bluuebunny/crossref_metadata_2025_split huggingface dataset:
Toroidal Magnetic Flux Budget in Mean-field Dynamo Model of Solar Cycles 23 and 24
Authors: Pipin Valery V. , Kosovichev Alexander G. 
Published: February 2024

Abstract
We study the toroidal magnetic flux budget of the axisymmetric part of a data-driven 3D mean-field dynamo model of Solar Cycles 23 and 24. The model simulates the global solar dynamo that includes the effects of the formation and evolution of bipolar magnetic regions (BMRs) emerging on the solar surface. By applying Stokes’s theorem to the dynamo induction equation, we show that the hemispheric magnitude of the net axisymmetric toroidal magnetic field generation rate in the bulk of the convection zone can only partially be estimated from the surface parameters of the differential rotation and the axisymmetric radial magnetic field. The contribution of the radial integral along the equator, which is mostly due to the rotational radial shear at the bottom of the convection zone, has the same magnitude and is nearly in phase with the effect of the surface latitudinal differential rotation. Also, the toroidal field generation rate estimate strongly depends on the latitudinal profile of the surface radial magnetic field near the poles. This profile in our dynamo models significantly deviates from the polar magnetic field distribution observed during the minima of Solar Cycles 22, 23, and 24. The cause of this discrepancy requires further observational and theoretical studies. Comparing the 2D axisymmetric and the 3D nonaxisymmetric dynamo models, we find an increase in the toroidal field generation rate in the 3D model due to the surface effects of BMRs, resulting in an increase in the axisymmetric poloidal magnetic field magnitude.
Corneal densitometry changes in keratoconus patients after intrastromal corneal ring segments implantation
Authors: Basiony Ahmed I. , Mohammad Abdulfattah Mohammad M. E. , Ibrahim Asmaa M. 
Published: February 2024

BackgroundKeratoconus (KC) is an ectatic corneal disorder characterized by progressive corneal thinning with myopic astigmatism. Intrastromal corneal ring segments (ICRS) have been broadly selected as a surgical intervention for KC correction to delay the need of keratoplasty. The purpose of this study was to evaluate the corneal densitometry changes in the various annuluses and depths in KC corneas after intrastromal corneal ring segment (ICRS) implantation and to correlate those changes with the other optical and refractive outcomes.MethodologyThis was a prospective interventional study included 56 eyes of 40 patients with KC who underwent femtosecond laser-assisted Keraring ICRS implantation. The uncorrected and best-corrected visual acuities (UCVA and BCVA), refraction, keratometry, Q-value, thinnest corneal location thickness (TCLT), and corneal densitometry in all the annular zones were assessed preoperatively and 90 days after surgery.ResultsFollowing the ICRS implantation after 3 months, when compared to preoperatively, the UCVA, BCVA, improved significantly from 0.21±0.12 and 0.44±0.15 to 0.27±0.12 and 0.58±0.15 (P<0.001) and spherical equivalent (SE) decreased significantly, from −5.28±1.65 D to −4.05±1.24 D (P<0.001) whereas the K1, K2, Km, Kmax, reduced significantly from 47.67±4.10 D, 51.39±4.74 D, 49.44±4.28 D, and 57.78±7.35 D, to 44.28±2.86 D, 46.84±3.42 D, 45.45±2.98 D, and 53.89±5.49 D (P<0.001) respectively. Corneal astigmatism, and Q-value were markedly improved from 3.73±2.17 D and −0.99±0.5 to 2.55±2.08 and −0.28±0.5 (P<0.001) .As regard corneal densitometry there was a significant elevation in the mean density of 2–6 mm annulus for the anterior and posterior layers (P=0.001), of 2–6 mm and 6–10 mm annuluses and total diameter for the central layer (P<0.001,P=0.047, andP<0.001, respectively), and of 2–6 mm annulus and total diameter for the total corneal thickness (P<0.001 andP=0.014, respectively). In contrast, a significant decline in the densitometry readings was observed in the 10–12 annulus for the central, posterior, and total corneal layers (P=0.003,P<0.001, andP=0.008, respectively). The percentage changes in the corneal densitometry readings did not significantly correlate with the percentage changes in the UCVA, BCVA, SE, CA and Q value. The percentage changes in the central and total 2–6 mm annuluses densities correlated negatively with the percentage changes in the K1 (r=−0.30,P=0.025 and r=−0.29,P=0.029, respectively), K2 (r=−0.33,P=0.013 and r=−0.31,P=0.021, respectively), and Km (r=−0.34,P=0.010 and r=−0.33,P=0.014, respectively).ConclusionsThe ICRS implantation results in significant changes in corneal densitometry specifically in the central corneal layer and in the 2–6 mm annulus, with an inverse correlation with keratometric values of the front corneal surface. Besides, ICRS leads to substantial improvements of refractive status, visual acuity and corneal keratometry and asphericity.
Corneal and epithelial thickness mapping in diabetic patients using optical coherence tomography
Authors: Abdel Twaab Menna A.M. , el Gendy Heba , El-Sayed Mohamed M. , Arfeen Shaimaa A. 
Published: February 2024

Purpose
To evaluate corneal and epithelial thickness using the anterior segment optical coherence tomography and to correlate these changes with major disease parameters, that is duration of the disease, status of control (glycated hemoglobin level), and stage of diabetic retinopathy.

Patients and methods
Corneal and epithelial thickness profile of 25 patients diagnosed with diabetes mellitus and 25 healthy individuals were measured by anterior segment optical coherence tomography. Full ophthalmological examination of all patients was done. The disease duration and the glycated hemoglobin levels were recorded.

Results
In diabetic patients, there was nonsignificant thinning in mean central epithelial thickness (P=0.14). The mean central corneal thickness is slightly thicker, however, it did not reach significance (P=0.051). There was statistically significant thickening in central stromal thickness (P=0.015). There was a significant negative correlation between the severity of retinopathy and superior epithelial thickness (P=0.037). The duration of the disease showed significant correlation with most of epithelial thickness values, however, HA1c level was not found to have any statistically significant effect on corneal and epithelial parameters.

Conclusion
Chronic metabolic stress of diabetes has an impact on corneal epithelium and stroma. Severity of diabetic retinopathy should be considered as a risk factor during corneal surgeries to avoid epithelial and stromal-associated complications.
Neuroendocrine differentiation in a metachronous metastatic deposit in a case of mature growing ovarian teratoma: A rare occurrence
Authors: Jain Divakar , Patkar Shraddha , Agarwal Jasmine , Menon Santosh , Goel Mahesh 
Published: February 2024

ABSTRACT
Growing teratoma syndrome is a rare condition seen in non seminomatous germ cell tumor after completion of chemotherapy. Ectodermal, mesodermal and endodermal differentiation is commonly seen in mature teratoma. neuroendocrine differentiation in a metastatic deposit of mature teratoma is rarely reported. We are presenting a case of neuroendocrine differentiation in a long standing metastatic deposit of a mature teratoma.
Profile of Sleep-related Breathing Disorders in Chronic Obstructive Pulmonary Disease-obstructive Sleep Apnea Overlap Syndrome
Authors: Ish Pranav , Agrawal Sumita , Rathi Vidushi , Gupta Nitesh , Kumar Rohit , Gupta Mansi , Mittal Anshul , Behera Debasis , Suri J. C. 
Published: February 2024

ABSTRACT

Introduction:
Overlap syndrome (OS) is defined by the combined occurrence of obstructive sleep apnea (OSA) and chronic obstructive pulmonary disease (COPD). Sleep-related breathing disorders (SRBDs) in OS can also manifest with central sleep apnea (CSA) and hypoventilation; besides OSA.

Methods:
This study was carried out to evaluate various SRBD in OS and its therapeutic implications patients having postbronchodilator obstruction in spirometry with respiratory symptoms were classified as COPD. Those found to have an apnea–hypopnea Index (AHI) >5/h in polysomnography (PSG) were diagnosed as OS. All 37 patients diagnosed as OS underwent a subsequent positive airway pressure (PAP) titration.

Results:
On the evaluation of the SRBD, over half (51%) of the patients had OSA with no hypoventilation. More than one-third of the patients (35%) had associated hypoventilation with OSA, three patients had hypercapnic CSA, and two patients had hypocapnic CSA with Cheyne–Stokes breathing (CSA-CSB). The OSA group was easily titrated and corrected by CPAP therapy. OSA with hypoventilation group had underlying COPD with severe obstruction requiring bilevel PAP titration. Patients with CSA-CSB were elderly hypertensive patients with congestive heart failure who were corrected by PAP and optimization of cardiac medications. Patients with hypoventilation and hypercapnic CSA were most difficult to titrate and needed a backup rate along with PAP therapy for correction. On classifying patients on the basis of severity of OSA and COPD, there was no correlation found between AHI and forced expiratory volume 1 (FEV1). Patients with mild COPD with severe OSA were easily titrated with CPAP with a mean pressure of 8 cm H20. The most challenging cases were with severe COPD with severe OSA who required high pressures in both exhalation PAP and inspiratory PAP titration; two of such patients required backup rate by spontaneous/timed mode of PAP therapy.

Conclusions:
There are many profiles of SRBD in OS, and a detailed in-hospital PSG with a PAP titration can help in effectively managing the patients.
Beckwith–Wiedemann Syndrome Diagnosed in the Early Second Trimester in Two Fetuses with Isolated Omphalocele
Authors: Yang Yan-Dong , Li Dong-Zhi 
Published: February 2024

Abstract
Beckwith–Wiedemann syndrome (BWS) is an imprinting disorder caused by various genetic or epigenetic alterations involving growth regulatory genes located on chromosome 11p15.5 region. Conventionally, most cases of BWS are diagnosed during the neonatal period or early childhood. Early prenatal diagnosis is very important because it provides information regarding the prognosis, guidance of delivery preparation, and postnatal care plan. We report two cases of BWS diagnosed in utero using exome sequencing (ES) after the early identification of fetal omphalocele and normal findings of microarray and methylation analyses. Case 1 carried a de novo CDKN1C c.694C>T (p.Gln232*) variant. Case 2 carried a familial CDKN1C c.827_828delinsAA (p.Phe276*) variant; another member in the family presented with features of BWS. In both cases, no macrosomia and visceromegaly were demonstrated. Although fetal omphalocele was identified in the first trimester, invasive testing was delayed to the early second trimester for methylation in the two cases. Fetal omphalocele should not be regarded as just an abdominal wall defect. When a fetal omphalocele was identified, a detailed family history, especially with searching for the signs of BWS in familial members, should be undertaken. For an omphalocele, ES is an option for patients after normal microarray and methylation analyses.
Customised weight-based volume contrast media protocol for multiphase abdominal computed tomography
Authors: Yap Lilian Poh Poh , Sani Fadhli Mohamed , Chung Eric , Gowdh Nadia Fareeda Muhammad , Ng Wei Lin , Wong Jeannie Hsiu Ding 
Published: February 2024

Abstract

Introduction:
Multiphase computed tomography (CT) using fixed volume contrast media may lead to high radiation exposure and toxicity in patients with low body weight. We evaluated a customised weight-based protocol for multiphase CT in terms of radiation exposure, image quality and cost savings.

Methods:
A total of 224 patients were recruited. An optimised CT protocol was applied using 100 kV and 1 mL/kg of contrast media dosing. The image quality and radiation dose exposure of this CT protocol were compared to those of a standard 120 kV, 80 mL fixed volume protocol. The radiation dose information and CT Hounsfield units were recorded. The signal-to-noise ratio, contrast-to-noise ratio (CNR) and figure of merit (FOM) were used as comparison metrics. The images were assessed for contrast opacification and visual quality by two radiologists. The renal function, contrast media volume and cost were also evaluated.

Results:
The median effective dose was lowered by 16% in the optimised protocol, while the arterial phase images achieved significantly higher CNR and FOM. The radiologists’ evaluation showed more than 97% absolute agreement with no significant differences in image quality. No significant differences were found in the pre- and post-CT estimated glomerular filtration rate. However, contrast media usage was significantly reduced by 1,680 mL, with an overall cost savings of USD 421 in the optimised protocol.

Conclusion:
The optimised weight-based protocol is cost-efficient and lowers radiation dose while maintaining overall contrast enhancement and image quality.
Identification of anti-gastric cancer effects and molecular mechanisms of resveratrol: From network pharmacology and bioinformatics to experimental validation
Authors: Ma Ying-Qian , Zhang Ming , Sun Zhen-Hua , Tang Hong-Yue , Wang Ying , Liu Jiang-Xue , Zhang Zhan-Xue , Wang Chao 
Published: February 2024

BACKGROUND
Gastric cancer (GC) is one of the most aggressive malignancies with limited therapeutic options and a poor prognosis. Resveratrol, a non-flavonoid polyphenolic compound found in a variety of Chinese medicinal materials, has shown excellent anti-GC effect. However, its exact mechanisms of action in GC have not been clarified.
AIM
To identify the effects of resveratrol on GC progression and explore the related molecular mechanisms.
METHODS
Action targets of resveratrol and GC-related targets were screened from public databases. The overlapping targets between the two were confirmed using a Venn diagram, and a “Resveratrol-Target-GC” network was constructed using Cytoscape software version 3.9.1. The protein-protein interaction (PPI) network was constructed using STRING database and core targets were identified by PPI network analysis. The Database for Annotation, Visualization and Integrated Discovery database was used for Gene Ontology (GO) and Kyoto Encyclopedia of Genes and Genomes (KEGG) enrichment analysis. A “Target-Pathway” network was created by using Cytoscape 3.9.1. The RNA and protein expression levels of core target genes were observed using the Cancer Genome Atlas and the Human Protein Atlas databases. DriverDBv3 and Timer2.0 databases were used for survival and immune infiltration analysis. Subsequently, the findings were further verified by molecular docking technology and in vitro experiments.
RESULTS
A total of 378 resveratrol action targets and 2154 GC disease targets were obtained from public databases, and 181 intersection targets between the two were screened by Venn diagram. The top 20 core targets were identified by PPI network analysis of the overlapping targets. GO function analysis mainly involved protein binding, identical protein binding, cytoplasm, nucleus, negative regulation of apoptotic process and response to xenobiotic stimulus. KEGG enrichment analysis suggested that the involved signaling pathways mainly included PI3K-AKT signaling pathway, MAPK signaling pathway, IL-17 signaling pathway, TNF signaling pathway, ErbB signaling pathway, etc . FBJ murine osteosarcoma viral oncogene homolog (FOS) and matrix metallopeptidase 9 (MMP9) were selected by differential expression analysis, and they were closely associated with immune infiltration. Molecular docking results showed that resveratrol docked well with these two targets. Resveratrol treatment arrested the cell cycle at the S phase, induced apoptosis, and weakened viability, migration and invasion in a dose-dependent manner. Furthermore, resveratrol could exhibit anti-GC effect by regulating FOS and MMP9 expression.
CONCLUSION
The anti-GC effects of resveratrol are related to the inhibition of cell proliferation, migration, invasion and induction of cell cycle arrest and apoptosis by targeting FOS and MMP9.
PENGARUH MODEL PEMBELAJARAN EXPERIENTIAL LEARNING TERHADAP KEMAMPUAN MENELAAH POLA PENYAJIAN DAN KEBAHASAAN TEKS IKLAN OLEH SISWA KELAS VII SMP MIFTAHUSSALAM MEDAN
Authors: Arianto Arianto , Zahara Siti Fatimah , Wulandari Wina , Muliatik Sri 
Published: February 2024

Penenlitian ini adalah bertujuan untuk mengetahui kemampuan menelaah pola penyajian dan kebahasaan teks iklan melalui model pembelajaran experiential learning. Populasi siswa kelas VIII SMP Miftahussalam secara keseluruhan berjumlah 108 siswa tersebar 3 kelas. Untuk menentukan sampel, peneliti menggunakan teknik sampling random yaitu kelas yang terpilih VIII-A yang berjumlah 36 siswa sebagai kelas eksperimen dan VIII-C yang berjumlah 36 siswa sebagai kelas kontrol. Metode penelitian ini menggunakan metode eksperimen. Dalam penelitian ini, peneliti menggunakan instrument penelitian berupa tes essai. Berdasakan analisis data diperoleh kemampuan menelaah pola penyajian dan kebahasaan teks iklan kelompok eksperimen memperoleh nilai akhir di kategori baik sekali karena 15 siswa mendapatkan nilai antara 80-100 (41,67%), dan kelompok kontrol memperoleh nilai akhir di kategori baik sekali karena 14 siswa mendapatkan nilai antara 80-100 (38,89). Dari hasil penelitian ini dapat diketahui bahwa hipotesis terbukti, melalui uji t diperoleh thitung> ttabel atau 7,2>1,99.
PENGARUH LOCUS OF CONTROL TERHADAP KINERJA KARYAWAN PADA PT OKI PULP & PAPER MILLS DI KABUPATEN OGAN KOMERING ILIR
Authors: Andhika Ari , Septia Fitri , Ramadhayani Rulli , . Supriadi , . Ismandra 
Published: February 2024

ABSTRAK
Sumber daya manusia sangat memegang peranan penting dalam sebuah perusahaan karena dengan adanya sumber daya manusia yang berupa karyawan yang berkualitas maka pekerjaan yang ada akan diselesaikan oleh karyawan tepat waktu dan menjadikan target dan tujuan perusahaan akan tercapai, penelitian ini menganalisis dan melakukan pengamatan kepada salah satu perusahaan yang ada di Kabupaten Ogan Ilir yaitu PT. OKI Pulp & Paper Mill, dengan teknik analisis yang digunakan regresi linier sederhana dan kategori penelitian deskriptif kuantitatif dengan variabel Locus of Control sebagai variabel independent dan kinerja sebagai variabel dependent, hasil yang ditemukan yaitu ada pengaruh variabel bebas locus of control terhadap variabel terikat yaitu kinerja dengan angka R Square sebesar 0.175 dan tingkat signifikan sebesar 0.00 dan terbukti variabel locus of control mempunyai pengaruh terhadap kinerja karyawan di PT. OKI Pulp & Paper Mill yang berada di Kabupaten Ogan Komering Ilir Provinsi Sumatera Selatan.

Kata Kunci : Locus of control, Kinerja
PENGARUH PENGGUNAAN TEKNOLOGI INFORMASI DAN KOMPETENSI SDM TERHADAP KINERJA PEGAWAI KANTOR LURAH SUNGAI LILIN KECAMATAN SUNGAI LILIN
Authors: . Harsanudin , Suryani Ade Nia , Zubardi Laidy 
Published: February 2024

ABSTRAK
Penelitian ini bertujuan untuk menjelaskan apakah Pengaruh Pengunaan Teknologi Informasi Dan Kompetensi SDM Terhadap Kinerja Pegawai Kantor Lurah Sungai Lilin Kecamatan Sungai Lilin. Sampel menggunakan teknik Maholtra. Metode pengumpulan data yang digunakan adalah dengan memberikan kuesioner kepada pegawai kelurahan sungai lilin kecamatan sungai lilin. Data dianalisis dengan menggunakan Metode Kuantitatif yaitu menggunakan uji validitas, uji reliabilitas, uji asumsi klasik, analsis regresi, analsis korelasi, analisis determinasi dan uji t dengan bantuan software SPSS 20.0 for windows. Hasil penelitian menunjukkan Pengaruh Pengunaan Teknologi Informasi Dan Kompetensi SDM Terhadap Kinerja Pegawai Kantor Lurah Sungai Lilin Kecamatan Sungai Lilin. Koefesien teknologi informasi dan komptensi sdm bertanda positif menandakan hubungan yang searah, dengan kata lain teknologi informasi dan kompetensi sdm akan berpengaruh secara signifikan terhadap keputusan pembelian. Hubungan antara kualitas produk dan harga terhadap kinerja pegawai menunjukkan hubungan yang sanggat kuat (R=0,872). Koefisien determinasi atau angka R square adalah sebesar 0,760 yang artinya adalah 76,0% variabel kinerja pegawai dipengaruh oleh teknologi informasi dan kompetensi sdm.
Kata Kunci: Teknologi Informasi, Kompetensi SDM, Kinerja Pegawai
PENGARUH DISIPLIN KERJA DAN KOMPENSASI TERHADAP KINERJA BADAN KEPEGAWAIAN DAN PENGEMBANGAN SDM KABUPATEN MUSI BANYUASIN
Authors: Rakhmalina Ika , Tores Ropal , Supriyanto Feri 
Published: February 2024

ABSTRACT
The objectives of this study are 1) To determine the effect of work discipline on employee performance of the Musi Banyuasin District Personnel and Human Resources Development Agency. 2) To determine the effect of compensation on employee performance of the Musi Banyuasin District Personnel and Human Resources Development Agency. 3) To determine the effect of Work Discipline and Compensation simultaneously on Employee Performance of the Personnel and Human Resources Development Agency of Musi Banyuasin Regency. The population in this study was 41 people taken using the Slovin formula so that the research sample was obtained as many as 37 people. The results showed that from the calculation of F-count (8,752) > F-table (3.28) and t-count for variable X1, namely work discipline, was (2,780) and for variable X2, compensation was (2,419) > t table. (1,687). From the research results, the tcount for variable X1, namely work discipline, is 2,780 > from t table 1.687, so H0 is rejected and H1 is accepted, which means that there is an effect of work discipline on the employee performance of the Personnel and HR Development Agency of Musi Banyuasin Regency.
From the research results, the t value for variable X2, namely compensation, is 2.419 > from t table 1.687, then H0 is accepted and H1 is rejected, which means that the X2 variable affects the performance of employees in the Personnel and Human Resources Development Agency of Musi Banyuasin Regency. From the research results, the F-statistic is 8,752 because F-count is greater than F-table, which is 3.28 with a probability value of 0.001 which means that it is below the significance value of 0.05, so, H0 is rejected and H3 is accepted, which means the independent variable is discipline work and compensation simultaneously (together) have an influence on employee performance. It means that H0 is rejected and Ha is accepted, which means that there is an effect of work discipline (X1), compensation (X2) on employee performance (Y), both simultaneously and partially.
Keywords : Discipline of Work, Compensation, and Employee Performance.