bluuebunny/crossref_metadata_2025_split huggingface dataset:
Levothyroxine malabsorption following sleeve gastrectomy
Authors: Gruneisen Elodie , Yang Ji Wei , Pasqua Melissa-Rosina 
Published: January 2025

Summary
Oral levothyroxine (LT4) is prescribed worldwide for hypothyroidism. Bariatric surgery for patients with obesity has shown a substantial, long-term weight loss and considerable improvement of obesity-related diseases. LT4 malabsorption represents a significant cause of refractory hypothyroidism, well known after malabsorptive bariatric surgery such as Roux-en-Y gastric bypass. However, few studies have shown an increase in oral LT4 needed after sleeve gastrectomy. We present a 47-year-old woman with class III obesity and a history of papillary thyroid cancer, with an excellent biochemical and structural response after total thyroidectomy and radioactive iodine. She underwent sleeve gastrectomy 3 years later and developed refractory hypothyroidism despite taking high doses of oral LT4 and ensuring compliance. The T4 absorption test confirmed gastrointestinal LT4 malabsorption. She was initiated on intramuscular LT4 and oral T3 (liothyronine) with improving symptoms and levels of thyroid-stimulating hormone.

Learning points

Monitoring thyroid function tests is essential after bariatric surgery, including sleeve gastrectomy.

Oral LT4 malabsorption should be considered in cases of refractory hypothyroidism.

The T4 absorption test is a useful tool for distinguishing true malabsorption from pseudo-malabsorption.

Decreased LT4 absorption after bariatric surgery might be explained by higher gastric pH and reduced stomach volume (impaired dissolution) and by interference with food, vitamin/mineral supplements or other drugs.

When LT4 malabsorption is confirmed, a trial of other oral formulations (LT4 tablet crushed, soft gel or liquid preparation) or parenteral administrations is suggested.
ВЛИЯНИЕ ГУСЕОБРАЗНЫХ ПТИЦ НА ФИТО- И ЗООПЛАНКТОН ОЗЕР ПОЛУОСТРОВА ТАЙМЫР
Authors: КРЫЛОВ А.В. , ШАРОВ А.Н. , АНУФРИЕВА Т.Н. , САБИТОВА Р.З. , ЧАЛОВА И.В. , ГЛАДЫШЕВ М.И. 
Published: January 2025

Полученные данные о качественном и количественном составе летнего фито- и зоопланктона двух озер п-ова Таймыр свидетельствуют о более высоком трофическом статусе водоема, испытывающего нагрузку со стороны гидрофильных птиц. По сравнению с фоновым водоемом здесь зарегистрированы статистически значимо большие численность фитопланктона (134,6 ± 16,3 тыс. кл./л против 60,4 ± 11,8 тыс. кл./л), биомасса зоопланктона (349,0 ± 170,2 мг/л против 64,5 ± 19,5 мг/л), биомасса коловраток (15,6 ± 3,5 мг/л против 1,6 ± 0,4 мг/л) и их доминирование, а также индекс сапробности (1,71 ± 0,09 против 1,48 ± 0,06). Одновременно выявлены специфические черты организации сообществ этого водоема - более высокое видовое богатство фито- и зоопланктона; отсутствие в составе фитопланктона Cyanobacteriaи статистически значимо более высокие численность Bacillariophyta (80,7 ± 11,8 тыс. кл./л против 31,7 ± 6,5 тыс. кл./л), число видов (4 против 2) и биомасса (326,6 мг/л против 60,6 ± 18,8 мг/л) веслоногих ракообразных, что может определяться особенностями реакции гидробионтов на продукты жизнедеятельности птиц. Это позволяет говорить о перспективах гуанотрофикации для повышения трофического статуса водоемов без значимого ухудшения качества среды и биологического разнообразия сообществ гидробионтов.
The data obtained on the qualitative and quantitative composition of summer phyto- and zooplankton of two lakes of the Taimyr Peninsula indicate a higher trophic status of the water body, which is under pressure from hydrophilic birds. Compared to the background water body, statistically significantly higher phytoplankton abundance (134.6 ± 16.3 thousand cells/l vs. 60.4 ± 11.8 thousand cells/l), zooplankton biomass (134.6 ± 16.3 thousand cells/l vs. 60.4 ± 11.8 thousand cells/l), zooplankton biomass (349.0 ± 170.2 mg/l vs. 64.5 ± 19.5 mg/l), rotifer biomass (15.6 ± 3.5 mg/l vs. 1.6 ± 0.4 mg/l) and their dominance, as well as saprobic index (1.71 ± 0.09 vs. 1.48 ± 0.06). At the same time, specific features of community organization were revealed - higher species richness of phyto- and zooplankton; absence of Cyanobacteria in phytoplankton composition and statistically significantly higher abundance of Bacillariophyta (80.7 ± 11.8 thousand kl./l vs. 31.7 ± 6.5 thousand kl./l), number of species (4 vs. 2) and biomass (326.6 mg/l vs. 60.6 ± 18.8 mg/l) of paddle-bearing crustaceans, which may be determined by the peculiarities of hydrobionts reaction to the products of bird activity. This allows us to speak about the prospects of guanotrophication to improve the trophic status of water bodies without significant deterioration of environmental quality and biodiversity of hydrobiont communities.
Prescription Stimulant Dispensing to US Children: 2017–2023
Authors: He Sijia , Esteban McCabe Sean , Conti Rena M. , Volerman Anna , Chua Kao-Ping 
Published: January 2025

OBJECTIVE
To evaluate changes in prescription stimulant dispensing to children aged 5 to 17 years associated with the COVID-19 pandemic and the shortage of immediate-release mixed amphetamine salts (Adderall), which was announced in October 2022.

METHODS
We analyzed the 2017 to 2023 IQVIA Longitudinal Prescription Database, which captures 92% of US prescriptions. Using an interrupted time series design, we evaluated level and slope changes in the monthly stimulant-dispensing rate (number of children with stimulant dispensing per 100 000 children) in March 2020 and October 2022.

RESULTS
In March 2020, the monthly stimulant-dispensing rate to children declined −454.9 children per 100 000 (95% CI, −572.6 to −337.2), an 18.8% decrease relative to January 2017. After March 2020, this rate increased to 12.7 children per 100 000 per month (95% CI, 6.6–18.8). In October 2022, there was no level change (−39.7 children per 100 000; 95% CI, −189.9 to 110.5) or slope change (−12.1 children per 100 000 per month; 95% CI, −27.5 to 3.3), although estimates were negative. During October 2022, there was a level decrease in the monthly dispensing rate for immediate-release mixed amphetamine salts and a level increase in the monthly dispensing rate for dexmethylphenidate.

CONCLUSIONS
Stimulant dispensing to children declined after the pandemic began. Dispensing may also have declined after October 2022, but estimates were not significant, partly because decreased dispensing of immediate-release mixed amphetamine salts was offset by increased dispensing of other stimulants. Findings suggest the shortage may have prompted children to switch to alternative stimulants. Future research should evaluate whether any switches led to adverse events.
Economía circular y bioeconomía, pilares del desarrollo sostenible
Authors: Martinez Riascos Carlos Arturo 
Published: January 2025

Durante millones de años los procesos naturales se han ajustado para alcanzar un equilibrio dinámico: el agua se evapora para formar nubes que se precipitan como lluvia y llevan agua a los lugares más recónditos del planeta, luego vuelve a evaporarse para continuar su ciclo; así mismo, los seres vivos acumulan materia orgánica durante su crecimiento, la cual retorna al ambiente después de su muerte; de esa forma, todos los procesos naturales logran un balance para mantener el frágil equilibrio.
Estandarización de un protocolo de micropropagación de Passiflora maliformis L (PASSIFLORACEAE) a partir de semillas y segmentos nodales
Authors: Castrillón Toscano Ana Milena , Hernández Rendón Cesar Augusto , González Jaime Elena Paola , Restrepo Betancur Luis Fernando 
Published: January 2025

En Colombia, la producción frutícola ha avanzado debido a la creciente demanda de frutas tropicales, entre las cuales se destaca la cholupa (Passiflora maliformis L.), una especie endémica con potencial comercial. Sin embargo, la falta de información agronómica y material vegetal uniforme, ha limitado su expansión en el mercado. Este estudio, se centró en establecer un protocolo de propagación in vitro para la cholupa, utilizando semillas y segmentos nodales. Se realizaron tres tratamientos de desinfección de semillas, resultando el tratamiento 3 con etanol 70% por 2 minutos y NaClO 2.5% por 15 minutos con 2 gotas de Tween 20® con la mayor efectividad (77%). Para los segmentos nodales, el tratamiento 2 con 2 g L-1 de Benomyl® por 15 minutos, Isodine® 3%, NaClO 2% por 10 minutos y 2 gotas de Tween 20® mostró un 67% de efectividad, destacando el uso de Benomyl® para el control de hongos. En la etapa de establecimiento, tanto las semillas como los segmentos nodales se sembraron en el medio de cultivo MS (1962). La germinación de semillas fue del 100% para el tratamiento sin hormonas y para los tratamientos con 1 mg/L-1 de BAP y con 1 mg/ L-1 K, observándose más brotes con K. Los segmentos nodales mostraron un 80% de efectividad en crecimiento con 1 mg/L-1 de K. Ambos, semillas y segmentos nodales, demostraron buena capacidad de regeneración y respuesta a la propagación in vitro. Este protocolo, establece una base para la obtención de material vegetal homogéneo y de alta calidad, contribuyendo a la valorización y expansión comercial de la cholupa en Colombia y potencialmente en mercados internacionales.
Use of camrelizumab in treatment of nasopharyngeal carcinoma
Authors: Alymov Yu. V. , Mudunov A. M. , Romanov I. S. , Pkheshkhova B. G. 
Published: January 2025

Nasopharyngeal carcinoma is a rare pathology. It develops in the nasopharyngeal mucosa and is characterized by aggressive (recurrent and metastatic) progression. Due to complicated location, this disease is often diagnosed at late stages and requires systemic therapy. Due to the rareness of nasopharyngeal carcinoma, until recently there were no studies on modern drug therapy of this pathology with high evidence level.Aim. To describe the capabilities and mechanism of action of camrelizumab in nasopharyngeal carcinoma. The results of studies investigating the mechanism of action of camrelizumab were analyzed. The effectiveness of this drug in progression of nasopharyngeal cancer with previous chemotherapy and in combination with chemotherapy as the 1st line treatment of recurrent and / or metastatic process was evaluated. Based on the phase II trial results, the use of camrelizumab in patients with disease progression during standard chemotherapy allows to achieve progression-free survival of 8.5 months. Data obtained in the phase III trial demonstrated clinical benefit of adding this drug to standard chemotherapy in the 1st line therapy of recurrent and / or metastatic nasopharyngeal carcinoma: median progressionfree survival significantly increased from 6.9 to 9.7 months.Therefore, camrelizumab is a modern highly effective immunotherapeutic drug designed to treat patients with nasopharyngeal carcinoma.
Selpercatinib – a new option for a precision approach to the treatment of medullary thyroid cancer
Authors: Plugar A. K. , Severskaya N. V. , Isaev P. A. , Panaseykin Yu. A. , Polkin V. V. , Vatina L. N. , Agababyan T. A. , Ivanov S. А. , Kaprin A. D. 
Published: January 2025

Introduction. Multikinase inhibitors are used to treat nonresectable locally advanced and/or metastatic medullary thyroid cancer (MTC). However they are characterized by high toxicity associated with kinase inhibition. Selective RET inhibitor selpercatinib demonstrates high selectivity and tolerance which makes it a promising agent for MTC treatment.Aim. To evaluate selpercatinib effectiveness and tolerance in patients with metastatic MTC associated with a mutation in the RET gene.Materials and methods. The study included 9 patients with metastatic MTC and mutation in the RET gene who received treatment with selpercatinib 160 mg 2 times a day. The drug effectiveness was evaluated every 2–3 months based on the results of multispiral computed tomography of the whole body and tumor marker (calcitonin and carcinoembryonic antigen) levels.Results. Median duration of therapy was 29 months overall response rate was 78 %; complete response was observed in 56 % of patients. After 12 months of therapy progression-free survival was 100 %; after 24 months it was 89 %. Persistent decrease in calcitonin level (by more than 90 %) was achieved in all patients. The most common adverse events were arterial hypertension and insignificant creatinine increase.Conclusion. The results of therapy show significant improvement in the rate of objective response and progression[1]free survival which makes selpercatinib a preferential treatment choice in this category of patients.
Laboratory animals anesthesia recommendations for biomedical research purposes
Authors: Ryzhkov I. A. , Vasyutina M. L. , Dolgikh V. T. , Kazemirchuk M. S. , Kuzovlev A. N. , Murashova L. A. , Balabanova K. M. , Silachev D. N. , Soloveva V. V. , Sedko V. A. , Kornyushenkov E. A. 
Published: January 2025

Anesthesia is widely used in experimental biomedical research to anesthetize and immobilize laboratory animals during surgical interventions and experimental procedures. In contrast to clinical and veterinary anesthesiology, an important aspect of anesthesia in laboratory animals is to minimize the effect of anesthetics on the results of the study. On November 19, 2022, the IV Scientific and Practical Conference “Experimental Surgery, Anesthesiology and Reanimatology of Laboratory Animals” was held in Moscow, where the community of specialists in the field of laboratory animal science, experimental surgery, pathophysiology, veterinary medicine, clinical and veterinary anesthesiology discussed various aspects of anesthesia in laboratory animals. This review is based on the conference proceedings and is devoted to general issues of animal anesthesia, its technological aspects (methods, equipment and consumables), consideration of advantages and disadvantages of the most commonly used inhalation and injection anesthetics.The advantages and schemes of modern combined anesthesia are substantiated, in particular, the need for adequate intraoperative analgesia and the possibility of regional anesthesia. The use of obsolete and non-recommended drugs is also discussed. The review and recommendations have a practical orientation and are intended for biomedical researchers who use laboratory animals in basic, translational and regulated preclinical studies.
Adaptacja i postrzeganie imigrantów w państwach europejskich
Authors: Adamski Jakub Krzysztof 
Published: January 2025

Książka porusza problematykę migracji, koncentrując się na czynnikach mających wpływ na proces adaptacji imigrantów do społeczeństwa przyjmującego oraz na kształtowanie się określonego nastawienia do przybyszów wśród jego członków. Przedstawiono w niej szeroki historyczny, teoretyczny i polityczny kontekst współczesnej mobilności międzynarodowej w Europie. Zaprezentowane wyniki analiz obejmują porównania w czasie i przestrzeni, pokazując: co wpływa na poziom zaadaptowania imigrantów i nastawienie do nich członków społeczeństw przyjmujących, jak oba te elementy są ze sobą powiązane oraz jaką rolę mogą odgrywać w ich kształtowaniu się wydarzenia i charakterystyki poziomu makro. Na podkreślenie zasługuje również zastosowanie stosunkowo nowego podejścia analitycznego polegającego na stworzeniu syntetycznego wskaźnika do pomiaru adaptacji imigrantów. Całość tworzy złożony i wielowymiarowy obraz doświadczenia migracji w Europie na początku XXI wieku, wyłaniający się z analiz ilościowych. Książka ta powinna zainteresować przedstawicieli nauk społecznych, w szczególności zaś socjologów i specjalistów z obszaru studiów nad współczesnymi migracjami, jak również pracowników administracji, którzy w swojej pracy zawodowej mierzą się z kwestiami związanymi z migracją.
Mobile phone applications used to monitor age-related macular degeneration
Authors: Rogalska Anna , Kurzak Ewa 
Published: January 2025

WprowadzenieZwyrodnienie plamki żółtej związane z wiekiem (<i>age-related macular degeneration</i> – AMD) jest główną przyczyną utraty wzroku u osób starszych. Celem badania była analiza praktycznej wartości dostępnych aplikacji mobilnych służących do monitorowania AMD.Materiał i metodyW okresie od 1 do 31 marca 2023 r. przeprowadzono analizę ilościową i jakościową aplikacji na smartfony – dostępnych w języku polskim i angielskim w sklepie Google Play – z użyciem słów kluczowych „zwyrodnienie plamki żółtej związane z wiekiem” i „AMD”. Analiza obejmowała cztery kryteria jakościowe, oceniane w skali od 0 do 2 punktów każde: 1) możliwość monitorowania choroby, 2) ochrona danych użytkownika, 3) dostępność instrukcji ustnych oraz 4) użyteczność aplikacji. Na podstawie łącznej liczby punktów wyróżniono pięć poziomów jakości aplikacji: bardzo wysoki (8 pkt), wysoki (7 pkt), średni (6 pkt), poniżej średniego (5 pkt) oraz niski (≤ 4 pkt). Okulista przetestował każdą aplikację spełniającą kryteria włączenia.WynikiSpośród 249 zidentyfikowanych aplikacji tylko 14 spełniło kryteria włączenia do analizy. Spośród nich dwie scharakteryzowano jako bardzo wysokiej jakości, trzy jako wysokiej jakości (żadna z nich nie była w języku polskim), jedną jako średniej jakości i osiem jako niskiej jakości. Tylko dwie z 14 aplikacji odpowiadały potrzebom pacjentów z AMD, takim jak ograniczenia widzenia i stosowanie instrukcji ustnych.WnioskiDostępne aplikacje w języku polskim nie oferowały żadnej wartości dodanej w porównaniu z tradycyjnym papierowym testem Amslera. Aby aplikacje mobilne skutecznie pomagały w monitorowaniu AMD, należy nadać priorytet kluczowym aspektom, takim jak dostępność (najlepiej bezpłatna) i jakość, w tym bezpieczeństwo danych. Utworzenie zespołów ewaluacyjnych, w których skład weszliby eksperci medyczni, specjaliści ds. IT i przedstawiciele pacjentów, usprawniłoby rozwój i ocenę aplikacji mobilnych ukierunkowanych na monitorowanie AMD.
The Influence of Reading Corner Utilization on Students' Literacy Skill: An Experimental Study at Elementary School
Authors: Lutfiyyah Ningtyas  , Rintis Rizkia Pangestika  , Nur Ngazizah  
Published: January 2025

This study aims to analyze the effect of the use of reading corners on the literacy skills of elementary school students. This study uses a quantitative research method Pre-Experimental Design with the type of One-Group Pretest-Postest Design. The subjects of this study were all fifth grade students of Bajangrejo State Elementary School, totaling 12 students. The data collection technique was in the form of a test. The sample used was the total sample. The data analysis used was in the form of descriptive statistics, normality tests, homogeneity tests and parametric statistical hypothesis tests. in paired form sample t- test using SPSS 26. The results of this study obtained an average pretest value of 43.33 and a posttest of 71.25. Based on the results of the hypothesis test using Paired Sample T- Test obtained information that the calculated t value obtained -5.786 > t table 2.20099 and the significance value in the Sig column. (2-tailed) 0.000 which means 0.000 < 0.05, then it can be concluded that H1 is accepted and H0 is rejected. This study shows that the use of reading corners has a positive and significant influence on the literacy skills in Elementary School.
Crosstalk: Biochemical Signatures and Clinical Implications in Rare Hereditary Hemolytic Anemias (Hereditary Spherocytosis)
Authors: Al Toub Faris Abdoullah , Hamzah Obaied Asseri Amer , Rafi Baig Mirza , R. Almalki Naif Abdullaha , Anwar Firoz 
Published: January 2025

Background:
Clinical Hereditary Hemolytic Anemia (HAA) particularly Hereditary Spherocytosis
(HS) encompasses diverse genetic disorders causing premature red blood cell destruction and intrinsic RBC defects. There’s a pressing need for standardized diagnostic protocols tailored to the Asian population, particularly in Saudi Arabia, underscoring the significance of thorough blood biochemistry analysis.

Materials and Methods:
A case-control prospective study was conducted at King Abdulaziz University, samples were obtained from King Fahad, hospital Jeddah, Saudi Arabia, serving a significant population, and
blood samples from 27 patients meeting ethical criteria for HHA and HS. Inclusion criteria included diagnosed
patients of any age and sex, while exclusion criteria encompass chronic infections, metabolic diseases, pregnancy, and lactation. Blood profiling was conducted following strict protocols, aiming to glean insights into patients’ management and therapeutic strategies. Despite an intended larger sample size, limitations in availability led to the inclusion of 27 patient analyses.

Results:
Among 27 participants, males comprised 59.3%, females 40.7%. Anemia types indicated 22.2% Type
1 (HHA) and 77.8% Type 3 (HS). Age groups (<30, 31-59, ≥60 years) highlighted HS prevalence, notably in
older individuals. Blood pressure analysis revealed age-related increases, especially in those over 60 with systolic BP (147.33 ± 9.86 mm/Hg) (p≤0.02) and diastolic BP (85.67 ± 9.01 mm/Hg) (p≤0.03) emphasizing agespecific monitoring. Temperature variations were noted across ages, significant in patients over 60 (35.93 ±
1.100C) (p≤0.09), indicating potential clinical relevance. Iron levels showed no age-related differences, while
Blood Urea Nitrogen (BUN) levels rose with age, particularly in those over 60 (35.83 ± 16.67 mm/dL)
(p≤0.04), suggesting age-related influence. Alkaline Phosphatase levels increased with age, especially in patients aged 31 to 59 (205.80±123.17IU/L)(p≤0.001), warranting further investigation. Similarly, Aspartate
Transferase levels rose with age, especially in patients aged 31 to 59 (134.69 ± 284.58 U/L) (p≤0.01),), underlining age-specific considerations. Notable differences in BUN (15.03 mm/dL and 29.06 mm/dL)and Aspartate Transferase (33.01 U/L and 115.66 U/L) levels were observed among different anemia types with no major significant alteration in LDH.

Conclusion:
The results suggest unique biochemical signatures with potential renal and hepatic implications,
underscoring the importance of biochemical assessment in managing hereditary hemolytic anemias, particularly HS.
The Efficacy of Oral Atorvastatin for Skin Toxicity in Breast Cancer Patients Undergoing Radiotherapy: A Randomized, Double-blind, Placebo-controlled Trial
Authors: Danesh Mahmonir , Ghasemi Arash , Hamzehgardeshi Zeinab , Charati Jamshid Yazdani , Hosseinimehr Seyed Jalal 
Published: January 2025

Introduction:
Most Breast Cancer (BC) patients undergoing Radiotherapy (RT) are potentially susceptible
to skin toxicity and prone to clinical symptom complaints. This study aimed to investigate the effect
of oral Atorvastatin (ATV) administration on skin toxicity in BC patients undergoing RT.

Methods:
One hundred BC patients were randomly assigned to oral ATV (40 mg) or placebo tablets two days
before beginning the RT until the eighth week of the RT regimen was completed. Radiation-induced dermatitis
was classified according to the Radiation Therapy Oncology Group (RTOG) criteria for eight weeks of
treatment. In addition, during the eight weeks of RT, the clinical symptoms, such as pain, itching, burning, and
sensitivity, were scored by patients in both groups according to the Visual Analogue Scale (VAS).

Results:
Ninety-four BC patients were analyzed in this study. At the end of the seventh week of RT, the between-
group analysis showed a statistically significant reduction of 20.7% in the ATV group (1.693 ± 0.846)
compared to the placebo group (1.900 ± 0.986, P=0.036). However, the comparison of the dermatitis grade in
the ATV and placebo groups showed a reduction of 54.5% in the ATV group; this difference was not statistically
significant (p = 0.072). The results of VAS regarding the clinical symptoms of patients showed pain, itching,
burning, and sensitivity to touch to be clinically decreased in the ATV group compared to the placebo
group in the 8 weeks, but these differences were not statistically significant.

Conclusion:
According to the results of this clinical study, the oral administration of ATV at a dose of 40 mg
during RT regimens can effectively reduce skin RT-induced toxicity and improve the self-report clinical symptoms
among BC patients.