bluuebunny/crossref_metadata_2025_split huggingface dataset:
b‐More‐Incomplete and b‐More‐Positive: Insights on a Robust Estimator of Magnitude Distribution
Authors: Lippiello E. , Petrillo G. 
Published: February 2024

AbstractThe b‐value in earthquake magnitude‐frequency distribution quantifies the relative frequency of large versus small earthquakes. Monitoring its evolution could provide fundamental insights into temporal variations of stress on different fault patches. However, genuine b‐value changes are often difficult to distinguish from artificial ones induced by temporal variations of the detection threshold. A highly innovative and effective solution to this issue has recently been proposed by van der Elst (2021, https://doi.org/10.1029/2020jb021027) by means of the b‐positive estimator, which is based on analyzing only the positive differences in magnitude between successive earthquakes. Here, we demonstrate the robustness of the estimator, which remains largely unaffected by detection issues due to the properties of conditional probability. We illustrate that this robustness can be further improved by considering positive differences in magnitude, not only between successive earthquakes but also between different pairs of earthquakes. This generalized approach, defined as the “b‐more‐positive estimator,” enhances efficiency by providing a precise estimate of the b‐value while including a larger number of earthquakes from an incomplete catalog. However, our analysis reveals that the accuracy of the b estimators diminishes when earthquakes below the completeness threshold are included in the catalog. This leads to the paradoxical observation that greater efficiency is achieved when the catalog is more incomplete. To address this, we introduce the “b‐more‐incomplete estimator,” where the b‐more‐positive estimator is applied only after artificially filtering the instrumental catalog to make it more incomplete. Our findings show the superior efficiency of the b‐more‐incomplete method.
Sources and Distribution of Light NMHCs in the Marine Boundary Layer of the Northern Indian Ocean During Winter: Implications to Aerosol Formation
Authors: Tripathi Nidhi , Girach Imran A. , Kompalli Sobhan Kumar , Murari Vishnu , Nair Prabha R. , Babu S. Suresh , Sahu Lokesh Kumar 
Published: February 2024

AbstractNon‐methane hydrocarbons (NMHCs) are ubiquitous trace gases and profoundly affect the Earth's atmosphere and climate change. Mixing ratios of light NMHCs were measured over the northern Indian Ocean during winter‐2018 as part of the Integrated Campaign for Aerosols, gases, and Radiation Budget (ICARB‐2018). Higher levels of NMHCs over the coastal regions were due to the efficient transport of anthropogenic and biogenic air masses and higher air‐sea exchanges due to the higher biological productivity. Although oceanic emissions dominated the open ocean, the transport of aged continental air also influenced the levels of some NMHCs. The higher and lower propane/ethane ratios of 2.41 ± 0.34 and 1.13 ± 0.78 ppbv ppbv−1 over coastal and open oceans indicated the prevalence of fresh and aged air masses, respectively. Ethene and propene show a strong correlation, but the ethene/propene ratios over open ocean (2.2 ± 0.25 ppbv ppbv−1) were slightly lower than the coastal region (2.5 ± 0.34 ppbv ppbv−1). Principal component analysis reveals the major associated sources identified in this study are from oceanic and nearby anthropogenic sources, explaining nearly 51% and 21% of variance. Light alkenes accounted for ∼70% of the total ozone and secondary organic aerosol formation potential. A higher alkene/alkane ratio, strong correlation of alkene with organic aerosol mass, and new particle formation events highlight the role of alkenes in secondary aerosol formation over the equatorial Indian Ocean. Overall, the levels of NMHCs were much higher than those measured nearly two decades ago during the Indian Ocean Experiment (INDOEX)‐1999.
Impaired striatal glutamate/GABA regulation in violent offenders with antisocial personality disorder and psychopathy
Authors: Tully John , Pereira Andreia C. , Sethi Arjun , Griem Julia , Cross Ben , Williams Steve CR , Blair Robert James , Murphy Declan , Blackwood Nigel 
Published: February 2024

AbstractMen with antisocial personality disorder (ASPD) with or without psychopathy (+/−P) are responsible for most violent crime in society. Development of effective treatments is hindered by poor understanding of the neurochemical underpinnings of the condition. Men with ASPD with and without psychopathy demonstrate impulsive decision-making, associated with striatal abnormalities in functional neuroimaging studies. However, to date, no study has directly examined the potential neurochemical underpinnings of such abnormalities. We therefore investigated striatal glutamate: GABA ratio using Magnetic Resonance Spectroscopy in 30 violent offenders (16 ASPD-P, 14 ASPD + P) and 21 healthy non-offenders. Men with ASPD +/− P had a significant reduction in striatal glutamate : GABA ratio compared to non-offenders. We report, for the first time, striatal Glutamate/GABA dysregulation in ASPD +/− P, and discuss how this may be related to core behavioral abnormalities in the disorders.
Converting an allocentric goal into an egocentric steering signal
Authors: Mussells Pires Peter , Zhang Lingwei , Parache Victoria , Abbott L. F. , Maimon Gaby 
Published: February 2024

AbstractNeuronal signals that are relevant for spatial navigation have been described in many species1–10. However, a circuit-level understanding of how such signals interact to guide navigational behaviour is lacking. Here we characterize a neuronal circuit in the Drosophila central complex that compares internally generated estimates of the heading and goal angles of the fly—both of which are encoded in world-centred (allocentric) coordinates—to generate a body-centred (egocentric) steering signal. Past work has suggested that the activity of EPG neurons represents the fly’s moment-to-moment angular orientation, or heading angle, during navigation2,11. An animal’s moment-to-moment heading angle, however, is not always aligned with its goal angle—that is, the allocentric direction in which it wishes to progress forward. We describe FC2 cells12, a second set of neurons in the Drosophila brain with activity that correlates with the fly’s goal angle. Focal optogenetic activation of FC2 neurons induces flies to orient along experimenter-defined directions as they walk forward. EPG and FC2 neurons connect monosynaptically to a third neuronal class, PFL3 cells12,13. We found that individual PFL3 cells show conjunctive, spike-rate tuning to both the heading angle and the goal angle during goal-directed navigation. Informed by the anatomy and physiology of these three cell classes, we develop a model that explains how this circuit compares allocentric heading and goal angles to build an egocentric steering signal in the PFL3 output terminals. Quantitative analyses and optogenetic manipulations of PFL3 activity support the model. Finally, using a new navigational memory task, we show that flies expressing disruptors of synaptic transmission in subsets of PFL3 cells have a reduced ability to orient along arbitrary goal directions, with an effect size in quantitative accordance with the prediction of our model. The biological circuit described here reveals how two population-level allocentric signals are compared in the brain to produce an egocentric output signal that is appropriate for motor control.
Light-driven nanoscale vectorial currents
Authors: Pettine Jacob , Padmanabhan Prashant , Shi Teng , Gingras Lauren , McClintock Luke , Chang Chun-Chieh , Kwock Kevin W. C. , Yuan Long , Huang Yue , Nogan John , Baldwin Jon K. , Adel Peter , Holzwarth Ronald , Azad Abul K. , Ronning Filip , Taylor Antoinette J. , Prasankumar Rohit P. , Lin Shi-Zeng , Chen Hou-Tong 
Published: February 2024

AbstractControlled charge flows are fundamental to many areas of science and technology, serving as carriers of energy and information, as probes of material properties and dynamics1 and as a means of revealing2,3 or even inducing4,5 broken symmetries. Emerging methods for light-based current control5–16 offer particularly promising routes beyond the speed and adaptability limitations of conventional voltage-driven systems. However, optical generation and manipulation of currents at nanometre spatial scales remains a basic challenge and a crucial step towards scalable optoelectronic systems for microelectronics and information science. Here we introduce vectorial optoelectronic metasurfaces in which ultrafast light pulses induce local directional charge flows around symmetry-broken plasmonic nanostructures, with tunable responses and arbitrary patterning down to subdiffractive nanometre scales. Local symmetries and vectorial currents are revealed by polarization-dependent and wavelength-sensitive electrical readout and terahertz (THz) emission, whereas spatially tailored global currents are demonstrated in the direct generation of elusive broadband THz vector beams17. We show that, in graphene, a detailed interplay between electrodynamic, thermodynamic and hydrodynamic degrees of freedom gives rise to rapidly evolving nanoscale driving forces and charge flows under the extremely spatially and temporally localized excitation. These results set the stage for versatile patterning and optical control over nanoscale currents in materials diagnostics, THz spectroscopies, nanomagnetism and ultrafast information processing.
Successful xenotransplantation of testicular cells following fractionated chemotherapy of recipient birds
Authors: Blank Marcel Henrique , Kawaoku Allison Jun Taguchi , Rui Bruno Rogério , Carreira Ana Claudia Oliveira , Hamilton Thais Rose dos Santos , Goissis Marcelo Demarchi , Pereira Ricardo José Garcia 
Published: February 2024

AbstractAn essential step in the success of germ cell transplantation is the preparation of the recipient’s testicular environment to increase the availability of stem cell niches. However, most methods for this purpose in birds face serious limitations such as partial germ cell depletion, high toxicity and mortality, or the need to use expensive technologies. Here, we validated a simple and practical technique of transferring quail testicular cells into chicken testes depleted of endogenous spermatozoa by fractioned chemotherapy (20 mg/kg/week busulfan for 5 weeks). This protocol resulted in a very low mortality of the treated day-old chicks and, despite maintenance of androgenic activity, sperm production was decreased by 84.3% at 25 weeks of age. NANOG immunostaining revealed that very few to no germ cells were present following treatment with 20 and 40 mg/kg, respectively. RT-qPCR data also showed that c-MYC and NANOG expression declined in these treatments, but GRFα1 and BID expressions remained unaltered among groups. After xenotransplantation, quail germ cells were immunodetected in chicken testes using a species-specific antibody (QCPN), and quail ovalbumin DNA was found in seminal samples collected from chicken recipients. Together, these data confirm that fractionated administration of busulfan in hatchlings is a practical, effective, and safe protocol to prepare recipient male birds capable of supporting xenogeneic spermatogenesis.
Psychedelics and sexual functioning: a mixed-methods study
Authors: Barba Tommaso , Kettner Hannes , Radu Caterina , Peill Joseph M. , Roseman Leor , Nutt David J. , Erritzoe David , Carhart-Harris Robin , Giribaldi Bruna 
Published: February 2024

AbstractDo psychedelics affect sexual functioning postacutely? Anecdotal and qualitative evidence suggests they do, but this has never been formally tested. While sexual functioning and satisfaction are generally regarded as an important aspect of human wellbeing, sexual dysfunction is a common symptom of mental health disorders. It is also a common side effect of selective serotonin reuptake inhibitors (SSRIs), a first line treatment for depression. The aim of the present paper was to investigate the post-acute effects of psychedelics on self-reported sexual functioning, combining data from two independent studies, one large and naturalistic and the other a smaller but controlled clinical trial. Naturalistic use of psychedelics was associated with improvements in several facets of sexual functioning and satisfaction, including improved pleasure and communication during sex, satisfaction with one’s partner and physical appearance. Convergent results were found in a controlled trial of psilocybin therapy versus an SSRI, escitalopram, for depression. In this trial, patients treated with psilocybin reported positive changes in sexual functioning after treatment, while patients treated with escitalopram did not. Despite focusing on different populations and settings, this is the first research study to quantitively investigate the effects of psychedelics on sexual functioning. Results imply a potential positive effect on post-acute sexual functioning and highlight the need for more research on this.
Movements and spatial distribution of an endangered fish (Sciaena umbra) within a marine protected area
Authors: Marques R. , Brazo A. , Aspillaga E. , Zimmermann M. , Hereu B. , Saragoni G. , Mercière A. , Crec’Hriou R. , Mercader M. , Verdoit-Jarraya M. , Cadène F. , Lenfant Philippe 
Published: February 2024

AbstractThe brown meagre (Sciaena umbra) is an endangered species, which requires specific protection measures to ensure its conservation. These measures need to be informed by high-quality scientific knowledge on their space use patterns. Here, we used acoustic telemetry to assess its seasonal movement patterns and habitat use within a marine protected area (MPA). Our results suggested that S. umbra is a highly sedentary species (home range < 1.0 km2) and, therefore, the MPA is extensive enough to protect the local population. Their population was discretely distributed in two main areas within the MPA, which was likely a result of habitat segregation and density-dependent movements. The temporal variability of their movements further uncovered when and where spawning occurs (mainly, but probably not only, in the fully protected area in June) and indicated that spillover of this species is limited but still possible. Overall, we highlight the importance of MPAs in the recovery of S. umbra, we advocate the need to perpetuate the current national fishing bans and extend it to other countries in the Mediterranean region, and we emphasize that considering the fine-scale movements of S. umbra in future management actions is key to achieving a successful recovery of their populations.
Investigating the impact of Wnt pathway-related genes on biomarker and diagnostic model development for osteoporosis in postmenopausal females
Authors: Lai Jinzhi , Yang Hainan , Huang Jingshan , He Lijiang 
Published: February 2024

AbstractThe Wnt signaling pathway is essential for bone development and maintaining skeletal homeostasis, making it particularly relevant in osteoporosis patients. Our study aimed to identify distinct molecular clusters associated with the Wnt pathway and develop a diagnostic model for osteoporosis in postmenopausal Caucasian women. We downloaded three datasets (GSE56814, GSE56815 and GSE2208) related to osteoporosis from the GEO database. Our analysis identified a total of 371 differentially expressed genes (DEGs) between low and high bone mineral density (BMD) groups, with 12 genes associated with the Wnt signaling pathway, referred to as osteoporosis-associated Wnt pathway-related genes. Employing four independent machine learning models, we established a diagnostic model using the 12 osteoporosis-associated Wnt pathway-related genes in the training set. The XGB model showed the most promising discriminative potential. We further validate the predictive capability of our diagnostic model by applying it to three external datasets specifically related to osteoporosis. Subsequently, we constructed a diagnostic nomogram based on the five crucial genes identified from the XGB model. In addition, through the utilization of DGIdb, we identified a total of 30 molecular compounds or medications that exhibit potential as promising therapeutic targets for osteoporosis. In summary, our comprehensive analysis provides valuable insights into the relationship between the osteoporosis and Wnt signaling pathway.
Investigating the individual and combined effects of coenzyme Q10 and vitamin C on CLP-induced cardiac injury in rats
Authors: Üstündağ Hilal , Demir Özlem , Huyut Mehmet Tahir , Yüce Neslihan 
Published: February 2024

AbstractSepsis-induced cardiac injury represents a major clinical challenge, amplifying the urgency for effective therapeutic interventions. This study aimed to delve into the individual and combined prophylactic effects of Vitamin C (Vit C) and Coenzyme Q10 (CoQ10) against inflammatory heart injury in a cecal ligation and puncture (CLP) induced polymicrobial sepsis rat model. Thirty adult female Sprague–Dawley rats were randomly divided into five groups: Control, CLP, Vitamin C, CoQ10, and Vit C + CoQ10, each consisting of six rats. Treatments were administered orally via gavage for 10 days prior to the operation. Eighteen hours post-sepsis induction, the animals were euthanized, and specimens were collected for analysis. The study examined variations in oxidative (TOS, OSI, MDA, MPO) and antioxidative markers (TAS, SOD, CAT, GSH), histopathological changes, inflammatory cytokine concentrations (TNF-α, IL-1β), nitric oxide (NO) dynamics, and cardiac indicators such as CK-MB. Impressively, the combined regimen markedly diminished oxidative stress, and antioxidative parameters reflected notable enhancements. Elevated NO levels, a central player in sepsis-driven inflammatory cascades, were effectively tempered by our intervention. Histological examinations corroborated the biochemical data, revealing diminished cardiac tissue damage in treated subjects. Furthermore, a marked suppression in pro-inflammatory cytokines was discerned, solidifying the therapeutic potential of our intervention. Interestingly, in certain evaluations, CoQ10 exhibited superior benefits over Vit C. Collectively, these findings underscore the potential therapeutic promise of Vit C and CoQ10 combination against septic cardiac injuries in rats.
Activated FGFR2 signalling as a biomarker for selection of intrahepatic cholangiocarcinoma patients candidate to FGFR targeted therapies
Authors: Brandi Giovanni , Relli Valeria , Deserti Marzia , Palloni Andrea , Indio Valentina , Astolfi Annalisa , Serravalle Salvatore , Mattiaccio Alessandro , Vasuri Francesco , Malvi Deborah , Deiana Chiara , Pantaleo Maria Abbondanza , Cescon Matteo , Rizzo Alessandro , Katoh Masaru , Tavolari Simona 
Published: February 2024

AbstractFGFR inhibitors have been developed to inhibit FGFR activation and signal transduction; notwithstanding, currently the selection of intrahepatic cholangiocarcinoma (iCCA) patients for these drugs only relies on the detection of FGFR2 genetic alterations (GAs) in tumor tissues or circulating tumor DNAs, without concomitant assessment of FGFR2 signalling status. Accordingly, we performed multi-omic analyses of FGFR2 genes and FGFR2 signalling molecules in the tissue samples from 36 iCCA naïve patients. Gain-of-function FGFR2 GAs were detected in 7 patients, including missense mutations (n = 3; p.F276C, p.C382R and p.Y375C), translocations (n = 1) and copy number gain (n = 4; CNV ≥ 4). In contrast, among 29 patients with wild-type FGFR2, 4 cases showed activation of FGFR2 signalling, as they expressed the FGFR2 ligand FGF10 and phosphorylated FGFR2/FRS2α proteins; the remaining 25 cases resulted negative for activated FGFR2 signalling, as they lacked FGFR2 (n = 8) or phosphorylated FRS2α (n = 17) expression. Overall, we found that activation of FGFR2 signalling occurs not only in iCCA naïve patients with FGFR2 GAs, but also in a subgroup carrying wild-type FGFR2. This last finding entails that also this setting of patients could benefit from FGFR targeted therapies, widening indication of these drugs for iCCA patients beyond current approval. Future clinical studies are therefore encouraged to confirm this hypothesis.
Association of dietary niacin intake with the prevalence and incidence of chronic obstructive pulmonary disease
Authors: Li Wen-Wen , Ren Kun-Lun , Yu Jia , Guo Hai-Sheng , Liu Ben-Hong , Sun Yang 
Published: February 2024

AbstractEvidence regarding the association between dietary niacin intake and chronic obstructive pulmonary disease (COPD) is limited. Our study investigates the relationship between dietary niacin intake and the prevalance and incidence of COPD in the adult population of the United States, using data from the National Health and Nutrition Examination Survey (NHANES) from 2003 to 2018. Data on niacin intake were extracted through dietary intake interviews. COPD diagnoses were based on lung function, medical history, and medication usage. We analyzed the association between niacin consumption and COPD using multiple logistic regression and restricted cubic spline models. The study included 7055 adult participants, divided into COPD (n = 243; 3.44%) and non-COPD (n = 6812; 96.56%) groups. Those with COPD had lower average niacin intake (21.39 ± 0.62 mg/day) compared to the non-COPD group (25.29 ± 0.23 mg/day, p < 0.001). In the adjusted multivariable model, the odds ratios (OR) and 95% confidence intervals (CI) for COPD in the highest versus lowest quartile of dietary niacin intake were 0.55 (0.33 to 0.89, P for trend = 0.009). Subgroup analysis, after adjustment for various variables, revealed no significant interaction effects. Dietary niacin intake was inversely associated with COPD prevalence in US adults. Participants with the highest dietary niacin intake demonstrated the lowest odds of COPD. The potential of dietary niacin supplementation as a strategy to mitigate COPD warrants further investigation.
Re-irradiation for isolated neck recurrence in head and neck tumor: impact of rN category
Authors: Yamazaki Hideya , Suzuki Gen , Aibe Norihiro , Shiomi Hiroya , Oh Ryoong-jin , Yoshida Ken , Nakamura Satoaki , Konishi Koji , Matsuyama Tomohiko , Ogita Mikio 
Published: February 2024

AbstractUnresectable, isolated lymph node recurrence after radiotherapy is rare but a candidate for re-irradiation. However, severe toxicity is anticipated. Therefore, this study aimed to explore the efficacy and toxicity of re-irradiation in isolated lymph node recurrence of head and neck lesions. We analyzed 46 patients who received re-irradiation for lymph node recurrence without local progression. The primary tumor sites included the oral cavity in 17 patients, the hypopharynx in 12, the oropharynx in seven, the larynx in three, the nasopharynx in two, and other sites. During a median follow-up time of 10 months, the median survival time was 10.6 months, and the 1-year overall survival rate was 45.5%. The 1-year local control and progression-free survival rates were 49.8% and 39.3%, respectively. According to univariate analysis, age (≥ 65 years), the interval between treatment (≥ 12 months), rN category (rN1), and gross tumor volume (GTV < 25 cm3) were predisposing factors for better survival. In the multivariate analysis, the rN category and interval were identified as statistically significant predictors. Late toxicity grade ≥ 3 occurred in four patients (8.6%). These were all Grade 5 carotid blowout syndrome, which associated with tumor invasion of the carotid artery and/ or high doses administration for the carotid artery. Small-volume rN1 tumor that recur after a longer interval is a feasible candidate for re-irradiation. However, strict patient selection and meticulous care for the carotid are required.