bluuebunny/crossref_metadata_2025_split huggingface dataset:
Study of White and Blue Pottery in the Safavid Period
Authors: Ebrahimi Fereshteh , Ebrahimi Khalil 
Published: October 2023

Art and the craft of pottery have always held a significant place in addressing human needs. Throughout different eras and societies, we have witnessed the growth, development, and significant influences of pottery on the richness and prosperity of culture and the general economy. This art and craft have endured and evolved over time. The continuation and evolution of blue and white pottery during the Safavid period highlight the importance of this pottery style. The transformative developments and support from the Safavid kings, especially Shah Abbas, led to the exquisite production of blue and white pottery during this period. In reality, the distinctive characteristics and quality in the creation of this type of pottery, along with the high demand in global markets, contributed to its mass production. The aim of this study is to elucidate the method of creating blue and white pottery during the Safavid period, introduce the influential factors in enhancing this type of pottery, and recognize its specific features.
The research methodology employed in this study is descriptive-analytical, and the data collection method is primarily documentary (library-based). The examination and analysis of blue and white pottery demonstrate that Iranian potters during the Safavid period, drawing upon their experiences in creating pottery from the previous Timurid era, imitated and combined these techniques with Ming Chinese examples and familiarized themselves with Ottoman pottery specimens. This resulted in a new style of blue and white pottery with distinct Iranian characteristics. The colors of this pottery typically feature a white body with blue patterns. Decorative motifs were tailored to the vessel's form, where primary designs such as animals, human figures, and plant patterns adorned the center of the vessel, while abstract patterns, calligraphy, and natural elements embellished the vessel's margins. These vessels were primarily utilized for storing liquids, serving food, and as decorative ceramics.
Effect of premolar extraction and anchorage type for orthodontic space closure on upper airway dimensions and position of hyoid bone in adults: a retrospective cephalometric assessment
Authors: Mortezai Omid , Shalli Zeynab , Tofangchiha Maryam , Alizadeh Ahad , Pagnoni Francesco , Reda Rodolfo , Testarelli Luca 
Published: October 2023

Background
This study aimed to assess the effect of premolar extraction and anchorage type for orthodontic space closure on upper airway dimensions and position of hyoid bone in adults by cephalometric assessment.

Methods
This retrospective study was conducted on 142 cephalograms of patients who underwent orthodontic treatment with premolar extraction in four groups of (I) 40 class I patients with bimaxillary protrusion and maximum anchorage, (II) 40 class I patients with moderate crowding and anchorage, (III) 40 class II patients with maximum anchorage, and (IV) 22 skeletal class III patients with maximum anchorage. The dimensions of the nasopharynx, velopharynx, oropharynx, and hypopharynx, and hyoid bone position were assessed on pre- and postoperative lateral cephalograms using AudaxCeph v6.1.4.3951 software. Data were analyzed by the Chi-square test, paired t-test, and Pearson’s correlation test (alpha = 0.05).

Results
A significant reduction in oropharyngeal, velopharyngeal, and hypopharyngeal airway dimensions was noted in groups I, III, and IV (P < 0.001), which was correlated with the magnitude of retraction of upper and lower incisors (r = 0.6 − 0.8). In group II, a significant increase was observed in oropharyngeal and velopharyngeal dimensions (P < 0.001). A significant increase in nasopharyngeal dimensions occurred in all groups (P < 0.001). Also, in groups I and III, the position of hyoid bone changed downwards and backwards, which was correlated with reduction in airway dimensions (r = 0.4 − 0.6).

Conclusion
According to the present results, extraction orthodontic treatment affects upper airway dimensions and hyoid bone position. Maximum anchorage decreases airway dimensions while moderate anchorage increases airway dimensions.
Hospital Admissions for Abusive Head Trauma Before and During the COVID-19 Pandemic
Authors: Maassel Nathan L. , Graetz Elena , Schneider Eric B. , Asnes Andrea G. , Solomon Daniel G. , Leventhal John M. 
Published: October 2023

ImportanceSeveral studies have demonstrated a decrease in the occurrence of child abuse in the US since the start of the COVID-19 pandemic. This finding has generated concern for missed cases due to the initial lockdowns and lack of childcare resources. Determining the association of the pandemic on hospitalizations for severe forms of abuse is essential to focus preventive efforts.ObjectiveTo examine trends in abusive head trauma (AHT) before and during the COVID-19 pandemic.Design, Setting, and ParticipantsRetrospective, multicenter, repeated cross-sectional study, conducted January 1, 2016, through April 30, 2022, with data from tertiary care children’s hospitals and contributors to the Pediatric Health Information System. Data were obtained for 2380 hospitalizations of children younger than 5 years with International Classification of Diseases, Tenth Revision, Clinical Modification codes for both abuse and head trauma.Main Outcomes and MeasuresMonthly hospitalizations were analyzed using interrupted time-series analysis. Hospitalization severity (eg, intensive care unit stay) and clinical characteristics (subdural hemorrhages and retinal hemorrhages) were compared before and after the start of the pandemic.ResultsWe identified 2380 hospitalizations due to AHT (median age, 140 [IQR, 75.0-325.5] days) from 45 hospitals. The mean (SD) monthly incidence of AHT was 34.3 (5.8) before the COVID-19 pandemic compared with 25.6 (4.2) during COVID-19 (a 25.4% decrease). When the pre–COVID-19 and during COVID-19 periods were compared, there were no significant differences in severity or clinical characteristics. On interrupted time-series analysis, there was a significant decrease in the number of monthly hospitalizations (−8.1; 95% CI, −12.41 to −3.72; P &amp;lt; .001) in the first month of the pandemic. In the subgroup of children younger than 1 year, there was a significant decrease in monthly hospitalizations at the onset of the pandemic (−8.2; 95% CI, −12.02 to −4.43; P &amp;lt; .001) followed by a significant temporal increase across the COVID-19 period (P = .01).Conclusions and RelevanceThe findings of this cross-sectional study suggest there was a significant decrease in monthly hospitalizations for AHT following the start of the pandemic in March 2020. Although there was no corresponding increase in hospitalization severity, the decrease during the pandemic may have been transient, as monthly hospitalizations for children younger than 1 year increased significantly over time during COVID-19, after the initial decrease.
Insight into Tetrabromobisphenol A‐Associated Liver Transcriptional Landscape via Single Cell RNA Sequencing
Authors: Bai Yunmeng , Zhu Zhou , Ou Jinhuan , Zhang Wenqiao , Iyaswamy Ashok , Jiang Yuke , Wang Jigang , Zhang Wei , Yang Chuanbin 
Published: October 2023

AbstractIn recent years, there has been growing concern over the rising incidence of liver diseases, with increasing exposure to environmental toxins as a significant contributing factor. However, the mechanisms of liver injury induced by environmental pollutants are largely unclear. Here, using tetrabromobisphenol A (TBBPA), a widely used brominated flame retardant, as an example, environmental toxin‐induced liver toxicity in mice is characterized via single‐cell sequencing technology. Heterogeneous gene expression profiles after exposure to TBBPA in major cell types of the liver are demonstrated. In hepatocytes, pathway analysis of differentially expressed genes reveals the enhanced interferon response and diminished metabolic processes. The disrupted endothelial functions in TBBPA‐treated cells are then shown. Moreover, the activation of M2‐polarization in Kupffer cells, as well as activated effector T and B cells are unveiled in TBBPA‐treated cells. Finally, ligand‐receptor pair analysis shows that TBBPA disrupts cell‐cell communication and induces an inflammatory microenvironment. Overall, the results reveal that TBBPA‐induced dysfunction of hepatocytes and endothelial cells may then activate and recruit other immune cells such as Kuffer cells, and T/NK cells into the liver, further increasing inflammatory response and liver injury. Thus, the results provide novel insight into undesiring environmental pollutant‐induced liver injury.
Insight into Grain and Grain‐Boundary Transport of Proton‐Conducting Ceramics: A Case Report of BaSn0.8Y0.2O3−δ
Authors: Starostina Inna A. , Starostin George N. , Akopian Mariam T. , Vdovin Gennady K. , Osinkin Denis A. , Py Baptiste , Maradesa Adeleke , Ciucci Francesco , Medvedev Dmitry A. 
Published: October 2023

AbstractProton‐conducting ceramic electrolytes offer great potential for the development of low‐ and intermediate‐temperature solid oxide electrochemical devices, e.g., fuel cells and electrolyzers. However, the electrolyte constitutes the main bottleneck in such devices, especially at reduced temperatures, determining their overall performance and efficiency. Herein, for the first time the low‐temperature transport properties of BaSn0.8Y0.2O3−δ as a representative of proton‐conducting materials are investigated. The attention is focussed on grain and grain boundary conductivity of this ceramic material over a wide range of experimental conditions, including temperatures of 400–550 °C, oxygen partial pressures of 10−22–0.21 atm, and water vapor partial pressures of 10−5‐0.03 atm. After analyzing BaSn0.8Y0.2O3−δ with electrochemical impedance spectroscopy under these experimental conditions, the distribution of relaxation times is leveraged to evaluate the resistance, capacitance, and frequency of each electrolytic process. The data show that the BSY ceramic, prepared with CuO as a sintering additive, is characterized by three distinct processes: one is due to grain response, and two others are understood to be related to the responses of the pure and CuO‐covered grain boundaries. Therefore, this work opens a new path for the analysis of ionic, including protonic, transport along grains and grain boundaries.
Perspectives of High‐Performance Li–S Battery Electrolytes
Authors: Liu Jing , Zhou Yuhao , Yan Tianying , Gao Xue‐Ping 
Published: October 2023

AbstractLithium–sulfur batteries with high energy density are considered to be one of the most promising candidates for the next‐generation energy storage devices. Electrolyte as the medium for Li+ transportation between the electrodes, also plays a crucial role in inhibiting the dissolution and diffusion of lithium polysulfides in Li–S batteries. The working mechanism of Li–S batteries in different electrolytes is classified into “solid‐liquid‐solid” and “solid‐solid” conversions. Under the “solid‐liquid‐solid” conversion, Li–S batteries would inevitably face the challenges such as “shuttle effect” that lead to poor cycle performance, and under the “solid‐solid” conversion, they would face interface mismatch that limits the utilization of sulfur with low energy density, while both conversion mechanisms cause uncontrollable Li dendrites on anode. According to the conversion mechanism, electrolytes can be divided into ether‐based, ionic liquid‐based, gel polymer electrolytes, and polymer‐based solid‐state electrolytes with “solid‐liquid‐solid” conversion, as well as carbonate‐based electrolytes and oxide/sulfide‐based solid‐state electrolytes with “solid‐solid” conversion. Based on the conversion mechanism of active materials in different electrolytes, the current status on the strategies from multiple perspectives are summarized to improve the electrochemical performance, with the hope to provide a comprehensive guideline toward the development of suitable electrolytes for Li–S batteries.
Percutaneous Intratumoral Immunoadjuvant Gel Increases the Abscopal Effect of Cryoablation for Checkpoint Inhibitor Resistant Cancer
Authors: Som Avik , Rosenboom Jan‐Georg , Wehrenberg‐Klee Eric , Chandler Alana , Ndakwah Gabrielle , Chen Eric , Suggs Jack , Morimoto Joshua , Kim Jonathan , Mustafa Abdul Rehman , Marcos‐Vidal Asier , Fintelmann Florian J. , Basu Arijit , Langer Robert , Traverso Giovanni , Mahmood Umar 
Published: October 2023

AbstractPercutaneous cryoablation is a common clinical therapy for metastatic and primary cancer. There are rare clinical reports of cryoablation inducing regression of distant metastases, known as the “abscopal” effect. Intratumoral immunoadjuvants may be able to augment the abscopal rate of cryoablation, but existing intratumoral therapies suffer from the need for frequent injections and inability to confirm target delivery, leading to poor clinical trial outcomes. To address these shortcomings, an injectable thermoresponsive gel‐based controlled release formulation is developed for the FDA‐approved Toll‐like‐receptor 7 (TLR7) agonist imiquimod (“Imigel”) that forms a tumor‐resident depot upon injection and contains a contrast agent for visualization under computed tomography (CT). The poly‐lactic‐co‐glycolic acid‐polyethylene glycol‐poly‐lactic‐co‐glycolic acid (PLGA‐PEG‐PLGA)‐based amphiphilic copolymer gel's underlying micellar nature enables high drug concentration and a logarithmic release profile that is additive with the neo‐antigen release from cryoablation, requiring only a single injection. Rheological testing demonstrated the thermoresponsive increase in viscosity at body temperature and radio‐opacity via microCT. Its ability to significantly augment the abscopal rate of cryoablation is demonstrated in otherwise immunotherapy resistant metastatic tumors in two aggressive colorectal and breast cancer dual tumor models with an all or nothing response, responders generally demonstrating complete regression of bilateral tumors in 90‐day survival studies.
FLight Biofabrication Supports Maturation of Articular Cartilage with Anisotropic Properties
Authors: Puiggalí‐Jou Anna , Rizzo Riccardo , Bonato Angela , Fisch Philipp , Ponta Simone , Weber Daniel M. , Zenobi‐Wong Marcy 
Published: October 2023

AbstractTissue engineering approaches that recapitulate cartilage biomechanical properties are emerging as promising methods to restore the function of injured or degenerated tissue. However, despite significant progress in this research area, the generation of engineered cartilage constructs akin to native counterparts still represents an unmet challenge. In particular, the inability to accurately reproduce cartilage zonal architecture with different collagen fibril orientations is a significant limitation. The arrangement of the extracellular matrix (ECM) plays a fundamental role in determining the mechanical and biological functions of the tissue. In this study, it is shown that a novel light‐based approach, Filamented Light (FLight) biofabrication, can be used to generate highly porous, 3D cell‐instructive anisotropic constructs that lead to directional collagen deposition. Using a photoclick‐based photoresin optimized for cartilage tissue engineering, a significantly improved maturation of the cartilaginous tissues with zonal architecture and remarkable native‐like mechanical properties is demonstrated.
Superhydrophilic/Superhydrophobic Droplet Microarrays of Low Surface Tension Biofluids for Nucleic Acid Detection
Authors: Awashra Mohammad , Elomaa Pinja , Ojalehto Tuomas , Saavalainen Päivi , Jokinen Ville 
Published: October 2023

AbstractSuperhydrophilic/superhydrophobic patterned surfaces can be used to create droplet microarrays. A specific challenge with the liquids needed for various biomedical applications, as compared to pure water, is their lower surface tension and potential for contaminating the surfaces through adsorption. Here, a method is shown to create biofluid droplet microarrays using discontinuous dewetting of pure water, an oil protective layer, and finally biofluid exchange with the water droplet array. With this method, a droplet array of a viscous nucleic acid amplification solution can be formed with a low surface tension of 34 mN m−1 and a contact angle of only 76° with the used hydrophobic coating. This droplet array is applied for nucleic acid detection of SARS‐CoV‐2 virus using strand invasion‐based amplification (SIBA) technology. It is shown that by using an array of 10 000 droplets of 50 µm diameter the limit of detection is 1 RNA copy µL−1. The results demonstrate that SIBA on droplet microarrays may be a quantitative technology.
Anchoring Microbubbles on Cerebrovascular Endothelium as a New Strategy Enabling Low‐Energy Ultrasound‐Assisted Delivery of Varisized Agents Across Blood‐Brain Barrier
Authors: Li Bo , Lin Yuejun , Chen Gengjia , Cai Mingyue , Zhong Huihai , Xiao Zecong , Lin Minzhao , Li Tan , Cai Yujun , Shuai Xintao , Ren Jie 
Published: October 2023

AbstractThe protective blood‐brain barrier (BBB) prevents most therapeutic agents from entering the brain. Currently, focused ultrasound (FUS) is mostly employed to create microbubbles that induce a cavitation effect to open the BBB. However, microbubbles pass quickly through brain microvessels, substantially limiting the cavitation effect. Here, we constructed a novel perfluoropropane‐loaded microbubble, termed ApoER‐Pep‐MB, which possessed a siloxane bonds‐crosslinked surface to increase the microbubble stability against turbulence in blood circulation and was decorated with binding peptide for apolipoprotein E receptor (ApoER‐Pep). The microbubble with tailor‐made micron size (2 µm) and negative surface charge (−30 mV) performed ApoER‐mediated binding rather than internalization into brain capillary endothelial cells. Consequently, the microbubble accumulated on the brain microvessels, based on which even a low‐energy ultrasound with less safety risk than FUS, herein diagnostic ultrasound (DUS), could create a strong cavitation effect to open the BBB. Evans Blue and immunofluorescence staining studies demonstrated that the DUS‐triggered cavitation effect not only temporarily opened the BBB for 2 h but also caused negligible damage to the brain tissue. Therefore, various agents, ranging from small molecules to nanoscale objects, can be efficiently delivered to target regions of the brain, offering tremendous opportunities for the treatment of brain diseases.
An Ultraflexible Electrode Array for Large‐Scale Chronic Recording in the Nonhuman Primate Brain
Authors: Tian Yixin , Yin Jiapeng , Wang Chengyao , He Zhenliang , Xie Jingyi , Feng Xiaoshan , Zhou Yang , Ma Tianyu , Xie Yang , Li Xue , Yang Tianming , Ren Chi , Li Chengyu , Zhao Zhengtuo 
Published: October 2023

AbstractSingle‐unit (SU) recording in nonhuman primates (NHPs) is indispensible in the quest of how the brain works, yet electrodes currently used for the NHP brain are limited in signal longevity, stability, and spatial coverage. Using new structural materials, microfabrication, and penetration techniques, we develop a mechanically robust ultraflexible, 1 µm thin electrode array (MERF) that enables pial penetration and high‐density, large‐scale, and chronic recording of neurons along both vertical and horizontal cortical axes in the nonhuman primate brain. Recording from three monkeys yields 2,913 SUs from 1,065 functional recording channels (up to 240 days), with some SUs tracked for up to 2 months. Recording from the primary visual cortex (V1) reveals that neurons with similar orientation preferences for visual stimuli exhibited higher spike correlation. Furthermore, simultaneously recorded neurons in different cortical layers of the primary motor cortex (M1) show preferential firing for hand movements of different directions. Finally, it is shown that a linear decoder trained with neuronal spiking activity across M1 layers during monkey's hand movements can be used to achieve on‐line control of cursor movement. Thus, the MERF electrode array offers a new tool for basic neuroscience studies and brain–machine interface (BMI) applications in the primate brain.
Transition Metal High‐Entropy Nanozyme: Multi‐Site Orbital Coupling Modulated High‐Efficiency Peroxidase Mimics
Authors: Feng Jianxing , Yang Xuewei , Du Ting , Zhang Liang , Zhang Pengfei , Zhuo Junchen , Luo Linpin , Sun Hao , Han Yaru , Liu Lizhi , Shen Yizhong , Wang Jianlong , Zhang Wentao 
Published: October 2023

AbstractStrong substrate affinity and high catalytic efficiency are persistently pursued to generate high‐performance nanozymes. Herein, with unique surface atomic configurations and distinct d‐orbital coupling features of different metal components, a class of highly efficient MnFeCoNiCu transition metal high‐entropy nanozymes (HEzymes) is prepared for the first time. Density functional theory calculations demonstrate that improved d‐orbital coupling between different metals increases the electron density near the Fermi energy level (EF) and shifts the position of the overall d‐band center with respect to EF, thereby boosting the efficiency of site‐to‐site electron transfer while also enhancing the adsorption of oxygen intermediates during catalysis. As such, the proposed HEzymes exhibit superior substrate affinities and catalytic efficiencies comparable to that of natural horseradish peroxidase (HRP). Finally, HEzymes with superb peroxidase (POD)‐like activity are used in biosensing and antibacterial applications. These results suggest that HEzymes have great potential as new‐generation nanozymes.
Actomyosin Activity and Piezo1 Activity Synergistically Drive Urinary System Fibroblast Activation
Authors: Chen Guo , Gao Xiaoshuai , Chen Jiawei , Peng Liao , Chen Shuang , Tang Cai , Dai Yi , Wei Qiang , Luo Deyi 
Published: October 2023

AbstractMechanical cues play a crucial role in activating myofibroblasts from quiescent fibroblasts during fibrosis, and the stiffness of the extracellular matrix is of significant importance in this process. While intracellular force mediated by myosin II and calcium influx regulated by Piezo1 are the primary mechanisms by which cells sense and respond to mechanical forces, their intercellular mechanical interaction remains to be elucidated. Here, hydrogels with tunable substrate are used to systematically investigate the crosstalk of myosin II and Piezo1 in fibroblast to myofibroblast transition (FMT). The findings reveal that the two distinct signaling pathways are integrated to convert mechanical stiffness signals into biochemical signals during bladder‐specific FMT. Moreover, it is demonstrated that the crosstalk between myosin II and Piezo1 sensing mechanisms synergistically establishes a sustained feed‐forward loop that contributes to chromatin remodeling, induces the expression of downstream target genes, and ultimately exacerbates FMT, in which the intracellular force activates Piezo1 by PI3K/PIP3 pathway‐mediated membrane tension and the Piezo1‐regulated calcium influx enhances intracellular force by the classical FAK/RhoA/ROCK pathway. Finally, the multifunctional Piezo1 in the complex feedback circuit of FMT drives to further identify that targeting Piezo1 as a therapeutic option for ameliorating bladder fibrosis and dysfunction.