bluuebunny/crossref_metadata_2025_split huggingface dataset:
Statistical analysis of parameters and adsorption isotherm models
Authors: Pinto Felipe R. , Marcellos Caio F. C. , Camargo Carla L. Manske , Junior Amaro Gomes Barreto 
Published: October 2023

Abstract
The present work intends to discuss parameter estimation and statistical analysis in adsorption. The Langmuir and Toth isotherm models are compared for a set of carbon dioxide adsorption data on 13X zeolite from literature at different temperatures: 303, 323, 373, and 423 K. Statistical analyses were performed under frequentist and bayesian perspectives. Under the frequentist statistical view, the estimation of parameters was performed employing Maximum Likelihood estimation (MLE) using Particle Swarm Optimization (PSO) and a Newton-like method. Statistical analyses of parameters were performed by confidence regions in terms of elliptical approximation and likelihood region, while the evaluation of models was performed by chi-square statistics. The results showed the importance of precisely knowing the experimental errors and obtaining the true confidence region of model parameters. As the model is nonlinear, the elliptical confidence region provides a poor approximation of the confidence region of the parameter estimates. Finally, correlation matrices show that Toth’s equation returned less correlated parameters than the Langmuir’s. Under the bayesian perspective, the Markov-chain Monte Carlo (MCMC) technique allowed obtaining the confidence regions of the parameters such as those obtained by the frequentist approach. The bayesian method, however, enables the reconstruction of the parameters’ probability density functions and the propagation of parametric uncertainties.
Sustainability assessment of Low Earth Orbit (LEO) satellite broadband mega-constellations
Authors: Oughton Edward , Osoro Bonface , Wilson Andrew , Rao Akhil 
Published: October 2023

Abstract

The growth of mega-constellations is rapidly increasing the number of rocket launches required to place new satellites in space. While Low Earth Orbit (LEO) broadband satellites help to connect unconnected communities and achieve the Sustainable Development Goals, there are also a range of negative environmental externalities, from the burning of rocket fuels and resulting environmental emissions. We present sustainability analytics for phase 1 of the three main LEO constellations including Amazon Kuiper (3,236 satellites), OneWeb (648 satellites), and SpaceX Starlink (4,425 satellites). In baseline scenarios over five years, we find a per subscriber carbon dioxide equivalent (CO2eq) of 0.70±0.34 tonnes for Kuiper, 1.41±0.71 tonnes for OneWeb and 0.47±0.15 tonnes CO2eq/subscriber Starlink. However, in the worst-case emissions scenario these values increase to 3.02±1.48 tonnes for Kuiper, 1.7±0.71 tonnes for OneWeb and 1.04±0.33 tonnes CO2eq/subscriber for Starlink, more than 31-91 times higher than equivalent terrestrial mobile broadband. Importantly, phase 2 constellations propose to increase the number of satellites by an order-of-magnitude higher, highlighting the pressing need to mitigate negative environmental impacts. Strategic choices in rocket design and fuel options can help to substantially mitigate negative sustainability impacts.
Preventive effects of bioabsorbable anti-adhesion barriers on bowel obstruction after colectomy in colon cancer patients: a retrospective cohort study using an insurance claims database
Authors: Iwata Risa , Shuichi Mochizuki , Hasegawa Tomoaki , Ishii Kensuke , Matsumaru Naoki , Tsukamoto Katsura 
Published: October 2023

Abstract

Purpose
Postoperative adhesions can be prevented by the use of bioabsorbable anti-adhesion barriers. Patient-focused development is a worldwide requirement, but its implementation in medical device development is not sufficient. Although the occurrence of postoperative bowel obstruction is an important concern for patients, at the time of approval of anti-adhesion barriers, its effectiveness in preventing postoperative bowel obstruction had not been evaluated. We aimed to retrospectively evaluate the incidence of bowel obstruction after colectomy in patients with colon cancer using an insurance claims database.
Methods
This retrospective cohort study analyzed the data of colon cancer patients (between 2005 and 2017 from a national insurance claims database) who underwent colectomy to compare the proportion of individuals with postoperative bowel obstruction between the barrier and no barrier groups.
Results
Of the 587 patients who met the inclusion criteria, 308 and 279 patients were identified as the barrier and no barrier groups, respectively. The incidence of postoperative bowel obstruction was significantly lower in the barrier group (log-rank test, P = 0.0483). The cumulative incidence of postoperative bowel obstruction 37 months after the initial colectomy, was 6.1% and 10.9% in the barrier and no barrier groups, respectively.
Conclusion
In colectomy for patients with colon cancer, the use of anti-adhesion barriers could significantly reduce the incidence of postoperative bowel obstruction. Evaluations using insurance claims databases could provide important information to achieve patient-focused evaluation of medical devices.
A case report of an atypical severe case of skin picking disorder managed by a multidisciplinary team
Authors: LeBlanc Marissa A. , Hudec Mary-Ann , Weise Lutz 
Published: October 2023

Abstract
Background: While skin picking disorder remains relatively common, it often does not present to psychiatry until significant morbidity or comorbidities are reached. It is described as recurrent picking of skin leading to skin lesions, with repeated attempts to decrease or stop skin picking. It is also often associated with significant distress or functional impairment. There has been limited research in this specific disorder and treatment efficacy has often been poor in severe cases. For various reasons, only a small amount of patients with this disorder present to care, and often to a multidisciplinary team prior to psychiatry.
Case Presentation: This is a case presentation of a 44 year old male with a complex past psychiatric history, ultimately untreated for an underlying skin picking disorder. He presented for urgent medical care following a self-inflicted wound through the central frontal bone and dura over the course of 2 years. He was treated with current psychiatric evidence based medicine, including an SSRI, antipsychotic augmentation and NAC, along with habit reversal techniques during the admission. He was concurrently managed with the neurosurgery team, initially with a poor prognosis due to the severity of his presentation. He required debriding of the devitalized bone within the adjacent brain to cover the dural defect, IV antibiotics for 6 weeks, and an initial skin graft on his initial admission.
Conclusions: This case in particular highlighted the importance of urgent treatment via a multidisciplinary approach to avoid mortality. It highlights the importance of increasing awareness about the disorder and that treatment with SSRI’s, along with antipsychotic and NAC adjuncts remains the mainstay of acute treatment.
Anti-CASPR2 encephilitis patients present with depression as the first diagnostic feature
Authors: Qin Xiaohong , He Yunsen , Zhong Xuemei , jiang Fugui , Luo Yuanyuan , Liu Xuemei , Wu Bo , Zhang Mengjun , Guo Lili , Xiao Jun , Li Jieying 
Published: October 2023

Abstract
Background and Purpose Although depression has been reported in patients with anti-contact protein-associated protein-2 (CASPR2) encephalitis, it rarely occurs as the first diagnostic feature in these patients, and it can be easily missed or misdiagnosed as a psychiatric disorder. This study evaluated the clinical features and pathogenesis of depression in patients with anti-CASPR2 encephalitis.Methods This was a prospective study in which patients with anti-CASPR2 encephalitis and co-current depression were recruited. Between 2020 and 2022, demographic data, clinical manifestations, Self-rating Depression scale (SDS), Self-rating Anxiety Scale(SAS), and antibody levels in cerebrospinal fluid (CSF) and serum of 6 patients with depression as the first manifestation were collected and analyzed.Results A total of 23 anti-CASPR2 encephalitis patients with depression and six patients (five females) with anti-CASPR2 encephalitis and depression as the first presentation were recruited in the present study. All patients showed subacute onset and were misdiagnosed with psychiatric disorders, with depression as the first symptom, accompanied by anxiety and cognitive impairment, and autonomic dysfunction. Good response to immunotherapy. After a follow-up for 6 months, all symptoms were significantly alleviated, and the anti-CASPR2 antibodies were negative.Conclusion Depression, as the first manifestation of anti-CASPR2 encephalitis, is more common in middle-aged and older women. The most common subtypes of depression are anxiety-distress, often accompanied by cognitive and autonomic disorders. A single serum antibody may improve the diagnosis of patients. Therefore, immunotherapy is an effective treatment modality. Immune activation is potentially the pathogenesis of depressive disorders in patients with anti-CASPR2 encephalitis.
Preparation of PDA-GO/CS Composite Scaffold and Its Effects on Biological Properties of Human Dental Pulp Stem Cells
Authors: li yaoyao , huang xinhui , fu weihao , zhang zonghao , xiao kuancheng , lv hongbing 
Published: October 2023

Abstract
Objective: PDA-GO polymers combining polydopamine (PDA) and graphene oxide(GO)were prepared. Combining different masses of PDA-GO with chitosan (CS) to synthesize PDA-GO/CS composite scaffolds with different mass fractions. The antibacterial and physicochemical properties of PDA-GO/CS composite scaffolds with different mass fractions were detected to screen the optimal mass fraction. Test the biocompatibility of composite scaffolds and their effects on the proliferation, migration, and osteogenic differentiation of human dental pulp stem cells (hDPSCs).
Methods: The surface functional groups of the materials were detected using Fourier-transform infrared spectroscopy (FTIR).The optimal mass fraction for PDA-GO was screened by antibacterial experiment, observation of scaffold surface morphology and physicochemical performance test. The composite scaffolds were cultured with hDPSCs. By analyzing the biological effects on the proliferation, migration and osteogenic differentiation of hDPSCs, the biological properties of the composite scaffolds were further investigated.
Results: FTIR showed that the oxygen-containinggroups of PDA-GO reduced compared with GO, and new groups were produced in PDA-GO/CS compared with GO/CS. The count colony forming units of the 0.3% PDA-GO/CS group decreased, the pore size and porosity met the requirements of bone tissue engineering scaffolds, the swelling ratio increased, and the degradation rate decreased.The migration ability of the 0.3% PDA-GO/CS group was higher than that of the control group, while ALP staining and alizarin red staining were deeper than those of the blank control group. Real time fluorescence quantitative PCR results showed that the 0.3%PDA-GO/CS group showed an increase in osteogenic gene expression compared to the control group.
Conclusions: Successfully prepared PDA-GO/CS composite scaffold.0.3%PDA-GO/CS scaffolds improves the antibacterial activity and hydrophilicity of CS, while reducing the degradation rate. In vitro, 0.3%PDA-GO/CS has superior biocompatibility and promote the early proliferation, migration and osteogenic differentiation of hDPSCs.
Evaluation of pharmacy residency program in West China Hospital with reference to ASHP resident certification standard
Authors: Wang Zhidan , Chen Zhaoyang , Huang Zijia , Wang Shiyan , Li Yuwen , Zhang Ting 
Published: October 2023

Abstract
Background: In hospitals in China, clinical pharmacist is a developing profession. Standardized training is necessary before becoming clinical pharmacists. How to do a good job in the standardized training of clinical pharmacists is a topic that has been discussed. Carrying out strategies that are compatible to the current situation of pharmaceutics in China is expected to promote the residency training program. In this study, we compared the current pharmacy residency model of West China Hospital (WCH) and the American Society of Health-System Pharmacists (ASHP)residency accreditation standards.
Methods: By reviewing literature and official documents, the model of WCH and the ASHP residency accreditation standards were retrospectively compared, the differences were analyzed, and constructive suggestions were put forward for the training of pharmacists in China.
Results: There are some similarities between the model of WCH and the ASHP residency accreditation, but there are also some differences. Although we have the same two-year training as the United States, due to the diversity of the domestic medical environment, there are certain differences between the two sides in various aspects. It can be seen from the differences in domestic and foreign environment, development process, training standards, training contents and training personnel's academic qualifications.
Conclusions: The training model of clinical pharmacists in our hospital has many positive points, which is worth learning for other hospitals in China. In addition, there are also some shortcomings. In the future, we will continue to refer to the ASHP residency accreditation standards to improve our training model and enhance the training capacity of clinical pharmacists.
Experimental study MMP10 Regulates the lymph node metastasis of Oral Squamous Cell Carcinoma Cells
Authors: Qu Jing , Wu Xiaoting , Lan Ting , Zheng Dali , Lu YouGuang , Gan Ruihuan , Ding Lincan 
Published: October 2023

Abstract

Aberrant MMP expression can be detected in almost all primary and recurrent tumors. The aim of this study was to identify the role of MMP10 in the cell biological function of OSCC. We analyzed the expression and survival data analysis were done using data from the Cancer Genome Atlas (TCGA) and the Clinical Proteomic Tumor Analysis Consortium(CPTAC) database, then expression of MMP10 in clinical OSCC samples was detected by using qRT-PCR. We reduced the expression of MMP10 to elucidate the effects of MMP10 on proliferation, migration and invasion. Genes associated with MMP10 were validated by qRT-PCR. The MMP10 expression was raised in HNSC and OSCC, and the high MMP10 expression in HNSC with a poor prognosis outcome. The MMP10 expression was upregulated in OSCC tissues when compared with adjacent tissues. Knockdown the expression of MMP10 inhibited the cell migration and invasion in vitro and lymph node metastasis in vivo. And the expression of MMP10 was regulated by WNT3A. The results of present study indicate that MMP10 plays a significant role in the invasion and migration of OSCC. MMP10 may be a possible target gene for the therapy of OSCC by inhibiting metastasis.
Loss of noggin1, a Classic Embryonic Inducer Gene, in Elasmobranchs
Authors: Bayramov Andrey , Ermakova Galina , Meyntser Irina , Zaraisky Andrey 
Published: October 2023

Abstract
Secreted proteins of the Noggin family serve as pivotal regulators of early development and cell differentiation in all multicellular animals, including vertebrates. Noggin1 was identified first among all Noggins. Moreover, it was described as the first known embryonic inducer specifically secreted by the Spemann organizer and capable of inducing a secondary body axis when expressed ectopically. In the classical default model of neural induction, Noggin1 is presented as an antagonist of BMP signalling, playing a role as a neural inducer. Additionally, Noggin1 is involved in the dorsalization of embryonic mesoderm and later controls the differentiation of various tissues, including muscles, bones, and neural crest derivatives. Hitherto, Noggin1 was found in all studied vertebrates. Here, we report the loss of noggin1in elasmobranchs (sharks, rays and skates), which is a unique case among vertebrates. noggin2 and noggin4 retained in this group and studied in the embryos of the grey bamboo shark Chiloscyllium griseum revealed similarities in expression patterns and functional properties with their orthologues described in other vertebrates. The loss of noggin1 in elasmobranchs may be associated with histological features of the formation of their unique internal cartilaginous skeleton, although additional research is required to establish functional connections between these events.
An immune-competent human gut microphysiological system enables inflammation-modulation of Faecalibacterium prausnitzii
Authors: Zhang Jianbo , Huang YuJa , Trapecar Martin , Wright Charles , Schneider Kirsten , Kemmit John , Hernandez-Gordillo Victor , Griffith Linda , Alm Eric , Trumper David , Yoon Jun Young , Breault David 
Published: October 2023

Abstract
Crosstalk of microbes with human gut epithelia and immune cells is crucial for gut health. However, there is no existing system for a long-term co-culture of human innate immune cells with epithelium and oxygen-intolerant commensal microbes, hindering the understanding of microbe-immune interactions in a controlled manner. Here, we establish a gut epithelium-microbe-immune microphysiological system to maintain the long-term continuous co-culture of Faecalibacterium prausnitzii/Faecalibacterium duncaniae with colonic epithelium, antigen-presenting cells (APCs, herein dendritic cells and macrophages), with CD4+ naïve T cells circulating underneath the colonic epithelium. Multiplex cytokine assays suggested that APCs contribute to the elevated level of cytokines and chemokines being secreted into both apical and basolateral compartments. In contrast, the absence of APCs does not allow reliable detection of these cytokines. In the presence of APCs, F. prausnitzii increased the transcription of pro-inflammatory genes such as toll-like receptor 1 (TLR1) and interferon alpha 1 (IFNA1) in the colonic epithelium, but no significant change on the secreted cytokines. In contrast, integration of CD4+ naïve T cells reverses this effect by decreasing the transcription of TLR1, IFNA1, and indoleamine 2,3-dioxygenase, and increasing the F. prausnitzii-induced secretion of pro-inflammatory cytokines such as IL-8, MCP-1/CCL2, and IL1A. These results highlight the contribution of individual innate immune cells in the regulation of the immune response triggered by the gut commensal F. prausnitzii. The successful integration of defined populations of immune cells in this gut microphysiological system demonstrated the usefulness of the GuMI physiomimetic platform to study microbe-epithelial-immune interactions in health and disease.
Evaluation of results agreement of integrated visual and auditory continuous performance test in attention deficit hyperactivity disorder children with Conners' parent test after treatment with methylphenidate
Authors: Heydari Azamossadat , Ghasempour Sare , Moharreri Fatemeh , Akhlaghi Saeed , Khoshkbarchi Masoomeh , Honari Sara 
Published: October 2023

Abstract
Introduction: Attention deficit hyperactivity disorder (ADHD) is a neurodevelopmental disorder. Two methods to diagnose ADHD are to use cognitive tests such as the Integrated Visual and Auditory (IVA) continuous performance (CPT) and the Conners' parent tests. In this study, a new method under IVA-CPT was investigated on ADHD children, and the degree of synchronization with the Connors test of parents was measured. Method: This study was conducted with a pretest-posttest design. Twenty ADHD patients were evaluated to enroll. The patients received methylphenidate® at a dose of 60 mg/day for six weeks. Before and after treatment, subjects were examined with IVA-CPT test. After the sixth week, the rate of response to treatment and improvement of the patients was also evaluated by the Conners' parent test. Results: The mean age was 10.30 ± 2.5 and 55% of patients were boys. none of the Conners' parent and IVA-CPT test scores had a substantial agreement before, during, and after the intervention. Furthermore, there was no significant agreement between the diagnosis based on the Conners' parent scale and the IVACPT test before (p = 0.969) and after (p = 0.917) treatment. Conclusion: The results of the present study showed that there is no significant agreement between the diagnosis of ADHD based on the Conners' parent scale and the CPT-IVA test before and after treatment with methylphenidate. Also, no significant relationship was observed between the subscales of these two tests. These results suggest that physicians should expect to find a lack of consistency between the scores provided by these measures and should be conservative of their use in clinical settings.
Application of Deep Learning and Feature Selection Technique on External Root Resorption Identification on CBCT Images
Authors: Reduwan Nor Hidayah , Aziz Azwatee Abdul , Razi Roziana Mohd , Abdullah Erma Rahayu Mohd Faizal , Nezhad Seyed Matin Mazloom , Gohain Meghna , Ibrahim Norliza 
Published: October 2023

Abstract
Background: Artificial intelligence have been proven to improve the identification of various maxillofacial lesions. The aim of the current study is two-fold, to assess the performance of four deep learning models (DLM) in external root resorption (ERR) identification, and to assess the effect of combining feature selection technique (FST) with DLM on their ability in ERR identification.
Methods: External root resorption was simulated on 88 extracted premolar teeth using tungsten bur according to different depths (0.5mm, 1mm and 2mm). All teeth were scanned using a Cone beam CT (Carestream Dental-CHECK). A training (70%), validation (10%), and test (20%) dataset were established. The performance of four DLMs (i. Random Forest (RF)+Visual Geometry Group 16 (VGG), ii. RF+EfficienNetB4 (EFNET), iii. Support Vector Machine (SVM)+VGG and iv. SVM+EFNET) and four hybrid models (DLM+FST: i. FS+RF+VGG, ii. FS+RF+EFNET, iii. FS+SVM+VGG and iv. FS+SVM+EFNET) was compared. Five performance parameters were assessed namely classification accuracy, F1-score, precision, specificity, error rate. FST algorithms (Boruta and Recursive Feature Selection) were combined with the DLMs to assess their performance.
Result: RF+VGG exhibited the highest performance in identifying ERR followed by the other tested models. Similarly, FST combined with RF+VGG outperformed other models with classification accuracy, F1-score, precision, and specificity of 81.9%, weighted accuracy of 83%, and AUC of 96%.
Conclusion: In general, all DLMs have similar performance on ERR identification. However, the performance can be improved by combining FST with DLMs.