bluuebunny/crossref_metadata_2025_split huggingface dataset:
Assessment of the number of eye symptoms and the impact of some confounding variables for office staff in non‐air‐conditioned buildings
Authors: Doughty Michael J. , Blades Kenneth A. , Ibrahim Nassim 
Published: March 2003

Purpose:  The goal of this study was both to assess the frequency of self‐reported eye symptoms for employees in a non‐air‐conditioned office building complex, and to specifically assess whether confounding variables (contact lens wear, medicines use, and provoking stimuli) had a discernible impact on the characteristics of this reporting. Methods:  A questionnaire was distributed, in the winter months, to office employees in a building complex within a city‐located University site, consisting of non‐air‐conditioned rooms with some mechanical ventilation. The questionnaire asked respondents to identify any eye symptoms experienced (foreign body sensation, soreness, dryness, grittiness, itchiness, stinging, intense burning), the frequency of their occurrence, details of any conditions provoking eye symptoms (such as changes in the microenvironment), their medication use and if they were contact lens wearers. Results:  The proportion of respondents for various categories was calculated, along with the total number of symptoms. If `eye irritation' is considered as reporting any symptoms experienced at any time, then 63% of 292 respondents (median age 42.5 years) reported an average of 1.83 symptoms. However, the identification of contact lens wearers, medication use (especially for seasonal allergies) and provoking stimuli reduced this prevalence to just 29% (with the average number of symptoms being 1.51). If the frequency of experiencing symptoms was also taken into account (never, sometimes, often, and constantly), then only 12.3% of the respondents indicated symptoms often or constantly, i.e. could be considered to have significant symptoms. In all categories, men were more likely to report eye symptoms compared with women. Conclusions:  The results confirm that office employees are likely to have some ocular symptoms, but that even a simple consideration of possible confounding variables can greatly change the reported prevalence of eye irritation that might be specifically associated with the workplace environment.
The combined influence of knowledge, training and experience when grading contact lens complications
Authors: Efron Nathan , Morgan Philip B. , Jagpal Ritu 
Published: March 2003

AbstractPurpose: A study was conducted to evaluate the influence of knowledge, training and experience (clinical skills set) when assessing the severity of contact lens complications.Methods: Nine optometrists (who were in possession of a relevant clinical skills set) and nine ‘non‐optometrists’ (subjects without the clinical skills set) were each invited to grade – to the nearest 0.1 increment – an image of each of 16 contact lens complications using Efron Grading Scales for Contact Lens Complications. This procedure was repeated 2 weeks later, yielding a total data base comprising 576 individual grading estimates.Results: The mean of the test and retest grading estimates was the same for the optometrists (2.8 ± 0.7) and the non‐optometrists (2.6 ± 0.9) (F1,15,1 = 1.3, p = 0.26); that is, non‐optometrists can grade accurately. Median grading reliability for optometrists (±0.41) was lower than (i.e. superior to) that for non‐optometrists (±0.67) (p = 0.001). Non‐optometrists tended to display a reluctance to grade by interpolation and to less reliably grade subtle clinical signs.Conclusions: When averaged over several attempts, non‐optometrists will arrive at similar estimates of severity to optometrists when grading ocular complications of contact lens wear; however, they will do so less reliably. The relative contribution of the three attributes of the clinical skills set to grading performance is presently unclear.
Rate Your Plate: A Dietary Assessment and Educational Tool for Blood Cholesterol Control
Authors: Gans Kim M. , Hixson Mary Lynne , Eaton Charles B. , Lasater Thomas M. 
Published: March 2003

AbstractPractitioners who wish to deliver targeted nutritional advice to their patients for the prevention and management of elevated serum cholesterol levels must first assess their patients' diets. Unfortunately, many primary care providers do not have sufficient training in nutrition to do this adequately. In this situation, dietary assessment instruments would be useful; however, standard dietary assessment methods such as 24‐h recalls, food records, and food‐frequency questionnaires are inappropriate for use in this clinical setting. Rate Your Plate (RYP), a simplified food‐frequency questionnaire consisting of questions focusing on foods contributing the most fat, saturated fat, and cholesterol to the American diet, was developed by the Pawtucket Heart Health Program (PHHP) in the late 1980s and has been updated several times to reflect changes in national dietary recommendations. This review discusses the development and clinical applications of RYP and provides advice for its use in a primary care setting. A copy of a portion of the instrument is provided in the “Clinical Tools” section of this issue of Nutrition in Clinical Care.
Evaluation and Treatment of Iron Deficiency in Patients with Kidney Disease
Authors: Bickford Andrea K. 
Published: March 2003

AbstractIron deficiency is common in patients with kidney disease and is one of the primary causes for decreased response to recombinant human erthropoietin (rHuEPO) therapy. Serum ferritin and percent tranferrin saturation are regarded as the preferred indirect measurements of iron status. The National Kidney Foundation‐Kidney Disease Outcome Quality Initiative (K/DOQI) guidelines recommend levels openface>100 ng/ml and>20%, respectively. These tests, however, have practical limitations and lack sensitivity and specificity to identify “functional” iron deficiency, which can occur in the presence of normal or even increased iron stores. Newer methods of assessing iron status are becoming available, with reticulocyte hemoglobin content (CHr) showing the most promise at this time. K/DOQ1 guidelines recommend that adequacy of iron should be based on the amount of iron needed to sufficiently achieve target hemoglobin and hematocrit levels of 11–12 g/dL, or 33–36%. Studies have demonstrated for a majority of hemodialysis and some predialysis and peritoneal dialysis patients that intravenous iron therapy is necessary to improve response, thus reducing the amount of rHuEPO needed to achieve these goals. Though intravenous iron is generally regarded as safe and effective, caution should be taken in regard to acceptable amounts of supplementation and long‐term effects with the potential risk of iron overload.
The ultra‐high pressure coronitic and pseudomorphous reactions in a metagranodiorite from the Brossasco‐Isasca Unit, Dora‐Maira Massif, western Italian Alps: a petrographic study and equilibrium thermodynamic modelling
Authors: Bruno M. , Compagnoni R. , Rubbo M. 
Published: March 2003

AbstractMetagranodiorite samples from the Brossasco‐Isasca Unit, Dora‐Maira Massif, western Alps, show pseudomorphous and coronitic textures where igneous minerals were partially replaced by ultra‐high pressure (UHP) metamorphic assemblages. The original magmatic paragenesis consisted of quartz, plagioclase, K‐feldspar, biotite and minor phases. During UHP metamorphism, the plagioclase (site P) was replaced by zoisite, jadeite, quartz, K‐feldspar and kyanite, and coronitic reactions developed between biotite and adjacent minerals. At the original igneous biotite–quartz contact (site A), a single corona of poorly zoned garnet is developed, whereas at the biotite–K‐feldspar (site B) and biotite–plagioclase (site C) contacts, composite coronas are formed. Integration of results from petrographic observations, calculations of mineral stoichiometry and thermodynamic calculations of mineral stability has allowed the determination of the metamorphic reactions involved and the estimation of the metamorphic conditions, which reached as high as 24 kbar and 650 °C. Accurate microanalysis by energy‐dispersive spectroscopy (EDS) and statistical analysis of the data allowed us to identify, for the first time in a natural Na‐pyroxene of metagranitoid rocks, the end‐member Ca‐Eskola.
Formation and exhumation of blueschists and eclogites from NE Oman: new perspectives from Rb–Sr and 40Ar/39Ar dating
Authors: El‐Shazly A. K. , Bröcker M. , Hacker B. , Calvert A. 
Published: March 2003

AbstractSeven eclogite facies samples from lithologically different units which structurally underlie the Semail ophiolite were dated by the 40Ar/39Ar and Rb–Sr methods. Despite extensive efforts, phengite dated by the 40Ar/39Ar method yielded saddle, hump or irregularly shaped spectra with uninterpretable isochrons. The total gas ages for the phengite ranged from 136 to 85 Ma. Clinopyroxene–phengite, epidote–phengite and whole‐rock–phengite Rb–Sr isochrons for the same samples yielded ages of 78 ± 2 Ma. We therefore conclude that the eclogite facies rocks cooled through 500 °C at c. 78 ± 2 Ma, and that the 40Ar/39Ar dates can only constrain maximum ages due to the occurrence of excess Ar inhomogeneously distributed in different sites.Our new results lead us to conclude that high‐pressure metamorphism of the Oman margin took place in the Late Cretaceous, contemporaneous with ophiolite emplacement. Previously published structural and petrological data lead us to suggest that this metamorphism resulted from intracontinental subduction and crustal thickening along a NE‐dipping zone. Choking of this subduction zone followed by ductile thinning of a crustal mass wedged between deeply subducted continental material and overthrust shelf and slope units facilitated the exhumation of the eclogite facies rocks from depths of c. 50 km to 10–15 km within c. 10 Ma, and led to their juxtaposition against overlying lower grade rocks. Final exhumation of all high‐pressure rocks was driven primarily by erosion and assisted by normal faulting in the upper plate.
Diffusion‐controlled growth of wollastonite rims between quartz and calcite: comparison between nature and experiment
Authors: Milke R. , Heinrich W. 
Published: March 2003

AbstractGrowth rates of wollastonite reaction rims between quartz and calcite were experimentally determined at 0.1 and 1 GPa and temperatures from 850 to 1200 °C. Rim growth follows a parabolic rate law indicating that this reaction is diffusion‐controlled. From the rate constants, the D′δ‐values of the rate‐limiting species were derived, i.e. the product of grain boundary diffusion coefficient D′ and the effective grain boundary width, δ. In dry runs at 0.1 GPa, wollastonite grew exclusively on quartz surfaces. From volume considerations it is inferred that (D′CaOδ)/(D′SiO2δ)≥1.33, and that SiO2 diffusion controls rim growth. D′SiO2δ increases from about 10−25 to 10−23 m3 s−1 as temperature increases from 850 to 1000 °C, yielding an apparent activation energy of 330±36 kJ mol−1. In runs at 1 GPa, performed in a piston‐cylinder apparatus, there were always small amounts of water present. Here, wollastonite rims always overgrew calcite. Rims around calcite grains in quartz matrix are porous and their growth rates are controlled by a complex diffusion‐advection mechanism. Rim growth on matrix calcite around quartz grains is controlled by grain boundary diffusion, but it is not clear whether CaO or SiO2 diffusion is rate‐limiting. D′δ increases from about 10−21 to 10−20 m3 s−1 as temperature increases from 1100 to 1200 °C. D′SiO2δ or D′CaOδ in rims on calcite is c. 10 times larger than D′SiO2δ in dry rims at the same temperature. Growth structures of the experimentally produced rims are very similar to contact‐metamorphic wollastonite rims between metachert bands and limestone in the Bufa del Diente aureole, Mexico, whereby noninfiltrated metacherts correspond to dry and brine‐infiltrated metacherts to water‐bearing experiments. However, the observed diffusivities were 4 to 5 orders of magnitude larger during contact‐metamorphism as compared to our experimental results.
High‐pressure granulites in the Sanggan area, North China craton: metamorphic evolution, P–T paths and geotectonic significance
Authors: Guo J. H. , O'Brien P. J. , Zhai M. 
Published: March 2003

AbstractHigh‐pressure basic granulites are widely distributed as enclaves and sheet‐like blocks in the Huaian TTG gneiss terrane in the Sanggan area of the Central Zone of the North China craton. Four stages of the metamorphic history have been recognised in mineral assemblages based on inclusion, exsolution and reaction textures integrated with garnet zonation patterns as revealed by compositional maps and compositional profiles. The P–T conditions for each metamorphic stage were obtained using thermodynamically and experimentally calibrated geothermobarometers. The low‐Ca core of growth‐zoned garnet, along with inclusion minerals, defines a prograde assemblage (M1) of garnet + clinopyroxene + plagioclase + quartz, yielding 700 °C and 10 kbar. The peak of metamorphism at about 750–870 °C and 11–14.5 kbar (M2) is defined by high‐Ca domains in garnet interiors and inclusion minerals of clinopyroxene, plagioclase and quartz. Kelyphites or coronas of orthopyroxene + plagioclase ± magnetite around garnet porphyroblasts indicate garnet breakdown reactions (M3) at conditions around 770–830 °C and 8.5–10.5 kbar. Garnet exsolution lamellae in clinopyroxene and kelyphites of amphibole + plagioclase around garnet formed during the cooling process at about 500–650 °C and 5.5–8 kbar (M4). These results help define a sequential P–T path containing prograde, near‐isothermal decompression (ITD) and near‐isobaric cooling (IBC) stages.The clockwise hybrid ITD and IBC P–T paths of the HP granulites in the Sanggan area imply a model of thickening followed by extension in a collisional environment. Furthermore, the relatively high‐pressures (6–14.5 kbar) of the four metamorphic stages and the geometry of the P–T paths suggest that the HP granulites, together with their host Huaian TTG gneisses, represent the lower plate in a crust thickened during collision. The corresponding upper‐plate might be the tectonically overlying Khondalite series, which was subjected to medium‐ to low‐pressure (MP/LP: 7–4 kbar) granulite facies metamorphism with a clockwise P–T path including an ITD segment. Both the HP and the MP/LP granulite facies events occurred contemporaneously at c. 1.90–1.85 Ga in a collisional environment created by the assembly process of the North China craton.
Blueschist metamorphism during accretion in the Lachlan Orogen, south‐eastern Australia
Authors: Spaggiari C. V. , Gray D. R. , Foster D. A. 
Published: March 2003

AbstractLow‐T, intermediate to high‐P assemblages indicative of the prehnite–pumpellyite, greenschist and blueschist facies are preserved in mélange zones and slivers of oceanic crust within two major fault zones of the turbidite‐dominated Lachlan Orogen. In one of these fault zones (Governor Fault Zone), blueschists occur as Franciscan‐like blocks in a serpentinite/talc matrix that is interleaved with phyllites and slates, and structurally overlain by a fault slice or duplex of predominantly pillow basalt, chert, and turbidite. The blueschist metavolcanics are interpreted to have formed at < 450 °C and at a depth of approximately 21–27 km. The presence of blue amphibole in the blocks, rinds and matrix indicate that the metavolcanics were emplaced in the matrix prior to blueschist metamorphism. Blocks and matrix were partially exhumed, interleaved with tectonic slices of phyllite and slate, and subsequently folded at about 10–12 km depth, inferred from bo values of the dominant mica fabric in the phyllites and slates. Metamorphic P–T is highest in the structurally lowest slice (mélange zone) and lowest in the overlying ophiolitic fault slice, suggestive of an accretionary burial metamorphic pattern formed by underplating of the mélange. In the other fault zone (Heathcote Fault Zone), blueschists transitional to greenschist facies are interpreted to have formed at < 450 °C and at a depth of approximately 15–21 km. They occur as blocks in serpentinite/talc‐matrix mélange and are also associated with fault slices of oceanic crust. Textural and mineralogical evidence suggests that the protoliths for the blueschists in both fault zones were boninitic pillow lavas. The metamorphic facies and patterns, and the structural and lithological associations, can be interpreted in terms of disruption of oceanic crust and overlying sediments during subduction, and formation of serpentinite‐matrix mélange overprinted by blueschist metamorphism either prior to or during underplating of the mélange and duplex formation. The presence of blueschist metavolcanics indicate that these processes occurred at considerable depth. These interpretations have implications for the evolution of large‐scale fault zones in noncollisional, convergent oceanic settings.
Kyanite‐paragonite‐bearing assemblages, northern Fiordland, New Zealand: rapid cooling of the lower crustal root to a Cretaceous magmatic arc
Authors: Daczko N. R. , Clarke G. L. , Klepeis K. A. 
Published: March 2003

AbstractFiordland, New Zealand exposes the lower crustal root of an Early Cretaceous magmatic arc that now forms one of Earth's most extensive high‐P granulite facies belts. The Arthur River Complex, a dioritic to gabbroic suite in northern Fiordland, is part of the root of the arc, and records an Early Cretaceous history of emplacement, tectonic burial, and high‐P granulite facies metamorphism that accompanied partial melting of the crust. Late random intergrowths of kyanite, quartz and plagioclase partially pseudomorph minerals in the earlier high‐T assemblages of the Arthur River Complex, indicating high‐P cooling of an over thickened crustal root by c. 200 °C. The kyanite intergrowths are themselves partially pseudomorphed by paragonite, commonly in the presence of phengitic white mica. Biotite–plagioclase intergrowths that partially pseudomorph phengitic white mica and diopside–plagioclase intergrowths that partially pseudomorph jadeitic diopside, combined with published thermochronology results, are consistent with later rapid decompression. A short duration anticlockwise P–T path may be explained by the high‐P juxtaposition of comparatively cool upper crustal rocks following their tectonic burial and under thrusting during the waning stages of Early Cretaceous orogenesis. This was then followed by the decompression giving the rapid exhumation within 20 Myr of peak metamorphism, as suggested by the isotopic data.
The Comparative Safety of Intravenous Iron Dextran, Iron Saccharate, and Sodium Ferric Gluconate
Authors: Fishbane Steven , Kowalski Edward A. 
Published: March 2003

ABSTRACTIntravenous iron treatment is an important component of anemia therapy for patients on dialysis. Until recently iron dextran was the only parenteral form of iron available in the United States. This drug has been associated with occasional serious adverse reactions, including full‐blown anaphylaxis. In 1999 the Food and Drug Administration approved a second form of iron for intravenous administration, sodium ferric gluconate in sucrose. It is expected that by the time of this publication, a third agent, iron saccharate will also be approved. In this review the comparative safety of these three agents is critically evaluated.
Compartment Effects in Hemodialysis
Authors: Schneditz Daniel , Daugirdas John T. 
Published: March 2003

ABSTRACTCompartment effects in hemodialysis are important because they reduce the efficiency of removal of the compartmentalized solute during dialysis. The dialyzer can only remove those waste products that are presented to it, and then only in proportion to the concentration of the solute in the blood. Classically a two‐compartment system has been modeled, with the compartments arranged in series. Because modeling suggests that the sequestered compartment is larger than the accessible compartment, an assumption has been made that the sequestered compartment is the intracellular space. For urea and other solutes that move easily across many cell membranes, compartmentalization may be flow related, that is, related to sequestration in organs (muscle, skin, bone). Although mathematically urea rebound and mass balance can be described with either model, the flow‐related model best explains data showing that urea rebound after dialysis is increased during ultrafiltration, diminished during high cardiac output states, and also reduced during exercise. Whether compartmentalization is increased in vasoconstricted intensive care unit patients receiving acute dialysis remains an open question.
Treating Interdialytic Hyperkalemia with Fludrocortisone
Authors: Imbriano Louis J. , Durham John H. , Maesaka John K. 
Published: March 2003

AbstractHyperkalemia is a frequent and dangerous problem in dialysis patients. Many factors contribute to potentially life‐threatening potassium elevation and most remedies used to treat hyperkalemia are handicapped by the consequences of the separate pools of intra‐ and extracellular potassium. Besides the kidney, the colon has the ability to excrete potassium, which can help lower total body potassium. Several prior authors have addressed the colon's ability to up‐regulate potassium secretion, including the effect of aldosterone on fecal potassium content. Potentially dangerous intradialytic maneuvers to lower potassium levels may be avoidable with the use of the mineralocorticoid agonist fludrocortisone.
Race and Prostate Cancer: What Do We Know?
Authors: Young C. Dale , Roach Mack 
Published: March 2003

AbstractObjectives: Is race an independent prognostic indicator of outcome and overall survival in prostate cancer? African American men have been reported to have the highest incidence and mortality rates for prostate cancer worldwide, but the evidence to explain this is confusing at best.Materials and Methods: A literature search was conducted, and an effort was made to include all articles published in the last 15 years that evaluated the independent significance of race on survival or disease‐free survival from prostate cancer. Special attention was given to the major prospective randomized trials in which the initial workups, evaluations, and treatments were relatively uniform and in which the opportunity for confounding variables were small.Results: The appearance of a difference in outcome due to race is most likely a result of an epidemiologic phenomenon that arises when evaluating two different populations that have different distributions with regard to severity of disease. African Americans tend to present with higher prostate specific antigen (PSA) levels and higher Gleason scores, and a larger percentage are likely to belong to the groups with the higher risk of failure, creating the impression that failure is due to race.Conclusions: On examination of the prospective randomized trials in the literature, “race‐based” explanations for differences in survival should be viewed with a moderate degree of skepticism. So‐called “epigenetic” factors may explain the higher incidence of prostate cancer noted in numerous studies.