bluuebunny/crossref_metadata_2025_split huggingface dataset:
Effect of data harmonization of multicentric dataset in ASD/TD classification
Authors: Serra Giacomo , Mainas Francesca , Golosio Bruno , Retico Alessandra , Oliva Piernicola 
Published: November 2023

AbstractMachine Learning (ML) is nowadays an essential tool in the analysis of Magnetic Resonance Imaging (MRI) data, in particular in the identification of brain correlates in neurological and neurodevelopmental disorders. ML requires datasets of appropriate size for training, which in neuroimaging are typically obtained collecting data from multiple acquisition centers. However, analyzing large multicentric datasets can introduce bias due to differences between acquisition centers. ComBat harmonization is commonly used to address batch effects, but it can lead to data leakage when the entire dataset is used to estimate model parameters. In this study, structural and functional MRI data from the Autism Brain Imaging Data Exchange (ABIDE) collection were used to classify subjects with Autism Spectrum Disorders (ASD) compared to Typical Developing controls (TD). We compared the classical approach (external harmonization) in which harmonization is performed before train/test split, with an harmonization calculated only on the train set (internal harmonization), and with the dataset with no harmonization. The results showed that harmonization using the whole dataset achieved higher discrimination performance, while non-harmonized data and harmonization using only the train set showed similar results, for both structural and connectivity features. We also showed that the higher performances of the external harmonization are not due to larger size of the sample for the estimation of the model and hence these improved performance with the entire dataset may be ascribed to data leakage. In order to prevent this leakage, it is recommended to define the harmonization model solely using the train set.
Antilithiatic effect of Triticum aestivum against sodium oxalate-induced lithiasis in rat model
Authors: Sayed Amany A. 
Published: November 2023

AbstractBackgroundThe present study pointed to evaluate the role ofTriticum aestivumethanolic extract (TAEE) in prophylactic and curative regimens on sodium oxalate (NaOx)-prompted lithiasis. Forty-eight rats were divided into the following regimen’s group (24 rats/regimen). Groups I, II, III, and IV served as prophylactic groups and divided as: group I is a vehicle control received 5% DMSO (vehicle). All the remaining groups received NaOx (70 mg/kg b.wt; i.p.). Group II is NaOx lithiatic group, groups III and IV received TAEE and cystone prophylactically at doses of 500 and 750 mg/kg b.wt, respectively, since 1st day to 7th day of lithiasis stimulation. Groups V, VI, VII, and VIII served as curative groups that divided as the prophylactic ones but TAEE and cystone administered from 7th day to 14th day of lithiasis stimulation.ResultsLithiatic rats co-/post-treated with TAEE and cystone raised the urinary volume significantly. Also, TAEE showed modulatory effect in inhibiting and curative stone creation. Significant decreases were observed in the calcium and phosphate contents in urine or serum beside the increased magnesium value in lithiatic rats co-/post-treated with TAEE. TAEE significantly ameliorates the kidney function markers, which proposes its antilithiatic role. Moreover, lithiatic rats co-/post-treated with TAEE significantly diminished oxidative injury evoked by NaOx.ConclusionsTAEE has antilithiatic role that may be returned to its diuretic and antioxidant activity in addition to its bioactive components including ferulic acid and phytic acid that have the inhibitory properties on crystallization calcium oxalate by lowering the content of stone promotor constituents.
Systematic review and research agenda for the tourism and hospitality sector: co-creation of customer value in the digital age
Authors: Dang T. D. , Nguyen M. T. 
Published: November 2023

Abstract
The tourism and hospitality industries are experiencing transformative shifts driven by the proliferation of digital technologies facilitating real-time customer communication and data collection. This evolution towards customer value co-creation demands a paradigm shift in management attitudes and the adoption of cutting-edge technologies like artificial intelligence (AI) and the Metaverse. A systematic literature review using the PRISMA method investigated the impact of customer value co-creation through the digital age on the tourism and hospitality sector. The primary objective of this review was to examine 27 relevant studies published between 2012 and 2022. Findings reveal that digital technologies, especially AI, Metaverse, and related innovations, significantly enhance value co-creation by allowing for more personalized, immersive, and efficient tourist experiences. Academic insights show the exploration of technology’s role in enhancing travel experiences and ethical concerns, while from a managerial perspective, AI and digital tools can drive industry success through improved customer interactions. As a groundwork for progressive research, the study pinpoints three pivotal focal areas for upcoming inquiries: technological, academic, and managerial. These avenues offer exciting prospects for advancing knowledge and practices, paving the way for transformative changes in the tourism and hospitality sectors.
Clinical Characteristics of Malignant Phosphaturic Mesenchymal Tumor Causing Tumor-Induced Osteomalacia
Authors: Abate Veronica , Vergatti Anita , De Filippo Gianpaolo , Damiano Vincenzo , Menale Ciro , D’Elia Lanfranco , Rendina Domenico 
Published: November 2023

Abstract

Context
Tumor-induced osteomalacia (TIO) is a rare paraneoplastic syndrome usually caused by oversecretion of fibroblast growth factor 23 (FGF23) from a phosphaturic mesenchymal tumor (PMT). PMTs are usually benign neoplasms but some of them show malignant characteristics.

Objective
The aim of this study was to compare the clinical characteristics of benign and malignant PMTs inducing TIO.

Methods
On March 31, 2023, we performed a systematic review of individual patient data analysis in Medline, Google Scholar, Google book, and Cochrane Library using the terms “tumor induced osteomalacia,” “oncogenic osteomalacia,” “hypophosphatemia,” with no language restrictions and according to Preferred Reporting Items for Systematic reviews and Meta-Analyses criteria.

Results
Overall, we collected data from 837 patients with TIO in which the diagnosis of benign and malignant PMT was specified. Of them, 89 were affected by malignant PMT and 748 by benign PMT. Patients with malignant PMTs were younger and presented bone pain, functional impairment, and bone deformities more frequently. Malignant PMTs showed higher values of intact FGF23 and a higher mortality rate.

Conclusion
The study results identify the clinical characteristics of patients with malignant TIO, permitting the early identification of patients with PMT at increased risk of malignancy. This may significantly improve the diagnostic approach to disease. Further experimental studies are mandatory to clarify the role of FGF23 in the pathogenesis of malignancy in PMTs.
Surgery as a Principle and Technical Consideration for Primary Tumor Resection of Small Bowel Neuroendocrine Tumors
Authors: Søreide Kjetil , Stättner Stefan , Hallet Julie 
Published: November 2023

AbstractSmall bowel neuroendocrine tumors (SB-NETs) are increasingly identified and have become the most frequent entity among small bowel tumors. An increasing incidence, a high prevalence, and a prolonged survival with optimal modern multidisciplinary management makes SB-NETs a unique set of tumors to consider for surgical oncologists. The major goals of surgical treatment in the setting of SB-NET include control of tumor volume, control of endocrine secretion, and prevention of locoregional complications. Key considerations include assessment of multifocality and resection of mesenteric nodal masses with the use of mesenteric-sparing approaches and acceptance of R1 margins if necessary to clear disease while avoiding short bowel syndrome. A description through eight steps for consideration is presented to allow for systematic surgical planning and execution of resection. Moreover, some controversies and evolving considerations to the surgical principles and technical procedures remain. The role of primary tumor resection in the presence of (unresectable) liver metastasis is still unclear. Reports of feasibility of minimally invasive surgery are emerging, with undetermined selection criteria for appropriateness or long-term outcomes. Resection of SB-NETs should be considered in all patients fit for surgery and should follow principles to achieve surgical oncological control that is appropriate for the stage and tumor burden, considering the age and comorbidity of the individual patient.
Evaluating the efficacy of a programme to educate nurses on CLABSI linked to total parenteral nutrition administration
Authors: Gaur Aditi , Natha Hepsi 
Published: November 2023

Background:There is a major need to improve the knowledge and practice of critical care nurses in India regarding central line-associated bloodstream infection (CLABSI), which is a serious potential complication of total parenteral nutrition (TPN).Objectives:To develop and validate a skills competency programme; assess knowledge and practice of critical care nurses regarding prevention of CLABSI due to TPN administration; evaluate the effectiveness of the programme; find correlation between knowledge and practice scores.Design:Quasi-experimental: non-equivalent pre-test post-test design.Settings:Two hospitals in Meerut, India.Participants:80 nurses (40 in the control group in one hospital, 40 in the experimental group in another hospital). Inclusion criteria: staff nurses from critical care units only, who were present at the time of data collection and willing to participate. Exclusion criteria: staff nurses with <6 months' work experience.Method:Knowledge was assessed using a structured knowledge questionnaire and interpretation scoring. To assess practice, the OSCE (objective structured clinical examination) method was used with four stations and interpretation scoring. The skills-competency programme was delivered to the experimental group only. The post test was conducted with both groups.Results:The post-test knowledge and practice scores in the control group were: mean=12.55; SD=2.57 and mean=21.82; SD= 5.13 respectively. In the experimental group, the post-test knowledge and practice scores were: mean=23.75; SD=1.75 and mean=38.9; SD=2.02 respectively. The unpaired t-test in post-test knowledge between the control and experimental groups was t=22.78, with P=0.0001 at df 39, 0.05 level of significance, 95% CI; for post-test practice the results were, t=19.59, with P=0.0001 at df 39, 0.05 level of significance, 95% CI. Correlation between post-test knowledge and the practice score was r=0.7 (P<0.05), 95% CI.Conclusion:There was a significant difference in post-test knowledge and practice scores, therefore, the skills competency programme was effective. It also highlighted areas that institutions should focus on for effective training and professional development programmes.
Selling Europe to the World: The Rise of the Luxury Industry, 1980–2020, Pierre Yves Donze (2023)
Authors: Arrington Deidra W. 
Published: November 2023

Review of: Selling Europe to the World: The Rise of the Luxury Industry, 1980–2020, Pierre Yves Donze (2023)
London: Bloomsbury Visual Arts, 166 pp.,
ISBN 978-1-35033-578-3, p/bk, $29.95
An analysis of critical success factors for product-service systems in an emerging economy
Authors: Beuren Fernanda Hänsch , Ferreira Marcelo Gitirana Gomes , Moro Suzana Regina , Cauchick-Miguel Paulo Augusto 
Published: November 2023

Goal: To identify and analyze critical success factors (CSF) related to product-service system (PSS) use and implementation.
Design / Methodology / Approach: Firstly, CSF were identified in literature and grouped in three PSS dimensions: (i) offering, (ii), consumer, and (iii) provider. Secondly, a questionnaire was applied to scholars to assess and prioritize those factors through field research. Finally, hypotheses were formulated and statistically verified through Kolmogorov-Smirnov tests.
Results: There is an agreement between the expert assessment and the literature on PSS. For instance, life-cycle perspective and PSS cost-benefit needed to be considered since PSS design. However, there are some contingencies about the product dematerialization, as well as to the reduction of environmental impacts.
Limitations of the investigation: The CSF were prioritized by the assessment of a limited number of scholars and practitioners from an emerging economy.
Practical implications: The CSF of PSS identified and prioritized in this work can offer directions the academics and practitioners, which intend to implement a PSS business model to establish and improve their practices.
Originality / Value: PSS is currently considered an alternative to mitigate environmental impacts since one of its purposes is consumption towards dematerialization. Although the concept of PSS has evolved in the past years, the literature is scarce of publications discussing the CSF that could favor its implementation, especially in developing countries.
P2X7 accelerate tissue fibrosis via metalloproteinase 8‐dependent macrophage infiltration in a murine model of unilateral ureteral obstruction
Authors: Therkildsen Jacob Rudjord , Tingskov Stine Julie , Jensen Michael Schou , Praetorius Helle , Nørregaard Rikke 
Published: November 2023

AbstractRenal fibrosis is tightly associated with chronic kidney disease, irrespective of the underlying pathogenesis. We previously demonstrated mild antifibrotic effects of targeting the P2X7 receptor in a pyelonephritis model. Reduced P2X7R‐activation elevated the neutrophil‐to‐macrophage ratio, resulting in less matrix accumulation without affecting the initial tissue healing. Here, we test if this P2X7R‐dependent modification of matrix accumulation also applies to a noninfectious fibrosis model of unilateral ureteral obstruction (7dUUO) and whether the response is gender‐dependent. We found that P2X7−/− mice show reduced fibrosis compared to wild type after 7dUUO: the effect was most pronounced in females, with a 55% decrease in collagen deposition after 7dUUO (p < 0.0068). P2X7R deficiency did not affect early fibrosis markers (TGF‐β, α‐SMA) or the renal infiltration of neutrophils. However, a UUO‐induced increase in macrophages was observed in wildtypes only (p < 0.001), leaving the P2X7−/− mice with ≈50% fewer CD68+ cells in the renal cortex (p = 0.018). In males, 7dUUO triggered an increase in diffusely interstitial scattering of the profibrotic, macrophage‐attracting metalloproteinase MMP8 and showed significantly lower MMP8 tissue expression in both male and female P2X7−/− mice (p < 0.0008). Thus, the P2X7R is advocated as a late‐stage fibrosis moderator by reducing neutrophil‐dependent interstitial MMP8 release, resulting in less macrophage infiltration and reduced matrix accumulation.
The medical treatment exclusion in Asia’s patent legislation
Authors: Adachi Kiyoshi 
Published: November 2023

Abstract
This study examines the variations within Asia of how Article 27.3(a) of the WTO Agreement on Trade-related Aspects of Intellectual Property Rights (the TRIPS Agreement), allowing Parties to remove from patentability diagnostic, therapeutic and surgical methods for the treatment of humans and animals, is implemented. The medical treatment exclusion is one of several important provisions in the TRIPS Agreement that are designed to support domestic public health objectives and countries’ overall scientific and technological aspirations. Examples of this exclusion in the respective patent policies of South, Southeast and East Asia countries and territories are examined, and peculiarities in the variations among countries in these sub-regions are identified. While most jurisdictions in the data set incorporated some form of a medical treatment exclusion, variations were found in how the exclusion is implemented, the rationale given for excluding medical treatments, and the scope of the exclusion.
Eigenvalue-curve approach for fast assessment of rotor angle transient stability
Authors: Wolter Martin , Glende Eric 
Published: November 2023

Abstract
The phase-out of nuclear and coal-based electricity production and their replacement by power-electronics based renewable energy sources, especially in Germany, leads to more and faster power system dynamics. Anyway, not all European countries plan to abandon bulk power generation, so there will still be a mix of inverter-based sources and synchronous machines in the future, justifying the necessity of rotor angle stability analysis. This task grows with the number of assets. It requires to numerically solve a large set of ordinary differential equations which gets more and more challenging to do in real-time during contingency analysis in power system operation. Therefore, this paper introduces a new approach to quickly estimate the transient stability of rotor angles without the need of solving differential equations. It is based on a linearized system description, some assumptions on the rotor angle displacement and uses the fault location and duration as parameters. It is proven, that this approach can be used to reduce the number of contingencies which need to be analyzed in detail during system operation and therefore helps transmission system operators to keep the power system stable and secure.
The Domestication of International Law in African Settings: Seven Normative Options in Ghana
Authors: Dei-Tutu Sena , Atuguba Raymond A 
Published: November 2023

Abstract
In this article, we explore seven ways in which Ghana absorbs principles of International Law into her bosom. The safest mechanism Ghana has utilised over the years for this purpose has been the domestic ratification of international conventions through the mechanism of a law passed by her Parliament. Another mechanism is the ratification of such conventions by the passage of a Resolution by her Parliament. Furthermore, existing principles of Ghanaian law may coincide with principles of International Law. Again, principles of Customary International Law are considered a part of the Common Law of Ghana. There are also instances where Domestic Law incorporates International Law by reference. A sixth mechanism is where there is a lacuna in Ghanaian law regarding a particular issue and government officials and judges resort to principles of International Law to fill that void. Finally, International Law may find expression in domestic Ghanaian law where judges, in the process of elaborating on domestic legal principles, call in the principles of International Law.
Music and Storytelling at Rock Art Sites? The Archaeoacoustics of the Urkosh Area (Russian Altai)
Authors: Díaz-Andreu Margarita , Rozwadowski Andrzej , Pasalodos Raquel Jiménez , Santos da Rosa Neemias , Benítez-Aragón Daniel , Alvarez-Morales Lidia 
Published: November 2023

Abstract
In this article, the potential of archaeoacoustics for understanding past communities is discussed by looking at a range of acoustic parameters. Our case study is the Urkosh rock art area in the Ongudai district, Republic of Altai (Russia). The rock art of this area dates possibly from the Upper Palaeolithic and definitely from the Early Bronze Age (second half of the third millennium BCE). There are important periods in the Early Iron Age (first half of the first millennium BCE) and the medieval era, after which there are later additions up to the present day. Major and minor sites were tested, as well as some with no art. The results obtained from the tests conducted using the impulse response method indicate high values for sound clarity not only in the rock art sites but also in at least one nearby panel without rock art. Although these results cannot explain why rock art was produced precisely in specific locations, they objectively describe the acoustic conditions under which particular intangible cultural practices were probably organised in them. In particular we focus on storytelling and music, cultural practices for which there is a wealth of information in the ethnographic sources written about the area.
FIB4 score is increased in severe preeclampsia
Authors: Özer Serdar , Güneş Hakan , Özer Alev 
Published: November 2023

Abstract

Objectives
This study aims to investigate how the fibrosis index based on four factors (FIB-4) is altered in preeclampsia and whether the FIB-4 score differs with respect to the severity of preeclampsia and the presence of fetal and maternal adverse outcomes.

Methods
One hundred and forty-two patients with mild preeclampsia (34.6 %), one hundred and ninety patients who have preeclampsia with severe features (46.2 %), and 79 healthy pregnant controls (19.2 %) were included in the study. Fetal adverse outcomes occurred in 40.1 %, and maternal adverse outcomes only appeared as neurological symptoms in 20.5 % of the preeclampsia patients.

Results
Healthy controls had significantly lower FIB-4 scores than women with mild preeclampsia, and women with mild preeclampsia had significantly lower FIB-4 scores than women who had preeclampsia with severe features (respectively 0.58±0.29 vs. 0.68±0.44 vs. 1.93±4.92, p=0.003). The FIB-4 scores of preeclampsia patients with neurologic symptoms and preeclampsia patients with fetal adverse events were found to be similar to preeclampsia patients who did not have these problems. In ROC curve analysis, FIB-4 scores ≥0.758 indicated the presence of neurologic symptoms in preeclampsia patients, with a sensitivity of 0.66 and a specificity of 0.66 (p=0.004).

Conclusions
To the best of our knowledge, this is the first study to establish the FIB-4 scores of preeclampsia patients and determine if FIB-4 scores change with respect to maternal and fetal adverse outcomes. Our findings suggest that FIB-4 might be used to predict pregnancies destined to be complicated with preeclampsia and preeclampsia patients who are more likely to experience maternal and fetal adverse outcomes.
Peroxisome proliferator-activated receptor gamma and osteoprotegerin levels as an indicator and diagnostic predictor of endothelial dysfunction
Authors: Hatiboglu Songül , Yanar Fatih , Ozturk Alper , Basar Yılmaz , Aydogan Mehmet , Ozkok Elif , Demirel Seref , Salmayenli Nihal 
Published: November 2023

Abstract

Objectives
Peroxisome proliferator-activated receptor gamma (PPAR-γ) modifies many cellular processes that contribute to atherosclerosis. The increased concentrations of osteoprotegerin (OPG) are related with coronary artery disease, calcification in vascular tissue, advanced atherosclerosis, and diabetic complications has been informed. The aim of our study was to define the relation among PPAR-γ Pro12Ala and, OPG and PPAR-γ in Peripheral Vascular Disease (PVD) and hypertension (HT). Also, it was aim to investigate the relationship between flow-mediated dilatation (FMD) in HT and ankle brachial index (ABI) in PVD in terms of endothelial dysfunction (ED).

Methods
Fifty-four patients with HT, 47 with PVD, and 52 healthy for the controls were included. Blood samples were used for analyzing PPAR-γ and OPG by Enzyme-Linked Immunosorbent Assay (ELISA), and biochemical assays. The PPAR-γ Pro12Ala was examined using TaqMan with PrimerProbMix. p value less than 0.05 was accepted as the limit of significance.

Results
The PPAR-γ was significantly decreased in both HT and PVD (p<0.001). The serum concentrations of OPG were higher in HT (p<0.001) and increased in diabetic ones (p<0.05). CG genotype of PPAR-γ Pro12Ala was more frequent in HT patients (p<0.001). In the HT patients, increased OPG and decreased PPAR-γ were found in CC (p<0.001). In the PVD patients, PPAR-γ levels decreased in carrying with CC (p<0.05).

Conclusions
It may be significant that increased OPG, as a marker of endothelial dysfunction, is found in HT. Moreover, decreased PPAR-γ in those who have to carry CC may be protective in both HT and PVD.