bluuebunny/crossref_metadata_2025_split huggingface dataset:
MATERNAL PREGNANCY OUTCOMES IN WOMEN WITH CARDIOMYOPATHY: A SYSTEMATIC REVIEW
Authors: Hilman Feisal , Subhakti M Alvian , Prabowo Rafik 
Published: December 2023

Introduction: Pregnancy poses significant cardiovascular challenges, affecting 1 to 4 of pregnancies due to maternal heart disease. Cardiomyopathies, leading indirect causes of maternal mortality globally, raise concerns during pregnancy, despite limited data on their impact and the accuracy of predictive scores like Carpreg and Zahara. Maternal heart disease, comprising hypertensive disorders and cardiomyopathies, presents substantial risks during pregnancies, driving increased maternal mortality rates. The evolving landscape, marked by improved survival in congenital heart disease and delayed pregnancies with associated comorbidities, necessitates a more nuanced understanding and comprehensive predictive models for tailored care during pregnancy.
Methods: The researchers in this study followed the 2020 Preferred Reporting Items for Systematic Review and Meta-Analysis (PRISMA) guidelines to ensure that their work met the required standards. This was done to ensure the precision and reliability of the conclusions derived from the research.
Result: Our search produced 15 results. After looking at the titles and summaries, we found 11 papers that fit our criteria. At first, we excluded several articles because they were written in review and case report style. But after reading the full papers carefully, we included five papers in our final analysis. These papers included prospective and retrospective studies.
Conclusion: The investigation of pregnant women in Canadian obstetric centers unveiled that cardiac issues affect 16 of pregnancies, primarily with arrhythmias and heart failure, even in lower-risk cases, with complications emerging before birth. The study's precision in evaluating pregnancy-related cardiac risks, leading to a new CARPREG II risk index and emphasizing tailored surveillance and timely referrals, was notable. The ROPAC registry highlighted higher maternal mortality rates, stressing vigilant management throughout pregnancy and after delivery, emphasizing the necessity for specialized care and research advancements in this field.
Barriers to Family Building Among Physicians and Medical Students
Authors: King Zoe , Zhang Qiang , Liang Jane W. , Levy Morgan S. , Plowden Torie C. , Jeelani Roohi , Marshall Ariela L. , Barnett Rebecca , Caban-Martinez Alberto J. , Brown Alyssa , Mueller Claudia M. , Brown-Johnson Cati , Salles Arghavan 
Published: December 2023

ImportancePhysicians and medical students who desire to build families face significant barriers due to the structure and culture of medicine.ObjectiveTo understand the barriers and facilitators to family building for all people in medicine—not only individuals who can become pregnant—through an open-ended, qualitative analysis of survey responses.Design, Setting, and ParticipantsThis qualitative study used a survey conducted in April and May 2021 with a broad sample of physicians and medical students. Participants were recruited through social media, targeting physician and medical student communities. Physicians (residents, fellows, and physicians in independent practice) and medical students of all gender identities and sexual orientations were included. Informed by a postpositivist approach, coding reliability thematic analysis was performed on 3 open-ended survey questions on family-building experiences (what they would do differently, what advice they have for others, and anything else they wished to share).Main Outcomes and MeasuresIdentified themes were mapped to the social-ecological model, a model used in public health to examine how a spectrum of factors is associated with health outcomes.ResultsA total of 2025 people (1860 [92%] women; 299 [15%] Asian, 151 [8%] Black, and 1303 [64%] White; 1730 [85%] heterosexual; and 1200 [59%] physicians who had completed training) responded to at least 1 of 3 open-ended questions. Themes mapped to social-ecological model levels included: (1) cultural, eg, medical training being at odds with family building; (2) organizational, eg, lack of institutional support for the range of family-building routes; (3) interpersonal, eg, impact of social support on family building; and (4) individual, eg, socioeconomic status and other individual factors that facilitate or inhibit family building. Recommendations to improve family-building experiences include implementing family-building curricula at medical schools, providing adequate parental leave for all physicians and medical students who become parents, and providing insurance coverage for all family-building routes.Conclusions and RelevanceIn this qualitative study of physicians and medical students, self-reported barriers to family building were identified at each level of the social-ecological model. Addressing these barriers is critical to creating a more equitable family-building environment for physicians and medical students.
Risk of Falls and Fractures in Individuals With Cataract, Age-Related Macular Degeneration, or Glaucoma
Authors: Tsang Jung Yin , Wright Alison , Carr Matthew J. , Dickinson Christine , Harper Robert A. , Kontopantelis Evangelos , Van Staa Tjeerd , Munford Luke , Blakeman Thomas , Ashcroft Darren M. 
Published: December 2023

ImportanceThree leading disease causes of age-related visual loss are cataract, age-related macular degeneration (AMD), and glaucoma. Although all 3 eye diseases have been implicated with falls and fracture risk, evidence is mixed, with the contribution of different eye diseases being uncertain.ObjectiveTo examine whether people with cataract, AMD, or glaucoma have higher risks of falls or fractures than those without.Design, Setting, and ParticipantsThis cohort study was a population-based study in England using routinely collected electronic health records from the Clinical Practice Research Datalink (CPRD) GOLD and Aurum primary care databases with linked hospitalization and mortality records from 2007 to 2020. Participants were people with cataract, AMD, or glaucoma matched to comparators (1:5) by age, sex, and general practice. Data were analyzed from May 2021 to June 2023.ExposuresFor each eye disease, we estimated the risk of falls or fractures using separate multivariable Cox proportional hazards regression models.Main OutcomesTwo primary outcomes were incident falls and incident fractures derived from general practice, hospital, and mortality records. Secondary outcomes were incident fractures of specific body sites.ResultsA total of 410 476 people with cataract, 75 622 with AMD, and 90 177 with glaucoma were matched (1:5) to 2 034 194 (no cataract), 375 548 (no AMD), and 448 179 (no glaucoma) comparators. The mean (SD) age was 73.8 (11.0) years, 79.4 (9.4) years, and 69.8 (13.1) years for participants with cataract, AMD, or glaucoma, respectively. Compared with comparators, there was an increased risk of falls in those with cataract (adjusted hazard ratio [HR], 1.36; 95% CI, 1.35-1.38), AMD (HR, 1.25; 95% CI, 1.23-1.27), and glaucoma (HR, 1.38; 95% CI, 1.35-1.41). Likewise for fractures, there were increased risks in all eye diseases, with an HR of 1.28 (95% CI, 1.27-1.30) in the cataract cohort, an HR of 1.18 (95% CI, 1.15-1.21) for AMD, and an HR of 1.31 (95% CI, 1.27-1.35) for glaucoma. Site-specific fracture analyses revealed increases in almost all body sites (including hip, spine, forearm, skull or facial bones, pelvis, ribs or sternum, and lower leg fractures) compared with matched comparators.Conclusions and RelevanceThe results of this study support recognition that people with 1 or more of these eye diseases are at increased risk of both falls and fractures. They may benefit from improved advice, access, and referrals to falls prevention services.
Magnetic Bacteriophage‐Engineered Janus Micromotors for Selective Bacteria Capture and Detection
Authors: Cuntín‐Abal Carmen , Bujalance‐Fernández Javier , Yuan Kaisong , Arribi Ana , Jurado‐Sánchez Beatriz , Escarpa Alberto 
Published: December 2023

AbstractHerein, T4‐bacteriophage‐funcionalizated magnetic Janus micromotors are used for the first time for highly selective Escherichia coli (E. coli) recognition and detection. The micromotors propel at speeds of up to 40 µm s−1 in complex biological samples for on‐the‐fly capture of E. coli “strain B”‐thiolated T4 bacteriophage complex. Detection is achieved by a simplified colorimetric readout in connection with gold nanoparticles. The detection limit meets the cut‐off for the fast diagnosis of urinary tract infections. The bacteriophage‐engineered micromotors are tested on bacteria isolated from urine samples and in serum isolated from negative blood cultures from hospital patients with excellent selectivity and reliability. The new strategy described here holds considerable promise for the multiplexed detection of a myriad of bacteria strains using tailored bacteriophages. Technically, this is the first microplate‐reader integrated micromotor approach, crossing another bridge from the research lab to the practical use of micromotors. Specifically, these results represent a qualitative step forward in the use of micromotor technology with sophisticated functionalization for fast bacteria screening in clinical settings.
Concentration of clarified pool by single‐pass tangential flow filtration to improve productivity of protein A capture step: Impact of clarification strategies
Authors: Rahane Santosh B. , Gupta Akshat , Szymanski Philip , Kinzlmaier Dana , McGee Patrick , Goodrich Elizabeth 
Published: December 2023

AbstractProtein A capture chromatography remains a high‐cost and relatively low‐productivity step for downstream processing of monoclonal antibodies. As bioprocessing transitions toward intensified processes, maximizing the efficiency of individual steps is key to achieving economic targets. This study was performed to assess the impact of inline concentration of clarified cell culture fluid (CCF), using single‐pass tangential flow filtration, on protein A chromatography purification productivity. CCF with varying levels of impurities and turbidity were obtained dependent upon the clarification method. These CCFs were concentrated and processed over a protein A capture step. Productivity increases of 1.8‐ to 2.6‐fold were achieved as compared to a protein A capture step with no CCF concentration. Achieving such targeted improvements requires careful consideration of the multiple components in the clarification strategy before implementation.
Potentially functional genetic variants in ferroptosis‐related CREB3 and GALNT14 genes predict survival of hepatitis B virus‐related hepatocellular carcinoma
Authors: Zhan Shicheng , Qiu Moqin , Wei Xueyan , Wei Junjie , Qin Liming , Jiang Binbin , Wen Qiuping , Chen Peiqin , Lin Qiuling , Wei Xiaoxia , Zhou Zihan , Jiang Yanji , Liang Xiumei , Li Runwei , Liu Yingchun , Yu Hongping 
Published: December 2023

AbstractBackgroundFerroptosis is a known crucial player in the development of cancers. However, the effect of single nucleotide polymorphisms (SNPs) in ferroptosis‐related genes on survival in hepatitis B virus (HBV)‐related hepatocellular carcinoma (HBV‐HCC) patients remains unknown.MethodsWe used two‐stage multivariable Cox proportional hazards regression analyses to estimate the associations between 48,774 SNPs in 480 ferroptosis‐related genes and overall survival (OS) of 866 HBV‐HCC patients.ResultsWe identified that two potentially functional SNPs (CREB3 rs10814274 C > T and GALNT14 rs17010547 T > C) were significantly independently associated with the OS of HBV‐HCC patients (CT + TT verse CC, hazards ratio (HR) = 0.77, 95% confidence interval (CI) = 0.67–0.89, p < 0.001 for rs10814274 and TC + CC verse TT, HR = 0.66, 95% CI = 0.53–0.82, p < 0.001 for rs17010547, respectively). Additional joint assessment of protective genotypes of these two SNPs showed that patients with 1–2 protective genotypes had a significantly better OS compared with those carrying 0 protective genotypes (HR = 0.56, 95% CI = 0.45–0.70, p < 0.001). Moreover, the expression quantitative trait loci (eQTL) analysis revealed that the survival‐associated SNP rs10814274 T allele was significantly correlated with reduced CREB3 transcript levels in both normal liver tissues and whole blood cells, while the GALNT14 rs17010547 C allele had a significant correlation with increased GALNT14 transcript levels in whole blood cells.ConclusionThese results suggest that genetic variants of CREB3 and GALNT14 may affect the survival of HBV‐HCC patients, likely via transcriptional regulation of respective genes. However, further studies are required to confirm these findings.
Construction of immune score and its prognostic value in invasive lobular carcinoma of the breast using computational pathology analysis
Authors: Wang Liye , Sun Peng , Xu Fei , Zheng Qiufan , Jiang Kuikui , Hong Ruoxi , Wang Shusen 
Published: December 2023

AbstractBackgroundPrevious studies have shown that high level of TILs in invasive lobular carcinoma (ILC) is associated with poor prognosis, contrary to that in TNBC and HER2‐positive breast cancer.MethodsThe densities of six immune cell markers and three immune checkpoints in the ILC microenvironment were detected by computational pathology analysis. Then, the LASSO cox regression model was used to construct an immune score (IS) and further evaluate its prognostic value.ResultsIn our ILC cohort, the low density of CD4, CD8, CD20, CD56, CD68, FOXP3, PD‐1, and PD‐L1 had significantly longer disease‐free survival (DFS) and overall survival (OS); however, the low density of CTLA‐4 was associated with shorter DFS and OS. Based on this, an IS was constructed, and patients with low‐IS had significantly prolonged DFS (p < 0.0001) and OS (p < 0.0001). Multivariate analysis revealed that IS was an independent prognostic indicator for DFS and OS. Further analysis showed that IS may increase the prognostic value of TNM stage. We further explored the prognostic role of CD68 and FOXP3 in the transcriptional level and the corresponding ISm in the METABRIC dataset, and found that low proportion of CD68 and FOXP3 and their ISm were associated with longer OS, and ISm was also an independent prognostic factor for OS.ConclusionIS was a promising biomarker to distinguish the prognosis in ILC patients.
The Regentime stem cell procedure, successful treatment for a Charcot–Marie–Tooth disease case
Authors: Abi Chahine Nassim H. , Mansour Vanessa J. , Nemer Lea I. , Najjoum Cynthia F. , El Asmar Elsa A. , Boulos Rita T. 
Published: December 2023

Key Clinical MessageThis report highlights the successful treatment of a Charcot–Marie–Tooth disease case using the Regentime stem cell procedure, suggesting its potential as a promising therapeutic approach for patients suffering from this challenging condition.
Recent Advance in the C−F Bond Functionalization of Trifluoromethyl Aromatic and Carbonyl Compounds
Authors: Liu Jia‐Wei , Li Shi‐Yu , Xu Jun , Xu Hua‐Jian 
Published: December 2023

AbstractThe selective C−F bonds functionalization in available trifluoromethyl compounds is an economic route for obtaining high‐value organic fluorine compounds. However, due to the high C−F bonds dissociation energy in trifluoromethyl group, the strength of the bond decreases continuously during defluorination, posing a challenge in modifying such molecules without over‐conversion. Over the past few years, there has been significant progress in developing efficient methods for constructing difluoromethylene unit, using approaches such as radical chemistry, photochemistry, electrochemistry, and organometallic chemistry. These methods involve difluorocarbon radicals, difluorocarbon cations, difluorocarbon anions, and trifluoromethyl carbenes as intermediates. In this review, we summarized the recent five years of research achievements in this field for selective single C−F bond cleavage in trifluoromethyl aromatic and carbonyl compounds to gain diverse difluoromethylene‐containing organic molecules via different intermediate strategies.
Single‐ and multi‐GPU computing on NVIDIA‐ and AMD‐based server platforms for solidification modeling application
Authors: Halbiniak Kamil , Meyer Norbert , Rojek Krzysztof 
Published: December 2023

SummaryThis work explores the performance of single‐ and multi‐GPU computing on state‐of‐the‐art NVIDIA‐ and AMD‐based server‐class hardware using various programming interfaces to accelerate a real‐world scientific application for solidification modeling based on the phase‐field method. The main computations of this memory‐bound application correspond to 20 stencils computed across grid nodes. We investigate the application's scalability for two basic schemes of organizing computation: without and with hiding data transfers behind computation, combined with using either peer‐to‐peer inter‐GPU data transfers through NVIDIA NVLink and AMD Infinity interconnects or communication over the PCIe and main memory. Among the studied programming interfaces is CUDA, HIP, and OpenMP Accelerator Model. While the first two are designed to write the codes for a specific hardware platform, OpenMP enables code portability between NVIDIA and AMD GPUs. The resulting performance is experimentally assessed on computing platforms containing NVIDIA V100 (up to 8 GPUs) and A100 (one GPU), as well as AMD MI210 (one device) and MI250 (up to 8 logical GPUs).
A case of early gastric cancer with metastatic recurrence following curative endoscopic submucosal dissection
Authors: Morita Yukihiro , Kimura Hidenori , Inatomi Osamu , Noguchi Akito , Shintani Shuhei , Imai Takayuki , Ohno Masashi , Matsumoto Hiroshi , Nishida Atsushi , Kaida Sachiko , Tani Masaji , Kushima Ryoji , Andoh Akira 
Published: December 2023

AbstractA 70‐year‐old man was diagnosed with early gastric cancer with ulcerative findings. Endoscopic submucosal dissection as an absolute indication was performed, and en bloc resection was achieved. Pathological examination revealed a well‐differentiated adenocarcinoma, 3 × 2 mm in size, intramucosal, with an ulcerative scar, no lymphovascular invasion, and a tumor‐free margin. We diagnosed it as a curative resection and followed up with annual endoscopy. Sixteen months after endoscopic submucosal dissection, esophagogastroduodenoscopy revealed a singular ulcer scar; however, serum carcinoembryonic antigen level was elevated. Computed tomography scan showed wall thickening of the gastric antrum and an irregular mass on the dorsal side. Additionally, 18F‐fluorodeoxyglucose positron emission tomography/coomputed tomography showed 18F‐fluorodeoxyglucose uptake in the gastric antrum, irregular mass, and liver. Endoscopic ultrasonography revealed an internally heterogeneous mass in the gastric antrum region extending from the submucosal layer to the muscularis propria layer. Using an endoscopic ultrasonography‐guided fine needle biopsy with a 22‐gauge needle for the mass, we diagnosed local recurrence with the submucosal tumor‐like appearance, lymph node metastasis, and liver metastases. Unfortunately, the patient died of gastric cancer 3 months after the diagnosis. Here, we report a rare case of local recurrence in the submucosal layer, lymph node metastasis, and liver metastases 16 months after curative endoscopic submucosal dissection.
Variability in evapotranspiration in the Andean páramo as influenced by fog and rainfall
Authors: Berrones Gina , Crespo Patricio , Carrillo‐Rojas Galo , Wilcox Bradford P. , Célleri Rolando 
Published: December 2023

AbstractTropical mountains such as the páramos of the Andes, which serve as ‘water towers’ for local communities and downstream cities, are important areas for early detection of climate change. Here, fog and low‐intensity rainfall are very common and play a key role in ecohydrological processes. Although evapotranspiration (ET) represents an important part of the water cycle, how ET and fog processes interact and how they affect páramo vegetation and water resources availability are poorly understood. This study investigated the effects of foggy (fog only) and mixed (fog and rainfall) conditions on ET. To determine whether fog significantly reduces ET, we compared ET and meteorological data under these two conditions with those during dry days. We found that on foggy days, when fog was most prevalent in the early morning, ET declined on average by 4% and net radiation (Rn) by 9.2%. Under mixed conditions, daily ET declined by 42% and Rn by 33%. In the páramo, where mean annual precipitation and ET are 1210 and 635 mm, respectively, the estimated annual reduction in ET due to fog and rainfall combined is between 77 and 174 mm. We found that during fog and rainfall mixed conditions, solar radiation was reduced, consequently constraining the energy available for ET while sustaining high relative humidity, ultimately reducing water loss. Our findings, which suggest that the presence of fog and low‐intensity rainfall restricts water losses by evaporative demand, contribute to a better understanding of the ecohydrological importance of these water inputs in the Andes.
A green dye wastewater treatment process: Complex extraction of Telon yellow 4R from dye wastewater and its application in nylon fabric dyeing
Authors: Yu Chengbing , Zheng Zhe , Wang Qingxuan 
Published: December 2023

AbstractComplex extraction, which has the characteristics of high efficiency and selectivity of chemicals, has unique advantages in dye wastewater treatment. In the paper, a green closed‐loop dye wastewater treatment route for dyeing industry is re‐evaluated by studying the complex extraction and stripping of Telon yellow 4B, and dyeing test of regenerated dye. FT‐IR characteristic peaks of the initial organic phase and the regenerated organic phase are consistent, and the dye can be migrated from the loaded organic phase to the aqueous phase after stripping. The concentration of dye in the aqueous phase and extraction conditions have a significant effect on extraction rate, especially the aqueous‐organic phase ratio and the pH value of the aqueous phase. Meanwhile, the stripping conditions have a marked impact on stripping rate, among which NaOH dosage is an important factor. The regenerated dye solution and the freshly prepared dye solution at same concentration have the same color shade and K/S value, and the color fastness of dyed fabrics is all above Grade 4. High extraction rate, high stripping rate, excellent reusability of regenerated organic phase, and the dyeing performance of the regenerated dye prove that complex extraction is a green dye wastewater treatment process with the practical feasibility.