bluuebunny/crossref_metadata_2025_split huggingface dataset:
A RARE CLINICAL SYPHILIS ORAL MANIFESTATION DUE TO SEXUALLY TRANSMITTED DISEASE AMONG HOMOSEXUAL: CASE REPORT
Authors: T. Santo Agustin Ninintowe , Setiadhi Riani , Drakel Fika Faradillah 
Published: November 2023

Background: Syphilis is a sexually transmitted disease caused by Treponema pallidum, often found in Human Immunodeficiency Virus (HIV) patients and homosexuals. The oral manifestations are chancres, mucous patches, focal epithelial hyperplasia (FEH) and papilloma/condyloma. FEH is a rare oral mucosa disorder that occurs in immunocompromised patient. Objective: To present a rare oral manifestation in syphilis patient due to sexually transmitted infections. Case: A 25-year-old homosexual male came to Oral Medicine Department complaining of sores on the palate for 3 weeks and 2 weeks later a painless lump appeared. He was an HIV patient and had been taking ARVs since 6 months ago. Pain when opening the mouth, itching on his face and genital area. Intraoral revealed a soft, pedunculated, non-bleeding, mobile mass at the palate with a diameter about 2 cm, had the same color as the surrounding tissue. There was a reddish band-like area on the maxillary anterior gingival margin, suspected as Linear Gingival Erythema (LGE). Case management: 0.2% Chlorhexidine gluconate mouthwash was administered to prevent secondary infection and he was referred to Dermatovenereology and Periodontology Department. HBsAg Immunochromatography (negative), VDRL titer (reactive), TPHA titer (reactive) therefore diagnosis of syphilis was made and he was treated with a single dose Benzathine penicillin G 2.4 million units intramuscular. The oral lesions healed after 1 month therapy. Conclusion: FEH is a rare oral mucosa disorder in syphilis patients. Knowledge of the signs and symptoms of the disease is needed to make a diagnosis and a multidisciplinary approach to achieve successful treatment. Keywords: Oral manifestation, Sexual transmission, Syphilis, Treponemal infection
ANALYSIS OF SEVEN CASES OF ANGULAR CHEILITIS IN CHILDREN WITH BODY MASS INDEX AND BLOOD TEST RESULTS
Authors: Bakar Abu 
Published: November 2023

Background: Angular cheilitis is an acute or chronic inflammation at the angular of the lip which is characterized with fissures and the cracks. Objectives: The aim of this paper was to analyze seven cases of angular cheilitis in children with body mass index and blood test results. Case: There were seven children patients taken by their parents came to Baiturrahmah Academic Dental Hospital with a same complaint on a day. They complained about the injury and pain while open the mouth in the angular of the mouth. Intra oral examination showed the different clinical appearance at the angular of the mouth (white or red lesions and fissured or cracked). Body mass index analysis showed all the patients are underweight (9 -14) and mostly of the patients have a hemoglobin less than normal. Case Management: Pharmacological management was prescribed multivitamin supplements (vitamin B complex in syrup) and prescribed nystatin topically. One week after first visit, the anglar chelitis lesions has healed Conclusion: Low BMI might be the predisposing factor of the diseases. Keywords: Angular Cheilitis, Blood test, Body mass index
VITAMIN D DEFICIENCY AS A RISK FACTOR OF RECALCITRANT RECURRENT INTRAORAL HERPES (RIH)
Authors: Heldayani Iin , Hidayat Wahyu 
Published: November 2023

Background: Recurrent Intraoral Herpes (RIH) is secondary infection due to Herpes Simplex Virus (HSV) which is latent and most often involves lips and oral cavity. RIH infection could be reactivated as triggered by various factors, such as stress, immunosuppressant, hormonal, sunlight exposure or vitamin D deficiency. Objective: To describe vitamin D deficiency as a risk factor of recalcitrant RIH. Case: A 22-year-old woman came to Oral Medicine Clinic of RSUP. Dr. Hasan Sadikin Bandung with complaints of recurrent stomatitis for two years. Her stomatitis was recalcitrant and recurred several times a month. Intraoral examination revealed ulcers with yellowish-white base surrounded by haloerytem on the right of buccal and tongue lateral and oropharynx. Immunoserology laboratory examination showed an increasement of IgG HSV-1 value and vitamin D (25-OH) deficiency. Case Management: Patient was given Acyclovir 200mg 5 times daily for a week and Hyaluronic Acid 0.025% mouthwash as well as education to maintain an oral hygiene. Lesions were healed after 10 days therapy. However, 3 days later, lesion on the right buccal recurred with bigger size. Therapy was continued with additional administration of vitamin D and instructions to increase consumption of fruits, vegetables and to bask in the sun. Lesions of recalcitrant RIH were completely healed on the 5th visit or 45 days’ therapy. Conclusion: Vitamin D plays a role in all of the body's defense mechanisms and could be given to reduce the high recurrence rate of RIH as vitamin D has a protective effect against viral infections, particularly against HSV. Keywords: Deficiency Vitamin D, Herpes Infection, Recalcitrant, Recurrent Intraoral Herpes.
FAKTOR-FAKTOR YANG BERHUBUNGAN DENGAN STRES KERJA PADA PEKERJA FABRIKASI DI PT X TAHUN 2022
Authors: Hakiki Farhan , Ayu Ira Marti , Heryana Ade , Keumala Cut Alia , Utami Desyawati 
Published: November 2023

Ada banyak bahaya di tempat kerja yang berdampak ke kesehatan pekerja. Salah satu bahaya yang terabaikan yaitu gangguan psikis yang bisa memicu stress pekerja. Hasil survei pendahuluan menunjukkan sebesar 72,7% pekerja Fabrikasi di PT X mengalami stress berat dan sedang. Pekerjaan fabrikasi memiliki target pekerjaan yang tinggi namun dengan tenggat waktu yang sedikit dan tetap dituntun untuk menjaga kualitas pekerjaan. Penelitian ini bertujuan ini untuk mengetahui faktor-faktor yang berhubungan dengan stres kerja pada pekerja fabrikasi di PT X Tahun 2022. Desain penelitian yaitu cross-sectional dengan besar sampel 50 pekerja bagian fabrikasi PT X. Teknik pengambilan sampel dengan total sampling. Data penelitin akan dianalisis dengan analisis univariat dan bivariat dengan Uji Chi Square dan Fisher’s Exact. Hasil univariat menunjukkan proporsi tertinggi yaitu pekerja mengalami stress tinggi sebanyak 36 pekerja (72,0%), merasakan tuntutan tugas tinggi sebanyak 31 pekerja (62,0%), memiliki umur berisiko sebanyak 39 pekerja (78,0%), memiliki masa kerja baru sebanyak 38 pekerja (76,0%), dan sudah kawin sebanyak 44 pekerja (88,0%). Hasil bivariat menunjukkan terdapat hubungan antara tuntutan tugas (PR=1,84, CI 95% (1,12 – 3,01), dan umur (PR=3,10, CI 95% (1,17 – 8,22) terhadap stress kerja. Selain itu juga ditem,ukan tidak adanya hubungan antara masa kerja (PR=1,38 CI 95% (0,88 – 2,85) dan status perkawinan (PR=1,50 CI 95% (0,66 – 3,40) terhadap stress kerja. Perusahaan perlu memperhatikan tuntutan tugas yang diterima setiap pekerja, diharapkan tuntutan tugas yang diterima oleh pekerja tidak melebihi kapasitasnya.
PENGARUH BEBAN KERJA MENTAL TERHADAP STRESS KERJA PADA PEKERJA WANITA BAGIAN WEAVING
Authors: Dewi Anggreini Beta Citra , Rachmawati Siti , Wardani Aurina Firda Kusuma 
Published: November 2023

Translator Pendahuluan: PT Dan Liris merupakan perusahaan yang bergerak dalam industri textile terpadu. PT Dan Liris memiliki beberapa divisi, salah satunya adalah divisi penenunan (weaving). Operator weaving banyak mendapat tekanan yang tinggi dikarenakan barang yang dihasilkan harus sesuai dengan persyaratan klien. Berdasarkan gejala dan tanda fisiologis, perilaku, psikologis dan somatik, stres adalah hasil dari ketidaksesuaian antara seseorang dan lingkungannya, yang mengakibatkan ketidakmampuan mereka untuk menangani secara efektif berbagai tuntutan yang dibebankan pada mereka. Bekerja di bawah tekanan dengan batas waktu tertentu, bekerja dengan beban kerja berlebih, menjadi salah satu faktor yang memicu terjadinya stres akibat pekerjaan. Hal ini juga yang memicu stress kerja terutama pada pekerja wanita. Metode: Metode yang digunakan dalam penelitian ini adalah observasional analitik, dengan menggunakan pendekatan cross sectional. Pengambilan sample dilakukan dengan cara Purposive sampling. Instrumen yang digunakan dalam penelitian ini adalah lembar kuesioner NASA-Task Load Index (TLX) untuk menilai beban kerja mental, kuesioner Perceived Stress Scale (PSS-10) untuk menilai tingkat stres kerja. Analisis bivariat menggunakan uji korelasi spearman.Hasil: Berdasarkan hasil perhitungan beban kerja mental dan stress kerja yang didapatlkan bahwa tidak terdapat hubungan yang signifikan antara beban kerja mental dan stres kerja dengan nilai p-value= 0,052 dan r = 0,226. Koefisien korelasi bertanda positif yang berarti semakin tinggi beban kerja mental, maka akan diikuti tingginya stres kerja dan sebaliknya semakin rendah beban kerja mental, maka stres kerja juga akan semakin rendah.Kesimpulan: Hasil penelitian ini menunjukkan bahwa beban kerja mental tidak memiliki hubungan yang signifikan dengan stres kerja.Kata Kunci: Beban Kerja Mental; Stress Kerja
FOXO1 is a master regulator of CAR T memory programming
Authors: Mackall Crystal , Doan Alexander , Mueller Katherine , Chen Andy , Rouin Geoffrey , Daniel Bence , Lattin John , Chen Yingshi , Mozarsky Brett , Markovska Martina , Arias-Umana Jose , Hapke Robert Robert , Jung Inyoung , Xu Peng , Klysz Dorota , Bashti Malek , Quinn Patrick , Sandor Katalin , Zhang Wenxi , Hall Junior , Lareau Caleb , Grupp Stephan , Fraietta Joseph , Sotillo Elena , Satpathy Ansuman , Weber Evan 
Published: November 2023

Abstract
Poor CAR T persistence limits CAR T cell therapies for B cell malignancies and solid tumors1,2. The expression of memory-associated genes such as TCF7 (protein name TCF1) is linked to response and long-term persistence in patients3-7, thereby implicating memory programs in therapeutic efficacy. Here, we demonstrate that the pioneer transcription factor, FOXO1, is responsible for promoting memory programs and restraining exhaustion in human CAR T cells. Pharmacologic inhibition or gene editing of endogenous FOXO1 in human CAR T cells diminished the expression of memory-associated genes, promoted an exhaustion-like phenotype, and impaired antitumor activity in vitro and in vivo. FOXO1 overexpression induced a gene expression program consistent with T cell memory and increased chromatin accessibility at FOXO1 binding motifs. FOXO1-overexpressing cells retained function, memory potential, and metabolic fitness during settings of chronic stimulation and exhibited enhanced persistence and antitumor activity in vivo. Paradoxically, TCF1 overexpression failed to enforce canonical memory programs or enhance CAR T cell potency. Importantly, endogenous FOXO1 activity correlated with CAR T and TIL responses in patients, underscoring its clinical relevance in cancer immunotherapy. Our results demonstrate that memory reprogramming through FOXO1 can enhance the persistence and potency of human CAR T cells and highlights the utility of pioneer factors, which bind condensed chromatin and induce local epigenetic remodeling, for optimizing therapeutic T cell states.
Dynamic topology-mediated maturation of β-barrel proteins in BAM-catalyzed folding
Authors: Zhou Ruhong , Xie Teng , Chan Kevin , Pang Jie , Shen Chongrong , Chang Shenghai , Buratto Damiano , Tang Xiaodi , Zhang Xing , Dong Haohao 
Published: November 2023

Abstract
BamA is an essential component of the β-barrel assembly complex (BAM) that catalyzes the insertion and assembly of β-barrel outer membrane proteins (OMPs) in Gram-negative bacteria. BamA adopts two distinct conformations: the inward-open and outward-open β-barrels, regulated by periplasmic domains during different folding stages. However, it remains unclear how these conformational shifts promote the maturation of OMPs. Drawing from our prior work1, we identify a novel folding intermediate, characterized by an inward-open BamA and a non-closing OMP. This intermediate attains stability via enhanced hydrophobic interactions accompanying the topological alterations of the hybrid-barrel. The subsequent folding events of the hybrid-barrel are then sampled through molecular dynamics simulations augmented with enhanced sampling. Remarkably, our observations reveal that the spontaneous closure and separation are regulated by an induced-fit mechanism and supplementary hydrophobic interactions, prominently from the extracellular loop 1 (BL1) of BamA. Further cell viability assays confirm that disruption to BL1’s topology compromises BamA functionality and is detrimental to the bacteria. Taken together, our findings provide insights into the significance of BamA’s dynamic topological shifts during OMP maturation.
Gradient matters via filament diameter-adjustable 3D printing
Authors: Ruan Changshun , Qu Huawei , Gao Chongjian , Liu Kaizheng , Fu Hongya , Liu Zhiyuan , Kouwer Paul , Han Zhenyu 
Published: November 2023

Abstract
Gradient matters with hierarchical structures endow the natural world with excellent integrity and diversity, such as bone, bamboo, and wood. Currently, direct ink writing (DIW) three-dimensional (3D) printing is attracting tremendous interests, and has been used to explore the fabrication of one-dimensional (1D) and two-dimensional (2D) hierarchical structures by adjusting the diameter, spacing, and angle between filaments. However, it is difficult to generate complex 3D gradient matters owing to the inherent limitations of existing methods in terms of available gradient dimension, gradient resolution, and shape fidelity. Here, we report a filament diameter-adjustable 3D printing (FDA-3DP) strategy that enables conventional DIW 3D printers to produce 1D, 2D, and 3D gradient matters with tunable heterogeneous structures by continuously varying the volume of deposited ink on the printing trajectory. In detail, we developed diameter-programmable filaments by customizing the printing velocity and height. To achieve high shape fidelity, we specially added supporting layers with a constant minimum diameter at needed locations. Next, we showcased the multi-disciplinary applications of our approach in creating horizontal, radial and axial gradient structures, letter-embedded structures, metastructures, tissue-mimicking scaffolds, flexible electronics, and time-driven devices. By showing the enormous potential of this strategy, we anticipate that it could be easily extended to a variety of filament-based additive manufacturing technologies and facilitate the development of functionally graded structures.
Responses of streamflow to changes in climate and land use/cover in the typical semi-arid Liu River Basin, China
Authors: Li Mingqian , Wang He , Du Wei , Gu Hongbiao , Zhou Fanchao , Chi Baoming 
Published: November 2023

Abstract
Since the 1950s, China has implemented numerous soil and water conservation measures to control severe soil erosion in the Liu River Basin (LRB). While these measures have protected the upstream soil and water ecological environment, they have led to a sharp reduction in the downstream flow and the deterioration of the river ecological environment. Therefore, it is important to evaluate the impact of soil and water conservation measures on hydrological processes to assess long-term runoff changes. Using hydrological models and sensitivity analyses based on the Budyko hypothesis, this study quantitatively evaluated the effects of climate change, direct water withdrawal, and soil and water conservation measures on runoff in the LRB during different periods. The runoff series was divided into a baseline period (1956–1969) and two altered periods, period 1 (1970–1999) and period 2 (2000–2020). Human activities were the main cause of the decrease in runoff during the altered periods, contributing 86.3% (− 29.61 mm), while the contribution of climate change was only 13.7% (− 4.7 mm). The impact of climate change manifests as a decrease in flood volume caused by a reduction in precipitation during the flood season. Analysis of two flood cases indicated a 66–84% reduction in basin runoff capacity due to soil and water conservation measures in the upstream area. Soil and water conservation measures reduced the peak flow and total flood volume in the upstream runoff area by 77.98 and 55.16%, respectively, even with nearly double the precipitation. The runoff coefficient in the reservoir area without soil and water conservation measures was four times that in the conservation area. These results contribute to the re-evaluation of the soil and water conservation hydrological effects and provide important guidance for water resource planning and water conservation policy formulation in the LRB.
A Monte Carlo study of the Cellular Dosimetry for SNCT Comparison with MIRD S Values
Authors: Zhang Yi , Lan Changlin , Jiang Gong , Wang Jiahao , Yang Xianlin , Wei Yuting , Ge Yujie 
Published: November 2023

Abstract

Background
An interesting isotope, sulfur-33 (a stable isotope), has been proposed as an additional neutron capture or a cooperating target for enhancing boron neutron capture therapy. Recently, 33S was considered as the substitute for boron-10 in neutron capture radiotherapy. The 33S (n, α)30Si reaction emits the α particles useful for neutron capture therapy. Based on the Monte Carlo method, we investigated the dosimetric characteristics of the cellular model of several geometries for the sulfur-33 neutron capture therapy (SNCT).
Methods
Monte Carlo N-Particle (MCNP) was used for simulating the transport of α particles emitted by SNCT from the cellular model surface (CS), cytoplasm (Cy), or nucleus (N) of a single cell model. The model cells were defined as two concentric spheres consisting of the nucleus and cytoplasm. The radius of the cell model was Rc=6 µm Rn=3 µm. The S values (SC←C, SC←CS, SN←N, SN←Cy, SN←CS) were compared to the results with the Medical Internal Radiation Dosimetry (MIRD) method. Finally, S values of the cellular model of several geometries were calculated.
Results
The relative differences of MCNP versus MIRD method S values for SNCT ranged from 0.28% to 4.29% for C to C (SC←C), -2.82% to 0.05% for Cs to C (SC←Cs), 0.54% to 4.42% for N to N (SN←N), 0.72% to 3.14% for Cy to N (SN ←Cy), and -1.76% to 0.36% for CS to N (SN←CS). The ratios of SN←N/ SC←C, SN←CS/SC←C, SN←Cy/ SC←C decreased with increasing the cell and nucleus size.
Conclusion
The S value simulated by MCNP is in agreement with the MIRD method, which is proved to be reliable for the cellular dosimetry of SNCT by the Monte Carlo method. The Model Carlo method can be used instead of the MIRD method to accurately calculate cellular S values, which solves the problem of cell shape limitation in MIRD method (which is suitable for regular spherical cellular model).
Evaluation of Dental Plaque Area with Artificial Intelligence Model
Authors: Yüksel Büşra , Özveren Neslihan , Yeşil Çağrı 
Published: November 2023

Abstract

Objectives
This study aims to assess the diagnostic accuracy of an artificial intelligence (AI) system employing deep learning for identifying dental plaque, utilizing a dataset comprising photographs of permanent teeth.
Materials and Methods
In this study, photographs of 168 teeth belonging to 20 patients aged between 10–15 years, who met our criteria were included. Intraoral photographs were taken of the patients in two stages, before and after the application of the plaque staining agent. To train the AI system to identify plaque on teeth with dental plaque that is not discolored, plaque and teeth were marked on photos with exposed dental plaque. 140 teeth were used to construct the training group, while 28 teeth were used to create the test group. Another dentist reviewed images of teeth with dental plaque that wasn't discolored, and the effectiveness of AI in detecting plaque was evaluated using pertinent performance indicators. To compare the AI model and the dentist's evaluation outcomes, the mean IoU values were evaluated by the Wilcoxon test.
Results
The AI system showed higher performance in our study with a precision of 82% accuracy, 84% sensitivity, 83% F1 score, 87% accuracy, and 89% specificity in plaque detection. The AUC value was found to be 0.922, and the IoU value was 76%. Subsequently, the dentist's plaque diagnosis performance was also evaluated. The IoU value was 0.71, and the AUC was 0.833. The artificial intelligence model showed statistically significantly higher performance than the dentist. (p < 0.05)
Conclusions
The AI algorithm that we developed has achieved promising results and demonstrated clinically acceptable performance in detecting dental plaque compared to a dentist.
Effect of Bleaching Agents on Composite Resins With and Without BIS-GMA.
Authors: Melo María , Dumitrache Bianca , Ghilotti James , Sanz José Luís , Llena Carmen 
Published: November 2023

Abstract
Objective
to evaluate the change in color, hardness and roughness produced by carbamide peroxide (CP) at two different concentrations on two resins.
Materials and Methods
16% or 45% CP was applied to 66 resin discs with and without Bis-GMA. Color was measured with a spectrophotometer, and ΔEab and ΔE00 calculated. Microhardness tester and SEM were used.
Results
In both composites, the a* and b* coordinates tended to red and yellow, respectively, and were significant in the Bis-GMA group (p < 0.05). The ΔEab and ΔE00 were higher in the composite with Bis-GMA, regardless of the treatment received (p < 0.05). The microhardness was reduced in both composites regardless of the PC concentration compared to the control (p < 0.05). 45% CP reduced the microhardness in the resin group with Bis-GMA compared to 16% CP (p < 0.001), but was not significant in the resin without Bis-GMA (p = 1). An increase in roughness was directly proportional to the concentration of CP and it was more notable in the composite without Bis-GMA.
Conclusions
The composite with Bis-GMA showed a greater tendency to darken than the one without Bis-GMA. The surface hardness of the composite was reduced in both composites and was not influenced by CP concentration in the composite without Bis-GMA.
Clinical relevance:
Bleaching is a common procedure nowadays. It is important to know how how CP affects composites to establish a prognosis of the treatments, both in terms of color change, roughness or hardness.
Passing Path Predicts Shooting Outcome in Football
Authors: Cao Shun 
Published: November 2023

Abstract

What determines the outcome of a shot (scored or unscored) in football (soccer)? Numerous studies have investigated various aspects of this question, including the skills and physical/mental state of the shooter or goalkeeper, the positional information of shots, as well as the attacking styles and defensive formations of the opposing team. However, a critical question has received limited attention: How does the passing path affect the outcome of a shot? In other words, do different paths of the ball before shooting significantly influence the result of shots occurred in the same location? This study aims to fill the gap in the literature by conducting qualitative studies using a dataset comprising 34,938 shots, along with passing paths from top-tier football leagues and international competitions such as the World Cup. Eighteen path features were extracted and applied to three different machine-learning models. The results indicate that the passing path, whether with or without the positional information of shots, can indeed predict shooting outcomes and reveal influential path features. Moreover, it suggests that taking quick actions to move the ball across areas with a high probability of scoring a goal can significantly increases the chance of a successful shot. Interestingly, certain path features that are commonly considered important for team performance, such as the distribution of passe among players and the overall path length, were found to be less significant for shooting outcomes. These findings enhance our understanding of the effective ball-passing and provide valuable insights into the critical factors for achieving successful shots in football games.