bluuebunny/crossref_metadata_2025_split huggingface dataset:
Community effort to unravel the complex human neuronal landscape exemplified for the striatum
Authors: Schultze Joachim , Agrawal Shobhit , Scholz Rebekka , Hartmann Celia , Hetzel Leon , Carraro Caterina , Bernardes Joana , Lautwein Tobias , Reinhardt Susanne , Franitza Marek , Fuss Janina , Schulze-Selting Antje , Heimbach André , Conrad Thomas , Buena-Atienza Elena , Buettner Maren , Elmzzahi Tarek , Pacht Tal , Paulusch Stefan , Wollenweber Tassilo , Kock Sabine , Falk-Paulsen Maren , Roscito Juliana , Czemmel Stefan , Bank Netherlands Brain , Becker Matthias , De-Domenico Elena , Bonaguro Lorenzo , Franzenburg Sören , Koehrer Karl , Casadei Nicolas , Händler Kristian , Dahl Andreas , Huitinga Inge , Altmueller Janine , Nuernberg Peter , Bonifacio Ezio , Rieß Olaf , Rosenstiel Philip , Wieczorek Dagmar , Noethen Markus , Theis Fabian , Ulas Thomas , Beyer Marc 
Published: February 2024

Abstract

Precise determination of cellular identity and molecular phenotypes through advanced high-throughput technologies is crucial for understanding intricate tissue functions, especially in complex organs like the brain. Given the complexity of the brain, community efforts are needed but currently underexploited to unravel the function of the human brain. In this study, we present findings from a multi-center investigation performed as a community effort involving seven genome centers. We analyzed single-nucleus transcriptomes obtained from NeuN+ neurons from the putamen and caudate nucleus of both healthy individuals and Parkinson's Disease (PD) patients. Our results demonstrate the potential for establishing community-wide standards, fostering collaborative networks, and enhancing brain cell classification efforts. We propose a transcriptional architecture that encodes synaptic communication patterns in the striatum, comprising of cell-adhesion molecules (CAMs), transmitter/modulator receptors, ion channels, signaling proteins, neuropeptides, vesicular release components, and transcription factors. This classification serves as a foundation for mapping and integrating publicly available datasets, showcasing the value of deep sampling in defined brain regions for comprehensive brain-wide analyses. Importantly, this nomenclature can serve as a template for other brain regions. This community effort enabled the precise mapping of cellular alterations in Parkinson's Disease. Transcriptional changes predominantly occurred in specific cell states of medium spiny neurons within the putamen matrix, pointing towards increased excitability. Additionally, a disbalance in specific interneuron cell states was associated with heightened glutamatergic signaling, further contributing to increased overall excitability.
A green supply chain transportation network model incorporating multi-stakeholders’ condition using fuzzy game theory
Authors: Darvishsefat Mahmood , Rezaeian Javad , Pourpasha Mohammad Mahdi 
Published: February 2024

Abstract
Companies around the globe, aim to reduce stock, production cycle time, transportation cost, quality cost, to maximize their benefits. This is normally done by using supply chain management principles. There is, also, a raising global awareness around reducing our negative environmental impacts. To this end, this paper proposes a multi-level green supply chain transportation model under multi-stakeholder’s condition, in which fuzzy game and Shapley-Hukuhara value were used to select the best interactive mode by presenting different scenarios so that all stakeholders achieve their maximum benefits. The optimal model includes the lowest costs of purchase and production, maintenance, shortage, and warehousing, while the produced CO2 is minimized at different stages of production and transportation. The results of a numerical case study showed that the answer provided by the game theory for the value of the objective function is less than the ones by the transport problem, despite the deficit penalty.
EcoAgriBot: Harnessing Solar Energy and ESP8266 Connectivity for Precision and Sustainability in Rice Cultivation
Authors: Nebrida Alan , Millares Dhom Ryan S. 
Published: February 2024

Abstract
The EcoAgriBot project aims to tackle the inefficiencies and labor-intensive aspects of conventional rice farming by the use of a solar-powered, remote-controlled Rice Direct Seeder. The gadget, which is meant to improve accuracy and sustainability in rice cultivation, employs solar energy and an ESP8266 Wi-Fi module for intelligent functioning. The development approach included meticulous strategizing, conceptualization, and experimentation to guarantee optimal performance in arid terrain. The EcoAgriBot's field testing revealed its capacity to be controlled over great distances, its efficiency in seed planting, and its significant reduction in manpower requirements. The user comments emphasized the operating speed, cost-effectiveness, and convenience of use of the product, highlighting its potential to bring about a revolution in rice production. The study's findings indicate that the EcoAgriBot is a notable technical progression, providing a sustainable resolution to contemporary agricultural obstacles and laying the groundwork for forthcoming advancements in farming methodologies.
Low Adherence to and Low Sustainability of Weight Loss Among Patients with Non-alcoholic Fatty Liver Disease
Authors: Espino Joseph Nino , Navarroza Ann Margaret C. , Velasco Alvin Brian C. , Romano Rommel , Dalupang Carmelita C. , Dy Frederick T. , Wong Stephen N. 
Published: February 2024

Abstract
Background: Weight loss, though difficult to attain and sustain over time, remains the cornerstone of non-alcoholic fatty liver disease (NAFLD) treatment. We aimed to describe weight changes among NAFLD patients.
Methods: This was a retrospective, cohort study of consecutively-identified NAFLD patients with >2 clinic visits from March2007–April2018. Weight changes from baseline were categorized into weight gain, weight loss, and no change. Baseline liver and metabolic biochemistries and non invasive liver fibrosis tests were correlated with the final weight changes. Succeeding weight changes after the initial follow-up visits were used to determine sustainability of weight loss. Results: Of the 240 patients included, 123 (51.2%), 93 (38.8%), and 24 (10%) had weight gain, weight loss, and no change, respectively. Only 12.5% had >5% weight loss. Duration of follow-up was significantly longer for patients with weight loss (p<0.001). None of the baseline demographic and laboratory data were associated with weight loss. Patients with weight loss also did not have significant changes to their biochemistries and non-invasive liver fibrosis tests compared to patients with weight gain/no change. Compared to patients with weight gain after the initial follow-up, where only 11.8% were able to lose weight on the final visit, 73.1% of patients who lost weight after the initial follow-up were able to sustain their weight loss on the final visit.
Conclusions: Weight loss is achieved in only a third of NAFLD patients. Although 73% of patients who lost weight initially were able to sustain it, patients who gained weight after the 1st follow-up were unlikely to lose weight on further follow-up.
The effect of selective alpha-1 receptor antagonist on arterial stiffness parameters in patients with benign prostate hyperplasia
Authors: Ucar Eda , Lale Elif Nazli , Ozen Enes , Yilmaz Yavuz , Yildirim Cagan , Genc Yunus Emre , Dogan Zekeriya , Gurel Emre , Sener Tarik Emre , Sunbul Murat 
Published: February 2024

Abstract
Purpose
Non-selective adrenergic alpha-1 antagonists have been shown to reduce arterial stiffness. Our aim is to assess effects of selective adrenergic alpha-1 antagonist on arterial stiffness, namely silodosin.
Methods
This prospective study was carried out on 20 patients with recently diagnosed benign prostate hyperplasia. International Prostate Symptom Score calculation, arterial stiffness test with arteriograph and uroflowmetry were performed prior to planned silodosin medical treatment. After initial assessment, patients were given 8 mg of silodosin daily. Initial tests and calculations were repeated after 1 month of follow up. Comparisons between baseline and control data were performed using paired sample t-test and Wilcoxon signed-rank test for normally and non-normally distributed data respectively.
Results
There were significant reduction in International Prostate Symptom Scores of patients before and after silodosin treatment (p < 0.001). There were statistically insignificant reduction of arterial stiffness and increase of maximum flow rate (p = 0.314 and p = 0.053 respectively).
Conclusion
Although arterial stiffness parameters of our patients showed a trend of decrease with usage of silodosin, it did not reach statistical significance.
Ovarian Dysgerminoma Complicating Pregnancy: A Case Report and Review of Management Strategies
Authors: Ghoshim Mona , Rashid Hana'a , Al-Mahdi Maha , Jowah Haitham Mohammed 
Published: February 2024

Abstract
Background: Ovarian dysgerminoma is a rare germ cell tumor that is uniquely challenging to diagnoseduring pregnancy. This case report illustrates the complexity of managing such a condition in a pregnant patient, with a focus on clinical presentation, diagnostic workup, therapeutic options, and patient outcomes.
Case Presentation: A 25-year-old woman, G6P4+1, presented with an 8-month history of amenorrhea and a 2-month history of progressively worsening lower abdominal pain, urine retention, and abdominal distension at 35 weeks of gestation. Upon examination, she was found to have an ovarian mass extending to the cervix. After a multidisciplinary discussion, a lower segment cesarean section was performed to deliver a live female infant, after which the ovarian mass was resected, which was later confirmed to be dysgerminoma with a yolk sac tumor. Diagnosis was established using ultrasound and supported by laboratory findings. The patient underwent surgery due to worsening symptoms, reflecting the urgent need for intervention. Postoperative management was complicated by the patient's refusal to continue with recommended chemotherapy. The patient initially recovered but later developed sudden abdominal distension and sought medical care at a rural facility. Despite the initial treatment, she experienced complications and tragically she passed away.
Conclusion: This case study underscores the importance of a thorough diagnostic approach, timely intervention, and the need for adherence to postoperative chemotherapy in the management of ovarian dysgerminoma during pregnancy. The findings also highlight the necessity of patient education and the potential impact of patient autonomy on treatment outcomes.
Analysis of Genetic Algorithms in Natural Language Processing
Authors: Bahadur Ekagrata 
Published: February 2024

Abstract
Natural language processing (NLP) has increased the interest in genetic algorithm (GA) due to their skills in solving complex optimization problems with extensive research on the use of genetic algorithms in NLP projects has been presented in this paper. First, we present the basic concepts behind genetic algorithms and their relevance to natural language processing. Then, we explore various applications of natural language processing (NLP) that use genetic algorithms, including text classification, sentiment analysis, machine translation, summarization, and question-answering systems. We examine the advantages and disadvantages of genetic algorithm applications in natural language processing by comparing their performance with traditional and modern approaches and discuss the factors influencing their effectiveness. Furthermore, we explore recent advancements, modifications, and hybridizations of Genetic Algorithms tailored to NLP tasks. Finally, we discuss the challenges and future directions in leveraging Genetic Algorithms for enhancing NLP technologies.
Hip-related Functional Limitations in Individuals With Idiopathic Scoliosis: a Controlled Trial
Authors: ÇELİK Fatih , ŞENOL Burcu , DEMİRKIRAN Gökhan , BEK Nilgün , YAKUT Yavuz , YAĞCI Gözde 
Published: February 2024

Abstract
Background Since scoliosis is a three-dimensional deformity, it causes some movement limitations in the spine and related joints. However, functional limitations associated with scoliosis-related hip joint involvement are the subject of research.Aims This study aims to investigate the physical characteristics and functional limitations associated with idiopathic scoliosis (IS), focusing on hip joint.Methods Participants with IS and a control group were assessed using manual goniometry for hip joint RoM, indirect methods for lumbar mobility, the Foot Posture Index (FPI) for foot posture, the Trendelenburg sign within the single leg squat (SLS) test for muscle strength, the Y-Balance test (YBT) for balance, the hip joint position sense (JPS) test for proprioception, and the Lower Extremity Functional Scale (LEFS) for functional status.Results Individuals with scoliosis exhibited limitations in hip joint RoM, particularly in flexion, extension, abduction, adduction, and internal rotation compared to controls.Lumbar mobility was reduced in the scoliosis group. The SLS and Y-Balance tests showed decreased scores in the posterior direction. Scoliosis participants had a tendency towards pronated foot posture. Hip JPS did not differ significantly between the groups. Muscle strength, as indicated by the Trendelenburg sign, was weaker in the scoliosis group. LEFS scores were lower in the scoliosis group but lacked clinical significance.Conclusion However, the observed differences were relatively small and may not have significant clinical implications. Future research should consider specific curve patterns of scoliosis and employ more advanced measurement techniques for enhanced reliability.
A inserção das abordagens microética e macroética no ensino de engenharias: Uma breve revisão sistemática da literatura
Authors: Lemos Pedro Bruno Silva , Jucá Sandro César Silveira , Da Silva Solonildo Almeida 
Published: February 2024

Esse estudo examina, por meio de uma revisão sistemática da literatura, a produção científica acerca da inserção das abordagens de ensino microética e macroética nas engenharias. A partir da análise de vinte e seis (26) artigos científicos e trabalhos publicados em anais de eventos internacionais, observou-se o aumento da publicação de trabalhos sobre a utilização das mencionadas abordagens no ensino de engenharias nos anos de 2015 e 2019. A análise dos trabalhos selecionados evidenciou que a abordagem microética é caracterizada pela ênfase em tópicos relacionados às responsabilidades individuais decorrentes da atuação profissional do engenheiro. Os resultados, ainda, possibilitaram identificar que a abordagem macroética é centrada em considerações profissionais mais amplas e relacionadas aos impactos sociais e ambientais decorrentes da realização de projetos e empreendimentos de engenharias. Foi identificada, em adicional, que os contextos nacionais contribuem para a existência de diferentes configurações do modelo de ensino das abordagens micro e macroética em cursos de engenharias. Por fim, a revisão da literatura atestou o maior quantitativo de estudos que relacionavam o enfoque Ciência Tecnologia e Sociedade (CTS) e a Filosofia da Tecnologia à inserção de discussões e conteúdos de caráter macroético nas engenharias.
The Role and Therapeutic Potential of Non-coding RNAs in Resistance to EGFR-TKIs targeted therapy for Non-small Cell Lung Cancer
Authors: Zhang Yang , Chen Ye , Lu Li-Li , Xie Xiu-Li , Huan Ren , Wu Li-Fang , Tan Li-Na , Xu Tao , Jin Yong 
Published: February 2024

Abstract:
Lung cancer is the leading cause of cancer-related deaths worldwide, of
which non-small cell lung cancer (NSCLC) is the most common type, and epidermal
growth factor receptor tyrosine kinase inhibitors (EGFR-TKIs) are widely used for the
treatment of NSCLC. EGFR-TKIs are known to develop a drug-resistant response after
a certain number of cycles of dosing, and how to alleviate or even reverse EGFR-TKI resistance
is an urgent problem at present. This review focuses on the role of ncRNAs in
the resistance of NSCLC to EGFR-TKIs and the potential mechanisms underlying the
development of NSCLC resistance to EGFR-TKIs. NcRNAs are involved in NSCLC resistance
to EGFR-TKIs by mediating cellular drug efflux, epithelial-mesenchymal transition,
apoptosis, autophagy, and EGFR mutation. ncRNAs play a crucial role in NSCLC
resistance to EGFR-TKIs. Hopefully, the results will provide some guidance and help
for the treatment and prognosis of NSCLC.
Antihistamines, Proton Pump Inhibitors and Related Drugs
Authors: Faruk Khan M. O. 
Published: February 2024

This chapter is a comprehensive account of the medicinal chemistry of
antihistamines, H2
receptor (H2R) blockers, H3
receptor (H3R) blockers, and proton
pump inhibitors (PPIs). It provides the mechanism of drug action and detailed
structure-activity relationship (SAR) of the drugs in these classes to give the
knowledge base for pharmacists. After studying this chapter, students will be able to:• Describe the physiochemical properties of histamine and histamine receptors.
• Identify chemical classifications and describe the SAR of antihistamines, H2R and
H3R antagonists.
• Differentiate receptor binding patterns and structural features between histamine
receptor agonists and antagonists.
• Distinguish between sedating and non-sedating antihistamines, as well as the first-,
second- and third-generation antihistamines.• Describe the structural features of cromolyn and related mast cell stabilizers and their
therapeutic applications.
• Discuss the proton pump inhibitors, including their development, mechanism of
action, and structural and physicochemical features.
• Apply the medicinal chemistry principles to the clinically relevant case studies.
• Explain the drug discovery story of representative drugs of different classes.
Hormoneal Therapy
Authors: Faruk Khan M. O. , Llayton Chelsey 
Published: February 2024

Treatments that involve the use of hormones or their antagonists are
commonly referred to as hormone therapy or hormonal therapy. Oncologic hormone
therapy, hormone replacement therapy (HRT), androgen replacement therapy (ART),
oral contraceptive pills and gender-affirming hormone therapy are the major classes of
hormonal therapy in addition to a few others. Some hormonal therapies will be
discussed in detail under different chapters including oncologic hormone therapy,
glucocorticoids and mineralocorticoids and insulin under antineoplastic agents, antiinflammatory steroids and antidiabetic agents, respectively. After studying this chapter,
students will be able to:
• Define and classify hormonal therapy and differentiate between hormonal therapy and
treatment.
• Explain all types of hormone replacement therapy including menopausal, androgens,
and oral contraceptives.• Discuss the use of androgen replacement therapy (ART) in males with low levels of
testosterone due to disease or aging.
• Describe gender-affirming hormone therapy such as feminizing hormone therapy and
masculinizing hormone therapy.
• Identify appropriate growth hormone therapy for growth hormone deficiency.
• Demonstrate understanding of thyroid hormone replacement in hypothyroidism and
antithyroid therapy in hyperthyroidism.
• Demonstrate clear guidance to the use of oral contraceptive pills for various purposes
including birth control.
The Prostanoids
Authors: Faruk Khan M. O. , Murphy Karrie 
Published: February 2024

This chapter is a comprehensive account of the medicinal chemistry of drugs
arising from structural modifications of prostanoids, which are naturally occurring
eicosanoids. These drugs are used for a variety of diseases including but not limited to
glaucoma, pulmonary arterial hypertension, and peptic ulcers. This chapter provides the
mechanism of drug action and structure-activity relationships (SAR) of these drugs.
After studying this chapter, students will be able to:
• Describe the historical background of prostanoids as clinical agents.
• Explain the structure, functions, classifications and biosynthesis of eicosanoids.
• Discuss in detail the chemistry and SAR of the prostanoids involved in the treatment
of glaucoma, pulmonary arterial hypertension, peptic ulcer, and other diseases.• Delineate the clinical significance and therapeutic evaluations of these classes of
drugs by solving case studies.
• Explain the discovery process of latanoprost and zafirlukast.
Tobacco Smoking or Nicotine Phenotype and Severity of Clinical Presentation at the Emergency Department (SMOPHED): Protocol for a Noninterventional Observational Study
Authors: Campagna Davide , Farsalinos Konstantinos , Costantino Giorgio , Carpinteri Giuseppe , Caponnetto Pasquale , Cucuzza Francesca , Polosa Riccardo ,   SMOPHED Study Group
Published: February 2024

Background
In the last few years, several nicotine products have become available as alternatives to smoking tobacco. While laboratory and limited clinical studies suggest that these devices are less toxic compared to classic tobacco cigarettes, very little is known about their epidemiological impact. Visiting the emergency department (ED) often represents the first or even the only contact of patients with the health care system. Therefore, a study conducted at the ED to assess the impact of these products on health can be reliable and reflect a real-life setting.

Objective
The aim of this noninterventional observational study (SMOPHED study) is to analyze the association between the severity of clinical presentation observed during ED visits among patients using various nicotine products and the subsequent outcomes, specifically hospitalization and mortality.

Methods
Outcomes (hospitalization and mortality in the ED) will be examined in relation to various patterns of nicotine products use. We plan to enroll approximately 2000 participants during triage at the ED. These individuals will be characterized based on their patterns of tobacco and nicotine consumption, identified through a specific questionnaire. This categorization will allow for a detailed analysis of how different usage patterns of nicotine products correlate with the clinical diagnosis made during the ED visits and the consequent outcomes.

Results
Enrollment into the study started in March 2024. We enrolled a total of 901 participants in 1 month (approximately 300 potential participants did not provide the informed consent to participate). The data will be analyzed by a statistician as soon as the database is completed. Full data will be published by December 2024.

Conclusions
There is substantial debate about the harm reduction potential of alternative nicotine products in terms of their smoking-cessation and risk-reduction potential. This study represents an opportunity to document epidemiological data on the link between the use of different types of nicotine products and disease diagnosis and severity during an ED visit, and thus evaluate the harm reduction potential claims for these products.

International Registered Report Identifier (IRRID)
PRR1-10.2196/54041