bluuebunny/crossref_metadata_2025_split huggingface dataset:
Islamic versus conventional financial market: a meta-literature review of spillover effects
Authors: Foo Siong Min , Ab Razak Nazrul Hisyam , Kamarudin Fakarudin , Azizan Noor Azlinna Binti , Zakaria Nadisah 
Published: October 2023

Purpose
This study comprehensively aims to review the key influential and intellectual aspects of spillovers between Islamic and conventional financial markets.

Design/methodology/approach
The study uses the bibliometric and content analysis methods using the VOSviewer software to analyse 52 academic documents derived from the Web of Sciences (WoS) between 2015 and June 2022.

Findings
The results demonstrate the influential aspects of spillovers between Islamic and conventional financial markets, including the leading authors, journals, countries and institutions and the intellectual aspects of literature. These aspects are synthesised into four main streams: research between stock indexes; studies between stock indexes, oil and precious metal; works between Sukuk, bond and indexes; and empirical studies review. The authors also propose future research directions in spillovers between Islamic and conventional financial markets.

Research limitations/implications
Our study is subject to several limitations. Firstly, the authors only used the WoS database. Secondly, the study only includes papers and reviews written in English from the WoS. This study assists academic scholars, practitioners and regulatory bodies in further exploring the suggested issues in future studies and improving and predicting economic and financial stability.

Originality/value
To the best of the authors’ knowledge, no extant empirical studies have been conducted in this area of research interest.
The nature and fundamental elements of digital service innovation
Authors: Vargo Stephen L. , Fehrer Julia A. , Wieland Heiko , Nariswari Angeline 
Published: October 2023

PurposeThis paper addresses the growing fragmentation between traditional and digital service innovation (DSI) research and offers a unifying metatheoretical framework.Design/methodology/approachGrounded in service-dominant (S-D) logic's service ecosystems perspective, this study builds on an institutional and systemic, rather than product-centric and linear, conceptualization of value creation to offer a unifying framework for (digital) service innovation that applies to both physical and digital service provisions.FindingsThis paper questions the commonly perpetuated idea that DSI fundamentally changes the nature of innovation. Instead, it highlights resource liquification—the decoupling of information from the technologies that store, transmit, or process this information—as a distinguishing characteristic of DSI. Liquification, however, does not affect the relational and institutional nature of service innovation, which is always characterized by (1) the emergence of novel outcomes, (2) distributed governance and (3) symbiotic design. Instead, liquification makes these three characteristics more salient.Originality/value In presenting a cohesive service innovation framework, this study underscores that all innovation processes are rooted in combinatorial evolution. Here, service-providing actors (re)combine technologies (or more generally, institutions) to adapt their value cocreation practices. This research demonstrates that such (re)combinations exhibit emergence, distributed governance and symbiotic design. While these characteristics may initially seem novel and unique to DSI, it reveals that their fundamental mechanisms are not limited to digital service ecosystems. They are, in fact, integral to service innovation across virtual, physical and blended contexts. The study highlights the importance of exercising caution in assuming that the emergence of novel technologies, including digital technologies, necessitates a concurrent rethinking of the fundamental processes of service innovation.
A short peptide protects from age‐onset proteotoxicity
Authors: Elsana Hassan , Bruck‐Haimson Reut , Zhu Huadong , Siddiqui Atif Ahmed , Zaretsky Adam , Cohen Irit , Boocholez Hana , Roitenberg Noa , Moll Lorna , Plaschkes Inbar , Naor David , Cohen Ehud 
Published: October 2023

AbstractAberrant protein aggregation jeopardizes cellular functionality and underlies the development of a myriad of late‐onset maladies including Alzheimer's disease (AD) and Huntington's disease (HD). Accordingly, molecules that mitigate the toxicity of hazardous protein aggregates are of great interest as potential future therapeutics. Here we asked whether a small peptide, composed of five amino acids (5MER peptide) that was derived from the human pro‐inflammatory CD44 protein, could protect model nematodes from the toxicity of aggregative proteins that underlie the development of neurodegenerative disorders in humans. We found that the 5MER peptide mitigates the toxicity that stems from both; the AD‐causing Aβ peptide and a stretch of poly‐glutamine that is accountable for the development of several disorders including HD, while minimally affecting lifespan. This protection was dependent on the activity of aging‐regulating transcription factors and associated with enhanced Aβ and polyQ35‐YFP aggregation. A transcriptomic analysis unveiled that the peptide modifies signaling pathways, thereby modulating the expression of various genes, including these, which are known as protein homeostasis (proteostasis) regulators such as txt‐13 and modifiers of proteasome activity. The knockdown of txt‐13 protects worms from proteotoxicity to the same extent as the 5MER peptide, suggesting that the peptide activates the transcellular chaperone signaling to promote proteostasis. Together, our results propose that the 5MER peptide should be considered as a component of future therapeutic cocktails for the treatment of neurodegenerative maladies.
Risk of stillbirth and adverse pregnancy outcomes in a third pregnancy when an earlier pregnancy has ended in stillbirth
Authors: Al Khalaf Sukainah , Kublickiene Karolina , Kublickas Marius , Khashan Ali S. , Heazell Alexander E. P. 
Published: October 2023

AbstractIntroductionOur study evaluated how a history of stillbirth in either of the first two pregnancies affects the risk of having a stillbirth or other adverse pregnancy outcomes in the third subsequent pregnancy.Material and MethodsWe used the Swedish Medical Birth Register to define a population‐based cohort of women who had at least three singleton births from 1973 to 2012. The exposure of interest was a history of stillbirth in either of the first two pregnancies. The primary outcome was subsequent stillbirth in the third pregnancy. Secondary outcomes included: preterm birth, preeclampsia, placental abruption and small‐for‐gestational‐age infant. Adjusted logistic regression was performed including maternal age, body mass index, smoking, diabetes and hypertension. A sensitivity analysis was performed excluding stillbirths associated with congenital anomalies, pregestational and gestational diabetes, hypertension and preterm stillbirths.ResultsThe study contained data on 1 316 175 births, including 8911 stillbirths. Compared with women who had two live births, the highest odds of stillbirth in the third pregnancy were observed in women who had two stillbirths (adjusted odds ratio [aOR] 11.40, 95% confidence interval [95% CI] 2.75–47.70), followed by those who had stillbirth in the second birth (live birth–stillbirth) (aOR 3.59, 95% CI 2.58–4.98), but the odds were still elevated in those whose first birth ended in stillbirth (stillbirth–live birth) (aOR 2.35, 1.68, 3.28). Preterm birth, pre‐eclampsia and placental abruption followed a similar pattern. The odds of having a small‐for‐gestational‐age infant were highest in women whose first birth ended in stillbirth (aOR 1.93, 95% CI 1.66–2.24). The increased odds of having a stillbirth in a third pregnancy when either of the earlier births ended in stillbirth remained when stillbirths associated with congenital anomalies, pregestational and gestational diabetes, hypertension or preterm stillbirths were excluded. However, when preterm stillbirths were excluded, the strength of the association was reduced.ConclusionsEven when they have had a live‐born infant, women with a history of stillbirth have an increased risk of adverse pregnancy outcomes; this cannot be solely accounted for by the recurrence of congenital anomalies or maternal medical disorders. This suggests that women with a history of stillbirth should be offered additional surveillance for subsequent pregnancies.
Anxiety and depression among women with newly diagnosed vulvar cancer – A nationwide longitudinal study
Authors: Zach Diana , Jensen Pernille T. , Falconer Henrik , Kolkova Zuzana , Bohlin Katja Stenström , Kjølhede Preben , Åvall Lundqvist Elisabeth , Flöter Rådestad Angelique 
Published: October 2023

AbstractIntroductionOur objective was to investigate the trajectories of anxiety, depression, emotional and social functioning in women with newly diagnosed vulvar cancer from the time of diagnosis to 12 months after treatment. A further aim was to identify risk factors for high levels of anxiety.Material and methodsPROVE (PROspective Vulvar Cancer Evaluation) is a nationwide longitudinal cohort study investigating quality of life in women with newly diagnosed vulvar cancer by the following validated patient‐reported outcome measures at diagnosis, and 3 and 12 months after treatment: The Hospital Anxiety and Depression Scale, the European Organization for Research and Treatment of Cancer Quality of Life Questionnaire C30, and the European Organization for Research and Treatment of Cancer Quality of Life Questionnaire Vulvar module VU34. Mean scores, changes over time and associations were analyzed by generalized estimated equations and log‐linear regression models, adjusted for possible confounders.ResultsBetween 2019 and 2021, 105 (69%) women completed the questionnaires at all three time points. At diagnosis, 42% of the women reported elevated anxiety levels, decreasing significantly to 30% during the first 12 months. Insomnia, persisting vulvar symptoms and high information needs were significantly associated with a high level of anxiety (relative risk [RR] 2.1, 95% CI 1.2–3.7 for insomnia; RR 2.8, 95% CI 1.7–4.6 for vulvar symptoms, RR 2.7, 95% CI 1.5–4.9 for information needs). We found a trend towards a higher level of anxiety in younger women (<65 years: RR 1.5, 95% CI 1.0–2.5). Participants reported a low and stable prevalence of depression (14%) and high social functioning throughout the study period.ConclusionsWomen with newly diagnosed vulvar cancer report a high level of anxiety at diagnosis. Despite a significant improvement, anxiety remains widely prevalent during the first year of follow‐up. Targeting insomnia, vulvar symptoms and unmet needs may decrease anxiety during surveillance.
Sunflower cake versus soybean meal and alfalfa for nitrogen utilization when crude protein and non‐fiber carbohydrate levels are equivalent
Authors: Liu Chunyan , Asano Sanae , Ishii Nae , Kashimura Takuma , Niimi Keita , Nomizo Takuya , Numata Youichi , Takahashi Kei , Kajikawa Hiroshi 
Published: October 2023

AbstractThe reported efficiency of N usage by sunflower cake (SFC) was inferior to that of soybean meal (SBM) in a study in which the non‐fiber carbohydrate (NFC) content was lower in the SFC diet. Here, we adjusted crude protein (CP) and NFC levels to near‐equivalence among three diets containing SFC or SBM for four non‐lactating Holstein cows. Alfalfa hay was also added to the comparison. The results demonstrated that the total digestible nutrient contents were not significantly different among the diets. Intake N, fecal N, absorbed N, urinary N, and retained N did not differ significantly among the diets. The efficiency of N usage in the body (retained N/absorbed N) did not differ significantly among the diets. No between‐diet difference was observed in the protein‐ and energy‐related ruminal and blood properties, including the estimated microbial protein synthesis in the rumen. These results suggest that regardless of the quality and balance of amino acids in a feed, the efficiency of N usage can be improved by a supply of digestible carbohydrates, which leads to an increase in ruminal microbial protein.
Achieving active aging of older people with gratitude, independence, and government support—A biographical narrative approach
Authors: You Yong‐Lim , Han Jeong‐Eun , Kim Soo‐Young 
Published: October 2023

AbstractThis article aims to explore the perspectives and experiences of elderly individuals in Korea regarding active aging in their daily lives. The research utilizes Schütze's biographical narrative approach and involves six participants, comprising two males and four females aged between 73 and 82. The data collected undergoes analysis using Schütze's six‐step biographical narrative analysis method, resulting in the following key findings. The first significant finding in their biographical stories is that participants have gone through poverty, lack of education, economic activity, early marriage, dedicated child‐rearing, and the challenging times in Korea following the end of Japanese colonial rule and the Korean War. Secondly, the study discovered that older people could achieve a balanced and active life obtained from the love of family and friends, sincere faith, enjoyable social activities, precious jobs, and safety concerns by adopting a positive and appreciative approach toward life. The study's third finding highlights that older individuals wish to be self‐reliant, value government benefits, seek more economic opportunities, and need better social services to assist them during their vulnerable later years for active aging. Therefore, the thesis recommends that the Korean government provide older individuals with expanded healthcare management, caregiving services, and employment opportunities.
Identification and comparison of sex‐specific serious adverse drug reactions in spontaneous reports and systematically collected reports (ADRED)
Authors: Christ Patrick , Dubrall Diana , Just Katja Susanne , Lewke Britta , Below Maike , Stingl Julia Carolin , Schmid Matthias , Sachs Bernhardt 
Published: October 2023

AimsAdverse drug reactions (ADRs) are known to show sex‐specific differences in occurrence and phenotype. The aim of this study was to analyse sex‐specific differences in ADR–drug combinations that required hospitalization based on two different datasets.MethodsWe performed a complementary analysis of (i) spontaneously reported (n = 12 564, female = 51.7%) and (ii) systematically collected ADR reports from a prospective multicentre observational study (ADRED, n = 2355, female = 48.2%) from Germany in the ADR database EudraVigilance (EV). Both datasets were analysed separately concerning the suspected drugs, ADRs and ADR–drug combinations more frequently reported for females or males by calculating reporting odds ratios (ROR) with 95% confidence intervals. ADR–drug combinations more frequently reported for either females or males in EV reports were related to prescription data. Finally, the results from both datasets were discussed with regard to their (dis‐)concordance.ResultsIn both datasets, some antineoplastic agents and nervous system drugs were found to be reported more often for females than males (RORs ranging from 1.5 [1.1–2.1] for quetiapine in spontaneous reports to 41.3 [13.1–130.0] for trastuzumab in spontaneous reports). ADRs of the respiratory system, and haemorrhages were described predominantly for males in both datasets. In spontaneous reports the ADR–drug combination self‐injurious behaviour–quetiapine was more often reported for females without and with consideration of drug prescriptions (ROR: 3.8 [1.3–11.0]). Quetiapine and psychiatric disorders (superordinate level) was exclusively reported for females in ADRED reports.ConclusionsOur results can contribute to raise awareness and further knowledge regarding sex‐specific ADRs. The findings require further in‐depth investigation.
External validation of a pharmacokinetic model for target‐controlled infusion of cefazolin as a prophylactic antibiotic
Authors: Lee Sou Hyun , Yoon Hyeongseo , Park Junik , Choi Jae Moon , Kim Kyung Mi , Lee Eun‐Kyung , Noh Gyu‐Jeong , Moon Ju‐Yeon , Cho Byung‐Moon 
Published: October 2023

AimsThis study aimed to evaluate the predictive performance of previously constructed cefazolin pharmacokinetic models and determine whether cefazolin administration via the target‐controlled infusion (TCI) method may be possible in clinical practice.MethodsTwenty‐five gastrectomy patients receiving cefazolin as a prophylactic antibiotic were enrolled. Two grams of cefazolin was dissolved in 50 mL of normal saline to give a concentration of 40 mg mL−1. Before skin incision, cefazolin was administered using a TCI syringe pump, and its administration continued until the end of surgery. The target total plasma concentration was set to 100 μg mL−1. Total and unbound plasma concentrations of cefazolin were measured in three arterial blood samples collected at 30, 60 and 120 min after the start of cefazolin administration. The predictive performance of the TCI system was evaluated using four measures: inaccuracy, divergence, bias and wobble.ResultsTotal (n = 75) and unbound (n = 75) plasma concentration measurements from 25 patients were included in the analysis. The pooled median (95% confidence interval) biases and inaccuracies were 6.3 (4.0‐8.5) and 10.5 (8.6‐12.4) for the total concentration model and −10.3 (−16.8 to −3.7) and 22.4 (18.2‐26.7) for the unbound concentration model, respectively. All unbound concentrations were above 10 μg mL−1.ConclusionAdministration of cefazolin by the TCI method showed a clinically acceptable performance. Applying the TCI method by setting the total concentration as the target concentration rather than the unbound concentration is effective in maintaining a constant target concentration of cefazolin.
A novel link between melatonin and circ_0005753/PTBP1/TXNIP regulatory network in the modulation of osteogenic potential in mesenchymal stem cells
Authors: Tu Wei , Zhu Shuying , Li Fan , Xu Chengyun , Tu Weiping , Chen Yanxia 
Published: October 2023

AbstractLabeled with pluripotent potential, the transplantation of bone marrow mesenchymal stem cells (BMSCs) is considered as a promising strategy for treating osteoporosis (OP). Melatonin (MEL) has been investigated to be an essential regulator involved in bone metabolism, as well as BMSCs differentiation. Circular RNAs (circRNAs) are a unique kind of non‐coding RNA and play an important regulatory role in OP. However, whether circRNAs are implicated in the effects of MEL on BMSCs osteogenic differentiation remains largely indeterminate. Expression of circ_0005753 in human BMSCs with MEL treatment, clinical specimens diagnosed with OP, either with ovariectomy (OVX)‐induced mice, was measured by RT‐qPCR. Western blot was conducted to analyze protein levels of osteogenesis‐related molecules (Opg, RUNX2, ALP, BMP4) and TXNIP. RNA immunoprecipitation (RIP) and RNA pull‐down assays were performed to validate the binding relationship among circ_0005753, PTBP1, and TXNIP. Alkaline phosphatase (ALP) and alizarin red staining (ARS) were performed to evaluate osteogenic capacity of BMSCs. OP mouse model was established by ovariectomy, as evaluated pathologic changes via hematoxylin–eosin (HE), Masson, and Immunohistochemistry (IHC) staining. Expression of circ_0005753 was remarkably decreased during MEL‐induced osteogenic differentiation of BMSCs. Interestingly, not only circ_0005753 knockdown significantly promoted osteogenic differentiation of BMSCs, but circ_0005753 overexpression also weakened osteogenic differentiation induced by MEL treatment. Mechanistically, circ_0005753 maintained the stabilization of TXNIP mRNA via recruiting PTBP1. Additionally, reinforced circ_0005753 abrogated MEL‐mediated protective effects on OP pathogenesis in a mouse model. This work shows that MEL facilitates osteogenic differentiation of BMSCs via the circ_0005753/PTBP1/TXNIP axis, which may shed light on the development of a novel therapeutic strategy to prevent OP.
Does parent report of child physical abuse and supervisory neglect differ by method of study recruitment or mode of survey administration?
Authors: Freisthler Bridget , Kranich Christiana , Price Wolf Jennifer 
Published: October 2023

AbstractGeneral population studies find that rates of child maltreatment are higher than those identified in the child welfare system. Some modes of administration may result in higher disclosure rates of child maltreatment by respondents. This study assesses differences in characteristics of parents who are recruited using telephone sampling techniques or via the internet and whether the survey was administered by telephone or the web. We have 1599 parent respondents recruited from listed samples and Craigslist advertisements. Surveys were administered via the telephone or online. Survey included measures of parenting behaviours, psychosocial characteristics and demographics for the parent, child and family. Data were analysed using logit multilevel models. We found no differences between mode of administration and our child maltreatment and parenting measures, including physical abuse, corporal punishment and supervisory neglect. Recruitment strategy was not related to leaving a child home alone and corporal punishment. However, we did find that parents recruited by Craigslist use physical abuse more frequently. That we found no difference in use of punitive and neglectful parenting practices by survey mode of administration and recruitment method provides some degree of confidence that survey methods other than random‐digit‐dialling telephone surveys may result in generalizable samples in this age of declining landline use.
Feasibility of providing web‐based education to patients prior to kidney transplant evaluation
Authors: Kayler Liise K. , Nie Jing , Solbu Anne , Handmacher Matthew , Feeley Thomas H. , Noyes Katia 
Published: October 2023

AbstractBackgroundWe previously developed web‐based education to be used by patients prior to kidney transplant (KTX) evaluation. The current feasibility study evaluated patients’ intervention uptake and barriers, and staff experiences of the clinic‐wide implementation in preparation for a definitive comparative effectiveness trial.MethodsWeb links and login instructions to view 17 educational videos designed to promote KTX access were delivered via email or text to adults referred to a single transplant center between 10/2020 and 3/2021. Patient barriers were recorded. Non‐completers were allowed to view the resources in the clinic. N = 7 clinic staff were interviewed about their experiences of in‐clinic delivery of the web‐education. Interviews were recorded with field notes and coded using simple content analysis. Patient characteristics and 30‐month KTX access were examined with Chi‐square, t‐tests, and log‐rank tests.ResultsOf 210 patients, 71% completed the self‐education remotely (completers), 16% attempted but did not complete remotely (attempters), and 13% declined the web link invitation (decliners). Implementation barriers included technology access and use difficulties, unstable internet connectivity, limited staff time in clinic to facilitate technology use by patients, and limited technology attentiveness by patients in clinic. In 3‐group comparisons, remote decliners were older with worse estimated posttransplant survival scores, and attempters were younger, more often Medicaid insured, and lived in higher area deprivation; both were more often deemed ineligible for KTX than completers. Between‐group time‐to‐transplantation was non‐significant (p = .571).ConclusionThe majority of patients accessed the web‐education remotely; however, more vulnerable demographic populations reported greater problems accessing web‐education. In‐clinic delivery was burdensome to staff and patients. Future adaptive implementation strategies are needed to allow for adequate patient education.