bluuebunny/crossref_metadata_2025_split huggingface dataset:
Are digital health interventions valuable to support patients with cancer and caregivers? An umbrella review of web‐based and app‐based supportive care interventions
Authors: Fournier Valentyn , Duprez Christelle , Grynberg Delphine , Antoine Pascal , Lamore Kristopher 
Published: November 2023

AbstractBackgroundDigital health technologies have expanded tremendously in the last two decades, creating an emerging research and clinical field. They are regarded as cost‐effective, and their use in healthcare is prioritized by many countries. However, the constant evolution of these technologies has led to an abundance of related literature. Thus, we conducted an umbrella review to identify and characterize digital supportive care interventions for patients with cancer and their relatives.MethodsA preregistered umbrella review was conducted (PROSPERO registration number CRD42022333110). Five databases were searched (Embase, PsycINFO, PubMed, CINAHL, and the Cochrane Library). To be considered, studies had to be systematic reviews or meta‐analyses, be performed on pediatric or adult patients with cancer or survivors or their relatives, report results on web‐based or app‐based supportive care interventions, and measure psychological, functional, or behavioral variables or quality of life related to cancer. The methodological quality of the studies was assessed using the AMSTAR‐2 tool.FindingsTwenty eligible studies were identified. Most of the included studies reported results from adult patients with cancer. Globally, digital interventions were shown to be effective for physical activity in patients with cancer but had mixed results regarding emotional outcomes and quality of life. Additionally, a lack of methodological quality was noted for most of the included reviews.DiscussionDigital supportive care interventions could be an effective tool in cancer care for some outcomes. Recommendations have been formulated for further research in this field using adapted methodologies for the development of digital health interventions.
Mapping the cytoskeletal architecture of renal tubules and surrounding peritubular capillaries in the kidney
Authors: Kumaran Girishkumar Kaitholil , Hanukoglu Israel 
Published: November 2023

AbstractThe human kidney includes ~1 million nephrons which are long U‐shaped tubules with convoluted segments that serve as filtration units. During the passage of the ultrafiltrate through a nephron, electrolytes and nutrients are re‐absorbed into peritubular capillaries. The fluid remaining in the distal end of the renal tubules flows through the collecting ducts into the ureter. In this study, we generated high‐resolution images of mouse kidney sections using confocal microscopy with only two fluorescently tagged biomarkers, F‐actin binding phalloidin and CD34 antibodies as a marker for blood vessels. In tile‐scan images of entire sections of mouse kidney (composed of >1000 images), the tubule segments are easily identifiable by their F‐actin bundles on cell borders and the outlines of the peritubular capillaries by CD34 immunofluorescence. In the inner stripe of the medulla, the vascular bundles composed of vasa recta (straight vessels) could be easily distinguished from the peritubular capillaries by their full circular shapes. The highly vascular inner medulla and the papilla similarly have straight capillaries. About 95% of kidney volume is composed of renal tubules and blood vessels. Thus, our results show that relatively simple cytoskeletal mapping can be used to visualize the structural organization of the kidney. This method can also be applied to examine pathological changes in the kidney.
Regulation of circulating thyroid hormone levels by hypothalamic tanycytes and hypophysial pars tuberalis‐specific cells and their morphological and gene‐ and protein‐expression changes under different photoperiods
Authors: Kameda Yoko 
Published: November 2023

AbstractThyroid hormone in the hypothalamus acts as a key determinant of seasonal transitions. Thyroid hormone‐levels in the brain are mainly regulated by the hypothalamic tanycytes and pituitary pars tuberalis (PT)‐specific cells. TSHβ produced by the PT‐specific cells stimulates Dio2 expression and decreases Dio3 expression of the tanycytes. Both tanycytes and PT‐specific cells in photosensitive animals exhibit remarkable changes of morphological appearance and expressions of genes and proteins under different photoperiods. Long photoperiods induce increased gene‐ and protein‐expressions and active features. Short photoperiods cause the decreased gene‐ and protein‐expressions and inactive features. In the PT, expressions of TSHβ, common α‐subunit of glycoprotein hormones (α‐GSU), and MT1 receptor of melatonin receptors and eyes absent 3 change under different photoperiods. Diurnal rhythms of α‐GSU mRNA expression are observed in the PT of Djungarian hamsters. Hes1, Nkx2.1, and LIM homeodomain gene 2 (Lhx2) are involved in the differentiation of PT. In the hypothalamic tanycytes, expressions of Dio2, Dio3, vimentin, serine/threonine kinase 33, GPR50, Nestin, Retinoid signaling genes (retinaldehyde dehydrogenase 1, cellular retinol binding protein 1, and Stra6), monocarboxylate transporter 8, and neural cell adhesion molecule change under different photoperiods. Rax, Lhx2, Nfia/b/x, and fibroblast growth factor 10 are involved in the differentiation of tanycytes.
Terminal organization of the corticospinal projection from the arm/hand region of the rostral primary motor cortex (M1r or old M1) to the cervical enlargement (C5–T1) in rhesus monkey
Authors: Morecraft Robert J. , Ge Jizhi , Stilwell‐Morecraft Kimberly S. , Lemon Roger N. , Ganguly Karunesh , Darling Warren G. 
Published: November 2023

AbstractHigh‐resolution anterograde tracers and stereology were used to study the terminal organization of the corticospinal projection (CSP) from the rostral portion of the primary motor cortex (M1r) to spinal levels C5–T1. Most of this projection (90%) terminated contralaterally within laminae V–IX, with the densest distribution in lamina VII. Moderate bouton numbers occurred in laminae VI, VIII, and IX with few in lamina V. Within lamina VII, labeling occurred over the distal‐related dorsolateral subsectors and proximal‐related ventromedial subsectors. Within motoneuron lamina IX, most terminations occurred in the proximal‐related dorsomedial quadrant, followed by the distal‐related dorsolateral quadrant. Segmentally, the contralateral lamina VII CSP gradually declined from C5–T1 but was consistently distributed at C5–C7 in lamina IX. The ipsilateral CSP ended in axial‐related lamina VIII and adjacent ventromedial region of lamina VII. These findings demonstrate the M1r CSP influences distal and proximal/axial‐related spinal targets. Thus, the M1r CSP represents a transitional CSP, positioned between the caudal M1 (M1c) CSP, which is 98% contralateral and optimally organized to mediate distal upper extremity movements (Morecraft et al., 2013), and dorsolateral premotor (LPMCd) CSP being 79% contralateral and optimally organized to mediate proximal/axial movements (Morecraft et al., 2019). This distal to proximal CSP gradient corresponds to the clinical deficits accompanying caudal to rostral motor cortex injury. The lamina IX CSP is considered in the light of anatomical and neurophysiological evidence which suggests M1c gives rise to the major proportion of the cortico‐motoneuronal (CM) projection, while there is a limited M1r CM projection.
Energy aware optimal routing model for wireless multimedia sensor networks using modified Voronoi assisted prioritized double deep Q‐learning
Authors: Suseela Sellamuthu , Krithiga Ravi , Revathi Muthusamy , Sudhakaran Gajendran , Bhavadharini Reddiyapalayam Murugeshan 
Published: November 2023

SummaryThe energy hole problem is critical in Wireless Multimedia Sensor Network (WMSN), wherein the nodes closer to the sink node will expire sooner than the outer sub‐regions. Because they transmit their packet and forward the outer sub‐regions packet to the sink. Hence, a hole arises near the sink node after a very short time. Thus, an energy‐aware optimal routing model is introduced in this research using Modified Voronoi‐assisted prioritized double deep Q‐learning (PDDQL). Initially, the sensor nodes are deployed using the Voronoi cell structure that splits the entire region of interest into different Voronoi polygons. However, the Voronoi diagram will not always predict an efficient route because of the nodes at a Voronoi edge or vertex outside the transmission range. To tackle this issue, a new Voronoi diagram is proposed that depends on the maximum horizontal transmission range to remove the portion of Voronoi edges uncovered by the sensor node. After the deployment, a PDDQL algorithm is used to select the Relay Nodes based on their remaining energy. The proposed PDDQL determines an alternate route to transmit the packet if an energy hole problem has occurred in WMSN. The analysis of a proposed routing protocol based on the assessment measures like packet delivery ratio, average residual energy, number of alive nodes, and average end‐to‐end delay accomplished the value of 198.33 (ms), 2.05 (J), 100, and 0.85, respectively.
A DFT Investigation of B‐Doped C3N as Single Atom Electrocatalysts for N2‐to‐NH3 Conversion
Authors: Ma Pengfei , Du Peiru , Song Wei , Wang Jinlong 
Published: November 2023

AbstractThe NH3 synthesis from N2 plays an important role in the ecological cycle and industrial production. Different from industrial NH3 synthesis with high pollution and energy consumption, electrocatalytic NH3 synthesis is favored because of its environmental protection, energy saving, ambient reaction conditions and other characteristics. However, due to the low efficiency and poor reaction selectivity of the existing electrocatalysts, which can not be used actually, the development of new electrocatalysts for nitrogen reduction reaction (NRR) is particularly urgent. Herein, we designed a series of transition metal atoms anchored B‐doped defective C3N surface (TM@B2C3N) as single‐atom catalysts. Through the screening process of N2 adsorption activation, N2H formation and NH3 desorption, finally the excellent electrocatalysts with strong stability and high activity (Cr@B2C3N and Mn@B2C3N) were obtained. After simulating the entire pathway, it was found that the NRR process on Cr@B2C3N and Mn@B2C3N via consecutive and distal pathways with the lowest limiting potential of −0.42 and −0.52 V, which have the good ability to inhibit hydrogen evolution reaction. Finally, the electronic properties were analyzed, and the reason for their high catalytic activity was summarized. This work provides a new idea for the rational design of NRR electrocatalysts and promotes the practical application of electrocatalysts.
Potent Anticancer Activity of a Dinuclear Gold(I) bis‐N‐Heterocyclic Imine Complex Related to Thioredoxin Reductase Inhibition in Vitro
Authors: Park Mihyun , Schmidt Claudia , Türck Sebastian , Hanusch Franziska , Hirmer Simone V. , Ott Ingo , Casini Angela , Inoue Shigeyoshi 
Published: November 2023

AbstractA dinuclear gold(I) complex featuring a strongly donating bis‐N‐heterocyclic imine ligand was synthesised and characterised by different methods, including single crystal X‐ray diffraction (SC‐XRD) analysis. The compound has been tested for its antiproliferative effects in a panel of human cancer cell lines in vitro, showing highly selective anticancer effects, particularly against human A549 non‐small cell lung cancer cells (NSCLC), with respect to non‐tumorigenic cells (VERO). The accumulation of the compound in A549 and VERO cells was studied by high‐resolution continuum source atomic absorption spectrometry (HRCS‐AAS), revealing that the anticancer effects are not particularly related to the different amounts of gold taken up by the cells over 72 h. Enzyme inhibition studies to evaluate the activity of the seleno‐enzyme thioredoxin reductase (TrxR) in cancer cell extracts show that the gold(I) compound is a potent inhibitor (IC50=0.567±0.208 μM), while the free ligand is ineffective. This result correlates with the observed compound's selectivity towards A549 cells overexpressing the enzyme.
Non‐additive effects between genotypes: Implications for competitive fitness assays
Authors: Xiao Changyi , Duarri‐Redondo Sara , Thorhölludottir Dagny A. V. , Chen Yiwen , Schlötterer Christian 
Published: November 2023

AbstractCompetitive fitness assays are widely used in evolutionary biology and typically rely on a reference strain to compare different focal genotypes. This approach implicitly relies on the absence of interaction between the competing genotypes. In other words, the performance of the reference strain must not depend on the competitor. This report scrutinized this assumption by competing diverged Drosophila simulans populations against a common reference strain. We detected strong evidence for interaction between the competing genotypes: (1) Frequency‐dependent selection was common with opposite effects in genetically diverged populations. (2) Temporal heterogeneity of fitness estimates, which can be partially attributed to a competitor‐specific delay in the eclosion of the reference strain. We propose that this inconsistent behavior of the reference strain can be considered a specific case of a genotype × environment interaction. Focal populations could modify the environment of the reference strain, either indirectly by altering the microbiome composition and food availability or directly by genotype‐specific cannibalism. Our results provide new insights into the interaction of diverged genotypes and have important implications for the interpretation of competitive fitness assays.
Interstitial pregnancy management: A multicentric analysis of 98 patients from the FRANCOGENT group comparing surgery and medical treatment
Authors: Dabreteau Thomas , Puchar Anne , Nyangoh Timoh Krystel , Fauconnier Arnaud , Legendre Guillaume , Touboul Cyril , Lavoué Vincent , Thubert Thibault , Lecarpentier Edouard , Haddad Bassam , Dabi Yohann 
Published: November 2023

AbstractObjectiveTo evaluate the outcomes associated with each therapeutic option for patients diagnosed with interstitial pregnancy (IP).MethodsWe conducted a multicentric retrospective cohort study within the departments of Gynecology and Obstetrics involved in the Francogent research group. Women treated for an interstitial pregnancy between January 2008 to December 2019 were included. Three therapeutic options were evaluated: surgical treatment (ST); in situ methotrexate combined with systemic methotrexate (IS‐MTX); and systemic methotrexate (IM‐MTX). Success of first‐line treatment was defined by hCG negativation (<5I U/L). Secondary outcomes included the need for secondary surgical procedure, secondary medical treatment, emergency surgery, postoperative complications, duration of hospitalization, and delay before hCG negativation.ResultsA total of 98 patients were managed for IP: 42 (42.9%) patients had IM‐MTX; 34 (34.7%) had IS‐MTX; and 22 (22.4%) had ST. First‐line treatment was successful in all patients of the ST group (22/22, 100%), in 31% of patients within the IM‐MTX group (13/42) and 70.6% (24/34) in the IS‐MTX group. The sole parameter associated with the risk of treatment failure was the mode of methotrexate administration. The size of the gestational sac or the presence of fetal heartbeat was not associated with decreased medical treatment (IS or IM–MTX) efficiency.ConclusionEither ST or IS‐MTX are good options for IP treatment associated with high success rates. A single‐dose regimen of IM‐MTX is less efficient than IS‐MTX or ST. Symptomatic patients with severity criteria should always undergo emergency surgery. IP remains a high‐risk condition that should be managed, whenever possible, in referral centers to potentialize the chances of favorable outcomes.
Editors' perspectives on the selection of reviewers and the quality of reviews
Authors: Cengher Mirela , LeBlanc Linda A. 
Published: November 2023

AbstractThis article describes the outcomes of a survey of 93 editors in chief and associate editors of behavior‐analytic journals. We sought information about variables that influence their judgment of the selection of reviewers, selection of review panels, and quality of reviews. When selecting reviewers, participants rated highly expertise on the topic, history of conducting good reviews, and history of writing constructive and respectful reviews. When selecting review panels, participants rated highly stratifying reviewers based on their expertise, avoiding conflicts of interest, and the matching based on the area of expertise between reviewers and authors. When evaluating the quality of a review, participants rated highly considerations related to research design, the science underlying the main idea, and accurate interpretations of the data. Participants did not rate copyediting as important. Overall, the extent to which reviewer selection was influenced by membership in underrepresented groups varied. These findings can inform the development of training programs for teaching peer‐review repertoires.
Incidence, clinical course, and risk factors in the development of femoral pseudoaneurysm after atrial fibrillation ablation
Authors: Koyama Takafumi , Tobita Kazuki , Kawaguchi Tatsuto , Uchida Shuhei , Koyama Eiji , Kodera Nobuhisa , Tamaki Yusuke , Otomaru Yuri , Miyashita Hirokazu , Yamashita Takayoshi , Mizuno Shingo , Murakami Masato , Saito Shigeru 
Published: November 2023

AbstractBackgroundPrevious studies have revealed the risk factors for femoral pseudoaneurysms (FPA). Most data on FPA are based on coronary and peripheral interventions, with limited studies focusing on atrial fibrillation (AF) ablation. However, patient backgrounds, anticoagulation regimens, and vascular access methods differ. In addition, a standard for managing FPA after AF ablation remains elusive due to the difficult nature of achieving thrombosis in pseudoaneurysms.MethodsThis single‐center, retrospective, observational study included 2805 consecutive patients who underwent AF ablation between January 2016 and December 2021. All patients underwent femoral artery and vein punctures. Puncture sites were checked 1 day post‐procedure.ResultsA total of 23 FPA patients were identified during the study period. Multivariate logistic regression analysis showed that hypertension (odds ratio 4.66, 95% confidence interval: 1.38–15.71; p = .0032) and warfarin use (odds ratio 3.83, 95% confidence interval: 1.40–10.45; p = .021) were significantly associated with the occurrence of FPA. The compression success rate was low (22%). There were nine and six patients in the endovascular treatment (EVT) and ultrasound‐guided thrombin injection (UGTI) groups, respectively. The success rates were 100% and 84% in the EVT and UGTI groups, respectively. The length of hospital stay after FPA treatment was 2.1 days in the EVT group and 1.3 days in the thrombin group.ConclusionWe must be careful about post‐procedural FPA, especially for hypertension and warfarin‐using patients. Treatment of pseudoaneurysms with anticoagulants is unlikely to achieve hemostasis, and an early switch to invasive treatments, such as EVT, should be considered.
Adjuvant Radiotherapy in Moderately Advanced (T3) Oral Cavity Cancers
Authors: Wang Ronald S. , Chow Michael S. , Gordon Alex J. , Santacatterina Michele , Vaezi Alec E. , Tam Moses M. , Givi Babak 
Published: November 2023

ObjectiveTo investigate the impact of adjuvant radiotherapy in isolated locally advanced oral cavity cancers (pT3N0M0) without adverse features.MethodsWe selected all patients from the National Cancer Database (2004–2019) who underwent surgical treatment where the final pathology was T3N0M0 with negative margins. Demographics, details of treatment, and outcomes were abstracted. The impact of radiotherapy on survival was assessed with univariable, multivariable, and propensity score‐matched analyses.ResultsWe identified 571 patients in our survival cohort. Most were male (348, 60.9%), and median age was 65. Less than one‐third (176, 30.8%) received adjuvant radiotherapy. The median length of follow‐up was 29 months. Overall, adjuvant radiotherapy was associated with improved survival (87.2% vs. 77.7%, at 2 years, p < 0.01). On multivariable analysis controlling for age and comorbidities, this survival difference persisted (HR: 0.62, 95% CI: 0.43–0.90, p = 0.01). In a propensity score‐matched population of 278 patients matched on age and comorbidities, adjuvant radiotherapy was still associated with longer survival (87.4% vs. 78.5%, p = 0.014).ConclusionIn our study, adjuvant radiotherapy was associated with improved survival in completely excised locally advanced oral cavity tumors (T3N0M0). However, a significant proportion of patients do not receive adjuvant radiotherapy. These findings highlight the need for continued efforts to promote guideline‐recommended care.Level of Evidence3 Laryngoscope, 134:2236–2242, 2024
The Self‐Administered Screening Questionnaire for Parkinson's Disease‐Associated Psychosis (SASPAP)
Authors: Koneru Vindhya , Espay Alberto J. , Cole Allan J. , Weintraub Daniel , Crist Kathleen , Pascual Maria B. , Ondo William G. 
Published: November 2023

AbstractBackgroundPsychosis is a common manifestation of Parkinson's disease (PD), and a major source of caregiver burden, nursing home placement, and mortality. Psychosis symptoms are often not volunteered during the clinic visit because of embarrassment or lack of insight, and there is no validated screening scale. We compare a new self‐administered psychosis screening questionnaire against the Parkinson's Disease Psychosis Scale (PDPS) and physician interview as the gold standard assessments.ObjectiveTo create and validate the Self‐Administered Screening Questionnaire for PD‐Associated Psychosis (SASPAP).MethodsThe questionnaire was developed through a modified Delphi method by a committee of two neurologists, a psychiatrist, a patient, and patient advocate and underwent several rounds of revisions, including patient β‐testing. It was provided by staff at intake to 250 consecutive patients diagnosed with PD, at the Methodist Hospital Movement Disorders Clinic, and separately to their caregivers when available. Later, the PDPS and a general psychosis interview were administered by PD specialists without knowledge of the screening questionnaire responses.ResultsTwo hundred and fifty consecutive patients with PD (mean age, 68.6 ± 7.0; mean age of PD onset, 62.7 ± 10.5 years; 35.2% female) were included. The screening questionnaire was positive for psychosis (any of the four questions positive) in 33.6% of patients. Compared to the gold standard, the SASPAP sensitivity was 87.8% and the specificity 92.3%.ConclusionThis four‐question self‐administered screening questionnaire for PD psychosis demonstrated high diagnostic accuracy compared with the gold standard assessments and can be self‐completed at visit intake. © 2023 International Parkinson and Movement Disorder Society.