bluuebunny/crossref_metadata_2025_split huggingface dataset:
Characterization of nickel levels considering seasonal and intra-individual variation using three biological matrices
Authors: Min Jae-Hee , Lee Seungho , Lim Hyoun-Ju , Kang Min-Kyung , Son Hyunjin , Kim Byoung-Gwon , Hong Young-Seoub 
Published: December 2023

AbstractNickel compounds are classified as group 1 carcinogens by the International Agency for Research on Cancer. However, only a few exposure assessment studies have been conducted on such compounds to date. In this study, we investigated the distribution of nickel in three biological types of samples (blood, serum, and urine) and its temporal variability through repeated measurements. From 2020 to 2021, blood and urine samples were collected for four times from 50 healthy participants. Nickel concentrations were determined using inductively coupled plasma mass spectrometry, and inter-individual correlation was calculated from linear mixed model. The overall geometric mean of nickel was 1.028 μg/L in blood, 0.687 μg/L in serum, and 1.464 μg/L in urine. Blood nickel was the highest in November (blood: 1.197 μg/L), and the geometric mean of nickel concentrations in the serum and urine were the highest in March (serum: 1.146 μg/L; urine: 1.893 μg/L). This matched seasonal trends for fine particulate matter concentrations from 2020 to 2021. Thus, seasonal effects significantly affect nickel levels in blood, serum, and urine. The inter-individual correlations were low as 0.081 for blood and 0.064 for urine. In addition, the correlation of nickel levels between each biological sample was low. It was also found that age, gender, commuting time, and different matrices affect concentrations. Blood and serum nickel levels were high in this study compared to other nationwide data, with urinary nickel ranking the second highest among the six countries examined. Therefore, biomonitoring study in the general population should be conducted, and finding a suitable matrix that can reflect nickel exposure to set exposure guideline levels is imperative.
An ex-vivo and in-vitro dynamic simulator for surgical and transcatheter mitral valve interventions
Authors: Karl Roger , Romano Gabriele , Marx Josephin , Eden Matthias , Schlegel Philipp , Stroh Lubov , Fischer Samantha , Hehl Maximilian , Kühle Reinald , Mohl Lukas , Karck Matthias , Frey Norbert , De Simone Raffaele , Engelhardt Sandy 
Published: December 2023

Abstract
Purpose
Minimally invasive mitral valve surgery (MIMVS) and transcatheter edge-to-edge repair (TEER) are complex procedures used to treat mitral valve (MV) pathologies, but with limited training opportunities available. To enable training, a realistic hemodynamic environment is needed. In this work we aimed to develop and validate a simulator that enables investigation of MV pathologies and their repair by MIMVS and TEER in a hemodynamic setting.

Methods
Different MVs were installed in the simulator, and pressure, flow, and transesophageal echocardiographic measurements were obtained. To confirm the simulator’s physiological range, we first installed a biological prosthetic, a mechanical prosthetic, and a competent excised porcine MV. Subsequently, we inserted two porcine MVs—one with induced chordae tendineae rupture and the other with a dilated annulus, along with a patient-specific silicone valve extracted from echocardiography with bi-leaflet prolapse. Finally, TEER and MIMVS procedures were conducted by experts to repair the MVs.

Results
Systolic pressures, cardiac outputs, and regurgitations volumes (RVol) with competent MVs were 119 ± 1 mmHg, 4.78 ± 0.16 l min−1, and 5 ± 3 ml respectively, and thus within the physiological range. In contrast, the pathological MVs displayed increased RVols. MIMVS and TEER resulted in a decrease in RVols and mitigated the severity of mitral regurgitation.

Conclusion
Ex-vivo modelling of MV pathologies and repair procedures using the described simulator realistically replicated physiological in-vivo conditions. Furthermore, we showed the feasibility of performing MIMVS and TEER at the simulator, also at patient-specific level, thus providing new clinical perspectives in terms of training modalities and personalized planning.
Leverage points for tackling unsustainable global value chains: market-based measures versus transformative alternatives
Authors: Santika Truly , Nelson Valerie , Flint Michael , MacEwen Melissa , Cerretelli Stefania , Brack Duncan 
Published: December 2023

AbstractTropical forests are rapidly disappearing due to the expansion of cash crops to meet demands from distant markets. Pressing concerns on deforestation impacts resulting from the global trade of tropical commodities have led some high-income countries’ governments to consider diverse regulatory and trade levers to tackle the problem. These include proposals for new supply chain due diligence legislation concerning imports of forest-risk products and the inclusion of environmental measures in trade deals. To contribute to this debate, we conducted a comprehensive analysis of existing data on global trade and consumption patterns of tropical commodities, attribution of commodity production to deforestation, trade agreements, and progress in the implementation of crop sustainability standards. We used global data on key tropical commodities of oil palm, cocoa, and coffee. Our study shows that high-income countries have the highest per capita consumption for the three commodities evaluated and that consumption rates have dramatically increased in the last two decades. We discuss a range of measures that can potentially be required to tackle deforestation in global supply chains, which are currently being considered by policymakers, before discussing the kinds of post-growth, convivial approaches that are often excluded by the framing. Given the inherent expansionary nature of global market dynamics, we show that market-based initiatives are inadequate to tackle continuing deforestation and socio-ecological degradation. More transformative solutions amplify commoning and post-growth approaches are required to lead to some uncoupling of trade and territorialising of economic activity to fit within planetary boundaries and allow for plural values.
First Detection of Cryptosporidium parvum in the Endemic Cyprus Mouflon (Ovis gmelini ophion)
Authors: Hasapis Kyriacos A. , Charalambidou Iris , Schou Chad , O’Dowd Phanis Catherine , Kazamia Stefanie , Kassinis Nicolaos , Hadjisterkotis Eleftherios , Karanis Panagiotis 
Published: December 2023

Abstract
Purpose
Cryptosporidium is an intestinal zoonotic protozoan parasite that infects domesticated and wild animals. There are no reports on the prevalence and molecular characterisation of Cryptosporidium in the endemic Cyprus mouflon. The mouflon is strictly protected by national and international legislation. Its main distribution is Paphos State Forest and surrounding areas, where it may share the same water sources as free-ranging domestic goats. Therefore, the present study aimed to determine the prevalence of Cryptosporidium spp. and genotypes in mouflon and free-ranging goats within the mouflon range.

Methods
Faecal samples of 70 mouflons and 34 free-ranging goats were screened for Cryptosporidium by PCR amplification and sequencing.

Results
Only one sample (1/70) belonging to a mouflon was PCR positive for Cryptosporidium. Based on sequencing of the 18S rRNA locus, this species was identified as Cryptosporidium parvum (C. parvum). No positive sample was detected in the free-ranging goats (0/34).

Conclusion
This is the first report on the molecular identification of this Cryptosporidium species in a Cyprus mouflon. The results indicate that the prevalence of Cryptosporidium in Cyprus mouflon is low.
Fundamental Solutions for the Laplace–Beltrami Operator Defined by the Conformal Hyperbolic Metric and Jacobi Polynomials
Authors: Eriksson Sirkka-Liisa , Orelma Heikki 
Published: December 2023

AbstractIn this paper we study fundamental solutions for the Laplace–Beltrami operator
$$\begin{aligned} \Delta _\alpha f=x_n^{\frac{\alpha }{n-2}}\Big (\Delta f-\frac{\alpha }{x_n}\frac{\partial f}{\partial x_n}\Big ), \end{aligned}$$

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α

f
=

x
n

α

n
-
2

(

Δ
f
-

α

x
n

∂
f

∂

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n

)

,

defined on smooth enough functions in $$\mathbb {R}_+^{n}=\{ (x_1,\ldots ,x_n)\in \mathbb {R}^{n}: x_n>0\}$$

R
+
n

=

{

(

x
1

,
…
,

x
n

)

∈

R

n

:

x
n

>
0
}

. We represent explicit formulas for the fundamental solutions. Moreover, we establish fundamental solutions using Jacobi polynomials when $$n=3,5,7,\ldots .$$

n
=
3
,
5
,
7
,
…
.
Exploring the Role of Locus Coeruleus in Alzheimer’s Disease: a Comprehensive Update on MRI Studies and Implications
Authors: Galgani Alessandro , Giorgi Filippo Sean 
Published: December 2023

Abstract
Purpose of Review
Performing a thorough review of magnetic resonance imaging (MRI) studies assessing locus coeruleus (LC) integrity in ageing and Alzheimer’s disease (AD), and contextualizing them with current preclinical and neuropathological literature.

Recent Findings
MRI successfully detected LC alterations in ageing and AD, identifying degenerative phenomena involving this nucleus even in the prodromal stages of the disorder. The degree of LC disruption was also associated with the severity of AD cortical pathology, cognitive and behavioral impairment, and the risk of clinical progression.

Summary
Locus coeruleus-MRI has proved to be a useful tool to assess the integrity of the central noradrenergic system in vivo in humans. It allowed to test in patients preclinical and experimental hypothesis, thus confirming the specific and marked involvement of the LC in AD and its key pathogenetic role. Locus coeruleus-MRI–related data might represent the theoretical basis on which to start developing noradrenergic drugs to target AD.
Loss-on-Drying Prediction for a Vibrated Fluidised Bed Dryer by Means of Mass and Energy Balances
Authors: Kiricenko Katharina , Hartmann Felix , Altmeyer Andreas , Kleinebudde Peter 
Published: December 2023

Abstract
Purpose
Continuous wet granulation and drying require an adequate process control strategy to ensure the product quality. The most important critical quality attributes of dried granules are the granule size distribution and moisture content. Process analytical technologies (PATs) are available for real-time monitoring of moisture content by, e.g., near-infrared spectroscopy (NIRS), which requires additional installation and complex multivariate validation. Thus, a mass and energy balance (MEB) was derived for a vibrated fluidised bed dryer, which is part of the QbCon® 1 intended for continuous wet granulation and drying.

Method
Process parameters that are frequently logged were used for the derivation of a MEB. The predicted MEB was compared with the measured loss-on-drying (LOD) for two different formulations.

Results
The model-derived data were in good agreement with the observed LOD, leading to RMSE values of 0.12–0.45.

Conclusion
The implemented MEB can predict the LOD over time and thus might be suitable as a soft sensor without the installation of additional sensors. The obtained energy flux gives insight into the heat transfer, and the derived energy balance might be used to determine the required energy under certain drying conditions.
Colitis induced by IL-17A-inhibitors
Authors: Grümme Lea , Dombret Sophia , Knösel Thomas , Skapenko Alla , Schulze-Koops Hendrik 
Published: December 2023

Abstract
Background
Interleukin (IL)-17A is essential for intestinal mucosal integrity, contributing to the prevention of detrimental immunity such as infectious colitis and inflammatory bowel disease (IBD). Indeed, neutralization of IL-17A has been abandoned as a therapeutic principle in IBD because of increased disease activity. However, it is controversial whether IL-17A inhibitors increase the risk of developing colitis in patients who do not have underlying IBD. Here, we present two cases of different forms of colitis that occurred during treatment with two IL-17A inhibitors, secukinumab and ixekizumab.

Case presentations
We report the case of a 35-year-old female with SAPHO (synovitis–acne–pustulosis–hyperostosis–osteitis) syndrome who was admitted due to severe colitis with bloody diarrhea, fever, abdominal pain and weight loss after receiving secukinumab for 3 months as well as the case of a 41-year-old male with psoriatic arthritis who presented himself to the outpatient clinic with bloody stools, abdominal pain and nausea 5 months after changing his therapy from secukinumab to ixekizumab. In both patients, treatment with IL-17A-inhibitors was stopped and tumor necrosis factor inhibitors were started. Both patients recovered, are clinically stable and show no more signs of active colitis.

Conclusion
The role of IL-17A inhibitors in the pathogenesis of infectious colitis and new-onset IBD is not fully understood and requires further research. Patients receiving IL-17A-inhibitor therapy should be carefully screened and notified of the possible side effects.
Fault stability analysis and its application in stress inversion quality assessment
Authors: Li Zhenyue , Wan Yongge , Liu Ruifeng , Guo Xiangyun , Sheng Shuzhong 
Published: December 2023

AbstractFault stability analysis plays an important role in assessing the potential hazard of faults and in studying the mechanism of earthquake occurrence. Fault stability depends on the magnitude of the normal and shear stresses imposed on the fault by the tectonic stress and rock friction, while the magnitude of the normal and shear stresses is related to the spatial orientation of the fault normal with respect to the three principal stress axes, so it is easier to understand the variation of fault stability with its orientation by expressing the stability of different faults in the principal axis coordinate system. In this paper, we first developed a method to plot the stability of faults with different orientations in the principal stress axis coordinate system, then investigated the influence of the magnitude of principal stresses and friction on fault instability, and reached the conclusion that the instability is mainly affected by the relative magnitude of principal stresses (shape ratio). Finally, we proposed to use fault stability as an indicator to evaluate the quality of inverted stress obtained from fault slip data or earthquake focal mechanisms, that is, to evaluate the reliability of the inverted stress according to the compatibility of stress and fault stability. It is described in detail in terms of measured fault slip data from two regions.
Psychometric Properties of the Polish Version of the Mindful Self-Care Scale-Standard
Authors: Larionow Paweł , Cook-Cottone Catherine , Pilarska Natalia 
Published: December 2023

Abstract
Objectives
The Mindful Self-Care Scale-Standard (MSCS-Standard) is a 33-item self-report questionnaire that assesses mindfulness practices in six self-care domains: (1) physical care, (2) mindful relaxation, (3) supportive structure, (4) supportive relationships, (5) mindful awareness, and (6) self-compassion and purpose. The study aimed to validate the Polish version of the MSCS-Standard.

Method
The study was performed on a sample of 774 people (646 females, 122 males, and 6 non-binary) aged 18–76 (M = 28.49, SD = 10.81). The factor structure was verified with confirmatory factor analysis. Convergent and divergent validity were assessed based on the relationship between the MSCS-Standard scores and markers of alexithymia, anxiety, depression, stress, and somatic symptoms as well as life satisfaction. We examined discriminant validity by conducting a second-order exploratory factor analysis of MSCS-Standard subscales, alexithymia traits, anxiety, depression, stress, and somatic symptoms.

Results
Our results indicated a good factorial validity, conforming to the intended 6-factor structure (χ2/df = 1352.38/477; CFI = 0.912; RMSEA = 0.051 [90% CI: 0.048; 0.055]; SRMR = 0.064). As expected, all MSCS-Standard subscales correlated in expected directions with markers of alexithymia, anxiety, depression, stress, and somatic symptoms as well as with life satisfaction. The MSCS-Standard showed a good discriminant validity in terms of measuring mindfulness practices construct that was separable from people’s current levels of alexithymia, negative affect and somatic symptoms. Internal consistency reliability was also good.

Conclusions
Overall, the Polish version of the MSCS-Standard appears to have satisfactory psychometric properties.

Preregistration
This study is not preregistered.
Evaluation of an automatic continuous high-lift system in a flight simulator study with airline pilots
Authors: Eichhorn Pia , Silvestre Flávio 
Published: December 2023

AbstractIn the INTELWI LuFo research project, TU Berlin is investigating an automatic, continuously operating high-lift system for passenger aircraft. Today’s commercial aircraft operate the high-lift systems in fixed steps. Typically, five fixed steps result from the different requirements for take-off and landing. For each flap position, there is a speed of best glide. Since aircraft decelerate during landing, they usually fly outside the optimum point. This is improved by a continuous flap system, as it continuously adjusts the flap position depending on the current flight condition. Flight simulation studies allow modelling and evaluation of new flight control functions at an early stage of development. This paper evaluates the flight simulator study for the assessment of the Automatic Continuous Moving Slat/Flap System with a focus on the pilots’ assessment. Ten airline pilots took part in the study in the SEPHIR flight simulator at TU Berlin. The approach scenarios vary with regard to the energy content of the approach since the high-lift system influences the energy management. The evaluation is based on questionnaires answered by the pilots after each approach. The participating pilots particularly emphasised the reduction of the workload and the pleasant integration of the continuous flap function into the existing cockpit procedures. According to the participating pilots, there is potential for improvement and further scenarios to investigate the functions behaviour in the event of failures in systems that affect flap operation.
C-reaktives Protein (CRP) – ein diagnostischer Entzündungsmarker am Beispiel ausgewählter Indikationen
Authors: Oremek GM , Holzgreve F , Wanke EM , Germann U , Ohlendorf Daniela 
Published: December 2023

ZusammenfassungIm Rahmen der Serie „Biomarker“, die im Zentralblatt für Arbeitsmedizin, Arbeitsschutz und Ergonomie publiziert wird, ist das CRP (C-reaktives Protein) zugehörig als häufiger Marker in der Diagnostik von akuten und chronischen Entzündungserkrankungen. Die Bestimmung von CRP stellt einen wesentlichen Bestandteil der Diagnostik von Infektionserkrankungen dar. Virale und bakterielle Infektionen können anhand der Konzentrationshöhe von CRP erkannt werden. CRP erwies sich als Marker mit einer hohen Sensitivität und Spezifität bei Infektionserkrankungen. Werden die unterschiedlichsten Aspekte der arbeitsmedizinischen Vorsorge betrachtet, so hat die CRP-Bestimmung im Bereich der Diagnostik der Infektionen ihre Berechtigung.
Thermal Infrared Remote Sensing of Stress Responses in Forest Environments: a Review of Developments, Challenges, and Opportunities
Authors: Smigaj Magdalena , Agarwal Avinash , Bartholomeus Harm , Decuyper Mathieu , Elsherif Ahmed , de Jonge Arjen , Kooistra Lammert 
Published: December 2023

Abstract
Purpose of Review
The successful application of thermal infrared (TIR) remote sensing in the agricultural domain, largely driven by the arrival of new platforms and sensors that substantially increased thermal data resolution and availability, has sparked interest in thermography as a tool for monitoring forest health. In this review, we take a step back to reflect on what physiological responses are reflected in leaf and canopy temperature and summarise research activities on TIR remote sensing of stress responses in forest environments, highlighting current methodological challenges, open questions, and promising opportunities.

Recent Findings
This systematic literature review showed that whilst the focus still remains on satellite imagery, Uncrewed Aerial Vehicles (UAVs) are playing an increasingly important role in testing the capabilities and sensitivity to stress onset at the individual tree level. To date, drought stress has been the focal point of research, largely due to its direct link to stomatal functioning at leaf level. Though, research into thermal responses to other stressors, e.g. pathogens, is also gaining momentum.

Summary
Disentangling stress-induced canopy temperature variations from environmental factors and structural influences remains the main challenge for broader application of TIR remote sensing. Further development and testing of approaches for thermal data analysis, including their applicability for different tree species and sensitivity under different climatic conditions, are required to establish how TIR remote sensing can best complement existing forest health monitoring approaches.
Bert-based graph unlinked embedding for sentiment analysis
Authors: Jin Youkai , Zhao Anping 
Published: December 2023

AbstractNumerous graph neural network (GNN) models have been used for sentiment analysis in recent years. Nevertheless, addressing the issue of over-smoothing in GNNs for node representation and finding more effective ways to learn both global and local information within the graph structure, while improving model efficiency for scalability to large text sentiment corpora, remains a challenge. To tackle these issues, we propose a novel Bert-based unlinked graph embedding (BUGE) model for sentiment analysis. Initially, the model constructs a comprehensive text sentiment heterogeneous graph that more effectively captures global co-occurrence information between words. Next, by using specific sampling strategies, it efficiently preserves both global and local information within the graph structure, enabling nodes to receive more feature information. During the representation learning process, BUGE relies solely on attention mechanisms, without using graph convolutions or aggregation operators, thus avoiding the over-smoothing problem associated with node aggregation. This enhances model training efficiency and reduces memory storage requirements. Extensive experimental results and evaluations demonstrate that the adopted Bert-based unlinked graph embedding method is highly effective for sentiment analysis, especially when applied to large text sentiment corpora.