bluuebunny/crossref_metadata_2025_split huggingface dataset:
The Development of Narrative Macrostructure of Thai Children
Authors: Rungrojsuwan Sorabud 
Published: October 2023

The present article aims to examine the development of storytelling ability of Thai children. The Thai Frog Story corpus, consisting of a total of 50 narratives by 4-, 6-, 9-, 11- and 20-year-old participants, is used as data for this study. Three main components of narrative macrostructure are employed as the framework for analysis: onset, problem and resolution. Results find that elementary children have shown significant acquisition of narrative macrostructure since the age of 9. In relation to percentage of acquisition, it is found that ‘problem’ is the easiest component to be recognized, followed by ‘onset’ and ‘resolution, respectively. More specifically, it is found that 4- to 6-year-old children tend to rely on immediate contexts and existing components in particular pictures. Accordingly, they fail to recognize the relationship among the protagonists and settings of the story. Moreover, they cannot keep the main plot along continuously until the end.
Teachers’ Attitudes towards the Use of a Web-Based Online Practice during a Fundamental English Language Course for Undergraduate Students
Authors: Moolkam Wannakorn , Boonmoh Atipat 
Published: October 2023

This research investigates teachers’ attitudes towards the use of a web-based online practice. During a fundamental English language course, Smart Choice Online Practice, a Virtual Learning Environment (VLE) from Smart Choice 3rd Edition coursebook, published by Oxford University Press, was presented to undergraduate students to assess students after learning LNG 101 from the usual classroom. In-depth interviews were conducted with ten English teachers at King Mongkut’s University of Technology Thonburi (KUMTT) to explore teachers’ attitudes after 13 weeks of the features of Smart Choice Online Practice from the teaching practice, focusing on the functions and the attitudes towards the use of Smart Choice Online Practice, including the advantages and disadvantages of using the Smart Choice online practice, and the teachers’ attitudes of using the Smart Choice Online Practice. The findings revealed Teachers’ positive attitudes towards the use of the Smart Choice online practice and prolong the use of Smart Choice Online Practice for the future course.
Underprivileged Students’ Second Language Motivation: Cases of Three Highly-Motivated Non-English Major Students
Authors: Nattheeraphong Anyarat 
Published: October 2023

This article presents the main qualitative findings from a mixed-methods study which applied Zoltán Dörnyei’s L2 Motivational Self System to explore the L2 motivation of 291 non-English major students in a regional university in Thailand. This article focuses on exploring three highlymotivated underprivileged students’ English motivation to gain insights into the extent to which the students’ possible L2-related selves and L2 learning experiences influence their L2 motivation. Also explored were the participants’ significant others’ perspectives on the participants’ English learning in order to gain a more holistic picture of the phenomena under study and to ensure data triangulation. Data were collected using a range of methods including semi-structured interviews and Snake interviews with the three main participants. Unstructured interviews were conducted with the main participants’ significant others. The interview transcripts were analyzed using content analysis. The findings revealed that there was a balance between the hope-for and feared selves, enabling the participants’ possible selves to motivate them in their English learning. The results also showed that the students’ L2 learning experience provided an immediate learning environment which fostered their development and motivated them in their English learning. These findings yielded important insights into how students’ L2-related selves play a crucial role in motivating them in their L2 learning as well as how policy planners, educators, administrators, teachers and parents can help create an environment which promotes L2 learning and motivation in their respective contexts.
A Needs Analysis of Thai Massage Employees’ (Thai Massage Therapists, Receptionists, and Managers) English Communication Skills in the city of Pattaya, Chonburi
Authors: Chiablaem Parichat 
Published: October 2023

English communication has gained its importance for Thai massage employees who are required to interact and provide massage services to foreign customers due to the popularity of Thai massage among foreigners. This study attempts to explore and analyze the needs and problems of Thai massage employees towards English communication in their workplaces located in Pattaya City, Thailand. This is a mixedmethodology research collecting data from 132 Thai massage employees through an online questionnaire and semi-structured interviews with five Thai massage employees to obtain insight data and further information. The key findings show that speaking and listening skills are the most needed skills including English vocabulary knowledge. In terms of themost problematic skills, speaking, listening, and writing respectively were rated as high while reading skill reported as moderate. According to the interview, the results reveal that English competency may not greatly affect the quality of Thai massage service; however, being able to use English properly increases customers’ satisfaction and reduces time for the employees to communicate with foreign customers. The findings also indicate that the Thai massage therapists use their body languages, pictures, and memorized English patterns and sample phrases to communicate with foreign customers as their solutions for Englishcommunication problems. This research which was conducted under a fund of the Faculty of Management Sciences, Kasetsart University reports the needs and problems of these groups of people in order to design an English for Spa course based on English for Specific Purposes (ESP) principles to foster English communication skills for the Thai massage employees as well as for business students who are interested in ESP courses.
A pilot study: effect of irisin on trabecular bone in a streptozotocin-induced animal model of type 1 diabetic osteopathy utilizing a micro-CT
Authors: Mohsin Sahar , Brock Fiona , Kaimala Suneesh , Greenwood Charlene , Sulaiman Mohsin , Rogers Keith , Adeghate Ernest 
Published: October 2023

Background
Osteoporosis is a significant co-morbidity of type 1 diabetes mellitus (DM1) leading to increased fracture risk. Exercise-induced hormone ‘irisin’ in low dosage has been shown to have a beneficial effect on bone metabolism by increasing osteoblast differentiation and reducing osteoclast maturation, and inhibiting apoptosis and inflammation. We investigated the role of irisin in treating diabetic osteopathy by observing its effect on trabecular bone.

Methods
DM1 was induced by intraperitoneal injection of streptozotocin 60 mg/kg body weight. Irisin in low dosage (5 µg twice a week for 6 weeks I/P) was injected into half of the control and 4-week diabetic male Wistar rats. Animals were sacrificed six months after induction of diabetes. The trabecular bone in the femoral head and neck was analyzed using a micro-CT technique. Bone turnover markers were measured using ELISA, Western blot, and RT-PCR techniques.

Results
It was found that DM1 deteriorates the trabecular bone microstructure by increasing trabecular separation (Tb-Sp) and decreasing trabecular thickness (Tb-Th), bone volume fraction (BV/TV), and bone mineral density (BMD). Irisin treatment positively affects bone quality by increasing trabecular number p < 0.05 and improves the BMD, Tb-Sp, and BV/TV by 21–28%. The deterioration in bone microarchitecture is mainly attributed to decreased bone formation observed as low osteocalcin and high sclerostin levels in diabetic bone samples p < 0.001. The irisin treatment significantly suppressed the serum and bone sclerostin levels p < 0.001, increased the serum CTX1 levels p < 0.05, and also showed non-significant improvement in osteocalcin levels.

Conclusions
This is the first pilot study to our knowledge that shows that a low dose of irisin marginally improves the trabecular bone in DM1 and is an effective peptide in reducing sclerostin levels.
Orthostatic Hypotension, Hypertension Treatment, and Cardiovascular Disease
Authors: Juraschek Stephen P. , Hu Jiun-Ruey , Cluett Jennifer L. , Ishak Anthony M. , Mita Carol , Lipsitz Lewis A. , Appel Lawrence J. , Beckett Nigel S. , Coleman Ruth L. , Cushman William C. , Davis Barry R. , Grandits Greg , Holman Rury R. , Miller Edgar R. , Peters Ruth , Staessen Jan A. , Taylor Addison A. , Thijs Lutgarde , Wright Jackson T. , Mukamal Kenneth J. 
Published: October 2023

ImportanceThere are ongoing concerns about the benefits of intensive vs standard blood pressure (BP) treatment among adults with orthostatic hypotension or standing hypotension.ObjectiveTo determine the effect of a lower BP treatment goal or active therapy vs a standard BP treatment goal or placebo on cardiovascular disease (CVD) or all-cause mortality in strata of baseline orthostatic hypotension or baseline standing hypotension.Data SourcesIndividual participant data meta-analysis based on a systematic review of MEDLINE, EMBASE, and CENTRAL databases through May 13, 2022.Study SelectionRandomized trials of BP pharmacologic treatment (more intensive BP goal or active agent) with orthostatic hypotension assessments.Data Extraction and SynthesisIndividual participant data meta-analysis extracted following PRISMA guidelines. Effects were determined using Cox proportional hazard models using a single-stage approach.Main Outcomes and MeasuresMain outcomes were CVD or all-cause mortality. Orthostatic hypotension was defined as a decrease in systolic BP of at least 20 mm Hg and/or diastolic BP of at least 10 mm Hg after changing position from sitting to standing. Standing hypotension was defined as a standing systolic BP of 110 mm Hg or less or standing diastolic BP of 60 mm Hg or less.ResultsThe 9 trials included 29 235 participants followed up for a median of 4 years (mean age, 69.0 [SD, 10.9] years; 48% women). There were 9% with orthostatic hypotension and 5% with standing hypotension at baseline. More intensive BP treatment or active therapy lowered risk of CVD or all-cause mortality among those without baseline orthostatic hypotension (hazard ratio [HR], 0.81; 95% CI, 0.76-0.86) similarly to those with baseline orthostatic hypotension (HR, 0.83; 95% CI, 0.70-1.00; P = .68 for interaction of treatment with baseline orthostatic hypotension). More intensive BP treatment or active therapy lowered risk of CVD or all-cause mortality among those without baseline standing hypotension (HR, 0.80; 95% CI, 0.75-0.85), and nonsignificantly among those with baseline standing hypotension (HR, 0.94; 95% CI, 0.75-1.18). Effects did not differ by baseline standing hypotension (P = .16 for interaction of treatment with baseline standing hypotension).Conclusions and RelevanceIn this population of hypertension trial participants, intensive therapy reduced risk of CVD or all-cause mortality regardless of orthostatic hypotension without evidence for different effects among those with standing hypotension.
Hemodynamic Reactivity to Mental Stress in Patients With Coronary Artery Disease
Authors: Moazzami Kasra , Cheung Brian , Sullivan Samaah , Shah Anish , Almuwaqqat Zakaria , Alkhoder Ayman , Mehta Puja K. , Pearce Brad D. , Shah Amit J. , Martini Afif , Obideen Malik , Nye Jonathon , Bremner J. Douglas , Vaccarino Viola , Quyyumi Arshed A. 
Published: October 2023

ImportanceThe clinical significance of hemodynamic reactivity to mental stress in the population with coronary artery disease (CAD) is unclear.ObjectiveTo investigate the association between hemodynamic reactivity to mental stress and the risk of adverse cardiovascular events in patients with stable CAD.Design, Setting, and ParticipantsThis cohort study included individuals with stable CAD from 2 prospective studies from a university-based hospital network: the Mental Stress Ischemia Prognosis Study (MIPS) and the Myocardial Infarction and Mental Stress Study 2 (MIMS2). Participants were enrolled between June 2011 and March 2016 and followed up for a median of 6.0 (IQR, 5.6-6.0) years in MIPS and 4.6 (IQR, 3.8-5.3) years in MIMS2. Data were analyzed from December 1, 2022, to February 15, 2023.ExposuresThe rate-pressure product (RPP) was calculated as the mean systolic blood pressure times the mean heart rate at rest. Rate-pressure product reactivity was calculated as the maximum RPP during a standardized mental stress test minus the RPP at rest.Main Outcomes and MeasuresThe primary outcome was a composite of cardiovascular death or nonfatal myocardial infarction. The secondary end point additionally included hospitalizations for heart failure.ResultsFrom the total of 938 individuals from the pooled cohort (mean [SD] age, 60.2 [10.1] years; 611 [65.1%] men), 631 participated in MIPS and 307 in MIMS2. A total of 373 individuals (39.8%) were Black, 519 (55.3%) were White, and 46 (4.9%) were of unknown race or ethnicity. The RPP increased by a mean (SD) of 77.1% (23.1%) during mental stress (mean [SD] absolute change, 5651 [2878]). For every SD decrease in RPP reactivity with mental stress, the adjusted hazard ratios for the primary and secondary end points were 1.30 (95% CI, 1.04-1.72) and 1.30 (95% CI, 1.06-1.56), respectively, in MIPS and 1.41 (95% CI, 1.06-1.97) and 1.21 (95% CI, 1.02-1.60), respectively, in MIMS2. In the pooled sample, when RPP reactivity to mental stress was added to a model including traditional clinical risk characteristics, model discrimination for adverse events improved (increase in C statistic of 5% for the primary end point; P = .009).Conclusions and RelevanceIn this cohort study of individuals with stable CAD, a blunted cardiovascular reactivity to mental stress was associated with adverse outcomes. Future studies are needed to assess the clinical utility of mental stress reactivity testing in this population.
Shaping Tomorrow's Liver Organoids: A Journey Toward Integrating Bile Ducts
Authors: Rizwan Muhammad 
Published: October 2023

AbstractLiver tissue engineering has undergone remarkable developments since the late 20th century, transitioning from simple two‐dimensional cultures to sophisticated three‐dimensional organoid models for drug toxicity assessments. Stem cell innovations have enabled the creation of liver organoids for disease modelling and tissue engineering. However, a key limitation is the absence of functional bile ducts in these organoids, crucial for replicating bile‐duct related diseases. Bile, synthesized by hepatocytes, plays a vital role in digesting fats and expelling lipid‐soluble wastes, including drug byproducts. Diseases impeding bile flow are responsible for many liver transplants and can cause severe conditions such as liver cirrhosis, causing over 50,000 annual deaths in the US. Current liver organoids, while bile‐producing, are devoid of bile ducts, limiting their efficacy in mimicking diseases related to bile flow. This article underscores the pressing need to incorporate bile ducts in engineered liver tissues, delves into the challenges faced in this effort, and highlights potential solutions through biomaterial and bioengineering techniques. Such advancements will offer researchers enhanced insights into bile duct disorders and pave the way for exploring innovative therapeutic strategies.
Platelet Membrane‐Enclosed Bioorthogonal Catalysis for Combating Dental Caries
Authors: Karmacharya Mamata , Kumar Sumit , Choi Yoon Jeong , Cho Yoon‐Kyoung 
Published: October 2023

AbstractPlatelets have shown promise as a means to combat bacterial infections, fostering the development of innovative therapeutic approaches. However, several challenges persist, including cargo loading issues, limited efficacy against biofilms, and concerns regarding the impact of payloads on the platelet carriers. Here, human platelet membrane vesicles (h‐PMVs) encapsulating supramolecular metal catalysts (SMCs) as “nanofactories” to convert prodrugs into antimicrobial compounds within close proximity to bacteria are introduced. Having established the feasibility and effectiveness of the SMCs withinh‐PMVs, referred to as the PLT‐reactor, to activate pro‐antibiotic drugs (pro‐ciprofloxacin and pro‐moxifloxacin) using model organisms (Escherichia coliATCC 25922 andStaphylococcus aureusATCC 25923), the investigation is subsequently extended to oral biofilms, with a particular emphasis onStreptococcus mutans3065. This “bind and kill” strategy demonstrates the potent antimicrobial specificity of the PLT‐reactor through localized antibiotic production.h‐PMVs play a pivotal role by enabling precise targeting of pathogenic biofilms on natural teeth while minimizing potential hemolytic effects. The finding indicates that platelet membrane‐cloaked surfaces exhibit robust, multifaceted, and pathogen‐specific binding affinity with excellent biocompatibility, making them a promising alternative to antibody‐based therapies for infectious diseases.
Catalyzing Viologen Electrochromic Reaction with CuOx Nanoparticles
Authors: Wu Liangliang , Fang Huajing , Li Jiaqi , Wu Lingqi , Wang Hong 
Published: October 2023

AbstractViologen‐based electrochromic devices have attracted great attention because of their tremendous potential in building energy conservation and low power display. However, the unsatisfactory performance at lower voltage limits their application, while the high driving voltage increases the energy consumption as well as safety risk. Herein, an electrocatalytic strategy is proposed for high‐performance viologen‐based electrochromic devices. Copper oxide (CuOx) nanoparticles are uniformly deposited on the F‐doped Tin Oxide (FTO) glass for enhancing the catalytic activity of Br−/Br3− redox couple, thereby promoting the interfacial charge transfer. The driving voltage can be reduced by ≈30% without sacrificing its high transparency (up to 80%) and the cycling stability can be significantly improved within 200 cycles. Large‐area smart windows and electrochromic displays are fabricated, which can be driven by the 1.5 V dry battery. This work opens up a new path to optimize the electrochromic performance of viologens and also lays the foundation for the application of catalysis in optoelectronic devices.
Closed‐Loop Recyclable Silica‐Based Nanocomposites with Multifunctional Properties and Versatile Processability
Authors: Hou Yi , Zhu Guangda , Catt Samantha O. , Yin Yuhan , Xu Jian , Blasco Eva , Zhao Ning 
Published: October 2023

AbstractMost plastics originate from limited petroleum reserves and cannot be effectively recycled at the end of their life cycle, making them a significant threat to the environment and human health. Closed‐loop chemical recycling, by depolymerizing plastics into monomers that can be repolymerized, offers a promising solution for recycling otherwise wasted plastics. However, most current chemically recyclable polymers may only be prepared at the gram scale, and their depolymerization typically requires harsh conditions and high energy consumption. Herein, it reports less petroleum‐dependent closed‐loop recyclable silica‐based nanocomposites that can be prepared on a large scale and have a fully reversible polymerization/depolymerization capability at room temperature, based on catalysis of free aminopropyl groups with the assistance of diethylamine or ethylenediamine. The nanocomposites show glass‐like hardness yet plastic‐like light weight and toughness, exhibiting the highest specific mechanical strength superior even to common materials such as poly(methyl methacrylate), glass, and ZrO2 ceramic, as well as demonstrating multifunctionality such as anti‐fouling, low thermal conductivity, and flame retardancy. Meanwhile, these nanocomposites can be easily processed by various plastic‐like scalable manufacturing methods, such as compression molding and 3D printing. These nanocomposites are expected to provide an alternative to petroleum‐based plastics and contribute to a closed‐loop materials economy.
A Cell‐Penetrant Peptide Disrupting the Transcription Factor CP2c Complexes Induces Cancer‐Specific Synthetic Lethality
Authors: Son Seung Han , Kim Min Young , Choi Sungwoo , Kim Ji Sook , Lee Yong Sang , Lee Sangwon , Lee Yeon Ju , Lee Jin Youn , Lee Seol Eui , Lim Young Su , Ha Dae Hyun , Oh Eonju , Won Young‐Bin , Ji Chang‐Jun , Park Mi Ae , Kim Boram , Byun Kyu Tae , Chung Min Sung , Jeong Jaemin , Choi Dongho , Baek Eun Jung , Cho Eung‐Ho , Kim Sang‐Bum , Je A. Reum , Kweon Hee‐Seok , Park Hyun Sook , Park Dongsun , Bae June Sung , Jang Se Jin , Yun Chae‐Ok , Chae Ji Hyung , Lee Jin‐Won , Lee Su‐Jae , Kim Chan Gil , Kang Ho Chul , Uversky Vladimir N. , Kim Chul Geun 
Published: October 2023

AbstractDespite advances in precision oncology, cancer remains a global public health issue. In this report, proof‐of‐principle evidence is presented that a cell‐penetrable peptide (ACP52C) dissociates transcription factor CP2c complexes and induces apoptosis in most CP2c oncogene‐addicted cancer cells through transcription activity‐independent mechanisms. CP2cs dissociated from complexes directly interact with and degrade YY1, leading to apoptosis via the MDM2‐p53 pathway. The liberated CP2cs also inhibit TDP2, causing intrinsic genome‐wide DNA strand breaks and subsequent catastrophic DNA damage responses. These two mechanisms are independent of cancer driver mutations but are hindered by high MDM2 p60 expression. However, resistance to ACP52C mediated by MDM2 p60 can be sensitized by CASP2 inhibition. Additionally, derivatives of ACP52C conjugated with fatty acid alone or with a CASP2 inhibiting peptide show improved pharmacokinetics and reduced cancer burden, even in ACP52C‐resistant cancers. This study enhances the understanding of ACP52C‐induced cancer‐specific apoptosis induction and supports the use of ACP52C in anticancer drug development.
Barium Oxynitride Electride as Highly Enhanced Promotor for Ruthenium Catalyst in Ammonia Synthesis: Comparative Study with Barium Oxide
Authors: Li Jiang , Jiang Yihao , Zhang Zhujun , Tsuji Masatake , Miyazaki Masayoshi , Kitano Masaaki , Hosono Hideo 
Published: October 2023

AbstractBarium oxide is a conventional promoter for various transition‐metal (TM) catalysts in ammonia synthesis. Ba‐promoted Ru catalysts are widely used for ammonia synthesis under mild reaction conditions. However, the promotion mechanism, including the active factor, remains unclear. In this study, the excellent promotion effect of barium oxynitride is reported, which creates anionic electrons in the lattice, forming an electride (BaOxNy:e−z) with the same rocksalt structure as BaO. The BaOxNy:e−z enhances the ammonia synthesis activity of the supported Ru catalyst by 40–100 fold compared with the BaO promotor. This study reveals that a low‐work‐function electron formed in the BaO lattice plays a pivotal role in the electronic promotion effect in catalytic ammonia synthesis, suggesting that BaOxNy:e−z formed near the surface during the ammonia synthesis reaction is an active species for the promotion effect of conventional BaO.