bluuebunny/crossref_metadata_2025_split huggingface dataset:
Exploring Non‐Toxic Lower Dimensional Perovskites for Next‐Generation X‐Ray Detectors
Authors: Ali Nasir , Shehzad Khurram , Attique Sanam , Ali Ayaz , Akram Fazli , Younis Adnan , Ali Shahid , Sun Yan , Yu Guolin , Wu Huizhen , Dai Ning 
Published: January 2024

AbstractOwing to their extraordinary photophysical properties, organometal halide perovskites are emerging as a new material class for X‐ray detection. However, the existence of toxic lead makes their commercialization questionable and should readily be replaced. Accordingly, several lead alternatives have been introduced into the framework of conventional perovskites, resulting in various new perovskite dimensionalities. Among these, Pb‐free lower dimensional perovskites (LPVKs) not only show promising X‐ray detecting properties due to their higher ionic migration energy, wider and tunable energy bandgap, smaller dark currents, and structural versatility but also exhibit extended environmental stability. Herein, first, the structural organization of the PVKs (including LPVKs) is summarized. In the context of X‐ray detectors (XDs), the outstanding properties of the LPVKs and active layer synthesis routes are elaborated afterward. Subsequently, their applications in direct XDs are extensively discussed and the device performance, in terms of the synthesis method, device architecture, active layer size, figure of merits, and device stability are tabulated. Finally, the review is concluded with an in‐depth outlook, thoroughly exploring the present challenges to LPVKs XDs, proposing innovative solutions, and future directions. This review provides valuable insights into optimizing non‐toxic Pb‐free perovskite XDs, paving the way for future advancements in the field.
Sustainable Photocatalytic Acylation of Transition Metal Dichalcogenides with Atom Economy
Authors: Sideri Ioanna K. , Canton‐Vitoria Ruben , Ojeda‐Galvan Hiram J. , Quintana Mildred , Tagmatarchis Nikos 
Published: January 2024

AbstractTransition metal dichalcogenides (TMDs) are promising 2D nanomaterials for diverse applications, but their intrinsic chemical inertness hinders their modification. Herein, a novel approach is presented for the photocatalytic acylation of 2H‐MoS2 and 2H‐MoSe2, utilizing tetrabutyl ammonium decatungstate ((nBu4N)4W10O32) polyoxometalate complex as a catalyst and a conventional halogen lamp as a source of irradiation. By harnessing the semiconducting properties of TMDs, new avenues emerge for the functionalization of these materials. This novel photocatalytic protocol constitutes the first report on the chemical modification of 2D nanomaterials based on a catalytic protocol and applies to both aliphatic and aromatic substrates. The scope of the decatungstate‐photocatalyzed acylation reaction of TMDs is explored by employing an alkyl and an aromatic aldehyde and the success of the methodology is confirmed by diverse spectroscopic, thermal, microscopy imaging, and redox techniques. This catalytic approach on modifying 2D nanomaterials introduces the principles of atom economy in a functionalization protocol for TMDs. It marks a transformative shift toward more sustainable and efficient methodologies in the realm of TMD modification and nanomaterial chemistry.
Light‐driven reversible and repeatable switching between ultrastable and unstable liquid foam
Authors: Yu Xiaoyang , Li Huan , Qiu Ke , Kang Ning , Xu Zhoumei , Li Qian , Lu Shouxiang 
Published: January 2024

AbstractLiquid foams with tunable and photoresponsive stabilities and mechanical properties are highly desired in many domains, including the chemical and environmental protection industries. Here, we constructed photoresponsive liquid foams by structuring the interfacial adsorption layers and nanoparticle‐embedded Plateau borders of the foam with biodegradable components. These foams exhibited ultrahigh foam stability but were easily destroyed by light, leading to a clean recovery of the liquid phase. In the absence of light, the hydroxypropyl cellulose (HPC) coils in the foam formed mechanically strong liquid films or “cohesive states.” Under irradiation, the ultrathin black phosphorus nanosheets induced changes in the packing parameters of the HPC assemblies within the Plateau borders and led to coil‐to‐globule transitions of the HPC and formed unstable liquid films with a “mobile state.” The two interfacial states were reversibly and repeatedly switched by turning the light on and off, which caused rapid bubble coalescence and foam collapse, and we also proved that this destabilizing mechanism was inhibited by cellulose nanocrystals. This work provides an environmentally friendly approach to controlling foam stability, and the proposed strategy can be expanded to the production of multiresponsive fully liquid objects in theory.
Development of network‐guided transcriptomic risk score for disease prediction
Authors: Cao Xuan , Zhang Liangliang , Lee Kyoungjae 
Published: January 2024

SummaryOmics data, routinely collected in various clinical settings, are of a complex and network‐structured nature. Recent progress in RNA sequencing (RNA‐seq) allows us to explore whole‐genome gene expression profiles and to develop predictive model for disease risk. In this study, we propose a novel Bayesian approach to construct RNA‐seq‐based risk score leveraging gene expression network for disease risk prediction. Specifically, we consider a hierarchical model with spike and slab priors over regression coefficients as well as entries in the inverse covariance matrix for covariates to simultaneously perform variable selection and network estimation in high‐dimensional logistic regression. Through theoretical investigation and simulation studies, our method is shown to both enjoy desirable consistency properties and achieve superior empirical performance compared with other state‐of‐the‐art methods. We analyse RNA‐seq gene expression data from 441 asthmatic and 254 non‐asthmatic samples to form a weighted network‐guided risk score and benchmark the proposed method against existing approaches for asthma risk stratification.
Kerbfallkombinationsmodell zur Berücksichtigung von Schweißnahtimperfektionen beim Ermüdungsnachweis
Authors: Bartsch Helen , Feldmann Markus 
Published: January 2024

AbstractFertigungsbedingte Imperfektionen treten in jeder Schweißnaht auf, die insbesondere in ermüdungsbeanspruchten Stahlkonstruktionen, wie z. B. Stahlbrücken, eine große Rolle spielen. Denn diese Schweißnahtimperfektionen beeinflussen die Ermüdungsfestigkeit der Schweißverbindung. Die Verknüpfung der Ermüdungsfestigkeitswerte mit dem Qualitätsniveau der Schweißverbindungen ist jedoch bisher nur unzureichend geschehen. Die Größen tolerierbarer Schweißnahtimperfektionen sind zwar gemäß DIN EN 1090‐2, DIN EN 1993‐1‐9 und DIN EN ISO 5817 vorgegeben, doch sie wurden ohne wissenschaftlichen Hintergrund festgelegt. Die wahren Grenzwerte sind unbekannt. Dies bot den Anlass, eine Methode zu entwickeln, mit der Kerbfälle abhängig von der Größe der Schweißnahtimperfektionen bestimmt werden können. Auf Basis von Ermüdungsversuchen geschweißter Details des Kreuzstoßes und der Quersteife mit Imperfektionen wurden numerische Untersuchungen mithilfe der Finite‐Elemente‐Methode und lokaler Ermüdungskonzepte durchgeführt. Die Ergebnisse dieser Berechnungen liefern einen quantitativen Zusammenhang zwischen Ermüdungsfestigkeit und Größe einzelner Schweißnahtimperfektionen. Zusätzlich wurde das Kerbfallkombinationsmodell entwickelt, mit dem mehrere Imperfektionen auf probabilistische Weise im Kerbfall effizient berücksichtigt werden können. Da bei Anwendung des vorgestellten Verfahrens zeitaufwendige Überarbeitungen von Schweißnähten in Zukunft entfallen können, wird das Nachweiskonzept für ausreichende Sicherheit gegen Ermüdungsversagen hinsichtlich der Kosten‐ und Ressourceneffizienz verbessert.
Pressure stabilization method for the 2D/3D time‐dependent natural convection equations with salt concentration
Authors: Liang Youlei , Liu Demin 
Published: January 2024

AbstractIn this paper, the pressure stabilization method for the 2D/3D time‐dependent natural convection equations with salt concentration (NCSC) is considered. The artificial pressure diffusion term is introduced to reduce the constraint of the incompressible condition. The first‐order backward difference formula is adopted to approximate the temporal derivative terms, the diffusion terms in NCSC are treated implicitly, the convective terms in momentum equation are treated semi‐implicitly, the convective terms in energy equation and salt concentration equation are treated implicitly. The error estimates for the semi‐discrete pressure stabilization method are given. Some numerical experiments are presented to verify the theoretical results and show the reliability of the proposed method.
Psychotic Disorders
Authors: Krüger Reinhard T. 
Published: January 2024

AbstractThe disorder-specific psychodrama therapy of psychoses was the first step toward the development of psychodrama as a psychotherapy method. In the as-if mode of play, the patient directly develops his rudimentary metacognitive processes that produce his dysfunctional delusional thought content with the help of the therapist as a doppelganger. He tries to develop his delusion production into a coping story. In doing this, the patient gains ego control over his delusional production as well as an insight into his illness. This stops the disintegration of his self. Over time, he learns to stop his production of delusional content in a self-determined manner. The method requires the therapist to be willing to give up his own natural defense against the absurdity of delusion and, as a doppelganger, to courageously engage transmodally with the patient’s symptom production. The author has adapted and expanded the methodological approach developed by Moreno to suit the conditions and necessities of the present time. The described disorder-specific psychodramatic action methods complement depth-psychological, behavioral, and systemic psychotherapy approaches to psychoses with a disorder-specific essential quality.
Diagnostic accuracy of doctors at the emergency department and radiologists in differentiating between complicated and uncomplicated acute appendicitis
Authors: Scheijmans Jochem C G , Bom Wouter J , Deniz Rabia S , van Geloven Anna A W , Boermeester Marja A ,   The SAS Collaborative, Alberts F , Bachiriden Bakker S MA , Bisschops B , Boersma E , Bolmers M D M , Bosman W M , Bril H , Buurman C , Courrech Staal E F W , Davids P , Detering R , Dijkgraaf M G W , Dijkstra B L , Drillenburg P , Dinaux A , van Duijvendijk P , van Eden W J , Franken R , Gans S , Gaspersz M , van Geel A M , Gerhards M F , Ghori H , Gratama J W C , Groenendijk I , Hellebrekers P , van Hemert A , Henebiens M , Heydari H , Hof K in ’t , Hoogteijling T J , Huisman P M , van Ingen G , Jensch S , Jonker A M , Joosten F , Koens L , Kraaijvanger N , Kuijpers K C , Le Large T Y S , Linzel D , Loos M H J , Lopes Cardozo A M F , Meijer-Jorna L B , Mulder M , Mullaart N , Oosterling S J , Oudejans J , Pappot T , Peeters S , Pleiter C , de Roos MA , Rosman C , van Rossem C C , Scheurkogel M M , Scholten L , Schut T , Stoker J , Tiddens O W T , Ubels S , de Vries F E E , Walraven L F J , Wiegerinck E M A , Wiggers J K , Witt M , Wolfhagen N , van de Wouw L 
Published: January 2024

Abstract
Purpose
To determine the accuracy of final judgements of doctors at the emergency department (ED) and radiologists to differentiate between complicated and uncomplicated acute appendicitis, because these have different treatment options.

Methods
This prospective, multicenter study included adult patients with imaging-confirmed acute appendicitis, operated with intention to appendectomy. Both doctors at ED and radiologists assessed appendicitis severity as a final judgement of “uncomplicated” or “complicated” appendicitis. Doctors at ED integrated clinical, laboratory, and imaging findings. Radiologists relied solely on imaging findings. Outcomes were accuracy of these judgements for diagnosis of complicated appendicitis compared to the reference standard by an adjudication committee.

Results
After imaging, 1070 patients with confirmed acute appendicitis were included. Doctors at ED accurately labelled 656 of 701 (93.6%) patients with true uncomplicated appendicitis as uncomplicated, and 163 of 369 (44.2%) patients with true complicated appendicitis were labelled as complicated. Sensitivity, specificity, and positive and negative predictive values (PPV and NPV) for complicated appendicitis were 44.2%, 93.6%, and 78.4% and 76.1%, respectively. Comparable accuracy was found for the radiologist’s assessment in 941 patients, with true positive rates of 92.2% (581 of 630 patients) for uncomplicated appendicitis and 46.6% (145 of 311 patients) for complicated appendicitis.

Conclusion
More than half of all patients with true complicated appendicitis is incorrectly classified as uncomplicated appendicitis according to the judgements of doctors at ED, integrating clinical, laboratory, and imaging results, and of radiologists assessing diagnostic imaging. These judgements are thereby not sufficiently reliable in ruling out complicated appendicitis.
Real-time tilting and twisting motions of ligand-bound states of α7 nicotinic acetylcholine receptor
Authors: Yang Yue , Arai Tatsuya , Sasaki Daisuke , Kuramochi Masahiro , Inagaki Hidetoshi , Ohashi Sumiko , Sekiguchi Hiroshi , Mio Kazuhiro , Kubo Tai , Sasaki Yuji C. 
Published: January 2024

AbstractThe α7 nicotinic acetylcholine receptor is a member of the nicotinic acetylcholine receptor family and is composed of five α7 subunits arranged symmetrically around a central pore. It is localized in the central nervous system and immune cells and could be a target for treating Alzheimer’s disease and schizophrenia. Acetylcholine is a ligand that opens the channel, although prolonged application rapidly decreases the response. Ivermectin was reported as one of the positive allosteric modulators, since the binding of Ivermectin to the channel enhances acetylcholine-evoked α7 currents. One research has suggested that tilting motions of the nicotinic acetylcholine receptor are responsible for channel opening and activation. To verify this hypothesis applies to α7 nicotinic acetylcholine receptor, we utilized a diffracted X-ray tracking method to monitor the stable twisting and tilting motion of nAChR α7 without a ligand, with acetylcholine, with Ivermectin, and with both of them. The results show that the α7 nicotinic acetylcholine receptor twists counterclockwise with the channel transiently opening, transitioning to a desensitized state in the presence of acetylcholine and clockwise without the channel opening in the presence of Ivermectin. We propose that the conformational transition of ACh-bound nAChR α7 may be due to the collective twisting of the five α7 subunits, resulting in the compression and movement, either downward or upward, of one or more subunits, thus manifesting tilting motions. These tilting motions possibly represent the transition from the resting state to channel opening and potentially to the desensitized state.
Class VI G protein-coupled receptors in Aspergillus oryzae regulate sclerotia formation through GTPase-activating activity
Authors: Kim Dong Min , Sakamoto Itsuki , Arioka Manabu 
Published: January 2024

Abstract
G protein-coupled receptors (GPCRs) comprise the largest family of transmembrane receptors in eukaryotes that sense and transduce extracellular signals into cells. In Aspergillus oryzae, 16 canonical GPCR genes are identified and classified into nine classes based on the sequence similarity and proposed functions. Class VI GPCRs (AoGprK-1, AoGprK-2, and AoGprR in A. oryzae), unlike other GPCRs, feature a unique hybrid structure containing both the seven transmembrane (7-TM) and regulator of G-protein signaling (RGS) domains, which is not found in animal GPCRs. We report here that the mutants with double or triple deletion of class VI GPCR genes produced significantly increased number of sclerotia compared to the control strain when grown on agar plates. Interestingly, complementation analysis demonstrated that the expression of the RGS domain without the 7-TM domain is sufficient to restore the phenotype. In line with this, among the three Gα subunits in A. oryzae, AoGpaA, AoGpaB, and AoGanA, forced expression of GTPase-deficient mutants of either AoGpaA or AoGpaB caused an increase in the number of sclerotia formed, suggesting that RGS domains of class VI GPCRs are the negative regulators of these two GTPases. Finally, we measured the expression of velvet complex genes and sclerotia formation-related genes and found that the expression of velB was significantly increased in the multiple gene deletion mutants. Taken together, these results demonstrate that class VI GPCRs negatively regulate sclerotia formation through their GTPase-activating activity in the RGS domains.

Key points
• Class VI GPCRs in A. oryzae regulate sclerotia formation in A. oryzae
• RGS function of class VI GPCRs is responsible for regulation of sclerotia formation
• Loss of class VI GPCRs resulted in increased expression of sclerotia-related genes
Allogeneic CAR-T cells with of HLA-A/B and TRAC disruption exhibit promising antitumor capacity against B cell malignancies
Authors: Chen Xinfeng , Tan Binghe , Xing Haizhou , Zhao Xuan , Ping Yu , Zhang Zhen , Huang Jianmin , Shi Xiujuan , Zhang Na , Lin Boxu , Cao Weijie , Li Xin , Zhang Xudong , Li Ling , Jiang Zhongxing , Zhang Mingzhi , Li Wei , Liu Mingyao , Du Bing , Zhang Yi 
Published: January 2024

Abstract
Background
Although chimeric antigen receptor T (CAR-T) cells have been proven to be an effective way of treating B cell malignancies, a lot of patients could not benefit from it because of failure in CAR-T cell manufacturing, disease progression, and unaffordable price. The study aimed to explore universal CAR-T cell products to extend the clinical accessibility.

Methods
The antitumor activity of CRISPR/Cas9-edited allogeneic anti-CD19 CAR-T (CAR-T19) cells was assessed in vitro, in animal models, and in patients with relapsed/refractory (R/R) acute B cell lymphoblastic leukemia (B-ALL) or diffuse large B cell lymphoma.

Results
B2M−/TRAC− universal CAR-T19 (U-CAR-T19) cells exhibited powerful anti-leukemia abilities both in vitro and in animal models, as did primary CD19+ leukemia cells from leukemia patients. However, expansion, antitumor efficacy, or graft-versus-host-disease (GvHD) was not observed in six patients with R/R B cell malignancies after U-CAR-T19 cell infusion. Accordingly, significant activation of natural killer (NK) cells by U-CAR-T19 cells was proven both clinically and in vitro. HLA-A−/B−/TRAC− novel CAR-T19 (nU-CAR-T19) cells were constructed with similar tumoricidal capacity but resistance to NK cells in vitro. Surprisingly, robust expansion of nU-CAR-T19 cells, along with rapid eradication of CD19+ abnormal B cells, was observed in the peripheral blood and bone marrow of another three patients with R/R B-ALL. The patients achieved complete remission with no detectable minimal residual disease 14 days after the infusion of nU-CAR-T19 cells. Two of the three patients had grade 2 cytokine release syndrome, which were managed using an IL-6 receptor blocker. Most importantly, GvHD was not observed in any patient, suggesting the safety of TRAC-disrupted CAR-T cells generated using the CRISPR/Cas9 method for clinical application.

Conclusions
The nU-CAR-T19 cells showed a strong response in R/R B-ALL. nU-CAR-T19 cells have the potential to be a promising new approach for treating R/R B cell malignancies.
Generation and assessment of cytokine-induced killer cells for the treatment of colorectal cancer liver metastases
Authors: Li Celine Man Ying , Tomita Yoko , Dhakal Bimala , Tin Teresa , Li Runhao , Wright Josephine A. , Vrbanac Laura , Woods Susan L. , Drew Paul , Price Timothy , Smith Eric , Maddern Guy J. , Fenix Kevin 
Published: January 2024

AbstractColorectal cancer (CRC) is the second leading cause of cancer-related death worldwide. Cytokine-induced killer (CIK) cells are an adoptive immunotherapy reported to have strong anti-tumour activity across a range of cancers. They are a heterogeneous mix of lymphoid cells generated by culturing human peripheral blood mononuclear cells with cytokines and monoclonal antibodies in vitro. In this study, we investigated the yield and function of CIK cells generated from patients with CRC liver metastases. We first showed that CIK cells generated in serum free medium X-VIVO 15 were comparable to those from RPMI medium with 10% FBS in terms of the number and percentages of the main subsets of cells in the CIK culture, and the intracellular levels of granzyme B and perforin, and the pro-inflammatory cytokines IL-2, IFN-γ and TNF-α. The CIK cells were cytotoxic to CRC cell lines grown in 2D cultures or as spheroids, and against autologous patient-derived tumour organoids. Donor attributes such as age, sex, or prior chemotherapy exposure had no significant impact on CIK cell numbers or function. These results suggest that functional CIK cells can be generated from patients with CRC liver metastatic disease, and support further investigations into the therapeutic application of autologous CIK cells in the management of patients with CRC liver metastases.
Feasibility and effectiveness of communication tools for addressing intimacy and sexuality in patients with cancer: a systematic review
Authors: Arends Susanne A. M. , van Rossum Carlijn E. , Eeltink Corien M. , Robertus Jantien E. , Schoonmade Linda J. , Francke Anneke L. , Jongerden Irene P. 
Published: January 2024

Abstract
Purpose
Patients diagnosed with cancer might experience changes in intimacy and sexuality due to the illness itself, treatment, or psychological and social factors. Healthcare professionals (HCPs) often feel reluctant to discuss these changes. This study aimed to provide an overview of the feasibility and effectiveness of communication tools that support communication regarding changes in intimacy or sexuality among patients with cancer.

Methods
This is a systematic review. Databases are PubMed, Embase, CINAHL, PsycInfo, Web of Science and Cochrane Library from inception to June 2023. The Mixed Methods Appraisal Tool was used to assess included studies. Data were summarized in data charting forms.

Results
In total 35 studies were included, published between 2001 and 2023. Most had a quantitative design and moderate methodological quality. In 11 studies, the PLISSIT model (Permission, Limited Information, Specific Suggestions, Intensive Therapy) was used. Tools were integrated in counselling sessions or training programmes for individual patients, couples, groups of patients, or HCPs. All tools were considered feasible by patients or HCPs. Twenty studies reported significant improvement in sexual functioning, quality of life, quality of care or combined outcomes.

Conclusion
Tools to support communication about changes in intimacy and sexuality among patients with cancer seem feasible and effective. The most commonly used tool, the PLISSIT model, proved to be feasible for HCPs and to have a positive effect on patients’ and partners’ sexual functioning and quality of life. Giving attention to changes in intimacy and sexuality seems to be important in itself, regardless of the communication tool or approach used.