bluuebunny/crossref_metadata_2025_split huggingface dataset:
Impact of Machine/Deep Learning on Additive Manufacturing: Publication Trends, Bibliometric Analysis, and Literature Review (2013-2022).
Authors: Chike Onuchukwu Godwin , Chin Yee Jian , Ahmad Norhayati , Ali Wan Fahmin Faiz Wan 
Published: November 2023

Abstract
This paper critically examined the research landscape and the impact of machine/deep learning on additive manufacturing (MDLAM) through publication trends, bibliometric analyses, and literature review. The Elsevier Scopus database was selected to identify and recover publications on MDLAM research published from 2013 to 2022 based on the Prisma approach. The recovered bibliographic data was analyzed using VOSViewer software to examine the co-authorship, keyword, and citation networks on the MDLAM research. Results showed that the publications output (and citations count) increased progressively from 1 (19) to 375 (980) from 2013 to 2022, which exhibits the high TC/TP ratio typically characteristic of highly impactful fields with future growth potentials. Analysis of top performers on the topic revealed that Prahalada K. Rao (US), Pennsylvania State University (US), and National Science Foundation (US) are the most prolific authors, affiliations, and funder of MDLAM research, respectively. Hence, the most active nation on MDLAM research is the United States (US), although China and the United Kingdom have also made significant contributions over the years. Keyword occurrence revealed the existence of several research hotspots with researchers' interests directed at basic research, optimization studies, industrial applications, and novel learning systems. The paper showed that MDLAM is a broad, complex, and impactful research area that will continue to experience scientific growth and technological development, mainly due to the growing demands for accurate computational methods for AM prototypes, processes, and products.
A Combination of CPI-0610 and SAHA Induces Apoptosis through STAT3 and p38 Signalling Pathways in Diffuse Large B-cell Lymphoma Cells
Authors: Xu Linyan , Jiao Jun , Liu Mengdi , Qin Yuanyuan , Zhang Meng , Yan Dongmei , Xu Kailin , Sang Wei 
Published: November 2023

Background::
Although immunotherapies have greatly improved diffuse large B-cell
lymphoma (DLBCL) prognosis, a proportion of patients remain to be relapsed or refractory. Therefore,
the identification of novel therapeutic targets and drugs is urgently required. Inhibition of the
bromodomain and extra-terminal (BET) proteins has been a promising therapeutic strategy for
various haematologic cancers. CPI-0610 is a potent and selective BET inhibitor. The effects of
CPI-0610 in DLBCL cells have not been reported yet.

Aims::
The aim of this study was to assess the effects of CPI-0610 in DLBCL and its underlying
mechanisms.

Methods::
DLBCL cells were treated with CPI-0610, followed by measuring cell viability, cell cycle,
apoptosis, autophagy, and specific cell signaling pathways. Moreover, immunodeficient mice
were engrafted with SUDHL2 cells and then treated with CPI-0610 for analysis of tumor burden.
We also analyzed the synergistic effect of CPI-0610 with histone deacetylase inhibitor suberoylanilide
hydroxamic acid.

Results::
The present study demonstrated that CPI-0610 displayed cell cytotoxicity by arresting
the G1 cell cycle and inducing endogenous and exogenous apoptotic pathways. Additionally,
CPI-0610 decreased BRD4 and c-Myc expressions and affected MAPK, JAK/STAT, and AKT signalling
pathways in human DLBCL cells. An in vivo experiment exhibited that CPI-0610 decreased
the primary tumour growth of the DLBCL xenograft model. Furthermore, the use of
CPI-0610 in combination with suberoylanilide hydroxamic acid exhibited a specific synergistic effect
in inducing apoptosis through the regulation of STAT3 and p38.

Conclusion::
Targeting BET may be an effective therapeutic strategy and potentiated by a combination
with histone deacetylase inhibition in DLBCL.
A Comprehensive Review on Biotransformation, Interaction, and Health
of Gut Microbiota and Bioactive Components
Authors: Zhang Lin , Ma Xiao-Gen 
Published: November 2023

Background::
The relationship between gut microbiota and bioactive components has
become the research focus in the world. We attempted to clarify the relationship between biotransformation
and metabolites of gut microbiota and bioactive components, and explore the
metabolic pathway and mechanism of bioactive ingredients in vivo, which will provide an important
theoretical basis for the clinical research of bioactive ingredients and rationality of drugs,
and also provide an important reference for the development of new drugs with high bioavailability.

Methods::
The related references of this review on microbiota and bioactive components were
collected from both online and offline databases, such as ScienceDirect, PubMed, Elsevier, Willy,
SciFinder, Google Scholar, Web of Science, Baidu Scholar, SciHub, Scopus, and CNKI.

Results::
This review summarized the biotransformation of bioactive components under the action
of gut microbiota, including flavonoids, terpenoids, phenylpropanoids, alkaloids, steroids, and other
compounds. The interaction of bioactive components and gut microbiota is a key link for drug efficacy.
Relevant research is crucial to clarify bioactive components and their mechanisms, which involve
the complex interaction among bioactive components, gut microbiota, and intestinal epithelial
cells. This review also summarized the individualized, precise, and targeted intervention of gut microbiota
in the field of intestinal microorganisms from the aspects of dietary fiber, microecological
agents, fecal microbiota transplantation, and postbiotics. It will provide an important reference for
intestinal microecology in the field of nutrition and health for people.

Conclusion::
To sum up, the importance of human gut microbiota in the research of bioactive
components metabolism and transformation has attracted the attention of scholars all over the
world. It is believed that with the deepening of research, human gut microbiota will be more
widely used in the pharmacodynamic basis, drug toxicity relationship, new drug discovery, drug
absorption mechanism, and drug transport mechanism in the future.
Acceptability, Effectiveness, and Roles of mHealth Applications in Supporting Cancer Pain Self-Management: Integrative Review (Preprint)
Authors: Wu Weizi , Graziano Teresa , Salner Andrew , Chen Ming-Hui , Judge Michelle P , Cong Xiaomei , Xu Wanli 
Published: November 2023

BACKGROUND

Cancer pain remains highly prevalent and persistent throughout survivorship, and it is crucial to investigate the potential of leveraging the advanced features of mobile health (mHealth) apps to empower individuals to self-manage their pain.

OBJECTIVE

This review aims to comprehensively understand the acceptability, users’ experiences, and effectiveness of mHealth apps in supporting cancer pain self-management.

METHODS

We conducted an integrative review following Souza and Whittemore and Knafl’s 6 review processes. Literature was searched in PubMed, Scopus, CINAHL Plus with Full Text, PsycINFO, and Embase, from 2013 to 2023. Keywords including “cancer patients,” “pain,” “self-management,” “mHealth applications,” and relevant synonyms were used in the search. The Johns Hopkins research evidence appraisal tool was used to evaluate the quality of eligible studies. A narrative synthesis was conducted to analyze the extracted data.

RESULTS

A total of 20 studies were included, with the overall quality rated as high (n=15) to good (n=5). Using mHealth apps to monitor and manage pain was acceptable for most patients with cancer. The internal consistency of the mHealth in measuring pain was 0.96. The reported daily assessment or engagement rate ranged from 61.9% to 76.8%. All mHealth apps were designed for multimodal interventions. Participants generally had positive experiences using pain apps, rating them as enjoyable and user-friendly. In addition, 6 studies reported significant improvements in health outcomes, including enhancement in pain remission (severity and intensity), medication adherence, and a reduced frequency of breakthrough pain. The most frequently highlighted roles of mHealth apps included pain monitoring, tracking, reminders, education facilitation, and support coordination.

CONCLUSIONS

mHealth apps are effective and acceptable in supporting pain self-management. They offer a promising multi-model approach for patients to monitor, track, and manage their pain. These findings provide evidence-based insights for leveraging mHealth apps to support cancer pain self-management. More high-quality studies are needed to examine the effectiveness of digital technology–based interventions for cancer pain self-management and to identify the facilitators and barriers to their implementation in real-world practice.
PENGARUH PROMOSI, HARGA, KUALITAS PRODUK DAN GAYA HIDUP TERHADAP KEPUTUSAN PEMBELIAN SKINCARE OLEH PRIA DI KOTA LANGSA
Authors: Rahman Maulana , Meutia Rahmi , Eka Varika 
Published: November 2023

Penelitian ini bertujuan untuk mengetahui pengaruh Promosi, Harga, Kualitas Produk, dan Gaya Hidup terhadap Keputusan Pembelian Skincare oleh pria di Kota Langsa. Populasi dalam penelitian ini adalah masyarakat umum pria di Kota Langsa yang sudah menggunakan skincare. Teknik penentuan sampel pada penelitian ini menggunakan teknik non probability sampling dengan metode purposive sampling dengan kriteria sudah menggunakan produk skincare pria yang berusia antara 17 – 35 tahun. Penelitian ini menggunakan metode analisis dasar menggunakan regresi linier berganda, uji t, uji F dan uji koefisien determinasi (Adjusted R2). Hasil uji validitas pada kuesioner variable promosi, harga, kualitas produk dan gaya hidup kesemuanya dinyatakan valid. Hasil reabilitas dapat disimpulkan bahwa seluruh variabel yang digunakan dalam penelitian ini dinyatakan reliabel. Hasil penelitian ini menunjukkan bahwa hasil uji t menunjukkan bahwa variabel promosi (X1), harga (X2) , kualitas produk (X3), dan gaya hidup (X4) secara parsial berpengaruh signifikan terhadap keputusan pembelian skincare oleh pria di Kota Langsa. Hasil uji F menunjukkan bahwa promosi (X1), harga (X2), kualitas produk (X3), dan gaya hidup (X4) secara simultan berpengaruh signifikan terhadap keputusan pembelian skincare oleh pria di Kota Langsa.
PENGARUH PENGAWASAN, LINGKUNGAN KERJA, DAN KOMITMEN ORGANISASI TERHADAP KINERJA PEGAWAI DI KANTOR CAMAT LANGSA LAMA
Authors: Sigalingging Lerdi Yanti , Zati Muhammad Rizqi , Rosalina Dhian 
Published: November 2023

This study aims to determine the influence of supervision, work environment, and organizational commitment on employee performance at the Langsa Lama District Office. This research uses quantitative methods. The analytical method used is the multiple linear regression method. The sample in this study was 52 people, using a saturated sampling method, where the entire population would be sampled. In this research, data collection uses interview and questionnaire techniques, where the questionnaire has been tested for validity and reliability. The results of the t test on the supervision variable have an insignificant influence on employee performance at the Langsa Lama District Head Office, the work environment variable has a positive and significant influence on employee performance at the Langsa Lama District Head Office, and the organizational commitment variable has a positive and significant influence on employee performance at the Langsa Lama Subdistrict Office. The results of the F test simultaneously have a significant influence on employee performance at the Langsa Lama District Head Office. The conclusion of this research is that the low level of supervision that occurs at the Langsa Lama Subdistrict Office will result in performance decreasing, thereby causing the goals of the agency to not be achieved, therefore it is very necessary for leaders to be firm and pay attention to each employee's performance, and so Also, the working environment at the Langsa Lama District Head's Office is very good, where the conditions in the agency are all conducive and comfortable, so this is able to increase employees to obtain even better performance, and the organizational commitment that every employee of the Office has. The Langsa Lama sub-district head is in the high category, this can be seen from the contribution and readiness of the employees to carry out their work which is always completed well and the level of employee desire to always stay with the agency is very large. Keywords: Supervision, Work Environment, Organizational Commitment, Employee Performance
The “Giant Role Model”: the “Serbian” Petőfi
Authors: Hász-Fehér Katalin 
Published: November 2023

Abstract
The reception of Sándor Petőfi’s poems and the critical discourse on them in German by bilingual German poets and publicists in Hungary began during the poet’s lifetime and ran parallel to the development of his career. In the same period, however, from the mid-1840s, a very intense interest in his person and his poetry, which was even deeper and more diverse than in German, was awakened in southern Slavic, especially Serbian, literature. This paper explores the possible reasons for his integration in Serbian poetry and public poetry. Among the most important factors is the fact that in the 18th and 19th centuries, strong centres of Serbian culture developed in Hungary, including Buda, and that in the northern part of present-day Serbia, in Vojvodina, the population had for centuries been of mixed nationality, including Serbs, Hungarians and Germans. As a result, a large part of the Serbian intelligentsia spoke Hungarian, and many of the Hungarians in Vojvodina had spoken Serbian since the last century, so they could read each other’s literature in the original. Petőfi’s poetry, like much of 19th century Hungarian literature, was translated by renowned authors, sometimes of European quality, and his poetry was an inspiration for Serbian Romanticism in terms of form, theme and poetics (Jovan Jovanović Zmaj, Đura Jakšić). Finally, it is worth mentioning the historical circumstances, the fact that, although the two peoples were on opposite political sides in the Hungarian War of Independence of 1848 and several times later, Petőfi’s figure transcended political differences and his reception remained unbroken even in the most difficult periods. The belief that Petőfi, who originally went by the name Petrovics, was of Serbian origin – a belief that is difficult to verify biographically – and which dates back to Petőfi’s own time, has contributed to this. The layers and trends in the history of Petőfi’s reception in Serbia also shed light on the mechanisms of intellectual relations in the common cultural space of the peoples of Central and Eastern Europe and the Western Balkans.
Hidden in snow: Selected aspects of chemical composition of an urban snow cover (Kielce, SE Poland)
Authors: Szwed Mirosław , Kozłowski Rafał , Śliwa Zuzanna , Zeliaś Aleksandra , Przybylska Joanna , Ludew Marta 
Published: November 2023

Abstract
Snow cover is a valuable source of information about air quality. It enables detection of dust and other air pollutants which have been accumulated throughout the period since the snow cover was formed. Research conducted in Kielce confirms multidirectional human pressure from local and regional emission sources. Combustion of fuels resulted in lower pH and increased EC, SO4 and NO3 concentrations in the southern and northern parts of the city. Elevated concentrations of Cl and Na indicate the effect of transportation and winter road maintenance. Apart from local emitters, air quality in Kielce is affected by the regional sources, including the nearby center of the lime and cement industries. Climate change is reflected in the number of days with snow and thickness of snow cover, declining since the 1990s.
STRATEGIC ANALYSIS OF PT. KMDS, TBK. (INDONESIA’S MONIN SYRUPS DISTRIBUTOR & IMPORTER)
Authors: Lukman Steven , Maupa Haris 
Published: November 2023

This study aim to formulate strategy for PT. KMDS, Tbk. which will be started with identify the posision of the company in the market in order to know the competitive advanatge in the market. After established for more than 20 years PT. KMDS, Tbk. should improve accordingly with the growth of the market. Qualitative method will be used with purposive sampling & total of 16 samples will consist at least working in managerial position & working in sales department. The samples will be covering the scope of Java & Bali island as it was the biggest contributor of national sales for company. The instrument used in this research will be questionnaires formulated from the internal & external factor analysis strategy. The data gathered then will be processed using Strategic Position And Action Evaluation (SPACE) matrix combined with the SWOT matrix thus called SWOT quadrant analysis.The result shown that according to the samples respond, PT. KMDS, Tbk. does have big score both in the internal & external factor. Detailed explanation shown that company stregth overpower the weakness & opportunity also overpower the threat. Thus, it is concluded that the company posisition is at the 1st Quadrant which support for the aggressive strategy
THE IMPACT OF COVID-19, TRADING VOLUME ACTIVITY AND MARKET CAPITALIZATION ON STOCK RETURN OF LQ-45 COMPANIES
Authors: Chandra Nadya Aurelia , Suhendah Rousilita 
Published: November 2023

The objective of this research is to analyze the impact of daily growth of Covid-19 positive case, Trading Volume Activity (TVA), and market capitalization on LQ-45 companies’ stock return in IDX on the year 2020. This research uses multiple regression models on sample size of 41 companies using non-probability sampling method. This research’s analysis approach is as follow: statistical descriptive analysis, t-test, F-test and Coefficient of Determination test. Data processing in this research is done by Microsoft Excel and Eviews 12. This study uses Signalling Theory, Black Swan Theory and Efficient Market Hypothesis Theory as grand theories to explain the relationship between variables used in this study and resulted that the daily growth of Covid-19 positive case and TVA partially have a positive effect on stock return, while market capitalization has a negative effect on stock return. This research is designed to be beneficial for investors as a basis for making investment decisions, as well as assisting company management regarding the management of company performance to increase stock prices.
Formulation and Acute Toxicity, Anti-Inflammatory, Analgesic Effects of Hard Capsules of Herba Siegesbeckiae Orientalis Dry Extract in Experimental Animals
Authors: Thi Van Anh Tran , Quoc Tuan Pham , Van Khanh Nguyen , Viet Hung Dao , Thanh Hai Nguyen , Thi Xuan Thinh Ngo , Thanh Hoa Ha , Kim Thu Dang , Thi Thuy Linh Nguyen , Thu Quynh Nguyen 
Published: November 2023

This study aimed to investigate the acute toxicity, analgesic and anti-inflammatory effects of hard capsules containing dry extract from Siegesbeckia orientalis L. (CKHT) in animal models. Hard capsules were prepared using the volumetric method, with Avicel PH 102 as the diluent excipient and magnesium carbonate as the adsorbent excipient. The acute toxicity of CKHT was assessed on white mice at a dose of 2,400 mg/kg body weight. The anti-inflammatory effect was evaluated using a carrageenan-induced paw edema model in rats, while the analgesic effect was tested using an acetic acid-induced writhing model in mice. The results showed that CKHT administered at the doses of 102.2 mg/kg/day, 204.4 mg/kg/day, and 408.8 mg/kg/day had significant anti-inflammatory effect on the carrageenan-induced rat paw edema model by reducing the paw volume and increasing the percentage of edema inhibition compared to the untreated group (p < 0.001). The dose of CKHT 408.8 mg/kg/day showed anti-inflammatory effects that similar to aspirin at the dose level of 200 mg/kg/day (p > 0.05). In the analgesic study, mice treated with CKHT at the doses of 188.7 mg/kg/day, 377.4 mg/kg/day, and 754.8 mg/kg/day had significant reduction in acetic acid-induced writhing within 30 minutes compared to the untreated group (p < 0.001). Furthermore, CKHT did not show acute toxicity (no LD50) at the dose of 2,400 mg/kg body weight. These results suggested that CKHT exhibited acute analgesic and anti-inflammatory effects in animal models.
Keywords: Dried extract from Siegesbeckia orientalis L.; capsules; anti-inflammatory; analgesic.
Characteristics of Exacerbation and Antibiotic Usage in Treatment for Exacerbation of COPD Patients in National Lung Hospital (2022-2023)
Authors: Huyen Hoang Thu , Cuong Nguyen Kim , Thi Luyen Le 
Published: November 2023

Abstract: Exacerbations of COPD are important events in the progression of the disease, being the leading cause of hospitalization and mortality. Bacterial respiratory infections are one of the main causes of exacerbations. This retrospective study was described characteristics of exacerbation and antibiotic use in COPD exacerbation patients hospitalized at the National Lung Hospital. This study included 200 hospitalized patients from January2022 to June 2023. Many patients in the study sample were male (90%), 76% of patients had two or more exacerbations per year. The most isolated bacteria are Haemophilus influenzae, Pseudomonas aeruginosa, Acinetobacter baumannii. There were 77,5% pneumonia patients had Drug Susceptibility Tests (DST), and 54,7% of patients had antibiotic regimens consistent with the DST. The results of this study provide a reliable basis for selecting and improving the effectiveness of antibiotic use in the treatment of COPD exacerbations, improving outcomes and survival prognosis for patients.
Keywords: COPD, exacerbation, bacteria, antibiotics.