bluuebunny/crossref_metadata_2025_split huggingface dataset:
Temperature‐dependent Raman and infrared spectra of nucleosides. III—deoxycytidine
Authors: Li J. , Lee S. A. , Anderson A. , Lettress L. , Griffey R. H. , Mohan V. 
Published: March 2003

AbstractRaman and infrared spectra were recorded for crystalline deoxycytidine samples at 300, 200, 100 and 10 K. Data were taken over the spectral range 20–4000 cm−1. The wavenumbers of most vibrational modes were found to increase as the temperature was lowered. A number of peaks split into multiplets at low temperature. A new mode, observed at 375 cm−1, is a marker band for 2′‐deoxyribose in cytosine‐containing nucleic acids. Evidence is presented supporting the assignment of marker bands associated with the C3′‐endo and C2′‐endo puckers of deoxyribose. No clear indication was found of any structural phase transitions in this temperature range. Several hydrogen‐stretching modes were found to involve hydrogen bonding. Plausible assignments of all the main features observed are suggested. Copyright © 2003 John Wiley & Sons, Ltd.
Adsorption and hydrogenation of benzene at platinum electrode surfaces probed by confocal Raman microscopy
Authors: Yao Jian‐Lin , Ren Bin , Liu Guo‐Kun , Wu De‐Yin , Gu Ren‐Ao , Tian Zhong‐Qun 
Published: March 2003

AbstractThe electrochemical adsorption and hydrogenation of benzene on a roughened Pt electrode were studied by confocal Raman microscopy. Some forbidden vibrational bands of benzene were detected owing to the lowering of the symmetry upon adsorption. The results infer that benzene is adsorbed on the Pt surface in a flat orientation by its ring. By comparison, its adsorption was carried out on an ultrathin Pt film‐coated Au electrode exhibiting higher SERS activity. It has been shown that benzene reacts with the adsorbed hydrogen, then is hydrogenated to cyclohexane on the Pt surface at negative potentials in acidic solution. This preliminary study provides evidence to support the fact that even weak adsorbates on pure transition metals can be studied by SERS spectroscopy. Copyright © 2003 John Wiley & Sons, Ltd.
Vibrational study of the superionic–protonic phase transition of (Cs)0.26(Rb)0.74H(SO4)0.89(SeO4)0.11
Authors: Kamoun S. , Gargouri M. 
Published: March 2003

AbstractRaman spectra (10–1300 cm−1) of polycrystalline samples of (Cs)0.26(Rb)0.74H(SO4)0.89(SeO4)0.11 were studied from 300 to 413 K. The νA–OH and νA–O (A = Se, S) bands were fitted by a Lorentzian function. The simulation of the νA–OH band allowed us to follow its evolution as a function of temperature. Above 383 K, the mixed compound exhibits a superionic phase transition. The activation energy which was determined from the plot of Δν1/2 versus temperature for the νA–OH band has the same order of magnitude as that determined from conductivity. Copyright © 2003 John Wiley & Sons, Ltd.
Postoperative taste and smell deficit after upper gastrointestinal cancer surgery—an unreported complication
Authors: Harris Adrian M. , Griffin S. Michael 
Published: March 2003

AbstractBackground and ObjectivesPatients undergoing upper gastrointestinal cancer surgery were noted to suffer loss of taste and/or smell, a previously unreported problem. Our aim was to investigate the extent of this phenomenon, quantify recovery time, and identify potentially associated factors.MethodsIn this retrospective study, a postal questionnaire was sent to all patients still alive after oesophagectomy or gastrectomy, with a minimum 1‐year follow‐up and no clinical or radiological evidence of recurrence. Data were analysed for prevalence of deficit in relation to operation, age, sex, respiratory complications, and disease stage.ResultsA total of 109/119 (92%) patients completed the questionnaire: 50 gastrectomies and 69 oesophagectomies. Ten patients were excluded with prior sensory deficit. Overall, 45/99 patients (45%) suffered deficit (M:F = 1.6:1). No association was found with type of surgery: deficits for subtotal gastrectomy, total gastrectomy, and oesophagectomy were 44, 46 and 46% respectively (χ2 = 0.355, 2 df P > 0.5). No other parameter was associated, and full recovery occurred in 30 patients (67%) within a mean of 6 months.ConclusionsLoss of taste and smell occurs in nearly one‐half of all cases after upper gastrointestinal surgery. The pathophysiology is unknown, but it resolves in most patients within 6–12 months. This complication should be discussed as part of informed consent for patients undergoing oesophagogastric cancer surgery. J. Surg. Oncol. 2003;82:147–150. © 2003 Wiley‐Liss, Inc.
Combined loss of expression of O6‐methylguanine‐DNA methyltransferase and hMLH1 accelerates progression of hepatocellular carcinoma
Authors: Matsukura Shiroh , Miyazaki Kohji , Yakushiji Hiroyuki , Ogawa Akiomi , Chen Yongxin , Sekiguchi Mutsuo 
Published: March 2003

AbstractBackground and ObjectivesO6‐methylguanine‐DNA methyltransferase (MGMT) and human Mut L homologue 1 (hMLH1) are proteins that play an important role in DNA repair. No reports have yet described whether deficient MGMT and hMLH1 expression correlates with tumor progression and the prognosis of patients with hepatocellular carcinoma (HCC).MethodsUsing immunohistochemical analysis, we evaluated the expression status of MGMT and hMLH1 protein in 60 paraffin‐embedded samples from consecutive patients with curatively resected HCC.ResultsThe lack of expression of both MGMT and hMLH1 in HCCs (n = 7) correlated with advanced pTNM stage (P = 0.039), as compared with HCCs expressing both proteins (n = 25). The absence of both MGMT and hMLH1 was a significant indicator of malignant potential. The expression status of both MGMT and hMLH1 was a predictive factor for overall survival in patients with HCC (P < 0.001).ConclusionsHCC lacking both MGMT and hMLH1 is correlated with an advanced stage and a poor prognosis. The expression status of both repair proteins is a predictive prognostic marker in patients with HCC after surgical resection. J. Surg. Oncol. 2003;82:194–200. © 2003 Wiley‐Liss, Inc.
Rapid reaction of sulfide with hydrogen peroxide and formation of different final products by freezing compared to those in solution
Authors: Takenaka Norimichi , Furuya Satoshi , Sato Keiichi , Bandow Hiroshi , Maeda Yasuaki , Furukawa Yoshinori 
Published: March 2003

AbstractThe reaction of sulfide with hydrogen peroxide in an aqueous solution at pH 9 produces thiosulfate, sulfite, and an unknown sulfur compound as intermediates, and, finally, all sulfides convert to sulfate (Chen and Gupta, Environ Lett 1973, 4, 187–200; Yokosuka et al., Nihon Kagaku Kaishi 1975, 11, 1901–1909; Hoffmann, Environ Sci Technol 1977, 11, 61–66; Ràbai et al., J Phys Chem 1992, 96, 5414–5419). This reaction was found to be accelerated by freezing. The decomposition rate of sulfide by H2O2 in freezing at −15°C was about 5 times faster than the maximum decomposition rate in solution at 25°C. The decomposition of sulfide by freezing obeys zero‐order kinetics, and the rate coefficient was 11.9 mol dm−3 min−1 at a freezing rate of 0.83 cm3 min−1. Zero‐order kinetics is one of the characteristics of freezing rate‐controlled reactions. Thiosulfate, sulfite, and an unknown sulfur compound were also observed as intermediates in the reaction by freezing. The decomposition of thiosulfate obeys first‐order kinetics, and the rate coefficient was 0.0496 min−1 at −15°C. The rate coefficient in freezing at −15°C is about 47 times faster than that in solution at 25°C. Sulfide, thiosulfate, and sulfite were consumed after 90 min. However, the unknown sulfur compound was not oxidized and was preserved in ice for a long time even in the presence of an excess of hydrogen peroxide. The concentration of an unknown sulfur compound in the frozen sample can be changed by changing the concentration of H2O2 and the pH of the solution. Freezing could be used for rapid preparation and preservation of unstable substances in solution. © 2003 Wiley Periodicals, Inc. Int J Chem Kinet 35: 198–205, 2003
Cancer “photo‐chemoprevention” with pulsed dye laser and celecoxib
Authors: Wang Zhi , Fuentes Cesar F. , Shapshay Stanley M. 
Published: March 2003

AbstractBackground and ObjectivesOur previous study demonstrated the efficacy of pulsed dye laser (PDL) in inhibiting cancer growth. This study is to determine the synergic effect of PDL and Celecoxib, when they are combined for treatment of oral cancer.Study Design/Materials and MethodsFifteen mice were inoculated with oral cell carcinoma and divided into three groups of five each (30 seeding sites/group): (1) control (no treatment), (2) PDL only, and (3) treatment with combined PDL and Celecoxib (1,500 ppm). The number and volume of tumors were counted and measured for 21 days.ResultsThe combined treatment developed tumor at the slowest rate. On day 21, the average tumor volumes were (1) 483.6 mm3 (control), (2) 312.1 mm3 (PDL only), and (3) 151.4 mm3 (combined treatment).ConclusionsA synergic effect was found in the combined treatment group. This study provides the first evidence of the efficacy of a new strategy for the treatment of oral cancer, namely, cancer “photo‐chemoprevention.” Lasers Surg. Med. 32:180–184, 2003. © 2003 Wiley‐Liss, Inc.
Preliminary biocompatibility experiment of polymer films for laser‐assisted tissue welding
Authors: Sorg Brian S. , Welch Ashley J. 
Published: March 2003

AbstractBackground and ObjectivesThe purpose of this study was to examine the impact of a polymer film for liquid solder strength reinforcement on the short term healing of a wound closed by laser‐tissue soldering.Materials and MethodsFull thickness incisions created on the dorsum of Sprague–Dawley rats were closed by laser‐tissue soldering: albumin solder with Indocyanine Green (ICG) dye was inserted between the incision edges and photothermally coagulated with a diode laser. A poly(DL‐lactic‐co‐glycolic acid) (PLGA) polymer film was implanted subcutaneously in the bottom of the incision (controls had no film). Specimens were harvested at 0, 3, 7, and 14 days for breaking strength testing and histological analysis.ResultsBreaking strengths of the controls at 0 and 14 days were statistically stronger than the specimens with the implanted films (t‐test, P < 0.05). A slight difficulty in apposing the wound edges due to the film presence may have contributed to the low acute strengths. Interference with the wound contraction process by the films possibly contributed to the lower breaking strength at 14 days. Wound histology indicated a mild foreign body reaction to the polymer film material.ConclusionsThe polymer film was well tolerated by the tissue, and the tissue response to the material was consistent with that seen in the literature. The breaking strength differences between control and film‐implanted specimens at 0 and 14 days were probably the result of mechanical complications (tissue apposition and wound contraction) due to the presence of the film, and not due to the film material itself. The use of polymer film patches for liquid solder reinforcement and breaking strength enhancement may have certain application specific issues that need to be addressed. Strategies to account for these issues require further research. Lasers Surg. Med. 32:215–223, 2003. © 2003 Wiley‐Liss, Inc.
A nonstandard density theorem for weak topologies on Banach and Bochner spaces
Authors: Vanderputten Laurent 
Published: March 2003

AbstractWe prove a nonstandard density result. It asserts that if a particular formula is true for functions in a set K of linear continuous functions between Banach spaces E and D, then it remains valid for functions that are limits, in the uniform convergence topology on a given class ℳ︁ of subsets of E, of nets of vectors in K. We then apply this result to various class ℳ︁ and setsK in the context of E‐valued Bochner integrable functions defined on a finite measure space.
Positive set‐operators of low complexity
Authors: Tzouvaras Athanossios 
Published: March 2003

AbstractThe powerset operator, 𝒫, is compared with other operators of similar type and logical complexity. Namely we examine positive operators whose defining formula has a canonical form containing at most a string of universal quantifiers. We call them ∀‐operators. The question we address in this paper is: How is the class of ∀‐operators generated ? It is shown that every positive ∀‐operator Γ such that Γ(∅︁) ≠ ∅︁, is finitely generated from 𝒫, the identity operator Id, constant operators and certain trivial ones by composition, ∪ and ∩. This extends results of [3] concerning bounded positive operators.
Addition‐Fragmentation Chain Transfer Involving Dimers of α‐Methylvinyl Monomers Studied by ESR Spectroscopy: Competition between Fragmentation and Bimolecular Termination
Authors: Zetterlund Per B. , Yamazoe Hirotomo , Yamada Bunichiro 
Published: March 2003

AbstractDetection of the adduct radical by ESR spectroscopy and after‐effect ESR measurements of the adduct radical concentrations in the photosensitized polymerization of styrene (St) in the presence of dimers of α‐methylstyrene (MSD) and methyl methacrylate have revealed that the dominant mechanism of adduct radical loss changes from bimolecular termination to fragmentation as the temperature is increased beyond 90 °C for St/MSD.
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Formation of Silica/Poly(p‐dioxanone) Microspheres by Surface‐Initiated Polymerization
Authors: Yoon Kuk Ro , Koh Young‐Joo , Choi Insung S. 
Published: March 2003

AbstractA polymeric film of a biodegradable poly(p‐dioxanone) was grown from 490 nm silica particles by monolayer formation via self‐assembly of hydroxy‐terminated triethoxysilane and subsequent surface‐initiated ring‐opening polymerization of p‐dioxanone. The resulting silica/poly(p‐dioxanone) hybrid particles were characterized by means of 1H NMR spectroscopy, IR spectroscopy, thermogravimetric analysis, field‐emission scanning electron microscopy, and energy‐dispersive X‐ray spectroscopy.
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Ultimately Specific 1,4‐cis Polymerization of 1,3‐Butadiene with a Novel Gadolinium Catalyst
Authors: Kaita Shojiro , Hou Zhaomin , Nishiura Masayoshi , Doi Yoshiharu , Kurazumi Junko , Horiuchi Akira C. , Wakatsuki Yasuo 
Published: March 2003

AbstractNovel complexes [(C5Me5)2Ln][B(C6F5)4] (Ln = Pr, Nd, or Gd) were prepared, which in combination with iBu3Al efficiently induce highly 1,4‐cis‐specific polymerization of butadiene. The activity of the Gd complex/iBu3Al system is high enough to exhibit good catalytic activity even at low temperature. Polymerization at −78 °C gave polybutadiene with nearly perfect 1,4‐cis microstructure (>99.9%) with sharp molecular weight distribution (Mw/Mn = 1.45) and in reasonable yield.
ORTEP drawing of 2b. Selected bond distances (Å): Pr‐F1 = 2.549(2), Pr‐F19 = 2.625(2).magnified imageORTEP drawing of 2b. Selected bond distances (Å): Pr‐F1 = 2.549(2), Pr‐F19 = 2.625(2).
Hepatocyte growth factor, transforming growth factor α, and their receptors as combined markers of prognosis in hepatocellular carcinoma
Authors: Daveau Maryvonne , Scotte Michel , François Arnaud , Coulouarn Cédric , Ros Gilles , Tallet Yveline , Hiron Martine , Hellot Marie‐France , Salier Jean‐Philippe 
Published: March 2003

AbstractA change in the balance between proliferation and apoptosis in the course of hepatocellular carcinoma (HCC) development and progression has been suspected. We wanted to identify related genes whose mRNA levels could provide markers of severity and prognosis after resection. The extent of cell apoptosis, proliferation, and differentiation was measured with a terminal deoxynucleotidyl transferase–mediated deoxyuridine 5‐triphosphate–biotin nick‐end labeling assay, and the Ki‐67 index was determined in paired tumor and cirrhotic tissue samples from patients who had undergone HCC resection after diagnosis of hepatitis C–related or alcoholism‐related cirrhosis. These patients included two groups with highly versus poorly differentiated tumor cells, and the latter was split into two subgroups of those with versus without early recurrence. The mRNA levels for various apoptosis‐related or proliferation‐related genes and those for the growth factor/receptor systems were measured by quantitative reverse transcriptase–polymerase chain reaction in paired tumor and cirrhotic liver samples from every patient, and some of the corresponding proteins were detected by immunohistochemistry. In all instances, protein expression was highly heterogeneous within groups and similar between groups. In contrast, some differences in mRNA level between tumor and cirrhotic tissues were quite informative. Low levels of hepatocyte growth factor and transforming growth factor α mRNAs were found concomitantly in highly differentiated tumors, whereas overexpression of mRNAs for the cognate receptors c‐met and epidermal growth factor receptor were found in poorly differentiated tumors and primarily in patients with early tumor recurrence. These results argue for growth factor–dependent HCC development and provide novel and combined prognosis markers after HCC surgery. © 2003 Wiley‐Liss, Inc.
Primary orthostatic tremor associated with a persistent cerebrospinal fluid monoclonal IgG band
Authors: Trip S. Anand , Wroe Stephen J. 
Published: March 2003

AbstractPrimary orthostatic tremor is of unknown aetiology and is believed to be a distinct entity rather than a subtype of essential tremor. We describe the first patient with a typical phenotype of primary orthostatic tremor who has a persistent isolated monoclonal immunoglobulin G band in the cerebrospinal fluid. © 2002 Movement Disorder Society
Late delayed postradiation spinal myoclonus or psychogenic movement disorder?
Authors: Löscher Wolfgang N. , Trinka Eugen 
Published: March 2003

AbstractWe describe a patient with intermittent, at times rhythmic trunk flexion movements. Neurophysiological assessment excluded a psychogenic movement disorder. The segmental spinal myoclonus occurred 6 years after radiation therapy of the brain and entire spinal cord, and we suggest this patient to be the first case of a late‐delayed sequela of spinal cord irradiation presenting as segmental spinal myoclonus. © 2002 Movement Disorder Society
Changes of GABA receptors and dopamine turnover in the postmortem brains of parkinsonians with levodopa‐induced motor complications
Authors: Calon Frédéric , Morissette Marc , Rajput Ali H. , Hornykiewicz Oleh , Bédard Paul J. , Di Paolo Thérèse 
Published: March 2003

AbstractBrain samples from 14 Parkinson's disease patients, 10 of whom developed motor complications (dyskinesias and/or wearing‐off) on dopaminomimetic therapy, and 11 controls were analyzed. Striatal 3β‐(4‐125I‐iodophenyl)tropane‐2β‐carboxylic acid isopropyl ester ([125I]RTI‐121) ‐specific binding to dopamine transporter and concentration of dopamine were markedly decreased, but no association between level of denervation and development of motor complications was observed. The homovanillic acid/dopamine ratio of concentrations was higher in putamen of patients with wearing‐off compared to those without. Striatal 35S‐labeled t‐butylbicyclophosphorothionate ([35S]TBPS) and [3H]flunitrazepam binding to GABAA receptors were unchanged in patients with Parkinson's disease, whereas [125I]CGP 64213 ‐specific binding to GABAB receptors was decreased in the putamen and external segment of the globus pallidus of parkinsonian patients compared with controls. [3H]Flunitrazepam binding was increased in the putamen of patients with wearing‐off compared to those without. [35S]TBPS–specific binding was increased in the ventral internal globus pallidus of dyskinetic subjects. These data suggest altered dopamine metabolism and increased GABAA receptors in the putamen related to the pathophysiology of wearing‐off. The present results also suggest that an up‐regulation of GABAA receptors in the internal globus pallidus is linked to the pathogenesis of levodopa‐induced dyskinesias. © 2002 Movement Disorder Society
Cerebral amyloid angiopathy and motor neurone disease presenting with a progressive supranuclear palsy‐like syndrome
Authors: Weeks Robert A. , Scaravilli Francisco , Lees Andrew J. , Carroll Camille , Husain Masud , Rudge Peter 
Published: March 2003

AbstractWe describe a 68‐year‐old woman who presented with falls, mild limb bradykinesia, axial rigidity, and a severe supranuclear gaze palsy, which failed to benefit from levodopa. She subsequently developed severe apraxia, progressive dysarthria, dysphagia, and a frontal cognitive impairment. Pyramidal weakness with fasciculations and widespread chronic partial denervation appeared shortly before her death from bronchopneumonia, 6 months after disease onset. A severe cerebral amyloid angiopathy diffusely involving the cerebral hemispheres and cerebellum was present at autopsy as well as a second pathological condition indicative of motor neurone disease. Cerebral amyloid angiopathy may rarely present with a progressive supranuclear palsy–like phenotype.
Rating scales for dystonia: A multicenter assessment
Authors: Comella Cynthia L. , Leurgans Sue , Wuu Joanne , Stebbins Glenn T. , Chmura Teresa ,   and The Dystonia Study Group
Published: March 2003

AbstractThe evaluation of dystonia requires a reliable rating scale. The widely used Fahn‐Marsden Scale (F‐M) has not been sufficiently tested across multiple centers and investigators. The Dystonia Study Group developed the Unified Dystonia Rating Scale (UDRS) and a Global Dystonia Rating Scale (GDS) to serve as instruments to assess dystonia severity. In this study, 25 dystonia experts evaluated the UDRS, F‐M, and GDS for internal consistency and reliability. One hundred dystonia patients were videotaped using a standardized videotape protocol. Each examiner rated 20 patients using the UDRS, F‐M, and GDS in random order. The examiner then assessed each scale for ease of use. Statistical analysis used Cronbach's α, intraclass correlation coefficients (ICC), generalized weighted κ statistic, and Kendall's coefficient of concordance. The UDRS, F‐M, and GDS showed excellent internal consistency (Cronbach's α 0.89–0.93) and good to excellent correlation among the raters (ICC range from 0.71–0.78). Inter‐rater agreement was fair to excellent (Kendall's 0.54–0.87; κ 0.37–0.91) being lowest for eyes, jaw, face, and larynx. The modifying ratings (Duration in the UDRS and Provoking Factor in the F‐M) showed less agreement than the motor severity ratings. Among scales, the total scores correlated (Pearson's r, 0.977–0.983). Overall, 74% of raters found the GDS the easiest to apply. The GDS with its simplicity and ease of application may be the most useful dystonia rating scale. © 2002 Movement Disorder Society
HLA typing does not predict REM sleep behaviour disorder and hallucinations in Parkinson's disease
Authors: Onofrj Marco , Luciano Anna Lisa , Iacono Diego , Thomas Astrid , Stocchi Fabrizio , Papola Franco , Adorno Domenico , Di Mascio Rocco 
Published: March 2003

AbstractHLA‐DR2 haplotype and DQ1 DNA alleles, characterizing 90 to 100% of all narcoleptic patients, were found to be equally distributed in 20 Parkinson's disease (PD) patients with early hallucinations, rapid eye movement (REM) sleep‐related behaviour disturbances (RBD), and sleep onset in REM (SOREM), and in 20 PD patients without hallucinations, despite 10 to 15 years of treatment, and no RBD or SOREM.