bluuebunny/crossref_metadata_2025_split huggingface dataset:
It’s SNARC o’ clock: manipulating the salience of the context in a conceptual replication of Bächtold et al.’s (1998) clockface study
Authors: Mingolo Serena , Prpic Valter , Mariconda Alberto , Brugger Peter , Drack Thekla , Bilotta Eleonora , Agostini Tiziano , Murgia Mauro 
Published: October 2023

AbstractThe Spatial-Numerical Association of Response Codes (SNARC) effect consists in faster left-/right-key responses to small/large numbers. (Bächtold et al., Neuropsychologia 36:731–735, 1998) reported the reversal of this effect after eliciting the context of a clockface—where small numbers are represented on the right and large numbers on the left. The present study investigates how the salience of a particular spatial-numerical context, which reflects the level of activation of the context in working memory, can alter Spatial Numerical Associations (SNAs). Four experiments presented the clockface as context and gradually increased its salience using different tasks. In the first two experiments (low salience), the context was presented at the beginning of the experiment and its retrieval was not required to perform the tasks (i.e., random number generation in Experiment 1, magnitude classification and parity judgement in Experiment 2). Results revealed regular left-to-right SNAs, unaffected by the context. In Experiment 3 (medium salience), participants performed magnitude classification and parity judgement (primary task), and a Go/No-go (secondary task) which required the retrieval of the context. Neither the SNARC effect nor a reversed-SNARC emerged, suggesting that performance was affected by the context. Finally, in Experiment 4 (high salience), the primary task required participants to classify numbers based on their position on the clockface. Results revealed a reversed SNARC, as in (Bächtold et al., Neuropsychologia 36:731–735, 1998). In conclusion, SNARC is disrupted when the context is retrieved in a secondary task, but its reversal is observed only when the context is relevant for the primary task.
Drug levels of VEDOLIZUMAB in patients with pediatric-onset inflammatory bowel disease in a real-life setting
Authors: Hemming-Harlo Maria , Merras-Salmio Laura , Nikkonen Anne , Kolho Kaija-Leena 
Published: October 2023

AbstractVedolizumab (VDZ) is used off-label in pediatric inflammatory bowel disease (PIBD). There are less data on drug levels to achieve and maintain remission in children. We aimed to study vedolizumab (VDZ) trough levels in a pediatric population in a real-life setting. We traced 50 patients with PIBD receiving VDZ treatment at our hospital, reviewed their treatment protocol, trough levels, and antidrug antibodies, and compared those to fecal calprotectin (FC) levels and achievement of corticosteroid-free maintenance therapy (CF). VDZ trough level was available from 198 samples during a median follow- up of 12.6 months. Proceeding to maintenance therapy was associated with a decline in FC but not with VDZ trough levels that were comparable between patients with FC < 100 μg/g (remission), 100–1000 μg/g, or > 1000 μg/g at 3 months (mean levels of 36.8, 28.6, and 27 μg/mL, respectively p = 0.188). At 3 months, patients achieving CF (41%) and those on corticosteroids had comparable VDZ trough levels (33 vs. 27.5 μg/mL, respectively). At 6 months, the trough level was similar in groups with FC < 100 μg/g or FC > 1000 μg/g (31.5 and 27.6 μg/mL, p = 0.859). Treatment intensification did not improve the achieved CF at 12 months. None developed drug antibodies nor discontinued the therapy for an adverse event. Conclusion: VDZ was a well-tolerated and safe biologic treatment. A positive response on gut inflammation after induction predicted proceeding to maintenance therapy whereas trough levels did not. A VDZ trough level associated with clinical remission or continuing with VDZ treatment could not be determined.

What is Known:• In pediatric inflammatory bowel disease, vedolizumab is still in off-label use.• The results on the relationship between drug levels of vedolizumab and clinical remission in pediatric patients are contradictory.

What is New:• This real-life setting in pediatric-onset inflammatory bowel disease showed no benefit of therapy enhancement during a median follow-up of one year.• Trough levels of vedolizumab were not associated with therapy outcomes.
Intraoperative distensibility measurement in POEM for achalasia: impact on patient outcome and associations with other outcome variables at 1-year follow-up
Authors: Evensen Helge , Sandstad Olav , Larssen Lene , Hagen Milada , Kristensen Vendel A. , Søvik Torgeir Thorson , Schulz Anselm , Hauge Truls , Medhus Asle W. 
Published: October 2023

Abstract
Background and aims
The functional luminal imaging probe (FLIP) can provide measurements of lower esophageal sphincter (LES) distensibility. Studies report that use of intraoperative FLIP examination during peroral endoscopic myotomy (POEM) for achalasia is associated with treatment success, but evidence is limited and inconsistent. The main aim of the present study was to assess associations between intraoperative FLIP values and 1-year outcomes. Additionally, associations between 1-year FLIP measurements and other 1-year outcome variables were studied.

Methods
We performed a single-center prospective study of consecutive achalasia patients treated with POEM with a standardized 1-year follow-up. The inclusion period was from June 2017 to January 2020. We compared 1-year outcomes (FLIP measurement values, Eckardt score (ES), reflux esophagitis, timed barium esophagogram (TBE), and lower esophageal sphincter resting pressure (LES-rp)) in patients with and without intraoperative FLIP examination. We also assessed associations between intraoperative FLIP values, 1-year FLIP values, and other 1-year outcomes. Results are given as median (IQR), and non-parametrical statistical analyses were applied.

Results
Sixty-two patients (27 females) with median age 45 years (35–54) were included. Baseline characteristics were similar in patients with (n = 32) and without (n = 30) intraoperative FLIP examination. In patients with intraoperative FLIP, ES was 2 (1–3) and LES distensibility index (DI) 3.7 (2.6–5.4) after 1 year, compared with ES 2 (1–3) and DI 4.0 (3.1–6.8)) in patients without intraoperative FLIP (ns). Intraoperative DI was not correlated with 1-year ES or DI. One-year DI correlated significantly with 1-year ES (rs − 0.42), TBE (rs − 0.34), and LES-rp (rs − 0.29).

Conclusions
Use of intraoperative FLIP measurements in POEM for achalasia is not associated with improved 1-year outcome, and the clinical value of intraoperative FLIP in POEM for achalasia is questioned. Follow-up FLIP measurements are moderately associated with symptomatic outcome, and may serve as an additional diagnostic modality in post-treatment evaluation.

Graphical abstract
An adaptive model order reduction technique for parameter-dependent modular structures
Authors: Ritzert Stephan , Macek Domen , Simon Jaan-Willem , Reese Stefanie 
Published: October 2023

AbstractThis work is concerned with an adaptive reduced order model of modular structures assembled from parameter-dependent substructures. The substructures are reduced by proper orthogonal decomposition (POD) and connected by means of a tied contact formulation. We present a method to adapt the matrices of the substructures to parameter changes. We employ interpolation on Grassmann manifolds for the parametric adaption of the projection matrices. For the adaptation of the stiffness matrices, we use the direct empirical interpolation method (DEIM). Manifold interpolation of the reduced stiffness matrices, cannot be applied here since it would require semi-positive definiteness, which is here not fulfilled because of necessary rigid body motion modes. The novelty of this work is the application of these interpolation methods to the special problem class of POD-based tied contact model order reduction. Furthermore, we show a methodology to compute significant snapshots on the substructure level to compute a POD basis that can be used in different global structures.
Advances in pediatric acute kidney injury pharmacology and nutrition: a report from the 26th Acute Disease Quality Initiative (ADQI) consensus conference
Authors: Wong Vega Molly , Starr Michelle C. , Brophy Patrick D. , Devarajan Prasad , Soranno Danielle E. , Akcan-Arikan Ayse , Basu Rajit , Goldstein Stuart L. , Charlton Jennifer R. , Barreto Erin ,   the ADQI 26 workgroup
Published: October 2023

Abstract
Background
In the past decade, there have been substantial advances in our understanding of pediatric AKI. Despite this progress, large gaps remain in our understanding of pharmacology and nutritional therapy in pediatric AKI.

Methods
During the 26th Acute Disease Quality Initiative (ADQI) Consensus Conference, a multidisciplinary group of experts reviewed the evidence and used a modified Delphi process to achieve consensus on recommendations for gaps and advances in care for pharmacologic and nutritional management of pediatric AKI. The current evidence as well as gaps and opportunities were discussed, and recommendations were summarized.

Results
Two consensus statements were developed. (1) High-value, kidney-eliminated medications should be selected for a detailed characterization of their pharmacokinetics, pharmacodynamics, and pharmaco-“omics” in sick children across the developmental continuum. This will allow for the optimization of real-time modeling with the goal of improving patient care. Nephrotoxin stewardship will be identified as an organizational priority and supported with necessary resources and infrastructure. (2) Patient-centered outcomes (functional status, quality of life, and optimal growth and development) must drive targeted nutritional interventions to optimize short- and long-term nutrition. Measures of acute and chronic changes of anthropometrics, body composition, physical function, and metabolic control should be incorporated into nutritional assessments.

Conclusions
Neonates and children have unique metabolic and growth parameters compared to adult patients. Strategic investments in multidisciplinary translational research efforts are required to fill the knowledge gaps in nutritional requirements and pharmacological best practices for children with or at risk for AKI.
Effect of Carbon on the Melting Behavior of a Mold Powder under High Heating Rates
Authors: Gruber Nathalie 
Published: October 2023

AbstractMold powders used for the continuous casting of steels contain different carbon carriers controlling the melting behavior. During melting, carbon particles may accumulate at the liquid slag pool surface resulting in steel recarburization, which significantly changes the product quality. Thus, to reduce or prevent this reaction, mold powders with considerably reduced carbon content, or even without free carbon, are required. To replace carbon with another melting-controlling component, the effect on the melting behavior of mold powders under near-process conditions, such as high heating rates, should be investigated. Consequently, a different procedure was developed to evaluate the effect of various carbon contents on the melting behavior. In this contribution, a granulated ultra-low carbon (ULC) mold powder was selected, and different graphite contents (0, 1, 2, and 5%) were added. Furthermore, a sample obtained by granule disintegration and 5% graphite addition was produced and compared with a powdery sample. Subsequently, the steel crucibles were covered to reduce oxygen supply, filled with the samples, inserted into a preheated furnace (700–1300 °C), held at the selected temperatures for 10 min, and quenched to room temperature. The samples were mineralogically investigated, and the experimental method was applicable for characterizing the melting behavior of mold powders. At lower temperatures, carbon reduces the reactions between raw material components owing to reduced particle contact and prevents the formation of new solid (for example, cuspidine) and liquid phases. With increasing carbon content, the reactions shifted to higher temperatures, further delaying liquid phase formation. This effect was more evident for the powdery mold powder than for the granulated mold powders. At elevated temperatures, the powdery sample contained a coherent liquid phase, whereas the granules melted independently. This contribution provides a foundation for alternative melting-controlled additives for mold powders. It demonstrates that carbon substitutes should delay the reaction between raw material components and be stable until high temperatures.
Partial discharge diagnostics on inverter-fed drives of electric vehicles
Authors: Zajadatz Maurizio , Wöhr Erik , Suriyah Michael , Leibfried Thomas 
Published: October 2023

AbstractIn this paper, the possibilities of partial discharge measurement at square-wave voltages are discussed. The focus is on low-voltage machines, such as those used in electric vehicles. An insight into common measurement methods is given. In this work, high-frequency current transformers and near-field probes are used as sensors. The generation of a realistic steep-edged test voltage according to IEC/TS 61934 is also discussed and demonstrated on an inverter with silicon carbide semiconductors.Experiments are conducted to compare the sensors used. A direct comparison between cable-based sensors (HFCT) and antennas (near-field probes) is provided. Resonance points to open motor windings according to IEC/TS 60034-27‑5 and their significance for partial discharge measurement are also investigated. The results show that the high-frequency current transformers and the ball probe are able to detect PD even at steep voltage edges. Excitation with a fast voltage edge results in non-negligible overshoots in the overall system due to resonances. It can be shown that the partial discharges occur during these overvoltages.
Work loss and activity impairment due to extended nausea and vomiting in patients with breast cancer receiving CINV prophylaxis
Authors: Schwartzberg Lee , Navari Rudolph M. , Ruddy Kathryn J. , LeBlanc Thomas W. , Clark-Snow Rebecca , Wickham Rita , Kloth Dwight , Binder Gary , Bailey William L. , Turini Marco , Potluri Ravi , Liu Xing , Papademetriou Eros , Roeland Eric J. 
Published: October 2023

Abstract
Purpose
Chemotherapy-induced nausea and vomiting (CINV)’s impact on work loss remains poorly described. We evaluated associations between the duration of CINV episodes, CINV-related work loss (CINV-WL), and CINV-related activity impairment (CINV-AI) in patients with breast cancer receiving highly emetogenic chemotherapy.

Methods
We analyzed data from a prospective CINV prophylaxis trial of netupitant/palonestron and dexamethasone for patients receiving an anthracycline and cyclophosphamide (AC) for breast cancer (NCT0340371). Over the observed CINV duration (0–5 days), we analyzed patient-reported CINV-WL and CINV-AI for the first two chemotherapy cycles. We categorized patients as having either extended (≥ 3 days) or short (1–2 days) CINV duration and quantified its impact on work using the Work Productivity and Activity Impairment Questionnaire (WPAI).

Results
Overall, we captured data for 792 cycles in 402 women, including 136 (33.8%) employed patients with 35.3% reporting CINV. Of those with CINV, patients reported CINV-WL in 26 cycles and CINV-AI in 142 cycles. Of those with CINV, 55.3% of extended CINV cycles experienced CINV-WL compared to 16.7% of short CINV cycles (p < 0.001). The relative risk of CINV-WL between extended and short CINV was 3.32 (p < 0.01) for employed patients. The mean difference in CINV-AI scores (higher = worse) between extended and short duration CINV was 5.0 vs. 3.0 (p < 0.001).

Conclusion
Extended (≥ 3 days) CINV was associated with more than triple the risk of CINV-WL and higher CINV-AI compared with short CINV.
Zebra dolomites of the Spessart, Germany: implications for hydrothermal systems of the European Zechstein Basin
Authors: Kelka Ulrich , Beaudoin Nicolas E. , Lorenz Joachim , Koehn Daniel , Regenauer-Lieb Klaus , Boyce Adrian , Chung Peter 
Published: October 2023

AbstractZebra dolomites have a distinctive texture and are a peculiar structural variety of dolostones often encountered in the vicinity of base metal deposits commonly in the Mississippi Valley-Type (MVT). We investigate origin and evolution of the zebra dolomites found in the region of the Spessart, northwestern Bavaria, Germany, through diagenetic and petrogenetic analysis using SEM, CL microscopy, O–C isotopes, and fluid inclusion micro-thermometry. Here, we aim to shed light on the nature of the fluids that altered the zebra dolomite of the Zechstein formation. We distinguish the geochemical signatures of two different fluid flow regimes post-dating texture formation, each characterized by specific homogenization temperatures and oxygen–carbon isotope ratios (Event 1: Th = 120 °C; δ18Ofluids = [0 to 2‰]; Event 2; Th = 300 °C; δ18Ofluids = 18‰). Comparison of these fluids and the associated mineralization with published regional fluid flow data support that the zebra dolomites in the Spessart most likely coincided with the Permian large-scale fluid flow event that occurred throughout the European Zechstein Basin.
Graphical Abstract
Past and present risk of spring frosts for fruit trees in the Czech Republic
Authors: Zahradníček Pavel , Brázdil Rudolf , Řehoř Jan , Trnka Miroslav , Bartošová Lenka , Rožnovský Jaroslav 
Published: October 2023

AbstractRecent climate warming is reflected in the advanced onset of spring phenological phases of fruit trees and in so-called false springs. This then manifests as an increased risk of trees being damaged by late frosts in the sensitive growing stage. Based on the homogenised temperature series of 155 climatological stations divided into two altitudinal groups (below 300 m a.s.l. and 301–600 m a.s.l.), a climatological analysis of selected variables in relation to atmospheric circulation over the territory of the Czech Republic during the period 1961–2021 was performed. The number of frost days and the dates of their latest onset exhibited negative linear trends; however, only 16% and 20% were statistically significant. The onset of false spring (at least ten consecutive days with daily maximum ≥ 10 °C) was also characterised by decreasing trends, which significantly deepened after 1980. Spring frost days were particularly attributed to higher frequencies of anticyclonic circulation types such as the central anticyclone and circulation types with northeastern, eastern and southeastern airflow. False spring onset was particularly connected with the central anticyclone and circulation types with western and southwestern airflow. The increasing trends of frost risk days (days between the beginning of the false spring and the date of the latest frost with daily minimum < −1.5 °C) were statistically nonsignificant. Local series of fruit trees from southeastern Moravia proved to have significantly earlier onset of the first blossom and full blossoming phenophases. Although the damage by late frosts has been identified as an important factor contributing to low yields of fruit trees during the period 1996–2021 in the Czech Republic, other factors (e.g. other weather phenomena, diseases, pests, site, taking preventive measures against frost) must also be taken into account.
Forschung mit Krebsregistern – was geht, was (noch) nicht?
Authors: Katalinic Alexander , Pritzkuleit Ron , Kraywinkel Klaus 
Published: October 2023

Zusammenfassung
Hintergrund
Eine der Aufgaben der Landeskrebsregister ist die Bereitstellung von Daten für Forschung oder eigene Forschung. Daten werden im Krebsregister nicht primär für Forschung, sondern mit Meldepflicht und ohne Einwilligung der Betroffenen für die Erfüllung gesetzlicher Aufgaben erhoben. Sind Daten der Krebsregister für Forschung sinnvoll nutzbar, werden sie genutzt und welche Rahmenbedingungen zur Datennutzung sollten nachgebessert werden?

Methoden
Mittels PubMed®-Recherche wurde die Nutzung von Krebsregisterdaten in wissenschaftlichen Publikationen für Deutschland und für das US-SEER-Programm (Surveillance, Epidemiology, and End Results Program) ermittelt. Aus Landes- und Bundesgesetzen wurden Möglichkeiten zur Datennutzung ermittelt.

Ergebnisse
Für Deutschland wurden 2268 Artikel mit Krebsregisterdaten identifiziert, für 2022 etwa 250 Publikationen. Aus dem US-SEER-Programm gehen derzeit über 1500 Publikationen pro Jahr hervor. Aus den Krebsregistergesetzen wurden folgende wesentliche Nutzungsarten identifiziert: Bereitstellung und Nutzung von aggregierten und Einzelfalldaten, Kontaktierung von Krebserkrankten aus dem Registerbestand und Abgleich bestehender Kohorten mit dem Krebsregister. Während sich aggregierte und Einzelfalldaten i. d. R. mittels standardisierten Formulars beantragen lassen, erfordern die andern Nutzungsarten übliche wissenschaftliche Anträge mit Ethikvotum und ggf. weiteren Genehmigungen. Ausgewählte Praxisbeispiele zeigen die verschiedenen Nutzungsarten.

Schlussfolgerung
Die steigende Zahl an Publikationen belegt eine rege Forschungsnutzung. Dennoch ist in Deutschland das Potenzial nicht ausgereizt. Bundesländerübergreifende Projekte mit Verlinkung zu anderen Daten sind sehr aufwendig oder wegen bürokratischer Hürden oft nicht realistisch durchführbar. Mit Projekten und Gesetzesinitiativen wird derzeit versucht, solche Datennutzungen zu vereinfachen.
XLKarst, an Excel tool for time series analysis, spring recession curve analysis and classification of karst aquifers
Authors: Bailly-Comte V. , Ladouche B. , Charlier J. B. , Hakoun V. , Maréchal J. C. 
Published: October 2023

AbstractKarst aquifers are complex hydrogeological systems that require numerous in-situ measurements of hydrological and physico-chemical parameters to characterize transfer processes from the recharge area to the karst spring. Numerous graphical, statistical or signal processing methods have been developed for decades to interpret these measurements, but there is no simple and standardized tool that can be used for this purpose, which is necessary for a rigorous comparison of results between case studies. This Technical Note presents XLKarst, which has been developed to provide a simple and easy-to-use tool to process a selection of proven methods that characterize the functioning of karst systems. This tool allows (i) time series analysis based on correlation and spectral analysis and, for flow measurements, the use of other statistics and base flow separation, (ii) calculation of the cumulative distribution function to build a spring flow probability plot, and (iii) analysis of spring flow recession and expression of the results in a karst system classification scheme. These methods are first described by providing the key elements of their use and interpretation in the scientific literature. Then, an application to the Fontaine de Nîmes karst system (southern France) is used to highlight the complementarity of the methods proposed by XLKarst to describe the hydrodynamic behavior of a karst system based on daily data of rainfall and discharge over 22 years.