bluuebunny/crossref_metadata_2025_split huggingface dataset:
A phenomenological exploration of the mental health experiences of young women with diminished ovarian reserve
Authors: Woods Brittany M. , Bray Leigh Ann , Campbell Sukhkamal B. , Holland Aimee , Mrug Sylvie , Ladores Sigrid 
Published: October 2023

AbstractInfertility is a reproductive disease affecting one in six individuals that renders an individual unable to conceive. One cause of infertility is diminished ovarian reserve (DOR), which reduces the quantity and/or quality of a female's oocyte pool. Although typically indicating normal ovarian aging during the late 30s and early 40s, DOR can also impact younger women, increasing their risk for psychological distress from an unexpected diagnosis of infertility. A phenomenological approach examined the mental health experiences and perceptions of infertility‐related mental health care of young women with DOR. Women diagnosed with DOR by age 35 in the United States who experienced emotional distress during infertility were recruited from infertility‐specific social media and via snowball sampling. Participants completed a demographic survey and semi‐structured individual interview that was audio‐recorded, transcribed verbatim, and analyzed using a phenomenological approach. Ten women ages 27–41 completed the study. On average, participants were 30 years of age at the time of DOR diagnosis (age range 25–35), primarily Caucasian (90%), and married (90%). Two main themes were found: (1) Young women with DOR feel like a “forgotten community” coping with an invisible disease; and (2) Not all fertility clinics are created equal. Participants perceived their diagnosis as devastating and hopeless and urged others to find a provider with ample experience treating patients with DOR. This study helped to understand how young women with DOR perceive their mental health and identified a significant need for advancing towards more holistic infertility healthcare that encompasses both physical and mental health.
Mechanical properties and corrosion protection performance of micro/nano alumina fillers coated steel
Authors: Abd El‐Aziz Kh. , Megahed M. , Saber D. 
Published: October 2023

AbstractSteel is considered the most widely used metal because of its excellent strength and comparatively low‐production cost. Preventing steel corrosion will be a top priority in industry. This work investigates the influence of an epoxy resin liner to steel filled with different percentages (1, 2, and 3 wt%) of either micro or nanoparticles of alumina (Al2O3) on both bending properties and corrosion resistance. To test for barrier resistance, the coated steel samples were submerged in a citric acid and saline solution. In comparison with pure epoxy coatings, the addition of nano and micro alumina (Al2O3) particles enhanced the corrosion resistance, bending strength, and bending strain under dry and wet conditions. Furthermore, under both dry and wet circumstances, the bending strain rose dramatically with the addition of micro and nano fillers. The 1 wt% of Al2O3 nanoparticles coated steel exhibited the maximum bending strength of 492.81 and 436.9 MPa under wet and dry conditions, respectively. Moreover, the micro filled steel of 1 wt% Al2O3 micro fillers exhibited a 483.7 and 319.08 MPa bending strength under wet and dry circumstances, respectively. Stepwise graded micro/nanocomposite coatings showed good bending and corrosion properties in both dry and wet conditions.Highlights
Coating is an economical means to protect steel structures from deterioration.
The coating on the steel on each side is epoxy filled with 1, 2, and 3 wt% micro or nano particles of alumina (Al2O3).
Bending and corrosion resistance properties of micro/nanocomposite coated specimens were investigated and compared with pure epoxy coating.
The lined steel specimens were tested for corrosion resistance by immersing them in saline solution and citric acid medium.
Under dry and wet conditions, the addition of alumina (Al2O3) particles to epoxy coatings enhanced the corrosion resistance, bending strength, and bending strain compared with pure coating.
Disease resistance in whitebark pine and potential for restoration of a threatened species
Authors: Sniezko Richard A. , Johnson Jeremy S. , Kegley Angelia , Danchok Robert 
Published: October 2023

Societal impact statementForests world‐wide are being negatively affected by non‐native, invasive pathogens and pests, and some tree species face uncertain futures. To retain these species as components of future forests, the rare genetic resistance that exists needs to be identified and harnessed. The applied tree improvement program for whitebark pine (Pinus albicaulis), a threatened (in the United States) and endangered (in Canada) keystone species in many forests in western North America, provides an example of what can be accomplished in a relatively short timeframe. The level and frequency of resistance vary by location, and this information will be used to implement the national restoration plan.Summary

Forest trees face serious threats from non‐native diseases and pests, often causing high mortality of both the existing trees and regeneration. Developing populations with genetic resistance can help restore forests and retain affected species. Resistance programs have historically focused on species of high economic importance; however, the threats to species of little direct economic value that provide other important ecosystem services are also great.
We examined the frequency, level, and geographic variation in genetic resistance to white pine blister rust in the threatened Pinus albicaulis (whitebark pine), a keystone species in high‐elevation ecosystems in western North America. In the two trials reported here, 2‐year‐old seedling progeny of 225 whitebark pine parent trees were inoculated with two geographic sources of the fungal pathogen Cronartium ribicola and evaluated over 5 years for an array of resistance traits. The trials focused primarily on parent trees from the Oregon and Washington populations.
We found unexpectedly high levels of quantitative resistance in some seedling families and populations, in stark contrast to levels observed in similar resistance programs with other North American white pine species such as Pinus monticola and Pinus lambertiana.
The level of resistance found in some whitebark pine populations provides optimism about potential recovery efforts for this species. Restoration efforts are underway by government agencies, tribes, and non‐government organizations in both the United States and Canada. These efforts may help boost support for applied genetic resistance programs in other forest tree species severely affected by non‐native pathogens or pests.
Coronaviruses spike glycoprotein endodomains: The sequence and structure‐based comprehensive study
Authors: Kumar Prateek , Bhardwaj Aparna , Mukherjee Bodhidipra , Joshi Richa , Giri Rajanish 
Published: October 2023

AbstractAny protein's flexibility or region makes it available to interact with many biomolecules in the cell. Specifically, such interactions in viruses help them to perform more functions despite having a smaller genome. Therefore, these flexible regions can be exciting and essential targets to be explored for their role in pathogenicity and therapeutic developments as they achieve essential interactions. In the continuation with our previous study on disordered analysis of SARS‐CoV‐2 spike protein's cytoplasmic tail (CTR), or endodomain, here we have explored the endodomain's disordered potential of six other coronaviruses using multiple bioinformatics approaches and molecular dynamics simulations. Based on the comprehensive analysis of its sequence and structural composition, we report the varying disorder propensity in endodomains of spike proteins of coronaviruses. The observations of this study may help to understand the importance of spike glycoprotein endodomain and creating therapeutic interventions against them.
Effects of (−)‐MBP, a novel 5‐HT2C agonist and 5‐HT2A/2B antagonist/inverse agonist on brain activity: A phMRI study on awake mice
Authors: Sathe Preeti K. , Ramdasi Gargi R. , Giammatteo Kaylie , Beauzile Harvens , Wang Shuyue , Zhang Heng , Kulkarni Praveen , Booth Raymond G. , Ferris Craig F. 
Published: October 2023

AbstractA novel serotonin ligand (−)‐MBP was developed for the treatment of schizophrenia that has 5‐HT2A/2B antagonist activity together with 5‐HT2C agonist activity. The multi‐functional activity of this novel drug candidate was characterized using pharmacological magnetic resonance imaging. It was hypothesized (−)‐MBP would affect activity in brain areas associated with sensory perception. Adult male mice were given one of three doses of (−)‐MBP (3.0, 10, 18 mg/kg) or vehicle while fully awake during the MRI scanning session and imaged for 15 min post I.P. injection. BOLD functional imaging was used to follow changes in global brain activity. Data for each treatment were registered to a 3D MRI mouse brain atlas providing site‐specific information on 132 different brain areas. There was a dose‐dependent decrease in positive BOLD signal in numerous brain regions, especially thalamus, cerebrum, and limbic cortex. The 3.0 mg/kg dose had the greatest effect on positive BOLD while the 18 mg/kg dose was less effective. Conversely, the 18 mg/kg dose showed the greatest negative BOLD response while the 3.0 mg/kg showed the least. The prominent activation of the thalamus and cerebrum included the neural circuitry associated with Papez circuit of emotional experience. When compared to vehicle, the 3.0 mg dose affected all sensory modalities, for example, olfactory, somatosensory, motor, and auditory except for the visual cortex. These findings show that (−)‐MBP, a ligand with both 5‐HT2A/2B antagonist and 5‐HT2C agonist activities, interacts with thalamocortical circuitry and impacts areas involved in sensory perception.
Toward improved predictions of pharmacokinetics of transported drugs in hepatic impairment: Insights from the extended clearance model
Authors: Storelli Flavia , Ladumor Mayur K. , Liang Xiaomin , Lai Yurong , Chothe Paresh P. , Enogieru Osatohanmwen J. , Evers Raymond , Unadkat Jashvant D. 
Published: October 2023

AbstractHepatic impairment (HI) moderately (<5‐fold) affects the systemic exposure (i.e., area under the plasma concentration–time curve [AUC]) of drugs that are substrates of the hepatic sinusoidal organic anion transporting polypeptide (OATP) transporters and are excreted unchanged in the bile and/or urine. However, the effect of HI on their AUC is much greater (>10‐fold) for drugs that are also substrates of cytochrome P450 (CYP) 3A enzymes. Using the extended clearance model, through simulations, we identified the ratio of sinusoidal efflux clearance (CL) over the sum of metabolic and biliary CLs as important in predicting the impact of HI on the AUC of dual OATP/CYP3A substrates. Because HI may reduce hepatic CYP3A‐mediated CL to a greater extent than biliary efflux CL, the greater the contribution of the former versus the latter, the greater the impact of HI on drug AUC ratio (AUCRHI). Using physiologically‐based pharmacokinetic modeling and simulation, we predicted relatively well the AUCRHI of OATP substrates that are not significantly metabolized (pitavastatin, rosuvastatin, valsartan, and gadoxetic acid). However, there was a trend toward underprediction of the AUCRHI of the dual OATP/CYP3A4 substrates fimasartan and atorvastatin. These predictions improved when the sinusoidal efflux CL of these two drugs was increased in healthy volunteers (i.e., before incorporating the effect of HI), and by modifying the directionality of its modulation by HI (i.e., increase or decrease). To accurately predict the effect of HI on AUC of hepatobiliary cleared drugs it is important to accurately predict all hepatobiliary pathways, including sinusoidal efflux CL.
Irrigation contrasts through the morning transition
Authors: Brooke J. K. , Best M. J. , Lock A. P. , Osborne S. R. , Price J. , Cuxart J. , Boone A. , Canut‐Rocafort G. , Hartogensis O. K. , Roy A. 
Published: October 2023

AbstractThe Land surface Interactions with the Atmosphere over the Iberian Semi‐arid Environment (LIAISE) campaign was conducted in July 2021, primarily to investigate the role of irrigation in modulating the boundary‐layer evolution in the Catalan region of northeastern Spain. Contrasts in near‐surface meteorological parameters and boundary‐layer thermodynamic profiles at an irrigated and rainfed (arid) site were established during the morning transition. Evapotranspriation dominated the flux partitioning at the irrigated site (Bowen ratio of 0.07–1.1), whilst sensible heat flux dominated at the rainfed (arid) site (Bowen ratio greater than 10.0). The cumulative evapotranspiration during July 2021 was a factor of 10 greater at the irrigated site than at the rainfed (arid) site. The presence of irrigation was shown to modulate the vertical gradients of turbulence, temperature, and moisture. Irrigation is shown to have a significant effect on the development of the boundary layer, including during the morning transition. The morning transition mean buoyancy flux was 2.8 times smaller at the irrigated site (1.1 ms) compared with the rainfed (arid) site (3.1 ms), with a resultant delay in the near‐surface buoyancy‐flux crossover time (30–90 min) at the irrigated site. At the start of the morning transition (sunrise), the average screen‐level (50‐m) temperature was  K ( K) colder at the irrigated site relative to the rainfed (arid) site. The colder temperatures at sunrise at the irrigated site are predominantly the result of a colder boundary‐layer thermodynamic profile from the previous day. At the end of the morning transition (convective onset), temperature differences between the two sites extend through much of the boundary layer and increase in magnitude. The average screen‐level (50‐m) temperature difference was  K ( K) colder at the irrigated site relative to the rainfed (arid) site. There was considerable day‐to‐day variability in temperature contrasts at a regional level ( to  K).
Two‐stage and three‐stage recursive gradient identification of Hammerstein nonlinear systems based on the key term separation
Authors: Lv Lei , Sun Wei , Pan Jian 
Published: October 2023

AbstractThis article explores recursive algorithms for parameter identification issues of Hammerstein output‐error systems. The proposed approach includes the key term separation auxiliary model recursive gradient algorithm, which utilizes the gradient search and the key term separation. To enhance computational efficiency, the system is decomposed into two or three subsystems through the hierarchical identification principle. Based on this, a key term separation based auxiliary model two‐stage recursive gradient algorithm and a key term separation based auxiliary model three‐stage recursive gradient algorithm are presented. The simulation results verify the validity of the obtained algorithms.
LGBTQIA+ victimization: A theoretical discourse
Authors: Sibanyoni Ephraim Kevin , Mkhize Simangele , Amali Sadiq Ewaoda 
Published: October 2023

AbstractThis paper draws on social construction and broken window theories as theoretical frameworks to explain how LGBTQIA+ are victimized due to discrimination and nonacceptance in their communities. Homosexual groups face a high risk of violence, discrimination, and prejudice because of their sexual orientation. They are stigmatized for their perceived sexual and/or gender “deviance” and rejected by the “straight” members of society, leading to discrimination and violation. This discrimination often leads to homophobia, which can result in violent attacks such as “corrective rape,” common assault, assault causing grievous bodily harm (GBH), and other crimes. Many people view homosexuality as a sickness, a sin, and even antihuman. The victimization of LGBTQIA+ is motivated by hate and intolerance toward their sexuality, leading to trauma, depression, isolation, and fear. This victimization has a significant impact on their lives, and many still live in fear, feeling unprotected. Consequently, many remain “in the closet” due to fear of victimization.
The impact of COVID‐19 trauma on healthcare workers: Examining the relationship between stress and growth through the lens of memory
Authors: Öner Sezin , Bilgin Ezgi , Çağlar Emine Şeyma 
Published: October 2023

AbstractThe COVID‐19 pandemic constituted tremendous traumatic stress among the frontline healthcare workers. In the present study, we investigated relationships of two types of rumination, namely brooding and reflection, with traumatic stress and post‐traumatic growth and the mediating role of recollective experience in these relationships. A total of 88 healthcare workers (75% female, Mage = 54.91) actively providing service to COVID‐19 patients reported two memories of events that impacted them the most at the first peak of the pandemic and rated their recollective experience (i.e., phenomenological characteristics of memories). We used structural equation modelling to test whether recollective experience mediated the link of brooding and reflection with post‐trauma reactions of stress and growth. The findings showed that brooding and reflection were associated with higher levels of traumatic stress and post‐traumatic growth. Importantly, recollective experience mediated the relationship of rumination with traumatic stress but this differed for the type of rumination. Higher brooding was associated with greater traumatic stress and that relationship was independent of how well the memories were recollected, while for reflection, high reflection was associated with stronger recollective experience, which predicted higher traumatic stress and post‐traumatic growth. The present study shows the functional dimensions of reflective rumination and presents novel findings that demonstrates the discrete mnemonic mechanisms underlying the association between brooding, reflection, and post‐trauma reactions.
Is boredom at work bad for your health? Examining the links between job boredom and autonomic nervous system dysfunction
Authors: Seppälä Piia , Harju Lotta , Virkkala Jussi , Hakanen Jari J. 
Published: October 2023

AbstractJob boredom refers to an unpleasant state of passiveness at work that has been found to negatively relate to self‐reported health. To date, however, the relation between job boredom and physiological indicators of health has not been examined. The present study investigates whether job boredom relates to dysfunction in autonomic nervous system (ANS) activity as indicated by reduced heart rate variability (HRV) during night sleep. The sample of this study consisted of Finnish public sector workers (n = 125). Job boredom was assessed with an electronic questionnaire and HRV with an ambulatory monitoring period of two nights of sleep. The results supported the hypothesis by showing a negative relation between job boredom and HRV, after controlling for demographic and lifestyle factors. The findings extend previous knowledge on the detrimental consequences of job boredom by showing that it is related to dysfunction in ANS activity. Consequently, it is important to acknowledge boredom at work as a threat to occupational health and well‐being and pay more attention to how it can be prevented at workplaces.
Study on seismic performance test and calculation method of recycled steel fiber reinforced concrete shear wall
Authors: Li Yan , Li Dong‐yi , Zhao Shan‐mu , Wang Xiao‐peng 
Published: October 2023

SummaryRecycled steel wire is taken from used tires, and by procedures like mechanical cutting and friction treatment, it can be converted into industrial recycled steel fiber that meets precise criteria. Such green fiber may effectively limit the growth of fractures in concrete and diffuse the fracture energy of concrete when incorporated into concrete. An investigation of the effects of materials and horizontal reinforcement spacing on the seismic performance of shear wall specimens is presented in this research. The test and numerical simulation findings indicate that the RSFRC (recycled steel fiber reinforced concrete) shear wall's fracture is substantially narrower than that of a conventional shear wall and that the shear carrying capacity and deformation ductility of the shear wall have been greatly enhanced. The energy dissipation capacity of the RSFRC shear wall specimen with varying horizontal reinforcement spacing is significantly enhanced when compared to the conventional shear wall, and the ultimate displacements are reduced. RSFRC shear wall specimen has higher stiffness in the early stage, and the overall stiffness decreases slowly. With the decrease of fiber volume fraction of RSFRC shear wall in a certain range, the shear bearing capacity and stiffness of the model will decrease slightly, but the ductility will increase significantly. Compared with the RSFRC shear wall with fiber aspect ratio of 40 and 25, the bearing capacity and ductility of the two are close, but the RSFRC shear wall with low aspect ratio is slightly insufficient. When the axial compression ratio is in the range of 0.2–0.4, the horizontal shear capacity of RSFRC shear wall increases with the increase of vertical load, but the maximum horizontal displacement becomes smaller, and the model is damaged by compression. Using theoretical calculation, this work also creates the simplified calculation method and restoring force model for the bearing capacity of the diagonal section of RSFRC shear wall. The observed findings correspond well with the test hysteresis curve and may serve as a benchmark for future study. This study provides a new research direction for the seismic performance of RSFRC structures, as well as a solid theoretical foundation and promotion for future research.
ATG16L1 rs2241880/T300A increases susceptibility to perianal Crohn's disease: An updated meta‐analysis on inflammatory bowel disease risk and clinical outcomes
Authors: Simovic Isidora , Hilmi Ida , Ng Ruey Terng , Chew Kee Seang , Wong Shin Yee , Lee Way Seah , Riordan Stephen , Castaño‐Rodríguez Natalia 
Published: October 2023

AbstractBackgroundATG16L1 plays a fundamental role in the degradative intracellular pathway known as autophagy, being a mediator of inflammation and microbial homeostasis. The variant rs2241880 can diminish these capabilities, potentially contributing to inflammatory bowel disease (IBD) pathogenesis.ObjectivesTo perform an updated meta‐analysis on the association between ATG16L1 rs2241880 and IBD susceptibility by exploring the impact of age, ethnicity, and geography. Moreover, to investigate the association between rs2241880 and clinical features.MethodsLiterature searches up until September 2022 across 7 electronic public databases were performed for all case‐control studies on ATG16L1 rs2241880 and IBD. Pooled odds ratios (ORP) and 95% CI were calculated under the random effects model.ResultsOur analyses included a total of 30,606 IBD patients, comprising 21,270 Crohn's disease (CD) and 9336 ulcerative colitis (UC) patients, and 33,329 controls. ATG16L1 rs2241880 was significantly associated with CD susceptibility, where the A allele was protective (ORP: 0.74, 95% CI: 0.72–0.77, p‐value: <0.001), while the G allele was a risk factor (ORP: 1.23, 95% CI: 1.09–1.39, p‐value: 0.001), depending on the minor allele frequencies observed in this multi‐ancestry study sample. rs2241880 was predominantly relevant in Caucasians from North America and Europe, and in Latin American populations. Importantly, CD patients harbouring the G allele were significantly more predisposed to perianal disease (ORP: 1.21, 95% CI: 1.07–1.38, p‐value: 0.003).ConclusionsATG16L1 rs2241880 (G allele) is a consistent risk factor for IBD in Caucasian cohorts and influences clinical outcomes. As its role in non‐Caucasian populations remains ambiguous, further studies in under‐reported populations are necessary.