bluuebunny/crossref_metadata_2025_split huggingface dataset:
Rationalizing kinetic behaviors of isolated boron sites catalyzed oxidative dehydrogenation of propane
Authors: Tian Hao , Li Wenying , He Linhai , Zhong Yunzhu , Xu Shutao , Xiao Hai , Xu Bingjun 
Published: October 2023

AbstractBoron-based catalysts exhibit high alkene selectivity in oxidative dehydrogenation of propane (ODHP) but the mechanistic understanding remains incomplete. In this work, we show that the hydroxylation of framework boron species via steaming not only enhances the ODHP rate on both B-MFI and B-BEA, but also impacts the kinetics of the reaction. The altered activity, propane reaction order and the activation energy could be attributed to the hydrolysis of framework [B(OSi≡)3] unit to [B(OSi≡)3−x(OH···O(H)Si≡)x] (x = 1, 2, “···” represents hydrogen bonding). DFT calculations confirm that hydroxylated framework boron sites could stabilize radical species, e.g., hydroperoxyl radical, further facilitating the gas-phase radical mechanism. Variations in the contributions from gas-phase radical mechanisms in ODHP lead to the linear correlation between activation enthalpy and entropy on borosilicate zeolites. Insights gained in this work offer a general mechanistic framework to rationalize the kinetic behavior of the ODHP on boron-based catalysts.
Low-dose lithium adjunct to atypical antipsychotic treatment nearly improved cognitive impairment, deteriorated the gray-matter volume, and decreased the interleukin-6 level in drug-naive patients with first schizophrenia symptoms: a follow-up pilot study
Authors: Zhuo Chuanjun , Hu Shuiqing , Chen Guangdong , Yang Lei , Cai Ziyao , Tian Hongjun , Jiang Deguo , Chen Chunmian , Wang Lina , Ma Xiaoyan , Li Ranli 
Published: October 2023

AbstractThis study was conducted to investigate the effects of long-term low-dose lithium adjunct to antipsychotic agent use on the cognitive performance, whole-brain gray-matter volume (GMV), and interleukin-6 (IL-6) level in drug-naive patients with first-episode schizophrenia, and to examine relationships among these factors. In this double-blind randomized controlled study, 50 drug-naive patients with first-episode schizophrenia each took low-dose (250 mg/day) lithium and placebo (of the same shape and taste) adjunct to antipsychotic agents (mean, 644.70 ± 105.58 and 677.00 ± 143.33 mg/day chlorpromazine equivalent, respectively) for 24 weeks. At baseline and after treatment completion, the MATRICS Consensus Cognitive Battery (MCCB) was used to assess cognitive performance, 3-T magnetic resonance imaging was performed to assess structural brain alterations, and serum IL-6 levels were quantified by immunoassay. Treatment effects were assessed within and between patient groups. Relationships among cognitive performance, whole-brain GMVs, and the IL-6 level were investigated by partial correlation analysis. Relative to baseline, patients in the lithium group showed improved working memory, verbal learning, processing speed, and reasoning/problem solving after 24 weeks of treatment; those in the placebo group showed only improved working memory and verbal learning. The composite MCCB score did not differ significantly between groups. The whole-brain GMV reduction was significantly lesser in the lithium group than in the placebo group (0.46% vs. 1.03%; P < 0.001). The GMV and IL-6 reduction ratios correlated with each other in both groups (r = −0.17, P = 0.025). In the lithium group, the whole-brain GMV reduction ratio correlated with the working memory improvement ratio (r = −0.15, P = 0.030) and processing speed (r = −0.14, P = 0.036); the IL-6 reduction ratio correlated with the working memory (r = −0.21, P = 0.043) and verbal learning (r = −0.30, P = 0.031) improvement ratios. In the placebo group, the whole-brain GMV reduction ratio correlated only with the working memory improvement ratio (r = −0.24, P = 0.019); the IL-6 reduction ratio correlated with the working memory (r = −0.17, P = 0.022) and verbal learning (r = −0.15, P = 0.011) improvement ratios. Both treatments implemented in this study nearly improved the cognitive performance of patients with schizophrenia; relative to placebo, low-dose lithium had slightly greater effects on several aspects of cognition. The patterns of correlation among GMV reduction, IL-6 reduction, and cognitive performance improvement differed between groups.
A model of conceptual bootstrapping in human cognition
Authors: Zhao Bonan , Lucas Christopher G. , Bramley Neil R. 
Published: October 2023

AbstractTo tackle a hard problem, it is often wise to reuse and recombine existing knowledge. Such an ability to bootstrap enables us to grow rich mental concepts despite limited cognitive resources. Here we present a computational model of conceptual bootstrapping. This model uses a dynamic conceptual repertoire that can cache and later reuse elements of earlier insights in principled ways, modelling learning as a series of compositional generalizations. This model predicts systematically different learned concepts when the same evidence is processed in different orders, without any extra assumptions about previous beliefs or background knowledge. Across four behavioural experiments (total n = 570), we demonstrate strong curriculum-order and conceptual garden-pathing effects that closely resemble our model predictions and differ from those of alternative accounts. Taken together, this work offers a computational account of how past experiences shape future conceptual discoveries and showcases the importance of curriculum design in human inductive concept inferences.
Magneto-acoustic protein nanostructures for non-invasive imaging of tissue mechanics in vivo
Authors: Kim Whee-Soo , Min Sungjin , Kim Su Kyeom , Kang Sunghwi , An Soohwan , Criado-Hidalgo Ernesto , Davis Hunter , Bar-Zion Avinoam , Malounda Dina , Kim Yu Heun , Lee Jae-Hyun , Bae Soo Han , Lee Jin Gu , Kwak Minsuk , Cho Seung-Woo , Shapiro Mikhail G. , Cheon Jinwoo 
Published: October 2023

AbstractMeasuring cellular and tissue mechanics inside intact living organisms is essential for interrogating the roles of force in physiological and disease processes. Current agents for studying the mechanobiology of intact, living organisms are limited by poor light penetration and material stability. Magnetomotive ultrasound is an emerging modality for real-time in vivo imaging of tissue mechanics. Nonetheless, it has poor sensitivity and spatiotemporal resolution. Here we describe magneto-gas vesicles (MGVs), protein nanostructures based on gas vesicles and magnetic nanoparticles that produce differential ultrasound signals in response to varying mechanical properties of surrounding tissues. These hybrid nanomaterials significantly improve signal strength and detection sensitivity. Furthermore, MGVs enable non-invasive, long-term and quantitative measurements of mechanical properties within three-dimensional tissues and in vivo fibrosis models. Using MGVs as novel contrast agents, we demonstrate their potential for non-invasive imaging of tissue elasticity, offering insights into mechanobiology and its application to disease diagnosis and treatment.
A high-quality chromosome-level wild rice genome of Oryza coarctata
Authors: Zhao Hang , Wang Wenzheng , Yang Yirong , Wang Zhiwei , Sun Jing , Yuan Kaijun , Rabbi S. M. Hisam Al , Khanam Munnujan , Kabir Md. Shahjahan , Seraj Zeba I. , Rahman Md. Sazzadur , Zhang Zhiguo 
Published: October 2023

AbstractOryza coarctata (2n = 4X = 48, KKLL) is an allotetraploid, undomesticated relative of rice and the only species in the genus Oryza with tolerance to high salinity and submergence. Therefore, it contains important stress and tolerance genes/factors for rice. The initial draft genome published was limited by data and technical restrictions, leading to an incomplete and highly fragmented assembly. This study reports a new, highly contiguous chromosome-level genome assembly and annotation of O. coarctata. PacBio high-quality HiFi reads generated 460 contigs with a total length of 573.4 Mb and an N50 of 23.1 Mb, which were assembled into scaffolds with Hi-C data, anchoring 96.99% of the assembly onto 24 chromosomes. The genome assembly comprises 45,571 genes, and repetitive content contributes 25.5% of the genome. This study provides the novel identification of the KK and LL genome types of the genus Oryza, leading to valuable insights into rice genome evolution. The chromosome-level genome assembly of O. coarctata is a valuable resource for rice research and molecular breeding.
The rise of macropredatory pliosaurids near the Early-Middle Jurassic transition
Authors: Sachs Sven , Madzia Daniel , Thuy Ben , Kear Benjamin P. 
Published: October 2023

AbstractThe emergence of gigantic pliosaurid plesiosaurs reshaped the trophic structure of Mesozoic marine ecosystems, and established an  ~ 80 million-year (Ma) dynasty of macropredatory marine reptiles. However, the timescale of their ‘defining’ trait evolution is incompletely understood because the fossil record of gigantic pliosaurids is scarce prior to the late-Middle Jurassic (Callovian),  ~ 165.3 Ma. Here, we pinpoint the appearance of large body size and robust dentitions to early-Middle Jurassic (Bajocian) pliosaurids from northeastern France and Switzerland. These specimens include a new genus that sheds light on the nascent diversification of macropredatory pliosaurids occurring shortly after the Early-Middle Jurassic transition, around  ~ 171 Ma. Furthermore, our multivariate assessment of dental character states shows that the first gigantic pliosaurids occupied different morphospace from coeval large-bodied rhomaleosaurid plesiosaurs, which were dominant in the Early Jurassic but declined during the mid-Jurassic, possibly facilitating the radiation and subsequent ecomorph acme of pliosaurids. Finally, we posit that while the emergence of macropredatory pliosaurids was apparently coordinated with regional faunal turnover in the epeiric basins of Europe, it paralleled a globally protracted extinction of other higher trophic-level marine reptiles that was not completed until after the earliest-Late Jurassic,  ~ 161.5 Ma.
Optimized polarization-independent Chand-Bali nano-antenna for thermal IR energy harvesting
Authors: Elsharabasy Ahmed Y. , Bakr Mohamed H. , Deen M. Jamal 
Published: October 2023

AbstractA novel, polarization-independent, wide-angle reception Chand-Bali nano-antenna is proposed. An adjoint-based optimization algorithm is used to create the same resonance at both linear polarizations of the incident radiation. The nano-antenna optimal parameters reveal that two hot spots with a strong field enhancement are created. These hot-spots could be integrated with metal–insulator–metal (MIM) diodes to form a rectenna for infrared (IR) energy harvesting. The metallic resonators allow for selecting several materials to facilitate the fabrication of the nano-antenna and the MIM diode. The Chand-Bali-based IR rectennas are investigated and simulations demonstrate an improvement of more than one order of magnitude in efficiency compared to ones using traditional nano-antennas.
Health assessment of rice cultivated and harvested from plasma-irradiated seeds
Authors: Okumura Takamasa , Tanaka Hayate , Nakao Takumi , Anan Teruki , Arita Ryo , Shiraki Masaki , Shiraki Kayo , Miyabe Tomoyuki , Yamashita Daisuke , Matsuo Kayo , Attri Pankaj , Kamataki Kunihiro , Yamashita Naoto , Itagaki Naho , Shiratani Masaharu , Hosoda Satoshi , Tanaka Akiyo , Ishibashi Yushi , Koga Kazunori 
Published: October 2023

AbstractThis study provides the health effects assessment of rice cultivated from plasma-irradiated seeds. The rice (Oryza sativa L.) cultivated from seeds with plasma irradiation showed a growth improvement (slope-ratios of with plasma to without plasma were 1.066, 1.042, and 1.255 for tiller, and earing, and ripening periods, respectively) and an 4% increase in yield. The cultivated rice was used for repeated oral administrations to mice for 4-week period. Distilled water and rice cultivated from seeds without plasma irradiation were also used as control. The weights of the lung, kidney, liver, and spleen, with corresponding average values of 0.22 g, 0.72 g, 2.1 g, and 0.17 g for w/ plasma group and 0.22 g, 0.68 g, 2.16 g, and 0.14 g for w/o plasma group, respectively, showing no effect due to the administration of rice cultivated from plasma-irradiated seeds. Nutritional status, liver function, kidney function, and lipid, neutral fat profiles, and glucose metabolism have no significant difference between with and without plasma groups. These results show no obvious subacute effects were observed on rice grains cultivated and harvested from the mother plant that experienced growth improvement by plasma irradiation. This study provides a new finding that there is no apparent adverse health effect on the grains harvested from the plasma-irradiated seeds.
Tumour area infiltration and cell count in endoscopic biopsies of therapy-naive upper GI tract carcinomas by QuPath analysis: implications for predictive biomarker testing
Authors: Scheel Andreas H. , Lamberty Hannah , Tolkach Yuri , Gebauer Florian , Schoemig-Markiefka Birgid , Zander Thomas , Buettner Reinhard , Rueschoff Josef , Bruns Christiane Josephine , Schroeder Wolfgang , Quaas Alexander 
Published: October 2023

AbstractGuidelines regulate how many (tumour-bearing) tissue particles should be sampled during gastric cancer biopsy to obtain representative results in predictive biomarker testing. Little is known about how well these guidelines are applied, how the number of tissue particles correlates with the actual tumour-infiltrated area and how many absolute tumour cells are captured. The study included endoscopic biopsies of untreated carcinomas of the upper gastrointestinal (GI)-tract during the 2016–2020 review period. Archival (H&E)-stained histological sections were digitised and the tumour areas were manually annotated. The tumour-bearing tissue area and absolute carcinoma cell count per case were determined by image analysis and compared with a reference primary surgical specimen. Biopsies from 253 patients were analysed. The following mean values were determined: (a) tumour tissue particle number: 6.5 (range: 1–25, standard deviation (SD) = 3.33), (b) number of tumour-bearing tissue particles: 4.7 (range: 1–20, SD = 2.80), (c) tumour-infiltrated area: 7.5 mm2 (range: 0.18–59.46 mm2, SD = 6.67 mm2), (d) absolute tumour cell count: 13,492 (range: 193–92,834, SD = 14,185) and (e) tumour cell count in a primary surgical specimen (tumour size: 6.7 cm): 105,200,176. The guideline-recommended tissue particle count of 10 was not achieved in 208 patients (82.2%) and the required tumour-bearing tissue particle count of 5 was not achieved in 133 patients (52.6%). Tissue particle count, tumour-infiltrated area and tumour cell count were only weakly correlated. Most cases featured an infiltrated area ≥ 4.5 mm2 (156, 61.7%). Cases with more tissue particles showed only a moderate increase in infiltrated area and tumour cells compared to cases with fewer particles. Biopsies are often used to determine predictive biomarkers, particularly Her2/neu and PD-L1. Diagnostic standards to ensure representative material have been suggested in guidelines to reduce false-negative predictions. However, the real-world practice seems to substantially deviate from recommended standards. To the best of our knowledge, this is the first systematic study describing the relationships between endoscopic tissue fragment number, actual infiltrated tumour area and carcinoma cell number. The data question the tissue particle number as a quality assessment parameter. We advocate histopathological reports indicating on which basis statements on therapy-relevant biomarkers were made. Digital pathology has the potential to objectively quantify the tissue for documentation, quality assessment and future clinical studies.
The J2 evolution model and control technology of the main roadway surrounding rock under superimposed influence of double-coal seam mining
Authors: Chen Dongdong , Li Zijian , Xie Shengrong , Wang Zhiqiang , Jiang Zaisheng , Jia Qingbo , Wang Yiyang 
Published: October 2023

AbstractUnder double-seam mining, the main roadway surrounding rock is affected by the superposition of the advanced stress of the two-seam coal working faces. The stress superposition mode and degree are of great significance to the width calculation of the protective coal pillar and the determination of the critical control direction of the surrounding rock. This paper uses theoretical analysis, numerical simulation, and site engineering practice to carry out targeted research. The conclusions are as follows: Under different lateral pressure coefficients, the superposition evolution law of maximum principal stress direction of two coal seams with different offsets; Two developmental trends and three types of evolution models of J2 peak zone (the critical area of the stress increase and deflection changes) under different superimposed loading modes are summarized. Based on the typical asymmetric evolution model of the J2 peak zone, an asymmetric truss-cable co-anchoring method is proposed aimed at the J2 critical zone. The field monitoring results show that the main roadway surrounding rock is stable after support when the upper coal seam protective coal pillar is left 80 m, and the lower one is 60 m wide. It is of great reference importance for similar engineering practices.
Perinatal events and development of juvenile idiopathic arthritis-associated uveitis
Authors: Chaudhary Aysha , Nadeem Manahil , Townsend Jack , Miller Victoria J. , Hajrasouliha Amir R. 
Published: October 2023

AbstractUveitis is one of the most common manifestations of juvenile idiopathic arthritis (JIA). Currently, JIA is associated with decreased gut microbiota diversity. Studies confirm that perinatal events can cause aberrant microbial colonization. The objective of this study is to determine if JIA is associated with perinatal events with a secondary focus on these variables to the development of JIA-uveitis. 369 patients with strabismus (n = 200) or JIA (n = 196) were included in the study. Completed surveys (JIA 37; strabismus 18) collected data about birth route, pregnancy and labor complications, JIA medications, and the presence of eye disorders. Analysis indicates that there is no relationship between JIA development and the perinatal events investigated. Similarly, no significance was found between JIA-uveitis and birth route or labor complications. Pregnancy complications, namely gestational diabetes (GD), were statistically higher in the JIA group with uveitis compared to JIA without uveitis. The data from this survey study showed that JIA-uveitis was highly associated with pregnancy complications, particularly with GD. However, no statistically significant association was found between JIA and route of delivery, labor complications, or pregnancy complications. Further studies are needed to understand the ways that GD interrelates with the development of uveitis in JIA patients.
Low-voltage ride-through capability in a DFIG using FO-PID and RCO techniques under symmetrical and asymmetrical faults
Authors: Sabzevari Kiomars , Khosravi Nima , Abdelghany Muhammad Bakr , Belkhier Youcef , Tostado-Véliz Marcos , Kotb Hossam , Govender Scott 
Published: October 2023

AbstractThe power grid faults study is crucial for maintaining grid reliability and stability. Understanding these faults enables rapid detection, prevention, and mitigation, ensuring uninterrupted electricity supply, safeguarding equipment, and preventing potential cascading failures, ultimately supporting the efficient functioning of modern society. This paper delves into the intricate challenge of ensuring the robust operation of wind turbines (WTs) in the face of fault conditions, a matter of substantial concern for power system experts. To navigate this challenge effectively, the implementation of symmetrical fault ride-through (SFRT) and asymmetrical fault ride-through (AFRT) control techniques becomes imperative, as these techniques play a pivotal role in upholding the stability and dependability of the power system during adverse scenarios. This study addresses this formidable challenge by introducing an innovative SFRT–AFRT control methodology based on rotor components optimization called RCO tailored for the rotor side converter (RSC) within a doubly-fed induction generator (DFIG) utilized in wind turbine systems. The proposed control strategy encompasses a two-fold approach: firstly, the attenuation of both positive and negative components is achieved through the strategic application of boundary constraints and the establishment of reference values. Subsequently, the optimization of the control characteristic ‘$$\beta$$
β
’ is accomplished through the utilization of a particle swarm optimization (PSO) algorithm integrated within an optimization loop. This intricate interplay of mechanisms aims to optimize the performance of the RSC under fault conditions. To measure the efficacy of the proposed control technique, a comparative analysis is conducted. Fractional-order (FO) proportional–integral–derivative (PID) controllers are employed as an additional method to complement the novel approach. By systematically juxtaposing the performance of the proposed SFRT–AFRT control technique with the FO-PID controllers, a comprehensive evaluation of the proposed approach's effectiveness is attained. This comparative assessment lends valuable insights into the potential advantages and limitations of the novel control technique, thereby contributing to the advancement of fault mitigation strategies in WT systems. Finally, the paper highlights the economic viability of the proposed control method, suggesting its suitability for addressing broader power network issues, such as power quality, in future wind farm research.
Determination of polycyclic aromatic hydrocarbons in bud-derived supplements by magnetic molecular imprinted microparticles and GC-MS: D-optimal design for a fast method optimization
Authors: Benedetti Barbara , Tronconi Arianna , Turrini Federica , Di Carro Marina , Donno Dario , Beccaro Gabriele Loris , Boggia Raffaella , Magi Emanuele 
Published: October 2023

AbstractWithin the world of natural food supplements, organic extracts deriving from young plant meristematic tissue (bud-derivatives) are becoming attractive, thanks to their richness in bioactive molecules. This natural source is scarce, but every year, tons of plant material, including buds, come from city pruning. If this sustainable source is rather promising from a circular economy point of view, the safety of the obtained supplements must be assessed. In fact, anthropic microcontaminants, such as polycyclic aromatic hydrocarbons (PAHs), could adsorb onto the urban buds, leading to a possible contamination of the bud-derivatives. In this study, we developed a magnetic dispersive solid phase extraction (m-dSPE) based on molecularly imprinted microparticles, combined with GC-MS, to quantify the 16 priority PAHs in such extracts. The D-optimal experimental design was implemented to maximize analytes’ recovery with the smallest set of experiments. The optimized method was characterized by great selectivity thanks to the molecular imprinted polymer and ease of use provided by m-dSPE. Moreover, it complies with green principles, thanks to the minimum consumption of organic solvent (1.5 mL of acetone per sample). The recoveries ranged from 76 to 100% and procedural precision was below 10% for most PAHs. Despite the matrix complexity, low quantification limits (0.7–12.6 μg kg−1) were reached. This guaranteed the PAHs’ quantitation at levels below those indicated as safe by a European Community regulation on food supplements. None of the analyzed samples, coming from different anthropically impacted areas, showed concerning PAHs levels.