bluuebunny/crossref_metadata_2025_split huggingface dataset:
Incidence of posterolateral tibia plateau fractures and concomitant injuries in Chinese patients who underwent an anterior cruciate ligament reconstruction
Authors: Jiang Shijie , Zhu Ruixia , Jia Xiaojun , Zheng Dong , Wang Yuji , Xu Wei , Cheng Rongshan , Dimitriou Dimitris , Ren Weizhi 
Published: December 2023

Abstract

Objective
The purpose of the present study was to report the incidence and classify the morphological subtypes of posterolateral tibial plateau fractures accompanying anterior cruciate ligament (ACL) tears in an East China population, as well as to evaluate the implications of such injuries on the functional recovery following ACL reconstruction.
Methods
488 cases of patients treated for ACL rupture between January 2016 and June 2020 were retrospectively reviewed, and their posterolateral tibial plateau fractures were classified based on MRI assessment. Functional outcomes were evaluated at a two-year postoperative follow-up using a range of validated scoring systems.
Results
The study identified a high incidence of posterolateral tibial plateau fractures (41.6%) among ACL injury cases, with type ⅢA and ⅢB fractures occurring more frequently. Patients with high-grade fractures experienced significantly lower functional recovery than those with low-grade injuries. Major findings included noncontact mechanism predominance in ACL injuries, a higher occurrence rate of type ⅢA and ⅢB fractures among older females, and a substantial association with meniscal and medial collateral ligament tears.
Conclusions
The incidence and distinct morphological classification of posterolateral tibial plateau fractures are clinically significant in ACL injury cases. The higher grade posterotibial plateau fractures are associated with worse functional outcomes in patients undergoing an ACLR.
Feasibility, perceived aesthetic outcomes and patients’ interest in transoral endoscopic thyroidectomy (TOETVA) in a cohort of patients in the Thames Valley United Kingdom
Authors: Puttergill Brooke , Asher Cyra , Yarwood William , Down Billy , Everson James , Mihai Radu 
Published: December 2023

Abstract
Introduction: Thyroid surgery techniques without visible scar have grown internationally with little traction in the UK. The aim was to assess the perception of neck scar after thyroid surgery, estimate the feasibility for transoral endoscopic thyroidectomy (TOETVA) and define the public demand for scarless thyroidectomy.
Methods: A mixed cohort study approved by national ethics committee assessed retrospectively the feasibility of TOETVA based on current guidelines. A standardised questionnaire used Manchester Scar Scale (MSS) and explored patient-centred outcomes and views.
Results: Out of 265 patients (75% women, median age 56 years) who underwent thyroid lobectomy for indeterminate nodules (n=160) or proven low-risk thyroid cancer (n=105), 64% would have been suitable for TOETVA, including 49% of cancers.
Of 92 respondents, MSS was excellent (25%), good (56%; MSS<7) or poor (15%; MSS > 10). Negative scar perception preoperatively resulted in poor MSS scores post operatively (p<0.0001). Poor MSS impacted all individuals regardless of preoperative neck scar concerns (p<0.001). Worse MSS scores were significant in patients with complications or cancer recurrence concerns (p<0.002) independent of age (p=0.065) and gender (p=0.7118). Need for thyroid hormone replacement in 34% of patients didn’t correlate with to MSS.
Patients’ interest in scarless technique didn’t correlate with MSS and appeared to be attributable to personal values, geographic accessibility, and intensity of aversion to complication (p<0.05). Overall, 29% of patients would consider a scarless technique and 31% opposed the idea.
Conclusion: This study population showed comparable interest and feasibility for scarless thyroid surgery as international populations. How to respond to this need will become apparent in the coming years.
Examining Physiological Features Underlying Team Coordination Breakdowns
Authors: Eijndhoven Kyana H. J. van , Wiltshire Travis J. , Hałgas Elwira A. , Gevers Josette M. P. , Louwerse Max 
Published: December 2023

Abstract

Team coordination breakdowns (TCBs) generally reflect episodes of ineffective team functioning, resulting in suboptimal team performance. Computational identification of TCBs enables us to examine the underlying characteristics of suboptimal performance, and to potentially deliver real-time feedback to teams. Especially in time-critical crisis situations, such feedback can be invaluable. Previous studies found difficulties in distinguishing between coordination patterns that indicate TCBs, and patterns that might indicate other aspects of teamwork. Subsequently, we examined features capturing underlying characteristics of team coordination, based on multiple physiological signals and coordination measures, to identify TCBs. Our multi-methodological approach allowed us to identify features that are important for TCB identification. We also observed that distributions of feature data related and unrelated to TCBs were significantly different, indicating that the features captured underlying patterns in team coordination data. In addition, our results indicated that team performance, measured as goal achievement duration, is more severely compromised when TCBs last longer. By showing a relationship between TCBs and goal achievement duration, as well as understanding the key features of these TCBs, our study contributes to deepening our understanding of TCBs, and supporting effective team functioning and performance.
The Ability to Predict the Progression of the Change in Oct Angiography Values in the Visional Field and Retina Nerve Layer Tomography in Patients With Glaucoma Progress
Authors: Demir Süleyman , KÖYLÜ MEHMET TALAY 
Published: December 2023

Abstract
INTRODUCTION: To examine the ability of changes in optical coherence tomography angiography (OCTA) values to predict progression in the visual field (GA) and retinal nerve fiber layer (RNFL) in patients with glaucoma progression. METHODS: All patients in the glaucoma outpatient clinic of SBU Gülhane Medical Faculty between 2021–2023 underwent RNFL, 24:2 GA and simultaneous peripapillary OCT-A. 130 eyes that progressed were included in the study. Thinning of more than 5 µ in any quadrant in the RNFL or a decrease of more than 1 dB in the MD value in the visual field within 6 months was accepted as a progression criterion. The ability of changes in OCTA-RNFL and OCTA radial peripapillary capillary plexus (RPCP) analysis to predict progression in RNFL and GA was prospectively investigated. RESULTS: The mean age of the patients was 66.9 ± 11.8 years. There was progression in GA in 70 eyes and RNFL in 89 eyes between baseline and 6-month controls. The ability to predict the progression of the change in OCTA-RNFL in the superior, inferior, nasal, temporal and total quadrants was not sufficient (p = 0.55, 0.40, 0.84, 0.91, 0.39, respectively). Changes in OCTA-RNFL values failed to predict GA MD progression in the superior, inferior, nasal, temporal, and total quadrants (p = 0.40,0.11,0.24,0.44, and 0.10, respectively). The ability of the change in OCT-A Radial Peripapillary Capillary Plexus (RPCP) values to predict progression in the RNFL failed to show superiority in the superior, inferior, nasal, temporal and total quadrants (respectively p = 0,21,0,53,0,39,0,39, 0.29). The ability of the change in OCT-A RPCP values to predict progression in GA failed to show superiority in the superior, inferior, nasal, temporal, and total quadrants (p = 0.96,0.29,0,77,0.42, 0.21, respectively). DISCUSSION AND CONCLUSION: Although OCT-A is a non-invasive imaging test whose use and popularity have been increasing in recent years; In our study could not show superiority compared to RNFL and GA tests in demonstrating glaucoma progression.
Lessons on integrated chronic care organisation of primary care during the COVID-19 pandemic: case study analyses in Cambodia, Slovenia, and Belgium
Authors: Danhieux Katrien , Martens Monika , Chhim Srean , Mihevc Matic , Yem Sokunthea , Susič Antonija Poplas , Damme Wim Van , Masquillier Caroline , Wouters Edwin , Olmen Josefien van 
Published: December 2023

Abstract
Background
During the COVID-19 pandemic, people living with Noncommunicable diseases (NCDs) were at double risk: developing severe COVID-19 and developing complications from not having their chronic condition(s) well controlled. Primary Health Care (PHC) is paramount for integrated care of chronic diseases, but was severely restrained during the pandemic. Our aim was to examine how the organisation of PHC for chronic diseases was affected by the pandemic, and as such, shine a light on strengths, weaknesses, and opportunities in different types of health systems.
Methods
Semi-structured interviews with 69 participants were carried out in three countries with different primary health care systems: a developing health system in a lower middle-income country (Cambodia); a centrally steered health system in a high-income country (Slovenia); and a publicly funded highly privatised health-care health system in a high-income country (Belgium). Both PHC providers and macro-level stakeholders were interviewed by the international team. An inductive thematic analysis was performed.
Results
In all three countries the workload of the staff was high and shifted towards pandemic related tasks, affecting availability for chronic care. It also created space for innovations such as telemedicine. In general, recognition of the importance of PHC increased. But also considerable differences between the three countries’ health care systems have been uncovered. In Cambodia medicines are lacking but a strong civil servant ethos is present. In Slovenia strong leadership appeared to be an important strength, but flexibility of PHC workers was limited. This flexibility and entrepreneurship turned out to be valuable in Belgium, but there fragmentation of PHC was a barrier.
Conclusions
Moments of crisis and disruption lay bare the structural agility and gaps more clearly, as a magnifying glass. In Cambodia, there is a need to sustainable supply of medicines. In Slovenia, the shortage of general practitioners (GPs) needs attention. In Belgium, rethinking of the PHC practice organisation is needed. Our analyses provide the opportunity to analyze and build back stronger health care systems.
Intrahousehold Conflict Effects on Domestic Violence in Rwanda: Evidence from the Demographic and Health Survey 2019-2020
Authors: Harerimana Jean de Dieu 
Published: December 2023

Abstract
Background
Domestic violence affects approximately one-third of women globally and presents unique challenges in Rwanda. This study examined the link between domestic violence and household conflicts, focusing on infertility, unintended pregnancies, and the impact of premarital pregnancies. The survey uses data from the 2019/20 Rwanda Demographic and Health Survey and addresses the influence of Rwandan cultural norms, the prevalence of child marriage, and societal attitudes toward violence.
Methodology
This study analysed data from the 2019-20 Rwanda Demographic and Health Survey using a two-stage sampling process. Regression discontinuity design (RDD) and logistic regression were used to evaluate variables such as domestic violence incidence and age, as well as control variables such as education, marital status, and occupational status.
Results
The findings indicate increased risks of domestic violence as women approaching the legal marriage age of 21 years face increased risks of domestic violence, with 35.1% greater likelihoods of physical violence and 14.8% greater odds of sexual violence. Polygamous marriages significantly increase the risk of sexual violence by 26.5%. Early forced sexual encounters intensify the likelihood of physical and sexual violence by 67.5% and 129.7%, respectively.
Conclusion
This study highlights the increased vulnerability to physical and sexual violence linked to early sexual encounters and polygamous marriage. These findings, diverging from global trends, underscore the necessity of employing Rwanda-specific strategies. Moreover, to effectively address domestic violence, it is important to consider cultural dynamics, socioeconomic status, and matrimonial education, including sex education and bargaining power, for both parties.
Safavid and Ottoman Chanfrons: Re-examining the Attributions of Remaining Chanfrons
Authors: Ghafari Sanaz , Hashemi Gholamreza 
Published: December 2023

Abstract
Art is always intertwined with society and human activities like politics and trade. In ancient times, equipping armies for conquest or territorial defense was vital, with the state of horses on the battlefield being crucial for victory. Alongside soldiers and commanders, the horses were equipped with protective gear like chanfron. Beyond the craft and artistic inclinations in making Islamic motifs and patterns, these artifacts had visual and symbolic significance on the battlefield. Although historical records do not provide precise details about the origins of chanfrons, this type of equine armor became prevalent in various civilizations, including the Ottomans and Safavids, during the 15th to 17th centuries. This study aimed to compare Safavid and Ottoman chanfrons, delving into different aspects. Unlike the limited Safavid examples, displaying common visual traits, the Ottoman ones, constituting a reasonable statistical population, exhibit distinct differences, indicating a lack of unity and accepted artistic style. Moreover, some Ottoman chanfrons bear a striking resemblance to Safavid ones, raising questions about this similarity. The research aimed to understand why certain Ottoman chanfrons resemble the Safavid examples, despite their non-uniformity. The research methodology employed descriptive, comparative, and analytical studies, utilizing archival and field research methods. The objective was to challenge the certainty of their attributions, emphasizing the need for further investigations. Determining the exact origin of chanfrons remains beyond the scope of this study. Overall, despite their current attributions, some artifacts may have been created by Safavid artists and later labeled as Ottoman art due to various circumstances.
Human Resource Management in Policing Fraud
Authors: Dirin Dirin , Handriatmo Yuyun Arief Kus , Kesuma Dicky Irawan , Setyawan Nugroho Ari 
Published: December 2023

The paper draws on the roles of Human Resource Management (HRM) in policing fraud by the Indonesian Nation Police (INP). The methods of this study is a literature review and document analysis. This research find that HRM has a role in policing fraud through 1) recruitment, 2) education, 3) use/development, 4) maintenance and 5) termination from the office. HRM is pottentially essential for improving police professionalism. Further, the HRM success application may cause the success of bureaucracy and governance reform for corruption prevention in the INP. Moreover, operational policing fraud can be improved by reliable HRM practice. Ultimately, this paper suggests a further empirical study to explore HRM in policing andits role in policing fraud.
Reassessment of Radiation Exposure From Bone Scintigraphy
Authors: Tanyildizi-Kökkülünk Handan , Şenişik Ahmet Murat , Yüksel Mahmut 
Published: December 2023

Aim:
This study was aimed to re-determine the radiation dose rate emitted from the patients who underwent
bone scintigraphy.

Material and Methods:
A mean of 20.87±2.54 mCi 99mTc-MDP was injected into patients. A GM counter was
used to measure dose rates in 3 different periods, at intervals of 25, 50, 100, 150, and 200 cm from the patient's
anterior for head, thorax, abdomen, and pelvis levels. Measurements were used to determine patient-induced
environmental doses and radiation doses to personnel/patient relatives.

Results and Discussion:
There were strong correlations between mean dose rate (mRh-1mCi-1) and time at all
regions and distances. The received dose for staff was calculated between a range of 0.01-0.02 mSv/mCi per
patient. The total dose to be received by the companion was estimated to be between 0.019-0.039 and
0.011-0.022 mSv for public and personal vehicle transportation, respectively. The radiation dose exposed by
nurses (4th, 6th, and 8th hours after injection) was found to be 0.012-0.064, 0.006-0.038, and 0.002-0.018
mSv/patient, respectively.

Conclusion:
The fact that the doses of personnel and patient relatives in the study were below the legal limits
shows that the study was carried out within a safe range. However, in terms of radiation protection, it is necessary
to limit the time spent with the patient as much as possible and increase the distance. Since the dangers of
low radiation dosages are unknown, there is a need to inform the patient's relatives and staff about the potential
risks.
Uncovering the Impact of Aggrephagy in the Development of Alzheimer's
Disease: Insights Into Diagnostic and Therapeutic Approaches from
Machine Learning Analysis
Authors: Xu Jiayu , Gou Siqi , Huang Xueyuan , Zhang Jieying , Zhou Xuancheng , Gong Xiangjin , Xiong Jingwen , Chi Hao , Yang Guanhu 
Published: December 2023

Background:
Alzheimer's disease (AD) stands as a widespread neurodegenerative disorder
marked by the gradual onset of memory impairment, predominantly impacting the elderly.
With projections indicating a substantial surge in AD diagnoses, exceeding 13.8 million individuals
by 2050, there arises an urgent imperative to discern novel biomarkers for AD.

Methods:
To accomplish these objectives, we explored immune cell infiltration and the expression
patterns of immune cells and immune function-related genes of AD patients. Furthermore, we
utilized the consensus clustering method combined with aggrephagy-related genes (ARGs) for typing
AD patients and categorized AD specimens into distinct clusters (C1, C2). A total of 272 candidate
genes were meticulously identified through a combination of differential analysis and
Weighted Gene Co-Expression Network Analysis (WGCNA). Subsequently, we applied three machine
learning algorithms-namely random forest (RF), support vector machine (SVM), and generalized
linear model (GLM)-to pinpoint a pathogenic signature comprising five genes associated
with AD. To validate the predictive accuracy of these identified genes in discerning AD progression,
we constructed nomograms.

Results:
Our analyses uncovered that cluster C2 exhibits a higher immune expression than C1.
Based on the ROC(0.956). We identified five characteristic genes (PFKFB4, PDK3, KIAA0319L,
CEBPD, and PHC2T) associated with AD immune cells and function. The nomograms constructed
on the basis of these five diagnostic genes demonstrated effectiveness. In the validation group,
the ROC values were found to be 0.760 and 0.838, respectively. These results validate the robustness
and reliability of the diagnostic model, affirming its potential for accurate identification of
AD.

Conclusion:
Our findings not only contribute to a deeper understanding of the molecular mechanisms
underlying AD but also offer valuable insights for drug development and clinical analysis.
The limitation of our study is the limited sample size, and although AD-related genes were identified
and some of the mechanisms elucidated, further experiments are needed to elucidate the more
in-depth mechanisms of these characterized genes in the disease.
Cordia Dichotoma: A Comprehensive Review of its Phytoconstituents and Endophytic Fungal Metabolites and their Potential Anticancer Effects
Authors: Patil Saurav Madhavrao , Bhattacharya Sankha 
Published: December 2023

Abstract:
Cordia dichotoma is a valuable medicinal plant belonging to the family Boraginaceae. It consists of several beneficial secondary metabolite components, including alkaloids, carbohy-drates, flavonoids, glycosides, saponins, and tannins. Numerous studies have been conducted to assess the anticancer properties of Cordia dichotoma on MCF-7, A-549, PC3, and HeLa cancer cell lines, primarily utilizing ethanolic extract, methanolic extract, and chloroform extract. The results of these studies have demonstrated significant effects. Furthermore, several studies have revealed the rich phytoconstituent content of Cordia dichotoma with some significant components previously utilized by researchers to investigate the anticancer properties of specific compounds. This review discusses several of these components, including β-sitosterol, α-amyrin, Quercitrin, Robinin, betulin, Taxifolin, and Hesperetin. Additionally, a recent study uncovered that the anti-cancer effect of metabolites from endophytic fungi residing on the Cordia dichotoma plant is attributed to a property of the plant itself. This review focuses on the current state of anticancer research related to this plant and its components.
Lipoprotein (a) as a Biomarker for Cardiovascular Diseases and Potential
New Therapies to Mitigate Risk
Authors: Mukherjee Debabrata , Nissen Steven E 
Published: December 2023

Background:
Lipoprotein (a) [Lp(a)] is a molecule that induces inflammation of the blood
vessels, atherogenesis, valvular calcification, and thrombosis.

Methods:
We review the available evidence that suggests that high Lp(a) levels are associated with a
persisting risk for atherosclerotic cardiovascular diseases despite optimization of established risk
factors, including low-density lipoprotein cholesterol (LDL-C) levels.

Observations:
Approximately a quarter of the world population have Lp(a) levels of >50 mg/dL (125
nmol/L), a level associated with elevated cardiovascular risk. Lifestyle modification, statins, and
ezetimibe do not effectively lower Lp(a) levels, while proprotein convertase subtilisin/kexin type 9
(PCSK-9) inhibitors and niacin only lower Lp(a) levels modestly. We describe clinical studies suggesting
that gene silencing therapeutics, such as small interfering RNA (siRNA) and antisense oligonucleotide
targeting Lp(a), offer a targeted approach with the potential for safe and robust Lp(a)-
lowering with only a few doses (3-4) per year. Prospective randomized phase 3 studies are ongoing to
validate safety, effectiveness in improving hard clinical outcomes, and tolerability to assess these
therapies.

Conclusion:
Several emerging treatments with robust Lp(a)-lowering effects may significantly lower
atherosclerotic cardiovascular risk.