bluuebunny/crossref_metadata_2025_split huggingface dataset:
Preserving What Matters: Longitudinal Changes in Control Over Interpersonal Stress and Noninterpersonal Stress in Daily Life
Authors: Cerino Eric S , Charles Susan T , Piazza Jennifer R , Rush Jonathan , Looper Ashley M , Witzel Dakota D , Mogle Jacqueline , Almeida David M 
Published: February 2024

Abstract

Objectives
Theoretical perspectives on aging suggest that when people experience declines in later life, they often selectively focus on maintaining aspects of their lives that are most meaningful and important to them. The social domain is one of these selected areas. The current study examines people’s reports of control over their daily stressors over 10 years, predicting that the declines in control that are often observed in later life will not be observed for stressors involving interpersonal conflict and tensions with social partners.

Methods
Adults ranging from 35 to 86 years old at baseline (N = 1,940), from the National Study of Daily Experiences, reported control over interpersonal and noninterpersonal daily stressors across 8 consecutive days at 2 time points, about 10 years apart.

Results
Findings from multilevel models indicate that for noninterpersonal stressors, perceived control decreased over time. In contrast, perceived control over interpersonal conflicts and tensions remained robust over time. No cross-sectional baseline age differences were found for levels of interpersonal and noninterpersonal stressor control.

Discussion
Results are consistent with socioemotional selectivity and underscore the importance of interpersonal relationships in later adulthood. Understanding how people select and preserve certain aspects of control in their daily life can help guide efforts toward maximizing gains and minimizing losses in domains that matter most to people as they grow older.
Near-source effects on DAS recording: implications for tap tests
Authors: Kennett B L N , Lai V H , Miller M S , Bowden D , Fichtner A 
Published: February 2024

SUMMARY
In the immediate vicinity of a source, there are strong gradients in the seismic wavefield that are tamed and modified in distributed acoustic sensing (DAS) recording due to combined effects of gauge-length averaging and local stacking on the local strain field. Close to a source broadside propagation effects are significant, and produce a characteristic impact on the local DAS channels. In the presence of topography, of surface or cable, additional effects are introduced that modify the expected signal. All these influences mean that the results of tap tests used to calibrate the channel positions along a DAS cable may give a distorted view of the actual geometry. Such effects can be important for detailed mapping of faulting processes and comparable features.
CarbDisMut: database on neutral and disease-causing mutations in human carbohydrate-binding proteins
Authors: Shanmugam N R Siva , Kulandaisamy A , Veluraja K , Gromiha M Michael 
Published: February 2024

Abstract
Protein-carbohydrate interactions are involved in several cellular and biological functions. Integrating structure and function of carbohydrate-binding proteins with disease-causing mutations help to understand the molecular basis of diseases. Although databases are available for protein-carbohydrate complexes based on structure, binding affinity and function, no specific database for mutations in human carbohydrate-binding proteins is reported in the literature. We have developed a novel database, CarbDisMut, a comprehensive integrated resource for disease-causing mutations with sequence and structural features. It has 1.17 million disease-associated mutations and 38,636 neutral mutations from 7,187 human carbohydrate-binding proteins. The database is freely available at https://web.iitm.ac.in/bioinfo2/carbdismut. The web-site is implemented using HTML, PHP and JavaScript and supports recent versions of all major browsers, such as Firefox, Chrome and Opera.
Discovering What Is Already Known: The Afro-Colombian Ancestral Justice System before the Special Jurisdiction for Peace
Authors: Bries Silva Nina 
Published: February 2024

ABSTRACT∞
For decades, Afro-Colombians have been ignored by Colombian society and its legal system. While the Colombian Constitution recognized the indigenous special jurisdiction, Afro-Colombian ancestral and traditional systems of justice were never acknowledged. The latter were further weakened by the armed internal conflict the country endured for more than half a century. In 2016, the Final Peace Agreement was signed and Colombia undertook its transitional justice process. This led for the first time to the recognition of the Afro-Colombian justice system as part of a transitional justice process. In conversation with an Afro-Colombian community leader of the Association of Community Councils of Norte Del Cauca, this article discusses the innovative interjurisdictional and intercultural mechanisms that have been designed by the Special Jurisdiction for Peace to interact with Afro-Colombians. It explores the implications of these legal developments for transitional justice in Colombia and beyond.
Health system performance assessment: embedding resilience through performance intelligence
Authors: Kringos Dionne , Ivanković Damir , Barbazza Erica , Klazinga Niek , Brito Fernandes Óscar 
Published: February 2024

Abstract
Health systems around the world are facing challenges in achieving their goals. In the wake of the coronavirus disease pandemic, the need for resilient health systems has become even more apparent. This article argues that embedding resilience into health system performance assessment (HSPA) frameworks can be a valuable approach for improving health system performance. This perspective examines key challenges threatening health systems and makes a case for the continued relevance of HSPA by embedding resilience-related performance intelligence.
Diagnosis-linked antibiotic prescribing quality indicators: demonstrating feasibility using practice-based routine primary care data, reliability, validity and their potential in antimicrobial stewardship
Authors: van den Eijnde Sharon E J D , van der Linden Paul D , van der Velden Alike W 
Published: February 2024

Abstract

Background
Quality indicators (QIs) can be used to obtain valuable insights into prescribing quality. Five quantitative and nine diagnosis-linked QIs, aiming to provide general practitioners (GP) with feedback on their antibiotic prescribing quantity and quality, were previously developed and evaluated in a controlled study.

Objective
To confirm, in a larger non-controlled study, the feasibility of using routinely collected and extracted electronic patient records to calculate the diagnosis-linked QI outcomes for antibiotic prescribing, and their reliability and validity.

Methods
Retrospective study involving 299 Dutch general practices using routine care data (2018–2020). QIs describe total antibiotic and subgroup prescribing, prescribing percentages and first-choice prescribing for several clinical diagnoses. Practice variation in QI outcomes, inter-QI outcome correlations and sensitivity of QI outcomes to pandemic-induced change were determined.

Results
QI outcomes were successfully obtained for 278/299 practices. With respect to reliability, outcomes for 2018 and 2019 were comparable, between-practice variation in outcomes was similar to the controlled pilot, and inter-QI outcome correlations were as expected, for example: high prescribing of second choice antibiotics with low first-choice prescribing for clinical diagnoses. Validity was confirmed by their sensitivity to pandemic-induced change: total antibiotic prescribing decreased from 282 prescriptions/1000 registered patients in 2018 to 216 in 2020, with a decrease in prescribing percentages for upper and lower respiratory infections, from 26% to 18.5%, and from 28% to 16%.

Conclusions
This study confirmed the fit-for-purpose (feasibility, reliability and validity) of the antibiotic prescribing QIs (including clinical diagnosis-linked ones) using routinely registered primary health care data as a source. This feedback can therefore be used in antibiotic stewardship programmes to improve GPs’ prescribing routines.
Evaluation of temocillin efficacy against KPC-2-producing Klebsiella pneumoniae isolates in a hollow-fibre infection model
Authors: Rodríguez-Ochoa José Luis , Pérez-Palacios Patricia , Merino-Bohórquez Vicente , Ortiz-Padilla Miriam , Velázquez-Escudero Ana , Rodríguez-Baño Jesús , Rodríguez-Martínez José Manuel , Pascual Álvaro , Docobo-Pérez Fernando 
Published: February 2024

Abstract

Background
Temocillin is an old antimicrobial that is resistant to hydrolysis by ESBLs but has variable activity against carbapenemase-producing Enterobacteriaceae. The current EUCAST susceptibility breakpoints for Enterobacterales are set at ≤16 mg/L (susceptible with increased exposure) based on a dose of 2 g q8h, but there is limited information on the efficacy of this dose against temocillin-susceptible carbapenemase-producing Klebsiella pneumoniae isolates.

Objectives
To evaluate the efficacy of this dose using a hollow-fibre infection model (HFIM) against six KPC-2-producing clinical isolates of K. pneumoniae.

Methods
The isolates were characterized by WGS and temocillin susceptibility was determined using standard and high inoculum temocillin. Mutant frequencies were estimated and temocillin activity was tested in time–kill assays and in the HFIM. At standard conditions, three of the isolates were classified as susceptible (MIC ≤ 16 mg/L) and three as resistant (MIC &gt; 16 mg/L). The HFIM was performed over 3 days to mimic human-like pharmacokinetics of 2 g q8h. Bacterial counts were performed by plating on Mueller–Hinton agar (MHA) and MHA containing 64 mg/L temocillin to detect resistant subpopulations.

Results
All isolates showed a reduction in bacterial population of at least 3 log cfu/mL within the first 8 h of simulated treatment in the hollow-fibre assay. Regrowth was observed for the three resistant isolates and one of the susceptible ones. The MIC value for these isolates was higher by at least two dilutions compared with their initial values.

Conclusions
These data suggest that an optimized pharmacokinetic regimen may be of clinical interest for the treatment of KPC-2-producing K. pneumoniae susceptible to temocillin. These data showed activity of temocillin against KPC-2-producing K. pneumoniae susceptible to temocillin; however, a dose of 2g q8h administered over 30 min may be inadequate to prevent the emergence of resistant variants.
Differential in vitro susceptibility to ampicillin/ceftriaxone combination therapy among Enterococcus faecalis infective endocarditis clinical isolates
Authors: Westbrook Kevin J , Chilambi Gayatri Shankar , Stellfox Madison E , Nordstrom Hayley R , Li Yanhong , Iovleva Alina , Shah Niyati H , Jones Chelsea E , Kline Ellen G , Squires Kevin M , Miller William R , Tran Truc T , Arias Cesar A , Doi Yohei , Shields Ryan K , Van Tyne Daria 
Published: February 2024

Abstract

Objectives
To investigate the genomic diversity and β-lactam susceptibilities of Enterococcus faecalis collected from patients with infective endocarditis (IE).

Methods
We collected 60 contemporary E. faecalis isolates from definite or probable IE cases identified between 2018 and 2021 at the University of Pittsburgh Medical Center. We used whole-genome sequencing to study bacterial genomic diversity and employed antibiotic checkerboard assays and a one-compartment pharmacokinetic–pharmacodynamic (PK/PD) model to investigate bacterial susceptibility to ampicillin and ceftriaxone both alone and in combination.

Results
Genetically diverse E. faecalis were collected, however, isolates belonging to two STs, ST6 and ST179, were collected from 21/60 (35%) IE patients. All ST6 isolates encoded a previously described mutation upstream of penicillin-binding protein 4 (pbp4) that is associated with pbp4 overexpression. ST6 isolates had higher ceftriaxone MICs and higher fractional inhibitory concentration index values for ampicillin and ceftriaxone (AC) compared to other isolates, suggesting diminished in vitro AC synergy against this lineage. Introduction of the pbp4 upstream mutation found among ST6 isolates caused increased ceftriaxone resistance in a laboratory E. faecalis isolate. PK/PD testing showed that a representative ST6 isolate exhibited attenuated efficacy of AC combination therapy at humanized antibiotic exposures.

Conclusions
We find evidence for diminished in vitro AC activity among a subset of E. faecalis IE isolates with increased pbp4 expression. These findings suggest that alternate antibiotic combinations against diverse contemporary E. faecalis IE isolates should be evaluated.
Detection of antimicrobial resistance in &lt;5 h in Neisseria gonorrhoeae isolates using flow cytometry—proof of concept for seven clinically relevant antimicrobials
Authors: Somajo Sofia , Nilsson Frida , Ekelund Oskar , Unemo Magnus 
Published: February 2024

Abstract

Introduction
Antimicrobial resistance in Neisseria gonorrhoeae compromises gonorrhoea treatment and rapid antimicrobial susceptibility testing (AST) would be valuable. We have developed a rapid and accurate flow cytometry method (FCM) for AST of gonococci.

Methods
The 2016 WHO gonococcal reference strains, and WHO Q, R and S (n = 17) were tested against seven clinically relevant antibiotics (ceftriaxone, cefixime, azithromycin, spectinomycin, ciprofloxacin, tetracycline and gentamicin). After 4.5 h incubation of inoculated broth, the fluorescent dye Syto™ 9 was added, followed by FCM analysis. After gating, the relative remaining population of gonococci, compared with unexposed growth control samples, was plotted against antimicrobial concentration, followed by non-linear curve regression analysis. Furthermore, the response at one single concentration/tested antibiotic was evaluated with the intention to use as a screening test for detection of resistant gonococci.

Results
A dose-dependent response was seen in susceptible isolates for all tested antimicrobials. There was a clear separation between susceptible/WT and resistant/non-WT isolates for ceftriaxone, cefixime, spectinomycin, ciprofloxacin and tetracycline. In contrast, for azithromycin, only high-level-resistant isolates were distinguished, while resistant isolates with MICs of 4 mg/L were indistinguishable from WT (MIC ≤ 1 mg/L) isolates. For gentamicin, all tested 17 isolates were WT and FCM analysis resulted in uniform dose–response curves. Using a single antibiotic concentration and a 50% remaining cell population cut-off, the overall sensitivity and specificity for resistance detection were 93% and 99%, respectively.

Conclusions
By providing results in &lt;5 h for gonococcal isolates, FCM-based AST can become a rapid screening method for antimicrobial resistance or antimicrobial susceptibility in gonococci.
Experiences of an inpatient penicillin allergy de-labelling pathway: capturing the patient voice
Authors: Powell Neil , Upton Mathew , Kent Bridie , Sandoe Jonathan , Tonkin-Crine Sarah 
Published: February 2024

Abstract

Background
Non-allergist-delivered penicillin allergy de-labelling (PADL) is supported by UK and other national guidelines but is not yet routine practice in UK hospitals. Those who have undergone PADL report high rates of acceptance, but it is unknown why some continue to avoid penicillin, and why some decline testing.

Objectives
To explore the experiences of patients recently approached for penicillin allergy (penA) assessment and de-label by non-allergists in a UK hospital to determine the barriers and enablers to patient acceptance of PADL.

Methods
Qualitative study using semi-structured interviews with patients who were penA assessed and de-labelled during an inpatient stay between November 2022 and January 2023. Thematic analysis was used to analyse the data.

Results
Nineteen patients were interviewed. Patients were largely unaware of the negative impact of penA on their healthcare. Patients had differing views on challenging their penA status while they were acutely unwell, some agreeing that it is the right time to test and others not. Patients declined testing because they felt they were at higher potential risk because they were older or had multiple comorbidities. Some patients who declined testing felt they would have been persuaded if they had received a better explanation of the risks and benefits of PADL.

Conclusions
Patients who were successfully de-labelled were positive about the experience. Those who declined testing did so for a variety of reasons including frailty/comorbidities or a fear of testing whilst unwell. Patients highlighted the importance of good communication about the personalized risks and benefits of testing.
Laboratory domestication of Lactiplantibacillus plantarum alters some phenotypic traits but causes non-novel genomic impact
Authors: Surve Sarvesh V , Shinde Dasharath B , Fernandes Joyleen M , Sharma Sharoni , Vijayvargiya Monty , Kadam Komal , Kulkarni Ram 
Published: February 2024

Abstract

Aims
Laboratory domestication has been negligibly examined in lactic acid bacteria (LAB). Lactiplantibacillus plantarum is a highly studied and industrially relevant LAB. Here, we passaged L. plantarum JGR2 in a complex medium to study the effects of domestication on the phenotypic properties and the acquisition of mutations.

Methods and results
Lactiplantibacillus plantarum JGR2 was passaged in mMRS medium (deMan Rogossa Sharpe supplemented with 0.05% w/v L-cysteine) in three parallel populations for 70 days. One pure culture from each population was studied for various phenotypic properties and genomic alterations. Auto-aggregation of the evolved strains was significantly reduced, and lactic acid production and ethanol tolerance were increased. Other probiotic properties and antibiotic sensitivity were not altered. Conserved synonymous and non-synonymous mutations were observed in mobile element proteins (transposases), β-galactosidase, and phosphoketolases in all three isolates. The evolved strains lost all the repeat regions and some of the functions associated with them. Most of the conserved mutations were found in the genomes of other wild-type strains available in a public database, indicating the non-novel genomic impact of laboratory passaging.

Conclusions
Laboratory domestication can affect the phenotypic and genotypic traits of L. plantarum and similar studies are necessary for other important species of LAB.
Bridging information gaps in menopause status classification through natural language processing
Authors: Eyre Hannah , Alba Patrick R , Gibson Carolyn J , Gatsby Elise , Lynch Kristine E , Patterson Olga V , DuVall Scott L 
Published: February 2024

Abstract

Objective
To use natural language processing (NLP) of clinical notes to augment existing structured electronic health record (EHR) data for classification of a patient’s menopausal status.

Materials and methods
A rule-based NLP system was designed to capture evidence of a patient’s menopause status including dates of a patient’s last menstrual period, reproductive surgeries, and postmenopause diagnosis as well as their use of birth control and menstrual interruptions. NLP-derived output was used in combination with structured EHR data to classify a patient’s menopausal status. NLP processing and patient classification were performed on a cohort of 307 512 female Veterans receiving healthcare at the US Department of Veterans Affairs (VA).

Results
NLP was validated at 99.6% precision. Including the NLP-derived data into a menopause phenotype increased the number of patients with data relevant to their menopausal status by 118%. Using structured codes alone, 81 173 (27.0%) are able to be classified as postmenopausal or premenopausal. However, with the inclusion of NLP, this number increased 167 804 (54.6%) patients. The premenopausal category grew by 532.7% with the inclusion of NLP data.

Discussion
By employing NLP, it became possible to identify documented data elements that predate VA care, originate outside VA networks, or have no corresponding structured field in the VA EHR that would be otherwise inaccessible for further analysis.

Conclusion
NLP can be used to identify concepts relevant to a patient’s menopausal status in clinical notes. Adding NLP-derived data to an algorithm classifying a patient’s menopausal status significantly increases the number of patients classified using EHR data, ultimately enabling more detailed assessments of the impact of menopause on health outcomes.
Physiological impacts of climate change on juvenile American lobster Homarus americanus (Decapoda: Astacidea: Nephropidae), a commercially important species
Authors: San Antonio Christine , Tlusty Michael , Hannigan Robyn 
Published: February 2024

Abstract
The American lobster, Homarus americanus, H. Milne Edwards, 1837 is an ecologically, economically, and culturally valuable marine resource for the coastal communities in the Gulf of Maine. Lobsters in the Gulf of Maine are experiencing the effects of rapid warming and acidification due to climate change. Lobster shells are comprised of chitin with precisely precipitated minerals (calcite, amorphous calcium carbonate, and carbonate apatite) that provide structural integrity to the shell and protection against predators and microbial intrusion. We examined the combined effects of ocean warming and acidification on shell mineralogy, epibiont abundance, and growth in early benthic juveniles. Lobsters were grown under six different temperature/pCO2 treatment conditions over 52 days (three replicates per treatment) aligned with environmentally relevant as well as predicted future extremes. Elevated pCO2 and temperature led to a decrease in shell calcium and magnesium content, suggesting that these environmental stressors inhibit shell biomineralization. There was an interactive effect of the stressors on epibiont abundance with the probability of epibiont coverage increasing with increasing pCO2 and temperature. Elevated pCO2 alone was significantly correlated (P = 0.002) to decreased growth, but only for female lobsters. Ocean acidification and warming significantly affect shell integrity in juvenile lobster, increasing risk to injury and disease with potential downstream consequences for the lobster fishery.
Social network analysis and counterterrorism: a double-edged sword for international humanitarian law
Authors: Moncrieff Michael , Kilibarda Pavle , Gaggioli Gloria 
Published: February 2024

Abstract
The use of social network analysis (SNA) during the War on Terror has been a topic of significant political and academic discourse. SNA is an empirical method that graphically and mathematically represents interactions or relationships between nodes (eg, individuals, organizations) and the ties that connect them. The nature and degree of interdependence among nodes are believed to provide insights into the relationships and behaviour of members within a social network. The scarcity of precise and comprehensive data on the structure, functioning, and activities of terrorist groups has prompted some states to incorporate SNA into their intelligence efforts and rely on its data for counterterrorism activities, including lethal operations. However, the compatibility of SNA with international law remains underexplored. In this article, we adopt a legal-empirical approach to elucidate SNA in accessible terms and examine the challenges it presents for international law. We contend that SNA is fundamentally incompatible with international humanitarian law (IHL) targeting rules, as the data it provides do not pertain to legally relevant criteria. Nevertheless, SNA offers valuable insights for IHL by illuminating intra-group dynamics to facilitate conflict classification, identifying legally relevant characteristics in armed groups’ internal networks, and determining the strength of relations between armed factions. Our findings underscore the importance of a nuanced understanding of SNA’s applications and limitations in the context of international law.