bluuebunny/crossref_metadata_2025_split huggingface dataset:
Protein arginine methyltransferase 5 mediates arginine symmetric dimethylation of influenza A virus PB2 and supports viral replication
Authors: Sun Huimin , Tu Shaoyu , Luo Didan , Dai Chao , Jin Meilin , Chen Huanchun , Zou Jiahui , Zhou Hongbo 
Published: October 2023

AbstractInfluenza A virus (IAV) relies on intricate and highly coordinated associations with host factors for efficient replication and transmission. Characterization of such factors holds great significance for development of anti‐IAV drugs. Our study identified protein arginine methyltransferase 5 (PRMT5) as a novel host factor indispensable for IAV replication. Silencing PRMT5 resulted in drastic repression of IAV replication. Our findings revealed that PRMT5 interacts with each protein component of viral ribonucleoproteins (vRNPs) and promotes arginine symmetric dimethylation of polymerase basic 2 (PB2). Overexpression of PRMT5 enhanced viral polymerase activity in a dose‐dependent manner, emphasizing its role in genome transcription and replication of IAV. Moreover, analysis of PB2 protein sequences across various subtypes of IAVs demonstrated the high conservation of potential RG motifs recognized by PRMT5. Overall, our study suggests that PRMT5 supports IAV replication by facilitating viral polymerase activity by interacting with PB2 and promoting its arginine symmetric dimethylation. This study deepens our understanding of how IAV manipulates host factors to facilitate its replication and highlights the great potential of PRMT5 to serve as an anti‐IAV therapeutic target.
Effects of biochar and compost addition in potting substrates on growth and volatile compounds profile of basil (Ocimum basilicum L.)
Authors: Nocentini Marco , Mastrolonardo Giovanni , Michelozzi Marco , Cencetti Gabriele , Lenzi Anna , Panettieri Marco , Knicker Heike , Certini Giacomo 
Published: October 2023

AbstractBACKGROUNDDespite the optimal characteristics of peat, more environmental‐friendly materials are needed in the nursery sector, although these must guarantee specific quantitative and qualitative commercial standards. In the present study, we evaluated the influence of biochar and compost as peat surrogates on yield and essential oil profile of two different varieties of basil (Ocimum basilicum var. Italiano and Ocimum basilicum var. minimum). In two 50‐day pot experiments, we checked the performances of biochar from pruning of urban trees and composted kitchen scraps, both mixed in different proportions with commercial peat (first experiment), and under different nitrogen (N) fertilization regimes (second experiment), in terms of plant growth and volatile compounds profile of basil.RESULTSTotal or high substitution of peat with biochar (100% and 50% v.v.) or compost (100%) resulted in seedling death a few days from transplantation, probably because the pH and electrical conductivity of the growing media were too high. Substrates with lower substitution rates (10–20%) were underperforming in terms of plant growth and color compared to pure commercial peat during the first experiment, whereas better performances were obtained by the nitrogen‐fertilized mixed substrates in the second experiment, at least for one variety. We identified a total of 12 and 16 aroma compounds of basil (mainly terpenes) in the two experiments. Partial replacement of peat did not affect basil volatile organic compounds content and composition, whereas N fertilization overall decreased the concentration of these compounds.CONCLUSIONOur results support a moderate use of charred or composted materials as peat surrogates. © 2023 The Authors. Journal of The Science of Food and Agriculture published by John Wiley & Sons Ltd on behalf of Society of Chemical Industry.
Signaling Pathways Triggering Therapeutic Hydrogels in Promoting Chronic Wound Healing
Authors: Chen Fang , Wu Pingli , Zhang Haisong , Sun Guoming 
Published: October 2023

AbstractIn recent years, there has been a significant increase in the prevalence of chronic wounds, such as pressure ulcers, diabetic foot ulcers, and venous ulcers of the lower extremities. The main contributors to chronic wound formation are bacterial infection, prolonged inflammation, and peripheral vascular disease. However, effectively treating these chronic wounds remains a global challenge. Hydrogels have extensively explored as wound healing dressing because of their excellent biocompatibility and structural similarity to extracellular matrix (ECM). Nonetheless, much is still unknown how the hydrogels promote wound repair and regeneration. Signaling pathways play critical roles in wound healing process by controlling and coordinating cells and biomolecules. Hydrogels, along with their therapeutic ingredients that impact signaling pathways, have the potential to significantly enhance the wound healing process and its ultimate outcomes. Understanding this interaction will undoubtedly provide new insights into developing advanced hydrogels for wound repair and regeneration. This paper reviews the latest studies on classical signaling pathways and potential targets influenced by hydrogel scaffolds in chronic wound healing. This work hopes that it will offer a different perspective in developing more efficient hydrogels for treating chronic wounds.
One‐Pot/Simultaneous Synthesis of PHPMA‐G‐PLA Copolymers via Metal‐Free Rop/Raft Polymerization and their Self‐Assembly from Micelles to Thermoresponsive Vesicles
Authors: Lukáš Petrova Svetlana , Sincari Vladimir , Konefał Rafał , Pavlova Ewa , Lobaz Volodymyr , Kočková Olga , Hrubý Martin 
Published: October 2023

AbstractThe present article reports a simple and straightforward approach to access thermoresponsive graft copolymers based on lactide (LA) and a methacrylic monomer, 2‐hydroxypropyl methacrylate (HPMA), using a synthesized carboxy‐functionalized trithiocarbonate‐based chain transfer agent. One protocol involves a metal‐free simultaneous synthesis through a combination of reversible addition‐fragmentation chain transfer polymerization and organic acid‐catalyzed ring‐opening polymerization, which follows first‐order kinetics. The resulting copolymers with a controlled structure exhibit remarkably narrow molecular weight distributions (Ð < 1.10). Within this framework, the self‐assembly of PHPMA‐g‐PLA graft copolymers (GCs) into nanoparticles (NPs) is demonstrated at concentrations of 0.2 and 0.5 wt.%, respectively. The displacement method, based on the rapid injection of the organic solvent (acetone) into an aqueous medium under vigorous stirring, produces spherical NPs such as micelles, vesicles, or non‐spherical “lumpy rods”. The presence of a pseudo‐thermoresponsive segment (PHPMA) in GCs facilitates stimulus‐responsive self‐assembly behavior. Well‐defined spherical NPs—primarily vesicles of substantial size—develop upon heating above the glass transition temperature (Tg ≈35–36 °C) of the GCs in an acetone–water (80/20 wt.%) mixture. Last, specific interactions between the obtained PHPMA‐g‐PLA nano‐objects and blood proteins in human plasma are studied using isothermal calorimetry.
A meta‐analysis on peer‐to‐peer accommodation adoption
Authors: Ashaduzzaman Md , Weaven Scott , Ross Mitchell , Jebarajakirthy Charles , Surachartkumtonkun Jiraporn , Maseeh Haroon Iqbal 
Published: October 2023

AbstractPeer‐to‐peer‐accommodation, a sharing economy‐based business model, enables using unutilized houses, apartments, and rooms of individuals to provide shared accommodation to tourists and travelers. On account of the importance of peer‐to‐peer accommodation, many studies have been conducted on factors/stimuli driving peer‐to‐peer accommodation adoption; however, findings remain inconsistent and fragmented. Accordingly, using the stimulus‐organism‐response model, this meta‐analysis provides generalized findings on determinants driving peer‐to‐peer accommodation adoption. Our meta‐analysis shows that stimuli (service characteristics, psychological aspects, social aspects, and technological aspects) drive the organism (perceived service quality) which in turn drives peer‐to‐peer accommodation adoption. Further, our moderation analysis shows that the relationship between these stimuli and the organism, and the relationship between the organism and peer‐to‐peer accommodation adoption, vary depending on four moderators: sample type, country of study, survey administration method, and sample size. Overall, this study contributes to the stimulus‐organism‐response theory by extending it to the meta‐analytical approach and suggesting a new organism for inclusion in the original stimulus‐organism‐response model. This meta‐analysis also contributes to the peer‐to‐peer accommodation and sharing economy literature and provides practical recommendations for accommodation platform providers and their listed houses to develop marketing strategy and policy.
Environment Endurable, Self‐Healing, Super‐Adhesive, and Mechanically Strong Ionogels for Reliable Sensing
Authors: Jin Zhengxu , Liu Hongyan , Zhang Huijuan 
Published: October 2023

AbstractIonogels possess high conductivity, stretchability, and adhesion, making them promising as flexible sensors. However, it remains challenging to fabricate an ionogel which integrates excellent environment endurance, superior mechanical strength, high self‐healing efficiency, and super adhesion. Herein, a supramolecular ionic liquid is synthesized using calcium chloride and 1‐butyl‐3‐methylimidazolium chloride. An advanced ionogel based on this supramolecular ionic liquid is conveniently constructed by a one‐pot method with acrylamide and acrylic acid as monomers. The supramolecular cross‐linking network, formed by affluent coordination interactions, hydrogen bonds, and electrostatic interactions, provides the ionogel with ideal mechanical strength (tensile strength up to 1.7 MPa), high self‐healing efficiency (up to 149%), super adhesion (up to 358 kPa on aluminum), excellent solvent tolerance (less than 10% weight increase, high mechanical and sensing performance retention after being soaked in organic solvents), and low‐temperature endurance (breaking elongation can reach 87% at −30 °C). The supramolecular ionogels can function as multi‐mode sensors, capable of monitoring strain and different amplitudes of human movements in real‐time. Moreover, the sensing performance of ionogels remains unaffected even after being self‐healed or exposure to organic solvents. It is expected that this study could offer valuable design ideas to construct advanced gel materials applicable in complicated environment.
Technical note: Evaluation of deep learning based synthetic CTs clinical readiness for dose and NTCP driven head and neck adaptive proton therapy
Authors: de Koster Rutger J C , Thummerer Adrian , Scandurra Daniel , Langendijk Johannes A , Both Stefan 
Published: October 2023

AbstractBackgroundAdaptive proton therapy workflows rely on accurate imaging throughout the treatment course. Our centre currently utilizes weekly repeat CTs (rCTs) for treatment monitoring and plan adaptations. However, deep learning‐based methods have recently shown to successfully correct CBCT images, which suffer from severe imaging artifacts, and generate high quality synthetic CT (sCT) images which enable CBCT‐based proton dose calculations.PurposeTo compare daily CBCT‐based sCT images to planning CTs (pCT) and rCTs of head and neck (HN) cancer patients to investigate the dosimetric accuracy of CBCT‐based sCTs in a scenario mimicking actual clinical practice.MethodsData of 56 HN cancer patients, previously treated with proton therapy was used to generate 1.962 sCT images, using a previously developed and trained deep convolutional neural network. Clinical IMPT treatment plans were recalculated on the pCT, weekly rCTs and daily sCTs. The dosimetric accuracy of sCTs was compared to same day rCTs and the initial planning CT. As a reference, rCTs were also compared to pCTs. The dose difference between sCTs and rCTs/pCT was quantified by calculating the D98 difference for target volumes and Dmean difference for organs‐at‐risk. To investigate the clinical relevancy of possible dose differences, NTCP values were calculated for dysphagia and xerostomia.ResultsFor target volumes, only minor dose differences were found for sCT versus rCT and sCT versus pCT, with dose differences mostly within ±1.5%. Larger dose differences were observed in OARs, where a general shift towards positive differences was found, with the largest difference in the left parotid gland. Delta NTCP values for grade 2 dysphagia and xerostomia were within ±2.5% for 90% of the sCTs.ConclusionsTarget doses showed high similarity between rCTs and sCTs. Further investigations are required to identify the origin of the dose differences at OAR levels and its relevance in clinical decision making.
Reproducibility of 3D thoracic aortic displacement from 3D cine balanced SSFP at 3 T without contrast enhancement
Authors: Merton Renske , Bosshardt Daan , Strijkers Gustav J. , Nederveen Aart J. , Schrauben Eric M. , van Ooij Pim 
Published: October 2023

AbstractPurposeAortic motion has direct impact on the mechanical stresses acting on the aorta. In aortic disease, increased stiffness of the aorta may lead to decreased aortic motion over time, which could be a predictor for aortic dissection or rupture. This study investigates the reproducibility of obtaining 3D displacement and diameter maps quantified using accelerated 3D cine MRI at 3 T.MethodsA noncontrast‐enhanced, free‐breathing 3D cine sequence based on balanced SSFP and pseudo‐spiral undersampling with high spatial isotropic resolution was developed (spatial/temporal resolution [1.6 mm]3/67 ms). The thoracic aorta of 14 healthy volunteers was prospectively scanned three times at 3 T: twice on the same day and a third time 2 weeks later. Aortic displacement was calculated using iterative closest point nonrigid registration of manual segmentations of the 3D aorta at end‐systole and mid‐diastole. Interexamination and interobserver regional analysis of mean displacement for five regions of interest was performed using Bland–Altman analysis. Additionally, a complementary voxel‐by‐voxel analysis was done, allowing a more local inspection of the method.ResultsNo significant differences were found in mean and maximum displacement for any of the regions of interest for the interexamination and interobserver analysis. The maximum displacement measured in the lower half of the ascending aorta was 11.0 ± 3.4 mm (range: 3.0–17.5 mm) for the first scan. The smallest detectable change in mean displacement in the lower half of the ascending aorta was 3 mm.ConclusionDetailed 3D cine balanced SSFP at 3 T allows for reproducible quantification of systolic–diastolic mean aortic displacement within acceptable limits.
Input‐to‐state stability of a time‐invariant system with control delay and additive disturbances
Authors: Ursu Ioan , Toader Adrian , Tecuceanu George , Enciu Daniela 
Published: October 2023

AbstractWe consider a class of linear time invariant systems with control delay and additive disturbances. A state predictive feedback method is first applied to compensate the actuator delay. In this way, a closed loop system free of delay is achieved. It allows to ensure input‐to‐state‐stability of the closed loop system. Applications are given for the lateral‐directional stability of an airplane with two controls, on the aileron and on the rudder, in correlation with compliance with some regulatory flight conditions.
Agreement and disagreement between child–caregiver symptom and function reports in pediatric oncology
Authors: Weaver Meaghann S. , Wang Jichuan , Reeve Bryce B. , Porter Amy S. , Baker Justin N. , Mack Jennifer W. , Thompson Amanda L. , Wiener Lori , Grossoehme Daniel H. , Hinds Pamela S. 
Published: October 2023

AbstractBackground/objectiveThe use of patient‐reported outcomes (PRO) is increasing in pediatric clinical practice and research, including in clinical trials. Treatment teams are now able to discern differences in symptom and function reports between children with cancer and their family caregivers. Few studies, however, have quantified such differences.Design/methodsChildren and caregivers were matched to create a dyad sample, and child/caregiver agreement of responses to the Patient‐Reported Outcome Measurement Information System (PROMIS) Pediatric symptom and function measures were examined using the established minimally important difference (MID) value (three points) derived from these measures. Latent class analysis (LCA) was then used to analyze the status/patterns of response agreement.ResultsA total of 430 dyadic cases (dyads) were used for LCA modeling. Three classes of child–caregiver concordance resulted: (a) Agreement—caregiver and child within one MID (200 dyads); (b) Disagreement—caregiver underestimating symptoms (47 dyads with caregiver scores more than 1 MID lower than the child scores); and (c) Disagreement—caregiver overestimating symptoms (183 dyads with caregiver scores more than 1 MID higher than child scores).ConclusionAs PRO use increases in pediatric oncology, clinician identification of child/caregiver differences on symptom and function reports will help to distinguish family perceptions of cancer treatment impact. The treatment goal, in addition to mitigating symptom and function treatment‐related burdens for the child and caregiver, may now also be to discern the direction and clinical meaning of the difference within the child–parent dyad.
Trichoderma‐derived emodin competes withExpRandExpIofPectobacterium carotovorumsubsp.carotovorumto biocontrol bacterial soft rot
Authors: Zhan Xin , Wang Rui , Zhang Manman , Li Yuejiao , Sun Tao , Chen Jie , Li Jishun , Liu Tong 
Published: October 2023

AbstractBACKGROUNDQuorum sensing inhibitors (QSIs) are an emerging control tool that inhibits the quorum sensing (QS) system of pathogenic bacteria. We aimed to screen for potential QSIs in the metabolites ofTrichodermaand to explore their inhibitory mechanisms.RESULTSWe screened a strain ofTrichoderma asperellumLN004, which demonstrated the ability to inhibit the color development ofChromobacterium subtsugaeCV026, primarily attributed to the presence of emodin as its key QSI component. The quantitative polymerase chain reaction with reverse transcription results showed that after emodin treatment ofPectobacterium carotovorumsubsp.carotovorum(Pcc), plant cell wall degrading enzyme‐related synthetic genes were significantly downregulated, and the exogenous enzyme synthesis gene negative regulator (rsmA) was upregulated 3.5‐fold. Docking simulations indicated that emodin could be a potential ligand for ExpI and ExpR proteins because it exhibited stronger competition than the natural ligands inPcc. In addition, western blotting showed that emodin attenuated the degradation ofn‐acylhomoserine lactone on the ExpR protein and protected it. Different concentrations of emodin reduced the activity of pectinase, cellulase, and protease inPccby 20.81%–72.21%, 8.38%–52.73%, and 3.57%–47.50%. Lesion size in Chinese cabbages, carrots and cherry tomatoes followingPccinfestation was reduced by 10.02%–68.57%, 40.17%–88.56% and 11.36%–86.17%.CONCLUSIONEmodin fromT. asperellumLN004 as a QSI can compete to bind both ExpI and ExpR proteins, interfering with the QS ofPccand reducing the production of virulence factors. The first molecular mechanism reveals the ability of emodin as a QSI to competitively inhibit two QS proteins simultaneously. © 2023 Society of Chemical Industry.
A non‐fragile approach to fault estimation for a class of multi‐rate systems under binary encoding schemes
Authors: Hou Nan , Wang Zidong , Shen Yuxuan , Liu Hongjian , Dong Hongli 
Published: October 2023

AbstractThis article is concerned with the non‐fragile fault estimation issue for a class of multi‐rate systems under binary encoding schemes (BES). A specific dynamics relationship with zero second‐order difference is employed to characterize the evolution of the actuator fault. The signal communication is regulated by the BESs, where the resulting random bit errors are characterized by a certain stochastic noise. The aim of this article is to design a fault estimator such that the estimation error dynamics is exponentially ultimately bounded in mean square. First, an equivalent single‐rate system is formulated via the lifting technique. Then, by virtue of the stochastic analysis method and the matrix inequality approach, sufficient conditions are developed to ensure the existence of the desired fault estimator. Finally, the effectiveness of the proposed estimator design strategy is testified through a simulation example.
Event‐triggered annular finite‐time H∞$$ {H}_{\infty } $$ filtering for discrete‐time mean‐field stochastic systems
Authors: Zhuang Jijing , Liu Xikui , Li Yan 
Published: October 2023

AbstractThis article presents a framework for annular finite‐time filtering problem for discrete‐time mean‐field stochastic systems with state‐ and disturbance‐dependent noise. Both static and dynamic event‐triggered mechanisms are introduced, which are related to two different thresholds and internal variables, respectively. Based on mean‐field theory and the Lyapunov functional method, two groups of sufficient conditions are derived to ensure the filtering error systems have annular finite‐time boundedness under an performance level. Then, the desired filter gains can be obtained by solving two convex optimization problems. Finally, two numerical examples are given to show the validity of the proposed results.
Towards eco‐systemic living: learning with Indigenous leaders in Africa and Indonesia through a community of practice: implications for climate change and pandemics
Authors: McIntyre‐Mills Janet J. , Lethole Patricia , Makaulule Mphathe , Wirawan Rudolf , Widianingsih Ida , Romm Norma 
Published: October 2023

AbstractThe paper reflects on the lessons from two case studies in order to discuss (1) how they address Ostrom's eight principles and (2) implications for social, economic and environmental challenges. The two case studies are of forest communities in Venda in South Africa and Ciptagelar, West Java, discussed in terms of their social, environmental and economic approaches. In both cases, the communities see themselves as related to nature; in the case of Venda, they express this as a totemic relationship and have been inspired to apply an ecological calendar that was taught to them during the time Mphatheleni Makaulule spent learning from Amazonian leaders. In the case of Ciptagelar, the nomadic way of life is based on a sense of being stewards who do not commodify rice, a sacred source of life, which is in turn dependent upon all the co‐existent creatures and ultimately the forest, which is their home. In both communities, the environment and people are priorities managed by observing the natural cycle. In both communities, an ecological calendar guides the planning and harvesting of crops. In Tshidzivhe Venda, a rigorous approach to crops, harvesting from the forest and re‐planting the forest, is observed, and the entire community act as caretakers and are required to ask permission before harvesting from the forest. In Ciptagelar, West Java, the chief reads the signs when it is time to move to another area and follows a careful approach to biodiversity ensuring that paddy is grown only for certain months so that other creatures can thrive in other months. The Balancing Individualism and Collectivism Special Integration Group has focused on learning by doing using an applied mixed methods approach. It is based on a community of practice spanning NGOs, community projects and university departments. It is supported by a small NRF fund, some funding from UNISA and in kind support from participants. We work together because of shared values and mutual respect.