bluuebunny/crossref_metadata_2025_split huggingface dataset:
Comparative Benefit of Evening Primrose Oil and Soybean Oil on Treatment Satisfaction and Quality of Life among Postmenopausal Women
Authors: Mohammed Raghad , Manal Khalid Abdulridha  , Bushrah Abd Al-Jbori  
Published: February 2024

Background: Medicinal herbs as alternative therapies, commonly used to treat menopausal symptoms, and some studies have shown that they can be useful in treating menopausal syndrome, which have been linked to worse self-rated health, and decreased work productivity.
Aim of the study: This study compared the effectiveness of EPO and Soybean Oil herbal supplement in a sample of Iraqi postmenopausal women on treatment satisfaction and their quality of life.
Patients and methods: This prospective study conducted on 20 post-menopausal women who received 500 mg EPO compared to other 20 received 233 mg soybean oil extract, as a capsule twice a day for 8 weeks. The subjective and clinical assessments of Menopause Symptom Treatment Satisfaction, and Menopause-Specific Quality of Life. Data was collected by the researcher via face-to-face interviews with women at baseline and after 2 months of treatment.
Results: In this study, Menopause Symptoms Treatment Satisfaction score was not significant within each group post treatment (P>0.05). While after 2 months of treatment, EPO significantly improved the quality of life by decreasing all MEN-QoL domains more than soybean oil, except for the sexual domain (P<0.01).
Conclusions: This study revealed that both EPO and soya bean oil supplements had the beneficial effect in improving the postmenopausal quality of life with less treatment satisfaction.
Rancang Bangun Aplikasi Badan Eksekutif Mahasiswa STMIK Palangkaraya Berbasis Framework Codeigniter
Authors: Setiawan Adi Firman , Sam'ani Sam'ani , Suratno Suratno , Maryamah Siti 
Published: February 2024

STMIK Palangkaraya adalah salah satu perguruan tinggi komputer yang berada di kota Palangkaraya, yang memiliki suatu organisasi mahasiswa yang dinamakan dengan Badan Eksekutif Mahasiswa atau biasa disingkat dengan istilah BEM yang berfungsi sebagai induk dari semua organisasi mahasiswa untuk menampung dan meneruskan aspirasi dari mahasiswa. Saat ini untuk cara penyampaian sebuah informasi tentang kegiatan yang diadakan oleh BEM STMIK Palangkaraya adalah menggunakan media sosial dan mading kampus. Permasalahan dalam penelitian ini adalah yang bagaimana merancang dan membuat Aplikasi Web Badan Eksekutif Mahasiswa dengan fitur Polling pemilihan Presiden dan Wakil Presiden STMIK Palangka Raya Berbasis Framework CodeIgniter. Teknologi yang digunakan berbasis web dengan menggunakan bahasa pemrograman php, database . Website ini dibuat menggunakan Framework CodeIgniter (CI). Hasil penelitian ini adalah telah berhasil diimplementasikan sebuah aplikasi web badan eksekutif mahasiswa pada STMIK Palangka Raya menggunakan Framework CodeIgniter.
Identification Of Nutritional Adequacy Of Pregnant Women With The Figo Nutrition Checklist
Authors: Hanifah Dewi 
Published: February 2024

Latar Belakang: Gizi dalam kehamilan mempunyai implikasi penting terhadap kesehatan ibu dan anak. Gizi selama kehamilan yang optimal, akan mendorong pertumbuhan dan perkembangan janin yang optimal.Tujuan: Mengidentifikasi kecukupan zat gizi pada ibu hamil di Puskemas Kota Sukabumi dan mengidentifikasi kelompok ibu hamil yang beresiko mengalami masalah giziMetode : Desain penelitian analitik observasional dengan pendekatan cross sectional menggunakan data primer dengan mengukur kecukupan gizi ibu hamil dengan instrumen FIGO Nutrition Checklist. Sampel dalam penelitian ini sebanyak 65 orang dengan teknik pengambilan sampel menggunakan consecutive sampling. Penelitian dilaksanakan di Puskesmas PONED Sukabumi pada bulan Juli – September 2022. Analisis data menggunakan Chi Square.Hasil: Masih terdapat ibu hamil dengan status gizi kurang (7,7%) dan status gizi lebih (30,8%). Hanya 20% ibu hamil dengan kualitas diet memenuhi indikator instrumen FIGO Nutrition Checklist. Variasi jenis makanan yang dikonsumsi ibu hamil belum memenuhi kebutuhan diet yang disarankan. Faktor demografi yang berhubungan dengan kualitas diet adalah pendidikan ibu (p<0,05). Kesimpulan: Kebutuhan gizi selama kehamilan belum memenuhi indikator FIGO Nutrition Checklist, terdapat ibu hamil dengan gangguan nutrisi.Saran: Perlu dilakukan edukasi gizi terhadap ibu hamil melalui pelayanan antenatal. Kata Kunci: FIGO,Nutrition, Checklist ABSTRACT Background: A balanced diet during pregnancy is crucial for optimal fetal growth and development.Objective: This study aims to assess the nutritional adequacy of pregnant women attending the Sukabumi Public Health Center and identify groups of pregnant women at risk of nutritional problems.Methods: This observational study used the FIGO Nutrition Checklist to measure the nutritional adequacy of 65 pregnant women at the Sukabumi Public Health Center from July to September 2022, using chi-square for data analysis.Results: The study found that some pregnant women suffered from undernutrition (7.7%) and overnutrition (30.8%). Only 20% of pregnant women met the indicators of the FIGO Nutrition Checklist instrument, indicating that their diet quality was appropriate. The study also revealed that the variety of foods consumed by pregnant women did not meet the recommended dietary needs. Maternal education was found to be associated with diet quality (p<0.05).Conclusion: The results suggest that pregnant women's nutritional needs are not being met according to the FIGO Nutrition Checklist indicators, and some women are experiencing nutritional disorders.Suggestion: It is recommended that antenatal care should include nutrition education for pregnant women to ensure that they receive adequate nutrition during pregnancy. Keywords: FIGO, Nutrition,Checklist
Regulation Learning Qur’an: Upaya Membangun Kemandirian Belajar Abad 21
Authors: Lutfi Saiful , Surawan Surawan , Zanuba Adisty Arselia 
Published: February 2024

Penelitian ini dilatar belakangi oleh fenomena yang terjadi dilapangan, peneliti melihat sebagian remaja di Desa Ruwuk Ranggan kurang memperhatikan tanggung jawab intelektualnya, khususnya dalam pembelajaran Al-Qur’an. Penelitian ini bertujuan untuk mendeskripsikan tentang self-regulated learning pada remaja di Desa Ruwuk Ranggan Kecamatan Cempaga Kabupaten Kotawaringin Timur. Penelitian ini menggunakan pendekatan kualitatif deskriptif dengan teknik pengumpulan data menggunakan observasi, wawancara, dan dokumentasi. Hasil penelitian ini didapatkan bahwa mayoritas remaja di Desa Ruwuk Ranggan memiliki self-regulated learning yang rendah, terkhusus dalam belajar Al-Qur’an secara mandiri, namun ada juga sebagian remaja yang memiliki self-regulated learning yang tinggi. self-regulated learning pada remaja dalam belajar Al-Qur’an dipengaruhi oleh beberapa faktor pendukung yaitu; 1) keyakinan diri (Self efficacy), 2) motivasi diri (Self-motivation), 3) dukungan sosial.
Cardiac autonomic regulation in response to functional power threshold testing in elite cyclists.
Authors: Castillo-Aguilar Matías , Mabe-Castro Diego , Mabe-Castro Matías , Oyarzo Valeska , Harris King Katherine , Valdés-Badilla Pablo , Delgado-Floody Pedro , González-Puelma Jorge , Núñez Espinosa Cristian Andrés 
Published: February 2024

Objective: To evaluate the impact of a functional power threshold test (FTP) on cardiac autonomic regulation indicators in high performance cyclists.
Methods: A total of 12 male elite cyclists (mean age 36.1 ± 11.2 years) were recruited. Body composition parameters were measured using bioimpedancemetry and heart rate variability (HRV) before and after the application of the FTP assessment.
Results: We observed that a greater sympathetic nervous system (SNS) index and Stress index on baseline were correlated with a smaller decrease in the parasympathetic nervous system (PNS) activity in response to the FTP test (rho = 0.69, p = 0.013). Concerning morphological parameters, the skeletal muscle index (SMI) was the only one that was inversely correlated with ∆PNS (rho = -0.69, p = 0.02) whereas the muscle-bone index (MBI) displayed a positive correlation with ∆SNS (rho = 0.82, p = 0.001). In fully adjusted models we found that waist-to-hip ratio (beta = 7.90, CI95%[4.16, 11.63], t(8) = 4.88, p = 0.001) and SMI significantly influenced ∆PNS (beta = -1.38, CI95%[-1.84, -0.92], t(8) = -6.94, p < 0.001), whereas MBI (beta = 10.26, CI95%[8.10, 12.42], t(8) = 10.96, p < 0.001) and the interaction between the latter and Power achieved during FTP influenced ∆SNS (beta = -0.05, CI95%[-0.09, -4.99e-03], t(8) = -2.56, p = 0.033).
Conclusion: Our findings indicate that the SMI had a negative effect on the ∆PNS, while the MBI was positively correlated with the ∆SNS in cyclists. These findings suggest that a higher SMI and MBI could have a detrimental impact on the cardiac autonomic response to maximal aerobic exercise in high-performance cyclists, such as FTP.
The Influence of Dhikr on Anxiety in Acute Coronary Syndrome (ACS) Patients at Dr. Chasbullah Abdulmadjid Hospital, Bekasi City
Authors: Sulistiyowati Heppy , Jumaiyah Wati , Purnamawati Dewi , Sofiani Yani , Susanto Budi , Prima Ashar , Hamdah Hamdah 
Published: February 2024

Aims: This study was to determine the effect of dhikr on anxiety in ACS patients at Dr. Chasbullah Abdulmadjid General Hospital, Bekasi City.
Methods: The research method used pre- and post-quasy experiments in the control group and the intervention group. This study used the HARS questionnaire and family support for 76 respondents.
Result: Data analysis using multiple logistic regression tests The results showed that the proportion in the control group with mild-moderate anxiety was 31.6% and severe anxiety was 18.4%; the proportion in the intervention group with mild-moderate anxiety was 46.1% and severe anxiety was 3.9%. Dhikr (p = 0.006) and history of heart disease (p = 0.023) significantly influence anxiety after being controlled by age (p = 0.244) (p = 0.001 omnimbus). The dominant factor that influences anxiety is dhikr (OR 10.674).
Conclusions : Dhikr is an act of remembering Allah that can be used to reduce anxiety in SKA patients. This can be done independently by reading istigfar, tasbih, hauqalah, and takbir for 15 minutes in the morning and evening. Therefore, nursing services using dhikr as an effort to reduce anxiety in ACS patients.
Effect of Isometric Handgrip Exercise on Sleep Quality of Hypertension Patients in the Elderly
Authors: Lucya Vita , Pratiwi Gilang Dwi , Anggie Novita 
Published: February 2024

Aims: The study aimed to knowing the effect of isometric handgrip exercise on the quality of sleep of hypertension patients in the elderly.
Methods: The study was Quasi Experiment research with one group pretest-posttest design. The study population was purposive sampling and obtained a total of 30 respondents. This research was conducted at the Sukawarna Health Center Work Area, Bandung City. The instrument used was PSQI (Pittsburgh Sleep Quality Index).
Results: There was an effect ofisometric handgrip exercise on the quality of sleep of hypertension patients in the elderly (p-value = 0,000).
Conclusion: Isometric handgrip exercise is a non-pharmacological therapy that can be used to improve quality of sleep of hypertension patients in the elderly.
A nomogram for predicting left atrial thrombus or spontaneous echo contrast in non-valvular atrial fibrillation patients using hemodynamic parameters from transthoracic echocardiography
Authors: Zeng Decai , Zhang Xiaofeng , Chang Shuai , Zhong Yanfen , Cai Yongzhi , Huang Tongtong , Wu Ji 
Published: February 2024

BackgroundAtrial fibrillation (AF) is the most common cardiac arrhythmia and is associated with a high risk of stroke. This study was designed to investigate the relationship between hemodynamic parameters and left atrial thrombus/spontaneous echo contrast (LAT/SEC) in non-valvular atrial fibrillation (NVAF) patients and establish a predictive nomogram that integrates hemodynamic parameters with clinical predictors to predict the risk of LAT/SEC.MethodsFrom January 2019 to September 2022, a total of 354 consecutive patients with NVAF were enrolled in this cross-sectional study at the First Affiliated Hospital of Guangxi Medical University. To identify the optimal predictive features, we employed least absolute shrinkage and selection operator (LASSO) regression. A multivariate logistic regression model was subsequently constructed, and the results were visualized with a nomogram. We evaluated the model's performance using discrimination, calibration, and the concordance index (C-index).ResultsWe observed a 38.7% incidence of SEC/TH in NVAF patients. Independent influencing factors of LAT/SEC were identified through LASSO and multivariate logistic regression. Finally, four indicators were included, namely, previous stroke/transient ischaemic attack (OR = 4.25, 95% CI = 1.57–12.23, P = 0.006), left atrial volume index (LAVI) (OR = 1.04, 95% CI = 1.01–1.06, P = 0.001), S/D ratio (OR = 0.27, 95% CI = 0.11–0.59, P = 0.002), and left atrial acceleration factor (OR = 4.95, 95% CI = 2.05–12.79, P = 0.001). The nomogram, which incorporated these four influencing factors, demonstrated excellent predictive ability. The training set had a C-index of 0.878, while the validation set had a C-index of 0.872. Additionally, the calibration curve demonstrated great consistency between the predicted probabilities and the observed outcomes, and the decision curve analysis confirmed the important clinical advantage of the model for patients with NVAF.ConclusionOur findings indicate that an enlarged left atrium and abnormal hemodynamic parameters in the left atrial and pulmonary veins are linked to a greater risk of LAT/SEC. Previous stroke/transient ischaemic attack, LAVI, the S/D ratio, and left atrial acceleration factor were independently associated with LAT/SEC in NVAF patients. With the incorporation of these four variables, the developed nomogram effectively predicts the risk of LAT/SEC and outperforms the CHA2DS2-VASc score.
Comparative prognosis and risk assessment in gallbladder neuroendocrine neoplasms versus adenocarcinomas
Authors: Zhao Zhi-Hao , Huang Yu , Jiang Chao , Lv Guo-Yue , Wang Meng 
Published: February 2024

BackgroundGallbladder neuroendocrine neoplasms (GB-NENs) are a rare malignant disease, with most cases diagnosed at advanced stages, often resulting in poor prognosis. However, studies regarding the prognosis of this condition and its comparison with gallbladder adenocarcinomas (GB-ADCs) have yet to yield convincing conclusions.MethodsWe extracted cases of GB-NENs and GB-ADCs from the Surveillance, Epidemiology, and End Results (SEER) database in the United States. Firstly, we corrected differences in clinical characteristics between the two groups using propensity score matching (PSM). Subsequently, we visualized and compared the survival outcomes of the two groups using the Kaplan-Meier method. Next, we employed the least absolute shrinkage and selection operator (LASSO) regression and Cox regression to identify prognostic factors for GB-NENs and constructed two nomograms for predicting prognosis. These nomograms were validated with an internal validation dataset from the SEER database and an external validation dataset from a hospital. Finally, we categorized patients into high-risk and low-risk groups based on their overall survival (OS) scores.ResultsA total of 7,105 patients were enrolled in the study, comprising 287 GB-NENs patients and, 6,818 GB-ADCs patients. There were substantial differences in clinical characteristics between patients, and GB-NENs exhibited a significantly better prognosis. Even after balancing these differences using PSM, the superior prognosis of GB-NENs remained evident. Independent prognostic factors selected through LASSO and Cox regression were age, histology type, first primary malignancy, tumor size, and surgery. Two nomograms for prognosis were developed based on these factors, and their performance was verified from three perspectives: discrimination, calibration, and clinical applicability using training, internal validation, and external validation datasets, all of which exhibited excellent validation results. Using a cutoff value of 166.5 for the OS nomogram score, patient mortality risk can be identified effectively.ConclusionPatients with GB-NENs have a better overall prognosis compared to those with GB-ADCs. Nomograms for GB-NENs prognosis have been effectively established and validated, making them a valuable tool for assessing the risk of mortality in clinical practice.
Improving lithium battery cooling: analyzing the impact of air flow, nanofluid flow, and phase change materials
Authors: Mustafa Jawed , Alqaed Saeed , Sajadi S. Mohammad , Aybar Hikmet Ş. 
Published: February 2024

In this study, a finite element analysis is employed to numerically investigate the thermal behavior of a battery pack comprising cylindrical lithium-ion cells. The system incorporates air cooling with phase change material (PCM) surrounding the batteries and nanofluid (NFD) circulating within the PCM through tubes of varying diameters (ranging from 2 mm to 6 mm) at flow rates (FRT) spanning 5 mL/min to 20 mL/min. A two-phase mixture model is applied to analyze the behavior of the NFD as it changes phase. The transient simulation covers a 1-h period to assess temperature variations of the NFD, batteries, surrounding air, PCM, and the phase change process within the PCM. Our results indicate that variations in NFD flow rate (NFFR) do not significantly affect the PCM’s molten fraction during PCM melting, coinciding with an increase in battery temperature (TBT). However, during the PCM refreezing phase, a FRT of 15 mL/min results in the highest quantity of solid PCM. The outlet temperature (TOT) of the NFD demonstrates a cyclical pattern of increase and decrease over time. We observe that when the NFD temperature is elevated, the lowest TOT of the NFD is associated with a FRT of 5 mL/min. Conversely, when the NFD temperature is lowered, this FRT leads to the highest TOT of the NFD. The TBT exhibits some sensitivity to changes in FRT within the initial half-hour, with a subsequent decline, particularly with a FRT of 15 mL/min.
Mitochondrial-related hub genes in dermatomyositis: muscle and skin datasets-based identification and in vivo validation
Authors: Wang Shuo , Tang Yiping , Chen Xixi , Song Siyuan , Chen Xi , Zhou Qiao , Zeng Li 
Published: February 2024

Background: Mitochondrial dysfunction has been implicated in the pathogenesis of dermatomyositis (DM), a rare autoimmune disease affecting the skin and muscles. However, the genetic basis underlying dysfunctional mitochondria and the development of DM remains incomplete.Methods: The datasets of DM muscle and skin tissues were retrieved from the Gene Expression Omnibus database. The mitochondrial related genes (MRGs) were retrieved from MitoCarta. DM-related modules in muscle and skin tissues were identified with the analysis of weighted gene co-expression network (WGCNA), and then compared with the MRGs to obtain the overlapping mitochondrial related module genes (mito-MGs). Subsequently, differential expression genes (DEGs) obtained from muscle and skin datasets were overlapped with MRGs to identify mitochondrial related DEGs (mito-DEGs). Next, functional enrichment analysis was applied to analyze possible relevant biological pathways. We used the Jvenn online tool to intersect mito-MGs with mito-DEGs to identify hub genes and validate them using reverse transcription quantitative polymerase chain reaction (RT-qPCR) and immunohistochemistry staining. In addition, we evaluated immune infiltration in muscle and skin tissues of DM patients using the one-sample gene set enrichment analysis (ssGSEA) algorithm and predicted potential transcription factor (TF) -gene network by NetworkAnalyst.Results: The WGCNA analysis revealed 105 mito-MGs, while the DEG analysis identified 3 mito-DEGs. These genes showed functional enrichment for amino acid metabolism, energy metabolism and oxidative phosphorylation. Through the intersection analysis of the mito-MGs from the WGCNA analysis and the mito-DEGs from the DEG set, three DM mito-hub genes (IFI27, CMPK2, and LAP3) were identified and validated by RT-qPCR and immunohistochemistry analysis. Additionally, positive correlations were observed between hub genes and immune cell abundance. The TF-hub gene regulatory network revealed significant interactions involving ERG, VDR, and ZFX with CMPK2 and LAP3, as well as SOX2 with LAP3 and IFI27, and AR with IFI27 and CMPK2.Conclusion: The mito-hub genes (IFI27, CMPK2, and LAP3) are identified in both muscles and skin tissues from DM patients. These genes may be associated with immune infiltration in DM, providing a new entry point for the pathogenesis of DM.
Predicting the submission frequency of periodic safety update reports: development and application of the EURD tool
Authors: Gordillo-Marañón María , Candore Gianmario , López-Fauqued Marta , Deli Katerina-Christina , Piccolo Loris , Alcini Paolo , Paternoster-Howe Tom , Rager Irene , Ruepp Robin , van der Elst Menno 
Published: February 2024

IntroductionPeriodic Safety Update Reports (PSURs) are a key pharmacovigilance tool for the continuous evaluation of the benefit–risk balance of a medicinal product in the post-authorisation phase. The PSUR submission frequency for authorised active substances and combinations of active substances across the EU is individually determined. The objective of this research was the development and application of the EURD tool, a statistical method based on readily available safety data to predict PSUR frequencies and to ensure a consistent risk-based approach.MethodsFirst, variables considered relevant in determining the PSUR frequency were identified from data sources available at the European Medicines Agency. A subsequent first survey with National Competent Authorities in Europe lead to a prioritisation of identified variables, while a second survey was carried out to propose the PSUR frequencies for a set of substances. Finally, a regression model was built on the information collected, applied to a larger list of substances and its results tested via a third survey with the same experts.ResultsThe developed EURD tool was applied to the 1,032 EURD list entries with a PSUR assessment deferred to 2025 at the time of the creation of the list in 2012. As the number of procedures would have had a significant impact on the workload for the European Medicines Regulatory Network (EMRN), in a second step the workload impact was estimated after allocating the entries according to their proposed frequency. The analysis suggests that all entries could be reviewed by 2038 by increasing the median workload by 15% (from 868 to 1,000 substances/year).ConclusionThe EURD tool is the first data-driven application for supporting decision making of PSUR frequencies based on relevant active substance safety data. While we illustrated its potential for improving the assignment of PSUR submission frequencies for active substances authorised in the EU, other institutions requiring periodic assessment of safety data and balancing of the resulting workload could benefit from it.