bluuebunny/crossref_metadata_2025_split huggingface dataset:
Experimental Study of 3D-TableTrix Microcarriers Loaded with Low-dose Bone Marrow Mesenchymal Stem Cells for the Treatment of Early Osteonecrosis of the Femoral Head
Authors: Guo Minzheng , Qi Baochuang , Pei Zijie , Ni Haonan , Ren Junxiao , Luo Huan , Shi Hongxin , Meng Chen , Rao Yu , Tang Zhifang , Pu Luqiao , Xue Qingyun , Xu Yongqing , Li Chuan 
Published: November 2023

Abstract
Background
Early treatment of ONFH (osteonecrosis of the femoral head) has posed a significant challenge for clinicians. Recent attention has been directed towards stem cell therapy, with BMSCs (bone marrow mesenchymal stem cells) emerging as a potential solution for early-stage ONFH due to their unique capabilities. However, traditional cell injection methods have been associated with unsatisfactory results attributed to issues such as mechanical damage during injection, low cell survival rates, limited cell matrix accumulation, and absence of cellular interactions. To address these concerns, this study utilized a novel cell carrier material called 3D-TableTrix Microcarriers capable of loading BMSCs.
Methods
Through imaging, serological, and histological analyses, low-dose BMSC-loaded Microcarriers were intravenously injected into a rat model of early-stage hormone-induced osteonecrosis of the femoral head. Repair outcomes were compared to those obtained from high-dose BMSC injections to evaluate the efficacy and safety of this improved strategy. Additionally, a co-culture system study was conducted, in which human primary osteoblasts were seeded in the lower layer, while 3D-TableTrix Microcarrier-loaded human BMSCs or monolayer-cultured human BMSCs were seeded in the upper layer. Phenotypic analysis of the co-cultured human osteoblasts focused on comparing the effects of different BMSC cultivation methods.
Results
The Microcarriers containing low-dose BMSCs demonstrated comparable repair outcomes to high-dose BMSC injections in the rat model of early-stage hormone-induced osteonecrosis of the femoral head, while minimizing the associated risks of high-dose stem cell administration. Furthermore, the co-culture system revealed that the osteoblasts in the 3D group exhibited a superior phenotype compared to the monolayer-cultured group. Gene ontology and Kyoto Encyclopedia of Genes and Genomes (KEGG) pathway analysis provided insights into the mechanisms underlying the therapeutic effects of 3D Microcarriers loaded with BMSCs in early-stage hormone-induced osteonecrosis of the femoral head.
Conclusions
This study confirms that 3D-TableTrix Microcarriers loaded with BMSCs offer a promising cellular therapy for early-stage hormone-induced osteonecrosis of the femoral head, potentially achieving efficient treatment outcomes with minimal cell dosages. The improved strategy addresses challenges associated with traditional cell injection methods and highlights the potential of BMSC-loaded Microcarriers to improve the management of early-stage ONFH.
Drivers of regional Australian marine heatwaves on sub-seasonal to seasonal timescales
Authors: Gregory Catherine Hannah , Holbrook Neil J. , Marshall Andrew G , Spillman Claire M 
Published: November 2023

AbstractAs marine heatwaves (MHWs) become more intense and longer lasting due to global warming, understanding the drivers and impacts of these events is crucial for effective marine resource management. This study investigates the influence of El Niño Southern Oscillation (ENSO), the Indian Ocean Dipole (IOD), Southern Annular Mode (SAM), Sub-Tropical Ridge High (STRH), and Madden Julian Oscillation (MJO) on sea surface temperature (SST) anomalies and MHWs around Australia. The aim of this research is to improve our understanding of the drivers of MHWs on sub-seasonal to seasonal (S2S) timescales, which bridges the gap between short-term weather and interannual to long-term climate variability. By analysing SST anomalies and MHWs characteristics during specific driver phases, a simple MHW hazard index is developed. Our findings support previous research indicating that La Niña plays a role in driving MHWs off the coast of Western Australia and reveals a previously unrecognised connection between ocean warming off Queensland and Tasman Sea low-pressure systems associated with the negative phase of the STRH. Our research emphasizes the importance of considering multiple drivers and their compounding effects on MHWs by showing significant changes to typical La Niña MHW patterns with the additional influence of the MJO. By considering drivers acting in the S2S timescale, forecasts can more accurately capture the timing, intensity, and spatial extent of MHW events within a season. These improved forecasts can enhance the ability of marine managers to adapt and allocate resources based on evolving climate conditions, enabling effective implementation of harm minimisation strategies.
An unusual diarrheal outbreak in the community in Eastern Thailand caused by Norovirus GII.3[P25]
Authors: Udompat Patpong , Srimu Krongkan , Doung-Ngern Pawinee , Thippamom Nattakarn , Petcharat Sininat , Rattanatumhi Khwankamon , Khiewbanyang Sirorat , Taweewigyakarn Pantila , Kripattanapong Somkid , Ninwattana Sasiprapa , Supataragul Ananporn , Sterling Spencer L. , Klungthong Chonticha , Joonlasak Khajohn , Manasatienkij Wudtichai , Cotrone Thomas S , Fernandez Stefan , Wacharapluesadee Supaporn , Putcharoen Opass 
Published: November 2023

Abstract
Background
Sentinel laboratory surveillance for diarrheal disease determined norovirus to be the most common cause of non-bacterial gastroenteritis in people during the COVID-19 pandemic in Thailand. An increase in patients presenting with diarrhea and vomiting in hospitals across Chanthaburi province between December 2021 and January 2022 led to the need for the identification of viral pathogens that may be responsible for the outbreak.
Methods
Feces samples (rectal swabs or stool) from 93 patients, of which 65 patients were collected during the December 2021 to January 2022 outbreak, were collected and screened for viral infection by real-time RT-PCR. Positive samples for norovirus GII were then genotyped by targeted amplification and sequencing of partial polymerase and capsid genes. Whole genome sequencing was performed from the predominant strain, GII.3[P25].
Results
Norovirus was the most common virus detected in human fecal samples in this study. 39 of 65 outbreak samples (60%) and 3 of 28 (10%) non-outbreak samples were positive for norovirus genogroup II. One was positive for rotavirus, and one indicated co-infection with rotavirus and norovirus genogroups I and II. Nucleotide sequences of VP1 and RdRp gene were successfully obtained from 28 of 39 positive norovirus GII and used for dual-typing; 25/28 (89.3%) were GII.3, and 24/28 (85.7) were GII.P25, respectively. Norovirus GII.3[P25] was the predominant strain responsible for this outbreak. The whole genome sequence of norovirus GII.3[P25] from our study is the first reported in Thailand and has 98.62% and 98.57% similarity to norovirus found in China in 2021 and USA in 2022, respectively. We further demonstrate the presence of multiple co-circulating norovirus genotypes, including GII.21[P21], GII.17[P17], and unassignable RdRp in GII.3 and GII.4 in our study.
Conclusions
An unusual diarrhea outbreak was found in December 2021 in eastern Thailand. Norovirus strain GII.3[P25] was the cause of the outbreak and was first detected in Thailand. The positive rate during GII.3[P25] outbreak was six times higher than sporadic cases (GII.4), and, atypically, adults were the primary infected population rather than children.
Spinal Muscle Characteristics During Three Different Types of Locomotion Activities among College Students with Idiopathic Scoliosis
Authors: WANG Xiangbin , GOU Yanyun , TAO Jing , HUANG Jia , HOU Meijin , SUN Yifan , CHEN Xiang 
Published: November 2023

Abstract

Background context:
Physical activities such as walking and climbing stairs are pervasive in human daily life. Individuals with scoliosis frequently encounter dysfunction in their muscle recruitment. Multiple studies have corroborated the presence of muscle dysfunction in individuals diagnosed with scoliosis. However, there is currently a noteworthy research gap regarding the exploration of changes in muscle characteristics and disparities from those observed in individuals without scoliosis during everyday activities, specifically stair climbing.
Purpose
This study aims to examine the unique patterns of muscle activity during daily life in individuals with scoliosis and distinguish the specific differences between scoliosis patients and the healthy controls. The findings of this study are significantly important for the future accurate assessment of scoliosis and the development of rehabilitation treatment plans.
Study design:
Case-control study
Sample size:
28 IS and 28 controls
Outcome measures:
Root Mean Square(RMS), Maximum Voluntary Isometric Contraction(MVIC)%, RMS ratio(RMS convex / RMS concave)
Methods
The surface electromyography (sEMG) device utilized in this study was the Delsys Trigno, which is manufactured in the USA. It has a sampling frequency of 1500Hz. It recorded the activation level, peak contraction, and average activation level of the erector spinae (at T6, T10, and L3 levels), gluteus maximus, gluteus medius, external oblique, and rectus abdominis muscles during three different types of locomotion for both the 28 individuals with IS and the 28 control participants.
Results
The movement patterns of the IS patient significantly differ from those of the normal population during level walking and ascending or descending stairs. In level walking, there is an asymmetry in the activation levels of the T6 and L3 erector spinae muscles, with lower activation on the convex side compared to the concave side. Similarly, during stair ascent, the activation of the T6 and T10 erector spinae muscles is asymmetric, with higher activation on the convex side than the concave side. Moreover, during stair descent, the activation of the T6 erector spinae muscle is asymmetric, with higher activation on the convex side than the concave side.
Conclusions
During level walking and stair activities, IS patients exhibit pronounced abnormal movement patterns that significantly differ from those of the control group. Under different activity conditions such as level walking, ascending and descending stairs, IS patients demonstrate abnormal muscle activation in different segments of the spine. It is crucial for clinicians to prioritize the symmetry of muscle activation in the spinal region of IS patients and consider incorporating symmetry training for these muscles.
Dynamical phase-field model of cavity electromagnonic systems
Authors: Hu Jia-Mian , Zhuang Shihao , Zhong Changchun , Jiang Liang , Zhang Xufeng 
Published: November 2023

Abstract

Cavity electromagnonic system, which simultaneously consists of cavities for microwave photons, magnons (quanta of spin waves), and acoustic phonons, provides an exciting platform to achieve coherent energy transduction among different physical systems down to single quantum level. Here we report a dynamical phase-field model that allows simulating the coupled dynamics of the electromagnetic waves, magnetization, and strain in 3D electromagnonic systems which have previously not been considered together. As examples of application, we computationally demonstrate the excitation of hybrid magnon-photon modes (magnon polaritons), Floquet-induced magnonic Aulter-Townes splitting, dynamical energy exchange (Rabi oscillation) and relative phase control (Ramsey interference) between the two magnon polariton modes. The simulation results are well consistent with analytical calculations based on Floquet Hamiltonian theory. With the capability to predict coupling strength, dissipation rates, and temporal evolution of photon/magnon/phonon mode profiles using only fundamental materials parameters as inputs, the present dynamical phase-field model represents a critically needed computational tool to guide and accelerate the fabrication of the cavity electromagnonic system and the design of operating conditions for applications in quantum sensing, transduction, and communication.
Aggregation of partial T-indistinguishability operators: An application for the image recognition
Authors: Güner Elif 
Published: November 2023

Abstract
In this paper, we first define the concept of residual domination which is more strong than the notion of domination. Then, we investigate how to combine a collection of partial indistinguishability operators into a single one by means of residual domination. Then, we give an application of the proposed aggregation technique to the detection of an image by the robots.
EGFR and MMP7 are important targets for gastric cancer metastasis
Authors: Ding Biran , Wan Yiqiu , Wu Yao , Zhang Zhan , Ma Ying , Wang Zuo , Jiang Runqiu 
Published: November 2023

Abstract
The invasion and metastasis of gastric cancer pose frequent clinical challenges following standard treatment. Investigating the molecular mechanisms underpinning gastric cancer invasion and metastasis constitutes a critical research area. This study aims to pinpoint potential target molecules involved in gastric cancer metastasis. After analyzing the TCGA database, we identified overexpression of EGFR and MMP7 in gastric adenocarcinoma, which correlates with unfavorable patient outcomes. Notably, MMP7 expression is closely linked to gastric adenocarcinoma metastasis. Immunohistochemical analysis of clinical gastric adenocarcinoma tissue samples confirmed the association of both EGFR and MMP7 with metastasis, aligning with the findings from bioinformatics analysis. Moreover, our immunohistochemical results revealed a positive correlation between EGFR and MMP7 expression, providing a foundational basis for future endeavors in searching for drug targets to prevent and treat gastric cancer invasion and metastasis.
Domestic Violence Among Women Attending Primary Health Care Centers: Effect on Their Mental and Physical Well-Being, Jeddah, Saudi Arabia
Authors: Wali Razaz , Allhybi Abdulaziz K , Alqerafi Ahmed , Sagim Renad A , Hawsawi Tahani , Malibari Waleed 
Published: November 2023

Abstract
Background
Domestic violence (DV) is a global public health issue and a violation of human rights, affecting one-third of women worldwide. DV survivors often face long-term physical, mental, and psychological health consequences but struggle to disclose such incidents for cultural, personal, or institutional reasons. This study aimed to assess the impact of DV on the well-being of Saudi women attending National Guard Primary Health Care centers.
Methods
A cross-sectional study in the National Guard Primary Health Care Clinics in the western region of Saudi Arabia was conducted from 2022 to 2023. A convenient sampling method was used. The study employed the Norvold Domestic Abuse Questionnaire (NorAQ) to measure the extent of physical, psychological, and sexual abuse among women. In total, 1813 female participants between the ages of 14 and 65 years who met the inclusion criteria were included, and they completed the questionnaire. SPSS (Statistical Package Social Sciences) version 24.0 was used to analyze the data.
Results
The study included 1813 Saudi women with a mean age of 32.2 years. A significant association (p < 0.05) was found between different types of abuse and poor overall health. Women who reported psychological abuse were 56% less likely to report good health than those who did not experience psychological abuse. Similarly, physically abused women were 52% less likely to have good health, while sexually abused women were 41% less likely to report good health. The study also showed a significant association between psychological abuse and depression, insomnia, and feelings of carelessness, with odds ratios of 4.34, 3.22, and 3.37, respectively. Additionally, physical abuse was significantly linked to increased hospital visits, the need for psychological help, depression, and insomnia, with odds ratios of 1.31, 2.78, 3.32, and 2.61, respectively. Furthermore, the study identified a significant association between sexual abuse and the need for psychological help, depression, insomnia, and feelings of carelessness, with odds ratios of 1.82, 2.42, 1.73, and 2.69, respectively.
Conclusion
Raising public awareness about the adverse effects of abuse on women's physical and mental well-being is crucial. Additionally, it is essential to provide primary care physicians with adequate training to identify and address cases of abuse effectively.
Error estimation in current noisy quantum computers
Authors: Aseguinolaza Unai , Sobrino Nahual , Sobrino Gabriel , Jornet-Somoza Joaquim , Borge Juan 
Published: November 2023

Abstract

One of the main important features of the noisy intermediate-scale quantum(NISQ) era is the correct evaluation and consideration of errors. In this paper, we analyze the main sources of errors in current (IBM) quantum computers and we present a useful tool (TED-qc) designed to facilitate the total error probability expected for any quantum circuit. We propose this total error probability as the best way to estimate a lower bound for the fidelity in the NISQ era, avoiding the necessity of comparing the quantum calculations with any classical one. In order to contrast the robustness of our tool we compute the total error probability that may occur in three different quantum models: 1) the Ising model, 2) the Quantum-Phase Estimation (QPE), and 3) the Grover’s algorithm. For each model, the main quantities of interest are computed and benchmarked against the reference simulator’s results as a function of the error probability for a representative and statistically significant sample size. The analysis is satisfactory in more than the 99% of the cases. In addition, we study how error mitigation techniques are able to eliminate the noise induced during the measurement. These results have been calculated for the IBM quantum computers, but both the tool and the analysis can be easily extended to any other quantum computer.
Genotyping of VP6 and NSP4 genes and molecular characterization of NSP4 gene of unusual Rotavirus group A isolated from children with acute gastroenteritis
Authors: Dellis Charilaos , Tatsi Elizabeth-Barbara , Koukou Dimitra-Maria , Filippatos Filippos , Vetouli Evangelia-Eirini , Michos Athanasios , syriopouou Vasiliki 
Published: November 2023

Abstract
Group A Rotavirus (RVA), which causes acute gastroenteritis (AGE) in children worldwide, is categorized mainly based on VP7 (genotype G) and VP4 (genotype P) genes. Genotypes that circulate at < 1% are considered unusual. Important genes are also VP6 (genotype I) and NSP4 (genotype E). VP6 establishes the group and affects immunogenicity, while NSP4, as enterotoxin, is responsible for the clinical symptoms. Aim of this study was to genotype the VP6 and NSP4 genes and molecularly characterize the NSP4 gene of unusual RVA. Unusual RVA strains extracted from fecal samples of children ≤ 16 years with AGE, were genotyped in VP6 and NSP4 genes with Sanger sequencing. Phylogenetics was performed using MEGA 11. In a 15-year period (2007–2021), 54.8% (34/62) of unusual RVA were successfully I and E genotyped. Three different I and E genotypes were identified; I2 (73.5%, 25/34) and E2 (35.3%, 12/34) were the commonest. E3 genotype was detected from 2017 onwards. The uncommon combination of I2-E3 was found in 26.5%(9/34) of the strains and G3-P[9]-I2-E3 was the most frequent G-P-I-E combination (20.6%,7/34). Statistical analysis showed that children infected with E2 strains had a higher relative frequency of dehydration(50%) compared to those with E3 genotype(p = 0.019). Multiple substitutions were detected in NSP4, but their functional effect remains unknown. The results indicate the genetic diversity of RVA strains. Continuous surveillance of the RVA based on the whole genome will provide a better knowledge of its evolution.
Estimated Tsunami Arrival Times for the Ambon Bay Area, Indonesia: Linking Tsunami Hazards Information to the City’s Evacuation Readiness
Authors: Puturuhu Ferad , Syamsidik Syamsidik , Oktari Rina Suryani , Al’ala Musa , Renaldi Teuku Andri , Khalqillah Aulia , Pakoksung Kwanchai , Suppasri Anawat 
Published: November 2023

Abstract

The Ambon Bay Area, with the current population of around 350,000 in Ambon City located along the Bay, has a central function from the perspectives of geography and economic activities in Eastern Indonesia, but also the Bay is surrounded by a number of tectonic and non-tectonic tsunami sources, with insufficient information that could be integrated into a city-wide evacuation procedure for Ambon City. This study is aimed at estimating tsunami arrival times based on deterministic tsunami modeling, assessing tsunami evacuation readiness of the communities and inland facilities for city-wide evacuation. Two main methods are applied in this research, first by simulating a numerically deterministic model of a tsunami, and second by assessing the community’s perceptions on their readiness to evacuate should any tsunami happen. Tsunami simulations were performed using the Cornell Multi-Grid Coupled Tsunami Model (COMCOT). Bathymetry data were taken from GEBCO and Admiralty charts published by PUSHIDROSAL (Hydro-Oceanographic Center, Indonesian Navy). The simulations took four historical tsunamis sources, namely from Tanimbar trough (two events), Weber Sea, and from Banda Detachment. The results show that the shortest arrival time was around 37 minutes and it was indicated at the eastern part of the bay. Meanwhile, at some major populated areas around the bay, the shortest arrival times were between 42 and 56 minutes. However, tsunami evacuation routes in the city have not been fully identified. Only one siren tower is available and it is not enough to reach the whole city area, and only around 20% of the research respondents have participated in tsunami evacuation drills. Most of the respondents were obtained for the tsunami awareness information from places of worship. Essentially, concerns are over the absence of emergency traffic management facilities and insufficient tsunami early warning facilities (such as sirens).
Theoretical study and microcontroller implementation of a non-smooth electromechanical system actuated by a Rayleigh-Duffing oscillator
Authors: Foguem Prosper Kounchie , Nkengne Steve Tchassem , Kingni Sifeu Takougang , Woafo Paul 
Published: November 2023

Abstract

This paper deals with the theoretical and experimental studies of non-smooth electromechanical system (EMS) actuated by Rayleigh-Duffing oscillator (RDO). The RDO exhibits sinusoidal and triangular signals depending on its nonlinear coefficient. The rate-equations of EMS under study are derived thanks to the Kirchhoff and Newton second laws. Based on the Routh-Hurwitz criterion, the stability of the two equilibrium points found are reported where one is unconditionally unstable and other one is stable or unstable based on systems parameters. The influence of the variation of the system parameters on the dynamics of the EMS is numerically studied by using the amplitude curves of the current and displacement of the EMS. Numerical results show that when the RDO excites the EMS with a sinusoidal signal, the movement of the EMS is either periodic oscillations or chaotic oscillations depending on the value of the elasticity coefficient. When the RDO excites the EMS with triangular signal, relaxation oscillations, periodic bursting oscillations or chaotic bursting oscillations are observed in the EMS depending on the value of the elasticity coefficient. The numerical analysis results are confirmed by the microcontroller implementation of EMS actuated by RDO.