bluuebunny/crossref_metadata_2025_split huggingface dataset:
The triple-drug combination DBDx enhances the antitumor efficacy of PD-1 antibody associated with Treg modulation
Authors: Shan Chuankun , Wang Yuexuan , Li Yi , Yang Siqi , Sheng Weijin , Liu Xiujun 
Published: December 2023

Objective:This study investigated the antitumor efficacy of programmed cell death protein-1 (PD-1) antibody and DBDx, a triple-drug combination of dipyridamole, bestatin, and dexamethasone, and their related immunomodulation.Materials and Methods:Mouse melanoma B16, mouse Lewis lung carcinoma, and mouse breast carcinoma 4T1 were used for evaluating thein vivotherapeutic efficacy of DBDx, PD-1 antibody, and their combination. The peripheral blood and tumor tissues of 4T1 tumor-bearing mice were collected to analyze regulatory T cells and measured using flow cytometry.Results:The combination of PD-1 antibody and DBDx enhanced the therapeutic efficacy against B16 melanoma. The suppression of tumor growth by PD-1 antibody and DBDx was more significant than that by anti-PD-1 monotherapy. The tumor growth inhibition rates of PD-1 antibody, DBDx, and their combination were 54.0%, 72.4%, and 83.1%, respectively, suggesting a synergistic effect as determined by the coefficient of drug interaction. No significant changes were found in the body weights in all the above groups, indicating that the treated mice tolerated the applied drug doses. Similarly, enhanced therapeutic efficacy of the PD-1 antibody and DBDx combination was observed in murine Lewis lung carcinoma and 4T1 breast cancer models. In 4T1 breast cancer-bearing mice, the immunotherapy-related changes in lymphocytes in peripheral blood and tumor microenvironment were evaluated with flow cytometry. Compared with anti-PD-1 monotherapy, peripheral blood and tumor-infiltrating lymphocytes were found a lower ratio of regulatory T cell (Treg) subset cells and a higher ratio of CD8+/Treg cells.Conclusions:The combination of PD-1 antibody and DBDx could achieve enhanced therapeutic antitumor efficacy than anti-PD-1 monotherapy, suggesting potential for using the triple-drug combination DBDx in cancer immunotherapy.
Dosimetry of intensity-modulated radiation therapy and volumetric-modulated arc therapy techniques after modified radical mastectomy for breast cancer and hypofractionated intensity-modulated radiotherapy
Authors: Lin Hongxiao , Sheng Xuren , Liu Haowu , Zhang Peng , Liu Yunqin , Zang Chunbao 
Published: December 2023

Objective:
The aim of this study was to compare the advantages and disadvantages of intensity-modulated radiation therapy (IMRT) and volumetric-modulated arc therapy (VMAT) in patients with left-sided breast cancer who underwent hypofractionated IMRT after a modified radical mastectomy.

Materials and Methods:
Twenty patients who required adjuvant radiotherapy after modified radical mastectomy were randomly selected, and a specified dose of 43.5 Gy/15 F was used to plan for IMRT or VMAT. Dose–volume histograms (DVHs) were utilized to evaluate the dose distribution of the planning target volumes (PTVs) and organs at risk (OARs).

Results:
VMAT demonstrated a greater and more uniform dose distribution of PTVs and lower number of monitor units. No significant differences were found in V5 of the affected lung and heart between the two techniques (P > 0.05). The V10, V20, V30, and Dmean of the affected lung and V10, V20, V30, V40, Dmean, and Dmax of the whole heart were better in the VMAT than in the IMRT (P < 0.05). The Dmean and Dmax of the left anterior descending (LAD) branch of the coronary artery of the heart were better in the VMAT (P < 0.05), and the use of the VMAT effectively reduced the cardiopulmonary dose. A significant advantage of V30 and Dmean was also found in VMAT (P < 0.05).

Conclusion:
These findings indicate that VMAT has higher clinical significance than IMRT, because it improved the dose distribution in the target area, reduced the cardiopulmonary dose, protected the OARs (e.g. thyroid), and shortened the treatment duration.
Predictors of death in hospitalized elderly patients with COVID-19 in Mashhad, Iran, in 2021: A historical cohort study
Authors: Biniaz Vajihe , Safavi Alireza Afshari , Zamani Forogh , Rahnama Mozhgan , Abdollahimohammad Abdolghani , Ildarabadi Eshagh 
Published: December 2023

Objective:
The present study aimed to identify predictive factors for mortality among elderly individuals infected with COVID-19.

Methods and Materials:
This historical cohort study was conducted from July to December 2021 in the specialized departments for COVID-19 patients at one of the hospitals in Mashhad, Iran. Data were collected from the medical records of 404 elderly patients. Sampling was conducted using the convenience sampling method. Data were gathered through a demographic and clinical checklist developed by the researcher. Univariate and multivariate Cox regression were used to analyze the data.

Results:
The mortality rate among elderly individuals was 25% (n = 101). Multiple regression analysis revealed significant associations between mortality and age (hazard ratio [HR] = 0.58, 95% confidence interval [CI]: 0.38, 0.88; P = 0.011), level of consciousness (HR = 0.31, 95% CI: 0.19, 0.50; P < 0.001), and SpO2 (HR = 0.58, 95% CI: 0.37, 0.92; P = 0.022). The probability of survival after the 19th day of hospitalization was 50%.

Conclusions:
Determining predictors of death allows for early identification of elderly individuals at risk and enables the health-care team to provide more effective care, ultimately saving the lives of elderly individuals by allocating appropriate facilities and equipment.
Occupation-related airborne diseases: Management and prevention of tuberculosis among nurses working in Ekiti State University Teaching Hospital
Authors: Olorunfemi Olaolorunpo , Samuel Damilola , Adebiyi Joseph Adekunle , Akindipe Adewole Peter , Tijani Wakeel Adelani 
Published: December 2023

ABSTRACT

Objective:
More health workers die from infectious diseases such as tuberculosis (TB) than from any other infectious agent, so the current study is designed to assess TB treatment and preventive measures as they relate to nursing care practice.

Materials and Methods:
A cross-sectional study was conducted among 82 nurses from December 2022 to January 2023. The data were collected through a self-developed questionnaire and analyzed by frequency table and analysis of variance (ANOVA) statistics.

Results:
The researchers found that nurses have sufficient knowledge on Infection Prevention and Control (IPC) policy, but not all nurses follow this management protocol, and the reason for their action is addressed in this study. The management and preventive measures used by the participants were identified as: proper cough etiquette/hygiene, working in a well-ventilated area, use of mask, appropriate disposal of used items and so on was reported. Moreover, this study also discovered that there is a positive correlation between nurses who had received training in IPC policy and their use of airborne preventive measures for TB patients (F = 1.87, P = 0.002) as well as a positive correlation between the availability of resources and their adherence to the proper use of airborne preventive measures when caring for TB patients (F = 1.96, P < 0.001).

Conclusion:
We proposed infection and control training for nurses and adequate equipment supplies to the TB ward which are required in quick TB diagnosis, and must be carried out on a regular basis by health-care personnel, for efficient nursing practice. Ensuring proper safety equipment and isolation units should be available and assessable for nurses or other health workers showing sign or symptoms of TB. Similarly, it is necessary for government to put in place the control and regulations that will safeguard nurses and mandate them to adopt TB prevention protocols, which will aid in lowering the prevalence of TB among nurses.
The contribution of Academician A.V. Ryndina to the study of ancient Russian and modern church art
Authors: Островская Т.А. 
Published: December 2023

В статье автор анализирует научные труды доктора искусствоведения, профессора, заслуженного деятеля искусств Российской Федерации, художника Анны Вадимовны Рындиной, посвященные сложению иконографии, технике изготовления, анализу стиля, атрибуции предметов древнерусской мелкой пластики XIV–XV веков и деревянной церковной скульптуре XIV–XVIII веков. Целью работы является обобщение, анализ и оценка вклада академика А.В. Рындиной в развитие научного понимания древнерусского и церковного искусства Нового времени. Для достижения этой цели проведен обзор и анализ научных публикаций, монографий и статей, написанных искусствоведом, а также реализованных ею научно-просветительских проектов.
The article presents an analysis of the scientific heritage of Anna Vadimovna Ryndina, Doctor of Art History, Professor, Honoured Art Worker of the Russian Federation, artist. The aim of the work is to analyse and evaluate the contribution of Academician A.V. Ryndina to the development of scientific understanding of Old Russian and church art of the new time. To achieve this goal, the author reviews and analyses scientific publications, monographs and articles written by the art historian, as well as scientific and educational projects implemented by her, devoted to the development of iconography, production techniques, style analysis, and attribution of objects of Old Russian fine plastic art of the 14th – 15th centuries and wooden church sculpture of the 14th – 18th centuries.
Pengaruh human capital dan financial capital terhadap manajemen bencana tanah longsor di kabupaten Banjarnegara dengan pendekatan sustainabilty livelihood
Authors: Subiyanto Munifah Jauza , Dewanti Diah Setyawati , Mubarrok Wafiyulloh 
Published: December 2023

Penelitian ini bertujuan untuk menganalisis Pengaruh Human Capital dan Financial Capital terhadap Manajemen Bencana Tanah Longsor di Kabupaten Banjarnegara. Subyek dalam penelitian ini adalah penduduk yang tinggal di Desa Sampang dan Desa Binangun Kecamatan Karangkobar, Kabupaten Banjarnegara. Dalam penelitian ini sampel yang diambil yaitu sebanyak 100 responden yang dipilih dengan menggunakan metode purposive sampling. Alat yang digunakan dalam pengolahan data dan analisis yaitu SPSS 16.0 for windows dan Path Analysis (analisis jalur). Adapun hasil yang didapat adalah; (1) Variabel pendapatan dan variabel perspektif pentingnya pendidikan mempengaruhi manajemen bencana secara langsung dengan koefisien unstandarized sebesar 0,394 dan 0,991, (2) Variabel kesehatan mempengaruhi manajemen bencana secara tidak langsung terhadap masyarakat dengan koefisien unstandarized sebesar 0,455.

This study aims to analyze the Effect of Human Capital and Financial Capital on Landslide Disaster Management in Banjarnegara Regency. The subjects in this study were residents living in Sampang and Binangun Villages, Karangkobar District, Banjarnegara Regency. In this study the samples taken were as many as 100 respondents who were selected using the purposive sampling method. The tools used in data processing and analysis are SPSS 16.0 for windows and Path Analysis. The results obtained are; (1) Income variables and perspective variables of the importance of education affect disaster management directly with unstandarized coefficients of 0.394 and 0.991, (2) Health variables affect disaster management indirectly with society with unstandarized coefficients of 0.455.
Increased Subjectivity in Audio Description of Visual Art
Authors: Silvia Soler Gallego  , Luque Colmenero María Olalla 
Published: December 2023

This article discusses a focus group reception study of visual art audio description (AD) that focuses on the standard style as described in previous corpus-based studies, along with one of the less frequent approaches also found among current practices, namely the “gist” style. The results from the qualitative analysis of the focus group discussions show that user experience of the gist AD style varies among participants, with some reporting positive impressions thereof. In addition, users’ experience of AD has several layers, since the discussions progressed from specific aspects to broader questions dealing with the very definition of AD and user preferences regarding visual arts.
Lay Summary
This article talks about a research study that looked at how people perceive audio descriptions (AD) in visual art. Audio description is a way of providing information about visual elements for individuals who are blind or visually impaired. The study focused on two styles: the standard style, which is commonly used and has been studied before, and a less common approach known as the "gist" style. The gist style is type of AD where only a few visual components are mentioned without many conceptual connections between them and with high importance to the voice and it modulations. The researchers conducted focus group discussions to understand how participants experienced these different AD styles. These discussions are group conversations where participants share their opinions and experiences about a particular topic, guided by a moderator. The results were obtained through qualitative analysis, where the focus is on understanding people's experiences and opinions in-depth, often involving open-ended discussions rather than quantitative data. They revealed that people had varying opinions about the gist style. Some participants liked it, while others didn't. Moreover, the discussions went beyond just talking about specific aspects of AD; they delved into broader questions about what AD is and what users prefer when it comes to describing visual art. The study found that opinions on the gist style varied among participants, and the discussions went beyond specific details of AD to explore broader questions about its definition and user preferences in the context of visual arts.
PROBLEMS OF DETERMINING THE CONTENT OF THE LEGALITY OF BEHAVIOR
Authors: Бортников Д.М. 
Published: December 2023

Статья посвящена исследованию содержания понятия «правомерное поведение». Несмотря на то, что термин активно используется в научных источниках и имеет прикладное значение, критерии определения поведения как правомерного до настоящего времени не определены нормативно, что свидетельствует о недостаточности проработки. Проблема определения содержания и критериев, на основании которых оно может быть установлено, обусловлено тем, что, правомерность может рассматриваться в узком и в широком смысле. При этом существует определенная грань, за которой поведение определяется уже как неправомерное. Неправомерность, по своей сути – это либо не соответствие нормам права либо прямое нарушение установленных на нормативном уровне запретов. В отношении правомерности подобных границ нет. Сопутствующей этому проблемой является проблема отграничения злоупотребления правом от правомерного поведения. Отграничение необходимо, потому что злоупотребление правом не только порицается со стороны социума, но и предполагает возможность негативной оценки со стороны государства, следствием которой является отказ в защите права. Автором исследования предложена формулировка содержания правомерного поведения как юридического термина.
The article is devoted to the study of the content of the concept of «lawful behavior». Despite the fact that the term is actively used in scientific sources and has applied meaning, the criteria for defining behavior as lawful have not been defined normatively so far, which indicates the lack of elaboration. The problem of determining the content and criteria on the basis of which it can be established is due to the fact that, lawfulness can be considered in a narrow and in a broad sense. At the same time, there is a certain boundary beyond which the behavior is already defined as unlawful. Illegality, in its essence, is either non-compliance with the rules of law or a direct violation of the established at the normative level prohibitions. With respect to lawfulness there are no such boundaries. A related problem is the problem of differentiating the abuse of law from lawful behavior. The distinction is necessary because the abuse of right is not only condemned by society, but also involves the possibility of negative assessment by the state, the consequence of which is the denial of the right protection. According to the results of the study the formulation of the content of lawful behavior as a legal term is proposed.
CORPORATE RESPONSIBILITY OF BUSINESS – FINDING A BALANCE BETWEEN SOCIETY AND THE STATE
Authors: Нардина О.В. , Струтинская Т.А. , Казановская Ю.А. 
Published: December 2023

Понятие и сущность корпоративной ответственности, подходы к ее реализации являются наиболее актуальными темами современных дискуссий, возникающих между обществом и государством, с одной стороны, и субъектами предпринимательской деятельности - с другой. Авторы считают, что реализация корпорациями социальных проектов должна носить инвестиционный характер и в перспективе приносить им прибыль, а обществу и государству социальную стабильность.
The concept and essence of corporate responsibility, approaches to its implementation are the most relevant topics of modern discussions arising between society and the state, on the one hand, and business entities, on the other. The authors believe that the implementation of social projects by corporations should be of an investment nature and in the future bring them profit, and social stability to society and the state.
Pelatihan Pengajaran Bahasa Inggris Usia Dini Bagi Guru-Guru Di PAUD & TK Dewi Sartika Tanjung Pura
Authors: Nurul Hasanah, Nur Afrida Syarifah Hidayani, 
Published: December 2023

Bahasa adalah bagian dari keseluruhan tingkah laku manusia. Oleh karena itu bahasa merupakan gejala atau ujaran yang dapat diamati. Tujuan dari pengabdian ini Untuk membekali anak agar memiliki kemampuan komunikasi yang baik di era globalisasi, maka pengajaran bahasa Inggris kepada anak sejak usia dini akan sangat menguntungkan. Metode pada pengabdian ini menggunakan penelitian kualitatif. Penelitian kualitatif bertujuan memperoleh gambaran seutuhnya mengenai suatu hal menurut pandangan manusia yang diteliti. Penelitian kualitatif berhubungan dengan ide, persepsi, pendapat, atau kepercayaan orang yang diteliti; kesemuanya tidak dapat diukur dengan angka. Hasil pengabdian dilaksanakan dengan tatap muka dengan metode diskusi dan praktik pengajaran berjalan dengan baik dan lancar. Peserta kegiatan adalah guru PAUD&TK Dewi Sartika yang berjumlah 12 orang. Semua peserta tidak ada yang lulusan Bahasa Inggris. Rata-rata adalah lulusan Pendidikan PAUD dan lulusan Pendidikan agama Islam. Beberapa alasan yang disampaikan para guru terkait pembelajaran Bahasa Inggris bagi anak PAUD&TK. Diantaranya adalah kurangnya kepercayaan diri oleh para guru untuk mengucapkan vocabularies dalam Bahasa Inggris. Guru masih enggan dan ragu untuk mempraktekkan Bahasa inggris dalam percakapan sehari-hari dikelas. Mereka juga menyampaikan kurangnya pengetahuan dan konsep pengajaran dalam Bahasa Inggris.
Pemanfaatan Penggunaan Chat GPT Dalam Meningkatkan Kemampuan Pengajaran Bahasa Inggris
Authors: Chairunnisa Nazli Fahada, Jonris Tampubolon, 
Published: December 2023

ChatGPT is an AI tool that has sparked debates about its potential implications for education. We used the SWOT analysis framework to outline ChatGPT’s strengths and weaknesses and to discuss its opportunities for and threats to education. ChatGPT can increase access to information, facilitate Personalised and complex learning, and decrease teaching workload, thereby making key processes and tasks more efficient. The weaknesses are a lack of deep understanding, difficulty in evaluating the quality of responses, a risk of bias and discrimination, and a lack of higher-order thinking skills. The aim of this community service is to inform about the benefits of using ChatGPT in teaching English for teachers at Mts Muhammadiyah 15 Medan and to conduct a SWOT analysis of ChatGPT.
Educação inclusiva: Uma Avaliação de Implementação
Authors: Laranjeira de Sá Ana Karine 
Published: December 2023

Esse artigo apresenta a importância da política de educação inclusiva, efeitos do federalismo e descentralização, destacao ciclo de políticas públicas, com ênfase aos elos deimplementação e avaliação. Objetivo principal é avaliar a qualidade de implementação da política de educação inclusiva no Instituto Federal de Pernambuco-Pesqueira. Metodologicamente, o desenho de pesquisa é de caráter descritivo de cunho quanti-qualitativa, emprega a estatística descritiva como método de análise das afirmativas têm-se a análise de componentes principais , cujo instrumento é um survey com perguntas abertas e fechadas, aplicados sob entrevista a 266 pessoas , com 97% de participação; Todas as análises estatísticas foram realizadas a partir do Statistical Package for Social Sciences. Resultados: o IFPE-Pesqueira, atinge 69,27% dos indicadores estabelecidos na caracterização geral de inclusão; 52,94% dos dispositivos legais; 71,1% dos docentes dizem ser pouco experientes e 19,3% não possuem experiência com alunos com deficiência e na ACP não se percebem competentes pedagogicamente para atuar com discentes dentro de suas diversidades e com deficiência, com média de 0,544. Conclui-se que a avaliação de implementação da política de educação inclusiva nessa Instituição, é um instrumento capaz de visualizar as falhas, ganhos e benefícios, sendo possível dessa forma, traçar um plano para melhorar a qualidade deste tipo específico de educação, cujo ponto marcante é a necessidade de investimento na atualização do docente quanto ao tema, possibilitando favorecer a competência pedagógica.
Por Uma Vida Livre De Violência: Contribuições À Avaliação Das Medidas Protetivas De Urgência Da Lei Maria Da Penha Em Pernambuco
Authors: Florêncio Jackeline Freire 
Published: December 2023

A violência doméstica e familiar contra as mulheres, nos moldes previstos na Lei nº 11.340/2006 (Lei Maria da Penha), é o problema de políticas públicas abordado neste artigo. Trata-se de pesquisa no âmbito da avaliação de políticas públicas, com o objetivo de captar a percepção de gestoras/es e técnicas/os do Sistema de Segurança Pública, do Sistema de Justiça, bem como do Poder Executivo sobre as Medidas Protetivas de Urgência da Lei Maria da Penha; observar a percepção do impacto do deferimento ou indeferimento das medidas na situação de violência relatada por mulheres que as solicitaram e identificar as fragilidades, potencialidades e boas práticas desenvolvidas no cumprimento e implementação das medidas. Essa aferição se deu a partir de entrevistas semiestruturadas com 9 (nove) agentes públicos (operadoras/es do sistema de justiça, policiais e gestoras/es públicas/os) e com 14 (catorze) mulheres em situação de violência que demandaram o serviço: 10 (dez) com medidas deferidas e 4 (quatro), indeferidas. Metodologicamente, é uma avaliação somativa, externa, e, no que diz respeito ao tipo de problema ao qual responde, trata-se de uma avaliação de implementação (ou de processo), com vistas a contribuir com uma avaliação mais ampla da política.Quanto aos resultados apresentados, observou-se uma ampla legitimação do mecanismo das medidas protetivas de urgência, assim como apontaram-se as fragilidades na intersetorialidade e articulação da rede de atendimento, a demora no deferimento e a dificuldade de fiscalização das medidas, o que compromete seu caráter emergencial.