bluuebunny/crossref_metadata_2025_split huggingface dataset:
The Right to a Life-Sustaining Climate System: Selected Case Law
Authors: Stoczkiewicz Marcin 
Published: December 2023

Abstract
This article analyses the legal discourse concerning the right to a life-sustaining climate system. The subject of analysis is the discourse around selected landmark cases in which arguments were raised about the need to protect a stable climate for the sake of protecting fundamental constitutional rights threatened by the climate crisis (Juliana v United States, Urgenda v Netherlands, Neubauer v Germany, and Hawai’i Electric Light Co.). The analysis is conducted from the point of view of the legal sources (applicable legal norms, clearly recognised constitutional rights) from which this unenumerated fundamental right is derived. This analysis allows us to assume that the right to a life-sustaining climate system is understood in legal discourse as: (i) a constitutional right derived from the right to life, liberty and property as necessary for their realisation, or (ii) a constitutional right encompassed by the right to a clean and healthy environment, or even as (iii) a constitutional right that is a predicate of all constitutional rights. In the author’s view, this right can also be understood as an unexpressed item (aspect) of the right to life.
Imagining and Reimagining Imagination via the Ontology of Imagination in Miki Kiyoshi
Authors: Krummel John W.M. 
Published: December 2023

Abstract
The paper explicates what the World War 2 era Japanese philosopher, Miki Kiyoshi, of the Kyoto School, called the logic of imagination and of forms as an ontology. I understand this ontology as ultimately an “anontology”, where novelty and creativity are predicated upon the pathos of singularity and contingency that Miki calls “the nothing” (mu). Its productive function that is technological vis-à-vis the environment involves an embodied praxis that Miki, borrowing the terms of his mentor, Nishida Kitarō, calls “enactive intuition”. This productivity unfolds the historical world, on the basis of that deep pathos within us in synthesis with logos, as what can be characterized as the auto-determination of the indeterminate. But the advance of technology today takes this unfolding of the world perhaps beyond what Miki anticipated with his self-professed humanism. To make these points, the paper, for the most part, focuses on the last and longest chapter in Miki’s Logic of Imagination, where Miki discusses and appropriates Kant’s concept of imagination and its schematism from both the first and third Critiques while also showing the influences of Heidegger along with Nishida. But the originality in Miki takes his philosophy of imagination beyond these predecessors while also raising questions as to the relationship between human beings and nature and to the very meaning of “nature” (shizen) in Miki. I will also discuss post-war theories of imagination and technology coming after Miki that respond to the more recent digitization and virtualization of the real.
A 37-Year-Old Schizophrenic Woman With Abdominal Pain
Authors: Liao Yiqun , Ma Yue , Chao Fei , Wang Yong , Zhao Ziming , Ren Jun 
Published: December 2023

Introduction: Internal fistula across the posterior wall of stomach and the transverse colon caused by foreign bodies in the alimentary tract presents an extremely rare medical entity. Presentation of case: We report an aschizophrenia female patient with onset of internal fistula across the posterior wall of stomach and the transverse colon triggered by swallowed magnetic metal beads. The patient was admitted to the emergency room of Northern Jiangsu People’s Hospital because of acute right lower abdominal pain. Emergency routine abdominal CT scan revealed acute appendicitis and a set of foreign body in digestive tract. Discussion: The foreign body in the stomach was removed by open surgery after tentative Endoscopic foreign body removal and laparoscopic appendectomy and exploration. In the process of exploring the gastric wall, it was found that one of magnet beads was embedded in the posterior wall of stomach and adhered to part of the transverse colon. After separation, it was found that an internal fistula was formed across the posterior wall of stomach and the transverse colon. As the patient ate only a small amount of food within 2 days, and the intestines were in good condition, we performed partial transverse colectomy, end-to-side anastomosis and gastric wall repair. Conclusion: This case shows that for long-term foreign bodies in the digestive tract, we should be beware of the onset of gastrointestinal perforation. Moreover, perforation caused by the force acting on a blunt foreign body often results in atypical imaging findings, and the diagnosis of perforation cannot be clearly determined by imaging findings such as the presence of free gas downstream of the diaphragm. This poses new challenges for clear diagnosis and treatment.
Serum Adiponectin and Leptin Among Ghanaian Migrants in Amsterdam and Their Compatriots in Rural and Urban Ghana: The RODAM Study
Authors: Kusi-Mensah Yaw A , Hayfron-Benjamin Charles , Chetty Sean , van der Linden Eva L , Meeks Karlijn AC , Beune Erik , Anokye-Danso Frederick , Ahima Rexford S , van den Born Bert-Jan , Agyemang Charles 
Published: December 2023

Background: The rapidly rising cardiometabolic disease (CMD) burden in urbanizing sub-Saharan African populations and among sub-Saharan African migrants in Europe likely affects serum adiponectin and leptin levels, but this has not yet been quantified. Objectives: To compare the serum levels of adiponectin and leptin among migrant, and non-migrant (urban and rural) populations of Ghanaian descent. Methods: Cross-sectional analysis of serum leptin and adiponectin in the multi-centre Research on Obesity and Diabetes among African Migrants (RODAM) study. Logistic-regression models were used to examine the association between these adipocyte-derived hormones after stratification (sex, geographic area) and adjustments for potential confounders. Results: A total of 2518 Ghanaians were included. Rural participants had the highest serum adiponectin and lowest leptin levels compared to Amsterdam and urban Ghanaians ( P < .001). In fully adjusted models, participants living in urban Ghana had significantly higher odds of hyperleptinemia compared to rural participants (women-odds ratio 2.88; 95% CI, 1.12-7.38, P = .028 and men 43.52, 95% CI, 4.84-391.25, P < .001). Urban Ghanaian men also had higher odds of elevated leptin: adiponectin ratio (6.29, 95% CI, 1.43-27.62, P = .015). The odds of hyperleptinemia were only higher in Amsterdam Ghanaian men (10.56; 95% CI, 1.11-100.85, P = .041), but not in women (0.85; 95% CI, 0.30-2.41, P = .759). There was no significant association between hypoadiponectinemia and geographical location in both sexes. Conclusion: Urbanization is associated with serum adiponectin and leptin levels after adjusting for confounding covariates in sub-Saharan Africans. These findings serve as a backdrop for further research on the role adipokines play in CMD epidemiology among Africans.
Intraoperative assessment of the curative potential to predict survival after gastric cancer resection: A national cohort study
Authors: Linder Gustav , McGregor Richard J. , Lindblad Mats 
Published: December 2023

Background: The surgeon’s intraoperative assessment of the curative potential of tumor resection following gastrectomy adds new information that could help clinicians and patients by predicting survival. Methods: All patients in Sweden undergoing gastric cancer resection between 2006 and 2018 were grouped according to a prospectively registered variable; the surgeon’s intraoperative assessment of the curative potential of surgery: curative, borderline curative, or palliative. Factors affecting group allocation were analyzed with multivariable logistic regression, while survival was analyzed using multivariable Cox regression and the Kaplan–Meier method. Positive predictive value (PPV) and negative predictive value (NPV) were calculated. Results: Of 2341 patients undergoing gastric cancer resection, 1547 (71%) were deemed curative, 340 (15%) borderline curative, and 314 (14%) palliative (140 missing assessments). Advanced stage increased the risk of borderline curative resection (Stage III, odds ratio (OR) = 6.04, 95% confidence interval (CI) = 3.92–9.31), as did emergency surgery OR = 3.31 (1.74–6.31) and blood loss >500 mL; OR = 1.63 (1.06–2.49). Neoadjuvant chemotherapy and multidisciplinary team (MDT) discussion both decreased the risk of borderline curative resection, OR = 0.58 (0.39–0.87) and 0.57 (0.40–0.80), respectively. In multivariable Cox regression, the surgeon’s assessment independently predicted worse survival for borderline curative (hazard ratio (HR) = 1.54, 95% CI = 1.29–1.83) and palliative resections (HR = 1.76, 95% CI = 1.45–2.19), compared to curative resections. The sensitivity of the surgeon’s assessment of long-term survival was 96.7%. The PPV was 50.7% and the NPV was 92.1%. Conclusion: The surgeon’s intraoperative assessment of the curative potential of gastric cancer surgery may independently aid survival prediction and is analogous to prognostication by pathologic Staging. Advanced disease, emergency surgery, and a high intraoperative blood loss, increases the risk of a borderline curative or palliative resection. Conversely, neoadjuvant treatment and MDT discussion reduce the risk of borderline curative or palliative resection.
Mathematical modeling for electromagnetic shielding effectiveness characterization of metalized nonwoven fabrics
Authors: Hu Shi , Wang Dan , Křemenáková Dana , Militký Jiří 
Published: December 2023

Previously established models for electromagnetic shielding effectiveness in metallized textiles have limitations in accurately forecasting the shielding effectiveness of metallized nonwovens. In response, this study embarks on a exploration aimed at formulating a mathematical model capable of predicting the electromagnetic shielding effectiveness specific to metallized nonwoven fabrics. By converting the nonwoven parameters into suitable woven parameters and optimizing the existing models, a refined mathematical model is proposed. To validate the feasibility of the model, experimental verification is conducted using three commercial copper coated nonwoven polyester fabrics CuPET10/20/30. At the 1.5 GHz frequency point, both the values derived from the newly prediction model and the experimental observations exhibited satisfied compatibility across all three samples. However, at the 3 GHz frequency point, a noticeable disparity was observed for CuPET10, with the experimental SE value measuring 47.78 dB, deviating from the SE range projected by the predictive model, which encompassed values between 41.18 dB and 45.76 dB. In contrast, the experimental SE values of CuPET20 and CuPET30 at 3 GHz stood at 57.8 dB and 68.56 dB, respectively, closely aligning with the model's predicted SE range of 53.6 dB–63.7 dB and 60.02 dB–70.65 dB, respectively. The two-sample p-test was performed in the frequency range from 0.5 GHz to 3 GHz. The results reveal a significant level of agreement between the average shielding effectiveness (SE) value predicted by the proposed model and the measured SE value from samples CuPET20 and CuPET30, which p value are 0.16 and 0.06.
The Effects of Laughter Yoga on Perceived Stress, Positive Psychological Capital, and Exercise Capacity in Lung Cancer Chemotherapy Patients: A Pilot Randomized Trial
Authors: Han Shuangrong , Zhang Luyao , Li Qiufang , Wang Xiaokai , Lian Shali 
Published: December 2023

Background: Lung cancer is the malignant tumor with the highest morbidity and mortality rate in China. Although chemotherapy is effective in improving clinical symptoms, it causes a variety of acute and chronic side effects, seriously aggravating the psychological stress of patients. Laughter Yoga as a new type of aerobic exercise can effectively reduce stress levels and increase positive mood in patients. This study aimed to examine the effects of laughter yoga on perceived stress, positive psychological capital, and exercise capacity in lung cancer patients. Methods: This study was a randomized, single-blind, parallel-group trial. The study enrolled 84 lung cancer chemotherapy patients from a general hospital in central China. These patients were randomly allocated to control and intervention groups (n = 42 per group) after baseline assessments. Patients in the control group received routine care and those in the intervention group received laughter yoga intervention. Perceived stress, positive psychological capital, and exercise capacity were assessed at baseline, immediately post-intervention. Results: During the implementation of the study, there were 2 dropouts in each of the intervention and control groups. Ultimately, 80 patients in the control and intervention groups completed the trial. Patients who received laughter yoga intervention had significantly higher scores in positive psychological capital ( P < .01, Cohen’s d = 0.692) and exercise capacity ( P < .01, Cohen’s d = 0.659). Discernible differences were also observed in perceived stress ( P < .01, Cohen’s d = 1.087) between the 2 groups. Conclusions: The results of this study suggest that laughter yoga is an effective way and may produce beneficial effects on perceived stress, positive psychological capital and exercise capacity.
Pregnancy outcomes in female multiple sclerosis patients exposed to intramuscular interferon beta-1a or peginterferon beta-1a reported in a German Patient Support Programme – results from the non-interventional post-authorization safety study PRIMA
Authors: Klehmet Juliane , Begus-Nahrmann Yvonne , Taipale Kirsi , Niemczyk Gabriele , Rehberg-Weber Karin 
Published: December 2023

Background: Based on data from two large cohort studies, a label update became applicable for the class of interferon beta therapies in 9/2019, allowing interferons during pregnancy and breastfeeding. Objective: To assess pregnancy outcomes of women with multiple sclerosis (MS) exposed to peginterferon beta-1a or intramuscular interferon beta-1a therapy (IFN). Design: Non-interventional post-authorization safety study. Methods: PRIMA was conducted from April to October 2021 in Germany. Retrospective pregnancy data were retrieved from adult female patients diagnosed with relapsing-remitting MS or clinically isolated syndrome, exposed to IFN before or during pregnancy and registered in the patient support programme (PSP) of the marketing authorization holder’s MS Service Centre. The primary endpoint was the outcome of pregnancy. Prospective postpartum data were collected from mothers reporting live births. Results: In total, 426 women reporting 542 pregnancies between December 2001 and July 2020 (14 pregnancies after the label update) were enrolled. Among patients with confirmed exposure during pregnancy ( N = 362), 306 pregnancies (84.5%) resulted in live births (77.6% without defects, 1.9% with defects and 4.4% preterm). Spontaneous abortion, elective termination and stillbirth were reported in 10.9%, 2.8% and 0.2% of the cases, respectively. Higher rates of spontaneous abortions were reported in women with continuous IFN use. A total of 162 women completed the questionnaire for 192 live births within the prospective study part. Mothers restarted IFN therapy or switched to another disease-modifying therapy postpartum in 51.0% and 14.1% of cases, respectively. 158/192 infants (82.3%) were breastfed [34/158 (21.5%)] during IFN therapy. Postpartum relapse activity was low (mothers of 87.3% of breastfed infants remained relapse-free during lactation). Conclusion: Overall, the prevalence of spontaneous abortions and congenital anomalies of females exposed to IFN exposure before or during pregnancy was within the range reported for the general population. Most mothers paused IFN during pregnancy and breastfeeding. Relapse activity during pregnancy and lactation was observed to be low. These real-world data from a PSP corroborate European and Scandinavian registry data. Trial registration: NCT04655222, EUPAS38347.
Mental and behavioural disorders increase the risk of tendon rupture after flexor tendon repair in zone I and II
Authors: Svingen Jonas , Arner Marianne 
Published: December 2023

Introduction The effect of mental and behavioural disorders (MBD) on the risk of tendon ruptures after flexor tendon repair is not well understood. This study aimed to analyse the association between MBD and tendon rupture after flexor tendon repair in zones I and II. Methods Data from the Swedish National Registry for Hand Surgery (HAKIR) on patients with a complete flexor tendon repair at our department between 2012 and 2019 were followed for a minimum of 2 years to assess the rate of rupture. Independent variables were collected from HAKIR and clinical records: prevalence MBD based on ICD-10 codes F0-F99, age, sex, injured tendon, number of injured fingers, day to surgery, core suture, digital nerve injury, smoking, injury mechanism, and rehabilitation method. Multiple logistic regression was used to assess the association between variables. Results A cohort of 593 patients with 49 ruptures (8.2%) was identified. Potential causes of rupture were non-adherence behaviour in 16 (33%), accidents in seven (14%), infections in six (12%), and no clear cause in 20 (41%) patients. Patients with MBD had an association to rupture (OR 3.6), 17.7% ruptures compared to 7.2% in patients with no diagnosed disorders. Patients >50 years of age had a higher risk compared to patients <25 years (OR 4.3), 15% compared to 3.9%' respectively. Men had a higher risk compared to women (OR 2.9), 10% compared to 4.3%' respectively. Conclusion We identified an association between the prevalence of mental and behavioural disorders and rupture after flexor tendon repair.
Acceptability of a cross-sectoral hospital pharmacist intervention for patients in transition between hospital and general practice: a mixed methods study
Authors: Sørensen Charlotte Arp , Jeffery Linda , Roelsgaard Klaus , Gram Solveig , Falhof Jannik , Harbig Philipp , Olesen Charlotte 
Published: December 2023

Background and objective: Drug-related problems (DRPs) are often seen when a patient is transitioning from one healthcare sector to another, for example, when a patient moves from the hospital to a General Practice (GP) setting. This transition creates an opportunity for information on medication changes and follow-up plans to be lost. A cross-sectoral hospital pharmacist intervention was developed and pilot-tested in a large GP clinic. The intervention included medication history, medication reconciliation, medication review, follow-up telephone calls, identification of possible DRPs and communication with the GP. It is unknown whether the intervention is transferable to other GP clinics. The aim of the study was to explore similarities and differences between GP clinics in descriptive data and intervention acceptability. Methods: A convergent mixed methods study design was used. The intervention was tested in four GP clinics with differing characteristics. Quantitative data on the GP clinics, patients and pharmacist activities were collected. Qualitative data on the acceptability were collected through focus group interviews with general practitioners, nurses and pharmacists. The Theoretical Framework of Acceptability was used. Results: Overall, the intervention was found acceptable and relevant by all. There were differences between the GP clinics in terms of size, daily physician work form and their use of pharmacists for ad hoc tasks. There were similarities in patient characteristics across GP clinics. Therefore, the intervention was found equally relevant for all of the clinics. Shared employment with unique access to health records in both sectors was important in the identification and resolution of DRPs. Economy was a barrier for further implementation. Conclusions: The intervention was found acceptable and relevant by all; therefore, it was considered transferable to other GP clinics. Hospital pharmacists were perceived to be relevant healthcare professionals to be utilized in GP, in hospitals and in the cross-sectoral transition of patients.
scInterpreter: a knowledge-regularized generative model for interpretably integrating scRNA-seq data
Authors: Guo Zhen-Hao , Wu Yan , Wang Siguo , Zhang Qinhu , Shi Jin-Ming , Wang Yan-Bin , Chen Zhan-Heng 
Published: December 2023

Abstract
Background
The rapid emergence of single-cell RNA-seq (scRNA-seq) data presents remarkable opportunities for broad investigations through integration analyses. However, most integration models are black boxes that lack interpretability or are hard to train.

Results
To address the above issues, we propose scInterpreter, a deep learning-based interpretable model. scInterpreter substantially outperforms other state-of-the-art (SOTA) models in multiple benchmark datasets. In addition, scInterpreter is extensible and can integrate and annotate atlas scRNA-seq data. We evaluated the robustness of scInterpreter in a variety of situations. Through comparison experiments, we found that with a knowledge prior, the training process can be significantly accelerated. Finally, we conducted interpretability analysis for each dimension (pathway) of cell representation in the embedding space.

Conclusions
The results showed that the cell representations obtained by scInterpreter are full of biological significance. Through weight sorting, we found several new genes related to pathways in PBMC dataset. In general, scInterpreter is an effective and interpretable integration tool. It is expected that scInterpreter will bring great convenience to the study of single-cell transcriptomics.
FRIZZLE PANICLE (FZP) regulates rice spikelets development through modulating cytokinin metabolism
Authors: Wang Wei , Chen Wenqiang , Wang Junmin 
Published: December 2023

Abstract
Background
The number of grains per panicle is an important factor in determining rice yield. The DST-OsCKX2 module has been demonstrated to regulate panicle development in rice by controlling cytokinin content. However, to date, how the function of DST-OsCKX2 module is regulated during panicle development remains obscure.

Result
In this study, the ABNORMAL PANICLE 1 (ABP1), a severely allele of FRIZZY PANICLE (FZP), exhibits abnormal spikelets morphology. We show that FZP can repress the expression of DST via directly binding to its promotor. Consistently, the expression level of OsCKX2 increased and the cytokinin content decreased in the fzp mutant, suggesting that the FZP acts upstream of the DST-OsCKX2 to maintain cytokinin homeostasis in the inflorescence meristem.

Conclusions
Our results indicate that FZP plays an important role in regulating spikelet development and grain number through mediating cytokinin metabolism.