bluuebunny/crossref_metadata_2025_split huggingface dataset:
Impact of calorie intake and weight gain after Norwood procedure on the outcome of stage II palliation
Authors: Staehler Helena , Schaeffer Thibault , Ruf Bettina , Heinisch Paul Philipp , Di Padua Chiara , Burri Melchior , Piber Nicole , Hager Alfred , Ewert Peter , Hörer Jürgen , Ono Masamichi 
Published: November 2023

AbstractBackground:This study aimed to assess the impact of caloric intake and weight-for-age-Z-score after the Norwood procedure on the outcome of bidirectional cavopulmonary shunt.Methods:A total of 153 neonates who underwent the Norwood procedure between 2012 and 2020 were surveyed. Postoperative daily caloric intake and weight-for-age-Z-score up to five months were calculated, and their impact on outcome after bidirectional cavopulmonary shunt was analysed.Results:Median age and weight at the Norwood procedure were 9 days and 3.2 kg, respectively. Modified Blalock-Taussig shunt was used in 95 patients and right ventricle to pulmonary artery conduit in 58. Postoperatively, total caloric intake gradually increased, whereas weight-for-age-Z-score constantly decreased. Early and inter-stage mortality before stage II correlated with low caloric intake. Older age (p = 0.023) at Norwood, lower weight (p < 0.001) at Norwood, and longer intubation (p = 0.004) were correlated with low weight-for-age-Z-score (< –3.0) at 2 months of age. Patients with weight-for-age-Z-score < –3.0 at 2 months of age had lower survival after stage II compared to those with weight-for-age-Z-score of –3.0 or more (85.3 versus 92.9% at 3 years after stage II, p = 0.017). There was no difference between inter-stage weight gain and survival after bidirectional cavopulmonary shunt between the shunt types.Conclusion:Weight-for-age-Z-score decreased continuously throughout the first 5 months after the Norwood procedure. Age and weight at Norwood and intubation time were associated with weight gain. Inter-stage low weight gain (Z-score < –3) was a risk for survival after stage II.
Physical and physiological pathways of off-target triclopyr movement and associated non-target injury following basal bark application
Authors: Oberweger Conrad A. , Enloe Stephen F. , Wilson P. Chris , Prince Candice M. , Sperry Benjamin P. , Hinz Francisca O. 
Published: November 2023

AbstractBasal bark treatment with triclopyr butoxyethyl ester is used to control woody invasive plants, including Brazilian peppertree (Schinus terebinthifolia Raddi). However, the ester formulation cannot be applied where standing water is present, which includes wetlands where S. terebinthifolia is found. In 2009, a low-volatile acid formulation of triclopyr was labeled for use in aquatic sites, which allows for basal bark applications when standing water is present. This formulation may have utility for controlling woody plants in standing water. However, anecdotal observations of injury to non-target plants following applications during periods of inundation have been reported. To address this, mesocosm studies were conducted to assess non-target injury through triclopyr root exudation or release from the surface of treated stems via flooding. Mesocosms contained S. terebinthifolia as the treated target, while sugarberry (Celtis laevigata Willd.), buttonbush (Cephalanthus occidentalis L.), and red maple (Acer rubrum L.) were included as non-targets. In the first study, the pathway of root exudation for non-target injury following triclopyr (34 g L−1) basal bark application was isolated with activated charcoal placed at the soil surface. In the second study, mesocosms were flooded to assess triclopyr release from the surface of treated stems and subsequent non-target injury. Defoliation of non-target species posttreatment was ≤8%, and triclopyr was detected at ≤5 µg L−1 in mesocosm wells when activated charcoal was present. Posttreatment non-target defoliation up to 92%, coupled with triclopyr concentrations in surface waters and wells as high as 4,637 µg L−1, indicated triclopyr movement as a result of flooding. Additionally, triclopyr non-target injury from soil activity independent of flooding was observed. These findings provide limited evidence of triclopyr root exudation but considerable evidence of triclopyr release during flooding following basal bark treatment and support a cautionary approach to basal bark application when standing water is present.
Warum prokrastinieren Promovierende?
Authors: Gross Samuel Henryk , Hansen Miriam 
Published: November 2023

Zusammenfassung: Die meisten Fragebögen in der Prokrastinationsforschung erfassen das Ausmaß an Prokrastination, jedoch nicht die Gründe, warum man prokrastiniert. Patrzek et al. (2014 ) entwickelten diesbezüglich den Fragebogen zu den Gründen akademischer Prokrastination (FGAP), welcher jedoch bisher nur für Studierende validiert ist. Ziel der vorliegenden Studie war die Ergänzung des Fragebogens um promovierendenspezifische Gründe auf Basis einer Fokusgruppe sowie die Validierung des Fragebogens für eine Promovierendenstichprobe. Anhand der Daten von 401 Promovierenden wurden unterschiedliche Faktorenstrukturen mit Hilfe von exploratorischen Strukturgleichungsmodellen (ESEM) gegeneinander getestet. Hierbei zeigte sich, dass das ursprünglich gefundene 13-Faktoren-Modell des FGAP auch in der Promovierendenstichprobe zu einem guten Modell-Fit führt. Für den Fragebogen mit den promovierendenspezfisischen Ergänzungen, dem FGAP für Promovierende (FGAP-P), zeigte ein 15-Faktoren-Modell mit den zwei neuen Skalen Feedback und Deadlines sowie Andere Aufgaben einen guten Modell-Fit. Darüber hinaus zeigt ein hierarchisches Modell, welches fünf theoretisch hergeleitete Faktoren höherer Ordnung (studienbezogene Kompetenzen, persönlichkeitsbezogene Variablen, Überzeugungen, Aufgabenmerkmale, universitäre Rahmenbedingungen) beinhaltet, einen akzeptablen Modell-Fit. Der FGAP-P zeigt für die Promovierendenstichprobe gute Reliabilitäten sowie zufriedenstellende Validitäten. Somit kann der FGAP-P zur Erhebung von Gründen akademischer Prokrastination in Forschung und Beratungspraxis bei Promovierenden verwendet werden.
Geometric Calibration of the ESA Mars Express Orbiter High Resolution Stereo Camera
Authors: Li D. , Jiang Y. , Li J. , Zhang G. , Wei S. , Liu W. 
Published: November 2023

AbstractThe high‐resolution stereo camera mounted on the Mars Express (MEX) spacecraft of the European Space Agency is specifically designed for planetary photogrammetry and mapping missions. High‐precision geometric calibration is required to maintain the geometric quality of satellite imaging. This study aimed to develop a Martian geometric calibration model based on the detector look angle and offset matrix to compensate for systematic errors caused by the camera system parameters, Doppler shift measurements, and other parameters of the interior and exterior orientation during positioning. Moreover, the difficulty in identifying high‐precision geometric ground control points from extra‐terrestrial imagery was addressed by proposing an iterative Mars Orbiter Laser Altimeter extraction algorithm based on the similarity measure of terrain relief. Using this algorithm, constraint conditions were established, and a calibration model was introduced to achieve in‐orbit geometric calibration of the MEX satellite. The proposed method is effective in reducing the distortion of the camera in calibration images from 12 pixels to <1 pixel, both before and after calibration. Moreover, the plane accuracy of validation images improved from approximately 900 to 200 m, while elevation accuracy improved from 500 to 100 m, verifying the effectiveness of the proposed method.
Mantle Deformation Processes During the Rift‐To‐Drift Transition at Magma‐Poor Margins
Authors: Montiel Nicholas J. , Masini Emmanuel , Lavier Luc , Müntener Othmar , Calassou Sylvain 
Published: November 2023

AbstractThe rift‐to‐drift transition at rifted margins is an area of active investigation due to an incomplete understanding of the spatial and temporal evolution of physical and chemical processes at the ocean‐continent transition (OCT). Deep structures that characterize modern OCTs are often difficult to identify by seismic observations, while terrestrial exposures are preserved in fragments separated by tectonic discontinuities. Numerical modeling is a powerful method for contextualizing physical processes and observations relevant to rifted margin evolution. We synthesize results from geological observations of fossil OCTs preserved in ophiolites, a recent seismic experiment on the Ivorian margin, and numerical modeling to characterize mantle deformation and melt production for magma‐poor margins. Across varied surface heat fluxes, mantle potential temperatures, and extension rates, our model results show homologies with geological observations. We propose that the development of large shear zones in the mantle, melt infiltration, grain size reduction, and anastomosing detachment faults control the structure of OCTs. We also infer that a hot, upwelling, melt‐rich asthenosphere is an important control on the local stress environment. During the exhumation phase, continentward‐dipping shear zones couple with seaward‐dipping detachment faults to exhume the subcontinental and formerly asthenospheric mantle. The mantle forms core‐complex‐like domes of peridotite at or near the surface. The faults that exhume these peridotite bodies are largely anastomosing and exhibit magmatic accretion in their footwalls. A combination of magmatic accretion and volcanic activity derived from the shallow melt region constructs the oceanic lithosphere in the footwalls of the out‐of‐sequence continentward‐dipping detachment faults in the oceanic crust and subcontinental mantle.
Evidence for the Presence of Thin and Heterogenous Dust Deposits on Ryugu's Boulders From Hayabusa2 MARA and Sample Data
Authors: Hamm M. , Hamilton V. E. , Goodrich C. A. 
Published: November 2023

AbstractMiddle infrared spectral results obtained in‐situ by the Hayabusa2 MARA instrument are generally in‐line with previous results and a new comparison with sample C0137 returned from asteroid (162173) Ryugu, being similar to an aqueously altered CI1 chondrite. The mid‐IR spectrum of the boulder on Ryugu measured by MARA is shallower around 9 μm compared to the laboratory spectrum of C0137. Here we show that discontinuous, fine dust deposits can partially explain the differences in the spectral data and remain in agreement with the temperature observations of the boulder by MARA if an opaque dust layer covers less than 3% of the field of view. Such a presence of dust covering a low porosity boulder was discounted by previous analysis of the mid‐infrared MARA data which did not consider a highly porous boulder as we do here.
Asymmetry of the Antarctic Oscillation in Austral Autumn
Authors: Tang Yuheng , Duan Anmin 
Published: November 2023

AbstractThe annular structure of Antarctic oscillation (AAO) is a research hotpot, but its asymmetry receives less attention. In this paper, the self‐organizing map method is employed to cluster the AAO patterns into symmetric and asymmetric modes in austral autumn. The asymmetry is mainly reflected in the Pacific‐Atlantic sector, and the AAO evolves toward asymmetric positive polarity, with the most pronounced asymmetry in May. Originating from near Australia, the asymmetry indicates a zonal wave train in the Pacific‐Atlantic sector. Both modeled and observed results demonstrate that the sea surface temperature anomaly in the equatorial western Pacific stimulates a local meridional circulation anomaly and induces anomalous Rossby wave sources near Australia subsequently. An anomalous wave train propagating toward the Antarctic Peninsula is formed, and the associated geopotential anomaly enhances the asymmetry of AAO. Asymmetric AAO is conducive to the Antarctic dipole, which modulates the air temperature and sea ice anomalies around Antarctica.
Enhanced Upper Ocean Warming Projected by the Eddy‐Resolving Community Earth System Model
Authors: Xu Gaopeng , Chang Ping , Small Justin , Danabasoglu Gokhan , Yeager Stephen , Ramachandran Sanjiv , Zhang Qiuying 
Published: November 2023

AbstractOcean warming is a key factor impacting future changes in climate. Here we investigate vertical structure changes in globally averaged ocean heat content (OHC) in high‐ (HR) and low‐resolution (LR) future climate simulations with the Community Earth System Model (CESM). Compared with observation‐based estimates, the simulated OHC anomalies in the upper 700 and 2,000 m during 1960–2020 are more realistic in CESM‐HR than ‐LR. Under RCP8.5 scenario, the net surface heat into the ocean is very similar in CESM‐HR and ‐LR. However, CESM‐HR has a larger increase in OHC in the upper 250 m compared to CESM‐LR, but a smaller increase below 250 m. This difference can be traced to differences in eddy‐induced vertical heat transport between CESM‐HR and ‐LR in the historical period. Moreover, our results suggest that with the same heat input, upper‐ocean warming is likely to be underestimated by most non‐eddy‐resolving climate models.
Imaging the Crustal and Upper Mantle Structure of the North Anatolian Fault: A Transmission Matrix Framework for Local Adaptive Focusing
Authors: Touma Rita , Le Ber Arthur , Campillo Michel , Aubry Alexandre 
Published: November 2023

AbstractImaging the structure of major fault zones is essential for our understanding of crustal deformations and their implications on seismic hazards. Investigating such complex regions presents several issues, including the variation of seismic velocity due to the diversity of geological units and the cumulative damage caused by earthquakes. Conventional migration techniques are in general strongly sensitive to the available velocity model. Here we apply a passive matrix imaging approach which is robust to the mismatch between this model and the real seismic velocity distribution. This method relies on the cross‐correlation of ambient noise recorded by a geophone array. The resulting set of impulse responses form a reflection matrix that contains all the information about the subsurface. In particular, the reflected body waves can be leveraged to: (a) determine the transmission matrix between the Earth's surface and any point in the subsurface; (b) build a confocal image of the subsurface reflectivity with a transverse resolution only limited by diffraction. As a study case, we consider seismic noise (0.1–0.5 Hz) recorded by the Dense Array for Northern Anatolia that consists of 73 stations deployed for 18 months in the region of the 1999 Izmit earthquake. Passive matrix imaging reveals the scattering structure of the crust and upper mantle around the North Anatolian Fault zone over a depth range of 60 km. The results show that most of the scattering is associated with the Northern branch that passes throughout the crust and penetrates into the upper mantle.
Weakness of the Indian Lower Crust Beneath the Himalaya Inferred From Postseismic Deformation of the 2015 Mw 7.8 Gorkha Earthquake
Authors: Zhang Jian , Hu Yan , Zhao Bin , Chen Yunguo 
Published: November 2023

AbstractThe 2015 Mw 7.8 Gorkha (Nepal) earthquake induced prolonged postseismic deformation extending northward beyond the Yarlung Zangbo Suture, which provides unique opportunities to better understand the lithospheric rheology in Himalaya and southern Tibet. Here, we used the first 5‐year Global Positioning System observations to study the main postseismic processes following this event, including viscoelastic relaxation and afterslip, based on a three‐dimensional finite element model. We considered a realistic geometry of the underthrusting Indian plate according to various geophysical images. We found that the models with a uniform elastic Indian lower crust fail to fit the vertical displacements. A heterogeneous Indian lower crust with the transition from elastic (high‐viscosity) to low‐viscosity approximately under the Main Central Thrust is required to reproduce the observed postseismic uplift between China‐Nepal border and Peiku Lake, indicating the weakness of the Indian lower crust from the Lesser to High Himalaya. The afterslip simulated using a weak shear zone takes place in the adjacent area downdip of the rupture zone. The preferred model suggested that viscosities of the Tibetan lower crust, weakened Indian lower crust, and shear zone are 3 × 1018, 1019, and 4 × 1018 Pa s, respectively. The viscosity of the underthrusting Indian upper mantle was roughly estimated to be greater than 1021 Pa s. The model results imply that the near‐field deformation is dominated by both afterslip and viscoelastic relaxation of the weakened Indian lower crust, not only afterslip as suggested by previous studies.
A Three Dimensional Lagrangian Analysis of the Smoke Plume From the 2019/2020 Australian Wildfire Event
Authors: Curbelo Jezabel , Rypina Irina I. 
Published: November 2023

AbstractDuring the 2019/2020 Australian bushfire season, intense wildfires generated a rising plume with a record concentration of smoke in the lower stratosphere. Motivated by this event, we use the atmospheric wind reanalysis model ERA5 to characterize the three dimensional atmospheric transport in the general region of the plume following a dynamical system approach in the Lagrangian framework. Aided by the Finite Time Lyapunov Exponent tool (FTLE), we identify Lagrangian Coherent Structures (LCS) which simplify the three‐dimensional transport description. Different reduced FTLE formulations are compared to study the impact of the vertical velocity and the vertical shear on the movement of the plume. We then consider in detail some of the uncovered LCS that are directly relevant for the evolution of the plume, as well as other LCS that are less relevant for the plume but have interesting geometries, and we show the presence of 3D lobe dynamics at play. Also, we unveil the qualitatively different dynamical fates of the smoke parcels trajectories depending on the region in which they originated. One feature that had a pronounced influence on the evolution of the smoke plume is a synoptic‐scale anticyclone that was formed near the same time as, and close to the region of, intense wildfires. We analyze this anticyclone in detail, including its formation, the entrainment of the smoke plume, and how it maintained coherence for a long time. Transport paths obtained with the inclusion of the buoyancy effects are compared with those obtained considering only the reanalysis velocity.
Three-dimensional label-free morphology of CD8 + T cells as a sepsis biomarker
Authors: Sung MinDong , Kim Jong Hyun , Min Hyun-Seok , Jang Sooyoung , Hong JaeSeong , Choi Bo Kyu , Shin JuHye , Chung Kyung Soo , Park Yu Rang 
Published: November 2023

AbstractSepsis is a dysregulated immune response to infection that leads to organ dysfunction and is associated with a high incidence and mortality rate. The lack of reliable biomarkers for diagnosing and prognosis of sepsis is a major challenge in its management. We aimed to investigate the potential of three-dimensional label-free CD8 + T cell morphology as a biomarker for sepsis. This study included three-time points in the sepsis recovery cohort (N = 8) and healthy controls (N = 20). Morphological features and spatial distribution within cells were compared among the patients’ statuses. We developed a deep learning model to predict the diagnosis and prognosis of sepsis using the internal cell morphology. Correlation between the morphological features and clinical indices were analysed. Cell morphological features and spatial distribution differed significantly between patients with sepsis and healthy controls and between the survival and non-survival groups. The model for predicting the diagnosis and prognosis of sepsis showed an area under the receiver operating characteristic curve of nearly 100% with only a few cells, and a strong correlation between the morphological features and clinical indices was observed. Our study highlights the potential of three-dimensional label-free CD8 + T cell morphology as a promising biomarker for sepsis. This approach is rapid, requires a minimum amount of blood samples, and has the potential to provide valuable information for the early diagnosis and prognosis of sepsis.
Microfluidic magnetic detection system combined with a DNA framework-mediated immune-sandwich assay for rapid and sensitive detection of tumor-derived exosomes
Authors: Qian Qiuling , Wei Yutong , Xu Yi , Zheng Mengmeng , Wang Chenguang , Zhang Shulin , Xie Xiaoming , Ye Chaofeng , Mi Xianqiang 
Published: November 2023

AbstractTumor-derived circulating exosomes (TDEs) are being pursued as informative and noninvasive biomarkers. However, quantitatively detecting TDEs is still challenging. Herein, we constructed a DNA tetrahedral-structured probe (TSP)-mediated microfluidic magnetic detection system (μFMS) to provide a rapid and sensitive platform for analyzing TDEs. CD63 aptamer-modified Fe3O4 magnetic nanoparticles (MNPs) were constructed to form magnetic nano-report probes (MNRs). The microfluidic chips were fabricated from glass functionalized with DNA TSP-modified aldehyde groups and a PDMS layer designed with serpentine microchannels. An induction coil-based magnetic detector was used to measure the magnetic signal. The linear dynamic range of the μFMS system for TDE assays was 1.98 × 103–1.98 × 107 particles/mL with a limit of detection of 1.98 × 103 particles/mL in PBS. There was no significant difference in TDE detection between the simulated serum and PBS, which indicated the feasibility of the constructed μFMS system for TDE analysis in complex biological systems. In terms of cost, reaction time and operation procedure, this μFMS has the potential to be developed as a clinical point-of-care testing tool for cancer diagnosis and therapeutics.
Pyrroloquinoline quinone inhibits PCSK9-NLRP3 mediated pyroptosis of Leydig cells in obese mice
Authors: Wang Jinyuan , Zhang Shun , Hu Linlin , Wang Yan , Liu Ke , Le Jianghua , Tan Yongpeng , Li Tianlong , Xue Haoxuan , Wei Yanhong , Zhong Ou , He Junhui , Zi Dan , Lei Xin , Deng Renhe , Luo Yafei , Tang Masong , Su Mingxuan , Cao Yichang , Liu Qingyou , Tang Zhihan , Lei Xiaocan 
Published: November 2023

AbstractAbnormal lipid metabolism and chronic low-grade inflammation are the main traits of obesity. Especially, the molecular mechanism of concomitant deficiency in steroidogenesis-associated enzymes related to testosterone (T) synthesis of obesity dominated a decline in male fertility is still poorly understood. Here, we found that in vivo, supplementation of pyrroloquinoline quinone (PQQ) efficaciously ameliorated the abnormal lipid metabolism and testicular spermatogenic function from high-fat-diet (HFD)-induced obese mice. Moreover, the transcriptome analysis of the liver and testicular showed that PQQ supplementation not only inhibited the high expression of proprotein convertase subtilisin/Kexin type 9 (PCSK9) but also weakened the NOD-like receptor family pyrin domain containing 3 (NLRP3)-mediated pyroptosis, which both played a negative role in T synthesis of Leydig Cells (LCs). Eventually, the function and the pyroptosis of LCs cultured with palmitic acid in vitro were simultaneously benefited by suppressing the expression of NLRP3 or PCSK9 respectively, as well the parallel effects of PQQ were affirmed. Collectively, our data revealed that PQQ supplementation is a feasible approach to protect T synthesis from PCSK9-NLRP3 crosstalk-induced LCs’ pyroptosis in obese men.