bluuebunny/crossref_metadata_2025_split huggingface dataset:
Therapeutic Potential of Manuka Honey Microbubble Dressing in Wound Management
Authors: Lin Pei‐Ju 
Published: February 2025

AbstractThis study investigates the antibacterial effects of Manuka honey (MH) microbubbles on Staphylococcus aureus (S. aureus) in wound dressings. MH solutions are passed through a microbubble generator with a high‐density stainless steel mesh nozzle to produce MH‐containing microbubbles, which are then injected into dressings in contact with S. aureus. The experiment examines variables including microbubble particle sizes, dressing types, MH microbubbles consumption, and antibacterial action durations. Statistical analyses are performed on colony survival rates under various conditions. Results indicate that MH microbubble characteristics, MH microbubbles consumption, and action duration indirectly enhance S. aureus elimination, with overall disinfection reaching 86% and some conditions achieving 100% efficacy. The study proposes using MH microbubble dressings for S. aureus elimination, environmental cleaning of affected areas, and shortening dermatitis treatment courses. This approach offers a promising method for enhancing wound care and bacterial control in medical settings.
Rubottom Oxidation Reaction Inspired Divergent Synthesis of α‐Hydroxy Amidines, α‐Bromo Amidines and Tribrominated Indole Derivatives
Authors: Deng Yan‐Qiu , Qin Chang‐Qing , Ren Hai , Chen Guo‐Shu , Ni Chen‐Chen , Liu Yun‐Lin 
Published: February 2025

AbstractA Rubottom‐type oxidation of N‐β‐aminoacrylate substituted indoles with m‐CPBA, providing direct routes to a series of α‐hydroxy amidines was reported. In addition, inspired by this oxidation reaction, a solvent‐controlled switchable bromination of N‐β‐aminoacrylate substituted indoles selectively leading to either 3,3‐dibromo‐oxindole based α‐bromo amidines or tribromo‐substituted indole derivatives was also developed.
The Role of Copper Ions in Mediating the Anti‐Cancer Effects Using Nanomaterials
Authors: Mehmud Irfan , Wu Song , Zhang Shaohua 
Published: February 2025

AbstractCopper plays a pivotal role in human physiology, particularly in oncology, acting both as a facilitator of progression and also as a potential avenue for advanced therapeutic approaches. Maintaining copper homeostasis is crucial. The dysregulation of copper homeostasis is implicated in tumor growth through its involvement in critical processes of angiogenesis, proliferation, and metastasis. The elevation in copper level in the tumor microenvironment (TME) activates oncogenic pathways to drive the neovascularization and sustained growth of malignancies. However, the same reliance on copper offers a unique weakness that can be leveraged for innovative therapeutic interventions. The recent advances in nanomedicine enable the synthesis of nanostructures that can help modulate the level of copper with precision offering multifaceted approaches for copper‐based cancer therapy with controlled release mechanism, optimized structures to induce cuproptosis, selective eradication of cancer cells with minimum and systemic toxicity. This review explores the dual role of copper in cancer biology, emphasizing its contribution to the progression of tumors and its emerging application in targeted cancer therapy. The review also highlights the potential of nanostructures in harnessing copper‐based therapies and their transformative potential from bench to bed side with novel, highly effective, and clinical safety.
Chromosome Missegregation Triggers Tumor Cell Pyroptosis and Enhances Anti‐Tumor Immunotherapy in Colorectal Cancer
Authors: Duan Wei , Hosea Rendy , Wang Lingxian , Ruan Cao , Zhao Fuqiang , Liu Jingyi , Zhao Hezhao , Miyagishi Makoto , Wu Shourong , Kasim Vivi 
Published: February 2025

AbstractImmune checkpoint inhibitor (ICI) therapy is a promising anti‐tumor therapeutic strategy; however, its efficacy in solid tumors is limited. Chromosome missegregation is common in various solid tumors; however, its role in tumor progression remains poorly understood, and its correlation with ICI is yet to be explored. Here, it is found that increased chromosome missegregation promotes tumor immune microenvironment, and eventually immunotherapeutic efficacy, by triggering pyroptosis. yin yang 2 (YY2) is identified as a mitotic checkpoint regulator, which promotes chromosome missegregation by upregulating BUB1B transcription. Increased chromosome missegregation promoted the formation of micronuclei and release of double‐stranded DNA (dsDNA) into the cytosol, triggering an AIM2‐mediated cytosolic dsDNA response. The subsequent pyroptosis strengthened the tumor immune microenvironment, thereby enhancing immunoinfiltration and cytotoxicity of CD8+ T cells, while preventing their exhaustion. Finally, through in vitro and in vivo experiments, it is demonstrated that combining YY2 overexpression‐induced chromosome missegregation/cytosolic dsDNA response and PD‐1 inhibitor significantly enhanced the efficacy of ICI immunotherapy in microsatellite instable and microsatellite stable colorectal cancer cells. Together, these findings provide new insights on the role of chromosome missegregation in triggering cytosolic dsDNA response‐mediated pyroptosis and modulating the tumor immune microenvironment, suggesting a novel strategy for improving ICI therapeutic efficacy in colorectal cancer.
Dislocation‐Driven Formation of Oriented Macroperiodic Metastructures of Curved Single Crystal Lattices in Glass
Authors: Musterman Evan J. , Dierolf Volkmar , Jain Himanshu 
Published: February 2025

AbstractSingle crystals fabricated in glass by localized heating can develop uniquely deformed lattices stabilized by the surrounding amorphous medium. The development of lattice curvature appears to be intrinsic to the crystal growth process in some systems, while the result of the locally changing crystallography in others. In this work, a model laser‐fabricated rotating lattice Sb2S3 crystal grown in stoichiometric glass is used to demonstrate fabrication of novel macroperiodic metastructures that utilize intrinsic lattice curvature superimposed with subtle crystallographic influences. The limited availability of slip systems drives the lattice curvature magnitude to vary with crystal growth direction, maximizing for lattices aligned with the predominant Burgers vector along with corresponding increases in dislocation density. Misaligned lattice orientations form smaller secondary lattice curvatures arising from misaligned Burgers vectors with further elastic contributions. Over extended crystal growth, these secondary components align the lattice to rotate about either the <001> or <010> crystal axes forming repeating metastructures of lattice orientation with periodicity 20–160 microns in length. The mechanistic approach used in this work may be expanded to other systems with known slip systems to better understand and design macroperiodic metastructures.
Structural Colors Go Active
Authors: Li Xinting , Zhao Jiancun , Yang Junyi , Huo Yihui , Yu Yiting 
Published: February 2025

AbstractStructural colors find wide applications for color printing, intelligent display, filtering imaging, etc., owing to their benefits, including high resolution, stable properties, and dynamic tunability. This review first illustrates the mechanisms of structural color generation, such as surface plasmon resonances, localized surface plasmon resonances, Fabry‐Perot resonances, Mie resonances, etc. It then proposes the recent technological strategies employed to realize dynamic structural colors. The integration of structural colors with functional materials like phase‐change, along with the development of color dynamic control mechanisms such as microfluidic chips, micro‐electro‐mechanical system drivers, and microheaters, represents key approaches for spectrum regulation. Furthermore, the review assesses the performance, advantages, and limitations of various technologies for dynamic structural colors. Finally, this review concluded with a section on the future challenges and prospects in large‐area fabrication, practical applications, and performance improvement. It explains the current typical applications, including smart windows, adaptive camouflage, sensors, etc., and explores the processing methods that can achieve large‐area, high‐fidelity preparation of structural colors, such as nanoimprint, deep ultraviolet lithography, immersion lithography, laser printing, etc. This field promises advancements in high‐density data storage, information encryption, and broader market applications.
A Neural Device Inspired by Neuronal Oscillatory Activity with Intrinsic Perception and Decision‐Making
Authors: Gu Congtian , Ma Guoliang , Zhang Mengze , Shen Hu , Pu Liaoyuan , Song Yanhe , Yan Shilong , Wang Dakai , Ba Kaixian , Yu Bin , Han Zhiwu , Ren Luquan 
Published: February 2025

AbstractBionic neural devices often feature complex structures with multiple interfaces, requiring extensive post‐processing. In this paper, a neural device with intrinsic perception and decision‐making (NDIPD), inspired by neuronal oscillatory activity is introduced. The device utilizes alternating signals generated by coupling the human body with the power‐frequency electromagnetic field as both a signal source and energy source, mimicking neuronal oscillatory activity. The peaks and valleys of the alternating signal are differentially modulated to replicate the baseline shift process in neuronal oscillatory activity. By comparing the amplitude of the peaks and valleys in the NDIPD's electrical output signal, the device achieves intrinsic perception and decision‐making regarding the location of mechanical stimulation. This is accomplished using a single interface, which reduces data transmission, simplifies functionality, and eliminates the need for an external power supply. The NDIPD demonstrates a low‐pressure detection limit (<0.02 N), fast response time (<20 ms), and exceptional stability (>200 000 cycles). It shows great potential for applications such as game control, UAV navigation, and virtual vehicle driving. The innovative energy supply method and sensing mechanism are expected to open new avenues in the development of bionic neural devices.
Green impacts of transforming green electricity into microwave for ammonia and urea production
Authors: Jiang Peng , Wang Chenhan , Li Lin , Ji Tuo , Mu Liwen , Lu Xiaohua , Zhu Jiahua 
Published: February 2025

AbstractGreen NH3 production is challenged by high energy consumption, costs, and low yields. Here, we proposed a new green NH3 process utilizing microwave (MW)‐driven N2 transformations (GreenE+MW). This process integrates water electrolysis, air separation, MW‐assisted NH3 synthesis, and NH3 separation. For comparison, a green NH3 process using the Haber–Bosch technology (GreenE+HB) was established, and the energy, economic, and environmental impacts were evaluated. The GreenE+MW process increased NH3 yield by 25.14% and reduced energy consumption by 20.69% compared to the GreenE+HB process. Furthermore, it demonstrated notable advantages in cost and carbon footprint, with green NH3 production costs potentially reduced to 326.84 USD/tNH3 at electricity price of 0.02 USD/kWh. Based on which, a green urea process was proposed, achieving an 85% reduction in carbon emissions (0.128 kgCO2e/kgUrea) compared to conventional methods. This work offers a unique electrification technology to reconstruct the industrial NH3 and urea production processes with a lower carbon footprint.
Investigation of hydrogen spillover in atomically dispersed metal on WO3 for selective hydrogenation
Authors: Sun Yu , Gan Jie , Du Bing , Wang You , Yin Jieyi , Zhang Sai 
Published: February 2025

AbstractOptimizing kinetic barriers of hydrogen spillover for selective hydrogenation on supported catalysts with dual‐active sites faces a significant challenge due to inherent contradiction between H2 activation and *H transformation from metal to support. Herein, the adsorption energy of *H (Ead(H)) on metal has been demonstrated as a viable descriptor for understanding hydrogenation on the WO3 surface with dual‐active sites of single‐atom metals and oxygen vacancies. Theoretical simulations rationalize the optimized value of Ead(H) of −2.49 eV for these dual‐active sites. Furthermore, the absolute value (|ΔEad(H)|) between Ead(H) and −2.49 eV was calculated to directly explore the catalytic activity of M1/NR‐WO3. Among them, the Pt1/NR‐WO3 catalysts with the lowest |ΔEad(H)| exhibited the weakened *H adsorption and enabled efficient H2 activation, resulting in a TOF value of 170,480 h−1 and >99.9% selectivity for the hydrogenation of p‐chloronitrobenzene to p‐chloroaniline. These findings provide new insights into the hydrogen spillover‐promoted selective hydrogenation.
Intrapersonal psychological empowerment: Assessing measurement invariance of the Brief Sociopolitical Control Scale for youth between LGBQ+ and non‐LGBQ+ youth of color
Authors: Lardier David T. , Davis Alexandra N. , Verdezoto Carolina S. , Magliulo Sabrina , Bell Lindsey M. , Herrera Andriana , Garcia‐Reid Pauline , Reid Robert J. 
Published: February 2025

AbstractLesbian, Gay, Bisexual, Queer, and Questioning+ (LGBQ+) Black, Indigenous, and Persons of Color (BIPOC) youth experience significant stigmatization and injustice compared to their non‐LGBQ+ BIPOC peers. Empowerment, civic engagement, and social connection are protective factors that reduce negative psychological outcomes for these youth. Despite this, validated measures to assess empowerment among LGBQ+ BIPOC youth are scarce. This study evaluated the applicability of the newly revised Brief Sociopolitical Control Scale for Youth (BSPCS‐Y) through multigroup confirmatory factor analysis (MGCFA) to examine configural, metric, and scalar invariances between LGBQ+ and non‐LGBQ+ BIPOC youth (N = 1789). Convergent validity was assessed with psychological sense of community and symptoms of depression and anxiety. Results indicated a good model fit for the abbreviated BSPCS‐Y, with no significant group differences in metric and scalar invariances. Subscales for leadership competence and policy control were positively associated with psychological sense of community and negatively associated with depression and anxiety symptoms, with stronger effects of psychological sense of community observed in non‐LGBQ+ BIPOC youth and more robust associations with reduced depression and anxiety among LGBQ+ BIPOC youth. These findings support the BSPCS‐Y as a valid tool for measuring empowerment in diverse BIPOC youth populations.
Biology and Management of Acute Myeloid Leukemia With Mutated NPM1
Authors: Chen Evan C. , Shimony Shai , Luskin Marlise R. , Stone Richard M. 
Published: February 2025

ABSTRACTMutations in nucleophosmin 1 (NPM1) are diseased‐defining genetic alterations encountered in approximately one‐third of cases of acute myeloid leukemia (AML). A mutation in NPM1 confers a more favorable prognosis; however, clinical outcomes of NPM1–mutated AML (NPM1mut AML) are diverse due to the heterogeneity of disease biology, patient characteristics, and treatment received. Research over the last two decades has dramatically expanded our understanding of the biology of NPM1mut AML and led to the development of new therapeutic approaches and strategies for monitoring measurable residual disease (MRD). Here, we review NPM1mut AML with a practical focus on the current treatment landscape, the role of MRD in guiding management, and emerging therapies, including menin inhibitors.
KLK11‐Related Disorder of Cornification Presenting as Inflammatory Skin Disease: A Familial Case Report and Literature Review
Authors: Eiumtrakul Wongsathorn , Wittayakornrerk Sanchawan , Wongkittichote Parith , Nujaroen Saisuda , Pakhathirathien Pattima , Wattanasirichaigoon Duangrurdee 
Published: February 2025

ABSTRACTMendelian disorders of cornification (MeDoC) are a group of heterogeneous inherited skin disorders characterized by hyperkeratosis or scaling. Clinical assessment and skin biopsy are primarily used to differentiate MeDoC from overlapping diseases, including inflammatory skin diseases, and to identify the specific type of MeDoC; however, the results can sometimes be inconclusive. We present two individuals from a family who were initially misdiagnosed with familial pityriasis rubra pilaris, however clinical exome sequencing revealed a likely pathogenic variant in KLK11, a gene recently identified to be associated with MeDoC. This study emphasizes the importance of genetic testing in dermatologic diagnosis.
Dietary Variation Among Herculaneum's Victims of Mt. Vesuvius via Dental Microwear Texture Analysis
Authors: Schmidt Christopher W. , Remy Ashley , D'Anastasio Ruggero 
Published: February 2025

ABSTRACTThe Roman site of Herculaneum provides an extraordinary opportunity to reconstruct ancient diets in the context of life course theory because everyone died simultaneously due to the eruption of Mount Vesuvius in AD 79. Objectives: The current study addresses three primary hypotheses: (1) Subadult diets changed as children aged, (2) adult diets differed from subadult diets, and (3) male and female diets differed as they age. Materials and Methods: This study includes dental microwear texture data from 58 adults (age 16+) and 23 subadults (age 0–16) recovered by Sarah Bisel from within and near to storage rooms adjacent to Herculaneum's beach. The adults include 27 females and 31 males. Dental microwear texture analysis (DMTA) employed standard procedures: data collection used a white‐light confocal profiler at 100×. The DMTA variables were complexity, anisotropy, textural fill volume, and scale of maximum complexity. Statistical methods used Bayesian versions of analysis of variance and correlation (Bayes factors above 1.5 were considered meaningful and above 3.0 significant) as well as discriminant function analysis and binary logistic regression. Results: No differences emerged among the children. Adult diets were significantly lower than the subadults for anisotropy. Among the adults, age affected the females more, particularly for anisotropy. Discussion: Subadult diets did not vary by age, but they did vary. The lower adult anisotropy indicates each adult ate a greater variety of foods compared to the subadults. As females aged, however, their diets became more restricted compared to the males. Overall, age and sex affected the Herculaneum diet.
An innovative hybrid training method for ultrasound in giant cell arteritis, polymyalgia rheumatica and large vessel vasculitis
Authors: Chew Li‐Ching , Hong Cassandra , Dasgupta Bhaskar 
Published: February 2025

AbstractWe propose a novel hybrid physical and virtual training method, complemented by online learning, as an effective method to teach and acquire ultrasound skills. We aim to illustrate this through our experience with a remote ultrasound training module for giant cell arteritis scanning. The significance of this innovation is the ability to mitigate the challenges faced by ultrasound training during pandemic‐times, including the need for physical distancing, group size limitation and overseas travel restrictions. Furthermore, the hybrid training provides an invaluable access to distant specialist cognitive and procedural expertise when conventional means may not be feasible. Although this form of ultrasound training has limitations, such as diminished face‐to‐face contact, we were able to resume training despite the unfavourable circumstances. By harnessing virtual technology for hands‐on training, we can strive to reduce worldwide training inequalities, particularly in areas requiring highly specialised skills where expertise may not be available locally. Even as the world has moved out of ‘lockdown’, the pandemic has serendipitously provided novel ways of doing things; the lessons learnt here can be utilised for future hybrid training models, especially where hands‐on experience is crucial.
Improving the Methane Oxidation by Self‐Adaptive Optimization of Liquid‐Metal Catalysts
Authors: Zhang Haoran , Wang Yinhe , Liu Xiaokang , Wu Fan , Wang Xiaoqian , Ma Chunrong , Han Xiao , Ran Yihua , Zhang Yan , Zhang Zhiwen , Xu Qiang , Wang Zhandong , Zhang Guozhen , Wang Jing , Cai Jun , Liu Zhi , Zhang Yu , Yao Tao , Jiang Jun , Wu Yuen 
Published: February 2025

AbstractMethane (CH4), a major greenhouse gas and abundant carbon resource, presents significant challenges in catalysis due to its high symmetry and thermodynamic stability, which tend to cause over‐oxidation to CO2. Traditional catalysts require high temperatures and pressures to facilitate CH4 conversion, constrained by their rigid structures which lack the flexibility needed for optimizing complex reaction steps. This study introduces a novel Cu embedded liquid metal catalyst (Cu‐LMC) based on gallium alloys, characterized by dynamic, self‐adaptive structures that provide enhanced catalytic performance and selectivity. Our findings reveal that Cu‐LMC achieves a high methane conversion to methanol yield (5.9 mol⋅gCu−1⋅h−1) with a selectivity of 82 %. The results show that mild surface oxidation significantly boosts the catalytic performance of Cu‐LMC by increasing active copper sites through the formation of a Cu−O−Ga configuration while preserving the catalyst‘s structural flexibility. In situ X‐ray Photoelectron Spectroscopy (XPS) and X‐ray Absorption Fine Structure (XAFS) analyses, along with ab initio Molecular Dynamics (AIMD) simulations, demonstrate that the Cu‐LMC enables self‐adaptive structural adjustments that lower methanol desorption energy and increase the energy barrier for by‐product formation, optimizing the overall methane conversion process. The results underscore the importance of designing catalysts with dynamic and adaptable structures to overcome traditional limitations and improve efficiency in catalytic reactions.
A Metastable Oxygen Redox Cathode for Lithium‐Ion Batteries
Authors: Wang Yanfang , Li Cheng , Li Yingzhi , de Benito Raquel , Williams Jacob , Stratford Joshua M. , Li Zhiqiang , Zeng Chun , Qin Ning , Wang Hongzhi , Cao Yulin , Gardner Dominic , Lima da Silva Wilgner , Tippireddy Sahil , Gan Qingmeng , Zhang Fangchang , Luo Wen , Makepeace Joshua W. , Zhou Ke‐Jin , Zhang Kaili , Zhang Fucai , Allan Phoebe K. , Lu Zhouguang 
Published: February 2025

AbstractSimultaneously harnessing cation and anion redox activities in the cathode is crucial for the development of high energy‐density lithium‐ion batteries. However, achieving long‐term stability for both mechanisms remains a significant challenge due to pronounced anisotropic volume changes at low lithium content, unfavorable cation migration, and oxygen loss. Here, we demonstrate exceptionally stable cation and anion redox behavior in a metastable, cobalt‐free layered oxide, Li0.693[Li0.153Ni0.190Mn0.657]O2 (LLNMO). After 50 cycles at 50 mA/g (~0.2 C), the cathode retains 97.4 % of its initial capacity (222.4 mAh/g) with negligible voltage decay. This remarkable stability is attributed to its metastable O6‐type structure (R‐3m symmetry) with unique local geometry. The face‐sharing connectivity between lithium layers and alternating transition metal (TM) layers effectively suppresses TM migration‐induced voltage decay during anion redox. Additionally, the structure balances interlayer cation/cation and anion/anion repulsions, resulting in minimal expansion and contraction during de‐/lithiation (<2.3 % along the c‐axis) and excellent structural reversibility. These findings highlight that layered oxides with a metastable framework are promising cathode candidates for next‐generation ultra‐high‐energy lithium‐ion batteries.