bluuebunny/crossref_metadata_2025_split huggingface dataset:
Association of extreme heat events with sleep and cardiovascular health: A scoping review
Authors: Ashe Nathan , Wozniak Sarah , Conner Malcom , Ahmed Rayan , Demetres Michelle R , Makarem Nour , Tehranifar Parissa , Nandakumar Rajalakshmi , Ghosh Arnab 
Published: December 2023

Abstract

BACKGROUND:
Extreme heat events (EHEs), driven by anthropogenic climate change, exacerbate the risk of cardiovascular disease (CVD), although the underlying mechanisms are unclear. Disturbances in sleep health, caused by excessive heat, may be one way EHEs increase the risk of incident or recurrent CVD. Our objective was to systematically review the empirical peer-reviewed literature on the relationship between EHEs, sleep health, and cardiovascular measures and outcomes, and narratively describe methodologies, evidence, and gaps in this area.
METHODS:
A comprehensive literature search was performed in the following databases from inception – June 2023: Ovid MEDLINE, Ovid EMBASE, CINAHL, Web of Science and The Cochrane Library. Studies retrieved were then screened for eligibility against predefined inclusion/exclusion criteria.
RESULTS:
Of the 2035 records screened, three studies met the inclusion criteria. Cardiovascular (CV) measures described included blood pressure (BP), heart rate (HR), and HR variability (no CVD outcomes were described) and objective and subjective measurements of sleep health outcomes included sleep duration, calmness, ease of falling asleep, ease of awakening, freshness after awakening, and sleep satisfaction. Two studies were controlled trials, and one was a cohort study. During EHEs, individuals slept for shorter periods of time and less efficiently, with greater degrees of HR variability in two of the three studies lasting at most 1–2 days; BP (both systolic and diastolic) significantly decreased during EHEs in two of the studies. No formal assessment of a mediating relationship between EHE exposure, sleep outcomes, and the CV measures was undertaken.
CONCLUSIONS:
There is a paucity of data that examines the link between CVD, sleep, and extreme heat as a possible mechanism of elevated CVD risk during EHEs, despite a strong physiological rationale. Further research is needed to empirically test this relationship rigorously as EHEs become more frequent and their deleterious impacts of health increase.
Geo-Demographic and Socioeconomic Determinants of Diagnosed Hypertension among Urban Dwellers in Ibadan, Nigeria: A Community-based Study
Authors: Owolabi Mayowa , Taiwo Olalekan , Akinyemi Joshua , Adebayo Ayodeji , Popoola Oluwafemi , Akinyemi Rufus , Akpa Onoja , Olowoyo Paul , Okekunle Akinkunmi , Uvere Ezinne , Nwimo Chukwuemeka , Ajala Omotolani , Adebajo Olayinka , Ayodele Adewale , Ayodeji Salami , Arulogun Oyedunni , Olaniyan Olanrewaju , Walker Richard , Jenkins Carolyn , Ovbiagele Bruce 
Published: December 2023

Abstract
Background: The relationship between diagnosed high blood pressure (HBP) and proximity to health facilities and noise sources is poorly understood. We investigated the relationship between proximity to noise sources, sociodemographic and economic factors, and diagnosed HBP in Ibadan, Nigeria.
Methods: We investigated 13,531 adults from the African Rigorous Innovative Stroke Epidemiological Surveillance (ARISES) study in Ibadan. Using a Geographic Information System (GIS), the locations of healthcare facilities, pharmaceutical shops, bus stops, churches, and mosques were buffered at 100m intervals, and coordinates of persons diagnosed with HBP were overlaid on the buffered features. The number of persons with diagnosed HBP living at every 100m interval was estimated. Gender, occupation, marital status, educational status, type of housing, age, and income were used as predictor variables. Analysis was conducted using Spearman rank correlation and binary logistic regression at p<0.05.
Results: There was a significant inverse relationship between the number of persons diagnosed with HBP and distance from pharmaceutical shops (r=-0.818), churches (r=-0.818), mosques (r=-0.893) and major roads (r= -0.667). The odds of diagnosed HBP were higher among the unemployed (AOR=1.58, 95% CI: 1.11-2.24), currently married (AOR=1.45, CI: 1.11-1.89), and previously married (1.75, CI: 1.29-2.38). The odds of diagnosed HBP increased with educational level and age group.
Conclusion: Proximity to noise sources, being unemployed and educational level were associated with diagnosed HBP. Reduction in noise generation, transmission, and exposure could reduce the burden of hypertension in urban settings.
Ecological Impact of Artisanal Tin Mining in Butura, Plateau State, Nigeria
Authors: Zitta Wuyep Solomon , Samuel Dadiel , Simi Ogbole Alexandra , Musa Selzing Peter , Nentok Monday Seri 
Published: December 2023

Abstract

Artisanal tin mining is considered a necessary evil, but has the ability to boost the economy, reduce poverty, and create jobs and income. However, it is frequently unregulated, hence has a negative effect on the environment. Data were collected from mining sites for laboratory analysis and direct field observation. Random sampling technique was use to select four soil samples of 500 grams, two each for mined and unmined soils were collected within a depth of 0-15cm. These sampled soils were tested in the laboratory to determine their physio-chemical properties. Chi-square was used to evaluate the significant difference between soil from mined and unmined areas. Results showed that there is an increase in soil pH, EC, K, Na, Ca, Mg, EA, CEC, particles density, porosity and clay, and decrease in OC, OM, N, P, S, Silt, and sand of the soil properties. The findings revealed that mining activities caused severe ecological consequences on the environment which led to deforestation, soil erosion, loss of biodiversity and creation of abandoned mine pits and ponds that pose serious danger to humans. Many farmlands, grazing lands and forest reserve have been degraded as the result of artisanal mining, top soil has been removed which affect the fertility of the soil resulting in low crop yields. The chi-square analysis showed a significant relationship between artisanal tin mining and soil quality at 58% confident level. Therefore, this study recommends the use of best mining practices to safeguard the environment in the study area.
Spatial mapping of subcutaneous adipose tissue microenviounment in panniculitis: Unveiling novel immune signatures
Authors: Brüggen Marie-Charlotte , Ziadlou Reihane , Ameri Milad , Contassot Emmanuel , White Anna , Li Nick , Kolm Isabel , Kempf Werner , Traidl Stephan , Clemens Clara , Hafner Jürg , Akdis Cezmi , Maverakis Emanual 
Published: December 2023

Abstract
Panniculitis, characterized by inflammation of the subcutaneous adipose tissue, displays diverse clinical and dermatohistopathological phenotypes. However, the underlying pathomechanisms remain largely unknown, with limited studies pointing to a delayed-type III/IV hypersensitivity reaction. In the present study, we aimed to gain new insights into the pathogenesis of the two most common panniculitis subtypes, erythema nodosum (EN) and erythema induratum (EI), by exploring their cellular and molecular immune patterns. We analyzed deep lesional skin biopsies from EN and EI patients (n=16 per group) and healthy controls (n=6) using imaging mass cytometry (IMC) to map the leukocytic infiltrate. The IMC analysis revealed distinct cellular profiles for EN and EI. In both conditions, macrophages were the predominant immune cell type, exhibiting a shift towards an M1 phenotype compared to healthy controls. In EI, the M1 macrophages were particularly prominent and were noted to cluster with activated CD8+ T cells. Conversely, EN showed fewer inflammatory features and a larger B cell population. These cellular changes were supported by an overall strong type 1 immune signature on the mRNA level in both EN and EI. This was evidenced by the upregulation of NLR-, NFkB-, and inflammasome-signaling-pathway genes compared to healthy controls. The type 1 signature was more pronounced in EI than in EN. These findings challenge the current understanding of panniculitis. They point towards a key role of M1 macrophages in mediating both innate and adaptive immune responses in panniculitis.
Electrochemically Activated Histidine-tagged Flavoenzyme-mediated Biopseudocapacitor
Authors: Sung Suhwan , Jin Joon-Hyung 
Published: December 2023

Abstract
Polypeptides or enzyme proteins have specific functions depending on their unique three-dimensional structures. Active-site histidine or histidine tags in an enzyme protein can be used to fix an electrochemically active species to the enzyme and can be further used as an electroactive material for the electrode substrate of a faradaic supercapacitor, which is an energy storage device with high power density. Here, we introduce an enzyme-linked electric double-layer capacitor and a pseudocapacitor prepared by cyclovoltametrically intercalating histidine moieties of the linked enzymes with ferricyanide ions. Indium tin oxide (ITO) was employed as the electrode substrate for immobilization of histidine-tagged methyl tryptophan oxidase (HMTO). After attaching HMTO via amino-glutaraldehyde cross-linking chemistry, the resulting HMTO-ITO electrodes were further activated with ferricyanide. The approximate amount of HMTO immobilized on an ITO substrate of area 1.13 cm2 was 3.3 ± 0.46 µC, equivalent to 11.4 pmole (0.49 µg) of HMTO. The specific capacity of the biopseudocapacitor determined using cyclic voltammetry was 6.19 C g− 1 at a scan rate of 10 mV s− 1.
Association of novel DNAH11 and DNAH 5 variants with oligoasthenoteratozoospermia lead to male infertility
Authors: Tang Dongdong , Guo Senzhao , Chen Yuge , Yu Hui , Gu Meng , Geng Hao , Fang Jiajun , Wu Baoyan , Ruan Lewen , Li Kuokuo , Xu Chuan , Gao Yang , Tan Qing , Duan Zongliu , Wu Huan , Hua Rong , Guo Rui , Wei Zhaolian , Zhou Ping , Xu Yuping , Cao Yunxia , He Xiaojin , Sha Yanwei , Lv Mingrong 
Published: December 2023

Abstract
Background
Bi-allelic variants in DNAH11 and DNAH5 have been identified as causative factors in Primary Ciliary Dyskinesia, leading to abnormal respiratory cilia. Nonetheless, the specific impact of these variants on sperm flagellar and their involvement in male infertility remain elusive.
Methods
A collaborative effort involving two Chinese reproductive centers conducted a study with 975 unrelated infertile men. Whole-exome sequencing was employed for variant screening, and Sanger sequencing confirmed the identified variants. Morphological and ultrastructural analyses of sperm were conducted using Scanning Electron Microscopy and Transmission Electron Microscopy. Western Blot Analysis and Immunofluorescence Analysis were utilized to assess protein levels and localization. ICSI was performed to evaluate its efficacy in achieving favorable pregnancy outcomes for individuals with DNAH11/DNAH5 variants.
Results
The study identified seven novel variants in the DNAH11 gene in four subjects and two novel variants in the DNAH5 gene in one individual with oligoasthenoteratozoospermia. These variants led to structural defects in sperm flagella, particularly affecting the outer dynein arms (ODAs) and adjacent structures. Two out of four individuals with DNAH11 variants achieved clinical pregnancies through ICSI. However, the patient carrying DNAH5 variants did not achieve a favorable pregnancy outcome.
Conclusions
The findings confirm the association between male infertility and bi-allelic deleterious variants in DNAH11/DNAH5, resulting in the aberrant assembly of sperm flagella and contributing to oligoasthenoteratozoospermia. Importantly, ICSI emerges as an effective intervention for overcoming reproductive challenges caused by DNAH11 gene variants.
Constipation and diarrhea's relationship with alcohol consumption in adult Americans: evidence from NHANES 2005-2010
Authors: Gong Zhuozhi , Li Teng , Du Yanyuan , Yan He , Xu Minhao , Lian Yue , Wei Wei , Liu Tao 
Published: December 2023

Abstract
Objective
The consumption of alcohol as a part of daily life influences our intestinal health, with both positive and negative effects. There is limited research on the constipation and diarrhea's relationship with alcohol. This study delves into the detailed relationship between fecal shape and alcohol consumption in American adults. Stool shape was categorized as constipation, normal, and diarrhea.
Methods
For this cross-sectional study, we selected a sample of 8829 adults aged 20 years and older from the 2005–2010 National Health and Nutrition Examination Survey. Definitions for constipation, diarrhea, and bowel health were established using the Bristol Scale. Chronic constipation encompassed types 1 and 2; types 6 and 7 were categorized as diarrhea; and types 3, 4, and 5 were deemed indicative of bowel health. To investigate the association between stool shape and alcohol consumption, we employed univariate logistic regression models, multivariate logistic regression models, and multilevel linear regression models.
Results
The population with constipation exhibited a significantly lower drinking frequency compared to those with diarrhea and the normal subjects. Furthermore, drinking frequency was negatively correlated with the risk of constipation in women. Drinking frequency served as a protective factor for women experiencing constipation, but this association was not observed in men with constipation. Among individuals who consumed more than 12 drinks per year, the normal group was notably overrepresented in the constipated group. Individuals who consumed more than 5 drinks per day for a period were more prone to experiencing diarrhea, and this trend was more pronounced in women than in men. Additionally, the average number of drinks consumed in the past 12 months was significantly associated with diarrhea in women.
Conclusion
In summary, this study demonstrates a significant association between stool shape and alcohol consumption. Healthcare professionals can contribute to the diagnosis and treatment of patients by considering their lifestyle, and patients can proactively adjust their lifestyle to alleviate constipation or diarrhea.
Kidney outcomes are altered by preconception weight modulation in rodent mothers with obesity
Authors: Rodrigo Natassia , Chen Hui , Pollock Carol A , Glastras Sarah J 
Published: December 2023

Abstract

Obesity increases the risk of chronic kidney disease in the mother. We have previously demonstrated the benefits of preconception maternal weight loss on fertility and pregnancy outcomes in a mouse model of maternal obesity. In this study, we aimed to determine if preconception weight loss, either by diet modification or the glucose-like peptide 1 agonist liraglutide, improves maternal kidney outcomes in late gestation. C57BL/6 female mice were fed either a high-fat-diet (HFD) or a standard chow (control) diet for 8 weeks. To induce pre-pregnancy weight loss, HFD-fed dams were either switched to a chow diet pre-pregnancy (4 weeks before mating, HFD-C) or administered liraglutide (0.3mg/kg subcutaneous, for 4weeks) whilst continuing on HFD (HFD-L). Liraglutide was discontinued one week prior to mating. HFD-V mice continued on HFD, with saline injections. Finally, a group of HFD-fed dams were ‘diet switched’ to a chow diet after conception (i.e., post-conception, HFD-PC). Maternal body weight and glucose tolerance were measured at two time points: prior to pregnancy and during late gestation followed by blood, urine and kidney collection. Serum creatinine, urinary creatinine and albumin, and kidney tissue gene expression and protein were measured. In the preconception period, the HFD-L and HFD-C mothers had lower urine albumin: creatinine ratios (UACR) and fatty acid synthase (FAS) protein expression (both P < 0.005 vs HFD-V). At late gestation, the kidneys of HFD-V and HFD-PC dams had increased gene expression of insulin receptor and FAS (both P < 0.05) and higher UACR compared to controls (P < 0.01). In the HFD-PC group, the kidneys showed increased mRNA and protein expression of metabolic and oxidative stress markers (FAS, 8-OHdG vs control, P < 0.05, P < 0.0001 respectively). The preconception intervention groups with liraglutide, or diet change showed reduced renal oxidative stress markers (protein expression of 8-OHdG, P < 0.05 vs HFD), mRNA and protein expression of FAS (P < 0.05 vs HFD), protein expression of fibrosis markers (collagen IV, fibronectin vs HFD, P < 0.05), and UACR (P < 0.05 vs HFD). Preconception weight loss benefits maternal kidney health during pregnancy, superior to diet intervention once pregnancy is established. This study suggests that pre-pregnancy weight reduction is necessary to optimise kidney outcomes in maternal obesity.
Biomarkers of inflammation and cardiovascular risk in people with chronic obstructive respiratory disease
Authors: ESCOBAR-MONTALVO JUAN MANUEL , RODRÍGUEZ-ARTALEJO FERNANDO , LABACA IÑAKI GALÁN 
Published: December 2023

Abstract
Background: Metabolic syndrome (MetS) is associated with increased frequency and severity of chronic obstructive respiratory diseases (CORD). Objectives: to examine the association of CORD with MetS, inflammatory and cardiovascular biomarkers, and its combined effect on health status and cardiovascular disease (CVD).
Methods: a cross-sectional study of 11602 adults of ≥18 years participants in the Study on Nutrition and Cardiovascular Risk in Spain (ENRICA) was conducted. Biomarkers were obtained using standardized laboratory techniques. CORD was defined as a diagnosis of chronic bronchitis and/or asthma, MetS was defined according to the criteria of the International Diabetes Federation, and CVD as a diagnosis of myocardial infarction, heart failure, or stroke. The associations were evaluated using linear and logistic regression models, adjusting for potential confounding variables.
Results: prevalence of MetS in subjects with and without CORD was 26.9% and 23% respectively. CORD was associated with a higher frequency of MetS in <65 years (odds ratio[OR]=1.38; 95%CI:1.07;1.77), higher levels of leptin (21.12%; 95%CI: 6.68;37.50) and fibrinogen (3.79%; 95%CI:0.19;7.52) in ≥65 years, and in whole population with higher prevalence of central obesity (OR=1.30; 95%CI:1.06;1.59) and elevated C-reactive protein levels (17.75%; 95%CI:2.67;35.04). People with CORD, with and without MetS, had a worse health status, and a higher risk of CVD when coexisting with MetS.
Conclusions: CORD was associated with alterations in inflammatory and cardiovascular biomarkers, higher frequency of MetS in <65 years, poorer health status, and higher risk of CVD when coexisted with MetS.
Predictors of Clinical Cure and off-treatment HBsAg Reversion in Patients with Chronic Hepatitis B receiving Peg-interferon-α-based Therapy
Authors: Liu Zhongwei , Liu Ming , Gong Hongmei , Li MaoShi , Wang Jing , Tan Zhaoxia , Wu Yi , Yang Yanlin , Deng Ying , Mao Qing 
Published: December 2023

Abstract
Background
Currently, pegylated interferon-α (Peg-IFN-α)-based antiviral therapy brings dawn to the clinical cure of chronic hepatitis B(CHB). Our aim was to investigate markers associated with clinical cure and off-treatment hepatitis B surface antigen (HBsAg) reversion in CHB receiving Peg-IFN-α-based therapy.
Methods
In total, 101 patients with hepatitis B e antigen-negative CHB who were treatment-naive or nucleotide analogs(NAs) treated patients were enrolled, then they were all received Peg-IFN-α-based therapy. Hepatitis B core-related antigen (HBcrAg), HBsAg and hepatitis B surface antibody (HBsAb) levels were examined dynamically and used to investigate the predictive value for HBsAg clearance and off-treatment reversion.
Results
Out of 101 patients, 41(40.59%) individuals achieved HBsAg clearance at the end of treatment (EOT). High baseline HBsAg (2.32 log10 IU/mL) combined with HBcrAg (3.90 log10 U/mL) was strongly associated with the HBsAg clearance (AUC = 0.714, P<0.001). The HBcrAg and HBsAg decline from baseline to week 12 showed good ability to predict HBsAg clearance (AUC = 0.807, P<0.001), while the HBsAg decline from week 12 to 24 were associated with HBsAg clearance (AUC = 0.745, P<0.001). A combination of HBcrAg < 3.80 log10 U/mL and HBsAb ≥ 51.50 IU/L at EOT had a negative predictive value of 85.71% for off-treatment HBsAg reversion (AUC = 0.840, P < 0.001).
Conclusions
HBcrAg and HBsAg can be used to predict clinical cure, while the HBcrAg and HBsAb were closely related to the off-treatment HBsAg reversion in patients with CHB receiving Peg-IFN-α-based therapy.
Disaster management of the coastal Cameroon Business City using a combined GIS-remote sensing and multicriteria decision-making approach
Authors: Aretouyap Zakari , Ghomsi Franck Eitel , Kana Janvier Domra , Tchato Sandra Celeste , Perilli Nicola , Nouck Philippe Njandjock 
Published: December 2023

Abstract
The Cameroon Business City (CBC), Douala, is the Cameroon’s city which has the highest urbanisation and demographic growth rate. It is located on the Atlantic banks. Its geographic features are major indicators of various potential disasters, with natural (geological, hydrological, oceanographic, meteorological, biological) and/or anthropogenic (mainly industrial) drivers to be adequately managed. Disaster management is a tedious and complex process involving an important number of criteria to be considered and assessed. It includes a wide range of tasks such as forecasting, monitoring, evacuation, relief, search and rescue, rehabilitation and reconstruction, that can be grouped into three phases: pre-disaster, during disaster and post-disaster operations. Rather than preparing disaster response, this paper investigates the risk reduction by analysing the vulnerability of the CBC to disasters. It is a matter of predicting disasters by safeguarding timely preparedness on concerned institutions, government agencies, non-government organisations (NGOs) and citizens. The objective of this paper is to combine geographic information system (GIS), remote sensing (RS) and analytical hierarchy process (AHP) for disaster prediction in the CBC. A set of maps (with key role in disaster assessment) are derived and processed from satellite data. In addition to other thematic maps dealing with ecological, environmental, biophysical, and socioeconomic features, the aforementioned maps are processed as layers in a GIS environment using AHP to demarcate and classify the CBC by level of landslide risk and a gathering zone in case of a tsunami. Policy perspectives are also formulated to the attention of the municipal authorities, NGOs, planners and civil engineers.