bluuebunny/crossref_metadata_2025_split huggingface dataset:
Single domain von Willebrand factor type C “cytokines” and the regulation of the stress/immune response in insects
Authors: Labropoulou Vassiliki , Wang Luoluo , Magkrioti Christiana , Smagghe Guy , Swevers Luc 
Published: January 2024

AbstractThe single domain von Willebrand factor type C (SVWC) appears in small secreted peptides that are arthropod‐specific and are produced following environmental stress or pathogen exposure. Most research has focused on proteins with SVWC domain that are induced after virus infection and are hypothesized to function as “cytokines” to regulate the innate immune response. The expansion of SVWC genes in insect species indicates that many other functions remain to be discovered. Research in shrimp has elucidated the adaptability of Vago‐like peptides in the innate immune response against bacteria, fungi and viruses after activation by Jak‐STAT and/or Toll/Imd pathways in which they can act as pathogen‐recognition receptors or cytokine‐like signaling molecules. SVWC factors also appear in scorpion venoms and tick saliva, underlining their versatility to acquire new functions. This review discusses the discovery and function of SVWC peptides from insects to crustaceans and chelicerates and reveals the enormous gaps in knowledge that remain to be filled to understand this enigmatic group of secreted peptides.
Residual evaluation of fault detection in discrete‐time systems
Authors: Zhang Zhihao , Yao Tong , Han Weixin 
Published: January 2024

AbstractThis paper studies residual evaluation of fault detection in discrete‐time systems considering unknown‐but‐bounded disturbance. By applying Lyapunov stability principle and zonotopic technique, respectively, two dynamic threshold estimation methods are proposed to detect fault of discrete‐time systems. The proposed methods are extended to systems with time‐delay to improve the applicability in practical systems. The effectiveness and comparison of the proposed methods are illustrated by numerical examples.
Oculomotor randomness is higher in autistic children and increases with the severity of symptoms
Authors: Ziv Inbal , Avni Inbar , Dinstein Ilan , Meiri Gal , Bonneh Yoram S. 
Published: January 2024

AbstractA variety of studies have suggested that at least some children with autism spectrum disorder (ASD) view the world differently. Differences in gaze patterns as measured by eye tracking have been demonstrated during visual exploration of images and natural viewing of movies with social content. Here we analyzed the temporal randomness of saccades and blinks during natural viewing of movies, inspired by a recent measure of “randomness” applied to micro‐movements of the hand and head in ASD (Torres et al., 2013; Torres & Denisova, 2016). We analyzed a large eye‐tracking dataset of 189 ASD and 41 typically developing (TD) children (1–11 years old) who watched three movie clips with social content, each repeated twice. We found that oculomotor measures of randomness, obtained from gamma parameters of inter‐saccade intervals (ISI) and blink duration distributions, were significantly higher in the ASD group compared with the TD group and were correlated with the ADOS comparison score, reflecting increased “randomness” in more severe cases. Moreover, these measures of randomness decreased with age, as well as with higher cognitive scores in both groups and were consistent across repeated viewing of each movie clip. Highly “random” eye movements in ASD children could be associated with high “neural variability” or noise, poor sensory‐motor control, or weak engagement with the movies. These findings could contribute to the future development of oculomotor biomarkers as part of an integrative diagnostic tool for ASD.
A ternary nucleotide–lanthanide coordination nanoprobe for ratiometric fluorescence detection of ciprofloxacin
Authors: Weng Pei , Li Chunlan , Liu Qiuhua , Tang Zilong , Zhou Zaichun , Chen Shu , Hao Yuanqiang , Xu Maotian 
Published: January 2024

AbstractCiprofloxacin (CIP) is a widely used broad‐spectrum antibiotic and has been associated with various side effects, making its accurate detection crucial for patient safety, drug quality compliance, and environmental and food safety. This study presents the development of a ternary nucleotide–lanthanide coordination nanoprobe, GMP‐Tb‐BDC (GMP: guanosine 5′‐monophosphate, BDC: 2‐amino‐1,4‐benzenedicarboxylic acid), for the sensitive and ratiometric detection of CIP. The GMP‐Tb‐BDC nanoprobe was constructed by incorporating the blue‐emissive ligand BDC into the Tb/GMP coordination polymers. Upon the addition of CIP, the fluorescence of terbium ion (Tb3+) was significantly enhanced due to the coordination and fluorescence sensitization properties of CIP, while the emission of the BDC ligand remained unchanged. The nanoprobe demonstrated good linearity in the concentration range of 0–10 μM CIP. By leveraging mobile phone software to analyze the color signals, rapid on‐site analysis of CIP was achieved. Furthermore, the nanoprobe exhibited accurate analysis of CIP in actual drug and milk samples. This study showcases the potential of the GMP‐Tb‐BDC nanoprobe for practical applications in CIP detection.
Emission targeting and carbon emissions: The moderating effect of female directors
Authors: Nimer Khalil , Abdelqader Muath , Kuzey Cemil , Uyar Ali 
Published: January 2024

AbstractThis study first investigates emission reduction targeting among polluting firms in the basic materials sector. We assess whether firms that produce a greater amount of carbon emissions are more likely to set emission reduction targets in the basic materials sector. Further, we test whether female directors are influential in moderating between emission reduction targeting and carbon emissions. The sample covers publicly traded firms in the basic materials sector listed in the Thomson Reuters Eikon database between 2010 and 2021. We perform country and year fixed effects regression analysis, as the firms in the sample are from diverse countries. We find that firms that produce more carbon emissions are more likely to set emission reduction targets and that female directors negatively moderate the relationship between emission reduction targeting and carbon emissions. Thus, firms with more female directors on their boards are more likely to reduce their carbon emissions via emission reduction targeting.
Current trends and prospects of surgical techniques for hepatoblastoma
Authors: Pu Jia‐rui , Li Hang , Li Shuai , Wang Yong , Li Shi‐wang , Tang Shao‐tao 
Published: January 2024

AbstractHepatoblastoma, a common extracranial malignant solid tumor in childhood, is often detected at an advanced stage and is difficult to treat surgically. Despite the availability of multiple comprehensive treatments that can be combined with surgery, hepatoblastoma treatment outcomes remain poor. Surgery is the main treatment strategy for hepatoblastoma, but it faces many challenges, including tumor attachment to surrounding tissues, tumor wrapping or invading of vital organs and tissues, the presence of giant or multiple tumors, distant metastasis, the formation of a tumor thrombus, and significant surgical trauma. In this review, we discuss recent research advances and propose potential strategies for overcoming these challenges. Such strategies may improve the rate of hepatoblastoma resection and local control in children, as well as reduce complications and trauma.
The outcomes of different regimens depend on the molecular subtypes of pulmonary large‐cell neuroendocrine carcinoma: A retrospective study in China
Authors: Wang Zhaojue , Wu Yang , Lu Tao , Xu Yan , Chen Minjiang , Zhong Wei , Zhao Jing , Wang Mengzhao 
Published: January 2024

AbstractBackgroundThe optimal systemic treatment for pulmonary large‐cell neuroendocrine carcinoma (LCNEC) remains controversial, and recent advances in LCNEC molecular subtype classification have provided potential strategies for assisting in treatment decisions. Our study aimed to investigate the impact of treatment regimens, molecular subtypes and their concordance on clinical outcomes of patients diagnosed with LCNEC.Patients and MethodsAll patients diagnosed with advanced pulmonary LCNEC in Peking Union Medical College Hospital (PUMCH) between January 2000 and October 2021 were enrolled in this retrospective study. The tumor samples were collected and sequenced using a tumor‐specific gene panel, while clinical information was retrieved from the medical records system. The survival and therapeutic response were analyzed and compared between different subgroups classified by treatment regimen (SCLC or NSCLC‐based), molecular subtype (type I or II) or the combination.ResultsIn univariate subgroup analysis categorized only by treatment regimen or molecular subtype, there were no differences identified in DCR, ORR, PFS, or OS. Nevertheless, the group with consistent treatment regimen and molecular subtype exhibited significantly longer OS than that of the inconsistent group (median OS 37.7 vs. 8.3 months; p = 0.046). Particularly, the OS of patients with type II LCNEC treated with SCLC‐based regimen was significantly prolonged than that of others (median 37.7 vs. 10.5 months; p = 0.039).ConclusionsCollectively, our study revealed the clinical outcomes of different treatment regimens for LCNEC patients highly depend on their molecular subtypes, highlighting the need for sequencing‐guided therapy.
Awareness and interest in cannabis use for cancer management among cancer survivors
Authors: Osaghae Ikponmwosa , Talluri Rajesh , Chido‐Amajuoyi Onyema Greg , Tanco Kimberson , Shah Dimpy P. , Pande Mala , Shete Sanjay 
Published: January 2024

AbstractBackgroundWe examined the awareness, interest, and information sources relating to cannabis use for cancer management (including management of cancer symptoms and treatment‐related side effects) and determined factors associated with cancer survivors' awareness and interest in learning about cannabis use for cancer management.MethodsThis was a cross‐sectional study of adult cancer survivors (N = 1886) receiving treatment at a comprehensive cancer center. Weighted prevalence and multivariable logistic regression analyses were conducted.ResultsAmong cancer survivors, 88% were aware and 60% were interested in learning about cannabis use for cancer management. Common sources of information to learn about cannabis use for cancer management were cancer doctors/nurses (82%), other patients with cancer (27%), websites/blogs (26%), marijuana stores (20%), and family/friends (18%). The odds of being aware of cannabis use for cancer management was lower among male compared to female survivors (adjusted odds ratio [AOR]: 0.61; 95% confidence interval [CI]: 0.41–0.90), non‐Hispanic Blacks compared to non‐Hispanic Whites (AOR: 0.36; 95% CI: 0.21–0.62), and survivors who do not support the legalization of cannabis for medical use compared to those who do (AOR: 0.10; 95% CI: 0.04–0.23). On the other hand, the odds of being interested in cannabis use for cancer management was higher among non‐Hispanic Blacks compared to non‐Hispanic Whites (AOR: 1.65; 95% CI: 1.04–2.62), and among cancer survivors actively undergoing cancer treatment compared to patients on non‐active treatment (AOR: 2.25; 95% CI: 1.74–2.91).ConclusionAwareness of cannabis use for cancer management is high within the cancer survivor population. Results indicated health care providers are leading information source and should receive continued medical education on cannabis‐specific guidelines. Similarly, tailored educational interventions are needed to guide survivors on the benefits and risks of cannabis use for cancer management.
Wound Healing Effect of Lippia sidoides and Myracrodruon urundeuva Nanogel
Authors: Pires Rodrigues de Almeida Ribeiro Fernanda , Fernandes Matos Luana , Brito Queiroz Dinalva , Botelho Marco Antônio , de Souza Siqueira Barreto Dra.Rosana , Santana de Lima Ricardo , de Araújo Ribeiro Luciano Augusto , Rose Alencar de Menezes Irwin , Melo Coutinho Henrique Douglas , Guedes da Silva Almeida Jackson Roberto 
Published: January 2024

AbstractWound healing is a natural regenerative response to tissue injury and the conventional treatments consists of the use wound dressings with local administration of medicines, but, in some cases, are only partially effective and limited by toxicity or ineffective anti‐microbial protection. Medicinal plants such as Lippia sidoides and Myracrodruon urundeuva have shown interesting pharmacological activities, allied to this, the association of these medicinal plants and nanotechnology, could mean an advantage in relation to classical approach. This study investigated the effect of a nanogel loaded with Lippia sidoides essential oil and Myracrodruon urundeuva extract (NAA) in an excisional wound healing model in rats. Animals were anesthetized and skin wounds were made using a metal punch. The groups were treated with vehicle, NAA or collagenase gel, for 7, 14 or 21 days and then sacrificed for tissue analysis. NAA did not show acute dermal irritation, further significantly reduced (p<0.05) the final wound area, accelerated the wound contraction and organization of collagen in the group treated for 14 days. The data presented here demonstrate the therapeutic potential for the use of nanotechnology associated with medicinal plants and provides evidence that corroborate with the use of L. sidoides and M. urundeuva as healing medicinal plants.
Factors affecting dehulling of hairless canary seed (Phalaris canariensis L.)
Authors: Malunga Lovemore Nkhata , Ames Nancy , Hucl Pierre J. , Thandapilly Sijo J. 
Published: January 2024

AbstractBackground and ObjectivesCanary seed is a novel cereal grain that needs dehulling before being used in food applications. This work aimed to develop dehulling quality scoring criteria and study the hullability of Canary seeds. Methods for dehulling Canary seeds were studied using compressed air, impact, and abrasion‐type dehulling equipment. A response surface methodology (RSM) was used to design experiments to assess the effect of initial sample weight, heat treatment, tempering, and dehulling time on the dehulling efficiency and groat quality.FindingsThe results suggest that tempering level and starting weight had a significant (p < .0001) positive effect, whereas time and heat treatment had a negative effect on the dehulling efficiency. Compressed air dehulling resulted in reduced broken groats and groat abrasion compared to the impact dehulling conditions studied. An optimized method was used to study the effect of genotype and growing environment on the hullability of four hairless Canary seed varieties grown in two growing years at one location. The milling yield ranged from 57% to 67% and was affected by genotype (p < .0001), growing year (p < .001), and their interaction (p < .001).ConclusionsThe results suggest that breeding programs should consider the dehulling and milling quality of Canary seed. Apart from milling yield, the breeding programs and milling industry should also consider adopting visual assessment of the groat quality using the tool presented in this work.Significance and NoveltyIn this work, a visual assessment tool for Canary seed groat quality is developed that can be used for breeding programs and industry to compare sample performance. Also, our research has provided factors to be considered by the industry when dehulling hairless Canary seeds to maximize milling yield and groat quality.
Catalytic Continuous Reductive Amination with Hydrogen in Flow Reactors
Authors: Zhang Jiahao , Xu Yanlin , Li Yingying , Yin Jiabin , Zhang Jisong 
Published: January 2024

AbstractReductive amination with hydrogen is a green and atom‐efficient method to construct amines from accessible aldehydes and ketones. Flow reactors, with superior mass and heat transfer rate because of higher specific surface area, have emerged as a powerful tool to conduct reductive amination with high efficiency and selectivity. This article discusses the influence of catalysts, solvents, temperatures, additives, and substrate properties on reductive amination. Following this, a summary of research on reductive amination with hydrogen in flow reactors is provided. The investigations were classified based on distinct nitrogen sources, encompassing the use of ammonia, amines, and nitro compounds. Based on the influencing factors and reaction cases, the article analyzes the enhancement effects of temperature control, mass transfer intensification, and residence time distribution in flow reactors on the reductive amination. Finally, the article gives a conclusion by addressing challenges and prospects for further developments in this field.
“Covalent‐Disassembly”‐Based Approaches For Sensing Applications
Authors: Zelder F. 
Published: January 2024

AbstractThe detection of analytes with small molecular probes is crucial for the analysis and understanding of chemical, medicinal, environmental and biological situations as well as processes. Classic detection approaches rely on the concept of molecular recognition and bond formation reactions. Bond breakage reactions have been less explored in similar contexts. This concept article introduces metal‐salen and metal‐imine complexes as “covalent‐disassembly”‐based (DB)‐probes for detecting polyoxophosphates, thiols, amino acids, HCN and changes in pH. It discusses the roles, importance and combinations of structurally functionalized molecular building blocks in the construction of DB‐probes. Applications of optimized DB‐probes for analyte detection in live cells and foodstuff are also discussed. Furthermore, the mechanism of the disassembly of a Fe(III)‐salen probe upon pyrophosphate binding is presented. Extraordinary selectivity for this analyte was achieved by a multistep disassembly sequence including an unprecedented structural change of the metal complex (i. e. “induced‐fit” principle). Design principles of probes for sensing applications following the “covalent‐disassembly” approach are summarized, which will help improving current systems, but will also facilitate the development of new DB‐probes for challenging analytic targets.
Monomeric gold hydrides for carbon dioxide reduction: ligand effect on the reactivity
Authors: Rossi Elisa , Sorbelli Diego , Belanzoni Paola , Belpassi Leonardo , Ciancaleoni Gianluca 
Published: January 2024

AbstractWe analyzed the ligand electronic effect in the reaction between a [LAu(I)H]0/− hydride species and CO2, leading to a coordinated formate [LAu(HCOO)]0/−. We explored 20 different ligands, such as carbenes, phosphines and others, carefully selected to cover a wide range of electron‐donor and ‐acceptor properties. We included in the study the only ligand, an NHC‐coordinated diphosphene, that, thus far, experimentally demonstrated facile and reversible reaction between the monomeric gold(I) hydride and carbon dioxide. We elucidated the previously unknown reaction mechanism, which resulted to be concerted and common to all the ligands: the gold–hydrogen bond attacks the carbon atom of CO2 with one oxygen atom coordinating to the gold center. A correlation between the ligand σ donor ability, which affects the electron density at the reactive site, and the kinetic activation barriers of the reaction has been found. This systematic study offers useful guidelines for the rational design of new ligands for this reaction, while suggesting a few promising and experimentally accessible potential candidates for the stoichiometric or catalytic CO2 activation.
Total Synthesis of Ervaoffine J and K
Authors: Hughes Alexander J. , Townsend Steven D. 
Published: January 2024

AbstractHerein, we describe the total synthesis of ervaoffine J & K from a central intermediate. Ervaoffine J was synthesized in eight steps in 14 % yield. Our strategy features an aerobic Winterfeldt oxidation to introduce the 4‐quinolone moiety. Ervaoffine K was produced in ten steps and 10 % yield. The synthesis leveraged (bromodifluoromethyl)‐trimethylsilane to induce a regioselective von Braun‐type C−N bond fragmentation. This C−N bond cleavage unveiled the tetrasubstituted all‐syn cyclohexane core of ervaoffine K and enabled the completion of its synthesis.
Design Strategies toward High‐Utilization Zinc Anodes for Practical Zinc‐Metal Batteries
Authors: Xiao Jin , Yuan Chenbo , Xiang Le , Li Xiutao , Zhu Lingyun , Zhan Xiaowen 
Published: January 2024

AbstractAqueous Zn‐metal batteries (AZMBs) hold a promise as the next‐generation energy storage devices due to their low cost and high specific energy. However, the actual energy density falls far below the requirements of commercial AZMBs due to the use of excessive Zn as anode and the associated issues including dendritic growth and side reactions. Reducing the N/P ratio (negative capacity/positive capacity) is an effective approach to achieve high energy density. A significant amount of research has been devoted to increasing the cathode loading and specific capacity or tuning the Zn anode utilization to achieve low N/P ratio batteries. Nevertheless, there is currently a lack of comprehensive overview regarding how to enhance the utilization of the Zn anode to balance the cycle life and energy density of AZMBs. In this review, we summarize the challenges faced in achieving high‐utilization Zn anodes and elaborate on the modifying strategies for the Zn anode to lower the N/P ratio. The current research status and future prospects for the practical application of high‐performance AZMBs are proposed at the end of the review.
Mass Balance and Metabolite Profile after Single and Multiple Oral Doses of Pritelivir in Healthy Subjects
Authors: Bonsmann Susanne , McCormick David , Pausch Jörg , de Vries Michiel , Sumner Melanie , Birkmann Alexander , Zimmermann Holger , Kropeit Dirk 
Published: January 2024

AbstractPritelivir is a helicase‐primase inhibitor active against HSV. Two human mass balance trials (a multiple‐dose trial and a single‐dose trial) were performed to characterize the absorption, distribution, metabolism, and excretion of 100 mg oral pritelivir combined with a single microdose of 14C‐pritelivir. Blood, urine, and feces samples were collected up to 26 days postdose. The plasma half‐life of pritelivir was 63‐67 hours. Overall, 92% and 66% of the administered dose was recovered in the multiple and single dose trials, respectively. The low recovery after the single dose (66%) was most likely related to the formulation used. The major metabolic pathway was amide hydrolysis leading to amino thiazole sulfonamide (ATS) and pyridinyl phenyl acetic acid (PPA). In plasma, pritelivir, ATS, PPA, and PPA‐acyl glucuronide accounted for 40.6%, 9.4%, 5.1%, and 0.2% of total radioactivity. More than 90% of drug‐related material was eliminated 624 hours postdose. The majority was excreted in urine (75% and 77%), followed by feces (16% and 23%). The main components in urine were PPA‐acyl glucuronide (and its isomers), ATS, and its N‐demethylated isomers. Only minor metabolites were observed in feces. In conclusion, the major metabolic pathways of pritelivir have been identified with the primary excretion route being renal.