bluuebunny/crossref_metadata_2025_split huggingface dataset:
PANI/Zn‐Cu ferrite polymer composites as free‐standing high dielectric materials
Authors: Kumar Tamilarasi , Paul Raj Aji Udhaya , Muthukrishnan Meena , Thiagamani Senthil Muthu Kumar , Hashem Mohamed , Mukarram Shaikh Ayaz 
Published: January 2024

AbstractIn a wide range of applications, from consumer electronics to cutting‐edge industrial and scientific equipment, high dielectric permittivity (ε′) polymers are crucial for maximizing the performance and efficiency of electrical and electronic systems. Researchers strive to create and perfect these materials to meet the changing demands of modern technology. It is generally known that freestanding bare polymers cannot achieve high dielectric values; however, the mixing of multiple materials that are distinct is an effective technique for developing high dielectric hybrids. Polymer‐based nanoarchitectures are particularly beneficial for use in the storage of energy due to characteristics such as excellent mechanical strength, noncorrosive nature, lightweight, affordability, versatility, thermal and electrical shielding. The primary aim of this investigation is to prepare copper ferrite, zinc ferrite, and copper0.5 zinc0.5 ferrite (CuFe2O4, ZnFe2O4, and Cu0.5Zn0.5Fe2O4) nanoparticle (NP) via combustion technique using egg albumen as a fuel and these NPs were separately dispersed in polyaniline (PANI) matrix by the method of ex situ polymerization of aniline with an objective to enhance the electrical properties for energy storage and electromagnetic wave applications. Flexible freestanding films were casted via solution casting technique. X‐ray diffractogram of 5 wt.% NP dispersed PANI films confirmed the presence of NPs in the PANI matrix. Scanning electron micrograph images show the homogeneous dispersion of NPs into PANI matrix. Rather than the pure ferrite NPs, mixed ferrite highly enhance the permittivity of PANI films without much increasing its loss factor, the obtained values of ε′ of all the three ferrite added films are higher than polyvinylidene fluoride (PVDF)/(Mn0.2Zr0.2Cu0.2Ca0.2Ni0.2)Fe2O4 nanofiller. In this work notably for 5 wt.% Cu0.5Zn0.5Fe2O4 dispersed film shows the highest value of ε′ (7291) for 100 Hz at 150°C with ultralow loss factor (0.08) which is the key characteristic of an energy storage material. Thus, this present study leads the formation of a cost effective, flexible, high dielectric material, which can be a potential alternate to replace PVDF/(Mn0.2Zr0.2Cu0.2Ca0.2Ni0.2)Fe2O4 and polyvinyl alcohol/Ni0.65Cu0.35Fe2O4 polymer blends for energy storage applications.
Exchangeable disulfide bond containing highly flexible epoxy vitrimers with shape‐memory, self‐healing, and UV shielding attributes
Authors: Dutta Kalyan , Karak Niranjan 
Published: January 2024

AbstractWith the rise in momentous resource wastage and severe environmental pollution, a viable path for sustainability is through the use of reprocessable and recyclable materials like vitrimers. Herein, we demonstrated the synthesis of dynamic disulfide‐containing epoxy resin by condensing an amide derivative of 2,2′‐dithiodibenzoic acid with epichlorohydrin. The aforementioned epoxy resin was cured utilizing the two bio‐based curing agents poly(amido amine) and cystamine to produce three distinct epoxy vitrimers. The use of reactive diluent reduced the generation of volatile organic compounds during the curing process. The existence of disulfide bond and aliphatic moiety in the epoxy vitrimers established high elongation at break with good tensile strength. Owing to the dynamic bond, the vitrimers exhibited self‐healing properties with a healing efficiency of 71.48% along with good shape memory abilities. Additionally, the disulfide bond dynamic exchange reaction allowed the polymer chain architecture to topologically reorganize, making them reprocessable and degradable. Moreover, these epoxy vitrimers have the ability to shield ultraviolet radiation as well as inhibits oxidation, and have good chemical resistance properties. The investigated epoxy thermoset thus provides a lot of potential for application as a durable thin film material.
Incidence and survival for childhood cancer by endorsed non‐stage prognostic indicators in Australia
Authors: Youlden Danny R. , Gupta Sumit , Frazier A. Lindsay , Moore Andrew S. , Gottardo Nicholas G. , Aitken Joanne F. 
Published: January 2024

AbstractBackgroundAn international expert panel recently recommended 15 ‘non‐stage prognostic indicators’ (NSPIs) across eight childhood cancers, classified as essential or additional, for collection in population‐based cancer registries. We aimed to describe the incidence distribution and survival of each of these NSPIs.ProceduresCases were extracted from the Australian Childhood Cancer Registry. The study cohort (n = 4187) comprised all children aged under 15 years diagnosed with an eligible cancer between 2010 and 2018, with follow‐up until 31 December 2020. NSPI data were collected directly from each patient's medical records. Differences in 5‐year relative survival were assessed using multivariable flexible parametric models, adjusted for sex and age group at diagnosis.ResultsThe availability of data varied, exceeding 85% for all essential NSPIs apart from histologic subtype for Wilms tumours (69%) and lineage for acute lymphoblastic leukaemia (78%). Information on additional NSPIs tended to be recorded less often, particularly cytogenetic subtype for non‐alveolar rhabdomyosarcoma (28%) and astrocytoma (4%). Eight NSPIs exhibited a significant difference in survival, with the largest disparity occurring among children with astrocytoma according to tumour grade (5‐year relative survival of 18% for grade IV disease compared with 99% for grade I disease; p < .001).ConclusionsOur findings demonstrate that most of the recommended NSPIs can be retrieved from medical records in Australia in recent years, allowing the capability of assessing survival within patient subgroups of clinical interest. Reporting of NSPI data has the capability to inform local and global understanding of population‐level disparities in childhood cancer survival.
Ultrasound‐assisted ethanol/K2HPO4 aqueous two‐phase extraction of polysaccharides from Plantago asiatica L. seeds: Process optimization, physicochemical properties, and antioxidant activity
Authors: Zhang Hua , Zhu Wenbin 
Published: January 2024

AbstractIntroductionThe seeds of Plantago asiatica L., a folk herb, are rich in polysaccharides that possess antioxidant, antidiabetic, and anti‐inflammatory properties. Polysaccharides with lower molecular weights generally exhibit higher biological activity, so a method to efficiently extract low‐molecular‐weight polysaccharides from P. asiatica L. seeds (PLPs) is needed.ObjectivesThe aim was to establish an efficient method for extracting polysaccharides from P. asiatica L. seeds while preserving their activity.Materials and MethodsResponse surface methodology was applied to determine the optimal polysaccharide extraction conditions. Subsequently, the extracted polysaccharides were characterized to determine their monosaccharide composition, physicochemical properties, and molecular weight. Their antioxidant activity was evaluated by measuring their ability to scavenge DPPH and ABTS free radicals.ResultsAn extraction yield of 9.17% was achieved under an ethanol concentration of 18.0% (w/w), a K2HPO4 concentration of 27.8% (w/w), a solvent‐to‐material ratio of 30:1 (mL/g), an ultrasound power of 203 W, and an extraction time of 39 min. Structural analyses indicated that this method might cause physicochemical changes in the conformation of PLPs and induce the degradation of PLP side chains but not the backbone.The antioxidant assay results showed that the DPPH and ABTS radical scavenging rates of PLPs were 48.3% and 49.2%, respectively, while in the control group the radical scavenging rates were 35.5% and 37.1%, respectively.ConclusionThe established method for extracting polysaccharides from P. asiatica L. seeds is efficient and reliable. The polysaccharides could be used as an important resource with antioxidant activity.
Two‐dimensional β‐ketoenamine linked azo covalent organic frameworks as heterogeneous catalysts for photo‐induced RCMP
Authors: Ding Qiuyu , Lu Zhen , Zhao Rui , Xiao Longqiang , Hou Linxi 
Published: January 2024

AbstractPhoto‐induced reversible complexation‐mediated polymerization (RCMP) is a green and economical method to prepare polymers with precise molecular weights, narrow molecular weight distributions and functionally active chain ends. Covalent organic frameworks (COFs) are a promising heterogeneous photocatalyst for mediating RCMP due to their adjustable structure, band gap, and porosity. In this work, 1,3,5‐triformylphloroglucinol (Tp) and p‐azoaniline (Azo) were selected to construct 2D β‐ketoenamine linked Tp‐Azo‐COF as a heterogeneous photocatalyst to trigger RCMP under white light irradiation. A series of polymers with controllable molecular weight and narrow molecular weight distribution were successfully prepared by using Tp‐Azo‐COF as photocatalysis. On/off light experiments confirmed the good spatiotemporal control feature, and chain expansion experiments demonstrated the high “activity” of polymer chain ends. Furthermore, the mechanistic research elucidated that electron transfer between Tp‐Azo‐COF and initiator occurred, allowing the formation of reactive radicals to mediate RCMP. Density functional theory calculations revealed that the coordination of iodine on the initiator to catalyst obviously reduced the bond dissociation energy, leading to enhance in the polymerization rate. This work provides a platform for constructing heterogeneous photocatalysts with more efficient and stable to mediate RCMP.
Rehabilitation in children with home invasive mechanical ventilation
Authors: Genç Aysun , Sonel Tur Birkan 
Published: January 2024

AbstractChildren with home invasive mechanical ventilation need special health care and rehabilitation services due to complications caused by both the pulmonary system and physical inactivity. Children who are dependent on invasive mechanical ventilators due to breathing difficulties and lung problems can benefit from rehabilitation programs. Rehabilitation requires a close relationship between the child, parents and/or caregivers, and healthcare professionals. The main goal of rehabilitation is to improve breathing, lung function and overall quality of life. In this review, although full standard approaches have not been determined yet, rehabilitation approaches for children dependent on home‐type invasive mechanical ventilator will be discussed.
Tandem repeats of highly bioluminescent NanoLuc are refolded noncanonically by the Hsp70 machinery
Authors: Apostolidou Dimitra , Zhang Pan , Pandya Devanshi , Bock Kaden , Liu Qinglian , Yang Weitao , Marszalek Piotr E. 
Published: January 2024

AbstractChaperones are a large family of proteins crucial for maintaining cellular protein homeostasis. One such chaperone is the 70 kDa heat shock protein (Hsp70), which plays a crucial role in protein (re)folding, stability, functionality, and translocation. While the key events in the Hsp70 chaperone cycle are well established, a relatively small number of distinct substrates were repetitively investigated. This is despite Hsp70 engaging with a plethora of cellular proteins of various structural properties and folding pathways. Here we analyzed novel Hsp70 substrates, based on tandem repeats of NanoLuc (Nluc), a small and highly bioluminescent protein with unique structural characteristics. In previous mechanical unfolding and refolding studies, we have identified interesting misfolding propensities of these Nluc‐based tandem repeats. In this study, we further investigate these properties through in vitro bulk experiments. Similar to monomeric Nluc, engineered Nluc dyads and triads proved to be highly bioluminescent. Using the bioluminescence signal as the proxy for their structural integrity, we determined that heat‐denatured Nluc dyads and triads can be efficiently refolded by the E. coli Hsp70 chaperone system, which comprises DnaK, DnaJ, and GrpE. In contrast to previous studies with other substrates, we observed that Nluc repeats can be efficiently refolded by DnaK and DnaJ, even in the absence of GrpE co‐chaperone. Taken together, our study offers a new powerful substrate for chaperone research and raises intriguing questions about the Hsp70 mechanisms, particularly in the context of structurally diverse proteins.
Dipicolinate Oxovanadium(IV) Complexes – Well‐Defined, Universal Precatalysts for Ethylene Polymerization and Polar Monomers Oligomerization
Authors: Drzeżdżon Joanna , Białek Marzena , Parnicka Patrycja , Zaleska‐Medynska Adriana 
Published: January 2024

AbstractIn the field of polymers and organometallic chemistry, a significant gap is apparent in the area of research on well‐defined metal complexes targeted for using in catalysis leading to olefinic oligomers and polymers. Here, we report on the use in these processes the dipicolinate oxovanadium(IV) complexes, without and with auxiliary ligands, i. e. 1,10‐phenanthroline and 2,2’‐bipyridine. The investigated complexes turned out to be versatile precatalysts. After reaction with appropriate activator, they exhibited 11 times higher a catalytic activity than reference vanadium(IV) complexes with salen ligands – so far, precatalysts from a group of vanadium(IV) complexes with the highest known catalytic activity for polymerization of ethylene. In the case of the oligomerization of polar monomers (2‐chloro‐2‐propen‐1‐ol and 3‐buten‐2‐ol) the complexes described in this report have a catalytic activity (very high) similar to vanadium(IV) complexes known in the literature.
Synthesis of New Isoindolines Derived from L‐Α‐Amino Acids and their Selectivity on Cancer Cell Lines
Authors: Mancilla Percino Teresa , Hernández Rodríguez Maricarmen , Mera Jiménez Elvia 
Published: January 2024

AbstractIsoindolines are essential from the point of view of synthesis and their biological properties, so this work is focused on the synthesis of new isoindolines derived from the following L‐α‐amino acids, aspartic acid (1), arginine (2), glutamic acid (3‐5), serine (6), and lysine (7). All compounds were characterized by 1H and 13C NMR, infrared, and high‐resolution mass spectrometry. In addition, the synthesized compounds were screened to investigate their antiproliferative activities against five human cancer cell lines, A549, U373, MDA‐MB‐231, MCF‐7, and HeLa, as well as on primary cell culture healthy, MGC, EC, and Vero cells lines. All tested compounds exhibited activity against cancer cell lines at mM concentrations. Notably, compounds 6 derived from Ser, and 7 derived from Lys exhibited remarkable effects on the A549 and U373. The IC50 values for these compounds were determined to be 0.001 and 0.007 mM, respectively. These findings indicate a significantly higher potency of compounds 6 and 7 than the other tested compounds. Among the tested compounds, only compound 5 displayed significant cytotoxic activity against the Vero cell line.
Doping‐Induced Surface and Grain Boundary Effects in Ni‐Rich Layered Cathode Materials
Authors: Kuo Liang‐Yin , Roitzheim Christoph , Valencia Helen , Mayer Joachim , Möller Sören , Myung Seung‐Taek , Finsterbusch Martin , Guillon Olivier , Fattakhova‐Rohlfing Dina , Kaghazchi Payam 
Published: January 2024

AbstractIn this work, the effects of dopant size and oxidation state on the structure and electrochemical performance of LiNi0.8Co0.1Mn0.1O2 (NCM811) are investigated. It is shown that doping with boron (B) which has a small ionic radius and an oxidation state of 3+, leads to the formation of a boron oxide‐containing surface coating (probably Li3BO3), mainly on the outer surface of the secondary particles. Due to this effect, boron only slightly affects the size of the primary particle and the initial capacity, but significantly improves the capacity retention. On the other hand, the dopant ruthenium (Ru) with a larger ionic radius and a higher oxidation state of 5+ can be stabilized within the secondary particles and does not experience a segregation to the outer agglomerate surface. However, the Ru dopant preferentially occupies incoherent grain boundary sites, resulting in smaller primary particle size and initial capacity than for the B‐doped and pristine NCM811. This work demonstrates that a small percentage of dopant (2 mol%) cannot significantly affect bulk properties, but it can strongly influence the surface and/or grain boundary properties of microstructure and thus the overall performance of cathode materials.
Environmental and mechanical analysis of low‐carbon concrete with vitrified MSW incineration bottom ash as cement replacement
Authors: Sirico Alice , Bernardi Patrizia , Belletti Beatrice , Sciancalepore Corrado , Milanese Daniel , Paini Arianna , Vignali Giuseppe 
Published: January 2024

AbstractThe building sector is responsible for about 37% of the global carbon dioxide emissions, 6% of which result from concrete (and particularly cement) production. Using recycled and supplementary cementitious materials and adopting a whole building life cycle approach can be seen as multi‐beneficial strategies for materials' design. In this framework, this study aims to formulate a green concrete, by replacing 10, 15 and 20% of cement with a secondary raw material constituted of vitrified bottom ash derived from municipal solid waste incineration. The basic physical and mechanical properties were measured up to 365 days, so to evaluate the effects of the cement replacement both on short and long‐term behavior. Life Cycle Assessment was used as a tool to evaluate the environmental performance of the developed green concrete. An Eco‐Mechanical Analysis was also performed to match the environmental impacts with the mechanical behavior, allowing to assess that the concrete produced by replacing 20% of cement with vitrified municipal solid waste incineration bottom ash (if classified as hazardous waste) is the one that leads to optimize the overall sustainability. The approach proposed in this work, which can be easily generalized, contributes to the definition of a route for the implementation of innovative green construction building materials by using waste.
A metaheuristic‐based method for analysis of tensegrity structures
Authors: Bekdaş Gebrail , Ocak Ayla , Nigdeli Sinan Melih , Toklu Yusuf Cengiz 
Published: January 2024

SummaryTensegrity systems are construction system that offers solutions for lighter designs compared with a standard truss system consisting of tension and compression elements. Due to their structure, they are recommended in the design of space structures due to the use of lighter and easy‐to‐assemble structural elements such as cables, ropes, and similar to provide the desired durability. In this study, energy minimization was carried out to solve the structural element displacements. It is expected to reduce the total potential energy of the system with minimization. By minimizing the total potential energy of the tensegrity system models, the displacement of each building element is found for the equilibrium condition. Tensegrity models were analyzed by minimizing energy via the adaptive harmony search (AHS) algorithm. In this research, two distinct tensegrity structure specimens were employed. One comprised a cantilever beam, while the other adopted a cyclic model, forming eight equal octagons from eight nodes at both the base and the top. Additionally, an examination was conducted on a two‐layer iteration of the cyclic model. The method is robust for both space and planar tensegrity structures, allowing the determination of deformed shapes under various loads without design assumptions. The TPO/MA method demonstrates superiority in handling nonlinear and barely stable systems, as evidenced by examples illustrating its efficacy in maintaining structural form under increasing loads and challenging conditions.
Cerebrospinal fluid biomarker profiling of diverse pathophysiological domains in Alzheimer's disease
Authors: Trombetta Bianca A. , Wu Chao‐Yi , Kuo Evan , de Geus Matthijs B. , Dodge Hiroko H. , Carlyle Becky C. , Kivisäkk Pia , Arnold Steven E. 
Published: January 2024

AbstractINTRODUCTIONWhile Alzheimer's disease (AD) is defined by amyloid‐β plaques and tau tangles in the brain, it is evident that many other pathophysiological processes such as inflammation, neurovascular dysfunction, oxidative stress, and metabolic derangements also contribute to the disease process and that varying contributions of these pathways may reflect the heterogeneity of AD. Here, we used a previously validated panel of cerebrospinal fluid (CSF) biomarkers to explore the degree to which different pathophysiological domains are dysregulated in AD and how they relate to each other.METHODSTwenty‐five CSF biomarkers were analyzed in individuals with a clinical diagnosis of AD verified by positive CSF AD biomarkers (AD, n = 54) and cognitively unimpaired controls negative for CSF AD biomarkers (CU‐N, n = 26) using commercial single‐ and multi‐plex immunoassays.RESULTSWe noted that while AD was associated with increased levels of only three biomarkers (MMP‐10, FABP3, and 8OHdG) on a group level, half of all AD participants had increased levels of biomarkers belonging to at least two pathophysiological domains reflecting the diversity in AD. LASSO modeling showed that a panel of FABP3, 24OHC, MMP‐10, MMP‐2, and 8OHdG constituted the most relevant and minimally correlated set of variables differentiating AD from CU‐N. Interestingly, factor analysis showed that two markers of metabolism and oxidative stress (24OHC and 8OHdG) contributed independent information separate from MMP‐10 and FABP3 suggestive of two independent pathophysiological pathways in AD, one reflecting neurodegeneration and vascular pathology, and the other associated with metabolism and oxidative stress.DISCUSSIONBetter understanding of the heterogeneity among individuals with AD and the different contributions of pathophysiological processes besides amyloid‐β and tau will be crucial for optimizing personalized treatment strategies.Highlights
A panel of 25 highly validated biomarker assays were measured in CSF.
MMP10, FABP3, and 8OHdG were increased in AD in univariate analysis.
Many individuals with AD had increased levels of more than one biomarker.
Markers of metabolism and oxidative stress contributed to an AD multianalyte profile.
Assessing multiple biomarker domains is important to understand disease heterogeneity.