bluuebunny/crossref_metadata_2025_split huggingface dataset:
An unusual presentation of ossified spinal meningioma: case report and literature review
Authors: Xu Wen-Bin , Sun Nai-Kun , Cai Di-Xin , Chen Ding-Qiang , Niu Yuan , Jia Fang , Lin Guang-Xun , Rui Gang 
Published: September 2023

BackgroundSpinal meningioma is a common intraspinal tumor, which mainly occurs in the thoracic spine. Ossified meningioma (OSM) is an extremely rare histological variant. Our article reports a rare patient with dorsal complete OSM and reviews this subject.Case presentationA 68-year-old woman presented with a one-year history of progressive weakness in both lower limbs with gait disturbance. Physical examination revealed hypoesthesia with a sensory level below T10. Babinski and pathological signs on both sides were weakly positive. Magnetic resonance imaging (MRI) showed a mass at the T10 to T11 level causing severe compression of the spinal cord. Computed tomography (CT) showed complete ossification of the mass. 18F-Fluoro-deoxy-glucose positron emission tomography CT (18F-FDG PET/CT) scan combined with MRI revealed that the mass was an intradural extramedullary high-density ossified nodule. The patient underwent a gross total resection of the mass and pathologic examination indicated that the mass was a meningioma with diffused psammomatous bodies.ConclusionWe identified a rare case of dorsal complete OSM occurring in a 68-year-old woman. After complete surgical resection, although there were complications such as cerebral fluid leakage and fever, the patient finally recovered with a satisfactory result.
Optimization of the dosage regimen of zoledronic acid with a kinetic-pharmacodynamic model and exposure-response analysis
Authors: Wang Huan , Liu Qi , Jiang Muhan , Song Chunli , Liu Dongyang 
Published: September 2023

Purpose: In order to support the dose optimization of zoledronic acid, the kinetic-pharmacodynamic model and exposure-response analysis were used to describe the changes in bone mineral density in different doses of zoledronic acid and establish the relationship between dose and acute phase reaction.Methods: Data were extracted from literature in accessible public databases. The kinetic-pharmacodynamic model was developed based on the above data using the NONMEM package to estimate parameters describing the relationship between the dose of zoledronic acid and bone mineral density. Exposure-response analysis was developed to establish the relationship between dose and acute phase reaction. Model evaluation was performed using goodness-of-fit, coefficient of variation (CV%). And sensitivity analyses were performed to assess the necessity of related parameters. Then the established model was used to simulate the changes of bone mineral density under different administration regimens, and the literature data was verified.Results: The kinetic-pharmacodynamic model successfully described zoledronic acid dose and change of bone mineral density in osteoporosis patients, with coefficient of variation of most less than 71.5%. The exposure-response analysis showed the incidence of acute phase reaction is dose-dependent. The bone mineral density was simulated based on the developed kinetic-pharmacodynamic model. And the simulated change of bone mineral density and the incidence of acute phase reaction could be helpful to propose a dosage regimen.Conclusion: Overall, the kinetic-pharmacodynamic model described changes of bone mineral density in different doses of zoledronic acid in vivo. And, the model and the exposure-response analysis also showed to provide the assessment of dose-response relationship for zoledronic acid.
Methylene blue in anticancer photodynamic therapy: systematic review of preclinical studies
Authors: Taldaev Amir , Terekhov Roman , Nikitin Ilya , Melnik Elizaveta , Kuzina Vera , Klochko Mikhail , Reshetov Igor , Shiryaev Artem , Loschenov Victor , Ramenskaya Galina 
Published: September 2023

Background: Methylene blue has a long history of clinical application. Thanks to phenothiazine chromophore, it has potential in photodynamic anticancer therapy. In spite of the growing body of literature that has evaluated the action of this dye on different types of cancer, the systematic understanding of this problem is still lacking. Therefore, this systematic review was performed to study the efficacy of methylene blue in photodynamic anticancer therapy.Methods: This systematic review was carried out in accordance with the PRISMA guidelines, and the study protocol was registered in PROSPERO (CRD42022368738). Articles for the systematic review were identified through the PubMed database. SYRCLE’s risk of bias tool was used to assess the studies. The results of systematic analysis are presented as narrative synthesis.Results: Ten studies met the inclusion criteria and these full texts were reviewed. In the selected articles, the dosage of dye infusion ranged from 0.04 to 24.12 mg/kg. The effectiveness of photodynamic therapy with methylene blue against different types of cancer was confirmed by a decrease in tumor sizes in seven articles.Conclusion: The results of the systematic review support the suggestions that photodynamic therapy with methylene blue helps against different types of cancer, including colorectal tumor, carcinoma, and melanoma. In cases of nanopharmaceutics use, a considerable increase of anticancer therapy effectiveness was observed. The further research into methylene blue in photodynamic anticancer therapy is needed.Systematic Review Registration: (https://www.crd.york.ac.uk/prospero/display_record.php?RecordID=368738), identifier (CRD42022368738).
Effects of high-intensity interval training on lean mass, strength, and power of the lower limbs in healthy old and young people
Authors: Caparrós-Manosalva Cristian , Garrido-Muñoz Nicolás , Alvear-Constanzo Bastián , Sanzana-Laurié Sofía , Artigas-Arias Macarena , Alegría-Molina Andrea , Vidal-Seguel Nicolás , Espinoza-Araneda Jessica , Huard Nolberto , Pagnussat Aline Souza , Sapunar Jorge , Salazar Luis A. , Marzuca-Nassr Gabriel Nasri 
Published: September 2023

Introduction: Whether high-intensity interval training (HIIT) can improve lean mass, strength, and power of the lower limbs in young and older people is still under discussion. This study aimed to determine the effect of HIIT on lean mass, maximal strength, rate of force development (RFD), and muscle power of both lower limbs in healthy young and older adults. Secondarily, to compare the effects of HIIT between dominant vs. non-dominant lower limbs of each group.Materials and methods: Healthy older (n = 9; 66 ± 6 years; BMI 27.1 ± 3.1 kg m−2) and young (n = 9; 21 ± 1 years; BMI 26.2 ± 2.8 kg m−2) men underwent 12 weeks of HIIT (3x/week) on a stationary bicycle. The evaluations were made before and after the HIIT program by dual energy X-ray absorptiometry (DEXA), anthropometry, force transducer and, Sit-to-Stand test. The outcomes analyzed were limb lean mass, thigh circumference, maximal voluntary isometric strength, RFD (Time intervals: 0–50, 50–100, 100–200, and 0–200 ms), and muscle power in both lower limbs.Results: After 12 weeks of HIIT, non-dominant limb (NDL) showed increase in limb lean mass (p &lt; 0.05) but without interaction (time*group). HIIT showed a gain in absolute maximal strength and also when adjusted for thigh circumference in the dominant lower limb (DL) in both groups. The RFD0–200 ms showed differences between groups but without interaction. The RFD0–50 ms of the NDL showed post-training improvements (p &lt; 0.05) in both groups. Only the older group showed differences between DL vs. NDL in most of the RFD obtained post-intervention. In addition, post-HIIT muscle power gain was observed in both groups (p &lt; 0.05), but mainly in older adults.Conclusion: HIIT promotes increases in lean mass, maximal strength, early RFD, and lower limb muscle power in healthy older and young individuals. The differences shown between the DL and the NDL must be analyzed in future studies.
Ageing, the digital and everyday life during and since the Covid-19 pandemic
Authors: Martin Wendy , Collett George , Bell Chris , Prescott Amy 
Published: September 2023

IntroductionDuring and since the Covid-19 pandemic there has been an intensified integration of digital technologies into the everyday lives of older people. We do, however, know little about the ways in which older people incorporate digital technologies and communications into their daily lives and their own meanings, embodiment and experiences of the digital during and since the Covid-19 pandemic.MethodThe aim of our research was to explore the use of digital devices during and since the Covid-19 pandemic and to identify facilitators and barriers to incorporating digital devices into everyday life. The research involved a series of online focus groups with people aged between 63 and 86 years living in the United Kingdom and were conducted in 2022. Each focus group lasted around 90 min and data was audio-recorded and transcribed. The data was analysed thematically.ResultsFrom the analysis, three interconnecting whilst analytically distinct themes around the meaning and experiences of using digital devices in everyday life during and since the pandemic, are thematically presented as: (1) Incorporating the digital into everyday life; (2) Social and digital connectivity; and (3) Challenges and limitations of the digital in everyday life.DiscussionThe research has provided insights into the way digital devices were used by older people during and since the Covid-19 pandemic. In particular, we highlight the increasing importance of digital connectivity and the ways in which older people actively engage (and resist) technologies of communication in their daily lives; and the significance of embodied co-presence and the immediacy of shared space and/or time is highlighted.
Prevalence of mental disorders and psychological trauma among conflict- affected population in Somalia: a cross-sectional study
Authors: Salad Abdulwahab M , Malik SK Md Mamunur Rahman , Ndithia James Mwangi , Noor Zeynab , Madeo Marina , Ibrahim Mohamed 
Published: September 2023

BackgroundDespite the longstanding psychosocial impact of the interactable conflict in Somalia for the last 30 years, there is lack of epidemiological studies of mental health conditions, especially at the population level.ObjectivesThe aim of this study is to fill the epidemiological gap and provide population based data on mental health conditions in the South-Central region of Somalia. The specific objectives were: (1) To determine the epidemiological patterns of mental disorders in three sites; Baidoa, Dolow and Kismayo, (2) Understand the socio-demographic characteristics associated with mental health conditions in the study sites, and (3) To assess the correlates between psychological trauma and the mental wellbeing of the population.MethodsThis was a cross-sectional study of 713 respondents recruited from the three sites namely Dolow, Baidoa and Kismayo. Data on sociodemographic characteristics and mental disorders were collected using the MINI and sociodemographic questionnaire. Basic descriptive statistics were used to summarize sociodemographic characteristics. Univariable and multivariable logistic regressions were used to examine factors associated with common mental disorders. Statistical significance was considered at a value of p &lt;0.05.ResultsParticipants’ mean age was 32.6 (±10.7) years. More than half (58.5%) of the respondents were male. The overall prevalence of common mental disorders was 557 (78.1%) with panic disorder (39.3%), generalized anxiety disorders (34.9%), major depressive episode current (32.1) and PTSD (29.9%). According to the multivariable logistic regression analysis, being male AOR = 1.74 (95%CI = 1.25, 2.42), having a family size of more than 10 members AOR =1.37 (95% CI = 1.00, 1.89), being unemployed AOR = 1.90 (95%CI = 1.18, 3.06), experienced starvation AOR =3.46 (95%CI = 2.23, 5.37), khat use AOR = 5.87 (955 CI, 1.75–19.65), were identified as predicting factors for the common mental disorders among the study participants.ConclusionThere is a high prevalence of mental disorders with anxiety disorders being the commonest. Findings reflect earlier studies that showed higher rates in conflict and post-conflict settings. It also aligns with past studies in Somalia. As such, there is an urgent need to integrate mental health and psychosocial support within the primary healthcare and other service sectors such as education considering the vast majority of the population are young.
Predicting osteoporosis preventive behaviors in middle-aged and older urban Shanghai residents: a health belief model-based path analysis in a multi-center population study
Authors: Wang Yichen , Li Chenrui , Chang Ruijie , Qiao Yongxia , Cai Yong , Shen Tian 
Published: September 2023

BackgroundOsteoporosis represents a significant health concern as a widespread metabolic bone condition. In this study, we aim to utilize path analysis to examine the intricate relationships among demographic information, Health Belief Model (HBM) constructs and osteoporosis preventive behavior among Shanghai residents over 40 years of age.MethodsA multi-center population study was conducted in 20 volunteer communities in Shanghai, China. Out of the 2,000 participants who volunteered, 1,903 completed the field survey.Results56.0% of participants were females. Their mean age was 63.64 ± 10.30 years. The self-efficacy score among females (42.27 ± 15.82) was also significantly higher than that among males (40.68 ± 15.20). in the pathway analysis. In the path analysis preventive behaviors were significantly predicted by education (β = 0.082, p &lt; 0.001), knowledge (β = 0.132, p &lt; 0.001) and self-efficacy (β = 0.392, p &lt; 0.001).ConclusionsThis study highlights the importance of gender, education, knowledge and self-efficacy in promoting OP preventive behaviors using the Health Belief Model. The findings emphasize the need for tailored interventions to address the specific needs of different demographic groups.
Evaluation of finger cartilage composition in recreational climbers with 7 Tesla T2 mapping magnetic resonance imaging
Authors: Bayer Thomas , Brockhoff Marie-Jo , Nagel Armin M. , Adler Werner , Lutter Christoph , Janka Rolf , Heiss Rafael , Uder Michael , Roemer Frank W. 
Published: September 2023

PurposeSport climbing may lead to tissue adaptation including finger cartilage before apparent surface damage is detectable. The main aim was to assess finger cartilage composition with T2 mapping in young, active climbers and to compare the results to a non-climbers' collective. A secondary aim was to compare whether differences in cartilage T2 times are observed between older vs. younger volunteers.Methods and materials7 Tesla MRI of the fingers Dig.2–4 was performed using a multi-echo spin echo sequence. Manual segmentation of 3 ROIs at the metacarpal heads, 1 ROI at the base phalanx and 1 ROI at the proximal interphalangeal joint was performed. Included were 13 volunteers without history of trauma who are regularly performing climbing activities as a recreational sport (&gt;20 h/month). These were age-matched with 10 control subjects not performing climbing activities.ResultsMean age was 32.4 years for the climbing group and 25.8 years for the controls. Mean T2 values for the 5 different ROIs were 42.2 ± 7.8 msec for climbers and 41.4 ± 6.8 msec for non-climbers. No significant differences were observed for T2 values between both groups. However, higher age had a significant impact on T2 values for all assessed ROIs (higher age 44.2 ± 9.5, younger age 32.9 ± 5.7, p = 0.001).DiscussionThis study evaluated the cartilage composition of young, engaged climbers with a T2 mapping MRI technique with the purpose to depict early onset joint changes. No negative impact on cartilage composition due to the sport activity was found, whereas age-related effects on the cartilage seemed to be more prominent.
Evaluating factors influencing Tennessee and Kentucky farmers’ willingness to sell produce through fresh stop markets
Authors: Denton Riley , Velandia Margarita , Yenerall Jackie , DeLong Karen , Trejo-Pech Carlos , Chen Xuqi , Tanaka Keiko , Rignall Karen , Schexnayder Susan 
Published: September 2023

IntroductionThe food justice movement focuses on resolving food system inequalities, including, but not limited to, income, ethnicity, and race differences related to household access to food, farmer access to markets, and the fair treatment of farmworkers. Previous studies have focused on food system inequalities from the consumer demand side, but only a few studies have focused on the role farmers play in creating more equitable food systems. An example of a market model aiming to fulfill various missions of the food justice movement is Fresh Stop Markets (FSMs). FSMs aggregate food from local farmers and sell shares on a sliding scale based on consumers’ income. Lower income households pay less than higher-income households for the same food. A vital component of this market concept is farmers’ willingness to sell produce through FSMs.MethodsWe used data from a 2020 survey of Tennessee and Kentucky fruit and vegetable farmers and the double-bounded dichotomous choice contingent valuation approach to assess farmers’ willingness to sell produce through FSMs when faced with a price discount scenario. A probit regression was used to investigate the factors correlated with farmers’ willingness to sell produce through FSMs.Results and discussionResults suggest gross farm revenue, farmer age, education, experience selling produce through farmers markets, and running programs on the farm to educate communities about sustainable agriculture and food systems are associated with farmers’ willingness to sell produce through FSMs.ConclusionFarmer and farm business characteristics, as well as prior experience running education programs on the farm related to sustainable agriculture and food systems are important factors to consider when trying to engage farmers willing to sell produce through FSMs.
Comparison of standard T2-weighted turbo spin echo and volumetric interpolated breath-hold examination magnetic resonance imaging sequences in the assessment of articular process dysplasia in Pug dogs with thoracolumbar myelopathy
Authors: Gilbert Emma , Rose Jeremy , Arrol Lorna , Driver Colin J. 
Published: September 2023

IntroductionA retrospective study to compare the classification, as normal, hypoplastic or aplastic, of thoracic (T10-T13) caudal articular process (CAP) morphology in Pug dogs with a thoracolumbar myelopathy as normal, hypoplastic or aplastic, between T2 weighted Turbo Spin Echo (T2W-TSE), in sagittal and transverse planes, and Volumetric Interpolated Breath-hold Examination (VIBE) Magnetic Resonance Imaging (MRI) sequences, in comparison to Computed Tomography (CT). We hypothesized a stronger agreement for VIBE in comparison to T2W-TSE.ResultsDiagnostic accuracy of T2W-TSE was inferior to VIBE for aplastic (60%, 95% CI 0.561–0.639 vs. 78%, 95%CI 0.744–0.815) hypoplastic (44%, 95%CI 0.427–0.452 vs. 62.5%, 95%CI 0.595–0.655) and normal CAP (70%, 95%CI 0.655–0.744 vs. 87%, 95%CI 0.848–0.892). Superior accuracy of classification using VIBE vs. T2W-TSE sequences using the McNemar Chi squared test was significant for aplastic (p = 0.0002) and normal CAP (p = 0.004). VIBE sequences had a sensitivity of 96% and specificity of 75% to detect CAP abnormality and with T2W-TSE imaging sensitivity 81% and specificity of 75%.DiscussionThree-dimensionally reconstructable VIBE sequences were significantly more accurate than traditional T2W-TSE MRI sequences in classifying CAP morphology, which should reduce the need for CT for pre-operative assessment.
Transcriptome Analysis of Streptococcus mutans Quorum Sensing-Mediated Persisters Reveals an Enrichment in Genes Related to Stress Defense Mechanisms
Authors: Dufour Delphine , Li Haowen , Gong Siew-Ging , Lévesque Céline M. 
Published: September 2023

Persisters are a small fraction of growth-arrested phenotypic variants that can survive lethal concentrations of antibiotics but are able to resume growth once antibiotics are stopped. Their formation can be a stochastic process or one triggered by environmental cues. In the human pathogen Streptococcus mutans, the canonical peptide-based quorum-sensing system is an inducible DNA repair system that is pivotal for bacterial survival. Previous work has shown that the CSP-signaling peptide is a stress-signaling alarmone that promotes the formation of stress-induced persisters. In this study, we exposed S. mutans to the CSP pheromone to mimic DNA damage conditions and isolated the antibiotic persisters by treating the cultures with ofloxacin. A transcriptome analysis was then performed to evaluate the differential gene expression between the normal stationary-phase cells and the persisters. RNA sequencing revealed that triggered persistence was associated with the upregulation of genes related to several stress defense mechanisms, notably, multidrug efflux pumps, the arginine deaminase pathway, and the Opu/Opc system. In addition, we showed that inactivation of the VicK kinase of the YycFG essential two-component regulatory system abolished the formation of triggered persisters via the CSP pheromone. These data contribute to the understanding of the triggered persistence phenotype and may suggest new therapeutic strategies for treating persistent streptococcal infections.
Effect of Anemia on Physical Function and Physical Activity in CKD: The National Health and Nutrition Examination Survey, 1999–2016
Authors: Farag Youssef M.K. , Blasco-Colmenares Elena , Zhao Di , Sanon Myrlene , Guallar Eliseo , Finkelstein Fredric O. 
Published: September 2023

Key Points

In a large sample representative of the US adult noninstitutionalized population, among participants with CKD stages 3–5, anemia was associated with a significantly lower level of physical activity.The presence of CKD and anemia showed a positive interaction on physical functioning outcomes. Among participants with CKD, physical functioning was worse in patients with anemia compared with those without anemia.

Background
CKD is a major public health problem worldwide. Anemia, a frequent and treatable complication of CKD, is associated with decreased physical functioning and physical activity. The objective of this study was to evaluate the joint association of CKD and anemia with physical functioning and physical activity in a representative sample of the US population.

Methods
Cross-sectional study using the National Health and Nutrition Examination Survey (NHANES) 1999–2016 for physical functioning outcomes (N=33,300) and NHANES 2007–2016 for physical activity (N=22,933). The NHANES physical functioning questionnaire included 19 items. The NHANES physical activity questionnaire captured work-related, leisure-time, and sedentary activities. Higher physical functioning scores represent worse function. CKD was classified using Kidney Disease Outcomes Quality Initiative 2002 criteria, and anemia was defined using the World Health Organization criteria.

Results
The adjusted mean differences (95% confidence interval) in overall physical functioning score comparing participants with anemia with those without anemia among participants with no CKD, CKD stages 1–2, and stages 3–5 were 0.5 (−0.1 to 1.0), 1.5 (0.2 to 2.8), and 3.6 (2.0 to 5.2). Anemia and CKD showed a supra-additive interaction for all physical functioning outcomes among participants in CKD stages 3–5. The prevalence of high physical activity was also lower in participants with anemia compared with those without anemia among participants in CKD stages 3–5 (adjusted prevalence ratio, 0.74; 95% confidence interval, 0.54 to 1.01).

Conclusions
CKD and anemia were associated with impairments in physical functioning and reduced physical activity. For physical functioning outcomes, the combined presence of CKD and of anemia showed a stronger effect than what was expected from their independent effects.