bluuebunny/crossref_metadata_2025_split huggingface dataset:
Dosimetric evaluation in Helical TomoTherapy for lung SBRT using Monte Carlo‐based independent dose verification software
Authors: Kosaka Takahiro , Takatsu Jun , Inoue Tatsuya , Iijima Kotaro , Suzuki Michimasa , Murakami Naoya , Shikama Naoto 
Published: February 2024

AbstractPurposeTo elucidate the dosimetric errors caused by a model‐based algorithm in lung stereotactic body radiation therapy (SBRT) with Helical TomoTherapy (HT) using Monte Carlo (MC)‐based dose verification software.MethodsFor 38 plans of lung SBRT, the dose calculation accuracy of a treatment planning system (TPS) of HT was compared with the results of DoseCHECK, the commercial MC‐based independent verification software. The following indices were extracted to evaluate the correlation of dosimetric errors: (1) target volume, (2) average computed tomography (CT) value of the planning target volume (PTV) margin, and (3) average CT value of surrounding 2‐mm area of the PTV (PTV ring). Receiver operating characteristic (ROC) analyses determined the threshold for 5% of differences in PTV D95%. Then, the 38 plans were classified into two groups using the cutoff values of ROC analysis for these three indices. Dosimetric differences between groups were statistically compared using the Mann–Whitney U test.ResultsTPS of HT overestimated by more than 5% in the PTV D95% in 16 of 38 plans. The PTV ring showed the strongest correlation with dosimetric differences. The cutoff value for the target volume, the PTV margin, and the PTV ring was 14.7 cc, −754 HU, and −708 HU, respectively. The area under the curve (AUC) for the target volume, the PTV margin, and the PTV ring were 0.835, 0.878, and 0.932, respectively. Dosimetric errors more than 5% were observed when the PTV volume was less than 15 cc or when the CT value around the target was less than −700 HU.ConclusionThe TPS of HT might overestimate the PTV dose by more than 5% if any the three indices in this study were below threshold. Therefore, independent verification with an MC‐based algorithm should be strongly recommended for lung SBRT in HT.
A retrospective study on the investigation of potential dosimetric benefits of online adaptive proton therapy for head and neck cancer
Authors: Chang Chih‐Wei , Bohannon Duncan , Tian Zhen , Wang Yinan , Mcdonald Mark W. , Yu David S. , Liu Tian , Zhou Jun , Yang Xiaofeng 
Published: February 2024

AbstractPurposeProton therapy is sensitive to anatomical changes, often occurring in head‐and‐neck (HN) cancer patients. Although multiple studies have proposed online adaptive proton therapy (APT), there is still a concern in the radiotherapy community about the necessity of online APT. We have performed a retrospective study to investigate the potential dosimetric benefits of online APT for HN patients relative to the current offline APT.MethodsOur retrospective study has a patient cohort of 10 cases. To mimic online APT, we re‐evaluated the dose of the in‐use treatment plan on patients’ actual treatment anatomy captured by cone‐beam CT (CBCT) for each fraction and performed a templated‐based automatic replanning if needed, assuming that these were performed online before treatment delivery. Cumulative dose of the simulated online APT course was calculated and compared with that of the actual offline APT course and the designed plan dose of the initial treatment plan (referred to as nominal plan). The ProKnow scoring system was employed and adapted for our study to quantify the actual quality of both courses against our planning goals.ResultsThe average score of the nominal plans over the 10 cases is 41.0, while those of the actual offline APT course and our simulated online course is 25.8 and 37.5, respectively. Compared to the offline APT course, our online course improved dose quality for all cases, with the score improvement ranging from 0.4 to 26.9 and an average improvement of 11.7.ConclusionThe results of our retrospective study have demonstrated that online APT can better address anatomical changes for HN cancer patients than the current offline replanning practice. The advanced artificial intelligence based automatic replanning technology presents a promising avenue for extending potential benefits of online APT.
Escherichia coli‐Induced cGLIS3‐Mediated Stress Granules Activate the NF‐κB Pathway to Promote Intrahepatic Cholangiocarcinoma Progression
Authors: Kang Feng‐Ping , Chen Zhi‐Wen , Liao Cheng‐Yu , Wu Yong‐Ding , Li Ge , Xie Cheng‐Ke , Lin Hong‐Yi , Huang Long , Tian Yi‐Feng , Wang Zu‐Wei , Chen Shi 
Published: February 2024

AbstractPatients with concurrent intrahepatic cholangiocarcinoma (ICC) and hepatolithiasis generally have poor prognoses. Hepatolithiasis is once considered the primary cause of ICC, although recent insights indicate that bacteria in the occurrence of hepatolithiasis can promote the progression of ICC. By constructing in vitro and in vivo ICC models and patient‐derived organoids (PDOs), it is shown that Escherichia coli induces the production of a novel RNA, circGLIS3 (cGLIS3), which promotes tumor growth. cGLIS3 binds to hnRNPA1 and G3BP1, resulting in the assembly of stress granules (SGs) and suppression of hnRNPA1 and G3BP1 ubiquitination. Consequently, the IKKα mRNA is blocked in SGs, decreasing the production of IKKα and activating the NF‐κB pathway, which finally results in chemoresistance and produces metastatic phenotypes of ICC. This study shows that a combination of Icaritin (ICA) and gemcitabine plus cisplatin (GP) chemotherapy can be a promising treatment strategy for ICC.
Self‐Assembling Anti‐Freezing Lamellar Nanostructures in Subzero Temperatures
Authors: Yin Hongyao , Guo Weiluo , Wang Runxi , Doutch James , Li Peixun , Tian Qiang , Zheng Zhuo , Xie Lingzhi , Feng Yujun 
Published: February 2024

AbstractThe requirement for cryogenic supramolecular self‐assembly of amphiphiles in subzero environments is a challenging topic. Here, the self‐assembly of lamellar lyotropic liquid crystals (LLCs) are presented to a subzero temperature of −70 °C. These lamellar nanostructures are assembled from specifically tailored ultra‐long‐chain surfactant stearyl diethanolamine (SDA) in water/glycerol binary solvent. As the temperature falls below zero, LLCs with a liquid‐crystalline Lα phase, a tilted Lβ phase, and a new folded configuration are obtained consecutively. A comprehensive experimental and computational study is performed to uncover the precise microstructure and formation mechanism. Both the ultra‐long alkyl chain and head group of SDA play a crucial role in the formation of lamellar nanostructures. SDA head group is prone to forming hydrogen bonds with water, rather than glycerol. Glycerol cannot penetrate the lipid layer, which mixes with water arranging outside of the lipid bilayer, providing an ideal anti‐freezing environment for SDA self‐assembly. Based on these nanostructures and the ultra‐low freezing point of the system, a series of novel cryogenic materials are created with potential applications in extremely cold environments. These findings would contribute to enriching the theory and research methodology of supramolecular self‐assembly in extreme conditions and to developing novel anti‐freezing materials.
A Bioinspired Shape Memory Alloy Based Soft Robotic System for Deep‐Sea Exploration
Authors: Xu Yi , Zhuo Jiangshan , Fan Mingyu , Li Xinge , Cao Xunuo , Ruan Dongrui , Cao Hejinsheng , Zhou Fanghao , Wong Tuck‐Whye , Li Tiefeng 
Published: February 2024

Developing robots integrating sensors, actuators, and computational capabilities for deep‐sea exploration is challenging. Nature often offers innovative solutions to complex problems, and in this context, inspiration is drawn from the remarkable abilities of deep‐sea snails, specifically their unique tentacles, often referred to as “eyestalks” due to the presence of an eye at their tip. Herein, “DeepStalk,” a soft robot designed for deep‐sea exploration, is introduced, utilizing three shape memory alloys (SMAs) springs that mimic the three tentacle flexor muscles of deep‐sea snails. Overall, DeepStalk incorporates sensory, actuation, and control modules for operation under high hydrostatic pressure. To achieve precise control of its orientation in 3D space, a simple and reliable vector‐PID controller is developed. Remarkably, the robot successfully maintains its desired bending attitude even at 30 MPa hydrostatic pressure, achieved through the Joule heating of SMA springs. Furthermore, DeepStalk demonstrates the capability to track moving objects underwater, showcasing its potential application in challenging environments at depths of up to 20 MPa. This marks the first attempt for soft robots to integrate sensor, actuator, and control modules capable of complex tasks under high hydrostatic pressure. This innovative research advances integrated soft robotic systems for deep‐sea exploration field.
Sparse multiway canonical correlation analysis for multimodal stroke recovery data
Authors: Das Subham , West Franklin D. , Park Cheolwoo 
Published: February 2024

AbstractConventional canonical correlation analysis (CCA) measures the association between two datasets and identifies relevant contributors. However, it encounters issues with execution and interpretation when the sample size is smaller than the number of variables or there are more than two datasets. Our motivating example is a stroke‐related clinical study on pigs. The data are multimodal and consist of measurements taken at multiple time points and have many more variables than observations. This study aims to uncover important biomarkers and stroke recovery patterns based on physiological changes. To address the issues in the data, we develop two sparse CCA methods for multiple datasets. Various simulated examples are used to illustrate and contrast the performance of the proposed methods with that of the existing methods. In analyzing the pig stroke data, we apply the proposed sparse CCA methods along with dimension reduction techniques, interpret the recovery patterns, and identify influential variables in recovery.
A generalized calibrated Bayesian hierarchical modeling approach to basket trials with multiple endpoints
Authors: Chi Xiaohan , Yuan Ying , Yu Zhangsheng , Lin Ruitao 
Published: February 2024

AbstractA basket trial simultaneously evaluates a treatment in multiple cancer subtypes, offering an effective way to accelerate drug development in multiple indications. Many basket trials are designed and monitored based on a single efficacy endpoint, primarily the tumor response. For molecular targeted or immunotherapy agents, however, a single efficacy endpoint cannot adequately characterize the treatment effect. It is increasingly important to use more complex endpoints to comprehensively assess the risk–benefit profile of such targeted therapies. We extend the calibrated Bayesian hierarchical modeling approach to monitor phase II basket trials with multiple endpoints. We propose two generalizations, one based on the latent variable approach and the other based on the multinomial–normal hierarchical model, to accommodate different types of endpoints and dependence assumptions regarding information sharing. We introduce shrinkage parameters as functions of statistics measuring homogeneity among subgroups and propose a general calibration approach to determine the functional forms. Theoretical properties of the generalized hierarchical models are investigated. Simulation studies demonstrate that the monitoring procedure based on the generalized approach yields desirable operating characteristics.
Spectrum–effect relationship study between ultra‐high‐performance liquid chromatography fingerprints and anti‐hepatoma effect in vitro of Cnidii Fructus
Authors: Lv Zhenguo , Ouyang Huizi , Zuo Fanjiao , Ge Minglei , Wu Mengxuan , Zhao Lulu , Zhu Yameng , Miao Xinxin , Bai Yu , Chang Yanxu , He Jun 
Published: February 2024

AbstractCnidii Fructus, derived from the dried ripe fruit of Cnidium monnieri (L.) Cuss, has the effect of warming kidneys and invigorating Yang. This study established the spectrum–effect relationships between ultra‐high‐performance liquid chromatography (UHPLC) fingerprints and the antitumor activities of Cnidii Fructus on human hepatocellular carcinoma (HepG2) cells. In UHPLC fingerprints, 19 common peaks were obtained, and 17 batches of herbs had similarity >0.948. In Cell Counting Kit‐8 (CCK‐8) test, 17 batches of Cnidii Fructus extract significantly inhibited the proliferation of HepG2 cells to different degrees, showing different half‐maximal inhibitory concentration (IC50) values. Furthermore, gray correlation analysis, Pearson's analysis, and orthogonal partial least squares discriminant analysis were performed to screen out eight components. The analysis of mass spectrum data and a comparison with standards revealed that the eight components were methoxsalen, isopimpinellin, osthenol, imperatorin, osthole, ricinoleic acid, linoleic acid, and oleic acid. The verification experiments by testing single compounds indicated that these eight compounds were the major anti‐hepatoma compounds in Cnidii Fructus. This work provides a model combining UHPLC fingerprints and antitumor activities to study the spectrum–effect relationships of Cnidii Fructus, which can be used to determine the principal components responsible for the bioactivity.
Investigation of the therapeutic effect of Hedan tablets on high‐fat diet‐induced obesity in rats by GC–MS technology and 16S ribosomal RNA gene sequencing
Authors: Pan Xuan , Zhang Yumeng , Qiao Yongyao , Cao Qingying , Wei Liuxin , Zhao Min 
Published: February 2024

AbstractObesity is a persistent metabolic condition resulting from the excessive accumulation or abnormal distribution of body fat. This study aimed to establish an experimental rat model of obesity. The efficacy of treating obesity with Hedan tablets (HDT) was assessed by monitoring changes in weight, blood lipid levels, analyzing inflammatory factors, evaluating organ indices, and observing liver tissue pathology. Furthermore, we utilized 16S ribosomal RNA gene sequencing technology to explore changes in intestinal flora. In addition, GC–MS was used to measure fecal short‐chain fatty acid (SCFA) content. The onset of obesity led to a significant decrease in the relative abundance of beneficial bacteria. Conversely, the administration of HDT demonstrated a substantial ability to increase the relative abundance of beneficial bacteria. Obesity resulted in a noteworthy reduction in total SCFAs, a trend significantly reversed in the HDT group. Through correlation analysis, it was determined that HDT mitigated the inflammatory response and improved blood lipid levels by augmenting the abundance of Lactobacillus, Limosilactobacillus, Ruminococcus, and Enterococcus. These particular intestinal flora were identified as regulators of SCFA metabolism, thereby ameliorating metabolic abnormalities associated with obesity. Moreover, HDT intervention elevated the overall fecal concentration of SCFAs, thereby improving metabolic disorders induced by obesity. The anti‐obesity effects of HDT are likely attributable to their capacity to influence the composition of intestinal flora and boost SCFA levels in the intestine.
Do boards care about planetary boundaries? A gender perspective on circular economy disclosures
Authors: Enciso‐Alfaro Saudi‐Yulieth , García‐Sánchez Isabel‐María 
Published: February 2024

AbstractThe need to develop environmentally respectful business activities has led academics to propose the circular economy (CE) as a more sustainable production and consumption model than the linear model, where interest groups demand greater disclosure of information that makes it possible to evaluate the business transition towards the CE. Also, the planetary boundaries framework provides thresholds for different natural processes that are affected by business activities, so in this research, we link the CE to planetary boundaries by designing a score, and we analyse the presence of female directors and the role women play in the presentation of CE information that attends to planetary boundaries. We also examine the effect that national cultures characterized by high power distance and masculinity can have on their performance. We use a sample of 832 companies around the world from 2011 to 2020. The results show that women directors promote the presentation of CE information at a global level and disaggregated by CE issues, framed within planetary boundaries—a relation that is reinforced in societies with high power distance.
“How I think, Who I am”—Role of social media influencers (SMIs) as change agents
Authors: Paul Justin , Jagani Khyati , Yadav Neha 
Published: February 2024

AbstractSocial media influencers (SMIs) have gained critical standing due to their capability to generate trust and alter behaviors. Trust in the influencer has further encouraged the followers to value the relationship equally and sometimes more than family and friends. In a mixed‐method approach, the study investigates the role played by SMIs as change agents by generating trust. Partial least square structural equation modeling (PLS‐SEM) was used to assess the measurement and structural models. Findings reveal that influencer characteristics—interactivity and informativeness—significantly impact the followers' social, physical, and emotional self‐concept. Trust fully mediated the relationship between interactivity and emotional self‐concept, and partially mediated the relationship between interactivity and social & physical self‐concept. However, informativeness was not significant in building trust leading to self‐concept. The findings imply that SMIs must engage in more consistent, meaningful, and real conversations with their followers to create an effective communication strategy. The current study based on the findings develops a conceptual model to demonstrate the impact of SMI characteristics on self‐concept, by generating trust.
Children and adolescent consumer behavior: Insights from the life course paradigm
Authors: Moschis George P. , Mathur Anil 
Published: February 2024

AbstractResearchers have long been interested in understanding young consumers, but they have had inadequate methods for studying their consumption‐related thoughts and actions at early stages of life and how these develop and change during formative years. Recent theoretical and methodological advances in behavioral and social science have contributed to the development of a research approach, known as “life course paradigm.” This approach has helped replace and integrate previously used theories and methods by offering researchers an over‐arching multi‐theoretical framework for studying a wide variety of phenomena; and it has rapidly diffused across disciplines, and is increasingly used internationally. This article shows how consumer researchers could benefit from applying this conceptual research framework to improve existing models and study youths' consumer behavior in an innovative way.
Adenoid cystic carcinoma of distal trachea: A case report
Authors: Choi Sang Gyu 
Published: February 2024

Key Clinical MessageThis case report highlights the rarity of distal tracheal adenoid cystic carcinoma and emphasizes the importance of considering it as a differential diagnosis in patients presenting with sustained dyspnea. Early diagnosis and a multidisciplinary approach involving thoracic surgeons, radiation oncologists, and medical oncologists are crucial for optimal treatment planning and patient outcomes. Further research is warranted to better understand the pathogenesis, molecular characteristics, and optimal management strategies for this rare tracheal malignancy.AbstractAdenoid cystic carcinoma (ACC) is an unusual malignant neoplasm that mostly arises in the minor salivary glands. It can also occur in various mucous membrane‐lined structures, including the trachea. The treatment of choice is surgery in resectable cases, but radiotherapy and chemotherapy are generally utilized for unresectable cases or palliative treatment. In this study, I report my experience with a case of unresectable ACC occurring in a distal trachea treated with concurrent chemoradiotherapy (CCRT), based on the patient's clinical presentation, diagnostic workup, histopathological findings, treatment modalities, and long‐term prognosis.
Efficacy and manageable safety of tagraxofusp in blastic plasmacytoid dendritic cell neoplasm: a case series of pediatric and adolescent/young adult patients
Authors: Pemmaraju Naveen , Cuglievan Branko , Lasky Joseph , Kheradpour Albert , Hijiya Nobuko , Stein Anthony S. , Meshinchi Soheil , Mullen Craig A. , Angelucci Emanuele , Vinti Luciana , Mughal Tariq I. , Pawlowska Anna B. 
Published: February 2024

AbstractBlastic plasmacytoid dendritic cell neoplasm (BPDCN) predominantly occurs in adults ≥60 years old; 10–20% of cases are pediatric or adolescent/young adult (AYA) patients. Tagraxofusp (TAG, Elzonris®) is the only approved treatment for BPDCN; in the United States it is approved for patients aged ≥2 years. Data on treating pediatric and AYA BPDCN patients are limited. We present a case series of pediatric and AYA patients with BPDCN treated with TAG. Eight patients (five newly diagnosed; three relapsed/refractory [R/R]), aged 2–21 years, received 12 mcg/kg TAG. Seven patients were female; most had skin (n = 6) and/or bone marrow (n = 4) involvement. No new safety signals were identified. Grade 3 adverse events were headache (n = 1) and transaminitis (n = 2). Three patients with newly diagnosed BPDCN achieved complete response, one achieved partial response, and one had stable disease (SD). One patient with R/R BPDCN achieved a minor response; one had SD. Seven patients (88%) were bridged to stem cell transplant: 80% of newly diagnosed patients and 100% of R/R patients. Five patients remained alive at last follow‐up. These cases highlight the efficacy and safety of TAG in pediatric and AYA patients for whom there is no other approved BPDCN therapy.
Association between venous thromboembolism‐associated genetic variants, coagulation factor levels, and thrombin generation potential
Authors: Han Jihee , Li‐Gao Ruifang , de Mutsert Renée , Rosendaal Frits R. , van Hylckama Vlieg Astrid 
Published: February 2024

AbstractRecently three large meta‐analyses of genome‐wide association studies for venous thromboembolism (VTE) identified over 130 genetic variants. However, mechanisms by which newly identified and therefore underexplored VTE‐associated genetic variants influence VTE remain unclear. To elucidate the mechanism, we investigated the association between 61 newly identified VTE‐associated genetic variants and the levels of coagulation factor (F) VIII, FIX, FXI, and fibrinogen as well as thrombin generation parameters (lag time, peak, endogenous thrombin potential, time‐to‐peak, and velocity), which are well‐known biological traits associated with VTE. This study was conducted on 5341 participants of the Netherlands Epidemiology of Obesity study. The associations between VTE‐associated genetic variants and coagulation factor levels and thrombin generation parameters were examined using linear regression analyses, adjusted for age, sex, body mass index, oral contraceptive use, hormone replacement therapy, and menopausal status. Of 61 genetic variants, 33 were associated with one or more of the coagulation factor levels and thrombin generation parameters. Following multiple testing corrections, five genetic variants remained significant, of which MAP1A rs55707100 exhibited the most robust association with thrombin generation parameters and FXI levels (β = ‐5.33%, 95% confidence interval: ‐8.44, ‐2.22). Our findings shed light on the underlying mechanisms by which these genetic variants influence the risk of VTE.