bluuebunny/crossref_metadata_2025_split huggingface dataset:
Propriospinal myoclonus: A motor phenomenon found in restless legs syndrome different from periodic limb movements during sleep
Authors: Vetrugno Roberto , Provini Federica , Plazzi Giuseppe , Cortelli Pietro , Montagna Pasquale 
Published: July 2005

AbstractThree patients presented with a 25‐, 15‐, and 5‐year history of restless legs syndrome (RLS) and periodic limb movements during sleep (PLMS). For 1, 4, and 5 years, they reported additional involuntary trunk and limbs jerks preceding falling asleep and occasionally during intrasleep wakefulness. Videopolysomnography revealed jerks during relaxed wakefulness arising in axial muscles with a caudal and rostral propagation at a slow conduction velocity, characteristic of propriospinal myoclonus (PSM). Jerk‐related EEG–EMG back‐averaging did not disclose any preceding cortical potential. During relaxed wakefulness preceding falling asleep and during intrasleep wakefulness, PSM coexisted with motor restlessness and sensory discomfort in the limbs. PSM disappeared when spindles and K‐complexes appeared on the EEG. At this time, typical PLMS appeared every 20 to 40 seconds, especially during light sleep stages. PLMS EMG activity was limited to leg, especially tibialis anterior muscles, and did not show propriospinal propagation. In one patient, alternating leg muscle activation was also present. Jerks with a PSM pattern represent another motor phenomenon associated with RLS and different from the more usual PLMS. © 2005 Movement Disorder Society
Acute pathological laughter
Authors: Okuda Darin T. , Chyung Abraham S.C. , Chin Cynthia T. , Waubant Emmanuelle 
Published: July 2005

AbstractPseudobulbar affect is a condition characterized by uncontrollable episodes of inappropriate laughing or crying that are disproportionate and discordant to the situation at hand. We report on a 16‐year‐old woman presenting with acute pathological laughter in the context of CNS demyelinating disease. Brain MRI scans fortuitously obtained before and after the onset of this symptom demonstrated acute gadolinium‐enhancing lesions in the cerebral peduncles. The etiology of this condition remains theoretical; however, the results here provide further insights into the pathways of emotional control. © 2005 Movement Disorder Society
Burden of illness in Parkinson's disease
Authors: Huse Daniel M. , Schulman Kathy , Orsini Lucinda , Castelli‐Haley Jane , Kennedy Sean , Lenhart Gregory 
Published: July 2005

AbstractThis study quantifies direct medical care costs for individual patients with Parkinson's disease (PD) and projects total national costs of PD. Anonymous, patient‐level data on health care utilization and cost were obtained from Medstat's MarketScan Research Databases. Patients were selected for study if they had either two instances of a diagnosis of PD or one diagnosis and two or more prescriptions for PD‐related medication. A control group of persons without PD was selected for comparison. Total annual health care utilization and costs were calculated for both PD patients and controls. A total of 20,016 patients with PD were identified and followed up for an average of 853 days. The mean age of the patients was 73.6 years, and 51.2% were women. Total annual direct costs were $23,101 (SD 27,529) per patient with PD versus $11,247 (SD 16,486) for controls. The regression‐adjusted incremental direct cost of PD versus control was $10,349 (95% confidence interval, 9,053, 11,645). Adding $25,326 in indirect costs, and multiplying by 645,000 cases of PD in the United States, the total cost to the nation is projected to be $23 billion annually. This estimate is higher than most previous studies, with important implications for health care delivery systems worldwide. © 2005 Movement Disorder Society
Antony van Leeuwenhoek and the description of diaphragmatic flutter (respiratory myoclonus)
Authors: Larner Andrew J. 
Published: July 2005

AbstractThis article reviews the first account of diaphragmatic flutter, published by Antony van Leeuwenhoek, the renowned microscopist, in 1723. The completeness of the clinical description merits the eponymous description of Leeuwenhoek's disease. © 2005 Movement Disorder Society
Neuropathic scapuloperoneal syndrome (Davidenkow's syndrome) with chromosome 17p11.2 deletion
Authors: Verma Ashok 
Published: July 2005

AbstractThe nosologic boundary of neuropathic scapuloperoneal syndrome (Davidenkow's syndrome) remains ill defined and its genetic basis is unknown. A case of Davidenkow's syndrome with the monochromosomic 17p11.2 deletion that often is associated with hereditary neuropathy with liability to pressure palsies (HNPP) is described. The other allele at chromosome 17p11.2 locus was of normal length, and direct sequencing of the coding region of the peripheral nerve protein‐22 gene in this allele revealed no additional mutation. The deleted allele in the proband was inherited from the paternal line in which the affected members had a late onset Charcot–Marie–Tooth type 1 clinical phenotype. This observation suggests that the rare Davidenkow's syndrome is clinically related to HNPP and its genotype could be a chromosome 17p11.2 deletion. Muscle Nerve, 2005
Dose‐dependent apoptotic and necrotic myocyte death induced by the β2‐adrenergic receptor agonist, clenbuterol
Authors: Burniston Jatin G. , Chester Neil , Clark William A. , Tan Lip‐Bun , Goldspink David F. 
Published: July 2005

AbstractWe have investigated the dose‐ and time‐dependency of myocyte apoptosis and necrosis induced by the β2‐adrenergic receptor agonist, clenbuterol, with the aim of determining whether myocyte apoptosis and necrosis are two separate processes or a continuum of events. Male Wistar rats were administered subcutaneous injections of clenbuterol, and immunohistochemistry was used to detect myocyte‐specific apoptosis and necrosis. Myocyte apoptosis peaked 4 h after, and necrosis 12 h after, clenbuterol administration. In the soleus, peak apoptosis (5.8 ± 2.0%; P < 0.05) was induced by 10 μg and peak necrosis (7.4 ± 1.7%; P < 0.05) by 5 mg.kg−1 clenbuterol. Twelve hours after clenbuterol administration, 73% of damaged myocytes labeled as necrotic, 27% as apoptotic and necrotic, and 0% as purely apoptotic. Administrations of clenbuterol (10 μg.kg−1) at 48‐h intervals induced cumulative myocyte death over 8 days. These data show that the phenotype of myocyte death is dependent on the magnitude of the insult and the time at which it is investigated. Only very low doses induced apoptosis alone; in most cases apoptotic myocytes lysed and became necrotic and the magnitude of necrosis was greater than that of apoptosis. Thus, it is important to investigate both apoptotic and necrotic myocyte death, contrary to the current trend of only investigating apoptotic cell death. Muscle Nerve, 2005
TP53 mutations are associated with a particular pattern of genomic imbalances in breast carcinomas
Authors: Kleivi Kristine , Diep Chieu B , Pandis Nikos , Heim Sverre , Teixeira Manuel R , Lothe Ragnhild A 
Published: July 2005

AbstractTP53 mutations play an important role in the development of several cancers and are present in 20–40% of all breast carcinomas, contributing to increased genomic instability. In order to address the relationship of mutated TP53 to genomic complexity, the present study analysed 61 breast carcinomas for TP53 mutations and compared mutation status with the pattern of genomic imbalances as assessed by comparative genomic hybridization (CGH). Twenty per cent of the present series of breast carcinomas harboured TP53 mutations. An increasing number of abnormalities, as identified by CGH (higher genomic complexity), correlated significantly with mutant TP53. Among the chromosome arms most commonly altered (in more than 20% of the tumours), loss of 8p and gain of 8q were associated with TP53 mutations, whereas loss of 16q was associated with wild‐type TP53. By performing supervised hierarchical clustering analysis of the CGH data, a cluster of chromosome imbalances was observed that showed differences between wild‐type and mutant TP53 cases. Among these, loss of chromosome arm 5q revealed the strongest correlation with altered TP53. To investigate further the most commonly deleted region of 5q, gene expression patterns from two publicly available microarray data sets of breast carcinomas were evaluated statistically. The expression data sets identified potential target genes, including genes involved in ubiquitination and the known TP53 target CSPG2. The genomic complexity of breast carcinomas as assessed by CGH is associated with TP53 mutation status; breast cancers with TP53 mutations display more complex genomes than do those with wild‐type TP53. The pattern of genomic imbalances associated with mutant TP53 is non‐random, with loss of chromosome arm 5q being particularly closely associated with TP53 mutations. Copyright © 2005 Pathological Society of Great Britain and Ireland. Published by John Wiley & Sons, Ltd.
Mutation analysis of SBDS in pediatric acute myeloblastic leukemia
Authors: Majeed Fidel , Jadko Sergiy , Freedman Melvin H. , Dror Yigal 
Published: July 2005

AbstractBackgroundShwachman–Diamond syndrome (SDS) is associated with a high risk of myelodysplasia, acute myeloid leukemia (AML), and chromosome 7 abnormalities. Ninety percent of SDS patients have mutations in SBDS on 7q11. Herein, we studied the role of genetic alterations in SBDS in AML.ProcedureDNA was extracted from marrows of SDS patients with AML, as well as from children with de novo AML. Direct sequencing of PCR amplified genomic DNA was performed using specific primers flanking each exon. To study whether SBDS heterozygosity confers a risk for MDS/AML, data on family members of SDS patients on the Canadian Inherited Marrow Failure Registry (CIMFR) was analyzed.ResultsOf two SDS patients with SDS/AML one was homozygous 258 + 2T > C, and one was compound heterozygous 183‐184TA > CT/258 + 2T > C. To determine whether a subset of patients with SDS can present with AML, we analyzed 48 AML samples at remission, but no mutations were identified. To address whether acquired mutated SBDS gene is associated with leukemic transformation in de novo AML, we analyzed 77 AML samples at diagnosis or relapse (4 with ‐7 and 7q‐) for SBDS mutations; no alterations were detected. Also, among the relatives of an SDS patient cohort on the registry no cases of MDS/AML were reported.ConclusionsCommon mutations occurred in our SDS patients who develop AML, and thus, AML is not confined to a rare genetic subgroup of SDS. Newly diagnosed patients with AML are unlikely to have an underlying undiagnosed SDS. Acquired SBDS gene mutations also would appear unlikely to play a mechanistic role in de novo AML, and might not be involved in the pathogenesis of chromosome 7 abnormalities as well. © 2005 Wiley‐Liss, Inc.
Helicobacter pylori as cause of gastrointestinal disease in children with hemato‐oncologic diseases
Authors: Castagnola Elio , Calvillo Michaela , Gigliotti Anna Rita , Fioredda Francesca , Hanau Guia , Caviglia Ilaria , Lanino Edoardo , Dufour Carlo 
Published: July 2005

AbstractAfter documentation of a case of life threatening Helicobacter pylori (H. pylori) gastric ulcer in an adolescent girl on treatment for acute lymphoblastic leukaemia, we started to systematically look for gastro‐intestinal symptoms due to H. pylori infection in our cancer patients at G. Gaslini Children's Hospital. During a period of 46 months, we observed 13 further cases of severe dyspepsia syndrome or gastro intestinal bleeding associated with presence of H. pylori faecal antigen. All patients recovered with appropriate therapy. H. pylori may represent a cause of severe gastrointestinal complications in children with cancer or following bone marrow transplant. © 2005 Wiley‐Liss, Inc.
A polymerizable photosensitizer and its photopolymerization kinetics
Authors: Wang Junzuo , Mathias Lon J 
Published: July 2005

AbstractA previously reported polymerizable benzophenone photosensitizer, 2‐methacryloxyethyl 4‐benzoylbenzoate (MEBB), was synthesized and characterized. The photopolymerization kinetics of methyl α‐hydroxymethylacrylate (MHMA) and 1,6‐hexanediol diacrylate (HDDA) initiated with MEBB or benzophenone (BP) in the presence or absence of amine co‐initiators were determined by photo‐differential scanning calorimetry. The results indicate that benzophenone with a p‐carbonyl substitutent is more efficient in photoinitiation when compared to the non‐substituted benzophenone analogue. The final monomer conversions in the presence of amine co‐initiators are slightly higher than without them. Copyright © 2005 Society of Chemical Industry
A comparison of different biotinylation reagents, tryptic digestion procedures, and mass spectrometric techniques for 2‐D peptide mapping of membrane proteins
Authors: Scheurer Simone B. , Roesli Christoph , Neri Dario , Elia Giuliano 
Published: July 2005

Abstract2‐D peptide mapping is a novel technique for the relative quantification of membrane proteins (Scheurer S. et al., Proteomics 2005, in press). Using closely related metastatic and nonmetastatic teratocarcinoma cell lines as a model system, we have performed a comparative analysis of different biotinylation reagents, tryptic digestion procedures, and mass spectrometric techniques, with the aim to increase the number of proteins identified by 2‐D peptide mapping. Our experience indicates that the LC‐MALDI TOF/TOF technique is superior to LC‐ESI MS/MS in terms of the number of proteins identified and confidence in protein identification. Furthermore, the best results were obtained by tryptic digestion of proteins eluted from a streptavidin column using a cleavable biotin derivative.
Dominance variation across six herbicides of the Arabidopsis thaliana csr1‐1 and csr1‐2 resistance alleles
Authors: Roux Fabrice , Matéjicek Annick , Gasquez Jacques , Reboud Xavier 
Published: July 2005

AbstractDominance of a resistance trait can be defined as a measure of the relative position of the phenotype of the heterozygote RS compared with the phenotype of the two corresponding homozygotes, SS and RR. This parameter has been shown to have primary importance in the dynamics of pesticide resistance evolution. Literature on insecticide resistance suggests that dominance levels in the presence of insecticide vary greatly from completely recessive to completely dominant. With insecticides, both the chemical applied and the dosages used have been demonstrated to affect the dominance. By contrast, almost all herbicide resistances have been found to be inherited as partially to totally dominant traits. This discrepancy between weeds and insects may partly result from the methodologies applied to measure the dominance, ie a single dose for herbicide versus several doses for insecticide. Using two well‐known resistances (csr1‐1 and csr1‐2) to acetolactate synthase (ALS) inhibitors in Arabidopsis thaliana (L) Heynh (mouse‐ear cress), we used several herbicide doses to determine the dominance level to six ALS‐inhibiting herbicides. The dominance level in the presence of herbicide varied from completely dominant to completely recessive, depending on the resistance allele and the herbicide tested. The dominance of the csr1‐1 and csr1‐2 resistance alleles ranged from 0 (completely recessive) to 1.1 (dominant) and from 0 to 0.3 (partially dominant), respectively. The recessivity of some resistance alleles in the presence of herbicide could lead to the development of improved resistance management in order to delay or avoid herbicide resistance evolution, especially in the control of outcrossing weed species. Copyright © 2005 Society of Chemical Industry
Interlayer coupling induced by domain structure in NiFe/Au/Co/Au multilayers
Authors: Urbaniak M. , Stobiecki F. , Szymański B. 
Published: July 2005

AbstractMagnetic and magnetotransport properties of (Ni80Fe20/Au/Co/Au)N multilayers with tCo = 0.6 nm and different thicknesses of Au layers (1.5 ≤ tAu ≤ 2.2 nm) have been investigated. The Co layer thickness used ensures its perpendicular anisotropy. We argue that in a hysteretic region of R(H) and M(H) dependencies the reorientation of Py layers is strongly influenced by the magnetic stray fields originating from the domain structure of Co layers. The values of stray fields are determined from R(H) and M(H) measurements and are compared with the calculated ones. (© 2005 WILEY‐VCH Verlag GmbH & Co. KGaA, Weinheim)
Investigations of atomic structure and bonding at domain boundaries in bulk La0.5Eu0.2Sr0.3MnO3
Authors: Sun B. Z. , He L. L. , Luo F. , Yan C. H. 
Published: July 2005

AbstractPerovskite ceramic samples of bulk La0.7Sr0.3MnO3 doped with Eu are prepared by usual thermal decomposition and grinding procedure. Besides La0.7Sr0.3MnO3 rhombohedral phase, with the substitution of Eu3+ for La3+, another perovskite‐based structure with orthorhombic symmetry and space group Pnma can be identified by means of electron diffraction patterns (EDP) and energy‐dispersive X‐ray spectroscopy (EDX). Many 120° large‐angle orientation domains with a three‐fold rotational symmetry relationship are observed in the orthorhombic grain. According to group theory of phase transformation and matrix analyses, the 120° orientation domain originates from the three‐fold symmetry axis of pseudo‐cubic parent phase. Meanwhile, a projected model of the domain boundary is constructed based on their orientation relationships. The distortions and arrangements of MnO6 octahedra on the domain boundary are discussed particularly. (© 2005 WILEY‐VCH Verlag GmbH & Co. KGaA, Weinheim)
Formation of erbium–oxygen nanoclusters in erbium‐doped oxidized amorphous silicon
Authors: Bresler Mikhail , Gusev Oleg , Terukov Evgenii , Undalov Yurii 
Published: July 2005

AbstractA “phase transition” model is presented, which treats quantitatively the experimental results obtained on erbium‐doped oxidized amorphous silicon. The model is based on the assumption that on the change of molar concentration of oxygen in the gaseous plasma during the preparation of erbium‐doped amorphous silicon at special oxygen concentrations supramolecular erbium–oxygen complexes (“clusters') are formed in the plasma, which are eventually deposited as separate species on the substrate. The threshold formation of such clusters is evidenced in the concentration of oxygen, oxygen–silicon bonds, silicon, and erbium in the erbium‐doped oxidized amorphous silicon film. Erbium photoluminescence is strongly enhanced due to the formation of large erbium–oxygen clusters, which can be regarded as erbium containing nanodielectric particles inserted in the semiconductor matrix and reveal advantages characteristic of erbium‐doped silicon dioxide with silicon nanocrystals. (© 2005 WILEY‐VCH Verlag GmbH & Co. KGaA, Weinheim)
Quantum fluid effects and parametric instabilities in microcavities
Authors: Ciuti Cristiano , Carusotto Iacopo 
Published: July 2005

AbstractWe present a description of the non‐equilibrium properties of a microcavity polariton fluid, injected by a nearly‐resonant continuous wave pump laser. In the first part, we point out the interplay between the peculiar dispersion of the Bogoliubov‐like polariton excitations and the onset of polariton parametric instabilities. We show how collective excitation spectra having no counterpart in equilibrium systems can be observed by tuning the excitation angle and frequency. In the second part, we explain the impact of these collective excitations on the in‐plane propagation of the polariton fluid. We show that the resonant Rayleigh scattering induced by artificial or natural defects is a very sensitive tool to reveal novel fascinating effects such as polariton superfluidity or to show new aspects of the Cherenkov effect. We present a comprehensive set of predicted far‐field and near‐field images for the resonant Rayleigh scattering emission. (© 2005 WILEY‐VCH Verlag GmbH & Co. KGaA, Weinheim)
Bose–Einstein condensation of microcavity polaritons
Authors: Savona Vincenzo , Sarchi Davide 
Published: July 2005

AbstractAfter resuming the basic facts about Bose–Einstein condensation of weakly interacting systems, we review the main experimental and theoretical works aimed at the realization of this intriguing phenomenon in the system of microcavity polaritons. All the experimental results until present suggest that Bose–Einstein condensation is still eluding the experimentalists' efforts. On the theoretical side, only recently polaritons have been described within a quantum field theory of an interacting Bose gas, suggesting that polariton condensation might occur at least as a consequence of polariton parametric scattering under resonant excitation. (© 2005 WILEY‐VCH Verlag GmbH & Co. KGaA, Weinheim)
Chirality Factors and Their Application to QSAR Studies of Chiral Molecules
Authors: Yang Chunsheng , Zhong Chongli 
Published: July 2005

AbstractTwo series of chirality factors that can distinguish enantiomers and diastereomers were developed in this work and the corresponding chiral topological indices were proposed. The obtained chiral topological indices can be used to perform QSAR studies for chiral molecules. The biological activities of fourteen 3‐(3‐hydroxyphenyl)‐ piperidines (seven pairs of enantiomers), the high‐pressure thin‐layer chromatographic retention indices of eight hydroxy acids and ten amino acids (nine pairs of enantiomers), the ED50 of 23 ecdysteroids (19 pairs of diastereomers), and the corticosteroid‐binding globulins affinities of 31 steroids were used to evaluate the chirality factors and the corresponding chiral topological indices. The QSAR models developed give satisfactory predictive accuracy. Compared with the existing methods, the chirality factor method proposed in this work has the advantage of being applicable to the existing topological indices directly. This makes good use of the existing topological indices, and thus brings convenience to the QSAR studies for chiral molecules. Another advantage of the new method is that it can also correctly describe the characteristics of meso compounds.
Use of Topological Indices of Organic Sulfur Compounds in Quantitative Structure‐Retention Relationship Study
Authors: Safa F. , Hadjmohammadi M. R. 
Published: July 2005

AbstractStructure‐gas chromatographic retention index models were developed for some organic sulfur compounds at four different temperatures (60, 80, 100 and 120 °C) using only topological descriptors. At first, regression models were generated for each temperature separately with high values of multiple correlation coefficient and Fisher‐ratio statistics. The results of cross validation test using leave‐one‐out (Q2≥0.956) and leave‐two‐out (Q2≥0.953) methods showed good predictive ability of the models developed. Then, a single combined quantitative structure‐retention relationship model, added temperature as a parameter, was also developed for all the temperatures, showing good statistical parameters (R=0.991 and F=728.474). The stability and validity of the combined model were verified by both internal (Q2>0.970) and external validation (Q$\rm{ {_{prediction\;set}^{2}}}$=0.993) techniques. The results of the study indicated the efficiency of the classical topological descriptors in simultaneous prediction of retention index values of sulfur compounds at different temperatures. The topological descriptors well covered the molecular properties known to be relevant for gas chromatographic retention data, such as molecular size and degree of branching.