bluuebunny/crossref_metadata_2025_split huggingface dataset:
A brief version of the Scale of Emotional Development – Short
Authors: Sappok T. , Barrett B. , Lutter S. 
Published: January 2024

AbstractBackgroundThe Scale of Emotional Development – Short (SED‐S) captures the level of emotional development in persons with a disorder of intellectual development (DID) with 200 items on five developmental levels. The study aims to develop a brief version of the SED‐S.MethodsBased on item analysis (proportions, χ2‐test, Spearman's ρ and corrected item–total correlation), a brief version of the SED‐S was developed in a sample of 224 adults with a DID (n1) and validated in a second independent matched sample (n2 = 223).ResultsItem reliability ranged per item set from Cronbach's α = 0.835 to 0.924. Weighted kappa resulted in κω = 0.743 (P < 0.001, 95% confidence interval = 0.690–0.802). Overall agreement of the brief version with the original SED‐S was PO = 0.7. The brief version of the SED‐S showed weaknesses in distinguishing level 2 from the adjacent levels.ConclusionsThe brief version of the SED‐S showed good reliability and moderate to good validity results. Items of phase 2 and, to some degree, of phase 5 should be revised to further improve the psychometric properties of the scale.
Tertiary lymphoid structures in tongue cancer: Association with clinicopathological parameters, preoperative S‐1 chemotherapy response, and prognosis
Authors: Seki Mai , Sano Takaaki , Saito Emi , Ogawa Masaru , Yokoo Satoshi , Oyama Tetsunari 
Published: January 2024

AbstractBackgroundTertiary lymphoid structures (TLSs) are observed in cancer‐invasive sites of various organs, and show evidence of tumor‐specific B and/or T cells, suggesting an active humoral antitumor response. The aim of this study was to evaluate the relationship between TLSs and prognosis in patients with tongue squamous cell carcinoma (TSCC) after preoperative S‐1 chemotherapy.MethodsAmong 196 TSCC cases, 111 patients who received preoperative S‐1 chemotherapy were compared to 85 patients who did not receive chemotherapy. We investigated the incidence of TLSs in both preoperative biopsy and resected specimens.ResultsTLSs were present in 24 (12%) biopsy specimens and 31 (16%) resected specimens. TLSs were associated with clinicopathologically advanced cases and positivity for lymphatic invasion. None of the cases with pStage 0 (i.e., noninvasive cancer) showed TLSs. In preoperative S‐1 chemotherapy cases, TLSs were significantly more common in those treated with S‐1 for more than 21 days and in those with treatment effects 0, Ia, and Ib. TLSs may not be a favorable prognostic factor by themselves but maybe a prognostic factor when combined with preoperative S‐1 treatment.ConclusionThe presence of TLSs was suggested to be a factor indicating a favorable prognosis when considering the indication for preoperative S‐1 chemotherapy. The synergistic effect of S‐1 by activating antitumor immunity may be associated with a better prognosis in TSCC patients with TLSs.
Structural priming: An experimental paradigm for mapping linguistic representations
Authors: Cai Zhenguang G. , Zhao Nan 
Published: January 2024

AbstractPrevious reviews have extensively explored structural priming, but there is a noticeable absence of comprehensive discussion on its potential as a tool for mapping linguistic representations in various fields. This paper addresses this gap by reviewing studies that have utilised structural priming to tackle psycholinguistic issues beyond the persistence of syntactic structures itself. We discuss how structural priming can be employed to map syntactic representations and processes that underlie sentence comprehension, to decipher grammatical encoding in sentence production, to probe the way lexical entries interrelate, to arbitrate alternative syntactic analyses for disputed constructions in experimental syntax, and to illuminate linguistic representations in large language models. We conclude that structural priming, as an experimental paradigm, presents an exciting and promising pathway towards a nuanced, empirically‐grounded understanding of linguistic representations and processes.
Assessing the accuracy of phase equilibrium software in reproducing the liquidus multiple saturation conditions of lunar and Martian basalt compositions
Authors: Astudillo Manosalva Daniel F. , Elardo Stephen M. 
Published: January 2024

AbstractAccurate computational modeling allows the use of software as a first approach to some petrological problems that typically require experimentation, but most programs have not yet been fully tested for accuracy with lunar or Martian melt compositions. The programs pMELTS, MAGPOX, and Perple_X stand out for phase equilibrium modeling, as their calibrations include experiments of lunar compositions or have precise thermodynamic constraints for similar compositions. A set of lunar mare basalts, picritic glasses, and basaltic Martian compositions with known experimentally determined multiple saturation point (MSP) conditions were used here for phase equilibrium modeling. The accuracy of each program was tested through the determination of MSPs on the liquidus of the selected compositions. This point in pressure–temperature space can be considered as a direct proxy of the stable phases and the equilibrium conditions during partial melting of mantle sources. We identify a trend in experimental data between MSP temperature and MgO, CaO, and SiO2concentrations, and similar trends are found in model results. However, only Perple_X is able to closely match the experimental data, despite the fact it does not accurately model ilmenite saturation for high‐Ti lunar basalts. We find that pMELTS miscalculates olivine saturation for MgO‐rich compositions and MAGPOX systematically underestimates MSP pressure and temperatures and can only be used when olivine is the liquidus phase. For modeling lunar or Martian basalt compositions, Perple_X can be used for optimal results, although no software is yet capable of bypassing the need to constrain MSP conditions through experimentation.
Paravertebral Muscular Neurophysiological Function as an Independent Outcome Predictor of Recurring Herniation/Low Back Pain after Radiofrequency Ablation: A Prospective Follow‐Up and Case‐Control Study Based on Surface Electromyography
Authors: Li Jian , Xing Gengyan , Lu Pengfei , Ding Yi 
Published: January 2024

ObjectiveSpinal endoscopy radiofrequency is a minimally invasive technique for lumbar disc herniation (LDH) and low back pain (LBP). However, recurring LDH/LBP following spinal endoscopy radiofrequency is a significant problem. Paravertebral musculature plays a crucial role in spine stability and motor function, and the purpose of the present study was to identify whether patients’ baseline lumbar muscular electrophysiological function could be a predictor of recurring LDH/LBP.MethodsThis was a prospective follow‐up and case‐control study focusing on elderly patients with LDH who were treated in our department between January 1, 2018, and October 31, 2021. The end of follow‐up was recurring LBP, recurring LDH, death, missing to follow‐up or 2 years postoperation. The surface electromyography test was performed before the endoscopy C‐arm radiofrequency (ECRF) operation to detect the flexion–relaxation ratio (FRR) of the lumbar multifidus (FRRLM) and the longissimus erector spinae (FRRES), and the other baseline parameters included the general characteristics, the visual analogue scale, the Japanese Orthopaedic Association score, and the Oswestry Disability Index. Intergroup comparisons were performed by independent t‐test and χ2‐test, and further binary logistic regression analysis was performed.ResultsFifty‐four patients completed the 2‐year follow‐up and were retrospectively divided into a recurring LDH/LBP group (Group R) (n = 21) and a no recurring group (Group N) (n = 33) according to their clinical outcomes. FRRLM and FRRES in Group N were much higher than those in Group R (p < 0.001, p = 0.009). Logistic regression analysis showed that only the FRRLM (odds ratio [OR] = 0.123, p = 0.011) and FRRES (OR = 0.115, p = 0.036) were independent factors associated with the ECRF outcome.ConclusionsLumbar disc herniation patients’ baseline FRRLM and FRRES are independent outcome predictors of recurring LDH/LBP after ECRF. For every unit increase in baseline FRRLM, the risk of recurring LDH/LBP is decreased by 87.7%, and for every unit increase in baseline FRRES, the risk of recurring LDH/LBP is decreased by 88.5%.
Building extraction from oblique photogrammetry point clouds based on PointNet++ with attention mechanism
Authors: Hu Hong , Tan Qing , Kang Ruihong , Wu Yanlan , Liu Hui , Wang Baoguo 
Published: January 2024

AbstractUnmanned aircraft vehicles (UAVs) capture oblique point clouds in outdoor scenes that contain considerable building information. Building features extracted from images are affected by the viewing point, illumination, occlusion, noise and image conditions, which make building features difficult to extract. Currently, ground elevation changes can provide powerful aids for the extraction, and point cloud data can precisely reflect this information. Thus, oblique photogrammetry point clouds have significant research implications. Traditional building extraction methods involve the filtering and sorting of raw data to separate buildings, which cause the point clouds to lose spatial information and reduce the building extraction accuracy. Therefore, we develop an intelligent building extraction method based on deep learning that incorporates an attention mechanism module into the Samling and PointNet operations within the set abstraction layer of the PointNet++ network. To assess the efficacy of our approach, we train and extract buildings from a dataset created using UAV oblique point clouds from five regions in the city of Bengbu, China. Impressive performance metrics are achieved, including 95.7% intersection over union, 96.5% accuracy, 96.5% precision, 98.7% recall and 97.8% F1 score. And with the addition of attention mechanism, the overall training accuracy of the model is improved by about 3%. This method showcases potential for advancing the accuracy and efficiency of digital urbanization construction projects.
A Novel Gait Event Detection Algorithm Using a Thigh-Worn Inertial Measurement Unit and Joint Angle Information
Authors: Strick Jacob A. , Farris Ryan J. , Sawicki Jerzy T. 
Published: January 2024

Abstract
This paper describes the development and evaluation of a novel, threshold-based gait event detection algorithm utilizing only one thigh inertial measurement unit (IMU) and unilateral, sagittal plane hip and knee joint angles. The algorithm was designed to detect heel strike (HS) and toe off (TO) gait events, with the eventual goal of detection in a real-time exoskeletal control system. The data used in the development and evaluation of the algorithm were obtained from two gait databases, each containing synchronized IMU and ground reaction force (GRF) data. All database subjects were healthy individuals walking in either a level-ground, urban environment or a treadmill lab environment. Inertial measurements used were three-dimensional thigh accelerations and three-dimensional thigh angular velocities. Parameters for the TO algorithm were identified on a per-subject basis. The GRF data were utilized to validate the algorithm's timing accuracy and quantify the fidelity of the algorithm, measured by the F1-Score. Across all participants, the algorithm reported a mean timing error of −41±20 ms with an F1-Score of 0.988 for HS. For TO, the algorithm reported a mean timing error of −1.4±21 ms with an F1-Score of 0.991. The results of this evaluation suggest that this algorithm is a promising solution to inertial based gait event detection; however, further refinement and real-time evaluation are required for use in exoskeletal control.
Thermo-Economic Analysis of Solar-Powered Trigeneration System With Integrated Ejector-Absorption Recompression and Modified Organic Rankine Cycle
Authors: Mishra Shubham Kumar , Rehalia Amrit Singh , Verma Ashutosh Kumar , Yadav Laxmikant 
Published: January 2024

Abstract
In this study, the organic Rankine cycle (ORC) and hybrid absorption recompression cycle have been modified by the addition of turbine bleeding with regeneration and ejector, making it a unique solar-powered trigeneration system. With this modification, the useful electric power increases by 65 kW due to increased mass flowrate and overall efficiency nearly by 0.7%, and this difference grows as direct normal irradiation (DNI) rises. After identifying these improvements, a parametric study was conducted to determine the optimum value of these operating variables, such as direct normal irradiation, condenser pressure, turbine inlet temperature, and pressure ratio based on the desired outputs and efficiencies of the proposed modified systems. The results indicate that the proposed system is capable of simultaneously generating 315.3 kW of electric power, 1588 kW of heating output, and 501.6 kW of cooling at energy and exergy efficiencies of 80.8% and 25.36%, respectively. Further, in terms of energy one could conclude that only 19.2% of total available energy is getting wasted, but in reality, around 75% of the work potential of the input exergy is getting wasted. The maximum exergy is lost at the solar collector and destructed at heat recovery vapor generator (HRVG), hence requiring careful design to improve their performance. Lastly, an economic analysis of the proposed system has also been conducted, and the payback period is found to be 2.33 years, which ensures its economic viability.
Assessment of the correlation between optical properties and CQD preparation approaches
Authors: Ateia Ebtesam E. , Rabie Obaida , Mohamed Amira T. 
Published: January 2024

AbstractVarious production procedures, for carbon quantum dots (CQDs), are still being extensively researched to understand the nature of CQD luminescence. This study compares and examines the impact of chemical as well as green methods on the structural and optical properties of CQDs. We present a straightforward, cost-effective bottom-up method for producing fluorescent CQDs from lemon peels (L-CQDs), orange juice (O-CQDs), and citric acid (C-CQDs) without having to deal with time-consuming or ineffective post-processing processes. The proposed green synthesis has no toxic by-products, and the residual resources utilized promote the large-scale production of CQDs. X-ray diffraction, high-resolution transmission electron microscopy, FTIR, Raman, DLS, and UV–Vis spectroscopy are utilized to investigate the structure and optical characteristics of the prepared CQDs. The as-prepared CQDS possess small particle sizes of 5.6 nm, 6.2 nm, and 1.1 nm for L-CQDs, O-CQDs, and C-CQDs samples, respectively. FTIR results reveal the coexistence of carboxylic and hydroxyl groups on the surface of the CQDs, as also supported by zeta-potential values. Maximal fluorescence intensity was reached at excitation wavelengths of 365, 250, and 280 nm with an emission color of blue, indigo, and light blue for L-CQDs, O-CQDs, and C-CQDs, respectively. The presented approaches show a high quantum yield of 88% for O-CQDs, 49% for L-CQDs, and 37% for C-CQDs. Due to their minuscule particle size, perfect water solubility, high stability, and tunable luminescence properties, the prepared CQDs are preferred for potential applications in multicolor imaging, metal ion sensing, and wastewater technologies.
Abstract A016: LINC00261 is functionally linked to tumor DNA mutational burden and tumor immune microenvironment composition in lung adenocarcinoma
Authors: Castillo Jonathan , Xue Tianchun , Norwood Mayela , Joseph Samantha , Epstein Alan L. , Wallace W. Dean , Kim Anthony W. , Marconett Crystal N. 
Published: January 2024

Abstract
Immunotherapy has emerged as a breakthrough in the improvement of survival outcomes for lung adenocarcinoma (LUAD), however effective response requires the combination of blocking inhibitory signals on the tumor surface and antigen presentation to the tumor surface for proper immune recognition. Several commercially available and robust methods exist for identification of tumors displaying immune-inhibitory surface receptors, such as PD-L1, however it is currently difficult to predict effectiveness of antigen presentation on the cell surface. To address this, we utilized clinical and next-generation sequencing data from The Cancer Genome Atlas (TCGA) to identify gene signatures that are correlated to tumor mutational burden (TMB) within cancers of epithelial origins as a surrogate for neoantigen signatures. We identified LINC00261 as a top gene correlated to TMB, whose expression activates DNA damage response pathways in vitro along with resistance to cisplatin. LINC00261 expression was also significantly correlated to MHC class I and II genes involved in endogenous neoantigen presentation expression within the TCGA-LUAD cohort. This relationship was confirmed in vitro through ectopic reintroduction of LINC00261 for key MHC class II presentation genes. Interferon gamma-induced MHC gene activation in vitro was also able to induce endogenous expression of LINC00261. The staining of primary human lung cancer sections suggested that loss of LINC00261 is associated with an immunosuppressive tumor microenvironment. Taken together, our results suggest there is a mechanistic relationship in the silencing of LINC00261 in LUAD and compromised DNA repair, accumulation of mutations, and reduced antitumor immune response.
Citation Format: Jonathan Castillo, Tianchun Xue, Mayela Norwood, Samantha Joseph, Alan L. Epstein, W. Dean Wallace, Anthony W. Kim, Crystal N. Marconett. LINC00261 is functionally linked to tumor DNA mutational burden and tumor immune microenvironment composition in lung adenocarcinoma [abstract]. In: Proceedings of the AACR Special Conference in Cancer Research: DNA Damage Repair: From Basic Science to Future Clinical Application; 2024 Jan 9-11; Washington, DC. Philadelphia (PA): AACR; Cancer Res 2024;84(1 Suppl):Abstract nr A016.
Abstract A023: High glucose increases DNA damage and elevates the expression of multiple DDR genes
Authors: Rahmoon Mai A. , Elghaish Reem A. , Ibrahim Aya A. , Alaswad Zina , Gad Mohamed Z. , El-Khamisy Sherif F. , Elserafy Menattallah 
Published: January 2024

Abstract
The DNA Damage Response (DDR) pathways sense DNA damage and coordinate robust DNA repair and bypass mechanisms. A series of repair proteins are recruited depending on the type of breaks and lesions to ensure overall survival. An increase in glucose levels was shown to induce genome instability, yet the links between DDR and glucose are still not well investigated. In this study, we aimed to identify dysregulation in the transcriptome of normal and cancerous breast cell lines upon changing glucose levels. We first performed bioinformatics analysis using a microarray dataset containing the triple-negative breast cancer (TNBC) MDA-MB-231 and the normal human mammary epithelium MCF10A cell lines grown in high glucose (HG) or in the presence of the glycolysis inhibitor 2-deoxyglucose (2DG). Interestingly, multiple DDR genes were significantly upregulated in both cell lines grown in HG. In the wet lab, we remarkably found that HG results in severe DNA damage to TNBC cells as observed using the comet assay. In addition, several DDR genes were confirmed to be upregulated using qPCR analysis in the same cell line. Our results propose a strong need for DDR pathways in the presence of HG to oppose the severe DNA damage induced in cells.
Citation Format: Mai A. Rahmoon, Reem A. Elghaish, Aya A. Ibrahim, Zina Alaswad, Mohamed Z. Gad, Sherif F. El-Khamisy, Menattallah Elserafy. High glucose increases DNA damage and elevates the expression of multiple DDR genes [abstract]. In: Proceedings of the AACR Special Conference in Cancer Research: DNA Damage Repair: From Basic Science to Future Clinical Application; 2024 Jan 9-11; Washington, DC. Philadelphia (PA): AACR; Cancer Res 2024;84(1 Suppl):Abstract nr A023.
Abstract B031: Evaluating the consequence of homologous recombination deficiency in models of pediatric solid tumor
Authors: Savage Evan , Xu Ke , Myer Jason , Rampersaud Evadnie , Hui Yawei , Chang Ti-Cheng , Wu Gang , Tinkle Christopher , Shelat Anang 
Published: January 2024

Abstract
Homologous recombination deficiency (HRD) has been extensively studied in adult cancers where its association with sensitivity to Poly (ADP-ribose) polymerases (PARP) inhibitor sensitivity is well established. In these cancers, HRD is most frequently caused by biallelic inactivation of BRCA1/2 and tumors often exhibit characteristic genomic scars such as elevated HRD.sum score and specific mutational signatures derived from single nucleotide variants, insertions and deletions, and structural variants. Despite its clinical relevance, the therapeutic predictive value of HRD has not been systematically studied in pediatric cancers. Consequently, our team devised a strategy to identify and validate targetable deficiencies in DNA damage response (DDR) genes and assess genomic scars in pediatric tumors. Here, we report evaluation of HRD in a cohort of &gt;200 patient-derived orthotopic xenograft models from the Childhood Solid Tumor Network (CSTN), a freely sharing resource established by our institution to accelerate the development of therapies for children with cancer. We provide an overview of our pipeline and discuss the landscape of genomic scars within our cohort. We profiled somatic and germline variants from over 500 DNA damage response genes and identified TP53 as the most frequently mutated gene with biallelic loss, whereas bi-allelic loss of BRCA1/2 was not found. Overall, our study suggests that HRD exists within solid tumors, but is driven by inactivation of genes other than BRCA1/2, resulting in a different set of genomic scars compared to those in adult cancers where HRD is common. Importantly, the CSTN contains models of pediatric solid tumors that are amenable to in vitro and in vivo interrogation, and therefore, will facilitate examination of the functional consequences of inactivated DDR genes, characterization of the unique genomic scar profiles underlying these inactivation events, and evaluation of novel therapeutic strategies.
Citation Format: Evan Savage, Ke Xu, Jason Myer, Evadnie Rampersaud, Yawei Hui, Ti-Cheng Chang, Gang Wu, Christopher Tinkle, Anang Shelat. Evaluating the consequence of homologous recombination deficiency in models of pediatric solid tumor [abstract]. In: Proceedings of the AACR Special Conference in Cancer Research: DNA Damage Repair: From Basic Science to Future Clinical Application; 2024 Jan 9-11; Washington, DC. Philadelphia (PA): AACR; Cancer Res 2024;84(1 Suppl):Abstract nr B031.