bluuebunny/crossref_metadata_2025_split huggingface dataset:
Policy whiplash: How California Title IX coordinators navigated local, state, and federal policy changes during the Trump administration
Authors: Eriksen Shelley J. , Valdivia Rebecca L. Howard , Chib Sheetal S. 
Published: February 2024

AbstractFederal Title IX policy requires institutions of higher education (IHEs) to prevent and respond to sexual misconduct. Based on 23 in‐depth interviews, this study explores California Title IX coordinator experiences at a critical policy juncture—the recension of the Obama‐era guidance and the implementation of the Trump administration Title IX rules and regulations—to understand how they responded to, implemented, or resisted federal mandates. Most California Title IX officers reported that the recension of Obama guidelines had limited impact on their daily operations because they lived in a state with more progressive social policy. Participants singled out California case law, state statues, the California Education Code and university system mandates as protective legislation to ensure survivors’ rights. By contrast, the new Title IX regulations that became law in August 2020 were perceived as more consequential. The tight implementation time frame, combined with the complicated and unfunded policy directives, imposed heavy burdens on their administrative offices. Title IX officers foresaw implementation consequences to campus safety, survivors’ willingness to report, and to the credibility of the Title IX office. Taken together, their experiences lend support to progressive state legislative action, restorative justice approaches and for a survivor bill of rights as important counterpoints to federal Title IX policy.
Pharmacology of erenumab in human isolated coronary and meningeal arteries: Additional effect of gepants on top of a maximum effect of erenumab
Authors: de Vries Tessa , Rubio‐Beltrán Eloísa , van den Bogaerdt Antoon , Dammers Ruben , Danser A. H. Jan , Snellman Josefin , Bussiere Jeanine , MaassenVanDenBrink Antoinette 
Published: February 2024

AbstractBackground and PurposeMultiple drugs targeting the calcitonin gene‐related peptide (CGRP) receptor have been developed for migraine treatment. Here, the effect of the monoclonal antibody erenumab on CGRP‐induced vasorelaxation was investigated in human isolated blood vessels, as well as the effect of combining erenumab with the small molecule drugs, namely rimegepant, olcegepant, or sumatriptan.Experimental ApproachConcentration–response curves to CGRP, adrenomedullin or pramlintide were constructed in human coronary artery (HCA) and human middle meningeal artery (HMMA) segments, incubated with or without erenumab and/or olcegepant. pA2 or pKb values were calculated to determine the potency of erenumab in both tissues. To study whether acutely acting antimigraine drugs exerted additional CGRP‐blocking effects on top of erenumab, HCA segments were incubated with a maximally effective concentration of erenumab (3 μM), precontracted with KCl and exposed to CGRP, followed by rimegepant, olcegepant, or sumatriptan in increasing concentrations.Key ResultsErenumab shifted the concentration‐response curve to CGRP in both vascular tissues. However, in HCA, the Schild plot slope was significantly smaller than unity, whereas this was not the case in HMMA, indicating different CGRP receptor mechanisms in these tissues. In HCA, rimegepant, olcegepant and sumatriptan exerted additional effects on CGRP on top of a maximal effect of erenumab.Conclusions and ImplicationsGepants have additional effects on top of erenumab for CGRP‐induced relaxation and could be effective in treating migraine attacks in patients already using erenumab as prophylaxis.
Wound‐healing agents for palatal donor area: A network meta‐analysis
Authors: Oliveira Jovânia Alves , da Silveira Marcela Iunes , Soares Lélio Fernando Ferreira , Alves Roberta de Oliveira , Carrera Thaísa Macedo Iunes , Azevedo Mayra Resende , Oliveira Guilherme José Pimentel Lopes de , Pigossi Suzane Cristina 
Published: February 2024

AbstractBackgroundThe aim of this systematic review and network meta‐analysis (NMA) was to assess the efficacy of different wound‐healing agents for palatal donor area management after soft tissue graft harvesting.MethodsElectronic searches in six databases were conducted for publications up to October 2023. Studies with data from patients undergoing therapeutic approaches using agents for palatal healing after gingival graft harvesting were included. Data about postoperative pain, wound‐healing and postoperative complications reported for each agent were extracted. Three different tools were used for the risk of bias within studies evaluation (Murad tool for case series and case report, RoB 2.0 tool for randomized studies and ROBINS‐I tool for non‐randomized studies). A Bayesian random effects NMA was conducted for postoperative pain levels and wound healing.ResultsEighty‐four publications were included in the systematic review (qualitative analysis), with 14 of these subjected to NMA (quantitative analysis). The summarized results from the qualitative and quantitative analysis showed that all wound‐healing agents evaluated promoted better pain control and wound healing compared to spontaneous healing and hemostatic sponges alone. The NMA outcomes reveal that leucocyte‐ and platelet‐rich fibrin (L‐PRF) was the most effective agent in reducing postoperative pain in all analyzed periods. Moreover, the L‐PRF seems to accelerate wound healing and reduce postoperative complications compared to other agents.ConclusionIn conclusion, the L‐PRF was the most effective agent in reducing postoperative pain, accelerating wound healing and reducing postoperative complications after harvesting soft tissue grafts from the palatal area.
Laparoscopic polyglycolic acid spacer placement for locally recurrent rectal cancer
Authors: Kobayashi Toshinori , Sekimoto Mitsugu , Miki Hisanori , Yamamoto Nobuyuki , Harino Takashi , Yagyu Takuki , Hori Soshi , Hatta Masahiko , Hashimoto Yuki , Kotsuka Masaya , Yamasaki Makoto , Inoue Kentaro 
Published: February 2024

AbstractCarbon ion radiotherapy (CIRT) has received attention for the treatment of locally recurrent rectal cancer. When the surrounding primary organs are close to the irradiation site, a spacer is required to ensure safe irradiation. This work describes a novel technique using a bioabsorbable polyglycolic acid spacer placed laparoscopically and presents a technical report with five case studies. The short‐term surgical outcomes were as follows: mean operating time 235 min with blood loss of 38 mL. CIRT was planned, and the patients underwent irradiation within 2 months of surgery. No pelvic infections occurred, and all procedures were performed safely. Herein, were present a technical report with reference to a video of the surgical procedure.
Single‐cell RNA sequencing reveals immune cell dysfunction in the peripheral blood of patients with highly aggressive gastric cancer
Authors: Ma Rui , Zhou Xuemeng , Zhai Xiaohui , Wang Chuyue , Hu Rong , Chen You , Shi Liyang , Fang Xing , Liao Yuan , Ma Lifeng , Jiang Mengmeng , Wu Junqing , Wang Renying , Chen Jiao , Cao Taiyuan , Du Ge , Zhao Yingying , Wu Weili , Chen Haide , Li Shanshan , Lian Qizhou , Guo Guoji , Xiao Jian , Hutchins Andrew P. , Yuan Ping 
Published: February 2024

AbstractHighly aggressive gastric cancer (HAGC) is a gastric cancer characterized by bone marrow metastasis and disseminated intravascular coagulation (DIC). Information about the disease is limited. Here we employed single‐cell RNA sequencing to investigate peripheral blood mononuclear cells (PBMCs), aiming to unravel the immune response of patients toward HAGC. PBMCs from seven HAGC patients, six normal advanced gastric cancer (NAGC) patients, and five healthy individuals were analysed by single‐cell RNA sequencing. The expression of genes of interest was validated by bulk RNA‐sequencing and ELISA. We found a massive expansion of neutrophils in PBMCs of HAGC. These neutrophils are activated, but immature. Besides, mononuclear phagocytes exhibited an M2‐like signature and T cells were suppressed and reduced in number. Analysis of cell‐cell crosstalk revealed that several signalling pathways involved in neutrophil to T‐cell suppression including APP‐CD74, MIF‐(CD74+CXCR2), and MIF‐(CD74+CD44) pathways were increased in HAGC. NETosis‐associated genes S100A8 and S100A9 as well as VEGF, PDGF, FGF, and NOTCH signalling that contribute to DIC development were upregulated in HAGC too. This study reveals significant changes in the distribution and interactions of the PBMC subsets and provides valuable insight into the immune response in patients with HAGC. S100A8 and S100A9 are highly expressed in HAGC neutrophils, suggesting their potential to be used as novel diagnostic and therapeutic targets for HAGC.
Additional Cover
Authors: Csukovich Georg , Wagner Maximilian , Walter Ingrid , Burger Stefanie , Tschulenk Waltraud , Steinborn Ralf , Pratscher Barbara , Burgener Iwan Anton 
Published: February 2024

The cover image is based on the Original Article Polarity reversal of canine intestinal organoids reduces proliferation and increases cell death by Georg Csukovich et al., https://doi.org/10.1111/cpr.13544. Image Credit: Georg Csukovich.
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Approaches and reporting of alcohol and other drug testing for injured patients in hospital‐based studies: A systematic review
Authors: Lau Georgina , Ang Jia Y. , Kim Nayoung , Gabbe Belinda J. , Mitra Biswadev , Dietze Paul M. , Reeder Sandra , Beck Ben 
Published: February 2024

AbstractIssueHospital alcohol and/or other drug (AOD) testing is important for identifying AOD‐related injuries; however, testing methods vary. This systematic review aimed to examine biological AOD testing methods from hospital‐based studies of injured patients and quantify what proportion reported key information on those testing methods.ApproachObservational studies published in English from 2010 onwards involving biological AOD testing for injured patients presenting to hospital were included. Studies examining single injury causes were excluded. Extracted data included concentration thresholds for AOD detection (e.g., lower limits of detection, author‐defined cut‐offs), test type (e.g., immunoassay, breathalyser) and approach (e.g., routine, clinical discretion), timing of testing, sample type and the proportion of injured cases tested for AODs.Key FindingsOf 83 included studies, 76 measured alcohol and 37 other drugs. Forty‐nine studies defined blood alcohol concentration thresholds (ranging from 0 to 0.1 g/100 mL). Seven studies defined concentration thresholds for other drugs. Testing approach was reported in 39/76 alcohol and 18/37 other drug studies. Sample type was commonly reported (alcohol: n = 69/76; other drugs: n = 28/37); alcohol was typically measured using blood (n = 60) and other drugs using urine (n = 20). Studies that reported the proportion of cases tested (alcohol: n = 53/76; other drugs: n = 28/37), reported that between 0% and 89% of cases were not tested for alcohol and 0% and 91% for other drugs. Timing of testing was often unreported (alcohol: n = 61; other drugs: n = 30).Implications and ConclusionVariation in AOD testing methods alongside incomplete reporting of those methods limits data comparability and interpretation. Standardised reporting of testing methods will assist AOD‐related injury surveillance and prevention.
Higher early pregnancy plasma myo‐inositol associates with increased postprandial glycaemia later in pregnancy: Secondary analyses of the NiPPeR randomized controlled trial
Authors: Chan Shiao‐Yng , Zhang Han , Wong Jui‐Tsung , Chang Hsin F. , Chen Ling‐Wei , Barton Sheila J. , Nield Heidi , El‐Heis Sarah , Kenealy Timothy , Lavalle Luca , Ramos‐Nieves J. Manuel , Godin Jean‐Philippe , Silva‐Zolezzi Irma , Cutfield Wayne S. , Godfrey Keith M. ,   NiPPeR Study Group
Published: February 2024

AbstractAimMyo‐inositol supplementation from ~13 weeks' gestation reportedly improves glycaemia regulation in metabolically at‐risk women, with speculation that earlier supplementation might bring further improvement. However, the NiPPeR trial of a myo‐inositol‐containing supplement starting preconception did not lower gestational glycaemia in generally healthy women. We postulated that the earlier timing of supplementation influences the maternal metabolic adaptation for gestational glycaemia regulation.MethodsIn total, 585 women were recruited from Singapore, UK and New Zealand for the NiPPeR study. We examined associations of plasma myo‐inositol concentrations at 7 and 28 weeks' gestation with 28 weeks plasma glucose (PG; fasting, and 1 h and 2 h in 75 g oral glucose tolerance test) and insulin indices using linear regression adjusting for covariates.ResultsHigher 7‐week myo‐inositol, but not 28‐week myo‐inositol, associated with higher 1 h PG [βadj (95% confidence intervals) 0.05 (0.01, 0.09) loge mmol/L per loge μmol/L, p = .022] and 2 h PG [0.08 (0.03, 0.12), p = .001]; equivalent to 0.39 mmol/L increase in 2 h PG for an average 7‐week myo‐inositol increase of 23.4 μmol/L with myo‐inositol supplementation. Higher 7‐week myo‐inositol associated with a lower 28‐week Stumvoll index (first phase), an approximation of insulin secretion [−0.08 (−0.15, −0.01), p = .020] but not with 28‐week Matsuda insulin sensitivity index. However, the clinical significance of a 7‐week myo‐inositol‐related increase in glycaemia was limited as there was no association with gestational diabetes risk, birthweight and cord C‐peptide levels. In‐silico modelling found higher 28‐week myo‐inositol was associated with lower gestational glycaemia in White, but not Asian, women after controlling for 7‐week myo‐inositol effects.ConclusionTo our knowledge, our study provides the first evidence that increasing first trimester plasma myo‐inositol may slightly exacerbate later pregnancy post‐challenge glycaemia, indicating that the optimal timing for starting prenatal myo‐inositol supplementation needs further investigation.
Economic evaluations of treatment of depressive disorders in adolescents: Protocol for a scoping review
Authors: Courtney Darren , Mason Joyce , Amani Bahar , Rodak Terri , Szatmari Peter , Henderson Jo , de Oliveira Claire 
Published: February 2024

AbstractAimDepressive disorders in adolescents are common and impairing. Evidence‐based treatments are available; however, at a cost. In the context of the COVID‐19 pandemic, we anticipate increased demand for treatment services for adolescents with depression. We also anticipate that economic resources will be strained. Identifying cost‐effective strategies to optimally treat depression in adolescents is imperative. This protocol for a scoping review aims to describe the literature with respect to economic evaluations of treatments for depression in adolescents.MethodsWe will conduct a scoping review using established methods and reporting guidelines. MEDLINE, Embase, PsyclNFO, Econlit, and the International HTA Database will be searched from inception to June 13, 2023, with an update closer to time of manuscript submission, while the NHS Economic Evaluation Database archives will be searched from inception to December 2014. Publications that contain economic evaluations, in the context of a clinical trial or a model‐based study, testing a treatment of depression in adolescents will be selected for inclusion. Extracted data items will include: economic evaluation perspectives, health outcome variables and costs used in economic evaluations, types of analyses performed, as well as quality of reporting and methodology.ResultA narrative synthesis with summary tables will be used to describe our findings.ConclusionOur findings will help identify gaps in the literature with respect to economic analyses for the treatment of depression such that these gaps can be filled with future research. Policy‐makers, funders and administrators may also use our findings to inform their decisions around provision of various treatments for depression in adolescents.Registrationosf.io/5fteb (note that information on this link will be updated upon acceptance for publication based on reviewer comments).
Dimensions and predictors of clinical and personal recovery in first‐episode psychoses: Results from a cross‐sectional study
Authors: Ferrara Maria , Zaffarami Giulia , Simonelli Gabriele , Domenicano Ilaria , Vecchioni Ludovica , Toffanin Tommaso , Folesani Federica , Zotos Spyridon , Scrignoli Chiara , Bertelli Raffaella , Carozza Paola , Grassi Luigi 
Published: February 2024

AbstractIntroductionFirst episode psychosis (FEP) services ensure higher recovery rates compared to usual care. The aim of this study was to investigate the different dimensions of recovery and its predictors.MethodsThis cross‐sectional study recruited within those admitted to the Ferrara FEP service since 2012 that at the time of analysis were still receiving psychiatric care. At admission, demographic, social and clinical information were collected. In September 2022, patients were assessed with the Health of the Nation Outcome Scale to evaluate clinical/functional recovery, the Recovery Assessment Scale to evaluate personal recovery, and the G12 item of the Positive and Negative Syndrome Scale to evaluate insight. Patients in recovery were compared to those not in recovery by bivariate analyses. Adjusted logistic regressions were performed to investigate predictors of recovery.ResultsWithin 141 admitted, and 105 still receiving care, 54 patients completed the assessment. Most (51.9%) were in clinical/functional, 61.1% in personal recovery, and 38.8% both. Psychiatric hospitalization positively predicted clinical/functional recovery, whereas being prescribed oral antipsychotics was a negative predictor. Personal recovery was predicted by male sex and showed a negative association with overall severity of symptomatology. Those in personal recovery were more likely to have been prescribed long‐acting antipsychotics, but this was not significant in the multivariable analysis. Poor insight negatively predicted clinical/functional recovery but had no impact on personal recovery.ConclusionOur findings confirm that clinical/functional and personal recovery are semi‐independent dimensions and not always overlap. Further research is needed to promote interventions targeted at all recovery dimensions.
The dark triad and entrepreneurial intention: The moderating role of family business exposure
Authors: Laouiti Rahma , Nakara Walid A. , Razgallah Meriam 
Published: February 2024

AbstractA substantial body of research has documented that personality traits, namely, negative personality traits generally known as the dark triad, play a significant role in determining entrepreneurial intention. However, despite the important role that parents play in the construction of their children's personality traits, studies examining the role of family business exposure on these socially aversive traits and its effect on the development of entrepreneurial intention are rarely developed. The current research is set to fill this gap through a quantitative approach based on a sample of 896 students. More specifically, we test the moderating effect of family business exposure on the relationship between dark triad personality traits and entrepreneurial intention. Our results provide evidence that narcissism and psychopathy have a direct effect on entrepreneurial intention and that family business exposure moderates the relationship between Machiavellianism and entrepreneurial intention. Several implications for educators and public policies are discussed.
The epidemiology and societal costs of myasthenia gravis in Norway: A non‐interventional study using national registry data
Authors: Engebretsen Ingrid , Gilhus Nils Erik , Kristiansen Ivar Sønbø , Sæther Erik Magnus , Lindberg‐Schager Ingrid , Arneberg Fredrik , Bugge Christoffer 
Published: February 2024

AbstractBackground and purposeWith the emergence of new treatment options for myasthenia gravis (MG), there is a need for information regarding epidemiology, healthcare utilization, and societal costs to support economic evaluation and identify eligible patients. We aimed to enhance the understanding of these factors using nationwide systematic registry data in Norway.MethodsWe received comprehensive national registry data from five Norwegian health‐ and work‐related registries. The annual incidence and prevalence were estimated for the period 2013–2021 using nationwide hospital and prescription data. The direct, indirect (productivity losses) and intangible costs (value of lost life‐years [LLY] and health‐related quality of life [HRQoL]) related to MG were estimated over a period of 1 year.ResultsIn 2021, the incidence of MG ranged from 15 to 16 cases per year per million population depending on the registry used, while the prevalence varied between 208.9 and 210.3 per million population. The total annual societal costs of MG amounted to EUR 24,743 per patient, of which EUR 3592 (14.5%) were direct costs, EUR 8666 (35.0%) were productivity loss, and EUR 12,485 (50.5%) were lost value from LLY and reduced HRQoL.ConclusionThe incidence and prevalence of MG are higher than previously estimated, and the total societal costs of MG are substantial. Our findings demonstrate that productivity losses, and the value of LLY and HRQoL constitute a considerable proportion of the total societal costs.
Tracing topics and trends in drug‐resistant epilepsy research using a natural language processing–based topic modeling approach
Authors: Karabacak Mert , Jagtiani Pemla , Jain Ankita , Panov Fedor , Margetis Konstantinos 
Published: February 2024

AbstractEpilepsy is a common neurological disorder affecting over 70 million people worldwide. Although many patients achieve seizure control with anti‐epileptic drugs (AEDs), 30%–40% develop drug‐resistant epilepsy (DRE), where seizures persist despite adequate trials of AEDs. DRE is associated with reduced quality of life, increased mortality and morbidity, and greater socioeconomic challenges. The continued intractability of DRE has fueled exponential growth in research that aims to understand and treat this serious condition. However, synthesizing this vast and continuously expanding DRE literature to derive insights poses considerable difficulties for investigators and clinicians. Conventional review methods are often prolonged, hampering the timely application of findings. More‐efficient approaches to analyze the voluminous research are needed. In this study, we utilize a natural language processing (NLP)–based topic modeling approach to examine the DRE publication landscape, uncovering key topics and trends. Documents were retrieved from Scopus, preprocessed, and modeled using BERTopic. This technique employs transformer models like BERT (Bidirectional Encoder Representations from Transformers) for contextual understanding, thereby enabling accurate topic categorization. Analysis revealed 18 distinct topics spanning various DRE research areas. The 10 most common topics, including “AEDs,” “Neuromodulation Therapy,” and “Genomics,” were examined further. “Cannabidiol,” “Functional Brain Mapping,” and “Autoimmune Encephalitis” emerged as the hottest topics of the current decade, and were examined further. This NLP methodology provided valuable insights into the evolving DRE research landscape, revealing shifting priorities and declining interests. Moreover, we demonstrate an efficient approach to synthesizing and visualizing patterns within extensive literature that could be applied to other research fields.