bluuebunny/crossref_metadata_2025_split huggingface dataset:
A case of bleeding shock induced by injury of the intercostal artery following percutaneous nephrolithotripsy
Authors: Kakinoki Hiroaki , Yamaguchi Yukako , Yukimoto Minika , Kakinoki Yuka , Udo Kazuma , Tobu Shohei , Takeshita Go , Egashira Yoshiaki , Yamaguchi Ken , Noguchi Mitsuru 
Published: October 2023

IntroductionThe risk of postoperative bleeding complications should be concerned to perform percutaneous nephrolithotripsy. Most of the vascular injuries occurred at the peripheral renal artery in the previous reports. We experienced a case of bleeding shock induced by the injury of the intercostal artery in the abdominal wall following percutaneous nephrolithotripsy.Case presentationA 56‐year‐old woman had been in the bleeding shock status on the 2nd day after percutaneous nephrolithotoripsy. Emergently, contrast‐enhanced computed tomography was performed and extravasation of contrast agents was seen in the abdominal wall. Injuries of the intercostal artery were identified in the angiography and controlled by transcatheter arterial embolization.ConclusionThe intercostal arteries could be injured in the anterolateral zone of the abdominal wall over the end of the ribs. Contrast‐enhanced computed tomography was useful to detect the bleeding point. Transcatheter arterial embolization was an effective and safe method to control bleedings from them.
Both sides of irrigation management: An empirical analysis of smallholders' perception of co‐management of irrigation systems
Authors: Salman Maher , Fertő Imre , Pek Eva 
Published: October 2023

AbstractGrowing water imbalance requires a systematic development process to enable the agriculture sector to address what it faces as challenges. However, the overall longevity and efficiency of developed infrastructure become doubtful if water users are not involved in the development process. Thus, the assessment of the impact of irrigation improvement on all sides of the management, including smallholders, is fundamental. The paper investigates the impact of irrigation improvement on farmers' satisfaction with transferred water services in the Old Lands in Egypt. A counterfactual analysis, relying on four alternative estimation methods, is introduced to measure the average treatment effect of irrigation improvement on farmers' perceptions of reliability, flexibility and equity of the water service. Such indicators' selection was planned under the assumption that combined social and engineering‐based approaches to impact assessments are more suitable to represent the perspectives of all stakeholders. The results of the analysis are consistent and show that increases in perceptions are positive and significant in each case, as the result of the improvement. The paper argues that modern infrastructure framed in successful co‐management can work towards a mutual interest.
Bioequivalence of Soft Gelatin Capsules and Oral Solution of a New Cyclosporine Formulation
Authors: Kovarik John M. , Mueller Edgar A. , Johnston Atholl , Hitzenberger Gerhart , Kutz Klaus 
Published: October 2023

Study Objective. To compare the bioavailability of cyclosporine from two oral dosage forms of a new microemulsion formulation.Design. Open, randomized, three‐treatment, three‐period crossover investigation.Setting. University‐affiliated clinical pharmacology research unit.Patients. Twenty‐four healthy male volunteers.Interventions. Single oral administrations of cyclosporine 180 mg given as a soft gelatin capsule (reference), an oral solution under fasting conditions, and the oral solution mixed with orange juice.Measurements and Main Results. Serial venous blood samples were obtained over 48 hours after each administration to measure cyclosporine in whole blood by a specific monoclonal radioimmunoassay. For all three treatments, the mean maximum blood concentration (Cmax) of approximately 1100 ng/ml was reached at about 1.3 hours (tmax) after administration; the area under the blood concentration‐time curve (AUC) was, on average, 4700 ng·hr/ml. Bioequivalence was conclusively demonstrated for both the absorption rate (Cmax and tmax) and extent (AUC) of cyclosporine among the treatments inasmuch as the point estimates and 90% confidence intervals were within the respective equivalence ranges.Conclusions. When administered in conjunction with routine concentration monitoring, the two oral dosage forms of the new microemulsion formulation of cyclosporine can be interchanged without need for dosage adjustments. In addition, the oral solution can be mixed with fruit juice without affecting the rate or extent of cyclosporine absorption.
Rat Tumor Leydig Cells as a Test System for the Study of Sertoli Cell Factors That Stimulate Steroidogenesis
Authors: VERHOEVEN GUIDO , CAILLEAU JEAN 
Published: October 2023

AbstractTransplantable rat Leydig cell tumor H‐540 was used to study the interactions between Leydig and Sertoli cells. These tumor cells maintain their steroidogenic capacity when cultured. Their responsiveness to a number of agonists that affect normal Leydig cells is markedly changed. Steroidogenesis can no longer be stimulated by luteinizing hormone (LH), but the cells remain responsive to dibutyrylcyclic adenosine monophosphate (dbcAMP) and cholera toxin. Cultured cells mainly produce C21‐steroids, but the ability to produce androgens can be restored by pretreatment with dbcAMP. Coculture with Sertoli cells increases steroidogenesis in H‐540 cells, and this effect is enhanced by follicle‐stimulating hormone (FSH). Experiments with a two‐chamber culture system show that these effects are mediated by one or more diffusible factors, some of which may be short‐acting. SCF, a Sertoli cell‐derived factor that stimulates normal Leydig cells, is not the mediator in this system since it is unable to stimulate steroidogenesis in Leydig tumor cells. Immunoneutralization experiments show that insulin‐like growth factor I (IGF‐I) is a permissive factor required to maintain steroidogenesis in Leydig tumor monocultures and in cocultures with Sertoli cells, but addition of IGF‐I does not mimic the stimulatory effect of coculture. It was concluded that factors other than SCF and IGF‐I must be involved in the stimulatory effects of coculture, and that H‐540 cells may be a useful tool for the study of these factors.
Correlation of Sperm Motion Parameters with Fertility in Rats Treated Subchronically with Epichlorohydrin
Authors: TOTH G. P. , STOBER J. A. , ZENICK H. , READ E. J. , CHRIST S. A. , SMITH M. K. 
Published: October 2023

AbstractWe investigated the relationship between fertility and sperm motion endpoints in rats treated subchronically with the male reproductive toxicant, epichlorohydrin (ECH). Male rats were given ECH orally for 23 days at dosages of 0, 6.25, 12.5, or 25 mg/kg/day. They were mated twice (at 19 and 22 days) to estimate fertility by (1) detection of fertilized ova (presence of sperm head and tail or two pronuclei) 18 hours after mating and by (2) counting implants on day 14 of gestation. Both indices showed dose‐related reductions (P < 0.001). Motion parameters of cauda epididymal sperm were assessed using the CellSoft computer‐assisted sperm motion analysis (CASA) system after the rats were asphyxiated on day 25. Curvilinear velocity, straight‐line velocity, linearity, and amplitude of lateral head displacement were reduced in a dose‐related manner. The fertility indices, percent fertilized ova, and percent implantation on day 14 of gestation were correlated significantly (r = 0.68; P = 0.0001). The following motion parameters were also correlated significantly with fertility (P < 0.0003; r1 = percent fertilized ova and r2 = percent implantation): linearity (r1 = 0.42; r2 = 0.40), amplitude of lateral head displacement (r1 = 0.54; r2 = 0.48), curvilinear velocity (r1 = 0.53; r2 = 0.50), straight‐line velocity (r1 = 0.55; r2 = 0.50), and percent motile sperm (r1 = 0.42; r2 = 0.32). These results suggest a relationship between toxicant‐induced reductions in sperm motion and fertility.
Coenzyme Q10 Concentrations in Normal and Pathological Human Seminal Fluid
Authors: MANCINI ANTONIO , de MARINIS LAURA , ORADEI ALESSANDRO , HALLGASS MARIA ELENA , CONTE GIANLUIGI , POZZA DIEGO , LITTARRU GIAN PAOLO 
Published: October 2023

ABSTRACT: Coenzyme Q10 (CoQ10) levels were assayed in total seminal fluid or both in seminal fluid and seminal plasma in 77 subjects with normal or pathological findings at standard semen analysis. CoQ10 levels showed a significant correlation with sperm count and with sperm motility. An interesting exception was constituted by patients with varicocele, in whom the correlation with sperm concentration was preserved, whereas the correlation with sperm motility was lacking. Moreover, they showed an increased ratio of plasma CoQ to total seminal CoQ10 in comparison with the other subjects.These data suggest a pathophysiological meaning of CoQ10 in human seminal fluid and a possible molecular defect in varicocele patients. CoQ10 measurement could represent an important examination in infertile patients; moreover, from these results a rationale might arise for a possible treatment with exogenous CoQ10 in dyspermic patients.
The effects of icon updating on user visual discrimination under different working memory load
Authors: Chen Mo , Li Jing , Zhu Yanfei 
Published: October 2023

AbstractTo lessen users' feelings of unease and stress after icons are updated, this study investigates icon recognition and discrimination in terms of icon color and location under different working memory (WM) loads. At low WM load, changing the color or position of the icons has little effect on icon recognition. The icon color update will affect the user's accuracy when less information is presented, but it will not affect participants' reaction time. As for position updates, it is better to update icons' positions within the same row rather than across rows. At high WM load, although subjects responded faster to color than location, subjects were more accurate with location than with color. It can be concluded that color updates are preferred for entertaining user interfaces that demand quick responses, while location updates are preferable for human–computer interfaces that focus on accuracy. From the results of high WM load, subjects are more sensitive to color brightness. The more drastic the color difference, especially if the change level was at levels of 20% or 40%, the subjects' responses would be more obvious.
Non‐enzymatic glycation reduces glucose transport in the human cartilage endplate independently of matrix porosity or proteoglycan content
Authors: Jung Jae‐Young , Habib Mohamed , Morrissette Luke J. , Timmons Shannon C. , Maerz Tristan , Fields Aaron J. 
Published: October 2023

AbstractBackgroundIntervertebral disc degeneration is associated with low back pain, which is a leading cause of disability. While the precise causes of disc degeneration are unknown, inadequate nutrient and metabolite transport through the cartilage endplate (CEP) may be one important factor. Prior work shows that CEP transport properties depend on the porosity of the CEP matrix, but little is known about the role of CEP characteristics that could influence transport properties independently from porosity. Here, we show that CEP transport properties depend on the extent of non‐enzymatic glycation of the CEP matrix.Methods and ResultsUsing in vitro ribosylation to induce non‐enzymatic glycation and promote the formation of advanced glycation end products, we found that ribosylation reduced glucose partition coefficients in human cadaveric lumbar CEP tissues by 10.7%, on average, compared with donor‐ and site‐matched CEP tissues that did not undergo ribosylation (p = 0.04). These reductions in glucose uptake were observed in the absence of differences in CEP porosity (p = 0.89) or in the amounts of sulfated glycosaminoglycans (sGAGs, p = 0.47) or collagen (p = 0.61). To investigate whether ribosylation altered electrostatic interactions between fixed charges on the sGAG molecules and the mobile free ions, we measured the charge density in the CEP matrix using equilibrium partitioning of a cationic contrast agent using micro‐computed tomography. After contrast enhancement, mean X‐ray attenuation was 11.9% lower in the CEP tissues that had undergone ribosylation (p = 0.02), implying the CEP matrix was less negatively charged.ConclusionsTaken together, these findings indicate that non‐enzymatic glycation negatively impacts glucose transport in the CEP independent of matrix porosity or sGAG content and that the effects may be mediated by alterations to matrix charge density.
Study on ecological stoichiometry homeostasis characteristics of different halophytes in the Yellow River Delta
Authors: Zhao Yinghan , Li Tian , Sun Jingkuan , Liu Junhan , Fu Zhanyong 
Published: October 2023

AbstractEcological stoichiometric homeostasis represents the physiological and biochemical adaptations of organisms to variations in environmental conditions and plays a pivotal role in maintaining ecosystem stability. However, existing literature predominantly concentrates on the changes in plant homeostasis under different external environments. There is a paucity of comparative analyses focusing on the stoichiometric homeostasis attributes among different types of halophytes, particularly using these halophytes as a primary investigative lens. In this study, by analyzing the differences in organ and soil ecological stoichiometry as well as salt accumulation characteristics of three halophytes (Phragmites communis, Suaeda salsa, and Tamarix chinensis) in the Yellow River Delta, we revealed the salt ion enrichment capacity and stoichiometric homeostasis characteristics of the three halophytes and clarified the adaptive capacity of the three halophytes in saline soil environments. Our results indicated that S. salsa accumulated more Na+ and Mg2+, while P. communis maintained a low salt content in its surrounding soil. The soil C:N ratios of P. communis and S. salsa negatively correlated with most ions, while T. chinensis displayed a positive correlation with ions. S. salsa demonstrated the highest ion enrichment but the least homeostasis, whereas T. chinensis showed superior homeostasis. We hypothesize that T. chinensis might have experienced a faster growth rate during the study period, and P. communis' topsoil appears to be more conducive for plant growth. The different salt tolerance strategies of these plants influenced homeostasis, with S. salsa demonstrating greater adaptability to soil modifications and higher potential in saline land management. These insights enhance our understanding of the physiological and ecological adaptations of halophytes and their contribution to improving the quality of saline soils in the Yellow River Delta.
Applications of nanomaterials as treatments and diagnostic biosensors in microbial infections
Authors: Zou Yi , Tao Shihan , Li Jing , Wu Min , Zhou Xikun 
Published: October 2023

AbstractMicrobial infection is a major medical problem that seriously threatens public health. The abuse of antibiotics that help evolve the emergence of new drug‐resistance mechanisms has led to the wide‐spread and fast expansion of drug‐resistant bacteria, ultimately evolving into superbugs. This significantly impairs the timely and effective treatment of infections, thus threatening global human well‐being. Not all are pessimistic. Nanomaterials have emerged as an innovative choice. Due to their unique physical and chemical properties, superior bactericidal effects, and high biocompatibility, nanomaterials may help eradicate drug‐resistant bacteria to achieve complete remission of infectious diseases. As biological materials, nanomaterials can also improve the efficacy of existing drugs and treatments and even facilitate diagnostic efficiency. In this review, we aim to comprehensively summarize the antibacterial properties of different kinds of nanomaterials and their applications in other spheres related to treating infectious diseases (targeted therapy, phototherapy, vaccine development, and microbial diagnosis). We highlight the latest advances of nanomaterials in treating infectious diseases in different body systems. Finally, we conclude by discussing the weaknesses of currently available materials and unresolved scientific problems, which may provide insights into the development of approved agents that adequately overcome the notorious drug resistance and thereby provide unprecedented discoveries to improve treatments of the most severe bacterial infections.
Accelerometry‐assessed sleep clusters and cardiometabolic risk factors in adolescents
Authors: Wang Mingming , Flexeder Claudia , Harris Carla P. , Thiering Elisabeth , Koletzko Sibylle , Bauer Carl‐Peter , Schulte‐Körne Gerd , von Berg Andrea , Berdel Dietrich , Heinrich Joachim , Schulz Holger , Schikowski Tamara , Peters Annette , Standl Marie 
Published: October 2023

AbstractObjectiveThis study aimed to identify sleep clusters based on objective multidimensional sleep characteristics and test their associations with adolescent cardiometabolic health.MethodsThe authors included 1090 participants aged 14.3 to 16.4 years (mean = 15.2 years) who wore 7‐day accelerometers during the 15‐year follow‐up of the German Infant Study on the influence of Nutrition Intervention PLUS environmental and genetic influences on allergy development (GINIplus) and the Influence of Lifestyle factors on the development of the Immune System and Allergies in East and West Germany (LISA) birth cohorts. K‐means cluster analysis was performed across 12 sleep characteristics reflecting sleep quantity, quality, schedule, variability, and regularity. Cardiometabolic risk factors included fat mass index (FMI), blood pressure, triglycerides, high‐density lipoprotein cholesterol, high‐sensitivity C‐reactive protein, and insulin resistance (n = 505). Linear and logistic regression models were examined.ResultsFive sleep clusters were identified: good sleep (n = 337); delayed sleep phase (n = 244); sleep irregularity and variability (n = 108); fragmented sleep (n = 313); and prolonged sleep latency (n = 88). The “prolonged sleep latency” cluster was associated with increased sex‐scaled FMI (β = 0.39, 95% CI: 0.15–0.62) compared with the “good sleep” cluster. The “sleep irregularity and variability” cluster was associated with increased odds of high triglycerides only in male individuals (odds ratio: 9.50, 95% CI: 3.22–28.07), but this finding was not confirmed in linear models.ConclusionsThe prolonged sleep latency cluster was associated with higher FMI in adolescents, whereas the sleep irregularity and variability cluster was specifically linked to elevated triglycerides (≥1.7 mmol/L) in male individuals.
Global AI Initiatives: from Theory to Practice
Authors: Singh Vandana , Bilal Dania , Cox Andrew , Chidziwisano George Hope , Dinneen Jesse David 
Published: October 2023

ABSTRACTInformation Sciences is deeply invested in improving the future of AI globally. Information science researchers provide a critical voice in the growth of AI by bringing in perspectives related to AI Ethics, diversity, equity, inclusion, and AI education for all. AI is seeping into everyday life and is often a source of concern for people whose lives are impacted. The concerns of losing employment, inequitable access, and biases create a fear of AI among people. Library and information science educators and researchers have a rich history of working with local communities and representing local contexts. This experience places us in an important position to understand and evaluate AI applications and their varied impact in different contexts; for example, the same library‐related AI application would have different results in Europe versus Africa. However, AI and its applications in the global context are yet to be discussed and understood in the information science community.
How do emerging multinationals achieve sustainable development globally? The enabling mechanism of headquarter‐subsidiary structure in subsidiary sustainability
Authors: Zhou Chao , Xu Guannan , Sun Cong , Chang Xiaoran 
Published: October 2023

AbstractDespite of the increasing attention on Sustainable Development Goals (SDGs) implementation, emerging multinational corporations (EMNCs), and their foreign subsidiaries, as the promising contributors and main agents respectively to address SDG issues worldwide, have been rarely noticed in theoretical research. Drawing upon the loose coupling theory, this study seeks to address the unique challenges EMNCs facing in managing their foreign subsidiaries' SDG implementation, and informs on tackling the potential conflicts in meeting multiple SDG requirements of home and host countries. Based on a sample of 295 foreign subsidiaries from Chinese manufacturing firms, this study adopts polynomial quadratic regression with response surface analysis to examine the relationship between headquarter‐subsidiary (HQS) coupling structure and subsidiary sustainable development, as well as the role of parent corporate environmental responsibility (CER) and FDI motives in this process. Our findings demonstrate support for the positive effect of HQS coupling structure on subsidiary sustainable development, and the moderating role of FDI motives is confirmed. This study reveals the key mechanisms and contingencies of SDG implementation at the subsidiary level, and provides theoretical insights for EMNCs to tackle SDG issues globally, obtain legitimacy locally and deepen international expansion accordingly.
What Makes On‐Chip Microdevices Stand Out in Electrocatalysis?
Authors: Luo Wen , Yan Xin , Pan Xuelei , Jiao Jinying , Mai Liqiang 
Published: October 2023

AbstractClean and sustainable energy conversion and storage through electrochemistry shows great promise as an alternative to traditional fuel or fossil‐consumption energy systems. With regards to practical and high‐efficient electrochemistry application, the rational design of active sites and the accurate description of mechanism remain a challenge. Toward this end, in this Perspective, a unique on‐chip micro/nano device coupling nanofabrication and low‐dimensional electrochemical materials is presented, in which material structure analysis, field‐effect regulation, in situ monitoring, and simulation modeling are highlighted. The critical mechanisms that influence electrochemical response are discussed, and how on‐chip micro/nano device distinguishes itself is emphasized. The key challenges and opportunities of on‐chip electrochemical platforms are also provided through the Perspective.