bluuebunny/crossref_metadata_2025_split huggingface dataset:
Investigation of vitamin D deficiency in girls with growth and development variations—a single center study
Authors: Huang Panwang , Zeng Beilei , Ren Feng , Zhou Yuan , Li Ye , Huang Yinyin , Liu Xingyu , Zhou Jiaxiu , Ma Yaping 
Published: January 2025

PurposeTo understand the status of vitamin D deficiency in girls with growth and developmental variations, as well as the impact of COVID−19 on their vitamin D levels, and to provide reference for the prevention and treatment of vitamin D deficiency in children.MethodsA retrospective analysis was conducted on 1,345 instances of girls with growth and developmental variations who visited our pediatric endocrinology department and completed vitamin D detection. A total of 279 girls with complete data were included in this study. Among them, 246 girls were classified into four groups based on different growth and developmental variations: early puberty group, menarche group, obesity group, short stature group, and 33 healthy girls served as the control group. Besides, the girls were divided into pre-epidemic and post-epidemic groups by the occurrence of the COVID-19 epidemic. Vitamin D were measured in all girls. The 25(OH)D &lt;20 ng/ml was used as the standard for vitamin D deficiency.ResultsThe levels of vitamin D in the early puberty group, menarche group, obesity group, short stature group, and control group were as follows: 20.23 ± 5.90 ng/ml, 17.85 ± 5.69 ng/ml, 21.31 ± 8.99 ng/ml, 27.90 ± 12.27 ng/ml, and 29.42 ± 12.65 ng/ml, respectively. The levels of vitamin D in the early puberty group, menarche group, and obesity group were significantly lower than those in the control group (P &lt; 0.05). The individual vitamin D deficiency rates in the aforementioned groups were 52.07%, 73.91%, 59.46%, 30.95%, and 30.30%, respectively. The vitamin D levels in the pre-epidemic and post-epidemic groups were 20.48 ± 6.22 ng/ml and 22.50 ± 9.74 ng/ml, respectively (P &gt; 0.05).ConclusionGirls with early puberty, menarche, and obesity have a certain deficiency of vitamin D levels, and appropriate vitamin D treatment should be provided clinically. Girls with short stature and healthy girls also have certain levels of vitamin D deficiency, and awareness of prevention should be strengthened.
Ziziphus jujube promotes fertility and pregnancy outcomes in Rat model of uterine adhesions
Authors: Asgharzadeh Fereshteh , Attarian Mahsa , Khazaei Majid , Al-Asady Abdulridha Mohammed , Mansoori Saeide , Naimi Hamideh , Eskandari Moein , Khorrami Azar , Nazari Seyedeh Elnaz , Aminian Akram , Farazastanian Marjaneh , Eshtad Elaheh , Avan Amir , Ryzhikov Mikhail , Hasanzadeh Malihe , Hassanian Seyed Mahdi 
Published: January 2025

IntroductionThe therapeutic efficacy of oral administration of Ziziphus jujube in the context of uterine adhesion (UA) and its impact on pregnancy outcomes was investigated.MethodsIn a rat UA model, Z. jujube was evaluated for its ability to mitigate injury-induced uterine adhesion bands, uterine shortening, and enhance endometrial regeneration. The assessment included analysis of gland numbers, uterine endometrial thickness, and regulation of inflammatory cytokines. The antioxidant properties of Z. jujube were also studied through antioxidant enzyme activity in uterine tissue homogenates. Fibrotic changes were examined through histological Trichrome staining and analysis of pro-fibrotic factors.ResultsTreatment with Z. jujube resulted in a significant reduction in uterine tissue fibrosis, as evidenced by histological evaluation and reduced expression of fibrotic markers. The intervention demonstrated positive outcomes in embryonic development, pregnancy rates, and pregnancy outcomes. Z. jujube effectively inhibited the formation of extra-uterine adhesion bands to internal organs. No toxicity-related morphological changes were observed in vital organs of the Z. Jujube-treated group.DiscussionThe results collectively indicate that Z. jujube is a safe and potent natural product with anti-inflammatory and anti-fibrotic properties, highlighting its potential as a novel candidate for clinical studies targeting UA in patients.
Adverse events in different administration routes of amiodarone: a pharmacovigilance study based on the FDA adverse event reporting system
Authors: Yang Jingrong , You Mengfan , Wang Jingxin , Sun Rongfei , Han Lili , Liu Xiaonan , Niu Kaibin , Xing Kaidi , Sun Juanping , Su Wenge , Wang Yifei 
Published: January 2025

BackgroundArrhythmias are prevalent cardiac disorders with significant impacts on patient quality of life and mortality. Amiodarone, a class III antiarrhythmic agent, is widely used to manage both atrial and ventricular arrhythmias due to its efficacy in prolonging the cardiac action potential and its multiple antiarrhythmic properties. While clinical trials have highlighted the safety and efficacy of amiodarone, there is limited real-world data on adverse events (AEs) associated with different administration routes. This study aims to address this gap by utilizing the U.S. Food and Drug Administration’s Adverse Event Reporting System (FAERS) to investigate the spectrum and timing of AEs related to amiodarone administration through disproportionality analysis and stratification methods.MethodsData from the FAERS database were analyzed using disproportionality analysis and reporting odds ratio (ROR) methods for comparative analysis, and the Weibull distribution for time-to-adverse-event analysis. The study examined data from 2004 through the first quarter of 2024 to analyze adverse event signals and the time of occurrence between intravenous and oral amiodarone administration.ResultsA total of 16,749 records of adverse reactions associated with amiodarone were identified. Among these, 2,412 events were related to intravenous amiodarone, and 8,220 events were related to oral amiodarone. The analysis revealed that cardiac and hepatic AEs were more common with intravenous administration, while pulmonary and thyroid-related AEs were more frequent with oral administration. Furthermore, the onset of adverse reactions varied significantly between the routes. The Weibull distribution analysis showed a median onset time of 5 days for intravenous administration compared to 74 days for oral administration. Both routes exhibited early failure-type signals, indicating a decreasing risk of AEs over time.ConclusionAmiodarone exhibits varying adverse drug reactions and onset times across different routes of administration. Clinicians should carefully consider these differences when selecting the administration route to balance the risks of adverse reactions with therapeutic benefits.
Identifying vital spreaders in large-scale networks based on neighbor multilayer contributions
Authors: Zhu Weiwei , Meng Xuchen , Sheng Jiaye , Zhang Dayong 
Published: January 2025

IntroductionIdentifying influential spreaders in complex networks is crucial for understanding information propagation and disease immunity. The spreading ability of a node has been commonly assessed through its neighbor information. However, current methods do not provide specific explanations for the role of neighbors or distinguish their individual contributions to the spread of information.MethodsTo address these limitations, we propose an efficient ranking algorithm that strictly distinguishes the contribution of each neighbor in information spreading. This method combines the count of common neighbors with the K-shell value of each node to produce its ranking. By integrating these two factors, our approach aims to offer a more precise measure of a node's influence within a network.ResultsExtensive experiments were conducted using Kendall’s rank correlation, monotonicity tests, and the Susceptible-Infected-Recovered (SIR) epidemic model on real-world networks. These tests demonstrated the effectiveness of our proposed algorithm in identifying influential spreaders accurately.DiscussionFurthermore, computational complexity analysis indicates that our algorithm consumes less time compared to existing methods, suggesting it can be efficiently applied to large-scale networks.
Fluctuation in body composition and urine specific gravity of Turkish wrestlers in a top-level official wrestling competition
Authors: Donmez Ersel , Isik Ozkan , Baic Mario 
Published: January 2025

PurposeThis research aimed to examine the fluctuations in body composition and Urine-Specific Gravity (USG) of elite wrestlers in a high-level official wrestling competition.MethodThirty-one wrestlers in the Türkiye Senior Greco-Romen Wrestling national team participated in this research. Wrestlers were divided into weight loss and non-weight loss groups, and changes in their body composition and USG were measured at three different times (beginning of the camp, weigh-in, and before the competition). The duration between the beginning of the camp and the competition weigh-in time was considered as a dehydration process and the duration between the competition weigh-in time and before the competition was regarded as a rehydration process. In the data analysis, 3 × 2 repeated measures ANOVA was used.ResultsIt was determined that during the dehydration process of wrestlers who lost weight, there was a decrease of 4.02%, 2.50%, 14.62%, and 2.66% in body weight, FFM, FM, and TBW, whereas, during the rehydration process, there was a gain of 1.85%, 1.77%, 2.63%, and 1.87%, respectively. In addition, it was determined that wrestlers who lost weight had a 0.87% increase in USG during the dehydration process and a 0.41% decrease in the rehydration process. The results show that wrestlers cannot regain body weight and FM lost in the hydration fluctuation during a competition, but they can regain FFM, TBW, and USG. However, although it was determined that the wrestlers were statistically able to regain FFM, TBW, and USG, they could not return to the levels at the beginning of the camp.ConclusionIt was determined that before a high-level official wrestling competition, wrestlers still preferred weight loss practices and it was determined that they were exposed to fluctuations in their body composition and USG. It is thought that this result may negatively affect the wrestlers’ health and competition performance during a high-level competition.
Optimal calorie restriction threshold: effect of FATmax exercise combined with different proportions of calorie restriction on hypercholesterolemia
Authors: Wu Yuetong , Zhang Li , Li Jing , Xue Boyang , Shang Wenyuan , Lu Yingli 
Published: January 2025

Background/ObjectivesTo evaluate the impact of maximal fat oxidation intensity exercise combined with calorie restriction intervention on lipid-related parameters in a hypercholesterolemic population, and to determine if an optimal range of calorie restriction exists for effectively enhancing blood lipid profiles.MethodsA 4-week intervention study combined exercise and calorie restriction for 64 patients aged 18–60 with secondary hypercholesterolemia. Ultimately, 43 participants completed the study. The dietary intervention adhered to the principles of a balanced diet, with meal plans designed to provide three meals per day for the duration of the study. Each subject’s daily calorie intake was set to match their individual resting energy expenditure (REE) plus varying proportions of physical activity (PA) calories. Participants were divided into four groups based on these proportions: REE only, REE + PA33%, REE + PA67%, and REE + PA100%. FATmax exercises were conducted 5 times per week, lasting 1 h each.Results1) Compared with baseline, subjects’ body weight, fat mass and body fat rate decreased significantly; fat-free mass also decreased significantly in the REE, REE + PA33%, and REE + PA67% groups. 2) Subjects’ serum TC decreased significantly; serum LDL-C and ApoB decreased significantly in the REE, REE + PA33%, and REE + PA67% groups; there were no significant changes in serum HDL-C and ApoA1. 3) Serum PCSK9 was significantly decreased in the REE and the REE + PA 67% groups; serum LDLR was significantly decreased in all groups of subjects. 4) Between the groups, the rate of change in serum LDL-C was significantly different.ConclusionFATmax exercise combined with proper proportions of calorie restriction can significantly decrease serum cholesterol levels and fat mass in hypercholesterolemic patients. Nevertheless, it is misleading to assume that a drastic reduction in calorie intake invariably results in superior outcomes. Optimal cost-effectiveness may be achieved within a calorie restriction range of REE + PA33-67%.
Design and testing of a posture-adjusting precision metering device for high-speed maize planting
Authors: Dong Jianxin , Gao Xiaojun , Zheng Zhouzhou , Zhao Pengfei , Bi Yubin , Huang Yuxiang 
Published: January 2025

IntroductionThis study introduces a new technical method that involves adjusting the seed-filling posture and fluidizing the seed group to improve the capacity of mechanical seed-metering devices for high-speed maize planting. The design of a novel posture-adjusting seed-metering device is presented and its operating principle is described. In the seed-filling area, the seeds maintain the same postural characteristics and are detached from the seed group. This method creates favorable conditions for mechanical seed-metering devices to achieve effective seed-filling under high-speed planting conditions.MethodsFirstly, the key parameters of the core component were analyzed. Secondly, the influences of the seed posture adjusting efficiency and seed flow distribution characteristics on the seed-filling effect were clarified by the EDEM simulation. Finally, the high-speed metering performance was optimized and validated using bench testing.ResultsThe experiment demonstrated that the type A groove had the highest seed posture adjusting efficiency, a more uniform seed flow distribution, and a superior seed-filling effect as compared to the other groove types. The best metering performance was achieved with an opening angle of 21.6° and an opening width of 8.4 mm; this resulted in pass, repeat, and leak rates of 94.8%, 1.3%, and 3.9%, respectively. Within the speed range of 8–14 km/h, the posture-adjusting seed-metering device demonstrated a pass rate of over 94%, a repeat rate below 2.1%, and a leak rate below 3.9%.DiscussionThe designed device had a better high-speed planting capacity than a seed-metering device without a posture-adjusting mechanism, thus proving the effectiveness of the novel seed-filling method. These findings provide a reference for improving the high-speed planting capacity of mechanical seed-metering devices.
Plastid genome comparison and phylogenetic analyses of the Chinese group of medicinal species and related taxa within Asparagus genus
Authors: Xie Pingxuan , Wang Tinglu , Tan Jiawei , Fan Linyuan , Liu Changkun , Yan Hanjing 
Published: January 2025

BackgroundAsparagus L. is a large genus widely distributed across the continents of the Old World. Among its members, approximately 14 species found in China are recognized as popular herbal medicines. However, accurate authentication of these medicinal species and their phylogenetic relationships with related taxa remains unresolved.MethodsTo identify simple sequence repeats (SSRs) and divergence hotspot regions appropriate for future authentication studies, as well as to infer the phylogenetic relationships among Asparagus species, we employed a plastid genome (plastome) dataset consisting of 25 Asparagus species (21 newly sequenced and four retrieved from GenBank), encompassing 12 Chinese medicinal species, for comparative and phylogenetic analyses.ResultsAll Asparagus plastomes displayed a typical quadripartite structure with sizes ranging from 155,948 bp to 157,128 bp and harbored 114 unique genes (80 protein-coding genes, 30 tRNA genes, and four rRNA genes). IRscope and Mauve analyses indicated minimal structural variation among Asparagus plastomes. We detected between 79 to 95 SSRs across the plastomes; most were located in the large single-copy (LSC) region and primarily consisted of mono-nucleotide repeat sequences (especially A and T repeats). The genus displayed mono-, di-, tri-, tetra-, penta-, and hexa-nucleotide repeats, but with variations in types and numbers among different species. Additionally, we identified 12 special SSR motifs and seven divergent hotspot regions that may serve as potential molecular markers for future identification efforts. Phylogenetic analyses yielded a robust phylogeny for Asparagus taxa, which were split into Clades I, II, and III. Notably, medicinal Asparagus species were mainly found in Clade III. Although the phylogenetic relationships of most Asparagus species aligned with previous study findings, the phylogenetic positions of A. munitus, A. subscandens, A. gobicus, and A. dauricus were newly determined.ConclusionsThe plastomes of Asparagus are largely conserved in terms of genome structure, size, gene content, and arrangement. Nevertheless, SSRs analyses revealed significant interspecific polymorphism within Asparagus. In addition, special SSR motifs and divergent hotspot regions identified from Asparagus plastomes provided reference for subsequent identification investigations. The plastome-based phylogeny provided preliminary insights into the relationships among the Chinese group of medicinal species and related taxa within Asparagus. Overall, this study offers a wealth of informative genetic resources pertinent to Asparagus, thereby enhancing our understanding of its evolution and laying a foundation for species identification, assessment of genetic population diversity, as well as the exploration and conservation of germplasm resources.
Kindergarten teachers’ emotional intelligence and surface acting: the chain mediating effects of self-efficacy and work engagement
Authors: Sun Shucun , Yan Zhonglian , Sun Caixia 
Published: January 2025

BackgroundEmotional labor, distinct from physical and mental labor, has gained significant attention in contemporary organizational psychology research. As a strategy for performing emotional labor, surface acting refers to the process of faking emotions to meet the demands of organizations’ norms. This study aimed to investigate the relationship between emotional intelligence and surface acting among Chinese kindergarten teachers, focusing on the mediating role of self-efficacy and work engagement.MethodsIntegrating the conservation of resources theory and the job demands-resources model, a questionnaire survey was conducted among 1,017 Chinese kindergarten teachers using Wong &amp; Law Emotional Intelligence Scale, Self-Efficacy Scale, Utrecht Work Engagement Scale, and Surface Acting Scale. SPSS 26.0 was used to conduct descriptive statistics and correlation tests. Structural equation modeling and mediation analysis were constructed using AMOS 28.0.ResultsThe results showed reveals several key findings. Firstly, kindergarten teachers’ emotional intelligence significantly positively predicted surface acting rather than negatively. Secondly, self-efficacy and work engagement, respectively, mediate the relationship between emotional intelligence and surface acting in kindergarten teachers. Additionally, self-efficacy and work engagement have chain mediating effects in the relationship between kindergarten teachers’ emotional intelligence and surface acting.ConclusionThe research findings reveal the influencing mechanism of kindergarten teachers’ emotional intelligence on surface acting, providing a theoretical basis and practical implications for understanding and promoting the reasonable use of surface acting by kindergarten teachers in the Chinese context.
Personalizing AI tools for second language speaking: the role of gender and autistic traits
Authors: Du Yiran , Wang Chenghao , Zou Bin , Xia Yinan 
Published: January 2025

IntroductionIt is important to consider individual differences in research on educational technology. This study investigates the interplay between autistic traits, gender, and the perception of artificial intelligence (AI) tools designed for second language (L2) speaking practice, contributing to a deeper understanding of inclusive educational technology.MethodsA sample of 111 university students completed the Broad Autism Phenotype Questionnaire (BAPQ) to measure autistic traits (AU) and their sub-traits Aloof (AF), Rigid (RD), and Pragmatic Language (PL). Perceptions of AI tools were assessed across five dimensions: Perceived Usefulness (PU), Perceived Ease of Use (PEOU), Attitude (AT), Behavioral Intention (BI), and Usage Behavior (UB). The study utilized correlation and regression analyses to examine relationships between these variables, while exploring gender-specific moderating effects.ResultsKey findings revealed no significant gender differences in autistic traits or overall perceptions of AI tools. Contrary to expectations, autistic traits were negatively correlated with perceptions of AI tools, suggesting that current AI designs may not adequately support individuals with pronounced autistic traits. Additionally, gender moderated some relationships, with males displaying stronger associations between autistic traits and both PEOU and UB.DiscussionThis research bridges critical gaps by linking neurodiversity and gender to technology acceptance, advancing the field’s understanding of individual differences in AI-based language learning. It underscores the importance of designing personalized and adaptive educational tools that address diverse learner needs, promoting inclusivity and effectiveness in L2 practice.
Case report: Non-linear evolution of oxytocin informs YBOCS changes post-DBS of the bed nucleus of the stria terminalis for treatment resistant OCD
Authors: Belge Jean-Baptiste , Geenen Vincent , Salado Anne L. , Kaschten Bruno , Martin Didier , Scantamburlo Gabrielle 
Published: January 2025

IntroductionObsessive-compulsive disorder (OCD) is a challenging neuropsychiatric condition with a subset of patients remaining refractory to conventional treatments. Deep brain stimulation (DBS) of the bed nucleus of the stria terminalis (BNST) has shown promise for severe, treatment-resistant OCD. This case report examines the relationship between plasma oxytocin levels and OCD symptom severity following BNST-DBS.MethodsA 36-year-old patient with long-standing, treatment-resistant OCD underwent stereotactic implantation of DBS electrodes at the BNST. Postoperative assessments included OCD symptom severity using the Yale-Brown Obsessive Compulsive Scale (YBOCS) and plasma oxytocin levels, measured at 12 time points over three years. Longitudinal and correlational analyses were performed using linear and polynomial regression models.ResultsNon-linear trends in oxytocin levels were identified, with polynomial regression revealing a significant quadratic term, suggesting a parabolic trend. Strong positive correlations were found between changes in oxytocin levels and YBOCS total, obsession, and compulsion scores.ConclusionThe findings suggest a significant non-linear evolution of oxytocin levels and a positive correlation with OCD symptom changes following BNST-DBS. Oxytocin levels could serve as a biomarker for DBS efficacy if this finding is replicated in larger studies.