bluuebunny/crossref_metadata_2025_split huggingface dataset:
Successful management of refractory immune‐mediated thrombotic thrombocytopenic purpura during pregnancy and delivery using the anti‐VWF nanobody caplacizumab
Authors: Schimmer Roman R. , Sutter Tabea , Bachofner Adrian , Ranieri Elisabetta , Rodewald Ann‐Kathrin , Kremer Hovinga Johanna A. , Kimmich Nina , Trinchero Alice , Studt Jan‐Dirk 
Published: January 2024

SummaryPregnancy is a potential trigger of acute thrombotic thrombocytopenic purpura (TTP). The management of pregnancy‐associated immune‐mediated TTP (iTTP) can be challenging, especially when it is refractory to standard treatment. Caplacizumab, a nanobody to von Willebrand factor (VWF) blocking its A1 domain, is a valuable new therapeutic option. Its use is, however, not approved during pregnancy and breastfeeding. We describe the successful off‐label administration of caplacizumab during pregnancy and delivery in a patient with refractory iTTP. The favourable outcome without significant thrombotic or haemorrhagic complications indicates that caplacizumab may be an effective and safe treatment option in refractory iTTP during pregnancy.
Human aggression in everyday life: An empirical test of the general aggression model
Authors: Kersten Riccarda , Greitemeyer Tobias 
Published: January 2024

AbstractWith the general aggression model (GAM), Anderson and Bushman (2002) provided an integrative framework to explain the complex nature of aggression. Based on the GAM, we examined whether personological and situational factors (interactively) have an impact on the person's internal state (consisting of aggressive cognition, affect, and physiological arousal), which in turn is assumed to lead to aggressive behaviour. In a large‐scale experience sampling study, 403 participants answered 7558 questionnaires over a period of 2 weeks. As hypothesized, participants were more likely to exhibit an aggressive internal state the higher they scored on antagonistic personality traits (trait aggression, narcissism, psychopathy, sadism, anger rumination) and the more interpersonal, intrapersonal, and environmental triggers they experienced. Aggressive behaviour was positively related to trait aggression, psychopathy, sadism, anger rumination, and all situational triggers. Furthermore, the impact of antagonistic personality traits and situational triggers on aggressive behaviour was considerably reduced when the aggressive internal state was taken into account. Contrary to predictions, the relationship between antagonistic personality traits and the aggressive internal state was most pronounced when situational triggers were low. Overall, however, the process by which personal and situational variables predict aggression in daily life can be well explained by the GAM.
Anaphylaxis mortality in the perioperative setting: Epidemiology, elicitors, risk factors and knowledge gaps
Authors: Pouessel Guillaume , Tacquard Charles , Tanno Luciana Kase , Mertes Paul Michel , Lezmi Guillaume 
Published: January 2024

AbstractPerioperative anaphylaxis (PA) is a severe condition that can be fatal, but data on PA mortality are scarce. The aim of this article is to review the epidemiology, elicitors and risk factors for PA mortality and identify knowledge gaps and areas for improvement regarding the management of severe PA. PA affects about 100 cases per million procedures. Mortality is rare, estimated at 3 to 5 cases per million procedures, but the PA mortality rate is higher than for other anaphylaxis aetiologies, at 1.4% to 4.8%. However, the data are incomplete. Published data mention neuromuscular blocking agents and antibiotics, mainly penicillin and cefazolin, as the main causes of fatal PA. Reported risk factors for fatal PA vary in different countries. Most frequently occurring comorbidities are obesity, male gender, cardiovascular diseases and ongoing treatment with beta‐blockers. However, there are no clues about how these factors interact and the impact of individual risk factors. The pathophysiology of fatal PA is still not completely known. Genetic factors such as deficiency in PAF‐acetyl hydrolase and hereditary alpha‐tryptasemia, have been reported as modulators of severe anaphylaxis and possible targets for specific treatments. Our review underlines unmet needs in the field of fatal PA. Although we confirmed the need for timely administration of an adequate dose of adrenaline and the proper infusion of fluids, there is no evidence‐based data on the proper dose of intravenous titrated adrenaline and which clinical manifestations would flag the need for fluid therapy. There are no large clinical studies supporting the administration of alternative vasopressors, such as glucagon and methylene blue. Further research on pathophysiological mechanisms of PA and its severity may address these issues and help clinicians to define new therapeutic approaches.
Evaluation of measurement errors in the Patient‐Oriented Eczema Measure (POEM) outcome
Authors: Duverdier Ariane , Hurault Guillem , Thomas Kim S. , Custovic Adnan , Tanaka Reiko J. 
Published: January 2024

AbstractBackgroundThe Patient‐Oriented Eczema Measure (POEM) is the recommended core outcome instrument for atopic dermatitis (AD) symptoms. POEM is reported by recalling the presence/absence of seven symptoms in the last 7 days.ObjectiveTo evaluate measurement errors in POEM recordings due to imperfect recall.MethodsUsing data from a clinical trial of 247 AD patients aged 12–65 years, we analysed the reported POEM score (r‐POEM) and the POEM derived from the corresponding daily scores for the same seven symptoms without weekly recall (d‐POEM). We quantified recall error by comparing the r‐POEM and d‐POEM for 777 patient‐weeks collected from 207 patients, and estimated two components of recall error: (1) recall bias due to systematic errors in measurements and (2) recall noise due to random errors in measurements, using a bespoke statistical model.ResultsPOEM scores have a relatively low recall bias, but a high recall noise. Recall bias was estimated at 1.2 points lower for the r‐POEM on average than the d‐POEM, with a recall noise of 5.7 points. For example, a patient with a recall‐free POEM of 11 (moderate) could report their POEM score anywhere from 5 to 14 (with 95% probability) because of recall error. Model estimates suggested that patients tend to recall itch and dryness more often than experienced (positive bias of less than 1 day), but less often for the other symptoms (bleeding, cracking, flaking, oozing/weeping and sleep disturbance; negative bias ranging 1–4 days).ConclusionsIn this clinical trial data set, we found that patients tended to slightly underestimate their symptoms when reporting POEM, with significant variation in how well they were able to recall the frequency of their symptoms every time they reported POEM. A large recall noise should be taken into consideration when interpreting POEM scores.
Exploring moral injury among parents with children in out‐of‐home care
Authors: Wissö Therése , Melke Anna , Josephson Irene 
Published: January 2024

AbstractThis article brings together the experiences of parents whose children are placed in out‐of‐home care (OHC) with the theoretical concept of moral injury. The findings are based on empirical data from a research and development project conducted in seven Swedish municipalities with the aim of developing support for such parents. This article draws on a data set of qualitative interviews with 40 parents, 30 mothers and 10 fathers, with children in OHC. The interview transcripts were analysed thematically, with an abductive approach to theories and the empirical data. The findings illustrate how parents of children in OHC experience moral injury in relation to seven aspects: professionals' morally problematic and distressing behaviour, problematic services, an adversarial system, systemic bias, parent's actions, children's withdrawal and feeling excluded. The injuries are related to events in several periods—prior to the child's removal, during the execution of removal and during OHC—and tend to last for many years. These findings stress that the social services must be aware of the injuries parents experience and must minimize the possible harm and moral injury. We also suggest that parents of children in OHC should have an appointed social worker as a means of support.
Influence of sterilization on the retention forces of lithium disilicate and polymer‐infiltrated ceramic‐network crowns bonded to titanium base abutments: An in‐vitro study
Authors: Laforì Andreina , Sailer Irena , Fehmer Vincent , Mojon Philippe , Burkhardt Felix , Pitta João 
Published: January 2024

AbstractObjectivesThe aim of this study was to evaluate the effect of sterilization on the retention forces of lithium disilicate (LD) and polymer‐infiltrated ceramic network (PICN) crowns bonded to titanium base (Ti‐base) abutments.Materials and methodsForty LD and 40 PICN crowns were milled and then bonded to 80 Ti‐bases with two resin composite cements: Multilink Hybrid Abutment (mh) and Panavia V5 (pv) for a total of 8 groups (n = 10). Half of the specimens (test) underwent an autoclaving protocol (pressure 1.1 bar, 121°C, 20.5 min) and the other half not (control). Restorations were screw‐retained to implants, and retention forces (N) were measured with a pull‐off testing machine. The surfaces of the Ti‐bases and the crowns were inspected for the analysis of the integrity of the marginal bonding interface and failure mode. Student's t‐test, chi‐square test, and univariate linear regression model were performed to analyze the data (α = 0.05).ResultsThe mean pull‐off retention forces ranged from 487.7 ± 73.4 N to 742.2 ± 150.3 N. Sterilized groups showed statistically significant overall higher maximum retention forces (p < .05), except for one combination (LD + mh). Sterilization led to an increased presence of marginal gaps and deformities compared to no‐sterilization (p < .001), while no statistically significant relationship was found between failure mode and sterilization (p > .05).ConclusionsSterilization may have a beneficial effect on the retention forces of LD and PICN crowns bonded to titanium base abutments, although it may negatively influence the integrity of the marginal bonding interface.
Fatigue strength of steel–aluminum alloy dissimilar lap joints fabricated by dimple spot welding for automotive application
Authors: Sakaguchi Motoki , Kurokawa Yu , Nakamura Fuminori , Hashimura Toru 
Published: January 2024

AbstractRecently, a new dissimilar mechanical joining method, dimple spot welding (DSW), has been developed for joining steel sheets and aluminum alloys. In this study, tensile shear tests and fatigue tests were conducted on four types of dissimilar lap joints, with two types of steel sheets and two types of Al alloys joined by DSW. Both the tensile shear strength and fatigue strength of DSW joints were found equal to or greater than those of a self‐piercing riveting (SPR) joint. In all four types of DSW joints, fatigue cracks were initiated from the Al alloy and were associated with fretting induced by repeated contact and friction. A finite element analysis showed that the tangential stress was mainly governed by the friction coefficient and also affected by the steel sheet strength. Higher‐strength steel led to lower tangential stress, resulting in a longer fatigue life for the DSW joint.
Acoustic seal deterrents in mitigation of human–wildlife conflicts in the whitefish fishery of the River Iijoki in the northern Baltic Sea area
Authors: Veneranta Lari , Lehtonen Topi K. , Lehtonen Esa , Suuronen Petri 
Published: January 2024

AbstractRecovery of many seal populations has intensified seal‐fishery conflicts. Acoustic deterrent devices (ADDs), designed to deter seals while minimising collateral harm, provide a potential solution. We investigated feasibility of ADDs to protect a European whitefish (Coregonus lavaretus) fishery in the River Iijoki, Finland, which enters the Baltic Sea. A sound barrier produced by a line of ADDs across the river efficiently prevented grey (Halichoerus grypus) and ringed (Pusa hispida) seals from passing the barrier line, thereby increasing catches, decreasing damage to fishing gear and catch and resulting in fewer seal sightings in the area safeguarded by ADDs. Hence, blocking access of seals to a river or its section by ADDs during a critical fishing period is a promising method for reducing seal‐induced catch losses. However, long‐term assessments of impacts of ADDs are still needed to verify the overall effectiveness.
New strategy for the biosynthesis of alternative feed protein: Single‐cell protein production from straw‐based biomass
Authors: Zhang Zherui , Chen Xiaoyi , Gao Le 
Published: January 2024

AbstractWith rapid growth of global population, meeting the increasing demand for food has become a significant challenge. This challenge is further compounded by limited arable land and the necessity to address the nutritional needs of both humans and animals. However, the utilization of straw biomass, which is readily available as an agricultural by‐product, presents a sustainable solution to this problem. Microbial fermentation has emerged as a highly effective method for converting non‐food biomass into protein, particularly known as single‐cell protein (SCP). Compared to traditional protein sources, SCP production through microbial fermentation is rapid and efficient, and requires minimal land resources. This review provides a comprehensive review of the research advancements in SCP from agricultural biomass, including pretreatment methods, microbial strains, and fermentation processes involved in the bioconversion of straw biomass. Due to the complexity of straw‐based biomass (SBB), it is essential to customize industrial strains and optimize the fermentation process to achieve the highest protein yield and productivity. Additionally, improving the compatibility between tailored processes and cost‐effective industrial strains can lead to the production of protein substitutes that are not only highly nutritious but also economically viable. Hence, the application of SCP derived from SBB presents a dual solution by reducing the need for managing agricultural residues and providing a sustainable source of protein. However, the production of SCP from SBB also has some limitations, such as protein‐synthesis efficiency, production cost, and difficulty to scale‐up the production process. In the future, there is great potential for significant advancements in the targeted conversion of SBB into protein by customizing high‐performance microbial strains. Several sensor and machine learning technologies will predict and monitor real‐time dynamic changes in the fermentation process of SBB, offering an opportunity to improve the production of sustainable SCP in an environmentally friendly and precise manner.
What drives low‐income older adults' intention to use mobility applications?
Authors: Chan Diana Yian Lian , Chong Chun Yong , Teh Pei‐Lee , Lee Shaun Wen Huey 
Published: January 2024

AimMobility applications have the potential to support low‐income older adults in facing mobility challenges. However, there is a generally lower uptake of technology in this segment. To understand factors affecting the intention to use a mobility app, we drew upon the Protection Motivation Theory, and tested a model of low‐income older adults' technology adoption.MethodsA cross‐sectional survey was conducted across seven states in Malaysia among community‐dwelling low‐income older adults aged ≥60 years old (n = 282). Measurement items were adapted from pre‐validated scales and 7‐point Likert Scales were used. Partial least squares structural equation modeling was utilized to assess the hypothesized model.ResultsMobility technology awareness was found to shape an individual's threat and coping appraisals associated with their intention to use a mobility app. The decision of a low‐income older adult to adopt a mobility app as a protective action is not a direct function of threat and coping appraisals but is indirect, and mediated by the underlying cost–benefit perceptions of non‐adoption and adoption of the mobility app. In terms of technology perceptions, perceived usefulness is a significant predictor, but not perceived ease of use.ConclusionsThis study entails a new model by uncovering the psychological factors encompassing mobility technology awareness, threat‐coping appraisals, and cost–benefit perceptions on Technology Acceptance Model studies. These insights have important implications for the development and implementation of a mobility app among low‐income older adults. Geriatr Gerontol Int 2024; 24: 342–350.
Sex instead of money: Conceptualizing sexual corruption
Authors: Bjarnegård Elin , Calvo Dolores , Eldén Åsa , Jonsson Sofia , Lundgren Silje 
Published: January 2024

AbstractResearch on the dynamics of corruption has rarely considered sex as a currency in corrupt transactions. This article puts forward the argument that the abuse of entrusted power in exchange for personal gain is relevant also when sex, rather than money, is the currency. It then contributes with a careful conceptualization of such transactions as sexual corruption. Anchoring our conceptualization in the abuse of entrusted power, the article defines sexual corruption, its elements, categories and delimitations, and proposes a conceptual framework that can be used to develop research on sexual corruption. We also address the implications of recognizing sex as a currency in corrupt transactions, providing insights as to why abuse of power is often overlooked when sex is the currency of the transaction. Our approach offers analytic precision and contributes to setting an agenda for the study of sexual corruption as an obstacle to good governance, at a time when efforts to collect data on sexual corruption are increasing.
Moving toward improved immune checkpoint immunotherapy for advanced prostate cancer
Authors: De Velasco Marco A. , Kura Yurie , Fujita Kazutoshi , Uemura Hirotsugu 
Published: January 2024

AbstractHuman prostate cancer is a heterogenous malignancy that responds poorly to immunotherapy targeting immune checkpoints. The immunosuppressive tumor microenvironment that is typical of human prostate cancer has been the main obstacle to these treatments. The effectiveness of these therapies is also hindered by acquired resistance, leading to slow progress in prostate cancer immunotherapy. Results from the highly anticipated late‐stage clinical trials of PD‐1/PD‐L1 immune checkpoint blockade in patients with advanced prostate cancer have highlighted some of the obstacles to immunotherapy. Despite the setbacks, there is much that has been learned about the mechanisms that drive resistance, and new strategies are being developed and tested. Here, we review the status of immune checkpoint blockade and the immunosuppressive tumor microenvironment and discuss factors contributing to innate and adaptive resistance to immune checkpoint blockade within the context of prostate cancer. We then examine current strategies aiming to overcome these challenges as well as prospects.
Ultrafine‐grained WC‐based ceramics prepared via two‐step oscillatory pressure sintering
Authors: Sun Nanjie , Zhu Tianbin , Zhang Yuhang , Cheng Yong , Su Yuqi , Wang Heng , Pan Liping , Li Yawei , Xie Zhipeng , Han Yao 
Published: January 2024

AbstractGrain growth in ceramic‐based composites during sintering has always been an unavoidable problem. Based on the theory of fine‐grained reinforcement, the concept of rapid densification was coupled with the inhibition of grain growth to fabricate ultrafine‐grained WC‐based ceramics. Herein, by combining two‐step sintering with oscillatory pressure sintering (OPS), a new sintering process—two‐step oscillatory pressure sintering (TSOPS), was used for the preparation of ultrafine‐grained WC‐based ceramics. The comparison of the OPS with the TSOPS validated the feasibility of the strategy in achieving homogeneous and fine‐grained microstructures. The optimum mechanical properties of Vickers hardness, fracture toughness, and flexural strength reached up to 29.56 GPa, 7.97 MPa m1/2 and 1591 MPa, respectively. A developed TSOPS process was proposed and proved to dominate the grain size distribution homogenizing, which contributed to the simultaneous enhancement of mechanical properties of the ceramics.
Geographic links and predictable returns
Authors: Jin Zuben , Li Frank Weikai 
Published: January 2024

AbstractUsing establishment‐level data of U.S. public firms, we construct a novel measure of geographic linkage between firms. We show that the returns of geography‐linked firms have strong predictive power for focal firm returns and fundamentals. This effect is distinct from other cross‐firm return predictability and is not easily attributable to risk‐based explanations. It is more pronounced for focal firms that receive lower investor attention, are more costly to arbitrage, and during high sentiment periods. The cross‐firm information spillovers and return predictability are also stronger for geographic peers with economic linkages and with positive information. Our results are broadly consistent with sluggish price adjustment to nuanced geographic information.
Identification and validation of cuproptosis‐related molecular clusters in non‐alcoholic fatty liver disease
Authors: Liu Changxu , Fang Zhihao , Yang Kai , Ji Yanchao , Yu Xiaoxiao , Guo ZiHao , Dong Zhichao , Zhu Tong , Liu Chang 
Published: January 2024

AbstractNon‐alcoholic fatty liver disease (NAFLD) is a major chronic liver disease worldwide. Cuproptosis has recently been reported as a form of cell death that appears to drive the progression of a variety of diseases. This study aimed to explore cuproptosis‐related molecular clusters and construct a prediction model. The gene expression profiles were obtained from the Gene Expression Omnibus (GEO) database. The associations between molecular clusters of cuproptosis‐related genes and immune cell infiltration were investigated using 50 NAFLD samples. Furthermore, cluster‐specific differentially expressed genes were identified by the WGCNA algorithm. External datasets were used to verify and screen feature genes, and nomograms, calibration curves and decision curve analysis (DCA) were performed to verify the performance of the prediction model. Finally, a NAFLD‐diet mouse model was constructed to further verify the predictive analysis, thus providing new insights into the prediction of NAFLD clusters and risks. The role of cuproptosis in the development of non‐alcoholic fatty liver disease and immune cell infiltration was explored. Non‐alcoholic fatty liver disease was divided into two cuproptosis‐related molecular clusters by unsupervised clustering. Three characteristic genes (ENO3, SLC16A1 and LEPR) were selected by machine learning and external data set validation. In addition, the accuracy of the nomogram, calibration curve and decision curve analysis in predicting NAFLD clusters was also verified. Further animal and cell experiments confirmed the difference in their expression in the NAFLD mouse model and Mouse hepatocyte cell line. The present study explored the relationship between non‐alcoholic fatty liver disease and cuproptosis, providing new ideas and targets for individual treatment of the disease.