bluuebunny/crossref_metadata_2025_split huggingface dataset:
Hypothyroidism and sinus dysfunction associated with lithium-paliperidone combination therapy for bipolar disorder with psychotic symptoms: a case report
Authors: Wei Wenjian , Yang Yonglan , Wang Haifeng , Yang Yunbin , Liu Jizhou , Li Jinfeng 
Published: February 2024

Background and aimLithium is considered to be the first-line treatment for bipolar disorder, and paliperidone was approved for the treatment of schizophrenia and acute bipolar manic/mixed episodes. However, both agents have been associated with thyroid dysfunction and cardiovascular adverse effects like subclinical hypothyroidism, bradycardia, and sinus arrest, even at therapeutic doses.Case presentationHere, we reported a case of a 17-year-old Han Chinese female who developed symptomatic hypothyroidism, sinus bradycardia, and sinus arrest while being treated with lithium and paliperidone for bipolar disorder with psychotic features including auditory hallucinations. Her workup suggested that these adverse effects might be related to the combined lithium and paliperidone treatment, although other causes could not be ruled out. After discontinuing both medications, her thyroid function and heart rhythm normalized over 20 days.ConclusionTo our knowledge, hypothyroidism, sinus bradycardia, and sinus arrest associated with the combined use of lithium and paliperidone had not been reported previously. Further research is warranted to elucidate the potential risks and benefits of this combination therapy for bipolar disorder with psychotic symptoms.
Self-managing symptoms of Long COVID: an education and strategies research protocol
Authors: Rybkina Julia , Jacob Nithin , Colella Brenda , Gold David , Stewart Donna E. , Ruttan Lesley A. , Meusel Liesel-Ann C. , McAndrews Mary P. , Abbey Susan , Green Robin 
Published: February 2024

Post-acute sequelae of SARS-COV-2 (PASC) is growing in prevalence, and involves symptoms originating from the central neurological, cardiovascular, respiratory, gastrointestinal, autonomic nervous, or immune systems. There are non-specific symptoms such as fatigue, headaches, and brain fog, which cannot be ascribed to a single system. PASC places a notable strain on our healthcare system, which is already laden with a large number of acute-COVID-19 patients. Furthermore, it impedes social, academic and vocational functioning, and impacts family life, relationships, and work/financial life. The treatment for PASC needs to target this non-specific etiology and wide-ranging sequelae. In conditions similar to PASC, such as “chemo brain,” and prolonged symptoms of concussion, the non-specific symptoms have shown to be effectively managed through education and strategies for self-management and Mindfulness interventions. However, such interventions have yet to be empirically evaluated in PASC to our knowledge. In response to this gap, we have developed a virtual education intervention synthesized by psychiatrists and clinical psychologists for the current study. We will undertake a two-phase randomized controlled trial to determine the feasibility (Phase 1; N = 90) and efficacy (Phase 2; sample sized based on phase 1 results) of the novel 8 week Education and Self-Management Strategies group compared to a mindfulness skills program, both delivered virtually. Main outcomes include confidence/ability to self-manage symptoms, quality of life, and healthcare utilization. This study stands to mitigate the deleterious intrusiveness of symptoms on everyday life in patients with PASC, and may also help to reduce the impact of PASC on the healthcare system.Clinical trial registration:https://classic.clinicaltrials.gov/ct2/show/NCT05268523; identifier NCT05268523.
Willingness to accept monkeypox vaccine and its correlates among men who have sex with men in Southern China: a web-based online cross-sectional study
Authors: Huang Xinju , Lin Zhifeng , Qin Jiao , Yu Dee , Zhang Fei , Fang Ganggang , Chen Xi , He Jinfeng , Cen Ping , Li Mu , Zhang Rongjing , Luo Tong , Jiang Junjun , An Sanqi , Liang Hao , Ye Li , Liang Bingyu 
Published: February 2024

BackgroundThe May 2022 global outbreak of monkeypox (MPX) poses a threat to the health of men who have sex with men. However, there is limited data on the willingness of MSM to receive monkeypox vaccination in Southern China. This study aimed to assess the knowledge of MPX, concerns regarding MPX, and willingness to receive monkeypox vaccination, as well as their correlates, among MSM in China.MethodsWe conducted a Web-based online survey of MSM in Southern China from August to September 2022. Data were collected on the socio-demographic characteristics, knowledge, worries, concerns regarding MPX and willingness to receive monkeypox vaccination. Multivariate logistic regression was employed to explore the factors associated with willingness to receive monkeypox vaccination.ResultsA total of 1903 participants completed the survey. Among them, approximately 69.9% reported being aware of MPX awareness, 94.1% of the participants supported the promotion of monkeypox vaccination. The majority of participants (91.4%) expressed their willingness to receive monkeypox vaccination. Participants who considered monkeypox vaccination safe [adjusted odds ratio (aOR) = 4.82, 95% CI: 1.35–17.18], agreed on the necessity of government promotion of monkeypox vaccination in China (aOR = 6.03, 95% CI: 1.07–33.93), believed in prioritizing monkeypox vaccination for MSM (aOR = 5.01, 95% CI: 1.10–22.71), and had friends or sexual partners who had already received the monkeypox or smallpox vaccination (aOR = 10.37, 95% CI: 2.11–50.99) are more likely to be vaccinated. Conversely, married individuals (aOR = 0.13, 95% CI: 0.03–0.47), those engaging in anal sex 4–6 times per week in the past 3 months (aOR = 0.26, 95% CI: 0.09–0.77) expressed hesitancy toward monkeypox vaccination.ConclusionThere was a high willingness to receive monkeypox vaccination among MSM in China. The hesitancy toward the monkeypox vaccine can be effectively mitigated by addressing concerns about its safety and potential adverse reactions. Moreover, increasing acceptance of the monkeypox vaccination among MSM and their peers is crucial, as social influence significantly impacts vaccine attitudes and behaviors.
Use of immunology in news and YouTube videos in the context of COVID-19: politicisation and information bubbles
Authors: George Rachel Surrage , Goodey Hannah , Russo Maria Antonietta , Tula Rovena , Ghezzi Pietro 
Published: February 2024

BackgroundThe COVID-19 pandemic propelled immunology into global news and social media, resulting in the potential for misinterpreting and misusing complex scientific concepts.ObjectiveTo study the extent to which immunology is discussed in news articles and YouTube videos in English and Italian, and if related scientific concepts are used to support specific political or ideological narratives in the context of COVID-19.MethodsIn English and Italian we searched the period 11/09/2019 to 11/09/2022 on YouTube, using the software Mozdeh, for videos mentioning COVID-19 and one of nine immunological concepts: antibody-dependent enhancement, anergy, cytokine storm, herd immunity, hygiene hypothesis, immunity debt, original antigenic sin, oxidative stress and viral interference. We repeated this using MediaCloud for news articles.Four samples of 200 articles/videos were obtained from the randomised data gathered and analysed for mentions of concepts, stance on vaccines, masks, lockdown, social distancing, and political signifiers.ResultsVaccine-negative information was higher in videos than news (8-fold in English, 6-fold in Italian) and higher in Italian than English (4-fold in news, 3-fold in videos). We also observed the existence of information bubbles, where a negative stance towards one intervention was associated with a negative stance to other linked ideas. Some immunological concepts (immunity debt, viral interference, anergy and original antigenic sin) were associated with anti-vaccine or anti-NPI (non-pharmacological intervention) views. Videos in English mentioned politics more frequently than those in Italian and, in all media and languages, politics was more frequently mentioned in anti-guidelines and anti-vaccine media by a factor of 3 in video and of 3–5 in news.ConclusionThere is evidence that some immunological concepts are used to provide credibility to specific narratives and ideological views. The existence of information bubbles supports the concept of the “rabbit hole” effect, where interest in unconventional views/media leads to ever more extreme algorithmic recommendations.
Experiences of childhood, intimate partner, non-partner, and hate crime-related violence among a sample of people living with HIV in the epicenter of the U.S. HIV epidemic
Authors: Sales Jessica M. , Anderson Katherine M. , Livingston Melvin D. , Garbarino Sophia , Hadera Selaem , Rose Eve S. , Carlson Madelyn S. , Kalokhe Ameeta S. 
Published: February 2024

IntroductionExperiences of violence among people living with HIV (PLWH) are thought to be highly prevalent but remain inadequately captured. As a first step toward acceptable, trauma informed practices that improve engagement and retention in care for PLWH, we must acquire more comprehensive understanding of violence experiences. We examined experiences of various forms of lifetime violence: adverse childhood experiences (ACES), intimate partner violence (IPV), non-partner violence (NPV), and hate crimes among diverse sample of PLWH in Atlanta, Georgia.MethodsCross sectional data collected from in- and out-of-care PLWH (N = 285) receiving care/support from Ryan White Clinics (RWCs), AIDS Service Organizations (ASOs), or large safety-net hospital, February 2021–December 2022. As part of larger study, participants completed interviewer-administered survey and reported on experiences of violence, both lifetime and past year. Participant characteristics and select HIV-related variables were collected to further describe the sample. Univariate and bivariate analyses assessed participant characteristics across types of violence.ResultsHigh prevalence of past violence experiences across all types (ACES: 100%, IPV: 88.7%, NPV: 97.5%, lifetime hate crimes 93.2%). People assigned male at birth who identified as men experienced more violence than women, with exception of non-partner forced sex. Participants identifying as gay men were more likely to have experienced violence.ConclusionAmong our sample of PLWH at the epicenter of the United States HIV epidemic, histories of interpersonal and community violence are common. Findings emphasize need for RWCs, ASOs, and hospital systems to be universally trained in trauma-informed approaches and have integrated onsite mental health and social support services.
Association between blood ethylene oxide levels and periodontitis risk: a population-based study
Authors: Liu Yixuan , Liu Nuozhou , Xiong Wei , Wang Ruiyu 
Published: February 2024

BackgroundThe etiopathogenesis of periodontitis is closely associated with environmental conditions. However, the relationship between ethylene oxide exposure and periodontitis risk remains unclear.MethodsWe selected qualified participants from National Health and Nutrition Examination Survey (NHANES) 2013–2014. Periodontitis was identified according to the criteria of the Community Periodontal Index (CPI), Centers for Disease Control and Prevention (CDC)/American Academy of Periodontology (AAP) definition. Ethylene oxide exposure was quantified by hemoglobin adducts of ethylene oxide (HbEO) levels. Log2-transformation was used to normalize HbEO levels. We designed three logistic regression models to explore potential relationship between HbEO and periodontitis. Restricted cubic spline (RCS) and subgroup analysis were also conducted with all covariates adjusted. We performed multivariable linear regression to appraise the association between the risk of periodontitis and different indicators of inflammation, including white blood cells, neutrophils, lymphocytes, and monocytes. Mediation analysis was subsequently performed to examine whether ethylene oxide exposure contributed to periodontitis development through systemic body inflammation.ResultsA total of 1,065 participants aged more than 30 were incorporated in this study. We identified that participants with higher HbEO levels showed increased risk of periodontitis after adjusting for all covariates (OR = 1.49, 95% CI: 1.14, 1.95, p = 0.0014). The results of subgroup analysis remained stable. The restricted cubic spline (RCS) curve also revealed a non-linear correlation between log2-transformed HbEO levels with the risk of periodontitis (p for nonlinear &lt; 0.001). Mediation analysis indicated that HbEO level was significantly associated with four inflammatory mediators, with the mediated proportions of 14.44% (p &lt; 0.001) for white blood cell, 9.62% (p &lt; 0.001) for neutrophil, 6.17% (p = 0.006) for lymphocyte, and 6.72% (p &lt; 0.001) for monocyte.ConclusionParticipants with higher ethylene oxide exposure showed higher risk of periodontitis, which was partially mediated by systemic body inflammation. More well-designed longitudinal studies should be carried out to validate this relationship.
Técnicas de Impresión 3D Para Pequeñas y Medianas Empresas de Países en Desarrollo
Authors: Pérez Baltar Ana Belén , Bracho Rodríguez Alina María , Bracho Rodríguez Amanda Isabel , Ortega Arana Junior Anthony 
Published: February 2024

Cada día la tecnología obliga a ir innovando en los procesos de producción ofreciendo diferentes metodologías de fabricación aplicables en infinitas oportunidades de negocios, en la Industria 4.0, este término involucra la incorporación de tecnologías digitales, relacionadas con la conexión a internet en los procesos de producción, y en ésta, sobresale la Manufactura Aditiva, esta reúne tecnologías basadas en la fabricación de objetos simétricos por medio de la adición de material entre ellas la impresión 3D. Tomando como referencia lo antes mencionado, este trabajo estará enfocado en identificar las organizaciones llámesele a éstas Pymes que han visto la forma de reconducir o de crear nuevas líneas de producción utilizando manufactura aditiva (Impresión 3D) en Latinoamérica y principalmente Ecuador. La metodología empleada en la realización del estudio sigue la aproximación conocida como "Desk Research". Esta metodología implica un proceso de búsqueda y selección de material documental para generar conocimiento a partir de la evidencia de investigaciones previas. Aunque en Ecuador hay varias empresas dedicadas a la impresión 3D, la tecnología como tal no está explotado a fondo, en la actualidad Ecuador esta fomenta el aprendizaje sobre la Industria 4.0, sin embargo, todo apunta que no es suficiente para estar a la línea de otros países de Latinoamérica, por ende, es necesario fortalecer la cultura tecnología desde lo gubernamental, la academia y el sector económico.
Kidney Failure Events, Cardiovascular Disease Events, and All-Cause Mortality in Patients with IgA Nephropathy in a Real-World Database
Authors: Lerma Edgar V. , Thakker Kamlesh M. , Bensink Mark E. , Lieblich Richard , Bunke C. Martin , Gong Wu , Rava Andrew R. , Wang Kaijun , Amari Diana T. , Oliveri David , Murphy Michael V. , Cork David M.W. , Velez Juan Carlos Q. 
Published: February 2024

Key Points

In our US real-world cohort study of patients with IgA nephropathy, elevated proteinuria and progression to kidney failure (KF) were associated with a higher risk of cardiovascular disease/mortality events.Elevated pre-KF proteinuria was also associated with progression to KF/mortality events.Incremental costs associated with CKD stage, nephrotic syndrome, and cardiovascular disease events and of these events were high.

Background
IgA nephropathy (IgAN)–associated glomerular injury leads to proteinuria, hematuria, and progressive loss of GFR, with progression to kidney failure (KF). This retrospective study evaluated the prognostic effects of proteinuria and progression to KF on cardiovascular disease (CVD)/mortality events and KF/mortality events in the United States.

Methods
We conducted a noninterventional, retrospective cohort study in adult patients with IgAN using Optum's deidentified Market Clarity Data (January 1, 2007, to March 31, 2021). Adult (age ≥18 years) patients with at least two signs, disease, symptoms natural language processing term entries for IgAN, within 180 and ≥30 days apart within the identification period were included. Outcomes were assessed by time-dependent proteinuria (≥1 versus <1 g/d) and KF status (pre versus post). Descriptive statistics were used for categorical and continuous variables. Multivariable Cox proportional hazard models with time-dependent predictors were used to estimate differences across groups.

Results
Patients with pre-KF status and proteinuria ≥1 g/d were more likely to have a CVD/mortality event during follow-up (adjusted hazard ratio [HR; 95% confidence interval (CI)]: 1.80 [1.12 to 2.89]; P < 0.001) or a KF/mortality event (adjusted HR [95% CI]: 2.10 [1.73 to 2.56]; P < 0.001). Patients with post-KF status were more likely to have a CVD/mortality event during follow-up (adjusted HR [95% CI]: 3.28 [2.82 to 3.81]; P < 0.001).

Conclusions
Elevated proteinuria and progression to KF were associated with a higher risk of CVD/mortality events. Elevated pre-KF proteinuria was also associated with progression to KF/mortality events. On the basis of our real-world retrospective database analysis, we hypothesize that novel IgAN therapies that reduce proteinuria and slow the rate of progression to KF have the potential to reduce CVD risk, improve kidney outcomes, and prolong/increase overall survival.
Multidrug-Resistant Tuberculosis in Belarus: Incidence, Development Risks, Prognosis
Authors: Скрягина Е.М. , Калечиц О.М. , Журкин Д.М. , Глинская Т.Н. , Дюсьмикеева М.И. , Климук Д.А. , Сапрыкина Ж.А. , Ветушко Д.А. , Бобрукевич Е.Л. , Белько А.Ф. 
Published: February 2024

Представлены результаты анализа эпидемиологических данных распространенности множественно лекарственно-устойчивого туберкулеза в Беларуси за 2013–2022 гг. и прогноз заболеваемости на 2023–2025 гг. На фоне ежегодного снижения общей заболеваемости туберкулезом с 47,6 до 18,2 на 100 тыс. населения удельный вес МЛУ-ТБ остается высоким как среди впервые диагностированных случаев (35,7%), так и среди ранее леченных пациентов (60,0%). Установлен риск развития и распространенности МЛУ-ТБ при наличии у пациентов с туберкулезом коморбидных заболеваний. Показана целесообразность лечения пациентов с МЛУ-ТБ в сочетании с ВИЧ-инфекцией и хроническим вирусным гепатитом С в специализированных центрах туберкулеза. Прогнозные данные свидетельствуют о дальнейшем улучшении эпидемической ситуации с туберкулезом и МЛУ-ТБ в ближайшие 3 года: общая заболеваемость туберкулезом составит от 16,7 до 13,9 на 100 тыс. населения, МЛУ-ТБ – от 6,4 до 5,6 на 100 тыс. населения.
The results of an analysis of epidemiological data on the prevalence of multidrug-resistant tuberculosis in Belarus for 2013–2022 are presented. and incidence forecast for 2023–2025. Against the background of an annual decrease in the overall incidence of tuberculosis from 47.6 to 18.2 per 100 thousand population, the proportion of MDR-TB remains high, both among newly diagnosed cases (35.7%) and among previously treated patients (60.0%). The risk of development and prevalence of MDR-TB has been established in the presence of comorbid diseases in patients with tuberculosis. The feasibility of treating patients with MDR-TB in combination with HIV infection and chronic viral hepatitis C in specialized tuberculosis centers has been demonstrated. Forecast data indicate a further improvement in the epidemic situation with tuberculosis and MDR-TB in the next 3 years: the overall incidence of tuberculosis will be from 16.7 to 13.9 per 100 thousand population, MDR-TB – from 6.4 to 5.6 per 100 thousand population.
Assessment of Complications in Patients Diagnosed with COVID-19 According to the Degree of Severity
Authors: Мамедова Х.Г. 
Published: February 2024

Течение инфекции COVID-19 в основном классифицируется как легкое, среднетяжелое, тяжелое и критическое (крайне тяжелое). Были исследованы параметры периферической крови, такие как общее количество лейкоцитов, лимфоцитов, нейтрофилов, а также другие биохимические параметры крови и факторы свертывания, которые связаны с тяжестью инфекции COVID-19. Выявлены биомаркеры, предсказывающие тяжесть и исход пациентов с COVID-19. Наши результаты показывают, что тяжелая лимфопения и повышенный уровень С-реактивного белка (118,41 мг/л) связаны с тяжестью гипоксемии и прогнозируемой госпитальной смертностью. Кроме того, изменения количества лейкоцитов в течение первых 4 дней после госпитализации были в высокой степени связаны с осложнениями (pU<0,001).
The coronavirus infection 2019 (SARS-CoV-2, COVID-19) is mainly classified as mild, moderate and severe and critical. Peripheral blood parameters such as total leukocyte count, lymphocytes, neutrophils, as well as other blood biochemical parameters and coagulation factors were investigated to be associated with the severity of the COVID-19 infection. In our presentation, the identification of biomarkers that predict the severity and outcome of patients with COVID-19 was very helpful. Our results show that severe lymphopenia and elevated C-reactive protein (118.41 mg/L) are associated with hypoxemia severity and predicted hospital mortality. In addition, changes in leukocyte count during the first 4 days after hospitalization were highly associated with complications, pU<0.001.
Pengaruh Pengetahuan Keuangan dan Locus of Control Terhadap Perilaku Pengelolaan Keuangan Mahasiswa di Universitas Muhammadiyah Riau
Authors: Ayu Novia Nella , Berlianti Nadya , Rahmi Anasril Aulia , Rodiah Siti 
Published: February 2024

Tujuan penelitian ini untuk menganalisis pengaruh pengetahuan keuangan dan locus of control terhadap perilaku pengelolaan keuangan di Universitas Muhammadiyah Riau. Saat ini mahasiswa sudah mempelajari bagaimana pengetahuan keuangan dan locus of control yang sudah dipelajari dan pada penilitian ini apakah variable mempengaruhi perilaku keuangan mahasiswa tersebut. Penelitian ini menggunakan metode kuantitatif dan Teknik yang digunakan dalam pengambilan sampel adalah random sampling. Uji coba instrumen dianalisis menggunakan uji validitas dan uji reliabilitas dan menggunaka IBM SPSS Statistic 20, sebelum menguji hipotesis, terlebih dahulu dilakukan uji instrumen, kemudai melaksanakan uji asumsi klasik yaitu uji normalitas, uji multikolinieritas, dan uji heteroskedastisitas Dari hasil yang telah dilakukan pada pengetahuan keuangan dan locus of control terhadap perilaku pengelolaan keuangan mahasiswa menjunjukkan hasil signifikan positif.
Dampak Pengembangan Komoditi Nilam terhadap Kesejahteraan Masyarakat Kabupaten Nagan Raya
Authors: Hernisa Frici Manza , Risma Okta Rabiana 
Published: February 2024

In this study, the purpose of the research was to see the development anda development of patchouli on the welfare of the commonity. This research was conducted in Ujong Blang Village and Blang Baro Rambong Village, Beutong District, Nagan Raya Regency. The problem is with the develpoment of patchuli , it is hoped that is can improve the commodity’s economy because there is still a large area of abandonedland with fertile soil being one of the very good potentials for patchuoli. In this study, researchers used qualitative methods, which collected data through primary and secondary data. The method used in descriptive method. Secondary data was obtained from the regional development planning agency and primary data was obtained by direct interviews with patchuoli farmers. The respondent in this study consisted of internal. Parties, namely the Village head of Ujong Blang Village and Blang Baro Rambong Village. External parties, namery the head of the economy development planning division of the regional development planning agency of Nagan Raya Regency. Basd of the result of research on the development of the patchuoli commodity on the welfare of the commodity, the benefits can a better standard of living.