bluuebunny/crossref_metadata_2025_split huggingface dataset:
Modulatory Effects of Gingerol in Cancer Cell Growth Through Activation and Suppression of Signal Pathways in Cancer Cell Growth Systemic Review
Authors: Noor J Juvaid , Sindhu R. , Jothi A Banu , Prabu D , Mohan M Raj , Dhamodhar Dinesh , Fathima Lubna , Haripriya R 
Published: January 2025

ABSTRACT

Background:
Gingerol is a traditional medicinal herb used to treat various cancers. The current review aims to explore the modulatory effects of gingerol on cancer cell growth through the activation and suppression of key signaling pathways involved in cancer progression.

Methods:
A literature search was conducted on the databases such as PubMed, Cochrane, Google Scholar, and Embase. The inclusion criteria for the study were randomized control trials conducted during 2011–2023. Seven articles were selected for inclusion in the systematic review.

Results:
There was clinically significant evidence due to intervention in changes of nausea-related quality of life (QoL), overall chemotherapy-induced nausea and vomiting-related QoL, delayed nausea severity, fatigue, low incidence of malnutrition, and a high compliance rate. The findings of the study suggest that 6-gingerol hinders cell viability and induces cell death in prostate cancer cells, which is dependent on time and dose. 6-Gingerol could be developed as a complementary therapy to cisplatin in the management of ovarian cancer, offering a strategy to enhance therapeutic outcomes and minimize toxicity.

Conclusions:
This systematic review highlights the potential of ginger in malignancy treatment due to its ability to activate and suppress various signaling pathways. The review underscores the need for further in-depth studies and more clinical trials in humans to better understand the precise mechanisms and to validate the efficacy of ginger.
Comparative Study of Noncatheterized and Catheter-Associated Urinary Tract Infections by ESBL-Producing Gram-Negative Bacilli in an Urban Tertiary-Care Center, Salem, Tamil Nadu
Authors: Revathi KT , Rajan Reena , Mathavi S , Rao AV Raghavendra 
Published: January 2025

ABSTRACT

Background:
Urinary tract infections are frequently caused by Gram-negative bacilli, and timely detection and management of resistant strains and their antimicrobial susceptibilities are crucial.

Methods:
A six-month study examined Gram-negative bacilli from catheterized and noncatheterized patients, assessing antibiotic susceptibility, minimum inhibitory concentration, and Extended spectrum beta lactamase (ESBL) production genes using real-time Polymerase chain reaction (PCR).

Results:
Out of 72 isolates, 55.56% were ESBLs, with 65.0% from catheterized and 35.0% from noncatheterized samples. Out of 21 ESBL isolates, 47.62% had cefotaximase M (CTX-M) gene, while 4.76% had sulfhydril variant (SHV) and oxacillinase (OXA) 10/11 genes. Coproduction of CTX-M and SHV was observed.

Conclusion:
The study reveals multiple ESBL genes co-expression in clinical isolates from catheterized and noncatheterized patients, emphasizing the need for regular monitoring and antibiotic policy development.
Protective Effect of Triphala Mediated by H2S Signaling Pathway in LPS-Induced RAW Macrophages
Authors: Shanker Shyam Sundar , Dasgupta Tiasha , Hussain Sharmila , Annapoorni H , Tamizhselvi Ramasamy 
Published: January 2025

ABSTRACT

Introduction:
MacrophagesHydrogen sulfide (H2 S), an endogenously produced gasotransmitter, is a wellknown inflammatory agent production successfully controlled with triphala in macrophages.

Materials and method:
The ELISA analysis revealed that triphala extracts suppress the protein expression of NFκB (p65) and downregulation of the CSE gene expression. Moreover, in the presence of propargylglycine (PAG) the expression of NFκB and CSE gene was further reduced.

Results:
These results suggest that triphala could be a potent antiinflammatory effect that could be used for the treatment of many inflammatory disorders, including periimplantitis.
Vascular Inflammatory Genes as Predictors of Preeclampsia: A Systematic Review
Authors: Pogula Asha L. , Muthulakshmi R. , Thokali Srikanth , Pragathi Yatham , Periasamy Panneerselvam 
Published: January 2025

ABSTRACT

Background:
Preeclampsia, a condition causing new-onset hypertension and proteinuria after 20 weeks of gestation, is a significant cause of maternal and fetal morbidity and mortality. The pathogenesis of preeclampsia is complex, involving an interplay of vascular inflammation and angiogenic imbalance. This systematic review and meta-analysis aims to elucidate the role of key vascular inflammatory candidate genes—VEGF, TNF-α, IL-10, and LPL—in the onset of preeclampsia.

Methodology:
We conducted a comprehensive literature search across PubMed, Embase, and Cochrane databases, identifying case-control and cohort studies that examined the association between these genetic variants and preeclampsia.

Results:
Our meta-analysis reveals significant associations between preeclampsia and polymorphisms in the VEGF, TNF-α, IL-10, and LPL genes, with pooled odds ratios indicating increased risk for the VEGF -2578C>A, VEGF -1154G>A, TNF-α -308G>A, IL-10 -819C>T, and LPL Ser447Ter variants.

Conclusion:
These findings suggest that genetic predispositions in vascular inflammatory pathways may contribute to the development of preeclampsia, offering potential targets for early detection and therapeutic intervention. Further research is warranted to explore the molecular mechanisms by which these genetic variants influence the pathogenesis of preeclampsia and to develop targeted prevention strategies.
Comparative Evaluation of the New Angled Miniplate (Banana Plate) with the Conventional Miniplate for Management of Mandibular Angle Fracture
Authors: Bhavsar Keval , Sood Ramita , Mehta Tarang , Ludhwani Arpana , Makwana Sanjay , Attur Shylaja K. , Bhavsar Kinjal K. 
Published: January 2025

ABSTRACT

Introduction:
Mandibular angle fractures (MAFs) are divisive and have led to debate in terms of treatment. The study evaluated the new angled miniplate (banana plate) with the conventional miniplate for management of MAFs.

Patients and Methods:
The study included 53 patients of MAFs, 26 treated with the conventional miniplate (control group) and 27 with the angled miniplate (study group). The patients were followed up and evaluated for 6 months for mouth opening, bite force, and complications.

Results:
A longer operating time was noted in the study group. The mouth opening and bite force were higher in the study group with fewer postoperative complications.

Conclusion:
The new angled miniplate mimics the angle of the mandible and offers better tridimensional stability, fewer complications, and improved stability.
Evaluation of the Anticandidal Effect of Medicinal Plant Extracts to Drug Resistant Candida Albicans Isolates from Type Two Diabetic patients with Stage Three Periodontitis
Authors: Prabhakaran Jayachandran V. , Varghese Nibu , Rupesh S , Thomas Annie Susan , Sameer KM , Thomas Nebu George 
Published: January 2025

ABSTRACT

Objectives:
To assess the anticandidal efficacy of nine medicinal plants to drug resistant Candida albicans isolates from diabetic patients with chronic periodontitis. A comparison was done with chlorhexidine gluconate.

Methods:
Isolates from the periodontal pockets of 121 diabetics with severe periodontitis was obtained. Sensitivity to four antifungal antibiotics was assessed by disc diffusion method. Anticandidal activity of cold ethanol and hot aqueous extracts of nine plants were evaluated by well diffusion method. Minimum inhibitory concentration (MIC) was determined by microtube broth dilution method.

Results:

C. albicans was found to be the predominant species. None of the isolates extended resistance to amphotericin B. Aqueous and ethanol extracts of Punica granatum, Terminalia bellerica, Terminalia chebula extended notable anticandidal efficacy, and the ethanol extracts were more active. Chlorhexidine extended better efficacy than the plant extracts.

Conclusions:

C
albicans is the prevalent yeast among diabetics with periodontitis. Presence of multidrug resistant for C. albicans is a challenge. P. granatum, T. bellerica and T. chebula can be explored for the development of safer anticandidal agents.
Assessing the Impact of Skin Tone on Tooth Shade Selection: A Cross-Sectional Study
Authors: Rai Priyanka , Anusha Gattu , Rathore Kiran Kunwar , Kumar Vimal , Rajitha Reddy K. , Kodati Sanjana 
Published: January 2025

ABSTRACT

Background:
The role of skin tone in determining tooth shade preferences is crucial in aesthetic dentistry. This study aims to evaluate the impact of skin tone on tooth shade selection by comparing preferences between dental professionals and laypersons.

Methods:
A cross-sectional study was conducted with 100 participants, including 50 dental specialists (prosthodontists and endodontists) and 50 laypersons (teachers, engineers, and business owners). Participants were presented with a randomized slideshow of 15 modified images featuring a woman with varying skin tones (fair, medium, dark) and tooth shades (from 00 to 04). Each image was rated on a scale from 1 (Very unattractive) to 4 (Very attractive).

Results:
There were no statistically significant differences in the ratings of dental appearance across different skin tones between dental professionals and laypersons. For fair skin, medium skin, and dark skin tones, the mean scores assigned by both groups were statistically indistinguishable (P > 0.05).

Conclusion:
The study indicates that both dental professionals and laypersons converge in their tooth shade preferences related to skin tone, despite their different backgrounds. This suggests a shared perspective on dental aesthetics and highlights the importance of aligning aesthetic treatments with general preferences.
Translation and Validation of Rating-of-Fatigue Scale to be Used in Nonsurgical Endodontic Re-treatment
Authors: Mustufa Chawre , Ghani Huwaina Abd , Nayak Moksha , Khamis Mohd Fadhli , Ariffin Zaihan , Rahman Normastura Abd 
Published: January 2025

ABSTRACT

Background:
This study aimed to translate and validate the rating-of-fatigue (ROF) scale in the Kannada language.

Methods:
This current study involved two steps, where forward translation, backward translation, cross-cultural adaptation, and test of a pre-final version of the ROF scale were conducted in the first step. Content validity, face validity, and construct validity of the ROF scale were performed in five stages. This study enlisted the help of eight experts to create the ROF scale in the Kannada language. Moreover, 50 patients participated by responding to a variety of Likert scale and numeric scale questionnaires that surveyed the intention of measuring the ROF scale. The content validity and face validity were assessed by using the index prepared for the content validity and face validity, respectively, along with mean and standard deviation (SD). The correlation between the Kannada version of the ROF measure and a numerical rating scale-facial rating scale (NRS-FRS) was assessed by the Pearson’s correlation coefficient (PCC). Moreover, a comparison of the mean value of ROF and NRS-FRS was performed by the paired t-test.

Results:
The Kannada version of the ROF scale was prepared after getting consensus from all the experts. The fatigue questionnaire met a high level of expert content validity (0.93) and showed that most experts opined high relevance (1.00) for measuring dental fatigue. The fatigue questionnaire meets a high level of response in face validity (0.92) based on the face validity indices. PCC showed a high level of construct validity (r = 0.819) of the ROF scale. No significant difference (P = 0.858) was observed between ROF and NRS-FRS by the paired t-test.

Conclusion:
The Kannada version of the ROF scale is a valid tool to assess dental fatigue.
A Comparative Study of Euthyroid and Primary Hypothyroid Patients in End Stage Renal Disease (ESRD) Undergoing Maintenance Hemodialysis (MHD) in a Tertiary Care Hospital in Salem, Tamil Nadu
Authors: Vijayasamundeeswari Chinnathambipalayam Kandasamy , Jayachandrababu Byna , Kundu Sandip Kumar , Parhi Kamala Kanta , Ronald P. Jones , Periasamy Panneerselvam 
Published: January 2025

ABSTRACT

Background and Aim:
Hypothyroidism significantly alters renal function. Still, there are few scientific studies on thyroid disorders and how it influences renal function. Recent research suggested hypothyroidism may lower the glomerular filtration rate. This study aimed to assess changes in renal function biochemical parameters in MHD patients with primary hypothyroidism.

Methods:
132 patients with MHD participated in a prospective research who had untreated primary hypothyroidism and euthyroidism. Immunoassay was used to quantify thyroid-stimulating hormone (TSH), free thyroxine (fT4), and free triiodothyronine (fT3). Renal parameters; urea and creatinine were measured in fully automated biochemical analyzer and estimated glomerular filtration rate (eGFR) was calculated by the Modification of Diet in Renal Disease (MDRD) formula.

Results:
In comparison with euthyroid MHD patients with primary hypothyroid MHD patients have higher significant values of TSH, creatinine, SBP, DBP as 3.57 ± 1.15 vs 10.49 ± 6.40, 8.23 ± 2.40 vs 9.31 ± 2.49, 155.87 ± 5.84 vs 162 ± 6.82, 91.73 ± 6.14 vs 98.64 ± 6.28. The fT4, fT3 and eGFR value reduced significantly in primary hypothyroid MHD patients as compared to euthyroid MHD patients as 1.10 ± 0.24 to 0.44 ± 0.21, 2.65 ± 0.89 to 1.13 ± 0.24 and 6.82 ± 2.5 to 5.40 ± 1.66, respectively.

Discussion:
Our study demonstrated that in primary hypothyroid patients due to increase of SBP and DBP glomerular feedback is increased as a result creatinine excretion decreased. So GFR decreased leads to decreased iodine clearance and can cause decreased synthesis of thyroid hormones leading to primary hypothyroidism in MHD patients.

Conclusions:
Thyroid dysfunction is linked to impaired kidney function, making it crucial for clinicians to understand this connection in patients with multiple myeloma (MHD), and monitoring creatinine is essential.
Nano Phosphorylated Pullulan-Integrated Carboxymethyl Chitosan Scaffold for Regeneration of the Pulp-Dentin Complex: An In vitro Study
Authors: Sornamalar M , Dhanavel C , Balavaishnavi G , Shajahan Shahana , Baskar Kavya , Raja S Vijaya 
Published: January 2025

ABSTRACT

Background:
To optimize a novel composite scaffold comprising of nano phosphorylated pullulan incorporated carboxymethyl chitosan (nPP-CMC) and to evaluate its cell viability and proliferation in human dental pulp stem cells (hDPSCs).

Methodology:
Nano phosphorylated pullulan (nPP) in concentrations of 200 mg, 400 mg, 600 mg, 800 mg, and 1 g was vortexed in 20 mL of distilled water, followed by 30 mins of ultrasonication for even dispersion. 1 g of CMC was added to each nPP mixture, blended for 1 hour to form a hydrogel, and freeze-dried for 18 hours at -20°C to yield nPP-CMC scaffolds in ratios of 1:5, 2:5, 3:5, 4:5, and 1:1. These scaffolds were stored at room temperature. The scaffolds were characterized using SEM-EDX, FT-IR, and XRD. The optimized nPP-CMC (group 1), CMC (group 2), and osteogenic medium (group 3) were tested for cell viability with hDPSCs using the MTT assay at 0, 7, 14, and 21 days.

Results:
Based on the results of MTT assay, the cell viability and proliferation of nPP-CMC scaffold was comparable to that of CMC in the tested time intervals of 7 and 14 days. The 4:5 nPP-CMC revealed a favourable pore size (60–180 μm) that was suitable for cell seeding and was chosen for further experiments. Cell viability/proliferation rates of hDPSCs loaded 4:5 HAnp- CMC at 21st day was significantly greater than that at 7th day (P < .05).

Conclusion:
Hence, within the limitations of this in vitro study, it could be concluded that the novel experimental scaffold comprising of nPP-CMC (4:5) is an effective biomaterial that possess good bioactivity and biocompatibility properties. Thus, nPP-CMC biomaterial will have a great futuristic potential for regeneration of pulp dentin complex.
Investigation of Antimicrobial and Antioxidant Properties of Tamarix nilotica (Ehrenb.) Bunge Leaf Extract Against Catheter-Associated Urinary Tract Infections (CAUTIs) in Al Kharj Governorate
Authors: Poyil Muhammad Musthafa , Alsharif Mohammed H Karrar , Arafah Abdullah Mohammed Radwan 
Published: January 2025

ABSTRACT

Introduction:
One of most important nosocomial infections, Catheter associated urinary tract infections (CAUTI) are caused by many biofilms forming organism which makes treatment challenges as well as resistant strain development. To prevent the CAUTI, the new antimicrobials are needed immediately.

Methodology:
The overnight grown cultures such as S. aureus, P. aeruginosa, and C. albicans were grown in Brain Heart Infusion (BHI) broth, Mueller Hinton Broth (MHB), and Sabouraud Dextrose Broth (SDB). Ampicillin, rifampicin, and nystatin were used in all the experiments as positive controls and also, methanol was used as vehicle control.

Results:
The T. nilotica leaf extract showed antimicrobial activity at 2 mg/ml against S. aureus and 1 mg/ml against P. aeruginosa and C. albicans. Further, crystal violet staining revealed, T. nilotica antibiofilm activity through biofilm inhibition and also, it was efficiently eliminated 77%, 73%, and 78% of S. aureus, P. aeruginosa and C. albicans mature biofilms individually. Later, catheter coating with leaf extract explored strong antimicrobial activity against tested pathogens in in vitro bladder model. In addition, T. nilotica leaf extract expressed strong antioxidant property.

Conclusion:

T. nilotica can be considered as alternative antimicrobial agent for CAUTI treatment.
Anti-Caries Activity of New Generation Rechargeable Dental Composites – An In Vitro Study
Authors: Savita Anjali , Verma Yashvi , Dubey Vertika , Dubey Priyanka , Najam Ayesha , Luhana Rinkal 
Published: January 2025

ABSTRACT

Introduction:
Secondary caries at the restorative margins is the common reason for dental composite restoration failure. Our objectives were to evaluate the anti-caries activity of new generation rechargeable composites and to evaluate three different concentrations of quaternary ammonium methacrylate compound on S. mutans biofilm.

Material and Methods:
The composite resin consisted of urethane dimethacrylate and triethylene glycol divinylbenzyl ether and was prepared with 2%, 5%, and 8% of dimethylaminohexadecyl methacrylate (DMAHDM) and 20% of nanoparticles of amorphous calcium phosphate for remineralization.

Result:
It was found that the incorporation of 8% DMAHDM significantly reduced S. mutans biofilm colony-forming units by 2–5 log by 7 folds, compared to the composite with 2% DMAHDM (P < 0.05) and nonsignificantly to 5% group. Adding 5% DMAHDM provides sustained Ca and P ion release as compared to 2% and 8% groups.

Concusion:
Hence, it was concluded that the composite with DMAHDM content increased the antibacterial effect in a dose-dependent manner and provided sustained Ca and P ion release till 70 days.
GC-MS Analysis of the Ayurvedic Oil Balaswagandhadi Tailam
Authors: Sudhan Aparna , Prabhu K , Jones Sumathi , Janaki CS , Sheriff Dhastagir , Rao Mudiganthi Ramakrishna , Muttevi Hayagreva Kumar , Balakrishnan Deepalakkshmi , Sivanesh M 
Published: January 2025

ABSTRACT

Background:
To evaluate the efficacy of alternative medications such as Ayurveda, Sidha, and Unani, the application of advanced analytical tools is essential.

Aim:
In this study, the Ayurvedic oil Balaswagandhadi tailam, which is prescribed for treating fever, muscle weakness, bone and joint issues, muscle wasting, arthritic pain, neuralgia, and paralysis.

Methods:
The presence of active component was analyzed using gas chromatography–mass spectrometry (GC-MS) following a prescribed protocol.

Results:
The GC-MS study disclosed the presence of several essential bioactive compounds, including trans-2-methyl-4-n-pentylthiane, S, S-dioxide, chloroacetic acid, tetradecyl ester, 1,2-benzenedicarboxylic acid, bis(2-methylpropyl) ester, methyl 12,15-octadecadienoate, 11-octadecenoic acid, methyl ester, cis-10-heptadecenoic acid, tetradecanedioic acid, 15-hydroxypentadecanoic acid, octadecanoic acid, levo-menthoxyacetic acid, β-eudesmol trimethylsilyl ether, 1-heptatriacotanol, vitamin E, campesterol, and γ-sitosterol.

Conclusion:
The compounds identified are known for their various medicinal properties, potentially contributing to the therapeutic effects of Balaswagandhadi tailam. Further research is warranted to explore these findings.
Prevalence of Gastritis among Morbidly Obese Patients Subjected to Laparoscopic Sleeve Gastrectomy at a Tertiary Hospital, Makkah, Saudi Arabia
Authors: Alshehri Adel , Alkashgry Sarah , Alzahrani Fadhel , Elbahrawy Aly 
Published: January 2025

ABSTRACT

Background and Objective:
Morbidly obese persons often get gastritis after laparoscopic sleeve gastrectomy (LSG). The study examined the prevalence of gastritis and associated risk factors after LSG at a tertiary hospital in Saudi Arabia.

Materials and Methods:
The present retrospective cross-sectional study comprised patients with obesity aged 18 and older who received LSG between 2019 and 2023. Pre- and post-operative gastritis symptoms, results, and risk factors were examined.

Results:
The study involved 343 patients. Gastritis was common after LSG, affecting 70.3% of patients. Gastritis was approximately twice as likely in women as in men. Hypothyroidism and cesarean section history increased gastritis risk by five-fold and three-fold, respectively. H. pylori infection increased the risk of gastritis seventeen-fold after surgery.

Conclusion:
Significant risk variables were female gender, hypothyroidism, cesarean section history, and H. pylori infection.
Oral Health Behavior and Tobacco Usage of Coal Mine Workers in Tamil Nadu
Authors: Pillai Dinesh Dhamodharan Mathavan , Palaneeswaran Kamalashankar , Ravichandran Kathiresan , Jayaraj Merlin , Iyyaparaj P , Thirumurugan K , Nagappan Nagappan , Sekar Gowrishankar 
Published: January 2025

ABSTRACT

Background:
Health behavior is widely influenced by behavior, attitudes, and knowledge, which impacts oral health. Mostly, individuals with poor oral hygiene have been found to be consuming more sugar.

Aim:
The present study aims to assess the behavioral practices and tobacco usage of coal mine workers in Tamil Nadu towards oral health.

Materials and Methods:
A simple random sampling technique was employed to recruit 309 Mine I workers and 294 Mine II workers. A pre-tested questionnaire was used to collect data pertaining to oral health-related behavior and oral hygiene practices.

Results:
Cigarette and bidi smoking were found in most of the workers. In both Mine I and Mine II, the majority of the subjects used tooth brushes and toothpaste for cleaning their teeth (78.6% and 76.5%, respectively). In Mine I, 58 (18.8%) subjects used finger and tooth powder for cleaning their teeth, while 6 (2%) used finger and toothpaste, and two tooth brush and powder. In Mine II, it was 52 (17.7%), 7 (2.4%), and 10 (3.4%), respectively.

Conclusion:
89.7% of Mine I workers had cleaned their teeth once daily. In Mine I, the subjects who used finger and tooth powder for cleaning their teeth were 18.8%, those using finger and toothpaste were 2%, and tooth brushes and powder were 0.6%.