bluuebunny/crossref_metadata_2025_split huggingface dataset:
Impact of process and outcome quality on intention for continued use of voice assistants
Authors: Saavedra Álvaro , Chocarro Raquel , Cortiñas Mónica , Rubio Natalia 
Published: December 2023

Purpose
This paper aims to understand how the perceived usefulness of voice assistants (VAs) is affected by the perceived quality of the process (interaction) and the outcome (information). The authors also aim to determine the extent to which the perceived usefulness of VAs improves the perceived privacy associated with their use and increases users’ intention to continue using them. Consumer technology innovativeness is included as a personal trait moderator, to compare the results between tech and nontech innovators. For this purpose, the authors use the framework of the uses and gratifications theory (U&GT).

Design/methodology/approach
A survey of 467 VA users was conducted and structural equation modeling was used to analyze the data.

Findings
The authors identify two main determinants of the perceived usefulness of VAs that influence users’ intention to continue using this technology, process quality and outcome quality. These two factors influence the continued use of VAs in different ways depending on the technology innovativeness of the consumers. The results show that tech innovators are oriented toward the interactive experience, and therefore, mainly value the process quality. In addition, nontech innovators are oriented toward a satisfactory response from VAs, and therefore, primarily value the outcome quality. In addition, the positive effect of perceived usefulness on perceived privacy is higher for tech innovators.

Originality/value
This study enhances the literature on the perceived usefulness of VAs within the framework of U&GT. It identifies two antecedents (process quality and outcome quality) of perceived usefulness and observes significant differences based on technological innovativeness.
Transcriptome‐derived molecular resources for the conservation of threatened butterflies in Korea
Authors: Patnaik Hongray Howrelia , Park Jie Eun , Sang Min Kyu , Song Dae Kwon , Jeong Jun Yang , Hong Chan Eui , Kim Yong Tae , Shin Hyeon Jun , Ziwei Liu , Hwang Hee Ju , Park So Young , Kang Se Won , Ko Jung Ho , Jeong Heon Cheon , Park Hong Seog , Jo Yong Hun , Han Yeon Soo , Patnaik Bharat Bhusan , Lee Yong Seok 
Published: December 2023

AbstractButterflies are expedient biodiversity indicators of a healthy environment. As virtuous pollinators, they provide environmental and economic benefits to the agricultural and natural ecosystem. The global loss of the butterfly community, especially in tropical regions, is causing irreparable damage to the ecological landscape. This decline in population is due to habitat degradation, forest succession, loss of symbiotic relations, economic loss due to flooding, forest development plans, low grassland area, global warming, and reforestation. Moreover, the limited information on the molecular resources of butterflies impedes informed conservation planning. The Threatened Species Initiative (TSI) of Korea has started to utilize the benefits of transcriptome‐guided discovery of molecular resources of a few butterfly species, and a few others are in the pipeline. The cataloging of new genes and genetic markers provides the possibility to promote selective utilization of fitness traits for adaptation of the species to the wild and a newer habitat. In this review, we assessed the versatility of whole‐transcriptome information of the Korean threatened butterfly species, such as the lycaenid Protantigius superans and Spindasis takanosis, the Nymphalid butterfly, Fabriciana nerippe, and the Papilionid species Parnassius bremeri. The schema employed under TSI, including the sequencing and downstream bioinformatics pipeline, could act as a reference for research outside of Korean butterflies. While the molecular resources are available to be exploited, their utilization for conservation is still in its infancy. It is important to synthesize these studies together to catalyze further conservation work applying genomics approaches.
Health‐care resource use among patients who use illicit opioids in England, 2010–20: A descriptive matched cohort study
Authors: van Hest Naomi , Brothers Thomas D. , Williamson Andrea , Lewer Dan 
Published: December 2023

AbstractBackground and aimsPeople who use illicit opioids have higher mortality and morbidity than the general population. Limited quantitative research has investigated how this population engages with health‐care, particularly regarding planned and primary care. We aimed to measure health‐care use among patients with a history of illicit opioid use in England across five settings: general practice (GP), hospital outpatient care, emergency departments, emergency hospital admissions and elective hospital admissions.DesignThis was a matched cohort study using Clinical Practice Research Datalink and Hospital Episode Statistics.SettingPrimary and secondary care practices in England took part in the study.ParticipantsA total of 57 421 patients with a history of illicit opioid use were identified by GPs between 2010 and 2020, and 172 263 patients with no recorded history of illicit opioid use matched by age, sex and practice.MeasurementsWe estimated the rate (events per unit of time) of attendance and used quasi‐Poisson regression (unadjusted and adjusted) to estimate rate ratios between groups. We also compared rates of planned and unplanned hospital admissions for diagnoses and calculated excess admissions and rate ratios between groups.FindingsA history of using illicit opioids was associated with higher rates of health‐care use in all settings. Rate ratios for those with a history of using illicit opioids relative to those without were 2.38 [95% confidence interval (CI) = 2.36–2.41] for GP; 1.99 (95% CI = 1.94–2.03) for hospital outpatient visits; 2.80 (95% CI = 2.73–2.87) for emergency department visits; 4.98 (95% CI = 4.82–5.14) for emergency hospital admissions; and 1.76 (95% CI = 1.60–1.94) for elective hospital admissions. For emergency hospital admissions, diagnoses with the most excess admissions were drug‐related and respiratory conditions, and those with the highest rate ratios were personality and behaviour (25.5, 95% CI = 23.5–27.6), drug‐related (21.2, 95% CI = 20.1–21.6) and chronic obstructive pulmonary disease (19.4, 95% CI = 18.7–20.2).ConclusionsPatients who use illicit opioids in England appear to access health services more often than people of the same age and sex who do not use illicit opioids among a wide range of health‐care settings. The difference is especially large for emergency care, which probably reflects both episodic illness and decompensation of long‐term conditions.
Cross‐talk between gastric cancer and hepatic stellate cells promotes invadopodia formation during liver metastasis
Authors: Ren Chuanfu , Yang Zhi , Xu En , Kang Xing , Wang Xingzhou , Sun Qi , Wang Chao , Zhang Liang , Miao Ji , Luo Banxin , Chen Kai , Liu Song , Shen Xiaofei , Lu Xiaofeng , Yin Kai , Wang Meng , Xia Xuefeng , Guan Wenxian 
Published: December 2023

AbstractIn gastric cancer (GC), the liver is a common organ for distant metastasis, and patients with gastric cancer with liver metastasis (GCLM) generally have poor prognosis. The mechanism of GCLM is unclear. Invadopodia are special membrane protrusions formed by tumor cells that can degrade the basement membrane and ECM. Herein, we investigated the role of invadopodia in GCLM. We found that the levels of invadopodia‐associated proteins were significantly higher in liver metastasis than in the primary tumors of patients with GCLM. Furthermore, GC cells could activate hepatic stellate cells (HSCs) within the tumor microenvironment of liver metastases through the secretion of platelet‐derived growth factor subunit B (PDGFB). Activated HSCs secreted hepatocyte growth factor (HGF), which activated the MET proto‐oncogene, MET receptor of GC cells, thereby promoting invadopodia formation through the PI3K/AKT pathway and subsequently enhancing the invasion and metastasis of GC cells. Therefore, cross‐talk between GC cells and HSCs by PDGFB/platelet derived growth factor receptor beta (PDGFRβ) and the HGF/MET axis might represent potential therapeutic targets to treat GCLM.
miR‐17‐92 cluster‐BTG2 axis regulates B‐cell receptor signaling in mantle cell lymphoma
Authors: Kawaji‐Kanayama Yuka , Tsukamoto Taku , Nakano Masakazu , Tokuda Yuichi , Nagata Hiroaki , Mizuhara Kentaro , Katsuragawa‐Taminishi Yoko , Isa Reiko , Fujino Takahiro , Matsumura‐Kimoto Yayoi , Mizutani Shinsuke , Shimura Yuji , Taniwaki Masafumi , Tashiro Kei , Kuroda Junya 
Published: December 2023

AbstractB‐cell receptor (BCR) signaling is critically activated and stable for mantle cell lymphoma (MCL), but the underlying mechanism of the activated BCR signaling pathway is not clear. The pathogenic basis of miR‐17‐92 cluster remains unclear although the oncogenic microRNA (miRNA) miR‐17‐92 cluster is highly expressed in patients with MCL. We revealed that miR‐17‐92 cluster overexpression is partly dependent on SOX11 expression and chromatin acetylation of MIR17HG enhancer regions. Moreover, miR‐17‐92 cluster regulates not only cell proliferation but BCR signaling activation in MCL cell lines. To comprehensively identify miR‐17‐92 cluster target genes, we performed pulldown‐seq, where target RNA of miRNA was captured using the biotinylated miRNA mimics and magnetic bead‐coated streptavidin, and quantified using next‐generation sequencing. The pulldown‐seq identified novel miRNA target genes, including tumor suppressors such as BTG2 (miR‐19b), CDKN2A (miR‐17), SYNE1 (miR‐20a), TET2 (miR‐18, miR‐19b, and miR‐92a), TNFRSF10A (miR‐92a), and TRAF3 (miR‐17). Notably, the gene expression profile data of patients with MCL revealed that BTG2 expression was negatively associated with that of BCR signature genes, and low BTG2 expression was associated with poor overall survival. Moreover, BTG2 silencing in MCL cell lines significantly induced BCR signaling overactivation and cell proliferation. Our results suggest an oncogenic role of miR‐17‐92 cluster‐activating BCR signaling throughout BTG2 deregulation in MCL. Furthermore, this may contribute to the prediction of the therapeutic efficacy and improved outcomes of MCL.
Juvenile probation staff perceptions of engaging families in substance use services
Authors: Piper Kaitlin N. , Pankow Jennifer , Wood Jennifer D. 
Published: December 2023

AbstractObjectivesStudy objectives were to (a) understand juvenile justice staff members' experiences with engaging families in youth substance use services and (b) identify staff‐perceived barriers to family engagement across steps of substance use service provision.BackgroundLack of family involvement in juvenile justice system substance use (SU) services is a key barrier to successful treatment of justice‐involved youth.MethodFrom June through November 2015, 33 focus groups were conducted at juvenile justice system probation sites across seven states. There were 263 participants, which included juvenile justice probation and behavioral health staff.ResultsStrategies to engage families in services were highly variable across the 33 juvenile justice sites. Juvenile justice staff members identified barriers to family engagement in SU services including family discomfort, distrust of juvenile justice staff, lack of family service compliance, difficulties accessing SU services, lack of transportation, insurance and cost barriers, low perceived need for treatment, lack of SU education, and SU treatment stigma.Conclusion and ImplicationsBarriers to family engagement directly impact the success of SU service provision in juvenile justice settings. Implementation of strategies to engage families of justice‐involved youth (e.g., providing tangible, informational, and emotional support to families, and involving families in juvenile justice policy and care decisions) are critical to improving SU outcomes among this vulnerable population.
Health literacy, worry about unmet needs for medical care, and psychological well‐being among older Chinese adults
Authors: Li Jia , Wang Qi , Zhou Xiaochen 
Published: December 2023

AimThis study aims to examine the relationship between older adults' health literacy and their psychological well‐being and the role of worry about future unmet needs for medical care in mediating this relationship.MethodsWe adopted a sample of 965 older Chinese people aged 60+ (49.74% female) from the 2021 Chinese General Social Survey. A series of structural equation models (SEMs) were performed. Health literacy was measured by three items regarding older people's ability to understand medical professionals, ask them questions, and read medical instructions. A single‐item question was adopted to measure participants' worry about unmet needs for future medical care. Psychological well‐being was measured by three items regarding emotional problems and depressed or anxious mood in the past 4 weeks.ResultsWorry about future unmet needs for medical care mediates the relationship between lack of health literacy and Chinese older people's psychological well‐being. The indirect effect accounts for 22.3% of the total effect. The SEM model has a satisfactory model fit (goodness of fit index = 1.000, comparative fit index = 0.999, Tucker‐Lewis index = 0.997, root mean square error of approximation = 0.009, standardized root mean square residual = 0.023, chi‐square test = 50.96,  P = 0.321).ConclusionsThe findings of this study underscore the importance of improving communication quality between healthcare providers and older adults. Clinical interventions that promote health literacy and address worries about unmet needs for medical services may benefit older adults. Geriatr Gerontol Int 2024; 24: 202–207.
Prevalence of apical periodontitis and non‐retention of root‐filled teeth in hypertensive patients: Systematic review and meta‐analysis
Authors: Cabanillas‐Balsera Daniel , Areal‐Quecuty Victoria , Cantiga‐Silva Cristiane , Cardoso Carolina de Barros Morais , Cintra Luciano Tavares Angelo , Martín‐González Jenifer , Segura‐Egea Juan J. 
Published: December 2023

AbstractBackgroundSeveral studies have suggested a relationship between AP, as well as the loss of root‐filled teeth (RFT), and hypertension (HTN).ObjectivesThe aims of this systematic review and meta‐analysis were to investigate the prevalence of AP, and non‐retention of RFT, in hypertensive patients.MethodsA search was performed in PubMed/MEDLINE, Web of Science, Scopus and EMBASE. The inclusion criteria established were studies published until February 2023, comparing hypertensive subjects with controls, assessing the prevalence of AP and/or providing data on the prevalence of non‐retained RFT. Meta‐analysis was performed using the RevMan (analyst) tool to determine the pooled prevalence of AP and loss of RFT. Risk of bias was assessed using the Cochrane Risk‐of‐Bias tool. The quality of evidence was assessed by GRADE.ResultsThe search strategy identified 454 articles, and only eight met the inclusion criteria. Six studies had analysed the association between AP and HTN and two studies had analysed the association between non‐retention of RFT and HTN. Meta‐analysis showed and overall OR = 1.71 (95% CI = 0.92–3.16; p = .09) for the prevalence of AP among patients with HTN. The prevalence of non‐retention of RFT among patients with HTN has an overall OR = 1.78 (95% CI = 1.60–1.98; p = .000001). The risk of bias in the individual studies was low or moderate, and the quality of the overall evidence has shown a level of certainty very low.DiscussionThere is no association between the prevalence of AP and HTN. In addition, hypertensive patients have significantly increased odds of losing RFT. Given the high prevalence of hypertension, it is very common to perform root canal treatments on hypertensive patients. It is imperative to communicate this heightened risk to patients and recommend periodic monitoring of oral health and hypertension, paying special attention to this subset of patients.RegistrationPROSPERO CRD42022302385.
Promoting wound recovery through stable intestinal flora: Reducing post‐operative complications in colorectal cancer surgery patients
Authors: Chen Qiao , Wang Zhi , Wu Bai Xiang 
Published: December 2023

AbstractIn recent years, the relationship between intestinal flora and post‐operative recovery, particularly in colorectal cancer (CRC) surgery patients, it has been hypothesized that intestinal flora stability influences wound healing, reduces complications and improves overall recovery outcomes after surgical interventions. This study examined the relationship between intestinal flora stability and post‐operative recovery in patients undergoing CRC surgery. Between May 2020 and 2023, 80 CRC patients from our hospital's Colorectal Surgery Department were enrolled. A random number table was used to divide them into two categories. Both groups were subjected to distinct gastrointestinal preparation protocols. Indicators of clinical therapeutic effect, intestinal flora balance following surgery, post‐operative complications and quality of life were evaluated. The observation group, which adhered to a distinct gastrointestinal regimen, demonstrated a statistically significant improvement in post‐operative outcomes, with a clinical effectiveness rate of 97.5% compared to the control group's 75%. In addition, the observation group had a lower incidence of intestinal flora imbalance following surgery than the control group. The observation group had lower incidences of intestinal obstruction, infection, anastomotic leakage, incisional tumour implantation and delayed diarrhoea. Using the KPS score and the BMI, post‐treatment assessments of the observation group's quality of life revealed significant enhancements in comparison to the control group. Additionally, wound healing rates were superior in the observation group, with a correlation between stable intestinal flora and decreased wound infection rates. The type of post‐operative diet influenced the stabilization of the gut flora, with a high‐fibre diet producing superior results in both groups. The stability of intestinal flora influences the post‐operative rehabilitation of patients undergoing CRC surgery favourably. Appropriate bowel preparation and dietary considerations can reduce post‐operative complications, improve wound healing rates and enhance overall quality of life.
Anime as a medium for science learning
Authors: Mahler Leah S. , Mayer Richard E. 
Published: December 2023

AbstractBackgroundEmotional design of multimedia lessons involves adding features that are intended to increase learner enjoyment and promote learning—such as adding narrative, anthropomorphizing non‐human elements, and using warm colours.ObjectiveThe present study extends this work to examine the potential of Japanese animation (anime) for improving science learning.MethodSpecifically, 134 English‐speaking students learned about cells in the human body by viewing the popular anime, Cells at Work, either in Japanese with English subtitles or dubbed in English with no subtitles (anime groups), or by viewing a slideshow containing the same information (slideshow group). The anime conditions were vibrant story‐driven lessons that depicted human‐looking cells working to fight off invaders in a human body that looked like a city. The slideshow used very similar wording as the anime groups, and displayed the cells without anthropomorphism or a storyline.Results and ConclusionThe anime groups did not differ significantly from each other on any dependent measures and were therefore combined. The anime groups scored significantly higher than the slideshow group on retention (d = 0.35) and transfer (d = 0.48) tests. The anime groups also had significantly higher ratings of motivation (d = 0.60) and enjoyment (d = 1.13), whereas, the slideshow group had significantly higher ratings of distraction (d = 0.59). These results support the cognitive‐affective theory of learning with media (CATLM) and demonstrate that anime may be an effective learning medium.TakeawaysAnime should be considered as a medium for science learning, especially when students might not otherwise be motivated to learn.
Modeling and optimization of spray drying process parameters using artificial neural network and genetic algorithm for the production of probiotic (Lactiplantibacillus plantarum) finger millet milk powder
Authors: Yadav Shweta , Mishra Sabyasachi 
Published: December 2023

AbstractConsumers have been more inclined towards functional food due to various health issues. Non‐dairy‐based probiotic milk could be the potential alternative to fulfill consumer demand. Spray drying of functional health drinks could enhance the shelf life and reduce the transportation cost of developed food powder. The current study was focused on the modeling and optimization of spray‐drying process parameters using an artificial neural network (ANN) coupled with a genetic algorithm (GA). The data so obtained using ANN‐GA was also compared with the data obtained using response surface methodology (RSM) coupled with desirability function (DF). The results indicated that the ANN model was better at predicting the response parameters compared to the RSM model with a higher correlation coefficient (R) of .9997, .9994, .9964, and .9992 for training, testing, validation, and all datasets, respectively. The optimum conditions obtained using RSM‐DF were 160.41°C of inlet air temperature, 33.77% of maltodextrin content, and 138.79 mL/h of feed rate while that for ANN‐GA were 160.87°C, 20%, and 200 mL/h. The RSM‐DF method proved to be better for the optimization of response parameters. Therefore method selection for modeling and optimization of process and response parameters must be based on fulfilling the specific criteria.Practical ApplicationsNon‐dairy milk production has gained popularity in the area of research and product development. Various process protocols have been reported to produce high‐quality non‐dairy milk to fulfill the demand for a vegan diet. However, nutrient bioavailability, longer shelf life, product stability, and consumer acceptability are hard to obtain from cereal‐based non‐dairy milk. The current study contributes to produce spray‐dried milk powder followed by fermentation at optimum drying conditions with good quality and stability. The process has been modeled and optimized in the study using advanced statistical tools such as ANN‐GA and RSM‐DF. They can effectively predict the quality parameters and determine the optimal conditions for new experimental data.