bluuebunny/crossref_metadata_2025_split huggingface dataset:
The Impact of Social Media Use on Sleep and Mental Health in Youth: a Scoping Review
Authors: Yu Danny J. , Wing Yun Kwok , Li Tim M. H. , Chan Ngan Yin 
Published: February 2024

Abstract
Purpose of Review
Social media use (SMU) and other internet-based technologies are ubiquitous in today’s interconnected society, with young people being among the commonest users. Previous literature tends to support that SMU is associated with poor sleep and mental health issues in youth, despite some conflicting findings. In this scoping review, we summarized relevant studies published within the past 3 years, highlighted the impacts of SMU on sleep and mental health in youth, while also examined the possible underlying mechanisms involved. Future direction and intervention on rational use of SMU was discussed.

Recent Findings
Both cross-sectional and longitudinal cohort studies demonstrated the negative impacts of SMU on sleep and mental health, with preliminary evidence indicating potential benefits especially during the COVID period at which social restriction was common. However, the limited longitudinal research has hindered the establishment of directionality and causality in the association among SMU, sleep, and mental health.

Summary
Recent studies have made advances with a more comprehensive understanding of the impact of SMU on sleep and mental health in youth, which is of public health importance and will contribute to improving sleep and mental health outcomes while promoting rational and beneficial SMU. Future research should include the implementation of cohort studies with representative samples to investigate the directionality and causality of the complex relationships among SMU, sleep, and mental health; the use of validated questionnaires and objective measurements; and the design of randomized controlled interventional trials to reduce overall and problematic SMU that will ultimately enhance sleep and mental health outcomes in youth.
FXR-FGF19 signaling in the gut–liver axis is dysregulated in patients with cirrhosis and correlates with impaired intestinal defence
Authors: Simbrunner Benedikt , Hofer Benedikt S. , Schwabl Philipp , Zinober Kerstin , Petrenko Oleksandr , Fuchs Claudia , Semmler Georg , Marculescu Rodrig , Mandorfer Mattias , Datz Christian , Trauner Michael , Reiberger Thomas 
Published: February 2024

Abstract
Background and aims
Experimental studies linked dysfunctional Farnesoid X receptor (FXR)-fibroblast growth factor 19 (FGF19) signaling to liver disease. This study investigated key intersections of the FXR-FGF19 pathway along the gut–liver axis and their link to disease severity in patients with cirrhosis.

Methods
Patients with cirrhosis undergoing hepatic venous pressure gradient measurement (cohort-I n = 107, including n = 53 with concomitant liver biopsy; n = 5 healthy controls) or colonoscopy with ileum biopsy (cohort-II n = 37; n = 6 controls) were included. Hepatic and intestinal gene expression reflecting FXR activation and intestinal barrier integrity was assessed. Systemic bile acid (BA) and FGF19 levels were measured.

Results
Systemic BA and FGF19 levels correlated significantly (r = 0.461; p < 0.001) and increased with cirrhosis severity. Hepatic SHP expression decreased in patients with cirrhosis (vs. controls; p < 0.001), indicating reduced FXR activation in the liver. Systemic FGF19 (r = −0.512, p < 0.001) and BA (r = −0.487, p < 0.001) levels correlated negatively with hepatic CYP7A1, but not SHP or CYP8B1 expression, suggesting impaired feedback signaling in the liver. In the ileum, expression of FXR, SHP and FGF19 decreased in patients with cirrhosis, and interestingly, intestinal FGF19 expression was not linked to systemic FGF19 levels. Intestinal zonula occludens-1, occludin, and alpha-5-defensin expression in the ileum correlated with SHP and decreased in patients with decompensated cirrhosis as compared to controls.

Conclusions
FXR-FGF19 signaling is dysregulated at essential molecular intersections along the gut–liver axis in patients with cirrhosis. Decreased FXR activation in the ileum mucosa was linked to reduced expression of intestinal barrier proteins. These human data call for further mechanistic research on interventions targeting the FXR-FGF19 pathway in patients with cirrhosis.
Clinical trial number: NCT03267615

Graphical abstract
Physiology of enterohepatic FXR-FGF19 signaling and its regulation in patients with advanced chronic liver disease (ACLD). (FXR) farnesoid X receptor; (FGF19) fibroblast growth factor 19; (BA) bile acids; (c/dACLD) compensated/decompensated advanced chronic liver disease; (FXR) farnesoid X receptor; (SHP) small heterodimer partner; (OST-α/-β) organic solute transporter subunit alpha/beta; (CYP7A1) cholesterol 7 alpha-hydroxylase; (NTCP) Na+-taurocholate cotransporting polypeptide; (CYP8B1) sterol 12-alpha-hydroxylase; (HVPG) hepatic venous pressure gradient; (TJ) tight junctions; (AMP) antimicrobial peptides; (ASBT) Apical Sodium Dependent Bile Acid Transporter; (ZO 1) zonula occludens-1; (OCLN) occluding; (DEFA5) alpha-5-defensin.
A Hessian-Dependent Functional With Free Boundaries and Applications to Mean-Field Games
Authors: Correa Julio C. , Pimentel Edgard A. 
Published: February 2024

AbstractWe study a Hessian-dependent functional driven by a fully nonlinear operator. The associated Euler-Lagrange equation is a fully nonlinear mean-field game with free boundaries. Our findings include the existence of solutions to the mean-field game, together with Hölder continuity of the value function and improved integrability of the density. In addition, we prove the reduced free boundary is a set of finite perimeter. To conclude our analysis, we prove a$$\Gamma $$Γ-convergence result for the functional.
Rare oncogenic alterations in NSCLC—focus on atypical EGFR mutations
Authors: Sharapova Yana , Loges Sonja , Janning Melanie 
Published: February 2024

SummaryIn non-small cell lung cancer (NSCLC), mutations within the epidermal growth factor receptor (EGFR) gene are very common driver mutations. EGFR tyrosine kinase inhibitors (TKIs), have shown remarkable efficacy in patients with common classical EGFR mutations (L858R and exon 19 deletions). However, the landscape becomes intricate with atypical (also known as uncommon) EGFR mutations, comprising up to 30% of cases. This brief review provides an insight into recent studies, shedding light on the challenges and opportunities posed by uncommon mutations. The exploration encompasses clinical outcomes, treatment responses, and innovative approaches such as structure-based classifications, offering insights into the evolving paradigm of precision medicine for NSCLC patients with diverse EGFR mutations.
Numerical Treatment of a Two-Parameter Singularly Perturbed Elliptic Problem with Discontinuous Convection and Source Terms
Authors: Shiromani Ram , Shanthi Vembu , Ramos Higinio 
Published: February 2024

Abstract
In this paper, we address a two-parameter singularly perturbed convection-reaction-diffusion 2-D problem. We also consider that the convection and source terms are discontinuous in space. Due to these discontinuities and the presence of perturbation parameters, solutions to such problems show boundary and interior layers. In this study, we have carried out a numerical approach using a finite-difference technique with an appropriate layer-adapted piecewise uniform Shishkin mesh. Some examples are presented which show the best performance of the proposed method and its agreement with the theoretical analysis.
Response of runoff to climate change in the Manas River Basin flow-producing area, Northwest China
Authors: Gu Xinchen , Long Aihua , He Xinlin , Wang Hao , Lai Xiaoying , Pang Ning , Liu Huan , Yu Haoran 
Published: February 2024

AbstractThe inland river basins of northwestern China are structured as mountain-basin systems. Water resources originate in the flow-producing area (FPA), are utilized and operated in the oasis area and are dissipated in the desert area. In this study, a Soil and Water Assessment Tool (SWAT) model was constructed in the Manas River Basin (MRB) FPA. Meanwhile, it simulated climate change and runoff evolution trends in the FPA of the MRB under different four climate change scenarios of Coupled Model Intercomparison Project Phase 5. The main findings showed that (1) the years 1979–1980 were chosen as the model warm-up period, 1979–2000 as the model calibration period and 2001–2015 as the model validation period to complete the construction of the SWAT model for MRBFPA. From 1981 to 2015, three performance parameters indicated that the model accuracy meets the requirements (NSE = 0.81, R2 = 0.81 and PBIAS = 1.44) and can be used for further studies; (2) the hydrological elements (e.g. runoff, potential evapotranspiration, evapotranspiration, soil water content, snowmelt) in the MRBFPA were analysed by the constructed SWAT model; (3) the climate change in the MRBFPA is close to the RCP 8.5 scenario, and the future changes in water resources under this scenario will range from 659 to 2308 (million)m3. Compared to the multi-year historical mean value (12.95 × 108 m3), the future fluctuation in the amount of water resources available in this basin is increasing.
S4D-ECG: A Shallow State-of-the-Art Model for Cardiac Abnormality Classification
Authors: Huang Zhaojing , Herbozo Contreras Luis Fernando , Yu Leping , Truong Nhan Duy , Nikpour Armin , Kavehei Omid 
Published: February 2024

Abstract
Purpose
This study introduces an algorithm specifically designed for processing unprocessed 12-lead electrocardiogram (ECG) data, with the primary aim of detecting cardiac abnormalities.

Methods
The proposed model integrates Diagonal State Space Sequence (S4D) model into its architecture, leveraging its effectiveness in capturing dynamics within time-series data. The S4D model is designed with stacked S4D layers for processing raw input data and a simplified decoder using a dense layer for predicting abnormality types. Experimental optimization determines the optimal number of S4D layers, striking a balance between computational efficiency and predictive performance. This comprehensive approach ensures the model's suitability for real-time processing on hardware devices with limited capabilities, offering a streamlined yet effective solution for heart monitoring.

Results
Among the notable features of this algorithm is its strong resilience to noise, enabling the algorithm to achieve an average F1-score of 81.2% and an AUROC of 95.5% in generalization. The model underwent testing specifically on the lead II ECG signal, exhibiting consistent performance with an F1-score of 79.5% and an AUROC of 95.7%.

Conclusion
It is characterized by the elimination of pre-processing features and the availability of a low-complexity architecture that makes it suitable for implementation on numerous computing devices because it is easily implementable. Consequently, this algorithm exhibits considerable potential for practical applications in analyzing real-world ECG data. This model can be placed on the cloud for diagnosis. The model was also tested on lead II of the ECG alone and has demonstrated promising results, supporting its potential for on-device application.
Quality of stapled mesenteric defect closure influences the chance of reopening after laparoscopic Roux-en-Y gastric bypass surgery
Authors: Bruinsma F. F. E. , van der Burg S. J. C. , El Adel S. , Schouten R. , Smeets S. J. M. 
Published: February 2024

AbstractInternal herniation (IH) is a common problem after laparoscopic Roux-en-Y gastric bypass surgery (RYGB). Routine closure of the mesenteric defects (MDs) reduces the risk of IH. Only very few articles report on risk factors for IH or describe detailed closing techniques. There is no consensus yet on the best closing method. The objective of this study is to determine the optimal stapling method for closure of MDs after RYGB. All performed RYGB procedures in our high-volume bariatric institute were included. Quality of the closure was scored in the categories poor, sub-optimal, and optimal, to see if the quality of the closure would predict the chance of reopening of the MDs and, therefore, the chance of IH. During any type of laparoscopy in the follow-up of the patient, the conditions of the MDs were stated, for example during diagnostic laparoscopy in symptomatic patients suspicious for IH or during laparoscopic cholecystectomy. Technically well-executed closure of Petersen’s space (PS) with two rows of staples had a greater chance of still being closed upon re-inspection compared to closure with one row (odds ratio = 8.1; 95% confidence interval [1.2–53.2], p = 0.029). Optimal closure of the MD at the jejuno-jejunostomy (JJ-space, JJS) resulted in more closed JJSs upon re-inspection compared to sub-optimal closure (odds ratio = 3.6 [CI 95% 0.8–16.1], p = 0.099). Non-optimally closed MDs had higher reopening rates and, therefore, pose an additional risk for IH. Our classification provides a quality assessment of MD closure during RYGB and gives insight into how to optimize surgical technique.
Effect of PV Plant on Frequency Stability in IEEE12 Bus System for Different Penetration Levels and Depth of Frequency Support
Authors: Çavdar Bora , Akyazi Ömür , Şahin Erdinç , Nuroğlu Mehmet 
Published: February 2024

AbstractThe utilization of renewable energy sources, particularly large-scale photovoltaic plants (PVPs), has been increasing in power systems. However, the high penetration of PVPs in power systems has implications for the system's moment of inertia and frequency response. Therefore, it is crucial to thoroughly investigate the impact of PVPs on system frequency. This study focuses on investigating the effects of a large-scale PVP at various penetration levels on frequency and the depth of frequency support. The study proposes a strategy aimed at maximizing power generation from PVPs while also providing support to system frequency. To assess the effects of PVPs, the study examines events such as load outages, generator outages, load changes, and three-phase short circuits. Additionally, the relationship between voltage and frequency during these events is considered, with the load represented by an impedance model. By studying the depth of frequency support alongside different penetration levels, the study provides a detailed understanding of the impact of PVPs on frequency. The study aims to determine the threshold at which the penetration level of PVPs becomes significant in terms of frequency support. This analysis sheds light on the point at which the presence of PVPs begins to exert a notable influence on frequency stability and support within the power system. Overall, the study contributes to the integration of PVPs in power systems by providing insights into their impact on frequency dynamics and proposing strategies to enhance power generation and frequency support simultaneously.
Flow and hardening behavior in the heat-affected zone of welded ultra-high strength steels
Authors: Afkhami Shahriar , Amraei Mohsen , Javaheri Vahid , Ghafouri Mehran , Björk Timo , Salminen Antti , Zhao Xiao-Lin 
Published: February 2024

AbstractThe applications of thermomechanically processed ultra-high strength steels (UHSS) are rapidly increasing, and welding these UHSSs seems inevitable in steel structures. However, welding heat causes unwanted microstructural transformations in the heat-affected zone (HAZ). Due to the localized nature of these changes throughout the HAZ, evaluating the true stress–strain values of these localized HAZ subzones is essential to improve the accuracy of analytical or numerical models. Hence, this study utilized experimental thermal simulations to replicate HAZ subzones of two types of UHSSs, i.e., direct-quenched S960 and quenched-and-tempered S1100, and employed tensile test in conjunction with digital image correlation to plot the true stress–strain and hardening curves of the subzones. Both UHSSs manifested similar trends but with various fluctuations in their hardening capacities throughout their HAZ subzones. Next, hardening parameters from Hollomon, Voce, and Kocks-Mecking approaches were extracted by fitting the experimental results with the semi-empirical equations. For both UHSS types, the Voce approach, on average, was more accurate in modeling the plastic deformation. Also, hardening parameters achieved via the Voce approach’s fittings agreed with the parameters from Kocks-Mecking plots; this consistency pointed to the predictability of the plastic flow and hardening behavior of both UHSS types. According to the microstructural investigations, the hardening behavior of the investigated HAZ subzones depended on two types of microstructure constituents: ferritic and lath-like features. Ferritic features dominantly governed the plastic flow and hardening near the fusion line, while by getting distant from the fusion line, the lath-like features became more dominant.
Rationing in an Era of Multiple Tight Constraints: Is Cost-Utility Analysis Still Fit for Purpose?
Authors: Dakin Helen , Tsiachristas Apostolos 
Published: February 2024

AbstractCost-utility analysis may not be sufficient to support reimbursement decisions when the assessed health intervention requires a large proportion of the healthcare budget or when the monetary healthcare budget is not the only resource constraint. Such cases include joint replacement, coronavirus disease 2019 (COVID-19) interventions and settings where all resources are constrained (e.g. post-COVID-19 or in low/middle-income countries). Using literature on health technology assessment, rationing and reimbursement in healthcare, we identified seven alternative frameworks for simultaneous decisions about (dis)investment and proposed modifications to deal with multiple resource constraints. These frameworks comprised constrained optimisation; cost-effectiveness league table; ‘step-in-the-right-direction’ approach; heuristics based on effective gradients; weighted cost-effectiveness ratios; multicriteria decision analysis (MCDA); and programme budgeting and marginal analysis (PBMA). We used numerical examples to demonstrate how five of these alternative frameworks would operate. The modified frameworks we propose could be used in local commissioning and/or health technology assessment to supplement standard cost-utility analysis for interventions that have large budget impact and/or are subject to additional constraints.
Recent advances in ocular lubrication
Authors: Zhang Jianhua , Su Yunjuan , Wu Jian , Wang Hongdong 
Published: February 2024

AbstractThe ocular lubrication, where the eyelid constantly slides on the curved corneal surface, is considered as one of primary lubrication systems in bio-tribology. Under reliable lubrication conditions, sensitive ocular tissues remain intact from fatigue damage during spontaneous blink cycles. The tear film, evenly filled between cornea and conjunctiva, is a biological fluid with dynamic adjustment ability, which provides superior lubrication with the friction coefficient of below 0.01. However, the lubrication failure may result in a variety of uncomfortable symptoms such as inflammatory reactions, tissue damage and neurological abnormalities. Therefore, it is essential to clarify the fundamental mechanism of ocular lubrication, which helps to alleviate and even recover from various ocular symptoms. This review firstly demonstrates that the ocular components, containing lipids and mucins, contribute to maintaining the lubrication stability of tear film. Furthermore, the ocular lubrication state in various physiological environments and the physical effect on tear film dynamics are further discussed. As typical applications, the therapeutic agents of dry eye syndrome and contact lens with superior lubrication effects are introduced and their lubrication mechanisms are clarified. Finally, this review summarizes a series of the latest research inspired by ocular lubrication. Overall, this work will provide a valuable guidance on the theoretical research and extensive applications in the field of biological lubrication.
Nano friction behaviour between magnetic materials and copper considering the inter-diffusion effect
Authors: Li Zilin , Dou Lisha , Yang Shiyu , Ouyang Huajiang , Zhu Qichen , Chen Xiaoyang , Jia Xin , Dou Shuaiwei , Cui Xiaolong , Zhang Yudong , Qiu Jingjiang , Qi Guochen , Nie Bangbang , Liu Pan , Wei Ronghan 
Published: February 2024

AbstractCopper, permalloy, cobalt, and silicon are the materials that have been widely utilised in magnetic devices. When the size of interest is down to the nanoscale, the inter-diffusion between certain materials becomes influential. This paper studies the nanoscale friction characteristics between frictional pairs with and without inter-diffusion properties through the atomic force microscope. The distinct evolution features of nanoscale friction force when inter-diffusion is involved are discovered experimentally, which is also confirmed through theoretical analysis. Firstly, through the thin film deposition method, four pairs of contact materials (Cu–Ni81Fe19, Si–Ni81Fe19, Cu–Co, Cu–Si) are designed for friction tests, in which diffusion occurs at the interface of Cu–Ni81Fe19 pair. Then, the effects of sliding velocity and loading force on the nano friction of each pair are measured. It is found that regardless of the diffusion phenomenon: (1) the adhesion force values exhibit a notable correlation to the values of the friction force; (2) the friction force in all four material pairs consistently increases with the growth of the normal loading force, although the growth rate may differ. In terms of the sliding velocity effect, the friction forces of immiscible materials (Si–Ni81Fe19, Cu–Co, and Cu–Si) are found to increase with the increasing sliding velocity. However, the friction force of Cu–Ni81Fe19, decreases with the increasing sliding velocity. Furthermore, a compositive friction model considering both the velocity and the normal force effect was proposed, which shows good agreement with the experimental results and explains the nano friction behaviour of both miscible and immiscible metals.
Modeling and analysis for material removal and surface roughness in fluid jet polishing of optical glass
Authors: Cao Zhongchen , Wang Ming , Liu Haitao , Huang Tian 
Published: February 2024

AbstractFluid jet polishing (FJP) is a non-contact polishing technology that can fabricate free-form optical surfaces with sub-micron-level form accuracy and nano-level surface roughness, especially for hard and brittle materials. The surface generation model of FJP can be used to guide the determination and optimization of process parameters and is of great significance for understanding the evolution mechanism of surface microtopography. However, predictive models for the microscopic topography of polished surfaces are still lacking. This study established a macroscopic surface profile model for predicting 3D material removal characteristics and surface texture by combining the 3D computer fluid dynamics (CFD) simulation model and single-particle erosion mechanism. A fractal theory-based erosion model has been built to calculate the material removal caused by the erosion of a single abrasive particle on the rough surface; thus, it predicts the micro-topography and surface roughness of the polished samples. A series of polishing experiments were conducted to analyze the feasibility and accuracy of the model quantitatively and study the influence mechanism of process parameters on the material removal characteristics and surface quality. Results indicated that the models could well predict material removal and surface roughness. The prediction accuracy of the surface roughness Ra and maximum removal depth is better than 91.6% and 90%, respectively. It is also found that the material removal rate of FJP could reach 0.517 mm3/min, and the surface roughness convergence rate could reach 62.9%.