bluuebunny/crossref_metadata_2025_split huggingface dataset:
Algorithms in medical decision-making and in everyday life: what’s the difference?
Authors: Chartash David , Bruno Michael A. 
Published: February 2024

Abstract
Algorithms are a ubiquitous part of modern life. Despite being a component of medicine since early efforts to deploy computers in medicine, clinicians’ resistance to using decision support and use algorithms to address cognitive biases has been limited. This resistance is not just limited to the use of algorithmic clinical decision support, but also evidence and stochastic reasoning and the implications of the forcing function of the electronic medical record. Physician resistance to algorithmic support in clinical decision making is in stark contrast to their general acceptance of algorithmic support in other aspects of life.
Thermal proficiency of magnetized and radiative cross-ternary hybrid nanofluid flow induced by a vertical cylinder
Authors: Al-Kouz Wael , Owhaib Wahib , Ayub Assad , Souayeh Basma , Hader Montasir , Homod Raad Z. , Muhammad Taseer , Ishak Anuar , Khan Umair 
Published: February 2024

Abstract
The ternary hybrid nanofluid leads to a significant enhancement in thermal performance applications like heat transfer in automotive engines, solar thermal energy storage, aerospace, and electronic cooling. The present study investigates the thermal characteristics of a ternary hybrid magnetized and radiated cross nanofluid comprising Al2O3, TiO2, and Ag nanoparticles in water subjected to combined convection flow around a vertical cylinder. Furthermore, innovative effects of the magnetic field, absorber surface of the cylinder, non-linear thermal radiations, and effective thermophysical characteristics of ternary nanofluid are taken, and a new model for heat transport is successfully achieved. The governing equations in the form of partial differential equations (PDEs) are obtained through Navier–Stokes and heat equations by applying current assumptions. The system of PDEs is converted into a set of ordinary differential equations (ODEs) via a similarity variable. The built-in code bvp4c in Matlab software further exercises the dimensionless ODE equations numerically. Adding multiple nanoparticles and the magnetic field effect enhances the heat transfer rate in the ternary hybrid cross nanofluid. The Weissenberg number reduces the velocity, the radiation parameter increases heat transport, and the increased volume friction of nanoparticles enhances thermal conductivity and rapid heat transport.
Isopointal intermetallics: the cP24, dca phases as a representative set of examples, along with their vacancy-ordered variants β-Mn and SrSi2
Authors: Janka Oliver , Pöttgen Rainer 
Published: February 2024

Abstract
The crystal-chemical relationship of the cubic Laves phase MgCu2 (space group F

d

3
‾

$d\overline{3}$

m, cF24) with the ternary phases Cd2Cu3In, Na2Au3Al, Mg2Rh3P, Li2Pd3B, Ag2Pd3S, Cu3Pt2B, Mo3Al2C, Mo3Ni2N, and V3Ga2N (subgroup P4132, cP24, dca) is discussed based on a group-subgroup scheme. The course of the lattice parameters and the free positional parameters show substantially different distortions and thus clear differences in chemical bonding, classifying these phases as isopointal rather than isotypic (usually they are all assigned to the Mo3Al2C type). The group-subgroup scheme further shows that the β-Mn and SrSi2 structures are vacancy-ordered variants of the cP24, dca phases. The structures of Mn3IrSi and LaIrSi (space group types P213; translationengleiche subgroups) are their ternary ordered versions.
IT Master Plan Menggunakan Metode Ward And Papperd Pada DINKOMINFO Cilacap
Authors: Setiawan Ito , Biantoro Dwikris , Waluyo Retno , Eksandi Priski Fajar 
Published: February 2024

DINKOMINFO Cilacap memiliki bagian seperti urusan pemerintahan bidang sandi, bidang komunikasi dan informatika serta bidang statistik. Banyak sistem yang telah dibuat oleh DINKOMINFO Cilacap yang sudah dipakai di dinas-dinas terkait dan banyak juga permintaan pembuatan sistem dari dinas terkait untuk digunakan, namun permintaan sistem tersebut tidak melihat kemampuan sumber daya manusia yang akan menggunakan sistemnya serta melihat kebutuhan secara menyeluruh sehingga sistem yang diminta rata-rata berdiri sendiri tanpa ada integrasi sistem atau saling terkait antar sistem yang dibuat. Dari hal tersebut membuat kesulitan DINKOMINFO Cilacap dalam melakukan pengembangan sistem dikemudian hari. Permintaan untuk pengintergrasian sistem juga menjadi permasalahan tersendiri karena sebelumnya sistem tidak saling terkait dan membutuhkan waktu lama untuk proses tersebut. Merancang IT master plan pada DINKOMINFO Cilacap adalah tujuan dari penelitian ini. Metode yang digunakan pada penelitian ini mengacu metode ward and peppard yang mencangkup analisis PEST, SWOT, McFarland dan CSF. Hasil dari penelitian ini adalah usulan sistem yang sebaiknya diterapkan seperti implementasi smart city yang mencangkup Smart Living, Smart Environment, Smart Economy, Smart Mobilty, Smart Government dan Smart People. Usulan yang lain seperti Pengembangan e-pajak, digitalilasi pemerintahan desa dan kecamatan, SI Penanggulangan Kemiskinan, pengembangan smart kir, pengembangan aplikasi kepegewaian terintergrasi, e-tiket, e-commerce UMKM, pengembangan SIMBAJA, pengembangan e-edukasi, e-bangunan, e-wisata, e-lingkungan, e-transportasi, pengembangan database center, pengembangan digitalisasi pelayanan publik dan pengembangan portal website pemerintahan.
Varnos ir kranklio įvaizdis lietuvių ir slavų frazeologijoje bei etninėje kultūroje
Authors: Plachovičiūtė Diana 
Published: February 2024

The aim of the article is to explore whether the image of the crow and raven in Lithuanian phraseology and ethnic culture is similar to that of its Slavic neighbors or exhibits distinctive characteristics. The research material includes phraseological units in Lithuanian, Polish, Belarusian, and Russian with the components crow and raven. The analysis encompasses phraseologisms found in both vernacular and literary sources, applying the theory of conventional figurative language and the comparative method. Special attention is given to the portrayal of crows and ravens in folklore and folk beliefs. The findings reveal a predominantly negative perception of both birds in Lithuanian and Slavic phraseology and ethnic culture. The main features of the image of a crow and raven, which have developed in Lithuanian and Slavic phraseology and ethnic culture, are based on such characteristics as: black feathers, predatory behaviour, an unpleasant voice (the cry is mythologized, and it is associated with misfortunes and death). The image of the crow is often ironic and comical, while the image of the raven is much more negative. The crow is a cultural symbol of foolishness, while the raven is associated with wisdom. However, both Lithuanian and Slavic phraseology have their own peculiar images of the crow and the raven.
The Impact of Unemployment on Economic Development: Georgia's Example
Authors: Zhorzholiani Tinatin 
Published: February 2024

This study explores the intricate relationship between unemployment and economic development, with a specific focus on the case of Georgia. High unemployment rates often signal economic challenges within a nation, and their consequences can extend far beyond the labor market. By examining Georgia's experience, this research aims to shed light on the multifaceted impact of unemployment on various facets of economic growth.
Drawing from statistical data and regression analysis, this study investigates the causal links between unemployment levels and key economic indicators. It delves into how unemployment rates influence factors such as GDP growth, income inequality, social welfare programs, and overall societal well-being.
Furthermore, the study delves into the policy measures implemented in Georgia to combat unemployment and foster sustainable economic development. It scrutinizes the effectiveness of these policies, identifying successes and areas requiring improvement.
The insights gained from this analysis not only contribute to a deeper understanding of the dynamics between unemployment and economic development but also provide valuable lessons for policymakers and stakeholders in Georgia and other regions grappling with similar challenges. As nations worldwide seek to navigate the complex terrain of labor market dynamics and economic prosperity, the case of Georgia serves as an instructive example, highlighting the significance of addressing unemployment as a critical component of a nation's economic growth strategy.
Fibroblast growth factor 23 inhibition attenuates steroid-induced osteonecrosis of the femoral head through pyroptosis
Authors: Fang Lun , Zhang Gang , Wu Yadi , Li Hao , Li Zhongzhe , Yu Beilei , Wang Bin , Zhou Lu 
Published: February 2024

Abstract

Steroid-induced osteonecrosis of the femoral head (SONFH) is the predominant cause of non-traumatic osteonecrosis of the femoral head (ONFH). Impaired blood supply and reduced osteogenic activity of the femoral head are the key pathogenic mechanisms of SONFH. Fibroblast growth factor 23 (FGF23) levels are not only a biomarker for early vascular lesions caused by abnormal mineral metabolism, but can also act directly on the peripheral vascular system, leading to vascular pathology. The aim of this study was to observe the role of FGF23 on bone microarchitecture and vascular endothelium, and to investigate activation of pyroptosis in SONFH. Lipopolysaccharide (LPS) combined with methylprednisolone (MPS) was applied for SONFH mouse models, and adenovirus was used to increase or decrease the level of FGF23. Micro-CT and histopathological staining were used to observe the structure of the femoral head, and immunohistochemical staining was used to observe the vascular density. The cells were further cultured in vitro and placed in a hypoxic environment for 12h to simulate the microenvironment of vascular injury during SONFH. The effect of FGF23 on osteogenic differentiation was evaluated using alkaline phosphatase staining, alizarin red S staining and expression of bone formation-related proteins. Matrigel tube formation assay in vitro and immunofluorescence were used to detect the ability of FGF23 to affect endothelial cell angiogenesis. Steroids activated the pyroptosis signaling pathway, promoted the secretion of inflammatory factors in SONFH models, led to vascular endothelial dysfunction and damaged the femoral head structure. In addition, FGF23 inhibited the HUVECs angiogenesis and BMSCs osteogenic differentiation. FGF23 silencing attenuated steroid-induced osteonecrosis of the femoral head by inhibiting the pyroptosis signaling pathway, and promoting osteogenic differentiation of BMSCs and angiogenesis of HUVECs in vitro.
Perfusion changes in hepatocellular carcinoma and surrounding liver parenchyma based on perfusion CT imaging
Authors: Li Shanmei , Ji Guanghai , Gao Zhiling , Jia Jing , Chen Yong 
Published: February 2024

Abstract

Purpose
The aim of this study was to use computed tomography perfusion imaging (CTPI) to compare and analyze the differences in perfusion parameters between hepatocellular carcinoma (HCC) and surrounding tumor tissue before and after transarterial chemoembolization (TACE) to diagnose HCC and evaluate its curative effect.
Methods
Twenty-one HCC patients were examined by CTPI before and four weeks after TACE. Regions of interest (ROIs) were placed in the tumor (T1), peritumoral-1 cm (T2), peritumoral-2 cm (T3), and background liver parenchymal (T4) areas before TACE and in the residual tumor (T1a)/lipiodol-retaining (T1b) areas after TACE. The perfusion parameters included hepatic arterial perfusion (HAP), portal venous perfusion (PVP), total liver perfusion (TLP), the hepatic perfusion index (HPI), and the time to peak (TTP).
Results
A total of 32 lesions were detected, 11 lesions contained residual lesions, and 21 patients had good lipiodol deposition after TACE. The HAP and HPI signals demonstrated a decreasing trend (T1/T1a > T2 > T3 > T4), whereas the PVP and TLP signals showed an increasing trend (T1/T1a < T2 < T3 < T4) in the preoperative and postoperative residual groups, except for HAP and TLP in the T2 vs. T3, or HAP, HPI and TTP inT3 vs. T4 in postoperative residual, the remaining parameters are statistically significant. (p < 0.05). No blood perfusion was detected at T1b in the postoperative lipiodol-retaining group, and both the HAP and HPI signals reached their highest levels at T2, whereas the PVP, TLP, and TTP signals were highest at T4. The parameters of the T4 group were significantly different from those of the T2 and T3 groups (p < 0.05). Compared with those in the preoperative and residual groups, in the postoperative lipiodol group, the HAP and HPI were significantly lower, the PVP was significantly greater in T2 and T3, and TLP were significantly greater in T2 (p < 0.05).
Conclusion
CTPI can be used to evaluate the blood flow of hepatocellular carcinoma patients and surrounding areas before and after treatment. After TACE, the difference in perfusion in each area of the residual tumor group exhibited little change, while the difference in blood flow between the tumor and its surrounding area with dense lipiodol deposition greatly changed, which decreased the difference in perfusion between the tumor and the adjacent area. These findings provide reference data for the selection of treatment methods and postoperative evaluation.
LINC00885 promotes development of lung adenocarcinoma through AKT/mTOR/P70 signaling LINC00885 may regulate migration, proliferation, and invasion of lung adenocarcinoma through the mTOR pathway
Authors: Liang Zhu , Wan Wang , Su Wenmei , Dai Baizhen , Wang KangXian , Lin Guanzhou , Deng Biao , Wang Xuefeng , Zeng Guoxiong , Mao Qiyang , Zhang Rongjing , Wu Yanxia 
Published: February 2024

Abstract
Purpose
Previous studies have demonstrated the role of long non-coding RNAs (lncRNAs) in lung adenocarcinoma (LUAD).
Methods
Results
RNA sequencing analysis identified high LINC00885 expression levels in LUAD, especially in the middle and advanced stages. Our functional experiments showed that knocking down expression of LINC00885 using small interfering RNAs inhibited the growth, migration, invasion, and autophagy of LUAD cells, blocked cell cycle progression, and promoted apoptosis. LINC00885 knockdown also reduced protein expression levels of p21, MET, p-mTOR, and p-P70, suggesting that LINC00885 may regulate the growth and metastasis of LUAD through these signaling pathways. Further experiments revealed that an mTOR activator rescued inhibited cell growth, invasion, and migration following LINC00885 knockdown.
Conclusion
These findings demonstrate that LINC00885 may promote LUAD by regulating p21, MET, and mTOR/P70 signal transduction. They also suggest that LINC00885 may be a prognostic biomarker and therapeutic target in LUAD.
Intrinsic single-layer multiferroics in transition-metal-decorated chromium trihalides
Authors: Sun Jiatao , Liu Meng , He Shuyi , Ji Hongyan , Guo Jingda , Jiang Zhaotan , Gao Hong-Jun 
Published: February 2024

Abstract

Two-dimensional materials possessing intrinsic multiferroic properties have long been sought to harnessing the magnetoelectric coupling in nanoelectronic devices. Here, we report the achievement of robust type Ⅰ multiferroic order in single-layer chromium trihalides by decorating transition metal atoms. The out-of-plane ferroelectric polarization exhibits strong atomic selectivity, where 12 of 84 single-layer transition metal-based multiferroic materials possess out-of-plane ferroelectric or antiferroelectric polarization. Group theory reveals that this phenomenon is strongly dependent on p-d coupling and crystal field splitting. Cu decoration enhances the intrinsic ferromagnetism of trihalides and increases the ferromagnetic transition temperature. The magnetoelectric coupling in this system is studied by calculating the electric polarization of different ferroelectric structures (antiferroelectric and ferroelectric). Moreover, both ferroelectric and antiferroelectric phases are obtained, providing opportunities for electrical control of magnetism and energy storage and conversion applications. Furthermore, the transport properties of Cu(CrBr3)2 devices are calculated based on the nonequilibrium Green's function, and the results demonstrate outstanding spin filtering properties and a low-bias negative differential resistance effect for low power consumption. Our findings not only increase the understanding of two-dimensional multiferroic materials and demonstrate out-of-plane ferroelectric polarization but also reveal the mechanism of the emerging ferroelectricity and enhanced ferromagnetism, with promising applications in nanosized electronic and spintronic devices.
Effect of dexmedetomidine infusion on the analgesic duration of peripheral nerve blocks in dogs: a randomized clinical study
Authors: Franco Chiara , Batisti Elena , Boysen Søren , Patroncini Stefano , Alessandroni Emanuele , Briganti Angela 
Published: February 2024

Abstract

The aim of this study was to evaluate whether a continuous rate infusion (CRI) of dexmedetomidine could prolong the analgesic effect of peripheral nerve blocks. Twenty client-owned dogs were enrolled and randomly divided into 2 groups. The DEX group received dexmedetomidine infusion at 1 mcg kg-1 h-1, and the NaCl group received an equivalent volume infusion of saline. Sciatic, saphenous and obturator nerve blocks were performed using 0.1 mL kg-1 0.5% ropivacaine/block. Intraoperative fentanyl was administered if the heart rate and/or mean arterial pressure (MAP) increased >15% from the previous measurement, and vasopressors were administered if the MAP was ≤ 70 mmHg. Postoperative pain was assessed every hour using the Glasgow Composite Pain Scale (GCPS). Postoperative rescue analgesia consisted of methadone (0.2 mg kg-1 IV) and carprofen (2 mg kg-1 IV). A greater number of dogs in the NaCl group required fentanyl (5/10 p= 0.03) and vasopressors (8/10, p=0.02) than did those in the DEX group (0/10 and 2/10, respectively). The duration of postoperative analgesia was significantly longer (604 ± 130 minutes) in the DEX group than in the NaCl group (400 ± 81 minutes, p=0.0005).
Dexmedetomidine infusion at 1 mcg kg-1 h-1 reduces intraoperative analgesic and vasopressor requirements during orthopedic surgery and prolongs the postoperative analgesic effect of nerve blocks.
Experimental Insights to Stability of Graphene Oxide Polymer Hybrid: Effect of Salinity, Temperature and Divalent Ions Coupled with ANOVA Statistical Analysis
Authors: Iravani Mostafa , Simjoo Mohammad , Chahardowli Mohammad , Moghaddam Amir Rezvani 
Published: February 2024

Abstract

The synergistic potential of using graphene oxide (GO) and polymer as GO enhanced polymer (GOeP) hybrid for enhancing oil recovery (EOR) purposes has drawn attention. However, the hybridization method and stability of GOeP have not been comprehensively studied. To cover the gap, current study evaluates the stability of GOeP under different conditions, including temperature (60 and 80°C), salinity (sea water and its 0.1 dilution), and presence of Mg2+ ions (6430 and 643 ppm). Hence, GO was synthesized and characterized through XRD, Raman, FTIR, and DLS techniques. The performance of five preparation methods was assessed to determine their ability to produce stable hybrids. Zeta potential and sedimentation methods, coupled with ANOVA statistical technique, were used for measuring and interpreting stability for 21 days. Results revealed that the stability of GOeP in the presence of brine is influenced by hydrolyzation duration, the composition of the water used in polymer hydrolyzation, the form of additives (being powdery or in aqueous solution), and the dispersion quality, including whether the GO solution was prediluted. Results revealed that the positive impact of higher temperatures on long-term stability of the GOeP is approximately seven times lower than stability reduction caused by salinity. In conditions of elevated salinity, a higher Mg2+ concentration was observed to induce an 80% decrease in long-term stability, while the impact of temperature remained negligible. These findings highlight the importance of salinity and the role of Mg2+ in influencing the stability dynamics of the GOeP solution, with potential use for EOR purposes.
Serum EpCAM or PECAM levels and risk of ischemic stroke: a two-sample Mendelian randomization study
Authors: Gao Yikun , Li Yilin , Li Yina , Wang Jin , Cai Qiang , Gu Lijuan 
Published: February 2024

Abstract

Background and purpose
Elevated serum Epithelial cell adhesion molecule (EpCAM) or Platelet endothelial cell adhesion molecule (PECAM) are associated with ischemic stroke (IS), but the causality remains unclear. A two-sample Mendelian randomization (MR) study was performed to examine the causal effect of serum EpCAM or PECAM levels on the risk of IS subtypes.
Methods
Seven independent single-nucleotide polymorphisms (SNPs) related to serum EpCAM levels were identified as instrumental variables (IVs) from a genome-wide association study (GWAS) of 1,323 European subjects. 46 independent SNPs related to serum PECAM levels were identified as IVs from a GWAS of 21,758 European subjects. GWAS for IS subtypes included 410,484 (large artery stroke), 198,048 (small vessel stroke) and 413,304 (cardioembolic stroke) European individuals, respectively. All GWAS were obtained from the ieu open GWAS project. Mendelian Randomization (MR) analysis was conducted using the inverse variance-weighted (IVW) method, weighted median, MR–Egger, and maximum likelihood methods.
Results
No significant causal association was observed for EpCAM levels with any of three IS subtypes. Main IVW MR analysis indicated that serum PECAM levels were negatively related to the incidence of large artery stroke (LAS) and small vessel stroke (SVS) but not to cardioembolic stroke (CES). However, MR Egger method indicated a significant negative correlation between PECAM levels and CES risk. Sensitivity analyses showed the SNPs of PECAM exhibited pronounced horizontal pleiotropy in the CES GWAS. Therefore, serum PECAM levels are negatively correlated with CES risk significantly. In addition, no heterogeneity or outliers were found by MR-Egger and IVW in Cochran’s Q statistic. Finally, Leave-one-out analysis showed that no individual SNP substantially drove the causal association of serum PECAM levels on risk of IS subtypes.
Conclusions
High serum EpCAM levels show no clear causal relationship with the risk of LAS, SVS, and CES. But high serum PECAM levels were causally associated with decreased risks of LAS, SVS and CES.