bluuebunny/crossref_metadata_2025_split huggingface dataset:
The effect of microlearning educational intervention on communication skills of nurses working in Shiraz Trauma Hospital in 2021
Authors: keshtkaran Zahra , Dadgar Fatemeh , karimian Zahra , Raesi Rasoul , kavoosi Jalal 
Published: January 2025

Background:
Nursing is one of the groups that spends more time with patients. Therefore, communication skills are essential for providing comprehensive care and establishing effective relationships. This study was conducted to investigate the effect of microlearning educational intervention on communication skills of nurses.

Materials and Methods:
This quasi-experimental study was conducted in 2021 by convenience sampling. A total of 197 nurses working in Shiraz Martyr Rajaei Trauma Hospital were enrolled in the study. The educational content in this study included multimedia educational content that was made available to nurses through communication software. The data collection tool consisted of two questionnaires, including a demographic information questionnaire and a queen’s communication skills questionnaire. The data were analyzed using SPSS version 25, and the significance level was set at 5%.

Results:
Most of the participants in the research were female (70.1%), in the age group of 25–35 years. The scores of the main variables of communication skills, including the ability to receive and send messages, emotional control, listening skills, insight into the communication process, communication skills with certainty, and the total score of communication skills, showed a statistically significant difference before and after the intervention (P value < 0.05).

Conclusion:
Microlearning intervention through multimedia education can be an effective method for improving the communication skills of nurses working in hospital settings. Increasing nurses’ awareness of communication skills is also essential, and it is recommended that this training be provided to nurses periodically to promote the nursing profession, especially using microlearning interventions.
The effect of blended educational methods in communication skills in nursing with students’ interactions with patients: A quasi-experimental study
Authors: Kalati Seyed Hossein , Ahmadzadeh Tori Neda , Kalati Javaneh , Norouzi Parashkouh Nastaran , Karimi Hengameh 
Published: January 2025

Background:
Regarding the importance of effective communication in delivering satisfactory nursing care, the current study aims to assess the effect of blended educational methods (lecturing, workshop, role-playing, and group discussion) in nursing students’ communication skills course.

Materials and Methods:
This educational evaluation study was conducted in two educational steps using the quasi-experimental method in Ramsar School of Nursing and Midwifery in 2015. In the first step, communication skills were taught in blended educational methods to all newly admitted nursing students of the fall semester (n = 33). In the second step, after 2 weeks, to evaluate the educational outcome, the communication skills of the students as an experimental group were compared with those of students in the fifth semester as a control group who did not receive any communication skills training (n = 25).

Results:
The results of the paired sample t-test showed a significant difference in the scores for the pre-test and post-test (P < .001). The results of an independent t-test do not indicate any significant difference between the two groups. Only in the listening skills domain, for the item “Avoiding interrupting the audience”, there was a significant difference between the control group and the experimental group (P = 0.04). Two-way multivariate analysis of variance based on Wilks Lambda effect shows that only gender has a significant effect in communication skills terms (F (7, 45) =2.590, P < .001, η2= 0.287).

Conclusion:
According to the results, participating in blended methods for communication skills courses can be as effective in improving communication skills as 2 years of experiential learning of communication skills.
Investigating the electronic health literacy promotion strategies in adolescent girls: A cross-sectional study in Iran
Authors: Tavassoli Elahe , Farsani Sara Eslami , Ganji Forouzan , Dehkordi Ziba Raisi 
Published: January 2025

Background:
Today, a fifth of the world’s population is made up of adolescents aged 10–19, 500 million of these people are adolescent girls, and investing in the health of adolescents is one of the main ways to achieve the Millennium Development Goals. Health concerns are a phenomenon that preoccupies many people at some point in their lives, and in some cases, even though the evidence does not show a specific disease, the person’s concerns are not resolved and health anxiety continues. E-health literacy helps people manage important health issues, make informed health decisions, or communicate with doctors. The present study was conducted with the aim of investigating the electronic health literacy promotion strategies in adolescent girls of Iran: a cross-sectional study.

Materials and Methods:
This cross-sectional study was conducted in 2023 on 351 teenage girls of Iran, whose information was completely recorded in the Sib system. The sampling method was random and was used to collect information from the Electronic Health Literacy Questionnaire and the Health Anxiety Questionnaire. Finally, the data collected by the questionnaire were coded and analyzed after entering into the computer by SPSS version 25 software using descriptive and analytical tests.

Result:
The average age of adolescent girls was 0.834 + 85.15 years. The average score of electronic health literacy in adolescent girls was 79.07 + 14.54, and the average health anxiety score was 83.3 + 35.73. There was an inverse statistical relationship between e-health literacy and health anxiety in girls. The highest average score of health literacy at the age of 17 was for “girls whose fathers are retired and whose mothers are housewives”, fathers and mothers with university education, mothers in the age group of 35–40 years, and fathers in the age group of 40–45 years. There was a significant relationship between e-health literacy and factors such as parents’ occupation, parents’ education, being the second child, and having older siblings (0.05 > 0).

Conclusion:
Improving e-health literacy may be an effective strategy to reduce health anxiety in adolescent girls who are the future mothers of the country. Therefore, developing comprehensive programs for the use of cyberspace, creating simple and understandable media, and educational materials, as well as efficient educational interventions for people with insufficient e-health literacy can be an effective step to develop health literacy skills and ultimately reduce health anxiety among adolescents.
Association between time consumption of electronic screens with eating behaviors and academic performance for pupils in elementary schools
Authors: Al-Wily Mohammed A. S. , Al-Waly Luay A. M. 
Published: January 2025

Background:
Evaluate the association between time consumption of electronic screens with eating behaviors and academic performance for pupils at elementary schools in Mosul city.

Method and Materials:
A descriptive study was carried out at elementary Mosul schools for sixth-grade pupils from December 2023 till March 2024. The sample was selected through two stages, the first stage of elementary schools, which occurred by using the probability (Systematic) sample from 20 elementary schools, the second stage used a nonprobability purposive sample selected sample which entailed 240 pupils from selected elementary schools. A questionnaire was developed that contains four parts: The first part contains two sections: the demographic information of students; the additional portion: information about pupils’ time consumption of electronic screens. third part: the pupils’ eating behaviors. Part four: the pupils’ academic performance. By using a self-administration method for data collection. The questionnaire tool’s validity was confirmed via 13 expert panels. A pilot study was conducted to measure reliability from December 28 to 30, 2023. By Cronbach’s Alpha measurement, the results were 0. 815 at SPSS version 26. The data analysis techniques employed were statistical methods such as descriptive and statistical inference.

Results:
The findings of the study are 73.8% (177) of the sample at a level good academic performance with a total mean of 24.35 and a standard deviation of 8.558 that 78.3% (188) of the sample a good level of pupils’ behavior around food with a total mean of 49.47 and a standard deviation of 12.460. There is a nonsignificant correlation relationship between all-time consumption of electronic screens with all academic performance and behavior around food results in the study at P value ≤ 0.05 except the hours my child uses digital screens per day there is a significant positive correlation relationship with academic performance at P value of 0.007 and also with behavior around food at P value of 0.011.

Conclusion:
The study results regarding the pupils’ behavior around food for time consumption of electronic screens in the study offerings that the majority of the sample results a good level of behavior around food.
Imaging Modalities for Minimally Invasive Pain Intervention for Eagle’s Syndrome
Authors: Arora Prateek , Sangeeth C. , Dey Samarjit , Iqbal Javaid , Shrotriya Charu , Keshwani Manish 
Published: January 2025

Abstract
Patients with an elongated styloid process experience a sharp, stabbing sensation in the throat, which can be extremely discomforting. Available treatment options aim at alleviating the pain symptoms using analgesics, minimally invasive interventions, or surgery. The minimally invasive interventions target the glossopharyngeal nerve, which is near the tip of the elongated styloid process. Due to important neurovascular structures in the vicinity, image guidance increases safety and improves precision. In this series, we discuss various imaging modalities available and their conjecture.
Enhancing neural stem cell integration in the injured spinal cord through targeted PTEN modulation
Authors: Genişcan Simay , Park Hee Hwan , Kim Hyung Soon , Yoo Seokjin , Kim Hyunmi , Jang Byeong Seong , Hwang Dong Hoon , Park Kevin K , Kim Byung Gon 
Published: January 2025

Abstract
Spinal cord injury results in permanent loss of neurological functions due to severance of neural networks. Transplantation of neural stem cells holds promise to repair disrupted connections. Yet, ensuring the survival and integration of neural stem cells into the host neural circuit remains a formidable challenge. Here, we investigated whether modifying the intrinsic properties of neural stem cells could enhance their integration post-transplantation. We focused on phosphatase and tensin homolog (PTEN), a well-characterized tumor suppressor known to critically regulate neuronal survival and axonal regeneration. By deleting Pten in mouse neural stem cells, we observed increased neurite outgrowth and enhanced resistance to neurotoxic environments in culture. Upon transplantation into injured spinal cords, Pten-deficient neural stem cells exhibited higher survival and more extensive rostrocaudal distribution. To examine the potential influence of partial PTEN suppression, rat neural stem cells were treated with short hairpin RNA targeting PTEN, and the PTEN knockdown resulted in significant improvements in neurite growth, survival, and neurosphere motility in vitro. Transplantation of shPTEN-treated neural stem cells into the injured spinal cord also led to an increase in graft survival and migration to an extent similar to that of complete deletion. Moreover, PTEN suppression facilitated neurite elongation from NSC-derived neurons migrating from the lesion epicenter. These findings suggest that modifying intrinsic signaling pathways, such as PTEN, within neural stem cells could bolster their therapeutic efficacy, offering potential avenues for future regenerative strategies for spinal cord injury.
Cell type–dependent role of transforming growth factor-β signaling on postnatal neural stem cell proliferation and migration
Authors: Ware Kierra , Peter Joshua , McClain Lucas , Luo Yu 
Published: January 2025

Abstract
Adult neurogenesis continuously produces new neurons critical for cognitive plasticity in adult rodents. While it is known transforming growth factor-β signaling is important in embryonic neurogenesis, its role in postnatal neurogenesis remains unclear. In this study, to define the precise role of transforming growth factor-β signaling in postnatal neurogenesis at distinct stages of the neurogenic cascade both in vitro and in vivo, we developed two novel inducible and cell type-specific mouse models to specifically silence transforming growth factor-β signaling in neural stem cells in (mGFAP
cre
-ALK5fl/fl-Ai9) or immature neuroblasts in (DCX
creERT2
-ALK5
fl/fl
-Ai9). Our data showed that exogenous transforming growth factor-β treatment led to inhibition of the proliferation of primary neural stem cells while stimulating their migration. These effects were abolished in activin-like kinase 5 (ALK5) knockout primary neural stem cells. Consistent with this, inhibition of transforming growth factor-β signaling with SB-431542 in wild-type neural stem cells stimulated proliferation while inhibited the migration of neural stem cells. Interestingly, deletion of transforming growth factor-β receptor in neural stem cells in vivo inhibited the migration of postnatal born neurons in mGFAP
cre
-ALK5
fl/fl
-Ai9 mice, while abolishment of transforming growth factor-β signaling in immature neuroblasts in DCX
creERT2-ALK5
fl/fl-Ai9 mice did not affect the migration of these cells in the hippocampus. In summary, our data supports a dual role of transforming growth factor-β signaling in the proliferation and migration of neural stem cells in vitro. Moreover, our data provides novel insights on cell type-specific-dependent requirements of transforming growth factor-β signaling on neural stem cell proliferation and migration in vivo.
A crucial role of on-site clinical trial monitoring: Insights from the ethics committee
Authors: Chindhalore Chaitali Ashish , Dakhale Ganesh Natthuji , Gajbhiye Snehalata 
Published: January 2025

Abstract

Background:
On-site monitoring by the institutional ethics committee (IEC) is one of the most effective ways to ensure compliance during research conduct.

Objectives:
The objectives of this study were to analyze the reports of clinical trial (CT) site monitoring conducted by IEC from January 2021 to March 2024 and to assess the impact of the monitoring by analyzing compliance reports submitted by the trial site team.

Methodology:
A retrospective analysis of site monitoring and compliance reports was conducted after obtaining necessary approvals from IEC.

Results:
The present study analyzed 22 reports of site monitoring conducted from 2021 to 2024. A total of 56 deviations were observed during monitoring. The most common deviations observed were related to documentation and record-keeping (31/56). In many cases, logs were incomplete (10/56). Traveling allowance (TA) was given but receipt was not maintained (4/56). Major observed were deducting expenses of consumables from TA, not giving TA and ICF was not signed and dated by patient/LAR. Based on monitoring report, query letters were sent to respective PIs with instructions to submit explanations and compliance reports. The PIs submitted compliance report mentioning CAPA in response to deviations pointed out by ethics committee monitoring team and submitted their reports to the IEC. The percentage improvement in ethical conduct of trials was 96.42%.

Conclusion:
In the present study, active trial site monitoring helped the IEC to identify deviations that were impossible to identify by passive monitoring. Majority of deviations were resolved after being pointed out by IEC highlighting the importance of active monitoring. Thus, on-site CT monitoring is a critical aspect of ethical oversight, ensuring participant safety, maintaining data integrity and credibility, detecting compliance issues, and enhancing trust and transparency.
Risk factor analysis and prediction of multi-organ metastasis in hepatic alveolar echinococcosis
Authors: Xia Pan , Wang Xiang-Qian , Shang-Guan Chao-Liang , Wang Zheng , Xu Wei , Wang Jin-Peng , Liu Zhen , Zhu Hai-Hong 
Published: January 2025

Abstract

Background:
Patients with multiple organ metastases from hepatic alveolar echinococcosis have a high mortality rate. However, predictors of multi-organ metastasis have not been identified. We aimed to develop a nomogram that predicts multi-organ metastasis in patients with hepatic alveolar echinococcosis.

Methods:
We retrospectively screened patients with hepatic alveolar echinococcosis who were treated between January 2016 and December 2021 at Qinghai Provincial People’s Hospital, China. The outcome of the nomogram was multi-organ metastasis of hepatic alveolar echinococcosis. We collected patients’ basic characteristics, disease course, imaging, and blood laboratory results. The Least Absolute Shrinkage Selection Operator (LASSO) analysis selected the predictors preliminarily. A predictive model was constructed by multivariate logistic regression and presented as a nomogram. The performance of the nomogram was measured by the receiver operating characteristic (ROC) curve, calibration diagram, and decision curve analysis (DCA). The model was internally validated by calculating the performance of the validation cohort.

Results:
A total of 353 patients were enrolled in this study. Ninety five (26.9%) patients presented with multi-organ metastases. All participants were randomized into a development cohort (n = 249) and a validation cohort (n = 104). Predictors in this nomogram were the course of the disease, the long diameter of the lesion, multiple intrahepatic lesions, and medication. The ROC curve of the training set was 0.907 (95% CI: 0.870, 0.943). A similar ROC curve was achieved at the validation set (0.927, 95% CI: 0.876, 0.979). The calibration curve demonstrated that the prediction outcome was correlated with the observed outcome.

Conclusion:
The nomogram can predict the risk of multi-organ metastasis in patients with hepatic alveolar echinococcosis, and help clinicians develop or adjust a reasonable diagnosis and treatment plan in time.
Global dynamics of 3D type-K monotone Lotka–Volterra system with the identical intrinsic growth rate
Authors: Liang Fengli , Jiang Jifa , Zhang Xiang 
Published: January 2025

Abstract
In this paper, we classify all global dynamics of the three-dimensional type-K monotone Lotka–Volterra system with the identical intrinsic growth rate inside the compactification of the positive octant of

$\mathbb {R}^{3}$

. By means of the replicator equations, it is proved that this system can have exactly

$35$

topologically different phase portraits. As a consequence, we obtain the necessary and sufficient condition for the system to be bounded in the positive octant and verify that the limit set of any orbit of the compactified vector field associated with the system is an equilibrium.
Intermediate geodesic growth in virtually nilpotent groups
Authors: Bodart Corentin 
Published: January 2025

We give a criterion on pairs

(G,S)

– where

G

is a virtually

s

-step nilpotent group and

S

is a finite generating set – saying whether the geodesic growth is exponential or strictly subexponential. Whenever

s=1,2

, this goes further, and we prove the geodesic growth is either exponential or polynomial. For

s\ge 3

, however, intermediate growth is possible. We exhibit a pair

(G,S)

for which

\gamma_{\mathrm{geod}}(n) \asymp \exp(n^{3/5}\cdot \log(n))

, where

G

contains a

3

-step nilpotent group – the Engel group – as a finite-index subgroup. This is the first example of group with intermediate geodesic growth. Along the way, we prove results on the geometry of virtually nilpotent groups, including asymptotics with error terms for their volume growth, and disprove a conjecture by Breuillard and Le Donne.
New (2Z)-1-(2,4-dinitrophenyl)-2-[(2E)-3-(2-nitrophenyl)prop-2-en-1-ylidene]hydrazine and its V(II) and Ni(II) complexes: synthesis, characterization and in silico sars-CoV-2 inhibition studies
Authors: O. Eberendu K. , I. Nwankwo C. , M. Mac-kalunta O. , I. Iheanyichukwu J. , E. Otuokere I. , C. Nnaji J. , O. Abaleke I. 
Published: January 2025

Hydrazones are an important family of compounds with an azomethine proton (-NHN=CH-), which have been reported to possess high biological activity such as antioxidants, anti-consultants, analgesics, antimicrobial, anti-protozoals, anti-parasitic, anti-platelets, cardio-protective, anti-diabetic, anti-HIV and anti-helminthic. This research was aimed at synthesizing a new aniline hydrazone and its V(II) and Ni(II) complexes, and in silico SARS-CoV-2 inhibition studies. The (2Z)-1-(2,4-dinitrophenyl)-2-[(2E)-3-(2-nitrophenyl)prop-2-en-1-ylidene]hydrazine (DNEAA) was synthesized by the reaction of 2,4-dinitrophenylhydrazine and 3-(2-nitrophenyl)prop-2-enal. DNEAA and its V(II) and Ni(II) complexes were synthesized and characterized by UV-visible, FTIR, and NMR spectroscopy. Molecular docking was performed using Auto Dock Vina software. Spectroscopic analysis suggested that DNEAA coordinated with the metal ions through azomethine nitrogen, NH, two NO2 and two Cl-. An octahedral geometry was proposed for the metal complexes. The ability of DNEAA to chelate V(II) and Ni(II) is hereby assured. Molecular docking results gave binding energies >9.5 kcal/mol. Following these findings, it is recommended that biological studies and preclinical and clinical trials against SARS-CoV-2 protease be carried out.
Bull. Chem. Soc. Ethiop. 2025, 39(4), 673-686.
DOI: https://dx.doi.org/10.4314/bcse.v39i4.6
Diversity of foliar trichomes, trichomes basal insertion cells and cells surrounding the basal insertion cells in family asteraceae
Authors: Arogundade O.O. , Adedeji O. , Ogunlowo I.I. 
Published: January 2025

Foliar trichome morphology, trichome basal insertion cells (TBIC) and cells surrounding trichome insertion basal cells (CSTIBC) on the leaves of fourteen species of family Asteraceae were investigated by light microscopy. TBIC and CSTIBC are the two novel characters investigated in this work, in search of unique character states that could improve the taxonomy of the family. Epidermal peels were made following standard procedure. Data obtained showed that both non-glandular and glandular trichomes were present, the glandular was observed in the genus Vernonia only. The non-glandular trichomes were unicellular, bicellular, tricellular and multicellular uniseriate. Shriveled cells within the multicellular uniseriate cells were common in Emilia sonchifolia and Emilia praertermissa and occurred sparsely in Ageratum conyzoides. Uniquely pigmented multicellular uniseriate trichomes with apical cells shriveled or transparent delimits Bidens pilosa from the other species studied. Amoeboid shaped multicellular uniseriate trichomes delimit Chromolaena odorata from the other species, while Tshaped trichomes (regular and irregular) delimit the genus Vernonia from the other genera studied. Shape and width of apical cells of the trichomes differentiate Vernonia cinerea from Vernonia amygdalina. Surface of trichomes in Aspilia africana, Synedrella nodiflora and Eclipta alba are uniquely papillate and diagnostic for the three species. TIBC have varying shapes with different combinations of 1-4 shapes per species. It is noteworthy that the two species of Emilia can be delimited from each other based on the shapes of the TIBC on the abaxial epidermis. The number of CSTIBC was observed to be the same on the adaxial epidermis of the two species of genus Emilia. Shapes of CSTIBC in the species studied are diverse. Coefficient of Variation for all the characters studied showed species with more variation within each character. Novel characters, TIBC and CSTIBC, were found to be useful as additional tools in the taxonomy of family Asteraceae.