bluuebunny/crossref_metadata_2025_split huggingface dataset:
Long‐term clinical and radiological outcomes of endoscopic ultrasound‐guided radiofrequency ablation of benign insulinomas
Authors: Debraine Zoé , Borbath Ivan , Deprez Pierre , Bosly Florence , Maiter Dominique , Furnica Raluca M. 
Published: October 2023

AbstractObjectiveIn recent years, endoscopic ultrasound‐guided radiofrequency ablation (EUS‐RFA) has emerged as an alternative nonsurgical treatment for pancreatic neuroendocrine tumours. The aim of our study was to assess the long‐term follow‐up of patients treated with EUS‐RFA for a sporadic insulinoma in our centre in terms of efficacy, safety and risk of recurrence.Design, Patients and MeasurementsWe retrospectively analysed the data of 11 patients with an insulinoma treated by EUS‐RFA in our tertiary centre between June 2018 and April 2022. Clinical and biological, as well as imaging, follow‐up was planned at 3, 6, 12 months and then annually.ResultsIn our series, there were nine women and two men with a median age of 65 years. All tumours were sporadic, with a mean size of 11 mm. The procedure allowed an immediate and complete symptomatic and biological remission in all patients without notable complications. Complete radiological resolution of the tumour after ablation was observed in seven patients, and persistence of an asymptomatic tumour residue was observed in four patients. During the mean follow‐up period of 26 months, two patients presented a significant but asymptomatic increase of the tumour residue; a second EUS‐RFA session was performed in one patient and the other patient is being closely monitored.ConclusionsEUS‐RFA treatment of benign insulinomas provides a long‐term complete clinical resolution of hypoglycaemia. A long‐term follow‐up is essential if residual tumour persists after initial EUS‐RFA treatment.
Perspectives of carriers of X‐linked retinal diseases on genetic testing and gene therapy: A global survey
Authors: Gocuk Sena A. , Edwards Thomas L. , Jolly Jasleen K. , Ayton Lauren N. 
Published: October 2023

AbstractFemale carriers of X‐linked inherited retinal diseases (IRDs) are burdened with potentially passing their disease‐causing variant to future generations, as well as exhibiting signs of retinal disease themselves. This study aimed to investigate carriers' experiences of genetic testing, emotions relating to having affected children, and their knowledge regarding genetic testing and gene therapy. An online survey was advertised to self‐identified carriers worldwide. Two hundred and twenty‐eight carriers completed the survey with mean age of 51 years (SD ± 15.0). A majority of respondents resided in the United States of America (51%), Australia (19%), and the United Kingdom (14%). Most carriers identified with feelings of guilt (70%), concern (91%), and anxiety (88%) for their child. Female carriers who had given birth to children had significantly greater gene therapy knowledge compared to carriers who had not (p < 0.05). Respondents agreed that their eyecare provider and general practitioner helped them understand their condition (63%), however, few carriers reported receiving psychological counselling (9%) or family planning advice (5%). Most respondents (78%) agreed that gene therapy should be available to carriers. This study emphasises the importance of providing appropriate counselling to female carriers and illustrates the motivation of many to participate in emerging treatment options, such as gene therapy.
A review on sinoscopy in the horse: Traditional and minimally invasive techniques and sinoscopic treatment of paranasal disease
Authors: Bonilla Alvaro G. 
Published: October 2023

SummarySinoscopy consists of direct visualisation of the paranasal sinuses and was first conceived for diagnostic purposes using a rigid endoscope through a skull trephination. Since then, the use and approaches to perform it have evolved thanks to current advancements in knowledge (sinus anatomy and pathology) and technology. The aim of this article is to review the techniques reported to perform traditional and minimally invasive sinoscopy and to review the current use of sinoscopy to treat paranasal sinus disease. The history of sinoscopy, as we know it today, is relatively recent, but its use among clinicians is not necessarily widespread despite the invasiveness of the traditional technique when compared to imaging techniques. This limitation could be bypassed using the newer intranasal or extranasal minimally invasive sinoscopic approaches. These techniques allowed sinoscopic visualisation through natural orifices or minimally invasively created openings. Despite the potential of these techniques, case selection is still crucial as visualisation can be limited in selected disorders (i.e. sinus cyst), some sinuses (i.e. rostral maxillary with intranasal approaches) and if haemorrhage or severe exudate accumulation is found. Nevertheless, sinoscopy offers a diagnostic rate superior to traditional imaging and it is an alternative diagnostic tool when advanced imaging techniques, such as CT, are not available. In recent years, sinoscopic treatment has been progressively replacing the use of sinusotomies to treat most sinus disorders. Sinoscopic treatment yields a high‐resolution rate while complications are kept low. Familiarisation with sinoscopic techniques and in‐depth anatomic sinus knowledge will likely make sinoscopy the gold standard technique to treat sinus disease in the near future.
Tree species diversity increases soil microbial carbon use efficiency in a subtropical forest
Authors: Duan Pengpeng , Fu Ruitong , Nottingham Andrew T. , Domeignoz‐Horta Luiz A. , Yang Xinyi , Du Hu , Wang Kelin , Li Dejun 
Published: October 2023

AbstractPlant communities strongly influence soil microbial communities and, in turn, soil carbon (C) cycling. Microbial carbon use efficiency (CUE) is an important parameter for predicting soil C accumulation, yet how plant and soil microbial community traits influence microbial CUE remains poorly understood. Here, we determined how soil microbial CUE is influenced by plant and soil microbial community traits, by studying a natural gradient of plant species diversity in a subtropical forest. Our results showed that microbial CUE increased with increasing tree species diversity, suggesting a correlation between plant community traits and soil C storage. The specific soil properties that explained the greatest variation in microbial CUE were associated with microbial communities (biomass, enzyme activities and the ratio of oligotrophic to copiotrophic taxa); there were weaker correlations with plant‐input properties, soil chemistry and soil organic C quality and its mineral protection. Overall, high microbial CUE was associated with soil properties correlated with increased tree species diversity: higher substrate availability (simple SOM chemical structures and weak mineral organic associations) and high microbial growth rates despite increased community dominance by oligotrophic strategists. Our results point to a mechanism by which increased tree species diversity may increase the forest C sink by affecting carbon use with the soil microbial community.
Serum RNase L levels in patients with chronic hepatitis B virus infection
Authors: Chen Chi‐Ling , Tseng Tai‐Chung , Liu Chun‐Jen , Kao Jia‐Horng , Chen Pei‐Jer , Yang Wei‐Shiung 
Published: October 2023

AbstractBackground/AimsChronic hepatitis B virus (HBV) infection still poses a major threat to global health. Oligoadenylate synthetase–ribonuclease L (RNase L) antiviral pathway is one of interferon‐induced antiviral effectors. The relationship between RNase L and HBV has never been investigated and we aim to examine the serum RNase L levels in patients with different stages of chronic HBV infection.MethodsThe patients were enrolled from 1985 to 2000, who had been HBsAg positive for longer than 6 months, at the National Taiwan University Hospital. In total, 426 patients with chronic HBV infection were included in this study, including 135 inactive carriers, 148 cirrhosis, and 143 hepatocellular carcinoma (HCC) cases.ResultsThe RNase L levels increase as the disease severity increases. Higher RNase L levels were associated with higher HBV viral load, and the HBV‐RNase L relationship was replaced by the disease severity status when adding disease status into the model. Compared with inactive carriers, the risk of liver cirrhosis was 60‐fold (odds ratio = 60.8, 95% confidence interval = 3.49–1061) with the highest quintile of RNase L levels, after the adjustment of HBV DNA. The dose–response trend was statistically significant with quintiles and one increment of RNase L level in relation to liver cirrhosis. Similar results were found when HCC was compared with inactive carriers, while there was no association when compared between liver cirrhosis and HCC.ConclusionsA positive relationship between serum RNase L and HBV viral titers or advanced disease status is uncovered in this study. Further investigation in this area may provide more details of an innate immune response for HBV and opportunity for novel therapeutic strategy.
Charting the evolution of research on the paradoxes in consumer choice—Systematic review and future research agenda
Authors: Sharma Arun , Sharma Manisha 
Published: October 2023

AbstractThe paradoxical findings in consumer choice research have captivated the interest of many scholars from diverse fields and transformed the understanding of consumer decision‐making. This paper is the first attempt to systematically review, synthesize, and integrate the paradoxical findings in consumer choice research. One of the first paradoxical findings was the violations of value maximation models of rational choice. The second important paradox in consumer choice research is the puzzling role of variety in consumer choices. We focus on these two critical paradoxes discovered in consumer choice literature over the last five decades and refer to them as the “paradox of rational choice” and the “paradox of variety.” We conducted a co‐citation cluster analysis to help identify the most significant studies in the domain. The cluster analysis helped eliminate the subjective bias in article selection. We also used inferential analysis to widen the scope of clusters to other relevant and especially recent studies. A review of 233 papers published between 1972 and 2023 reveals the four themes covering the two paradoxes of consumer choice. The first theme covers the first paradox: the paradox of rational choice. It presents research on preference reversals and other violations of value maximization rational choice models due to contextual factors and choice environment. The following three themes cover the second paradox of consumer choice: the paradox of variety. The second theme focuses on the benefits of variety and the natural desire of consumers to seek more variety. Paradoxically, the third theme highlights when and why variety will likely cause harmful psychological consequences for consumers. Finally, the last theme reconciles the opposing ideas of themes two and three by identifying the boundary conditions and suggesting ways to resolve this paradox. We also provide research directions that scholars can consider for future research related to each of these themes.
Influence of Poaceae flours on the empirical rheology, processing, quality characteristics of pizza base and digestibility studies
Authors: Padmaiah Madhushree , Kathalsar Ashwath Kumar , Chandrashekhar Soumya , Prabhasankar Pichan 
Published: October 2023

SummaryThe study focused on utilising the flours of the Poaceae family to replace whole wheat flour (WWF) in pizza. The millet blend (MB) was prepared using finger millet and pearl millet flours and mixed in a 1:1 ratio. The WWF was replaced with MB at 0%, 25%, 50%, 75% and 100% levels and studied its effect on empirical rheology, technical aspects of processing, micro‐structural and nutritional characteristics of pizza base (PB). The incorporation of MB to WWF significantly diminished the water absorption capacity (80–40%) and increased the dough development time (4.27–14.37 min) and stability (2.35–11.07). Starch pasting studies indicated that with the incorporation of MB, the gelatinization temperature increased (63.6–76.3 °C), and all the other viscosity parameters decreased with the incorporation of MB. Texture profile studies showed that the hardness of the PB increased and lost visco‐elastic properties due to the presence of MB. The sensory score indicated that up to 50% incorporation of MB was acceptable, with a 7.5 (MBPB) score. The protein matrix was disrupted, and starch granules leached out due to MB addition. The results of nutritional studies revealed a significant increase in ash (2.01–2.73%), dietary fibre (9.40–11.19), protein (4.96–6.88%) and in‐vitro protein digestibility (41.77–49.80), and decrease in in‐vitro starch digestibility (28.41–17.97%) and estimated glycemic index (59–56) values in MBPB indicating the benefits of utilising millet flours in the new generation foods such as pizza bases for diversification.
Temporal dynamics of aroma compounds and precursors in dry‐fried shredded beef during culinary processing
Authors: Chen Lilan , Yuan Can , Zhang Fuyan , Qiao Mingfeng , Yi Yuwen , Wu Huachang , Zhang Jiamin 
Published: October 2023

SummaryThis study aimed to investigate aroma compound transformation and precursor relation in dry‐shredded beef using gas chromatography–ion mobility spectrometry, gas chromatography–mass spectrometry, high‐performance liquid chromatography, and electronic nose technologies. Forty‐eight aroma compounds were identified, of which twelve (pentanal, hexanal, heptanal, 3‐methylbutanal, nonanal, phenylacetaldehyde, trans‐2‐decenal, acetoin, 3‐octenol, 3‐octanol, ethyl hexanoate, and 2‐acetylthiazol) exhibited odour activity values (OAVs) >1. The concentration of fatty acids (FAs) decreased progressively, while that of 19 free amino acids (FAAs) increased with prolonged cooking. Pearson's correlation analysis revealed correlations between aroma components (OAV >1), FAAs, and FAs. Specifically, 2‐acetylthiazol, acetoin, heptanal, 3‐methylbutanal, and hexanal exhibited positive correlations, while phenylacetaldehyde and trans‐2‐decenal showed inverse correlations with most FAAs. Notably, phenylacetaldehyde positively correlated with C16:0, C18:1, n9c, and C18:2, n6c. This research presents a practical framework for the application of analytical and computational techniques in the commercial production of cooked beef and meat products.
Serum albumin levels as a useful complementary marker for erectile dysfunction in ulcerative colitis: A cross‐sectional study
Authors: Yamamoto Yasunori , Furukawa Shinya , Miyake Teruki , Yoshida Osamu , Shiraishi Kana , Hashimoto Yu , Tange Kazuhiro , Kitahata Shogo , Ninomiya Tomoyuki , Yagi Sen , Hanayama Masakazu , Suzuki Seiyuu , Shibata Naozumi , Murakami Hidehiro , Ohashi Katsuhisa , Tomida Hideomi , Takeshita Eiji , Ikeda Yoshio , Hiasa Yoichi 
Published: October 2023

ObjectiveRecently, a close association between ulcerative colitis (UC) and erectile dysfunction (ED) was reported. An inverse relationship between serum albumin and ED is found in patients with chronic disease. However, the association between serum albumin levels and ED in patients with UC is unclear. This study aims to investigate this issue in Japanese patients with UC.MethodsOne hundred and thirty‐six Japanese male UC patients were enrolled in this study. Information on serum albumin levels and medications for UC from medical records, Sexual Health Inventory for Men (SHIM) score information from self‐administered questionnaires and information on the severity of UC from physician reports were obtained from medical records, self‐administered questionnaires, and reports from physicians. The participants were divided into tertiles based on the total protein, serum globulin, serum albumin, aspartate aminotransferase, and C‐reactive protein levels. The definition of ED and severe ED was SHIM score < 22 and SHIM score < 8, respectively. The association between these serum markers and ED was assessed by multivariate logistic regression.ResultsThe prevalence of severe ED in the low, moderate, and high albumin groups was 66.0%, 51.0%, and 28.3%, respectively. After adjusting for confounding factors, the low albumin group was independently and positively associated with severe ED (adjusted odds ratio: 2.74, 95% confidence interval: 1.03–7.48, p for trend =0.044). No association between other marker and ED was found.ConclusionSerum albumin was independently inversely associated with severe ED in Japanese patients with UC. Hypoalbuminemia might be a useful complementary marker for assessing the prevalence and severity of ED in UC patients.
Coworker networks and the labor market outcomes of displaced workers: Evidence from Portugal
Authors: Garcia‐Louzao Jose , Silva Marta 
Published: October 2023

AbstractThe use of social contacts in the labor market is widespread. This paper investigates the association between personal connections and hiring probabilities as well as re‐employment outcomes of displaced workers in Portugal. The hiring analysis indicates that displaced workers with a direct link to a firm through a former coworker are three times more likely to be hired compared to workers displaced from the same closing event who lack such a tie. Moreover, we show that successful displaced workers with a connection in the hiring firm have higher entry‐level wages and enjoy greater job security.
Chronic venous insufficiency and venous leg ulcers: Aetiology, on the pathophysiology‐based treatment
Authors: Krizanova Olga , Penesova Adela , Hokynkova Alica , Pokorna Andrea , Samadian Amir , Babula Petr 
Published: October 2023

AbstractThe chronic venous disease covers a wide spectrum of venous disorders that are characterized by severely impaired blood return that primarily affects veins in the lower extremities. Morphological and functional abnormalities of the venous system led to chronic venous insufficiency (CVI), and present as leg heaviness/achiness, edema, telangiectasia, and varices. The term ‘chronic venous insufficiency’ (CVI) refers to a disease of greater severity. Venous dysfunction is associated with venous hypertension and is associated with venous reflux due to poorly functioning or incompetent venous valves, which ultimately reduces venous return, leading to a cascade of morphological, physiological, and histologic abnormalities such as blood pooling, hypoxia, inflammation, swelling, skin changes (lipodermatosclerosis), and in severe cases, venous leg ulcers (VLU). This review summarizes recent knowledge about the aetiology, risk factors, and pathophysiology of VLU and compared the possibilities of their treatment.
Incidence and risk factors of surgical site infection following cervical laminoplasty: A retrospective clinical study
Authors: Wang Jinzuo , Chang Yvang , Suo Moran , Huang Huagui , Liu Xin , Li Zhonghai 
Published: October 2023

AbstractThere are many debates regarding the risk factors of surgical site infection (SSI) following posterior cervical surgery in previous studies. And, till now there is no such a study to examine cervical laminoplasty surgery. From January 2011 through October 2021, a total of 405 patients who were treated with unilateral open‐door laminoplasty surgeries were enrolled in this study. We divided the patients into the SSI group and the non‐SSI group and compared their patient‐specific and procedure‐specific factors. Univariate and multiple logistic regression analysis were performed to determine the risk factors. Of the 405 patients, 20 patients had SSI. The rate of SSI found to be 4.93%. There were significant differences between groups in the thicker subcutaneous fat thickness (FT) (p < 0.001), the higher ratio of subcutaneous FT to muscle thickness (MT) (p < 0.001), the higher preoperative Japanese Orthopaedic Association (JOA) Scores (p < 0.003), the decreased preoperative serum albumin (p < 0.001), the more postoperative drainage (p < 0.05) and the longer time of draining (p < 0.001). Logistic regression analysis of these differences showed that the higher ratio of subcutaneous FT/MT, the higher preoperative JOA scores, the decreased preoperative serum albumin and the longer time of draining were significantly related to SSI (p < 0.05). The higher ratio of subcutaneous FT/MT, the higher preoperative JOA scores, the decreased preoperative serum albumin and the longer time of draining are identified as the independent risk factors of SSI in cervical laminoplasty. Identification of these risk factors could be useful in reducing the SSI incidence and patients counselling.
Anomalous critical behavior and localized ferromagnetism of the half‐metallic double perovskite Sr2CrReO6
Authors: Liu Hao , Wang Shuhao , Yu Benwei , Ma Chunlan , Llamazares J. L. Sánchez , Wang Caixia , Zhu Yan , Yang Hao , Fan Jiyu 
Published: October 2023

AbstractDouble perovskites such as Sr2CrReO6 attract great scientific attention owing to their high Curie temperatures (TC ≥ 550 K) as well as large magnetoresistances. However, both the specific physical mechanism of high TC and magnetic ground state in Sr2CrReO6 remain ill‐defined. In order to clarify and understand these issues, we studied its critical phase transition characteristics using critical behavior analysis. We found that the obtained critical exponents (β = 1.115 and γ = 2.224) are quite different from any traditional universality class. The abnormal critical behavior implies that at the quantum critical point, Sr2CrReO6 exists a strong competition among several magnetic interactions. By analyzing their effective critical exponents, we show that the double perovskite Sr2CrReO6 is really an ordered and homogeneous ferromagnet. With the help of Takahashi's theory, the nature of ferromagnetism in Sr2CrReO6 is confirmed to be localized instead of itinerant. The results of this research will provide new insights into the origins of high TC as well as the magnetic ground state in this double perovskite.
A novel binding pocket in the D2 domain of protein tyrosine phosphatase mu (PTPmu) guides AI screen to identify small molecules that modulate tumour cell adhesion, growth and migration
Authors: Molyneaux Kathleen , Laggner Christian , Brady‐Kalnay Susann M. 
Published: October 2023

AbstractApproximately 40% of people will get cancer in their lifetime in the US, and 20% are predicted to die from the condition when it is invasive and metastatic. Targeted screening for drugs that interact with proteins that drive cancer cell growth and migration can lead to new therapies. We screened molecular libraries with the AtomNet® AI‐based drug design tool to identify compounds predicted to interact with the cytoplasmic domain of protein tyrosine phosphatase mu. Protein tyrosine phosphatase mu (PTPmu) is proteolytically downregulated in cancers such as glioblastoma generating fragments that stimulate cell survival and migration. Aberrant nuclear localization of PTPmu intracellular fragments drives cancer progression, so we targeted a predicted drug‐binding site between the two cytoplasmic phosphatase domains we termed a D2 binding pocket. The function of the D2 domain is controversial with various proposed regulatory functions, making the D2 domain an attractive target for the development of allosteric drugs. Seventy‐five of the best‐scoring and chemically diverse computational hits predicted to interact with the D2 binding pocket were screened for effects on tumour cell motility and growth in 3D culture as well as in a direct assay for PTPmu‐dependent adhesion. We identified two high‐priority hits that inhibited the migration and glioma cell sphere formation of multiple glioma tumour cell lines as well as aggregation. We also identified one activator of PTPmu‐dependent aggregation, which was able to stimulate cell migration. We propose that the PTPmu D2 binding pocket represents a novel regulatory site and that inhibitors targeting this region may have therapeutic potential for treating cancer.