bluuebunny/crossref_metadata_2025_split huggingface dataset:
Continuity of care and enhanced support for women experiencing antenatal distress: A pilot randomised controlled trial
Authors: John James Rufus , Pickup Wendy , Diaz Antonio Mendoza , Cibralic Sara , Heys Aleisha , Schmied Virginia , Barnett Bryanne , Eapen Valsamma 
Published: November 2023

Abstract
Background
Evidence suggests that enhanced midwifery care may lead to reduction of antenatal distress among pregnant women. Nevertheless, the access/uptake and outcomes for expectant mothers from culturally and linguistically diverse (CALD) backgrounds may be limited. Therefore, this study investigated the effects of enhanced midwifery care in reducing antenatal distress among pregnant women presenting with elevated but sub-clinical symptoms of depression in an ethnically diverse, socio-economically, and geographically disadvantaged area in the South Western Sydney Local Health District (SWSLHD).
Methods
A multisite, single-blinded, randomised controlled trial was conducted with a follow-up period of 6 months. Participants included pregnant women attending the Fairfield and/or Liverpool Antenatal clinic with an Edinburgh Depression Scale (EPDS) score of 10–12 and a psychosocial assessment during the first antenatal visit. Participants were randomly allocated to either the intervention group or usual care group. The enhanced midwifery care was led by a dedicated Research Midwife (RM) that provided care coordination/navigation and social care support from pregnancy to the early postnatal period whereas the usual care group received routine antenatal care. Primary outcomes included reduction in mental ill-health symptoms assessed via EPDS and Kessler’s Psychological distress (K10) assessments whereas secondary outcomes included improvement in parenting confidence (Karitane Parenting Confidence Scale (KPCS)). Linear mixed-effects model was used to examine the effects of treatment on outcomes. Fixed-effects such as time, treatment, and time-by-group interactions were also assessed separately for each outcome variable whilst adjusting for confounders.
Results
37 mothers were recruited into the study, 18 were randomised to the intervention group and 19 to the usual care group. Findings of the mixed-effects model showed significant within group differences in EPDS scores as indicated by the significant effect of time but no significant effect of treatment. Further, there were no significant effects of time, treatment, or significant interactions between time and treatment group for K10 and KPCS.
Conclusion
Findings showed non-significant improvements in antenatal distress and parenting confidence among expectant mothers in the enhanced midwifery care model group compared to usual care. Larger and appropriately powered trials are needed to determine whether small differences in care can reach statistical and clinical significance.
Trial registration:
Australian New Zealand Clinical Trials Registry (ACTRN12623000698673).
MODIS-NDVI (2001-2020) response to natural factors and engineering activities along railway in Sichuan-Tibet Region
Authors: Zhang Jingxiao , Zhang Ruixue , Sun Shao-qi , Pablo Ballesteros-Pérez 
Published: November 2023

Abstract
The ecological environment of Sichuan-Tibet region is sensitive and fragile, the impact of railway construction on its ecological environment cannot be ignored. This research used the NDVI, a theoretical model of spatial-temporal pattern evolution of vegetation cover along the railway and its driving factors was innovatively proposed by integrating Geodetector and other methods. And the model was applied to an empirical study of the vegetation coverage along the major railway projects in Sichuan-Tibet region from 2001 to 2020, based on the MODIS-NDVI dataset. The results showed that: (1) There is significant spatial heterogeneity in the response of vegetation dynamics to natural and anthropogenic factors along the railway. (2) There are two-factor and nonlinear enhancement interaction of the driving factors on vegetation cover, and the interaction effect is greater than the independent effect. (3) Human activities can not only negatively affect vegetation growth and lead to vegetation degradation, but also positively promote vegetation restoration. The general theoretical model proposed in this study not only provides data support for ecological environment monitoring and restoration in Sichuan-Tibet area and areas with similar geographical characteristics, but also provides theoretical support for the study of vegetation dynamic change along major international railway projects.
Systemic lupus erythematosus combined with Wilson’s disease: A case report and literature review
Authors: Yang Zhenle , Li Qian , Liu Suwen , Zong Zihan , Yu Lichun , Sun Shuzhen 
Published: November 2023

Abstract

Background Systemic lupus erythematosus (SLE) and Wilson’s disease (WD) are both systemic diseases that can affect multiple organs in the body. The coexistence of SLE and WD is encountered rarely in clinical practice, making it challenging to diagnose. Case report We present the case of a 9-year-old girl who initially presented with proteinuria, haematuria, pancytopenia, hypocomplementemia, and positivity for multiple autoantibodies. She was diagnosed with SLE, and her blood biochemistry showed elevated liver enzymes at the time of diagnosis. Despite effective control of her symptoms, her liver enzymes remained elevated during regular follow-up. Laboratory tests revealed decreased serum copper and ceruloplasmin levels, along with elevated urinary copper. Liver biopsy demonstrated chronic active hepatitis, moderate inflammation, moderate-severe fibrosis, and a local cirrhosis trend. Genetic sequencing revealed compound heterozygous mutations in the ATP7B gene, confirming the diagnosis of SLE with WD. The girl received treatment with a high-zinc/low-copper diet, but her liver function did not improve. Upon recommendation following multidisciplinary consultation, she underwent liver transplantation. Unfortunately, she passed away on the fourth day after the surgery. Conclusions SLE and WD are diseases that involve multiple systems and organs in the body, and SLE complicated with WD is encountered rarely in the clinic, so it is easy to misdiagnose. Because penicillamine can induce lupus, it is not recommended. Liver transplantation is indicated for patients with liver disease who do not respond to medical treatment with WD. However, further research is needed to determine the optimal timing of liver transplantation for patients with SLE complicated with WD.
Quantitative Assessment of Future Land Use Changes' Impact on Flood Risk Components: Integration of Remote Sensing, Machine Learning, and Hydraulic Modeling
Authors: Gholami Farinaz , Li Yue , Zhang Junlong , Nemati Alireza 
Published: November 2023

Abstract
Flood is one of the most devastating natural hazards that has intensified due to land use land cover (LULC) changes in recent years. Flood risk assessment is crucial task for disaster management activities in flood-prone areas. In this study, we proposed a flood risk assessment framework that combines flood vulnerability, hazard, and damages under long-term LULC changes in the Tajan watershed, northern Iran. The research analyzed historical land use change trends and predicted changes up to 2040 by employing GIS, remote sensing, and land change modeling. The flood vulnerability map was generated using the Random Forest model, incorporating historical data from 332 flooded locations and 12 geophysical and anthropogenic flood factors under LULC change scenarios. The potential flood damage costs in residential and agricultural areas, considering long-term LULC changes, were calculated using the HEC-RAS hydraulic model and a global damage function. Results revealed that unplanned urban growth, agricultural expansion, and deforestation near the river downstream amplify flood risk in 2040. High and very high flood vulnerability areas would increase by 43% in 2040 due to human activities and LULC changes. Estimated annual flood damage for agriculture and built-up areas was projected to surge from $162 million to $376 million and $91 million to $220 million, respectively, considering 2021 and 2040 land use change scenarios in the flood-prone region. The research highlights the importance of land use planning in mitigating flood-associated risks, both in the studied area and other flood-prone regions.
Data Imbalance in Cardiac Health Diagnostics Using CECG-GAN
Authors: Yang Yang , Lan Tianyu , Wang Yang , Cao Ziyue , Li Fengtian , Gao Fei , Wang DianLi , Zhang Zhijun , Chen Xing 
Published: November 2023

Abstract
Heart disease is the world's leading cause of death. Diagnostic models based on electrocardiograms (ECGs) are often limited by the scarcity of high-quality data and issues of data imbalance. To address these challenges, we propose a Conditional Generative Adversarial Network (CECG-GAN). This strategy enables the generation of samples that closely approximate the distribution of ECG data. Additionally, CECG-GAN addresses waveform jitter, slow processing speeds, and dataset imbalance issues through the integration of a Transformer architecture. We evaluated this approach using two datasets: MIT-BIH and CSPC2020. The experimental results demonstrate that CECG-GAN achieves outstanding performance metrics. Notably, the Percentage Root Mean Square Difference (PRD) reached 55.048, indicating a high degree of similarity between generated and actual ECG waveforms. Additionally, the Fréchet Distance (FD) was approximately 1.139, the Root Mean Square Error (RMSE) registered at 0.232, and the Mean Absolute Error (MAE) was recorded at 0.166.
Identification of Cu-N2 sites for Zn-air batteries in harsh electrolytes: from computer virtual screening to practical application
Authors: Li Huanxin , Xu Chenxi , Li Kaiqi , Xu Junwei , Sharma Subash , Zhang Jincan , Mao Boyang , Zhang Hao , Luo Bingcheng , Gong Yi , Yang Kai , Huang Zhongyuan , Wang Jianan , Xi Kai , Fu Chaopeng , Zhao Yunlong , Chai Guoliang , He Guanjie , Parkin Ivan 
Published: November 2023

Abstract
Non-precious-metal catalysts possess promising potential to replace noble metals (e.g. Pt, Ru, Ir etc.) in broad catalytic areas; however the selection of efficient ones based on experimental results is extremely time-consuming and capital sensitive. Herein, we employ a computer-based method for virtual screening (VS) of chemical structures to discover new electrocatalysts via an efficient standard protocol. Specifically, we discovered a thermodynamically stable and highly active Cu-N2 Lewis acid site by combining molecular dynamics (MD) simulation, and density functional theory (DFT) calculations. The MD simulations rapidly screen out the structures that are both thermodynamically stable and stable in harsh electrolytes, while the DFT calculations filter out the ones with high overpotential by evaluating the adsorption energies for oxygen-related adsorption intermediates based on “Volcano plots” theory. The as-predicted Cu-N2 Lewis acid site was experimentally synthesized in a hollow nitrogen-doped octahedron carbon framework (Cu-N2@HNOC), in which an ultra-high loading of single Cu atoms (13.1 wt%, ICP-MS, the highest on record) is achieved. As a result, a flexible solid-state Zn-air battery was fabricated with Cu-N2@HNOC as the cathode catalyst that realized prolonged cycling, achieving a record high maximum power density of 78.1mW/cm2. Our strategy is widely applicable to seek valuable catalysts via VS for a wide range of applications, e.g. electrocatalysis, biocatalysis, and industrial catalysis, and suggests that the VS is more efficient than most experimental approaches.
Spatial and Frequency based Data Hiding Steganography: Performance analysis Utilizing Various Classified Messages
Authors: Sr Tarek , Eltokhy Mostafa , Abouelazm Atef E. , El-Bendary Mohsen A. M. , haggag Ayman 
Published: November 2023

Abstract
The proposed visions for the sixth generation wireless communications network indicate that it will have the ability to transmit massive amounts of data in a very short time. These visions require the sixth-generation network to have a high level of security. This paper focuses on the confidentiality and privacy of data on the sixth-generation wireless communications network. The paper provides a comparison between two techniques of data hiding and showing that may be used with modern security technologies in sixth-generation networks, namely LSBsteganography and SVD watermarking.This comparison between the two technologies is to determine the strength and reliability of each technology in hiding and showing data without affecting it during transmission over the network. This paper provides the comparison by implementing some simulation experiments using these technologies on different types of data such as images, numerical data, and text messages. The simulation results showed the strength and reliability of each technology in hiding and showing data, as well as the impact of each technology on the transmitted data and whether it caused any loss or not.
Study on critical parameters of gob-side entry retaining by roof cutting and pressure relief in inclined coal seams
Authors: Shi Weiping , Li Zhaoying , Liu Changtao , Lv Yanwei , Zhang Haoran , Yang Tao 
Published: November 2023

Abstract
The study explored how to improve gob side entry retaining by roof cutting in inclined coal seams with thick, inclined, and hard roofs. The research focused on optimizing key parameters through theoretical analysis, numerical simulation, and field monitoring at the 1301 headentry of Great Wall No.6 Mine. Firstly, based on the expansion coefficient of rock crushing and masonry beam theory, the theoretical minimum values for the roof-cutting height and angle of the 1301 headentry are derived. Secondly, the theoretical derivation results were further optimized by creating a model of gob side entry retaining using roof cutting in the 1301 working face with the help of PFC2D numerical software. The response characteristics of stress, displacement, and fabric tensor of the roof were compared and analyzed under different roof-cutting heights and angles to enhance the accuracy of the results. The analysis shows a logarithmic relationship between roof-cutting height and pressure relief, where the pressure relief effect decreases as roof-cutting height increases. There is an "S" relationship between the roof-cutting angle and the pressure relief effect; as roof-cutting height increases, the pressure relief effect initially increases and then decreases. The best roof-cutting height and angle for gob side entry retaining in the 1301 headentry of No.6 Great Wall Mine are 13m and 10°, respectively, according to theoretical analysis and numerical simulation. The field monitoring shows that the control effect of surrounding rock under the parameters of roof cutting is good. The deformation of the rock surrounding the retaining roadway is significantly reduced, which effectively meets the mining requirements of the next working face. This verifies the effectiveness of the optimized roof-cutting parameters and provides a theoretical basis and practical reference for selecting parameters for gob side entry retaining through roof cutting in similar conditions.
EBV-associated epigenetic signature in a colorectal cancer multicase family.
Authors: Hamad Reem , Yousif Ommniyah , Idris Razaz , Yousif Rayan S , Kamal Bidour , Ammar Lamees , Ibrahim Tomader A. , Sultan Ali A. , Suleiman Suleiman H. , Ibrahim Muntasir 
Published: November 2023

Abstract
Background: EBV is the first culprit virus that has been linked to human cancers. It has been shown recently to act through various epigenetic mechanisms, including DNA hypermethylation, EBV-related miRNA, and RNA editing enzymes.
Methods: Whole exome sequencing of an extended multi-case colorectal cancer family revealed a potential oncogenic viral etiology. Investigation of such putative involvement in the same family was carried out by interrogating exome sequences of the tumor tissue for the presence of EBV signatures, in addition to immune histochemistry analysis and PCR of the LMP and EBER genes. Due to previously encountered strong signals for the involvement of APOBEC3b as an RNA editing enzyme, quantitative PCR was performed to quantify APOBEC3b. Various bioinformatics tools have also been used to detect virus-related miRNAs.
Results: The EBV 2 sequence was retrieved from patient tumor sequences and detected by PCR and immunohistochemistry in the tumor samples. APOBEC3b was found to be sixfold higher in the sample than in controls, which explains the high C/T transition occurrence among tumor sequences. Bioinformatic analysis revealed that has-miR-29 b and has-miR-130 were among the top related miRNAs to EBV and colorectal cancer which was further supported by expression analysis.
Conclusions: These results, in addition to expanding the list of EBV-related cancers, highlight potential epigenetic mechanisms that might help explain the oncogenic functionality of the virus and the ontology of tumor complexity.
Enhancement of complement-dependent cytotoxicity by linking factor-H derived SCRs 19-20 to CD20 antibodies
Authors: Stoiber Heribert , Prantl Lena , Heider Philipp , Bergmeister Lisa , Bohn Jan-Paul , Wolf Dominik , Banki Zoltan , Bosch Andreas , Plach Maximilian , Huber Georg , Schroedel Silke , Thirion Christian 
Published: November 2023

Abstract
Antibody-mediated complement-dependent cytotoxicity (CDC) on malignant cells is regulated by several complement regulating proteins (CRP), including the inhibitory complement factor H (fH). FH consists of 20 short consensus repeat elements (SCRs) with specific functional domains. Previous research revealed that the fH-derived SCRs 19–20 (SCR1920) can displace full-length fH on the surface of chronic lymphocytic leukemia (CLL) cells, which sensitizes CLL cells for e.g. CD20-targeting therapeutic monoclonal antibody (mAb) induced CDC. Therefore, we constructed lentiviral vectors for the generation of cell lines that stably produce mAb-SCR-fusion variants starting from the approved parental mAbs Rituximab, Obinutuzumab and Ofatumumab, respectively. Flow-cytometry revealed that the modification of the mAbs by the SCRs does not impair the binding to CD20. Increased in vitro lysis potency compared to their parental mAbs was corroborated by showing specific and dose dependent target cell elimination by CDC when compared to their parental mAbs. Lysis of CLL cells was not affected by the depletion of NK cells, suggesting that antibody-dependent cellular cytotoxicity plays a minor role in this context. Overall, this study emphasizes the crucial role of CDC in the elimination of CLL cells by mAbs and introduces a novel approach for enhancing CDC by directly fusing fH SCR1920 with mAbs.
Prevalence of Anemia and its associated factors among 6- 59 months age Children visiting Public Hospitals at Afar Region, Northeast Ethiopia: A Hospital-based cross-sectional study
Authors: Hailu Molla , Wudu Muluken , Gebriye Dagne , Birhanu Tarikua , Bekalu yemane 
Published: November 2023

Abstract

Background
Anemia is a severe global public health problem, especially in developing nations like Ethiopia. The Afar region is notable for its regular droughts, pastoral populations, and lack of safe drinking water. Despite its significance, no study on childhood anemia has been conducted, notably in the Afar Region. The aim of this study was to determine the prevalence of anemia and its associated factors among 6- to 59-month'-old children at Afar Region public hospitals in northeastern Ethiopia.
Method
A hospital-based cross-sectional study was employed among 306 6- to 59-month-old children using the systematic random sampling method who visited Afar region public hospitals from February 30 to April 30, 2023. The data entry was done using EpiData version 4.2 and Anthroplus software for anthropometric measurement, respectively. Moreover, data analysis was done through SPSS version 26. Binary logistic regression models were fitted to identify predictors of anemia. A P value ≤ 0.05 was deemed to be statistically significant.
Result
The overall prevalence of anemia among children under the age of five was 46.41% (95% CI: 43.8–48.9%). Of those anemic children, 62 (43.66%), 60 (42.25%), and 60 (14.08%) were mild, moderate, and severely anemic, respectively. Having an illiterate mother (AOR = 7.06, 95% CI = 2.81, 19.30), having the lowest family monthly income (AOR = 5.19, 95% CI = 1.24, 21.75), having a family size greater than five (AOR = 3.76, 95% CI = 2.82, 5.98), being in the age of 24–35 months (AOR = 3.12, 95% CI = 1.47–7.11), being in rural residence (AOR = 6.11, 95% CI = 1.49,8.99), having previous parasite infection diagnosis (AOR = 3.76,95% CI = 2.16,11.31), having early weaning feeding (AOR = 2.51,95% CI = 2.36–6.51), having malaria diagnosis before 3 months (AOR = 3.37,95% CI = 2.16–11.31), and having diarrhea in the last two weeks (AOR = 2.98,95% CI = 1.57–3.81) were important predictors of under-five age group anemia.
Conclusion
Anemia in children under the age of five was classified as severe in the current study and is regarded as a critical public health issue. It implies that more efforts should be made to increase safe water supply, food security, exclusive breastfeeding, deworming, and malaria control operations.
Effects of Bone Morphogenetic Protein-2 on Osteogenic Differentiation of MC3T3-E1 Cells Prepared by Coaxial Electrospinning
Authors: Liu Geng , Chen Chun Xia , Chang Xue , Huang Jin Mei 
Published: November 2023

Abstract
Objective
To examine the effect of bone morphogenetic protein-2 (BMP-2) on osteogenic differentiation of MC3T3-E1 cells prepared by coaxial electrospinning.
Methods
The coaxial electrospinning technique was used to prepare the shell-core electrospun scaffold (PP-B) loaded with BMP-2 protein, which served as the study cluster. In addition, the electrospun scaffold (PP) was prepared with the same shell material and employed as the control cluster. The effects of the two clusters on the osteogenic differentiation of MC3T3-E1 cells were compared.
Results
Compared with the control cluster, no significant differences were observed in the stent diameter and contact angle within the study cluster (P > 0.05). The cumulative release of BMP-2 in vitro increased with time, indicating continuous BMP-2 release from the PP-B stent. In contrast to the complete medium, the alkaline phosphatase (ALP) level under the extract of the PP-B stent was higher, with a significant difference (P < 0.05). After 1, 3, 5, and 7 days of cell culture, an increase in CCK-8 was observed in both clusters, but there was no significant difference in the level change between the two clusters (P > 0.05), indicating that there was no significant toxicity in both clusters of materials. However, ALP activity increased in both clusters after 7 and 14 days of cell culture, and the change was more pronounced in the study cluster than in the control cluster, with a significant difference (P < 0.05).
Conclusion
No remarkable toxicity was observed in the cells for PP and PP-B scaffolds, and BMP-2 was continuously released in vitro by the scaffolds. Furthermore, PP-B scaffolds significantly enhanced the osteogenic differentiation of MC3T3-E1 cells.