bluuebunny/crossref_metadata_2025_split huggingface dataset:
Selective inhibition of DNA ligase IV provides additional efficacy to the treatment of anaplastic thyroid cancer
Authors: Sriramareddy Sathya Neelature , Jamakhani Majeed , Vilanova Léa , Brossel Hélène , Staumont Bernard , Hamaidia Malik 
Published: February 2024

BackgroundAlthough the incidence of anaplastic thyroid carcinoma (ATC) is low (2.5% of thyroid cancer cases), this cancer has a very poor prognosis (survival rates &lt; 5 months) and accounts for 14–39% of deaths. Conventional therapies based on surgery in combination with radiotherapy or chemotherapy showed limited effectiveness primarily due to the robust and protective DNA damage response in thyroid cancer cells.MethodsWe used single-cell transcriptomic data from patients with different subtypes of thyroid cancer to study expression of genes involved in homologous recombination (HR) and non-homologous end joining (NHEJ) pathways. Then, we investigated the mechanisms of DNA damage and repair in anaplastic (C643 and Hth74) and papillary (TPC-1) thyroid cancer cell lines. The effect of caffeine (inhibitor of ATM and ATR) and UCN-01 (CHK1 inhibitor) was evaluated in cell cycle progression of thyroid cancer cells after γ‐radiation or doxorubicin treatment. The DNA damage response was monitored after staining of phosphorylated γ-H2AX and 53BP1. Reporter plasmids were used to determine the efficacy of double-strand DNA breaks (DSBs) repair by HR and NHEJ in thyroid cancer cells. We evaluated the combination of selective inhibition of the DNA ligase IV by SCR7 and doxorubicin on cellular apoptosis and tumor growth in xenograft murine models of anaplastic thyroid cancer.ResultsSingle-cell RNA-Seq showed that NHEJ- and HR-related genes are expressed in ATC and PTC patients. We showed that ATC cells undergo mitosis in the presence of unrepaired DNA damage caused by γ‐radiation and doxorubicin treatment. To proliferate and survive, these cells efficiently repair DNA lesions using homologous recombination (HR) and non-homologous end joining (NHEJ). The combination of SCR7 with doxorubicin, significantly increased apoptosis and impaired ATC tumor growth in a xenograft mouse model compared to doxorubicin monotherapy.ConclusionThis study shows the therapeutic value of the combination of a DNA ligase IV inhibitor and DNA-damaging agents (doxorubicin and/or γ-radiation) for the treatment of anaplastic thyroid cancer.
Massive extrapancreatic solid pseudopapillary neoplasm misdiagnosed as hepatic tumor: a case report and literature review
Authors: Guo Jixu , Zhao Qingjuan , Qin Liting , Xie Shengjie , Lu Shiliu , Li Baibei , He Meilin , Xie Linhong , Yu Shuiping 
Published: February 2024

BackgroundSolid pseudopapillary neoplasms (SPNs) of the pancreas are uncommon, low-malignancy neoplasms. Moreover, the occurrence of extrapancreatic SPNs is rarely encountered.Case summaryA 45-year-old female presented with a right upper abdominal mass and abdominal pain for 3 and 1 months as chief complaints, respectively. Initially, the patient was misdiagnosed with hepatocellular carcinoma based on her symptoms and results of physical and imaging examinations. Following multidisciplinary discussion and ruling out surgical contraindications, a decision was taken to proceed with surgical intervention. Interestingly, the tumor was found to originate from the retroperitoneum and had invaded the right half of the liver and the right wall of the inferior vena cava. The operation was uneventful, and the pathological findings confirmed the tumor as an extrapancreatic SPN. The patient remained asymptomatic after 15 months of follow-up.ConclusionSurgical treatment remains the preferred option for extrapancreatic SPN. The preoperative misdiagnosis also highlights the importance of accurate diagnosis and the development of appropriate treatment strategies for liver masses.
Association of immune inflammatory biomarkers with pathological complete response and clinical prognosis in young breast cancer patients undergoing neoadjuvant chemotherapy
Authors: Li Fucheng , Wang Youyu , Dou He , Chen Xingyan , Wang Jianan , Xiao Min 
Published: February 2024

BackgroundThe persistence of inflammatory stimulus has a tight relationship with the development of age-related diseases, ultimately resulting in a gradual escalation in the prevalence of tumors, but this phenomenon is rare in young cancer patients. Breast cancer arising in young women is characterized by larger tumor diameters and more aggressive subtypes, so neoadjuvant chemotherapy (NACT) can be especially appropriate for this population. Immune inflammatory biomarkers have been reportedly linked to the prognosis of some malignant tumor types, with varying results. In this study, we investigated the possible predictive value of blood-based markers in young breast cancer patients undergoing NACT, in addition to the association between the clinicopathological features and prognosis.MethodsFrom December 2011 to October 2018, a total of 215 young breast cancer patients referred to Harbin Medical University Cancer Hospital received NACT and surgery were registered in this retrospective study. The pretreatment complete blood counts were used to calculate the neutrophil-to-lymphocyte ratio (NLR), platelet-to-lymphocyte ratio (PLR), monocyte-to-lymphocyte ratio (MLR), and pan-immune-inflammation value (PIV).ResultsNLR, PLR, MLR, and PIV optimal cut-off values were 1.55, 130.66, 0.24, and 243.19, as determined by receiver operating characteristic analysis. Multivariate analysis revealed that PIV, HR status, HER-2 status, and Ki-67 index were all independent predictive factors for pathological complete response. Subgroup analysis revealed that young breast cancer patients in the population characterized by low PIV and HR negative group were more likely to get pCR (P=0.001). The five-year overall survival (OS) rate was 87.9%, and Cox regression models identified PIV as independently related to OS.ConclusionIn the present study, the pretreatment PIV was found to be a useful prognostic indicator for pCR and long-term survival in young breast cancer patients undergoing NACT. High immune and inflammation levels, MLR and PIV were connected to poor clinical prognosis in young breast cancer patients. PIV is a promising biomarker to guide strategic decisions in treating young breast cancer.
Characterisation of RSV infections in children without chronic diseases aged 0–36 months during the post-COVID-19 winter season 2022/2023
Authors: Meier Katharina , Riepl Angela , Voitl Peter , Lischka Lena , Voitl Julian J. M. , Langer Klara , Kuzio Ulrike , Redlberger-Fritz Monika , Diesner-Treiber Susanne C. 
Published: February 2024

BackgroundRespiratory syncytial virus (RSV) is one of the leading causes of hospitalisation, morbidity, and mortality due to respiratory infection in the first years of life. This longitudinal prospective study outlines the 2022/23 season's viral patterns in Austria after the epidemiological changes determined by public health measures. We aimed to highlight differences within the RSV subtypes and genotypes in 0–36-month-old children without chronic diseases in the outpatient setting.MethodsFrom November 2022 to March 2023 children younger than 36 months admitted to Vienna's largest paediatric primary healthcare centre with an acute respiratory infection were enrolled in this study. Nasal swabs and multiplex PCR panels detected 20 viruses including RSV subtypes and genotypes. Clinical presentation, features, and treatment of the participants were documented and analysed using the Modified Tal Score (MTS). Patients were scheduled for a telemedical follow-up one week after the initial appointment. Analysis was done using descriptive statistics, including Cramér V and binominal logarithmic regression.ResultsAmong the 345 samples from 329 children, RSV was the most common virus (31.9%), followed by influenza (17.5%) and rhinovirus infections (20.58%). Of the RSV positive samples, only 13 cases were RSV subtype A (11.8%), whereas 97 were of subtype B (87.3%); ON1 and BA9 were the only detectable RSV genotypes (ON1: BA9 = 1:9.25). RSV was the main predictor of hospitalisation (OR: 7.5, 95% CI: (1.46–38.40), and age had a significant but smaller effect (OR: 0.89, 95% CI: (0.81–0.99). Almost all patients' clinical status improved within the first days.ConclusionRSV cases showed a rapid onset in late November 2022, and subtype B was predominant throughout the season. RSV infection was associated with higher hospitalisation rates, even after excluding high-risk patients (preterm and severe chronic diseases population).Further testing in the upcoming winter seasons will improve our knowledge of the dominant subtype and its association with disease severity, especially with the development of novel RSV vaccine candidates.
Artificial light at night alters progression of cold neuropathy in a sex-dependent manner in a mouse model of type II diabetes mellitus
Authors: Bumgarner Jacob R. , White Rhett C. , Brown Jordan A. , Nelson Randy J. 
Published: February 2024

Artificial light at night (ALAN) is a pervasive circadian rhythm disruptor. Exposure to ALAN is associated with detrimental effects on physiology and behavior, including disrupted metabolism, immune function, endocrine function, and pain behavior. Given the detrimental effects of ALAN and other circadian rhythm disruptors on pain, we sought to understand how ALAN may alter the progression and severity of diabetic neuropathy. To do this, we used a previously reported high-fat diet and streptozotocin injection protocol to induce a type II diabetic phenotype in ∼8 week old female and male mice and then exposed the mice to either control or ALAN lighting conditions in 14:10 h light-dark cycles for 4 weeks. Male mice housed in control conditions exhibited reduced responsiveness to cold pain; in contrast, ALAN blunted this effect in male mice. ALAN exposure also elevated blood glucose and altered body mass loss in male mice. These effects were not present in female mice. The results of this study highlight the need to consider and study ALAN exposure and sex as a biological variable as risk factors in the treatment and mitigation of pain.
Detection of Candidatus Liberibacter asiaticus and five viruses in individual Asian citrus psyllid in China
Authors: Liu Luqin , Chen Jing , Jiang Junyao , Liang Jiamei , Song Yaqin , Chen Qi , Yan Fuling , Bai Ziqin , Song Zhen , Liu Jinxiang 
Published: February 2024

IntroductionAsian citrus psyllid (ACP, Diaphorina citri) is an important transmission vector of “Candidatus Liberibacter asiaticus” (CLas), the causal agent of Huanglongbing (HLB), the most destructive citrus disease in the world. As there are currently no HLB-resistant rootstocks or varieties, the control of ACP is an important way to prevent HLB. Some viruses of insect vectors can be used as genetically engineered materials to control insect vectors.MethodsTo gain knowledge on viruses in ACP in China, the prevalence of five RNA and DNA viruses was successfully determined by optimizing reverse transcription polymerase chain reaction (RT-PCR) in individual adult ACPs. The five ACP-associated viruses were identified as follows: diaphorina citri bunyavirus 2, which was newly identified by high-throughput sequencing in our lab, diaphorina citri reovirus (DcRV), diaphorina citri picorna-like virus (DcPLV), diaphorina citri bunyavirus (DcBV), and diaphorina citri densovirus-like virus (DcDV).ResultsDcPLV was the most prevalent and widespread ACP-associated virus, followed by DcBV, and it was detected in more than 50% of all samples tested. DcPLV was also demonstrated to propagate vertically and found more in salivary glands among different tissues. Approximately 60% of all adult insect samples were co-infected with more than one insect pathogen, including the five ACP-associated viruses and CLas.DiscussionThis is the first time these viruses, including the newly identified ACP-associated virus, have been detected in individual adult ACPs from natural populations in China’s five major citrus-producing provinces. These results provide valuable information about the prevalence of ACP-associated viruses in China, some of which have the potential to be used as biocontrol agents. In addition, analysis of the change in prevalence of pathogens in a single insect vector is the basis for understanding the interactions between CLas, ACP, and insect viruses.
The impact of coercive and assertive communication styles on children’s perception of chores: an experimental investigation
Authors: Marici Marius , Runcan Remus , Cheia Gheorghe , David Gheorghe 
Published: February 2024

IntroductionThis article presents the findings of an experimental study aimed at investigating the impact of coercive and assertive communication on children’s emotional responses and behavioral tendencies within parent–child interactions.MethodsThe study tested four hypotheses related to children’s feelings, personalization bias, the need to express their point of view, and the desire to retreat to their room alone. Short audio stimuli recorded by a female assistant, representing a mother addressing her child, were utilized to create five different communication situations. The experimental procedure involved participants listening to the audio stimuli and answering related questions. The study included 123 participants between the ages of 9 and 13, with an equal gender distribution.ResultsThe results of One-Way ANOVA tests indicated significant differences among the four types of communication in terms of unpleasant feelings, personalization bias, listening to a personal point of view, and retreating into a personal room. The findings suggest that coercive communication elicited more negative emotional responses and stronger tendencies toward personalization bias, expressing personal opinions, and seeking solitude compared to assertive communication.DiscussionThe implications of these findings highlight the importance of promoting positive and respectful communication strategies in parent–child relationships to foster children’s emotional well-being and healthy behavioral development.
Determinants of unmet needs for mental health services amongst adolescents in Shiraz, Iran: a cross-sectional study
Authors: Joulaei Hassan , Fatemi Maryam , Joulaei Razieh , Heydari Mohammad Reza , Pourmontaseri Ahmad Reza , Foroozanfar Zohre 
Published: February 2024

BackgroundMental disorders are increasingly prevalent among adolescents without appropriate response. There are a variety of reasons for unmet mental health needs, including attitudinal and structural barriers. Accordingly, we investigated perceived mental health needs, using mental health services, and their barriers in adolescents.MethodThis cross-sectional study was conducted in 2022 in Shiraz, Iran. Demographic characteristics, the Adolescent Unmet Needs Checklist, and the Young Schema Questionnaire were administered to 348 adolescents aged 13–19 years. Adolescents were classified as having no needs, fully met needs, partially met needs, or wholly unmet needs. Logistic regression analysis was used to determine factors associated with perceived unmet need and refer participants to healthcare centers.Results193 (55.5%) adolescents reported perceived need for mental healthcare out of whom, 21.6% reported fully and 21.6% partially unmet needs. Noticeably, only 12.4% of needy participants reported met need. “Reluctance to seek mental healthcare” and “asked but not receiving help” were common barriers to using the services.ConclusionThe present study reveals unmet mental healthcare needs as a significant public health concern among the adolescents. To address this significant concern, reorientation of primary care, removing economic barriers from mental healthcare services, and improving health literacy in the community are recommended.
New perspectives on assessment and understanding of the patient with cranial bone defect: a morphometric and cerebral radiodensity assessment
Authors: Oliveira Arthur Maynart Pereira , De Andrade Almir Ferreira , Pipek Leonardo Zumerkorn , Iaccarino Corrado , Rubiano Andres M. , Amorim Robson Luis , Teixeira Manoel Jacobsen , Paiva Wellingson Silva 
Published: February 2024

BackgroundSkull defects after decompressive craniectomy (DC) cause physiological changes in brain function and patients can have neurologic symptoms after the surgery. The objective of this study is to evaluate whether there are morphometric changes in the cortical surface and radiodensity of brain tissue in patients undergoing cranioplasty and whether those variables are correlated with neurological prognosis.MethodsThis is a prospective cohort with 30 patients who were submitted to cranioplasty and followed for 6 months. Patients underwent simple head CT before and after cranioplasty for morphometric and cerebral radiodensity assessment. A complete neurological exam with Mini-Mental State Examination (MMSE), modified Rankin Scale, and the Barthel Index was performed to assess neurological prognosis.ResultsThere was an improvement in all symptoms of the syndrome of the trephined, specifically for headache (p = 0.004) and intolerance changing head position (p = 0.016). Muscle strength contralateral to bone defect side also improved (p = 0.02). Midline shift of intracranial structures decreased after surgery (p = 0.004). The Anterior Distance Difference (ADif) and Posterior Distance Difference (PDif) were used to assess morphometric changes and varied significantly after surgery. PDif was weakly correlated with MMSE (p = 0.03; r = −0.4) and Barthel index (p = 0.035; r = −0.39). The ratio between the radiodensities of gray matter and white matter (GWR) was used to assess cerebral radiodensity and was also correlated with MMSE (p = 0.041; r = −0.37).ConclusionMorphological anatomy and radiodensity of the cerebral cortex can be used as a tool to assess neurological prognosis after DC.
Optimalisasi Hasil Pengabdian Dosen Melalui Pembuatan Jurnal Abdimas Berbasis Open Journal System (OJS) di IPDN Kampus NTB
Authors: Wahyudi Erfan 
Published: February 2024

Abstrak – Penelitian ini mencoba untuk membangun sebuah jurnal pengabdian masyarakat yang berbasis OJS di IPDN Kampus NTB yang dapat digunakan sebagai bentuk manajemen publikasi dan penerbitan artikel hasil pengabdian kepada masyarakat Dosen di IPDN Kampus NTB. Diharapkan dengan adanya OJS ini dapat meningkatkan publikasi dan manajemen penerbitan secara elektronik serta sepenuhnya dilaksanakan dengan baik oleh author, editor maupun mitra bestari (reviewer) di lingkungan IPDN Kampus NTB. Metode yang digunakan dalam pengembangan sistem dalam penelitian ini adalah Metode Waterfall. Setelah penelitian dilaksanakan, hasilnya adalah IPDN Kampus NTB memiliki jurnal pengabdian masyarakat yang bisa digunakan untuk mempublikasikan jurnal dosen tersebut dapat meningkatkan KUM pada Penilaian Angka Kredit (PAK) untuk kenaikan pangkat dan laporan BKD Dosen setiap semesternya. Penerbitan perdana jurnal ini direncanakan pada Januari 2024 dan dapat menampung minimal 10 artikel dalam setiap edisi.
Abstract - This research tries to build an OJS-based community service journal at IPDN NTB Campus which can be used as a form of publication management and publishing articles resulting from community service for lecturers at IPDN NTB Campus. It is hoped that this OJS can improve electronic publications and publishing management and be fully implemented well by authors, editors and bestari partners (reviewers) within the IPDN NTB Campus. The method used in system development in this research is the Waterfall Method. After the research was carried out, the result was that IPDN NTB Campus had a community service journal which could be used to publish lecturer journals which could increase the KUM in the Credit Score Assessment (PAK) for promotions and BKD Lecturer reports every semester. The first publication of this journal is planned for January 2024 and can accommodate a minimum of 10 articles in each edition.
Implementasi E-Journal berbasis Open Journal System (OJS) untuk Meningkatkan Jumlah Publikasi Penelitian Dosen IPDN Kampus NTB
Authors: Wahyudi Erfan 
Published: February 2024

Penelitian ini bertujuan untuk membangun dan mengimplementasikan e-journal berbasis Open Journal System (OJS) untuk meningkatkan jumlah publikasi penelitian Dosen di IPDN Kampus NTB yang dapat digunakan sebagai bentuk manajemen publikasi dan penerbitan artikel hasil penelitian Dosen dan Praja di IPDN Kampus NTB. Diharapkan dengan adanya OJS ini dapat meningkatkan publikasi dan manajemen penerbitan secara elektronik serta sepenuhnya dilaksanakan dengan baik oleh author, editor maupun mitra bestari (reviewer) di lingkungan IPDN Kampus NTB. Metode yang digunakan dalam pengembangan sistem dalam penelitian ini adalah Metode Waterfall. Setelah penelitian dilaksanakan, hasilnya pembuatan website jurnal berbasis OJS berhasil dan siap untuk diterapkan serta melakukan proses penerbitan jurnal pada volume 1 tahun 2024.
Abstract - This research aims to build and implement an e-journal based on the Open Journal System (OJS) to increase the number of lecturer research publications at the IPDN NTB Campus which can be used as a form of publication management and publishing articles resulting from research by Lecturers and Teachers at the IPDN NTB Campus. It is hoped that this OJS can improve electronic publications and publishing management and be fully implemented well by authors, editors and bestari partners (reviewers) within the IPDN NTB Campus. The method used in system development in this research is the Waterfall Method. After the research was carried out, the result was that the creation of an OJS-based journal website was successful and ready to be implemented and carry out the process of publishing the journal in volume 1 in 2024.
لاستخدام الاجتماعي لتكنولوجيا الاتصال الانترنت نموذجا: مقاربة نظرية.
Authors: عبدلي احمد 
Published: February 2024

يشكل " الاستخدام الاجتماعي لتكنولوجيا الاتصال " حقلا معرفيا مميزا قائما بذاته، ذي بعد نظري ومنهجي يهتم بالأساس بتوصيف طبيعة العلاقة التي تجمع بين "الإنسان" المستخدم والأداة الاتصالية الجديدة، وهو مفهوم يقابله مفهوم "التعرض" لوسائل الإعلام التقليدية . تهتم الأبحاث المتعلقة بهذه الظاهرة عادة بتحليلها مفاهيميا بتحديد الخصائص والصفات والسمات العامة والخاصة لهذا المفهوم، ومحاولة استخلاص المعنى الاجتماعي والثقافي من المعطى التقني، وكذا وضع اطر عامة لاتجاهات البحث فيها، وأخير تحليل الإطار الكلي الذي تتم فيه العملية، بهدف الوصول إلى تبصرات بها في الحال والمآل، وهو ما تسعى هذه الورقة إلى تفصيله وبيانه.
الكلمات المفتاحية:تكنلوجيا،إنصال ،إعلام جديد،إجتماعي،تحليل.
Perbandingan Performa Keuangan Pt Bumi Serpong Damai Tbk. Dan Pt Rockfields Properti Indonesia Tbk. Periode Tahun 2021 - 2022
Authors: Hazwan Iskandar Jaya Hazwan Iskandar Jaya , Partinem Partinem , Sri Wulansari Sri Wulansari , Wanda Prihanto Asmoro Wanda Prihanto Asmoro , Sri Hermuningsih Sri Hermuningsih 
Published: February 2024

Penelitian ini dilakukan untuk membandingkan performa rasio keuangan PT Bumi Serpong Damai Tbk dan PT Rockfields Properti Indonesia Tbk. selama periode 2021 hingga 2022 dilihat dari Rasio Likuiditas yang terdiri dari Current Ratio, Rasio Solvabilitas, dan Rasio Profitabilitas. Hasil penelitian menunjukkan bahwa perbandingan kinerja keuangan PT. Bumi Serpong Damai Tbk dan PT. Rockfields Properti Indonesia Tbk. Dilihat dari likuditas masing-masing, pada current ratio PT. Bumi Serpong Damai Tbk lebih unggul dibanding PT. Rockfields Properti Indonesia Tbk. Sedangkan kemampuan membayar utang PT. Bumi Serpong Damai Tbk. lebih baik dibandingkan PT. Rockfields Properti Indonesia Tbk. Dari sisi profitabilitas, PT. Bumi Serpong Damai Tbk lebih baik menghasilkan laba dengan seluruh aset yang dimiliki dibanding PT. Rockfields Properti Indonesia Tbk.