bluuebunny/crossref_metadata_2025_split huggingface dataset:
Person‐centred integrated care for people living with Parkinson's, Huntington's and Multiple Sclerosis: A systematic review
Authors: Bartolomeu Pires Sandra , Kunkel Dorit , Kipps Christopher , Goodwin Nick , Portillo Mari C. 
Published: December 2023

AbstractIntroductionPeople living with long‐term neurological conditions (LTNCs) have complex needs that demand intensive care coordination between sectors. This review aimed to establish if integrated care improves outcomes for people, and what characterises successful interventions.MethodsA systematic review of the literature was undertaken evaluating multisectoral integrated care interventions in people living with Parkinson's disease (PD), Multiple Sclerosis (MS) and Huntington's disease (HD). Strength of evidence was rated for the different outcomes.ResultsA total of 15 articles were included, reporting on 2095 patients and caregivers, finding that integrated care can improve people's access to resources and reduce patients' depression. UK studies indicated improvements in patients' quality of life, although the international literature was inconclusive. Few programmes considered caregivers' outcomes, reporting no difference or even worsening in depression, burden and quality of life. Overall, the evidence showed a mismatch between people's needs and outcomes measured, with significant outcomes (e.g., self‐management, continuity of care, care experience) lacking. Successful programmes were characterised by expert knowledge, multisectoral care coordination, care continuity and a person‐centred approach.ConclusionsThe impact of integrated care programmes on people living with LTNCs is limited and inconclusive. For a more person‐centred approach, future studies need to assess integrated care from a service‐user perspective.Patient and Public ContributionThirty people living with LTNCs were involved in this review, through defining research questions, validating the importance of the project, and increasing the researchers' understanding on what matters to service users. A patient and public involvement subgroup of representatives with lived experience on PD, MS and HD identified the need for more person‐centred integrated care, with specific concerns over care fragmentation, care duplication and care continuity. This was key to data analysis and formulating the characteristics of successful and unsuccessful integrated care programmes from the perspective of service users. The discrepancy between service users' needs and the outcomes assessed in the literature point to user‐driven research as the solution to address what matters to patients and caregivers.
An international consensus study to identify “what” outcomes should be included in a core outcome set for endodontic treatments (COSET) for utilization in clinical practice and research
Authors: El Karim Ikhlas , Duncan Henry Fergus , Cushley Siobhan , Nagendrababu Venkateshbabu , Kirkevang Lise‐Lotte , Kruse Casper Lemvig , Chong Bun San , Shah Pratik Kamalkant , Lappin Mark , Lundy Fionnuala T. , Clarke Mike ,   Consensus workshop participants
Published: December 2023

AbstractBackgroundDevelopment of a standardized set of topic‐specific outcomes known as a Core Outcome Set (COS) is important to address issues of heterogeneity in reporting research findings in order to streamline evidence synthesis and clinical decision making.AimThe aim of the current international consensus study is to identify “what” outcomes to include in the Core Outcome Set for Endodontic Treatments (COSET). Outcomes of various endodontic treatments (non‐surgical root canal treatment, surgical endodontics, vital pulp treatment and revitalization procedures) performed on permanent teeth were considered.MethodsA standard validated methodology for COS development and reporting was adopted. The process involved identification of existing outcomes through four published scoping reviews. This enabled creation of a list of outcomes to be prioritized via semi‐structured patient interviews, e‐Delphi process and a consensus meeting with a range of relevant global stakeholders. Outcomes were prioritized using a 1–9 Likert scale, with outcomes rated 7–9 considered critical, 4–6 are important and 1–3 are less important. Outcomes rated 7–9 by ≥70% and 1–3 by <15% of participants were considered to achieve consensus for inclusion in the COS. The outcomes that did not achieve consensus in the first round were considered for further prioritization in the second Delphi round and consensus meeting. Final decisions about the outcomes to include in COSET were made by voting during the consensus panel meeting using the Zoom Poll function.ResultsA total of 95 participants including patients contributed to the COS development process. The consensus panel recommended, with strong consensus, eight outcomes shared across all treatment modalities for inclusion in COSET: pain; signs of infection (swelling, sinus tract); further intervention/exacerbation; tenderness to percussion/palpation; radiographic evidence of disease progression/healing; function; tooth survival; and patient satisfaction. Additional treatment specific outcomes were also recommended.DiscussionMany of the outcomes included in COSET are patient reported. All should be included in future outcomes studies.ConclusionCOSET identified outcomes that are important for patients and clinicians and validated these using a rigorous methodology. Further work is ongoing to determine “how” and “when” these outcomes should be measured.
Microstructure and physicochemical properties: effects of different pretreatment combined with dual‐frequency ultrasound on quality of large yellow croaker (Pseudosciaena crocea) during cold storage
Authors: Lan Weiqing , Yan Peiling , Zhao Xinyu , Zhu Shengyun , Pu Tianting , Xie Jing 
Published: December 2023

SummaryThe quality changes of cold‐stored (4 °C) large yellow croaker (Pseudosciaena crocea) were studied by using stable chlorine dioxide combined with dual‐frequency ultrasound assisted‐slightly acidic electrolysed water (CUSS). The results of microbial indicators demonstrated that CUSS treatment inhibited microbial growth. Moreover, CUSS treatment had lower values of pH, total volatile basic nitrogen (TVB‐N) and thiobarbituric acid (TBA), and higher immobilised water content. CUSS treatment also inhibited the degradation of inosine monophosphate, suppressed the accumulation of hypoxanthine riboside and hypoxanthine. Through the results of texture profile analysis (TPA), protein degradation, and scanning electron microscopy (SEM), CUSS treatment could effectively protect the protein structure and maintain good texture characteristics of large yellow croaker. According to microbial indexes, K‐value, and sensory analysis, compared with dual‐frequency ultrasound treatment, CUSS treatment could prolong the shelf‐life of large yellow croaker for another six days. Therefore, CUSS treatment is a potential solution to preserve large yellow croaker, improving its protein characteristics.
Comparison of the stability of glycoprotein acetyls and high sensitivity C‐reactive protein as markers of chronic inflammation
Authors: Crick Daisy C. P. , Khandaker Golam M. , Halligan Sarah L. , Burgner David , Mansell Toby , Fraser Abigail 
Published: December 2023

AbstractIt has been suggested that glycoprotein acetyls (GlycA) better reflects chronic inflammation than high sensitivity C‐reactive protein (hsCRP), but paediatric/life‐course data are sparse. Using data from the Avon Longitudinal Study of Parents and Children (ALSPAC) and UK Biobank, we compared short‐ (over weeks) and long‐term (over years) correlations of GlycA and hsCRP, cross‐sectional correlations between GlycA and hsCRP, and associations of pro‐inflammatory risk factors with GlycA and hsCRP across the life‐course. GlycA showed high short‐term (weeks) stability at 15 years (r = 0.75; 95% CI = 0.56, 0.94), 18 years (r = 0.74; 0.64, 0.85), 24 years (r = 0.74; 0.51, 0.98) and 48 years (r = 0.82 0.76, 0.86) and this was comparable to the short‐term stability of hsCRP at 24 years. GlycA stability was moderate over the long‐term, for example between 15 and 18 years r = 0.52; 0.47, 0.56 and between 15 and 24 years r = 0.37; 0.31, 0.44. These were larger than equivalent correlations of hsCRP. GlycA and concurrently measured hsCRP were moderately correlated at all ages, for example at 15 years (r = 0.44; 0.40, 0.48) and at 18 years (r = 0.55; 0.51, 0.59). We found similar associations of known proinflammatory factors and inflammatory diseases with GlycA and hsCRP. For example, BMI was positively associated with GlycA (mean difference in GlycA per standard deviation change in BMI = 0.08; 95% CI = 0.07, 0.10) and hsCRP (0.10; 0.08, 0.11). This study showed that GlycA has greater long‐term stability than hsCRP, however associations of proinflammatory factors with GlycA and hsCRP were broadly similar.
Information intensity and pricing of systematic earnings announcement risk
Authors: Chen Jingjing , Chen Linda H. , Jiang George J. 
Published: December 2023

AbstractEarnings announcement (EA) poses a non‐diversifiable risk to investors. This study examines whether investors demand higher returns for stocks with high systematic EA risk. We find evidence that systematic EA risk is priced, however, the premium is realized only during periods with intensified cash‐flow news. Specifically, we construct an ex‐ante measure of expected information intensity (EII) and find that in the subsample of high‐EII firms, those with high systematic EA risk earn significantly higher future returns. Controlling for known risk factors, stocks with high systematic EA risk outperform those with low systematic EA risk by 0.43% in monthly Fama–French five‐factor alpha. We also confirm the well‐documented announcement premium, i.e., high‐EII firms outperform low‐EII firms and show that the EA risk premium is distinct from the announcement premium. To exploit both premiums, a feasible strategy of long stocks with both high‐EII and high systematic EA risk and short stocks with low‐EII yields monthly 0.81% five‐factor alpha.
A surfactant‐based dressing can reduce the appearance of Pseudomonas aeruginosa pigments and uncover the dermal extracellular matrix in an ex vivo porcine skin wound model
Authors: Seo Soojung , Yang Qingping , Jeong Sunyoung , Della Porta Alessandra , Kapoor Harris , Gibson Daniel J. 
Published: December 2023

AbstractFrom previous studies, we have shown that viable colony forming units of bacteria and bacterial biofilms are reduced after sequential treatment with a surfactant‐based dressing. Here, we sought to test the impact on visible bacterial pigments and the ultrastructural impact following the sequential treatment of the same surfactant‐based dressing. Mature Pseudomonas aeruginosa biofilms were grown on ex vivo porcine skin explants, and an imaging‐based analysis was used to compare the skin with and without a concentrated surfactant. In explants naturally tinted by bacterial chromophores, wiping alone had no effect, while the use of a surfactant‐based dressing reduced coloration. Similarly, daily wiping led to increased immunohistochemical staining for P. aeruginosa antigens, but not in the surfactant group. Confocal immunofluorescent imaging revealed limited bacterial penetration and coating of the dermis and loose pieces of sloughing material. Ultrastructural analysis confirmed that the biofilms were masking the extracellular matrix (ECM), but the surfactant could remove them, re‐exposing the ECM. The masking of the ECM may provide another non‐inflammatory explanation for delayed healing, as the ECM is no longer accessible for wound cell locomotion. The use of a poloxamer‐based surfactant appears to be an effective way to remove bacterial chromophores and the biofilm coating the ECM fibres.
The effect of dexmedetomidine on postoperative wound healing in neurosurgical patients: A meta‐analysis
Authors: Zhu Congying , Cao Donghang , Chen Lingyang , Zheng Xuhang , Lin Danjiang 
Published: December 2023

AbstractThis meta‐analysis investigates the effect of dexmedetomidine on postoperative wound healing in neurosurgical patients. A thorough literature search resulted in the selection of seven studies from an initial pool of 1546 records. The analysis focused on wound healing outcomes, evaluated by the Redness, Oedema, Ecchymosis, Discharge, Approximation (REEDA) scale and the Manchester Scar Scale (MSS). Results indicated significant improvements in the dexmedetomidine group: the REEDA scale scores at day seven post‐surgery showed a Standardized Mean Difference group (SMD = −16.18, 95% CI: [−22.30, −10.06], p < 0.01), and the MSS scores at 3 months post‐operation demonstrated an (SMD = −8.95, 95% CI: [−14.27, −3.62], p < 0.01). These findings suggest that dexmedetomidine may enhance wound healing and reduce scar formation in neurosurgical patients. Bias assessment indicated a low risk of bias across the studies.
Risk factors for surgical site infection after percutaneous endoscopic lumbar discectomy
Authors: Xiao Bo , Chen Tian‐yi , Zhao Qiang , Zhao Ming , Yang Guo‐qi , Zhong Xiao‐hui , Xu Yin‐zhi 
Published: December 2023

AbstractThe objective of this study was to investigate the risk factors associated with surgical site infection (SSI) after percutaneous endoscopic lumbar discectomy (PELD) in patients with lumbar disc herniation (LDH). A retrospective analysis was performed on a cohort of 335 patients who underwent PELD between January 2016 and January 2023. Data were derived from the Hospital Information System (HIS), and a comprehensive statistical assessment was performed using IBM SPSS Statistics version 25.0. Both univariate and multivariate logistic regression analyses assessed a range of risk determinants, such as age, body mass index (BMI), comorbidities, laboratory test parameters and surgery‐related variables. The incidence of SSI after PELD was 2.7% (9/335). Univariate analysis highlighted BMI, diabetes mellitus, long‐term corticosteroid consumption, surgical time and cerebrospinal fluid leakage as significant predictors of SSI. Multivariate logistic regression identified BMI, diabetes mellitus, long‐term corticosteroid consumption, surgical time and cerebrospinal fluid leakage as significant risk factors for SSI after PELD. High BMI, diabetes mellitus, long‐term corticosteroid consumption, long surgical time and postoperative cerebrospinal fluid leakage are predisposing factors for SSI in patients undergoing PELD. Precise interventions focused on such risk components, including careful preoperative assessment and strategic postoperative care, are essential to reduce the incidence of SSI and improve surgical efficacy.
Do climate risk disclosures matter to financial analysts?
Authors: Ben‐Amar Walid , Herrera Diana Castro , Martinez Isabelle 
Published: December 2023

AbstractThis paper examines whether and when corporate disclosures about a firm's exposure to climate risks matter to financial analysts. More specifically, we investigate the association between climate risk disclosure (CRD) and two properties of financial analysts’ earnings forecasts (accuracy and dispersion). We predict that climate risk financial materiality at the industry level moderates this association. Using a sample of 2184 US nonfinancial firm‐year observations over the period 2010–2016, we show that CRD is associated with higher forecast precision and lower dispersion only when climate risks are perceived by investors as being financially material at the industry level. We also find that while corporate disclosures about transition risks are not associated with financial analyst forecast properties, 10‐K disclosures about climate‐related material physical risks reduce analyst forecast error and dispersion.
Comparative effects of fixed‐dose mitiglinide/voglibose combination and glimepiride on vascular endothelial function and glycemic variability in patients with type 2 diabetes: A randomized controlled trial
Authors: Tanaka Kenichi , Okada Yosuke , Umezu Saeko , Hashimoto Ryoma , Tomoyose Yukiko , Tateyama Rina , Hori Yuri , Saito Momo , Tokutsu Akemi , Sonoda Satomi , Uemura Fumi , Kurozumi Akira , Tanaka Yoshiya 
Published: December 2023

ABSTRACTIntroductionThe aim of this study was to compare the effects of mitiglinide/voglibose with those of glimepiride on glycemic variability and vascular endothelial function in patients with type 2 diabetes.Materials and MethodsIt was a multicenter, open‐label, randomized, crossover study. Hospitalized patients received either mitiglinide/voglibose (three times daily administration of 10 mg mitiglinide and 0.2 mg voglibose) or glimepiride (once‐daily 2 mg) in random order, each for 5 days. The reactive hyperemia index (RHI) and the mean amplitude of glycemic excursions (MAGE) were measured as co‐primary endpoints using reactive hyperemia peripheral arterial tonometry and continuous glucose monitoring.ResultsThe analysis included 30 patients (15 in each group). The RHI was 1.670 ± 0.369 during treatment with mitiglinide/voglibose and 1.716 ± 0.492 during treatment with glimepiride, with no significant difference between the two. MAGE was significantly lower in the mitiglinide/voglibose group (47.6 ± 18.5 mg/dL) than in the glimepiride group (100.6 ± 32.2 mg/dL). Although the mean blood glucose levels over the entire 24 h period were comparable between the two groups, the use of mitiglinide/voglibose was associated with a lower standard deviation of mean glucose, coefficient of variation, and mean postprandial glucose excursion compared with glimepiride. The time below range (<70 mg/dL) and the time above range (>180, >200, and 250 mg/dL) were lower in the mitiglinide/voglibose group, while the time in range (70–180 mg/dL) was higher.ConclusionsIn our short‐duration randomized crossover study, although not impacting vascular endothelial function, mitiglinide/voglibose demonstrated potential benefits in reducing glycemic variability, postprandial hyperglycemia, and hypoglycemia in patients with type 2 diabetes.
Impact of age at diagnosis on long‐term prognosis in patients with intestinal Behçet's disease
Authors: Chang Ji Young , Park Soo Jung , Park Jae Jun , Kim Tae Il , Cheon Jae Hee , Park Jihye 
Published: December 2023

AbstractBackground and AimAlthough age at disease onset is considered to be a significant factor in the prognosis of Crohn's disease, little is known about its influence on the long‐term prognosis of those with intestinal Behçet's disease (BD). This study aimed to evaluate the long‐term clinical outcomes of patients with intestinal BD according to age of disease onset.MethodsPatients diagnosed with intestinal BD at < 18, 18–60, and > 60 years of age were classified into early‐onset, adult‐onset, and late‐onset groups, respectively. The influence of disease onset time on clinical prognosis, including specific medical requirements, BD‐related intestinal surgery, hospitalization, and emergency room visits, was compared using the log–rank test in a large cohort of patients with intestinal BD.ResultsAmong 780 patients, 21 (2.7%), 672 (86.2%), and 87 (11.1%) comprised the early‐onset, adult‐onset, and late‐onset groups, respectively. Patients in the early‐onset group were more likely to require immunosuppressants than those in the adult‐onset group (P = 0.048). Nine (42.9%), 158 (23.5%), and 18 (20.7%) patients in the early‐onset, adult‐onset, and late‐onset groups, respectively, underwent intestinal resection. The early‐onset group exhibited a higher risk for intestinal resection than the late‐onset (P = 0.043) and adult‐onset (P = 0.030) groups. The late‐onset group exhibited a higher risk for BD‐related hospitalization than the adult‐onset group (P = 0.023).ConclusionsAge at diagnosis affected the clinical course of intestinal BD, including intestinal surgery, hospitalization, and specific medical requirements. Different treatment strategies should be established according to age at diagnosis.
Social Support, Parenting Self‐Efficacy, and Postpartum Depression Among Chinese Parents: The Actor‐Partner Interdependence Mediation Model
Authors: Zheng Jie , Han Rongrong , Gao Lingling 
Published: December 2023

IntroductionPostpartum depression affects both mothers and fathers. This study aimed to examine the relationships between social support, parenting self‐efficacy, and postpartum depression in Chinese mothers and fathers and assess the mediating effect of parenting self‐efficacy using a dyadic perspective.MethodsA cross‐sectional study was implemented from December 2020 to July 2021 in Guangzhou, China, with 309 pairs of parents. The Edinburgh Postnatal Depression Scale, Social Support Rating Scale, Parenting Sense of Competence Scale‐Efficacy subscale, and sociodemographic data sheet were completed by both parents. Dyadic analysis was conducted using the actor‐partner interdependence mediation model. An actor effect is the relationship between variables within an individual, whereas a partner effect is the relationship between variables in the individual and the dyadic partner.ResultsIn total, 20.7% of mothers and 11.7% of fathers had elevated postpartum depressive symptoms at 6 weeks postpartum. The model revealed 6 actor effects: social support was positively associated with parenting self‐efficacy for mothers (β, 0.39; 95% CI, 0.28‐0.49) and fathers (β, 0.39; 95% CI, 0.30‐0.48) and negatively associated with postpartum depression for mothers (β, −0.22; 95% CI, −0.32 to −0.12) and fathers (β, −0.37; 95% CI, −0.48 to −0.26). Parenting self‐efficacy was negatively associated with postpartum depression in mothers (β, −0.41; 95% CI, −0.53 to −0.29) and fathers (β, −0.24; 95% CI, −0.37 to −0.12). Maternal social support had a partner effect on paternal parenting self‐efficacy (β, 0.14; 95% CI, 0.04‐0.24). Parenting self‐efficacy mediated between social support and postpartum depression for both parents (mothers: β, −0.16; 95% CI, −0.23 to −0.10; fathers: β, −0.10; 95% CI, −0.16 to −0.05).DiscussionPostpartum depression was a dyadic phenomenon. Increasing mother‐centered social support has the potential to improve the parenting self‐efficacy of both parents and reduce the likelihood of postpartum depression.