bluuebunny/crossref_metadata_2025_split huggingface dataset:
An analytical late–Universe approach to the weaving of modern cosmology
Authors: Cogato Fabrizio , Moresco Michele , Amati Lorenzo , Cimatti Andrea 
Published: November 2023

ABSTRACT
Combining cosmological probes has consolidated the standard cosmological model with per cent precision, but some tensions have recently emerged when certain parameters are estimated from the local or primordial Universe. The origin of this behaviour is still under debate; however, it is crucial to study as many probes as possible to cross-check the results with independent methods and provide additional pieces of information to the cosmological puzzle. In this work, by combining several late-Universe probes (0 &lt; z &lt; 10), namely, Type Ia supernovae, baryon acoustic oscillations, cosmic chronometers, and gamma-ray bursts, we aim to derive cosmological constraints independently of local or early-Universe anchors. To test the standard cosmological model and its various extensions, considering an evolving dark energy equation of state and the curvature as a free parameter, we analyse each probe individually and all their possible permutations. Assuming a flat Lambda cold dark matter (ΛCDM) model, the full combination of probes provides $H_0=67.2^{+3.4}_{-3.2}$ km s−1 Mpc−1 and Ωm = 0.325 ± 0.015 [68 per cent confidence level (C.L.)]. Considering a flat wCDM model, we measure $w_0=-0.91^{+0.07}_{-0.08}$ (68 per cent C.L.), while by relaxing the flatness assumption (ΛCDM model, 95 per cent C.L.) we obtain $\Omega _k=0.125^{+0.167}_{-0.165}$. Finally, we analytically characterize the degeneracy directions and the relative orientation of the probes’ contours. By calculating the figure-of-merit, we quantify the synergies among independent methods, estimate the constraining power of each probe, and identify which provides the best contribution to the inference process. Pending the new cosmological surveys, this study confirms the exigency for new emerging probes in the landscape of modern cosmology.
A targeted search for FRB counterparts with Konus-Wind
Authors: Ridnaia A , Frederiks D , Svinkin D 
Published: November 2023

ABSTRACT
We present results of the search for hard X-ray/soft gamma-ray emission in coincidence with publicly reported (via Transient Name Server, TNS1) fast radio bursts (FRBs). The search was carried out using continuous Konus-Wind data with 2.944 s time resolution. We perform a targeted search for each individual burst from 581 FRBs, along with a stacking analysis of the bursts from eight repeating sources in our sample and a separate stacking analysis of the bursts from the non-repeating FRBs. We find no significant associations in either case. We report upper bounds on the hard X-ray (20–1500 keV) flux assuming four spectral models, which generally describe spectra of short and long gamma-ray bursts (GRBs), magnetar giant flares, and the short burst, coincident with FRB 200428 from a Galactic magnetar. Depending on the spectral model, our upper bounds are in the range of (0.1–2) × 10−6 erg cm−2. For 18 FRBs with known distances, we present upper bounds on the isotropic equivalent energy release and peak luminosity. For the nearest FRB 200120E, we derive the most stringent upper bounds of Eiso ≤ 2.0 × 1044 erg and Liso ≤ 1.2 × 1044 erg s−1. Furthermore, we report lower bounds on radio-to-gamma-ray fluence ratio Eradio/Eiso ≥ 10−11–10−9 and compare our results with previously reported searches and theoretical predictions for high-energy counterparts to FRBs.
Seven white dwarfs with circumstellar gas discs I: white dwarf parameters and accreted planetary abundances
Authors: Rogers L K , Bonsor A , Xu S , Dufour P , Klein B L , Buchan A , Hodgkin S , Hardy F , Kissler-Patig M , Melis C , Weinberger A J , Zuckerman B 
Published: November 2023

ABSTRACT
Observations of planetary material polluting the atmospheres of white dwarfs are an important probe of the bulk composition of exoplanetary material. Medium- and high-resolution optical and ultraviolet spectroscopy of seven white dwarfs with known circumstellar dust and gas emission are presented. Detections or meaningful upper limits for photospheric absorption lines are measured for: C, O, Na, S, P, Mg, Al, Si, Ca, Ti, Cr, Fe, and Ni. For 16 white dwarfs with known observable gaseous emission discs (and measured photospheric abundances), there is no evidence that their accretion rates differ, on average, from those without detectable gaseous emission. This suggests that, typically, accretion is not enhanced by gas drag. At the effective temperature range of the white dwarfs in this sample (16 000–25 000 K) the abundance ratios of elements are more consistent than absolute abundances when comparing abundances derived from spectroscopic white dwarf parameters versus photometric white dwarf parameters. Crucially, this highlights that the uncertainties on white dwarf parameters do not prevent white dwarfs from being utilized to study planetary composition. The abundances of oxygen and silicon for the three hydrogen-dominated white dwarfs in the sample with both optical and ultraviolet spectra differ by 0.62 dex depending on if they are derived from the optical or ultraviolet spectra. This optical/ultraviolet discrepancy may be related to differences in the atmospheric depth of line formation; further investigations into the white dwarf atmospheric modelling are needed to understand this discrepancy.
Constraining the long-lived supramassive neutron stars by magnetar boosted kilonovae
Authors: Wang Hao , Beniamini Paz , Giannios Dimitrios 
Published: November 2023

ABSTRACT
Kilonovae are optical transients following the merger of neutron star binaries, which are powered by the r-process heating of merger ejecta. However, if a merger remnant is a long-lived supramassive neutron star supported by its uniform rotation, it will inject energy into the ejecta through spin-down power. The energy injection can boost the peak luminosity of a kilonova by many orders of magnitudes, thus significantly increasing the detectable volume. Therefore, even if such events are only a small fraction of the kilonova population, they could dominate the detection rates. However, after many years of optical sky surveys, no such event has been confirmed. In this work, we build a boosted kilonova model with rich physical details, including the description of the evolution and stability of a proto neutron star, and the energy absorption through X-ray photoionization. We simulate the observation prospects and find the only way to match the absence of detection is to limit the energy injection by the newly born magnetar to only a small fraction of the neutron star rotational energy, thus they should collapse soon after the merger. Our result indicates that most supramassive neutron stars resulting from binary neutron star mergers are short lived and they are likely to be rare in the Universe.
Increasing planet-stirring efficiency of debris discs by ‘projectile stirring’ and ‘resonant stirring’
Authors: Costa Tyson , Pearce Tim D , Krivov Alexander V 
Published: November 2023

ABSTRACT
Extrasolar debris discs are detected by observing dust, which is thought to be released during planetesimal collisions. This implies that planetesimals are dynamically excited (‘stirred’), such that collisions are sufficiently common and violent. The most frequently considered stirring mechanisms are self-stirring by disc self-gravity, and planet-stirring via secular interactions. However, these models face problems when considering disc mass, self-gravity, and planet eccentricity, leading to the possibility that other, unexplored mechanisms instead stir debris. We hypothesize that planet-stirring could be more efficient than the traditional secular model implies, due to two additional mechanisms. First, a planet at the inner edge of a debris disc can scatter massive bodies on to eccentric, disc-crossing orbits, which then excite debris (‘projectile stirring’). Second, a planet can stir debris over a wide region via broad mean-motion resonances, both at and between nominal resonance locations (‘resonant stirring’). Both mechanisms can be effective even for low-eccentricity planets, unlike secular-planet-stirring. We run N-body simulations across a broad parameter space, to determine the viability of these new stirring mechanisms. We quantify stirring levels using a bespoke program for assessing rebound debris simulations, which we make publicly available. We find that even low-mass projectiles can stir discs, and verify this with a simple analytic criterion. We also show that resonant stirring is effective for planets above ${\sim 0.5\, {\rm M_{Jup}}}$. By proving that these mechanisms can increase planet-stirring efficiency, we demonstrate that planets could still be stirring debris discs even in cases where conventional (secular) planet-stirring is insufficient.
Phosphate Limitation Responses in Marine Green Algae Are Linked to Reprogramming of the tRNA Epitranscriptome and Codon Usage Bias
Authors: Hehenberger Elisabeth , Guo Jian , Wilken Susanne , Hoadley Kenneth , Sudek Lisa , Poirier Camille , Dannebaum Richard , Susko Edward , Worden Alexandra Z 
Published: November 2023

Abstract
Marine algae are central to global carbon fixation, and their productivity is dictated largely by resource availability. Reduced nutrient availability is predicted for vast oceanic regions as an outcome of climate change; however, there is much to learn regarding response mechanisms of the tiny picoplankton that thrive in these environments, especially eukaryotic phytoplankton. Here, we investigate responses of the picoeukaryote Micromonas commoda, a green alga found throughout subtropical and tropical oceans. Under shifting phosphate availability scenarios, transcriptomic analyses revealed altered expression of transfer RNA modification enzymes and biased codon usage of transcripts more abundant during phosphate-limiting versus phosphate-replete conditions, consistent with the role of transfer RNA modifications in regulating codon recognition. To associate the observed shift in the expression of the transfer RNA modification enzyme complement with the transfer RNAs encoded by M. commoda, we also determined the transfer RNA repertoire of this alga revealing potential targets of the modification enzymes. Codon usage bias was particularly pronounced in transcripts encoding proteins with direct roles in managing phosphate limitation and photosystem-associated proteins that have ill-characterized putative functions in “light stress.” The observed codon usage bias corresponds to a proposed stress response mechanism in which the interplay between stress-induced changes in transfer RNA modifications and skewed codon usage in certain essential response genes drives preferential translation of the encoded proteins. Collectively, we expose a potential underlying mechanism for achieving growth under enhanced nutrient limitation that extends beyond the catalog of up- or downregulated protein-encoding genes to the cell biological controls that underpin acclimation to changing environmental conditions.
Kidney phosphate wasting predicts poor outcome in polycystic kidney disease
Authors: Xue Laixi , Geurts Frank , Meijer Esther , de Borst Martin H , Gansevoort Ron T , Zietse Robert , Hoorn Ewout J , Salih Mahdi ,   the DIPAK Consortium, Drenth Joost P H , de Fijter Johannes W , Losekoot Monique , Peters Dorien J M , Wetzels Jack F , Nijenhuis Tom 
Published: November 2023

ABSTRACT

Background
Patients with autosomal dominant polycystic kidney disease (ADPKD) have disproportionately high levels of fibroblast growth factor 23 (FGF-23) for their chronic kidney disease stage, however only a subgroup develops kidney phosphate wasting. We assessed factors associated with phosphate wasting and hypothesize that it identifies patients with more severe disease and predicts disease progression.

Methods
We included 604 patients with ADPKD from a multicenter prospective observational cohort (DIPAK; Developing Intervention Strategies to Halt Progression of Autosomal Dominant Polycystic Kidney Disease) in four university medical centers in the Netherlands. We measured parathyroid hormone (PTH) and total plasma FGF-23 levels, and calculated the ratio of tubular maximum reabsorption rate of phosphate to glomerular filtration rate (TmP/GFR) with &lt;0.8 mmol/L defined as kidney phosphate wasting. We analysed the association of TmP/GFR with estimated GFR (eGFR) decline over time and the risk for a composite kidney outcome (≥30% eGFR decline, kidney failure or kidney replacement therapy).

Results
In our cohort (age 48 ± 12 years, 39% male, eGFR 63 ± 28 mL/min/1.73 m2), 59% of patients had phosphate wasting. Male sex [coefficient –0.2, 95% confidence interval (CI) –0.2; –0.1], eGFR (0.002, 95% CI 0.001; 0.004), FGF-23 (0.1, 95% CI 0.03; 0.2), PTH (–0.2, 95% CI –0.3; –0.06) and copeptin (–0.08, 95% CI –0.1; –0.08) were associated with TmP/GFR. Corrected for PTH, FGF-23 and eGFR, every 0.1 mmol/L decrease in TmP/GFR was associated with a greater eGFR decline of 0.2 mL/min/1.73 m2/year (95% CI 0.01; 0.3) and an increased hazard ratio of 1.09 (95% CI 1.01; 1.18) of the composite kidney outcome.

Conclusion
Our study shows that in patients with ADPKD, phosphate wasting is prevalent and associated with more rapid disease progression. Phosphate wasting may be a consequence of early proximal tubular dysfunction and insufficient suppression of PTH.
Mating system is associated with seed phenotypes upon loss of RNA-directed DNA methylation in Brassicaceae
Authors: Dew-Budd Kelly J , Chow Hiu Tung , Kendall Timmy , David Brandon C , Rozelle James A , Mosher Rebecca A , Beilstein Mark A 
Published: November 2023

Abstract
In plants, de novo DNA methylation is guided by 24-nt short interfering (si)RNAs in a process called RNA-directed DNA methylation (RdDM). Primarily targeted at transposons, RdDM causes transcriptional silencing and can indirectly influence expression of neighboring genes. During reproduction, a small number of siRNA loci are dramatically upregulated in the maternally derived seed coat, suggesting that RdDM might have a special function during reproduction. However, the developmental consequence of RdDM has been difficult to dissect because disruption of RdDM does not result in overt phenotypes in Arabidopsis (Arabidopsis thaliana), where the pathway has been most thoroughly studied. In contrast, Brassica rapa mutants lacking RdDM have a severe seed production defect, which is determined by the maternal sporophytic genotype. To explore the factors that underlie the different phenotypes of these species, we produced RdDM mutations in 3 additional members of the Brassicaceae family: Camelina sativa, Capsella rubella, and Capsella grandiflora. Among these 3 species, only mutations in the obligate outcrosser, C. grandiflora, displayed a seed production defect similar to Brassica rapa mutants, suggesting that mating system is a key determinant for reproductive phenotypes in RdDM mutants.
Racial, socioeconomic, and neighborhood characteristics in relation to COVID-19 severity of illness for adolescents and young adults
Authors: Dahleh Ayaat , Bean Andrew J , Johnson Tricia J 
Published: November 2023

Abstract
This study tests the hypotheses that insurance status, race and ethnicity, and neighborhood characteristics are associated with hospital admission and severe health outcomes (Intensive Care Unit [ICU] admission and oxygen assistance) for youth and young adults who present to the emergency department (ED) with COVID-19 in a single, academic health system in Illinois, Rush University System for Health (RUSH). Demographic and clinical data from the electronic health record were collected for all 13- to 24-y-old patients seen at RUSH who tested positive for COVID-19 between March 2020 and 2021. Individual-level and neighborhood characteristics were analyzed to determine their association with hospital admission and severe health outcomes through generalized estimating equations. As of March 2021, 1,057 patients were seen in the ED within RUSH in which non-Hispanic White (odds ratio [OR], 2.96; 95% CI, 1.61–5.46; P = 0.001) and Hispanic (OR, 3.34; 95% CI, 1.84–6.10; P &lt; 0.001) adolescents and youth were more likely to be admitted to the hospital compared with non-Hispanic Black/other adolescents and youth. Patients with public insurance or who were uninsured were less likely to be admitted to the ICU compared with those with private insurance (OR, 0.24; 95% CI, 0.09–0.64; P = 0.004). None of the neighborhood characteristics were significantly associated with hospital admission or severe health outcomes after adjusting for covariates. Our findings demonstrated that race and ethnicity were related to hospitalization, while insurance was associated with presentation severity due to COVID-19 for adolescents and young adults. These findings can aid public health investigators in understanding COVID-19 disparities among adolescents and young adults.
Taking pluralism seriously: a new perspective on evidence-based policy
Authors: Bschir Karim , Lohse Simon 
Published: November 2023

Abstract
Scientific policy advice in the face of complex real-world problems requires a maximally pluralistic knowledge base. However, integrating different types of knowledge from a variety of sources raises a series of highly challenging epistemic as well as practical problems. We propose an integrated model of pluralistic policy advice emphasizing the appropriate constitution and structure of pluralistic expert panels. Furthermore, we suggest that normative assumptions underlying expert advice should be made explicit to policymakers. The goal should not be to avoid normative biases, but rather to create transparency with respect to the unavoidable value judgements that influence the epistemic preferences of experts and to provide policymakers with evidence-based scenarios that range over a variety of value preferences.
Lactate produced by alveolar type II cells suppresses inflammatory alveolar macrophages in acute lung injury
Authors: Roy René M. , Allawzi Ayed , Burns Nana , Sul Christina , Rubio Victoria , Graham Jessica , Stenmark Kurt , Nozik Eva S. , Tuder Rubin M. , Vohwinkel Christine U. 
Published: November 2023

AbstractAlveolar inflammation is a hallmark of acute lung injury (ALI), and its clinical correlate is acute respiratory distress syndrome—and it is as a result of interactions between alveolar type II cells (ATII) and alveolar macrophages (AM). In the setting of acute injury, the microenvironment of the intra‐alveolar space is determined in part by metabolites and cytokines and is known to shape the AM phenotype. In response to ALI, increased glycolysis is observed in AT II cells, mediated by the transcription factor hypoxia‐inducible factor (HIF) 1α, which has been shown to decrease inflammation. We hypothesized that in acute lung injury, lactate, the end product of glycolysis, produced by ATII cells shifts AMs toward an anti‐inflammatory phenotype, thus mitigating ALI. We found that local intratracheal delivery of lactate improved ALI in two different mouse models. Lactate shifted cytokine expression of murine AMs toward increased IL‐10, while decreasing IL‐1 and IL‐6 expression. Mice with ATII‐specific deletion of Hif1a and mice treated with an inhibitor of lactate dehydrogenase displayed exacerbated ALI and increased inflammation with decreased levels of lactate in the bronchoalveolar lavage fluid; however, all those parameters improved with intratracheal lactate. When exposed to LPS (to recapitulate an inflammatory stimulus as it occurs in ALI), human primary AMs co‐cultured with alveolar epithelial cells had reduced inflammatory responses. Taken together, these studies reveal an innate protective pathway, in which lactate produced by ATII cells shifts AMs toward an anti‐inflammatory phenotype and dampens excessive inflammation in ALI.
How acculturation contributes to a rise of diabetes in Hmong Americans
Authors: Xiong Tou 
Published: November 2023

ABSTRACT
This article explores the reasons for the high prevalence of diabetes among Hmong Americans, who are at greater risk for diabetes compared with non-Hispanic White patients and have a higher prevalence of diabetes than other Asian Americans and other races. Knowledge of this issue may allow medical practitioners to identify, screen, and treat Hmong Americans more frequently and at earlier ages. Although better integration of healthcare services, access, and education are needed, earlier screening may help start the diabetes education process sooner; reduce hospital, ED, and office visits; reduce costs; and prevent end-organ damage.
Implementing an Adult Extracorporeal Membrane Oxygenation Program During the COVID-19 Pandemic
Authors: Pitts Brandy , Vaughan Midge , Roney Jamie Kay 
Published: November 2023

ABSTRACT

Background:
In response to the needs of patients infected with COVID-19, an interdisciplinary team was assembled to implement an adult extracorporeal membrane oxygenation (ECMO) program in the surgical ICU of a West Texas tertiary care hospital. Use of Extracorporeal Life Support Organization (ELSO) guidelines was essential to the development of this effort.

Aim:
The aim of this project was to develop, implement, and evaluate an adult ECMO program.

Methods:
A logic model was used in designing and evaluating the adult ECMO program. A 35-hour ECMO specialist training course was developed, and training began in August 2020, a month before implementation of the project began. Patient outcomes were measured between September 2020 and December 2021. Descriptive statistics were used to measure the clinical outcomes of interest.

Results:
Seventeen newly trained ECMO specialists included experienced critical care nurses and respiratory therapists. Protocols were developed for the initiation of ECMO, and tracked patient outcomes included survival off ECMO, survival to discharge, major and minor complications, and length of stay. Nine patients had COVID-19 and demonstrated an 11.11% mortality rate after adult ECMO program implementation.

Conclusions:
Use of the ELSO professional guidelines to design and develop this project led to the achievement of a sustainable ECMO program. Hospital leaders can now implement adult ECMO programs amid other demands for resources that may be created by future pandemics.
Binge-eating disorder
Authors: Scrandis Debra A. , Arnow Deborah 
Published: November 2023

Abstract:
Binge-eating disorder (BED) has the highest prevalence of any eating disorder in the US today. However, the condition is frequently not recognized as an eating disorder by healthcare providers or patients. Patients with this diagnosis often have significant psychiatric and medical comorbidities that might respond to evidence-based treatments. NPs in primary care with awareness of the diagnostic criteria for BED and knowledge of its assessment and treatment options can coordinate care for patients experiencing this health challenge.
Vaccination updates and special considerations for systemic lupus erythematosus patients
Authors: Law Jammie , Sorrento Cristina , Saxena Amit 
Published: November 2023

Purpose of review
We review the latest guidelines and note special considerations for systemic lupus erythematosus (SLE) patients when approaching vaccination against SARS-CoV-2, influenza, pneumococcus, herpes zoster, and potentially respiratory syncytial virus (RSV) vaccine in the future.

Recent findings
SLE patients have unique infectious risks due to newer treatments and the nature of the disease itself. It is important to balance the benefit of additional protective immunity from updated vaccines against the possible risk of disease activity exacerbations.

Summary
It is important to continuously evaluate the safety and immunogenicity of updated vaccines specifically for SLE patients. Additionally, the newly approved RSV vaccine should be considered for this population to reduce severe respiratory illness.