bluuebunny/crossref_metadata_2025_split huggingface dataset:
High‐Throughput Screening of pH‐Dependent β‐sheet Self‐Assembling Peptide
Authors: Ye Xin‐Wei , Tian Wen , Han Lu , Li Yi‐Jing , Liu Shan , Lai Wen‐Jia , Liu Yi‐Xuan , Wang Lei , Yang Pei‐Pei , Wang Hao 
Published: January 2024

AbstractpH‐dependent peptide biomaterials hold tremendous potential for cell delivery and tissue engineering. However, identification of responsive self‐assembling sequences with specified secondary structure remains a challenge. In this work, An experimental procedure based on the one‐bead one‐compound (OBOC) combinatorial library is developed to rapidly screen self‐assembling β‐sheet peptides at neutral aqueous solution (pH 7.5) and disassemble at weak acidic condition (pH 6.5). Using the hydrophobic fluorescent molecule thioflavin T (ThT) as a probe, resin beads displaying self‐assembling peptides show fluorescence under pH 7.5 due to the insertion of ThT into the hydrophobic domain, and are further cultured in pH 6.5 solution. The beads with extinguished fluorescence are selected. Three heptapeptides are identified that can self‐assemble into nanofibers or nanoparticles at pH 7.5 and disassemble at pH 6.5. P1 (LVEFRHY) shows a rapid acid response and morphology transformation with pH modulation. Changes in the charges of histidine and hydrophobic phenyl motif of phenylalanine may play important roles in the formation of pH‐responsive β‐sheet nanofiber. This high‐throughput screening method provides an efficient way to identify pH‐dependent β‐sheet self‐assembling peptide and gain insights into structural design of such nanomaterials.
Multifunctional Iron Selenate Sheath of Fe‐Based Anode Achieving High‐Rate Capacity‐Durability Combination of Aqueous Hybrid Energy Storage Devices
Authors: Song Jinyue , Fan Hongguang , Wang Yanpeng , Li Qingping , Zhao Jingwen , Shao Chenchen , Li Tao , Jin Yongcheng , Liu Shuang , Liu Wei 
Published: January 2024

AbstractThe introduction of battery‐type cathode has been commonly considered a preferred approach to boost the energy density of aqueous hybrid energy storage devices (AHESDs) in alkalic systems, but AHESDs with both high energy density and power density are rare due to the great challenge in designing battery‐type anode materials with high rate and durability comparable to capacitive‐type carbon anodes. In this paper, a well‐hydrated iron selenate (FeSeO) sheath is constructed around FeOOH nanorods by a facile electrochemical activation, demonstrating the unique multifunction in fasting charge diffusion, promoting the dissociation of H2O, and inhibiting the irreversible phase transition of FeOOH to inert γ‐Fe2O3, which endow the hydrated sheath coated Fe‐based anodes with an impressive rate capability and superior durability. Thanks to the comprehensive performance of this Fe‐based anode, the assembled AHESD delivered a high energy density of 117 Wh kg−1 with the extraordinary durability of almost 100% capacity retention after 40 000 cycles. Even at an ultrahigh power density of 27 000 W kg−1, an impressive energy density of 65 Wh kg−1 can be achieved, which rivals previously reported energy‐storage devices.
Spray Pyrolysis Regulated FeCo Alloy Anchoring on Nitrogen–Doped Carbon Hollow Spheres Boost the Performance of Zinc–Air Batteries
Authors: Huang Hongrui , Liang Qianqian , Guo Huajun , Wang Zhixing , Yan Guochun , Wu Feixiang , Wang Jiexi 
Published: January 2024

AbstractLow‐cost and high‐efficiency non‐precious metal‐based oxygen reduction reaction (ORR)/oxygen evolution reaction (OER) bifunctional catalysts are the key to promoting the commercial application of metal–air batteries. Herein, a highly efficient catalyst of Fe0.18Co0.82 alloy anchoring on the nitrogen‐doped porous carbon hollow sphere (FexCo1‐x/N‐C) is intelligently designed by spray pyrolysis (SP). The zinc in the SP‐derived metal oxides and metal‐organic framework volatilize at high temperature to construct a hierarchical porous structure with abundant defects and fully exposes the FeCo nanoparticles which uniformly anchor on the carbon substrate. In this structure, the coexistence of Fe0.18Co0.82 alloy and binary metal active sites (Fe‐Nx/Co‐Nx) guarantees the Fe0.2Co0.8/N‐C catalyst exhibiting an excellent half‐wave potential (E1/2 ═ 0.84 V) superior to 20% Pt/C for ORR and a suppressed overpotential (280 mV) than RuO2 for OER. Assembled rechargeable Zn–air battery (RZAB) demonstrates a promising specific capacity of 807.02 mAh g−1, peak power density of 159.08 mW cm−2 and durability without electrolyte circulation (550 h). This work proposes the design concept of utilizing an oxide core to in situ consume the porous carbon shell for anchoring metal active sites and construct defects, which benefits from spray pyrolysis in achieving precise control of the alloy structure and mass preparation.
LiOH Decomposition by NiO/ZrO2 in Li‐Air Battery: Chemical Imaging with Operando Synchrotron Diffraction and Correlative Neutron/X‐Ray Computed‐Tomography Analysis
Authors: Anchieta Chayene Gonçalves , Francisco Bruno A.B. , Júlio Julia P. O. , Trtik Pavel , Bonnin Anne , Doubek Gustavo , Sanchez Dario Ferreira 
Published: January 2024

AbstractLi‐air batteries attract significant attention due to their highest theoretical energy density among all existing energy storage technologies. Currently, challenges related to extending lifetime and long‐term stability limit their practical application. To overcome these issues and enhance the total capacity of Li‐air batteries, this study introduces an innovative approach with NiO/ZrO2 catalysts. Operando advanced chemical imaging with micrometer spatial resolution unveils that NiO/ZrO2 catalysts substantially change the kinetics of crystalline lithium hydroxide (LiOH) formation and facilitate its rapid decomposition with heterogeneous distribution. Moreover, ex situ combined neutron and X‐ray computed tomography (CT) analysis, provide evidence of distinct lithium phases homogeneously distributed in the presence of NiO/ZrO2. These findings underscore the material's superior physico‐chemical and electronic properties, with more efficient oxygen diffusion and indications of lower obstruction to its active sites, avoiding clogging in the active electrode, a common cause of capacity loss. Electrochemical tests conducted at high current density demonstrated a significant kinetic enhancement of the oxygen reduction and evolution reactions, resulting in improved charge and discharge processes with low overpotential. This pioneering approach using NiO/ZrO2 catalysts represents a step toward on developing the full potential of Li‐air batteries as high‐energy‐density energy storage systems.
What are delusions? Examining the typology problem
Authors: López‐Silva Pablo , de Prado‐Gordillo Miguel Núñez , Fernández‐Castro Victor 
Published: January 2024

AbstractDelusions are a heterogenous transdiagnostic phenomenon with a higher prevalence in schizophrenia. One of the most fundamental debates surrounding the philosophical understanding of delusions concerns the question about the type of mental state in which reports that we label as delusional are grounded, namely, the typology problem. The formulation of potential answers for this problem seems to have important repercussions for experimental research in clinical psychiatry and the development of psychotherapeutic tools for the treatment of delusions in clinical psychology. Problematically, such alternatives are scattered in the literature, making it difficult to follow the current development and state of the target discussion. This paper offers an updated critical examination of the alternatives to the typology problem currently available in the literature. After clarifying the two main philosophical views underlying the dominant formulation of the debate (interpretivism and functionalism), we follow the usual distinction between doxastic (the idea that delusions are a type of belief) and anti‐doxastic views. We then introduce two new sub‐distinctions; on the doxastic camp, we distinguish between revisionist and non‐revisionist proposals; on the anti‐doxastic camp, we distinguish between commonsensical and non‐commonsensical anti‐doxasticisms. After analyzing the main claims of each view, we conclude with some of the most fundamental challenges that remain open within the discussion.This article is categorized under:
Philosophy > Foundations of Cognitive Science
Philosophy > Consciousness
Philosophy > Psychological Capacities
Neuroscience > Cognition
TLQP-21 facilitates diabetic wound healing by inducing angiogenesis through alleviating high glucose-induced injuries on endothelial progenitor cells
Authors: Fang Yaqi , Zhu Yuexia , Zhang Minxia , Ying Hua , Xing Yubo 
Published: January 2024

AbstractDiabetes mellitus (DM) is a metabolic disease with multiple complications, including diabetic cutaneous wounds, which lacks effective treating strategies and severely influences the patients’ life. Endothelial progenitor cells (EPCs) are reported to participate in maintaining the normal function of blood vessels, which plays a critical role in diabetic wound healing. TLQP-21 is a VGF-derived peptide with promising therapeutic functions on DM. Herein, the protective effects of TLQP-21 on diabetic cutaneous wound and the underlying mechanism will be investigated. Cutaneous wound model was established in T2DM mice, followed by administering 120 nmol/kg and 240 nmol/kg TLQP-21 once a day for 12 days. Decreased wound closure, reduced number of capillaries and EPCs, declined tube formation function of EPCs, and inactivated PI3K/AKT/eNOS signaling in EPCs were observed in T2DM mice, which were sharply alleviated by TLQP-21. Normal EPCs were extracted from mice and stimulated by high glucose (HG), followed by incubated with TLQP-21 in the presence or absence of LY294002, an inhibitor of PI3K. The declined cell viability, increased apoptotic rate, reduced number of migrated cells, declined migration distance, repressed tube formation function, and inactivated PI3K/AKT/eNOS signaling observed in HG-treated EPCs were markedly reversed by TLQP-21, which were dramatically abolished by the co-culture of LY294002. Collectively, TLQP-21 facilitated diabetic wound healing by inducing angiogenesis through alleviating HG-induced injuries on EPCs.
Distinct alterations of gut microbiota between viral- and non-viral-related hepatocellular carcinoma
Authors: Jinato Thananya , Anuntakarun Songtham , Satthawiwat Nantawat , Chuaypen Natthaya , Tangkijvanich Pisit 
Published: January 2024

Abstract
Altered gut microbiota has been connected to hepatocellular carcinoma (HCC) occurrence and advancement. This study was conducted to identify a gut microbiota signature in differentiating between viral-related HCC (Viral-HCC) and non-hepatitis B-, non-hepatitis C-related HCC (NBNC-HCC). Fecal specimens were obtained from 16 healthy controls, 33 patients with viral-HCC (17 and 16 cases with hepatitis B virus (HBV) and hepatitis C virus (HCV) infection, respectively), and 18 patients with NBNC-HCC. Compositions of fecal microbiota were assessed by 16S rRNA sequencing. Bioinformatic analysis was performed by the DADA2 pipeline in the R program. Significantly different genera from the top 50 relative abundance were used to classify between subgroups of HCC by the Random Forest algorithm. Our data demonstrated that the HCC group had a significantly decreased alpha-diversity and changed microbial composition in comparison with healthy controls. Within the top 50 relative abundance, there were 11 genera including Faecalibacterium, Agathobacter, and Coprococcus that were significantly enhanced in Viral-HCC, while 5 genera such as Bacteroides, Streptococcus, Ruminococcus gnavus group, Parabacteroides, and Erysipelatoclostridium were enhanced in NBNC-HCC. Compared to Viral-HCC, the NBNC-HCC subgroup significantly reduced various short-chain fatty acid-producing bacteria, as well as declined fecal butyrate but elevated plasma surrogate markers of microbial translocation. Based on the machine learning algorithm, a high diagnostic accuracy to classify HCC subgroups was achieved with an area under the receiver-operating characteristic (ROC) curve (AUC) of 0.94. Collectively, these data revealed that gut dysbiosis was distinct according to etiological factors of HCC, which might play an essential role in hepatocarcinogenesis. These findings underscore the possible use of a gut microbiota signature for the diagnosis and therapeutic approaches regarding different subgroups of HCC.

Key points
• Gut dysbiosis is connected to hepatocarcinogenesis and can be used as a novel biomarker.
• Gut microbiota composition is significantly altered in different etiological factors of HCC.
• Microbiota-based signature can accurately distinguish between Viral-HCC and NBNC-HCC.
Deducing photosymbiosis in extinct heliolitid corals
Authors: Król J. J. , Berkowski B. , Denayer J. , Zapalski M. K. 
Published: January 2024

AbstractThe matter of photosymbiosis in Paleozoic corals remains unresolved as it is not possible to directly check for the presence of algal symbionts in fossil corals. However, present-day photosymbiotic corals are characterised by a number of features that can be evaluated in fossil corals as well, such as large, highly integrated colonies, growth banding, and platy growth forms in mesophotic conditions. The present study aims to evaluate these features in heliolitid corals. Heliolitids were relatively highly integrated, compared to other Paleozoic corals and could produce large colonies, over 1 m in diameter. In this study, heliolitid corals from different outcrops from the Silurian (~ 444 to 419 ma) of Gotland (Sweden) were analysed, and additional Devonian (~ 419 to 359 ma) specimens from Belgium, Poland and Morocco, featuring cyclic growth banding, were also included. Overall, over 60% of studied specimens from Lower Visby Formation in Ireviken and over 80% from Eke Formation in Lau Käldu are platy or tabular. Those outcrops represent environments that were mesophotic. Specimens from the shallower Upper Visby Formation in Ygne are dominated by branching forms instead. The apparent light-related skeletal plasticity, high colony integration, growth banding, and the absence of heliolitids in deep water environments implies that some of these corals were most likely photosymbiotic.
CSF p-tau205: a biomarker of tau pathology in Alzheimer’s disease
Authors: Lantero-Rodriguez Juan , Montoliu-Gaya Laia , Benedet Andrea L. , Vrillon Agathe , Dumurgier Julien , Cognat Emmanuel , Brum Wagner S. , Rahmouni Nesrine , Stevenson Jenna , Servaes Stijn , Therriault Joseph , Becker Bruno , Brinkmalm Gunnar , Snellman Anniina , Huber Hanna , Kvartsberg Hlin , Ashton Nicholas J. , Zetterberg Henrik , Paquet Claire , Rosa-Neto Pedro , Blennow Kaj 
Published: January 2024

AbstractPost-mortem staging of Alzheimer’s disease (AD) neurofibrillary pathology is commonly performed by immunohistochemistry using AT8 antibody for phosphorylated tau (p-tau) at positions 202/205. Thus, quantification of p-tau205 and p-tau202 in cerebrospinal fluid (CSF) should be more reflective of neurofibrillary tangles in AD than other p-tau epitopes. We developed two novel Simoa immunoassays for CSF p-tau205 and p-tau202 and measured these phosphorylations in three independent cohorts encompassing the AD continuum, non-AD cases and cognitively unimpaired participants: a discovery cohort (n = 47), an unselected clinical cohort (n = 212) and a research cohort well-characterized by fluid and imaging biomarkers (n = 262). CSF p-tau205 increased progressively across the AD continuum, while CSF p-tau202 was increased only in AD and amyloid (Aβ) and tau pathology positive (A+T+) cases (P < 0.01). In A+ cases, CSF p-tau205 and p-tau202 showed stronger associations with tau-PET (rSp205 = 0.67, rSp202 = 0.45) than Aβ-PET (rSp205 = 0.40, rSp202 = 0.09). CSF p-tau205 increased gradually across tau-PET Braak stages (P < 0.01), whereas p-tau202 only increased in Braak V–VI (P < 0.0001). Both showed stronger regional associations with tau-PET than with Aβ-PET, and CSF p-tau205 was significantly associated with Braak V–VI tau-PET regions. When assessing the contribution of Aβ and tau pathologies (indexed by PET) to CSF p-tau205 and p-tau202 variance, tau pathology was found to be the most prominent contributor in both cases (CSF p-tau205: R2 = 69.7%; CSF p-tau202: R2 = 85.6%) Both biomarkers associated with brain atrophy measurements globally (rSp205 = − 0.36, rSp202 = − 0.33) and regionally, and correlated with cognition (rSp205 = − 0.38/− 0.40, rSp202 = − 0.20/− 0.29). In conclusion, we report the first high-throughput CSF p-tau205 immunoassay for the in vivo quantification of tau pathology in AD, and a potentially cost-effective alternative to tau-PET in clinical settings and clinical trials.
Improved prognostic stratification of patients with isocitrate dehydrogenase-mutant astrocytoma
Authors: Weller Michael , Felsberg Jörg , Hentschel Bettina , Gramatzki Dorothee , Kubon Nadezhda , Wolter Marietta , Reusche Matthias , Roth Patrick , Krex Dietmar , Herrlinger Ulrich , Westphal Manfred , Tonn Joerg C. , Regli Luca , Maurage Claude-Alain , von Deimling Andreas , Pietsch Torsten , Le Rhun Emilie , Reifenberger Guido 
Published: January 2024

AbstractPrognostic factors and standards of care for astrocytoma, isocitrate dehydrogenase (IDH)-mutant, CNS WHO grade 4, remain poorly defined. Here we sought to explore disease characteristics, prognostic markers, and outcome in patients with this newly defined tumor type. We determined molecular biomarkers and assembled clinical and outcome data in patients with IDH-mutant astrocytomas confirmed by central pathology review. Patients were identified in the German Glioma Network cohort study; additional cohorts of patients with CNS WHO grade 4 tumors were identified retrospectively at two sites. In total, 258 patients with IDH-mutant astrocytomas (114 CNS WHO grade 2, 73 CNS WHO grade 3, 71 CNS WHO grade 4) were studied. The median age at diagnosis was similar for all grades. Karnofsky performance status at diagnosis inversely correlated with CNS WHO grade (p < 0.001). Despite more intensive treatment upfront with higher grade, CNS WHO grade was strongly prognostic: median overall survival was not reached for grade 2 (median follow-up 10.4 years), 8.1 years (95% CI 5.4–10.8) for grade 3, and 4.7 years (95% CI 3.4–6.0) for grade 4. Among patients with CNS WHO grade 4 astrocytoma, median overall survival was 5.5 years (95% CI 4.3–6.7) without (n = 58) versus 1.8 years (95% CI 0–4.1) with (n = 12) homozygous CDKN2A deletion. Lower levels of global DNA methylation as detected by LINE-1 methylation analysis were strongly associated with CNS WHO grade 4 (p < 0.001) and poor outcome. MGMT promoter methylation status was not prognostic for overall survival. Histomolecular stratification based on CNS WHO grade, LINE-1 methylation level, and CDKN2A status revealed four subgroups of patients with significantly different outcomes. In conclusion, CNS WHO grade, global DNA methylation status, and CDKN2A homozygous deletion are prognostic in patients with IDH-mutant astrocytoma. Combination of these parameters allows for improved prediction of outcome. These data aid in designing upcoming trials using IDH inhibitors.
Predictors in the treatment of malignant central airway obstruction with silicone stents
Authors: Bøgh Mads , Gade Søren , Larsen Dalia Gustaityté , Schytte Sten , Pedersen Ulrik , Kjærgaard Thomas 
Published: January 2024

Abstract
Purpose
To examine the role of the silicone stent in palliation of malignant central airway obstruction and identify potential preprocedural predictors for postprocedural outcome.

Methods
Patients treated with endoscopic insertion of tracheobronchial silicone stents for malignant central airway obstruction at Aarhus University Hospital from 2012 to 2022 were identified from electronic medical records. Statistical analyses were carried out to identify factors affecting Days Alive and Out of Hospital, complications and overall survival.

Results
81 patients underwent a total of 90 tracheobronchial stent insertions. Days Alive and Out of Hospital (DAOH) for the first 30 days were affected negatively by urgent intervention, p < 0.001, preprocedural non-invasive respiratory support, p < 0.001, and preprocedural intubation, p = 0.02. Post-procedural oncological treatment was associated with a significant improved DAOH, p = 0.04. Symptomatology and lesion characteristics were not significantly associated with any impact on DAOH. Overall survival was poor (mean survival was 158 days), and only significantly affected by severe degree of dyspnea, p = 0.02, and postprocedural oncological treatment, p < 0.001. Complication where registered in 25.6% of cases within the first 30 days was observed. Procedure-related mortality was 3.7%. Based on chart annotations by an ENT-surgeon, 95% of the patients experienced relief of symptoms following stent insertion.

Conclusions
Palliative tracheobronchial airway stenting with silicone stents is found to have a beneficial impact, more research is required for identification of predictors for postprocedural outcome based on preprocedural classifications.
How personality functioning relates to psychological distress and behavioral attitudes during the Covid-19 pandemic
Authors: Kampe Leonie , Hörz-Sagstetter Susanne , Bohn Johannes , Remmers Carina 
Published: January 2024

Abstract
Functional aspects of personality are crucial for experiencing and handling emotional distress. With the outbreak of the Covid-19 virus and the subsequent installation of mitigation rules of social distancing, severe psycho-social challenges were posed upon people. Research has shown that individuals react differently to these challenges. This study aimed to investigate the role of dimensional aspects of personality during the Covid-19 pandemic. Specifically, we examined how personality functioning, defense mechanisms, and narcissism were related to psychological distress and cognitive and behavioral attitudes towards the rules of social distancing. In a non-clinical sample (N = 254), Level of Personality Functioning Scale, Inventory of Personality Organization, Defense Style Questionnaire, Pathological Narcissism Inventory, and three single questions regarding emotional distress and behavioral attitudes towards the pandemic were used. Structural equation models with reference and residual factors were calculated. Impairments in personality functioning and vulnerable narcissism showed significant positive relationships, adaptive defense mechanisms significant negative relationships with psychological distress during the pandemic. Residual factors for aggression and low moral values showed distinct negative relationships with psychological distress related to social distancing. Among individuals who chose to ignore the rules of social distancing, greater impairment in personality organization was found. Personality functioning may elucidate individual differences in psychological distress and compliance with the mitigation rules during the pandemic. Limitations of measures are carefully considered in all interpretations.