bluuebunny/crossref_metadata_2025_split huggingface dataset:
Lymphatic Mapping with Contrast-enhanced Ultrasound for Lymphaticovenous Anastomosis Surgery: How We Do It
Authors: Jang Samuel , Bustos Samyd S. , Chen Austin D. , Zheng Eugene E. , Hesley Gina K. , Brinkman Nathan J. , Carter Jill S. , Tran Nho V. , Fahradyan Vahe , Lee Christine U. 
Published: October 2023

Summary:
Lymphaticovenous anastomosis (LVA) surgery is an effective surgery for the treatment of lymphedema in the extremities. Indocyanine green lymphography is the reference standard for visualizing lymphatics for LVA surgery, but it has several limitations; most notably, superficial dermal congestion can mask deeper lymphatic vessels. To overcome the limitations, we add contrast-enhanced ultrasound (CEUS) lymphography. We have previously reported that CEUS lymphography can identify lymphatic vessels for LVA surgery that indocyanine green lymphography does not. Here, we describe how we perform CEUS lymphography, including workflow, technique, and documentation. Before informed consent, the patient must be screened for possible adverse reactions to microbubbles. The procedure involves multiple intradermal injections of the microbubble agent at various sites along the extremity. After each injection, imaging for microbubble uptake by lymphatic vessels is performed using an ultrasound scanner with contrast-specific software. We use sulfur hexafluoride lipid-type A microspheres (Lumason/SonoVue; Bracco Suisse SA), but we are investigating the performance of other Food & Drug Administration–approved microbubble agents for CEUS lymphography. Having a systematic approach to marking the skin can mitigate the hindrance of marking over ultrasound coupling gel. Another benefit of CEUS lymphography is the rapid identification of neighboring veins compatible in size and location for anastomosis. We hold regular scheduled multidisciplinary meetings for coordination of care, discussion of outcomes, quality assurance, and ongoing innovation.
CARD (Comfort Ask Relax Distract) for school-based immunizations in Calgary, Canada: a pragmatic cluster trial
Authors: Taddio Anna , Coldham Joanne , Logeman Charlotte , McMurtry C. Meghan , Bucci Lucie M. , Gudzak Victoria , MacDonald Noni E. , Little Cheri , Samborn Tracy , Moineddin Rahim 
Published: October 2023

Abstract
School-based immunizations are fear-inducing events for many students and contribute to vaccine hesitancy. We developed an immunization delivery framework called the CARD (Comfort Ask Relax Distract) system that incorporates evidence-based interventions to improve the experience (eg, reduce fear, pain, dizziness). We evaluated CARD in grades 6 and 9 students in Calgary, Canada. In this pragmatic, hybrid, effectiveness-implementation, cluster trial, we randomized 8 Community Health Centres providing regional immunization services to CARD or control (usual care). In the CARD group, public health staff educated students about CARD and planned processes to reduce fear cues and support student coping choices during immunization. Students self-reported fear, pain, and dizziness during immunization using a 0-10 numerical rating scale; staff recorded procedure details, including vaccines administered, fainting episodes, and coping strategies used. Staff participated in focus groups afterward. Altogether, 8839 children from 105 schools in the 2019 to 2020 school calendar year were included. Fear was lower for CARD (mean = 3.6 [SD = 3.1] vs control 4.1 [3.2]; mean difference = −0.5; 95% confidence interval = −0.74 to −0.21; P < 0.001). Effectiveness persisted after stratification by student gender (male and female) and grade level (grade 6 and grade 9). Other symptoms did not differ. Compared with control, CARD students used peers, privacy, muscle tension, and topical anesthetics more; verbal distraction, deep breathing, and adult support were used less frequently (P < 0.05, all analyses). Immunization rate did not differ. Staff reported positive to neutral attitudes about CARD. In summary, this pragmatic trial demonstrated that CARD improved the immunization experiences of students at school.
Successful results of early nucleos(t)ide analogue treatment for liver transplantation candidates with severe acute hepatitis B infection
Authors: Özden İlgin , Kinaci Erdem , Ocak İlhan , Çolak Mustafa , Abdullah Taner , Özcan Funda Gümüş , Aydin Oğuzhan , Poturoğlu Şule 
Published: October 2023

Background
Early treatment of severe acute hepatitis B virus (HBV) infection with nucleos(t)ide analogues may prevent progression to acute liver failure (ALF).

Patients and methods
The charts of 24 patients who were treated for severe acute HBV infection (either INR ≥ 1.5 or INR≥ 1.4 and total bilirubin ≥ 20 mg/dL at the referring institution or after admission) between April 2021 and May 2023 (inclusive) were evaluated retrospectively. Twelve patients were women; median [range] age: 48 [35–68]. Entecavir (0.5 mg/day) (n = 16) or tenofovir disoproxil fumarate (245 mg/day) (n =8) were used depending on availability.

Results
Two patients required liver transplant which was performed successfully in one (no suitable donor for the other). Deterioration to ALF was prevented in 22 of the 24 cases (92%); these patients could be discharged after median (range) 12 (5–24) days following initiation of the antiviral drug. There was no significant difference in efficacy between the two antiviral agents. The anti-HBsAg antibody became positive in 16 patients (73%); one other patient became HBsAg negative at 1 month after discharge but was lost to follow up. Five patients (23%) are still HBsAg positive but all except one have started treatment in the last 6 months. One of the recently treated 4 patients stopped taking the antiviral drug at his own will and one has become anti-HIV antibody positive during follow up.

Conclusion
Early treatment of severe acute HBV infection with entecavir or tenofovir disoproxil fumarate prevents the need for liver transplant and consideration of living donors.
Modelling arterial thrombus formation in vitro
Authors: Drysdale Amelia , Zaabalawi Azziza , Jones Sarah 
Published: October 2023

Purpose of review
Models of arterial thrombus formation represent a vital experimental tool to investigate platelet function and test novel antithrombotic drugs. This review highlights some of the recent advances in modelling thrombus formation in vitro and suggests potential future directions.

Recent findings
Microfluidic devices and the availability of commercial chips in addition to enhanced accessibility of 3D printing has facilitated a rapid surge in the development of novel in-vitro thrombosis models. These include progression towards more sophisticated, ‘vessel on a chip’ models which incorporate vascular endothelial cells and smooth muscle cells. Other approaches include the addition of branches to the traditional single channel to yield an occlusive model; and developments in the adhesive coating of microfluidic chambers to better mimic the thrombogenic surface exposed following plaque rupture. Future developments in the drive to create more biologically relevant chambers could see a move towards the use of human placental vessels, perfused ex-vivo. However, further work is required to determine the feasibility and validity of this approach.

Summary
Recent advances in thrombus formation models have significantly improved the pathophysiological relevance of in-vitro flow chambers to better reflect the in-vivo environment and provide a more translational platform to test novel antithrombotics.
Impact of the COVID-19 Pandemic on the Management of Juvenile Idiopathic Arthritis: Analysis of United States Commercial Insurance Data
Authors: Horton Daniel B. , Yang Yiling , Neikirk Amanda , Huang Cecilia , Crystal Stephen , Davidow Amy , Haynes Kevin , Gerhard Tobias , Rose Carlos D. , Strom Brian L. , Parlett Lauren 
Published: October 2023

Background/Objective
Given limited information on health care and treatment utilization for juvenile idiopathic arthritis (JIA) during the pandemic, we studied JIA-related health care and treatment utilization in a commercially insured retrospective US cohort.

Methods
We studied rates of outpatient visits, new disease-modifying antirheumatic drug (DMARD) initiations, intra-articular glucocorticoid injections (iaGC), dispensed oral glucocorticoids and opioids, DMARD adherence, and DMARD discontinuation by quarter in March 2018–February 2021 (Q1 started in March). Incident rate ratios (IRR, pandemic vs prepandemic) with 95% confidence intervals (CIs) were estimated using multivariable Poisson or Quasi-Poisson models stratified by diagnosis recency (incident JIA, <12 months ago; prevalent JIA, ≥12 months ago).

Results
Among 1294 children diagnosed with JIA, total and in-person outpatient visits for JIA declined during the pandemic (IRR, 0.88–0.90), most markedly in Q1 2020. Telemedicine visits, while higher during the pandemic, declined from 21% (Q1) to 13% (Q4) in 2020 to 2021. During the pandemic, children with prevalent JIA, but not incident JIA, had lower usage of iaGC (IRR, 0.60; 95% CI, 0.34–1.07), oral glucocorticoids (IRR, 0.47; 95% CI, 0.33–0.67), and opioids (IRR, 0.44; 95% CI, 0.26–0.75). Adherence to and discontinuation of DMARDs was similar before and during the pandemic.

Conclusions
In the first year of the pandemic, visits for JIA dropped by 10% to 12% in commercially insured children in the United States, declines partly mitigated by use of telemedicine. Pandemic-related declines in intra-articular glucocorticoids, oral glucocorticoids, and opioids were observed for children with prevalent, but not incident, JIA. These changes may have important implications for disease control and quality of life.
Optimizing Facial Function in Patients With High-Risk Recurrent Pleomorphic Adenoma and a History of Facial Nerve Injury
Authors: Wen Y. Edward , Rozen Shai M. 
Published: October 2023

Background
Parotid pleomorphic adenoma (PA) patients present significant diagnostic and surgical challenges rendering them high risk for facial nerve injury. Recurrent PA patients often present with history of facial nerve injury or previous reanimations making salvage of the facial nerve or previous reanimations significantly more complex. The study aim is to share our experience with this high risk for facial nerve injury population and review the literature.

Methods
Adult patients with recurrent PA and history of facial nerve injury with at least 3 months of follow-up were analyzed for demographics, facial palsy history, previous head and neck surgeries, previous facial paralysis reconstruction, preoperative imaging, surgical approach, and postoperative outcomes.

Results
Four female patients were identified with an average age of 62 years. All patients underwent an initial protective dissection of the facial nerve or previous reanimation reconstruction by the facial nerve reconstructive team followed by the extirpative team. The average number of previous head and neck surgeries was 5, the number of recurrences was 2, and follow-up was 20 months. Half had prior dynamic facial reanimation. Two patients underwent complete preextirpative dissection of the facial nerve resulting in neuropraxia, which recovered completely after an average of 143 days. A third patient presented with 2 recurrences, both during and after reanimation with a dually innervated free functional muscle transfer. The reconstruction was salvaged, and motion was achieved. A fourth patient presented with benign preoperative findings, but intraoperative findings confirmed malignancy, necessitating facial nerve sacrifice, followed by immediate intratemporal grafting of the facial nerve and masseteric nerve transfer. Motion appeared 139 days postoperatively.

Conclusions
A multidisciplinary effort should be implemented in this high risk for facial nerve injury population with the primary goal of protecting the facial nerve or any previous reanimation procedures, yet with preparedness to apply any reconstructive strategy based on intraoperative findings.
Breast Implant–Associated Anaplastic Large Cell Lymphoma Awareness: An Analysis of the Responses to an Institutional Campaign and Global Recall
Authors: Mason Madeleine M. , Kuruoglu Doga , Zheng Eugene E. , Kerivan Lauren T. , Nguyen Minh-Doan T. 
Published: October 2023

Background
We performed an assessment of patient response rates and clinical outcomes to the global recall for textured breast implants and to our institution's letters informing them of their risk of breast implant–associated anaplastic large cell lymphoma (BIA-ALCL).

Methods
A retrospective review of patients who had textured implants placed at our institution was completed. Outcome measures included patient response rates to either the global recall or our institution's letters, rate of textured implant removal, and type of subsequent revision surgery.

Results
A total of 1176 patients with textured implants were reviewed for this study. In total, 374 patients (31.8%) reached out to discuss their risk of BIA-ALCL, and 297 (25.3%) eventually presented to the clinic. One hundred twenty eight patients (34.2%) responded after the letter but before the US Food and Drug Administration (FDA) ban of macrotextured BIOCELL implants, 186 (49.7%) after the FDA ban, and 48 (12.8%) after the manufacturer's multichannel campaign. One hundred eighteen patients with textured implants (11.6%) proceeded with surgery. Most underwent exchange with smooth implants (76 patients [64.4%]) after textured implant removal.

Conclusions
A significant portion of patients (31.8%) responded to our letters, the FDA ban, and the manufacturer's campaign. Despite the low incidence of BIA-ALCL and the ongoing recommendation for observation in the setting of no symptoms, 11.6% of our patients still elected to proceed with implant removal. Exchange to smooth implants was the most popular surgical option at 64.4%.
The emergence of super-resolution beyond the probe size in scanning 3DXRD microscopy
Authors: Kim Jaemyung , Hayashi Yujiro , Yabashi Makina 
Published: October 2023

The spatial resolution in scanning-based two-dimensional microscopy is normally limited by the size of the probe, thereby a smaller probe is a prerequisite for enhancing the spatial resolution. For three-dimensional microscopy that combines translation and rotation motions of a specimen, however, complex trajectories of the probe highly overlap in the specimen, which could change the postulate above. Here, the spatial resolution achieved in scanning three-dimensional X-ray diffraction (s3DXRD) microscopy is investigated. In this method, the most appropriate orientation of the pixel in the specimen coordinate is selected by comparing the completeness of diffraction peaks with theory. Therefore, the superposed area of the beam trajectory has a strong effect on the spatial resolution, in terms of the completeness of diffraction peaks. It was found that the highly superposed area by the incident X-rays, which has the highest completeness factor in the pixel of the specimen, is much smaller than the X-ray probe size, and that sub-pixel analysis by dividing a pixel into small pieces leads to drastic improvement of the spatial resolution in s3DXRD.
Designing a two-stage model for the resilient agri-food supply chain network under dynamic competition
Authors: Li Zhuyue , Zhang Chunxiao 
Published: October 2023

PurposeSupply chain risk management can effectively reduce the loss of retailers. In this regard, retailers need to consider the competition risks of competitors in addition to the disruption risks. This paper designs a resilient retail supply chain network for perishable foods under the dynamic competition to maximize retailer's profits.Design/methodology/approachA two-stage mixed-integer non-linear model is presented for designing the supply chain network. In the first stage, an equilibrium model that considers the characteristics of perishable foods is developed. In the second stage, a mixed integer non-linear programming model is presented to deal with the strategic decisions. Finally, an efficient memetic algorithm is designed to deal with large-scale problems.FindingsThe optimal the selection of suppliers, distribution centers and the order allocation are found among the supply chain entities. Considering the perishability of agri-food products, the equilibrium retail price and selling quantity are determined. Through a numerical example, the optimal inventory period under different maximum shelf life and the impact of three resilient strategies on retailer's profit, selling price and selling quantity are analyzed.Research limitations/implicationsAs for future research, the research can be extended in a number of directions. First, this paper studies the retail supply chain network design problem under competition among retailers. It can be an interesting direction to consider retailers competing with suppliers. Second, the authors can try to linearize the non-linear model and solve the large-scale integer programming problem by exact algorithm. Finally, the freshness of perishable foods gradually declines linearly to zero as the maximum shelf life approaches, and it would be a meaningful attempt to consider the freshness of perishable foods declines exponentially.Originality/valueThis paper innovatively designs the resilient supply chain network for perishable foods under dynamic competition. The retailer's dynamic competition and resilient strategies are considered simultaneously when designing supply chain network for perishable foods. In addition, this paper gives insights into how to obtain the optimal inventory period and compare the retailer's resilient strategies.
When cool hospitality brand meets AI: exploring the matching effect of service agents and brand images on brand attitude
Authors: Liu Yun , Wang Xingyuan , Qin Heyu 
Published: October 2023

Purpose
This paper aims to explore the matching effect of hospitality brand image (cool vs non-cool) and service agents (Artificial intelligence [AI] vs human staff) on brand attitude, with a focus on assessing the role of feeling right as a mediator and service failure as a moderator.

Design/methodology/approach
This paper tested the hypotheses through three experiments and a Supplementary Material experiment, which collectively involved 835 participants.

Findings
The results indicated that the adoption of AI by cool brands can foster the right feeling and enhance consumers’ positive brand attitudes. In contrast, employing human staff did not lead to improved brand attitudes toward non-cool brands. Furthermore, the study found that service failure moderated the matching effect between service agents and cool brand images on brand attitude. The matching effect was observed under successful service conditions, but it disappeared when service failure occurred.

Practical implications
The findings offer practical guidance for hospitality companies in choosing service agents based on brand image. Cool brands can swiftly transition to AI, reinforcing their modern, cutting-edge image. Traditional brands may delay AI adoption or integrate it strategically with human staff.

Originality/value
To the best of the authors’ knowledge, this paper represents one of the first studies to address the issue of selecting the optimal service agent based on hospitality brand image. More importantly, it introduces the concept of a cool hospitality brand image as a boundary condition in the framework of AI research, providing novel insights into consumers’ ambivalent responses to AI observed in previous studies.
Bioinformatic investigation of Nipah virus surface protein mutations: Molecular docking with Ephrin B2 receptor, molecular dynamics simulation, and structural impact analysis
Authors: Aktaş Emre , Saygılı İrem , Kahveci Elif , Tekbıyık Zeynep , Özgentürk Nehir Özdemir 
Published: October 2023

AbstractThe SARS‐CoV‐2 outbreak resulted in significant challenges and loss of life. The Nipah virus, known for its high infectivity and severity, was designated an emergency concern by the World Health Organization. To understand its mutations, the Nipah virus proteins were analyzed extensively, with a focus on the essential G and F proteins responsible for viral entry into host cells. Our bioinformatics analysis unveiled multiple mutations, including simultaneous mutations within a single sequence. Notably, the G273S mutation in the F protein was identified as a potential cause of structural damage, which carries significant implications for vaccine development. Comparing the docking scores of G and F proteins with the Ephrin B2 receptor, it was found that the Y228H mutation in the G protein and the D252G mutation in the F protein likely affect virus entry into host cells. Moreover, our investigation into stability and deformability highlighted the impact of the Y228H mutation in the G protein complex. Molecular dynamics simulations revealed increased flexibility and conformational changes in the G protein complex with the Y228H mutation compared with the known complex. Furthermore, evaluating the root mean square deviation variation demonstrated greater dynamic behavior in the G protein complex and the Ephrin B2 receptor complex. This comprehensive study provides valuable insights into Nipah virus mutations, their significance for vaccine development, and the importance of understanding protein complex behavior in drug discovery. The identified mutations, especially G273S and Y228H, hold crucial implications for future research and potential interventions against the Nipah virus.
Effect of climate change‐induced increases on the range of rice‐barley double cultivation on the intermediate egret
Authors: Choi Green , Son Seok‐Jun , Do Min Seock , Nam Hyung‐Kyu 
Published: October 2023

Abstract

Intensification of cultivation methods and land‐use types, particularly in the face of climate change, has steadily weakened the habitat function of rice fields for waterbirds.

Intermediate egrets (Ardea intermedia) are highly dependent on rice field habitats. Here, we examine the effect of a shift from rice monoculture to rice–barley double cultivation on the use of rice fields by intermediate egrets in South Korea. Rice–barley double cultivation has been increasing steadily in the southern region of South Korea due to changes in the rice growth period under climate change and maximization of economic benefits.

We studied rice fields to determine the effect of the rice–barley double cultivation area on the abundance of intermediate egrets on the regional scale and their potential distribution pattern in response to double cultivation in relation to climate change using national‐scale climate, altitude and land cover data from 1 May to 23 June 2018.

Compared to the irrigation practices used for rice monoculture, irrigation was stopped for some time in rice–barley double cultivation prior to planting, compromising the role of rice fields as a food ground for intermediate egrets. The potential abundance of intermediate egrets rapidly decreased by half when the double cultivation area increased to >40% of the total rice‐field area, and was less than one individual if the area increased to >80%. Furthermore, according to climate change projections, by 2100, the double cultivation area would account for 75.74% of the predicted range of intermediate egret foraging ground.

Synthesis and applications. Double cultivation areas should be <40% of existing rice fields to minimize the impact of the change in cultivation practices. This approach can also convert rice fields to other types of land use. Consequently, appropriate conservation and management measures may be developed to maintain suitable habitats despite rapidly changing cultivation practices resulting from climate change.