bluuebunny/crossref_metadata_2025_split huggingface dataset:
Prognostic Significance of Echocardiographic Characteristics in Patients with Type 2 Myocardial Infarction: comparison with Type 1 Myocardial Infarction
Authors: Hoang T. H. , Maiskov V. V. , Merai I. A. , Safarova A. F. , Kobalava Z. D. 
Published: December 2023

Aim. To outline echocardiographic features and assess their prognostic significance for major cardiovascular adverse events (MACEs) within 12 months in patients with type 2 myocardial infarction (MI), compared to type 1 MI (T1MI).Material and methods. The prospective observational study included 161 MI patients who underwent coronary angiography within 24 hours of admission. Type 2 MI (T2MI) diagnosis aligned with the Fourth Universal Definition. Echocardiography and speckle-tracking echocardiography were performed within 72 hours of hospitalization. MACEs encompassed cardiovascular death, non-fatal MI, non-fatal stroke, and HF-related readmissions. Logistic regression analysis was conducted to evaluate their associations with the outcomes.Results. T2MI were diagnosed in 74 patients (median age, 65 years; males, 55,4%). During follow up, 18 patients for each MI type experienced at least one MACE event. Left ventricular (LV) systolic dysfunction (LV ejection fraction [LVEF] <50%) was observed in 41 (55.4%) T2MI patients, compared with 66 (75.9%) T1MI patients (p=0.014). Median LVEF and global longitudinal strain [GLS] were 47.5% and 13.4%, respectively, for T2MI, compared to 45% and 13.9%, respectively, for T1MI (p=0.032 and p=0.332, respectively). LV diastolic dysfunction [DD] was observed in 56 (75.7%) T2MI and 77 (88.5%) T1MI patients. Grade III was more frequent in T2MI in comparison with T1MI (14.9% vs 1.1%, p=0.001, respectively), whereas grade I was more common in T1MI patients (75.9% vs 43.2%, p=0.004, respectively). Right ventricular (RV) dysfunction was observed more frequent in T2MI patients, compared to those with T2MI (52.7% vs. 35.6%, p=0.025, respectively). In univariate analysis, grade III DD was significantly associated with MACEs in T2MI (odds ratio [OR] 5.1, 95% confidence interval [CI], 1.3–18.5, p=0.017). In multivariate analysis, GLS ≤ 9.6% (OR = 17.3, 95% CI 3.0-99.5, p=0.001), and prior MI (OR = 16.6, 95% CI 1.7–157.6, p=0.015) were significantly associated with a heightened risk of MACEs in T2MI patients.Conclusion. Patients with T2MI had high prevalence of LV and RV dysfunction. Echocardiographic assessments, particularly speckle-tracking echocardiography, hold promise in predicting adverse outcomes for these individuals.
Inhospital outcomes of myocardial infarction in patients receiving direct oral anticoagulants
Authors: Chashchin M. G. , Gorshkov A. Yu. , Drapkina O. M. 
Published: December 2023

Aim. To evaluate the clinical course and inhospital outcomes of myocardial infarction (MI) in patients receiving continuous direct oral anticoagulant (DOAC) therapy.Material and methods. Data from 390 patients treated for MI were included in the analysis. The mean age was 64.1±12.8 years. The majority were men (61,5%; n=240). All patients underwent standard diagnostic and therapeutic procedures according to clinical guidelines, including coronary angiography and percutaneous coronary intervention when indicated. Clinical, anamnestic and laboratory data (including C-reactive protein level, troponin I, coagulation test) were analysed. The inhospital course of MI, mortality and incidence of complications were evaluated.Results. Patients were divided into two groups according to DOAC therapy received. The main group included 41 patients with constant DOAC intake, while the control group consisted of 349 patients not receiving DOAC. Patients aged 65 years and older accounted for 68,3% (n=28) of the main group (p=0,0033), with a high proportion of cerebral circulation disorders and venous thrombosis (p<0,01). Atrial fibrillation was diagnosed in 75,6% (n=31) of patients in the main group (p<0,0001). ST elevation MI (STEMI) was seen in 39,0% (n=16) of cases in the main group and 47,3% (n=165) of cases in the control group (p=0,3161). As a result, 85,4% (n=35) of patients in the main group had a high GRACE-1 risk, compared to 50,4% (n=176) in the control group (p<0,0001). The two groups did not differ significantly in the severity of heart failure (p=0,1549). ST-segment resolution on admission electrocardiogram was observed in 43,8% (n=7) of the main group and 18,1% (n=30) of the control group (p=0,0238). According to coronary involvement severity and the type of antegrade flow in the infarct-related artery, patients in both groups were comparable (p>0,05). Prior DOAC administration had no significant effect on the incidence of gastrointestinal bleeding (odds ratio (OR), 3,96 (95% Confidence Interval (CI) 0,76–20,66)) and mortality (OR 1,47 (95% CI 0,37-5,85)) during hospitalization.Conclusion. Patients with MI who received continuous DOAC therapy had significantly more frequent ST-segment resolution at hospital admission compared with patients who did not receive DOAC. DOAC administration had no significant effect on mortality and incidence of inhospital complications of MI.
Pharmacogenetics and pharmacokinetics of rivaroxaban in patients with atrial fibrillation and chronic kidney disease
Authors: Shatalova N. A. , Sychev D. A. , Mirzaev K. B. , Kochetkov A. I. , Ebzeeva E. Yu. , Dashabylova V. B. , Bochkov P. O. , Tuchkova S. N. , Glagolev S. V. 
Published: December 2023

Aim. To study the possible relationship between polymorphic variants of ABCB1 (rs2032582, rs1045642, rs1128503), CYP3A5 (rs776746), CYP3A4 (rs35599367) and CYP2J2 (rs890293) genes with residual equilibrium concentrations (Cmin,ss) of rivaroxaban in patients with non-valvular atrial fibrillation (AF) and stage 3 and 4 chronic kidney disease (CKD).Material and methods. A total of 123 patients 52 to 97 years old (median age, 82 years) with AF in combination with stage 3 and 4 CKD were included in the study. Each patient underwent a pharmacogenetic and pharmacokinetic study.Results. Cmin,ss and dose-adjusted concentration (Cmin,ss/D) of rivaroxaban were significantly higher in patients with the TT genotype than with the CT genotype of the polymorphic variant rs1045642 of the ABCB1 gene (Сmin,ss 60,5 [36,7;173] ng/ml and 54,8 [23,1;97,3] ng/ml, respectively, р=0,016; Сmin,ss/D 4,06[2,3;8,1] ng/ml/mg and 2,2 [1,1;4,9] ng/ml/mg, р=0,006). In patients with the T allele (CT and TT genotypes), compared with CC genotype carriers, Cmin,ss and Cmin,ss/D were significantly higher (Cmin,ss 60,5 [36,7;173] ng/ml and 45,8 [20,9;82,3] ng/ml, respectively, p=0,029; Cmin,ss/D 4,06 [2,3;8,1] ng/ml/ mg and 2,6 [1,2;4,8] ng/ml/mg, respectively, p=0,014). Also, Cmin,ss and Cmin,ss/D was significantly higher in patients with the TT genotype according to the polymorphic variant rs2032582 of the ABCB1 gene than in patients with the GG genotype (p=0,02 and р=0,016 respectively). Cmin,ss and Cmin,ss/D in T allele (GT and TT genotypes) carriers were significantly higher than in T allele homozygotes (Cmin,ss 57,1 [27,7;106,0] ng/ml versus 37,6 [18,6;61,7] ng/ml respectively, p=0,024; Cmin,ss/D 3,6 [1,7;7,4] ng/ml/mg versus 2,3 [1,1;4,09] ng/ml/mg respectively, p=0,032). Differences in Сmin,ss and Сmin,ss/D of rivaroxaban were detected when comparing TC, CC and TT genotypes of polymorphism rs1128503 of the ABCB1 gene. When comparing Сmin,ss and Сmin,ss/D of rivaroxaban among carriers of AG and GG genotypes of the rs776746 polymorphism of the CYP3A56986A>G gene, no significance was detected (p>0,05). Also, no difference in Cmin,ss and Cmin,ss/D was found when comparing carriers of the CC and CT genotypes of the rs35599367 polymorphism of the CYP3A4 gene, and carriers of the CC and AC genotypes of the rs890293 polymorphism of the CYP2J2 gene (p>0,05).Conclusion. The carriage of T allele by polymorphic variants rs1045642 and rs2032582 of the ABCB1 gene affects Cmin,ss and Cmin,ss/D of rivaroxaban.
THE EFFECT OF ISLAMIC FINANCIAL DEVELOPMENT AND HUMAN DEVELOPMENT ON INCOME INEQUALITY: DOES ISLAMIC FINANCE KUZNETS CURVE VALID IN THE OIC COUNTRIES?
Authors: Kamalu Kabiru , Wan Ibrahim Wan Hamikah Bint 
Published: December 2023

Income inequality is evident in all countries regardless of the level of development or income status. Islamic financial system has Shariah-compliant financial instruments that, when properly utilized, can facilitate equitable income distribution in the OIC member countries. This study examines the effect of Islamic financial development and human development on income inequality in the OIC. The study also analyzes the validity of the Islamic finance Kuznets curve hypothesis. We employ FMOLS and DOLS estimators with data from 20 OIC member countries covering the period from 2012 to 2022. The results show that Islamic financial development and human development promote equitable income distribution. The findings also confirm the validity of the Islamic finance Kuznets curve hypothesis. Thus, to reduce the income gap in the OIC, Islamic financial institutions should expand further via for examples innovation in Shariah-compliant Islamic financial products and services. In addition, policymakers should prioritize policies and programs that can promote Islamic financing and improve human development in the OIC member countries.
Quantifying a tide-dominated, wave-, and river-influenced delta in Miocene facies of the Niger Delta basin
Authors: Ezeh Sunny C. , Bhattacharya Janok P. 
Published: December 2023

ABSTRACT
The modern Niger Delta has long been classified as a mixed tide-, wave-, and river-influenced delta. Still, no detailed studies have quantified the relative proportions of formative processes and facies. This work presents the first quantitative estimate of the relative influence of formative processes in Miocene deposits based on core data from the Greater Ughelli, Central Swamp, and Coastal Swamp depositional belts of the Niger Delta basin. Facies analysis of 288.2 m of core from four wells shows approximately 53% tidal facies, 33% fluvial facies, and 14% wave-formed facies, indicating deposition in a prograding tide-dominated, wave-, and river-influenced delta.
Cores from the Greater Ughelli and Central Swamp depobelts exhibit coarsening-upwards, prograding deltaic facies successions overlain by fluvial mudstone. Tidal deposits in the Coastal Swamp depobelt show coarsening-upwards prograding deltaic facies successions with well-developed tidal bundles indicating seasonal deposition. The basal part of these facies successions also reveals repeated floods characterized by slump and load structures and dewatering features.
Delta-plain and delta-front–prodeltaic facies associations are identified based on physical sedimentary and biological structures. The delta-plain facies association consists of weakly bioturbated mudstone, fissile mudstone, and coarse-pebbly stratified sandstone facies with sparse trace fossils. The delta-front–prodeltaic facies association contains muddy and sandy heteroliths, stratified, medium and coarse-grained, cross-bedded sandstone, and convoluted mudstone facies. The facies vary but characteristically contain trace-fossil assemblages of the recently proposed Rosselia and Phycosiphon Ichnofacies, indicating delta-front and prodeltaic settings, respectively. Variability in the facies is determined by the relative influence of hydrodynamic processes (tide, wave, and river), variations in physicochemical stress, and the episodic character of deposition. In addition, based on the relative influence of each hydrodynamic processes, the facies differ through the successions, sometimes subtly.
SPE Petroleum Engineering Certification and PE License Exam Reference Guide
Authors: Ghalambor Ali 
Published: December 2023

A one-stop, go-to reference containing all relevant and key industry concepts, equations, terminology, and formulas, the SPE Petroleum Engineering Certification and PE License Exam Reference Guide is the essential tool for those taking the SPE Professional Certification Exam and US PE Exam. This recently updated guide complements SPE’s Petroleum Engineering Handbook series, as the key concepts and equations from that series have been separated out and methodically cataloged into this one volume. To quickly find what you are looking for, a new index has been added.
Along with being crucial before and during exams (YES - IT CAN BE BROUGHT INTO THE EXAM), this invaluable guide continues to serve oil and gas industry professionals throughout their career. With this guide, there is no need to carry a suitcase full of books on every assignment or search multiple texts to simply find a definition or an equation. The SPE Petroleum Engineering Certification and PE License Exam Reference Guide is for anyone searching for an upstream or downstream solution.
The role of provincial health administration in supporting district health management teams in the Democratic Republic of Congo: eliciting an initial programme theory of a realist evaluation
Authors: Samuel Bosongo , Belrhiti Zakaria , Faustin Chenge , Criel Bart , Yves Coppieters , Marchal Bruno 
Published: December 2023

Abstract
Background: In 2006, the Ministry of Health in the Democratic Republic of Congo designed a strategy to strengthen the health system by developing health districts. This strategy included a reform of the provincial health administration to provide effective technical support to District Health Management Teams in terms of leadership and management. The provincial health teams were set up in 2014, but few studies have been done on how, for whom, and under what circumstances their support to the districts works. We report on the development of an initial programme theory that is the first step of a realist evaluation seeking to address this knowledge gap.
Methods: To inform the initial programme theory, we collected data through a scoping review of primary studies on leadership or management capacity building of district health managers in sub-Saharan Africa, a review of policy documents and interviews with the programme designers. We then conducted a two-step data analysis: first, identification of intervention features, context, actors, mechanisms and outcomes through thematic content analysis; and second, formulation of Intervention-Context-Actor-Mechanism-Outcome (ICAMO) configurations using a retroductive approach.
Results: We identified six ICAMO configurations explaining how effective technical support (i.e., personalised, problem-solving centred and reflection-stimulating) may improve the competencies of the members of district health management teams by activating a series of mechanisms (including positively perceived relevance of the support, positively perceived credibility of provincial health administration staff, trust in provincial health administration staff, psychological safety, reflexivity, self-efficacy and perceived autonomy) under specific contextual conditions (including enabling learning environment, integration of vertical programmes, competent public health administration staff, optimal decision space, supportive work conditions, availability of resources, absence of negative political influences).
Conclusion: We identified initial ICAMO configurations that explain how provincial health administration technical support for district health management teams is expected to work, for whom and under what conditions. These ICAMO configurations will be tested in subsequent empirical studies.
Clinical evaluation of deep learning-based risk profiling in breast cancer histopathology and comparison to an established multigene assay
Authors: Robertson Stephanie , Wang Yinxi , Sun Wenwen , Karlsson Emelie , Lövgren Sandy Kang , Acs Balazs , Rantalainen Mattias , Hartman Johan 
Published: December 2023

Abstract
A significant proportion of oestrogen receptor (ER)-positive and human epidermal growth factor receptor 2 (HER2)-negative early breast cancer patients are categorised as intermediate risk based on classic clinicopathological variables, thus providing limited information to guide treatment decisions. The Prosigna assay is one of the established prognostic multigene assays in clinical practice for risk profiling. Stratipath Breast is a novel deep learning-based image analysis tool that utilises haematoxylin and eosin (HE)-stained histopathological images for risk profiling. In this study, we aimed to evaluate the Stratipath Breast tool for image-based risk profiling and compare it with the Prosigna assay. In a real-world breast cancer case series comprising 234 invasive tumours from patients with early ER+/HER2- breast cancer, clinically intermediate risk and eligible for chemotherapy, clinicopathological data including Prosigna results and corresponding HE-stained tissue slides were retrieved. The digitised HE slides were analysed by Stratipath Breast. Our findings showed that the Stratipath Breast analysis identified 49.6% of the clinically intermediate tumours as low risk and 50.4% as high risk. The Prosigna assay classified 32.5%, 47.0% and 20.5% tumours as low, intermediate and high risk, respectively. Among Prosigna intermediate-risk tumours, 47.3% were stratified as Stratipath low risk and 52.7% as high risk. In addition, 89.7% of Stratipath low-risk cases were classified as Prosigna low/intermediate risk. The overall agreement between the two tests for low-risk and high-risk groups was 71.0%, with a Cohen’s kappa of 0.42. For both risk profiling tests, grade and Ki67 differed significantly between risk groups. In conclusion, for the first time, we here present the results from a clinical evaluation of image-based risk stratification and show a considerable agreement to an established gene expression assay in routine breast pathology. The findings demonstrate that image-based risk profiling may aid in the identification of low-risk patients who could potentially be spared adjuvant chemotherapy.
Analysis of the Thermal Flow Field in the Bearing Cavity of Double-Rotor Cylindrical Roller Bearing with Under-Race Lubrication
Authors: Wei F , Liu hongbin , Gao chuang 
Published: December 2023

Abstract

To solve the problem of high-temperature failure of double-rotor cylindrical roller bearing with under-race lubrication. Fluent meshing, the volume of fluid (VOF) method, and multiple reference frame (MRF) method were used to simulate and analyze the flow field and temperature field in the cavity of a double-rotor cylindrical roller bearing. The effect of the outer race speed on the flow field and temperature field in the bearing cavity was studied when the inner race speed of the bearing was constant. The following conclusions were drawn from the simulation results: (1) When the inner and outer races rotate in the opposite direction, the lubricating oil in the bearing cavity is primarily driven by the rotation of the roller; (2) When the inner and outer races rotate in the same direction, the lubricating oil is mainly driven by the revolution of the roller and the cage, that is, the lubricating oil in the outer race of the bearing is more; (3) The larger the speed difference between the inner and outer races, the higher the friction temperature rise in the bearing cavity; (4) When the outer race rotates, the viscosity temperature rise in the bearing cavity increases, and when the inner and outer races rotate in the same direction, the viscosity temperature rise increases faster; (5) The rotational speed of the cage and roller is the principal factor affecting the viscosity temperature rise of the bearing lubricating oil.
Coherent Photoexcitation of Entangled Triplet Pair States
Authors: Musser Andrew , Kim Juno , Bain David , Ding Vivian , Majumder Kanad , Windemuller Dean , Feng Jiaqi , Wu Jishan , Patil Satish , Anthony John , Kim Woojae 
Published: December 2023

Abstract

Functional properties of organic semiconductors are defined by the interplay between optically bright and dark states. Organic devices require rapid conversion between these bright and dark manifolds for maximum efficiency, and one way to achieve this is through multiexciton generation (S1→1TT). The dark state 1TT is typically generated from bright S1 after optical excitation, however the mechanistic details are hotly debated. We report a new 1TT generation pathway in which it can be coherently photoexcited, without any involvement of bright S1. Using <10 fs transient absorption spectroscopy and pumping sub-resonantly, 1TT is directly generated from the ground state. Applying this method to a range of pentacene dimers and thin films of various aggregation types, we determine the critical material properties that enable this forbidden pathway. Through a strikingly simple technique, this result opens the door for new mechanistic insights into 1TT and other dark states in organic materials.
Progressive damage analysis of composite bolted joints based on continuum damage mechanics
Authors: He Boling 
Published: December 2023

Abstract
Based on continuum damage mechanics, progressive damage analysis of composite bolted joints with ply ratios of [(0o)30%/(±45o)60%/(90o)10%] and [(0o)70%/(±45o)20%/(90o)10%] is investigated in this paper. First of all, a new strength criterion is proposed to evaluate the intralaminar (fiber and matrix) and interlaminar damage initiation of composite materials. Then, an exponential material degradation model is adopted to describe the progressive damage process of composite materials. Finally, a continuum damage mechanics model is developed to predict the progressive damage behavior of composite bolted joints with different ply ratios. The predticted results have a good agreement with the experimental values. It is shown that low ±45o ply ratio induces the shear-out failure mode of composite bolted joints, decreasing the load carrying capacity.
On the asymptotic performance of time-delay and Doppler estimation with a carrier modulated by a band-limited signal
Authors: Bernabeu Joan M. , Ortega Lorenzo , Blais Antoine , Grégoire Yoan , Chaumette Eric 
Published: December 2023

Abstract
Time-delay and Doppler estimation is crucial in various engineering fields, being the estimation of these parameters one of the key initial step in the receiver's operational sequence. Due to its importance, several expressions of the CRB and MLE have been derived over the years. However, in all these previous works, it is assumed the wave transmission process introduces an unknown phase which prevents from estimating both time-delay and transmission phase component. In this contribution we revisit this problem under the condition that there are certain practical problems where the transmission phase can be estimated apart, adding this additional measure to the observation model. Then, we rederive a novel MLE under this condition and we provide closed-form expression of the achievable MSE of time-delay and Doppler estimation in the asymptotic region under the band-limited signal condition. Both expression are validated via Monte Carlo simulations. This analysis uncovers five operational regions, refining existing knowledge and providing valuable insights into time-delay estimation theory