negativo na qualidade de vida relacionada à saúde de pacientes pediátricos.
Numerical simulation of hydraulic fracture propagation under energy supplement conditions
Authors: Dong Jingfeng , Qu Hongyan , Zhang Jingchun , Han Feipeng , Zhou Fujian , Shi Peize , Shi Jilong , Yu Tianxi 
Published: December 2023

After the long-term production, due to the influence of low-pressure and low-stress fields in the near-well area, the reversion and propagation of new fractures after temporary plugging is short. It is difficult for the new fracture to extend to the remaining oil enrichment areas on both sides of the primary fractures, resulting in a low increase in the bandwidth of the fracture group after repeated fracturing, which affects the reservoir utilization. In the early stage of repeated fracturing, a large amount of pre-fracturing fluid is injected to supplement the energy of the fractures and rapidly increase the pore pressure in the local range, weakening rock strength and change the pore structure. In addition, the combination of energy replenishment and reservoir stimulation, coupled reconstruction of the seepage field and stress field, promotes the effective propagation of new fractures. However, in the process of increasing formation energy, the propagation law of hydraulic fractures and natural fractures is not clear. In this paper, the model of tight sandstone reservoir in the HQ block of Ordos Basin was established with the finite element software ABAQUS, based on the effective stress principle and the theoretical method of fluid-solid coupling numerical simulation. The propagation of a single hydraulic fracture and the interaction between hydraulic fracture and natural fracture under the condition of energy increase was investigated to better guide the field operation. The results show that for every 1 MPa pressure increase in a single hydraulic fracture, the fracture length increases by 0.62 m and the maximum fracture width decreases by 0.09 mm. When the formation energy increases by 6 MPa, the time for the hydraulic fracture to reach the intersection point with the natural fracture is shortened by 10 %, and the length of the natural fracture is 2.16 times compared with the case of 3 MPa energy increase.
Analysis of overburden movement and side abutment pressure distribution in deep stope with varying coal seam thickness
Authors: Yang Yongjie , Meng Lingren , Yuan Lei 
Published: December 2023

To investigate the overburden movement and the side abutment pressure distribution concerning the variation in deep mines with varying coal seam thickness, this study focused on the No. 72 mining area of Tianchen Coal Mine and obtained the following results: Variations in coal seam thickness within a stope lead to increased immediate roof thickness. When the coal seam thickness is 8 m, the maximum immediate roof thickness reaches 18 m. The roof is composed of a “Combined short cantilever-Voussoir beam” structure. Displacement curves of overburden in coal seam thickness-varying stopes exhibit asymmetry, with the overburden closer to the coal seam being more asymmetric. After post-goaf stabilization, the peak side abutment pressure decreases with increasing coal seam thickness and shifts deeper into the coal wall. Concurrently, the ultimate equilibrium area width expands. With an increase in coal seam thickness from 4 m to 8 m, the peak side abutment pressures decreased from 44.98 MPa to 41.04 MPa. The peak position shifted from a distance of 9 m from the coal wall to 14 m, while the stress-relaxation area expanded from 3 m to 5 m. This research provides essential insights for safe and efficient mining in similar conditions.
Mineral solubilizing microorganisms and their combination with plants enhance slope stability by regulating soil aggregate structure
Authors: Wang Lingjian , Tang Xinggang , Liu Xin , Xue Rengui , Zhang Jinchi 
Published: December 2023

IntroductionThe stability of exposed slopes is prone to natural disasters, seriously threatening socio-economic and human security. Through years of exploration and research, we proposed an active permanent greening (APG) method based on patented mineral solubilizing microorganisms (MSMs) as an improvement over the traditional greening method.MethodsIn this study, we selected two MSMs (Bacillus thuringiensis and Gongronella butleri) and a plant species (Lolium perenne L.) set up six treatments (T1, T2, T3, T4, T5, and T6) to investigate the effectiveness of the MSMs and their combinations with the plant species on the soil stability using APG method.ResultsWe noted that both MSMs and the plant species significantly improved soil aggregate stability and organic matter content. Of all the treatments, the T1 treatment exhibited better results, with soil aggregate stability and organic matter content increased to 45.63% and 137.57%, respectively, compared to the control. Soil stability was significant positively correlated with macroaggregate content and negatively with microaggregates. Using structural equation modeling analysis, we further evaluated the mechanism underpinning the influence of organic matter content and fractions on the content of each graded agglomerates. The analysis showed that the macroaggregate content was influenced by the presence of the plant species, primarily realized by altering the content of organic matter and aromatic and amide compounds in the agglomerates, whereas the microaggregate content was influenced by the addition of MSMs, primarily realized by the content of organic matter and polysaccharide compounds. Overall, we observed that the effect of the co-action of MSMs and the plant species was significantly better than that of using MSMs or the plant species alone.DiscussionThe findings of this study provide reliable data and theoretical support for the development and practical application of the APG method to gradually develop and improve the new greening approach.
Magnesium supplementation beneficially affects depression in adults with depressive disorder: a systematic review and meta-analysis of randomized clinical trials
Authors: Moabedi Mahdi , Aliakbari Mohammadreza , Erfanian Shima , Milajerdi Alireza 
Published: December 2023

BackgroundThe findings from randomized clinical trials (RCTs) examining the effect of magnesium supplementation on depression are inconsistent. We decided to conduct a meta-analysis that summarizes all the evidence on the impact of magnesium supplementation on depression scores in adults with depressive disorder.MethodsWe conducted a systematic search in the online databases using all related keywords up to July 2023. We included all randomized clinical trials examining the effect of magnesium, in contrast to placebo, on depression scores.ResultsFinally, seven clinical trials were included in this systematic review, building up a total sample size of 325 individuals with ages ranging from 20 to 60 years on average. These RCTs resulted in eight effect sizes. Our findings from the meta-analysis showed a significant decline in depression scores due to intervention with magnesium supplements [standardized mean difference (SMD): −0.919, 95% CI: −1.443 to −0.396, p = 0.001].ConclusionOur review suggests that magnesium supplementation can have a beneficial effect on depression. Future high-quality RCTs with larger sample sizes must be run to interpret this effect of magnesium on depression in clinical settings.Systematic review registrationhttps://www.crd.york.ac.uk/prospero/display_record.php?RecordID=447909.
Primary Graft Function and 5 Year Insulin Independence After Pancreas and Islet Transplantation for Type 1 Diabetes: A Retrospective Parallel Cohort Study
Authors: Chetboun Mikael , Masset Christophe , Maanaoui Mehdi , Defrance Frédérique , Gmyr Valéry , Raverdy Violeta , Hubert Thomas , Bonner Caroline , Supiot Lisa , Kerleau Clarisse , Blancho Gilles , Branchereau Julien , Karam Georges , Chelghaf Ismaël , Houzet Aurélie , Giral Magali , Garandeau Claire , Dantal Jacques , Le Mapihan Kristell , Jannin Arnaud , Hazzan Marc , Caiazzo Robert , Kerr-Conte Julie , Vantyghem Marie-Christine , Cantarovich Diego , Pattou François 
Published: December 2023

In islet transplantation (ITx), primary graft function (PGF) or beta cell function measured early after last infusion is closely associated with long term clinical outcomes. We investigated the association between PGF and 5 year insulin independence rate in ITx and pancreas transplantation (PTx) recipients. This retrospective multicenter study included type 1 diabetes patients who underwent ITx in Lille and PTx in Nantes from 2000 to 2022. PGF was assessed using the validated Beta2-score and compared to normoglycemic control subjects. Subsequently, the 5 year insulin independence rates, as predicted by a validated PGF-based model, were compared to the actual rates observed in ITx and PTx patients. The study enrolled 39 ITx (23 ITA, 16 IAK), 209 PTx recipients (23 PTA, 14 PAK, 172 SPK), and 56 normoglycemic controls. Mean[SD] PGF was lower after ITx (ITA 22.3[5.2], IAK 24.8[6.4], than after PTx (PTA 38.9[15.3], PAK 36.8[9.0], SPK 38.7[10.5]), and lower than mean beta-cell function measured in normoglycemic control: 36.6[4.3]. The insulin independence rates observed at 5 years after PTA and PAK aligned with PGF predictions, and was higher after SPK. Our results indicate a similar relation between PGF and 5 year insulin independence in ITx and solitary PTx, shedding new light on long-term transplantation outcomes.
Phenolic Compounds and Antioxidant Properties of Fermented Beetroot Juices Enriched with Different Additives
Authors: Jakubczyk Karolina , Melkis Klaudia , Janda-Milczarek Katarzyna , Skonieczna-Żydecka Karolina 
Published: December 2023

Fermented beetroot juice is a beverage obtained from the fermentation of beetroot, most commonly red beet (Beta vulgaris L. var. conditiva). Nowadays, this product is increasingly recognised as a functional food with potentially beneficial health properties. It has been suggested to have antioxidant, anti-inflammatory, anticancer, antihypertensive, immunomodulatory, and probiotic effects, among others. Moreover, with the increasing popularity of the drink, newer variants are appearing in the food market, obtained by modifying the traditional recipe, adding other raw materials, herbs, and spices. Therefore, the aim of this study was to evaluate and compare the antioxidant potential and phytochemical composition of the selected fermented beetroot juices in different flavour variants available in the Polish food market. The study material consisted of six fermented beetroot juices: traditional, with garlic, with horseradish, with acerola, without salt, and iodized. The obtained results showed that the addition of acerola, horseradish, garlic, salt, and iodine in the form of sodium iodide and potassium iodide influenced the composition and properties of fermented beetroot juice. The most promising product in terms of potentially beneficial health properties related to the prevention of free radical diseases was fermented beetroot juice without salt (FRAP—5663.40 µM Fe (II)/L, ABTS—96.613%, TPC—760.020 mg GAE/L, TFC—221.280 mg RE/L). Iodized fermented beetroot juice had the highest vitamin C content—51.859 mg/100 mL. However, all the products tested were characterised by a significant content of biologically active substances with antioxidant properties and showed a high antioxidant potential. Moreover, all the fermented beetroot juices were rated positively in terms of flavour intensity, sweetness, acidity, colour, and overall acceptability. They can, therefore, be a good source of antioxidants in the daily diet.
ANALISIS D-DIMER DAN CRP PADA PASIEN COVID-19 DENGAN KOMORBID DIABETES MELLITUS
Authors: Daulay Warida , Anhar Citra Amaniah , Purnama Adik 
Published: December 2023

Severe Acute Respiratory Syndrome Coronavirus 2 (SARS CoV-2) is a virus that attacks and causes respiratory problems with general symptoms of fever accompanied by a dry cough, shortness of breath, and in severe cases. Patient with comorbid diabetes mellitus are in the high-risk category if they get infected with Covid-19, with a 50% risk of death compared to those without diabetes mellitus. In Covid-19 patients, coagulation disorders are often found, and to assess the continuity of the coagulation process, a D-Dimer examination is carried out. Disturbances in coagulation are often associated with inflammatory processes in patients with Covid-19, and to find out, CRP levels are checked. This study aims to determine the relationship between D-dimer and CRP levels in confirmed Covid-19 patients with comorbid diabetes mellitus at the Jakarta Hajj Hospital. The research was conducted in June 2022 with a cross-sectional research design. Data was taken from medical records of patients aged over 25 years who were treated with confirmed Covid-19 with comorbid diabetes mellitus at the Jakarta Hajj Hospital for the period June 2021-September 2021 and obtained data for 80 people. Analysis of D-Dimer levels in this study with confirmed Covid-19 patients with comorbid Diabetes Mellitus were high (0.5 ng/mL) in 50 people (63%) and normal (â‰¤0.5 ng/dL) in 30 people (37%). Meanwhile, on CRP levels, the analysis found that 55 people (69%) were high ( 60 mg/dL), and 25 people (31%) were normal (â‰¤60 mg/dl).Â Keywords: C-Reaktif Protein, COVID-19, D-Dimer, Diabetes Mellitus Comorbid
NITROGEN USE EFFICIENCY IN SUNFLOWER (HELIANTHUS ANNUUS L.) INFLUENCED BY VARIOUS FERTIGATION AND BED PLANTING TECHNIQUES
Authors: Khaliq Abdul , Zafar Muhammad , Sajjad Muhammad , Hassan Mahmood-Ul , Mudassar Muhammad Akhlaq , Shakoor Muhammad Abdul , Yasin Mubashra , Niaz Salma 
Published: December 2023

Low nitrogen fertilizer use efficiency and high losses of nitrogen are the critical challenges being faced by sunflower grower. To address these concerns, an experiment was carried out during spring 2021 at the Agronomic research area of the Agriculture University, Faisalabad. The randomized complete block design experiment was used with three replications under split plot arrangement. The 5m x 3m net plot size was kept with sowing procedures retained in the main plot and nitrogen application techniques kept in the sub plot. The experiment was planted on 20-02-2021. The matured crop was reaped on 18 June, 2021 manually. The single row hand drill was used to sow sunflower crop. The 75 cm line to line and 25 cm plant to plant distance was maintained. The results indicated that plant population ranged from 73 to 74 with maximum plant height of 174.33 cm, stem diameter (3.70 cm), head diameter (23.13 cm), number of achenes per head (1237.6), 1000-achene weight (68.17 g), highest biological yield (10.92 t ha-1), achene yield (3.22 t ha-1), harvest index (29.48 %) and protein contents (29.03 %) was observed in treatment where nitrogen was applied by fertigation method and sunflower was sown on beds. But maximum oil contents (41.78 %) were observed where nitrogen was side dressed and flat sowing technique was adopted for crop sowing. It is found that use of fertigation method of nitrogen application and bed planting techniques proved to be the best combination for improving growth, yield & yield relating attributes and improve fertilizer use efficiency with lower nitrogen losses for sunflower (Hybrid-33) under agro-climatic conditions of Faisalabad.
INTERNAL CONTROL AND BUSINESS SUSTAINABILITY OF ANTI-RIBA COMMUNITY
Authors: Muhammad Raihan Alfathi  , Sugiyarti Fatma  Laela  
Published: December 2023

This study aims to analyze the internal control practices of the Anti-Riba Community in the Sharia property business. This study applies a case study method using PT Azzura Griya Utama, a Shariah property business, as the research object. Data were collected using in-depth interviews with the company’s CEO and described qualitatively. The findings show that the internal control components, to some extent, have been implemented in the company. As a high-risk potential business, because it does not involve banks in their transactions with customers, it appears to need mechanisms and procedures to mitigate risks if customer problems occur. The company relies on control that is more personal and cultural by strengthening education on Sharia values. Other components of internal control continue to be improved as the company realizes the business is growing.

Abstrak
Penelitian ini bertujuan untuk menganalisis praktik pengendalian internal pada Komunitas Anti Riba dalam bisnis properti syariah. Penelitian ini menggunakan metode studi kasus dengan objek penelitian PT Azzura Griya Utama yang bergerak di bidang properti syariah. Pengumpulan data dilakukan dengan wawancara mendalam dengan CEO perusahaan dan dideskripsikan secara kualitatif. Temuan menunjukkan bahwa komponen pengendalian internal sampai batas tertentu telah diterapkan di perusahaan. Sebagai bisnis yang memiliki potensi risiko tinggi karena tidak melibatkan bank dalam transaksinya dengan nasabah, namun perusahaan tampaknya belum memiliki mekanisme dan prosedur untuk memitigasi risiko jika terjadi masalah dengan nasabah. Perusahaan mengandalkan pengendalian yang lebih personal dan kultural dengan memperkuat edukasi nilai-nilai syariah. Komponen pengendalian internal lainnya terus ditingkatkan seiring dengan semakin berkembangnya perusahaan.
AKUNTANSI KESALINGAN: REKONSTRUKSI AKUNTANSI RUMAH TANGGA PERSPEKTIF MUBADALAH
Authors: Sholihah Ria Anisatus , Nurani Shinta , Mubarok Muhammad Sultan 
Published: December 2023

This article aims to reconstruct household accounting from a mubadalah perspective. This article uses literature research through mubadalah analysis initiated by Faqihuddin Abdul Kodir to reconstruct the concept of household accounting which is perceived more as a private area and is attached to feminine characteristics so that household accounting is associated with the prospect of mutuality (mubadalah). The main finding is the mutual relationship between husband and wife that is needed in implementing household accounting practices with the stages: (1) commitment; (2) budgeting; (3) recording; (4) decision making; and (5) long-term financial planning. This study has implications for the use of the philosophical foundation of horizontal social monotheism in economic activities, especially household accounting practices.
Abstrak
Artikel ini bertujuan untuk merekonstruksi akuntansi rumah tangga dari perspektif mubadalah. Artikel ini menggunakan riset kepustakaan melalui analisis mubadalah yang digagas Faqihuddin Abdul Kodir untuk merekonstruksi konsep akuntansi rumah tangga yang lebih dipersepsikan sebagai wilayah privat dan lekat dengan karakteristik feminim sehingga akuntansi rumah tangga dikaitkan perspektif kesalingan (mubadalah). Temuan Utama adalah relasi kesalingan antara suami istri diperlukan dalam melaksanakan praktik akuntansi rumah tangga dengan tahapan: (1) penetapan komitmen; (2) penganggaran; (3) pencatatan; (4) pengambilan keputusan; dan (5) perencanaan keuangan jangka Panjang. Kajian ini berimplikasi pada penggunaan landasan filosofis tauhid sosial horizontal dalam aktivitas ekonomi terutama praktik akuntansi rumah tangga.
PENGEMBANGAN MEDIA BIMBINGAN BERBASIS WEBSITE UNTUK MENINGKATKAN KESEHATAN MENTAL PADA MAHASISWA PROGRAM STUDI PASTORAL KONSELING IAKN TORAJA
Authors: Gala Fernita Sari , Sinring Abdullah , Anas Muhammad 
Published: December 2023

This study aims to develop a website-based advice medium prototype to educate students, particularly those enrolled in the Pastoral Counseling Study Program at IAKN Toraja, on mental health. To address the research objectives, the researchers employed the Research and Development methodology outlined by Borg and Gall, adapted to suit the specific requirements of the product under development. Researchers initiated the study by commencing a requirement assessment, followed by executing data collecting, formulating an initial product design, validating the design through expert testing, revising the plan based on feedback, running a limited trial, and then revising the product. The website bestieku.org was developed and evaluated by professionals in the field. The assessments received from these experts varied. Specifically, BK experts provided highly positive evaluations, with a percentage of 91.07%. Reviews from media and education experts were generally positive, with a rate of 75%. In the interim, the practical examination administered to counseling practitioners yielded a commendable qualification, attaining a percentage of 79.16%. Based on a small-scale exam conducted on a cohort of 20 students, a notable level of proficiency was achieved, as evidenced by an 85% success rate. Based on the findings, implementing a website-based guidance media prototype holds significant potential in enhancing the mental well-being of students.
Tujuan penelitian ini ialah menghasilkan prototipe media bimbingan berbasis website untuk mengedukasi mahasiswa tentang kesehatan mental, khususnya pada mahasiswa Program Studi Pastoral Konseling IAKN Toraja. Untuk menjawab tujuan penelitian, maka peneliti menggunakan metode Research and Development (R & D) dari Borg dan Gall yang telah dimodifikasi sesuai dengan produk yang sedang dikembangkan. Peneliti memulai penelitian dengan melaksanakan need assessment (analisis kebutuhan), selanjutnya melaksanakan pengumpulan data, rancangan produk awal, validasi desain (uji ahli), revisi desain, uji coba terbatas dan revisi produk. Produk yang dihasilkan ialah website bestieku.org dan dari validasi para ahli diperoleh penilaian yang cukup beragam yakni ahli BK memberi kualifikasi sangat baik dengan persentase 91,07%, ahli media dan pendidikan memberi penilaian baik dengan persentase 75%. Sedangkan pada uji praktisan dari praktisi BK diperoleh kualifikasi praktis dengan persentase 79,16%, sedangkan dari 20 orang mahasiswa yang diuji pada kelompok kecil, diperoleh kualifikasi sangat baik dengan persentase 85 %. Jadi dapat disimpulkan prototipe yang dikembangkan berupa media bimbingan berbasis website untuk meningkatkan kesehatan mental pada mahasiswa sangat praktis dan sangat layak untuk digunakan.