bluuebunny/crossref_metadata_2025_split huggingface dataset:
Cortical structural differences following repeated ayahuasca use hold molecular signatures
Authors: Mallaroni Pablo , Mason Natasha L. , Kloft Lilian , Reckweg Johannes T. , van Oorsouw Kim , Ramaekers Johannes G. 
Published: October 2023

IntroductionSerotonergic psychedelics such as ayahuasca are reported to promote both structural and functional neural plasticity via partial 5-HT2A agonism. However, little is known about how these molecular mechanisms may extend to repeated psychedelic administration in humans, let alone neuroanatomy. While early evidence suggests localised changes to cortical thickness in long-term ayahuasca users, it is unknown how such findings may be reflected by large-scale anatomical brain networks comprising cytoarchitecturally complex regions.MethodsHere, we examined the relationship between cortical gene expression markers of psychedelic action and brain morphometric change following repeated ayahuasca usage, using high-field 7 Tesla neuroimaging data derived from 24 members of an ayahuasca-using church (Santo Daime) and case-matched controls.ResultsUsing a morphometric similarity network (MSN) analysis, repeated ayahuasca use was associated with a spatially distributed cortical patterning of both structural differentiation in sensorimotor areas and de-differentiation in transmodal areas. Cortical MSN remodelling was found to be spatially correlated with dysregulation of 5-HT2A gene expression as well as a broader set of genes encoding target receptors pertinent to ayahuasca’s effects. Furthermore, these associations were similarly interrelated with altered gene expression of specific transcriptional factors and immediate early genes previously identified in preclinical assays as relevant to psychedelic-induced neuroplasticity.ConclusionTaken together, these findings provide preliminary evidence that the molecular mechanisms of psychedelic action may scale up to a macroscale level of brain organisation in vivo. Closer attention to the role of cortical transcriptomics in structural-functional coupling may help account for the behavioural differences observed in experienced psychedelic users.
Comparison of three malnutrition screening tools prior to allogeneic hematopoietic stem-cell transplantation
Authors: Khosroshahi Reza Amiri , Mohammadi Hamed , Barkhordar Maryam , Zeraattalab-Motlagh Sheida , Imani Hossein , Rashidi Amirabbas , Sadeghi Erfan , Wilkins Simon , Mousavi Seyed Asadollah 
Published: October 2023

BackgroundPrevious studies have shown that malnutrition before hematopoietic stem cell transplantation (HSCT) is associated with poor patient prognoses. There is inconsistency among studies on which nutritional status screening tool is appropriate for malnutrition diagnosis before allo-HSCT. The present study aimed to compare nutritional screening tools in patients with leukemia before allo-HSCT.MethodsAn observational, cross-sectional, and single-center study was conducted in Tehran, Iran. One hundred four adults allo-HSCT candidates aged 18-55 years with leukemia were selected sequentially. Malnutrition assessment was done using three tools, the Global Leadership Initiative on Malnutrition (GLIM), nutritional risk screening 2002 (NRS-2002) and European Society for Clinical Nutrition and Metabolism (ESPEN) criteria. The agreement between malnutrition assessment tools was evaluated with Cohen’s kappa.ResultsThe agreement between GLIM and NRS-2002 was perfect (κ = 0.817, p &lt; 0.001), while the agreement between GLIM and ESPEN was fair (κ = 0.362, p &lt; 0.001). The agreement between NRS-2002 and ESPEN was fair (κ = 0.262, p &lt; 0.001). We also found a moderate agreement for all tools (κ = 0.489, p &lt; 0.001).ConclusionNRS-2002 is an accepted tool for screening malnutrition in hospitalized patients. In the current study, the GLIM criterion perfectly agreed with the NRS-2002. Further studies in the HSCT setting are needed to introduce a valid tool.
The role of nutritional risk evaluation in predicting adverse outcomes among patients with severe COVID-19 in Vietnam
Authors: Nguyen Lan Huong Thi , Dang Anh Kim , Tran Tien Viet , Phan Hai Thanh , Doan Dao Anh Thi , Nguyen Lien Bao Thi , Tran Anh Minh , Do Tung Dinh , Nguyen Thang Ba , Nguyen Tien Thanh , Nguyen Binh Huy , Le Huong Thi 
Published: October 2023

IntroductionAs sufficient nutrition helps alleviate catabolic stress and modulate the systemic inflammatory response of the body, it plays an indispensable role in the good prognosis of critically ill patients. Thus, this study aimed to investigate the malnutrition of patients with severe COVID-19 and its association with adverse treatment outcomes.MethodsWe conducted a retrospective cross-sectional study in two provincial hospitals in Hanoi from February to April 2022. Participants were patients with severe COVID-19 admitted to the Intensive Care Unit (ICU). Malnutrition risk were evaluated by Nutritional Risk Screening-2002 (NRS), Global Leadership Initiative on Malnutrition (GLIM), Prognostic Nutritional Index (PNI), and the adverse prognosis was assessed by Acute Physiology and Chronic Health Evaluation II (APACHE II). The multivariate receiver-operating characteristic (ROC) curve was applied to estimate the predictive ability of those criteria regarding worse treatment results.ResultsThe percentages of malnutrition measured by NRS, GLIM, PNI, and BMI were 62.6, 51.5, 42.9, and 16.6%, respectively. Patients with more severe malnutrition assessed by GLIM, PNI, and having above target fasting blood glucose (FBG) (≥10.0 mmol/L) were more likely to have higher APACHE scores. PNI had a better diagnostic performance than NRS and BMI (AUC = 0.84, 0.81, and 0.82, respectively). In addition, FBG revealed a good prognostic implication (AUC = 0.84).ConclusionA relatively high percentage of patients experienced moderate and severe malnutrition regardless of screening tools. Individuals at higher risk of malnutrition and high FBG were predicted to have more adverse treatment outcomes. It is recommended that nutritional screening should be conducted regularly, and personalizing nutritional care strategies is necessary to meet patients’ nutrient demands and prevent other nutrition-related complications.
Efficacy and acceptability of third-wave psychotherapies in the treatment of depression: a network meta-analysis of controlled trials
Authors: Schefft Cora , Heinitz Christian , Guhn Anne , Brakemeier Eva-Lotta , Sterzer Philipp , Köhler Stephan 
Published: October 2023

IntroductionIn recent decades, various new psychotherapy approaches have been developed in an effort to overcome issues of non-response, referred to as “third-wave psychotherapies.” How third-wave therapies perform in comparison to each other, to classical CBT, or other common comparators in the treatment of depression has not yet been systematically assessed.MethodsWe firstly determined the scope of the term “third-wave” by conducting a systematic search. The identified approaches were then used as search terms for the systematic review and network meta-analysis (NMA). We searched MEDLINE, CENTRAL, PsychINFO and Web of Science from inception until 31 July 2022. We assessed randomized controlled trials comparing third-wave psychotherapies to each other, CBT, treatment as usual (TAU), medication management, active control conditions, or waitlist (WL) in adult populations with depressive disorders. The treatments included were acceptance and commitment therapy, behavioral activation, cognitive behavioral analysis system of psychotherapy, dialectical behavioral therapy, mindfulness-based cognitive therapy, meta-cognitive therapy, positive psychotherapy and schema therapy. The primary outcome was depression severity (efficacy) at study endpoint, and the secondary outcome was all-cause discontinuation (acceptability). This review was registered in PROSPERO, identifier CRD42020147535.ResultsOf 7,971 search results, 55 trials were included in our NMA (5,827 patients). None of the third-wave therapies were more efficacious than CBT but most were superior to TAU [standardized mean differences (SMD) ranging between 0.42 (95% CI −0.37; 1.19) and 1.25 (0.48; 2.04)]. Meta-cognitive therapy (MCT) was more efficacious than three other third-wave therapy approaches. None of the third-wave treatments were more acceptable than WL or CBT. Twenty-seven percent of the trials were rated as low risk of bias. Confidence in the evidence was largely low according to GRADE. Inconsistency emerged for a small number of comparisons.InterpretationsThird-wave therapies are largely efficacious and acceptable alternatives to CBT when compared to TAU, with few differences between them. The evidence so far does not point toward superiority or inferiority over CBT. Patient-level research may offer possibilities for tailoring individual psychotherapies to the needs of individual patients and future trials should make this data available. The evidence base needs to be broadened by sufficiently powered trials.
Can adolescents' subjective wellbeing facilitate their pro-environmental consumption behaviors? Empirical study based on 15-year-old students
Authors: Zhang Min , Zhang Weidong , Shi Yong 
Published: October 2023

PurposeTo address the challenge of declining pro-environmental behaviors in adolescence, this paper uses the theoretical foundations for subjective wellbeing to verify the influence of three latent dimensions of subjective wellbeing (life satisfaction, positive emotions, and negative emotions) on adolescents' pro-environmental consumption behaviors (PECBs). Furthermore, we explore the moderating effects of nations and regions in the relationship between subjective wellbeing and PECBs in adolescents.MethodBased on the international data from the Programme for International Student Assessment 2018 (PISA 2018), we construct a unique dataset that includes 57,182 samples related to the subjective wellbeing and PECBs of 15-year-old students from eight countries/economies. Specially, we employ an ordered probit model to test our hypotheses.FindingsBoth adolescents' life satisfaction and positive emotions can significantly improve their PECBs, while there is a significant negative association between negative emotions and PECBs. At the nation's level, adolescents' life satisfaction and negative emotions in developed countries/economies significantly impact PECBs. In contrast, the positive emotions of adolescents in developing countries/economies have more substantial effects on PECBs. At the regional level, the impact of all three dimensions of adolescents' subjective wellbeing on PECBs is more significant in rural than urban areas.Originality/valueThis paper provides a new perspective for understanding adolescents' PECBs from the insights of subjective wellbeing. Previous studies have examined the effects of life satisfaction or happiness on PECBs in adults. This paper examines the impact of subjective wellbeing on adolescents' PECBs from life satisfaction, positive emotions, and negative emotions, which suggests that promoting adolescents' subjective wellbeing can be an effective strategy for encouraging PECBs. From a comparative research perspective, we further analyze the differences between the nations at different levels of development, the rural and urban areas, providing a valuable reference for policymakers and practitioners in promoting pro-environmental behaviors among adolescents.
Prevalence of post-traumatic stress disorder among residents of Shanghai standardized training programs during the COVID-19 outbreak: a cross-sectional study
Authors: Huang Ruiwen , Tang Chao , Luo Jianfeng , Li Tingting , Wang Li , Li Chang , Cao Lu , Wu Shiyu 
Published: October 2023

BackgroundThe COVID-19 pandemic may have increased the prevalence of psychiatric disorders, such as anxiety, depressive disorders, and post-traumatic stress disorder (PTSD), among healthcare workers.PurposeThis study aims to investigate the prevalence of PTSD and its risk factors among residents in the standardized residency training programs (SRTPs) in Shanghai during the COVID-19 outbreak.Participants and methodsAn online cross-sectional survey was conducted between December 17, 2021, and January 7, 2022, among SRPT residents from 15 hospitals in Shanghai, China. Questionnaires comprising general information, medical-related traumatic event experiences, the PTSD Checklist (PCL-5), and the perceived social support scale (PSSS) were distributed to the participants using the online Questionnaire Star electronic system.ResultsWe included 835 valid responses for the analysis. In total, 654 residents (78.3%) had experienced at least one traumatic event, and 278 residents (33.3%) were found to have PTSD symptoms. The age 26–30 years old, female sex, and increased resident working hours were identified as the risk factors for PTSD (p &lt; 0.05), and perceived social support had a significant negative association with PTSD (p &lt; 0.05).ConclusionDuring the COVID-19 pandemic, there was a high prevalence of PTSD among SRTPs residents in Shanghai. The age 26–30 years old, female sex, and increased resident working hours were identified as risk factors for PTSD, while perceived social support was identified as a protective factor against PTSD. The present findings can be applied in STRPs management and provide useful information for designing special interventions and protocols for SRTPs residents.
Expectations of employers in the United States for entry-level public health job skills with a bachelor’s degree: an analysis of the positions advertised in an online job portal
Authors: Kedia Satish K. , Entwistle Coree , Lee Guijin , Magaña Laura , Burke Emily M. , Joshi Ashish 
Published: October 2023

ObjectivesTo analyze the current public health labor market for bachelor’s-level graduates.MethodsPublic health-related job postings (N = 365) from across the United States were collected from an online job portal, Indeed.com, from November 7–14, 2022. Job titles, organization type, degree requirements, work experience, job location, and preferred skills for bachelor’s-level public health positions were analyzed.ResultsThirty-one job titles were identified. Approximately one-third (32.33%) of postings were from the Northeastern US; 23.56% were from the Southeastern region. Thirty-five job skill categories were identified. Most jobs (92.33%) required oral and written communication skills, and 85.21% specified educational skills for public health promotion. Cultural competency, project management, and case management abilities were also highly sought.ConclusionThis study revealed the needs of the public health workforce and bolstered the case that public health degree-seekers should be equipped with a set of strategic skills applicable to a range of multisectoral and multidisciplinary public health jobs.Policy implicationsGiven the rapid changes in the field of public health, ongoing analysis of the labor market benefits educators, employers, and policymakers alike.
Body image construction and mental health levels among college students: a data survey of Chinese university students
Authors: Wang Xing , Lu Chuntian , Niu Long 
Published: October 2023

BackgroundWith the rapid changes in body image construction brought about by the upgrading of consumption in China, trend-seeking college students are faced with mental health problems brought about by the pursuit of the “ideal body type,” which cannot be ignored. This study aims to explore the relationship between body image construction and mental health among college students. This study utilized data from the Survey on Physical Activity and Mental Health of College Students. A total of 1,192 students were randomly selected as the survey sample, and 1,044 valid samples were obtained. The mean age of the respondents was 19.34 years.MethodsFirst, we categorized body image constructs into three categories based on the differences between subjective and objective body image: high acceptance, low acceptance, and consistency. Second, to ensure analytical rigor and minimize potential confounders, we used a generalized propensity score weighting model. Finally, we used a causal mediation framework to investigate the potential causal mechanisms between the independent variable (perceived body image bias) and the dependent variable (mental health) in order to better understand the “net effect.”Results(1) There is a significant correlation between college students’ body image perceptual bias and mental health, i.e., the higher the individual’s acceptance of his/her own body image, the higher the level of mental health, and vice versa. (2) Students in humanities and social sciences are more likely to have increased psychological burden due to poor negative body image. (3) In the mediation analysis, although the causal mediating effect of physical exercise was not significant, family and peer support in physical exercise played an important mediating role, especially the influence of peers was more significant.ConclusionThe construction of body image is a double-edged sword that can either promote positive individual development or lead to self-depreciation. Creating a positive climate for physical activity has a positive impact on college students’ mental health compared to participation in physical activity behaviors. While improving students’ media literacy on college campuses, it is important to enhance adaptive guidance to promote their physical and mental health and personal development.
A Framework for Migration of Microservices based Applications to Serverless Platform with Efficient Cold Start Latency
Authors: Raj Vinay 
Published: October 2023

<p>Serverless computing has become a very popular cloud-based solution for designing, testing and deploying the applications as serverless functions. Serverless computing has become a buzzword in both industry and academia as many large IT giants have rolled out their own serverless platforms. Independent design, deployment and auto scalability are its major features with Function-as-a-Service (FaaS) as its popular implementation. On the other hand, microservices are an emerging trend for design of large enterprise applications as many companies like Amazon, Uber and Spotify have already migrated their existing applications to microservices style. However, with the advent of serverless platforms, to design efficient applications with simpler infrastructure management, reduced operational overhead and cost factor, migrating microservices to serverless has become inevitable. Additionally, existing studies report that serverless platforms suffer from cold start latency. Therefore, in this paper, a framework is proposed which has two phases: (i) an empirical investigation to find out the impact of programming language on the cold start of serverless functions and (ii) an approach for migration of microservices to serverless platforms. The evaluation results help us to identify the platform with low cold start latency and also recommend the choice of programming language with lower latency. After migrating the containerized microservices to serverless, a comparison in terms of performance is conducted. The applications designed as serverless functions exhibit better response time and throughput compared to containerized microservices. </p>
Histiocytic Sarcoma Treated with Pembrolizumab: A Case Report and Literature Review
Authors: Huff Daniel , Fortin Ensign Shannon , Ryan Margaret S. , Palmer Jeanne , Munoz Javier 
Published: October 2023

ABSTRACT
Histiocytic sarcoma (HS) is a rare hematologic malignancy that has historically been treated with lymphoma-based regimens with a median survival of 6 months. We describe a case of a 51-year-old woman who presented with acute back pain and cord compression. She was diagnosed with HS with diffuse skeletal lesions and high expression of programmed death ligand 1 (PD-L1). She was subsequently treated with chemotherapy plus off-label use of pembrolizumab followed by allogeneic stem cell transplantation. Ultimately, the patient died in the setting of progression of disease 17 months after her stem cell transplantation and 26 months after her diagnosis. This article also presents a literature review of cases of HS treated with programmed death ligand inhibition.
Integración de competencias para el desarrollo disciplinar en la enseñanza del diseño gráfico: experiencia metodológica en el programa académico
Authors: Narvaez-Caballero Nikolai Alexander 
Published: October 2023

El presente artículo relata una estrategia metodológica implementada desde el aula de clase, como herramienta en el proceso de enseñanza-aprendizaje, que relaciona competencias para el desarrollo disciplinar semestre a semestre, y donde se hacen tangibles; diferentes propuestas proyectuales y su integración con sus propósitos de aprendizaje, la obtención de métodos y fundamentos apropiados en la implementación de un pensamiento creativo, reconocido por los participantes del Programa Académico de Diseño Gráfico. Por lo tanto, se retoman actividades desde el área transversal básica investigativa como columna estratégica en la recolección de información y la aprehensión de experiencias, basada en la práctica y la investigación, como herramientas y parámetros necesarios en la obtención de su ejercicio profesional y ocupacional. Un proceso implementado en la acción participativa de un proyecto educativo a través de sus núcleos básicos problémicos, para denotar el producto de conocimiento en el “Proyecto Integra Comunidad+diseño” o proyecto integrador, ciclo técnico profesional; en c de la Corporación Unificada Nacional de Educación Superior (CUN), Colombia.
Ileoileal Intussusception Secondary to Meckel's Diverticulum: A Case Report
Authors: Saing Sylvia Noviani , Eriska Geriana Permatasari Saing  
Published: October 2023

Background: The most frequently documented aetiology of Meckel's related obstructions is volvulus or intussusception of the small bowel with the presence of Meckel's diverticulum as the lead point. This study presents a case of small bowel obstruction caused by intussusception due to Meckel's diverticulum, which led to an obstruction of the small intestine.
Case presentation: A 17-year-old male patient visited the hospital's emergency room complaining of worsening abdomen pain for two days. It was associated with abdominal distention, fever, nausea, and vomiting. There was no roving's sign or psoas sign and no rebound tenderness. There is no history of gastrointestinal cancer in his family or previous abdominal surgery. The white blood cell count was 18,400 c/mm, and the electrolytes, liver function tests (LFTs), and urinalysis were all within normal ranges. Ultrasonography imaging of right lower quadrant (RLQ): thickening tubular structure with target sign view and enteric intussusception with the possibility of appendix component.
Conclusion: A 17-year-old male went to the emergency room complaining of acute abdominal pain and was diagnosed with ileoileal intussusception intraoperatively.