bluuebunny/crossref_metadata_2025_split huggingface dataset:
A congenital renal anomaly concomitant with a vascular emergency: a case of an ectopic pelvic kidney accompanied by aortoiliac aneurysms
Authors: Aljadaan Mudar , Al Laham Omar , Khaled Louay , Eljerdie Joudy , Ghannam Mohammad , Mohammad Ammar 
Published: February 2024

Introduction and importance:
Ectopic pelvic kidneys are an extremely rare congenital renal system anomaly. This embryological occurrence transpires between the 4th and 8th gestational weeks, and is seen in 1 in every 2100–3000 births. Moreover, research articles indicate an incidence of ectopic pelvic kidneys ranging from 0.033 to 0.047%. The co-occurrence of this anomaly with an abdominal aortic aneurysm is an even rarer finding.

Case presentation:
We report a rare case involving a 62-year-old Middle Eastern male with a right ectopic pelvic kidney. The condition initially manifested as vague abdominal discomfort in the periumbilical region. The pain evolved into a continuous, localized, and insidious sensation. This was escorted by the perception of a pulsatile abdominal mass. Preoperative radiology illustrated a right ectopic pelvic kidney with concomitant aortoiliac aneurysms.

Clinical discussion:
Via a successful surgical intervention, the abdominal aortic aneurysms were repaired via synthetic Dacron grafts and the renal perfusion to the ectopic pelvic kidney was secured. Moreover, the aneurysmal wall underwent a full histopathological analysis, and the results of which indicated an atherosclerotic cause.

Conclusion:
Ectopic pelvic kidneys are an exceptionally rare congenital anomaly, especially when coupled with life-threatening co-occurrences like an abdominal aortic aneurysm. The need for timely surgical interventions is critical, and this topic requires comprehensive documentation as a guide for surgical professionals. This unique case is the first documented instance in the country. It emphasizes the fundamental role of proper intraoperative techniques in repairing aneurysmal conditions while preserving the function of the ectopic kidney.
Impact of Acute Exacerbation of Idiopathic Pulmonary Fibrosis on Lung Transplant Outcomes
Authors: Warrior Krishnan , Sayad Karen , O’Hara Christopher P. , Dilling Daniel F. 
Published: January 2024

Background.
Acute exacerbations of idiopathic pulmonary fibrosis (AE-IPF) are acute, significant respiratory deteriorations in patients with IPF and can lead to increased morbidity and mortality. It remains unclear how AE-IPF impacts lung transplant (LTX) outcomes.

Methods.
All adult patients who were listed for LTX between July 2005 and October 2020 at the Loyola University Medical Center with a diagnosis of IPF were included. Pretransplant characteristics and posttransplant outcomes were gathered via retrospective chart review. The primary outcome was short- and long-term survival for patients transplanted during stable IPF versus those with AE-IPF.

Results.
One hundred fifty-nine patients were included in this study, 17.6% of whom were transplanted during AE-IPF. AE-IPF patients were more likely to have higher oxygen needs pretransplant, have higher lung allocation score, and were more likely to be intubated or be on extracorporeal membrane oxygenation as compared with stable IPF patients. Survival by AE status at transplant did not differ at 90 d or 1 y posttransplantation. There were also no significant differences in rates of severe primary graft dysfunction or acute rejection within 1 y.

Conclusions.
Patients with AE-IPF were more likely to have higher oxygenation requirements and higher lung allocation score at the time of LTX than those with stable IPF. Despite this, there were no differences in survival at 90 d, 1 y, or 3 y, or differences in incidence of severe primary graft dysfunction or acute cellular rejection. Transplantation of patients with AE-IPF has clinical outcomes comparable with transplantation of patients with stable IPF. This contrasts with previous studies examining LTX in patients with AE-IPF.
Posttraumatic headache is a distinct headache type from migraine
Authors: Ihara Keiko , Schwedt Todd J. 
Published: January 2024

Purpose of review
Posttraumatic headache (PTH), a headache that develops within 7 days of a causative injury, is one of the most common secondary headaches, mostly attributed to mild traumatic brain injury (mTBI). Because presence of preinjury headache is a risk factor for developing PTH and PTH symptoms often resemble migraine or tension-type headache, the association between PTH and primary headaches has attracted attention from clinicians and scientists.

Recent findings
Recent studies on epidemiological aspects, headache features, risk factors, imaging characteristics, and response to treatment, suggest overlapping features and distinct objective findings in PTH compared to migraine.

Summary
We argue that PTH is distinct from migraine. Therefore, PTH epidemiology, pathophysiology, diagnosis, treatment, and prognosis should continue to be investigated separately from migraine.
Intraoperative Neurophysiologic Monitoring and Mapping in Children Undergoing Brainstem Surgery
Authors: Deletis Vedran , Seidel Kathleen , Fernández-Conejero Isabel 
Published: February 2024

Summary:
Intraoperative neurophysiologic monitoring during surgery for brainstem lesions is a challenge for intraoperative neurophysiologists and surgeons. The brainstem is a small structure packed with vital neuroanatomic networks of long and short pathways passing through the brainstem or originating from it. Many central pattern generators exist within the brainstem for breathing, swallowing, chewing, cardiovascular regulation, and eye movement. During surgery around the brainstem, these generators need to be preserved to maintain their function postoperatively. This short review presents neurophysiologic and neurosurgical experiences of brainstem surgery in children.
Identification of causative fungus from sterilized or bacteriostatic abscess using metagenomics followed by in situ hybridization
Authors: Oki Hiroya , Niwa Ryotaro , Pranee Somboonthum , Motooka Daisuke , Onda Yoshiyuki , Nakata Jun , Nakajima Hiroko , Oka Yoshihiro , Sugiyama Haruo , Yoshii Yuka , Anzai Naoyuki , Nakamura Shota , Iida Tetsuya 
Published: February 2024

Introduction: Invasive fungal infections require early diagnosis for treatment. Microscopic observation of biopsy and blood culture are the gold standard for identification of the causative fungus, but it is difficult to identify the causative pathogen by a sterile or static abscess biopsy.
Case Presentation: We present a case report of breakthrough invasive trichosporonosis in a 65-year-old Japanese male with acute myeloid leukemia (AML) receiving antifungal prophylaxis. Blood cultures showed no fungal growth, and a liver biopsy and a removed spleen with abscess showed fragmented fungi, but no fungal identification was possible. This report demonstrates that retrospective analyses were able to identify the causative fungus.
Conclusion: We narrowed down the candidate fungi by deep sequencing of the ITS1 region of fungal genome and confirmed that the fungus observed in the specimen was T. asahii by in situ hybridization using a DNA probe targeting 26S rRNA.
Blood flow occlusion superimposed on submaximal knee extensions does not evoke hypoalgesia: A pilot study
Authors: Morgan Sophie-Jayne , Lemay Neil , Zhang Jenny , Khaledi Neda , Aboodarda Saied Jalal 
Published: January 2024

ABSTRACTExercise-induced hypoalgesia (EIH) is a transient decrease in pain perception that can be observed following various tasks, including non-painful low-intensity and painful high-intensity exercise. The application of blood flow occlusion (BFO) can help enhance exercise adaptations while being able to exercise at a low intensity, which has important implications for clinical and rehabilitative settings. Through descending inhibitory pathways, BFO-induced pain can potentially alleviate exercise-induced pain. This study aimed to assess whether the superimposition of BFO – and its associated augmented perceived responses – during low-intensity, low-volume resistance exercise could induce hypoalgesia. Nineteen healthy adults (10 females) attended three sessions: i) no exercise (CTRL), ii) two minutes of dynamic single-leg knee extension at 10% body weight (EXER), and iii) EXER with complete occlusion applied to the upper exercising leg (OCCL). Handheld algometry-derived pain pressure threshold (PPT) of the trapezius and contralateral and ipsilateral rectus femoris muscles were measured pre- and post-exercise, and after 5 and 10 min of recovery. Perceived pain (0-10) and effort (6-20) were also rated after exercise. Although pain and effort were augmented in the OCCL condition (Pain: 6±2; Effort: 14±3) compared to CTRL (Pain: 2±2,p<0.001; Effort 9±2,p=0.017), PPT of all muscles did not change across time nor between any conditions. Therefore, the low-intensity, low-volume resistance exercise prescribed in the present study was insufficient to evoke EIH even with the application of BFO-induced pain.
Both the transcriptional activator, Bcd, and transcriptional repressor, Cic, form small mobile oligomeric clusters in early fly embryo nuclei
Authors: Zhang Lili , Hodgins Lydia , Sakib Shariful , Mahmood Ahmad , Perez-Romero Carmina , Marmion Robert A. , Dostatni Nathalie , Fradin Cécile 
Published: February 2024

ABSTRACTTranscription factors play an essential role in pattern formation during early embryo development, generating a strikingly fast and precise transcriptional response that results in sharp gene expression boundaries. To characterize the steps leading up to transcription, we performed a side-by-side comparison of the nuclear dynamics of two morphogens, a transcriptional activator, Bicoid (Bcd), and a transcriptional repressor, Capicua (Cic), both involved in body patterning along the anterior-posterior axis of the earlyDrosophilaembryo. We used a combination of fluorescence recovery after photobleaching, fluorescence correlation spectroscopy, and single particle tracking to access a wide range of dynamical timescales. Despite their opposite effects on gene transcription, we find that Bcd and Cic have very similar nuclear dynamics, characterized by the co-existence of a freely diffusing monomer population with a number of oligomeric clusters, which range from low stoichiometry and high mobility clusters to larger, DNA-bound hubs. Our observations are consistent with the inclusion of both Bcd and Cic into transcriptional hubs or condensates, while putting constraints on the mechanism by which these form. These results fit in with the recent proposal that many transcription factors might share a common search strategy for target genes regulatory regions that makes use of their large unstructured regions, and may eventually help explain how the transcriptional response they elicit can be at the same time so fast and so precise.SIGNIFICANCEBy conducting a comparative study of the nuclear dynamics of Bicoid (a transcriptional activator) and Capicua (a transcriptional repressor) in theDrosophilaembryo, we have uncovered a striking similarity in their behaviours. Despite their divergent roles in transcription, both proteins have a propensity to form oligomeric species ranging from highly mobile, low stoichiometry clusters to larger, DNA-bound hubs. Such findings impose new constraints on the existing models of gene regulation by transcription factors, particularly in aspects related to target search and oligomeric binding to gene regulatory regions needed to explain the rapid and precise transcriptional response observed in developmental processes.
Formulation, Characterization and Pharmacokinetic Evaluation of Amorphous Solid Dispersions of Glibenclamide for Bioavailability Enhancement in Wistar Rats
Authors: Mir Khalid Bashir , Khan Nisar Ahmed , Shah Mehraj D. , Dar Alamgir A. 
Published: February 2024

AbstractOral bioavailability of Glibenclamide (Glb) was appreciably improved by forming amorphous solid dispersion (ASD) with Poloxamer-188 (P-188). Poloxamer-188 substantially enhanced the solubility and thereby dissolution rate of the BCS Class-II drug, Glibenclamide (Glb) and simultaneously exhibited better stabilizing effect of amorphous solid dispersion prepared by solvent evaporation method. The physical state of the dispersed Glibenclamide in the polymeric matrix was characterized by differential scanning calorimetry, X-ray diffraction, scanning electron microscope and Fourier Transform Infrared studies.In vitrodrug release in buffer (pH 7.2) revealed that amorphous solid dispersion at the Glb-P-188 ratio of 1:6 (SDE4) improved the dissolution of Glibenclamide 90% within 3 hrs. Pharmacokinetic study of the solid dispersion formulation (SDE4) formulation in wistar rats showed that oral bioavailability of the drug was greatly increased as compared to market tablet formulation, Daonil®. Solid dispersion formulation (SDE4) resulted in approximately two fold higher AUC0-24hrs. Solid dispersion formulation (SDE4) formulation was found stable during the study period of six months.
DoliClock: A Lipid-Based Aging Clock Reveals Accelerated Aging in Neurological Disorders
Authors: Latumalea Djakim , Unfried Maximilian , Barardo Diogo , Gruber Jan , Kennedy Brian K. 
Published: February 2024

AbstractAging is a multifaceted process influenced by intrinsic and extrinsic factors, with lipid alterations playing a critical role in brain aging and neurological disorders. This study introduces DoliClock, a lipid-based biological aging clock designed to predict the age of the prefrontal cortex using post-mortem lipidomic data. Significant age acceleration was observed in samples with autism, schizophrenia, and Down syndrome, with autism showing the most pronounced effects in aging-rate. An increase in entropy around age 40, suggests dysregulation of the mevalonate pathway and dolichol accumulation. Dolichol, a lipid integral to N-glycosylation and intracellular transport, emerged as a potential aging biomarker, with specific variants such as dolichol-19 and dolichol-20 showing unique age-related associations. These findings suggest that lipidomics can provide valuable insights into the molecular mechanisms of brain aging and neurological disorders. By linking dolichol levels and entropy changes to aging, this study highlights the potential of lipid-based biomarkers for understanding and predicting biological age, especially in conditions associated with premature aging.
Force-transducing molecular ensembles at growing microtubule tips control mitotic spindle size
Authors: Chu Lee-Ya , Stedman Daniel , Gannon Julian , Cox Susan , Pobegalov Georgii , Molodtsov Maxim 
Published: February 2024

AbstractMitotic spindle is a complex bipolar cellular structure that ensures chromosomes segregation between dividing cells. Correct spindle size is required for the accurate segregation and successful passing of genomes to the newly formed cells. The spindle size is believed to be controlled by mechanical forces generated by molecular motors and non-motor proteins acting in the spindle microtubule overlaps. However, how forces generated by individual proteins enable bipolar spindle organization is not well understood. Here, we developed tools to measure contributions of individual molecules to this force balance. We show that microtubule tip-trackers act synergetically at microtubule tips with minus-end directed motors to produce a system that can generate both pushing and pulling forces. We show that this system harnesses forces generated by growing tips of spindle microtubules and provides unique contribution to the force balance distinct from other force generators because it acts at microtubule tips rather than in microtubule overlaps. We show that this system alone can establish stable bipolar organization in vitro and in mitotic spindles in human cells. Our results pave the way for understanding how mechanical forces in spindles can be fine-tuned to control the fidelity of chromosome segregation.
The bright side of post-pandemic remote working: examining the effect of self-efficacy and work-related flow on employee resilience
Authors: Dogra Prinka , Parrey Aubid Hussain , Bhawna Bhawna , Akram Umair 
Published: February 2024

Purpose
This study aims to integrate the social cognitive theory and flow theory to examine how e-skills self-efficacy (ESSE) and trust-building self-efficacy (TBSE) impact work-related flow in remote work. It also explores how work-related flow (WOLF) mediates the connection between these factors and employee resilience (ER) in the context of the growing shift toward remote work.

Design/methodology/approach
The study tested an empirical mediation model with 535 remote workers from Indian organizations that adopted remote work either before or during the pandemic. Hypotheses were tested using Hayes’ PROCESS macro.

Findings
The study confirmed the direct influence of ESSE and TBSE on WOLF. Moreover, a mediation analysis demonstrated that WOLF significantly mediates the association linking ESSE, TBSE and ER.

Practical implications
This study, evaluating experienced remote employees in the quaternary sector, offers data-driven insights for informed organizational decisions. These findings aims to guide HR and training departments in formulating recruitment and training strategies, emphasizing digital skill development to enhance knowledge and skills effectively.

Originality/value
This study highlights the need for remote workers and organizations to be aware of the challenges of remote work. It is among the first to explore the link between ESSE, TBSE and ER, addressing psychological factor, i.e. WOLF, often overlooked in organizational contexts.
The information-seeking behaviors of project managers in professional virtual communities
Authors: Kenworthy Thomas P. 
Published: February 2024

Purpose This research explores project manager (PM) behavior in their professional virtual communities (PVCs), using social identity theory as a theoretical foundation. The purpose is to examine the extent to which PMs seek information on key topics in the Project Management Body of Knowledge Guide (PMBoK).Design/methodology/approach A text data analytics methodology that uses quantitative and qualitative analysis techniques is followed. The research method reveals relationships in language-based data gathered from six project management forums and blogs.Findings Information related to all the PMBoK topics is sought in the project management virtual communities. People management topics account for a dominant portion of interactions. The findings enhance social identification theorizing for the PM role. From a practical standpoint, the findings shed light on focal areas for greater emphasis in PM PVCs.Originality/value Our people management finding constructively replicates existing findings via a large, global sample and strengthens calls for increased focus on people management matters in project management. As a result, we call for increased scholarly attention to people management in project management. Finally, we encourage pursuit of several research questions to enhance knowledge of PM information-seeking behavior.
Bridging the trust gap in financial reporting: the impact of blockchain technology and smart contracts
Authors: Rawashdeh Awni 
Published: February 2024

Purpose
This study aims to examine the role of blockchain technology (BCT) in trust in financial reporting (TFR) and the use of smart contracts (USC). It aims to ascertain the mediating role of USC in the relationship between BCT and TFR, thereby contributing to the limited empirical literature in this domain.

Design/methodology/approach
Based on a sample of the accountants’ familiarity with BCT, a structural equation model was constructed and analyzed using AMOS 24. The model proposes and tests relationships between BCT, USC and TFR.

Findings
The study highlights BCT’s significant positive influence on TFR, with USC mediating this effect. It provides empirical evidence that supports the transformative potential of BCT and USC in enhancing TFR.

Practical implications
These findings have significant implications for practitioners, regulatory bodies and policymakers. By highlighting the effectiveness of BCT and USC in fostering TFR, the study makes one aware of strategies to mitigate financial malpractices. It promotes the adoption of BCT in accounting practices.

Originality/value
This study addresses a gap in the literature by investigating the complex interplay of BCT, USC and TFR. It offers a unique perspective by exploring the mediating role of USC, thereby enhancing our understanding of the mechanisms through which BCT can foster TFR.
What determines the adoption of Islamic finance products in a non-Islamic country? Empirical evidence from Cameroonian small- and medium-sized enterprises
Authors: Haruna Ali , Oumbé Honoré Tekam , Kountchou Armand Mboutchouang 
Published: February 2024

Purpose
The purpose of this paper is to examine the adoption of Islamic finance products (murabaha, musharakah, mudarabah, salam, ijara, istisna and Qard Hassan) by small and medium-sized enterprises (SMEs) in Cameroon, a non-Islamic Sub-Saharan African country.

Design/methodology/approach
It used primary data collected from a cross-section of 1,358 SMEs in eight regions of Cameroon using self-administered structured questionnaires. To facilitate the analyses and interpretation, these products are grouped into four groups based on certain characteristics. A multivariate probit model is estimated to take into account the interaction between these different Islamic finance products.

Findings
This study revealed that the desire to comply with Sharia law, awareness, attitude and intention were critical determinants of the decision to adopt Islamic finance products by Cameroonian SMEs. The least influential factors were perceived behavioral control, subjective norms, enterprise characteristics (size, age and location) and socio-demographic characteristics of the entrepreneur (gender, age and marital status). The extension of the multivariate approach permitted us to compute for predicted probabilities which revealed that there exists a synergy effect between the different Islamic finance products. That is, Cameroonian SMEs combine different Islamic finance products at the same time based on their needs. This is especially the case between the partnership-based products (musharakah and mudarabah) and manufacture/rent products (istisna and ijara).

Practical implications
Policymakers are encouraged to develop stakeholder-oriented strategies to promote effective consumer education in Islamic finance products which will boost awareness. Also, Islamic finance institutions should endeavor to develop innovative financial products that are Sharia-compliant and economically beneficial to the individual and business needs of SMEs. Moreover, policymakers and management of Islamic finance institutions should ensure the putting in place of effective governance structures to guide Islamic finance operations. Finally, policymakers should endeavor to take into account the possible synergy between the different Islamic finance products in their quest to develop this activity.

Originality/value
To the best of the authors’ knowledge, this is the first study that analyses the adoption of different Islamic finance products while taking into account the possible synergy that exists between these products.