bluuebunny/crossref_metadata_2025_split huggingface dataset:
Metallacages with 2,6-dipicolinoylbis(N,N-dialkylthioureas) as novel platforms in nuclear medicine for 68Ga, 177Lu and 198Au
Authors: Baitullina Anna , Claude Guilhem , Sucena Suelen F. , Nisli Eda , Scholz Cedric , Bhardwaj Punita , Amthauer Holger , Brenner Winfried , Geppert Christopher , Gorges Christian , Abram Ulrich , da Silva Maia Pedro Ivo , Spreckelmeyer Sarah 
Published: November 2023

Abstract
Background
Heterometallic gold metallacages are of great interest for the incorporation of several cations. Especially in nuclear medicine, those metallacages can serve as a platform for radionuclides relevant for imaging or therapy (e.g. 68Ga or 177Lu). Moreover, the radionuclide 198Au is an attractive beta emitter, for potential application in nuclear medicine. Here, we aim to synthesize a new set of gold metallacages and to study their ability to coordinate to 68Ga, 177Lu and 198Au.

Results
New heterometallic gold metallacages of composition [M{Au(Lmorph-κS)}3] (M = La3+, Tb3+, Lu3+ or Y3+) and [Ga{Au(Lmorph-κS)}2]NO3 have been synthesized from 2,6-dipicolinoylbis(N,N-morpholinylthiourea) (H2Lmorph) with [AuCl(THT)] and the target M3+ metal ions in yields ranging from 33 (Lu) to 62% (Tb). The characterization of the compounds bases on ESI–MS, 1H NMR, IR, EA and single-crystal X-ray diffraction techniques (all except the Ga derivative). Selected gold cages derived from H2Lmorph were compared to previously reported gold cages that were derived from 2,6-dipicolinoylbis(N,N-diethylthiourea) (H2Ldiethyl). The tested metallacages show similar IC50 values close to that of auranofin in four different cancer cell lines (MCF-7, PC-3, U383, U343), e.g. 4.5 ± 0.7 µM for [Ga{Au(Ldiethyl)}2]NO3 on PC-3. The radiolabeling experiments thereof show high radiochemical purities with 68Ga and 198Au and low radiochemical purity with 177Lu.

Conclusions
The results indicate that these gold metallacages could serve as a novel platform for inclusion of different (radio)nuclides with potential theranostic applications in nuclear medicine.
Development and content validation of a sunlight exposure diary in patients with erythropoietic protoporphyria
Authors: Mathias Susan D. , Burke Laurie , Colwell Hilary H. , Mensing George , Savage Will , Naik Hetanshi 
Published: November 2023

AbstractBackgroundErythropoietic protoporphyria is a rare, inherited disorder presenting in early childhood with severe, painful phototoxicity. EPP has significant impacts on health-related quality of life, though there is variable disease severity. Accurately capturing how much time individuals with EPP can spend outdoors before they develop symptoms is critical to understanding HRQoL and measuring therapeutic response. Therefore, the goal of this study was to develop a comprehensive and content valid sun exposure diary to assess the efficacy of new therapies in individuals with EPP.MethodsQualitative interviews were conducted with adult and adolescent EPP participants, as well as five clinical experts, to obtain their input on the content of an existing sun exposure diary. Revisions to the diary were made based on evidence generated in cognitive debriefing interviews analyzed in eight consecutive groups of EPP participant.ResultsInterviews were conducted with 17 adults and 6 adolescents with EPP. The average age of adults was 40 years and of adolescents was 14 years. Clinical experts thought the original diary needed clarification on the description of symptoms, how time outdoors was captured, and the distinction between direct vs. indirect sunlight. Participants with EPP also noted these items needed revision, and that the distinction between prodromal symptoms and full reaction symptoms should be clarified. In the final diary version, participants with EPP found most items to be clear and easy to complete/think about. Seventy-six percent of participants (13/17) asked thought the diary was easy to complete. The remainder thought the majority of the diary was easy to complete with the exception of select questions.ConclusionsEvaluating a new treatment for EPP requires accurately capturing time in sunlight and symptoms in this unique disorder. The newly developed sun exposure diary is content valid and can be used to assess important aspects of symptoms and daily life and therefore evaluate clinically meaningful therapeutic response.
Qualitative differences in perspective on children’s quality of life between children with cerebral palsy and their parents
Authors: Swift Elena , Gibbs Lisa , Reddihough Dinah , Mackinnon Andrew , Davis Elise 
Published: November 2023

Abstract
Background
Cerebral palsy (CP) is one of the most common childhood disabilities, impacting many areas of a child’s life. Increasingly, quality of life (QOL) measures are used to capture holistic wellbeing of children with CP. However most validated QOL measures for children are based on adult perspective only, with limited focus on child perspective. Conceptual differences between children’s and adults’ definitions of QOL may reflect different underlying QOL models which contribute to measurement score divergence. This qualitative study investigated the conceptual meaning of QOL for children with CP, comparing child and parent perspectives. Eighteen families completed 8 child interviews and 18 parent interviews. Children (11 boys, 7 girls) represented the spectrum of motor functioning, with comorbidities including epilepsy, intellectual disability, and communication impairments. Child and parent interviews were analysed separately using constructivist grounded theory methods and then findings were integrated to examine similarities and differences.

Results
All participants sought child inclusion in social activities, education, and recreation, requiring negotiation, adaptations, and advocacy. Five conceptual categories emerged from child interviews: socialising, play, negotiating limitations, self-identity, and developing agency. This reflected an individual model of QOL supporting child development goals. Parent interview findings revealed concepts related to child-specific QOL (day-to-day functioning and enabling child goals), as well as parent and family functioning concepts aligned to models of “family QOL”, embracing impacts of family relationships and the interdependence of QOL among family members.

Conclusions
This study identified similarities and differences in child and parent perceptions of QOL for the child with CP. Children provided insights into the importance of play and peer support, and their developing self-identity and sense of agency. Self-directed free play, especially, was identified by children but not parents as a central everyday activity promoting wellbeing and social inclusion. Parents discussed family functioning and aspects outside of child sight, such as managing time and financial resources. Relying on parents’ perspective alone to model child QOL misses valuable information that children contribute. Equally, child report alone misses parent experiences that directly influence child QOL. There is value in incorporating family QOL into parent reports while developing a conceptually separate child self-report QOL instrument.
Evaluation of the autonomic nervous system in patients with essential tremor
Authors: Nassar Mahmoud H. , Tageldin Elsayed A. , Ragab Osama A. 
Published: November 2023

Abstract
Background
Essential tremor (ET) is a prevalent movement disorder that may be linked to neurodegenerative changes. It is marked by a mix of motor and non-motor symptoms, which include disturbances in the autonomic nervous system. Aim of the study: We aimed to assess autonomic dysfunction in individuals with essential tremor. Thirty patients with essential tremor (Group 1) and 30 age and sex-matched healthy subjects as the control group (Group 2) were recruited. Comprehensive medical and neurological examinations were conducted on all participants, followed by electrophysiological assessments of autonomic function, including heart rate variability (HRV) tests (E/I ratio, Valsalva ratio, 30:15 ratio), adrenergic tests (blood pressure responses to active standing and sustained hand grip), and sympathetic skin response (SSR) tests. Finally, the results of these tests were classified according to the Ewing classification of autonomic failure. Results: The study revealed significant differences between ET patients and the control group. Heart rate variability tests showed a marked difference between the groups. Adrenergic tests, measuring sympathetic innervation, also displayed a significant difference. The sudomotor function test exhibited noteworthy differences in onset latencies and amplitudes in the palm and sole, with ET patients showing prolonged onset latencies and decreased amplitudes. Moreover, the study found a significant correlation between disease severity and autonomic function test results and the Ewing score. Conclusion: The study highlights the presence of autonomic dysfunction in essential tremor patients, with disease severity being associated with the level of autonomic affection, as evidenced by various autonomic function tests and the Ewing score.
Multifocal thoracic intradural extramedullary anaplastic ependymoma: case report and review of the literature
Authors: De Bonis Costanzo , Gazzeri Roberto , Gorgoglione Leonardo 
Published: November 2023

Abstract
Background
Ependymomas are neuroectodermal tumors that grow from the ependymal cells of the ventricles or the central canal of the spinal cord. When the ependymoma is anaplastic, extramedullary, intradural and multifocal, it is a very rare anatomical entity, same as case described by us.

Case presentation
A 44-year-old man had been admitted to our hospital for progressive paralysis of both legs over the past 5 weeks. Contrast-enhanced MRI showed intradural extramedullary tumor at T11 with cord compression and an other more little tumor at T6 level, also intradural and extramedullary. The largest lesion was completely removed by laminectomy. Histology documented an anaplastic ependymoma. Contrast-enhanced brain and spinal MRI showed the results of the previous surgery.

Conclusion
Multifocal intradural extramedullary anaplastic ependymomas are very rare entity. Surgery is the main treatment that can improve prognosis, while radiotherapy is useful, after surgery, in the treatment of residues, recurrences, anaplastic transformations, metastases and multifocal lesions.
Bethesda Category III thyroid nodules: descriptive cytological aspects of a series
Authors: Rocha Júlia Thalita Queiroz , Kanda Rafael Guimarães , Marques Mariangela Esther Alencar , Tagliarini José Vicente , da Silva Mazeto Glaucia Maria Ferreira , Oliveira Cristiano Claudino 
Published: November 2023

Abstract
Background
The Bethesda System for Reporting Thyroid Cytopathology (TBSRTC) is used for cytopathological diagnosis of fine needle aspiration (FNA) of thyroid nodules (TN). Diagnosis of Bethesda Category III (CIII) has estimated malignancy rates of around 10%-30%, which vary between different institutions. Objective. To review cases of FNA interpreted as CIII thyroid nodules. To evaluate cytopathological criteria used to interpret FNA for CIII thyroid nodules and the associations between cytological and radiological aspects. To determine the malignancy rate of thyroid nodules classified as CIII, based on the correlation with surgical procedure. Methods. Retrospective study of FNA’s cytologic criteria of TN classified as CIII, carried out between 2010 and 2016. The patients included in the study were those who underwent the first FNA in the service and who were diagnosed with CIII. The patients had their cytological slides and medical records reviewed to detect the conduct flow followed after the CIII diagnosis. All cases that had histological slides available of their thyroidectomy products, total or partial, reviewed. The associations between clinical, histological and cytological findings were statistically studied. Results. Among 63 patients with resected nodules, 17 (27%) were malignant, 13 of which were papillary thyroid carcinomas. Among the benign cases, 18 patients (28.1%) had chronic lymphocytic thyroiditis/Hashimoto’s thyroiditis. Papillae (p = .004) was the criterion best associated with the diagnosis of malignancy. Conclusion. The malignancy rate was consistent with the rate of malignancy predicted in the TBSRTC. It is important to point out that the sample of this study is relatively small, which compromises specific evaluations and reduces the robustness of the observed data. CIII is extensively studied in the literature, however there is still a need for more precise studies regarding the correlations between cytological findings and other parameters. Probably, more than other categories, CIII may require a combination of cytological, radiological and clinical interpretation, with pathology leading role in this diagnosis process.
Water woes: the institutional challenges in achieving SDG 6
Authors: Evaristo Jaivime , Jameel Yusuf , Tortajada Cecilia , Wang Raymond Yu , Horne James , Neukrug Howard , David Carlos Primo , Fasnacht Angela Maria , Ziegler Alan D. , Biswas Asit 
Published: November 2023

Abstract
Background
Sustainable Development Goal (SDG) 6 envisions a future where everyone has access to clean water and sanitation. Yet, as 2030 looms closer, the complexity of achieving this target becomes apparent, with issues far surpassing basic water infrastructure and utility challenges. The underlying problems lie in broader spheres such as governance, policymaking, and financing.

Main body
The global landscape of water management is marked by complexities that transcend the operational troubles of water utilities. Financial sustainability is a monumental task. And while it is true that water utilities struggle with revenue generation, the broader picture reveals systemic challenges. The true cost of water provision often extends to ecosystem services such as watershed protection. Often, these services are not internalized in the revenue models of utilities but are typically subsidized by governments or simply not considered. Balancing affordability for users with cost recovery for service providers, however, is not just an arithmetic exercise. It is also a question of equitable policies. Non-revenue water (NRW), resulting from physical losses such as leaks, theft, and inaccurate [or lack of] metering, exacerbates existing financial strain. Annual NRW losses are estimated at an astonishing 126 billion cubic meters, costing roughly USD 39 billion. But at the most fundamental level of achieving SDG 6 is misgovernance. Effective water governance demands consistent policies, coherent collaboration among diverse stakeholders, and comprehensive strategies that cater to specific regional contexts. Current models often suffer from fragmented policies, inadequate public-private partnerships, and weak engagement mechanisms. A glaring gap exists between academic advancements in water management and their practical implementation in policymaking. Moreover, international cooperation, while vital, reveals an unequal landscape in knowledge exchange. Knowledge transfer is often skewed, favoring dominant nations while sidelining voices from the Global South. This emphasizes the need for an inclusive, equitable, and context-specific global cooperation model.

Conclusion
The road to realizing SDG 6 is multifaceted, and while on-the-ground solutions are essential, the real success lies in addressing the foundational challenges. This requires innovative financial solutions, reimagining water governance structures, and ensuring all voices, especially from the Global South, are heard and integrated into global policies. As 2030 nears, it is the synergy of governance, finance, and technology that will ultimately make clean water and sanitation a reality for all.
Abiraterone, a rare cause of severe perioperative hypokalemia with unusual presentation as aphonia and quadriparesis: a case report
Authors: Thakore Sakshi , Kaasat Ankita , Thakore Nirdesh , Chundawat Yatendra Singh 
Published: November 2023

Abstract
Background
Oral Abiraterone acetate is a novel antineoplastic agent approved by the FDA for the treatment of metastatic prostate cancer. Abiraterone is an irreversible inhibitor of the 17α-hydroxylase (CYP17) enzyme complex resulting in a reduction of androgens and corticosteroids. It may cause mineralocorticoid excess syndrome; hence, it is prescribed with steroids. Here we describe a case of postoperative severe hypokalemia with unusual presentation in a patient after spine surgery in which abiraterone with prednisolone was continued preoperatively. Anesthetic concerns about the perioperative administration of abiraterone have not been reported in the literature.

Case presentation
An 80-year-old male with a known case of metastatic prostate cancer was posted for spine surgery under general anesthesia. Surgery was uneventful and the patient was extubated after ensuring adequate muscle power and respiratory parameters. Postoperatively, the patient developed aphonia, quadriparesis, and respiratory distress leading to reintubation. After evaluation, severe grade 4 hypokalemia was found to be the causative factor. The patient recovered well after potassium and steroid supplementation. Low potassium and cortisol levels indicate a diagnosis of abiraterone-induced hypokalemia.

Conclusion
Patients on abiraterone require more stringent and vigilant monitoring of potassium and cortisol levels. In such circumstances, it might be advantageous to add additional steroids or substitute alternative steroids.
Synergism study of Bacopa monnieri and Piriformospora indica and its impact on Biomass and metabolite
Authors: Kharde Ashok V. , Kore Supriya V. , Singh Raghvendra P. , Khetmalas Madhukar B. 
Published: November 2023

Abstract
Background
A symbiotic connection between Piriformospora indica and Bacopa monnieri (L.) Wettest, obtained through co-cultivation synergism, was found to improve growth, biomass production, and bacoside content in the plants. Brahmi (B. monnieri L.), a well-known Indian plant prized for its memory-boosting properties, has a lengthy history and a premium price tag. Because of its remarkable ability to colonize a wide variety of plant species, the axenically cultivable mycorrhiza-like endophytic fungus P. indica has gained a lot of interest recently.

Methods
In the current study, fungal spores from recently revived cultures were added to jam bottles next to rooted Brahmi plants for in vitro co-cultivation. The control plants were left without fungal discs. Pre-rooted micro-propagated Brahmi plants were treated with agar discs containing actively growing hyphae. For a period of 3 months, both trials were conducted with a fully randomized setup. Microscopy of the treated and control plant roots verified co-cultivation.

Results
Microscopic examination of the roots of co-cultivated plants reveals a high degree of colonization with host plants. These endophytic fungal structures include intracellular chlamydospores, and arbuscules, an intercellular and intracellular hyphae network, and a mycelial network on the root surface. In both in vitro and in vivo co-cultivation studies, the plant extended the host plant’s lifespan in 3 months by displaying continuous regeneration; in contrast, the control plant displayed signs of senescence. With biomass exceeding the control by 1.18 times in vivo and 1.28 times in vitro. In vitro, co-cultivation circumstances also led to an increase in the rate of utilization of nutritional medium. In comparison to the control, the amount of bacoside increases to 100% in vivo after a month of co-cultivation and 33% in vitro after 3 months.

Conclusions
In the present investigation, in vivo co-cultivation showed a favorable interaction effect on biomass production as well as bacoside content, which can satisfy the raw material demands of Brahmi plants in pharmaceutical industries.
Diagnosis, treatment, and prevention of community-acquired pneumonia in children: an evidence-based clinical practice guideline adapted for the use in Egypt using ‘Adapted ADAPTE’
Authors: Hussien Shahenaz Mohamoud , Hamed Tarek , Mohamed Magda Hassab Allah , Rashad Mohamed Mahmoud , Elnady Hala Gouda , Metwally Hoda M. Salah El Din , Refay Amira S. El , Sobh Bahaa Mohammed , Fouda Eman Mahmoud , Shaaban Hala Hamdi , Elattar Mona Mohsen , Mostafa Abla Saleh , Hamed Dina Hossam-Eldine , Samir Aya , Raffat Sally , Saeed Maysaa Abdallah , Kamel Nevin Abdalah , Hebish Sarah Naeem Bartella , Radwan Zeinab , Al Sawah Ahmed , Abd-Alkhalek Karima , Baky Ashraf Abdel , Omar Tarek E. I. , Amer Yasser S. , Sarhan Dina Tawfeek 
Published: November 2023

Abstract
Background
We recently adapted a guideline for Community-Acquired Pneumonia (CAP) in children to the Egyptian health system. Adaptation of evidence-based clinical practice guidelines to the local healthcare context is a valid alternative to de novo development that can upgrade their application without enforcing a major burden on resources. The objective of this manuscript is to elucidate diagnosis, treatment, and prevention of CAP as well as methods used for the adaptation process to produce the 1st National Guideline for Community-Acquired Pneumonia in children in Egypt using Adapted ADAPTE method. The full process was described extensively with all three phases of set up, adaptation, and finalization. An adaptation group and an external review including clinical content experts and methodologists conducted the process.

Results
The authors adapted 10 principal categories of recommendations from three source Clinical Practice Guidelines. Recommendations incorporate; common clinical manifestations, indications for hospitalization and intensive care unit admission, indications for laboratory investigations and radiology in diagnosis, choice of empiric antibiotic therapy in the outpatient and hospitalized children with non-complicated CAP and the duration of therapy, the role of influenza antiviral therapy, follow-up anticipated response to therapy, management of non-responding pneumonia, criteria of safe discharge, and prevention of CAP. Many tools were gathered and established to improve implement ability containing two clinical algorithms for management of non-complicated CAP and for non-responding pneumonia in children, pathway for assessment of severity of CAP in primary care facilities, medication tables, simplified Arabic patient information, PowerPoint slide presentation lecture for management of CAP, and online resources.

Conclusion
The final clinical guideline supports pediatricians and related healthcare workers with evidence-based applicable guidance for managing community-acquired pneumonia in Egypt. This work demonstrated the efficiency of Adapted ADAPTE and highlighted the importance of a cooperative clinical and methodological professional group for adaptation of national guidelines.
Social media psychology and mental health
Authors: Ahmed Jaafar Omer 
Published: November 2023

AbstractSocial networks have become a part of individual lives nowadays, and most of the world’s population participates and has accounts on different social networks. This is a new phenomenon specific to the twenty-first century, as a subject entirely related to the human mind in terms of psychology and psychiatry is at the beginning of research. This study aims to provide a psychological interpretation of social networking issues.The motives for using social networks are summarized within five main motivations: affinity, human needs, self-expression, information acquisition, and personal utility. Individuals use these networks as a source to hide their true personalities and show imaginary and desirable personalities. Despite the enjoyment of networks, individuals face two major risks: revenge porn and online bullying. Online social networks have many effects and dangers on individual mental health, so excessive use causes depression, anxiety, violence, addiction, and body image distortions in individuals. Although researchers focus on the negative effects of social networks, they still have several benefits for individual health.