bluuebunny/crossref_metadata_2025_split huggingface dataset:
A novel trajectory similarity measurement method based on node‐sequence hierarchical digraph
Authors: Fan Yue , Wang Huiwen , Wang Lihong , Guo Shu , Liu Jing 
Published: December 2023

AbstractTrajectory similarity measurement is a basic and vital task in trajectory data mining, which has attracted extensive research in the past decades. Recent works focused on the sequence and hierarchy property of trajectories to construct similarity measurements. However, these methods ignore the user information on the visiting locations, such as semantic and time distribution. In light of this, a novel trajectory similarity measurement based on Node‐Sequence Hierarchical Digraph (NSHD) framework is proposed in this article. We first propose a Time‐Weighted Stay Point Detection (TWSPD) method to extract real visiting locations of users more accurately. Then, the nodes of digraph are obtained by clustering users' stay points and the edges of digraph are sequence information that users move between these nodes. An Advanced Earth Mover's Distance (AEMD) is proposed to measure the node similarity between users, considering visiting time distribution and semantic information simultaneously. Both node and sequence similarities are used to calculate the similarity score to obtain the final trajectory similarity measurement. Experiments on Geolife and T‐Drive datasets show that our proposed method offers competitive performance with mean reciprocal rank values reaching 96.01 and 81.26%, which outperforms related trajectory similarity measurements by more than 10 and 15%.
Domestic colonisation: The centrality of the home in experiences of home‐takeovers and hate relationships
Authors: Clayton John , Donovan Catherine , Macdonald Stephen J. 
Published: December 2023

AbstractIn this paper we introduce the concept of ‘domestic colonisation’ as a contribution to the literature on critical geographies of home. This provides a lens to focus on the ways in which domestic spaces might be exploited and/or dominated though familiar relationships. With reference to two research projects in North East England, we explore everyday occupations and sieges of home‐spaces by neighbours as a means of reinforcing positions of relative social advantage. We show how these experiences become overwhelming through the intrusion of home‐spaces and (with it) the life worlds of already structurally vulnerable(ised) communities. Domestic colonisation allows us to think through both the damage done through/to the home and connections beyond those spaces. To do this we focus on ‘home takeovers’ (or ‘cuckooing’) and ‘hate relationships’. Our work on cuckooing shows how the occupation and control of the home by those who re‐produce and seize upon structurally vulnerable(ised) people, is a process which re‐configures the home as an exploitable resource. Understandings of home and intimate social relationships as ‘private’, combined with complexities regarding culpability, conceal the damage done in contexts of diminished social infrastructure. With reference to our work on hate relationships, we outline how homes are a means of identifying and targeting those who become subjected to a range of hateful acts. This produces everyday spaces of siege and entrapment that control, immobilise and are difficult to escape. Formal interventions are unable to adequately support those victimised through lack of recognition, misrecognition as atomised disputes and a tendency to (re)move those victimised. We end by questioning how we might better address the needs of those subjected to such harms, with an emphasis on the relational production of the home.
Process conditions affect microbial diversity and activity in a haloalkaline biodesulfurization system
Authors: Gupta Suyash , de Rink Rieks , Klok Johannes B. M. , Muyzer Gerard , Plugge Caroline M. 
Published: December 2023

ABSTRACT

Biodesulfurization (BD) systems that treat sour gas employ mixtures of haloalkaliphilic sulfur-oxidizing bacteria to convert sulfide to elemental sulfur. In the past years, these systems have seen major technical innovations that have led to changes in microbial community composition. Different studies have identified and discussed the microbial communities in both traditional and improved systems. However, these studies do not identify metabolically active community members and merely focus on members’ presence/absence. Therefore, their results cannot confirm the activity and role of certain bacteria in the BD system. To investigate the active community members, we determined the microbial communities of six different runs of a pilot-scale BD system. 16S rRNA gene-based amplicon sequencing was performed using both DNA and RNA. A comparison of the DNA- and RNA-based sequencing results identified the active microbes in the BD system. Statistical analyses indicated that not all the existing microbes were actively involved in the system and that microbial communities continuously evolved during the operation. At the end of the run, strains affiliated with
Alkalilimnicola ehrlichii
and
Thioalkalivibrio sulfidiphilus
were confirmed as the most active key bacteria in the BD system. This study determined that microbial communities were shaped predominantly by the combination of hydraulic retention time (HRT) and sulfide concentration in the anoxic reactor and, to a lesser extent, by other operational parameters.

IMPORTANCE
Haloalkaliphilic sulfur-oxidizing bacteria are integral to biodesulfurization (BD) systems and are responsible for converting sulfide to sulfur. To understand the cause of conversions occurring in the BD systems, knowing which bacteria are present and active in the systems is essential. So far, only a few studies have investigated the BD system’s microbial composition, but none have identified the active microbial community. Here, we reveal the metabolically active community, their succession, and their influence on product formation.
Confirmation of the New Evolutionary Status of UU Cas
Authors: Gorda S. Yu. 
Published: December 2023

Abstract
A new spectral study of the close binary system (CBS) UU Cas with massive components was carried out, based on spectra obtained on the echelle spectrometer of the 1.2-m telescope of Kourovka Astronomical Observatory of UFU from 2017 to 2022. The results of this study confirm the new evolutionary status of UU Cas, previously determined by the author based on spectrophotometry of this system in 2017 and confirmed in a number of works by other researchers, according to which the system is in the final stage of the mass exchange process, and not at its beginning, as previously thought. Its components are not very massive, and the value of their mass ratio is the opposite of what was previously determined from photometry results. The values of the half-amplitudes of the radial velocities $${{K}_{1}} = 195.6$$ km/s, $${{K}_{2}} = 106.5$$ km/s and the masses of both components $${{M}_{1}} = 9.6\;{{M}_{ \odot }}$$, $${{M}_{2}} = 17.6\;{{M}_{ \odot }}$$ obtained on a much more extensive observational material, for the orbital inclination angle i = 74.5°, given recently in the literature, as well as the orbital radius $$A = 54\;{{R}_{ \odot }}$$ of this close binary system are comparable with the values previously found by the author. The article is based on a talk presented at the astrophysical memorial seminar “Novelties in Understanding the Evolution of Binary Stars,” dedicated to the 90th anniversary of Professor M.A. Svechnikov.
Prediction of ileal digestible phosphorus in broiler chicken diets supplemented with exogenous phytase
Authors: Sung Jung Yeol , Adeola Olayiwola 
Published: December 2023

The objectives were to develop equations for predicting ileal digestible phosphorus (P) based on nonphytate P, phytate P, calcium to nonphytate P ratio, and exogenous phytase concentrations in broiler diets and to evaluate the accuracy of the models. The modified Michaelis–Menten model was used to predict apparent ileal digestible (AID) or standardized ileal digestible P in broiler diets. Two different methods were used to analyze 25 published ileal digestible P data to evaluate the accuracy of the equation for predicting AID P. The first method assessed mean and linear biases. While the mean bias was significant ( P < 0.05), the linear bias was not significant. The second method involved regressing the 25 AID P data against those predicted by the current model. The results showed that the intercept and slope of the regression were not statistically different from 0 and 1, respectively. This suggests that the current equation accurately represents the test data. In conclusion, the accuracy of the model depends on validation processes. Considering that the current model was developed using various phytase products, it would be preferable to use an equation that is based on a single phytase product if requisite quantity of data is available.
Jet grouting to new depths in the Lambeth Group and Thanet Formation beneath London
Authors: Newman T. G. , Skarda A. J. 
Published: December 2023

A jet grouting trial was undertaken within the Thames Tideway Tunnel shaft at Kirtling Street in Battersea, SW London, to assess the viability of the technique within the Lambeth Group and Thanet Formation sediments up to 60 m below ground level.
There was no precedent industry experience of jet grouting in the UK at this depth and in these soil types.
Four, separate, upper and lower grout columns were constructed respectively within upper and lower granular zones inside the shaft footprint, and then exhumed for inspection and measurement during ensuing excavation within the diaphragm wall lining. Target diameters for the upper columns were achieved within granular channel sand and Laminated Bed material, with minimal vertical deviation. These were not so successfully achieved, however, within stiff cohesive Laminated Bed and Lower Shelly Clay materials.
Formation of the lower columns was severely restricted in dense gravel belonging to the ‘Pebble Bed’ and stiff gravelly clay, at the top of the Upnor Formation, but target diameters were being achieved in the lower portion of the formation, comprising Upnor sand. At their base, the column diameters were, again, restricted in the very dense sand at the top of the Thanet Formation.
Development of a Practical Nomogram for Personalized Anemia Management in Patients Treated with Ataxia Telangiectasia and Rad3-related Inhibitor Camonsertib
Authors: Rosen Ezra , Yap Timothy A. , Lee Elizabeth K. , Højgaard Martin , Mettu Niharika B. , Lheureux Stephanie , Carneiro Benedito A. , Plummer Ruth , Fretland Adrian J. , Ulanet Danielle , Xu Yi , McDougall Robin , Koehler Maria , Fontana Elisa 
Published: December 2023

Abstract

Purpose:
Camonsertib is a highly selective and potent inhibitor of ataxia telangiectasia and Rad3-related (ATR) kinase. Dose-dependent anemia is a class-related on-target adverse event often requiring dose modifications. Individual patient risk factors for the development of significant anemia complicate the selection of a “one-size-fits-all” ATR inhibitor (ATRi) dose and schedule, possibly leading to suboptimal therapeutic doses in patients at low risk of anemia. We evaluated whether early predictors of anemia could be identified to ultimately inform a personalized dose-modification approach.

Patients and Methods:
On the basis of preclinical observations and a mechanistic understanding of ATRi-related anemia, we identified several potential factors to explore in a multivariable linear regression modeling tool for predicting hemoglobin level ahead of day 22 (cycle 2) of treatment.

Results:
In patients treated with camonsertib monotherapy (NCT04497116), we observed that hemoglobin decline is consistently preceded by reticulocytopenia, and dose- and exposure-dependent decreases in monocytes. We developed a nomogram incorporating baseline and day 8 hemoglobin and reticulocyte values that predicted the day 22 hemoglobin values of patients with clinically valuable concordance (within 7.5% of observations) 80% of the time in a cross-validation performance test of data from 60 patients.

Conclusions:
The prediction of future hemoglobin decrease, after a week of treatment, may enable a personalized, early dose modification to prevent development of clinically significant anemia and resulting unscheduled dose holds or transfusions.
Comparison of Circulating Tumor DNA Assays for Molecular Residual Disease Detection in Early-Stage Triple-Negative Breast Cancer
Authors: Coakley Maria , Villacampa Guillermo , Sritharan Prithika , Swift Claire , Dunne Kathryn , Kilburn Lucy , Goddard Katie , Pipinikas Christodoulos , Rojas Patricia , Emmett Warren , Hall Peter , Harper-Wynne Catherine , Hickish Tamas , Macpherson Iain , Okines Alicia , Wardley Andrew , Wheatley Duncan , Waters Simon , Palmieri Carlo , Winter Matthew , Cutts Rosalind J. , Garcia-Murillas Isaac , Bliss Judith , Turner Nicholas C. 
Published: December 2023

Abstract

Purpose:
Detection of circulating tumor DNA (ctDNA) in patients who have completed treatment for early-stage breast cancer is associated with a high risk of relapse, yet the optimal assay for ctDNA detection is unknown.

Experimental Design:
The cTRAK-TN clinical trial prospectively used tumor-informed digital PCR (dPCR) assays for ctDNA molecular residual disease (MRD) detection in early-stage triple-negative breast cancer. We compared tumor-informed dPCR assays with tumor-informed personalized multimutation sequencing assays in 141 patients from cTRAK-TN.

Results:
MRD was first detected by personalized sequencing in 47.9% of patients, 0% first detected by dPCR, and 52.1% with both assays simultaneously (P &lt; 0.001; Fisher exact test). The median lead time from ctDNA detection to relapse was 6.1 months with personalized sequencing and 3.9 months with dPCR (P = 0.004, mixed-effects Cox model). Detection of MRD at the first time point was associated with a shorter time to relapse compared with detection at subsequent time points (median lead time 4.2 vs. 7.1 months; P = 0.02).

Conclusions:
Personalized multimutation sequencing assays have potential clinically important improvements in clinical outcome in the early detection of MRD.
Role of N6-methyladenosine methylation in glioma: recent insights and future directions
Authors: Li Chunlin , Li Bowen , Wang Hui , Qu Linglong , Liu Hui , Weng Chao , Han Jinming , Li Yuan 
Published: December 2023

AbstractGlioma is the most pervasive intracranial tumor in the central nervous system (CNS), with glioblastoma (GBM) being the most malignant type having a highly heterogeneous cancer cell population. There is a significantly high mortality rate in GBM patients. Molecular biomarkers related to GBM malignancy may have prognostic values in predicting survival outcomes and therapeutic responses, especially in patients with high-grade gliomas. In particular, N6-methyladenine (m6A) mRNA modification is the most abundant form of post-transcriptional RNA modification in mammals and is involved in regulating mRNA translation and degradation. Cumulative findings indicate that m6A methylation plays a crucial part in neurogenesis and glioma pathogenesis. In this review, we summarize recent advances regarding the functional significance of m6A modification and its regulatory factors in glioma occurrence and progression. Significant advancement of m6A methylation-associated regulators as potential therapeutic targets is also discussed.
When chronic obstructive pulmonary disease meets small cell lung cancer: an unusual case report of rapid progression
Authors: Zhang Xu , Zeng Jia , Huang Xiyu , Li Zhishu 
Published: December 2023

Abstract
Background
Chronic obstructive pulmonary disease (COPD) is a chronic inflammatory disease and a risk factor for lung cancer. Small cell lung cancer is a neuroendocrine tumor with a high degree of malignancy and an overall five-year survival rate of less than 7%.

Cases presentation
Herein, we report the case of an 68-year-old male presented to the respiratory department with cough, sputum, and dyspnea.
He was diagnosed as community acquired pneumonia and treated with intravenous anti-infection. Previous pulmonary function was definitively diagnosed as COPD. About 7 months after discharge, the patient returned to the hospital for cough and dyspnea. After diagnosis of the tumor, cisplatin, etoposide and durvalumab were administered. Finally the patient died of respiratory failure approximately 9 months after his diagnosis.

Conclusions
For COPD patients with immunocompromised manifestations, it is necessary to be alert to complications and shorten the follow-up interval of chest CT. COPD may accelerate the formation and progression of SCLC.
Cellulitis caused by Roseomonas mucosa in a child: a case report
Authors: Matsuhisa Yuki , Kenzaka Tsuneaki , Hirose Hideo , Gotoh Tadao 
Published: December 2023

Abstract
Background
Roseomonas mucosa (R. mucosa) is a pink-pigmented, Gram-negative short rod bacterium. It is isolated from moist environments and skin, resistant to multiple drugs, including broad-spectrum cephalosporins, and a rare cause of infection with limited reports. R. mucosa mostly causes catheter-related bloodstream infections, with even fewer reports of skin and soft tissue infections.

Case presentation
A 10-year-old boy received topical steroid treatment for sebum-deficient eczema. A few days before the visit, he was bitten by an insect on the front of his right lower leg and scratched it due to itching. The day before the visit, redness, swelling, and mild pain in the same area were observed. Based on his symptoms, he was diagnosed with cellulitis. He was treated with sulfamethoxazole/trimethoprim, and his symptoms improved. Pus culture revealed R. mucosa.

Conclusions
We report a rare case of cellulitis caused by R. mucosa. Infections caused by rare organisms that cause opportunistic infections, such as R. mucosa, should be considered in patients with compromised skin barrier function and regular topical steroid use. Gram stain detection of organisms other than Gram-positive cocci should be considered.
Non-pharmacological therapy for chemotherapy-induced peripheral neurotoxicity: a network meta-analysis of randomized controlled trials
Authors: Zhang Xia , Wang Ao , Wang Miaowei , Li Guo , Wei Quan 
Published: December 2023

Abstract
Background
Chemotherapy-induced peripheral neurotoxicity (CIPN) is the most common adverse effect in patients undergoing chemotherapy, and no effective interventions are currently available for its prevention and treatment. Non-pharmacological therapies appear to be beneficial for the prevention and treatment of CIPN, but it remains unclear which therapy is most effective. The aim of this study was to identify the most effective non-pharmacological therapy for CIPN patients.

Methods
PubMed, Web of Science, Embase, and Cochrane Library were searched for randomized controlled trials on non-pharmacological therapies for CIPN. The primary outcomes included pain and peripheral neuropathological symptoms, and the secondary outcomes included quality of life, sensory and motor symptoms. The pairwise analysis and a network meta-analysis were performed using a random effects model.

Results
A total of 46 articles were included in this study, involving 2,878 participants. Our study showed that massage was more effective in pain-alleviating compared with acupuncture [SMD = 0.81, 95%CI (0.04, 1.57)], vitamin and gabapentin [SMD = 2.56, 95%CI (1.39, 3.74)], and usual care and placebo [SMD = 0.9, 95%CI (0.31, 1.49)]. As for attenuating peripheral neuropathological symptoms, massage was more effective than usual care and placebo [SMD = 0.75, 95%CI (0.33, 1.17)], sensorimotor training [SMD = 1.17, 95%CI (0.24, 2.10)], electrostimulation [SMD=-1.18, 95%CI (-2.14, -0.21)], multimodal exercise [SMD=-0.82, 95%CI (-1.57, -0.08)], and resistance training [SMD = 1.03, 95%CI (0.11, 1.95)]. Massage was also more effective than other non-pharmacological therapies in improving quality of life, sensory and motor symptoms.

Conclusions
According to our study, massage has advantages in alleviating pain, improving quality of life, and improving peripheral neuropathological symptoms and has better effect than other non-pharmacological interventions, representing certain clinical significance. However, the results of this study should be interpreted with caution due to the limitations of the included studies. In the future, more high-quality multi arm randomized controlled trials can be attempted to provide direct comparisons of the relative effects of non-pharmacological interventions.
Adjunct prednisone in community-acquired pneumonia: 180-day outcome of a multicentre, double-blind, randomized, placebo-controlled trial
Authors: Blum Claudine A. , Roethlisberger Eva A. , Cesana-Nigro Nicole , Winzeler Bettina , Rodondi Nicolas , Blum Manuel R. , Briel Matthias , Mueller Beat , Christ-Crain Mirjam , Schuetz Philipp 
Published: December 2023

Abstract
Background
Several trials and meta-analyses found a benefit of adjunct corticosteroids for community-acquired pneumonia with respect to short-term outcome, but there is uncertainty about longer-term health effects. Herein, we evaluated clinical outcomes at long term in patients participating in the STEP trial (Corticosteroid Treatment for Community-Acquired Pneumonia).

Methods
This predefined secondary analysis investigated 180-day outcomes in 785 adult patients hospitalized with community-acquired pneumonia included in STEP, a randomised, placebo-controlled, double-blind trial. The primary endpoint was time to death from any cause at 180 days verified by telephone interview. Additional secondary endpoints included pneumonia-related death, readmission, recurrent pneumonia, secondary infections, new hypertension, and new insulin dependence.

Results
From the originally included 785 patients, 727 were available for intention-to-treat analysis at day 180. There was no difference between groups with respect to time to death from any cause (HR for corticosteroid use 1.15, 95% CI 0.68 to 1.95, p = 0.601). Compared to placebo, corticosteroid-treated patients had significantly higher risks for recurrent pneumonia (OR 2.57, 95% CI 1.29 to 5.12, p = 0.007), secondary infections (OR 1.94, 95% CI 1.25 to 3.03, p = 0.003) and new insulin dependence (OR 8.73, 95% CI 1.10 to 69.62, p = 0.041). There was no difference regarding pneumonia-related death, readmission and new hypertension.

Conclusions
In patients with community-acquired pneumonia, corticosteroid use was associated with an increased risk for recurrent pneumonia, secondary infections and new insulin dependence at 180 days. Currently, it is uncertain whether these long-term adverse effects outweigh the short-term effects of corticosteroids in moderate CAP.

Trial registration
This trial was registered with ClinicalTrials. gov, number NCT00973154 before the recruitment of the first patient. First posted: September 9, 2009. Last update posted: April 21, 2015.