bluuebunny/crossref_metadata_2025_split huggingface dataset:
Fast Charging Lithium Metal Batteries with Liquid and Solid‐State Electrolytes
Authors: Park Kyobin , Song Juyeop , Lee Kyu Tae 
Published: October 2023

AbstractThe advent of fast charging technologies has revolutionized the field of energy storage, promising shorter charging times for lithium metal batteries. However, the pursuit of rapid charging capabilities presents several challenges, primarily due to the formation of lithium dendrites, which in turn, can lead to thermal runaway and safety risks. In this review, we first discuss the growth behavior of lithium metal in both liquid and solid‐state electrolytes. Then, we outline the challenges and recent progress in lithium metal batteries, particularly under fast charging conditions. Furthermore, we present comprehensive summary of the literatures on lithium metal batteries cycled at high current densities, investigating their performance with both liquid and solid‐state electrolytes. Finally, we propose perspectives on various strategies aimed at addressing the challenges associated with lithium metal batteries under fast charging conditions.
Matrix effect in bioanalytical assay development using supercritical fluid chromatography‐mass spectrometry
Authors: Chen Liuxi , Cui Yuxiang , Dean Brian , Liang Xiaorong 
Published: October 2023

AbstractMatrix effect (ME) is commonly caused by coelution of compounds with target analytes, resulting in either suppression or enhancement of analyte ionization. Thus, to achieve the desired accuracy, precision, and sensitivity, ME needs to be evaluated and controlled during bioanalytical method development. As the application of supercritical fluid chromatography‐mass spectrometry (SFC‐MS) for analysis of biological samples has increased, ME using SFC‐MS has also been investigated with a focus on the difference in ME in SFC‐MS compared to other chromatographic techniques used for achiral separation in biological samples. Here, we provide a summary of the status of ME evaluation and mitigation in SFC‐MS methods. This review presents an overview of the phenomenon of ME and methods for evaluating ME in bioanalysis. Next, the factors that can impact ME in SFC‐MS‐based bioanalytical methods are discussed in detail with an emphasis on SFC. A literature review of the evaluation of ME in targeted bioanalytical methods using SFC‐MS is included at the end. Robust instrumentation, effective sample preparation, and superb separation selectivity are the foundations of reliable analytical methods as well as the ability to mitigate detrimental ME in SFC‐MS methods.
Erythema multiforme provoked by radiotherapy
Authors: Machoń Natalia Joanna , Lewandowska Julia Alicja , Chojnacka‐Purpurowicz Joanna , Owczarczyk‐Saczonek Agnieszka 
Published: October 2023

Key Clinical MessageRadiation dermatitis is one of the most common adverse effects that occur in patients treated with radiation therapy. It is usually limited to the irradiated area. However, cases of generalized lesions have also been described in the literature. A rare but highly important cutaneous manifestation can be erythema multiforme‐like lesions localized all over the patient's skin. A 63‐year‐old patient was admitted to the Department of Dermatology for disseminated erythematous lesions localized on the trunk and extremities. The patient denied taking any new medications or dietary supplements. However, he was undergoing radiotherapy treatment. On admission, the patient was in good general condition. During the stay in the department, the patient was treated orally as well as intravenously with corticosteroids, acyclovir, and a topical ointment consisting of gentamicin and betamethasone, as well as hydrocortisone and cooling ointment. After 1 month, a significant improvement in the patient's skin condition was noted. When skin lesions resembling erythema multiforme occur in patients undergoing oncological treatment, radiation therapy should be considered as a potential trigger.
Partially involuting congenital hemangioma with pyogenic granuloma‐induced rapid progression following incisional biopsy in infancy: A case report
Authors: Sasaki Yuki , Ishikawa Kosuke , Miura Takahiro , Funayama Emi , Yamamoto Yuhei , Maeda Taku 
Published: October 2023

Key Clinical MessageWe present a case of partially involuting congenital hemangioma (PICH) that showed rapid growth with ulceration after incisional biopsy. PICH does not typically grow after birth. However, if growth occurs due to stimuli like biopsy, it is essential to consider the possibility of pyogenic granuloma complication.
Primary retroperitoneal solitary fibrous tumor: A case report
Authors: Shrestha Pramesh Prasad , Adhikari Mahesh Bahadur , Maharjan Bipin , Gautam Ravi Kiran , Basnet Birodh , Yadav Deepak Kumar 
Published: October 2023

Key Clinical MessagePrimary retroperitoneal masses have numerous differential diagnoses, many of which are rare entities. These can be neoplastic or nonneoplastic. Among the rare conditions are solitary fibrous tumors, which can either be benign or malignant. It is a mesenchymal, spindle‐cell tumor, reported first in 1931 as a pleural tumor by Klemperer et al. A 20‐year‐old lady, with abdominal pain for 6 months, was diagnosed with a retroperitoneal mass on the left lower abdomen on USG which was confirmed by an MRI scan of the abdomen. The patient underwent laparoscopy‐assisted excision of the mass. The final histopathological reports and immunohistochemistry reports revealed a solitary fibrous tumor. Solitary fibrous tumors (SFTs) are rare tumors in the retroperitoneum. In our search, fewer than a hundred cases have been reported. It has a characteristic “patternless pattern” in a microscopic study. Adverse outcomes of SFTs are associated with atypical features in histology, such as nuclear pleomorphism, necrosis, increased cellularity, and mitoses >4/10 HPF and size more than 10 cm. The standard of care is surgical excision with clear margins. Open surgeries have been done traditionally; we present a case where we performed the excision laparoscopically.
Concentration‐ and Solvent‐Induced Chiral Tuning by Manipulating Non‐Proteinogenic Amino Acids in Glycoconjugate Supra‐Scaffolds: Interaction with Protein, and Streptomycin Delivery
Authors: Ghosh Angshuman , Mandal Jishu , Dubey Soumen Kumar , Padma Somrita , Ghosh Narendra Nath , Behera Ashok , Hafiz Sk Abdul , Ruidas Pradip , Midya Ramkrishna , Roy Dipanwita , Das Dona , Das Surajit , Singh Somendra , Bhattacharyya Sankar , Mukherjee Suprabhat , Bhattacharjee Subham 
Published: October 2023

AbstractWe showed solvent‐ and concentration‐triggered chiral tuning of the fibrous assemblies of two novel glycoconjugates Z‐P(Gly)‐Glu and Z‐F(4‐N)‐Glu made by chemical attachment of Cbz‐protected [short as Z)] non‐proteinogenic amino acids L‐phenylglycine [short as P(Gly)] and 4‐Nitro‐L‐phenylalanine [short as F(4‐N)] with D‐glucosamine [short as Glu]. Both biomimetic gelators can form self‐healing and shape‐persistent gels with a very low critical gelator concentration in water as well as in various organic solvents, indicating they are ambidextrous supergelators. Detailed spectroscopic studies suggested β‐sheet secondary structure formation during anisotropic self‐aggregation of the gelators which resulted in the formation of hierarchical left‐handed helical fibers in acetone with an interlayer spacing of 2.4 nm. After the physical characterization of the gels, serum protein interaction with the gelators was assessed, indicating they may be ideal for biomedical applications. Further, both gelators are benign, non‐immunogenic, non‐allergenic, and non‐toxic in nature, which was confirmed by performing the blood parameters and liver function tests on Wister rats. Streptomycin‐loaded hydrogels showed efficacious antibacterial activity in vitro and in vivo as well. Finally, cell attachment and biocompatibility of the hydrogels were demonstrated which opens a newer avenue for promising biomedical and therapeutic applications.
Why the role of mHealth in allergy diagnosis and treatment adherence cannot be overlooked
Authors: Szylling Anna , Raciborski Filip , Wojas Oksana , Furmańczyk Konrad , Krzych‐Fałta Edyta , Bousquet Jean , Samoliński Boleslaw 
Published: October 2023

AbstractBackgroundAllergic diseases—rhinitis and asthma—are the most common chronic conditions affecting adults. Traditional approaches to allergy diagnosis and treatment do not meet the health needs of all patients. Treatment adherence remains a challenge for physicians. The ubiquity of Internet access paired with limited in‐person contact with medical personnel in the course of the COVID‐19 pandemic demonstrated the potential of mHealth in communicating health information.BodyThe abundance of new applications dedicated to various medical specialties encourages reflection on the informed use of such tools. The paper takes a closer look at the potential of mHealth and presents conclusions of selected studies focusing on the use of good apps. The strength weakness opportunities threats analysis was used to illustrate the strengths of the mHealth strategy, as well as its advantages, limitations and areas in need of further development.ConclusionThe strength of mHealth depends on the quality and quantity of the collected patient data, its reliable processing, as well as publication of outcomes and conclusions from analyses. Therefore, it is necessary to promote the use of validated applications among patients, physicians and medical staff.
Indeterminate pulmonary nodules in non‐rhabdomyosarcoma soft tissue sarcoma: A study of the European paediatric Soft Tissue Sarcoma Study Group
Authors: Giraudo Chiara , Schoot Reineke , Cardoen Liesbeth , Stramare Roberto , Coppadoro Beatrice , Bisogno Gianni , Bouhamama Amine , Brennan Bernadette , Brisse Herve J. , Orbach Daniel , Coma Ana , Di Paolo Pier Luigi , Fayard Cindy , McDonald Leigh , Moalla Salma , Morosi Carlo , Pace Erika , Tang Vivian , van Noesel Max M. , Ferrari Andrea , van Rijn Rick 
Published: October 2023

AbstractBackgroundThe aim of this study was to assess the clinical impact of indeterminate pulmonary nodules (no more than four pulmonary nodules of less than 5 mm or one nodule measuring between 5 and less than 10 mm by computed tomography [CT]) in children and adolescents with adult‐type non‐rhabdomyosarcoma soft tissue sarcoma (NRSTS) at diagnosis.MethodsPatients with NRSTS treated in 11 centers as part of the European paediatric Soft Tissue Sarcoma Study Group (EpSSG) were retrospectively assessed. Local radiologists, blinded to clinical information except for patients’ age and tumor histotype, reviewed the chest CT at diagnosis and filled out a case report form. Because patients with or without indeterminate nodules in the EpSSG NRSTS 2005 study received the same type of treatment, event‐free survival (EFS) and overall survival (OS) between groups by log‐rank test were compared.ResultsOverall, 206 patients were examined: 109 (52.9%) were without any nodules, 78 (38%) had at least one indeterminate nodule, and 19 (9.2%) had nodules meeting the definition of metastases, which were then considered to be misclassified and were excluded from further analyses. Five‐year EFS was 78.5% (95% CI, 69.4%–85.1%) for patients without nodules and 69.6% (95% CI, 57.9%–78.7%) for patients with indeterminate nodules (p = .135); 5‐year OS was 87.4% (95% CI, 79.3%–92.5%) and 79.0% (95% CI, 67.5%–86.8%), respectively (p = .086).ConclusionsThis study suggests that survival does not differ in otherwise nonmetastatic patients with indeterminate pulmonary nodules compared to nonmetastatic patients without pulmonary nodules.Plain Language Summary

Radiologists should be aware of the classification of indeterminate pulmonary nodules in non‐rhabdomyosarcoma soft tissue sarcomas and use it in their reports.
More than a third of patients with non‐rhabdomyosarcoma soft tissue sarcoma can be affected by indeterminate pulmonary nodules.
Indeterminate pulmonary nodules do not significantly affect the overall survival of pediatric patients with non‐rhabdomyosarcoma soft tissue sarcoma.
Dancing epilepsy: A stereo encephalography case report
Authors: Cámpora Nuria , Nasimbera Alejandro , Daza Anilu , Giagante Brenda , Oddo Silvia , Kochen Silvia 
Published: October 2023

AbstractIctal semiology is essential to identify the epileptogenic zone (EZ), especially in drug‐resistant focal epilepsy (DRE), as its accurate identification determines the surgical prognosis. Dancing is highly unusual ictal semiology, and its underlying neural networks remain somehow unclear since both temporal and frontal lobe (FL) have been implicated in its generation. We present a 21‐year‐old male with DRE characterized by dancing seizures. Homemade videos were obtained. Through a non‐invasive pre‐surgical evaluation, the epileptogenic zone was localized within a gross lesion in the left FL. Using stereo electroencephalography (SEEG), we successfully identified the ictal‐onset zone in the mesial middle, inferior, and orbito‐frontal cortex, with rapid propagation of ictal activity extending backward and laterally to the precentral regions. Subsequently, a left frontal middle and inferior gyrectomy was performed, resulting in seizure freedom for the patient. Pathology results revealed a mild malformation of cortical development with oligodendroglial hyperplasia (MOGHE). Atypical seizure semiology, such as dancing, provides an interesting starting point for the analysis of the areas involved in the EZ. Further intracranial recordings are required to fully comprehend the underlying networks and interactions of cerebral areas during dancing seizures.
The supplementation of Rothia as a potential preventive approach for bone loss in mice with ovariectomy‐induced osteoporosis
Authors: Li Ying‐Juan , Zhang Yuan‐Wei , Cao Mu‐Min , Zhang Ruo‐Lan , Wu Meng‐Ting , Rui Yun‐Feng , Liu Nai‐Feng 
Published: October 2023

AbstractThere is an inseparable link between bone metabolism and gut microbiota, and the supplementation of probiotics exhibits a significant role in maintaining the homeostasis of gut microbiota and inhibiting bone loss. This study aims to explore the preventive and therapeutic potentials and the specific mechanisms of Rothia on osteoporosis. The mice models of osteoporosis induced by ovariectomy (OVX) were built, and the regular (once a day) and quantitative (200 μL/d) gavage of Rothia was performed for 8 weeks starting from 1 week after OVX. Microcomputed tomography was used to analyze the bone mass and bone microstructure of mice in each group after sacrifice. Histological staining and immunohistochemistry were then applied to identify the expression of pro‐inflammatory cytokines, intestinal permeability, and osteogenic and osteoclastic activities of mice. The collected feces of mice in each group were used for 16S rRNA high‐throughput sequencing to detect the alterations in composition, abundance, and diversity of gut microbiota. This study demonstrated that the gavage of Rothia alleviated bone loss in mice with OVX‐induced osteoporosis, improved OVX‐induced intestinal mucosal barrier injury, optimized intestinal permeability (zonula occludens protein 1 and occludin), reduced intestinal inflammation (tumor necrosis factor‐α and interleukin‐1β), and regulated imbalance of gut microbiota. Based on “gut‐bone” axis, this study revealed that regular and quantitative gavage of Rothia can relieve bone loss in mice with OVX‐induced osteoporosis by repairing the intestinal mucosal barrier injury, optimizing the intestinal permeability, inhibiting the release of pro‐inflammatory cytokines, and improving the disorder of gut microbiota.
Transcriptome and proteomics conjoint analysis reveal anti‐alcoholic liver injury effect of Dianhong Black Tea volatile substances
Authors: Gao Tinghui , Fu JiaoJiao , Liu Lin , Bai Jing , Lv Yangjun , Zhu Yuejin , Lan Yu , Cao Xiaonian , Feng Huafang , Shen Caihong , Liu Sijing , Zhang Shikang , Guo Jinlin 
Published: October 2023

AbstractDianhong Black Tea, a fermented tea containing various bioactive ingredients, has been found to have a significant role in alleviating alcoholic liver injury (ALI). One of its main unique components, Dianhong Black Tea volatile substances (DBTVS), may have potential anti‐ALI effects. However, its effects and underlying molecular mechanisms are still unknown. In this study, we aimed to investigate the potential of DBTVS as an anti‐ALI agent using alcohol‐fed rats. We assessed the effect of DBTVS on ALI by analyzing serum transaminase and lipid levels, as well as conducting hematoxylin–eosin and oil red O staining. Additionally, GC‐MS was used to detect the components of DBTVS, while transcriptome, proteomics analysis, Western blot, and molecular docking were employed to uncover the underlying mechanisms. Our results demonstrated that DBTVS significantly reduced serum ALT and AST levels and improved lipid metabolism disorders. Moreover, we identified 14 components in DBTVS, with five of them exhibiting strong binding affinity with key proteins. These findings suggested that DBTVS could be a promising agent for the prevention and treatment of ALI. Its potential therapeutic effects may be attributed to its ability to regulate lipid metabolism through the PPAR signaling pathway.
Optimal oxygen excess ratio tracking of proton exchange membrane fuel cell with uncertainty based on robust model predictive control strategy
Authors: Zhang Xin , Zhang Chunlei , Zhang Zhijin , Li He 
Published: October 2023

AbstractTo address the challenge of tracking the optimal oxygen excess ratio (OER) in the cell stack cathode of the proton exchange membrane fuel cell (PEMFC), which is subject to norm‐bounded parameter uncertainty and frequent external perturbations, this manuscript provides a novel robust model predictive control strategy with a state feedback control structure and hard constraints. We aim to minimize the tracking error of OER while maximizing the net power under varying operational conditions of the PEMFC. Initially, a control‐oriented model for the air supply system is built and its accuracy is validated by comparing it with experimental results. Next, we construct the discrete state‐space equations for optimal control and employ the linear matrix inequality (LMI) method to transform the problem of difficult min‐max optimization solutions into a convex optimization problem with LMI constraints. Finally, the effectiveness of the proposed control algorithm is validated through simulation. The results demonstrate the strong robustness and superiority of the proposed controller against uncertainties in plant parameters for robust OER trajectory tracking. It improves the transient performance through robust precision tracking applications, which will eventually accelerate PEMFC commercialization.
Air pollution, weather factors, and realized volatility forecasts of agricultural commodity futures
Authors: Luo Jiawen , Zhang Qun 
Published: October 2023

AbstractThis study investigates the potential effects of environmental factors on fluctuations in agricultural commodity futures markets, by constructing a new category of daily exogenous predictors related to air pollution, weather, climate change, and investor attention. The empirical results from out‐of‐sample analyses suggest that the heterogeneous autoregressive (HAR) model incorporating all these exogenous predictors is more likely to outperform other HAR‐type models. Additionally, economic evaluations demonstrate the superior performance of models incorporating investors' attention to climate change or extreme weather as predictors. While not all exogenous predictors are equally important for volatility forecasts, adopting appropriate variable selection methods to handle different sets of exogenous predictors can lead to better performance than the HAR benchmark. With the inclusion of air pollution or weather factors in the HAR model, a portfolio with an annualized average excess return of 16.2068% or a Sharpe ratio of 10.0431 can be achieved for the wheat futures, respectively.
Tagraxofusp in myeloid malignancies
Authors: Bruzzese Antonella , Martino Enrica Antonia , Labanca Caterina , Mendicino Francesco , Lucia Eugenio , Olivito Virginia , Neri Antonino , Imovilli Annalisa , Morabito Fortunato , Vigna Ernesto , Gentile Massimo 
Published: October 2023

AbstractTagraxofusp (or SL‐401) is a recombinant molecule composed of human interleukin‐3 that binds CD123 on neoplastic cells fused to a truncated diphtheria toxin (DT). Tagraxofusp's most significant success has come from studies involving patients with blastic plasmacytoid dendritic cell neoplasm (BPDCN), an aggressive disease that is usually refractory to conventional chemotherapy. Tagraxofusp had an acceptable safety profile and high efficacy in early phase I/II studies on patients with BPDCN. Another phase II study confirmed the good response rates, resulting in Food and Drugs Administration and European Medicine Agency approval of tagraxofusp for the treatment of BPDCN. Considering its high efficacy and its manageable safety profile, tagraxofusp has been suddenly explored in other myeloid malignancies with high expression of cell surface CD123, both in monotherapy or combination strategies. The triplet tagraxofusp‐azacytidine‐venetoclax appears to be of particular interest among these combinations. Furthermore, combination strategies may be used to overcome tagraxofusp resistance. The downregulation of DPH1 (diphthamide biosynthesis 1), the enzyme responsible for the conversion of histidine 715 on eEF2 to diphthamide, which is then the direct target of ADP ribosylation DT, is typically associated with this resistance phenomenon. It has been discovered that azacitidine can reverse DHP1 expression and restore sensitivity to tagraxofusp. In conclusion, the success of tagraxofusp in BPDCN paved the way for its application even in other CD123‐positive malignancies. Nowadays, several ongoing trials are exploring the use of tagraxofusp in different myeloid neoplasms. This review aims to summarize the actual role of tagraxofusp in BPDCN and other CD123‐positive myeloid malignancies.
Thermal analysis of fully wetted porous longitudinal fin of parabolic profile with variable thermal conductivity and convection–radiation
Authors: Usha B. , Gireesha B. J. 
Published: October 2023

AbstractThe thermal performance of a fully wetted porous fin with concave parabolic cross section is explored in this study for variable thermal conductivity. We have considered convective and radiative heat transfer with variations of temperature‐dependent surface emissivity, internal heat generation, heat transfer coefficient, and magnetic field effect on the thermal profile of the fin. The heat transfer equation is derived from Darcy's model. Nondimensional governing ordinary differential equation is attempted by Runge–Kutta–Fehlberg technique. Influences of associated parameters on the cooling performance of fin are explored through graphs. From this study, it was found that the rate of heat transfer from the fin whose thermal conductivity varies linearly with temperature is twice than that of the fin with exponential dependency on thermal conductivity in the presence of magnetic effect.