bluuebunny/crossref_metadata_2025_split huggingface dataset:
Remission of Chronic Actinic Dermatitis on Baricitinib: A Case Report
Authors: Maguire Jessica , Gleeson David , Corso Roberto , Pink Andrew , Smith Catherine , Ferguson John 
Published: November 2023

Abstract
Chronic actinic dermatitis (CAD) is an immune-mediated photodermatosis characterised by eczematous, pruritic changes to sun-exposed skin. The pathophysiology of CAD is poorly understood, with current explanations including a hypersensitivity reaction and cross-reactivity to contact allergens. The disease is often refractory to immunosuppressive treatment and has a marked impact on patient quality of life. Janus kinase inhibitors (JAKi) are a novel class of small molecules licenced for the management of certain inflammatory conditions, including atopic dermatitis We present the case of a 69-year-old gentleman with a history of severe CAD, unresponsive to standard therapies, who was prescribed baricitinib, a janus kinase (JAK) inhibitor as a single agent treatment for his disease. The patient experienced a dramatic clinical improvement with this therapy. In addition, normalisation of photo test and improvement of patch test results following treatment were observed. There is one previous case report in the literature describing the clinical response of patients with CAD to JAK inhibitor therapy, but no comment on pre or post treatment photo testing, patch testing or photo-patch testing results was made. In this case report, we discuss our understanding of the role of JAK inhibitors in CAD and highlight a potential new therapeutic avenue for this disabling disease.
Easy Recovered Magnetic Bark Biochar for Methylene Blue Removal: Preparation Characterization and Adsorption Parameters Study
Authors: Zeghioud Hicham , Mouhamadou Sali 
Published: November 2023

AbstractIn this study, two types of magnetic biochars (Magnetic Bark Biochar with protocol 1 (MBB1) and Magnetic Bark Biochar with protocol 2 (MBB2)) were synthesized using pristine poplar bark biochar (PBB) via co‐precipitation. The two prepared magnetic biochars were tested to investigate the aqueous methylene blue (MB) removal performances. MB dye was used as a common pollutant for biochar quality evaluation and the obtained performance in this work was compared with literature. Different analysis techniques such as Scanning Electron Microscope (SEM), Energy Dispersive X‐ray Spectroscopy (EDS), Brunauer‐Emmett‐Teller (BET), porosimetry, Raman spectrometry and Fourier Transform Infrared spectroscopy (FTIR) were used to characterize the obtained materials. Biochars have a microporous structure with an average pore diameter of less than 0.26 nm. Magnetization of bark biochar leads to a loss in specific surface area (from 263.45 m2/g for PBB to 39.22 and 73.02 m2/g for MBB1 and MBB2, respectively) and an increase in total porosity by 85.11 and 12.72 %, respectively. MB adsorption process on MBB1 and MBB2 was best described by the pseudo‐first‐order kinetic model (R2=0.98) and by pseudo‐second‐order kinetic model for PBB (R2=0.9). The Langmuir monolayer adsorption and Marczewski‐jaroniec (M‐J) models presented the best fit for both PBB and MBB2 showing favourable adsorption process. Based on maximum adsorption capacity (qm: 32.98 mg/g) and the highest R2 value (0.96), MBB1 adsorption isotherm was well described by Langmuir model. Isotherm study revealed that MBB2 has the highest adsorption capacity of 49.02 mg/g followed by PBB with 37.85 mg/g. MB‐biochar interactions are dominated by chemisorption regarding the PBB and by physisorption concerning the magnetic biochars.
Chemical Cross‐linked Electrode–Electrolyte Interface Boosting the Structural Integrity of High Nickel Cathode Materials
Authors: Zhang Yang , Song Ye , Liu Jie 
Published: November 2023

AbstractHigh nickel cathode material LiNixCoyMn1−x−yO2 (NCM) (x ≥ 0.6) has represented the most critical material in virtue of outstanding specific capacity and low self‐discharge. However, the high surface alkalinity and detrimental interfacial stability lead to the parasitic reaction and a series of phase deterioration. Herein, in situ cross‐linking binder molecular chains with a 3D network structure to construct a stable and robust electrode–electrolyte interface, which can maintain the structural integrity and restrain side reactions is designed. Simultaneously, the cross‐linked polymer can form stable hydrogen bonds with the pristine binder, greatly enhancing the bonding property. More importantly, the functional groups contained in the cross‐linked co‐polymers can chemically anchor transition metals, effectively preventing the dissolution of transition metals. Theoretical calculations confirm the feasibility and advancement of the anchoring mechanism, driving excellent structural stability and inhibition of the NiO impurity phase. This work provides a practical strategy to realize the high stability of cathode materials.
A new taxonomy of global software development best practices using prioritization based on a fuzzy system
Authors: Azeem Akbar Muhammad , Leiva Víctor 
Published: November 2023

AbstractEffective management of development projects is crucial to delivering high‐quality software within time and budget constraints. However, organizing geographically distributed software development activities presents unique challenges, including difficulties in face‐to‐face interaction and coordination. To assist the global software development community in updating and developing new project management techniques, identifying and prioritizing best practices is essential. This study aims to develop a taxonomy based on the prioritization of management practices for software development, drawing from empirical data. Fifty‐five best practices associated with the Project Management Body of Knowledge (PMBOK) fields were identified from the existing literature. The study also empirically examines the acceptability and relevance of these practices within the industry. An analytic hierarchy process within a fuzzy system is employed to prioritize these practices based on their importance in managing global software development.
Psychological Wellbeing
Authors: Eleuteri Stefano , de Lima Maria Eduarda Batista 
Published: November 2023

AbstractHip fracture (HF) patients are among the most vulnerable of hospitalised patients. In this chapter, we will illustrate why the psychological status of patients is important in the management and outcome of hip fracture, how it should be assessed and how it could be positively influenced by the orthogeriatric team. The chapter aims to provide an overview of the causes of negative psychological status, provide advice on strategies that can be used to identify those at risk and give examples of assessments and interventions to aid diagnosis and treatment. The focus will be on problematic aspects but will also comment on how positive dimensions in psychology, such as motivation, can impact on patient recovery.
Preventing Falls
Authors: Perracini Monica Rodrigues , Lima Camila Astolphi , Santy-Tomlinson Julie , Sherrington Cathie 
Published: November 2023

AbstractA fall is the mechanism of injury for most fragility fractures. Falls are preventable and should not be viewed as an inevitable consequence of the ageing process. Falls and fragility fractures frequently result in both short- and long-term disability and can be life-changing with considerable deterioration in health-related quality of life, increased dependency and social isolation.The causes of falls are individual and multifactorial. Risk factors interact dynamically and can be broadly classified into three main categories: demographic, intrinsic and extrinsic. Frailty, sarcopenia, falls and fragility fractures are linked and should be identified and receive proper intervention.Evidence-based processes and tools for interdisciplinary screening, assessment and management of risk of falling are available and can guide healthcare professionals. Involving patients and their families is essential in developing and implementing a person-centred fall prevention care plan. Nurses are central to fall prevention strategies in both hospital and community settings, working collaboratively with the entire interdisciplinary team, but most often with physiotherapists.The aim of this chapter is to explore the role of the practitioner working in acute hospital units, ambulatory care/outpatient clinics and community/home care settings and with people transitioning from hospital to home in preventing further falls in older people who have sustained a fragility fracture.
Fermions with SU(1, n) spacetime symmetry
Authors: Smith Joseph 
Published: November 2023

Abstract
We construct theories of free fermions in (2n − 1)-dimensions with SU(1, n) spacetime symmetry from the null reduction of fermions on a 2n-dimensional Ω-deformed Minkowski background for n = 2 and n = 3. These play a role in the 5d SU(1, 3)-invariant theories that are conjectured to offer a full description of certain 6d superconformal field theories. We find the (2n − 1)-dimensional manifestation of the supersymmetry of a free 2n-dimensional boson-fermion system, which we use to fix the fermion two-point functions. It is then shown that the full 2n-dimensional two-point function can be recovered through resummation. Limits of the theories are considered, and it is observed that both Galilean and Carrollian field theories appear in different regimes. We confirm that the correlation functions obey the SU(1, n) Ward identities and the representations of the fermions under this group are discussed.
Repair of medial meniscus posterior root tear is effective for root healing and cartilage regeneration in opening wedge high tibial osteotomy
Authors: Choi Yun Seong , Chang Moon Jong , Lee Ji Han , Lee Jae Hee , D’Lima Darryl D. , Kim Tae Woo , Chang Chong Bum , Kang Seung‐Baik 
Published: November 2023

AbstractPurposeThis study aimed to determine whether the repair of a medial meniscus posterior root tear (MMPRT) is effective for MMPRT healing, cartilage regeneration, and clinical outcomes in opening wedge high tibial osteotomy (OWHTO).MethodsThis retrospective study included 80 patients who underwent OWHTO and subsequent second‐look arthroscopy. The patients were divided into OWHTO‐with‐MMPRT‐repair (n = 40) and OWHTO alone (n = 40) groups, and the healing rates (complete/partial/failure) were compared. Each group was further divided into over‐ and under‐corrected subgroups to compare healing rates. The International Cartilage Repair Society (ICRS) grade, cartilage defect size, Koshino stage, ICRS cartilage repair assessment score of the medial femoral condyle (MFC), and International Knee Documentation Committee (IKDC) scores between the OWHTO‐with‐MMPRT‐repair and OWHTO alone groups were compared according to whether microfracture was performed on the MFC.ResultsThe overall healing rate of the MMPRT was higher in the OWHTO‐with‐MMPRT‐repair group than that in the OWHTO alone group (P < 0.001). In addition, in the subgroup analysis, no difference in the MMPRT healing rate between the over‐correction and under‐correction groups when MMPRT repair was performed (n.s). In contrast, without MMPRT repair, the healing rate was lower in the under‐correction group than that in the over‐correction group (P = 0.03). Cartilage regeneration of the OWHTO‐with‐MMPRT‐repair group was superior to that of the OWHTO alone group (P < 0.05). The IKDC subjective scores of the OWHTO‐with‐MMPRT‐repair and OWHTO alone groups were 34.5 and 33.1 before surgery (n.s) and 50 and 47.2 at one year after surgery, respectively (n.s). These differences between the two groups for cartilage regeneration and IKDC subjective scores showed the same pattern regardless of microfractures.ConclusionsMMPRT repair during OWHTO might improve MMPRT healing, even with under‐correction, and cartilage regeneration of MFC, regardless of microfracture. However, OWHTO with MMPRT repair might not improve short‐term clinical outcomes compared to OWHTO alone. Further randomized clinical trials are necessary.Level of evidenceIII, Retrospective cohort study.
The role of anti-diabetic drugs in NAFLD. Have we found the Holy Grail? A narrative review
Authors: Zachou Maria , Flevari Pagona , Nasiri-Ansari Narjes , Varytimiadis Constantinos , Kalaitzakis Evangelos , Kassi Eva , Androutsakos Theodoros 
Published: November 2023

Abstract
Purpose
Non-alcoholic fatty liver disease (NAFLD) has become a leading cause of liver disease, affecting 30% of the global population. NAFLD prevalence is particularly high in obese individuals and patients with type 2 diabetes mellitus (T2DM). NAFLD ranges from simple fat deposition in the liver to necroinflammation and fibrosis (non-alcoholic steatohepatitis (NASH)), NASH-cirrhosis, and/or hepatocellular carcinoma. Insulin resistance plays a key role in NAFLD pathogenesis, alongside dysregulation of adipocytes, mitochondrial dysfunction, genetic factors, and changes in gut microbiota. Since insulin resistance is also a major predisposing factor of T2DM, the administration of anti-diabetic drugs for the management of NAFLD seems reasonable.

Methods
In this review we provide the NAFLD-associated mechanisms of action of some of the most widely used anti-diabetic drugs, namely metformin, pioglitazone, sodium-glucose transport protein-2 inhibitors (SGLT2i), glucagon-like peptide 1 receptor analogs (GLP1 RAs), and dipeptyl-peptidase-4 inhibitors (DPP4i) and present available data regarding their use in patients with NAFLD, with and without T2DM.

Results
Both metformin and DPP4i have shown rather contradictory results, while pioglitazone seems to benefit patients with NASH and is thus the only drug approved for NASH with concomitant significant liver fibrosis by all major liver societies. On the other hand, SGLT2i and GLP1 RAs seem to be beneficiary in patients with NAFLD, showing both remarkable results, with SGLT2i proving to be more efficient in the only head-to-head study so far.

Conclusion
In patients with NAFLD and diabetes, pioglitazone, GLP1 RAs, and SGLT2i seem to be logical treatment options. Larger studies are needed before these drugs can be recommended for non-diabetic individuals.
Annexin A5 stabilizes matrix vesicle-biomimetic lipid membranes: unravelling a new role of annexins in calcification
Authors: Ferreira Claudio R. , Cruz Marcos Antônio E. , Bolean Maytê , Andrilli Luiz Henrique da S. , Millan José Luis , Ramos Ana Paula , Bottini Massimo , Ciancaglini Pietro 
Published: November 2023

AbstractMatrix vesicles are a special class of extracellular vesicles thought to actively contribute to both physiologic and pathologic mineralization. Proteomic studies have shown that matrix vesicles possess high amounts of annexin A5, suggesting that the protein might have multiple roles at the sites of calcification. Currently, Annexin A5 is thought to promote the nucleation of apatitic minerals close to the inner leaflet of the matrix vesicles’ membrane enriched in phosphatidylserine and Ca2+. Herein, we aimed at unravelling a possible additional role of annexin A5 by investigating the ability of annexin A5 to adsorb on matrix-vesicle biomimetic liposomes and Langmuir monolayers made of dipalmitoylphosphatidylserine (DPPS) and dipalmitoylphosphatidylcholine (DPPC) in the absence and in the presence of Ca2+. Differential scanning calorimetry and dynamic light scattering measurements showed that Ca2+ at concentrations in the 0.5–2.0 mM range induced the aggregation of liposomes probably due to the formation of DPPS-enriched domains. However, annexin A5 avoided the aggregation of liposomes at Ca2+ concentrations lower than 1.0 mM. Surface pressure versus surface area isotherms showed that the adsorption of annexin A5 on the monolayers made of a mixture of DPPC and DPPS led to a reduction in the area of excess compared to the theoretical values, which confirmed that the protein favored attractive interactions among the membrane lipids. The stabilization of the lipid membranes by annexin A5 was also validated by recording the changes with time of the surface pressure. Finally, fluorescence microscopy images of lipid monolayers revealed the formation of spherical lipid-condensed domains that became unshaped and larger in the presence of annexin A5. Our data support the model that annexin A5 in matrix vesicles is recruited at the membrane sites enriched in phosphatidylserine and Ca2+ not only to contribute to the intraluminal mineral formation but also to stabilize the vesicles’ membrane and prevent its premature rupture.
Current use of percutaneous image-guided tumor ablation for the therapy of liver tumors: lessons learned from the registry of the German Society for Interventional Radiology and Minimally Invasive Therapy (DeGIR) 2018–2022
Authors: Zensen Sebastian , Bücker Arno , Meetschen Mathias , Haubold Johannes , Opitz Marcel , Theysohn Jens M. , Schramm Sara , Jochheim Leonie , Kasper Stefan , Forsting Michael , Schaarschmidt Benedikt Michael 
Published: November 2023

Abstract
Objectives
Percutaneous image-guided tumor ablation of liver malignancies has become an indispensable therapeutic procedure. The aim of this evaluation of the prospectively managed multinational registry of the voluntary German Society for Interventional Radiology and Minimally Invasive Therapy (DeGIR) was to analyze its use, technical success, and complications in clinical practice.

Materials and methods
All liver tumor ablations from 2018 to 2022 were included. Technical success was defined as complete ablation of the tumor with an ablative margin.

Results
A total of 7228 liver tumor ablations from 136 centers in Germany and Austria were analyzed. In total, 31.4% (2268/7228) of patients were female. Median age was 67 years (IQR 58–74 years). Microwave ablation (MWA) was performed in 65.1% (4703/7228), and radiofrequency ablation (RFA) in 32.7% (2361/7228). Of 5229 cases with reported tumor etiology, 60.3% (3152/5229) of ablations were performed for liver metastases and 37.3% (1950/5229) for hepatocellular carcinoma. The median lesion diameter was 19 mm (IQR 12–27 mm). In total, 91.8% (6636/7228) of ablations were technically successful. The rate of technically successful ablations was significantly higher in MWA (93.9%, 4417/4703) than in RFA (87.3%, 2061/2361) (p < 0.0001). The total complication rate was 3.0% (214/7228) and was significantly higher in MWA (4.0%, 189/4703) than in RFA (0.9%, 21/2361, p < 0.0001). Additional needle track ablation did not increase the rate of major complications significantly (24.8% (33/133) vs. 28.4% (23/81), p = 0.56)).

Conclusion
MWA is the most frequent ablation method. Percutaneous image-guided liver tumor ablations have a high technical success rate, which is higher for MWA than RFA. The complication rate is generally low but is higher for MWA than RFA.

Clinical relevance statement
Percutaneous image-guided liver ablation using microwave ablation and radiofrequency ablation are effective therapeutic procedures with low complication rates for the treatment of primary and secondary liver malignancies.

Key Points
• Percutaneous image-guided liver tumor ablations have a high technical success rate, which is higher for microwave ablation than radiofrequency ablation.
• Microwave ablation is the most frequent ablation method ahead of radiofrequency ablation.
• The complication rate is generally low but is higher for microwave ablation than radiofrequency ablation.
Metal–organic framework-reduced graphene oxide (Zn-BDC@rGO) composite for selective discrimination among ammonia, carbon monoxide, and sulfur dioxide
Authors: More Mayuri S. , Bodkhe Gajanan A. , Singh Fouran , Kim Myunghee , Shirsat Mahendra D. 
Published: November 2023

AbstractThe structural diversity and high surface reactivity of the metal–organic frameworks (MOFs) offer an ideal material platform for various applications such as gas storage, gas separation, catalyst, etc. However, their use in chemiresistive gas sensing is limited due to the requirement of optimized gas adsorption properties with electrical conductivity. In the present investigation, we have modulated the electrical properties of zinc benzene dicarboxylate (Zn-BDC) MOF by modifying it with partially reduced graphene oxide (rGO). The Zn-BDC and rGO composite (Zn-BDC@rGO) was synthesized by utilizing a solvothermal method and multiparametrically tested by various techniques such as X-Ray diffraction (XRD), UV–visible spectroscopy, Raman spectroscopy, Fourier transform infrared spectroscopy (FTIR), atomic force microscopy (AFM), thermogravimetric analysis (TGA), and I–V characteristics, for its structural, spectroscopic, morphological, surface area analysis, thermal stability, and electrical characterization, respectively. The synthesized Zn-BDC@rGO composite was deposited via drop casting method on the copper electrodes on a glass substrate (100 µm gap) using the shadow mask technique by the e-beam evaporator, and tested for the detection of ammonia, carbon monoxide, and sulfur dioxide using chemiresistive modality. The principal component analysis (PCA) indicates that the developed sensor selectively discriminates among the NH3, CO, and SO2 gases with low response/recovery time, i.e., 60/120 s at 20 ppm, which is far below the permissible exposure limit (PEL) suggested by The Occupational Safety and Health Administration (OSHA), USA for CO and NH3 and very close to the PEL level of SO2.
Enhanced recovery after surgery (ERAS) protocol improves patient outcomes in free flap surgery for head and neck cancer
Authors: Nieminen Teija , Tapiovaara Laura , Bäck Leif , Lindford Andrew , Lassus Patrik , Lehtonen Lasse , Mäkitie Antti , Keski-Säntti Harri 
Published: November 2023

Abstract
Background
In recent years, enhanced recovery after surgery (ERAS) guidelines have been developed to optimize pre-, intra-, and postoperative care of surgical oncology patients. The aim of this study was to compare management outcome of patients undergoing head and neck cancer (HNC) surgery with free flap reconstruction at our institution before and after the implementation of the ERAS guidelines.

Methods
This retrospective study comprised 283 patients undergoing HNC surgery with free flap reconstruction between 2013 and 2020. Patients operated before and after the implementation of the ERAS protocol in October 2017 formed the pre-ERAS group (n = 169), and ERAS group (n = 114), respectively.

Results
In the pre-ERAS group the mean length of stay (LOS) and intensive care unit length of the stay (ICU–LOS) were 20 days (range 7–79) and 6 days (range 1–32), and in the ERAS group 13 days (range 3–70) and 5 days (range 1–24), respectively. Both LOS (p < 0.001) and ICU–LOS (p = 0.042) were significantly reduced in the ERAS group compared to the pre-ERAS group. There were significantly fewer medical complications in the ERAS group (p < 0.003). No difference was found between the study groups in the surgical complication rate or in the 30-day or 6-month mortality rate after surgery.

Conclusions
We found reduced LOS, ICU–LOS, and medical complication rate, but no effect on the surgical complication rate after implementation of the ERAS guidelines, which supports their use in major HNC surgery.