bluuebunny/crossref_metadata_2025_split huggingface dataset:
Enhanced Terahertz Spectroscopy of a Monolayer Transition Metal Dichalcogenide
Authors: Jin Xin , Aglieri Vincenzo , Jeong Young‐Gyun , Pezeshki Atiye , Skokan Lilian , Shagar Mostafa , Jia Yuechen , Bianucci Pablo , Ruediger Andreas , Orgiu Emanuele , Toma Andrea , Razzari Luca 
Published: January 2025

Abstract2D materials, including transition metal dichalcogenides, are attractive for a variety of applications in electronics as well as photonics and have recently been envisioned as an appealing platform for phonon polaritonics. However, their direct characterization in the terahertz spectral region, of interest for retrieving, e.g., their phonon response, represents a major challenge, due to the limited sensitivity of typical terahertz spectroscopic tools and the weak interaction of such long‐wavelength radiation with sub‐nanometer systems. In this work, by exploiting an ad‐hoc engineered metallic surface enabling a ten‐thousand‐fold local absorption boost, enhanced terahertz spectroscopy of a monolayer transition metal dichalcogenide (tungsten diselenide) is performed and its dipole‐active phonon resonance features are extracted. In addition, these data are used to obtain the monolayer effective permittivity around its phonon resonance. Via the direct terahertz characterization of the phonon response of such 2D systems, this method opens the path to the rational design of phonon polariton devices exploiting monolayer transition metal dichalcogenides.
The Optical Encoder Based on Mechanoluminescent Materials and Application in Dual‐Key Encryption
Authors: Liu Yun , Yu Junwen , Niu Quanwang , Wang Xiangfu 
Published: January 2025

AbstractOptical information encryption is an effective security strategy currently used to protect data and prevent information leakage. However, the optical information encryption technology based on mechanoluminescent (ML) materials faces challenges of the single encryption mode and the lack of systematic dual‐key decryption strategies. In this study, a three‐layer structure optical encoder is proposed using porous ML material as the luminescent layer, a quartz transparent tube with pressure‐sensing capabilities as the stress‐loading layer, and photodetector as the optical recognition layer. A dual‐key encryption system based on the evolution mechanism of the Ba‐Gua is constructed. The encoding process of the optical encoder is completed within a micro darkroom fabricated using 3D printing technology. This system incorporates virtual position encoding in conjunction with trigram orientation, requiring two keys for correct decryption: the “Combination Relative Optical Intensity Ratio” and the “Virtual Position Space Code”. By linking the ML emission spectrum with the trigram information, a dynamic, rewritable encryption system for hybrid encoding of digital and Chinese character based on Ba‐Gua evolution is established. The proposed optical encoder and dual‐key encryption system offer new directions for concealing confidential information and multidimensional encryption applications.
Rational Design of Natural Xanthones Against Gram‐negative Bacteria
Authors: Liu Xiaojia , Song Meirong , Liu Ying , Yang Shuyu , Chen Shang , Kang Jijun , Shen Jianzhong , Zhu Kui 
Published: January 2025

AbstractMost antibiotics are ineffective against Gram‐negative bacteria owing to the existence of the outer membrane (OM) barrier. The rational design of compounds to expand their antibacterial spectra of antibiotics solely targeting Gram‐positive pathogens remains challenging. Here, the design of skeletons from natural products to penetrate the OM are deciphered. Structure‐activity relationship analysis shows the optimization of the model of natural xanthones α‐mangostin endows the broad‐spectrum antibacterial activity. Mechanistic studies demonstrate the lead compound A20 penetrates the OM in a self‐promoted pathway through electronic and hydrophobic interactions with lipopolysaccharides and phospholipids in OM. A20 displays rapid bactericidal activity by targeting the cofactor heme in the respiratory complex. The therapeutic efficacy of A20 is demonstrated in two animal models infected with multidrug‐resistant Gram‐negative bacterial pathogens. The findings elucidate the structural property and self‐promoted transportation of a class of antibacterial compounds, to facilitate the design and discovery of antibacterial agents against increasingly prevalent Gram‐negative pathogens associated with infections.
Single‐Cell Hi‐C Technologies and Computational Data Analysis
Authors: Dautle Madison A , Chen Yong 
Published: January 2025

AbstractSingle‐cell chromatin conformation capture (scHi‐C) techniques have evolved to provide significant insights into the structural organization and regulatory mechanisms in individual cells. Although many scHi‐C protocols have been developed, they often involve intricate procedures and the resulting data are sparse, leading to computational challenges for systematic data analysis and limited applicability. This review provides a comprehensive overview, quantitative evaluation of thirteen protocols and practical guidance on computational topics. It is first assessed the efficiency of these protocols based on the total number of contacts recovered per cell and the cis/trans ratio. It is then provided systematic considerations for scHi‐C quality control and data imputation. Additionally, the capabilities and implementations of various analysis methods, covering cell clustering, A/B compartment calling, topologically associating domain (TAD) calling, loop calling, 3D reconstruction, scHi‐C data simulation and differential interaction analysis is summarized. It is further highlighted key computational challenges associated with the specific complexities of scHi‐C data and propose potential solutions.
Multifunctional Fluorescent Probe for Simultaneous Detection of ATP, Cys, Hcy, and GSH: Advancing Insights into Epilepsy and Liver Injury
Authors: Yu Ting , Li Yang , Li Jing , Gan Yabing , Long Zhengze , Deng Yun , Zhang Youyu , Li Haitao , Yin Peng , Yao Shouzhuo 
Published: January 2025

AbstractAdenosine triphosphate (ATP) is a critical intracellular energy currency that plays a key role in various cellular processes and is closely associated with numerous diseases. Similarly, biothiols such as glutathione (GSH), cysteine (Cys), and homocysteine (Hcy) are integral to many physiological and pathological processes due to their strong redox properties. Simultaneous discrimination and detection of ATP and biothiols offer valuable insights into the pathogenesis of conditions such as epilepsy and liver injury. This study introduces the first fluorescent probe, BCR, designed for multifunctional detection of ATP, GSH, Hcy, and Cys. With outstanding optical properties, excellent biocompatibility, high selectivity, and superior sensitivity, probe BCR enables effective imaging of ATP and biothiol dynamics in vivo. Moreover, probe BCR successfully visualizes changes in ATP, GSH, Hcy, and Cys levels in a PTZ‐induced epileptic zebrafish model and an APAP‐induced mouse liver injury tissue section model. These findings underscore the significant potential of probe BCR for early disease diagnosis and therapeutic applications.
Biomarker treatment effects in two phase 3 trials of gantenerumab
Authors: Bittner Tobias , Tonietto Matteo , Klein Gregory , Belusov Anton , Illiano Vittorio , Voyle Nicola , Delmar Paul , Scelsi Marzia A. , Gobbi Susanna , Silvestri Erica , Barakovic Muhamed , Napolitano Antonio , Galli Christopher , Abaei Maryam , Blennow Kaj , Barkhof Frederik 
Published: January 2025

AbstractINTRODUCTIONWe report biomarker treatment effects in the GRADUATE I and II phase 3 studies of gantenerumab in early Alzheimer's disease (AD).METHODSAmyloid and tau positron emission tomography (PET), volumetric magnetic resonance imaging (vMRI), cerebrospinal fluid (CSF), and plasma biomarkers used to assess gantenerumab treatment related changes on neuropathology, neurodegeneration, and neuroinflammation over 116 weeks.RESULTSGantenerumab reduced amyloid PET load, CSF biomarkers of amyloid beta (Aβ)40, total tau (t‐tau), phosphorylated tau 181 (p‐tau181), neurogranin, S100 calcium‐binding protein B (S100B), neurofilament light (NfL), alpha‐synuclein (α‐syn), neuronal pentraxin‐2 (NPTX2), and plasma biomarkers of t‐tau, p‐tau181, p‐tau217, and glial fibrillary acidic protein (GFAP) while increasing plasma Aβ40, Aβ42. vMRI showed increased reduction in whole brain volume and increased ventricular expansion, while hippocampal volume was unaffected. Tau PET showed no treatment effect.DISCUSSIONRobust treatment effects were observed for multiple biomarkers in GRADUATE I and II. Comparison across anti‐amyloid antibodies indicates utility of p‐tau and GFAP as biomarkers of amyloid plaque removal while NfL and tau PET seem unsuitable as consistent indicators of clinical efficacy. vMRI might be confounded by non‐neurodegenerative brain volume changes.TRIAL REGISTRATION NUMBER (CLINICALTRIALS.GOV IDENTIFIER):NCT03444870 and NCT03443973.Highlights
Gantenerumab significantly reduced brain amyloid load.
Tau positron emission tomography showed no treatment effect in a small subset of participants.
Volumetric magnetic resonance imaging showed increased whole brain volume reduction under treatment while hippocampal volume was unaffected.
Robust treatment effects on cerebrospinal fluid and plasma biomarkers were found, despite lack of clinical efficacy.
Total Synthesis of the Tridecasaccharide Motif from Angelica Sinensis APS‐1 II Polysaccharide with Anti‐Leukemia Activity and Structure‐Activity Relationship Studies
Authors: Guo Fuqiang , Tan Qiang , Guo Jiahui , Li Kaifeng , Wang Xiufang , Cao Wei , Xiao Guozhi 
Published: January 2025

AbstractA polysaccharide APS‐1 II from a medicinal plant Angelica sinensis (Oliv.) Diels represents a potential therapeutic agent against leukemia. However, the synthetic accessibility of the highly branched and complex APS‐1 II polysaccharide with multiple 1, 2‐cis‐glycosidic linkages remains a difficult task, impeding the in‐depth structure–activity relationship biological studies and the development of carbohydrates‐based therapeutics against leukemia. Here, we report the first chemical synthesis of tridecasaccharide repeating unit together with shorter sequences 4‐mer, 6‐mer and 9‐mer from APS‐1 II polysaccharide via one‐pot orthogonal glycosylation strategy based on glycosyl ortho‐(1‐phenylvinyl)benzoates, which precluded the potential issues such as aglycone transfer associated with one‐pot assembly with thioglycosides. The synthetic pathway also features the following aspects: 1) three contiguous and challenging 1, 2‐cis‐Fuc bonds were highly stereoselectively constructed via the newly developed stereoselective 1, 2‐cis‐fucosylation method; 2) several 1, 2‐trans‐glycosidic linkages were formed via neighboring group participation effect, while 1,2‐cis‐Glc linkage was stereoselectively assembled via N,N‐dimethylformamide reagent modulation; 3) the final [1+1+2+9] one‐pot assembly of the target tridecasaccharide via strategic utilizations of glycosyl N‐phenyltrifluoroacetimidates, ortho‐alkynylbenzoates and ortho‐(1‐phenylvinyl)benzoates. Biological studies revealed that human leukemia K562 and mouse L1210 cells could be effectively inhibited by tridecasaccharide repeating unit and substructure nonasaccharide.
Rational Design of Cobalt‐Based Prussian Blue Analogues via 3 d Transition Metals Incorporation for Superior Na‐Ion Storage
Authors: Jing Zhongxin , Mamoor Muhammad , Kong Lingtong , Wang Lu , Wang Bin , Chen Ming , Wang Fengbo , Qu Guangmeng , Kong Yueyue , Wang Dedong , He Xiyu , Wang Chang , Zhang Xintong , Zhang Yufei , Wang Gang , Xu Liqiang 
Published: January 2025

AbstractUnderstanding the relationship between structure regulation and electrochemical performance is key to developing efficient and sustainable sodium‐ion batteries (SIBs) materials. Herein, seven Cobalt‐M‐based (M=V, Mn, Fe, Co, Ni, Cu, Zn) Prussian blue analogues (CoM‐PBAs) are designed as anodes for SIBs via a universal low‐energy co‐precipitation approach with the strategic inclusion of 3d transition metals. Density Functional Theory (DFT) simulation and experimental validation reveal that a moderate p‐band center of cyanide linkages (−CN−) is more favorable for Na+ intercalation and diffusion, while the d‐band center of metal cations is linearly related to electrode stability. Among seven CoM‐based PBAs, CoV‐PBAs possess the best sodium‐ion adsorption/diffusion kinetics and overall cycling performance, including high specific capacity (565 mAh/g at 0.1 A/g), cycling stability (over 15000 cycles with 97.7 % capacity retention), and superior rate capability (174.7 mAh/g at 30 A/g). In situ/ex situ techniques further demonstrate that the π‐electron regulation by V introduction enhances the reversibility and kinetics of redox reactions. Moreover, the study identified the “p‐band center” and “d‐band center” may serve as key descriptors for quantifying the capability and stability of other‐type bimetal Co‐based anodes (oxides, phosphides, sulfides, and selenides) with similar theoretical capacity, offering a potentially transformative approach for selecting practical SIB electrode materials.
Asymmetric Synthesis of Inherently Chiral Tetraoxacalix[2]arene[2]pyridines via SNAr‐Based Cross‐Cyclotetramerization
Authors: Ibragimova Regina , Lu Qiu‐Lin , Wang Mei‐Xiang , Zhu Jieping , Tong Shuo 
Published: January 2025

AbstractPotassium phosphate‐promoted cross‐cyclotetramerization of 2,6‐dichloro‐3‐nitropyridine 1 with resorcinol derivatives 2 gave rise to thermodynamically favored 1,3‐alternate tetraoxacalix[2]arene[2]pyridines and kinetically controlled 1,2‐alternate isomers. The kinetic product could convert into its 1,3‐alternate conformational isomer by a macrocycle to macrocycle conversion pathway. Enantiomerically enriched C2‐symmetric inherently chiral tetraoxacalix[2]arene[2]pyridines were synthesized via a Cinchonine‐derived chiral phase‐transfer catalyst (PTC). This synthesis involved the cross‐cyclotetramerization of 1 with 2, featuring a key enantioselective intramolecular aromatic nucleophilic substitution (SNAr) step.
VS4/NCDs Nanowire as Efficient Cathode for Aqueous Rechargeable Zinc‐Ion Batteries
Authors: Ma Jinfeng , Jiu Hongfang , Zhang Lixin , Li Hui , Wang Congli , Che Sicong , Liu Xiaoqing , Guo Zhixin , Yue Luchao , Han Yuxin 
Published: January 2025

AbstractVS4 has emerged as a promising cathode material for aqueous zinc‐ion batteries (ZIBs), attracting significant interest due to its unique layered atomic chain structure and high capacity. However, the low electrical conductivity of the material limits the diffusion rate of zinc ions, ultimately compromising its structural stability. In this study, we demonstrate the synthesis of nanowires through a simple hydrothermal recombination of carbon dots on vanadium sulfide. The distinctive layered structure of VS4, in conjunction with nitrogen‐doped carbon dots (NCDs), increases the number of available active sites, thereby enhancing the conductivity of VS4/NCDs. VS4/NCDs cathode exhibits high specific capacity of 110 mAh g−1 at 5 A g−1 and superior rate performance in ZnSO4 electrolytes, significantly outperforming that of the layered VS4 cathode.
Probability and Fuzzy Working in Concert—Honoring the Reliability Contributions of Nozer D. Singpurwalla
Authors: Sellers Kimberly F. , Booker Jane M. 
Published: January 2025

ABSTRACTSince Lotfi Zadeh introduced fuzzy logic and fuzzy sets, this theory characterizing the uncertainty of classification has a proven record in fields of computation and engineering. These successful applications, however, have been falsely interpreted as competition or replacement of probability theory by those in many statistical and mathematical communities. Such misconceptions are the result of a lack of understanding about types of uncertainties, and anchored attitudes clinging to the past. Nozer Singpurwalla, among other statisticians, came to the realization that probability and fuzzy set theory can and should work in concert (i.e., not in competition) to accommodate two different types of uncertainty present within a problem or system. The authors had the honor to collaborate with Nozer; those works are featured as successful applications of the probability measure of fuzzy sets in reliability where respective uncertainties of the outcome of events and of classification exist. This paper features those works which embody the use of Bayesian analysis and the subjective interpretation of probability.
Porous Poly(Poly[Ethylene Glycol] Methyl Ether Methacrylate) Gel Polymer Electrolyte With Superior Electrochemical Properties in a High‐Performance Potassium‐Ion Battery
Authors: Zardehi‐Tabriz Ali , Anavi Hadiseh , Ghayebzadeh Yoones , Roghani‐Mamaqani Hossein , Salami‐Kalajahi Mehdi 
Published: January 2025

ABSTRACTPotassium‐ion batteries as a suitable alternative to lithium‐ion batteries have drawn attention due to available sources of potassium, low reduction potential, better diffusion through electrolyte/electrode interface, and good ionic conductivity. Here, a photopolymerized porous gel polymer electrolyte based on poly(poly[ethylene glycol] methyl ether methacrylate) and poly(methyl methacrylate) nanoparticles shows superior thermal and electrochemical properties. After swelling in a KPF6 and EC/PC solution, the best GPE demonstrates high ionic conductivity of 2.9 × 10−2 S cm−1, potassium transference number of 0.88, and high electrochemical stability of > 6 V. This excellent electrochemical property could be related to high solvent uptake, high surface area, K+ pathway channels, low Tg, and the electron donor groups of the porous poly(poly[ethylene glycol] methyl ether methacrylate). Also, this GPE shows an initial capacity of 155 mAh g−1, an initial Coulombic efficiency of ~100%, and capacity retention of 99.9% after 100 cycles in a high current density of 5 C with high‐voltage FeFe(CN)6 as the cathode and graphite as the anode. FE‐SEM images show the ability to suppress dendrites after 100 cycles of charge–discharge at 5 C. Additionally, this GPE demonstrates 143 mAh g−1 capacity at a very high C‐rate of 10, showing its ability for use in high‐performing rechargeable potassium batteries.
How Consumer Experience Shapes the Adoption of Autonomous Technologies: A Longitudinal Study With Shared Autonomous Vehicles
Authors: Schwing Maximilian , Reit Vanessa , Selinka Sarah , Kuhn Marc , Meyer‐Waarden Lars 
Published: January 2025

ABSTRACTTechnological advancements are rapidly driving the automation and autonomy of emerging technologies, products, and services. Consequently, understanding the factors that influence their adoption is critical for successful implementation. Real‐world consumer experiences can significantly reshape initial attitudes and influence the adoption process. This study investigates the determinants of adoption intention before and after first real‐world experience with the technology of shared autonomous vehicles. Utilizing regulatory focus theory, we integrate constructs from technology acceptance, trust‐risk and transformative consumer research. This approach allows us to assess the impact of perceived usefulness, technology trust, and subjective well‐being on adoption intention. To examine individual temporal changes, we conduct a within‐subject longitudinal study involving 148 users of an autonomous shuttle project and employ an evolution model approach for panel data. Our results reveal that perceived usefulness and technology trust remain stable antecedents, whereas the impact of subjective well‐being diminishes with user experience. These results highlight the importance of stable technological performance and trust in facilitating the adoption of artificial intelligence‐enabled technologies, suggesting that initial user experiences can significantly reshape subsequent usage intentions. Additionally, our study sheds light on the factors influencing these direct antecedents of intention to use.
Development of pH‐Responsive SA/PEGDA/AS‐POSS Hydrogels via Michael Addition for Controlled Drug Release and Enhanced Mechanical Properties
Authors: Meng Yang , Li Wen , Zhang Lingji , Berrettoni Mario , Zhang Hongzhong , Zhang Xiaojing 
Published: January 2025

AbstractIn this study, thiolated sodium alginate (SA) and hydrophilic, polymerizable Janus‐type polyhedral oligomeric silsesquioxane (AS‐POSS) are synthesized by introducing thiol and sulfonic acid groups, respectively. A series of pH‐responsive SA/PEGDA/AS‐POSS nanocomposite hydrogels are successfully prepared through Michael addition reactions between the thiol groups of thiolated sodium alginate and the double bonds in the molecular chains of AS‐POSS and poly(ethylene glycol) diacrylate (PEGDA). This reaction proceeds rapidly under physiological conditions without requiring initiators or catalysts. As the content of AS‐POSS increases, the pore size within the hydrogel decreases, and the network structure becomes denser, with significant improvements in mechanical properties. The hydrogel exhibits excellent pH sensitivity, showing lower swelling in acidic media compared to neutral media, and undergoing hydrolysis and losing stability in alkaline media. Moreover, the incorporation of AS‐POSS significantly enhances the drug‐loading capacity (85.7 %) and encapsulation efficiency (72.1 %) of doxorubicin (DOX). The drug is released faster in weakly acidic environments, with a cumulative release rate reaching 80.4 %, demonstrating excellent targeting and controlled release properties. Cytotoxicity tests show that the SA/PEGDA/AS‐POSS hydrogel has good biocompatibility and exhibits effective tumor‐killing ability, indicating its great potential as a drug carrier with promising applications in biomedical materials.
Bio‐Based Surfactants via Borrowing Hydrogen Catalysis
Authors: Koy Maximilian , Fellert Maximilian , Deng Chuting , Uiterweerd Michiel T. , Lessentier Alicia , Wu Minyan , Cregut Mickael , Zheng Jianxia , Streiff Stephane , de Pablo Juan J. , Feringa Ben L. 
Published: January 2025

AbstractA borrowing hydrogen approach to produce bio‐based surfactants is described. The process utilizes ubiquitous amino acids and common alcohols without protecting group manipulations. Surfactants are synthesized in a single step using a commercially available ruthenium‐based catalyst in a waste‐free manner with nearly ideal atom economy. The versatility of the products is shown by further derivatization resulting in novel Gemini surfactants and a related quaternary ammonia salt. The analysis of selected compounds shows remarkable properties as surfactants. Further studies show their potential biodegradability in nature, which enhances the broad application profile of the sustainable products prepared in this study.
Entrepreneurial architecture—A comparison among Europe, United States and Latin America universities
Authors: Ribeiro Artur Tavares Vilas Boas , Jorge Ricardo Reolon , Plonski Guilherme Ary , Gibson David Vandyke 
Published: January 2025

AbstractA cornerstone for economic growth, universities have been impelled to the entrepreneurial turn to transform their knowledge into innovations and new ventures. A common strategy from university managers is to rely on the best practices and benchmarks of entrepreneurial universities. However, universities are heterogeneous and context‐dependent, thus requiring an in‐depth understanding of their missions, structural characteristics, and regional history, among other factors. Using the entrepreneurial architecture approach, this paper presents space and place differences from universities in Europe, Latin America, and the United States. Data was collected from 41 leaders from universities worldwide and analyzed through lexicometry methods. Results indicate how heterogeneity implies distinct organizational structures in universities, such as in strategy making, science commercialization culture, and the role of Technology Transfer Offices.