bluuebunny/crossref_metadata_2025_split huggingface dataset:
Navigating the complexities of encephalocraniocutaneous lipomatosis: a case series and review
Authors: Pavanello Marco , Piro Liliana , Roggero Arianna , Rossi Andrea , Cataldi Matteo , Piatelli Gianluca 
Published: January 2024

Abstract
Introduction
Encephalocraniocutaneous lipomatosis (ECCL) is a rare congenital syndrome with complex skin, eye, and central nervous system (CNS) symptoms. Diagnosis and treatment are challenging due to its rarity and diverse manifestations. It often involves issues like porencephalic cysts, cortical atrophy, and low-grade gliomas in the CNS, resulting in developmental delays. The spinal cord is frequently affected, leading to problems like medullary compression and radiculopathy, causing back pain and sensory/motor deficits. Surgical interventions are reserved for symptomatic cases to address hydrocephalus or alleviate spinal lipomas. This article reviews a case series to assess surgical risks and neurological outcomes.

Case series
We present a case series ECCL, focusing on the diffuse lipomatosis of the spinal cord and the intricate surgical procedures involved. A multi-stage surgical approach was adopted, with continuous neuromonitoring employed to safeguard motor pathways. We discuss clinical characteristics, imaging studies, and indications for neurosurgical interventions.

Discussion
ECCL is a complex syndrome. Diagnosis is challenging and includes clinical evaluation, neuroimaging, and genetic testing. Treatment targets specific symptoms, often requiring surgery for issues like lipomas or cerebral cysts. Surgery involves laminectomies, spinal fusion, and motor pathway monitoring. Thorough follow-up is crucial due to potential CNS complications like low-grade gliomas. Hydrocephalus occurs in some cases, with endoscopic third ventriculostomy (ETV) preferred over ventriculoperitoneal shunt placement.

Conclusion
Neurosurgery for ECCL is for symptomatic cases. ETV is preferred for hydrocephalus, while the treatment for lipoma is based on the presence of symptoms; the follow-up should assess growth and prevent deformities.
Prevalence, clinical characteristics, and risk factors of intracerebral haemorrhage in CADASIL: a case series and systematic review
Authors: Sukhonpanich Nontapat , Markus Hugh S. 
Published: January 2024

Abstract
Background
Cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy (CADASIL) is the most common monogenic form of stroke and is characterised by early onset stroke and dementia. Most strokes are lacunar ischaemic strokes, but intracerebral haemorrhage (ICH) has also been reported, although there are limited published data on its frequency and characteristics.

Methods
A retrospective review of a prospectively recruited CADASIL register from the British National Referral clinic was performed to identify acute ICH cases and their characteristics. In addition, a systematic review of ICH in CADASIL was performed. MEDLINE (Pubmed), Embase, and Web of Science were searched for articles published from inception until 31/05/2023.

Results
Ten cases of ICH were identified from the National clinic register of 516 symptomatic patients, giving an estimated point prevalence of 1.9%. An additional 119 cases were identified from the systematic review, comprising 129 cases and 142 ICH events in total. Including all identified cases, the mean age at onset of ICH was 56.6 ± 15.7 (SD) years, and 74 (57.4%) were male. ICH was the first manifestation of the disease in 32 patients (38.1%), and ICH recurrence occurred in 16 (12.4%). Most ICHs were subcortical, with the thalamus, 58 (40.8%), and basal ganglia, 34 (23.9%), being the commonest sites. Anticoagulation, but not antiplatelet agents, was associated with an increased risk of ICH (20.0% vs. 1.9%, p = 0.006).

Conclusions
ICH is a relatively rare manifestation of CADASIL, occurring in about 2% of symptomatic cases. Most of the haemorrhages occurred in the subcortical regions.
Flare levels after intravitreal injection of brolucizumab for diabetic macular edema
Authors: Ichihashi Yushi , Takamura Yoshihiro , Hirano Takao , Shimura Masahiko , Yoneda Keisuke , Konno Keiichiro , Yamada Yutaka , Morioka Masakazu , Gozawa Makoto , Matsumura Takehiro , Inatani Masaru 
Published: January 2024

Abstract
Purpose
This study aimed to evaluate anterior flare intensity (AFI) after intravitreal injection of brolucizumab (IVBr) in patients with diabetic macular edema (DME), and to identify the factors associated with the change of AFI after IVBr.

Methods
This prospective multicenter study was conducted at five sites in Japan for patients with DME who underwent a single IVBr. AFI and central retinal thickness (CRT) were measured using a laser flare meter and spectral-domain optical coherence tomography, respectively, at weeks 0 and 6.

Results
Sixty-five patients (phakia, 37 eyes; pseudophakia, 28 eyes) were enrolled. Six weeks after IVBr, CRT and best-corrected visual acuity significantly improved (p < 0.0001). AFI (p = 0.0003) and age (p = 0.0054) were significantly higher in patients with pseudophakic eyes than those with phakic eyes. The AFI of the phakic eyes decreased after IVBr (p = 0.043). As the AFI before injection is higher (p = 0.0363) and the age is lower (p = 0.0016), the AFI decreases after IVBr. There was a significant positive correlation between the rates of change in CRT and AFI (p = 0.024).

Conclusion
After IVBr, AFI decreases in phakic eyes but not in pseudophakic eyes. The age, AFI and CRT before injection and changes of CRT are involved in the change in AFI after IVBr.
Gall-forming nematode, Anguina woodi (Nematoda: Anguinidae) and Chalcid wasp (Hymenoptera: Eurytomidae), on dune grass from the Western Cape, South Africa
Authors: Chauke T. R. , Malatji D. P. , Subbotin S. A. , Maseko Z. , Mamabolo M. M. , Swart A. 
Published: January 2024

AbstractIn 2021/2022, galls formed by a nematode, Anguina woodi, were found on the stems, leaves and leaf sheaths of dune grass, Ehrharta villosa var. villosa on Milnerton Beach, Blouberg Beach and Langebaan, Western Cape Province, South Africa. These galls were spongy in texture, deep purple to blackish in colour and non-pedunculate. They were found in clusters, but also as single entities. Larger, harder galls varying from beige to dark brown in colour, apparently caused by insects, were also found on the stems of dune grass at Blouberg Beach and Langebaan Nature Reserve. Some nematode galls were found immediately next to or on top of the insect galls. Those found on top of insect galls seemed to be harder and drier than those found on stems not infected by insect galls. The co-infection of insects and anguinid nematodes has not been reported from the current study areas and was thus included in the present study. Both molecular and morphological studies were conducted on the nematodes and wasps leading to the identification of a host specific, gall-forming nematode from all three localities. The wasps were identified morphologically and molecularly to the family Eurytomidae (Hymenoptera). No insect galls were found on dune grass from Milnerton Beach. The paper includes speculations on a probable association between nematodes and insects.
Widespread fracture movements during a volcano-tectonic unrest: the Reykjanes Peninsula, Iceland, from 2019–2021 TerraSAR-X interferometry
Authors: Ducrocq Cécile , Árnadóttir Thóra , Einarsson Páll , Jónsson Sigurjón , Drouin Vincent , Geirsson Halldór , Hjartardóttir Ásta Rut 
Published: January 2024

AbstractTectonic controls on dyke emplacements, eruption dynamics and locations have been observed in multiple volcanic areas worldwide. Mapping of active structures is therefore key for assessing potential tectonic and volcanic hazards in active regions. We used wrapped interferograms from the TerraSAR-X satellite to map active fracture movements over a 2-year period of a volcano-tectonic unrest at the onshore Reykjanes Peninsula plate boundary in SW Iceland. As of 1 December 2023, the unrest has included at least six inflation events and five dyke injections resulting in three eruptions of the Fagradalsfjall volcanic segment. In addition to the deformation associated with the 2019–2021 inflation events and intrusions, the interferograms reveal fracture movements over a wide area surrounding the active plate boundary segment. This first-order mapping of active fractures complements previously mapped structures, as InSAR allows for the detection of subtle ground movements, even in areas where young lava flows cover older structures. Our fracture data therefore fill in some of the apparent voids in previous fracture and fault maps of SW Iceland. Furthermore, our investigation reveals aseismic movement on previously unknown fractures directly beneath the town of Grindavík, as well as a N45$$^\circ $$

∘

E striking fracture co-located with the longest lasting volcanic vent of the subsequent 2021 eruption. The mapping method we present in this study is relevant for active volcano-tectonic regions where InSAR can be applied to detect small-scale fracture movements to advance understanding of ongoing unrest and volcano-tectonic hazards.
The effectiveness of physiotherapy interventions on fecal incontinence and quality of life following colorectal surgery: a systematic review and meta-analysis of randomized controlled trials
Authors: Pun Ming Yan , Leung Pak Ho , Chan Tsz Ching , Pang Chunn , Chan Kin Hei , Kannan Priya 
Published: January 2024

Abstract
Purpose
To investigate the effectiveness of physiotherapy interventions compared to control conditions on fecal incontinence (FI) and quality of life (QoL) following colorectal surgery.

Methods
Electronic searches in English-language (Scopus, Web of Science, Embase, AMED, CENTRAL, CINAHL, MEDLINE, Ovid, and PEDro) and Chinese-language (CNKI, Wanfang Data) databases were conducted. Trials comparing physiotherapy interventions against control conditions and assessing FI and QoL outcomes were included in the review.

Results
Ten trials were included. Meta-analysis revealed statistically significant improvements in lifestyle (0.54; 95% CI 0.03, 1.05; p = 0.04), coping behavior (MD 1.136; 95% CI 0.24, 2.04; p = 0.01), and embarrassment (0.417; 95% CI 0.14, 0.70; p = 0.00) components of QoL among individuals receiving pelvic floor muscle training (PFMT) compared with those receiving usual care (UC). Meta-analysis showed biofeedback to be significantly more effective than UC in enhancing anal resting pressure (ARP; 9.551; 95% CI 2.60, 16.51; p = 0.007), maximum squeeze pressure (MSP; 25.29; 95% CI 4.08, 48.50; p = 0.02), and rectal resting pressure (RRP; 0.51; 95% CI 0.10, 0.9; p = 0.02). Meta-analysis also found PFMT combined with biofeedback to be significantly more effective than PFMT alone for ARP (3.00; 95% CI 0.40, 5.60; p = 0.02), MSP (9.35, 95% CI 0.17, 18.53; p = 0.05), and RRP (1.54; 95% CI 0.60, 2.47; p = 0.00).

Conclusions
PFMT combined with biofeedback was more effective than PFMT alone, but both interventions delivered alone were superior to UC. Future studies remain necessary to optimize and standardize the PFMT parameters for improving QoL among individuals who experience FI following CRC surgery.

Review registration
This systematic review is registered in the PROSPERO registry (Ref: CRD42022337084).
Design of an efficient neural network model for detection and classification of phase loss faults for three-phase induction motor
Authors: Dawood Ahmed , Hasaneen B. M. , Abdel-Aziz A. M. 
Published: January 2024

AbstractIn industrial applications, three-phase induction motors (IMs) are widely used, and they are subjected to many types of faults. One such fault is the loss of a motor phase caused by a blown fuse, a broken wire, mechanical damage, etc. When this fault occurs during motor operation, it continues to rotate but experiences rapid heating, which can ultimately lead to motor failure. Therefore, various protection devices are available to protect the motor against this fault, but most traditional protection devices do not offer a comprehensive classification of such a fault. So, in this paper, an efficient neural network model is presented for detecting and classifying 12 types of phase loss faults for a three-phase induction motor (IM) based on factors such as the unhealthy phase, fault location, and motor action modes (standstill, transient, and steady-state modes). Thus, the main goal of this work is to determine the motor mode during the fault, the defective phase, and its location to help the maintenance team repair the fault quickly. The system is simulated and tested using the “MATLAB/Simulink” software, employing a feed-forward neural network. The simulation results demonstrate that the proposed network achieves correct detection and classification of phase loss faults within a short time frame from the occurrence of the fault. Therefore, the proposed network model proves to be a simple and reliable solution for integration into the protection system of a three-phase IM, enabling the detection and classification of various phase loss faults.
Evolving trends in the surgical, anaesthetic, and intensive care management of acute spinal cord injuries in the UK
Authors: Asif Hasan , Tsan Samuel Ern Hung , Zoumprouli Argyro , Papadopoulos Marios C. , Saadoun Samira 
Published: January 2024

Abstract
Purpose
We surveyed the treatment of acute spinal cord injuries in the UK and compared current practices with 10 years ago.

Methods
A questionnaire survey was conducted amongst neurosurgeons, neuroanaesthetists, and neurointensivists that manage patients with acute spinal cord injuries. The survey gave two scenarios (complete and incomplete cervical spinal cord injuries). We obtained opinions on the speed of transfer, timing and aim of surgery, choice of anaesthetic, intraoperative monitoring, targets for physiological parameters, and drug treatments.

Results
We received responses from 78.6% of UK units that manage acute spinal cord injuries (33 neurosurgeons, 56 neuroanaesthetists/neurointensivists). Most neurosurgeons operate within 12 h for incomplete (82%) and complete (64%) injuries. There is a significant shift from 10 years ago, when only 61% (incomplete) and 30% (complete) of neurosurgeons operated within 12 h. The preferred anaesthetic technique in 2022 is total intravenous anaesthesia (TIVA), used by 69% of neuroanaesthetists. Significantly more intraoperative monitoring is now used at least sometimes, including bispectral index (91%), non-invasive cardiac output (62%), and neurophysiology (73–77%). Methylprednisolone is no longer used by surgeons. Achieving at least 80 mmHg mean arterial blood pressure is recommended by 70% neurosurgeons, 62% neuroanaesthetists, and 75% neurointensivists.

Conclusions
Between 2012 and 2022, there was a paradigm shift in managing acute spinal cord injuries in the UK with earlier surgery and more intraoperative monitoring. Variability in practice persists due to lack of high-quality evidence and consensus guidelines.
Salivary and serum asprosin hormone levels in the 2018 EFP/AAP classification of periodontitis stages and body mass index status: a case-control study
Authors: Gül Sema Nur Sevinç , Eminoğlu Didem Özkal , Laloğlu Esra , Aydın Tuğba , Dilsiz Alparslan 
Published: January 2024

Abstract
Objectives
A newly discovered adipokine known asprosin in serum and saliva in patients with periodontitis has not been explored. The aim of this study was to determine the relationship between serum and saliva asprosin levels and periodontitis by grouping it according to body mass index (BMI).

Materials and methods
The study was conducted on 65 systemically healthy patients (35 patients with periodontitis (periodontitis group), 30 periodontally healthy patients (control group)). In each patient, age, BMI, and clinical periodontal parameters (plaque index (PI), gingival index (GI), probing depth (PD), and clinical attachment level (CAL)) were evaluated. Statistical analyses were conducted utilizing the Student t-test, ANOVA, and Pearson correlation analysis. For the significance level of the tests, p<0.05 were accepted.

Results
The serum and saliva were collected to assess asprosin levels. Both the serum and saliva asprosin levels were statistically significantly higher in the periodontitis group than in the control group (p<0.001). Saliva and serum asprosin levels were directly proportional to the severity of the periodontal disease (p<0.05). Asprosin levels were higher in patients with a higher BMI (p<0.05).

Conclusion
Asprosin levels were increased in periodontitis, and even a high BMI status apparently affected the levels of this hormone. It is thought that asprosin may be a useful biomarker in evaluating the relationship between periodontal status and BMI.

Clinical relevance

Asprosin may be a useful parameter as a biomarker of periodontal disease progression. However, BMI status should be considered when evaluating asprosin levels in patients with periodontitis.
A bibliometric and Altmetric analysis of the 100 top most cited articles on dentin adhesives
Authors: Karabay Ferda , Demirci Mustafa , Tuncer Safa , Tekçe Neslihan , Berkman Meriç 
Published: January 2024

Abstract
Objective
This study aimed to identify the 100 top-cited articles on dentin adhesives utilizing comprehensive bibliometric and altmetric analyses.

Materials and methods
The Institute of Scientific Information Web of Knowledge database was used to compile the top-cited articles published from 1945 through February 12, 2023. Citation counts were manually retrieved for each article from Scopus, Google Scholar, Dimensions, and Altmetric. The articles were analyzed in terms of their number of citations, year, journal name, author (name, institution, and country), and type and specific field of study. We used descriptive statistics to summarize the results.

Results
The analysis revealed that the top 100 cited articles originated from 18 English-language journals and collectively accumulated a remarkable 34526 citations. The article with the highest number of citations garnered 1288 references. Among authors, Van Meerbeek B. stood out with nine articles and 4650 citations, followed by Pashley D.H. with six articles and 2769 citations. Japan was the leading contributor by country, while the Catholic University of Leuven led in terms of institutions with 20 articles.

Conclusion
According to this study, basic research and review articles garnered the most citations, respectively. The citation analysis revealed different trends for researchers, the first being that researchers have focused on basic fields such as the ultramorphology of dentin and adhesive interfaces, followed by bond strength to dentin. Two studies on clinical experiences suggested that studies with high-level evidence, such as systematic reviews, meta-analyses, or randomized controlled clinical trials, are required.

Clinical relevance
It is identified that more studies with high-level evidence-based research are needed in the field of dental adhesives.
Developing a framework for heterotopias as discursive playgrounds: a comparative analysis of non-immersive and immersive technologies
Authors: Korkut Elif Hilal , Surer Elif 
Published: January 2024

AbstractThe discursive space represents the reordering of knowledge gained through accumulation. In the digital age, multimedia has become the language of information, and the space for archival practices is provided by non-immersive technologies, resulting in the disappearance of several layers from discursive activities. Heterotopias are unique, multilayered epistemic contexts that connect other systems through the exchange of information. This paper describes a process to create a framework for Virtual Reality, Mixed Reality, and personal computer environments based on heterotopias to provide absent layers. This study provides virtual museum space as an informational terrain that contains a “world within worlds” and presents place production as a layer of heterotopia and the subject of discourse. Automation for the individual multimedia content is provided via various sorting and grouping algorithms, and procedural content generation algorithms such as Binary Space Partitioning, Cellular Automata, Growth Algorithm, and Procedural Room Generation. Versions of the framework were comparatively evaluated through a user study involving 30 participants, considering factors such as usability, technology acceptance, and presence. The results of the study show that the framework can serve diverse contexts to construct multilayered digital habitats and is flexible for integration into professional and daily life practices.
A scope of presence-related feelings in AR studies
Authors: Marto Anabela , Gonçalves Alexandrino 
Published: January 2024

AbstractThe idiosyncrasies of augmented reality bring us advantages, as shown in literature, and a great assortment of options. On the other hand, due to its relationship with the real surroundings, it may be a challenge to deal with when evaluating these systems, especially if the intention is to understand feelings of presence-like: There are a lot of variables in the equation. This study aims to analyse a state of the art of AR evaluations that conducted presence-related feelings and discusses limitations and remarks for further research. The current research is able to state that questionnaires are the most used tool to ascertain presence-like feelings, and that mobile devices have been the preferred device to implement AR applications. The studies are fairly divided between 1) analysing a single scenario to ascertain the variable at study, and 2) creating two or more scenarios to make a comparison. When comparing two or more scenarios, a between-subjects design is preferred among researchers. Additionally, it has been identified as of paramount importance the need to study and objectively measuring the ratio between the virtual content and the real scenario in the experience, as well as to deeply research the interaction between the real scenario and the virtual elements. The importance of the types of interaction in AR applications is also highlighted.