bluuebunny/crossref_metadata_2025_split huggingface dataset:
Emerging Smart Micro/Nanofiber‐Based Materials for Next‐Generation Wound Dressings
Authors: Dong Yuping , Fu Shaoju , Yu Jianyong , Li Xiaoran , Ding Bin 
Published: November 2023

AbstractSmart wound dressings capable of detecting, monitoring, and regulating complicated dynamic healing processes hold tremendous potential in wound healing and tissue reconstruction. Micro/nanofiber‐based materials are regarded as one of the most promising candidates to develop smart wound dressings owing to their remarkable features including architectural mimicry of extracellular matrix, tunability in structural assembly, and diversity in functionality. Herein, the latest progress of smart micro/nanoscale fiber‐based materials in terms of composition engineering, structural design, and applications in wound management is comprehensively reviewed. This work begins with the advances in smart fibers including stimuli‐responsive fibers, shape memory fibers, and conductive fibers. Then, the structural design of fiber‐based materials from conventional 2D fibrous membrane to emerging 3D fibrous sponge/hydrogel is thoroughly discussed. Furthermore, the applications of smart micro/nanofibrous materials as wound dressings in stimuli‐responsive drug delivery, biomechanical stimulation, electrical stimulation, and wound monitoring are highlighted. Finally, the article offers perspectives on the existing challenges and future directions of smart fibrous materials for wound management.
Ferromagnetic L12‐Pt3Co Nanowires with Spin‐Polarized Orbitals for Fast and Selective Oxygen Reduction Electrocatalysis
Authors: Su Yikun , Wang Zhaoyang , Gao Ruoxi , Wu Qifan , Zhao Jinlai , Zhu Guangming , Li Qiliang , Xu Hongbin , Pan Yiye , Gu Kunming , Biz Chiara , Fianchini Mauro , Gracia Jose 
Published: November 2023

AbstractMagnetic alloys are key to develop efficient catalysts for oxygen reduction reaction (ORR) in fuel cells. During the last decade, it has been shown that spin manipulation of magnetic materials can improve the kinetics of triplet state 3O2 electrocatalysis, promoting the unification between the physics of strongly correlated materials and heterogeneous catalysis. In this study, structurally ordered Pt3Co nanowires (NWs) are synthesized, and their ORR catalytic performances are studied in detail. These intermetallic ordered L12‐Pt3Co NWs exhibit stronger ferromagnetism, superior ORR catalytic activity, and higher tolerance to carbon monoxide than related disordered A1‐Pt3Co NWs, and commercial Pt/C catalyst. These characteristics make them one of (if not) the best catalyst reported nowadays. Density functional theory calculations prove that the L12‐Pt3Co(111) surface displays a lower activation barrier at the ORR rate‐limiting step and better selectivity H2O2/H2O (i.e., lower production of H2O2) compared with disordered A1‐Pt3Co(111). ORR reactivity increases with the level of Co order in the slab. Moreover, L12‐Pt3Co(111) displays more favorable thermodynamics, decreasing the adsorption enthalpies of 3O2, and lower ORR rate‐limiting step, due to ferromagnetic quantum spin exchange interactions (QSEI), compared with Pt(111).
Fiber‐Integrated Force Sensor using 3D Printed Spring‐Composed Fabry‐Perot Cavities with a High Precision Down to Tens of Piconewton
Authors: Shang Xinggang , Wang Ning , Cao Simin , Chen Hehao , Fan Dixia , Zhou Nanjia , Qiu Min 
Published: November 2023

AbstractDeveloping microscale sensors capable of force measurements down to the scale of piconewtons is of fundamental importance for a wide range of applications. To date, advanced instrumentations such as atomic force microscopes and other specifically developed micro/nano‐electromechanical systems face challenges such as high cost, complex detection systems and poor electromagnetic compatibility. Here, it presents the unprecedented design and 3D printing of general fiber‐integrated force sensors using spring‐composed Fabry‐Perot cavities. It calibrates these microscale devices employing varied‐diameter m‐scale silica particles as standard weights. The force sensitivity and resolution reach values of (0.436 ± 0.007) nmnN‐1 and (40.0 ± 0.7) pN, respectively, which are the best resolutions among all fiber‐based nanomechanical probes so far. It also measured the non‐linear airflow force distributions produced from a nozzle with an orifice of 2 m, which matches well with the full‐sized simulations. With further customization of their geometries and materials, it anticipates the easy‐to‐use force probe can well extend to many other applications such as air/fluidic turbulences sensing, micro‐manipulations, and biological sensing.
A Cardiac‐Targeted Nanozyme Interrupts the Inflammation‐Free Radical Cycle in Myocardial Infarction
Authors: Liu Xueliang , Chen Binghua , Chen Jingqi , Wang Xuan , Dai Xinfeng , Li Yuqing , Zhou Huayuan , Wu Lian‐Ming , Liu Zhuang , Yang Yu 
Published: November 2023

AbstractSevere systemic inflammation following myocardial infarction (MI) is a major cause of patient mortality. MI‐induced inflammation can trigger the production of free radicals, which in turn ultimately leads to increased inflammation in cardiac lesions (i.e., inflammation‐free radicals cycle), resulting in heart failure and patient death. However, currently available anti‐inflammatory drugs have limited efficacy due to their weak anti‐inflammatory effect and poor accumulation at the cardiac site. Herein, a novel Fe‐Cur@TA nanozyme is developed for targeted therapy of MI, which is generated by coordinating Fe3+ and anti‐inflammatory drug curcumin (Cur) with further modification of tannic acid (TA). Such Fe‐Cur@TA nanozyme exhibits excellent free radicals scavenging and anti‐inflammatory properties by reducing immune cell infiltration, promoting macrophage polarization toward the M2‐like phenotype, suppressing inflammatory cytokine secretion, and blocking the inflammatory free radicals cycle. Furthermore, due to the high affinity of TA for cardiac tissue, Fe‐Cur@TA shows an almost tenfold greater in cardiac retention and uptake than Fe‐Cur. In mouse and preclinical beagle dog MI models, Fe‐Cur@TA nanozyme preserves cardiac function and reduces scar size, suggesting promising potential for clinical translation in cardiovascular disease.
Lipid Droplet Targeting Type I Photosensitizer for Ferroptosis via Lipid Peroxidation Accumulation
Authors: Xiong Tao , Chen Yingchao , Peng Qiang , Lu Shuai , Long Saran , Li Mingle , Wang Heng , Lu Sheng , Chen Xiaoqiang , Fan Jiangli , Wang Lei , Peng Xiaojun 
Published: November 2023

AbstractAs an iron‐dependent lipid peroxidation (LPO) mediated cell death pathway, ferroptosis offers promises for anti‐tumor treatment. Photodynamic therapy (PDT) is an ideal way to generate reactive oxygen species (ROS) for LPO. However, the conventional PDT normally functions on subcellular organelles, such as endoplasmic reticulum, mitochondria, and lysosome, causing rapid cell death before triggering ferroptosis. Herein, the first lipid droplet (Ld)‐targeting type I photosensitizer (PS) with enhanced superoxide anion (O2−·) production, termed MNBS, is reported. The newly designed PS selectively localizes at Ld in cells, and causes cellular LPO accumulation by generating sufficient O2−· upon irradiation, and subsequently induces ferroptosis mediated chronical PDT, achieving high‐efficient anti‐tumor PDT in hypoxia and normoxia. Theoretical calculations and comprehensive characterizations indicate that the Ld targeting property and enhanced O2−· generation of MNBS originate from the elevated H‐aggregation tendency owing to dispersed molecular electrostatic distribution. Further in vivo studies using MNBS‐encapsulated liposomes demonstrate the excellent anti‐cancer efficacy as well as anti‐metastatic activity. This study offers a paradigm of H‐aggregation reinforced type I PS to achieve ferroptosis‐mediated PDT.
Flexible Conformal Multifunctional Time‐Varying Phase‐Modulated Metasurface with Polarization Control for Radar Feature Transformation
Authors: Sun Guang , Xing Shiqi , Wang Junjie , Feng Dejun , Wang Xuesong 
Published: November 2023

AbstractReconfigurable metasurfaces have shown unprecedented capabilities in controlling electromagnetic (EM) waves in recent years and play an essential role in information manipulation. However, most research on reconfigurable metasurfaces is limited to planar rigid structures, with only one control function and suitable for specific single polarization. Achieving simultaneous control of phase, polarization, and frequency in the conformal structure has significant practical implications in many applications, but remains obviously challenging. In this paper, a flexible multifunctional time‐varying phase‐modulated metasurface (MTPM) with orthogonal polarization control is proposed for conformal applications to manipulate the spectrum distribution. It enables time encoding capability in controlling the phase characteristics of x‐ and y‐polarized EM waves individually by switching the bias voltage of the PIN diode in two directions. Discrete harmonic spectrum and continuous Doppler frequency shifts are implemented separately on two orthogonal polarizations by applying different time coding sequences. As a practical application, a conformal MTPM for radar feature transformation is explored. Multiple discrete false targets and defocusing phenomena can be realized respectively for x‐ and y‐polarized waves. Both simulated and measured results verify the validity of the proposed method and prototype.
Anion Effect on Charged AIEgens‐Based Aggregates
Authors: Liu Qiong , Chen Kongqi , Deng Qiyun , Li Jianqing , Wang Zhiming , Tang Ben Zhong 
Published: November 2023

AbstractCharged aggregation‐induced emission luminogens (AIEgens) are highly valued materials with attractive applications. However, the discussion of charged AIEgens with the characteristics of charged compounds is always centered around the cationic luminescence part, and the possible influence brought by anion effects is usually ignored especially in the field of aggregate science. Coupled with the complicated synthesis and purification processes of the brand‐new cationic nucleus, it is paramount to develop simpler and more feasible methods to enhance cognition and extend their performance. Herein, three new ionic compounds based on TPE‐IQ‐2TPA (TI2T) cationic core utilizing an anion substitution strategy are investigated. Interestingly, this strategy can modify molecular aggregation behavior regarding the photophysical process and arrangement of the molecules. Consequently, fluorescence emission, reactive oxygen species (ROS) generation ability, and mechanochromism response properties varied accordingly. Moreover, this strategic regulation of the physical parameters of self‐assembled nanoparticles facilitates the visual identification of living or dead cells, while also selectively illuminating S. aureus and C. albicans. This study demonstrates that anion engineering is a powerful tool for investigating aggregated states and provides a new platform for practical applications of advanced materials, especially in the fields of stimulus‐response, biological imaging, medical diagnosis, and treatment.
A Multifunctional Hydrogen Bond Bridge Interface to Achieving Efficient and Stable Perovskite Solar Cells
Authors: Zha Leying , Ning Lei , Sun Zeyuan , Song Lixin , Du Pingfan , Xiong Jie 
Published: November 2023

AbstractIn perovskite solar cells (PSCs), the buried interface between the electron transfer layer (ETL) and perovskite (PVK) layer profoundly affects the charge carrier transfer efficiency, which has significant implications for the efficiency and long‐term stability of the device. Herein, an organic chemical compound 4,6‐diamino‐2‐mercaptosine (DMP) is incorporated into the ETL/PVK interface in order to optimize the interfacial performance through a hydrogen bond bridging junction. DMP is tightly anchored to the ETL surface by forming the intermolecular hydrogen bonding with the structure as N─H∙∙∙N. This bridge connection is beneficial for enhancing the interface contact, further restraining severe nonradiative charge recombination. Synchronously, the interaction of ─SH with uncoordinated Pb2+ passivates the defects on the bottom layer of perovskite, further regulating the perovskite crystal growth. Overall, the results express that the power conversion efficiency (PCE) of PSCs based on the DMP interface has significantly increased to 21.65% without obvious hysteresis. Meanwhile, the unencapsulated modified devices show superior environmental stability, maintaining over 85% of their initial PCE even after 500 h in an atmospheric environment.
Mechanistic Insight into Palladium‐Catalyzed Asymmetric Alkylation of Indoles with Diazoesters Employing Bipyridine‐N,N’‐dioxides as Chiral Controllers
Authors: Fukazawa Yasuaki , Vaganov Vladimir Yu. , Burykina Julia V. , Fakhrutdinov Artem N. , Safiullin Ruslan I. , Plasser Felix , Rubtsov Aleksandr E. , Ananikov Valentine P. , Malkov Andrei V. 
Published: November 2023

AbstractMetal‐catalyzed asymmetric alkylation of indoles with α‐diazoesters is well‐known, however, the underlying mechanisms of this reaction, particularly the origin of stereoselectivity, remain uncertain. For the Pd catalysis, we address this cutting‐edge challenge from two complementary viewpoints – i) the molecular level regarding a single catalytically active Pd center; and ii) nano‐level Pd species investigating the factors favoring the appearance of the preferred catalytic centers. The formation of the active catalytic species was monitored by structural methods (NMR and ESI‐MS), and metal particles were characterized with electron microscopy (SEM, EDX). On the molecular level, chiral bipyridine‐N,N’‐dioxides proved to be competent chiral controllers. The kinetic and DFT computational data revealed a crucial role of water in the rate and selectivity determining steps and showed that the enantioselectivity of the process is controlled by the protodepalladation step. On the nano‐scale, the important effect of catalyst precursor on the overall reaction performance was shown.
Synthesis of Phenethylamine‐Azulene Conjugates Enabled by Regioselective Ring Opening of Aziridines
Authors: García‐Martínez Patricia , Bernardo Olaya , Borge Javier , González Javier , López Luis A. 
Published: November 2023

AbstractThe BF3⋅OEt2‐catalyzed reaction of azulene with N‐protected aziridines represents a general, efficient (up to 91% yield) and regioselective approach to phenethylamine‐azulene conjugates. Stereochemical studies and DFT calculations lend support to a concerted SN2‐type mechanism governing the ring‐opening of the aziridine.
Organocatalytic Enantioselective Syntheses of Flavonoids and Cannabinoids
Authors: Vidal‐Albalat Andreu , Matos Paz Bruno 
Published: November 2023

AbstractFlavonoids and cannabinoids comprise two large families of natural products that contain a chromane moiety in their structure. Their therapeutic potential has been extensively investigated as potential treatments to several diseases, ranging from cancer to infectious and neurodegenerative diseases. Despite their relative structural simplicity, in recent years creative synthetic methodologies were designed to overcome limitations from the previous synthetic strategies applied to these compounds. The aim of this review is to provide a comprehensive overview of all the enantioselective organocatalytic strategies that have been applied to the synthesis of flavonoids and cannabinoids to date.
Cell Death Pathway Regulation by Functional Nanomedicines for Robust Antitumor Immunity
Authors: Li Yongjuan , Guo Yichen , Zhang Kaixin , Zhu Rongrong , Chen Xiaoyuan , Zhang Zhenzhong , Yang Weijing 
Published: November 2023

AbstractCancer immunotherapy has become a mainstream cancer treatment over traditional therapeutic modes. Cancer cells can undergo programmed cell death including ferroptosis, pyroptosis, autophagy, necroptosis, apoptosis and cuproptosis which are find to have intrinsic relationships with host antitumor immune response. However, direct use of cell death inducers or regulators may bring about severe side effects that can also be rapidly excreted and degraded with low therapeutic efficacy. Nanomaterials are able to carry them for long circulation time, high tumor accumulation and controlled release to achieve satisfactory therapeutic effect. Nowadays, a large number of studies have focused on nanomedicines‐based strategies through modulating cell death modalities to potentiate antitumor immunity. Herein, immune cell types and their function are first summarized, and state‐of‐the‐art research progresses in nanomedicines mediated cell death pathways (e.g., ferroptosis, pyroptosis, autophagy, necroptosis, apoptosis and cuproptosis) with immune response provocation are highlighted. Subsequently, the conclusion and outlook of potential research focus are discussed.
Near‐Infrared Light‐Driven MXene/Liquid Crystal Elastomer Bimorph Membranes for Closed‐Loop Controlled Self‐Sensing Bionic Robots
Authors: Yang Youwei , Meng Lingxian , Zhang Juzhong , Gao Yadong , Hao Zijuan , Liu Yang , Niu Mingjun , Zhang Xiaomeng , Liu Xuying , Liu Shuiren 
Published: November 2023

AbstractMore recently, soft actuators have evoked great interest in the next generation of soft robots. Despite significant progress, the majority of current soft actuators suffer from the lack of real‐time sensory feedback and self‐control functions, prohibiting their effective sensing and multitasking functions. Therefore, in this work, a near‐infrared‐driven bimorph membrane, with self‐sensing and feedback loop control functions, is produced by layer by layer (LBL) assembling MXene/PDDA (PM) onto liquid crystal elastomer (LCE) film. The versatile integration strategy successfully prevents the separation issues that arise from moduli mismatch between the sensing and the actuating layers, ultimately resulting in a stable and tightly bonded interface adhesion. As a result, the resultant membrane exhibited excellent mechanical toughness (tensile strengths equal to 16.3 MPa (||)), strong actuation properties (actuation stress equal to 1.56 MPa), and stable self‐sensing (gauge factor equal to 4.72) capabilities. When applying the near‐infrared (NIR) laser control, the system can perform grasping, traction, and crawling movements. Furthermore, the wing actuation and the closed‐loop controlled motion are demonstrated in combination with the insect microcontroller unit (MCU) models. The remote precision control and the self‐sensing capabilities of the soft actuator pave a way for complex and precise task modulation in the future.
Numerical study on influence of particle shape and deformation on friction behavior of flexible cylindrical particle flows
Authors: Zhu Yanping , Zhang Hao , Guo Pengyue , An Xizhong , Jiang Shengqiang 
Published: November 2023

AbstractA discrete element method (DEM) model for deformable particles is established and adopted to investigate the Jenike shear process of flexible cylindrical particles with different aspect ratios (4 <  < 6). The DEM model is firstly validated against both experimental data and analytic solutions. Then, numerical simulations are carried out and the effects of particles shape and deformation on their friction behavior are investigated through a particle‐scale analysis on particle deformation, coordinate number, contact forces, orientation and internal friction angle. Comparative results between flexible and rigid particles under the same conditions show that the shear stress increases almost linearly with the normal load regardless of particle stiffness or shape. For both rigid and flexible particles, the shear stress and internal friction angle increase with . The shear stress and internal friction angle of the flexible particles are higher than those of the rigid ones especially when  = 6. The latter has more inter‐particle contacts but the former has stronger contact forces. When  = 4 and 5, the flexible particles without many initial deformations will deform significantly during the shear process with a complex reconfiguration taking place. However, when  = 6, the initial deformation and internal forces of the flexible particles only change slightly during the shear process. It is thus believed that the high shear stress and internal friction angle of the flexible particles with  = 6 are caused by their solid packing structure which strongly enhances the capability of the particle flow to resist shear. The current knowledge will be helpful for improving the kinetic theories for granular flow for complex irregular particle flows.
Montmorillonite K‐10 Clay Promoted Direct Dehydrative Nucleophilic Substitution of Pyrrole and Indole with 4‐Chromanols
Authors: Begum Ayisha F. , Balasubramanian Kalpattu K. , Shanmugasundaram Bhagavathy 
Published: November 2023

AbstractA mild and inexpensive method of alkylation of pyrrole and indole with substituted 4chromanols and 3‐arylidene‐4‐chromanols mediated by montmorillonite K‐10 is reported. Indole and pyrrole upon treatment with 4‐chromanols in the presence of activated montmorillonite K‐10 undergo facile nucleophilic substitution under ambient condition to afford 2‐(chroman‐4‐yl)‐1H‐pyrrole and 3‐(chroman‐4‐yl)‐1H‐indole in moderate to good yields. In the case of 3‐arylidene‐4‐chromanols, this direct dehydrative substitution reaction is found to be highly regioselective affording only the respective C‐4 substituted (arylidene‐chroman‐4‐yl)‐ pyrrole/indole derivatives.
Biological variation estimates of Alzheimer's disease plasma biomarkers in healthy individuals
Authors: Brum Wagner S. , Ashton Nicholas J. , Simrén Joel , di Molfetta Guiglielmo , Karikari Thomas K. , Benedet Andrea L. , Zimmer Eduardo R. , Lantero‐Rodriguez Juan , Montoliu‐Gaya Laia , Jeromin Andreas , Aarsand Aasne K. , Bartlett William A. , Calle Pilar Fernández , Coşkun Abdurrahman , Díaz–Garzón Jorge , Jonker Niels , Zetterberg Henrik , Sandberg Sverre , Carobene Anna , Blennow Kaj 
Published: November 2023

AbstractINTRODUCTIONBlood biomarkers have proven useful in Alzheimer's disease (AD) research. However, little is known about their biological variation (BV), which improves the interpretation of individual‐level data.METHODSWe measured plasma amyloid beta (Aβ42, Aβ40), phosphorylated tau (p‐tau181, p‐tau217, p‐tau231), glial fibrillary acidic protein (GFAP), and neurofilament light chain (NfL) in plasma samples collected weekly over 10 weeks from 20 participants aged 40 to 60 years from the European Biological Variation Study. We estimated within‐ (CVI) and between‐subject (CVG) BV, analytical variation, and reference change values (RCV).RESULTSBiomarkers presented considerable variability in CVI and CVG. Aβ42/Aβ40 had the lowest CVI (≈ 3%) and p‐tau181 the highest (≈ 16%), while others ranged from 6% to 10%. Most RCVs ranged from 20% to 30% (decrease) and 25% to 40% (increase).DISCUSSIONBV estimates for AD plasma biomarkers can potentially refine their clinical and research interpretation. RCVs might be useful for detecting significant changes between serial measurements when monitoring early disease progression or interventions.Highlights
Plasma amyloid beta (Aβ42/Aβ40) presents the lowest between‐ and within‐subject biological variation, but also changes the least in Alzheimer's disease (AD) patients versus controls.
Plasma phosphorylated tau variants significantly vary in their within‐subject biological variation, but their substantial fold‐changes in AD likely limits the impact of their variability.
Plasma neurofilament light chain and glial fibrillary acidic protein demonstrate high between‐subject variation, the impact of which will depend on clinical context.
Reference change values can potentially be useful in monitoring early disease progression and the safety/efficacy of interventions on an individual level.
Serial sampling revealed that unexpectedly high values in heathy individuals can be observed, which urges caution when interpreting AD plasma biomarkers based on a single test result.