bluuebunny/crossref_metadata_2025_split huggingface dataset:
Isolated photon production in association with a jet pair through next-to-next-to-leading order in QCD
Authors: Badger Simon , Czakon Michał , Hartanto Heribertus Bayu , Moodie Ryan , Peraro Tiziano , Poncelet Rene , Zoia Simone 
Published: October 2023

Abstract
In this work, we provide a comprehensive set of differential cross-section distributions for photon + di-jet production in proton-proton collisions with next-to-next-to-leading order precision in massless QCD. The event selection corresponds to recent measurements by the ATLAS collaboration. We observe an improved description of data in comparison to lower-order calculations in the case of observables that are expected to be well described by perturbation theory. The results also show better agreement with data than parton-shower-matched and multi-jet-merged predictions generated for the ATLAS analysis using the Sherpa Monte Carlo. A particular highlight of our study is the use of exact five-point two-loop virtual amplitudes. This is the first calculation of a complete two-to-three hadron-collider process at next-to-next-to-leading order in QCD that does not rely on the leading-colour approximation at two loops. We demonstrate, nevertheless, that the sub-leading-colour effects present in the infraredand ultraviolet-finite double-virtual contributions are negligible in view of the remaining scale uncertainties.
Complete analysis on QED corrections to Bq → τ+τ−
Authors: Huang Yong-Kang , Shen Yue-Long , Zhao Xue-Chen , Zhou Si-Hong 
Published: October 2023

Abstract
Motivated by a dynamical enhancement of the electromagnetic corrections by a power of ΛQCD/mb in Bd,s→ μ+μ− at next-to-leading order (NLO), we extend the QED factorization effects on the leptonic B meson decays with light muon leptons to tauonic final states, Bd,s→ τ+τ−, using soft-collinear effective theory (SCET). This extension is necessary owing to the appearance of the large τ mass, which will lead to different power counting in SCET and also different results. We provide a complete NLO electromagnetic corrections to Bd,s→ τ+τ−, which include hard functions and hard-collinear functions below the bottom quark mass scale μb. The power enhanced electromagnetic effects from hard-collinear contributions on Bd,s→ μ+μ− discussed before also exist in Bd,s→ τ+τ−. However the logarithm term arising from contributions of hard-collinear photon and lepton virtualities for Bd,s→ τ+τ− is not large as it is in muon case due to the hard-collinear scale of τ mass, which lead to only approximately 0.04% QED corrections to the branching fraction of Bd,s→ τ+τ− compared with overall reduction about 0.5% in Bd,s→ μ+μ−.
Scalarized Kerr-Newman black holes
Authors: Guo Guangzhou , Wang Peng , Wu Houwen , Yang Haitang 
Published: October 2023

Abstract
In this paper, we construct scalarized rotating black holes within the framework of Einstein-Maxwell-scalar models. These models incorporate non-minimal couplings that can induce tachyonic instabilities, leading to the spontaneous scalarization of Kerr-Newman (KN) black holes. By exploring the domain of existence, we observe that the presence of scalarized KN black holes is suppressed by the black hole spin, with a maximum spin threshold beyond which scalarized solutions cease to exist. Intriguingly, we find that in specific parameter regimes, scalarized KN black holes can exhibit the presence of two unstable and one stable light rings on the equatorial plane, manifesting in both prograde and retrograde directions.
Tree-level Unitarity in $$ \textrm{SU}{(2)}_L\times \textrm{U}{(1)}_Y\times \textrm{U}{(1)}_{Y^{\prime }} $$ Models
Authors: Bento Miguel P. , Haber Howard E. , Silva João P. 
Published: October 2023

Abstract
In models with a U(1) gauge extension beyond the Standard Model, one can derive sum rules for the couplings of the theory that are a consequence of tree-level unitarity. In this paper, we provide a comprehensive list of coupling sum rules for a general $$ \textrm{SU}{(2)}_L\times \textrm{U}{(1)}_Y\times \textrm{U}{(1)}_{Y^{\prime }} $$
SU

2

L

×
U

1

Y

×
U

1

Y
′

gauge theory coupled to an arbitrary set of fermion and scalar multiplets. These results are of particular interest for models of dark matter that employ an extended gauge sector mediated by a new (dark) Z′ gauge boson. For the case of a minimal extension of the Standard Model with a $$ \textrm{U}{(1)}_{Y^{\prime }} $$
U

1

Y
′

gauge boson, we clarify the definitions of the weak mixing angle and the electroweak ρ parameter. We demonstrate the utility of a generalized ρ parameter (denoted by ρ′) whose definition naturally follows from the unitarity sum rules developed in this paper.
Improvement of Neurovascular Imaging Using Ultra-High-Resolution Computed Tomography Angiography
Authors: Ucar Felix A. , Frenzel Marius , Kronfeld Andrea , Altmann Sebastian , Sanner Antoine P. , Mercado Mario Alberto Abello , Uphaus Timo , Brockmann Marc A. , Othman Ahmed E. 
Published: October 2023

Abstract
Objective
To evaluate diagnostic image quality of ultra-high-resolution computed tomography angiography (UHR-CTA) in neurovascular imaging as compared to normal resolution CT-angiography (NR-CTA).

Material and Methods
In this retrospective single-center study brain and neck CT-angiography was performed using an ultra-high-resolution computed tomography scanner (n = 82) or a normal resolution CT scanner (NR-CTA; n = 73). Ultra-high-resolution images were reconstructed with a 1024 × 1024 matrix and a slice thickness of 0.25 mm, whereas NR-CT images were reconstructed with a 512 × 512 matrix and a slice thickness of 0.5 mm. Three blinded neuroradiologists assessed overall image quality, artifacts, image noise, overall contrast and diagnostic confidence using a 4-point Likert scale. Furthermore, the visualization and delineation of supra-aortic arteries with an emphasis on the visualization of small intracerebral vessels was assessed using a cerebral vascular score, also utilizing a 4-point Likert scale. Quantitative analyses included signal-to-noise ratio (SNR), contrast-to-noise ratio (CNR), noise and the steepness of gray value transition. Radiation exposure was determined by comparison of computed tomography dose index (CTDIvol), dose length product (DLP) and mean effective dose. Interrater agreement was evaluated via determining Fleiss-Kappa.

Results
Ultra-high-resolution CT-angiography (UHR-CTA) yielded excellent image quality with superior quantitative (SNR: p < 0.001, CNR: p < 0.001, steepness of gray value transition: p < 0.001) and qualitative results (overall image quality: 4 (Inter quartile range (IQR) = 4–4); p < 0.001, diagnostic confidence: 4 (IQR = 4–4); p < 0.001) compared to NR-CT (overall image quality: 3 (IQR = 3–3), diagnostic confidence: 3 (IQR = 3–4)). Furthermore, UHR-CT enabled significantly superior delineation and visualization of all vascular segments, from proximal extracranial vessels to the smallest peripheral cerebral branches (e.g., UHR-CTA PICA: 4 (3–4) vs. NR-CTA PICA: 3 (2–3); UHR-CTA P4: 4 (IQR = 3–4) vs. NR-CTA P4: 2 (IQR = 2–3); UHR-CTA M4: 4 (IQR = 4–4) vs. NR-CTA M4: 3 (IQR = 2–3); UHR-CTA A4: 4 (IQR = 3–4) vs. NR-CTA A4: 2 (IQR = 2–3); all p < 0.001). Noteworthy, a reduced mean effective dose was observed when applying UHR-CT (NR-CTA: 1.8 ± 0.3 mSv; UHR-CTA: 1.5 ± 0.5 mSv; p < 0.001).

Conclusion
Ultra-high-resolution CT-angiography improves image quality in neurovascular imaging allowing the depiction and evaluation of small peripheral cerebral arteries. It may thus improve the detection of pathologies in small cerebrovascular lesions and the resulting diagnosis.
Akutes Abdomen – seltene Ursache bei einer 80-jährigen Patientin unter immunsuppressiver Therapie
Authors: Schlottmann J. , Miller S. , Scheurig-Münkler C. , Merkl C. , Weber T. , Eser S. , Fuchs A. , Messmann H. , Probst A. 
Published: October 2023

ZusammenfassungEine 80-jährige Frau stellte sich zur Abklärung abdomineller Schmerzen vor. Vorausgegangen war die Diagnosestellung einer Autoimmunhepatitis mit Einleitung einer immunsuppressiven Therapie und Auftritt zweier Pneumonien mit opportunistischen Erregern. Die Bildgebung erbrachte einen „omental cake“ mit Verdacht auf Peritonealkarzinose. Bei Auftritt eines akuten Abdomens erfolgte eine explorative Laparotomie, hierbei zeigten sich intraabdominelle Abszesse. Anhand von Blutkulturen und des intraoperativ gewonnenen Materials wurde eine disseminierte Nocardiose diagnostiziert. Die Patientin verstarb aufgrund einer fulminant verlaufenen Sepsis.
Short-term disengagement from early intervention service for first-episode psychosis: findings from the “Parma Early Psychosis” program
Authors: Pelizza Lorenzo , Leuci Emanuela , Quattrone Emanuela , Azzali Silvia , Pupo Simona , Paulillo Giuseppina , Pellegrini Pietro , Menchetti Marco 
Published: October 2023

Abstract
Purpose
Service disengagement is a major concern for “Early Intervention in Psychosis” (EIP). Indeed, identifying predictors of engagement is crucial to maximize mental healthcare interventions in first-episode psychosis (FEP). No Italian study on this topic has been reported to date. Thus, the aims of this investigation were: (1) to examine short-term disengagement rate in an Italian population of FEP patients treated within an EIP service across a 1-year follow-up period, and (b) to assess the most relevant predictors of disengagement in the first year of treatment.

Methods
All participants were young FEP help-seeking patients, aged 12–35 years, enrolled within the “Parma Early Psychosis” (Pr-EP) protocol. At baseline, they completed the Positive And Negative Syndrome Scale (PANSS), the Health of the Nation Outcome Scale (HoNOS) and the Global Assessment of Functioning (GAF) scale. Univariate and multivariate Cox regression analyses were used.

Results
496 FEP individuals were enrolled in this research. Across the follow-up, a 16.5% prevalence of short-term disengagement was found. Particularly robust predictors of service disengagement were poor baseline treatment non-adherence, living with parents and the presence of brief psychotic disorder or schizophreniform disorder at entry.

Conclusion
About 16% of FEP patients disengaged the Pr-EP program within the first year of treatment. A solution to reduce disengagement and/or to favor re-engagement of these subjects might be to remain on EIP program caseloads allowing the option for low-intensity support and monitoring, also via remote technology.
Online consent: how much do we need to know?
Authors: Chomanski Bartlomiej , Lauwaert Lode 
Published: October 2023

AbstractThis paper argues, against the prevailing view, that consent to privacy policies that regular internet users usually give is largely unproblematic from the moral point of view. To substantiate this claim, we rely on the idea of the right not to know (RNTK), as developed by bioethicists. Defenders of the RNTK in bioethical literature on informed consent claim that patients generally have the right to refuse medically relevant information. In this article we extend the application of the RNTK to online privacy. We then argue that if internet users can be thought of as exercising their RNTK before consenting to privacy policies, their consent ought to be considered free of the standard charges leveled against it by critics.
Diversity of hydrodynamic radii of intrinsically disordered proteins
Authors: Białobrzewski Michał K. , Klepka Barbara P. , Michaś Agnieszka , Cieplak-Rotowska Maja K. , Staszałek Zuzanna , Niedźwiecka Anna 
Published: October 2023

AbstractIntrinsically disordered proteins (IDPs) form an important class of biomolecules regulating biological processes in higher organisms. The lack of a fixed spatial structure facilitates them to perform their regulatory functions and allows the efficiency of biochemical reactions to be controlled by temperature and the cellular environment. From the biophysical point of view, IDPs are biopolymers with a broad configuration state space and their actual conformation depends on non-covalent interactions of its amino acid side chain groups at given temperature and chemical conditions. Thus, the hydrodynamic radius (Rh) of an IDP of a given polymer length (N) is a sequence- and environment-dependent variable. We have reviewed the literature values of hydrodynamic radii of IDPs determined experimentally by SEC, AUC, PFG NMR, DLS, and FCS, and complement them with our FCS results obtained for a series of protein fragments involved in the regulation of human gene expression. The data collected herein show that the values of hydrodynamic radii of IDPs can span the full space between the folded globular and denatured proteins in the Rh(N) diagram.
Development of flavivirus subviral particles with low cross-reactivity by mutations of a distinct antigenic domain
Authors: Tabata Koshiro , Itakura Yukari , Ariizumi Takuma , Igarashi Manabu , Kobayashi Hiroko , Intaruck Kittiya , Kishimoto Mai , Kobayashi Shintaro , Hall William W. , Sasaki Michihito , Sawa Hirofumi , Orba Yasuko 
Published: October 2023

Abstract
The most conserved fusion loop (FL) domain present in the flavivirus envelope protein has been reported as a dominant epitope for cross-reactive antibodies to mosquito-borne flaviviruses (MBFVs). As a result, establishing accurate serodiagnosis for MBFV infections has been difficult as anti-FL antibodies are induced by both natural infection and following vaccination. In this study, we modified the most conserved FL domain to overcome this cross-reactivity. We showed that the FL domain of lineage I insect-specific flavivirus (ISFV) has differences in antigenicity from those of MBFVs and lineage II ISFV and determined the key amino acid residues (G106, L107, or F108), which contribute to the antigenic difference. These mutations were subsequently introduced into subviral particles (SVPs) of dengue virus type 2 (DENV2), Zika virus (ZIKV), Japanese encephalitis virus (JEV), and West Nile virus (WNV). In indirect enzyme-linked immunosorbent assays (ELISAs), these SVP mutants when used as antigens reduced the binding of cross-reactive IgG and total Ig induced by infection of ZIKV, JEV, and WNV in mice and enabled the sensitive detection of virus-specific antibodies. Furthermore, immunization of ZIKV or JEV SVP mutants provoked the production of antibodies with lower cross-reactivity to heterologous MBFV antigens compared to immunization with the wild-type SVPs in mice. This study highlights the effectiveness of introducing mutations in the FL domain in MBFV SVPs with lineage I ISFV-derived amino acids to produce SVP antigens with low cross-reactivity and demonstrates an improvement in the accuracy of indirect ELISA-based serodiagnosis for MBFV infections.

Key points
• The FL domain of Lineage I ISFV has a different antigenicity from that of MBFVs.
• Mutated SVPs reduce the binding of cross-reactive antibodies in indirect ELISAs.
• Inoculation of mutated SVPs induces antibodies with low cross-reactivity.
Decoding tumor stage by peritumoral and intratumoral radiomics in resectable esophageal squamous cell carcinoma
Authors: Tan Xian-Zheng , Ma Rong , Liu Peng , Xiao Chang-Hui , Zhang Hui-Hui , Yang Fan , Liang Chang-Hong , Liu Zai-Yi 
Published: October 2023

Abstract
Purpose
To evaluate the potential application of radiomics in predicting Tumor-Node-Metastasis (TNM) stage in patients with resectable esophageal squamous cell carcinoma (ESCC).

Methods
This retrospective study included 122 consecutive patients (mean age, 57 years; 27 women). Corresponding tumor of interest was identified on axial arterial-phase CT images with manual annotation. Radiomics features were extracted from intra- and peritumoral regions. Features were pruned to train LASSO regression model with 93 patients to construct a radiomics signature, whose performance was validated in a test set of 29 patients. Prognostic value of radiomics-predicted TNM stage was estimated by survival analysis in the entire cohort.

Results
The radiomics signature incorporating one intratumoral and four peritumoral features was significantly associated with TNM stage. This signature discriminated tumor stage with an area under curve (AUC) of 0.823 in the training set, with similar performance in the test set (AUC 0.813). Recurrence-free survival (RFS) was significantly different between different radiomics-predicted TNM stage groups (Low-risk vs high-risk, log-rank P = 0.004). Univariate and multivariate Cox regression analyses revealed that radiomics-predicted TNM stage was an independent preoperative factor for RFS.

Conclusions
The proposed radiomics signature combing intratumoral and peritumoral features was predictive of TNM stage and associated with prognostication in ESCC.

Graphical abstract
Modelling DTPA therapy following Am contamination in rats
Authors: Kastl Manuel , Grémy Olivier , Lamart Stephanie , Giussani Augusto , Li Wei Bo , Hoeschen Christoph 
Published: October 2023

AbstractA major challenge in modelling the decorporation of actinides (An), such as americium (Am), with DTPA (diethylenetriaminepentaacetic acid) is the fact that standard biokinetic models become inadequate for assessing radionuclide intake and estimating the resulting dose, as DTPA perturbs the regular biokinetics of the radionuclide. At present, most attempts existing in the literature are empirical and developed mainly for the interpretation of one or a limited number of specific incorporation cases. Recently, several approaches have been presented with the aim of developing a generic model, one of which reported the unperturbed biokinetics of plutonium (Pu), the chelation process and the behaviour of the chelated compound An–DTPA with a single model structure. The aim of the approach described in this present work is the development of a generic model that is able to describe the biokinetics of Am, DTPA and the chelate Am–DTPA simultaneously. Since accidental intakes in humans present many unknowns and large uncertainties, data from controlled studies in animals were used. In these studies, different amounts of DTPA were administered at different times after contamination with known quantities of Am. To account for the enhancement of faecal excretion and reduction in liver retention, DTPA is assumed to chelate Am not only in extracellular fluids, but also in hepatocytes. A good agreement was found between the predictions of the proposed model and the experimental results for urinary and faecal excretion and accumulation and retention in the liver. However, the decorporation from the skeletal compartment could not be reproduced satisfactorily under these simple assumptions.
Deformed Graphical Zonotopes
Authors: Padrol Arnau , Pilaud Vincent , Poullot Germain 
Published: October 2023

Abstract
We study deformations of graphical zonotopes. Deformations of the classical permutahedron (which is the graphical zonotope of the complete graph) have been intensively studied in recent years under the name of generalized permutahedra. We provide an irredundant description of the deformation cone of the graphical zonotope associated to a graph G, consisting of independent equations defining its linear span (in terms of non-cliques of G) and of the inequalities defining its facets (in terms of common neighbors of neighbors in G). In particular, we deduce that the faces of the standard simplex corresponding to induced cliques in G form a linear basis of the deformation cone, and that the deformation cone is simplicial if and only if G is triangle-free.
Cashing out crypto: state of practice in ransom payments
Authors: Patsakis Constantinos , Politou Eugenia , Alepis Efthimios , Hernandez-Castro Julio 
Published: October 2023

AbstractThe fast pace of blockchain technology and cryptocurrencies’ evolution makes people vulnerable to financial fraud and provides a relatively straightforward monetisation mechanism for cybercriminals, in particular ransomware groups which exploit crypto’s pseudo-anonymity properties. At the same time, regulatory efforts for addressing crimes related to crypto assets are emerging worldwide. In this work, we shed light on the current state of practice of ransomware monetisation to provide evidence of their payment traceability, explore future trends, and—above all—showcase that over-regulating cryptocurrencies is not the best way to mitigate their risks. For that purpose, first, we provide an overview of the legislative initiatives currently taken by the USA, the EU, and the OECD to regulate cryptocurrencies, showing that strict laws and the divergences between the regulatory regimes can hardly efficiently regulate the global phenomenon of cryptocurrency, which transcends borders and states. Next, we focus on illicit payments in bitcoin to ransomware groups, illustrating how these payments are siphoned off and how criminals cash out the ransom, often leaving traceable evidence behind. To this end, we leverage a publicly available dataset and a set of state-of-the-art blockchain analysis tools to identify payment patterns, trends, and transaction trails, which are provided in an anonymised form. Our work reveals that a significant amount of illicit bitcoin transactions can be easily traced, and consequently, many cyber crimes like ransomware can actually be tracked down and investigated with existing tools and laws, thus providing fertile ground for better and fairer legislation on crypto.
Clinical effect of progressive pulmonary fibrosis on patients with connective tissue disease-associated interstitial lung disease: a single center retrospective cohort study
Authors: Lee Ju Kwang , Ahn Yura , Noh Han Na , Lee Sang Min , Yoo Bin , Lee Chang-Keun , Kim Yong-Gil , Hong Seokchan , Ahn Soo Min , Kim Ho Cheol 
Published: October 2023

AbstractThe concept of progressive pulmonary fibrosis (PPF) has been introduced to predict the diverse prognosis of interstitial lung disease (ILD). However, the incidence and effect of PPF on outcomes in patients with connective tissue disease-associated interstitial lung disease (CTD-ILD) need to be elucidated. This study reviewed 197 patients with CTD-ILD. Symptomatic worsening, pulmonary function decline, and radiological deterioration were investigated to assess the fulfillment of PPF diagnostic criteria. Clinical outcomes, including mortality, were compared based on the presence or absence of PPF. The median follow-up duration was 17.4 months. The mean age of the patients was 64.0 years, and 60.9% were female. Among the underlying CTDs, rheumatoid arthritis (42.1%), inflammatory myositis (19.8%), and systemic sclerosis (13.2%) were the most common. Of the 197 patients, 37 (18.8%) met the diagnostic criteria for PPF during the follow-up period. Even after adjusting for other significant risk factors, PPF was independently associated with mortality [hazard ratio (HR) 3.856; 95% confidence interval (CI) 1.387–10.715; P = 0.010] and baseline albumin was marginally significantly associated with mortality (HR 0.549; CI 0.298–1.010; P = 0.054). The median survival was also significantly shorter in the PPF group than in the non-PPF group (72.3 ± 12.9 vs. 126.8 ± 15.5 months, P < 0.001). Baseline KL-6 ≥ 1000 (U/mL) was a significant risk factor for PPF (HR 2.885; CI 1.165–7.144; P = 0.022). In addition to increased mortality, the PPF group had significantly higher rates of respiratory-related hospitalizations, pneumonia, acute exacerbations, and weight loss than the non-PPF group. PPF is a significant prognostic indicator in patients with CTD-ILD. Thus, healthcare professionals should know that patients with CTD-ILD are at risk of PPF.