bluuebunny/crossref_metadata_2025_split huggingface dataset:
Optimized two-stage time-truncated control chart for Weibull distribution
Authors: Ali Shafaqat , Jorge Jose , Aslam Muhammad , Kashif Muhammad 
Published: January 2024

AbstractIn this article, an attribute control chart is proposed when the lifetime of a product follows a Weibull distribution in two-stage sampling, which is based on the number of failures from a truncated life test. The coefficients of the proposed double sampling attribute control chart and the test duration are determined so that the average run length when the process is in control is close to the target value. An overview is reported on how double sampling np control charts work. Tables reporting the out-of-control average run lengths are given for various shift parameters. A case study is given to illustrate the proposed control chart for industrial use. A comparison of two-stage and single-stage sampling of failure of products is discussed.
Decarbonising road freight transport: The role of zero-emission trucks and intangible costs
Authors: Aryanpur Vahid , Rogan Fionn 
Published: January 2024

AbstractThe road freight sector faces significant challenges in decarbonisation, driven by high energy demand and limited availability of low-emission fuels and commercialised zero-emission vehicles. This study investigates intangible costs associated with advanced electric and hydrogen-powered trucks, including recharging/refuelling time, cargo capacity limitations, and buyer reluctance towards emerging technologies. Utilising a comprehensive whole-systems modelling approach considering low- and zero-emission fuels, inter-sectoral dynamics, and the carbon budget, we explore cost-optimal decarbonisation pathways for heavy, medium, and light trucks. Scenario and sensitivity analyses reveal the following insights: (1) Electric trucks dominate the market under mitigation pathways across all weight categories. However, the inclusion of intangible costs triggers a shift, leading to the emergence of hydrogen fuel cell vehicles for heavy trucks, while battery electric vehicles are preferred for medium and small trucks. (2) Prioritising heavy truck decarbonisation and taking early action are crucial to avoid carbon lock-in effects. (3) Considering limited decarbonisation options, where electric and hydrogen-fuelled trucks are pivotal, this research highlights the significance of policy instruments targeting operational expenditures over conventional purchase price incentives. Such policies offer dual benefits by supporting truck owners and directing incentives more precisely towards achieving measurable emission reductions.
The phosphorylated pathway of serine biosynthesis affects sperm, embryo, and sporophyte development, and metabolism in Marchantia polymorpha
Authors: Wang Mengyao , Tabeta Hiromitsu , Ohtaka Kinuka , Kuwahara Ayuko , Nishihama Ryuichi , Ishikawa Toshiki , Toyooka Kiminori , Sato Mayuko , Wakazaki Mayumi , Akashi Hiromichi , Tsugawa Hiroshi , Shoji Tsubasa , Okazaki Yozo , Yoshida Keisuke , Sato Ryoichi , Ferjani Ali , Kohchi Takayuki , Hirai Masami Yokota 
Published: January 2024

AbstractSerine metabolism is involved in various biological processes. Here we investigate primary functions of the phosphorylated pathway of serine biosynthesis in a non-vascular plant Marchantia polymorpha by analyzing knockout mutants of MpPGDH encoding 3-phosphoglycerate dehydrogenase in this pathway. Growth phenotypes indicate that serine from the phosphorylated pathway in the dark is crucial for thallus growth. Sperm development requires serine from the phosphorylated pathway, while egg formation does not. Functional MpPGDH in the maternal genome is necessary for embryo and sporophyte development. Under high CO2 where the glycolate pathway of serine biosynthesis is inhibited, suppressed thallus growth of the mutants is not fully recovered by exogenously-supplemented serine, suggesting the importance of serine homeostasis involving the phosphorylated and glycolate pathways. Metabolomic phenotypes indicate that the phosphorylated pathway mainly influences the tricarboxylic acid cycle, the amino acid and nucleotide metabolism, and lipid metabolism. These results indicate the importance of the phosphorylated pathway of serine biosynthesis in the dark, in the development of sperm, embryo, and sporophyte, and metabolism in M. polymorpha.
Type 2 diabetes and its genetic susceptibility are associated with increased severity and mortality of COVID-19 in UK Biobank
Authors: Lee Aeyeon , Seo Jieun , Park Seunghwan , Cho Youngkwang , Kim Gaeun , Li Jun , Liang Liming , Park Taesung , Chung Wonil 
Published: January 2024

AbstractType 2 diabetes (T2D) is known as one of the important risk factors for the severity and mortality of COVID-19. Here, we evaluate the impact of T2D and its genetic susceptibility on the severity and mortality of COVID-19, using 459,119 individuals in UK Biobank. Utilizing the polygenic risk scores (PRS) for T2D, we identified a significant association between T2D or T2D PRS, and COVID-19 severity. We further discovered the efficacy of vaccination and the pivotal role of T2D-related genetics in the pathogenesis of severe COVID-19. Moreover, we found that individuals with T2D or those in the high T2D PRS group had a significantly increased mortality rate. We also observed that the mortality rate for SARS-CoV-2-infected patients was approximately 2 to 7 times higher than for those not infected, depending on the time of infection. These findings emphasize the potential of T2D PRS in estimating the severity and mortality of COVID-19.
Mobilization of cholesterol induces the transition from quiescence to growth in Caenorhabditis elegans through steroid hormone and mTOR signaling
Authors: Schmeisser Kathrin , Kaptan Damla , Raghuraman Bharath Kumar , Shevchenko Andrej , Rodenfels Jonathan , Penkov Sider , Kurzchalia Teymuras V. 
Published: January 2024

AbstractRecovery from the quiescent developmental stage called dauer is an essential process in C. elegans and provides an excellent model to understand how metabolic transitions contribute to developmental plasticity. Here we show that cholesterol bound to the small secreted proteins SCL-12 or SCL-13 is sequestered in the gut lumen during the dauer state. Upon recovery from dauer, bound cholesterol undergoes endocytosis into lysosomes of intestinal cells, where SCL-12 and SCL-13 are degraded and cholesterol is released. Free cholesterol activates mTORC1 and is used for the production of dafachronic acids. This leads to promotion of protein synthesis and growth, and a metabolic switch at the transcriptional level. Thus, mobilization of sequestered cholesterol stores is the key event for transition from quiescence to growth, and cholesterol is the major signaling molecule in this process.
Parbendazole as a promising drug for inducing differentiation of acute myeloid leukemia cells with various subtypes
Authors: Matsuo Hidemasa , Inagami Aina , Ito Yuri , Ito Nana , Iyoda Shinju , Harata Yutarou , Higashitani Moe , Shoji Kota , Tanaka Miu , Noura Mina , Mikami Takashi , Kato Itaru , Takita Junko , Nakahata Tatsutoshi , Adachi Souichi 
Published: January 2024

AbstractAcute myeloid leukemia (AML) is a malignancy characterized by differentiation arrest of hematopoietic precursor cells. Differentiation therapy is effective for patients with acute promyelocytic leukemia; however, only a few effective differentiation therapies have been established for patients with other AML subtypes. In this study, seven benzimidazole anthelmintics were examined to determine the effects of differentiation on AML cells. The expression of monocyte markers (CD11b and CD14) was elevated after treatment with most benzimidazole anthelmintics. Among these drugs, parbendazole (PBZ) induced AML cell differentiation at low concentration. PBZ induced the monocyte marker expression, KLF4/DPYSL2A gene expression, and apoptosis for 21 AML cell lines with various subtypes and a primary AML sample. Finally, an in vivo analysis using an AML patient-derived xenograft mouse model showed a significant decrease in the chimerism level and prolonged survival in PBZ-treated mice. These findings could lead to a more effective differentiation therapy for AML.
The efficacy of chemotherapy is limited by intratumoral senescent cells expressing PD-L2
Authors: Chaib Selim , López-Domínguez José Alberto , Lalinde-Gutiérrez Marta , Prats Neus , Marin Ines , Boix Olga , García-Garijo Andrea , Meyer Kathleen , Muñoz María Isabel , Aguilera Mònica , Mateo Lidia , Stephan-Otto Attolini Camille , Llanos Susana , Pérez-Ramos Sandra , Escorihuela Marta , Al-Shahrour Fatima , Cash Timothy P. , Tchkonia Tamara , Kirkland James L. , Abad María , Gros Alena , Arribas Joaquín , Serrano Manuel 
Published: January 2024

AbstractChemotherapy often generates intratumoral senescent cancer cells that strongly modify the tumor microenvironment, favoring immunosuppression and tumor growth. We discovered, through an unbiased proteomics screen, that the immune checkpoint inhibitor programmed cell death 1 ligand 2 (PD-L2) is highly upregulated upon induction of senescence in different types of cancer cells. PD-L2 is not required for cells to undergo senescence, but it is critical for senescent cells to evade the immune system and persist intratumorally. Indeed, after chemotherapy, PD-L2-deficient senescent cancer cells are rapidly eliminated and tumors do not produce the senescence-associated chemokines CXCL1 and CXCL2. Accordingly, PD-L2-deficient pancreatic tumors fail to recruit myeloid-derived suppressor cells and undergo regression driven by CD8 T cells after chemotherapy. Finally, antibody-mediated blockade of PD-L2 strongly synergizes with chemotherapy causing remission of mammary tumors in mice. The combination of chemotherapy with anti-PD-L2 provides a therapeutic strategy that exploits vulnerabilities arising from therapy-induced senescence.
Prophylactic and long-lasting efficacy of senolytic CAR T cells against age-related metabolic dysfunction
Authors: Amor Corina , Fernández-Maestre Inés , Chowdhury Saria , Ho Yu-Jui , Nadella Sandeep , Graham Courtenay , Carrasco Sebastian E. , Nnuji-John Emmanuella , Feucht Judith , Hinterleitner Clemens , Barthet Valentin J. A. , Boyer Jacob A. , Mezzadra Riccardo , Wereski Matthew G. , Tuveson David A. , Levine Ross L. , Jones Lee W. , Sadelain Michel , Lowe Scott W. 
Published: January 2024

AbstractSenescent cells, which accumulate in organisms over time, contribute to age-related tissue decline. Genetic ablation of senescent cells can ameliorate various age-related pathologies, including metabolic dysfunction and decreased physical fitness. While small-molecule drugs that eliminate senescent cells (‘senolytics’) partially replicate these phenotypes, they require continuous administration. We have developed a senolytic therapy based on chimeric antigen receptor (CAR) T cells targeting the senescence-associated protein urokinase plasminogen activator receptor (uPAR), and we previously showed these can safely eliminate senescent cells in young animals. We now show that uPAR-positive senescent cells accumulate during aging and that they can be safely targeted with senolytic CAR T cells. Treatment with anti-uPAR CAR T cells improves exercise capacity in physiological aging, and it ameliorates metabolic dysfunction (for example, improving glucose tolerance) in aged mice and in mice on a high-fat diet. Importantly, a single administration of these senolytic CAR T cells is sufficient to achieve long-term therapeutic and preventive effects.
Expression of transglutaminase-2 (TGM2) in the prognosis of female invasive breast cancer
Authors: Blows Fiona M. , Ali H. Raza , Cope Wei , Pharoah Paul D. P. , Pike Claire V. S. , Provenzano Elena , Coussons Peter 
Published: January 2024

Abstract
Background
Transglutaminase 2 (TGM2) is a protein expressed in several isoforms in both intra- and extra-cellular tissue compartments. It has multiple functions that are important in cancer biology and several small studies have suggested expression of TGM2 in breast cancers is associated with a poorer prognosis. The aim of this study was to evaluate the role of intra-cellular and extra-cellular TGM2 expression in breast cancer and to determine whether there were any differences by hormone receptor status.

Methods
We carried out TGM2 immunostaining of tissue micro-arrays comprising 2169 tumour cores and scored these for both intra- and extra-cellular and expression.

Results
Intra-cellular (tumour cell) TGM2 positivity was associated with a better prognosis (HR = 0.74, 95% CI 0.59–0.92) with a larger effect stronger in hormone-receptor-negative cases (HR = 0.56, 95% CI 0.37–0.85). Extra-cellular (stromal) TGM2 expression was associated with a poorer prognosis (HR = 1.47, 95% CI 1.06–2.03) with a stronger association in hormone-receptor-positive cases (HR = 1.60, 95% CI 1.09–2.34).

Conclusion
Tissue compartment and hormone receptor status differences in the effect of TGM2 expression on clinical outcomes of breast cancer may reflect the different functions of TGM2.
Knowledge and Perspectives of Developmental Language Disorders: The Pilot Development of a Survey of Professionals Working in Law Enforcement
Authors: Benes Clare , Lund Emily 
Published: January 2024

Purpose:
The purpose of this study was to pilot test a survey of professionals within the justice system about their knowledge and perceptions of developmental language disorders (DLDs) and to gather initial data supporting their knowledge and perceptions.

Method:
One hundred thirty-six adults in Texas with law enforcement jobs, primarily police officers, participated in this study. Participants completed a survey consisting of 78 questions about their background, experiences with DLD, and beliefs about communication. Additionally, 42 adults who did not work in law enforcement completed the survey twice to establish the initial measures of survey reliability.

Results:
This survey demonstrated sufficient test–retest reliability with adults not in law enforcement, and results indicated the emergence of two subscales within the survey. Law enforcement professionals appeared to have limited knowledge of DLD, and many linked language-related behaviors with credibility. A majority did agree with giving accommodations to individuals who struggle with language and reported interest in receiving training to recognize and accommodate DLD.

Conclusions:
This pilot study demonstrates a need for collaboration between speech-language pathologists and law enforcement professionals and provides data for a survey that could be used across professional groups in the justice system to measure knowledge and perspectives of DLDs. This work represents an initial step in an iterative process of survey development for law enforcement professionals.

Supplemental Material:

https://doi.org/10.23641/asha.25033718
Folding at home: Artificial intelligence and crypto symbiosis for the science
Authors: Tuma Ivan , Lansiaux Edouard 
Published: January 2024

AbstractFolding at Home community gathers pecuniary crypto interest to an altruist cause (medical drugs research participation). There are many possibilities of ‘teams’ for folding, some of which allow compensation in cryptomonies. The authors will therefore study the three major communities in order to compare them, in a cost‐benefit study logic. A cost‐benefit analysis was performed between CURECOIN, BANANO, DOGECOIN folding, DOGECOIN mining and their communities on social platforms based on several outcomes: ‘Points Per Day (PPD)’, ‘Whattomine Mh/s Equivalent’, ‘Graphics Processing Units (GPU) Thermal Design Power/Typical Board Power Watts’, ‘Coins per 1,000,000 PPD’, ‘Coins per Day’, ‘Cost Per Coin’, ‘Cost Per Day’, ‘kWh Used Per Day’. Actually, BANANO, thanks to a large community and bots, has the highest PPD production and the lowest energetic cost on Central Processing Unit per week. On GPUs, DOGECOIN folding has the lowest weekly cost. However, the DOGECOIN community cannot produce as many PPD as the Banano team. CURECOIN offers a good compromise between the environmental point of view and the profitability one. To ensure fairness, the choice of the crypto and the way to earn it that has to be solved should be a pure public good, that is, perfectly non‐rival in consumption and non‐excludable. Indeed, the primary goal of those three communities is to allow scientific progress (thanks to Folding at Home) before allowing a return on investment.
YOLOv7‐RepFPN: Improving real‐time performance of laparoscopic tool detection on embedded systems
Authors: Liu Yuzhang , Hayashi Yuichiro , Oda Masahiro , Kitasaka Takayuki , Mori Kensaku 
Published: January 2024

AbstractThis study focuses on enhancing the inference speed of laparoscopic tool detection on embedded devices. Laparoscopy, a minimally invasive surgery technique, markedly reduces patient recovery times and postoperative complications. Real‐time laparoscopic tool detection helps assisting laparoscopy by providing information for surgical navigation, and its implementation on embedded devices is gaining interest due to the portability, network independence and scalability of the devices. However, embedded devices often face computation resource limitations, potentially hindering inference speed. To mitigate this concern, the work introduces a two‐fold modification to the YOLOv7 model: the feature channels and integrate RepBlock is halved, yielding the YOLOv7‐RepFPN model. This configuration leads to a significant reduction in computational complexity. Additionally, the focal EIoU (efficient intersection of union) loss function is employed for bounding box regression. Experimental results on an embedded device demonstrate that for frame‐by‐frame laparoscopic tool detection, the proposed YOLOv7‐RepFPN achieved an mAP of 88.2% (with IoU set to 0.5) on a custom dataset based on EndoVis17, and an inference speed of 62.9 FPS. Contrasting with the original YOLOv7, which garnered an 89.3% mAP and 41.8 FPS under identical conditions, the methodology enhances the speed by 21.1 FPS while maintaining detection accuracy. This emphasizes the effectiveness of the work.
Evaluation of Porcine Collagen Membranes Used with Guided Bone Regeneration for Critical Defects: A Histological, Histomorphometric, Immunohistochemical, and Inflammatory Profile Analysis
Authors: Ramos Edith Umasi , Leandro Miguel Nino Chávez , Criales Jesús Omar Cárdenas , Buitron Marisol Rossana Ortega , Verástegui Edgar Simón , Carbajal Wilbert Manzanedo , Adrianzén Ronald Christian Solís , Grijalva Anibal Eleuterio Espinoza , Baylon Antonio Alberto Ballarte , Bassi Ana Paula Farnezi 
Published: January 2024

Abstract
Objective The objective of this study was to compare the effectiveness of two porcine collagen membranes of different origin used for guided bone regeneration procedures.
Materials and Methods Resorbable collagen membrane from porcine dermis (Bio-Gide, Geistlich Pharma AG, Wolhusen, Switzerland) and resorbable collagen membrane from porcine pericardium (Jason, Institut Straumann AG, Peter Merian-Weg, Switzerland) were evaluated; histological, histometric, immunohistochemical, and inflammatory profile analyses were performed. The study was carried out on critical defects created in the calvaria of 72 rats (Rattus norvegicus albinus, Wistar variety) divided into three groups: coagulum group (Co), porcine pericardium group (JS), and porcine collagen group (BG). The defects were filled with clot, over which the membranes were placed. The animals were euthanized 7, 15, 30, and 60 days after surgery.
Statistical Analysis The Shapiro–Wilk test was used to assess data distribution. Analysis of variance (ANOVA) and the Bonferroni multiple comparison test were used to compare the differences across the mean values of the variables. Nonparametric tests, Mann–Whitney and Wilcoxon W, were used for the quantitative analysis of the inflammatory profile. A significance level of 5% (p < 0.05) was adopted with a confidence interval of 95%. SPSS software version 2.0 was used.
Results A total of 1,008 analyses were performed on 288 histological slides. It was noted that both types of collagen membranes used in this study were effective for the guided bone regeneration procedure, with a greater proportion and thickness of bone formation among recipients of the BG (735 points, p = 0.021). This membrane also had greater permeability (62.25). The animals in the JS group, which received the porcine pericardial membrane, showed early and accelerated bone formation from early bone tissue, milder osteopontin and osteocalcin levels, and greater inflammatory reaction (86.4).
Conclusion The collagen membrane from porcine dermis demonstrated a more orderly and physiological repair process, while the porcine pericardial membrane presented a more accelerated repair process that did not remain constant over time.
Free Communications of the Seventh Annual Al Ain Research Day, Al Ain, United Arab Emirates, June 9, 2023
Authors: Nair Satish C. , Al-Neyadi Asma M. , Al-Mazrouei Raya A.M. , Jamil Gohar A.M. , Al-Qawasmeh Khaled H.A. , Al-Kuwaiti Abdulla H. , Al-Baghdadi Omaema O. , Alawadhi Aydah M.S. , Al-Alanqar Abdulrahman , Alkendi Fatima R. , Chabban Ahmed , Al Dahmani Khaled Mohammed 
Published: January 2024

AbstractThese are the free communications of the Seventh Annual Al Ain Research Day, Al Ain, United Arab Emirates, on June 9, 2023. Oral and poster communications are listed separately. The abstracts came from various medical specialties, including internal medicine, endocrinology, cardiology, nursing, neurology, nephrology, obstetrics and gynecology, oncology, and general medicine.
Intralesional Triamcinolone Diacetate In the Treatment of Keloids and Hypertrophic Scars—Use of the Dermo-Jet
Authors: Theogaraj Sam D. , Mani Mani M. 
Published: January 2024

Summary1. The history of steroids in the treatment of keloid is reviewed.2. The Dermo-Jet has been described and the advantages in its use, in the treatment of these lesions, is stressed.3. An analysis of 70 lesions treated with Triamcinolone has revealed that 80% bave obtained relief of symptoms and 759%, regression.4. The recurrence rate has been found to be somewhere in between those quoted for the Caucasian and Negro patients.
Manifestation and Management of Cancrum Oris
Authors: Mani Mani M. , Theogaraj Sam D. 
Published: January 2024

SummaryFifty cases of cancrum oris seen during the past nine years are presented. Exan-thematous fevers—measles, chicken-pox and small-pox occur as the predisposing illness in 48%, of this series.The disease is of acute onset and the gangrene demarcates rapidly.The pattern of tissue necrosis is in the shape of a cone.
Plastic Surgery In Kangra (A leaf from the history of Plastic Surgery in India)
Authors: Almast S. C. 
Published: January 2024

SummaryPlastic surgical operations for cut and deformed noses and torn ears had been practised at Kangra for over 500 years by a family of nose-surgeons locally called Kanghairas. Hakim Dina Nath is the last surviving descendant of the faimily who himself performed these operations till 1937. This paper is a report of the “on the spot” inquiry conducted by the author to verify the facts for himself.
Transposition of Penis and Scrotum: Review and a Case Report
Authors: Sinha R. N. , Reddy Anji K. 
Published: January 2024

SummaryOne case of retroposition of the penis and scrotum associated with penile hypopspadias and partially bifid scrotum is presented (Fig. 2—4). The literature regarding the previous reported cases and the surgical correction is reviewed, along with an account of the embryology of the external genitalia.
New Approach to Ventral Hernia Repair
Authors: Rai S. , Saronwala K. C. , Mittal S. N. 
Published: January 2024

Summary35 cases of ventral hernias of varying sizes have been presented. The hernial sac was opened and excised inall. The repair was done by invaginating layers of monofilament nylon thread. This technique has shown gratifying results. There had been no incidence of recurrence of hernia nor of operative mortality and it seems to be applicable even to large ventral hernias.