bluuebunny/crossref_metadata_2025_split huggingface dataset:
Zoonotic risks of pathogens from dairy cattle and their milk-borne transmission
Authors: Holzhauer Menno , Wennink Gerrit Jan 
Published: January 2024

AbstractDairy products are major sources of high-quality protein and bioavailable nutrients and dairy production contributes to local, regional and national-level economies. Consumption of raw milk and raw milk products does, however, carry a zoonotic risk, as does direct contact with cattle by farm husbandry staff and other employees. This review will mainly focus on the latter, and deal with it from the standpoint of a well-developed dairy industry, using the example of the Netherlands. With regard to dairy cattle, the main bacterial pathogens are Salmonella spp., Listeria monocytogenes and Leptospira hardjo as well as Brucella abortus and Chlamydia abortus. The main viral pathogens associated with dairy are Rift Valley fever virus, rabies virus, cowpox virus and vaccinia virus. The main parasitological infections are Echinococcus granulosis, Cryptosporidium parvum and Giardia duodenalis, however, the last mentioned have mainly swimming pools as sources of human infection. Finally ectoparasites such as lice and mites and Trichophyton verrucosum may affect employees. Some pathogens may cause health problems due to contamination. Bacterial pathogens of importance that may contaminate milk are Campylolobacter jejuni, Escherichia coli, Mycobacterium avium subsp. paratuberculosis, Leptospira hardjo and Salmonella typhimurium. Excretion of zoonotic viruses in milk is negligible in the Netherlands, and the endoparasite, Toxocara vitulorum is mainly found in suckling and fattening calves, whilst the risk in dairy cattle is limited. Excretion of transmissible spongiform encephalopathies (TSEs) or mycoses in milk are not expected and are, therefore, not of importance here.Being aware of the risks and working according to hygiene standards can substantially limit zoonotic risks for employees. Additionally, diseased employees are advised to limit their contact with cattle and to indicate that they work with cattle when consulting a physician. To prevent zoonotic risks through excretion of pathogens in milk, standard hygiene measures are necessary. Further, using only pasteurised milk for consumption and/or processing of milk can considerably limit the risks. If these measures are not possible, well-constructed monitoring can be followed. Monitoring programmes already exist for pathogens such as for Salmonella spp., Leptospira hardjo and Mycobacterium avium subsp. paratuberculosis. For others, like Campylobacter jejuni and E. coli, programmes are not available yet as far as we know.
Global sociology and its discontents
Authors: Roudometof Victor 
Published: January 2024

AbstractSociology emerged in the course of Western modernization; its major classical-era statements are preoccupied with modernity and its impact on national societies. After decolonization, ‘Third World’ modernization paved the way for the notion of globalization. The sociology of globalization is a current specialty within US and European sociological associations. The promise of global sociology has been on the agenda of the International Sociological Association since at least 1990. At a deeper level, global sociology requires un-thinking the role of core concepts such as modernity or religion or society vis-à-vis their Western origins. Global Studies and post-colonial sociology, two of the most widely known research fields claiming global intent, are examined with respect to whether they provide adequate conceptual resources for global sociology. While the research agendas of both offer promising insights, inquiry suggests that both suffer from important drawbacks. The sociological tradition is now facing an impasse; fragmentation may persist, but other possibilities also exist. No grand solution is perhaps possible. A truly global sociology may eventually emerge from the original interpretations that develop from non-Western historical paths.
Percutaneous pulmonary valve implantation in a patient with a single pulmonary artery and distal narrowing
Authors: Szeliga Judyta , Moszura Tomasz , Góreczny Sebastian 
Published: January 2024

AbstractPercutaneous pulmonary valve implantation is established as a safe and effective method of treating patients with disfunction of right ventricular outflow tract. Modifications of this method allow for an increasingly wider use of this less invasive treatment. We present a staged percutaneous pulmonary valve implantation into a single-branch pulmonary artery in a paediatric patient with tetralogy of Fallot after patch repair.
Predictors of anemia in mothers and children in Uttar Pradesh, India
Authors: Larson Leila M , Thomas Tinku , Kurpad Anura V , Martorell Reynaldo , Hoddinott John , Adebiyi Victoria , Swaminathan Sumathi , Neufeld Lynnette M 
Published: January 2024

Abstract

Objective:
Anemia affects more than half of Indian women and children, but the contribution of its causes remains unquantified. We examined interrelationships between hemoglobin and nutritional, environmental, infectious, and genetic determinants of anemia in non-pregnant mothers and children in Uttar Pradesh (UP).

Design:
We conducted a cross-sectional survey of households in 25 districts of UP between October and December 2016. We collected socio-demographic data, anthropometry, and venous blood in 1238 non-pregnant mothers and their children. We analyzed venous blood samples for malaria, hemoglobin, ferritin, retinol, folate, zinc, vitamin B12, C-reactive protein (CRP), α1-acid glycoprotein (AGP), and β-thalassemia. We used path analysis to examine pathways through which predictors of anemia were associated with hemoglobin concentration.

Setting:
Rural and urban households in 25 districts of UP.

Participants:
Mothers 18-49 years and children 6-59 months in UP.

Results:
A total of 36.4% of mothers and 56.0% of children were anemic, and 26.7% of women and 44.6% of children had iron deficiency anemia. Ferritin was the strongest predictor of hemoglobin [β (95% CI) = 1.03 (0.80, 1.27) g/dL in women and 0.90 (0.68, 1.12) g/dL in children]. In children only, red blood cell folate and AGP were negatively associated with hemoglobin and retinol was positively associated with hemoglobin.

Conclusions:
Over 70% of mothers and children with anemia had iron deficiency, needing urgent attention. However, several simultaneous predictors of hemoglobin exist, including nutrient deficiencies and inflammation. The potential of iron interventions to address anemia may be constrained unless coexisting determinants are jointly addressed.
ENSO and NAO Linkage to Strong Volcanism and Associated Post‐Volcanic High‐Latitude Winter Warming
Authors: Dogar Muhammad Mubashar , Fujiwara Masatomo , Zhao Ming , Ohba Masamichi , Kosaka Yu 
Published: January 2024

AbstractHigh‐latitude winter warming was observed following strong tropical volcanism, which has long been believed to be due to the volcanic‐induced positive North Atlantic Oscillation (NAO) phase. However, recent works argue that this warming is caused by El Niño–Southern Oscillation (ENSO) variability instead of volcanoes. Moreover, some studies further argue that El Niño and volcanoes work together to produce this post‐volcanic NAO winter warming. To better understand these arguments on post‐volcanic high‐latitude winter warming, we conducted ENSO‐preconditioned volcanic experiments. Our simulations strongly suggest that the post‐eruption Eurasian winter warming is caused by a post‐eruption positive NAO phase and not by coexisting ENSO‐preconditioned variability. Additionally, we find that the El Niño‐preconditioned volcanic eruption enhances the El Niño phase; however, the neutral and La Niña‐preconditioned eruptions do not lead to an ENSO–like response. These findings are helpful to better understand volcanic‐induced circulation impacts and have important implications for the interpretation of model results and post‐volcanic prediction.
Ensemble Bayesian Model Averaging Projections of Wind‐Speed Extremes for Wind Energy Applications Over China Under Climate Change
Authors: Zhao Xiaohu , Huang Guohe , Lu Chen , Li Yongping , Ren Jiayan 
Published: January 2024

AbstractWind energy has grown rapidly in recent years as a measure to control carbon emissions and mitigate climate change. Extreme wind can damage wind turbines, cause losses to wind power plants, limit economic benefits of wind energy facilities, and disrupt regional grid balance. Therefore, an accurate assessment of extreme wind speeds at wind turbine hub height and their spatiotemporal variation under climate change is critical for the planning of wind energy and for guaranteeing regional energy security. In this study, the 100‐m extreme wind speeds in China are estimated using an empirical downscaling and Bayesian model averaging ensemble method with the latest ERA5 reanalysis and 20 global climate models (GCMs) from the Coupled Model Intercomparison Project phase 6 (CMIP6). Two shared socioeconomic pathways (SSP), that is, SSP2‐4.5 and SSP5‐8.5, are considered to account for the uncertainty in anthropogenic emissions. According to the results, the highest extreme wind speeds are primarily found in Inner Mongolia, northeast China, western Tibet, and the eastern coastal region. Extreme wind speeds in central and southeastern China are projected to increase by approximately 2% in the middle (2031–2060) and the end (2071–2100) of the 21st century relative to the baseline period (1985–2014). Summer extreme wind speeds in northwestern Tibet are expected to increase by more than 9% at the end of the century. The findings of this study indicate that it is important to take the present and projected changes in local wind extremes into account when choosing locations for wind power plants and wind energy installations.
Characteristics and Mechanism of Interhemispheric Coupling in Austral Winter Revealed by Long‐Term Reanalysis Data for the Whole Middle Atmosphere
Authors: Koshin Dai , Sato Kaoru 
Published: January 2024

AbstractGlobal characteristics of dynamical fields for the interhemispheric coupling (IHC) initiated with a sudden stratospheric warming (SSW) in the southern hemisphere in the austral winter were examined using the global reanalysis for the whole neutral atmosphere from a data assimilation with satellite observations over 15 years of 2005–2019. Even in the austral winter, a strong cold equatorial stratosphere associated with the SSW, which is essential for the IHC, occurs about once every two years. The mechanism of the IHC in the austral winter is basically similar to that in the boreal winter. However, there are two significant differences in the IHC characteristics between the austral and boreal winters. One is that the SSW in the austral winter occurs mainly at midlatitudes, whereas the SSW in the boreal winter occurs mainly at high latitudes. As a result, a warm temperature anomaly simultaneously appears in the southern polar mesosphere in the austral winter, which is not observed for the boreal winter. The other is related to the seasonal variation of the quasi‐two‐day wave activity and induced forcing and gravity wave forcing in the summer mesosphere. For the IHC events occurring in July, when these wave activities and forcings are high, the response in the summer mesosphere is similar to that of the boreal winter. In contrast, for late August and September, when these wave forcings are weak, the response in the summer mesosphere is small. This result indicates that the IHC characteristics are largely influenced by the seasonal variation of these waves.
Contrasting Styles of Salt‐Tectonic Processes in the Ionian Zone (Greece and Albania): Integrating Surface Geology, Subsurface Data, and Experimental Models
Authors: Soto J. I. , Tranos M. D. , Bega Z. , Dooley T. P. , Hernández P. , Hudec M. R. , Konstantopoulos P. A. , Lula E. , Nikolaou K. , Pérez R. , Pita J. P. , Titos J. A. , Tzimeas C. , Herra Sánchez de Movellán A. 
Published: January 2024

AbstractThe Ionian Zone (IZ) is one of the key elements of the fold and thrust belt (FTB) of the Albanian and Hellenides orogen and contains large outcrops of Triassic evaporites. The IZ consists of various thrust sheets with a general westward vergence, stacking over the Apulian and Pre‐Apulian zones, and repeating a thick carbonate sequence of Upper Triassic to Eocene age. Thrusting becomes younger toward the west with a piggyback sequence, starting during the latest Oligocene Epoch in the Internal Ionian and ending in the Pliocene in the External Ionian. We have studied the IZ in southern Albania and northwestern Greece using field observations and borehole data and by fully interpreting a recently acquired 2D seismic data set. Our objectives are to establish the geometry and nature of the contacts associated with the major Triassic outcrops, to unravel precursor salt diapirs, and to assess their role during the Alpine contraction. Salt structures include gentle salt pillows, isolated salt plugs and diapirs, thrust welds, and salt walls. Combining these observations with experimental modeling results, we show how these structures control the geometry and kinematics of the Alpine thrusts or the location and kinematics of recent strike‐slip faults. Salt minibasins have also been identified, demonstrating salt mobility conditioned Mesozoic sedimentation in the Ionian Basin. The use of salt‐tectonics principles to evaluate the structural style and evolution of the IZ FTB also opens new directions for interpreting the subsurface structure and evolution of the region.
N-acetylcysteine during critical neurodevelopmental periods prevents behavioral and neurochemical deficits in the Poly I:C rat model of schizophrenia
Authors: Romero-Miguel Diego , Casquero-Veiga Marta , Lamanna-Rama Nicolás , Torres-Sánchez Sonia , MacDowell Karina S. , García-Partida José A. , Santa-Marta Cristina , Berrocoso Esther , Leza Juan C. , Desco Manuel , Soto-Montenegro María Luisa 
Published: January 2024

AbstractSchizophrenia is a chronic neurodevelopmental disorder with an inflammatory/prooxidant component. N-acetylcysteine (NAC) has been evaluated in schizophrenia as an adjuvant to antipsychotics, but its role as a preventive strategy has not been sufficiently explored. We aimed to evaluate the potential of NAC administration in two-time windows before the onset of symptoms in a schizophrenia-like maternal immune stimulation (MIS) rat model. Pregnant Wistar rats were injected with Poly I:C or Saline on gestational day (GD) 15. Three different preventive approaches were evaluated: 1) NAC treatment during periadolescence in the offspring (from postnatal day [PND] 35 to 49); 2) NAC treatment during pregnancy after MIS challenge until delivery (GD15–21); and 3) NAC treatment throughout all pregnancy (GD1–21). At postnatal day (PND) 70, prepulse inhibition (PPI) and anxiety levels were evaluated. In vivo magnetic resonance (MR) imaging was acquired on PND100 to assess structural changes in gray and white matter, and brain metabolite concentrations. Additionally, inflammation and oxidative stress (IOS) markers were measured ex vivo in selected brain regions. MIS offspring showed behavioral, neuroanatomical, and biochemical alterations. Interestingly, NAC treatment during periadolescence prevented PPI deficits and partially counteracted some biochemical imbalances. Moreover, NAC treatments during pregnancy not only replicated the beneficial outcomes reported by the treatment in periadolescence, but also prevented some neuroanatomical deficits, including reductions in hippocampal and corpus callosum volumes. This study suggests that early reduction of inflammation and prooxidation could help prevent the onset of schizophrenia-like symptoms, supporting the importance of anti-IOS compounds in ameliorating this disorder.
Olanzapine, risperidone and ziprasidone differently affect lysosomal function and autophagy, reflecting their different metabolic risk in patients
Authors: Pozzi Marco , Vantaggiato Chiara , Brivio Francesca , Orso Genny , Bassi Maria Teresa 
Published: January 2024

AbstractThe metabolic effects induced by antipsychotics in vitro depend on their action on the trafficking and biosynthesis of sterols and lipids. Previous research showed that antipsychotics with different adverse effects in patients cause similar alterations in vitro, suggesting the low clinical usefulness of cellular studies. Moreover, the inhibition of peripheral AMPK was suggested as potential aetiopathogenic mechanisms of olanzapine, and different effects on autophagy were reported for several antipsychotics. We thus assessed, in clinically-relevant culture conditions, the aetiopathogenic mechanisms of olanzapine, risperidone and ziprasidone, antipsychotics with respectively high, medium, low metabolic risk in patients, finding relevant differences among them. We highlighted that: olanzapine impairs lysosomal function affecting autophagy and autophagosome clearance, and increasing intracellular lipids and sterols; ziprasidone activates AMPK increasing the autophagic flux and reducing intracellular lipids; risperidone increases lipid accumulation, while it does not affect lysosomal function. These in vitro differences align with their different impact on patients. We also provided evidence that metformin add-on improved autophagy in olanzapine-treated cells and reduced lipid accumulation induced by both risperidone and olanzapine in an AMPK-dependent way; metformin also increased the production of bile acids to eliminate cholesterol accumulations caused by olanzapine. These results have different clinical implications. We demonstrated that antipsychotics with different metabolic impacts on patients actually have different mechanisms of action, thus supporting the possibility of a personalised antipsychotic treatment. Moreover, we found that metformin can fully revert the phenotype caused by risperidone but not the one caused by olanzapine, that still activates SREBP2.
Optogenetic recruitment of hypothalamic corticotrophin-releasing-hormone (CRH) neurons reduces motivational drive
Authors: Mitchell Caitlin S. , Campbell Erin J. , Fisher Simon D. , Stanton Laura M. , Burton Nicholas J. , Pearl Amy J. , McNally Gavan P. , Bains Jaideep S. , Füzesi Tamás , Graham Brett A. , Manning Elizabeth E. , Dayas Christopher V. 
Published: January 2024

AbstractImpaired motivational drive is a key feature of depression. Chronic stress is a known antecedent to the development of depression in humans and depressive-like states in animals. Whilst there is a clear relationship between stress and motivational drive, the mechanisms underpinning this association remain unclear. One hypothesis is that the endocrine system, via corticotropin-releasing hormone (CRH) in the paraventricular nucleus of the hypothalamus (PVN; PVNCRH), initiates a hormonal cascade resulting in glucocorticoid release, and that excessive glucocorticoids change brain circuit function to produce depression-related symptoms. Another mostly unexplored hypothesis is that the direct activity of PVNCRH neurons and their input to other stress- and reward-related brain regions drives these behaviors. To further understand the direct involvement of PVNCRH neurons in motivation, we used optogenetic stimulation to activate these neurons 1 h/day for 5 consecutive days and showed increased acute stress-related behaviors and long-lasting deficits in the motivational drive for sucrose. This was associated with increased Fos-protein expression in the lateral hypothalamus (LH). Direct stimulation of the PVNCRH inputs in the LH produced a similar pattern of effects on sucrose motivation. Together, these data suggest that PVNCRH neuronal activity may be directly responsible for changes in motivational drive and that these behavioral changes may, in part, be driven by PVNCRH synaptic projections to the LH.
The magnitude and variability of neurocognitive performance in first-episode psychosis: a systematic review and meta-analysis of longitudinal studies
Authors: Catalan Ana , McCutcheon Robert A. , Aymerich Claudia , Pedruzo Borja , Radua Joaquim , Rodríguez Victoria , Salazar de Pablo Gonzalo , Pacho Malein , Pérez Jose Luis , Solmi Marco , McGuire Philip , Giuliano Anthony J. , Stone William S. , Murray Robin M. , Gonzalez-Torres Miguel Angel , Fusar-Poli Paolo 
Published: January 2024

AbstractNeurocognitive deficits are a core feature of psychotic disorders, but it is unclear whether they affect all individuals uniformly. The aim of this systematic review and meta-analysis was to synthesize the evidence on the magnitude, progression, and variability of neurocognitive functioning in individuals with first-episode psychosis (FEP). A multistep literature search was conducted in several databases up to November 1, 2022. Original studies reporting on neurocognitive functioning in FEP were included. The researchers extracted the data and clustered the neurocognitive tasks according to the seven Measurement and Treatment Research to Improve Cognition in Schizophrenia (MATRICS) domains and six additional domains. Random-effect model meta-analyses, assessment of publication biases and study quality, and meta-regressions were conducted. The primary effect size reported was Hedges g of (1) neurocognitive functioning in individuals at FEP measuring differences with healthy control (HC) individuals or (2) evolution of neurocognitive impairment across study follow-up intervals. Of 30,384 studies screened, 54 were included, comprising 3,925 FEP individuals and 1,285 HC individuals. Variability analyses indicated greater variability in FEP compared to HC at baseline and follow-up. We found better neurocognitive performance in the HC group at baseline and follow-up but no differences in longitudinal neurocognitive changes between groups. Across the 13 domains, individuals with FEP showed improvement from baseline in all studied domains, except for visual memory. Metaregressions showed some differences in several of the studied domains. The findings suggest that individuals with FEP have marked cognitive impairment, but there is greater variability in cognitive functioning in patients than in HC. This suggests that subgroups of individuals suffer severe disease-related cognitive impairments, whereas others may be much less affected. While these impairments seem stable in the medium term, certain indicators may suggest potential further decline in the long term for a specific subgroup of individuals, although more research is needed to clarify this. Overall, this study highlights the need for tailored neurocognitive interventions for individuals with FEP based on their specific deficits and progression.
Persistent enhancement of basolateral amygdala-dorsomedial striatum synapses causes compulsive-like behaviors in mice
Authors: Lee In Bum , Lee Eugene , Han Na-Eun , Slavuj Marko , Hwang Jeong Wook , Lee Ahrim , Sun Taeyoung , Jeong Yehwan , Baik Ja-Hyun , Park Jae-Yong , Choi Se-Young , Kwag Jeehyun , Yoon Bong-June 
Published: January 2024

AbstractCompulsive behaviors are observed in a range of psychiatric disorders, however the neural substrates underlying the behaviors are not clearly defined. Here we show that the basolateral amygdala-dorsomedial striatum (BLA-DMS) circuit activation leads to the manifestation of compulsive-like behaviors. We revealed that the BLA neurons projecting to the DMS, mainly onto dopamine D1 receptor-expressing neurons, largely overlap with the neuronal population that responds to aversive predator stress, a widely used anxiogenic stressor. Specific optogenetic activation of the BLA-DMS circuit induced a strong anxiety response followed by compulsive grooming. Furthermore, we developed a mouse model for compulsivity displaying a wide spectrum of compulsive-like behaviors by chronically activating the BLA-DMS circuit. In these mice, persistent molecular changes at the BLA-DMS synapses observed were causally related to the compulsive-like phenotypes. Together, our study demonstrates the involvement of the BLA-DMS circuit in the emergence of enduring compulsive-like behaviors via its persistent synaptic changes.