bluuebunny/crossref_metadata_2025_split huggingface dataset:
Effect of hemoglobin A1c management levels on coronary physiology evaluated by quantitative flow ratio in patients who underwent percutaneous coronary intervention
Authors: Chen Mingfeng , Liu Jichen , Xie Zhangxin , Chen Wei , Hu Yanqin , Wen Junping , Chen Jinyan , Chen Xuemei , Lin Lirong , Wang Rehua , Lu Lihong 
Published: November 2023

ABSTRACTAims/IntroductionThe coronary physiology and prognosis of patients with different hemoglobin A1c (HbA1c) levels after percutaneous coronary intervention (PCI) are currently unknown. The aim of this study was to assess the effect of different levels of HbA1c control on coronary physiology in patients who underwent PCI for coronary heart disease combined with type 2 diabetes mellitus by quantitative flow ratio (QFR).Materials and MethodsPatients who successfully underwent PCI and completed 1‐year coronary angiographic follow up were enrolled, clinical data were collected, and QFR at immediate and 1‐year follow up after PCI was retrospectively analyzed. A total of 257 patients (361 vessels) were finally enrolled and divided into the hemoglobin A1c (HbA1c)‐compliance group (103 patients, 138 vessels) and non‐HbA1c‐compliance group (154 patients, 223 vessels) according to the HbA1c cut‐off value of 7%. We compared the results of QFR analysis and clinical outcomes between the two groups.ResultsAt 1‐year follow up after PCI, the QFR was significantly higher (0.94 ± 0.07 vs 0.92 ± 0.10, P = 0.019) and declined less (0.014 ± 0.066 vs 0.033 ± 0.095, P = 0.029) in the HbA1c‐compliance group. Meanwhile, the incidence of physiological restenosis was lower in the HbA1c‐compliance group (2.9% vs 8.5%, P = 0.034). Additionally, the target vessel revascularization rate was lower in the HbA1c‐compliance group (6.8% vs 16.9%, P = 0.018). Furthermore, HbA1c ≥7% (OR 2.113, 95% confidence interval 1.081–4.128, P = 0.029) and QFR decline (OR 2.215, 95% confidence interval 1.147–4.277, P = 0.018) were independent risk factors for target vessel revascularization.ConclusionPatients with well‐controlled HbA1c levels have better coronary physiological benefits and the incidence of adverse clinical outcome events might be reduced.
Automated classification of hidradenitis suppurativa disease severity by convolutional neural network analyses using calibrated clinical images
Authors: Wiala A. , Ranjan R. , Schnidar H. , Rappersberger K. , Posch C. 
Published: November 2023

AbstractBackgroundThe assessment of hidradenitis suppurativa (HS) severity requires detailed, and error‐prone lesion counts. This proof‐of‐concept study aimed to automatically classify HS disease severity using machine learning of clinical smartphone images.Methods777 ambient‐light and size‐controlled images were used to build a class‐balanced synthetic dataset (n = 7675). Convolutional neural networks (CNN) were used for automated severity classification (scale 0–3), and to assess disease‐dynamics. International Hidradenitis Suppurativa Severity Score System (IHS4) served as reference. A U‐NET algorithm was implemented for automated localization of diseased skin.ResultsCNNs were able to distinguish no/mild from moderate/severe disease with an overall prediction accuracy of 78% [receiver operating curve (AUC) 0.85]. Correct IHS4 classification was achieved with an overall accuracy of 72% (AUC 0.84–0.89). In addition, disease dynamics using IHS4 numerical values aligned with CNN outputs (NRMSE 0.262). The UNET algorithm localized lesions with a pixel accuracy of 88.1% and test loss of 0.42.LimitationsLimitations in assessing tattooed and hairy skin. Limited number of patients with dark skin colour and Hurley I.ConclusionCNNs were able to distinguish no/mild from moderate/severe disease, classify disease severity over time, and automatically identify diseased skin areas and the skin phototype. This study breaks new grounds for fast, reliable, reproducible and easy‐to‐use HS severity assessments using clinical images.
A comprehensive review of nondermatophyte mould onychomycosis: Epidemiology, diagnosis and management
Authors: Gupta Aditya K. , Wang Tong , Cooper Elizabeth A. , Summerbell Richard C. , Piguet Vincent , Tosti Antonella , Piraccini Bianca Maria 
Published: November 2023

AbstractNondermatophyte moulds (NDMs) are widely distributed and can be detected in association with mycotic nails; however, sometimes it can be challenging to establish the role of NDMs in the pathogenesis of onychomycosis (i.e. causative vs. contaminant). In studies where the ongoing invasive presence of NDMs is confirmed through repeat cultures, the global prevalence of NDMs in onychomycosis patients is estimated at 6.9% with the 3 most common genus being: Aspergillus, Scopulariopsis and Fusarium. NDM onychomycosis can, in many cases, appear clinically indistinguishable from dermatophyte onychomycosis. Clinical features suggestive of NDMs include proximal subungual onychomycosis with paronychia associated with Aspergillus spp., Fusarium spp. and Scopulariopsis brevicaulis, as well as superficial white onychomycosis in a deep and diffused pattern associated with Aspergillus and Fusarium. Longitudinal streaks seen in patients with distal and lateral onychomycosis may serve as an additional indicator. For diagnosis, light microscopic examination should demonstrate fungal filaments consistent with an NDM with at least two independent isolations in the absence of a dermatophyte; the advent of molecular testing combined with histological assessment may serve as an alternative with improved sensitivity and turnover time. In most instances, antifungal susceptibility testing has limited value. Information on effective treatments for NDM onychomycosis is relatively scarce, unlike the situation in the study of dermatophyte onychomycosis. Terbinafine and itraconazole therapy (continuous and pulsed) appear effective to varying extents for treating onychomycosis caused by Aspergillus, Fusarium or Scopulariopsis. There is scant literature on oral treatments for Neoscytalidium.
Use of both the diode and Er: YAG lasers in esthetic crown lengthening with the aid of digitally guided dual technique: 3 years follow‐up
Authors: Benítez Carlos Guillermo , Azevedo Luciane Hiramatsu , da Silva Isabela Lopes Santos , de Oliveira Lima Mirella , Yanai Fernanda Yoshiko , Llanos Alexandre Hugo 
Published: November 2023

AbstractObjectiveTo explore the feasibility of the usage of digital guides in combination with low‐ and high‐power lasers for the treatment of excessive gingival display, also known as “gummy smile”.Clinical ConsiderationsExcessive gingival display due to altered passive eruption can affect patient's perception of their own esthetics and consequently have an impact on self‐confidence. Therefore, the management of this condition should offer a predictable and stable long‐lasting solution. To attain these objectives, digital planning emerges as a tool in optimizing the outcomes of crown lengthening surgery for this condition by enhancing precision through the use of surgical guides. Additionally, the usage of high‐ and low‐powered lasers can provide a safe approach because of their tissue selective removal properties.ConclusionsThe technique described showed satisfactory clinical results in the short‐ and long‐term follow‐up, leading to an improvement in patients' self‐esteem. This approach integrates digital and laser technologies to deliver a surgical treatment characterized by precision, efficiency, and safety.Clinical SignificanceDigital dentistry has contributed to innovative dental procedures, as personalizing surgical guides for patients, assisting and guiding incisions of the gingival margins, as well as the extension of the osteotomy, during the procedures for increasing the clinical crown. Furthermore, smile esthetics are directly related to an individual's improved emotional and social quality of life.
Effect of natural agents on the bond strength to eroded dentin
Authors: Romano Laryssa Karla , Soares Eduardo José , Alves Amorim Ayodele , Geng Vivanco Rocio , Pires‐de‐Souza Fernanda de Carvalho Panzeri 
Published: November 2023

AbstractObjectiveThis study evaluated the effect of bromelain and propolis extract on the bond strength (BS) of a universal adhesive system to eroded dentin.Materials and MethodsSixty human molars with exposed dentin were halved, with one half protected by composite resin and the other subjected to erosive treatment followed by remineralization. After the erosive treatment, the composite resin was removed, and the teeth were randomly assigned to three groups (n = 20): Adhesive‐Control System; Br‐10%; Pr‐16%. Following the treatments, composite resin blocks were built on the dentin surfaces and sticks of 0.9 mm2 were obtained and stored in distilled water at 37°C for 24 h and 6 months. After these periods, the sticks underwent bond strength testing and the data were analyzed using 2‐way ANOVA, Bonferroni test, p < 0.05. Fracture patterns were observed using light microscope and scanning electron microscopy.ResultsIrrespective of the substrate and aging duration, propolis demonstrated higher BS (p < 0.05) compared to the other treatments. Eroded dentin exhibited greater removal of the smear layer and dentinal tubules with a larger diameter than sound dentin, especially when treated with bromelain, resulting in the formation of resin tags.ConclusionsPropolis consistently promoted the highest bond strength, irrespective of aging or substrate. Eroded dentin treated with propolis, or bromelain exhibited a higher prevalence of non‐adhesive fractures and resin tag formation.Clinical SignificancePropolis shows promise for enhancing the longevity of adhesive restorations in eroded dentin due to its ability to promote high bond strength.
The capacity of conservative preparations for lithium disilicate glass–ceramic laminates luted with different resin cements to mask different substrate shades: A minimally invasive esthetic approach
Authors: da Silva Samara Franco , de Araújo Régis Mylena , Francci Carlos Eduardo 
Published: November 2023

AbstractObjectiveDemonstrate the ability of 0.5 mm thickness lithium disilicate laminates associated with resin cement to mask different substrate saturations.Methods60 specimens (n = 5) were prepared with CAD/CAM lithium disilicate glass–ceramic IPS e.max CAD, 0.5 mm thick, in three degrees of translucency (HT, MT and LT); cemented by Variolink Esthetic LC Light+ (L) and Neutral (N) on composite resin substrates A1 and A4 shades. Color measurements were performed by a spectrophotometer (CM‐3700d ‐Konica Minolta). The L*, a*, b* parameters of the tri‐layer structure (laminate/ resin cement/ substrate) were used to calculate color difference () by CIEDE2000 formula and Translucency Parameter (). This study adopted = 0.8, as perceptibility threshold (PT), and = 1.8, as acceptability threshold (AT). Statistical analyses were performed by one‐way ANOVA and Tukey tests (a = 0.05).ResultsColor difference between resin cement shades showed statistical differences (p < 0.0001) and > 1.8 for all groups. Color difference between substrates saturations showed a significant statistical difference (p < 0.0001) and values above AT for all groups. The demonstrated significant statistical differences (p < 0.0001). The LTL combination, the opaquest set, showed the smallest values between substrate shades differences, however, above AT.ConclusionThe translucency of the lithium disilicate, the substrate saturation and the resin cement opacity influenced final color of restoration. The ceramic translucency impact on final color was reduced by opaque resin cement. Furthermore, the LT lithium disilicate and the Light+ resin cement reduced the translucency of the restoration, contributing to mask saturated substrate.Clinical RelevanceThis study shows the influence of conservative lithium disilicate laminates with different degrees of translucency associated with resin cement on final color of saturated substrate restorations. A minimally invasive esthetic protocol for masking substrates is demonstrated by associating low translucency ceramic laminates and opaque resin cement.
Selection and characterization of ssDNA aptamer targeting Macrobrachium rosenbergii nodavirus capsid protein: A potential capture agent in gold‐nanoparticle‐based aptasensor for viral protein detection
Authors: Ghadin Norazli , Yusof Nur Afiqah Md , Syarul Nataqain Baharum , Raston Nurul Hanun Ahmad , Low Chen Fei 
Published: November 2023

AbstractThe giant freshwater prawn holds a significant position as a valuable crustacean species cultivated in the aquaculture industry, particularly well‐known and demanded among the Southeast Asian countries. Aquaculture production of this species has been impacted by Macrobrachium rosenbergii nodavirus (MrNV) infection, which particularly affects the larvae and post‐larvae stages of the prawn. The infection has been recorded to cause mortality rates of up to 100% among the affected prawns. A simple, fast, and easy to deploy on‐site detection or diagnostic method is crucial for early detection of MrNV to control the disease outbreak. In the present study, novel single‐stranded DNA aptamers targeting the MrNV capsid protein were identified using the systematic evolution of ligands by exponential enrichment (SELEX) approach. The aptamer was then conjugated with the citrate‐capped gold nanoparticles (AuNPs), and the sensitivity of this AuNP‐based aptasensor for the detection of MrNV capsid protein was evaluated. Findings revealed that the aptamer candidate, APT‐MrNV‐CP‐1 was enriched throughout the SELEX cycle 4, 9, and 12 with the sequence percentage of 1.76%, 9.09%, and 12.42%, respectively. The conjugation of APT‐MrNV‐CP‐1 with citrate‐capped AuNPs exhibited the highest sensitivity in detecting the MrNV capsid protein, where the presence of 62.5 nM of the viral capsid protein led to a significant agglomeration of the AuNPs. This study demonstrated the practicality of an AuNP‐based aptasensor for disease diagnosis, particularly for detecting MrNV infection in giant freshwater prawns.
A scoping review of research on polyamory and consensual non‐monogamy: Implications for a more inclusive family science
Authors: Gupta Shivangi , Tarantino Mari , Sanner Caroline 
Published: November 2023

AbstractPolyamory and consensual non‐monogamy (CNM) refer to partnerships in which individuals have romantic, emotional, and/or sexual relationships with multiple people, with the knowledge and consent of everyone involved. Recent decades have seen a surge in research interest in polyamory and CNM, warranting efforts to pause and take stock of empirical findings. In this scoping review, we evaluate and synthesize 209 research studies about polyamory and CNM, paying particular attention to trends in research design, theoretical application, and substantive findings. Researchers have focused broadly on (a) outcomes of CNM relationships, (b) attitudes and perceptions of CNM, (c) antecedents of CNM, (d) CNM relational processes, (e) CNM identity development, (f) polyamorous family and parenting, and (g) CNM politics and discourse. We synthesize research findings within each domain, identify gaps in the literature, and discuss the challenges and opportunities we see in advancing research on polyamory and CNM.
Child characteristics associated with child quality of life and parenting stress in Angelman syndrome
Authors: Hagenaar D. A. , Bindels‐de Heus K. G. C. B. , Lubbers K. , ten Hoopen L. W. , Rietman A. B. , de Nijs P. F. A. , Hillegers M. H. J. , Moll H. A. , de Wit M. C. Y. , Dieleman G. C. , Mous S. E. 
Published: November 2023

AbstractBackgroundAngelman syndrome (AS) is a rare neurodevelopmental disorder characterised by severe intellectual disability, movement disorder, epilepsy, sleeping problems, and behavioural issues. Little is known on child health‐related quality of life (HRQoL) in AS. AS family studies have reported elevated parenting stress and a high impact of the child's syndrome on the parent. It is unclear which factors influence child HRQoL and parenting stress/impact in AS.MethodsWe collected data prospectively through standardised clinical assessments of children with AS at the ENCORE Expertise centre for Angelman Syndrome at the Erasmus MC Sophia Children's Hospital. A linear regression analysis was conducted for the following outcome variables: (1) child HRQoL (Infant and Toddler Quality of Life Questionnaire); (2) the impact of the child's syndrome on the parent (Infant and Toddler Quality of Life Questionnaire); and (3) parenting stress (Parenting Stress Index). Predictor variables were child genotype, epilepsy, sleeping problems (Sleep Disturbance Scale for Children), cognitive developmental level (Bayley Cognition Scale), autistic features (Autism Diagnostic Observation Schedule) and emotional/behavioural problems (Child Behaviour Checklist). Covariates were sex, age and socio‐economic status.ResultsThe study sample consisted of 73 children with AS, mean age = 9.1 years, range = 2–18 years. Emotional/behavioural problems were the strongest significant predictor of lowered child HRQoL. Internalising problems were driving this effect. In addition, having the deletion genotype and higher age was related to lower child HRQoL. Sleeping problems were related to a higher impact of the child's syndrome on the parent. Finally, emotional/behavioural problems were associated with higher parenting stress. Cognitive developmental level, autistic features and epilepsy were not a significant predictor of child HRQoL and parenting stress/impact.ConclusionsThese results suggest that interventions aimed at increasing child HRQoL and decreasing parenting stress/impact in AS should focus on child emotional/behavioural problems and sleeping problems, using a family‐centred approach.
Communities make communities: Comunidades nativas and gold mining among the Arakbut of Peruvian Amazonia
Authors: Pinedo Danny 
Published: November 2023

AbstractThis article examines the role of organization into comunidades nativas (native communities) in the construction of a sense of community among Arakbut settlements of southeastern Peruvian Amazon. Based on ethnographic material, the article argues that communal activities furthered by the comunidad nativa increases social interaction among the settlements’ loosely connected and relatively dispersed kin‐based groups, forging a sense of belonging on which a broader collective identity and social bonds are built. Leasing Arakbut lands to mining settlers, however, has become a main source of internal conflict that threatens to split settlements. But rather than leading to settlement fissioning, this internal conflict encourages the Arakbut to use communal assemblies and fiestas to restore social relations and solidarity, thus strengthening the community identity. Therefore, the sense of community arises not only out of cooperative and cohesive social relations, but also out of conflictive and competitive ones.
An Integrative Review of Adverse Childhood Experiences and Reproductive Traumas of Infertility and Pregnancy Loss
Authors: Swift Alison , Berry Madison , Fernandez‐Pineda Madeline , Haberstroh Amanda 
Published: November 2023

IntroductionAdverse childhood experiences (ACEs) can lead to chronic diseases and mental health conditions; however, less is known about the associations of ACEs to the reproductive traumas of infertility and pregnancy loss. The purpose of this integrative review was to explore relationships between ACEs and the reproductive traumas of infertility and pregnancy loss.MethodsWe searched PubMed, SocINDEX, PsycINFO, and CINAHL databases in December 2021 and 2022. Inclusion criteria were qualitative or quantitative research, systematic or integrative reviews, or meta‐analysis articles in English that were peer‐reviewed and full‐text, addressing any ACE from the ACE Checklist and infertility or pregnancy loss. A total of 20 articles were included in the review. We used Whittemore and Knafl's integrative review framework, Preferred Reporting Items for Systematic Reviews and Meta‐analyses for reporting, and Covidence software for data management. A quality appraisal using Joanna Briggs Institute critical appraisal tools was performed. Relevant data were extracted into a matrix for iterative comparison.ResultsTwenty studies were included in the review. Results support there may be an association between pregnancy loss and infertility in women with a history of ACE, although results are mixed between infertility and ACEs. We also identified other concepts related to ACEs and the reproductive traumas of infertility and pregnancy loss and include racial and ethnically diverse populations, social determinants of health, modifiable risk factors, and stress appraisals.DiscussionMidwives and other women's health care providers should be aware that ACEs may be associated with pregnancy loss and infertility, although additional research is needed to further explore the relationships with infertility, mental health, and hypothalamic‐pituitary‐adrenal axis dysregulation from allostatic load. Trauma‐informed care and the development of effective interventions are warranted for women who experience ACEs. Providers should consider earlier interventions, including emotional services, for women with a history of ACE or reproductive trauma.
Serum 25 hydroxyvitamin D in non‐scarring alopecia: A systematic review and meta‐analysis
Authors: Chen Yuling , Dong Xin , Wang Yixin , Li Yu , Xiong Lidan , Li Li 
Published: November 2023

AbstractIntroductionNon‐scarring alopecia mainly includes androgenetic alopecia (AGA), female pattern hair loss (FPHL), alopecia areata (AA), telogen effluvium (TE), anagen effluvium (AE) and so on. Many studies had investigated the serum 25‐hydroxyvitamin D level and vitamin D deficiency of patients with these diseases, but opinions varied, and no conclusion was reached.MethodsRelevant articles were retrieved through PubMed, Web of Science, EMBASE, Cochrane Library, China National Knowledge Infrastructure (CNKI) and other databases. Serum 25‐hydroxyvitamin D [25(OH) D] levels and vitamin D deficiency were used as our primary outcome. The odds ratio (OR) and the standardized mean difference (SMD) with 95% confidence interval were both examined for vitamin D deficiency and levels.ResultsOur meta‐analysis had included a total of 3374 non‐scarring alopecia patients and 7296 healthy controls from 23 studies through the inclusion criteria and exclusion criteria. We found non‐scarring alopecia had decreased serum 25(OH)D level (WMD −7.29; 95% CI −9.21, −5.38) and increased vitamin D deficiency incidence (OR 3.11 95% CI 2.29, 4.22), compared with healthy controls. This meta‐analysis chose to conduct random‐effect model and subgroup analysis, because of the high heterogeneity (serum 25(OH)D level: I2 = 95%, vitamin D deficiency: I2 = 0%).ConclusionPatients with non‐scarring alopecia (including AA, FPHL, AGA and TE) have insufficient serum level of 25(OH)D and increased incidence of vitamin D deficiency. Vitamin D supplementation and monitoring for vitamin D deficiency may be helpful in treating non‐scarring alopecia.