bluuebunny/crossref_metadata_2025_split huggingface dataset:
Gasification of solid biomass or fast pyrolysis bio‐oil: Comparative energy and exergy analyses using AspenPlus®
Authors: Buelvas Ana , Quintero‐Coronel Daniel A. , Vanegas Oscar , Ortegon Katherine , Bula Antonio , Mesa Jaime , González‐Quiroga Arturo 
Published: January 2024

AbstractThe conversion of biomass residues into syngas through gasification is attractive for energy and process industry applications. However, transportation, storage, and operational challenges limit the conventional direct solid biomass gasification process. To address these issues, the intermediate conversion of biomass to bio‐oil has emerged as a promising alternative. Bio‐oil offers improved transport and storage capabilities due to its higher mass and energy density, enabling the decoupling of solid biomass supply and syngas demand. This study compares two routes for syngas production: direct gasification of solid biomass and indirect gasification using bio‐oil from biomass pyrolysis as an intermediate with biochar and pyrolysis gas supplying thermal energy to the pyrolysis stage. Biochar combustion provides about 1.4 MJ kg−1 of dry biomass to maintain the pyrolysis temperature at 480°C. Using AspenPlus® simulations, the composition and Low Heating Value of the syngas produced by both routes are analyzed. Energy and exergy analysis at different equivalence ratios and temperatures revealed that direct gasification has higher efficiencies than indirect gasification. At 1000°C and an equivalence ratio of 0.4, the highest energy and exergy efficiencies occurred in direct gasification processes. The energy efficiency of direct and indirect gasification amounted to 62% and 53%, respectively. At the same time, the corresponding exergy efficiencies were 65% and 61%. The syngas of direct and indirect gasification processes is a starting point to produce energy, synthetic fuels, and chemicals; this study provides insights for designing and optimizing biomass gasification processes.
Puget Sound sediment cleanup remedy effectiveness retrospective
Authors: Patmont Clay , Healy Rob 
Published: January 2024

Abstract
The monitoring of completed large-scale sediment remediation projects has revealed mixed effectiveness at reducing risks, thus highlighting uncertainties regarding whether and which remedial measures are necessary to achieve protective goals. To support valid statements about changes over time and the overall effectiveness of sediment remedial action, robust pre- and postremediation monitoring is required with sufficient time points, reference sites, and biological metrics. The five completed Puget Sound sediment remediation case studies reviewed here (Bellingham Bay, St. Paul Waterway, Eagle Harbor, Hylebos Waterway, and Sinclair Inlet) employed particularly robust remedy effectiveness monitoring programs that spanned decades, revealing common lessons for improving remediation outcomes. First, although sediment remediation can play an important role in reducing contaminant exposure in areas with higher sediment concentrations, at lower levels, sediment links with fish tissue concentrations diminish. As water column exposure from diverse sources becomes predominant, remediating sediments with lower concentrations yields proportionately less risk reduction. Second, timely monitoring of effective source controls achieving substantial (i.e., &gt;80%) contaminant source load reductions as well as large-scale capping projects have revealed rapid changes in Puget Sound surface sediment concentrations and biological recovery metrics with an average recovery half-time of 1.6 ± 0.8 years. The weight of evidence suggests that natural recovery of Puget Sound surface sediments is significantly accelerated by exchange across the sediment–water interface from benthic organism feeding behaviors, porewater flux, and tide-generated currents. As a result, effective source controls in Puget Sound have rapidly improved surface sediment quality and achieved more significant risk reductions than broadscale sediment remediation. Going forward, comprehensive Puget Sound source control efforts that incorporate robust monitoring in an adaptive management framework are the best way to achieve protective remediation objectives. These lessons may apply more broadly across similar complex urban aquatic ecosystems. Integr Environ Assess Manag 2024;20:1355–1365. © 2024 The Authors. Integrated Environmental Assessment and Management published by Wiley Periodicals LLC on behalf of Society of Environmental Toxicology & Chemistry (SETAC).
Key Points
Reviews of completed sediment remediation actions in Puget Sound reveal that remediating sediments with lower concentrations yields proportionately less risk reduction, and that effective source controls have achieved more significant risk reduction than broadscale sediment remediation.
Green construction practices and economic performance: The mediating role of social performance and environmental performance
Authors: Ahmed Mukhtar , Khan Noman , Ayub Muhammad 
Published: January 2024

Abstract
Currently, there is a surge in the adoption of green construction practices (GCP) to address and attempt to alleviate the adverse effects of construction activities on the natural environment. The current research surrounding sustainability in the industry has witnessed a notable surge in efforts, primarily driven by a growing consciousness of environmental concerns. In this context, it is worth noting that the focus of assessment schemes in developed countries has predominantly gravitated toward economic and environmental factors, with relatively less emphasis placed on social performance (SP). Many researchers have underscored this disparity, highlighting the need for a more comprehensive approach encompassing all three sustainability dimensions. Hence, the present research examines the effects of green construction practices on economic performance (ECP) while considering the mediating role of environmental performance (EP) and SP. The results showed no direct impact of GCP on ECP. However, the mediating role of SP and EP in the association between GCP and ECP was found to be statistically significant. The present study provides several implications. This study presents empirical evidence that implementing GCP yields several benefits for contractors, including cost reduction in waste management, legal expenses, and energy consumption. These cost savings effectively offset the initial investment required to implement GCP, enabling construction projects to attain ECP thresholds. This study provides a significant contribution to the expanding corpus of knowledge concerning green building site practices and construction management. It offers novel insights into the influence of a project's EP and SP on its economic feasibility. Furthermore, this research study has effectively showcased the positive impact of GCP on construction projects' environmental construction performance, particularly concerning environmental and social considerations. Integr Environ Assess Manag 2024;20:1396–1406. © 2024 SETAC
Key Points
We examined the effects of green construction practices on economic performance (ECP) while considering the mediating role of environmental performance (EP) and social performance (SP). The results showed no direct impact of green construction practices on ECP; however, a statistically significant mediating role of SP and EP was found in the relationship between green construction practices and ECP. We found that green construction practices improve the ECP of construction projects in the presence of environmental and social aspects, thus helping the contractor reduce costs associated with waste management, legal expenses, energy management, and material management.
Biochemical responses and antioxidant defense mechanisms in Channa Striatus exposed to Bisphenol S
Authors: Mohan Sini , Jacob Jubi , Malini Nair Achuthan , Prabhakar Reshma , Kayalakkakathu Roy George 
Published: January 2024

AbstractBisphenol S (BPS), a BPA analog and a safer alternative, is utilized in a diverse range of industrial applications, such as making polycarbonate plastics, epoxy resins, thermal receipt papers, and currency bills. Recently, the increased use of BPS in containers and packages for daily life has been interrogated due to its identical chemical structure and probable endocrine‐disrupting actions as BPA has. The present study aimed to evaluate the alterations in biochemical indices and antioxidant enzymes as certain indicators of the endocrine‐disrupting effect of BPS in Channa striatus, a freshwater fish. BPS‐exposed fish species were subjected to three sub‐lethal concentrations of BPS (1, 4, and 12 ppm) and observed after an interval of 7 and 21 days. Exposure to BPS caused a reduction in the level of protein in muscle, gonads and the liver due to an impairment of protein synthesis. Levels of cholesterol in the muscle, gonads, and liver of BPS‐exposed fish were found to be decreased after treatment, indicating either an inhibition of cholesterol biosynthesis in the liver or reduced absorption of dietary cholesterol. The levels of antioxidant enzymes such as superoxide dismutase, catalase, glutathione reductase and glutathione peroxidase showed remarkable increases, while the activity of glutathione S‐transferase decreased considerably, indicating the antioxidant defense mechanism to counteract the oxidative stress induced by BPS. Moreover, a significant increase was noted in the level of lipid peroxidation products, like malondialdehyde and conjugate diene, which represent biomarkers of oxidative stress. The histoarchitecture changes were also observed in the liver, muscle and gonads of BPS‐treated fish species. The present study showed that sub‐lethal exposure to BPS significantly influenced the activities of these enzymes and peroxidation byproducts. From this study, it is concluded that BPS‐caused toxic effects in fish species lead to an imbalance in the antioxidant defense system. It is clearly indicated that BPS toxicity could lead to susceptible oxidative stress in various tissues and could damage vital organs.
Diagnostic accuracy of a novel point‐of‐care test for simultaneous detection of anti‐transglutaminase IgA and anti‐deamidated gliadin IgG antibodies
Authors: Parrinello Giuseppe , Da Re Mirella , Grizzo Francesca , Camelliti Simone , Cozzi Marzia , Marinoni Francesca , Villalta Danilo 
Published: January 2024

AbstractBackgroundPoint‐of‐care tests (POCTs) may have a role in detecting undiagnosed cases of Celiac disease (CD). We assessed the diagnostic accuracy of a novel POCT, compared with the conventional serological methods, for simultaneous anti‐transglutaminase (tTG) IgA and anti‐deamidated gliadin (DGP) IgG antibody detection. Furthermore, we evaluated the effect of different biological matrices (whole blood and serum) on test performance.MethodsSerum and whole blood from celiac or suspected celiac patients who underwent duodenal biopsy were assayed for the presence of anti‐tTG IgA and anti‐DGP IgG both with the reference standard methods (Thermo Fisher Scientific, Uppsala, Sweden) and with the POCT (PRIMA Lab SA, Balerna, Switzerland).Results266 sera (101 negative and 165 positive) and 60 whole blood samples (34 positive and 26 negative) were included in the study. POCT for anti‐DGP IgG showed a sensitivity of 84.3% and a specificity of 90.1%, with positive (PPV) and negative predictive values (NPV) of 91.07% and 82.73%. POCT for anti‐tTG IgA showed a sensitivity of 98.31% and a specificity of 98.02%, with a PPV and NPV of 98.31% and 98.02%. Test accuracies were 86.94% and 98.17%, respectively. The agreement of the results between the two different matrices showed a strong correlation rate: 95% for anti‐DGP IgG and 100% for anti‐tTG IgA.ConclusionThe anti‐tTG IgA/anti‐DGP IgG‐based POCT showed good diagnostic accuracy with comparable sensitivities and specificities to reference standard methods in detecting CD in symptomatic patients and could be considered as a mass screening test before referring to conventional serology.
Lifetime adversity predicts depression, anxiety, and cognitive impairment in a nationally representative sample of older adults in the United States
Authors: Ahn SangNam , Kim Seonghoon , Zhang Hongmei , Dobalian Aram , Slavich George M. 
Published: January 2024

AbstractObjectiveAlthough life stress and adversity are well‐known risk factors for mental health problems and cognitive impairment among older adults, limited research has comprehensively examined the impact of both childhood and adulthood adversity on psychiatric and cognitive impairment symptoms over a prolonged period. To address this issue, we investigated how lifetime adversity exposure is related to symptoms of depression, anxiety, and cognitive impairment in a nationally representative, longitudinal sample of older adults in the United States.MethodWe analyzed data from the Health and Retirement Study (1992–2016). The sample included 3496 individuals (59.9% female), aged ≥64 years old (Mage = 76.0 ± 7.6 years in 2016). We used the individual‐level panel data and ordinary least squares regressions to estimate associations between childhood and adulthood adversities, and later‐life depression, anxiety, and cognitive impairment.ResultsMany participants experienced a significant early life (38%) or adulthood (79%) stressor. Moreover, experiencing one childhood adversity (vs. none) was associated with a 17.4% increased risk of adulthood adversity. Finally, as hypothesized, childhood adversity exposure was related to experiencing more depression and anxiety symptoms in later life, whereas adulthood stressor exposure predicted more cognitive impairment as well as more depression and anxiety symptoms.DiscussionThese findings demonstrate significant associations between lifetime adversity and symptoms of depression, anxiety, and cognitive impairment in older adults. Screening for lifetime stressors may thus help healthcare professionals and policymakers identify individuals who could potentially benefit from interventions designed to reduce stress and enhance resilience.
Myocardial proteome changes in aortic stenosis rats subjected to long‐term aerobic exercise
Authors: Mota Gustavo Augusto Ferreira , de Souza Sérgio Luiz Borges , Vileigas Danielle Fernandes , da Silva Vitor Loureiro , Sant'Ana Paula Grippa , Costa Licia Carla da Silva , Padovani Carlos Roberto , Zanatti Bazan Silméia Garcia , Buzalaf Marília Afonso Rabelo , Santos Lucilene Delazari dos , Okoshi Marina Politi , Gatto Mariana , Cicogna Antonio Carlos 
Published: January 2024

AbstractThe effects of exercise training (ET) on the heart of aortic stenosis (AS) rats are controversial and the mechanisms involved in alterations induced by ET have been poorly clarified. In this study, we analyzed the myocardial proteome to identify proteins modulated by moderate‐intensity aerobic ET in rats with chronic supravalvular AS. Wistar rats were divided into four groups: sedentary control (C‐Sed), exercised control (C‐Ex), sedentary aortic stenosis (AS‐Sed), and exercised AS (AS‐Ex). ET consisted of five treadmill running sessions per week for 16 weeks. Statistical analysis was performed by ANOVA or Kruskal–Wallis and Goodman tests. Results were discussed at a significance level of 5%. At the end of the experiment, AS‐Ex rats had higher functional capacity, lower blood lactate concentration, and better cardiac structural and left ventricular (LV) functional parameters than the AS‐Sed. Myocardial proteome analysis showed that AS‐Sed had higher relative protein abundance related to the glycolytic pathway, oxidative stress, and inflammation, and lower relative protein abundance related to beta‐oxidation than C‐Sed. AS‐Ex had higher abundance of one protein related to mitochondrial biogenesis and lower relative protein abundance associated with oxidative stress and inflammation than AS‐Sed. Proteomic data were validated for proteins related to lipid and glycolytic metabolism. Chronic pressure overload changes the abundance of myocardial proteins that are mainly involved in lipid and glycolytic energy metabolism in rats. Moderate‐intensity aerobic training attenuates changes in proteins related to oxidative stress and inflammation and increases the COX4I1 protein, related to mitochondrial biogenesis. Protein changes are combined with improved functional capacity, cardiac remodeling, and LV function in AS rats.
Regulation of spermatogonial stem cell differentiation by Sertoli cells‐derived exosomes through paracrine and autocrine signaling
Authors: Tian Hairui , Wang Xingju , Li Xiaoxiao , Song Weixiang , Mi Jiaqi , Zou Kang 
Published: January 2024

AbstractIn the orchestrated environment of the testicular niche, the equilibrium between self‐renewal and differentiation of spermatogonial stem cells (SSCs) is meticulously maintained, ensuring a stable stem cell reserve and robust spermatogenesis. Within this milieu, extracellular vesicles, specifically exosomes, have emerged as critical conveyors of intercellular communication. Despite their recognized significance, the implications of testicular exosomes in modulating SSC fate remain incompletely characterized. Given the fundamental support and regulatory influence of Sertoli cells (SCs) on SSCs, we were compelled to explore the role of SC‐derived exosomes (SC‐EXOs) in the SSC‐testicular niche. Our investigation hinged on the hypothesis that SC‐EXOs, secreted by SCs from the testes of 5‐day‐old mice—a developmental juncture marking the onset of SSC differentiation—participate in the regulation of this process. We discovered that exposure to SC‐EXOs resulted in an upsurge of PLZF, MVH, and STRA8 expression in SSC cultures, concomitant with a diminution of ID4 and GFRA1 levels. Intriguingly, obstructing exosomal communication in a SC‐SSC coculture system with the exosome inhibitor GW4869 attenuated SSC differentiation, suggesting that SC‐EXOs may modulate this process via paracrine signaling. Further scrutiny revealed the presence of miR‐493‐5p within SC‐EXOs, which suppresses Gdnf mRNA in SCs to indirectly restrain SSC differentiation through the modulation of GDNF expression—an indication of autocrine regulation. Collectively, our findings illuminate the complex regulatory schema by which SC‐EXOs affect SSC differentiation, offering novel perspectives and laying the groundwork for future preclinical and clinical investigations.
Food‐Drug Effects and Pediatric Drug Development Studies Submitted to the US Food and Drug Administration, 2012‐2022
Authors: Tunehag Kayla R. , George Blessy , Samuels Sherbet , Vo Karen , Arya Vikram , Abulwerdi Gelareh , Burckart Gilbert J. 
Published: January 2024

AbstractFood effect (FE) studies characterize food‐drug interactions that may alter the efficacy or safety of a drug, but these studies are not conducted in pediatric patients. Pediatric patients have substantial physiologic, anatomic, and dietary differences from adults, which may result in differences in their FE considerations. Therefore, the objective of this study was to identify oral drug products approved for use in pediatric patients aged <6 years with an FE observed in adults. Additional objectives were to summarize the therapeutic areas, pharmacokinetic effects, and labeling instructions that resulted from these studies. Publicly available data were searched for products studied in pediatric patients and approved for use by the United States Food and Drug Administration (FDA) from 2012 to 2022. Of the 102 oral drug products approved for use in patients aged <6 years, 43 recommended the consideration of food intake in the drug labeling. These included drug products recommended to be taken with food (n = 21, 49%) or without food (n = 14, 33%). Each of the 14 drug products recommended to be taken without food are approved for use in pediatric patients aged <2 years. The products approved for use in pediatric patients aged <2 years comprised the highest proportion with area under the plasma concentration‐time curve extrapolated to infinity (AUCinf, n = 35, 75%) and maximum serum concentration (Cmax, n = 45, 80%) affected by food. Close monitoring is warranted during the postapproval period for products identified as having a significant FE in adults and that are approved for use in pediatric patients aged <6 years. Promising tools for predicting pediatric FE may include physiologically based pharmacokinetic absorption modeling.
Prevalence and heritability of parental‐reported speech and/or language difficulties in a Swedish population‐based twin sample
Authors: Keijser Rebecka , Åsberg Johnels Jakob , Habbe Marika , Lichtenstein Paul , Larsson Henrik , Lundström Sebastian , Taylor Mark J. , Tammimies Kristiina 
Published: January 2024

AbstractBackgroundResearch on genetic and environmental influences on speech and/or language difficulties (SaLD) is sparse, with inconsistent heritability estimates. We aimed to estimate the prevalence of parental reported SaLD and the relative contributions of genetic and environmental factors for the phenotype using a Swedish population‐based twin sample. We hypothesized that there would be a stronger genetic than environmental effect on SaLD.MethodsData were collected from The Child and Adolescent Twin Study in Sweden. The study sample included 16,774 twin pairs (16,946 males, 16,602 females), of which 5141 were monozygotic, 5861 dizygotic (DZ), and 5772 opposite‐sex DZ pairs. The language items in the Autism–Tics, Attention‐Deficit Hyperactivity Disorder, and other Comorbidities inventory were used to categorize individuals as having parental‐reported SaLD. A classical twin design was used to estimate the relative contribution of genetic and environmental factors to the liability of SaLD.ResultsThe prevalence of SaLD was 7.85% (95% confidence interval (CI) [7.57%–8.15%]) and 7.27% (95% CI [6.99%–7.55%]) when excluding individuals with autism and intellectual disability (ID). We also found that SaLD were significantly more prevalent in males than females with a ratio of 2:1. The heritability was estimated to be 75% (95% CI [67%–83%]) for SaLD. Shared environment played a significant role with an estimated contribution of 22% (95% CI [14%–30%]). The heritability estimate was reduced to 70% but with overlapping CI when excluding individuals with autism and ID.ConclusionsWe provide evidence that SaLD is common in the population and under strong genetic influence. Future studies should focus on mapping the genetic architecture of SaLD and related disorders.
Acclimation of intertidally reproducing sea‐snails protects embryos from lethal effects of transient hyperthermia
Authors: Goulding Morgan Q. 
Published: January 2024

AbstractEmbryos of Ilyanassa obsoleta (from Massachusetts and Florida) and Phrontis vibex (from Florida) were exposed to temperatures from 33 to 37°C. In both species, very young embryos are especially sensitive to thermal stress. Brief early heat shock did not disturb spiral cleavage geometry but led to variable, typically severe defects in larval morphogenesis and tissue differentiation. In Ilyanassa but not P. vibex, early heat shock resulted in immediate slowing or arrest of interphase progression during early cleavage. This reversible arrest was correlated with improved prognosis for larval development and (in Massachusetts snails, at least) depended on parental acclimation to warm temperature (~25.5°C). Embryos from Massachusetts snails housed at lower temperature (16°C) exhibited cytokinesis failure when briefly incubated at 33°C during early cleavage, and tissue differentiation failure during incubation at 33°C begun at later stages. This preliminary study reveals a case in which stress‐conditioned parents may endow embryos with protection against potentially lethal thermal stress during the most vulnerable stages of life.