bluuebunny/crossref_metadata_2025_split huggingface dataset:
Recycling and transport of evapotranspiration over the Tibetan Plateau: Detected by a water vapour tracer method embedded in regional climate model
Authors: Tang Yingge , Dan Jingyu , Zhang Meng , Jiang Haojun , Gao Yanhong 
Published: November 2023

AbstractWith an average elevation of 4000 m, the Tibetan Plateau (TP) exerts a global influence on weather and climate. To investigate and quantify the impact of terrestrial evapotranspiration (ET) over the TP on both local and downstream regions, we employed the water vapour tracer (WVT) method integrated into the Weather Research and Forecasting (WRF) model to track the propagation of evaporative moisture across the TP. Based on precipitation landing location, termination of evaporative moisture over the TP was categorized into recycled ET (ETin, which precipitates inside the TP) and moving‐out ET (ETout, which precipitates outside the TP). Our findings reveal that ETin dominates 70% of ET moisture termination over the TP, exhibiting a decrease gradient from eastern to western regions. The majority of ETout spreads eastward with some reaching southward. Seasonal variations indicate that more than 75% of ET recycles during summer, while more ET moves out from TP in spring and autumn. The interplay between convection and advection leads to different reach‐outs for moving‐out ET in summer compared to other seasons: strong convection and diabatic heating plus a relative weak large‐scale advection result in shorter reach‐outs during summer, whereas weaker convection combined with strong advection leads to longer ‐reach‐outs in other seasons. This study enhances our understanding of terrestrial ET moisture transport over the TP as well as its mechanism influencing both local water cycle dynamics and downstream processes.
Influence of industrial blanching, cutting, and freezing treatments on in vitro gastrointestinal digestion stability of orange (Citrus sinensis L.) and lemon (Citrus limon L.) peel polyphenols
Authors: Ozdemirli Nurdan , Kamiloglu Senem 
Published: November 2023

AbstractBACKGROUNDCitrus peels, which are often discarded as waste in the food‐processing industry, are rich sources of polyphenols. The aim of the current study was to investigate the influence of an industrial freezing process along with blanching and cutting pretreatments on the in vitro gastrointestinal digestion stability of orange (Citrus sinensis L.) and lemon (Citrus limon L.) peel polyphenols. The major polyphenols were identified and quantified with ultra‐performance liquid chromatography‐electrospray tandem mass spectrometry (UPLC‐ESI‐MS/MS) and high performance liquid chromatography‐photodiode array detector (HPLC‐PDA), respectively.RESULTSThe results revealed that hesperidin and chlorogenic acid were the predominant flavonoid and phenolic acids in orange peels whereas, for lemon peels, eriocitrin and caffeic acid were the dominant flavonoid and phenolic acids, respectively. Blanching pretreatment enhanced the levels of major flavonoids in orange and lemon peels (by 39–82% and 54–146%, respectively) (P < 0.05) after in vitro gastrointestinal digestion. On the other hand, the application of cutting treatment after blanching significantly reduced the levels of flavonoids (23–62%) (P < 0.05); however, there was no statistically significant difference between the phenolic acid levels of cut and uncut citrus peels. Overall, the bioaccessibility of individual flavonoids and phenolic acids from frozen orange peels was generally slightly lower than that of untreated peels (9–34% and 9–49%, respectively). Nevertheless, frozen lemon peels contained higher bioaccessible flavonoids and phenolic acids in comparison with untreated peels (40–172% and 32–98%, respectively).CONCLUSIONThese results suggest that industrial freezing steps could largely preserve the bioaccessibility of polyphenols in orange and lemon peels. © 2023 The Authors. Journal of The Science of Food and Agriculture published by John Wiley & Sons Ltd on behalf of Society of Chemical Industry.
Repeat sentinel lymph node surgery for locally recurrent breast cancer after prior mastectomy
Authors: Schulze Amy K. , Hoskin Tanya L. , Mrdutt Mary M. , Mutter Robert W. , Hieken Tina J. 
Published: November 2023

AbstractBackground and ObjectivesCurrent NCCN guidelines discourage repeat sentinel lymph node (SLN) surgery in patients with local recurrence (LR) of breast cancer following prior mastectomy. This study addresses the feasibility and therapeutic impact of this approach.MethodsWe identified 73 patients managed with repeat SLN surgery for post−mastectomy isolated LR. Lymphatic mapping was performed using radioisotope with or without lymphoscintigraphy and/or blue dye. Successful SLN surgery was defined as retrieval of ≥1 SLN.ResultsSLN surgery was successful in 65/73 (89%), identifying a median of 2 (range 1–4) SLNs, with 10/65 (15%) SLN‐positive. Among these, 5/10 (50%) proceeded to ALND. In unsuccessful cases, 1/8 (13%) proceeded to ALND. Seven of 10 SLN‐positive patients and 50/55 SLN‐negative patients received adjuvant radiotherapy. Chemotherapy was administered in 31 (42%) and endocrine therapy in 50 of 57 HR+ patients (88%). After 28 months median follow‐up, eight patients relapsed with the first site local in two, distant in five, and synchronous local/distant in one. No nodal recurrences were observed.ConclusionsSLN surgery for patients with LR post−mastectomy is feasible and informative. This approach appears oncologically sound, decreases axillary dissection rates and may be used to tailor adjuvant radiation target volumes and systemic therapies.
The Dubai Definition and Diagnostic Criteria of Laryngopharyngeal Reflux: The IFOS Consensus
Authors: Lechien Jerome R. , Vaezi Michael F. , Chan Walter W. , Allen Jacqueline E. , Karkos Petros D. , Saussez Sven , Altman Kenneth W. , Amin Milan R. , Ayad Tareck , Barillari Maria R. , Belafsky Peter C. , Blumin Joel H. , Johnston Nikki , Bobin Francois , Broadhurst Matthew , Ceccon Fabio P. , Calvo‐Henriquez Christian , Eun Young‐Gyu , Chiesa‐Estomba Carlos M. , Crevier‐Buchman Lise , Clarke John O. , Dapri Giovanni , Eckley Claudia A. , Finck Camille , Fisichella P. Marco , Hamdan Abdul‐Latif , Hans Stephane , Huet Kathy , Imamura Rui , Jobe Blair A. , Hoppo Toshitaka , Maron Lance P. , Muls Vinciane , O'Rourke Ashli K. , Perazzo Paulo S. , Postma Gregory , Prasad Vyas M.N. , Remacle Marc , Sant'Anna Geraldo D. , Sataloff Robert T. , Savarino Edoardo V. , Schindler Antonio , Siupsinskiene Nora , Tseng Ping‐Huei , Zalvan Craig H. , Zelenik Karol , Fraysse Bernard , Bock Jonathan M. , Akst Lee M. , Carroll Thomas L. 
Published: November 2023

ObjectiveThe objective of this work was to gather an international consensus group to propose a global definition and diagnostic approach of laryngopharyngeal reflux (LPR) to guide primary care and specialist physicians in the management of LPR.MethodsForty‐eight international experts (otolaryngologists, gastroenterologists, surgeons, and physiologists) were included in a modified Delphi process to revise 48 statements about definition, clinical presentation, and diagnostic approaches to LPR. Three voting rounds determined a consensus statement to be acceptable when 80% of experts agreed with a rating of at least 8/10. Votes were anonymous and the analyses of voting rounds were performed by an independent statistician.ResultsAfter the third round, 79.2% of statements (N = 38/48) were approved. LPR was defined as a disease of the upper aerodigestive tract resulting from the direct and/or indirect effects of gastroduodenal content reflux, inducing morphological and/or neurological changes in the upper aerodigestive tract. LPR is associated with recognized non‐specific laryngeal and extra‐laryngeal symptoms and signs that can be evaluated with validated patient‐reported outcome questionnaires and clinical instruments. The hypopharyngeal–esophageal multichannel intraluminal impedance–pH testing can suggest the diagnosis of LPR when there is >1 acid, weakly acid or nonacid hypopharyngeal reflux event in 24 h.ConclusionA global consensus definition for LPR is presented to improve detection and diagnosis of the disease for otolaryngologists, pulmonologists, gastroenterologists, surgeons, and primary care practitioners. The approved statements are offered to improve collaborative research by adopting common and validated diagnostic approaches to LPR.Level of Evidence5 Laryngoscope, 134:1614–1624, 2024
Patient Referral and Acceptance of Maxillomandibular Advancement for Obstructive Sleep Apnea
Authors: Rodin Julianna , Fiorella Michele , Crippen Meghan , Best Keisha , Taub Daniel , Champion Allen , Boon Maurits , Huntley Colin 
Published: November 2023

ObjectiveMaxillomandibular advancement (MMA) is an effective surgical treatment for obstructive sleep apnea (OSA); however, it is unclear how many patients who are referred for MMA actually undergo surgery. This study aims to determine follow‐up rates for patients referred for MMA and the reasons behind their choices.MethodsVia retrospective review, we assessed consecutive patients with OSA intolerant to continuous positive airway pressure (CPAP) who underwent drug induced sleep endoscopy (DISE) between 2018 and 2020 at our institution. Patients recommended for MMA based on DISE and other findings were included. Patients were then contacted and administered an IRB‐approved survey in present time.ResultsOne hundred and fifty nine patients were referred to oral maxillofacial surgery (OMFS) for MMA consult. Seventy seven patients (48%) followed up with OMFS and 29 (18%) underwent MMA. Sixty two (40%) patients resumed CPAP. Fifty eight patients (36.5%) were lost to follow up.Seventy three patients (46%) completed our survey. Of those patients, 37 (51%) followed up with OMFS and 17 (23%) underwent MMA. Patients who did not follow up with OMFS cited the invasiveness of the surgery (39%), recovery time (17%), or both (31%) as reasons. Those who pursued consultation cited inability to tolerate CPAP (73%), not being a candidate for inspire (14%), and desire to learn about alternative treatments (14%) as reasons. Of those who did not undergo MMA, 28.6% are not using OSA treatment.ConclusionLess than half of patients referred for MMA followed up, and less than half of those patients underwent MMA. Most patients cited concerns about the invasiveness of the surgery and recovery process.Level of Evidence4 Laryngoscope, 134:2964–2969, 2024
What is the impact of a multi‐component exercise intervention on the cure rate of urinary incontinence among older women living in the community?
Authors: Ricci Rachele , Avsar Pinar , Moore Zena , O'Connor Tom , Nugent Linda , Patton Declan 
Published: November 2023

AbstractAimsTo determine the impact of a multi‐component exercise intervention on the cure rate of urinary incontinence (UI) among older women living in the community.MethodA systematic search was conducted of five databases (Medline, Cumulative Index to Nursing and Allied Health Literature [CINAHL], Academic Search Complete, PubMed and Web of Science), grey literature and reference lists of relevant studies in December 2021– January 2022 and again between January 2023 and February 2023 when no additional new studies were identified. Key inclusion criteria were studies with female older adults above the age of 60, with any type of UI, residing in the community, addressing the effects of a multi‐component exercise intervention combining pelvic floor muscle training (PFMT), strength and balance exercises. The primary outcome of interest was the cure rate of UI in community‐dwelling older women (%).Studies underwent quality appraisal using the RevMan Risk of Bias tool and the Evidence‐based Librarianship tool, identifying significant biases. A narrative synthesis presents results for all outcomes; a meta‐analysis was also performed for secondary outcomes.ResultsFollowing the PRISMA 2020 guidelines, a total of 596 records were identified from the systematic search. Five studies met the inclusion criteria. Participants receiving the intervention had a statistically significant mean cure rate of 44.0% (p < 0.05), which decreased at follow‐up, except for participants with stress UI. Participants receiving the intervention had significantly decreased frequency of UI episodes (p < 0.00001) and increased maximum walking speed (p < 0.0003) at a 3‐month follow‐up.ConclusionA multi‐component exercise, combining PFMT, strength and balance exercises, is effective in improving and curing UI, especially stress UI, in community‐dwelling older women.
Long‐Read Sequencing Resolves a Complex Structural Variant in PRKN Parkinson's Disease
Authors: Daida Kensuke , Funayama Manabu , Billingsley Kimberley J. , Malik Laksh , Miano‐Burkhardt Abigail , Leonard Hampton L. , Makarious Mary B. , Iwaki Hirotaka , Ding Jinhui , Gibbs J. Raphael , Ishiguro Mayu , Yoshino Hiroyo , Ogaki Kotaro , Oyama Genko , Nishioka Kenya , Nonaka Risa , Akamatsu Wado , Blauwendraat Cornelis , Hattori Nobutaka 
Published: November 2023

AbstractBackgroundParkin RBR E3 ubiquitin‐protein ligase (PRKN) mutations are the most common cause of young onset and autosomal recessive Parkinson's disease (PD). PRKN is located in FRA6E, which is one of the common fragile sites in the human genome, making this region prone to structural variants. However, complex structural variants such as inversions of PRKN are seldom reported, suggesting that there are potentially unrevealed complex pathogenic PRKN structural variants.ObjectivesTo identify complex structural variants in PRKN using long‐read sequencing.MethodsWe investigated the genetic cause of monozygotic twins presenting with a young onset dystonia‐parkinsonism using targeted sequencing, whole exome sequencing, multiple ligation probe amplification, and long‐read sequencing. We assessed the presence and frequency of complex inversions overlapping PRKN using whole‐genome sequencing data of Accelerating Medicines Partnership Parkinson's disease (AMP‐PD) and United Kingdom (UK)‐Biobank datasets.ResultsMultiple ligation probe amplification identified a heterozygous exon three deletion in PRKN and long‐read sequencing identified a large novel inversion spanning over 7 Mb, including a large part of the coding DNA sequence of PRKN. We could diagnose the affected subjects as compound heterozygous carriers of PRKN. We analyzed whole genome sequencing data of 43,538 participants of the UK‐Biobank and 4941 participants of the AMP‐PD datasets. Nine inversions in the UK‐Biobank and two in AMP PD were identified and were considered potentially damaging and likely to affect PRKN expression.ConclusionsThis is the first report describing a large 7 Mb inversion involving breakpoints outside of PRKN. This study highlights the importance of using long‐read sequencing for structural variant analysis in unresolved young‐onset PD cases. © 2023 The Authors. Movement Disorders published by Wiley Periodicals LLC on behalf of International Parkinson and Movement Disorder Society. This article has been contributed to by U.S. Government employees and their work is in the public domain in the USA.
The effect of tube quality on externally calibrated quantitative nuclear magnetic resonance analysis: How bad can it be?
Authors: Ochoa Jessica L. , Germann Stephan , Conklin Breanna , Kurita Kenji , Russell David J. , Yang Cassie , Napolitano José G. 
Published: November 2023

AbstractExternally calibrated quantitative nuclear magnetic resonance (NMR) approaches offer practical means to simultaneously evaluate chemical identity and content without the addition of calibrants to the test sample. Despite continuous advances in external calibration over the last few decades, adoption of these approaches has been slower than expected. Variations in NMR tube geometry are a commonly overlooked factor that can have a substantial effect on externally calibrated quantitation methods. In this report, we investigate the extent to which tube‐to‐tube volume variability can affect quantitative NMR outcomes. The results highlight the importance of considering tube quality during the development stages of externally calibrated quantitative methods. In addition, we propose a simple, yet effective volume correction strategy using the residual protonated solvent signal that, based on experiments with mixed NMR tubes of varying quality, alleviates the effect of tube‐to‐tube variability.
Deep learning‐assisted preclinical MR fingerprinting for sub‐millimeter T1 and T2 mapping of entire macaque brain
Authors: Gu Yuning , Pan Yongsheng , Fang Zhenghan , Ma Lei , Zhu Yuran , Androjna Charlie , Zhong Kai , Yu Xin , Shen Dinggang 
Published: November 2023

AbstractPurposePreclinical MR fingerprinting (MRF) suffers from long acquisition time for organ‐level coverage due to demanding image resolution and limited undersampling capacity. This study aims to develop a deep learning‐assisted fast MRF framework for sub‐millimeter T1 and T2 mapping of entire macaque brain on a preclinical 9.4 T MR system.MethodsThree dimensional MRF images were reconstructed by singular value decomposition (SVD) compressed reconstruction. T1 and T2 mapping for each axial slice exploited a self‐attention assisted residual U‐Net to suppress aliasing‐induced quantification errors, and the transmit‐field (B1+) measurements for robustness against B1+ inhomogeneity. Supervised network training used MRF images simulated via virtual parametric maps and a desired undersampling scheme. This strategy bypassed the difficulties of acquiring fully sampled preclinical MRF data to guide network training. The proposed fast MRF framework was tested on experimental data acquired from ex vivo and in vivo macaque brains.ResultsThe trained network showed reasonable adaptability to experimental MRF images, enabling robust delineation of various T1 and T2 distributions in the brain tissues. Further, the proposed MRF framework outperformed several existing fast MRF methods in handling the aliasing artifacts and capturing detailed cerebral structures in the mapping results. Parametric mapping of entire macaque brain at nominal resolution of 0.35 0.35 1 mm3 can be realized via a 20‐min 3D MRF scan, which was sixfold faster than the baseline protocol.ConclusionIntroducing deep learning to MRF framework paves the way for efficient organ‐level high‐resolution quantitative MRI in preclinical applications.
Sustained pain and macrophage infiltration in a mouse muscle contusion model
Authors: Cortez Ibdanelo , Gaffney Caitlyn M. , Crelli Caitlin V. , Lee Eric , Nichols James M. , Pham Hoang Vu , Mehdi Syed , Janjic Jelena M. , Shepherd Andrew J. 
Published: November 2023

AbstractIntroduction/AimsPrior studies have emphasized the role of inflammation in the response to injury and muscle regeneration, but little emphasis has been placed on characterizing the relationship between innate inflammation, pain, and functional impairment. The aim of our study was to determine the contribution of innate immunity to prolonged pain following muscle contusion.MethodsWe developed a closed‐impact mouse model of muscle contusion and a macrophage‐targeted near‐infrared fluorescent nanoemulsion. Closed‐impact contusions were delivered to the lower left limb. Pain sensitivity, gait dysfunction, and inflammation were assessed in the days and weeks post‐contusion. Macrophage accumulation was imaged in vivo by injecting i.v. near‐infrared nanoemulsion.ResultsDespite hindpaw hypersensitivity persisting for several weeks, disruptions to gait and grip strength typically resolved within 10 days of injury. Using non‐invasive imaging and immunohistochemistry, we show that macrophage density peaks in and around the affected muscle 3 day post‐injury and quickly subsides. However, macrophage density in the ipsilateral sciatic nerve and dorsal root ganglia (DRG) increases more gradually and persists for at least 14 days.DiscussionIn this study, we demonstrate pain sensitivity is influenced by the degree of lower muscle contusion, without significant changes to gait and grip strength. This may be due to modulation of pain signaling by macrophage proliferation in the sciatic nerve, upstream from the site of injury. Our work suggests chronic pain developing from muscle contusion is driven by macrophage‐derived neuroinflammation in the peripheral nervous system.
Nonneurogenic female bladder outlet obstruction: Conservative and medical management
Authors: Perrin Andry , Corcos Jacques 
Published: November 2023

AbstractIntroductionIn nonneurogenic female bladder outlet obstruction (BOO), management goals include reduction of outlet resistance to increase urinary outflow and improve bladder voiding to prevent or reduce lower and upper urinary tract (LUT and UUT) function deterioration, by correcting the underlying etiology. As significant progress has been achieved in the conservative and pharmacological management of nonneurogenic female BOO, the purpose of this article is to review and summarize the current literature.Materials and MethodsFor this narrative review, a PubMed® search was performed by cross‐referencing the keywords “female bladder outlet obstruction,” “female voiding dysfunction,” “conservative management,” “pharmacological management,” and “treatment” with various terms related to the management of female BOO. Clinical practice guidelines and landmark reviews from the most renowned experts in the field were also used.ManagementThis review discusses and summarizes the conservative and pharmacological management of nonneurogenic female BOO based on the most relevant data currently available in the literature.ConclusionThe recent advances in the understanding of underlying mechanisms involved in female BOO allow for more individualized management. Conservative and pharmacological options show interesting outcomes, particularly in the context of a functional cause of BOO. Overall, the level of evidence is still low regarding the use of conservative and pharmacological measures and more long‐term data are required.
Actions matter more than words: From leader hypocrisy to employee withdrawal
Authors: Ilsev Arzu , Bayhan Karapinar Pinar , Metin Camgoz Selin 
Published: November 2023

AbstractLeader hypocrisy refers to perceptions of a leader's word–deed misalignment. This study explores the mechanisms underlying the relationship between leader hypocrisy and psychological withdrawal as an indicator of nonprofit employees' disengagement from work. We propose that leader hypocrisy indirectly relates to employees' psychological withdrawal behaviors by influencing the quality of their relationships (leader‐member exchange [LMX]) with their leaders. Within this mechanism, we differentiate two routes that can lead followers' perceptions of leader hypocrisy to LMX: trust in the leader and negative emotions. Data were gathered from 182 employees working in a variety of nonprofit organizations (NPOs) in two waves. The findings support the indirect effect of leader hypocrisy on psychological withdrawal through trust in the leader and LMX. However, the mediating effect of negative emotions was not supported as the direct path from negative emotions to LMX was not significant. By adding a direct path, the alternative model demonstrated that when employees perceive their leader as a hypocrite, negative emotions can directly create psychological withdrawal rather than influencing withdrawal through impairing relationship quality perceptions.