bluuebunny/crossref_metadata_2025_split huggingface dataset:
Genotypic and phenotypic characterization ofEnterococcus faecalisisolates from periprosthetic joint infections
Authors: Haeberle Amanda , Greenwood-Quaintance Kerryl , Zar Sarah , Johnson Stephen , Patel Robin , Willett Julia L. E. 
Published: February 2024

AbstractOver 2.5 million prosthetic joint implantation surgeries occur annually in the United States. Periprosthetic joint infections (PJIs), though occurring in only 1-2% of patients receiving replacement joints, are challenging to diagnose and treat and are associated with significant morbidity. The Gram-positive bacteriumEnterococcus faecalis, which can be highly antibiotic resistant and is a robust biofilm producer on indwelling medical devices, accounts for 2-11% of PJIs.E. faecalisPJIs are understudied compared to those caused by other pathogens, such asStaphylococcus aureus. This motivates the need to generate a comprehensive understanding ofE. faecalisPJIs to guide future treatments for these infections. To address this, we describe a panel ofE. faecalisstrains isolated from the surface of prosthetic joints in a cohort of individuals treated at Mayo Clinic in Rochester, MN. Here, we present the first complete genome assemblage ofE. faecalisPJI isolates. Comparative genomics shows differences in genome size, virulence factors, antimicrobial resistance genes, plasmids, and prophages, underscoring the genetic diversity of these strains. These isolates have strain-specific differences inin vitrobiofilm biomass, biofilm burden, and biofilm morphology. We measured robust changes in biofilm architecture and aggregation for all isolates when grown in simulated synovial fluid (SSF). Lastly, we evaluated antibiotic efficacy of these isolates and found strain specific changes across all strains when grown in SSF. Results of this study highlight the existence of genetic and phenotypic heterogeneity amongE. faecalisPJI isolates which will provide valuable insight and resources for futureE. faecalisPJI research.ImportancePeriprosthetic joint infections (PJIs) affect ∼1-2% of those who undergo joint replacement surgery.Enterococcus faecalisis a Gram-positive opportunistic pathogen that causes ∼10% of PJIs in the United States each year, but our understanding of how and whyE. faecaliscauses PJIs is limited.E. faecalisinfections are typically biofilm associated and can be difficult to clear with antibiotic therapy. Here, we provide complete genomes for fourE. faecalisPJI isolates from the Mayo Clinic. These isolates have strain-specific differences in biofilm formation, aggregation, and antibiotic susceptibility in simulated synovial fluid. These results provide important insight into genomic and phenotypic features ofE. faecalisisolates from PJI.
Truncated stochastically switching processes
Authors: Bressloff Paul C. 
Published: February 2024

There are a large variety of hybrid stochastic systems that couple a continuous process with some form of stochastic switching mechanism. In many cases the system switches between different discrete internal states according to a finite-state Markov chain, and the continuous dynamics depends on the current internal state. The resulting hybrid stochastic differential equation (hSDE) could describe the evolution of a neuron's membrane potential, the concentration of proteins synthesized by a gene network, or the position of an active particle. Another major class of switching system is a search process with stochastic resetting, where the position of a diffusing or active particle is reset to a fixed position at a random sequence of times. In this case the system switches between a search phase and a reset phase, where the latter may be instantaneous. In this paper, we investigate how the behavior of a stochastically switching system is modified when the maximum number of switching (or reset) events in a given time interval is fixed. This is motivated by the idea that each time the system switches there is an additive energy cost. We first show that in the case of an hSDE, restricting the number of switching events is equivalent to truncating a Volterra series expansion of the particle propagator. Such a truncation significantly modifies the moments of the resulting renormalized propagator. We then investigate how restricting the number of reset events affects the diffusive search for an absorbing target. In particular, truncating a Volterra series expansion of the survival probability, we calculate the splitting probabilities and conditional MFPTs for the particle to be absorbed by the target or exceed a given number of resets, respectively.

Published by the American Physical Society
2024
Unraveling the transformation: the three-wave time-lagged study on big data analytics, green innovation and their impact on economic and environmental performance in manufacturing SMEs
Authors: Mehmood Khalid , Jabeen Fauzia , Rashid Md , Alshibani Safiya Mukhtar , Lanteri Alessandro , Santoro Gabriele 
Published: February 2024

PurposeThe firms’ adoption and improvement of big data analytics capabilities to improve economic and environmental performance have recently increased. This makes it important to discover the underlying mechanism influencing the association between big data analytics (BDA) and economic and environmental performance, which is missing in the existing literature. The present study discovers the indirect effect of green innovation (GI) and the moderating role of corporate green image (CgI) on the impact of BDA capabilities, including big data management capability (MC) and big data talent capability (TC), on economic and environmental performance.Design/methodology/approachA time-lagged design was employed to collect data from 417 manufacturing firms, and study hypotheses were evaluated using Mplus.FindingsThe empirical outcomes indicate that both BDA capabilities of firms significantly influence green innovation (GI), which significantly mediates the relationship between BDA and economic and environmental performance. Our findings also revealed that CgI strengthened the effect of GI on economic and environmental performance. The empirical evidence provides important theoretical and practical repercussions for manufacturing SMEs and policymakers.Originality/valueThis study contributes to the literature on BDA by empirically exploring the effects of MC and TC on improving the EcP and EnP of manufacturing firms. It does so through the indirect impact of GIs and the moderating effect of CgI, thereby extending the Dynamic capabilities view (DCV) paradigm.
Exploring flexible working practices and the digital divide in a post-lockdown era
Authors: Soga Lebene Richmond , Bolade-Ogunfodun Yemisi , De Amicis Anna 
Published: February 2024

PurposeThis paper explores flexible working practices (FWPs) and takes a critical view that argues a need to consider not only access to digital technological resources but also the vast array of factors that constrain one’s ability to use technology for its intended benefits, as constituting the digital divide post-COVID-19 lockdown.Design/methodology/approachUsing a critical evaluation of the extant literature, we engage in a conceptual undertaking to develop theoretical propositions that form the basis for future empirical undertakings. To theoretically ground the arguments raised, we deploy the ontological lens of actor-network theory to illuminate the socio-technical dimensions of the digital divide in light of FWPs.FindingsSince the COVID-19 pandemic, the need to adopt socially distanced work practices has become a reality for many organisations. We find that the adoption of FWPs, enabled by digital technologies, simultaneously signals hidden inequalities. We also develop a conceptual framework which depicts user responses in different technology environments that can either be limiting or enabling for individuals’ work productivity.Originality/valueWith regards to the digital divide, attention has often focused on access to digital technologies, as the term “digital divide” portrays. The implication is that the array of factors and resources that individuals are heterogeneously networked to, which also constitute the digital divide, is often taken for granted. We take a different ontological view that brings to the fore other factors at play within an individual’s network of relations.
Theorising worker voice for supply chain justice – communication, representation and recognition
Authors: Stephens Victoria , Benstead Amy Victoria , Goworek Helen , Charles Erica , Lukic Dane 
Published: February 2024

PurposeThe paper explores the notion of worker voice in terms of its implications for supply chain justice. The paper proposes the value of the recognition perspective on social justice for framing workers’ experiences in global supply chains and identifies opportunities for the advancement of the worker voice agenda with recognition justice in mind.Design/methodology/approachThe paper adopts a conceptual approach to explore the notion of worker voice in supply chains in terms of the recognition perspective on social justice.FindingsSustainable supply chain management (SSCM) scholarship has considered worker voice in terms of two key paradigms, which we term communication and representation. To address recognition justice for workers in global supply chains, the worker voice agenda must consider designing worker voice mechanisms to close recognition gaps for workers with marginalised identities; the shared responsibilities of supply chain actors to listen alongside the expectation of workers to use their voice; and the expansion of the concept of worker voice to cut across home-work boundaries.Originality/valueThe paper offers conceptual clarity on the emerging notion of worker voice in SSCM and is the first to interrogate the implications of recognition justice for the emergent worker voice agenda. It articulates key opportunities for future research to further operationalise worker voice upon a recognition foundation.
Commuting and its relationship with health and engagement of civil construction workers
Authors: dos Santos Júlia Barros , Macedo Nascimento Paulo Marcelo , Lima Josiane Palma 
Published: February 2024

Purpose
Identifying factors that impact workers’ health and performance is extremely important for companies and, in particular, for companies in the construction sector. Despite the evidence, knowledge about the relationship between commuting, health and worker performance is still limited. More specifically on the relationship with work engagement, studies focus on work-related aspects, neglecting individual and behavioral factors. This study aims to verify the relationship between the commuting patterns of workers, their health and their work engagement in a civil construction company located in São José dos Campos, Brazil.

Design/methodology/approach
A structured questionnaire was applied to 43 civil construction workers. The participants’ physical and mental health was evaluated using the 12-item short-form health survey. Employees’ work engagement was assessed through the UWES-17 scale. A descriptive statistical analysis was performed on the relationship between physical and mental health, engagement and commuting to work.

Findings
The result corroborated the literature showing that the use of active transport positively influenced the mental health of construction workers and negatively affected those who use individual motorized transport. People working from home had the lowest values for total engagement, vigor and dedication.

Originality/value
This study provides evidence and a prior understanding of this relationship, serving as a basis for decision-making processes in the area of transport that contribute to the health and better functioning of companies in the construction sector. This work also contributes to the state of the art on the relationship between commuting, health and worker engagement.
More knowledge, better innovation? Role of knowledge breadth and depth
Authors: Wang Wei , Yin Ximing , Coles Ryan , Chen Jin 
Published: February 2024

PurposeCurrent open innovation (OI) and external knowledge search (EKS) research primarily shows a positive linear relationship between EKS and innovation at an individual level. However, organizational scholarship argues that excessive EKS may harm innovation. This study combines the knowledge-based view (KBV) and attention-based view (ABV) to articulate a nonlinear theory of EKS and innovation at the individual level.Design/methodology/approachThe authors constructed a multi-sourced dataset covering 59,798 USA pharmaceutical patents spanning from 1975 to 2014 and employed negative binomial fixed-effect models to examine theoretical hypotheses.FindingsWe find a significant concave curvilinear relationship between EKS and innovation quantity as well as innovation quality at an individual level. An individual’s knowledge breadth and depth moderate the relationship between EKS and innovation, such that the threshold at which EKS has diminishing returns for individual innovation is higher for inventors with a broad range of knowledge and those with deeper expertise in the domain where they are innovating.Research limitations/implicationsManagers should guide inventors toward a moderate investment of time and effort in EKS and should caution against over searching. Besides, managers should recognize that an inventor’s capacity for EKS is determined in part by their breadth of knowledge across various domains as well as the depth of knowledge they have in the knowledge domain where they are innovating.Practical implicationsWe provide both parties with a clearer understanding of when EKS can begin to deteriorate an individual’s innovation performance why that deterioration occurs, and we also highlight two individual-level knowledge characteristics to take into consideration when deciding when to cease the EKS process.Social implicationsThis study provides a novel holistic understanding of OI and knowledge management for policymakers and organizations to nourish innovation dynamism and make the best of knowledge stocks in the community, which in turn will create endless power for sustainable social change and inclusive development.Originality/valueThis study contributes to OI theory by highlighting the non-linear nature of the relationship between EKS and innovation on an individual level. This represents a fundamental shift in theory on EKS and individual innovation by suggesting a major rethinking of how the two concepts relate, revealing the dark side of EKS in knowledge management if inventors engage in excessive EKS. Likewise, our study’s incorporation of the ABV informs KBV scholarship by highlighting the role of the limited attentional capacity of individuals in firm knowledge management.
From worshipping Tyche to playing with wild cards
Authors: Walter Justine 
Published: February 2024

AbstractIn his Physics, Aristotle acknowledges the role of Tyche, the Greek equivalent of contingency. His home, the Greek peninsula, was, and is today, regularly struck by natural hazards. Ancient records document that they wrought substantial damage to the infrastructure and political integrity of communities. Lacking reliable forecasting systems, for the ancient Greeks any of these hazards was contingent, even though there existed accepted interpretations of what (or who) caused these phenomena. Roughly 2.500 years later, future studies call sudden, unpredictable events like these ‘wild cards’. Occurring with a low probability but a substantial impact, wild cards pose challenges to social, political, and economic stability. Just as natural hazards unexpectedly interrupted and transformed social, political, and economical life in ancient communities, wild cards have the potential to disrupt current and future societies and economies. With the modern world increasingly complex and interconnected, wild cards will increase in frequency, likelihood, and impact. More than ever, local calamities will show global effects. To mitigate these effects and enable a fast recovery, creative approaches are needed. A gaze into how the societies of the distant past successfully coped with the wild cards that hit them, may thus yield inspiration for disaster risk reduction in the Anthropocene.
Payment Practices Transparency and Customer‐Supplier Dynamics
Authors: GREWAL JODY , MOHAN ADITYA , PÉREZ‐CAVAZOS GERARDO 
Published: February 2024

ABSTRACTWe exploit
the introduction of the Payment Practices Disclosure Regulation in the United Kingdom (UK) to examine the effects of mandating disclosure of customer‐supplier payment practices. We find that nondisclosing small and medium‐sized enterprises (SMEs) experience a reduction in their accounts receivable by 8.3%, consistent with an acceleration of their trade credit collections. Further, SMEs exhibit fewer financial constraints after the regulation. We survey managers from large firms and SMEs to understand the underlying mechanisms. The required disclosures raise large firms’ reputational concerns and shift the bargaining power between large firms and SMEs. Additionally, the new disclosures compel executives at large firms to scrutinize their own firms’ payment practices, leading to increased accountability and a stronger focus on timely payment among senior managers.
Research on risk factor filtering and rating of cold chain logistics from the perspective of root‐state risk identification
Authors: Wang Yingchen , Wang Xiangmei , Zhang Yikai , Geng Xiaoxiao 
Published: February 2024

AbstractThe natural attributes of perishable and vulnerable cold chain products make the cold chain have more risks than the general supply chain. The attribute characteristics and internal relations of various risks increase the complexity of risk analysis. The purpose of this paper is to study the horizontal and vertical assessment of various risk factors. The multi‐dimensional risk measurement model is used to integrate the assessment of multiple risk factors of human, machine, environment, and management, and the cold chain risk management is discussed from the perspective of risk factor classification. The root‐state risk identification (RSRI) method was used to identify potential risks. Based on the double standard filtering and multiple criteria, the filtering of irrelevant risks and screening of uncontrollable risks were evaluated, and the triangular fuzzy number method was used to quantitatively evaluate the controllable risk factors. A total of 223 potential risks, 18 important risks, and 6 key risks were identified, followed by inspection and quarantine reports, pesticide residues, improper loading and unloading operations, unqualified centralized environment, unqualified pre‐cooling technology of carriages, and unreasonable storage temperature. According to the analysis results, targeted control measures are proposed to better prevent risks and reduce the probability of cold chain accidents. The traditional risk assessment method can only assess the impact of a single risk factor on the system. This assessment method overcomes this limitation and provides a new perspective for cold chain risk management.Practical ApplicationThis study laid the foundation for further risk safety management of cold chain logistics.
FTO overexpression inhibits the invasion and migration of rheumatoid arthritis fibroblast‐like synoviocytes by suppressing miR‐126‐5p
Authors: Cai Yuxia , Wang Ling , Zheng Yueling 
Published: February 2024

AbstractAimRheumatoid arthritis (RA) inflicts chronic joint inflammation, leading to cartilage damage and potential disability. This study delves into the impact of fat mass and obesity‐associated protein (FTO) on the invasion and migration of fibroblast‐like synoviocytes (FLSs) in RA, aiming to identify a novel target for RA treatment.MethodsRA‐FLSs and control‐FLSs from RA patients and healthy controls were isolated and cultured. An FTO overexpression vector was constructed and transfected into RA‐FLSs, with subsequent measurement of FTO, miR‐126‐5p, and FOXO3 expression levels using quantitative real‐time polymerase chain reaction or western blot assays. The proliferation, invasion, and migration capabilities of RA‐FLSs were assessed. The total m6A modification of cellular mRNA was quantified. The interaction between m6A and DiGeorge syndrome critical region 8 (DGCR8) on pri‐miR‐126‐5p was evaluated using methylated RNA immunoprecipitation. The binding relationship between miR‐126‐5p and FOXO3 3′UTR sequence was verified.ResultsFTO was downregulated in RA‐FLSs. FTO overexpression inhibited the invasion and migration of RA‐FLSs. FTO reduced the m6A modification level of pri‐miR‐126‐5p in RA‐FLSs, inhibiting miR‐126‐5p expression by reducing the binding of DGCR8 to pri‐miR‐126‐5p. miR‐126‐5p targeted and inhibited FOXO3 expression. Overexpression of miR‐126‐5p or FOXO3 knockdown could partially reverse FTO overexpression's inhibitory effect on the invasion and migration of RA‐FLSs.ConclusionFTO overexpression curtailed miR‐126‐5p by diminishing the m6A modification level of pri‐miR‐126‐5p, subsequently enhancing FOXO3 expression and restraining the invasion and migration of RA‐FLSs.
Trends in pain undertreatment among lung cancer patients at the EOL: Analysis of urban city medical insurance data in China
Authors: Zheng Jiani , Huang Yihua , He Junyi , Zhou Huaqiang , Liu Tingting , Huang Jie , Shi Mengting , Zhao Yuanyuan , Fang Wenfeng , Yang Yunpeng , Zhang Li 
Published: February 2024

AbstractBackgroundCancer‐related pain is one of the common priority symptoms in advanced lung cancer patients at the end‐of‐life (EOL). Alleviating pain is undoubtedly a critical component of palliative care in lung cancer. Our study was initiated to examined trends in opioid prescription‐level outcomes as potential indicators of undertreated pain in China.MethodsThis study used data on 1330 patients diagnosed with lung cancer of urban city medical insurance in China who died between 2014 and 2017. Opioid prescription‐level outcomes were determined by annual trends of the proportion of patients filling an opioid prescription, the total dose of opioids filled by decedents, and morphine milligram equivalents per day (MMED) at the EOL (defined as the 60 days before death). We further analyzed monthly changes in the number of opioid prescriptions filled, MMED, and mean daily dose of opioids per prescription (MDDP) of the last 60 days of life by year at death and age, respectively.ResultsA total of 959 patients with exact dates of death were included, with 432 cases (45.06%; 95% CI: 44.36%–45.77%) receiving at least one opioid prescription at the EOL. The declining trends were shown in the proportion of patients filling any opioid prescription, the total dose of opioids filled by decedents and MMED, with an annual decrease of 0.341% (p = 0.01), 104.23 mg (p = 0.011) and 2.84 mg (p = 0.014), respectively. Within the 31–60 days to the 0–30 days of life, the MMED declined 6.08 mg (95% CI: −7.14 to −5.03; p = 0.000351), while the number of opioid prescriptions rose 0.66 (95% CI: 0.160–1.16; p = 0.025). Like the MMED, the MDDP fell 4.11 mg (95% CI: −5.86 to −2.37; p = 0.005) within the last month before death compared to the previous month.ConclusionTerminal lung cancer populations in urban China have experienced reduced access to opioids at the EOL. The clinicians did not prescribe a satisfactory dose of opioids per prescription, while the patients suffered increasing pain in the last 30 days of life. Sufficient opioid analgesic administration should be advocated for lung cancer patients during the EOL period.