bluuebunny/crossref_metadata_2025_split huggingface dataset:
Co/Mon Invigorated Bilateral Kinetics Modulation for Advanced Lithium–Sulfur Batteries
Authors: Kong Yueyue , Wang Lu , Mamoor Muhammad , Wang Bin , Qu Guangmeng , Jing Zhongxin , Pang Yingping , Wang Fengbo , Yang Xiaofan , Wang Dedong , Xu Liqiang 
Published: December 2023

AbstractSluggish sulfur redox kinetics and Li‐dendrite growth are the main bottlenecks for lithium–sulfur (Li–S) batteries. Separator modification serves as a dual‐purpose approach to address both of these challenges. In this study, the Co/MoN composite is rationally designed and applied as the modifier to modulate the electrochemical kinetics on both sides of the sulfur cathode and lithium anode. Benefiting from its adsorption‐catalysis function, the decorated separators (Co/MoN@PP) not only effectively inhibit polysulfides (LiPSs) shuttle and accelerate their electrochemical conversion but also boost Li+ flux, realizing uniform Li plating/stripping. The accelerated LiPSs conversion kinetics and excellent sulfur redox reversibility triggered by Co/MoN modified separators are evidenced by performance, in‐situ Raman detection and theoretical calculations. The batteries with Co/MoN@PP achieve a high initial discharge capacity of 1570 mAh g−1 at 0.2 C with a low decay rate of 0.39%, uniform Li+ transportation at 1 mA cm−2 over 800 h. Moreover, the areal capacity of 4.62 mAh cm−2 is achieved under high mass loadings of 4.92 mg cm−2. This study provides a feasible strategy for the rational utilization of the synergistic effect of composite with multifunctional microdomains to solve the problems of Li anode and S cathode toward long‐cycling Li–S batteries.
2D Halide Perovskite Phase Formation Dynamics and Their Regulation by Co‐Additives for Efficient Solar Cells
Authors: Liu Min , Zheng Daming , Zhu Tao , Vegso Karol , Siffalovic Peter , Pauporté Thierry 
Published: December 2023

AbstractThe incorporation of large organic ammonium ions renders the crystallization dynamics and layer formation process of halide perovskites complex, difficult to control, and leads to problems of suppressed charge transport with the formation of tiny‐sized grains. In this paper, the use of methylammonium chloride (MACl) and an excess of PbI2 is introduced as a co‐additives in the precursor solution for the control of phenylmethylammonium or benzylammonium (PMA+ spacer) and formamidinium (FA+)‐based quasi‐2D PMA2FAn−1PbnI3n+1 (n = 5) perovskite layers formation. By this method, the morphology of the layer, the inner phase distribution, and the charge transport properties are improved. By employing glow discharge‐optical emission spectroscopy (GD‐OES) and other techniques, it is revealed that the quasi‐2D perovskites prepared in the presence of co‐additives exhibit uniform removal dynamics of the solvent across the film. Furthermore, the grain growth mode, upon thermal annealing, is lateral. It results in large, monolithic grains with low‐trap state density and excellent substrate coverage. Particularly, co‐additives improve the cations dispersion upon the crystallization process, thus suppressing the low‐n phase formed through the aggregation of spacer cations and accelerating the formation of the high‐n phase.
Long‐term use of everolimus for refractory arrhythmia in a child with tuberous sclerosis complex
Authors: Hofmann Christoph , Syrbe Steffen , Hebe Joachim , Kreft Jannis , Stark Sebastian , Milde Till , Völkers Mirko , Hoffmann Georg Friedrich , Gorenflo Matthias , Kovacevic Alexander 
Published: December 2023

AbstractTuberous sclerosis complex is associated with the occurrence of cardiac rhabdomyomas that may result in life‐threatening arrhythmia unresponsive to standard antiarrhythmic therapy. We report the case of an infant with multiple cardiac rhabdomyomas who developed severe refractory supraventricular tachycardia (SVT) that was successfully treated with everolimus. Pharmacological mTOR inhibition rapidly improved arrhythmia within few weeks after treatment initiation and correlated with a reduction in tumor size. Intermediate attempts to discontinue everolimus resulted in rhabdomyoma size rebound and recurrence of arrhythmic episodes, which resolved on resumption of therapy. While everolimus treatment led to successful control of arrhythmia in the first years of life, episodes of SVT reoccurred at the age of 6 years. Electrophysiologic testing confirmed an accessory pathway that was successfully ablated, resulting in freedom of arrhythmic events. In summary we present an in‐depth evaluation of the long‐term use of everolimus in a child with TSC‐associated SVT, including the correlation between drug use and arrhythmia outcome. This case report provides important information on the safety and efficacy of an mTOR inhibitor for the treatment of a potentially life‐threatening cardiac disease manifestation in TSC for which the optimal treatment strategy is still not well established.
Production of high quality biodiesel from sunflower soapstock acid oil as novel feedstock: Catalyzed by immobilized pancreatic lipase
Authors: Paluzar Hatice 
Published: December 2023

AbstractEdible refined oils, which are utilized as raw materials in biodiesel production, have been replaced by by‐products (acid oil, fatty acid, deodorized distillate, and soapstock distillates) obtained from the vegetable oil refining industry, in recent years. This study aims to investigate the production of high quality biodiesel fuel in accordance with the standards (TS EN and ASTM) from sunflower soapstock acid oil. This feedstock was donated by an oil factory in the Thrace region, Turkey. Esterification reaction was performed by immobilized enzyme. For this, immobilization was carried out by covalent binding of pancreatic lipase in glutaraldehyde activated chitosan and optimum immobilization conditions were determined. The activity of the immobilized lipase and the retained activity were found to be 65.69 U/μg and 61.8%, respectively (pH: 7.5, 37°C). The Km (Michealis constant) and Vmax (maximum velocity of an enzymatically catalyzed reaction) values of the immobilized enzyme were found to be 5.1 mmol/L and 48.6 U/min/mg protein, respectively. The immobilized enzyme was employed as a biocatalyst for esterification of sunflower soapstock acid oil. Notably, an impressive yield of 75.6% was attained under the conditions of a 1:5 molar ratio of soapstock acid oil to methanol, with 10 wt% immobilized lipase as the catalyst, and a reaction temperature of 45°C for 36 h. The resulting biodiesel exhibits fuel characteristics that meet the standards outlined in TS EN 14214:2012 + A2 and ASTM D6751‐02.
Hintergründe und Grundlagen zur Anwendung von Brandschutzbekleidungen im Holzbau
Authors: Kurzer Christoph , Werther Norman , Winter Stefan , Zehfuß Jochen 
Published: December 2023

AbstractDieser Beitrag fasst den aktuellen Wissensstand und Hintergründe in der nationalen und internationalen Anwendung von Brandschutzbekleidungen im Holzbau zusammen. Hierbei wird auf die unterschiedlichen Arten von Brandschutzbekleidungen, deren normative und bauordnungsrechtliche Definitionen und deren Leistungsanforderungen eingegangen und zugehörige Unterschiede vergleichend dargestellt. Aus der Diskussion der Hintergründe wird so eine erweiterte Sichtweise auf die nachzuweisenden Kriterien bei Brandschutzbekleidungen für Holzbauteile entwickelt, die eine optimierte Betrachtung und ressourcenschonendere Anwendung bei Wahrung des brandschutztechnischen Sicherheitsniveaus ermöglicht.
Extracellular vesicles (EVs): A promising therapeutic tool in the heart tissue regeneration
Authors: Diomede Francesca , Guarnieri Simone , Lanuti Paola , Konstantinidou Fani , Gatta Valentina , Rajan Thangavelu Soundara , Pierdomenico Sante D. , Trubiani Oriana , Marconi Guya Diletta , Pizzicannella Jacopo 
Published: December 2023

AbstractMesenchymal stem cells (MSCs) treatment has been widely explored as a therapy for myocardial infarction, peripheral ischemic vascular diseases, dilated cardiomyopathy, and pulmonary hypertension. Latest in vitro studies suggest that MSCs can differentiate into contractile cardiomyocytes. One of the best‐characterized MSCs products are MSCs‐derived extracellular vesicles (EVs). EVs are crucial paracrine effectors of MSCs. Based on previous works, paracrine effects of MSCs play a primary role in the regenerative ability. Hence, in the current paper, we focused our attention on an alternative approach, exploiting products derived from human dental pulp stem cells (hDPSCs) rather than MSCs themselves, which may denote a cost‐effective and safer approach. The focus has been on EVs and the bioactive molecules they contain to evaluate their ability to influence the differentiation process toward cardiomyogenic lineage. The expression of GATA4, ACTC1, CX43, and Nkx2.5 was evaluated using Immunofluorescence, real time‐PCR, and Western blotting analyses. Furthermore, the expression profiling analysis of the microRNA hsa‐miR‐200c‐3p, targeting the GATA4 gene, was studied. The hsa‐miR‐200c‐3p was found significantly down‐regulated in both c‐hDPSCs + EVs‐hDPSCs and c‐hDPSCs + EVs‐HL‐1 compared to untreated c‐hDPSCs underlying a possible epigenetic mechanism behind the prevalent up‐regulation of its targeted GATA4 gene. The aim of the present work was to develop an in vitro model of hDPSCs able to differentiate into cardiomyocytes in order to investigate the role of EVs derived from hDPSCs and derived from HL‐1 cardiomyocyte cell line in modulating the differentiation process toward cardiomyogenic lineage.
A dynamic time‐to‐event model for prediction of acute graft‐versus‐host disease in patients after allogeneic hematopoietic stem cell transplantation
Authors: Och Katharina , Turki Amin T. , Götz Katharina M. , Selzer Dominik , Brossette Christian , Theobald Stefan , Braun Yvonne , Graf Norbert , Rauch Jochen , Rohm Kerstin , Weiler Gabriele , Kiefer Stephan , Schwarz Ulf , Eisenberg Lisa , Pfeifer Nico , Ihle Matthias , Grandjean Andrea , Fix Sonja , Riede Claudia , Rissland Jürgen , Smola Sigrun , Beelen Dietrich W. , Kaddu‐Mulindwa Dominic , Bittenbring Jörg , Lehr Thorsten 
Published: December 2023

AbstractBackgroundAcute graft‐versus‐host disease (aGvHD) is a major cause of death for patients following allogeneic hematopoietic stem cell transplantation (HSCT). Effective management of moderate to severe aGvHD remains challenging despite recent advances in HSCT, emphasizing the importance of prophylaxis and risk factor identification.MethodsIn this study, we analyzed data from 1479 adults who underwent HSCT between 2005 and 2017 to investigate the effects of aGvHD prophylaxis and time‐dependent risk factors on the development of grades II–IV aGvHD within 100 days post‐HSCT.ResultsUsing a dynamic longitudinal time‐to‐event model, we observed a non‐monotonic baseline hazard overtime with a low hazard during the first few days and a maximum hazard at day 17, described by Bateman function with a mean transit time of approximately 11 days. Multivariable analysis revealed significant time‐dependent effects of white blood cell counts and cyclosporine A exposure as well as static effects of female donors for male recipients, patients with matched related donors, conditioning regimen consisting of fludarabine plus total body irradiation, and patient age in recipients of grafts from related donors on the risk to develop grades II–IV aGvHD. Additionally, we found that higher cumulative hazard on day 7 after allo‐HSCT are associated with an increased incidence of grades II–IV aGvHD within 100 days indicating that an individual assessment of the cumulative hazard on day 7 could potentially serve as valuable predictor for later grades II–IV aGvHD development. Using the final model, stochastic simulations were performed to explore covariate effects on the cumulative incidence over time and to estimate risk ratios.ConclusionOverall, the presented model showed good descriptive and predictive performance and provides valuable insights into the interplay of multiple static and time‐dependent risk factors for the prediction of aGvHD.
Changes in serum DAMPs and cytokines/chemokines during near‐infrared photoimmunotherapy for patients with head and neck cancer
Authors: Ishihara Hiromasa , Nishikawa Daisuke , Muraoka Daisuke , Masago Katsuhiro , Beppu Shintaro , Terada Hoshino , Matsushita Hirokazu , Hanai Nobuhiro 
Published: December 2023

AbstractBackgroundNear‐infrared photoimmunotherapy (NIR‐PIT) for head and neck cancer is a recently developed therapy. However, there is limited data on patients receiving NIR‐PIT in real clinical settings.MethodsSeven NIR‐PIT sessions were administered to five patients with head and neck squamous cell carcinoma (HNSCC). Serum damage‐associated molecular patterns (DAMPs) (HMGB1 and Hsp70 levels), and cytokine and chemokine production, were compared before and after NIR‐PIT.ResultsThe serum concentration of HMGB1 increased after NIR‐PIT (p = 0.031, Wilcoxon test) in all patients except one who did not achieve a clinical response. Chemokines MIP‐1α (CCL3) and MIP‐1β (CCL4) increased significantly 1–3 days after treatment (CCL3, p = 0.0036; CCL4, p = 0.0016, Wilcoxon test). A low pre‐treatment neutrophil‐to‐lymphocyte ratio (NLR) was associated with a better response to therapy and survival.ConclusionsThe release of DAMPs, and cytokine/chemokine production, were detected in the patients' peripheral blood. The baseline NLR may predict patient outcomes in response to NIR‐PIT.
Serum CXCL10 levels at the start of the second course of atezolizumab plus bevacizumab therapy predict therapeutic efficacy in patients with advanced BCLC stage C hepatocellular carcinoma: A multicenter analysis
Authors: Suzuki Takanori , Matsuura Kentaro , Suzuki Yuta , Okumura Fumihiro , Nagura Yoshihito , Sobue Satoshi , Matoya Sho , Miyaki Tomokatsu , Kimura Yoshihide , Kusakabe Atsunori , Narahara Satoshi , Tokunaga Takayuki , Nagaoka Katsuya , Kuroyanagi Keita , Kawamura Hayato , Kuno Kayoko , Fujiwara Kei , Nojiri Shunsuke , Kataoka Hiromi , Tanaka Yasuhito 
Published: December 2023

AbstractBackground & AimsRelationships of serum C‐C motif chemokine ligand 5 (CCL5) and C‐X‐C motif chemokine ligand 10 (CXCL10) levels with hot immune features have been reported in patients with hepatocellular carcinoma (HCC). Therefore, we examined the utility of their levels for predicting the efficacy of atezolizumab plus bevacizumab (Atez/Bev) in patients with HCC.DesignIn total, 98 patients with HCC treated with Atez/Bev were enrolled, and their initial responses were evaluated at least once via dynamic computed tomography or magnetic resonance imaging. Serum CCL5 and CXCL10 levels were assessed by enzyme‐linked immunosorbent assay before treatment and at the start of the second course of Atez/Bev therapy, and their relationships with treatment efficacy were determined.ResultsNo analyzed factor was associated with the initial therapeutic response. Among the 56 patients with Barcelona Clinic Liver Cancer (BCLC) stage C, serum CXCL10 levels at the beginning of course two (CXCL10‐2c) tended to be higher in responders than in non‐responders in the initial evaluation, and its optimal cutoff level of 690 pg/mL could be used to stratify patients regarding overall survival (OS; high vs. low: not reached vs. 17.6 months, p = 0.034) and progression‐free survival (high vs. low: 13.6 vs. 5.1 months, p = 0.014). In multivariate analysis, high CXCL10 levels and neutrophil‐to‐lymphocyte ratios at the start of course two and Child–Pugh stage A at baseline were independent predictive factors of improved OS.ConclusionsSerum CXCL10‐2c levels were predictive of Atez/Bev efficacy in patients with BCLC stage C HCC.
Recent Progress and Prospects of MXene/Cellulose‐Based Composite Electrodes: A Sustainable Pathway towards Supercapacitor Application
Authors: Krishna Paul Tamal , Parvez Md. Shohan , Mashfik Ahmed Chowdhury 
Published: December 2023

AbstractMXenes, a group of two‐dimensional (2D) metal carbides and nitrides, have emerged as promising electrode materials for supercapacitors. This is primarily attributed to their inherent metal‐like electrical conductivity, layered structure, surface redox reactivity, and superior pseudocapacitance through surface functional groups. Owing to its promising features, this material suffers from low mechanical strength, restacking, and unprecedented oxidation. As a result, balancing the electrochemical performance becomes challenging, eventually impeding its potential applications in lightweight, flexible supercapacitor applications. Recent strategies are centered on lighter and more stable filler materials to tackle these issues. Among these, cellulose is considered one of the most effective renewable materials because of its biocompatibility, thermal stability, high surface area, and mechanical reinforcement. Moreover, nanocellulose is capable of hosting other functional materials on its reactive surfaces, ensuring better ion accessibility, and can be used as an electrolyte separator membrane. This review paper aims to provide a comprehensive overview of recent advances in the fabrication strategy, deterministic parameters for capacitive energy‐storage devices, electrochemical behavior, and the performance of MXene/cellulose‐based electrodes in its three‐dimensional aspect (1D, 2D and 3D) for supercapacitor application. Lastly, this review will outline the challenges and prospects of MXene/cellulose‐based composite electrodes in real‐life supercapacitor applications.
Electroanalytical Immunotool to Determine Matricellular Protein Periostin, a Stromal Biomarker of Prognosis in Colorectal Cancer
Authors: Blázquez‐García Marina , Quinchia Jennifer , Ruiz‐Valdepeñas Montiel Víctor , Torrente‐Rodríguez Rebeca M. , Serafín Verónica , Garranzo‐Asensio María , García‐Romero Ana , Orozco Jahir , Barderas Rodrigo , Pingarrón José M. , Campuzano Susana 
Published: December 2023

AbstractTumor‐associated stroma biomarkers are emerging as key signaling molecules of metastasis in colorectal cancer (CRC). In this sense, periostin (POSTN), a protein of the extracellular matrix from the stromal compartment, is envisioned as a potential stromal prognostic biomarker, which facilitates the application of pertinent treatments. In this work, we report an easy‐to‐handle amperometric sandwich‐based immunosensing strategy for the determination of POSTN involving commercial magnetic microparticles (MBs), disposable carbon electrodes, and the horseradish peroxidase (HRP)/H2O2/hydroquinone (HQ) electrochemical system. The method allowed a dynamic linear range between 0.47 and 25 ng mL−1 and a limit of detection, LOD, of 0.14 ng mL−1 compatible with clinical demands. The method was applied to the analysis of POSTN in a variety of cancer‐related real bio‐scenarios including cell extracts and secretomes from CRC cells, and plasma from CRC patients at different stages. The potentials of this firstly developed MBs‐assisted immunoplatform are justified by distinguishing between metastatic abilities of cultured CRC cells through the analysis of their extracts and secretomes, and by differentiating between healthy controls and CRC patients in just 60 min. Therefore, the developed immunoplatform can be envisaged as a novel and profitable tool for exploring the most uncharacterized but prospective tumor areas.
Compositional engineering of HKUST‐1/sulfidized NiMn‐LDH on functionalized MWCNTs as remarkable bifunctional electrocatalysts for water splitting
Authors: Chen Mengshan , Abazari Reza , Sanati Soheila , Chen Jing , Sun Mingyuzhi , Bai Cunhong , Kirillov Alexander M. , Zhou Yingtang , Hu Guangzhi 
Published: December 2023

AbstractWater‐splitting reactions such as the hydrogen evolution reaction (HER) and the oxygen evolution reaction (OER) typically require expensive noble metal‐based electrocatalysts. This has motivated researchers to develop novel, cost‐effective electrocatalytic systems. In this study, a new multicomponent nanocomposite was assembled by combining functionalized multiwalled carbon nanotubes, a Cu‐based metal–organic framework (MOF) (HKUST‐1 or HK), and a sulfidized NiMn‐layered double hydroxide (NiMn‐S). The resulting nanocomposite, abbreviated as MW/HK/NiMn‐S, features a unique architecture, high porosity, numerous electroactive Cu/Ni/Mn sites, fast charge transfer, excellent structural stability, and conductivity. At a current density of 10 mA cm−2, this dual‐function electrocatalyst shows remarkable performance, with ultralow overpotential values of 163 mV (OER) or 73 mV (HER), as well as low Tafel slopes (57 and 75 mV dec−1, respectively). Additionally, its high turnover frequency values (4.43 s−1 for OER; 3.96 s−1 for HER) are significantly superior to those of standard noble metal‐based Pt/C and IrO2 systems. The synergistic effect of the nanocomposite's different components is responsible for its enhanced electrocatalytic performance. A density functional theory study revealed that the multi‐interface and multicomponent heterostructure contribute to increased electrical conductivity and decreased energy barrier, resulting in superior electrocatalytic HER/OER activity. This study presents a novel vision for designing advanced electrocatalysts with superior performance in water splitting. Various composites have been utilized in water‐splitting applications. This study investigates the use of the MW/HK/NiMn‐S electrocatalyst for water splitting for the first time to indicate the synergistic effect between carbon‐based materials along with layered double hydroxide compounds and porous compounds of MOF. The unique features of each component in this composite can be an interesting topic in the field of water splitting.
Colloidal ruthenium catalysts for selective quinaldine hydrogenation: Ligand and solvent effects
Authors: Colliere Vincent , Verelst Marc , Lecante Pierre , Axet M. Rosa 
Published: December 2023

AbstractColloidal Ru nanoparticles (NP) display interesting catalytic properties for the hydrogenation of (hetero)arenes as they proceed efficiently in mild reaction conditions. In this work, a series of Ru based materials was used in order to selectively hydrogenate quinaldine and assess the impact of the stabilizing agent on their catalytic performances. Ru nanoparticles stabilized with polyvinylpyrrolidone (PVP) and 1‐adamantanecarboxylic acid (AdCOOH) allowed to obtain 5,6,7,8‐tetrahydroquinaldine with a remarkable selectivity in mild reaction conditions by choosing the suitable solvent. The presence of a carboxylate ligand on the surface of the Ru NP led to an increase in the activity when compared to Ru/PVP catalyst. The stabilizing agent had also an impact on the selectivity, as carboxylate ligand modified catalysts promoted the selectivity towards 1,2,3,4‐tetrahydroquinaldine, with bulky carboxylate displaying the highest ones.