bluuebunny/crossref_metadata_2025_split huggingface dataset:
Toddler dietary patterns from the INSIGHT randomized clinical trial comparing responsive parenting versus control: A latent class analysis
Authors: Hernandez Erika , Hohman Emily E. , Ferrante Mackenzie J. , Anzman‐Frasca Stephanie , Paul Ian M. , Savage Jennifer S. 
Published: October 2023

AbstractObjectiveThe aim of this study was to examine the effect of a responsive parenting (RP) intervention on toddler diet and explore associations with mothers' infant feeding practices and child weight status.MethodsINSIGHT tested an RP intervention designed for the prevention of obesity against a safety control among primiparous mothers and their infants. Mothers reported on feeding practices, as well as toddler diet with a Food Frequency Questionnaire (n = 229). Trained research staff obtained child anthropometrics at age 2 years.ResultsLatent class analysis identified three dietary patterns: high fruits and vegetables (HFV, 31%); meat, potatoes, and added sugars (MPAS, 24%); and high juice, low fruits and vegetables (JLFV, 45%). Toddler dietary pattern was not related to study group (RP, control) or child weight status at age 2 years. Mothers who reported more structure‐based feeding had toddlers that were more likely to have the healthier, HFV dietary pattern than MPAS and JLFV. Findings for control‐based feeding practices were mixed; maternal restriction was associated with the HFV dietary pattern, whereas the use of food as a reward was associated with MPAS and JLFV.ConclusionsMothers' structure‐based feeding practices in infancy, as well as some control‐based feeding practices, were associated with later healthier toddler dietary patterns.
Busulfan and subsequent malignancy: An evidence‐based risk assessment
Authors: Long‐Boyle Janel R. , Kohn Donald B. , Shah Ami J. , Spencer Sueli Marques , Sevilla Julian , Booth Claire , López Lorenzo José Luis , Nicoletti Eileen , Shah Arpita , Reatz Meredith , Matos Joana , Schwartz Jonathan D. 
Published: October 2023

AbstractBackgroundThe incidence of secondary malignancies associated with busulfan exposure is considered low, but has been poorly characterized. Because this alkylating agent is increasingly utilized as conditioning prior to gene therapy in nonmalignant hematologic and related disorders, more precise characterization of busulfan's potential contribution to subsequent malignant risk is warranted.ProcedureWe conducted a literature‐based assessment of busulfan and subsequent late effects, with emphasis on secondary malignancies, identifying publications via PubMed searches, and selecting those reporting at least 3 years of follow‐up.ResultsWe identified eight pediatric and 13 adult publications describing long‐term follow‐up in 570 pediatric and 2076 adult hematopoietic cell transplant (HCT) recipients. Secondary malignancies were reported in 0.5% of pediatric HCT recipients, with no cases of myelodysplastic syndrome (MDS) or acute myelocytic leukemia (AML). Fatal secondary malignancies were reported in 0.8% of 1887 evaluable adult HCT recipients, and an overall incidence of secondary malignancies of 4.8% was reported in a subset of 389 evaluable adult patients. We also reviewed long‐term results from eight publications evaluating lentiviral‐ and human promotor‐based HSC‐targeted gene therapy in 215 patients with nonmalignant conditions, in which busulfan/treosulfan monotherapy or busulfan/fludarabine was the only conditioning. Two malignancies were reported in patients with sickle cell disease (SCD), one of which was potentially busulfan‐related. No additional malignancies were reported in 173 patients with follow‐up of 5–12 years.ConclusionThe incidence of busulfan‐related secondary malignancies is low, and likely to be substantially less than 1% in pediatric transplant recipients, especially those receiving busulfan monotherapy for nonmalignant conditions other than SCD.
Role of the inter‐ply microstructure in the consolidation quality of high‐performance thermoplastic composites
Authors: Arquier R. , Sabatier H. , Iliopoulos I. , Régnier G. , Miquelard‐Garnier G. 
Published: October 2023

AbstractConsolidation of Carbon Fiber (CF)/high‐performance thermoplastic composites is much less understood than the one of their thermoset counterparts. It is usually assumed that the consolidation quality is directly linked to the removal of voids within the sample during consolidation, leading to mechanical properties suitable for aerospace applications. A systematic study of the temporal evolution of CF/polyetherketoneketone (PEKK) samples' microstructure consolidated under low pressure in a rheometer is related to the increase in inter‐laminar shear strength. The results show that despite similar void contents well‐below 1 vol%, samples can present significant differences in ILSS values, from 80 to 95 MPa for cross‐ply samples, and from 98 to 112 MPa for unidirectional (UD) ones. A microstructural analysis shows that, for these materials, consolidation quality is rather related to a reorganization of the inter‐ply, a resin‐rich (~70 vol%) region of typical thickness 10 μm which is slowly repopulated in fibers during consolidation.Highlights
Microstructure of CF/PEKK composites is characterized over consolidation time
Contrary to thermosets void content cannot be used to predict mechanical properties
ILSS increase over consolidation time is related to inter‐ply reorganization
Inter‐ply microstructure and ILSS have a direct correlation
The repopulation in fibers of the resin‐rich inter‐ply is a slow process
Effect of early postoperative enteral nutrition on the short‐term prognosis in neonatal gastric perforation
Authors: Zhu Ting , Liu Yu , Wei Huan , Tang Shuo , Li Xiaowen , Cui Mengying , Shi Yuan , Wang Zheng‐Li 
Published: October 2023

AbstractThe aim of this retrospective study was to investigate the impact of early postoperative enteral nutrition on the short‐term prognosis of neonatal gastric perforation. The 63 neonates were divided into two groups based on enteral nutrition timing: the early enteral nutrition (EEN) group (≤15 days) and the late enteral nutrition (LEN) group (>15 days). The EEN group was additionally matched with the LEN1 group based on closely aligned gestational age (difference ≤6 days), birth weight (difference <250 g), and age of onset (<1 day). Data from the EEN, LEN, and LEN1 groups were compared and analyzed. No significant differences were observed among the groups in baseline characteristics such as gestational age, birth weight, age at hospital admission, cesarean section rate, and so on (p > 0.05). Furthermore, preoperative comorbidities, clinical symptoms, and examination results were not significantly different between the three groups (p > 0.05). However, the time required to achieve total enteral nutrition, the length of hospital stay, and fistula retention time were significantly less in the EEN group compared to the LEN groups (p < 0.05). The EEN group also exhibited a shorter gastrointestinal decompression time than the LEN1 group, but other major postoperative outcome measures were not significantly different. In conclusion, our study suggests that early postoperative enteral nutrition (≤15 days) could reduce the time to total enteral nutrition, length of hospital stay, and fistula retention time, without increasing adverse prognosis rates.
Cluster Gauss‐Newton method for a quick approximation of profile likelihood: With application to physiologically‐based pharmacokinetic models
Authors: Aoki Yasunori , Sugiyama Yuichi 
Published: October 2023

AbstractPhysiologically‐based pharmacokinetic (PBPK) models can be challenging to work with because they can have too many parameters to identify from observable data. The profile likelihood method can help solve this issue by determining parameter identifiability and confidence intervals, but it involves repetitive parameter optimizations that can be time‐consuming. The Cluster Gauss‐Newton method (CGNM) is a parameter estimation method that efficiently searches through a wide range of parameter space. In this study, we propose a method that approximates the profile likelihood by reusing intermediate computation results from CGNM, allowing us to obtain the upper bounds of the profile likelihood without conducting additional model evaluation. This method allows us to quickly draw approximate profile likelihoods for all unknown parameters. Additionally, the same approach can be used to draw two‐dimensional profile likelihoods for all parameter combinations within seconds. We demonstrate the effectiveness of this method on three PBPK models.
The Raman spectrum and the molecular structure of phosphorus trioxydisulphide P4O6S4
Authors: Gerding H. , van Brederode H. 
Published: October 2023

AbstractThe preparation and purification in a vacuum of phosphorus trioxydisulphide is described. The Raman spectrum of the molten substance in an evacuated tube at 130° was determined, and polarization measurements were effected for the Raman lines also. At 130° ‐ accelerated by the light ‐ a separating out of solid particles is observed. It is pointed out that polymerization into linear and chain branched polymers takes place, a supposition that is also confirmed by other still unpublished results.The Raman spectrum of the liquid contains a number of lines which are practically completely polarized, which proves that in the liquid scattering particles of cubical symmetry are present, in all probability molecules of P4O6S4. The number of strongly polarized Raman lines is definitely too high for each cubical compound. An explanation of this fact may be given by keeping in mind that polymerization as well as depolymerization phenomena take place in the liquid, so that cubic molecules of P4O6S4 with oxygen and sulphur interchanged and different kinds of linear polymers etc. may occur. The appearance in the Raman spectrum of a strongly polarized Raman line with Δ 1396 cm−1, proves the presence in the liquid of scattering single molecules of composition P4O6S4 with an oxygen atom attached by a double bond to an atom of phosphorus.The Raman spectrum of the solid shows a general agreement with that of the liquid (with the weakest lines of the latter spectrum being absent in that of the solid), proving that solid P4O6S4 for the greater part consists of normal molecules of P4O6S4.
Benzylidine‐N‐phenylhydrazine‐1‐carboxamide Derivatives as Tyrosinase Inhibitors: Design, Preparation, Molecular Docking, and Biological Activity
Authors: Hamedifar Halleh , Karimian Somaye , Kabiri Maryam , Bagheri Azam , Zarei Mina , Moazzam Ali , Mahdavi Mohammad , Sepehri Nima , Khoshneviszadeh Mehdi 
Published: October 2023

AbstractTen novel benzylidine‐N‐phenylhydrazine‐1‐carboxamide derivatives (7 a–7 j) were synthesized in three steps and evaluated for their tyrosinase inhibitory and antioxidant activities. The spectrophotometric method with L–DOPA as a substrate was used to determine tyrosinase inhibitory activities, and a DPPH assay was used to evaluate antioxidant properties. Among the synthesized compounds, compound 7 c with an ethyl substitution on the C2‐N‐phenylacetamide ring showed the highest tyrosinase‐inhibition activity (IC50=4.36±1.58 μM), which was comparable with that of standard kojic acid (IC50=16.34±1.93 μM). Compounds (7 d) and (7 e) showed potent antioxidant activities (EC50=52.11±4.18 and 92.47±3.32 μM, respectively), which were comparable to those of quercetin. The study of the interactions and binding modes of the tested compounds was accomplished with molecular docking. Docking results corroborated that the active inhibitors were well placed in the mushroom tyrosinase enzyme‘s active site.
Efficient Four‐Component Synthesis of 1,2,4‐Triazolo[1,5‐a]pyrimidines and Their In Vitro Antiproliferative Studies
Authors: Venkatesham Papisetti , Kalonia Mansi , Sangolkar Akanksha Ashok , Mudiraj Anwita , Babu Phanithi Prakash , Vedula Rajeswar Rao 
Published: October 2023

AbstractTriazolopyrimidines are emerging as potential anticancer agents. Herein, we report a novel one‐pot four component synthesis of 2‐((2‐oxo‐2‐phenylethyl/benzyl)thio)‐10‐phenyl‐4,10‐dihydro‐9H‐indeno[1,2‐d][1,2,4]‐Triazolo[1,5‐a]pyrimidin‐9‐ones by the reaction of 1,3‐indanedione, aromatic aldehyde, 5‐amino‐4H‐1,2,4‐Triazol‐3‐thiol and phenacyl bromide in acetic acid with piperidine as catalyst at 90 °C for 13 hours. All the final compounds were identified on the basis of their FT‐IR, 1H NMR, 13C NMR and HRMS. The synthesized compounds were evaluated for their cell growth inhibition potential using MTT and wound healing assay, 13 compounds induced concentration dependent inhibition with IC50 below 10 μM against breast cancer cell lines (MCF‐7). Further, the molecular docking simulation were carried out for all the derivatives, amongst these thio phenacyl, 2,4‐dichlorophenyl 9H‐indeno [1,2,4]‐Triazolo[1,5‐a]pyrimidin‐9‐one (5 g) shows good binding interaction with amino acid residues. This is further confirmed by wound healing assay which shows that 5 g inhibits cell migration at increasing concentrations.
Developing a prognostic model for stress reduction in patients with prolonged work‐related stress
Authors: Jensen Johan Høy , Rugulies Reiner , Flachs Esben Meulengracht , Petersen Kajsa Ugelvig , Ross Lone , Eller Nanna Hurwitz , Khoury Bassam 
Published: October 2023

AbstractMindfulness‐based stress reduction (MBSR) is a 9‐session group‐treatment programme for managing stress. Research suggests variability in the outcomes of MBSR among participants. This prognostic (not causal) study develops a multivariable model that may support clinicians in forecasting expected MBSR outcomes. We used data of 763 patients collected from MBSR programs conducted between October 2015 and March 2022. Candidate prognostic factors at baseline included psychosocial work environment, sociodemographic, and clinical information. Multiple imputation was used to handle missing data (imputations = 200). Important prognostic factors were backward selected in ≥5% of the imputed datasets. The final prediction model including the selected prognostic factors was evaluated using linear regression with a four‐fold internal cross‐validation procedure. Reductions in perceived stress from baseline to end of the MBSR programme were predicted by a lower General Severity Index (β = 2.00, p < 0.01), higher baseline levels of stress (β = −0.88, p < 0.01), and somewhat by having managerial responsibility in the latest job (vs. no; β = −2.53, p = 0.07). The remaining prognostic factors were weaker predictors, for example, gender and income. Internal validity of the final model was indicated by consistent results from four randomly folded subsamples. This study developed a prognostic model predicting changes in stress levels in relation to the MBSR programme. A reduction in stress level was particularly predicted by milder psychological symptoms and higher baseline levels of perceived stress. These predictions cannot be taken as evidence of causal associations. Forecasting of the illness course should be cautiously practiced using clinical judgement regarding individual patients.
Water quality monitoring and assessment in coastal lagoons: Developing a protocol using a case study in Sainthamaruthu lagoon, Sri Lanka
Authors: Begum Sulaima Lebbe Rasmiya , Weragoda Sujithra Kaushaliya , Mowjood Mohamed Ismail Mohammed 
Published: October 2023

AbstractSustainable water resources management requires monitoring and assessment of water quality in addition to quantity. Coastal lagoons play a critical role for the people and the ecosystem at large. Water quality monitoring and assessment for lagoons in Sri Lanka is important considering its services to the country. However, due to a lack of resources, most of the lagoons are not monitored and reported properly for further action. This study aims to develop a protocol in terms of monitoring sites, parameters, and frequency for water quality monitoring using a case study in a coastal lagoon, in Sainthamaruthu, Sri Lanka. The physicochemical parameters were measured weekly at eighteen monitoring sites for 4 months during the dry season from June to September 2022. Cluster analysis (CA) along with Inverse Distance Weighted (IDW) interpolation technique revealed that a minimum of three sites out of 18 are sufficient for monitoring water quality in the lagoon. In light of Principal Component Analysis (PCA) and Discriminant Analysis (DA), it was decided to retain temperature, pH, turbidity, Total Dissolved solids (TDS), Electrical Conductivity (EC), and Dissolved Oxygen (DO) in monitoring programs, since they cumulatively account for 79% of the variation in water quality in the lagoon spatially and temporally. Monitoring turbidity, TDS, and EC at weekly interval, while monitoring temperature, pH, and DO at biweekly or monthly is recommended. A further indication of the lagoon's water quality is that the mean values for turbidity (27 NTU), EC (754 μS/cm), and DO (4.6 ppm) higher than ambient standards, while TDS (344 ppm) and pH (6.98) are within. Therefore, we conclude that the lagoon requires remediation measures to be suitable for environmental purposes during dry periods.
Multi‐attribute decision‐making: Use of scoring methods to choose the best form of dietary fat supplement in pregnant Saanen goats
Authors: Javaheri Barfourooshi Hoda , Sadeghipanah Hassan , Asadzadeh Nader , Hosseini Seyed Abdullah , Alizadeh‐Ghamsari Amir Hossein 
Published: October 2023

AbstractBackgroundNutritional manipulation with functional nutrients like polyunsaturated fatty acids can boost milk production efficiency in dairy farming. It is important to consider the animal's physiological periods, especially the second half of the first pregnancy for mammary gland development.ObjectivesBy considering multiple factors and comparing them, multi‐attribute decision‐making (MADM) can be utilized to conduct further assessments and select the best diet for the animals.MethodsForty primiparous Saanen does, from the last 2 months of pregnancy up to 4 months of lactation, have been assigned to four iso‐energetic and iso‐nitrogenous diets. Four dietary groups included: no external sources of fat (negative control, CT), saturated palm oil (positive control), roasted soybeans (omega‐6, SB) and extruded flaxseed (omega‐3, FS). Twenty‐two performance criteria such as feed intake, milk yield and composition, body weight, blood metabolites and hormones, the milk fatty acid profile, as well as morphological and histological measurements of the mammary gland, in the form of least‐square means, were considered.ResultsA decision‐making tool was used to select the best form of fat supplements in late pregnancy and early lactation diets, to improve lactation performance in Saanen goats. For this purpose, a MADM method was applied to determine the order of preference similarity to the ideal solution. According to the score of this method, the FS group had the highest coefficients (0.689), and the CT group had the lowest coefficients (0.281).ConclusionsIncorporating flaxseed into the diets of Saanen goats during late pregnancy and early lactation is a valuable strategy for enhancing milk performance. This supplement is recommended as a source of fat. Additionally, the implementation of decision‐making tools, such as the MADM method in animal science, can significantly improve management decision‐making processes by reducing both time and cost. This presents a new avenue for making well‐informed decisions.
Moments of multiplicity distributions for KNO scaling study using the ATLAS results
Authors: Kulchitsky Yuri A. , Tsiareshka Pavel 
Published: October 2023

Abstract
The normalised order-q moments of primarily charged-particle multiplicity distributions are studied for KNO scaling investigation in pp collisions as deduced from the results of the ATLAS at the LHC. The normalised moments for the LHC and low-energy experiments are compared for the kinematic region with an absolute pseudorapidity less than 2.5. The normalised moments show a increases linearly with centre-of-mass energies, and therefore the KNO scaling is violated for the full-scaled multiplicity region. The normalised moments for scaled multiplicity greater than one average multiplicity are constant for the highest centre-of-mass energies, and therefore the KNO scaling is concluded to hold.
Anwendung der Videosprechstunde in der kardiovaskulären Lipidbehandlung
Authors: Schuch A. , Walther P. , Timm L. , Steinbach K. , Haneklaus L. , Münzel T. , Prochaska J. H. , Wild P. S. 
Published: October 2023

Zusammenfassung
Hintergrund
Die Videosprechstunde ist eine Möglichkeit der ortsunabhängigen Arzt-Patienten-Kommunikation. Bei Möglichkeit der alleinigen Anwendung seit 2018 liegen jedoch nur eingeschränkte Informationen vor.

Methoden
Nach Einführung der Videosprechstunde (Viomedi) in der Lipidsprechstunde der Universitätsmedizin Mainz wurden die Patienten im Q1-2022 nach Möglichkeit, Eignung und Bereitschaft zur Durchführung bewertet. Hierbei wurden Lipidpatienten und Long-COVID-Patienten eingeschlossen. Nach Behandlung wurde eine Onlinebefragung zu Nutzung und Einschätzung durchgeführt.

Ergebnisse
29,1 % der 134 Patienten wurden eingeschlossen behandelt (3 Ablehnungen). Alle Probanden (16 Antworten) berichteten, (sehr) gut zurechtgekommen zu sein. Vorteile wurden in Beratung und Nachbeobachtung gesehen. Probleme wurden hinsichtlich Technik und möglicher Störungen befürchtet. Datenschutzaspekte spielten eine untergeordnete Rolle. Im Vergleich mit dem Telefonat wurde eine signifikante Verbesserung für das Arzt-Patienten-Verhältnis (p-Wert = 0,00027), die Behandlungs- und Informationsqualität (p-Wert jeweils = 0,00044), den Versorgungszugang (p-Wert = 0,0053) und die Kommunikation (p-Wert = 0,021) angenommen. Im Vergleich mit dem persönlichen Kontakt wurde eine Verbesserung des Versorgungszugangs (p-Wert = 0,021) und der Informationsqualität gesehen (p-Wert = 0,034). Als Hauptprobleme wurden fehlende Erfahrungen, technische Anforderungen, technische Probleme und fehlende Pünktlichkeit der Behandler angeführt. Gelobt wurden Flexibilität, geringer Aufwand und die angenehme Konsultation. Alle Probanden wollten die Videosprechstunde weiterhin nutzen.

Fazit
Die Videosprechstunde kann eine Ergänzung der Versorgung von Lipidpatienten darstellen. Die korrekte Nutzung erfordert eine exakte Planung und weitere Forschung.
Tipps und Tricks für die Zemententfernung im Revisionsfall
Authors: Meier Marc-Pascal , Hawellek Thelonius , Lehmann Wolfgang , von Lewinski Gabriela 
Published: October 2023

Zusammenfassung
Hintergrund
Aktuelle Re-Revisionsraten nach endoprothetischem Gelenkersatz liegen in Deutschland bei 28–37 %. Insbesondere verbliebende Zementreste sind für erneute Revisionseingriffen nach Sanierungsoperationen bei periprothetischen Infektionen ursächlich, weswegen die vollständige Zemententfernung von großer Bedeutung ist. Die Entfernung letzter Zementreste stellt den Operateur jedoch häufig vor technische Herausforderungen. Eine komplikationslose und vollständige Zemententfernung bedarf einer umfangreichen präoperativen Vorbereitung, um die bestmögliche Operationsstrategie zu entwickeln.

Therapie
Von verschiedenen Herstellern werden Spezialinstrumente angeboten, die die Zemententfernung im Revisionsfall erleichtern. Neben endoluminalen Zugängen existieren Zugangserweiterungen wie zusätzliche Osteotomien, welche die vollständige Zemententfernung erleichtern. Nicht zuletzt sollte der Operateur in der Lage sein, nach einem definierten Zeitintervall die Indikation zum intraoperativen Vorgehenswechsel zu stellen.