bluuebunny/crossref_metadata_2025_split huggingface dataset:
Comments regarding “Seismic damage analysis due to near‐fault multipulse ground motion” by Guan Chen, Jiashu Yang, Ruohan Wang, Kaiqi Li, Yong Liu, Michael Beer; Earthquake Engineering & Structural Dynamics, 2023
Authors: Hariri‐Ardebili Mohammad Amin 
Published: November 2023

AbstractThis discussion is based on the paper by Chen et al. in 2023 (hereafter referred to as “the original paper/authors”). In their study, the original authors conducted a series of analyses using nonpulse, single‐pulse, and multipulse ground motion records, evaluating their impact on a frame structure, a slope, and a gravity dam. Their key finding suggests that multipulse ground motion leads to more severe structural damage compared to nonpulse and single‐pulse ground motions. However, it is important to note that the seismic damage analysis of the gravity dam in this paper does not adhere to state‐of‐the‐practice recommendations. Consequently, drawing a definitive conclusion regarding the influence and importance of multipulse ground motion records on the seismic response of concrete dams requires further justification. This necessitates the incorporation of high‐fidelity numerical models and probabilistic performance evaluation. We will discuss the significance of modeling assumptions, specifically addressing the dam–rock dynamic interaction in crack propagation and failure in dams.
A review of the distal femur in Australopithecus
Authors: Miller Catherine K. , DeSilva Jeremy M. 
Published: November 2023

AbstractIn 1938, the first distal femur of a fossil Australopithecus was discovered at Sterkfontein, South Africa. A decade later, another distal femur was discovered at the same locality. These two fossil femora were the subject of a foundational paper authored by Kingsbury Heiple and Owen Lovejoy in 1971. In this paper, the authors discussed functionally relevant anatomies of these two fossil femora and noted their strong affinity to the modern human condition. Here, we update this work by including eight more fossil Australopithecus distal femora, an expanded comparative dataset, as well as additional linear measurements. Just as Heiple and Lovejoy reported a half‐century ago, we find strong overlap between modern humans and cercopithecoids, except for inferiorly flattened condyles and a high bicondylar angle, both of which characterize modern humans and Australopithecus and are directly related to striding bipedalism. All other measured aspects of the femora are by‐products of these key morphological traits. Additional fossil material from the early Pliocene will help to inform the evolution of the hominin distal femur and its condition in the Pan‐Homo common ancestor that preceded bipedal locomotion.
Class‐imbalanced financial distress prediction with machine learning: Incorporating financial, management, textual, and social responsibility features into index system
Authors: Song Yinghua , Jiang Minzhe , Li Shixuan , Zhao Shengzhe 
Published: November 2023

AbstractFinancial distress prediction (FDP) is centrally imported to reduce potential losses of companies and investors. This paper combines social responsibility indicators with financial, management, and textual indicators to construct a multi‐dimensional FDP index system. To increase prediction accuracy, the difference in the number of samples between special treatment and health companies is actively considered, and the synthetic minority oversampling technique is adopted to deal with class‐imbalanced datasets. Moreover, a feature extraction method based on the genetic algorithm is employed to select features as input of machine learning models for predicting financial distress in Chinese listed companies. Experimental results show that ensemble classifiers are the better choice for predicting financial distress, of which gradient boosting decision tree outperforms other classifiers. Textual indicators play the most significant role in complementing traditional financial indicators of FDP, and their financial distress signals emerge earlier compared with management and social responsibility indicators.
Identification of bioactive compounds and inhibitory effects of TNF‐α and COX‐2 in the extract from cultured three‐spot seahorse (H. trimaculatus)
Authors: Chen Yung‐Husan , Chang Yu‐Wei , Ma Chu‐Wen , Luo Lian‐Zhong , Lu Ting‐Jang , Yao Jeng‐Yuan 
Published: November 2023

AbstractThree‐spot seahorse (Hippocampus trimaculatus) has been consumed as traditional Chinese medicine in Asian society. This study was designed to analyze the bioactive compounds of the solvent extracts from cultured three‐spot seahorse by high pressure liquid chromatography coupled with electrospray ionization tandem mass spectrometry (HPLC‐ESI/MS/MS). Subsequently, their biological activities were evaluated and confirmed by cell modes and Western blot analysis. Experimental results indicated that taurine and arginine were the primary bioactive compounds identified and quantified without pre‐ or post‐column derivatization within 20 min retention time. The analytical method was established and validated with intraday/interday RSD from 0.25% to 3.34% and with recovery from 87.8% to 91.2%. As compared to other extracts, water layer extract (WLE) contained the most taurine and arginine contents of 6.807 and 0.437 mg/g (dry basis), respectively. In the meanwhile, WLE also showed anti‐inflammatory activity on LPS‐induced NO production and inhibited the protein expression of TNF‐α and COX‐2 by Western blot analysis with better cell viability.
Development and full system testing of novel co‐impregnated La0.20Sr0.25Ca0.45TiO3 anodes for commercial combined heat and power units
Authors: Price Robert , Bausinger Holger , Longo Gino , Weissen Ueli , Cassidy Mark , Grolig Jan G. , Mai Andreas , Irvine John T. S. 
Published: November 2023

AbstractOver the past decade, the University of St Andrews and HEXIS AG have engaged in a highly successful collaborative project aiming to develop and upscale La0.20Sr0.25Ca0.45TiO3 (LSCTA‐) anode “backbone” microstructures, impregnated with Ce0.80Gd0.20O1.90 (CG20) and metallic electrocatalysts, providing direct benefits in terms of performance and stability over the current state‐of‐the‐art (SoA) Ni‐based cermet solid oxide fuel cell (SOFC) anodes.Here, we present a brief overview of previous work performed in this research project, including short‐term, durability, and poison testing of small‐scale (1 cm2 area) SOFCs and upscaling to full‐sized HEXIS SOFCs (100 cm2 area) in short stacks. Subsequently, recent results from short stack testing of SOFCs containing LSCTA‐ anodes with a variety of metallic catalyst components (Fe, Mn, Ni, Pd, Pt, Rh, or Ru) will be presented, indicating that only SOFCs containing the Rh catalyst provide comparable degradation rates to the SoA Ni/cerium gadolinium oxide anode, as well as tolerance to harsh overload conditions (which is not exhibited by SoA anodes). Finally, results from full system testing (60 cells within a 1.5 kW electrical power output HEXIS Leonardo FC40A micro‐combined heat and power unit), will be outlined, demonstrating the robust and durable nature of these novel oxide electrodes, in addition to their potential for commercialization.
Reconstruction of fluvio‐lacustrine landscapes and settlement history in the Texcoco region, Mexico, using a modern geomorphic analog
Authors: Wogau Kurt H. , Cordova Carlos E. , Morett‐Alatorre Luis , Ochoa Guillermo Acosta 
Published: November 2023

AbstractLocated in the Basin of Mexico, the eastern shore of former Lake Texcoco sustained a variety of human occupations throughout the Holocene, including preceramic hunter‐gatherers, incipient agriculturalists, and a variety of settlements in the ceramic periods. Nonetheless, the environmental dynamics of occupations on the lakeshore have not been fully addressed. The Archaic preagricultural Texcoco Man site (>5000 B.C.E.) and the Late Formative TX‐LF‐14 site (c. 550‐200 B.C.E.), among others, occupy this fluvio‐lacustrine transitional environment. Few stratigraphic works in and around the sites have been performed. Consequently, it is difficult to understand the dynamics of the sedimentary system in space and time. This work highlights and describes the fluvio‐lacustrine sedimentary dynamics and the resulting landscape that past societies inhabited on the eastern shore of Texcoco Lake. Because the study area has been altered by historic and modern draining, our work employs Lake Santiaguillo and its main tributary, the Tejamen River in the Durango state, as a modern analog to study their sedimentary dynamics. The analyses of surface geomorphology in the Texcoco study area were employed to corroborate the modern analog interpretation. To achieve these goals, we conducted a GIS‐based morphometric analysis and LANDSAT‐8 imagery to study the variations in landforms through wet and dry events. The results indicate an increase in the lake volume, low bifurcation in the active fluvial channels, few inundated surfaces, and the presence of bird‐foot deltaic channels during high precipitation events. In contrast, low precipitation events are characterized by reduced lake volume, increased fluvial channel bifurcation, and expanded floodplains. This heterogeneous landscape thus provided a rich source of diverse natural resources of saline and freshwater aquatic habitats. Simultaneously, constant or recurring flooding events generated a challenging landscape for prehistoric settlers who implemented diverse technologies, such as the construction of tlateles, on the levees of deltaic channels to reduce the risk and impact of flooding events.
An alternative p‐y method for piles in cohesive soils under monotonic lateral loading
Authors: Terceros Mauricio , Achmus Martin 
Published: November 2023

AbstractPiles as onshore and offshore foundation structures are often horizontally loaded. The usual calculation method for the behaviour of piles under such loads is the p‐y method. For piles in cohesive soil, several p‐y methods are proposed in literature, leading in general to differing results. A finite element model dealing with the behaviour of horizontally loaded piles in clay soils was established and validated against field tests. Utilising the results of a vast number of numerical simulations, a new p‐y method was developed, which gives reasonable results over the entire range of possible loads for piles of almost arbitrary diameters and embedded lengths in clay soils of varying consistency. The method requires in total six soil parameters and accounts for the actual deflection of the pile and also the effect of pile tip shear resistance by iteratively adapted y‐multipliers which depend on the course of the deflection line and the distance of the considered point to the pile tip. The new method can be generally used for calculation of the bearing behaviour of piles in soft clay under monotonic loading and can serve as a reference for consideration of cyclic load effects or softening effects in stiff clays.
Cortical gray to white matter signal intensity ratio as a sign of neurodegeneration and cognition independent of β‐amyloid in dementia
Authors: Xu Xiaomeng , Jang Ikbeom , Zhang Junfang , Zhang Miao , Wang Lijun , Ye Guanyu , Zhao Aonan , Zhang Yichi , Li Biao , Liu Jun , Li Binyin ,   for the Alzheimer's Disease Neuroimaging Initiative
Published: November 2023

AbstractCortical gray to white matter signal intensity ratio (GWR) measured from T1‐weighted magnetic resonance (MR) images was associated with neurodegeneration and dementia. We characterized topological patterns of GWR during AD pathogenesis and investigated its association with cognitive decline. The study included a cross‐sectional dataset and a longitudinal dataset. The cross‐sectional dataset included 60 cognitively healthy controls, 61 mild cognitive impairment (MCI), and 63 patients with dementia. The longitudinal dataset included 26 participants who progressed from cognitively normal to dementia and 26 controls that remained cognitively normal. GWR was compared across the cross‐sectional groups, adjusted for amyloid PET. The correlation between GWR and cognition performance was also evaluated. The longitudinal dataset was used to investigate GWR alteration during the AD pathogenesis. Dementia with β‐amyloid deposition group exhibited the largest area of increased GWR, followed by MCI with β‐amyloid deposition, MCI without β‐amyloid deposition, and controls. The spatial pattern of GWR‐increased regions was not influenced by β‐amyloid deposits. Correlation between regional GWR alteration and cognitive decline was only detected among individuals with β‐amyloid deposition. GWR showed positive correlation with tau PET in the left supramarginal, lateral occipital gyrus, and right middle frontal cortex. The longitudinal study showed that GWR increased around the fusiform, inferior/superior temporal lobe, and entorhinal cortex in MCI and progressed to larger cortical regions after progression to AD. The spatial pattern of GWR‐increased regions was independent of β‐amyloid deposits but overlapped with tauopathy. The GWR can serve as a promising biomarker of neurodegeneration in AD.
Group concerns and communication and cooperation between practitioners under the European Insolvency Regulation (Part I)
Authors: Pepels Sid 
Published: November 2023

AbstractIn this article, the author examines with a specific focus on the Insolvency Practitioner to what extent the Recast European Insolvency Regulation's provisions on communication, cooperation and coordination between the main actors in group companies' insolvency proceedings allow for efficient restructurings of those group companies. In doing so, the author will, at points, compare the provisions in Chapter V of the Recast European Insolvency Regulation to—and draw inspiration from—the German provisions on groups of companies that were adopted into the German Insolvency Act (Insolvenzordnung) and the United Nations Commission on International Trade Law's Model Law on Enterprise Group Insolvency. The author also aims to outline, among other things, the various forms of (cross‐border) communication, cooperation and coordination that the Recast European Insolvency Regulation obligates insolvency practitioners of groups of companies to engage in, how they should implement those forms of ‘CoCo’ and what would happen if they fail to comply with those obligations. This article is Part I of a diptych on this topic, Part II of which will be published in a subsequent issue of this journal.
Role of clinicopathological variables in predicting recurrence and survival outcomes after surgery for non‐metastatic renal cell carcinoma: Systematic review and meta‐analysis
Authors: Majdoub Muhammad , Yanagisawa Takafumi , Quhal Fahad , Laukhtina Ekaterina , von Deimling Markus , Kawada Tatsushi , Rajwa Pawel , Bianchi Alberto , Pallauf Maximilian , Mostafaei Hadi , Chlosta Marcin , Pradere Benjamin , Karakiewicz Pierre I. , Schmidinger Manuela , Rub Ronen , Shariat Shahrokh F. 
Published: November 2023

AbstractRenal cell carcinoma (RCC) represents 2% of all diagnosed malignancies worldwide, with disease recurrence affecting 20% to 40% of patients. Existing prognostic recurrence models based on clinicopathological features continue to be a subject of controversy. In this meta‐analysis, we summarized research findings that explored the correlation between clinicopathological characteristics and post‐surgery survival outcomes in non‐metastatic RCC patients. Our analysis incorporates 99 publications spanning 140 568 patients. The study's main findings indicate that the following clinicopathological characteristics were associated with unfavorable survival outcomes: T stage, tumor grade, tumor size, lymph node involvement, tumor necrosis, sarcomatoid features, positive surgical margins (PSM), lymphovascular invasion (LVI), early recurrence, constitutional symptoms, poor performance status (PS), low hemoglobin level, high body‐mass index (BMI), diabetes mellitus (DM) and hypertension. All of which emerged as predictors for poor recurrence‐free survival (RFS) and cancer‐specific survival. Clear cell (CC) subtype, urinary collecting system invasion (UCSI), capsular penetration, perinephric fat invasion, renal vein invasion (RVI) and increased C‐reactive protein (CRP) were all associated with poor RFS. In contrast, age, sex, tumor laterality, nephrectomy type and approach had no impact on survival outcomes. As part of an additional analysis, we attempted to assess the association between these characteristics and late recurrences (relapses occurring more than 5 years after surgery). Nevertheless, we did not find any prediction capabilities for late disease recurrences among any of the features examined. Our findings highlight the prognostic significance of various clinicopathological characteristics potentially aiding in the identification of high‐risk RCC patients and enhancing the development of more precise prediction models.
The impact of pharmacists on medication safety in mental health: A narrative review
Authors: Khartabil Nadia , Haghparast Parna , Al‐Chokachi Zahra , Clemens Emily 
Published: November 2023

AbstractBackgroundPharmacists' role in providing favorable patient outcomes has been established in previous literature. However, the impact of pharmacists in treating patients with mental illness needs further investigation. Patients diagnosed with mental illnesses face multiple challenges that affect their quality and longevity of life compared to the general population with similar age groups. Previous studies confirmed that drug related problems (DRPs) play a major role in these patients due to several factors, such as medication errors and drug interactions. The purpose of this review is to investigate the impact of pharmacist‐led initiatives in safe medication use for mental health populations.MethodsThis narrative review examines the extent and nature of the literature on pharmacist‐led interventions related to medication safety with mental health conditions. The PubMed, Embase, PsycINFO, and Cumulative Index to Nursing and Allied Health Literature (CINAHL) databases were searched from January 2000 until September 2023. A manual search of relevant citations was also conducted. The inclusion criteria included full‐text studies written in English and published within the above date range. Studies exploring pharmacist‐led interventions in any practice setting for patients with mental illnesses were included. Pharmacist‐led interventions as part of an interdisciplinary team were excluded.ResultsA total of 13 studies were included, collectively involving 4488 patients and 51 pharmacists. The most described interventions included DRPs, medication adherence, and appropriate prescribing. Pharmacist‐led interventions were presented in various aspects, including medication therapy management, long‐acting antipsychotic medication administration, and DRPs resolution through clinical interventions as transition of care.ConclusionThe variation in healthcare settings and regulatory environments influenced the effectiveness of pharmacist‐led interventions. Pharmacists can depict DRP, prevent rehospitalizations, and assess any serious drug interactions that prevent harm and consequently have cost saving outcomes. This review highlights the need for more research, to quantify the impact of pharmacists in improving medication safety for mental health patients.
Navigating obstacles: Perspectives of US pharmacy residency directors on non‐US candidates for PGY‐1 residencies: A survey‐based research
Authors: Lu Chi‐Hua , Prescott Gina M. , Slazak Erin M. , Wasim Ume Farwa , Rauf Maha , Desai Kalpesh J. , Kuo Tzu‐Yin , Cai Lijian , Bednarczyk Edward M. 
Published: November 2023

AbstractIntroductionPharmacy education and postgraduate training in the United States (US) are esteemed, drawing international students to American Council for Pharmacy Education (ACPE)‐accredited schools and pursuing residency training after graduation. Despite this, limited literature addresses the obstacles international students face in pursuing American Society of Health‐System Pharmacists (ASHP) accredited residency programs.ObjectivesTo summarize potential eligibility barriers for international graduates of ACPE programs during the residency application process from residency program directors' (RPDs) perspectives.MethodsA 16‐question electronic survey was developed and distributed to all RPDs of US‐based ASHP‐accredited postgraduate year‐1 (PGY‐1) programs in July 2021. Questions addressed whether non‐US citizens were eligible to apply, barriers to recruiting non‐US citizen candidates, and barriers to offer visa sponsorships. Descriptive statistics were used to summarize the data.ResultsA total of 196 programs responded to the survey (response rate, 13.5%). Eighty‐nine (45.4%) programs reported that candidates with F‐1/optional practical training (OPT) status were eligible to apply for their program, while 86 programs (43.9%) reported candidates were not eligible. Barriers for recruiting candidates with F‐1/OPT status included lack of resources to support application process (n = 42), citizenship requirements (n = 41), institution policy (n = 33), department preference (n = 12), and unfamiliar with procedures in selecting these candidates (n = 18). Over 70% (n = 146) would not offer visa sponsorship for pharmacy resident positions. Barriers to offering sponsorship were lack of support resources (n = 62), cost (n = 60), time preparing applications (n = 46), citizenship requirements (n = 45), and department preference (n = 23).ConclusionThis study investigates the obstacles encountered by non‐US citizens in the residency application process, as perceived by program directors. The primary obstacle in recruiting candidates with F‐1/OPT status and providing visa sponsorships revolves around the inadequate support and resources available for the application process.
Femtosecond optical Kerr effect in normal and grades of cancerous breast tissues as a new optical biopsy method
Authors: Meyer Henry J. , Mamani Sandra , Li Zhi , Shi Lingyan , Alfano Robert R. 
Published: November 2023

AbstractThis study reports on the first use of the optical Kerr effect (OKE) in breast cancer tissue. This proposed optical biopsy method utilizes a Femtosecond Optical Kerr Gate to detect changes in dielectric relaxation and conductivity created by a cancerous infection. Here, the temporal behavior of the OKE is tracked in normal and cancerous samples of human and mouse breast. These tissues display a double peaked temporal structure and its decay rate changes depending on the tissue's infection status. The decay of the secondary peak, attributed to ultrafast plasma response, indicates that the tissue's conductivity has doubled once infected. A slower molecular contribution to the Kerr effect can also be observed in healthy tissues. These findings suggest two possible biomarkers for the use of OKE in optical biopsy. Both markers arise from alterations in the infected tissue's cellular structure, which changes the rate at which electronic and molecular processes occur.