bluuebunny/crossref_metadata_2025_split huggingface dataset:
Hereditary spherocytosis in a young female in Eastern Nepal: a case report
Authors: Rayamajhi Anusha , Shrestha Manisha , K.C. Priyanka , Maskey Robin 
Published: February 2024

Introduction and importance:
Hereditary spherocytosis (HS), a rare familial extravascular haemolytic disorder, typically follows an autosomal dominant inheritance pattern with variable expressivity. Despite its classical presentation of anaemia, jaundice, and splenomegaly, HS is infrequently reported among individuals of Asian descent, contributing to its under diagnosis or delayed diagnosis. The primary objective of this case report is to underscore the pivotal role of the osmotic fragility test in diagnosing HS, emphasizing the importance of accurate and timely identification for effective clinical management and improved patient outcomes.

Case presentation:
The patient, without known prior co-morbidities, presented with recurrent abdominal distension, early satiety, and easy fatigability persisting for 6 years. Physical examination revealed icterus, gnathopathy, left hypochondrium tenderness, and palpable splenomegaly. The osmotic fragility of red cells was significantly elevated. The patient underwent optimization before splenectomy, receiving immunization against encapsulated bacteria. Packed red blood cell transfusions were administered to achieve optimal haemoglobin levels. Follow-up showed symptom relief, significantly improving the patient’s quality of life.

Clinical discussion:
This case underscores the challenges of delayed HS diagnosis, with the patient enduring symptoms for years before seeking appropriate medical attention. Overlooking the simplicity and cost-effectiveness of an osmotic fragility test prolonged the diagnostic journey, emphasizing the impact on overall well-being.

Conclusion:
HS remains underdiagnosed, especially in our regions. The osmotic fragility test emerges as an economical diagnostic tool in resource-limited settings, particularly when spherocytosis is absent in the peripheral blood smears. Its inclusion in diagnostic protocols can expedite accurate HS identification and enhance patient outcomes.
Safety, pharmacokinetics, and potential neurological interactions of ivermectin, tafenoquine and chloroquine in Rhesus Macaques
Authors: Vanachayangkul Pattaraporn , Kodchakorn Chanikarn , Ta-aksorn Winita , Im-erbsin Rawiwan , Tungtaeng Anchalee , Tipthara Phornpimon , Tarning Joel , Lugo-Roman Luis A. , Wojnarski Mariusz , Vesely Brian A. , Kobylinski Kevin C. 
Published: February 2024

AbstractIvermectin could be used for malaria control as treated persons are lethal to blood feedingAnopheles, resulting in reduced transmission. Tafenoquine could be used in combination with ivermectin to clear persons of liver stagePlasmodium vivaxreservoir and as a prophylactic in high-risk populations. The safety of ivermectin and tafenoquine has not been evaluated. As earlier forms of 8-aminoquinolones were neurotoxic, and ivermectin is an inhibitor of the P-glycoprotein blood brain barrier transporter, there is concern that co-administration could be neurotoxic. The safety and pharmacokinetic interaction of tafenoquine, ivermectin, and chloroquine was evaluated in Rhesus macaques. No clinical, biochemistry, or hematological outcomes of concern were observed. The Cambridge Neuropsychological Test Automated Battery was employed to assess potential neurological deficits following drug administration. Some impairment was observed with tafenoquine alone and in the same monkeys with subsequent co-administrations. Co-administration of chloroquine and tafenoquine resulted in increased plasma exposure to tafenoquine. Urine concentrations of the 5,6 orthoquinone TQ metabolite were increased with co-administration of tafenoquine with ivermectin. There was an increase in ivermectin plasma exposure when co-administered with chloroquine. No interaction of tafenoquine on ivermectin was observedin vitro. Chloroquine and trace levels of ivermectin, but not tafenoquine, were observed in the cerebrospinal fluid. The 3”-O-demethyl ivermectin metabolite was observed in macaque plasma but not in urine or cerebrospinal fluid. Overall, the combination of ivermectin, tafenoquine, and chloroquine did not have clinical, neurological, or pharmacological interactions of concern in macaques, therefore this combination could be considered for evaluation in human trials.
Protocol for Cerebellar Stimulation for Aphasia Rehabilitation (CeSAR): A randomized, double-blind, sham-controlled trial
Authors: Lammers Becky , Sydnor Myra J. , Cust Sarah , Kim Ji Hyun , Yenokyan Gayane , Hillis Argye E. , Sebastian Rajani 
Published: February 2024

AbstractIn this randomized, double-blind, sham-controlled trial of Cerebellar Stimulation for Aphasia Rehabilitation (CeSAR), we will determine the effectiveness of cathodal tDCS (transcranial direct current stimulation) to the right cerebellum for the treatment of chronic aphasia (>6 months post stroke). We will test the hypothesis that cerebellar tDCS in combination with an evidenced-based anomia treatment (semantic feature analysis, SFA) will be associated with greater improvement in naming untrained pictures (as measured by the change in Philadelphia Picture Naming Test), 1-week post treatment, compared to sham plus SFA. We will also evaluate the effects of cerebellar tDCS on naming trained items as well as the effects on functional communication, content, efficiency, and word-retrieval of picture description, and quality of life. Finally, we will identify imaging and linguistic biomarkers to determine the characteristics of stroke patients that benefit from cerebellar tDCS and SFA treatment. We expect to enroll 60 participants over five years. Participants will receive 15, 25-minute sessions of cerebellar tDCS (3-5 sessions per week) or sham tDCS combined with 1 hour of SFA treatment. Participants will be evaluated prior to the start of treatment, one-week post-treatment, 1-, 3-, and 6-months post treatment on primary and secondary outcome variables. The long-term aim of this study is to provide the basis for a Phase III randomized controlled trial of cerebellar tDCS vs sham with concurrent language therapy for treatment of chronic aphasia.Trial registrationThe trial is registered withClinicalTrials.govNCT05093673.
Human Motor Cortex Encodes Complex Handwriting Through a Sequence of Primitive Neural States
Authors: Qi Yu , Zhu Xinyun , Xiong Xinzhu , Yang Xiaomeng , Ding Nai , Wu Hemmings , Xu Kedi , Zhu Junming , Zhang Jianmin , Wang Yueming 
Published: February 2024

AbstractHow the human motor cortex (MC) orchestrates sophisticated fine movements such as handwriting remains a puzzle1–3. Here, we investigate this question through Utah array recordings from human MC hand knob, during imagined handwriting of Chinese characters (306 characters tested, 6.3 ± 2.0 strokes per character). We find MC programs the writing of complicated characters by sequencing a small set of primitive states: The directional tuning of motor neurons remains stable within each primitive state but strongly varies across states. Furthermore, the occurrence of a primitive state is encoded by a separate set of neurons not directly involved in movement control. By automatically identifying the primitive states and corresponding neuronal tuning properties, we can reconstruct a recognizable writing trajectory for each character (84% improvement in reconstruction accuracy compared with baseline). Our findings unveil that skilled, sophisticated movements are decomposed into a sequence of primitive movements that are programmed through state-specific neural configurations, and this hierarchical control mechanism sheds new light on the design of high-performance brain-computer interfaces.
The Guinea Pig: A New Model for Human Preimplantation Development
Authors: Canizo Jesica Romina , Zhao Cheng , Petropoulos Sophie 
Published: February 2024

ABSTRACTPreimplantation development is an important window of human embryogenesis. During this time, the initial lineages are formed which largely govern embryo competence, implantation, and ultimately the developmental potential of the fetus. Ethical constraints and limitations surrounding human embryos research often necessitates the use of a model system. We now identify the guinea pig as a promising small animal model, which closely recapitulates early human embryogenesis in terms of the timing of compaction, early-, mid-, and late-blastocyst formation and implantation. We also observe conserved spatio-temporal expression of key lineage markers, roles of both Hippo and MEK-ERK signaling and an incomplete X-Chromosome inactivation. Further, our multi-species analysis highlights the spatio-temporal expression of conserved and divergent genes during preimplantation development. The guinea pig serves as an exciting new model which will enhance developmental and pluripotency research and can be leveraged to better understand the longer term impact of early exposures on offspring outcomes.
Neurometabolite differences in Autism as assessed with Magnetic Resonance Spectroscopy: a systematic review and meta-analysis
Authors: Thomson Alice R. , Pasanta Duanghathai , Arichi Tomoki , Puts Nicolaas A. 
Published: February 2024

Abstract1H-Magnetic Resonance Spectroscopy (MRS)is a non-invasive technique that can be used to quantify the concentrations of metabolites in the brain in vivo. MRS findings in the context of autism are inconsistent and conflicting. We performed asystematic review and meta-analysisof MRS studies observing glutamate and gamma-aminobutyric acid (GABA), as well as brain metabolites involved in energy metabolism (glutamine, creatine), neural integrity (e.g. n-acetyl aspartate (NAA), choline, myo-inositol) and neuro-inflammation (glutathione) in autism cohorts. Data were extracted and grouped by metabolite, brain region and several other factors before calculation of standardised effect sizes. Overall, we find significantly lower concentrations of GABA and NAA in autism, indicative of disruptions to the balance between excitation/inhibition within brain circuits, as well as neural integrity. Further analysis found these alterations are most pronounced in autistic children and in limbic brain regions relevant to autism phenotypes. Additionally, we show how study outcome varies due to demographic and methodological factors (e.g. medication use), emphasising the importance of conforming with consensus study designs and transparent reporting.HighlightsWe performed a meta-analysis ofMagnetic Resonance Spectroscopyfindings in autism.We find significantly lower concentrations of GABA and NAA in children with autism.These alterations were most pronounced in limbic brain regions.Demographic factors (including sex) contribute to MRS study outcome variation.
Intraindividual variability and stability in rumination: examining the effect of rumination on negative affect across domains
Authors: Shi Xiaolin (Crystal) , Huang Xiaoting , Guo Zimeng , Gordon Susan Elizabeth 
Published: February 2024

Purpose
The purpose of this paper is to investigate the influence of employees’ trait rumination on the variability of their state rumination and the continuing influence on their negative affect at home.

Design/methodology/approach
A time-lagged experience sampling method was used for the data collection from full-time employees in the hotel industry. The hypotheses were tested with multilevel modeling using a random coefficient modeling approach.

Findings
Hotel employees who are high in trait rumination generally show high levels of state rumination and greater within-person variability in state rumination over time. Additionally, the negative effects of workplace state rumination can last until employees come home and the next day before going to work. Furthermore, employees who are high in trait rumination are more likely to be influenced by state rumination, as they experience more negative affect after arriving home.

Practical implications
Rumination has been shown to decrease hotel employee overall well-being. The findings of this study provide suggestions for remedial measures that can be taken by hotel organizations to help employees address ruminative thinking.

Originality/value
Drawing on response styles and work/family border theories, this study contributes to the rumination literature by considering both trait rumination and state rumination in a broader context. For a comprehensive understanding of the dynamic temporal characteristics of state rumination, this study considers the net intraindividual variability of state rumination as the outcome of trait rumination.
Festivalization of business events: exploring a new strategy for designing more engaging conference experiences
Authors: Jung Shinyong , Fan Alei , Lehto Xinran , Shin Hhye Won 
Published: February 2024

Purpose
This study aims to explore a potential conference experience design strategy, namely, festivalization. It investigates the potential festivalization effects on conference attendees in two formats of business conferences: virtual and in-person.

Design/methodology/approach
A series of two scenario-based experimental studies were conducted. A series of one-way analysis of covariance and PROCESS procedures (Model 6) were performed for data analysis.

Findings
The inclusion of festivalization elements significantly enhances positive responses of attendees, especially for in-person conferences. This effect is further explained by a serial mediation effect, where enhanced perceived values and conference engagement play key roles in improving attendees’ conference experience.

Practical implications
By incorporating festivalization elements, conference organizers can create a more engaging and satisfying event experience for attendees. This can lead to greater satisfaction, positive word-of-mouth and increased registrations.

Originality/value
This study represents a pioneering effort in revealing the underlining mechanisms that explain how festivalization affects attendee engagement and subsequent behaviors in business event management in both face-to-face and virtual settings.
A positive psychology intervention to enhance mental well-being of Syrian refugees in the Netherlands
Authors: Muller-Dugic José , Beckers Pascal , Braakman Mario 
Published: February 2024

Purpose
Syrian refugees in the Netherlands frequently suffer from mental health problems. It is argued that mental health not only consists of the absence of psychiatric disorders but also of the presence of mental well-being. However, there is little attention to the mental well-being of refugees, and no intervention exists that focuses on fostering the mental well-being of refugees. Therefore, the new culturally sensitive positive psychology intervention “Mosaic” was developed and implemented in collaboration with the target audience and local partners. Mosaic is offered in the Arabic language, and the content is focused on (re)finding purpose in life and (re)discovering life values and subsequently acting upon these values. The purpose of this study is to assess the effect of Mosaic on the mental well-being of Syrians in the Netherlands.

Design/methodology/approach
The effect of Mosaic on the mental well-being of Syrians in the Netherlands is assessed by conducting a randomized controlled trial (RCT) with a waitlist control group.

Findings
Postintervention within sample t-tests showed that the intervention group (n = 66) experienced significantly more overall mental well-being, emotional well-being and purpose in life right after participating in the intervention when compared to the preintervention measurement. The effect on purpose in life persisted six months later. These improvements were not found among the control group (n = 60).

Originality/value
Mosaic is the first positive psychology intervention in the Netherlands that was developed for and in collaboration with Syrian refugees. To the best of the authors’ knowledge, this study is also the first study in the Netherlands and one of the first ones in Europe that assesses the effect of positive psychology for refugees specifically.
Unlocking auditors’ perceived external employability: exploring antecedents and behavioral consequences
Authors: Pruijssers Jorien Louise 
Published: February 2024

PurposeIn a rapidly changing career landscape where lifelong job security is no longer guaranteed, this study investigates how audit firms play an important role in shaping their employees’ career perceptions and the subsequent effects on auditor behavior. Specifically, it explores the link between audit firms’ career development initiatives and auditors’ perceptions of external employability – an important determinant of auditor behavior. Using the framework of social exchange theory, the study investigates how perceived external employability affects both relational and operational behaviors of auditors.Design/methodology/approachThe study employs structural equation modeling on survey data from 359 auditors.FindingsThe results indicate that when audit firms actively support career development, it positively contributes to auditors’ perceived external employability. A higher perceived external employability, in turn, leads to positive behavioral outcomes among auditors, including stronger relational behaviors (such as professional commitment) and operational behaviors (including heightened professional skepticism and reduced behaviors that could compromise audit quality).Originality/valueThis study uncovers a paradox where perceived external employability, typically viewed as a risk, emerges as a potent driver of desirable auditor behavior. In today’s dynamic career landscape, emphasizing individual-centered and flexible careers, these results highlight the benefits of perceived external employability. Rather than undermining audit services, increased perceived external employability driven by firm investments in auditors’ careers acts as a catalyst for desirable auditor behavior. Organizational support in terms of career development practices creates an environment where auditors are more committed, professionally skeptical and uphold the quality of audit services.
Application of fuzzy-set qualitative comparative analysis (fsQCA) in hospitality and tourism research: a bibliometric study
Authors: Eluwole Kayode Kolawole , Lasisi Taiwo Temitope , Parvez M. Omar , Cobanoglu Cihan 
Published: February 2024

PurposeFuzzy-set qualitative comparative analysis (fsQCA) is explored as a transformative tool rooted in complexity theory, shedding light on uncertainties shaping real-world decisions in tourism, with a focus on its application in the hospitality domain.Design/methodology/approachThis study systematically evaluates fsQCA’s application in hospitality and tourism research, employing bibliometric analysis to scrutinize the published literature since its induction in 2011. The research seeks to understand the evolving usage by qualitatively reviewing impactful studies based on total citations.FindingsThe study reveals the ascendancy of fsQCA as a predominant approach in hospitality and tourism studies, particularly in illuminating decision-making paradigms in key sectors like destination and hotel selections and entrepreneurial orientations. However, an absence of fsQCA applications in gastronomy and wine tourism is identified, signaling uncharted territories for future inquiry.Research limitations/implicationsTheoretical implications include paradigm shifts to complexity theory, configural analysis and asymmetric algorithms. Practical implications involve improved decision-making and tailored marketing, benefiting industry practitioners. Limitations include potential academic bias, while future research suggests exploring sub-sectors, sustainability and emerging technologies.Originality/valueThis study identifies gaps in the fsQCA application and pioneers its examination within the hospitality domain, offering a unique perspective on understanding intricate relationships and configurations among variables. The study emphasizes the efficacy of asymmetric methodologies in elucidating behavioral nuances in hospitality and tourism, providing a foundation for future inquiries to expand horizons and unravel the nuanced applications of fsQCA in this research domain.
Understanding the influence of environmental triggers on tourists' pro-environmental behaviors in the Pakistan’s tourism industry
Authors: Raza Syed Ali , Khan Komal Akram , Qamar Bushra 
Published: February 2024

PurposeThe research analyzes the influence of three environmental triggers, i.e. awareness, concern and knowledge on environmental attachment and green motivation that affect tourists' pro-environmental behavior in the Pakistan’s tourism industry. Furthermore, this study has analyzed the moderating role of moral obligation concerning environmental attachment and green motivation on tourists' pro-environmental behavior.Design/methodology/approachData were gathered via a structured questionnaire by 237 local (domestic) tourists of Pakistan. Furthermore, the data were examined by employing SmartPLS.FindingsFindings demonstrate that all three environmental triggers have a positive and significant relationship with environmental attachment and green motivation. Accordingly, environmental attachment and green motivation promote tourists' pro-environmental behavior. Furthermore, the moderating role of moral obligations has also been incorporated in the study. The finding reveals a strong and positive relationship among environmental attachment and tourists' pro-environmental behaviors during high moral obligations. In contrast, moral obligations do not moderate association between green motivation and tourists' pro-environmental behavior. Therefore, competent authorities should facilitate tourists to adopt environmentally friendly practices; which will ultimately promote pro-environmental behavior.Originality/valueThis study provides useful insights regarding the role of tourism in fostering environmental attachment and green motivation that sequentially influence tourist pro-environmental behavior. Secondly, this research has employed moral obligations as a moderator to identify the changes in tourists’ pro-environmental behavior based on individuals' ethical considerations. Hence, the study provides an in-depth insight into tourists' behavior. Lastly, the present research offers effective strategies for the tourism sector and other competent authorities to increase green activities that can embed the importance of the environment among individuals.