bluuebunny/crossref_metadata_2025_split huggingface dataset:
Extracellular vesicle‐associated cholesterol supports the regenerative functions of macrophages in the brain
Authors: Vanherle Sam , Guns Jeroen , Loix Melanie , Mingneau Fleur , Dierckx Tess , Wouters Flore , Kuipers Koen , Vangansewinkel Tim , Wolfs Esther , Lins Paula Pincela , Bronckaers Annelies , Lambrichts Ivo , Dehairs Jonas , Swinnen Johannes V. , Verberk Sanne G. S. , Haidar Mansour , Hendriks Jerome J. A. , Bogie Jeroen F. J. 
Published: December 2023

AbstractMacrophages play major roles in the pathophysiology of various neurological disorders, being involved in seemingly opposing processes such as lesion progression and resolution. Yet, the molecular mechanisms that drive their harmful and benign effector functions remain poorly understood. Here, we demonstrate that extracellular vesicles (EVs) secreted by repair‐associated macrophages (RAMs) enhance remyelination ex vivo and in vivo by promoting the differentiation of oligodendrocyte precursor cells (OPCs). Guided by lipidomic analysis and applying cholesterol depletion and enrichment strategies, we find that EVs released by RAMs show markedly elevated cholesterol levels and that cholesterol abundance controls their reparative impact on OPC maturation and remyelination. Mechanistically, EV‐associated cholesterol was found to promote OPC differentiation predominantly through direct membrane fusion. Collectively, our findings highlight that EVs are essential for cholesterol trafficking in the brain and that changes in cholesterol abundance support the reparative impact of EVs released by macrophages in the brain, potentially having broad implications for therapeutic strategies aimed at promoting repair in neurodegenerative disorders.
Immune reconstitution inflammatory syndrome‐associated lymphoma: A retrospective Brazilian cohort
Authors: Vargas Juliano Cordova , Cecyn Karin Zattar , de Oliveira Marques Mariana , Pereira Juliana , Tobias Braga Walter M. , Hamerschlak Nelson , Tabacof Jacques , de Liz Caina D. , Abdo André , Ferreira Paulo Roberto Abrão , Colleoni Gisele W. Braga , Baiocchi Otavio C. G. 
Published: December 2023

AbstractAfter initiating combined antiretroviral therapy (cART), individuals with human immunodeficiency virus (HIV) may develop Hodgkin/non‐Hodgkin lymphoma due to immune reconstitution inflammatory syndrome (IRIS). This retrospective cohort study evaluated the incidence, clinical features and prognosis of IRIS‐associated lymphomas in Brazilian patients. Incidence in 2000–2019 was 9.8% (27/276 patients with HIV and lymphoma; viral load drop >1 log). Time between HIV diagnosis and cART initiation was <1 year in 70.3% of cases. Time between cART initiation and lymphoma diagnosis was <3 months in 11 cases and 3–6 months in 16 cases. Overall and progression‐free survival rates were similar between cases of non‐IRIS‐associated lymphoma and IRIS‐associated lymphoma.
Advanced procedures in Raman forensic, natural, and cultural heritage studies: Mobile set‐up, optics, and data treatment—State of the art and perspectives
Authors: Caggiani Maria Cristina , Colomban Philippe 
Published: December 2023

AbstractIn this introduction to the Journal of Raman Spectroscopy special issue “Advanced Raman procedures applied to natural/cultural heritage and forensic questions: Mobile set‐up, data treatment and associated techniques,” the aim is to assess the state of the art in the field and to highlight potential new perspectives. The novel approaches employed in the published papers are described and can be grouped as such: application of multivariate statistical analysis to Raman spectra, use of mobile instrumentations directly in situ for both cultural and forensic contexts, tackling with optics and spectral range issues, and coupling with mobile instrumentations based on different analytical techniques.
Prognostic significance of positive lymph node regression grade to neoadjuvant chemoradiation for esophageal squamous cell carcinoma
Authors: Yehan Zhou , Ying Liu , Peng Guo , Zongyao Huang , Chengmin Zhou , Hong Yang , Sheng Qin , Jie Zhu , Yi Wang , Xuefeng Leng , Wenwu He , Qifeng Wang , Yang Liu 
Published: December 2023

AbstractBackground and PurposeTo assess the relationship between metastatic lymph node (LN) responder status and recurrence‐free survival (RFS) in patients undergoing neoadjuvant chemoradiotherapy (NCRT).Materials and MethodsWe retrospectively reviewed 304 patients with local advanced esophageal squamous cell carcinoma received NCRT followed by esophagectomy. For 112 patients with positive node, according to the proportion of residual viable tumor cells area within the whole tumor beds of all metastatic LNs, we classified LN‐tumor regression grade (LN‐TRG) into four categories: grade 1, 0%; 2, <10%; 3, 10%−50%; 4, >50%. Patients with grade 1−2 LN‐TRG of were considered LN responders, and those with grades 3−4, as LN nonresponders. Univariate and multivariate analyses of RFS were estimated by a Cox regression model, Kaplan−Meier curve, and log‐rank test.ResultsThe median follow‐up time of a total of 112 patients was 29.6 months. Fifty‐two (46.4%) patients have experienced recurrence. In Cox univariate analysis, differentiation, AJCC stage LN responder status, nerve invasion, and lymphovascular invasion significantly correlated with RFS. Multivariate analysis for RFS revealed that LN responder status and AJCC stage (p < 0.05) were independent prognostic factor. The 3‐year RFS rates for patients with LN‐TRG of 1−4 grades were 72.7%, 76.5%, 37.4%, and 28.5%, respectively, and the median RFS times were not reach, 43.56, 28.09, and 22.77, respectively.ConclusionsLN responder status is an independent prognostic factor for RFS in esophageal cancer patients who received NCRT.
Psychological distress and pain related to gynecologic exams among female survivors of sexual and physical violence: A systematic review
Authors: Coleman Jessica N. , Arthur Sarah S. , Shelby Rebecca A. 
Published: December 2023

AbstractGender‐based violence is prevalent globally, yet the impacts of sexual and physical violence on women's experiences of routine gynecologic care are not well understood. The purpose of this systematic review of quantitative research is to describe (a) psychological distress and pain related to gynecologic exams among female survivors of sexual and physical violence and (b) differences in distress or pain between survivors and women without this history. Fourteen articles based on 12 discrete studies met the inclusion criteria. Studies were heterogeneous, with a moderate risk of bias; therefore, a descriptive summary approach was utilized rather than a meta‐analytic approach. Synthesized results indicated that survivors of violence experience mild‐to‐severe levels of distress and mild‐to‐moderate levels of pain related to gynecologic exams. The findings suggest that survivors of sexual or physical violence experience higher levels of distress than women without this history (i.e., moderate to severe), and this difference was further accentuated among women with more severe posttraumatic stress symptoms (PTSS). Differences in pain by violence history and PTSS severity were not consistently observed, possibly due to a lack of variability in ratings and small sample sizes. Additional research is needed that bolsters the measurement of exam‐related distress and pain, adjusts for confounding variables, and explores mechanisms by which sexual and physical violence impact care experiences. Further empirical work will be critical to developing interventions at the patient and provider levels to improve women's experiences of care.
Lichen planus pemphigoides erupting after COVID‐19 vaccination and infection, successfully treated with methotrexate
Authors: Andrén Josefin , Vassilaki Ismini , Curman Philip 
Published: December 2023

AbstractWe report a case of lichen planus pemphigoides (LPP) in a 36‐year‐old woman who presented bullous skin eruptions following both COVID‐19 infection and vaccination. The patient had a history of biopsy‐confirmed lichen planus since 2013 and had been previously investigated for suspected dermatitis herpetiformis since 2014, with inconclusive biopsy results. On two separate occasions, following her COVID‐19 vaccination and infection, she suffered the eruption of similar bullous lesions. A final diagnosis of LPP was established, believed to have been triggered by both the vaccination and the COVID‐19 infection. Treatment with prednisolone offered temporary relief, but sustained remission was achieved with methotrexate. This is, to our knowledge, the first documented case of LPP post‐COVID‐19 vaccination or infection.
Hole Mobility Enhancement in Benzo[1,2‐b:4,5‐b']Dithiophene‐Based Conjugated Polymer Transistors through Directional Alignment, Perovskite Functionalization and Solid‐State Electrolyte Gating
Authors: Nketia‐Yawson Vivian , Buer Albert Buertey , Ahn Hyungju , Nketia‐Yawson Benjamin , Jo Jea Woong 
Published: December 2023

AbstractTunability in electronic and optical properties has been intensively explored for developing conjugated polymers and their applications in organic and perovskite‐based electronics. Particularly, the charge carrier mobility of conjugated polymer semiconductors has been deemed to be a vital figure‐of‐merit for achieving high‐performance organic field‐effect transistors (OFETs). In this study, the systematic hole carrier mobility improvement of benzo[1,2‐b:4,5‐b']dithiophene‐based conjugated polymer in perovskite‐functionalized organic transistors is demonstrated. In conventional OFETs with a poly(methyl methacrylate) (PMMA) gate dielectric, improvements in hole mobility of 0.019 cm2 V−1 s−1 are measured using an off‐center spin‐coating technique, which exceeds those of on‐center counterparts (0.22 ± 0.07 × 10−2 cm2 V−1 s−1). Furthermore, the mobility drastically increases by adopting solid‐state electrolyte gating, corresponding to 2.99 ± 1.03 cm2 V−1 s−1 for the control, and the best hole mobility is 8.03 cm2 V−1 s−1 (average ≈ 6.94 ± 0.59 cm2 V−1 s−1) for perovskite‐functionalized OFETs with a high current on/off ratio of >106. The achieved device performance would be attributed to the enhanced film crystallinity and charge carrier density in the hybrid perovskite‐functionalized organic transistor channel, resulting from the high‐capacitance electrolyte dielectric.
Network evolutionary game analysis of green credit: A perspective of carbon emissions trading
Authors: Li Jingwei , Li Shouwei , Zhang Yonghong , Tang Xiaoyu 
Published: December 2023

AbstractAs an effective measure for the local government to promote reduction of corporate carbon emissions and sustainable development of social economy, the implementation of green finance policies in enterprises and financial institutions has encountered severe strikes from the low returns of low carbon production and low interest rates of green credit business. Under the premise of liberalizing carbon emissions trading, a triple‐level network evolutionary game consisting of a local government, banks, and enterprises is constructed to analyze response behavior and strategy selection mechanism to green credit. The impacts of management tools are investigated in terms of setting carbon market price, limiting the financing upper bound of misbehaving enterprises, limiting the emissions quota of enterprises for fraudulent green credit, and rewarding clean project development on the decisions of individuals in the network. Results show the following: First, increasing the trading price of carbon emissions has a catalytic effect on enhancing the activeness of banks and enterprises to follow green finance policies, but the autonomous regulation ability of which is limited. Second, reducing the funding ceiling for emitting emissions illegally ambiguates enterprises' preferences for production strategies and discourages them from undertaking low‐carbon projects. Third, excessive restrictions on the share of emissions may evoke regulatory inaction by the local government, consequently leading to instability in the evolution network. Fourth, granting reward for clean production is instrumental for the network to promote green finance policies, but exorbitant subsidies increase the fiscal burden of the local government with no significant effect on the node selection of environment‐friendly strategies.
Lysosomal Polygenic Burden Drives Cognitive Decline in Parkinson's Disease with Low Alzheimer Risk
Authors: Tunold Jon‐Anders , Tan Manuela M.X. , Toft Mathias , Ross Owen , van de Berg Wilma D.J. , Pihlstrøm Lasse 
Published: December 2023

AbstractBackgroundGenetics influence cognitive progression in Parkinson's disease, possibly through mechanisms related to Lewy and Alzheimer's disease pathology. Lysosomal polygenic burden has recently been linked to more severe Lewy pathology post mortem.ObjectivesTo assess the influence of lysosomal polygenic burden on cognitive progression in Parkinson's disease patients with low Alzheimer's disease risk.MethodsUsing Cox regression we assessed association between lysosomal polygenic scores and time to Montreal Cognitive Assessment score ≤ 21 in the Parkinson's Progression Markers Initiative cohort (n = 374), with replication in data from the Parkinson's Disease Biomarker Program (n = 777). Patients were stratified by Alzheimer's disease polygenic risk.ResultsThe lysosomal polygenic score was associated with faster progression of cognitive decline in patients with low Alzheimer's disease risk in both datasets (P = 0.0032 and P = 0.0054, respectively).ConclusionOur study supports complex interplay between genetics and neuropathology in Parkinson's disease‐related cognitive impairment, emphasizing the role of lysosomal polygenic burden. © 2023 The Authors. Movement Disorders published by Wiley Periodicals LLC on behalf of International Parkinson and Movement Disorder Society.
Second‐order necessary optimality conditions for discrete‐time stochastic systems
Authors: Song Teng , Yao Yong 
Published: December 2023

SummaryThis paper deals with the second‐order necessary optimality conditions for discrete‐time stochastic optimal control problems under weakened convexity assumptions. Using a special variation of the control, and by virtue of a new discrete‐time backward stochastic equation, we establish a more general and constructive first‐order necessary optimality condition in the form of a global stochastic maximum principle. Moreover, by introducing a new discrete‐time backward stochastic matrix equation, the second‐order multipoint necessary optimality conditions of singular controls are derived, which covers and improves the classical second‐order necessary optimality conditions of discrete‐time stochastic systems.
Hypoglossal Nerve Stimulation Effects on Obstructive Sleep Apnea Over Time: A Systematic Review and Meta‐analysis
Authors: Kim Do Hyun , Kim Sung Won , Han Jae Sang , Kim Geun‐Jeon , Basurrah Mohammed Abdullah , Hwang Se Hwan 
Published: December 2023

AbstractObjectivesThis study aimed to determine the efficacy of hypoglossal nerve stimulation (HGS) in the treatment of obstructive sleep apnea.Data SourcesPubMed, Cochrane database, Embase, Web of Science, SCOPUS, and Google Scholar.Review MethodsFive databases were reviewed to identify relevant studies that measured polysomnography parameters such as the apnea‐hypopnea index (AHI) and oxygen desaturation index, as well as quality of life and functional outcomes of sleep questionnaire scores, before and after HGS.ResultsIn total, 44 studies involving 8670 patients met the inclusion criteria. At 12 months after treatment, approximately 47%, 72%, and 82% of patients achieved AHI values of <5, < 10, and <15, respectively. The reported clinical success rates according to Sher criteria were 80% within 12 months and 73% between 12 and 36 months. While the favorable effects exhibited a gradual reduction up to 12 months postimplantation, they generally maintained a consistent level between the 12th and 36th months, as assessed by AHI < 5, <15, and success rate according to Sher criteria.ConclusionHGS can enhance quality of life scores and polysomnography outcomes in obstructive sleep apnea patients. Although the positive effects gradually decreased until 12 months after implantation, they generally remained consistent between 12 and 36 months.
The Effect of Postoperative Naloxone in Certain Otolaryngologic Surgeries
Authors: Perlov Natalie M. , Shah Sohan S. , Bluj Joann , Urdang Zachary D. , Chiffer Rebecca C. 
Published: December 2023

AbstractObjectiveTo evaluate the association of postoperative naloxone with the development of new substance use disorder (SUD), overdose, and death within 6 months of otolaryngologic surgery.Study DesignRetrospective cohort database study on TriNetX.MethodsAdult patients who underwent tonsil surgery (noncancerous), thyroid/parathyroid, septorhinoplasty, otology/neurotology, sinus/anterior skull base, and head and neck cancer surgeries between January 2003 and April 2023. Patients were excluded if they had an instance of SUD or overdose recorded in their charts prior to surgery, or had undergone another surgery within that 6‐month time frame. We hypothesized that patients prescribed naloxone postoperatively would have decreased odds for experiencing new SUD, overdose, and/or death within 6 months of surgery compared to patients who did not receive naloxone. P < .01 was considered statistically significant.ResultsThere were 2,305,655 patients in this study. The average age was 36.7 ± 19.5 years old, with 46% female patients. Before matching, cohorts showed equivocal odds for developing new SUD, increased odds for overdose, and mixed odds for dying. After matching for demographic variables and comorbidities such as other substance use, opioid use for other pathologies, and psychiatric conditions, these effects diminished (P > .01).ConclusionOur results suggest that postoperative naloxone may not significantly affect development of new SUD and incident overdose and death in certain otolaryngologic surgeries after controlling for prior SUD and psychiatric conditions. Clinicians should be aware of these comorbidities when considering their postoperative pain management protocol, which may or may not include naloxone.
Nanomechanical analysis of friction welded similar PEEK/aluminum nanocomposites: Effect of metal particle reinforcement
Authors: Senkathir S. , Pramanik Sumit , Mukherjee Manidipto 
Published: December 2023

AbstractAluminum (Al), poly(etheretherketone) (PEEK) thermoplastics, and their individual composites have widely been used in many industries, including aerospace and biomedical fields. However, the joining process of those composites has not been explored much to date. In this context, the friction welding process (FWP) could be used as an alternative since it has the ability to join high‐strength components with minimal distortion. Therefore, the present study aimed to develop PEEK/Al nanocomposites with varying Al concentrations of 10, 20, 30, and 40 vol% using powder metallurgical technique and further joined the similar composition composites by FWP. Then, the effect of reinforced particle concentrations on the physical, morphological, structural, thermal, and micromechanical behaviors of the joined nanocomposites has been characterized by microscopy, X‐ray diffraction, differential scanning calorimetry, and nanoindentation tests. The concentrations of the reinforcement were found to have a significant effect on the crystallinity, melting temperature, glass transition temperature, and thereby micromechanical properties. The results were analyzed and correlated precisely for all the welded nanocomposites systematically. The interdiffusion mechanism was found to be involved in improving the mechanical properties of the present nanocomposites. The highest elastic modulus (13.91 GPa) or nanohardness (0.31 GPa) was obtained for the rotatory part of the PEEK/Al40 nanocomposites at 80 mN load. But, the applied load of 40 mN was the best loading condition due to the uniform change in modulus and nanohardness of all the nanocomposites. Therefore, the present alternative joining method of the PEEK/Al nanocomposites might be used for aerospace components.Highlights
Development of PEEK/aluminum with 10, 20, 30 and 40 vol% Al nanocomposites.
Friction welding of similar composite material, PEEK/Al‐PEEK/Al nanocomposites.
Microstructural, thermal, and nanomechanical analyses.
Effect of metal particle reinforcement on the friction welded nanocomposites.
FW PEEK/Al40 nanocomposite is found to be the best.
Open‐source photovoltaic model pipeline validation against well‐characterized system data
Authors: Deville Lelia , Theristis Marios , King Bruce H. , Chambers Terrence L. , Stein Joshua S. 
Published: December 2023

AbstractAll freely available plane‐of‐array (POA) transposition models and photovoltaic (PV) temperature and performance models in pvlib‐python and pvpltools‐python were examined against multiyear field data from Albuquerque, New Mexico. The data include different PV systems composed of crystalline silicon modules that vary in cell type, module construction, and materials. These systems have been characterized via IEC 61853‐1 and 61853‐2 testing, and the input data for each model were sourced from these system‐specific test results, rather than considering any generic input data (e.g., manufacturer's specification [spec] sheets or generic Panneau Solaire [PAN] files). Six POA transposition models, 7 temperature models, and 12 performance models are included in this comparative analysis. These freely available models were proven effective across many different types of technologies. The POA transposition models exhibited average normalized mean bias errors (NMBEs) within ±3%. Most PV temperature models underestimated temperature exhibiting mean and median residuals ranging from −6.5°C to 2.7°C; all temperature models saw a reduction in root mean square error when using transient assumptions over steady state. The performance models demonstrated similar behavior with a first and third interquartile NMBEs within ±4.2% and an overall average NMBE within ±2.3%. Although differences among models were observed at different times of the day/year, this study shows that the availability of system‐specific input data is more important than model selection. For example, using spec sheet or generic PAN file data with a complex PV performance model does not guarantee a better accuracy than a simpler PV performance model that uses system‐specific data.
Hydrolysis of phosphate diester catalyzed by new mononuclear copper(II) complexes containing selenium ligands
Authors: Duarte Laura S. , Durigon Daniele C. , Braga Antonio L. , Peralta Rosely A. 
Published: December 2023

AbstractThree new copper(II) mononuclear complexes containing different organoselenium groups (1–3) were synthesized and characterized by the following techniques: elemental analysis, IR and UV‐Vis spectroscopies, electrochemical and conductimetric analysis, and mass spectrometry. Three new complexes, with substituents made in the para position of the aromatic portion of the N,N‐bis(2‐(phenylselanyl)ethyl)amine ligand: p‐OCH3 (1), p‐CH3 (2), and p‐Cl (3), were synthetized to compare with the already published complex (4), with no substituents. The ligand coordinates to the copper(II) center in a tridentate way with Se, N, Se as donor atoms. The hydrolytic activity in phosphate diester cleavage of the complexes was investigated using 2,4‐BDNPP as substrate. The modifications in the ligand are reflected in the difference between the catalytic and activation parameters, where the kcat values follow the order: 4 > 2 > 3 > 1.