bluuebunny/crossref_metadata_2025_split huggingface dataset:
Kant y la conciencia moral
Authors: Vigo Pacheco Alejandro Gustavo 
Published: November 2023

Este libro del profesor Alejandro G. Vigo ofrece un comentario lúcido y riguroso a los textos en los que Kant aborda el tema de la conciencia moral (Gewissen). Ello comprende las Lecciones de filosofía moral, La Religión en los límites de la mera razón y la "Doctrina de la virtud" que es la segunda parte de la Metafísica de las costumbres. Vigo explica tanto el papel sistemático de la conciencia moral en la filosofía kantiana como la evolución del tópico en la comprensión del filósofo de Königsberg. La conciencia moral es tratada por Kant como una importantísima prestación de la facultad de juzgar en su función reflexiva. El tema es fundamental en la filosofía moral kantiana y en el pensamiento de autores posteriores, que no podría ser comprendido sin la referencia a Kant. Pero además se abordan aquí discusiones que son centrales en toda la tradición filosófica de Occidente. El volumen ofrece así un gran aporte al pensamiento filosófico y en particular a la reflexión ética: muestra la centralidad del tema de la conciencia moral en la filosofía de Kant con la reconstrucción clara y precisa de una teoría que quedaría de otro modo dispersa, en tanto no es presentada por el propio Kant de modo unitario en algún pasaje.
L’ingénierie et ses mythes
Authors: Gaudin Olivier , Lerbet-Sereni Frédérique 
Published: November 2023

Si la professionnalisation des métiers du social se fait de plus en plus
souvent selon le modèle d’une ingénierie de professionnalisation, quels imaginaires
sous-tendent ce mouvement ? Comment comprendre que le métier d’ingénieur, celui qui, au
moins dans l’imaginaire, invente et conçoit des machines au fonctionnement magiquement
prévisible, puisse être le modèle permettant de concevoir des dispositifs de formation aux
métiers de la relation ? Cette contribution propose d’explorer ces questions à travers deux
figures mythologiques souvent convoquées lorsqu’il est question d’ingénierie et de
technique : Prométhée, et Héphaïstos. Ces deux figures nous aideront à passer du modèle
d’une ingénierie de la professionnalisation à l’ingenium.
Former à, par ou pour la recherche, en ingénierie de formation : le cas d’un Master en formation d’adultes
Authors: Eneau Jérôme , Brémaud Loïc 
Published: November 2023

Mises en place graduellement depuis 2002 et dans l’héritage du « Processus de Bologne » amorcé à la fin des années 1990, les réformes successives de l’enseignement universitaire, en France, ont profondément modifié le paysage des diplômes professionnels supérieurs. Les Diplômes d’Enseignement Supérieur Spécialisé (DESS), devenus des Masters professionnels, offrent un exemple paradigmatique des tensions entre les finalités anciennes de professionnalisation, à l’université, et celle d’un enseignement à, par ou pour la recherche, présent dans ces diplômes. Le cas du Master professionnel « Stratégie et Ingénierie en Formation d’Adultes » (SIFA), à l’université Rennes-2, permet d’illustrer cette problématique.
Change in demand for health-related undergraduate studies in Spain during 2015–2021: a temporal series study
Authors: Jerez-Roig Javier , Bezerra de Souza Dyego L. , Cambra-Badii Irene , March-Amengual Jaume-Miquel , Comella Agustí , Masó-Aguado Montse , Ramon-Aribau Anna , Luque-Suárez Alejandro , Feito Grande Lydia , Terribas Núria , Vivanco Luis , Busquets-Alibés Ester 
Published: November 2023

Introduction
The expansion of higher education is a worldwide phenomenon. To our knowledge, there are no studies analyzing the trends in demands of enrollment in health-related studies in Spain. Therefore, the objective was to analyze the change in demand (the number of requests for enrollment divided by the number of offered places) for undergraduate health-related studies in Spain during the period 2015–2021 as well as compare the change by region in the pre (2015–2019) and pandemic (2020–2021) period.

Methods
This is an observational (ecological type) study with temporal series analyses using data from public (non-for-profit) higher education institutions from the Integrated University Information System. For the analysis by region, we calculated the demand of all twelve undergraduate health-related degrees and the percentages of change between both periods using the Wilcoxon test. The Joinpoint Regression program was used to analyze the trends in demand for each degree during the 7-year period.

Results
Significant (p < 0.001) increases in demand during the pandemic period were observed in all regions. During the pandemic, medicine, biomedicine, nursing, odontology and pharmacy presented a higher demand in comparison with data collected before the pandemic started. In contrast, this pattern was not confirmed in the following cases: physiotherapy, occupational therapy, podiatry, psychology, social work, human nutrition and dietetics. By regions, Navarra, Asturias, and La Rioja presented the most drastic changes. In regions with the biggest number of universities, such as Catalonia, Andalusia and Madrid, the change observed was smaller.
Fluoroquinolone resistance determinants in carbapenem-resistant Escherichia coli isolated from urine clinical samples in Thailand
Authors: Boueroy Parichart , Chopjitt Peechanika , Hatrongjit Rujirat , Morita Masatomo , Sugawara Yo , Akeda Yukihiro , Iida Tetsuya , Hamada Shigeyuki , Kerdsin Anusak 
Published: November 2023

Background
Escherichia coli is the most common cause of urinary tract infections and has fluoroquinolone (FQ)-resistant strains, which are a worldwide concern.

Objectives
To characterize FQ-resistant determinants among 103 carbapenem-resistant E. coli (CREc) urinary isolates using WGS.

Methods
Antimicrobial susceptibility, biofilm formation, and short-read sequencing were applied to these isolates. Complete genome sequencing of five CREcs was conducted using short- and long-read platforms.

Results
ST410 (50.49%) was the predominant ST, followed by ST405 (12.62%) and ST361 (11.65%). Clermont phylogroup C (54.37%) was the most frequent. The genes NDM-5 (74.76%) and CTX-M-15 (71.84%) were the most identified. Most CREcs were resistant to ciprofloxacin (97.09%) and levofloxacin (94.17%), whereas their resistance rate to nitrofurantoin was 33.98%. Frequently, the gene aac(6′)-Ib (57.28%) was found and the coexistence of aac(6′)-Ib and blaCTX-M-15 was the most widely predominant. All isolates carried the gyrA mutants of S83L and D87N. In 12.62% of the isolates, the coexistence was detected of gyrA, gyrB, parC, and parE mutations. Furthermore, the five urinary CREc-complete genomes revealed that blaNDM-5 or blaNDM-3 were located on two plasmid Inc types, comprising IncFI (60%, 3/5) and IncFI/IncQ (40%, 2/5). In addition, both plasmid types carried other resistance genes, such as blaOXA-1, blaCTX-M-15, blaTEM-1B, and aac(6′)-Ib. Notably, the IncFI plasmid in one isolate carried three copies of the blaNDM-5 gene.

Conclusions
This study showed FQ-resistant determinants in urinary CREc isolates that could be a warning sign to adopt efficient strategies or new control policies to prevent further spread and to help in monitoring this microorganism.
Performance of Plant Spacing Using Cut Seed Tubers of Different Varieties on Growth Parameters, Yield Attributes and Yield
Authors: Dagar Sandeep , Panghal V. P. S. , Vats Chaman , Asha  , Fandan Renu , Kumar Sunil , Akash  
Published: November 2023

Aim: Potato is one of the most prominent crops to eliminate hunger and poverty at the global level. It is one of the world's most widely consumed and important food crops, providing a significant portion of the world's dietary energy and nutrients.
Methodology: The study was carried out at the research farm of Vegetable Science, Chaudhary Charan Singh Haryana Agricultural University- Hisar, India during the rabi season of the year 2021-22. The field experiment was conducted in a split-plot design with three potato varieties (Kufri Neelkanth, Kufri Bahar and Kufri Lima) and four different spacing (60×10 cm, 60×15 cm, 60×20 cm with cut tuber and 60×20 cm with whole tuber).
Results: Among different spacings and varieties, spacing 60×20 cm with whole tuber and Kufri Neelkanth was found best for plant height at 60, 75 and 90 days after planting, number of leaves/hill, leaves weight/hill (g), stem weight/hill (g), weight of fresh foliage (kg/m2) and and total tuber yield (q/ha), biological yield (q/ha), respectively. Whereas, Kufri Bahar was found maximum for the number of stems/hill (7.22) and Kufri Lima for total marketable tuber yield (374.4 q/ha).
Conclusion: The present study opens up new doors to the farmers and researchers for sustainable production of potatoes. The findings can be useful for farmers and researchers in developing effective strategies for improving the production of potato, which can have significant economic and nutritional benefits.
Depletion Type Organic Electrochemical Transistors and the Gradual Channel Approximation
Authors: Skowrons Michael , Dahal Drona , Paudel Pushpa Raj , Lüssem Björn 
Published: November 2023

AbstractThe gradual channel approximation forms the foundation for the analysis of field‐effect transistors. It has been used to discuss transistors that are not necessarily based on the field‐effect as well, such as the organic electrochemical transistor (OECT). Here, the applicability of the gradual channel approximation for OECTs is studied by a 2D drift‐diffusion model. It is found that OECT switching can be described by two separate effects—a doping/dedoping mechanism and the formation of an electrostatic double layer at the interface between the mixed conductor and the electrolyte. The balance between these two mechanisms is determined by the morphology of the mixed conductor, in particular the question if ions move in the same phase and electric potential as the holes, or if separate ion and hole phases are formed. It is argued that the gradual channel approximation can only be used to describe electrostatic switching at the mixed conductor/electrolyte interface (the two‐phase model), but cannot be employed to analyze devices operating on a doping/de‐doping mechanism (the one‐phase model).
Post‐Synthetic Modification of Aerogels Made of Covalent Cross‐linked Metal‐Organic Polyhedra
Authors: Khobotov‐Bakishev Akim , Samanta Partha , Roztocki Kornel , Albalad Jorge , Royuela Sergio , Furukawa Shuhei , Zamora Félix , Carné‐Sánchez Arnau , Maspoch Daniel 
Published: November 2023

AbstractAerogels are porous ultralight materials known for their high porosity, wide range of pore sizes, low density, and good macroscopic mechanical properties, all of which make them promising candidates for shaped adsorbents, catalysts, and insulators, among other applications. Here, this work reports a new approach that enables both the formation of modular aerogels, via dynamic covalent chemistry, and their post‐synthetic modification, via coordination chemistry. To demonstrate this strategy, this work first polymerizes porous amino‐functionalized Rh(II)‐based metal‐organic polyhedra (MOPs) with aldehydes, which afforded robust imine‐gel networks that is then converted into aerogels. Next, this work functionalizes these aerogels through the coordination of ligands on the axial site of Rh(II) paddlewheels of the MOP. Interestingly, in this chemistry, the local changes in the coordination site of the MOPs are transferred to the overall aerogel, thereby altering its macroscopic physicochemical properties. Importantly, this feature enables the synthesis of optimized adsorbents tailored to specific guests, as this work demonstrates through a series of experiments using ligands of different electrostatic and hydrophobic characters.
Functional Hydrogel Co‐Remolding Migration and Differentiation Microenvironment for Severe Spinal Cord Injury Repair
Authors: Liu Dingyang , Shen He , Zhang Kai , Shen Yeyu , Wen Runlin , He Xinghui , Long Ge , Li Xing 
Published: November 2023

AbstractSpinal cord injury (SCI) activates nestin+ neural stem cells (NSCs), which can be regarded as potential seed cells for neuronal regeneration. However, the lesion microenvironment seriously hinders the migration of the nestin+ cells to the lesion epicenter and their differentiation into neurons to rebuild neural circuits. In this study, a photosensitive hydrogel scaffold is prepared as drug delivery carrier. Genetically engineered SDF1α and NT3 are designed and the scaffold is binary modified to reshape the lesion microenvironment. The binary modified scaffold can effectively induce the migration and neuronal differentiation of nestin+ NSCs in vitro. When implanted into a rat complete SCI model, many of the SCI‐activated nestin+ cells migrate into the lesion site and give rise to neurons in short‐term. Meanwhile, long‐term repair results also show that implantation of the binary modified scaffold can effectively promote the maturation, functionalization and synaptic network reconstruction of neurons in the lesion site. In addition, animals treated with binary scaffold also showed better improvement in motor functions. The therapeutic strategy based on remolding the migration and neuronal differentiation lesion microenvironment provides a new insight into SCI repair by targeting activated nestin+ cells, which exhibits excellent clinical transformation prospects.
Reducing Perovskite/C60 Interface Losses via Sequential Interface Engineering for Efficient Perovskite/Silicon Tandem Solar Cell
Authors: Liu Zhou , Li Hongjiang , Chu Zijing , Xia Rui , Wen Jin , Mo Yi , Zhu Hesheng , Luo Haowen , Zheng Xuntian , Huang Zilong , Luo Xin , Wang Bo , Zhang Xueling , Yang Guangtao , Feng Zhiqiang , Chen Yifeng , Kong Wenchi , Gao Jifan , Tan Hairen 
Published: November 2023

AbstractWide‐bandgap (WBG) perovskite solar cells hold tremendous potential for realizing efficient tandem solar cells. However, nonradiative recombination and carrier transport losses occurring at the perovskite/electron‐selective contact (e.g. C60) interface present significant obstacles in approaching their theoretical efficiency limit. To address this, a sequential interface engineering (SIE) strategy that involves the deposition of ethylenediamine diiodide (EDAI2) followed by sequential deposition of 4‐Fluoro‐Phenethylammonium chloride (4F‐PEACl) is implemented. The SIE technique synergistically narrows the conduction band offset and reduces recombination velocity at the perovskite/C60 interface. The best‐performing WBG perovskite solar cell (1.67 eV) delivers a power conversion efficiency (PCE) of 21.8% and an impressive open‐circuit voltage of 1.262 V. Moreover, through integration with double‐textured silicon featuring submicrometer pyramid structures, a stabilized PCE of 29.6% is attained for a 1 cm2 monolithic perovskite/silicon tandem cell (certified PCE of 29.0%).
Diffusible Capping Layer Enabled Homogeneous Crystallization and Component Distribution of Hybrid Sequential Deposited Perovskite
Authors: Xu Qiaojing , Shi Biao , Li Yucheng , Liu Jingjing , Li Yuxiang , SunLi Zetong , Liu Pengfei , Zhang Yubo , Sun Cong , Han Wei , Huang Qian , Zhang Dekun , Ren Huizhi , Du Xiaona , Zhao Ying , Zhang Xiaodan 
Published: November 2023

AbstractNowadays, the development of wide‐bandgap perovskite by thermal evaporation and spin‐coating hybrid sequential deposition (HSD) method has special meaning on textured perovskite/silicon tandem solar cells. However, the common issues of insufficient reaction caused by blocking of perovskite capping layer are exacerbated in HSD, because evaporated precursors are usually denser with higher crystallinity and the widely used additive‐assisted microstructure is also difficult to access. Here, a facile “diffusible perovskite capping layer” (DPCL) strategy to solve this dilemma is presented. With DPCL, crystallization alleviation of perovskite and more diffusion channels of organic salts can be realized simultaneously, contributing to a homogenization process. The resultant perovskite films exhibit complete conversion, uniform crystallization, enhanced quality, and reduced defect, leading to obvious improvements in device efficiency, repeatability, and stability. This work offers a way to promote the development of textured tandems a step further.
High Output Power and High Quantum Efficiency in Novel NIR Phosphor MgAlGa0.7B0.3O4:Cr3+ with Profound FWHM Variation
Authors: Zhong Chuansheng , Xu Yonghui , Wu Xiudi , Yin Shuwen , Zhang Xibao , Zhou Liang , You Hongpeng 
Published: November 2023

AbstractThere is strong demand for ultraefficient near‐infrared (NIR) phosphors with adjustable emission properties for next‐generation intelligent NIR light sources. Designing phosphors with large full‐width at half‐maximum (FWHM) variations is challenging. In this study, novel near‐ultraviolet light‐emitting diode (LED)‐excited NIR phosphors, MgAlGa0.7B0.3O4:Cr3+ (MAGBO:Cr3+), with three emission centers achieve ultra‐narrowband (FWHM = 29 nm) to ultra‐broadband (FWHM = 260 nm) emission with increasing Cr3+ concentration. Gaussian fitting and decay time analysis reveal the alteration in the FWHM, which is attributed to the energy transfer occurring between the three emission centers. The distinct thermal quenching behaviors of the three emission centers are revealed through the temperature‐dependent decay times. The ultra‐broadband NIR phosphor MAGBO:0.05Cr3+ exhibits high thermal stability (85%, 425 K) and exceptional external quantum efficiency of 68.5%. An NIR phosphor‐converted LED (pc‐LED) is fabricated using MAGBO:0.05Cr3+ phosphor, exhibiting a remarkable NIR output power of 136 mW at 600 mA in ultra‐broadband NIR pc‐LEDs. This study describes the preparation of highly efficient phosphors and provides a further understanding of the tunable FWHM, which is vital for high‐performance NIR phosphors with versatile applications.
Ultrathin Clay Nanoparticles‐Mediated Mutual Reinforcement of Ferroptosis and Cancer Immunotherapy
Authors: Liu Jianping , Zhan Jiezhao , Zhang Ye , Huang Lin , Yang Jing , Feng Jie , Ding Lingwen , Shen Zheyu , Chen Xiaoyuan 
Published: November 2023

AbstractFerroptosis‐triggered immunogenic cell death (ICD) is widely adopted to potentiate the body's antitumor immunity by catalyzing the production of toxic reactive oxygen species (ROS). However, the efficacy of ferroptosis and immunotherapy is greatly restricted by intracellular abundant glutathione (GSH) and immunosuppressive tumor microenvironment (TME). Herein, a facile bottom‐up method for solvent‐free synthesis of ultrathin manganese (Mn)‐based layered double hydroxide nanosheets with high loading efficiency for pro‐inflammatory cytokine interferon (IFNγ) (IFNγ/uMn‐LDHs) is proposed to mutually reinforce the ferroptosis and systemic immunity. The introduction of manganese ions significantly contributes to GSH depletion and hydroxyl radical generation, which can be further enhanced by IFNγ delivery‐induced SLC7A11 downregulation. The ICD effect after cell ferroptosis cooperates with the intrinsic immunomodulatory property of IFNγ/uMn‐LDHs to facilitate the maturation of dendritic cells (DCs) and the priming of T cells. IFNγ secretion from activated CD8+ T cells in turn involves cascade immunogenic ferroptosis, thus constructing a closed‐loop therapy. Remarkably, a potent abscopal effect is observed in the growth inhibition of both primary and distant tumors. Overall, the ultrathin Mn‐based clay nanoplatform provides a simple approach for mutual regulation between ferroptosis and antitumor immune response, overcoming the obstacles of current cancer immunotherapy.
Multi‐Functional Small Molecule Alleviates Fracture Pain and Promotes Bone Healing
Authors: Shih Yu‐Ru V. , Kingsley David , Newman Hunter , Hoque Jiaul , Gupta Ankita , Lascelles B. Duncan X. , Varghese Shyni 
Published: November 2023

AbstractBone injuries such as fractures are one major cause of morbidities worldwide. A considerable number of fractures suffer from delayed healing, and the unresolved acute pain may transition to chronic and maladaptive pain. Current management of pain involves treatment with NSAIDs and opioids with substantial adverse effects. Herein, we tested the hypothesis that the purine molecule, adenosine, can simultaneously alleviate pain and promote healing in a mouse model of tibial fracture by targeting distinctive adenosine receptor subtypes in different cell populations. To achieve this, a biomaterial‐assisted delivery of adenosine is utilized to localize and prolong its therapeutic effect at the injury site. The results demonstrate that local delivery of adenosine inhibited the nociceptive activity of peripheral neurons through activation of adenosine A1 receptor (ADORA1) and mitigated pain as demonstrated by weight bearing and open field movement tests. Concurrently, local delivery of adenosine at the fracture site promoted osteogenic differentiation of mesenchymal stromal cells through adenosine A2B receptor (ADORA2B) resulting in improved bone healing as shown by histological analyses and microCT imaging. This study demonstrates the dual role of adenosine and its material‐assisted local delivery as a feasible therapeutic approach to treat bone trauma and associated pain.
3D Printed Conformal Strain and Humidity Sensors for Human Motion Prediction and Health Monitoring via Machine Learning
Authors: Hou Yanbei , Gao Ming , Gao Jingwen , Zhao Lihua , Teo Edwin Hang Tong , Wang Dong , Qi H. Jerry , Zhou Kun 
Published: November 2023

AbstractWearable sensors have garnered considerable attention due to their flexibility and lightweight characteristics in the realm of healthcare applications. However, developing robust wearable sensors with facile fabrication and good conformity remains a challenge. In this study, a conductive graphene nanoplate‐carbon nanotube (GC) ink is synthesized for multi jet fusion (MJF) printing. The layer‐by‐layer fabrication process of MJF not only improves the mechanical and flame‐retardant properties of the printed GC sensor but also bolsters its robustness and sensitivity. The direction of sensor bending significantly impacts the relative resistance changes, allowing for precise investigations of joint motions in the human body, such as those of the fingers, wrists, elbows, necks, and knees. Furthermore, the data of resistance changes collected by the GC sensor are utilized to train a support vector machine with a 95.83% accuracy rate for predicting human motions. Due to its stable humidity sensitivity, the sensor also demonstrates excellent performance in monitoring human breath and predicting breath modes (normal, fast, and deep breath), thereby expanding its potential applications in healthcare. This work opens up new avenues for using MJF‐printed wearable sensors for a variety of healthcare applications.