bluuebunny/crossref_metadata_2025_split huggingface dataset:
Determination of Acrylamide in Coffee, Cereals, Baby Food, Cocoa, Dry Pet Food, Potato Products, Vegetable Crisps, Biscuits, Tea, Nuts, and Spices by LC-MS/MS in a Single-Laboratory Validation: First Action 2023.01
Authors: Bebius Aude , Reding Frédérique , Theurillat Viviane , Valérie Leloup , Konings Erik , Delatour Thierry , Desmarchelier Aurélien 
Published: January 2024

Abstract

Background
Acrylamide (AA) is a process contaminant naturally formed during the cooking of starchy food at high temperatures. Considering existing risks of misquantification inherent to the analysis of AA, an AOAC initiative raised the need for a consensus standard to determine AA in a broad variety of food.

Objective
A quantitative LC-MS/MS method for AA determination in food was validated in a single-laboratory study. Targeted performance requirements in terms of target matrixes, limit of quantification, recovery, and precision were as defined per Standard Method Performance Requirement (SMPR®) 2022.006.

Method
The proposed method derives from EN 16618:2015 standard pending modifications brought to the (1) sample preparation (simplified, potentially automated); (2) scope of application (significantly extended); and (3) LC conditions (improved selectivity). Confirmatory detection of AA is conducted by LC-MS/MS in the Selected Reaction Monitoring mode (SRM), and isotopic dilution was applied for quantification approach using either 2,3,3-d3-acrylamide (d3-AA), or 13C3-2,3,3-d3-acrylamide (13C3-d3-AA) as labeled internal standard.

Results
A total of 16 laboratory samples from nine matrix categories were included in the validation process. A full validation was conducted on coffee (instant, roast), infant cereal, cocoa powder, pet food (croquettes), tea (green tea), spices (black pepper), and nuts (roasted almonds) with satisfactory performances both in terms of recovery (97–108%) and precision (RSDr and RSDiR &lt;12%). The method applicability was further demonstrated through the analysis of quality control materials and reference materials including French fries, potato crisps, vegetable crisps, instant coffee, infant food, and biscuits (cookies), with accuracy values determined within a 94–107% range.

Conclusions
The performances of the presented method are in agreement with the acceptance criteria stipulated in SMPR 2022.006.

Highlights
The Expert Review Panel for acrylamide approved the present method as AOAC Official First Action 2023.01.
A Comparison of Teleburn to In-Person Consultation of Pediatric Patients in a Children’s Emergency Department
Authors: Ayers Claci , Byrd Hannah , Kidd Rebecca , Solomon Barbara , Gondek Stephen , Wagner Anne , Mubang Ronnie 
Published: January 2024

Abstract
Pediatric burn care is an essential component of emergency care and there are disparities in access to regional burn centers. Teleburn is a tool that enables providers without a certified burn center to provide photos of a burn to experts and receive recommendations. The purpose of this study is to evaluate the effectiveness of a Teleburn system to the in-person consultation regarding burn infection rate, clinic follow-up rate, postburn admission rate, and 72-h bounce back rate.
Data were collected from December 2019 to March 2022 through the electronic medical record. A total of 416 patient encounters that met the criteria were analyzed. A non-inferiority study was designed comparing proportional outcomes of Teleburn initial visits to emergency department visits regarding burn infection rate, clinic follow-up rate, postburn admission rate, and 72-h bounce back rate. The data were compared with a difference of greater than 10% being considered inferior.
No differences were identified in rates of readmission—1.67% difference (95% CI −27%&lt; x &lt; 23.8%) and return within 72 h—0.7% difference (−18.4%&lt; x &lt; 19.7%). Teleburn patients were 12.6% less likely to follow-up (2.7%&lt; x &lt; 22.40%). Only one infection was identified, which was insufficient to conclude non-inferiority.
While convenient, Teleburn consult could not be demonstrated to be non-inferior to in-person consultation. No differences in infection rates were identified, and differences in readmission and return were clinically insignificant. This study demonstrates that Teleburn may be effective and feasible for regional burn centers if follow-up can be improved.
The effect of gear-manufacturing quality on the mechanical and thermal responses of a polymer-gear pair
Authors: Zorko Damijan , Wei Peitang , Vukašinović Nikola 
Published: January 2024

Abstract
Gear-manufacturing quality affects the load sharing between the meshing gears as well as the load distribution along the width of the tooth. This study aims to investigate the effect of gear-manufacturing quality on the mechanical and thermal states of polymer-gear pairs and consequently on their lifetime. The deviations of the geometric quality parameters, i.e., the lead profile and pitch, were found to have a substantial effect on the stress (root and flank) state of the gear. The effect of the lead deviation was found to be most pronounced for the quality grades Q12 to Q10, where depending on the load, a 30–80% stress reduction was observed when improving the gear quality from Q12 to Q10. Improving the quality from Q10 to Q8 did not lead to a substantial improvement in the load distribution and the observed stress reduction was in range of 5–20%. Similar trends were found for the pitch deviation, where again the most pronounced stress reduction was seen when improving the quality grade from Q12 to Q10. The study reveals where the most effective changes, leading to an increased gear-life, can be achieved. Improving the gear quality grade from Q12 to Q11 proved to have a much more substantial effect than improving the gear quality from Q9 to Q8. Considering that improving the gear quality from Q12 to Q11 or even Q10 can be achieved by a proper tool design and corrective iterations with the right process parameters, while improving the quality from Q9 to Q8 is by far more challenging. A novel methodology is proposed to assess the effect of the gear’s quality on the generation of heat and the resulting operational temperature. The proposed methodology enables more accurate prediction of the gear pair’s operating temperature.
Internet-based cognitive rehabilitation for working cancer survivors: results of a multicenter randomized controlled trial
Authors: Klaver Kete M , Duijts Saskia F A , Geusgens Chantal A V , Kieffer Jacobien M , Agelink van Rentergem Joost , Hendriks Mathijs P , Nuver Janine , Marsman Hendrik A , Poppema Boelo J , Oostergo Tanja , Doeksen Annemiek , Aarts Maureen J B , Ponds Rudolf W H M , van der Beek Allard J , Schagen Sanne B 
Published: January 2024

Abstract

Background
Cognitive problems contribute to decline in work performance. We evaluated (1) the effectiveness of basic self-management and extensive therapist-guided online cognitive rehabilitation on attainment of individually predetermined work-related goals among occupationally active cancer survivors, and (2) whether effectiveness of the programs differed for survivors with and without formal cognitive impairment.

Methods
In a 3-arm randomized controlled trial (NCT03900806), 279 non–central nervous system cancer survivors with cognitive complaints were assigned to the basic program (n = 93), the extensive program (n = 93), or a waiting-list control group (n = 93). Participants completed measurements pre-randomization (T0), 12 weeks post-randomization upon program completion (T1), and 26 weeks post-randomization (T2). Mixed-effects modeling was used to compare intervention groups with the control group on goal attainment, and on self-perceived cognitive problems, work ability, and health-related quality of life.

Results
Participants in the extensive program achieved their predetermined goals better than those in the control group, at short- and long-term follow-up (effect size [ES] = .49; P &lt; .001; ES = .34; P = .014). They also had fewer recovery needs after work (ES = -.21; P = .011), more vitality (ES = .20; P = .018), and better physical role functioning (ES = .0.43 P = .015) than controls. At long-term follow-up, this finding persisted for physical role functioning (ES = .42; P = .034). The basic program elicited a small positive nonsignificant short-term (not long-term) effect on goal attainment for those with adequate adherence (ES = .28, P = .053). Effectiveness of the programs did not differ for patients with or without cognitive impairment.

Conclusions
Internet-based therapist-guided extensive cognitive rehabilitation improves work-related goal attainment. Considering the prevalence of cognitive problems in survivors, it is desirable to implement this program.
Trajectories and predictors of high-occurrence pain flares in ambulatory cancer patients on opioids
Authors: Meghani Salimah H , Quinn Ryan , Robinson Andrew , Chittams Jesse , Vapiwala Neha , Naylor Mary , Cheatle Martin , Knafl George J 
Published: January 2024

Abstract

Background
Pain flares have a substantive impact on the quality of life and well-being of patients with cancer. We identified longitudinal trajectories (clusters) of cancer pain flares in ambulatory patients and sociodemographic and clinical predictors of these trajectories.

Methods
In a prospective cohort study using ecological momentary assessment (mEMA), we collected patient-reported daily pain flare ratings data over 5 months and identified predictors and correlates using validated measures.

Results
The mean age of the sample (N = 270) was 60.9 years (SD = 11.2), 64.8% were female, and 32.6% self-identified as African American. Four pain flare clusters were identified. The “high-occurrence” cluster (23% of patients) experienced 5.5 (SD = 5.47) daily flares, whereas low-moderate clusters (77%) reported 2.4 (SD = 2.74) daily flares (P &lt; .000). Those in the high-occurrence cluster reported higher pain scores (P = .000), increased pain-related interference (P = .000), depressive symptoms (P = .023), lower quality of life (P = .001), and reduced pain self-efficacy (P = .006). Notably, 67.2% of those prescribed opioids as needed (PRN only) were in the high-occurrence pain flare cluster, compared with 27.9% with PRN and around-the-clock opioid prescriptions (P = .024). Individual predictors of high-occurrence pain flares were income below $30 000, unemployment, being African American, lower education level, Medicaid insurance, current opioid misuse (COMM), baseline inpatient hospital stay duration, and PRN-only opioid regimen. In the multiple predictor model, lower education level, unemployment, COMM score, extended inpatient duration, and PRN-only opioid regimen remained significant.

Conclusion
In ambulatory patients with cancer, high occurrence of pain flares may be mitigated by attention to opioid prescription factors and addressing social determinants of health needs of underserved patients.
Fatigue life and fatigue reliability mechanism of ball bearings
Authors: Cheng Hongchuan , Li Xinhai , Ma Guohui , Shi Xiafei , Yang Zhou 
Published: January 2024

Abstract
As the main supporting parts of rotating machinery, the fatigue life and fatigue reliability of ball bearings directly affect the accuracy, stability and reliability of equipment. Based on the quasi-static model of bearing and the fatigue life theory, this paper analyzes the effect of the external loads on the mechanical properties and fatigue life of bearing, and studies the action mechanism of bearing working conditions and other parameters. In addition, based on the stress–strength model and the fatigue life model of bearing, the fatigue reliability and sensitivity of bearings are analyzed by means of perturbation method, Edgeworth series and fourth moment technique, and the correctness is verified by the Monte Carlo simulation. Results have important theoretical and practical value, and can provide theoretical support for the research of reliability optimization design, fault mechanism and fault diagnosis method of ball bearings.
ω Centauri: a MUSE discovery of a counter-rotating core
Authors: Pechetti Renuka , Kamann Sebastian , Krajnović Davor , Seth Anil , van de Ven Glenn , Neumayer Nadine , Dreizler Stefan , Weilbacher Peter M , Martens Sven , Wragg Florence 
Published: January 2024

ABSTRACT
ω Centauri is considered the most massive globular cluster of the Milky Way and likely the former nuclear star cluster of a Galaxy accreted by the Milky Way. It is speculated to contain an intermediate-mass black hole (IMBH) from several dynamical models. However, uncertainties regarding the location of the cluster centre or the retention of stellar remnants limit the robustness of the IMBH detections reported so far. In this paper, we derive and study the stellar kinematics from the highest-resolution spectroscopic data yet, using the Multi Unit Spectroscopic Explorer (MUSE) in the narrow field mode and wide field mode. Our exceptional data near the centre reveal for the first time that stars within the inner 20 arcsec (∼0.5 pc) counter-rotate relative to the bulk rotation of the cluster. Using this data set, we measure the rotation and line-of-sight velocity dispersion profile out to 120 arcsec with different centres proposed in the literature. We find that the velocity dispersion profiles using different centres match well with those previously published. Based on the counter–rotation, we determine a kinematic centre and look for any signs of an IMBH using the high-velocity stars close to the centre. We do not find any significant outliers &gt;60 km s−1 within the central 20 arcsec, consistent with no IMBH being present at the centre of ω Centauri. A detailed analysis of Jeans’ modelling of the putative IMBH will be presented in the next paper of the series.
Multiwavelength detection of an ongoing FUOr-type outburst on a low-mass YSO
Authors: Guo Zhen , Lucas P W , Kurtev R G , Borissova J , Elbakyan Vardan , Morris C , Bayo A , Smith L , Caratti o Garatti A , Contreras Peña C , Minniti D , Jose J , Ashraf M , Alonso-García J , Miller N , Muthu H D S 
Published: January 2024

ABSTRACT
During the pre-main-sequence evolution, Young Stellar Objects (YSOs) assemble most of their mass during the episodic accretion process. The rarely seen FUOr-type events are valuable laboratories to investigate the outbursting nature of YSOs. Here, we present multiwavelength detection of a high-amplitude eruptive source in the young open cluster VdBH 221 with an ongoing outburst, including optical to mid-infrared time series and near-infrared spectra. The initial outburst has an exceptional amplitude of &gt;6.3 mag in Gaia and 4.6 mag in Ks, with a peak luminosity up to 16 L⊙ and a peak mass accretion rate of 1.4 × 10−5 M⊙ yr−1. The optical to infrared spectral energy distribution of this object is consistent with a low-mass star (0.2 M⊙) with a modest extinction (AV &lt; 2 mag). A 100-d delay between optical and infrared rising stages is detected, suggesting an outside-in origin of the instability. The spectroscopic features of this object reveal a self-luminous accretion disc, very similar to FU Orionis, with a low line-of-sight extinction. Most recently, there has been a gradual increase in brightness throughout the wavelength range, possibly suggesting an enhancement of the mass accretion rate.
Neuroinvasive Bacillus cereus Infection in Immunocompromised Hosts: Epidemiologic Investigation of 5 Patients With Acute Myeloid Leukemia
Authors: Little Jessica S , Coughlin Cassie , Hsieh Candace , Lanza Meaghan , Huang Wan Yi , Kumar Aishwarya , Dandawate Tanvi , Tucker Robert , Gable Paige , Vazquez Deida Axel A , Moulton-Meissner Heather , Stevens Valerie , McAllister Gillian , Ewing Thomas , Diaz Maria , Glowicz Janet , Winkler Marisa L , Pecora Nicole , Kubiak David W , Pearson Jeffrey C , Luskin Marlise R , Sherman Amy C , Woolley Ann E , Brandeburg Christina , Bolstorff Barbara , McHale Eileen , Fortes Esther , Doucette Matthew , Smole Sandra , Bunnell Craig , Gross Anne , Platt Dana , Desai Sonali , Fiumara Karen , Issa Nicolas C , Baden Lindsey R , Rhee Chanu , Klompas Michael , Baker Meghan A 
Published: January 2024

Abstract

Background
Bacillus cereus is a ubiquitous gram-positive rod-shaped bacterium that can cause sepsis and neuroinvasive disease in patients with acute leukemia or neutropenia.

Methods
A single-center retrospective review was conducted to evaluate patients with acute leukemia, positive blood or cerebrospinal fluid test results for B cereus, and abnormal neuroradiographic findings between January 2018 and October 2022. Infection control practices were observed, environmental samples obtained, a dietary case-control study completed, and whole genome sequencing performed on environmental and clinical Bacillus isolates.

Results
Five patients with B cereus neuroinvasive disease were identified. All patients had acute myeloid leukemia (AML), were receiving induction chemotherapy, and were neutropenic. Neurologic involvement included subarachnoid or intraparenchymal hemorrhage or brain abscess. All patients were treated with ciprofloxacin and survived with limited or no neurologic sequelae. B cereus was identified in 7 of 61 environmental samples and 1 of 19 dietary protein samples—these were unrelated to clinical isolates via sequencing. No point source was identified. Ciprofloxacin was added to the empiric antimicrobial regimen for patients with AML and prolonged or recurrent neutropenic fevers; no new cases were identified in the ensuing year.

Conclusions
B cereus is ubiquitous in the hospital environment, at times leading to clusters with unrelated isolates. Fastidious infection control practices addressing a range of possible exposures are warranted, but their efficacy is unknown and they may not be sufficient to prevent all infections. Thus, including B cereus coverage in empiric regimens for patients with AML and persistent neutropenic fever may limit the morbidity of this pathogen.
PRDM16 co-operates with LHX2 to shape the human brain
Authors: Suresh Varun , Bhattacharya Bidisha , Tshuva Rami Yair , Danan Gotthold Miri , Olender Tsviya , Bose Mahima , Pradhan Saurabh J , Zeev Bruria Ben , Smith Richard Scott , Tole Shubha , Galande Sanjeev , Harwell Corey C , Baizabal José-Manuel , Reiner Orly 
Published: January 2024

AbstractPRDM16 is a dynamic transcriptional regulator of various stem cell niches, including adipocytic, hematopoietic, cardiac progenitors, and neural stem cells. PRDM16 has been suggested to contribute to 1p36 deletion syndrome, one of the most prevalent subtelomeric microdeletion syndromes. We report a patient with a de novo nonsense mutation in the PRDM16 coding sequence, accompanied by lissencephaly and microcephaly features. Human stem cells were genetically modified to mimic this mutation, generating cortical organoids that exhibited altered cell cycle dynamics. RNA sequencing of cortical organoids at day 32 unveiled changes in cell adhesion and WNT-signaling pathways. ChIP-seq of PRDM16 identified binding sites in postmortem human fetal cortex, indicating the conservation of PRDM16 binding to developmental genes in mice and humans, potentially at enhancer sites. A shared motif between PRDM16 and LHX2 was identified and further examined through comparison with LHX2 ChIP-seq data from mice. These results suggested a collaborative partnership between PRDM16 and LHX2 in regulating a common set of genes and pathways in cortical radial glia cells, possibly via their synergistic involvement in cortical development.
Absolute properties of the oscillating eclipsing Algol XZ Ursae Majoris
Authors: Lee Jae Woo , Hong Kyeongsoo , Kim Hye-Young , Wolf Marek , Park Jang-Ho , Rittipruk Pakakaew 
Published: January 2024

Abstract
It is known from archival TESS data that the semi-detached Algol system XZ Ursae Majoris (UMa) is one of the candidate binary stars exhibiting short-period oscillations. We secured new high-resolution spectroscopic observations for the program target to better understand its binary and pulsation properties. From the echelle spectra, the radial velocities (RVs) of the eclipsing pair were derived, and the atmosphere parameters of the primary component were measured to be vAsin i = 80 ± 7 km s−1, Teff, A = 7940 ± 120 K, and [M/H] = −0.15 ± 0.20. The combined solution of our double-lined RVs and the TESS data provides robust physical parameters for XZ UMa with mass and radius measurement precision of better than 2%. The outside-eclipse residuals from a mean light curve in the 0.002 phase bin were used for multifrequency analyses, and we extracted 32 significant frequencies (22 in &lt;5.0 d−1 and 10 in 39–52 d−1). The low frequencies may be mostly aliasing sidelobes, while six of the high frequencies may be pulsation signals arising from the detached primary located inside the δ Sct domain. Their periods, pulsation constants, and pulsational–orbital-period ratios indicate that the mass-accreting primary star is a δ Sct pulsator and, hence, XZ UMa is an oscillating eclipsing Algol.
Search for Dark Energy with Neutron Interferometry
Authors: Fischer Hauke , Käding Christian , Lemmel Hartmut , Sponar Stephan , Pitschmann Mario 
Published: January 2024

Abstract
We use previously obtained experimental results by neutron interferometry to effectively constrain the parameter space of several prominent dark energy models. This investigation encompasses the environment-dependent dilaton field, a compelling contender for dark energy that emerges naturally within the strong coupling limit of string theory, alongside symmetron and chameleon fields. Our study presents substantial improvements over previous constraints of the dilaton and symmetron fields, improving parameter constraints by several orders of magnitude. However, the analysis does not yield any new constraints on the chameleon field. Furthermore, we establish constraints for the projected neutron split interferometer, which has recently concluded a decisive proof-of-principle demonstration. Our symmetron simulations reveal that, depending on the parameter values, there are multiple static solutions with an increasing number of nodes and increasing energy inside a cylindrical vacuum chamber. This agrees with results obtained earlier in the literature for infinitely extended parallel plates. Interestingly, while these multiple solutions can correspond to domain walls forming inside the vacuum chamber, we also find solutions that do not reach their vacuum expectation value inside the vacuum chamber, but display multiple nodes nonetheless.
Casimir Effect of Lorentz-Violating Charged Dirac Field in Background Magnetic Field
Authors: Rohim Ar , Romadani Arista , Adam Apriadi Salim 
Published: January 2024

Abstract
We study the effect of the Lorentz violation on the Casimir energy and pressure of a charged Dirac field in a background uniform magnetic field. In the model, the Lorentz violation is parameterized not only by the intensity but also by its direction. We investigate two cases of the direction of violation, namely, time-like and space-like vector cases. We use the boundary condition of the MIT bag model to represent the property of the plates. We show how the Lorentz violation and the magnetic field affect the structure of the Casimir energy and its pressure. We also investigate the weak and strong magnetic field cases with two different limits, heavy and light masses. In addition, we compute the ratio of the influence of the strong magnetic field to that of the weak one for the Casimir energy and its pressure. We find that the strong magnetic field enhances the magnitude of the Casimir energy and its pressure, where the parameter of the intensity of Lorentz violation could scale the plate’s distance.