bluuebunny/crossref_metadata_2025_split huggingface dataset:
Perencanaan Sewerage System dan Instalasi Pengolahan Air Limbah (IPAL) Domestik Kawasan Universitas Malahayati Dengan System Wastewater Garden
Authors: Pradana Angga Arya , Wulandari Diah Ayu , Temenggung Muhtadi Arsyad 
Published: February 2025

Malahayati University is one of the private universities in the city of Bandar Lampung every year receiving thousands of students. All domestic wastewater originating from the Malahayati University area has not been technically treated. The purpose of this research is to be able to plan a domestic Wastewater Treatment Plant (IPAL) in the Malahayati University Area that produces wastewater output in accordance with quality standards, Minister of Environment Regulation No. 68 of 2016 concerning domestic wastewater quality standards. The research method used is descriptive method and literature study with theoretical basis and wastewater concentration in Permen LHK No 68 of 2016 concerning domestic wastewater quality standards.Based on the research, the wastewater generated is 720 m3/day, the planned sewerage is 4 segments. In the weighting matrix of the three alternatives, Wastewater Garden was chosen as the WWTP processor, the land area for WWTP development was 758 m2. From the plan, it was obtained the estimated effluent, BOD 2.8 mg/lt, COD : 4 mg/lt, TSS : 3.2 mg/lt. while the Budget needed to build costs is Rp 1.551.813.000,00.
ABSTRAK
Universitas Malahayati merupakan salah satu Perguruan Tinggi Swasta di kota Bandar Lampung setiap tahunya menerima ribuan mahasiswa, Semua air limbah domestik yang berasal dari kawasan Universitas Malahayati belum dilakukan pengolahan teknis. Tujuan dari penelitian ini adalah dapat merencanakan Instalasi Pengolahan Air Limbah (IPAL) domestik di Kawasan Universitas Malahayati yang menghasilkan output air limbah sesuai dengan baku mutu, Peraturan Menteri Lingkungan Hidup No 68 Tahun 2016 tentang baku mutu air limbah domestik. Metode penelitian yang dipakai metode deskriptif dan studi literatur dengan dasar teori dan konsentrasi air limbah pada Permen LHK No 68 tahun 2016 tentang baku mutu air limbah domestik. Berdasarkan penelitian air limbah dihasilkan sebesar 720 m3/hari, Saluran air limbah yang direncanakan sebanyak 4 segmen. Dalam matriks pembobotan dari tiga alternatif, terpilih Wastewater Garden sebagai pengolah IPAL, didapatkan luas lahan pembangunan IPAL sebesar 758 m2. Dari perencanaan tersebut didapatkan perkiraan effluent, BOD 2,8 mg/lt, COD: 4 mg/lt, TSS: 3,2 mg/lt. sedangkan Anggaran Biaya yang butuhkan untuk membangun biaya sebesar Rp 1.551.813.000,00.
Analisis Stakeholders Dalam Pengelolaan Daerah Aliran Sungai Bedadung Kabupaten Jember
Authors: Murdiyanto Adhitya Ferdiansyah 
Published: February 2025

Kerusakan DAS disamping faktor perubahan tata guna lahan disebabkan lainya oleh masalah institusi, hukum dan kelembagaan yang belum mengatur pada daerah aliran sungai (Nugroho, 2003) dalam (Mulyawan et al., 2022). DAS Bedadung merupakan salah satu 109 DAS Prioritas Nasional dengan kondisi daya dukung DAS Bedadung termasuk dalam kategori yang daya dukung yang di pulihkan (Wibisono, 2021). Dalam kurun waktu tahun 2019-2022 telah terjadi 141 kejadian bencana banjir di wilayah DAS Bedadung Kabupaten Jember. Kurangnya keseriusan pemerintah dalam pengelolaan DAS Bedadung Jember terlihat dari belum adanya dokumen perencanaan lintas sektor RPDAST dan rencana kontijensi DAS Bedadung. Karena banyaknya insttusi yang mengelola DAS Bedadung menimbulkan permasalahan dari perencanaan, pelaksanaan dan evaluasi DAS. Tujuan penelitian ini adalah mengkaji bagaimana peran setiap stakeholders dalam pengelolaan DAS Bedadung. Metode yang digunakan dalam penelitian ini menggunakan deduktif kualitaf. Metode analisis yang digunakan menggunakan analisis pemetaan aktor atau analisis stakeholders dengan dua variabel yakni tingkat kepentingan dan tingkat pengaruh. Tingkat kepentingan stakeholders diukur dengan menggunakan 4 indikator, sedangkan tingkat pengaruh diukur dengan menggunakan 3 indikator. Berdasarkan identifikasi stakeholders tersebut terdapat empat kategori stakeholders dengan 11 stakeholders yang berpengaruh dalam pengelolaan DAS Bedadung. Hasil dari analisis stakeholders dapat ditemukan empat kategori stakeholders yang paling berpengaruh adalah key player yang berasal dari BPDASHL Brantas Sampean, Cabang Dinas Kehutanan Jember dan Perhutani Kabupaten Jember. Di perlukannya upaya kolaborasi lintas sektor dalam pengelolaan DAS Bedadung dan di perlukannya koordinasi, integrasi sinkronisasi dan sinergi dalam pengelolaan DAS.
Analisis Perkembangan Wilayah Menggunakan Permodelan Citra VIIRS Night-Time Light Pada Kabupaten Jember
Authors: P Prasetiyo , Listyawati Ratih Novi , Fitriah Lailatul , Pratama Dhani Malik 
Published: February 2025

Mengidentifikasi perkembangan wilayah dapat dilakukan dengan menggunakan berbagai pendekatan. Umumnya, tingkat perkembangan wilayah dilakukan dengan mentapkan pusat pertumbuhan menggunakan analisis Indeks Sentralitas dengan mempertimbangkan jumlah fasilitas, infrastruktur yang disesuaikan dengan kondisi masyarakat untuk menentukan hierarki pusat daerah. Namun, terdapat keterbatasan dengan Indeks Sentralitas, terutama ketepatan temporal dan spasial, karna mengacu pada data sensus yang tidak mewakili seluruh area secara real-time. Untuk itu, terdapat inovasi dalam melihat perkembangan wilayah menggunakan metode Visible and Infrared Imaging Radiometer Suite (VIIRS), yang merupakan salah satu instrumen di Suomi-NPP (National Polar-orbiting Operational Environmental Satellite System Preparatory Project). Metode VIIRS memanfaatkan cahaya di malam hari karna adanya aktivitas masyarakat. Data tersebut selanjutnya diklasifikasikan menjadi delapan interval kelas di mana semakin besar angka kelas, semakin besar intensitas emisi cahaya dan dengan demikian semakin aktif penduduknya. Hasil analisis menunjukkan bahwa kecamatan dengan tingkat perkembangan wilayah tertinggi berada pada Kecamatan Kaliwates dan area Sumbersari. Sedangkan kecamatan dengan perkembangan wilayah terendah berada pada Kecamatan Arjasa, Kecamatan Jelbuk, Kecamatan Jombang, Kecamatan Mayang, Kecamatan Pakusari, serta Kecamatan Sukorambi.
Kata kunci: Perkembangan Wilayah, Visible and Infrared Imaging Radiometer Suite (VIIRS), Pusat Kegiatan
Politik Hukum Dalam Program Legislasi Di Indonesia
Authors: Arfandy Muh Farhan , Maharani A Rafika 
Published: February 2025

Penyusunan undang-undang yang demokratis harus menggambarkan peran hukum sebagai alat untuk memfasilitasi dinamika masyarakat. Dengan cara ini, peran hukum dalam negara yang sedang mengalami perubahan dapat mencakup semua kompleksitas masyarakat seperti Indonesia. Perkembangan teknologi dan industri menuntut kehadiran suatu kerangka hukum yang mampu mencapai tujuan yang diinginkan oleh masyarakat. Dalam artikel ini, akan dibahas tentang politik hukum dalam pembentukan undang-undang di Indonesia yang berkaitan dengan Konstitusi, sehingga dampaknya sesuai dengan yang diinginkan. Tujuan dari artikel ini antara lain, untuk mengetahui bagaimana aspek yang mempengaruhi legislasi di Indonesia, dan untuk mengetahui bagaimana Politik Hukum Legislasi di Indonesia. Adapun metode penelitian yang akan digunakan menggunakan metode penelitian normatif dengan pendekatan konsep dan pendekatan perundang-undangan. Untuk menghasilkan kualitas yang berbeda dengan kualitas legislasi saat ini membutuhkan proses dalam menghasikan produk tersebut, yaitu undang-undang, tanpa perubahan dalam mekanisme tersebut maka tidak bisa lagi kita berharap terjadi perubahan kualitas dengan mesin proses yang sama. Kekuasaan politik yang dijalankan oleh pemerintah bersama lembaga-lembaga kenegaraan lainnya, harus sesuai dengan konstitusi yang telah disepakati bersama demi tegaknya negara hukum. Dalam hal ini semua komponen bangsa, baik organisasi politik, harus secara sadar melaksanakan kewajibannya sesuai dengan aturan hukum.
De novo Genome Sequence of Roseibium alexandrii MAR44 Strain, a Marine Bacterium with Capacity to Synthesize PHA Bioplastics and a Photosynthesis Gene Cluster
Authors: García-Sánchez Susana , Soler Diego Saliente , Marín Anna , Cabedo Luis 
Published: February 2025

Abstract

We report here the genome sequence of Roseibium alexandrii strain MAR44, an alpha-proteobacterium isolated from an experimental device to monitor bioplastics colonization in the Mediterranean Sea. The genome assembly comprises a total of 5.25 Mb with a GC content of 56.33% and 5,019 predicted genes. Genome annotation reveals that MAR44 strain contains several pha genes involved in the polymerisation and depolymerisation of polyhydroxyalkanoates; phaA, phaB and phaC encode for the enzymes responsible of the last steps of the biosynthetic pathway, whereas phaZ encodes for a PHA-depolymerase. We also identified the phaR regulator and four phaP genes encoding for phasin proteins with a role in folding and accumulation of PHA in subcellular granules. In addition, we identified a photosynthesis gene cluster including the bch genes for the bacteriochlorophyll a synthesis and the puf operon encoding photosynthetic reaction centre and light-harvesting genes. In another manuscript we describe the efficient production of PHA by this strain under different conditions of carbon source supplementation and photosynthetic light.
Laser-Based Powder Bed Fusion Additive Manufacturing of Thinner Walls Through Re-melting
Authors: Mezghani Adnen , Nassar Abdalla R. , Simpson Timothy W. 
Published: February 2025

Abstract

In laser-based powder bed fusion (PBF-LB) additive manufacturing (AM), implementation of thin-walled structures (TWS) presents many advantages such as light weighting and increasing heat transfer efficiency in heat exchangers. However, PBF-LB AM of small features approaching the size of the melt pool, such as TWS, is associated with large geometric variability and increased defects. This is a consequence of using a global “contouring and filling” toolpath strategy which applies laser toolpaths irrespective of the feature size. Alternatively, it is hypothesized that a tailored laser toolpath strategy that incorporates adjusted laser scan paths allows for better control of the weld tracks to achieve thinner walls and reduce defects and build errors. To validate this hypothesis, we explore an alternative laser toolpath strategy specific to fabricating TWS via PBF-LB AM. We construct an implicit model of wall thickness as a function of laser parameters and wall inclination angle. Additionally, we quantify the effects of laser scan strategy, laser power, laser scanning speed, and inclination angle on through-porosity. Finally, we propose a generalizable method for finding the thinnest porosity-free wall achievable by using a non-dimensional enthalpy of welding approach.
Preclinical immunoPET imaging of thyroid-stimulating hormone receptor expression in thyroid cancer using [64Cu]Cu-NOTA-TSHR-Ab
Authors: Fu Wenhui , Parent Ephraim E. , Gleba Justyna J. , Knight Joshua A. , III John A. Copland , Cai Hancheng 
Published: February 2025

Abstract

Purpose The thyroid-stimulating hormone receptor (TSHR) is a cell-surface receptor predominantly expressed on benign and malignant thyroid cells, making it a viable target for developing radiotheranostics for metastatic thyroid cancer imaging and therapy. This study reports the radiosynthesis and preclinical evaluation of a 64Cu-labelled human antibody for positron emission tomography (PET) imaging of TSHR expression in thyroid cancer mouse models.
Methods Human anti-TSHR recombinant antibody K1-70™ (TSHR-Ab) was conjugated with a bifunctional chelator, 2-S-(4-isothiocyanatobenzyl)-1,4,7-triazacyclononane-1,4,7-triacetic acid (p-SCN-Bn-NOTA), and then labelled with [64Cu]Cu2+, yielding radiotracer [64Cu]Cu-NOTA-TSHR-Ab. The specificity and binding affinity of the radiotracer to TSHR-positive (THJ529TTSHR(+)) or wild-type (THJ529TWT) cells were assessed in vitro. A series of immnuoPET imaging with [64Cu]Cu-NOTA-TSHR-Ab were conducted in mice bearing dual-flank tumors (THJ529TWT on the left and THJ529TTSHR(+) on the right) at multiple time points (1, 2, 4, 18, 24, and 48 h) post-injection (p.i.). Radiotracer co-injection studies with varying doses of unlabelled (cold) TSHR-Ab (100, 50, 25, 0 µg) were studied to assess its effect on radiotracer uptake in tumors and off-target organs. Biodistribution and immunohistochemistry (IHC) were performed to verify the immnuoPET imaging results.
Results [64Cu]Cu-NOTA-TSHR-Ab was synthesised with a radiochemical yield of 46.89 ± 3.74%, radiochemical purity of 98.77 ± 0.89%, and specific activity >1.42 GBq/mg (n = 5). In vitro cell studies demonstrated [64Cu]Cu-NOTA-TSHR-Ab had high specificity and nanomolar affinity for THJ529TTSHR(+) cells, with a dissociation constant (Kd) of 4.74 nM and an inhibition constant (Ki) of 0.92 nM. The immnuoPET imaging studies showed that the radiotracer could reach tumor quickly and showed high uptake in TSHR-positive thyroid tumors (SUVmax: 3.63 ± 0.42, 3.82 ± 0.44, and 4.09 ± 0.56 at 18, 24, and 48 h p.i., respectively). Co-injection with cold TSHR-Ab at doses ranging from 25 to 100 µg effectively reduced background signals, especially in spleen, liver, and bone. Notably, a dose of 25 µg cold TSHR-Ab reduced off-target signals without affecting tumor uptake. The biodistribution and IHC analyses further supported PET imaging findings.
Conclusion TSHR-targeted radiotracer [64Cu]Cu-NOTA-TSHR-Ab was synthesized with high radiochemical purity. Our preclinical evaluation results demonstrate it is a promising radiotracer for PET imaging of TSHR-positive thyroid cancer, which may guide and monitor TSHR-targeted therapies. High radiotracer uptake in tumor, prolonged retention time, and favourable pharmacokinetics with the support of cold antibody co-injection, pave the way for the development of paired radiotherapeutics to treat TSHR-positive thyroid cancers.
The Role Of S100B Calcium-Binding Protein And Some Biochemical Markers In Early Detection And Progression Of Breast Cancer
Authors: Attawi Jamal . A. ALjabbar , Hailan Sarah Y. , Mohaibes Mohammed 
Published: February 2025

Abstract

Breast carcinoma is the most typical malignancy among women. Therefore, early detection with breast cancer is helpful for the treatment, although other markers are required to increase accuracy. The study's objectives were to determine the effects of these markers on patients with breast cancer and the role that immunoglobulins (IgG, IgM) and S100B levels play in early diagnosis and the ability to distinguish between benign and malignant breast cancers. There were a significant increase in levels of IgG, IgM, calcium, ALP and S100B in breast cancer women in comparison with pathological and healthy controls. While there were no significantly differ in levels of IgG, IgM, and S100B, when compared pathological controls to healthy controls. These values of IgG, IgM, and S100B can be used in differentiation between benign tumors from malignant breast tumors .While a significant decrease in 1,25(OH)2 Vitamin D, phosphorus patients with breast cancer in comparison with healthy controls .These values make these parameters highly significant for early diagnosis and progression of breast cancer.
Proprietary Costs of Financial Reporting, Country-Level Attributes, and Financial Statement Comparability
Authors: Gil Jangho , Gotti Giorgio , Sobngwi Christian K. 
Published: February 2025

ABSTRACT
Previous studies indicate the existence of a negative relation between proprietary costs of financial reporting and financial statement comparability in the United States. However, this relation may vary depending on the strength of the financial reporting environment. Using four country-level latent factors suggested in Isidro, Nanda, and Wysocki (2020), this study investigates the impact of country-level attributes on the relation between proprietary costs of financial reporting and financial statement comparability. We find that the negative relation is stronger in countries with relatively poorer financial reporting environments. Furthermore, we find that strong protection of investor rights and better-developed capital markets are most effective in improving financial reporting quality, as evidenced by higher accounting comparability. This study provides guidance for standard setters in countries with poor financial reporting environments. Standard setters should emphasize strong protection of investor rights and further promote the development of capital markets to enhance firms’ financial reporting quality.
Data Availability: Data are available from the public sources cited in the text.
JEL Classifications: M41; G30; M16.
UNA LECTURA DERRIDIANA DE ALGO QUEMA (2018): EL MAL DE UN ARCHIVO FAMILIAR
Authors: Laguna-Tapia Andrés , Villena Belén 
Published: February 2025

Este artículo propone una lectura derridiana del documental Algo Quema (2018) de Mauricio Alfredo Ovando, centrándose en la exploración que realiza la película de los archivos familiares y la compleja relación entre la memoria, la historia y la identidad. Al examinar la confrontación del cineasta con el controvertido pasado de su abuelo, Alfredo Ovando Candia, la película expone las tensiones entre las historias personales y las públicas. A través de una perspectiva deconstructiva, el artículo reflexiona sobre cómo la película emplea técnicas cinematográficas para interrogar la naturaleza del archivo. Algo Quema revela el archivo como un espacio dinámico y disputado donde los recuerdos se construyen y reconstruyen continuamente. La exploración de la película sobre el mal de archivo destaca el potencial destructivo y creativo de la memoria, así como las formas en que individuos y familias lidian con historias difíciles. Aplicando el concepto derridiano de phármakon, el artículo argumenta que la película funciona como una sustancia que opera de acuerdo a la dosis y a quien es inoculada. La capacidad de la película para abrir nuevas posibilidades de comprensión del pasado se ve atenuada por el doloroso proceso de confrontar eventos traumáticos. Propone que Algo Quema ofrece una reflexión sobre el papel de la memoria en la configuración de nuestras identidades, sobre las formas en las que el pasado continúa acechando el presente y al porvenir.
Subcutaneous tiletamine-zolazepam produces moderate sedation in red-eared sliders (Trachemys scripta elegans) regardless of injection site
Authors: Farris Katharine Hausmann , Collins Elijah J. , Mans Christoph , Doss Grayson A. 
Published: February 2025

Abstract

OBJECTIVE
To evaluate the efficacy of tiletamine-zolazepam (TZ) for sedation of red-eared sliders and to assess the effect of injection site location on sedation parameters.

METHODS
Over a 1-month trial period, healthy turtles obtained from a rescue were administered TZ (10 mg/kg, SC) in the forelimb (FL) or hind limb (HL) in a randomized, blinded crossover design in a laboratory setting. Heart rate; respiratory rate; neck, forelimb, and hind limb muscle tone; pelvic limb withdrawal reflex; jaw tone; cloacal tone; and feasibility of positioning for jugular venipuncture were evaluated. Flumazenil at 0.05 mg/kg was administered SC 45 minutes after TZ injection for recovery. Time to first effects, total sedation score, and time to recovery were recorded.

RESULTS
There was no significant difference in mean time to initial sedative effects between FL (11 ± 4 minutes) and HL (14 ± 6 minutes) treatments in the study population (n = 8 turtles). Six of 8 turtles (75%) and 5 of 8 turtles (63%) in the FL and HL treatments, respectively, developed decreased muscle tone. Simulated jugular venipuncture was successful in 7 of 8 turtles (88%) in both treatments, although additional restraint was required in 3 of 8 turtles (43%) in the HL group. There was no significant difference in total sedation score at any time point between treatments, and median heart rate across the sedative period was similar between treatment groups. Mean time to recovery was similar between treatments (FL, 135 ± 55 minutes; HL, 165 ± 45 minutes).

CONCLUSIONS
Tiletamine-zolazepam (10 mg/kg) produced moderate sedation of red-eared sliders. The location of SC TZ injection administration did not significantly affect sedation parameters in this species.

CLINICAL RELEVANCE
Subcutaneous TZ can be used for sedation of red-eared sliders in clinical practice to facilitate examination and blood collection in this species.
Evaluation of monitoring critical ill children with traumatic brain injury
Authors: Misirlioglu Merve , Yildizdas Dincer , Ekinci Faruk , Horoz Ozden Ozgur , Mert Gulen Gul 
Published: February 2025

Abstract

Introduction
In traumatic brain injury (TBI), direct information can be obtained about cerebral blood flow, brain tissue oxygenation and cerebral perfusion pressure values. More importantly, an idea about the changes in these measurements can be obtained with multidimensional monitoring and widely used monitoring methods.

Aim of the study
We aimed to evaluate the monitoring of critically ill children who were followed up in our pediatric intensive care unit (PICU) due to TBI.

Material and Method
Twenty-eight patients with head trauma who were followed up in our tertiary PICU between 2018 and 2020 were included in the study. Cerebral tissue oxygenation, optic nerve sheath diameter (ONSD), Glasgow coma score (GCS) and Glasgow Outcome Score (GOSE) values were obtained from retrospective file records and examined.

Results
Male gender was 71.4% (n=20). When we classified TBI according to GCS, 50% (n=14) had moderate TBI and 50% had severe TBI. On the first day in the poor prognosis group, ONSD and nICP were found to be higher than in the good prognosis group (for ONSD, p=0.01; and for nICP, p=0.004). On the second day of hospitalization, the ONSD and nICP were significantly higher in the poor prognosis group than in the good prognosis group (for ONSD p=0.002; and for nICP p= 0.001). Cerebral tissue oxygenation values measured on the first and second days decreased significantly on the second day in both the good and poor prognosis groups (p=0.03, 0.006). In the good prognosis group, a statistically significant decrease was found in ONSD and nICP measurements taken on the 2nd day compared to the measurements taken at the time of hospitalization (for ONSD p=0.004; for nICP p<0.001).

Conclusion
The aim of multidimensional follow-up in traumatic brain injury is to protect the brain from both primary and secondary damage; for this reason, it should be followed closely with multimonitoring methods that are possibly multidisciplinary.