bluuebunny/crossref_metadata_2025_split huggingface dataset:
Cohort profile: The Trauma Outcomes Project, a prospective study of New Zealanders experiencing major trauma
Authors: Owen Helen E , Wyeth Emma H , Maclennan Brett , Barson David , McBride Paul , Gabbe Belinda J , Civil Ian , Derrett Sarah 
Published: November 2023

PurposePatient-reported outcome measures (PROMs) are useful for trauma registries interested in monitoring patient outcomes and trauma care quality. PROMs had not previously been collected by the New Zealand Trauma Registry (NZTR). More than 2500 New Zealanders are admitted to hospital for major trauma annually. The Trauma Outcomes Project (TOP) collected PROMs postinjury from three of New Zealand’s (NZ’s) major trauma regions. This cohort profile paper aims to provide a thorough description of preinjury and 6 month postinjury characteristics of the TOP cohort, including specifically for Māori (Indigenous population in Aotearoa me Te Waipounamu/NZ).ParticipantsBetween July 2019 and June 2020, 2533 NZ trauma patients were admitted to one of 22 hospitals nationwide for major trauma and included on the NZTR. TOP invited trauma patients (aged ≥16 years) to be interviewed from three regions; one region (Midlands) declined to participate. Interviews included questions about health-related quality of life, disability, injury recovery, healthcare access and household income adequacy.Findings to dateTOP recruited 870 participants, including 119 Māori. At 6 months postinjury, most (85%) reported that the injury still affected them, 88% reported problems with≥1 of five EQ-5D-5L dimensions (eg, 75% reported problems with pain or discomfort, 71% reported problems with usual activities and 52% reported problems with mobility). Considerable disability (World Health Organization Disability Assessment Schedule, WHODAS II, score ≥10) was reported by 45% of participants. The prevalence of disability among Māori participants was 53%; for non-Māori it was 44%. Over a quarter of participants (28%) reported trouble accessing healthcare services for their injury. Participation in paid work decreased from 63% preinjury to 45% 6 months postinjury.Future plansThe 12 and 24 month postinjury data collection has recently been completed; analyses of 12 month outcomes are underway. There is potential for longer-term follow-up interviews with the existing cohort in future. TOP findings are intended to inform the National Trauma Network’s quality improvement processes. TOP will identify key aspects that aid in improving postinjury outcomes for people experiencing serious injury, including importantly for Māori.
Post Intensive Care Syndrome in Swiss Paediatric survivors and their Families (PICSS-PF): a national, multicentre, longitudinal study protocol
Authors: Rahmaty Zahra , Manning Joseph C , Perez Maria-Helene , Ramelet Anne-Sylvie 
Published: November 2023

IntroductionPaediatric intensive care units (PICUs) survivors and their families often experience widespread morbidity and psychosocial consequences after discharge, known as post-intensive care syndrome in paediatrics (PICS-p). In Switzerland, more than 5000 children are admitted to PICUs each year, and despite the high survival rate, there are no data on post-PICU recovery. This study aims to investigate PICS in children and families and identify its associated factors.Methods and analysisThis is a national, multicentre, longitudinal, observational study that includes PICU survivors, main family caregivers and siblings (n=1300) recruited from the eight Swiss accredited PICUs with follow-up at discharge, 1, 3 and 6 months after discharge from the PICU. Data will be collected on the domains of physical, emotional, social and cognitive health, as well as factors affecting the outcome related to demographics, clinical specification, PICU and family environment, as well as community and social resources. Structural equation models and growth mixture models will analyse the outcomes, and the heterogeneity of recovery that shed light on the diverse recovery experiences of children and their families. The study identifies risk and protective factors with a focus on the influence of social and familial resources. It will also explore the mutual impact of the child’s recovery and parent/sibling psychosocial health.Ethics and disseminationThe protocol is approved by the CER-VD ethics committee. Participants will be provided with verbal and written explanations of the study, and their privacy and anonymity will be protected throughout the process. The results will be presented at local and international conferences.Approval numberSwiss ethics committees ID: 2022-02128, representing the eight cantons for both French and German-speaking parts of Switzerland.
Hidden sodium in effervescent-tablet dietary supplements and over-the-counter drugs: a comparative cross-sectional study
Authors: Kunz Michael , Götzinger Felix , Jacobs Cathy M , Lauder Lucas , Ukena Christian , Meyer Markus R , Laufs Ulrich , Schulz Martin , Böhm Michael , Mahfoud Felix 
Published: November 2023

ObjectiveDietary sodium intake represents a risk factor for cardiovascular disease and mortality. The study sought to analyse the sodium content of effervescent dietary supplements and drugs in Germany and the USA.DesignComparative cross-sectional study.Setting and methodsThe sodium content of 39 dietary supplement effervescent tablets available in Germany was measured in May and June 2022 using optical emission spectrometry with inductively coupled argon plasma. The sodium content of 33 common pharmacy-only effervescent tablets (over-the-counter (OTC) drugs) in Germany was obtained from the summary of product characteristics. We compared the sodium content of the measured German dietary supplement effervescent tablets to that of 51 dietary supplement effervescent tablets available in the USA (data: National Institutes of Health’s Dietary Supplement Label Database).ResultsThe measured sodium content in the German dietary supplements was 283.9±122.6 mg sodium/tablet, equivalent to 14±6% of the maximum recommended daily sodium intake (MRDSI). Vitamin products had the highest (378.3±112.8 mg, 19±6% of MRDSI), and calcium products had the lowest mean sodium content (170.4±113.2 mg, 9±6% of MRDSI). Vitamin products contained significantly more sodium than magnesium (378.3 mg vs 232.7 mg; p=0.004), calcium (378.3 mg vs 170.4 mg; p=0.006) and mineral products (378.3 mg vs 191.6 mg; p=0.048). The sodium content measured in products available in Germany was higher when compared with the declared sodium content on the label of the products sold in the USA (283.9 mg vs 190.0 mg; p<0.001). The median summary of product characteristics-declared sodium content of a single dose of the German OTC drugs was 157.0 mg (IQR: 98.9–417.3 mg); pain/common cold drugs contained the most sodium (median: 452.1 mg; IQR: 351.3–474.0 mg).ConclusionEffervescent tablets of nutritional supplements and OTC drugs contain high amounts of sodium, which often is not disclosed.
Effect of women’s literacy status on maternal healthcare services utilisation in Ethiopia: a stratified analysis of the 2019 mini Ethiopian Demographic and Health Survey
Authors: Handebo Simegnew , Demie Takele Gezahegn , Gessese Getachew Tilahun , Woldeamanuel Berhanu Teshome , Biratu Tolesa Diriba 
Published: November 2023

ObjectivesMaternal mortality remains unacceptably high in sub-Saharan Africa with 533 maternal deaths per 100 000 live births, accounting for 68% of all maternal deaths worldwide. Most maternal deaths could be prevented by adequate maternal health service use. The study examined the effect of literacy status on maternal health services utilisation among reproductive-age women in Ethiopia.DesignA cross-sectional study.SettingsEthiopia.ParticipantsA weighted sample of 3839 reproductive-age women who gave birth in the last 5 years preceding the survey and whose literacy status was measured were included in this study. The survey used a two-stage stratified cluster sampling technique.Primary and secondary outcome measuresThis study used a dataset from the recent Ethiopia Mini Demographic and Health Surveys. We assessed the maternal health service utilisation among reproductive-age women. Multivariable logistic regression analyses were employed to assess the association between literacy status and maternal healthcare utilisation while controlling for other factors. Adjusted OR with a 95% CI was reported.ResultsAbout 63.8% of reproductive-age women were illiterate. The prevalence of antenatal care (ANC) 1, ANC 4, skilled birth attendance and postnatal care (PNC) services utilisation was 74.9%, 43.5%, 51.9% and 32.0%, respectively. Literate women had significantly higher ANC 1, ANC 4, skilled birth attendance, and PNC services utilisation than illiterate women (p<0.001). Regional variation, wealth status, age at first birth, birth order and birth intervals were significantly associated with maternal healthcare utilisation among both literate and illiterate women. Similarly, ANC booking timing and utilisation, age of household head and religious affiliation were associated with institutional delivery and PNC utilisation.ConclusionLiterate women had a significantly higher maternal healthcare services utilisation than illiterate, modified by sociodemographic and obstetric-related factors. Hence, wholehearted efforts should be directed towards educating and empowering women.
Machine learning facilitates the prediction of long-term mortality in patients with tricuspid regurgitation
Authors: Deb Brototo , Scott Christopher , Pislaru Sorin V , Nkomo Vuyisile T , Kane Garvan Christopher , Alkhouli Mohamad , Crestanello Juan A , Arruda-Olson Adelaide , Pellikka Patricia A , Anand Vidhu 
Published: November 2023

ObjectiveTricuspid regurgitation (TR) is a prevalent valve disease associated with significant morbidity and mortality. We aimed to apply machine learning (ML) to assess risk stratification in patients with ≥moderate TR.MethodsPatients with ≥moderate TR on echocardiogram between January 2005 and December 2016 were retrospectively included. We used 70% of data to train ML-based survival models including 27 clinical and echocardiographic features to predict mortality over a 3-year period on an independent test set (30%). To account for differences in baseline comorbidities, prediction was performed in groups stratified by increasing Charlson Comorbidity Index (CCI). Permutation feature importance was calculated using the best-performing model separately in these groups.ResultsOf 13 312 patients, mean age 72 ± 13 years and 7406 (55%) women, 7409 (56%) had moderate, 2646 (20%) had moderate–severe and 3257 (24%) had severe TR. The overall performance for 1-year mortality by 3 ML models was good, c-statistic 0.74–0.75. Interestingly, performance varied between CCI groups, (c-statistic = 0.774 in lowest CCI group and 0.661 in highest CCI group). The performance decreased over 3-year follow-up (average c-index 0.78). Furthermore, the top 10 features contributing to these predictions varied slightly with the CCI group, the top features included heart rate, right ventricular systolic pressure, blood pressure, diuretic use and age.ConclusionsMachine learning of common clinical and echocardiographic features can evaluate mortality risk in patients with TR. Further refinement of models and validation in prospective studies are needed before incorporation into the clinical practice.
Primary versus iatrogenic (post-PCI) coronary microvascular dysfunction: a wire-based multimodal comparison
Authors: Hasdemir Hakan , Taş Ahmet , Cevik Erdem , Alan Yaren , Broyd Christopher J , Ozcan Alp , Sonsoz Mehmet R , Kara Ilke , Demirtakan Zeynep G , Parker Kim , Perera Divaka , Umman Sabahattin , Sezer Murat 
Published: November 2023

BackgroundAlthough there are studies examining each one separately, there are no data in the literature comparing the magnitudes of the iatrogenic, percutaneous coronary intervention (PCI)-induced, microvascular dysfunction (Type-4 CMD) and coronary microvascular dysfunction (CMD) in the setting of ischaemia in non-obstructed coronary arteries (INOCA) (Type-1 CMD).ObjectivesWe aimed to compare the characteristics of Type-1 and Type-4 CMD subtypes using coronary haemodynamic (resistance and flow-related parameters), thermodynamic (wave energy-related parameters) and hyperemic ECG changes.MethodsCoronary flow reserve (CFR) value of <2.5 was defined as CMD in both groups. Wire-based multimodal perfusion markers were comparatively analysed in 35 patients (21 INOCA/CMD and 14 CCS/PCI) enrolled inNCT05471739study.ResultsBoth groups had comparably blunted CFR values per definition (2.03±0.22 vs 2.11±0.37; p: 0.518) and similar hyperemic ST shift in intracoronary ECG (0.16±0.09 vs 0.18±0.07 mV; p: 0.537). While the Type-1 CMD was characterised with impaired hyperemic blood flow acceleration (46.52+12.83 vs 68.20+28.63 cm/s; p: 0.017) and attenuated diastolic microvascular decompression wave magnitudes (p=0.042) with higher hyperemic microvascular resistance (p<0.001), Type-4 CMD had blunted CFR mainly due to higher baseline flow velocity due to post-occlusive reactive hyperemia (33.6±13.7 vs 22.24±5.3 cm/s; p=0.003).ConclusionsThe perturbations in the microvascular milieu seen in CMD in INOCA setting (Type-1 CMD) seem to be more prominent than that of seen following elective PCI (Type-4 CMD), although resulting reversible ischaemia is equally severe in the downstream myocardium.
Spectroscopic survey of higher-lying states of $$B_c$$ meson family
Authors: Li Xue-Jian , Li Yu-Shuai , Wang Fu-Lai , Liu Xiang 
Published: November 2023

AbstractIn this work, we investigate the complete spectroscopy of the $$B_c$$

B
c

mesons, with a special focus on the consideration of the unquenched effects. To account for such effects, we employ the modified Godfrey–Isgur model and introduce a screening potential. The resulting mass spectrum of the concerned higher $$B_c$$

B
c

states is then presented, showing significant deviations after considering the unquenched effects. This emphasizes the importance of considering the unquenched effects when studying of the higher $$B_c$$

B
c

mesons. Furthermore, we determine the corresponding spatial wave functions of these $$B_c$$

B
c

mesons, which have practical applications in subsequent studies of their decays. These decays include two-body Okuba–Zweig–Iizuka allowed strong decays, dipion transitions between $$B_c$$

B
c

mesons, radiative decays, and some typical weak decays. With the ongoing high-luminosity upgrade of the Large Hadron Collider, we expect the discovery of additional $$B_c$$

B
c

states in the near future. The knowledge gained from the mass spectrum and the different decay modes will undoubtedly provide valuable insights for future experimental explorations of these higher $$B_c$$

B
c

mesons.
Electron injection into superconducting trivalent fullerides close to the Mott transition boundary
Authors: Matsui Keisuke , Yoshikane Naoya , Terzidou Anastasia G. V. , Arvanitidis John , Kawaguchi Shogo , Kubota Yoshiki , Prassides Kosmas 
Published: November 2023

To date, superconductivity in fullerides has been almost exclusively tuned by (chemical or physical) pressure control of the conduction bandwidth, W at half filling. This contrasts sharply with the extensive control of the superconducting transition temperature, [Formula: see text] in atom-based superconductors such as the cuprates and iron pnictides and chalcogenides via changes in valence (bandfilling). Here, we investigate the effect of doping away from the exactly half-filled [Formula: see text] level in quaternary face-centered-cubic (fcc) — structured fulleride solids with nominal composition ([Formula: see text]Csx)[Formula: see text][Formula: see text] ([Formula: see text]), in which divalent [Formula: see text] ions partially replace monovalent alkali [Formula: see text]/[Formula: see text] ions. The resulting charged-modified fullerides in which the [Formula: see text] bandwidth is also varied with changing x show a dome-shaped dependence of [Formula: see text] on interfullerene separation in analogy with their half-filled antecedents. However, following electron injection beyond half-filling, the superconductivity dome is found to shift towards shorter interfullerene separations, i.e. towards increased conduction bandwidths.
How Often Do Patients Need Retreatment After Surgery for Subdural Hematoma? A Nationwide Readmission Database Analysis
Authors: Nazari Pouya , Golnari Pedram , Metcalf‐Doetsch William N. , Potts Matthew B. , Jahromi Babak S. 
Published: November 2023

Background
The incidence of subdural hematoma is increasing as the average age in the United States rises, with reported high recurrence and reoperation rates. We therefore aimed to have a better understanding of retreatment following surgical evacuation of subdural hematoma in real‐world practice.

Methods
Data were extracted from the latest available Nationwide Readmissions Database (2016–2019). Adult patients diagnosed with subdural hematoma who had burr‐hole or craniotomy were included in the study.

Results

Retreatment rates were relatively low in both cohorts, with patients in the burr‐hole cohort having a slightly higher rate of retreatment compared with the craniotomy cohort (8.4% versus 6.6%,
P
<0.001). The majority (>95%) of retreatments occurred within 90 days of initial treatment, and further follow‐up did not demonstrably increase retreatment on Kaplan–Meier analysis. Retreatment rates remained consistent during the 4‐year study period in both burr‐hole (7.2%–10.4%), and craniotomy cohorts (6.4%–6.8%).

Conclusions
Analysis of a large national database of unselected patients shows retreatment rates after surgery for subdural hematoma are lower than suggested by prior studies. Almost all retreatments occur within 90 days after initial treatment, which may have implications for length of follow‐up for such patients.
Disappearing repositories – taking an infrastructure perspective on the long-term availability of research data
Authors: Strecker Dorothea , Pampel Heinz , Schabinger Rouven , Weisweiler Nina Leonie 
Published: November 2023

Abstract
Currently, there is limited research investigating the phenomenon of research data repositories being shut down, and the impact this has on the long-term availability of data. This paper takes an infrastructure perspective on the preservation of research data by using a registry to identify 191 research data repositories that have been closed and presenting information on the shutdown process.
The results show that 6.2 % of research data repositories indexed in the registry were shut down. The risks resulting in repository shutdown are varied. The median age of a repository when shutting down is 12 years. Strategies to prevent data loss at the infrastructure level are pursued to varying extent. 44 % of the repositories in the sample migrated data to another repository, and 12 % maintain limited access to their data collection. However, both strategies are not permanent solutions.
Finally, the general lack of information on repository shutdown events as well as the effect on the findability of data and the permanence of the scholarly record are discussed.

Peer Review
https://www.webofscience.com/api/gateway/wos/peer-review/10.1162/qss_a_00277
Evaluation of the Safety of Slow IV Push Versus Slow IV Infusion Administration of 23.4% Sodium Chloride
Authors: Iskaros Olivia , Arnouk Serena , Papadopoulos John , Merchan Cristian 
Published: November 2023

Background and Purpose Increased intracranial pressure due to cerebral edema is a medical emergency in which 23.4% sodium chloride (23.4% NaCl) may be a lifesaving intervention. Currently, safety data is limited on slow IV push (IVP) administration. The purpose of this study was to evaluate the safety of IVP administration of 23.4% NaCl and determine the number of infusion-related adverse events (IRAEs) compared to slow IV infusion (SIV) administration. Methods We performed a retrospective review of patients who received a dose of 23.4% NaCl at the (removed institution) from January 2015 to June 2020 as either SIV over 30 minutes or IVP over 2-5 minutes. Results In total, 81 patients, 55 in the IVP group and 26 in the SIV group, were included in the analysis. There was a significantly faster time from order entry to dose completion (IVP 25 [13,58] vs SIV 73 [55,113] minutes, P < .001). There was no difference in IRAEs between the groups (IVP 17 [31%] vs SIV 6 [23%], P = .466). Hypotension was most common (IVP 13 [24%] vs SIV 5 [19%], P = .656) followed by bradycardia (IVP 6 [11%] vs SIV 1 [4%], P = .291). There were no extravasations reported. Conclusions Overall, among a cohort of patients with cerebral edema, we found no difference in the incidence of IRAEs between SIV and IVP administration of 23.4% NaCl, and found a faster time to complete administration fssor the latter. In emergent scenarios where time may impact neurologic function, 23.4% NaCl administered IVP may be an alternative to SIV administration.
Implementation of eLearning solutions for patients with chronic pain conditions
Authors: Philpot Lindsey M. , Ahrens Desiree J. , Eastman Ryan J. , Mohabbat Arya B. , Mosman Elton A. , Ramar Priya , Reinschmidt Karen J. , Roellinger Daniel L. , Ebbert Jon O. 
Published: November 2023

Background Digital and mobile (mHealth) solutions are online or application-based services intended to support individuals with health needs. Despite evidence supporting the use of mHealth for patients with chronic pain, and the increasing desire of these types of solutions by both patients and providers, adoption of mHealth solutions remains limited. Implementation mapping can serve as a practical method to facilitate implementation and adoption of mHealth solutions within healthcare settings. Methods Implementation mapping was used to develop implementation strategies based on contextual determinants organized within the Consolidated Framework for Implementation Research (CFIR) for mHealth eLearning solutions across an integrated, multi-site healthcare system. We describe our experience identifying stakeholders, delineating implementation facilitators and barriers, defining implementation outcomes using RE-AIM (Reach, Effectiveness, Adoption, Implementation, Maintenance) framework, outlining initial implementation strategies, and iterating on implementation strategies. Results A total of 30 implementation strategies were identified and implemented. Over the first year, primary and specialty care providers across all the clinical sites ( n = 70) placed 2559 orders for the mHealth solution. Most patients reported receiving the mHealth eLearning module (74%), and most patients felt that the tool improved their knowledge regarding their condition (82%) and their ability to provide self-care related to the condition (73%). Conclusion Practical applications of implementation science methods can help enable change within healthcare settings. Implementation mapping is an exercise that can engage stakeholders to facilitate the incorporation of new methods of care delivery, including mHealth solutions.