bluuebunny/crossref_metadata_2025_split huggingface dataset:
A predictive analytics framework for sensor data using time series and deep learning techniques
Authors: Selmy Hend A. , Mohamed Hoda K. , Medhat Walaa 
Published: January 2024

AbstractIoT devices convert billions of objects into data-generating entities, enabling them to report status and interact with their surroundings. This data comes in various formats, like structured, semi-structured, or unstructured. In addition, it can be collected in batches or in real time. The problem now is how to benefit from all of this data gathered by sensing and monitoring changes like temperature, light, and position. In this paper, we propose a predictive analytics framework constructed on top of open-source technologies such as Apache Spark and Kafka. The framework focuses on forecasting temperature time series data using traditional and deep learning predictive analytics methods. The analysis and prediction tasks were performed using Autoregressive Integrated Moving Average (ARIMA), Seasonal Autoregressive Integrated Moving Average (SARIMA), Long Short-Term Memory (LSTM), and a novel hybrid model based on Convolution Neural Network (CNN) and LSTM. The purpose of this paper is to determine whether and how recently developed deep learning-based models outperform traditional algorithms in the prediction of time series data. The empirical studies conducted and reported in this paper demonstrate that deep learning-based models, specifically LSTM and CNN-LSTM, exhibit superior performance compared to traditional-based algorithms, ARIMA and SARIMA. More specifically, the average reduction in error rates obtained by LSTM and CNN-LSTM models were substantial when compared to other models indicating the superiority of deep learning. Moreover, the CNN-LSTM-based deep learning model exhibits a higher degree of closeness to the actual values when compared to the LSTM-based model.
Preoperative estimation of intracranial compliance in symptomatic children with Chiari malformation type 1: impact on outcome and risk of complications
Authors: Frič Radek , Bryne Eline , Warsza Bogna , Due-Tønnessen Bernt Johan , Eide Per Kristian 
Published: January 2024

Abstract

Background
The role of reduced intracranial compliance (ICC) in the outcome after foramen magnum decompression (FMD) was demonstrated in adults with Chiari malformation Type 1 (CMI). However, similar observations from children treated for CMI are missing.

Methods
We reviewed pediatric cases of CMI referred to FMD between 2006 and 2022. Children with clinical and/or radiological signs suggesting reduced ICC (Group A) underwent overnight measurements of the pulsatile intracranial pressure (ICP): mean ICP wave amplitude (MWA) served as a surrogate marker of ICC. Children with more typical symptoms of CMI (Group B) underwent FMD without preoperative ICC estimation. This study presents the clinical, radiological, and outcome differences between these groups.

Results
Sixty-four children (mean age 11.1 ± 4.3 years) underwent FMD: In Group A (n = 30), the finding of reduced ICC as estimated from preoperative ICP measurement resulted in CSF diversion (ventriculoperitoneal shunt) before FMD in 11 children. Two patients required shunt due to complications after FMD (total shunt rate 43%). In Group B (n = 34) treated with FMD without preoperative ICC estimation, five children (15%) required shunting due to complications. In Group A, we found a significantly higher frequency of headache, nausea, fatigue, and dizziness. The outcome assessed by the modified Chicago Chiari Outcome Scale (mean follow-up 83 ± 57 months) was comparable between the groups, but the complication rate after FMD was significantly lower in Group A (7% vs. 32%; p = 0.011). The number of procedures (ICP measurement, FMD, shunt, re-do FMD, shunt revisions) was significantly higher in Group A (2.6 ± 0.9 vs. 1.5 ± 1.1 per patient; p < 0.001).

Conclusion
In symptomatic children with CMI, the preoperative estimation of ICC from the overnight measurement of pulsatile ICP was more reliable for identifying those with reduced ICC than clinical and radiological assessment alone. When children with abnormally reduced ICC were identified and treated with CSF diversion before FMD, the complication rate was significantly reduced.
Availability and mobilization of forest resources in Sweden
Authors: Eriksson Andreas , Eggers Jeannette , Claesson Svante , Fridman Jonas , Nylander Martin , Olsson Patrik , Öhman Karin , Nordström Eva-Maria 
Published: January 2024

AbstractThe available amount of wood supply is essential for national strategic planning and evaluation of forestry in Sweden. Since Sweden holds a large part of the forests in the European Union and plays a significant role in the global trade of wood-based products, a precise estimate of the potential of the Swedish forest resource is also important in regional and global outlook studies. In this study, we analyse factors influencing the availability and mobilization of wood supply. By comparing data from the Swedish National Forest Inventory with the stand registers of the five largest forest owners in Sweden, we estimate the productive forest area not included in the forest owners' stand databases. Our results show that 0.4 million hectares, or 5% of these large-scale forest owners productive forest area, is outside their stand registers and therefore neither included in their long-term harvesting plans nor in their nature conservation plans. For small-scale forest owners, we analyse the final felling rate during 2004–2020 using satellite imagery to estimate the proportion of properties that abstain from final fellings and thereby could affect the potential mobilization of wood supply. During this period, 32% of the forest properties owned by small-scale forest owners have not done any final felling. These forest estates hold in total 1.1 million hectares of productive forest land or 9% of the area owned by small-scale forest owners. This implies a gap between the potential and realistic estimates for Forest Available for Wood Supply.
Destructive impact of successive high magnitude earthquakes occurred in Türkiye’s Kahramanmaraş on February 6, 2023
Authors: Demir Aydin , Celebi Erkan , Ozturk Hakan , Ozcan Zeki , Ozocak Askin , Bol Ertan , Sert Sedat , Sahin F. Zehra , Arslan Eylem , Dere Yaman Zeynep , Utkucu Murat , Mert Necati 
Published: January 2024

AbstractTwo successive earthquakes with moment magnitudes of Mw = 7.7 (focal depth = 8.6 km) and Mw = 7.6 (focal depth = 7 km) occurred approximately within 9 h on February 6, 2023, in Türkiye, respectively. The epicenters were the Pazarcık and Elbistan districts of Kahramanmaraş. Both earthquakes occurred in the East Anatolian Fault Zone, one of Türkiye’s two major active fault systems. Between these two severe earthquakes, there was one more big aftershock with a moment magnitude of 6.6, the epicenter of which was in the Nurdağı District of Gaziantep. Then, on February 20, 2023, another aftershock earthquake with a magnitude of Mw = 6.4 occurred in Yayladağı district of Hatay. As a result of the earthquakes, severe damage occurred in several provinces and districts with a population of around 15 million, and more than 50,000 people have lost their lives. This study presents on-site geotechnical and structural investigations by a team of researchers after the Kahramanmaraş earthquakes. It summarizes the performance of the building environments as a result of on-site assessments, taking into account observed structural damage, local site conditions, and strong ground motion data. The possible causes of the observed damage are addressed in detail. These earthquakes once again revealed the common deficiencies of existing reinforced concrete structures in Türkiye, such as poor material quality, poor workmanship, unsuitability of reinforcement detailing, and inadequate earthquake-resistant construction techniques. Precast concrete and masonry structures in the region were also severely damaged during the earthquakes due to insufficient engineering service, poor materials, deficiencies during construction, etc.
Molecular mechanisms and emerging therapies in wild-type transthyretin amyloid cardiomyopathy
Authors: Wu Danni , Chen Wei 
Published: January 2024

AbstractWild-type transthyretin amyloid cardiomyopathy (ATTRwt-CM) is an underrecognized cause of heart failure due to misfolded wild-type transthyretin (TTRwt) myocardial deposition. The development of wild-type TTR amyloid fibrils is a complex pathological process linked to the deterioration of homeostatic mechanisms owing to aging, plausibly implicating multiple molecular mechanisms. The components of amyloid transthyretin often include serum amyloid P, proteoglycans, and clusterin, which may play essential roles in the localization and elimination of amyloid fibrils. Oxidative stress, impaired mitochondrial function, and perturbation of intracellular calcium dynamics induced by TTR contribute to cardiac impairment. Recently, tafamidis has been the only drug approved by the U.S. Food and Drug Administration (FDA) for the treatment of ATTRwt-CM. In addition, small interfering RNAs and antisense oligonucleotides for ATTR-CM are promising therapeutic approaches and are currently in phase III clinical trials. Newly emerging therapies, such as antibodies targeting amyloid, inhibitors of seed formation, and CRISPR‒Cas9 technology, are currently in the early stages of research. The development of novel therapies is based on progress in comprehending the molecular events behind amyloid cardiomyopathy. There is still a need to further advance innovative treatments, providing patients with access to alternative and effective therapies, especially for patients diagnosed at a late stage.
SMARCB1-Deficient Skull Base Chondrosarcoma with 12p Duplication Presenting as Somatic-Type Malignancy Arising from Metastatic Seminoma
Authors: Argyris Prokopios P. , Challa Bindu , Satturwar Swati , VanKoevering Kyle K. , Wakely Paul E. 
Published: January 2024

AbstractSomatic-type malignancy (STM) can occur infrequently within a primary or metastatic testicular germ cell tumor (TGCT) and is associated with dismal prognosis and survival. STM with chondrosarcomatous features is exceedingly rare and head and neck involvement has not been previously documented. A 39-year-old white man presented with nasal obstruction and epistaxis. Imaging disclosed a 6.9-cm expansile tumor involving the nasal cavity and skull base with intraorbital and intracranial extension. The histopathologic properties of the tumor were compatible with chondrosarcoma, grade II-III. Immunohistochemically, malignant cells were strongly and diffusely positive for S100 and epithelial markers, and showed loss of SMARCB1 expression. IDH1/2 mutations were not detected. Following whole-body PET scan, a 7.0-cm left testicular mass was discovered and diagnosed as seminoma with syncytiotrophoblastic cells, stage pT3NXM1b. Extensive retroperitoneal, mediastinal, and supraclavicular lymphadenopathy was also noticed. Histopathologic examination of the left supraclavicular lymph node revealed metastatic seminoma. By FISH, most metastatic nodal seminoma cells harbored 1 to 4 copies of isochromosome 12p, while the chondrosarcoma featured duplication of 12p. Presence of a malignant TGCT with disseminated supradiaphragmatic lymphadenopathy, the unique immunophenotypic properties of the skull-based chondrosarcoma and lack of IDH1/2 aberrations with gain of 12p strongly support the diagnosis of STM chondrosarcoma arising from metastatic TGCT. The patient did not respond to chemotherapy and succumbed three months after diagnosis. Although exceedingly uncommon, metastasis to the head and neck may occur in patients with TGCT. This case of STM chondrosarcoma demonstrated divergent immunophenotypic and molecular characteristics compared to “typical” examples of head and neck chondrosarcoma. High index of suspicion is advised regarding the diagnosis of lesions that present with otherwise typical histomorphology but unexpected immunohistochemical or molecular features.
Sponges and their prokaryotic communities sampled from a remote karst ecosystem
Authors: Cleary Daniel F. R. , Huang Yusheng M. , Polónia Ana R. M. , van der Plas Martin , Gomes Newton C. M. , de Voogd Nicole J. 
Published: January 2024

AbstractMarine karst ecosystems exist at the land-sea interface and are characterised by underwater formations sculpted over time by the action of seawater. Submerged caves and crevices of these ecosystems host a rich array of marine life of which sponges are among the most abundant and diverse components. In the present study, we describe elements of the sponge fauna sampled from a unique karst ecosystem at a remote island, Orchid Island, off the southeastern coast of Taiwan. The present study includes several understudied sponge taxa, including sclerosponges (Acanthochaetetes wellsi, and Astrosclera willeyana) and several lithistid species from dark, shallow-water caves. Prokaryotic communities were obtained from a total of 22 demosponge species, of which 11 are potentially new to science. The tetracladinid, lithistids harboured prokaryotic communities, which clustered separately from all other sponge species, contrasting with the non-tetracladinid, lithistid Vetulina incrustans. The tetracladinid, lithistids, furthermore, formed two distinct clusters with species of the Spirophorina suborder clustering apart from those of the Astrophorina suborder. The sclerosponge A. wellsi also harboured a distinct prokaryotic community in terms of composition including five unique, abundant OTUs with relatively low sequence similarities to organisms in GenBank. All cave sponges were enriched with SAR202 members, a group of bacteria known for their role in the degradation of recalcitrant compounds. The highest relative abundance of SAR202 was found in A. wellsi. We propose that the cave sponges of Orchid Island may play an as-yet uncharted role in nutrient dynamics at the land-sea interface.
Mycotoxin occurrence in kernels and straws of wheat, barley, and tritordeum
Authors: Gozzi Marco , Blandino Massimo , Bruni Renato , Capo Luca , Righetti Laura , Dall’Asta Chiara 
Published: January 2024

AbstractThirty-two varieties of common and durum wheat, hordeum, barley, and tritordeum collected over two harvesting years (2020 and 2021) were investigated for the presence of multiple Fusarium-related mycotoxins in asymptomatic plants. DON, 3-AcDON, 15-AcDON, T-2, HT-2, and ZEN together with the emerging mycotoxin ENN B and the major modified form of DON, namely DON3Glc, were quantified by means of UHPLC-MS/MS. Overall, DON and ENN B were the most frequently detected mycotoxins, albeit large inter-year variability was observed and related to different climate and weather conditions. Straws had higher mycotoxin contents than kernels and regarding DON occurrence tritordeum was found to be the most contaminated group on average for both harvesting years, while barley was the less contaminated one. Emerging mycotoxin ENN B showed comparable contents in kernels compared to straw, with a ratio close to 1 for tritordeum and barley. Regarding the occurrence of the other evaluated mycotoxins, T-2 and HT-2 toxins have been spotted in a few tritordeum samples, while ZEN has been frequently found only in straw from the harvesting year 2020. The data collected confirms the occurrence of multiple Fusarium mycotoxins in straws also from asymptomatic plants, highlighting concerns related to feed safety and animal health. The susceptibility of Tritordeum, hereby reported for the first time, suggests that careful measures in terms of monitoring, breeding, and cultural choices should be applied when dealing with his emerging crop.
Anti-prostate cancer mechanism of black ginseng during the "nine steaming and nine sun-drying" process based on HPLC analysis combined with vector space network pharmacology
Authors: Zhang Youran , Huang Ye , Dou Deqiang 
Published: January 2024

AbstractHPLC analysis determined six small-molecule organic acids, maltol, 5-hydroxymethylfurfural (5-HMF), 17 ginsenosides, four oligosaccharides, and 20 amino acids in black ginseng samples with different processing times. Based on the content determination results, the differential ingredients in the processing of black ginseng were screened by multivariate statistical analysis. Network pharmacological methods obtained the core targets and pathways of the above ingredients against prostate cancer. Finally, the entropy weight method was used to assign values to the above ingredients, targets, and pathways, and the vector space network pharmacology method was established to study the anti-prostate cancer mechanism of black ginseng in the process of "nine steaming and nine sun-drying". Based on principal component analysis (PCA) and orthogonal partial least squares discriminant analysis (OPLS-DA), fructose, glucose, dencichin, glutamate, ginsenoside 20 (S)-Rg3, 20 (R)-Rg3, 20 (S)-Rh2, Rg1, Re, and Rc were the main differential ingredients in various steaming and sun-drying cycle periods of black ginseng. The results of vector space network pharmacology showed that the main reason for the change in the anti-prostate cancer pathway of black ginseng with the number of steaming and sun-drying was the different regulatory ability of black ginseng on the PI3K-Akt signaling pathway and chemical carcinogenesis-receptor activation pathway. It gave researchers a fresh perspective for exploring the anti-prostate cancer active components of black ginseng and the change in the mechanism of the effect of traditional Chinese medicine in processing.
Breast cancer cells and adipocytes in hypoxia: metabolism regulation
Authors: Yu Xin , Zhang Tianqi , Cheng Xiaozhi , Ma Li 
Published: January 2024

AbstractAdipocytes play a significant role in breast cancer due to the unique histological structure of the breast. These have not only been detected adjacent to breast cancer cells but they have also been implicated in cancer development. Adipocytes in obese individuals and tumor microenvironment (TME) have a common feature, that is, hypoxia. The increased expression of hypoxia-inducible factor (HIF)-1α is known to alter the metabolism and functions of adipocytes. In this study, we described the mechanism linking the hypoxia-sensing pathway manifested by HIF to adipocytes and breast cancer and discussed the mechanism underlying the role of hypoxic adipocytes in breast cancer development from the perspective of metabolic remodeling. The processes and pathways in hypoxic adipocytes could be a promising target in breast cancer therapy.
Antiosteoporosis therapy after discontinuation of menopausal hormone therapy: a systematic review
Authors: Anagnostis Panagiotis , Divaris Efstathios , Bosdou Julia Κ. , Tournis Symeon , Stathopoulos Konstantinos , Goulis Dimitrios G. 
Published: January 2024

Abstract
Objective
Menopausal hormone therapy (MHT) has consistently shown a bone protective effect by reducing the risk of vertebral, non-vertebral, and hip fractures in postmenopausal women regardless of baseline fracture risk. However, the optimal sequential treatment after MHT discontinuation has not been determined. This systematic review aimed to obtain the best evidence regarding the effect of antiresorptive or osteoanabolic treatment on bone mineral density (BMD) and/or fracture risk following MHT.

Methods
A comprehensive search was conducted in the PubMed, Scopus, and Cochrane databases up to October 31, 2023. Randomized-controlled trials (RCTs) and observational studies conducted in postmenopausal women were included.

Results
After the exclusion of duplicates, 717 studies were identified. Two were eligible for qualitative analysis, one RCT and one retrospective cohort study. The RCT showed that alendronate 10 mg/day for 12 months further increased lumbar spine (LS) BMD by 2.3% following MHT and maintained femoral neck (FN) BMD in postmenopausal women (n = 144). It also decreased bone anabolic and resorption markers by 47 and 36%, respectively. In the retrospective study (n = 34), raloxifene 60 mg/day increased both LS and FN BMD at 12 months by 3 and 2.9%, respectively. No fractures were reported.

Conclusions
Antiresorptive therapy with either a bisphosphonate (i.e., alendronate) or raloxifene could be considered a sequential antiosteoporosis therapy after MHT withdrawal since they have been shown in studies to further increase BMD. However, no safe conclusions can be drawn from the existing literature.
Heterotopias of Citizenship as Spaces of Otherness: The Fluid Boundaries Between We and They
Authors: Lashchuk Iuliia 
Published: January 2024

AbstractHeterotopia is a neologism proposed by Michel Foucault to describe specific cultural and discursive spaces that mirror real life, yet stand in opposition to it. I propose to look at heterotopia through the lens of youth citizenship that is presented in different forms of self-identification in the discursive practices of the selected youth organisations. The article analyses the discursive language of six Ukrainian youth organisations that appear as spaces of their own, drawing on Foucault’s notion of heterotopia. The task of the article is to examine how these contemporary heterotopias are identified through the language and specific keywords used by their members and how this language defines the space in which their members function, as well as gain insight into the categories of We and They, including their role in self-identification and the delineation of boundaries between the different heterotopias. In this article, I argue that the contexts of the use of the categories We and They with which young people name themselves and separate themselves from non-members of the organisation, have a strong influence on their citizen participation strategies. The empirical results show that organizations position and locate themselves as political and community acting-spaces—heterotopias of citizenship—that have responsibilities and act in accordance with their mission. Although the forms of citizen participation they use vary, their ultimate mission seems to be the same, and may be related to a sense of insecurity caused by a political threat from the Other.
Experimental study of concrete mixes using crushed and uncrushed coarse aggregates by adopting ACI and DoE methods
Authors: Hassaballa A. E. 
Published: January 2024

AbstractThe main objective of this research is to investigate experimentally the effect of crushed and uncrushed coarse aggregate on the properties of hardened concrete (compressive strength) by adopting the American Concrete Institute (ACI) and the British Department of Environment (DoE) methods. Concrete mixes were designed, concrete cubes and cylinders were prepared and casted by using DoE and ACI respectively. DoE concrete design method considers both types of aggregates; crushed and uncrushed, while the ACI method does not take into account the effect of uncrushed coarse aggregate in design provisions. Then compressive strength tests of concrete samples were determined at ages of 7 and 28 days full curing period. The results obtained show that ACI gave higher values of compressive strength than that obtained by DoE for M30 and M40 except M25, which resulted in lower values than that obtained by DoE for crushed coarse aggregates. The 7-day compressive strength represents 75% of the 28-day compressive strength for ACI method, whereas in DoE reaching up to 73% and 77% for crushed and uncrushed coarse aggregate, respectively.