bluuebunny/crossref_metadata_2025_split huggingface dataset:
Reliability and Operation Cost of Underdamped Memories during Cyclic Erasures
Authors: Dago Salambô , Ciliberto Sergio , Bellon Ludovic 
Published: October 2023

AbstractThe reliability of fast repeated erasures is studied experimentally and theoretically in a 1‐bit underdamped memory. The bit is encoded by the position of a micro‐mechanical oscillator whose motion is confined in a double well potential. To contain the energetic cost of fast erasures, a resonator with high quality factor Q is used: the erasure work is close to Landauer's bound, even at high speed. The drawback is the rise of the system's temperature T due to a weak coupling to the environment. Repeated erasures without letting the memory thermalize between operations result in continuous warming, potentially leading to a thermal noise overcoming the barrier between the potential wells. In such a case, the reset operation can fail to reach the targeted logical state. The reliability is characterized by the success rate after i successive operations. , T, and are studied experimentally as a function of the erasure speed. Above a velocity threshold, T soars while collapses: the reliability of too‐fast erasures is low. These experimental results are fully justified by two complementary models. It is demonstrated that Q ≃ 10 is optimal to contain energetic costs and maintain high‐reliability standards for repeated erasures at any speed.
Integration of multiomics data identifies candidate genes influencing pH levels in Beijing Black pigs
Authors: Tian Jingjing , Niu Naiqi , Wang Xiaoqing , Shi Liangyu , Yang Liyu , Li Mianyan , Shi Lijun , Liu Xin , Gao Hongmei , Hou Xinhua , Wang Ligang , Wang Lixian , Zhang Longchao , Zhao Fuping 
Published: October 2023

AbstractpH value is a crucial index used to evaluate pork quality due to its direct impact on specific meat characteristics. This study investigated the genetic mechanisms influencing pH values through measurements taken from the longissimus dorsi muscle of Beijing Black pigs at 2 h (pH2h) and 24 h (pH24h) postmortem. A total of 614 Beijing Black pigs were subsequently genotyped using the Illumina Porcine 50K SNP Chip. Heritability estimates for pH2h and pH24h were found to be 0.19 and 0.25, respectively, with a genetic correlation of 0.53. Furthermore, we conducted both a genome‐wide association study (GWAS) and an RNA sequencing (RNA‐seq) analysis, the latter of which identified differentially expressed genes (DEGs) between high and low pH groups. We identified 31, 6, and 32 single‐nucleotide polymorphisms in the pH2h, pH24h, and pH2–24h traits, respectively. The GWAS results revealed the presence of the SYT5 gene in both the pH2h and pH2–24h traits, while the SNX13 gene was simultaneously identified in the pH24h and pH2–24h traits. The RNA‐seq results also found SYT5 to be highly expressed, while SNX13 did not exhibit differential expression. Moreover, Gene Ontology and Kyoto Encyclopedia of Genes and Genomes analyses based on the DEGs revealed potential links between pH levels and the glycogen metabolic process as well as associations with the regulation of cell proliferation and calcium ion transmembrane transport. Ultimately, SYT5 and SNX13 emerged as key candidate genes affecting pH values at 2 and 24 h, respectively. These findings contribute to a better understanding of the genetic mechanisms affecting pork quality and safety and offer insights for enhancing meat quality through genetic improvement.
Impact of knowledge‐oriented leadership on innovative behavior, and employee satisfaction: The mediating role of knowledge‐centered culture for sustainable workplace
Authors: Alzghoul Amro , Khaddam Amineh A. , Alshaar Qasem , Irtaimeh Hani J. 
Published: October 2023

AbstractKnowledge‐oriented leadership phenomenon has captured the interest of scholars and industry leaders given its positive impact on sustainable organizational and employees outcomes. By drawing on affective event theory, this research explores the role of knowledge‐oriented leadership on knowledge‐centered culture, service innovative behavior and employees' job satisfaction and the mediating role of knowledge‐centered culture. The proposed model and hypotheses were tested using survey data gathered from 456 hotels and travel agencies employees in Jordan. The analysis was conducted using the contemporary structural equation modeling modus operandi, the partial least squares. The findings confirm that knowledge‐oriented leadership promotes knowledge‐centered culture in organizations, which in turn, promotes employees' job satisfaction and service innovative behavior. Knowledge‐centered culture concurrently mediates the path linking knowledge‐oriented leadership to job satisfaction and innovative behavior, respectively. The literature is devoid of scholarly work on the impact of knowledge‐oriented leadership and knowledge‐centered culture on employee outcomes in the tourism and hospitality industry context. This study being among the first to contribute to the literature from a developing country's perspective, prescribes empirical evidence, that knowledge‐oriented leadership promotes a knowledge‐centered culture in organizations, which subsequently leads to increased job satisfaction and service innovation. Furthermore, this study provides practical implications for organizations looking to promote a knowledge‐centered culture and enhance their employees' job satisfaction and service innovation.
Cardiac ventricular false tendons: A meta‐analysis
Authors: Carrasco Mark , Cabrito Tanya Maxinne Suntikul , Montalbano Michael J. , Hołda Mateusz K. , Walocha Jerzy , Tubbs R. Shane , Loukas Marios 
Published: October 2023

AbstractVentricular false tendons are fibromuscular structures that travel across the ventricular cavity. Left ventricular false tendons (LVFTs) have been examined through gross dissection and echocardiography. This study aimed to comprehensively evaluate the prevalence, morphology, and clinical importance of ventricular false tendons using a systematic review. In multiple studies, these structures have had a wide reported prevalence ranging from less than 1% to 100% of cases. This meta‐analysis found the overall pooled prevalence of LVFTs to be 30.2%. Subgroup analysis indicated the prevalence to be 55.1% in cadaveric studies and 24.5% in living patients predominantly studied by echocardiography. Morphologically, left and right ventricular false tendons have been classified into several types based on their location and attachments. Studies have demonstrated false tendons have important clinical implications involving innocent murmurs, premature ventricular contractions, early repolarization, and impairment of systolic and diastolic function. Despite these potential complications, there is evidence demonstrating that the presence of false tendons can lead to positive clinical outcomes.
Selinexor for the treatment of recurrent or metastatic salivary gland tumors: Results from the GEMS‐001 clinical trial
Authors: Hernando‐Calvo Alberto , Malone Eoghan , Day Daphne , Prawira Amy , Weinreb Ilan , Yang S. Y. Cindy , Wong Horace , Rodriguez Angela , Jennings Sarah , Eliason Anneli , Wang Lisa , Spreafico Anna , Siu Lillian L. , Hansen Aaron R. 
Published: October 2023

AbstractObjectivesWe aimed to evaluate the activity of selinexor, an oral selective inhibitor of nuclear export, in patients with recurrent or metastatic salivary gland tumors (SGT).MethodsGEMS‐001 is an open‐label Phase 2 study for patients with recurrent or metastatic SGT with two parts. In Part 1 of the protocol, patients had tumor samples profiled with targeted next generation sequencing as well as immunohistochemistry for androgen receptor, HER‐2 and ALK. For Part 2, patients with no targeted therapies available were eligible to receive selinexor 60 mg given twice weekly every 28 days. The primary endpoint was objective response rate. Secondary endpoints included progression‐free survival (PFS) and prevalence of druggable alterations across SGT.ResultsOne hundred patients were enrolled in GEMS‐001 and underwent genomic and immunohistochemistry profiling. A total of 21 patients who lacked available matched therapies were treated with selinexor. SGT subtypes (WHO classification) included adenoid cystic carcinoma (n = 10), salivary duct carcinoma (n = 3), acinic cell carcinoma (n = 2), myoepithelial carcinoma (n = 2), carcinoma ex pleomorphic adenoma (n = 2) and other (n = 2). Of 18 evaluable patients, stable disease (SD) was observed in 17 patients (94%) (SD ≥6 months in 7 patients (39%)). However, no objective responses were observed. The median PFS was 4.9 months (95% confidence interval, 3.4–10). The most common treatment‐related Grade 1–2 adverse events were nausea [17 patients (81%)], fatigue [16 patients (76%)], and dysgeusia [12 patients (57%)]. Most common treatment‐related Grade 3–4 adverse events were hyponatremia [3 patients (14%)], neutrophil count decrease [3 patients (14%)] and cataracts [2 patients (10%)]. No treatment‐related deaths were observed.ConclusionsAlthough tumor reduction was observed across participants, single agent selinexor anti‐tumor activity was limited.
Radiofrequency ablation combined with toripalimab for recurrent hepatocellular carcinoma: A prospective controlled trial
Authors: Wen Zhenyu , Wang Junxiao , Tu Bo , Liu Yane , Yang Yuqing , Hou Li , Yang Xiang , Liu Xiaoyan , Xie Hui 
Published: October 2023

AbstractObjectiveThe effectiveness and security of radiofrequency ablation (RFA) in combination with toripalimab (anti‐PD‐1) for the treatment of recurrent hepatocellular carcinoma (HCC) was studied in this article.MethodsTotal of 40 patients were enrolled in the study between September 2019 and November 2021. Data follow‐up ends in April 2022. The study’s main focus is on recurrence free survival (RFS), while the secondary objectives was safety. Chi‐square tests, Kaplan‐Meier, and Cox proportional hazards models were utilized to analyze the data.ResultsThe median follow‐up period was 21.40 months, and the median RFS was 15.40 months in the group that received combination therapy, which was statistically significantly different (HR: 0.44, p = 0.04) compared with the RFA group (8.2 months). RFS rates (RFSr) at 6, 12 and 18 months in the combination therapy groups and RFA groups were 80% vs 65%, 62.7% vs 35% and 48.7% vs 18.8%, respectively. Between the two groups, significant difference of RFSr was found at 18 months (p = 0.04). No statistical differences were observed between the two groups in terms of safeness (p > 0.05). The subgroup analysis indicated that the combination of RFA and anti‐PD‐1 led to better RFS than RFA alone. Moreover, patients benefited more from combination therapy in the groups younger than 60 years (HR: 0.26, p = 0.018), male (HR: 0.32, p = 0.028) and Child‐Pugh grade A (HR: 0.38, p = 0.032).ConclusionsCombining RFA with anti‐PD‐1 showed improved RFS and was deemed safe for patients with recurrent HCC who had previously undergone RFA treatment alone.
Study the Anticancer Properties of Thymol‐Loaded PEGylated Bovine Serum Albumin Nanoparticles Conjugated with Folic Acid
Authors: Al‐Salih Mohammed Yahya Awad , Pouresmaeil Vahid , Davoodi‐Dehaghani Fatemeh , Haghighi Hasti Nasiraei , Tabrizi Masoud Homayouni 
Published: October 2023

AbstractPhenolic compounds such as Thymol have an effective role in suppressing cancer, however, their low solubility in aqueous solution has limited their use. This study aimed to prepare Thymol (TY)‐loaded bovine serum albumin (BSA) nanoparticles surface‐modified with polyethylene glycol (PEG) conjugated with folic acid (FA) and evaluate their inhibitory activity on cancer cells. The TY‐BSA‐PEG‐FA was characterized using DLS, FESEM, and FTIR. The encapsulation efficiency (EE) was evaluated indirectly by using UV absorption. The antioxidant property of nanoparticles was evaluated by 2,2′‐azinobis(3‐ethylbenzothiazoline‐6‐sulfonic acid) (ABTS), 2,2‐diphenyl‐1‐picrylhydrazyl (DPPH), and ferric reducing ability of plasm (FRAP) methods. The effects of nanoparticles against cancer cells were investigated by MTT, AO/PI, flow cytometry, and real‐time qPCR methods. The results showed the spherical morphology of TY‐BSA‐PEG‐FA with an average size of 70.0 nm, a PDI of 0.32, a zeta potential of −11.3 mV, and an EE of 89.0±2.3 %. The cytotoxicity effects of nanoparticles against all cell lines were in a concentration‐dependent manner. AGS gastric cancer cells were reported to be the most vulnerable to treatment, while pancreatic cancer cells (PANC‐1) and normal skin cells (HFF) would be the most resistant. The SubG1 phase arrest of about 66 % occurred at 85 μg/mL. An increase in apoptotic cells in fluorescent staining, along with decreased expression of Bcl‐2 and increased expression of the BAX gene demonstrated the induction of apoptosis in treated cells. The powerful inhibitory effect of nanoparticles in inhibiting ABTS free radicals (IC50=82 μg/mL) and DPPH free radicals (IC50=844 μg/mL) and the ability to reduce iron ions indicated the antioxidant effects of TY‐BSA‐PEG‐FA. Based on these results, the synthesized nanoparticles may be suitable for further investigation in the treatment of cancer, notably gastric cancer.
Financing promise programs: Where the money comes from and where the money goes
Authors: Billings Meredith S. , Li Amy Y. , Gándara Denisa , Acevedo Rosa , Cervantes Diana , Turcios‐Villalta Jamie 
Published: October 2023

AbstractFree college/promise programs provide scholarships that cover students’ tuition and fees to attend college. These programs are flexible in that they can be adapted to local and/or state needs when crafting the design, scope, and benefits offered to students. Based on their adaptability, there is variation in the funding of these programs due to the available financial resources and programs’ ability to leverage established community and state partnerships. This chapter discusses how local and state promise programs are funded, what their funding covers, and how these programs affect postsecondary institutions’ finances. Also described are how promise programs have adapted to changing financial circumstances, especially during the COVID‐19 pandemic. Finally, the chapter provides recommendations for their financial sustainability.
More than just money? Early outcomes of Lake Tahoe Community College (LTCC) College Promise Program
Authors: Escobar Claudia , Friedmann Elizabeth , Tovar Silvia 
Published: October 2023

AbstractPromise programs have grown in popularity as a way to provide college tuition/fees and other student supports in the hopes of increasing college access and success. This chapter presents results from a comprehensive mixed‐methods evaluation of the Lake Tahoe Community College Promise Program. Using rich administrative data and interviews with students and alumni of the program, we find that promise students successfully completed two‐thirds of units attempted and persisted at higher rates in their first year compared to first‐time full‐time non‐promise students. We also find the program has high satisfaction levels among students and alumni who participated in interviews. This chapter provides additional insights into student outcomes, students’ experiences, and areas of refinement with the various components of the LTCC College Promise Program.
Metal‐Free Covalent Organic Frameworks for the Oxygen Reduction Reaction
Authors: Li Xuewen , Yang Shuai , Xu Qing 
Published: October 2023

AbstractThe oxygen reduction reaction (ORR) is the key reaction in metal air and fuel cells. Among the catalysts that promote ORR, carbon‐based metal‐free catalysts are getting more attention because of their maximum atom utilization, effective active sites and satisfactory catalytic activity and stability. However, the pyrolysis synthesis of these carbons resulted in disordered porosities and uncontrolled catalytic sites, which hindered us in realizing the catalysts’ design, the optimization of catalyst performance and the elucidation of structure–property relationship at the molecular level. Covalent organic frameworks (COFs) constructed with designable building blocks have been employed as metal‐free electrocatalysts for the ORR due to their controlled skeletons, tailored pores size and environments, as well as well‐defined location and kinds of catalytic sites. In this Concept article, the development of metal‐free COFs for the ORR is summarized, and different strategies including skeletons regulation, linkages engineering and edge‐sites modulation to improve the catalytic selectivity and activity are discussed. Furthermore, this Concept provides prospectives for designing and constructing powerful electrocatalysts based on the catalytic COFs.
Synthesis of Functional Isosorbide‐Based Polyesters and Polyamides by Passerini Three‐Component Polymerization
Authors: Sun Xiaofei , Wang Chengliang , Zhang Xu , Zhang Yan , Wang Qingfu , Sun Jingjiang 
Published: October 2023

AbstractEnvironmental issues are becoming more and more prominent, and bio‐based polymers are essential to alleviate environmental degradation by replacing traditional polymers. With this context, a new family of functional isosorbide‐based polyesters and polyamides with high glass transition temperature are prepared via Passerini‐Three component polymerization (P‐3CP). To optimize the P‐3CP conditions, the influence of the polymerization solvent, temperature, feed ratio on the molar mass of final polymers are investigated. The higher molar mass (up to 10100 g/mol) and yield (>70 %) are achieved under very mild conditions (30 °C, standard atmosphere). Functional side groups, such as alkenyl, alkynyl and methyl ester, were introduced into polymer structure via P‐3CP by using functional isocyanides. The obtained polyesters and polyamides are characterized by nuclear magnetic resonance (NMR) and infrared (IR) spectroscopies, differential scanning calorimetry (DSC) and thermal gravimetric analysis (TGA). All polymers are thermal stable and amorphous with variable glass transition temperatures (Tg). The obtained polyester has Tg up to 87.5 °C, while the Tg of polyamides (ISPA‐2) is detected to be 97.5 °C depending on the amide bonds in the polymer backbone and the benzene ring side groups. The cytotoxicity is investigated by the CCK‐8 assay against mBMSC cells to confirm the biological safety. Overall, this novel strategy provides an efficient approach to produce functional isosorbide‐based polyesters and polyamides, which are promising prospect for being applied to biodegradable materials.
Risk factor profile and outcomes of premature acute coronary syndrome after percutaneous coronary intervention: A 1‐year prospective design
Authors: Fallahzadeh Aida , Mehraban Saghar , Mahmoodi Tara , Sheikhy Ali , Naderian Mohammadreza , Afsaneh Aein Phd , Rafiee Hamed , Mehrani Mehdi , Tajdini Masih , Masoud‐kabir Farzad , Sadeghian Saeed , Hosseini Kaveh 
Published: October 2023

AbstractBackgroundThe prevalence of acute coronary syndrome (ACS) among young adults (premature ACS) has dramatically increased in recent years, especially in developing countries. Yet, the data on these patients' attributed risk factors and outcomes are inconsistent. In this study, we aimed to investigate these data in a cohort of premature ACS cases who underwent percutaneous coronary intervention (PCI) compared to older patients.HypothesisWe hypothesize that premature ACS patients undergoing PCI will exhibit different risk factor profiles and outcomes compared to non‐premature patients. specifically, we anticipate that premature patients do not necessarily have better outcomes than non‐premature.MethodsOverall, 3142 and 10 399 patients were included in premature and non‐premature groups, respectively. Patients' pre‐operative, post‐operative, and follow‐up data were retrieved retrospectively from the Tehran Heart Center PCI databank.ResultsThe mean age of premature and non‐premature cohorts was 48.39 and 67 years, respectively. Patients were predominantly male in both groups. Family history of coronary artery disease (CAD), dyslipidemia, smoking, and opium addiction were more prevalent among the younger cohort. After adjustment, in‐hospital mortality in younger patients was considerably higher, with all‐cause mortality and major cardiovascular and cerebrovascular events (MACCE) exhibiting no noticeable difference among the two groups.ConclusionsRisk factor profile is different in young patients, and traditional cardiovascular risk factors, such as hypertension and diabetes mellitus, are more prevalent among older adults. Younger age is not equivalent to a better prognosis; hence, similar or even more caution should be taken into consideration regarding secondary prevention for these patients.
The 17th EFMC Short Course on Medicinal Chemistry on Small Molecule Protein Degraders
Authors: Ciulli Alessio , O'Connor Suzanne , Chung Chun‐Wa , Hartung Ingo V. , Testa Andrea , Daniels Danette L. , Heitman Laura H. 
Published: October 2023

AbstractThe 17th EFMC Short Course on Medicinal Chemistry took place April 23–26, 2023 in Oegstgeest, near Leiden in the Netherlands. It covered for the first time the exciting topic of Targeted Protein Degradation (full title: Small Molecule Protein Degraders: A New Opportunity for Drug Design and Development). The course was oversubscribed, with 35 attendees and 6 instructors mainly from Europe but also from the US and South Africa, and representing both industry and academia. This report summarizes the successful event, key lectures given and topics discussed.
Effect of Paricalcitol Combined with Cinacalcet on Calcium and Phosphorus Metabolism in Patients Receiving Maintenance Hemodialysis
Authors: Zheng Feng‐yun , Tan Ya‐yin , Zhou Jia‐jun 
Published: October 2023

AbstractThis study was designed to compare the beneficial effects of paricalcitol combined with or without cinacalcet on calcium and phosphorus metabolism in patients undergoing maintenance hemodialysis (MHD). A total of 140 patients who received MHD in our hospital from March 2021 to March 2022 were randomly divided into a control group (intravenous paricalcitol, n = 70) and a test group (intravenous paricalcitol combined with oral cinacalcet, n = 70). Clinical baseline data and relevant laboratory parameters before treatment were compared. Additionally, calcium, phosphorus, intact parathyroid hormone in serum were measured and compared between the 2 groups before treatment and 1, 2, 3, 4, 5, 6, 9, 10, and 12 months after treatment. As a result, comparison before treatment demonstrated no significant difference in baseline data such as age, sex, and most laboratory parameters between the 2 groups (P > .05), but there was a significant difference in mean corpuscular volume (P < .001). The serum phosphorus level decreased and calcium level increased significantly in the 2 groups after treatment, while the intact parathyroid hormone level showed no significant change within 12 months of treatment (P > .05). In addition, the combined treatment for 6‐12 months caused a much lower phosphorus level (P < .05) and higher calcium level (P < .05) than the treatment with paricalcitol alone, and the difference increased with the extension of treatment time. Collectively, paricalcitol combined with cinacalcet, which is more effective than paricalcitol alone, has a positive effect on calcium and phosphorus metabolism in patients receiving MHD.