bluuebunny/crossref_metadata_2025_split huggingface dataset:
The Therapeutic Effects of Bromelain against Colorectal Cancer: A
Systematic Review
Authors: Forootan Mojgan , Amiri Mehdi Mohammadian , Darvishi Mohammad , Sherwin Catherine M.T. , Ghanadi Koruosh 
Published: October 2023

Background:
Colorectal cancer (CRC) is one of the most prevalent cancers worldwide.

Objective:
Considering the side effects of chemotherapy treatments, we reviewed the anti-cancer effects
and mechanisms of bromelain on colon cancer cells in this study.

Methods:
The PRISMA guidelines were followed in the design of this systematic review. Various
databases, including PubMed, Web of Science, Cochrane Library, and Scopus, were thoroughly
searched. Finally, 14 articles were retrieved after considering the study's inclusion and exclusion criteria.
The desired data were extracted, entered into an Excel file, and the study results were reviewed.

Results:
According to the included studies, bromelain can significantly reduce the survival and death
of cloned cancer cells through different mechanisms. These mechanisms include impeding tumor
growth and metastasis by reducing mucins production/secretion and increasing/reducing reactive oxygen
species (ROS) production. Moreover, bromelain induces apoptosis via reduced expression of
Bcl-2, extracellular signal-related kinase (ERK), Akt, activation caspase system (caspase-3, 7, 8, and
9), and extranuclear p53. Ferroptosis was another mechanism of causing cell death. In addition, bromelain
activates the autophagy pathway, lysosome formation, and deregulation of other autophagyrelated
proteins.

Conclusion:
Bromelain effectively inhibits colon cancer cells' growth, proliferation, and metastasis
and reduces their survival by different mechanisms. Therefore, after examining clinical studies, it can
be used as an effective drug for treating CRC.
Streptomyces Paradigm in Anticancer Therapy: A State-of-the Art Review
Authors: Sethi Yashendra , Vora Vidhi , Anyagwa Onyekachi Emmanuel , Turabi Nafisa , Abdelwahab Maya , Kaiwan Oroshay , Chopra Hitesh , Attia Mohamed Shah , Yahya Galal , Emran Talha Bin , Padda Inderbir 
Published: October 2023

Abstract:
Cancer is one of the biggest threats to human health with a global incidence of 23.6 million,
mortality of 10 million, and an estimated 250 million lost in disability-adjusted life years
(DALYs) each year. Moreover, the incidence, mortality, and DALYs have increased over the past
decade by 26.3%, 20.9%, and 16.0%, respectively. Despite significant evolutions in medical therapy
and advances in the DNA microarray, proteomics technology, and targeted therapies, anticancer drug
resistance continues to be a growing concern and invites regular discovery of potent agents. One such
agent is the microbe-producing bioactive compounds like Streptomyces, which are proving increasingly
resourceful in anticancer therapy of the future. Streptomyces, especially the species living in
extreme conditions, produce bioactive compounds with cytolytic and anti-oxidative activity which
can be utilized for producing anticancer and chemo-preventive agents. The efficacy of the derived
compounds has been proven on cell lines and some of these have already established clinical results.
These compounds can potentially be utilized in the treatment of a variety of cancers including but not
limited to colon, lung, breast, GI tract, cervix, and skin cancer. The Streptomyces, thus possess the
armory to fuel the anticancer agents of the future and help address the problem of rising resistance to
currently available anti-cancer drugs. We conducted a state-of-art review using electronic databases
of PubMed, Scopus, and Google scholar with an objective to appraise the currently available literature
on Streptomyces as a source of anti-cancer agents and to compile the clinically significant literature
to update the clinicians.
Essential Fatty Acids along the Women’s Life Cycle and Promotion of a
Well-balanced Metabolism
Authors: Marchiori Georgina N. , Eynard Aldo R. , Soria Elio A. 
Published: October 2023

Abstract:
Linoleic acid (ω-6 LA) and α-linolenic acid (ω-3 ALA) are essential fatty acids (EFA)
for human beings. They must be consumed through diet and then extensively metabolized, a process that plays a fundamental role in health and eventually in disease prevention. Given the numerous changes depending on age and sex, EFA metabolic adaptations require further investigations
along the women’s life cycle, from onset to decline of the reproductive age. Thus, this review explains women’s life cycle stages and their involvement in diet intake, digestion and absorption,
the role of microbiota, metabolism, bioavailability, and EFA fate and major metabolites. This
knowledge is crucial to promoting lipid homeostasis according to female physiology through well-directed health strategies. Concerning this, the promotion of breastfeeding, nutrition, and physical activity is cardinal to counteract ALA deficiency, LA/ALA imbalance, and the release of unhealthy derivatives. These perturbations arise after menopause that compromise both lipogenic
and lipolytic pathways. The close interplay of diet, age, female organism, and microbiota also
plays a central role in regulating lipid metabolism. Consequently, future studies are encouraged to
propose efficient interventions for each stage of women's cycle. In this sense, plant-derived foods
and products are promising to be included in women’s nutrition to improve EFA metabolism.
Comparison of the Effects of Sanyinjiao Point (SP6) Acupressure with
Combined SP6 and LI4 Acupressure on Labor Pain Intensity in
Primiparous Women: A Randomized Controlled Trial
Authors: Ghiasi Ashraf , Sharaflari Fatemeh , Bagheri Leila 
Published: October 2023

Background:
Childbirth is an important event and special experience in women's lives.
Labor pain is the most severe pain that women undergo in their lives. Pain management during labor is crucial for the well-being of the mother and fetus.

Objective:
This study aimed to compare the effect of combined LI4 and SP6 acupressure with SP6
acupressure on reducing labor pain.

Methods:
A total of 108 primiparous women who participated in the study were randomized into
three groups, combining LI4 and SP6 acupressure, SP6 acupressure, and a control group. Pain intensity was evaluated before, immediately, 1 and 2 hours after the intervention and the second
stage of labor by visual analogue scale (VAS).

Results:
Although the pain intensity immediately after the intervention was lower in the combined
SP6 and LI4 acupressure group than in the other groups, the differences were not significant between the three groups (p = 0.147). The pain intensity 1 hour after the intervention and in the second stage of labor had a statistically significant difference between the three groups (p =0.006, p
=0.001). The pain intensity 2 hours after the intervention was lower in the combined SP6 and LI4
acupressure group than the other groups, but it was not statistically significantly different (p=
0.05). The pain intensity 1 hour after the intervention was not statistically different between the
SP6 group and the control group (p= 0.095). The pain intensity 2 hours after the intervention was
lower in the combined SP6 and LI4 acupressure group compared to the control group, but it was
not significant (p=0.06). The pain intensity in the second stage of labor was lower in the combined
SP6 and LI4 acupressure group and SP6 acupressure group compared to the control group (p
=0.001, p = 0.017), but there was no significant difference between the SP6 acupressure group
and combined SP6 and LI4 acupressure group (p=1.000).

Conclusion:
The obtained results revealed that combination intervention is a safe, effective, noninvasive and economical method in alleviating labor pain intensity. Healthcare providers are expected to master the acupressure technique as an alternative, complementary therapy, which can
be used as an alternative or additional therapy.
Molecular Modelling of Resveratrol Derivatives with SIRT1 for the
Stimulation of Deacetylase Activity
Authors: Zamani Mozhdeh , Mokarram Pooneh , Jamshidi Mehdi , Siri Morvarid , Ghasemi Hadi 
Published: October 2023

Background:
Resveratrol is a polyphenol that is found in plants and has been proposed
to have a potential therapeutic effect through the activation of SIRT1, which is a crucial
member of the mammalian NAD+ -dependent deacetylases. However, how its activity is enhanced
toward specific substrates by resveratrol derivatives has not been studied. This study
aimed to evaluate the types of interaction of resveratrol and its derivatives with SIRT1 as the
target protein, as well as to find out the best ligand with the strangest interaction with SIRT1.

Materials and Methods:
In this study, we employed the extensive molecular docking analysis
using AutoDock Vina to comparatively evaluate the interactions of resveratrol derivatives (22
molecules from the ZINC database) as ligands with SIRT1 (PDB ID: 5BTR) as a receptor. The
ChemDraw and Chem3D tools were used to prepare 3D structures of all ligands and energetically
minimize them by the MM2 force field.

Results:
The molecular docking and visualizations showed that conformational change in
resveratrol derivatives significantly influenced the parameter for docking results. Several types
of interactions, including conventional hydrogen bonds, carbon-hydrogen bonds, Pi-donor hydrogen
bonds, and Pi-Alkyl, were found via docking analysis of resveratrol derivatives and
SIRT1 receptors. The possible activation effect of resveratrol 4'-(6-galloylglucoside) with ZINC
ID: ZINC230079516 with higher binding energy score (-46.8608 kJ/mol) to the catalytic domain
(CD) of SIRT1 was achieved at the maximum value for SIRT1, as compared to resveratrol
and its other derivatives.

Conclusion:
Finally, resveratrol 4'-(6-galloylglucoside), as a derivative for resveratrol, has stably
interacted with the CD of SIRT1 and might be a potential effective activator for SIRT1.
Analytical Methods for Triamcinolone Acetonide: An Exploratory
Literature Review
Authors: Gulati Diksha , Saini Aakriti , Dhingra Ashwani K. 
Published: October 2023

Abstract:
An artificial glucocorticoid with anti-inflammatory and immunosuppressive properties is triamcinolone acetonide. It is abundantly used to treat redness, itching, and many other skin condi-tions like itching and psoriasis. As a result, there are several different triamcinolone acetonide for-mulations available. Each of these formulations must go through the correct phases of development and validation in order to identify the medications and other additives for safer use. This review article is just a representation of all the methods reported for the development and validation of triamcinolone acetonide in pure form to break down contaminants, in addition to other medications, and even in biological samples. The International Council for Harmonization (ICH) technical re-quirements for human use suggestions, which include a number of analytical parameters, have been followed in the validation of all the procedures. The present study also clarified the most significant drug combination.
Obesity Phenotypes and Dental Calculus in Young Adults: CHIEF Oral
Health Study
Authors: Liu Wei-Nung , Huang Ren-Yeong , Cheng Wan-Chien , Wang Hui-Shang , Huang Chen-Ming , Chen Han-Hsing , Tsai Kun-Zhe , Lin Gen-Min 
Published: October 2023

Aim:
The study aimed to examine the association of obesity phenotypes with dental
calculus.

Background:
Obesity has been recognized as a risk factor for kidney and gallbladder stones
formation and periodontitis.

Objective:
We have investigated the association between obesity, metabolic risk factors, and
dental calculus, which is a sequela following periodontitis

Methods:
This study included 5,281 military members, aged 19–45 years, without antihypertensive
medications in Taiwan. Obesity was defined as body mass index ≥27.5 kg/m2, and
metabolic syndrome (MetS) was defined according to the modified ATP III criteria. Supragingival
calculus in any teeth, except for impacted teeth and the third molar, was the outcome of
interest. Multiple linear regression analysis with adjustments for age, sex, toxic substance use,
brushing teeth frequency, and blood leukocyte counts, was used to determine the association of
obesity with dental calculus numbers. Multiple logistic regression analysis was used to assess
the association between obesity with or without MetS and the presence of any dental calculus.

Results:
BMI was positively correlated to dental calculus numbers [β and confidence intervals
(CI) = 0.023 (0.014, 0.032)]. Compared to the obesity(-)/MetS(-) group, there were dosedependent
associations for the obesity(-)/MetS(+), obesity(+)/MetS(-), and obesity(+)/MetS(+)
groups with the presence of any dental calculus [odds ratios (ORs): 1.08 (0.76, 1.53), 1.31 (1.08,
1.58), and 1.51 (1.20, 1.90), respectively]. Of the metabolic risk factors, abdominal obesity and
hypertension were independently associated with dental calculus [ORs: 1.33 (1.13, 1.55) and
1.30 (1.11, 1.52), respectively].

Conclusion:
This study suggests general obesity as an independent risk factor for dental calculus
formation, and MetS, particularly the components of abdominal obesity, and hypertension
may also increase the prevalence of dental calculus. Diet control and regular exercise might be
preventive measures for the development of both obesity and dental calculus.
Monkey Pox: Virology, Epidemiology, Vaccines, and Therapeutic
Approaches
Authors: Geevarghese Abin V. 
Published: October 2023

Abstract:
The monkeypox virus, which was historically common in West and Central Africa,
is the source of the zoonotic disease known as monkeypox. Instances, however, have recently
been confirmed in a few non-endemic nations outside of Africa. In light of the COVID-19 pandemic, the WHO labeled the current monkeypox epidemic a public health emergency of global
concern on July 23, 2022. The international society may be in jeopardy due to the rapidly increasing number of confirmed cases. Current epidemiological statistics indicate that the high
frequency of transmission from person to person might result in additional epidemics, especially
among guys who have sex with males. Despite certain therapeutic benefits of already prescribed
pharmaceuticals, there is an urgent need for the creation of antiviral therapies and vaccinations
to ward off the monkeypox virus. We offer pertinent information to help people understand the
monkeypox virus and help medical professionals in stopping the spread of the monkeypox virus.
AI-based Controllers for a Z-Axis Micro Precision Positioning System
Authors: Abdi Ali 
Published: October 2023

Background:
Stick-slip actuators are commonly used in Nano/Micro precision positioning
systems, but their control is challenging due to factors like nonlinear friction, PEA hysteresis, and uncertainty. Researchers have made efforts to address these challenges and documented their findings in
articles and patents.

Methods:
This study introduces a novel vertical stick-slip actuator and proposes two different methods
for overcoming the challenges associated with controlling it. The first method involves training an inverse model of the actuator using a supervised machine-learning algorithm to determine the optimal
number of signals and peak voltage required for the saw-tooth signals in an open-loop controller. The
second method is a closed-loop controller that utilizes the maximum allowable peak voltage unless the
positioning error is smaller than the maximum step size. At this point, the neural network-based controller adjusts the peak voltage to a lower value, ensuring that the actuator reaches the desired position
at the end of the final signal.

Results:
According to the results, both controllers perform effectively. The open-loop and closed-loop
controllers exhibit a relative error of 1.59% and 0.4%, respectively, for an arbitrary desired position in
the final position.

Conclusion:
In conclusion, the suggested controllers offer a practical solution to the controlling challenges faced by stick-slip positioners, which are essential in the advancement of Nano/Micro sciences.
Standardization of Herbal Medicines and the Guidelines for the
Standardization
Authors: Ahire Tejas , Gosavi Seema , Sonawane Saurabh , Chaudhari Riya , Bornare Pratiksha 
Published: October 2023

Abstract:
The use of medicinal plants for their therapeutic benefits is immemorial, leading to their
global acceptability. The pharmaceutical market is significantly influenced by medicinal plants and
herbal preparations as a source for pharmaceutical manufacturing procedures. Over the past few
decades, the mass production of herbal preparations at an industrial scale as well as the adulteration
of raw material and final products have raised serious concerns over its safety, purity, and efficacy.
Standardization of medicinal plants and their preparations as per the current WHO guidelines is of
prime importance to overcome quality issues. The guidelines aim at the identification of potentially
hazardous contaminants and assessing the quality of the herbal material by various qualitative and
quantitative means. Various methodologies, techniques, and procedures are prescribed in the guidelines for maintaining the overall quality of the finished herbal product. However, due to a lack of
research data and technical constraints many of the accepted limits in the guidelines are a reference
and extrapolation of research done in food science. Standardization is a crucial part of the quality
assurance program so as to set proper norms for the manufacture of quality products thus contributing to the benefit of mankind. The current review aims at highlighting various standardization
parameters and guidelines for the same.
A Narrative Review on Effects of Napier Grass Oxalate Accumulation on
Ruminant Animals
Authors: Choudhury Md. Panir , Hossain S. M. Jahangir , Akter Shahrina , Islam Md. Tasmirul , Khadija-Tut-Tahira  
Published: October 2023

Abstract::
Napier grass is a popular ruminant feed due to its nutritional value and ease of propagation.
Besides these promising characteristics, Napier grass poisoning has been reported in livestock,
and oxalate has been identified as a primary toxin. Oxalate is an antinutrient content that prevents
absorption of minerals from plants while grazing by animals. Less than 2.0% of ruminants' soluble
oxalate of dry matter (DM) consumption is safe, while 0.5% is safe for non-ruminants. Oxalate
buildup varies with nitrogen sources and dosages. This review discusses the impacts of external and
internal elements, including fodder species/variety, fodder portions, seasonal change, nitrogen fertilization,
clipping interval, and oxalate concentration on grazing animals and management measures
to reduce fodder oxalate. However, further research is needed to understand how oxalate in different
species interacts with grazing animals. For developing oxalate-free fodder genotypes, molecular
techniques, including identification of CRISPR/Cas9, QTLs, and functional genomics, may be helpful.
Genomic methods to improve Napier grass employing precision phenotyping, genotyping, and
molecular technology have also been discussed in this article. We have discussed the metabolic pathway,
digestion in ruminant animals, factors affecting oxalate content, genetic and molecular diversity,
oxalate impact and poisoning, disease to Napier grass and future prospects. This may be helpful
for the researchers working on ruminant animals for their feeds and fodder.
Instrument development to measure the use of hologram-based learning media
Authors: Vebrianto Rian , Yusriadi M , Yuliastrin Adisti 
Published: October 2023

Hologram-based learning media is one of the alternative learning media that can be used as educational media, increasing student motivation and interest in learning and optimizing the division of work in groups. This media was developed to avoid abstract thinking, a negative impression that has been allowed to occur since they were young, which, in the end, until adulthood, the negative image is dull and makes students uninterested in things. This research was included as developmental research or RnD. Studies related to developing instruments to measure the use of hologram-based learning media as educational media in elementary schools still need to be completed. The research model used in this study was 4D. The data was collected with an offline questionnaire, and then it was analyzed using quantitative data analysis using the SPSS version 23 for Windows program. The results of this study have proven that: (1) The evaluation instruments construction and development for the use of hologram-based learning media for students in this study were carried out using a theoretical development model to test seven research constructs, namely (a) didactic components, (b) construction of hologram-based learning media, (c) technical hologram-based learning media, (d) ease of use, (e) efficiency of hologram-based learning media, (f) benefits, and (g) interest; (2) The results of construct validity and reliability testing show that the validity of the evaluation instrument has met the valid criteria because the value of r-count r-table (r-count 0.254); and (3) The reliability of the evaluation instrument which has been compiled and developed in this study has also met the high category as indicated by the magnitude of the Cronbach alpha reliability coefficient of 0.980. This indicates that the instrument developed meets the requirements for measuring the use of hologram-based learning media for students.
Sundanese ethnoastronomy-based astronomy bulletin as an alternative to astronomy learning: A feasibility test
Authors: Husna Salsabila , Diyana Tsania Nur 
Published: October 2023

This study aims to determine the feasibility of independently developing a Sundanese ethnoastronomy-based astronomy bulletin as an alternative astronomical learning media. This research uses the ADDIE method, which consists of five stages, namely (1) Analysis, (2) Design, (3) Development, (4) Implementation (5) Evaluation. However, this research only reached the determination of the feasibility of the bulletin, so the implementation and evaluation stages still needed to be carried out. The subjects of this study were one physics education lecturer and one physics teacher. The results of the feasibility test on the three indicators include (1) content validation tests obtained an average value of 81.25%, (2) language validation tests obtained an average value of 81.25%, and (3) presentation validation tests obtained a value of 80%, and the overall indicators showed reliable results. Therefore, the bulletin learning media developed is feasible and can be used as an alternative learning media for Sundanese ethnoastronomy-based astronomy.