bluuebunny/crossref_metadata_2025_split huggingface dataset:
A context-aware framework for recommendation-based adaptive user interfaces in Smart Product-Service System
Authors: Carrera-Rivera Angela , Larrinaga Felix , Lasa Ganix , Martinez-Arellano Giovanna , Unamuno Gorka 
Published: February 2024

Abstract

Smart Product-Service Systems (S-PSS) represent an innovative business model that integrates intelligent products with advanced digital capabilities and corresponding e-services. The User Experience (UX) within an S-PSS is heavily influenced by the individualization of services and customer empowerment. However, conventional UX analysis primarily focuses on the design stage and may not adequately respond to the evolving user needs during the usage stage and how to exploit the data surrounding the use of S-PSS. To overcome these limitations, this article introduces a practical framework for developing adaptive user interfaces within S-PSS. This framework integrates ontologies and context-aware recommendation systems, with user interactions serving as the primary data source, facilitating the development of adaptive user interfaces. One of the main contributions of this work lies on the integration of various components to achieve the creation of adaptive user interfaces for digital services. A case study of a smart device app is presented, to demonstrate the practical implementation of the framework, with a hands-on development approach, considering technological aspects and utilizing appropriate tools. The results of the evaluation of the recommendation engine show that using a context-aware approach improves the precision of recommendations. Furthermore, pragmatic aspects of UX, such as usefulness and system efficiency, are evaluated with participants with an overall positive impact on the use of the smart device.
Decoding functional hematopoietic progenitor cells in the adult human lung
Authors: Conrad Catharina , Magnen Melia , Tsui Jessica , Wismer Harrison , Naser Mohammad , Venkataramani Urmila , Samad Bushra , Cleary Simon J , Qiu Longhui , Tian Jennifer J , De Giovanni Marco , Mende Nicole , Passegue Emmanuelle , Laurenti Elisa , Combes Alexis J , Looney Mark R 
Published: February 2024

Abstract
The bone marrow is the main site of blood cell production in adults, however, rare pools of hematopoietic stem and progenitor cells with self-renewal and differentiation potential have been found in extramedullary organs. The lung is primarily known for its role in gas exchange but has recently been described as a site of blood production in mice. Here, we show that functional hematopoietic precursors reside in the extravascular spaces of the human lung, at a frequency similar to the bone marrow, and are capable of proliferation and engraftment. The organ-specific gene signature of pulmonary and medullary CD34+ hematopoietic progenitors indicates greater baseline activation of immune, megakaryocyte/platelet and erythroid-related pathways in lung progenitors. Spatial transcriptomics mapped blood progenitors in the lung to a vascular-rich alveolar interstitium niche. These results identify the lung as a pool for uniquely programmed blood stem and progenitor cells with the potential to support hematopoiesis in humans.
Multi-cohort cerebrospinal fluid proteomics identifies robust molecular signatures for asymptomatic and symptomatic Alzheimer’s disease.
Authors: Cruchaga Carlos , Ali Muhammad , Shen Yuanyuan , Do Anh , Wang Lihua , Western Daniel , Liu Menghan , Beric Aleksandra , Budde John , Gentsch Jen , Schindler Suzanne , Morris John , Holtzman David , Fernández Maria , Ruiz Agustín , Alvarez Ignacio , Aguilar Miquel , Pastor Pau , Rutledge Jarod , Oh Hamilton , Wilson Edward , Guen Yann Le , Khalid Rana , Robins Chloe , Pulford David , Ibanez Laura , Wyss-Coray Tony , Sung Yun Ju 
Published: February 2024

Abstract
Changes in Amyloid-β (A), hyperphosphorylated Tau (T) in brain and cerebrospinal fluid (CSF) precedes AD symptoms, making CSF proteome a potential avenue to understand the pathophysiology and facilitate reliable diagnostics and therapies. Using the AT framework and a three-stage study design (discovery, replication, and meta-analysis), we identified 2,173 proteins dysregulated in AD, that were further validated in a third totally independent cohort. Machine learning was implemented to create and validate highly accurate and replicable (AUC>0.90) models that predict AD biomarker positivity and clinical status. These models can also identify people that will convert to AD and those AD cases with faster progression. The associated proteins cluster in four different protein pseudo-trajectories groups spanning the AD continuum and were enrichment in specific pathways including neuronal death, apoptosis and tau phosphorylation (early stages), microglia dysregulation and endolysosomal dysfuncton(mid-stages), brain plasticity and longevity (mid-stages) and late microglia-neuron crosstalk (late stages).
Probing Electromagnetic Nonreciprocity with Quantum Geometry of Photonic States
Authors: Petrides Ioannis , Curtis Jonathan , Wesson Marie , Yacoby Amir , Narang Prineha 
Published: February 2024

Abstract

Reciprocal and nonreciprocal effects in dielectric and magnetic materials provide crucial information about the microscopic properties of electrons. However, experimentally distinguishing the two has proven to be challenging, especially when the associated effects are extremely small. To this end, we propose a contact-less detection using a cross-cavity device where a material of interest is placed at its centre. We show that the optical properties of the material, such as Kerr and Faraday rotation, or, birefringence, manifest in the coupling between the cavity's electromagnetic modes and in the shift of their resonant frequencies. By calculating the dynamics of a geometrical photonic state, we formulate a measurement protocol based on the quantum metric (and quantum process tomography) that isolates the individual components of the material's complex refractive index and minimizes the quantum mechanical Cramer-Rao bound on the variance of the associated parameter estimation. Our approach is expected to be applicable across a broad spectrum of experimental platforms including Fock states in optical cavities, or, coherent states in microwave and THz resonators.
Repeatability and reproducibility of VR in automated measurement and diagnosis of strabismus
Authors: Fu Jing , Wang Yumeng , Liu Jiawen , Chen Weiwei , Jiang Meixia 
Published: February 2024

Abstract

Background To explore the accuracy and reproducibility of VR technology for strabismus screening.Methods In this cross-sectional study, a total of 191 subjects were included. Examinations included VR technology based on infrared, the cover-uncover test, and the prism alternating cover test (PACT) at various gaze positions, specifically at distances of 33cm and 6m. The accuracy of VR in diagnosing strabismus and quantifying the degree of strabismus was evaluated by comparing the VR results to the average outcomes of manual examinations conducted by the two physicians, considered the gold standard.Results A total of 88 healthy individuals, 81 exotropia patients, 17 esotropia patients, and 5 vertical strabismus patients were included in this study, and each subject was screened for less than 2 min. The sensitivity of VR for screening strabismus was 80.3% and the specificity was 80%, displaying moderately consistent with the manual results (Kappa = 0.598, p < 0.001). The sensitivity for diagnosing exotropia was 76.5% and the specificity was 91.8%, also showing strong agreement with the manual results (Kappa = 0.695, p < 0.001). The sensitivity for diagnosing esotropia was 94.1% and the specificity was 95.4%, with strong agreement with the manual results (Kappa = 0.755, p < 0.001). The sensitivity for diagnosing vertical strabismus was 80% and the specificity was 98.9%, with strong agreement with manual results (Kappa = 0.719, p < 0.001). Reproducibility of VR compared to manual results, expressed as intraclass correlation efficient (ICC), was moderately reproducible for exotropia in near mode (ICC = 0.587, range, -0.036-0.826) and less reproducible for exotropia in far mode (ICC = 0.349, range, -0.042-0.615). ICC was highly reproducible (ICC = 0.701, range,0.358–0.879) for the esotropic far mode results (6m) and not statistically significant for the esotropic near mode results (33cm). ICC was moderately reproducible (ICC = 0.606, range, -0.143-0.946) for the vertical-near-mode results (33cm) and not statistically significant for the vertical-far-mode results (6m).Conclusions This novel technique for strabismus screening, which utilizes virtual reality technology, enables quick, precise, and straightforward diagnosis of strabismus. It has also shown notable efficacy in accurately measuring the angle of deviation in cases of exotropia.
Detection of PD-L1 Expression and Its Clinical Significance in Circulating Tumor Cells from Patients with Hypopharyngeal and Laryngeal Cancers (HLC)
Authors: Li Chen , Zhu Hongyu , Lin Qin , Chen Wei , Huang Xiaoting , Wang Desheng 
Published: February 2024

Abstract
Programmed death ligand 1(PD-L1) plays a pivotal role as an immunoregulatory checkpoint within the immune system, exerting a critical influence on the internal functioning and survival mechanisms of cancer cells. Our study aimed to elucidate the clinical significance of PD-L1 expression in circulating tumor cells (CTCs) derived from individuals afflicted with Hypopharyngeal and Laryngeal Cancers (HLCs), as well as its potential implications for clinical practice. CTC were identified using an immunomagnetic positive sorting methodology. The sensitivity and specificity of this sorting system were evaluated through infrared, ultraviolet, particle size and electrostatic potential evaluations. Additionally, in vitro analyses were conducted to assess the binding proficiency and cytotoxic impact of immunolipid magnetic nanobeads. Simultaneous detection was conducted on the CTC levels among PD-L1-positive patients, aiming to ascertain the dynamic relationship between real-time CTC fluctuations and the clinicopathological indices of the patients. The constructed immunolipid magnetic nano-beads demonstrated pronounced efficacy in capturing circulating tumor cells (CTCs), and the lipid nanoparticles exhibited noteworthy capture efficiency coupled with minimal cytotoxic effects. This investigation encompassed a cohort exceeding 30 individuals, wherein PD-L1 expression analysis was executed to delineate CTC variations within PD-L1-positive patients, thereby yielding auxiliary insights for clinical diagnosis. Subsequent assessment of PD-L1 expression consistency between CTCs and tissue specimens revealed a substantial agreement surpassing 70%. Furthermore, inhibition of PD-L1 yielded a significant elevation in the cytokine TNF-α levels, accompanied by a concomitant reduction in IL-10 levels. The CTC sorting system devised in this investigation boasts attributes of remarkable specificity and sensitivity. Serving as a viable substitute when procuring tissue samples is arduous, this system partly mitigates the challenge of accessing tumor tissues. By virtue of PD-L1 expression analysis, it holds the potential to offer instructive implications for tailoring individualized treatments in clinical scenarios.
Drug Prescription Awareness Among Dental Students in Kerala: a Survey of Current Knowledge and Awareness
Authors: V Syam Kumar , Rajeev Gayathri , M Anwar , Krishna Archana , P Anju , Raj Anitta C 
Published: February 2024

Abstract
Background: Prescribing medicine is a core skill for dentists, impacting patient safety and requiring knowledge of medications, dosages, and risks. This study evaluates dental students' awareness of these critical aspects in Kerala, India.
Objective: This study aimed to assess drug prescription awareness among dental students in Kerala, India, highlighting current knowledge, standard practices, and areas for improvement.
Methods: We actively recruited 300 final-year BDS students and dental house surgeons from various colleges throughout Kerala to participate in a cross-sectional survey. The participants actively completed a validated questionnaire that assessed their drug prescription practices, knowledge of common conditions and medications, and preferred information sources. Descriptive statistics and inferential analyses were then actively employed to evaluate the collected data.
Results: Dental pain emerged as the most commonly treated condition (57.7%), with Amoxicillin reigning as the antibiotic of choice (69.2%-76.3%). Textbooks reigned supreme as the primary source of prescription information (66.4%-58.3%), even as most participants (78.1%-72.4%) acknowledged the WHO prescribing guidelines. While interns demonstrably boasted greater confidence in their knowledge, nearly half of all participants grappled with a lack of confidence in drug dosage and frequency. Incorrect dosage stood out as the Achilles' heel of prescription practices (71.9%-77.6%). Strengths included awareness of the correct route of delivery (61.6%-74.4%) and adherence to WHO guidelines.
Conclusion: Dental students in Kerala demonstrate fair drug prescription awareness but have gaps in knowledge regarding dosage, frequency, and duration. Textbooks are the primary information source, highlighting the need for more in-depth education and reliance on evidence-based resources. Targeted interventions focused on these areas could enhance prescribing practices and patient safety.
Clinical relevance: A clear understanding of drug prescription forms an essential foundation of clinical practice among future dental practitioners. Assessing this is necessary to form corrective measures in our education system that ensure sufficient and succinct therapeutic practices.
Green Synthesis of Zinc Oxide Nanoparticles from Allium cepa Skin: Photocatalytic Degradation and Antibacterial Properties
Authors: Sowjanya Bandela , King Pulipati , Vangalapati Meena , Myneni Venkata Ratnam 
Published: February 2024

Abstract
The present study uses a bio-waste i.e., skin of Allium cepa, for green synthesis of zinc oxide nanoparticles. The nanoparticles A.Cepa-ZnONP were tested for their photo catalytic degradation efficacy towards harmful dyes. Additionally, the anti-bacterial properties of A.Cepa-ZnONP were evaluated against four organisms, namely Escherichia coli (EC), Pseudomonas aeruginosa (PA), Bacillus cereus (BC), and Staphylococcus aureus (SA). The synthesized A.Cepa-ZnONP was characterized with scanning electron microscopy-energy dispersive X-ray spectroscopy (SEM-EDX), X-ray diffraction (XRD), and Fourier-transform infrared spectroscopy (FTIR) methods. The A.Cepa-ZnONP demonstrated efficient degradation of Crystal Violet (CV), Rhodamine B (RB), and Methylene blue (MB) dyes, achieving maximum degradation percentages of 99.21%, 95.63%, and 92.34%, respectively, while operating under optimal process conditions. The rate constant values for CV, RB, and MB dyes at a temperature of 328K were determined to be 0.1063, 0.0758, and 0.0447 min-1, respectively. The activation energy values for CV, RB, and MB dyes were determined to be 12.28, 18.437, and 50.623 kJ/mol, respectively. The successful regeneration of photo catalytic material A.Cepa-ZnONP is a crucial milestone in guaranteeing their long-term effectiveness and practical usability.
Zinc finger transcription factor FoZfp1 is required for growth, conidiation, osmoregulation, and full virulence in the Polygonatum kingianum pathogen Fusarium oxysporum
Authors: Su Jianyun , Wang Jingyi , Tang Jingying , Yu Weimei , Liu Jiajia , Dong Xian , Dong Jiahong , Chai Xia , Ji Pengzhang , Zhang Lei 
Published: February 2024

Abstract
Polygonatum kingianum rhizome rot is a destructive soil-borne disease caused by Fusarium oxysporum, which adversely affects the yield and sustainable development of P. kingianum. However, there are few effective control measures against rhizome rot. Thus, understanding the infection mechanism of F. oxysporum is essential to manage rhizome rot in P. kingianum effectively. In this study, zinc finger transcription factor FoZfp1 consisting of two C2H2 motifs was up-regulated during F. oxysporum conidial germination. The FoZfp1 gene deletion mutant (△FoZfp1) and the mutant complementary (△FoZfp1-C) strains were generated by the target gene replacement technique. Biological characteristic analyses revealed that the △FoZfp1 mycelial growth and conidial production were slower than those of the wild-type F. oxysporum (WT) and △FoZfp1-C. Additionally, the inhibition rates and sensitivity of △FoZfp1 under cell wall and osmotic targeted stresses were decreased compared to those of WT and △FoZfp1-C. Pathogenicity assays further revealed that the virulence of △FoZfp1 on the P. kingianum leaves and rhizomes was significantly reduced. These results indicate that FoZfp1 is associated with mycelial growth, conidiation, osmoregulation, and pathogenicity in F. oxysporum on P. kingianum.
Delineating Plio-Pleistocene channels (gas reservoirs) via seismic attributes in Baltim Gas Field, Nile Delta, Egypt
Authors: EL-SAYED Ali , Mohamed Walid , Mohsen Ahmed 
Published: February 2024

Abstract

The offshore Nile Delta's Baltim gas fields contain extremely substantial gas condensate accumulations. Therefore, defining Pleistocene reservoirs (El-Wastani formation) and Pliocene reservoirs (Kafr El-Sheikh formation) is the primary objective of this research. A variety of data from five wells, such as gamma-ray, density, neutron, sonic, and resistivity wireline logs. These well logs are put together with seismic data, and a synthetic seismogram is used to find the right gas horizon interpretation for both of anomalies. Using seismic attributes while looking the existing seismic data makes it much easier for interpreters to learn more about the existing geological features. This investigation primarily aims to verify the presence of two potential gas anomalies, first is the structural attributes which include by applying seismic attributes in addition to conventional seismic interpretation. Seismic attributes are significant to ensure the two prospective gas anomalies by applying two different types of seismic attributes. First is the structural attributes which include discontinuity and fault likelihood (FLH), which are very important for fault detection. They are also important for examining the gas leakage to determine if the main fault is fully sealed, partially sealed, or non-sealed. The second is stratigraphic attribute, with different types. In this study, three stratigraphic attributes were applied: sweetness, reflection strength, which is a good tool for gas identification as high sweet points and high reflectivity; also, the third type of attribute is spectral decomposition, which is a good type for channel identification and determine of channel fairway as existence in the second Pliocene anomaly, which reflects the best place for drilling development wells. This study area is illustrated through seismic interpretation of 3D re-processed seismic data collected in 2018 and 5 wells data.
Evaluation of the Utility of the Renal Angina Index for the Early Diagnosis of Severe Acute Kidney Injury in Critically Ill Pediatric Patients in Three Institutions in Low-Resource Country
Authors: Flórez Jennifer Morantes , Bernal Kasey Fuentes , Piñeres-Olave Byron , Peña Oscar , Fernandez Mauricio , Montoya Francisco , Alvarez Eliana Maria , Jaramillo-Bustamante Juan Camilo 
Published: February 2024

Abstract

Background: Acute kidney injury (AKI) occurring in up to 30% of children admitted to the intensive care unit. Creatinine is the primary functional marker for AKI; however, its utility in early diagnosis is limited. The renal angina index (RAI) has proven to be an effective predictive model for early injury, with limited evidence in Colombia regarding its performance.
Methods: Prospective, analytical, multicenter diagnostic test study in critically ill children in three pediatric intensive care units (PICUs) in Medellín, Colombia. We assess the diagnostic utility of the positive RAI as an early predictor of severe AKI.
Results: Between August 2022 and February 2023, 191 patients were analyzed. The incidence of AKI was 12.5/100 patients, 26% exhibited a positive RAI, 12.6% developed severe AKI at 72 hours. Among RAI-positive patients when comparing with negative, 75% experienced severe AKI (RR 3.23; 95% CI 1.61-6.49), 14% required renal support therapy (RR 2.09; 95% CI 0.95-4.59), and 8% died within 28 days (p=0.964). The sensitivity of RAI for early diagnosis of severe AKI was 85.71%, specificity 78.3%, PPV 24%, NPV 98.5%, AUC 0.812 (95% CI 0.72-0.92). To the patients with a doubled baseline creatinine, 33% developed AKI at 72 hours (RR 1.45; 95% CI 1.09-1.92).
Conclusions: The RAI proved to be a marker for early prediction of severe AKI in critically ill children, potentially serving as a useful tool to improve outcomes related to the presence of AKI compared to the isolated use of creatinine.
Bacillus Intervention: Microbial Ecological Mechanisms for Controlling Root Rot in Coptis chinensis Franch
Authors: Liao Hailang , Ke Wenjia , Chen Sixun , Dong Jijing , Liao Wan , Xu Binjie , Zhou Tao , Ma Yuntong 
Published: February 2024

Abstract

Background:
Coptis root rot (CRR) poses a significant threat to the yield and medicinal quality of Coptis chinensis (Cc), primarily attributed to the presence of Fusarium. This study investigates the potential of four Rhizosphere Bacillus bacteria as biological control agents to combat CRR. These bacteria, namely B. mycoides LB-021, B. pseudomycoides YEM-005, B. velezensis JM-1, and B. subtilis TR-064, were sourced from the rhizosphere of Cc roots. While their antagonistic efficacy has been demonstrated in controlled environments, the translation of their capabilities to field conditions and their impact on the microecological balance within Coptis roots require further exploration.
Results:
Bacillus introduction significantly reconfigures Cc root microbial communities, simplifying the network. Genera enrichment (Arthrobacter, Sphingobium, Pseudomonas, etc.) and Flavobacterium/Gemmatimonas reduction promote plant growth, disease resistance, and soil health. Bacillus triggers antibiotic synthesis (ansamycin, macrolides, etc.), fortifying plant defence against pathogens. Correlations with transcriptome/metabolome highlight Bacillus's influence on root genetics/chemistry. KEGG analysis reveals Bacillus impact on critical plant metabolic pathways.
Conclusions
In conclusion, this study delves into the dynamic relationship between plants and microorganisms in their natural environment, specifically focusing on the role of microbial communities in the rhizosphere. The introduction of Bacillus has a profound impact on the composition and behaviour of the root microbial community, enriching beneficial genera and inducing the synthesis of antibiotics and metabolites that enhance the defence ability of plants. The research emphasizes Bacillus's pivotal role in shaping molecular and metabolic responses, suggesting its eco-friendly potential in enhancing plant disease resistance as an alternative to chemical pesticides.