bluuebunny/crossref_metadata_2025_split huggingface dataset:
Provider Assessment of the Temporomandibular Joint in Juvenile Idiopathic Arthritis: A Retrospective Analysis from the CARRA Database
Authors: Costello Anna , Twilt Marinka , Lerman Melissa 
Published: January 2024

Abstract
Background:
Temporomandibular joint (TMJ) involvement is an often underrecognized complication of juvenile idiopathic arthritis (JIA) that can cause decreased mandibular growth, altered facial morphology, and orofacial pain. It is estimated that the TMJ is affected in 40–80% of children with JIA. Standardized physical examination and imaging evaluations are important in accurately assessing active TMJ arthritis and sequalae. Little is known about the rate at which providers evaluate TMJ involvement in their clinical practice.
Methods:
Data were obtained from the Childhood Arthritis and Rheumatology Research Alliance (CARRA) Registry. Data fields related to assessment for TMJ arthritis were added in 2019. Patients were included in the study if they had a diagnosis of JIA and had data recorded between January 2020 and August 2021. Standard descriptive statistics were used to describe demographic and clinical features.
Results:
A total of 17761 visits were reviewed for a total of 7473 patients with JIA. A total of 52.7% of patients had maximal mouth opening (MMO) recorded as finger breadths or total incisal distance (TID). Only 8% had TID measured. A total of 5.0% had MRI with contrast performed. A total of 939 patients had a diagnosis of TMJ arthritis. Of these, 28.5% had an MRI documented, 83% had an MMO documented, and 40% had TID measured. Few patient-level characteristics were statistically related to having MMO assessed. MRI was more likely to be obtained in older and in female patients. MMO was recorded at a given visit > 80% of the time at 17 sites, and it was recorded < 1% of the time at 8 sites. MRIs were infrequently performed at all sites, with 27 sites having no MRIs obtained and only 7 sites having an MRI obtained at > 10% of visits.
Conclusions:
MMO is not consistently measured in patients with JIA, and it is rarely measured quantitatively. Similarly, TMJ MRIs are rarely obtained in patients with JIA. Site of care is more associated with TMJ assessments than patient-level characteristics. These data suggest that provider education is needed to improve the assessment of the TMJ in patients with JIA to enable earlier recognition and prevent long-term complications.
Chiral Terahertz Control via Curvature and Regioselective-Enhanced Reconfigurable Metasurfaces
Authors: Lee Jaebeom , Gwak Juyong , Kang Hyojin , Kim Young-Mi , Lee Gyuseok , Nguyen Huu-Quang , Jeong Ki-Jae , Choi Yujin , Shin Hee Jun , Cho Youngjin , Goddati Mahendra , Chen Hongxia , Ok Gyeongsik 
Published: January 2024

Abstract
Advancements in terahertz (THz) wave photonics necessitate the development of cost-effective and easily manufacturable reconfigurable metasurfaces for dynamically controlling chiral THz frequency shifts. This article introduces two-step innovative approaches to address this need. The first involves integrating a regioselective assembly of magnetoplasmonic nanoparticles (MagPlas NPs) onto a flexible Ni-magnetized metasurface, creating new meta-atoms that induce various resonant frequencies. The second approach integrates curvature with a doped meta-atom to establish easily modifiable chiral systems, thereby enhancing the chiral THz response. The curvature introduces structural asymmetry, disrupting reflection symmetry across the metasurface's symmetry plane, specifically within the split rings. The positions (x, y, z) of the split rings along the curvature can be expressed as symmetry breaking of metasurface=Σi=1n F (xi, yi, zi, ωu). When the new meta-atom, regioselective split ring undergoes symmetry breaking due to curvature, the nanoparticles (NPs) act as a lattice, inducing surface lattice resonances (SLR) upon interaction with THz beams and causing strong optical asymmetric interactions. The engineered metasurface using curvature and regioselective assembly has been investigated in terms of enhanced transmittance and reconfigurable chirality by employing various NPs such as Ag@Fe3O4 NPs, Void@Fe3O4 NPs, and Au@Fe3O4 nanorods. By leveraging concepts such as symmetry breaking, magnetized resonators, regioselective magnetic arrangements, and metasurface-enhanced THz response, our study presents a compelling avenue for exerting essential transmittance control and frequency shift over emerging chiral THz reconfigurable systems.
The inhibitory control characteristic of children with attention-deficit/hyperactivity disorder with emotional dysregulation: evidence from event-related potentials (ERPs)
Authors: Li Sixun , Huang Yan , Yang Yanping , Wang Zhuo , Luo Tingting , Wang Meiwen , Situ Mingjing , Liu Pei , Yuan Jiajin , Huang Yi 
Published: January 2024

Abstract
Objective
Attention-deficit/hyperactivity disorder (ADHD) is the most prevalent neurodevelopmental condition in children. Emotion dysregulation (ED) exacerbates functional impairment severity in children with ADHD, and previous research suggests that ED may be linked to inhibition control deficits.
Method
We utilized the Anxiety/Depression, Aggression, and Attention scales of the CBCL (CBCL-DESR) to categorize participants into three groups: ADHD with emotion dysregulation (ADHD with DESR, n = 15), ADHD without emotion dysregulation (ADHD without DESR, n = 22), and Typical Development Children (TDC, n = 35). The Two-Choice Oddball task was employed to assess inhibitory control characteristics and record synchronous ERP. Repeated measures ANOVA and multiple linear regression was used to analysis the relationship between inhibition control deficit and emotion dysregulation.
Results
In the measurement of behavioral inhibit control functioning, we found that ADHD patients had a lower overall response accuracy than TDC. ADHD patients with emotion dysregulation had even longer overall response time than ADHD without emotion dysregulation and TDC. The original waveform analysis showed the larger amplitude for deviant stimuli than for standard stimuli in ADHD with emotional dysregulation group and lower amplitude for ADHD with emotional dysregulation than for ADHD without emotional dysregulation and TDC groups in deviant stimuli. The deviation-standard difference wave analysis showed that the N2 difference wave of ADHD with emotion dysregulation group was significantly larger that of ADHD without emotional dysregulation and TDC groups and we find inhibitory control-related EEG indicators (N2, P3) in predicting emotional dysregulation in ADHD patients.
Conclusions
ADHD children with emotional dysregulation showed more severe inhibitory control impairment on behavioral indicators, and differential N2 amplitude together with differential P3 amplitude can predict ADHD children with emotional dysregulation independently. The results could provide enlightening evidence for early detection and intervention targets in this subtype of children with ADHD.
Integrative Analyses of Bulk and Single-cell Transcriptomics Reveals The Infiltration and Crosstalk of Cancer-Associated Fibroblasts As a Novel Predictor for Prognosis and Microenvironment Remodeling in Intrahepatic Cholangiocarcinoma
Authors: Zhong Yan-Jie , Luo Xi-Mei , Liu Fei , He Zhi-Qiang , Yang Si-Qi , Ma Wen-Jie , Wang Jun-Ke , Dai Yu-Shi , Zou Rui-Qi , Hu Ya-Fei , Lv Tian-Run , Li Fu-Yu , Hu Hai-Jie 
Published: January 2024

Abstract

Background

Intrahepatic cholangiocarcinoma (ICC) is a highly malignant neoplasm and characterized by desmoplastic matrix. The heterogeneity and crosstalk of tumor microenvironment remain incompletely understood.

Methods

To address this gap, we performed Weighted Gene Co-expression Network Analysis (WGCNA) to identify and construct a cancer associated fibroblasts(CAFs) inflitration biomarker. We also depicted the intercellular communication network and important receptor-ligand complexes using the single-cell transcriptomics analysis of tumor and Adjacent normal tissue.

Results

EVA1A, APBA2, LRRTM4, GOLGA8M and BPIFB2 were identified as candidate CAFs-infiltration biomarker in Intrahepatic cholangiocarcinoma. The risk model derived from these markers displayed satisfactory performance. Additionally, our study also depicted the cell communication atlas between fibroblast and other cells. Especially, the signal transduction from fibroblasts to malignant cells via different pathways obviously enhanced, which subsequently trigger cascade activation of their downstream signaling pathways in tumor cells, such as PI3K-AKT and Notch pathways, regulating epithelial-mesenchymal transformation and invasion.

Conclusions

This study reveals the close association between fibroblasts infiltration and poor prognosis of intrahepatic cholangiocarcinoma. Enhanced intercellular transduction from fibroblasts to other cells and activated abnormal signaling pathways in tumor may give rise to microenvironment remodeling and tumor progression.
Compound Shenma Jingfu Granule alleviates cerebral ischemia via HIF-1α-mediated promotion of angiogenesis
Authors: He Ruihua , Xu Yi , Liu Jingxue , Liu Jing , Chen Jing , Wang Xufang , Qiu Lei , Huang Jin 
Published: January 2024

Abstract
Background
Shenma Jingfu Granule, a traditional Chinese medicine formula, has been used clinically for the treatment of cerebral circulation insufficiency. However, the mechanism involved in alleviating cerebral ischemia has not yet been fully elucidated.
Methods
An integrated approach involving network pharmacology and transcriptomics was utilized to clarify the potential mechanisms of SMJF Granule. Molecular docking and surface plasmon resonance (SPR) were employed to identify potential targets and ingredients of SMJF Granule. The anti-CI effect of SMJF Granule was determined on the middle cerebral artery occlusion (MCAO) model by using hematoxylin-eosin (H&E) and Nisslʼs staining, as well as triphenyl tetrazolium chloride (TTC) staining, and the potential targets involved in the mechanisms were validated by RT-qPCR and western blotting.
Results
Integrated analysis revealed the mechanism of SMJF Granule intervening in CI injury might be related to the HIF-1 signaling pathway and angiogenesis. Molecular docking and SPR assays demonstrated robust binding interactions between key compounds like salvianolic acid A and naringenin with the core target HIF-1α protein. The experiment confirmed that SMJF Granule lowered neurological scores, diminished infarct volume, and alleviated histopathological changes in vivo. The possible mechanism of SMJF Granule was due to regulating HIF-1 pathway, which contributed to up-regulating expression of VEGF and vWF in the penumbral region, showing a significant promotion of angiogenesis.
Conclusion
SMJF Granule alleviated cerebral ischemia injury through the HIF-1α/VEGF pathway. In addition, our findings provide some evidence that SMJF Granule is a candidate compound for further investigation in treating CI in the clinical.
Undernutrition and Associated Factors among Under-five Children in Batu Town, Oromia Regional State, Ethiopia: A community-based cross-sectional study
Authors: Hussen Amane , Ferede Amsal , Yalew Aster , Urgi Dawit , Habte Limenih , Ejara Daba 
Published: January 2024

Abstract

Enhancing nutrition significantly contributes to addressing sustainable development goals by reducing poverty. In Ethiopia, undernutrition is the leading cause of child illness and death. This study aimed to assess the prevalence and associated factors of undernutrition among children under-five years of age in Batu Town, Oromia, Ethiopia. A community-based cross-sectional study design with a simple random sampling technique was used to select 387 participants. ENA for SMART 2020 software was used to calculate the Z-score of Anthropometric Measurements. Binary logistic regression was employed to analyze the data and the outputs are presented using adjusted odds ratio with 95% confidence intervals (AOR, 95% CI). The magnitude of wasting, stunting, and underweight were 7.0%, 55.5%, and 27.0%, respectively. Being male [AOR = 1.86 (95% CI = 1.13–3.08)] and breastfeeding for over two years [AOR = 2.49 (95% CI = 1.22–5.12)] were the significant predictors of being underweight, whereas colostrum intake [AOR = 0.37 (95% CI = 0.15–0.94)] and good dietary diversity status [AOR = 0.45 (95% CI = 0.24–0.84)] were preventive factors. Similarly, colostrum intake [AOR = 0.09, (95% CI = 0.01–0.68])] and good dietary diversity status [AOR = 0.55 (95% CI = 0.33–0.94)] were preventive factors for stunting though children above 12 months [AOR = 2.89 (95% CI = 1.82–4.58] had increased odds of being stunted. However, in this study, family size [AOR = 3.54, 95% CI = 1.19–10.48] was the sole risk factor for wasting. Undernutrition was prevalent in Batu Town, exceeding regional and national rates. Boys are more affected. Moderate underweight and severe stunting are common. Breastfeeding, colostrum, and diversified diets help, while family size and child age increase the risk. To enhance children's nutritional status, tailored interventions such as promoting colostrum intake, and encouraging diversified diets are required.
Performance of stone covers on runoff and erosion in rainfed areas
Authors: Narsimlu Boini , Mishra P. K. 
Published: January 2024

Abstract

The performance of stone cover on infiltration, runoff, erosion and sediment yield during overland flow were quantified using a hydraulic tilting flume under two different discharges with four different slopes (0.1, 1.0, 3.0, and 5%). Two surface conditions were tested: bare soil and partial stone-cover (50%) arranged in two strips. Stone cover reduced flow velocity, decreased outflow, increased infiltration and reduced soil erosion compared to bare soil. Stone cover was most effective at reducing discharge when the flow depth was less than the median particle diameter, but was effective at reducing sediment yield for both flow depths. Stone cover prevented rill erosion above 3% slope. Infiltration decreased with increasing slope due to lower ponding depths on steeper slope. Sediment concentration increased with an increase in slope even with stone cover. In the case of bare soil, sediment concentration showed an exponential increase with increase in slope. Stone cover was effective in increasing infiltration rate of overland flow by decreasing flow velocity, but only when flow depth was less than or equal to median particle diameter. By contrast, stone cover reduced erosion and sediment load at both flow depths. Models of infiltration rate and sediment transport capacity were calibrated with the observed data for use in other modeling applications.
Experimental study regarding the surface roughness of circular crystal wafers sliced by a multi-wire saw with reciprocating and rocking functions
Authors: lin zhishu , Huang Hui , Li Shengbo 
Published: January 2024

Abstract

At present, wire sawing technology is the primary slicing method used for certain brittle materials, including monocrystalline silicon, sapphire, and silicon carbide. The surface quality of the sawn wafers significantly impacts subsequent machining processes, such as grinding and polishing. A theoretical model was developed to predict the amount of material removed per unit length of wire during the slicing of circular workpieces by a wire saw with reciprocating and rocking functions. Experiments were conducted during this study in which crystal ingots were sliced using a multi-wire saw, and the amount of material removed per unit length of wire was determined at different cutting positions on the workpiece cross-section. The surface roughness of each crystal wafer was measured systematically. The experimental results revealed that the surface roughness values measured at different points at the same y-coordinate position on a single wafer were approximately equal. However, the surface roughness was greatest on both the initial and final cutting edges and gradually decreased toward the wafer center. The surface roughness was also greatest for the wafer cut nearest to the new wire side, though it gradually decreased for wafers cut nearer to the center of the workpiece and remained relatively consistent from the middle wafer to the wafer cut nearest to the used wire side. The results also indicated that both the material removed per unit length of wire and the surface roughness of the wafer decreased with increases in the wire speed. The relationship between the material removed per unit length of wire and the surface roughness was approximately linear. When the material removed per unit length of wire was set to 0.00333 mm³/m, the average wafer surface roughness was 0.45 µm.
Charting the Cascade of Physical Activities: Implications for Reducing Sitting Time and Obesity in Children
Authors: Esmaeilzadeh Samad , Hakala Pirjo , Berg Päivi , Salmon Jo , Rinne Tiina , Pesola Arto J 
Published: January 2024

Abstract

Objective
Traditional intensity-based physical activity measures and variable-centered statistics may not fully capture the complex associations between sitting time, physical activity, and obesity indices. This study investigates the associations between device-measured sitting, standing and different modes of physical activity (i.e., slow walking, brisk-walking, cycling and high-intensity activity) and measured body mass index (BMI) in children using person-based latent profile analyses and Partial Least Squared-structural equation modeling (PLS-SEM).
Methods
A total of 344 children (11.5 ± 0.81 years, boys n = 139) wore a triaxial accelerometer (Fibion®) on their thigh for eight days, and their weight and height were measured at school. Latent profile analysis formed profiles including BMI, total sitting time, and physical activities, and their associations were further studied with PLS-SEM.
Results
The latent profile analysis indicates that high levels of physical activity always coincide with low sitting time. Both normal weight and overweight/obesity can coexist with low physical activity and prolonged sitting. The PLS-SEM results highlight a cascade-like sequence in the relationship between various types of physical activity, sitting time, and BMI. This sequence begins with light-intensity activities, such as standing, progresses to higher-intensity activities, and ultimately through reduced sitting time, mediates a decline in BMI. The most positive effects on sitting time and BMI occur when this pattern is adhered to consistently, suggesting that omitting steps could negatively impact the associations.
Conclusion
These findings suggest that persuading children to increase physical activity incrementally, starting from low-intensity activities such as standing and slow walking to activity types with higher intensities, possibly influence BMI by mediating reduced sitting time. This approach is particularly inclusive for overweight and obese children, taking into account the potential challenges they may encounter when performing activity types with high intensity. These cross-sectional associations need to be verified with longitudinal and experimental designs.
An AI-based cell segmentation pipeline for studying immune markers from brightfield microscopy images
Authors: Köhler Miriam , Reiss Yvonne , Macas Jadranka , Cakmak Pinar , Flinner Nadine , Imkeller Katharina , Lun Jennifer H. , Schupp Jonathan , Starzetz Tatjana , Moorthy Nivetha Krishna , Plate Karl H. , Schulz Marcel H. 
Published: January 2024

Abstract
Background: Cell segmentation is a essential task in analysing the tumormicroenvironment (TME), which encompasses vascular cells and cells of theinnate and adaptive immune system in and around the tumor. The impact of theTME on survival and effectiveness of immune therapies has been shown fordifferent tumor types e.g. gliomas.
Methods: Here, we developed an AI-based pipeline to analyse the TME inbrightfield microscopy images created by immunohistochemistry (IHC) applying CD3, CD4, CD8, CD20, CD163 and Iba1 antibodies. The pipeline consist offiltering the tumor areas by a residual neural network with 34 layers andsegmenting the immune and non-immune cells by a U-net based model.
Results: For most of the cell types, a filtering classifier trained on all cell typeshad a better performance than a classifier trained on one cell type. For the cellsegmentation, the segmentation classifier used in the pipeline outperformed thestate-of-the-art method Cellpose and Watershed as classical approach.
Conclusions: This AI-based cell segmentation pipeline can be used to analysethe TME of a big set of whole slide images without manual effort and toinvestigate the relationship between immune cells and survival in several tumortypes. One slide can be analysed in about 30 minutes, thus the pipeline has thepotential to be used in routine clinical diagnosis and could provide informationfor therapy suggestions.
An AIEE-active triphenylethylene derivative with photoresponsive character for latent fingerprints detection via a simple soaking method
Authors: Li Maomao , Zhu Wenjie , Song Dong-Dong , Liang Zuoqin , Ye Chang-qing 
Published: January 2024

Abstract
Latent fingerprints (LFPs) is one of the most important physical evidence in the criminal scene, playing an important role in forensic investigations. Therefore, developing highly sensitive and convenient materials for the visualization of LFP is of great significance. We designed and synthesized an organic fluorescent molecule TP-PH with aggregation-induced enhanced emission (AIEE) activity. By simply soaking, blue fluorescent images with high contrast and resolution are readily developed on surfaces including tinfoil, steel, glass and plastic. Remarkably, LFPs can be visualized within 5 minutes including the first-, second- and tertiary-level details. In addition, TP-PH exhibits interesting photoactivated fluorescence enhancement properties. Under irradiation by 365 nm UV light with a power density of 382 mW/cm2, the fluorescence quantum yield displays approximately 21.5-fold enhancement. Mechanism studies reveals that the photoactivated fluorescence is attributed to the irreversible cyclodehydrogenation reactions under UV irradiation. This work provides a guideline for the design of multifunctional AIE fluorescent materials.