bluuebunny/crossref_metadata_2025_split huggingface dataset:
Incidence of concurrent systemic injuries with traumatic proptosis and its effect on outcome – 100 dogs
Authors: Whinery Nicole , Allbaugh Rachel A. , Sebbag Lionel , Walton Rebecca 
Published: January 2024

ObjectiveTo evaluate the incidence of concurrent systemic injuries in dogs with traumatic ocular proptosis and their effect on survival to discharge. Additionally, to evaluate for associations between the type of trauma, each presenting vital signs, minimum laboratory database findings including packed cell volume, total solids, plasma glucose and lactate concentrations, and the diagnosis of concurrent systemic injury and survival.DesignRetrospective study between the years 2017 and 2022.SettingOne university teaching hospital and one large, private practice.AnimalsOne hundred dogs presenting to the hospital with a diagnosis of traumatic ocular proptosis.Measurements and main resultsMedical records were retrospectively reviewed; signalment, breed, sex, age, weight, date of presentation, type of trauma sustained, time from trauma to presentation, vitals on presentation, and minimum laboratory database findings including packed cell volume (PCV), total solids (TS), plasma glucose concentration, and plasma lactate concentration were recorded. A modified animal trauma triage (ATT) score was retrospectively calculated. A total of 17 dogs (17%) had concurrent systemic injury. Compared to dogs without systemic injuries, dogs with systemic injuries had a significantly lower body temperature [median 101.1F (38.3C) vs. 101.6F (38.6C); P = 0.008], significantly higher plasma glucose concentrations (125 mg/dL, 6.9 mmol/L vs. 112 mg/dL, 6.2 mmol/L; P = 0.012) and approaching statistical significance, lower PCV values (median 40 vs. 46%; P = 0.051).ConclusionsDogs presenting with traumatic ocular proptosis do present with concurrent systemic, non-ocular injuries; however, these concurrent injuries do not seem to be associated with survival to discharge.
The BAR Score Predicts and Stratifies Outcomes Following Liver Retransplantation: Insights From a Retrospective Cohort Study
Authors: Krendl Felix J. , Fodor Margot , Buch Madita L. , Singh Jessica , Esser Hannah , Cardini Benno , Resch Thomas , Maglione Manuel , Margreiter Christian , Schlosser Lisa , Hell Tobias , Schaefer Benedikt , Zoller Heinz , Tilg Herbert , Schneeberger Stefan , Oberhuber Rupert 
Published: January 2024

Liver retransplantation (reLT) yields poorer outcomes than primary liver transplantation, necessitating careful patient selection to avoid futile reLT. We conducted a retrospective analysis to assess reLT outcomes and identify associated risk factors. All adult patients who underwent a first reLT at the Medical University of Innsbruck from 2000 to 2021 (N = 111) were included. Graft- and patient survival were assessed via Kaplan-Meier plots and log-rank tests. Uni- and multivariate analyses were performed to identify independent predictors of graft loss. Five-year graft- and patient survival rates were 64.9% and 67.6%, respectively. The balance of risk (BAR) score was found to correlate with and be predictive of graft loss and patient death. The BAR score also predicted sepsis (AUC 0.676) and major complications (AUC 0.720). Multivariate Cox regression analysis identified sepsis [HR 5.179 (95% CI 2.575–10.417), p &lt; 0.001] as the most significant independent risk factor for graft loss. At a cutoff of 18 points, the 5 year graft survival rate fell below 50%. The BAR score, a simple and easy to use score available at the time of organ acceptance, predicts and stratifies clinically relevant outcomes following reLT and may aid in clinical decision-making.
Ternary Phenolate-Based Thiosemicarbazone Complexes of Copper(II): Magnetostructural Properties, Spectroscopic Features and Marked Selective Antiproliferative Activity against Cancer Cells
Authors: Al-Salmi Iman K. , Shongwe Musa S. 
Published: January 2024

The new diprotic ligand 3,5-di-tert-butylsalicylaldehyde 4-ethyl-3-thiosemicarbazone, abbreviated H2(3,5-t-Bu2)-sal4eT, exists as the thio-keto tautomer and adopts the E-configuration with respect to the imine double bond, as evidenced by single-crystal X-ray analysis and corroborated by spectroscopic characterisation. Upon treatment with Cu(OAc)2·H2O in the presence of either 2,9-dimethyl-1,10-phenanthroline (2,9-Me2-phen) or 1,10-phenanthroline (phen) as a co-ligand in MeOH, this thiosemicarbazone undergoes conformational transformation (relative donor-atom orientations: syn,anti → syn,syn) concomitantly with tautomerisation and double deprotonation to afford the ternary copper(II) complexes [Cu{(3,5-t-Bu2)-sal4eT}(2,9-Me2-phen)] (1) and [Cu2{3,5-t-Bu2)-sal4eT}2(phen)] (2). Crystallographic elucidation has revealed that complex 1 is a centrosymmetric dimer of mononuclear copper(II) complex molecules brought about by intermolecular H-bonding. The coordination geometry at the copper(II) centre is best described as distorted square pyramidal in accordance with the trigonality index (τ = 0.14). The co-ligand adopts an axial–equatorial coordination mode; hence, there is a disparity between its two Cu–N coordinate bonds arising from weakening of the apical one as a consequence of the tetragonal distortion. The axial X-band ESR spectrum of complex 1 is consistent with retention of this structure in solution. Complex 2 is a centrosymmetric dimer of dinuclear copper(II) complex molecules exhibiting intermolecular H-bonding and π-π-stacking interactions. The two copper(II) centres, which are 4.8067(18) Å apart and bridged by the thio-enolate nitrogen of the quadridentate thiosemicarbazonate ligand, display two different coordination geometries, one distorted square planar (τ4 = 0.082) and the other distorted square pyramidal (τ5 = 0.33). Such dinuclear copper(II) thiosemicarbazone complexes, which are crystallographically characterised, are extremely rare. In vitro, complexes 1 and 2 outperform cisplatin as antiproliferative agents in terms of potency and selectivity towards HeLa and MCF-7 cancer cell lines.
Risk factors for malignant oral mucosal lesion development (literature review). Part 2. Exogenous factors
Authors: Lunitsyna Yu. V. , Lazarev A. F. , Tokmakova S. I. , Bondarenko O. V. 
Published: January 2024

Relevance. Cancer stands as a prominent cause of untimely mortality in young and middle-aged individuals (aged 20-64 years). The inquiry into the extent of influence exerted by external risk factors on the emergence of oral mucosal oncopathology remains pertinent. Equally crucial is understanding the intricate interplay among different groups of factors and their effects.Research objective. To determine the extent of influence exerted by various endogenous and exogenous risk factors on the development of malignant oral mucosal lesions, based on contemporary literature data, and to assess their interrelationships.Materials and methods. The research material was the analysis of literary data from bibliographic sources – Elsevier, PubMed, Elibrary, Google Academy, Medline, Cyberleninka. The study included literature sources in Russian and English. The second part of the review combines studies devoted to the study of the influence of exogenous controlled factors on the risk of developing malignant neoplasms of the oral mucosa.Results. Through contemporary literature analysis, the potential and scale of influence attributed to controllable exogenous risk factors in the development of malignant oral mucosal lesions have been established. Notably, significant impact has been associated with smoking and alcohol consumption. Additionally, adverse socio-economic conditions, environmental factors, and dietary habits have been identified as contributors to an elevated cancer risk. Throughout this investigation, it became evident that literature sources frequently highlight the influence of individual factors without adequately considering potential synergies, antagonistic effects, or interactions with endogenous factors. Moreover, certain factors pivotal to the carcinogenesis of oral cavity tumors remain inadequately researched.Conclusion. To facilitate efficient primary and secondary prevention measures, it is imperative to advance and refine a multidisciplinary research methodology. This approach should aim to comprehensively identify the collective impact of diverse groups of risk factors on the progression of malignant oral mucosal lesions.
Bartolomeo Anglico, «the English Pliny» ?
Authors: Lonati Elisa 
Published: January 2024

Il presente contributo si propone di condurre un’analisi esaustiva delle riprese che il De proprietatibus rerum del francescano Bartolomeo Anglico († dopo il 1245) trasse dalla Naturalis historia di Plinio il Vecchio, soprattutto in ambito zoologico e botanico. Rivelando un ampio numero di passi erroneamente attribuiti a Plinio, l’inchiesta spinge ad interrogarsi sulle ragioni dello scambio con auctoritates
concorrenti, nonché a risalire alle vere fonti di determinate riprese, solo alla lontana dipendenti dalla Naturalis historia. Il confronto sistematico con il testo di quest’ultima offre inoltre l’occasione di identificare un piccolo gruppo di manoscritti pliniani, cui il modello di Bartolomeo presumibilmente apparteneva, e solleva numerose problematiche metodologiche soprattutto in merito a sezioni del De proprietatibus rerum ancora prive di un’edizione critica.
The Potential of Human Mesenchymal Stem Cells in the Treatment of Immune Thrombocytopenia
Authors: Фролова Р.Л. , Исайкина Я.И. , Углова Т.А. , Жерносеченко А.А. , Лях Е.Г. , Новикова М.А. , Савич Ю.В. 
Published: January 2024

Представлен обзор опубликованных фундаментальных исследований роли иммунных механизмов в патогенезе ИТП и иммуномодулирующего действия мезенхимальных стволовых клеток (МСК), а также результаты первых клинических испытаний применения МСК для лечения взрослых пациентов с ИТП. Последние данные подтверждают способность МСК подавлять аутореактивные иммунные процессы, лежащие в основе ИТП, в экспериментах in vitro и in vivo. Клеточная терапия МСК уже показала свою безопасность и эффективность для лечения рефрактерной ИТП в исследованиях с небольшим числом взрослых пациентов, но существует необходимость в проведении проспективных рандомизированных клинических испытаний для подтверждения терапевтического эффекта этого нового метода лечения ИТП как у взрослых, так и у детей.
The latest data confirm the ability of allogeneic mesenchymal stem cells (MSCs) to downregulate autoreactive immune processes underlying the ITP, both in vitro and in vivo experiments. The safety and efficacy of the MSCs transplantation have been demonstrated in studies that included a small number of adult patients with refractory immune thrombocytopenia. In the future, large randomized clinical trials are needed to confirm the efficacy of MSCs application for ITP therapy in adult and children.
Features of c.1934dupG Mutation in ASXL1 Gene in Myelodysplastic Syndrome
Authors: Липилкин П.В. , Кулаева Е.Д. , Арамова О.Ю. , Корниенко И.В. , Рябикина Е.В. , Дегтерева Е.В. , Шатохин Ю.В. 
Published: January 2024

Мутация c.1934dupG в гене ASXL1 при миелодиспластическом синдроме связана с плохим прогнозом и низкой общей 5-летней выживаемостью, а также с высоким риском трансформации в острый миелоидный лейкоз. Большинство исследований этой мутации при миелодиспластическом синдроме проводилось в основном с помощью секвенирования, которое имеет ограниченную ценность в клинической практике из-за сложности рутинного использования. Хотя c.1934dupG является наиболее распространенной мутацией ASXL1 в гематологических опухолях, она мало изучена при миелодиспластическом синдроме с точки зрения ее влияния на тяжесть заболевания. Поэтому мы провели пилотное исследование, в котором рассмотрели субъективные и объективные критерии течения миелодиспластического синдрома в зависимости от мутационного статуса c.1934dupG. Мы использовали модифицированную аллель-специфическую ПЦР и секвенирование по Сэнгеру для исследования мутации в различных вариантах миелодиспластического синдрома. Наше исследование показало, что мутация c.1934dupG встречается чаще у мужчин с миелодиспластическим синдромом, но не влияет на общую выживаемость и другие клинические, биохимические или иммунофенотипические параметры. Мы ставим под сомнение влияние c.1934dupG, как наиболее частой мутации в гене ASXL1, на прогноз миелодиспластического синдрома.
The c.1934dupG mutation in the ASXL1 gene in myelodysplastic syndrome (MDS) is associated with a poor prognosis for overall 5-year survival and a high risk of transformation into acute myeloid leukemia (AML). Most studies of this mutation in MDS have been performed primarily with sequencing, which has a limited value in clinical practice because of the difficulty of routine use. Although c.1934dupG is the most common mutation in ASXL1 in hematologic tumors, it has been poorly studied in MDS in terms of its effect on the severity of the disease. Therefore, we conducted a pilot study that considers subjective and objective criteria for the course of MDS depending on the mutational status of c.1934dupG. We used modified allele-specific PCR and Sanger sequencing to investigate the mutation in different MDS variants. Our study found that the c.1934dupG mutation was associated with male sex, but not with the overall survival, other clinical, biochemical or immunophenotypic parameters. We cast doubt on the influence of C.1934dupG as the most frequent mutation in the ASXL1 gene on the MDS prognosis.
Diffusion-Weighted Magnetic Resonance Imaging for Non-Hodgkin’s Lymphomas. Literature Review and Own Clinical Experience
Authors: Алексеев С.А. , Троян В.Н. , Рукавицын О.А. , Троян Э.Р. 
Published: January 2024

Данный литературный обзор посвящен анализу возможностей применения одного из современных доступных методов лучевой диагностики у пациентов с неходжкинскими лимфомами для оценки лечения и выявления рецидива заболевания. Это метод диффузионно-взвешенной магнитно-резонансной томографии всего тела (ДВ МРТ), который набирает популярность и является возможной альтернативой использующимся традиционным методам, таким как КТ и ПЭТ/КТ с 18F-ФДГ. В обзоре обсуждаются не только преимущества метода, но также недостатки и подводные камни, с которыми приходится сталкиваться врачу-диагносту.
This literature review is devoted to analyzing the possibilities of using one of the modern available methods of radiodiagnosis in patients with non-Hodgkin lymphoma to evaluate treatment and detect relapse of the disease. This is a whole-body diffusion-weighted magnetic resonance imaging (DWMRI) technique that is gaining popularity and is a possible alternative to current conventional techniques such as CT and 18F-FDG PET/CT. The review discusses not only the advantages of the method, but also the disadvantages and pitfalls that the diagnostician has to face.
Management of a Patient with Primary Mediastinal Large B-Cell Lymphoma Associated with Coronavirus Infection Caused by SARS-CoV-2: Own Clinical Case
Authors: Поляков Ю.Ю. , Барях Е.А. , Мисюрина Е.Н. , Желнова Е.И. , Мингалимов М.А. , Толстых Т.Н. , Чуднова Т.С. , Кочнева О.Л. , Иванова Д.Д. , Зотина Е.Н. , Гаглоева Д.Э. , Паршин В.В. , Лысенко М.А. 
Published: January 2024

Коронавирусная инфекция (COVID-19) – это острое респираторное заболевание, вызванное вирусом SARS-CoV-2, впервые было отмечено в городе Ухань (Китай) и быстро распространилось по всему миру. В условиях пандемии COVID-19 проведение специфического противоопухолевого лечения у пациентов с агрессивными В-клеточными лимфомами стало одной из сложных задач. Проведение специфической противоопухолевой терапии пациентов с гемобластозами, в том числе с агрессивными лимфопролиферативными заболеваниями, требует безотлагательного начала. Отсрочка специфической терапии может привести к прогрессированию лимфомы. Выбирая протокол химиотерапевтического режима, необходимо учитывать риск реактивации COVID-19 на фоне миелотоксической аплазии костномозгового кроветворения, а также дополнительного присоединения бактериальной и грибковой инфекции. Подтвержденная коронавирусная инфекция не должна быть противопоказанием к химиотерапии. В данной публикации представлены собственное клиническое наблюдение течения COVID-19 у пациента с первичной медиастинальной В-клеточной лимфомой на этапе химиотерапевтического лечения, а также выбор режима противоопухолевой терапии.
Coronavirus disease (COVID-19) is an acute respiratory disease caused by the SARS-CoV-2 virus, was discovered first in Wuhan (China) and quickly spread throughout the world. Specific antitumor treatment in patients with aggressive B-cell lymphomas has become one of the most challenging issues in the context of the COVID-19 pandemic. An immediate start of specific antitumor therapy for patients with hematological malignancies including aggressive lymphoproliferative diseases (LPD) is required. The delay of specific therapy may lead to progression of lymphoma. It is necessary to consider the risk of reactivation of COVID-19 due to myelotoxic aplasia of bone marrow hematopoiesis, as well as further development of bacterial and fungal infections when choosing a chemotherapy regimen protocol. Confirmed COVID-19 infection should not be a contraindication for chemotherapy. This publication presents our own clinical experience of COVID-19 infection case in a patient with primary mediastinal B-cell lymphoma at chemotherapy treatment stage, as well as the choice of tactics for the antitumor therapy regimen.
Pengaruh Keragaman Gender Dewan Direksi Terhadap Kinerja Perusahaan yang Terdaftar Di BEI
Authors: Natalia Felisha , Chandra Budi , Ivone  
Published: January 2024

Penelitian ini bertujuan untuk mengetahui pengaruh keragaman gender dewan terhadap kinerja perusahaan finansial yakni perbankan & asuransi yang terdaftar di Indonesia pada periode antara 2017-2021. Variabel Dependen adalah ROA (Return on Assets), sedangkan variabel independen Female Director Blau Index, Umur, Foreign Women Directors, dan Masa Jabatan dengan variabel moderasi yaitu Accounting Expertise. Sampel penelitian Perusahaan yang terdaftar di Bursa Efek Indonesia, dipilih dengan metode purposive sampling, diperoleh 60 perusahaan yang memenuhi kriteria selama 5 tahun. Analisis untuk menguji pengaruh masing-masing variabel independen terhadap dependen adalah dengan menggunakan Regresi Data Panel. Fixed Effect Model merupakan model regresi terbaik dalam penelitian ini. Hasil penelitian mencerminkan bahwa Female Director Blau Index memiliki pengaruh signifikan positif terhadap ROA (Return on Assets). Sementara itu, Umur, Foreign Women Directors, dan Masa Jabatan tidak memengaruhi ROA (Return on Assets).
Hubungan Dukungan Ayah ASI Terhadap Pemberian ASI Eksklusif
Authors: Fatimah  , Roza Adila Dian , Niriyah Sekani 
Published: January 2024

Father's support for breastfeeding is one of the factors that influence a mother to breastfeed exclusively. This study aims to find out the relationship between father's support and exclusive breastfeeding. This type of research is quantitative using a descriptive correlational design and a cross-sectional approach. The sample for this study consists of 50 respondents who are mothers with babies aged 0-6 months who are registered at the Langsat Health Center. Sampling uses random sampling techniques. Data collection using questionnaires. Analysis in this study uses bivariate with the Chi-Square test. The result of the study on the characteristics of respondents aged 26-35 years is a total of 29 respondents (58%), the average number of respondents who are multiparous is 33 respondents (66%), the average ethnicity of the mother is Malay is 26 people. respondents (52%), the average mother's education, i.e. secondary education, was obtained by 34 respondents (68%), the average mother's occupation, i.e. not working, was obtained by 35 respondents (70%), while the father's education, i.e. secondary education, was obtained by 35 respondents (70%) and the average occupation of the father is self-employment. There are 21 respondents (42%). The results of the study showed that exclusive breastfeeding was obtained by 37 respondents (74%), and good breastfeeding father support was obtained by 25 respondents (50%). Bivariate analysis using the Chi-Square test showed a P value of 0.107 (P>0.05), meaning that there is no relationship between breastfeeding father support and exclusive breastfeeding. The community health center is expected to educate the community about the importance of the family's role in the influence of exclusive breastfeeding.
Keyword : Exclusive Breastfeeding, Breastfeeding Father
HUBUNGAN PENGETAHUAN DAN SIKAP PERINEAL HYGINE DALAM PENCEGAHAN KEPUTIHAN REMAJA
Authors: Ayu Wulandari Mike , Wisanti Eka , Roza Adila Dian 
Published: January 2024

Kesehatan reproduksi wanita telah menjadi masalah kesehatan yang harus diperhatikan terutama pada usia remaja. Berbagai masalahkesehatan reproduksi dapat terjadi pada masa remaja, salah satunya karena kurangnya perhatian dan pengetahuan terkait kesehatan reproduksi. Masalah organ reproduksi pada remaja sering terjadi di negara berkembang seperti Indonesia. Tujuan dalam penelitian ini untuk melihat hungungan antara pengetahuan dan sikap perineal hygine terhadap pencegahan keputihan pada remaja. Penelitian ini menggunakan jenis penelitian kuantitatif dengan desain korelasi pendekatan cross-sectional. Populasi pada penelitian ini sebanyak 88 orang.Sampel dalam penelitian ini diambil dengan teknik total sampling sebanyak 88 responden. Penelitian ini dilaksanakan di pondok Pesantren pekanbaru, Penelitian ini menggunakan analisa univariat dan bivariat dengan uji chi square, pada hasil penelitian ini Mayorita usia pada responden 13 Tahun 36 orang (40.9%), Usia remaja pertama kali menstruasi pada usia 11 tahun (47%) dan 12 tahun (26%). pengetahun pada remaja tentang perineal hygine buruk sebanyak 79 siswa (89.8%) dan Jumlah remaja memiliki sikap yang buruk terhadap perineal hygine sebanyak 80 remaja ( 90.9%). penelitian ini didapatkan bahwa terdapat hubungan antara pengetahuan dengan pencegahan keputihan pada remaja di pondok pesantren modern diniyah putri dengan nilai p=.006 (<0.05) dan ada hubungan antara sikap dengan pencegahan keputihan pada remaja di pondok pesantren modern diniyah putri dengan nilai p=.011 (<0.05). Peneliti ini merekomendasikan pihak pesantren memberikan promosi kesehatan tentang perineal hygine.