bluuebunny/crossref_metadata_2025_split huggingface dataset:
Relación entre hipoacusia súbita y (COVID-19): revisión sistemática
Authors: Fonseca Arrieta Mary Clara 
Published: December 2023

La hipoacusia súbita es definida como la pérdida repentina de la audición, regularmente es unilateral, pero también tiene una presentación bilateral, siendo menos común pero no imposible (Organización Mundial de la Salud, 2023). Sobre la fisiopatología de la hipoacusia súbita, aún no se ha establecido una causa exacta, sin embargo, hay teorías que sustentan posibles orígenes de la patología. Frente a la emergencia de SARS-Cov19, surgieron diversos síntomas diferenciadores para el diagnóstico de (COVID-19), y aunque ya se han establecido algunos, es importante resaltar que aún no se han estudiado a profundidad todas las manifestaciones de esta enfermedad; en ese sentido, la hipoacusia súbita podría estar relacionada con el (COVID-19), motivo por el cual, se realiza una revisión sistemática para establecer si existe una relación estrecha entre (COVID-19) e hipoacusia súbita. Durante la revisión sistemática se seleccionaron 15 artículos bajo el método PRISMA, que son clasificados en serie de casos, reportes de caso y estudio de cohorte, los cuales fueron analizados de manera detallada con el fin de encontrar la relación entre hipoacusia súbita y (COVID-19); posteriormente se determinó el nivel de evidencia según la tabla de Sackeet. De acuerdo con los resultados es necesario dar continuidad a identificar factores de riesgo con el fin de tener en cuenta medidas preventivas y/o detección temprana para proteger la salud auditiva de las personas afectadas.
Narrative review investigating the nephroprotective mechanisms of sodium glucose cotransporter type 2 inhibitors in diabetic and nondiabetic patients with chronic kidney disease
Authors: Speedtsberg Emma S. , Tepel Martin 
Published: December 2023

Background and aimsOutcome trials using sodium glucose cotransporter type 2 inhibitors have consistently shown their potential to preserve kidney function in diabetic and nondiabetic patients. Several mechanisms have been introduced which may explain the nephroprotective effect of sodium glucose cotransporter type 2 inhibitors beyond lowering blood glucose. This current narrative review has the objective to describe main underlying mechanisms causing a nephroprotective effect and to show similarities as well as differences between proposed mechanisms which can be observed in patients with diabetic and nondiabetic chronic kidney disease.MethodsWe performed a narrative review of the literature on Pubmed and Embase. The research string comprised various combinations of items including “chronic kidney disease”, “sodium glucose cotransporter 2 inhibitor” and “mechanisms”. We searched for original research and review articles published until march, 2022. The databases were searched independently and the agreements by two authors were jointly obtained.ResultsSodium glucose cotransporter type 2 inhibitors show systemic, hemodynamic, and metabolic effects. Systemic effects include reduction of blood pressure without compensatory activation of the sympathetic nervous system. Hemodynamic effects include restoration of tubuloglomerular feedback which may improve pathologic hyperfiltration observed in most cases with chronic kidney disease. Current literature indicates that SGLT2i may not improve cortical oxygenation and may reduce medullar oxygenation.ConclusionSodium glucose cotransporter type 2 inhibitors cause nephroprotective effects by several mechanisms. However, several mediators which are involved in the underlying pathophysiology may be different between diabetic and nondiabetic patients.
Research progress on biochar-based material adsorption and removal of ibuprofen
Authors: Zhan Dan , Ye Aihui , Hou Tingting 
Published: December 2023

Ibuprofen, commonly used for pain relief, inflammation, and to reduce high fever, etc., is a widely available over-the-counter drug. In recent years, due to the excessive use of ibuprofen, its presence in the aquatic environments has shown a significant increasing trend, raising concerns about potential risks to environmental safety, which attracted people’s close attention. Notably, biochar, known as an environmentally friendly functional material, had been widely studied and applied for the removal of ibuprofen in water environments. According to current reports, the adsorption capacity value of biochar for IBP is between 9.69–309 mg/g, and the adsorption mechanism mainly includes π-π stacking, hydrogen bonding, pore filling, etc. In response to this research hotspot, this study reviewed the most recent research progress on the adsorption of ibuprofen using biochar-based materials, including the modified preparation process of biochar and the adsorption mechanism of IBP on various modified biochar surfaces. Additionally, potential challenges and future development directions for the practical applications of biochar were discussed and proposed.
Nutrient fluxes from recent deposits of fine-grained, organic-rich sediments in a Florida estuary
Authors: Fox Austin L. , Trefry John H. 
Published: December 2023

Nutrient fluxes from fine-grained, organic-rich sediments in estuaries can hasten the onset and progression of eutrophication and harmful algal blooms. Targeted efforts to manage degraded sediments and improve estuarine water quality require a better understanding of physicochemical controls and the relative importance of benthic fluxes. Toward that end, we determined fluxes from organic-rich, high porosity sediments deposited during the past 5-6 decades along 60 km of the Indian River Lagoon, a barrier island lagoon in Florida, USA. Highly bioavailable ammonium and phosphate were the predominant chemical forms of interstitial nitrogen and phosphorus in these highly-reducing sediments. Median fluxes of ammonium and phosphate were 320 µmol m-2 h-1 and 11 µmol m-2 h-1, respectively. Fluxes were 3-10 times greater when sediment temperatures were &gt;28°C and interstitial sulfide concentrations were &gt;1 mM. Temperature-compensated fluxes of ammonium and phosphate were significantly correlated with sediment organic matter content; total organic carbon averaged 5.3 ± 2.4% and the maximum was 12.4% for the sediments studied. Fine-scale physical probing, plus lidar data, showed that these organic-rich sediments covered &lt;10% of our study area; however, fluxes from these sediments were estimated to supply 20-40% of internal + external annual loads of nitrogen and phosphorus. Furthermore, 60% of nitrogen and phosphorus fluxes from sediments in the northern Indian River Lagoon came from just 22% of the total surface area. Lagoon segments with high benthic fluxes overlapped in part with areas prone to harmful algal blooms. Effective strategies to manage degraded sediments in the Indian River Lagoon depend on knowing the relative magnitude of internal loading of nutrients as well as appropriate techniques to mitigate sediment fluxes.
Potentially inappropriate drug use in myasthenia gravis: a real-world population-based cohort study in Italy
Authors: Crescioli Giada , Finocchietti Marco , Paoletti Olga , Brunori Paola , Sciancalepore Francesco , Tuccori Marco , Addis Antonio , Vannacci Alfredo , Lombardi Niccolò , Kirchmayer Ursula ,   The CAESAR study group
Published: December 2023

IntroductionTo evaluate the use of pyridostigmine in presence of contraindications, and the use of concomitant potentially contraindicated drugs in a cohort of patients affected by Myasthenia Gravis (MG) in the Italian Regions of Lazio, Tuscany, and Umbria.MethodsThis is a retrospective cohort study. A multivariate logistic regression model was used to evaluate the determinants of pyridostigmine and of potentially contraindicated drugs use in MG patients.ResultsAmong 591 incident pyridostigmine users affected by MG, 91 (15.4%) had at least one of the contraindications considered at the first prescription of pyridostigmine. Patients prescribed with pyridostigmine in presence of contraindications were more frequently affected by diabetes, obesity, and renal diseases. Age 75+ years (odds ratio, OR 4.94, 95% confidence interval, CI 1.60–15.22 for Latium; OR 3.78, 95%CI: 1.26–11.34 for Tuscany; OR 5.83, 95%CI 1.19–28.52 for Umbria), the presence of at least one specific comorbidity (OR 3.93; 95%CI 1.68–9.17 for Latium), and polytherapy (6+ drugs, OR 4.90, 95%CI: 1.35–17.85 for Tuscany) were found to be significantly associated with pyridostigmine use in presence of contraindications. Among patients affected by MG, 1,483 (62.6%) were treated with potentially contraindicated drugs in the first year of follow-up (67.06.9% in Latium; 59% in Tuscany; 57.6% in Umbria). Patients aged 75+ years, those with at least one specific complication or comorbidity, and those exposed to polytherapy were more likely to be treated with a potential contraindicated drug.ConclusionAmong incident users of pyridostigmine, more than 15% of patients have at least one of the contraindications considered, and among patients diagnosed with MG, in the first year of follow-up &gt;60% of subjects were treated with potentially contraindicated drugs.
Nusinersen demonstrates effectiveness in treating spinal muscular atrophy: findings from a three-year nationwide study in Korea
Authors: Cho Jaeso , Lee Jiwon , Kim Jihye , Lee Hyunjoo , Kim Min-Jee , Lee Yun Jeong , Yum Mi-Sun , Byun Ji-Hye , Lee Chong Guk , Lee Young-Mock , Lee Jeehun , Chae Jong-Hee 
Published: December 2023

IntroductionNusinersen is the first drug approved for spinal muscular atrophy (SMA) treatment. In this study, we aimed to evaluate the long-term safety and efficacy of nusinersen, assess the therapeutic effects based on the treatment initiation timing and baseline motor function, and explore the perception of functional improvement from either parents or patients, utilizing 3-year nationwide follow-up data in South Korea.MethodsWe enrolled patients with SMA who were treated with nusinersen under the National Health Insurance coverage, with complete motor score records available and a minimum treatment duration of 6 months. To evaluate the motor function of patients, the Hammersmith Infant Neurological Examination-2 (HINE-2) was used for type 1 and the Expanded Hammersmith Functional Motor Scale (HFMSE) was used for types 2 and 3 patients. A significant improvement was defined as a HINE-2 score gain ≥5 for patients with type 1 and an HFMSE score ≥ 3 for patients with types 2 and 3 SMA. Effects of treatment timing were assessed. Patients with type 2 were further categorized based on baseline motor scores for outcome analysis. We also analyzed a second dataset from five tertiary hospitals with the information on parents/patients-reported impressions of improvement.ResultsThe study comprised 137 patients, with 21, 103, and 13 patients representing type 1, 2, and 3 SMA, respectively. At the 3-year follow-up, the analysis encompassed 7 patients with type 1, 12 patients with type 2, and none with type 3. Nearly half of all enrolled patients across SMA types (42.8, 59.2 and 46.2%, respectively) reached the 2-year follow-up for analysis. Patients with type 1 SMA exhibited gradual motor function improvement over 1-, 2-, and 3-year follow-ups (16, 9, and 7 patients, respectively). Patients with type 2 SMA demonstrated improvement over 1-, 2-, and 3-year follow-ups (96, 61 and 12 patients, respectively). Early treatment from symptom onset resulted in better outcomes for patients with type 1 and 2 SMA. In the second dataset, 90.7% of 108 patients reported subjective improvement at the 1-year follow-up.ConclusionNusinersen treatment for types 1–3 SMA is safe and effective in long-term follow-up. Early treatment initiation was a significant factor affecting long-term motor outcome.
Effect of intracranial electrical stimulation on dynamic functional connectivity in medically refractory epilepsy
Authors: Lu Meili , Guo Zhaohua , Gao Zicheng 
Published: December 2023

ObjectiveThe objective of this study was to explore the distributed network effects of intracranial electrical stimulation in patients with medically refractory epilepsy using dynamic functional connectivity (dFC) and graph indicators.MethodsThe time-varying connectivity patterns of dFC (state-based metrics) as well as topological properties of static functional connectivity (sFC) and dFC (graph indicators) were assessed before and after the intracranial electrical stimulation. The sliding window method andk-means clustering were used for the analysis of dFC states, which were characterized by connectivity strength, occupancy rate, dwell time, and transition. Graph indicators for sFC and dFC were obtained using group statistical tests.ResultsDFCs were clustered into two connectivity configurations: a strongly connected state (state 1) and a sparsely connected state (state 2). After electrical stimulation, the dwell time and occupancy rate of state 1 decreased, while that of state 2 increased. Connectivity strengths of both state 1 and state 2 decreased. For graph indicators, the clustering coefficient, k-core, global efficiency, and local efficiency of patients showed a significant decrease, but the brain networks of patients exhibited higher modularity after electrical stimulation. Especially, for state 1, there was a significant decrease in functional connectivity strength after stimulation within and between the frontal lobe and temporary lobe, both of which are associated with the seizure onset.ConclusionOur findings demonstrated that intracranial electrical stimulation significantly changed the time-varying connectivity patterns and graph indicators of the brain in patients with medically refractory epilepsy. Specifically, the electrical stimulation decreased functional connectivity strength in both local-level and global-level networks. This might provide a mechanism of understanding for the distributed network effects of intracranial electrical stimulation and extend the knowledge of the pathophysiological network of medically refractory epilepsy.
Validation of a debiasing addition to Analytical Hieratical Process tools to increase the effects of side-stream utilization and the choice of the filtration system in the European mussel aquaculture and processing industry
Authors: Schrøder Søren Espersen , San Martin David , Foti Giuseppe , Gutierrez Monica , Iñarra Chastagnol Bruno , Nielsen J. Rasmus , Larsen Erling 
Published: December 2023

Introduction: New EU regulations for increased sustainability and better utilization of side-streams are pushing the European mussel farming and processing industry to adapt to new regulations regarding their wastewater production, which leads to incentives for optimizing methods for better utilization of this side-stream resource. In this study, one such European company is faced with a choice of a filtration system out of three possible options, to invest in and achieve the option with the best balance between economic gain and environmentally sound production.Method: For this, a specialized Analytical Hieratical Processes (AHP) tool was utilized together with a supplementary Debias Your Decisions (DYD) tool to visualize the local best choice for the company.Results: Based on the generated user weights from the company it was apparent that the user weights were biased towards certain criteria in the AHP tool, which meant that half of the tool’s criteria had greatly diminished influence on the tool’s scores. This brought into question the objectivity of the Performance index (Pi) score results from the AHP tool when the user weights were applied, since these Pi scores deviated significantly from the expert Pi scores. The supplement tool DYD was found to be able to identify the dominant decision biases influencing the user weights in the current case, which enabled the implementation of relevant debiasing techniques to correct for the overweighted user weights from the company. With these corrections and the case company’s input data, the optimum alternative suggested for the case company is membrane filtration based on the final Pi scores for all weight sets.Discussion: This process and final debiased results further validated the AHP tools results as objectively grounded due to their convergence with the experts’ scoring results. This study also served as further validation for the new supplement DYD tool as the current sensitivity analysis showed the tool’s robustness to be high.
Stability Analysis of Finite Time for a Class of Nonlinear Time-Delay Fractional-Order Systems
Authors: Ben Makhlouf Abdellatif , Mchiri Lassaad , Rhaima Mohamed 
Published: December 2023

In this study, we delve into the examination of Finite Time Stability (FTS) within a specific class of Fractional-Order Systems (FOS) with time delays. By applying a fixed-point theorem, we establish novel sufficient conditions to ensure FTS for time-delayed FOS within 1<σ<2. Moreover, we investigate the existence and uniqueness of global solutions for this particular system. To demonstrate the credibility of our results, we substantiate our findings through the presentation of two illustrative examples.
On the Verge between Retranslation and Revision: Revisiting Translations of Modernist Novels in Türkiye
Authors: İrem Ceren Doğan 
Published: December 2023

This research aims to elucidate the underlying forces that propelled the first translators to reprocess their texts within the framework of modernist literature, and to reveal the nature of these reprocessed texts as retranslations or revisions. The corpus of this study is composed of modernist novels To The Lighthouse (1927), Lolita (1955), Heart of Darkness (1899), and Nightwood (1936). The first translators of these novels into Turkish felt the need to reprocess texts over long periods. The second versions could be classified as retranslations according to the characteristics outlined by the retranslation hypothesis. However, considering the limitations of this hypothesis, particularly regarding retranslations from the 2000s onward, it seems insufficient to explain current dynamics. To establish a clear differentiation between revision and retranslation, it is essential to conduct a comprehensive comparative analysis of the first and subsequent versions. Based on the analysis, it has been determined that there are limited but significant changes in the revised texts. While the number of alterations may not reach statistical significance to label them as "retranslations", they can be categorized as "revisions." It has been concluded that the triggering factors behind the revisions are related to the changing sociocultural factors, patronage and the habitus of the translators.
ANALISIS KEHILANGAN PRODUKSI KERNEL PADA LIGHT TENERA DRY SEPARATOR (LTDS) II PT. ABCDE
Authors: Ilmannafian Adzani Ghani , Herliyana Herliyana 
Published: December 2023

Pabrik pengolahan kelapa sawit (PKS) Koperasi Sawit Makmur PT ABCDE terletak di Desa Tajau Mulya, Kecamatan Batu Ampar, Kabupaten Tanah Laut. Proses pengolahan kelapa sawit terdiri dari beberapa stasiun antara lain Stasiun penerimaan, stasiun perebusan, stasiun penebah, stasiun press, stasiun klarifikasi, stasiun nut dan kernel. Pemisahakan kernel dengan cangkang yang telah di pecah dilakukan dengan pemisahan kering dan pemisahan basah.Pemisahan kering dilakukan dengan Light Tenera Dry Separator (LTDS). LTDS merupakan alat yang berfungsi untuk memisahkan antara kernel,nut, dan fiber yang masih terikut selama proses pengelolahan.Dari pengamatan yang dilakukan terdapat losses pada inti/kernel yang ada pada LTDS II kehilangan kernel selama bulan Oktober-Desember 2022 melebihi target yaitu diatas 2,5% dan losses tertinggi pada bulan Desember dengan rata- rata kernel losses 3,02, hal ini disebabkan karena faktor bahan baku, manusia dan mesin.
Pemberdayaan Perempuan Masyarakat Tolaki Berbasis Home Industri melalui Kerajinan Kain Perca sebagai Upaya Peningkatan Ekonomi Keluarga
Authors: Ipandang Ipandang 
Published: December 2023

Pemberdayaan didenfinisikan sebagai proses dimana pihak yang tidak berdaya bisa mendapatkan kontrol yang lebih banyak terhadap kondisi atau keadaan dalam kehidupanya. Kontrol ini meliputi kontrol terhadap berbagai macam sumber (mencakup fisik dan intelektual) dan ideologi meliputi (keyakinan, nilai dan pemikiran).Metode yang digunakan yaitu 1] metode pendampingan 2] langkah langkah tahapan pendampingan, hasil yang diharapkan 1] bisa bedampak pada masyarakat 2] bisa berdampak pada keilmuan,pembahasanya 1] isu dan fokus pemberdayaan, 2] tujuan, 3] alasan memilih dampingan, 4] kondisi subjek dampingan, 5] output pendampingan yang diharapkan, diseminasinya yaitu 1] mitra SDM, 2] supplier, 3] lokasi, 4] eksperimen, 5] spesifikasi produk, 6] segmentasi pasar. Pemberdayaan perempuan menjadi strategi penting dalam meningkatkan peran dan potensi diri agar lebih mampu untuk mandiri dan berkarya. Dengan adanya pemberdayaan wanita berbasis home industri dalam mengkreasikan kain perca, diharapkan mampu meningkatkan taraf perekonomian masyarakat dari yang awalnya lemah menjadi satu atau dua tingkat lebih tinggi dari level sebelumnya, sekaligus menekan angka / prosentase terbuangnya waktu untuk hal yang kurang positif dan tidak berdaya guna (ngerumpi) menjadi waktu yang produktif, kreatif dan inovatif.
Empowerment is defined as a process whereby parties who are powerless can gain more control over the conditions or circumstances in their lives. This control includes control over a variety of sources (including physical and intellectual) and ideology includes (beliefs, values ​​and thoughts). The method used is 1) mentoring method 2) step by step stages of mentoring, expected results 1) can have an impact on society 2 ] can have an impact on science, the discussion is 1] issues and focus on empowerment, 2] objectives, 3] reasons for choosing assistance, 4] conditions for assisted subjects, 5] expected output of assistance, dissemination, namely 1] HR partners, 2] suppliers, 3] location, 4] experiment, 5] product specification, 6] market segmentation. Empowering women is an important strategy in increasing the role and potential of themselves so that they are more able to be independent and work. With the empowerment of women based on the home industry in creating patchwork, it is expected to be able to increase the economic level of the community from initially weak to one or two levels higher than the previous level, as well as to reduce the number / percentage of time wasted on things that are less positive and useless (huddling) is a productive, creative and innovative time.
The Attitude of the German Humanists of the XVI Century
to the Catholic Church
Authors: Filatova Sofia 
Published: December 2023

The article examines the works of German humanists of the XVI century. The author studies the attitude of the German humanists of the XVI century to the Catholic Church. The analysis of the historical context and characteristic features of German humanistic thought in the XVI century is made, as well as the positions of the leaders of the humanistic and reformation movement in relation to the Catholic Church are considered. The article emphasizes that German humanists showed a critical attitude towards the church, condemning its theological errors and shortcomings in practice. At the same time, the author points out, that humanists did not deny the importance of the church and its role in society, but tried to achieve its reformation and improvement. The article shows that humanists treated the Catholic Church ambiguously, their views on its role and significance in society were peculiar. German humanists
in the XVI century were critical of the Catholic Church, but did not reject its teachings as a whole. They sought to identify and rid the church of vicious practices. Overall, the article is of interest to anyone studying the history of the church and humanistic thought in the XVI century.