bluuebunny/crossref_metadata_2025_split huggingface dataset:
Lewy body pathology modifies risk factors for cerebral amyloid angiopathy when comorbid with Alzheimer's disease pathology
Authors: Pillai Jagan A. , Bena James , Tousi Babak , Rothenberg Kasia , Keene C. Dirk , Leverenz James B. 
Published: February 2024

AbstractINTRODUCTIONCerebral amyloid angiopathy (CAA) often accompanies dementia‐associated pathologies and is important in the context of anti‐amyloid monoclonal therapies and risk of hemorrhage.METHODSWe conducted a retrospective neuropathology‐confirmed study of 2384 participants in the National Alzheimer Coordinating Center cohort (Alzheimer's disease [AD], n = 1175; Lewy body pathology [LBP], n = 316; and mixed AD and LBP [AD‐LBP], n = 893). We used logistic regression to evaluate age, sex, education, APOE ε4, neuritic plaques, and neurofibrillary tangles (NFTs) in CAA risk.RESULTSAPOE ε4 increased CAA risk in all three groups, while younger age and higher NFT stages increased risk in AD and AD‐LBP. In AD‐LBP, male sex and lower education were additional risk factors. The odds of APOE ε4 carrier homozygosity related to CAA was higher in LBP (25.69) and AD‐LBP (9.50) than AD (3.17).DISCUSSIONAD and LBPs modify risk factors for CAA and should be considered in reviewing the risk of CAA.Highlights
Lewy body pathology modifies risk factors for cerebral amyloid angiopathy (CAA) when present along with Alzheimer's disease (AD) neuropathology.
In the context of anti‐amyloid monoclonal therapies and their associated risks for hemorrhage, the risk of underlying CAA in mixed dementia with Lewy body pathology needs to be considered.
Energy‐Efficient Electrosynthesis of High Value‐Added Active Chlorine Coupled with H2 Generation from Direct Seawater Electrolysis through Decoupling Electrolytes
Authors: Zhu Wenxin , Wei Ziyi , Ma Yiyue , Ren Meirong , Fu Xue , Li Min , Zhang Chunling , Wang Jianlong , Guo Shaojun 
Published: February 2024

AbstractDirect saline (seawater) electrolysis is a well‐recognized system to generate active chlorine species for the chloride‐mediated electrosynthesis, environmental remediation and sterilization over the past few decades. However, the large energy consumption originated from the high cell voltage of traditional direct saline electrolysis system, greatly restricts its practical application. Here, we report an acid‐saline hybrid electrolysis system for energy‐saving co‐electrosynthesis of active chlorine and H2. We demonstrate that this system just requires a low cell voltage of 1.59 V to attain 10 mA cm−2 with a large energy consumption decrease of 27.7 % compared to direct saline electrolysis system (2.20 V). We further demonstrate that such acid‐saline hybrid electrolysis system could be extended to realize energy‐saving and sustainable seawater electrolysis. The acidified seawater in this system can absolutely avoid the formation of Ca/Mg‐based sediments that always form in the seawater electrolysis system. We also prove that this system in the half‐flow mode can realize real‐time preparation of active chlorine used for sterilization and pea sprout production.
Synthesis of N‐Difluoromethyl Carbonyl Compounds from N‐Difluoromethylcarbamoyl Fluorides
Authors: Hu Chunyang , Jiang Lvqi , Guo Zihao , Mumtaz Yasir , Liu Jie , Qin Jiarong , Chen Yixing , Lin Zhongquan , Yi Wenbin 
Published: February 2024

AbstractFluorinated small molecules are commonly used in functional small‐molecule chemistry, and N‐difluoromethyl (N‐CF2H) compounds are particularly intriguing due to their unique and unexplored physiochemical properties. However, despite limited progress, a general methodological approach to the synthesis of N‐CF2H compounds remains elusive. Here, guided by computation, we present a simple and practical protocol to access N‐CF2H amides and related carbonyl derivatives. The protocol involves a one‐pot conversion of thioformamides through desulfurization‐fluorination and acylation, providing N‐difluoromethylcarbamoyl fluoride building blocks that can be further diversified to a variety of unexplored N‐CF2H carbonyl compounds with rich functionality. Additionally, preliminary studies on their properties and stability showcased their potential application in pharmaceuticals and agrochemicals.
Giant Negative Thermal Expansion in Ultralight NaB(CN)4
Authors: Gao Qilong , Jiao Yixin , Sun Qiang , Sprenger Jan A. P. , Finze Maik , Sanson Andrea , Liang Erjun , Xing Xianran , Chen Jun 
Published: February 2024

AbstractNegative thermal expansion (NTE) is crucial for controlling the thermomechanical properties of functional materials, albeit being relatively rare. This study reports a giant NTE (αV∼−9.2 ⋅ 10−5 K−1, 100–200 K; αV∼−3.7 ⋅ 10−5 K−1, 200–650 K) observed in NaB(CN)4, showcasing interesting ultralight properties. A comprehensive investigation involving synchrotron X‐ray diffraction, Raman spectroscopy, and first‐principles calculations has been conducted to explore the thermal expansion mechanism. The findings indicate that the low‐frequency phonon modes play a primary role in NTE, and non‐rigid vibration modes with most negative Grüneisen parameters are the key contributing factor to the giant NTE observed in NaB(CN)4. This work presents a new material with giant NTE and ultralight mass density, providing insights for the understanding and design of novel NTE materials.
Impact of grey energy on optimal wall insulation thickness
Authors: Delmonte Branca , Latz Sebastian , Youmbi Jules , Maas Stefan 
Published: February 2024

AbstractFor decades efforts have been made to reduce the greenhouse gases emissions of buildings by reducing their energy demand with governmental regulations in Europe, pushing towards very low thermal transmittances (U‐values) with ever thicker insulation layers for new buildings. However, there is no linear relationship between the insulation thickness and the heat losses. Therefore, above a certain thickness the consumption of buildings does not decrease significantly. Hereafter a life cycle analysis, including emissions before the building becomes operational is applied to evaluate the impact of the increasing thickness of components on the overall emissions. Publicly available product data sheets are used to compare four insulation materials under three scenarios. These analyses yield interesting results showing that energy‐intensive insulation materials lead to a negative impact in the overall energy balance after a certain thickness. Even though there is not always a pronounced optimum insulation thickness, it is logical that further reductions in U‐value for new buildings should hence be carefully evaluated. The results show that the optimal thickness is around 20 cm for most materials, while the important major savings come from the first 10 cm.
Enabling the use of lithium bis(trifluoromethanesulfonyl)imide as electrolyte salt for Li‐ion batteries based on silicon anodes and Li(Ni0.4Co0.4Mn0.2)O2 cathodes by salt additives
Authors: Asheim K. , Holsen I. F. , Renmann V. , Blanco M. V. , Vullum P. E. , Wagner N. P. , Mæhlen J.P. , Svensson A. M. 
Published: February 2024

AbstractLithium bis(trifluoromethanesulfonyl)imide (LiFSI) is a promising alternative salt for Li‐ion batteries. Unlike the conventional LiPF6, it is not prone to HF formation, and thus resistant to moisture. However, for cell voltages relevant for high energy cathodes (>4.2 V), the aluminium current collector will corrode in electrolytes based on this salt, and mitigation strategies are needed. Here, the use of Lithium tetrafluoroborate (LiBF4) and Lithium difluoro(oxalato)borate (LiDFOB) salts as additives is investigated, in order to enable the use of LiFSI‐based electrolytes. The performance of the electrolytes is evaluated separately for high content silicon anodes,
(NMC442) cathodes and the aluminium current collector by electrochemical methods and post mortem analysis by SEM imaging and X‐ray photoelectron spectroscopy (XPS). Electrolytes with LiDFOB as additive showed the best performance for all components, and were therefore selected for cycling in full cells, composed of silicon anodes and NMC442. Results show that LiFSI‐based electrolytes with LiDFOB additive has an electrochemical performance similar to conventional electrolytes, and is thus a competitive, alternative electrolyte with a low fluorine content. Furthermore, it is verified that the good SEI forming properties of LiFSI based electrolytes known from cycling in half cells, is also preserved during cycling in full cells
Selective hydrophobic interaction chromatography for high purity of supercoiled DNA plasmids
Authors: Božič Klemen , Sedlar Ajda , Kralj Špela , Černigoj Urh , Štrancar Aleš , Sekirnik Rok 
Published: February 2024

AbstractHigh purity of plasmid DNA (pDNA), particularly in supercoiled isoform (SC), is used for various biopharmaceutical applications, such as a transfecting agent for production of gene therapy viral vectors, for pDNA vaccines, or as a precursor for linearized form that serves as a template for mRNA synthesis. In clinical manufacturing, pDNA is commonly extracted from Escherichia coli cells with alkaline lysis followed by anion exchange chromatography or tangential flow filtration as a capture step for pDNA. Both methods remove a high degree of host cell contaminants but are unable to generically discriminate between SC and open‐circular (OC) pDNA isoforms, as well as other DNA impurities, such as genomic DNA (gDNA). Hydrophobic interaction chromatography (HIC) is commonly used as polishing purification for pDNA. We developed HIC‐based polishing purification methodology that is highly selective for enrichment of SC pDNA. It is generic with respect to plasmid size, scalable, and GMP compatible. The technique uses ammonium sulfate, a kosmotropic salt, at a concentration selective for SC pDNA binding to a butyl monolith column, while OC pDNA and gDNA are removed in flow‐through. The approach is validated on multiple adeno‐associated virus‐ and mRNA‐encoding plasmids ranging from 3 to 12 kbp. We show good scalability to at least 300 mg of >95% SC pDNA, thus paving the way to increase the quality of genomic medicines that utilize pDNA as a key raw material.
Climate‐neutral labeling for climate‐friendly vs. climate‐harmful food products: Consumer perceptions and implications
Authors: Stremmel Gesa , Elshiewy Ossama , Boztug Yasemin 
Published: February 2024

AbstractGiven the increasing prevalence of climate‐neutral labeled products in the actual marketplace, this study analyzes the impact of climate‐neutral labeling on consumer perceptions and purchase propensity. Only for climate‐harmful products we found that climate‐neutral labeling alters product perceptions and purchase propensity (while not for climate‐friendly products). For climate‐harmful products, a climate‐neutral label leads consumers to value the objective contribution to climate protection associated with the label but also evokes various biased inferences (i.e., the product is perceived to [1] be less resource intensive, [2] use fewer chemicals and pesticides during agricultural production, and [3] be superior regarding ethical product benefits like fair trade and animal welfare). We also found that a more transparent labeling practice, which provides additional information of the label scope, reduces the biased inferences (1–2) or even avoids them (3).
Combretum micranthum G. Don (Combretaceae): A Review on Traditional Uses, Phytochemistry, Pharmacology and Toxicology
Authors: Tine Yoro , Sene Madieye , Gaye Cheikhouna , Diallo Alioune , Ndiaye Benjamin , Ndoye Idrissa , Wele Alassane 
Published: February 2024

AbstractCombretum micranthum (Combretaceae) is a medicinal plant widely known and used in Africa to treat a variety of conditions such as diabetes, fever, coughs, bronchitis, diarrhea, pain, malaria and liver disorders, among others. Due to its wide traditional use, in this review, published scientific reports on its composition and pharmacological properties were explored by conducting a literature search of databases. To date, 155 organic compounds including 34 flavonoids, 16 phenolic acids, 14 alkaloids, 15 fatty acids, 14 terpenoids/steroids, 24 amino acids, 8 carbohydrate substances and 30 other organic compounds have been identified from this plant. In addition to these organic compounds, 6 minerals (potassium nitrate, calcium, magnesium, potassium, sodium, iron and zinc) have also been reported. In vitro and in vivo studies have shown that these phytochemicals and plant extracts have a wide range of pharmacological potential, including antibacterial, antiviral, antioxidant, antidiabetic, anti‐inflammatory, analgesic, antihypertensive, nephroprotective, hepatoprotective, anxiolytic, anti‐cholinesterase and antidiarrheal activities. Additionally, no harmful effects have been revealed through studies. Thus, this study could constitute a valuable reference for the valorization of C. micranthum in the pharmaceutical industry.
Methylation of Phenyl Rings in Ester‐Stabilized Phosphorus Ylides Vastly Enhances Their Protonophoric Activity
Authors: Rokitskaya Tatyana I. , Kirsanov Roman S. , Khailova Ljudmila S. , Panteleeva Alisa A. , Lyamzaev Konstantin G. , Korshunova Galina A. , Kotova Elena A. , Antonenko Yuri N. 
Published: February 2024

AbstractWe have recently discovered that ester‐stabilized phosphorus ylides, resulting from deprotonation of a phosphonium salt such as [Ph3PCH2COOR], can transfer protons across artificial and biological membranes. To create more effective cationic protonophores, we synthesized similar phosphonium salts with one ((heptyloxycarbonylmethyl)(p‐tolyl)bromide) or two ((butyloxycarbonylmethyl)(3,5‐xylyl)osphonium bromide) methyl substituents in the phenyl groups. The methylation enormously augmented both protonophoric activity of the ylides on planar bilayer lipid membrane (BLM) and uncoupling of mammalian mitochondria, which correlated with strongly accelerated flip‐flop of their cationic precursors across the BLM.
A functional bread produced by supplementing wheat flour with high β‐glucan hull‐less barley flour
Authors: Koksel Hamit , Cetiner Buket , Ozkan Kubra , Tekin‐Cakmak Zeynep Hazal , Sagdic Osman , Sestili Francesco , Jilal Abderrazek 
Published: February 2024

AbstractBackground and ObjectivesHigh β‐glucan hull‐less barley (cv. Chifaa) was used in functional bread production. Its technological and nutritional properties were compared with the one produced from bread wheat flour.FindingsIncreasing levels of whole barley flour supplementation resulted in consistent increases in the Farinograph water absorption due to the high hydration capacity of β‐glucan in barley flour. Increasing whole barley flour supplementation levels had significant deteriorative effects on all of the bread quality characteristics probably due to dilution of gluten proteins. On the contrary, the mineral, β‐glucan, and phenolic contents and antioxidant capacities of breads supplemented with Chifaa were significantly higher than those of the bread produced from bread wheat.ConclusionThe glycemic index (GI) of the bread supplemented with 60% barley flour (66.4) was medium while the GI of the 45% barley flour‐supplemented bread (70.1) was very close to the limit value of the medium GI. The lower GI of the barley flour‐supplemented breads might be attributed to their higher β‐glucan contents. The results indicated that 3 g of β‐glucan can be provided from barley flour‐supplemented bread (at 45% and 60%), which is the limit to bear health claim.Significance and NoveltyThe results of the present study indicated that high β‐glucan hull‐less barley can be used to produce functional breads with better nutritional properties. The findings of this study may provide insights that can contribute to the studies on functional foods.
Supervision of counselor trainees in integrated behavioral health settings
Authors: Giresunlu Yesim , Kemer Gulsah , Akpinar‐Elci Muge 
Published: February 2024

AbstractWe pursued an understanding of 21 site supervisors’ perspectives on the focus of counseling supervision in integrated behavioral health settings. Presenting organizational and clinical viewpoints, site supervisors reported mentoring supervisees on administrative and interdisciplinary work along with process‐oriented supervision practices.
A Guide for Mono‐Selective N‐Methylation, N‐Ethylation, and N‐n‐Propylation of Primary Amines, Amides, and Sulfonamides and Their Applicability in Late‐Stage Modification
Authors: Templ Johanna , Schnürch Michael 
Published: February 2024

AbstractThis review provides a comprehensive overview of mono‐alkylation methodologies targeting crucial nitrogen moieties – amines, amides, and sulfonamides – found in organic building blocks and pharmaceuticals. Emphasizing the intersection of chemical precision with drug discovery, the central challenge addressed is achieving one‐pot mono‐selective short‐chain N‐alkylations (methylations, ethylations, and n‐propylations), preventing undesired overalkylation. Additionally, sustainable, safe, and benign alternatives to traditional alkylating agents, including alcohols, carbon dioxide, carboxylic acids, nitriles, alkyl phosphates, quaternary ammonium salts, and alkyl carbonates, are explored. This review, categorized by the nature of the alkylating agent, aids researchers in selecting suitable methods for mono‐selective N‐alkylation.
A global perspective on stepping down chronic spontaneous urticaria treatment: Results of the Urticaria Centers of Reference and Excellence SDown‐CSU study
Authors: Türk Murat , Kocatürk Emek , Ertaş Ragıp , Ensina Luis Felipe , Mariel Ferrucci Silvia , Grattan Clive , Vestergaard Christian , Zuberbier Torsten , Maurer Marcus , Giménez‐Arnau Ana Maria 
Published: February 2024

AbstractBackgroundAlthough there have been significant advances in the treatment of chronic spontaneous urticaria (CSU) in recent years, there remains a lack of clear guidance on when and how to step down treatment in responders. This study aims to investigate stepping down approaches of different steps of CSU treatment from a global perspective.Methods“Stepping down chronic spontaneous urticaria treatment” (SDown‐CSU) is an international, multicenter, observational, cross‐sectional, survey‐based study of the Urticaria Centers of Reference and Excellence (UCARE) network. The questionnaire included 48 questions completed by physicians in the UCARE network.ResultsSurveys completed by 103 physicians from 81 UCAREs and 34 countries were analyzed. Seventy‐eight percent of the participants responded that they had a national urticaria management guideline written by their professional societies and 28% responded that they had to operate under a regulatory guideline proposed by central health funding organizations. Seventy‐two and 58.7% of these national recommendations do not contain any detailed information on when and/or how CSU treatment should be discontinued. There was a lack of detailed information on antihistamines and cyclosporine in particular. A predefined maximum duration was generally not applicable to omalizumab and cyclosporine (81% and 82%, respectively). Nearly all UCAREs step down omalizumab within 6 months from the first controlled status and 42% discontinue cyclosporine after 6 months regardless of the control status.ConclusionsThe findings from the SDown‐CSU study clearly highlight a global need for guidance on the process of stepping down treatment in CSU. Additionally, the study offers a step‐down algorithm applicable to all stages of CSU treatment.
Meta‐analysis of microarray data to determine gene indicators involved in cisplatin resistance in non‐small cell lung cancer
Authors: Sheikhshabani Somayeh Hashemi , Modarres Paratoo , Ghafouri‐Fard Soudeh , Amini‐Farsani Zeinab , Khodaee Lavin , Shaygan Nasibeh , Amini‐Farsani Zahra , Omrani Mir Davood 
Published: February 2024

AbstractBackgroundLung cancer is a major cause of cancer‐related mortality worldwide, with a 5‐year survival rate of approximately 22%. Cisplatin is one of the standard first‐line chemotherapeutic agents for non‐small cell lung cancer (NSCLC), but its efficacy is often limited by the development of resistance. Despite extensive research on the molecular mechanisms of chemoresistance, the underlying causes remain elusive and complex.AimsWe analyzed three microarray datasets to find the gene signature and key pathways related to cisplatin resistance in NSCLC.Methods and ResultsWe compared the gene expression of sensitive and resistant NSCLC cell lines treated with cisplatin. We found 274 DEGs, including 111 upregulated and 163 downregulated genes, in the resistant group. Gene set enrichment analysis showed the potential roles of several DEGs, such as TUBB2B, MAPK7, TUBAL3, MAP2K5, SMUG1, NTHL1, PARP3, NTRK1, G6PD, PDK1, HEY1, YTHDF2, CD274, and MAGEA1, in cisplatin resistance. Functional analysis revealed the involvement of pathways, such as gap junction, base excision repair, central carbon metabolism, and Notch signaling in the resistant cell lines.ConclusionWe identified several molecular factors that contribute to cisplatin resistance in NSCLC cell lines, involving genes and pathways that regulate gap junction communication, DNA damage repair, ROS balance, EMT induction, and stemness maintenance. These genes and pathways could be targets for future studies to overcome cisplatin resistance in NSCLC.
Correlates of supportive care needs among Asian Americans with colorectal, liver, or lung cancer from a web‐based patient navigation portal intervention: The Patient COUNTS study
Authors: Wang Katarina , Chu Janet N. , Oh Debora L. , Shariff‐Marco Salma , Allen Laura , Kuo Mei‐Chin , Wong Ching , Bui Hoan , Chen Junlin , Li Feng Ming , Ma Carmen , Truong Angeline , Gomez Scarlett L. , Nguyen Tung T. , Tsoh Janice Y. 
Published: February 2024

AbstractBackgroundCancer is the leading cause of death among Asian Americans, who often face barriers to cancer care. Cancer supportive care needs among Asian Americans remain understudied.AimsWe examined cancer supportive care needs and participant factors correlated with these needs, identified profiles of supportive care needs, and examined whether needs profiles are associated with quality of life among Asian American adults.Methods and ResultsWe recruited 47 Asian American adults with colorectal, liver, or lung cancer who spoke Chinese, English, or Vietnamese, and were starting or undergoing cancer treatment. We assessed cancer supportive care needs in four domains: cancer information, daily living, behavioral health, and language assistance. Hierarchical cluster analysis was used to identify clusters of participants based on their supportive need profiles to further examine the association between need profiles and quality of life (QoL) assessed by the Functional Assessment of Cancer Therapy.Participants (mean age = 57.6) included 72% males and 62% spoke English less than very well. Older participants (age ≥ 65) and those with annual income <$50K reported higher daily living needs. Men and younger participants (age < 50) reported higher behavioral health needs. We found three clusters displaying distinct cancer supportive need profiles: Cluster 1 (28% of the sample) displayed high needs across all domains; Cluster 2 (51%) had low needs across all domains; and Cluster 3 (21%) had high needs for cancer information and daily living. Cluster 1 participants reported the lowest QoL.ConclusionCancer supportive care needs among Asian American patients with colorectal, liver, and lung cancer were associated with patient characteristics and QoL. Understanding cancer supportive care needs will inform future interventions to improve care and QoL for Asian American patients with cancer. ClinicalTrials.gov Identifier: NCT03867916.