bluuebunny/crossref_metadata_2025_split huggingface dataset:
Characteristics and medical practices of hospitalized patients with anti-N-methyl-D-aspartate receptor encephalitis associated with ovarian teratoma in Japan: a retrospective cohort study
Authors: Aoyama Yoko , Kinjo Yasuyuki , Hoshino Kaori , Harada Hiroshi , Ueda Taeko , Kurita Tomoko , Yoshino Kiyoshi , Matsuda Shinya 
Published: November 2023

Abstract

Background
The incidence of anti-N-methyl-D-aspartate receptor (NMDAR) encephalitis and the proportion of patients with ovarian teratoma with complications are unclear. The proportion of those who become severely ill and the percentage of those undergoing medical treatment for severe cases are also unknown. Therefore, in this study, we aimed to investigate the characteristics and medical practice of hospitalized patients with ovarian teratomas complicated by NMDAR encephalitis in Japan.
Results
Patients with ovarian teratoma and encephalitis had a lower median age than those without encephalitis. The group with ovarian teratoma complicated with anti-NMDAR encephalitis was more likely to be transported by ambulance and had more transfers from other hospitals than the group without the complication. Among the target hospitalized patients, the 15 − 19 age group had the highest incidence rates. The median age was lower for steroid pulse therapy, intravenous immunoglobulin therapy, and plasma exchange therapy in that order. Additionally, younger patients underwent more invasive treatments.
Conclusion
Anti-NMDAR encephalitis associated with ovarian tumors often occurs in young people in their late teens and 20s, and younger patients are more likely to be severely ill.
Mast cell-derived TSLP triggers an allergic response, thereby suppressing the early stage of melanoma development
Authors: Kim Hee-Yun , Rah So-Young , Kang Ho-Geun , Kim Hyung-Min , Jeong Hyun-Ja 
Published: November 2023

Abstract
An allergic reaction is a hypersensitive immune reaction. Patients with allergic disorders have a lower incidence of certain cancers. Nevertheless, the role and underlying detailed mechanisms of allergic reaction in cancer development remain obscure. We sought to investigate the role of mast cell-mediated allergic reaction in the early stage of melanoma development. B16F10 melanoma-bearing animal models and in vitro models were used to examine the function and precise mechanism of mast cell-mediated allergic reactions in the melanoma development. Here, we revealed that mast cell-mediated allergic reaction caused autophagy and apoptosis in melanoma by raising thymic stromal lymphopoietin (TSLP) levels, resulting in improved survival of tumor control mice. Targeted depletion of TSLP decreased survival in tumor control mice, whereas TSLP injection increased survival through boosting allergic responses. Single-cell RNA sequencing analysis revealed that TSLP decreased the number of melanocytes, increased the number of T cells, and raised the levels of mast cell-derived allergy-promoting factors compared to tumor control. Moreover, TSLP enhanced the immune response and allergic reactions in immunodeficient mice, resulting in the suppression of melanoma development. Coincidently, patients with melanoma had lower serum levels of TSLP than healthy individuals. Furthermore, in vitro stimulation of melanocytes with mast cell-derived TSLP prompted apoptosis of melanoma by inducing the autophagy. Therefore, our findings suggest that mast cell-derived TSLP directly/indirectly suppressed the early stage of melanoma development by enhancing immunity through triggering allergic reactions.
Autonomous nanorobots with powerful thrust under dry solid-contact conditions by photothermal shock
Authors: Zhaoqi Gu , Zhu Runlin , Shen Tianci , Dou Lin , Liu Hongjiang , Liu Yifei , Liu Xu , Liu Jia , Zhuang Songlin , Gu Fuxing 
Published: November 2023

Abstract

Nanorobotic motion on solid substrates is greatly hindered by strong nanofriction, and powerful nanomotors‒the core components for nanorobotic motion‒are still lacking. Optical actuation addresses power and motion control issues simultaneously, while conventional technologies with small thrust usually apply to fluid environments. Here, we demonstrate micronewton-thrust nanomotors that enable the autonomous nanorobots working like conventional robots with precise motion control on dry surfaces by a photothermal-shock technique. We build a pulsed laser-based actuation and trapping platform, termed photothermal-shock tweezers, for general motion control of metallic nanomaterials and assembled nanorobots with nanoscale precision. The thrust-to-weight ratios up to 107 enable nanomotors output forces to interact with external micro/nano-objects. Leveraging machine vision and deep learning technologies, we assemble the nanomotors into autonomous nanorobots with complex structures, and demonstrate multi-degree-of-freedom motion and sophisticated functions. Our photothermal shock-actuation concept fundamentally addresses the nanotribology challenges and expands the nanorobotic horizon from fluids to dry solid surfaces.
Caproic acid production through fermentation with a novel thermotolerant Clostridium strain M1NH
Authors: Kurniawan Edy , O-Thong Sompong , Imai Tsuyoshi 
Published: November 2023

Abstract

Thermotolerant caproic acid-producing bacteria were isolated from sewage sludge and evaluated for caproic acid production with various substrates. The ethanol-acetate was the most efficient substrate for enriched culture, with 2.7 g/L caproic acid and a yield of 47%. Clostridium strain M1NH was isolated from enriched culture and identified as a gram-positive, rod-shaped, spore-forming with 92% similarity of 16S rRNA to Clostridium kluyveri. Clostridium M1NH has an optimal pH and temperature of 6-6.5 and 35–40°C with a growth rate of 0.11–0.14 h-1, suggesting that the strain was thermotolerant. Clostridium strain M1NH displays the highest caproic acid production of 3.2–3.5 g/L at a pH of 6.5, a temperature of 35–40°C, and an ethanol-acetate molarity ratio of 4:1. Clostridium strain M1NH is tolerant to concentrations of ethanol, acetate, and caproic acid of 5%, 5%, and 2%, respectively. The thermotolerant Clostridium M1NH presents a significant advancement in harnessing sustainable biobased production processes, holding great promise for applications in thermotolerant fermentation.
Caproic acid production through fermentation with a thermotolerant Clostridium strain M1NH
Authors: Kurniawan Edy , O-Thong Sompong , Imai Tsuyoshi 
Published: November 2023

Abstract

Thermotolerant caproic acid-producing bacteria were isolated from sewage sludge and evaluated for caproic acid production with various substrates. The ethanol-acetate was the most efficient substrate for enriched culture, with 2.7 g/L caproic acid and a yield of 47%. Clostridium strain M1NH was isolated from enriched culture and identified as a gram-positive, rod-shaped, spore-forming with 92% similarity of 16S rRNA to Clostridium kluyveri. Clostridium M1NH has an optimal pH and temperature of 6-6.5 and 35–40°C with a growth rate of 0.11–0.14 h-1, suggesting that the strain was thermotolerant. Clostridium strain M1NH displays the highest caproic acid production of 3.2–3.5 g/L at a pH of 6.5, a temperature of 35–40°C, and an ethanol-acetate molarity ratio of 4:1. Clostridium strain M1NH is tolerant to concentrations of ethanol, acetate, and caproic acid of 5%, 5%, and 2%, respectively. The thermotolerant Clostridium M1NH presents a significant advancement in harnessing sustainable biobased production processes, holding great promise for applications in thermotolerant fermentation.
Studying the prevalnce, habits and outcomes of using contact lenses among students in the Syrian Private University
Authors: Habal Sedra Al , Helwani Omar Al , Haddeh Yusra 
Published: November 2023

Abstract
Background: The lack of sufficient research on wearing contact lenses, and the most common symptoms and complications that lens wearers complain about in the Arab world, and Syria in particular, despite their widespread use, is what prompted us to conduct this study.
Methods: A cross-sectional study, conducted on students at the Syrian Private University. Data was collected between 10/27/2022 and 4/7/2023, and we obtained 1,750 responses. After including only students who are still studying at the university and who wear contact lenses, we arrived at a sample of 500 students.
Results: The study included 500 students. Females constituted most of the study sample (89%), compared to males (11%). The average age of the students was 22.41 years. Nonsmoking students constituted the largest percentage (43%), and most students reported that they did not work (81%). Human medicine students constituted the largest percentage of participating colleges (26%). More than half of students (65%) use lenses without a doctor's prescription. Most students wear lenses with both eyes (98%), compared to 2% who wear them with only one eye. The largest percentage of people wearing contact lenses was cosmetic (44%). Type of contact lenses used; the largest percentage was for flexible lenses (57%). The most common symptoms are dry eyes (58%), redness of the conjunctiva (36%), puffiness of the eyelids (20%), white purulent discharge (17%), and finally sticking of the eyelids when waking up from sleep (13%).
Incommensurate to normal phase transition in malayaite
Authors: Malcherek Thomas , Fischer Michael , Mihailova Boriana , Paulenz Bianca , Paulmann Carsten , Bismayer Ulrich 
Published: November 2023

Abstract
We report variable temperature X-ray diffraction (20 K &lt; T &lt; 295 K) and Raman scattering (90 K &lt; T &lt; 400 K) data of malayaite, the tin analog of the mineral titanite, aided by results from density functional perturbation theory. The phase transition from the normal to the incommensurately modulated crystal structure occurs at Tc = 50 ± 2 K with an almost constant q-vector of 0.27b*. Some first order satellite diffraction maxima are observable up to 55 K, where they increasingly broaden toward the main reflections. Softening of the lowest frequency transverse optical Bg phonon mode, dominated by antiparallel motion of Ca atoms, is observed on cooling from 400 to 90 K. This confirms the displacive character of the transition to the modulated structure, indicated by the instability of this phonon mode in the zero-temperature approximation of first principle computation. The transition to the incommensurately modulated phase is preceded by a temperature region of anomalous thermal expansion in the normal phase, marked by negative thermal expansion along [010] and consequently a change from hardening to softening phonon modes on cooling below 150 K. The modulated phase of malayaite highlights the potential of density functional perturbation theory for the discovery of hitherto unknown ground state structures of minerals.
Patient Characteristics Associated With Phone and Video Visits at a Tele-Urgent Care Center During the Initial COVID-19 Response: Cross-Sectional Study
Authors: Khairat Saif , John Roshan , Pillai Malvika , McDaniel Philip , Edson Barbara 
Published: November 2023

Background
Health systems rapidly adopted telemedicine as an alternative health care delivery modality in response to the COVID-19 pandemic. Demographic factors, such as age and gender, may play a role in patients’ choice of a phone or video visit. However, it is unknown whether there are differences in utilization between phone and video visits.

Objective
This study aimed to investigate patients’ characteristics, patient utilization, and service characteristics of a tele-urgent care clinic during the initial response to the pandemic.

Methods
We conducted a cross-sectional study of urgent care patients using a statewide, on-demand telemedicine clinic with board-certified physicians during the initial phases of the pandemic. The study data were collected from March 3, 2020, through May 3, 2020.

Results
Of 1803 telemedicine visits, 1278 (70.9%) patients were women, 730 (40.5%) were aged 18 to 34 years, and 1423 (78.9%) were uninsured. There were significant differences between telemedicine modalities and gender (P<.001), age (P<.001), insurance status (P<.001), prescriptions given (P<.001), and wait times (P<.001). Phone visits provided significantly more access to rural areas than video visits (P<.001).

Conclusions
Our findings suggest that offering patients a combination of phone and video options provided additional flexibility for various patient subgroups, particularly patients living in rural regions with limited internet bandwidth. Differences in utilization were significant based on patient gender, age, and insurance status. We also found differences in prescription administration between phone and video visits that require additional investigation.
Analítica de negocio desde la oficina de gestión de proyectos
Authors: Vázquez Padilla Díaz Areli 
Published: November 2023

En un mercado dinámico y competitivo y una sociedad cada vez más tecnológica, los datos se consideran uno de los activos más importantes a nivel mundial para las organizaciones, son los impulsores de los negocios en estos días y la base de casi todas las decisiones importantes. En nuestro entorno universitario será importante tomar conciencia de las actividades necesarias para analizar datos a niveles operativos, es por ello que se describe una iniciativa interna para la obtención de éstos en proyectos de un área de la Dirección General de Cómputo y Tecnologías de Información y Comunicación, la Dirección de Colaboración y Vinculación. Para ello, la iniciativa fue gestionada y documentada en el marco de la Guía PMBOK, conocimientos de indicadores para el sistema de gestión de calidad basado en la norma ISO 9001:2015, análisis de datos y analítica de negocio. Entre las principales aportaciones se encuentra la relevancia de la gestión de alcance, tiempo, conocimientos y recursos. Se plantea como posible línea de acción para implantar una cultura de datos, la adopción del concepto de las oficinas de gestión de proyectos en la Universidad así como la necesidad de un gobierno de datos institucional.
Determinants of Consumers’ Willingness to Purchase Generic Medicines
Authors: Dzulkipli Mohd Redhuan , Maon Siti Noorsuriani , Muhamad Yunus Nor Sara Nadia , Jamal Aziz , Nordin Nor Azzura 
Published: November 2023

In Malaysia healthcare costs have posed challenges to the sustainability of the country's dual healthcare system, it is crucial to learn about the factors influencing consumer preferences for generic medicines. The public healthcare system predominantly uses generic drugs, private healthcare providers often prescribe originator brands to their patients. This practice places financial burdens on patients who must fund their medication independently or through private medical insurance. Therefore, the main objective of this paper is to investigate the determinants affecting consumers' willingness to purchase generic medicine in Malaysia. Using convenience sampling, a total of 436 responses was obtained. Descriptive statistics and bivariate logistic regression analysis were employed to examine the influence of sociodemographic factors and individual knowledge on the willingness to purchase generic medicine. The results indicate that age, ethnicity, marital status, education level, household size and income significantly influence the consumers' willingness to purchase generic medicine. Notably, higher education levels and greater income were associated with a higher willingness to opt for generic medicine. Unexpectedly, variables measured by the Theory of Planned Behavior did not contribute substantially to the findings of this study. Nonetheless, individual knowledge was revealed as a significant determinant. To increase the uptake of generic medicines, this study recommends educational programs for both healthcare providers and patients, emphasizing the benefits and safety of generic medicine. This research contributes to the broader discussion on cost-effective healthcare solutions and informs policymakers and healthcare stakeholders in Malaysia.
Oral Microbiome and Multiple Sclerosis? A Novel Concept!
Authors: Esmaeili Sasan , Esmaeili Sara , Zabeti Aram 
Published: November 2023

Human oral microbiota refers to the significant number of microorganisms that exist in the human mouth. It is one of the most intricate microbial populations in the human body. Recent studies have suggested the role of the oral microbiome in diverse nervous system diseases. Consequently, investigating the impact of the oral microbiome in patients with Multiple Sclerosis (MS) could reveal potential associations with the disease. In this review, the role of oral microbiota in MS patients has been addressed. The findings of this study hold promise for future approaches to oral and dental health in patients with Multiple Sclerosis. Also, In the future, oral microbiota may become a new target for uncovering novel approaches to prevent and/or treat MS.
ASSESSMENT OF THE FINANCIAL STABILITY OF ENTERPRISES USING NEURAL NETWORKS
Authors: Kvashuk Oleksandr , Vapriote Ina , Onyskiv Artem 
Published: November 2023

The enterprise is the primary link of the economic system, the stability of which is an important condition for the effective development of the national economy. The sustainability of the enterprise covers a set of factors that allow it to achieve a controlled state of equilibrium and the ability for sustainable economic growth through effective management of activities. The main component of the company's stability is its financial condition, which ensures marketing and personnel stability, promotes the development of production and technical-technological stability, maintains investment stability, and increases the efficiency of the management process. The study describes a neural network-based approach to assessing the financial condition of enterprises, which enables the assessment of the enterprise's financial condition based on its annual financial reports with high accuracy (over 90 percent). The study examined different neural network approaches to analyzing financial data, including the use of different neural network types, training methods, and input parameter selection. The article also examines the influence of various financial indicators on the financial state of the enterprise and suggests using the most significant financial indicators as input parameters for neural networks.
PARASITES OF STRAY CATS IN BAGHDAD AREA
Authors: S. Kadhim F. , K. Jassim F. , H. Kawan M. 
Published: November 2023

In a survey of 26 stray cats collected from different areas in Baghdad. Each cat examined for ectoparasites and gastrointestinal parasites. All cats examined were harbouring one or more species. The high rate of infection was found with Diplopylidium columbae and Physaloptera preputialis (82.6%).
External parasites recorded in this study were Rhipicephalus species and Ctenocephalus felis.
TREATMENT OF CAPRINE DYSTOCIA WITH SPECIAL REFERENCE TO C.S.
Authors: M. AL- Hamedawi T. , J. Khammas D. 
Published: November 2023

Cesarean section (C.S) was performed on 81 out of 172 case of caprine dystocia in local and shami breed goats, aged between 2-4 years old. The animals were brought in by owners and referred to Departmant of Theriogenology, College of Veterinary Medicine, University of Baghdad and another two Veterinary clinic centers around Baghdad during the kidding the kidding seasons of 1990-1993. C.S was a safe method of kid delivery with a high success rate (95%), followed by manual correction and traction (89.4%). The lowest response was obtained by pharmacological treatmant 46.6%. were The most common indications of C.S in does ring womb 45.5%, oversized fetus 35.8%, vaginal prolapse near the end of gestation 16% and fatal monsters 2.4%. C.S was performed more on primiparous does (39.6). Does having male kids appeared to be more likely to require C.S 61.3% than those having female kids 38.7%. rate of kids delivered by C.S was 66.8%. The obtained showed that C.S was most reliable and safe procedure to deal with dystocia in goats.
THE EFFECT OF DIETARY VITAMIN -C- ON THE SEVERITY OF EXPERIMENETAL INFECTIOUS BURSAL DISEASE IN BROILERS
Authors: N. AL- Taweel R. 
Published: November 2023

Fourty chicks were used to study the effect of adding vitamin -C- to the feed on experimental infection with Infectious Bursal Disease (IBD) virus. They were devided randomly into three group. Chicks in group two received 300 mg vitamin C/Kg of food one day befor infection. Chicks in group two and three were infected by giving tissues taken from naturally infected chickens while chicks in group one served
as uninfected untreated controls. The number of infected chicks were zero, 2 and 6 in group one, two and three respectively. Vitamin -C- leveles were reduced from 29.5 to 17.5 mg/100 g. of liver tissues but it rose to 19.3 in infected chickens when vitamin -C- was added. in response to stress of infection heterophils/ lymphocytes ratios was elevated form 0.5 to 0.9 but it reached 0.5 when vitamin -C- was added. The results of this experiment indecated that the severity of IBD can be reduced by adding 300 mg/Kg of vitamin -C- to the feed of broiler chicks.
P PEMETAAN PARTISIPATIF KEPEMILIKAN LAHAN BERDASARKAN SOA DALAM PENGELOLAAN KELOMPOK HUTAN LINDUNG GUNUNG SIRIMAU, KOTA AMBON, PROVINSI MALUKU
Authors: Parera Evelin 
Published: November 2023

ABSTRAK

Pemetaan wilayah adat di sekitar Kelompok Hutan Lindung Gunung Sirimau belum dilakukan sehingga dalam kegiatan pengabdian masyarakat dilakukan pemetaan partisipatif untuk memetakan lahan yang diklaim masyarakat adat sekitar Kelompok Hutan Lindung Gunung Sirimau sebagai hak ulayat yang dimiliki kelompok marga dalam bentuk Soa. Tujuan dari pemetaan kepemilikan lahan yang berbasis parsipatif adalah menciptakan pemahaman yang lebih baik tentang kepemilikan lahan, menghasilkan data yang akurat, dan melibatkan masyarakat setempat serta pemangku kepentingan dalam pengambilan keputusan terkait penggunaan lahan. Metode kegiatan yang digunakan adalah metode partisipatif. Metode analisis yang digunakan adalah metode analisis deskriptif. Pemetaan kepemilikan tanah adat mempunyai sejumlah manfaat, antara lain: Peta dapat memberikan bukti yang jelas mengenai kepemilikan tanah oleh masyarakat adat, sehingga dapat digunakan sebagai alat pembuktian kepemilikan tanah yang efektif. Peta hasil pemetaan partisipatif bisa digunakan sebagai media negosiasi dengan pihak lain, karena dengan peta tersebut menjadi jelaslah bagaimana wilayah itu dimanfaatkan oleh masyarakat dan siapa saja yang berhak atas wilayah itu.

ABSTRACT

Mapping of customary areas around the Mount Sirimau Protected Forest Group has not been carried out so that in community service activities participatory mapping is carried out to map the land claimed by indigenous peoples around the Mount Sirimau Protected Forest Group as customary rights owned by clan groups in the form of Soa. The aim of participatory land ownership mapping is to create a better understanding of land ownership, produce accurate data, and involve local communities and stakeholders in decision making regarding land use. The activity method used is a participatory method. The analytical method used is the descriptive analysis method. Mapping customary land ownership has a number of benefits, including: Maps can provide clear evidence of land ownership by customary communities, so they can be used as an effective means of proving land ownership. Maps resulting from participatory mapping can be used as a medium for negotiations with other parties, because with these maps it becomes clear how the area is used by the community and who has the rights to that area.