bluuebunny/crossref_metadata_2025_split huggingface dataset:
A wideband, thin, dual-negative, and polarization-independent square-tooth circular ring resonator-based metamaterial absorber for Ku-band applications
Authors: Amugothu Ramesh , Damera Vakula 
Published: February 2024

AbstractIn the proposed paper, a novel design and realization of a wide-band, oblique angle-insensitive metamaterial absorbers are presented. The absorber is designed to work over a wide range of frequencies, making it suitable for Ku-band applications. To get wide band absorption, a novel SM-shaped design with a square-tooth circular ring resonator structure is designed efficiently. The unit cell structure is designed with a dielectric substrate (FR4) with a thickness of 3.2 mm (0.16λ0), where λ0 is the wavelength of free space. The novel design of this configuration leads to wideband absorption with respect to a conventional absorber. Several physical parameters are also investigated, such as the dielectric constant, permittivity, permeability, impedance, and negative refractive index. The simulation and experimental results show from 13.60 to 16.14 GHz with 99.1% absorption, which is excellent agreement. The analysis of the proposed design indicates that it possesses the remarkable feature of being insensitive to polarization while also exhibiting high absorption even when the angle of incidence varies. For both the simulation and experiment, results are consistent with a frequency range of 13.60–16.14 GHz for normal incidence. Almost perfect absorption works well for solar cells, EM detection, and imaging applications.
The Degree of Homogeneity Versus Heterogeneity in Individuals’ Political News Consumption
Authors: Sindermann Cornelia , Montag Christian , Elhai Jon D. 
Published: February 2024

Abstract: This work investigated the prevalence of filter bubble or echo chamber-related phenomena, psychological factors rendering individuals resilient or vulnerable to them, and their associations to political views focusing on extremity and polarization. For this, a cross-cultural replication of a study by Sindermann et al. (2021) was conducted. As an extension, multiple political views variables were assessed to examine whether the application of different conceptualizations of political views explains heterogeneous findings across previous studies. Two samples were recruited: 390 ( n = 135 males) US college students and a quota sample of 489 ( n = 243 males) US adults. Participants completed personality scales and measures on political news consumption homogeneity versus heterogeneity and political views. Consistent with previous research, results revealed few individuals consume political news absolutely homogeneously. Openness was negatively related to the degree of political news consumption homogeneity, and the relationship between political news consumption homogeneity and political views yielded inconsistent, often statistically nonsignificant, results. These findings challenge the prevailing notion of filter bubbles and echo chambers as widespread phenomena and indicate that relationships between political news consumption homogeneity and political views are not necessarily deleterious with respect to extremization and polarization. As such, the results suggest that these phenomena might not be as significant for the general population as previously thought. Nonetheless, certain individuals might still find themselves in filter bubbles or echo chambers and suffer from accompanying consequences. In this regard, the present work replicates findings underscoring that individuals with lower Openness exhibit greater political news consumption homogeneity.
Vertical Wind Profiles in the Mesosphere and Lower Thermosphere Driven by Meteor Radar and Ionospheric Connection Explorer Observations Over the Korean Peninsula
Authors: Lee Jaewook , Kwak Young‐Sil , Kam Hosik , Kil Hyosub , Park Jaeheung , Kim Jeongheon , Yang Tae‐Yong , Lee Changsup 
Published: February 2024

AbstractMeteor radar observations provide wind data ranging from 80 to 100 km altitude, while the Michaelson Interferometer for Global High‐resolution Thermospheric Imaging (MIGHTI) onboard the Ionospheric Connection Explorer satellite offers wind data above 90 km altitude. This study aims to generate wind profiles in the mesosphere and lower thermosphere by combining the winds derived from meteor radar and MIGHTI observations over the Korean Peninsula from January 2020 to December 2021. The wind profiles derived from the two instruments are continuous at night, but they show discrepancies during the day. The atomic oxygen 557.7 nm (green line) emission intensity measured by MIGHTI peaks at approximately 100 km during the day and 94 km at night. The vertical gradient of the airglow volume emission rate is more pronounced during the day. These differences can cause day‐night differences in the MIGHTI wind retrieval accuracy, potentially leading to discrepancies during the day.
2021–2023 Unrest and Geodetic Observations at Askja Volcano, Iceland
Authors: Parks Michelle M. , Sigmundsson Freysteinn , Drouin Vincent , Hreinsdóttir Sigrún , Hooper Andrew , Yang Yilin , Ófeigsson Benedikt G. , Sturkell Erik , Hjartardóttir Ásta R. , Grapenthin Ronni , Geirsson Halldór , Trasatti Elisa , Barsotti Sara , Pedersen Rikke , Einarsson Páll , Óladóttir Bergrún A. , Friðriksdóttir Hildur M. 
Published: February 2024

AbstractUnrest began in July 2021 at Askja volcano in the Northern Volcanic Zone (NVZ) of Iceland. Its most recent eruption, in 1961, was predominantly effusive and produced ∼0.1 km3 lava field. The last plinian eruption at Askja occurred in 1875. Geodetic measurements between 1983 and 2021 detail subsidence of Askja, decaying in an exponential manner. At the end of July 2021, inflation was detected at Askja volcano, from GNSS observations and Sentinel‐1 interferograms. The inflationary episode can be divided into two periods from the onset of inflation until September 2023. An initial period until 20 September 2021 when geodetic models suggest transfer of magma (or magmatic fluids) from within the shallowest part of the magmatic system (comprising an inflating and deflating source), potentially involving silicic magma. A following period when one source of pressure increase at shallow depth can explain the observations.
Role of the histone variant H2A.Z.1 in memory, transcription, and alternative splicing is mediated by lysine modification
Authors: Reda Anas , Hategan Luca A. , McLean Timothy A. B. , Creighton Samantha D. , Luo Jian Qi , Chen Sean En Si , Hua Shan , Winston Stephen , Reeves Isaiah , Padmanabhan Aditya , Dahi Tarkan A. , Ramzan Firyal , Brimble Mark A. , Murphy Patrick J. , Walters Brandon J. , Stefanelli Gilda , Zovkic Iva B. 
Published: February 2024

AbstractCreating long-lasting memories requires learning-induced changes in gene expression, which are impacted by epigenetic modifications of DNA and associated histone proteins. Post-translational modifications (PTMs) of histones are key regulators of transcription, with different PTMs producing unique effects on gene activity and behavior. Although recent studies implicate histone variants as novel regulators of memory, effects of PTMs on the function of histone variants are rarely considered. We previously showed that the histone variant H2A.Z suppresses memory, but it is unclear if this role is impacted by H2A.Z acetylation, a PTM that is typically associated with positive effects on transcription and memory. To answer this question, we used a mutation approach to manipulate acetylation on H2A.Z without impacting acetylation of other histone types. Specifically, we used adeno-associated virus (AAV) constructs to overexpress mutated H2A.Z.1 isoforms that either mimic acetylation (acetyl-mimic) by replacing lysines 4, 7 and 11 with glutamine (KQ), or H2A.Z.1 with impaired acetylation (acetyl-defective) by replacing the same lysines with alanine (KA). Expressing the H2A.Z.1 acetyl-mimic (H2A.Z.1KQ) improved memory under weak learning conditions, whereas expressing the acetyl-defective H2A.Z.1KA generally impaired memory, indicating that the effect of H2A.Z.1 on memory depends on its acetylation status. RNA sequencing showed that H2A.Z.1KQ and H2A.Z.1KA uniquely impact the expression of different classes of genes in both females and males. Specifically, H2A.Z.1KA preferentially impacts genes involved in synaptic function, suggesting that acetyl-defective H2A.Z.1 impairs memory by altering synaptic regulation. Finally, we describe, for the first time, that H2A.Z is also involved in alternative splicing of neuronal genes, whereby H2A.Z depletion, as well as expression of H2A.Z.1 lysine mutants influence transcription and splicing of different gene targets, suggesting that H2A.Z.1 can impact behavior through effects on both splicing and gene expression. This is the first study to demonstrate that direct manipulation of H2A.Z post-translational modifications regulates memory, whereby acetylation adds another regulatory layer by which histone variants can fine tune higher brain functions through effects on gene expression and splicing.
Approaches to protocol standardization and data harmonization in the ECHO-wide cohort study
Authors: Jacobson Lisa P. , Parker Corette B. , Cella David , Mroczek Daniel K. , Lester Barry M. ,   on behalf of program collaborators for Environmental influences on Child Health Outcomes, Smith P. B. , Newby K. L. , Catellier D. J. , Gershon R. , Cella D. 
Published: February 2024

AbstractThe United States (U.S.) National Institutes of Health–funded Environmental influences on Child Health Outcomes (ECHO)-wide Cohort was established to conduct high impact, transdisciplinary science to improve child health and development. The cohort is a collaborative research design in which both extant and new data are contributed by over 57,000 children across 69 cohorts. In this review article, we focus on two key challenging issues in the ECHO-wide Cohort: data collection standardization and data harmonization. Data standardization using a Common Data Model and derived analytical variables based on a team science approach should facilitate timely analyses and reduce errors due to data misuse. However, given the complexity of collaborative research designs, such as the ECHO-wide Cohort, dedicated time is needed for harmonization and derivation of analytic variables. These activities need to be done methodically and with transparency to enhance research reproducibility.ImpactMany collaborative research studies require data harmonization either prior to analyses or in the analyses of compiled data.The Environmental influences on Child Health Outcomes (ECHO) Cohort pools extant data with new data collection from over 57,000 children in 69 cohorts to conduct high-impact, transdisciplinary science to improve child health and development, and to provide a national database and biorepository for use by the scientific community at-large.We describe the tools, systems, and approaches we employed to facilitate harmonized data for impactful analyses of child health outcomes.
Congenital anomalies and predisposition to severe COVID-19 among pediatric patients in the United States
Authors: Goodman Laura F. , Yu Peter T. , Guner Yigit , Awan Saeed , Mohan Akhil , Ge Kevin , Chandy Mathew , Sánchez Mario , Ehwerhemuepha Louis 
Published: February 2024

Abstract
Background and objective
Congenital heart defects are known to be associated with increased odds of severe COVID-19. Congenital anomalies affecting other body systems may also be associated with poor outcomes. This study is an exhaustive assessment of congenital anomalies and odds of severe COVID-19 in pediatric patients.

Methods
Data were retrieved from the COVID-19 dataset of Cerner® Real-World Data for encounters from March 2020 to February 2022. Prior to matching, the data consisted of 664,523 patients less than 18 years old and 927,805 corresponding encounters with COVID-19 from 117 health systems across the United States. One-to-one propensity score matching was performed, and a cumulative link mixed-effects model with random intercepts for health system and patients was built to assess corresponding associations.

Results
All congenital anomalies were associated with worse COVID-19 outcomes, with the strongest association observed for cardiovascular anomalies (odds ratio [OR], 3.84; 95% CI, 3.63–4.06) and the weakest association observed for anomalies affecting the eye/ear/face/neck (OR, 1.16; 95% CI, 1.03–1.31).

Conclusions and relevance
Congenital anomalies are associated with greater odds of experiencing severe symptoms of COVID-19. In addition to congenital heart defects, all other birth defects may increase the odds for more severe COVID-19.

Impact

All congenital anomalies are associated with increased odds of severe COVID-19.

This study is the largest and among the first to investigate birth defects across all body systems.

The multicenter large data and analysis demonstrate the increased odds of severe COVID19 in pediatric patients with congenital anomalies affecting any body system. These data demonstrate that all children with birth defects are at increased odds of more severe COVID-19, not only those with heart defects. This should be taken into consideration when optimizing prevention and intervention resources within a hospital.
The serum thioredoxin-1 levels are not associated with bronchopulmonary dysplasia and retinopathy of prematurity
Authors: Haga Mitsuhiro , Nagano Nobuhiko , Ozawa Junichi , Tanaka Kosuke , Miyahara Naoyuki , Fujimoto Takeshi , Ishii Kuniya , Namba Fumihiko 
Published: February 2024

Abstract
Background
We hypothesized that the serum TRX-1 in extremely preterm infants (EPIs) after birth was associated with the development of severe bronchopulmonary dysplasia (BPD) and retinopathy of prematurity (ROP).

Methods
This single-centered retrospective study enrolled EPIs treated at our institution. Serum TRX-1 concentrations of the residual samples taken on admission, day 10–20 of life, and 36–40 weeks of postmenstrual age (PMA) were measured with an enzyme-linked immunosorbent assay.

Results
The serum TRX-1 levels on admission were not different between the severe BPD (n = 46) and non-severe BPD groups (n = 67): [median (interquartile range) 147 (73.0–231) vs. 164 (80.5–248) ng/mL] (P = 0.57). These had no significant difference between the severe ROP (n = 47) and non-severe ROP groups (n = 66): [164 (71.3–237) vs. 150 (80.9–250) ng/mL] (P = 0.93). The TRX-1 levels at 10–20 days of life and 36–40 weeks of PMA also had no association with the development of severe BPD and ROP.

Conclusion
The serum TRX-1 levels after birth are not predictive of severe BPD and ROP.

Impact

Serum thioredoxin-1 levels in extremely preterm infants on the day of birth are lower than those in term or near-term infants hospitalized for transient tachypnea of the newborn.

In extremely preterm infants, the serum thioredoxin-1 levels on the day of birth, at 10–20 days of life, and at postmenstrual age of 36–40 weeks were not associated with severe bronchopulmonary dysplasia and retinopathy of prematurity.

The thioredoxin system is under development in extremely preterm infants; however, the serum thioredoxin-1 level is not predictive for severe bronchopulmonary dysplasia and retinopathy of prematurity.
From the regulatory mechanism of TFEB to its therapeutic implications
Authors: Chen Huixia , Gong Siqiao , Zhang Hongyong , Chen Yongming , Liu Yonghan , Hao Junfeng , Liu Huafeng , Li Xiaoyu 
Published: February 2024

AbstractTranscription factor EB (TFEB), known as a major transcriptional regulator of the autophagy-lysosomal pathway, regulates target gene expression by binding to coordinated lysosomal expression and regulation (CLEAR) elements. TFEB are regulated by multiple links, such as transcriptional regulation, post-transcriptional regulation, translational-level regulation, post-translational modification (PTM), and nuclear competitive regulation. Targeted regulation of TFEB has been victoriously used as a treatment strategy in several disease models such as ischemic injury, lysosomal storage disorders (LSDs), cancer, metabolic disorders, neurodegenerative diseases, and inflammation. In this review, we aimed to elucidate the regulatory mechanism of TFEB and its applications in several disease models by targeting the regulation of TFEB as a treatment strategy.
Garcinol prevents oxidative stress-induced bone loss and dysfunction of BMSCs through NRF2-antioxidant signaling
Authors: Zou Jilong , Chen Hongjun , Fan Xinming , Qiu Zhenrui , Zhang Jiale , Sun Jiabing 
Published: February 2024

AbstractThere are multiple published data showing that excessive oxidative stress contributes to bone loss and even bone tissue damage, and it is also correlated with the pathophysiology of bone degenerative diseases, including osteoporosis (OP). Garcinol, a polyisoprenylated benzophenone derivative, has been recently established as an anti-oxidant agent. However, it remains elusive whether Garcinol protects bone marrow mesenchymal stem cells (BMSCs) and bone tissue from oxidative stress-induced damage. Here, we explored the potential effects of Garcinol supplementation in ameliorating oxidative stimulation-induced dysfunction of BMSCs and bone loss in osteoporotic mice. In this study, we verified that Garcinol exerted potent protective functions in the hydrogen peroxide (H2O2)-induced excessive oxidative stress and dysfunction of BMSCs. Besides, Garcinol was also identified to improve the reduced bone mass and abnormal lineage commitment of BMSCs in the condition of OP by suppressing the oxidative stimulation. Subsequent analysis revealed that nuclear factor erythroid 2-related factor 2 (NRF2) might be a key regulator in the sheltering effects of Garcinol on the H2O2-regulated oxidative stress, and the protective functions of Garcinol was mediated by NRF2-antioxidant signaling. Collectively, Garcinol prevented oxidative stress-related BMSC damage and bone loss through the NRF2-antioxidant signaling, which suggested the promising therapeutic values of Garcinol in the treatment of oxidative stress-related bone loss. Therefore, Garcinol might contribute to treating OP.
Manipulation of the magnetic monopole injection for topological transition
Authors: Han Hee-Sung , Montoya Sergio A. , Fullerton Eric E. , Chao Weilun , Je Soong-Geun , Lee Ki‐Suk , Im Mi-Young 
Published: February 2024

Abstract
Manipulating the topological properties of spin textures in magnetic materials is of great interest due to the rich physics and promising technological applications of these materials in advanced electronic devices. A spin texture with desired topological properties can be created by magnetic monopole injection, resulting in topological transitions involving changes in the topological charge. Therefore, controlling magnetic monopole injection has paramount importance for obtaining the desired spin textures but has not yet been reported. Here, we report the use of reliably manipulated magnetic monopole injection in the topological transition from stripe domains to skyrmions in an Fe/Gd multilayer. An easily tunable in-plane magnetic field applied to an Fe/Gd multilayer plays a key role in the magnetic monopole injection by modulating the local exchange energy. Our findings facilitate the efficient management of topological transitions by providing an important method for controlling magnetic monopole injection.
An ultrasensitive and broadband transparent ultrasound transducer for ultrasound and photoacoustic imaging in-vivo
Authors: Cho Seonghee , Kim Minsu , Ahn Joongho , Kim Yeonggeun , Lim Junha , Park Jeongwoo , Kim Hyung Ham , Kim Won Jong , Kim Chulhong 
Published: February 2024

AbstractTransparent ultrasound transducers (TUTs) can seamlessly integrate optical and ultrasound components, but acoustic impedance mismatch prohibits existing TUTs from being practical substitutes for conventional opaque ultrasound transducers. Here, we propose a transparent adhesive based on a silicon dioxide-epoxy composite to fabricate matching and backing layers with acoustic impedances of 7.5 and 4–6 MRayl, respectively. By employing these layers, we develop an ultrasensitive, broadband TUT with 63% bandwidth at a single resonance frequency and high optical transparency ( > 80%), comparable to conventional opaque ultrasound transducers. Our TUT maximises both acoustic power and transfer efficiency with maximal spectrum flatness while minimising ringdowns. This enables high contrast and high-definition dual-modal ultrasound and photoacoustic imaging in live animals and humans. Both modalities reach an imaging depth of > 15 mm, with depth-to-resolution ratios exceeding 500 and 370, respectively. This development sets a new standard for TUTs, advancing the possibilities of sensor fusion.
SEL1L-HRD1 interaction is required to form a functional HRD1 ERAD complex
Authors: Lin Liangguang Leo , Wang Huilun Helen , Pederson Brent , Wei Xiaoqiong , Torres Mauricio , Lu You , Li Zexin Jason , Liu Xiaodan , Mao Hancheng , Wang Hui , Zhou Linyao Elina , Zhao Zhen , Sun Shengyi , Qi Ling 
Published: February 2024

AbstractThe SEL1L-HRD1 protein complex represents the most conserved branch of endoplasmic reticulum (ER)-associated degradation (ERAD). Despite recent advances in both mouse models and humans, in vivo evidence for the importance of SEL1L in the ERAD complex formation and its (patho-)physiological relevance in mammals remains limited. Here we report thatSEL1Lvariantp.Ser658Pro(SEL1LS658P) is a pathogenic hypomorphic mutation, causing partial embryonic lethality, developmental delay, and early-onset cerebellar ataxia in homozygous mice carrying the bi-allelic variant. Biochemical analyses reveal thatSEL1LS658Pvariant not only reduces the protein stability of SEL1L, but attenuates the SEL1L-HRD1 interaction, likely via electrostatic repulsion between SEL1L F668 and HRD1 Y30 residues. Proteomic screens of SEL1L and HRD1 interactomes reveal that SEL1L-HRD1 interaction is a prerequisite for the formation of a functional HRD1 ERAD complex, as SEL1L is required for the recruitment of E2 enzyme UBE2J1 as well as DERLIN to HRD1. These data not only establish the disease relevance of SEL1L-HRD1 ERAD, but also provide additional insight into the formation of a functional HRD1 ERAD complex.
Non-invasive modulation of meningeal lymphatics ameliorates ageing and Alzheimer’s disease-associated pathology and cognition in mice
Authors: Wang Miao , Yan Congcong , Li Xi , Yang Tianhao , Wu Shengnan , Liu Qian , Luo Qingming , Zhou Feifan 
Published: February 2024

AbstractMeningeal lymphatic vessels (mLVs) have been shown to be involved in amyloid beta (Aβ) clearance, which is considered as a potential therapeutic target for Alzheimer’s disease (AD). In this study, based on the superficial spatial distribution of mLVs, a near-infrared light is employed to modulate lymphatic drainage, significantly improving cognition of both aged and AD (5xFAD and APP/PS1) mice, and alleviating AD-associated pathology by reducing Aβ deposition, neuroinflammation and neuronal damage. Furthermore, transmission electron microscopy imaging and RNA sequencing data indicate amelioration of mitochondrial metabolism and cellular junction of meningeal lymphatic endothelial cells (mLECs) by light modulation. These studies collectively suggest that near-infrared light treatment can improve cognitive function by strengthening scavenging ability of mLVs through restoring mLEC function. In conclusion, lymphatic drainage potentiation by light promotes pathological remission and cognitive enhancement in aging and AD mouse models, which offers a potential amelioration strategy for neurodegenerative diseases.