bluuebunny/crossref_metadata_2025_split huggingface dataset:
Phase 2 study of ibrutinib plus venetoclax in Japanese patients with relapsed/refractory mantle cell lymphoma
Authors: Goto Hideki , Ito Satoshi , Kizaki Masahiro , Yamaguchi Masaki , Fukuhara Noriko , Kato Koji , Saito Toko , Terui Yasuhito , Okubo Sumiko , Soshin Tomomi , Zeng Jiewei , Honda Hideyuki , Badawi Mohamed , Ross Jeremy A. , Izutsu Koji 
Published: December 2023

Abstract
Background
Despite high response rates to initial therapy, most patients with mantle cell lymphoma (MCL) experience relapsed or refractory (R/R) disease. Here, we report the efficacy, safety, and pharmacokinetics of the Phase 2, single-arm M20-075 study (NCT04477486) of ibrutinib and venetoclax combination therapy in Japanese patients with R/R MCL.

Methods
Patients received 560 mg ibrutinib and 400 mg venetoclax (after a 5-week ramp-up from 20 mg) once daily for up to 104 weeks. Primary endpoint was complete response (CR) rate by independent review committee (IRC). Secondary endpoints included overall response rate (ORR), duration of response (DOR), undetectable minimal residual disease (uMRD) rate, progression-free survival (PFS), overall survival (OS), safety including dose-limiting toxicity (DLT) assessment in the first six patients, and pharmacokinetic parameters. Full analysis set (FAS) comprised all treated patients. Per protocol set (PPS) excluded treated patients with non-evaluable disease at baseline by IRC.

Results
Thirteen patients were treated (FAS n = 13; PPS, n = 12). Median age was 71 years, patients had a median of two prior treatments. After a median follow-up of 9.6 months, IRC-assessed CR rate and ORR were both 83% (PPS). All six MRD-evaluable patients had uMRD. Median DOR, PFS, and OS were unreached. The most common Grade ≥ 3 treatment-emergent adverse event (TEAE) was neutropenia (23%); 1 patient discontinued due to squamous cell carcinoma of the lung. No DLTs, tumor lysis syndrome, or deaths related to TEAEs were observed.

Conclusion
Ibrutinib plus venetoclax exhibited high response rates and a well-tolerated safety profile in Japanese patients with R/R MCL.
Intersectional coalitions towards a just agroecology: weaving mutual aid and agroecology in Barcelona and Seville
Authors: Facchini Francesco , López-García Daniel , Villamayor-Tomas Sergio , Corbera Esteve 
Published: December 2023

AbstractAlthough in theory social justice is considered as a core dimension of agroecological transitions, alternative food initiatives related to agroecology have been criticised for their exclusionary practices based on important social and economic biases. In this article, we adopt the lens of political intersectionality to study two cases of Agroecology-oriented Food Redistribution Coalitions in Spain that emerged to address the rising levels of food insecurity during the COVID-19 pandemic. We find that the coalitions represent a convergence of diverse social struggles, placing intersectionally marginalized groups at the centre of their activism. However, we also uncover that coalition members participate in different ways depending on their socioeconomic profiles, which could perpetuate inequalities in organizational practices. One major point of tension is the need to balance the goal of providing access to healthy and sustainable food with the affordability of such produce. This leads to the adoption of hybrid food networks that include conventionally produced food. We also highlight that while the predominance of women in these coalitions reflects the unequal distribution of food-related care work in society, the collectivization of such work through AFRCs practices points to a transformation of gender relations. Territorialized alliances between actors from urban and rural settings and between urban centers and peripheries are established through the coalitions. However, such networks fall short on involving large numbers of agroecology-oriented initiatives and providing direct encounters between consumers and producers. Overall, the article underscores the importance of addressing intersecting inequalities within alternative food initiatives and argues that intersectional coalitions offer an intriguing example of how to promote such understanding and pave the way towards (more) just agroecological transitions.
More than meat? Livestock farmers’ views on opportunities to produce for plant-based diets
Authors: Craft Rhiannon , Pitt Hannah 
Published: December 2023

AbstractPromoting plant-based diets as a response to climate crisis has clear implications for producers of animal derived foods, but surprisingly little research considers their perspectives on this. Our exploration focused on farming strongly associated with meat production in Wales, UK. Mindful of polarised debates around plant-based diets, we considered dietary transition as an opportunity to produce for new markets. The first aim was to identify whether transition towards plant-based diets might trigger transformation of livestock agriculture. Findings indicate a potential trigger event once livestock farmers are certain that consumer trends and climate mitigation require change. Livestock farmers who regard their meat as climate-friendly might resist transitions felt to unfairly disadvantage them. We then considered livestock farmers’ likely capacity to produce plant crops, and how this transformational capacity might be enhanced. Participants highlighted forms of financial and environmental inflexibility, plus social norms regarding “good” Welsh farmers, combining to make transformation risky. Transformational capacity might be enhanced through levering occupational and place attachments by portraying plant crops as a revival of historic practices from traditional farming landscapes. Improved linking capacity will also be beneficial, as producing for new markets requires connections to new supply chains, and learning across divisions within rural communities. We present these preliminary insights to livestock farmers’ attitudes and transformational capacity to inform future research with them to advance just agricultural transitions. Our study indicates potential to avoid confrontational discussion of dietary transition and we hope that others will pursue its focus on opportunities for farmers.
Making waves in massive star asteroseismology
Authors: Bowman Dominic M. 
Published: December 2023

AbstractMassive stars play a major role not only in stellar evolution but also galactic evolution theory. This is because of their dynamical interaction with binary companions, but also because their strong winds and explosive deaths as supernovae provide chemical, radiative and kinematic feedback to their environments. Yet this feedback strongly depends on the physics of the supernova progenitor star. It is only in recent decades that asteroseismology – the study of stellar pulsations – has developed the necessary tools to a high level of sophistication to become a prime method at the forefront of astronomical research for constraining the physical processes at work within stellar interiors. For example, precise and accurate asteroseismic constraints on interior rotation, magnetic field strength and geometry, mixing and angular momentum transport processes of massive stars are becoming increasingly available across a wide range of masses. Moreover, ongoing large-scale time-series photometric surveys with space telescopes have revealed a large diversity in the variability of massive stars, including widespread coherent pulsations across a large range in mass and age, and the discovery of ubiquitous stochastic low-frequency (SLF) variability in their light curves. In this invited review, I discuss the progress made in understanding the physical processes at work within massive star interiors thanks to modern asteroseismic techniques, and conclude with a future outlook.
Phylogenetically distant animals sleep: why do sleep researchers care?
Authors: Bechtel William 
Published: December 2023

AbstractPhilosophers examining mechanistic explanations in biology have identified heuristic strategies scientists use in discovering mechanisms. This paper examines the heuristic strategy of investigating phylogenetically distant model organisms, using research on sleep in fruit flies as an example. At the time sleep was discovered in flies in 2000 next to nothing was known about mechanisms regulating sleep in flies and what they could reveal about those in us. One relatively straightforward line of research focused on homologous genes in flies and humans, using those in flies to understand what roles their homologs played in controlling sleep in us. But other research focused on a higher level of organization—the neural networks involved in homeostatic and circadian control of sleep. This raises a puzzle—given that fly and vertebrate brains are organized very differently, how could sleep regulation in flies serve as an informative model of vertebrate sleep? I argue that the basic design of mechanisms such as those regulating sleep can be conserved even as the composition of the mechanism changes and that researchers can hope to use the designs deciphered in flies as heuristic models for understanding sleep in humans.
Effect of targeted acetylation on wood–water interactions at high moisture states
Authors: Fredriksson Maria , Digaitis Ramūnas , Engqvist Jonas , Thybring Emil E. 
Published: December 2023

AbstractAcetylation is a wood modification used to increase the durability. Although it is known that the wood moisture content is lowered, the exact mechanisms behind the increased durability are not known. However, since fungi need water in different locations for different purposes the location and state of water is most probably of importance in addition to the total moisture content. In a previous study, we used targeted acetylation to alter the wood–water interactions in different parts of the wood structure in water saturated and hygroscopic moisture states. The main range for fungal degradation is, however, between these moisture ranges. This study investigated the effect of targeted acetylation on location, state and amount of water at non-saturated, high moisture states using the pressure plate technique. Specimens were modified using acetic anhydride by two approaches: (1) uniform modification (2) interface modification acting on the cell wall-lumen interface. They were then conditioned to eight moisture states between 99.64 and 99.98% relative humidity in both absorption and desorption and the location and state of water was studied using Low Field Nuclear Magnetic Resonance, X-ray computed tomography and Differential Scanning Calorimetry. Capillary water was present at all the included moisture states for all specimen types, but the amounts of capillary water in absorption were small. Increasing degree of interface modification increased the amount of capillary water compared to untreated wood. In addition, the uniformly modified wood often had higher amounts of capillary water than the untreated wood. The amount of cell wall water was decreased by uniform modification, but slightly or not reduced by the interface modification. The combination of targeted modification and conditioning to high well-defined moisture states thus gave very different amounts of capillary water and cell wall water depending on the conditioning history (absorption or desorption) and choice of modification. This opens new possibilities for designing materials and moisture states for fungal degradation experiments of wood.
50 Years of uranium isotopic reference materials at JRC-Geel
Authors: Richter S. , Hennessy C. , Truyens J. , Jacobsson U. , Venchiarutti C. , Bujak R. , Aregbe Y. 
Published: December 2023

AbstractThe history of uranium isotopic reference materials from JRC-Geel during the last 50 years is reviewed by presenting certification methods and relevant applications. The certified isotope ratios are traceable to the SI via gravimetrical preparation, either directly through gravimetrical mixing of highly enriched materials, or indirectly using existing gravimetrically prepared reference materials for calibration of mass spectrometers used for certification measurements. Due to developments of mass spectrometers and analytical methods, certification measurements have improved regarding precision, uncertainties and accuracy. This has led to a comprehensive set of uranium isotopic reference materials available for nuclear safety, security and the scientific community.
Muscone inhibits angiotensin II–induced cardiac hypertrophy through the STAT3, MAPK and TGF-β/SMAD signaling pathways
Authors: Liu Yi-jiang , Xu Jia-jia , Yang Cui , Li Yan-lin , Chen Min-wei , Liu Shi-xiao , Zheng Xiang-hui , Luo Ping , Li Rui , Xiao Di , Shan Zhong-gui 
Published: December 2023

Abstract

Background
Muscone is a chemical monomer derived from musk. Although many studies have confirmed the cardioprotective effects of muscone, the effects of muscone on cardiac hypertrophy and its potential mechanisms are unclear.The aim of the present study was to investigate the effect of muscone on angiotensin (Ang) II-induced cardiac hypertrophy.

Methods and results
In the present study, we found for the first time that muscone exerted inhibitory effects on Ang II-induced cardiac hypertrophy and cardiac injury in mice. Cardiac function was analyzed by echocardiography measurement, and the degree of cardiac fibrosis was determined by the quantitative real-time polymerase chain reaction (qRT-PCR), Masson trichrome staining and western blot assay. Secondly, qRT-PCR experiment showed that muscone attenuated cardiac injury by reducing the secretion of pro-inflammatory cytokines and promoting the secretion of anti-inflammatory cytokines. Moreover, western blot analysis found that muscone exerted cardio-protective effects by inhibiting phosphorylation of key proteins in the STAT3, MAPK and TGF-β/SMAD pathways. In addition, CCK-8 and determination of serum biochemical indexes showed that no significant toxicity or side effects of muscone on normal cells and organs.

Conclusions
Muscone could attenuate Ang II-induced cardiac hypertrophy, in part, by inhibiting the STAT3, MAPK, and TGF-β/SMAD signaling pathways.
Differential phosphorus acquisition strategies of nine cover crop species grown in a calcareous and a decalcified chernozem
Authors: Raniro Henrique Rasera , Santner Jakob 
Published: December 2023

AbstractBackground and aimsCover cropping is a strategy to increase soil phosphorus (P) use efficiency in agroecosystems. We investigated adaptations on P acquisition strategies of nine cover crops grown in a calcareous and a non-calcareous chernozem with low available P.MethodsThrough a 108-day pot experiment using a calcareous and a decalcified chernozem, we evaluated black oat (Avena strigosaSchreb.), white lupin (Lupinus albusL.), narrow-leaf lupin (Lupinus angustifoliusL.), phacelia (Phacelia tanacetifoliaBenth.), berseem clover (Trifolium alexandrinumL.), buckwheat (Fagopyrum esculentumMoench), linseed (Linum usitatissimumL.), ramtil (Guizotia abyssinica[Lf] Cass.) and white mustard (Sinapis albaL.) for their dry biomass production, tissue P concentration and uptake, and effects on soil pH, phosphatase activity, mycorrhiza infection rate and soil P fractions.ResultsCover crops differed in several parameters between the two soils. Dry biomass varied from 3.3 (white lupin) to 41.6 g pot-1(mustard). Tissue P concentrations ranged from 0.046% (mustard) to 0.24% (clover). Species affected pH of both soils, ranging from − 0.66 to + 0.24. Acid phosphatase activity was higher in the decalcified soil, while alkaline phosphatases were higher in the calcareous soil. Root mycorrhizal infection rates ranged from 0 to > 50%. Most plants explored soil labile P exclusively, with organic P mineralization being more relevant in the calcareous soil.ConclusionWe confirm that cover crops favoured distinct strategies to access the predominant soil labile P forms in each soil. Mycorrhizal species were particularly efficient in the decalcified soil, while species with high phosphatase secretion accessed higher Po, especially in the calcareous soil.
SyDog-Video: A Synthetic Dog Video Dataset for Temporal Pose Estimation
Authors: Shooter Moira , Malleson Charles , Hilton Adrian 
Published: December 2023

AbstractWe aim to estimate the pose of dogs from videos using a temporal deep learning model as this can result in more accurate pose predictions when temporary occlusions or substantial movements occur. Generally, deep learning models require a lot of data to perform well. To our knowledge, public pose datasets containing videos of dogs are non existent. To solve this problem, and avoid manually labelling videos as it can take a lot of time, we generated a synthetic dataset containing 500 videos of dogs performing different actions using Unity3D. Diversity is achieved by randomising parameters such as lighting, backgrounds, camera parameters and the dog’s appearance and pose. We evaluate the quality of our synthetic dataset by assessing the model’s capacity to generalise to real data. Usually, networks trained on synthetic data perform poorly when evaluated on real data, this is due to the domain gap. As there was still a domain gap after improving the quality of the synthetic dataset and inserting diversity, we bridged the domain gap by applying 2 different methods: fine-tuning and using a mixed dataset to train the network. Additionally, we compare the model pre-trained on synthetic data with models pre-trained on a real-world animal pose datasets. We demonstrate that using the synthetic dataset is beneficial for training models with (small) real-world datasets. Furthermore, we show that pre-training the model with the synthetic dataset is the go to choice rather than pre-training on real-world datasets for solving the pose estimation task from videos of dogs.
The transnational prosocial activities of elite African footballers: an exploratory study of the costs and the benefits
Authors: Ejekwumadu Ikechukwu 
Published: December 2023

AbstractThis paper explored the costs and the benefits of elite African players’ prosocial activities in their home countries. Through the players’ Twitter and Instagram posts and qualitative interviews, their prosocial activities were examined with regard to the costs and benefits for their career and life courses. The findings show that African players’ transnational prosocial acts are both altruistic (placing costs) and mutualistic (generating benefits). This exploratory paper adds to the existing literature by pointing out both the material and non-material consequences of players’ transnational social responsibility activities. Further, it reveals the complex implications of these practices. For example, while participation in the national team is often viewed primarily from the perspective of positive and beneficial contributions to players’ careers, it may also pose a very significant cost to African players, as they risk jeopardising their club careers. The practical implication of this study is that football governing bodies need to do more to eliminate administrative practices that discriminate against players based on their nationality and also ensure that African players who choose to honour national team duties are protected from undue disadvantages at their clubs arising from their international duties.
Effects of spectators on the performance of a dance routine
Authors: Engler Celine , Pelzer Fabian , Kaczmarek Christian , Schaefer Sabine 
Published: December 2023

AbstractSports like dancing and gymnastics are often performed in front of an audience. It is therefore an important question whether spectators help or hinder movement execution. Previous research suggests that the influence of spectators on motor performance depends on the type of task, with condition-based tasks being facilitated, and coordination-based tasks being inhibited (for a recent review, see van Meurs, Greve, & Strauss, 2022). We tested a group of female carnival dancers (N = 15, Mage = 19; age range between 15 and 35 years) over the course of a competitive season. The same dance choreography was performed at four timepoints, each time with and without spectators. Dance performances were videotaped and afterwards rated by 7 qualified raters, who were blinded concerning the experimental condition. Raters noted an increased quality of the dance with increasing practice (linear and cubic trend). Concerning social facilitation effects, dance performance was either improved (timepoint 2) or unchanged (timepoints 1, 3, and 4) in front of the audience. Our results indicate that a complex coordination task like the carnival dance may be facilitated when being watched. Future research should address whether these findings can be replicated in other aesthetic sports (like gymnastics), whether they are influenced by gender, and how individual performances influence the group outcome.
The Role of ICP Monitoring in Minimally Invasive Surgery for the Management of Intracerebral Hemorrhage
Authors: Zhang Ge , Li Yunjie , Chen Danyang , Wu Zhuojin , Pan Chao , Zhang Ping , Zhao Xingwei , Tao Bo , Ding Han , Meng Cai , Chen Diansheng , Liu Wenjie , Tang Zhouping 
Published: December 2023

AbstractIntracerebral hemorrhage (ICH) is the second major stroke type, with high incidence, high disability rate, and high mortality. At present, there is no effective and reliable treatment for ICH. As a result, most patients have a poor prognosis. Minimally invasive surgery (MIS) is the fastest treatment method to remove hematoma, which is characterized by less trauma and easy operation. Some studies have confirmed the safety of MIS, but there are still no reports showing that it can significantly improve the functional outcome of ICH patients. Intracranial pressure (ICP) monitoring is considered to be an important part of successful treatment in traumatic brain diseases. By monitoring ICP in real time, keeping stable ICP could help patients with craniocerebral injury get a good prognosis. In the course of MIS treatment of ICH patients, keeping ICP stable may also promote patient recovery. In this review, we will take ICP monitoring as the starting point for an in-depth discussion.
Alliance for Scientific Autism Intervention: System Components and Outcome Data from High-Quality Service Delivery Organizations
Authors: Townsend Dawn Buffington , Brothers Kevin J. , MacDuff Gregory S. , Freeman Amanda , Fry Christine , Rozenblat Eric , DeFeo Donna , Budzinska Anna , Ruta-Sominka Iwona , Birkan Binyamin , Hall Laura J. , Krantz Patricia J. , McClannahan Lynn E. 
Published: December 2023

AbstractPromoting excellence in autism intervention is arguably more urgent than ever for the field of applied behavior analysis. To fulfill this objective, autism agencies must operate from validated program systems and do so with fidelity. Program components include, but are not limited to, staff training and evaluation of clinical skills, functional personnel roles designed to promote positive outcomes for those served, and professional staff-communication-skill repertoires. Data on client outcomes must be tied to implementation of core program variables; and, contingencies between the data on client outcomes and staff performance must exist. Furthermore, these contingencies must be yoked across members of the organization to ensure a sustainable and effective program model. Finally, data on consumer satisfaction must be collected and used to evaluate program components and agency practices. Members of the Alliance for Scientific Autism Intervention have implemented key program-wide systems based upon the work of McClannahan and Krantz Journal of Applied Behavior Analysis, 26, 589–596 (1993) for decades and across various agency cultures. Data collected by six independent educational agencies on client outcomes, program implementation, and consumer feedback for a 10-year time span demonstrate the sustainability of the model and support the importance of key organizational systems and the relationship between implementation of the model and high-quality outcomes for individuals with autism.