bluuebunny/crossref_metadata_2025_split huggingface dataset:
Mn-single-atom nano-multizyme enabled NIR-II photoacoustically monitored, photothermally enhanced ROS storm for combined cancer therapy
Authors: Wang Xiaozhe , Ren Xiaofeng , Yang Jie , Zhao Zican , Zhang Xiaoyu , Yang Fan , Zhang Zheye , Chen Peng , Li Liping , Zhang Ruiping 
Published: December 2023

Abstract

Rationale
To realize imaging-guided multi-modality cancer therapy with minimal side effects remains highly challenging.

Methods
We devised a bioinspired hollow nitrogen-doped carbon sphere anchored with individually dispersed Mn atoms (Mn/N-HCN) via oxidation polymerization with triton micelle as a soft template, followed by carbonization and annealing. Enzyme kinetic analysis and optical properties were performed to evaluate the imaging-guided photothermally synergized nanocatalytic therapy.

Results

Simultaneously mimicking several natural enzymes, namely peroxidase (POD), catalase (CAT), oxidase (OXD), and glutathione peroxidase (GPx), this nano-multizyme is able to produce highly cytotoxic hydroxyl radical (•OH) and singlet oxygen (
1
O
2
) without external energy input through parallel and series catalytic reactions and suppress the upregulated antioxidant (glutathione) in tumor. Furthermore, NIR-II absorbing Mn/N-HCN permits photothermal therapy (PTT), enhancement of CAT activity, and photoacoustic (PA) imaging to monitor the accumulation kinetics of the nanozyme and catalytic process in situ. Both in vitro and in vivo experiments demonstrate that near-infrared-II (NIR-II) PA-imaging guided, photothermally enhanced and synergized nanocatalytic therapy is efficient to induce apoptosis of cancerous cells and eradicate tumor tissue.

Conclusions
This study not only demonstrates a new method for effective cancer diagnosis and therapy but also provides new insights into designing multi-functional nanozymes.

Graphical Abstract
Prevalence, knowledge, awareness, and attitudes towards dietary supplements among Bahraini adults: a cross-sectional study
Authors: Allehdan Sabika , Hasan Mariam , Perna Simone , Al-Mannai Mariam , Alalwan Tariq , Mohammed Duha , Almosawi Mohamed , Hoteit Maha , Tayyem Reema 
Published: December 2023

AbstractThe usage of dietary supplements (DS) is a global trend that is likely influenced by sociodemographic variables and body weight status. Some individuals utilize supplements in the hopes that they may enhance their health and prevent illness. Main objective of this study is to assess knowledge and awareness about using DS among Bahraini adults. This cross-sectional study was conducted using snowball sampling method, in which an electronic self-administrative questionnaire was used to collect information from 582 eligible participants. Data about socio-demographic characteristics, anthropometric measurements, knowledge, awareness, and attitudes toward using DS was collected from each participant. Prevalence of DS use was high (59.3%) and most of users were females. Most DS users (87.5%) thought that DS are safe (P < 0.001). The DS users were significantly more likely than non-users to believe that DS can prevent and treat chronic and communicable diseases, as well as the DS having side effects (P < 0.05). The most frequently consumed DS were vitamin D (29.5%) and vitamin C (26.4%). The main purpose of using DS among the DS users was to treat nutrient deficiency and around 60% of them used DS based on physician’s prescription. In conclusion, the using of DS was highly prevalent among younger adult females with normal body weight. The findings of this study emphasize the need for implementing public educational programs about safe and proper use of DS.
Graphical Abstract
Polymers of low concern? Assessment of microplastic particles used in 3D printing regarding their toxicity on Raphidocelis subcapitata and Daphnia magna
Authors: Kühnel Dana , Steska Tim , Schlich Karsten , Wolf Carmen , Wohlleben Wendel , Hund-Rinke Kerstin 
Published: December 2023

AbstractThe potential effects of microplastic particle exposure on environmental organisms has sparked intense research activities. Various studies have been conducted, however on a limited set of mostly pristine polymer materials. In parallel to the ongoing research activities, it is discussed to include non-natural polymers into the registration process under REACH. Currently, non-natural polymers are exempted from registration, based on the general assumption of being non-hazardous due to their high molecular weight. In addition, the extensive number of polymers exceeding the registration capacities was mentioned as a reason for exemption. Hence, relevant polymers requiring a registration shall be selected according to specific criteria that help to identify those with a concern for hazardous effects. In the line of these developments we here present the results of a systematic ecotoxicity testing of 16 microplastic particles of different polymer composition, part of which are micronized polymer powders used in 3D printing (intentionally produced primary microplastic, losing particle shape by the 3D printing). All polymer materials were systematically varied and extensively characterised with regard to their properties (e.g. particle size, cross-linking, molar mass distribution, end groups, reactivity). Most of the polymers exerted toxicity in 48 h acute Daphnia magna immobilisation assay and 72 h chronic Raphidocelis subcapitata growth inhibition assay, except one PA and one HDPE material showing toxicity in D. magna, and one HDPE material showing toxicity in green algae. From these results we conclude that none of the microplastic particles studied here, independent of their polymer properties, give raise to concern for hazardous effects.
Treatment with psychostimulants and atomoxetine in people with psychotic disorders: reassessing the risk of clinical deterioration in a real-world setting
Authors: Corbeil Olivier , Brodeur Sébastien , Courteau Josiane , Béchard Laurent , Huot-Lavoie Maxime , Angelopoulos Elaine , Di Stefano Samanta , Marrone Erica , Vanasse Alain , Fleury Marie-Josée , Stip Emmanuel , Lesage Alain , Joober Ridha , Demers Marie-France , Roy Marc-André 
Published: December 2023

BackgroundAlthough attention-deficit hyperactivity disorder (ADHD) is often comorbid with schizophrenia spectrum and other psychotic disorders (SZSPD), concerns about an increased risk of psychotic events have limited its treatment with either psychostimulants or atomoxetine.AimsTo examine whether the risk of hospital admission for psychosis in people with SZSPD was increased during the year following the introduction of such medications compared with the year before.MethodThis was a retrospective cohort study using Quebec (Canada) administrative health registries, including all Quebec residents with a public prescription drug insurance plan and a diagnosis of psychotic disorder, defined by relevant ICD-9 or ICD-10 codes, who initiated either methylphenidate, amphetamines or atomoxetine, between January 2010 and December 2016, in combination with antipsychotic medication. The primary outcome was time to hospital admission for psychosis within 1 year of initiation. State sequence analysis was also used to visualise admission trajectories for psychosis in the year following initiation of these medications, compared with the previous year.ResultsOut of 2219 individuals, 1589 (71.6%) initiated methylphenidate, 339 (15.3%) amphetamines and 291 (13.1%) atomoxetine during the study period. After adjustment, the risk of hospital admission for psychosis was decreased during the 12 months following the introduction of these medications when used in combination with antipsychotics (adjusted HR = 0.36, 95% CI 0.24–0.54; P < 0.0001).ConclusionsThese findings suggest that, in a real-world setting, when used concurrently with antipsychotic medication, methylphenidate, amphetamines and atomoxetine may be safer than generally believed in individuals with psychotic disorders.
Stratification of Atherosclerosis based on Plasma Metabolic States
Authors: Menaker Yuval , van den Munckhof Inge , Scarpa Alice , Placek Katarzyna , Brandes-Leibovitz Rachel , Glantzspiegel Yossef , Joosten Leo A B , Rutten Joost H W , Netea Mihai G , Gat-Viks Irit , Riksen Niels P 
Published: December 2023

Abstract

Context
Atherosclerosis is a dominant cause of cardiovascular disease (CVD), including myocardial infarction and stroke.

Objective
To investigate metabolic states that are associated with the development of atherosclerosis.

Methods
Cross-sectional cohort study at a university hospital in the Netherlands. A total of 302 adult subjects with a body mass index (BMI) ≥ 27 kg/m2 were included. We integrated plasma metabolomics with clinical metadata to quantify the “atherogenic state” of each individual, providing a continuous spectrum of atherogenic states that ranges between nonatherogenic states to highly atherogenic states.

Results
Analysis of groups of individuals with different clinical conditions—such as metabolically healthy individuals with obesity, and individuals with metabolic syndrome—confirmed the generalizability of this spectrum; revealed a wide variation of atherogenic states within each condition; and allowed identification of metabolites that are associated with the atherogenic state regardless of the particular condition, such as gamma-glutamyl-glutamic acid and homovanillic acid sulfate. The analysis further highlighted metabolic pathways such as catabolism of phenylalanine and tyrosine and biosynthesis of estrogens and phenylpropanoids. Using validation cohorts, we confirmed variation in atherogenic states in healthy subjects (before atherosclerosis plaques become visible), and showed that metabolites associated with the atherogenic state were also associated with future CVD.

Conclusion
Our results provide a global view of atherosclerosis risk states using plasma metabolomics.
The Influence of Maternal High Fat Diet During Lactation on Offspring Hematopoietic Priming
Authors: Kim Katherine , Varghese Mita , Sun Haijing , Abrishami Simin , Bowers Emily , Bridges Dave , Meijer Jennifer L , Singer Kanakadurga , Gregg Brigid 
Published: December 2023

Abstract
Obesity and metabolic diseases are rising among women of reproductive age, increasing offspring metabolic risk. Maternal nutritional interventions during lactation present an opportunity to modify offspring outcomes. We previously demonstrated in mice that adult male offspring have metabolic impairments and increased adipose tissue macrophages (ATM) when dams are fed high fat diet (HFD) during the postnatal lactation window (HFD PN). We sought to understand the effect of HFD during lactation on early-life inflammation.
HFD PN offspring were evaluated at postnatal day 16 to 19 for tissue weight and gene expression. Profiling of adipose tissue and bone marrow immune cells was conducted through lipidomics, in vitro myeloid colony forming unit assays, and flow cytometry.
HFD PN mice had more visceral gonadal white adipose tissue (GWAT) and subcutaneous fat. Adipose tissue RNA sequencing demonstrated enrichment of inflammation, chemotaxis, and fatty acid metabolism and concordant changes in GWAT lipidomics. Bone marrow (BM) of both HFD PN male and female offspring had increased monocytes (CD45+Ly6G−CD11b+CD115+) and B cells (CD45+Ly6G−CD11b−CD19+). Similarly, serum from HFD PN offspring enhanced in vitro BM myeloid colonies in a toll-like receptor 4-dependent manner. We identified that male HFD PN offspring had increased GWAT pro-inflammatory CD11c+ ATMs (CD45+CD64+).
Maternal exposure to HFD alters milk lipids enhancing adiposity and myeloid inflammation even in early life. Future studies are needed to understand the mechanisms driving this pro-inflammatory state of both BM and ATMs, the causes of the sexually dimorphic phenotypes, and the feasibility of intervening in this window to improve metabolic health.
A Paradoxical Convergence: French Economists and the Policy toward Cartels from the 1870s to the Eve of the Great Depression
Authors: Spector David 
Published: December 2023

Abstract
As in other industrialized countries, cartelization was widespread in France after the 1870s. Cartels, and the public policy toward them, were frequently addressed in the public debate. This article deals with the stance taken by French economists on this subject until the Great Depression. Although they were divided into several groups that were in sharp disagreement on most scientific and policy issues, French economists were almost united in their lack of support for anticartel policy. The liberal economists' opposition stemmed from their general hostility to government intervention. Unlike in the English-speaking world, where many economists otherwise critical of government gradually became supportive of antitrust after mounting evidence had revealed the scope of certain kinds of exclusionary behavior, the French liberal economists remained constant in their opposition. The more reform-minded university professors, as well as the sociologists- economists of the Durkheimian school, were unenthusiastic about policies meant to safeguard competition because they viewed “excessive” market competition as destabilizing and wasteful. Finally, the most prominent experts in industrial economics, who were employed by large companies or professional organizations, also advocated a hands-off approach, in accordance with their employers' preferences.
Was It a “Fatal Error”? Sraffa and Samuelson on Marshall's Partial Equilibria Method
Authors: Salvadori Neri , Signorino Rodolfo 
Published: December 2023

Abstract
Sraffa's “On the Relations between Cost and Quantity Produced” (1925) and Samuelson's “An Exact Hume-Ricardo-Marshall Model of International Trade” (1971) presented a strikingly similar analytical argument regarding the theoretical domain of Marshallian partial equilibrium models. Yet they reached radically different conclusions from their analyses. This article addresses this theoretical puzzle and proposes a plausible solution. To this end, the article reconstructs the evolution of Sraffa's and Samuelson's thinking on Marshallian partial equilibrium analysis and the evolution of Samuelson's thinking regarding Sraffa's 1926 critique of Marshallian economics. Sraffa's unpublished manuscripts to which Samuelson did not have access during his lifetime are carefully examined. A change in Sraffa's assessment of Marshallian partial equilibrium methodology that occurred in the second half of the 1920s is highlighted. This leads to new insights into Sraffa's thinking on the role and significance of the case of constant costs within Marshallian economics.
Sarcolipin relates to fattening, but not sarco/endoplasmic reticulum Ca2+-ATPase uncoupling, in captive migratory gray catbirds
Authors: Elowe Cory R. , Stager Maria , Gerson Alexander R. 
Published: December 2023

ABSTRACT
In order to complete their energetically demanding journeys, migratory birds undergo a suite of physiological changes to prepare for long-duration endurance flight, including hyperphagia, fat deposition, reliance on fat as a fuel source, and flight muscle hypertrophy. In mammalian muscle, SLN is a small regulatory protein which binds to sarco/endoplasmic reticulum Ca2+-ATPase (SERCA) and uncouples Ca2+ transport from ATP hydrolysis, increasing energy consumption, heat production, and cytosolic Ca2+ transients that signal for mitochondrial biogenesis, fatigue resistance and a shift to fatty acid oxidation. Using a photoperiod manipulation of captive gray catbirds (Dumetella carolinensis), we investigated whether SLN may play a role in coordinating the development of the migratory phenotype. In response to long-day photostimulation, catbirds demonstrated migratory restlessness and significant body fat stores, alongside higher SLN transcription while SERCA2 remained constant. SLN transcription was strongly correlated with h-FABP and PGC1α transcription, as well as fat mass. However, SLN was not significantly correlated with HOAD or CD36 transcripts or measurements of SERCA activity, SR membrane Ca2+ leak, Ca2+ uptake rates, pumping efficiency or mitochondrial biogenesis. Therefore, SLN may be involved in the process of storing fat and shifting to fat as a fuel, but the mechanism of its involvement remains unclear.
Paradojas de las prácticas productivas artísticas alternativas en el paradigma del arte contemporáneo
Authors: Mayo Vega Luis Manuel 
Published: December 2023

Las nuevas prácticas artísticas alternativas que cuestionan el mercado artístico y las políticas culturales actuales se enfrentan a contradicciones porque el paradigma moderno conserva agentes con capital simbólico cuando el paradigma contemporáneo del arte posmoderno se desgasta; verbigracia, las galerías garaje son moda y no alternativa económica. Cada componente del sistema productivo del arte (entendido como un proceso comunicativo) contiene paradojas: 1. Artistas rebeldes integrados en la paradoja permisiva de las instituciones culturales; 2. Contenidos fringe artistificados enmarcados en una estética exótica global neocolonial; 3. Mercado secundario artístico –subastas- con mayor capital simbólico y económico que el mercado primario –galerías de arte-, lo que provoca estrategias de mercado elitistas y ofelimitadas entre sus artistas estrellas; 4. Públicos deambulantes se empoderan haciendo cola ante el museo contemporáneo y cuestionan la definición de arte como bien de mérito. El flamante Studio RFG de Madrid es nuestro caso de estudio.
Study of Bi-functional Applications of ZnO Nanoparticles Synthesized via Sonochemical Route
Authors: Raghupathy D.A. , Ramgopal G. , Kumar V.G. Dileep , Kumar T. Naveen , Ravikumar C.R. 
Published: December 2023

The sonochemical synthesis involved the dispersion of zinc oxide (ZnO) precursor in a suitable solvent, followed by ultrasonic irradiation to induce chemical reactions and nucleation of ZnO nanoparticles. The resulting nanomaterials exhibited a uniform particle size distribution, which is crucial for their photocatalytic efficiency. ZnO nanoparticles with a uniform particle size of 25 nm were successfully synthesized using a sonochemical route and were employed for the degradation of direct green and fast orange dyes under UV light irradiation. The band gap of the ZnO nanoparticles was determined to be 3.35 eV, indicating its potential as a photocatalyst for dye degradation. The degradation efficiency of the dyes was evaluated by monitoring the change in their concentration over time. The ZnO nanoparticles demonstrated excellent photocatalytic activity, efficiently degrading both dyes within a relatively short duration. The electrochemical studies further confirmed the potential applicability of the synthesized ZnO nanoparticles in various electrochemical systems. The ZnO electrode that was produced could detect lead in an acidic solution. The ZnO electrode is a promising electrode material for making sensor applications because of its higher electrochemical behaviour. Overall, this research contributes to the development of efficient and environmentally friendly approaches for wastewater treatment and lead sensor.
Problems of Mine Construction and Mechanization of Coal Mining in the Kemerovo Mine during the First Five-Year Plan
Authors: Morozov N.M. 
Published: December 2023

The problems ofmine construction and mechanization of technological processes at the Kemerovo mine are considered - one of the main ways to increase the volume of coal production provided for by the plans of the the first five-year plan. During 1928-1932 it was planned to build six large mines there. There is an unsatisfactory provision of their construction in the required amount of financial and material resources, without preliminary accounting for the state of the soils, careful geological exploration of reserves. The facilities construction was carried out in a artisanal way without machines and mechanisms, without observing safety precautions. Based on the situation, production problems, including poor organization of labor, were not solved quickly enough in the current regime.
With an improvement in the level of mechanization of underground work and the commissioning of the mine "Pioneer" in the last year of the five-year period at the mine significantly (by 135%) the volume of coal production increased. The factor holding it back was still the problem of the lack of mechanization in many labor-intensive jobs, both on the surface and in underground mines, as well as the general unsatisfactory level of qualification of miners.
Pengaruh Kegiatan Pemasaran di Media Sosial, Ulasan Elektronik dari Mulut ke Mulut, dan Penyokong Selebriti terhadap Niat Membeli dengan Kesadaran Merek sebagai Variabel Intervening (Studi Kasus pada Scarlett Whitening di Kalangan Generasi Z Kota Semarang
Authors: Amartya Dewi , Santosa Suryono Budi 
Published: December 2023

This study aims to analyze the effect of social media marketing activities, electronic word of mouth, celebrity endorsement, and brand awareness on purchasing intention making (a study on Scarlett Whitening in Generation Z Semarang City), as well as to find out the variables that most influence purchasing intention so that it can be an overview in making strategies to increase purchasing intention for Scarlett Whitening. This research was conducted for residents residing in Semarang. The number of samples in this study were 114 respondents with the criteria being active Instagram users that knowing and had visited @scarlett_whitening before who are 17 – 27 years old and domiciled in Semarang City. The data collection method used in this study is through a questionnaire. This study uses Structural Equation Modeling (SEM) as an analytical tool. The results of this study indicate that social media marketing activities has a positive and significant effect on brand awareness, electronic word of mouth has a positive and significant effect on brand awareness, celebrity endorsement has a positive and significant effect on brand awarenes, brand awareness has a positive and significant effect on purchase intention. In other hand, social media marketing activities, electronic word of mouth, and celebrity endorsement have no effect on purchase intention.
ContTune: Continuous Tuning by Conservative Bayesian Optimization for Distributed Stream Data Processing Systems
Authors: Lian Jinqing , Zhang Xinyi , Shao Yingxia , Pu Zenglin , Xiang Qingfeng , Li Yawen , Cui Bin 
Published: December 2023

The past decade has seen rapid growth of distributed stream data processing systems. Under these systems, a stream application is realized as a Directed Acyclic Graph (DAG) of operators, where the level of parallelism of each operator has a substantial impact on its overall performance. However, finding optimal levels of parallelism remains challenging. Most existing methods are heavily coupled with the topological graph of operators, unable to efficiently tune under-provisioned jobs. They either insufficiently use previous tuning experience by treating successively tuning independently, or explore the configuration space aggressively, violating the Service Level Agreements (SLA).To address the above problems, we propose ContTune, a continuous tuning system for stream applications. It is equipped with a novel Big-small algorithm, in which the Big phase decouples the tuning from the topological graph by decomposing the job tuning problem into sub-problems that can be solved concurrently. We propose a conservative Bayesian Optimization (CBO) technique in the Small phase to speed up the tuning process by utilizing the previous observations. It leverages the state-of-the-art (SOTA) tuning method as conservative exploration to avoid SLA violations. Experimental results show that ContTune reduces up to 60.75% number of reconfigurations under synthetic workloads and up to 57.5% number of reconfigurations under real workloads, compared to the SOTA method DS2.