bluuebunny/crossref_metadata_2025_split huggingface dataset:
Long-term Exposure to Local but Not Inhalation Anesthetics Affects Neurite Regeneration and Synapse Formation between Identified Lymnaea Neurons
Authors: Onizuka Shin , Takasaki Mayumi , Syed Naweed I. 
Published: January 2005

Background
General and local anesthetics are used in various combinations during surgical procedures to repair damaged tissues and organs, which in almost all instances involve nervous system functions. Because synaptic transmission recovers rapidly from various inhalation anesthetics, it is generally assumed that their effects on nerve regeneration and synapse formation that precede injury or surgery may not be as detrimental as that of their local counterparts. However, a direct comparison of most commonly used inhalation (sevoflurane, isoflurane) and local anesthetics (lidocaine, bupivacaine), vis-a-vis their effects on synapse transmission, neurite regeneration, and synapse formation has not yet been performed.

Methods
In this study, using cell culture, electrophysiologic and imaging techniques on unequivocally identified presynaptic and postsynaptic neurons from the mollusc Lymnaea, the authors provided a comparative account of the effects of both general and local anesthetics on synaptic transmission, nerve regeneration, and synapse formation between cultured neurons.

Results
The data show that clinically used concentrations of both inhalation and local anesthetics affect synaptic transmission in a concentration-dependent and reversal manner. The authors provided the first direct evidence that long-term overnight treatment of cultured neurons with sevoflurane and isoflurane does not affect neurite regeneration, whereas both lidocaine and bupivacaine suppress neurite outgrowth completely. The soma-soma synapse model was then used to compare the effects of both types of agents on synapse formation. The authors found that local but not inhalation anesthetics drastically reduced the incidence of synapse formation. The local anesthetic-induced prevention of synapse formation most likely involved the failure of presynaptic machinery, which otherwise developed normally in the presence of both sevoflurane and isoflurane.

Conclusion
This study thus provides the first comparative, albeit preclinical, account of the effects of both general and local anesthetics on synaptic transmission, nerve regeneration, and synapse formation and demonstrates that clinically used lidocaine and bupivacaine have drastic long-term effects on neurite regeneration and synapse formation as compared with sevoflurane and isoflurane.
Remifentanil Preconditioning Confers Cardioprotection via Cardiac κ- and δ-Opioid Receptors
Authors: Zhang Ye , Irwin Michael G. , Wong Tak Ming , Chen Mai , Cao Chun-Mei 
Published: January 2005

Background
Remifentanil preconditioning (RPC) reduces the infarct size in anesthetized rat hearts, and this effect seems to be mediated by all three types of opioid receptors (ORs). Because there is evidence of only kappa- and delta- but not mu-ORs in the rat heart, the authors investigated whether RPC confers cardioprotection via cardiac kappa- and delta-OR as well as via extracardiac mu-OR agonist activity. The authors also investigated the involvement of signaling mechanisms, namely protein kinase C and mitochondrial adenosine triphosphate-sensitive potassium (KATP) channels.

Methods
The hearts of male Sprague-Dawley rats weighing 190-210 g were removed, mounted on a Langendorff apparatus, and perfused retrogradely at 100 cm H2O with Krebs-Ringer's solution. All hearts were subjected to 30 min of ischemia and 2 h of reperfusion. The study consisted of three series of experiments on the effect of ischemic preconditioning or RPC (10, 50, and 100 ng/ml remifentanil) after blockade of OR subtypes (delta-OR antagonist naltrindol, kappa-OR antagonist nor-binaltorphimine, and mu-OR antagonist CTOP). The involvement of protein kinase C or the KATP channel in the cardioprotection of RPC was also investigated using specific blockers in each group. RPC was produced by three cycles of 5-min perfusion of remifentanil in Krebs-Ringer's solution interspersed with a 5-min reperfusion with Krebs solution only. Infarct size, as a percentage of the area at risk, was determined by 2,3,5-triphenyltetrazolium staining.

Results
Infarct size as a percentage of the area at risk was significantly reduced after RPC from 51.9 +/- 5.0% (control, n = 8) to 36.2 +/- 10.0% (100 ng/ml RPC, n = 8, P < 0.01). This effect was stopped by pretreatment with naltrindol (52.3 +/- 5.2%) and nor-binaltorphimine (43.5 +/- 6.0%) but not CTOP (37.1 +/- 6.0%). Chelerythrine and GF109203X, both protein kinase C inhibitors, abolished the effects of RPC or ischemic preconditioning on infarct size as a percentage of area at risk. 5-Hydroxydecanoate (a selective mitochondrial KATP channel blocker) also abolished the cardioprotection of RPC and IPC, but HMR-1098 (a selective inhibitor of the sarcolemmal KATP channel) did not.

Conclusion
Cardiac delta- and kappa- but not mu-ORs mediate the cardioprotection produced by RPC. Both protein kinase C and the mitochondrial KATP channel were involved in this effect.
Action of Isoflurane on the Substantia Gelatinosa Neurons of the Adult Rat Spinal Cord
Authors: Wakai Ayako , Kohno Tatsuro , Yamakura Tomohiro , Okamoto Manabu , Ataka Toyofumi , Baba Hiroshi 
Published: January 2005

Background
Although isoflurane, a volatile anesthetic, can block the motor response to noxious stimulation (immobility and analgesia) and suppress autonomic responsiveness, how it exerts these effects at the neuronal level in the spinal cord is not fully understood.

Methods
The effects of a clinically relevant concentration (1 rat minimum alveolar concentration [MAC]) of isoflurane on electrically evoked and spontaneous excitatory/inhibitory transmission and on the response to exogenous administration of the gamma-aminobutyric acid type A receptor agonist muscimol were examined in lamina II neurons of adult rat spinal cord slices using the whole cell patch clamp technique. The effect of isoflurane on the action potential-generating membrane property was also examined.

Results
Bath-applied isoflurane (1.5%, 1 rat MAC) diminished dorsal root-evoked polysynaptic but not monosynaptic excitatory postsynaptic currents. Glutamatergic miniature excitatory postsynaptic currents were also unaffected by isoflurane. In contrast, isoflurane prolonged the decay phase of evoked and miniature gamma-aminobutyric acid type A receptor-mediated inhibitory postsynaptic currents and increased the amplitude of the muscimol-induced current. Isoflurane had little effect on action potential discharge activity.

Conclusions
Isoflurane augments gamma-aminobutyric acid-mediated inhibitory transmission, leading to a decrease in the excitability of spinal dorsal horn neurons. This may be a possible mechanism for the antinociceptive effect of isoflurane in the spinal cord.
Continuous Infusion of Ropivacaine for Pain Relief after Iliac Crest Bone Grafting for Shoulder Surgery
Authors: Blumenthal Stephan , Dullenkopf Alexander , Rentsch Katharina , Borgeat Alain 
Published: January 2005

Background
The aim of the study was to compare the efficacy of either ropivacaine or placebo through an iliac crest (IC) catheter after Bankart repair with IC bone grafting.

Methods
With approval of the local ethics committee and after written informed consent was obtained, 36 patients had an interscalene catheter placed preoperatively. Intraoperatively, the surgeon placed a catheter at the IC donor site. At the end of surgery, 30 ml ropivacaine, 0.5% (ropivacaine group), or 30 ml NaCl, 0.9% (placebo group), was administered. Ropivacaine, 0.2%, was started 6 h after the initial block through the interscalene catheter for 48 h (t48) in all patients. At t0, the patient received either 5 ml/h ropivacaine, 0.2% (ropivacaine group), or 5 ml/h NaCl, 0.9% (placebo group), for 48 h through the IC catheter. All patients received an intravenous morphine patient-controlled analgesia device. Pain scores at the shoulder and at the IC donor site were assessed at rest and during motion every 8 h for 48 h and after 3 months. Plasma concentrations of total and unbound ropivacaine, morphine consumption, and patient satisfaction were assessed.

Results
At the IC donor site, pain was significantly lower in the ropivacaine group compared with the placebo group at rest and during motion at any time. Total and unbound plasma concentrations of ropivacaine were below the toxic threshold in both groups. Morphine consumption was significantly lower in the ropivacaine group after 24 and 48 h. Patient satisfaction was significantly higher in the ropivacaine group. At 3 months, pain at the IC during motion was significantly lower in the ropivacaine group.

Conclusions
Continuous application of 0.2% ropivacaine through an IC catheter after Bankart repair with IC bone grafting is an effective method for pain relief for the first 48 h, with few adverse effects and high patient satisfaction. The benefit of this technique is still present after 3 months.
A Randomized Controlled Trial to Evaluate S-Caine Patch™ for Reducing Pain Associated with Vascular Access in Children
Authors: Sethna Navil F. , Verghese Susan T. , Hannallah Raafat S. , Solodiuk Jean C. , Zurakowski David , Berde Charles B. 
Published: January 2005

Background
A randomized, double-blinded trial was performed to evaluate the efficacy and safety of the S-Caine Patch (ZARS, Inc., Salt Lake City, UT), a eutectic mixture of lidocaine and tetracaine, for pain relief during venipuncture in children.

Methods
With institutional review board approval, parental consent, and patient assent, 64 children who were scheduled for medically indicated vascular access at two centers were randomly assigned (2:1) to receive either an S-Caine Patch or a placebo patch for 20 min before venipuncture procedures. The primary outcome measure was the child's rating of pain during venipuncture using the Oucher pain scale. Additional measures of efficacy included the blinded investigator's and an independent observer's four-point categorical scores. Variables were compared between treatments using Mantel-Haenszel summary chi-square tests or Pearson chi-square tests.

Results
The S-Caine Patch produced significantly greater pain relief compared with placebo (median Oucher scores of 0 vs. 60; P < 0.001). Fifty-nine percent of the children in the S-Caine Patch group reported no pain compared with 20% of the children in the placebo patch group. The investigator estimated that 76% of the children in the S-Caine Patch group experienced no pain during venipuncture versus 20% in the placebo patch group (P = 0.001). Independent observer ratings also favored the S-Caine Patchtrade mark (P < 0.001). Mild skin erythema (< 38%) and edema (< 2%) occurred with similar frequencies between the groups.

Conclusion
This study demonstrated that a 20-min application of the S-Caine Patch is effective in lessening pain associated with venipuncture procedures. Adverse events after S-Caine Patch application were mild and transient.
Ketamine Improves the Management of Exaggerated Postoperative Pain Observed in Perioperative Fentanyl-treated Rats
Authors: Richebé Philippe , Rivat Cyril , Laulin Jean-Paul , Maurette Pierre , Simonnet Guy 
Published: January 2005

Background
Although opioids are unsurpassed analgesics, experimental and clinical studies suggest that opioids activate N-methyl-d-aspartate pronociceptive systems leading to pain hypersensitivity and short-term tolerance. Because it is difficult in humans to differentiate pain from hyperalgesia during the postoperative period, the authors performed experimental studies with fentanyl using the rat incisional pain model for evaluating relations between hyperalgesia and short-term tolerance. Because N-methyl-d-aspartate receptor antagonists oppose both pain hypersensitivity and tolerance induced by opioids, the authors examined the capability of ketamine for improving exaggerated postoperative pain management.

Methods
During halothane anesthesia, a hind paw plantar incision was performed in rats receiving four fentanyl subcutaneous injections (100 microg/kg per injection, every 15 min). In some groups, three subcutaneous ketamine injections (10 mg/kg per injection, every 5 h) were performed in saline- or fentanyl-treated rats. One day after surgery, the analgesic effect of morphine (2 mg/kg subcutaneous) was tested. Analgesia, mechanical hyperalgesia, tactile allodynia, and pain score were assessed for several days using the paw pressure vocalization test, the von Frey application test, and the postural disequilibrium test.

Results
Fentanyl induced analgesia but also produced exaggerated postoperative pain as indicated by the enhancement of hyperalgesia, allodynia, and weight-bearing decrease after hind paw plantar incision. Ketamine pretreatment prevented such a fentanyl-induced enhancement of postoperative pain and improved its management by morphine.

Conclusions
By opposing postoperative pain hypersensitivity and subsequent short-term tolerance induced by perioperative opioid use, ketamine not only improves exaggerated postoperative pain management but also provides better postoperative rehabilitation.
Rural‐urban and regional inequality in output, income and consumption in China under economic reforms
Authors: Yao Shujie , Zhang Zongyi , Feng Gengfu 
Published: January 2005

PurposeFast growth in China has led to significant improvement in people's living standards and average income. However, it has also brought about a huge rise in inequality. The purpose of this paper is to analyse regional and rural‐urban inequality using a few income and consumption indicators.Design/methodology/approachData are collected from official statistical sources for all the Chinese provinces over 1978‐1995. Both parametric and non‐parametric methods are used to study the inequality between regions and between the rural and urban sub‐populations. The parametric approach is to test whether per capita incomes among provinces converged over time. The non‐parametric approach is the calculation and decomposition of the Gini coefficient by population sub‐group and income source.FindingsThe results show no evidence of growth convergence in per capita GDP, income and expenditure across provinces, but clear evidence of divergence in per capita rural (and urban) incomes and total expenditures. Three‐quarters of inter‐provincial income inequality are explained by inter‐rural/urban inequality. Inter‐provincial inequality explains more than half of rural inequality and less than half of urban inequality in most years.Originality/valueThis paper uses one of the most complicated datasets for the Chinese regions. It studies inequality using different economic indicators. It considers the different dimensions of inequality in China using two different approaches. The results are important for regional development policies.
A proactive assessment of sick building syndrome
Authors: Thomas‐Mobley Linda , Roper Kathy O. , Oberle Rita 
Published: January 2005

PurposeThis paper describes a new proactive approach for facility managers to assess and manage complaints of “sick buildings”.Design/methodology/approachThe assessment of the “sick building” syndrome problem is multifaceted and should include both objective data such as those collected and analyzed by industrial hygienists, and subjective data such as occupant perception measurements, usually gathered by surveys. The data for this research, both objective and subjective, were provided on a wide variety of office buildings and were analyzed using an artificial neural‐network based model.FindingsCurrent literature on the subject suggests that the cause of poor indoor environments involves many variables interacting in an unlimited number of combinations. Using a blended definition of a narrowly defined “sick building”, a framework for a decision‐making support system for facility managers is provided.Research limitations/implicationsThe data collection was limited to Southeastern US commercial office buildings, but the model has global applicability.Practical implicationsRecommendations are presented to help facility managers better understand the complex nature of the indoor environment based on this research.Originality/valueThis research and data analysis can be tailored to and is applicable to any building type.
Thermal analysis of micro‐channel heat exchangers with two‐phase flow using FEM
Authors: Hegde Pradeep , Seetharamu K.N. , Quadir G.A. , Aswathanarayana P.A. , Abdullah M.Z. , Zainal Z.A. 
Published: January 2005

PurposeTo analyze two‐phase flow in micro‐channel heat exchangers used for high flux micro‐electronics cooling and to obtain performance parameters such as thermal resistance, pressure drop, etc. Both uniform and non‐uniform micro‐channel base heat fluxes are considered.Design/methodology/approachEnergy balance equations are developed for two‐phase flow in micro‐channels and are solved using the finite element method (FEM). A unique ten noded element is used for the channel descritization. The formulation also automatically takes care of single‐phase flow in the micro‐channel.FindingsMicro‐channel wall temperature distribution, thermal resistance and the pressure drop for various uniform micro‐channel base heat fluxes are obtained, both for single‐ and two‐phase flows in the micro‐channel. Results are compared against data available in the literature. The wall temperature distribution for a particular case of non‐uniform base heat flux is also obtained.Research limitations/implicationsThe analysis is done for a single micro‐channel and the effects of multiple or stacked channels are not considered. The analysis needs to be carried out for higher heat fluxes and the validity of the correlation needs to be ascertained through experimentation. Effects of flow mal‐distribution in multiple channels, etc. need to be considered.Practical implicationsThe role of two‐phase flow in micro‐channels for high flux micro‐electronics cooling in reducing the thermal resistance is demonstrated. The formulation is very useful for the thermal design and management of microchannels with both single‐ and two‐phase flows for either uniform or non‐uniform base heat flux.Originality/valueA simple approach to accurately determine the thermal resistance in micro‐channels with two‐phase flow, for both uniform and non‐uniform base heat fluxes is the originality of the paper.
Application of computational fluid dynamics simulation tools for thermal characterization of electronic packages
Authors: Kandasamy Ravi , Subramanyam Suresh 
Published: January 2005

PurposeIn the semiconductor electronics industry, effective heat removal from the integrated circuits (IC) chip, through the electronic package to the environment is crucial to maintain an allowable junction temperature of the IC chip. Thermal performances of such electronic packages are characterized by package thermal resistance called θ‐JA and are widely used in the electronic industry. Improving thermal performance is numerically predicted using computational fluid dynamics (CFD) technique and experimental tests are carried out to verify the numerical predictions. To provide new/additional data and demonstrate CFD technique for thermal characterization of electronic packages with experimental results.Design/methodology/approachThe thermal performance of electronic packages has been studied using a CFD technique. The finite volume method is a technique used for solving a set of partial differential equations in a domain, using control volume based discretization. A detailed thermal model of an electronic package was created using a CFD tool and validated against the experimental data obtained in a natural convection environment, compliant to JEDEC standards. The thermal performance of the package was evaluated for different die sizes and epoxy molding compounds at different power levels. The use of a heat slug was investigated to identify its effect on heat dissipation for the future generations of IC, which are expected to be smaller in size and to dissipate more power. Free convective flow velocities, detailed temperature and heat flow distributions around the package will also be presented.FindingsThe study demonstrates that applying CFD techniques can provide accurate results on estimating thermal characterization of an electronic package. Predicted device junction temperatures as well as the thermal resistance of packages can be predicted with a good accuracy for different ranges of power levels in natural convection. The numerically estimated die junction temperatures have also been found to be accurate and reliable.Research limitations/implicationsThe analysis is limited to an incompressible fluid. The effect of forced convection is not considered.Practical implicationsNew and additional generated data will be helpful in the design and decision making time of the product to choose a low cost and viable thermal performance solution in the cooling of electronic components at low power.Originality/valueThe electronic package involves multi‐material and applying CFD technique is useful to determine the accurate thermal performance and simple and fast to apply for different conditions/material sets. Predictions of junction‐to‐ambient thermal resistance and device junction temperature values are compared against measurements. Excellent correlation was obtained. The results thus obtained compare well with the experimental results, but the computational effort and time required in the analysis is much small as compared.
Taking power seriously in strategic organizational learning
Authors: Voronov Maxim , Yorks Lyle 
Published: January 2005

PurposeThis paper argues that failing to grasp thoroughly the influence of power on the strategy‐making process can severely inhibit the potential of strategy making as a vehicle of organizational learning.Design/methodology/approachFirst the organizational learning perspective on strategic management is sketched and an attempt is made to show how it takes the social aspects of organizing more seriously than earlier perspectives on strategy. It is also noted how this iteration responds or at least has the potential to respond to some of the critiques directed at earlier thinking on strategy from critical management studies (CMS). Then CMS's critique of organizational learning theories is noted and the critiques to re‐conceptualize blockages to learning and knowledge creation are built on.FindingsAn attempt has been made to show that, as in earlier perspectives on strategy, there is still insufficient attention being paid to the role of power in strategic change. This places severe limitations on strategic learning that is possible.Originality/valueConcludes by joining other writers in calling for a less managerialist research in strategy.