bluuebunny/crossref_metadata_2025_split huggingface dataset:
Toward sustainability? Contributions of the Guatemalan Sugarcane Agro‐Industry to the Sustainable Development Goals on water and energy
Authors: Salazar Luis Fernando , Guerra Noriega Alex , Bolaños Andrea , Solís Juan Pablo 
Published: October 2023

AbstractSustainability is a global mandate and has set agendas for regions, nations, sectors, and corporations. Because of the globalized nature of the economy, the pursuit of sustainability in one place has implications for others. The aim of this paper is to describe how a sector—the Guatemalan Sugarcane Agro‐industry (GSAI)—can make progress toward sustainability and contribute to the Sustainable Development Goals of the country in which it operates. The methodology used was a case study description, based largely on data reported by the GSAI. The main findings of the study show that the contributions of the industry to water and sanitation in its area of operations have been important, but limited, due to several factors that include issues such as: lack of political will, lack of technical capacity, financing, and appropriate legislation. On the other hand, the contributions of the GSAI to energy have been remarkable for the Guatemalan energy matrix, highlighting that cogeneration from sugarcane bagasse represents up to 30% of the electricity demand in the country during the 6‐month harvest season. Building on social corporate responsibility theory, the actions related to the goals on water and energy are explained. What was found is that the contributions of a sector, though important, are possibly not outstanding at the national scale, and that the conditions of the country limit the reach or pace of progress of the sector. An exception is the contributions toward sustainable energy and associated emissions, which are noteworthy. The interplay of actors at different scales needs to be understood if globally we are to achieve the goals. This understanding is key to put in place policies and enabling conditions for sectors to make progress faster, helping their country advance as well as contributing to sustainability of buyers in other countries or regions.
Characterisation of the growth behaviour of Listeria monocytogenes in Listeria synthetic media
Authors: Schulz Lisa Maria , Konrath Alicia , Rismondo Jeanine 
Published: October 2023

AbstractThe foodborne pathogen Listeria monocytogenes can grow in a wide range of environmental conditions. For the study of the physiology of this organism, several chemically defined media have been developed over the past decades. Here, we examined the ability of L. monocytogenes wildtype strains EGD‐e and 10403S to grow under salt and pH stress in Listeria synthetic medium (LSM). Furthermore, we determined that a wide range of carbon sources could support the growth of both wildtype strains in LSM. However, for hexose phosphate sugars such as glucose‐1‐phosphate, both L. monocytogenes strains need to be pre‐grown under conditions, where the major virulence regulator PrfA is active. In addition, growth of both L. monocytogenes strains was observed when LSM was supplemented with the amino acid sugar N‐acetylmannosamine (ManNAc). We were able to show that some of the proteins encoded in the operon lmo2795‐nanE, such as the ManNAc‐6‐phosphate epimerase NanE, are required for growth in the presence of ManNAc. The first gene of the operon, lmo2795, encodes a transcriptional regulator of the RpiR family. Using electrophoretic mobility shift assays and quantitative real‐time PCR analysis, we were able to show that Lmo2795 binds to the promoter region of the operon lmo2795‐nanE and activates its expression.
Clinical characteristics and treatment outcomes of HER2 mutation and HER2 fusion in 22 patients with advanced breast cancer
Authors: Mu Yuxin , Meng Yanchun , Du Yiqun , Liu Xiaojun , Zhang Jian 
Published: October 2023

AbstractBackgroundThe clinical characteristics and efficacy of human epidermal growth factor receptor‐2 (HER‐2)‐directed agents against HER2 mutations and HER2 fusions in breast cancer are obscure due to their low frequency.MethodsWe conducted a retrospective study in patients with advanced breast cancer harboring HER2 mutations and/or HER2 fusions between January 1, 2017 and January 1, 2021.ResultsAmong a total of 22 patients, 17 HER2 mutations were detected, including L755S, S310F, R100=, V777L, R897W, T862A, 440‐17C > G, H878Y, V842I, 73 + 9G > C, T278fs, E1069K, L755P, 226‐11C > T, 574 + 12C>T, L114V and P128L. The majority of patients had ductal carcinoma, which mostly coexisted with HER2 amplification/overexpression. The median progression‐free survival (PFS) of the 22 patients was 6.9 months (95% CI: 4.7, 9.1) in the first‐line setting. The median PFS of patients who received first‐line trastuzumab‐based regimens was significantly longer than that of patients who received a first‐line tyrosine kinase inhibitor (TKI) (10.8 months [95% CI: 2.9, 18.7] vs. 1.9 months [95% CI: 0.8, 3.0], p < 0.005). A total of 14 patients were treated with anti‐HER2 antibody‐drug conjugate (ADC), among whom the median treatment line of first‐time of administration of anti‐HER2 ADC was 4.5 (range, 1–10). Anti‐HER2 ADC reached an objective response rate (ORR) of 42.9%, a disease control rate (DCR) of 85.7% and a median PFS of 7.3 months (95% CI: 4.4–10.1) from the first‐time of administration.ConclusionOur data demonstrated the clinical benefit of anti‐HER2 treatment in Chinese breast cancer patients harboring HER2 mutation and/or HER2 fusion. The value of immunotherapy and treatment selection among individual HER2 variants needs further study.
How does economic inequality shape conspiracy theories? Empirical evidence from China
Authors: Zeng Zhao‐Xie , Tian Cai‐Yu , Mao Jia‐Yan , van Prooijen Jan‐Willem , Zhang Yue , Yang Shen‐Long , Xie Xiao‐Na , Guo Yong‐Yu 
Published: October 2023

AbstractConspiracy theories tend to be prevalent, particularly in societies with high economic inequality. However, few studies have examined the relationship between economic inequality and belief in conspiracy theories. We propose that economic inequality leads people to believe conspiracy theories about economically advantaged groups (i.e., upwards conspiracy theories) and that moral evaluations of those groups mediate this relationship. Study 1 (N = 300) found support for these ideas in a survey among Chinese residents. Study 2 (N = 160) manipulated participants' perceptions of economic inequality in a virtual society. The manipulation shaped moral evaluations of economically advantaged groups, and conspiracy beliefs, in the predicted manner. In Study 3 (N = 191) and Study 4 (N = 210), we experimentally manipulated participants' perceptions of economic inequality in real Chinese society and replicated the results of Study 2. In addition, in Study 4, we find that economic inequality predicts belief in conspiracy theories about economically disadvantaged groups (i.e., downward conspiracy theories), which was mediated by anomie. We conclude that perceived economic inequality predicts conspiracy theories about economically advantaged groups and that moral evaluations account for this effect. Also, upward and downward conspiracy theory beliefs are associated with different psychological processes.
Ethnic sensitivity assessment: Polatuzumab vedotin pharmacokinetics in Asian and non‐Asian patients with previously untreated diffuse large B‐cell lymphoma in POLARIX
Authors: Liao Michael Z. , Deng Rong , Gibiansky Leonid , Lu Tong , Agarwal Priya , Dere Randall , Lee Calvin , Hirata Jamie , Herbaux Charles , Salles Gilles , Li Chunze , Miles Dale 
Published: October 2023

AbstractThis ethnic sensitivity analysis used data from the phase III POLARIX study (NCT03274492) to assess polatuzumab vedotin pharmacokinetics (PKs) in Asian versus non‐Asian patients with previously untreated diffuse large B‐cell lymphoma and examined the appropriateness of extrapolating global study findings to Asian patients. PK and population PK (PopPK) analyses assessed polatuzumab vedotin analyte exposures by ethnicity (Asian [n = 84] vs. non‐Asian [n = 345] patients) and region (patients enrolled from Asia [n = 80] vs. outside Asia [n = 349]). In patients from Asia versus outside Asia, observed mean antibody‐conjugated monomethyl auristatin E (acMMAE) concentrations were comparable (1.2% lower at cycle [C]1 postdose, 4.4% higher at C4 predose; and 6.8% lower at C4 postdose in patients from Asia). Observed mean unconjugated MMAE was lower in patients from Asia by 6.5% (C1 postdose), 20.0% (C4 predose), and 15.3% (C4 postdose). In the PopPK analysis, C6 area under the curve and peak plasma concentrations were also comparable for acMMAE (6.3% and 3.0% lower in Asian vs. non‐Asian patients, respectively) and lower for unconjugated MMAE by 19.1% and 16.7%, respectively. By region, C6 mean acMMAE concentrations were similar, and C6 mean unconjugated MMAE concentrations were lower, in patients enrolled from Asia versus outside Asia, by 3.9%–7.0% and 17.3%–19.7%, respectively. In conclusion, polatuzumab vedotin PKs were similar between Asian and non‐Asian patients by ethnicity and region, suggesting PKs are not sensitive to Asian ethnicity and dose adjustments are not required in Asian patients to maintain efficacy and safety.
Risk of ankylosis of avulsed teeth immediately replanted or stored under favorable storage conditions before replantation: A long‐term clinical study
Authors: Gul Abdulaziz , Lauridsen Eva , Gerds Thomas A. , Andersson Lars 
Published: October 2023

AbstractBackground/AimThere are few long‐term clinical follow‐up studies on human teeth replanted immediately or after storage in a suitable storage medium prior to replantation. This study aimed to assess the risk of ankylosis in avulsed human teeth replanted immediately or after storage in physiological media for a short time.MaterialData from 116 patients with 145 replanted avulsed permanent teeth were selected from a comprehensive dental trauma database in Copenhagen University Hospital. The following teeth were selected: Group 1 comprised 36 teeth replanted immediately (dry time <6 min; wet time <6 min). Group 2 comprised 61 teeth replanted after physiologic storage media (saliva and saline) (dry time <6 min; wet time >5 min; wet time ranged from 7 to 170 min, and mean wet time was 59 min). Group 3 (control) included 48 teeth replanted after dry storage (dry time > 60 min).MethodClinical and radiographic registrations were carried out according to a standardized protocol; follow‐up ranged from 7 months to 23 years. Ankylosis was diagnosed by percussion test and radiographs and related to the conditions prior to replantation and stage of root development.ResultsThe overall risk of ankylosis was 17.2% [95% CI: 4.61; 29.79] for immediately replanted teeth, 55.3% [95% CI: 42.54; 68.00] for teeth stored in physiologic media before replantation, and 85.7% [95% CI: 75.70; 95.73] for teeth stored dry more than 1 h. Mature teeth showed a significantly higher risk of ankylosis than immature teeth.ConclusionThis clinical long‐term study has verified earlier experimental studies showing that immediate reimplantation has the lowest risk of ankylosis. Physiologic storage media are good alternatives that also reduce the risk of ankylosis compared to dry storage, where ankylosis is more likely although not always seen. Mature teeth are significantly more likely to develop ankylosis.
Parent–child gender effect in the associations among problematic internet use, parent–adolescent conflict, and academic engagement
Authors: Liu Sihan , Ying Jiefeng , Wang Xinyi , Shi Jialin , Wu Xinchun 
Published: October 2023

AbstractObjectiveIn this study, we explored whether and how the indirect effects of father– and mother–adolescent conflict between PIU and academic engagement differ between female and male adolescents.BackgroundProblematic internet use (PIU) is an important health issue for adolescents. It has been found to be related to severe impairment in their interpersonal relationships (e.g., parent–child relationships) and academic outcomes (e.g., academic engagement), particularly during the COVID‐19 pandemic.MethodA national survey was conducted in diverse regions of the Chinese mainland, and a total of 2,688 adolescents between 10 and 19 years old (52.8% girls, Mage = 14.06 ± 2.47) participated in the study. Correlation and mediation analyses were conducted and were stratified by gender.ResultsMultigroup analysis indicated that PIU was similarly and positively associated with father– and mother–adolescent conflict in adolescent boys and girls, whereas only father–adolescent conflict was negatively related to boys’ academic engagement and only mother–adolescent conflict was negatively related to girls’ academic engagement.ConclusionThese results support the same‐gender matching model in parent–adolescent conflict and expand the same‐gender effect to Chinese culture.ImplicationsThese findings have important implications for understanding the mechanisms of how adolescent PIU impedes academic engagement through parent–adolescent conflict in father–son, father–daughter, mother–son, and mother–daughter dyads, indicating that family interventions focused on father–son and mother–daughter relationships may largely facilitate adolescents’ academic engagement.
Association of mean RDW values and changes in RDW with in‐hospital mortality in ventilator‐associated pneumonia (VAP): Evidence from MIMIC‐IV database
Authors: Nan Wenbin , Li Siqi , Wan Jinfa , Peng Zhenyu 
Published: October 2023

AbstractIntroductionVentilator‐associated pneumonia (VAP) is a hospital‐acquired infection with high mortality, and remains a challenge for clinical treatment. Red blood cell distribution width (RDW) was associated with worse outcomes in several diseases. The purpose of this study was to investigate the relationship between mean RDW values, changes in RDW (delta RDW), and in‐hospital mortality among patients with VAP.MethodsIn the present study, we enrolled 1266 VAP patients from the Medical Information Mart for Intensive Care IV (MIMIC‐IV) database. All patients were categorized into low group, medium group, and high group according to tertiles of mean RDW values. The primary outcome was all‐cause in‐hospital mortality. Univariate logistic regression analysis, multivariate logistic regression analysis, and restricted cubic spline (RCS) curve were performed to determine the association between mean RDW values and in‐hospital mortality in VAP. Moreover, RCS curve was plotted to explore the dose–response relationship between delta RDW and in‐hospital mortality in VAP.ResultsAmong the VAP patients included in the study, the in‐hospital mortality was 20.85% with 264 non‐survivors and 1002 survivors. The non‐survivors exhibited significantly higher mean RDW values and delta RDW values compared to survivors. Multivariate logistic regression analysis indicated that mean RDW values were positively associated with in‐hospital mortality in VAP after adjusting for relevant covariates. The RCS curve demonstrated a dose–response relationship between mean RDW and the mortality in VAP. Moreover, a linear relationship was observed between delta RDW and in‐hospital mortality in VAP.ConclusionHigher mean RDW values were significantly associated with an increased risk of in‐hospital mortality in VAP. Additionally, a linear relationship was found between delta RDW values and in‐hospital mortality. These findings suggest that RDW can be used to identify high‐risk patients with poorer outcomes in VAP.
Helpfulness of online customer reviews for shopping goods and services: The perspective of signalling theory
Authors: Chu My Giang , Lin Yu‐Hsun , Le Tram Dinh Thi , Phan Quyen Phu Thi , Van Thao Nguyen 
Published: October 2023

AbstractTo help customers get quality feedback from the huge number of online reviews, online retailers attempt to generate evaluations from consumers of how helpful product reviews are. Drawing on signalling theory, this study proposes a comprehensive model to examine the influence of factors related to the reviewer (signaller), the review (signal) and the users (readers of the signal) on online review helpfulness via e‐commerce sites and apps. This study also includes the moderating role of product categories (goods/services) in the model. Data were collected from 466 Vietnamese respondents. Using a Smart Partial Lease Square 3.0, the outcomes indicate that online review information quality, online reviewer information credibility and two dimensions of receivers (e.g. users’ attitudes towards information and information task‐fit) all have a significant influence on online review helpfulness; however, users’ need for information has no impact on the helpfulness of online reviews. Interestingly, the product type (goods vs services) has a moderating effect between online review information quality/attitude towards information and online review helpfulness. This study contributes significantly to signalling theory and online review helpfulness by comprehensively incorporating three attributes that are paramount to online reviews: the review, the reviewer and the users. Additionally, the information is enriched by the investigation of the moderating effect of product categories (goods vs services) on the context of online review helpfulness.
A tRF‐5a fragment that regulates radiation resistance of colorectal cancer cells by targeting MKNK1
Authors: Huang Tianyi , Chen Chujia , Du Juan , Zheng Zhen , Ye Shuang , Fang Shuai , Liu Kaitai 
Published: October 2023

AbstractRadiotherapy serves as a crucial strategy in the treatment of colorectal cancer (CRC). However, its efficacy is often hindered by the challenge of radiation resistance. Although the literature suggests that some tRNA‐derived small RNAs (tsRNAs) are associated with various cancers, studies reporting the relationship of tsRNAs with cancer cell radiosensitivity have not been published yet. In our study, we utilized tsRNAs sequencing to predict differentially expressed tsRNAs in two CRC cells and their radioresistant cells, and 10 tsRNAs with significant differences in expression were validated by qPCR. The target genes of tRF‐16‐7X9PN5D were predicted and verified by the bioinformatics, dual‐luciferase reporter gene assay and western blotting analyses. Wound healing, colony formation, transwell invasion and CCK‐8 assays were performed to detect the effects of tRF‐16‐7X9PN5D on cell function and radiosensitivity. Western blotting evaluated the relationship between tRF‐16‐7X9PN5D and the MKNK‐eIF4E axis. Our findings demonstrated that tRF‐16‐7X9PN5D expression was substantially downregulated in radioresistant CRC cells. Furthermore, tRF‐16‐7X9PN5D could promote CRC cells' ability to proliferate, migrate, invade and obtain radiation resistance by targeting MKNK1. Finally, tRF‐16‐7X9PN5D could regulate eIF4E phosphorylation via MKNK1. This investigation indicated that tRF‐16‐7X9PN5D has an essential regulatory role in the radiation resistance of CRC by directly targeting MKNK1, and may be a new pathway for regulating the CRC radiosensitivity.
A novel approach for sterilization and concentration of traditional functional drinks: Membrane‐based nonthermal processes
Authors: Meutia Fahliza , Wijaya C. Hanny , Julian Helen 
Published: October 2023

AbstractThe applicability of microfiltration (MF) and osmotic membrane distillation (OMD) for sterilization and concentration of traditional functional drink constituents, such as Curcuma xanthorrhiza, ginger, lime, Java tea, and sappan wood extracts, was evaluated in this study. MF showed excellent performance in microorganisms elimination, turbidity reduction, and maintaining antihyperglycemic activity performance. However, a reduction of total phenol and antioxidant activity were observed due to the retention by MF. Fouling in MF was challenging and resulted in rapid flux decline. The concentration of sterilized extracts by OMD operation resulted in a concentration factor of 1.15, 1.13, 1.10, 1.24, and 1.24 for ginger, lime, C. xanthorrhiza, Java tea, and sappan wood, respectively. The active compounds were well preserved, with a maximum of 20% reduction compared to sterilized extracts. Despite insignificant foulant deposition, the OMD flux in tests using C. xanthorrhiza, ginger, and lime as the feed decreased over time, indicating reduced driving force.Practical applicationsThe application of membrane technology for juices and liquid foods sterilization and concentration has been widely researched. In this research, we evaluated the performance of MF and OMD for the sterilization and concentration of traditional functional drinks. The results indicated that the functional drink can be sterilized by MF with excellent preservation of the active compounds, such as those responsible for the antihyperglycemic and antioxidant activities. The OMD could also concentrate the traditional functional drink, even though concentration polarization posed a challenge to flux stability. The degradation of phenolic compounds and antioxidant activity of the concentrated traditional functional drink was at a minimal value, indicating the promising application of MF and OMD. We believe this article provides new and exciting insights to push forward the sterilization and concentration process in industrial scale.
Focal acetylcholinergic modulation of the human midcingulo‐insular network during attention: Meta‐analytic neuroimaging and behavioral evidence
Authors: Chakraborty Sudesna , Lee Sun Kyun , Arnold Sarah M. , Haast Roy A. M. , Khan Ali R. , Schmitz Taylor W. 
Published: October 2023

AbstractThe basal forebrain cholinergic neurons provide acetylcholine to the cortex via large projections. Recent molecular imaging work in humans indicates that the cortical cholinergic innervation is not uniformly distributed, but rather may disproportionately innervate cortical areas relevant to supervisory attention. In this study, we therefore reexamined the spatial relationship between acetylcholinergic modulation and attention in the human cortex using meta‐analytic strategies targeting both pharmacological and non‐pharmacological neuroimaging studies. We found that pharmaco‐modulation of acetylcholine evoked both increased activity in the anterior cingulate and decreased activity in the opercular and insular cortex. In large independent meta‐analyses of non‐pharmacological neuroimaging research, we demonstrate that during attentional engagement these cortical areas exhibit (1) task‐related co‐activation with the basal forebrain, (2) task‐related co‐activation with one another, and (3) spatial overlap with dense cholinergic innervations originating from the basal forebrain, as estimated by multimodal positron emission tomography and magnetic resonance imaging. Finally, we provide meta‐analytic evidence that pharmaco‐modulation of acetylcholine also induces a speeding of responses to targets with no apparent tradeoff in accuracy. In sum, we demonstrate in humans that acetylcholinergic modulation of midcingulo‐insular hubs of the ventral attention/salience network via basal forebrain afferents may coordinate selection of task relevant information, thereby facilitating cognition and behavior.image