bluuebunny/crossref_metadata_2025_split huggingface dataset:
The effectiveness of STOP-X training program on knee valgus angle and balance in female basketball players with dynamic knee valgus
Authors: Rostami Mohadeseh , Sedaghati Parisa , Daneshmandi Hassan 
Published: December 2023

Abstract

Introduction: Dynamic knee valgus (DKV) along with poor balance is the cause of anterior cruciate ligament (ACL) injury in athletes, and identification and correction of these factors are always of interest to researchers. Therefore, the purpose of this research was to investigate the effect of the STOP-X program on knee valgus angle, static and dynamic balance in female basketball players with DKV defect.Materials and methods: The present study was a quasi-experimental. The samples of this research included 30 female basketball players with DKV defect who were purposefully selected from the statistical population of female basketball players and were randomly assigned to two control (n=15) and experimental (n=15) groups. Dynamic knee valgus status was evaluated with the single-leg landing (SLL) test, static balance with the BASS STICK test, and dynamic balance with the Y-balance test (YBT). As a warm-up program, the experimental group performed the STOP-X program for 25-40 minutes for eight weeks (three times per week), and the control group did their traditional warm-up program. Data analysis was done by statistical analysis of ANCOVA and Paired-Samples T Test with SPSS version 26.Results: The results showed that with the use of the STOP-X program, there was a significant difference between the experimental and control groups in the variables of knee valgus angle (η2=0.72, P=0.001), static balance (η2=0.47, P=0.001), and total dynamic balance score (η2 = 0.74, P = 0.001). So that the experimental group performed better performance compared to the control group.Conclusion: It seems that applying STOP-X preventive warm-up exercises can improve static and dynamic balance in female basketball players with DKV defects, in addition to reducing the knee valgus angle. Therefore, it can be recommended to sports trainers to benefit from the advantages by substituting STOP-X preventive exercises instead of traditional warm-up.
Identification of Tropane Alkaloid Chemotypes and Genotypes in Hyoscyamus niger L.
Authors: Kramer Lawrence , Jayanty Sastry , Reckhow David A. , Sathuvalli Vidyasagar 
Published: December 2023

Tropane alkaloids (TA) are compounds widespread in the Solanaceae family. The genera Atropa, Brugmansia, Hyoscyamus, and Scopolia, produce the pharmaceuticals hyoscyamine (Hy) and scopolamine (Sc), which are valued for their antimuscarinic and anticholinergic actions. The enzyme hyoscyamine 6β-hydroxylase (H6H) (EC 1.14.11.11) catalyzes both the hydroxylation of hyoscyamine to 6β-hydroxyhyoscyamine and the epoxidation of the latter, leading to scopolamine (Hashimoto et al. 1993). During the examination of three genes in the TA biosynthetic pathway, the first committed step, the path branch point, and the final step in 13 accessions of Hyoscyamus niger from North America and Europe, genetic variations were found to be absent except in the h6h gene locus (GenBank: D26583.1). Quantification of TA showed average concentrations of 26 to 520 μg/g of dry leaf tissue among the accessions. From a monohybrid cross of the expected (Pennsylvania accession Ames 3103, aa) and novel (Netherlands accession PI 641691, bb) genotypes, the F2 population (n = 104) leaf and root tissues were extracted, analyzed for Hy and Sc contents, and compared with the h6h genotypes (aa, ab, bb). The polymorphism showed Mendelian inheritance. The presence of the polymorphic gene bb showed a marginally significantly greater concentration of hyoscyamine in the leaf tissue (P = 0.0675) and significantly greater concentration in root tissue (P = 0.0436), along with increased concentration of scopolamine in the root tissue (P = 0.0494) compared with the aa genotype. The increase in overall TA in the root tissue of the genotype bb was accompanied by a reduction in scopolamine in the foliar tissue. The 694-bp b amplicon has been sequenced for comparison with the expected 550-bp a amplicon and can be a useful enzymatic variant for TA metabolic engineering.
Traditional cereal-based dishes of the Newari community of Nepal and their preparation process
Authors: Magar Rukmani Pache , Shrestha Grishma , Kandel Kamana , Lamichhane Bijaya , Thapa Bidhya Laxmi , Thagunna Bishal 
Published: December 2023

Around the world, cereal grains provide a significant source of dietary nutrients. Since prehistoric times, cereal-based food products have formed the foundation of the human diet. Fermented foods made from cereals account for a significant portion of the calorie intake in developing nations. Worldwide dietary recommendations are urging the consumption of whole grains due to mounting evidence that these grains and food products made from them can improve health in ways other than just giving energy and minerals. The creation of novel food items with qualities that improve health will be aided by the understanding gained from the functional qualities of the many chemical components found in whole grains.
Therefore, the main aim of this study is to illuminate the varied application of cereals like rice, maize, wheat, and barley in preparing a wide range of delightful dishes like (Aila, Dhindo, Yomari, Selroti, Chatamari, Khurma, Chiura, and Lakhamari) which holds immense significance in shaping the cultural identity of the Newari community. In this study, the nutritional advantages of cereals highlight their crucial role in maintaining the health and well-being of the Newar community. Cereals are abundant in essential vitamins, fibers, minerals, and carbohydrates as a fundamental component of a well-balanced diet that promotes overall well-being
Assessment of the quality of cream-white candy with the addition of fruit and berry paste during storage
Authors: Shydakova-Kameniuka Olena , Zagorulko Aleksey , Kasabova Kateryna , Zahorulko Andrii 
Published: December 2023

One of the trends in modern nutrition is targeting people who care about their health. Confectionery made from sugar is in stable demand among people of different age groups, and research into their enrichment with vital nutrients is promising. One of the ways to implement such a task is the use of fruit and berry processing products, in particular in the form of pastes, during the production of candies. The purpose of the research was to evaluate the quality of cream-whipped candies with the addition of apple, quince and blackcurrant paste (40: 50: 10) during storage.
It was established that the process of hydrolysis of the lipid component of candies with paste occurs at a higher rate compared to the control. This is due to their higher acidity and moisture. However, the fats of candies with the addition of fruit and berry paste are less prone to the formation of peroxides, which is explained by the presence in their composition of a significant number of polyphenolic compounds with pronounced antioxidant properties (anthocyanins and catechins), which are absent in the control sample. In particular, on the 60th day of storage, the value of the peroxide value for the sample with the additive was 27.9 % less than that of the control product.
It has been established that candies with paste lose moisture more slowly due to the higher content of non-starch polysaccharides. Thus, on the 60th day, the moisture content of the control decreased by 11.33 %, and the product with paste decreased by 8.72 %. Smaller moisture losses ensure greater stability of their rheological characteristics during storage. It was noted that the strength and density of such candies increase more slowly than in the sample without the additive.
The results of the research indicate the compliance of cream-whipped candies with fruit and berry paste to the normative storage terms in terms of oxidative stability of the lipid complex, physico-chemical and sensory indicators
Experimental and numerical investigation of Engineered Injection and Extraction (EIE) induced with three-dimensional flow field
Authors: Asha Farsana M. , Sajikumar N. , Subaida E. A. 
Published: December 2023

Abstract
In situ groundwater remediation technique is a commonly adopted method for the treatment of contaminated groundwater and the porous media associated with it. Engineered Injection and Extraction (EIE) has evolved as an improved methodology for in situ remediation, where sequential injection and extraction of clean water around the treatment area enhances the spreading of treatment reagents by inducing additional flow fields. Conventional EIE studies were based on flow fields in two dimensions. There are only limited experimental and theoretical studies exploring the potential of inducing a three-dimensional flow field using EIE. The present study experimentally and numerically evaluates the effect of a three-dimensional flow field induced by partially screened wells. EIE experiments were conducted on a laboratory-scale aquifer model with laterite soil as the porous medium. Tracer transport in porous medium was studied by measuring the concentration at various observation points and enhanced dilution was observed when EIE was employed with partially screened wells. Experimental observations were also used to calibrate and validate the numerical model developed using Visual MODFLOW Flex. Enhancement in spreading was quantified in terms of concentration mass attenuation and maximum mass attenuation was observed when EIE was employed with partially screened wells.
Magnetic nanomaterials as an effective absorbent material for removal of fluoride concentration in water: a review
Authors: Panhwar Sallahuddin , Keerio Hareef Ahmed , Khokhar Nadar Hussain , Muqeet Muhammad , Ali Zouhaib , Bilal Muhammad , Ul Rehman Ajeeb 
Published: December 2023

Abstract

The rapid increases in industrialization and populations are significant sources of water contamination. The speed with which contamination of groundwater and surface water occurs is becoming a serious problem and poses a significant obstacle for water stakeholders. Heavy metals, organic, and inorganic contaminants in the form of suspended and dissolved materials are just a few of the contaminants that can be found in drinking water. One of the most common contaminants in the water is fluoride, which is responsible for numerous toxic diseases. Different traditional techniques, for example, coagulation, ion exchange, absorption, and membrane filtration are being used to dispose of fluoride from water. However, nanomaterials such as magnetic nanoparticles (NPs) are very efficient, reliable, cost-effective, and stable materials to replace traditional water treatment techniques. There has been an increase in interest in the application of nanomaterials to the purification of drinking water over the past few decades. The use of magnetic NPs, such as metal and metal oxide NPs, to remove fluoride ions and organic matter from water is highlighted in this review article. Also, this section also discusses the properties, benefits and drawbacks, and difficulties of utilizing magnetic NPs in the process of purifying drinking water.
Exposure assessment of nitrate and phenol derivatives in Tehran's water distribution system
Authors: Hadi Mahdi , Bashardoust Parnia , Solaimany Aminabad Mehri , Nazmara Shahrokh , Rezvani Ghalhari Mohammad , Mesdaghinia Alireza , Hemmati Borji Saeedeh 
Published: December 2023

Abstract

The presence of organic and inorganic contaminants in drinking water is a global concern. Nitrate and phenol derivatives are examples of pollutants that could be of anthropogenic origin. They are associated with numerous health risks, underscoring the importance of monitoring their presence in drinking water. This study aimed to measure nitrate and phenol derivatives, including 2,4-Dichlorophenol (2,4-DCP), Pentachlorophenol (PCP), 2,4,5-Trichlorophenol (2,4,5-TCP), 2-Chlorophenol (2-CP), 4-Chlorophenol (4-CP), and phenol, in Tehran's water distribution system (WDS). The pollutants in Tehran's WDS were significantly and positively correlated with precipitation. The Hazard Quotient (HQ) and the Excess Lifetime Cancer Risk (ELCR) of the detected pollutants were estimated. The results showed that the regional mean of nitrate and PCP in Tehran's WDS were 35.58±8.71mg L−1 and 76.14±16.93 ng L−1 lower than the guideline values of 50 mg L−1 and 1000 ng L−1, respectively. Some districts exhibited nitrate concentration exceeding the allowable limit by a factor of 1.2 to 2.3. Consequently, the nitrate intake in some districts constituted approximately 50% of the reference dose. While PCP as a phenol derivative with more health concerns was identified in Tehran's WDS, the likelihood of its health effects was determined to be negligible.
Land use and land cover change impact on characteristics of surface evapotranspiration in semi-arid environment of Western Rajasthan, India
Authors: Saxena Dhruv , Choudhary Mahender , Sharma Gunwant 
Published: December 2023

Abstract

The development of the Indira Gandhi Nahar Pariyojana (IGNP) in western Rajasthan has significantly impacted land use and land cover (LULC) changes, which have hugely transformed the hydrologic cycle in recent decades. Hence, we investigate the surface evapotranspiration (ET) response to LULC changes in the IGNP for the period from 1990 to 2020. The Surface Energy Balance algorithm (Surface Energy Balance Algorithm for Land) was applied to the Landsat dataset along with local weather data obtained from the Indian Meteorological Department. A machine learning-based random forest classifier was applied to develop the LULC maps. The higher values of ET are mainly distributed in the northwest. Area covered by croplands has shown an increasing trend over the decades at a rate of 734.76 km2·a−1, urban settlements/ built-up areas increased at a rate of 14.67 km2·a−1, barren area decreased gradually at a rate of 751.67 km2·a−1, and area covered by the few water bodies showed minor fluctuations. Overall, the LULC changes have a smaller influence on ET rates but has a considerable impact on the total ET in the IGNP region due to an increase in the area covered by vegetation as a result of increased water availability.
Promises and Pitfalls of Calcineurin Inhibitors in COVID-19: A
Systematic Review and Meta-analysis of Controlled Trials
Authors: Heydari Behrooz , Sahebnasagh Adeleh , Omrani Mohammad Ali , Azimi Saeed , Dehghani Mohammad Hossein , Salehi-Abargouei Amin , Farman Farnoosh , Saghafi Fatemeh 
Published: December 2023

Objective:
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2)
causes a violent attack on the body that leads to multi-organ failure and death in
COVID-19 patients. The aim of this study was to systematically review the existing literature
on the potential benefits of calcineurin inhibitors (CIs) as anti-vascular endothelial
growth factor (VEGF) agents in improving the clinical outcomes of COVID-19 patients.

Methods:
We searched various databases, including PubMed, Scopus, ISI Web of Science,
Google Scholar, Cochrane databases, and ClinicalTrials.gov from 31st December,
2019, to 3rd February, 2023, for relevant controlled trials. The quality of the evidence
was assessed using the Cochrane Collaboration tool. Comprehensive Meta-Analysis
Software was used for the statistical analyses using a random-effects model.

Results:
Three trials enrolling 293 participants were reviewed in the present systematic
review and meta-analysis. The results showed CIs to lead to a significant reduction in
mortality rate [risk ratio (RR): 0.598, 95% CI: 0.404-0.885, P-value = 0.010] with a low
between-study heterogeneity (Cochrane Q test: I2 = 0.000%, P-value = 0.371). Pooled
analysis of two studies (84 patients) illustrated that CIs could not significantly increase
the rate of hospital discharge (RR: 1.161, 95% CI: 0.764-1.764, P-value = 0.485) and
heterogeneity was not significant (Cochrane Q test: I2 = 26.798%, P-value = 0.242).

Conclusion:
CIs are able to inhibit the virus nucleocapsid protein so that they can prevent
replication and respiratory tract tissue damage caused by SARS-CoV-2. Based on
the characteristics mentioned in detail, CIs can play a potential therapeutic role for
COVID-19 patients.
Antitumor Effects of Curcumin on Cervical Cancer with the Focus on
Molecular Mechanisms: An Exegesis
Authors: Govahi Ali , Zahmatkesh Neda , Pourbagherian Omid , Khas Neda Maleki , Salamzadeh Tala , Mehr Hasti Moshtagh , Babaei Esmaeil , Hajivalili Mahsa 
Published: December 2023

Abstract:
Cervical cancer is one of the most prevalent malignancies among females and is correlated with a
significant fatality rate. Chemotherapy is the most common treatment for cervical cancer; however, it has a
low success rate due to significant side effects and the incidence of chemo-resistance. Curcumin, a polyphenolic
natural compound derived from turmeric, acts as an antioxidant by diffusing across cell membranes into the
endoplasmic reticulum, mitochondria, and nucleus, where it performs its effects. As a result, it's been promoted
as a chemo-preventive, anti-metastatic, and anti-angiogenic agent. As a consequence, the main goal of the
present review was to gather research information that looked at the link between curcumin and its derivatives
against cervical cancer.
Italian Guidelines for the Management of Sporadic Primary Hyperparathyroidism
Authors: Vescini Fabio , Borretta Giorgio , Chiodini Iacopo , Boniardi Marco , Carotti Marina , Castellano Elena , Cipriani Cristiana , Eller-Vainicher Cristina , Giannini Sandro , Iacobone Maurizio , Salcuni Antonio Stefano , Saponaro Federica , Spiezia Stefano , Versari Annibale , Zavatta Guido , Mitrova Zuzana , Saulle Rosella , Vecchi Simona , Antonini Debora , Basile Michele , Giovanazzi Alexia , Paoletta Agostino , Papini Enrico , Persichetti Agnese , Samperi Irene , Scoppola Alessandro , Novizio Roberto , Calò Pietro Giorgio , Cetani Filomena , Cianferotti Luisella , Corbetta Sabrina , De Rimini Maria Luisa , Falchetti Alberto , Iannetti Giovanni , Laureti Stefano , Lombardi Celestino Pio , Madeo Bruno , Marcocci Claudio , Mazzaferro Sandro , Miele Vittorio , Minisola Salvatore , Palermo Andrea , Pepe Jessica , Scillitani Alfredo , Tonzar Laura , Grimaldi Franco , Cozzi Renato , Attanasio Roberto 
Published: December 2023

Aim::
This guideline (GL) is aimed at providing a clinical practice reference for the
management of sporadic primary hyperparathyroidism (PHPT) in adults. PHPT management in
pregnancy was not considered.

Methods::
This GL has been developed following the methods described in the Manual of the
Italian National Guideline System. For each question, the panel appointed by Associazione
Medici Endocrinology (AME) and Società Italiana dell’Osteoporosi, del Metabolismo Minerale
e delle Malattie dello Scheletro (SIOMMMS) identified potentially relevant outcomes, which
were then rated for their impact on therapeutic choices. Only outcomes classified as “critical”
and “important” were considered in the systematic review of evidence. Those classified as “critical”
were considered for the clinical practice recommendations.

Results::
The present GL provides recommendations about the roles of pharmacological and
surgical treatment for the clinical management of sporadic PHPT. Parathyroidectomy is recommended
in comparison to surveillance or pharmacologic treatment in any adult (outside of pregnancy)
or elderly subject diagnosed with sporadic PHPT who is symptomatic or meets any of
the following criteria:
• Serum calcium levels >1 mg/dL above the upper limit of normal range.
• Urinary calcium levels >4 mg/kg/day.
• Osteoporosis disclosed by DXA examination and/or any fragility fracture.
• Renal function impairment (eGFR <60 mL/min).
• Clinic or silent nephrolithiasis.
• Age ≤50 years.
Monitoring and treatment of any comorbidity or complication of PHPT at bone, kidney, or
cardiovascular level are suggested for patients who do not meet the criteria for surgery or are
not operated on for any reason. Sixteen indications for good clinical practice are provided in
addition to the recommendations.

Conclusion::
The present GL is directed to endocrinologists and surgeons - working in hospitals,
territorial services or private practice - and to general practitioners and patients. The recommendations
should also consider the patient’s preferences and the available resources and expertise.
Evaluating the Effectiveness of School Closure in COVID-19–Related Syndromes From Community-Based Syndromic Surveillance: Longitudinal Observational Study
Authors: Chung Ping-Chen , Chen Kevin J , Chang Hui-Mei , Chan Ta-Chien 
Published: December 2023

Background
During the COVID-19 pandemic, a school closure policy was adopted to prevent cluster transmission in schools and subsequent household transmission. However, the effectiveness of school closure is not consistent in studies conducted in different countries.

Objective
This study aimed to explore the association between school closure and the daily standardized incidence of COVID-19–related syndromes in an outpatient syndromic surveillance system.

Methods
We calculated the incidence of COVID-19–related syndromes derived from a community-based syndromic surveillance system between the first week of January and the second or fourth weeks after school closure in 2021 and 2022 in Taipei City, Taiwan. The effect of school closure on the standardized incidence of COVID-19–related syndromes was evaluated by interrupted time series analysis using an autoregressive integrated moving average with a distributed lag function. The exogenous variables were changes in human mobility measured by Google COVID-19 community mobility reports. Furthermore, the models quantified the influence of different age groups and the hierarchy of medical facilities, such as clinics or community hospitals.

Results
School closure was only negatively and significantly associated with the overall standardized incidence of COVID-19–related syndromes in 2021 for 2 weeks after the intervention (coefficient −1.24, 95% CI −2.40 to −0.08). However, in different age groups, school closure had a significantly negative association with the standardized incidence among people aged 13-18 years and ≥65 years for 2 weeks after the intervention in clinics in 2021. In community hospitals, school closure was significantly positively associated with the standardized incidence among people aged 19-24 years in 2021. In 2022, 2 weeks after the intervention, school closure had a significantly negative association with the standardized incidence among people aged 0-6, 7-12, and 19-24 years in community hospitals and aged >45 years in clinics. Furthermore, the standardized incidence was positively associated with movement change toward grocery and pharmacy stores in all age groups in 2022. In addition, movement changes toward residences were significantly positively associated with the standardized incidence among all age groups.

Conclusions
Overall, school closure effectively suppresses COVID-19–related syndromes in students owing to the reduction of physical contact. In addition, school closure has a spillover effect on elderly people who stay at home.