bluuebunny/crossref_metadata_2025_split huggingface dataset:
TREN PENELITIAN KETERTIBAN UMUM (PUBLIC ORDER): SEBUAH PENDEKATAN BIBLIOMETRIK
Authors: Rahmadanita Annisa 
Published: October 2023

Ketertiban umum merupakan kondisi di mana masyarakat berjalan dalam suasana yang aman, damai, dan teratur. Namun perkembangan mengenai ketertiban umum belum diketahui secara rinci. Kajian ini bertujuan untuk mengetahui tren penelitian di bidang ketertiban umum. Metode penelitian yang digunakan adalah paradigma kuantitatif dengan pendekatan bibliometrik. Peneliti menggunakan teknik purposive sampling dengan batasan Bahasa yang digunakan adalah Bahasa Inggris. Analisis co-word pada analisis bibliometrik yang digunakan oleh peneliti dalam menganalisis data. Analisis data juga menggunakan aplikasi VOSviewer. Temuan penelitian menunjukkan bahwa publikasi ilmiah dengan subjek “public order” pada pangkalan data Scopus sebanyak 2524 dokumen. Pada rentang tahun 1991-2023 dan dibatasi publikasi dengan Bahasa Inggris, tipe dokumen artikel, kata kunci public order, source type journal, dan subject area social sciences, terdapat sebanyak 103 dokumen. Terlihat bahwa jumlah publikasi mengalami peningkatan yang signifikan pada periode tahun 2015 hingga 2017. Tren paling tinggi dalam jumlah publikasi tercatat terjadi pada tahun 2022, dengan total 14 dokumen yang diterbitkan. Terdapat 2856 kata kunci, 25 di antaranya saling berhubungan dan dikelompokkan dalam 4 kluster. Kesimpulannya bahwa terdapat 25 kata kunci yang menjadi tren berdasarkan nilai occurance minimal 10 diantaranya adalah policing, police, freedom, right, event, paper, case, principle, violence, disorder, public space, use, role, international law, person, trend, concept question, threat, Russian federation, citizen, constitution, individual, human right. Kata kunci tersebut menjadi tren disebabkan beberapa faktor yaituadanya konteks sosial dan politik, kasus hukum dan peradilan, perkembangan teknologi dan informasi serta hak asasi manusia dan kebebasan. Topik-topik penelitian terkait dengan konteks sosial dan politik, kasus hukum dan peradilan, perkembangan teknologi dan informasi serta hak asasi manusia dan kebebasan, direkomendasikan untuk penelitian selanjutnya. Perlu dilakukan kajian mendalam dan berkelanjutan terkait topik-topik yang menjadi tren tersebut. Adapun topik "russian federation”, "citizen," "constitution," "individual," dan "human right" memiliki potensi untuk dieksplorasi dalam penelitian mendatang.Kata Kunci: Analisis Kata Kunci, Bibliometrik, Ketertiban Umum, Scopus.
First-principles study of Li-doped planar g-C3N5 as reversible H2 storage material
Authors: Chen Xihao , Liu Zonghang , Cheng Jiang , Li Jiwen , Guo Donglin , Zhang Liang , Niu Xianghong , Wang Ning , Wang Guangzhao , Gao Peng 
Published: October 2023

Under the background of energy crisis, hydrogen owns the advantage of high combustion and shows considerable environment friendliness; however, to fully utilize this novel resource, the major hurdle lies in its delivery and storage. The development of the in-depth yet systematical methodology for two-dimensional (2D) storage media evaluation still remains to be challenging for computational scientists. In this study, we tried our proposed evaluation protocol on a 2D material, g-C3N5, and its hydrogen storage performance was characterized; and with addition of Li atoms, the changes of its electronical and structural properties were detected. First-principles simulations were conducted to verify its thermodynamics stability; and, its hydrogen adsorption capacity was investigated qualitatively. We found that the charges of the added Li atoms were transferred to the adjacent nitrogen atoms from g-C3N5, with the formation of chemical interactions. Thus, the isolated metallic sites tend to show considerable electropositivity, and can easily polarize the adsorbed hydrogen molecules, and the electrostatic interactions can be enhanced correspondingly. The maximum storage capacity of each primitive cell can be as high as 20 hydrogen molecules with a gravimetric capacity of 8.65 wt%, which surpasses the 5.5 wt% target set by the U.S. Department of Energy. The average adsorption energy is ranged from −0.22 to −0.13 eV. We conclude that the complex 2D material, Li-decorated g-C3N5(Li@C3N5), can serve as a promising media for hydrogen storage. This methodology provided in this study is fundamental yet instructive for future 2D hydrogen storage materials development.
Role of Tau protein in long COVID and potential therapeutic targets
Authors: Marwaha Bharat 
Published: October 2023

IntroductionLong COVID is an emerging public health burden and has been defined as a syndrome with common symptoms of fatigue, shortness of breath, cognitive dysfunction, and others impacting day-to-day life, fluctuating or relapsing over, occurring for at least two months in patients with a history of probable or confirmed SARS CoV-2 infection; usually three months from the onset of illness and cannot be explained by an alternate diagnosis. The actual prevalence of long-term COVID-19 is unknown, but it is believed that more than 17 million patients in Europe may have suffered from it during pandemic.PathophysiologyCurrently, there is limited understanding of the pathophysiology of this syndrome, and multiple hypotheses have been proposed. Our literature review has shown studies reporting tau deposits in tissue samples of the brain from autopsies of COVID-19 patients compared to the control group, and the in-vitro human brain organoid model has shown aberrant phosphorylation of tau protein in response to SARS-CoV-2 infection. Tauopathies, a group of neurodegenerative disorders with the salient features of tau deposits, can manifest different symptoms based on the anatomical region of brain involvement and have been shown to affect the peripheral nervous system as well and explained even in rat model studies. Long COVID has more than 203 symptoms, with predominant symptoms of fatigue, dyspnea, and cognitive dysfunction, which tauopathy-induced CNS and peripheral nervous system dysfunction can explain. There have been no studies up till now to reveal the pathophysiology of long COVID. Based on our literature review, aberrant tau phosphorylation is a promising hypothesis that can be explored in future studies. Therapeutic approaches for tauopathies have multidimensional aspects, including targeting post-translational modifications, tau aggregation, and tau clearance through the autophagy process with the help of lysosomes, which can be potential targets for developing therapeutic interventions for the long COVID. In addition, future studies can attempt to find the tau proteins in CSF and use those as biomarkers for the long COVID.
Knowledge mapping of the relationship between norepinephrine and memory: a bibliometric analysis
Authors: Song Qi , Tan Yaqian 
Published: October 2023

IntroductionMemory is a fundamental cognitive function for successful interactions with a complex environment. Norepinephrine (NE) is an essential component of catecholamine induced by emotional arousal, and numerous studies have demonstrated that NE is a key regulator in memory enhancement. We therefore conducted a bibliometric analysis to represent the knowledge pattern of the literature on the theme of NE-memory relationship.MethodsThe WOSCC database was selected to extract literature published during 2003-2022. The collected data of annual production, global cooperation, research structure and hotspots were analyzed and visualized.ResultsOur results showed that research on the links between NE and memory displayed a considerable development trend over the last two decades. The USA had a leading position in terms of scientific outputs and collaborations. Meanwhile, University of California Irvine contributed the most publications. Benno Roozendaal and James McGaugh were the most prolific authors in this field, and Neurobiology of Learning and Memory had the highest number of publications on this topic. The research emphasis has evolved from memory-related diseases and brain regions to neural mechanisms for different types of memory at neural circuit levels.ConclusionOur bibliometric analysis systematically analyzed the literature on the links between NE and memory from a bibliometric perspective. The demonstrated results of the knowledge mapping would provide valuable insights into the global research landscape.
Analysis of risk factors for positive surgical margin after laparoscopic radical prostatectomy with and without neoadjuvant hormonal therapy
Authors: Wang Fangming , Zhang Gang , Tang Yuzhe , Wang Yunpeng , Li Jianxing , Xing Nianzeng 
Published: October 2023

BackgroundPositive surgical margins (PSM) is not only an independent risk factor for recurrence, metastasis, and prognosis, but also an important indicator of adjuvant therapy for prostate cancer (PCa) patients treated with radical prostatectomy (RP). At present, there are few reports analyzing risk factors of PSM in laparoscopic RP (LRP), especially for those PCa cases who accepted neoadjuvant hormonal therapy (NHT). Hence, the aim of the current study was to explore risk factors for PSM after LRP in PCa patients with and without NHT.MethodsThe clinicopathological data of patients who underwent LRP from January 2012 to July 2020 was retrospectively analyzed. Risk factors for PSM after LRP in NHT and non-NHT groups were respectively explored.ResultsThe overall PSM rate was 33.3% (90/270), PSM rate was 39.3% (64/163) in patients without NHT and 24.3% (26/107) in those with NHT. The apex was the most common location of PSM in non-NHT group (68.8%, 44/64), while the fundus was the most common location of PSM in NHT group (57.7%, 15/26). Multiple logistic regression revealed that body mass index (BMI), PSA, ISUP grade after LRP, pathological stage T (pT) and pathological lymph node status (pN) were independent factors affecting the PSM for patients without NHT (OR=1.160, 95%CI:1.034-1.301, p=0.011; OR=3.385, 95%CI:1.386-8.268, p=0.007; OR=3.541, 95%CI:1.008-12.444, p=0.049; OR=4.577, 95%CI:2.163-9.686, p&lt;0.001; OR=3.572, 95%CI:1.124-11.347, p=0.031), while pT, pN, and lymphovascular invasion (LVI) were independent risk factors affecting PSM for patients with NHT (OR=18.434, 95%CI:4.976-68.297, p&lt;0.001; OR=7.181, 95%CI:2.089-24.689, p=0.002; OR=3.545, 95%CI:1.109-11.327, p=0.033).ConclusionsThe apex was the most common location in NHT group, and BMI, PSA, ISUP after LRP, pT and pN were independent risk factors affecting PSM for NHT patients; while the fundus was the most common location in non-NHT group, and pT, pN, and LVI were independent risk factors affecting PSM for non-NHT patients.
NEUROD2 function is dispensable for human pancreatic β cell specification
Authors: Cota Perla , Saber Lama , Taskin Damla , Jing Changying , Bastidas-Ponce Aimée , Vanheusden Matthew , Shahryari Alireza , Sterr Michael , Burtscher Ingo , Bakhti Mostafa , Lickert Heiko 
Published: October 2023

IntroductionThe molecular programs regulating human pancreatic endocrine cell induction and fate allocation are not well deciphered. Here, we investigated the spatiotemporal expression pattern and the function of the neurogenic differentiation factor 2 (NEUROD2) during human endocrinogenesis.MethodsUsing Crispr-Cas9 gene editing, we generated a reporter knock-in transcription factor (TF) knock-out human inducible pluripotent stem cell (iPSC) line in which the open reading frame of both NEUROD2 alleles are replaced by a nuclear histone 2B-Venus reporter (NEUROD2nVenus/nVenus).ResultsWe identified a transient expression of NEUROD2 mRNA and its nuclear Venus reporter activity at the stage of human endocrine progenitor formation in an iPSC differentiation model. This expression profile is similar to what was previously reported in mice, uncovering an evolutionarily conserved gene expression pattern of NEUROD2 during endocrinogenesis. In vitro differentiation of the generated homozygous NEUROD2nVenus/nVenus iPSC line towards human endocrine lineages uncovered no significant impact upon the loss of NEUROD2 on endocrine cell induction. Moreover, analysis of endocrine cell specification revealed no striking changes in the generation of insulin-producing b cells and glucagon-secreting a cells upon lack of NEUROD2.DiscussionOverall, our results suggest that NEUROD2 is expendable for human b cell formation in vitro.
Invasion of fall armyworm, (Spodoptera frugiperda, J E Smith) (Lepidoptera, Noctuidae) on onion in the maize–onion crop sequence from Maharashtra, India
Authors: Soumia P. S. , Shirsat Dhananjay V. , Chitra N. , Guru-Pirasanna-Pandi Govindharaj , Karuppaiah Vadivelu , Gadge Ankush S. , Thangasamy Arunachalam , Mahajan Vijay 
Published: October 2023

IntroductionClimate change affects geographical distribution of insect pests which poses threats to the environment, as well as agricultural productivity and production worldwide. Spodoptera frugiperda is commonly known as fall armyworm (FAW), a potential insect pest of monocot crops like maize, wheat, rice and sorghum globally. Among these, maize is the most preferred host crop while worldwide there are very few reports on onion being a host of fall armyworm.MethodsThe fall armyworm (FAW) was identified by examining the morphological characteristics of its immature and mature stages, as well as by analyzing the mitochondrial cytochrome oxidase 1 (COX1) gene. Further, the strain identity was confirmed through multiple sequence alignment with previously identified S. frugiperda strains from corn and rice. Also studied the biology and damage symptoms caused by FAW in onion crops.ResultsDuring our experiments, the incidence of FAW ranged from 5 to 20 percent in different plots. The highest incidence was observed in young crops (30–45 days after transplanting) that were sown in November 2020. The FAW larvae exhibited six instars, with a total larval duration of 22.2 ± 0.37 days. The pest had multiple generations per year. The fully developed larvae formed earthen cocoons in the soil for pupation, with a pupal duration of 8.0 ± 0.45 days. The male adults had a recorded longevity of 6.4± 0.40days, while the female adults lived for approximately 9.2 ± 0.37 days. The COX1 gene sequencing revealed its 100% similarity with Spodoptera frugiperda and the comparison of sequences among FAW infecting rice and maize by using multiple sequence alignment showed differences at 11 positions.DiscussionThe present study is the first report of FAW invasion in onion in India and provides basic ideas about FAW characteristics which will help to control this new invasive pest in onion. In tropical regions with multiple cropping system and seasons, it becomes very important to investigate invasive pests as well as its host range in order to forecast its potential damage and devise suitable control measures.
A novel ΔNp63-dependent immune mechanism improves prognosis of HPV-related head and neck cancer
Authors: Mourtada Jana , Lony Christelle , Nicol Anaïs , De Azevedo Justine , Bour Cyril , Macabre Christine , Roncarati Patrick , Ledrappier Sonia , Schultz Philippe , Borel Christian , Burgy Mickaël , Wasylyk Bohdan , Mellitzer Georg , Herfs Michaël , Gaiddon Christian , Jung Alain C. 
Published: October 2023

BackgroundDeconvoluting the heterogenous prognosis of Human Papillomavirus (HPV)-related oropharyngeal squamous cell carcinoma (OSCC) is crucial for enhancing patient care, given its rapidly increasing incidence in western countries and the adverse side effects of OSCC treatments.MethodsTranscriptomic data from HPV-positive OSCC samples were analyzed using unsupervised hierarchical clustering, and clinical relevance was evaluated using Kaplan-Meier analysis. HPV-positive OSCC cell line models were used in functional analyses and phenotypic assays to assess cell migration and invasion, response to cisplatin, and phagocytosis by macrophages in vitro.ResultsWe found, by transcriptomic analysis of HPV-positive OSCC samples, a ΔNp63 dependent molecular signature that is associated with patient prognosis. ΔNp63 was found to act as a tumor suppressor in HPV-positive OSCC at multiple levels. It inhibits cell migration and invasion, and favors response to chemotherapy. RNA-Seq analysis uncovered an unexpected regulation of genes, such as DKK3, which are involved in immune response-signalling pathways. In agreement with these observations, we found that ΔNp63 expression levels correlate with an enhanced anti-tumor immune environment in OSCC, and ΔNp63 promotes cancer cell phagocytosis by macrophages through a DKK3/NF-κB-dependent pathway.ConclusionOur findings are the first comprehensive identification of molecular mechanisms involved in the heterogeneous prognosis of HPV-positive OSCC, paving the way for much-needed biomarkers and targeted treatment.
Associations of genetically predicted circulating levels of cytokines with telomere length: a Mendelian randomization study
Authors: Pan Renbing , Xiao Mingjia , Wu Zhigang , Liu Jingwen , Wan Lijun 
Published: October 2023

BackgroundTelomere length (TL) has been regarded as a biomarker of aging, and TL shortening is associated with numerous chronic illnesses. The mounting evidence has shown that inflammatory cytokines are involved in maintaining or shortening TL, the causality of cytokines with TL remains unknown. Therefore, we performed a two-sample Mendelian randomization (MR) analysis to estimate the underlying correlations of circulating inflammatory cytokines with TL.MethodsGenetic instrumental variables for inflammatory cytokines were identified through a genome-wide association study (GWAS) involving 8,293 European individuals. Summary statistics of TL were derived from a UK Bio-bank cohort comprising 472,174 samples of individuals with European descent. We employed the inverse-variance weighted (IVW) approach as our main analysis, and to ensure the reliability of our findings, we also conducted additional analyses including the weighted median, MR-Egger, MR pleiotropy residual sum and outlier test, and weighted model. Lastly, the reverse MR analyses were performed to estimate the likelihood of inverse causality between TL and the cytokines identified in the forward MR analysis. Cochran’s Q test were employed to quantify the degree of heterogeneity.ResultsAfter applying Bonferroni correction, a higher circulating level of Interleukin-7 (IL-7) was suggestively associated with TL maintaining (OR:1.01, 95%CI:1.00-1.02, P=0.032 by IVW method). The study also revealed suggestive evidence indicating the involvement of Interleukin-2 receptor, alpha subunit (IL-2Rα) level was negatively associated with TL maintaining (OR:0.98, 95%CI:0.96-1.00, P=0.045 by IVW method), and the weighted median approach was consistent (OR:0.99, 95%CI:0.97-1.00, P=0.035). According to the findings of reverse MR analysis, no significant causal relationship between TL and cytokines was explored. Our analysis did not reveal any substantial heterogeneity in the Single nucleotide polymorphisms or horizontal pleiotropy.ConclusionsOur MR analysis yielded suggestive evidence supporting the causality between circulating IL-7 and IL-2Rα and telomere length, necessitating further investigations to elucidate the mechanisms by which these inflammatory cytokines may impact the progression of telomeres.
Establishing the best combination of the kappa free light chain index and oligoclonal bands for an accurate diagnosis of multiple sclerosis
Authors: Monreal Enric , Fernández-Velasco José Ignacio , García-Soidán Ana , Sainz de la Maza Susana , Espiño Mercedes , Villarrubia Noelia , Rodríguez-Jorge Fernando , Chico-García Juan Luís , Sainz-Amo Raquel , Masjuan Jaime , Costa-Frossard Lucienne , Villar Luisa María 
Published: October 2023

IntroductionThe immunoglobulin kappa free light chain (KFLC) index has been proposed as a potentially suitable alternative to oligoclonal IgG bands (OCGB) for diagnosing multiple sclerosis (MS), offering automation and reduced processing time. However, there is no consensus on the preferred approach or how to combine both techniques.MethodsThis prospective cohort study aimed to determine the best utilization of OCGB and KFLC index in patients with a clinically isolated syndrome (CIS) followed for at least two years. OCGB and KFLC were assessed using isoelectric focusing and immunoblotting and turbidimetry, respectively. Sensitivity, specificity, and accuracy for diagnosing MS were calculated for each method.ResultsThe study included 371 patients, with 260 (70.1 %) being women, and a median age of 34.9 (27.8 – 43.9) years. Using a cut-off value of 6.1, the KFLC index demonstrated a sensitivity and specificity of 86.3% and 93.9%, respectively. The sensitivity of OCGB (95.3%) was higher (p &lt; 0.001 vs. KFLC index) and the specificity (100%) was comparable to that of the KFLC index (p = 0.5). The concordance between the methods was not uniform across all patients, with 97.8% agreement in patients with KFLC index ≥ 6.1 and 56.0 % in patients with KFLC index &lt; 6.1. In patients with a KFLC index &lt; 6.1, OCGB still identified 75.0 % of MS patients due to its higher sensitivity. An algorithm using the KFLC index as a screening tool and OCGB as an alternative for patients with a negative KFLC index result achieved an accuracy of 96.3 %.DiscussionCombining the KFLC index and OCGB can provide an easily reproducible and accurate method for diagnosing MS, with OCGB primarily reserved for patients with a KFLC index &lt; 6.1.
Ocean mixing induced by three-dimensional structure of equatorial mode tropical instability waves in the Pacific Ocean
Authors: Fang Liyuan , Ma Kai , Liu Chuanyu , Wang Xiaowei , Wang Fan 
Published: October 2023

Observations have revealed that tropical instability waves (TIWs) play an important role in the ocean mixing of the equatorial thermocline. However, most studies have not distinguished the individual effects from the TIWs’ two modes, and most of them focused on the effect of the TIW-induced vertical shear on the formation of mixing. In this study, we utilize the high-resolution ocean reanalysis data to isolate the 3D structure of the equatorial mode of TIW (eTIW) and examine the detailed mechanisms of its mixing effects. Horizontally, the temperature associated with the eTIWs shows a centrosymmetric structure in the upper layers, but vertically, the phase begins to transition at ~70 and becomes opposite to that of the upper layer below 90 m. The centrosymmetric temperature structure leads to a similar stratification pattern in the upper layers. We find that the pattern of the eTIW-associated reduced shear squared (RSS), an indicator for potential shear instability, is controlled by its stratification rather than shear, suggesting that the former plays a more important role than the latter in resulting in shear instability and mixing. Specifically, it is in the northern (southern) part of the clockwise (anticlockwise) phase of the eTIWs that the eTIW-associated RSS is positively large, where the total flow is more likely to be modulated by shear instability and mixing. Hence, the present study provides a new mechanism for the TIW-induced mixing in the equatorial thermocline. However, in specific regions where the eTIW-induced shear has the same sign as that of the mean flow, the eTIW-associated shear squared can also significantly enhance the total RSS and lead to shear instability, consistent with previous studies.