bluuebunny/crossref_metadata_2025_split huggingface dataset:
A comprehensive narrative review of challenges and facilitators in the implementation of various HPV vaccination program worldwide
Authors: Aggarwal Sumit , Agarwal Pragati , Gupta Nivedita 
Published: January 2024

AbstractIntroductionCervical cancer has been considered as one of the most common cancers in women (15–44 years) globally, but the advent of the human papilloma virus (HPV) vaccine has raised the anticipation that eradication of cervical carcinoma might be achieved in the near future as several prophylactic cervical carcinoma vaccines have already been currently licensed in various countries. Countries should devise strategies, practices and policies to attain and sustain higher levels of HPV immunization coverage as still 68% countries have introduced HPV vaccine in their national immunization programs even after 17 years following the licensure of the first prophylactic HPV vaccine.MethodologyA comprehensive literature analysis was conducted using various databases and search engines, to include the most relevant research articles and data available and critically discussed the operational gaps that need to be answered to achieve adequate coverage of HPV vaccination.ResultsThe present review highlights the existing HPV vaccination strategies, unmet needs and challenges needed to be addressed for proper implementation framework as well as the collaborations required to achieve decent vaccination coverage. Well‐coordinated vaccination strategy with focus on adolescent girls and if possible, boys can lead to dramatic impact on disease reduction around the world.
Examining hypertension risk among Black and White breast cancer survivors
Authors: Sutton Arnethea L. , He Jian , Bottinor Wendy , Hong Susan , Mitchell Kristyn , Hines Anika L. 
Published: January 2024

AbstractPurposeBreast cancer survivors are at increased risk of cardiovascular dysfunction following their diagnosis; however, hypertension remains underexplored within this context. This retrospective cohort study examined the incidence of hypertension in breast cancer survivors and the association of race with hypertension risk among them.MethodsData for this study were abstracted from the electronic health records of women diagnosed with Stages I–III breast cancer. Incident hypertension diagnosis was identified through International Classification of Diseases codes. Bivariate associations were tested using Student's t‐test and chi‐squared test of independence. Bivariable Cox regression analysis was used to determine demographic and clinical factors that may have been associated with the development of hypertension.ResultsA total of 664 women were included. Most women were 50 years of age or younger (52.0%), White (33.0% Black), and received a mastectomy (80.6%). Overall, 45.5% of the cohort developed hypertension. The 1‐year hypertension‐free survival estimates were 47% (95% confidence interval [CI], 41–54) in Black women and 73% (95% CI, 69–77) in White women (p < 0.0001). Besides race, statistically significant predictors of hypertension included: age greater than 50 (vs. ≤50) (adjusted Hazard Ratio [HR]: 1.40; 95% CI, 1.09–1.80) and residing in a non‐metropolitan area (vs. metropolitan) (adjusted HR: 1.60; 95% CI, 1.19–2.16).ConclusionsThis study suggests that breast cancer survivors who are older, Black, or residing in non‐metropolitan areas may benefit from added surveillance and hypertension prevention strategies during treatment. Future studies are needed to identify contributors to the observed racial and geographic disparities.
Symmetrically dotted tympanic membranes
Authors: Seifen Christopher , Helling Kai 
Published: January 2024

Key Clinical MessageColor changes of the tympanic membranes without an inflammatory component or perforation are rarely described. They may result from hemorrhage after barotrauma or spontaneously. Other explanatory models include discoloration due to otomycosis.AbstractThis is a case of a 61‐year‐old patient with an unexplained incidental of black dots located almost symmetrically on the antero‐inferior quadrant of both tympanic membranes. This harmless anatomical rarity has not been published before. Underlying pathologies should be excluded in the case of discoloration of the tympanic membranes.
Epoxide‐Mediated Trans‐Thioglycosylation and Application to the Synthesis of Oligosaccharides Related to the Capsular Polysaccharides of C. jejuni HS:4
Authors: Homayonia Saba , Ling Chang‐Chun 
Published: January 2024

AbstractThe enzyme‐resistant thioglycosides are highly valuable immunogens because of their enhanced metabolic stability. We report the first synthesis of a family of thiooligosaccharides related to the capsular polysaccharides (CPS) of Campylobacter jejuni HS:4 for potential use in conjugate vaccines. The native CPS structures of the pathogen consist of a challenging repeating disaccharide formed with β(1→4)‐linked 6‐deoxy‐β‐D‐ido‐heptopyranoside and N‐acetyl‐D‐glucosamine; the rare 6‐deoxy‐ido‐heptopyranosyl backbone and β‐anomeric configuration of the former monosaccharide makes the synthesis of this family of antigens very challenging. So far, no synthesis of the thioanalogs of the CPS antigens have been reported. The unprecedented synthesis presented in this work is built on an elegant approach by using β‐glycosylthiolate as a glycosyl donor to open the 2,3‐epoxide functionality of pre‐designed 6‐deoxy‐β‐D‐talo‐heptopyranosides. Our results illustrated that this key trans‐thioglycosylation can be designed in a modular and regio and stereo‐selective manner. Built on the success of this novel approach, we succeeded the synthesis of a family of thiooligosaccharides including a thiohexasaccharide which is considered to be the desired antigen length and complexity for immunizations. We also report the first direct conversion of base‐stable but acid‐labile 2‐trimethylsilylethyl glycosides to glycosyl‐1‐thioacetates in a one‐pot manner.
Regioselective Partial Hydrogenation and Deuteration of Tetracyclic (Hetero)aromatic Systems Using a Simple Heterogeneous Catalyst
Authors: Kehoe Roberta A. , Lowry Amy , Light Mark E. , Jones David J. , Byrne Peter A. , McGlacken Gerard P. 
Published: January 2024

AbstractThe introduction of added ‘3‐dimensionality’ through late‐stage functionalisation of extended (hetero)aromatic systems is a powerful synthetic approach. The abundance of starting materials and cross‐coupling methodologies to access the precursors allows for highly diverse products. Subsequent selective partial reduction can alter the core structure in a manner of interest to medicinal chemists. Herein, we describe the precise, partial reduction of multicyclic heteroaromatic systems using a simple heterogeneous catalyst. The approach can be extended to introduce deuterium (again at late‐stage). Excellent yields can be obtained using simple reaction conditions.
Inhibition of polymorphic MexXY‐OprM efflux system in Pseudomonas aeruginosa clinical isolates by Berberine derivatives
Authors: Giorgini Giorgia , Di Gregorio Alessandra , Mangiaterra Gianmarco , Cedraro Nicholas , Minnelli Cristina , Sabbatini Giulia , Mobbili Giovanna , Simoni Serena , Vignaroli Carla , Galeazzi Roberta 
Published: January 2024

AbstractThe MexXY‐OprM multidrug efflux pump (EP) in aminoglycosides resistant Pseudomonas aeruginosa is one of the major resistance mechanisms, which is often overexpressed in strains isolated from pulmonary chronic disease such as cystic fibrosis.[1–3] In this research, we focused on the design of potential efflux pumps inhibitors, targeting MexY, the inner membrane component, in an allosteric site. Berberine[4] has been considered as lead molecule since we previously demonstrated its effectiveness in targeting MexY in laboratory reference strains.[5,6] Since this protein is often present in polymorphic variants in clinical strains, we sequenced and modeled all the mutated forms and we synthesized and evaluated by computational techniques, some berberine derivatives carrying an aromatic functionalization in its 13‐C ring position. These compounds were tested in vitro against clinical P. aeruginosa strains for antimicrobial and antibiofilm activity. In conclusion, the results demonstrated the importance of the aromatic moiety functionalization in exerting the EP inhibitory activity in synergy with the aminoglycoside tobramycin. More, we found that aminoacidic composition of MexY in different strains must be considered for predicting potential binding site and affects the different activity of berberine derivatives. Finally, the antibiofilm effect of these new EPIs is promising, particularly for o‐CH3‐berberine derivative.
Transition metal dichalcogenide‐based materials for rechargeable aluminum‐ion batteries: A mini‐review
Authors: Nandi Sunny , Pumera Martin 
Published: January 2024

AbstractRechargeable aluminum‐ion batteries (AIBs) have emerged as a promising candidate for energy storage applications and have been extensively investigated over the past few years. Due to their high theoretical capacity, nature of abundance, and high safety, AIBs can be considered an alternative to lithium‐ion batteries. However, the electrochemical performance of AIBs for large‐scale applications is still limited due to the poor selection of cathode materials. Transition metal dichalcogenides (TMDs) have been regarded as appropriate cathode materials for AIBs due to their wide layer spacing, large surface area, and distinct physiochemical characteristics. This mini‐review provides a succinct summary of recent research progress on TMD‐based cathode materials in non‐aqueous AIBs. The latest developments in the benefits of utilizing 3D‐printed electrodes for AIBs are also explored.
Mechanistic Analysis Reveals Key Role of Interchalcogen Multicatalysis in Photo‐Aerobic 3‐Pyrroline Syntheses by Aza‐Wacker Cyclizations
Authors: Graf Sebastian , Pesch Henner , Appleson Theresa , Lei Tao , Breder Alexander , Siewert Inke 
Published: January 2024

AbstractA light‐driven dual and ternary catalytic aza‐Wacker protocol for the construction of 3‐pyrrolines by partially disulfide‐assisted selenium‐π‐acid multicatalysis is reported. A structurally diverse array of sulfonamides possessing homopolar mono‐, di‐ and trisubstituted olefinic double bonds is selectively converted to the corresponding 3‐pyrrolines in up to 95 % isolated yield and with good functional group tolerance. Advanced electrochemical mechanistic investigations of the protocol suggest a dual role of the disulfide co‐catalyst. On the one hand, the disulfide serves as an electron hole shuttle between the excited photoredox catalyst and the selenium co‐catalyst. On the other hand, the sulfur species engages in the final, product releasing step of the catalytic cycle by accelerating the β‐elimination of the selenium moiety, which was found in many cases to lead to considerably improved product yields.
The “In situ electrolyte” as a sustainable alternative for the realization of high‐power devices
Authors: Sander Miriam , Magar Sandesh Darlami , Etter Martin , Balducci Andrea , Borchardt Lars 
Published: January 2024

AbstractThe “in situ electrolyte” displays a concept for electric double‐layer‐ as well as metal‐ion capacitors in which the by‐products formed during carbon synthesis serve directly as electrolyte salt to minimize waste. In this work, the concept is applied for lithium‐ and sodium‐based systems realizing EDLCs containing aqueous, “Water in Salt” (up to 1.8 V) as well as organic (2.4 V) electrolytes. Via the mechanochemical synthesis, carbon materials with surface areas up to 2000 m2 g−1 and an optimal amount of remaining by‐product are designed from the renewable resource lignin. Different cation‐anion combinations are enabled by further modification directly inside the pores creating imide‐based salts which are tracked by synchrotron in situ XRD. By the addition of solvents, the EDLCs show good capacitances up to 21 F g−1 combined with excellent rate performances and stabilities. Moreover, the LiTFSI loaded carbon as positive electrode introduces a new tunable lithium alternative for the pre‐lithiation of Li‐ion capacitors displaying a good rate performance and cyclability.
A test of the frost wave hypothesis in a temperate ungulate
Authors: Ortega Anna C. , Merkle Jerod A. , Sawyer Hall , Monteith Kevin L. , Lionberger Patrick , Valdez Miguel , Kauffman Matthew J. 
Published: January 2024

AbstractGrowing evidence supports the hypothesis that temperate herbivores surf the green wave of emerging plants during spring migration. Despite the importance of autumn migration, few studies have conceptualized resource tracking of temperate herbivores during this critical season. We adapted the frost wave hypothesis (FWH), which posits that animals pace their autumn migration to reduce exposure to snow but increase acquisition of forage. We tested the FWH in a population of mule deer in Wyoming, USA by tracking the autumn migrations of n = 163 mule deer that moved 15–288 km from summer to winter range. Migrating deer experienced similar amounts of snow but 1.4–2.1 times more residual forage than if they had naïve knowledge of when or how fast to migrate. Importantly, deer balanced exposure to snow and forage in a spatial manner. At the fine scale, deer avoided snow near their mountainous summer ranges and became more risk prone to snow near winter range. Aligning with their higher tolerance of snow and lingering behavior to acquire residual forage, deer increased stopover use by 1 ± 1 day (95% CI) day for every 10% of their migration completed. Our findings support the prediction that mule deer pace their autumn migration with the onset of snow and residual forage, but refine the FWH to include movement behavior en route that is spatially dynamic.
Neighbourhood socioeconomic status and pain among older adults—A cross‐sectional study
Authors: Okuyama Kenta , Johansson Sven‐Erik , Sundquist Kristina 
Published: January 2024

AbstractBackgroundPain is associated with falls, disability and a poor quality of life among older adults. It is highly prevalent in many societies, and studies have shown that pain could be preventable or managed more effectively at the population level. However, few studies have investigated who is at higher risk of pain in the general population, which is important for development of effective interventions. The purpose of this study was to investigate, by using nationally representative samples in Sweden, whether neighbourhood socioeconomic status (SES) is associated with pain among older adults after considering other important risk factors.MethodsThe study used the Statistics on Income and Living Conditions (EU‐SILC), which is a nationwide annual survey of the living conditions of residents in Sweden. We used the data of individuals who were over 65 years of age between 2008 and 2013. Multivariable logistic regression was conducted to investigate the association between neighbourhood SES and severe pain.ResultsThose who resided in low SES neighbourhoods had a 30% higher odds of having severe pain than those who resided in high SES neighbourhoods after controlling for individual risk factors, such as the sex, age, individual SES, smoking, exercise habits and body mass index. Exercise was protective against severe pain.ConclusionGiven the high prevalence of pain across populations, interventions targeting geographic areas (such as those in the current study) in combination with individual risk factors could be effective to reduce the burden of pain at the population level.SignificanceThose who reside in neighbourhoods with low SES may have higher risks of pain due to a lack of health‐promoting resources as well as psychological stress. Further studies identifying the specific mechanisms behind the association between neighbourhood SES and pain would be useful in order to develop effective interventions.
Converting the energy of sea waves into electrical energy
Authors: Kassayeva Assylkanym , Balekova Aknur , Yerzhanov Kalyy 
Published: January 2024

AbstractThe study is highly relevant as ocean waves hold significant potential for producing electricity. Improvements in production, usage and rectification of research errors are crucial for meeting the energy demands of diverse consumers. The aim of this work is to put forward recommendations for eliminating design and implementation errors in wave energy conversion systems, specifically for offshore power plants, and to analyze their performance. Various methods were employed, including the analytical method, classification method, functional method, statistical method, synthesis method, and others. During the study, the characteristics and differences of ocean waves were observed, along with an analysis of the errors that can occur during the operation of offshore power plants designed for wave energy production and their associated causes. Uncertainties affecting the development of these power stations were identified, and the potential of sea waves as an energy resource was examined. Recommendations for enhanced regulation were put forward. The practicality lies in applying the identified findings to rectify errors in offshore power stations that use sea waves. This guarantees reliable operation by considering various factors and assists in recommending the optimal use of energy resources.
Enhancing the Metalating Power of ZnEt2 via Formation of an Alkyl/Alkoxide Potassium Zincate
Authors: Kocher Jasmin , Judge Neil R. , Hevia Eva 
Published: January 2024

AbstractAdvancing the use of alkali‐metal alkoxides as additives to activate organometallic reagents, here we report the synthesis and characterization of a novel potassium zincate [{(PMDETA)KZn(OtBu)Et2}2] obtained by co‐complexation of equimolar amounts of potassium tert‐butoxide, diethyl zinc and the tridentate donor PMDETA (N,N,N’,N’’,N’’‐pentamethyldiethylenetriamine). Demonstrating its ability to activate both of the Et groups towards alkyne C−H metalation, this zincate reacts at room temperature with 2 equivalents of phenylacetylene to furnish [(THF)2KZn(CCPh)2(OtBu)}2], whereas, for the homometallic [ZnEt2(TMEDA)] (TMEDA=N,N,N’,N’‐tetramethylethylendiamine) only one Et group is reactive towards the same substrate under the same conditions. Investigations on the reactivity of these complexes to undergo N−H amine metalation using 2, 6‐diisopropylphenylamine (NH2Dipp) and 1,2,3,4‐tetrahydroquinoline (THQ(H)) as model substrates revealed that while homometallic [ZnEt2(TMEDA)] is completely inert towards these amines, heterobimetallic [{(PMDETA)KZn(OtBu)Et2}2] reacts through one of its Et groups to form [(THF)2KZn(OtBu)(Et)(NHDipp)] as well as [(THF)4K2Zn(THQ)4]. The latter is obtained as a side product of ligand redistribution of a putative [(THF)nKZn(OtBu)(Et)(THQ)] intermediate. An alternative method to access mixed amide/alkoxide potassium zincates is also described by assessing the co‐complexation of KOtBu with Zn(HMDS)2 in the presence of PMDETA which gave [(PMDETA)KZn(HMDS)2(OtBu)].
Novel chimeric antigen receptor‐expressing T cells targeting the malignant mesothelioma‐specific antigen sialylated HEG1
Authors: Kouro Taku , Higashijima Naoko , Horaguchi Shun , Mano Yasunobu , Kasajima Rika , Xiang Huihui , Fujimoto Yuki , Kishi Hiroyuki , Hamana Hiroshi , Hoshino Daisuke , Himuro Hidetomo , Matsuura Rieko , Tsuji Shoutaro , Imai Kohzoh , Sasada Tetsuro 
Published: January 2024

AbstractThe selection of highly specific target antigens is critical for the development of clinically efficient and safe chimeric antigen receptors (CARs). In search of diagnostic marker for malignant mesothelioma (MM), we have established SKM9‐2 monoclonal antibody (mAb) which recognizes a MM‐specific molecule, sialylated Protein HEG homolog 1 (HEG1), with high specificity and sensitivity. In this study, to develop a novel therapeutic approach against MM, we generated SKM9‐2 mAb‐derived CARs that included the CD28 (SKM‐28z) or 4‐1BB (SKM‐BBz) costimulatory domain. SKM‐28z CAR‐T cells showed continuous growth and enhanced Tim‐3, LAG‐3, and PD‐1 expression in vitro, which might be induced by tonic signaling caused by self‐activation; however, these phenotypes were not observed in SKM‐BBz CAR‐T cells. In addition, SKM‐BBz CAR‐T cells exhibited slightly stronger in vitro killing activity against MM cell lines than SKM‐28z CAR‐T cells. More importantly, only SKM‐BBz CAR‐T cells, but not SKM‐28z CAR‐T cells, significantly inhibited tumor growth in vivo in a MM cell line xenograft mouse model. Gene expression profiling and reporter assays revealed differential signaling pathway activation; in particular, SKM‐BBz CAR‐T cells exhibited enhanced NF‐kB signaling and reduced NFAT activation. In addition, SKM‐BBz CAR‐T cells showed upregulation of early memory markers, such as TCF7 and CCR7, as well as downregulation of pro‐apoptotic proteins, such as BAK1 and BID, which may be associated with phenotypical and functional differences between SKM‐BBz and SKM‐28z CAR‐T cells. In conclusion, we developed novel SKM9‐2‐derived CAR‐T cells with the 4‐1BB costimulatory domain, which could provide a promising therapeutic approach against refractory MM.
Trps1 predicts poor prognosis in advanced high grade serous ovarian carcinoma
Authors: Wang Xiaojiang , Sun Jiandong , Liu Yue , Lin Zihang , Jiang Xia , Ye Yuhong , Lv Chengyu , Lian Xiuli , Xu Weiwei , Luo Shanshan , Liao Shumin , Chen Zhangting , Wang Shie 
Published: January 2024

AbstractTRPS1 is aberrantly expressed in a variety of tumors, including breast, prostate, and gastric cancers, and is strongly associated with tumorigenesis or prognosis. However, the role of TRPS1 in high grade serous ovarian carcinoma (HGSC) is unknown. We investigated the relationship between TRPS1 expression and clinicopathology in HGSC patients. The tumor‐related regulatory mechanisms of TRPS1 was explored through in vivo and vitro experiments. The results showed that TRPS1 was highly expressed in HGSC compared to normal tissues. It was also linked to the cell proliferation index Ki67 and poor prognosis. In vivo experiments showed that knockdown of TRPS1 could inhibit tumor growth. In vitro experiments, knockdown of TRPS1 inhibited the proliferation of ovarian cancer cells. TRPS1 exerted its regulatory role as a transcription factor, binding to the PSAT1 promoter and promoting the expression of PSAT1 gene. Meanwhile, PSAT1 was positively correlated with CCND1 expression. These results suggest that TRPS1 affects HGSC proliferation and cell cycle by regulating PSAT1 and thus CCND1 expression.