bluuebunny/crossref_metadata_2025_split huggingface dataset:
Foods and beverages made from Mexican Purple Corn: a means to increase anthocyanins’ intake
Authors: Mendoza-Mendoza Carmen Gabriela , Soto-Hernánde Ramón Marcos , Mendoza-Castillo Ma. del Carmen , Delgado-Alvarado Adriana , Sánchez-Ramírez Francisco Javier 
Published: November 2023

Background: Anthocyanins (AAs) are natural pigments and bioactive compounds that are of broad interest due to their potential beneficial effects on health. In the market, while some foods, such as berries, provide important amino acid (AA) intakes, there is a growing trend to explore new sources. In Mexico, there is the Mexican Purple Corn, a variant capable to produce AAs in all the organs of the corn ear. We overlook that the preparation of foods and beverages from these raw materials may represent the development of potential functional foods and a means to increase the dietary intake of AAs. Methods: We used spectrophotometry to quantify the total anthocyanins content (TAC) of three foods made from purple kernels, and six beverages prepared from corn husks+corncobs or corn silks. Foods consisted of elote (Mexican street corn or corn on a cob), a snack, and tortillas, while beverages involved what we named functional beverages, infusions, and hot teas. We compared their TAC values and estimated the AAs intake. Results: Foods and beverages exhibited total antioxidant capacities (TACs) ranging from 3.0 mg to 119.5 mg per 100 g of biomass (p ≤ 0.05). Notably, most beverages demonstrated higher TACs than foods. The corn husks+corncobs infusion recorded the highest TAC, succeeded by functional beverages derived from amino acid (AA) extracts of corn husks+corncobs (67.04 and 93.12 mg of TAC per 100 g of biomass, p ≤ 0.05). Among hot teas and infusions, maceration in the latter resulted in a higher AA extraction. For foods, TACs varied from 4.3 to 38.4 mg of TAC per 100 g of biomass, and, similar to beverages, the preparation process influenced TAC. The roasted snack exhibited a higher AA content. Conclusion: Mexican Purple Corn shows promise as a source for foods and beverages rich in amino acids (AAs). This crop represents an option to increase the daily intake of this flavonoid, and to acquire its potential bioactive effects. On a regular day, we can obtain 95 mg of TA from 300 g of purple corn-based foods, and 750 mL of different beverages made from corn husks, corncobs, and corn silks. Keywords: Mexican Purple Corn, anthocyanins, corn husks, corncobs, corn silks, dietary source of anthocyanins.
Al-I'laam wal-Qiyam: 'Alaaqatu Ihlaalin am Inhilaalin? (الإعلام والقيم: علاقة إحلال أم انحلال؟)
Authors: Salhi Mostafa , SYAIKH ABDURRAHMAN SIDDIK BANGKA BELITUN ISKANDI IAIN , Yunus Ibrahim Aliyu 
Published: November 2023

This article attempts to shed light on the media’s relationship with the values that fall within the dialectic of influence and vulnerability, which is a stand-alone topic in media and communication science studies; within the framework of what is known as research studying the impact of media and communication on recipients.
After standing on the value imperative, which is witnessing increasing interest in various research fields due to its importance and its existential nature, this imperative that is related to the nature of functions it undertakes within society, we moved to talk about the problem of values and the limits of convergence and nullity between them, highlighting the inability to judge the progress and backwardness of cultures.
We then moved on to talking about intellectual and taste alienation, identity disorder and value degeneration fueled by the media, which contributed greatly to penetration or cultural invasion, in the absence of awareness of use, and fascination with the culture of others.
We finish by talking about the transition from the value of media to informing values in an attempt to root for moral modernity, and to adopt a strategy that seeks to replace values instead of their dissolution.
يحاول هذا المقال تسليط الضوء على علاقة الإعلام بالقيم التي تندرج ضمن جدلية التأثير والتأثر، وهو موضوع مستقل في دراسات الإعلام وعلوم الاتصال في إطار ما يعرف بالبحث الذي يدرس تأثير الإعلام والاتصال على المستفيدين.
بعد الوقوف على حتمية القيمة، التي تشهد اهتمامًا متزايدًا بمجالات البحث المختلفة نظرًا لأهميتها وطبيعتها الوجودية، هذه الضرورة المرتبطة بطبيعة الوظائف التي تقوم بها داخل المجتمع، انتقلنا للحديث عن مشكلة القيم و حدود التقارب والتلاغي بينهما، وإبراز عدم القدرة على الحكم على تقدم الثقافات وتخلفها.
ثم انتقلنا للحديث عن الاغتراب الفكري والذوقي، واضطراب الهوية وانحطاط أو انحلال القيمة الذي يغذيه الإعلام، مما يساهم بشكل كبير في الاختراق أو الغزو الثقافي، في ظل غياب الوعي بالاستخدام، والانبهار بثقافة الآخرين.
ننتهي بالحديث عن الانتقال من قيمة الإعلام إلى القيم الإعلامية في محاولة للتجذير من أجل الحداثة الأخلاقية، واعتماد استراتيجية تسعى إلى إحلال القيم بدلاً من انحلالها.
Aura, una actualización de la imagen femenina medieval expuesta en el tratado Sentencias sobre amor
Authors: Pizarro Maite 
Published: November 2023

Este ensayo plantea para Aura, de Carlos Fuentes, una entrada de lectura según la cual la imagen de mujer hechicera constituye el reajuste contemporáneo de la femineidad demoniaca expuesta en el tratado medieval Sentencias sobre amor, de Francisco de Villalobos; y, además, invoca ciertos elementos duales que componen el espíritu alegórico del periodo antes señalado. Ante todo, se considera que el discurso se construye como un mosaico de citas y que estas citas, a su vez, tienen el potencial infinito de ramificarse en la actitud o disposición de lectura, ya que la obra es entendida como esqueleto o esquema que debe ser completado por la intención del destinatario. Interesa, en última instancia, vincular al mundo latinoamericano contemporáneo con ciertos aspectos del universo medieval europeo para recordar que el ser humano siempre camina y establece diálogos con sus propias huellas.
Tetraploid embryo aggregation produces high-quality blastocysts with an increased trophectoderm in pigs
Authors: Lee Joohyeong , Cai Lian , Kim Mirae , Choi Hyerin , Oh Dongjin , Jawad Ali , Lee Eunsong , Hyun Sang-Hwan 
Published: November 2023

Tetraploid complementation is an ideal method for demonstrating the differentiation potential of pluripotent stem cells. In this study, we selected the most efficient tetraploid production method for porcine embryos and investigated whether tetraploid blastomere aggregation could enhance the quality of tetraploid embryos. Three methods were investigated to produce tetraploid embryos: First, tetraploid embryos were produced using electro-fusion of two-cell stage parthenogenetic blastomere (FUTP). Second, somatic cell was injected into the mature oocyte and fused to produce tetraploid embryos. Third, oocytes were matured with Cytochalasin B (CB) for the late 22 h of in vitro maturation to inhibit the first polar body (PB1). Following that, non-PB1 oocytes were treated with CB for 4 h after parthenogenetic activation. There was no significant difference in the blastocyst development rate and tetraploid production rate of the embryos produced through the three methods. However, FUTP-derived blastocysts had a significantly lower percentage of apoptotic cells compared to other methods. The developmental competence of embryos, expression of trophectoderm cell marker genes, and distribution of YAP1 protein were investigated in tetraploid embryos produced using the FUTP method. The FUTP method most effectively prevented apoptosis during porcine tetraploid embryo formation. Tetraploid aggregation-derived blastocysts have a high proportion of trophectoderm with increased expression of the CDX2 mRNA and high YAP1 intensity. High-quality blastocysts derived from a tetraploid embryo aggregation can serve as suitable source material for testing the differentiation potential of pluripotent stem cells for blastocyst complementation in pigs.
High oral carriage of multidrug resistant Gram-negative bacilli in adolescents: the SOPKARD-Junior study
Authors: Katkowska Marta , Garbacz Katarzyna , Kwapisz Ewa , Suligowska Klaudia , Kusiak Aida , Cichońska Dominika , Świetlik Dariusz 
Published: November 2023

IntroductionThe colonization of the oral cavity by potentially pathogenic antimicrobial-resistant bacteria in adolescents and its consequences is very poorly understood. The present study focused on the occurrence of oral colonization by Gram-negative bacilli (GNB) and their multidrug resistance, including the production of extended-spectrum β-lactamases (ESBLs) and carbapenemases, among healthy adolescents and risk factors associated with GNB colonization.Materials and methodsThis study was conducted as part of “A program for the early detection of risk factors for lifestyle diseases SOPKARD-Junior” (SOPKARD-Junior). Oral samples were collected from 182 adolescents from four public elementary schools in Sopot, Poland, aged 13-14 years. Bacterial strains were identified by the MALDI-TOF MS method. Screening of antimicrobial resistance was performed using a disk diffusion method. The NG-Test® CARBA-5 was used to detect and differentiate the five most widely distributed carbapenemases. Demographic and clinical data were collected and statistical analysis of risk factors was performed.ResultsA total of 68 out of 182 (37.4%) healthy adolescents was documented oral colonization with Gram-negative bacilli, including 50/182 (27.5%) multidrug resistant (MDR-GNB) strains. Over 60% of oral carriage concerned three main genera Enterobacter spp., Pseudomonas spp., and Serratia spp., which were detected in 22.1%, 19.1%, and 19.1% of participants, respectively. Citrobacter spp., Escherichia coli, Klebsiella spp., Hafnia spp., Aeromonas spp., Acinetobacter spp., and Stenotrophomonas spp. were also isolated. The antimicrobial resistance to ampicillin (100%), ceftazidime (69.1%), meropenem (60.3%), gentamycin (60.3%), piperacillin/tazobactam (52.9%), and piperacillin (45.6%) were the most common. Among 73.5% GNB strains multidrug resistance was observed, including all Pseudomonas spp. strains. Among MDR-GNB, 30.4% were resistant to four groups of antibiotics, half of the MDR Pseudomonas spp. strains were resistant to 10 groups of antibiotics. Extended-spectrum β-lactamases were produced by Enterobacter cloacae, Klebsiella spp., and Serratia spp. (7.4%). Colonization by ESBLs-positive GNB strains was significantly associated with recurrent respiratory infections, nasal congestion, and bronchitis (p&lt;0.05).ConclusionOur study revealed high oral carriage of multi-drug resistant Gram-negative bacilli in healthy adolescents and the association of ESBL-producing strains with respiratory infections. Further studies on oral colonization with GNB are necessary due to the possibility of distinct infections and the acquisition of antibiotic resistance by resident microbiota.
Muscarinic acetylcholine receptors M2 are upregulated in the atrioventricular nodal tract in horses with a high burden of second-degree atrioventricular block
Authors: Nissen Sarah Dalgas , Saljic Arnela , Carstensen Helena , Braunstein Thomas Hartig , Hesselkilde Eva Melis , Kjeldsen Sofie Troest , Hopster-Iversen Charlotte , D’Souza Alicia , Jespersen Thomas , Buhl Rikke 
Published: November 2023

BackgroundSecond-degree atrioventricular (AV) block at rest is very common in horses. The underlying molecular mechanisms are unexplored, but commonly attributed to high vagal tone.AimTo assess whether AV block in horses is due to altered expression of the effectors of vagal signalling in the AV node, with specific emphasis on the muscarinic acetylcholine receptor (M2) and the G protein-gated inwardly rectifying K+ (GIRK4) channel that mediates the cardiac IK,ACh current.MethodEighteen horses with a low burden of second-degree AV block (median 8 block per 20 h, IQR: 32 per 20 h) were assigned to the control group, while 17 horses with a high burden of second-degree AV block (median: 408 block per 20 h, IQR: 1,436 per 20 h) were assigned to the AV block group. Radiotelemetry ECG recordings were performed to assess PR interval and incidence of second-degree AV block episodes at baseline and on pharmacological blockade of the autonomic nervous system (ANS). Wenckebach cycle length was measured by intracardiac pacing (n = 16). Furthermore, the expression levels of the M2 receptor and the GIRK4 subunit of the IKACh channel were quantified in biopsies from the right atrium, the AV node and right ventricle using immunohistochemistry and machine learning-based automated segmentation analysis (n = 9 + 9).ResultsThe AV block group had a significantly longer PR interval (mean ± SD, 0.40 ± 0.05 s; p &lt; 0.001) and a longer Wenckebach cycle length (mean ± SD, 995 ± 86 ms; p = 0.007) at baseline. After blocking the ANS, all second-degree AV block episodes were abolished, and the difference in PR interval disappered (p = 0.80). The AV block group had significantly higher expression of the M2 receptor (p = 0.02), but not the GIRK4 (p = 0.25) in the AV node compared to the control group. Both M2 and GIRK4 were highly expressed in the AV node and less expressed in the atria and the ventricles.ConclusionHere, we demonstrate the involvement of the m2R-IK,ACh pathway in underlying second-degree AV block in horses. The high expression level of the M2 receptor may be responsible for the high burden of second-degree AV blocks seen in some horses.
Bibliometric and visual analysis of intraoperative hypotension from 2004 to 2022
Authors: Wang Jieyan , Liu Zile , Bai Yawen , Tian Guijie , Hong Yinghao , Chen Guo , Wan Yantong , Liang Hui 
Published: November 2023

BackgroundIntraoperative hypotension (IOH) is a common complication occurring in surgical practice. This study aims to comprehensively review the collaboration and impact of countries, institutions, authors, journals, keywords, and critical papers on intraoperative hypotension from the perspective of bibliometric, and to evaluate the evolution of knowledge structure clustering and identify research hotspots and emerging topics.MethodsArticles and reviews related to IOH published from 2004 to 2022 were retrieved from the Web of Science Core Collection. Bibliometric analyses and visualization were conducted on Excel, CiteSpace, VOSviewer, and Bibliometrix (R-Tool of R-Studio).ResultsA total of 1,784 articles and reviews were included from 2004 to 2022. The number of articles on IOH gradually increased in the past few years, and peaked in 2021. These publications were chiefly from 1,938 institutions in 40 countries, led by America and China in publications. Sessler Daniel I published the most papers and enjoyed the highest number of citations. Analysis of the journals with the most outputs showed that most journals concentrated on perioperative medicine and clinical anesthesiology. Delirium, acute kidney injury and vasoconstrictor agents are the current and developing research hotspots. The keywords “Acute kidney injury”, “postoperative complication”, “machine learning”, “risk factors” and “hemodynamic instability” may also become new trends and focuses of the near future research.ConclusionThis study uses bibliometrics and visualization methods to comprehensively review the research on intraoperative hypotension, which is helpful for scholars to better understand the dynamic evolution of IOH and provide directions for future research.
Blood pressure variability, nocturnal heart rate variability and endothelial function predict recurrent cerebro-cardiovascular events following ischemic stroke
Authors: Filchenko Irina , Mürner Nicolas , Dekkers Martijn P. J. , Baillieul Sebastien , Duss Simone B. , Brill Anne-Kathrin , Horvath Thomas , Heldner Mirjam R. , Rexhaj Emrush , Bernasconi Corrado , Bassetti Claudio L. A. , Schmidt Markus H. 
Published: November 2023

IntroductionCardiovascular parameters characterizing blood pressure (BP), heart rate (HR), endothelial function and arterial stiffness predict cerebro-cardiovascular events (CCVE) in the general population. Considering the paucity of data in stroke patients, we assessed these parameters as potential predictors of recurrent CCVE at acute stroke stroke.Patients and methodsThis is a secondary outcome analysis of a prospective observational longitudinal Sleep Deficiency &amp; Stroke Outcome Study (ClinicalTrials.gov Identifier: NCT02559739). The study consecutively recruited acute ischemic stroke patients. Cardiovascular parameters (blood pressure variability [BPV], heart rate variability [HRV], endothelial function, and arterial stiffness) were assessed within the first week post-stroke. Future CCVE were recorded over a 3-year follow-up. Multivariate Cox regression analysis was used to investigate the prognostic value of 48 cardiovascular parameters regarding CCVE risk.ResultsOut of 447 recruited patients, 359 were included in this analysis. 20% of patients developed a future CCVE. A high variability of systolic BP (n = 333) and nocturnal HR (non-linear parameters; n = 187) at acute stroke predicted CCVE risk after adjustment for demographic parameters, cardiovascular risk factors and mean BP or HR, respectively. Endothelial dysfunction (n = 105) at acute stroke predicted CCVE risk after adjustment for age and sex, but not after adjustment for cardiovascular risk factors. Diurnal HR and arterial stiffness at acute stroke were not associated with CCVE risk.ConclusionHigh blood pressure variability, high nocturnal HRV and endothelial function contribute to the risk for future CCVE after stroke.
Immunohistochemistry-derived subtypes of breast cancer distribution in four regions of Ethiopia
Authors: Belachew Esmael Besufikad , Desta Adey Feleke , Gebremariam Tewodros Yalew , Deneke Dinikisira Bekele , Ashenafi Senait , Yeshi Melisachew Mulatu , Fenta Bizunesh Dires , Alem Alemwosen T/Hayimanot , Alemu Addisu , Abafogi Abdo Kedir , Desta Tigist , Chanyalew Menberework , Beshah Daniel , Taylor Lesley , Bauer Marcus , Tsehay Dareskedar , Girma Selfu , Melka Daniel Seifu , Tessema Tesfaye Sisay , Kantelhardt Eva J. , Howe Rawleigh 
Published: November 2023

PurposeDifferent biological characteristics, therapeutic responses, and disease-specific outcomes are associated with different molecular subtypes of breast cancer (BC). Although there have been different studies on BC in the Ethiopian capital city of Addis Ababa, there have been few studies in other parts of the nation, and none have evaluated biological characteristics in other locations in the context of the extensive ethnic and genetic diversity found in Ethiopia. This study was carried out to evaluate the distribution of immunohistochemistry (IHC) subtypes of BCs throughout four Ethiopian regions.MethodsA total of 227 formalin-fixed paraffin-embedded (FFPE) tissue blocks were collected from tertiary hospitals in four Ethiopian regions between 2015 and 2021. The IHC staining was performed for subtyping, ER, PR, HER2, and Ki-67 proliferation markers.ResultsThe mean age at diagnosis was 43.9 years. The percentage of ER and PR-negative tumors were 48.3% and 53.2%, respectively. The IHC subtypes showed the following distribution: 33.1% triple-negative breast cancer (TNBC), 27.6% luminal B, 25.2% luminal A, and 14.1% HER2 enriched. In multiple logistic regression analysis, grade III and HER2 positivity were associated with larger tumor size, and also originating from Jimma compared to Mekele.ConclusionPatients with ER-negative, PR-negative, and TNBC were found in 48.3%, 53.2%, and 33.1% of cases, respectively, showing that half the patients could potentially benefit from endocrine treatment. A considerably high prevalence of TNBC was reported in our study, demanding additional research that includes genetic predisposition factors. Additionally, aggressive tumors were found in a high percentage of younger age groups, which must be considered when planning personalized treatment strategies.
Experimental study on impact of high voltage power transmission lines on silicon photovoltaics using artificial neural network
Authors: Javed Muhammad Rameez , Hussain Muhammad Imtiaz , Usman Mudassar , Asghar Furqan , Shahid Muhammad , Amjad Waseem , Lee Gwi Hyun , Waleed Aashir 
Published: November 2023

The recent trend of renewable energy has positioned solar cells as an excellent choice for energy production in today’s world. However, the performance of silicon photovoltaic (PV) panels can be influenced by various environmental factors such as humidity, light, rusting, temperature fluctuations and rain, etc. This study aims to investigate the potential impact of high voltage power transmission lines (HVTL) on the performance of solar cells at different distances from two high voltage levels (220 and 500 KV). In fact, HVTLs generate electromagnetic (EM) waves which may affect the power production and photocurrent density of solar cells. To analyze this impact, a real-time experimental setup of PV panel is developed (using both monocrystalline and polycrystalline solar cells), located in the vicinity of 220 and 500 KV HVTLs. In order to conduct this study systematically, the impact of HVTL on solar panel is being measured by varying the distance between the HVTL and the solar panels. However, it is important to understand that the obtained experimental values alone are insufficient for comprehensive verification under various conditions. To address this limitation, an Artificial Neural Network (ANN) is employed to generate HVTL impact curves for PV panels (particularly of voltage and current values) which are impractical to obtain experimentally. The inclusion of ANN approach enhances the understanding of the HVTL impact on solar cell performance across a wide range of conditions. Overall, this work presents the impact study of HVTL on two different types of solar cells at different distances from HVTL for two HV levels (i.e., 220 and 500 KV) and the comparison study of HVTL impact on both monocrystalline and polycrystalline solar cells.