bluuebunny/crossref_metadata_2025_split huggingface dataset:
Native collagen VI delays early muscle stem cell differentiation
Authors: Metti Samuele , Da Ros Francesco , Toniato Giorgia , Cescon Matilde , Bonaldo Paolo 
Published: January 2024

ABSTRACT
Adult muscle stem cells (MuSCs) are critical for muscle homeostasis and regeneration, and their behavior relies on a finely regulated niche made of specific extracellular matrix (ECM) components and soluble factors. Among ECM proteins, collagen VI (Col6) influences the mechanical properties of the niche and, in turn, MuSC self-renewal capabilities. Here, we investigated whether Col6 can exert a direct function as a biochemical signal for regulating the stemness and differentiation of murine MuSCs and myoblasts. Native Col6, but not its pepsin-resistant fragment, counteracts the early differentiation of myogenic cells by reducing the expression of differentiation marker genes and preserving stemness features, with inhibition of the canonical Wnt pathway. Our data indicate that extracellular Col6 acts as a soluble ligand in delaying early myogenic differentiation by regulating intracellular signals involved in adult myogenesis.
Membrane trafficking in neurodevelopmental disorders – new insight and therapeutic implications
Authors: Pawłowicz Małgorzata 
Published: January 2024

Introduction: Membrane trafficking processes are essential for cell viability and basic functions, as well as for interactions between the cell interior and the surrounding environment.
Purpose: This article focuses on the review of specific subgroup of inherited neurodevelopmental disorders caused by membrane trafficking dysfunction. The possibility of innovative therapeutic approaches based on selective effects on membrane trafficking processes is also discussed.
State of knowledge: Most previously published reviews are lists of multi-organ diseases related to membrane trafficking dysfunction that are grouped by damaged genes/proteins or by single dominant clinical symptom. No review that focused exclusively on the subgroup of neurodevelopmental diseases related to membrane trafficking defects and their differential diagnosis useful in clinical practice, could be identified.
Conclusions: Neurodevelopmental diseases related to membrane trafficking defects constitute a significant still growing group of rare/ultra-rare disorders which, due to the spectrum of symptoms, require differentiation from the more common neurogenetic syndromes with different pathomechanisms of the disease, but also related to intellectual disability, autism, epilepsy or neurodegenerative processes. The design of innovative drugs based on selective effects on membrane trafficking processes creates wide opportunities for precise, targeted therapeutic intervention, with a significantly minimized risk of its ineffectiveness or side effects.
Impact of soy isoflavones on the prevention and treatment of obesity
Authors: Wąsik Karolina , Tomaszuk Sebastian , Wojtuś Magda 
Published: January 2024

Introduction and purpose:
Currently, as the frequency of obesity is alarming, the role of many factors that could contribute in preventing and treating this condition are being researched, among them the certain food with beneficial health profiles - one of them is soybeans, specifically the isoflavones it contains. Populations that consume soy are known for lower risk of various disorders - among them obesity. The aim of this paper is to summarize the existing paper about the role of these bioactive components in the treatment of this condition. The search was conducted using PubMed and Google Scholarship databases.
Brief description of the state of knowledge:
Obesity is one of the leading challenges in today’s healthcare as it leads to various chronic diseases that are fraught in consequences. Current knowledge is pointing into the association between composition of the soy isoflavones and the lower risk of obesity. Results of the studies indicate that patients affected with obesity could benefit from introducing soy isoflavones into their diet along with other necessary modifications.
Conclusions:
Soy isoflavones are potential agents in the holistic obesity treatment. Consumption of isoflavones merits further recognition as foregoing results of conducted studies are pointing to its possibly meaningful role. It is worth mentioning that consumption of soy isoflavones is not only an anti-obese factor, but also presents various other health benefits and when consumed rationally poses no risk to human’s well being. We conclude that further studies would enable us to fully reveal the potential of those polyphenols.
SENTIDO DO TRABALHO E DEFICIÊNCIA: um estudo com cadeirantes após lesão medular
Authors: Oliveira Carolina Cristina Moreira de , Marra Adriana Ventola , Lara Samara de Menezes 
Published: January 2024

Os indivíduos que adquiriram alguma deficiência física tendem a ser mais propensos à necessidade do trabalho. Nesse contexto, o objetivo geral deste estudo é compreender os sentidos construídos sobre o trabalho para cadeirantes com deficiência adquirida. Foi realizada uma pesquisa qualitativa em que foram entrevistados, em profundidade, sete sujeitos dentro deste perfil. As entrevistas foram transcritas e analisadas por meio da análise de conteúdo. Os sentidos relacionados ao trabalho foram agrupados em: garantia de segurança, independência e autonomia; fonte de satisfação; eficiência e condução de resultados; manutenção da ocupação e sentimento de utilidade; construção de relações sociais positivas; moralmente aceitável e contribuição social; ocupação de espaços e representatividade social; negação do estigma de incapacidade e inclusão efetiva. Concluiu-se que os sentidos do trabalho para os cadeirantes estão ancorados, não apenas no caráter instrumental, mas também nas questões de ocupação de espaços, de utilidade social e de quebra do capacitismo.
Polska, Rosja, Ukraina i Litwa po rozejmie w lasku Compiègne. O książce i redaktorce
Authors: Lityński Adam 
Published: January 2024

Artykuł jest analizą książki O Niepodległą. Kierunek północno-wschodni (1920), wydanej pod redakcją Diany Maksimiuk (Białystok – Warszawa 2022) w ramach realizowanego w latach 1918–1922 projektu „Moja Niepodległa” (na stulecie odzyskania niepodległości). Książka zawiera jedenaście rozpraw i obszerny wstęp przygotowany przez redaktorkę pracy. Przedstawia wydarzenia sprzed ponad stu lat, gdy narody sąsiadujące z Rosją próbowały się wybić na niepodległość.
Biological activities of African medicinal plants in the treatment of erectile dysfunction: a mechanistic perspective
Authors: Babalola Olorunfemi Oyewole , Iwaloye Opeyemi , Ottu Paul Olamide , Aturamu Precious Olayinka , Olawale Femi 
Published: January 2024

Abstract
The global incidence of erectile dysfunction is increasingly becoming a significant health concern, as its frequency demonstrates a consistent upward trajectory each year. In recent years, FDA-approved drugs like sildenafil among others has been approved to treat this disorder however the drug is not without its own side effects. In a bid to develop alternative therapeutic option, scientists have now turned to traditional medicine in search of a treatment regimen. Africa is blessed with numerous medicinal plants used in the treatment and management of several diseases including erectile dysfunction. Due to limited access to modern medicine and high-quality medical facilities, a significant number of individuals in Africa continue to depend on traditional medicine as a means of addressing critical health issues. Perhaps one of the grossly explored medicinal properties of plants in Africa is for erectile function. Through years of extensive research in medicinal plants, several plants indigenous to Africa have been identified to show profound ability to mitigate erectile dysfunction. While previous reports have indeed corroborated the ability of this plant to abate erectile dysfunction, there is still a dearth of information regarding the mechanistic aspect of these plants. Hence, the current review aims to provide a comprehensive mechanistic perspective to the major African medicinal plant which have been reported to be effective in the treatment of erectile dysfunction.
A systematic review of the use of WeChat in teaching Chinese as a foreign language
Authors: Liu Weiming 
Published: January 2024

Abstract
Over the years, social media have gained popularity as tools for language teaching. The social media platform WeChat has been employed for teaching Chinese as a foreign language (TCFL). While studies have investigated the use of WeChat for TCFL, no systematic reviews have been conducted to provide an overview of existing research. This review article examines empirical studies on WeChat in TCFL, summarising their main characteristics, findings, and critically assessing the quality and relevance of the available evidence. Scopus and Web of Science were used as primary databases for this review. Relevant studies were identified by using keyword sets such as “WeChat Chinese language”, “WeChat Mandarin”, “WeChat Hanyu” and “WeChat Putonghua”. The review identified the contexts, research methods and themes of the selected articles. The main themes include language learning, social interactions, learner agency and motivation. The paper also discusses the implications of using WeChat for TCFL and highlights areas for future research. It is hoped that the insights provided here will inform the design and implementation of future courses that use WeChat or other technology-assisted applications for language teaching.
Optimizing Clinical Legal Education for Enhanced Alternative Dispute Resolution: A Collaborative Approach between Law Schools and the Indonesian Arbitration Institution (BANI)
Authors: Herliana Herliana , Mubdi Umar , Sempurno Arief , Syifa Erma Nuzulia 
Published: January 2024

This article aims to integrate ADR teaching directly into CLE method by involving dispute settlement institutions such as Indonesian Arbitration Center/Badan Arbitrase Nasional Indonesia (BANI) and Indonesian National Mediation Center/Pusat Mediasi Nasional (PMN). This is an important step because professions as arbitrator and mediator are extremely needed. Almost every contract incorporates an ADR clause to settle any disputes arising out of the contractual relationship. If CLE in ADR is to succeed in Indonesia, the mindset of the legal community must change. Promoting amicable settlement to disputes can no longer be done in class by traditional teaching method, but instead must involve professionals arbitrator and mediator, fully integrated and supported not only in the law school but also in the community.
The Urgency of Reviewing the Revocation of the Sea Sand Export Ban Policy
Authors: Alfani Tsania Nuha , Rahmawati Putri , Noviyani Nelli 
Published: January 2024

The lifting of the ban on the export of sea sand is a policy that impacts marine ecosystems and coastal communities. Protecting the environment is part of the state's obligation, which is also the right of every citizen. Unwise management of natural resources has a significant impact on environmental balance. In this case, policies regarding natural resource management are in the spotlight in various countries. One of the natural resources currently getting much discussion is resources resulting from marine sedimentation, such as sea sand, which is the main ingredient used in constructing buildings and other infrastructure.. The research methodology used is a normative juridical approach. This research aims to determine what regulations are in government regulations regarding the management of marine sedimentation products and the urgency of studying the promulgated policies. The research results obtained by the author are that the Government Regulation on Management of Marine Sedimentation Results, which revokes the Presidential Decree on Control and Supervision of Sea Sand Cultivation, only focuses on the administrative obligations of business actors in managing marine sedimentation products. The government must review the impact of managing marine sedimentation results on environmental sustainability.
Keywords: Environmental La; Environmental Conservatio; Environmental Damage; Marine Ecosystem Pollution
Linking Transformational Leadership to OCB in Hospitality Industry: the Mediating Influence of Affective Commitment and Work Engagement
Authors: Istiqomah Suryandari , Riani Asri Laksmi 
Published: January 2024

This paper aims to examine the process of forming the Organizational Citizenship Behavior (OCB) of employees in the hotel industry. This study also uses affective commitment and work engagement as mediating variables to clarify the mechanisms for the effect of transformational leadership on OCB. The design of this study is a quantitative study using a survey method through distributing questionnaires to frontline employees in the hospitality industry. 250 questionnaires distributed there were 218 that can be used. By testing using the Structural Equation Model - Partial Least Square (SEM-PLS) method with SMART PLS 3, it was found that transformational leadership has no direct effect on OCB like most other Asian studies. Affective commitment and work engagement show partial mediating effects in the relationship between transformational leadership and OCB in the workplace. This study found that transformational leadership can influence OCB through the mediating effects of affective commitment and job involvement. These results are expected to enrich the psychological mechanisms that can explain the effect of transformational leadership on OCB. Future research is expected to be able to explain a more comprehensive flow of transformational leadership, affective commitment, work engagement, and OCB.
The Role of Innovation as Mediation from the Influences of Knowledge Sharing and Strategic Location towards Competitive Advantage in SMEs Southeast Sulawesi Province
Authors: Hatani La 
Published: January 2024

The current research aims to examine the influence of knowledge sharing (KS) and strategic locations on innovation and competitive advantage (CA) of small and medium sized enterprises (SMEs). The present research aims to analyze and empirically examine the influence of KS and strategic location on CA through the mediating role of innovation. The sample size of this study was 99 managers of SMEs in Southeast Sulawesi Province. The analytical tool used in testing the research hypotheses is SEM-PLS. These findings indicate that KS and strategic locations has a significantly positive influence on innovation. Similarly, strategic locations and innovation significantly positive effect towards CA. However, KS does not have a significant influence on CA. The main findings in this research show that of innovation has a role as mediation in the relationship between KS and strategic locations to improve CA in SMEs. The findings of this research indicate SMEs must be able to take strategic decisions in determining locations and have the ability to share knowledge through innovation to improve CA.
Colaboración entre Universidades y Gobiernos
Authors: Haro Márquez Sandra 
Published: January 2024

El Laboratorio 717 de Participación e Innovación Democrática en Andalucía ilustra de manera eficaz cómo la colaboración entre instituciones académicas y gubernamentales puede promover la participación ciudadana y la innovación en el ámbito de la democracia. La Ley de Participación Ciudadana de Andalucía, promulgada en 2017, fue pionera al establecer un marco normativo que impulsara la implicación activa de los ciudadanos en asuntos públicos, ya sea de manera presencial o a través de plataformas digitales.
El Laboratorio 717, nacido de la colaboración entre la Universidad de Granada y la Junta de Andalucía, representa una iniciativa innovadora para fortalecer la participación ciudadana y fomentar la innovación en la esfera democrática. Este laboratorio se erige como un espacio dedicado a la reflexión, experimentación y debate sobre la participación, capitalizando la experiencia académica y la cooperación interinstitucional para reforzar la implementación de la ley y explorar nuevas posibilidades a futuro. Esta colaboración entre instituciones es un ejemplo destacado de cómo las universidades pueden desempeñar un rol crucial en la promoción de la innovación pública y la participación de la ciudadanía, contribuyendo al fortalecimiento de la democracia y al fomento de un ambiente de innovación democrática a nivel regional y más allá.
Práctica pedagógica del pensamiento crítico desde la psicología cultural
Authors: Escobar Domínguez María Gisela 
Published: January 2024

Si bien el pensamiento crítico es una competencia fundamental en los actuales enfoques educativos, ha sido objeto de definiciones diversas, exigiendo un abordaje desde su epistemología, teorizaciones y praxis en el aula de clases. La investigación se propuso como objetivo analizar nociones sobre el pensamiento crítico y las prácticas pedagógicas en un grupo de docentes latinoamericanos. Se acudió al paradigma cualitativo-crítico a través del método hermenéutico. La selección de participantes se realizó mediante el procedimiento de muestreo por saturación teórica, obteniéndose un grupo de ocho docentes a quienes se aplicaron entrevistas no directivas a profundidad. En el análisis de resultados emergieron 5 categorías: 1.) Nociones sobre pensamiento crítico, en las cuales se evidencia la tendencia a un énfasis cognitivo y racional; 2.) Praxis didáctica, expresando mayor dominio de las asignaturas de contenido lingüístico como adecuadas para promover el pensamiento crítico; 3.) autoevaluación y necesidad de una mayor reflexión y capacitación sobre la praxis docente en el área, 4.) Currículo y políticas educativas, en la cual se exponen incongruencias entre los currículos y la práctica de aula, y 5.) Pensamiento crítico y rendimiento académico, que expone una relación no lineal entre ambos conceptos. Se concluye que es fundamental evitar los determinismos basados en habilidades que expresan el pensamiento crítico y en su lugar promover aproximaciones complejas que permitan incluir experiencias culturales, sociales y éticas también inherentes al proceso.
Early Childhood Education during conflict and change: Learning from the World War 2 experience of Breslau, Germany/Wroclaw, Poland
Authors: Noel Andrea , Kondracka-Szala Marta 
Published: January 2024

This research explores Early Childhood Education (ECE) during an intensely chaotic historical period in one city in Eastern/Central Europe. Breslau, initially a German city, was transferred to Poland and renamed Wroclaw in 1945 after World War 2. Breslau/Wroclaw experienced intense upheaval before, during, and after the war including the almost complete physical devastation of the city and the ensuing massive migration from the expulsion of ethnic Germans and the resettlement of Poles from eastern regions. The impact of war and government policies on the development and continuance of Early Childhood Education as Hitler and National Socialism rose to power, during the months of uncertainty around the end of the war, and on the establishment of a new system of Early Childhood Education in Wroclaw under Soviet domination receive focus in this paper. The results and discussion are applied to contemporary circumstances such as the current crisis in Ukraine, as well as social and political upheaval arising from other emergencies.
Masculinities to Trans-femininities: Evidence through the “Girl” Film
Authors: Ahmadi Anas 
Published: January 2024

This study aims to explore the life journey of a man who wants to become a transfeminist woman through the perspective of masculinity studies. This study uses a qualitative method. The results of this study are as follows. First, Lara as a transfeminist made psychological changes by making herself a graceful figure, changing her love desires by loving men, and having aspirations of becoming a ballerina so that she is like a natural woman. Second, Lara as a transfeminist made physical changes to become a normal woman by wearing earrings and women's clothes, cooking, doing feminizing hormone therapy to grow breasts, and planning to do a sex reassignment surgery to have a vagina. Third, from the aspect of attitude, Lara's family that supports Lara's transformation from male to female has become a controversy. However, in society, Lara, who is a transfeminist, is still controversial and not everyone accepts the presence of transfeminism/LGBT. This can be seen in how society bullies and sexually harasses her. In the end, Lara, who was assigned as a male, actually turned into a female.
The association of circadian rhythms with academic, physical, and cognitive performance: A systematic review
Authors: Sabaoui Ikram , Lotfi Said , Talbi Mohammed 
Published: January 2024

Introduction. Biological cycles exist across diverse time spans. Circadian rhythms are the most thoroughly examined and significantly influence individuals. These rhythms in physiological measures are affected by cyclical variations in human actions and surroundings over a 24-hour duration. Aim. The present research aims to analyse the association of biorhythm factors with performance in students considering research in the field of chronobiology in relation to the educational field. Research methodology and methods. The present systematic review summarises 34 records treating sleep quality, lifestyle, and circadian preferences in their association with the academic, physical, and cognitive performance of students during their daily life; using a PRISMA model. Results. The current review paper has cited numerous studies that confirm the significant impact of sleep and circadian preference on a student’s academic, psychomotor, and cognitive performance. These two factors play a crucial role in the rhythmicity of a student’s life. Scientific novelty. This study introduces a novel interdisciplinary method that applies findings from the study of biological rhythms to education, revealing how these rhythms affect student learning and performance. By merging chronobiology with educational theory, it opens new research paths and enhances our understanding of the relationship between students’ circadian rhythms and their academic, cognitive and physical results, representing a significant progression in how the field of education is linked with chronopsychology. Practical significance. Educational professionals can use the results obtained to gain a deeper insight into how chronobiological factors may affect student performance, thereby enhancing their comprehension of student productivity and potentially identifying more efficient ways to improve it.
OBJETIVOS DO DESENVOLVIMENTO SUSTENTÁVEL NA AMAZÔNIA LEGAL BRASILEIRA
Authors: Rodrigues Waldecy 
Published: January 2024

A Amazônia Legal, rica em biodiversidade única, enfrenta desafios cruciais à luz dos 17 Objetivos do Desenvolvimento Sustentável (ODS). Este dossiê busca minuciosamente explorar a complexidade da região, delineando estratégias para conciliar o desenvolvimento econômico com a preservação ambiental, enfatizando a importância da governança como elemento fundamental para a transição do discurso para a prática.
Alcançar os ODS na Amazônia Legal é um desafio significativo, mas essencial para garantir um futuro onde a biodiversidade amazônica coexista harmoniosamente com o desenvolvimento econômico sustentável. Este dossiê não apenas informa, mas também convoca à ação, destacando a urgência de abordagens integradas para preservar a Amazônia como um patrimônio natural para as futuras gerações.