bluuebunny/crossref_metadata_2025_split huggingface dataset:
Presidential Address 2023: The Beauty of Uncertainty: The Rise of Insurance Contracts and Markets in Medieval Europe
Authors: Botticini Maristella , Buri Pietro , Marinacci Massimo 
Published: October 2023

Abstract
Maritime insurance developed in medieval Europe is the ancestor of all forms of insurance that appeared subsequently. We address the question of why modern insurance was first invented in medieval Europe, and neither earlier nor elsewhere. Drawing from insights from the literature on uncertainty aversion, we show that medieval merchants had to bear more frequently natural risks (they traveled longer distances) and new human risks with unknown probabilities (they faced unpredictable attacks by corsairs due to increased political fragmentation and commercial competition in Europe). The increased demand for protection in medieval seaborne trade met the supply of protection by a small group of wealthy merchants with a broad information network who could pool risks and profit from selling protection through a novel business device: the insurance contract. A new market—the market for insurance—was then born. Next, analyzing more than 7,000 insurance contracts redacted by notaries and about 100 court proceedings housed in the archives of Barcelona, Florence, Genoa, Palermo, Prato, and Venice, we study the main features of medieval trade, the type of risks faced by merchants, and the characteristics of insurance contracts and markets from 1340 to 1500.The empirical analysis delivers two main findings. First, risks related to human activities (e.g., attacks by corsairs) seem to have had a relatively greater impact on insurance premia compared to natural risks (proxied by seasonal risks). Second, distance mattered but the route seems to have had a greater impact on insurance premia. Specific routes (e.g., in the Tyrrhenian and the western Mediterranean) were more plagued by human risks, which were harder to avoid for the majority of merchants who did not have a broad information network compared to the few wealthy merchants, who became the key players in selling insurance in the early stages of the development of insurance markets.
The Zoom city: working from home, urban productivity and land use
Authors: Kyriakopoulou Efthymia , Picard Pierre M 
Published: October 2023

Abstract
This article investigates the impact of working from home (WFH) on the emergence and structure of monocentric cities. In the long run, WFH raises urban productivity only in sufficiently large cities. Business land rents fall while residential land rents decrease near the business district. Workers have incentives to adopt inefficiently high WFH schemes. In the short run, WFH yields mixed benefits for commuters and firms, which corroborates the low WFH adoption before the pandemic. Advances in digital technology increase the welfare benefits of WFH. Calibration exercises on European capital cities shed light on the quantitative impact of WFH.
Collecting antiquities in wartime
Authors: Donaldson James , Asmussen Brit , McWilliam Janette , Parkhill David 
Published: October 2023

Abstract
During the First World War (1914–1918), many service personnel collected souvenirs from the countries in which they served, but the collection of antiquities by service personnel remains a neglected area of research. Between 2019 and 2021, the R. D. Milns Antiquities Museum at the University of Queensland and the Queensland Museum collaborated in a research partnership to learn more about the antiquities collecting activities of First World War personnel from Queensland, Australia. In addition to reporting on the preliminary results of that pilot study, this paper also begins to address the question of why antiquities appealed to service personnel. Most artefacts in this study are from the private collections donated to the Queensland Museum and from three privately owned collections. Artefacts are mostly small ‘curios’ such as scarabs, figurines, coins and fragments of monuments collected in various theatres of the war.
The hybrid work of public sector data scientists
Authors: Lorenz Lukas 
Published: October 2023

Abstract
As algorithms play an increasingly important role in public organizations, we see a rise in the number of public sector data scientists. Even though the relevance and risks of algorithms in the public sector are broadly discussed, our current academic knowledge of public sector data scientists and their work is limited. To develop an understanding of their work practices, data scientists have been studied in two Dutch government organizations. In a core period of 5 months per organization, I conducted in-depth qualitative research into the work of the data scientists, their role in the organization, and their relationship with other actors at two regulatory agencies in the Netherlands. The analysis shows that data scientists integrate Silicon Valley and engineering, domain, as well as political–administrative logics in their work practices. Thus, the work of the data scientists is hybrid. However, even though the organizational contexts are very similar, hybrid work takes very different forms both across organizations and over time. This dynamic hybridity is linked to different algorithmization processes and outcomes in the two organizations. The results suggest that hybridity in public sector data scientists’ work should be adapted to organizational and technological aspects of transformation processes and aspired outcomes.
Ultrasound-mediated delivery of Pik3cb shRNA using magnetic nanoparticles for the treatment of in-stent restenosis in a rat balloon-injured model
Authors: Wang Yuhao , Li Miao , Sheng Zongxiang , Ran Hong , Dong Jing , Fang Lingling , Zhang Pingyang 
Published: October 2023

Abstract
The aim of the present work was to examine the effect of polyethylene glycol (PEG)-coated superparamagnetic iron oxide (SPIO) nanoparticles carrying Pik3cb short hairpin RNA (shRNA) in the prevention of restenosis with the aid of ultrasound and a magnetic field. SPIO is a type of contrast agent used in medical imaging to enhance the visibility of specific tissues or organs. It consists of tiny iron oxide nanoparticles that can be targeted to specific areas of interest in the body. PEG-coated SPIO nanoparticles carrying Pik3cb shRNA (SPIO-shPik3cb) were prepared, and the particle size and zeta potential of PEG-coated SPIO nanoparticles with and without Pik3cb shRNA were examined. After a right common artery balloon-injured rat model was established, the rats were randomly divided into four groups, and the injured arteries were transfected with SPIO-shPik3cb, saline, SPIO-shcontrol and naked shRNA Pik3cb. During the treatment, each group was placed under a magnetic field and was transfected with the aid of ultrasound. Rats were sacrificed, and the tissue was harvested for analysis after 14 days. The results suggested that the mean particle size and zeta potential of SPIO-shPik3cbs were 151.45 ± 11 nm and 10 mV, respectively. SPIO-shPik3cb showed higher transfection efficiency and significantly inhibited the intimal thickening compared with naked Pik3cb shRNA in vascular smooth muscle cells (VSMCs) (*P &lt; 0.05). Moreover, SPIO-shPik3cb could also significantly downregulate the expression of pAkt protein compared with naked Pik3cb shRNA. According to the results, SPIO-shPik3cb can remarkably inhibit the intimal thickening under a combination of magnetic field exposure and ultrasound.
Effect of Liraglutide on Osteoporosis in a Rat Model of Type 2 Diabetes Mellitus: A Histological, Immunohistochemical, and Biochemical Study
Authors: Fathy Maha Abdelhamid , Anbaig Amal , Aljafil Raja , El-Sayed Sherein F , Abdelnour Hanim Magdy , Ahmed Mona Mostafa , Abdelghany Eman M A , Alnasser Sulaiman Mohammed , Hassan Shaimaa Mohamed Abdelfattah , Shalaby Amany Mohamed 
Published: October 2023

Abstract
Diabetic osteoporosis (DOP) is a diabetic complication associated with a significant disability rate. Liraglutide, a glucagon-like peptide-1 receptor agonist, is a promising and innovative drug for type 2 diabetes mellitus (T2DM), with potential therapeutic implications for bone disorders. This investigation examined the impact of liraglutide on osteoporosis in rats with T2DM and studied the influence of vitamin D receptor Bsm1 polymorphism on liraglutide-induced outcomes. Thirty rats were divided into control, T2DM induced by a combination of a high-fat diet and 25 mg/kg streptozotocin, and T2DM-liraglutide (T2DM treated with 0.4 mg/kg/day liraglutide) groups. After 8 weeks of liraglutide treatment, femurs and blood samples were obtained from all rats for subsequent investigations. Diabetes induced a remarkable rise in the serum levels of receptor activator of nuclear factor kappa B ligand (RANKL) and C-telopeptide of type I collagen (CTX-1) associated with a remarkable decline in osteocalcin and osteoprotegerin (OPG). Impaired bone architecture was also demonstrated by light and scanning electron microscopic study. The immune expression of OPG was down-regulated, while RANKL was up-regulated. Interestingly, the administration of liraglutide ameliorated the previous changes induced by diabetes mellitus. In conclusion, liraglutide can prevent DOP, mostly due to liraglutide's ability to increase bone growth, while inhibiting bone resorption.
Evaluating Stage Motion for Automated Electron Microscopy
Authors: Fiedler Kevin R , Olszta Matthew J , Yano Kayla H , Doty Christina , Hopkins Derek , Akers Sarah , Spurgeon Steven R 
Published: October 2023

Abstract
Precise control is an essential and elusive quality of emerging self-driving transmission electron microscopes (TEMs). It is widely understood these instruments must be capable of performing rapid, high-volume, and arbitrary movements for practical self-driving operation. However, stage movements are difficult to automate at scale, owing to mechanical instability, hysteresis, and thermal drift. Such difficulties pose major barriers to artificial intelligence-directed microscope designs that require repeatable, precise movements. To guide design of emerging instruments, it is necessary to understand the behavior of existing mechanisms to identify rate limiting steps for full autonomy. Here, we describe a general framework to evaluate stage motion in any TEM. We define metrics to evaluate stage degrees of freedom, propose solutions to improve performance, and comment on fundamental limits to automated experimentation using present hardware.
The orbital period of the recurrent nova V2487 Oph revealed
Authors: Rodríguez-Gil Pablo , Corral-Santana Jesús M , Elías-Rosa N , Gänsicke Boris T , Hernanz Margarita , Sala Gloria 
Published: October 2023

ABSTRACT
We present the first reliable determination of the orbital period of the recurrent nova V2487 Oph (Nova Oph 1998). We derived a value of 0.753 ± 0.016 d (18.1 ± 0.4 h) from the radial velocity curve of the intense He ii λ4686 emission line as detected in time-series X-shooter spectra. The orbital period is significantly shorter than earlier claims, but it makes V2487 Oph one of the longest period cataclysmic variables known. The spectrum of V2487 Oph is prolific in broad Balmer absorptions that resemble a white dwarf spectrum. However, we show that they come from the accretion disc viewed at low inclination. Although highly speculative, the analysis of the radial velocity curves provides a binary mass ratio q ≈ 0.16 and a donor star mass M2 ≈ 0.21 M⊙, assuming the reported white dwarf mass M1 = 1.35 M⊙. A subgiant M-type star is tentatively suggested as the donor star. We were lucky to inadvertently take some of the spectra when V2487 Oph was in a flare state. During the flare, we detected high-velocity emission in the Balmer and He ii λ4686 lines exceeding −2000 km s−1 at close to orbital phase 0.4. Receding emission up to 1200 km s−1 at about phase 0.3 is also observed. The similarities with the magnetic cataclysmic variables may point to magnetic accretion on to the white dwarf during the repeating flares.
QUIJOTE Scientific Results – XVII. Studying the anomalous microwave emission in the Andromeda Galaxy with QUIJOTE-MFI
Authors: Fernández-Torreiro M , Génova-Santos R T , Rubiño-Martín J A , López-Caraballo C H , Peel M W , Arce-Tord C , Rebolo R , Artal E , Ashdown M , Barreiro R B , Casas F J , de la Hoz E , Guidi F , Herranz D , Hoyland R , Lasenby A , Martínez-Gonzalez E , Piccirillo L , Poidevin F , Ruiz-Granados B , Tramonte D , Vansyngel F , Vielva P , Watson R A 
Published: October 2023

ABSTRACT
The Andromeda Galaxy (M31) is the Local Group galaxy that is most similar to the Milky Way (MW). The similarities between the two galaxies make M31 useful for studying integrated properties common to spiral galaxies. We use the data from the recent QUIJOTE-MFI Wide Survey, together with new raster observations focused on M31, to study its integrated emission. The addition of raster data improves the sensitivity of QUIJOTE-MFI maps by almost a factor 3. Our main interest is to confirm if anomalous microwave emission (AME) is present in M31, as previous studies have suggested. To do so, we built the integrated spectral energy distribution of M31 between 0.408 and 3000 GHz. We then performed a component separation analysis taking into account synchrotron, free–free, AME, and thermal dust components. AME in M31 is modelled as a log-normal distribution with maximum amplitude, AAME, equal to 1.03 ± 0.32 Jy. It peaks at ${\nu _{\rm AME}}=17.2\pm 3.2{\rm \, GHz}{}$ with a width of WAME = 0.58 ± 0.16. Both the Akaike and Bayesian information criteria find the model without AME to be less than 1 per cent as probable as the one taking AME into consideration. We find that the AME emissivity per 100 $\mu$m intensity in M31 is ${\epsilon _{\rm AME}^{\rm 28.4\, GHz}}=9.6\pm 3.1\,\mu$K MJy−1 sr, similar to that of the MW. We also provide the first upper limits for the AME polarization fraction in an extragalactic object. M31 remains the only galaxy where an AME measurement has been made of its integrated spectrum.
DNA Damage Atlas: an atlas of DNA damage and repair
Authors: Liang Yu , Yuan Qingqing , Zheng Qijie , Mei Zilv , Song Yawei , Yan Huan , Yang Jiajie , Wu Shuheng , Yuan Jiao , Wu Wei 
Published: October 2023

Abstract
DNA damage and its improper repair are the major source of genomic alterations responsible for many human diseases, particularly cancer. To aid researchers in understanding the underlying mechanisms of genome instability, a number of genome-wide profiling approaches have been developed to monitor DNA damage and repair events. The rapid accumulation of published datasets underscores the critical necessity of a comprehensive database to curate sequencing data on DNA damage and repair intermediates. Here, we present DNA Damage Atlas (DDA, http://www.bioinformaticspa.com/DDA/), the first large-scale repository of DNA damage and repair information. Currently, DDA comprises 6,030 samples from 262 datasets by 59 technologies, covering 16 species, 10 types of damage and 135 treatments. Data collected in DDA was processed through a standardized workflow, including quality checks, hotspots identification and a series of feature characterization for the hotspots. Notably, DDA encompasses analyses of highly repetitive regions, ribosomal DNA and telomere. DDA offers a user-friendly interface that facilitates browsing, searching, genome browser visualization, hotspots comparison and data downloading, enabling convenient and thorough exploration for datasets of interest. In summary, DDA will stand as a valuable resource for research in genome instability and its association with diseases.
Migration, technology diffusion, and growth
Authors: Ikhenaode Bright Isaac , Parello Carmelo Pierpaolo 
Published: October 2023

Abstract
This article proposes a two-country AK model of growth with cross-country knowledge diffusion and endogenous migration to study the relationship between migration, income inequality, and economic growth. In contrast with mainstream AK literature, the article shows that introducing knowledge diffusion from rich to poor countries makes AK models predict conditional convergence, but also that migration tends to cool the catching-up process of poorer economies. When testing the robustness of the policy implications of the AK literature in the presence of migration, we find that subsidizing capital accumulation in frontier countries stimulates migration and worldwide growth, but also that it increases cross-country inequalities in terms of both income and technology. On the contrary, subsidizing capital accumulation in non-frontier countries reduces migration and mitigates inequalities worldwide, but has no effects on the long-run pace of economic growth of the two countries.
Cardiac Abnormalities in Patients With Severe Fever With Thrombocytopenia Syndrome: A Systematic Review
Authors: Liu Qiaoling , Yang Mingming , Shen Shichun , Gong Chen , Lan Zuyong 
Published: October 2023

Abstract
Since the identification of severe fever with thrombocytopenia syndrome virus (SFTSV) in 2010, there has been an increase in reported cases in China and other Asian countries. Cardiac abnormalities are highly prevalent in SFTS patients. We searched 5 Chinese and international databases for published SFTS articles and extracted patient characteristics, cardiac complications, electrocardiography findings, and imaging findings. Twenty-seven studies were identified, covering 1938 patients and 621 cardiac abnormalities. Arrhythmia was the most prevalent, reported in 24 studies and 525 cases, with a prevalence of 27.09%. The 2 major types of arrhythmias were bradycardia and atrial fibrillation. Heart failure was the second most prevalent abnormality, with 77 cases. Changes in the ST segment and T wave were the most common. Valve regurgitation, reduced ejection fraction, and pericardial effusion were also documented. We recommend that physicians pay close attention to newly onset arrhythmia and structural heart disease in SFTS patients.
Histoplasma Seropositivity in TB Patients in The Gambia: Evidence to Drive Research on a High-Priority Fungal Pathogen
Authors: Cornell Tessa R , Jobe Dawda , Donkor Simon , Wootton Daniel G , Pinchbeck Gina , Sutherland Jayne S , Scantlebury Claire Elizabeth 
Published: October 2023

Abstract

Background
Inclusion of Histoplasma in the World Health Organization's first Fungal Priority Pathogens List under “high-priority” fungal species highlights the need for robust surveillance of Histoplasma spp. in endemic and underrepresented regions. Despite increasing reports of histoplasmosis in Africa, data on the burden of this fungal disease are sparse in The Gambia. This baseline study examined the human seroprevalence of anti-Histoplasma antibody in a TB patient group in The Gambia, explored associations between seropositivity and demographic and clinical variables, and proposes future research directions.

Methods
Biobanked plasma samples were selected from active TB cases with variable HIV infection status. Latex agglutination tests were performed on samples from 52 study participants to detect the presence of anti-Histoplasma antibodies. Potential risk factors for Histoplasma exposure were explored using logistic regression analysis.

Results
The sample seroprevalence of anti-Histoplasma antibody was 28.8% (n = 15/52; 95% CI, 17.1%–43.1%). Multivariable logistic regression analysis identified a statistically significant association between Histoplasma seropositivity and age (odds ratio, 0.91; 95% CI, 0.84–0.98; P = .008).

Conclusions
This baseline study provides evidence of Histoplasma seropositivity in TB patients in The Gambia and explores risk factors for exposure. The small sample size and use of the LAT in TB and HIV-positive patient groups are significant study limitations. Future research directions are proposed to ascertain the burden of Histoplasma in general and patient populations and explore the context-specific risk factors for exposure and infection in The Gambia.
Social media messaging by climate action NGOs: a case study of the 2019–2020 Australian Black Summer bushfires
Authors: Ettinger Joshua , Sanford Mary , Walton Peter , Holmes David , Painter James 
Published: October 2023

Abstract
Researchers are increasingly examining discourses associated with climate change and extreme weather events across different communication channels. However, further research is needed to examine how environmental non-governmental organizations (NGOs) frame extreme weather events and their relationship to climate change on social media platforms. This is an important topic as these groups play a significant role communicating science and driving environmental action. Here, we examine how Australian climate action NGOs framed the relationship of the 2019–2020 Black Summer bushfires to climate change on Twitter/X. Analyzing 2,077 bushfire-related tweets from a sample of 102 climate group accounts through manual content analysis, we found that these groups frequently linked bushfires with climate change, representing 59% of their bushfire-related tweets during the period of the fires. Forty-two percent of tweets mentioned climate change without describing how it relates to bushfires; 16% described specifically how climate change influences the frequency and intensity of bushfires; and only 1% suggested inaccurately that climate change causes bushfires to occur. Fifteen percent of tweets discussed risk factors beyond climate change that influence bushfire impacts, such as firefighting, emergency responses, hazard reduction, and community vulnerabilities. Only seven accounts mentioned an extreme event attribution study of the Black Summer fires. Based on these findings, we discuss opportunities and challenges of climate science communication in the extreme weather context, and describe promising directions for future research.
Disruption ofp-coumaroyl-CoA:monolignol transferases in rice drastically alters lignin composition
Authors: Lam Lydia Pui Ying , Tobimatsu Yuki , Suzuki Shiro , Tanaka Takuto , Yamamoto Senri , Takeda-Kimura Yuri , Osakabe Yuriko , Osakabe Keishi , Ralph John , Bartley Laura E , Umezawa Toshiaki 
Published: October 2023

AbstractGrasses are abundant feedstocks that can supply lignocellulosic biomass for production of cell-wall-derived chemicals. In grass cell walls, lignin is acylated with p-coumarate. These p-coumarate decorations arise from the incorporation of monolignol p-coumarate conjugates during lignification. A previous biochemical study identified a rice (Oryza sativa) BAHD acyltransferase (AT) with p-coumaroyl-CoA:monolignol transferase (PMT) activity in vitro. In this study, we determined that that enzyme, which we name OsPMT1 (also known as OsAT4), and the closely related OsPMT2 (OsAT3) harbor similar catalytic activity toward monolignols. We generated rice mutants deficient in either or both OsPMT1 and OsPMT2 by CRISPR/Cas9-mediated mutagenesis and subjected the mutants’ cell walls to analysis using chemical and nuclear magnetic resonance methods. Our results demonstrated that OsPMT1 and OsPMT2 both function in lignin p-coumaroylation in the major vegetative tissues of rice. Notably, lignin-bound p-coumarate units were undetectable in the ospmt1 ospmt2-2 double-knockout mutant. Further, in-depth structural analysis of purified lignins from the ospmt1 ospmt2-2 mutant compared with control lignins from wild-type rice revealed stark changes in polymer structures, including alterations in syringyl/guaiacyl aromatic unit ratios and inter-monomeric linkage patterns, and increased molecular weights. Our results provide insights into lignin polymerization in grasses that will be useful for the optimization of bioengineering approaches for the effective use of biomass in biorefineries.