bluuebunny/crossref_metadata_2025_split huggingface dataset:
Primary central nervous system marginal zone lymphoma
Authors: Flospergher Elena , Marino Fabrizio , Calimeri Teresa , Cangi Maria Giulia , Ferreri Andrés José María , Ponzoni Maurilio , Bongiovanni Lucia 
Published: December 2023

SummaryMarginal zone lymphoma (MZL) is the most common indolent lymphoma primarily arising in the central nervous system (CNS). To date, 207 cases of primary CNS MZL (PCNSMZL) were published, mostly as single case reports or small case series. It most commonly presents as extra‐axial dural‐based masses, more frequently in middle‐aged women, displaying an insidious onset, with a long history of symptoms preceding the diagnosis. PCNSMZL can be radiographically mistaken for meningioma. PCNSMZL consists of CD20+, CD3− small B lymphocytes with varying degrees of plasmacytic differentiation and low proliferation index. Trisomy 3, but not MALT1 or IgH translocation, is a common genetic abnormality. Other recurrent genetic abnormalities involve TNFAIP3 and NOTCH2. Ethiopathogenesis was poorly investigated. Due to its rarity, standard of care remains to be defined; it exhibits an excellent prognosis after varied treatments, such as surgery, radiotherapy, chemotherapy or their combinations. Nevertheless, each treatment should be considered after an accurate analysis of overtreatment risk. Short follow‐up is a major limitation in reported PCNSMZL cases, which restrains our knowledge on long‐term results and iatrogenic sequels. This review was focussed on presentation, differential diagnoses, pathological findings, treatment options and clinical outcomes of PCNSMZL; recommendations for best clinical practice are provided.
Thought and language: Effects of group‐mindedness on young children's interpretation of exclusive we
Authors: Vasil Jared , Price Dayna , Tomasello Michael 
Published: December 2023

AbstractThe current study investigated whether age‐related changes in the conceptualization of social groups influences interpretation of the pronoun we. Sixty‐four 2‐ and 4‐year‐olds (N = 29 female, 50 White‐identifying) viewed scenarios in which it was ambiguous how many puppets performed an activity together. When asked who performed the activity, a speaker puppet responded, “We did!” In one condition, the speaker was near one and distant from another puppet, implying a dyadic interpretation of we. In another condition, the speaker was distant from both, thus pulling for a group interpretation. In the former condition, 2‐ and 4‐year‐olds favored the dyadic interpretation. In the latter condition, only 4‐year‐olds favored the group interpretation. Age‐related conceptual development “expands” the set of conceivable plural person referents.
Rethinking value in public management
Authors: Jensen Tobias Berggren , Waldorff Susanne Boch , Kornberger Martin 
Published: December 2023

AbstractWith the ascent of the concept of public value, the theory and practice of administration have shifted from a focus on management, effectiveness and efficiency (as espoused in New Public Management) towards an agenda of public value creation. This has resulted in a large, heterogenous number of scholarly publications on public value. In this paper, we review this important body of work from the period 1994 to 2019, discuss it critically and propose a few avenues for future research – especially in terms of conceptualizing public value. We do so by using a mixed‐methods approach, incorporating semantic‐network analysis, which allows a comprehensive quantitative and qualitative analysis of the field of public value. In this article we show in great detail how the literature on public value has evolved and is configured, categorize how value is defined and measured within the literature, introduce a novel mixed‐methods approach for literature reviews, and provide three conceptual contributions including (1) digitalization in public value theory can expand our understanding of citizens, (2) public value is more than just public, and (3) visualizing public value through controversy maps. Finally, we provide suggestions for further research.
“Do as we say and you'll be successful”: Mundane power in corporate entrepreneurship
Authors: Skade Lorenzo , Wenzel Matthias , Koch Jochen 
Published: December 2023

AbstractCorporate entrepreneurship is infused with power. Prior research has begun to shed light on the role of power in innovation contexts. Yet, we know much less about the day‐to‐day enactment of mundane power in corporate entrepreneurship, which, despite its partial subtlety, is no less consequential regarding decisions on pursuing or abandoning innovative ideas. This paper extends the literature on corporate entrepreneurship and power by exploring the discursive practices through which managers and employees of a corporate accelerator disciplined venture founders in the pursuit of innovative ideas. Based on a Foucauldian discourse analysis of ethnographic data, we show how a clash of entrepreneurship discourses invokes the day‐to‐day performance of three discursive practices—observing, exercising, and punishing—through which the accelerator's staff ensured that venture founders would adopt a dominant entrepreneurship discourse, with important implications for decisions on pursuing innovative ideas or not. These findings deepen our understanding of enacting mundane power in corporate entrepreneurship as well as the enablers and outcomes of such power enactment. We also outline the practical implications for emerging corporate innovation settings such as accelerators.
Role of Eruca sativa L. seeds in boosting the reproductive performance of male Japanese quails (Coturnix c. japonica)
Authors: Waly Hanan S. A. , Abdelfattah Mostafa Galal , Abou Khalil Nasser S. , Ragab Sohair M. M. 
Published: December 2023

AbstractHerein we attempt to shed light on the potential improving effect of Eruca sativa seeds (ESS) on the reproductive aspects of male Japanese quails. To accomplish this objective, two groups of quails were supplemented with ESS powder at doses of 5 and 10 g/kg feed from 7 days to 140 days of age, in addition to the control group, which did not receive treatment. Forty males were reared singly in cages to evaluate sperm characters and 32 males were raised with 64 females to evaluate fertility and sperm penetrability. Sixty‐six phytochemical compounds were found according to gas chromatography–mass spectrometry analysis of ESS. The most plentiful ones are 13‐docosenoic acid methyl ester, 9‐octadecenoic acid methyl ester, and linoleic acid methyl ester. Both 5 g/kg and 10 g/kg doses of ESS showed similar effectiveness in enhancing various reproductive parameters, including gonadal index, sperm characteristics, fertility, libido, and cloacal gland attributes. However, some aspects like sperm concentration and testosterone levels exhibited a dose‐dependent response. There is no significant change in mortality rate of supplemented groups compared to the control one. ESS also caused a reduction in feed intake and an enhancement in feed conversion ratio without affecting final body weight and body weight gain. This suggests potential nutritional benefits beyond reproductive health. The low‐dose‐fed group showed a significant reduction in total cholesterol and malondialdehyde compared to the high‐dose‐fed and unfed groups. The higher dose notably increased total antioxidant capacity compared to the lower dose and control group. Despite the positive effects on male reproductive parameters, there wasn't a significant impact on hatchability percentage, indicating that while male fertility improved, it might not have directly affected the viability of the eggs. Overall, the study suggests that ESS could be a safe and promising addition to the diet of male Japanese quails to enhance their reproductive capabilities without adverse effects. The findings could have implications for poultry farming by potentially improving breeding efficiency and health outcomes in quails.
Demographic history shapes North American gray wolf genomic diversity and informs species' conservation
Authors: vonHoldt Bridgett M. , Stahler Daniel R. , Brzeski Kristin E. , Musiani Marco , Peterson Rolf , Phillips Michael , Stephenson John , Laudon Kent , Meredith Erin , Vucetich John A. , Leonard Jennifer A. , Wayne Robert K. 
Published: December 2023

AbstractEffective population size estimates are critical information needed for evolutionary predictions and conservation decisions. This is particularly true for species with social factors that restrict access to breeding or experience repeated fluctuations in population size across generations. We investigated the genomic estimates of effective population size along with diversity, subdivision, and inbreeding from 162,109 minimally filtered and 81,595 statistically neutral and unlinked SNPs genotyped in 437 grey wolf samples from North America collected between 1986 and 2021. We found genetic structure across North America, represented by three distinct demographic histories of western, central, and eastern regions of the continent. Further, grey wolves in the northern Rocky Mountains have lower genomic diversity than wolves of the western Great Lakes and have declined over time. Effective population size estimates revealed the historical signatures of continental efforts of predator extermination, despite a quarter century of recovery efforts. We are the first to provide molecular estimates of effective population size across distinct grey wolf populations in North America, which ranged between Ne ~ 275 and 3050 since early 1980s. We provide data that inform managers regarding the status and importance of effective population size estimates for grey wolf conservation, which are on average 5.2–9.3% of census estimates for this species. We show that while grey wolves fall above minimum effective population sizes needed to avoid extinction due to inbreeding depression in the short term, they are below sizes predicted to be necessary to avoid long‐term risk of extinction.
Phase‐locked breathing does not affect episodic visual recognition memory but does shape its corresponding ERPs
Authors: Schaefer Martin , Hrysanidis Caitlin , Lundström Johan N. , Arshamian Artin 
Published: December 2023

AbstractRecent studies have indicated that breathing shapes the underlying oscillatory brain activity critical for episodic memory, potentially impacting memory performance. However, the literature has presented conflicting results, with some studies suggesting that nasal inhalation enhances visual memory performance, while others have failed to observe any significant effects. Furthermore, the specific influence of breathing route (nasal vs. mouth) and the precise phase of the respiratory cycle during which stimuli are presented have remained elusive. To address this, we employed a visual recognition memory (VRM) and electroencephalography paradigm in which stimuli presentation was phase‐locked to either inhalation or exhalation onset, using a within‐subject design where participants performed the memory task while engaging in separate sessions of nose and mouth breathing. We show that neither breathing route nor breathing phase has a significant impact on VRM performance as measured by d‐prime, with the data supporting the null hypothesis. However, we did find an effect of breathing phase on response bias, with participants adopting a more conservative decision criterion during exhalation. Moreover, we found that breathing phase during memory encoding shaped the late parietal effect (LPE) amplitude, while the Frontal Negative Component (FN400) and LPE during recognition were less impacted. While our study demonstrates that breathing does not shape VRM performance, it shows that it influences brain activity, reinforcing the importance of further research to elucidate the extent of respiratory influence on perception, cognition, and behavior.
In Patients With Chronic Pain Conditions, Does Dry Needling Reduce Pain?
Authors: Kleinhesselink Paden , Tierney Ryan , Mansell Jamie , Russ Anne 
Published: December 2023

Dry needling’s primary goal is to alleviate pain by inserting solid filament needles into muscles, tendons, and ligaments to provide a stimulus that inhibits nerve endings to decrease pain. This critically appraised topic investigates the effects dry needling has on patients with various chronic pain conditions and its ability to relieve pain. Articles were selected if patients had a chronic pain condition lasting at least 3 months, pain was reported using the Visual Analog Scale, and were randomized control trials or prospective studies. All selected studies for this critically appraised topic showed significant improvement in chronic pain. With these improvements, dry needling has been shown to be an effective treatment in chronic pain conditions.
Reliability and Validity of the International Physical Activity Questionnaire Adapted to Include Adults With Physical Disability
Authors: Clina Julianne G. , Sayer R. Drew , Friedman James E. , Chui Tsz Kiu , Mehta Tapan , Rimmer James H. , Hill James O. 
Published: December 2023

Background: People with physical disabilities (PWD) participate in less physical activity than people without physical disabilities (PWoD), which increases the risk for several negative health consequences. Comparing physical activity between PWD and PWoD remains a challenge since no reliable and valid survey exists to measure physical activity in both populations. The International Physical Activity Questionnaire (IPAQ) was adapted to be inclusive of PWD using a recently developed survey adaption framework; however, the adapted IPAQ has not been assessed for reliability and validity. The objective of this study was to assess the reliability and validity of the adapted IPAQ. Methods: To assess test–retest reliability, the adapted IPAQ was completed twice within a 72-hour period by 172 individuals (PWD: n = 102, PWoD: n = 70) and compared using intraclass correlation coefficients. Using Spearman rho, convergent validity and construct validity were assessed in 62 individuals by comparing the adapted IPAQ against the original instrument and activity monitor measured step count, respectively. Results: The adapted IPAQ demonstrated moderate test–retest reliability, with intraclass correlation coefficients of total scores for the total sample of .690 (95% confidence interval [CI] .581–.770) and among subgroup analysis (PWD, .640, 95% CI, .457–.761; PWoD, .758, 95% CI, .610–.850). Correlation coefficients were also good for the assessment of convergent validity of total score (.727; 95% CI, .579–.829; P < .001). Construct validity assessment yielded moderate coefficient (.406; 95% CI, .166–.596; P = .001). Conclusions: The adapted IPAQ demonstrated acceptable reliability and validity and is appropriate for use in PWD and PWoD.
TrhA, a bacterial progestin and adiponectin receptor homolog, couples membrane energetics homeostasis and unsaturated fatty acid metabolism
Authors: Melchionna Maddison , Ganusova Elena E. , Harmon Neyland , Alexandre Gladys 
Published: December 2023

ABSTRACT

Members of the widely conserved progestin and adipoQ receptor (PAQR) family function to maintain membrane homeostasis: membrane fluidity and fatty acid composition in eukaryotes and membrane energetics and fatty acid composition in bacteria. All PAQRs consist of a core seven transmembrane domain structure and five conserved amino acids (three histidines, one serine, and one aspartic acid) predicted to form a hydrolase-like catalytic site. PAQR homologs in Bacteria (called TrhA, for transmembrane homeostasis protein A) maintain homeostasis of membrane charge gradients, like the membrane potential and proton gradient that comprise the proton motive force, but their molecular mechanisms are not yet understood. Here, we show that TrhA in
Escherichia coli
has a periplasmic C-terminus, which places the five conserved residues shared by all PAQRs at the cytoplasmic interface of the membrane. Here, we characterize several conserved residues predicted to form an active site by site-directed mutagenesis. We also identify a specific role for TrhA in modulating unsaturated fatty acid biosynthesis with conserved residues required to either promote or reduce the abundance of unsaturated fatty acids. We also identify distinct roles for the conserved residues in supporting TrhA’s role in maintaining membrane energetics homeostasis that suggest that both functions are intertwined and probably partly dependent on one another. An analysis of domain architecture of TrhA-like domains in Bacteria further supports a function of TrhA linking membrane energetics homeostasis with biosynthesis of unsaturated fatty acid in the membrane.

IMPORTANCE
Progestin and adipoQ receptor (PAQR) family proteins are evolutionary conserved regulators of membrane homeostasis and have been best characterized in eukaryotes. Bacterial PAQR homologs, named TrhA (transmembrane homeostasis protein A), regulate membrane energetics homeostasis through an unknown mechanism. Here, we present evidence linking TrhA to both membrane energetics homeostasis and unsaturated fatty acid biosynthesis. Analysis of domain architecture together with experimental evidence suggests a model where TrhA activity on unsaturated fatty acid biosynthesis is regulated by changes in membrane energetics to dynamically adjust membrane homeostasis.
Complete genome sequence of
Moraxella
sp. strain DOX410, a bacterium potentially degrading 1,4-dioxane isolated from river sediment
Authors: Ryu Byung-Gon , Kang Hye Kyeong , Lee Mi-Hwa , Chun Byung Hee 
Published: December 2023

ABSTRACT

Moraxella
sp. strain DOX410 was isolated from a systematic enrichment culture to investigate strains with 1,4-dioxane degradation potential. The genome of strain DOX410 consists of five complete contigs and contained genes related to degradation of the aromatic ring structure of 1,4-dioxane.
Waste not, want not: revisiting the analysis that called into question the practice of rarefaction
Authors: Schloss Patrick D. 
Published: December 2023

ABSTRACT
In 2014, McMurdie and Holmes published the provocatively titled “Waste not, want not: why rarefying microbiome data is inadmissible.” The claims of their study have significantly altered how microbiome researchers control for the unavoidable uneven sequencing depths that are inherent in modern 16S rRNA gene sequencing. Confusion over the distinction between the definitions of rarefying and rarefaction continues to cloud the interpretation of their results. More importantly, the authors made a variety of problematic choices when designing and analyzing their simulations. I identified 11 factors that could have compromised the results of the original study. I reproduced the original simulation results and assessed the impact of those factors on the underlying conclusion that rarefying data is inadmissible. Throughout, the design of the original study made choices that caused rarefying and rarefaction to appear to perform worse than they truly did. Most important were the approaches used to assess ecological distances, the removal of samples with low sequencing depth, and not accounting for conditions where sequencing effort is confounded with treatment group. Although the original study criticized rarefying for the arbitrary removal of valid data, repeatedly rarefying data many times (i.e., rarefaction) incorporates all the data. In contrast, it is the removal of rare taxa that would appear to remove valid data. Overall, I show that rarefaction is the most robust approach to control for uneven sequencing effort when considered across a variety of alpha and beta diversity metrics.

IMPORTANCE
Over the past 10 years, the best method for normalizing the sequencing depth of samples characterized by 16S rRNA gene sequencing has been contentious. An often cited article by McMurdie and Holmes forcefully argued that rarefying the number of sequence counts was “inadmissible” and should not be employed. However, I identified a number of problems with the design of their simulations and analysis that compromised their results. In fact, when I reproduced and expanded upon their analysis, it was clear that rarefaction was actually the most robust approach for controlling for uneven sequencing effort across samples. Rarefaction limits the rate of falsely detecting and rejecting differences between treatment groups. Far from being “inadmissible”, rarefaction is a valuable tool for analyzing microbiome sequence data.
Responses of microbial community dynamics, co-occurrences, functional shifts, and natural fermentation profiles of
Elymus nutans
silage to altitudinal gradients
Authors: Su Rina , Li Fuhou , Liang Ying , Sheoran Neha , Bai Jie , Hao Lizhuang , Ke Wencan , Hu Chen , Jia Mengya , Usman Samaila , Chen Mengyan , Guo Xusheng 
Published: December 2023

ABSTRACT

This study investigated the microbial diversity, functionality, and fermentation quality of
Elymus nutans
(
E. nutans
) silage across different altitudinal gradients. Forage samples were gathered from three areas in Qinghai province, China, namely, Huangyuan (HY, altitude of 2,613 m); Xinghai (XH, altitude of 3,612 m), and Chenduo (CD, altitude of 4,589 m) counties. Chopped
E. nutans
were ensiled at local room temperature and sampled after 7, 14, 30, and 60 days of ensiling. The results exhibited that the bacterial diversity and numbers of the lactic acid bacteria (LAB) and yeast in
E. nutans
forage decreased, while the water-soluble carbohydrates and crude protein increased along the altitudinal gradients. This led to clear differences in fermentation qualities and bacterial community dynamics. The silage from CD with high altitude showed a higher fermentation quality, more stable bacterial network structure, and lower abundance of amino acid metabolism than ensiled forages collected from the other regions (
P
< 0.05). Meanwhile, the LAB including
Lacticaseibacillus
and
Levilactobacillus
were identified as differentially abundant taxa in silage sample from CD after 60 days of ensiling; in contrast, the undesirable microbiota were still the differentially abundant taxa in the silages from HY and XH. Correlation analysis further confirmed that altitude affects the epiphytic microbial structure and nutrition distribution of
E. nutans
forage, leading to varying levels of fermentation. Considering the complex microbial composition of fresh forage, LAB inoculation is highly suggested for
E. nutans
silage making in the Qinghai regions with low altitudes.

IMPORTANCE

On the Qinghai-Tibet Plateau (QTP), feed shortages are common due to cold environmental conditions and the short growing season of crops. Therefore, effective preservation, such as the ensiling of local forage, is becoming increasingly important to balance the seasonal imbalance between the forage supply and the nutritional needs of domestic animals in this area. However, the structure of the microbial community of the forage, which is influenced by climatic conditions such as altitude differences, has a major impact on the fermentation quality and microbial succession of the ensiled forage. Therefore, we investigated microbial community dynamics, co-occurrence, functional shifts, and natural fermentation profiles of
Elymus nutans
silage as a function of altitudinal gradients. Results show that silage from Chenduo at higher elevations has better fermentation quality and higher abundance of
Lacticaseibacillus
and
Levilactobacillus
than ensiled forage from other regions. This work may contribute to guiding for silage production in QTP.