bluuebunny/crossref_metadata_2025_split huggingface dataset:
HPV16 E6 promoting cervical cancer progression through down‐regulation of miR‐320a to increase TOP2A expression
Authors: Zhang Jianing , Yu Xiaohui , Guo Yi , Wang Daqing 
Published: January 2024

AbstractBackgroundCervical cancer (CC) has become the fourth most common cancer worldwide and it is mainly caused by the infection of human papillomavirus (HPV), especially high‐risk HPV16. Aberrant miRNA expression in CC is closely related to HPV16 infection, and the regulation of HPV16 E6 expression can affect a variety of miRNA expression. This study aims to exploring the miRNAs involved in E6 regulation in CC.MethodsOur study screened differentially expressed miRNAs in cervical cells of HPV16 infected and uninfected cervical cancer patients by analyzing the GSE81137 dataset of the gene expression omnibus database (GEO), and identified miR‐320a that plays an anti‐tumor role and is associated with good prognosis of cervical cancer. Explore the effect of HPV16 E6 on the expression of miR‐320a in cervical cancer, and verify whether HPV16 E6 regulates the downstream target gene TOP2A expression through miR‐320a, thereby affecting cervical cancer cell proliferation, apoptosis, migration, invasion, and EMT in vitro and in vivo.ResultsThe bioinformatic methods selected the miR‐320a, which was differentially expressed in cervical cells from HPV16‐infected patients compared to uninfected patients. We further demonstrated that miR‐320a level was regulated by HPV16 E6, which promoted the CC cell proliferation, migration, invasion, and inhibited apoptosis. In addition, we predicted the downstream target genes of miR‐320a and confirmed that TOP2A was one of its targeting proteins. Moreover, HPV16 E6 promoted the TOP2A expression in CC cells through down‐regulating miR‐320a, leading to promoting CC development.ConclusionsWe confirmed that HPV16 E6 promoted the TOP2A expression through down‐regulation of miR‐320a, thus promoting CC development, and the HPV16 E6/miR‐320a/TOP2A axis may perform as a potential target for CC treatment.
The impact of height and weight on rescreening rates within a population‐based breast screening program
Authors: Pirikahu Sarah , Darcey Ellie , Lund Helen , Wylie Elizabeth , Stone Jennifer 
Published: January 2024

AbstractIntroductionWomen with obesity are at increased risk of post‐menopausal breast cancer and less likely to participate in breast screening. This study investigates the impact of asking women their height and weight within a population‐based screening program, and the association of BMI with rescreening status.MethodsData regarding 666,130 screening events from 318,198 women aged 50–74 attending BreastScreen Western Australia between 2016 and 2021 were used to compare crude and age‐standardised rescreening rates over time. Mixed effects logistic regression was used to investigate associations of BMI with rescreening status.ResultsRescreening rates for women screened since 2016 were within 1.8% points from the previous reporting period, stratified by screening round. Increasing BMI was associated with decreased likelihood of returning to breast screening (OR = 0.993, 95% CI: 0.988–0.998; OR = 0.989, 95% CI: 0.984–0.994; OR = 0.985, 95% CI: 0.982–0.987 for women screening for the first, second and third+ time, respectively).ConclusionsThis large, prospective study supports implementation of routine height and weight collection within breast screening programs. It shows that asking women their height and weight does not deter them from returning to screening and that women with increased BMI are less likely to rescreen, highlighting a need for targeted interventions to improve screening barriers for women living with obesity.
Green Emission of Erbium Doped SYW Phosphors for Optical Thermometry And Solid‐State Lighting
Authors: Kumari Sheetal , Rao A. S. , Sinha R. K. 
Published: January 2024

AbstractA series of Er3+ ions doped Sr9Y2W4O24 (SYW) phosphors have been synthesised using solid‐state reaction technique. For optical thermometry and solid state lighting applications, the crystal structure, morphological, and luminescence features of the SYW : Er3+ phosphors were explored. X‐ray diffraction (XRD) reveal that synthesized phosphors having single phase with a tetragonal crystal structure and I41/a space group. Scanning electron microscopy (SEM) was used to examine the morphological behaviour and presence of composition elements. The optical bandgap of the phosphor was evaluated using UV‐Vis diffuse reflection spectra (DRS). The photoluminescence (PL) emission spectra were captured under 380 nm excitation, and the peak with the maximum intensity was identified at 563 nm ascribed to transition 4S3/2→4I15/2, that emits green color in visible region. The temperature dependent PL (TD‐PL) spectra show that SYW phosphor is substantially more thermally stable, having thermal activation energy of about 0.247 eV. Additionally, the fluorescence intensity ratio (FIR) was used to study the optical sensing characteristics of the thermal quenching transitions (2H11/2, 4S3/2) with maximum relative sensitivity (SR) and an absolute sensitivity (SA) being 1.33 % K−1and 0.307 % K−1, respectively. All of the aforementioned findings demonstrate that SYW : Er3+ ions doped phosphors have potential for optical thermometry and other photonic devices.
N,N‐Dimethyl Formamide European Restriction Demands Solvent Substitution in Research and Development
Authors: Sherwood James , Albericio Fernando , de la Torre Beatriz G. 
Published: January 2024

AbstractAs of December 2023, the use of common solvent N,N‐dimethyl formamide (DMF) will be restricted in the European Union because of its reproductive health hazard. Industrial facilities must comply with stricter exposure limits, and researchers are recommended to find alternative solvents. Here we explain the restrictions on DMF, which disciplines are affected, and how to substitute DMF to keep research and development commercially relevant.
Catalytic Cleavage of the C−O Bonds in Lignin and Lignin Model Compounds by Metal Triflate Catalysts
Authors: Zhu Rui , Mao Changtao , Gao Fang , Guo Zhongpeng , Li Moying , Xin Yu , Gu Zhenghua , Zhang Liang 
Published: January 2024

AbstractThe effective cleavage of C−O bonds in linkages of lignin was one of the significant strategies promoting lignin valorization. Herein, the strategy of C−O bonds cleavage of lignin using metal triflate as the catalyst was developed. The carboxylic acid or alcohol could be used as the nucleophile to stabilize the reactive intermediates formed during the depolymerization of lignin, and the corresponding ester/ether compounds could be obtained. This catalytic system was suitable for the C−O bond cleavage in α‐O‐4 and β‐O‐4 linkages with excellent efficiency. Additionally, reaction conditions were optimized. The reaction mixture was detected by 1H NMR, and no other byproducts were found. As for treated lignin samples, the cleavage of C−O bonds in linkages was determined by 2D HSQC NMR, the increased content of the phenol hydroxyl group was proved by FT‐IR, and the reduced molecular weight was investigated by GPC. Furthermore, multiple phenolic compounds were detected by GC‐MS in the reaction mixtures.
A simplified model and its parameters optimization methodology of LCC‐S WPT compensation network under dual‐side‐detuned conditions
Authors: Li Zhizhong , Han Fei , Zhang Guidong 
Published: January 2024

AbstractWireless power transfer (WPT) systems typically operate under broad coupling conditions. In response to the issue of significant fluctuations in output power due to changes in the coupling coefficient when the coupling coils are offset, this paper proposes a parameter design method for the LCC‐S topology that remains applicable under dual‐side‐detuned conditions. Presented the design principles of the dual‐side‐detuned circuit, and an iterative approach is employed to guide the parameter design process. It also introduced a method for selecting the rated coupling coefficient to minimize power fluctuations within the expected range. Experimental validation demonstrates that the robustness and resistance to coupling coefficient fluctuations of the proposed dual‐side‐detuned LCC‐S topology surpass those of other candidate schemes. Within a coupling variation range from 0.23 to 0.35, the maximum fluctuation rate of the output power remains below 6% while maintaining acceptable efficiency. This design has relevance to typical application scenarios.
In Situ Assembly of a Metal‐Templated Catalyst for Asymmetric Aldol Reactions: From the Metal Complexes Equilibria to a Practical System
Authors: Jimeno Ciril , Solà Jordi , Alfonso Ignacio 
Published: January 2024

AbstractA zinc(II)‐templated catalyst assembling terpyridine and bipyridine organocatalytic ligands has been developed for the asymmetric aldol reaction. The system has been optimized to maximize the formation of the heteromeric bifunctional species through the determination of the equilibrium constants leading to the formation of all the species present. A practical, easy to synthesize catalytic system providing high stereoselectivity has been achieved in this way.
Mobilization of shared victimhood in the radical right populist Finns Party supporters’ identity work: A narrative–discursive approach to populist support
Authors: Rovamo Helena , Sakki Inari 
Published: January 2024

AbstractIn the 21st century, populist leaders have created and shaped narratives of threatened nations to foster a sense of shared victimhood and increase electoral appeal. However, an intriguing question has emerged: What roles do these outlined populist discourses of a threatened nation and shared victimhood play in the identity work of populist supporters? This study employs a narrative–discursive approach to analyse 25 in‐depth interviews with radical right populist Finns Party supporters. We investigate how the supporters construct and utilize populist discourses and narratives of lived experiences to legitimize their political support for the Finns Party. Furthermore, we illustrate how the related subject positions enable populist supporters to reproduce and enhance the populist discourse of ‘people's’ victimhood through the actions of ‘others’. This study contributes to the field by demonstrating how populist discourses and narratives of lived experiences can be mobilized into political support for the Finns Party.
A core outcome set for patient‐reported dysphagia for use in head and neck cancer clinical trials: An international multistakeholder Delphi study
Authors: Manduchi Beatrice , Fitch Margaret I. , Ringash Jolie G. , Howell Doris , Martino Rosemary 
Published: January 2024

AbstractBackgroundMeasuring dysphagia‐related patient‐reported outcomes (PROs) in Head and Neck Cancer (HNC) patients is challenging due to dysphagia's multidimensional impact, causing inconsistency in outcome reporting. To address this issue, this study derived a consensus‐based core outcome set (COS) for patient‐reported dysphagia in HNC clinical trials where swallowing is a primary or secondary endpoint.MethodsA sample of HNC clinicians, researchers, patients, and caregivers participated in a 2‐Round Delphi technique. A Delphi survey, containing a comprehensive list of dysphagia‐related PROs, was developed. In Round 1, participants rated item importance on a 5‐point scale. Items rated ≥4 by >70% advanced to Round 2, where a consensus meeting addressed items with varied opinions, and the Delphi survey with remaining items was completed. Items rated ≥4 by >70% formed the final COS.ResultsForty‐five participants from nine countries were recruited. After Round 1, 40 items were excluded and 64 advanced to Round 2. After Round 2, a 7‐outcome COS was established, comprising the domains of dysphagia symptoms, health status and quality of life.ConclusionThis study achieved consensus among HNC stakeholders on essential dysphagia PROs for HNC clinical trials. It is advisable to include these 7‐core concepts in clinical trials involving people with HNC to facilitate treatment comparisons and data synthesis.
Dexamethasone eluting polydopaminated polycaprolactone‐poly (lactic‐co‐glycolic) acid for treatment of tracheal stenosis
Authors: Morand Jacob , McClellan Phillip , Isali Ilaha , Dikici Yusuf , Fan Di , Li Longshun , Shoffstall Andrew J. , Akkus Ozan , Weidenbecher Mark 
Published: January 2024

AbstractTracheal stenosis is commonly caused by injury, resulting in inflammation and fibrosis. Inhibiting inflammation and promoting epithelization can reduce recurrence after initial successful treatment of tracheal stenosis. Steroids play an important role in tracheal stenosis management. This study in vitro evaluated effectiveness of a polydopaminated polycaprolactone stent coated with dexamethasone‐eluting poly(lactic‐co‐glycolic) acid microparticles (μPLGA) for tracheal stenosis management. Polydopamination was characterized by Raman spectroscopy and promoted epithelialization while dexamethasone delivery reduced macrophage activity, assessed by individual cell area measurements and immunofluorescent staining for inducible nitric oxide synthase (iNOS). Dexamethasone release was quantified by high‐performance liquid chromatography over 30 days. Activation‐related increase in cell area and iNOS production by RAW 264.7 were both reduced significantly (p < .05) through dexamethasone release. Epithelial cell spreading was higher on polydopaminated polycaprolactone (PCL) than PCL‐alone (p < .05). Force required for stent migration was measured by pullout tests of PCL‐μPLGA stents from cadaveric rabbit and porcine tracheas (0.425 ± 0.068 N and 1.082 ± 0.064 N, respectively) were above forces estimated to occur during forced respiration. Biomechanical support provided by stents to prevent airway collapse was assessed by comparing compressive circumferential stiffness, and stiffness of the stent was about 1/10th of the rabbit trachea (0.156 ± 0.023 N/mm vs. 1.420 ± 0.194 N/mm, respectively). A dexamethasone‐loaded PCL‐μPLGA stent platform can deliver dexamethasone and exhibits sufficient mechanical properties to anchor within the trachea and polydopamination of PCL is conducive to epithelial layer formation. Therefore, a polydopaminated PCL‐μPLGA stent is a promising candidate for in vivo evaluation for treatment of tracheal restenosis.
2‐Aminopyrazine catalyzed three‐component and one‐pot construction of 2‐amino‐4H‐chromene‐3‐carbonitrile by mortar‐pestle grinding and molecular docking studies
Authors: Edapu Harish Kumar , Boodida Sathyanarayana , Pagadala Ramakanth , Damera Thirupathi 
Published: January 2024

AbstractA highly efficient and environmentally friendly method for the synthesis of 2‐amino‐4H‐chromene‐3‐carbonitrile (ACC) derivatives has been successfully established. This innovative, solvent‐free approach involves a tandem three‐component and one‐pot reaction utilizing arylaldehyde, dicyanomethane, and dimedone/cyclohexane‐1,3‐dione, catalyzed by 2‐aminopyrazine under the mortar‐pestle grinding technique. Key attributes of this synthetic strategy include its simplicity, high efficiency, cost‐effectiveness, absence of column chromatography, shorter reaction times (18–40 min), and consistently high yields (89%–96%). Furthermore, computational studies have been conducted against the 4RHT protein using the synthesized compounds.
Investigating the relationship between quantitative‐based ultrasound and MRI estimations of rotator cuff fatty infiltration
Authors: Mahna Alexandra , Boulanger Stephen M. , Gatti Anthony A. , Alenabi Talia , Ku Austin , Hynes Loriann M. , Chopp‐Hurley Jaclyn N. 
Published: January 2024

AbstractIntroductionFatty infiltration (FI) of the rotator cuff has important clinical implications. Quantitatively estimating FI using ultrasound (US) has considerable benefits for assessing FI in a non‐invasive, accessible manner. This research investigated whether FI of the supraspinatus (SS) and infraspinatus (IS), estimated using US was related to intramuscular fat fractions measured from magnetic resonance images (MRI).MethodsData from 12 healthy young adult participants were used for analysis. US images of the SS and IS were captured using multiple transducer placement techniques from which echogenicity of the muscle region was quantified. Shoulder MRI were captured from which SS and IS were manually segmented and intramuscular fat fractions calculated. Six upper limb strength exertions were performed, resisted by a hand dynamometer.ResultsIS and SS echogenicity explained a significant amount of variance in MRI fat fractions for certain body positions and transducer techniques. Echogenicity agreement was higher for IS than SS. Significant relationships were identified between strength exertions and both echogenicity and MRI muscle volume, but not MRI fat fraction.ConclusionsThis research provides preliminary evidence showing that quantitative‐based US methods can be used to estimate MRI calculated fat fractions for the rotator cuff.
Non‐Hodgkin lymphoma in a kidney transplanted patient with methylmalonic acidemia: Metabolic susceptibility and the role of immunosuppression
Authors: Burlina Alberto B. , Burlina Alessandro P. , Mignani Renzo , Cazzorla Chiara , Gueraldi Daniela , Puma Andrea , Loro Christian , Baumgartner Matthias R. , Gragnaniello Vincenza 
Published: January 2024

AbstractMethylmalonic acidemia cblB type (MMA cblB) is an autosomal recessive inborn error of amino acid metabolism that results in impaired synthesis of adenosylcobalamin, a cofactor of methylmalonyl‐CoA mutase. It presents with episodes of coma, vomiting, hypotonia, metabolic acidosis, and hyperammonemia. End‐stage kidney disease is a long‐term complication. Treatments include vitamin B12 supplementation, L‐carnitine, and a low‐protein diet. Liver, kidney, or combined liver‐kidney transplantations are promising options, but they are not without complications. We report a patient suffering from MMA cblB who developed end‐stage kidney disease at 18 years of age. Kidney transplantation allowed him to recover normal kidney function and good metabolic control. Unfortunately, after two decades, he developed non‐Hodgkin lymphoma and severe chemotherapy toxicity which led to his death. The risk of lymphoproliferative diseases is known to increase after solid organ transplantation. However, in MMA, factors including mitochondrial dysfunction and oncometabolites, may further increase the risk of malignancy and drug toxicity. Our report highlights the importance of considering the increased risk of cancer in long‐term follow‐up of MMA cblB patients, especially after solid organ transplantation. Moreover, when chemotherapy is needed, the increased risk of toxicity and metabolic decompensation should be considered and monitored.
Supply chain representation on the board of directors and firm performance: A balance of relational rents and agency costs
Authors: Barker Jordan M. , Hofer Christian , Dobrzykowski David D. 
Published: January 2024

AbstractAppointing individuals drawn from suppliers and customers to a firm's board of directors is an increasingly popular practice that can enhance the interorganizational relationship and generate relational rents. Yet, such board members may act in the best interest of their primary employer rather than the shareholders of the firm whose board they serve on, thus creating potential agency conflicts. Drawing on the relational view and agency theory, we explore the tension between rent generation and agency costs and consider how a firm can design governance mechanisms to effectively leverage customer or supplier representation on the board of directors. The associated hypotheses are tested using a large panel dataset constructed from multiple archival sources, and our findings suggest that supplier and customer board members are a double‐edged sword: While they generate value in some instances, they can also be associated with lower performance depending on the levels of two key governance mechanisms—the number of inside directors on the board and the proportion of outcome‐based board member compensation.
Efficacy of Ultrasound‐Guided Tendon Release for Trigger Finger Compared With Open Surgery
Authors: Amro Sarah , Kashbour Muataz , Shaaban Abdelgalil Mahmoud , Qafesha Ruaa Mustafa , Eldeeb Hatem 
Published: January 2024

BackgroundTrigger finger (also known as stenosing tenosynovitis) is a chronic inflammatory disorder that affects the fingers and causes discomfort and functional impairment. It is estimated to affect 2–3.6% of the population and is more common in manual laborers and individuals engaged in repetitive hand activities. This study comprehensively compares the efficacy of ultrasound‐guided release versus traditional open surgery in treating trigger fingers.MaterialsWe systematically searched PubMed, Scopus, EMBASE, and the Cochrane Library to identify relevant studies. Inclusion criteria were studies evaluating ultrasound‐guided release of trigger finger (grade 2 and higher) compared with open surgical release. A meta‐analysis was performed by Revman software 5.4.1 to assess efficacy, utilizing appropriate statistical methods to address heterogeneity. Primary outcome measures included “Quick Disability of Arm, Shoulder, and Hand” (QDASH) scores, Grip strength, and the Visual Analogue Scale (VAS). Secondary outcome measures included Days of stopping analgesia, full‐digit flexion and extension, days to return to normal activities, pinch strength, Quinnell grading score, and bow strengthening.ResultsOut of the initial pool of 820 studies, five met the inclusion criteria, including 275 patients with 283 trigger digits. The analysis revealed significant differences favoring the ultrasound‐guided release group over the surgical group for improvement in Quick Disability of Arm, Shoulder, and Hand score in the first month (MD −0.48, 95% CI: 0.75 to −0.2, P = .0007, I2 = 20%). The difference was not statistically significant in the 3‐month follow‐up period (MD −2.25, 95% CI: −0.54 to 0.05, P = .1, I2 = 0%). Additionally, there is a significant difference in the days required for return to normal activities in favor of the ultrasound release approach (MD −13.78, 95% CI: −16.68 to 10.89, P = .00001, I2 = 68%). The data displayed heterogeneity, which was resolved through sensitivity analysis that also favored the ultrasound‐guided group. In terms of grip strength, full‐digit flexion and extension, VAS, and days of stopping analgesia no significant differences were observed.ConclusionsUltrasound‐guided release showed advantages over open surgical release, resulting in improved QDASH score and quicker return to normal activities. This offers a minimally invasive, successful alternative to open surgery, reducing associated risks. Further studies with long‐term follow‐up are recommended.