bluuebunny/crossref_metadata_2025_split huggingface dataset:
A Systematic Review of the COVID Vaccine's Impact on the Nervous System
Authors: Yella Viswarupachari Tanguturi , Pareek Sumit , Meena Bhumika , Sasanka K.S.B.S. Krishna , Thangaraju Pugazhenthan , T Y Sree Sudha 
Published: January 2024

Aims & Objectives:
The objective of this study was to conduct a systematic review of
research pertaining to the COVID-19 vaccine and its association with neurological complications.

Method:
We performed a comprehensive search of the We performed a comprehensive search of the literature using Google Scholar, PubMed,
and NCBI databases from December 2021 to December 2022. For Google Scholar, PubMed, and
NCBI databases we used the following key search terms: “neurological adverse effects”,
“COVID-19 vaccination”, “SARS-CoV-2”, CNS complications, and CNS adverse effects. Two
reviewer authors individually searched and assessed the titles and abstracts of all articles. The
third reviewer resolved the disagreement between them. Data were documented regarding title,
study location, type of study, type of COVID-19 vaccine, type of neurological complications/
adverse effects, and sample size.

Results:
From our findings, it is confirmed that these neurological complications like Guillain-
Barre syndrome (23.6%), Neuromyelitis Optica spectrum disorder (5.5%), Neuropathy (6.9%),
Transverse Myelitis (8.3%) and Acute disseminated Encephalomyelitis (4.1%) are majorly affected
in most of the people. The increase in risks associated with SARS-CoV-2 infection far
outweighs any previously reported associations with vaccination.

Conclusion:
We found no safety signal was observed between COVID-19 vaccines and the immune-
mediated neurological events. Before assuming a causal relationship, the side effects of the
COVID-19 vaccine should first be carefully examined to rule out known associated factors.
Symptom onset was within two weeks of vaccination in the majority of cases; as such, this seems
to be a high-risk period warranting vigilance.
Sulfonamide Derivatives: Recent Compounds with Potent
Anti-alzheimer’s Disease Activity
Authors: Egbujor Melford Chuka 
Published: January 2024

Abstract:
Facile synthetic procedures and broad spectrum of biological activities are special attributes
of sulfonamides. Sulfonamide derivatives have demonstrated potential as a class of compounds
for the treatment of Alzheimer's disease (AD). Recent sulfonamide derivatives have been reported as
prospective anti-AD agents, with a focus on analogues that significantly inhibit the function of acetylcholinesterase
(AChE) and butyrylcholinesterase (BChE) enzymes and exhibit remarkable antioxidant
and anti-inflammatory properties, all of which are critical for the treatment of AD. Sulfonamide-
mediated activation of nuclear factor erythroid 2-related factor 2 (NRF2), a key regulator of the
endogenous antioxidant response, has also been suggested as a potential therapeutic approach in AD.
Additionally, it has been discovered that a number of sulfonamide derivatives show selectivity for
the β- and γ-secretase enzymes and a significant reduction of amyloid B (Aβ) aggregation, which
have been implicated in AD. The comparative molecular docking of benzenesulfonamide and
donepezil, an AD reference drug showed comparable anti-AD activities. These suggest that sulfonamide
derivatives may represent a new class of drugs for the treatment of AD. Thus, the current review
will focus on recent studies on the chemical synthesis and evaluation of the anti-AD properties,
molecular docking, pharmacological profile, and structure-activity relationship (SAR) of sulfonamide
derivatives, as well as their potential anti-AD mechanisms of action. This paper offers a thorough
assessment of the state of the art in this field of study and emphasizes the potential of sulfonamide
derivatives synthesized during the 2012–2023 period as a new class of compounds for the
treatment of AD.
Interaction Effects Between Intentional Poison, Suicide Attempts,
Psychological Disorders, and Gender Using Log-linear Models
Approach
Authors: Veisani Yousef , Kheiry Maryam , Sayyadi Hojjat , Moradi Ghobad 
Published: January 2024

Background:
Based on research evidence, intentional poisoning has a relatively
high prevalence among people with psychiatric disorders, and the diagnosis of psychological
disorders can be an important predictor of suicide attempts and their recurrence. Gender
presents a determinant in the occurrence of psychiatric conditions and suicidal behaviors.

Objective:
This study aimed to investigate the relationship between suicide attempts, psychiatric
disorders, and gender in individuals hospitalized due to intentional poisoning.

Methods:
This study used the data obtained from the disease registration program based on
the data of the patients hospitalized due to intentional poisoning during a two-year followup
(2021-2022), including a total of 658 patients. In this study, log-linear models were
used to assess the relationships between the main variables that independently entered the
model. The outputs of the log-linear model we reanalyzed as independent, two-way, threeway,
and saturated models using relevant fit indices. Finally, the results of the best model
were presented.

Results:
Based on the conditional values retrieved from the final model, the risk of intentional
poisoning was lower in women than in men after adjusting for the variables of a history
of suicide attempts and the results of psychological assessment (OR=0.25, 95% CI:
0.16-0.37, p = < 0.001). The risk of suicide attempts in women suffering from underlying
psychiatric disorders (OR=1.57, 95% CI: 0.81-2.99, p = 0.188) and in women without underlying
psychiatric disease, which was not statistically significant (OR=1.07, 95% CI:
0.47-2.69, p = 0.785). Also, the results showed that the risk of psychiatric disorders in
people who had a prior suicide attempt (OR= 1.88, 95% CI: 1.05-2.25, p = <0.001) and in
women (OR=1.92, 95% CI: 1.05-2.77, p = <0.001) was statistically significant.

Conclusion:
Based on our findings, men suffering from underlying psychological disorders
and prior suicide attempts had a higher risk for intentional poisoning. On the other
hand, among people without a history of suicide attempts and without underlying psychological
disorders, the risk of intentional poisoning was higher in women. Moreover, a positive
history of suicide attempts in both genders significantly increases the risk of having a
psychological disorder. Therefore, it seems that underlying psychological disorders and a
positive history of suicide attempts render women more vulnerable to intentional poisoning
than men. Overall, it is suggested to consider screening for psychological disorders as a
preventive measure in individuals proven to have intentional poisoning and suicide attempts,
especially in men.
Tunisian Validation of The Children’s Depression Inventory-2 in
School-based Children
Authors: Ayadi Hela , Boudabous Jaweher , Kerkeni Ali , Kraiem Mayssa , Yaich Sourour , Moalla Yousr 
Published: January 2024

Background:
Clinical observations advocate for increasingly depressive disorders
in children in Tunisia. However, no studies evaluating the prevalence of depression in
Tunisian children have been published because of the lack of validated Arabic depression
scale for children.

Aim:
Thus, we aimed to validate the Children’s Depression Inventory in its second edition
(CDI-2).

Method:
The present study was conducted on a representative sample of school-based Tunisian
children in the city of Sfax. The sample was composed of 500 children aged 8– 12
years. The study took place in two phases. The first phase consisted of testing scales for
participating children. During the second phase, children with depressive symptoms, according
to the CDI-2, were invited for psychiatric interviews. Statistical evaluation included
an assessment of the CDI-2 internal consistency, test-retest reliability and concurrent
validity. Multi-trait scaling analysis was used to examine item convergent and discriminant
validity. The CDI-2 was reliable in terms of internal consistency (0.887), with item-total
score correlations ranging from 0.311 to 0.674. All items exceeded the 0.4 criterion for
convergent validity in all subscales.

Result:
The mean total score of the CDI-2 for the whole sample was 12.59 (SD=9.28).
CDI-2 and DSRS-C scores correlated 0.775. Correlations between DSRS-C scores and
CDI-2 subscales ranged from 0.66 to 0.783.

Conclusion:
We concluded that the CDI-2 Arabic version has satisfactory psychometric
properties and is reliable for use in the Tunisian pediatric population.
Acetaldehyde and Butyrate: Their Biological Effects on the Liver and the
Gut Axis
Authors: Liu Lu , Kanwal Abhinav , Singh Shailendra Pratap , Kumar Avinash 
Published: January 2024

Abstract:
The gut is the most accommodating environment in the human body for bacteria. The
microbial community there is both dense and varied. The gut microbe forms an axis with the human
liver, according to the theory of liver disease causation. The portal vein, systemic circulation,
and biliary tract all provide bidirectional connections between the liver and the intestines. The liver
secretes bile acid and a wide variety of bioactive mediators into the biliary tract and general circulation.

:
On the other hand, the portal vein carries microbial-produced endogenous compounds from the
colon to the liver, where they might disrupt liver function. Acetyl-aldehyde and butyrate are two
of the many byproducts produced by the microbiota in the human gut in response to indigestible
food. In addition, these two waste products alter liver function and play an important role in maintaining
intestinal health in humans. This paper reviews the literature on the link between butyrate
and acetyl-aldehyde production in the human gut and the organ's role in the development of liver
disease. Butyrate, acetyl-aldehyde, and liver disease all play roles in the gut-liver axis.
Advanced Therapeutic Medicinal Products in Bone and Cartilage Defects
Authors: Diaz-Solano Dylana , Sadri Bahareh , Peshkova Maria , Shpichka Anastasia , Smirnova Olga , Shams Roshanak , Timashev Peter , Vosough Massoud 
Published: January 2024

Abstract:
The number of patients with functional loss of bone and cartilage tissue has shown an increasing
trend. Insufficient or inappropriate conventional treatments applied for trauma, orthopedic
diseases, or other bone and cartilage-related disorders can lead to bone and cartilage damage. This
represents a worldwide public health issue and a significant economic burden. Advanced therapeutic
medicinal products (ATMPs) proposed promising alternative therapeutic modalities by application
of cell-based and tissue engineering approaches. Recently, several ATMPs have been developed
to promote bone and cartilage tissue regeneration. Fifteen ATMPs, two related to bone and 13
related to cartilage, have received regulatory approval and marketing authorization. However, four
ATMPs were withdrawn from the market for various reasons. However, ATMPs that are still on the
market have demonstrated positive results, their broad application faced limitations. The development
and standardization of methodologies will be a major challenge in the coming decades. Currently,
the number of ATMPs in clinical trials using mesenchymal stromal cells or chondrocytes indicates
a growing recognition that current ATMPs can be improved. Research on bone and cartilage
tissue regeneration continues to expand. Cell-based therapies are likely to be clinically supported by
the new ATMPs, innovative fabrication processes, and enhanced surgical approaches. In this study,
we highlighted the available ATMPs that have been used in bone and cartilage defects and discussed
their advantages and disadvantages in clinical applications.
Cholecalciferol Exhibits no Antibacterial Effect on Staphylococcus
aureus and Escherichia coli: An in vitro Study
Authors: Kurian Shilia Jacob , Biswas Avirup , Kulavalli Shrivathsa , Aranjani Jesil Mathew , Pattanaik Amrita , Munisamy Murali , Saravu Kavitha , Rodrigues Gabriel Sunil , Miraj Sonal Sekhar 
Published: January 2024

Background::
The pleiotropic effect of cholecalciferol (vitamin D3) has gained
significant momentum and has been explored widely.

Objectives::
The study aimed to investigate the antimicrobial effect of cholecalciferol
against S. aureus and E. coli.

Methods::
An in-vitro study was performed for the antimicrobial effect of cholecalciferol against
S. aureus and E. coli. The minimum inhibitory concentration (MIC) and minimum bactericidal
concentration (MBC) were determined following the broth microdilution method.

Results::
The MIC value of cholecalciferol against both S. aureus and E. coli was 0.312
mg/ml, and the MBC for both organisms was 1.25 mg/ml. However, we also observed a
significant antimicrobial effect in the dimethyl sulfoxide (DMSO) control at 12.5% (v/v).
Therefore, the observed antimicrobial effect may be attributed to DMSO, indicating cholecalciferol
does not directly inhibit S. aureus and E. coli.

Conclusion::
This study indicates that cholecalciferol does not directly inhibit S. aureus
and E. coli. Hence, we suggest exploring the antibacterial properties of other vitamin D
analogs, such as calcitriol or its synergetic effect with other antimicrobial agents.
Risk Identification in Perinatal Health Care Settings via Technology-Based Recruitment Methods: Comparative Study
Authors: Beatty Jessica R , Zelenak Logan , Gillon Spencer , McGoron Lucy , Goyert Gregory , Ondersma Steven J 
Published: January 2024

Background
Digital screening and intervention tools have shown promise in the identification and reduction of substance use in health care settings. However, research in this area is impeded by challenges in integrating recruitment efforts into ongoing clinical workflows or staffing multiple study clinics with full-time research assistants, as well as by the underreporting of substance use.

Objective
The aim of the study is to evaluate pragmatic methods for facilitating study recruitment in health care settings by examining recruitment rates and participant characteristics using in-person–based versus flyer approaches.

Methods
This study compared recruitment rates at a Women’s Health clinic in the Midwest under 2 different recruitment strategies: in person versus via a flyer with a QR code. We also examined the disclosure of substance use and risk screener positivity for the 2 strategies. We also obtained information about the current use of technology and willingness to use it for study participation.

Results
A greater percentage of patients recruited in person participated than those recruited via flyers (57/63, 91% vs 64/377, 17%). However, the final number recruited in each group was roughly equal (n=57 vs n=64). Additionally, participants recruited via flyers were more likely to screen positive for alcohol use risk on the Tolerance, Annoyed, Cut Down, Eye-Opener alcohol screen than those recruited at the clinic (24/64, 38% vs 11/57, 19%; χ21=4.9; P=.03). Participants recruited via flyers were also more likely to screen positive for drug use risk on the Wayne Indirect Drug Use Screener than those recruited at the clinic (20/64, 31% vs 9/57, 16%; χ21=4.0; P=.05). Furthermore, of the 121 pregnant women, 117 (96.7%) reported owning a smartphone, 111 (91.7%) had an SMS text message plan on their phone, and 94 (77.7%) reported being willing to receive SMS text messages or participate in a study if sent a link to their phone.

Conclusions
The distribution of flyers with a QR code by medical staff appears to be an efficient and cost-effective method of recruitment that also facilitates disclosure while reducing the impact on clinic workflows. This method of recruitment can be useful for data collection at multiple locations and lead to larger samples across and between health systems. Participant recruitment via technology in perinatal health care appears to facilitate disclosure, particularly when participants can learn about the research and complete screening using their own device at a place and time convenient for them. Pregnant women in an urban Midwestern hospital had access to and were comfortable using technology.
Formulasi biskuit tepung tempe biji kedawung (Parkia roxburghii G. Don) untuk pasien diabetes melitus
Authors: Triyanto Bagaskara Putra , Nugroho Teddy Wahyu , Widyastuti Nurmasari , Masruroh Zulfatul , Anjani Gemala 
Published: January 2024

Formulations of biscuits from kedawung seed tempeh flour (Parkia roxburghii G. Don) for diabetes mellitus patientsBackground: Diabetes mellitus (DM) is a metabolic disease characterized by hyperglycemia. Blood glucose can be controlled with food consumption with low glycaemic index (GI) and glycaemic load (GL) values. Kedawung seeds contain high protein and fiber and can be an alternative to low GI and GL food sources for DM patients. Objectives: This research analyzed total protein, crude fiber, glycaemic index, and glycaemic load levels from biscuits by substituting kedawung seed tempeh flour.Methods: The study was an experimental study with four treatments. The substitution of kedawung seed tempeh flour in biscuits was 0%, 10%, 30%, and 50%. Protein content was analyzed using the Kjeldahl method, and crude fiber was analyzed using the gravimetric method. Statistical analysis was done using the One Way ANOVA and Tukey posthoc test. A hedonic test on 25 semi-trained panelists was conducted to determine the best formulation, and the results were analyzed using the Kruskal Walls and Friedman post-hoc test. IAUC analyzed the glycaemic index from 10 respondents. Results: Biscuits substituting kedawung seed tempe flour affected protein content (p=0.00) and crude fiber (p=0.00). The best acceptance was biscuits with a 10% substitution of kedawung seed tempeh flour, which has a 32.28% glycemic index value and a 9.98% glycemic load. Conclusions: The biscuits substituting kedawung seed tempeh flour significantly increased protein and crude fiber content. Biscuit formulation with 10% kedawung seed tempeh flour had a low glycemic index and glycemic load.
Putins hellige krig
Authors: Horsfjord Vebjørn 
Published: January 2024

Vårt Lands tidligere sjefredaktør Helge Simonnes har skrevet Putins hellige krig, det er den første boka på norsk om den russisk-ortodokse kirkens støtte til Putins krigføring.
Helge Simonnes, the former editor-in-chief of Vårt Land, has written Putin's Holy Har (Putins hellige krig), the first book in Norwegian about the Russian Orthodox Church's support for Putin's warfare.
Homenagem: Dr. Jacques Rodineau
Authors:   al Ettifaq Club, Dammam, Saudi Arabia, Ribeiro Basil 
Published: January 2024

“O Dr. Jacques Rodineau faleceu em 13 de outubro de 2023, aos 87 anos. Partiu para outro Mundo, mas não nos abandonou. Deixou-nos a memória de belos momentos de convívio e do conforto que nos dava... Deixou-nos a tristeza da sua partida, mas deixou-nos também a certeza que partiu bem... Mas, para nós, era também um amigo e um grande mestre. Ele era o médico que eu gostaria de ser, era o médico que falava com o paciente e o examinava depois, que o ouvia e queria compreender, que o tratava e consolava.” Depoimentos de: 1.	Dr. Raul Maia e Silva 2.	Prof. Dr. João Páscoa Pinheiro, Dr. Pedro Lemos Pereira 3.	Prof. Doutor Fernando Fonseca 4.	Dr. Gonçalo Borges 5.	Dr. Henrique Jones
HUBUNGAN ANTARA PRENATAL ATTACHMENT DENGAN KEPATUHAN KONSUMSI TABLET TAMBAH DARAH PADA IBU HAMIL TRIMESTER III DI WILAYAH KERJA PUSKESMAS BATULENGER KECAMATAN SOKOBANAH KABUPATEN SAMPANG
Authors: Mursyida Rikhly Faradisy , Fithriani Zainun Wahida 
Published: January 2024

Prenatal Attachment adalah adanya suatu hubungan khusus yang terbentuk di antara ibu dan janinnya. Prenatal attachment erat kaitannya dengan kontrol kesehatan janin internal atau internal fetal health locus of control (FHLC-I). Mengkonsumsi suplemen penambah darah adalah salah satu tindakan untuk hidup sehat yang perlu dilakukan oleh ibu hamil untuk mencegah terjadinya anemia akibat kekurangan zat besi yang akan mempengaruhi kesehatan ibu dan janin. Tujuan dari peneltian ini adalah untuk menganalisis hubungan prenatal attachment dengan keteraturan minum tablet tambah darah pada ibu hamil trimester III di Wilayah Kerja Puskesmas Batulenger. Desain penelitian ini menggunakan analitik observasional dengan pendekatan cross sectional, populasi penelitian adalah semua ibu hamil trimester III (dengan usia kehamilan 28-40 minggu) atau jumlah K4 pada bulan april yang ada di Wilayah Kerja Puskesmas Batulenger dengan total 61 responden, jumlah sampel adalah 53 responden dengan menggunakan rumus Slovin dan teknik samplingnya menggunakan Purporsive Sampling. Hasil penelitian menunjukkan bahwa sebagian besar memiliki prenatal attachment yang tinggi yaitu 39 responden (73,6%), dan sebagian besar memiliki keteraturan minum tablet tambah darah yang tinggi yaitu 34 responden (64,2%). Analisis penelitian menggunakan Chi-Square menunjukkan hasil p-value α dengan nilai p value 0,001 maka H0 ditolak. Berdasarkan hasil penelitian tersebut dapat disimpulkan bahwa ada hubungan antara prenatal attachment dengan keteraturan minum tablet tambah darah pada ibu hamil trimester III di Wilayah Kerja Puskesmas Batulenger
HUBUNGAN POLA MAKAN DENGAN KADAR ASAM URAT PADA REMAJA DI PRODI AKUNTANSI FAKULTAS EKONOMI UNIVERSITAS MUHAMMADIYAH PONOROGO
Authors: Rosalina Chiara , Nurhidayat Saiful , Mas'udah Anni Fithriyatul 
Published: January 2024

Kesehatan tubuh kita sangat dipengaruhi oleh pola hidup sehat, salah satunya adalah pola makan yang sehat. Pola makan yang buruk dapat menimbulkan berbagai masalah kesehatan, salah satunya adalah penyakit asam urat atau gout arthritis. Berdasarkan hasil studi pendahuluan terhadap 35 mahasiswa di Universitas Muhammadiyah Ponorogo diketahui prevalensi tertinggi yaitu Fakultas Ekonomi dengan jumlah 4 dari 6 mahasiswa terindikasi memiliki kadar asam urat tinggi. Hasil tersebut didominasi oleh mahasiswa Prodi Akuntansi Angakatan 2020 yang gemar mengkonsumsi daging seperti korean grill food, bakaran mie, maupun seblak. Selain itu, mahasiswa juga kurang berolahraga. Hal tersebut menyebabkan mereka cenderung menderita kelebihan berat badan. Sehingga, penelitian ini bertujuan untuk mengetahui hubungan pola makan dengan kadar asam urat pada remaja di Prodi Akuntansi Universitas Muhammadiyah Ponorogo. Penelitian ini menggunakan desain cross-sectional. Populasi dari Prodi Akuntansi Angkatan 2020 Universitas Muhammadiyah Ponorogo sebesar 60 mahasiswa dengan sampel 40 mahasiswa. Variabel independen pola makan dengan instrumen penelitian berupa kuesioner dan variabel dependen kadar asam urat dengan instrumen uric acidmeter. Analisis data dilakukan dengan uji chi-square.Hasil penelitian dari 40 responden diketahui bahwa pada kategori pola makan, sebesar 60,0% responden memiliki pola makan yang baik sebesar 24 mahasiswa sedangkan 40,0% responden memiliki pola makan sebesar 16 mahasiswa. Pada kategori kadar asam urat, sebesar 67,5% termasuk dalam kategori normal sebesar 27 mahasiswa sedangkan 32,5% responden termasuk dalam kategori asam urat tinggi dengan prevalensi 13 mahasiswa. Berdasarkan chi-square test diperoleh pvalue yaitu 0,002 0,05 sehingga H0 ditolak yaitu ada hubungan antara pola makan dengan kadar asam urat pada remaja di Prodi Akuntansi Universitas Muhammadiyah Ponorogo. Dari penelitian ini diharapkan bagi remaja untuk memperbaiki dan menjaga polam makan, mengkonsumsi makanan yang rendah purin sehingga terhindar dari penyakit asam urat. Bagi peneliti selanjutnya diharapkan mampu menambah variabel yang mempengaruhi pola makan dan asam urat.
The Concepts and Practice of Statistics: Part 1 — The Basics
Authors: McLean Alan L. 
Published: January 2024

Abstract
Statistics is used in a great deal of research and in the literature. This is the first of a series of articles on the basic concepts of statistics, and how they are applied in practice. The articles are written to help clinicians read the literature with understanding; to help researchers use statistics effectively, and to help them take advantage of statistical consultants to get maximum benefit from their research.