bluuebunny/crossref_metadata_2025_split huggingface dataset:
The effect of different oral anticoagulants on cognitive function in patients with atrial fibrillation: a Bayesian network meta-analysis
Authors: Ning Wanling , Wang Shiheng , Tang Hanqing , Wu Sichu , Huang XiaoSong , Liu Baiyan , Mao Yilin 
Published: October 2023

Abstract

Objective
Atrial fibrillation (AF) is one of the most common arrhythmias. At present, the treatment for patients with atrial fibrillation mainly includes oral anticoagulants (OACs). Studies have shown that OACs are associated with cognitive decline in patients with atrial fibrillation, but there is a lack of relevant evidence. This study used Bayesian network meta-analysis to investigate the effects of different oral anticoagulants on cognitive decline in patients with atrial fibrillation.
Method
We systematically searched the clinical studies of oral anticoagulants on patients with atrial fibrillation included in PubMed, Web of Science, Embase, and Cochrane library as of July 3, 2023. Use Cochrane's randomized controlled trial bias risk assessment tool and Newcastle Ottawa Scale (NOS) to assess the bias risk of the included studies. The main outcome measure was a decrease in cognitive function.
Result
A total of 10 studies were included, including two RCTs and seven RCSs, including 882847 patients with atrial fibrillation. Including 8 oral anticoagulants: VKAs, Warfarin, Aspirin, Clopidogrel, Dabigatran, Edoxaban, Rivaroxaban, and Apixaban. The results of the mesh meta-analysis showed that VKAs were superior in reducing the risk of cognitive decline in patients with atrial fibrillation compared to warfarin (OR=-1.19, 95% CI (-2.35, -0.06), P < 0.05) (Table 4). The top three in terms of probability of reducing the incidence of cognitive impairment in patients with atrial fibrillation with different oral anticoagulants are VKAs (87%), Rivaroxaban (62.2%), and Dabigatran (60.8%).
Conclusion
Based on the results of this study, VKAs may be the potential best intervention measures that can reduce the risk of cognitive decline in patients with atrial fibrillation. Due to the limitations of this study, more high-quality randomized controlled trials with large samples and multiple centers are needed in the future to provide more evidence.
Evaluation of ecological and health risks of nitrate in groundwater in the northern region
Authors: Ma Xingguan , Jiang Zongyu , Li Xuechun , Mu Penglin 
Published: October 2023

Abstract
The study took the northern area as the object of evaluation by geostatistical software, fuzzy integrated comprehensive evaluation method and potential ecological risk index. The evaluation results were affected by natural geomorphological factors.There were four land types in the area, with varying spatial distribution ratios, as follows,the construction zone type which accounted for 21% of area, the grasslands type which accounted for 32%, the arable land type which accounted for 46%, and the forest land type which accounted for 1%. The ecological risk evaluation index of the study area indicated a slight threat. Using the health risk evaluation model, the children's health risk index were found to be 4.9×10− 3～1.31×10− 2, while the adults' health risk index were 3.2×10− 3～1.13×10− 2. Children were roughly 0.5 times more susceptible to health risks than adults. Therefore, there should be sustained attention to the nitrate groundwater contamination in the study area.
Gynecological bleeding (arteriovenous malformation) (case report)
Authors: Moawen Rawan , khattab Khalid 
Published: October 2023

Abstract

Background: Vascular uterine malformations are rare and are only mentioned in the medical literature (AVMS), which is classified into congenital and acquired. In recent years, an increase in the incidence and recurrence of acquired arteriovenous malformations has been observed following pregnancies, miscarriages, and cesarean sections.
Case Presentation: A patient (35 years old), resident of Damascus, Mezzeh, married for (5) years, has no children, has a normal, sparse sexual life due to her main complaint, which is spontaneous vaginal bleeding, which increases and appears profuse after intercourse. Before marriage, she suffered from menstrual cycles. Heavy, with increased menstrual bleeding during stress, fatigue, and exercise, hemoglobin 8, and after applying the treatment 10, the rest of the laboratory tests were normal, it turned out to be an abnormal case of bleeding. It was diagnosed using color and pulsed Doppler. Modern and advanced radiological methods were used. Doppler, CT, and resonance imaging reported the diagnosis of the case. The patient did not benefit from conservative routine treatment, and it was noted. Patient's response to interventional radiology.
Conclusion: Any bleeding outside the period should not be neglected, and a Doppler should be used and a hand examination should be performed. Radial expert in Doppler techniques. And performing all measurements, including the speed of blood flow at the end of systolic time and the speed of blood flow at the end of diastolic time, measuring the resistance index and pulse, and following up with other radiological methods such as CT and MRI to reach the ideal diagnosis.
Determining the targets of of licorice against postmenopausal osteoporosis: A drug target mendelian randomization study followed network pharmacology analysis
Authors: Shan Shan , Chen Yijie , Zhang Zhifen 
Published: October 2023

Abstract
Background
We aimed to examine the main active components and mechanism of action of licorice against postmenopausal osteoporosis (PMOP) using a network pharmacology approach.And we also use the drug target mendelian Randomization (MR) to estimated the association between protein targets and PMOP, osteoporosis.
Methods
The Traditional Chinese Medicine Systems Pharmacology Database and Analysis Platform was searched for active ingredients and potential targets of licorice. Cytoscape 3.7.2 software was used to build a network between the active components of licorice and its targets. A protein–protein interaction network of the prospective targets of licorice for PMOP treatment was constructed. Enrichment studies using the Gene Ontology and Kyoto Encyclopedia of Genes and Genomes databases were performed on the primary targets. Instrument variables obtained from eQTLGen stroage, the outcome data get from the FinnGEN and Bionbank Japan Project. Primary causal effect was estimated by inverse variance weighted. Leave-one-out analyses and co-localization were uesd to vertifited the driven effect of single nucleotide polymorphism.
Results
We identified 88 potent active compounds from licorice and the corresponding 226 targets of action and retrieved 2,271 osteoporosis-related genes. The main active components were quercetin, kaempferol, naringenin, formononetin, and 7-methoxy-2-methyl isoflavone; the relevant protein targets were RXRA, AKT1, PPARA, TNF, CYP1A1, F2, and STAT3. MR analyses suggested STAT3 has a positive association both with PMOP of European population (odds radio [OR] 1.27, 95% confidence interval [CI] 1.01–1.60) and osteoporosis of East Asian (OR 1.29, 95% CI 1.18–1.41).
Conclusions
The pharmacodynamic effects of licorice for PMOP are the result of multi-component, -target, and -pathway interactions. Licorice may affect the development of PMOP throughSTAT3 gene,tumor, lipid, and arteriosclerosis pathways; chemical carcinogenicity activation; and advanced glycation end products–receptor (AGE–RAGE) pathways, thus providing a scientific basis for using licorice against PMOP.
Newly discovered differences of reproductive traits between island and mainland plants support Baker’s law
Authors: Keller Barbara , Alther Barbara , Jiménez Ares , Koutroumpa Konstantina , Mora-Carrera Emiliano , Conti Elena 
Published: October 2023

Abstract
Background: Reproduction in angiosperms involves either one or two parents, through which selfed/cloned or outcrossed progeny is formed, respectively. Uniparental reproduction is advantageous when lack of mates and/or pollinators limits outcrossing opportunities. Baker’s law predicts that the capacity for uniparental reproduction should be enriched in habitats colonized via long-distance dispersal, such as volcanic islands. To test Baker’s law, we quantified variation of reproductive traits at multiple hierarchical levels and compared seed set after selfing and crossing experiments in both island and mainland populations of Limonium lobatum, a widespread species that Baker described as self-incompatible based on observations of stigma-pollen dimorphism in their flowers. In species with the type of pollen-stigma dimorphism that Baker detected in L. lobatum, pollen of one floral morph typically cannot fertilize ovules of the same floral morph.
Results: We discovered new variation and combinations of pollen-stigma traits never described before and determined that plants with such novel combinations were more common in island than mainland populations. We also documented, for the first time, a lack of correspondence between specific pollen-stigma combinations and pollen compatibility. Furthermore, the results of manual pollination experiments established that selfed seed-set was higher in island than mainland plants, while outcrossed seed-set was lower in island than mainland plants. Overall, more than 80% of all plants were self-compatible, while less than 20% were partially or entirely self-incompatible.
Conclusions: Contrary to previous descriptions by Baker, L. lobatumis a species that includes both self-compatible and self-incompatible plants characterized by both known and previously undescribed combinations of pollen-stigma traits. This type of variation was previously unknown in Plumbaginaceae and the lack of correspondence between pollen-stigma combinations was never described outside the highly variable species complex of Armeria maritima. Furthermore, island populations of L. lobatum harbor more plants with the newly discovered pollen-stigma combinations than mainland populations and are enriched in their capability for uniparental reproduction, corroborating Baker’s law. Our study establishes a link between variability of reproductive traits and capability of uniparental reproduction on islands, connecting research on reproductive and island biology.
Whole genome sequencing of actinobacterial strain Amycolatopsis sp. (BCA-696) identifies the underlying plant growth-promoting genes
Authors: Gandham Prasad , Vadla Nandini , Saji Angeo , Vadlamudi Srinivas , Ruperao Pradeep , Selvanayagam Sivasubramani , K.Saxena Rachit , Rathore Abhishek , Gopalakrishnan Subramaniam , Thakur Vivek 
Published: October 2023

Abstract
The complete genome sequence of one rare actinobacteria Amycolatopsis sp. BCA−696 was characterized in this study. BCA−696 was previously reported as a biocontrol agent against charcoal rot in sorghum and a plant growth-promoting agent in sorghum and chickpea. The next-generation sequencing based whole draft genome of BCA−696 comprises of ~ 9.05Mb circular chromosome with 68.75% GC content. In total, 8,716 protein-coding sequences and 61 RNA-coding sequences were predicted, and the species-specific genomic features of Amycolatopsis sp. BCA−696 was analysed. Here we also report the Amycolatopsis sp. BCA−696 produces the glycopeptide antibiotic vancomycin that inhibits the growth of pathogenic gram-positive bacteria. Moreover, BCA−696 possesses 23 biosynthetic gene clusters (BGCs) that may be of biological importance. The comparative genomic analysis of BCA−696 and fourteen other strains of Amycolatopsis revealed a total of 3,627 core and 1,423 unique orthologous genes present in the genome. The number of unique genes ranged from 654 to 2557 across 15 strains of Amycolatopsis. Genome assembly of the BCA−696 also provided genes involved in key pathways related to plant growth promotion (PGP) and biocontrol traits such as siderophores, chitinase, and cellulase.
Platelet Rich Fibrin for rehydration and pre-vascularization of an acellular, collagen membrane of porcine origin
Authors: Schröger Saskia-Vanessa , Blatt Sebastian , Sagheb Kawe , Al-Nawas Bilal , Kämmerer Peer W. , Sagheb Keyvan 
Published: October 2023

Abstract
Objectives Pre-Vascularization of collagen membranes with autologous platelet concentrates is a standard procedure in oral and maxillofacial surgery. This study analyzed the possible interaction of an acellular collagen membrane of porcine origin (NM) with platelet-rich fibrin (PRF) regarding its rehydration protocol with differences in pH values and effect on angiogenesis.
Materials and methods NM was analyzed alone and combined with solid PRF by plotting or co-culturing with injectable PRF. Different media (venous blood, buffer solution with a fixed pH value of 7, saline solution, and injectable PRF) were used to analyze the influence on pH value during rehydration. Chorion allantois membrane assay (CAM) was applied to check pro-angiogenic effects after 24, 48, and 72 hours, followed by immunohistochemical analysis.
Results Rehydration in injectable PRF showed acidity over time (p < 0.05). A definite pro-angiogenic effect of NM alone was found regarding neo-vessel formation supported by the respective light microscopically analysis without significant differences to PRF alone (p>0.005). This pro-angiogenic effect could not be exaggerated when NM was combined with liquid/solid PRF (each p>0.005).
Conclusions Rehydration with liquid PRF of the collagen membrane results in acidity compared to a saline solution or patient’s blood. The significant pro-angiogenic potential of the membrane alone resulted in enhanced neo-vessel formation that could not be optimized with the addition of PRF.
Static and dynamic adsorption of arsenate from water by Fe3+ complexed with 3-aminopropyltriethoxysilane-modified carboxymethyl chitosan
Authors: Jiang Changjin , Zhang Shuang , Zhang Ting 
Published: October 2023

Abstract

Fe3+ complexed with 3-aminopropyltriethoxysilane (APTES)-modified carboxymethyl chitosan (CMC) named Fe-ACMC was synthesized by a one-step method at room temperature and pressure. The surface morphology and chemical structure of Fe-ACMC were characterized by SEM-EDS, XRD, BET, FT-IR, XPS, and ζ-potential. Both Fe3+ and APTES adsorbed onto the CMC surface. The optimum pH for arsenate [As(V)] adsorption was 3–9 with removal efficiency > 99%. The adsorption of As(V) onto Fe-ACMC could reach equilibrium within 25 min with the maximum adsorption capacity of 84.18 mg g–1. The pseudo-second-order model (R2 = 0.995) fitted well the kinetic data, while the Freundlich model (R2 = 0.979) well described adsorption isotherm of As(V) on Fe-ACMC. The co-existing anions (NO3–, CO32–, and SO42–) exhibited a slight impact on the As(V) adsorption efficiency, whereas PO43– inhibited As(V) adsorption on Fe-ACMC. The real applicability of Fe-ACMC (0.8 g L–1) was achieved to remove ca. 10.0 mg L–1 of As(V) from natural waters to below 0.05 mg L–1. The regeneration and reuse of Fe-ACMC for As(V) adsorption were achieved by adding 0.2 mol L–1 HCl, whereas the adsorption capacity decreased after 5 cycles. The main adsorption mechanism of As(V) on Fe-ACMC was attributed to electrostatic attraction and inner-sphere complexation between –NH2···Fe3+ and As(V). The dynamic adsorption of As(V) onto Fe-ACMC was investigated in a fixed-bed column. Thomas model was the most suitable model to elucidate the dynamic adsorption behavior of As(V). The loading capacity of Fe-ACMC packed column for As(V) was 47.04 mg g–1 at pH 7 with an initial concentration of 60 mg L–1, flow rate of 3 mL min–1, and bed height of 0.6 cm. The excellent performance of Fe-ACMC for adsorption makes it a good candidate for a wide range of applications.
Multiprojection Local Discriminant Analysis
Authors: Ma Jiajun , Zhang Shilong , Xu Fei , Hu Zhijuan 
Published: October 2023

Abstract
Linear discriminant analysis (LDA) is a critical technology for dimensionality reduction (DR). However, LDA still suffers from the following issues. One is that the total number of features available from LDA is limited to the number of classes minus one, which severely limits its application, especially for the problems where the dimension of the features is much higher than the number of classes. Another one is that LDA only preserves the global information of the data while ignoring the local structure of the data, which degrades the performance. To overcome these disadvantages, a multiprojection local discriminant analysis (MLDA) of calculating the discriminant features is proposed in this paper. Specifically, we first make a simple but crucial transformation for the optimization problem of LDA, and then propose a novel multiprojection convex discriminant analysis framework that can extract an unlimited number of features and avoid the small sample size problem. In addition, an auto-optimized graph technology is cleverly integrated into the discriminant analysis framework to exploit the local structure of data. As a result, enough more discriminative and structured features can be extracted. Since two variables need to be optimized simultaneously in the proposed methods, an efficient iterative optimization algorithm is introduced to solve the proposed MLDA. Extensive experiments on several benchmark data sets have demonstrated the effectiveness of the proposed method.
Design of sponge-like chitosan wound dressing with immobilized bacteriophages for promoting healing of bacterially infected wounds
Authors: Sidarenka Anastasiya , Kraskouski Aliaksandr , Savich Viktoryia , Akhmedov Oliy , Nikalaichuk Viktoryia , Herasimovich Aliaksandra , Hileuskaya Kseniya , Kulikouskaya Viktoryia 
Published: October 2023

Abstract
Application of wound dressings loaded with antimicrobial agents considered a viable option to reduce wound bacterial colonization and prevent infection, in order to improve the healing process. In this study, we developed an easy-produced chitosan sponge-like wound dressing containing a broad-host spectrum Escherichia phage BIM BV-67 as an antimicrobial component. This novel dressing was entirely composed of biologically safe and biocompatible materials, had a porous structure, was biodegradable, and exhibited a high swelling capacity. Atomic force microscopy of model layer-by-layer modified planar surfaces and scanning electron microscopy of chitosan sponges showed a non-oriented adsorption and low density of phage particles on chitosan surface. However, immobilized Escherichia phage BIM BV-67 maintained its infectivity and lytic activity. Phage-loaded chitosan sponges effectively inhibited growth of E. coli BIM B-984 G in both qualitative (agar diffusion) and quantitative (suspension) in vitro assays. Moreover, the dressings with bacteriophage retained bactericidal activity for 12 weeks when stored at 4°C. Furthermore, in vivo testing showed that topical application of phage-loaded chitosan sponges significantly reduced the number of E. coli BIM B-984 G cells in the wound and resulted in accelerated wound surface regeneration in infected rats compared to the use of pure sponges and no treatment. Based on these promising results, developed technology has potential as a platform for producing topical dressings with immobilized bacteriophages active against wide range of wound-infecting pathogens. In turn, this could promote the application of phage therapy in wound management.
Pilot-scale production of Bacillus subtilis MSCL 897 spore biomass and antifungal secondary metabolites in a low-cost medium
Authors: Bolmanis Emils , Grigs Oskars , Didrihsone Elina , Senkovs Maris , Nikolajeva Vizma 
Published: October 2023

Abstract

Bacillus subtilis is a plant growth promoting bacterium that acts as a microbial fertilizer and biocontrol agent, providing benefits such as boosting crop productivity and improving nutrient content. It is able to produce secondary metabolites and endospores simultaneously, enhancing its ability to survive in unfavorable conditions and eliminate competing microorganisms. Optimizing cultivation methods for the production of B. subtilis MSCL 897 spores on an industrial scale requires a suitable medium, typically made from food industry by-products, and maintaining optimal temperature and pH levels to achieve high vegetative cell and spore densities with maximum productivity and yield. In this study, we demonstrate successful pilot-scale (100 L bioreactor) production of a biocontrol agent B. subtilis with good spore yields (1.5 x 109 spores/mL) and a high degree of sporulation (> 80%) using a low-cost cultivation media, which showed excellent antifungal activity (1.6–2.3 cm) against several phytopathogenic fungi. An improved methodology for inoculum preparation was investigated to ensure an optimal seed culture state prior to inoculation, promoting process batch-to-batch repeatability. Increasing the molasses concentration in the medium and operating the process in fed-batch mode with additional molasses feed, did not improve the overall spore yield, hence, process operation in batch mode with 10 g/L molasses is preferred. Results also showed that the product quality was not significantly impacted for up to 12 months of storage at room temperature.
Phylogenetic relationship among cultivated and wild species of genus Macrotyloma based on cytology and molecular markers
Authors: Mishra Bhawna , Gautam Manisha , Thakur Nisha , Chahota Rakesh 
Published: October 2023

AbstractThe current study is a pioneering effort to create karyotypes and include comprehensive karyomorphological analysis of two wild species (M. sar-gharwalensisfrom Uttarakhand containing high protein content of 39.5% andM. axillarefrom Australia with significant characters, such as more pods/plant, a larger seed yield/plant, stress tolerance etc.) and one cultivated species (M. uniflorum) of horsegram. For genetic diversity study eight cultivated lines (VLG1, HPKM319, HPKM317, HPKM249, HPKM193, HPK4, HPKM191, HIMGANGA) along with wild species were analyzed with 50 SSRs primers. Cytogenetic markers like secondary constrictions, 45S rDNA and 5S rDNA were established in this study. Over 200 crossing attempts between cultivated and wild species resulted only six F1, which were sterile. The cause of the F1's sterility was identified by studying pollen morphology, meiotic anomalies, and chromosomal data. The phylogenetic tree was drawn from the molecular analysis using DARwin software. All results were in consonance with the other results yielded by Dendogram and Structure analysis. Dendrogram showed thatM. sar-gharwalensisis completely distinct from the cultivated lines, whereasM. axillarefound to be very close to them. HIMGANGA and HPKM193 lines of cultivated species exhibited more resemblance towardsM. axillareas compared to the other species. Molecular characterization and karyotypic studies markedM. axillareas the closest parent of the cultivated horsegram (M. uniflorum). These findings would be extremely beneficial in clarifying the phylogenetic relationships and extending the limited genetic base of the cultivated species of horsegram for further enhancing its nutritional and therapeutic properties.