bluuebunny/crossref_metadata_2025_split huggingface dataset:
Matching-Adjusted Indirect Comparison of the Efficacy of Tralokinumab and Dupilumab in the Treatment of Moderate-to-Severe Atopic Dermatitis Beyond Week 16
Authors: Torres Tiago , Sohrt Petersen Anne , Rosso Aldana Mariela , Moreira Taveira Christian , Carrascosa José Manuel 
Published: January 2024

Introduction: Tralokinumab and dupilumab are both licensed for the treatment of moderate-to-severe AD. However, to date no head-to-head studies or indirect comparisons of their efficacy beyond week 16 have been conducted.
Objective: To conduct a matching-adjusted indirect comparison (MAIC) comparing the efficacy of tralokinumab and dupilumab beyond week 16, both used in combination with topical corticosteroids.
Methods: An unanchored MAIC was conducted using individual patient data (IPD) from the ECZTRA 3 tralokinumab trial and aggregate data from the LIBERTY AD CHRONOS dupilumab trial. IPD were selected by applying the inclusion criteria from the LIBERTY AD CHRONOS trial, then weighted to match summary baseline characteristics – age, sex, race, BMI, disease duration, EASI, DLQI, IGA and SCORAD– of patients treated with dupilumab. Tralokinumab efficacy outcomes at week 32 were compared with dupilumab data at week 32 (EASI and IGA only) and week 52.
Results: Baseline characteristics of the matched tralokinumab arm were well balanced with the dupilumab arm. Tralokinumab and dupilumab showed comparable efficacy across all endpoints. The matched proportions of patients achieving IGA 0/1 were larger for tralokinumab patients at week 32 (49.9%) compared with dupilumab patients at week 32 (39.3%) and week 52 (36.0%). The matched differences in IGA 0/1 at weeks 32 and 52 were 10.6% (95% CI: −2.9%, 24.0%; p = 0.12) and 13.9% (95% CI: 0.6%, 27.3%; p = 0.04), respectively. For EASI 75, the proportion of responders was equivalent for tralokinumab and dupilumab (both 71.9%) at week 32 (difference 0%; 95% CI: −12.2%, 12.3%; p = 1.00). The proportion of EASI 75 responders was numerically lower for dupilumab (65.2%) at week 52 compared with tralokinumab at week 32, giving a difference of 6.8% (95% CI: −5.9%, 19.5%; p = 0.3).
Conclusion: These results confirm broadly similar efficacy for tralokinumab and dupilumab beyond week 16.
Laboratory Parameters in Adolescent Patients Aged 12–17 with Moderate-to-Severe Atopic Dermatitis Treated with Tralokinumab Up to Week 52: Results from the Phase 3 ECZTRA 6 Trial
Authors: Paller Amy , Cork Michael , Hong Chih-ho , Soong Weilly , Schneider Shannon , Lo Hannah , Pedersen Line Rosendahl Meldgaard , Vacko Emilia , Wollenberg Andreas 
Published: January 2024

Introduction: Tralokinumab, a high-affinity, monoclonal antibody that targets IL-13, is approved in the EU and Canada for adolescents (aged ≥12 years) with inadequately controlled moderate-to-severe atopic dermatitis (AD), and it does not require laboratory monitoring. The phase 3 ECZTRA 6 (NCT03526861) clinical trial demonstrated efficacy and safety up to 52 weeks in that population.
Objective/Purpose: To further characterize the safety profile of tralokinumab by evaluating laboratory parameters of adolescents in the ECZTRA 6 trial.
Methods: ECZTRA 6 subjects received tralokinumab 150mg (n=98), 300mg (n=97) or placebo (n=94) every 2 weeks (Q2W) from week 0–16 after a loading dose at week 0 (twice the subsequent dose), and then randomized to maintenance [original tralokinumab dose either Q2W or every 4 weeks (Q4W) or placebo Q2W] or open-label (tralokinumab 300mg Q2W) until week 52. Laboratory parameters included hematology, serum biochemistry, and urinalysis throughout the trial (weeks 0, 8, 16, 28, and 52).
Results: Overall (n= 289 subjects), laboratory baseline parameters were similar across treatment groups. Mean and median changes of most hematology parameters showed minor fluctuations within the normal ranges through week 52, except for eosinophils. At baseline, elevated mean eosinophil counts (>0.5 109/L) were observed for 40.8% (tralokinumab 150mg), 48.5% (tralokinumab 300mg), and 43.6% (placebo) of subjects in each respective treatment group. Some tralokinumab-treated patients had small transient increases in eosinophils (maximum mean change from baseline 0.2×109/L) before week 16. Continued treatment with tralokinumab or placebo did not correspond with further increase in eosinophil levels over time, and no adverse events of eosinophilia were reported. Mean levels of most biochemistry parameters, including electrolytes, renal and liver function parameters, and lipid panel, were within normal range at baseline, and mean and median changes showed minor fluctuations within normal ranges in all treatment arms. Mean lactate dehydrogenase levels were around or above the upper limit of normal at baseline and decreased to within the normal ranges during the trial across all groups. Overall, no clinically meaningful differences were observed in hematology, biochemistry, or urinalysis parameters between active treatment groups or placebo.
Conclusions: Similar to findings in adult trials, no meaningful changes in laboratory parameters were observed in adolescents through week 52 with tralokinumab treatment. No routine laboratory monitoring is needed for adult or adolescent AD patients treated with tralokinumab.
Les critères de l’art au risque du numérique. L’œuvre-réseau
Authors: Colas-Blaise Marion 
Published: January 2024

Quels sont les critères de l’art dans le cas d’une œuvre numérique ? Dans cet article, il s’agit de montrer que les critères de l’art traditionnels doivent être questionnés, voire dépassés, quand l’attention se porte non seulement sur la matérialité de l’œuvre numérique, sur sa texture, mais encore sur le geste et le processus techniques, qui peuvent être qualifiés de beaux, plutôt que sur l’objet esthétique lui-même. Le mouvement est accentué par les NFT (Non-fungible tokens, jetons non fongibles) : nous visons à vérifier l’hypothèse qu’en étant déployés sur des blockchains et impliqués dans des échanges de droits de propriété, ces derniers mettent en avant des modes inédits d’acquisition, de stockage et de consultation, qui font patrimoine à leur tour. Plus particulièrement, on se demandera en quoi l’art contemporain prépare et annonce l’art numérique. Il s’agit également de distinguer l’œuvre-réseau numérique du réseau scientifique.
Chevauchements art - street skate : les conditions d’existence d’un « méta-mode » artistique
Authors: Lenoël Anne-Cécile 
Published: January 2024

Cet article s’intéresse aux modalités de l’agir et du créer du street skate. Nous considérons que les pratiques des skateurs possèdent les temporalités d’une praxis et d’une aesthesis qui interfèrent de manière plurielle dans l’urbain. Le street skate ne conçoit pas que des espaces alternatifs (Lenoël 2016), il tisse des liens ténus avec les champs de l’art. Par une approche transversale skate-art, nous recherchons des marqueurs poïétiques des « choses artistiques » du skateboard. Plus que les limites, nous observerons ces phénoménalités artistiques par le prisme de la notion de chevauchement. Celle-ci désigne en effet une zone interstitielle signifiante pour étudier la densité syntaxique et sémantique que le skateboard peut donner à la ville.
Examining the Impact of Student Self-Efficacy on Motivation for Academic Achievement in Islamic Religious Education Subject
Authors: Anisah Nurul 
Published: January 2024

At SMP Negeri 1 Bojong, significant academic and non-academic accomplishments have been consistently attained and maintained, cultivating students' self-efficacy and inspiring them to strive for excellence, fostering healthy competition within the school environment. This study aims to achieve three primary objectives: (1) assess the level of self-efficacy, (2) evaluate the degree of motivation for achievement, and (3) investigate the impact of self-efficacy on achievement motivation. Employing a quantitative research approach and utilizing ex post facto research methods, the study results reveal the following: (1) Self-efficacy falls within the moderate category, as evidenced by an average score of 79.80556 within the range of 71.7 - 87.8, (2) Achievement motivation also resides in the moderate category, with an average score of 79.77778 within the range of 70.36 - 89.19, and (3) A significant influence of self-efficacy on achievement motivation is established, supported by the T-test results (Sig. 0.000 <0.05 and Tcount 7.563 > Ttable 2.032), leading to the rejection of the null hypothesis (Ho) in favor of the alternative hypothesis (Ha). This relationship is further confirmed by the F-test (Sig. 0.000 <0.05 and Fcount 57.206 > Ftable 4.12), again rejecting Ho in favor of Ha. The simple linear regression test results, with an Fcount value of 57.206 and a significance level of 0.000 <0.05, demonstrate a correlation (R) value of 0.792 and a coefficient of determination (R Square) of 0.627. These findings indicate that the independent variable (self-efficacy) exerts a significant 62.7% influence on the dependent variable (achievement motivation).
Respons Pertumbuhan dan Hasil Mentimun (Cucumis sativus L.) pada Kombinasi Media Substrat dengan Sistem Hidroponik
Authors: Aini Nurul , Muzakiyah Efi Zulfita 
Published: January 2024

Karakteristik media (bukan tanah) yang menjadi faktor yang penting dalam budidaya tanaman mentimun dengan sistem hidroponik substrat. Tujuan dari penelitian ini yaitu mempelajari pengaruh kombinasi media yang berasal dari limbah baglog jamur tiram, sekam dan arang sekam terhadap pertumbuhan dan hasil mentimun pada sistem hidroponik substrat. Percobaan disusun berdasarkan Rancangan Kelompok Lengkap Teracak (RKLT) dengan 3 ulangan. Perlakuan terdiri dari 9 kombinasi Media yaitu Limbah baglog jamur (100%), Sekam padi (100%), Arang sekam (100%), dan kombinasinya dengan masing-masing perbandingan 25:75; 50:50 dan 75: 25%. Hasil penelitian menunjukkan bahwa mentimun yang ditanam pada kombinasi media limbah baglog jamur + arang sekam (25:75) menghasilkan luas daun, jumlah daun, bobot kering, volume akar serta bobot dan jumlah buah yang lebih tinggi dibandingkan pada media limbah baglog jamur 100%. Hasil ini didukung dengan perbaikan sifat fisik media (porositas, ruang udara), serapan dan kandungan unsur hara dalam media. Kesimpulannya, agar menjadi media yang ideal, limbah baglog jamur sebaiknya dikombinasikan dengan arang sekam dengan perbandingan 25:75.
Kata kunci: Limbah baglog, nutrisi, porositas, volume akar
Inisiasi Kalus Bangle (Zingiber purpureum Roscoe) pada Beberapa Kombinasi 2.4-D dan Kinetin
Authors: Tarigan Swary Dwi Suherna , Astarini Ida Ayu , Astiti Ni Putu Adriani 
Published: January 2024

Bangle (Zingiber purpureum Roscoe) termasuk keluarga Zingiberaceae yang dimanfaatkan sebagai tanaman obat. Penelitian bertujuan untuk mengetahui pengaruh 2.4-D dan kinetin pada inisiasi kalus bangle. Penelitian dilaksanakan di Laboratorium Kultur Jaringan Tumbuhan, Prodi Biologi, Fakultas MIPA, Universitas Udayana dari bulan Februari hingga bulan Mei 2023. Desain percobaan yaitu Rancangan Acak Lengkap (RAL) dua faktor dan lima ulangan. Faktor pertama konsentrasi 2.4-D (0, 1 dan 2 ppm) dan faktor kedua konsentrasi kinetin (0, 0.5 dan 1 ppm). Variabel yang diamati meliputi waktu inisiasi kalus, persentase pembentukan kalus, dan morfologi kalus. Hasil penelitian menunjukkan 1 ppm 2.4-D - 0.5 ppm kinetin menghasilkan waktu inisiasi kalus tercepat (10.8 HST) dan persentase pembentukan kalus tertinggi (100%), sementara 1 ppm 2.4-D - 0.5 ppm kinetin dan 2 ppm 2.4-D - 0.5 ppm kinetin menghasilkan morfologi kalus yang baik dan embriogenik (warna putih dengan tekstur remah).
Kata Kunci: auksin, sitokinin, tanaman obat, Zingiberaceae
Penggunaan Sensor Kelembaban Tanah untuk Penetapan Jadwal Penyiraman Tanaman Cabai melalui Irigasi Tetes
Authors: Susila Anas D , Ketty Suketi  , Mathias Pratama  
Published: January 2024

Fertigasi melalui irigasi tetes merupakan teknologi adaptasi dalam menghadapi perubahan iklim. Penanaman cabai menggunakan irigasi tetes di lahan kering memerlukan jadwal penyiraman yang tepat. Penelitian bertujuan untuk mengevaluasi metode penyiraman berdasarkan sensor kelembaban tanah dan nilai evapotranspirasi pada penanaman cabai menggunakan irigasi tetes. Penelitian dilakukan di Lahan Percobaan Cikarawang, IPB University, Bogor, mulai Juli hingga September 2022. Cabai verietas Imola ditanam pada lahan dengan kandungan P-tersedia 19.6 ppm (sedang) dan K-tersedia 84.64 ppm (tinggi) (Mechlih-1), 1.45 C Organik, dan pH 6.85. Perlakuan jadwal penyiraman disusun dalam Rancangan Acak Kelompok dengan perlakuan 1xETc, 2xETc (1.2 kali nilai evapotranspirasi tanpa sensor), 2xETc-S (menggunakan sensor kelembaban tanah) dengan 6 ulangan. Hasil penelitian menunjukkan bahwa semua metode penyiraman dapat digunakan untuk mendukung produksi cabai dengan produktivitas rata-rata 8.825 - 10.797 ton ha-1. Secara umum, perlakuan 2xETc-S menghasilkan bobot buah per bedengan tertinggi dibandingkan perlakuan 1xETc dan 2xETc. Bobot buah cabai tidak layak pasar per bedeng tertinggi terdapat pada perlakuan 2xETc. Untuk implementasi lapangan komersial, perlu mempertimbangkan jumlah sensor, ambang batas kelembaban, dan volume penyiraman untuk memaksimalkan kualitas dan produktivitas.
Keywords: evapotranspirasi, jadwal irigasi, lahan kering, sensor kelembaban tanah
Karakterisasi Taoge dan Potensinya pada Galur-Galur Kacang Hijau IPB
Authors: Ishmatalhaq Zannuba , Siti Marwiyah  , Surjono Hadi Sutjahjo  , Desta Wirnas  
Published: January 2024

Taoge atau kecambah merupakan salah satu jenis sayuran yang banyak dikonsumsi masyarakat Indonesia. Taoge salah satunya dihasilkan dari perkecambahan biji kacang hijau (Vigna radiata L.). Taoge mengandung beberapa zat yang berperan sebagai antioksidan di antaranya fitosterol, fenol, flavonoid, vitamin E, niasin, vitamin C, dan mineral. Taoge memiliki potensi produksi yang cukup menjanjikan mengingat banyaknya manfaat yang terkandung dalam sayuran tersebut. Penelitian ini bertujuan mendapatkan informasi karakter biji dan taoge, pendugaan potensi taoge serta mendapatkan galur potensial untuk dikembangkan menjadi taoge pada galur-galur kacang hijau IPB. Penelitian dilaksanakan pada bulan Februari sampai Maret 2023 di Laboratorium Pemuliaan Tanaman, Departemen Agronomi dan Hortikultura. Materi genetik kacang hijau terdiri atas 17 galur kacang hijau IPB dan dua varietas nasional (Vima 1 dan Vimil 1) sebagai pembanding. Pengujian kecambah dilaksanakan berdasarkan rancangan kelompok lengkap teracak (RKLT) yaitu 19 genotipe dengan tiga ulangan. Penelitian menggunakan 30 butir kacang hijau per satuan percobaan. Pengamatan dilakukan terhadap karakter kuantitatif dan kualitatif taoge dan biji galur kacang hijau IPB. Hasil penelitian menunjukkan pengaruh nyata genotipe terhadap karakter panjang taoge, bobot satuan taoge, bobot total taoge dan bobot 100 butir. Galur kacang hijau IPB yang memiliki potensi unggul produksi taoge adalah F7-VR10/V1-49, F7-Lom2/129-37, F7-VR10/V1-27, F7-Lom2/129-34, F7-VR10/V1-13, F7-Lom2/129-49, dan F7-VR10/V1-29.
Kata kunci: biji, kecambah, kualitatif, kuantitatif, potensi hasil, produksi
Pemeriksaan Uji Kenormalan dengan Kolmogorov-Smirnov, Anderson-Darling dan Shapiro-Wilk
Authors: Ahadi Giatma Dwijuna , Zain Neni Nur Laili Ersela 
Published: January 2024

Distribusi normal adalah asumsi penting untuk banyak metode statistik. Pengujian normalitas biasanya menggunakan beberapa metode seperti kolmogorov-smirnov, Anderson-Darling dan tes Shapiro-Wilk. Pengujian simulasi dengan menghasilkan data dari distribusi normal, distribusi- t dan distribusi eksponensial. Pada data bangkitan diperoleh bahwa metode Shapiro-Wilk lebih baik dari metode lainnya, sedangkan pada sampel besar didapatkan bahwa metode Anderson-Darling lebih baik dari metode yang lainnya. Data bangkitan distribusi menunjukkan nilai kumulatif menolak mendekati 100% yang artinya data tidak berdistribusi normal. Sedangkan pada data bangkitan karena nilai derajat bebas ( semakin konsisten terhadap maka menyebabkan distribusi data mendekati normal dan diperoleh hasil bahwa nilai kumulatif yang paling konsisten adalah metode Anderson-Darling. Selanjutnya pada bangkitan data menghasilkan nilai kumulatif menolak mendekati 100% dengan metode yang paling konsisten adalah Kolmogorov-Smirnov. Sehingga dapat diketahui bahwa pemilihan uji normalitas sangat bergantung pada jumlah sampel dan sebaran datanya.
Students' Critical Thinking Ability in Solving Story Problems of Three-Variable Linear Equation System
Authors: Nurqodri Zahrani , Setyaningsih Rini 
Published: January 2024

This study aims to describe how the critical thinking process of students in solving math problems in the form of story problems of the Three-Variable Linear Equation System (SPLTV). This type of research is descriptive and uses qualitative methods. The subjects in this study were 6 students of class X 5 SMA Batik 1 Surakarta with high, medium, and low categories. Data collection techniques used tests and interviews, which have been declared valid by validators. Indicators of students' critical thinking abilities in research include clarification, assessment, strategy and inference. The results of this study are high category students can fulfill all indicators of critical thinking aspects, namely clarification, assessment, strategies, and inference. Medium category students are only able to fulfill three indicators, namely clarification, assessment, and strategies or only two indicators, namely clarification, and assessment. Low category students are only able to fulfill one critical thinking indicator, namely clarification, while other subjects cannot fulfill any critical thinking indicators.
Keywords: critical thinking, math story problems, SPLTV.
The Relation Between Mathematics Philosophy And Culture-Based Learning Model
Authors: Hasibuan Eka Khairani , Dewi Izwita 
Published: January 2024

The aim of this study is to study the correlation of mathematical philosophy with cultural-based learning models. The method of research used is the method of library research, i.e. conducting studies related to mathematical philosophy, philosophical mathematics learning, culture-based mathematic learning, the connection of mathematically philosopher with ethnomatematics, the relationship of mathematic philosophies with cultural-based learning models. The results of the research have been obtained that the philosofy of maths, the model of learning based on culture, and ethnomathematics have close connections in the context of understanding and teaching of Mathematics. Mathematical philosophy deals with the foundations of mathematical epistemology and ontology, while a culture-based learning model emphasizes the integration of values and cultural contexts in mathematics learning. Ethnomatematics refers to the study of mathematical ways of thinking in a particular culture. By understanding the cultures, traditions, and world views of a particular society, ethnomathematics can help develop more culturally relevant and meaningful learning models. Therefore, the interrelationship between mathematical philosophy, culture-based learning models, and ethnomathematics can create a more holistic and contextual approach to mathematics learning.
Keywords: Mathematical Philosophy, Cultural Based Learning Model, Ethnomathematics
Valuation of the effectiveness of physical rehabilitation for postural disorders in the adolescent pupils age
Authors: Kotsur Nadiia , Tovkun Lidiia , Homonai Ihor 
Published: January 2024

In the article, based on the analysis and generalization of literary sources, reveals the state of development of the problem of prevention and correction of postural disorders in adolescent pupils. Modern approaches to the prevention and correction of postural disorders in schoolchildren in the conditions of educational institutions by means of physical rehabilitation are analyzed in it. The purpose of the scientific article is to study the influence of health-improving means of physical rehabilitation in the correction of postural disorders in schoolchildren of adolescent age. According to the purpose of the research, the types of postural disorders in adolescents were determined and a physical rehabilitation program is developed, which included a set of special exercises for forming and correcting posture during physical culture and strengthening them at home.
The results of the conducted research testify to the effectiveness of the rehabilitation program in correcting postural disorders in adolescent pupils and the feasibility of its implementation in the educational process of secondary education institutions.
Infusion of individual style into the professional activity of a trainer
Authors: Maliar Eduard , Maliar Nelya , Gakh Roman , Bezpalova Natalia 
Published: January 2024

This work analyzes the infusion of individual style into professional coaching activity, which consists of two mutually related components: directly sports activity (development of rocine bones, training and thorough This is a technical and tactical activity, the participation of both sides and the pedagogical activity of the coach as a mentor , teacher, teacher (influence on the formation of character, valuable attitudes, formation of specialness). In addition, the use of motor physical exercises should be considered only as material for the activity-practical dialogue of the coach and the athlete and act as a means of self-realization of the individual with the coach's main attention being directed to the development of the individual, as a single social and natural, spiritual and physical, and not only to the formation of the organism , as a system of impersonal physiological and biological mechanisms.
In the process of research, an analysis of the content of coaching activities, which is carried out within the framework of physical culture and sports as an element of human culture as a whole; the main professional qualities and character traits of a coach are determined for obtaining a positive result when developing an individual style in one's professional activity (kindness and attentiveness to students, sociability, justice, honesty, principledness, hard work, sacrifice, professional talent, high morality, broad outlook and erudition, spiritual culture, optimism, emotional stability, competence, professionalism, endurance, perseverance, compassion, patience and kindness, creativity, intuition, sense of humor and others).
Coordination abilities of female cadets in higher education institutions of the Ministry of Internal Affairs of Ukraine
Authors: Torlo Olena , Chervonoshapka Maryna , Hnyp Ihor , Kotov Serhii , Muzyka Bohdan , Moroz Taras 
Published: January 2024

Significant number of women want to study in the higher education institutions and work in the system of the Ministry of Internal Affairs of Ukraine. The training of female cadets with a high level of development of motor skills is an important task in higher education instituti ons of the Ministry of Internal Affairs of Ukraine.
The level of coordination abilities is an important component in the structure of the overall physical fitness of female cadets. The aim of our work was to study the indicators of coordination abilities of female cadets at the initial stage of training. In the course of our work we studied the coordination readiness of 60 female cadets: the level of static balance, the ability to coordinate hand movements, the ability to general coordinate body movements, the ability to differentiate spatial and temporal parameters of movements, the ability to orientate in space. In the process of work, we used tests that are recommended in scientific and methodical literature.
We found that female cadets at the beginning of their studies do not have a sufficiently high level of coordination abilities. In tests of a jumping and running nature, in which speed-power abilities are manifested, women have low results. Higher results are observed in tests for assessing the ability to balance, coordination of hand movements and orientation in space. Therefore, paying attention to the coordination training of female cadets is relevant.