bluuebunny/crossref_metadata_2025_split huggingface dataset:
Surveillance of antimicrobial resistance in the United Arab Emirates: the early implementation phase
Authors: Thomsen Jens , Abdulrazzaq Najiba M. , AlRand Hussain ,   The UAE AMR Surveillance Consortium
Published: November 2023

IntroductionNational surveillance of antimicrobial resistance (AMR) is an important public health function. Published national AMR surveillance data from the Middle East/North Africa (MENA) region is scarce. This paper describes the early implementation phase of establishing AMR surveillance in the United Arab Emirates (UAE).Materials and methodsBuilding on the existing AMR surveillance system in the Emirate of Abu Dhabi, and adopting the WHO-GLASS methodology, the UAE Ministry of Health and Prevention (MOHAP) established the national AMR Surveillance program in 2015, in collaboration with regional health authorities and healthcare providers. Main objectives of this program are to (a) set AMR surveillance standards, (b) collect and analyze AMR surveillance data for common bacterial and fungal infections, (c) report on AMR levels and trends in the UAE, (d) strengthen local and national capacity for AMR surveillance, and (e) support AMR prevention and control strategies in the UAE. AMR surveillance data is collected through a network of 317 surveillance sites (including 84 hospitals and 233 centers/clinics), and 45 microbiology labs across all seven Emirates of the UAE.ResultsSurveillance of antimicrobial resistance has been successfully established since 2010 in the UAE. A national AMR surveillance protocol has been developed, adopting the WHO GLASS protocol. Extensive capacity-building and training activities have strengthened the local and national capacity for AMR surveillance. Between 2010 and 2021, a network of 317 surveillance sites and 45 laboratories have reported a total of 1,277,080 isolates from 662,065 non-duplicate patients to the national level. AMR data is reported annually by MOHAP through a National AMR surveillance report. National AMR data is utilized for informing the development of standard treatment guidelines at national level.ConclusionNational surveillance of antimicrobial resistance has been successfully established in the United Arab Emirates, allowing to monitor levels and trends of antimicrobial resistance for common bacterial and fungal pathogens, and detecting emerging resistance. The availability of such national AMR surveillance data allows for the first time to inform the development of national standard treatment guidelines for empiric treatment of common bacterial and fungal infections in the UAE.
Construction and evaluation of China older-adult care service smart supply chain system
Authors: Dai You-Yu , Liu Guanlong , Sun Long 
Published: November 2023

IntroductionAs the aging of the population continues to deepen, the pressure on social pensions is gradually increasing, and the issue of assistance has become a problem that must be solved. With the development of science and technology, people’s living standard is constantly improving. The older-adult care services expected by the older-adult are wider than meeting the basic daily needs of individuals. The current industry should also consider combining modern science and technology with the older-adult care service industry to serve older-adult better and enable older-adult care service providers to move towards the service needs that make people happier and healthier. This research is about constructing and evaluating China’s older-adult care services smart supply chain.MethodsBased on the research results of previous scholars, this paper divides the Sun construction of the smart supply chain of China endowment service into four aspects: policy aspect, economic aspect, social aspect, and technical aspect; the four significant elements are divided into the first-level indicators, and 16 second-level indicators are divided under the first-level indicators. The importance and satisfaction of each evaluation index were obtained by distributing questionnaires to the managers who study the supply chain and the employees who are related to the old-age service.Results and discussionAfter the reliability analysis, the importance-performance analysis (IPA) quadrant analysis chart of the evaluation index was constructed using importance-performance analysis. The index of creating a smart supply chain system for China’s old-age service is given priority, the supply chain system of China’s old-age care service is further improved, and the social security of China’s old-age service is enlarged.
Health-related quality of life and recovery capital among recovery residents taking medication for opioid use disorder in Texas
Authors: Obekpa Elizabeth O. , McCurdy Sheryl A. , Schick Vanessa , Markham Christine M. , Gallardo Kathryn R. , Wilkerson Johnny Michael 
Published: November 2023

BackgroundRecovery from opioid use disorder (OUD) includes improvements in health-related quality of life (HRQOL) and is supported by recovery capital (RC). Little is known about RC and HRQOL among recovery residents taking medication for OUD. We described HRQOL and RC and identified predictors of HRQOL.MethodsProject HOMES is an ongoing longitudinal study implemented in 14 recovery homes in Texas. This is a cross-sectional analysis of data from 358 participants’ on HRQOL (five EQ-5D-5L dimensions—mobility, self-care, usual activities, pain/discomfort, and anxiety/depression) and RC (Assessment of Recovery Capital scores) collected from April 2021 to June 2023. Statistical analyses were conducted using T-, Chi-squared, and Fisher’s exact tests.ResultsMost participants were 35 years/older (50.7%), male (58.9%), non-Hispanic White (68.4%), heterosexual (82.8%), and reported HRQOL problems, mainly anxiety/depression (78.4%) and pain/discomfort (55.7%). Participants who were 35 years/older [mean (SD) = 42.6 (7.3)] were more likely to report mobility and pain/discomfort problems than younger participants. Female participants were more likely to report pain/discomfort problems than male participants. Sexual minorities were more likely to report anxiety/depression problems than heterosexual participants. Married participants and those in committed relationships were more likely to report problems conducting self-care than single/never-married participants. Comorbid conditions were associated with mobility, pain/discomfort, and usual activities problems. Most participants reported high social (65.4%), personal (69.0%), and total (65.6%) RC. Low personal RC was associated with mobility (aOR = 0.43, CI = 0.24–0.76), self-care (aOR = 0.13, CI = 0.04–0.41), usual activities (aOR = 0.25, CI = 0.11–0.57), pain/discomfort (aOR = 0.37, CI = 0.20–0.68), and anxiety/depression (aOR = 0.33, CI = 0.15–0.73) problems. Low total RC was associated with problems conducting self-care (aOR = 0.20, CI = 0.07–0.60), usual activities (aOR = 0.43, CI = 0.22–0.83), pain/discomfort problems (aOR = 0.55, CI = 0.34–0.90), and anxiety/depression (aOR = 0.20, CI = 0.10–0.41) problems. Social RC was not associated with HRQOL.ConclusionPersonal and total RC and comorbid conditions predict HRQOL. Although the opioid crisis and the increasing prevalence of comorbidities have been described as epidemics, they are currently being addressed as separate public health issues. Our findings underscore the importance of ensuring residents are provided with interprofessional care to reduce the burden of comorbidities, which can negatively impact their OUD recovery. Their RC should be routinely assessed and enhanced to support their recovery and improve HRQOL.
Lessons learned from the Alberta Border Testing Pilot Program
Authors: Kersen Jaling , Scory Tayler D. , Akeju Oluwasefunmi , Weaver Robert G. , Barnieh Lianne , Ronksley Paul E. , Leal Jenine , Blue Dean , O’Neill Erin , Campbell David J. T. , Tonelli Marcello , Lunney Meaghan 
Published: November 2023

BackgroundDuring the Coronavirus disease (COVID-19) pandemic, countries implemented border control and quarantine measures to reduce transmission. The Alberta Border Testing Pilot Program (ABTPP) allowed international travellers entering Alberta to reduce their quarantine period following two negative COVID-19 tests. We evaluated participant experiences with the ABTPP and implementation.MethodWe used a parallel convergent mixed-methods design to explore participant experiences through electronic web-based questionnaires (n = 21,089; n = 13,839) and semi-structured telephone interviews (n = 30). We evaluated implementation through three staff focus groups (n = 11). We analysed questionnaires using descriptive statistics and analysed interviews using inductive and deductive thematic analysis. We deductively coded focus group data using the 2009 Consolidated Framework for Implementation Research (CFIR).ResultsQuestionnaires indicated minimal issues with registration forms (91.7%), symptom reports (95.5%), and COVID-19 testing (95.7%). Most respondents (95.1%) expressed willingness to participate in the ABTPP again. Interviews revealed three themes related to participant experience: program efficiency, clarity of information, and requisite effort. Focus groups identified key implementation facilitators including the single health information system, strong stakeholder partnerships, and good communication across partnerships. Barriers included program complexity, implementation timeline, and evolving external context.DiscussionParticipants reported high satisfaction with the ABTPP. Border testing programs should have high efficiency, require low effort, and use messaging that is clear and consistent. The effective implementation of border testing programs may be facilitated by strong leadership, adaptability, automated components, good communication, and simple technology. Learnings from participants and staff may help improve the implementation of border control programs for future pandemics or other emergencies.ConclusionsThe ABTTP was a novel border control measure during the COVID-19 pandemic. Our evaluation of both participant and staff experiences demonstrated high levels of traveller satisfaction and identified areas for improvement that can inform the development of future border control measures.
La didáctica y el desarrollo del pensamiento crítico en los procesos de enseñanza-aprendizaje
Authors: Mosquera-Murillo Carmen Rosa , Ospina-Orejarena Bellanire 
Published: November 2023

La investigación planteó la necesidad de valorar el nivel del pensamiento crítico y uso de la didáctica en los procesos de enseñanza-aprendizaje con los estudiantes de primaria de una institución educativa de Barrancabermeja en Colombia durante el año 2020. El estudio corresponde al enfoque cualitativo y diseño hermenéutico fenomenológico, que buscó explorar, describir y comprender situaciones teniendo en cuenta las vivencias de los participantes para descubrir elementos en común. Para el desarrollo de la investigación se trabajó con individuos que aceptaron participar en el contexto de la pandemia y que los investigadores tenían acceso, se utilizó una entrevista semiestructurada y una lista de cotejo a una muestra de 10 estudiantes y 3 docentes de la institución educativa; los ítems estaban dirigidos al logro de los dominios a los que hacía referencia las categorías indagadas. Se concluye que, el nivel de pensamiento de los estudiantes de primaria se encuentra en desarrollo, pues, aún presentan dificultades para argumentar con claridad sus ideas; de la misma forma, los docentes comprenden que en las acciones pedagógicas deben hacer desde las áreas que orientan mayor énfasis en textos contextualizados, con el fin de que los estudiantes encuentren significados ocultos que les generen mayores inquietudes y, a la vez, promuevan el desarrollo de habilidades de pensamiento crítico.
Bacteremia in Patients with Solid Organ Cancer: Insights into Epidemiology and Antibiotic Consumption
Authors: de Dios-García Begoña , Maestro Guillermo , Díaz-Pedroche Carmen , Parra Wagner , Campos Óscar , Orellana María Ángeles , Caro José Manuel , Lumbreras Carlos , Lizasoain Manuel 
Published: November 2023

Epidemiology and risk factors associated to bacterial resistance in solid organ cancer (SOC) patients has been barely described. This retrospective monocentric study analyzed clinical variables in SOC patients who developed bacteremia between 1 January 2019 and 31 December 2022. We described rates of bacterial resistance in Gram negative bacteria (80.6%): E. coli-ESBL, K. pneumoniae-ESBL, Carbapenem-Resistant K. pneumoniae and Meropenem-Resistant P. aeruginosa, as well as antibiotic consumption, and compared these rates between the medical and oncology wards. In total, we included 314 bacteremias from 253 patients. SOC patients are frequently prescribed antibiotics (40.8%), mainly fluoroquinolones. Nosocomial bacteremia accounted for 18.2% of the cases and only 14.3% of patients were neutropenic. Hepatobiliary tract was the most frequent tumor (31.5%) and source of bacteremia (38.5%). Resistant bacteria showed a decreased rate of resistance during the years studied in the oncology ward. Both K-ESBL and K-CBP resistance rates decreased (from 45.8% to 20.0%, and from 29.2% to 20.0%, respectively), as well as MRPA, which varied from a resistance rate of 28% to 16.7%. The presence of a urinary catheter (p < 0.001) and previous antibiotic prescription (p = 0.002) were risk factors for bacterial resistance. Identifying either of these risk factors could help in guiding antibiotic prescription for SOC patients.
Natural Products Induce Different Anti-Tumor Immune Responses in Murine Models of 4T1 Mammary Carcinoma and B16-F10 Melanoma
Authors: Lasso Paola , Rojas Laura , Arévalo Cindy , Urueña Claudia , Murillo Natalia , Fiorentino Susana 
Published: November 2023

Natural products obtained from Petiveria alliacea (Anamu-SC) and Caesalpinia spinosa (P2Et) have been used for cancer treatment, but the mechanisms by which they exert their antitumor activity appear to be different. In the present work, we show that the Anamu-SC extract reduces tumor growth in the 4T1 murine mammary carcinoma model but not in the B16-F10 melanoma model, unlike the standardized P2Et extract. Both extracts decreased the levels of interleukin-10 (IL-10) in the B16-F10 model, but only P2Et increased the levels of tumor necrosis factor alpha (TNFα) and interferon gamma (IFNγ). Likewise, co-treatment of P2Et and doxorubicin (Dox) significantly reduced tumor size by 70% compared to the control group, but co-treatment of Anamu-SC with Dox had no additive effect. Analysis of intratumoral immune infiltrates showed that Anamu-SC decreased CD4+ T cell frequency more than P2Et but increased CD8+ T cell frequency more significantly. Both extracts reduced intratumoral monocytic myeloid-derived suppressor-like cell (M-MDSC-LC) migration, but the effect was lost when co-treated with doxorubicin. The use of P2Et alone or in co-treatment with Anamu-SC reduced the frequency of regulatory T cells and increased the CD8+/Treg ratio. In addition, Anamu-SC reduced glucose consumption in tumor cells, but this apparently has no effect on IFNγ- and TNFα-producing T cells, although it did reduce the frequency of IL-2-producing T cells. The efficacy of these herbal preparations is increasingly clear, as is the specificity conditioned by tumor heterogeneity as well as the different chemical complexity of each preparation. Although these results contribute to the understanding of specificity and its future benefits, they also underline the fact that the development of each of these standardized extracts called polymolecular drugs must follow a rigorous path to elucidate their biological activity.
RESEARCH OF IDENTITY IN STUDENTS THAT RECEIVE SECOND HIGHER EDUCATION
Authors: Pevelko I. 
Published: November 2023

The article substantiates the need to study the problem of identity and the conditions of its formation. Theoretically, the reasons for which a person receives a second higher education, one of which is experiencing a crisis of identity.
The study of identity uses a personal approach, which is based on the laws of construction, functioning and development of personality and is a set of conceptual ideas, psychodiagnostic and developmental methods that contribute to the formation of a higher education mature identity. A structural model of subjective and crisis identity of applicants for higher education has been developed and substantiated. The content of the applicants receiving a second higher education subjective and crisis identity structural model of is that each component of the content-personal dimension makes a systematic contribution to the formation and experience of personal identity, personal and professional.It is determined that the central psychological mechanism of the reflexive process of identity is decentralization, due to which the individual finds his/her own, not imposed path of development, which is accompanied by a sense of personal and professional certainty, identity and integrity. The concept of subjective identity by substructures of personality is introduced; gained further development of ideas about the psychological conditions and means of developing the student’s identity.The results of subjective and crisis identity in applicants for second higher education and applicants receiving first higher education experimental study are presented. In particular, it was studied that only 50.01% of applicants who receive a second higher education have a personal identity and 38.8% - respectively, a professional identity. Identity status in the moratorium stage (state of identity crisis) was diagnosed in 33.33% of applicants for second higher education and 9.09% of applicants receiving first education.The structural model of subjective and crisis identity of applicants receiving a second higher education provides a basis for a productive search for preconditions and determinants as factors in overcoming the identity crisis and creating an adequate, even ideal, subjective and professional identity.
Estrategias pedagógico-productivas para la valoración del agroturismo en la educación primaria rural
Authors: Briceño Núñez Chess Emmanuel , Briceño Delgado Meggy Jacqueline , Montilla Soto Alen David 
Published: November 2023

Esta investigación se apoyó en el paradigma post positivista, tuvo un enfoque cualitativo, con un diseño de campo etnográfico, y su propósito fue indagar sobre diversas estrategias pedagógico-productivas para la valoración del agroturismo en la educación primaria rural, la muestra estuvo conformada por 5 docentes en ejercicio activo de la Escuela Rural Bolivariana La Chiquinquirá Mérida-Venezuela, quienes fueron considerados como actores contextuales o informantes clave. El estudio se llevó a cabo mediante la observación directa y participativa, y los datos fueron recabados mediante la Entrevista estructurada y en profundidad, con preguntas abiertas de amplia y flexible respuesta. Los resultados obtenidos permiten proponer cambios en los ejes de discusión y ejecución de acciones ya que se pasa de un eje productivista centrado en lo sectorial, a otras herramientas interpretativas y de gestión más compleja, en las cuales se asocia la agricultura y el resto de usos desde una estructura multifuncional.
Mutação em heterozigose de BRSK2 causando distúrbio no neurodesenvolvimento associado a displasia septo óptica plus: relato de caso
Authors: Pereira Danilo de Assis , Vieira Marta Wey , Watanabe Cyntia , Mariano Marina Helena , Marcon Nathália , Ribeiro Leonardo Louzada , Sasaki Julia Naomi Mazoni 
Published: November 2023

Introdução. A displasia septo-óptica é uma síndrome diagnosticada pela presença de: hipoplasia do nervo óptico, disgenesia da linha média e alterações hormonais da hipófise. Relato de Caso. Paciente de dois anos do sexo feminino com obesidade, baixa estatura, atraso no desenvolvimento neuropsicomotor, estereotipias em linha média, estrabismo divergente e atrofia do disco óptico. Ressonância magnética do encéfalo mostrou alterações caracterizando displasia septo-óptica plus. Realizado sequenciamento genético, identificando mutação em heterozigose no gene BRSK2 na posição chr11:1.443.106, com o diagnóstico de Distúrbio do Neurodesenvolvimento associado ao gene BRSK2 (OMIM*609236). Essa variante nunca foi descrita na literatura médica. Conclusão. Combinação do mecanismo molecular, características da região onde ela se encontra e correlação deste gene com os sintomas clínicos indicam que esta variante é provavelmente patogênica.
Implementasi Metode PXP dan OOAD dalam Pengembangan Sistem Informasi Manajemen Praktik Kerja Lapangan di SMKN 2 Balikpapan
Authors: Lengkono Brigita Marshelinne , Azhar Nur Fajri , Fiqar Tegar Palyus 
Published: November 2023

SMKN 2 Balikpapan is one of the state vocational high schools in Balikpapan that organizes Field Work Practice (PKL) programs to support student’s development in the world of work. In the current process of implementing the PKL program at SMKN 2 Balikpapan, the procedure for PKL submission is still done manually by filling out a paper form and managing it only using Microsoft Excel. SMKN-2 Balikpapan also does not yet have an information system dedicated to managing PKL data. Therefore, a PKL management information system was developed to facilitate the PKL data management process by applying the Personal Extreme Programming (PXP) method, which consists of seven stages: requirements, planning, iteration initialization, design, implementation, system testing, and retrospective. Analysis and Design (OOAD) at the planning stage in the PXP method so that the system flow can be easily understood. In this study, 73 user stories were developed through five iterations. The features developed are the PKL student data feature, the PKL application feature, the DU/DI reply confirmation feature, the placement feature, the PKL assessment feature, and so on. Testing for all features has been successful, accepted by stakeholders, and uploaded to SMKN 2 Balikpapan's hosting service. SMKN 2 Balikpapan merupakan salah satu sekolah menengah kejuruan negeri di Balikpapan yang menyelenggarakan program Praktik Kerja Lapangan (PKL) untuk mendukung perkembangan siswa dalam dunia kerja. Pada proses pelaksanaan program PKL di SMKN 2 Balikpapan saat ini, prosedur pengajuan PKL masih dilakukan secara manual dengan mengisi sebuah formulir berupa kertas dan pengelolaannya hanya dengan menggunakan Microsoft Excel. SMKN 2 Balikpapan juga belum memiliki sistem informasi yang dikhususkan untuk mengelola data PKL. Oleh sebab itu, sistem informasi manajemen PKL dikembangkan agar memudahkan proses pengelolaan data PKL dengan menerapkan metode PXP (Personal Extreme Programming) yang terdiri atas 7 tahap yaitu requirements, planning, iteration initialization, design, implementation, system testing, dan retrospective, serta menerapkan metode OOAD (Object Oriented Analysis and Design) pada tahap planning dalam metode PXP sehingga alur sistem dapat dipahami dengan mudah. Pada penelitian ini, dikembangkan 73 user story yang melalui 5 iterasi. Fitur yang dikembangkan yaitu fitur data siswa PKL, fitur pengajuan PKL, fitur konfirmasi balasan DU/DI, fitur penempatan, fitur penilaian PKL, dan lain sebagainya. Pengujian untuk keseluruhan fitur telah berhasil dan diterima oleh stakeholder, serta telah diunggah pada layanan hosting milik SMKN 2 Balikpapan.