bluuebunny/crossref_metadata_2025_split huggingface dataset:
Minimally Invasive Breast Biopsy After Neoadjuvant Systemic Treatment to Identify Breast Cancer Patients with Residual Disease for Extended Neoadjuvant Treatment: A New Concept
Authors: Pfob André , Cai Lie , Schneeweiss Andreas , Rauch Geraldine , Thomas Bettina , Schaefgen Benedikt , Kuemmel Sherko , Reimer Toralf , Hahn Markus , Thill Marc , Blohmer Jens-Uwe , Hackmann John , Malter Wolfram , Bekes Inga , Friedrichs Kay , Wojcinski Sebastian , Joos Sylvie , Paepke Stefan , Degenhardt Tom , Rom Joachim , Rody Achim , van Mackelenbergh Marion , Banys-Paluchowski Maggie , Große Regina , Reinisch Mattea , Karsten Maria Margarete , Sidey-Gibbons Chris , Wallwiener Markus , Golatta Michael , Heil Joerg 
Published: November 2023

Abstract
Background
Breast cancer patients with residual disease after neoadjuvant systemic treatment (NAST) have a worse prognosis compared with those achieving a pathologic complete response (pCR). Earlier identification of these patients might allow timely, extended neoadjuvant treatment strategies. We explored the feasibility of a vacuum-assisted biopsy (VAB) after NAST to identify patients with residual disease (ypT+ or ypN+) prior to surgery.

Methods
We used data from a multicenter trial, collected at 21 study sites (NCT02948764). The trial included women with cT1-3, cN0/+ breast cancer undergoing routine post-neoadjuvant imaging (ultrasound, MRI, mammography) and VAB prior to surgery. We compared the findings of VAB and routine imaging with the histopathologic evaluation of the surgical specimen.

Results
Of 398 patients, 34 patients with missing ypN status and 127 patients with luminal tumors were excluded. Among the remaining 237 patients, tumor cells in the VAB indicated a surgical non-pCR in all patients (73/73, positive predictive value [PPV] 100%), whereas PPV of routine imaging after NAST was 56.0% (75/134). Sensitivity of the VAB was 72.3% (73/101), and 74.3% for sensitivity of imaging (75/101).

Conclusion
Residual cancer found in a VAB specimen after NAST always corresponds to non-pCR. Residual cancer assumed on routine imaging after NAST corresponds to actual residual cancer in about half of patients. Response assessment by VAB is not safe for the exclusion of residual cancer. Response assessment by biopsies after NAST may allow studying the new concept of extended neoadjuvant treatment for patients with residual disease in future trials.
Radial peripapillary capillary density as a predictive factor for glaucoma in eyes with ocular hypertension. An observational, comparative, single-centred study
Authors: Kollia Elpida , Christou Evita-Evangelia , Patsea Eleni , Papadonta Styliani Alexia , Papaconstantinou Dimitris 
Published: November 2023

Background: Ocular hypertension (OH) is a condition characterized by elevated intraocular pressure (IOP) exceeding the normal range, without any evident damage to the optic nerve or visual field defects characteristic of glaucoma. It constitutes a significant precursor to the development of glaucoma, a leading cause of irreversible vision loss worldwide. Emerging evidence has shown that microcirculation alterations in eyes with OH could serve as predicting factors to identify eyes at high risk for progression to glaucoma. In view of the above, the purpose of our study is to investigate microcirculation alterations of the radial peripapillary capillary plexus using optical coherence tomography angiography (OCT-A) in patients with ocular hypertension (OH). Methods: A total of 192 eyes were included in this observational, comparative, single-centre study and were divided in two groups: OH eyes and healthy controls. OCT-A was performed to analyze microcirculation characteristics at the peripapillary area. Radial peripapillary capillary density was measured at the total area of the optic disc and at each separate region (superior, inferior, inside). The parameters of age, medical treatment for ocular hypertension, sex and retinal fiber layer thickness were evaluated. Results: Total radial peripapillary capillary density was significantly lower in patients with OH than in healthy controls Concerning the microcirculation characteristics at each separate region of the peripapillary area, the results were as follows: inferior radial peripapillary capillary density was significantly decreased in individuals with OH than in controls, while measurements in the superior peripapillary area and internal optic disc were similar in both groups. Conclusions: Our study indicates decreased radial peripapillary capillary density in eyes with OH. Microcirculation alterations in the inferior peripapillary area could potentially comprise biomarkers for OH progression to glaucoma.
A protocol to study the impact of implementation of National Accreditation Board for Hospitals & Healthcare Providers (NABH) standards among health care workers in a tertiary care hospital in India
Authors: Kanyal Deepika , Ghewade Babaji 
Published: November 2023

Background: The healthcare system is now transforming widely with new technology including the introduction of a variety of medical gadgets, clinical trials, telemedicine, health insurance, health tourism, and outsourcing programs. Recent research focused on the quality of healthcare has proved useful for evaluating satisfaction and improvement of services in an organization. The World Medical Assembly asserts that in order to enhance patient outcomes on an individual level and community health, healthcare providers and organizations have an ethical and professional commitment to continuously improve the quality of services and patient safety. The National Accreditation Board for Hospitals & Healthcare Providers - Quality Council of India - (NABH) formed a constituent board to design and oversee an accreditation scheme for healthcare institutions to ensure the quality of care. Healthcare accreditation organizations and certification programs have progressed international efforts to raise the standard of healthcare since the 1970s. The accreditation process, which is carried out by qualified external peer reviewers, allows a healthcare organization to be officially recognized for achieving performance standards. The objectives of this protocol are to understand the perception and impact of healthcare workers towards implementation of NABH standards and to study the impact of pre and post assessment of NABH with the help of 10 important key performance indicators in hospitals. Methods: A descriptive cross-sectional design will be adopted in the study. It includes collection of data from the medical record department records for pre-assessment and direct questionnaire to the participants for post-assessment of NABH standards. The pre-assessment data of quality indicators will be collected from the previous records of NABH files from the quality assurance department. Expected result: The expected result of the study will identify the different impacts of implementation of NABH standards after pre and post assessment in an organization.
Organized Crime and Firms: Evidence from Antimafia Enforcement Actions
Authors: Slutzky Pablo , Zeume Stefan 
Published: November 2023

We exploit staggered municipality-level antimafia enforcement actions in Italy over the 1995–2015 period to study how the presence of organized crime affects firms. Following enforcement actions, we find increases in competition (i) among firms and (ii) for public procurement contracts. Firms that do not exit after a weakening of organized crime shrink in size, more so when operating in the nontradable sector. Our findings are consistent with organized crime acting as a barrier to entry and affecting local economic activity. This paper was accepted by David Sraer, finance. Supplemental Material: Data and the online appendix are available at https://doi.org/10.1287/mnsc.2021.00859 .
Highly efficient nonlinear vortex beam generation by using a compact nonlinear fork grating
Authors: Yang Yangfeifei , Li Hao , Liu Haigang , Chen Xianfeng 
Published: November 2023

Vortex beams with an orbital angular momentum (OAM) are extremely important in optical trapping, optical micromachining, high-capacity optical communications, and quantum optics. Nonlinear generation of such a vortex beam enables vortex beams to be obtained at new wavelengths, which opens up new possibilities for all-optical switching and manipulation of vortex beams. However, previous nonlinear vortex beam generation suffers from either low efficiency or low-level integration. Here, we use the technique of ultraviolet photolithography-assisted inductively coupled plasma (ICP) etching to realize a compact nonlinear fork grating for high-efficiency nonlinear vortex beam generation. In our experiment, the depth of such a compact nonlinear fork-grating structure can be precisely controlled by etching time. The vortex beams with a topological charge of
l
= ±1,  ± 2,  ± 3 can be generated in the far field, and the normalized nonlinear conversion efficiency of such nonlinear vortex beam is 189% W−1cm−2. Our method not only provides an efficient and compact method for nonlinear vortex beam manipulation but also suits for timesaving and large-area nonlinear functional device fabrication.
Real-time, chirped-pulse heterodyne detection at room temperature with 100 GHz 3-dB-bandwidth mid-infrared quantum-well photodetectors
Authors: Lin Quyang , Hakl Michael , Lepillet Sylvie , Li Hua , Lampin Jean-François , Peytavit Emilien , Barbieri Stefano 
Published: November 2023

Thanks to intrinsically short electronic relaxation on the ps time scale, III-V semiconductor unipolar devices are ideal candidates for ultrahigh-speed operation at mid-infrared frequencies. In this work, antenna-coupled, GaAs-based multi-quantum-well photodetectors operating in the 10–11 µm range are demonstrated, with a responsivity of 0.3 A/W and a 3-dB-cutoff bandwidth of 100 GHz at room temperature. The frequency response is measured up to 220 GHz: beyond 100 GHz we find a roll-off dominated by the 2.5-ps-long recombination time of the photo-excited electrons. The potential of the detectors is illustrated by setting up an experiment where the time dependent emission frequency of a quantum cascade laser operated in pulsed mode is measured electronically and in real time, over a frequency range >60GHz. By exploiting broadband electronics, and thanks to its high signal-to-noise ratio, this technique allows the acquisition, in a single-shot, of frequency-calibrated, mid-infrared molecular spectra spanning up to 100 GHz and beyond, which is particularly attractive for fast, active remote sensing applications in fields such as environmental or combustion monitoring.
Referenzarchitektur Cybersicherheit im Föderalsystem Deutschlands
Authors: Rehbohm Thomas , Sandkuhl Kurt 
Published: November 2023

ZusammenfassungCybersicherheitsarchitekturen sind im Föderalsystem Deutschlands elementarer Bestandteil der digitalen Daseinsvorsorge für Gesellschaft, Wirtschaft und Verwaltung. In Deutschland stehen neben dem Bund alle Länder vor vergleichbaren Herausforderungen, die Akteure ihrer Region dergestalt in eine Architektur einzubinden, dass eine gegenüber Cybersicherheitsbedrohungen resiliente IKT-Infrastruktur entsteht. Sofern die Länder eine harmonisierte Architektur implementiert haben, kann die Gesamtarchitektur im Binnenverhältnis der Länder in kooperativer und komplementärer Zusammenarbeit mit dem Bund und für Europa aufwachsen. Das Ziel der hier vorgestellten Forschungsarbeit ist es, die Verzahnung der systemrelevanten Akteure der regionalen und föderalen Cybersicherheit zu unterstützen und zu vereinfachen. Konkret werden dazu sowohl die inter-organisationalen Prozesse und davon betroffenen Rollen und Organisationseinheiten bei Land, Kommune und Unternehmen der Privatwirtschaft als auch gemeinsam nutzbare Komponenten einer Cybersicherheitsorganisation betrachtet und in Form einer Unternehmensarchitektur dokumentiert, die zu einer Referenzarchitektur weiterentwickelt werden soll. Die Modellierung der Referenzarchitektur in der Modellierungssprache ArchiMate wird in Auszügen vorgestellt.
Development of youth tennis players: A study based on the ranking history of top ATP/WTA players worldwide and China
Authors: Chen Hui , Li Caifeng , Meng Xianlu , Chmura Paweł , Wei Xiaobin 
Published: November 2023

Background
The top 100 ATP/WTA ranking points are a crucial indicator of entry into the high-level world of tennis players, and the number of players from a nation in this ranking reflects the overall level of their tennis. However, the growth time series characteristics of elite tennis athletes are unclear.

Objective
This study aims to examine the historical career ranking changes of elite players and provide valuable insights for aspiring young players looking to achieve success in the sport. At the same time, it is of great significance for the efficient and sustainable cultivation of Chinese tennis players.

Methods
Data on the rankings of 202 players were analyzed, Spearman and Pearson correlations were employed to investigate the association between ranking and time-use patterns. The variance test was utilized to compare disparities in time characteristics of the ranking, with a statistical significance level of p<0.05.

Results
There was a significant correlation between the time of entering the professional tournament ranking system and the ranking, top 100 time, top 100 age, and age of starting tennis. Top 50 ATP players are earlier than those ranked 51–100. There was a significant difference between the age of starting tennis and the time to top 10 among the ATP and WTA players. Chinese female players showed no significant differences compared to their global Top 10 counterparts in terms of time-to-success characteristics.

Conclusion
The elite tennis players who achieve success typically start playing and competing in the sport at a young age, with professional competition often commencing around 18 years of age. Notably, these players frequently attain high rankings before reaching the age of 20. Furthermore, top 10 ATP male players tend to start tennis at an earlier age and require a shorter time to achieve a top 10 ranking compared with WTA female players.
Medical Admission Prediction Score (MAPS); a simple tool to predict medical admissions in the emergency department
Authors: Zahid Muhammad , Khan Adeel Ahmad , Ata Fateen , Yousaf Zohaib , Naushad Vamanjore Aboobacker , Purayil Nishan K. , Chandra Prem , Singh Rajvir , Kartha Anand Bhaskaran , Elzouki Abdelnaser Y. Awad , Al Mohanadi Dabia Hamad S. H. , Al-Mohammed Ahmed Ali A. A. 
Published: November 2023

Introduction
Overcrowding in the emergency departments (ED) is linked to adverse clinical outcomes, a negative impact on patient safety, patient satisfaction, and physician efficiency. We aimed to design a medical admission prediction scoring system based on readily available clinical data during ED presentation.

Methods
In this retrospective cross-sectional study, data on ED presentations and medical admissions were extracted from the Emergency and Internal Medicine departments of a tertiary care facility in Qatar. Primary outcome was medical admission.

Results
Of 320299 ED presentations, 218772 were males (68.3%). A total of 11847 (3.7%) medical admissions occurred. Most patients were Asians (53.7%), followed by Arabs (38.7%). Patients who got admitted were older than those who did not (p <0.001). Admitted patients were predominantly males (56.8%), had a higher number of comorbid conditions and a higher frequency of recent discharge (within the last 30 days) (p <0.001). Age > 60 years, female gender, discharge within the last 30 days, and worse vital signs at presentations were independently associated with higher odds of admission (p<0.001). These factors generated the scoring system with a cut-off of >17, area under the curve (AUC) 0.831 (95% CI 0.827–0.836), and a predictive accuracy of 83.3% (95% CI 83.2–83.4). The model had a sensitivity of 69.1% (95% CI 68.2–69.9), specificity was 83.9% (95% CI 83.7–84.0), positive predictive value (PPV) 14.2% (95% CI 13.8–14.4), negative predictive value (NPV) 98.6% (95% CI 98.5–98.7) and positive likelihood ratio (LR+) 4.28% (95% CI 4.27–4.28).

Conclusion
Medical admission prediction scoring system can be reliably applied to the regional population to predict medical admissions and may have better generalizability to other parts of the world owing to the diverse patient population in Qatar.
Evaluating the impact of sling provision and training upon maternal mental health, wellbeing and parenting: A randomised feasibility trial
Authors: Wigglesworth Helen , Huddy Vyv , Knowles Rosie , Millings Abigail 
Published: November 2023

Background
Close body contact interventions such as Kangaroo Mother Care have been shown to improve maternal mental health following birth. Infant carriers (‘slings’) facilitate hands-free close body contact. No studies have specifically examined whether sling use improves maternal mental health. A full-scale efficacy study is needed to examine whether sling use is beneficial to maternal mental health. The current study is a feasibility study designed to gather information to support the design of a future RCT, such as acceptability and study parameters, including recruitment rates, consent rate and attrition.

Method
Mothers of infants aged 0–6 weeks were randomised to one of two conditions: intervention (n = 35) vs. waitlist control (n = 32). Intervention participants received sling training, support, and free sling hire for 12 weeks. Participants completed self-report measures of mood, wellbeing and parenting at baseline (Time 1), and 6- (Time 2) and 12- (Time 3) weeks post-baseline.

Results
Eligibility and consent rates met feasibility objectives, though there were some difficulties with retention of participants in the study. Preliminary effectiveness analyses showed a non-significant improvement with a small effect size in postnatal depression from T1 to T3, and a significant improvement with a medium effect size in maternal self-efficacy from T1 to T3. Qualitative feedback indicated acceptability of the intervention and study participation. Intervention participants attributed greater autonomy, bonding with their baby, and parental self-confidence, to the intervention.

Conclusions
These findings indicate a randomised study of the impact of a sling and related support intervention upon maternal mental health is feasible. These findings should be interpreted within the context of sampling bias (due to the use of volunteer sampling methods), an absence of feedback from those who discontinued participation in the study, and the study not being adequately powered.

Trial registration
Registration number ISRCTN88575352.
Prevalence and incidence of sexually transmitted infections among South African women initiating injectable and long-acting contraceptives
Authors: Harryparsad Rushil , Meyer Bahiah , Taku Ongeziwe , Serrano Myrna , Chen Pai Lien , Gao Xiaoming , Williamson Anna-Lise , Mehou-Loko Celia , d’Hellencourt Florence Lefebvre , Smit Jennifer , Strauss Jerome , Nanda Kavita , Ahmed Khatija , Beksinska Mags , Buck Gregory , Morrison Charles , Deese Jennifer , Masson Lindi 
Published: November 2023

Background
South Africa is among the countries with the highest prevalence of sexually transmitted infections (STIs), including Chlamydia trachomatis (CT) and Neisseria gonorrhoeae (NG). In 2017, there were an estimated 6 million new CT, 4.5 million NG and 71 000 Treponema pallidum infections among South African men and women of reproductive age.

Methods
We evaluated STI prevalence and incidence and associated risk factors in 162 women aged 18–33 years old, residing in eThekwini and Tshwane, South Africa who were part of the Evidence for Contraceptive Options and HIV Outcomes (ECHO) trial. Women were randomised to use depot medroxyprogesterone acetate (n = 53), copper intrauterine device (n = 51), or levonorgestrel (n = 58) implant. Lateral vaginal wall swab samples were collected prior to contraceptive initiation and at months one and three following contraceptive initiation for STI testing.

Results
There were no significant differences in STI incidence and prevalence across contraceptive groups. At baseline, 40% had active STIs (CT, NG, Trichomonas vaginalis (TV), Mycoplasma genitalium (MG) or herpes simplex virus-2 shedding across all age groups– 18–21 years (46%), 22–25 years (42%) and 26–33 years (29%). The incidence of STIs during follow-up was exceptionally high (107.9/100 women-years [wy]), with younger women (18–21 years) more likely to acquire CT (75.9/100 wy) compared to 26–33 year olds (17.4/100 wy; p = 0.049). TV incidence was higher in the 26–33 year old group (82.7/100 wy) compared to the 18–21 year olds (8.4/100 wy; p = 0.01).

Conclusions
Although the study participants received extensive counselling on the importance of condom use, this study highlights the high prevalence and incidence of STIs in South African women, especially amongst young women, emphasising the need for better STI screening and management strategies.
Pharmacoepidemiological analysis of type 1 diabetes mellitus insulin therapy (According to the Moscow segment of the State Register of Diabetes Mellitus)
Authors: Antsiferov M. B. , Kantemirova M. A. , Demidov N. A. , Kalashnikova M. F. 
Published: November 2023

BACKGROUND: When developing programs for state reimbursement of the cost of medical services and medicines, when providing assistance to patients suffering from type 1 diabetes mellitus (DM1), data based on the results of pharmacoepide-miological studies (FEI) conducted in real clinical practice of treating patients are needed. The obtained results of the analysis of drug consumption allow us to study the most commonly used insulin therapy regimens and their compliance with modern clinical recommendations. Calculations of the weighted average cost of conducting hypoglycemic therapy in DM1 can be used for further pharmacoeconomical calculations, including analysis of the medical and social cost of the disease.AIM: To conduct a pharmacoepidemiological analysis of the consumption of insulin preparations according to the ATX /DDD methodology, to study the modes of insulin administration and the ratio of the weighted average cost of insulin therapy components per 1 patient with DM1 per year in the outpatient practice of treatment with the introduction of insulin in the mode of multiple injections of insulin (MII) and during continuous subcutaneous insulin infusion (CSII).MATERIALS AND METHODS: A retrospective continuous cohort analytical pharmacoepidemiological study was conducted on the basis of the SRDM database (status as of 01/01/2020), in which 17,617 patients with T1DM aged 18 years and older were registered at the time of the study.RESULTS: 90% of patients received analogues of human insulin in the MII mode using syringe pens, 8.6% used the CSII mode. In 34.5% of patients with DM1 HbA1c was <7%, the proportion of patients with HbA1c >8% was 28%. The average cost of insulin therapy per 1 person per year was 54,977 rubles. The cost of basal insulin treatment per 1 patient per year was approximately 1.5 times higher than the cost of bolus insulin during insulin therapy in the MII mode (33,960 rubles and 21,017 rubles, respectively). The weighted average cost of insulin per 1 patient per year for CSII was 31,822 rubles.CONCLUSION: The majority of patients with DM1 in the study cohort received analogues of human insulin in the basic bolus mode of MII using syringe pens, which corresponds to existing clinical recommendations. The proportion of patients achieving the goals of glycemic control is comparable to the data obtained on the basis of registers of diabetic patients in other economically developed countries