bluuebunny/crossref_metadata_2025_split huggingface dataset:
Prognoses of Patients Treated With Surgical Therapy Versus Continuation of Local-Plus-Systemic Therapy Following Successful Down-Staging of Intermediate-Advanced Hepatocellular Carcinoma: A Multicenter Real-World Study
Authors: Liu Jianwei , Zhu Xiaodong , Pan Yangxun , Zhong Jianhong , Jin Renan , Zheng Xin , Zhang Wei , Hu Kuan , Ma Jian , Shi Xiaoyi , Liu Hongzhi , Yang Xiaobo , Xu Da , Ma Chi , Chen Jiangming , Wang Dongxu , Wang Xiaojun , Li Zhongchao , Zhao Lei , Zhang Leida , Li Tao , Liu Fubao , Tan Guang , Xing Baocai , Zhao Haitao , Zeng Yongyi , Zhang Shuijun , Zhang Lei , Zhou Ledu , Song Tianqiang , Yang Wei , Liang Xiao , Xiang Bangde , Xu Li , Sun Huichuan , Wang Kui 
Published: October 2023

Abstract

Background
The difference in the prognoses between treatment with surgical therapy and continuation of local-plus-systemic therapy following successful down-staging of intermediate-advanced hepatocellular carcinoma (HCC) remains unclear.

Methods
Data of 405 patients with intermediate-advanced HCC treated at 30 hospitals across China from January 2017 to July 2022 were retrospectively reviewed. All patients received local-plus-systemic therapy and were divided into the surgical (n = 100) and nonsurgical groups (n = 305) according to whether they received surgical therapy. The differences between long-term prognoses of the 2 groups were compared. Subgroup analysis was performed in 173 HCC patients who met the criteria for surgical resection following down-staging.

Results
Multivariable analysis of all patients showed that surgical therapy, hazard ratio (HR): 0.289, 95% confidence interval, CI, 0.136-0.613) was a protective factor for overall survival (OS), but not for event-free survival (EFS). Multivariable analysis of 173 intermediate-advanced HCC patients who met the criteria for surgical resection after conversion therapy showed that surgical therapy (HR: 0.282, 95% CI, 0.121-0.655) was a protective factor for OS, but not for EFS. Similar results were obtained after propensity score matching. For patients with Barcelona Clinic Liver Cancer stage B (HR: 0.171, 95% CI, 0.039-0.751) and C (HR: 0.269, 95% CI, 0.085-0.854), surgical therapy was also a protective factor for OS.

Conclusions
Overall, for patients with intermediate-advanced HCC who underwent local-plus-systemic therapies, surgical therapy is a protective factor for long-term prognosis and can prolong OS, and for those who met the surgical resection criteria after conversion therapy, surgical therapy is recommended.
Introduction: Looking
Authors: Reynolds Paige 
Published: October 2023

AbstractOpening with a close reading of Sally Rooney’s Beautiful World, Where Are You (2021), this introduction offers a new history of Irish women’s writing, exposing the critical biases that have occluded our understanding of its intricate relationship with literary modernism. It also lays out the conceptual framework for the stubborn mode of modernism. Stubborn modes are tried-and-true literary tactics that trigger a sense of recognition when readers encounter them, a constellation of traits—including style, tone, forms, content, and history—commonly associated with a particular literary movement or school that travels across time. Composed of literary conventions, the stubborn mode of modernism sustains the aesthetic as well as the political impulses associated with the movement’s early history. The stubborn mode in contemporary fiction helps to remind readers of the sweep of history, using literary form and content to underscore certain ongoing cultural problems, as well as to call attention to remedies previously imagined for such stubborn problems, whether the outcomes of those interventions have proven to be successful, unsuccessful, or (more likely, as seen across time) a measure of both.
Refashioning Modernism
Authors: Reynolds Paige 
Published: October 2023

AbstractThis chapter turns to short fiction by Irish women writers, skipping across decades to examine the ongoing tactical use of the stubborn mode of modernism in representations of female subjectivity. Elizabeth Bowen’s “Summer Night” (1941), set during Irish neutrality of the Second World War, Maeve Kelly’s “Morning at My Window” (1972) and Evelyn Conlon’s “Taking Scarlet as a Real Colour or And Also, Susan …” (1993), both written in the midst of specific moments of feminist urgency for Irish women, and June Caldwell’s “SOMAT” (2015), published amid the abortion rights debates that preceded the repeal of the Eight Amendment of the Irish Constitution, demonstrate how women writing in the aftermath of high modernism repurpose its experiments, seeking in part to amend the early movement’s masculinist bias. In their representations of neglected aspects of female subjectivity, they engage with modernist heavyweights such as Joyce and Eliot, but they also mine Russian theater and popular romance, among other surprising sources.
Logging Off
Authors: Reynolds Paige 
Published: October 2023

AbstractThis chapter examines the acceleration of time and the tsunami of information available due to new media technologies, looking at how Irish women contemporary writers represent “logging off” in pursuit of slow time and privacy. Novels such as Éilís Ní Dhuibhne’s The Dancers Dancing (1999) and Claire-Louise Bennett’s Pond (2015) use the modernist mode, including strategies adopted and adapted from the short fiction of Katherine Mansfield and the prose poems of Gertrude Stein, respectively, to represent female characters who retreat to rural sites and evade the incursions of modernity and technology on their private lives. In dramatic contrast, Louise O’Neill’s dystopian young adult novel Only Ever Yours (2014) concocts an environmentally devastated and technologically managed Ireland that allows women no privacy at all.
Reading
Authors: Reynolds Paige 
Published: October 2023

AbstractThe critical and commercial success of Sally Rooney’s Normal People (2018) and Anna Burns’s Milkman (2018) exposes the logics that invite Irish women’s writing to enter mainstream conversations, but preclude it from fully inhabiting them. These novels, making use of the modernist mode in their depictions of different historical settings, provocatively identify intransigent problems encountered by women, even those alert to possible freedoms of the global present. They focus in particular on the act of reading to underscore the complex if familiar brew of liberties and limitations that inform the lives of women, even today, in the Republic and Northern Ireland. This attention to reading elucidates the changing textures of female privacy in a way that speaks powerfully to young adults in the humanities classroom and provides a valuable example of the ethics of the stubborn mode at work in the present day.
Coat protein of cassava common mosaic virus targets RAV1 and RAV2 transcription factors to subvert immunity in cassava
Authors: Wei Yunxie , Xie Haoqi , Xu Lulu , Cheng Xiao , Zhu Binbin , Zeng Hongqiu , Shi Haitao 
Published: October 2023

Abstract
Cassava common mosaic virus (CsCMV, genus Potexvirus) is a prevalent virus associated with cassava mosaic disease, so it is essential to elucidate the underlying molecular mechanisms of the coevolutionary arms race between viral pathogenesis and the cassava (Manihot esculenta Crantz) defense response. However, the molecular mechanism underlying CsCMV infection is largely unclear. Here, we revealed that coat protein (CP) acts as a major pathogenicity determinant of CsCMV via a mutant infectious clone. Moreover, we identified the target proteins of CP-related to abscisic acid insensitive3 (ABI3)/viviparous1 (VP1) (MeRAV1) and MeRAV2 transcription factors, which positively regulated disease resistance against CsCMV via transcriptional activation of melatonin biosynthetic genes (tryptophan decarboxylase 2 (MeTDC2), tryptamine 5-hydroxylase (MeT5H), N-aceylserotonin O-methyltransferase 1 (MeASMT1)) and MeCatalase6 (MeCAT6) and MeCAT7. Notably, the interaction between CP, MeRAV1, and MeRAV2 interfered with the protein phosphorylation of MeRAV1 and MeRAV2 individually at Ser45 and Ser44 by the protein kinase, thereby weakening the transcriptional activation activity of MeRAV1 and MeRAV2 on melatonin biosynthetic genes, MeCAT6 and MeCAT7 dependent on the protein phosphorylation of MeRAV1 and MeRAV2. Taken together, the identification of the CP-MeRAV1 and CP-MeRAV2 interaction module not only illustrates a molecular mechanism by which CsCMV orchestrates the host defense system to benefit its infection and development but also provides a gene network with potential value for the genetic improvement of cassava disease resistance.
Jaw claudication and jaw stiffness in giant cell arteritis: secondary analysis of a qualitative research dataset
Authors: Lim Joyce , Dures Emma , Bailey Lawrence F , Almeida Celia , Ruediger Carlee , Hill Catherine L , Robson Joanna C , Mackie Sarah L 
Published: October 2023

Abstract

Objective
Jaw symptoms can be a vital clue to the diagnosis of GCA. Guidelines recommend more intensive treatment if jaw claudication is present. We sought to explore how patients with GCA described their jaw symptoms.

Methods
We carried out a secondary, qualitative analysis of interview data from 36 participants from the UK (n = 25) and Australia (n = 11), originally collected in order to develop a patient-reported outcome measure for GCA. In all cases, GCA had been confirmed by biopsy/imaging. Interview transcripts were organized within QSR NVivo 12 software and analysed using template analysis. Themes were refined through discussion among the research team, including a patient partner.

Results
Twenty of 36 participants reported jaw symptoms associated with GCA. The median age of these 20 participants was 76.5 years; 60% were female. Five themes were identified: physical sensations; impact on function; impact on diet; symptom response with CSs; and attribution to other causes. Physical sensations included ache, cramp, stiffness and ‘lockjaw’. Functional impacts included difficulty in eating/chewing, cleaning teeth, speaking or opening the mouth. Dietary impacts included switching to softer food. Response to CSs was not always immediate. Jaw symptoms were initially mis-attributed by some participants to arthritis, age or viral illnesses; or by health-care professionals to a dental cavity, ear infection or teeth-grinding.

Conclusion
Jaw symptoms in GCA are diverse and can lead to diagnostic confusion with primary temporomandibular joint disorder, potentially contributing to delay in GCA diagnosis. Further research is needed to determine the relationship of jaw stiffness to jaw claudication.
How is the patient perspective captured in ANCA-associated vasculitis research? An integrative review
Authors: Granath Annika , Pettersson Susanne , Gunnarsson Iva , Welin Elisabet , Dahlberg Karuna 
Published: October 2023

Abstract

Objective
The aim was to describe how the patient perspective is captured in clinical research on ANCA-associated vasculitis (AAV).

Methods
This integrative review included 2149 publications found in four different databases and manual searches. After screening, 156 articles remained. All articles were sorted and categorized, and 77 original articles were analysed further.

Results
The patient perspective was captured with patient-reported outcome measures (PROMs), single-item questionnaires, project-specific questionnaires and interviews. The most common aspects measured were health-related quality of life, anxiety and depression, and fatigue, and the least common were lifestyle habits, relationships and self-management.

Conclusion
The patient perspective was captured predominantly with generic PROMs and occasionally with a qualitative approach. AVV is a lifelong disease, and the results from this review show that not all aspects of importance to patients are covered with the PROMs used in research. Future studies should include the areas that are the most important for patients.
Detailed integrative taxonomic analysis reveals large-scale species misidentification of barnacles based on DNA barcoding data
Authors: Moesges Zoe , Brandis Dirk , Ewers Christine 
Published: October 2023

Abstract
Morphological species identification is the traditional way to identify species. More recently, biodiversity studies have depended on DNA barcoding for species identification. Mismatches between morphological and genetic species identification caused by voucher specimen misidentifications lead to ambiguous species identification. We used barnacles of the genera Amphibalanus and Balanus to investigate this issue. The purpose of this study was to assess the accuracy of the Barcoding of Life database and determine the true species affinity of three inconsistent barnacle barcode index numbers using an integrative taxonomic approach. To this end, we re-identified barcoded voucher specimens, or we identified specimens based on a dichotomous key that we barcoded subsequently. We found that 75% of Barcoding of Life clades representing genetic species showed inconsistent species assignments. One clade (BOLD: AAG0069), containing mostly unidentified Balanus sp. individuals, was morphologically and genetically Balanus balanus (Linneaus, 1758); a second clade (BOLD: AAB1410), containing specimens mostly identified as B. balanus, turned out to be morphologically and genetically Balanus crenatus Bruguière, 1789; and a third clade (BOLD: AAE2482), containing different species of Amphibalanus, was Amphibalanus improvisus (Darwin, 1854). This study showed that morphological species identification and taxonomic expertise can resolve the widespread misidentification in barcoding data. To prevent this problem in the future, morphological taxonomy and molecular species identification need to interact more closely.
CLINICAL OUTCOMES OF RHEGMATOGENOUS RETINAL DETACHMENT REPAIR IN PATIENTS WITH NYSTAGMUS
Authors: Torjani Ava , Shahlaee Abtin , Salabati Mirataollah , Mahmoudzadeh Raziyeh , Klufas Michael A. 
Published: October 2023

Purpose:
To report the anatomical and visual outcomes of rhegmatogenous retinal detachment repair in patients with congenital or acquired nystagmus.

Methods:
This was a case series involving a retrospective review of medical records from January 1, 2015, to April 1, 2021, of eight eyes of eight patients (seven men and one woman) with documented nystagmus who underwent rhegmatogenous retinal detachment repair. Primary outcomes included final reattachment rate and single surgery anatomical success at three months postoperatively. Secondary outcomes included final visual acuity and mean number of additional procedures required for retinal reattachment.

Results:
Mean age was 52.1 years (range: 14–77 years), and mean follow-up time was 18.6 months (range: 2.8–32.9 months). Pars plana vitrectomy (PPV) was performed in four patients (50.0%), scleral buckle in 3 (37.5%), and PPV/scleral buckle in 1 (12.5%). A repeat PPV was required in three eyes (37.5%) because of proliferative vitreoretinopathy, two of which initially underwent PPV, and one had PPV/scleral buckle. Two eyes (25%) required a third PPV because of proliferative vitreoretinopathy or retinal breaks. Mean time to first redetachment was 29 days. Single surgery anatomic success at three months was achieved in five patients (62.5%). Complete final retinal reattachment was achieved in all patients. Final visual acuity improved or stabilized in seven eyes (87.5%).

Conclusion:
Despite a 100% final retinal reattachment rate, rhegmatogenous retinal detachment repair can be challenging among patients with nystagmus, including postoperative complications such as recurrent retinal detachment because of retinal breaks. No silicone oil emulsification or related complications were observed in our series.
Long-chain n-3 polyunsaturated fatty acids for the management of age- and disease-related declines in skeletal muscle mass, strength and physical function
Authors: Phillips Nathan , Gray Stuart R. , Combet Emilie , Witard Oliver C. 
Published: October 2023

Purpose of review
This review uses the hierarchy of evidence as a framework to critically evaluate the effect of long chain n-3 polyunsaturated fatty acid (LCn-3 PUFA) ingestion alone, or as an adjunctive intervention to resistance training, on muscle health-related outcomes in healthy and clinical older adult populations.

Recent findings
Systematic reviews and meta-analyses of randomized controlled trials consistently report small, but clinically-relevant, effects of LCn-3 PUFA ingestion on strength outcomes, whereas mixed findings have been reported regarding changes in muscle mass and physical function. Cohort studies indicate an association between higher dietary LCn-3 PUFA intake and reduced likelihood of a sarcopenia diagnosis. Acute metabolic studies provide limited evidence for an effect of LCn-3 PUFA ingestion alone, or in combination with resistance training, on free-living integrated rates of MPS, static markers of muscle protein breakdown, or satellite cell activation in healthy older adults.

Summary
Recent data supports the efficacy of LCn-3 PUFA ingestion to facilitate small, but clinically relevant, improvements in muscle strength in healthy and clinical older adult populations. The mechanism(s) that underpin the action of LCn-3 PUFA in promoting strength outcomes remain unknown, but likely relate to neuromuscular function.
Correlates of Past Childhood Homelessness in a Nationally Representative Sample of US Adults
Authors: Bommersbach Tanner J. , Rhee Taeho Greg , Zhou Bin , Rosenheck Robert 
Published: October 2023

Abstract
Limited empirical data have been available on the adult sequelae of childhood homelessness. Using nationally representative data from the National Epidemiologic Survey of Alcohol and Related Conditions-III, we compared a hierarchy of adults who were never homeless, those who were only homeless as children, and those who were homeless both as children and adults, hypothesizing greater adversity as one moved up the three-level hierarchy on sociodemographic, behavioral, and lifetime mental health diagnostic characteristics. As a further evaluation of the status of adults who were homeless as both children and adults, we compared this highest risk group to those who had been homeless only as adults. Individuals who experienced childhood homelessness were 46.9 times more likely than others to also experience adult homelessness. Testing the hierarchical hypothesis, compared with those who were never homeless, individuals who experienced homelessness only as children reported numerous associated disadvantages, including childhood sexual abuse/neglect, parental adversities, adult incarceration, psychiatric disorders, and low academic achievement/employment. Those reporting both child and adult homelessness, in contrast to childhood homelessness alone, additionally met the criteria for multiple substance use disorders, confirming our hierarchical hypothesis. Those reporting both child and adult homelessness also showed more numerous social and psychiatric problems when compared with those experiencing homelessness for the first time as adults. This study demonstrates how homelessness in childhood is associated with extensive social and psychiatric adversities in both childhood and adulthood.
Using Public Health Detailing to Increase Access and Confidence in COVID-19 Vaccines and Reinvest in Disproportionately Impacted NYC Communities
Authors: Shabbat Nina , Dresser Michelle G. , Petrsoric Lysa J. , Bhatnagar Ansari Avani , Morse Michelle E. 
Published: October 2023

Context:
COVID-19 vaccination rates in New York City (NYC) began to plateau in the spring of 2021, with unacceptable inequities in vaccination rates based on race.

Program:
To address racial inequities in vaccination rates and COVID-19 health outcomes, the New York City Department of Health and Mental Hygiene adapted a preexisting provider outreach and education program for public health emergency use with the goals of community reinvestment and increasing patient confidence and access to the COVID-19 vaccines. The Vaccine Public Health Detailing (VPHD) program was delivered as part of a larger community outreach initiative and brought timely updates, materials, and access to technical assistance to primary care providers and staff in NYC neighborhoods experiencing COVID-19 health inequities. Outreach representatives also collected feedback from providers on resource needs to inform the agency's response.

Implementation:
Sixteen outreach representatives were rapidly trained on COVID-19–related content and strategic communication techniques and launched a 3-wave campaign across targeted neighborhoods throughout NYC. The campaign ran from May 2021 to March 2022 and was conducted in coordination with other community engagement initiatives aimed at the general public to promote greater collective impact.

Evaluation:
In total, 2873 detailing sessions were conducted with 2027 unique providers at 1281 sites. Outreach representatives successfully completed visits at more than 85% of practices that were in scope and operating. Approximately 20% (285) of the sites requested a referral for technical assistance to become a COVID-19 vaccination site or enroll in the Citywide Immunization Registry. Qualitative information shared by providers offered a more in-depth understanding of vaccine-related sentiments and challenges faced by providers on the ground.

Discussion:
VPHD is an effective method for supporting community providers, gathering feedback on resource needs and practice challenges, and increasing health systems efficacy during a public health emergency while also prioritizing racial equity and community reinvestment.
Stack versus Te Technique for Central Slip Reconstruction during Vascularized Toe Proximal Interphalangeal Joint Transfer
Authors: Peng Chi , Lee Che-Hsiung , Chen Shih-Heng , Huang Ren-Wen , Hsu Chung-Cheng , Lin Cheng-Hung , Lin Yu-Te 
Published: October 2023

Background:
Significant extension deficit is a common problem after a vascularized toe proximal interphalangeal joint transfer. One of the main causes related to extensor lag is central slip deficiency of the donor toes. In their clinical practice, the authors performed both the Stack and Te techniques to reconstruct central slip function during a joint transfer. The aim of this study was to compare the long-term outcomes of vascularized joint transfers between these two techniques.

Methods:
From May of 2009 to October of 2021, 38 digits in 36 patients (28 men and 8 women) underwent free vascularized toe joint transfer requiring central slip reconstruction. Eight and 30 digits were reconstructed with the Stack technique and the Te technique, respectively.

Results:
The median length of follow-up was 19 months (range, 5 to 78 months). The overall median extension lag was 20 ± 20 degrees and flexion was 80 ± 20 degrees. There were no significant differences in extension lag (25 ± 29 degrees versus 20 ± 15 degrees; P = 0.281), flexion (75 ± 10 degrees versus 85 ± 20 degrees; p = 0.13), or range of motion (53 ± 23 degrees versus 63 ± 15 degrees; P = 0.076) of the joints between the Stack and Te techniques after the transfers.

Conclusions:
From the limited number of cases, both the Stack and Te techniques provided similar outcomes in correcting extension lag in vascularized joint transfers. The Te technique is a simplified and effective method for central slip reconstruction, whereas caution is advised when using the Stack technique because of potential complications.

CLINICAL QUESTION/LEVEL OF EVIDENCE:
Therapeutic, III.