bluuebunny/crossref_metadata_2025_split huggingface dataset:
Effective mission-oriented research: A new framework for systemic research impact assessment
Authors: Pfeifer Lena , Helming Katharina 
Published: February 2024

Abstract
Mission-oriented research combines a wide array of natural and social science disciplines to offer solutions for complex and multi-dimensional challenges such as climate change, loss of biodiversity, and scarcity of natural resources. The utilization of the outputs of mission-oriented research aims for changes in behavior, policy and practice resulting in real world impacts. Systematically assessing such research impacts and impact-generating processes is novel and offers great potential to plan for impactful research. This article develops a framework for systemic research impact assessment (RIA) on the basis of a literature review taking natural resource management (NRM) research as an example. The review compiles and analyzes 70 relevant RIA approaches. The resulting framework combines four components for improving societal impacts (1) an integrated component enabling reflection of impacts on all sustainability dimensions, (2) a missions component orienting toward societal goals to ensure societal relevance, (3) an inclusive component enabling wide participation to ensure legitimacy of research and its impact, and (4) a strategic component to choose appropriate assessment scales and time dimensions to ensure effectiveness. We provide suitable examples for the framework and we conclude with a call for an increased use of systemic and formative RIA that incorporate participatory strategies for research priority setting as well as socially deliberated target systems (e.g. SDGs), to plan for impactful mission-oriented research.
Developmental changes in brain function linked with addiction-like social media use two years later
Authors: Flannery Jessica S , Burnell Kaitlyn , Kwon Seh-Joo , Jorgensen Nathan A , Prinstein Mitchell J , Lindquist Kristen A , Telzer Eva H 
Published: February 2024

Abstract
Addiction-like social media use (ASMU) is widely reported among adolescents and is associated with depression and other negative health outcomes. We aimed to identify developmental trajectories of neural social feedback processing that are linked to higher levels of ASMU in later adolescence. Within a longitudinal design, 103 adolescents completed a social incentive delay task during 1–3 fMRI scans (6–9th grade), and a 4th self-report assessment of ASMU and depressive symptoms ∼2 years later (10–11th grade). We assessed ASMU effects on brain responsivity to positive social feedback across puberty and relationships between brain responsivity development, ASMU symptoms, and depressive symptoms while considering gender effects. Findings demonstrate decreasing responsivity, across puberty, in the ventral media prefrontal cortex, medial prefrontal cortex, posterior cingulate cortex, and right inferior frontal gyrus associated with higher ASMU symptoms over 2 years later. Significant moderated mediation models suggest that these pubertal decreases in brain responsivity are associated with increased ASMU symptoms which, among adolescent girls (but not boys), is in turn associated with increased depressive symptoms. Results suggest initial hyperresponsivity to positive social feedback, before puberty onset, and decreases in this response across development, may be risk factors for ASMU in later adolescence.
Zygomaticus activation through facial neuromuscular electrical stimulation (fNMES) induces happiness perception in ambiguous facial expressions and affects neural correlates of face processing
Authors: Efthimiou Themis Nikolas , Baker Joshua , Clarke Alasdair , Elsenaar Arthur , Mehu Marc , Korb Sebastian 
Published: February 2024

Abstract
The role of facial feedback in facial emotion recognition remains controversial, partly due to limitations of the existing methods to manipulate the activation of facial muscles, such as voluntary posing of facial expressions or holding a pen in the mouth. These procedures are indeed limited in their control over which muscles are (de)activated when and to what degree. To overcome these limitations and investigate in a more controlled way if facial emotion recognition is modulated by one’s facial muscle activity, we used computer-controlled facial neuromuscular electrical stimulation (fNMES). In a pre-registered EEG experiment, ambiguous facial expressions were categorised as happy or sad by 47 participants. In half of the trials, weak smiling was induced through fNMES delivered to the bilateral Zygomaticus Major muscle for 500 ms. The likelihood of categorising ambiguous facial expressions as happy was significantly increased with fNMES, as shown with frequentist and Bayesian linear mixed models. Further, fNMES resulted in a reduction of P1, N170 and LPP amplitudes. These findings suggest that fNMES-induced facial feedback can bias facial emotion recognition and modulate the neural correlates of face processing. We conclude that fNMES has potential as a tool for studying the effects of facial feedback.
Efficacy and safety of short- vs. standard-course antibiotics for culture-negative neonatal sepsis: a systematic review and meta-analysis
Authors: Devi Risha , Priyadarshi Mayank , Singh Poonam , Chaurasia Suman , Basu Sriparna 
Published: February 2024

Abstract

Objectives
To conduct a systematic review and meta-analysis of evidence from randomized controlled trials (RCTs) comparing a short course of antibiotics (2–4 days), to a standard course (5–7 days), for the treatment of culture-negative neonatal sepsis.

Methods
Relevant databases were searched for RCTs comparing short- vs. standard-course of antibiotics for culture-negative sepsis. The primary outcomes were mortality and treatment failure, defined as the reappearance of clinical signs suggestive of sepsis within 7 days of stoppage of antibiotics. Secondary outcomes included neurological impairment, duration of hospital stay, need for oxygen, respiratory support and double-volume exchange transfusion (DVET).

Results
Seven RCTs were included in the review with 729 neonates &gt;30 weeks gestational age at birth. No mortality occurred in either of the groups (2 studies; 276 neonates). Treatment failure rates were similar in the short- and standard-course antibiotic groups [7 studies; 729 neonates; risk ratio (RR) = 1.01; 95% confidence interval (CI), 0.55 to 1.86; very low certainty]. The short course of antibiotics resulted in a shorter hospital stay [3 studies; 293 neonates; mean difference (MD), −2.46 days; 95% CI, −3.16 to −1.75]. There was no difference in the need for oxygen supplementation (2 studies; 258 neonates; RR, 1.40; 95% CI, 0.40 to 4.91), any respiratory support (2 studies; 258 neonates; RR, 1.04; 95% CI, 0.92 to 1.17) or DVET (2 studies; 258 neonates; RR, 1.29; 95% CI, 0.56 to 2.95).

Conclusion
Very-low certainty evidence suggests that a short antibiotic course, compared to a standard course, does not affect treatment failure rates in culture-negative neonatal sepsis. There is a need for well-designed RCTs powered enough to assess critical outcomes such as mortality and neurological sequelae to generate stronger evidence and inform guidelines.

PROSPERO registration number
CRD42023437199
SETD3 regulates endoderm differentiation of mouse embryonic stem cells through canonical Wnt signaling pathway
Authors: Alganatay Ceren , Balbasi Emre , Tuncbag Nurcan , Sezginmert Dersu , Terzi Cizmecioglu Nihal 
Published: February 2024

AbstractWith self‐renewal and pluripotency features, embryonic stem cells (ESCs) provide an invaluable tool to investigate early cell fate decisions. Pluripotency exit and lineage commitment depend on precise regulation of gene expression that requires coordination between transcription (TF) and chromatin factors in response to various signaling pathways. SET domain‐containing 3 (SETD3) is a methyltransferase that can modify histones in the nucleus and actin in the cytoplasm. Through an shRNA screen, we previously identified SETD3 as an important factor in the meso/endodermal lineage commitment of mouse ESCs (mESC). In this study, we identified SETD3‐dependent transcriptomic changes during endoderm differentiation of mESCs using time‐course RNA‐seq analysis. We found that SETD3 is involved in the timely activation of the endoderm‐related gene network. The canonical Wnt signaling pathway was one of the markedly altered signaling pathways in the absence of SETD3. The assessment of Wnt transcriptional activity revealed a significant reduction in Setd3‐deleted (setd3∆) mESCs coincident with a decrease in the nuclear pool of the key TF β‐catenin level, though no change was observed in its mRNA or total protein level. Furthermore, a proximity ligation assay (PLA) found an interaction between SETD3 and β‐catenin. We were able to rescue the differentiation defect by stably re‐expressing SETD3 or activating the canonical Wnt signaling pathway by changing mESC culture conditions. Our results suggest that alterations in the canonical Wnt pathway activity and subcellular localization of β‐catenin might contribute to the endoderm differentiation defect of setd3∆ mESCs.
Epidermal ET‐1 signal induces activation of resting hair follicles by upregulating the PI3K/AKT pathway in the dermis
Authors: Gao Ying , Fan Zhimeng , Xiao Xing , Kong Deqiang , Han Jimin , Chu Weiwei 
Published: February 2024

AbstractThe prevalence of alopecia has increased recently. Hair loss is often accompanied by the resting phase of hair follicles (HFs). Dermal papilla (DP) plays a crucial role in HF development, growth, and regeneration. Activating DP can revive resting HFs. Augmenting WNT/β‐catenin signaling stimulates HF growth. However, the factors responsible for activating resting HFs effectively are unclear. In this study, we investigated epidermal cytokines that can activate resting HFs effectively. We overexpressed β‐catenin in both in vivo and in vitro models to observe its effects on resting HFs. Then, we screened potential epidermal cytokines from GEO DATASETs and assessed their functions using mice models and skin‐derived precursors (SKPs). Finally, we explored the molecular mechanism underlying the action of the identified cytokine. The results showed that activation of WNT/β‐catenin in the epidermis prompted telogen–anagen transition. Keratinocytes infected with Ctnnb1‐overexpressing lentivirus enhanced SKP expansion. Subsequently, we identified endothelin 1 (ET‐1) expressed higher in hair‐growing epidermis and induced the proliferation of DP cells and activates telogen‐phase HFs in vivo. Moreover, ET‐1 promotes the proliferation and stemness of SKPs. Western blot analysis and in vivo experiments revealed that ET‐1 induces the transition from telogen‐to‐anagen phase by upregulating the PI3K/AKT pathway. These findings highlight the potential of ET‐1 as a promising cytokine for HF activation and the treatment of hair loss.
Predicting Medical Student Performance With a Situational Judgment Test in Admissions
Authors: Ballejos Marlene P. , Cestone Christina , Copeland H. Liesel , Dunleavy Dana M. , Geiger Thomas , Patel Dimple 
Published: February 2024

Abstract

Purpose
To explore correlations between AAMC situational judgment test (SJT) scores, other admissions data, and learners’ medical school performance.

Method
First- and second-year medical students from 8 U.S. MD-granting medical schools completed a prototype version of the AAMC SJT in 2017. Outcomes included research-only faculty ratings of student performance, final course grades, and faculty evaluations of student performance, 2017–2018 and 2018–2019 academic years. Bivariate correlations were used to investigate the relationship between SJT scores and student performance outcomes and hierarchical regressions to investigate whether SJT scores provided incremental validity over MCAT total scores and cumulative undergraduate grade point averages (UGPAs) for predicting student performance outcomes.

Results
In general, there were small positive correlations with research-only faculty ratings from the first year of medical school, with the highest for social skills/service orientation (r
corrected = .33, P < .05). Correlations were higher, with the highest for social skills/service orientation and cultural competence (r
corrected = .33 and .36, respectively, P < .05) in the second year in medical school. SJT scores improved prediction of research-only faculty ratings over MCAT total scores and UGPAs for reliability and dependability/capacity for improvement, cultural competence, social skills/service orientation, and the overall composite score in the first year and for resilience and adaptability, social skills/service orientation, cultural competence, and the overall composite score in the second year. SJT scores demonstrated small correlations with course grades (r
sample-weighted = .10, P = ns) and faculty evaluations related to professionalism skills (r
sample-weighted = .14, P < .05); however, MCAT total scores explained most of the variance associated with course outcomes.

Conclusions
These studies provide initial evidence that SJT scores may add value to the medical school admissions process because scores were related to faculty ratings of professional behaviors and provided unique information relative to MCAT scores and UGPAs.
Examining ChatGPT Performance on USMLE Sample Items and Implications for Assessment
Authors: Yaneva Victoria , Baldwin Peter , Jurich Daniel P. , Swygert Kimberly , Clauser Brian E. 
Published: February 2024

Abstract

Purpose
In late 2022 and early 2023, reports that ChatGPT could pass the United States Medical Licensing Examination (USMLE) generated considerable excitement, and media response suggested ChatGPT has credible medical knowledge. This report analyzes the extent to which an artificial intelligence (AI) agent’s performance on these sample items can generalize to performance on an actual USMLE examination and an illustration is given using ChatGPT.

Method
As with earlier investigations, analyses were based on publicly available USMLE sample items. Each item was submitted to ChatGPT (version 3.5) 3 times to evaluate stability. Responses were scored following rules that match operational practice, and a preliminary analysis explored the characteristics of items that ChatGPT answered correctly. The study was conducted between February and March 2023.

Results
For the full sample of items, ChatGPT scored above 60% correct except for one replication for Step 3. Response success varied across replications for 76 items (20%). There was a modest correspondence with item difficulty wherein ChatGPT was more likely to respond correctly to items found easier by examinees. ChatGPT performed significantly worse (P < .001) on items relating to practice-based learning.

Conclusions
Achieving 60% accuracy is an approximate indicator of meeting the passing standard, requiring statistical adjustments for comparison. Hence, this assessment can only suggest consistency with the passing standards for Steps 1 and 2 Clinical Knowledge, with further limitations in extrapolating this inference to Step 3. These limitations are due to variances in item difficulty and exclusion of the simulation component of Step 3 from the evaluation—limitations that would apply to any AI system evaluated on the Step 3 sample items. It is crucial to note that responses from large language models exhibit notable variations when faced with repeated inquiries, underscoring the need for expert validation to ensure their utility as a learning tool.
A Comparison of Montreal Cognitive Assessment Scores among Individuals with Normal Hearing and Cochlear Implants
Authors: Graves Emily A. , Sajjadi Autefeh , Hughes Michelle L. 
Published: February 2024

Objectives:
The Montreal Cognitive Assessment (MoCA) is a cognitive screening tool that has 4 of 10 test items heavily dependent on auditory input, potentially leaving hearing-impaired (HI) individuals at a disadvantage. Previous work found that HI individuals scored lower than normal-hearing (NH) individuals on the MoCA, potentially attributed to the degraded auditory signals negatively impacting the ability to commit auditory information to memory. However, there is no research comparing how cochlear implant (CI) recipients perform on the MoCA relative to NH and HI individuals. This study aimed to (1) examine the effect of implementing three different hearing-adjusted scoring methods for a group of age-matched CI recipients and NH individuals, (2) determine if there is a difference between the two groups in overall scores and hearing-adjusted scores, and (3) compare scores across our CI and NH data to the published HI data for all scoring methods. We hypothesized that (1) scores for CI recipients would improve with implementation of the hearing-adjusted scoring methods over the original method, (2) CI recipients would score lower than NH participants for both original and adjusted scoring methods, and (3) the difference in scores between NH and CI listeners for both adjusted and unadjusted scores would be greater than that reported in the literature between NH and HI individuals due to the greater severity of hearing loss and relatively poor spectral resolution of CIs.

Design:
A total of 94 adults with CIs and 105 adults with NH were initially enrolled. After age-matching the two groups and excluding those who self-identified as NH but failed a hearing screening, a total of 75 CI participants (mean age 61.2 y) and 74 NH participants (mean age 58.8 y) were administered the MoCA. Scores were compared between the NH and CI groups, as well as to published HI data, using the original MoCA scoring method and three alternative scoring methods that excluded various auditory-dependent test items.

Results:
MoCA scores improved for all groups when two of the three alternative scoring methods were used, with no significant interaction between scoring method and group. Scores for CI recipients were significantly poorer than those for age-matched NH participants for all scoring methods. CI recipients scored better than the published data for HI individuals; however, the HI group was not age matched to the CI and NH groups.

Conclusions:
MoCA scores are only partly affected by the potentially greater cognitive processing required to interpret degraded auditory signals. Even with the removal of the auditory-dependent items, CI recipients still did not perform as well as the age-matched NH group. Importantly, removing auditory-dependent items significantly and fundamentally alters the test, thereby reducing its sensitivity. This has important limitations for administration and interpretation of the MoCA for people with hearing loss.
Cardiovascular complications of rheumatoid arthritis
Authors: Park Elizabeth , Bathon Joan 
Published: February 2024

Purpose of review
Rheumatoid arthritis (RA) patients remain at higher cardiovascular (CV) risk compared to non-RA patients, driven by accelerated atherosclerosis, leading to plaque rupture and acute CV events (CVE), including heart failure (HF). It has been hypothesized that chronic inflammation is the main driving force behind such outcomes. We summarize the current evidence supporting this hypothesis, focusing on arterial disease and myocardial disease.

Recent findings
RA patients demonstrate higher prevalence of subclinical atherosclerosis (high risk plaque and arterial inflammation) compared to non-RA patients, with RA disease activity correlating independently with CVE and death. Nonischemic HF with preserved ejection fraction (HFpEF) is more common in RA compared to non-RA, with subclinical myocardial structural and functional alterations also more prevalent in RA. HFpEF and myocardial remodeling and dysfunction bear a strong and independent association with inflammatory correlates.

Summary
All of this suggests that inflammation contributes to enhanced risk of CVE in RA. A more accurate and specific CV risk stratification tool for RA, incorporating biomarkers or imaging, is needed. Likewise, more prospective studies outlining the trajectory from preclinical to clinical HF, incorporating biomarkers and imaging, are also needed.
Epidemiology of Schmorl’s Node in the Thoracic Spine
Authors: Que Yongsheng , Zhang Miaoru , Luo Xiaozhen , Xia Xing , Huang Yuantao , Wang Ce , Chen Min , Xu Junqing 
Published: February 2024

Study Design.
Retrospective observational study.

Objective.
To describe the epidemiology of Schmorl’s nodes (SN) of primarily developmental cause (SNd) and SN of primarily acquired cause (SNa) separately in the thoracic spine in subjects aged 35-90 years old.

Summary of Background Data.
The epidemiology of SN and its relationship with age and gender remain controversial. Based on a pathophysiological hypothesis and the different morphological characteristics, two subtypes of SN may exist and should be considered separately.

Patients and Methods.
Chest CT scans of subjects who came to our institution for health check aged 35-90 years old were retrospectively reviewed. Presence or absence of SN was recorded for each thoracic vertebra. The SNs were further classified into SNd and SNa. The prevalence, location and relationship with age, gender and bone mineral density (BMD) were evaluated separately for the two subtypes.

Results.
Of the 848 subjects (407 female, mean age, 53±12.2 y) included, 15.7% had SNs. Of the 303 SNs, 49.2% were SNd and 48.5% were SNa. Aging increased the prevalence of SNa while it was not related to the prevalence of SNd. Males had significantly more SNd than females (11.3% vs 4.7%, P<0.001), while the prevalence of SNa was not different between the two genders (10.2% vs 9.1%, P=0.666). A similar distribution of SNd and SNa among thoracic vertebral levels was appreciated, with T9 most frequently involved. Subjects with SNa had lower lumbar BMD than controls (P=0.006), while no significant difference in BMD was found between subjects with SNd and controls (P=0.166).

Conclusions.
The clinical characteristics of SN differ based on the developmental and acquired subtype, including the relationship with age, gender and BMD. The subtypes may be considered as distinct clinical entities as a result.
Review of Fractional Nonablative Lasers for the Treatment of Dermatologic Conditions in Darker Skin Phototypes
Authors: Aggarwal Ishita , Rossi Marcus , Puyana Carolina , Tsoukas Maria 
Published: February 2024

BACKGROUND
Fractional nonablative lasers (NAFLs) have demonstrated efficacy and safety for treating dermatologic conditions in patients with darker skin phototypes. Nonablative lasers are preferred in darker skin tones due to lower risk of postinflammatory hyperpigmentation.

OBJECTIVE
This review aims to identify the ideal laser options and parameters for treating common dermatologic conditions in patients with skin types IV-VI.

MATERIALS AND METHODS
A comprehensive literature search was conducted on PubMed in May 2023. Of 1,065 articles were identified, and 40 articles met the inclusion criteria. The studies were classified based on design, dermatologic condition, and skin phototype of patients, and assigned levels of evidence according to the Modified Criteria of the Oxford Center of Evidence Based Medicine.

RESULTS
Strong level 1 evidence supports the treatment of melasma and atrophic scars using NAFL. Moderate level 2 evidence was found for using NAFL in acne vulgaris, striae, and skin rejuvenation; 45% of the studies examined skin types III-IV, 20% III-V, 7.5% II-IV, 5% II-V, 5% IV alone, and 2.5% I-IV.

CONCLUSION
Further research is needed to determine the optimal treatment modalities and parameters for skin types V and VI. Appropriate device selection and conservative treatment settings are crucial for optimizing outcomes and minimizing adverse events.