bluuebunny/crossref_metadata_2025_split huggingface dataset:
Psychological inoculation strategies to fight climate disinformation across 12 countries
Authors: Spampatti Tobia , Hahnel Ulf J. J. , Trutnevyte Evelina , Brosch Tobias 
Published: November 2023

AbstractDecades after the scientific debate about the anthropogenic causes of climate change was settled, climate disinformation still challenges the scientific evidence in public discourse. Here we present a comprehensive theoretical framework of (anti)science belief formation and updating to account for the psychological factors that influence the acceptance or rejection of scientific messages. We experimentally investigated, across 12 countries (N = 6,816), the effectiveness of six inoculation strategies targeting these factors—scientific consensus, trust in scientists, transparent communication, moralization of climate action, accuracy and positive emotions—to fight real-world disinformation about climate science and mitigation actions. While exposure to disinformation had strong detrimental effects on participants’ climate change beliefs (δ = −0.16), affect towards climate mitigation action (δ = −0.33), ability to detect disinformation (δ = −0.14) and pro-environmental behaviour (δ = −0.24), we found almost no evidence for protective effects of the inoculations (all δ < 0.20). We discuss the implications of these findings and propose ways forward to fight climate disinformation.
Risk factors for templating mismatch of uncemented stems in bipolar hemiarthroplasty for femoral neck fracture
Authors: Kim Han Soul , Cho Sung Ha , Moon Dou Hyun , Kim Chul-Ho 
Published: November 2023

AbstractPreoperative templating needs to be precise to optimize hip arthroplasty outcomes. Unexpected implant mismatches can occur despite meticulous planning. We investigated the risk factors for oversized and undersized stem mismatch during uncemented hemiarthroplasty using a double-tapered wedge rectangular stem for femoral neck fracture. Out of 154 consecutive patients who underwent hemiarthroplasty for femoral neck fracture, 104 patients were divided into three groups: (1) oversized (n = 17; 16.3%), (2) matched (n = 80; 76.9%), and (3) undersized stem group (n = 7; 6.7%). A smaller femoral head offset (odds ratio [OR] = 0.89, 95% confidence interval [95% CI] = 0.81–0.98, P = 0.017), smaller isthmus diameter (OR = 0.57, 95% CI = 0.35–0.92, P = 0.021), and smaller canal flare index (OR = 0.20, 95% CI = 0.04–0.98, P = 0.047) were significantly associated with oversized stem insertion, while older age (OR = 1.18, 95% CI = 1.01–1.39, P = 0.037) was associated with undersized stem insertion in logistic regression. In conclusion, when performing hemiarthroplasty for a femoral neck fracture with a double-tapered wedge rectangular stem, surgeons must pay close attention to proximal femoral geometry and patient age during preoperative planning to avoid stem mismatch.
An efficient hexadecimal network flow watermark method for tracking attack traffic
Authors: Cui Jun , Han Keya , Sha Lin , Liu Wei , Zhang Xiaofeng , Li Guangxu 
Published: November 2023

AbstractNetwork flow watermark technology is a traffic marking technique that embeds watermark information into the characteristics of network flows to mark and trace attack flows generated by network attackers. However, with the development of network attack techniques, the time and number of packets required for network attacks have decreased. Existing network flow watermark technologies fail to balance watermark robustness and efficiency, resulting in poor practicality. To address this issue, this paper proposes an efficient hexadecimal network flow watermark method. The method introduces an efficient interval watermark algorithm and utilizes an interval synchronization algorithm to self-learn watermark parameters, thereby improving the encoding efficiency of the watermark. The design of watermark start and end markers ensures the practicality of network watermarks, enabling traceability and source attribution of attack flows in real network environments. The proposed method is experimentally tested using real network traffic, and the results demonstrate that even in the presence of a network jitter, the watermark detection success rate of this scheme remains above 95%. Compared to other network flow watermark schemes, the hexadecimal network flow watermark proposed in this paper achieves a 50% improvement in encoding and decoding efficiency while ensuring robustness. It also exhibits excellent resistance to network jitter, packet loss, and false packet insertion.
S-index periodicity detection based on multiple random spectral observations
Authors: Shen Yu-Fu 
Published: November 2023

AbstractThe solar magnetic activity cycle has a profound impact on our lives, yet its underlying causes remain elusive. While similar cycles have been observed in other stars, these results are scarce due to the significant challenge posed by the length of time required for observation. Continuous observation over an extended period is a luxury, making it difficult to gather large samples. However, multiple random observations can be made at a lower cost, and flexible time management enables non-professionals to become competent. In this study, we analyzed multiple random observations of the S-indices of several stars captured incidentally by the Large Sky Area Multi-Object Fiber Spectroscopic Telescope. Our findings reveal potential periodicity that could be associated with magnetic activity cycles. Notably, obtaining S-index is relatively less challenging, indicating the feasibility of developing dedicated commercial or charitable equipment for non-astronomers. A more extensive data is essential to establish a definitive correlation between S-index periodicity and magnetic activity cycles in stars, as well as to uncover additional magnetic activity cycles.
Design study of the collection optics for Polarimetric Thomson Scattering on ITER
Authors: Den Hartog D.J. , Thomas M.A. 
Published: November 2023

Abstract
The ITER Core Plasma Thomson Scattering (CPTS) system is the primary diagnostic for the electron temperature (Te
) and electron density (ne
) profiles. For high performance ITER operating scenarios in which core Te
> 20 keV, the conventional spectral CPTS will not provide measurement accuracy sufficient for advanced machine control. Addition of polarimetric measurement capability to the CPTS diagnostic is projected to increase measurement accuracy in high temperature/low density plasmas to required levels. To determine the feasibility of Polarimetric TS implementation on ITER, the polarization characteristics of the CPTS scattered light collection system have been modeled as part of a conceptual design study. When linearly polarized light is propagated through the CPTS collections optics, polarization is rotated and ellipticized. This characteristic of the ITER collection optical system complicates separation and analysis of the depolarized component of the Thomson scattered light that is produced at high Te
. To address this challenge, a custom waveplate and polarizing beamsplitter should be mounted before the final lens in the CPTS collection optical system. Additionally, polarization performance should be one of the criteria by which materials and coatings are selected for the CPTS collection optical system.
Highly energy efficient housing can reduce peak load and increase safety under beneficial electrification
Authors: Maxim Alexandra , Grubert Emily 
Published: November 2023

Abstract
Climate change is driving urgent investments in decarbonization. One core decarbonization strategy is to electrify energy services that currently directly use fossil fuels, because electricity can be generated from zero greenhouse gas energy resources. Shifting fossil-based services to electricity, however, requires a major expansion of electricity supply and increases dependence on electricity for critical services. Home heating is a particular challenge, especially in very cold climates. Unserved heating loads can be fatal. Electrified heating is expected to drive peak loads (and thus overall grid size) due to high coincident and nondeferrable loads. This study shows that highly efficient housing presents an opportunity to simultaneously protect people and structurally reduce peak load, reducing the need for electricity supply infrastructure while increasing people’s resilience to weather extremes. This study uses seven building efficiency scenarios from the National Renewable Energy Laboratory’s End Use Saving Shapes to investigate the impact of residential building efficiency on grid size in 2050, using the example of Pierre, South Dakota as a very cold weather location that might also experience substantial new housing demand due to climate-induced human mobility. We find that the deepest efficiency electrification scenario we investigate reduces peak demand by about half relative to low-efficiency electrification. Costs of about $3900/kilowatt (kW) peak load reduction are competitive with the cost of new decarbonized supplies capable of meeting peak load, though building efficiency costs are usually privatized while supply expansion costs are distributed across ratepayers. Decarbonization scenarios suggest the US grid might need to expand by a factor of 5–8 in the next 25 years: extremely rapid growth will be needed regardless, but targets might not be reachable with inefficient end users. Residential building efficiency presents an urgent opportunity to reduce peak demand and provide safer and more resilient housing.
Insights from exact social contagion dynamics on networks with higher-order structures
Authors: Kiss István Z , Iacopini Iacopo , Simon Péter L , Georgiou Nicos 
Published: November 2023

Abstract
Recently, there has been an increasing interest in studying dynamical processes on networks exhibiting higher-order structures, such as simplicial complexes, where the dynamics acts above and beyond dyadic interactions. Using simulations or heuristically derived epidemic spreading models, it was shown that new phenomena can emerge, such as bi-stability/multistability. Here, we show that such new emerging phenomena do not require complex contact patterns, such as community structures, but naturally result from the higher-order contagion mechanisms. We show this by deriving an exact higher-order Susceptible-Infected-Susceptible model and its limiting mean-field equivalent for fully connected simplicial complexes. Going beyond previous results, we also give the global bifurcation picture for networks with 3- and 4-body interactions, with the latter allowing for two non-trivial stable endemic steady states. Differently from previous approaches, we are able to study systems featuring interactions of arbitrary order. In addition, we characterize the contributions from higher-order infections to the endemic equilibrium as perturbations of the pairwise baseline, finding that these diminish as the pairwise rate of infection increases. Our approach represents a first step towards a principled understanding of higher-order contagion processes beyond triads and opens up further directions for analytical investigations.
Epigenetic changes induced by pathogenic Chlamydia spp
Authors: Stein Richard A , Thompson Lily M 
Published: November 2023

Abstract
Chlamydia trachomatis, C. pneumoniae, and C. psittaci, the three Chlamydia species known to cause human disease, have been collectively linked to several pathologies, including conjunctivitis, trachoma, respiratory disease, acute and chronic urogenital infections and their complications, and psittacosis. In vitro, animal, and human studies also established additional correlations, such as between C. pneumoniae and atherosclerosis and between C. trachomatis and ovarian cancer. As part of their survival and pathogenesis strategies as obligate intracellular bacteria, Chlamydia spp. modulate all three major types of epigenetic changes, which include deoxyribonucleic acid (DNA) methylation, histone post-translational modifications, and microRNA-mediated gene silencing. Some of these epigenetic changes may be implicated in key aspects of pathogenesis, such as the ability of the Chlamydia spp. to induce epithelial-to-mesenchymal transition, interfere with DNA damage repair, suppress cholesterol efflux from infected macrophages, act as a co-factor in human papillomavirus (HPV)-mediated cervical cancer, prevent apoptosis, and preserve the integrity of mitochondrial networks in infected host cells. A better understanding of the individual and collective contribution of epigenetic changes to pathogenesis will enhance our knowledge about the biology of Chlamydia spp. and facilitate the development of novel therapies and biomarkers. Pathogenic Chlamydia spp. contribute to epigenetically-mediated gene expression changes in host cells by multiple mechanisms.
Young people’s attitudes to Pre-Exposure Prophylaxis for HIV Prevention – a qualitative exploratory study
Authors: Rathbone A P , Cartwright N , Noble R , Cumming L , Budaiova K , Ashton M , Foster J , Payne B , Duncan S 
Published: November 2023

Abstract

Introduction
Young people aged 18-24 years old are a key demographic target for eliminating human immunodeficiency virus (HIV) transmission globally. Pre-exposure prophylaxis (PrEP), a prevention medication which reduces HIV transmission, is emerging as a key tool to reduce HIV transmission. Despite largely good uptake by gay and bisexual men who have sex with men, hesitancy to use PrEP has been observed in other socio-cultural groups, such as young people, heterosexuals, people from ethnic minority backgrounds and females.

Aim
The aim of this study was to explore young peoples’ perceptions and attitudes to using PrEP.

Methods
A convenience sample of young people were recruited from England aged between 18 and 24 using a social media invitation posted by two authors which include details about the study with a registration link. Data was collected using semi-structured one-to-one interviews with graphic elicitation about current experiences of HIV care, awareness of using PrEP and decision making about accessing PrEP. Thematic analysis was used to identify codes and themes to describe participants’ experiences. Institutional ethical approval was obtained.

Results
Twenty-four young people took part. The sample was 58% female, 100% cisgendered, 54% had or were completing undergraduate study, 58% were straight, 58% had previously had a HIV test, 17% had previously used PrEP and a broad range of ethnicity were included. Key findings found young people had good levels of knowledge about HIV but had a poor understanding of using PrEP. In this information vacuum, negative stigma and stereotypes about HIV were transferred to using PrEP, which were reinforced by information on social media, television, and film - such as an association between using PrEP and being a promiscuous, white, gay males. In addition, young people from ethnic ethnicity communities appeared to have particularly negative attitudes to PrEP use, compared to ethnic majority counterparts. This meant the young people in our study were unable to make decisions about when to access and use PrEP.

Discussion/Conclusion
The findings indicate an information vacuum for young people regarding PrEP. A strength of the study is that theoretical data saturation was reached. A limitation of the study is that participants were all cisgendered and therefore the experiences of young trans people were not accounted for. Further work is needed to explore what information young people need, when and how this can be delivered to support informed decision-making about using PrEP. Pharmacists have a key role in supporting sexual health and further work should explore community pharmacies readiness to provide this information to young people.
Medial Patellofemoral Ligament Reconstruction With or Without Tibial Tubercle Osteotomy in Carefully Selected Patients Results in a 5% Revision Rate: A Preliminary Analysis
Authors: Perkins Crystal A. , Egger Anthony C. , Busch Michael T. , Murata Asahi , Willimon Samuel C. 
Published: November 2023

Purpose:
The purpose was to assess the outcomes of medial patellofemoral ligament (MPFL) allograft reconstruction with or without tibial tubercle osteotomy (TTO) in adolescents, with a focus on evaluating demographic and imaging characteristics on outcomes.

Methods:
A single-institution retrospective study was performed of patients ages 12 to 19 years who underwent MPFL reconstruction +/− TTO for the treatment of lateral patellar instability. Demographic, clinical, surgical, and postoperative information was collected. All x-ray and magnetic resonance imaging measurements were completed independently by 2 surgeons. Patients were contacted to complete patient-reported outcomes at a minimum of 2 years following surgery. The primary outcome measure was recurrent instability resulting in revision surgery.

Results:
Seventy-eight knees in 74 patients, with a median age of 15.3 years (interquartile range: 14.4, 16.1), were included. Forty-five knees underwent isolated MPFL reconstruction and 33 knees had a combined MPFL + TTO. The knees that underwent MPFL + TTO had significantly greater tibial tubercle-trochlear groove distance (19.0 mm vs. 15.4 mm, P=0.015) and patellar tendon-lateral trochlear ridge distance (10.9 mm vs. 5.9 mm, P=0.018) than the knees treated with isolated MPFL reconstruction. Four knees (5.1%) underwent revision stabilization surgery, including 3 knees in the MPFL cohort (6.7%) and 1 knee in the MPFL + TTO cohort (3.0%). The rate of failure between the MPFL and MPFL + TTO knees was not significantly different, P=0.634. There were no differences in age, sex, body mass index, number of dislocations, or any imaging characteristics in patients who underwent revision versus those who did not. Patient-reported outcomes were collected on 50 knees at a median of 36 months (interquartile range: 24, 54) after surgery, and no differences were noted between cohorts.

Conclusions:
Patellar stabilization surgery, including MPFL reconstruction and TTO in carefully selected patients, had excellent revision-free outcomes in 95% of this adolescent cohort. In this case series, those patients whose treatment included TTO had greater tibial tubercle-trochlear groove and patellar tendon-lateral trochlear ridge as compared to the isolated MPFL cohort. Despite previous literature suggesting demographic and imaging characteristics as risks for recurrent instability, we identified no characteristics within these two distinct surgical treatment groups to be predictive of the need for revision stabilization, regardless of the treatment group.

Level of Evidence:
Level III—retrospective comparison study
Definition, prediction, prevention and management of patients with severe ischemic stroke and large infarction
Authors: Hua Xing , Liu Ming , Wu Simiao 
Published: November 2023

Abstract
Severe ischemic stroke carries a high rate of disability and death. The severity of stroke is often assessed by the degree of neurological deficits or the extent of brain infarct, defined as severe stroke and large infarction, respectively. Critically severe stroke is a life-threatening condition that requires neurocritical care or neurosurgical intervention, which includes stroke with malignant brain edema, a leading cause of death during the acute phase, and stroke with severe complications of other vital systems. Early prediction of high-risk patients with critically severe stroke would inform early prevention and treatment to interrupt the malignant course to fatal status. Selected patients with severe stroke could benefit from intravenous thrombolysis and endovascular treatment in improving functional outcome. There is insufficient evidence to inform dual antiplatelet therapy and the timing of anticoagulation initiation after severe stroke. Decompressive hemicraniectomy (DHC) <48 h improves survival in patients aged <60 years with large hemispheric infarction. Studies are ongoing to provide evidence to inform more precise prediction of malignant brain edema, optimal indications for acute reperfusion therapies and neurosurgery, and the individualized management of complications and secondary prevention. We present an evidence-based review for severe ischemic stroke, with the aims of proposing operational definitions, emphasizing the importance of early prediction and prevention of the evolution to critically severe status, summarizing specialized treatment for severe stroke, and proposing directions for future research.
Reasons, safety and efficacy analysis for conversion of HAART to TAF/FTC/BIC among HIV-infected patients
Authors: Xiao Jiang , Gao Guiju , Ding Yi , Li Jialu , Gao Chengyu , Xu Qiuhua , Wu Liang , Liang Hongyuan , Ni Liang , Wang Fang , Duan Yujiao , Yang Di , Zhao Hongxin 
Published: November 2023

Abstract

Background:
This study aimed to determine the reasons for conversion and elucidate the safety and efficacy of transition to tenofovir alafenamide/emtricitabine/bictegravir sodium (TAF/FTC/BIC) in highly active antiretroviral therapy (HAART)-experienced HIV-infected patients in real-world settings.

Methods:
We conducted a retrospective cohort study. The treatment conversion rationales, safety, and effectiveness in 1684 HIV-infected patients with previous HAART experience who switched to TAF/FTC/BIC were evaluated at Beijing Ditan Hospital from September 2021 to Auguest 2022.

Results:
Regimen simplification (990/1684, 58.79%) was the most common reason for switching, followed by osteoporosis or osteopenia (375/1684, 22.27%), liver dysfunction (231/1684, 13.72%), decline in tenofovir alafenamide/emtricitabine/elvitegravir/cobicistat (TAF/FTC/EVG/c) with food restriction (215/1684, 12.77%), virological failure (116/1684, 6.89%), and renal dysfunction (90/1684, 5.34%). In patients receiving non-nucleotide reverse transcriptase inhibitors (NNRTI)-containing regimens, lipid panel changes 1 year after switching indicated a difference of 3.27 ± 1.10 mmol/L vs. 3.40 ± 1.59 mmol/L in triglyceride (P = 0.014), 4.82 ± 0.74 mmol/L vs. 4.88 ± 0.72 mmol/L in total cholesterol (P = 0.038), 3.09 ± 0.70 mmol/L vs. 3.18 ± 0.66 mmol/L in low-density lipoprotein (P <0.001), and 0.99 ± 0.11 mmol/L vs. 0.95 ± 0.10 mmol/L in high-density lipoprotein (P <0.001). Conversely, among patients receiving booster-containing regimens, including TAF/FTC/EVG/c and lopinavir/ritonavir (LPV/r), lipid panel changes presented decreased trends. We also observed an improved trend in viral load suppression, and alanine transaminase (ALT), aspartate transaminase (AST), estimated glomerular filtration rate (eGFR), and serum creatinine levels after the transition (P <0.001).

Conclusion:
The transition to TAF/FTC/BIC demonstrated good treatment potency. Furthermore, this study elucidates the motivations behind the adoption of TAF/FTC/BIC in real-world scenarios, providing clinical evidence supporting the stable conversion to TAF/FTC/BIC for HAART-experienced patients.