bluuebunny/crossref_metadata_2025_split huggingface dataset:
The protective role of resveratrol against high glucose‐induced oxidative stress and apoptosis in HepG2 cells
Authors: Tshivhase Abegail Mukhethwa , Matsha Tandi , Raghubeer Shanel 
Published: February 2024

AbstractHigh glucose concentrations result in oxidative stress, leading to damage of cellular constituents like DNA, proteins, and lipids, ultimately resulting in apoptosis. Resveratrol, a polyphenol phytoalexin, has been studied for its potential therapeutic effects on diabetes. This study investigated the influence of high glucose (HG) on HepG2 cells and assessed resveratrol's effect on high‐glucose‐induced oxidative stress and apoptosis. HepG2 cells were cultured for 48 and 72 h with high glucose (40 mM), low resveratrol (25 μM), high resveratrol (50 μM), high glucose + low resveratrol, and high glucose + high resveratrol. After exposure, oxidative and apoptosis‐related gene expression was evaluated using quantitative polymerase chain reaction (qPCR), and lactate dehydrogenase (LDH) release was measured using the supernatant. In HepG2 cells cultured with high glucose, all antioxidant enzymes (SOD, superoxide dismutase; GPx1, glutathione peroxidase 1; CAT, catalase; Nrf2, nuclear factor erythroid 2–related factor 2; and NQO1, NAD(P)H quinone oxidoreductase 1) were significantly reduced; however, when HepG2 cells were cultured with resveratrol (25 and 50 μM) and high glucose, the expression levels of all antioxidant enzymes were increased. The anti‐apoptotic gene (B‐cell lymphoma 2; Bcl2) and the DNA repair gene (Oxoguanine glycosylase‐1, OGG1) were significantly decreased following high glucose exposure to HepG2 cells. Surprisingly, the expression levels of Bcl2 and OGG1 were notably elevated after resveratrol treatment. Furthermore, high glucose levels increased the LHD release in HepG2 cells, whereas resveratrol treatment reduced the LDH release. Our results demonstrate that resveratrol provides protection against oxidative stress and apoptosis induced by high glucose in HepG2 cells. Hence, resveratrol shows potential as an effective approach to address the impaired antioxidant response resulting from elevated glucose levels commonly observed in diabetes and metabolic disorders.
Evaluation of factors related to organic food consumption and orthorexia nervosa tendencies
Authors: Bozkurt Osman , Kocaadam‐Bozkurt Betul 
Published: February 2024

AbstractThe relationship between organic food consumption, awareness of reducing ecological footprint, and orthorexia nervosa (ON) tendencies has yet to be explored in detail. This study aimed to determine factors related to organic food consumption and ON tendencies in young adults. Also, the relationship between organic food consumption, awareness of reducing ecological footprint, and ON tendencies was investigated. This study was conducted with 887 young adults (58.4% female, 41.6% male, aged 18–25 years, mean age 20.8 ± 2.55 years). Study data were obtained with a web‐based questionnaire. The questionnaire included socio‐demographic characteristics, anthropometric measurements, the Organic Food Consumption Scale (OFC), ORTO‐11, and the Awareness Scale for Reducing Ecological Footprint (ASREF). While 17.2% were overweight or obese, 74.9% had a normal body weight. There were no differences by sex in terms of ORTO‐11, OFC, and ASREF total scores (p > .05). Significant positive correlations were found between ASREF and OFC (p < .001), while negative correlations were found for ORTO‐11 and OFC (p < .001). A higher ASREF and increased ON tendencies predicted increased organic food consumption (p < .05). Furthermore, higher organic food consumption behaviors and awareness of reducing ecological footprint predicted increased ON tendencies (p < .05). Findings from this study will contribute to a deeper understanding of the factors associated with organic food consumption and ON tendencies among individuals. By shedding light on the interplay between ecological awareness, organic food consumption, and orthorexic tendencies, policymakers and health professionals can develop targeted interventions to promote sustainable and healthy food consumption.
Enhancing yield and oil content in oilseed rape hybrids: Insights from line × tester and SIIG approaches
Authors: Hashemi Parastoo Sadat , Mohammadi Abdollah , Alizadeh Bahram , Mostafavi Khodadad , Amiri Oghan Hassan 
Published: February 2024

AbstractBackgroundThe production of high‐oil‐yielding hybrid varieties is a primary objective in oilseed rape (Brassica napus L.) breeding programs. Biometric genetic experiments such as line × tester provide valuable insights into the genetic structure of traits associated with high oil yield.MethodsIn this study, 21 winter hybrids of oilseed rape were evaluated, which were generated by crossing three restorers with seven CMS lines. The experiment was conducted using a line × tester experiment based on a completely randomized block design. Phenological, agronomic, yield, and oil yield components were assessed in this study. The ideal genotype selection index (SIIG) methodology was also employed to identify superior hybrids based on all studied traits simultaneously.ResultsSignificant differences were observed between the obtained hybrids and the check cultivars. Heritability analysis revealed that phenological traits were primarily controlled by additive effects, while agronomic and qualitative traits were mainly influenced by non‐additive gene effects. Both broad‐sense and narrow‐sense heritability exhibited a wide range, underscoring the importance of genetic variance. Notably, the hybrids T1 × L5, T1 × L6, and T3 × L1 showed significant specific combining ability values of 394.74, 541.73, and 1236.79, respectively, making them the top specific combinations for increasing seed yield. Based on the SIIG index, hybrids T3 × L1, T1 × L5, T1 × L3, and T2 × L3 emerged as high‐oil‐yielding hybrids with desirable agronomic traits.ConclusionsThe identified superior hybrids by line × tester and SIIG approaches hold promise for the development of high‐yielding oilseed rape cultivars with desirable agronomic traits in oilseed rape breeding programs.
A narrative review of the effects of vitamin D3 on orthodontic tooth movement: Focus on molecular and cellular mechanisms
Authors: Zamanian Mohammad Yasin , Golmohammadi Maryam , Vadiyan Filipp V. , Almulla Ausama A. , Vadiyan Diana E. , Morozova Natalia S. , Alkadir Ola Kamal A. , Kareem Anaheed Hussein , Alijani Mojtaba 
Published: February 2024

AbstractOrthodontic tooth movement (OTM) is a critical process in dental alignment, driven by the application of calibrated orthodontic forces. This study delves into the intricate molecular and cellular mechanisms by which vitamin D3 influences OTM. Vitamin D3 is identified as a critical regulator in bone metabolism, enhancing osteoblast activity and bone formation while also modulating osteoclast quantity and RANKL expression, essential for the remodeling of the alveolar bone. The precise mechanisms through which vitamin D3 facilitates these processes are explored, highlighting its potential in accelerating bone remodeling and, consequently, tooth alignment. This comprehensive review underscores vitamin D3's anabolic impact on bone metabolism and its pivotal role in the synthesis and mineralization processes governed by osteoblasts. The findings illuminate vitamin D3's promise in augmenting orthodontic therapy, suggesting its utility in improving treatment efficiency and reducing duration. However, the need for further research into the optimal application of vitamin D3 in orthodontics is emphasized, particularly concerning dosage, timing, and delivery methods.
Emotional inhibition mediates the relationship between maternal postpartum security and pregnancy distress in China: A cross‐sectional study
Authors: Wang Hengxu , Zheng Mingxiang , Li ChaoFeng , Wu Ying , Fan Min , Liu Lihua 
Published: February 2024

AbstractObjectivePregnancy and childbirth bring not only joy but also a concomitant sense of insecurity, which may adversely affect health, role adaptation, and relationships. This study aimed to explore the risk factors for postpartum mothers' sense of security.MethodsThis cross‐sectional study used questionnaires on Parents' Postnatal Sense of Security, Tilburg Pregnancy Distress Scale, and the Emotional Inhibition Scale. Structural equation modeling was used to calculate the mediating effect.ResultsThe mean postnatal maternal security value was 44.77 ± 9.02. Multiple regression analyses revealed that several factors, including companionship of the partner during pregnancy, number of prenatal visits accompanied by the partner, complications during pregnancy, pregnancy distress, and emotional inhibition, independently predicted maternal security. Moreover, our structural equation model revealed that emotional inhibition significantly influenced maternal postpartum security directly (β = −0.30, P < 0.001). In addition, pregnancy distress affected maternal security directly (β = −0.45, P < 0.001) and indirectly (β = −0.129, P < 0.001) through emotional inhibition.ConclusionThis study indicated a lower level of postpartum maternal sense of security. Emotional inhibition partially mediates the relationship between postpartum maternal sense of security and pregnancy distress. Therefore, health care professionals providing guidance to pregnant and postpartum women on proper emotional regulation and early identification of pregnancy distress may be more effective in enhancing their postpartum sense of security.
“Oh my god, I did that!”: Proud writing moments as a key ingredient for supportive and individualized writing instruction
Authors: Fields Susan S. , Dobbs Christina L. 
Published: February 2024

AbstractThis discussion article presents practices for designing more supportive and individualized writing tasks for adolescent and young adult students. The practices emerged from a synthesis of findings from a prior study in which we asked 79 undergraduates to talk about moments from their writing histories that made them feel proud of their writing.
Integrating clinical pharmacists into transitions of care: A qualitative study of barriers and facilitators among federally qualified health centers
Authors: Weideman Ben C. D. , White Katie M. , Farley Joel F. , Sorge Lindsay A. , Pradeep Swetha , Cannon Athena , Tran Kim , Pestka Deborah L. 
Published: February 2024

AbstractBackgroundComprehensive medication management (CMM) is a service provided by clinical pharmacists. CMM aims to optimize pharmacotherapy outcomes by ensuring patients' medications are indicated, effective, safe, and patients are able to adhere to the prescribed medication regimen and take the medications as intended. The goal of CMM is to optimize patients' medications to ensure they are meeting their medication and health‐related goals.ObjectiveThe objective of this project is to evaluate facilitators and barriers to integrating CMM during transitions of care (ToC) at Federally Qualified Health Centers (FQHCs).DesignSemistructured qualitative interviews were conducted with 22 key informants identified through purposive sampling at three FQHCs. Interviews were coded and analyzed deductively using a modified Consolidated Framework for Implementation Research (CFIR) adapted for ToC.Key ResultsThirty‐nine codes were identified across all CFIR constructs, including the addition of a new construct, “Patient characteristics.” Major facilitators included the perceived advantage and feasibility of the intervention, standardization of ToC processes, and organizational buy‐in. Major barriers included health information technology system limitations, communication barriers with discharge facilities, technical and staffing challenges in applying criteria to identify patients for CMM, and low patient throughput.ConclusionsIdentifying early‐stage barriers and facilitators are key to maximize facilitators and address barriers to support successful implementation. The findings of this work are being used to guide project adaptations to better integrate CMM into the ToC processes.
l‐Methionine potentiates anticancer activity of Sorafenib by epigenetically altering DUSP3/ERK pathway in hepatocellular carcinoma
Authors: Pal Swagata , Kabeer Shaheen Wasil , Sharma Shivam , Tikoo Kulbhushan 
Published: February 2024

AbstractHepatocellular carcinoma (HCC) is the third most common cancer‐related cause of death worldwide. Although Sorafenib is the standard systemic therapy for treating HCC, but it develops resistance very quickly, leading to poor prognosis. The current study was planned to explore the effect of l‐methionine on the anticancer activity of Sorafenib in HCC. Ten millimolar of l‐methionine treatment significantly reduced the IC50 of Sorafenib from 5.513 ± 0.171 to 0.8095 ± 0.0465 µM in HepG2 cell line. It also resulted in concomitant increase in oxidative stress and deactivation of ERK/AMPK/AKT pathway. Additionally, it also resulted in the increased expression of dual specificity phosphatase 3 (DUSP3). In a rat model of sorafenib‐resistant HCC induced by diethylnitrosamine (DEN) (100 mg/L/day) and Sorafenib (10 mg/kg), l‐methionine (300 and 500 mg/kg/day) supplementation overcame the drug resistance, as indicated by the reduced formation of surface tumor nodules, prevention of cellular hypertrophy, hyperplasia and inflammation, and improved animal survival. Furthermore, l‐methionine in combination with Sorafenib also inhibited AMPK/AKT and ERK pathway. At chromatin level, l‐methionine supplementation prevented global methylation of H3K27me3, an inactivation mark, and demethylation of H3K36me2, an activation mark. Interestingly, our findings suggest that inhibition of the ERK pathway via increased activity of DUSP3 is epigenetically regulated. Besides, chromatin immunoprecipitation data exhibited augmented H3K36me2 (an activation mark) levels on the DUSP3 promoter region. To the best of our knowledge, we are the first to report that l‐methionine supplementation improves the chemosensitivity in Sorafenib‐resistant HCC via modulating the epigenetic landscape and can be a potential therapeutic strategy.
Differential relations between breathing retraining, in vivo exposure, and imaginal exposure homework completion and treatment outcomes in veterans receiving prolonged exposure for PTSD
Authors: Gros Daniel F. , Pavlacic Jeffrey M. , Argyriou Evangelia , Acierno Ron , Hernandez‐Tejada Melba A. 
Published: February 2024

AbstractObjectivesLimited research exists that outlines the predictive relevance of the treatment components of prolonged exposure (PE) for post‐traumatic stress disorder (PTSD) on PTSD and depression symptom outcomes. The goal of the present study was to investigate relations between participant completion of breathing retraining, in vivo exposure, and imaginal exposure exercises and symptom outcomes.MethodsA total of 58 participants completed a trial of PE as part of a larger trial on peer involvement and treatment adherence. Diagnostic and self‐report measures were completed throughout treatment. Participants also recorded weekly completion of breathing retraining, in vivo exposure, and imaginal exposure exercises. Pearson correlations and hierarchical regression analyses were used to investigate relations between average weekly treatment component completion and treatment outcomes, controlling for relevant variables.ResultsAlthough breathing retraining and in vivo exposures were associated with PTSD outcomes in the correlational findings, use of breathing retraining, in vivo exposures, and imaginal exposures were not reliably associated with PTSD symptom outcomes when controlling for other variables in the regression analysis. However, when investigating changes in comorbid symptoms of depression, greater use of breathing retraining was associated with decreased symptoms of depression at posttreatment.ConclusionsPresent findings demonstrate the differential relations between participation in various PE treatment components and posttreatment symptom outcomes. The importance of breathing retraining in addressing comorbid depressive symptoms is discussed, with emphasis on potentially increasing relaxation and positive activities more broadly to encourage further treatment benefits.
Investigating the network structure and causal relationships among bridge symptoms of comorbid depression and anxiety: A Bayesian network analysis
Authors: Wang Yu , Li Zhongquan , Cao Xing 
Published: February 2024

AbstractBackgroundThe network analysis method emphasizes the interaction between individual symptoms to identify shared or bridging symptoms between depression and anxiety to understand comorbidity. However, the network analysis and community detection approach have limitations in identifying causal relationships among symptoms. This study aims to address this gap by applying Bayesian network (BN) analysis to investigate potential causal relationships.MethodData were collected from a sample of newly enrolled college students. The network structure of depression and anxiety was estimated using the Patient Health Questionnaire‐9 (PHQ‐9) and the Generalized Anxiety Disorder (GAD‐7) Scale measures, respectively. Shared symptoms between depression and anxiety were identified through network analysis and clique percolation (CP) method. The causal relationships among symptoms were estimated using BN.ResultsThe strongest bridge symptoms, as indicated by bridge strength, include sad mood (PHQ2), motor (PHQ8), suicide (PHQ9), restlessness (GAD5), and irritability (GAD6). These bridge symptoms formed a distinct community using the CP algorithm. Sad mood (PHQ2) played an activating role, influencing other symptoms. Meanwhile, restlessness (GAD5) played a mediating role with reciprocal influences on both anxiety and depression symptoms. Motor (PHQ8), suicide (PHQ9), and irritability (GAD6) assumed recipient positions.ConclusionBN analysis presents a valuable approach for investigating the complex interplay between symptoms in the context of comorbid depression and anxiety. It identifies two activating symptoms (i.e., sadness and worry), which serve to underscore the fundamental differences between these two disorders. Additionally, psychomotor symptoms and suicidal ideations are recognized as recipient roles, being influenced by other symptoms within the network.
Bilateral trade between China and ASEAN countries before and during COVID‐19 using a comparative analysis
Authors: Ma Liwen , Ali Mohsin 
Published: February 2024

AbstractASEAN organizations play a vital role in sustaining bilateral trade between China and ASEAN countries. However, the COVID‐19 pandemic has introduced disruptions to global bilateral trade. Therefore, research should investigate the impact of ASEAN organizations on the trade between China and ASEAN nations, particularly during the pandemic. This study aims to address the effectiveness of ASEAN organizations in managing bilateral trade during the pandemic and gauging their influence. The study's sample includes nine ASEAN countries, and the data span from 2016 to 2021. The analysis uses the difference‐in‐differences model, with the parallel trend test verifying the differences between investigated variables. The results demonstrate that the influence of the ASEAN organization is significant on trade activities between China and the ASEAN member countries, positively impacting bilateral trade during the COVID‐19 period. These findings not only contribute to our understanding of bilateral trade during a special period but also offer insights for enhancing the efficacy of the ASEAN organization and governments to promote bilateral trade.
Biophysical and structural characterization of tetramethrin serum protein complex and its toxicological implications
Authors: Singh Pratik , Gopi Priyanka , Rani Majji Sai Sudha , Singh Shweta , Pandya Prateek 
Published: February 2024

AbstractTetramethrin (TMT) is a commonly used insecticide and has a carcinogenic and neurodegenerative effect on humans. The binding mechanism and toxicological implications of TMT to human serum albumin (HSA) were examined in this study employing a combination of biophysical and computational methods indicating moderate binding affinity and potential hepato and renal toxicity. Fluorescence quenching experiments showed that TMT binds to HSA with a moderate affinity, and the binding process was spontaneous and predominantly enthalpy‐driven. Circular dichroism spectroscopy revealed that TMT binding did not induce any significant conformational changes in HSA, resulting in no changes in its alpha‐helix content. The binding site and modalities of TMT interactions with HSA as computed by molecular docking and molecular dynamics simulations revealed that it binds to Sudlow site II of HSA via hydrophobic interactions through its dimethylcyclopropane carboxylate methyl propanyl group. The structural dynamics of TMT induce proper fit into the binding site creating increased and stabilizing interactions. Additionally, molecular mechanics–Poisson Boltzmann surface area calculations also indicated that non‐polar and van der Waals were found to be the major contributors to the high binding free energy of the complex. Quantum mechanics (QM) revealed the conformational energies of the binding confirmation and the degree of deviation from the global minimum energy conformation of TMT. The results of this study provide a comprehensive understanding of the binding mechanism of TMT with HSA, which is important for evaluating the toxicity of this insecticide in humans.
A scoping review of human skeletal kinematics research using biplane radiography
Authors: Setliff Joshua C. , Anderst William J. 
Published: February 2024

AbstractBiplane radiography has emerged as the gold standard for accurately measuring in vivo skeletal kinematics during physiological loading. The purpose of this scoping review was to map the extent, range, and nature of biplane radiography research on humans from 2004 through 2022. A literature search was performed using the terms biplane radiography, dual fluoroscopy, dynamic stereo X‐ray, and biplane videoradiography. All articles referenced in included publications were also assessed for inclusion. A secondary search was then performed using the names of the most frequently appearing principal investigators among included papers. A total of 379 manuscripts were identified and included. The first studies published in 2004 focused on the native knee, followed by studies of the ankle joint complex in 2006, the shoulder in 2007, and the spine in 2008. Nearly half (180, 47.5%) of all manuscripts investigated knee kinematics. The average number of publications increased from 21.6 per year from 2012 to 2017 to 34.6 per year from 2017 to 2022. The average number of participants per study was 16, with a range from 1 to 101. A total of 90.2% of studies featured cohorts of 30 or less. The most prolific research groups for each joint were: Mass General Hospital (lumbar spine and knee), Henry Ford Hospital (shoulder), the University of Utah (ankle and hip), The University of Pittsburgh (cervical spine), and Brown University (hand/wrist/elbow). Future advancements in biplane radiography research are dependent upon increased availability of these imaging systems, standardization of data collection protocols, and the development of automated approaches to expedite data processing.