bluuebunny/crossref_metadata_2025_split huggingface dataset:
The development of compulsive coping behavior depends on dorsolateral striatum dopamine-dependent mechanisms
Authors: Marti-Prats Lucia , Giuliano Chiara , Domi Ana , Puaud Mickaël , Peña-Oliver Yolanda , Fouyssac Maxime , McKenzie Colin , Everitt Barry J. , Belin David 
Published: September 2023

AbstractHumans greatly differ in how they cope with stress, a natural behavior learnt through negative reinforcement. Some individuals engage in displacement activities, others in exercise or comfort eating, and others still in alcohol use. Across species, adjunctive behaviors, such as polydipsic drinking, are used as a form of displacement activity that reduces stress. Some individuals, in particular those that use alcohol to self-medicate, tend to lose control over such coping behaviors, which become excessive and compulsive. However, the psychological and neural mechanisms underlying this individual vulnerability have not been elucidated. Here we tested the hypothesis that the development of compulsive adjunctive behaviors stems from the functional engagement of the dorsolateral striatum (DLS) dopamine-dependent habit system after a prolonged history of adjunctive responding. We measured in longitudinal studies in male Sprague Dawley rats the sensitivity of early established vs compulsive polydipsic water or alcohol drinking to a bilateral infusion into the anterior DLS (aDLS) of the dopamine receptor antagonist α-flupentixol. While most rats acquired a polydipsic drinking response with water, others only did so with alcohol. Whether drinking water or alcohol, the acquisition of this coping response was insensitive to aDLS dopamine receptor blockade. In contrast, after prolonged experience, adjunctive drinking became dependent on aDLS dopamine at a time when it was compulsive in vulnerable individuals. These data suggest that habits may develop out of negative reinforcement and that the engagement of their underlying striatal system is necessary for the manifestation of compulsive adjunctive behaviors.
Curved adhesions mediate cell attachment to soft matrix fibres in three dimensions
Authors: Zhang Wei , Lu Chih-Hao , Nakamoto Melissa L. , Tsai Ching-Ting , Roy Anish R. , Lee Christina E. , Yang Yang , Jahed Zeinab , Li Xiao , Cui Bianxiao 
Published: September 2023

AbstractIntegrin-mediated focal adhesions are the primary architectures that transmit forces between the extracellular matrix (ECM) and the actin cytoskeleton. Although focal adhesions are abundant on rigid and flat substrates that support high mechanical tensions, they are sparse in soft three-dimensional (3D) environments. Here we report curvature-dependent integrin-mediated adhesions called curved adhesions. Their formation is regulated by the membrane curvatures imposed by the topography of ECM protein fibres. Curved adhesions are mediated by integrin ɑvβ5 and are molecularly distinct from focal adhesions and clathrin lattices. The molecular mechanism involves a previously unknown interaction between integrin β5 and a curvature-sensing protein, FCHo2. We find that curved adhesions are prevalent in physiological conditions, and disruption of curved adhesions inhibits the migration of some cancer cell lines in 3D fibre matrices. These findings provide a mechanism for cell anchorage to natural protein fibres and suggest that curved adhesions may serve as a potential therapeutic target.
Garetosmab in fibrodysplasia ossificans progressiva: a randomized, double-blind, placebo-controlled phase 2 trial
Authors: Di Rocco Maja , Forleo-Neto Eduardo , Pignolo Robert J. , Keen Richard , Orcel Philippe , Funck-Brentano Thomas , Roux Christian , Kolta Sami , Madeo Annalisa , Bubbear Judith S. , Tabarkiewicz Jacek , Szczepanek Małgorzata , Bachiller-Corral Javier , Cheung Angela M. , Dahir Kathryn M. , Botman Esmée , Raijmakers Pieter G. , Al Mukaddam Mona , Tile Lianne , Portal-Celhay Cynthia , Sarkar Neena , Hou Peijie , Musser Bret J. , Boyapati Anita , Mohammadi Kusha , Mellis Scott J. , Rankin Andrew J. , Economides Aris N. , Trotter Dinko Gonzalez , Herman Gary A. , O’Meara Sarah J. , DelGizzi Richard , Weinreich David M. , Yancopoulos George D. , Eekhoff E. Marelise W. , Kaplan Frederick S. 
Published: September 2023

AbstractFibrodysplasia ossificans progressiva (FOP) is a rare disease characterized by heterotopic ossification (HO) in connective tissues and painful flare-ups. In the phase 2 LUMINA-1 trial, adult patients with FOP were randomized to garetosmab, an activin A-blocking antibody (n = 20) or placebo (n = 24) in period 1 (28 weeks), followed by an open-label period 2 (28 weeks; n = 43). The primary end points were safety and for period 1, the activity and size of HO lesions. All patients experienced at least one treatment-emergent adverse event during period 1, notably epistaxis, madarosis and skin abscesses. Five deaths (5 of 44; 11.4%) occurred in the open-label period and, while considered unlikely to be related, causality cannot be ruled out. The primary efficacy end point in period 1 (total lesion activity by PET–CT) was not met (P = 0.0741). As the development of new HO lesions was suppressed in period 1, the primary efficacy end point in period 2 was prospectively changed to the number of new HO lesions versus period 1. No placebo patients crossing over to garetosmab developed new HO lesions (0% in period 2 versus 40.9% in period 1; P = 0.0027). Further investigation of garetosmab in FOP is ongoing. ClinicalTrials.gov identifier NCT03188666.
Live-cell three-dimensional single-molecule tracking reveals modulation of enhancer dynamics by NuRD
Authors: Basu S. , Shukron O. , Hall D. , Parutto P. , Ponjavic A. , Shah D. , Boucher W. , Lando D. , Zhang W. , Reynolds N. , Sober L. H. , Jartseva A. , Ragheb R. , Ma X. , Cramard J. , Floyd R. , Balmer J. , Drury T. A. , Carr A. R. , Needham L.-M. , Aubert A. , Communie G. , Gor K. , Steindel M. , Morey L. , Blanco E. , Bartke T. , Di Croce L. , Berger I. , Schaffitzel C. , Lee S. F. , Stevens T. J. , Klenerman D. , Hendrich B. D. , Holcman D. , Laue E. D. 
Published: September 2023

AbstractTo understand how the nucleosome remodeling and deacetylase (NuRD) complex regulates enhancers and enhancer–promoter interactions, we have developed an approach to segment and extract key biophysical parameters from live-cell three-dimensional single-molecule trajectories. Unexpectedly, this has revealed that NuRD binds to chromatin for minutes, decompacts chromatin structure and increases enhancer dynamics. We also uncovered a rare fast-diffusing state of enhancers and found that NuRD restricts the time spent in this state. Hi-C and Cut&Run experiments revealed that NuRD modulates enhancer–promoter interactions in active chromatin, allowing them to contact each other over longer distances. Furthermore, NuRD leads to a marked redistribution of CTCF and, in particular, cohesin. We propose that NuRD promotes a decondensed chromatin environment, where enhancers and promoters can contact each other over longer distances, and where the resetting of enhancer–promoter interactions brought about by the fast decondensed chromatin motions is reduced, leading to more stable, long-lived enhancer–promoter relationships.
Hallucination of closed repeat proteins containing central pockets
Authors: An Linna , Hicks Derrick R. , Zorine Dmitri , Dauparas Justas , Wicky Basile I. M. , Milles Lukas F. , Courbet Alexis , Bera Asim K. , Nguyen Hannah , Kang Alex , Carter Lauren , Baker David 
Published: September 2023

AbstractIn pseudocyclic proteins, such as TIM barrels, β barrels, and some helical transmembrane channels, a single subunit is repeated in a cyclic pattern, giving rise to a central cavity that can serve as a pocket for ligand binding or enzymatic activity. Inspired by these proteins, we devised a deep-learning-based approach to broadly exploring the space of closed repeat proteins starting from only a specification of the repeat number and length. Biophysical data for 38 structurally diverse pseudocyclic designs produced in Escherichia coli are consistent with the design models, and the three crystal structures we were able to obtain are very close to the designed structures. Docking studies suggest the diversity of folds and central pockets provide effective starting points for designing small-molecule binders and enzymes.
A Higher radix architecture for quantum carry-lookahead adder
Authors: Wang Siyi , Baksi Anubhab , Chattopadhyay Anupam 
Published: September 2023

AbstractIn this paper, we propose an efficient quantum carry-lookahead adder based on the higher radix structure. For the addition of two n-bit numbers, our adder uses $$O(n)-O(\frac{n}{r})$$

O

(
n
)

-
O

(

n
r

)

qubits and $$O(n)+O(\frac{n}{r})$$

O

(
n
)

+
O

(

n
r

)

T gates to get the correct answer in T-depth $$O(r)+O(\log {\frac{n}{r}})$$

O

(
r
)

+
O

(
log

n
r

)

, where r is the radix. Quantum carry-lookahead adder has already attracted some attention because of its low T-depth. Our work further reduces the overall cost by introducing a higher radix layer. By analyzing the performance in T-depth, T-count, and qubit count, it is shown that the proposed adder is superior to existing quantum carry-lookahead adders. Even compared to the Draper out-of-place adder which is very compact and efficient, our adder is still better in terms of T-count.
Effect of vehicle external acceleration signal light on pedestrian-vehicle interaction
Authors: Li Feng , Pan Wenjun , Xiang Jiali 
Published: September 2023

AbstractThe number of casualties resulting from collisions between pedestrians and motor vehicles continues to rise. A significant factor is the misunderstanding of vehicle behavior intentions by pedestrians. This is especially true with the continuous development of vehicle automation technology, which has reduced direct interaction between drivers and the outside world. Therefore, accurate communication of vehicle behavior intentions is becoming increasingly important. The purpose of this study is to investigate the impact of external vehicle acceleration signal light on the interaction experience between pedestrians and vehicles. The differences between the use and nonuse of acceleration signal light are compared through controlled test track experiments in real scenarios and in videos.The results show that acceleration signal light help pedestrians understand vehicle behavior intentions more quickly and make safer crossing decisions as well as improving their perception of safety when crossing the street and their trust in vehicle behavior.
Picosecond to microsecond dynamics of X-ray irradiated materials at MHz pulse repetition rate
Authors: Lipp Vladimir , Grünert Jan , Liu Jia , Ziaja Beata 
Published: September 2023

AbstractModern X-ray free-electron lasers (XFELs) produce intense femtosecond X-ray pulses able to cause significant damage to irradiated targets. Energetic photoelectrons created upon X-ray absorption, and Auger electrons emitted after relaxation of core-hole states trigger secondary electron cascades, which contribute to the increasing transient free electron density on femtosecond timescales. Further evolution may involve energy and particle diffusion, creation of point defects, and lattice heating. This long-timescale (up to a microsecond) X-ray-induced dynamics is discussed on the example of silicon in two-dimensional geometry. For modeling, we apply an extended Two-Temperature model with electron density dynamics, nTTM, which describes relaxation of an irradiated sample between two successive X-ray pulses, emitted from XFEL at MHz pulse repetition rate. It takes into account ambipolar carrier diffusion, electronic and atomic heat conduction, as well as electron-ion coupling. To solve the nTTM system of equations in two dimensions, we developed a dedicated finite-difference integration algorithm based on Alternating Direction Implicit method with an additional predictor-corrector scheme. We show first results obtained with the model and discuss its possible applications for XFEL optics, detectors, and for diagnostics tools. In particular, the model can estimate the timescale of material relaxation relevant for beam diagnostic applications during MHz operation of contemporary and future XFELs.
Floating wind turbines structural details fatigue life assessment
Authors: Gaidai Oleg , Yakimov Vladimir , Wang Fang , Zhang Fuxi , Balakrishna Rajiv 
Published: September 2023

AbstractFatigue damage prediction is essential for safety of contemporary offshore energy industrial projects, like offshore wind turbines, that are to be designed for sufficiently long operational period of time, with minimal operational disruptions. Offshore structures being designed to withstand environmental loadings due to winds and waves. Due to accumulated fatigue damage, offshore wind floating turbines may develop material cracks in their critical locations sooner than expected. Dataset needed for an accurate assessment of fatigue damage may be produced by either extensive numerical modeling, or direct measurements. However, in reality, temporal length of the underlying dataset being typically too short to provide an accurate calculation of direct fatigue damage and fatigue life. Hence, the objective of this work is to contribute to the development of novel fatigue assessment methods, making better use of limited underlying dataset. In this study, in-situ environmental conditions were incorporated to assess offshore FWT tower base stresses; then structural cumulative fatigue damage has been assessed. Novel deconvolution extrapolation method has been introduced in this study, and it was shown to be able to accurately predict long-term fatigue damage. The latter technique was validated, using artificially reduced dataset, and resulted in fatigue damage that was shown to be close to the damage, calculated from the full original underlying dataset. Recommended method has been shown to utilize available dataset much more efficiently, compared to direct fatigue estimation. Accurate fatigue assessment of offshore wind turbine structural characteristics is essential for structural reliability, design, and operational safety.
Epitaxial van der Waals contacts of 2D TaSe2-WSe2 metal–semiconductor heterostructures
Authors: Qiao Peiyu , Xia Jing , Li Xuanze , Li Yuye , Cao Jianyu , zhang zhongshi , Lu Heng , Meng Qing , Li Jiangtao , Meng Xiang-Min 
Published: September 2023

Two-Dimensional TaSe2-WSe2 metal-semiconductor heterostructures have been successfully synthesized. The clean contact interface greatly improves the electronic contact performance.
Digital calibration technique based AC injection for continuous‐time sigma‐delta converters
Authors: Zhu Shengling , Chen Lei , Su Jie 
Published: September 2023

AbstractIn this study, a digital calibration method applicable for a continuous‐time sigma‐delta analogue‐to‐digital converter is proposed using the AC injection technique. The proposed technique directly calibrates the integration accuracy of a converter instead of only trimming the capacitors. Compared with the existing calibration methods, the proposed method does not require complex timing logic processing or additional capacitors and does not adversely impact the dynamic performance of the converter. Furthermore, it ensures the accuracy of the converter, regardless of the non‐ideal effects of advanced processes.
Maritime moving target detection and localisation technique for Global Navigation Satellite Signals‐based passive multistatic radar
Authors: Nasso Ilaria , Santi Fabrizio 
Published: September 2023

AbstractThis article puts forward a ship target detection and localisation technique for GNSS‐based passive multistatic radar. The approach capitalises on the large spatial diversity offered by navigation satellite constellations to provide maritime awareness using short integration time windows, thus bypassing the shortcomings suffered by approaches relying on long dwells typically considered in satellite‐based passive radar systems. The proposed approach entirely operates on the Cartesian plane and it is able to provide in a single stage the detection and localisation of the target in the surveyed area. Theoretical and simulated performance analysis are provided to illustrate as the proposed approach can outperform conventional two‐stages (i.e. bistatic detection then localisation) procedures, with particular regard to the case of significant radar cross section scintillation, likely experienced in the system under consideration. The effectiveness of the approach has been verified via experimental data acquired in a few scenarios of interest comprising opportunistic targets belonging to different types.
Global Navigation Satellite Systems disciplined oscillator synchronisation of multistatic radar
Authors: Beasley Piers J. , Peters Nial , Horne Colin , Ritchie Matthew A. 
Published: September 2023

AbstractA fundamental challenge in the practical implementation of multistatic radar systems (MSRS) is the requirement for precise time and frequency synchronisation between the spatially separated radar nodes. The authors evaluate the performance of different classes of commercially available Global Navigation Satellite Systems (GNSS) timing receivers, Local Oscillators (LO) and GNSS Disciplined Oscillators (GNSSDOs) to determine the limitations of using one‐way GNSS Time and Frequency Transfer (TFT) in this application. From evaluating the performance of three pairs of GNSSDOs, it is concluded that one‐way GNSS TFT will likely be suitable only for the synchronisation of fully spatially coherent MSRS with carrier frequencies up to 100 MHz and waveform bandwidths up to 20 MHz. Whereas, in the case of short‐term spatially coherent MSRS, synchronisation of systems with carrier frequencies up to a few GHz and waveform bandwidths of over 100 MHz will likely be possible. The performance of the different classes of GNSSDOs during GNSS denial (holdover) are evaluated, where it is concluded that frequency offsets between LOs at the point of GNSS denial will often significantly contribute, or even dominate, the holdover performance. Analysis of two practical multistatic radar measurements verifies the function of using the GNSSDOs for wireless synchronisation of the ARESTOR MSRS.
Neonatal Hypoglycemia following Late Preterm Antenatal Corticosteroid Administration in Individuals with Diabetes in Pregnancy
Authors: Raj-Derouin Natasha , Perino John M. , Fisher Sophie , Zhang Yijia , Thaker Vidhu , Zork Noelia M. 
Published: September 2023

Objective Antenatal corticosteroid (ACS) administration is standard practice for pregnant individuals delivering in the late preterm period, though no guidelines are in place for those with diabetes. This study aims to characterize the prevalence of neonatal hypoglycemia after ACS administration in pregnant individuals with diabetes delivering in the late preterm period.
Study Design This is a retrospective, single-center, case–control study of individuals with diabetes who delivered between 340/7 and 366/7 weeks' gestation at a large academic medical center from 2016 to 2021. A total of 169 individuals were included in the analysis; 87 received corticosteroids and 82 did not. The proportion of neonates with hypoglycemia, neonatal intensive care unit (NICU) admission, respiratory distress syndrome, and hyperbilirubinemia were compared between parents who received ACSs versus those who did not.
Results The prevalence of neonatal hypoglycemia (40.2 vs. 23.2%, p = 0.027), requiring treatment (40.3 vs. 22.4%, p = 0.041), and hyperbilirubinemia (35.6 vs 18.5%, p = 0.018) was greater for neonates born to individuals with diabetes who received late preterm ACSs compared with those who did not. There was no difference in NICU admission and respiratory distress between the groups. These results remained unchanged after controlling for confounders including gestational age at delivery and birth weight.
Conclusion This study demonstrates that late preterm corticosteroid administration to pregnant individuals with diabetes increases the risk for neonatal hypoglycemia without changing the rates of respiratory morbidity.
Key Points
Cold snare defect protrusion and incomplete polyp resection after forced cold snare polypectomy: a prospective observational study
Authors: Arimoto Jun , Chiba Hideyuki , Yamada Keiji , Nishiguchi Takanori , Kobayashi Mikio , Okada Naoya , Suto Takuma , Niikura Toshihiro , Kuwabara Hiroki , Nakaoka Michiko , Ida Tomonori 
Published: September 2023

Abstract
Background Cold snare defect protrusions (CSDPs) that occur after cold snare polypectomy (CSP) are considered indicators of incomplete polyp resection (IPR). We have sometimes experienced difficulty resecting polyps with snaring alone; in such cases, a forcible pull on the snare by the endoscopist is necessary. We call this procedure “forced CSP (FCSP).” However, no previous studies have evaluated this procedure.

Methods This was a prospective observational study. From November 2020 to June 2021, the frequency, safety, and validity of FCSP were evaluated at our hospital. We distinguished CSP with snaring alone performed by the assistant as conventional CSP, and CSP requiring a forcible pull on the snare by the endoscopist as FCSP.
Results Of 1315 polyps removed, 105 underwent FCSP (8%). The perforation rate was 0% in both groups. The rate of CSDP after the procedure was 96.2% (101/105) with FCSP and 6.4% (77/1210) with conventional CSP (P<0.001). The rate of IPR was 12.5% (13/104) with FCSP and 6.2% (75/1208) with conventional CSP (P=0.02). Multivariable analysis identified polyps located in the cecum (risk ratio [RR], 1.13; 95%CI 1.050–1.179; P=0.003) and polyps ≥6mm in diameter (RR, 2.37; 95%CI 2.146–2.542; P<0.001) as independent risk factors for FCSP.
Conclusions FCSP was performed on 105 polyps (8%) in this study. FCSP may be associated with the occurrence of CSDP and IPR. Further studies are necessary to confirm our results.
Profiling consumers who reported mass marketing scams: demographic characteristics and emotional sentiments associated with victimization
Authors: DeLiema Marguerite , Witt Paul 
Published: September 2023

AbstractWe examine the characteristics of consumers who reported scams to the U.S. Federal Trade Commission. We assess how consumers vary demographically across six scam types, and how the overall emotional sentiment of a consumer’s complaint (positive, negative, neutral/mixed) relates to reporting victimization versus attempted fraud (no losses). For romance, tech support, and prize, sweepstakes, and lottery scams, more older than young and middle-aged adults reported victimization. Across all scam types, consumers classified as Black, Hispanic, and Asian/Asian Pacific Islander were more likely than non-Hispanic white consumers to report victimization than attempted fraud. Relative to complaints categorized as emotionally neutral or mixed, we find that emotionally positive complaints and emotionally negative complaints were significantly associated with victimization, but that these relationships differed by scam type. This study helps identify which consumer groups are affected by specific scams and the association between emotion and victimization.