bluuebunny/crossref_metadata_2025_split huggingface dataset:
Serum albumin and white matter hyperintensities
Authors: Zahr Natalie , Pfefferbaum Adolf 
Published: January 2024

Abstract

Urine albumin, high in kidney disease, predicts cardiovascular incidents and CNS white matter hyperintensity (WMH) burdens. Serum albumin – a more general biomarker which can be low in several disorders – including kidney and liver disease, malnutrition, and inflammation – also predicts cardiovascular events and is associated with cognitive impairment in several clinical populations; relations between serum albumin and WMH prevalence, however, have rarely been evaluated. In a sample of 160 individuals with alcohol use disorder (AUD), 142 infected with HIV, and 102 healthy controls, the hypothesis was tested that lower serum albumin levels would predict larger WMH volumes and worse cognitive performance irrespective of diagnosis. After considering traditional cardiovascular risk factors (e.g., age, sex, body mass index (BMI), nicotine use, hypertension, diabetes) and study-relevant variables (i.e., primary diagnoses, race, socioeconomic status, hepatitis C virus status), serum albumin survived false discovery rate (FDR)-correction in contributing variance to larger periventricular but not deep WMH volumes. This relationship was salient in the AUD and HIV groups, but not the control group. In secondary analyses, serum albumin and periventricular WMH along with age, sex, diagnoses, BMI, and hypertension were considered for hierarchical contribution to variance in performance in 4 cognitive domains. Albumin survived FDR-correction for significantly contributing to visual and verbal learning and memory performance after accounting for diagnosis. Relations between albumin and markers of liver integrity [e.g., aspartate transaminase (AST)] and blood status (e.g., hemoglobin, red blood cell count, red cell distribution width) suggest that in this sample, albumin reflects both liver dysfunction and hematological abnormalities. The current results suggest that albumin, a simple serum biomarker available in most clinical settings, can predict variance in periventricular WMH volumes and performance in visual and verbal learning and memory cognitive domains. Whether serum albumin contributes mechanistically to periventricular WMH prevalence will require additional investigation.
Effect Of Ultra-Short-Term Treatment of Patients with Iron Deficiency Or Anemia Undergoing Adolescent Scoliosis Correction, A Randomized Controlled Prospective Study.
Authors: Mostafa Tarek Abdel-Hay , Shamhout Ibraheem Ahmed , hagar Alaa Mohammed Abo , Omara Amany Faheem 
Published: January 2024

Abstract

Background: Red blood cell transfusions are necessary both during and after spine fusion surgery for scoliosis. The study aimed to evaluate the response of patients with iron deficiency or anemia undergoing adolescent scoliosis correction to ultra-short-term treatment with ferric carboxymaltose, subcutaneous erythropoietin, subcutaneous vitamin B12, and oral folic acid.
Methods: Forty-four patients aged 13 to 45 years with adolescent idiopathic scoliosis slated for surgical treatment by posterior fusion spine surgery were divided into two groups. One day before the operation, patients in the Therapy group received a gradual intravenous infusion of 20 mg/kg ferric carboxymaltose, 40.000 Unit subcutaneous erythropoietin, 1 mg subcutaneous vitamin B12, and 5 mg oral folic acid. Patients in the Control group got a placebo treatment. The number of red blood cell and platelet transfusions received during the first postoperative seven days, the perioperative Hemoglobin, reticulocyte, platelet, and leucocyte count, reticulocyte hemoglobin content, the need for fresh frozen plasma units, and intraoperative blood loss were recorded.
Results: The therapy group presented significantly lower mean value of intraoperative blood loss, number of patients who required platelet, fresh frozen plasma, and RBC transfusions than in the control group. The therapy group considerably enhances postoperative total leukocyte count and platelet count. In the therapy group, postoperative hemoglobin [HB], reticulocyte [RTC], and RTC-HB values were considerably greater than in the control group.
Conclusion: Preoperative combined administration of ferric carboxymaltose, erythropoietin, vitamin B12, and folic acid in adolescent idiopathic scoliosis correction one day before the surgery, could improve postoperative outcomes by optimizing preoperative anemia, reducing intraoperative blood loss and the number of patients requiring blood products and shorter intensive care unit [ICU] stay.
Trial registration: Registered on ClinicalTrials.gov with the ID: NCT04343170 on the date of April 2020. https://clinicaltrials.gov/ct2/show/NCT04343170
Switching, fast and slow: Deciphering the dynamics of memory search, its brain connectivity patterns, and its role in creativity
Authors: Tellez Marcela Ovando , Kenett Yoed , Benedek Mathias , Hills Thomas , Beranger Benoit , Lopez-Persem Alizée , Bieth Theophile , Volle Emmanuelle 
Published: January 2024

Abstract

Creative ideas emerge from searching, reorganizing, and combining ideas or concepts within memory. This involves an interplay between associative and controlled processes. How these processes occur during memory search varies between individuals and how they relate to creative abilities remain unclear. Here, we explored the neurocognitive correlates of semantic memory search by integrating concepts and methods from two distinct approaches: the clustering-switching characterization of responses typically explored in fluency tasks, and the principles of optimal foraging as proposed by the marginal value theorem. We used an associative fluency task involving polysemous words that enabled us to identify clusters and switches among responses with respect to the different meaning of the cue words. We additionally captured the reaction times of the retrieved words during the task, and explored individual patterns of memory search at the cognitive and brain level. Our results indicate that search in semantic memory follows a pattern consistent with optimal foraging. Furthermore, when measuring the time intervals between consecutive responses, we observed that switches during memory search occurred on average as predicted by the marginal value theorem. However, individual patterns of fast or slow clustering and switching related to creativity. Participants with more frequent slow-clustering during retrieval exhibited higher divergent thinking ability, whereas participants with more frequent fast-switching were better able to combine remote associates. Finally, patterns of slow clustering and fast switching were predicted by brain functional connectivity and mediated the brain connectivity-creativity relationship. Overall, we developed new measures of semantic search, identified neurocognitive correlates of semantic search patterns, and related them to creative abilities. Our findings uniquely highlight the significance of the type of search (clustering vs. switching), as well as its temporal modulation (slow vs. fast), in relation to individual differences in creativity.
Refractive error in premature infants without retinopathy of prematurity and full-term infants aged 1-18 months: a propensity score matching analysis
Authors: Huo Lu , Jia XinYu , Li ChunMei 
Published: January 2024

Abstract

Background
Premature birth signals increased risk for abnormal refractive development even without retinopathy of prematurity (ROP). This study aim to evaluate the differences in refractive error between premature infants without ROP and full-term infants, and to assess the relationship between physical parameters on birth and refractive status in premature infants.
Methods
A total of 1205 infants aged 1–18 months participated in this cross-sectional study at Tianjin Women’s and Children’s Health Center in China from February 2019 to September 2021. Propensity score matching (PSM) was used to balance the covariates between preterm infants without ROP and full-term infants, and the differences in refractive error between the two groups were compared to further analyze the gestational age (GA) of preterm infants, birth weight (BW), and birth length (BL). We exploited a simple linear regression model to determine the relationships between diopter and GA, BW, and BL in preterm infants.
Results
Of all participants, 230 pairs were successfully matched based upon propensity scores. MSE of preterm infants without ROP tended to be lower than that of full-term infants, but the overall difference was not statistically significant (P = 0.749). Compared with full-term infants, preterm infants without ROP also exhibited significantly higher prevalence of refractive error (69.1% vs. 79.1%, P = 0.014), emmetropia (8.3% vs.13.9%, P = 0.037), and astigmatism (47.4% vs. 56.1%, P = 0.040). While MSE was negatively correlated with BW and BL (R2 = 0.260, P < 0.001; R2 = 0.035, P = 0.004), there was no correlation between MSE and GA (R2 = 0.048, P = 0.051).
Conclusions
Compared with full-term infants, premature infants without ROP manifested higher prevalence of refractive error. The diopter of premature infants without ROP were significantly correlates better with BW more than it did to GA and BL, therefor BW was considered to evaluate the early refractive status of premature infants.
The role of leader nurse managers in organizational agility and innovation in perspective of job satisfaction: An empirical study in healthcare organizations
Authors: Akkaya Bulent , Popescu Catalin , Apostu Simona Andreea , Bagienska Anna , Üstgörül Sema 
Published: January 2024

Abstract

Aim
To determine the relationship between organizational agility and the innovation process in healthcare organizations and the mediating role of job satisfaction within this relationship.
Background
In a changing environment, organizational agility can be a skill supporting innovation in healthcare organizations. Nursing managers are leaders who play an important role in achieving the organizational results and coordinating the work of nurses.
Methods
The sample of the research was determined using the convenience sampling method consisted of 470 nurses working in healthcare organizations in west of Turkey. For statistical analysis of the data, we used the PLS-SEM approach to analyse the data, testing the hypotheses of current study.
Results
Organizational agility contributes to innovation in healthcare organizations. Moreover, job satisfaction is an important mediating factor in these relationships.
Conclusions
Nursing managers play an important role in the mechanism of shaping an innovative work environment based on organizational agility. Job satisfaction is one of the factors influencing this relationship, therefore organizations should strive to increase it.
The relationship of sleep duration with premature menopause in American adults: data from the National Health and Nutrition Examination Survey (NHANES) from 2005-2018
Authors: Li Ruiping , Zhang Meng , Li Wenyan , Guo Yuzhen 
Published: January 2024

Abstract

Objective
The correlation between sleep time and menopausal age is still unclear. This study investigated the causal relationship between sleep duration and premature menopause based on the National Health and Nutrition Survey (NHANES) database.
Materials and methods
This study included 4055 female participants in the NHANES database from 2005 to 2018, and used a logistic regression model to evaluate the relationship between sleep duration and menopausal age. Draw RCS curve to illustrate the relationship between sleep duration and menopause age. Short term sleep was defined as ≤ 7 hours of sleep per day, normal sleep was defined as 7.0-8.9 hours of sleep, and long-term sleep was defined a ≥ 9 hours of sleep per day. Premature menopause was defined as menopause before the age of 40.
Results
The average age of 4055 female participants was 62.26 ± 11.42.There was a significant correlation between sleep duration and menopausal age (P < 0.05).The results of the logistic regression model showed that short-term sleep (≤ 7 hours) was associated with premature menopausal age (≤ 40) (OR = 0.80; 95% CI: 0.66–0.98; P = 0.028), and after adjusting for potential confounding factors, short-term sleep (≤ 7 hours) was also associated with premature menopausal age (≤ 40) (OR = 0.82; 95% CI: 0.67–1.99; P = 0.049).The RCS results showed a U-shaped association between sleep time and menopausal age (P < 0.001), with a threshold of 7 hours for sleep time. Whether sleep time increases or decreases, the risk ratio of premature menopause shows an increasing trend.
Conclusion
Our cross-sectional analysis elucidated the U-shaped relationship between sleep duration and menopausal age among the American age group.
Thymol improves ischemic brain injury by inhibiting microglia-mediated neuroinflammation
Authors: Zhao Chenchen , Sun Liang , Zhang Yuxin , Shu Xin , Hu Yujie , Zhang Zhi , Xia Shengnan , Yang Haiyan , Bao Xinyu , Li Jingwei , Xu Yun 
Published: January 2024

Abstract

Background
Microglia-mediated inflammation is one of the key aggravating factors in the development of ischemic stroke. Therefore, ameliorating microglial over-activation is a potential therapeutic target for ischemic injury. Thymol is a monophenol isolated from plant essential oil, which has various beneficial biological activities including anti-inflammatory and antioxidant, and protective effects in many disease models. However, its effects on ischemic stroke or microglial inflammation have not been reported.
Methods
Rodent transient middle cerebral artery occlusion (tMCAO) model was established to simulate ischemic stroke. TTC, modified neurological function score (mNSS) and behavioral tests were used to assess the severity of neurological damage. Then immunofluorescence staining and cytoskeleton analysis were used to determine activation of microglia. Lipopolysaccharide (LPS) was utilized to induce the inflammatory response of primary microglia in vitro. Quantitative real-time polymerase chain reaction (qRT-PCR), western blot and enzyme-linked immunosorbent assay (ELISA) were performed to exam the expression of inflammatory cytokines. And western blot was used to investigate the mechanism of the anti-inflammatory effect of thymol.
Results
In this study, we found that thymol treatment could ameliorate post-stroke neurological impairment and reduce infarct volume by reducing microglial activation and pro-inflammatory response (IL-1β, IL-6 and TNF-α). Mechanically, thymol could inhibit the phosphorylation of phosphatidylinositol-3-kinase (PI3K), sink serine/threonine kinase (Akt) and mammalian target of rapamycin (mTOR), and suppress the activation of nuclear factor-κB (NF-κB).
Conclusions
Our study demonstrated that thymol could reduce the microglial inflammation by targeting PI3K/Akt/mTOR/NF-κB signaling pathway, and further alleviate ischemic brain injury, suggesting that thymol is a promising candidate as a neuroprotective agent against ischemic stroke.
Assessment of Variability and Genetic Divergence of Longan Genotypes (Dimocarpus longan Lour.) based on Qualitative and Quantitative Traits
Authors: Kumar Ajay , Gupta A. K. , Kanth Neeharika , Marboh E. S. , Yadav Sudheer Kumar 
Published: January 2024

Abstract

Longan (Dimocarpus longan Lour.) is an important underutilized fruit crop. There is currently limited information available on the genetic background of longans, which is a key bottleneck in longan improvement. Studies on the extent of genetic variability and genetic divergence are crucial and it can provide relevant information which can be very useful for crop improvement programmes. In the present study, a total of 54 qualitative and quantitative traits were investigated of 20 different longan genotypes to determine the morphological and physiochemical traits that. Results revealed that the significant variability is existed in the studied traits except few. Among the qualitative traits petiole colour, leaflet curvature, young leaf colour, mature leaf colour, branching density, leaflet midrib colour, abundance of flower, trunk surface, fruit maturity group, and tree vigour were showed more than the average value of Shannon’s diversity index. Higher PCV and GCV were recorded for several traits viz., tree volume followed by aril weight, number of fruits per branch, aril/seed weight ratio, trunk girth, TSS acid ratio, aril thickness, number of days from panicle initiation to flowering, titratable acidity, width of inflorescence, length of inflorescence, petiole length, fruit weight, plant height, crown diameter and rachis length. High heritability estimates coupled with high genetic advance as % of mean were recorded for the traits viz., plant height, trunk girth, crown diameter, tree volume, rachis and petiole length, number of days from panicle initiation to flowering, length and width of inflorescence, number of fruits per bunch, fruit, aril and seed weight, aril thickness, fruit colour-a, titratable acidity and TSS acid ratio which is indicative of additive gene action and selection based on these traits would be more reliable. According to the Mahalanobis D2 statistic, twenty diverse genotypes were grouped into eight groups. The presence of genetic divergence was also tested in cluster means by the significant amount of variability for various variables. Therefore, this study's findings imply that these genotypes have variability in terms of fruit quality traits, yield and traits that contribute to yield, and other agronomic traits that could be useful in future crop improvement initiatives.
Degradation of Anthraquinone Dye Wastewater by Sodium Percarbonate with CoO Heterogeneous Activation
Authors: Fan Haoyu , Xia Yanzhao , Sun Cuizhen , Liu Rupeng , Chen Feiyong , Li Meng , Zhu Weichen , Yang Xinpeng , Zhang Zhen 
Published: January 2024

Abstract

In this work, the optimal efficiency and mechanism of action of CoO activated sodium percarbonate (SPC) for the degradation of Reactive Blue 19 was investigated. The three-factor interaction of SPC concentration, CoO dosage and initial pH and the effects of factors such as anions and humic acids (HA) were investigated. The results show that the CoO/SPC system (93.8%, 0.01015 min− 1) efficiently degraded RB19 and was also suitable for other organic dyes (32.7%~100%) and antibiotics (97.1%~100%). During the activation of SPC by CoO, carbonate radical (CO3•−), hydroxyl radical (•OH), superoxide radical (O2•−) and singlet oxygen (1O2) are involved in the degradation process, among which CO3•− (88.2%) plays an indispensable role, which was proved by quenching experiments and electron paramagnetic resonance (EPR) tests. Co2+ dissolution was lower than 150 µg/L, which meets the emission standard (1 ppm); the application of SPC avoids the problem of acidification of the wastewater, and the final product is green in color. This study presents a novel approach to treating dye wastewater by combining transition metal oxides with sodium percarbonate.
Characterizing and Forecasting Neoantigens Resulting from MUC Mutations in COAD
Authors: Chen Min , zhang xin , Ming Zihe , Feng Xiaorong , An Han-Xiang , yu Ling , Zhenguo Han 
Published: January 2024

Abstract
Background: The treatment for colon adenocarcinoma (COAD) faces challenges in terms of immunotherapy effectiveness due to multiple factors. Because of the high tumor specificity and immunogenicity, neoantigen has been considered a pivotal target for cancer immunotherapy. Therefore, this study aims to identify and predict the potential tumor antigens of MUC somatic mutations (MUCmut) in COAD.
Methods: Three databases of TCGA, TIMER2.0, and cBioPortal were used for a detailed evaluation of the association between MUCmut and multi-factors like tumor mutation burden (TMB), microsatellite instability (MSI), prognosis, and the tumor microenvironment within the context of total 2242 COAD patients. Next, TSNAdb and the differential agretopicity index (DAI) were utilized to predict high-confidence neopeptides for MUCmut based on 531 COAD patients' genomic information. DAI was calculated by subtraction of its predicted HLA binding affinity of the MUCmut peptide from the corresponding wild-type peptide.
Results: The top six mutation frequencies (14 to 2.9%) were from MUC16, MUC17, MUC5B, MUC2, MUC4 and MUC6. COAD patients with MUC16 and MUC4 mutations had longer DFS and PFS. However, patients with MUC13 and MUC20 mutations had shorter OS. Patients with the mutation of MUC16, MUC5B, MUC2, MUC4, and MUC6 exhibited higher TMB and MSI. Moreover, these mutations from the MUC family were associated with the infiltration of diverse lymphocyte cells and the expression of immune checkpoint genes. Through TSNAdb 1.0/NetMHCpan v2.8, 452 single nucleotide variants (SNVs) of MUCmut peptides were identified. Moreover, through TSNAdb2.0/NetMHCpan v4.0, 57 SNVs, 1 Q-frame shift (TS), and 157 short insertions/deletions (INDELs) of MUCmut were identified. Finally, 10 high-confidence neopeptides of MUCmut were predicted by DAI.
Conclusions: In conclusion, this study showed the immunogenic role of neoantigens against MUCmut in COAD. Through combining the tools of TSNAdb and DAI, a group of novel MUCmut neoantigens were identified as potential targets for immunotherapy.
Research on the optimal detection location of rail RCF crack under fast moving condition
Authors: Liu Jianjun , Li Jian 
Published: January 2024

Abstract
in this paper, the influence of shadow effect on the accuracy of crack detection in fast motion is studied. Through the finite element simulation analysis, the change of the magnetic field distribution on the rail surface under the trailing effect is explored, and the intensity and sensitivity of the detection signals at different detection positions are compared. By comparing the results, an optimal detection position with high signal strength and sensitivity is determined, and the best probe structure suitable for fast-moving electromagnetic nondestructive testing is proposed. The results show that the probe structure can effectively characterize the crack with a crack depth of more than 1.0mm when the detection speed reaches 20.0m/s, and the relative error and standard deviation are both less than 10%.
Transcriptome analysis of cynomolgus macaques throughout their lifespan reveals age-related immune patterns
Authors: Huh Jae-Won , Cho Hyeon-Mu , Choe Se-Hee , Lee Ja-Rang , Park Hye-Ri , Ko Min-Gyeong , Lee Yun-Jung , Lee Hwal-Yong , Park Sung Hyun , Park Sang-Je , Kim Young-Hyun 
Published: January 2024

Abstract

Despite the different perspectives by diverse research sectors spanning several decades, aging research remains uncharted territory for human beings. Therefore, we investigated the transcriptomic characteristics across the entire lifespan of laboratory monkeys, meticulously shielded from all environmental factors except aging. The results showed recent findings of certain immune response and the age-associated network of primate immunity. Three important aging patterns were identified and each gene clusters represented a different immune response. The increased pattern was predominantly associated with innate immunity whereas the other two decreased patterns were associated with adaptive immunity. Furthermore, the hub gene network of the patterns reflected transcriptomic age and correlated with human illness status, aiding in future human disease prediction. Our macaque transcriptome profiling results offer systematic insights into the age-related immunological features of primates.