bluuebunny/crossref_metadata_2025_split huggingface dataset:
Synthesis of phosphaphenanthrene derivatives as flame retardants and their properties in epoxy resin composites
Authors: Qi Yuzhao , Huan Xuanying , Xu Qiu , Bao Dongmei , Zhang Daohai , Zhou Guoyong , Zhang Yupeng , Du Haijun 
Published: January 2024

AbstractIn order to further improve the flame‐retardant properties of epoxy resins (EPs), two hydroxyl‐containing phospha‐phenanthrene derivatives, DOPO‐PHBA and DOPS‐PHBA, were prepared from the molecular structure design by using 9,10‐dihydro‐9‐oxa‐10‐phospha‐phenanthrene‐10‐oxide (DOPO), 9,10‐dihydro‐9‐oxa‐10‐phosphaphenanthrene‐10‐sulfide (DOPS), and 4‐hydroxybenzaldehyde (PHBA) as the raw materials. These composites of DOPO‐PHBA/EP and DOPS‐PHBA/EP were prepared by melt blending. The results showed that UL‐94 V‐0 was achieved with an LOI of 31.9% when just 7.5% DOPS‐PHBA was added to EP, while a limited oxygen index of 35.2% was achieved with 10% DOPO‐PHBA/EP. Moreover, in comparison with 7.5% DOPO‐PHBA/EP, 7.5% DOPS‐PHBA/EP has the lower peak of heat release rates, total heat release values, and fire growth rate, demonstrating that the flame‐retardant DOPS‐PHBA is more effective at reducing heat release, enhancing the material's flame retardancy, and lessening the intensity of EP burning. The Thermogravimetric‐infraredspectrometry (TG‐IR) results showed that the phosphorus‐containing radicals generated by DOPS‐PHBA/EP pyrolysis trapped the free radicals, such as H˙, O˙, or HO˙, thus providing free radical quenching. Furthermore, combining the macro and micro Scanning electron microscopy (SEM) test results, DOPS‐PHBA/EP has a better char formation ability and a denser char layer, which can play a better role in heat and oxygen insulation.
Novel large‐scale mapping highlights poor state of sea trout populations
Authors: Fiske Peder , Forseth Torbjørn , Thorstad Eva B. , Bakkestuen Vegar , Einum Sigurd , Falkegård Morten , Garmo Øyvind A. , Garseth Åse Helen , Skoglund Helge , Solberg Monica , Utne Kjell Rong , Vollset Knut Wiik , Vøllestad Leif Asbjørn , Wennevik Vidar 
Published: January 2024

Abstract

The state of sea trout in 1251 Norwegian watercourses was assessed based on a scoring system for human pressures, abundance data, and local knowledge.
Over 16,000 km of rivers and lakes were available to sea trout in these watercourses, spanning from the temperate to Arctic regions.
Sea trout were classified to be in a good or very good state in fewer than 25% of the watercourses and in a poor or very poor state in almost 40%. Twenty‐nine watercourses had lost their sea trout populations.
Salmon lice from aquaculture salmon farms had by far the largest adverse effect on sea trout among the human impact factors, both in the number of watercourses (83%) and river area affected (60%), and the total effect on sea trout abundance.
Agriculture and hydropower production also had strong adverse impacts (35% and 19% of watercourses), but substantially lower than that caused by salmon lice. Culverts related to road crossings and other habitat alterations also had impacts on sea trout in many watercourses (27%).
Exploitation of sea trout has been reduced in Norway in recent years, both in the marine and freshwater fisheries. Yet, the exploitation pressure was moderate or high in almost 14% of the watercourses where the state of sea trout was poor or very poor, suggesting a high potential for overexploitation in these.
The state of sea trout was best in the northern sparsely populated areas. However, distribution of watercourses with sea trout in a poor or very poor state was more linked to aquaculture, agriculture, and hydropower production than human population density.
The developed approach for large‐scale mapping of state and pressures, which is vital for prioritizing management measures, may inspire other nations in their conservation effort for this important species.
Honoring human body donors: Five core themes to consider regarding ethical treatment and memorialization
Authors: Leeper Bobbie J. , Grachan Jeremy J. , Robinson Rhiannon , Doll Julie , Stevens Kelsey 
Published: January 2024

AbstractDissection of human body donors is a common component of anatomy curricula, as it provides opportunities for tactile and intellectual engagement unmatched otherwise. Additionally, interaction with human body donors contributes to the “hidden curriculum” of allowing students to begin to ethically practice patient care with empathy, respect, and compassion. With this, there have been various proposed guidelines for the ethical treatment of human body donors, with most focusing on student reflections and a final ceremony for honoring the donors, but there are numerous other ways throughout the course to incorporate ethical values and to guide students to consider the humanity of the donor. This article proposes that institutions consider the incorporation of five easily implemented formalized ethical themes for working with human body donations into daily practices: (1) reflect the donor as possessing human dignity, (2) recognize the donor's role of the “First Patient” or “Silent Teacher,” (3) honor the gift of human body donation, (4) recognize the decedent's family, and (5) consider inclusivity in memorialization practices. Multiple recommendations for integrating these five themes throughout the course are provided. The incorporation of these five core themes can assist in alleviating the psychological stress that some students struggle with in dissection courses, foster the feelings and attributes that comprise the hidden curriculum and are the desired characteristics of a caring medical provider, and discourage misuse and mistreatment of donors.
A Comprehensive Workflow towards More Equant‐Shaped Crystals of Active Pharmaceutical Ingredients
Authors: Ramos Ojeda Nicolás Antonio , Kind Matthias 
Published: January 2024

AbstractThe morphology of crystalline active pharmaceutical ingredients (APIs) can significantly affect their product properties, so that its control during manufacturing is crucial. To address this, a newly augmented commercial milliliter‐scale facility and knowledge‐based workflow were developed with the aim of identifying optimal process conditions for producing more equant‐shaped crystals. The design includes minimal material usage, inline imaging, and independent temperature and supersaturation control through evaporative crystallization. The methodology enables the identification of process conditions for equant‐shaped crystals across diverse APIs. These findings contribute to advancing pharmaceutical research and development by providing a reliable approach to optimize crystal morphology.
Switching Product Selectivity in Immobilized Tungstate Catalysts by Control of Hydrophobicity of Mesoporous Silicate Supports
Authors: Kuwamoto Ko , Okamura Masaya , Hikichi Shiro 
Published: January 2024

AbstractNovel mesoporous silicates modified with imidazolium cation were applied as the support for peroxotungstate. Stepwise introduction of multiple functional groups to SBA‐15 was achieved by the combination of the direct and post‐synthesis procedures. The co‐condensation of tetraethoxysilane and 3‐(imidazolyl‐1‐yl)‐propyltriethoxysilane in the presence of the micelles of an amphiphilic surfactant yields the hydrophilic SBA‐15 type silicate support with the imidazole modifier locating into the mesopores. The hydrophobic environment of the supports was imparted by capping the residual silanols on the silicate surface with trimethylsilyl groups. The fluoroalkyl‐ or alkyl‐imidazolium cation‐anchored supports were derived from the corresponding imidazole‐functionalized precursors. The anion‐exchanging reaction between peroxytungstate and the imidazolium cation‐anchored supports yielded the corresponding tungstate‐immobilized catalysts. The hydrophilic catalyst with the fluoroalkyl‐imidazolium mediated alkene epoxidation with H2O2 in less polar solvents. The hydrophobic one, in contrast, produced diol through the epoxidation and following hydration in an aqueous solvent by the action of the highly Lewis acidic tungsten. The hydrophobic catalysts had the advantage of being more tolerant than hydrophilic catalysts, as evidenced by reusability tests. The activities of the alkyl‐imidazolium catalysts were lower than those of the corresponding fluoroalkyl‐imidazolium catalysts, indicating that the local structures surrounding the tungstate site affected the catalytic performance.
Central Ring Puckering Enhances the Stokes Shift of Xanthene Dyes
Authors: Dunlop David , Horváth Peter , Klán Petr , Slanina Tomáš , Šebej Peter 
Published: January 2024

AbstractSmall‐molecule dyes are generally designed based on well‐understood electronic effects. However, steric hindrance can promote excited‐state geometric relaxation, increasing the difference between the positions of absorption and emission bands (the Stokes shift). Accordingly, we hypothesized that sterically induced central ring puckering in xanthene dyes could be used to systematically increase their Stokes shift. Through a combined experimental/quantum‐chemical approach, we screened a group of (9‐acylimino)‐pyronin dyes with a perturbed central ring geometry. Our results showed that an atom with sp3 hybridization in position 10 of (9‐acylimino)‐pyronins induces central ring puckering and facilitates excited‐state geometric relaxation, thereby markedly enhancing their Stokes shifts (by up to ~2000 cm−1). Thus, we prepared fluorescent (9‐acylimino)‐pyronin pH sensors, which showed a Stokes shift disparity between acid and base forms of up to ~8700 cm−1. Moreover, the concept of ring puckering‐enhanced Stokes shift can be applied to a wide range of xanthene analogues found in the literature. Therefore, central ring puckering may be reliably used as a strategy for enhancing Stokes shifts in the rational design of dyes.
Nomogram predicts survival and surgical benefits for patients with breast cancer with initial bone metastasis: A population‐based study
Authors: Zhou Xingtong , Liu Mohan , Zheng Zhibo , Cao Xi , Lin Yan , Xu Ying , Li Yan , Wang Hayson Chenyu , Sun Qiang 
Published: January 2024

AbstractBackgroundPrimary stage IV breast cancer is associated with a poor prognosis. At present, the value of local surgical treatment for patients with stage IV breast cancer remains uncertain; therefore, treatment principles remain controversial. Because of the high heterogeneity of these patients, it is often difficult to evaluate their prognoses. As a result, this study aimed to establish a prognostic nomogram to evaluate the prognosis of patients with breast cancer experiencing primary bone metastasis.MethodsThe clinical characteristics and follow‐up data of patients with primary breast cancer and bone metastasis from 2010 to 2018 were collected from the Surveillance, Epidemiology, and End Results database and from 2013 to 2021 at the Peking Union Medical College Hospital. Patients were divided into training and validation groups. Multivariate Cox regression analysis was used to identify the independent prognostic variables for predicting cancer‐specific survival (CSS). On the basis of these independent risk factors, a nomogram was developed and used calibration curves to evaluate its accuracy. Patients were divided into three risk groups according to their scores and surgery‐related survival curves plotted using the log‐rank test.ResultsOverall, 6372 patients were included, with 6319 from the Surveillance, Epidemiology, and End Results database and 53 from the Peking Union Medical College Hospital Breast Surgery Department. Multivariate analysis showed that age, race, marital status, grade, tumor stage, estrogen receptor status, progesterone receptor status, human epidermal growth factor receptor 2 status, and burden of other metastatic lesions were all associated with CSS. Based on these results, a nomogram that predicted the 1‐, 3‐, and 5‐year CSS rates in patients with primary breast cancer and bone metastasis (concordance index > 0.69) was developed. After dividing patients into low‐risk, high‐risk, or super‐high‐risk groups based on nomogram scoring criteria, survival analysis revealed that patients in the low‐ and high‐risk groups had significant survival benefits from primary focal surgery.ConclusionIndependent risk factors for primary breast cancer in patients with bone metastasis were analyzed and a nomogram established to predict CSS. The prognostic tool derived in this study can assist clinicians in predicting the survival and surgical benefits of these patients through scoring, thereby providing further guidance for treatment strategies.
Histodenz Separation of Lysosomal Subpopulations for Analysis of Chaperone‐mediated Autophagy
Authors: Burns Calvin M. , Miller Richard A. , Endicott S. Joseph 
Published: January 2024

AbstractChaperone‐mediated autophagy (CMA) is the most selective form of lysosomal proteolysis, in which proteins are individually selected for lysosomal degradation. CMA degradation targets bear a pentapeptide consensus motif that is recognized by the cytosolic chaperone HSPA8 (Hsc70), which participates in the trafficking of the target to the lysosomal surface. From there, it is translocated into the lysosomal lumen, independent of vesicle fusion, in a process dependent upon the lysosomal transmembrane protein LAMP2A. There are limited tools for studying CMA in whole cells and tissues, and many of the best techniques for studying CMA rely on the preparation of lysosome enriched fractions. Such experiments include (1) the in vitro evaluation of CMA substrate uptake activity, (2) the characterization of changes to lysosomal resident and CMA regulatory proteins, and (3) lysosomal targetomics, i.e., the use of quantitative proteomics to characterize lysosomal degradation targets. Previous studies using discontinuous metrizamide gradients have shown that a subpopulation of liver lysosomes is responsible for the majority of CMA activity (“CMA+”). These CMA+ lysosomes are low density and have higher levels of MTORC2 relative to the “CMA–” lysosomes, which are high density and have higher levels of MTORC1. Because of safety concerns surrounding metrizamide, however, this compound is difficult to obtain, and it is impractically expensive. Here, we have provided protocols for isolation of lysosomal subpopulations for CMA‐related analyses from mouse liver using Histodenz, a safe and affordable alternative to metrizamide. Supplementary protocols show how to perform CMA activity assays with appropriate statistical analysis, and how to analyze for lysosomal breakage/membrane integrity. © 2024 The Authors. Current Protocols published by Wiley Periodicals LLC.Basic Protocol: Isolation of lysosomal subpopulations from mouse liver using discontinuous Histodenz gradientsAlternate Protocol: Isolation of lysosomes from cultured cells using discontinuous Histodenz gradientsSupport Protocol 1: Verifying enrichment of lysosomal markers in lysosome‐enriched fractionsSupport Protocol 2: Measuring in vitro uptake of CMA substratesSupport Protocol 3: Measuring lysosomal membrane integrity by hexosaminidase assay
A modified modular multilevel converter to reduce the second order ripples in the submodule capacitor voltage: Design and analysis
Authors: Ganji Ramudu , Singh Jiwanjot 
Published: January 2024

SummaryThe modular‐multilevel converter (MMC) faces the problem of second order ripples in the sub‐module DC capacitor voltage during the low frequency operation at the load side. To sort out this problem, this paper demonstrates a three‐phase modified MMC that includes a novel circuit placed between upper and lower arms of each phase, where load is connected through proposed circuit. The aim of the proposed circuit is to reduce the magnitude of the ripples in each sub‐module's DC capacitor voltage; moreover, it also uses a less number of components compared with the conventional circuits. In order to keep the capacitor voltage at its rated value and to prevent the development of common mode voltage, the proposed circuit uses the high frequency‐based power transfer control channel for balancing power between the upper or top and lower or bottom arms. Furthermore, the mathematical analysis, operating principle, and proposed control is explained in detail for the conventional MMC and modified MMC. The simulation results have been obtained for the modified MMC with resistive load by using MATLAB and Simulink. An experimental test results have been verified with simulation results for the modified MMC topology.
Ammonia emissions from livestock facilities around an international airport, Tehran, Iran: An experimental and mathematical study
Authors: Asadollahfardi Gholamreza , Khoormehr Danial , Sarmadi Mohammad Sina , Mirmohammadi Mohsen 
Published: January 2024

AbstractAmmonia emissions from livestock farms are a major problem for staff and residents near these centers. Anaerobic decomposition of livestock waste and the collection and stacking of waste are the main sources of ammonia gas on livestock farms. This article examined ammonia emissions from livestock facilities near Tehran Imam Khomeini International Airport. First, field measurements were made in the summer (30°C), and collected samples were examined using the indophenol technique. AERMOD, based on Gaussian fluctuating plume theory, was constructed to model ammonia emissions. According to AERMOD, the maximum periodic‐seasonal 2‐hourly and 8‐hourly ammonia concentrations were 15.9, 229, and 63.7 OU (odor unit per unit volume)/m3, respectively. The hourly ammonia emission rate from livestock sources is also 0.0168 gm−2 h−1. AERMOD results mathematical model indicated reasonable agreement with the field measurement, which the coefficient of determination (R2), index of agreement (d), and efficiency coefficient (E) were 0.95, 0.97, and 0.91, respectively. Moreover, Statistical indices, including geometric mean bias (MG), geometric variance (VG), fraction of predictions within a factor of two of observations (FAC2), and normalized mean square error (NMSE), the root mean square error (RMSE) and mean absolute error (MAE) are also indicated by 1.36 and 0.67, respectively, were used to assess the reliability of the model results showed that AERMOD had a good agreement with the field measurement.
Infringements of European Union law at the local and regional level across Member States
Authors: Clinton Peter , Arregui Javier 
Published: January 2024

AbstractThis paper investigates variations in infringements of EU rules by substate authorities. The paper tests the effect of structure and actor level variables. First, we test structural factors in terms of the autonomy that substate authorities hold. Second, we test some actor level factors that may also increase transaction costs: autonomy of substate actors, public opinion on the EU and administrative capacity. The results indicate that there is a relationship between the increased autonomy of substate authorities and higher number of infringements. The results also provide support that preference to exercise this autonomy correlates with higher infringements. In addition, the results show that negative public opinion on the EU is strongly correlated to higher numbers of infringements. This suggests that transaction costs associated with multilevel policy implementation and attitudes to the EU are determinants of substate infringements.
Study on the new layout pattern about the gob‐side entry under dynamic pressure and its surrounding rock stability control
Authors: Wang Meng , Wang Wenyu , Xu Yalong , Xie Guoliang , Qin Jianyun , Liu Honglin , Wei Sijiang , Xu Qingyun 
Published: January 2024

AbstractThough the recovery rate of coal resources can be effectively improved by adopting the gob‐side entry longwall face, which is also easy to cause tension between mining and excavation. Therefore, a new type of roadway layout, narrow coal pillar entry retained (NCPER), was invented in the study. The NCPER is excavated together with the tailgate of next longwall face before the mining of prior longwall face, which is retained and reused during the mining of the next longwall face. The layout is based on the advantages and successful experience of the double roadways excavation, the gob‐side entry retained, and the roadway driven along gob‐side and heading for adjacent advancing coal face; moreover, the NCPER significantly shortens the preparation time of the longwall face while improving the recovery rate. Taking the production geological conditions of Yushuling Mine as the engineering background, the influence of factors such as roof‐cutting pressure relief and coal pillar width on the stability of the narrow coal pillar from the perspective of improving the stress environment of the roadway and strengthening the weak structure support of the surrounding rock was studied, and reasonable suggestions for selecting parameters of roof cutting and coal pillar width were given. Furthermore, the bidirectional grouting cable and its joist were used to strengthen the narrow coal pillar and the roadway roof, respectively, and a good effect of roadway control has been obtained. The invention and application of NCPER provided a new approach for the longwall face roadway layout and effectively eased the strained relationship between mining and excavating, which has a strong popularization and application value.
Oscillating body wave energy conversion efficiency based on Simulink simulation training
Authors: Yin Yue , Lu Zhicheng , Li Yutao , Huang Weinuo , Huang Hongyi , Zhang Chi , Wu Qi‐Hui , Wu Minfeng 
Published: January 2024

AbstractWith the development of the economy and society, we are faced with the dual challenges of energy demands and environmental pollution. As one of the important marine renewable energies, wave energy is widely distributed and abundant, and has considerable applications in various fields. Oscillating body wave energy converter (WEC) is most popular among WECs; its energy conversion efficiency is thus one of the key issues for practical large‐scale applications. This article establishes a new model of the float and vibrator under different motion conditions, conducts simulation training, and then solves the displacement and velocity at different times, and finally optimizes the maximum output power and optimal damping coefficient. Simulink calculation is one of the most effective tools including neural networks, which allows us to achieve intelligent training and simulation. The obtained data imply that the maximum output power could be 8.102 W when the corresponding linear damping is 21,000 N s/m and the rotation damping is 95,000 N s/m. The article takes into account the pitching motion of the float, providing a more realistic model and obtaining optimal power absorbing efficiency. The obtained results could be the potential reference data in practically setting up the wave energy conversion systems.