bluuebunny/crossref_metadata_2025_split huggingface dataset:
The influence of depression and antidepressants on driving performance: a systematic literature review and meta-analysis.
Authors: Kamphuis Kas G. , Goldenbeld Charles , Kuzminskaite Erika , Davidse Ragnhild J. , Penninx Brenda W.J.H. 
Published: October 2023

Abstract
Background
The public health impact of depression is large, as depression affects social and work functioning as well as physical health outcomes. A less explored topic is to what extent depression affects public health by impacting on road safety. To determine whether depression and antidepressant use have impact on driving safety and thereby public health, we systematically reviewed literature that examines their association with objectively assessed driving performance outcomes.
Methods
Two systematic literature reviews were performed, one for depression – driving performance (DEP-DP) and one for antidepressants – driving performance (AD-DP). Three online databases (PubMed, PsychINFO, Embase) were searched from Jan 1st 1997 through December 31st 2022. Estimates of effect sizes, Hedges’ g, were reported for standard deviation of lateral position (SDLP), speed, speed deviation, reaction time, visual perception, stress tolerance and reactivity, vigilance, sustained attention and selective attention. Meta-analyses were performed by calculating pooled estimates when at least three studies reported on the same outcome.
Results
For DEP-DP, only two studies could be included, both indicating poorer driving performance in depressed persons, but pooled estimates could not be calculated as not enough studies tested similar driving performance outcomes. For AD-DP, seven studies were included and pooled estimates could be calculated for four outcomes: reaction time, vigilance, selective attention and SDLP. AD users were less vigilant compared to healthy controls (3 studies, n=104, g=-.49, 95% CI -.85; -.13). No significant difference could be demonstrated for reaction time (3 studies, n = 93, g=.52, 95% CI -1.97; 3.00), selective attention (3 studies, n=104, g=-.45, -1.10; 0.19) or SDLP (3 studies, n=74, g=.06, 95% CI -1.15; 1.26).
Conclusions
Although various studies reported poorer driving performance in depressed persons as well as antidepressant users, a consistent picture is limited by the small number of studies and diverse driving performance outcomes used. Only a significant impact of antidepressant use on vigilance could be indicated, but as no comparison was made with depressed non-users, it is difficult to interpret such findings. More research is needed into the separate effects of depression and antidepressants on objectively assessed driving performance.
Preparation of Co3O4 nanoparticles in a lyotropic liquid crystal medium and their application in anti-bacterial, anti-cancer and catalytic activities
Authors: Santhiya N. , Meyyathal PR. , Umadevi S. 
Published: October 2023

Abstract
Preparation of Co3O4 nanoparticles (NPs) via a chemical reduction method at room temperature in a lyotropic liquid crystal (LLC) medium is described. A mixture of triton X-100 and water in the ratio 2.1:2.9 (wt%) exhibited LLC having a hexagonal structure in the temperature range 25-29°C. The NPs were prepared in this medium by reducing cobalt(II) chloride hexahydrate (CoCl2.6H2O) using sodium borohydride (NaBH4) resulting in nearly spherical particles having a size of ∼100nm. The LLC medium facilitated a controlled growth of the NPs and also provided stabilization for the NPs by preventing their aggregation. The anti-bacterial activity of the particles indicated a significant activity towards gram-negative bacteria. Anticancer activity against breast cancer cell line MCF-7 showed an impressive IC50 value of 30.8 µg/mL. Additionally, the efficiency of the Co3O4 NPs as catalyst for the reduction of 4-nitrophenol and degradation of a dye named methylene blue was evaluated; the apparent rate constant values calculated for these reactions were 1.8´10-2 min-1 and 3.1´10-2 min-1 respectively. Besides, particles displayed efficient activity till 5th cycle.
The impact of UK social distancing guidance on the health and wellbeing of disabled people during the COVID-19 pandemic: a qualitative exploration
Authors: Nicholls Lucy , McKinlay Alison , Berger Rachael , Fancourt Daisy , Burton Alexandra 
Published: October 2023

Abstract
Background The sudden introduction of social distancing measures in response to the COVID-19 pandemic resulted in significant lifestyle changes for the UK population. People living with physical disabilities were deemed to be at greater risk of complications following COVID-19 infection and were subjected to stricter social distancing guidelines. But gaps remain in our understanding of how the COVID-19 pandemic and associated restrictions affected the health and wellbeing of people with physical disabilities. Such understanding is vital to ensure equitable future pandemic preparedness for people living with physical disabilities.
Methods We conducted qualitative semi-structured interviews with 31 people living in the UK between May 2020 and January 2022. All participants self-identified as having a physical disability that affected their mobility, sight, or hearing. We analysed the data using reflexive thematic analysis.
Results Six themes were identified that described the impact of the pandemic on health and wellbeing: i) adaptations to healthcare provision led to a deterioration in health; ii) exacerbations of inequalities in access to public space due to social distancing guidelines; iii) experiences of hostility from able-bodied people; iv) loss of social lives and encounters; v) difficulties maintaining distance from others and subsequent fear of infection and vi) strategies to support mental health and coping when confined to the home.
Conclusion The COVID-19 pandemic exacerbated existing health and social inequalities experienced by disabled people. The disproportionate impact of the pandemic on service provision and social connections resulted in challenging circumstances for disabled people who faced unmet medical needs, deteriorating health, and at times, hostile public spaces. Disabled people’s experiences need to be incorporated into future pandemic or health-related emergency planning to ensure equality of access to services and public spaces to ensure their health and wellbeing is supported and maintained.
Assessing Primary Health Care Provider and Organization Readiness to Address Family Violence in Alberta, Canada: Development of a Delphi Consensus Readiness Tool
Authors: Sehgal Anika , Montesanti Stephanie , Zaeem Lubna , McManus Carrie , Squires Suzanne , Silverstone Peter 
Published: October 2023

Abstract

Background Family violence, which includes intimate partner abuse, child abuse, and elder abuse, is a serious public health concern. Primary healthcare (PHC) offers a vital opportunity to identify and address family violence, yet barriers prevent the effective implementation of Family violence interventions in PHC settings. The current paper aims to enhance family violence identification and response in Alberta's PHC settings by exploring readiness factors. Methods An integrated knowledge translation approach, combining implementation science and participatory action research, was employed to develop a readiness assessment tool for addressing family violence within PHC settings in Alberta. The research involved three phases: phase 1 encompassed a realist-informed rapid evidence assessment, phase 2 engaged a panel of healthcare experts to explore readiness components in the Alberta context, and phase 3 utilized a 3-round Delphi consensus-building process to refine indicators. Results Key findings from a rapid evidence assessment highlighted five main models/tools for assessing readiness to implement family violence interventions in PHC settings. In phase 2, additional concepts were identified through exploration with healthcare expert panel members, resulting in a total of 16 concepts for assessing family violence readiness within the Alberta context. The 3-round Delphi consensus-building process involved nine panelists, who collectively agreed on the inclusion of all concepts and indicators, yielding a total of 60 items for the proposed readiness assessment tool for addressing family violence in PHC within Alberta. Conclusion The current study lays the groundwork for future family violence intervention programs, offering insights into key components that promote readiness for implementing comprehensive programs and supporting PHC organizations in effectively addressing family violence.
Use of Himplant® for Correction of Residual Deformity Following Prior Treatment of Peyronie’s Disease: A Case Series
Authors: Elist James , Levine Laurence , Desouky Elsayed , Moon Daniel , Wilson Steven 
Published: October 2023

Abstract
Over the years, numerous non-surgical and surgical treatment options have been explored for Peyronie’s disease (PD). Current options may result in incomplete correction of the deformity, which can be bothersome to the patient. This is a two-center case series of three patients who had previously undergone treatment for PD. Patient data was collected, including demographics, PD characteristics, previous treatments, and outcomes. Patient 1 underwent plication with extratunical grafting. Patient 2 underwent a series of Xiaflex injections and then subsequent plication for residual curvature. Patient 3 underwent a series of Xiaflex injections. The Himplant® subcutaneous silicone penile prosthesis was placed in a standardized manner in all cases. Follow-up evaluation was conducted to assess the effectiveness and patient satisfaction following the Himplant® procedure and to report on associated complications. Our case series demonstrates the potential effectiveness and benefits of using Himplant® to correct residual penile deformity and enhance penile girth in patients after PD treatment. Based on our limited experience, we would consider offering Himplant® implantation when the residual curvature is < 40° and the penile indentation does not cause instability/buckling during penetrative sexual activity. Further research and larger studies are warranted to validate these findings and assess long-term outcomes and patient-reported satisfaction.
Environmental innovation and international migration of inventors
Authors: Etzo Ivan , Takaoka Sumiko 
Published: October 2023

Abstract
We study the effects of migrant inventors on environmental innovation activity for sustainable development. We focus on the migration of inventors from (to) countries that specialize in patent applications grouped into eight environment-related technology domains. Using the novel dataset created by Pellegrino et al. (2023) and a weighting scheme to construct the migrant inventor variables, we create accurate measures of the stock of immigrant and emigrant inventors. We find a positive and significant impact of migrant inventors on the green innovation activity of both receiving and sending countries. The results indicate that environmental innovation rises with R&D expenditure, international trade, air pollution (CO2 emissions), and the number of natural disasters. Our results are robust to the instrumental variable approach, a falsification test for the main explanatory variables, a dynamic model specification (path dependency hypothesis), a different set of lagged control variables, and inventors’ data tracked over time.
Relationship Between Helicobacter Pylori Infection and Chronic Respiratory Disease: A Two-sample Mendelian Randomization Study
Authors: Jia Guobing , Guo Tao , He Chengshi 
Published: October 2023

Abstract
Background
Although many studies have found an association between Helicobacter pylori (H. pylori) infection and chronic respiratory disease, the conclusions are not uniform across studies and the exact relationship remains unclear.
Methods
We explored the bidirectional causal relationship between H. pylori infection and chronic respiratory disease using a two-sample Mendelian Randomization (MR) method. Data on exposure and outcomes were obtained from the publicly available genome-wide association study (GWAS) database, data on H. pylori infection were obtained from the European Bioinformatics Institute (EBI) database, while chronic respiratory disease from the FinnGen database. The inverse variance weighting (IVW) was used as the primary statistical method.
Results
MR analyses showed that genetically predicted H. pylori infection had no effect on any of the five chronic respiratory diseases under the Wald ratio and IVW methods. The three MR methods, IVW, MR-Egger, and weighted median (WM), showed that H. pylori infection did not have an effect on any of the four chronic respiratory diseases (asthma, chronic obstructive pulmonary disease (COPD), lung cancer, and bronchiectasis). The IVW method showed that idiopathic pulmonary fibrosis (IPF) was associated with a H. pylori infection risk reduction (OR = 0.97; p = 0.041), which was not significant using the MR-Egger and WM methods.
Conclusion
Our results found that H. pylori infection had no effect on chronic respiratory diseases, and asthma, COPD, lung cancer, and bronchiectasis have no effect on H. pylori infection, whereas IPF has a mild protective effect against H. pylori infection.
Chronic Pain Healthcare workers’ challenges in pain management and receptiveness towards VR as an adjunct management tool: a qualitative study
Authors: Li Lydia Weiling , Tan Hui Yi , Khaing Nang Ei Ei 
Published: October 2023

Abstract
Background
Chronic pain is a debilitating condition that affects individuals physically and mentally. Reliance on pharmacotherapy for pain management comes with risks of analgesic misuse and dependence. Hence, non-pharmacologic treatment plays a crucial role in pain management. Virtual reality is a novel method in chronic pain management. However, there is little understanding about healthcare providers’ perspectives on the use of virtual reality technology in managing chronic pain. This study aims to explore the current management challenges faced by chronic pain healthcare providers and their perspectives on using virtual reality as adjunctive therapy in managing chronic pain.
Method
Individual semi-structured interviews were conducted among all chronic pain healthcare providers in a tertiary hospital. The interviews were analysed using qualitative thematic analysis.
Results
Eight chronic pain healthcare providers participated in this study. Financial issues were cited as one of the biggest barriers for utilisation of non-pharmacological treatment. Participants highlighted the importance of psychosocial support from family and healthcare providers. Challenges identified included absence of patient engagement and lack of awareness about pain management among healthcare providers as well as the lack of an integrated multidisciplinary approach in our healthcare system. Participants were receptive towards the use of virtual reality in chronic pain management and offered ample opinions and suggestions for its application in chronic pain management.
Conclusions
A multilevel, multifaceted approach is needed to improve chronic pain management. Virtual reality technology could be considered as an adjunct therapy to address some of the challenges and limitations identified in this study.
Identification of Key Genes and Pathways Governing T-DM1 Resistance in OE-19 Esophageal Cancer Cells through Bioinformatics Analysis
Authors: Yazdani Fateme , Mottaghi-Dastjerdi Negar , Ghorbani Abozar , Soltany-Rezaee-Rad Mohammad , Montazeri Hamed , Khoshdel Farzane , Guzzi Pietro Hiram 
Published: October 2023

Abstract
Introduction
: Esophageal Cancer (EC) ranks among the most common malignancies worldwide. Most EC patients acquire drug resistance to chemotherapy either intrinsically or acquired after T-DM1 treatment, which shows that increasing or decreasing the expression of particular genes might influence chemotherapeutic sensitivity or resistance. Therefore, gaining a deeper understanding of the altered expression of genes involved in EC drug resistance and developing new therapeutic methods are essential targets for continued advancement in EC therapy.
Methods
The present study aimed to find critical regulatory genes/pathways in the progression of T-DM1 resistance in OE-19 EC cells. Expression datasets were extracted from GEO omnibus. Gene interactions were analyzed, and the protein-protein interaction network was drawn. Then, enrichment analysis of the hub genes and network cluster analysis of the hub genes was performed. Finally, the genes were screened in the DrugBank database as therapeutic targets.
Results
In the current study nine hub genes were identified in TDM-1 resistant EC cells (CTGF, CDH17, THBS1, CXCL8, NRP1, ITGB5, EDN1, FAT1, and PTGS2). the KEGG analysis highlighted the IL-17 signaling pathway and ECM-receptor interaction pathway as the most important pathways; cluster analysis also showed the significance of these pathways; therefore, the genes involved in these two pathways, including CXCL8, FSCN1, PTGS2, SERPINE2, LEF1, THBS1, CCN2, TAGLN, CDH11, ITGA6 were searched in DrugBank as therapeutic targets. The DrugBank analysis suggests a potential role for Nonsteroidal Anti-Inflammatory Drugs (NSAIDs) in reducing T-DM1 drug resistance in EC.
Conclusion
This comprehensive bioinformatics analysis deeply explains the molecular mechanisms governing TDM-1 resistance in EC. The identified hub genes and their associated pathways offer potential targets for therapeutic interventions. Moreover, the potential role of NSAIDs in mitigating T-DM1 resistance presents an intriguing avenue for further investigation. This research contributes significantly to the field and establishes a basis for further research to enhance treatment efficacy for EC patients.
A Study of the Effects of Learning and Practicing Motor Skills on Cognitive Abilities and Psychological Well-being Among Older Adults with Mild Cognitive Impairment
Authors: Javanmard Gholam Hossein , Javanmard Shahin 
Published: October 2023

Abstract
Background
Older adults' mild cognitive impairment (MCI) can affect their daily activities. Therefore, researchers have developed a variety of rehabilitation strategies for this impairment. This study examines the impact of learning and practicing motor skills on the cognitive functioning and psychological well-being of patients suspected of being affected by MCI.
Method
For this purpose, 32 patients aged 55-75-year-old men were selected among people suspected of having MCI syndrome by interviewing and psychological evaluation by a psychologist and randomly divided into two experimental and control groups. Nejati cognitive ability tests (2013) (which evaluates seven cognitive abilities: memory, inhibitory control and selective attention, decision making, planning, sustained attention, social cognition, and cognitive flexibility) and the Oxford Happiness Questionnaire (1989) (which evaluates five psychological well-being factors; life satisfaction, happiness, self-esteem, self-control, and self-efficacy) was implemented on the groups. Three months and three weekly sessions were organized for the experimental group, in which movement skills (adapted from authentic martial arts) were taught and practiced. The multivariate covariance analysis (MANCOVA) statistical method analyzed the pre-and post-test data.
Conclusion
The results showed that learning and practicing movement skills impacted brain functioning, improving several cognitive abilities and aspects of psychological well-being in older adults who were believed to suffer from MCI syndrome. Furthermore, from a theoretical standpoint, these findings are consistent with the results of neuroscience and specific theories that see cognition as a type of movement-dependent brain functioning.
Whole Exome Sequencing on a multiplex family of Indian origin identifies mutations at 17p11.2 in siblings with autism spectrum disorders: implications to understanding the pathophysiology from syndromic variants.
Authors: Srivid Durbagula , Ranganayaki Sathyanarayanan , Parambath Snijesh Valiya , S Aparna H , Korlimarla Aruna , Prabhakaran Nishant , Vijayanand Meghana , Gowda Naveen Kumar C 
Published: October 2023

Abstract
Autism Spectrum Disorders (ASDs) is a complex neurodevelopmental disorder characterized by restrictive repetitive behaviour and impairment in social and communication skills. It is extremely heterogeneous with a strong genetic preponderance. It’s clinically highly convoluted, represented with multiple comorbid conditions and syndromic features. More than 100 genes have been identified till date that are associated with syndromic ASDs. Whole exome sequencing (WES) has emerged as a valuable tool in evaluating the genetic underpinnings of ASDs, be it the syndromic or the idiopathic variants. The current study leverages the utility of WES in a multiplex family of Indian origin to identify the disease etiology in the siblings (01S1 (Female) and 01S2 (Male)) exhibiting ASD syndromic features, at both clinical and molecular levels. Our systematic bioinformatic analysis identified a missense mutation (NM_030665.4:c.5320C > T; p.Arg1774Trp) in 01S1 resulting in RAI1 haploinsufficiency. Validation by sanger sequencing confirmed the novelty of the said mutation and that it was true positive and maternally transmitted in the subject. Likewise, we report a missense mutation at the same locus (17p11.2) corresponding to the FLII gene (NM_002018.4:c.2030A > C;p.Glu677Ala) in the other sibling, 01S2. Both the mutations were reported in the Smith Magenis Syndrome (SMS) critical region justifying its contribution to the presentation of the syndromic SMS features. These WES findings were consistent with the clinical findings that imply SMS features in both siblings. The current study employs WES to provide insights into the complex molecular mechanism associated with syndromic ASD highlighting the different processes that contribute to the disease heterogeneity. Moving forward, combinatorial approaches and findings from syndromic ASDs can potentially act as indicators to understand the genetic and phenotypic variations seen in the idiopathic ASD.
Synthesis and studies on some cholesterol containing poly-siloxane based side- chain liquid crystal elastomers
Authors: Mohana K. , Deepa M. , Umadevi S. 
Published: October 2023

Abstract
Siloxane-based side-chain liquid crystal elastomers (SCLCEs) containing cholesteryl 4-(undec-10-en-1-yloxy)benzoate mesogenic unit are described. The cholesteric mesogen was dimesomorphic and displayed a smectic A and nematic phases having a phase range of 69°C and 32°C respectively. Four elastomers (polydomain powders) were synthesized by employing the LC mesogen, polymethylhydrosiloxane (PMHS) backbone and four different cross-linkers (alkyl, phenyl, biphenyl and azo) through hydrosilylation reaction. All the elastomers were found to be stable up to 300°C and exhibited an intercalated lamellar structure. Among the four elastomers studied, a wide phase range was observed for LCE4 with an azo cross-linker and the LCE1 containing an alkyl cross-linker exhibited a low phase range. The photoisomerization of the LCE4 (due to the presence of azo- group) was investigated in toluene and photostationary state for trans-to-cis conversion was observed at 150 s. The polymeric films of the elastomers were also prepared. A noticeable bending response was was observed for a thermal stimulus in elastomers containing alkyl, phenyl and azo cross-linkers which was more pronounced in LCE4 having azo cross-linker.