bluuebunny/crossref_metadata_2025_split huggingface dataset:
On the Connection Between Language Change and Language Processing
Authors: Hendrix Peter , Sun Ching Chu , Brighton Henry , Bender Andreas 
Published: December 2023

AbstractPrevious studies provided evidence for a connection between language processing and language change. We add to these studies with an exploration of the influence of lexical‐distributional properties of words in orthographic space, semantic space, and the mapping between orthographic and semantic space on the probability of lexical extinction. Through a binomial linear regression analysis, we investigated the probability of lexical extinction by the first decade of the twenty‐first century (2000s) for words that existed in the first decade of the nineteenth‐century (1800s) in eight data sets for five languages: English, French, German, Italian, and Spanish. The binomial linear regression analysis revealed that words that are more similar in form to other words are less likely to disappear from a language. By contrast, words that are more similar in meaning to other words are more likely to become extinct. In addition, a more consistent mapping between form and meaning protects a word from lexical extinction. A nonlinear time‐to‐event analysis furthermore revealed that the position of a word in orthographic and semantic space continues to influence the probability of it disappearing from a language for at least 200 years. Effects of the lexical‐distributional properties of words under investigation here have been reported in the language processing literature as well. The results reported here, therefore, fit well with a usage‐based approach to language change, which holds that language change is at least to some extent connected to cognitive mechanisms in the human brain.
Maribavir: Mechanism of action, clinical, and translational science
Authors: Sun Kefeng , Fournier Martha , Sundberg Aimee K. , Song Ivy H. 
Published: December 2023

AbstractMaribavir is an oral benzimidazole riboside for treatment of post‐transplant cytomegalovirus (CMV) infection/disease that is refractory to prior antiviral treatment (with or without resistance). Through competitive inhibition of adenosine triphosphate, maribavir prevents the phosphorylation actions of UL97 to inhibit CMV DNA replication, encapsidation, and nuclear egress. Maribavir is active against CMV strains with viral DNA polymerase mutations that confer resistance to other CMV antivirals. After oral administration, maribavir is rapidly and highly absorbed (fraction absorbed >90%). The approved dose of 400 mg twice daily (b.i.d.) achieves a steady‐state area under the curve per dosing interval of 128 h*μg/mL and trough concentration of 4.90 μg/mL (13.0 μM). Maribavir is highly bound to human plasma proteins (98%) with a small apparent volume of distribution of 27.3 L. Maribavir is primarily cleared by hepatic CYP3A4 metabolism; its major metabolite, VP44669 (pharmacologically inactive), is excreted in the urine and feces. There is no clinically relevant impact on maribavir pharmacokinetics by age, sex, race/ethnicity, body weight, transplant type, or hepatic/renal impairment status. In phase II dose‐ranging studies, maribavir showed similar rates of CMV viral clearance across 400, 800, or 1200 mg b.i.d. groups, ranging from 62.5–70% in study 202 (NCT01611974) and 74–83% in study 203 (EudraCT 2010–024247‐32). In the phase III SOLSTICE trial (NCT02931539), maribavir 400 mg b.i.d. demonstrated superior CMV viremia clearance at week 8 versus investigator‐assigned treatments, with lower treatment discontinuation rates. Dysgeusia, nausea, vomiting, and diarrhea were commonly experienced adverse events among patients treated with maribavir in clinical trials.
Multiple Minute Digitate Hyperkeratosis: 10 Jahre nach Caccettas Algorithmus. Fallbericht und narrative Übersicht
Authors: Prados‐Carmona Alvaro , Prados‐Carmona Juan José , Ruiz‐Villaverde Ricardo , Navarro‐Triviño Francisco José 
Published: December 2023

ZusammenfassungDas klinische Erscheinungsbild und die histologischen Merkmale der Multiple Minute Digitate Hyperkeratosis sind bereits gut charakterisiert. Es besteht jedoch kein Konsens über die Behandlung dieser Erkrankung. Nach einer umfassenden Recherche in den Datenbanken MEDLINE, EMBASE, Web of Science und der Cochrane Library and Database of Systematic Reviews haben wir die vorliegenden klinischen Daten zu den therapeutischen Ansätzen zusammengefasst, die für diese Entität seit ihrer Erstbeschreibung im Jahr 1967 publiziert wurden. Zusätzliche Veröffentlichungen wurden in den Referenzen der gefundenen Artikel identifiziert. Fünfundsechzig Artikel wurden durchgesehen, sodass sich insgesamt 73 kompatible Fälle ergaben. Die histopathologischen Merkmale und die verschiedenen Klassifizierungen, die im Laufe der Zeit verwendet wurden, wurden ebenfalls berücksichtigt. Letztendlich schlagen wir die topische Behandlung mit 5% 5‐Fluorouracil in Kombination mit 10% Salicylsäure als eine mögliche Behandlung vor, die bei einer 51‐jährigen Frau in unserer Einrichtung erfolgreich angewendet wurde. Weitere Forschung in Form von prospektiven oder vergleichenden Studien werden empfohlen, um ein besseres Konzept für die Therapie dieser Krankheit zu entwickeln.
Lingua geographica: Welche Krankheit ist das?
Authors: Horiuchi Yasuhiro 
Published: December 2023

ZusammenfassungDie Lingua geographica oder benigne migratorische Glossitis ist eine besondere und eigentümliche Zungenerkrankung, die zu einem landkartenartigen Aussehen mit Atrophie der filiformen Papillen an verschiedenen Stellen der Zunge führt. Die Form der Läsionen ändert sich mit der Zeit. Die genaue Ätiologie ist nach wie vor unbekannt, allerdings wird ein Zusammenhang mit der lingualen Mikrobiota des Patienten vermutet. Auch auf eine Assoziation zwischen Lingua geographica und Psoriasis wird seit langem hingewiesen, und es bestehen histologische Ähnlichkeiten zwischen beiden. Neuere Erkenntnisse deuten zunehmend auf eine Beteiligung bestimmter oraler Bakterien hin. Im Folgenden werden diese Befunde anhand eines Überblicks über die aktuelle Literatur diskutiert.
HLA binding‐groove motifs are associated with myocarditis induction after Pfizer‐BioNTech BNT162b2 vaccination
Authors: Aharon Aviran , Benedek Gil , Barhoum Barhoum , Parnasa Elchanan , Magadle Nur , Perzon Ofer , Mevorach Dror 
Published: December 2023

AbstractBackground and AimsWe found a higher incidence of myocarditis in young males who had received at least two Pfizer‐BioNTech BNT162b2 vaccinations. The human leukocyte antigens (HLA) are known to play an important role in infectious and autoinflammatory diseases. We hypothesized that certain HLA alleles might be associated with vaccination‐induced myocarditis.MethodsHLA typing was performed using next‐generation sequencing technology with the Illumina Iseq100 platform. HLA class I and II loci were genotyped in 29 patients with post‐vaccination myocarditis and compared with HLA data from 300 healthy controls.ResultsWe demonstrate that the DRB1*14:01, DRB1*15:03 alleles and the motifs in HLA‐A − Leu62 and Gln63, which are part of binding pocket B and HLA‐DR Tyr47, His60, Arg70 and Glu74, which are part of binding pockets P4, P7 and P9, were significantly associated with disease susceptibility.ConclusionsOur findings suggest that immunogenetic fingerprints in HLA peptide‐binding grooves may affect the presentation of peptides derived from the Pfizer‐BioNTech BNT162b2 vaccination to T cells and induce an inflammatory process that results in myocarditis.
Serum bile acids associate with liver volume in polycystic liver disease and decrease upon treatment with lanreotide
Authors: Dekker Shosha E. I. , Bierau Jörgen , Giera Martin , Blomberg Niek , Drenth Joost P. H. , Mayboroda Oleg A. , de Fijter Johan W. , Soonawala Darius ,   DIPAK Consortium
Published: December 2023

AbstractBackgroundPolycystic liver disease (PLD) is a common extrarenal manifestation of autosomal dominant polycystic kidney disease (ADPKD). Bile acids may play a role in PLD pathogenesis. We performed a post‐hoc exploratory analysis of bile acids in ADPKD patients, who had participated in a trial on the effect of a somatostatin analogue. Our hypothesis was that serum bile acid levels increase in PLD, and that lanreotide, which reduces liver growth, may also reduce bile acid levels. Furthermore, in PLD, urinary excretion of bile acids might contribute to renal disease.MethodsWith liquid chromatography‐mass spectrometry, 11 bile acids in serum and 6 in urine were quantified in 105 PLD ADPKD patients and 52 age‐, sex‐, mutation‐ and eGFR‐matched non‐PLD ADPKD patients. Sampling was done at baseline and after 120 weeks of either lanreotide or standard care.ResultsBaseline serum levels of taurine‐ and glycine‐conjugated bile acids were higher in patients with larger livers. In PLD patients, multiple bile acids decreased upon treatment with lanreotide but remained stable in untreated subjects. Changes over time did not correlate with changes in liver volume. Urine bile acid levels did not change and did not correlate with renal disease progression.ConclusionIn ADPKD patients with PLD, baseline serum bile acids were associated with liver volume. Lanreotide reduced bile acid levels and has previously been shown to reduce liver volume. However, in this study, the decrease in bile acids was not associated with the change in liver volume.
Serological markers and long COVID—A rapid systematic review
Authors: Collins Erin , Philippe Elizabeth , Gravel Christopher A. , Hawken Steven , Langlois Marc‐André , Little Julian 
Published: December 2023

AbstractBackgroundLong COVID is highly heterogeneous, often debilitating, and may last for years after infection. The aetiology of long COVID remains uncertain. Examination of potential serological markers of long COVID, accounting for clinical covariates, may yield emergent pathophysiological insights.MethodsIn adherence to PRISMA guidelines, we carried out a rapid review of the literature. We searched Medline and Embase for primary observational studies that compared IgG response in individuals who experienced COVID‐19 symptoms persisting ≥12 weeks post‐infection with those who did not. We examined relationships between serological markers and long COVID status and investigated sources of inter‐study variability, such as severity of acute illness, long COVID symptoms assessed and target antigen(s).ResultsOf 8018 unique records, we identified 29 as being eligible for inclusion in synthesis. Definitions of long COVID varied. In studies that reported anti‐nucleocapsid (N) IgG (n = 10 studies; n = 989 participants in aggregate), full or partial anti‐Spike IgG (i.e. the whole trimer, S1 or S2 subgroups, or receptor binding domain, n = 19 studies; n = 2606 participants), or neutralizing response (n = 7 studies; n = 1123 participants), we did not find strong evidence to support any difference in serological markers between groups with and without persisting symptoms. However, most studies did not account for severity or level of care required during acute illness, and other potential confounders.ConclusionsPooling of studies would enable more robust exploration of clinical and serological predictors among diverse populations. However, substantial inter‐study variations hamper comparability. Standardized reporting practices would improve the quality, consistency and comprehension of study findings.
Kudzu vine (Pueraria montana var. lobata, Fabaceae): Invasive alien species of Union concern (EU Regulation 1143/2014) in Croatia
Authors: Boršić Igor , Kutleša Petra , de Groot Maarten , Jelaska Sven D. 
Published: December 2023

AbstractKudzu vine (Pueraria montana var. lobata; Fabaceae) was included on the list of invasive alien species of (European) Union concern in 2016, according to EU Regulation 1143/2014 on the prevention and management of the introduction and spread of invasive alien species. In the Flora Croatica Database this species is recorded under its synonym Pueraria thunbergiana Benth. for Split (Central Dalmatia), so its presence in Croatia was overlooked until it was discovered in Malinska on the island of Krk in August 2018. Recent field observations confirm that, in addition to Malinska, it is also present in Šestanovac (Central Dalmatia), the Trsteno Arboretum and in Dubrovnik (South Dalmatia). Localities in Gradac and Seget (Central Dalmatia) were also recently discovered. Literature and herbaria data as well as internet resources indicate that kudzu vine has been historically grown as an ornamental species in Croatia. Considering its invasiveness as reported in several countries and its ornamental uses, other unknown localities of cultivated or naturalized kudzu vine could exist along the Croatian coast.
Neurotensin counteracts hair growth inhibition induced by chronic restraint stress
Authors: Chen Lingjing , Yu Qing , Guo Feiying , Wang Xuewen , Cai Zhenying , Zhou Qiang 
Published: December 2023

AbstractStress has been considered as a potential trigger for hair loss through the neuroendocrine‐hair follicle (HF) axis. Neurotensin (NTS), a neuropeptide, is known to be dysregulated in the inflammatory‐associated skin diseases. However, the precise role of NTS in stress‐induced hair loss is unclear. To investigate the function and potential mechanisms of NTS in stress‐induced hair growth inhibition, we initially detected the expression of neurotensin receptor (Ntsr) and NTS in the skin tissues of stressed mice by RNA‐sequencing and ELISA. We found chronic restraint stress (CRS) significantly decreased the expression of both NTS and Ntsr in the skin tissues of mice. Intracutaneous injection of NTS effectively counteracted CRS‐induced inhibition of hair growth in mice. Furthermore, NTS regulated a total of 1093 genes expression in human dermal papilla cells (HDPC), with 591 genes being up‐regulated and 502 genes being down‐regulated. GO analysis showed DNA replication, cell cycle, integral component of plasma membrane and angiogenesis‐associated genes were significantly regulated by NTS. KEGG enrichment demonstrated that NTS also regulated genes related to the Hippo signalling pathway, axon guidance, cytokine–cytokine receptor interaction and Wnt signalling pathway in HDPC. Our results not only uncovered the potential effects of NTS on stress‐induced hair growth inhibition but also provided an understanding of the mechanisms at the gene transcriptional level.
Variations of theKjeldahlmethod for assessing nitrogen concentration in tropical forages
Authors: Quirino Daiana Francisca , Lima Nicole Stephane Abreu , Palma Malber Nathan Nobre , de Oliveira Franco Marcia , Detmann Edenio 
Published: December 2023

AbstractNitrogen (N) is one of the most important components of feeds and its quantification allows estimating protein equivalents, an important characteristic for diet formulation in ruminant nutrition. We aimed to evaluate N recovery in tropical forages using the Kjeldahl method with modifications involving a pre‐digestion step with salicylic acid and, or a partial replacement of copper sulfate by titanium dioxide as a catalyst. Forty‐eight study materials (i.e., tropical forages) were evaluated. Kjeldahl standard procedure was based on acid digestion with sodium sulfate and copper sulfate (20:1), followed by steam distillation in sodium hydroxide and titration with hydrochloric acid. The Kjeldahl variations were: salicylic acid as pre‐treatment before digestion, titanium dioxide replacing 50% of copper sulfate as catalyst in the digestion mixture, and salicylic acid and titanium as described above. The Dumas method was used as standard method to verify N recovery through Kjeldahl procedures. The N concentrations of the study materials (Dumas method) ranged from 1.9 to 28.3 g/kg as‐is. We found that all the methods were strongly and positively associated with each other (p < .01). All Kjeldahl methods produced N concentrations different from those obtained by the Dumas method (p < .01). The N recovery ranged from 0.971 to 0.980 for the different Kjeldahl methods. However, we did not find any difference between the different Kjeldahl methods regarding N concentrations (p≥ .89). The N recovery of the Kjeldahl method is not influenced by a pre‐digestion with salicylic acid or by the partial replacement of copper sulfate with titanium dioxide as a catalyst.
BETWEEN THE ORBITS: TRANSLATING SHARON DODUA OTOO'S ADAS RAUM
Authors: Cho‐Polizzi Jon 
Published: December 2023

ABSTRACTThis paper examines theoretical and practical questions involved in the translation of Sharon Dodua Otoo's transnational and polyphonic novel Adas Raum. Using translation theory and the Benjaminian notion of a translation's ‘Fortleben’, I build on my concept of ‘conversive reading’, as well as on extensive real‐time collaboration with Otoo and fellow translators to ask: How does one negotiate questions of identity, positionality and voice in a work whose narrative so intricately intertwines these dimensions? How can the literary inheritance which informs a source text influence its translation into the target language? To what extent must a successful translation move away from the source text to facilitate its nuances in the target language? Expanding on the experience and practice of translating this novel, I demonstrate that my understanding of translation as an ongoing process represents a renegotiation of the source – building upon a work's literary forebears and diverging, when necessary, from the language of the source to best facilitate voice and reception in the cultural context of the target language.
Superhydrophobic tin oxide nanostructures coated on copper plates: Wettability tuning by the etching medium
Authors: Amiri Elham Aghajanpour , Norouzbeig Reza , Velayi Elmira 
Published: December 2023

AbstractIn the current work, the chemical etching process and hydrothermal method were used to create bio‐inspired superhydrophobic fluorine‐free tin oxide nanostructures on copper plates. Taguchi's experimental design was also used in investigating coating wettability characteristics based on fabrication parameters. Statistical analysis results demonstrated that the optimal superhydrophobic sample with a water contact angle of 163.40° ± 1.42° and contact angle hysteresis of 3.00° ± 0.80° could be fabricated under the following conditions: sodium hydroxide (2.00 M) as an etching solution, urea‐to‐tin chloride ratio 2.5:1, and 2.00 h reaction times. The effects of each synthesis parameter on the obtained sample's superhydrophobicity were evaluated through multiple one‐variable‐at‐a‐time experiments. Testing the chemical stability of the optimal sample revealed that it was more resistant to deterioration in an alkaline environment (8–10) than in an acidic environment (4–6). The resulting superhydrophobic sample was analyzed by a delay test for water droplets freezing on its surface to determine whether ice formed and accumulated. The created bio‐inspired honeycomb‐like nanocoating demonstrated exceptional mechanical robustness and good anti‐icing performance after 10 consecutive icing cycles. These results indicated that superhydrophobic coatings could be easily and economically produced without using fluoropolymers and silanes on aluminum substrates.
Influence of sintering atmosphere on the formation of ZrSiO4 by solid‐state sintering method
Authors: Dan Hui , Li Jiajing , Zhao Dandan , Lei Hongyue , Guo Zhongxiang , Xiang Yucheng , Chen Yisheng , Ding Yi 
Published: December 2023

AbstractExploring the influence of sintering atmosphere on the formation of ZrSiO4 is of great significance. Herein, ZrSiO4 ceramics were prepared by the solid‐state reactive sintering method under different atmospheres (air, N2, vacuum, and Ar + 5%H2). The influence of sintering atmosphere on the phase and microstructure evolutions of the obtained ceramics was investigated. It was found that ZrSiO4 ceramics could be prepared under air atmosphere, whereas ZrO2–SiO2 glass ceramics were obtained under N2, vacuum, and Ar + 5%H2 atmosphere, which may be due to the fact that the oxygen‐deficient environment inhibits the transformation of ZrO2 to tetragonal phase (t‐ZrO2) and the crystallization of amorphous SiO2. The results demonstrated that t‐ZrO2 and c‐SiO2 were beneficial for the formation of ZrSiO4. The ZrSiO4 conversion fraction was up to 96.16% under air atmosphere at 1450°C for 6 h. Furthermore, the predominant formation mechanism of ZrSiO4 was the reaction between t‐ZrO2 and c‐SiO2.
Energy‐storage properties of (0.7Bi0.65Na0.35Fe0.3Ti0.7O3–0.3Sr0.85Bi0.1TiO3)–NaTaO3 relaxor under low electric fields
Authors: Yang Yang , Ren Pengrong , Ma Ning , Li Xiangyuan , Qi Xiangcheng , Wan Yuhui 
Published: December 2023

AbstractCurrently, the energy‐storage properties of dielectric ceramic capacitors have aroused wide attention; however, most materials exhibiting excellent energy‐storage properties are based on high electric fields, which increase the cost of insulation technology. Herein, the energy‐storage and charge–discharge properties of (1 − x)(0.7Bi0.65Na0.35Fe0.3Ti0.7O3–0.3Sr0.85Bi0.1TiO3)–xNaTaO3 (x = 0.03–0.18, abbreviated as 100xNT) ceramics are investigated. 9NT achieves superior energy‐storage properties under a low electric field of 210 kV/cm, with an energy‐storage density (Wrec) of 3.44 J/cm3 and efficiency (η) of 86.6%. The energy‐storage properties exhibit excellent frequency stability in 3–100 Hz as well as temperature stability between 25 and 175°C. Furthermore, the charge–discharge performance features a high‐power density (PD = 67.04 MW/cm3), and an ultrafast discharge speed (t0.9 = 52 ns). This work paves a new way to explore energy‐storage competitive materials under low electric fields.
Mental health literacy in Polynesian Native Hawaiian and Other Pacific Islanders
Authors: Snow Kealoha Sarah Reiko , Merrill Katreena , Macintosh Janelle , Thomas Michael , Miles Leslie 
Published: December 2023

AbstractThe high prevalence of mental health problems and underutilization of mental health treatment are more severe among the Native Hawaiian and Other Pacific Islander (NHPI) populations and remain misunderstood and understudied. Examining mental health literacy (MHL) – the knowledge and beliefs about mental disorders – aids their recognition, management, or prevention – has been shown to identify barriers to seeking and receiving care. This study aimed to assess the level of MHL in NHPIs and identify associated demographic variables. Data for this cross‐sectional study were collected from 298 US NHPIs via an online questionnaire of the Mental Health Literacy Scale (MHLS). The overall mean MHLS score was 121 (SD = 17.3), with statistically significant higher scores in female participants, >31 years old, Tongan, more educated, and with higher income. This study demonstrated that overall MHL is comparable among NHPI compared to the current literature. However, NHPI men ≤30 years old and with lower income had lower MHL, which may be linked to the mental health disparities specific to this population. Current interventions should focus on increasing knowledge of risk factors, causes, self‐treatments, and available professional help regarding mental disorders. Efforts to improve the MHL of NHPI should target men ≤30 years with lower income (<$50 000).