bluuebunny/crossref_metadata_2025_split huggingface dataset:
Characterizing the Impacts of Multi‐Scale Heterogeneity on Solute Transport in Fracture Networks
Authors: Sweeney Matthew R. , Hyman Jeffrey D. , O’Malley Daniel , Santos Javier E. , Carey J. William , Stauffer Philip H. , Viswanathan Hari S. 
Published: October 2023

AbstractWe model flow and transport in fracture networks with varying degrees of fracture‐to‐fracture aperture heterogeneity and network intensity to show how changes in these properties can cause the emergence of anomalous flow and transport behavior. If fracture‐to‐fracture aperture heterogeneity is increased in sparse networks, velocity fluctuations inhibit high flow rates and solute transport can be delayed. Surprisingly, transport can be slowed even in cases where hydraulic aperture is monotonically increased. As the intensity of the networks is increased, more connected pathways allow for particles to bypass these effects. There exists transition behavior where with relatively few connected pathways in a network, first arrival times of particles are not heavily affected by fracture‐to‐fracture aperture heterogeneity, but the scaling behavior of the tails is strongly influenced. These results reinforce the importance of considering multi‐scale effects in fractured systems and can inform flow and transport processes in both natural and engineered fractured systems.
Exposure to perfluoroalkyl and polyfluoroalkyl substances and pediatric obesity: a systematic review and meta-analysis
Authors: Frangione Brianna , Birk Sapriya , Benzouak Tarek , Rodriguez-Villamizar Laura A. , Karim Fatima , Dugandzic Rose , Villeneuve Paul J. 
Published: October 2023

Abstract
Introduction
Perfluoroalkyl and polyfluoroalkyl substances (PFAS) are potentially obesogenic for children. We undertook a systematic review to synthesize this literature and explore sources of heterogeneity in previously published epidemiological studies.

Methods
Studies that collected individual-level PFAS and anthropometric data from children up to 12 years of age were identified by searching six databases. We excluded studies that only evaluated obesity measures at the time of birth. A full-text review and quality assessment of the studies was performed using the Office of Health Assessment and Translation (OHAT) criteria. Forest plots were created to summarize measures of association and assess heterogeneity across studies by chemical type and exposure timing. Funnel plots were used to assess small-study effects.

Results
We identified 24 studies, of which 19 used a cohort design. There were 13 studies included in the meta-analysis examining various chemicals and outcomes. Overall prenatal exposures to four different types of PFAS were not statistically associated with changes in body mass index (BMI) or waist circumference. In contrast, for three chemicals, postnatal exposures were inversely related to changes in BMI (i.e., per log10 increase in PFOS: BMI z-score of −0.16 (95% CI: −0.22, −0.10)). There was no substantial heterogeneity in the reported measures of association within prenatal and postnatal subgroups. We observed modest small-study effects, but correction for these effects using the Trim and Fill method did not change our summary estimate(s).

Conclusion
Our review found no evidence of a positive association between prenatal PFAS exposure and pediatric obesity, whereas an inverse association was found for postnatal exposure. These findings should be interpreted cautiously due to the small number of studies. Future research that can inform on the effects of exposure mixtures, the timing of the exposure, outcome measures, and the shape of the exposure-response curve is needed.
Epigenome-wide association study of peripheral immune cell populations in Parkinson’s disease
Authors: Andersen Maren Stolp , Leikfoss Ingvild Sørum , Brorson Ina Skaara , Cappelletti Chiara , Bettencourt Conceicao , Toft Mathias , Pihlstrøm Lasse 
Published: October 2023

AbstractUnderstanding the contribution of immune mechanisms to Parkinson’s disease pathogenesis is an important challenge, potentially of major therapeutic implications. To further elucidate the involvement of peripheral immune cells, we studied epigenome-wide DNA methylation in isolated populations of CD14+ monocytes, CD19+ B cells, CD4+ T cells, and CD8+ T cells from Parkinson’s disease patients and healthy control participants. We included 25 patients with a maximum five years of disease duration and 25 controls, and isolated four immune cell populations from each fresh blood sample. Epigenome-wide DNA methylation profiles were generated from 186 samples using the Illumina MethylationEpic array and association with disease status was tested using linear regression models. We identified six differentially methylated CpGs in CD14+ monocytes and one in CD8 + T cells. Four differentially methylated regions were identified in monocytes, including a region upstream of RAB32, a gene that has been linked to LRRK2. Methylation upstream of RAB32 correlated negatively with mRNA expression, and RAB32 expression was upregulated in Parkinson’s disease both in our samples and in summary statistics from a previous study. Our epigenome-wide association study of early Parkinson’s disease provides evidence for methylation changes across different peripheral immune cell types, highlighting monocytes and the RAB32 locus. The findings were predominantly cell-type-specific, demonstrating the value of isolating purified cell populations for genomic studies.
A cost effective communication model for requirements elicitation in global software development
Authors: Rauf Muhammad Aqib , Bibi Sarfraz , Ali Sadia , AlSaedi Tahani , Ur Rehman Saif , Mahmood Khalid , Kundi Mahwish 
Published: October 2023

AbstractRequirement elicitation stands as a pivotal activity within requirement engineering, gaining even greater significance in the context of global software development. Effective communication among stakeholders assumes paramount importance in this arena. Factors such as time zone disparities, cultural variations, and language differences exert a formidable impact on communication within the sphere of global software development. These dynamics inevitably impinge upon timely coordination, potentially compromising the software's quality. In response, researchers have proffered communication models tailored for requirement elicitation within the ambit of global software development. The purpose of this study is to conduct an in-depth critical review of existing communication models for demand elicitation in global software development. Through this comprehensive review, we aim to discern prevailing publication trends, provide an introductory overview, and illuminate the strengths and limitations inherent in the existing communication models. By identifying these limitations, we seek to advance a novel, low-cost communication approach designed primarily for demand elicitation in global software development. To culminate our endeavor, we will undertake a case study-based experiment, meticulously designed to assess the efficacy and practical utility of the proposed techniques.
Topology of turbulence within collisionless plasma reconnection
Authors: Hnat Bogdan , Chapman Sandra , Watkins Nicholas 
Published: October 2023

AbstractIn near-collisionless plasmas, which are ubiquitous in astrophysics, entropy production relies on fully-nonlinear processes such as turbulence and reconnection, which lead to particle acceleration. Mechanisms for turbulent reconnection include multiple magnetic flux ropes interacting to generate thin current sheets which undergo reconnection, leading to mixing and magnetic merging and growth of coherent structures, unstable reconnection current layers that fragment and turbulent reconnection outflows. All of these processes act across, and encompass, multiple reconnection sites. We use Magnetospheric Multi Scale four-point satellite observations to characterize the magnetic field line topology within a single reconnection current layer. We examine magnetopause reconnection where the spacecraft encounter the Electron Diffusion Region (EDR). We find fluctuating magnetic field with topology identical to that found for dynamically evolving vortices in hydrodynamic turbulence. The turbulence is supported by an electron-magnetohydrodynamic (EMHD) flow in which the magnetic field is effectively frozen into the electron fluid. Accelerated electrons are found in the EDR edge where we identify a departure from this turbulent topology, towards two-dimensional sheet-like structures. This is consistent with a scenario in which sub-ion scale turbulence can suppress electron acceleration within the EDR which would otherwise be possible in the electric field at the X-line.
Poor sleep quality, COPD severity and survival according to CASIS and Pittsburgh questionnaires
Authors: Sampol Júlia , Miravitlles Marc , Sáez María , Pallero Mercedes , Sampol Gabriel , Ferrer Jaume 
Published: October 2023

AbstractPoor sleep quality is frequent among COPD patients and it has been related to worse outcomes. The objective of this study was to compare the COPD and Asthma Sleep Impact Scale (CASIS) and the generic Pittsburgh Sleep Quality Index (PSQI) questionnaires as reliable tools for evaluating sleep quality and its relationship with COPD characteristics and survival. Stable COPD patients were prospectively evaluated. Anthropometric, sociodemographic, comorbidity, lung function and treatment data were collected. All patients completed CASIS and PSQI, mMRC dyspnea severity scale, COPD Assessment Test (CAT), sleep apnoea STOP-Bang and Hospital Anxiety and Depression Scale (HADS) questionnaires. Body mass index, airflow Obstruction, Dyspnea and Exacerbations (BODEx) index was calculated. Life status was determined after a mean follow-up of 3.7 (SD 1) years. We included 200 patients, 69.5% male, mean age 65.8 (9) years. Poor sleep was detected in 100 (50%) and 84 patients (42%) according to PSQI and CASIS questionnaires, respectively, with an agreement of 63%. Poor sleep was related to female gender, more severe dyspnea and worse BODEx, HADS and CAT scores according to both questionnaires. PSQI was associated to chronic pain or inferior urinary tract symptoms and CASIS to exacerbations, shorter walked distance in the 6-min walking test and treatment with oral corticosteroids or chronic oxygen. Thirty nine (19.5%) patients died during follow-up. Mortality was not associated to PSQI nor CASIS results. Unlike PSQI, CASIS is more related to COPD severity and its results are not influenced by comorbidities with known impact on sleep quality. In our sample, poor sleep quality was not associated with increased mortality.
Machine learning based readmission and mortality prediction in heart failure patients
Authors: Sabouri Maziar , Rajabi Ahmad Bitarafan , Hajianfar Ghasem , Gharibi Omid , Mohebi Mobin , Avval Atlas Haddadi , Naderi Nasim , Shiri Isaac 
Published: October 2023

AbstractThis study intends to predict in-hospital and 6-month mortality, as well as 30-day and 90-day hospital readmission, using Machine Learning (ML) approach via conventional features. A total of 737 patients remained after applying the exclusion criteria to 1101 heart failure patients. Thirty-four conventional features were collected for each patient. First, the data were divided into train and test cohorts with a 70–30% ratio. Then train data were normalized using the Z-score method, and its mean and standard deviation were applied to the test data. Subsequently, Boruta, RFE, and MRMR feature selection methods were utilized to select more important features in the training set. In the next step, eight ML approaches were used for modeling. Next, hyperparameters were optimized using tenfold cross-validation and grid search in the train dataset. All model development steps (normalization, feature selection, and hyperparameter optimization) were performed on a train set without touching the hold-out test set. Then, bootstrapping was done 1000 times on the hold-out test data. Finally, the obtained results were evaluated using four metrics: area under the ROC curve (AUC), accuracy (ACC), specificity (SPE), and sensitivity (SEN). The RFE-LR (AUC: 0.91, ACC: 0.84, SPE: 0.84, SEN: 0.83) and Boruta-LR (AUC: 0.90, ACC: 0.85, SPE: 0.85, SEN: 0.83) models generated the best results in terms of in-hospital mortality. In terms of 30-day rehospitalization, Boruta-SVM (AUC: 0.73, ACC: 0.81, SPE: 0.85, SEN: 0.50) and MRMR-LR (AUC: 0.71, ACC: 0.68, SPE: 0.69, SEN: 0.63) models performed the best. The best model for 3-month rehospitalization was MRMR-KNN (AUC: 0.60, ACC: 0.63, SPE: 0.66, SEN: 0.53) and regarding 6-month mortality, the MRMR-LR (AUC: 0.61, ACC: 0.63, SPE: 0.44, SEN: 0.66) and MRMR-NB (AUC: 0.59, ACC: 0.61, SPE: 0.48, SEN: 0.63) models outperformed the others. Reliable models were developed in 30-day rehospitalization and in-hospital mortality using conventional features and ML techniques. Such models can effectively personalize treatment, decision-making, and wiser budget allocation. Obtained results in 3-month rehospitalization and 6-month mortality endpoints were not astonishing and further experiments with additional information are needed to fetch promising results in these endpoints.
Safety and tolerability of long-term apomorphine infusion in advanced Parkinson's disease: an Indian multi-center (APO-IND) experience
Authors: Metta Vinod , Dhamija Rajinder K. , Batzu Lucia , Mrudula Rukmini , Kumar Natuva Sai Sampath , S. Arunan , Falup-Pecurariu Cristian , Rodriguez-Blazquez Carmen , Goyal Vinay , L.K. Prashanth , Bhattacharya Kalyan , Kumar Suresh , Chaudhuri Kallol Ray , Borgohain Rupam 
Published: October 2023

AbstractAdvanced Parkinson’s Disease (APD) is complicated by the emergence of motor and non-motor fluctuations, which are initially predictable and eventually become unpredictable, in part due to erratic gastric absorption and short half of oral levodopa. Attempts to manage such fluctuations with oral dopaminergic drugs often lead to disabling dyskinesias. Continuous Subcutaneous Apomorphine Infusion (CSAI), despite being approved for the treatment of APD since 1993, was approved in India only in 2019. We studied the safety, tolerability and efficacy of CSAI in Indian patients with APD in a registry design to raise local awareness of this important treatment. We conducted a prospective registry-based observational audit at 10 centers across different states of India. Patients with APD, not responding to or with significant side effects from oral dopaminergic therapy, were assessed at baseline and at month 6 and 12 following CSAI infusion. Fifty-one patients completed the study, CSAI significantly reduced the functional impact of dyskinesia (p < 0.01 at 6 months and p < 0.001 at 12 months). There was a significant improvement in the OFF-state from baseline (p < 0.01 at 6 months and p < 0.001 at 12 months) No discernible side effects were observed apart from mild site reaction (n = 7), nausea (n = 7) skin nodules (n = 2). CSAI demonstrated safety, efficacy, tolerability and improved quality of life in patients with APD, as shown in previous studies. Our study highlighted current existing inequalities in treatment availability, lack of awareness, knowledge gap, affordability and cost remains a concern regarding apomorphine use in Indian PD population.
Tracing the Galactic disk with planetary nebulae using Gaia DR3
Authors: Bucciarelli B. , Stanghellini L. 
Published: October 2023

Aims. We study the population of Galactic planetary nebulae (PNe) and their central stars (CSPNe) through the analysis of their distances and Galactic distribution. The PN distances are obtained by means of a revised statistical distance scale, based on an astrometrically-defined sample of their central stars from the third Gaia Data Release (DR3) as calibrators. The new statistical distances, together with the proper motion of the CSPNe (also from DR3) with published PN abundances as well as radial velocities, are used to characterize the PN populations in the Galaxy and to derive the radial metallicity gradient.
Methods. The statistical scale was applied to infer the distances of a significant number (∼850) of Galactic PNe, for which we deliver a new catalog of PN distances. By adopting a circular velocity curve of the Galaxy, we also obtained peculiar 3D velocities for a large sample of PNe (∼300). The elemental abundances of the PNe were culled from the literature for an updated catalog, to be used in our analysis and other external applications.
Results. The radial chemical gradient of the Galactic disk is traced by PNe with available chemical abundances and distances, and kinematic data of the CSPNe are employed to identify the halo PN population. We date PN progenitors based both on abundances and kinematic properties, finding a confirmation of the first method with the second. For all PNe with at least one oxygen determination in the literature, we find a slope of the radial oxygen gradient equal to Δ log(O/H)/ΔRG = −0.0144 ± 0.00385 [dex kpc−1]. Furthermore, we estimate radial oxygen gradients for the PNe with old (> 7.5 Gyr) and young (< 1 Gyr) progenitors to be Δ log(O/H)/ΔRG = −0.0121 ± 0.00465 and −0.022 ± 0.00758 [dex kpc−1], respectively, thus disclosing a mild steepening of the gradient since Galaxy formation, with a slope change of 0.01 dex. The time evolution is slightly higher (∼0.015 dex) when we select the best available abundances in the literature. This result broadly agrees with previous PN results, but is now based on Gaia DR3 analysis, and it also agrees with what has been traced by most other Galactic probes. We also find a moderate oxygen enrichment when comparing the PNe with young and old progenitors.
Comparative Morphology of Island and Inland Agastache rugosa and Their Gastroprotective Effects in EtOH/HCl-Induced Gastric Mucosal Gastritis
Authors: Song Jun-Ho , Nam Hyeon-Hwa , Park Inkyu , Yang Sungyu , Chun Jin Mi , Seo Yun-Soo , Kim Hyun-Yong , Moon Byeong Cheol , Kang Sohi , Moon Changjong , Kang Seong-IL , Song Ji Hoon , Kim Joong-Sun 
Published: October 2023

Abstract
Agastache rugosa Kuntze (Lamiaceae; Labiatae), a medicinal and functional herb used to treat gastrointestinal diseases, grows well both on islands and inland areas in South Korea.
Thus, we aimed to reveal the morphological and micromorphological differences between A. rugosa grown on island and inland areas and their pharmacological effects on gastritis in an
animal model by combining morphological and mass spectrophotometric analyses. Morphological analysis showed that island A. rugosa had slightly smaller plants and leaves than inland
plants; however, the density of all types of trichomes on the leaves, petioles, and stems of island A. rugosa was significantly higher than that of inland plants. The essential oil
component analysis revealed that pulegone levels were substantially higher in island A. rugosa than in inland A. rugosa. Despite the differences between island and inland
A. rugosa, treatment with both island and inland A. rugosa reduced gastric damages by more than 40% compared to the gastritis induction group. In addition, expression of
inflammatory protein was reduced by about 30% by treatment of island and inland A. rugosa. The present study demonstrates quantitative differences in morphology and volatile
components between island and inland plants; significant differences were not observed between the gastritis-inhibitory effects of island and inland A. rugosa, and the efficacy of
island A. rugosa was found to be similar to that of A. rugosa grown in inland areas.
Base-Catalyzed Deprotection of Aldehydes: A New Haloform Reaction
Authors: Abulipizi Gulizhabaier , Abuduwaili Kadierya , Maihemuti Mailikezhati , Abulikemu Abudu Rexit , Tian Shiying 
Published: October 2023

AbstractAn efficient procedure for the deprotection of α,α,α-trihalogen (Cl, Br) methyl alcohols under mild reaction conditions to produce the corresponding aldehydes and haloforms is described. This method can be applied to the deprotection of aromatic, aliphatic, and heterocyclic trihalomethyl alcohol compounds.
[4+1] Cyclizations to Enantiopure Multifunctional Cyclopentanes from d-Glucose Using Formyl Dianion Synthons
Authors: Schaumann Ernst , Kirschning Andreas , Oelze Silke , Bräuer Nico , Michel Tycho 
Published: October 2023

AbstractThe [4+1] cyclization of a sugar-based epoxytosylate with various C1 dianion equivalents provide highly functionalized homochiral cyclopentane derivatives. For these, a follow-up chemistry was developed to provide various cyclopentane building blocks as starting points for natural product syntheses. The [4+1] domino protocol relies on a 1,4-Brook rearrangement, which is essential for generating the second carbanion.
Management of foreign body ingestion in adults: Time to STOP and rethink endoscopy
Authors: Tambakis George , Schildkraut Tamar , Delaney Isabella , Gilmore Robert , Loebenstein Moshe , Taylor Andrew , Holt Bronte , Tsoi Edward H , Cameron Georgina , Demediuk Barbara , Miller Ashley , Connell William , Wright Emily , Thompson Alexander , Holmes Jacinta 
Published: October 2023

Abstract
Background and study aims Foreign body ingestion is a common cause for Emergency Department presentation. In adults, foreign body ingestion is more common in patients with underlying psychiatric comorbidity, the elderly, alcohol intoxication, and in prisoners. This study reviewed the management of patients presenting to a tertiary hospital with foreign body ingestion.
Patients and methods A retrospective review of patients presenting with foreign body ingestion to a tertiary hospital in Melbourne, Victoria, was undertaken from January 2017 to December 2021. Data collected included patient demographics, type of foreign body, length of stay, imaging modalities, management strategies, and complications. High-risk ingestion was defined as sharp objects, length >5 cm, diameter >2.5 cm, button battery and/or magnet ingestion or esophageal as per international guidelines.
Results A total of 157 presentations by 63 patients with foreign body ingestion occurred between 2017 and 2021 (50% male; median age 30 years). Of the patients, 56% had underlying psychiatric comorbidities. The majority of presentations occurred in prisoners (65%). The most commonly ingested objects were batteries (23%), alleged drug-containing balloons (17%), razor blades (16%), and miscellaneous (40%). High-risk ingestion occurred in approximately two-thirds of presentations. Conservative management was the most common approach in 55% of patients. Complications, defined as perforation, bowel obstruction or fistula formation, did not occur in this cohort despite more than half presenting with high-risk ingestions. Thirty-day re-presentation rates were high (31%) and that was most common in patients with intentional ingestion, underlying mental health disorders, and a documented history of self-harm.
Conclusions Conservative management for patients presenting with recurrent high-risk foreign body ingestion was safe in appropriately selected cases. Re-presentation is common and poses significant challenges for health care providers.