bluuebunny/crossref_metadata_2025_split huggingface dataset:
The use of corn hybrid ROSS 195 for silage production in Central Non-Black Earth Region
Authors: Belomozhnov T. D. , Klimenko V. P. , Osipyan B. A. , Vasilyeva E. P. 
Published: November 2023

Relevance. This article presents the results of assessing the biochemical parameters and aerobic stability of silage prepared from the domestic early ripening corn hybrid Ross 195 (FAO 180) in the phase of milky-wax ripeness of the grain. Green mass was carried out during harvesting at Barybino LLC in August 2021.Methods. Ensiling was carried out in laboratory conditions of the Federal Williams Research Center of Forage Production & Agroecology in four variants of treatments with various preservatives in three replications of each.Results. Quality indicators were monitored after 30 and 60 days of conservation. Seven days after opening the containers during outdoor storage in silage variants with the addition of biological inoculants, a slight decrease in the concentration of lactic acid and an increase in acetic acid were determined. In silage with chemical preservative, the acid content remained at the same level. The results of assessing the dynamics of silage heating during outdoor storage allow us to conclude that the aerobic stability of the feed with biological inoculants is sufficient, versus control. At the same time, best preservation (over a period of up to 135 hours) the best aerobic stability of silage was obtained with chemical preservative, which was characterized by higher quality indicators in terms of the level of active acidity (pH 4.0–4.1), ammonia content (0.0055–0.0078%) and sugar, and the quantity and ratio of organic acids remained at the level determined at opening.
The effectiveness of feeding the pancreas of pigs to calves of the weaning period of growing
Authors: Romanov V. N. , Bogolyubova N. V. , Mishurov A. V. , Devyatkin V. A. , Rykov R. A. 
Published: November 2023

Relevance. The study of the physiological effect of the pancreas, which is a slaughter waste, on the body of calves of early weaning during the formation of digestive activity of the gastrointestinal type to improve the adaptive capabilities of the body of calves is of scientific and practical interest.Methods. Scientific and production experience was carried out on calves of the weaning period for 90 days. The pancreas of pigs (pancreas) was fed, obtained from the waste of the slaughterhouse production, dried with the use of lyophilization. Calves – analogs by breed, age, live weight – were formed into two groups (n = 8), the animals of the experimental group were given a feed product at the rate of 40 mg/kg of live weight daily with compound feed with group loose content. Live weight accounting (n = 8) and analysis of biochemical and hematological composition of blood (n = 5) were carried out.Results. Higher live weight gains of calves treated with PHC were established with improvement of biochemical and hematological blood parameters (without negative aftereffect). With a tendency to increase the level of total protein due to the albumin fraction, a lower level of urea is also positive evidence of an improvement in nitrogen metabolism. Higher creatinine levels in combination with glucose and alkaline phosphatase levels characterize an increase in the availability of energy exchange processes in the body of calves under the influence of a feed product. Positive differences in the levels of phospholipids, triglycerides, cholesterol against the background of lower bilirubin levels indicate an improvement in lipid metabolism, but also (indirectly) lipotropic liver function. Positive trends have been established in hematological indicators of blood, higher levels of erythrocytes, hemoglobin, hematocrit, lower levels of leukocytes.
Gestión sostenible para la competitividad del sector de la agroindustria no alimentaria y artesanal en las MIPYMES en Panamá
Authors: Vergara Villarreal Gabriel , Peñalba Vanesa 
Published: November 2023

La investigación plantea la importancia de la gestión sostenible y competitiva y su impacto en los mercados que se encuentran globalizados donde las (TICs) juegan un papel importante y se conjugan con la sociedad de la información y el conocimiento para su desarrollo, en donde la gerencia del siglo XXI debe considerar ambos paradigmas para garantizar una sostenibilidad en la gestión.
Las MIPYMES aportan al crecimiento económico, social y cultural de los países, generan empleo y garantizan ingresos aportando a la productividad, competitividad y distribución de la riqueza de las naciones en proceso de desarrollo [1].
En Panamá, se han desarrollado estudios sobre la competitividad de las MIPYMES del sector de servicios, comercio, etc., esfuerzos del grupo de investigación GEUNES, en conjunto con el CNC. De igual forma se destacan las investigaciones para el sector agroindustrial alimentario, por parte del CEPIA-UTP [2], pero muy pocos estudios al sector agroindustrial no alimentario y artesanal.
El presente proyecto tiene como objetivo, describir las características de la gestión gerencial que permita la sostenibilidad y competitividad de la MIPYMES del sector antes descrito, en Panamá con una revisión bibliográfica.
Primeramente, para el proyecto de investigación, se ha ejecutado una revisión bibliográfica sistémica de artículos científicos en Web of Sciencie, utilizando la herramienta de Rtudio con Bibliometrix. Se obtuvieron búsquedas de artículos científicos. Por otro lado, se ha creado un código QR para poder realizar el levantamiento de una base de datos de MIPYMES, del sector de artesanías, para definir la muestra del estudio.
Cultura investigativa en las universidades panameñas: realidad o ficción
Authors: Miller Norma , Mapp Ulina , Bieberach Rebeca , López-Alfano Omar 
Published: November 2023

La mesa redonda “Cultura investigativa en las universidades panameñas: realidad o ficción” abordó la cuestión de si existe o no una cultura investigativa sólida en las universidades panameñas. Se discutieron temas como la importancia de la investigación en la universidad, los principales obstáculos que impiden el desarrollo de una cultura investigativa sólida, la formación de investigadores, la relación entre la investigación y la docencia, el papel de las políticas públicas y cómo la investigación puede contribuir al progreso social y económico de Panamá.
Esta mesa redonda contribuyó a tener una visión más clara de la situación actual de la investigación en las universidades panameñas y planteó posibles soluciones para mejorar la cultura investigativa en el país. Algunas de las preguntas que se abordaron fueron: ¿Está realmente presente la investigación en la cultura universitaria panameña? ¿Cuáles son los principales obstáculos que impiden el desarrollo de una cultura investigativa sólida y qué se puede hacer para superarlos? ¿Cómo se prepara a los estudiantes para la investigación y cuál es el papel de los docentes en este proceso? ¿Cómo se pueden integrar la investigación y la docencia para fortalecer la cultura investigativa en las universidades panameñas?Los temas científicos que se abordaron incluyeron la importancia de la investigación para el desarrollo social y económico de un país, la formación de investigadores y la integración de la investigación y la docencia. Además, se discutieron las políticas públicas necesarias para fomentar la cultura investigativa en las universidades panameñas.En cuanto a las innovaciones e investigaciones que se mencionaron, los expositores compartieron experiencias y buenas prácticas para mejorar la cultura investigativa en las universidades panameñas. También se presentaron posibles soluciones para mejorar la formación de investigadores y fomentar la investigación como fuente de innovación y desarrollo.
Congreso Nacional de Ciencia y Tecnología – APANAC : Acta de artículos 2023
Authors: Morales Maure Luisa , Zachrisson Salamina Bruno , Sánchez-Galán Javier , Solis Mairim 
Published: November 2023

Este año, el Congreso Nacional de Ciencia y Tecnología APANAC 2023 busca promover la diversidad disciplinaria y crear espacios para que investigadores de diversos campos compartan sus investigaciones e ideas, lo que conducirá a avances significativos en ciencia con impacto social. y las innovaciones resultantes pueden responder a problemas y desafíos nacionales en los campos de la sostenibilidad ambiental, la salud pública, la tecnología, la educación, la economía, la agronomía, las ciencias sociales y la ingeniería. Por ello, la interacción y colaboración entre expertos de distintas disciplinas puede generar conocimientos e innovaciones valiosas para enfrentar los desafíos más apremiantes de nuestra sociedad, y así, contribuir a un futuro más próspero y sostenible para todos los panameños.
Esta edición pone especial énfasis en la participación de los jóvenes, ya que representan el futuro de la investigación y la innovación. Convencidos de su rol transformador, el Gobierno Nacional a través del Consejo de Gabinete elaboró un Plan Estratégico Nacional de Ciencia, Tecnología e Innovación: “HACIA LA TRANSFORMACIÓN DE PANAMÁ” el cual se enmarcó en las metas y objetivos. Este Plan 2019-2024 comprende una estrategia económica y social integrada por cinco pilares estratégicos, el que estamos desarrollando en esta actividad. Por lo que hemos unificado los logos 2018 y 2021 continuando con la convergencia de actores para la discusión en torno a los complejos escenarios que nos presenta el periodo postpandemia para proyectar al país a la quíntuple hélice representando una interacción colectiva, un intercambio de conocimiento científico que incluye cinco subsistemas o hélices: (1) Sistema Educativo; (2) Sistema Económico; (3) Entorno Natural; (4) el Público basado en los medios de comunicación y en la cultura y/o sociedad civil y (5) el sistema político.
Towards sustainable electrochemistry: green synthesis and sintering aid modulations in the development of BaZr0.87Y0.1M0.03O3−δ (M = Mn, Co, and Fe) IT-SOFC electrolytes
Authors: Ain Qurat ul , Irshad Muneeb , Butt Muhammad Salim , Tabish Asif Nadeem , Hanif Muhammad Bilal , Khalid Muhammad Ali , Ghaffar Rabia , Rafique Muhammad , Shawar Kazmi Syeda Dur E. , Siraj Khurram , Hafez Amal A. Abdel , Abd-Rabboh Hisham S. M. , Zmrhalova Zuzana , Filonova Elena A. , Medvedev Dmitry A. , Motola Martin 
Published: November 2023

In this study, BaZr0.87Y0.1M0.03O3−δ perovskite electrolytes with sintering aids (M = Mn, Co, and Fe) were synthesized by a sustainable approach using spinach powder as a chelating agent and then compared with chemically synthesized BaZr0.87Y0.1M0.03O3−δ (M = Mn, Co, and Fe) electrolytes for intermediate temperature SOFCs. This is the first example of such a sustainable synthesis of perovskite materials with sintering aids. Structural analysis revealed the presence of a cubic perovskite structure in BaZr0.87Y0.1M0.03O3−δ (M = Mn, Co, and Fe) samples synthesized by both green and conventional chemical methods. No significant secondary phases were observed in the samples synthesized by a sustainable approach. The observed phenomena of plane shift were because of the disparities between ionic radii of the dopants, impurities, and host materials. The surface morphology analysis revealed a denser microstructure for the electrolytes synthesized via green routes due to metallic impurities in the organic chelating agent. The absence of significant impurities was also observed by compositional analysis, while functional groups were identified through Fourier-transform infrared spectroscopy. Conductivity measurements showed that BaZr0.87Y0.1M0.03O3−δ (M = Mn, Co, and Fe) electrolytes synthesized by oxalic acid have higher conductivities compared to BaZr0.87Y0.1M0.03O3−δ (M = Mn, Co, and Fe) electrolytes synthesized by the green approach. The button cells employing BaZr0.87Y0.1Co0.03O3−δ electrolytes synthesized by the chemical and green routes achieved peak power densities 344 and 271 mW·cm−2 respectively, suggesting that the novel green route can be applied to synthesize SOFC perovskite materials with minimal environmental impact and without significantly compromising cell performance.
Exercise during chemotherapy to prevent breast cancer-related cognitive decline: protocol for a pilot randomized controlled trial
Authors: Salerno Elizabeth A. , Harriss Courtney , Andrade D. Carolina , Peterson Lindsay L. , Duncan Ryan P. , Kepper Maura M. , Luo Jingqin , Creel Patricia , Colditz Graham A. 
Published: November 2023

BackgroundCancer-related cognitive decline (CRCD) is one of the most reported and debilitating symptoms associated with breast cancer treatment with no currently accepted treatment. Physical activity has emerged as a promising solution for maintaining cognitive health after cancer, with research suggesting that earlier intervention may be important for preventing or mitigating CRCD. There is a clear need to pilot the feasibility and efficacy of pragmatic physical activity interventions to promote cognitive health during active breast cancer treatment. The purpose of this study is to pilot test a home-based prehabilitation physical activity intervention aimed at preventing cognitive decline during chemotherapy, as well as assess the feasibility, acceptability and appropriateness of the intervention among patients.MethodsThis study is a two-arm, pilot randomized controlled trial in 40 adult patients newly diagnosed with breast cancer stages I-III who are scheduled to receive curative intent neo-adjuvant chemotherapy. Participants will be randomized 1:1 to a usual care waitlist control group or a home-based prehabilitation physical activity intervention delivered by a licensed physical therapist. The exercise group will receive an individualized, tapered exercise program comprised of home exercise sessions and virtual coaching calls. Both groups will receive activity monitors and be encouraged to maintain a healthy lifestyle during treatment. Participant adherence and adverse events will be assessed throughout the study.ResultsThis research was supported by the Alvin J. Siteman Cancer Center through The Foundation for Barnes-Jewish Hospital (award No. 6257). The protocol was approved by Washington University's Protocol Review and Monitoring Committee and Institutional Review Board. Enrollment began in May 2023 and is anticipated to continue through July 2024.ConclusionsThis study will provide the necessary preliminary data to support larger trials investigating if and how physical activity can be incorporated into early rehabilitation strategies to prevent chemotherapy-related sequelae.Trial registrationClinicalTrials.gov, NCT05716542.
Diagnostic potential of energy metabolism-related genes in heart failure with preserved ejection fraction
Authors: Gou Qiling , Zhao Qianqian , Dong Mengya , Liang Lei , You Hongjun 
Published: November 2023

BackgroundHeart failure with preserved ejection fraction (HFpEF) is associated with changes in cardiac metabolism that affect energy supply in the heart. However, there is limited research on energy metabolism-related genes (EMRGs) in HFpEF.MethodsThe HFpEF mouse dataset (GSE180065, containing heart tissues from 10 HFpEF and five control samples) was sourced from the Gene Expression Omnibus database. Gene expression profiles in HFpEF and control groups were compared to identify differentially expressed EMRGs (DE-EMRGs), and the diagnostic biomarkers with diagnostic value were screened using machine learning algorithms. Meanwhile, we constructed a biomarker-based nomogram model for its predictive power, and functionality of diagnostic biomarkers were conducted using single-gene gene set enrichment analysis, drug prediction, and regulatory network analysis. Additionally, consensus clustering analysis based on the expression of diagnostic biomarkers was utilized to identify differential HFpEF-related genes (HFpEF-RGs). Immune microenvironment analysis in HFpEF and subtypes were performed for analyzing correlations between immune cells and diagnostic biomarkers as well as HFpEF-RGs. Finally, qRT-PCR analysis on the HFpEF mouse model was used to validate the expression levels of diagnostic biomarkers.ResultsWe selected 5 biomarkers (Chrna2, Gnb3, Gng7, Ddit4l, and Prss55) that showed excellent diagnostic performance. The nomogram model we constructed demonstrated high predictive power. Single-gene gene set enrichment analysis revealed enrichment in aerobic respiration and energy derivation. Further, various miRNAs and TFs were predicted by Gng7, such as Gng7-mmu-miR-6921-5p, ETS1-Gng7. A lot of potential therapeutic targets were predicted as well. Consensus clustering identified two distinct subtypes of HFpEF. Functional enrichment analysis highlighted the involvement of DEGs-cluster in protein amino acid modification and so on. Additionally, we identified five HFpEF-RGs (Kcnt1, Acot1, Kcnc4, Scn3a, and Gpam). Immune analysis revealed correlations between Macrophage M2, T cell CD4+ Th1 and diagnostic biomarkers, as well as an association between Macrophage and HFpEF-RGs. We further validated the expression trends of the selected biomarkers through experimental validation.ConclusionOur study identified 5 diagnostic biomarkers and provided insights into the prediction and treatment of HFpEF through drug predictions and network analysis. These findings contribute to a better understanding of HFpEF and may guide future research and therapy development.
Germline ablation achieved via CRISPR/Cas9 targeting of NANOS3 in bovine zygotes
Authors: Mueller Maci L. , McNabb Bret R. , Owen Joseph R. , Hennig Sadie L. , Ledesma Alba V. , Angove Mitchell L. , Conley Alan J. , Ross Pablo J. , Van Eenennaam Alison L. 
Published: November 2023

NANOS3 is expressed in migrating primordial germ cells (PGCs) to protect them from apoptosis, and it is known to be a critical factor for germline development of both sexes in several organisms. However, to date, live NANOS3 knockout (KO) cattle have not been reported, and the specific role of NANOS3 in male cattle, or bulls, remains unexplored. This study generated NANOS3 KO cattle via cytoplasmic microinjection of the CRISPR/Cas9 system in vitro produced bovine zygotes and evaluated the effect of NANOS3 elimination on bovine germline development, from fetal development through reproductive age. The co-injection of two selected guide RNA (gRNA)/Cas9 ribonucleoprotein complexes (i.e., dual gRNA approach) at 6 h post fertilization achieved a high NANOS3 KO rate in developing embryos. Subsequent embryo transfers resulted in a 31% (n = 8/26) pregnancy rate. A 75% (n = 6/8) total KO rate (i.e., 100% of alleles present contained complete loss-of-function mutations) was achieved with the dual gRNA editing approach. In NANOS3 KO fetal testes, PGCs were found to be completely eliminated by 41-day of fetal age. Importantly, despite the absence of germ cells, seminiferous tubule development was not impaired in NANOS3 KO bovine testes during fetal, perinatal, and adult stages. Moreover, a live, NANOS3 KO, germline-ablated bull was produced and at sexual maturity he exhibited normal libido, an anatomically normal reproductive tract, and intact somatic gonadal development and structure. Additionally, a live, NANOS3 KO, germline-ablated heifer was produced. However, it was evident that the absence of germ cells in NANOS3 KO cattle compromised the normalcy of ovarian development to a greater extent than it did testes development. The meat composition of NANOS3 KO cattle was unremarkable. Overall, this study demonstrated that the absence of NANOS3 in cattle leads to the specific deficiency of both male and female germ cells, suggesting the potential of NANOS3 KO cattle to act as hosts for donor-derived exogenous germ cell production in both sexes. These findings contribute to the understanding of NANOS3 function in cattle and have valuable implications for the development of novel breeding technologies using germline complementation in NANOS3 KO germline-ablated hosts.
Induction chemoimmunotherapy may improve outcomes of chemoradiotherapy in patients with unresectable stage III NSCLC
Authors: Guan Song , Zhang Shufeng , Ren Kai , Li Xingyue , Li Xue , Zhao Lujun 
Published: November 2023

BackgroundCurrently, the value of induction chemoimmunotherapy before chemoradiotherapy (CRT) in unresectable stage III non-small cell lung cancer (NSCLC) has not been explored. This study was designed to explore the efficacy and safety of induction chemoimmunotherapy in patients with unresectable stage III NSCLC.MethodsUnresectable stage III NSCLC patients who received CRT with or without induction chemoimmunotherapy between August 2014 and December 2021 were retrospectively enrolled. Progression-free survival (PFS) and overall survival (OS) were assessed from the initiation of treatment and estimated by the Kaplan-Meier method. The potential factors affecting PFS and OS were analyzed by univariate and multivariate Cox regression models. One-to-one propensity score matching (PSM) was used to further minimize confounding.ResultsA total of 279 consecutive patients were enrolled, with 53 (19.0%) receiving induction chemoimmunotherapy followed by CRT (I-CRT group), and the remaining 226 (81.0%) receiving CRT alone (CRT group). After PSM, the median PFS was 24.8 months in the I-CRT group vs. 13.3 months in the CRT group (P=0.035). The median OS was not reached (NR) vs. 36.6 months ((P=0.142). The incidence of treatment-related adverse events (TRAEs) was similar in both groups, except that the incidence of hematological toxicity was higher in the I-CRT group (77.1% vs. 58.3%, P=0.049). Compared to induction chemotherapy, induction chemoimmunotherapy demonstrated a superior objective response rate (60.4% vs. 22.2%, P&lt;0.001) and further prolonged PFS (median NR vs. 13.2 months, P=0.009) and OS (median NR vs. 25.9 months, P=0.106) without increasing the incidence of TRAEs in patients receiving concurrent chemoradiotherapy.ConclusionInduction chemoimmunotherapy is safe and may improve outcomes of CRT in patients with unresectable stage III NSCLC. Moreover, induction chemoimmunotherapy may further improve treatment response and survival outcomes compared to induction chemotherapy before cCRT.