bluuebunny/crossref_metadata_2025_split huggingface dataset:
BNS-Anfälle nach Hirnblutung - Arnica und Phosphorus
Authors: Hadulla Michael , Richter Olaf 
Published: December 2003

ZusammenfassungBericht über ein Kleinkind mit cerebralem Anfallsleiden (BNS und Grand mal) nach massiver postnataler Hirnblutung. Die kleine Patientin kommt wegen manifester Verhaltensauffälligkeiten (Hyperaktivität, Irritabilität, Schlafstörungen) unter antiepileptischer Therapie mit Luminal® (= Phenobarbital) und Vigabatrin (= Sabril). Da bekannt ist, dass Phenobarbital u.a. oben genannte psychische Störungen verursacht, erfolgt der homöopathische Therapieversuch. Die Antiepileptika wurden vorsichtig abgesetzt und gleichzeitig mit Homöopathica - Arnica und Phosphorus - therapiert. Das Verhalten der kleinen Patientin normalisierte sich ebenso wie das vorher hochpathologische EEG, und es traten keine neuen Anfälle auf.
Nasal Glioma and Encephalocele: Diagnosis and Management
Authors: Rahbar Reza , Resto Vicente A. , Robson Caroline D. , Perez‐Atayde Antonio R. , Goumnerova Liliana C. , McGill Trevor J. , Healy Gerald B. 
Published: December 2003

AbstractObjective To review the biology of nasal glioma and encephalocele and to present an algorithm for preoperative evaluation and surgical management.Design Retrospective review and analysis.Setting Tertiary care medical center: 1970 to 2002.Patient Sixteen patients with glioma (n = 10) and encephalocele (n = 6).Outcome Age at the time of presentation, sex, signs and symptoms, imaging findings, surgical approach, pathology, complications, rate of recurrence, and follow‐up were recorded.Results Ten patients presented with nasal glioma with a mean age of 9 months. All patients underwent surgical excision. No complication was encountered with a mean follow‐up of 3.5 years. Six patients presented with encephaloceles with a mean age of 15.5 months. All patients underwent surgical excision. Complications included cerebrospinal fluid leak (n = 1) and epiphora (n = 1). Follow‐up was 1 to 14 years (mean, 4 years).Conclusion Nasal glioma and encephalocele are rare, benign, congenital lesions with a potential for intracranial extension. Evaluation should include a complete rhinologic and neurologic examination. Preoperative imaging with a thin‐cut axial and coronal computed tomography scan and/or multiplanar magnetic resonance imaging is essential. Surgical intervention should be performed soon after diagnosis to alleviate the increased risk of meningitis. A frontal craniotomy approach is recommended if intracranial extension is identified based on preoperative evaluation, followed by an extracranial resection. If there is no evidence of intracranial extension, a conservative extracranial approach is recommended.
Vascularized Radial Forearm Free Tissue Transfer for Lining in Nasal Reconstruction
Authors: Moore Eric J. , Strome Scott A. , Kasperbauer Jan L. , Sherris David A. , Manning Lance A. 
Published: December 2003

AbstractObjectives/Hypothesis Total and near‐total nasal reconstruction requires the surgeon to replace external nasal cover, skeletal support, and internal nasal lining. The successful result must re‐create the form and function of the original nose. In large defects, traditional sources of internal lining may be unavailable. The study describes the recreation of nasal lining in three patients with extensive nasal defects with vascularized radial forearm tissue.Study Design Retrospective review of three patients who underwent nasal reconstruction with radial forearm for internal lining, costal cartilage grafts for skeletal support, and paramedian forehead flap for cover.Methods The charts of three patients who underwent total nasal reconstruction with radial forearm tissue transfer for lining were retrospectively reviewed. The technique was evaluated. The authors present a method for internal lining reconstruction in extensive nasal defects. They discuss the advantages and disadvantages of this method.Results Three patients underwent successful total nasal reconstruction with radial forearm tissue transfer for lining, costal cartilage for skeletal support, and paramedian forehead flap. None of the patients had adequate septal mucosa or nasal subunit skin to support mucosal rotation grafts or epithelial turn‐in flaps. All patients have completed reconstruction and have satisfactory nasal form and function. Loss of the lining flap or graft loss did not occur.Conclusion Vascularized radial forearm tissue supplies ample quantities of skin to recreate nasal lining. The tissue provides excellent support of graft material, and it prevents contracture of the covering flap. Because of its bulk and donor site morbidity, free forearm tissue transfer should not be considered for reconstruction of smaller defects when another lining flap will suffice.
Short‐Term Functional Donor Site Morbidity After Radial Forearm Fasciocutaneous Free Flap Harvest
Authors: Skoner Judith M. , Bascom Daphne A. , Cohen James I. , Andersen Peter E. , Wax Mark K. 
Published: December 2003

AbstractObjectives/Hypothesis The existing literature on postoperative donor extremity function describes a spectrum of morbidity in the long term (>3 mo after surgery). However, the consensus is that there is minimal to no impact of flap harvest on patients' activities of daily living. No previous reports have examined functional donor site morbidity in the early postoperative period; such may affect patients' overall perioperative progress, especially with respect to donor extremity dominance. The authors' objective was to quantify functional morbidity of the donor site in radial forearm fasciocutaneous free flaps during the early postoperative period.Study Design Retrospective case series review.Methods Patient data were obtained from hospital records of 12 consecutive patients who underwent head and neck reconstruction with radial forearm fasciocutaneous free tissue transfer over a 6‐month period at a tertiary academic medical center. Functional results of each patient's donor extremity obtained preoperatively and at 5 to 8 days after surgery were determined by quantifying forearm supination and pronation, wrist flexion and extension, and sharp and dull hand sensations in radial, median, and ulnar nerve distributions.Results Mean patient age was 57 years (age range, 42–71 y). The nondominant extremity was the donor site in 9 of 12 patients. Using the paired two‐tailed t test, statistically significant differences were demonstrated in preoperative versus postoperative forearm supination (P < .032), pronation (P < .006), wrist flexion (P < .000), and wrist extension (P < .000). Three of 12 patients demonstrated diminished sharp sensation in the “anatomical snuffbox” distribution.Conclusion The authors describe statistically significant functional forearm and wrist range‐of‐motion morbidity associated with the harvest of a radial forearm fasciocutaneous free flap in the early postoperative period.
Amyloidosis of the Upper Aerodigestive Tract
Authors: Pribitkin Edmund , Friedman Oren , O'Hara Brian , Cunnane Mary F. , Levi David , Rosen Marc , Keane William M. , Sataloff Robert T. 
Published: December 2003

AbstractObjectives/Hypothesis To delineate the clinical and pathologic characteristics of upper aerodigestive tract amyloidosis with particular attention to laryngeal amyloidosis.Study Design Retrospective chart review of patients with amyloidosis of Thomas Jefferson University and its affiliated hospitals.Material and Methods The charts of 16 patients with upper aerodigestive tract amyloidosis identified from the databases of the Thomas Jefferson University pathology department were reviewed and included in the study.Results Sixteen patients (9 male and 7 female, with an average age of 49.8 years) with upper aerodigestive tract amyloidosis were identified. The most common site of amyloid involvement was the larynx. Consequently, patients most commonly presented with hoarseness (14 of 16). All patients underwent surgical removal of the amyloid deposits. Fourteen patients had primary localized amyloidosis. Two experienced systemic involvement. Seven of the 16 patients developed recurrences requiring further treatment.Conclusions Amyloidosis of the upper aerodigestive tract generally behaves as a benign, localized condition treatable by surgical resection. Regular follow‐up with laryngoscopy is indicated for early diagnosis of recurrence, and multiple surgical procedures may be required to control symptoms.
Actinomycosis Abscess of the Thyroid Gland
Authors: Cevera John J. , Butehorn Henry F. , Shapiro Joel , Setzen Gavin 
Published: December 2003

AbstractObjectives To present an unusual case of actinomycosis abscess of the thyroid gland as well as review the history, etiology, pathogenicity and treatment of actinomycosis infections of the head and neck.Study Design Case study.Methods A report of a 39 year‐old female status post tooth extraction that developed an actinomycosis abscess of the thyroid.Results After a thyroid actinomycosis abscess was suggested by physical exam, ultrasound, CT scan and needle aspiration, an otolaryngology consult was obtained. The patient successfully was managed with thyroidectomy and intravenous ceftriaxone.Conclusions Although Actinomycosis soft tissue infections of the head and neck are relatively uncommon, the head and neck surgeon must include it in the differential diagnosis when clinical presentation raises suspicion. Early biopsy is necessary for appropriate identification of the organism with the appearance of sulfur granules lendign a clue to the diagnosis. Debridement and/or excision are often necessary for antibiotics to be used successfully. Antimicrobial therapy should be used for six to twelve months to completely eradicate the disease and prevent recurrence.
Canal Wall Reconstruction with Mimix Hydroxyapatite Cement: Results in an Animal Model and Case Study
Authors: Dornhoffer John , Simmons Oliver 
Published: December 2003

AbstractObjective/Hypothesis To assess Mimix hydroxyapatite cement for its applicability in canal wall reconstruction using the gerbil as a canal wall model. A case is presented to illustrate a novel technique of canal wall reconstruction using Mimix on the basis of the findings of our animal research.Study Design This was a preclinical study.Methods Ten Mongolian gerbils were implanted with Mimix, with the left side used to simulate mastoid obliteration and the right side used to simulate canal wall reconstruction. Pre‐ and postsurgery auditory‐evoked brainstem responses were used to assess ototoxicity, and hematoxylin‐eosin staining of histologic sections was used to assess inflammatory and foreign‐body response and new bone formation.Results Rapid wound healing was achieved with each of the nine animals evaluated, with no erythema, edema, or drainage. Inspection of the ear canal at the time of sacrifice revealed no signs of otitis media and no middle ear effusions. Microscopic examination showed no inflammatory response or foreign‐body reaction, good mucosalization on the side of the implant facing the bulla, and minimal fibrosis adjacent to the skin. Eight of nine specimens showed new woven bone ingrowth at the bone implant interface, with active osteoblasts and viable lacunae cells. There were no apparent fractures in the implanted material.Conclusions Mimix hydroxyapatite cement is biocompatible and suitable for canal wall reconstruction in the animal model. The characteristics of this cement, namely its ability to set quickly in a moist environment, offer advantages over previously used cements for canal wall reconstruction.
The Effect of GJB2 Allele Variants on Performance After Cochlear Implantation
Authors: Bauer Paul W. , Geers Ann E. , Brenner Christine , Moog Jean S. , H. Smith Richard J. 
Published: December 2003

AbstractObjectives/Hypothesis It has been hypothesized that etiology of hearing loss may serve as an independent variable in performance after cochlear implantation. To test this hypothesis, the authors identified pediatric cochlear implant recipients with gap junction protein β2 (GJB2)–related deafness. The study examines performance outcomes associated with GJB2 deafness‐causing allele variants.Study Design Pediatric cochlear implant patients were screened for GJB2 allele variants; statistical comparisons were made with prospectively obtained performance measures.Methods From 181 children who participated in a nationwide cochlear implant research program, 122 children were identified with congenital nonsyndromic sensorineural hearing loss and invited to participate. Screening for GJB2 allele variants was completed for 55 children. The children were homogeneous with respect to age (8 or 9 y) and age at implant (before age 5 y). All patients have previously undergone a prospective regimented battery of performance measures.Results Performance measures were compared between 22 children with and 33 children without mutations to determine whether GJB2 status was a significant predictor of cochlear implant outcomes. Reading and cognitive outcomes were significantly dependent on connexin status. The group of children who tested positive for GJB2‐related deafness scored significantly higher on a nonverbal cognitive measure, Block Design, and on a measure of reading comprehension.Conclusion The isolated insult to the cochlea created by GJB2 allele variants allows for preservation of central cognitive function. Better reading performance is seen in children with GJB2‐related deafness.
Inner Ear Decompression Sickness and Inner Ear Barotrauma in Recreational Divers: A Long‐Term Follow‐Up
Authors: Shupak Avi , Gil Amnon , Nachum Zohar , Miller Shira , Gordon Carlos R. , Tal Dror 
Published: December 2003

AbstractObjectives/Hypothesis The objectives were to report the authors' experience with the long‐term follow‐up of patients with diving‐related inner ear decompression sickness and inner ear barotrauma and to discuss residual cochlear and vestibular damage in relation to the question of fitness to dive.Study Design Retrospective consecutive case series.Methods Eleven recreational divers with inner ear decompression sickness and nine with inner ear barotrauma (IEB) were followed. A complete otoneurological physical examination and laboratory evaluation were carried out. The latter included audiometry, electronystagmography, a rotatory chair test using the sinusoidal harmonic acceleration protocol, and computerized dynamic posturography.Results Residual cochleovestibular deficits were found in 10 (91%) of the patients with inner ear decompression sickness and 3 (33%) of those with IEB (P < .02, Fisher's Exact test; odds ratio, 20). A significantly shorter follow‐up period was required for the inner ear barotrauma group (P < .05, simple t test) because three patients (33%) recovered completely within 1 month of the diving accident. Eight patients had residual vestibular deficits on follow‐up, but only one (12.5%) was symptomatic. However, five (56%) of the nine patients who had a cochlear insult, as documented by follow‐up audiometry, complained of significant hearing loss and tinnitus.Conclusion Inner ear decompression sickness carries a high risk for residual inner ear damage despite hyperbaric oxygen recompression therapy. A favorable prognosis might be anticipated for inner ear barotrauma. The finding that most patients with residual vestibular deficits were asymptomatic at the time of follow‐up emphasizes the need for a complete vestibular evaluation, including specific bedside testing and laboratory examinations, before a return to diving activity may be considered.
Intralesional Cidofovir and Surgical Excision for Laryngeal Papillomatosis
Authors: Naiman Ana Nusa , Ceruse Philip , Coulombeau Bruno , Froehlich Patrick 
Published: December 2003

AbstractObjective To evaluate the efficacy of cidofovir intralesional therapy in recurrent respiratory papillomatosis and the role of surgical excision as an associated treatment.Study Design Prospective study and case series.Method Twenty‐six patients received intralesional cidofovir. Three endoscopies were performed at monthly intervals, with intralesion injections of cidofovir at 5 mg/mL. Further endoscopic evaluation was made at 3 or 6 months depending on whether there was persistent papillomatosis. Cidofovir was again injected in the case of persistent papillomas, and treatment was repeated as long as papillomas were observed. Surgical excision of the papilloma was only performed in cases of airway obstruction or in cases proving resistant to cidofovir.Results Complete remission was obtained in 8 (31%) patients after an average of 2.6 endoscopic treatment. Seventeen (65%) patients presented slight or mild disease at endpoint (final severity score 1–4). Significant results were obtained in both adults and children. A greater response was obtained in the supraglottis and glottis subsites than in subglottis, tracheal, and other sites. Patients conforming to the 1 month interinjection schedule showed better responses in supraglottis subsite than those receiving their injections with intervals longer than 1 month. Combined therapy (cidofovir plus excision) was necessary in persistent papillomas. No patients presented with any systemic or local side effects.Conclusions Cidofovir therapy was an effective treatment in adults and in children, allowing papillomatosis to be controlled without observed side effects. Surgical excision associated with cidofovir injections remained necessary in persistent papillomatosis after cidofovir treatment.
Voice Rest after Microlaryngoscopy: Current Opinion and Practice
Authors: Behrman Alison , Sulica Lucian 
Published: December 2003

AbstractObjective Although voice rest is often recommended after excision of benign mucosal vocal fold lesions, no standard of care exists regarding the use, duration, or extent of vocal restrictions. This prospective study is intended to explore current opinions and practices of otolaryngologists regarding the use of complete and relative voice rest.Study Design and Methods A 16‐item survey was mailed to all active U.S. members of the American Academy of Otolaryngology‐Head and Neck Surgery (n = 7,321) regarding use of complete and relative voice rest after surgical excision of vocal fold nodules, polyps, and cysts. Treatment preference questions used a Likert 5‐point scale with end anchors of 1 equaling “never” and 5 equaling “always”.Results The response rate was 16.5% (1,208 respondents). Differences by lesion type were not statistically significant, suggesting that surgeons consider the mucosal disruption resulting from the surgery to be similar across lesions. Approximately 51.4% (620) favored complete voice rest. Approximately 62.3% (753) favored relative voice rest. Approximately 18% (213) of the respondents who “always” recommend complete rest also “always” recommend relative rest. The most common duration for both types of rest is 7 days.Conclusions There is a clear preference for the use of voice rest, but the specific type (complete or relative) is controversial, and a notable percentage of respondents (15%) do not favor any type of voice rest. It is likely that the lack of uniformity of opinions and practices reflects the absence of empirical data. Prospective clinical trials are needed to guide clinical standards of care.
Sling operations in the treatment of stress urinary incontinence: How to adjust sling tension
Authors: Mahmoud Ezzat Ibraheem 
Published: December 2003

AbstractAim:  To find an objective method of adjusting sling tension in order to avoid postoperative urinary obstruction.Methods:  Thirty‐five female patients with type II/III and type III stress urinary incontinence were treated using a sling procedure. Pubovaginal fascial slings were implanted in 20 patients and polytetrafluoroethylene patch slings with nylon sutures were implanted in 15 patients. During the procedures the urinary bladder was partially full and the patients, who were under spinal or epidural anesthesia, were asked to cough and strain. The proper tension that effectively prevents urine leakage was selected and the corresponding suture length was marked. An objective new method to adjust sling tension was used. As part of this method, the abdominal bulge index is added to the suture length before tying.Results:  Short‐term follow‐up of 6–12 months showed that 33 of 35 patients reported no leakage of urine (94%). Two patients had unsatisfactory urge incontinence. We did not encounter postoperative urinary retention in any patient. No significant post‐voiding residual urine was reported. None of our patients in this series have complained of difficulties during micturition or the need to strain during voiding.Conclusion:  Proper adjustment of sling tension using the abdominal bulge index has eliminated postoperative urinary retention and obstructed urine flow, including any appreciable amount of post‐voiding residual urine. This method has been found to be both objective and reproducible.
Schistosoma mansoni pseudo‐cyst as a cause of chronic pelvic pain
Authors: Nicolau Sérgio M. , Soares José M. , Schor Eduardo , Gonçalves Wagner J. , De Freitas Vilmon , Baracat Edmund C. 
Published: December 2003

AbstractA case of mansoni schistosomiasis causing peritoneal inflammation and chronic iliac pain is reported. The patient complained of iliac pain for 6 months. Physical examination and sonographic evaluation found a tumor in the left iliac fosse. A pseudocyst was removed from the pelvic region. The histopathology confirmed the diagnosis of S. mansoni. This is a rare case of S. mansoni in the pelvic cavity.
Single dose nasal 17beta‐estradiol administration reduces sympathovagal balance to the heart in postmenopausal women
Authors: Kaya Dayimi , Cevrioglu Serhan , Onrat Ersel , Fenkci Ibrahim V. , Yilmazer Mehmet 
Published: December 2003

AbstractAim:  Long‐term estrogen replacement therapy has favorable results on autonomic cardiovascular functions in postmenopausal women. Although acute estrogen administration has beneficial modulations on autonomic tone in animal studies, there are still controversies about the effects of acute estrogen on autonomic modulation to the heart in humans. The aim of this double‐blind study was to investigate the acute effects of intranasal 17beta‐estradiol administration on autonomic control of heart rate.Methods:  Nineteen postmenopausal women with typical hormone profiles were crossover randomized to 300 µg nasal 17beta‐estradiol (Aerodiol, Servier, Chambray‐les‐Tours, France) or an identical placebo at least 5 days apart. Both time domain and frequency domain heart rate variability (HRV) parameters were obtained during controlled respiration (CR) and handgrip exercise (HGE), before and 45 min after 17beta‐estradiol or placebo administration.Results:  Baseline HRV parameters were similar for each occasion. Time domain indices obtained after 17beta‐estradiol administration were not significantly different from results obtained with the placebo. In frequency domain parameters, 17beta‐estradiol administration resulted in a reduced low frequency to high frequency ratio (LF/HF ratio) when compared with the placebo during CR (0.72 ± 0.09 vs 1.00 ± 0.15, P < 0.05) but not during HGE (3.03 ± 0.37 vs 2.86 ± 0.30, P > 0.05).Conclusion:  A single intranasal 17beta‐estradiol administration acutely reduced sympathovagal balance to the heart during the course of parasympathetic maneuver in healthy postmenopausal women.