bluuebunny/crossref_metadata_2025_split huggingface dataset:
Budesonide/formoterol maintenance and reliever therapy in childhood asthma: Real‐world effectiveness and economic assessment
Authors: Yu Yuncui , Cao Wang , Xiao Yue , Li Ang , Huang Huijie , Liu Kejun , Hu Lihua , Hou Xiaoling , Xiang Li , Wang Xiaoling 
Published: October 2023

AbstractIntroductionThe study aims to compare the real‐world effectiveness and economy of the budesonide/formoterol reliever and maintenance therapy (SMART) with fixed‐dose inhaled corticosteroids (ICS)/long‐acting b‐agonist (LABA) or ICS alone plus as‐needed, short‐acting β2 agonists (SABA) in pediatric patients.MethodsThe outpatient data warehouse of a hospital in China was used. A total of 103 patients under 18 years old in the SMART group and 63 patients in the control group were included from January 1, 2020 to December 31, 2021. The effectiveness was assessed using asthma attacks and lung function at baseline, 6 months and 12 months follow‐up. Cost‐effectiveness analysis was performed with a three‐state Markov model from the healthcare system perspective. One‐way sensitivity analyses and probabilistic sensitivity analyses were performed to check the robustness of the results.ResultsThe SMART regimen was more effective than other strategies in reducing the risk of mild and severe attacks in the real‐life management of childhood asthma. Patients in both groups showed significant improvement in lung function at 6 and 12 months in contrast to baseline. Compared with other strategies, the forced expiratory volume in 1 s (FEV1) level in the SMART group was markedly improved at 6 months. The total cost of outpatient service using the SMART regimen was lower than that of other strategies, while the drug costs were similar in different groups. Incremental cost‐effectiveness analysis results showed that using the SMART regimen reduced the total cost by approximately CNY 10,516.11 per year with a 0.12 quality‐adjusted life year (QALYs) increase. Sensitive analyses supported that the SMART regimen was the dominant choice at the willingness‐to‐pay threshold of CNY 85,698, per capita GDP in China.ConclusionsCollectively, our findings indicate that the real‐world effectiveness and economy of the SMART regimen are superior to the traditional strategies in pediatric asthma patients.
TP53 structure–function relationships in metastatic castrate‐sensitive prostate cancer and the impact of APR‐246 treatment
Authors: Hoang Tung , Sutera Philip , Nguyen Triet , Chang Jinhee , Jagtap Shreya , Song Yang , Shetty Amol C. , Chowdhury Dipanwita D. , Chan Aaron , Carrieri Francesca A. , Hathout Lara , Ennis Ronald , Jabbour Salma K. , Parikh Rahul , Molitoris Jason , Song Daniel Y. , DeWeese Theodore , Marchionni Luigi , Ren Lei , Sawant Amit , Simone Nicole , Lafargue Audrey , Van Der Eecken Kim , Bunz Fred , Ost Piet , Tran Phuoc T. , Deek Matthew P. 
Published: October 2023

AbstractPurposeDespite well‐informed work in several malignancies, the phenotypic effects of TP53 mutations in metastatic castration‐sensitive prostate cancer (mCSPC) progression and metastasis are not clear. We characterized the structure–function and clinical impact of TP53 mutations in mCSPC.Patients and MethodsWe performed an international retrospective review of men with mCSPC who underwent next‐generation sequencing and were stratified according to TP53 mutational status and metastatic burden. Clinical outcomes included radiographic progression‐free survival (rPFS) and overall survival (OS) evaluated with Kaplan–Meier and multivariable Cox regression. We also utilized isogenic cancer cell lines to assess the effect of TP53 mutations and APR‐246 treatment on migration, invasion, colony formation in vitro, and tumor growth in vivo. Preclinical experimental observations were compared using t‐tests and ANOVA.ResultsDominant‐negative (DN) TP53 mutations were enriched in patients with synchronous (vs. metachronous) (20.7% vs. 6.3%, p < 0.01) and polymetastatic (vs. oligometastatic) (14.4% vs. 7.9%, p < 0.01) disease. On multivariable analysis, DN mutations were associated with worse rPFS (hazards ratio [HR] = 1.97, 95% confidence interval [CI]: 1.31–2.98) and overall survival [OS] (HR = 2.05, 95% CI: 1.14–3.68) compared to TP53 wild type (WT). In vitro, 22Rv1 TP53 R175H cells possessed stronger migration, invasion, colony formation ability, and cellular movement pathway enrichment in RNA sequencing analysis compared to 22Rv1 TP53 WT cells. Treatment with APR‐246 reversed the effects of TP53 mutations in vitro and inhibited 22Rv1 TP53 R175H tumor growth in vivo in a dosage‐dependent manner.ConclusionsDN TP53 mutations correlated with worse prognosis in prostate cancer patients and higher metastatic potential, which could be counteracted by APR‐246 treatment suggesting a potential future therapeutic avenue.
Therapeutic considerations of bioactive compounds in Alzheimer's disease and Parkinson's disease: Dissecting the molecular pathways
Authors: Phukan Banashree Chetia , Roy Rubina , Gahatraj Indira , Bhattacharya Pallab , Borah Anupom 
Published: October 2023

AbstractLeading neurodegenerative diseases Alzheimer's disease (AD) and Parkinson's disease (PD) are characterized by the impairment of memory and motor functions, respectively. Despite several breakthroughs, there exists a lack of disease‐modifying treatment strategies for these diseases, as the available drugs provide symptomatic relief and bring along side effects. Bioactive compounds are reported to bear neuroprotective properties with minimal toxicity, however, a detailed elucidation of their modes of neuroprotection is lacking. The review elucidates the neuroprotective mechanism(s) of some of the major phyto‐compounds in pre‐clinical and clinical studies of AD and PD to understand their potential in combating these diseases. Curcumin, eugenol, resveratrol, baicalein, sesamol and so on have proved efficient in countering the pathological hallmarks of AD and PD. Curcumin, resveratrol, caffeine and so on have reached the clinical phases of these diseases, while aromadendrin, delphinidin, cyanidin and xanthohumol are yet to be extensively explored in pre‐clinical phases. The review highlights the need for extensive investigation of these compounds in the clinical stages of these diseases so as to utilize their disease‐modifying abilities in the real field of treatment. Moreover, poor pharmacokinetic properties of natural compounds are constraints to their therapeutic yields and this review suggests a plausible contribution of nanotechnology in overcoming these limitations.
Current landscape of climate change adaptation and health preparedness among indigenous populations in Southeast Asia
Authors: Ramazanu Sheena , Wiyono Lowilius , Abu‐Odah Hammoda , Comabig Rey G. , Musa Shuaibu Saidu , Mahmood Jemilah , Goh Yong Zhin , Hussain Nurul Amanina Binte , Rajasegaran Siddharthen , Skanthakumar Thakshayeni , Miranda Adriana Viola 
Published: October 2023

AbstractHuman‐induced climate change poses a pervasive threat to the world. Human activities, such as deforestation, farming livestock, and burning fossil fuels, are key drivers of climate change. Like other regions, the Southeast Asian region is greatly impacted by climate change. The article focuses on examining the current landscape of climate change adaptation and health preparedness among indigenous populations in Southeast Asia (SEA). Climate change will affect the indigenous populations disproportionately. Over the years, indigenous people living in SEA have faced increasing challenges. For instance, air pollution resulting from forest fires causes respiratory conditions, skin irritations, and other significant health risks. The article also highlights climate change–related health system preparedness in ASEAN and indigenous strategies in navigating climate change adaption. As the saying goes, “actions speak louder than words.” To develop sustainable regional climate change adaptation strategies, representation and voices of indigenous peoples matter. At ASEAN level, although the ASEAN Working Group on Climate Change was convened to develop policies and coordinate action plans among its member states, it is now key to include and learn from the instrumental strategies of indigenous communities in conserving, protecting, and restoring forests. Beyond acknowledging the efforts of indigenous communities on paper, it is now time to translate scientific knowledge into practical actions. It is necessary for us to value and recognize indigenous peoples, particularly in SEA as valued agents in co‐creating sustainable solutions for climate agenda. Centering indigenous peoples’ knowledge in climate adaptation is crucial for strengthening collective resilience in climate action strategies. Conclusively, the article advocates for the prioritization of indigenous communities’ leadership efforts in ASEAN‐wide climate action initiatives and climate action policy.
Topological indices and QSPR analysis of some chemical structures applied for the treatment of heart patients
Authors: Hasani Mehri , Ghods Masoud 
Published: October 2023

AbstractIn this study, various beta‐blocker drugs used for heart disease were analyzed, and their degree‐based topological indices derived from the M‐polynomial were calculated. Linear and quadratic regression analysis was used to obtain quantitative structure‐property relationship models between the topological indices and eight the physicochemical properties of the drugs to determine their effectiveness. The results show that the harmonic index was the best predictor for boiling point, flashpoint, and enthalpy of vaporization, while the redefined third Zagreb index was effective for polarizability, molar refractivity, and molar volume. The inverse sum indeg index was found to be effective for molar refractivity, and the second modified Zagreb index was surface tension in linear regression models. In addition, the redefined third Zagreb index was the best predictor for polarizability and molar refractivity, while the second modified Zagreb index was effective for molar volume. The SDD index was found to be effective for surface tension in quadratic regression models.
Multicolor Continuous‐Variable Quantum Entanglement in the Kerr Frequency Comb
Authors: Li Ming , Zhang Yan‐Lei , Xu Xin‐Biao , Dong Chun‐Hua , Guo Guang‐Can , Zou Chang‐Ling 
Published: October 2023

AbstractIn a traveling wave microresonator, the cascaded four‐wave mixing (FWM) between optical modes allows the generation of frequency combs, including intriguing dissipative Kerr solitons (DKS). This study explores the quantum fluctuations of frequency combs and reveal the continuous‐variable quantum entanglement between different comb lines of the DKS states. The entanglement of DKS exhibits two distinct characteristics. For modes located at the spectral edge with a small number of excitations, different comb modes with multiple colors become entangled due to photon‐pair generation and coherent photon conversion stimulated by the FWM. Notably, a sudden disappearance of quantum entanglement in the center of the DKS spectrum is observed, which is attributed to the self‐locking phenomena in the FWM network. These findings demonstrate the prominent quantum nature of DKS, which is of fundamental significance in quantum optics and has the potential to be utilized in quantum networking and distributed quantum sensing applications.
Bridging Performance Gaps: Exploring New Classes of Materials for Future Spintronics Technological Challenges
Authors: Al‐Qatatsheh Ahmed , Juodkazis Saulius , Hameed Nishar 
Published: October 2023

AbstractTechnological challenges, such as insufficient computation power, inefficient data storage, and unsafe communication, may not be tackled by currently utilized semiconductors or superconductors, which are still far from meeting the requirements of quantum‐age applications. Spintronics, focused on electron transport phenomena dependent on spin, holds promise as an advanced technology. Nevertheless, most recent quantum technologies adopted by leading businesses and start‐ups rely heavily on others, and there is a race to increase the number of qubits to gain a computational advantage. Therefore, it is crucial to consider new classes of materials instead of the conventional ones. Developing high‐performance organic spintronics based on new classes of materials, namely, ionic liquids (ILs), liquid and soft crystals, and macroradicals, can support high‐speed and low‐power computing applications, offering higher spin‐relaxation times in the order of microsecond at room temperature. This perspective discusses the key challenges of the currently utilized inorganic semiconductors, small molecules, and π‐conjugated polymers. It also discusses how the new classes of organic spintronics can bridge these performance gaps.
Long‐term integration of bahiagrass into a cover‐cropped and strip‐tilled peanut–cotton rotation has a limited effect on soil carbon and other soil properties
Authors: Maltais‐Landry Gabriel , James Michael , Wilson Chris , Schumacher Lesley , Grabau Zane , Sidhu Sudeep , George Sheeja 
Published: October 2023

AbstractIntegrating a perennial forage grass like bahiagrass (Paspalum notatum Flugge) into the traditional rotation of cotton (Gossypium hirsutum L.) and peanut (Arachis hypogaea L.) increases yields and reduces irrigation needs in the Southeast United States. However, the long‐term effects of this sod‐based rotation (SBR) on soil properties remain unclear. Eighteen years after establishing SBR and the traditional rotation, we collected samples to a depth of 120 cm in 30‐cm increments and measured soil carbon and other soil properties (e.g., Mehlich‐extractable nutrients). Soil C was 6% higher with SBR in the top 30 cm of soil after 18 years, with no impact on soil C in deeper soil layers. Similarly, there was no effect of SBR on other soil properties (soil texture, pH, and Mehlich‐extractable P and Mg), except for lower soil K in SBR. Our results indicate a limited effect of SBR on soil C and other properties in this system where SBR is not grazed and where strip tillage and cover cropping were implemented in both rotations.
Preparation of an Activated Carbon Composite with High Thermal Conductivity Based on Emulsified Asphalt and Carbon Nanotubes and its Adsorption Performance for n‐Hexane
Authors: Fu Lipei , Zhang Houye , Si Wenzhe , Zhu Jiahui , Huang Weiqiu , Shao Minglu , Liao Kaili , Xu Peng , Li Bing , Zuo Jiang 
Published: October 2023

AbstractActivated carbon, as the main adsorption material for treating VOCs, has been widely used. To solve the problem of safety hazards in activated carbon adsorption process due to the large amount of heat released, highly thermally conductive composite activated carbon (A‐AC/CNTs) was prepared using asphalt and highly thermally conductive carbon nanotubes (CNTs) for thermal conductivity improvement. Uniform dispersion and firm loading of CNTs in the carbon production material were achieved by dispersing carbon nanotubes (CNTs) in the asphalt‐in‐water emulsion. Experimental results showed that the specific surface area of A‐AC/CNTs reached a maximum when the loading of CNTs was 0.5 wt %. Meanwhile, the thermal conductivity increased by 1.5 times compared with the original activated carbon. The adsorption capacity of n‐hexane reached the maximum of 2868 mmol ⋅ g−1, and the adsorption capacity increased by 21.41 %. It also maintained good regeneration performance after dynamic adsorption experiments.
Development of a consolidated heterogeneous catalytic process for the selective oxidation of carbohydrate‐derived 5‐(hydroxymethyl)furfural for the industrial upscaling of 2,5‐diformylfuran
Authors: Derflinger Christoph , Kamm Birgit , Meissner Gisa , Spod Hendrik , Paulik Christian 
Published: October 2023

AbstractSelective oxidation of 5‐(hydroxymethyl)furfural (HMF) to 2,5‐diformylfuran (DFF) is an important approach for biobased compound valorization through biorefinery. As there is no large‐scale process for this application yet, it is of high importance to find a suitable catalyst system for the production of DFF. In this work, we show that an important step in this direction was taken with a 5 % Ru/Al2O3 catalyst, whereby essentially quantitative selectivities could be obtained in the solvent toluene without the significant formation of over‐oxidation products. A design of experiments approach was used to determine important information about the main process parameters – catalyst amount, oxygen pressure and reaction temperature. By developing an optimised washing method, excellent results were achieved in terms of catalyst reusability, with HMF conversions of over 99.5 % without loss of the catalyst‘s high selectivity after five cycles. Upscaling experiments were performed with the catalyst in a 5‐L reactor at different reactor fill rates, where complete conversion of HMF to DFF was achieved, with a 25 % longer reaction time to achieve full conversion compared to a smaller scale reactor setup.
Ultrasound‐assisted efficient aerobic oxidative coupling of thiols to disulfides with DiMIM‐CH3SO4 as a recyclable ionic liquid catalyst in water: A green approach
Authors: Khataminejad Mohsen , Nowrouzi Najmeh , Saberi Dariush , Aberi Mahdi 
Published: October 2023

AbstractAn ultrasound‐assisted method with specific characteristics of green chemistry for aerobic oxidative coupling of thiols to disulfides is presented. In this method, a readily available ionic liquid catalyzed the aerobic oxidative coupling of thiols to disulfides in water as a green solvent under ultrasonic irradiation at room temperature. In this novel sonocatalysis/ionic liquid protocol, aromatic thiols having both electron‐donating and electron‐withdrawing substituents, alkyl thiols and cysteine, were cleanly converted to the corresponding disulfides in excellent yields. This methodology uses 1,3‐dimethyl imidazolium methyl sulfate (DiMIM‐CH3SO4) ionic liquid as a recyclable catalyst and aerobic oxygen as an oxidative agent. This protocol has the advantages of high yields, short reaction times, lower cost, environmentally friendly reaction media, easy isolation of products, convenient procedure and recoverability of catalyst.
Understanding Critical Aspects of Liposomal Synthesis for Designing the Next Generation Targeted Drug Delivery Vehicle
Authors: Moudgil Aliesha , Chaudhari Bhushan P. 
Published: October 2023

AbstractWe identified process parameters of the thin film hydration technique and intrinsic factors to synthesize liposomes for drug delivery. The thin film formation step impacted the nature of the lipid layer, and we optimized 240 RPM rotation speed, 700 mm of Hg vacuum pressure, and 2 ml of chloroform as the organic solvent. The hydration step controlled the particle specifications, and we optimized 270 RPM rotation speed, PBS as the hydrating medium, and 1 h hydration time. We obtained a comparatively smaller liposomal population with a lower size distribution just after hydrating the lipid layer that required milder downsizing steps −10 extrusion passes through a single polycarbonate membrane. The intrinsic factors including the concentrations and molar ratio of lipids affected the synthesis steps and the particle specifications. Characterization of liposomes by analytical techniques confirmed the synthesis of a monodisperse population with hydrodynamic diameter<150 nm, moderate stability, spherical morphology, and high thermal and storage stability. This comprehensive study defines the role of every parameter, provides a mechanistic insight into synthesis that is supported by experimental data, and helps tune specific parameters to synthesize liposomes for drug delivery or any application with desired specifications.
Prussian Blue and Its Analogues: From Properties to Biological Applications
Authors: Zeng Weihuan , Su Jiajia , Wang Yue , Shou Minyu , Qian Jun , Kai Guoyin 
Published: October 2023

AbstractThe utilization of metal organic framework (MOF) nanocomposites in various biomedical applications has been widely studied because of their unique properties. In recently years, Prussian blue (PB) is widely used in clinical studied due to its biosafety, which has already been approved by USA Food and Drug Administration (FDA). Therefore, it is great urgent to systematically summarize the resent progress to better serve the broad community of researchers. This review focuses on the properties of PB and PB analogues (PBA), and their applications in biological field. A systemic introduction of the properties is presented, including abilities of photothermal, scavenging of reactive oxygen species and adsorption. A variety of biomedical applications, such as tumor therapy, anti‐bacterial infection, biosensor, bioimaging, excretion, ischemic stroke treatment, etc. have been discussed as well. Furthermore, the challenges, key factors, and the prospects in the clinical transformation of PB or PBA are simultaneously discussed. This review will provide reference and guidance for the design and application of PB and PBA in the future.
Stripe‐Like hBN Monolayer Template for Self‐Assembly and Alignment of Pentacene Molecules
Authors: Chesnyak Valeria , Cuxart Marc G. , Baranowski Daniel , Seufert Knud , Cojocariu Iulia , Jugovac Matteo , Feyer Vitaliy , Auwärter Willi 
Published: October 2023

AbstractMetallic surfaces with unidirectional anisotropy are often used to guide the self‐assembly of organic molecules along a particular direction. Such supports thus offer an avenue for the fabrication of hybrid organic–metal interfaces with tailored morphology and precise elemental composition. Nonetheless, such control often comes at the expense of detrimental interfacial interactions that might quench the pristine properties of molecules. Here, hexagonal boron nitride grown on Ir(100) is introduced as a robust platform with several coexisting 1D stripe‐like moiré superstructures that effectively guide unidirectional self‐assemblies of pentacene molecules, concomitantly preserving their pristine electronic properties. In particular, highly‐aligned longitudinal arrays of equally‐oriented molecules are formed along two perpendicular directions, as demonstrated by comprehensive scanning tunneling microscopy and photoemission characterization performed at the local and non‐local scale, respectively. The functionality of the template is demonstrated by photoemission tomography, a surface‐averaging technique requiring a high degree of orientational order of the probed molecules. The successful identification of pentacene's pristine frontier orbitals underlines that the template induces excellent long‐range molecular ordering via weak interactions, preventing charge transfer.
Acidified Nitrogen Self‐Doped Porous Carbon with Superprotonic Conduction for Applications in Solid‐State Proton Battery
Authors: Zhao Feng‐Jia , Zhu Yun , Chen Ying , Ren Xing‐Yu , Dong Hao , Zhang Han , Ren Qiu , Luo Hong‐Bin , Zou Yang , Ren Xiao‐Ming 
Published: October 2023

AbstractSolid proton electrolytes play a crucial role in various electrochemical energy storage and conversion devices. However, the development of fast proton conducting solid proton electrolytes at ambient conditions remains a significant challenge. In this study, a novel acidified nitrogen self‐doped porous carbon material is presented that demonstrates exceptional superprotonic conduction for applications in solid‐state proton battery. The material, designated as MSA@ZIF‐8‐C, is synthesized through the acidification of nitrogen‐doped porous carbon, specifically by integrating methanesulfonic acid (MSA) into zeolitic imidazolate framework‐derived nitrogen self‐doped porous carbons (ZIF‐8‐C). This study reveals that MSA@ZIF‐8‐C achieves a record‐high proton conductivity beyond 10−2 S cm−1 at ambient condition, along with good long‐term stability, positioning it as a cutting‐edge alternative solid proton electrolyte to the default aqueous H2SO4 electrolyte in proton batteries.