bluuebunny/crossref_metadata_2025_split huggingface dataset:
Computed tomographic features of clinically suspected rhinitis in domestic rabbits (Oryctolagus cuniculus)
Authors: Slusarek Anna , Muffat‐es‐Jacques Patricia , Coutant Thomas , Pignon Charly , Léchenault Guillaume , Mortier Jérémy 
Published: January 2025

AbstractBackgroundThe aim of this study was to characterise the computed tomographic (CT) findings in domestic rabbits with clinically suspected rhinitis and compare them with CT findings in rabbits without clinical signs of rhinitis.MethodsCT images of rabbits that underwent a CT of the head were retrospectively reviewed and any CT abnormalities were described. Statistical analysis was performed to detect any association between the CT findings and clinical signs of rhinitis, and also to assess if there was any association between rhinitis and otitis media, otitis externa or dental disease.ResultsThirty‐three of the 133 rabbits included in the study had soft tissue‐attenuating material within their nasal cavities and were therefore classified as having CT findings compatible with rhinitis. CT evidence of rhinitis was correlated with the presence of clinical signs of rhinitis and with the presence of otitis media. There was no statistical association between CT evidence of rhinitis and the presence of otitis externa or dental disease.LimitationsThe retrospective nature of the study, small sample size and lack of aetiological confirmation limit the conclusions that can be drawn from the findings.ConclusionClinical signs of rhinitis were associated with CT abnormalities consistent with rhinitis and CT evidence of otitis media. The results of this study provide useful information for CT assessment of the nasal cavities of domestic rabbits and can be used as a reference for the diagnosis of rhinitis in this species.
Computed Tomographic Anatomy of the Head in Cockatiel (Nymphicus hollandicus)
Authors: Kazemi Seyedmehran , Rezaei Mehdi , Alizadeh Siamak , Hosseinchi Mohammadreza 
Published: January 2025

ABSTRACTBackgroundNowadays, computed tomography (CT) scanning is one of the most practical and precise diagnostic imaging methods that can be utilized to evaluate the head in birds.ObjectivesThis study aimed to present the normal anatomical data of the head of the cockatiel (Nymphicus hollandicus) using the CT method. In this research, the features of this bird's head were investigated in terms of bones, joints, muscles, sinuses and other constituent tissues.MethodsThe current retrospective cross‐sectional study used carcasses of six adult cockatiels (Nymphicus hollandicus) (three males and three females) with an average age of 1–3 years and an average weight of 75–110 g. After preparing the CT images, the head of each parrot underwent gross anatomy studies.ResultsBased on the results, reconstructed CT images could identify most structures of the cockatiel (Nymphicus hollandicus) head. Parietal, mandible, occiput, maxillary, premaxillary, palatine, pterygoid, quadrate, temporal bones, epithelial membranes, external ear canal and bony labyrinth, ossicles and entoglossal bones, different parts of the infraorbital sinus, brain hemispheres and various parts of the eyeball and conchae of the nasal cavities were examined in CT images. The results related to the CT evaluation and anatomical examination of the cockatiel (Nymphicus hollandicus) head demonstrated a high correlation.ConclusionThe results of this research can be employed as a reference and a suitable atlas for identifying anatomical features, examining different species of the cockatiel (Nymphicus hollandicus), teaching anatomy and interpreting CT scan images, as well as performing clinical examinations and treating this type of parrot.
Advancing Multiple‐Use Water Services for Development in Low‐ and Middle‐Income Countries
Authors: Stellbauer Matt , Jepson Wendy , Lefore Nicole , Thomson Patrick 
Published: January 2025

ABSTRACTMultiple‐use water services (MUS) encompass a variety of water services that span the various livelihood strategies commonly seen in communities throughout low‐ and middle‐income countries. MUS approaches can secure water for development, but limited peer‐reviewed research comprehensively evaluates MUS. This review addresses a gap in the literature by tracing MUS as an international development strategy and evaluating the peer‐reviewed scholarship published between 1990 and 2023 to describe the status and trends. The review identifies MUS attributes (e.g., water productivity, economics, health and nutrition, and gender empowerment) and the persistent barriers to scaling and institutionalization (e.g., regulatory and governance barriers and water quality). It then concludes with gaps in research (e.g., private sector roles and business models, ability to pay, ecosystem services, and climate resilience). MUS has the potential to be implemented tactically to address the nexus of water, food, nutrition, and water quality challenges, if research can contribute to evidence for scalable solutions that sufficiently address local needs.
Rapid Review: Die Lebensqualität nach adulter allogener Nierentransplantation in den letzten 5 Jahren
Authors: Brunaiova Lujza , Cermak Stefanie , Koneval Lukas , Roth Beat , Schneidewind Laila 
Published: January 2025

Zusammenfassung

Hintergrund
In aktuellen Studien konnte gezeigt werden, dass das klinische Monitoring der Lebensqualität (HRQoL) frühzeitig hilft, Nierentransplantatversagen zu erkennen.

Fragestellung
Aufgrund des Potenzials, das in der Verbesserung der HRQoL für die Langzeitergebnisse der Nierentransplantation steckt, führten wir ein Rapid Review der letzten 5 Jahre zur Evaluation der Lebensqualität nach adulter allogener Nierentransplantation durch.

Material und Methoden
Es wurde eine schnelle Evidenzanalyse mittels Literaturrecherche in MEDLINE im Zeitraum 2019 bis 2024 durchgeführt.

Ergebnisse
Die primäre Literatursuche ergab 554 Treffer, schließlich konnten lediglich 12 Kohortenstudien eingeschlossen werden, davon 2 retrospektive und zehn prospektive Arbeiten. Nierentransplantierte Patienten haben eine bessere HRQoL als Patienten mit terminaler Niereninsuffizienz. Das HRQoL wird durch körperliche, psychische und soziale Faktoren beeinflusst. Eine weitere Verbesserung der HRQoL bzw. der primären Einflussfaktoren hat das Potenzial, die Ergebnisse der Nierentransplantation weiter zu verbessern. Allerdings fehlen Studien zur Identifikation geeigneter Interventionen. Interessante zu beeinflussende Faktoren könnten z. B. Atemwegsbeschwerden und Unterstützung bei der beruflichen Wiedereingliederung sein.

Diskussion
Zukünftige Studien sollten auf die Identifikation adäquater Interventionen zur weiteren Verbesserung der HRQoL bei Nierentransplantierten fokussieren.
Reference materials for food authentication
Authors: Ulberth Franz , Koeber Robert 
Published: January 2025

Abstract
The global food industry faces significant challenges in ensuring the safety and authenticity of food products. Economic adulteration and counterfeiting of food are estimated to cost the industry US$30–40 billion annually. Analytical testing plays a vital role in detecting food fraud. For ensuring the metrological traceability and comparability of testing results, the use of reference materials (RMs) is crucial. The article describes the role of RMs in food authenticity testing, including their applications in method validation, calibration, quality control, and the definition of conventional measurement scales. It also reviews the availability of RMs that can be used in measurement procedures to authenticate food. Furthermore, the applications of RMs in targeted adulterant detection methods, for compositional parameters used to authenticate foods and food supplements, isotopic measurements, untargeted food authenticity testing methods, and detection and quantification of genetically modified organisms (GMOs), are explored. The document concludes by recommending the development of research grade test materials or representative test materials to harmonise untargeted testing methods and improve comparability of results across laboratories and over time.
Deletion of atypical type II restriction genes in Clostridium cellulovorans using a Cas9-based gene editing system
Authors: Schöllkopf Aline I. , Almeida Luciana , Krammer Karina , Rivero Cristina González , Liebl Wolfgang , Ehrenreich Armin 
Published: January 2025

Abstract
The anaerobic bacterium Clostridium cellulovorans is a promising candidate for the sustainable production of biofuels and platform chemicals due to its cellulolytic properties. However, the genomic engineering of the species is hampered because of its poor genetic accessibility and the lack of genetic tools. To overcome this limitation, a protocol for triparental conjugation was established that enables the reliable transfer of vectors for markerless chromosomal modification into C. cellulovorans. The availability of reporter genes is another requirement for strain engineering and biotechnological applications. In this work, the oxygen-free fluorescence absorption-shift tag (FAST) system was used to characterize promoter strength in C. cellulovorans. Selected promoters were used to establish a CRISPR/Cas system for markerless chromosomal modifications. For stringent control of expression of Cas9, a theophylline-dependent riboswitch was used, and additionally, the anti-CRISPR protein AcrIIA4 was used to reduce the basal activity of the Cas9 in the off-state of the riboswitch. Finally, the newly established CRISPR/Cas system was used for the markerless deletion of the genes encoding two restriction endonucleases of a type II restriction-modification (RS) system from the chromosome of C. cellulovorans. In comparison to the WT, the conjugation efficiency when using the deletion mutant as the recipient strain was improved by about one order of magnitude, without the need for prior C. cellulovorans-specific in vivo methylation of the conjugative plasmid in the E. coli donor strain.

Key points

• Quantification of heterologous promoters enables rational choice for genetic engineering.

• CRISPR/Cas with riboswitch and anti-CRISPR allows efficient gene deletion in C. cellulovorans.

• Conjugation protocol and type II REase deletion enhance genetic accessibility.
A boundary-based fourier neural operator (B-FNO) method for efficient parametric acoustic wave analysis
Authors: Li Ruoyan , Ye Wenjing , Liu Yijun 
Published: January 2025

Abstract
Repetitive wave analysis is required in various applications involving parametric analyses across different settings. However, traditional numerical methods based on domain discretization become computationally impractical due to the large number of simulations required, especially in unbounded domains. The boundary element method (BEM) is known for its effectiveness in solving wave equations, particularly in unbounded domains. Nevertheless, even with accelerated techniques, large-scale problems and those with high frequencies often necessitate numerous iterations, hampered by ill-conditioned system matrices. As a result, BEM becomes unsuitable for parametric analysis. To address these challenges, surrogate modelling techniques have been developed, and recent advancements in neural operators show promise in constructing surrogate models. However, they still face limitations when efficiently handling exterior and high-dimensional problems. In this study, we propose a novel data-driven surrogate modelling approach called B-FNO, which combines BEM and Fourier neural operator (FNO) for wave analysis in varying domains and frequencies. This approach formulates wave equations as integral formulations and utilizes FNO to map problem boundaries and other parameters to boundary solutions. Compared to existing surrogate modelling techniques, the B-FNO approach offers several advantages. These include reduced problem dimensionality and computational complexity, the ability to handle exterior problems without domain truncation, and significantly improved efficiency and accuracy compared to well-known neural network surrogate models. Moreover, compared to accelerated BEM, the B-FNO approach is better behaved and requires a much smaller number of iterations. We validate the effectiveness of our method through numerical experiments on a series of 2D and 3D benchmark problems, demonstrating its potential for broad application.
Co-infections of rickettsiales in clinically healthy, Leishmania infantum seropositive and seronegative dogs: a systematic literature review and new findings from Southern Italy
Authors: Gusatoaia Oana , Perles Livia , Cavalera Maria Alfonsa , Uva Annamaria , Gernone Floriana , Otranto Domenico , Zatelli Andrea 
Published: January 2025

Abstract
Canine leishmaniosis (CanL), caused by Leishmania infantum, is a widespread vector-borne disease. In Italy, an endemic region for CanL, overlapping transmission of L. infantum and tick-borne pathogens (TBPs) like Anaplasma phagocytophilum and Ehrlichia canis is increasingly reported. Dogs with clinical leishmaniosis often show higher co-infection rates and pronounced clinicopathological abnormalities. This study presents a systematic literature review and new findings from southern Italy, focusing on co-infections with E. canis and A. phagocytophilum in clinically healthy L. infantum seropositive and seronegative dogs. The systematic review identified two eligible studies. The first reported 34/488 (7%) dogs L. infantum seropositive, with 11.8% also seropositive for A. phagocytophilum. Among 454 seronegative dogs, 3% were seropositive for A. phagocytophilum and 2.4% for E. canis. The second study identified 154/1260 (12.2%) dogs L. infantum seropositive, with co-infection rates of 0.6% and 1.9% for A. phagocytophilum and E. canis, respectively. Among 1106 seronegative dogs, 1.3% were seropositive for A. phagocytophilum and 2.3% for E. canis. In the retrospective study from southern Italy, 90/154 (58.4%) dogs were L. infantum seropositive, with co-infection rates of 4.4% for A. phagocytophilum and 2.2% for A. phagocytophilum and E. canis. Among 64 seronegative dogs, 1.6% showed similar co-infections. This is the first systematic review in Italy, documenting low and comparable co-infection rates with A. phagocytophilum and E. canis in clinically healthy dogs, regardless of L. infantum serostatus. These findings suggest that co-infections may occur independently, offering insights into vector-borne disease dynamics in endemic areas.
Teleoperation von mobilen Bergbaumaschinen
Authors: Sifferlinger Nikolaus August 
Published: January 2025

Zusammenfassung
Im Bergbau ist das Bestreben, möglichst wenige Bergleute an exponierten Orten zu haben, seit jeher vorhanden.
Seit den 1990er-Jahren wird die Möglichkeit der Teleoperation im Untertagebergbau erfolgreich eingesetzt. Dies ermöglicht zeitweise den Betrieb mobiler Montanmaschinen aus der Ferne.
Von einem mannlosen Betrieb sind wir aber untertage noch weit entfernt, da für den Ein- und Ausbau von Einrichtungen, Wartung und Reparatur und Behebung von ungeplanten Situationen der Mensch noch unersetzlich ist.
Im Jahr 2025 gibt es Teleoperationslösungen für die meisten mobilen Bergbaumaschinen. Dies erhöht Sicherheit und Produktivität, da auch während des Schichtwechsels die betroffene Maschine weiterarbeiten kann.
Für die Wartung und Reparatur müssen aber weiterhin Menschen vor Ort. Bis Reparaturroboter diese Aufgabe, wahrscheinlich auch durch Teleoperation unterstützt, übernehmen können, wird es noch einige Zeit dauern.
Implementation Determinants of PrEP and Behavioral Health Treatment Referral among HIV Test Counselors
Authors: Harkness Audrey , Morales Vanessa , Grealis Kyle , Reyes Nequiel , Feaster Daniel J. , Safren Steven , Turner DeAnne , Balise Raymond R. 
Published: January 2025

Abstract
Pre-exposure prophylaxis (PrEP), an effective biomedical prevention intervention, is not sufficiently reaching populations experiencing high HIV incidence. Behavioral health (BH) treatment addressing mental health and substance use similarly requires increased reach to HIV-affected populations. HIV testing is an opportunity to refer individuals to PrEP and BH treatment. This study, conducted in Miami-Dade County, FL, a domestic HIV epicenter, aimed to assess (1) self-reported rates at which HIV test counselors refer clients to PrEP and BH treatment, (2) barriers and facilitators to PrEP and BH treatment referral, and (3) the relationship between barriers and facilitators and test counselors’ referral rates. Among 127 HIV test counselors, the average PrEP referral rate was 63.8% (SD = 41.5) of those potentially meeting PrEP indications. Insufficient time was associated with lower PrEP referral (OR: 0.64, 95% CI: 0.42–0.99, p = 0.023) and training in PrEP screening was associated with higher rates of PrEP referral (OR: 1.27, 95% CI: 0.98–1.64, p = 0.034). The average BH treatment referral rate was 52.7% (SD = 44.4) of clients who the counselor felt would potentially benefit from treatment. Counselors lacking knowledge of screening (OR: 0.4, 95% CI: 0.2–0.78, p = 0.004), referral procedures (OR: 0.45, 95% CI: 0.23–0.87, p = 0.008), or locations to refer clients (OR: 0.47, 95% CI: 0.25–0.86, p = 0.008), as well as those with higher caseloads (OR: 0.998, 95% CI: 0.997–0.999, p < 0.001) were less likely to refer for BH. Training in substance use screening (OR: 1.26, 95% CI: 0.96–1.64, p = 0.046) and referral (OR: 1.28, 95% CI: 0.99–1.66, p = 0.029) were associated with increased BH referral. Implementation strategies are needed to address key barriers to PrEP and BH referrals in HIV testing contexts.
On Master-Length Scale Formulations for Stable Conditions in Turbulence Closure Models
Authors: Porretta-Tomaszewska Paola , Łobocki Lech 
Published: January 2025

Abstract
Three formulations of the turbulence-length scales used in numerical modelling of atmospheric flows are compared. The comparison is made using the Mellor–Yamada–Nakanishi–Niino turbulence closure model within the stable boundary layer local similarity framework. With an appropriate choice of model constants, the model predictions are barely discernible and compare well with the empirical data obtained from the SHEBA campaign.
Nonlinear Morphoelastic Theory of Biological Shallow Shells with Initial Stress
Authors: Andrini D. , Chen X. , Ciarletta P. 
Published: January 2025

Abstract
Shallow shells are widely encountered in biological structures, especially during embryogenesis, when they undergo significant shape variations. As a consequence of geometric frustration caused by underlying biological processes of growth and remodeling, such thin and moderately curved biological structures experience initial stress even in the absence of an imposed deformation. In this work, we perform a rigorous asymptotic expansion from three-dimensional elasticitiy to obtain a nonlinear morphoelastic theory for shallow shells accounting for both initial stress and large displacements. By application of the principle of stationary energy for admissible variation of the tangent and normal displacement fields with respect to the reference middle surface, we derive two generalised nonlinear equilibrium equations of the Marguerre-von Kármán type. We illustrate how initial stress distributions drive the emergence of spontaneous mean and Gaussian curvatures which are generally not compatible with the existence of a stress free configuration. We also show how such spontaneous curvatures influence the structural behavior in the solutions of two systems: a saddle-like and a cylindrical shallow shell.
Understanding Rangeland Desertification at the Village Level: A Comparative Study with a Social-Ecological Systems Perspective in Namibia
Authors: Schwieger Diego Augusto Menestrey , Munyebvu - Chambara Faith , Hamunyela Ndamonenghenda , Tielbörger Katja , Nesongano Wellencia C. , Bilton Mark C. , Bollig Michael , Linstädter Anja 
Published: January 2025

Abstract
Desertification poses significant environmental and socio-economic threats to pastoral systems within the drylands of sub-Saharan Africa. However, there remains a paucity of interdisciplinary studies delving into the anthropogenic drivers of desertification at the local level of social-ecological systems, resulting in an inadequate understanding of its human-induced causes. This research aims to bridge this gap by presenting three case studies from Namibia’s eastern communal areas. Through an integrated approach drawing from rangeland ecology and anthropology, we offer a comparative analysis revealing nuanced differences among individual pastoral settlements, shaped by their distinct social contexts. Our findings elucidate the social determinants influencing varying degrees of desertification at the village level, highlighting local factors that mitigate the adverse impacts of grazing pressure and aridity on perennial grass populations. Notably, the study identifies the role of social institutions in managing critical environmental conditions and physical infrastructures, such as extensive pastures and cattle posts, which contribute to maintaining grassland resilience. Despite observable signs of desertification, the presence of perennial grasses both aboveground and in the soil seed bank across all settlements suggests that a tipping point has not yet been reached, emphasizing the window of opportunity for intervention. The discussion extends to the potential transferability of these findings to other Namibian communities within the existing socio-ecological framework, aiming to avert impending tipping points. Ultimately, the study challenges the notion of desertification in pastoral social-ecological systems as solely a tragedy of the commons, emphasizing the imperative of developing and implementing suitable social institutions within colonial and post-colonial contexts.
ConfExp: Root-Cause Analysis of Service Misconfigurations in Enterprise Systems
Authors: Mohammadi Koushki Negar , El-Shekeil Ibrahim , Kant Krishna 
Published: January 2025

Abstract
Misconfiguration is a known and increasingly serious problem in enterprise systems due to frequent code updates and retuning of the configuration parameters. Diagnosing complex, residual misconfiguration problems that lead to inaccessible services or failed transactions often starts with either a user complaint or observation by administrators, followed by a largely manual process of deciding what tests to run and how to proceed with further testing based on the test results. The goal of this paper is to automate this process and thereby make root-cause analysis of accessibility related misconfigurations much speedier and much more effective. We explore a domain-knowledge-driven methodology, called ConfExp using a network emulator that runs real enterprise networking protocols. Thus, by using commonly used tests, we show that the root-cause can be determined in all cases where discriminative tests exist. The methodology also highlights areas where more discriminative tests are needed to pinpoint the precise configuration variables at fault.