bluuebunny/crossref_metadata_2025_split huggingface dataset:
Treatment of peripheral neuropathy in type 2 diabetes with epalrestat combined with sulodexide
Authors: Chen Wenjun , Zhou Xiaoming 
Published: January 2025

Purpose: To analyze the efficacy of epalrestat combined with Sulodexide in the treatment of diabetic peripheral neuropathy in type 2 diabetes.
Methods: A total of 140 patients with type 2 diabetic peripheral neuropathy, who were treated at the Zhanjiang Central People's Hospital between February 2022 and February 2023, were selected as subjects. They were randomly divided into two groups using a computer- generated random number table. The control group (n = 70) received epalrestat treatment, while the study group (n = 70) was treated with a combination of epalrestat and Sulodexide11. Efficacy, nerve conduction velocity, levels of inflammatory factors and oxidative stress markers were compared between groups.
Results: After treatment, total effective rate in study group was 97.14 %, which was higher than that of control group (85.71 %; p < 0.05). Sensory nerve conduction velocity (SCV) and motor nerve conduction velocity (MCV) of the common peroneal nerve and median nerve in study group were significantly faster than those in control group (p < 0.05). Levels of serum high-sensitivity C-reactive protein (hs-CRP), interleukin-6 (IL-6), procalcitonin (PCT) and tumor necrosis factor-α (TNF-α) in study group were significantly lower than those in control group (p < 0.05). Total antioxidant capacity (T-AOC) and superoxide dismutase (SOD) levels in study group were higher than those in control group, while malondialdehyde (MDA) level was lower than control group (p < 0.05).
Conclusions: Epalrestat combined with Sulodexide in treatment of diabetic peripheral neuropathy in type 2 diabetes improves efficacy, accelerates nerve conduction velocity, reduces inflammatory factor levels and decreases oxidative stress response. Further studies are necessary to accurately verify the combination therapy value using epalrestat and Sulodexide in treating peripheral neuropathy associated with type 2 diabetes.
Antiplasmodial and cytotoxic activities of Jussiaea linifolia G. Don extracts
Authors: Kuranen Fabian , Nnadi Charles , Agbo Matthias 
Published: January 2025

Purpose: To evaluate the in vivo and in vitro antiplasmodial activity of Jussiaea linifolia extracts using validated models.Methods: Methanol extract was partitioned into n-hexane, ethyl acetate and n-butanol fractions and subjected to antiplasmodial and cytotoxic activity assays. The in vivo assay adopted Peter’s four-day suppressive and Ranes curative tests to estimate Plasmodium berghei NK47 growth suppression while the in vitro antiplasmodial activities were performed using chloroquine-sensitive Plasmodium falciparumNF54 and L6 mammalian myoblast to determine growth inhibition and cytotoxicity respectively.Results: Acute toxicity test showed that the methanol extract displayed LD50 > 5000 mg/kg. The in vitro assays revealed that the extract and ethyl acetate fraction elicited significantly higher IC50 of 1.15 μg/mL (L6 83.2 μg/mL) and 0.785 μg/mL (L6 > 100 μg/mL), respectively against P. falciparum compared with n-hexane (> 100 μg/mL; L6 5.89 μg/mL) and n-butanol (48.1 μg/mL; L6 12.84 μg/mL) fractions. In the in vivo suppressive model, 400 mg/kg of ethyl acetate soluble fraction elicited a 97.1 % (p < 0.05; mean survival time > 21 days) P. berghei suppression compared with untreated group. Also, the ethyl acetate soluble evoked the highest suppression of parasitemia (94.17 %) in the curative model when compared with untreated. The extract and fractions of J. linifolia were found to restore packed cell volume in infected mice to their respective baselines compared with continued decline in untreated group.Conclusion: The study validates the traditional use of J. linifolia as an antimalarial decoction in some rural communities and shows that the ethyl acetate soluble fraction of methanol extract could be a source of lead antiplasmodial compounds.
Enhancing Sustainable Development Goals (SDGs) for Rural Tourism Communities: The Case of Mae Kampong Village, Chiang Mai, Thailand
Authors: Rakpathum Watthanasakon , Siripipatthanakul Supaprawat , Phuangsuwan Penpim , Charoenporn Chuleerat 
Published: January 2025

Objective: This study proposes sustainable communities for rural tourism, using Mae Kampong Village in Chiang Mai, Thailand, as a case study.

The theoretical framework: The determinants of a sustainable rural community-based tourism model include (1) cultural experiences, (2) homestay, hotel, street food, and shop experiences (services, prices, and facilities), and (3) eco-friendly practices and natural experiences.

Method: The researchers utilized a meticulous approach, which involved purposive sampling, to select Mae Kampong Village. This research is a systematic review that gathers secondary data and observations for the primary data. Content analysis was employed to understand and synthesize the data.

Results and Discussion: The findings indicate that sustainable rural tourism communities based on environmental awareness encompass cultural experiences, tourist experiences (services, pricing, facilities), and eco-friendly actions inside the village.

Research Implications: Sustainable rural tourism should employ Mae Kampong Village as a best practice model for sustainable rural tourism regarding cultural experiences, responsible tourism practices, and environmental management to accomplish sustainable development growth (SDGs).

Originality/Value: The village offers authentic encounters with Lanna culture through tourist experiences, natural experiences, and community connections. However, this qualitative observation was without respondents. Additional questionnaires and interviews are recommended for further studies to comprehensively examine the village's environmental awareness activities, such as organic farming and renewable energy. This will help tourists and locals benefit from sustainable economic growth while safeguarding the village's natural and cultural heritage. Emphasizing community-based tourism and providing inexpensive and accessible experiences will be instrumental in achieving sustainability goals.
Bibliometric Analysis of the Socialization of Islamic Inheritance Law in the Scopus Database and Its Contribution to Sustainable Development Goals (SDGs)
Authors: Muthoifin  , Rachmadie Fawazzanne Typhano , Apriantoro Muhamad Subhi , Nirwana Andri , Bernardlauwers B. , Islam Rezaul , Nuha  
Published: January 2025

Purpose: This study, titled "Bibliometric Analysis of the Socialization of Islamic Inheritance Law in the Scopus Database and Its Contribution to Sustainable Development Goals (SDGs)," aims to map the development and direction of research on Islamic inheritance law from 2019 to 2024. It seeks to highlight the role of this field in addressing key SDG objectives, such as gender equality (SDG 5) and justice (SDG 16).

Theoretical Framework: The theoretical framework focuses on the increasing relevance of Islamic inheritance law in global academic discussions, particularly in the Asian region, with Indonesia as a significant contributor. The study acknowledges its limitations, as it exclusively analyzes Scopus-indexed publications and does not incorporate other national or international databases.

Methods: The research employs a bibliometric approach to analyze 109 publications related to Islamic inheritance law. Data analysis was conducted using R/R-Studio and Excel, while VOSviewer was utilized to visualize document citations and keyword networks. This methodological combination provides a robust framework for understanding publication trends and research dynamics.

Results and Conclusion: The findings reveal a 26% annual growth rate in publications, with the highest output in 2023. Indonesia is the leading contributor, supported by affiliations such as Ar-Raniry State Islamic University and Imam Bonjol State Islamic University. Elfia emerges as the most prolific author. These results underscore the increasing global attention to Islamic inheritance law and its alignment with the SDGs, particularly in promoting equitable access to resources and fostering institutional integrity.

Research implications: The implications of this study include providing a foundational reference for scholars interested in this field, identifying research gaps, and encouraging the exploration of diverse international data sources. This focus on expanding the scope of analysis aims to enhance the global relevance and inclusivity of future research.

Originality/value: The novelty of this study lies in its comprehensive bibliometric approach, mapping global trends, institutional contributions, and author productivity in Islamic inheritance law research over the past five years. This work contributes to a deeper understanding of how Islamic inheritance law aligns with and supports SDG objectives.
The SDG 3 Enhancement Through Health-Service Management in Post-Conflict Afghanistan: Resource Allocation, Training, Community Engagement, and Data Use
Authors: Noori Mohammad Taleb , Amron Amron , Pakarti Piji , Jumanto Jumanto 
Published: January 2025

Purpose: This study aims to identify critical factors that enhance health service delivery in post-conflict Afghanistan, focusing on effective resource allocation, comprehensive training programs for healthcare workers, community engagement, and the utilization of Health Management Information Systems (HMIS) data. The novelty of this research lies in its integrative approach to addressing health service delivery in post-conflict settings. Unlike previous studies that have often examined these factors in isolation, this research uniquely combines them to provide a comprehensive framework for improving healthcare outcomes.

Method: Using a narrative literature review methodology, this study synthesizes findings from peer-reviewed journals, government reports, and international health organization publications.

Results and Discussion: The findings reveal that targeted resource allocation is essential for reducing health inequalities and improving service delivery. Comprehensive training programs enhance the skills and knowledge of healthcare providers, leading to better service quality and management efficiency. Community engagement fosters a sense of ownership and accountability, improving health practices and outcomes. Effective utilization of HMIS data enhances decision-making, monitoring, and resource allocation. The study concludes that a holistic approach, integrating these elements, is necessary to build resilient health systems in post-conflict settings.

Research Implications: The implications for policymakers and health managers include prioritizing resource allocation, training, community engagement, and data utilization to improve health outcomes. Future research should focus on developing and implementing strategies that incorporate these factors to strengthen health systems in similar environments.

Originality/Value: The novelty or urgency of this study is underscored by the profound disruptions in Afghanistan's healthcare system following the Taliban's takeover in August 2021. Decades of conflict have severely impacted healthcare delivery, exacerbating existing challenges and creating new barriers to accessing essential services. The withdrawal of international aid and restrictive policies have further strained the healthcare infrastructure, particularly affecting vulnerable populations such as women and children. This urgent backdrop justifies the need for a comprehensive analysis to identify strategies that can effectively address these challenges.
Legal Principles of Customs Declaration of Goods in the Course of Foreign Economic Activity
Authors: Ivanchenko Eduard Pylypovych , Teremetskyi Vladyslav Ivanovych , Sidliar Viktoriia Volodymyrivna , Terletskii Anatoliy Volodymyrovych , Bodnar-Petrovska Olha Borysivna , Yatsenko Fedir Petrovut 
Published: January 2025

Objective: The research is devoted to the nature and peculiarities of the legal principles of customs declaration of goods in the course of foreign economic activity, taking into account the provisions of customs legislation and scientific research on this issues.

Theoretical Framework: This study examines the legal principles underpinning customs declaration as a procedural element of customs law and a socio-economic phenomenon. It integrates principles of legality, efficiency, and transparency, exploring their application in customs regimes and alignment with international standards such as the SAFE Framework of Standards and the Kyoto Convention.

Method: The article uses a combination of general and special methods of cognition, in particular, methods of analysis, synthesis, dialectical, formal legal and logical-semantic methods, to achieve its goal and solve its tasks.

Results and Discussion: The authors of the article have revealed the essence of customs declaration in the structure of customs business and carry out a comprehensive study of its interrelation with other customs procedures. The characteristic features of the principles of various customs procedures have been highlighted. The essence and peculiarities of implementation of certain principles of customs activities and customs declaration have been analyzed. The directions of formation and implementation of international standards in the customs sphere, taking into account the legal basis of customs declaration and customs in general have been proposed.

Contributions: Since customs declaration is a component of customs procedures, it has been proposed to extend a significant part of the principles of regulation of procedures to customs declaration, taking into account its specificity outlined in the proposed definition. It has been indicated that the current customs legislation does not contain a structured approach to the comprehensive reflection of the principles of declaration through its integration into the general process of customs procedures. The existing approaches to differentiation of the principles of customs and its procedures have been supported. The significance of the study for improving the legal regulation of customs declaration and promoting the efficiency of the customs system has been emphasized.
TINGKAT KEPUASAN KONSUMEN OBAT TRADISIONAL APOTEK BARENG DI KECAMATAN KLOJEN KOTA MALANG
Authors: Aditya Ayuning Siwi Mayang , Mardianto Rudy 
Published: January 2025

A pharmacy is a pharmaceutical service facility where pharmaceutical practice is carried out by pharmacists. Consumer satisfaction means that the performance of a service is at least the same as expected or exceeds what is expected. This research was conducted to determine the level of satisfaction of traditional medicine consumers at pharmacies. This research uses a non-experimental quantitative method with a descriptive approach, with a population of pharmacy consumers and 100 samples, and an accidental sampling technique. The level of consumer satisfaction can be measured using variables, reliability, responsiveness, confidence, physical evidence and empathy. Satisfaction level measurement was carried out using a questionnaire and 5 quality measurement variables. The results obtained on the variable reliability 80.07% level of satisfaction, responsiveness 80.1% level of satisfaction, confidence 74.4% level of satisfaction, empathy 78.8% level of satisfaction and tangible 73.88% satisfaction level. And an average satisfaction value of 77.45% consumer satisfaction was obtained from 5 variables, which means consumers felt satisfied
Visual Outcome and Intraocular Lens Rotational Stability after Cataract Surgery with Multifocal Toric Intraocular Lens Implantation
Authors: Mrukwa-Kominek Ewa , Malec-Pleskacz Agnieszka , Sarnat-Kucharczyk Monika 
Published: January 2025

Purpose:To evaluate long-term refractive, visual outcomes and patient satisfaction following capsular bag implantation of a multifocal toric intraocular lens (IOL).Setting:Department of Ophthalmology, Professor K. Gibinski University Clinical Center, Medical University of Silesia, Katowice, Poland.Methods:This prospective, non-randomized study enrolled cataract patients with the presence of preoperative corneal astigmatism of values higher than 1.5 D. All patients were operated on by a single surgeon. After removal of cataract and injection of viscoelastic material, an intraocular was implanted into the capsular bag (M-flex T, Rayner Intraocular Lenses Limited, Hove UK). Postoperative examinations were performed at 1 day, 1 week, 1 month, 3 months, 6 months and the last visit (between 12 and 48 months).Results:Thirty-five eyes were included in the analysis. The mean uncorrected distance visual acuity, corrected distance visual acuity, uncorrected near visual acuity, binocular distance visual acuity and binocular near visual acuity increased from 0.28 ± 0.23, 0.58 ±0.34, 0.29 ± 0.21, 0.46 ±0.29, 0.45 ±0.25 before the surgery to 0.85 ± 0.23, 0.88 ± 0.16, 0.68 ± 0.15, 0.94 ±0.13, 0.71 ±0.14, respectively, at the 3-month follow-up. All the values remained at the same level of statistical significance (P<0.0001). The mean preoperative cylinder power was -2.15 D, which was reduced to -0.01 D, 0.43 D at the 3-month visit. Higher contrast sensitivity was evident throughout all spatial frequencies of 3, 6, 12 and 18 after the surgery. The patients’ satisfaction, measured by the VF-14 questionnaire, was significantly higher after the surgery, 82.67%, compared to with 41.62% before surgery. Moreover, a significant increase in spectacle independence after surgery was evident, with 90.20% spectacle free.Conclusions:Implantation of a multifocal toric intraocular lens is a good option for patients to reduce their dependency on spectacles. The visual outcomes after surgery contribute to a high level of patient satisfaction and an improvement in quality of life.
"THEORY OF NATURAL LAW AND ITS ESSENCE "
Authors:   "Law College of Kashkadarya region ", Amirov Sanjar 
Published: January 2025

"This article examines the principles and tenets of natural law theory in modern jurisprudence, focusing on its relationship to constitutional interpretation and legal reasoning. In particular, natural law theory grounds law in the universal and immutable principles of justice inherent in natural orders and provides an ethical basis for assessing the legitimacy of legal norms and institutions. This article explores the philosophical foundations of natural law theory and its implications for governance, justice, and human rights, drawing on the work of historical and contemporary natural law theorists Aristotle, Thomas Aquinas, and John Finnis. In particular, how natural law principles influence constitutionalism, the rule of law, and the relationship between law and morality has been explored, the relevant literature has been reviewed, and the ongoing conflicts between natural law theory and legal positivism have been identified. discussed in theoretical debates. discussed. Different views on the nature of natural law, its sources, and its relationship to morality are also highlighted. Based on the idea that certain moral principles are inherent in nature and human reason, natural law has passed through the stages of philosophy, law, and ethics over the centuries. The analysis of the complexities of natural law helps to understand the essence of the eternal concept that unites the fulcrums of human civilization.
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Rancang Bangun Sistem Monitoring Deteksi Dini Kebakaran Ruang Server Berbasis Iot
Authors: Candra Supriadi  , Priyadi  
Published: January 2025

Penelitian ini bertujuan untuk merancang sistem monitoring deteksi dini kebakaran pada ruang server. Kebakaran merupakan ancaman serius yang dapat mengakibatkan kerusakan fatal pada peralatan di ruang server dan potensi kehilangan data pada storage. Untuk menunjang penelitian yang memanfaatkan otomatisasi dan hal yang bersifat real time, maka diperlukan komunikasi antara sensor-sensor dan software yang juga disebut teknologi Internet of Things (IoT). Dalam penelitian ini, sensor-sensor yang dimaksud yaitu Flame Sensor yang berguna sebagai pendeteksi radiasi dari nyala api, Sensor MQ 2 sebagai pendeteksi asap dan Sensor DHT 11 untuk mendeteksi perubahan suhu yang signifikan. Untuk mempermudah dalam pemantauan, juga di lengkapi dengan laman web server yang dapat diakses dengan mudah serta menggunakan beberapa output, antara lain buzzer sebagai sirine bahaya, pilot lamp untuk memberikan sinyal visual adanya suhu yang tidak normal serta outpur exhaust fan untuk membantu sirkulasi udara di dalam ruang server. Implementasi dalam rancang bangun sistem monitoring ini diharapkan dapat membantu memastikan performa server dalamkondisi yang selalu optimal dan mengurangi resiko kebakaran yang lebih fatal serta dapat mengurangi beban kerja staf pengelola di Dinas Kependudukan dan Pencatatan Sipil Kabupaten Semarang.
The Small Mobile Ozone Lidar (SMOL): instrument description and first results
Authors: Chouza Fernando , Leblanc Thierry , Wang Patrick , Brown Steven S. , Zuraski Kristen , Chace Wyndom , Womack Caroline C. , Peischl Jeff , Hair John , Shingler Taylor , Sullivan John 
Published: January 2025

Abstract. Ozone profile measurements at high temporal and vertical resolution are needed to better understand physical and chemical processes driving tropospheric ozone variability and to validate the tropospheric ozone measurements from spaceborne missions such as TEMPO (Tropospheric Emissions: Monitoring Pollution). As part of the Tropospheric Ozone Lidar Network (TOLNet) efforts allocated to provide such measurements and leveraging on the experience of more than 20 years of ozone lidar measurements at Table Mountain Facility, the JPL lidar group developed the SMOL (Small Mobile Ozone Lidar), an affordable differential absorption lidar (DIAL) system covering all altitudes from 200 to 10 km above ground level (a.g.l.). The transmitter is based on a quadrupled Nd:YAG laser, which is further converted into a 289/299 nm wavelength pair using Raman shifting cells, and the receiver consists of three ozone DIAL pairs, including one that is 266/289 nm and two that are 289/299 nm. Two units were deployed in the Los Angeles basin area during the Synergistic TEMPO Air Quality Science (STAQS) and Atmospheric Emissions and Reactions Observed from Megacities to Marine Areas (AEROMMA) campaigns in summer 2023. The comparison with airborne in situ and lidar measurements shows very good agreement, with systematic differences below 10 % throughout most of the measurement range. An additional comparison with nearby surface ozone measuring instruments indicates unbiased measurements by the SMOL lidars down to 200 m a.g.l. Further comparison with the Goddard Earth Observing System Composition Forecast (GEOS-CF) model suggests that such lidars are a critical tool to perform model validation and can potentially be used for assimilation to air quality forecasts.