bluuebunny/crossref_metadata_2025_split huggingface dataset:
Implementing a nurse‐led screening clinic for symptom distress with community‐based referral for cancer survivors: A feasibility study
Authors: Lam Wendy Wing Tak , Ng Danielle W. L. , Fielding Richard , Sin Vivian , Tsang Catherine , Chan Wendy W. L. , Foo Chi Chung , Kwong Ava , Chan Karen K. L. 
Published: December 2023

AbstractIntroductionThis prospective, single‐arm, pragmatic implementation study evaluated the feasibility of a nurse‐led symptom‐screening program embedded in routine oncology post‐treatment outpatient clinics by assessing (1) the acceptance rate for symptom distress screening (SDS), (2) the prevalence of SDS cases, (3) the acceptance rate for community‐based psychosocial support services, and (4) the effect of referred psychosocial support services on reducing symptom distress.MethodsUsing the modified Edmonton Symptom Assessment System (ESAS‐r), we screened patients who recently completed cancer treatment. Patients screening positive for moderate‐to‐severe symptom distress were referred to a nurse‐led community‐based symptom‐management program involving stepped‐care symptom/psychosocial management interventions using a pre‐defined triage system. Reassessments were conducted at 3‐months and 9‐months thereafter. The primary outcomes included SDS acceptance rate, SDS case prevalence, intervention acceptance rate, and ESAS‐r score change over time.ResultsOverall, 2988/3742(80%) eligible patients consented to SDS, with 970(32%) reporting ≥1 ESAS‐r symptom as moderate‐to‐severe (caseness). All cases received psychoeducational material, 673/970(69%) accepted psychosocial support service referrals. Among 328 patients completing both reassessments, ESAS‐r scores improved significantly over time (p < 0.0001); 101(30.8%) of patients remained ESAS cases throughout the study, 112(34.1%) recovered at 3‐month post‐baseline, an additional 72(22%) recovered at 9‐month post‐baseline, while 43(12.2%) had resumed ESAS caseness at 9‐month post‐baseline.ConclusionNurse‐led SDS programs with well‐structured referral pathways to community‐based services and continued monitoring are feasible and acceptable in cancer patients and may help in reducing symptom distress. We intend next to develop optimal strategies for SDS implementation and referral within routine cancer care services.
Evaluation of the potential impact on pharmacokinetics of various cytochrome P450 substrates of increasing IL‐6 levels following administration of the T‐cell bispecific engager glofitamab
Authors: Djebli Nassim , Parrott Neil , Jaminion Felix , O'Jeanson Amaury , Guerini Elena , Carlile David 
Published: December 2023

AbstractGlofitamab is a novel T cell bispecific antibody developed for treatment of relapsed‐refractory diffuse large B cell lymphoma and other non‐Hodgkin's lymphoma indications. By simultaneously binding human CD20‐expressing tumor cells and CD3 on T cells, glofitamab induces tumor cell lysis, in addition to T‐cell activation, proliferation, and cytokine release. Here, we describe physiologically‐based pharmacokinetic (PBPK) modeling performed to assess the impact of glofitamab‐associated transient increases in interleukin 6 (IL‐6) on the pharmacokinetics of several cytochrome P450 (CYP) substrates. By refinement of a previously described IL‐6 model and inclusion of in vitro CYP suppression data for CYP3A4, CYP1A2, and 2C9, a PBPK model was established in Simcyp to capture the induced IL‐6 levels seen when glofitamab is administered at the intended dose and dosing regimen. Following model qualification, the PBPK model was used to predict the potential impact of CYP suppression on exposures of various CYP probe substrates. PBPK analysis predicted that, in the worst‐case, the transient elevation of IL‐6 would increase exposures of CYP3A4, CYP2C9, and CYP1A2 substrates by less than or equal to twofold. Increases for CYP3A4, CYP2C9, and CYP1A2 substrates were projected to be 1.75, 1.19, and 1.09‐fold following the first administration and 2.08, 1.28, and 1.49‐fold following repeated administrations. It is recommended that there are no restrictions on concomitant treatment with any other drugs. Consideration may be given for potential drug–drug interaction during the first cycle in patients who are receiving concomitant CYP substrates with a narrow therapeutic index via monitoring for toxicity or for drug concentrations.
Development of Physiologically Relevant Skin Organoids from Human Induced Pluripotent Stem Cells
Authors: Shafiee Abbas , Sun Jane , Ahmed Imaan A. , Phua Felicia , Rossi Gustavo R. , Lin Cheng‐Yu , Souza‐Fonseca‐Guimaraes Fernando , Wolvetang Ernst J. , Brown Jason , Khosrotehrani Kiarash 
Published: December 2023

AbstractThe development of skin organs for studying developmental pathways, modeling diseases, or regenerative medicine purposes is a major endeavor in the field. Human induced pluripotent stem cells (hiPSCs) are successfully used to derive skin cells, but the field is still far from meeting the goal of creating skin containing appendages, such as hair follicles and sweat glands. Here, the goal is to generate skin organoids (SKOs) from human skin fibroblast or placental CD34+ cell‐derived hiPSCs. With all three hiPSC lines, complex SKOs with stratified skin layers and pigmented hair follicles are generated with different efficacies. In addition, the hiPSC‐derived SKOs develop sebaceous glands, touch‐receptive Merkel cells, and more importantly eccrine sweat glands. Together, physiologically relevant skin organoids are developed by direct induction of embryoid body formation, along with simultaneous inactivation of transforming growth factor beta signaling, activation of fibroblast growth factor signaling, and inhibition of bone morphogenetic protein signaling pathways. The skin organoids created in this study can be used as valuable platforms for further research into human skin development, disease modeling, or reconstructive surgeries.
Platelet Membrane‐Derived Nanodiscs for Neutralization of Endogenous Autoantibodies and Exogenous Virulence Factors
Authors: Sun Lei , Yu Yiyan , Peng Yifei , Wang Dan , Wang Shuyan , Noh Ilkoo , Fang Ronnie H. , Gao Weiwei , Zhang Liangfang 
Published: December 2023

AbstractThe multifaceted functions of platelets in various physiological processes have long inspired the development of therapeutic nanoparticles that mimic specific platelet features for disease treatment. Here, the development and characterization of platelet membrane‐derived nanodiscs (PLT‐NDs) as platelet decoys for biological neutralization is reported. In one application, PLT‐NDs effectively bind with anti‐platelet autoantibodies, thus blocking them from interacting with platelets. In a mouse model of thrombocytopenia, PLT‐NDs successfully neutralize pathological anti‐platelet antibodies, preventing platelet depletion and maintaining hemostasis. In another application, PLT‐NDs effectively neutralize the cytotoxicity of bacterial virulence factors secreted by methicillin‐resistant Staphylococcus aureus (MRSA). In a mouse model of MRSA infection, treatment with PLT‐NDs leads to significant survival benefits for the infected mice. Additionally, PLT‐NDs show good biocompatibility and biosafety, as demonstrated in acute toxicity studies conducted in mice. These findings underscore the potential of PLT‐NDs as a promising platelet mimicry for neutralizing various biological agents that target platelets. Overall, this work expands the repertoire of platelet‐mimicking nanomedicine by creating a unique disc‐like nanostructure made of natural platelet membranes.
High‐Throughput Deposition of Recyclable SnO2 Electrodes toward Efficient Perovskite Solar Cells
Authors: Ling Xufeng , Guo Junjun , Shen Chengxia , Li Yiping , Tian Hongxing , Yuan Xiangbao , Gui Lin , Zhang Xuliang , Li Bin , Chen Shijian , Li Ru , Yuan Jianyu , Ma Wanli , Deng Yehao 
Published: December 2023

AbstractChemical bath deposited (CBD) SnO2 is one of the most prevailing electron transport layers for realizing high‐efficiency perovskite solar cells (PSCs) so far. However, the state‐of‐the‐art CBD SnO2 process is time‐consuming, contradictory to its prospect in industrialization. Herein, a simplified yet efficient method is developed for the fast deposition of SnO2 electrodes by incorporating a concentrated Sn source stabilized by the ethanol ligand with antimony (Sb) doping. The higher concentration of Sn source promotes the deposition rate, and Sb doping improves the hole‐blocking capability of the CBD SnO2 layer so that its target thickness can be reduced to further save the deposition time. As a result, the deposition time can be appreciably reduced from 3–4 h to only 5 min while maintaining 95% of the maximum efficiency, indicating the power of the method toward high‐throughput production of efficient PSCs. Additionally, the CBD SnO2 substrates are recyclable after removing the upper layers of complete PSCs, and the refurbished PSCs can maintain ≈98% of their initial efficiency after three recycling‐and‐fabrication processes.
Constraint Coupling of Redox Cascade and Electron Transfer Synchronization on Electrode‐Nanosensor Interface for Repeatable Detection of Tumor Biomarkers
Authors: Xie Xiyue , Jin Kaifei , Wang Zhenqiang , Wang Shuai , Zhu Jing , Huang Jixi , Tang Shuqi , Cai Kaiyong , Zhang Jixi 
Published: December 2023

AbstractQuantitative analysis of up‐regulated biomarkers in pathological tissues is helpful to tumor surgery yet the loss of biomarker extraction and time‐consuming operation limited the accurate and quick judgement in preoperative or intraoperative diagnosis. Herein, an immobilization‐free electrochemical sensing platform is developed by constraint coupling of electron transfer cascade on electrode‐nanosensor interface. Specifically, electrochemical indicator (Ri)‐labeled single‐stranded DNA on electroactive nanodonor (polydopamine, PDA) can be responsively detached by formation of DNA complex through the recognition and binding with targets. By applying the oxidation potential of Ri, nanosensor collisions on electrode surface trigger a cascade redox cycling of PDA and Ri through synchronous electron transfer, which boost the amplification of current signal output. The developed nanosensor exhibit excellent linear response toward up‐regulated biomarkers (miRNA‐21, ATP, and VEGF) with low detection limits (32 fM, 386 pM, and 2.8 pM). Moreover, background influence from physiological interferent is greatly reduced by restricted electron transfer coupling on electrode. The practical applicability is illustrated in sensitive and highly repeatable profiling of miRNA‐21 in lysate of tumor cells and tumor tissue, beneficial for more reliable diagnosis. This electrochemical platform by employing electron transfer cascades at heterogeneous interfaces offers a route to anti‐interference detection of biomarkers in tumor tissues.
Development of an effervescence‐assisted dispersive liquid phase microextraction using a binary solvent as a simultaneous extraction and preconcentration approach specialized for the analysis of pesticides in grape juice without dilution
Authors: Farajzadeh Mir Ali , Hoboobi Ali , Pezhhanfar Sakha , Mogaddam Mohammad Reza Afshar 
Published: December 2023

AbstractIn this study, a swift and economical extraction and preconcentration method called effervescence‐assisted dispersive liquid‐phase microextraction was developed to analyze the pesticide content of different grape juices. To propel the microextraction method, the sample was transferred to a conical bottom glass test tube, and ammonium chloride was added and vortexed to dissolve. Then, sodium bicarbonate and a mixture of 1,2‐dibromoethane and n‐hexane were added. The tube was located in a water bath and the produced carbon dioxide bubbles dispersed the extraction solvent into the sample. Finally, it was centrifuged and one microliter of the sedimented phase was injected into a gas chromatograph equipped with a flame ionization detector. Under the optimum conditions, the limits of detection and quantification ranged from 0.9 to 4.1 and 3.0 to 13.6 μg/L, respectively. Extraction recoveries and enrichment factors were achieved in the ranges of 36%–80% and 180%–404%, respectively. The inter‐ and intra‐day relative standard deviations were in the ranges of 3.4%–10.6% and 2.6%–9.7%, respectively. Also, the coefficients of determination in the calibration curves were ≥0.990. Short extraction time, no sorbent or costly apparatuses, using inexpensive chemicals, applying microliter levels of the extractant, and no dilution of the real samples are the highlights of the study.
The social connectivity of subsurface flows: Towards a better integration of the vertical dimension in socio‐hydrosystem studies
Authors: Boyer Anne‐Lise , Blanchon David , Schmitt Laurent , Badariotti Dominique , Bedell Jean‐Philippe , Beisel Jean‐Nicolas , Chabaux François , da Silva Eduardo Ferreira , Huneau Frédéric , Imfeld Gwenaël , O'Neill Brian F. , Pasqualini Vanina , Radakovitch Olivier , Staentzel Cybill , Le Tourneau François‐Michel 
Published: December 2023

AbstractThis contribution points out that while the importance of hydrologic, geomorphic, ecological, temporal, and socio‐cultural connectivity in the functioning of hydrosystems has been acknowledged in three dimensions (longitudinal, lateral, and vertical), vertical connectivity has often been overlooked. Drawing on a multidisciplinary literature review, the authors aim to highlight the socio‐cultural connectivity of subsurface flows and aquifers as a crucial factor for socio‐hydrosystem understanding and management. The piece builds on emergent literature which underscores how groundwater, shallow groundwater, and the hyporheic zone are coproduced by nature and society through time. Furthermore, the review explores how verticality has become an important heuristic dimension at the intersection of the environmental and social sciences, and there has been a particular focus on the hyporheic zone to look at how notions of interstitiality and (in)visibility can be better integrated with socio‐hydrosystem science and management. Finally, the paper calls for further research to integrate the vertical dimension of hydrosystems into more comprehensive socio‐hydrological frameworks, which remain, at times, empirically and theoretically weak on questions of social power, even if they do incorporate aspects of political systems. Especially as societies' relationships to groundwater may be at the heart of climate change adaptation strategies, greater consideration of the social connectivity to subflows is a necessary direction for sustainable water resource management and scholarship.This article is categorized under:
Human Water > Water Governance
Science of Water > Hydrological Processes
Science of Water > Water and Environmental Change
A call for an accurate presentation of glaciers as water resources
Authors: Gascoin Simon 
Published: December 2023

AbstractGlaciers are often portrayed as an important water resource in scientific research and public debate. However, the scientific literature calls for caution when presenting this idea. While melting glaciers can increase water insecurity, their contribution to runoff is often minor and other factors like excessive groundwater pumping for irrigation or surface and groundwater contamination pose much greater threats to water availability. As we consider the wide range of environmental impacts due to glacier changes, we must also question the “glacier as water resource” narrative that may unnecessarily contribute to public anxiety.This article is categorized under:
Human Water > Water as Imagined and Represented
Science of Water > Water and Environmental Change
Applying the Urban Scene as Community Practice Approach in the Field
Authors: Klekotko Marta 
Published: December 2023

AbstractThe chapter is based on extensive fieldwork carried out in three Polish cities and serves as an exemplification of the application of the approach proposed in Chapter 2 to the study of community phenomena in contemporary cities. Although based on Polish data, the research develops the universal concept of socio-cultural opportunity structures and thus allows to explain communal processes beyond national contexts. The chapter starts with a discussion on challenges in investigating social practices and provides the details of the applied methodology. Then, selected case studies of different scenes as community practices are presented and discussed in order to illustrate how urban space and cultural consumption practices interact, leading to the development of different kinds of communities, or rather community practices. From bohemian and alternative lifestyle communities, through ecologists and urban activists to local communities, the role of scene in community practices is presented and analysed.
$$ \mathcal{N} $$ = 2 JT supergravity and matrix models
Authors: Turiaci Gustavo J. , Witten Edward 
Published: December 2023

Abstract
Generalizing previous results for $$ \mathcal{N} $$
N
= 0 and $$ \mathcal{N} $$
N
= 1, we analyze $$ \mathcal{N} $$
N
= 2 JT supergravity on asymptotically AdS2 spaces with arbitrary topology and show that this theory of gravity is dual, in a holographic sense, to a certain random matrix ensemble in which supermultiplets of different R-charge are statistically independent and each is described by its own $$ \mathcal{N} $$
N
= 2 random matrix ensemble. We also analyze the case with a time-reversal symmetry, either commuting or anticommuting with the R-charge. In order to compare supergravity to random matrix theory, we develop an $$ \mathcal{N} $$
N
= 2 analog of the recursion relations for Weil-Petersson volumes originally discovered by Mirzakhani in the bosonic case.
Towards double parton distributions from first principles using Large Momentum Effective Theory
Authors: Jaarsma Max , Rahn Rudi , Waalewijn Wouter J. 
Published: December 2023

Abstract
In double parton scattering (DPS), two partonic collisions take place between one pair of colliding hadrons. The effect of DPS can be significant for precision measurements due to the additional radiation from secondary partonic collisions, and especially for specific processes such as same-sign WW production. Its effect is usually included through Monte Carlo parton showers. In a factorization approach to DPS, the initial state is described by double parton distributions (DPDs). These are currently poorly constrained by experiment, but provide a view on interesting correlations between partons in the hadron. Here we show that the Large Momentum Effective Theory approach can be applied to DPDs. Specifically, we present a general matching relation between DPDs and lattice-calculable quasi-DPDs for general flavor, spin and color structures. We furthermore calculate the one-loop matching coefficients for the quark-quark DPDs, verifying that the infrared logarithms and divergences cancel in the matching. While we restrict to the flavor-non-singlet case, we do take color and spin correlations into account. Interestingly, quasi-DPDs combines nontrivial features from both the collinear and transverse momentum dependent quasi-parton distribution functions. This represents a first step in extending the quasi-PDF approach to DPDs, opening up a new way to constrain these distributions using lattice QCD.
Linking Forest Ecosystem Services to the SDGs: Semi-quantitative Mapping of Perceptions towards Integrated Decision-making
Authors: Pham-Truffert Myriam , Pfund Jean-Laurent 
Published: December 2023

AbstractWith this study, we test and present the results of a reproducible semi-quantitative methodological approach, which enables us to map perceptions of complex systems, linking the forest ecosystem services (FES) of a given spatial level to the wider policy domains represented by the 2030 Agenda and its Sustainable Development Goals (SDGs). Through a participative process, we used integrated forest management and FES as entry point concepts to support and inform dialog towards a normative desired future as framed by the SDGs, taking into account interdependencies across sectors and policy domains. The scales used in the test were national (Switzerland) and international but it is possible to use the approach at any level of integration, especially the landscape one in the case of forest or other ecosystem issues to be transdisciplinary solved. We stress that the semi-quantitative aspects of the approach – be it the ranking of the importance of FES across the different SDGs, or the positive or negative weighting of interactions among these FES in cross-impact matrices – enable the perceptions held by actors to be more explicit and significant for governance or goal prioritization. The results illustrate the perceptions of selected actors on the effects of integrated forest management and provide a basis for multi-actor deliberation on emerging potential synergies or conflicts, thereby genuinely supporting science-policy-practice dialog, which is crucial to foster integrated decision-making.
Evaluation of stochastic flow lines with provisioning of auxiliary material
Authors: Helber Stefan , Kellenbrink Carolin , Südbeck Insa 
Published: December 2023

AbstractFlow lines are often used to perform assembly operations in multi-stage processes. During these assembly operations, components that are relatively small, compared to the work pieces travelling down the flow line, are mounted to the work pieces at a given stage. Those components, or more generally, any kind of auxiliary material, are provisioned to the corresponding production stage in a repetitive but not necessarily deterministic manner using a certain delivery frequency, each time filling the local storage up to a predetermined order-up-to level. Just like random processing times, machine failures, and repairs, the randomness of the provisioning process can impact the long-term throughput of such a flow line. In this paper, we develop a fast and accurate analytical performance evaluation method to estimate the long-term throughput of a Markovian flow line of this type for the practically important case of limited buffer capacities between the production stages. We first give an exact characterization of a two-machine line of that type and show how to determine system state probabilities and aggregate performance measures. Furthermore, we show how to use this two-machine model as the building block of an approximate decomposition approach for longer flow lines. As opposed to previous decomposition approaches, even the state space of the two-machine lines can become so large that an exact solution of the Markov chains can become impractical. We hence show how to set up, train, and use an artificial neural network to replace the Markov chain solver embedded in the decomposition approach, which then leads to an accurate and extremely fast flow line evaluation tool. The proposed methodology is evaluated by a comparison with simulation results and used to characterize the structural patterns describing the behaviour of flow lines of this type. The method can be used to systematically consider the combined impact of the delivery frequency and the local order-up-to levels for the auxiliary material when designing a flow line of this type.
New Route to Synthesize High-Entropy Carbide Powders by Mechanical Alloying
Authors: Idczak Rafał , Sobota Piotr , Tran Lan Maria , Babij Michał , Idczak Karolina , Nowak Wojciech , Pikul Adam 
Published: December 2023

AbstractA new route for the synthesis of the (NbTa)$$_{0.67}$$

0.67

(TiHfZr)$$_{0.33}$$

0.33

C and (NbTa)$$_{0.67}$$

0.67

(MoHfW)$$_{0.33}$$

0.33

C high-entropy carbides powders by mechanical alloying is presented. Namely, pure metal powders were wet-milled in toluene using a planetary mill under an argon atmosphere. The synthesized materials crystallize with a rock-salt structure (space group $$Fm{\bar{3}}m$$

F
m

3

¯

m

). A significant reduction in structural defects with annealing of the samples was detected with X-ray diffraction and positron annihilation experiments. Simultaneously, only simple metallic properties without any trace of magnetic or superconducting phase transitions were observed.