bluuebunny/crossref_metadata_2025_split huggingface dataset:
Intra-tumoral molecular heterogeneity of grade 3 astrocytomas and oligodendrogliomas and its significance in disease prognosis
Authors: Nikitin P. V. , Belyaev A. Yu. , Musina G. R. , Kobyakov G. L. , Pronin I. N. , Usachev D. Yu. 
Published: December 2023

Introduction. Malignant brain tumors, such as anaplastic astrocytomas and anaplastic oligodendrogliomas grade 3, are characterized by high aggressiveness and pose a serious clinical problem. This study focuses on assessing intratumoral heterogeneity in anaplastic astrocytomas and anaplastic oligodendrogliomas and its impact on disease prognosis.Aim. To study characteristics of intratumoral heterogeneity, in particular such morphological criteria as necrosis, vascular proliferation, mitoses, and mutations in the most significant for glioma progression genes in the groups of grade III astrocytomas and oligodendrogliomas, as well as analysis of prognostic significance of these parameters.Materials and methods. The study included 389 patients with IDH-mutant astrocytomas and 200 patients with oligodendrogliomas. The mean Ki-67 labeling index of astrocytomas was 12.78 %, while that of oligodendrogliomas was 8.54 %.Results. The presence of vascular proliferation, necrosis, of more than 20 % of the area of the specimen occupied by sarcomatous-like areas and the number of mitoses significantly affected not only disease-free survival but also overall survival of patients. In the clinical setting, mutations in the TERT promoter gene, amplification and mutation of the EGFR gene, deletion of the CDKN2A gene, and TP53 gene had a significant negative impact on recurrence-free and overall survival.Conclusion. The results of single-cell RNA sequencing showed additional factors, including sarcomatous-like areas, as well as TERT, EGFR, CDKN2A and TP53 mutations, in the progression of the tumors under consideration and in ensuring an increase in their malignant potential.
Pembelajaran Blending Asynchronous-Synchronous Learning Berbasis Relevan terhadap Hasil Belajar Koqnitif Peserta Didik Sekolah Dasar pada Masa Pandemi
Authors: Susanti Lidia , Estherina Rira 
Published: December 2023

Abstrak: Penelitian strategi pembelajaran berbasis relevan dengan metode blending asynchronous dan synchronous terhadap hasil belajar kognitif peserta didik kelas 5 Sekolah Dasar bertujuan untuk mengetahui dampak pembelajaran online terhadap kognitif peserta didik. Dalam riset ini kelas kontrol dan kelas eksperimen mendapat media pembelajaran yang sama, asynchronous learning menggunakan aplikasi Google Classrom sehingga peserta didik dapat mengirim materi, dapat mengumpulkan tugas dan dapat berkomunikasi secara tidak langsung dengan guru. Sedangkan synchronous learning menggunakan aplikasi zoom, dimana peserta didik dapat berinteraksi dan berkomuniasi dengan guru dan teman secara langsung. Kelas control tidak menggunakan pembelajaran berbasis relevan berjumlah 24 anak dan kelas eksperimen, menggunakan pembelajaran berbasis relevan berjumlah 44 anak. Hasil penelitian diperoleh rata- rata pretest kelas control sebesar 54,38 serta kelas eksperimen 55,94 sebaliknya hasil rata- rata posttest kelas control sebesar 63,54 serta kelas eksperimen sebesar 83,50. Hasil ini menampilkan perbedaan yang signifikan, setelah itu dilanjutkan dengan uji statistic sampai pada tahap uji korelasi dan memperoleh hasil yang signifikan sebesar 0.743 serta sig 0.000. Kontribusi pembelajaran berbasis relevan sebesar 55.1% terhadap hasil belajar kognitif siswa. Abstract: Research on blending relevance based asynchronous and synchronous learning across the cognitive result of 5th grade elementary school students. The aim is to determine the impact of online learning on cognitive students. In this research, the control class and the experimental class received the same learning media, asynchronous learning using the Google Classroom application so that students could send materials, collect assignments and communicate indirectly with the teacher. Meanwhile, synchronous learning uses a zoom application, where students can interact and communicate with teachers and friends directly. The control class did not use relevant-based learning with a total of 24 children and the experimental class, which used relevant-based learning, amounted to 44 children. The results showed that the average pretest for the control class was 54.38 and the experimental class was 55.94. On the other hand, the average posttest for the control class was 63.54 and the experimental class was 83.50. These results show a significant difference, then continued with statistical tests to the correlation test stage and obtained significant results of 0.743 and 0.000 sig. The contribution of relevant-based learning is 55.1% to students' cognitive learning outcomes.
Pola Soal Soal HOTS Kitab Al-‘Arabiyyah Bayna Yadaik Jilid 1-3
Authors: Tamam Fityan Fikrut , Ainin Moh. 
Published: December 2023

Kitab Al-‘Arabiyyah Bayna Yadaik (ABY) digunakan pada banyak kampus termasuk di prodi S1 Pendidikan Bahasa Arab, Jurusan Sastra Arab, Universitas Negeri Malang. Penelitian ini bertujuan mendeskripsikan kategorisasi tingkatan soal HOTS ABY Jilid 1-3, relevansi muatan soal-soal HOTS terhadap kemahiran berbahasa, dan komposisi jumlah soal HOTS terhadap kemahiran berbahasa. Penelitian ini menggunakan jenis pendekatan deskriptif kualitatif. Hasil dari penelitian ini meliputi tiga hal yaitu: (1) Kategorisasi tingkatan soal HOTS yang terdiri atas soal analisis, soal evaluasi, dan soal kreasi yang memiliki karakteristik pola tertentu, (2) Relevansi muatan soal-soal HOTS terhadap kemahiran berbahasa yang menunjukkan tersebarnya soal-soal HOTS secara merata pada semua aspek kemahiran berbahasa, dan (3) Komposisi jumlah soal HOTS terhadap kemahiran berbahasa yang menunjukan ABY 1 dominan soal HOTS keterampilan menyimak, ABY 2 dominan soal HOTS keterampilan menulis, dan ABY 3 dominan soal HOTS keterampilan membaca.
Kata Kunci: bahasa Arab; ABY; HOTS
The Question Pattern of HOTS Questions in the Al-'Arabiyyah Bayna Yadaik Book Volumes 1-3
The Al-'Arabiyyah Bayna Yadaik (ABY) Book is used on many campuses, including the Arabic Language Education Bachelor's Degree Study Program, Department of Arabic Literature, State University of Malang. This study aims to describe the level categorization of ABY's HOTS questions Volumes 1-3, the relevance of the content of HOTS questions to language proficiency, and the composition of the number of HOTS questions on language proficiency. This research uses a qualitative descriptive approach. The results of this study consist three things: (1) Categorization of levels of HOTS questions consisting of analysis questions, evaluation questions, and creation questions that have characteristics of certain patterns, (2) the relevance of the content of HOTS questions to language proficiency which shows that HOTS questions are evenly distributed in all aspects of language proficiency, and (3) The composition of the number of HOTS questions to language proficiency shows that ABY chapter 1 is dominant in HOTS listening skill questions, ABY chapter 2 is dominant in HOTS writing skill questions, and ABY chapter 3 is dominant in HOTS reading skill questions.
Keywords: Arabic language; ABY; HOTS
Determination of Fungal and Bacterial Disease Agents on Minor Vegetable of Different Brassica Species Grown in Hatay Province
Authors: SOYLU Soner , KARA Merve , UYSAL Aysun , GÜMÜŞ Yusuf , SOYLU Emine Mine , KURT Şener , ÜREMİŞ İlhan , SERTKAYA Erdal 
Published: December 2023

The Brassicaceae family, commonly known as the Cruciferae or mustard family, encompasses plant species of global economic significance, including oilseed crops, vegetables, as well as condiment purposes. Hatay Province is among the significant regions in Turkey where Brassicaceae family vegetables are cultivated. This study aimed to identify the causative agents of diseases affecting minor Brassica vegetables including cabbage (red and white varieties), broccoli, cauliflower, garden cress, rocket, and radish in the districts of Hatay Province where vegetable cultivation took place during the 2020-2021 growing seasons. Isolations from suspicious cabbage, broccoli, cauliflower, and radish plants exhibiting disease symptoms in the surveyed areas revealed the presence of various fungal disease agents, including Rhizoctonia solani, Sclerotinia sclerotiorum, Fusarium solani, Fusarium oxysporum, Fusarium equiseti, Alternaria alternata, Botrytis cinerea, and Stemphylum sp. Furthermore, obligate parasitic oomycete pathogens such as Albugo lepidii, Albugo candida, and Perofascia lepidii were detected with varying prevalence and incidence rates on leaves and stems of water cress, rocket, and radish plants.
In addition to fungal pathogens, primary bacterial pathogens, including Xanthomonas campestris pv. campestris, Pectobacterium carotovorum subsp. carotovorum, Pectobacterium parmentieri, Pseudomonas corrugata, and Pseudomonas cichorii, were identified through morphological, biochemical, pathogenicity tests, and MALDI-TOF analyses. Pantoea agglomerans, Pseudomonas marginalis, Pseudomonas fluorescens, Enterobacter cloacae, and Bacillus pumilus were also identified as opportunistic soft rot bacterial pathogens.
To the best of our knowledge, this is the first report of F. solani, F. oxysporum, F. equiseti, A. alternata, B. cinerea, Stemphylum sp., P. parmentieri, P. corrugata, and P. cichorii as primary bacterial pathogens, P. agglomerans, P. marginalis, P. fluorescens, E. cloacae, and B. pumilus as opportunistic secondary soft rot bacterial disease agent affecting different minor Brassica vegetables, such as cabbage (red and white varieties), broccoli, cauliflower, radish, rocket, and garden cress, grown in Turkey.
Pengaruh Inflasi, Kurs, dan PDB terhadap Profitabilitas Bank Umum Syariah di Indonesia dengan Pembiayaan Sebagai Variabel Intervening
Authors: Selayan Asyaadatun Nazila , Yafiz Muhammad , Daulay Aqwa Naser 
Published: December 2023

Penelitian ini bertujuan untuk mengetahui pengaruh variabel Inflasi, Kurs, dan PDB terhadap Profitabilitas Bank Umum Syariah dengan pembiayaaan sebagai lembaga intervening yang diproyeksikan dengan Retrun On Asset (ROA). Penelitian ini dilakukan dengan menggunakan metode kuantitatif dengan data sekunder yang điperoleh dari website resmi Statistik Perbankan Syariah, Ojk , BI, dan BPS. Data yang digunakan merupakan data runtut waktu dari Maret 2015 sampai dengan Desember 2022. Analisis data menggunakan uji asumsi klasik yang terdiri dari : (a) Uji Normalitas; (b) Uji Multikolonieritas; (c) Uji Linieritas; (d) Uji Autokorelasi; (e) Uji Heteroskedastisitas. Selanjutnya digunakan uji statistik yang terdiri dari: (a) Uji t; (b) Uji F; (c) Uji Koefisien Determinasi; dan (d) uji jalur. Berdasarkan hasil penelitian ini diperoleh kesimpulan sebagai berikut : Hasil penelitian menunjukkan bahwa Inflasi dan Kurs berpengaruh tidak signifikan terhadap pembiayaan, PDB berpengaruh positif dan signifikan terhadap pembiayaan. Inflasi, Kurs, dan Pembiayaan berpengaruh tidak signifikan terhadap Profitabilitas, PDB berpengaruh positif signifikan terhadap Profitabilitas. Namun, Pembiayaan tidak dapat memediasi pengaruh antara variabel Inflasi, Kurs, dan PDB terhadap Profitabilitas.
Avaliação da pesquisa científica no âmbito das políticas nacionais de ciência aberta
Authors: Trinca Tatiane Pacanaro , Albagli Sarita 
Published: December 2023

Introdução: A ciência aberta recebe crescente destaque nas agendas das políticas científicas internacionais, convergindo-se para o entendimento de que sua consolidação como prática acadêmica depende da reformulação do atual sistema de avaliação da pesquisa. Objetivo: O estudo busca identificar e analisar em que medida e de que modo políticas de ciência aberta incorporam e abordam a avaliação da pesquisa. Metodologia: Realizou-se pesquisa bibliográfica e documental, a partir da seleção de políticas públicas de ciência aberta de cinco países — Finlândia, Eslovênia, Holanda, França e Colômbia. Resultados: Observou-se que os países com políticas consideradas mais abrangentes reconhecem a necessidade de reformulação dos mecanismos de reconhecimento e recompensa para contemplar componentes da ciência aberta. Apenas a Política francesa apresenta indicativos mais concretos de mudanças. A Política Nacional de Ciência Abierta 2022-2031, da Colômbia, indica metas e prazos de execução para a adoção da ciência aberta em processos de avaliação da pesquisa e de classificação de grupos e pesquisadores, a partir da proposta de revisão de seus sistemas de acreditação de programas e instituições. Os planos da Holanda, Eslovênia e Finlândia também preveem mudanças após realizarem exames dos atuais instrumentos e critérios que adotam, seja averiguando a viabilidade do uso de indicadores altmétricos (Holanda), seja incluindo novos métodos (Eslovênia) ou considerando novos e variáveis formatos de publicação (Finlândia). Conclusão: Observa-se certa limitação em passar de uma política discursiva de apoio à ciência aberta para uma política com dispositivos que impliquem em mudanças concretas nos critérios e procedimentos usados nas avaliações.
Pengenalan Pembelajaran Bahasa Inggris Melalui Metode Permainan “Cat And Mouse” di Desa Sangal Kalimantan Tengah
Authors: Debora Debora , Syeba Sulamit 
Published: December 2023

Kegiatan Pengabdian kepada Masyarakat (PkM) ini bertujuan untuk memperkenalkan kepada sekolah tentang salah satu strategi pembelajaran bahasa Inggris dengan permainan, khususnya di Sekolah Dasar Negeri di Desa Sangal Provinsi Kalimantan Tengah yang diselenggarakan pada tanggal 11 Desember 2019. Salah satu teknik yang dapat dilakukan dalam suatu pembelajaran Bahasa Inggris, yaitu pembelajaran Bahasa Inggris melalui permainan. Dengan demikian akan menumbuhkan motivasi bagi siswa untuk belajar Bahasa Inggris yang dapat dilakukan oleh sekolah sebagai mata pelajaran muatan lokal. Metode yang digunakan adalah dengan praktik langsung kepada anak didik, sehingga menjadi suatu pengalaman pembelajaran bagi siswa. Siswa mempraktikkan langsung pembelajaran melalui permainan ini pembelajaran tersebut akan melekat dan menjadi pengalamannya. Tanggapan dari siswa melalui wawancara untuk memperoleh tanggapan tentang pembelajaran yang dilakukan diperoleh tanggapan yang positif dan dapat meningkatkan motivasi untuk belajar Bahasa Inggris lebih lanjut. Hasil tes secara lisan diperoleh 80% siswa dapat menjawab dengan benar. Hal ini menunjukkan bahwa materi yang diberikan dalam bentuk permainan akan mudah diingat oleh siswa. Pembelajaran menggunakan permainan adalah salah satu alternatif metode pembelajaran yang dapat meningkatkan motivasi belajar siswa dalam mempelajari Bahasa Inggris, sehingga metode pembelajaran ini dapat dilakukan oleh guru menjadi suatu pilihan dalam pelajaran Bahasa Inggris. This Community Service activity aims to introduce to schools one of the English learning strategies with games, especially in public elementary schools in Sangal Village, Central Kalimantan Province, held on December 11, 2019. One of the techniques that can be done in English learning, namely English learning through games. Thus, it will motivate students to learn English, which schools can use as local content subjects. The method is by direct practice to students so that it becomes a learning experience for students. Learners practice learning directly through this game; the learning will stick and become their experience. The response from students through interviews to obtain feedback on the learning was positive and can increase motivation to learn English further. Oral test results obtained 80% of students can answer correctly. This shows that students will easily remember the material through games. Learning using games is one of the alternative learning methods that can increase students' learning motivation in learning English, so this learning method can be carried out by teachers as an option in English lessons.
Pelatihan Penggunaan Aplikasi Accurate Sebagai Upaya Peningkatan Kompetensi Mahasiswa PLP Program Studi Pendidikan Akuntansi
Authors: Saputra Irwan Adimas Ganda , Wulandari Wida , Hestiningrum Putri 
Published: December 2023

Aplikasi accurate telah digunakan dari 100.000 usaha kecil dan perusahaan besar untuk menyusun laporan keuangan. Sudah banyak sekolah kejuruan yang memasukkan aplikasi accurate ini sebagai materi pokok dalam pembelajaran akuntansi. Perguruan tinggi harus dapat menyesuaikan agar mahasiswa yang akan melaksanakan PLP di sekolah kejuruan bidang akuntansi memiliki bekal yang cukup. Kegiatan ini diikuti oleh 32 orang yang bertujuan untuk meningkatkan pemahaman mahasiswa PLP terhadap penggunaan aplikasi accurate. Kegiatan ini berbentuk pelatihan dengan menggunakan metode ceramah, diskusi dan praktik digunakan dalam pelaksanaan kegiatan pelatihan ini. Pelatihan dilaksanakan selama 2 hari yaitu tanggal 5 dan 12 Agustus 2022. Dari hasil evaluasi diketahui bahwa secara keseluruhan tingkat pemahaman peserta pelatihan mencapai 98.35%. Hal ini menunjukkan hasil yang sangat baik. Selain itu, kegiatan ini juga menghasilkan sebuah buku yang dapat dijadikan sebagai bahan ajar. Kegiatan ini memberikan implikasi bahwa dengan adanya pelatihan ini dapat memberikan pengetahuan baru kepada mahasiswa sehingga mahasiswa mendapatkan bekal untuk menjalankan PLP nantinya.The accurate application has been used by 100,000 small businesses and large companies to prepare financial statements. Many vocational schools have included this accurate application as a subject matter in learning to account. Universities must be able to adjust so that students who will carry out PLP in vocational schools in accounting have sufficient provisions. This activity was attended by 32 people who aimed to improve PLP students' understanding of using accurate applications. This activity is in the form of training using lectures, discussion and practice methods used in this training activity. The training was held for 2 days on 5 and 12 August 2022. The evaluation results show that the overall level of understanding of the trainees reached 98.35%. This shows very good results. In addition, this activity also produced a book that can be used as teaching material. This activity implies that this training can provide new knowledge to students so that students get provisions to carry out PLP later.
KKM Tematik 1 Untirta: Kegiatan Sosial Donor Darah di Desa Tirtayasa Kabupaten Serang Banten
Authors: Wigati Restu , Fathonah Woelandari , Nasheh Muhammad Yusril , Sulthonah Nufus 
Published: December 2023

Darah merupakan komponen yang sangat penting sebagai alat distribusi, transportasi dan sirkulasi yang menjadi bagian di dalam tubuh manusia. Dibutuhkan sekitar 5,5 juta kantong darah setiap tahun sedangkan kebutuhan darah nasional baru terpenuhi 85 persen. Tujuan kegiatan pengabdian masyarakat yang dilakukan oleh mahasiswa KKM Untirta melalui penyuluhan dan pelaksanaan donor darah memberikan edukasi sekaligus kesadaran masyarakat untuk melakukan donor darah. Pentingnya donor darah secara rutin dapat membantu UTD-PMI Kabupaten Serang menjalankan tugasnya sebagai penyedia darah bagi rumah sakit yang kekurangan stok darah sehingga mampu dengan cepat menangani pasien yang membutuhkan darah. Metode yang digunakan yaitu melalui kegiatan penyuluhan dan pelaksanaan donor darah yang dilakukan oleh Unit Transfusi Darah Kabupaten Serang. Hasil kegiatan sosial penyuluhan dan donor darah dilaksanakan tanggal 25 Januari 2023 dihadiri 35 peserta, 17 orang bersedia sebagai pendonor yang berasal dari masyarakat Desa Tirtayasa Kabupaten Serang dan mahasiswa KKM kelompok 101 Untirta. Sebanyak 29,41 persen dari pendonor berhasil diambil darahnya. Beberapa faktor yang dapat menyebabkan usaha transfusi darah menjadi gagal diantaranya kurangnya tensi dan hemoglobin dalam tubuh. Blood is an essential component of distribution, transportation, and circulation which is part of the human body. About 5.5 million blood bags are needed yearly, while the national blood need is only 85 percent met. The purpose of community service activities by KKM Untirta students through counseling and implementation of blood donors is to provide education and public awareness to donate blood. The importance of routine blood donors can help UTD-PMI Serang Regency carry out its duties as a blood provider for hospitals that lack blood stock so that they can quickly treat patients who need blood. The method used is through outreach activities, and the implementation of blood donors carried out by the Serang District Blood Transfusion Unit. The results of social counseling and blood donation activities were carried out on January 25, 2023, attended by 35 participants, 17 people willing to become donors who came from the Tirtayasa Village community, Serang Regency, and KKM students from the 101 Untirta group. As many as 29.41 percent of the donors had their blood drawn. Several factors can cause blood transfusion attempts to fail, including a lack of blood pressure and hemoglobin in the body.
Nuggettori: Pemanfaatan Sawi Sebagai Produk Olahan Kreatif “Nugget Sayur”
Authors: Rohmah Latifatu , Fitriyani Yeny , Wafirah Milna , Pudail Mohammad 
Published: December 2023

Potensi komoditi Sayuran sawi ijo (chaisim) di Dusun Tlogo, Desa Sutopati, Kecamatan Kajoran tidak dibarengi dengan harga jual yang memadai, sehingga perlu adanya peningkatan kapasitas masyarakat melalui kreatifitas olahan nugget sawi ijo. Tujuan program kegiatan pendampingan yaitu meningkatkan kapasitas masyarakat melalui pelatihan nugget sawi ijo, adapun pendampingan dilakukan pada bulan Agustus-September 2022. Sasaran pendampingan adalah Ibu-ibu yang tergabung dalam Kelompok Wanita Tani Dusun Tlogo, dengan pertimbangan bahwa ibu-ibu adalah pemegang keuangan dan penyedia makanan keluarga sehingga harus paham bagaimana mengelola keuangan keluarga dengan cara mengolah makanan yang murah dan sehat. Metode PAR (Participatory action research) dianggap sesuai dengan pola pendampingan yang dilakukan, dimana peneliti dan masyarakat berkolaborasi untuk memaham masalah sosial dan mengambil tindakan untuk membawa perubahan sosial. Hasil pendampingan adalah masyarakat khususnya Ibu-ibu Dusun Tlogo memiliki kemampuan dalam mengelola sawi ijo menjadi nugget dan bisa menjadi peluang usaha untuk meningkatkan produktifitas dan perekonomian masyarakat. Kesimpulan dari pendampingan dalam meningkatkan kapasitas Ibu-ibu melalui pelatihan nugget sawi ijo sangat diperlukan dalam mewujudkan kemandirian ekonomi Ibu-ibu di Dusun Tlogo.Potential for vegetable mustard greens (chai sim), commodities in Tlogo Hamlet, Sutopati Village, Kajoran, do not companied by an adequate selling price, so it is necessary to increase community capacity through the creative processing of green mustard nuggets. The objective of the mentoring activity program is to increase community capacity through green mustard greens nugget training, while the assistance is held from August-September 2022. The target of the assistance is mothers who are members of the Tlogo Dusun Women Farmer Group, in line with the consideration that mothers are financial holders and providers of family food, and they must understand how to manage family finances by preparing cheap and healthy food. The PAR method (Participatory action research) is considered by the pattern of assistance carried out, which involves researchers and participants collaborating to understand social issues and take actions to bring about social change. The result of the assistance is that the community, especially the women of Tlogo Hamlet, can manage green mustard nuggets and become a business opportunity to increase the productivity and economy of the community. The conclusion is that assistance in increasing the capacities of mothers through green mustard nugget training is needed to realize the economic independence of mothers in Tlogo Hamlet.