bluuebunny/crossref_metadata_2025_split huggingface dataset:
Integrating MADM Methods and Genetic Algorithm for Exploring Interior Optimizing Design Strategies to Decrease the Risk of Nosocomial Infection in Dental Clinic
Authors: Wang Ge , Tan Shuting , Cao Yina , Wu Chenyu , Xiong Lei 
Published: October 2023

Abstract
Nosocomial Infections (NIs) are a major global public health problem, and their prevention and control are becoming increasingly challenging as their mechanisms become more complex. With a growing elderly population, an escalating number of patients are becoming vulnerable, and the higher incidence of severe infectious diseases has resulted in a surge in the cost of NI prevention and control. Facing the severity of hospital-acquired infections and preventing the occurrence of other potential widespread public health crises necessitates a complete redesign in our approach to effectively minimise such infections in dental hospitals. Therefore, the primary objective should be to mitigate the incidence of hospital-acquired infections by investigating the best design strategies for the layout of functional areas, the organisation of flow lines, and the decorative aesthetic of the spatial environment of the dental hospital. In this study, we identified spatial planning and design elements aimed at mitigating the risk of nosocomial infections. We constructed a framework for these design elements using exploratory factor analysis (EFA). We validated the complex relationships and priority criteria in the evaluation framework using DANP. Furthermore, we iteratively extrapolated spatial sketches using genetic algorithms, and optimisation was conducted accordingly. The study's key implication is the development of a comprehensive structure that allows decision makers to assess the spatial setting of oral healthcare objectively. They can then map the network of relationships (INRM) based on the results of the performance assessment, assign impact weights (IWs) to each criterion, and optimise spatial scenarios using genetic algorithms. To prevent the wastage of resources resulting from haphazard design, more efficient and scientific resources are invested into the design of dental hospital spaces.
Early Development and Enzyme Activity in Japanese Freshwater Shrimp, Neocaridina denticulata sinensis (Kemp, 1918)
Authors: Pierre Hardin Aaron Jn , Kotani Tomonari , Sasaki Taku , Irabor Arnold Ebuka 
Published: October 2023

Abstract
The present investigation was undertaken with the primary objective of critically evaluating the progression of early developmental stages and concurrent enzymatic activity in the Japanese freshwater shrimp, Neocaridina denticulata sinensis. The scope of the study encompassed a thorough examination of the growth patterns and respective enzyme activity of N. denticulata larvae at distinctive phases, specifically at 15, 30, 45, and 60 days after hatching (DAH). This research turned its focus toward three prominent enzymes: amylase, lipase, and protease, and their respective roles and activity levels in the course of the developmental process. Throughout the duration of the empirical experiment, there was a consistent trajectory of growth documented, devoid of any significant abnormalities that might otherwise mar the data. Consequently, this implies a strong adaptability of N. denticulata to the conditions imposed by the experimental setup. Drawing a comparison between the larval and adult stages, the study found noteworthy parallels in both physical attributes and histological characteristics. This fascinating discovery reveals a certain level of developmental uniformity across the lifespan of this species. Interestingly, the enzyme activity demonstrated a trend of increment with the progression of each growth stage. Among the enzymes studied, Protease registered the highest level of activity, emphasizing its potential crucial role in the development and growth of N. denticulata larvae. However, a certain anomaly was observed in the Lipase activity, which exhibited a dip at specific stages of the larval cycle, only to increase as the larvae aged. This intermittent pattern in lipase activity sparks interest and warrants further investigation to comprehend its implications fully. Overall, the N. denticulata demonstrated a robust growth pattern under the experimental conditions imposed, with enzyme activity showcasing a parallel increment in tandem with the age of the larvae. Despite the findings, the current study has opened doors for future explorations, particularly with a focus on enzyme activity associated with the digestive tract development in the early stages of the development of N. denticulata. This particular aspect remains largely uncharted and promises to significantly augment our understanding in this relatively less explored domain.
Integrated Data Governance, Digital Health, and the Common Data Model (OMOP-CDM)
Authors: Hallinan Christine Mary , Ward Roger , Hart Graeme K , Sullivan Clair , Pratt Nicole , Ng Ashley P , Capurro Daniel , Vegt Anton Van Der , Liaw Teng , Daly Oliver , Luxan Blanca Gallego , Bunker David , Boyle Douglas 
Published: October 2023

Abstract

Adoption of the Observational Medical Outcomes Partnership Common Data Model (OMOP-CDM) internationally and in Australia has enabled the conversion of vast amounts of complex, and heterogeneous electronic medical record (EMR) data into a standardised structured data model. This helps simplify governance processes and facilitates rapid, repeatable cross-institution analysis through shared end-to-end analysis packages without the sharing of raw data.
Combined with pseudonymisation and standardised data quality assessments, the OMOP-CDM provides a powerful model to support ethical real-world ‘big’ data research. The continued adoption of OMOP-CDM, ongoing development efforts, and the emphasis on sound governance practices all contribute to the realisation of OMOP’s utility in unlocking valuable EMR data. These factors collectively support a wide range of applications, from health service operational reporting to diverse clinical, epidemiological, and translational research projects.
Unveiling Environmental Governance Dynamics: Evaluating the Impact of Provincial Government Officials' Corporate Backgrounds on Local Carbon Emissions in China
Authors: Hao Wen jie , li Lulin 
Published: October 2023

Abstract
The nexus between the corporate experiences of local officials and their proclivity for fostering economic growth has long been acknowledged. This study delves into a critical inquiry arising from this connection: does the background in enterprise predispose local officials to prioritize economic development at the expense of green initiatives? Leveraging a dataset spanning 1998 to 2019 and encompassing provincial governors and party secretaries across 30 Chinese provinces, we empirically explore the impact of local officials' corporate careers on regional carbon emissions. Our findings underscore a significant association between the antecedent corporate backgrounds of local officials and heightened carbon emissions within their administered regions. The magnitude of this influence varies, contingent on factors such as the nature of their prior corporate affiliations, promotion incentives, interregional transfers, tenure in office, and the energy resources and economic development context of their jurisdictions. Moreover, our analysis reveals a nuanced dynamic: as the top-down "performance orientation" shifts from an exclusive emphasis on economic development to a dual focus on both economic and environmental considerations, local officials' corporate backgrounds emerge as a mitigating factor, reducing the intensity of carbon emissions in their regions. Further mechanism testing discerns a distinct dual impact of local officials with corporate backgrounds. In the realm of environmental performance, there is a marked reduction in environmental investments within their jurisdiction during their tenure. Simultaneously, within the sphere of economic performance, these officials exhibit a significant upswing in the proliferation of "large-scale industrial enterprises, foreign investment, and public expenditure," emblematic of heightened carbon emissions. This research not only provides insights into the persistent challenge of China's historically elevated carbon emissions from the perspective of local officials but also offers valuable references for government governance structures aiming to achieve the objectives of "dual carbon" targets.
Comprehensive Analysis of the Expression of IGFBPs and its Correlation with Prognosis and Immune in Endometrial Cancer
Authors: Jin Yuxi , Qi Meng , Cai Mingbo , Si Lulu , Fu Hanlin , Liu Yana , Guo Ruixia 
Published: October 2023

Abstract

Endometrial cancer (EC) is one of the most common malignant tumors of the female reproductive tract. Insulin-like growth factor-binding proteins (IGFBPs) as regulators of IGF signaling in cancer are of increasing interest. However, the role of the IGFBP family in EC has not been fully explored. The expression of IGFBPs and their association with clinical prognosis, biological function, mutation status, and immune infiltration in EC patients were investigated using the TCGA, STRING, cBioPortal, TIMER and TCIA databases. The protein levels of the IGFBP family in collected patient samples were further identified by immunohistochemical methods. In patients with EC, IGFBP2 was significantly upregulated, while other IGFBPs were downregulated. The expression levels of IGFBP4 and IGFBP7 in EC decreased with increasing tumor grade and low expression of IGFBP4 was correlated with poor overall survival. The co-expression network and enrichment analysis results showed that IGFBP4 was related to microtubule-based movement, collagen-containing extracellular matrix, and vascular smooth muscle contraction. Moreover, IGFBP2/3/4/7 expression was correlated with tumor mutation burden and the levels of tumor-infiltrating immune cells in EC, and IGFBP7 in particular was significantly associated with immunotherapy response. This study revealed the expression of the IGFBP family in EC patients and showed that IGFBP4 could be a valuable prognostic indicator and that IGFBP7 may be a potential immunotherapeutic target for EC.
ACD856, a Novel Positive Allosteric Modulator of Trk-receptors, Single Ascending Doses in Healthy Subjects: Safety and Pharmacokinetics
Authors: Nilsson Boel , Bylund Johan , Halldin Magnus M , Rother Matthias , Rein-Hedin Erik , Önnestam Kristin , Segerdahl Märta 
Published: October 2023

Abstract
AlzeCure Pharma AB is developing novel positive allosteric modulators of Trk-receptors for treatment of Alzheimer’s disease, depression, other psychiatric conditions and other disorders where cognition is impaired. The first candidate drug ACD855 was, in a single ascending dose study, shown to have a too long elimination half-life in humans for further development. To de-risk the development of the follow-up compound ACD856, an intravenous microdose study was conducted to assess the elimination half-life in plasma prior to conducting ascending oral dose studies. Reported within this article are the results of the phase 0 study with a microdose of ACD856 (0.100 mg), conducted in six healthy male subjects, followed by a Phase I single ascending oral dose study (1–150 mg) in 56 healthy subjects. ACD856 was well tolerated with no treatment emergent, or dose related trends observed for adverse events or other safety assessments. In the microdose study, ACD856 exhibited a bi-exponential plasma decline, low distribution volume, low plasma clearance with a half-life of approximately 20 hours. Orally, ACD856 exhibited rapid absorption, approximately 100% bioavailability and a dose proportional increase in exposure. While the Cmax was lowered and delayed by food intake, the effect on plasma half-life and the overall bioavailability was low. No renal elimination of ACD856 was detected. The pharmacokinetics of ACD856 in humans following a microdose was used to de-risk a long elimination half-life as well as predict oral pharmacokinetics. The prediction proved accurate demonstrating the value of conducting a microdose study prior to ascending dose studies. TRN: NCT05783830 March 24, 2023 (microdose study, retrospectively registered) and NCT05077631 October 14, 2021 (Single ascending dose study).
Distraction from long-term memory in visual search: acquired procedural and template-based memory interfere with contextual cueing after target re-location.
Authors: Seitz Werner , Zinchenko Artyom , Müller Hermann J. , Geyer Thomas 
Published: October 2023

Abstract
Participants can learn to detect search-for target items embedded in repeatedly encountered spatial arrangements of distractor items – the ‘contextual-cueing’ (CC) effect. However, cueing is severely compromised following the re-positioning of the target in an otherwise unchanged distractor arrangement. Previous research demonstrated that this target re-location cost is due to persistent contextual (mis-)guidance of search towards the original, but (after the re-positioning) no longer relevant location in the display array. Given that CC reflects top-down guidance for contextual long-term (LT) memory, this misguidance is an instance of a ‘distraction’ effect that operates from acquired memory, rather than being driven by salient but irrelevant stimuli in the display. While traditional accounts of CC emphasize the acquisition of search-guiding LT-memory ‘templates’ that are specific to particular target-distractor contexts, contextual learning also tunes attentional (oculomotor) scanning routines to the prevailing statistical target-distractor regularities in the display arrangement encountered, yielding a context-unspecific LT ‘proceduralization’ of search. Using reaction-time (RTs) and oculomotor-scanning measures, we confirmed both mechanisms to contribute to initial contextual learning as well as the ‘distraction’ effect produced by re-location of the target to the opposite side of repeated-context displays. We suspect that guidance and misguidance of search by repeated contexts involve two complementary LT mechanisms: procedural optimization of broad, i.e., display-generic, oculomotor scanning routines, and learning of where to expect the target to be located in specific repeated-context displays.
Enhancing the performance, carcass characteristics, diet digestibility, and economic viability of pigs in the growing and finishing phases through aspartic protease supplementation: a comprehensive evaluation
Authors: Cruz Thiago Augusto , Muro Bruno Bracco Donatelli , Lima Eduardo Machado Costa , Moreira Valeria dos Santos , Carvalho Julio Cesar Carrera , Garbossa Cesar Augusto Pospissil , Costa Leandro Batista 
Published: October 2023

Abstract
The objective of this study was to evaluate the performance, carcass characteristics, diet digestibility, blood parameters, salivary cortisol levels, and economic viability of pigs administered aspartic protease during the growing and finishing phases. A total of 130 pigs (age, 63 days ± 1; and average weight, 25.56 ± 0.037 kg) were housed in pens in a randomized block design (initial weight and gender). Five treatment protocols were developed and nine replications per treatment were performed. The experimental diets were positive control (PC), according to the recommendations of Rostagno et al. (2017), with a 5.0% reduction in protein and amino acid requirements; negative control (NC), according to the recommendations of Rostagno et al. (2017), with a 7.5% reduction in protein and amino acid requirements; NC + 100 g/ton of aspartic protease (NC100); NC + 150 g/ton of Aspartic protease (NC150); and NC + 200 g/ton of another protease (NC200). The inclusion of protease, independent of the source and amount, increased the daily weight gain (P < 0.05) of animals compared to treatment with the controls, improved feed conversion (P < 0.05) in some phases, and improved diet digestibility (P < 0.05) compared to the PC. Treatment with NC150 and NC200 resulted in greater carcass weights than treatment with the PC. NC100 led to a greater carcass yield than PC, and NC150 resulted in a greater loin eye area than PC. No differences (P > 0.05) in the blood parameters or salivary cortisol levels were found among the treatment groups. Regarding economic viability, the use of protease increased the profitability of production, with NC150 leading to the best results. Thus, the use of aspartic proteases is recommended to improve performance and effectively facilitate pork production.
Analysis of Bilingual Text in Pakistani Advertisements: A Sociolinguistics Study
Authors: Nusrat Muhammad , Ghulam Kishwar 
Published: October 2023

Abstract
This study based on sociolinguistics aspects on advertisements and these advertisements containing bilingual text and diversity of human life governed through advertisements in which all cultural life portrayed by advertisers and designer of these companies design the advertisements according to regional culture as this research based on the bilingual text on Pakistani advertisements and according to Pakistani culture the most common used language is URDU which analyzed in this research along with commonly used international language ENGLISH. This study revealed that linguistics and semiotics on advertisements according to Pakistani culture and this research is based on the qualitative design which explored cross-cultural aspects based on Roland Barthes’s theory. These ads become a source of target audiences of that culture and bilingual text on advertisements became the source of the conversation thus promoting products, and constructing identity in this diversity occurred through bilingual advertisements like Banks, companies’ identity, beauty products, food and clothing brands, medicine companies remained the research study.
Guide for Aquifer Recharge Through Deep Injection Wells in Karst Environments: Case Study Los Elizondo Gallery, Mexico
Authors: ahuja gerardo augusto montemayor 
Published: October 2023

Abstract

The challenges posed by the various factors that affect the loss of surface and underground aquifers worldwide, specifically in Mexico, are increasingly severe. This has forced scientists and technicians to look for alternatives to conserve, sustain, and ensure the sustainability of liquid deposits, whether surface or underground in nature. Based on the above, it was proposed to evaluate the technical and technological feasibility of constructing a well for the artificial injection of water into the subsoil in the Los Elizondo Gallery in the Huajuco area. The objective was to provide a technical and technological guide for the planning, design, and development of groundwater conservation by deep injection. The methodology corresponded to a feasible project, in which the procedures for the construction of the artificial water injection well to underground causes were followed. The technical and technological feasibility of the construction of the well was evaluated, including the examination of the geological and hydrological conditions of the area, as well as the available technologies and materials that can be used to build the well. The execution of the project led to the determination that the construction of a well for the artificial injection of water into the subsoil is technically and technologically feasible in the area of the Los Elizondo Gallery. Once the appropriate procedures were applied, the Guide for aquifer recharge through deep injection wells in karst environments was developed: a case study Los Elizondo Gallery, Mexico.
Enabling biocontained plant virus transmission studies through establishment of axenic whitefly (Bemisia tabaci) colony on plant tissue culture
Authors: Thompson Natalie , Krum David , Chen Yun-Ru , Torres Mariela , Trauger Marena , Strike Dalton , Weston Zachary , Polston Jane , Curtis Wayne 
Published: October 2023

Abstract
A colony of axenic ‘sweet potato’ whiteflies (i.e., free from culturable microorganisms) was established on tissue-cultured plants and was used to demonstrate in vitro begomovirus transmission. A co-culture system based on non-viral host cabbage (Brassica oleracea) provides for efficient maintenance of a whitefly (Bemisia tabaci) colony. The recovery of emerging whiteflies through coupled tissue culture vessels to new axenic plants allows robust subculturing and facilitates the production of hundreds of whitefly adults per month in a 1.1 L tissue culture vessel. This novel ‘communal axenic’ plant-insect-virus (aP-I-V) protocol provides high-level biocontainment to allow for work with genetically modified viruses. Versatility is illustrated by achieving whitefly proliferation on more than a dozen plant species as well as methods for in vitro testing of whitefly preference for different plants – although there were large differences in whitefly accumulation and ease of host use. Although initial colony establishment was achieved with surface sterilization of detached whitefly eggs on vegetatively propagated sweet potato (Ipomoea batatas), a much more reliable approach is described based on non-axenic whitefly egg-lay onto axenic phototrophically tissue-cultured plants, followed by surface sterilization of the pedicel-attached eggs. Axenic whitefly adults were able to acquire and transmit tomato mottle virus (ToMoV) (Genus: begomovirus) from Nicotiana benthamiana tissue cultured material. This indicated the absence of a role for culturable gut microorganisms in the transmission of this begomovirus. Acquisition occurred from tissue-cultured plants initially inoculated with ToMoV via Agrobacterium infective clones as well as from a gamma irradiated sachet of parafilm. An autoclavable membrane device was developed to facilitate a simpler approach to undertake virus transmission in biocontained, axenic plant tissue culture. The methodology described here could be used to address a wide range of questions regarding whitefly feeding on plants as well as their transmission of viruses without the expense, facilities, and contamination risks associated with standard approaches.
Multi-source data fusion strategy for the discrimination of Succus Bambusae oral liquid from different manufacturers
Authors: Ying Zehua , Zhang Zhiyong , Feng Huimin , Guo Shubo , Qiu Ping , Li Wenlong 
Published: October 2023

Abstract
This study aims at developing an extensive strategy for distinguishing Succus Bambusae oral liquid (SBOL) from different manufacturers. First, a combination of HS-GC-IMS and Ultra-fast GC E-nose method was established to perform a qualitative analysis of volatile compounds in SBOL. Second, in combination with the results of previous GC-MS studies, a multi-source data fusion strategy based on three signal sources distinguishes SBOL samples from various manufacturers. Multi-level data fusion strategies, including low-level data fusion, mid-level data fusion, and high-level data fusion which were evaluated and compared revealing their advantages and disadvantages in the classification context. The results suggest that the mid-level-SV data fusion strategy exhibits superior discrimination performance, thereby being chosen as the best data fusion strategy. Overall, this study provides a more comprehensive characterization of chemical information of SBOL samples, facilitating the improvement of SBOL quality standards and offering scientific insights and a foundation for the regulation of the SBOL market.