bluuebunny/crossref_metadata_2025_split huggingface dataset:
The complete genome sequence of Neckar River virus confirms it to be a distinct member of the genus Tombusvirus in the family Tombusviridae
Authors: Tran Thi Chi , Maiss Edgar , Rose Hanna 
Published: November 2023

AbstractNeckar River virus (NRV), first isolated from a water sample of the Neckar River (Germany) in the 1980s, was serologically characterized as a novel tombusvirus. In this study, the complete genome sequence was determined, and an infectious full-length cDNA clone was constructed. The genome organization of NRV (DSMZ PV-0270) resembles that of tombusviruses. The genome consists of 4739 nucleotides and contains five open reading frames (ORFs) and one additional putative ORF (pX) in the 3’-terminal region. Phylogenetic analysis and sequence comparisons confirmed NRV to be a member of the species Tombusvirus neckarfluminis in the genus Tombusvirus. The infectious full-length cDNA clone was constructed using Gibson assembly and subsequent infection of Nicotiana benthamiana plants by Rhizobium radiobacter inoculation. The virus derived from the full-length cDNA clone caused symptoms resembling those caused by the wild-type virus, but slightly milder.
6-Pyrazolylpurine and its deaza derivatives as nucleobases for silver(I)-mediated base pairing with pyrimidines
Authors: Escher Daniela , Schäfer Tim , Hebenbrock Marian , Müller Jens 
Published: November 2023

AbstractThe artificial nucleobase 6-pyrazolylpurine (6PP) and its deaza derivatives 1-deaza-6-pyrazolylpurine (1D6PP), 7-deaza-6-pyrazolylpurine (7D6PP), and 1,7-dideaza-6-pyrazolylpurine (1,7D6PP) were investigated with respect to their ability to differentiate between the canonical nucleobases cytosine and thymine by means of silver(I)-mediated base pairing. As shown by temperature-dependent UV spectroscopy and by circular dichroism spectroscopy, 6PP and (to a lesser extent) 7D6PP form stable silver(I)-mediated base pairs with cytosine, but not with thymine. 1D6PP and 1,7D6PP do not engage in the formation of stabilizing silver(I)-mediated base pairs with cytosine or thymine. The different behavior of 1D6PP, 7D6PP, and 1,7D6PP indicates that silver(I) binding occurs via the N1 position of the purine derivative, i.e. via the Watson–Crick face. The data show that 6PP is capable of differentiating between cytosine and thymine, which is potentially relevant in the context of detecting single-nucleotide polymorphisms.
Graphical abstract
New lower bounds on crossing numbers of $$K_{m,n}$$ from semidefinite programming
Authors: Brosch Daniel , C. Polak Sven 
Published: November 2023

AbstractIn this paper, we use semidefinite programming and representation theory to compute new lower bounds on the crossing number of the complete bipartite graph $$K_{m,n}$$

K

m
,
n

, extending a method from de Klerk et al. (SIAM J Discrete Math 20:189–202, 2006) and the subsequent reduction by De Klerk, Pasechnik and Schrijver (Math Prog Ser A and B 109:613–624, 2007). We exploit the full symmetry of the problem using a novel decomposition technique. This results in a full block-diagonalization of the underlying matrix algebra, which we use to improve bounds on several concrete instances. Our results imply that $$\mathop {\textrm{cr}}\limits (K_{10,n}) \ge 4.87057 n^2 - 10n$$

cr

(

K

10
,
n

)

≥
4.87057

n
2

-
10
n

, $$\mathop {\textrm{cr}}\limits (K_{11,n}) \ge 5.99939 n^2-12.5n$$

cr

(

K

11
,
n

)

≥
5.99939

n
2

-
12.5
n

, $$ \mathop {\textrm{cr}}\limits (K_{12,n}) \ge 7.25579 n^2 - 15n$$

cr

(

K

12
,
n

)

≥
7.25579

n
2

-
15
n

, $$\mathop {\textrm{cr}}\limits (K_{13,n}) \ge 8.65675 n^2-18n$$

cr

(

K

13
,
n

)

≥
8.65675

n
2

-
18
n

for all n. The latter three bounds are computed using a new and well-performing relaxation of the original semidefinite programming bound. This new relaxation is obtained by only requiring one small matrix block to be positive semidefinite.
Experimental investigation using demountable steel-concrete composite reduced web section (RWS) connections under cyclic loads
Authors: Almutairi Fahad Falah , Tsavdaridis Konstantinos Daniel , Alonso-Rodriguez Andres , Hajirasouliha Iman 
Published: November 2023

AbstractThis paper presents an experimental study of demountable steel-concrete composite reduced web section (RWS) connections for use in seismic areas. Four composite connection specimens were subjected to sagging and hogging moments to investigate the performance of RWS connections under reversible actions. For such purpose, a single web opening was created near the beam-column joint. Focus was made on the effects of perforation location and composite beam-slab action induced by bolted shear studs within the protected zone. Results indicate that employing RWS connections for seismic retrofit is a viable solution capable of achieving a performance similar to that observed for RBS connections in new buildings. Notably, a Vierendeel Mechanism is formed, allowing for plasticity development in the beam. All RWS connections were capable of achieving an interstory drift larger than 4%, thereby complying with the performance targets set by ANSI/AISC 358-16, ANSI/AISC 341-16 and EC8. Moreover, the deformation of beam-slab shear-transfer bolts was small enough to allow for disassembly after the tests, indicating that the proposed solution could enable reuse and post-earthquake retrofitting.
Aquatic phases have a stronger effect on lotic benthic diatoms than human-induced microhabitat variability
Authors: Kiss Stefánia , Nemes-Kókai Zsuzsanna , Lukács Áron , Bácsi István , T-Krasznai Enikő , Márton Kamilla , B-Béres Viktória 
Published: November 2023

AbstractHere, we studied the influence of changes of aquatic phases (standing and flowing phases) and human-induced habitat variability (natural and artificial) on the composition and diversity of benthic diatom assemblages in a small lowland stream in the Pannonian Ecoregion. Significant differences in composition were hypothesized between phases and habitats. Lower diversity was hypothesized in the flowing phase and in the artificial habitat. In addition, worser ecological status were assumed in the artificial habitat and in the standing phase than in the others. Our results only partially supported our hypotheses. While there was no significant difference in the composition of the assemblages between the natural and concreted habitats, the alteration in flow conditions resulted in a significant change. No significant differences in diversity were found between aquatic phases. In contrast, biodiversity was higher in the artificial habitat than in the natural one. While the anthropogenic impact, i.e., concreted streambed has no significant influence on diatom-based ecological status, values of diatom indices were significantly higher in the flowing phase. Our results highlight that extreme weather events play a major role in shaping diatom assemblages even during a short period, which should be taken into account in water management and nature conservation measures.
What Makes Work “Good” in the Age of Artificial Intelligence (AI)? Islamic Perspectives on AI-Mediated Work Ethics
Authors: Ghaly Mohammed 
Published: November 2023

AbstractArtificial intelligence (AI) technologies are increasingly creeping into the work sphere, thereby gradually questioning and/or disturbing the long-established moral concepts and norms communities have been using to define what makes work good. Each community, and Muslims make no exception in this regard, has to revisit their moral world to provide well-thought frameworks that can engage with the challenging ethical questions raised by the new phenomenon of AI-mediated work. For a systematic analysis of the broad topic of AI-mediated work ethics from an Islamic perspective, this article focuses on presenting an accessible overview of the “moral world” of work in the Islamic tradition. Three main components of this moral world were selected due to their relevance to the AI context, namely (1) Work is inherently good for humans, (2) Practising a religiously permitted profession and (c) Maintaining good relations with involved stakeholders. Each of these three components is addressed in a distinct section, followed by a sub-section highlighting the relevance of the respective component to the particular context of AI-mediated work. The article argues that there are no unsurmountable barriers in the Islamic tradition against the adoption of AI technologies in work sphere. However, important precautions should be considered to ensure that embracing AI will not be at the cost of work-related moral values. The article also highlights how important lessons can be learnt from the positive historical experience of automata that thrived in the Islamic civilization.
Emotion Regulation Predicts Depressive Symptoms in Adolescents: A Prospective Study
Authors: Kökönyei Gyöngyi , Kovács Lilla Nóra , Szabó Judit , Urbán Róbert 
Published: November 2023

AbstractEmotion regulation as a proximal factor has been linked with depressive symptoms. However, studies have mainly focused on a limited number of strategies and have mostly been cross-sectional in design. This is particularly evident when examining the protective effects of adaptive strategies. This study aimed to investigate the prospective relationship between putatively adaptive and maladaptive emotion regulation strategies and depressive symptoms among adolescents. Additionally, a person-oriented approach was applied to identify latent classes of adolescents based on their depressive symptoms and compared these classes in terms of their adaptive and maladaptive strategies. Two waves of data from a prospective study, which included 1371 youth (mean age: 15.66 years; SD = 0.49 years; 55.1% girls), were analysed. The two points of data collection were spaced approximately half a year apart. Depressive symptoms were measured using the Center for Epidemiologic Studies Depression Scale, and putatively adaptive and maladaptive emotion regulation strategies were assessed with the Cognitive Emotion Regulation Questionnaire. Seven strategies (acceptance, positive refocusing, positive reappraisal, putting into perspective, self-blame, rumination, and catastrophizing) were categorised into adaptive and maladaptive factors using exploratory structural equation modeling. After controlling for gender, age, and depressive symptoms at Time 1, both maladaptive and adaptive emotion regulation strategies at Time 1 predicted depressive symptoms at Time 2. Three subgroups emerged based on the intensity of depressive symptoms across the waves: the stable low, stable moderate, and stable high depressive symptom groups. The use of maladaptive emotion regulation strategies (such as rumination, self-blame, and catastrophizing) at Time 1 was more pronounced in the stable moderate and high symptom groups compared to the stable low depressive symptom group. The comparable prospective associations between putatively adaptive and maladaptive strategies with symptoms suggest the need to identify factors that may mitigate the negative impact of maladaptive emotion regulation and/or promote adaptive emotion regulation to buffer the effects of everyday stressors.
The 2 December 2020 MW 4.6, Kallithea (Viotia), central Greece earthquake: a very shallow damaging rupture detected by InSAR and its role in strain accommodation by neotectonic normal faults
Authors: Valkaniotis Sotiris , De Novellis Vincenzo , Ganas Athanassios , Sansosti Eugenio , Convertito Vincenzo , Briole Pierre , Tsironi Varvara , Karasante Ilektra , Karamitros Ioannis 
Published: November 2023

AbstractOn 2 December 2020 10:54 UTC a shallow earthquake of MW (NOA) = 4.6 occurred near the village of Kallithea (to the east of Thiva), central Greece, which, despite its modest size, was locally damaging. Using InSAR and GNSS data, we mapped a permanent change on the ground surface, i.e., a subsidence of 7 cm. Our geodetic inversion modelling indicates that the rupture occurred on a WNW–ESE striking, SSW-dipping normal fault, with a dip-angle of ~ 54°. The maximum slip value was 0.35 m, which was reached at a depth of about 1100 m. The analysis of broadband seismological data also provided kinematic source parameters such as moment magnitude MW = 4.6 (± 0.1), rupture area 6.3 km2 and mean slip 0.16 m, which agree with the values obtained from the geodetic model. The effects of the earthquake were disproportionate to its moderate magnitude, probably due to its unusually shallow depth (slip centroid at 1.1 km) and the high efficiency of the earthquake (radiation efficiency $$\eta$$
η
= 0.62). The geodetic data inversion also indicates that within the uncertainty limits of the technique, three scenarios are possible (a) the earthquake responsible for the mapped surface deformation may have occurred on a ~ 2-km long, blind normal fault different from the well-known active Kallithea normal fault or (b) could have occurred along a secondary fault that branches off the Kallithea fault or (c) it may have occurred along the Kallithea fault itself, but with its geometrical configuration could not be modelled with available data. We have also concluded that with a high dip-angle Kallithea Fault forward model it is not possible to fit the geodetic data. The rupture initiated at a very shallow depth (1.1 km) and it could not propagate deeper possibly because of a structural barrier down-dip. The 2020 event near Kallithea highlighted the structural complexity in this region of the Asopos Rift valley as the reactivation of the WNW–ESE structures indicates their significant role in strain accommodation and that they still represent a seismic hazard for this region.
Physical activity in liver transplant recipients: a large multicenter study
Authors: Gitto Stefano , Golfieri Lucia , Gabrielli Filippo , Falcini Margherita , Sofi Francesco , Tamè Maria Rosa , De Maria Nicola , Marzi Luca , Mega Andrea , Valente Giovanna , Borghi Alberto , Forte Paolo , Cescon Matteo , Di Benedetto Fabrizio , Andreone Pietro , Petranelli Marco , Morelli Maria Cristina , De Simone Paolo , Lau Chloe , Stefani Laura , Vizzutti Francesco , Chiesi Francesca , Marra Fabio ,   MEDITRA Research Group, Vitale Giovanni , Bisonti Giacomo , Schepis Filippo , Villa Erica , Piai Guido , Foschi Francesco Giuseppe , Magistri Paolo , Carrai Paola , Petruccelli Stefania , Corsi Marco , Falconi Edoardo , Palazzo Roberto 
Published: November 2023

Abstract
Aim
Healthy lifestyle and appropriate diet are of critical importance after liver transplant (LT). We provided an analysis of the main patterns of physical activity and found factors associated with physical activity itself.

Methods
Clinically stable LT recipients were enrolled between June and September 2021. Patients completed a composite questionnaire about physical activity, adherence to Mediterranean Diet (MD), quality of life (QoL), and employment. Correlations were analysed using the Pearson coefficients while different subgroups were compared by t-test for independent samples or ANOVAs. Multivariable logistic regression analysis was conducted to find predictors of inactivity.

Results
We enrolled 511 subjects (71% males, mean age 63 ± 10.8 years). One hundred and ninety-three patients reported high level of physical activity, 197 a minimal activity and 121 declared insufficient activity. Among these latter, 29 subjects were totally inactive. Considering the 482 LT recipients performing some kind of physical activity, almost all reported a low-quality, non-structured activity. At multivariate analysis, time from LT (odds ratio 0.94, 95% CI 0.89–0.99, p = 0.017), sedentary lifestyle (odds ratio 0.99, 95% CI 0.19–0.81, p = 0.012), low adherence to MD (odds ratio 1.22, 95% CI 1.01–1.48, p = 0.049), and low level of QoL (physical dimension) (odds ratio 1.13, 95% CI 1.08–1.17, p < 0.001), were independently associated with total inactivity.

Conclusion
A large portion of LT recipients report an insufficient level of physical activity or are wholly inactive. Inactivity increases with time from LT and was strongly associated with suboptimal diet and low QoL.
Medical care costs according to the stage and subtype of breast cancer in a municipal setting: a case study of Hachioji City, Japan
Authors: Nishikawa Yoshitaka , Agatsuma Nobukazu , Utsumi Takahiro , Funakoshi Taro , Mori Yukiko , Nakamura Yuki , Hoshino Nobuaki , Horimatsu Takahiro , Saito Takumi , Kashihara Soichiro , Fukuyoshi Jun , Goto Rei , Toi Masakazu , Takahashi Yoshimitsu , Nakayama Takeo 
Published: November 2023

Abstract
Background
It is important to assess whether the early detection of breast cancer affects medical care costs. However, research remains scant on the actual medical care costs associated with breast cancer treatment in Japan. This study aimed to determine the medical care costs of breast cancer treatment based on its stage using national health insurance claims data.

Methods
This was an observational study including patients with breast cancer who had undergone breast cancer treatment, as defined by the disease name and related treatment codes. Between August 2013 and June 2016, patients who underwent surgical treatment without axillary lymph node dissection and other radical treatment were classified as the curable group, while those who underwent palliative treatment were classified as the non-curable group. Patients were further stratified by subtype. The total and treatment-specific medical care costs for the five years were calculated using the national health insurance claims data of Hachioji City between August 2013 and May 2021.

Results
The mean total medical care costs for the curable and non-curable groups for the 5 years were JPY 3958 thousand (standard deviation 2664) and JPY 8289 thousand (8482), respectively. The mean medical care costs for specific breast cancer treatment for the curable and non-curable groups were JPY 1142 (728) thousand and JPY 3651 thousand (5337), respectively. Further, human epidermal growth factor receptor 2 + , Hormone + patients had the highest mean cost over the 5 years.

Conclusions
The results suggest that the early detection of breast cancer may reduce medical care costs at the patient level.
Follicular DNA Damage and Pesticide Exposure Among Latinx Children in Rural and Urban Communities
Authors: Lepetit Cassandra , Gaber Mohamed , Zhou Ke , Chen Haiying , Holmes Julia , Summers Phillip , Anderson Kim A. , Scott Richard P. , Pope Carey N. , Hester Kirstin , Laurienti Paul J. , Quandt Sara A. , Arcury Thomas A. , Vidi Pierre-Alexandre 
Published: November 2023

AbstractThe intersectional risks of children in United States immigrant communities include environmental exposures. Pesticide exposures and their biological outcomes are not well characterized in this population group. We assessed pesticide exposure and related these exposures to DNA double-strand breaks (DSBs) in Latinx children from rural, farmworker families (FW; N = 30) and from urban, non-farmworker families (NFW; N = 15) living in North Carolina. DSBs were quantified in hair follicular cells by immunostaining of 53BP1, and exposure to 72 pesticides and pesticide degradation products were determined using silicone wristbands. Cholinesterase activity was measured in blood samples. DSB frequencies were higher in FW compared to NFW children. Seasonal effects were detected in the FW group, with highest DNA damage levels in April–June and lowest levels in October–November. Acetylcholinesterase depression had the same seasonality and correlated with follicular DNA damage. Organophosphate pesticides were more frequently detected in FW than in NFW children. Participants with organophosphate detections had increased follicular DNA damage compared to participants without organophosphate detection. Follicular DNA damage did not correlate with organochlorine or pyrethroid detections and was not associated with the total number of pesticides detected in the wristbands. These results point to rural disparities in pesticide exposures and their outcomes in children from vulnerable immigrant communities. They suggest that among the different classes of pesticides, organophosphates have the strongest genotoxic effects. Assessing pesticide exposures and their consequences at the individual level is key to environmental surveillance programs. To this end, the minimally invasive combined approach used here is particularly well suited for children.
Significant relationship between musculoaponeurotic attachment of the abdominal and thigh adductor muscles to the pubis: implications for the diagnosis of groin pain
Authors: Tharnmanularp Suthasinee , Muro Satoru , Nimura Akimoto , Ibara Takuya , Akita Keiichi 
Published: November 2023

AbstractGroin pain is prevalent in orthopedic and sports medicine, causing reduced mobility and limiting sports activity. To effectively manage groin pain, understanding the detailed anatomy of supporting muscles is crucial. This study aimed to investigate the musculoaponeurotic attachments on the pubis and the relationship among intramuscular aponeuroses of abdominal and thigh adductor musculatures. Macroscopic analyses were performed in 10 pelvic halves. The bone morphology of the pubis was assessed in two pelvic halves using microcomputed tomography. Histological investigations were conducted in two pelvic halves. The external oblique aponeurosis extended to the adductor longus aponeurosis, forming conjoined aponeurosis, which attached to a small impression distal to the pubic crest. The gracilis aponeurosis merges with the adductor brevis aponeurosis and is attached to the proximal part of the inferior pubic ramus. The rectus abdominis and pyramidalis aponeuroses were attached to the pubic crest and intermingled with the gracilis-adductor brevis aponeurosis, forming bilateral conjoined aponeurosis, which attached to a broad area covering the anteroinferior surface of the pubis. Histologically, these two areas of conjoined aponeuroses were attached to the pubis via the fibrocartilage enthesis. Microcomputed tomography revealed two distinctive bone morphologies, a small impression and an elongated osseous prominence on pubis, corresponded to the two areas of conjoined aponeuroses. This study demonstrated close relationships between the aponeurotic attachment of the external oblique and adductor longus, and between the rectus abdominis, pyramidalis, gracilis, and adductor brevis. The findings of aponeurotic complexes would aid in diagnostic and surgical approaches for athletic groin pain.