bluuebunny/crossref_metadata_2025_split huggingface dataset:
Evidence of a genetic background predisposing to complex regional pain syndrome type 1
Authors: Shaikh Samiha S , Goebel Andreas , Lee Michael C , Nahorski Michael S , Shenker Nicholas , Pamela Yunisa , Drissi Ichrak , Brown Christopher , Ison Gillian , Shaikh Maliha F , Kuttikat Anoop , Woods William A , Dixit Abhishek , Stouffer Kaitlin , Clarke Murray CH , Menon David K , Woods C Geoffrey 
Published: October 2023

BackgroundComplex regional pain syndrome type 1 (CRPS-1) is a rare, disabling and sometimes chronic disorder usually arising after a trauma. This exploratory study examined whether patients with chronic CRPS-1 have a different genetic profile compared with those who do not have the condition.MethodsExome sequencing was performed to seek altered non-synonymous SNP allele frequencies in a discovery cohort of well-characterised patients with chronic CRPS-1 (n=34) compared with population databases. Identified SNP alleles were confirmed by Sanger sequencing and sought in a replication cohort (n=50). Gene expression of peripheral blood macrophages was assessed.ResultsIn the discovery cohort, the rare allele frequencies of four non-synonymous SNPs were statistically increased. The replication cohort confirmed this finding. In a chronic pain cohort, these alleles were not overexpressed. In total, 25 out of 84 (29.8%) patients with CRPS-1 expressed a rare allele. The SNPs were rs41289586 inANO10, rs28360457 inP2RX7, rs1126930 inPRKAG1and rs80308281 inSLC12A9. Males were more likely than females to have a rare SNP allele, 8 out of 14 (57.1%) vs 17 out of 70 (24.3%) (Fisher’s p=0.023).ANO10,P2RX7,PRKAG1andSLC12A9were all expressed in macrophages from healthy human controls.ConclusionA single SNP in each of the genesANO10, P2RX7, PRKAG1andSLC12A9was associated with developing chronic CRPS-1, with more males than females expressing these rare alleles. Our work suggests the possibility that a permissive genetic background is an important factor in the development of CRPS-1.
Characteristics of naturally formed semitruck platoons on interstate highways and their implications for truck platooning field deployment
Authors: Hu Xiaoqiang , Peng Cheng , Bao Jieyi , Jiang Yi , Li Shuo 
Published: October 2023

This paper presents an effort to address urgent issues associated with semitruck platooning. The weigh-in-motion data were first examined to determine the characteristics of naturally formed semitruck platoons. A safety-based two-vehicle platoon model was then utilized to determine the critical headways for assessing the safety of semitruck platooning in various driving scenarios. The possibilities for passenger vehicles to cut into semitruck platoons were assessed using actual vehicle headway data. Finally, the potential impacts of semitruck platooning on typical interstate highway pavements were assessed using finite element analysis. Most semitruck platoons consist of two to three vehicles. An optimal platoon gap of 0.94 s was identified for connected and automated semitruck platooning. The potential impacts of truck platooning on concrete pavement were negligible for a platoon gap greater than 0.2 s. The maximum possible impact was less than 4% in terms of the service life reduction for interstate asphalt pavement.
PRIMA-1 synergizes olaparib-induced cell death in p53 mutant triple negative human breast cancer cell line via restoring p53 function, arresting cell cycle, and inducing apoptosis
Authors: Zaza Mohamed , Rashed Mohammed H. , Elrefaey Hesham , Hassan Memy H. , Abo-Salem Osama M. , El-Sayed El-Sayed M. 
Published: October 2023

This study concerned with assessing the effect of restoring p53 using PRIMA-1 on the anti-cancer activity of olaparib against TP53-mutant triple negative breast cancer (TNBC) cells and exploring the optimum synergistic concentrations and the underlying mechanism. Human BC cell lines, MDA-MB-231 with mutated TP53 gene, and MCF-7 with wild-type TP53 gene were treated with olaparib and/or PRIMA-1. The IC50 value for olaparib was significantly decreased by PRIMA-1 in MDA-MB-231 cells compared to MCF-7 cells. Contrary to MCF-7 cells, co-treatment with olaparib and PRIMA-1 had a synergistic anti-proliferative effect in MDA-MB-231 at all tested concentrations with the best synergistic combination at 45 and 8.5 µM, respectively, and furthermore PRIMA-1 enhanced olaparib-induced apoptosis. This synergistic apoptotic effect was associated with a significant boost in mRNA expression of TP53 gene, cell cycle arrest at G2/M phase, modulation of BRCA-1, BAX and Bcl2 proteins expressions, and induction of active caspase-3. These results present a clue for the utility of combined olaparib and PRIMA-1 in treatment of TP53-mutant TNBC invitro. PRIMA-1 triggers olaparib-induced MDA-MB-231 cell death in a synergistic manner via restoring TP53, decreasing BRCA-1 expression, cell cycle arrest, and enhancement of apoptosis via p53/BAX/Bcl2/caspase 3 pathway.
Construction of All Multilayer Monolithic RSMTs and Its Application to Monolithic 3D IC Routing
Authors: Dewan Monzurul Islam , Lin Sheng-En David , Kim Dae Hyun 
Published: October 2023

Monolithic three-dimensional (M3D) integration allows ultra-thin silicon tier stacking in a single package. The high-density stacking is acquiring interest and is becoming more popular for smaller footprint areas, shorter wirelength, higher performance, and lower power consumption than the conventional planar fabrication technologies. The physical design of M3D integrated circuits requires several design steps, such as three-dimensional (3D) placement, 3D clock-tree synthesis, 3D routing, and 3D optimization. Among these, 3D routing is significantly time consuming due to countless routing blockages. Therefore, 3D routers proposed in the literature insert monolithic interlayer vias (MIVs) and perform tier-by-tier routing in two substeps. In this article, we propose an algorithm to build a routing topology database (DB) used to construct all multilayer monolithic rectilinear Steiner minimum trees on the 3D Hanan grid. To demonstrate the effectiveness of the DB in various applications, we use the DB to construct timing-driven 3D routing topologies and perform congestion-aware global routing on 3D designs. We anticipate that the algorithm and the DB will help 3D routers reduce the runtime of the MIV insertion step and improve the quality of the 3D routing.
Estimation of hourly solar irradiation on tilted surfaces
Authors: Belsky Aleksey , Glukhanich Dmitry , Sutikno Tole , Hatta Jopri Mohd 
Published: October 2023

Tilted photovoltaic panel (PVP) are extensively utilized in solar power installations. To model and design them, you must understand the solar irradiation on a tilted surface over time scales of an hour, day, week, month, or other period. However, most meteorological stations only record global horizontal irradiance (GHI). In this research, a method is proposed for translating hourly worldwide horizontal irradiation from the NASA POWER database into hourly global sun irradiation on a tilted surface utilizing regression analysis methods and numerical modeling methods based on an isotropic model of solar irradiation. In addition, this work proposes a method for establishing the regression reliance of the diffuse transmittance index on the clearness index for geographic areas where this relationship has not yet been empirically proven. To assess effectiveness, the results of the proposed technique and other authors' methods are compared with monthly average NASA POWER climatological data using evaluation methods such as mean bias error (MBE), mean absolute bias error (MABE), and root-mean-square error (RMSE). The study's findings can be used to construct, optimize, or anticipate the functioning of solar power facilities at any angle of tilt and in any geographic area.
Abstract 047: Understanding Patient And Practitioner Use Of The US Validated Device Listing (VDL™)
Authors: Ramkissoon Nar , McReynolds Matthew 
Published: October 2023

Hypertension is the leading preventable risk factor for cardiovascular disease, yet according to research, only one in four adults with hypertension have their blood pressure (BP) controlled. Clinical guidelines recommend the use of self-measured blood pressure to improve (SMBP) BP control among individuals with hypertension, however, research has shown that most BP devices available for purchase are not validated, raising concerns about the accuracy of BP readings taken by a patient. In response, the American Medical Association (AMA) launched the US Validated Device Listing (VDL)™, the first U.S. list of BP measurement devices developed to assist physicians and patients in identifying devices that have been validated for clinical accuracy.
The VDL website, validateBP.org, has had more than 660,000 visitors since it launched in 2020. There are currently 60 devices from 16 manufacturers listed on the site. To better understand awareness and use of SMBP, the VDL, and validated devices, the AMA commissioned a survey from a panel of practitioners and patients. Results from over 300 practitioners indicate that while the vast majority of primary care physicians recommend at-home blood pressure devices to their patients (99%; 151/152), and most are aware of validation and accuracy concerns (58%; 88/152), less than one third of primary care physicians were aware of the Validated Device Listing (29%; 44/152).
In a survey of over 300 patients, data indicate that over half prefer to measure blood pressure using a personal device (55%; 166/301), and among self-identified hypertensive patients with a device, the vast majority view accuracy of blood pressure readings as the most important factor when comparing blood pressure devices (83%; 146/176).
Results from the small-scale survey point to the continued need for validation resources for SMBP devices, and the need to continue developing a greater awareness of the VDL amongst practitioners and patients.
Abstract P179: Nano- And Microplastic-enriched Diets Affect Inflammation And Target Organ Damage In Hypertension
Authors: Fuckert Franziska , Rauch Ariana , Anandakumar Harithaa , Bartolomaeus Hendrik , Wilck Nicola 
Published: October 2023

Plastic particle pollution is a major environmental challenge worldwide. Micro (MP)- and nanoplastic (NP) particles appear ubiquitously and have been detected in food, drinking water, human feces and blood. Once absorbed, plastic particles can alter the gut microbiome and induce inflammation. Current research primarily focuses on the impact on healthy organisms. Yet, a deeper understanding of the impact of MP and NP on health-to-disease transition and their impact on cardiovascular disease is missing. This project aims to investigate the impact of MP and NP in experimental hypertension.
Ten-week-old male NMRI mice were randomized to receive the following particle-enriched diets: a polystyrene MP (particle size 5 μm) (20 μg/g chow, 100 μg/l via drinking water), NP (particle size 100nm) (20 μg/g chow,100 μg/l via drinking water) or control (C) for four weeks. Subsequently, hypertension (HTN) was induced by Angiotensin II (AngII) infusion (1000 ng/kg*min s.c., osmotic minipump). Sham-treated non-hypertensive mice served as controls. During hypertension induction mice were continued on their respective diets. After 14 days, we assessed hypertensive organ damage and inflammation.

AngII-treated mice developed hypertension an increased cardiac hypertrophy index (Sham vs HTN: 10.1 vs 10.7 mg/mm tibia), and lower cardiac output (HTN vs Sham: 15.5 vs 19.9 ml/min, echocardiography). MP fed mice showed upregulated mRNA expression of marker genes for renal fibrosis (
Ctgf; Acta
) in both homeostasis (ddCT
-2
for MP: 2.7; 6.6) and HTN (ddCT
-2
3.2 (MP) vs. 2.3 (C); 14.2 (MP) vs 11.2 (C)), as well as enhanced proinflammatory gene expression (
Ccl2; IL1b
) in HTN (ddCT
-2
7.4 (MP) vs 4.0 (C); 5.8 (MP) vs 4.3 (C)). Similarly, NP fed mice showed altered mRNA expression for e.g.
IL1b
(ddCT
-2
for NP: 3.6). Flow cytometric analysis shows a proinflammatory immune response to MP and NP, e.g. an increase of circulating neutrophils (HTN C vs. MP: 24.7% vs 50.0% of CD45+) and Ly6C
hi
monocytes (Homeostasis C vs NP: 2.4 vs 3.2% of CD45+).

Conclusion:
MP and NP affect the inflammatory response and organ damage in hypertension. Our further investigations will help to shed light on the impact of this ubiquitous environmental influence on hypertension, associated organ damage and the microbiome.
Abstract P228: Beyond The Basics: Resistant Hypertension In A Case Of Acromegaly
Authors: Shah Hriday , Bharmal Vahid , Shingala Jay , Tummala Nayanika C , Gupta Varnika 
Published: October 2023

Introduction:
Acromegaly is a rare pituitary disorder associated with hypertension. Patients with Acromegaly have a higher incidence of hypertension with age.

Case Presentation:
A 50-year-old female with resistant hypertension on 4 antihypertensives (Enalapril, Amlodipine, Metoprolol, and Chlorthalidone) for 5 years presented with Epistaxis and Blood Pressure (BP) of 210/120 mm Hg at a Tertiary care center. Intravenous Labetalol was given, reducing BP to 160/90 mmHg. The patient had fleshy lips and nose, prominent supraorbital ridges, acral enlargement, macroglossia, hyperhidrosis, and arthralgia. Investigations showed a Fasting blood sugar level of 176 mg/dL, an HbA1c level of 8.9%, a serum creatinine level of 1.0 mg/dL, an SGPT level of 42 U/L, a serum sodium/potassium level of 142/4.1 mmol/L and a triglyceride level of 274 mg/dL. Renal artery Doppler was normal, while Echocardiography revealed left ventricular hypertrophy with an ejection fraction of 55%.

Specific Investigations showed elevated Insulin-like Growth factor-1 (IGF1) levels of 604 ng/mL (normal range: 44-227 ng/mL), basal Growth Hormone (GH) 5.75 ng/mL, post-glucose GH 3.83 ng/mL, serum cortisol 8.4 μg/dL, and her prolactin levels and thyroid profile were both normal. A hypointense Sella mass measuring 0.8 cm x 1.5 cm x 1.2 cm was found on a pituitary MRI, which helped to confirm the diagnosis of Acromegaly.
The patient was managed with Octreotide, Cabergoline, and Metformin. Spironolactone 50 mg daily was added for BP control. After 15 days, BP reduced to 140/80 mm Hg. She refused transsphenoidal pituitary resection and was planned for long-acting Octreotide.

Discussion:
This case features Acromegaly associated resistant hypertension. Research suggests that hypertension in Acromegaly occurs due to excess GH/IGF-1 leading to fluid expansion, vascular resistance, and sodium retention. Spironolactone improves blood pressure, indicating a potential role for epithelial sodium channels in GH-induced sodium retention. This finding was evident in our case as well as in previous studies.

Conclusion:
This case demonstrates that acromegaly-induced Resistant hypertension can be managed with appropriate treatment, including Spironolactone.
Abstract P378: Expression Of Micro-rna 221, 222 And 223 In Individuals Suffering From Ischemic Stroke Due To Hypertensive Emergency
Authors: Vilela-Martin Jose F , Oliveira de Andrade Days , Cosenso-Martin Luciana , Yugar Toledo Juan C 
Published: October 2023

Hypertensive crisis can account for damage on target organs characterizing hypertensive emergencies (HE). Ischemic Stroke (IS) is among these injuries. Expression of microRNAs (miRNAs) is considered the possible factors related to HE. This study evaluated the association of expression of miRNAs 221, 222 and 223 in patients suffering ischemic stroke due to HE. Material and Methods
Thirty and four patients with IS due to hypertensive emergency (IS-HE), 33 individuals with IS without HE (IS), 31 controlled hypertensive (CHT) and 33 normotensive (NT) individuals were studied. The expression of miRNAs 221, 222 and 223 was performed by RT-q PCR (real-time quantitative polymerase chain reaction). Results
Systolic and diastolic blood pressure were significantly higher in the IS-HE compared to IS, CHT and NT groups (162/99 mmHg vs 140/87, 128/69 and 129/82 mmHg, respectively; p <0.05). The miRNA-221 expression was higher in the IS-HE group compared to the IS, CHT and NT groups (4.23 vs 2.44, 1.35 and 1.05, respectively; p<0.0001). There was overexpression of miRNA-223 in the IS-HE and IS groups compared to CHT and NT groups (1.56 and 1.73 vs 0.13 and 0.66; p < 0.001). For miRNA-222 there was overexpression in the IS-HE, IS, and NT groups compared to the CHT group (P<0.0001 for all). Conclusions
This study provides evidence of the miRNAs participation in the pathophysiology of ischemic stroke due hypertensive emergency, thus assuring that the increased expression of miR-221 and miR-223 determines a greater chance of the individual presenting IS due HE. The miRNAs 221 and 223 are related to endothelial damage; thus, their overexpression shows the participation of endothelial dysfunction in cases of acute blood pressure elevation.
National Trends in Mortality and Urgent Dialysis after Acute Hypertension in Japan From 2010 Through 2019
Authors: Matsuki Hisazumi , Genma Taku , Mandai Shintaro , Fujiki Tamami , Mori Yutaro , Ando Fumiaki , Mori Takayasu , Susa Koichiro , Iimori Soichiro , Naito Shotaro , Sohara Eisei , Rai Tatemitsu , Fushimi Kiyohide , Uchida Shinichi 
Published: October 2023

BACKGROUND:
Despite increasing incidences of hypertension, recent trends in mortality and urgent dialysis following acute hypertension (AHT) remain undetermined.

METHODS:

This retrospective observational cohort study evaluated 50 316 hospitalized AHT patients from 2010 to 2019, using an administrative claims database in Japan. We examined trends in incidence, urgent dialysis, mortality, and its risk factors using Poisson regression models. Using
International Classification of Disease and Related Health Problems, 10th Revision
codes, AHT was categorized into 5 spectrums: malignant hypertension (
n
=1792), hypertensive emergency (
n
=17 907), hypertensive urgency (
n
=1562), hypertensive encephalopathy (
n
=6593), and hypertensive heart failure (HHF;
n
=22 462).

RESULTS:

The median age of the patients was 76 years, and 54.9% were women. The total AHT incidence was 70 cases per 100 000 admission year. The absolute death rate increased from 1.83% (95% CI, 1.40–2.40) to 2.88% ([95% CI, 2.42–3.41]; Cochran-Armitage trend test,
P<
0.0001). Upward trends were observed in patients aged ≥80, with lean body mass index ≤18.4, and with HHF. Urgent dialysis rates increased from 1.52% (95% CI, 1.12–2.06) to 2.60% (2.17–3.1; Cochran-Armitage trend test;
P
=0.0071) in 48 235 patients, excluding maintenance dialysis patients. Older age, men, lean body mass, malignant hypertension, HHF, and underlying chronic kidney disease correlated with higher mortality risk; greater hospital volume correlated with lower mortality risk; and malignant hypertension, HHF, diabetes, chronic kidney disease, and scleroderma correlated with a higher risk of urgent dialysis.

CONCLUSIONS:
Mortality and urgent dialysis rates following AHT have increased. Aging, complex comorbidities, and HHF-type AHT contributed to the rising trend of mortality.
Ismene, Interrupted
Authors: Kim Erynn 
Published: October 2023

Abstract
This article studies the usage of the particle μέν as a discourse marker in the speech of Antigone and of Ismene in Sophocles’ Antigone, focusing on the prologue and the final dialogue between the two sisters. By demonstrating how the discursive practices of the sisters reflect their respective styles of reasoning, particularly through their differing usages of the particle μέν, this article explores how the construction of μέν solitarium can reveal what is left unsaid in order to show how the sisters engage in a coded conversation before Creon in their final dialogue, ultimately working in solidarity to resolve their fates, however tragic.
What about Model Data? Best Practices for Preservation and Replicability
Authors: Schuster Douglas C. , Mayernik Matthew S. , Mullendore Gretchen L. , Marquis Jared W. 
Published: October 2023

Abstract
It has become common for researchers to make their data publicly available to meet the data management and accessibility requirements of funding agencies and scientific publishers. However, many researchers face the challenge of determining what data to preserve and share and where to preserve and share those data. This can be especially challenging for those who run dynamical models, which can produce complex, voluminous data outputs, and have not considered what outputs may need to be preserved and shared as part of the project design. This manuscript presents findings from the NSF EarthCube Research Coordination Network project titled “What About Model Data? Best Practices for Preservation and Replicability” (https://modeldatarcn.github.io/). These findings suggest that if the primary goal of sharing data are to communicate knowledge, most simulation-based research projects only need to preserve and share selected model outputs along with the full simulation experiment workflow. One major result of this project has been the development of a rubric, designed to provide guidance for making decisions on what simulation output needs to be preserved and shared in trusted community repositories to achieve the goal of knowledge communication. This rubric, along with use cases for selected projects, provide scientists with guidance on data accessibility requirements in the planning process of research, allowing for more thoughtful development of data management plans and funding requests. Additionally, this rubric can be referred to by publishers for what is expected in terms of data accessibility for publication.
Transformative Ecological and Human Impacts from Diminished Sea Ice in the Northern Bering Sea
Authors: Overland James E. , Siddon Elizabeth , Sheffield Gay , Ballinger Thomas J. , Szuwalski Cody 
Published: October 2023

Abstract
Our goal is to tie climate-scale meteorology to regional physics and ecosystem changes and demonstrate a few resulting impacts to which regional peoples are having to respond in the Alaskan Bering Strait region. The sea ice loss events in the winters of 2017/18 and 2018/19 initiated a series of marine environmental, ecological, and industrial changes through a chain of connected events from jet-stream meanders, storms, southerly winds, warmer sea temperatures, and minimum sea ice cover. Resulting impacts continue as coastal communities respond to ongoing nutritional, cultural, and economic challenges. Global warming potentially initiated these events through a weakened atmospheric Arctic Front. Ecological shifts included a transition/reorganization of the Bering Strait regional marine ecosystem. Subsequent changes included shifts in zooplankton species, increases in large-bodied, predatory fish species moving northward, an ice seal unusual mortality event, and seven consecutive years of multispecies seabird die-offs. These changes in the marine ecosystem create a serious food security concern. Ongoing impacts include large, toxic harmful algal blooms and coastal erosion. Recent changes to the maritime industries of the transboundary waters of the Bering Strait include increased industrial ship traffic, planned development of the Port of Nome, and northward proximity of foreign fishing activity. Projections for the next decades are for an increasing frequency of low sea ice years and continuing ecosystem and industrial transitions that contribute to increasing economic and food security concerns for the 16 coastal communities that compose the Bering Strait region.

Significance Statement
Extreme events in the atmosphere/oceans and resultant record sea ice minimums in 2018 and 2019 were manifested in marine ecosystem transitions and maritime industry impacts. This led to ongoing concerns over the food safety and food security of marine resources essential to the nutritional, cultural, and economic well-being of Alaskan coastal communities of the Bering Strait region. Persistent weakening of the Arctic Front may signal an increased frequency of low sea ice events into the next decades.