bluuebunny/crossref_metadata_2025_split huggingface dataset:
The Stoic Theory of Implanted Preconceptions
Authors: Jackson-McCabe Matt 
Published: February 2005

AbstractA number of late Stoic sources describe either ethical concepts or a supposed universal belief in gods as being innate in the human animal. Though Chrysippus himself is known to have spoken of "implanted preconceptions" (ε¨μϕυτοιπρολν´ψειζ) of good and bad, scholars have typically argued that the notion of innate concepts of any kind would have been entirely incompatible with his theory of knowledge. Both Epictetus' notion of innate concepts of good and bad and the references to an innate belief in gods by other philosophers of the Roman era are thus generally held to be later developments, probably owing to a Platonist-Stoic syncretism. Review of the evidence, however, shows that Chrysippus, like Epictetus, held ethical concepts to represent a special category of conception in that their formation was guaranteed by oikeiôsis. Unlike other concepts, that is, these represent a formal conceptualization of an innate tendency to distinguish between things fitting for one's constitution and things not fitting that all animals, according to the Stoics, bring to their empirical experiences. While the notion that human belief in gods is similarly innate does seem to have been a later development, it too was explained with reference to oikeiôsis rather than resulting from a simple "syncretism."
The Unity of Intellect in Aristotle's De Anima
Authors: Gerson Lloyd 
Published: February 2005

AbstractThe perennial problem in interpreting De Anima 3.5 has produced two drastic solutions, one ancient and one contemporary. According to the first, Aristotle in 3.5 identi fies the 'agent intellect' with the divine intellect. Thus, everything Aristotle has to say about the human intellect is contained mainly in 3.4, though Aristotle returns to its treatment in 3.6. In contrast to this ancient interpretation, a more recent view holds that the divine intellect is not the subject of 3.5 and that throughout the work Aristotle is analyzing the nature of the human intellect. But this view contends that the properties Aristotle deduces for this intellect, properties that have encouraged the view that Aristotle must be speaking about a divine intellect, are in fact to be discounted or interpreted in such a way that they do not indicate the immortality and immateriality of the human intellect. In this article I argue that close attention to the text and the sequence of argument supports the conclusion that Aristotle is speaking throughout De Anima of a uni fied human intellect, possessed of the properties Aristotle explicitly attributes to it. This intellect functions diff erently when it is and when it is not separate from the hylomorphic composite. I argue further that it is Aristotle's view that if we were not ideally or essentially intellects, we could not engage in the diverse cognitive activities of this composite.
What Kind of Hedonist was Epicurus?
Authors: Woolf Raphael 
Published: February 2005

AbstractThis paper addresses the question of whether or not Epicurus was a psychological hedonist. Did he, that is, hold that all human action, as a matter of fact, has pleasure as its goal? Or was he just an ethical hedonist, asserting merely that pleasure ought to be the goal of human action? I discuss a recent forceful attempt by John Cooper to answer the latter question in the affirmative, and argue that he fails to make his case. There is considerable evidence in favour of a psychological reading of Epicurean hedonism, evidence that includes some of the very texts that Cooper cites in support of the ethical reading.
Embryological Models in Ancient Philosophy
Authors: Henry Devin 
Published: February 2005

AbstractHistorically embryogenesis has been among the most philosophically intriguing phenomena. In this paper I focus on one aspect of biological development that was particularly perplexing to the ancients: self-organisation. For many ancients, the fact that an organism determines the important features of its own development required a special model for understanding how this was possible. This was especially true for Aristotle, Alexander, and Simplicius, who all looked to contemporary technology to supply that model. However, they did not all agree on what kind of device should be used. In this paper I explore the way these ancients made use of technology as a model for the developing embryo. I argue that their di ff erent choices of device reveal fundamental di ff erences in the way each thinker understood the nature of biological development itself. In the fi nal section of the paper I challenge the traditional view (dating back to Alexander's interpretation of Aristotle) that the use of automata in GA can simply be read o ff from their use in the de motu.
A Language of Their Own: An Interactionist Approach to Human-Horse Communication
Authors: Brandt Keri 
Published: February 2005

AbstractThis paper explores the process of human-horse communication using ethnographic data of in-depth interviews and participant observation. Guided by symbolic interactionism, the paper argues that humans and horses co-create a language system by way of the body to facilitate the creation of shared meaning. This research challenges the privileged status of verbal language and suggests that non-verbal communication and language systems of the body have their own unique complexities. This investigation of humanhorse communication offers new possibilities to understand the subjective and intersubjective world of non-verbal language using beings—human and nonhuman alike.
Roadkill: Between Humans, Nonhuman Animals, and Technologies
Authors: Michael Mike 
Published: February 2005

AbstractThis paper has two broad objectives. First, the paper aims to treat roadkill as a topic of serious social scientific inquiry by addressing it as a cultural artifact through which various identities are played out. Thus, the paper shows how the idea of roadkill-as-food mediates contradictions and ironies in American identities concerned with hunting, technology, and relationships to nature. At a second, more abstract, level, the paper deploys the example of roadkill to suggest a par ticular approach to theorizing broader relationships between humans, nonhuman animals, and technology. This paper draws on recent developments in science and technology studies, in particular, the work of Latour (1993) and Serres (1982,1985), to derive a number of prepositional metaphors. The paper puts these forward tentatively as useful tools for exploring and unpicking some of the complex connections and heterogeneous relationalities between humans, animals, and the technology from which roadkill emerges.
In It for the Nonhuman Animals: Animal Welfare, Moral Certainty, and Disagreements
Authors: Taylor Nicola 
Published: February 2005

AbstractBased on three years' ethnographic research with animal sanctuary workers, this paper argues that a level of moral certainty drives and justifies many of the workers' actions and beliefs. Similar to the "missionary zeal" of nonhuman animal rights activists, this moral certainty divides the world into two neat categories: good for the animals and bad for the animals. This overriding certainty takes precedence over other concerns and pervades all aspects of sanctuary life, resulting in the breakdown of different facets of that life into good and bad homes, good and bad animals, and good and bad workers. The paper, therefore, argues that animal welfare workers may be as "radical" as animal rights activists in one respect—their adherence to the overriding principle of being "in it for the animals."
From Transitory Status to Perpetual Sententiae: Rethinking Polygamy in Islamic Traditions
Authors: Souaiaia Ahmed 
Published: February 2005

AbstractPolygamy and inequity in inheritance rights are two fundamental concerns that continue to challenge the logic and practice concerning the way women are treated in Islamic society. These two subjects remain beyond the scope of critical analysis due in part to the explicit legal proof (dalīl) that is found in the Qur'ān. How explicit are such legal proofs in general and is there any scope for an alternative interpretation? The consensus that emerged on these two matters would suggest that there is none. However, in this paper, I would argue that the perceived consensus is guided and dictated by the fact that during the formative period of Islamic law, interpretive and normative disciplines were dominated by men; hence, the male bias. It can be argued, based on historical and linguistic evidence, that there is a very plausible alternative understanding that is radically different from any of those proposed by traditionalists.
The Nature and Elements of Sacrificial Ritual
Authors: McClymond Kathryn 
Published: February 2005

AbstractAfter delineating several basic sacrificial activities in the context of the Vedic and Israelite traditions, the following essay makes three observations about the nature of sacrifice. First, despite the emphasis on death and violence in many dominant treatments, close study indicates that sacrifice is largely a non-violent activity. Therefore, it is inappropriate to focus on killing as a definitive or central element of sacrificial ritual. Second, sacrificial systems include animal, vegetal, and liquid oblations, yet vegetal and liquid substances are generally overlooked in sacrificial theorizing. Consequently, sacrificial theories that are driven by animal sacrifice need to be adjusted to address the full spectrum of sacrificial oblations and activity. Finally, sacrificial ritual is best understood as the dynamic interplay of various sacrificial elements rather than a monolithic event marked by a single, definitive activity. This paper offers an alternative polythetic approach that focuses on clusters of sacrificial activity.
Deregulation of proteins involved in iron metabolism in hepcidin-deficient mice
Authors: Viatte Lydie , Lesbordes-Brion Jeanne-Claire , Lou Dan-Qing , Bennoun Myriam , Nicolas Gaël , Kahn Axel , Canonne-Hergaux François , Vaulont Sophie 
Published: February 2005

Abstract
Evidence is accumulating that hepcidin, a liver regulatory peptide, could be the common pathogenetic denominator of all forms of iron overload syndromes including HFE-related hemochromatosis, the most prevalent genetic disorder characterized by inappropriate iron absorption. To understand the mechanisms whereby hepcidin controls iron homeostasis in vivo, we have analyzed the level of iron-related proteins by Western blot and immunohistochemistry in hepcidin-deficient mice, a mouse model of severe hemochromatosis. These mice showed important increased levels of duodenal cytochrome b (Dcytb), divalent metal transporter 1 (DMT1), and ferroportin compared with control mice. Interestingly, the level of ferroportin was coordinately up-regulated in the duodenum, the spleen, and the liver (predominantly in the Kupffer cells). Finally, we also evidenced a decrease of ceruloplasmin in the liver of hepcidin-deficient mice. We hypothesized that the deregulation of these proteins might be central in the pathogenesis of iron overload, providing key therapeutic targets for iron disorders. (Blood. 2005;105:4861-4864)
Sea urchin vault structure, composition, and differential localization during development
Authors: Stewart Phoebe L , Makabi Miriam , Lang Jennifer , Dickey-Sims Carrie , Robertson Anthony J , Coffman James A , Suprenant Kathy A 
Published: February 2005

Abstract
Background
Vaults are intriguing ribonucleoprotein assemblies with an unknown function that are conserved among higher eukaryotes. The Pacific coast sea urchin, Strongylocentrotus purpuratus, is an invertebrate model organism that is evolutionarily closer to humans than Drosophila and C. elegans, neither of which possesses vaults. Here we compare the structures of sea urchin and mammalian vaults and analyze the subcellular distribution of vaults during sea urchin embryogenesis.

Results
The sequence of the sea urchin major vault protein (MVP) was assembled from expressed sequence tags and genome traces, and the predicted protein was found to have 64% identity and 81% similarity to rat MVP. Sea urchin MVP includes seven ~50 residue repeats in the N-terminal half of the protein and a predicted coiled coil domain in the C-terminus, as does rat MVP. A cryoelectron microscopy (cryoEM) reconstruction of isolated sea urchin vaults reveals the assembly to have a barrel-shaped external structure that is nearly identical to the rat vault structure. Analysis of the molecular composition of the sea urchin vault indicates that it contains components that may be homologs of the mammalian vault RNA component (vRNA) and protein components (VPARP and TEP1). The sea urchin vault appears to have additional protein components in the molecular weight range of 14–55 kDa that might correspond to molecular contents. Confocal experiments indicate a dramatic relocalization of MVP from the cytoplasm to the nucleus during sea urchin embryogenesis.

Conclusions
These results are suggestive of a role for the vault in delivering macromolecules to the nucleus during development.
Evolution of the relaxin-like peptide family
Authors: Wilkinson Tracey N , Speed Terence P , Tregear Geoffrey W , Bathgate Ross AD 
Published: February 2005

Abstract
Background
The relaxin-like peptide family belongs in the insulin superfamily and consists of 7 peptides of high structural but low sequence similarity; relaxin-1, 2 and 3, and the insulin-like (INSL) peptides, INSL3, INSL4, INSL5 and INSL6. The functions of relaxin-3, INSL4, INSL5, INSL6 remain uncharacterised. The evolution of this family has been contentious; high sequence variability is seen between closely related species, while distantly related species show high similarity; an invertebrate relaxin sequence has been reported, while a relaxin gene has not been found in the avian and ruminant lineages.

Results
Sequence similarity searches of genomic and EST data identified homologs of relaxin-like peptides in mammals, and non-mammalian vertebrates such as fish. Phylogenetic analysis was used to resolve the evolution of the family. Searches were unable to identify an invertebrate relaxin-like peptide. The published relaxin cDNA sequence in the tunicate, Ciona intestinalis was not present in the completed C. intestinalis genome. The newly discovered relaxin-3 is likely to be the ancestral relaxin. Multiple relaxin-3-like sequences are present in fugu fish (Takifugu rubripes) and zebrafish (Danio rerio), but these appear to be specific to the fish lineage. Possible relaxin-1 and INSL5 homologs were also identified in fish and frog species, placing their emergence prior to mammalia, earlier than previously believed. Furthermore, estimates of synonymous and nonsynonymous substitution rates (dN/dS) suggest that the emergence of relaxin-1, INSL4 and INSL6 during mammalia was driven by positive Darwinian selection, hence these peptides are likely to have novel and in the case of relaxin-1, which is still under positive selection in humans and the great apes, possibly still evolving functions. In contrast, relaxin-3 is constrained by strong purifying selection, demonstrating it must have a highly conserved function, supporting its hypothesized important neuropeptide role.

Conclusions
We present a phylogeny describing the evolutionary history of the relaxin-like peptide family and show that positive selection has driven the evolution of the most recent members of the family.
Comparative genome analysis of cortactin and HS1: the significance of the F-actin binding repeat domain
Authors: van Rossum Agnes GSH , Schuuring-Scholtes Ellen , van Buuren-van Seggelen Vera , Kluin Philip M , Schuuring Ed 
Published: February 2005

Abstract
Background
In human carcinomas, overexpression of cortactin correlates with poor prognosis. Cortactin is an F-actin-binding protein involved in cytoskeletal rearrangements and cell migration by promoting actin-related protein (Arp)2/3 mediated actin polymerization. It shares a high amino acid sequence and structural similarity to hematopoietic lineage cell-specific protein 1 (HS1) although their functions differ considerable. In this manuscript we describe the genomic organization of these two genes in a variety of species by a combination of cloning and database searches. Based on our analysis, we predict the genesis of the actin-binding repeat domain during evolution.

Results
Cortactin homologues exist in sponges, worms, shrimps, insects, urochordates, fishes, amphibians, birds and mammalians, whereas HS1 exists in vertebrates only, suggesting that both genes have been derived from an ancestor cortactin gene by duplication. In agreement with this, comparative genome analysis revealed very similar exon-intron structures and sequence homologies, especially over the regions that encode the characteristic highly conserved F-actin-binding repeat domain. Cortactin splice variants affecting this F-actin-binding domain were identified not only in mammalians, but also in amphibians, fishes and birds. In mammalians, cortactin is ubiquitously expressed except in hematopoietic cells, whereas HS1 is mainly expressed in hematopoietic cells. In accordance with their distinct tissue specificity, the putative promoter region of cortactin is different from HS1.

Conclusions
Comparative analysis of the genomic organization and amino acid sequences of cortactin and HS1 provides inside into their origin and evolution. Our analysis shows that both genes originated from a gene duplication event and subsequently HS1 lost two repeats, whereas cortactin gained one repeat. Our analysis genetically underscores the significance of the F-actin binding domain in cytoskeletal remodeling, which is of importance for the major role of HS1 in apoptosis and for cortactin in cell migration.
A class of models for analyzing GeneChip® gene expression analysis array data
Authors: Fan Wenhong , Pritchard Joel I , Olson James M , Khalid Najma , Zhao Lue Ping 
Published: February 2005

Abstract
Background
Various analytical methods exist that first quantify gene expression and then analyze differentially expressed genes from Affymetrix GeneChip® gene expression analysis array data. These methods differ in the choice of probe measure (quantification of probe hybridization), summarizing multiple probe intensities into a gene expression value, and analysis of differential gene expression. Research papers that describe these methods focus on performance, and how their approaches differ from others. To better understand the common features and differences between various methods, and to evaluate their impact on the results of gene expression analysis, we describe a class of models, referred to as generalized probe models (GPMs), which encompass various currently available methods.

Results
Using an empirical dataset, we compared different formulations of GPMs, and GPMs with three other commonly used methods, i.e. MAS 5.0, dChip, and RMA. The comparison shows that, on a genome-wide scale, different methods yield similar results if the same probe measures are chosen.

Conclusion
In this paper we present a general framework, i.e. GPMs, which encompasses various methods. GPMs permit the use of a wide range of probe measures and facilitate appropriate comparison between commonly used methods. We demonstrate that the dissimilar results stem primarily from different choice of probe measures, rather than other factors.
Response of SII cortex to ipsilateral, contralateral and bilateral flutter stimulation in the cat
Authors: Tommerdahl Mark , Simons Stephen B , Chiu Joannellyn S , Tannan Vinay , Favorov Oleg , Whitsel Barry 
Published: February 2005

Abstract
Background
A distinctive property of SII is that it is the first cortical stage of the somatosensory projection pathway that integrates information arising from both sides of the body. However, there is very little known about how inputs across the body mid-line are processed within SII.

Results
Optical intrinsic signal imaging was used to evaluate the response of primary somatosensory cortex (SI and SII in the same hemisphere) to 25 Hz sinusoidal vertical skin displacement stimulation ("skin flutter") applied contralaterally, ipsilaterally, and bilaterally to the central pads of the forepaws. A localized increase in absorbance in both SI and SII was evoked by both contralateral and bilateral flutter stimulation. Ipsilateral flutter stimulation evoked a localized increase in absorbance in SII, but not in SI. The SII region that responded with an increase in absorbance to ipsilateral stimulation was posterior to the region in which absorbance increased maximally in response to stimulation of the contralateral central pad. Additionally, in the posterior SII region that responded maximally to ipsilateral stimulation of the central pad, bilateral central pad stimulation approximated a linear summation of the SII responses to independent stimulation of the contralateral and ipsilateral central pads. Conversely, in anterior SII (the region that responded maximally to contralateral stimulation), bilateral stimulation was consistently less than the response evoked from the contralateral central pad.

Conclusions
The results indicate that two regions located at neighboring, but distinctly different A-P levels of the anterior ectosylvian gyrus process input from opposite sides of the body midline in very different ways. The results suggest that the SII cortex, in the cat, can be subdivided into at least two functionally distinct regions and that these functionally distinct regions demonstrate a laterality preference within SII.
Comparative analysis of mouse skeletal muscle fibre type composition and contractile responses to calcium channel blocker
Authors: Mänttäri Satu , Järvilehto Matti 
Published: February 2005

Abstract
Background
In this study, we examined the correlation between excitation-contraction coupling characteristics and skeletal muscle fibre type by (1) localizing the distribution of dihydropyridine receptor (DHPR) protein and (2) comparing the effect of DHPR blocker on muscles with different fibre type composition, in order to better understand the differences between contractile phenotypes of fibres and to explain the contradictory reports to date on the interaction of dihydropyridines with skeletal muscle isoform of DHPR.

Results
Histochemical experiments revealed that fluorophore conjugated dihydropyridines stain selectively the membranes of muscle fibres. The staining was most evident in type IIA fibres. The major fibre type in gluteus and femoris, revealed by mATPase staining, was IIA (45.0 and 38.1 %, respectively). In gastrocnemius the content of IIA fibres was 22.7 %. Contraction forces before and after the addition of blocker for the three muscles investigated were: gluteus 0.075 ± 0.017 N vs. 0.052 ± 0.011 N, femoris 0.045 ± 0.005 N vs. 0.033 ± 0.005 N and gastrocnemius 0.089 ± 0.016 N vs. 0.075 ± 0.014 N, respectively. The attenuation of contraction force proportional to the cross-sectional area of the muscle was significantly (P = 0.023) higher in gluteus (28.3 ± 3.5 %) and femoris (27.6 ± 3.2 %) as compared to gastrocnemius (16.1 ± 2.5 %). However, no significant change in the control measurements was observed ruling out the possibility of fatigue.

Conclusion
The results indicate that the attenuation of the contraction force was largest in muscles with a high percentage of type IIA fibres. This supports our finding that the abundance of dihydropyridine receptors of IIA fibres outnumbers that in the other fibre types. The present data show that the correlation of density of dihydropyridine receptors can be one of the important factors influencing the overall contractile properties of the muscle and for its part explain the contradictory results of previous studies on coupling process.