bluuebunny/crossref_metadata_2025_split huggingface dataset:
Abstract PR004: Interplay between histone modifications and DNA methylation in cancer
Authors: Lu Chao 
Published: February 2025

Abstract
During solid tumor development, gene-poor and lamina-associated genomic regions undergo progressive loss of DNA methylation, whereas promoter CpG islands become DNA hypermethylated. We report evidence suggesting that the recruitment of DNMT3A by histone modifications contributes to this cancer-associated DNA methylome reprogramming. The genomic targeting of DNMT3A is regulated by the competition between NSD1-mediated histone H3K36 methylation and polycomb-mediated H2AK119 ubiquitination, via DNMT3A's PWWP domain and N-terminal ubiquitin-interacting region, respectively. Mutations in NSD1, DNMT3A reader domains or polycomb complexes perturb DNMT3A recruitment and can recapitulate patterns of DNA methylation observed in patient tumors. Lastly, tumors exhibiting progressive hypomethylation, such as those harboring NSD1 mutations, are paradoxically immune-cold despite the increased expression of retrotransposons. These results suggest that DNA hypomethylation and aberrant retrotransposon activation are significant bottlenecks to tumor development and may represent promising therapeutic targets.
Citation Format: Chao Lu. Interplay between histone modifications and DNA methylation in cancer [abstract]. In: Proceedings of the AACR Special Conference in Cancer Research: DNA Methylation, Clonal Hematopoiesis, and Cancer; 2025 Feb 1-4; San Diego, CA. Philadelphia (PA): AACR; Cancer Res 2025;85(3 Suppl):Abstract nr PR004.
God, the Feminine, and Other Struggles
Authors: Verde Danilo 
Published: February 2025

Abstract
This review examines three recent contributions to the Song of Songs scholarship by Nina S. Heereman, Vita Daphne Arbel, and Elaine T. James & Simeon B. Chavel, each offering fresh perspectives on this celebrated biblical poem. Heereman proposes a symbolic interpretation that integrates anthropological and theological dimensions. Focusing on the “most beautiful woman,” Arbel applies gender studies to explore the poem’s complex and fluid depictions of femininity. James and Chavel, inspired by the MeToo movement, connect the Song to contemporary debates on gender, power, and violence, with several chapters offering a reparative reading. Together, these works highlight the Song’s unique ability to inspire dialogue across multiple fields, demonstrating how both the text itself and the conceptual frameworks of its readers contribute to its rich interpretive possibilities.
dumu diĝir-ra-na: Divine Filiation in Mesopotamian Incantation Literature
Authors: Agnethler Hannelore , Baragli Beatrice 
Published: February 2025

Abstract
This article tackles the question of divine filiation in the ancient Near East, analysing the Sumerian phrase dumu diĝir-ra-na “the child of his/her god.” This characteristic phrase appears almost exclusively within incantation literature and designates the patient. The article proposes that this phrase implies a specific kind of relationship between the patient and his “personal god(s)” and traces the historical development of the phrase by comparing an up-to-date collection of attestations (included as an appendix) with other phrases indicating the patient in Sumerian and Akkadian sources. The article concludes that dumu diĝir-ra-na first occurs in the Old Babylonian period and is distinct from other terms for patients in that it stresses reconciliation between the patient and the personal god as necessary for the patient’s healing. Texts that include this phrase and express the concept of reconciliation employ a rhetoric that relates a specific role to each speaker.
American Abortion Culture Wars as Religious Populism: “Truth” and “Fight for Truth” as Floating Signifiers
Authors: Oh Dayei 
Published: February 2025

Abstract
This paper explores the American abortion culture wars through the lens of religious populism, focusing on online discourse of the Christian pro-life confederation, Personhood Alliance. Drawing on Laclaudian post-foundationalist theories, the paper conceptualizes culture wars as a populist logic of meaning-making, where the floating signifier “truth” is central to mobilizing support and constructing Us-Them boundaries. The analysis identifies two key floating meanings of “truth”: restoring divine, cultural, and scientific truth about personhood, and battling the perceived conspiracies of the liberal abortion establishment. Hybrid media ecologies provide a controlled space for the movement to disseminate narratives circumventing platform moderation. The movement’s affective Us-Them construction portrays “Us” as righteous truth-seekers and saviours of the marginalized, while “Them” is cast as a corrupt liberal elite deceiving and exploiting the marginalised. This affective dichotomy expands abortion culture wars beyond the Christian pro-life base, inviting marginalized groups to join the fight against the establishment.
A Populist, Influencer, and Religious Politician
Authors: Vuković Silvija , Krapić Nina 
Published: February 2025

Abstract
Celebrity populism describes a combination of populism and celebrity politics in contemporary political communication. This paper narrows the concept down, as we present what we recognize as a populist influencer politician – a populist politician who is performing in a style of an influencer. Moreover, we analyze a specific role religion plays in the construction of populist messages. The empirical part centers on Marin Miletić, a populist politician and former religion teacher from Croatia who is communicating as an influencer on social media. Qualitative content analysis of Miletić’s Instagram Stories during the Croatian parliamentary election campaign in 2024 unravels how he combines political, religious, and private personas on social media. The paper provides detailed examples of how influencer style and religion content emphasize his populist messages. At the same time, we shed light on the blurred lines between entertainment, politics, populism, and religion in contemporary political communication.
#Girlhood: Why Memetic Aesthetics of Hyperfemininity Matter for Feminist Media Studies
Authors: Wiens Brianna I. , McWebb Anna 
Published: February 2025

Abstract
There is a pressing need to focus attention on hyperfemininity as a valid and valued form of gender expression and feminist protest within contemporary social media. As resistance against the heteropatriarchal gender expectations that influence femininity and that produce femmephobia, we focus our analysis on the social media #girlhood meme trend that, we suggest, embraces a wide range of femme practices through the re-mixing of fem(me)ininity and femme-ness, while critiquing heteropatriarchal norms. We trace the circulation of #girlhood, including coquette aesthetics, #barbiecore, and #bimbofeminism, outlining how these playful expressions of femininity contribute to subverting expectations of “successful” femme bodies. We argue that if gender norms are scripts that prescribe and describe how we must act, then widening the range of acceptable feminine behaviour through hyperfemininity, as manifest in #girlhood memes, is crucial for changing how we discipline femme bodies and how we analyze femininity within media studies.
Improving power system performance by integrating TCSC and SVC devices in the presence of stochastic renewable energy generators
Authors: Benhabsa Imadeddine , Kouadri Ramzi , Slimani Linda , Mouassa Souhil 
Published: February 2025

This paper investigates the application of advanced metaheuristic algorithms Blood-Sucking Leech Optimizer (BSLO), Bonobo Optimizer (BO), and Electric Eel Foraging Optimization (EEFO) to solve the optimal power flow (OPF) problem with stochastic renewable energy generators (REGs), specifically photovoltaic power generators (PVGs) and wind power generators (WGs). Two scenarios are examined: Scenario 1 evaluates the proposed algorithms performance without Flexible AC Transmission Systems (FACTS), focusing on minimizing Total Generation Cost (TGC), Active Power Loss (APL), and a combined objective of TGC and Emissions (TGCE). The TGC including both thermal and REG costs, in which the cost related to stochastic PV and wind power generation encompasses direct, reserve, and penalty costs due to overestimation and underestimation of available PV and wind power. Scenario 2 introduces the Thyristor-Controlled Series Capacitor (TCSC) and the Static Var Compensator (SVC) to evaluate their impact on three objective functions. The performance of the algorithms is evaluated on a modified IEEE 30-bus system. The results show that the BSLO algorithm consistently achieves the best TGC, APL, and TGCE values at 781.1209 $/h, 1.9960 MW, and 810.7376 $/h, respectively. These outcomes highlight its effectiveness and competitive performance in the first scenario. The integration of FACTS devices in the second scenario results in a 6.73% reduction in APL with the insertion of TCSC, a 1.86% reduction with the insertion of SVC, and a 6.10% reduction with the insertion of both TCSC and SVC, compared to the APL value in the case without FACTS devices (1.9960 MW). The study comprehensively analyzes how different optimization techniques and FACTS devices enhance power system performance with stochastic REG integration.
Dual jeopardy for Indian service users: Qualitative study of managing comorbid schizophrenia and diabetes mellitus
Authors: Pavagada Rajendra , Ko Kitty S. W. , Lai Simon , Zeng Irene , Sanchez Denisse , Ng Lillian 
Published: February 2025

Objective Diabetes mellitus is a sequelae of antipsychotic medication in people of Indian descent with schizophrenia. The Indian socio-cultural context amplifies challenges of managing chronic illness. The aim of this study was to explore Indian mental health service users’ perspectives of managing comorbid psychosis and diabetes mellitus, specifically culture-related difficulties. Methods In this exploratory study, people with an Indian cultural background recruited from community mental health clinics were interviewed by an Indian psychiatrist using a semi-structured questionnaire. Interviews were professionally transcribed. Reflexive thematic analysis was used to develop central organising concepts and identify themes. Results Four themes were identified: culture-specific views on comorbidity, preferences for tailoring education to Indian language and culture, changes in interpersonal relationships within extended family and relationships with healthcare professionals. Advice from hospital services was not specific to Indian culture and there were wider impacts of illness for wider family. Conclusion Indian New Zealanders have challenges in managing dual mental and physical illnesses. Further research is needed to develop approaches to care that emphasise service users’ culture as core to understanding illness and treatment. This includes consideration of gender roles, families, communities, food, language, lifestyle and barriers to treatment.
EXPRESS: Unlocking the Immune Puzzle: T Cell exhaustion in cirrhosis and implication for immunotherapy
Authors: Yadav Geeta , Goel Amit , Kumar Manish , Malhotra Hardeep , Katiyar Harshita , dandu Himanshu 
Published: February 2025

Background: Cirrhosis, an advanced stage of liver diseases, induces Cirrhosis-Associated Immune Dysfunction Syndrome (CAIDS) characterized by both innate and adaptive immune dysfunction. Inflammation triggered by factors such as alcohol, viruses, toxins, and cholesterol induce metabolic reprogramming of both innate and adaptive immune cells. Our study specifically sought to investigate the compromised adaptive immune response in cirrhosis by focusing on assessing T-cell exhaustion and activation markers on helper and cytotoxic T cells. Method: A prospective observational study involving 19 liver cirrhosis patients and 36 healthy controls was conducted. Hepatic decompensation degree was assessed using various parameters including serum bilirubin, albumin, international normalized ratio, ascites and hepatic encephalopathy. T cell activation (CD38, CD44, CD69, HLADR), and exhaustion markers (CTLA-4, PD-1, TIM-3, LAG-3) were assessed on helper and cytotoxic T cells by flow cytometry. Result: Cirrhosis patients showed reduced T cells with no alteration in CD4:CD8 T cell ratio. Among activation markers, HLADR showed increased expression on CD8+ T cells (P=0.031). Regarding exhaustion markers LAG-3 and TIM-3 exhibited increased expression in cirrhotic patients compared to controls in both CD4 and CD8 T cells (P=0.004, P=0.016, P=0.001, P=0.004, respectively). Neither cirrhotic nor healthy controls showed CTLA expression. PD-1 did not differ significantly between the two groups. Co-expression of PD-1/TIM-3 on CD8+ T cells was notably higher in cirrhotic patients (P<0.002). Conclusion: The observation of impaired adaptive immunity with notable T cell exhaustion and activation in cirrhosis underscores the potential relevance of immunotherapy.
Impact of antimicrobial stewardship interventions on post-elective caesarean antibiotic prophylaxis and surgical site infections
Authors: Seah Valerie Xue Fen , Ong Rina Yue Ling , Poh Cedric Wei Ming , Kam Kai Qian , Siraj Shahul Hameed Mohamed , Thoon Koh Cheng 
Published: February 2025

Background Antimicrobial stewardship programs (ASP) aim to improve appropriate antimicrobial use but few studies have described its impact on unique population such as obstetrics. Post-operative antibiotics are unnecessary especially in those without surgical site infections (SSI) risk factors (e.g., obesity). Objectives To evaluate the impact of ASP interventions on post-elective caesarean (eLSCS) oral antibiotic prophylaxis rates and patient outcomes. Methods This pre-post quasi-experimental study was conducted over 18 months (2 months pre- and 16 months post-intervention) in all women admitted for eLSCS in our institution. Interventions included eLSCS surgical prophylaxis guideline dissemination and post-eLSCS oral antibiotics was actively discouraged in those without SSI risk factors. This was followed by ASP intervention notes (phase 1) for 3 months, contacting the ward team for the next 7 months (phase 2) and subsequently the primary obstetrics attending in Phase 3 (next 6 months). The primary outcome was post-operative oral antibiotics prescription rates, and secondary outcomes included 30-day post-operative SSI rates. Results A total of 1751 women was reviewed. Appropriateness of pre-operative antibiotic prophylaxis was 99%. There were 244 (13.9%) women pre-intervention and 1507 (86.1%) post-intervention. Post-eLSCS antibiotic prescribing rates reduced significantly post-intervention (200, 82% vs 705, 46.8%, p < 0.001). There was no significant difference in SSI rates pre-post intervention (2, 0.8% vs 28, 1.9%, p = 0.420). There was also no significant difference in SSI rates among those who received post-operative oral antibiotics compared to those without (1.9%, 17 of 905 vs 1.5%, 13 of 846, p = 0.582). Conclusions ASP interventions can reduce unnecessary post-eLSCS antibiotic prophylaxis use without adversely impacting patient safety.
Building ADMISSION – A research collaborative to transform understanding of multiple long-term conditions for people admitted to hospital
Authors: Witham Miles D , Bartle Victoria , Bellass Sue , Bunn Jonathan G , Cartner Duncan , Cordell Heather J , Doal Rominique , Evison Felicity , Gallier Suzy , Harris Steve , Hillman Susan J , Holding Ray , Leroux Peta , Marshall Tom , Matthews Fiona E , Missier Paolo , Nair Anand , Osman Mo , Pearson Ewan R , Plummer Chris , Pretorius Sara , Richardson Sarah J , Robinson Sian M , Sapey Elizabeth , Scharf Thomas , Shah Rupal , Shahmandi Marzieh , Singer Mervyn , Suklan Jana , Wason James MS , Cooper Rachel , Sayer Avan A 
Published: February 2025

Background Multiple long-term conditions (MLTCs; commonly referred to as multimorbidity) are highly prevalent among people admitted to hospital and are therefore of critical importance to hospital-based healthcare systems. To date, most research on MLTCs has been conducted in primary care or the general population with comparatively little work undertaken in the hospital setting. Purpose To describe the rationale and content of ADMISSION: a four-year UK Research and Innovation and National Institute of Health and Care Research funded interdisciplinary programme that seeks, in partnership with public contributors, to transform care for people living with MLTCs admitted to hospital. Research design Based across five UK academic centres, ADMISSION combines expertise in clinical medicine, epidemiology, informatics, computing, biostatistics, social science, genetics and care pathway mapping to examine patterns of conditions, mechanisms, consequences and pathways of care for people with MLTCs admitted to hospital. Data collection The programme uses routinely collected electronic health record data from large UK teaching hospitals, population-based cohort data from UK Biobank and routinely collected blood samples from The Scottish Health Research Register and Biobank (SHARE). These approaches are complemented by focused qualitative work exploring the perspectives of healthcare professionals and the lived experience of people with MLTCs admitted to hospital. Conclusion ADMISSION will provide the necessary foundations to develop novel ways to prevent and treat MLTCs and their consequences in people admitted to hospital and to improve care systems and the quality of care for this underserved group.
A Preamble to Prevention of Adolescent Substance Use: Pediatric Resident Screening for Caregiver Substance Use
Authors: Calihan Jessica B. , Jinks-Chang Samara , Mark Tiffany , Alinsky Rachel , Adger Hoover , Matson Pamela A. 
Published: February 2025

Background: Caregiver problematic substance use (SU) is a common adverse childhood experience that is associated with the development of SU disorders in adolescence and poor health outcomes. Most pediatricians do not currently screen for caregiver SU, missing an opportunity to provide targeted prevention counseling to at-risk youth and their families. The objective of this study was to assess whether pediatric residents’ screening-related competencies, beliefs, and training were associated with current screening practices and/or preparedness to screen in the future. Methods: Baseline surveys from a quality improvement initiative to increase screening for household SU in pediatric primary care were e-mailed to all pediatric residents at an academic medical center. Surveys assessed residents’ current screening practices, preparedness to screen in the future, screening-related competencies, receipt of SU training, beliefs about screening, perceived caregiver acceptability of screening, and stigma about caregiver SU. Results: Residents agreed screening for household SU is a pediatrician’s responsibility and beneficial for patients and families, yet only 5% universally screened. Preparedness to screen in the future was positively associated with reported screening-related competencies and receipt of training on SU screening during residency. Conclusions: Most residents did not universally screen for household SU, thereby missing opportunities for targeted secondary prevention of adolescent SU. Trained residents who reported competence in addressing families’ concerns were more likely to feel prepared to screen in the future, suggesting education that addresses caring for affected families, reviews available resources, and improves pediatrician confidence may be particularly impactful.
Genome-wide association mapping and genomic prediction analyses reveal the genetic architecture of grain yield and agronomic traits under drought and optimum conditions in maize
Authors: Amadu Manigben Kulai , Beyene Yoseph , Chaikam Vijay , Tongoona Pangirayi B. , Danquah Eric Y. , Ifie Beatrice E. , Burgueno Juan , Prasanna Boddupalli M. , Gowda Manje 
Published: February 2025

Abstract

Background
Drought is a major abiotic stress in sub-Saharan Africa, impacting maize growth and development leading to severe yield loss. Drought tolerance is a complex trait regulated by multiple genes, making direct grain yield selection ineffective. To dissect the genetic architecture of grain yield and flowering traits under drought stress, a genome-wide association study (GWAS) was conducted on a panel of 236 maize lines testcrossed and evaluated under managed drought and optimal growing conditions in multiple environments using seven multi-locus GWAS models (mrMLM, FASTmrMLM, FASTmrEMMA, pLARmEB, pKWmEB, ISIS EM-BLASSO, and FARMCPU) from mrMLM and GAPIT R packages. Genomic prediction with RR-BLUP model was applied on BLUEs across locations under optimum and drought conditions.

Results
A total of 172 stable and reliable quantitative trait nucleotides (QTNs) were identified, of which 77 are associated with GY, AD, SD, ASI, PH, EH, EPO and EPP under drought and 95 are linked to GY, AD, SD, ASI, PH, EH, EPO and EPP under optimal conditions. Among these QTNs, 17 QTNs explained over 10% of the phenotypic variation (R

2
≥ 10%). Furthermore, 43 candidate genes were discovered and annotated. Two major candidate genes, Zm00001eb041070 closely associated with grain yield near peak QTN, qGY_DS1.1 (S1_216149215) and Zm00001eb364110 closely related to anthesis-silking interval near peak QTN, qASI_DS8.2 (S8_167256316) were identified, encoding AP2-EREBP transcription factor 60 and TCP-transcription factor 20, respectively under drought stress. Haplo-pheno analysis identified superior haplotypes for qGY_DS1.1 (S1_216149215) associated with the higher grain yield under drought stress. Genomic prediction revealed moderate to high prediction accuracies under optimum and drought conditions.

Conclusion
The lines carrying superior haplotypes can be used as potential donors in improving grain yield under drought stress. Integration of genomic selection with GWAS results leads not only to an increase in the prediction accuracy but also to validate the function of the identified candidate genes as well increase in the accumulation of favorable alleles with minor and major effects in elite breeding lines. This study provides valuable insight into the genetic architecture of grain yield and secondary traits under drought stress.
Comparison of airway pressure release ventilation (APRV) versus biphasic positive airway pressure (BIPAP) ventilation in COVID-19 associated ARDS using transpulmonary pressure monitoring
Authors: Stoll Sandra Emily , Leupold Tobias , Drinhaus Hendrik , Dusse Fabian , Böttiger Bernd W. , Mathes Alexander 
Published: February 2025

Abstract

Background
APRV has been used for ARDS in the past. Little is known about the risk of ventilator- induced lung- injury (VILI) in APRV vs. BIPAP in the management of in COVID19-associated ARDS (CARDS). This study aimed to compare transpulmonary pressures (TPP) in APRV vs. BIPAP in CARDS in regard to lung protective ventilator settings.

Methods
This retrospective, monocentric cohort study (ethical approval: 21-1553) assessed all adult ICU- patients with CARDS who were ventilated with BIPAP vs. APRV and monitored with TPP from 03/2020 to 10/2021. Ventilator-settings / -pressures, TPP, hemodynamic and arterial blood gas parameters were compared in both modes.

Results
20 non- spontaneously breathing patients could be included in the study: Median TPPendexpiratory was lower / negative in APRV (-1.20mbar; IQR − 4.88 / +4.53) vs. positive in BIPAP (+ 3.4mbar; IQR + 1.95 / +8.57; p < .01). Median TPPendinspiratory did not differ. In APRV, mean tidal- volume per body- weight (7.05 ± 1.28 vs. 5.03 ± 0.77 ml; p < .01) and mean airway- pressure (27.08 ± 1.67 vs. 22.68 ± 2.62mbar; p < .01) were higher. There was no difference in PEEP, peak-, plateau- or driving- pressure, compliance, oxygenation and CO2- removal between both modes.

Conclusion
Despite higher tidal- volumes / airway-pressures in APRV vs. BIPAP, TPPendinspiratory was not increased. However, in APRV median TPPendexpiratory was negative indicating an elevated risk of occult atelectasis in APRV- mode in CARDS. Therefore, TPP- monitoring could be a useful tool for monitoring a safe application of APRV- mode in CARDS.