bluuebunny/crossref_metadata_2025_split huggingface dataset:
Brain-inspired multimodal motion and fine-grained action recognition
Authors: Li Yuening , Yang Xiuhua , Chen Changkui 
Published: January 2025

IntroductionTraditional action recognition methods predominantly rely on a single modality, such as vision or motion, which presents significant limitations when dealing with fine-grained action recognition. These methods struggle particularly with video data containing complex combinations of actions and subtle motion variations.MethodsTypically, they depend on handcrafted feature extractors or simple convolutional neural network (CNN) architectures, which makes effective multimodal fusion challenging. This study introduces a novel architecture called FGM-CLIP (Fine-Grained Motion CLIP) to enhance fine-grained action recognition. FGM-CLIP leverages the powerful capabilities of Contrastive Language-Image Pretraining (CLIP), integrating a fine-grained motion encoder and a multimodal fusion layer to achieve precise end-to-end action recognition. By jointly optimizing visual and motion features, the model captures subtle action variations, resulting in higher classification accuracy in complex video data.Results and discussionExperimental results demonstrate that FGM-CLIP significantly outperforms existing methods on multiple fine-grained action recognition datasets. Its multimodal fusion strategy notably improves the model's robustness and accuracy, particularly for videos with intricate action patterns.
Clinical efficacy of Tuina therapy combined with traditional Chinese exercises in the treatment of symptomatic lumbar disc herniation: a multicentre randomised controlled trial protocol
Authors: Fan Zhihong , Jia Shenghong , Zhou Xin , Li Chao , Shao Jiahao , Liu Xiaofeng , Liao Yitao , Xu Yenan , He Dandan , Wu Shixiang , Zhang Xian 
Published: January 2025

BackgroundLow back pain and lower extremity sensory and functional abnormalities are common symptoms of lumbar disc herniation (LDH), which can easily cause walking dysfunction and significantly impair the quality of life of patients. Tuina and traditional Chinese exercises (TCEs) are effective in relieving pain and restoring dysfunction, and both are often used in China as a combination of passive therapy and active exercise to ease symptoms in patients with LDH. However, the majority of current clinical trials on the treatment of LDH with Tuina or TCEs are single-centre clinical studies, and the quality of these studies is generally low. Furthermore, clear evidence of clinical efficacy as to whether Tuina combined with TCEs is superior to single TCEs for improving dysfunction and pain in patients with LDH is lacking.Methods/designThe design is a multicentre, assessor-blinded clinical randomised controlled trial. A total of 166 patients with LDH (aged 18–65 years) were recruited from four centres and randomly assigned at a 1:1 ratio to two groups: the TCE group and the Tuina combined with the TCE group. Each group received three treatments over the course of 1 week for a total of 4 weeks. The primary outcome indicator was the Oswestry Disability Index, whereas the secondary outcome indicators were the Short Form of Quality of Life Scale, the Short-Form McGill Pain Questionnaire Scale, and gait analysis. Assessments were made before the treatment, at the end of the treatment, and at the third and sixth months’ follow-ups. Gait analysis was only used for comparison between the two groups before and after treatment, and did not involve follow-up. Adverse events occurring during the trial were faithfully recorded.ConclusionThe results of this study are expected to provide a more effective research protocol for symptomatic LDH and an evidence-based rationale for the efficacy and safety of Tuina combined with TCEs in the treatment of symptomatic LDH.Clinical trial registrationhttps://www.chictr.org.cn/showproj.html?proj=209956, identifier ChiCTR2300077361.
Burden of diet-related chronic diseases in Chinese and Japanese adults attributable to dietary risk factors from 1990 to 2021: a systematic analysis of the Global Burden of Disease Study 2021
Authors: Wang Minyan , Ma Huan , Qin Chu , Mandizadza Oscar Onayi , Ni Haojie , Shi Yun , Ji Conghua 
Published: January 2025

BackgroundChronic diseases are a major cause of death, contributing significantly to the global disease burden. The growing aging population and chronic disease burden in China and Japan have a substantial impact on health outcomes. Dietary factors, as key modifiable elements, are particularly important. Therefore, we aimed to analyze and compare the impact of dietary factors on the burden of chronic diseases in China and Japan and to develop measures to reduce this burden.MethodsAccording to the WHO classification of chronic diseases, we selected cardiovascular diseases, neoplasms, and diabetes for analysis. We collected relevant data from the GBD database, described and analyzed the disease burden by age, gender, and year, and created bar and trend charts. We conducted a comparative analysis of the dietary factors influencing these three chronic diseases by generating heatmaps. The joinpoint model was used to analyze the time trends of these three diseases from 1990 to 2021.ResultsFrom 1990 to 2021, the burden of neoplasms and cardiovascular diseases in China and Japan declined to varying degrees, while the burden of diabetes continued to increase. The main dietary risk factor for neoplasms is a high red meat diet, while for cardiovascular diseases, a high-sodium diet, especially in China. In addition, high meat consumption appears to serve as a protective factor for both Chinese and Japanese populations. Regarding dietary risk factors for diabetes, China is associated with a high red meat diet, whereas Japan is characterized by a high-processed meat diet.ConclusionBy comparing the burden of chronic diseases related to dietary factors in China and Japan, this study proposes strategies for national healthy diets, such as reducing sodium, processed meat, and red meat intake and increasing whole grains, vegetables, and fruit intake. In addition, attention should be given to the dietary status of the elderly, along with targeted health education initiatives.
A clinical study of minimal blood flow clamping combined with 3D printing technology in laparoscopic nephron-sparing surgery
Authors: Yang Lingbo , Wei Pengtao , Li Xiaohui , Sun Jiantao 
Published: January 2025

ObjectiveTo compare the safety and effectiveness of minimum flow clamping combined with 3D printing technology and highly selective renal artery clamping in laparoscopic nephron-sparing surgery.MethodsFifty-two patients with renal cancer undergoing partial resection admitted to Luoyang Central Hospital Affiliated with Zhengzhou University from 2018-01 to 2021-12 were randomly divided into two groups. Group A comprised 30 cases that underwent laparoscopic partial nephrectomy by minimal blood flow clamping combined with 3D printing technology. Group B comprised 22 cases that underwent laparoscopic partial nephrectomy by highly selective renal artery clamping technology. The operation time, renal artery branch clamping time, intraoperative blood loss, postoperative renal function injury, and complication rate were compared between the two groups.ResultsThe operation time, blood loss, renal function injury, and complication rate of Group A were shorter than those of Group B (p &lt; 0.05). The time of renal artery clamping in Group B was shorter than that in Group A (p &lt; 0.05). There was no statistical significance in the positive rate of resection margin between the two groups (p &gt; 0.05).ConclusionsIn laparoscopic nephron-sparing surgery, minimum blood flow clamping technology not only can meet the requirements of accurate tumor resection but also can maximize the preservation of residual renal function, greatly shorten the operation time, reduce the amount of blood loss, and reduce the incidence of perioperative complications, making it worthy of promotion in clinical work. Clinical Trial Registration: [website], identifier [registration number].
Benefit from regular versus leakage-related exchange of voice prostheses in patients post-laryngectomy considering complication rates and patient satisfaction feedback—a randomized case−controlled trial
Authors: Żurek Michał , Czesak Małgorzata , Majszyk Daniel , Rzepakowska Anna 
Published: January 2025

ObjectiveThe complications related to voice prosthesis usage substantially affect the physical and social functioning of patients after total laryngectomy, which influences their quality of life. Leakage dysfunction is the most common, causing uncertainty and requiring unscheduled hospital visits. Our study was designed to estimate the benefit of regular versus leakage-related replacement of the voice prosthesis. Study Design. Randomized case−controlled trials. Setting. Tertiary hospital.MethodsThe study included patients who underwent total laryngectomy with primary voice prosthesis insertion between 2020 and 2021 and were randomly assigned to one of two arms: regular exchange (REA) every 3 months or leakage-dependent exchange (LEA). The control treatment was continued for 12 months. The primary outcome measure was the comparison of complication rates in both arms, including periprosthetic leakage, granulation or atrophy of mucosa around the fistula, and dislocation of the prosthesis. The secondary outcome measures were the mean number of exchanges per year and patient satisfaction.ResultsThirty-six patients continued the study according to the protocol, with 16 in REA and 20 in LEA. A total of 153 voice prostheses were replaced during the study period, including 98 in REA and 55 in LEA. Comparative analysis of REA and LEA revealed a significantly longer time between replacements in the LEA group (p = 0.023) and a significantly lower rate of complications in the REA group (p = 0.029). Periprosthetic leakage was the most common complication associated with the use of voice prostheses, occurring in 3.06% of patients in REA and 9.09% in LEA, but this difference was statistically insignificant (p = 0.137). The analysis of factors predisposing patients to leakage failure revealed that treatment schemes, concomitant diseases, dental conditions, and diet or alcohol consumption significantly affect the longevity of voice prostheses. The relative and absolute risks (RRR and ARR) of complications in the REA group were reduced by 69.39% and 13.88%, respectively. The number of replacements (NNTs) that should be performed in the REA scheme to prevent one complication over the LEA scheme is 721.ConclusionThe replacement of regular voice prostheses improved the overall complication rate over the scheme based on leakage demand; however, it did not yield superior benefits in terms of patient satisfaction or economic aspects.Clinical Trial Registrationhttps://clinicaltrials.gov/study/NCT04268459, identifier NCT04268459.
Mucosal snare resection-endoscopic submucosal excavation for gastric submucosal tumors: a retrospective study (with video)
Authors: Wei Wei , Zheng Xiaolong , Ye Yongli , Li Hongxia , Hong Yiping , Cai Jianting 
Published: January 2025

AimsThis study aimed to compare the clinical outcomes of patients with submucosal tumors treated with endoscopic submucosal excavation (ESE) and those treated with mucosal snare resection-endoscopic submucosal excavation (MSR-ESE).MethodsWe retrospectively analyzed clinical data from patients who underwent ESE or MSR-ESE at the Second Affiliated Hospital of Zhejiang University School of Medicine between January 2023 and January 2024. Factors such as operation time, intraoperative perforation, postoperative adverse events, postoperative fasting time, antibiotic use, hospitalization duration, costs, and pathological diagnosis were compared between the two procedures.ResultsA total of 180 patients with submucosal tumors were included in this study. The MSR-ESE group consisted of 75 patients (41.7%), while the ESE group had 105 patients (58.3%). Propensity score matching (PSM) showed no significant differences in postoperative antibiotic use, fasting time, or intraoperative perforation between the two groups (P&gt;0.05). However, the MSR-ESE group demonstrated shorter operation and hospitalization times, lower hospitalization costs, and a reduced incidence of postoperative peritonitis (P&lt;0.05). Multivariate logistic regression analysis identified operation time as an independent risk factor for unplanned intraoperative perforation, with the likelihood of perforation increasing significantly as operation time increased (P=0.007, OR=1.015, 95% CI, 1.004 to 1.026).ConclusionMSR-ESE outperforms ESE with shorter operation times, lower costs, and fewer postoperative complications, making it a safe and effective treatment for gastric submucosal tumors.
Identification of new candidate genes for the hereditary predisposition to uveal melanoma: IGCMU trial
Authors: Godiveau Mélanie , Ginzac Angeline , Bidet Yannick , Ponelle-Chachuat Flora , Privat Maud , Durando Xavier , Cavaillé Mathias , Lepage Mathis 
Published: January 2025

IntroductionUveal melanoma (UM) is a rare ocular cancer. While germline mutations in genes such as BAP1 and MBD4 account for approximately 20% of familial UM cases, the hereditary factors underlying the remaining cases remain unknown. Epidemiological studies have suggested an increased risk of prostate cancer, thyroid cancer, and leukemia among patients with UM, indicating potential unidentified genetic predispositions. This study aims to identify new candidate genes associated with a hereditary predisposition to UM.MethodsThis single-center study, conducted at Centre Jean Perrin, will involve the exome sequencing of 50 patients with UM who do not harbor known pathogenic variants in the BAP1 or MBD4 genes. The primary objective is to identify novel candidate genes associated with hereditary cancer predisposition among UM patients. A several-step-bioinformatic analysis will be conducted to identify the genes of interest. A secondary objective is to explore genes known to be involved in predisposition to other cancers, already described in the occurrence of uveal melanoma, but where an association has not been fully established yet. The study has begun in October 2024, with patient recruitment lasting 12 months. No follow-up period is planned, but the duration of the genetic analyses is estimated at six months, with the final study report expected by October 2026.DiscussionThe identification of novel hereditary predisposition genes for UM could significantly enhance genetic counselling and surveillance strategies for families affected. This study could also contribute to a better understanding of the genetic landscape of UM, potentially leading to more personalized and effective options for its detection.Trial registrationClinicalTrials.gov, identifier NCT06550674, registered in August 2024. Protocol: version 1.0, January 18th, 2024.
Cost-effectiveness analysis of gumarontinib versus savolitinib for the treatment of advanced or metastatic NSCLC with MET exon 14 skipping mutations in China using partitioned survival model
Authors: Fang Gang , Pi Zhipeng , An Yiping , Cao Xinxin , Li Wei , Zhu Xiangjun , Ding Jinxi 
Published: January 2025

Background and objectivesBoth gumarontinib and savolitinib have demonstrated efficacy in treating non-small-cell lung cancer (NSCLC) with tumors harboring mesenchymal–epithelial transition factor gene exon 14 (METex14) skipping. However, the comparison of their efficacy and pharmacoeconomics profiles remains limited. This study aims to evaluate the cost-effectiveness of gumarontinib versus savolitinib for the treatment of METex14 skipping NSCLC in China.MethodsA 3-state partitioned survival model (PSM) was developed with lifetime horizon from the perspective of Chinese healthcare system. Survival inputs were based on an unanchored matching-adjusted indirect comparison using individual patient data from GLORY trial to adjust for patient characteristics in NCT02897479. Costs and outcomes were discounted at an annual rate of 5%. Sensitivity and scenario analyses were conducted to explore model uncertainty.ResultsGumarontinib gained an additional 0.10 QALYs at an incremental cost of $1,893 compared to savolitinib, resulting in the ICERs of $19,243/QALY, which is below the threshold of 3 times the GDP per capita in China ($35,007 per capita in 2022). Sensitivity and scenario analyses confirmed the robustness of the base-case results.ConclusionGumarontinib is a cost-effective option compared to savolitinib for METex14 skipping NSCLC in China.
Qinggan Yipi capsule ameliorates hepatic fibrosis in rats by down-regulating the TGF-β1/Smad2/3 signaling pathway and improving gut microbiota imbalance
Authors: Xue Wenjing , Liu Haiqing , Su Ziheng , Wang Siqi , Cheng Junping , Pan Yunzhi , Zhang Lurong 
Published: January 2025

Background and objectiveQinggan Yipi Capsule (QgYp) is a hospital preparation that has been used for many years in the treatment of chronic liver diseases. However, the mechanism of QgYp in ameliorating hepatic fibrosis (HF) remains unclear. This study aims to clarify the anti-liver fibrosis effect of QgYp and its mechanism of action.MethodsThis study uses a carbon tetrachloride (CCl4) induced HF rat model and TGF-β1 stimulated HSC-T6 cell line (rat HSCs) as experimental models. The therapeutic effects were evaluated through pathology, biochemical tests, and ELISA. The therapeutic mechanism of QgYp for HF was predicted through network pharmacology. The expression of TGF-β1/Smad2/3 related proteins was detected by qPCR analysis and Western blot analysis. The composition of the gut microbiota was analyzed using 16S rRNA gene sequencing.ResultsHistopathological analysis, serum biochemical tests, and ELISA measurements showed that QgYp effectively decreased the levels of ALT, AST, HA, LN, PCIII, and IV-C while improving collagen deposition and hepatocyte necrosis. Protein-protein interaction (PPI) network analysis screened HF-related genes, including peroxisome proliferator-activated receptor gamma (PPARG), tumor necrosis factor (TNF), and TGF-β1. GO and KEGG analyses indicated that QgYp significantly affects TGF-β signaling pathway. In addition, the results of qPCR and Western blot analysis from both in vitro and in vivo experiments indicated that QgYp significantly downregulated the expression of proteins and mRNA associated with the TGF-β1/Smad2/3 pathway. The 16S rDNA gene sequencing results showed that QgYp can increase the diversity and richness of the gut microbiota in HF rats and alter the composition of the gut microbiota.ConclusionQgYp could effectively ameliorate HF, and this effect might be connected to the downregulation of the TGF-β1/Smad2/3 pathway, the suppression of HSCs activation, and regulation of gut microbiota dysbiosis.
Self-medication and knowledge of pregnant women about the use of medication during pregnancy in the cities of Rijeka and Zadar, Croatia
Authors: Jovanović Željko , Vulić Petra 
Published: January 2025

ObjectivesPregnancy is a sensitive period during which the use of medicines, whether by prescription or self-medication, is a major challenge as it can have a significant impact on the health of the mother and the development of the foetus. It is important that pregnant women are well-informed about potential risks and benefits and seek advice from healthcare professionals before taking any medication, including over-the-counter medications, to ensure the safety and health of themselves and their unborn child. The aim of this study was to analyse the self-medication practices of pregnant women and their knowledge and attitudes toward medicines in the context of pregnancy. This includes analysing the way pregnant women make decisions about self-medication and their awareness of potential risks and benefits.MethodsA cross-sectional study was conducted on a sample of pregnant women from two cities of similar size and status, Zadar and Rijeka, in the period from 1 May 2023 to 1 June 2023 at the Clinical Hospital Centre Rijeka and the General Hospital Zadar.ResultsOf the 128 women interviewed, 56% were taking prescription medication, most frequently in Rijeka, while 69.5% practised self-medication. The most commonly used medications were dietary supplements—75 (44.88%); over-the-counter pain relievers and fever, cough, allergy, cold, and nausea remedies—42 (33.07%); and herbal medicines—8 (6.29%).ConclusionPregnant women need to be better informed about self-medication and the safe use of medication. A total of 94.5% of respondents consider it important to improve educational programmes and access to information about the effects of medication on the health of the foetus and pregnancy outcomes.
How effective is the addition of specific exercise therapy for patients after anterior cruciate ligament surgery? A systematic review and meta-analysis
Authors: Zhou Hao , Qian Jia , Xing Yu-Mei , Cui Long , Bu Yi-Feng 
Published: January 2025

ContextAnterior cruciate ligament (ACL) injuries are prevalent in sports and often require surgical intervention followed by rehabilitation. Several rehabilitation methods have been used for patients after ACL surgery.ObjectiveThis study aimed to assess the overall efficacy of exercise therapy in improving outcomes for patients following ACL surgery using a systematic review and meta-analysis of randomized controlled trials (RCTs).Data sourcesPubMed, Web of Science, Embase, and the Cochrane Library were searched for randomized controlled trials published from 1 January 2000 to 30 August 2024. Study quality was assessed using the Cochrane Risk-of-Bias tool.Study selectionA total of 11 randomized controlled trials (whole-body vibration training = 4, core-stability training = 2, strength training = 3, blood flow restriction training = 1, and aquatic training = 1) involving 552 anterior cruciate ligament surgery patients were included.Data extractionTwo researchers individually screened the key information for each eligible study and evaluated the quality of the studies. Any dispute was discussed by a third researcher.ResultsCompared with conventional therapy, exercise therapy significantly reduced pain scores (mean difference: −0.53, 95% CI: −0.82 to −0.24, and p &lt; 0.001) and improved muscle strength (flexion: 13.76 and extension: 12.46) and knee function (effect size: 2.06 and p = 0.001). Secondary outcomes, although less pronounced, also demonstrated improvement.LimitationThe sources of heterogeneity among the included studies were not fully identified, particularly concerning variations in exercise protocols or patient characteristics. Additionally, the therapeutic effects of specific exercise modalities (e.g., strength training versus aquatic training) were not directly compared.ConclusionExercise therapy is effective in reducing pain, enhancing muscle strength, and improving knee function in ACL surgery patients. These findings underscore the importance of integrating tailored exercise therapies into rehabilitation programs.Systematic review registration numberhttps://www.crd.york.ac.uk/PROSPERO/, identifier registration number. CRD42023476653.