bluuebunny/crossref_metadata_2025_split huggingface dataset:
Interferon system in typical chronic and atypically occurring chronic active herpes virus infections
Authors: Khalturina E. O. , Nesterova I. V. , Malinovskaya V. V. , Myandiev M. S. 
Published: December 2023

Objective: to study the characteristics of the functioning of the IFN system, the presence of autoantibodies to INFα in patients suffering from atypical chronic active herpesvirus infections (ACA-HVI) in comparison with patients with a typical course of chronic herpesvirus infections (CHVI).Materials and methods: under our supervision were 485 patients of both sexes aged 23 to 70 years, suffering from chronic herpes virus infections, of which 335 patients suffered from AHA-HVI and 150 people suffered from CHVI. The comparison group was 250 conditionally healthy individuals (CG). The complex of the study included methods for detecting herpesviruses: serodiagnostics, PCR-RT. The IFN system (spontaneous and induced production, serum concentration) was tested by ELISA. The study was approved by the ethics board and informed consent was obtained from all patients.Results: the incidence of various mono-mixed herpesvirus infections in patients with ACA-HVI (mono – 26,6% and mixed – 73.4%) and CHVI (mono – 23.1% and mixed – 76.9%) was determined, with EBV dominance in patients of both groups. Serum IFNα deficiency was detected in 100% of cases in both groups, and IFNα in 67% in ACA-HVI and 57% in CHVI. At the same time, significant differences were found between the ACA-HVI and HGVI groups in the level of IFNα reduction: 10 and 5 times, respectively, and for IFNγ – 2.0 and 2.6 times, respectively. The induced IFNα production decreased by 89.1% in ACA-HVI and 47.2% in CHVI. A decrease in induced IFNγ production is characteristic of 50% of patients in both groups. At the same time, the level of induced production of IFN α in patients with ACA-HVI was 9 times lower than in the control group and 4.75 times lower than in the group of patients with CHVI. And the level of induced IFNγ production was 2 times lower compared to CHVI and the control group.Conclusions: when assessing the state of the IFN system in patients with various chronic herpes virus infections, significant differences were revealed. Thus, the most pronounced manifestations of interferonopathy, consisting in a significant decrease in serum IFNα and IFNγ and defects in induced IFN production of both types, are observed statistically significantly more often in the group of patients with an atypical course of the disease than in the group of patients with a typical course of CHVI. The most pronounced disorders in the IFN system and the lack of recovery of IFNα and IFNγ levels in the interrelational period cause atypicity of the course and active viral replication in patients with ACA-HVI.
Advances and Opportunities of Mobile Health in the Postpandemic Era: Smartphonization of Wearable Devices and Wearable Deviceization of Smartphones
Authors: Hong Wonki 
Published: December 2023

Abstract
Mobile health (mHealth) with continuous real-time monitoring is leading the era of digital medical convergence. Wearable devices and smartphones optimized as personalized health management platforms enable disease prediction, prevention, diagnosis, and even treatment. Ubiquitous and accessible medical services offered through mHealth strengthen universal health coverage to facilitate service use without discrimination. This viewpoint investigates the latest trends in mHealth technology, which are comprehensive in terms of form factors and detection targets according to body attachment location and type. Insights and breakthroughs from the perspective of mHealth sensing through a new form factor and sensor-integrated display overcome the problems of existing mHealth by proposing a solution of smartphonization of wearable devices and the wearable deviceization of smartphones. This approach maximizes the infinite potential of stagnant mHealth technology and will present a new milestone leading to the popularization of mHealth. In the postpandemic era, innovative mHealth solutions through the smartphonization of wearable devices and the wearable deviceization of smartphones could become the standard for a new paradigm in the field of digital medicine.
Сучасні підходи до комплексного лікування ожиріння з пацієнторієнтованим підходом
Authors: Tkachenko V.I. , Bagro T.O. 
Published: December 2023

Актуальність. Ожиріння зростає кожного року, погіршує прогноз щодо здоров'я населення, розвитку неінфекційних захворювань та їх ускладнень, інвалідізації та смертності, має негативні соціо-економічні наслідки. Серед ефективних методів лікування ожиріння відомі різні підходи дієтотерапії, психотерапевтичні методики, застосування деяких медикаментозних засобів і хірургічних втручань, але складний патогенез ожиріння зумовлює пошук доказової бази щодо більшого спектру терапевтичих підходів. Мета – провести системний аналіз літератури та проаналізувати сучасні підходи доказової медицини щодо комплексного лікування ожиріння з пацієнторієнтованим підходом. Матеріали та методи. Системний огляд літературних джерел у проблематиці ожиріння щодо його патогенетичних аспектів за ключовими словами: obesity, overveight, guidelines, standarts, protocols of care, treatment, evidence based medicine за період 2012 – 2023 рр. у базах даних PubMed та Cochrane. Для аналізу застосовували бібліосемантичний метод та метод системного аналізу. Результати. Для системного аналізу було відібрано 76 джерел літератури серед знайдених публікацій у PubMed та Cochrane, які найбільш відповідали ключовим словам та поставленій меті дослідження. Опрацьовано 15 міжнародних і національних керівництв щодо лікування ожиріння. Встановлено, що основними принципами лікування ожиріння є застосування пацієнт-орієнтованого комплексного підходу з тривалим наглядом та впровадженням необхідних змін до способу життя, дієтичних звичок, фізичної активності шляхом мотиваційного консультування в комбінації з медикантозними засобами для зменшення ваги на, близько, 5-10 % за 6 місяців. Серед засобів медикаментозного лікування найбільшу ефективність мають препарати центрального механізму дії: сибутрамін, ліраглутид, семаглутид, налтрексон/ бупропіон, фентермін, фентермін/топірамат, лоркасерин. Перспективним у лікуванні ожиріння в майбутньому може стати армодафініл, через його вплив на серотонінгергічну систему, особливо в комплексному пацієнторієнтованому лікуванні пацієнтів з ожирінням, які мають порушення сну і неспання. В Україні нині зареєстровані та рекомендовані для лікування ожиріння лише орлістат та ліраглутід. Висновки. Визначені на сьогодні етіо-патогенетичні механізми розвитку ожиріння свідчать про мультидисциплінарність даної проблеми і необхідність залучення команди спеціалістів для тривалого нагляду та підбору пацієнторієнтованого комплекного лікування.
Exploration of 4-Chloro-3-nitrocoumarin: Spectroscopic Analysis, DFT Insights, Molecular Docking, Assessments of Antibacterial and In Vitro Anticancer Activities as a Potent Bioactive Agent
Authors: Mohan Surya S. , Meera M.R. , Rathika A. , Premkumar R. 
Published: December 2023

The detailed theoretical and experimental (FT-IR, FT-Raman, UV-visible) spectroscopy analyses of the 4-Chloro-3-nitrocoumarin (CNC) molecule were carried out. The CNC compound's pharmacological properties were also investigated utilizing antibacterial and anticancer activity investigations. Initially, the CNC molecule was optimized by the density functional theory B3LYP method with a cc-pVTZ basis set using the Gaussian 09W program. The optimized molecular structure provides the harmonic vibrational frequencies of the CNC molecule. The observed and computed vibrational wavenumbers were assigned and found to be well correlated. UV-Vis absorption spectrum analysis indicates that the molecule contains π→π* electronic transition. Frontier molecular orbitals (FMOs) analysis indicates that the LUMO of CNC molecule is mainly located over the nitro group, it indicates that the nitro group is particularly prone to accepting electrons from other molecules and participate in chemical reactions where acts as an electrophile. Mulliken atomic charge distribution analysis further confirms the FMOs results. The antibacterial test results validate that the CNC molecule exhibits a stronger inhibitory effect on Staphylococcus aureus compared to the other tested bacteria. In vitro anticancer cytotoxicity analysis clearly evidences that the CNC compound inhibits the growth of HeLa cervical cancer cell lines more than A549 lung cancer cell lines. In silico molecular docking study further validates that the CNC molecule inhibits the function of the p38a Mitogen-activated protein kinase 14, which has been associated with cervical cancer. As a result, the present study paves the way for the development of new drugs to treat cervical cancer.
Keywords: 4-Chloro-3-nitrocoumarin; DFT; FT-IR; FT-Raman; Anticancer; Molecular docking; Cervical cancer drug.
Experiencias de profesores de enfermería durante la pandemia por COVID-19: una mirada desde el proceso de enseñanza-aprendizaje
Authors: Ochoa-Marin Sandra Catalina , Restrepo-Betancur Vanessa 
Published: December 2023

Objetivo Describir las experiencias de los profesores en el proceso de enseñanza-aprendizaje durante la pandemia en una facultad de enfermería en Medellín, Colombia. Materiales y métodos Estudio cualitativo para el cual se realizaron once entrevistas individuales semiestructuradas. Los participantes fueron profesores universitarios de una facultad de enfermería en Medellín, Colombia. El análisis se usando elementos de la teoría fundamentada; se realizó el análisis línea a línea, lo que permitió agrupar los datos en las siguientes categorías: transformación del proceso de enseñanza -aprendizaje; efectos del proceso de enseñanza - aprendizaje; redes de apoyo; lecciones aprendidas de la experiencia. Resultados La transformación del proceso de enseñanza - aprendizaje, el manejo de herramientas tecnológicas, los efectos del rápido cambio en las metodologías de enseñanza, y las redes de apoyo de los docentes universitarios fueron las temáticas principales que surgieron de los participantes en cuanto a su experiencia en la educación de enfermería. Conclusión La educación de enfermería durante la pandemia en Colombia requirió de grandes esfuerzos de los profesores para continuar con el proceso de enseñanza aprendizaje, lo que conllevo a que se adaptaran de forma rápida, padecieran cambios en su salud, implementaran estrategias de autocuidado y requirieran apoyo de sus familiares, compañeros y amigos.
Bacterias filamentosas productoras de enzimas hidrolíticas aisladas de rizosferas y un sistema de compostaje
Authors: Osorio Echeverri Victor Manuel , Obando García Jessica Johanna , Castrillón Duque Elizabeth Ximena , Martínez José Gregorio 
Published: December 2023

Contextualización: Las hidrolasas son algunas de las enzimas que más se usan en diferentes procesos industriales y se pueden obtener a partir de microorganismos como bacterias y hongos. Las bacterias filamentosas son un grupo de microorganismos presentes en diversos ambientes y muchas de estas especies producen hidrolasas extracelulares que catalizan la descomposición de compuestos como proteínas y polisacáridos. El género más representativo es Streptomyces, un grupo bacteriano que se encuentra en la mayoría de los suelos y que sintetiza enzimas de interés y los principales antibióticos de origen microbiano.
Vacío de conocimiento: La alta diversidad de suelos en el país representa una oportunidad para la bioprospección de microrganismos nativos con potencial enzimático; estos se pueden encontrar en diferentes agroecosistemas poco estudiados y sus capacidades bioquímicas podrían estar asociadas con las condiciones ambientales y nutricionales de los sitios en los que se encuentran.
Objetivo: Verificar la presencia de bacterias filamentosas productoras de enzimas hidrolíticas con potencial aplicación industrial, en diferentes tipos de suelo y en un sistema de compostaje.
Metodología: Se tomaron muestras de un sistema de compostaje, del suelo de un sendero en un bosque nativo y de las rizosferas de un cerco vivo y de cultivos de hortensias, aguacate, mora y coles. Se aislaron bacterias filamentosas a partir de colonias que presentaran la morfología correspondiente. Las actividades enzimáticas se determinaron usando el método de difusión en disco para cuantificar los halos de hidrólisis en medios con almidón, carboximetilcelulosa, gelatina y aceite de oliva.
Resultados y conclusiones: Se obtuvieron 43 aislados de bacterias filamentosas de las cuales 36, 42, 39 y 30 presentaron actividad amilasa, celulasa, gelatinasa y lipasa, respectivamente. En todas las muestras se encontró al menos un aislado con alguna actividad hidrolítica. El sistema de compostaje y la rizosfera del cerco vivo fueron los sitios a partir de los cuales se obtuvieron más aislados bacterianos con mayor actividad, posiblemente relacionada con características como la humedad y la materia orgánica de los suelos de los cuales fueron recuperados.
MODERN MİMARLIĞIN BURSA’DAKİ İZLERİNİ ARAMAK: HALİT FEMİR-FERİDUN AKOZAN İŞ BİRLİĞİ
Authors: OKUMUŞ Gürkan , OKUMUŞ Gökhan 
Published: December 2023

Özet
Halit Femir ve Feridun Akozan’ın dönemin mimarlık ortamı ve Akademi’deki mimar/eğitimcilerin birlikte çalışma geleneği çerçevesinde bir araya gelişi, projelerinin temelini oluşturmaktadır. Dönemin mimarlık pratiğindeki iş birliği kültürü, pek çok ortaklığa ve kolektif üretimler gerçekleştirilmesine olanak tanır. 1942-1954 yılları arasındaki Femir- Akozan ortaklık süreci de çeşitli yapı tipolojilerinden, mimarlık ve tasarım pratiğindeki farklı yaklaşımlara kadar geniş bir mimari üretim yelpazesini kapsamaktadır. Konut, ticaret ve endüstri yapısı, toplu konut yerleşkesi, deniz feneri, kentsel planlama, tarihi dokuda yeni tasarım gibi farklı konularda olmak üzere ikilinin farklı bağlamlarda birçok çalışması bulunmaktadır.
Bu çalışma, Cumhuriyet sonrası dönemde modern mimarlığın Bursa’ya yansımalarını, dönemin mimarlık pratiği ve yapı üretme kültürüne dair verilerle Halit Femir-Feridun Akozan iş birliği üzerinden irdelemeyi hedeflemektedir. İkilinin mimarlık yaklaşımları ve iş birliği süreci birlikte ele alınırken, Bursa’daki farklı bağlam ve ölçeklerdeki İpekçilik Kolektif Şirketi Dokuma Fabrikası, Bay Selim Süter Evi ve Bursa Hal ve Çarşı Binaları’na odaklanılmaktadır. Seçilen bu örnekler, ikilinin mimarlık ve tasarım yaklaşımını farklı ölçeklerde irdelemeyi ve dönemiyle kurduğu referansları sunmayı sağlarken; bu yazıda yapıların tasarım yaklaşımları, kentsel çevredeki tarihsel ve bağlamsal özellikleri, arşiv ve alan çalışmaları ve sözlü görüşmeler aracılığıyla aktarılmaktadır. Bu kapsamda, sınırlı bir bilgiye sahip olunan mimarlar ve çalışmaları hakkında literatüre katkı sağlanması amaçlanmaktadır.
Utility of Peridotite Host Rocks for Sequestering Atmospheric Carbon Dioxide
Authors: Speer Joanna , Matter Juerg , Teagle Damon , James Rachel , Duret Manon , Newman Phil , Plint Neville 
Published: December 2023

Weathering is a natural geological process whereby atmospheric CO2
dissolved in rainwater attacks rocks, partly dissolving them. The
CO is converted into alkalinity or carbonate minerals
that securely store carbon on timescales of >10,000 years.
Modelling studies show that if weathering rates can be increased (by
selecting the most reactive rocks, increasing reactive surface area), up
to an additional 2 Gt CO yr could
be removed from the atmosphere, ~40% of the amount
required by 2100 to meet the Paris Agreement target.
The mining industry extracts gigatonnes of rock each year, generating
large amounts of freshly exposed, reactive surface area that could be
used as a feedstock for enhanced weathering. Ore deposits with the
highest CO removal capacity are those mined in high
quantities that have an abundance of calcium- and magnesium-bearing
silicate minerals [1]. Here, we report the results of an
investigation into the reactivity of serpentinised peridotite samples
from the Sakatti Cu-Ni-PGE deposit (Finland). The deposit consists of
both disseminated and massive sulphides hosted within a large
olivine-cumulate body [2]. The material consists primarily of
serpentine
[MgSiO(OH)]
and olivine [MgSiO] minerals that
have a high potential for CO removal via enhanced
weathering.
We have conducted a series of laboratory experiments whereby crushed
peridotite samples were reacted with CO-enriched
solutions at 25 °C and 50 °C, and 1 bar CO (100%
CO). Surface area normalised dissolution rates were
determined for various grain sizes, temperatures, mineral compositions
(degree of serpentinization) and solution chemistry (with/without a
chelating agent).
Discovery of a Novel Benzothiadiazine-Based Selective Aldose Reductase Inhibitor as Potential Therapy for Diabetic Peripheral Neuropathy
Authors: Jin Ruyi , Wang Jin , Li Mingyue , Tang Tian , Feng Yidong , Zhou Sha , Xie Honglei , Feng Haiyu , Guo Jianshuang , Fu Ruijia , Liu Jiping , Tang Yuping , Shi Yajun , Guo Hui , Wang Yuwei , Nie Fayi , Li Jing 
Published: December 2023

Aldose reductase 2 (ALR2), an activated enzyme in the polyol pathway by hyperglycemia, has long been recognized as one of the most promising targets for complications of diabetes, especially in diabetic peripheral neuropathy (DPN). However, many of the ALR2 inhibitors have shown serious side effects due to poor selectivity over aldehyde reductase (ALR1). Herein, we describe the discovery of a series of benzothiadiazine acetic acid derivatives as potent and selective inhibitors against ALR2 and evaluation of their anti-DPN activities in vivo. Compound 15c, carrying a carbonyl group at the 3-position of the thiadiazine ring, showed high potent inhibition against ALR2 (IC50 = 33.19 nmol/L) and ∼16,109-fold selectivity for ALR2 over ALR1. Cytotoxicity assays ensured the primary biosafety of 15c. Further pharmacokinetic assay in rats indicated that 15c had a good pharmacokinetic feature (t1/2 = 5.60 h, area under the plasma concentration time curve [AUC(0-t)] = 598.57 ± 216.5 μg/mL * h), which was superior to epalrestat (t1/2 = 2.23 h, AUC[0-t] = 20.43 ± 3.7 μg/mL * h). Finally, in a streptozotocin-induced diabetic rat model, 15c significantly increased the nerve conduction velocities of impaired sensory and motor nerves, achieved potent inhibition of d-sorbitol production in the sciatic nerves, and significantly increased the paw withdrawal mechanical threshold. By combining the above investigations, we propose that 15c might represent a promising lead compound for the discovery of an antidiabetic peripheral neuropathy drug.

Article Highlights
Fetal Overgrowth and Preterm Delivery in Women With Type 1 Diabetes Using Insulin Pumps or Multiple Daily Injections: A Post Hoc Analysis of the EVOLVE Study Cohort
Authors: Thorius Ida Holte , Husemoen Lise Lotte N. , Nordsborg Rikke Baastrup , Alibegovic Amra C. , Gall Mari-Anne , Petersen Janne , Damm Peter , Mathiesen Elisabeth R. 
Published: December 2023

OBJECTIVE
To compare the risk of fetal overgrowth and preterm delivery in pregnant women with type 1 diabetes (T1D) treated with insulin pumps versus multiple daily injections (MDI) and examine whether possible differences were mediated through improved glycemic control or gestational weight gain during pregnancy.

RESEARCH DESIGN AND METHODS
The risk of pregnancy and perinatal outcomes were evaluated in a cohort of 2,003 pregnant women with T1D enrolled from 17 countries in a real-world setting during 2013–2018.

RESULTS
In total, 723 women were treated with pumps and 1,280 with MDI. At inclusion (median gestational weeks 8.6 [interquartile range 7–10]), pump users had lower mean HbA1c (mean ± SD 50.6 ± 9.8 mmol/mol [6.8 ± 0.9%] vs. 53.6 ± 13.8 mmol/mol [7.1 ± 1.3%], P &lt; 0.001), longer diabetes duration (18.4 ± 7.8 vs. 14.4 ± 8.2 years, P &lt; 0.001), and higher prevalence of retinopathy (35.3% vs. 24.4%, P &lt; 0.001). Proportions of large for gestational age (LGA) offspring and preterm delivery were 59.0% vs. 52.2% (adjusted odds ratio [OR] 1.36 [95% CI 1.09; 1.70], P = 0.007) and 39.6% vs. 32.1% (adjusted OR 1.46 (95% CI 1.17; 1.82), P &lt; 0.001), respectively. The results did not change after adjustment for HbA1c or gestational weight gain.

CONCLUSIONS
Insulin pump treatment in pregnant women with T1D, prior to the widespread use of continuous glucose monitoring or automated insulin delivery, was associated with a higher risk of LGA offspring and preterm delivery compared with MDI in crude and adjusted analyses. This association did not appear to be mediated by differences in glycemic control as represented by HbA1c or by gestational weight gain.
Jämställdhetsintegrering i högre utbildning
Authors: Salminen Karlsson Minna 
Published: December 2023

"Den mest slående gemensamma nämnaren är hur de flesta kapitlen utgår från erfarenheten och därmed förväntningen att undervisning i jämställdhet kommer att möta motstånd. En hel del av de praktiska råden som finns i flera av kapitlen relaterar också till detta." Läs hela Minna Salminen Karlssons recension av boken Jämställdhetsintegrering i högre utbildning her.
Waiting list changes and follow-up of anti-HCV positive liver transplant recipients: an analysis of 400 cases out of 1000 transplantations
Authors: Syutkin V. E. , Olisov O. D. , Salienko A. A. , Yaremin B. I. , Magomedov K. M. , Lutsyk K. N. , Novruzbekov M. S. 
Published: December 2023

Background. The terminal stages of chronic hepatitis C remain the main indication for liver transplantation in Russia and in the world.Aim. To retrospectively evaluate the changes in the waiting list of liver transplantation that occurred during 22 years of work of the Department for Liver Transplantation at N.V. Sklifosovsky Research Institute for Emergency Medicine in relation to patients with anti-HCV+; and to study the survival rate of anti-HCV+ after liver transplantation, and peculiarities of the course of recurrent HCV infection and virological outcomes of modern antiviral therapy.Material and methods. We analyzed the results of anti-HCV+ liver transplantations from a deceased donors (n=400) operated in the Department for Liver Transplantation at N.V. Sklifosovsky Research Institute for Emergency Medicine for 22 years. Changes in the Waiting List structure, recipient survival and antiviral therapy efficacy were studied.Results. The proportion of anti-HCV+ recipients decreased from 44.3% (period from 2007 to 2019) to 34.1% (from 2020 to 2022, p=0.0027). Survival of anti-HCV+ recipients without HCC is currently comparable to survival of non-infectious non-HCC recipients. The 5-year survival of anti-HCV+ recipients without HCC at the time of liver transplantation was 84%, and the 10-year survival was 76%. The 3and 5-year survival rates of recipients without HCC at the time of liver transplantation who had surgery before August 2016 were lower (80% and 77%, respectively) than the 3and 5-year survival rates (91%) of liver transplant recipients operated on later than this date (p=0.01). Before August 2016, recurrence of HCV infection occurred in > 90% of anti-HCV+ recipients with known HCV RNA status after liver transplantation. Spontaneous clearance of HCV RNA after liver transplantation was observed in 2.1% of cases. In recent years, the incidence of recurrent HCV infection after liver transplantation has decreased significantly (~25% in 2021–22). The use of modern direct acting antiviral regimens results in >95% viral eradication after the 1st course. The emergence of drug resistance polymorphisms in patients who have had unsuccessful experience of direct acting antiviral before liver transplantation is not an obstacle to the success of direct acting antiviral treatment after liver transplantation.Conclusion. The possibility of a rapid and safe cure for HCV infection against the backdrop of a shortage of donor organs necessitates a revision of the documents regulating organ donation, which should make organs from donors with antiHCV in the blood available for transplantation.