bluuebunny/crossref_metadata_2025_split huggingface dataset:
Gene Expression Signatures Predict First-Year Response to Somapacitan Treatment in Children With Growth Hormone Deficiency
Authors: Garner Terence , Clayton Peter , Højby Michael , Murray Philip , Stevens Adam 
Published: December 2023

Abstract

Context
The pretreatment blood transcriptome predicts growth response to daily growth hormone (GH) therapy with high accuracy.

Objective
Investigate response prediction using pretreatment transcriptome in children with GH deficiency (GHD) treated with once-weekly somapacitan, a novel long-acting GH.

Methods
REAL4 is a randomized, multinational, open-label, active-controlled parallel group phase 3 trial, comprising a 52-week main phase and an ongoing 3-year safety extension (NCT03811535). A total of 128/200 treatment-naïve prepubertal children with GHD consented to baseline blood transcriptome profiling. They were randomized 2:1 to subcutaneous somapacitan (0.16 mg/kg/week) or daily GH (0.034 mg/kg/day). Differential RNA-seq analysis and machine learning were used to predict therapy response.

Results
121/128 samples passed quality control. Children treated with somapacitan (n = 76) or daily GH (n = 45) were categorized based on fastest and slowest growing quartiles at week 52. Prediction of height velocity (HV; cm/year) was excellent for both treatments (out of bag [OOB] area under curve [AUC]: 0.98-0.99; validation AUC: 0.83-0.84), as was prediction of secondary markers of growth response: HV standard deviation score (SDS) (0.99-1.0; 0.75-0.78), change from baseline height SDS (ΔHSDS) (0.98-1.0; 0.61-0.75), and change from baseline insulin-like growth factor-I SDS (ΔIGF-I SDS) (0.96-1.0; 0.85-0.88). Genes previously identified as predictive of GH therapy response were consistently better at predicting the fastest growers in both treatments in this study (OOB AUC: 0.93-0.97) than the slowest (0.67-0.85).

Conclusion
Pretreatment transcriptome predicts first-year growth response in somapacitan-treated children with GHD. A common set of genes can predict the treatment response to both once-weekly somapacitan and conventional daily GH. This approach could potentially be developed into a clinically applicable pretreatment test to improve clinical management.
Niemann-Pick Disease With Bilateral Adrenal Mass
Authors: Long Mohd Noor Affendi Sharifah Noor Adrilla binti , Tong Chin Voon , Nordin Nurul Dayana binti 
Published: December 2023

Abstract
Niemann–Pick disease (NPD) is a heterogeneous group of lysosomal storage disorders with autosomal recessive inheritance pattern. There are 4 types of NPD. Patients with NPD type B generally have better prognosis, allowing them to survive into adulthood. They have a widespread clinical presentation, affecting multiple organs but rarely neurological involvement. Here, we describe the case of a 38-year-old woman with unexplained hepatosplenomegaly and young hypertensive intracranial bleed. Evaluation for young hypertension further revealed a nonfunctional bilateral adrenal mass and gross hepatosplenomegaly. NPD was confirmed through dried blood spot investigation. It showed low activity of acid sphingomyelinase and genetic testing also detected 2 pathogenic mutations. She is being managed by a multidisciplinary team for supportive treatment that includes regular symptoms monitoring and genetic counseling.
THE 14TH INFANTRY DIVISION OF THE SOUTH-EASTERN FRONT IN OCTOBER-DECEMBER 1919
Authors: Gnido Sergey V. 
Published: December 2023

Purpose. The purpose of the article is to investigate the general nature and the main content of combat operations of the 14th Infantry Division, as well as the party-political work of its command to fulfill the combat tasks in the period from September 1919, when the division joined the newly formed Southeastern Front of the Red Army, and up to the forcing of the Don and the beginning of active combat operations on its right bank (December 1919).
Method and methodology. The general methodological approach to the research is based on the basic principles and methods of scientific and historical cognition. The priority scientific methods in this study were the general scientific methods of analysis, synthesis, classification, analogy, as well as methods of historical analysis (descriptive, comparative-historical, logical, retrospective, method of frontal analysis of archival materials).
Results. The results of the research showed that the 14th Division of the 9th Army of the Southeastern Front was able to recover from its almost complete defeat in early October 1919. It continued to fulfill the tasks on its section of the front. In the life of the division there was a place for party-political work. Going on the offensive to the Khoper River, the division with its actions restrained the enemy forces. Having accomplished the task, the division from the beginning of December went on the active offensive to the Don River. Having forded the Don River, the division continued the offensive on the right bank.
The scope of applicability of results. The results of the research can contribute to a more in-depth study of the Civil War in the period from October to the end of December 1919.
AXIOLOGICAL ASPECT OF THE CONCEPT IDENTITY OPPOSITION REALIZATION (BY THE EXAMPLE OF THE CREATION ‒ DESTRUCTION DICHOTOMY)
Authors: Zdanovskaya Lidia B. 
Published: December 2023

Background. The global redistribution of the balance of power, caused by the imbalance of the geopolitical interests of the leading world powers, contributed to the actualization within the boundaries of the Russian linguistic and cultural space of phenomena associated with the accentuation of existential significance categories among which the concept IDENTITY occupies a special position.
Purpose. The article is devoted to the study of the implementation of the value aspect of the concept IDENTITY opposition in Russian linguistic culture.
Materials and methods. The material for this study was the article of the President of the Russian Federation V.V. Putin On the historical unity of Russians and Ukrainians. July, 12, 2021; interview with the Minister of Foreign Affairs of the Russian Federation S.V. Lavrov; Internet publication of the Russian journalist I.A. Yakovenko Disintegration of the Russian Federation: Scenarios and Prospects; speeches of state and political figures of Russia in the television political show Evening with Vladimir Solovyov. When writing the article, the following methods were used: lexical-semantic, comparative-contrastive, discursive, contextual analysis.
Results. In the course of the study the specifics of the differentiated objectification of the concept IDENTITY in the Russian language were analyzed; various theoretical approaches to the substantiation of the oppositional nature of the language implementation of the concept under study were systematized; the factual interdependence of the studied concept with the category “linguistic consciousness” was established; an integrative feature of the implementation of the concept IDENTITY in the Russian language space was revealed; the indicative characteristic of the concept IDENTITY in the composition of the subjects of the opposition CREATION ‒ DESTRUCTION was described.
Practical implications. The results of the study can find practical application in the preparation of teaching aids and textbooks on the linguo-cognitive analysis of concepts based on dichotomous models.
Non-Mass-Forming Myeloid Sarcoma of the Colon Presenting With Diarrhea
Authors: Elsharawi Ibrahim , Williams Stacey , Stueck Ashley 
Published: December 2023

ABSTRACT
A female patient in her mid-70s, with a history of diverticulosis, presented with a 2-month history of severe diarrhea, left lower quadrant abdominal pain, decreased appetite, and fever. She was treated for diverticulitis, but did not improve. Subsequent workup revealed leukocytosis and circulating myeloblasts on a peripheral blood smear. Bone marrow evaluation and flow cytometry confirmed the diagnosis of acute myeloid leukemia. Abdominal computed tomography and sigmoidoscopy were performed for her persistent diarrhea. While both failed to show an obvious mass or anatomical abnormality, pathology from the colorectum showed infiltration by leukemic cells consistent with myeloid sarcoma. The diarrhea improved with acute myeloid leukemia chemotherapy.
Clip Dislodgement After Full-Thickness Endoscopic Resection Device Removal of Scarred Gastric Subepithelial Lesion Leading to Delayed Perforation
Authors: Johnson Peter C. , Agnihotri Abhishek , Loren David E. , Kowalski Thomas E. , Schlachterman Alexander , Kamal Faisal , Kumar Anand 
Published: December 2023

ABSTRACT
Endoscopic full-thickness resection using a full-thickness resection device is a newer technique for endoscopic removal of submucosal lesions not amenable to endoscopic mucosal resection or endoscopic submucosal dissection. There is a low rate of complications reported, although we report 2 cases of delayed perforation caused by dislodgement of a full-thickness resection device clip after removal of scarred gastric lesions. Both were managed endoscopically with good outcomes. However, special attention and consideration of alternative closure techniques should be considered with scarred gastric lesions and possible changes to the clip design could be considered.
Adsorpsi Minyak dan Timbal (Pb) pada Air Limbah Bengkel Mobil Menggunakan Bentonit dan Cangkang Telur Ayam (Gallus domesticus) sebagai Adsorben
Authors: Pratiwi Aldila Tirta , Widiatmono Bambang Rahadi , Wirosoedarmo Ruslan 
Published: December 2023

Minyak yang terkandung dalam oli yang digunakan termasuk komponen organik yang bersifat tetap dan sukar diuraikan bakteri, sedangkan timbal (Pb) memiliki sifat tidak dapat terurai secara hayati dan konsentrasinya tinggi terakumulasi di lingkungan. Pada penelitian dilakukan pengolahan air limbah bengkel dengan cara adsorpsi menggunakan adsorben bentonit dan cangkang telur ayam (Gallus domesticus) yang memiliki sifat ramah lingkungan dan keberadaannya selalu ada sepanjang tahun. Proses adsorpsi yaitu memanfaatkan kemampuan zat padat untuk menjerap suatu bahan atau zat pada permukaannya. Penelitian ini menggunakan variasi jenis dan dosis adsorben dengan lama waktu pengadukan selama 60 menit dengan kecepatan 150 rpm. Jenis adsorben yang digunakan yaitu clay jenis bentonit yang telah diaktivasi dengan larutan asam HCl 1 M dan cangkang telur ayam (Gallus domesticus). Faktor yang digunakan merupakan dosis bentonit dan cangkang telur ayam (Gallus domesticus) yang masing-masing terdiri dari 4 (empat) perlakuan yaitu 0 gram, 5 gram, 10 gram dan 15 gram. Penelitian bertujuan untuk mengetahui, menganalisis dan mengevaluasi efisiensi penurunan kadar minyak dan timbal (Pb). Adsorben bentonit dan cangkang telur ayam (Gallus domesticus) memberikan pengaruh terhadap efisiensi penurunan minyak secara signifikan namun tidak pada efisiensi penurunan timbal (Pb). Perlakuan adsorben bentonit sebesar 15 gram dengan cangkang telur ayam sebesar 15 gram (B3C3) menunjukkan kadar minyak paling sedikit yaitu 3,00 mg/L dengan efisiensi penurunan minyak paling besar yaitu 88,22%. Perlakuan adsorben bentonit sebesar 15 gram dengan cangkang telur ayam sebesar 10 gram (B3C2) menunjukkan timbal (Pb) paling sedikit yaitu 1,66 mg/L dengan efisiensi penurunan timbal (Pb) paling besar yaitu 52,25%.
Tumbuhan Air Invasif Berpotensi sebagai Fitoremediator Bahan Organik Total (BOT) di Waduk Darma Kuningan
Authors: Nurdin Nurdin , Ismail Agus Yadi , Kosasih Dede , Deni Deni , Herlina Nina 
Published: December 2023

ABSTRAKTumbuhan air merupakan bagian penting dari ekosistem perairan yang terbentuk dari adapatasi morfologi dan fisiologi sehingga tercipta pola hidup yang muncul di permukaan air, terendam dan mengapung bebas. Selain berfungsi secara ekologis organisme ini mampu menjadi fitoremediator untuk menjaga kualitas perairan. Tujuan khusus dari penelitian ini adalah untuk menginventarisasi tumbuhan air yang berpotensi sebagai fitoremediator di Waduk Darma Kuningan. Hasil penelitian ini dapat dipergunakan untuk pengelolaan waduk yang berkelanjutan, sehingga pemanfaatan waduk dapat sesuai dengan fungsinya. Penelitian ini juga terkait dengan komitmen United Nations Environment Programme (UNEP) terhadap keberlanjutan lingkungan hidup secara komprehensif. Tumbuhan air yang dimanfaatakan sebagai fitoremediator harus memiliki tingkat pertumbuhan yang tinggi, investasi bniomassa yang besar dan mampu beradaftasi dengan kondisi lingkungan yang esktrim. Eceng gondok (Eichhornia crasspes) merupakan tumbuhan air yang paling tepat dipergunakan sebagai fitoremediator di perairan Waduk Darma.Kata kunci: tumbuhan air, invasif, fitoremedias, waduk
Peran Stakeholder dalam Kajian Lingkungan Hidup Strategis Rencana Detail Tata Ruang Kawasan Perkotaan Manokwari
Authors: Kocu Yullyus , Bawole Roni , Pattiasina Thomas , Hematang Francine 
Published: December 2023

Dokumen Kajian Lingkungan Hidup Strategis (KLHS) Rencana Detil Tata Ruang (RDTR) Kawasan Perkotaan Manokwari ditujukan untuk mengendalikan aktifitas pembangunan di kawasan perkotaan agar serasi, terpadu, dan dapat meningkatkan kesejahteraan masyarakat. Adanya peran serta stakeholder dalam penyusunan KLHS RDTR adalah salah satu hal yang dapat menjadi penentu keberhasilan dalam penegakan aturan mengenai tata ruang. Tujuan penelitian ini adalah untuk mengkaji peran (pengaruh dan kepentingan) stakeholder dalam penyusunan dokumen KLHS RDTR Kawasan Perkotaan Manokwari. Pengumpulan data dilakukan dengan cara Porposive sampling. Analisis yang digunakan adalah stakeholder analysis (SA) mengunakan Matriks Brysson untuk mengidentifikasi dan mengkategorikan stakeholder. Hasil identifikasi menunjukan terdapat 18 pemangku kepentingan yang terlibat dalam penyusunan KLHS RDTR Kawasan Perkotaan Manokwari dengan perannya masing-masing. Di antara para pemangku kepentingan/stakeholder tersebut yang termasuk dalam stakeholder kunci yang memiliki pengaruh kuat dan peranan penting dalam penyusunan dokumen KLHS RDTR yaitu terdapat dua dua organisasi perangkat daerah Provinsi Papua Barat yaitu Dinas Pekerjaan Umum dan Perumahan Rakyat (PUPR) Provinsi Papua Barat, serta Kesatuan Pengelolaan Hutan Lindung (KPHL) unit XII, Organisasi perangkat daerah yang berasal dari kabupaten manokwari diantaranya Dinas Pekerjaan Umum dan Penataan Ruang, Badan Perencanaan Pembangunan Daerah, Dinas Lingkungan Hidup dan Pertanahan serta Dinas Perumahan dan permukiman masyarakat. Meskipun pemerintah telah mengacu pada peraturan perundang-undangan, namun secara pelaksanaannya penyusunan KLHS RDTR masih belum maksimal dalam melibatkan peran serta Stakeholder. Diperlukan kajian cepat terkait peran stakeholder sebelum dilakukan KLHS sehingga peran semua stakeholder bisa lebih maksimal. Selain itu perlu adanya regulasi atau protap sebagai alur komunikasi sehingga penyusunan dokumen perencanaan dapat terintegrasi dan interaksi antar-pemangku kepentingan menjadi lebih baik.
Penilaian Status dan Risiko Ekologi Cemaran Logam Berat di Lahan Pertanian Kota Malang, Provinsi Jawa Timur
Authors: Handayani Cicik Oktasari , Sukarjo Sukarjo , Zu'amah Hidayatuz , Dewi Triyani 
Published: December 2023

Akumulasi logam berat pada tanah memberikan dampak yang besar bagi lingkungan seperti dapat mengganggu keseimbangan ekologi, mengurangi kesuburan tanah, mengubah kualitas fisikokimia tanah dan sangat berbahaya bagi kesehatan manusia. Penelitian ini bertujuan untuk menganalisis status logam berat pada tanah dan kemungkinan terjadinya dampak ekologi yang tidak diinginkan pada lingkungan akibat adanya cemaran logam berat pada lahan pertanian Kapaten Malang. Penelitian ini menggunakan metode survey pengambilan contoh tanah dengan jumlah titik lokasi pengambilan contoh tanah sebanyak 123 titik. Analisis yang dilakukan antara lain analisis spasial, geoaccumulation index (I-Geo), polltuion index (PI), the Nemerow integrated pollution index (NIPI), dan potential ecological risk index (RI). Hasil dari penelitian ini menunjukkan bahwa logam Pb, Cd, Co, Ni, Cr, Cu, Mn, Zn dan As terdeteksi hampir di semua lokasi pengambilan contoh tanah pada lahan pertanian Kota Malang. Hasil analisis geoaccumulation index (I-geo), pollution index (PI), the Nemerow integrated pollution index (NIPI) dan potential ecological risk index (RI) menunjukkan hasil yang selaras bahwa logam Cd merupakan sumber utama pencemaran logam berat di lahan pertanian Kota Malang dengan nilai pencemaran yang cukup tinggi sehingga juga memiliki dampak ekologis yang tinggi.
CT measurement of damage characteristics of meso-structure of freeze-thawed granite in cold regions and preliminary exploration of its mechanical behavior during a single freeze-thaw process
Authors: Zhang Chunyang , Tan Tao , Ke Bo , Ma Bingde , Dai Bibo , Fang Zhiheng , Zhao Ercheng 
Published: December 2023

Abstract
The freeze-thaw (FT) damage characteristics of granite after different FT cycles were studied using computed tomography (CT) images. The three-dimensional (3D) volume numbers in the image were extracted to obtain the 3D pore structure of representative volume elements (RVEs) of granite under different FT cycles. The CT images of granite after 80 FT cycles were selected to draw reference lines for quantitative analysis of the distribution of meso-cracks in granite after FT cycles. Subsequently, a finite element model was established to explore the mechanical properties of minerals in granite during a single FT process. The results show that the FT damage inside the granite exhibits fracture characteristics, and the number of internal cracks, cracks area, and voxel porosity increase with the increase of FT cycles. After 80 FT cycles, the distribution of meso-cracks on the cross-section of granite exhibits significant anisotropy, and the distribution density and variation coefficient of meso-cracks vary with the dip direction angle of the reference line. The maximum principal stress and strain in the finite element model are negatively related to temperature. The maximum principal stress and strain of biotite minerals are consistently higher than those of feldspar and mica during FT cycles. The results can provide a reference for exploring the internal mechanism of the weakening of mechanical properties of granite microstructure caused by FT damage in cold regions.
Enhancing the therapeutic efficacy of Krestin–chitosan nanocomplex for cancer medication via activation of the mitochondrial intrinsic pathway
Authors: Albalawi Karma , Panneerselvam Chellasamy , Moawadh Mamdoh S. , Alalawy Adel I. , Omran Awatif M. E. , Abdelaziz Mahmoud A. , Mohammedsaleh Zuhair M. , Al-Aoh Hatem A. , Mustafa Syed Khalid , Keshk Ali A. , Al-Morwani Majed M. , Alessa Ali Hamzah , Al-Anazi Menier , Khateeb Sahar 
Published: December 2023

Abstract
Surgery, chemotherapy, and radiation therapy are all forms of cancer treatment, as well as more recent methods including interventional radiology and immunotherapy. In this study, we synthesize a novel chitosan (CH) nanocomplex (NC)-based polysaccharide Krestin (PSK) for drug delivery. This technique was used to develop PSK@CH@NC. According to the study, PSK@CH@NC had a particle size of around 500 nm, slight polydispersity as observed under a scanning electron microscope, and a strong positive surface charge of 18 mV. Investigation into the in vitro growth inhibition of the MCF-7 cell line after treatment with CH, PSK, and PSK@CH@NC was followed by morphological changes. Compared to other treatment groups, PSK@CH@NC therapy dramatically reduced the fraction of apoptotic cells, cancer cell survival, and proliferation. Fluorescence analysis was used to examine how PSK@CH@NC affected the distribution of cell cycle phases. This study also shows that a promising foundation for creating cancer nanomedicine can be established by employing new polysaccharides.
Effect of atmospheric pressure cold plasma on the physiochemical characteristics and Fourier transform infrared spectroscopy analysis of hazelnuts and peanuts
Authors: Medvecká Veronika , Mošovská Silvia , Mikulajová Anna , Zahoranová Anna 
Published: December 2023

Abstract
Consuming nuts in their raw form becomes a significant concern due to the presence of microbial contamination. The efficacy of low-temperature plasma (LTP) for inactivating fungi on nuts is already known. However, it is also necessary to examine the impact of this technique on physiochemical parameters to demonstrate the safety of LTP, especially when considering its practical application. The aim of the study is the investigation of the effect of LTP on physiochemical parameters, and the possible impact on the ageing of selected nut samples. LTP was generated in ambient air using diffuse coplanar surface barrier discharge (DCSBD). Based on FTIR analysis, no significant changes were detected on the surface of peanuts. In hazelnuts, moderate changes were recorded mainly in regions belonging to lipids. Changes inside the samples were not detected. A slight increase of polyphenol, flavonoid content and antioxidant activity was observed.
Metaphorical images in the mirror: How Romanian literary translators see themselves and their translations
Authors: Pungă Loredana 
Published: December 2023

Abstract
This study focuses on how 15 Romanian literary translators metaphorically conceptualize their own role and importance and the role and significance of their translations. The aim of the analysis is to see what kind of source text–target text and author–translator relationships the conceptual metaphors suggested reflect, to zoom in on the status of the translator and of the translated text that may be inferred based on these conceptualizations and, finally, to see whether they support the traditional source vs target-orientation dichotomy in translation or call for a more hermeneutic-oriented approach.
Green synthesis of copper nanoparticles from agro-waste garlic husk
Authors: Senthilkumar Anupama , Muthuswamy Razia , Uma Maheshwari Nallal  , Ramaiyan Sankar , Kannan Prabha , Muthupandi Sankar , Lakshminarayanan Srimathi Priya , Sambasivam Sangaraju , Ayyar Manikandan 
Published: December 2023

Abstract
The objective of this study was to test the antibacterial activity of copper nanoparticles (Cu NPs) against bacterial pathogens by green synthesizing them from aqueous extracts of garlic husk. The synthesized Cu NPs were examined by UV-visible (UV-VIS) spectroscopy at (200–400 nm), Fourier transform infrared (FTIR) spectroscopy, X-ray diffraction (XRD) analysis, transmission electron microscopy (TEM), and zeta potential analysis. The findings supported the capping, reduction, and production of Cu NPs with an average crystalline size of 14 nm in the husk extract. The minimum inhibitory concentration technique (MIC test) was used to measure the antibacterial activity against Gram-positive (Escherichia coli, Vibrio cholera) and Gram-negative (Bacillus cereus, Staphylococcus aureus) microorganisms. The lowest concentration required for inhibiting the growth of the bacterial strains ranged from 34.7 to 43.04 μg/ml. The above findings suggest that greenly synthesized Cu NPs made from garlic agro-waste may have potential uses in the realm of nanomedicine as an antibacterial drug in the treatment and prevention of bacterial infections due to their superior antibacterial activity.