bluuebunny/crossref_metadata_2025_split huggingface dataset:
Mechanical-electrical-chemical coupling study on the stabilization of a hafnia-based ferroelectric phase
Authors: Bai Fenyun , Liao Jiajia , Yang Jiangheng , Jiang Yanping , Tang Xingui , Liu Qiuxiang , Tang Zhenhua , Zhou Yichun 
Published: December 2023

AbstractThe metastable polar orthorhombic phase is believed to be the origin of the ferroelectricity of hafnia-based films. The adjustment of stain, oxygen vacancies and dopant during film deposition and the wake-up electric cycling are common strategies to induce the ferroelectricity in hafnia. However, none of them could independently render the ferroelectric phase to be the most stable phase from the theoretical calculation results. The exact external conditions to stabilize orthorhombic phase still remain elusive. In this paper, we investigate the effects of the type, distribution, concentration, and charge state characteristics of oxygen vacancies and the uniaxial strain on the crystal’ energy, dielectric constant and spontaneous polarization (Ps); In addition, the impact of the applied electric field parallel to the Ps on the crystal’ energy is explored by first-principles calculations. It is challenging to independently stabilize the ferroelectric phase of hafnia-based films by a single component owing to the rather strict conditions. Surprisingly, the ferroelectricity can be easily obtained when simultaneously considering the effects of oxygen vacancies, uniaxial strain, and applied electric fields, suggesting the extremely important mechanical-electrical-chemical coupling effects. This work provides an explanation for the typical wake-up phenomenon in hafnia and a guidance for film applications.
Tislelizumab plus zanubrutinib for Richter transformation: the phase 2 RT1 trial
Authors: Al-Sawaf Othman , Ligtvoet Rudy , Robrecht Sandra , Stumpf Janina , Fink Anna-Maria , Tausch Eugen , Schneider Christof , Boettcher Sebastian , Mikusko Martin , Ritgen Matthias , Schetelig Johannes , von Tresckow Julia , Vehling-Kaiser Ursula , Gaska Tobias , Wendtner Clemens Martin , Chapuy Bjoern , Fischer Kirsten , Kreuzer Karl-Anton , Stilgenbauer Stephan , Staber Philipp , Niemann Carsten , Hallek Michael , Eichhorst Barbara 
Published: December 2023

AbstractIn patients with chronic lymphocytic leukemia, Richter transformation (RT) reflects the development of an aggressive lymphoma that is associated with poor response to chemotherapy and short survival. We initiated an international, investigator-initiated, prospective, open-label phase 2 study in which patients with RT received a combination of the PD-1 inhibitor tislelizumab plus the BTK inhibitor zanubrutinib for 12 cycles. Patients responding to treatment underwent maintenance treatment with both agents. The primary end point was overall response rate after six cycles. Of 59 enrolled patients, 48 patients received at least two cycles of treatment and comprised the analysis population according to the study protocol. The median observation time was 13.9 months, the median age was 67 (range 45–82) years. Ten patients (20.8%) had received previous RT-directed therapy. In total, 28 out of 48 patients responded to induction therapy with an overall response rate of 58.3% (95% confidence interval (CI) 43.2–72.4), including 9 (18.8%) complete reponse and 19 (39.6%) partial response, meeting the study’s primary end point by rejecting the predefined null hypothesis of 40% (P = 0.008). Secondary end points included duration of response, progression-free survival and overall survival. The median duration of response was not reached, the median progression-free survival was 10.0 months (95% CI 3.8–16.3). Median overall survival was not reached with a 12-month overall survival rate of 74.7% (95% CI 58.4–91.0). The most common adverse events were infections (18.0%), gastrointestinal disorders (13.0%) and hematological toxicities (11.4%). These data suggest that combined checkpoint and BTK inhibition by tislelizumab plus zanubrutinib is an effective and well-tolerated treatment strategy for patients with RT. ClinicalTrials.gov Identifier: NCT04271956.
Haplotype-resolved genome of heterozygous African cassava cultivar TMEB117 (Manihot esculenta)
Authors: Landi Michael , Shah Trushar , Falquet Laurent , Niazi Adnan , Stavolone Livia , Bongcam-Rudloff Erik , Gisel Andreas 
Published: December 2023

AbstractCassava (Manihot esculenta Crantz) is a vital tropical root crop providing essential dietary energy to over 800 million people in tropical and subtropical regions. As a climate-resilient crop, its significance grows as the human population expands. However, yield improvement faces challenges from biotic and abiotic stress and limited breeding. Advanced sequencing and assembly techniques enabled the generation of a highly accurate, nearly complete, haplotype-resolved genome of the African cassava cultivar TMEB117. It is the most accurate cassava genome sequence to date with a base-level accuracy of QV > 64, N50 > 35 Mbp, and 98.9% BUSCO completeness. Over 60% of the genome comprises repetitive elements. We predicted over 45,000 gene models for both haplotypes. This achievement offers valuable insights into the heterozygosity genome organization of the cassava genome, with improved accuracy, completeness, and phased genomes. Due to its high susceptibility to African Cassava Mosaic Virus (ACMV) infections compared to other cassava varieties, TMEB117 provides an ideal reference for studying virus resistance mechanisms, including epigenetic variations and smallRNA expressions.
The BrainLat project, a multimodal neuroimaging dataset of neurodegeneration from underrepresented backgrounds
Authors: Prado Pavel , Medel Vicente , Gonzalez-Gomez Raul , Sainz-Ballesteros Agustín , Vidal Victor , Santamaría-García Hernando , Moguilner Sebastian , Mejia Jhony , Slachevsky Andrea , Behrens Maria Isabel , Aguillon David , Lopera Francisco , Parra Mario A. , Matallana Diana , Maito Marcelo Adrián , Garcia Adolfo M. , Custodio Nilton , Funes Alberto Ávila , Piña-Escudero Stefanie , Birba Agustina , Fittipaldi Sol , Legaz Agustina , Ibañez Agustín 
Published: December 2023

AbstractThe Latin American Brain Health Institute (BrainLat) has released a unique multimodal neuroimaging dataset of 780 participants from Latin American. The dataset includes 530 patients with neurodegenerative diseases such as Alzheimer’s disease (AD), behavioral variant frontotemporal dementia (bvFTD), multiple sclerosis (MS), Parkinson’s disease (PD), and 250 healthy controls (HCs). This dataset (62.7 ± 9.5 years, age range 21–89 years) was collected through a multicentric effort across five Latin American countries to address the need for affordable, scalable, and available biomarkers in regions with larger inequities. The BrainLat is the first regional collection of clinical and cognitive assessments, anatomical magnetic resonance imaging (MRI), resting-state functional MRI (fMRI), diffusion-weighted MRI (DWI), and high density resting-state electroencephalography (EEG) in dementia patients. In addition, it includes demographic information about harmonized recruitment and assessment protocols. The dataset is publicly available to encourage further research and development of tools and health applications for neurodegeneration based on multimodal neuroimaging, promoting the assessment of regional variability and inclusion of underrepresented participants in research.
Condition-dependent survival and movement behavior in an endangered endemic damselfly
Authors: Mahdjoub Hayat , Zebsa Rabah , Kahalerras Amin , Amari Hichem , Bensouilah Soufyane , Samways Michael J. , Khelifa Rassim 
Published: December 2023

AbstractMovement is essential for the maintenance of populations in their natural habitats, particularly for threatened species living in fluctuating environments. Empirical evidence suggests that the probability and distance of movement in territorial species are context-dependent, often depending on population density and sex. Here, we investigate the movement behavior of the spring cohort of an endangered endemic damselfly Calopteryx exul in a lotic habitat of Northeast Algeria using capture-mark-recapture (CMR) of adults. By sampling 10 gridded river stretches across a 2 km section of the watercourse, we were able to estimate the distance of movement throughout individual lifespans and estimate movement probability for both males and females. We used multistate models to examine whether individual density and sex ratio influence survival and movement probability. We found that males and females had similar movement kernels with most individuals moving short distances (83% performing movements of < 100 m and only 1% > 1000 m). Of the 547 marked individuals, 63% were residents, and 37% were movers (moved at least 50 m from one sampling occasion to another). Survival probability showed higher estimates for females and was slightly density-dependent (i.e., lower survival probabilities were associated with high male densities). Survival probability did not show a marked difference between residents and movers. Movement probability and distances were positively correlated with individual density, but were not or slightly correlated with sex ratio, respectively. These results are not in line with the hypotheses of sex-biased movement and survival costs of movement. Our results suggest that the species performs mostly short-distance movements that are dependent on intraspecific interactions.
Gamma-glutamyl transferase and calculus of kidney incidence: a Mendelian randomization study
Authors: Li Peizhe , Pang Yuewen , He Shuang , Duan Junyao , Gong Huijie , Yan Yongji , Shi Jing 
Published: December 2023

AbstractElevated Gamma-glutamyl transferase (GGT) levels are often suggestive of cholelithiasis, and previous studies have indicated that GGT is highly expressed in the urinary system. Therefore, we hypothesized that there may be an association between GGT levels and calculus of kidney (CK) incidence. To investigate this potential causal relationship, we employed Mendelian randomization (MR) analysis. Additionally, we analyzed the levels of other liver enzymes, including alanine transaminase (ALT) and alkaline phosphatase (ALP). The relationship between GGT levels and CK incidence was analyzed using two-sample Mendelian randomization. Summary Genome-Wide Association Studies data were utilized for this analysis. 33 single nucleotide polymorphisms known to be associated with GGT levels were employed as instrumental variables. We employed several MR methods including IVW (inverse variance weighting), MR-Egger, weighted median, weighted mode, and MR-PRESSO (Mendelian Randomization Pleiotropy RESidual Sum and Outlier). Furthermore, we conducted tests for horizontal multivariate validity, heterogeneity, and performed leave-one-out analysis to ensure the stability of the results. Overall, several MR methods yielded statistically significant results with a p-value < 0.05. The results from the IVW analysis yielded an odds ratio (OR) of 1.0062 with a 95% confidence interval (CI) of 1.0016–1.0109 (p = 0.0077). Additional MR methods provided supplementary results: MR-Egger (OR 1.0167, 95% CI 1.0070–1.0266, p = 0.0040); weighted median (OR 1.0058, 95% CI 1.0002–1.0115, p = 0.0423); and weighted mode (OR 1.0083, 95% CI 1.0020–1.0146, p- = 0.0188). Sensitivity analyses did not reveal heterogeneity or outliers. Although potential horizontal pleiotropy emerged, we speculate that this could be attributed to inadequate test efficacy. However, subsequent use of MR-PRESSO did not provide evidence of pleiotropy. Our analysis suggests a positive association between elevated GGT levels and CK incidence, indicating an increased risk of CK development. However, no causal relationship was observed between levels of ALP or ALT and CK incidence.
Distant entanglement via photon hopping in a coupled cavity magnomechanical system
Authors: Sohail Amjad , Peng Jia-Xin , Hidki Abdelkader , Khalid Mohammad , Singh S. K. 
Published: December 2023

AbstractWe theoretically propose a scheme to generate distant bipartite entanglement between various subsystems in coupled magnomechanical systems where both the microwave cavities are coupled through single photon hopping coupling strength Γ. Each cavity contains a magnon mode and phonon mode and this gives six excitation modes in our model Hamiltonian which are cavity-1 photons, cavity-2 photons, magnon and phonon in cavity-1, and magnon and phonon in cavity-2. We found that significant bipartite entanglement exists between indirectly coupled subsystems in coupled microwave cavities for an appropriate set of parameters regime. Moreover, we also obtain suitable cavity and magnon detuning parameters for a significant distant bipartite entanglement in different bipartitions. In addition, it can be seen that a single photon hopping parameter significantly affects both the degree as well as the transfer of quantum entanglement between various bipartitions. Hence, our present study related to coupled microwave cavity magnomechanical configuration will open new perspectives in coherent control of various quantum correlations including quantum state transfer among macroscopic quantum systems.
Assessing the risk factors associated with sarcopenia in patients with liver cirrhosis: a case–control study
Authors: Xiao LeYao , Dai Mei , Zhao Fei , Shen YouShu , KWAN Rick Yiu Cho , Salvador Jordan Tovera , Zhang Li , Luo YaWen , Liu Qian , Yang Ping 
Published: December 2023

AbstractSarcopenia is a disease characterized by decreased muscle mass and strength, affecting 20–70% of patients with cirrhosis, and is associated with poor prognosis, complications, and high mortality. At present, the epidemiological investigation of sarcopenia in patients with liver cirrhosis is relatively limited, and because of the differences in population characteristics, regions, diagnostic criteria and diagnostic tools, the prevalence of sarcopenia in various studies varies greatly. The definition of sarcopenia in this study adopted the criteria of the Asian Working Group on Sarcopenia (AWGS 2019), including muscle mass and muscle strength / physical performance. A total of 271 patients with liver cirrhosis were included in this cross-sectional study to explore the influencing factors of sarcopenia in patients with liver cirrhosis. The prevalence of sarcopenia was 27.7%, 27.3% in male and 28.4% in female. The results of binary logistic regression analysis showed that age, physical activity, BMI, mid-upper arm muscle circumference, hepatic encephalopathy, nutritional status, alkaline phosphatase, albumin and total cholesterol were significantly correlated with the occurrence of sarcopenia in patients with liver cirrhosis. After adjusting for the potential influencing factors, it was found that the correlation between age and sarcopenia was weakened (OR = 0.870, 95% CI 0.338–2.239). The current findings show that sarcopenia is common in patients with cirrhosis and is independently associated with age, physical activity, BMI, nutritional status, and albumin, and serum alkaline phosphatase and total cholesterol are associated with the development of sarcopenia. Regular exercise may help maintain the grip strength of patients with cirrhosis and delay the deterioration of liver function.
Unravelling the impact of fat content on the microbial dynamics and spatial distribution of foodborne bacteria in tri-phasic viscoelastic 3D models
Authors: Purk Lisa , Kitsiou Melina , Ioannou Christina , El Kadri Hani , Costello Katherine M. , Gutierrez Merino Jorge , Klymenko Oleksiy , Velliou Eirini G. 
Published: December 2023

AbstractThe aim of the current study is to develop and characterise novel complex multi-phase in vitro 3D models, for advanced microbiological studies. More specifically, we enriched our previously developed bi-phasic polysaccharide (Xanthan Gum)/protein (Whey Protein) 3D model with a fat phase (Sunflower Oil) at various concentrations, i.e., 10%, 20%, 40% and 60% (v/v), for better mimicry of the structural and biochemical composition of real food products. Rheological, textural, and physicochemical analysis as well as advanced microscopy imaging (including spatial mapping of the fat droplet distribution) of the new tri-phasic 3D models revealed their similarity to industrial food products (especially cheese products). Furthermore, microbial growth experiments of foodborne bacteria, i.e., Listeria monocytogenes, Escherichia coli, Pseudomonas aeruginosa and Lactococcus lactis on the surface of the 3D models revealed very interesting results, regarding the growth dynamics and distribution of cells at colony level. More specifically, the size of the colonies formed on the surface of the 3D models, increased substantially for increasing fat concentrations, especially in mid- and late-exponential growth phases. Furthermore, colonies formed in proximity to fat were substantially larger as compared to the ones that were located far from the fat phase of the models. In terms of growth location, the majority of colonies were located on the protein/polysaccharide phase of the 3D models. All those differences at microscopic level, that can directly affect the bacterial response to decontamination treatments, were not captured by the macroscopic kinetics (growth dynamics), which were unaffected from changes in fat concentration. Our findings demonstrate the importance of developing structurally and biochemically complex 3D in vitro models (for closer proximity to industrial products), as well as the necessity of conducting multi-level microbial analyses, to better understand and predict the bacterial behaviour in relation to their biochemical and structural environment. Such studies in advanced 3D environments can assist a better/more accurate design of industrial antimicrobial processes, ultimately, improving food safety.
Application of Yang homotopy perturbation transform approach for solving multi-dimensional diffusion problems with time-fractional derivatives
Authors: Liu Jinxing , Nadeem Muhammad , Iambor Loredana Florentina 
Published: December 2023

AbstractIn this paper, we aim to present a powerful approach for the approximate results of multi-dimensional diffusion problems with time-fractional derivatives. The fractional order is considered in the view of the Caputo fractional derivative. In this analysis, we develop the idea of the Yang homotopy perturbation transform method (YHPTM), which is the combination of the Yang transform (YT) and the homotopy perturbation method (HPM). This robust scheme generates the solution in a series form that converges to the exact results after a few iterations. We show the graphical visuals in two-dimensional and three-dimensional to provide the accuracy of our developed scheme. Furthermore, we compute the graphical error to demonstrate the close-form analytical solution in the comparison of the exact solution. The obtained findings are promising and suitable for the solution of multi-dimensional diffusion problems with time-fractional derivatives. The main advantage is that our developed scheme does not require assumptions or restrictions on variables that ruin the actual problem. This scheme plays a significant role in finding the solution and overcoming the restriction of variables that may cause difficulty in modeling the problem.
Optimization and intelligent power management control for an autonomous hybrid wind turbine photovoltaic diesel generator with batteries
Authors: Rekioua D. , Mokrani Z. , Kakouche K. , Rekioua T. , Oubelaid A. , Logerais P. O. , Ali Enas , Bajaj Mohit , Berhanu Milkias , Ghoneim Sherif S. M. 
Published: December 2023

AbstractIn this paper, a critical issue related to power management control in autonomous hybrid systems is presented. Specifically, challenges in optimizing the performance of energy sources and backup systems are proposed, especially under conditions of heavy loads or low renewable energy output. The problem lies in the need for an efficient control mechanism that can enhance power availability while protecting and extending the lifespan of the various power sources in the system. Furthermore, it is necessary to adapt the system's operations to variations in climatic conditions for sustained effectiveness. To address the identified problem. It is proposed the use of an intelligent power management control (IPMC) system employing fuzzy logic control (FLC). The IPMC is designed to optimize the performance of energy sources and backup systems. It aims to predict and adjust the system's operating processes based on variations in climatic conditions, providing a dynamic and adaptive control strategy. The integration of FLC is specifically emphasized for its effectiveness in balancing multiple power sources and ensuring a steady and secure operation of the system. The proposed IPMC with FLC offers several advantages over existing strategies. Firstly, it showcases enhanced power availability, particularly under challenging conditions such as heavy loads or low renewable energy output. Secondly, the system protects and extends the lifespan of the power sources, contributing to long-term sustainability. The dynamic adaptation to climatic variations adds a layer of resilience to the system, making it well-suited for diverse geographical and climatic conditions. The use of realistic data and simulations in MATLAB/Simulink, along with real-time findings from the RT-LAB simulator, indicates the reliability and practical applicability of the proposed IPMC strategy. Efficient load supply and preserved batteries further underscore the benefits of the fuzzy logic-based control strategy in achieving a well-balanced and secure system operation.
Magnetized radiative flow of propylene glycol with carbon nanotubes and activation energy
Authors: Ali Ghazwani Hassan , Saleem Muzher , Haq Fazal 
Published: December 2023

AbstractCarbon nanotubes (CNTs) have gained significant attention in the field of fluid dynamics and fluid flows due to their unique properties and the potential to enhance various aspects of fluid transport features. This article explores the behavior of Darcy–Forchheimer flow of Propylene glycol $$\left( {C_{3} H_{8} O_{2} } \right)$$

C
3

H
8

O
2

submerged single wall carbon nanotubes (SWCNT) and multi-wall carbon nanotubes (MWCNT). The flow features are examined over stretched preamble surface of sheet. Energy relation is acquired in manifestation of thermal radiation and Joule heating. Aspects of Arrhenius kinetics and chemical reaction are assimilated in mass transport relation. Furthermore, effects of intermolecular fluid friction is accounted. Flow prevailing mathematical model is acquired by implementing boundary layer assumptions. Transformations procedure is adapted to alter the dimensional model into non-dimensional one and then tackled through Runge–Kutta–Fehlberg method (RKF-45) in Mathematica. Effective consequences of influential flow controlling parameters on fluid velocity, thermal transport and concentration are inspected by plotting. Numerical computations for interesting engineering quantities like skin friction coefficient, mass and heat transfer rates are tabulated and investigated. It is noticed that thermal field boosts versus curvature variable, Eckert and Hartmann numbers. Retardation in mass concentration is noticed via Schmidt number and activation energy variable. Velocity field shows decreasing trend through porosity parameter, Hartmann number and Darcy–Forchheimer variable. Furthermore, it is noticed that magnitude of skin friction coefficient is higher for SWCNT as compared to MWCNT.