bluuebunny/crossref_metadata_2025_split huggingface dataset:
Revolutionizing ocular drug delivery: recent advancements in in situ gel technology
Authors: Paul Susanta , Majumdar Subhabrota , Chakraborty Mainak 
Published: October 2023

Abstract
Background
Ophthalmic in situ gel is a novel preparation. It can be instilled into the eye as a liquid but gels upon contact with the ocular surface, generating a sustained-release depot of the drug.

The main body of the abstract
Among drug delivery modalities, ocular drug administration requires careful study and parameter assessment. This is because the eyes are sensitive and require careful care. Conventional ocular administration techniques quickly eliminate formulated compounds, minimizing epithelial interaction. This review covers polymers used in ocular medication delivery, their uses, and their drawbacks. The in situ gelling mechanism converts liquid formulations into gels under certain physiological or environmental conditions. When they contact the ocular surface, in situ ocular gels undergo this transformation for medication administration. Different mechanisms drive this change, depending on the gel's formulation and desired properties. Temperature-, pH-, and ion-induced gelation are common processes of in situ ocular gel formation. The medicine's physicochemical qualities, desired drug release kinetics, ocular environment, and patient comfort determine the mechanism. Researchers can create ocular gels that transport medications, improve bioavailability, and increase patient compliance by carefully formulating and understanding the in situ gelation mechanism. These polymers are useful in prodrug research and ocular penetration enhancement. The article thoroughly discusses polymeric systems and creates a viable ophthalmic drug delivery formulation.

Short conclusion
In conclusion, in situ ocular gels advance ocular medication delivery. These gels overcome various difficulties of current delivery strategies for ocular therapeutics and provide a diverse and effective platform. In situ gelling, where the liquid formulation becomes a gel when it contacts ocular tissues, improves medication retention, bioavailability, and contact time.
Changing fire regimes in East and Southern Africa’s savanna-protected areas: opportunities and challenges for indigenous-led savanna burning emissions abatement schemes
Authors: Croker Abigail R. , Woods Jeremy , Kountouris Yiannis 
Published: October 2023

AbstractBackgroundLate dry-season wildfires in sub-Saharan Africa’s savanna-protected areas are intensifying, increasing carbon emissions, and threatening ecosystem functioning. Addressing these challenges requires active local community engagement and support for wildfire policy. Savanna burning emissions abatement schemes first implemented in Northern Australia have been proposed as a community-based fire management strategy for East and Southern Africa’s protected areas to deliver win–win-win climate, social, and biodiversity benefits. Here, we review and critically examine the literature exploring the design and application of savanna burning emissions abatement schemes in this region, characterizing their contextual and implementation challenges.ResultsWe show that the application of Northern Australian savanna burning methodologies in East and Southern Africa tends to adopt centrally determined objectives and market-based approaches that prioritize carbon revenue generation at the national level. The exclusive prescription of early-dry season burns in African mesic savannas prone to woody thickening can compromise savanna burning objectives to mitigate late-dry season wildfires and their greenhouse gas emissions in the long-term, as well as present multiple biodiversity trade-offs in the absence of formal metrics monitoring species’ responses to changes in fire regime. These features restrict indigenous participation and leadership in fire management, creating uncertainties over the opportunities for local income generation through carbon trading. Findings suggest that future savanna burning applications will need to address asymmetries between formal institutions and local land governance systems, explicitly acknowledging colonial legacies in institutional arrangements across protected areas and hierarchies in agrarian politics that threaten processes of equitable decentralization in natural resource management.ConclusionWe argue that the effective transfer of the Northern Australian fire management model is limited by a lack of long-term ecological and emissions data and political and institutional barriers, and is hindered by the region’s recent colonial history, population growth, and consequences of rapid climatic change. To provide a community-based strategy, savanna burning schemes need to establish context-specific legal frameworks and implement Free, Prior, and Informed Consent to safeguard the roles and responsibilities of indigenous and local people and their distribution of carbon benefits.
Recent progresses of collagen dressings for chronic skin wound healing
Authors: Shi Shuangni , Wang Lili , Song Chen , Yao Linyan , Xiao Jianxi 
Published: October 2023

AbstractThe skin plays a fundamental role in regulating the body’s internal balance and protecting against external traumas. A broad variety of environmental risk factors frequently result in acute skin wounds, whose inappropriate treatments would lead to chronic skin wounds that are difficult to heal. Traditional dressings have been widely used to repair chronic skin wounds, however their drawbacks such as insufficient hemostatic efficacy and non-moist environment have severely limited their clinical applications. As the principal component of skin, collagen has always been a research hotspot in the field of chronic skin wounds due to its advantages of low antigenicity, high biocompatibility and superior bioactivity. Collagen-based dressings have been increasingly developed to heal the chronic wounds during the past decades, arising from their capability in decreasing protein and electrolyte losses in wound exudate, preventing bacterial contamination, permitting less painful dressing changes, and improving the healing quality. This review overviews recent progress of collagen dressings for chronic skin wound healing. Various commonly used wound dressings for wound management have been first introduced. Collagen wound dressings have been categorized as films, sponges, hydrogels, nanofibers, and powders, and their efficacy has been compared. The critical functions of collagen dressings in wound healing, such as stopping bleeding, shortening inflammation, promoting angiogenesis, and stimulating tissue regeneration have been elaborated. The clinical applications of collagen dressings to repair different types of chronic wounds have been thoroughly summarized. A comprehensive list of commercialized collagen dressings has been updated, and an outlook of collagen dressings have been finally speculated.
Graphical Abstract
Clinical, physiological, and radiological different phenotypes of COPD patients
Authors: Galal Islam , Rabie Zeinab , Ahmed Shazly , Mhsb Ahmed Hamdy , Kotb Samah 
Published: October 2023

Abstract
Background
COPD is a heterogeneous lung disorder with multiple phenotypes and endotypes. This study aimed to identify the diverse clinical, physiological, and radiological phenotypes of COPD. Moreover, to provide whether there was a possible relation between FEV1%, FVC%, and FEV1/FVC ratio, [both before and after broncho-dilation with the diameters of the airway at three diverse levels throughout both inspiratory and expiratory phases of respiration].

Results
This study included 50 cases, that were classified according to the radiological phenotypes into 5 groups [29 cases (58%) were mild [centrilobular emphysema) CLE)], 8 cases (16%) were moderate CLE, 5 cases (10%) were [confluent emphysema (CON)], 5 cases (10%) were [advanced destructive emphysema (ADE)] and 3 cases (6%) were [para septal emphysema (PSE)]. There was no considerable variance in the frequency of COPD clinical phenotypes among the diverse radiological phenotypes. There was a moderate positive correlation between the predicted FEV1% and the corresponding inter-luminal diameter at the selected levels (RB1, and LB3) in the inspiratory phase of respiration (P < 0.001 and p = 0.001 respectively) (r = 0.58, 0.46 respectively). and there was a moderate positive correlation in the expiratory phase of respiration between the predicted FEV1% and the equivalent inter-luminal diameter at the selected levels (RB1, and LB3) (P < 0.001 respectively) (r = 0.62, 0.51 respectively).

Conclusions
We confirmed that COPD is a highly heterogeneous illness, with multiple diverse clinical, physiological, and radiological phenotypes. Furthermore, HRCT can well be allied with pulmonary function tests (PFT).
Efficacy and Safety of Trastuzumab Deruxtecan in Patients With HER2-Expressing Solid Tumors: Primary Results From the DESTINY-PanTumor02 Phase II Trial
Authors: Meric-Bernstam Funda , Makker Vicky , Oaknin Ana , Oh Do-Youn , Banerjee Susana , González-Martín Antonio , Jung Kyung Hae , Ługowska Iwona , Manso Luis , Manzano Aránzazu , Melichar Bohuslav , Siena Salvatore , Stroyakovskiy Daniil , Fielding Anitra , Ma Yan , Puvvada Soham , Shire Norah , Lee Jung-Yun 
Published: October 2023

PURPOSE Trastuzumab deruxtecan (T-DXd) is a human epidermal growth factor 2 (HER2)–directed antibody-drug conjugate approved in HER2-expressing breast and gastric cancers and HER2-mutant non–small-cell lung cancer. Treatments are limited for other HER2-expressing solid tumors. METHODS This open-label phase II study evaluated T-DXd (5.4 mg/kg once every 3 weeks) for HER2-expressing (immunohistochemistry [IHC] 3+/2+ by local or central testing) locally advanced or metastatic disease after ≥1 systemic treatment or without alternative treatments. The primary end point was investigator-assessed confirmed objective response rate (ORR). Secondary end points included safety, duration of response, progression-free survival (PFS), and overall survival (OS). RESULTS At primary analysis, 267 patients received treatment across seven tumor cohorts: endometrial, cervical, ovarian, bladder, biliary tract, pancreatic, and other. The median follow-up was 12.75 months. In all patients, the ORR was 37.1% (n = 99; [95% CI, 31.3 to 43.2]), with responses in all cohorts; the median DOR was 11.3 months (95% CI, 9.6 to 17.8); the median PFS was 6.9 months (95% CI, 5.6 to 8.0); and the median OS was 13.4 months (95% CI, 11.9 to 15.5). In patients with central HER2 IHC 3+ expression (n = 75), the ORR was 61.3% (95% CI, 49.4 to 72.4), the median DOR was 22.1 months (95% CI, 9.6 to not reached), the median PFS was 11.9 months (95% CI, 8.2 to 13.0), and the median OS was 21.1 months (95% CI, 15.3 to 29.6). Grade ≥3 drug-related adverse events were observed in 40.8% of patients; 10.5% experienced adjudicated drug-related interstitial lung disease (ILD), with three deaths. CONCLUSION Our study demonstrates durable clinical benefit, meaningful survival outcomes, and safety consistent with the known profile (including ILD) in pretreated patients with HER2-expressing tumors receiving T-DXd. Greatest benefit was observed for the IHC 3+ population. These data support the potential role of T-DXd as a tumor-agnostic therapy for patients with HER2-expressing solid tumors.
Courtesans in Military Uniforms: Martial Spectacles by Cross-Dressing Courtesans of Ŭiju in the Late Chosŏn Period
Authors: Park Hyun Suk 
Published: October 2023

Abstract
This article explores the martial spectacles that the courtesans of Ŭiju, a town on the border of Chosŏn and Qing, offered to envoys and government officials of Chosŏn in the eighteenth and nineteenth centuries. Courtesans were deployed in the border towns by the Chosŏn government in order to provide entertainment honoring the envoys. Their performances, however, do not appear to be strictly aligned with their official obligation to glorify royal authority, as they developed into a repertoire of martial spectacles including a sword dance, horseback riding, a pseudomilitary inspection, and a group hunt. The article examines how the courtesans of Ŭiju cultivated their own performance repertoire by appropriating the heterogeneous resources of the local culture, which were often beyond the grasp of the dominant Confucian values, the hierarchies of gender and social status, and the dehumanizing power of state slavery.
Repeat Cytoreduction and Hyperthermic Intraperitoneal Chemotherapy for Recurrent Mucinous Appendiceal Adenocarcinoma: A Viable Treatment Strategy with Demonstrable Benefit
Authors: Bhutiani Neal , Grotz Travis E. , Concors Seth J. , White Michael G. , Helmink Beth A. , Raghav Kanwal P. , Taggart Melissa W. , Beaty Karen A. , Royal Richard E. , Overman Michael J. , Matamoros Aurelio , Scally Christopher P. , Rafeeq Safia , Mansfield Paul F. , Fournier Keith F. 
Published: October 2023

Abstract
Introduction
Many patients with mucinous appendiceal adenocarcinoma experience peritoneal recurrence despite complete cytoreductive surgery (CRS) and hyperthermic intraperitoneal chemotherapy (HIPEC). Prior work has demonstrated that repeat CRS/HIPEC can prolong survival in select patients. We sought to validate these findings using outcomes from a high-volume center.

Patients and Methods
Patients with mucinous appendiceal adenocarcinoma who underwent CRS/HIPEC at MD Anderson Cancer Center between 2004 and 2021 were stratified by whether they underwent CRS/HIPEC for recurrent disease or as part of initial treatment. Only patients who underwent complete CRS/HIPEC were included. Initial and recurrent groups were compared.

Results
Of 437 CRS/HIPECs performed for mucinous appendiceal adenocarcinoma, 50 (11.4%) were for recurrent disease. Patients who underwent CRS/HIPEC for recurrent disease were more often treated with an oxaliplatin or cisplatin perfusion (35%/44% recurrent vs. 4%/1% initial, p < 0.001), had a longer operative time (median 629 min recurrent vs. 511 min initial, p = 0.002), and had a lower median length of stay (10 days repeat vs. 13 days initial, p < 0.001). Thirty-day complication and 90-day mortality rates did not differ between groups. Both cohorts enjoyed comparable recurrence free survival (p = 0.82). Compared with patients with recurrence treated with systemic chemotherapy alone, this select cohort of patients undergoing repeat CRS/HIPEC enjoyed better overall survival (p < 0.001).

Conclusions
In appropriately selected patients with recurrent appendiceal mucinous adenocarcinoma, CRS/HIPEC can provide survival benefit equivalent to primary CRS/HIPEC and that may be superior to that conferred by systemic therapy alone in select patients. These patients should receive care at a high-volume center in the context of a multidisciplinary team.
Ludowa bajka konkursowa – nowa forma folkloru?
Authors: Wróblewska Violetta 
Published: October 2023

Zasadniczym celem artykułu jest prezentacja ludowej bajki konkursowej oraz próba odpowiedzi na pytanie, czy jest to nowa forma folkloru. Podstawę materiałową rozważań stanowią przekazy/teksty nadsyłane na konkursy ludoznawcze ogłaszane w latach 1955–1966 przez Muzeum Etnograficzne im. Marii Znamierowskiej-Prüfferowej w Toruniu, Polskie Towarzystwo Ludoznawcze – Oddział Toruń oraz Polskie Radio w Bydgoszczy. Z ponad 6 500 nadesłanych tekstów uwzględniono w badaniach jedynie bajki (ponad 350), które w założeniu organizatorów konkursów (łącznie odbyło się sześć) miały stanowić zapis tradycyjnych chłopskich przekazów. Wybrane opowieści, w większości realizacje znanych wątków opisanych w Polskiej bajce ludowej w układzie systematycznym przez Juliana Krzyżanowskiego, poddano analizie, wydobywając z nich cechy zarówno je łączące, jak i odrębne w stosunku do przekazów z przeszłości, aby scharakteryzować nowe zjawisko, z którym mamy do czynienia, czyli ludową bajkę konkursową.
“About God at war”. Forms and features of religious Internet folklore pertaining to the Russo-Ukrainian war
Authors: Koval-Fuchylo Iryna , Orszulak-Dudkowska Katarzyna 
Published: October 2023

The article focuses on the issue of religious online folklore disseminated in connection with the Russian invasion of Ukraine on the popular social media platform Facebook (Ukrainian version), between April and June 2022. The aim of the analysis of the collected material presented in the text is to show the basic forms and functions of religious folklore in the context of the Russo-Ukrainian war, their relationship with other messages of religious content (prayers, appeals and supplications) and the specificity of Internet communication. The authors undertake to show the connections the studied messages exhibit with religious thinking and the Christian tradition on a verbal and visual level, as well as the identity of the Ukrainian people. They also point to the importance of Internet communication in times of helplessness and deep crisis.
Farmers and traders: two ethe of work, two conventions of storytelling in memory-based stories told by the Vilamovians about the Second World War and the post-war persecutions
Authors: Król Tymoteusz 
Published: October 2023

The Vilamovians are an ethnic group living in the town of Wilamowice in the borderland of Silesia and Lesser Poland. Literature has presented them as a homogeneous group whose members were famous for being traders, yet in reality the Wilamowice community was divided into several social strata. Especially the two dominant ones – large farm owners and traders – represented different ethe, which influenced two storytelling conventions, one focused on trade, the other – on agriculture. These conventions are apparent in memory-based stories told by the Vilamovians. In the former, it is work that constitutes the central motif and is valued in itself; in the latter, work is only the means to an end, which is to acquire more wealth. Today, as a result of the fabulisation and folklorisation of the content disseminated in the media, the trade-oriented convention has become dominant. Meanwhile, the work-oriented convention was more popular among the older generation, and is still clearly discernible today in memory-based stories about the Volksliste and the post-war persecution of the inhabitants of Wilamowice. These stories, however, do not tell us how the Vilamovians really behaved, but about what values the narrators professed at the time of conveying the given message. Their form was influenced by the narrative tradition of the given community – be it ethnic or professional.
„Lepiej cały kufel wypić, aniżeli kroplę rozlać”. Spożycie alkoholu w świetle przysłów w językach hiszpańskim i polskim
Authors: Szymański Jakub 
Published: October 2023

W artykule w ujęciu kontrastywnym przeanalizowano kwestie dotyczące spożycia alkoholu poruszane w zbiorach przysłów w dwóch językach (polskim i hiszpańskim w odmianie z Półwyspu Iberyjskiego i wariancie meksykańskim). Obejmują one m.in. przyjemność płynącą z picia alkoholu, aprobatę lub dezaprobatę wobec jego spożycia, stosunek do abstynencji i ludzi niepijących, a także skutki konsumpcji. Korpus stanowiący podstawę badań składa się z ponad 2 900 przysłów z zakresu jedzenia i picia, a część analityczna wykorzystuje metodologię prac kontrastywnych w dziedzinach paremiologii i frazeologii. Celem artykułu jest zbadanie zakorzenionych w kulturze i kulturowo motywowanych sądów i przekonań odzwierciedlonych w przysłowiach, a także zachęcenie do ogólnej refleksji nad wartościami przekazywanymi w paremiach. Wnioski płynące z analizy pozwalają dostrzec szereg podobieństw między językami i kulturami, ale ukazują również istotne różnice w podejściu do konsumpcji alkoholu, a dodatkowo także perspektywę, z jakiej były tworzone.
O potrzebie i początkach turystyki robotniczej na Śląsku Cieszyńskim w świetle programu i działalności Stowarzyszenia Polskich Robotników i Robotnic „Siła” (1908–1939)
Authors: Studnicki Grzegorz 
Published: October 2023

W artykule omówiono popularyzację turystyki i sportu wśród młodzieży robotniczej Śląska Cieszyńskiego w pierwszych dekadach XX w. Analiza treści dotyczących aktywności fizycznej publikowanych w miesięczniku „Oświata” Polskiego Stowarzyszenia Robotniczego Oświatowo-Gimnastycznego „Siła” pozwala zaobserwować, w jaki sposób owa aktywność nabierała politycznego wymiaru, a jej formy, np. sport i turystyka, stawały się narzędziem emancypacji klasy robotniczej.
Help-and-Haggle: Social Commerce Through Randomized, All-or-Nothing Discounts
Authors: Yang Luyi , Jin Chen , Shao Zhen 
Published: October 2023

This paper studies a novel social commerce practice known as “help-and-haggle,” whereby an online consumer can ask friends to help her “haggle” over the price of a product. Each time a friend agrees to help, the price is cut by a random amount, and if the consumer cuts the product price down to zero within a time limit, she will get the product for free; otherwise, the product reverts to the original price. Help-and-haggle enables the firm to promote its product and boost its social reach as consumers effectively refer their friends to the firm. We model the consumer’s dynamic referral behavior in help-and-haggle and provide prescriptive guidance on how the firm should randomize price cuts. Our results are as follows. First, contrary to conventional wisdom, the firm should not always reduce the (realized) price-cut amount if referrals are less costly for the consumer. In fact, the minimum number of successful referrals the consumer must make to have a chance to win the product can be nonmonotone in referral cost. Second, relative to the deterministic price-cut benchmark, a random price-cut scheme improves firm payoff, extracts more consumer surplus, and widens social reach. Additionally, in most instances, it also reduces the promotion expense while increasing profit from product sales at the same time. Third, help-and-haggle can be more cost effective in social reach than a reward-per-referral program that offers a cash reward for each successful referral. However, using the prospect of a free product to attract referrals cannibalizes product sales, potentially causing help-and-haggle to fall short. Yet, if consumers are heterogeneous in product valuations and referral costs or face increasing marginal referral costs, help-and-haggle can outperform the reward-per-referral program. This paper was accepted by Elena Katok, operations management. Funding: L. Yang acknowledges the Berkeley Haas Center for Growth Markets [2022 Grant Award]. C. Jin acknowledges the Singapore Ministry of Education Academic Research Fund [Tier 1 Grant 251RES2101]. Z. Shao acknowledges support from the National Natural Science Foundation of China [Grant 72071188]. All authors acknowledge the Networks, Electronic Commerce and Telecommunications (NET) Institute [2022 Summer Research Grant]. Supplemental Material: The data files and online appendix are available at https://doi.org/10.1287/mnsc.2023.4948 .