bluuebunny/crossref_metadata_2025_split huggingface dataset:
C-banding characterization of centric fusion and heterochromatin polymorphisms in the water-hyacinth grasshopper, Cornops aquaticum (Orthoptera: Acrididae)
Authors: Colombo Pablo , Bressa María José , Remis María Isabel 
Published: October 2023

Abstract
The water-hyacinth grasshopper, Cornops aquaticum (Orthoptera: Acrididae), shows a clinal variation for 3 Robertsonian translocation (centric fusion) polymorphisms in the southern extreme of its wide geographical distribution. It is a Neotropical semiaquatic grasshopper that lives, feeds, and lays eggs exclusively on floating plants of the family Pontederiaceae, or water-hyacinths, between 23° N (Southern Mexico) and 35° S (Central Argentina and Uruguay). Given the invasive-species status of Pontederia (formerly Eichhornia) crassipes and the voraciousness of these grasshoppers, they were considered as a potential biological control agent in addition to other natural enemies. We already described the association of the rearrangements with geographical and climatic variables, phenotypic variation, trivalent orientation, effects on recombination, and relationship with microsatellite variability. Here we analyze the distribution of constitutive heterochromatin in 2 populations of C. aquaticum in order to (i) provide consistent markers for a better distinction between all chromosomes, those which are involved in the centric fusions, and those which are not, and (ii) describe possible polymorphisms for C-positive supernumerary segments, given that, on conventional staining analysis, it was frequent to find heteromorphic autosomal bivalents. The cytogenetic analysis allowed us to get a detailed characterization of the constitutive heterochromatin distribution, providing unmistakable chromosome markers of the large, fusion-bearing chromosomes as well as the C-positive, polymorphic supernumerary segments.
The Capability Approach and the WHO healthy ageing framework (for the UN Decade of Healthy Ageing)
Authors: Venkatapuram Sridhar , Amuthavalli Thiyagarajan Jotheeswaran 
Published: October 2023

Abstract
This commentary discusses the WHO definition of health ageing in terms of functional abilities, and the problem definition and evidence-based public health response framework outlined in the 2015 WHO Report on Ageing and Health. After identifying the neglect of older people in health policy at national and global levels, some data are presented on the majority of COVID-19 deaths being older people. The discussion then focuses on the underlying ethical and analytical framework of functional abilities provided by the Capability Approach. The approach is presented as distinguishing between achievement and capability, the ethical significance of recognising both, and its inclusion of surrounding social conditions from local to global in assessing wellbeing of older people’s functional abilities. Measurement of functional abilities, informed by the Capabilities Approach, is stated to be an enormous and crucial task in establishing a global baseline, and making progress in improving the health and wellbeing of older people.
Breaking the barriers of data scarcity in drug–target affinity prediction
Authors: Pei Qizhi , Wu Lijun , Zhu Jinhua , Xia Yingce , Xie Shufang , Qin Tao , Liu Haiguang , Liu Tie-Yan , Yan Rui 
Published: October 2023

Abstract
Accurate prediction of drug–target affinity (DTA) is of vital importance in early-stage drug discovery, facilitating the identification of drugs that can effectively interact with specific targets and regulate their activities. While wet experiments remain the most reliable method, they are time-consuming and resource-intensive, resulting in limited data availability that poses challenges for deep learning approaches. Existing methods have primarily focused on developing techniques based on the available DTA data, without adequately addressing the data scarcity issue. To overcome this challenge, we present the Semi-Supervised Multi-task training (SSM) framework for DTA prediction, which incorporates three simple yet highly effective strategies: (1) A multi-task training approach that combines DTA prediction with masked language modeling using paired drug–target data. (2) A semi-supervised training method that leverages large-scale unpaired molecules and proteins to enhance drug and target representations. This approach differs from previous methods that only employed molecules or proteins in pre-training. (3) The integration of a lightweight cross-attention module to improve the interaction between drugs and targets, further enhancing prediction accuracy. Through extensive experiments on benchmark datasets such as BindingDB, DAVIS and KIBA, we demonstrate the superior performance of our framework. Additionally, we conduct case studies on specific drug–target binding activities, virtual screening experiments, drug feature visualizations and real-world applications, all of which showcase the significant potential of our work. In conclusion, our proposed SSM-DTA framework addresses the data limitation challenge in DTA prediction and yields promising results, paving the way for more efficient and accurate drug discovery processes.
The progranulin cleavage product granulin 3 exerts a dominant negative effect on animal fitness
Authors: Wang Austin L , Mambou Edwina A , Kao Aimee W 
Published: October 2023

Abstract
Progranulin is an evolutionarily conserved protein that has been implicated in human neurodevelopmental and neurodegenerative diseases. Human progranulin is comprised of multiple cysteine-rich, biologically active granulin peptides. Granulin peptides accumulate with age and stress, however their functional contributions relative to full-length progranulin remain unclear. To address this, we generated C. elegans strains that produced quantifiable levels of both full-length progranulin/PGRN-1 protein and cleaved granulin peptide. Using these strains, we demonstrated that even in the presence of intact PGRN-1, granulin peptides suppressed the activity of the lysosomal aspartyl protease activity, ASP-3/CTSD. Granulin peptides were also dominant over PGRN-1 in compromising animal fitness as measured by progress through development and stress response. Finally, the degradation of human TDP-43 was impaired when the granulin to PGRN-1 ratio was increased, representing a disease-relevant downstream impact of impaired lysosomal function. In summary, these studies suggest that not only absolute progranulin levels, but also the balance between full-length progranulin and its cleavage products, is important in regulating lysosomal biology. Given its relevance in human disease, this suggests that the processing of progranulin into granulins should be considered as part of disease pathobiology and may represent a site of therapeutic intervention.
A large-scale microRNA transcriptome-wide association study identifies two susceptibility microRNAs, miR-1307-5p and miR-192-3p, for colorectal cancer risk
Authors: Chen Zhishan , Lin Weiqiang , Cai Qiuyin , Kweon Sun-Seog , Shu Xiao-Ou , Tanikawa Chizu , Jia Wei-Hua , Wang Ying , Su Xinwan , Yuan Yuan , Wen Wanqing , Kim Jeongseon , Shin Aesun , Jee Sun Ha , Matsuo Keitaro , Kim Dong-Hyun , Wang Nan , Ping Jie , Shin Min-Ho , Ren Zefang , Oh Jae Hwan , Oze Isao , Ahn Yoon-Ok , Jung Keum Ji , Gao Yu-Tang , Pan Zhi-Zhong , Kamatani Yoichiro , Han Weidong , Long Jirong , Matsuda Koichi , Zheng Wei , Guo Xingyi 
Published: October 2023

Abstract
Transcriptome-wide association studies (TWAS) have identified many putative susceptibility genes for colorectal cancer (CRC) risk. However, susceptibility miRNAs, critical dysregulators of gene expression, remain unexplored. We genotyped DNA samples from 313 CRC East Asian patients and performed small RNA sequencing in their normal colon tissues distant from tumors to build genetic models for predicting miRNA expression. We applied these models and data from genome-wide association studies (GWAS) including 23 942 cases and 217 267 controls of East Asian ancestry to investigate associations of predicted miRNA expression with CRC risk. Perturbation experiments separately by promoting and inhibiting miRNAs expressions and further in vitro assays in both SW480 and HCT116 cells were conducted. At a Bonferroni-corrected threshold of P &lt; 4.5 × 10−4, we identified two putative susceptibility miRNAs, miR-1307-5p and miR-192-3p, located in regions more than 500 kb away from any GWAS-identified risk variants in CRC. We observed that a high predicted expression of miR-1307-5p was associated with increased CRC risk, while a low predicted expression of miR-192-3p was associated with increased CRC risk. Our experimental results further provide strong evidence of their susceptible roles by showing that miR-1307-5p and miR-192-3p play a regulatory role, respectively, in promoting and inhibiting CRC cell proliferation, migration, and invasion, which was consistently observed in both SW480 and HCT116 cells. Our study provides additional insights into the biological mechanisms underlying CRC development.
Convergent evolving finite element approximations of boundary evolution under shape gradient flow
Authors: Gong Wei , Li Buyang , Rao Qiqi 
Published: October 2023

Abstract
As a specific type of shape gradient descent algorithm, shape gradient flow is widely used for shape optimization problems constrained by partial differential equations. In this approach, the constraint partial differential equations could be solved by finite element methods on a domain with a solution-driven evolving boundary. Rigorous analysis for the stability and convergence of such finite element approximations is still missing from the literature due to the complex nonlinear dependence of the boundary evolution on the solution. In this article, rigorous analysis of numerical approximations to the evolution of the boundary in a prototypical shape gradient flow is addressed. First-order convergence in time and $k$th order convergence in space for finite elements of degree $k\geqslant 2$ are proved for a linearly semi-implicit evolving finite element algorithm up to a given time. The theoretical analysis is consistent with the numerical experiments, which also illustrate the effectiveness of the proposed method in simulating two- and three-dimensional boundary evolution under shape gradient flow. The extension of the formulation, algorithm and analysis to more general shape density functions and constraint partial differential equations is also discussed.
Post-processing and improved error estimates of numerical methods for evolutionary systems
Authors: Franz Sebastian 
Published: October 2023

Abstract
We consider evolutionary systems, i.e., systems of linear partial differential equations arising from the mathematical physics. For these systems, there exists a general solution theory in exponentially weighted spaces, which can be exploited in the analysis of numerical methods. The numerical method considered in this paper is a discontinuous Galerkin method in time combined with a conforming Galerkin method in space. Building on our recent paper (Franz, S., Trostorff, S. & Waurick, M. (2019) Numerical methods for changing type systems. IMAJNA, 39, 1009–1038), we improve some of the results, study the dependence of the numerical solution on the weight parameter and consider a reformulation and post-processing of its numerical solution. As a by-product, we provide error estimates for the dG-C0 method. Numerical simulations support the theoretical findings.
Inpatient nurses’ preferences and decisions with risk information visualization
Authors: Jeffery Alvin D , Reale Carrie , Faiman Janelle , Borkowski Vera , Beebe Russ , Matheny Michael E , Anders Shilo 
Published: October 2023

Abstract

Objective
We examined the influence of 4 different risk information formats on inpatient nurses’ preferences and decisions with an acute clinical deterioration decision-support system.

Materials and methods
We conducted a comparative usability evaluation in which participants provided responses to multiple user interface options in a simulated setting. We collected qualitative data using think aloud methods. We collected quantitative data by asking participants which action they would perform after each time point in 3 different patient scenarios.

Results
More participants (n = 6) preferred the probability format over relative risk ratios (n = 2), absolute differences (n = 2), and number of persons out of 100 (n = 0). Participants liked average lines, having a trend graph to supplement the risk estimate, and consistent colors between trend graphs and possible actions. Participants did not like too much text information or the presence of confidence intervals. From a decision-making perspective, use of the probability format was associated with greater concordance in actions taken by participants compared to the other 3 risk information formats.

Discussion
By focusing on nurses’ preferences and decisions with several risk information display formats and collecting both qualitative and quantitative data, we have provided meaningful insights for the design of clinical decision-support systems containing complex quantitative information.

Conclusion
This study adds to our knowledge of presenting risk information to nurses within clinical decision-support systems. We encourage those developing risk-based systems for inpatient nurses to consider expressing risk in a probability format and include a graph (with average line) to display the patient’s recent trends.
Evaluating the impact of cultivar selection on carrot weevil (Coleoptera: Curculionidae) damage and foliar insect pest assemblages in carrot
Authors: Justus Emily J , Long Elizabeth Y 
Published: October 2023

Abstract
Knowledge of specialty crop cultivars with resistance against insect pests is limited, and this may serve as a barrier to implementing host-plant resistance as part of an integrated pest management strategy. Carrot (Daucus carota L.) (Apiaels: Apiaceae)is a valuable specialty crop with a diversity of insect pests and cultivars that differ in physical and chemical qualities that influence insect pest preferences. To investigate the role of cultivar as a tool to reduce insect pest damage, we evaluated 7 carrot cultivars in replicated laboratory and field trials in IN and OH, USA in 2021. During June and July, we documented oviposition and feeding damage by the carrot weevil (Listronotus oregonenesis LeConte) (Coleoptera: Curculionidae) and used faunistic analysis to measure the abundance and diversity of foliar insect assemblages on each cultivar. We found no significant differences in oviposition and root damage across cultivars in the field, with mean cumulative egg scars ranging from 1.83 ± 1.40 in “Red Core Chantenay” to 5.17 ± 2.62 in “Cosmic Purple”. However, there was a positive correlation between the cumulative number of egg scars and number of trichomes on petioles. Similarly, no-choice laboratory bioassays revealed no significant differences in mean cumulative egg scars, ranging from 5.00 ± 1.15 in “Red Core Chantenay” to 10.63 ± 1.02 in “Danvers 126”. Predominant insect pests differed across cultivars, but Cicadellidae was common across all cultivars. Interestingly, only 1 beneficial insect family, Pteromalidae, was predominant across cultivars. This research highlights the impact of cultivar selection on the diversity and damage potential of insect pests in carrot production.
The first case of SARS-CoV-2-induced eosinophilic fasciitis
Authors: Boussaa Hiba , Kamoun Mariem , Miladi Saoussen , Makhlouf Yasmine , Abdelghani Kawther Ben , Fazaa Alia , Laatar Ahmed 
Published: October 2023

ABSTRACT
Eosinophilic fasciitis (EF), also known as Shulman syndrome, is a rare auto-immune fibrosing disorder of the fascia. Etiopathogeny of EF is still unclear. Nowadays, it is widely known that severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) may induce hyper-stimulation of the immune system. Several cases with fasciitis and rhabdomyolysis induced by coronavirus disease 2019 vaccines have been reported in the literature. Herein, we report the first case of EF possibly triggered by SARS-CoV-2 infection. A 45-year-old Tunisian woman, with no medical history, presented to our department with severe widespread muscle pain noticed one month after a SARS-CoV-2 infection. Physical examination showed an induration of the skin and subcutaneous tissue of the arms, forearms and legs with a restricted joint mobility. The level of eosinophils was 430 E/mm3 (6.1%) [1–4%]. Electromyography and creatine kinase levels were normal. Myositis-related antibodies were negative. Magnetic resonance imaging of the left arm showed high-intensity signal and thickness of the fascia without evidence of muscle or bone involvement. A muscular biopsy from the right deltoid showed thickening and inflammation of the fascia. The patient received intraveinous injections of 1000 mg of methylprednisolone for 3 days with an oral relay of 1 mg/kg per day of prednisone equivalent during 4 weeks. At one-month follow-up, a significant improvement of the skin induration and myalgia was observed, with a disappearance of the biological inflammatory syndrome. This brief report suggests a potential link between SARS-CoV-2 infection and new-onset of auto-immune fasciitis.
Dietary approaches for controlling cancer by limiting the Warburg effect: a review
Authors: Shimi Ghazaleh 
Published: October 2023

Abstract
Cancer is a mysterious disease. Among other alterations, tumor cells, importantly, have metabolic modifications. A well-known metabolic modification commonly observed in cancer cells has been termed the Warburg effect. This phenomenon is defined as a high preference for glucose uptake, and increased lactate production from that glucose, even when oxygen is readily available. Some anti-cancer drugs target the proposed Warburg effect, and some dietary regimens can function similarly. However, the most suitable dietary strategies for treating particular cancers are not yet well understood. The aim of this review was to describe findings regarding the impact of various proposed dietary regimens targeting the Warburg effect. The evidence suggests that combining routine cancer therapies with diet-based strategies may improve the outcome in treating cancer. However, designing individualized therapies must be our ultimate goal.
Supplementation with l-arginine and nitrates vs age and individual physiological reactivity
Authors: Kurhaluk Natalia 
Published: October 2023

Abstract

Ageing is a natural ontogenetic phenomenon that entails a decrease in the adaptive capacity of the organism, as a result of which the body becomes less adaptable to stressful conditions. Nitrate and nitrite enter the body from exogenous sources and from nitrification of ammonia nitrogen by intestinal microorganisms. This review considers the mechanisms of action of l-arginine, a known inducer of nitric oxide (NO) biosynthesis, and nitrates as supplements in the processes of ageing and aggravated stress states, in which mechanisms of individual physiological reactivity play an important role. This approach can be used as an element of individual therapy or prevention of premature ageing processes depending on the different levels of initial reactivity of the functional systems. A search was performed of the PubMed, Scopus, and Google Scholar databases (n = 181 articles) and the author’s own research (n = 4) up to May 5, 2023. The review presents analyses of data on targeted treatment of NO generation by supplementation with l-arginine or nitrates, which is a promising means for prevention of hypoxic conditions frequently accompanying pathological processes in an ageing organism. The review clarifies the role of the individual state of physiological reactivity, using the example of individuals with a high predominance of cholinergic regulatory mechanisms who already have a significant reserve of adaptive capacity. In studies of the predominance of adrenergic influences, a poorly trained organism as well as an elderly organism correspond to low resistance, which is an additional factor of damage at increased energy expenditure.

Conclusion
It is suggested that the role of NO synthesis from supplementation of dietary nitrates and nitrites increases with age rather than from oxygen-dependent biosynthetic reactions from l-arginine supplementation.
Frequency of anthropometric implausible values estimated from different methodologies: a systematic review and meta-analysis
Authors: Santana dos Santos Iolanda Karla , Borges dos Santos Pereira Débora , Cumpian Silva Jéssica , de Oliveira Gallo Caroline , de Oliveira Mariane Helen , Pereira de Vasconcelos Luana Cristina , Conde Wolney Lisbôa 
Published: October 2023

Abstract

Context
Poor anthropometric data quality affect the prevalence of malnutrition and could harm public policy planning.

Objective
This systematic review and meta-analysis was designed to identify different methods to evaluate and clean anthropometric data, and to calculate the frequency of implausible values for weight and height obtained from these methodologies.

Data Sources
Studies about anthropometric data quality and/or anthropometric data cleaning were searched for in the MEDLINE, LILACS, SciELO, Embase, Scopus, Web of Science, and Google Scholar databases in October 2020 and updated in January 2023. In addition, references of included studies were searched for the identification of potentially eligible studies.

Data Extraction
Paired researchers selected studies, extracted data, and critically appraised the selected publications.

Data Analysis
Meta-analysis of the frequency of implausible values and 95% confidence interval (CI) was estimated. Heterogeneity (I2) and publication bias were examined by meta-regression and funnel plot, respectively.

Results
In the qualitative synthesis, 123 reports from 104 studies were included, and in the quantitative synthesis, 23 studies of weight and 14 studies of height were included. The study reports were published between 1980 and 2022. The frequency of implausible values for weight was 0.55% (95%CI, 0.29–0.91) and for height was 1.20% (95%CI, 0.44–2.33). Heterogeneity was not affected by the methodological quality score of the studies and publication bias was discarded.

Conclusions
Height had twice the frequency of implausible values compared with weight. Using a set of indicators of quality to evaluate anthropometric data is better than using indicators singly.

Systematic Review Registration
PROSPERO registration no. CRD42020208977.