bluuebunny/crossref_metadata_2025_split huggingface dataset:
Makna Kultural pada Kepercayaan Masyarakat Jawa Terhadap Ketupat di Momen Lebaran: Kajian Antropologi Linguistik
Authors: Maghfiroh Alvina , Nurhayati Nurhayati 
Published: October 2023

Ketupat pada momen lebaran memberikan makna tersendiri bagi masyarakat Jawa. Mereka memiliki kepercayaan tertentu dalam memaknai ketupat, khususnya mengenai filosofi maupun proses pembuatannya. Penelitian ini bertujuan untuk mengungkapkan makna kultural di balik kepercayaan mengenai ketupat serta nilai-nilai kearifan lokal yang terkandung di dalamnya. Penelitian ini menggunakan metode kualitatif yang pengumpulan datanya menggunakan wawancara mendalam. Dengan menggunakan pendekatan antropologi linguistik, data penelitian ini dianalisis secara induktif dan menggunakan metode analisis padan translasional. Temuan penelitian menunjukkan adanya 3 pamali, 6 keyakinan, dan 3 syarat yang sampai sekarang ini masih dipercayai oleh masyarakat Jawa mengenai ketupat. Hasil penelitian mengimplikasikan adanya nilai-nilai kearifan lokal, seperti keharusan untuk melestarikan budaya Jawa, menganut prinsip minimalis, dan konsep animisme dan dinamisme yang mendominasi kepercayaan tersebut. Meskipun demikian, mereka hanya mengikuti ajaran nenek moyang tanpa bermaksud untuk melakukan praktik animisme dan dinamisme yang bertentangan dengan syariat Islam.
Ocorrência da síndrome de ansiedade e separação em cães atendidos em hospital veterinário no município de Itajaí, Santa Catarina
Authors: Guollo Ana Júlia , Bako Erica Perez Marson , Piani Stephanie Simonetto 
Published: October 2023

The adoption of anthropomorphized treatments in dogs, in addition to factors such as environment and social life, generate disturbances and behavioral changes, favoring situations of frustration and anxiety, evolving into Separation Anxiety Disorder (SAD), a type of multifactorial behavioral disorder characterized by a set of classic behavioral responses, such as excessive vocalization, destructive behaviors, and urination and defecation disorders. Another commonly reported behavior is hyper-attachment, an extreme affective attachment of the dog to its owner. This research aims to evaluate the occurrence of separation anxiety in dogs treated at a Veterinary Hospital through questionnaires applied to tutors. The answers obtained were evaluated by performing the chi-square test using the Jamovi software. As affirmation criteria, we selected the animals that had any typical clinical signs, and also those that showed hyper-attachment behaviors, which may or may not be concomitantly associated with signs of depression. Of the evaluated animals, 68.5% had SAD, 22% had excessive vocalization and 29.6% had destructive behaviors. In regards to hyper-attachment, about 59.2% of the animals followed the tutor around the house, and 57.4% and 37% exhibited warm and exaggerated celebratory behaviors, respectively, whenever the tutor returned home - all signs of hyper-attachment associated with depressive behaviors. SAD is a problem that has an impact on the quality of life of the animal and also of those who live with it. In this study, it was concluded that most dogs had an occurrence of SAD, and the most frequent clinical signs were the presence of vocalization, destructive behaviors and inappropriate eliminations, in addition to behaviors that denote hyper-attachment associated with departure and arrival rituals of the tutor. In addition, the study also suggests the need to use questions directed to each case, in order to obtain a reliable diagnosis.
Hadhramaut Arabs in the Malay World: Features of Naturalization and Social Status
Authors: Goriaeva Liubov 
Published: October 2023

In island Southeast Asia, since the first centuries of the Muslim era, the Hadhramaut Arab diaspora has been steadily present. Arabs controlled maritime trade south of the Arabian Peninsula since pre-Islamic times. They have long traded with India, and sometimes sailed even further to their cherished goal - the Spice Islands (Moluccas).
With the advent of Islam, the presence of Arabs in the ports of the Archipelago increased and was generally perceived positively: they acted as bearers and preachers of the new religion. Over time, their business contacts with the local merchant community grew stronger. The most powerful influx of Arabs to Nusantara dates back to the beginning of the 18th century. Subsequently, with the opening of the Suez Canal (1869), this process gained even greater scope.

Over the years, the aliens, step by step, won a place for themselves in the field of commerce, in agriculture and shipbuilding, Islamic preaching and diplomacy, education and politics. Some of them laid the foundation for new Malay dynasties (the sultanates of Siak and Kalimantan, 18th century) or simply entered the circle close to local rulers. Since the beginning of the twentieth century Arab merchants participate in the organization of the first political parties in Indonesia. The paper briefly examines the biographies of some members of the Hadhramaut aristocracy, Sayyids and Sharifs, who took a prominent place in the cultural, economic and political life of Malaysia and Indonesia in the pre-colonial and post-colonial era.
Why was The Cult of Arsinoë II Philadelphus established in Egyptian Temples?
Authors: Apenko Mikhail 
Published: October 2023

The cult of Arsinoë II Philadelphus is considered one of the most significant cults in Hellenistic Egypt. It originated from the Greek oriented cult of Theoi-Adelphoi after Arsinoë’s death and soon became a vital part of both Greek and Egyptian religious life. What is even more important, Arsinoë became the first member of Ptolemaic dynasty to receive such a cult in Egyptian temples. Yet we still do not quite understand why was it so prominently established there. This article proposes a possible answer to this question. Based on the information from Sais inscription, a source from the reign of Ptolemy II, we can conclude that the main reason for the spread of the cult of Arsinoë in Egyptian temples was the natural conditions that developed in Egypt in the mid-260s. BCE. The text mentions a certain deficiency of the land during the king’s visit to Sais in 265/64 BCE. It seems that at this time Egypt faced low floods of the Nile, which could possibly lead to a lack of crops throughout the country. This in turn could threaten the legitimacy of Ptolemy II, who, as a king of Egypt, was viewed as the one responsible for the floods of the Nile river. Thus an event like this could become a cause for major instability in society or even a revolt. Under these circumstances the cult of Arsinoë II Philadelphus was used to promote royal legitimacy and bind part of the Egyptian priesthood to the ruling house of the Ptolemies.
DRAGON AND GODDESS: THE CULT OF GODDESS SARASWATI IN JAPAN
Authors: Lepekhova Elena 
Published: October 2023

This study is devoted to the cult of goddess Benzaiten (Saraswati) in Japan. As an Indian goddess Saraswati, who in the Vedic period was revered as the deity of the river of the same name, under the influence of Hinduism and Buddhism turned into the patroness of music and the embodiment of eloquence. In the Far East, China and Japan, she was known as Biancaitian (Jp. Benzaiten). However, in addition to her connection with music, Benzaiten retained the association with water inherent in the original Saraswati, which was expressed in her veneration as a goddess incarnated in a water deity-dragon or commanding them. At the same time, due to the ambivalence of her nature, ambiguously interpreted in various Buddhist sources, Benzaiten turned into a universal deity, identified with many other gods from the Shinto-Buddhist pantheon. For this reason, later she took a firm place in Japanese folklore, being included among the Seven Gods of Happiness (Jp. Shichifukujin). Based on a comparative analysis, it is concluded that if the deity of the Saraswati River in the Rig Veda is a stormy, water element that cannot be controlled, but can only be propitiated with hymns and offerings, then the Japanese Benzaiten, which sometimes manifests itself in the form of an unbridled dragon or snake, can be subjugated through the Buddhist rituals. This fact shows the importance of Buddhism in fixing religious cultural codes that originated in ancient India, and their subsequent spread across the territory of Central Asia and the Far East.
PUNGUTAN LIAR PADA PENYELENGGARA PENDIDIKAN DASAR DALAM PERSPEKTIF BUDAYA HUKUM
Authors: Rohaya Yoyo , Sumiati Dede , Komalasari Cicik 
Published: October 2023

Dana Bantuan Operasional Satuan Pendidikan (BOSP) merupakan dana alokasi khusus nonfisik untuk mendukung biaya operasional nonpersonalia bagi Satuan Pendidikan, namun meskipun adanya BOSP. Implementasi pelaksanaan penyelenggaraan pendidikan yang melahirkan luaran yang berbudipekerti dan yang dalam pelaksanaannya tidak anak lepas dari perilaku pungutan liar. Metode penelitian yang digunakan dalam penelitian ini adalah deskriptif analisis dan pendekatan penelitian ini meggunakan pendekatan yuridis empiris atau disebut juga penelitian hukum sosiologis, yaitu mengkaji ketentuan hukum yang berlaku serta apa yang terjadi dalam kenyataannya di masyarakat. Penelitian hukum sosiologis merupakan penelitian terhadap identifikasi hukum dan efektifitas hukum dalam dinamika sosial kemasyarakatan. Untuk itu hukum seringkali dikaitkan dengan dinamika kemasyarakatan yang sedang dan akan terjadi. Setelah data sekunder dan primer terkumpul, selanjutnuya dilakukan analisis secara kualitatif. Menurut dari hasil penelitian serta data analytic, disimpulkan bahwa sekolah atau komite sekolah mengemas pungutan liar tersebut seakan-akan berdasarkan pada perjanjian kesepakatan antar pihak di sekolah, komite sekolah, dan orangtua atau wali murid, namun pungutan liar yang terjadi di penyelenggara pendidikan dasar berdasarkan perspektif budaya hukum bertentangan dengan kesusilaan, kepatutan, kepentingan umum dan subtansi hukum positif dan pungutan liar dalam perspektif budaya hukum, akan dapat dicegah atau hilang tergantung pada budaya hukum penyelenggara pendidikan tersebut.
Prognostic value of blood-based protein biomarkers in non-small cell lung cancer: A critical review and 2008–2022 update
Authors: Trulson Inga , Holdenrieder Stefan 
Published: October 2023

BACKGROUND: Therapeutic possibilities for non-small cell lung cancer (NSCLC) have considerably increased during recent decades. OBJECTIVE: To summarize the prognostic relevance of serum tumor markers (STM) for early and late-stage NSCLC patients treated with classical chemotherapies, novel targeted and immune therapies. METHODS: A PubMed database search was conducted for prognostic studies on carcinoembryonic antigen (CEA), cytokeratin-19 fragment (CYFRA 21-1), neuron-specific enolase, squamous-cell carcinoma antigen, progastrin-releasing-peptide, CA125, CA 19-9 and CA 15-3 STMs in NSCLC patients published from 2008 until June 2022. RESULTS: Out of 1069 studies, 141 were identified as meeting the inclusion criteria. A considerable heterogeneity regarding design, patient number, analytical and statistical methods was observed. High pretherapeutic CYFRA 21-1 levels and insufficient decreases indicated unfavorable prognosis in many studies on NSCLC patients treated with chemo-, targeted and immunotherapies or their combinations in early and advanced stages. Similar results were seen for CEA in chemotherapy, however, high pretherapeutic levels were sometimes favorable in targeted therapies. CA125 is a promising prognostic marker in patients treated with immunotherapies. Combinations of STMs further increased the prognostic value over single markers. CONCLUSION: Protein STMs, especially CYFRA 21-1, have prognostic potential in early and advanced stage NSCLC. For future STM investigations, better adherence to comparable study designs, analytical methods, outcome measures and statistical evaluation standards is recommended.
A rise in the frequency of lasR mutant Pseudomonas aeruginosa among keratitis isolates between 1993 and 2021
Authors: Shanks Robert M. Q. , Atta Sarah , Stella Nicholas A. , Sundar-Raj Chollapadi V. , Romanowski John E. , Grewal Arman S. , Shanks Hazel Q. , Mumper Sonya M. , Dhaliwal Deepinder K. , Mammen Alex , Callaghan Jake D. , Calvario Rachel C. , Romanowski Eric G. , Kowalski Regis P. , Zegans Michael E. , Jhanji Vishal 
Published: October 2023

IntroductionPseudomonas aeruginosa causes vision threatening keratitis. The LasR transcription factor regulates virulence factors in response to the quorum sensing molecule N-3-oxo-dodecanoyl-L-homoserine lactone. P. aeruginosa isolates with lasR mutations are characterized by an iridescent high sheen phenotype caused by a build-up of 2-heptyl-4-quinolone. A previous study demonstrated 22% (n=101) of P. aeruginosa keratitis isolates from India between 2010 and 2016 were sheen positive lasR mutants, and the sheen phenotype correlated with worse clinical outcomes for patients. In this study, a longitudinal collection of P. aeruginosa keratitis isolates from Eastern North America were screened for lasR mutations by the sheen phenotype and sequencing of the lasR gene.MethodsKeratitis isolates (n=399) were classified by sheen phenotype. The lasR gene was cloned from a subset of isolates, sequenced, and tested for loss of function or dominant-negative status based on an azocasein protease assay. A retrospective chart review compared outcomes of keratitis patients infected by sheen positive and negative isolates.ResultsA significant increase in sheen positive isolates was observed between 1993 and 2021. Extracellular protease activity was reduced among the sheen positive isolates and a defined lasR mutant. Cloned lasR alleles from the sheen positive isolates were loss of function or dominant negative and differed in sequence from previously reported ocular lasR mutant alleles. Retrospective analysis of patient information suggested significantly better visual outcomes for patients infected by sheen positive isolates.DiscussionThese results indicate an increase in lasR mutations among keratitis isolates in the United States and suggest that endemic lasR mutants can cause keratitis.
Identification of risk factors for hypertension in overweight and obese people and analysis of risk factor interactions: an R-based analysis
Authors: Li LuWei , Cheng SiShuai , Xu GuoQuan 
Published: October 2023

ObjectiveThis study identified the independent risk factors for hypertension in overweight and obese people and also analyzed the interaction between the risk factors.MethodsA total of 5,098 overweight and obese people were enrolled in this study. First, the clinical metabolic characteristics of hypertension and control groups were compared. The logistic regression (LR) and classification and regression trees (CRT)-based decision tree (DT) models were used to screen the independent risk factors for hypertension in overweight and obese people. The multiplicative and additive scale analyses were used to analyze the two risk factors with interaction from the perspective of statistics and biological interaction. Finally, the receiver operating characteristic (ROC) and calibration curves were used to analyze the accuracy and identification ability of the LR and DT models.ResultsAge, UA, FPG, SBP, Cr, AST, TG, and FPG were higher in the hypertension group than in the control group (P &lt; 0.05). The results of LR revealed that NAFLD, FPG, age, TG, LDL-c, UA, and Cr were positively correlated with hypertension in overweight and obese people, and GFR was negatively correlated with hypertension in overweight and obese people (P &lt; 0.05). The DT model suggested that the risk factors of age, FPG, and UA interacted with each other. The multiplicative single and multiple factor analysis for FPG + UA, age + UA, age + FPG revealed a positive multiplicative interaction (P &lt; 0.05, B ≠ 0, OR &gt; 1). The additive single and multiple factor analysis for age + UA indicated a positive additive interaction. The ROC and calibration curve analysis indicated that the CRT decision tree, FPG + UA, age + UA, and age + FPG have certain accuracy and discrimination ability.ConclusionThe independent risk factors for hypertension in overweight and obese people included NAFLD, FPG, age, TG, LDL-c, UA, and Cr. Among these, age + UA exhibited synergistic interaction, thereby providing a reference for the prevention and control of hypertension in overweight and obese people.
Serum YKL-40 in coronary heart disease: linkage with inflammatory cytokines, artery stenosis, and optimal cut-off value for estimating major adverse cardiovascular events
Authors: Song Mowei , Zhang Guofu , Shi Hang , Zhu Erjun , Deng Li , Shen Hongtao 
Published: October 2023

ObjectiveYKL-40, previously known as chitinase-3-like protein 1 (CHI3L1), is an inflammation-related glycoprotein that promotes atherosclerosis, but its application and optimal cut-off value as a prognostic biomarker in coronary heart disease (CHD) require more clinical evidence. Thus, this prospective study aimed to evaluate the linkage of serum YKL-40 with disease features, inflammatory cytokines, and major adverse cardiovascular events (MACEs) in CHD patients.MethodsA total of 410 CHD patients were enrolled for serum YKL-40 determination via enzyme-linked immunosorbent assay. Meanwhile, serum YKL-40 levels in 100 healthy controls (HCs) were also quantified.ResultsYKL-40 level was higher in CHD patients compared with that in HCs (P &lt; 0.001). YKL-40 was positively linked with hyperlipidemia (P = 0.014), diabetes mellitus (P = 0.001), fasting blood glucose (P = 0.045), C-reactive protein (P &lt; 0.001), the Gensini score (P &lt; 0.001), and stenosis degree (graded by the Gensini score) (P &lt; 0.001) in CHD patients. In addition, an elevated YKL-40 level was associated with increased levels of tumor necrosis factor alpha (P = 0.001), interleukin (IL)-1β (P = 0.001), IL-6 (P &lt; 0.001), and IL-17A (P = 0.002) in CHD patients. The 1-/2-/3-year cumulative MACE rates of CHD patients were 5.5%, 14.4%, and 25.0%, respectively. Regarding the prognostic capability, YKL-40 ≥100 ng/ml (the median cut-off value) (P = 0.003) and YKL-40 ≥150 ng/ml (the third interquartile cut-off value) (P = 0.021) reflected an elevated accumulating MACE rate, whereas accumulating MACE was not different between CHD patients with YKL-40 ≥80 and &lt;80 ng/ml (the first interquartile cut-off value) (P = 0.083).ConclusionSerum YKL-40 is positively linked with inflammatory cytokines and the Gensini score, whose high expression cut-off by 100 and 150 ng/ml estimates a higher MACE risk in CHD patients.
Safety and efficacy of immune checkpoint inhibitor cancer therapy in patients with preexisting type 1 diabetes mellitus
Authors: Hilder Robin , Tsai Karen , Quandt Zoe , Isaacs Dayna , Drakaki Alexandra , Xing Yan , In Gino K. , Angell Trevor E. , Lechner Melissa G. 
Published: October 2023

IntroductionImmune checkpoint inhibitors (ICI) produce dramatic tumor shrinkage and durable responses in many advanced malignancies, but their use is limited by the development of immune-related adverse events (IRAEs) that occur in up to 60% of patients and often affect endocrine organs. Concern for more severe IRAEs in patients with preexisting autoimmune diseases, including type 1 diabetes mellitus (T1DM), has led to the exclusion of such individuals from clinical trials of ICI therapy. As a result, little is known about the safety and efficacy of ICI in this population. Here, we report safety and treatments outcomes in ICI-treated patients with preexisting T1DM.MethodsThis retrospective case-controlled study evaluated adult patients with T1DM who received ICI therapy for solid malignancies from 2015 to 2021 at four academic medical centers. Patients with prior ICI therapy, bone marrow transplantation, or pregnancy were excluded. We collected data on demographics, cancer diagnosis and treatment, IRAE incidence and severity, and diabetes management. Controls were matched 2:1 by age, sex, cancer diagnosis, and ICI therapy class.ResultsOf 12,142 cancer patients treated with ICI therapy, we identified 11 with a preexisting confirmed diagnosis of T1DM prior to starting ICI therapy. Mean age was 50.6 years, 63.6% were women, and most received anti-PD1/PDL1 monotherapy (10/11) compared with combination therapy (1/11). Grade 3/4 IRAEs were seen in 3/11 subjects with preexisting T1DM and were hepatitis, myositis, and myasthenia gravis. All three cases had interruption of ICI therapy and administration of adjunct therapies, including steroids, IVIG, or mycophenolate mofetil with resolution of the IRAE. The odds of all-grade IRAEs and of severe IRAEs were comparable between cases and controls matched for age, sex, cancer type, and ICI therapy [OR 0.83 (95% CI 0.2–3.56), p = 0.81, and OR 1.69 (0.31–9.36), p = 0.55, respectively]. Overall survival was not different between patients with T1DM and controls (p = 0.54). No patients had hospitalizations for diabetes-related complications during therapy.DiscussionThese data suggest that ICI monotherapy can successfully be used in patients with preexisting T1DM, with IRAE rates comparable with individuals without preexisting T1DM. Larger, prospective studies of these potentially life-saving ICI therapies that include patients with preexisting autoimmunity are warranted.
Original delayed-start ovarian stimulation protocol with a gonadotropin-releasing hormone antagonist, medroxyprogesterone acetate, and high-dose gonadotropin for poor responders and patients with poor-quality embryos
Authors: Takeuchi Kazuhiro , Orita Yuji , Iwakawa Tokiko , Kuwatsuru Yukari , Kuroki Yuko , Fukumoto Yumiko , Mizobe Yamato , Tokudome Mari , Moewaki Harue 
Published: October 2023

IntroductionThe delayed-start gonadotropin-releasing hormone antagonist protocol seems effective for patients who are poor ovarian responders, but there are insufficient data on whether it is also effective for patients with poor-quality embryos and low rates of good blastocyst formation. Specifically, the effectiveness of delayed-start gonadotropin-releasing hormone antagonists with progesterone has not been adequately investigated. Therefore, we compared the efficacy of the original delayed-start gonadotropin-releasing hormone antagonist protocol using medroxyprogesterone acetate (MPA) and high-dose gonadotropin in patients with poor ovarian response.MethodsOverall, 156 patients with recurrent assisted reproductive technology failure who underwent the original protocol were included. They received cetrorelix acetate (3 mg) and MPA (10 mg) on cycle day 3, and high-dose gonadotropin was initiated on day 11. When the leading follicle reached 14 mm, ganirelix acetate (0.25 mg) was administered until the trigger day. The number of oocytes retrieved, metaphase II (MII) oocytes, two pronuclear (2PN) zygotes, and good blastocysts and live birth rates were compared between the previous (Cycle A) and original (Cycle B) cycles in three groups (Group A, all patients; Group B, poor responders; and Group C, patients with poor-quality embryos).ResultsIn Group A (n=156), the number of MII oocytes (3.6 ± 3.3 versus 4.5 ± 3.6), 2PN zygotes (2.8 ± 2.9 versus 3.8 ± 3.1), good blastocysts (0.5 ± 0.9 versus 1.2 ± 1.6), and live birth rates (0.6 versus 24.4) significantly increased in Cycle B. Similar results were obtained in Group B (n=83; 2PN zygotes [1.7 ± 1.7 versus 2.3 ± 1.8], good blastocysts [0.4 ± 0.7 versus 0.9 ± 1.3], live birth rates [0 versus 18.1]) and Group C (n=73; MII oocytes [5.1 ± 3.8 versus 6.6 ± 4.0], 2PN zygotes [4.0 ± 3.4 versus 5.4 ± 3.4], good blastocysts [0.7 ± 1.1 versus 1.6 ± 1.9], and live birth rates [1.4 versus 31.5]).ConclusionThis original protocol increased the number of MII oocytes retrieved, 2PN zygotes, good blastocysts, and live birth rates in both poor responders and in patients with poor-quality embryos.