bluuebunny/crossref_metadata_2025_split huggingface dataset:
Physiologically‐based pharmacokinetic model to predict doxorubicin and paclitaxel exposure in infants through breast milk
Authors: Damoiseaux David , Amant Frédéric , Beijnen Jos H. , Barnett Shelby , Veal Gareth J. , Huitema Alwin D. R. , Dorlo Thomas P. C. 
Published: October 2023

AbstractLimited information is available concerning infant exposure and safety when breastfed by mothers receiving chemotherapy. Whereas defining distribution to breast milk is important to infer drug exposure, infant pharmacokinetics also determine to what extent the infant will be exposed to potential toxic effects. We aimed to assess the impact of chemotherapy containing breast milk on infants by predicting systemic and local (intestinal) exposure of paclitaxel and doxorubicin in infants through breast milk using a physiologically‐based pharmacokinetic (PBPK) approach. Whole‐body PBPK models of i.v. paclitaxel and doxorubicin were extended from the literature, with an oral absorption component to enable predictions in infants receiving paclitaxel or doxorubicin‐containing breast milk. For safety considerations, worst‐case scenarios were explored. Finally, paclitaxel and doxorubicin exposures in plasma and intestinal tissue of infants following feeding of breast milk from paclitaxel‐ or doxorubicin‐treated mothers were simulated and breast milk discarding strategies were evaluated. The upper 95th percentile of the predicted peak concentrations in peripheral venous blood were 3.48 and 0.74 nM (0.4%–1.7% and 0.1%–1.8% of on‐treatment) for paclitaxel and doxorubicin, respectively. Intestinal exposure reached peak concentrations of 1.0 and 140 μM for paclitaxel and doxorubicin, respectively. Discarding breast milk for the first 3 days after maternal chemotherapy administration reduced systemic and tissue exposures even further, to over 90% and 80% for paclitaxel and doxorubicin, respectively. PBPK simulations of chemotherapy exposure in infants after breastfeeding with chemotherapy containing breast milk suggest that particularly local gastrointestinal adverse events should be monitored, whereas systemic adverse events are not expected.
Microfluidic Printing of Vertically‐Oriented Nanosheets/MOFs Hetero‐Interface for Intensive Pseudocapacitive Storage
Authors: Yu Xude , Liu Hengyuan , Ling Sida , Wu Xingjiang , Lian Cheng , Xu Jianhong 
Published: October 2023

AbstractEfficient manufacture of electroactive vertically‐oriented nanosheets with enhanced electrolyte mass diffusion and strong interfacial redox dynamics is critical for realizing high energy density of miniature supercapacitor (SC), but still challenging. Herein, microfluidic droplet printing is developed to controllably construct vertically‐oriented graphene/ZIF‐67 hetero‐microsphere (VAGS/ZIF‐67), where the ZIF‐67 is coordinately grown on vertically‐oriented graphene framework via Co─O─C bonds. The VAGS/ZIF‐67 shows ordered porous channel, high electroactivity and strong interfacial interaction, providing rapid electrolyte diffusion dynamics and high faradaic capacitance in KOH solution (1674 F g−1, 1004 C g−1), which are verified by computational fluid dynamics (CFD) and density functional theory (DFT). Moreover, the VAGS/ZIF‐67 based SC exhibits large energy density (100 Wh kg−1), excellent durability (10 000 cycles and high/low temperature), and robust power‐supply applications in portable electronics.
Single Multifunctional Nanocabinets‐Based Target‐Activated Feedback for Simultaneously Precise Monitoring and Therapy
Authors: Li Binxiao , Lu Yanwei , Huang Xuedong , Ning Yujun , Shi Qian , Liu Jianwei , Liu Baohong 
Published: October 2023

AbstractStimulus‐responsive mode is highly desirable for improving the precise monitoring and physiological efficacy of endogenous biomarkers (EB). However, its integrated application for visual detection and therapy is limited by inappropriate use of responsive triggers and poor delivery of EB signal‐transducing agents, which remain challenging in simultaneous monitoring and noninvasive therapy of EB and EB‐mediated pathological events. Target microRNA (miRNA) as controllable reaction triggers and DNAzyme as signal‐transducing agent are proposed to develop target‐stimulated multifunctional nanocabinets (MFNCs) for the visual tracking of both miRNA and miRNA‐mediated anticancer events. The MFNCs, equipped with a target‐discriminating sequence‐incorporated DNAzyme motif, can specifically release therapeutic molecules through target‐triggered conformational switches, accompanied by transduction signal output. Target detection and molecule release performance are recorded in parallel via reverse dual‐signal feedback at the single‐molecule level. In addition, the intrinsic thermal‐replenishing of the MFNCs leads to tumor ablation without invasive exogenous aids. The system achieves visual target quantification, anticancer molecule real‐time tracking, and tumor suppression in vivo and in vitro. This work proposes a new paradigm for precise visual exploration of EB or EB‐mediated bio‐events and provides a demonstration of efficacious all‐in‐one detection and therapy based on the target‐triggered multifunctional nanosystem.
Improving fault localization via weighted execution graph and graph attention network
Authors: Yan Yue , Jiang Shujuan , Zhang Yanmei , Zhang Cheng 
Published: October 2023

AbstractSoftware fault localization is commonly recognized as arduous and time consuming. Spectrum‐based fault localization (SBFL) has been widely used due to its lightness. However, the effectiveness of SBFL is limited since it only considers simple statistics on the coverage information, ignoring the tie problem that the spectrum matrixes of some statements are the same. Most existing deep learning‐based fault localization (DLFL) techniques convert the coverage information into a vector, which utilizes the spectrum in a simplified manner and still has limitations in practice. To solve the above problem, we propose an approach via the weighted execution graph and graph attention network (WEGAT). We use a graph structure to represent the coverage information between test cases and program elements. Then, we generate a weighted execution graph by applying the predicate execution sequence. Furthermore, we combine the weighted execution graph with the AST as an integrated graph, which is the input of the GAT for fault localization. We evaluate WEGAT in within‐project and cross‐project prediction scenarios on the Defects4J benchmark. Experimental results show that our approach outperforms traditional SBFL (Ochiai, DStar and Tarantula) and DLFL (TraPT, CNN‐FL, Grace, and AGFL) methods, effectively improving the accuracy of fault localization.
Mass ratio factor in control performance of optimum tuned liquid dampers
Authors: Ocak Ayla , Bekdaş Gebrail , Nigdeli Sinan Melih 
Published: October 2023

SummaryTuned liquid dampers provide structure control with the help of the liquid mass in tanks that are attached to the structure. The mass ratio affects the optimum tuned liquid damper (TLD) parameters. This study examines the effect of mass ratio on the control performance of TLD devices in providing seismic control of structures with different damping ratios. For this purpose, TLD devices with different mass ratios were placed on two different single‐story steel and reinforced concrete structure models, and their performance under earthquake excitation was investigated. TLD parameters for obtaining the optimum displacement level in the 0.5‐ and 1.0‐s structure natural period for both structure types were optimized with the Jaya algorithm (JA), which is a metaheuristic algorithm. By using the optimum TLD parameters, the structural displacement and total acceleration values were obtained by the critical earthquake analysis. When the results are examined, it is understood that TLD mass increase from a 20% mass ratio for both structure types and selected structure periods does not have a significant effect on TLD control performance.
Partnering for Success: Text and Peer Engagement During Paired Reading
Authors: Roberts Kathryn L. , Arya Poonam , Plond Kathleen K. 
Published: October 2023

AbstractIn this article we report the results and classroom implications of a qualitative study that explored third‐grade students' interactions with each other as they partner read. Participants included 10 students, each of whom engaged in three readings with a partner during recorded observations. All students had been taught structures for partner reading and numerous reading strategies by their classroom teacher. The transcripts of the readings were parsed, annotated with observational notes, and coded using descriptive phrases. Students' interactions with each other during the readings revealed that they are capable of productively using their time to support learning during partner reading and spend relatively little time off task and that their use of strategies varies with context (text interest, text difficulty, turn‐taking patterns). Classroom implications for these findings are discussed.
NMR spectroscopic investigations on the successive implementation of nickel and zinc ions to a NacNac‐dibenzofuran‐Br ligand precursor
Authors: Krause Konstantin B. , Cula Beatrice , Dallmann André , Limberg Christian 
Published: October 2023

AbstractThe ligand precursor HNacNac‐dibenzofuran‐Br, LH, was synthesized by the condensation of 6‐bromo‐4‐dibenzofuranamine and 4‐(N‐(mesityl)amino)pent‐3‐en‐2‐one with the aim of preparing heterodinuclear nickel/zinc complexes in two successive steps. Reacting LH with Zn(HMDS)2, Zn(C6F5)2 and Zn(C2H5)2 led to the respective X‐Zn‐NacNac‐dibenzofuran‐Br complexes (X=HMDS (2), C6F5 (3), Et (4)). However, in case of 2 and 3 the subsequent treatment with Ni(COD)2/TMEDA did not lead to any conversion, probably as the steric bulk imposed by the NacNac‐Zn‐X entities was too high. 4 did react with Ni(COD)2/TMEDA, likely in the envisaged manner, but apparently the targeted product complex Et‐Zn‐NacNac‐dibenzofuran‐Ni(TMEDA)Br, once formed, immediately reacts further via a Negishi coupling reaction, so that Br‐Zn‐NacNac‐dibenzofuran‐Et (5) is formed. The reaction of 4 with triethylammonium bromide led to the formation of the Br‐Zn‐NacNac‐dibenzofuran‐Br (6) complex that could be reacted with Ni(COD)2/TMEDA successfully. All attempts to purify the product led to Zn(NacNac‐dibenzofuran‐Ni(TMEDA)Br)2, which is insoluble in THF and thus drives a dismutation reaction.
Identification of Causal Chains for Sustainable Tourism Development Within Two Chilean Patagonia National Parks: Cerro Castillo and Torres del Paine
Authors: Adiego Andrés , Vela-Ruiz Figueroa Germaynee , Repetto Giavelli Fiorella , Gale-Detrich Trace 
Published: October 2023

AbstractThe Austral Macrozone of ChileanPatagonia (Aysén and Magallanes Regions) is home to 80% of the total area of the 106 protected areas (PAs) of the National System of Wildlife Protected Areas (SNASPE), and many of its PAs are experiencing intense socio-environmental challenges related to the balance between effective conservation and growing tourism development, in the face of uncertainty and change. This chapter takes an in-depth look at the causal chains for sustainable tourism development within the Cerro Castillo and Torres del Paine National Parks, using Ante Mandić’s (Environ Syst Decis 40(4):560–576, 2020) conception of the Drivers, Pressures, State, Impact, and Response (DPSIR) model for advancing the sustainability of PAs that are managing nature-based tourism growth. Outcomes of the study represent an important first step for developing a better understanding of the causal chains related to the economic, social, and environmental dynamics of tourism in PAs within Chilean Patagonia and validate the value of moving forward with Mandić’s (Environ Syst Decis 40(4):560–576, 2020) to advance understanding of tourism’s effects on their conservation and management and thus, improve their potential for sustainability.
Visual Dimensions of Conservation Landscapes: An Exploration of Patagonian Fjordic Landscapes from the Perspective of Prospective Chilean Tourists
Authors: Báez Montenegro Andrea , Gale-Detrich Trace , Rodríguez Laura 
Published: October 2023

AbstractThis chapter explores Chilean tourists’ valuation of tourism experiences in and around the Chilean village of Puyuhuapi. In 2020, local stakeholders were concerned about the impacts that salmon aquaculture infrastructure within the fjords surrounding Puyuhuapi might have on tourism. Research was undertaken to examine how prospective national tourists might perceive visible salmon aquaculture infrastructure within Puyuhuapi’s landscapes. Two hypothetical experience scenarios were designed, with short texts describing possible experiences and visual cues portraying typical destination landscapes. The scenarios were differentiated by the presence of movable floating sea cages. The scenarios were presented to potential tourists through an online survey (n = 804 responses). Results supported current nature-based tourism experience positioning, suggesting it was well received with and without the presence of salmon aquaculture infrastructure. The visible presence of the movable floating sea cages did not provoke significant differences in the valuation of the landscape for prospective tourists; nevertheless, several significant interactions occurred between tourism experience attributes and socio-demographic characteristics, including population density, level of education, and sex. Discussion focuses on defining a series of hypotheses to inform future research and the importance of expanding understanding of Chilean perspectives and imaginaries of Patagonia and its abundant natural settings and values.
Superstrings on Penrose limits of AdS7 solutions
Authors: Passias Achilleas 
Published: October 2023

Abstract
We consider the Penrose limit of AdS7 solutions of massive Type IIA supergravity. The resulting pp-wave geometry is supported by RR and NSNS fields. We quantize the Green-Schwarz superstring on the obtained pp-wave background, in the light-cone gauge.
Next-to-leading order electroweak corrections to gg → HH and gg → gH in the large-mt limit
Authors: Davies Joshua , Schönwald Kay , Steinhauser Matthias , Zhang Hantian 
Published: October 2023

Abstract
We compute two-loop electroweak corrections to Higgs boson pair and Higgs plus jet production, taking into account all sectors of the Standard Model. All diagrams with virtual top quarks are computed in an expansion for large top quark mass up to order 1/$$ {m}_t^8 $$

m
t
8

or more. We present analytic results for the form factors and discuss the convergence properties. For the process gg → gH we also consider QCD corrections in the large-mt limit.
Factors driving dispersal and habitat use of loggerhead sea turtle post-hatchlings and its conservational implications
Authors: Abalo-Morla Sara , Muñoz-Mas Rafael , Tomás Jesús , Belda Eduardo J. 
Published: October 2023

AbstractNesting events of loggerhead sea turtles (Caretta caretta) are on the rise in the Western Mediterranean Sea, far from their usual nesting areas in the Mediterranean and Atlantic basins. The study of dispersal behavior toward potential developmental areas of loggerhead post-hatchlings from this new nesting area is crucial to comprehend this colonization process and determining grounded conservation strategies. To fill this gap, we investigated, for the first time in the Mediterranean Sea, the dispersal strategies and habitat use based on data from 19 head-started loggerhead post-hatchlings released from the Spanish Mediterranean coast and satellite-tracked between 2016 and 2018. Turtles dispersed over large areas and showed active swimming phases, as they frequently dispersed against sea currents. Dispersal routes varied for each individual, although they consistently dispersed south-eastwards, especially during the coldest periods. Several post-hatchlings traveled through the Sicilian Channel to reach deep and warmer areas in the eastern Mediterranean basin. The most year-round suitable areas corresponded to the Ionian and Levantine Seas, which correspond with those found in their traditional nesting areas. Therefore, conservation measures focused on this stage should be taken in the path toward and these developmental areas.
Vom Gegenwartsmoment zur Gegenwartsgestalt
Authors: Plassmann Reinhard 
Published: October 2023

ZusammenfassungDie Arbeit beschreibt, dass aktives emotionales Material in der Stunde Gegenwartsmomente erzeugt. Diese Gegenwartsmomente sind dann nicht Einzelereignisse, sondern bilden ein zunächst unbewusstes Narrativ, eine Gegenwartsgestalt. Sie hat den Charakter einer Erzählung über aktuelles emotionales Geschehen, über unbewusstes emotionales Übertragungsmaterial und über die infantile Vorgeschichte. Gegenwartsmoment und Gegenwartsgestalt enthalten in großer Deutlichkeit auch emotionale Wahrnehmungen von Zuständen und Vorgängen im eigenen Selbst. Dieser Typ von Emotionen, der bislang wenig Beachtung fand, kann nach dem Vorschlag des Autors Selbstemotion genannt werden. Aufgabe von prozessbezogenen Deutungen kann es dann sein, mit den Patientinnen und Patienten zunächst das Präsentwerden des emotionalen Materials, was in Gegenwartsmoment und Gegenwartsgestalt in die Stunde kommt, zu benennen. Daran schließt sich die Aufgabe an, mit dem in die Gegenwartsgestalt eingewobenen emotionalen Narrativ inhaltlich zu arbeiten, also die Prozesse von Regulation, Integration und Bewusstsein zu unterstützen. Dadurch können sich dissoziative Risse im Selbst schließen.
Comparative efficacy of ultrasound guidance and fluoroscopy or computed tomography guidance in spinal nerve injections: a systematic review and meta-analysis
Authors: Kimura Ryota , Yamamoto Norio , Watanabe Jun , Ono Yuichi , Hongo Michio , Miyakoshi Naohisa 
Published: October 2023

Abstract
Purpose
Spinal nerve injections have traditionally been performed under fluoroscopic (FL) and computed tomography (CT) guidance. Recently, ultrasound (US)-guided procedures have provided an alternative guidance approach that does not expose the patient and operator to radiation. The aim of this study was to compare the efficacy and safety of US-guided spinal nerve injections compared with FL- or CT-guided spinal nerve injections.

Methods
MEDLINE, Cochrane Library, EMBASE, international clinical trials registry platform (ICTRP) and ClinicalTrials.gov database searches for inclusion until February 2023 were independently performed by two authors using predefined criteria. Randomized controlled trials (RCTs) were included. Primary outcomes were change in pain score (numeric rating scale or visual analogue scale) and major adverse events. Secondary outcomes were procedure time, change in functional disability score and minor adverse events. Meta-analysis was performed using random-effect model. We evaluated the certainty of evidence based on the Grading of Recommendations, Assessment and Development (GRADE) approach.

Results
Eight RCTs involving 962 patients were included. There might be little to no difference in the mean score of the pain change between the US-guided methods and the FL- or CT-guided injections (standard mean difference -0.06; 95% confidence interval [CI] −0.26 to 0.15). US guidance probably reduced major adverse events (0.7% [3/433] and 6.5% [28/433], respectively), reduced procedure time (mean difference −4.19 min; 95% CI −5.09 to −3.30), and probably reduced minor adverse events (2.1% [9/433] and 4.2% [18/433], respectively) compared with FL or CT guidance. There was probably little to no difference in the change in functional disability score with either method.

Conclusion
US-guided spinal nerve injections remained effective and reduced adverse events compared with conventional FL- or CT-guided spinal nerve injections. Further RCTs are required to verify our results.

Study registration
Open Science Forum (Available from: https://osf.io/vt92w/).
Bear trade in Poland: an analysis of legal and illegal international trade from 2000 to 2021
Authors: Gomez Lalita , Kala Borys , Shepherd Chris R. 
Published: October 2023

AbstractCommercial trade is one of the leading threats to bears as they are targeted for trophies, food and medicines. While the threat from illegal trade and trafficking has been extensively studied in Asia, understanding of bear trade dynamics outside this region is limited. Poland is an end use destination for wildlife products such as trophies and wildlife-based traditional medicines. To gain an understanding of the bear trade in Poland, we conducted an analysis of (1) seizure data, (2) Convention on International Trade in Endangered Species of Wild Fauna and Flora (CITES) trade data and (3) online surveys of Polish websites. We found that the trade of bears in Poland predominantly involves a demand for traditional bear-based medicines and, to a lesser extent, trophies. While trade in bear-based medicines and trophies is permissible with appropriate permits, illegal trade in such commodities is occurring in violation of CITES and European Union Wildlife Trade Regulations and in case of brown bear specimens—also national laws. This may possibly be due to a lack of public awareness regarding laws governing the import and export of bear parts and derivatives in which case education and awareness raising programmes might prove beneficial in eradicating trafficking of bear-based medicines and trophies. The use of bear bile for traditional medicine in Eastern Europe has not been previously documented and merits further research as to its scale, the source of bears used for these purposes and the potential impacts to bear populations.
Das zitternde Herz des Monarchen – Hintergründe zum Herzleiden von Kaiser Maximilian II
Authors: Heusinger Tobias , Stolberg Michael 
Published: October 2023

ZusammenfassungEs ist in der Geschichtsforschung seit Langem bekannt, dass der Habsburger Kaiser Maximilian II (1527–1576) zeitlebens unter Herzbeschwerden litt. Zahlreiche Biografen erwähnen diesen Umstand. Seine Krankengeschichte und selbst die Ergebnisse der Obduktion seiner Leiche sind überliefert. Nur unzureichend untersucht ist dagegen, wie Maximilians Ärzte dessen häufig als „Herzzittern“, „tremor cordis“ bezeichnetes Herzleiden erklärten, welche Ursachen und Auslöser sie für die Beschwerden verantwortlich machten, im Allgemeinen und im konkreten Fall ihres berühmten Patienten. Der vorliegende Beitrag geht diese Fragen an, primär anhand eines ausführlichen Konsils des kaiserlichen Leibarztes Andrea Gallo aus dem Jahr 1555. Dieses bislang von der Forschung ignorierte Konsil fasst zunächst das damalige „Lehrbuchwissen“ zum Herzzittern zusammen. Im Anschluss daran wendet es sich dem Fall Maximilians zu und eröffnet dabei nicht zuletzt aufschlussreiche Einblicke in dessen seelische Befindlichkeit.