bluuebunny/crossref_metadata_2025_split huggingface dataset:
Factor structure of academic resilience among Polish and Ukrainian students involved in remote education caused by Covid-19 and military aggression
Authors: Matusevych Tetiana , Demeshkant Nataliia , Trusz Sławomir 
Published: January 2024

AbstractAcademic resilience explains how students overcome various challenges or negative experiences that can hinder the learning process. The COVID pandemic as well as war conflicts might be significant factors affecting the structure of the academic resilience of students. This study attempted to assess the extent to which the Cassidy’s construct of resilience can be used to interpret the behavior of other—Polish and Ukrainian samples, under remote education caused by the COVID-19 pandemic and Russian military aggression against the Ukrainian civils. Second, the relationships between resilience and students' self-efficacy were estimated. To test the factor structure of the resilience exploratory and confirmatory factor analyses were conducted. Assumed structure reproduced to a greater extent among Polish (83.4% similarity) than in Ukrainian respondents (from 27 to 40%) and it was three or two factors for Polish and Ukrainian students, respectively. General self-efficacy positively correlated with resilience both among Polish and Ukrainian respondents confirming the concurrent validity of the scale. The discovered differences were explained by differences in the historical and sociocultural experiences of the two nations. If among Ukrainian students historical and social experiences actually lead to the formation of a pattern of Perseverance in Overcoming Problems, then in the factor analysis, this pattern should be reproduced in the form of a single factor. At the same time, experiences with negative emotions should give a second-factor Negative affect and emotional response. The results obtained confirmed this assumption.
Migraine is associated with the development of adult patients with inflammatory bowel disease: a nationwide, population-based study
Authors: Lee Chan Hyung , Han Kyungdo , Lee Hyun Jung , Yu Hosun , Kim Seulji , Choi Kookhwan , Koh Seong-Joon , Im Jong Pil , Kim Joo Sung 
Published: January 2024

AbstractIt has been reported that migraine is more common in patients with inflammatory bowel disease (IBD) than in general. However, the impact of migraine on the development of IBD has not yet been elucidated. The aim of this study was to determine the association between migraine and the development of IBD. This nationwide population-based cohort study was conducted using the Korean National Health Insurance Service (NHIS) database. A total of 10,628,070 people aged 20 years or older who had undergone a national health examination conducted by the NHIS in 2009 were followed up until 2017. The study population was divided into two groups according to the presence or absence of migraine. We analyzed the incidence of newly developed IBD, Crohn’s disease (CD), or ulcerative colitis (UC) during the follow-up period. The incidence of IBD was significantly higher in patients with migraine (adjusted hazard ratio [aHR] with 95% confidence interval [95%CI] of 1.31 [1.173–1.468], p < 0.001), CD (aHR with 95%CI of 1.58 [1.237–2.013], p < 0.001) and UC (aHR with 95%CI of 1.26 [1.106–1.424], p < 0.001) than in those without migraine. After 5 years of follow-up, those with migraine showed curves implying cumulative incidences of IBD with a steep increase, especially for CD. In subgroup analysis, migraine was associated with the risk of UC in males (aHR, 1.431 vs. 1.117; interaction p = 0.042). Migraine is significantly associated with the development of IBD. Patients with migraine should be monitored carefully for the development of IBD.
Molecular cloning, subcellular localization, and rapid recruitment to DNA damage sites of chicken Ku70
Authors: Koike Manabu , Yamashita Hideji , Yutoku Yasutomo , Koike Aki 
Published: January 2024

AbstractKu70 is a multifunctional protein with pivotal roles in DNA repair via non-homologous end-joining, V(D)J recombination, telomere maintenance, and neuronal apoptosis control. Nonetheless, its regulatory mechanisms remain elusive. Chicken Ku70 (GdKu70) cDNA has been previously cloned, and DT40 cells expressing it have significantly contributed to critical biological discoveries. GdKu70 features an additional 18 amino acids at its N-terminus compared to mammalian Ku70, the biological significance of which remains uncertain. Here, we show that the 5′ flanking sequence of GdKu70 cDNA is not nearly encoded in the chicken genome. Notably, these 18 amino acids result from fusion events involving the NFE2L1 gene on chromosome 27 and the Ku70 gene on chromosome 1. Through experiments using newly cloned chicken Ku70 cDNA and specific antibodies, we demonstrated that Ku70 localizes within the cell nucleus as a heterodimer with Ku80 and promptly accumulates at DNA damage sites following injury. This suggests that the functions and spatiotemporal regulatory mechanisms of Ku70 in chickens closely resemble those in mammals. The insights and resources acquired will contribute to elucidate the various mechanisms by which Ku functions. Meanwhile, caution is advised when interpreting the previous numerous key studies that relied on GdKu70 cDNA and its expressing cells.
Prediction of properties of boron $$\alpha$$-icosahedral nanosheet by bond-addictive $${\mathbb {M}}$$-polynomial
Authors: Xavier D. Antony , Julietraja K. , Alsinai Ammar , Akhila S. 
Published: January 2024

AbstractNanosheets with boron elements have excellent characteristics which makes the boron polymorphs unique and super hard. A boron $$\alpha$$
α
-icosahedral nanosheet in crystalline form has superconductivity and thermal electronic properties. In theoretical chemistry and QSPR/QSAR study, a topological descriptor is an important analytical tool. It helps to analyse the structure and its properties and also correlates the with numerical expressions. The valence-based M-polynomial provides quantitative measures of molecular properties based on their geometric, electrostatic, and quantum chemical characteristics. In this article, the QSPR/QSAR analysis is performed for this nanosheet and the analytical expressions are validated with original synthesized data, and received excellent correlation values of 0.9835 and 0.9932. The mathematical expression of the structure is analysed and the indices are compared graphically and numerically.
Lower body negative pressure identifies altered central vein characteristics without accompanying changes to baroreflexes in astronauts within hours of landing
Authors: Mastrandrea C. J. , Greaves D. K. , Shoemaker J. K. , Blaber A. P. , Arbeille P. , Hughson R. L. 
Published: January 2024

AbstractCardiovascular deconditioning and altered baroreflexes predispose returning astronauts to Orthostatic Intolerance. We assessed 7 astronauts (1 female) before and following long-duration spaceflight (146 ± 43 days) with minimal upright posture prior to testing. We applied lower body negative pressure (LBNP) of up to − 30 mmHg to supine astronauts instrumented for continual synchronous measurements of cardiovascular variables, and intermittent imaging the Portal Vein (PV) and Inferior Vena Cava (IVC). During supine rest without LBNP, postflight elevations to total peripheral resistance (TPR; 15.8 ± 4.6 vs. 20.8 ± 7.1 mmHg min/l, p < 0.05) and reductions in stroke volume (SV; 104.4 ± 16.7 vs. 87.4 ± 11.5 ml, p < 0.05) were unaccompanied by changes to heart rate (HR) or estimated central venous pressure (CVP). Small increases to systolic blood pressure (SBP) and diastolic blood pressure (DBP) were not statistically significant. Autoregressive moving average modelling (ARMA) during LBNP did not identify differences to either arterial (DBP → TPR and SBP → HR) or cardiopulmonary (CVP → TPR) baroreflexes consistent with intact cardiovascular control. On the other hand, IVC and PV diameter-CVP relationships during LBNP revealed smaller diameter for a given CVP postflight consistent with altered postflight venous wall dynamics.
Early involvement of peripherally derived monocytes in inflammation in an NMO-like mouse model
Authors: Kim Moonhang , Kim Won Seok , Cha Hyeuk , Kim Boram , Kwon Young Nam , Kim Sung Min 
Published: January 2024

AbstractNeuromyelitis optica (NMO) is an autoimmune inflammatory disease that primarily affects the optic nerve and spinal cord within the central nervous system (CNS). Acute astrocyte injury caused by autoantibodies against aquaporin 4 (NMO-IgG) is a well-established key factor in the pathogenesis, ultimately leading to neuronal damage and patient disability. In addition to these humoral immune processes, numerous innate immune cells were found in the acute lesions of NMO patients. However, the origin and function of these innate immune cells remain unclear in NMO pathogenesis. Therefore, this study aims to analyze the origin and functions of these innate immune cells in an NMO-like mouse model and evaluate their role in the pathophysiology of NMO. The expression of Tmem119 on Iba1 + cells in brain tissue disappeared immediately after the injection of NMO-IgG + human complement mixture, while the expression of P2ry12 remained well-maintained at 1 day after injection. Based on these observations, it was demonstrated that monocytes infiltrate the brain during the early stages of the pathological process and are closely associated with the inflammatory response through the expression of the proinflammatory cytokine IL-1β. Understanding the variations in the expression patterns of P2ry12, Tmem119, and other markers could be helpful in distinguishing between these cell types and further analyzing their functions. Therefore, this research may contribute to a better understanding of the mechanisms and potential treatments for NMO.
Measurement accuracy of the acetabular cup position using an inertial portable hip navigation system with patients in the lateral decubitus position
Authors: Tanino Hiromasa , Mitsutake Ryo , Ito Hiroshi 
Published: January 2024

AbstractAccurate cup placement is critical to ensure satisfactory outcomes after total hip arthroplasty. Portable hip navigation systems are novel intraoperative guidance tools that achieve accurate cup placement in the supine position; however, accuracy in the lateral decubitus position is under debate. A new inertial portable navigation system has recently become available. The present study investigated the accuracy of measurements of the cup position in 54 patients in the lateral decubitus position using this system and compared it with that by a goniometer. After cup placement, cup abduction and anteversion were measured using the system and by the goniometer, and were then compared with postoperatively measured angles. Absolute measurement errors with the system were 2.8° ± 2.6° for cup abduction and 3.9° ± 2.9° for anteversion. The system achieved 98 and 96% measurement accuracies within 10° for cup abduction and anteversion, respectively. The system was more accurate than the goniometer for cup anteversion (p < 0.001), but not for abduction (p = 0.537). The system uses a new registration method of the pelvic reference plane and corrects intraoperative pelvic motion errors, which may affect measurement accuracy. In the present study, reliable and reproducible intraoperative measurements of the cup position were obtained using the inertial portable navigation system.
Support from parents, teachers, and peers and the moderation of subjective and objective stress of secondary school student
Authors: Hoferichter Frances , Lohilahti Jonne , Hufenbach Miriam , Grabe Hans Jörgen , Hageman Geja , Raufelder Diana 
Published: January 2024

AbstractDuring adolescence, students increasingly report suffering from stress and school burnout, which poses a risk to students’ healthy development. However, social support may counteract perceived stress according to the Buffering Hypothesis and the Conservation of Resources Theory. In search of factors that would support healthy student development, studies have primarily focused on self-report data and neglected biophysiological processes. Addressing this research desideratum, this study examined whether perceived social support buffers the interplay of self-reported stress considering biophysiological markers (i.e., cortisol, alpha-amylase, oxidative stress, and telomere length). 83 secondary school students (Mage = 13.72, SD = 0.67; 48% girls) from Germany participated in a questionnaire study and biophysiological testing. Moderation analyses in R revealed that support from parents moderated the relationships between psychological stress as well as cynicism and inadequacy at school linked to alpha-amylase.
Tetracycline removal from wastewater via g-C3N4 loaded RSM-CCD-optimised hybrid photocatalytic membrane reactor
Authors: Esfandiaribayat Milad , Binazadeh Mojtaba , Sabbaghi Samad , Mohammadi Milad , Ghaedi Samaneh , Rajabi Hamid 
Published: January 2024

AbstractIn this study, a split-type photocatalytic membrane reactor (PMR), incorporating suspended graphitic carbon nitride (g-C3N4) as photocatalyst and a layered polymeric composite (using polyamide, polyethersulfone and polysulfone polymers) as a membrane was fabricated to remove tetracycline (TC) from aqueous solutions as the world's second most used and discharged antibiotic in wastewater. The photocatalyst was synthesised from melamine by ultrasonic-assisted thermal polymerisation method and, along with the membrane, was characterised using various methods, including Brunauer–Emmett–Teller analysis (BET), Fourier-transform infrared spectroscopy (FTIR), X-ray diffraction analysis (XRD), Field emission scanning electron microscopy (FESEM), and Ultraviolet–visible spectroscopy (UV–Vis). The PMR process was optimised, using Design-Expert software for tetracycline removal in terms of UV irradiation time, pH, photocatalyst loading, tetracycline concentration, and membrane separation iteration. It was revealed that a membrane-integrated reactor as a sustainable system could effectively produce clean water by simultaneous removal of tetracycline and photocatalyst from aqueous solution. The maximum removal of 94.8% was obtained at the tetracycline concentration of 22.16 ppm, pH of 9.78 with 0.56 g/L of photocatalyst in the irradiation time of 113.77 min after six times of passing membrane. The PMR system showed reasonable reusability by about a 25.8% drop in TC removal efficiency after seven cycles at optimal conditions. The outcomes demonstrate the promising performance of the proposed PMR system in tetracycline removal from water and suggest that it can be scaled as an effective approach for a sustainable supply of antibiotic-free clean water.
Prediction of BiS2-type pnictogen dichalcogenide monolayers for optoelectronics
Authors: Mella José D. , Nalabothula Muralidhar , Muñoz Francisco , Rabe Karin M. , Wirtz Ludger , Singh Sobhit , Romero Aldo H. 
Published: January 2024

AbstractIn this work, we introduce a 2D materials family with chemical formula MX2 (M={As, Sb, Bi} and X={S, Se, Te}) having a rectangular 2D lattice. This materials family has been predicted by systematic ab-initio structure search calculations in two dimensions. Using density-functional theory and many-body perturbation theory, we study the structural, vibrational, electronic, optical, and excitonic properties of the predicted MX2 family. Our calculations reveal that the predicted SbX2 and BiX2 monolayers are stable while the AsX2 layers exhibit an in-plane ferroelectric instability. All materials display strong excitonic effects and good optical absorption within the infrared-to-visible range. Hence, these monolayers can harvest solar energy and serve in optoelectronics applications. Furthermore, our results indicate that exfoliation of the predicted MX2 monolayers from their bulk counterparts is experimentally viable.
Pushed to extremes: distinct effects of high temperature versus pressure on the structure of STEP
Authors: Guerrero Liliana , Ebrahim Ali , Riley Blake T. , Kim Minyoung , Huang Qingqiu , Finke Aaron D. , Keedy Daniel A. 
Published: January 2024

AbstractProtein function hinges on small shifts of three-dimensional structure. Elevating temperature or pressure may provide experimentally accessible insights into such shifts, but the effects of these distinct perturbations on protein structures have not been compared in atomic detail. To quantitatively explore these two axes, we report the first pair of structures at physiological temperature versus. high pressure for the same protein, STEP (PTPN5). We show that these perturbations have distinct and surprising effects on protein volume, patterns of ordered solvent, and local backbone and side-chain conformations. This includes interactions between key catalytic loops only at physiological temperature, and a distinct conformational ensemble for another active-site loop only at high pressure. Strikingly, in torsional space, physiological temperature shifts STEP toward previously reported active-like states, while high pressure shifts it toward a previously uncharted region. Altogether, our work indicates that temperature and pressure are complementary, powerful, fundamental macromolecular perturbations.
Benefits, costs and enabling conditions to achieve ‘water for all’ in rural and remote Australia
Authors: Manero Ana , Adamowicz Wiktor , Akter Sonia , Spencer-Cotton Alaya , Coombes Peter J. , Wyrwoll Paul , Horne James , Lansbury Nina , Creamer Sandra , Taylor Katherine Selena , Fanaian Safa , Grafton R. Quentin 
Published: January 2024

AbstractAustralia will not meet Sustainable Development Goal target 6.1, to “achieve universal and equitable access to safe and affordable drinking water for all” by 2030, unless water service provision is improved to hundreds of small (less than 10,000 residents), rural and remote (SRR) communities. We have estimated the national benefits of a programme to upgrade drinking water services to ensure ‘good quality’ for 395 Australian SRR communities using a stated preference survey of 3,523 participants reflective of the Australian population. Using multiple model estimates, we calculated the willingness to pay at between AU$324 and AU$847 per Australian household per year for 10 years. Aggregating across the relevant Australian population, we calculated the aggregate willingness to pay for water quality improvements at AU$1.2–4.7 billion yr−1, or AU$8.3–33.2 billion as a 10-year net present value. We further estimated the capital and operating costs to provide ‘good-quality’ drinking water in the 395 SRR communities under three scenarios; the costs range from AU$0.51 to AU$3.29 million per community and, in total, from AU$0.2 billion to AU$1.3 billion.
Ana1/CEP295 is an essential player in the centrosome maintenance program regulated by Polo kinase and the PCM
Authors: Pimenta-Marques Ana , Perestrelo Tania , Reis-Rodrigues Patricia , Duarte Paulo , Ferreira-Silva Ana , Lince-Faria Mariana , Bettencourt-Dias Mónica 
Published: January 2024

AbstractCentrioles are part of centrosomes and cilia, which are microtubule organising centres (MTOC) with diverse functions. Despite their stability, centrioles can disappear during differentiation, such as in oocytes, but little is known about the regulation of their structural integrity. Our previous research revealed that the pericentriolar material (PCM) that surrounds centrioles and its recruiter, Polo kinase, are downregulated in oogenesis and sufficient for maintaining both centrosome structural integrity and MTOC activity. We now show that the expression of specific components of the centriole cartwheel and wall, including ANA1/CEP295, is essential for maintaining centrosome integrity. We find that Polo kinase requires ANA1 to promote centriole stability in cultured cells and eggs. In addition, ANA1 expression prevents the loss of centrioles observed upon PCM-downregulation. However, the centrioles maintained by overexpressing and tethering ANA1 are inactive, unlike the MTOCs observed upon tethering Polo kinase. These findings demonstrate that several centriole components are needed to maintain centrosome structure. Our study also highlights that centrioles are more dynamic than previously believed, with their structural stability relying on the continuous expression of multiple components.
Immunosurveillance encounters cancer metabolism
Authors: Chuang Yu-Ming , Tzeng Sheue-Fen , Ho Ping-Chih , Tsai Chin-Hsien 
Published: January 2024

AbstractTumor cells reprogram nutrient acquisition and metabolic pathways to meet their energetic, biosynthetic, and redox demands. Similarly, metabolic processes in immune cells support host immunity against cancer and determine differentiation and fate of leukocytes. Thus, metabolic deregulation and imbalance in immune cells within the tumor microenvironment have been reported to drive immune evasion and to compromise therapeutic outcomes. Interestingly, emerging evidence indicates that anti-tumor immunity could modulate tumor heterogeneity, aggressiveness, and metabolic reprogramming, suggesting that immunosurveillance can instruct cancer progression in multiple dimensions. This review summarizes our current understanding of how metabolic crosstalk within tumors affects immunogenicity of tumor cells and promotes cancer progression. Furthermore, we explain how defects in the metabolic cascade can contribute to developing dysfunctional immune responses against cancers and discuss the contribution of immunosurveillance to these defects as a feedback mechanism. Finally, we highlight ongoing clinical trials and new therapeutic strategies targeting cellular metabolism in cancer.
Basal MET phosphorylation is an indicator of hepatocyte dysregulation in liver disease
Authors: Burbano de Lara Sebastian , Kemmer Svenja , Biermayer Ina , Feiler Svenja , Vlasov Artyom , D’Alessandro Lorenza A , Helm Barbara , Mölders Christina , Dieter Yannik , Ghallab Ahmed , Hengstler Jan G , Körner Christiane , Matz-Soja Madlen , Götz Christina , Damm Georg , Hoffmann Katrin , Seehofer Daniel , Berg Thomas , Schilling Marcel , Timmer Jens , Klingmüller Ursula 
Published: January 2024

AbstractChronic liver diseases are worldwide on the rise. Due to the rapidly increasing incidence, in particular in Western countries, metabolic dysfunction-associated steatotic liver disease (MASLD) is gaining importance as the disease can develop into hepatocellular carcinoma. Lipid accumulation in hepatocytes has been identified as the characteristic structural change in MASLD development, but molecular mechanisms responsible for disease progression remained unresolved. Here, we uncover in primary hepatocytes from a preclinical model fed with a Western diet (WD) an increased basal MET phosphorylation and a strong downregulation of the PI3K-AKT pathway. Dynamic pathway modeling of hepatocyte growth factor (HGF) signal transduction combined with global proteomics identifies that an elevated basal MET phosphorylation rate is the main driver of altered signaling leading to increased proliferation of WD-hepatocytes. Model-adaptation to patient-derived hepatocytes reveal patient-specific variability in basal MET phosphorylation, which correlates with patient outcome after liver surgery. Thus, dysregulated basal MET phosphorylation could be an indicator for the health status of the liver and thereby inform on the risk of a patient to suffer from liver failure after surgery.