bluuebunny/crossref_metadata_2025_split huggingface dataset:
Protective effects of macrophage-specific integrin α5 in myocardial infarction are associated with accentuated angiogenesis
Authors: Li Ruoshui , Chen Bijun , Kubota Akihiko , Hanna Anis , Humeres Claudio , Hernandez Silvia C. , Liu Yang , Ma Richard , Tuleta Izabela , Huang Shuaibo , Venugopal Harikrishnan , Zhu Fenglan , Su Kai , Li Jun , Zhang Jinghang , Zheng Deyou , Frangogiannis Nikolaos G. 
Published: November 2023

AbstractMacrophages sense changes in the extracellular matrix environment through the integrins and play a central role in regulation of the reparative response after myocardial infarction. Here we show that macrophage integrin α5 protects the infarcted heart from adverse remodeling and that the protective actions are associated with acquisition of an angiogenic macrophage phenotype. We demonstrate that myeloid cell- and macrophage-specific integrin α5 knockout mice have accentuated adverse post-infarction remodeling, accompanied by reduced angiogenesis in the infarct and border zone. Single cell RNA-sequencing identifies an angiogenic infarct macrophage population with high Itga5 expression. The angiogenic effects of integrin α5 in macrophages involve upregulation of Vascular Endothelial Growth Factor A. RNA-sequencing of the macrophage transcriptome in vivo and in vitro followed by bioinformatic analysis identifies several intracellular kinases as potential downstream targets of integrin α5. Neutralization assays demonstrate that the angiogenic actions of integrin α5-stimulated macrophages involve activation of Focal Adhesion Kinase and Phosphoinositide 3 Kinase cascades.
Wind-driven device for cooling permafrost
Authors: Qin Yinghong , Wang Tianyu , Yuan Weixin 
Published: November 2023

AbstractPreserving permafrost subgrade is a challenge due to global warming, but passive cooling techniques have limited success. Here, we present a novel wind-driven device that can cool permafrost subgrade by circulating coolant between the ambient air and the subgrade. It consists of a wind mill, a mechanical clutch with phase change material, and a fluid-circulation heat exchanger. The clutch engages and disengages through freezing and melting phase change material, while the device turns off when the outside air temperature exceeds a certain threshold, preventing heat from penetrating the subgrade. Two-year observations demonstrate that the device effectively cooled permafrost measuring 8.0 m in height and 1.5 m in radius by 0.6–1.0 °C, with an average power of 68.03 W. The device can be adapted for cooling embankments, airstrip bases, pipe foundations, and other structures. Further experimentation is required to evaluate its cooling capacity and long-term durability under various conditions.
Breaking the photoswitch speed limit
Authors: Thaggard Grace C. , Park Kyoung Chul , Lim Jaewoong , Maldeni Kankanamalage Buddhima K. P. , Haimerl Johanna , Wilson Gina R. , McBride Margaret K. , Forrester Kelly L. , Adelson Esther R. , Arnold Virginia S. , Wetthasinghe Shehani T. , Rassolov Vitaly A. , Smith Mark D. , Sosnin Daniil , Aprahamian Ivan , Karmakar Manisha , Bag Sayan Kumar , Thakur Arunabha , Zhang Minjie , Tang Ben Zhong , Castaño Jorge A. , Chaur Manuel N. , Lerch Michael M. , Fischer Roland A. , Aizenberg Joanna , Herges Rainer , Lehn Jean-Marie , Shustova Natalia B. 
Published: November 2023

AbstractThe forthcoming generation of materials, including artificial muscles, recyclable and healable systems, photochromic heterogeneous catalysts, or tailorable supercapacitors, relies on the fundamental concept of rapid switching between two or more discrete forms in the solid state. Herein, we report a breakthrough in the “speed limit” of photochromic molecules on the example of sterically-demanding spiropyran derivatives through their integration within solvent-free confined space, allowing for engineering of the photoresponsive moiety environment and tailoring their photoisomerization rates. The presented conceptual approach realized through construction of the spiropyran environment results in ~1000 times switching enhancement even in the solid state compared to its behavior in solution, setting a record in the field of photochromic compounds. Moreover, integration of two distinct photochromic moieties in the same framework provided access to a dynamic range of rates as well as complementary switching in the material’s optical profile, uncovering a previously inaccessible pathway for interstate rapid photoisomerization.
Ultrafast vibrational control of organohalide perovskite optoelectronic devices using vibrationally promoted electronic resonance
Authors: Gallop Nathaniel. P. , Maslennikov Dmitry R. , Mondal Navendu , Goetz Katelyn P. , Dai Zhenbang , Schankler Aaron M. , Sung Woongmo , Nihonyanagi Satoshi , Tahara Tahei , Bodnarchuk Maryna I. , Kovalenko Maksym V. , Vaynzof Yana , Rappe Andrew M. , Bakulin Artem A. 
Published: November 2023

AbstractVibrational control (VC) of photochemistry through the optical stimulation of structural dynamics is a nascent concept only recently demonstrated for model molecules in solution. Extending VC to state-of-the-art materials may lead to new applications and improved performance for optoelectronic devices. Metal halide perovskites are promising targets for VC due to their mechanical softness and the rich array of vibrational motions of both their inorganic and organic sublattices. Here, we demonstrate the ultrafast VC of FAPbBr3 perovskite solar cells via intramolecular vibrations of the formamidinium cation using spectroscopic techniques based on vibrationally promoted electronic resonance. The observed short (~300 fs) time window of VC highlights the fast dynamics of coupling between the cation and inorganic sublattice. First-principles modelling reveals that this coupling is mediated by hydrogen bonds that modulate both lead halide lattice and electronic states. Cation dynamics modulating this coupling may suppress non-radiative recombination in perovskites, leading to photovoltaics with reduced voltage losses.
Spatial variation and factors associated of solid fuel use in Ethiopia a multilevel and spatial analysis based on EDHS 2016
Authors: Azanaw Jember , Melaku Mequannent Sharew 
Published: November 2023

AbstractCooking and heating using solid fuels, such as dung, wood, agricultural residues, grass, straw, charcoal, and coal, is a main source of household air pollution. This indoor combustion encompasses a diversity of health detrimental pollutants, especially for people from low-income countries like Ethiopia since solid fuels are accessible easily at a lesser cost. Limited studies done showing factors affecting in choosing fuel type and no study, which revealed spatial heterogeneity of solid fuel used based on such nationally representative data. Therefore, this study, aimed at investigating spatial variation and determinants of solid fuel use in Ethiopia. This study was done using the data from the Ethiopian Demographic and Health Survey 2016, a national representative sample (16,650) households were included. Spatial and Multi-level logistic regression analysis was done by considering the DHS data hierarchal nature. Variables in the final model with a p-value < 0.05 were reported as significant predictors of using solid fuel. All analyses were done using ArcGIS V.10.7.1 and STATA V.14 software. The finding of this study revealed that 90.8% (95% CI (87.9%, 91.2%)) of households depend on solid fuel for cooking. Based on the final model ;Male household head (AOR 1.38, 95% CI (1.12–1.71)), age of household head (AOR 1.61, 95% CI (1.20, 2.17)), and 1.49 (OR 1.49, 95% CI (1.12, 1.99)) respectively for the age classes of < 30, and 30–40, education attainment no education (OR 3.14, 95% CI (1.13, 8.71)) and primary education (AOR 2.16, 95% CI (2.78, 5.96), wealth index Poorest (AOR 11.05, 95% CI (5.68, 15.78)), Poorer (OR 5.19, 95% CI (5.43, 13.19)), Middle (OR 3.08, 95% CI (2.44, 8.73)), and Richer (OR 1.30, 95IC (1.07, 13.49)) compared to richest, and not accessibility of electricity (AOR 31.21, 95% CI (35.41, 42.67)), were individual-level factors significantly associated with using solid fuel. Community-level factors like households found at large city (AOR 2.80, 95CI (1.65, 4.77)), small city (AOR 2.58, 95% CI (1.55, 4.32)) town (AOR 4.02, 95% CI (2.46, 6.55)), and countryside (AOR 14.40, 95% CI (6.23, 21.15)) compared households found in capital city, community level media exposure (AOR 6.00, 95% CI (4.61, 7.82)) were statistically predictors in using solid fuel for cooking. This finding revealed that a large proportion of households in Ethiopia heavily depend on biomass, especially wood, for cooking. There was a greater disparity on solid fuel use for cooking in Ethiopia. Implementing major policy interventions should be introduced to reduce solid fuel use for cooking and inequalities in accessing clean fuel in Ethiopia.
Efficient spatial and channel net for lane marker detection based on self-attention and row anchor
Authors: Fan Shengli , Zhang Yuzhi , Lu Shengrong , Bi Xiaohui 
Published: November 2023

AbstractLane detection is an important component of advanced driving aided system (ADAS). It is a combined component of the planning and control algorithms. Therefore, it has high standards for the detection accuracy and speed. Recently several researchers have worked extensively on this topic. An increasing number of researchers have been interested in self-attention-based lane detection. In difficult situations such as shadows, bright lights, and nights extracting global information is effective. Regardless of channel or spatial attention, it cannot independently extract all global information until a complicated model is used. Furthermore, it affects the run-time. However trading in this contradiction is challenging. In this study, a new lane identification model that combines channel and spatial self-attention was developed. Conv1d and Conv2d were introduced to extract the global information. The model is lightweight and efficient avoiding difficult model calculations and massive matrices, In particular obstacles can be overcome under certain difficult conditions. We used the Tusimple and CULane datasets as verification standards. The accuracy of the Tusimple benchmark was the highest at 95.49%. In the CULane dataset, the proposed model achieved 75.32% in F1, which is the highest result, particularly in difficult scenarios. For the Tusimple and CULane datasets, the proposed model achieved the best performance in terms of accuracy and speed.
Statistical characteristics of comic panel viewing times
Authors: Ikuta Hikaru , Wöhler Leslie , Aizawa Kiyoharu 
Published: November 2023

AbstractComics are a bimodal form of art involving a mixture of text and images. Since comics require a combination of various cognitive processes to comprehend their contents, the analysis of human comic reading behavior sheds light on how humans process such bimodal forms of media. In this paper, we particularly focus on the viewing times of each comic panel as a quantitative measure of attention, and analyze the statistical characteristics of the distributions of comic panel viewing times. We create a user interface that presents comics in a panel-wise manner, and measure the viewing times of each panel through a user study experiment. We collected data from 18 participants reading 7 comic book volumes resulting in over 99,000 viewing time data points, which will be released publicly. The results show that the average viewing times are proportional to the text length contained in the panel’s speech bubbles, with a rate of proportion differing for each reader, despite the bimodal setting. Additionally, we find that the viewing time for all users follows a common heavy-tailed distribution.
Influence of phytocenosis on the medical potential of moss extracts: the Pleurozium schreberi (Willd. ex Brid.) Mitt. case
Authors: Wolski Grzegorz J. , Kobylińska Agnieszka , Sadowska Beata , Podsędek Anna , Kajszczak Dominika , Fol Marek 
Published: November 2023

AbstractThe question was asked “whether plant phytocenosis has an impact on the medical potential of the extracts from Pleurozium schreberi”. Moss samples were collected from four different phytocoenoses: mixed forest (oak-pine forest), a forest tract in pine forest, 5–15-year-old pine forest and 50-year-old pine forest. Chemical composition of the extracts, antioxidative capacity (FRAP and ABTS·+ assays), as well as biological activities including cytotoxicity for the mouse fibroblasts L929 line (MTT reduction assay), biostatic/biocidal effect against selected bacteria and fungi (broth microdilution method followed by culture on solid media), and regenerative properties on human fibroblasts HFF-1 line (scratch assay) were tested. The conducted research clearly proves that phytocenosis determines the quality of moss extracts. The analyses showed that in every examined aspect the IV-7 extract (obtained from a specimen collected in a Pinus sylvestris L. forest, monoculture up to 15 years old) exhibited the highest values and the strongest activity. Other extracts of the same species but growing in other phytocenoses—in a mixed forest (IV-5), a forest tract in a Pinus sylvestris monoculture forest (IV-6) and in a P. sylvestris forest of pine monoculture about 50 years old (IV-8) showed much weaker activity and lower values of the above-mentioned parameters. At the same time, none of the tested extracts exerted a pro-regenerative effect. The P. schreberi extracts were characterized by a varied total content of phenolic compounds in the range from 0.63 ± 0.02 to 14.01 ± 0.25 mg/g of plant material. UPLC/MS analysis showed a varied phenolic profile of the extracts, with caffeoylquinic acid and quercetin triglucoside predominating in all of them.
Causal association of calcific aortic valve stenosis and atrial fibrillation: a Mendelian randomization study
Authors: Chai Chen , Li Shoupeng , Chen Lin , Song Xiaobing 
Published: November 2023

AbstractCalcific aortic valve stenosis (CAVS) is associated with an increased risk of atrial fibrillation (AF) in observational studies, but whether these associations are causal has not been determined. This study aimed to explore the potential causal relationship between CAVS and AF via Mendelian randomization (MR). Genetic variants from the genome-wide association study (GWAS) summary data of the European population for CAVS were used to investigate the association with AF. The inverse variance weighted (IVW) approach was used to obtain the primary causal inference, and several sensitivity analysis approaches, such as the MR‒Egger and weighted median (WM), were performed to assess the robustness of the results. A total of nineteen valid and independent genetic SNPs associated with CAVS were obtained from the GWAS database. Genetically predicted CAVS (OR: 1.105; 95% CI: 1.072–1.139; p = 8.60E−11) was associated with an increased risk of AF. Similar results were discovered in the sensitivity analyses by using MR Egger and weighted median approaches. An MR design was used to reduce confounding variables and the potential for reverse causality bias. The results provide genetic evidence that CAVS considerably increased the risk of AF.
Verfahren der künstlichen Intelligenz – eine Perspektive für die kardiovaskuläre Telemedizin?
Authors: Römmelt Constantin , Hiddemann Meike , Köhler Kerstin , Köhler Friedrich 
Published: November 2023

ZusammenfassungGeschätzte 150000–200000 herzinsuffiziente Patient*innen in Deutschland haben seit 2022
durch einen Beschluss des Gemeinsamen Bundesausschusses (G-BA) Anspruch auf eine
telemedizinische Mitbetreuung. Aktuell sind KI-Anwendungen (KI: künstliche Intelligenz) in der
kardiovaskulären Telemedizin für die Regelversorgung nicht zulässig. Die Anwendung von KI
könnte jedoch helfen, die Vorhersagegenauigkeit der etablierten telemedizinischen Sensorik
durch Mustererkennung unter Einbeziehung multipler Datenquellen zu verbessern. Zudem befinden
sich neue KI-basierte Biomarker in der Entwicklung, um in der telemedizinischen Sensorik
eingesetzt zu werden. Vielversprechend erscheint dabei der Ansatz der Stimmanalyse zur
Erkennung einer pulmonalen Kongestion. KI-basierte Entscheidungsunterstützungssysteme könnten
zukünftig dabei helfen, den Befundungsprozess im Telemedizinzentrum zu optimieren.
Large-Language-Modelle bieten das Potenzial, zukünftig die Befunderstellung zu unterstützen.
Die Forschung zur digitalen Medizin bedarf klarer Rahmenbedingungen, um neue KI-basierter
Technologien im Gesundheitswesen in der Patientenanwendung prüfen zu können.
Auf der Suche nach der Evidenz: Eine systematische
Übersichtsarbeit zur Pathologie des Lipödems
Authors: Funke Sarah , Kuhlmann Constanze , Taha Sara , Fuchs Benedikt , Wiggenhauser Paul Severin , Giunta Riccardo E. 
Published: November 2023

Zusammenfassung
Hintergrund Das Lipödem bezeichnet eine symmetrisch lokalisierte,
schmerzhafte Vermehrung des subkutanen Fettgewebes an den Extremitäten
mit deutlicher Disproportion zum Stamm, von der fast ausschließliche
Frauen betroffen sind. Obwohl die Erstbeschreibung über 80 Jahre
zurückliegt, sind die Ätiologie und Pathogenese der Erkrankung
bislang weitestgehend ungeklärt und zurzeit Inhalt intensiver
Forschungsarbeit.
Methoden Zur Zusammenfassung der aktuellen evidenz-basierten Literatur zur
Pathologie, Pathohistologie und Pathogenese des Lipödems erfolgte eine
PRISMA-basierte systematische Literaturrecherche innerhalb der National Library
of Medicine und Cochrane-Datenbank.
Ergebnisse Insgesamt konnten 53 Studien identifiziert und in diese
Übersicht inkludiert werden. Die Ergebnisse wurden in Kategorien
klassifiziert und zusammengefasst.
Schlussfolgerung Trotz einer deutlichen Zunahme der
Forschungsaktivität und der Veröffentlichung umfangreicher
Studien mit histologischem und molekulargenetischem Schwerpunkt in den letzten
Jahren, bleibt die grundlegende Ätiologie und Pathologie der Erkrankung
Lipödem weitestgehend uneindeutig. Die aktuelle Datenlage weist
studienübergreifend Diskrepanzen auf, insbesondere die
„ödematöse“ Komponente des Lipödems ist
umstritten. Die häufig-vorliegenden Ko-Morbiditäten
„Lymphödem“ und „Übergewicht“,
vornehmlich in fortgeschrittenen Stadien, erschweren die
differentialdiagnostische Abgrenzung und klare Definition von Studienkohorten in
der wissenschaftlichen Forschung.
Association and Pathways between Dietary Manganese Intake and Incident Venous Thromboembolism
Authors: Huang Yu , Zhang Yanjun , Yang Sisi , Xiang Hao , Zhou Chun , Ye Ziliang , Liu Mengyi , He Panpan , Zhang Yuanyuan , Gan Xiaoqin , Qin Xianhui 
Published: November 2023

Background The association between dietary manganese (Mn) intake and the risk of venous thromboembolism (VTE) remains unknown. We aimed to investigate the associations of dietary Mn intake with incident VTE, and the underlying mediating roles of obesity markers (body mass index [BMI] and waist circumference), hemorheological parameters (red cell distribution width [RDW], platelet count [PLT], and mean platelet volume [MPV]), and inflammatory biomarkers (C-reactive protein [CRP] and white blood cell count [WBC]) in this association.
Methods A total of 202,507 adults from the UK Biobank with complete dietary data and without VTE at baseline were included. Dietary information was collected by the online 24-hour diet recall questionnaires (Oxford WebQ). The primary outcome was incident VTE, a composite of incident deep vein thrombosis (DVT) and pulmonary embolism (PE).
Results During a median follow-up of 11.6 years, 4,750 participants developed incident VTE. Overall, there were significantly inverse relationships of dietary Mn intake with incident VTE (per 1 mg/day increment; adjusted hazard ratio [HR]: 0.92; 95% confidence interval [CI]: 0.90–0.95), incident DVT (per 1 mg/day increment; adjusted HR: 0.93; 95% CI: 0. 90–0.96), and incident PE (per 1 mg/day increment; adjusted HR: 0.91; 95% CI: 0.88–0.95). BMI, waist circumference, RDW, CRP, and WBC significantly mediated the association between dietary Mn intake and incident VTE, with the mediated proportions of 36.0, 36.5, 4.2, 4.3, and 1.6%, respectively. However, MPV and PLT did not significantly mediate the association.
Conclusion Our study shows that dietary Mn intake was inversely associated with incident VTE. The inverse association was mainly mediated by obesity, followed by inflammatory biomarkers and RDW. Our findings are just hypothesis-generating, and further confirmation of our findings in more studies is essential.
Visible-Light-Induced Three-Component Radical Coupling of Selenocarbamates, Enones, and Allylstannanes with Diphenyl (2,4,6-trimethylbenzoyl)phosphine Oxide
Authors: Ishihara Jun , Komine Keita , Yamazaki Yuta , Iwanaga Taiga , Sakaguchi Hikaru , Fukuda Hayato 
Published: November 2023

AbstractA blue LED-induced three-component coupling of a carbamoyl radical, cyclic enone, and allylstannane was developed. The use of blue LEDs and diphenyl(2,4,6-trimethylbenzoyl)phosphine oxide (TPO) as a radical initiator permitted the three-component radical coupling to proceed with a high chemoselectivity. An elucidation of the mechanism revealed a pathway for the formation of a tributyltin radical from TPO and allylstannane. This tandem radical reaction is expected to be applicable in natural-product synthesis.
Trick or treaty? An empirical analysis of the treaty ratification process in Italy
Authors: Vignoli Valerio , Corradi Edoardo 
Published: November 2023

AbstractTreaties are a fundamental tool of international politics. Therefore, existing literature has long investigated their ratification, the act through which an actor commits itself to the treaty’s content and its determinants. However, we believe this scholarship has three substantial limitations: a lack of comprehensive assessments of the differences between bilateral and multilateral treaties, a limited attention to small and middle powers, and a substantial neglect of the impact of cabinet ideology. We address these gaps by exploring the dynamics of treaty ratification in Italy. Our analysis covers all the treaties signed and ratified by Italian policymakers between 1994 and 2022 that underwent parliamentary approval. We find that multilateral treaties take, on average, more time to get ratified than bilateral ones. Treaties regarding areas such as environment and human rights are also subject to longer ratification processes. The presence of left-wing cabinet coalitions tends to increase the likelihood of ratification. Through these findings, the article contributes to the understanding of treaty commitment in middle powers. It also provides an innovative point of view in the debate on Italian foreign policy and its domestic drivers.