bluuebunny/crossref_metadata_2025_split huggingface dataset:
Conditioned medium of IGF-1-induced human synovial membrane mesenchymal stem cells effects on inflammatory response of osteoarthritic in vitro model
Authors: Marlina Marlina , Armenia Armenia , Rahmadian Rizki , Widodo Wahyu Setia , Haddeline Syarifah Fadhlira , Safitri Maharani , Elida Nur , Widowati Wahyu 
Published: December 2023

Synovial membrane mesenchymal stem cells (SM-MSCs) possess excellent regenerative potential, making them a viable option for osteoarthritis (OA) therapy. Moreover, these cells can be easily obtained from the human body. Insulin-like growth factor (IGF-1) can be used to decrease the pro-inflammatory marker, these markers can trigger inflammation in OA. These challenges can be addressed by utilizing a conditioned medium (CM) derived from stem cell culture. This study aims to compare the effective way of OA therapy between CM SM-MSC and CM SM-MSC induced by IGF-1 by observe the pro-inflammatory markers such as NF-kB, RANTES, PGE2, COL1 and the anti-inflammatory marker, Aggrecan (ACAN). Chondrocyte cells induced IL-1β as OA model (IL1β-CHON002) treated with IGF-1 15% and 30% and without IGF1-induced SM-MSCs-CM to know its effectiveness in decreasing the pro-inflammatory markers. ELISA and RT-qPCR methods were performed to analyze this effect. Based on the data result, SM-MSCs-CM is estimated to have the potential to treat OA as seen from the content of growth factors in CM, decreasing the markers of inflammation. The most significant reduction in PGE2, RANTES, NF-kB, and COL1 concentration was found in the treatment of SM-MSCs-CM cultured with IGF1 concentrations of 150 ng/mL. The higher aggrecan (ACAN) concentration was found in IGF150 15%. Conclusion: CM from SM-MSCs cultured with IGF150 with concentrations of 15% and 30% resulted in the most effective concentration to decrease the concentration of pro-inflammatory markers and also to increase the anti-inflammatory markers.
CICLO DE NITROGÊNIO NAS BACIAS HIDROGRÁFICAS DE PERNAMBUCO: Situação atual e cenários futuros
Authors: Galvíncio Josiclêda Domiciano , Miranda Rodrigo Q. , Montenegro Suzana Maria Gico Lima , Luz Gabrielly Gregorio 
Published: December 2023

O ciclo do nitrogênio é fundamental para a produção de biomassa, que por sua vez afeta a ET-Evapotranspiração real e a produção de sedimentos. O ciclo do nitrogênio é complexo, geralmente não é possível validar essas rotinas fora de um ambiente de pesquisa. Grandes mudanças nos teores de nitrogênio inicial e final (em particular N orgânico) podem indicar fertilização insuficiente ou excessiva durante a simulação, SUPer, https://super.hawqs.tamu.edu/. Assim, considerando o exposto acima este Atlas apresenta balanços de nitrogênio médios anuais para as 13 maiores bacias de Pernambuco. No primeiro momento é apresentado a situação atual e no segundo momento foi mostrado cenários de aumento e diminuição de precipitação e aumento de temperatura. Esses resultados apresentam informações preciosas para a gestão das bacias hidrográficas do estado de Pernambuco, como também um material didático para aulas de graduação e pós-graduação que venham atuado na gestão ambiental, gestão dos recursos hídricos e os impactos ambientais. Além disso, esses resultados podem servir para comparações com outras metodologias e avanços científicos.
CICLO DE SEDIMENTO NAS BACIAS HIDROGRÁFICAS DE PERNAMBUCO: Situação atual e cenários futuros
Authors: Galvíncio Josiclêda Domiciano , Miranda Rodrigo Queiroga , Paz Yene Medeiros , Luz Gabrielly Gregorio , Montenegro Suzana Maria Gico Lima , Souza Weronica Meira 
Published: December 2023

Sabe-se que a perda de sedimentos da paisagem depende de muitos fatores. Há poucos ou nenhum dado medido para diferenciar entre sedimentos de terras altas e mudanças de sedimentos no rio. Os córregos podem ser uma fonte líquida de sedimentos ou um sumidouro. A modificação dos sedimentos no fluxo é afetada pelas características físicas do canal (inclinação, largura, profundidade, cobertura do canal e características do substrato) e pela quantidade de sedimentos e fluxo a montante. Assim, considerando o exposto acima este Atlas apresenta balanços de sedimentos médios anuais para as 13 maiores bacias de Pernambuco. No primeiro momento é apresentado a situação atual e no segundo momento foi mostrado cenários de aumento e diminuição de precipitação e aumento de temperatura. Assim, as informações aqui apresentadas são bastante valiosas uma vez que essa informação é muito escassa e de grande necessidade no momento uma vez que as mudanças climáticas podem ocasionar uma maior degradação dos solos e maior erosão hídrica.
Análise Hidromorfológica como Subsídio Para Estudo De Suscetibilidade a Escorregamento Gravitacional do Bairro de Águas Compridas, Olinda-PE
Authors: Dos Santos Freitas Carlos José , Rocha Gerlane Gomes da , Duarte Cristiana Coutinho 
Published: December 2023

O Bairro de Águas Compridas localiza-se nas áreas de morro da zona oeste do município de Olinda - PE, onde apresenta alta configuração de residências em situação de vulnerabilidade e suscetíveis a incidentes de escorregamentos gravitacionais. No estudo foram utilizadas técnicas de sensoriamento remoto e geoprocessamento para mapeamento das áreas suscetíveis a desastres. Foram utilizados também índices numéricos hidrológicos e parâmetros topográficos para mensurar a suscetibilidade da região. No presente estudo, a técnica de análise multicritério foi usada para o mapeamento de zonamento de risco de deslizamento de terra, para explicar os fatores determinantes dos últimos deslizamentos de terra ocorridos no bairro de Águas Compridas e também para alertar sobre possíveis localidades em risco de deslizamento. Com base nas análises realizadas constatou-se de zonas de risco e vulnerabilidade socioambientais e suas influências hidromorfológicas.
Índice de vulnerabilidade costeira do município de São Gonçalo do Amarante (Ceará) frente a elevação do nível do mar
Authors: Lopes Débora , Romariz Duarte Cynthia , Targino da Silva Maykon , Viana Freires Eduardo 
Published: December 2023

As imagens de satélite, submetidas a técnicas de PDI, integradas em um ambiente SIG, permitem avaliar as mudanças na paisagem, correlacionando tendências, variabilidades, permitindo uma compreensão de mudanças nas condições ambientais. Esta pesquisa determinou o Índice de Vulnerabilidade Costeira (IVC) do município de São Gonçalo do Amarante (Ceará), a fim de destacar as áreas que apresentam maior vulnerabilidade, a partir da análise de seis variáveis ​​(geomorfologia, taxa de variação das linhas de costa, inclinação costeira, amplitude média das marés, altura significativa de onda e nível médio do mar) que foram quantificáveis ​​em relação à vulnerabilidade costeira à elevação do nível do mar. Obteve-se que 63,13% da linha de costa mapeada está classificada como IVC moderado, 21,85% Muito Baixa, 8,07% como Vulnerabilidade Alta, 5,49% como Baixa e apenas 1,40% com vulnerabilidade costeira Muito Alta. A porção mais vulnerável corresponde à foz do Rio Anil, local que não apresenta comportamento linear, variando a largura da faixa de praia ao longo do ano, favorecendo a ação de eventos externos.
Konflik Sertifikat Tanah Dan Bangunan (Barang Milik Daerah) Antara Hak Masyarakat Dengan Pemerintah Kota Malang
Authors: Faisal  , Saiman  , Ali Roziqin  
Published: December 2023

Land is a important factor in human life. In human life, most of his life is very dependent on land. On land, humnas can live and build livable buildings. The existence of official residence land and buildings whose property rights are under the Malang City Government and the Ministry of Finance is a problem because the land and houses that will be built by a Government service office are still occupiet by several heirs of employees of the Malang City State Treasury Service Office who have retired. This study aims examine the dynamics of social conflict relate to Agrarian Affairs by the Community and the Government, the second is to find out how the community forms resistance to the government in defending land and building houses. This study uses a qualitative descriptive research method. The theory used is conflict theory. The results showed that the roots of land and house building conflicts were the lack of justice for the heirs of retired employees of the Malang City State treasury Service Office who had devoted themselves to the state for decades, as well as the absence of continue to occupy the land and building of the house, giving rise to a reaction from the Government to immediately vacate it.
Digital Depth: A Volumetric Speculation
Authors: De Seta Gabriele 
Published: December 2023

Counter commonplace associations with superficial mediation and networked flatness, the digital seems to have its own peculiar depths, which range from the infrastructural (deep sea cables, deep packet inspection, crawl depth) to the metaphorical (Deep Web, deep learning, deepfakes). This article reviews recent discussions of digital depth and argues that this concept is central to understanding multiple aspects of digital media ranging from folk theorizations to technical expertise. What is digital depth? What is deep about digital media? How does this depth interface with volumes and scales beyond the digital? Through this effort, depth emerges as an underlying feature of deeply mediatized societies.
Analysis of the Correlation Between Waiting Time for Prescription Services and Patient Satisfaction in Puskesmas
Authors: Yuswantina Richa , Dyahariesti Niken , Falkhatiana Wilda , Syari Nyayu Ayunda 
Published: December 2023

Â Efforts to improve and control the quality of pharmaceutical services to ensure patient satisfaction are carried out by evaluating the waiting time for prescription services in preparing pharmaceutical preparations and the level of patient satisfaction in pharmaceutical services [1]. Puskesmas is the first level health facility that participates in efforts to achieve the target of Minimum Service Standards [2]. The purpose of this study was to analyze the relationship between waiting time for prescription services and the level of patient satisfaction at the Puskesmas.Â This study used an observational research design with a design approach cross sectional. Determination of the research sample using a purposive sampling method. Analysis of the data used for this research is univariate analysis and bivariate analysis, as well as statistical chi-square test.Results: This study used an observational research design with a cross sectional design approach. Analysis of the data used for this study using the SPSS program, as well as the chi-square statistical test.Â Â Â Â Â Â Â Â Â Â Â Â Â Â According to standard waiting time for prescription service, 155 recipes (92.90%) were categorized according to standard and 11 prescriptions (7.10%) were not according to standard. The level of satisfaction of respondents was categorized as satisfied as many as 132 respondents (85.16%) while those who felt dissatisfied were 23 respondents (14.84%). From the results of the analysis of the chi-square test waiting time and the level of patient satisfaction obtained P Value <0.05.There is a relationship between waiting time for prescription services and the level of patient satisfaction at the Puskesmas.Â
Analysis of Factors Associated with the Use of Long Term Contraceptive Metode
Authors: Rahmatia Sinta Dwi , Dinengsih Sri , Lail Nurul Husnul 
Published: December 2023

The population problem faced by Indonesia is the high Population Growth Rate (LPP) and Total Fertility Rate (TFR). The use of MKJP is very appropriate to be applied to the condition of Indonesia which is experiencing population growth problems. The low use of MKJP in Indonesia is caused by many factors. In TPMB"S" Bogor, West Java in 2022, it was recorded from the register book that only 30% used MKJP. Â This study aims to Analyze Factors Related to the Use of MKJP. This type of research is correlation analytics with Cross Sectional approaches. Â The sample was 110 respondents, with random sampling. using questionnaire sheets on KB participants in TPMB "S". The results showed that respondents who had good knowledge (41.9%) using MKJP, had husband support (44.5%), despite receiving good support from health workers, had a sense of anxiety (64.6%). The test results showed thatÂ there was a relationship of knowledge to the use of MKJP itself p-value 0.044, there was a relationship between husband support and the use of MKJP p-value 0.024, there was no relationship between health workers' support and the use of MKJP p-value 0.095. and there is a relationship between anxiety and the use of MKJP Â Â Â p-valueÂ 0.014%.Â Â There is a significant association between knowledge, spousal support, and anxiety. And there is no significant relationship between the support of health workers and the use of MKJP in TPMB "S".
The Relationship Between Age and Parity With the Incidence of Chronic Energy Deficiency (KEK) in Pregnant Women
Authors: Listiana Akma , Jasa Novi Eniastina 
Published: December 2023

Â The World Health Organization (WHO) estimates that worldwide more than 585,000 women die each year during pregnancy or childbirth. The maternal mortality rate is used as an indicator to describe the level of awareness of healthy living behavior, nutritional problems and maternal health. Nutritional problems that commonly occur in pregnant women are nutritional deficiencies, both macro and micro nutritional deficiencies which are manifested in chronic energy deficiency status (KEK). Chronic Energy Deficiency (KEK) is a condition in which the mother suffers from chronic (chronic) food shortages, causing health problems for pregnant women. (Paramashanti, 2021). The average prevalence of pregnant women who experience CED in the world is 15-47% (WHO, 2012). Indonesia is a country that has moderate category of public health problems (5-9.9%) for pregnant women at risk of KEK. (Riskesdas, 2018).The design of this research is analytic with cross sectional approach. The population in this study were all pregnant women who had their pregnancy checked at PMB. Wirahayu in January-August 2022 totaled 430 people. The sample taken is the entire population of 430 people. Data analysis techniques are univariate and bivariate. Based on the results of research from 430 pregnant women, it was found that 83 pregnant women (19.3%) experienced CED. Statistical test results obtained p-value 0.015, this means that there is a relationship between parity to the incidence of KEK. Based on the age of the respondent, the results of the statistical test obtained a p-value of 0.000, which means that there is a relationship between maternal age and the incidence of Â KEK.In this study, because there are still many KEK incidence rates, regardless of parity and maternal age, it is better if pregnant women during ANC are given explanations, leaflets and descriptions of the dangers of Chronic Energy Deficiency (KEK), so that mothers can understand the impact of KEK.Â Â Â
Modern methods for identification and quantification of cardiac glycosides
Authors: Evdokimova O. V. , Beketova A. V. , Naumova O. A. , Klinkova I. V. , Shemeryankina T. B. , Ladygina L. A. , Bushchik K. S. 
Published: December 2023

Scientific relevance.Cardiac glycosides have been used in medicine for over two centuries. Current studies suggest that biologically active substances from this group can be used to treat not only heart conditions but also viral infections, cancers, and other diseases. Therefore, quality control methods for cardiac glycosides are becoming increasingly relevant.Aim.Based on a review of Russian and international quality standards, as well as up-to-date scientific data, this study aimed to identify promising methods for the identification and quantification of cardiac glycosides in herbal drugs and herbal medicinal products, as well as to evaluate the possibility of substituting physicochemical methods for biological methods.Discussion.The methods that are currently used to standardise cardiac glycosides are either not selective or require laboratory animals (biological test systems). According to a study of pharmacopoeial methods for the identification of cardiac glycosides in herbal drugs and herbal medicinal products, chemical identification tests and thin-layer chromatography continue to be relevant. Quantitative testing of herbal drugs and extracts uses biological and non-selective (spectrophotometry) methods, whereas chromatography is described only in general and individual monographs for herbal drug preparations containing individual cardiac glycosides and medicinal products containing these preparations. Upon analysing quality standards and scientific publications, the authors identified potentially promising methods for the quantification of cardiac glycosides in herbal drugs, herbal drug preparations, and herbal medicinal products, namely chromatographic methods.Conclusions.Reverse-phase high-performance liquid cjromatography (HPLC) with spectrophotometric detection is the most suitable method for pharmacopoeial analysis. The development of an HPLC-based analytical procedure to determine the cardiac glycoside content will provide an opportunity to advance from biological or non-selective methods to more ethical and selective up-to-date techniques.
Introduction and breeding of shadbush in Russia and abroad
Authors: Rengarten G. A. 
Published: December 2023

Shadbush is one of the underutilized berry crops. Originally, it was an ornamental crop, but now it is increasingly used as a food crop. Numerous species of shadbush belong to the genus Amelanchier Medik.; wild species grow in North America, Europe, as well as in Western and Eastern Asia, and each region has different species composition. The year of 1590 marked the beginning of introduction of wild shadbush species with the most valuable features to other countries. In the 19th century, the introduction of shadbush became most popular. In 1800, shadbush breeding was launched in Canada, and then in the USA. In 1937, the production of commercial varieties was established. At present, in Russia, the most productive work on introduction and breeding of shadbush is carried out in Michurinsk (All-Russian Scientific Research Institute of Horticulture named after I.V. Michurin), Novosibirsk (Central Siberian Botanical Garden of SB RAS), and Moscow (N.V. Tsitsin Main Botanical Garden). Unfortunately, the assortment of shadbush varieties in Russia is still quite limited and is represented by only two varieties. In recent years, the development of methods of shadbush clonal micropropagation has been underway, which makes it possible to obtain planting material on an industrial scale and accelerate the reproduction of rare varieties.
Social Cohesion and Religiosity – Empirical Results from an Online Survey in Germany during the COVID-19 Pandemic
Authors: Hillenbrand Carolin 
Published: December 2023

Abstract
Social scientists and development practitioners are increasingly recognizing the significance of social cohesion as a prerequisite for and part of sustainable development. At the same time, the COVID-19 pandemic poses severe challenges to the cohesion of societies. However, the specific role of people’s religiosity in their attitudes and behaviors relevant for social cohesion has rarely been empirically-quantitatively investigated.
Using primary data from an online survey in Germany, this article addresses three research questions: 1) How can the construct “social cohesion” be empirically and quantitatively measured? 2) What dynamics of social cohesion were evident in Germany during the COVID-19 pandemic (in 2020/2021)? 3) What specific role did people’s religiosity play in social cohesion in that context?
These questions are answered within a theory-led empirical analysis. Social cohesion is conceptualized as a multidimensional construct that manifests itself in horizontal (citizen–citizen) and vertical (citizen–state) relationships. It is measured by eight subdimensions: social/institutional trust, social inclusive/national identification, social/institutional responsibility, and social/political engagement. Religiosity is specified with three dimensions: belonging (religious affiliation), believing (faith intensity/content), and behaving (prayer/service attendance).
The empirical results for Germany show that the people surveyed in the period from July 2020 to January 2021 tended to hold together more. Several cohesion dimensions, particularly institutional trust and national identification, strengthened. In contrast, social trust weakened. The role of religiosity is ambivalent. It is not the intensity but the content and practices of faith that make the difference. Exclusivist religious beliefs, a punitive image of God, and private prayer practice are negatively related, while a loving image of God and service attendance are positively related to social cohesion.
Revisão da farmacoterapia intra-hospitalar: análise de risco e de rede
Authors: RAHN Barbara , ZONZINI Fernando Henrique , MENDES Antônio Matoso 
Published: December 2023

Objetivo: Analisar a relação entre os Problemas Relacionados a Medicamentos (PRM) e os medicamentos identificados no processo de revisão da farmacoterapia (RF) de um hospital universitário. Método: Trata-se de um estudo observacional retrospectivo e transversal. Os registros de PRM do período do estudo (2019-2020) foram coletados de um banco de dados de RF hospitalar e classificados conforme a Pharmaceutical Care Network Europe (PCNE). Em seguida, um painel de especialistas (farmacêuticos e médicos) analisou a significância clínica do PRM incluído, em formulário online, com base no Hazard Scoring Matrix (HSM). Utilizando o software Gephi foram construídas duas redes para visualização da relação entre os PRM e os medicamentos nas seguintes perspectivas: (i) dos farmacêuticos do hospital; e (ii) do painel de especialistas. Resultados: 1250 PRM relacionados a 177 medicamentos diferentes foram incluídos e compilados em 202 combinações diferentes de “PRM-medicamento”. Pelo PCNE 41,6% dos PRM foram classificados como classe C1 (seleção do medicamento), 20,32% como C5 (dispensação) e 13,76% da classe C3 (seleção de dose). Pelo painel de especialistas, a combinação de “seleção de dose- antibiótico” foi a que apresentou maior risco na análise global e de farmacêuticos. Para os médicos, a combinação “monitoramento - anticoagulantes antagonistas de vitamina K” foi classificada com o maior risco. Em contrapartida, a combinação “seleção do medicamento- antiulcerosos”, que foi a mais encontrada na base de dados foi classificada pelos especialistas com escore de risco baixo (HSM 6). Conclusão: A significância das combinações “PRM-medicamento” foi diferente quando comparados os resultados pré e pós análise de risco. Assim, demonstrou-se que o HSM pode ser uma ferramenta útil para melhorar a avaliação do PRM e padronizar os serviços de RF, orientando os farmacêuticos para situações de maior significância clínica e aumentando sua eficácia na melhoria dos resultados de saúde.