bluuebunny/crossref_metadata_2025_split huggingface dataset:
Developing Teacher‐Leaders for Multilingual Students on the Mexico–United States Border
Authors: Maldonado Saúl I. , Serrano‐Durán Laura , Cuevas‐Antillón Jorge , Jacobo Izela 
Published: January 2025

ABSTRACTThis brief describes how three school districts, one charter school system, a county office of education, and one institution of higher education collaborated to develop the leadership, equity, and access for languages (LEAL) professional development certificate for teacher‐leaders committed to serving multilingual learners on the Mexico–United States border. LEAL was designed and implemented using knowledge, dispositions, and skills for critically conscious pedagogy as the guiding framework to create consensus definitions of teacher‐leaders of multilingual students. Researchers reviewed and interpreted weekly meeting agendas, email correspondence, and the evaluation plan to define and use criteria for the selection of LEAL participants. Researchers implemented an innovative collaborative process of surveys, meetings, and goal‐setting with school district and charter school system administrators to identify current in‐service teachers that would exemplify commitment to serving multilingual learners in their schools and communities. This brief highlights the importance of interinstitutional partnerships for calibrating consistent definitions of teacher‐leaders as well as the value of creating customized seminars and conferences for collegial collaboration across local education agencies (LEAs).
Intervention of a Communication Between PI3K/Akt and β‐Catenin by (−)‐Epigallocatechin‐3‐Gallate Suppresses TGF‐β1‐Promoted Epithelial‐Mesenchymal Transition and Invasive Phenotype of NSCLC Cells
Authors: Hsu Li‐Sung , Lin Chih‐Li , Pan Min‐Hsiung , Chen Wei‐Jen 
Published: January 2025

ABSTRACTThe epithelial‐mesenchymal transition (EMT) assists in the acquisition of invasiveness, relapse, and resistance in non‐small cell lung cancer (NSCLC) and can be caused by the signaling of transforming growth factor‐β1 (TGF‐β1) through Smad‐mediated or Smad‐independent pathways. (−)‐Epigallocatechin‐3‐gallate (EGCG), a multifunctional cancer‐preventing bioconstituent found in tea polyphenols, has been shown to repress TGF‐β1‐triggered EMT in the human NSCLC A549 cell line by inhibiting the activation of Smad2 and Erk1/2 or reducing the acetylation of Smad2 and Smad3. However, its impact on the Smad‐independent pathway remains unclear. Here, we found that EGCG, similar to LY294002 (a specific inhibitor of phosphatidylinositol 3‐kinase [PI3K]), downregulated Akt activation and restored the action of glycogen synthase kinase‐3β (GSK‐3β), accompanied by TGF‐β1‐caused changes in hallmarks of EMT such as N‐cadherin, E‐cadherin, vimentin, and Snail in A549 cells. EGCG inhibited β‐catenin expression and its nuclear localization caused by TGF‐β1, suggesting that EGCG blocks the crosstalk between the PI3K/Akt/GSK‐3β route and β‐catenin. Furthermore, it was shown that EGCG suppressed TGF‐β1‐elicited invasive phenotypes of A549 cells, including invading and migrating activities, matrix metalloproteinase‐2 (MMP‐2) secretion, cell adhesion, and wound healing. In summary, we suggest that EGCG inhibits the induction of EMT by TGF‐β1 in NSCLC not only through a Smad‐dependent pathway, but also through the regulation of the PI3K/Akt/β‐catenin signaling axis.
Genome‐wide association study identifies QTL and candidate genes for grain size and weight in a Triticum turgidum collection
Authors: Mangini G. , Nigro D. , Curci P. L. , Simeone R. , Blanco A. 
Published: January 2025

AbstractWheat breeders are constantly looking for genes and alleles that increase grain yield. One key strategy is finding new genetic resources in the wild and domesticated gene pools of related species with genes affecting grain size. This study explored a natural population of Triticum turgidum (L.) phenotyped for grain weight and size‐related traits in three field trials and genotyped with single nucleotide polymorphism markers spread across the entire genome. The genome‐wide association study analysis identified 39 quantitative trait loci (QTL) for 1000‐kernel weight, grain length, grain width, grain area, and grain aspect consistent in at least two and across environments. Interestingly, 23 QTL for grain‐related traits were grouped in nine QTL clusters located on chromosomes 1A, 1B, 2B, 3B, 4B, 5A, and 6B, respectively. Moreover, most of these QTL support findings from previous QTL analyses and are further strengthened by the known functions of the genes (such as BG2, GS5, and SRS3) and their similarity to genes in other cereal species. QTL clusters harbored genes that participate in various metabolic processes potentially involved in seed development, phytohormone signaling, sugar transport, mitogen‐activated protein kinases signaling, and transcriptional factors (such as MADS‐box and WRKY). Identifying loci controlling grain‐related traits will provide information on the genetic resources available to breeders to improve grain yield, as well as the opportunity to develop close gene markers to be used in marker‐assisted selection programs.
Playing With Story Workshop in the Literacy Classroom
Authors: Lenters Kimberly , Mosher Ronna , Hanzel Stacey 
Published: January 2025

ABSTRACTMaking connections between children's existing means of expression (play, art, and movement) and the intricacies of print is a necessary and time‐honored approach to writing instruction in the early years of school, yet, after kindergarten, one that is easily overlooked. In this article, we examine an approach to writing instruction for first‐grade children that brings together play and written composition. Story Workshop can be a highly accessible, scaffolded means for developing young children's writing practices and skills. However, it is not an approach that is widely adopted in first‐grade classrooms. The authors consider why this might be by examining the structure of Story Workshop as set out by the Opal School and offering examples of two classroom educators who have fruitfully adapted the approach for their first‐grade learners.
Ethical perspective on telemedicine usage in sexual medicine: A friend or a foe?
Authors: Almuhaideb Mana , Bandaru Dhiresh , Chawareb Elia Abou , Yafi Faysal A. , Hammad Muhammed A. M. 
Published: January 2025

AbstractTelemedicine has rapidly integrated into healthcare, overcoming initial barriers such as regulatory restrictions and technological limitations. Its role in sexual medicine, especially urology, has been accelerated by technological advances and the COVID‐19 pandemic. However, as telehealth continues to expand, key ethical challenges emerge, including concerns over privacy, healthcare equity, and informed consent. These challenges are particularly important in sexual medicine, where sensitive patient data and intimate conditions are involved. We aimed to examine the ethical implications of telemedicine in sexual medicine, focusing on data security, consent processes, and healthcare disparities. We further emphasize the importance of maintaining high ethical standards while integrating telemedicine as a complement to traditional care, ensuring that patient outcomes are not compromised.
Vaccine‐Induced Immune Thrombotic Thrombocytopenia Caused by Zoetis PR‐VAC PLUS in Pseudorabies Virus‐Free Danish Purebred Pigs
Authors: Chen Chien‐Cheng 
Published: January 2025

ABSTRACTThis case report highlights a potential vaccine safety concern associated with the Pseudorabies virus (PRV) live vaccine, which warrants further investigation for comprehensive understanding. Vaccine‐induced immune thrombotic thrombocytopenia (VITT), a novel syndrome of adverse events following adenovirus vector COVID‐19 vaccines, was observed after vaccination with Zoetis PR‐VAC PLUS. This led to a 100% morbidity and high mortality among PRV‐free Danish purebred pigs from Danish Genetics Co. Clinical signs and gross presentations due to the post‐thrombotic syndrome (PTS) and pulmonary embolism (PE) included (1) PE causing severe pulmonary oedema, which led to shortness of breath and respiratory failure. PTS causing (2) osteochondrosis (OCD)/leg weakness syndrome; (3) acute gastric ulcers and bleeding; (4) haemorrhagic bowel syndrome; (5) myocardial infarction or heart failure and (6) noticeable varicose veins. (7) Thrombocytopenia along with reddish or purplish spots appeared. Definitive diagnosis was based on the following as human medicine: (1) clinical signs appearing 4–42 days post‐vaccination; (2) thrombocytopenia; (3) presence of thrombus in lung vessels, alveolar septa vessels, gastric vessels and small intestine, as well as other organs, as confirmed by histopathologic examination; (4) positive result from anti‐heparin/PF4 ELISA testing. VITT in pigs, not previously reported, could be attributed to several factors: (1) Differences in diagnosing pigs compared to humans, especially considering that VITT associated with COVID‐19 vaccines has only recently been identified. (2) Challenges in linking clinical signs such as pulmonary oedema, OCD/leg weakness, gastric ulcers and haemorrhagic bowel syndrome to thrombosis. (3) Delayed onset of clinical signs 4–42 days post‐vaccination, unlike common vaccine side effects. (4) Clinical signs were varied and illogical, and ranged from mild to moderate with low mortality if there were no other complications or conditions. (5) Difficulty in diagnosing the condition due to the presence of common pathogens like PRRSV and PCV2. (6) Breeding/genetic factors can be an issue when breeders with strong immunity, who may also be highly sensitive to VITT, are selected. The potential problem of VITT might not be detected because no PR vaccine is used in Denmark.
Statistical and numerical analysis of MHD nanofluid (TiO2/EG) flow on a nonlinear curved stretching surface with heat source: A RSM approach
Authors: Sharma Abhishek , Sharma Ram Prakash 
Published: January 2025

AbstractMany applications in science and engineering use the idea of MHD nanofluid flow past a nonlinear curved stretching surface. Particularly in the development and production of coatings for solar cells, fiber sheets, wires, and optical fibers. From the perspective of such applications, the major objective of existing research is to study the titanium oxide/ethylene glycol (TiO2/EG) nanofluid flow past a nonlinear curved elongating surface in the occurrence of a magnetic field and heat source. In this study, nonlinear coupled partial differential equations with no‐slip and convective boundary constraints have been used to construct the mathematical model that describes the fluid flow. After utilizing the similarity variables, the nondimensional form of equations is approximated by the Runge–Kutta method combined with the Newton iteration scheme. Further, the novelty of the study lies in employing response surface methodology (RSM) to optimize the significance of important factors, which are most likely the Biot number, volume fraction, and the magnetic parameter that impact heat transfer characteristics. This approach facilitates the development of ideal operating conditions for improved performance. In summary, this examination finds that as the volume fraction concentration increases, the shear rate progressively increases, and with a higher Biot number, the heat transfer rate also increases.
Planning Tests, Analysis, Scenarios, Verification, Validation, and Regression
Authors: Myklebust Thor , Stålhane Tor , Vatn Dorthea Mathilde Kristin 
Published: January 2025

Abstract
This chapter focuses on planning tests, analysis, scenarios, verification, validation, and regression testing to ensure the reliability and safety of systems. It outlines the importance of systematic test methodologies, including scenario-based evaluations and simulations, to verify compliance with safety requirements and validate system performance. The chapter emphasizes the role of regression testing in maintaining system integrity after updates, highlighting how agile practices and automated tools can facilitate frequent testing and quicker resolution of potential issues. These methods ensure systems meet safety standards and operate reliably in real-world conditions.
“Everybody knows what a pothole is”: representations of work and intelligence in AI practice and governance
Authors: Bennett SJ , Catanzariti Benedetta , Tollon Fabio 
Published: January 2025

Abstract
In this paper, we empirically and conceptually examine how distributed human–machine networks of labour comprise a form of underlying intelligence within Artificial Intelligence (AI), considering the implications of this for Responsible Artificial Intelligence (R-AI) innovation. R-AI aims to guide AI research, development and deployment in line with certain normative principles, for example fairness, privacy, and explainability; notions implicitly shaped by comparisons of AI with individualised notions of human intelligence. However, as critical scholarship on AI demonstrates, this is a limited framing of the nature of intelligence, both of humans and AI. Furthermore, it dismisses the skills and labour central to developing AI systems, involving a distributed network of human-directed practices and reasoning. We argue that inequities in the agency and recognition of different types of practitioners across these networks of AI development have implications beyond RAI, with narrow framings concealing considerations which are important within broader discussions of AI intelligence. Drawing from interactive workshops conducted with AI practitioners, we explore practices of data acquisition, cleaning, and annotation, as the point where practitioners interface with domain experts and data annotators. Despite forming a crucial part of AI design and development, this type of data work is frequently framed as a tedious, unskilled, and low-value process. In exploring these practices, we examine the political role of the epistemic framings that underpin AI development and how these framings can shape understandings of distributed intelligence, labour practices, and annotators’ agency within data structures. Finally, we reflect on the implications of our findings for developing more participatory and equitable approaches to machine learning applications in the service of R-AI.
Does far-right populism affect immigrants’ working conditions?
Authors: D’Ambrosio Anna , Leombruni Roberto , Razzolini Tiziano 
Published: January 2025

Abstract
Anti-immigrant stances are central in far-right populist propaganda. We investigate whether the electoral success of far-right populist parties affects the labor market conditions of immigrants. Using administrative panel data from Italian manufacturing workers in 1994–2005, we show that higher electoral support for the populist party Lega Nord significantly increases injury risks for foreign workers within job spells. This effect is most pronounced in small firms, which are characterized by lower levels of unionization and employment protection. The increase in injury rates appears driven by task reallocation to overtime and night shifts and to the exploitation of immigrants’ labor supply rigidity. While alternative factors such as import competition and robotization influence injury risk, they fail to explain our core findings.
The algebra of ordinary discourse. On the semantics of Cooper’s logic
Authors: Rivieccio Umberto 
Published: January 2025

Abstract
We develop an algebraic study of W.S. Cooper’s three-valued propositional logic of ordinary discourse (

$$\mathcal{O}\mathcal{L}$$

O
L

). This logic displays a number of unusual features:

$$\mathcal{O}\mathcal{L}$$

O
L

is not weaker but incomparable with classical logic, it is connexive, paraconsistent and contradictory. As a non-structural logic,

$$\mathcal{O}\mathcal{L}$$

O
L

cannot be algebraized by the standard methods. However, we show that

$$\mathcal{O}\mathcal{L}$$

O
L

has an algebraizable structural companion, and determine its equivalent semantics, which turns out to be a finitely-generated discriminator variety. We provide an equational and a twist presentation for this class of algebras, which allow us to compare it with other well-known algebras of non-classical logics. In this way we establish that

$$\mathcal{O}\mathcal{L}$$

O
L

is definitionally equivalent to an expansion of the three-valued logic

$${\mathcal {J}}3$$

J
3

of D’Ottaviano and da Costa, itself a schematic extension of paraconsistent Nelson logic.
Genital graft versus host disease in women after allogeneic hematopoietic stem cell transplantation – a single center experience
Authors: Wilk Goldsher Yulia , Cohen Sacher Bina , Cohen May , Yeshurun Moshe , Sabah Gad , Eitan Ram , Krissi Haim 
Published: January 2025

Abstract
Chronic Graft-versus-host disease (GVHD) is a major complication of allogeneic hematopoietic stem cell transplantation (HSCT), affecting the female genital tract in 25–66% of the patients. This condition, referred to as Genital GVHD is an underdiagnosed gynecologic comorbidity, that can significantly impair quality of life. We aimed to describe the prevalence and management of genital GVHD following HSCT. This retrospective analysis included women who underwent allogeneic HSCT at a single Bone Marrow Transplantation Unit between 2015 and 2020 and were evaluated at a specialized Vulvo-Vaginal Clinic. Diagnosis and severity of genital GVHD were based on the recommendations by the National Institute of Health (NIH), therapeutic options included topical treatments and surgical interventions. Of the thirty-six patients evaluated, 19.4% were diagnosed with genital GVHD. Patients with genital GVHD were older than those with no-genital GVHD (58.42 vs 47.48 years, p = 0.02), and most of them had concurrent multi-organ chronic GVHD (85.71%). Genital GVHD was mostly symptomatic in our cohort (71.42%), clinical findings at the time of diagnosis corresponded with NIH grade 3 (severe disease) in 57.1% of cases. Topical treatments were initiated for all patients with genital GVHD, one required surgical intervention. Genitourinary syndrome of menopause (GSM) was diagnosed among 100% of patients with genital GVHD and among 58.62% of patients without genital GVHD (p = 0.08). In the genital GVHD group, adherence to clinical follow up was limited (43.85%). Genital GVHD should be considered as part of chronic GVHD evaluation after allogeneic HSCT. It is associated with advanced age and the presence of chronic systemic GVHD. Impaired quality of life and limited follow-up within this population emphasize the need for increased awareness and early evaluations.
Maternal cell-free DNA in early pregnancy for preeclampsia screening: a systematic review
Authors: Arbuzova Svitlana , Cuckle Howard 
Published: January 2025

Abstract

Purpose
To quantify the separation between maternal blood cell-free (cf)DNA markers in preeclampsia and unaffected pregnancies and compare with existing markers. This approach has not been used in previous studies.

Methods
Comprehensive systematic literature search of PubMed to identify studies measuring total cfDNA, fetal cf(f)DNA or the fetal fraction (FF) in pregnant women. Included—studies of asymptomatic pregnancies with subsequent preeclampsia (cases) and unaffected pregnancies (controls) tested in the first or second trimester and before the clinical onset of preeclampsia. Excluded—studies not reporting the median or mean, standard deviation, inter-quartile range or range in cases and controls. Information from 26 eligible studies was entered into a meta-analysis to estimate, for each marker, the Mahalanobis distance, a measure of separation between the overlapping distributions in preeclampsia and unaffected pregnancies. This was compared with estimates for mean arterial pressure (MAP), uterine artery Doppler pulsatility index (UtA-PI), pregnancy associated plasma protein (PAPP)-A and placental growth factor (PlGF).

Results
The mean Mahalanobis distance for total cfDNA was 0.44 (95% CI 0.12–0.76), which fell between UtA-PI (0.53) and the absolute value of PAPP-A (– 0.36). For cffDNA the distance was 1.03 (0.37–1.69), which is superior to MAP (0.74), UtA-PI, PlGF (– 0.57) and PAPP-A. The distance for FF was – 0.34 (– 0.56 to – 0.12), similar to PAPP-A.

Conclusion
All three markers have a potential preeclampsia screening role, particularly cffDNA. However, to estimate the screening performance in combination with existing markers further large studies are needed. The current analysis will help in the power calculation for such studies.
New generation low level laser effect on masseter muscle oxygenation, bite force and algometric changes in myofacial pain syndrome: a randomised, placebo-controlled clinical trial
Authors: Karagözoğlu İrem , Demirkol Nermin , Parlar Öz Özge , Yılmaz Sümeyye , Özcan Mutlu 
Published: January 2025

Abstract
The aim of this study was to compare the effectiveness of different types of low level laser treatment (LLLT) in reducing pain levels, changing oxygen saturation and bite force in patients with myofacial pain syndrome (MPS). 45 patients were randomly assigned to three groups: Group 1 (GRR laser, n = 15) received LLLT with Gallium-Aluminium-Arsenide (GaAlAs) diode laser with a wavelength of 904 nm and red laser with a wavelength of 650 nm over masseter muscle region. Group 2 (Nd: YAG laser, n = 15) were treated with Neodymium-doped Yttrium Aluminium Garnet laser with a wavelength of 1064 nm and the same protocol with Nd: YAG laser was performed in the Group 3 (placebo, n = 15) using sham device. Pain was evaluated by visual analogue scale (VAS), change in oxygen concentration in the masseter muscle was measured by functional near-infrared spectroscopy- fNIRS and bite force was measured with Flexiforce sensors before and after treatment. There was a significant decrease in VAS scores after treatment in all three groups. When pain scores were compared, a greater reduction was seen in the Group 1 and Group 2. The change in oxygen saturation level was not statistically significant in all three groups (p > 0.05). Bite force values showed a significant decrease in treatment groups (p < 0.05), while there was no significant change in the placebo group (p > 0.05). Nd: YAG and GRR laser treatments were effective in reducing the pain caused by MPS and in reducing bite force values. Clinically, GRR laser system provides more effective results with its regional and practical application. ClinicalTrials.gov ID: NCT06442553.