bluuebunny/crossref_metadata_2025_split huggingface dataset:
Epimorphic development in tropical shallow-water Nymphonidae (Arthropoda: Pycnogonida) revealed by fluorescence imaging
Authors: Arango Claudia P. , Brenneis Georg 
Published: January 2024

Abstract
Background
Extant lineages of sea spiders (Pycnogonida) exhibit different types of development. Most commonly, pycnogonids hatch as a minute, feeding protonymphon larva with subsequent anamorphic development. However, especially in cold water habitats at higher latitudes and in the deep sea, some taxa have large, lecithotrophic larvae, or even undergo extended embryonic development with significantly advanced postlarval hatching stages. Similar biogeographic trends are observed in other marine invertebrates, often referred to as “Thorson’s rule”.

Results
To expand our knowledge on the developmental diversity in the most speciose pycnogonid genus Nymphon, we studied the developmental stages of the two tropical representatives N. floridanum and N. micronesicum., We compared classical scanning electron microscopy with fluorescence-based approaches to determine which imaging strategy is better suited for the ethanol-fixed material available. Both species show epimorphic development and hatch as an advanced, lecithotrophic postlarval instar possessing the anlagen of all body segments. Leg pairs 1–3 show a considerable degree of differentiation at hatching, but their proximal regions remain coiled and hidden under the cuticle of the hatching instar. The adult palp and oviger are not anteceded by three-articled larval limbs, but differentiate directly from non-articulated limb buds during postembryonic development.

Conclusions
Fluorescence imaging yielded more reliable morphological data than classical scanning electron microscopy, being the method of choice for maximal information gain from rare and fragile sea spider samples fixed in high-percentage ethanol. The discovery of epimorphic development with lecithotrophic postlarval instars in two small Nymphon species from tropical shallow-water habitats challenges the notion that this developmental pathway represents an exclusive cold-water adaptation in Nymphonidae. Instead, close phylogenetic affinities to the likewise more direct-developing Callipallenidae hint at a common evolutionary origin of this trait in the clade Nymphonoidea (Callipallenidae + Nymphonidae). The lack of functional palpal and ovigeral larval limbs in callipallenids and postlarval hatchers among nymphonids may be a derived character of Nymphonoidea. To further test this hypothesis, a stable and well-resolved phylogenetic backbone for Nymphonoidea is key.
Elitist-opposition-based artificial electric field algorithm for higher-order neural network optimization and financial time series forecasting
Authors: Nayak Sarat Chandra , Dehuri Satchidananda , Cho Sung-Bae 
Published: January 2024

AbstractThis study attempts to accelerate the learning ability of an artificial electric field algorithm (AEFA) by attributing it with two mechanisms: elitism and opposition-based learning. Elitism advances the convergence of the AEFA towards global optima by retaining the fine-tuned solutions obtained thus far, and opposition-based learning helps enhance its exploration ability. The new version of the AEFA, called elitist opposition leaning-based AEFA (EOAEFA), retains the properties of the basic AEFA while taking advantage of both elitism and opposition-based learning. Hence, the improved version attempts to reach optimum solutions by enabling the diversification of solutions with guaranteed convergence. Higher-order neural networks (HONNs) have single-layer adjustable parameters, fast learning, a robust fault tolerance, and good approximation ability compared with multilayer neural networks. They consider a higher order of input signals, increased the dimensionality of inputs through functional expansion and could thus discriminate between them. However, determining the number of expansion units in HONNs along with their associated parameters (i.e., weight and threshold) is a bottleneck in the design of such networks. Here, we used EOAEFA to design two HONNs, namely, a pi-sigma neural network and a functional link artificial neural network, called EOAEFA-PSNN and EOAEFA-FLN, respectively, in a fully automated manner. The proposed models were evaluated on financial time-series datasets, focusing on predicting four closing prices, four exchange rates, and three energy prices. Experiments, comparative studies, and statistical tests were conducted to establish the efficacy of the proposed approach.
Sex disparities in physical activity domains and hypertension prevalence
Authors: Cho Min Jeong , Jung Yong Joon , Min Ho Jeong , Kim Hyun Jeong , Kunutsor Setor K. , Jae Sae Young 
Published: January 2024

Abstract
Background
This study aimed to examine the associations of leisure time physical activity (LTPA) and occupational physical activity (OPA) with the prevalence of hypertension, while exploring the sex disparities in these associations.

Methods
A cross-sectional study was conducted using data from the Korea National Health and Nutrition Examination Survey between 2014 and 2019 (n = 26,534). Hypertension was defined as the use of antihypertensive drugs or systolic and diastolic blood pressure ≥ 140/90 mm Hg. Self-reported physical activity (PA), assessed by the global PA questionnaire, was categorized into three domains: total PA, LTPA and OPA. Each PA domain was classified based on METs-min/wk and intensity.

Results
In a multivariable adjusted model, the odds ratio (OR) with 95% confidence intervals (CIs) for the prevalence of hypertension in the active versus inactive group, based on METs, was 0.92 (95% CI 0.85–0.99) for total PA, 0.90 (95% CI 0.83–0.98) for LTPA and 1.21 (95% CI 1.05–1.38) for OPA. Compared to the inactive group, moderate to vigorous intensity was associated with a lower odds of hypertension for total PA and LTPA (total PA: OR 0.95, 95% CI 0.89-1.00 and LTPA: OR 0.92, 95% CI 0.86–0.98), but a higher odd for OPA (OR 1.17, 95% CI 1.05–1.30). Subgroup analyses showed significant evidence of effect modification by sex on the associations of total PA and LTPA (METs and intensity) with hypertension prevalence (p-values for interaction < 0.01); the associations were generally stronger for women. OPA was associated with a higher prevalence of hypertension in women, but not in men (p-value for interaction > 0.05).

Conclusions
Higher levels of total PA and LTPA were associated with lower prevalence of hypertension in both men and women, with slightly stronger associations for women. However, higher OPA was associated with a higher prevalence of hypertension in women. These findings support the PA health paradox hypothesis and highlight the sex disparities in the association between OPA and hypertension prevalence.
Use of computed tomography coronary calcium score for prediction of cardiovascular events in cancer patients: a retrospective cohort analysis
Authors: Patel Sinal , Franco Francisco X. , McDonald Malcolm , Rivera Carlos , Perez-Villa Bernardo , Collier Patrick , Moudgil Rohit , Gupta Neha , Sadler Diego B. 
Published: January 2024

AbstractBackgroundCT- coronary calcium score, is one of the most studied and widely available modalities in cardiovascular medicine. Coronary artery calcium score (CACS) is an established predictor of coronary artery disease. The ‘standard of care’ diagnostic modality to measure CACS is ECG-gated Cardiac Multi-Detector Computed Tomography. There is convincing evidence of a strong association between CACS and major cardiovascular (CV) events in asymptomatic individuals. Cancer patients (C) may have a higher risk for CV disease than non-cancer patients (NC) related not only to cancer treatments but also to shared biological factors and pathways. Thus, identifying tools for early detection of CV disease in this population is of utmost importance.MethodsA retrospective cohort analysis was performed with patients from Cleveland Clinic Florida and Ohio who had CACS from 2017 to 2021. Patients who had cancer diagnosis prior to CACS were matched to NC for age and sex. CV events after their index CACS events were compared between C and NC, and matched control and propensity analysis were conducted.ResultsTen thousand seven hundred forty-two patients had CACS; 703 cancer patients had CACS and were eligible. Extensive CACS (> 400) were significantly higher in cancer, 94 (13.37%) vs non-cancer patients, 76 (10.83%),P = 0.011. Furthermore, after propensity matched analysis, CACS > 400 was 14.8% in C vs 9.6% in NC,P =  < 0.05. CV events were similar in both cohorts (p = NS), despite less CV risk factors in cancer patients (P =  < 0.05). For the combined moderate (101–400) & extensive (> 400) CACS, the prevalence of stroke and peripheral arterial disease, a marker of systemic atherosclerosis, was significantly higher in patients with cancer (P < 0.01).ConclusionsDespite having fewer CV risk factors in our study, similar CACS in cancer patients are suggestive of a higher prevalence of CV disease independent of traditional risk factors. High CACS and the overall prevalence of vascular events were more frequent in patients with cancer. Higher prevalence of peripheral arterial disease and cerebrovascular accident further suggests the increased atherosclerotic burden in C.
Investigating time to first birth among women of reproductive age in Bangladesh: a survival analysis of nationwide cross-sectional survey data
Authors: Sobhan Abdus , Moinuddin Mohammed , Hossain Md. Moyazzem 
Published: January 2024

AbstractBackgroundThe birth of the first child is an important turning point in a woman’s life as it is the starting point of the demanding responsibilities of motherhood and childcare. This study aimed to explore the waiting time and the significant indicators of time to the first birth of aged 15–49 years of ever-married women in Bangladesh.MethodsThe study considered the most recent country-representative data collected from Bangladesh Demographic and Health Survey (BDHS) in 2017/18. The log-rank test was used to assess the statistical significance of the observed difference between waiting time to first birth and various socio-economic and demographic factors. The Cox proportional hazard model is applied to identify the influential factors for waiting time to first birth.ResultsAbout 55% of the respondents’ age at their first birth was less than 18 years. More than 21% of them were 20 years and above at their first birth. Findings revealed a higher mean age at first birth in urban areas than in rural areas. Also, in Dhaka and Sylhet region, women have a higher age at first than in other regions of Bangladesh. Results show that the place of residence, region, age at first marriage, age at first sex, respondent’s education, employment status, contraceptive use, and mass media exposure were found to be statistically significant determinants of the age of respondents at the time of first birth. Findings also show that a woman from rural areas was likely to be 5% smaller in age at the time of first birth than their counterpart (aHR 1.05; 95% CI 1.01–1.10). The age at first birth of a woman in Chattogram was 24% shorter, while in Rangpur and Barishal, that age was increased by 14% and 8%, respectively. A woman with no education, primary, and secondary education had 28%, 38%, and 29%, respectively, shorter age at first birth than that of the higher educated women. Mass media unexposed women were shorter aged at first birth by 27% (aHR 1.27; 95% CI 1.10–1.47) compared to the women who were mass media exposed.ConclusionIt is necessary to increase the age of mothers at first birth which may help to reduce the prevalence of child marriage in Bangladesh. The study findings will be helpful to the policymakers in identifying the gap and designing the programmes targeting the early timing of first birth to reduce child mortality as well as poor maternal outcomes which will be beneficial for achieving the Sustainable Development Goal-3 in Bangladesh.
Network pharmacology to unveil the mechanism of suanzaoren decoction in the treatment of alzheimer’s with diabetes
Authors: Chen Tao , Lei Yining , Li Manqin , Liu Xinran , Zhang Lu , Cai Fei , Gong Xiaoming , Zhang Ruyi 
Published: January 2024

Abstract
Background
Suanzaoren Decoction (SZRD), a well-known formula from traditional Chinese medicine, has been shown to have reasonable cognitive effects while relaxing and alleviating insomnia. Several studies have demonstrated significant therapeutic effects of SZRD on diabetes and Alzheimer’s disease (AD). However, the active ingredients and probable processes of SZRD in treating Alzheimer’s with diabetes are unknown. This study aims to preliminarily elucidate the potential mechanisms and potential active ingredients of SZRD in the treatment of Alzheimer’s with diabetes.

Methods
The main components and corresponding protein targets of SZRD were searched on the TCMSP database. Differential gene expression analysis for diabetes and Alzheimer’s disease was conducted using the Gene Expression Omnibus database, with supplementation from OMIM and genecards databases for differentially expressed genes. The drug-compound-target-disease network was constructed using Cytoscape 3.8.0. Disease and SZRD targets were imported into the STRING database to construct a protein-protein interaction network. Further, Gene Ontology and Kyoto Encyclopedia of Genes and Genomes analyses were performed on the intersection of genes. Molecular docking and molecular dynamics simulations were conducted on the Hub gene and active compounds. Gene Set Enrichment Analysis was performed to further analyze key genes.

Results
Through the Gene Expression Omnibus database, we obtained 1977 diabetes related genes and 622 AD related genes. Among drugs, diabetes and AD, 97 genes were identified. The drug-compound-target-disease network revealed that quercetin, kaempferol, licochalcone a, isorhamnetin, formononetin, and naringenin may be the core components exerting effects. PPI network analysis identified hub genes such as IL6, TNF, IL1B, CXCL8, IL10, CCL2, ICAM1, STAT3, and IL4. Gene Ontology and Kyoto Encyclopedia of Genes and Genomes analyses showed that SZRD in the treatment of Alzheimer’s with diabetes is mainly involved in biological processes such as response to drug, aging, response to xenobiotic, and enzyme binding; as well as signaling pathways such as Pathways in cancer, Chemical carcinogenesis - receptor activation, and Fluid shear stress and atherosclerosis. Molecular docking results showed that licochalcone a, isorhamnetin, kaempferol, quercetin, and formononetin have high affinity with CXCL8, IL1B, and CCL2. Molecular dynamics simulations also confirmed a strong interaction between CXCL8 and licochalcone a, isorhamnetin, and kaempferol. Gene Set Enrichment Analysis revealed that CXCL8, IL1B, and CCL2 have significant potential in diabetes.

Conclusion
This study provides, for the first time, insights into the active ingredients and potential molecular mechanisms of SZRD in the treatment of Alzheimer’s with diabetes, laying a theoretical foundation for future basic research.

Graphical Abstract
Leadership of school principals for school health implementation among primary schools in Mataram, Indonesia: a qualitative study
Authors: Sasaki Hirono , Sari Dian Puspita , Warnaini Cut , Andiwijaya Fahrin Ramadan , Takeuchi Rie , Kadriyan Hamsu , Shibuya Fumiko , Kobayashi Jun 
Published: January 2024

Abstract
Background
Health-promoting schools (HPS) are acknowledged as a comprehensive approach to improving children’s health and educational outcomes through learning and school life. Principals are key players in HPS implementation. However, concrete leadership practices in HPS in low- to middle-income countries have not been clarified. Therefore, this study aimed to explore and generate themes surrounding the leadership practices of principals in implementation of school health in Indonesia, a predominantly Muslim country consisting of diverse religions that have expanded HPS at the national level.

Methods
In-depth interviews and focus group discussions (FGDs) were conducted with the principals, teachers, parent representatives, and school board committee members in 10 target schools. FGDs were conducted with school health supervisory board members in Mataram City. All interviews were recorded and transcribed. Thematic analysis was undertaken to generate themes.

Results
The principals demonstrated leadership practices based on their religious beliefs, values, and morals. This may suggest that beliefs and morals support an understanding of their responsibility to ensure the well-being of all school community members, regardless of religion, in a diverse environment that is predominantly Muslim but also multicultural and multi-religious. Further, these beliefs and morals might reinforce implementation of school health. Importantly, the principals’ coordination skills in cooperating with multiple sectors might contribute to successful implementation of school health. Also, principals emphasized they were tasked to develop capacity for implementation of school health. Thus, principals should understand leadership in the implementation of school health as their duty from the training stage to encourage health at the school level.

Conclusion
In this study, “have professional educators’ beliefs and religious beliefs and Indonesia’s morals” was generated as a new theme, whereas several common themes were found as in previous studies. The results of this study suggested the importance of leadership by principals in the implementation of school health. Strengthening the capacity of school principals by integrating the contents of school health leadership practice into pre- and in-service training through the development of a policy on principals’ duties in school health might contribute to the successful implementation of school health.
Impact of El Niño on public health and its preparedness measures
Authors: Rony Moustaq Karim Khan , Wahiduzzaman Md. , Rahman Muhammad Mostafijur , Bala Shuvashish Das 
Published: January 2024

Abstract
Background
El Niño events disrupt atmospheric and oceanic interactions, leading to shifts in precipitation, temperature, and extreme weather events. Such alterations have the potential to exacerbate heatwaves, increase vector-borne and waterborne diseases, and compromise air quality. Understanding the connection between El Niño and public health vulnerabilities is crucial for effective mitigation and preparedness.

Main body of the abstract
This article aimed to investigate the impact of El Niño on public health and its preparedness measures. A comprehensive literature review was conducted, involving systematic searches across academic databases, scientific journals, and relevant grey literature. Inclusion criteria encompassed studies that explored the link between El Niño and public health outcomes, as well as strategies for enhancing preparedness. Thematic analysis was employed to synthesize findings and identify key themes. This article revealed that El Niño events contribute to a spectrum of public health challenges, including heat-related illnesses and compromised air quality. Vulnerable populations, such as the elderly, children, and those with pre-existing medical conditions, are particularly at risk. Early warning systems, health infrastructure readiness, communication strategies, and collaborative efforts emerged as vital preparedness measures.

Short conclusion
El Niño’s impact on public health and preparedness measures is a complex and multifaceted issue that requires a unified and proactive approach. By understanding the interplay between El Niño events and health vulnerabilities, communities can better prepare for and mitigate the health risks posed by these climatic fluctuations. Strengthened early warning systems, improved healthcare infrastructure, effective communication strategies, and collaborative efforts between various stakeholders are crucial in enhancing preparedness and safeguarding public health in the face of El Niño’s capricious influence.
Hydrothermal synthesis of zeolites from residual waste generated via indirect carbonation of coal fly ash
Authors: Shin Seonmi , Kim Myoung-Jin 
Published: January 2024

AbstractIndirect carbonation, a technology to store CO2 and produce stable CaCO3 and MgCO3, involves elution of Ca and Mg from industrial waste and subsequent carbonation. Although substantial residual waste is generated after the elution of Ca and Mg, its recycling attributes have not been adequately scrutinized. The residual waste has lower Ca and Mg contents and higher Si and Al contents than those of the raw material (i.e., industrial waste). This study involves the hydrothermal synthesis of zeolite-P using residual waste from indirect carbonation, conducted at both 100 and 180 ℃. The properties of these zeolites are compared with those synthesized from coal fly ash (CFA). The synthesized zeolites were characterized by X-ray diffraction, field emission scanning electron microscope, thermogravimetric analyzer, and Brunauer–Emmett–Teller (BET). A high zeolite conversion efficiency was achieved through a hydrothermal reaction (up to 87%), even though Si and Al were not added to the residual waste. Additionally, the cation exchange capacity and BET specific surface area of the synthesized zeolites were high (200 cmol kg−1 and 73 m2 g−1, respectively). These findings highlight the possibility of synthesizing zeolites using the residual waste from indirect carbonation as an alternative to conventional zeolite synthesis using industrial waste such as CFA. The synthesized zeolite-P is expected to be effective in wastewater treatment, detergent manufacturing, and water softening.
Diffusion tensor imaging of brain changes in patients with chronic kidney disease before cognitive impairment with 3 T MRI device
Authors: Moustafa Sherif Abdel Fattah , Rizk Dina Abd Elnasser , El Serougy Lamiaa Galal , El Said El Azab Mohamed , Mustafa Wessam 
Published: January 2024

Abstract
Background
Patients with chronic kidney disease (CKD) are at risk of a many of central nervous system complications such as stroke and cognitive impairment. Studies based on diffusion tensor imaging (DTI) confirmed that the integrity of white matter in CKD patients has changed and these alterations can be observed before tissue morphological changes occurring on conventional MRI. Early use of DTI in CKD patients can distinguish early individuals with normal cognitive system function and will develop cognitive impairment in later stages.

Results
As compared with controls, patients with CKD showed increased MD and decreased FA values in different brain regions with frontal, parietal regions and genu of corpus callosum more affected more than the occipital regions. For combined FA and MD in differentiating cases with CKD, there was statistically significant difference in both thalami, internal capsule, CC, cingulum, ILF and CST as p value < 0.05.

Conclusions
DTI with fiber tractography can present the mainstay of imaging in evaluating the white matter integrity in CKD patient has normal conventional MRI with better diagnostic accuracy in differentiation between healthy and altered white matters.