bluuebunny/crossref_metadata_2025_split huggingface dataset:
Effects of aerobic exercise on neurocognitive function in postmenopausal women receiving endocrine therapy for breast cancer: The Exercise Program in Cancer and Cognition randomized controlled trial
Authors: Bender Catherine M. , Sereika Susan M. , Gentry Amanda L. , Cuglewski Cheryl , Duquette Jennie , Grove George , Cummings Meredith , Cho Myeong‐ga , Brufsky Adam M. , McAuliffe Priscilla , Budway Raye J. , Diego Emilia J. , Evans Steven , Rosenzweig Margaret Q. , Marsland Anna L. , Conley Yvette P. , Erickson Kirk 
Published: January 2024

AbstractObjectiveThe Exercise Program in Cancer and Cognition Study was a randomized controlled trial designed to determine whether 6 months of moderate‐intensity aerobic exercise improves neurocognitive function in women with breast cancer (BC) receiving endocrine therapy (ET).MethodsPostmenopausal women with hormone receptor+, early‐stage BC, within two years post‐primary therapy were randomized to the exercise intervention (six months, ≥150 min of moderate‐intensity aerobic exercise/week) or usual care control condition. Outcomes were assessed at pre‐randomization and after intervention completion. Groups were compared using linear mixed‐effects modeling.ResultsParticipants (N = 153) were = 62.09 ± 8.27 years old, with stage I BC (64.1%) and a median of 4.7 months post‐diagnosis. We found a group‐by‐time interaction (p = 0.041) and a trend for the main effect of time (p = 0.11) for processing speed with improved performance in the exercise group and no change in the controls. Similar main effects of time were observed for learning and memory (p = 0.024) and working memory (p = 0.01). Better intervention adherence was associated with improved processing speed (p = 0.017).ConclusionsSix months of moderate‐intensity aerobic exercise improves processing speed in postmenopausal women with BC receiving ET who initiate exercise within 2 years of completing primary therapy (surgery +/− chemotherapy). This is the first large‐scale study to examine the effects of aerobic exercise on neurocognitive function in women with BC. Additional research is needed to address the long‐term effects of aerobic exercise on cognitive function.
Synthesis and herbicidal activities of 2‐((3‐pyridinyl‐2‐oxo‐2,3‐dihydrobenzo[d]thiazol‐6‐yl)oxy)propionates
Authors: Chen Yu , Li Zhanbin , Huang Yuqian , Li Wenqi , Wei Shaopeng , Ji Zhiqin 
Published: January 2024

AbstractBACKGROUNDThe discovery of lead compounds is fundamental to herbicide innovation, yet the limited availability of valuable lead compounds has impeded their progress in recent years. The study presents a novel molecular scaffold that exhibits remarkably potent herbicidal activity.RESULTSThrough a scaffold‐hopping strategy, a highly potent lead compound for herbicides, namely 3‐(2‐pyridinyl)‐benzothiazol‐2‐one, was unexpectedly discovered during attempts to structurally modify haloxyfop, a commercial aryl‐oxy‐phenoxy‐propionate herbicide. To investigate the structure–activity relationship (SAR) of the newly discovered herbicidal chemicals, a series of 2‐(2‐oxo‐3‐(pyridin‐2‐yl)‐2,3‐dihydrobenzo[d]thiazol‐6‐yloxy)propanoic acid derivatives, I‐01 ~ I‐27, were designed and synthesized. SAR analysis revealed that trifluoromethyl at the 5‐position of pyridine is crucial for herbicidal activity, whereas additional fluorine or Cl atom at the 3‐position of pyridine significantly enhances activity. Carboxylic ester derivatives exhibit superior herbicidal activity compared with amide derivatives. Moreover, the activity of carboxylic ester derivatives decreases with C chain extension, but the introduction of O atoms in the side chain benefits activity enhancement. Pot experiments conducted in a glasshouse demonstrated that I‐01 and I‐09 exhibited potent postemergence herbicidal activity against broadleaf weeds, and completely inhibited growth of Amaranthus retroflex, Abutilon theophrasti and Portulaca oleracea at a dosage of 75 g ha−1.CONCLUSIONDespite the initial goal of scaffold‐hopping not being achieved, we have successfully identified a novel molecular scaffold exhibiting exceptional herbicidal activity, thereby presenting innovative prospects for herbicide development. © 2024 Society of Chemical Industry.
Degradation trajectory prediction of lithium‐ion batteries based on charging‐discharging health features extraction and integrated data‐driven models
Authors: Zheng Xiujuan , Wu Fei , Tao Liujun 
Published: January 2024

AbstractAs one of the key technologies in battery management system, accurate remaining useful life (RUL) prediction is critical to guarantee the reliability and safety for electrical equipment. However, the generalization and robustness of a single method are limited. A novel fusion data‐driven RUL prediction method CSSA‐ELM‐LSSVR based on charging‐discharging health features extraction is proposed in this paper, which fusions chaotic sparrow search algorithm (CSSA), extreme learning machine (ELM), and least squares support vector regression (LSSVR). First, four health indicators (HIs) are extracted from the charging‐discharging process, which can reflect the battery degradation phenomenon from multiple perspectives. Then, pearson correlation coefficient is used to numerically analyze the correlation between HIs and battery aging capacities. Second, the extracted HIs are used as the inputs for ELM and LSSVR to predict the degradation trend of battery, where CSSA is used for hyperparameters optimization in ELM. Finally, considering that CSSA‐ELM can capture the general trend of degradation curves, while LSSVR can trace the detail changes, a fusion framework based on CSSA‐ELM and LSSVR is proposed for RUL prediction. Two weighting schemes, namely precision‐based weighting (PW) and random forest regressor‐based weighting (RFRW) are put forward to fix the weights of CSSA‐ELM and LSSVR algorithms. Two publicly available datasets from National Aeronautics and Space Administration (NASA) and MIT are adopted to verify the feasibility and effectiveness of the proposed method. The results indicate that the proposed method with any weighting scheme has an overall superior prediction performance for different kinds of batteries compared with CSSA‐ELM, LSSVR, convolution neural network and long short term memory. Moreover, the RFRW scheme has better overall performance. Specifically, the maximum root mean square error of the predicted method is 2.5126%, the mean absolute percentage error is 12.9167%, the mean absolute error is 1.8376%, the predicted RUL errors are within one cycle, and the determination coefficient is above 0.97.
A Durable and High‐Voltage Mn–Graphite Dual‐Ion Battery Using Mn‐Based Hybrid Electrolytes
Authors: Cheng Zhenjie , Dong Qingyu , Pu Guiqiang , Song Junnan , Zhong Wenwu , Wang Jiacheng 
Published: January 2024

AbstractRechargeable Mn–metal batteries (MMBs) can attract considerable attention because Mn has the intrinsic merits including high energy density (976 mAh g−1), high air stability, and low toxicity. However, the application of Mn in rechargeable batteries is limited by the lack of proper cathodes for reversible Mn2+ intercalation/de‐intercalation, thus leading to low working voltage (<1.8 V) and poor cycling stability (≤200 cycles). Herein, a high‐voltage and durable MMB with graphite as the cathode is successfully constructed using a LiPF6‐Mn(TFSI)2 hybrid electrolyte, which shows a high discharge voltage of 2.34 V and long‐term stability of up to 1000 cycles. Mn(TFSI)2 can reduce the plating/stripping overpotential of Mn ions, while LiPF6 can efficiently improve the conductivity of the electrolyte. Electrochemical in‐situ characterization implies the dual‐anions intercalation/de‐intercalation at the cathode and Mn2+ plating/stripping reaction at the anode. Theoretical calculations unveil the top site of graphite is the energetically favorable for anions intercalation and TFSI− shows the low migration barrier. This work paves an avenue for designing high‐performance rechargeable MMBs towards electricity storage.
High vaccination coverage and infection rate result in a robust SARS‐CoV‐2‐specific immunity in the majority of liver cirrhosis and transplant patients: A single‐center cross‐sectional study
Authors: von der Schulenburg P. , Herting A. , Harberts A. , Lütgehetmann M. , Jahnke‐Triankowski J. , Pischke S. , Piecha F. , Drolz A. , Jörg V. , Hübener P. , Wehmeyer M. , Addo M. M. , Fischer L. , Lohse A. W. , Schulze Zur Wiesch J. , Sterneck M. 
Published: January 2024

AbstractBackgroundIn the third year of the SARS‐CoV‐2 pandemic, little is known about the vaccine‐ and infection‐induced immune response in liver transplant recipients (LTR) and liver cirrhosis patients (LCP).ObjectiveThis cross‐sectional study assessed the vaccination coverage, infection rate, and the resulting humoral and cellular SARS‐CoV‐2‐specific immune responses in a cohort of LTR and LCP at the University Medical Center Hamburg‐Eppendorf, Germany between March and May 2023.MethodsClinical and laboratory data from 244 consecutive patients (160 LTR and 84 LCP) were collected via chart review and a patient survey. Immune responses were determined via standard spike(S)‐ and nucleocapsid‐protein serology and a spike‐specific Interferon‐gamma release assay (IGRA).ResultsOn average, LTR and LCP were vaccinated 3.7 and 3.3 times, respectively and 59.4% of patients received ≥4 vaccinations. Altogether, 68.1% (109/160) of LTR and 70.2% (59/84) of LCP experienced a SARS‐CoV‐2 infection. Most infections occurred during the Omicron wave in 2022 after an average of 3.0 vaccinations. Overall, the hospitalization rate was low (<6%) in both groups. An average of 4.3 antigen contacts by vaccination and/or infection resulted in a seroconversion rate of 98.4%. However, 17.5% (28/160) of LTR and 8.3% (7/84) of LCP demonstrated only low anti‐S titers (<1000 AU/ml), and 24.6% (16/65) of LTR and 20.4% (10/59) of LCP had negative or low IGRA responses. Patients with hybrid immunity (vaccination plus infection) elicited significantly higher anti‐S titers compared with uninfected patients with the same number of spike antigen contacts. A total of 22.2% of patients refused additional booster vaccinations.ConclusionBy spring 2023, high vaccination coverage and infection rate have resulted in a robust, mostly hybrid, humoral and cellular immune response in most LTR and LCP. However, booster vaccinations with vaccines covering new variants seem advisable, especially in patients with low immune responses and risk factors for severe disease.
A literature review on satellite image time series forecasting: Methods and applications for remote sensing
Authors: Lara‐Alvarez Carlos , Flores Juan J. , Rodriguez‐Rangel Hector , Lopez‐Farias Rodrigo 
Published: January 2024

AbstractSatellite image time‐series are time series produced from remote sensing images; they generally correspond to features or indicators extracted from those images. With the increasing availability of remote sensing images and new methodologies to process such data, image time‐series methods have been used extensively for assessing temporal pattern detection, monitoring, classification, object detection, and feature estimation. Since the study of time series is broad, this article focuses on analyzing articles related to forecasting the value of one or more attributes of the image time‐series. The image time series forecasting (ITSF) problem appears in different disciplines; most focus on improving the quality of life by harnessing natural resources for sustainable development and minimizing the lethality of dangerous natural phenomena. Scientists tackle these problems using different tools or methods depending on the application. This review analyzes the field's leading, most recent contributions, grouping them by application area and solution methods. Our findings indicate that artificial neural networks, regression trees, support vector regression, and cellular automata are the most common methods for ITSF. Application areas address this problem as renewable energy, agriculture, and land‐use change. This study retrieved and analyzed relevant information about the recent activity of image time series forecasting, generating a reproducible list of the most pertinent articles in the field published from 2009 to 2021. To the author's best knowledge, this is the first review presenting and analyzing a reproducible list of the most relevant state‐of‐the‐art articles focusing on the applications, techniques, and research trends for ITSF.This article is categorized under:
Algorithmic Development > Spatial and Temporal Data Mining
Technologies > Machine Learning
Technologies > Prediction
Roots of Military Design
Authors: Trew Jason , Zweibelson Ben , Riggs Daniel 
Published: January 2024

Abstract“Design” is as ambiguous as a concept as it is pervasive as a practice. This chapter takes a “big history” approach to illustrate how humanity has used design, informally and formally, to realize advantages through its strategic use of imaginative, integrative thinking. Indeed, because the nature of design is expediency, skilled practitioners are particularly adept at navigating and nudging complex, “wicked” environments. Since security challenges may be the most complex and consequential of all human endeavors, the discipline of design – including its origin story and recent evolutions – is relevant to modern defense professionals.
Diffusion Enhancement and Taylor Dispersion for Rotationally Symmetric Flows in Discs and Pipes
Authors: Coti Zelati Michele , Dolce Michele , Lo Chia-Chun 
Published: January 2024

AbstractIn this note, we study the long-time dynamics of passive scalars driven by rotationally symmetric flows. We focus on identifying precise conditions on the velocity field in order to prove enhanced dissipation and Taylor dispersion in three-dimensional infinite pipes. As a byproduct of our analysis, we obtain an enhanced decay for circular flows on a disc of arbitrary radius.
Complemental Value of Microstructural and Macrostructural MRI in the Discrimination of Neurodegenerative Parkinson Syndromes
Authors: Schröter Nils , Arnold Philipp G. , Hosp Jonas A , Reisert Marco , Rijntjes Michel , Kellner Elias , Jost Wolfgang H. , Weiller Cornelius , Urbach Horst , Rau Alexander 
Published: January 2024

Abstract
Purpose
Various MRI-based techniques were tested for the differentiation of neurodegenerative Parkinson syndromes (NPS); the value of these techniques in direct comparison and combination is uncertain. We thus compared the diagnostic performance of macrostructural, single compartmental, and multicompartmental MRI in the differentiation of NPS.

Methods
We retrospectively included patients with NPS, including 136 Parkinson’s disease (PD), 41 multiple system atrophy (MSA) and 32 progressive supranuclear palsy (PSP) and 27 healthy controls (HC). Macrostructural tissue probability values (TPV) were obtained by CAT12. The microstructure was assessed using a mesoscopic approach by diffusion tensor imaging (DTI), neurite orientation dispersion and density imaging (NODDI), and diffusion microstructure imaging (DMI). After an atlas-based read-out, a linear support vector machine (SVM) was trained on a training set (n = 196) and validated in an independent test cohort (n = 40). The diagnostic performance of the SVM was compared for different inputs individually and in combination.

Results
Regarding the inputs separately, we observed the best diagnostic performance for DMI. Overall, the combination of DMI and TPV performed best and correctly classified 88% of the patients. The corresponding area under the receiver operating characteristic curve was 0.87 for HC, 0.97 for PD, 1.0 for MSA, and 0.99 for PSP.

Conclusion
We were able to demonstrate that (1) MRI parameters that approximate the microstructure provided substantial added value over conventional macrostructural imaging, (2) multicompartmental biophysically motivated models performed better than the single compartmental DTI and (3) combining macrostructural and microstructural information classified NPS and HC with satisfactory performance, thus suggesting a complementary value of both approaches.
Hydroxychloroquin – nicht immer ein harmloses Medikament für den Off-label-Gebrauch in der Dermatologie
Authors: Seidel Paloma , Spukti Eva , Steinbrink Kerstin , Metze Dieter , Böhm Markus 
Published: January 2024

ZusammenfassungHydroxychloroquin wird bei Entzündungserkrankungen eingesetzt und gilt als nebenwirkungsarm. Wir berichten über eine Patientin, die sich mit einem schweren Exanthem nach Einnahme von Hydroxychloroquin vorstellte, das sie im Rahmen eines Lichen planopilaris erhielt. Basierend auf klinischen, laborchemischen und histologischen Befunden, wurde die Diagnose einer DRESS(„drug reaction with eosinophilia and systemic symptoms“)-artigen Arzneimittelreaktion gestellt. Der Fall illustriert, dass Hydroxychloroquin in seltenen Fällen zu schweren unerwünschten Wirkungen führen kann und Patienten, die dieses Medikament nehmen, sorgfältig aufgeklärt werden müssen.
Evolution of cooperation in the indefinitely repeated collective action with a contest for power
Authors: Rosokha Yaroslav , Lyu Xinxin , Tverskoi Denis , Gavrilets Sergey 
Published: January 2024

AbstractSocial and political inequality among individuals is a common driving force behind the breakdown in cooperation. In this paper, we theoretically and experimentally study cooperation among individuals facing a sequence of collective-action problems in which the benefits of cooperation are divided according to political power that is obtained through a contest. We have three main results. First, we find that cooperation predictably responds to the fundamental parameters of the collective-action problem. Specifically, it is increasing in the benefit to cooperation and how much benefit is gained from partial group cooperation, and decreasing in the number of players. Second, we find that when players are unrestricted in their expenditures in the contest, cooperation is much lower than when expenditures are set to a specific proportion of earnings. Finally, we find that individual norms and beliefs account for a substantial proportion of explained variance in individuals’ decisions to cooperate.
Tumor characteristics of dissociated response to immune checkpoint inhibition in advanced melanoma
Authors: Versluis J. M. , Hoefsmit E. P. , Shehwana H. , Dimitriadis P. , Sanders J. , Broeks A. , Blank C. U. 
Published: January 2024

Abstract
Introduction
Immune checkpoint inhibition (ICI) has improved patients’ outcomes in advanced melanoma, often resulting in durable response. However, not all patients have durable responses and the patients with dissociated response are a valuable subgroup to identify mechanisms of ICI resistance.

Methods
Stage IV melanoma patients treated with ICI and dissociated response were retrospectively screened for available samples containing sufficient tumor at least at two time-points. Included were one patient with metachronous regressive and progressive lesions at the same site, two patients with regressive and novel lesion at different sites, and three patients with regressive and progressive lesions at different sites. In addition, four patients with acquired resistant tumor samples without a matched second sample were included.

Results
In the majority of patients, the progressive tumor lesion contained higher CD8+ T cell counts/mm2 and interferon-gamma (IFNγ) signature level, but similar tumor PD-L1 expression. The tumor mutational burden levels were in 2 out 3 lesions higher compared to the corresponding regressive tumors lesion.
In the acquired tumor lesions, high CD8+/mm2 and relatively high IFNγ signature levels were observed. In one patient in both the B2M and PTEN gene a stop gaining mutation and in another patient a pathogenic POLE mutation were found.

Conclusion
Intrapatient comparison of progressive versus regressive lesions indicates no defect in tumor T cell infiltration, and in general no tumor immune exclusion were observed.
Unexpected chronic lymphocytic leukemia B cell activation by bisphosphonates
Authors: Mazzarello Andrea N. , Gugiatti Elena , Cossu Vanessa , Bertola Nadia , Bagnara Davide , Carta Sonia , Ravera Silvia , Salvetti Chiara , Ibatici Adalberto , Ghiotto Fabio , Colombo Monica , Cutrona Giovanna , Marini Cecilia , Sambuceti Gianmario , Fais Franco , Bruno Silvia 
Published: January 2024

AbstractChronic lymphocytic leukemia (CLL) is a disease of the elderly, often presenting comorbidities like osteoporosis and requiring, in a relevant proportion of cases, treatment with bisphosphonates (BPs). This class of drugs was shown in preclinical investigations to also possess anticancer properties. We started an in vitro study of the effects of BPs on CLL B cells activated by microenvironment-mimicking stimuli and observed that, depending on drug concentration, hormetic effects were induced on the leukemic cells. Higher doses induced cytotoxicity whereas at lower concentrations, more likely occurring in vivo, the drugs generated a protective effect from spontaneous and chemotherapy-induced apoptosis, and augmented CLL B cell activation/proliferation. This CLL-activation effect promoted by the BPs was associated with markers of poor CLL prognosis and required the presence of bystander stromal cells. Functional experiments suggested that this phenomenon involves the release of soluble factors and is increased by cellular contact between stroma and CLL B cells. Since CLL patients often present comorbidities such as osteoporosis and considering the diverse outcomes in both CLL disease progression and CLL response to treatment among patients, illustrating this phenomenon holds potential significance in driving additional investigations.
Secondary central nervous system involvement in patients with diffuse large B-cell lymphoma treated with rituximab combined CHOP therapy – a supplementary analysis of JCOG0601
Authors: Shimada Kazuyuki , Ohmachi Ken , Machida Ryunosuke , Ota Shuichi , Itamura Hidekazu , Tsujimura Hideki , Takayama Nobuyuki , Shimada Takaki , Kurosawa Mitsutoshi , Tabayashi Takayuki , Shimoyama Tatsu , Ohshima Koichi , Miyazaki Kana , Maruyama Dai , Kinoshita Tomohiro , Ando Kiyoshi , Hotta Tomomitsu , Tsukasaki Kunihiro , Nagai Hirokazu 
Published: January 2024

Abstract
Secondary central nervous system involvement (sCNSi) in diffuse large B-cell lymphoma (DLBCL) is fatal. However, its features in patients with sCNSi who are categorized as lower risk by international prognostic index (IPI) or CNS-IPI are not yet fully understood. In the present analysis, we evaluated DLBCL patients who developed sCNSi at their first progression and who participated in JCOG0601, most of whom were lower risk by IPI. Of 409 patients, 21 (5.1%) developed sCNSi during a median follow-up of 4.9 years. Five-year cumulative incidence of sCNSi were 5.1%; and 4.0%, 5.3%, and 11.5% at low, intermediate, and high risk of CNS-IPI, respectively. The most common locations of extranodal lesions at the time of registration in patients with sCNSi were the stomach (n = 4), paranasal cavity (n = 3), and bone marrow (n = 2). In univariable analysis, paranasal cavity lesion was a high-risk factor for sCNSi (subdistribution hazard ratio, 4.34 [95% confidence interval 1.28–14.73]). Median overall survival after sCNSi was 1.3 years, with a 2-year overall survival rate of 39.3%. The incidence of sCNSi in DLBCL patients at lower risk of CNS-IPI was low, as previously reported, but paranasal cavity lesion might indicate high risk for organ involvement.

Clinical trial registration
JCOG0601 was registered in the UMIN Clinical Trials Registry (UMIN000000929, date of registration; December 04, 2007) and the Japan Registry of Clinical Trials (jRCTs031180139, date of registration; February 20, 2019).