bluuebunny/crossref_metadata_2025_split huggingface dataset:
Metabolomic analysis of serum short-chain fatty acid concentrations in a mouse of MPTP-induced Parkinson’s disease after dietary supplementation with branched-chain amino acids
Authors: Mi Na , Ma Lili , Li Xueying , Fu Jia , Bu Xinxin , Liu Fei , Yang Fan , Zhang Yali , Yao Lifen 
Published: November 2023

Abstract
The gut microbiota and microbial metabolites influence the enteric nervous system and the central nervous system via the microbial–gut–brain axis. Increasing body of evidence suggests that disturbances in the metabolism of peripheral branched-chain amino acids (BCAAs) can contribute to the development of neurodegenerative diseases through neuroinflammatory signaling. Preliminary research has shown that longitudinal changes in serum amino acid levels in mouse models of Parkinson’s disease (PD) are negatively correlated with disease progression. Therefore, the aim of the present study was to determine the changes in serum levels of short-chain fatty acids (SCFAs) in a mouse model of 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP)-induced PD after dietary BCAA supplementation. In our research, gas chromatography–mass spectrometry was used to detect serum SCFA concentrations. The data were then analyzed with principal component analysis and orthogonal partial least squares discriminant analysis. Finally, the correlations of serum SCFA levels with gut and motor function in MPTP-induced PD mice were explored. Propionic acid, acetic acid, butyric acid, and isobutyric acid concentrations were elevated in MPTP + H-BCAA mice compared with MPTP mice. Propionic acid concentration was increased the most, while the isovaleric acid concentration was decreased. Propionic acid concentration was positively correlated with fecal weight and water content and negatively correlated with the pole-climbing duration. In conclusion, these results not only suggest that propionic acid may be a potential biomarker for PD, but also indicate the possibility that PD may be treated by altering circulating levels of SCFA.
Research progress of metal-based additive manufacturing in medical implants
Authors: Zhai Yun , Zhang Hao , Wang Jianchuan , Zhao Dewei 
Published: November 2023

Abstract
Metal-based additive manufacturing has gained significant attention in the field of medical implants over the past decade. The application of 3D-printing technology in medical implants offers several advantages over traditional manufacturing methods, including increased design flexibility for implant customization, reduced lead time for emergency cases, and the ability to create complex geometry shapes for patient-specific implants. In this review study, the working principles and conditions of metal 3D-printing technologies such as selective laser sintering, selective laser melting, and electron beam melting, as well as their applications and advantages in the medical field, are investigated in detail. The application scenarios and research status of non-degradable metals including titanium alloy, medical stainless steel, etc., and degradable metals like magnesium alloy are introduced as printing materials. We discuss the improvement of mechanical properties and biocompatibility of implants through surface modification, porous structure design, and the optimization of molding processes. Finally, the biocompatibility issues and challenges caused by the accuracy of CT imaging, fabrication, implant placement, and other aspects are summarized.
Ethik als Gegenstand der Religionswissenschaft
Authors: Hetmanczyk Philipp 
Published: November 2023

Zusammenfassung
Im deutschsprachigen Raum haben sich unterschiedliche Fachformate als Alternativen zum konfessionellen Religionsunterricht etabliert. Innerhalb dieser Fachformate kommt der Religionskunde meist ein mehr oder weniger großer Anteil zu und oftmals beteiligt sich die Religionswissenschaft an der Lehrpersonenausbildung für diese religionskundlichen Fachanteile. Neben der Religionskunde bildet jedoch auch die Ethik entweder einen Teil dieser Fächer oder das Fach als solches ist als Ethik benannt. Der vorliegende Beitrag widmet sich der Frage, inwiefern die Religionswissenschaft auch einen Beitrag zur Lehrpersonenausbildung für das Fach bzw. die Fachdimension Ethik leisten kann.
Value Determinants, Mentality and Identity of the Bosnian-Herzegovinian Village at the Beginning of the 20th Century according to Ivan Softa’s Literary Works
Authors: Tomić Draženko , Legac Vladimir 
Published: November 2023

Ivan Softa (Sopta) (1906–1945) was a Croatian writer from Bosnia and Herzegovina. In his realistic novels Dani jada i glada (Days of Misery and Hunger) (1937) and Nemirni mir (Restless Peace) (1940), as well as in his other literary achievements, he describes the life of the Herzegovinian village at the time when the First World War was about to start. It was an ambience dominated by bare stone, hot sun, sharp north wind called bora, with somewhat scarce and sparse land that made an easy life impossible. These resources that abound in this Western Balkans region also shaped the specific (Dinaric) mentality of the people of that time: hard as the stone on which they grew up, aggressive and easily flammable like the sun that they were exposed to and unrestrained like the wind, the whipping of which they mercilessly suffered from. But it happened that even from that fiery temper some kind of an original mountaineering-like honesty and confidence, empathy and readiness for self-sacrifice had emerged. Personal martyrdom turning into self-destruction – something that seems to be completely inconceivable to modern man – is embodied in the female characters, whereas emotional rawness and hardness are more characteristic of the author’s male characters. The tragic circumstances of war and famine caused emigration to regions where there was bread. These tragic circumstances resulted in the tragic fate of the characters who left the Herzegovinian environment and, like many others, fell apart on the side roads of life.
Surgical treatment of Hallux Rigidus – arthrodesis or resection arthroplasty? Retrospective observational study
Authors: Rapolis Dovydas , Urmanavičius Matas , Makulavičius Aleksas , Uvarovas Valentinas 
Published: November 2023

Introduction. Hallux Rigidus, a degenerative disease of the first metatarsophalangeal joint (MTP), causes pain during movement, reduces joint mobility, and impairs quality of life. Conservative treatment methods are effective only in the early stages of the disease, and surgical treatment is usually recommended for advanced pathology. Arthrodesis procedure is the gold standard. This surgery effectively and relatively quickly reduces painful symptoms but sacrifices joint mobility. An alternative is resection arthroplasty. There is no consensus in the literature regarding the long-term outcomes of these two treatment methods. The aim of this study is to determine which method is superior in improving patients’ quality of life and foot function. Methods. A retrospective observational study was conducted on 41 patients who were followed up for 2–4 years after surgery. Of these, 20 underwent resection arthroplasty, 21 – arthrodesis. Patients’ quality of life and subjective foot function were assessed using two standardized questionnaires: SEFAS and Short Form-12. Additional questions on patient satisfaction with the surgery were also evaluated. Results. Patient satisfaction with the surgery was high in both groups (80%). There were no statistically significant differences in patients’ ankle and foot function assessed by SEFAS scale and psychological quality of life assessed by SF 12 (Mental Score): p = 0.14 and p = 0.729, respectively. Patients rated their physical quality of life significantly better, assessed by SF 12 (Physical Score), after undergoing arthroplasty (p = 0.02), and foot function recovered approximately 1 month faster compared to arthrodesis (p = 0.006). There were no cases of revision surgery, infectious complications, or non-unions in either group. Conclusions. Both surgical techniques are effective and improve patients’ functional status, but subjective foot function is better in the early postoperative period after resection arthroplasty. The majority of patients in both groups would recommend the surgery under similar circumstances.
Preterm Birth and Infantile Appendicitis
Authors: Liu Yakun , Yu Xiaoxiao , Zhang Guoqing , Xie Chuanping , Li Yang , Mu Pengfei , Chen Shuai , Chen Yajun , Huang Shungen 
Published: November 2023

OBJECTIVE
To investigate the potential association between preterm birth and infantile appendicitis.

METHODS
We conducted a retrospective, multicenter, matched case-control study. This study included consecutive patients &lt;1 year of age with surgery- or autopsy-confirmed appendicitis, admitted between December 2007 and May 2023. For each case, 10 healthy infants were randomly selected and matched by age. Infants were categorized as neonates (0 to 28 days) or older infants (&gt;28 days and &lt;1 year).

RESULTS
The study included 106 infants diagnosed with appendicitis (median age 2.4 months) and 1060 age-matched healthy controls. In the univariate analysis, preterm birth was significantly associated with the development of appendicitis within the first year of life (odds ratio [OR], 4.23; 95% confidence interval [CI], 2.67–6.70). Other factors associated with a higher risk of infantile appendicitis included being male (OR, 1.91; 95%CI, 1.25–2.94), weight-for-age z-score (OR, 0.72; 95%CI, 0.64–0.81), and exclusively fed on formula (OR, 2.95; 95%CI, 1.77–4.91). In multivariable analyses, preterm remained significantly associated with appendicitis (adjusted OR, 3.32; 95%CI, 1.76–6.24). Subgroup analysis revealed that a preterm birth history increased the risk of appendicitis in both neonates (adjusted OR, 4.56; 95%CI, 2.14–9.71) and older infants (adjusted OR, 3.63; 95%CI, 1.72–7.65). However, preterm did not significantly influence the incidence of appendiceal perforation.

CONCLUSIONS
Preterm infants have an increased risk of appendicitis during the first year of life. A preterm birth history may help improve the timely diagnosis of infantile appendicitis.
Mobile apps used to assess and monitor nutritional status and malnutrition among seniors
Authors: Dąbek Anna , Klisowska Iwona , Seń Mariola , Zborowska Iwona , Grabowska Barbara 
Published: November 2023

Introduction. The threat of progressive malnutrition as well as the consequences thereof among seniors have become more frequent. Systematic assessment of nutritional status becomes an indispensable element of actions towards elderly people. It allows for quick detection of risks and undertaking nutritional interventions. Unfortunately, malnutrition or threat of malnutrition is often undetected or neglected in treatment. Modern applications designed for the elderly and their caregivers may be helpful in monitoring nutritional status and taking corrective actions.
Aim & methods. The purpose of this study is to present the feasibility of remote assessment and monitoring of nutritional status with particular emphasis on the state of malnutrition. This paper attempts to present available applications for early identification of risks and initiation of nutrition interventions and actions based on analysis of solutions available or developing in Poland.
Results. In recent years, progress has been made in the field of e-health, with applications and programs dedicated to health and prevention that allow the users to increase control over their own health (Łukasik, 2021). There are applications available that allow one to calculate body weight, plan a diet, check the calorific value of products, their glycemic index, calculate the nutritional value of a meal or analyse the body composition, thus effectively allowing the user to control malnutrition.
Conclusion. A senior care program for the prevention or treatment of malnutrition must involve a physician, a nurse, a dietician, a psychologist, a physiotherapist, as well as the caregiver of the elderly person and the senior themselves. In Poland, programs aimed at improving the health of seniors have been implemented, also in the area of malnutrition, but the scale of the problem is still large.
Methods for experimental design, central composite design and the Box–Behnken design, to optimise operational parameters: A review
Authors: Szpisják-Gulyás N. , Al-Tayawi Aws N. , Horváth Zs. H. , László Zs. , Kertész Sz. , Hodúr C. 
Published: November 2023

AbstractIn recent years response surface analysis has been increasingly used to optimise membrane separation. It has many advantages, such as reducing the number of experiments to be performed, which requires lower energy consumption and significantly less laboratory work. For more accurate data analysis and forecasting, mathematical models are used that analyse the relevance of the factors examined and the interaction effects between the factors. In this research, two experimental designs that use response surface methodology are presented, namely, the central composite design and the Box–Behnken design. After the general characterisation of the experimental designs, their application in membrane technology is presented.
The potential of psilocybin use to enhance well-being in healthy individuals – A scoping review
Authors: Wiepking Lennart , de Bruin Ed , Ghiţă Alexandra 
Published: November 2023

AbstractBackground and aimsThis scoping review employed a multifaceted conceptualization of well-being to examine how psilocybin use affects well-being and related sub-concepts in healthy individuals. It investigated which factors influence the relationship between psilocybin use and well-being, what research protocols have been employed, and what underlying mechanisms have been proposed in existing studies.MethodsA comprehensive literature search in line with the PRISMA guidelines was conducted. Scopus, PubMed, PsycINFO, Web of Science, and Google Scholar were searched for peer-reviewed articles about psilocybin and well-being in healthy populations.ResultsStudies were heterogeneous in regard to study objectives, study design, study procedure, sample size and psilocybin dosage. In all studies, psilocybin use led to positive well-being-related outcomes for the majority of participants. Facets of well-being positively affected by psilocybin use in this review were self-acceptance, positive relationships, and meaning/purpose in life.ConclusionsThis scoping review provided preliminary evidence for the beneficial effects of psilocybin on well-being and related sub-concepts such as self-acceptance, positive relationships, and meaning/purpose in life in healthy individuals. Ego-dissolution, unity, connectedness, and mystical-type experiences are interrelated concepts that seem to be crucial for explaining such positive well-being-related effects of psilocybin. Under conducive conditions, the use of psilocybin may contribute to healthy functioning, through broad and sustained improvements in a variety of well-being concepts. Due to the heterogeneous nature of the studies, more definite conclusions require further research with a rigorous and homogeneous design.
Low-temperature silver-based ink for highly conductive paths through industrial printing processes suitable for thermally sensitive substrates and beyond
Authors: Lepak-Kuc Sandra , Nowicka Tatiana , Wasilewska Katarzyna , Janczak Daniel , Walter Piotr , Jakubowska Małgorzata 
Published: November 2023

AbstractPrinted electronics is experiencing tremendous growth in applications and industry interest worldwide. One of the most frequently raised problems is the high curing temperature of commercially available conductive composites. This study describes the process of developing a customized low-temperature silver-based, conductive ink dedicated to the flexographic-printing technique. The formulation was optimized through a series of tests including printing trials, resistance measurements, evaluation of printed samples surface features, and mechanical properties. The appropriate ink viscosity, substrate compatibility, and sinterability at low temperatures were achieved. The dependence of the achieved conductivity on the type of raw materials used was also witnessed and described. The conductivity of the printed inks was evaluated for various polymer vehicles. Samples printed on flexible PET and paper substrates were thoroughly investigated; ink adhesion, scratch resistance, and performance after cyclic bending have been assessed.
Graphical abstract
Czy duchowny diecezjalny może pozwać prowincjała i prowincję przed sąd diecezjalny?
Authors: Karsten Kinga 
Published: November 2023

W tym artykule przedstawiony został kazus dotyczący kanonicznego prawa procesowego. Autorka odpowiada twierdząco na tytułowe pytanie: Czy duchowny diecezjalny może pozwać prowincjała i prowincję przed sąd diecezjalny? Przedstawia argumenty prawne oparte głównie na wykładani przepisów, uzasadniające ten pogląd.
DISPORA HOMO-SAPIENS BERBARISKAN MANUSIA PELAUT DI KEPULAUAN ASIA TENGGARA DAN LAHIRNYA TEORI MANUSIA KELUAR JAWA ( THEORY OUT OF JAVA-MAN) : SATU PEMIKIRAN DARI PERSPEKTIF KELAUTAN
Authors: Ali Ismail , Supriatna Encep 
Published: November 2023

Traditionally, seas and oceans have become sources of inspiration in seeking the truth from facts to dispell the worldview of those who tended to asscoiate it with myths and superstitions. In fact, it is not far-fetched to suggest that the change and development in present day Southeast Asia, from traditional kingdoms to modern nation-states are intimately rooted in and shaped by the contributions of our seafaring ancestors. History demonstrates how they risked as well as as sacrificed their lives crossing treacherous waters and encountering stormy weathers just to ensure their legacy and continuity of the future generations of seafarers, and turning this region into an epicentre of civilization that was second to none in the world of civilizations. Yet, their thousands of years of contributions and sacrifices appear trivial and paled to insignificance like ”shipwrecks laying at the bottom of the sea in their forgotten watery graves”. Based on several theories of the development of traditional civilizations in the Nusantara like the Out of Yunan and Out of Taiwan theories by western scholars, it appears that these theoretical paradigms have marginalized the realities of history, and therefore require to be ”straightened” via a Southeast Asia centric perspective. This writing is to revisit the salience of the ancient epoch and pre-historic man marked by the arrival of the homo-eractus and homo-sapiens from mainland Asia to this region in the early journey and development of the history of maritime civilization; to explain how the seafaring communities from the eras B.C. (Before Christ) to A.D. (Anno Domini) were able to utilise seas and oceans as a source of emancipation and development, and eventual rise as feared and respected searfarers of the ancient world.
APPLICATION OF JIGSAW-TYPE COOPERATIVE LEARNING MODEL TO IMPROVE LEARNING OUTCOMES
Authors: Anggrainy Rani , Tresdiawan Rendi Ardi , Mubarak Ibnu , Sutia Iyep , Lubi Ahmad 
Published: November 2023

This study aims to (1) find out the difference in improving student learning outcomes between those who use the jigsaw-type cooperative model and students who use the lecture model, and (2) find out the increase in student learning outcomes after applying the cooperative learning model with jigsaw type. Metode penelitian yang digunakan adalah metode eksperimental. The experimental method is used to look for a causal relationship between two factors that the researcher deliberately caused. The population in this study was all Class XI students majoring in Motorcycle Business Engineering at one of the State Vocational Schools in Bandung totaling 5 classes. The research samples were taken in two classes, namely one experimental class and one control class, the sampling technique was carried out random sampling cluster. The instruments used are test instruments and obsrvation sheets. The results showed that there was a significant difference between the learning outcomes of students who used a jigsaw-type cooperative model and students who got learning with a lecture model. The average final score of learners using the jigsaw-type cooperative model was higher than those using lectures. The N-Gain value index of the jigsaw type cooperative model category is quite effective and the lecture model of its N-Gain index category is ineffective.Keywords: Learning Model; cooperative; jigsaw; Experimental; N-Gain
Pengaruh Modifikasi Media Latihan Menggunakan Pipa Air Terhadap Kemampuan Shooting Dalam Olahraga Petanque Pada Atlet Petanque Sumedang Tahun 2023
Authors: Lestari Elsa Listi , Budi Dadang , Nugraha Angga 
Published: November 2023

Penelitian ini dilatar belakangi oleh belum konsistennya kemampuan shooting atlet dalam pertandingan shooting game dalam petanque. Penelitian ini bertujuan untuk mengetahui pengaruh modifikasi media latihan menggunakan penghalang berupa pipa air terhadap peningkatan kemampuan shooting atlet petanque Sumedang. Penelitian ini menggunakan metode eksperimen dengan desain two group pretest postest design. Instrumen yang digunakan untuk tes kemampuan shooting adalah permainan nomor shooting figure 1,2,3,4, dan 5 dengan jarak 6 meter, 7 meter, 8 meter, dan 9 meter. Subjek dalam penelitian ini adalah atlet petanque Sumedang yang berjumlah 20 atlet. Sampel yang diambil dari hasil purposive sampling. Tujuan penelitian ini dapat di jadikan bahan keberhasilan pelaksanaan latihan shooting terhadap pengaruh modifikasi media latihan menggunakan penghalang berupa pipa air terhadap peningkatan kemampuan shooting atlet petanque Sumedang, sehingga bahan modifikasi ini dapat di aplikasikan sama pelatih demi mencapai keberhasilan atlet. Populasi dari penelitian ini adalah atlet petanque Sumedang dengan jumlah 20 atlet dan di jadikan sample penelitian. Metode yang digunakan dalam penelitian ini adalah eksperimen dengan menggunakan instrument yaitu tes shooting. Data diambil dari tes awal dan tes akhir. Berdasarkan hasil pengolahan data, besarnya peningkatan kemampuan hasil pengaruh modifikasi media latihan menggunakan penghalang berupa pipa air terhadap peningkatan kemampuan shooting atlet petanque Sumedang dengan metode eksperimen ini di buktikan dengan uji peningkatan yang menunjukan hasil yang signifikan. Pada taraf nyata (20-1) = 19 (α) = 0,05 (thitung ttabel yaitu 137,5 1,729). Dengan demikian modifikasi latihan shooting memberikan pengaruh yang signifikan ketepatan shooting petanque pada atlet petanque Kabupaten Sumedang.
Prevalência de aleitamento materno exclusivo e fatores associados em um município do extremo sul catarinense
Authors: Fermiano Cássia Aparecida Machado Miguel , Schäfer Antônio  Augusto , Soratto Jacks , Meller Fernanda Oliveira 
Published: November 2023

Identificar a prevalência de aleitamento materno exclusivo e fatores relacionados durante os seis
primeiros meses de vida do lactente. Trata-se de um estudo transversal realizado com 102 nutrizes
residentes no município de Balneário Gaivota(SC) que efetivaram o pré-natal na rede pública ou privada
e tiveram parto no ano de 2018. Os dados foram coletados por aplicação de questionário contemplando
as variáveis sociodemográficas, gestacionais e pós-gestacionais. A prevalência de aleitamento materno
exclusivo foi de 43,1%. Aqueles bebês que usavam mamadeira tiveram 45% menos probabilidade de ter
recebido aleitamento materno exclusivo até os 6 meses de idade, e aqueles que receberam prescrição de
fórmula infantil na alta hospitalar apresentaram 54% menos chance comparados aos seus pares. Os fatores
relacionados ao aleitamento materno exclusivo são comportamentais e modificáveis, sendo necessária a
orientação pelos profissionais de saúde durante a consulta pré-natal, puericultura e no acompanhamento
do desenvolvimento infantil