bluuebunny/crossref_metadata_2025_split huggingface dataset:
Flow‐ and Fracture‐Driven Bubble Throat Growth Rates and Dynamic Permeability in Crystallizing Magma
Authors: Moitra P. , Albadi A. , Tatsch A. , Santra P. 
Published: January 2025

AbstractPyroclasts typically exhibit coalesced vesicle textures, which are the evidence of bubble coalescence and the incomplete bubble wall retraction in magma during volcanic eruptions. The sizes of bubble throats or inter‐bubble apertures in permeable networks control the extent of magma outgassing, and therefore, quantifying the growth rates of the bubble throats is important but has remained poorly constrained. Using dynamically similar experiments with spontaneous bursting of a single bubble in rheologically well‐characterized particulate suspensions, we investigate the growth rate of bubble throats for a range of particle volume fractions. For suspensions with 0.50 particle volume fraction, a circular hole (bubble throat) forms following bubble bursting, which after an initial fast growth starts plateauing at a throat‐bubble size ratio of 0.20. The throat growth time scale overall increases with increasing particle volume fraction due to the increase in suspension viscosity. On the other hand, bubbles in suspensions with particle volume fraction near the maximum packing fraction (0.64) exhibit a fracture‐like opening. Thus, our experimental results suggest that the plateauing of the bubble throat growth in crystal‐poor to crystal‐rich magma likely contributes to the wide occurrence of the incompletely retracted vesicle walls in pyroclasts. The implications of the flow‐ to fracture‐like growth of bubble throats on the development of dynamic permeability in magma are discussed.
Oncolytic reprogramming of tumor microenvironment shapes CD4 T-cell memory via the IL6ra-Bcl6 axis for targeted control of glioblastoma
Authors: Grimes Jeffrey M. , Ghosh Sadashib , Manzoor Shamza , Li Li X. , Moran Monica M. , Clements Jennifer C. , Alexander Sherrie D. , Markert James M. , Leavenworth Jianmei W. 
Published: January 2025

Abstract
Oncolytic viruses (OVs) emerge as a promising cancer immunotherapy. However, the temporal impact on tumor cells and the tumor microenvironment, and the nature of anti-tumor immunity post-therapy remain largely unclear. Here we report that CD4+ T cells are required for durable tumor control in syngeneic murine models of glioblastoma multiforme after treatment with an oncolytic herpes simplex virus (oHSV) engineered to express IL-12. The upregulated MHCII on residual tumor cells facilitates programmed polyfunctional CD4+ T cells for tumor control and for recall responses. Mechanistically, the proper ratio of Bcl-6 to T-bet in CD4+ T cells navigates their enhanced anti-tumor capacity, and a reciprocal IL6ra-Bcl-6 regulatory axis in a memory CD4+ T-cell subset, which requires MHCII signals from reprogrammed tumor cells, tumor-infiltrating and resident myeloid cells, is necessary for the prolonged response. These findings uncover an OV-induced tumor/myeloid-CD4+ T-cell partnership, leading to long-term anti-tumor immune memory, and improved OV therapeutic efficacy.
Artificial intelligence based prediction and multi-objective RSM optimization of tectona grandis biodiesel with Elaeocarpus Ganitrus
Authors: Kannan V Vinoth , Kanabar Bhavesh , Gowrishankar J , Khatibi. Ali , Kamangar Sarfaraz , Arabi Amir Ibrahim Ali , Thomai Pushparaj , Lozanović Jasmina 
Published: January 2025

Abstract
Meta-heuristic optimization algorithms are widely applied across various fields due to their intelligent behavior and fast convergence, but their use in optimizing engine behavior remains limited. This study addresses this gap by integrating the Design of Experiments-based Response Surface Methodology (RSM) with meta-heuristic optimization techniques to enhance engine performance and emissions characteristics using Tectona Grandi’s biodiesel with Elaeocarpus Ganitrus as an additive. Advanced Machine Learning (ML) models, including Artificial Neural Networks (ANN), K-Nearest Neighbors (KNN), Extreme Gradient Boosting (XGB), and Random Trees (RT), were employed for predictive analysis, with ANN outperforming RSM in accuracy. The study identified the Teak biodiesel blend (TB20) with a 5 ml Elaeocarpus Ganitrus additive (TB20 + R5) as the optimal formulation, achieving the highest Brake Thermal Efficiency and reduced Brake-Specific Fuel Consumption. Desirability analysis further confirmed the blend’s superior performance and emissions characteristics, with a desirability rating of 0.9282. This work highlights the potential of hybrid optimization approaches for improving biodiesel performance and emissions without engine modifications, contributing to the advancement of sustainable energy practices in internal combustion engines.
Effectiveness of iNTS vaccination in sub-Saharan Africa
Authors: Cassese Daniele , Dimitri Nicola , Breghi Gianluca , Spadafina Tiziana 
Published: January 2025

Abstract
Invasive non-Typhoidal Salmonella (iNTS) is one of the leading causes of blood stream infections in Sub-Saharan Africa, especially among children. iNTS can be difficult to diagnose, particularly in areas where malaria is endemic, and difficult to treat, partly because of the emergence of antibiotic resistance. We developed a mathematical model to evaluate the impact of a vaccine for iNTS in 49 countries of sub-Saharan Africa. Without vaccination we estimate 9.2 million new iNTS cases among children below 5 years old in these 49 countries from 2022 to 2038, 6.2 million of which between 2028 and 2038. The introduction of a
$$85\%$$
(
$$95\%$$
) efficacy vaccine in 2028 would prevent 2.6 (2.9) million of these new infections. We provide the country-specific impact of a iNTS vaccine considering the different age structures and vaccine coverage levels.
Zika virus modulates human fibroblasts to enhance transmission success in a controlled lab-setting
Authors: Mozūraitis Raimondas , Cirksena Karsten , Raftari Mohammad , Hajkazemian Melika , Mustapha Abiodun Musa , Brahimi Juela , Radžiutė Sandra , Apšegaitė Violeta , Bernotienė Rasa , Ignatowicz Lech , Hick Tessy , Kirschning Andreas , Lenman Annasara , Gerold Gisa , Emami S. Noushin 
Published: January 2025

Abstract
Transmission of Zika virus (ZIKV) has been reported in 92 countries and the geographical spread of invasive virus-borne vectors has increased in recent years. Arboviruses naturally survive between vertebrate hosts and arthropod vectors. Transmission success requires the mosquito to feed on viraemic hosts. There is little specific understanding of factors that may promote ZIKV transmission-success. Here we show that mosquito host-seeking behaviour is impacted by viral infection of the vertebrae host and may be essential for the effective transmission of arboviruses like ZIKV. Human skin fibroblasts produce a variety of metabolites, and we show that ZIKV immediately alters gene/protein expression patterns in infected-dermal fibroblasts, altering their metabolism to increase the release of mosquito-attractive volatile organic compounds (VOCs), which improves its transmission success. We demonstrate that at the invasion stage, ZIKV differentially altered the emission of VOCs by significantly increasing or decreasing their amounts, while at the transmission stage of the virus, all VOCs are significantly increased. The findings are complemented by an extensive meta-proteome analysis. Overall, we demonstrate a multifaceted role of virus-host interaction and shed light on how arboviruses may influence the behaviour of their vectors as an evolved means of improving transmission-success.
Claudin-11 regulates immunological barrier formation and spermatogonial proliferation through stem cell factor
Authors: Sugawara Taichi , Sonoda Kayoko , Chompusri Nattapran , Noguchi Kazuhiro , Okada Seiji , Furuse Mikio , Wakayama Tomohiko 
Published: January 2025

Abstract
Tight junctions (TJs) between adjacent Sertoli cells are believed to form immunological barriers that protect spermatogenic cells expressing autoantigens from autoimmune responses. However, there is no direct evidence that Sertoli cell TJs (SCTJs) do indeed form immunological barriers. Here, we analyzed male mice lacking claudin-11 (Cldn11), which encodes a SCTJ component, and found autoantibodies against antigens of spermatocytes/spermatids in their sera. Defective spermatogenesis in Cldn11-deficient mice was not restored on a recombination activating gene 2 (Rag2) knockout background lacking mature T and B lymphocytes. This suggests that adaptive immune responses to spermatogenic cells are not a cause of defective spermatogenesis in Cldn11-deficient mice. Further analyses showed that Cldn11 knockout impaired Sertoli cell polarization, localization of stem cell factor (SCF) (a key molecule for maintaining differentiating spermatogonia) to the basal compartment of seminiferous tubules, and also proliferation of differentiating spermatogonia. We propose that CLDN11 creates a microenvironment for SCF-mediated spermatogonial proliferation at the basal compartment via Sertoli cell polarization.
Societal changes in Ancient Greece impacted terrestrial and marine environments
Authors: Koutsodendris Andreas , Maran Joseph , Kotthoff Ulrich , Lippold Jörg , Knipping Maria , Friedrich Oliver , Gerdes Axel , Kaboth-Bahr Stefanie , Bahr André , Schulz Hartmut , Sakellariou Dimitris , Pross Jörg 
Published: January 2025

Abstract
The Aegean hosts some of the earliest cultural centers in European antiquity. To reconstruct the evolution of early anthropogenic impact in this region, we have examined lead (Pb) contents and vegetation dynamics on well-dated environmental archives extending to the early Holocene. We show that the impact of agropastoral societies on terrestrial ecosystems was locally confined during the Bronze and Iron Ages (5200–2750 years ago), although we record an onset of Pb pollution already at 5200 cal. years BP and thus about 1200 years earlier than previous archeological evidence. Our data demonstrate a marked increase in Pb pollution at 2150 cal. years BP that left an imprint across terrestrial and marine settings of the Aegean region. This first manifestation of marine pollution coincides with maximum deforestation and agricultural expansion, signaling pervasive human impact on ecosystems connected to the advanced monetized societies during the Hellenistic and Roman periods in Ancient Greece.
Ocean submesoscale fronts induce diabatic heating and convective precipitation within storms
Authors: Vivant Félix , Siegelman Lia , Klein Patrice , Torres Hector S. , Menemenlis Dimitris , Molod Andrea M. 
Published: January 2025

Abstract
The intensity of atmospheric storms is influenced by ocean temperature contrasts. While mesoscale sea surface temperature anomalies ( ~ 200 km-size) are known to intensify storms via latent heat release, the role of finer oceanic scales remains unknown. Using a global coupled ocean-atmosphere simulation at a km-scale resolution, we show that half of latent heat flux variability is driven by oceanic motions at the meso- ( ~ 40%) and submesoscale ( ~ 10-20 km-size, < 10%) in the Kuroshio Extension during winter. Additionally, ocean submesoscale fronts, with temperature gradients of 5 °C per 10 km, induce a secondary circulation reaching 4 km within the troposphere, which enhances diabatic processes and convective precipitations within storms. In the warm sector of storms, ocean submesoscale fronts locally account for half the total precipitations, averaging 14 mm day−1 over five days. As such, ocean submesoscale fronts pump moisture from the ocean to the atmosphere and have the potential to affect storm intensification.
Laser-assisted thermoelectric-enhanced hydrogen peroxide biosensors based on Ag2Se nanofilms for sensitive detection of bacterial pathogens
Authors: Ma Huangshui , Pu Shiyu , Jia Shiyu , Xu Shengduo , Yu Qiwei , Yang Lei , Wu Hao , Sun Qiang 
Published: January 2025

This study presents a thermoelectric biosensor using Ag2Se nanofilms on 3D-printed resin for precise H2O2 detection. It accurately quantifies S. sanguinis and MRSA, achieving a detection threshold of 104 CFU ml−1, meeting clinical standards.
Incremental shape integration with inter‐frame shape consistency using neural SDF for a 3D endoscopic system
Authors: Furukawa Ryo , Kawasaki Hiroshi , Sagawa Ryusuke 
Published: January 2025

Abstract3D measurement for endoscopic systems has been largely demanded. One promising approach is to utilize active‐stereo systems using a micro‐sized pattern‐projector attached to the head of an endoscope. Furthermore, a multi‐frame integration is also desired to enlarge the reconstructed area. This paper proposes an incremental optimization technique of both the shape‐field parameters and the positional parameters of the cameras and projectors. The method assumes that the input data is temporarily sequential images, that is, endoscopic videos, and the relative positions between the camera and the projector may vary continuously. As solution, a differential volume rendering algorithm in conjunction with neural signed distance field (NeuralSDF) representation is proposed to simultaneously optimize the 3D scene and the camera/projector poses. Also, an incremental optimization strategy where the optimized frames are gradually increased is proposed. In the experiment, the proposed method is evaluated by performing 3D reconstruction using both synthetic and real images, proving the effectiveness of our method.
Effect of field‐induced dynamic parameters on the electric field distortion characteristic of high voltage oil‐immersed bushing
Authors: Zhang Mingze , Wang Bingjie , Liu Ji , Yun Hao , Li Dexin , Yu Muhe , Sun Yufei , Zhao Chunming 
Published: January 2025

AbstractAs an important component of oil‐immersed transformers, the bushing's internal insulation ageing and dampness after the long‐term operation can cause changes in the internal electric and temperature fields, seriously threatening its safe operation. This paper tested the power frequency permittivity and direct current conductivity of aged and damp oil‐paper insulation samples at different testing temperatures, and constructed a dynamic dielectric parameter calculation model. Meanwhile, a simulation model was established based on the actual structure of the 252 kV/1250 A bushing which is mainly used for the oil‐immersed high‐voltage bushings of 110 kV and above. The electric‐magnetic‐thermal multi‐physical fields were used for simulation analysis. The influence of ageing/moisture (different degrees of dampness in the upper and lower regions) on the electric field distribution in the bushing was obtained. During the initial to steady‐state process, the electric field distribution at the zero and end shield shows a reversal phenomenon. When the capacitor core has different degrees of dampness in the upper and lower regions, the impedance distribution of the capacitor core is non‐uniform. This phenomenon will lead to an increase in the radial electric field gradient at the end shield of the capacitor core, which is prone to the risk of slip‐flashing discharge. In summary, this paper adopts the field‐induced dynamic parameters method to analyse the changes of multi‐physical fields in the bushing. This can provide theoretical guidance for optimising the bushing structure and on‐site maintenance.
Treatment and Outcome of Ductal Carcinoma in Situ for the German Federal States Berlin and Brandenburg in the Period 2007–2020
Authors: Burmeister Sandy , Jóźwiak Katarzyna , Richter-Ehrenstein Christiane , Buchali André , Holmberg Christine , von Rüsten Anne , Schneider Constanze , Hauptmann Michael 
Published: January 2025

AbstractDuctal carcinoma in situ (DCIS) of the female breast is treated with surgery possibly followed by radiotherapy (RT) and/or adjuvant hormonal therapy despite their known long-term side effects. Since not every DCIS will progress into an invasive breast cancer (IBC), disease progression and de-escalation of treatment is an important topic of current research.During 2007–2020, 3905 individuals with a DCIS diagnosis were reported to the cancer registry of Brandenburg and Berlin. We selected 3424 women who were cancer-free prior to DCIS diagnosis and without synchronous diagnoses of DCIS or ipsilateral IBC (iIBC). The objective was to describe changes over time in DCIS treatment and risk of developing iIBC by treatment.We observed decreasing proportions of mastectomy, breast-conserving surgery (BCS) with RT, and standard versus hypofractionated RT over time. During a median follow-up of 3.8 years, 105 women developed iIBC. Compared with BCS + RT with standard fractionation (54.9%, 1878/3424, 53 iIBC events), hazard ratios (HR) for ilBC were 0.72 (95% confidence interval [CI] 0.26, 1.99; 4 events) for BCS + hypofractionated RT, 0.70 (95% CI 0.33, 1.41; 11 events) for BCS alone, and 0.83 (95% CI 0.50, 1.37; 26 events) for mastectomy. Analyses were adjusted for DCIS size, grade, residual tumor status and ECOG score.We observed a de-escalation of treatment over time, with fewer mastectomies, less RT, and more hypofractionation of RT. No substantial differences in risk of iIBC were observed between these treatments. There is a need to evaluate DCIS treatment de-escalation in larger cohorts with longer follow-up.
Impacts on Postoperative Bleeding of Surgery for Head and Neck Malignancies While Continuing Antithrombotic Agents
Authors: Ushiro Koji , Asato Ryo , Ishida Hiroki , Chikugo Chisato , Ito Yukiko , Tsuji Takuya , Tsuji Jun 
Published: January 2025

Abstract
Introduction Perioperative management of antithrombotic agents may affect bleeding and lead to thromboembolic complications, but there is no consensus on optimal protocol in head and neck surgery.
Objective To explore the effect of antithrombotic agents on postoperative bleeding.
Methods We compared clinical characteristics, type of surgery, antithrombotic agents, continued use of medication or not, and frequency of postoperative bleeding among patients who were receiving antithrombotic therapy at the time of their decision to undergo surgery for head and neck malignancies, from 2008 to 2022.
Results A total of 168 patients were included. There was no significant difference in the incidence of intraoperative blood loss or postoperative bleeding between the group that underwent surgery while on antithrombotic therapy and those that underwent surgery after antithrombotic therapy was discontinued. In particular, there was no increase in bleeding complications with antiplatelet agents, regardless of the type or number of agents used.
Conclusion Surgery for head and neck malignancies with continued antiplatelet therapy may not increase bleeding complications, regardless of the type of antiplatelet therapy and even when multiple agents are taken.
Design, modeling, and control of coaxial integrated macro–micro composite actuator with high-precision and long-stroke
Authors: Yu Caofeng , Zhang Qilong , Wei Yijun , Xiao Zhihao , Yang Kun , Li Baokun 
Published: January 2025

This paper presents a coaxial integrated macro–micro composite actuator. The macro-actuator of the macro–micro composite actuator is similar to a moving coil type voice coil motor, and a giant magnetostrictive actuator is installed coaxially inside it as a micro-actuator. In this work, kinetic models are established for both the macro-actuator and micro-actuator, and based on the models, an automatic disturbance rejection controller is adopted to control the macro-actuator, and a fuzzy sliding mode controller is adopted for the micro-actuator. In order to verify the actual performance of the proposed macro–micro composite actuator, a prototype was fabricated, and experimental results show that the macro-actuator can achieve a 10 mm step positioning error of 9 μm and a 30 mm step positioning error of 11 μm under a load of 1 kg. The resolution of the minimum PWM square wave change identification of the controlled micro-actuator is 0.047 μm, and the minimum displacement resolution of the micro-actuator is 0.15 μm. The micro-actuator is capable of achieving 1 μm steps with no displacement overshoot. In addition, when the positioning distance is 5 μm, there is a small amplitude overshoot of 0.18 μm. The final positioning accuracy of macro–micro composite positioning is within 350 nm.
The effect of international study programmes and languages spoken on Spanish university students’ sense of
Europeanness and place identity
Authors: Méndez-García María-del-Carmen , Machancoses Francisco H. 
Published: January 2025

Abstract
This study explores European identity formation by examining the role of international study programmes (ISPs) and
plurilingualism among Spanish undergraduate and postgraduate students. Using a custom-built survey administered to 871
respondents, the research analyzes how ISPs and students’ language profiles influence their sense of Europeanness, attachment to
Europe, and perception of the European Union (EU).
Findings show that students participating in or interested in ISPs have a more positive view of Europe and the EU,
while non-mobile students tend to exhibit stronger local identities and view Europe more neutrally or negatively. Additionally,
students with broader language repertoires are more likely to associate the EU with cultural diversity, while those primarily
speaking Spanish often connect it to challenges like unemployment. Proficiency in multiple European languages emerges as a key
factor in fostering a positive European orientation.
This study underscores the importance of ISPs and plurilingualism in shaping European identity with valuable
insights for internationalization strategies in higher education.
Final report of the supplementary comparison between NIMT and LNE on pressure standards in the range 50 MPa to 500 MPa of hydraulic gauge pressure
Authors: Wongthep Padipat , Otal Pierre , Rabault Thierry , Soyez Olivier 
Published: January 2025

Main text
This report describes the results of a bilateral supplementary comparison of hydraulic high-pressure standards between Laboratoire National de Métrologie et d'Essais (LNE) and National Institute of Metrology (Thailand) (NIMT) in order to check their degrees of equivalence in the pressure range from 50 MPa to 500 MPa in the gauge mode.
This comparison was carried out during the period from March to December 2015. The results of this comparison will be essential to support the calibration and measurement capabilities (CMCs) of NIMT. The pilot laboratory was NIMTwhich provided the transfer standard (TS). The TS was a Piston-Cylinder Unit (PCU) without any pressure balance nor mass set.
All the measurements were performed in accordance with the Technical Protocol prepared by NIMT and accepted by LNE.
This report presents the results of NIMT and LNE. All uncertainties in this report are the standard ones (k = 1).
To reach the main text of this paper, click on Final Report. Note that this text is that which appears in Appendix B of the BIPM key comparison database https://www.bipm.org/kcdb/.
The final report has been peer-reviewed and approved for publication by the CCM, according to the provisions of the CIPM Mutual Recognition Arrangement (CIPM MRA).