bluuebunny/crossref_metadata_2025_split huggingface dataset:
Wall‐mounted folding chairs to promote resident physician sitting at the hospital bedside
Authors: Golden Blair P. , Tackett Sean , Kobayashi Kimiyoshi , Nelson Terry S. , Agrawal Alison M. , Zhang Jerry , Jackson Nicole A. , Mills Geron , Lorigiano Ting‐Jia , Hirpa Meron , Lin Jessica S. , Johnson Trent , Sajja Aparna , Disney Sarah , Huang Shanshan , Nayak Juhi , Lautzenheiser Matthew , Berry Stephen A. 
Published: January 2024

AbstractBackgroundSitting at the bedside may improve patient‐clinician communication; however, many clinicians do not regularly sit during inpatient encounters.ObjectiveTo determine the impact of adding wall‐mounted folding chairs inside patient rooms, beyond any impact from a resident education campaign, on the patient‐reported frequency of sitting at the bedside by internal medicine resident physicians.Design, Setting, and ParticipantsProspective, controlled pre‐post trial between 2019 and 2022 (data collection paused 2020–2021 due to COVID‐19) at an academic hospital in Baltimore, Maryland. Folding chairs were installed in two of four internal medicine units and educational activities were delivered equally across all units.Main Outcome and MeasuresPatient‐reported frequency of sitting at bedside, assessed as means on Likert‐type items with 1 being “never” and 5 being “every single time.” We also examined the frequency of other patient‐reported communication behaviors.ResultsTwo hundred fifty six and 206 patients enrolled in the pre and post‐intervention periods, respectively. The mean frequency of patient‐reported sitting by resident physicians increased from 1.8 (SD 1.2) to 2.3 (1.2) on education‐only units (absolute difference 0.48 [95% CI: 0.21–0.75]) and from 2.0 (1.3) to 3.2 (1.4) on units receiving chairs (1.16, [0.87–1.45]). Comparing differences between groups using ordered logistic regression adjusting for clustering within residents, units with added chairs had greater increases in sitting (odds ratio 2.05 [1.10–3.82]), spending enough time at the bedside (2.43 [1.32–4.49]), and checking for understanding (3.04 [1.44–6.39]). Improvements in sitting and other behaviors were sustained on both types of units.ConclusionsAdding wall‐mounted folding chairs may help promote effective patient‐clinician communication.
Association between inpatient team continuity and clerkship student academic performance
Authors: Sawicki Jonathan G. , Sriram Karishma , Hansen Ivy , Good Brian 
Published: January 2024

AbstractObjectiveTo determine the association between inpatient team continuity, defined as the maximum number of days the same student, resident, and attending worked together on the inpatient wards, and the academic performance of students in a pediatric block clerkship.MethodsWe retrospectively identified students who rotated in the pediatric clerkship at a single institution from 2020 to 2022. We used multiple linear regression models to adjust for multiple confounders and used a one‐way analysis of variance to compare adjusted outcomes across quartiles of inpatient team continuity.ResultsA total of 227 students were included in the analysis. Students' preceptor ratings increased by 0.04 on a scale of 0–4 (95% confidence interval [CI] 0.01–0.06; p = .001), and their final pediatric grade increased by 0.02 on a scale of 0–4 (95% CI 0.01–0.02; p < .001) with each 1‐day increase in inpatient team continuity. There was no statistically significant association between team continuity and shelf exam scores or observed structured clinical examination scores. Preceptor ratings and final clerkship grades increased across quartiles of team continuity, with the greatest increase being between the second, 6–7 days of continuity, and third, 8–10 days of continuity, quartiles.ConclusionsIncreased inpatient team continuity is associated with students receiving higher preceptor ratings and achieving a higher final pediatric clerkship grade. While the mechanisms driving these associations remain unknown, the results add to the literature base supporting the importance of preceptor continuity in undergraduate medical education.
Development and evaluation of best practice advisory alert for patient eligibility in a hospital‐at‐home program: A multicenter retrospective study
Authors: Maniaci Michael J. , Torres‐Guzman Ricardo A. , Avila Francisco R. , Maita Karla , Garcia John P. , Forte Antonio J. , Rutledge Rachel , Dugani Sagar B. , Campbell Shannon M. , Pritchard Ingrid J. , Paulson Margaret R. 
Published: January 2024

AbstractBackgroundHospital‐at‐home (HaH) is a growing model of care that has been shown to improve patient outcomes, satisfaction, and cost‐effectiveness. However, selecting appropriate patients for HaH is challenging, often requiring burdensome manual screening by clinicians. To facilitate HaH enrollment, electronic health record (EHR) tools such as best practice advisories (BPAs) can be used to alert providers of potential HaH candidates.ObjectiveTo describe the development and implementation of a BPA for identifying HaH eligible patients in Mayo Clinic's Advanced Care at Home (ACH) program, and to evaluate the provider response and the patient characteristics that triggered the BPA.Design, Setting, and ParticipantsWe conducted a retrospective multicenter study of hospitalized patients who triggered the BPA notification for ACH eligibility between March and December 2021 at Mayo Clinic in Jacksonville, FL and Mayo Clinic Health System in Eau Claire, WI. We extracted demographic and diagnosis data from the patients as well as characteristics of the providers who received the BPA notification.InterventionThe BPA was developed based on the ACH inclusion and exclusion criteria, which were derived from clinical guidelines, literature review, and expert consensus. The BPA was integrated into the EHR and displayed a pop‐up message to the provider when a patient met the criteria for ACH eligibility. The provider could choose to refer the patient to ACH, dismiss the notification, or defer the decision.Main Outcomes and MeasuresThe main outcomes were the number and proportion of BPA notifications that resulted in a referral to ACH, and the number and proportion of referrals that were accepted by the ACH clinical team and transferred to ACH. We also analyzed the factors associated with the provider's decision to refer or not refer the patient to ACH, such as the provider's role, location, and specialty.ResultsDuring the study period, 8962 notifications were triggered for 2847 patients. Providers opted to refer 711 (11.4%) of the total notifications linked to 324 unique patients. After review by the ACH clinical team, 31 of the 324 referrals (9.6%) met clinical and social criteria and were transferred to ACH. In multivariable analysis, Wisconsin nurses, physician assistants, and in‐training personnel had lower odds of referring the patients to ACH when compared to attending physicians.
Diagnostic and Prognostic Potential of Multiparametric Renal MRI in Kidney Transplant Patients
Authors: Echeverria‐Chasco Rebeca , Martin‐Moreno Paloma L. , Aramendía‐Vidaurreta Veronica , Garcia‐Ruiz Leyre , Mora‐Gutiérrez José María , Vidorreta Marta , Villanueva Arantxa , Cano David , Bastarrika Gorka , Garcia‐Fernandez Nuria , Fernández‐Seara Maria A. 
Published: January 2024

BackgroundMultiparametric MRI provides assessment of functional and structural parameters in kidney allografts. It offers a non‐invasive alternative to the current reference standard of kidney biopsy.PurposeTo evaluate the diagnostic and prognostic utility of MRI parameters in the assessment of allograft function in the first 3‐months post‐transplantation.Study TypeProspective.Subjects32 transplant recipients (54 ± 17 years, 20 females), divided into two groups according to estimated glomerular filtration rate (eGFR) at 3‐months post‐transplantation: inferior graft function (IGF; eGFR<45 mL/min/1.73 m2, n = 10) and superior graft function (SGF; eGFR ≥ 45 mL/min/1.73 m2, n = 22). Further categorization was based on the need for hemodialysis (C1) and decrease in s‐creatinine (C2) at 1‐week post‐transplantation: delayed‐graft‐function (DGF: n = 4 C1, n = 10 C2) and early graft‐function (EGF: n = 28 C1, n = 22 C2).Field Strength/Sequence3‐T, pseudo‐continuous arterial spin labeling, T1‐mapping, and diffusion‐weighted imaging.AssessmentMultiparametric MRI was evaluated at 1‐week in all patients and 3‐months after transplantation in 28 patients. Renal blood flow (RBF), diffusion coefficients (ADC, ΔADC, D, D, D*, flowing fraction f), T1 and T1 were calculated in cortex and medulla. The diagnostic and prognostic value of these parameters, obtained at 3‐months and 1‐week post‐transplantation, respectively, was evaluated in the cortex to discriminate between DGF and EGF, and between SGF and IGF.Statistical TestsLogistic regression, receiver‐operating‐characteristics, area‐under‐the‐curve (AUC), confidence intervals (CIs), analysis‐of‐variance, t‐test, Wilcoxon‐Mann–Whitney test, Fisher's exact test, Pearson's correlation. P‐value<0.05 was considered significant.ResultsDGF patients exhibited significantly lower cortical RBF and f and higher D*. The diagnostic value of MRI for detecting DGF was excellent (AUC = 100%). Significant differences between patients with IGF and SGF were found in RBF, ∆T1, and ∆D. Multiparametric MRI showed higher diagnostic (AUC = 95.32%; CI: 88%–100%) and prognostic (AUC = 97.47%, CI: 92%–100%) values for detecting IGF than eGFR (AUC = 89.50%, CI: 79%–100%).Data ConclusionMultiparametric MRI may show high diagnostic and prognostic value in transplanted patients, yielding better results compared to eGFR measurements.Level of Evidence2Technical EfficacyStage 1
AI‐Enhanced Detection of Clinically Relevant Structural and Functional Anomalies in MRI: Traversing the Landscape of Conventional to Explainable Approaches
Authors: Khosravi Pegah , Mohammadi Saber , Zahiri Fatemeh , Khodarahmi Masoud , Zahiri Javad 
Published: January 2024

Anomaly detection in medical imaging, particularly within the realm of magnetic resonance imaging (MRI), stands as a vital area of research with far‐reaching implications across various medical fields. This review meticulously examines the integration of artificial intelligence (AI) in anomaly detection for MR images, spotlighting its transformative impact on medical diagnostics. We delve into the forefront of AI applications in MRI, exploring advanced machine learning (ML) and deep learning (DL) methodologies that are pivotal in enhancing the precision of diagnostic processes. The review provides a detailed analysis of preprocessing, feature extraction, classification, and segmentation techniques, alongside a comprehensive evaluation of commonly used metrics. Further, this paper explores the latest developments in ensemble methods and explainable AI, offering insights into future directions and potential breakthroughs. This review synthesizes current insights, offering a valuable guide for researchers, clinicians, and medical imaging experts. It highlights AI's crucial role in improving the precision and speed of detecting key structural and functional irregularities in MRI. Our exploration of innovative techniques and trends furthers MRI technology development, aiming to refine diagnostics, tailor treatments, and elevate patient care outcomes.Level of Evidence5Technical EfficacyStage 1.
Aggravation of global maize yield loss risk under various hot and dry scenarios using multiple types of prediction approaches
Authors: Yin Xiaomeng , Leng Guoyong , Huang Shengzhi , Peng Jian 
Published: January 2024

AbstractHigh temperature and drought are widely known to cause a reduction of crop yield, but the simultaneously occurring risks in major producing countries and the associated uncertainty across various climate change scenarios remain unclear at the global scale. Here, we evaluate global maize yield loss risk (i.e., the probability of yield reduction by over 10% relative to historical trend yield during 1981–2010) across 30 hot and dry scenarios using regression, machine learning and process‐based models. Besides examining yield loss risk in a single country, we predict the potential risks simultaneously occurring in the top two and top ten producing countries. The three approaches agree on the aggravation of yield loss risk under dry and hot scenarios, but show large discrepancy in the magnitude and sensitivities. Specifically, 2°C warming alone could lead to a global yield loss risk of 73%, 100% and 62% based on regression, long‐short term memory (LSTM) and process‐based models, respectively, and warming‐induced risks can be further aggravated by droughts especially in process models. Global yield loss by over 10% would even become the new norm (i.e., yield loss probability is 100%) when temperature increases by over 2°C in some models. Importantly, the probabilities of yield loss simultaneously occurring in the top two countries (i.e., United States and China) and top ten countries are unexpectedly high and could even become 100% under extreme hot and dry scenarios. Our results highlight the large risks that future climate change may bring to multiple exporting and importing countries simultaneously, thus threating global food market and security. We also emphasize the important value of using different types of prediction approaches for yield projection under hot and dry scenarios, which enables more realistic estimation of uncertainty range than a single type of model.
Bioactive foamulsion gels: a unique structure prepared with gellan gum and Acanthophyllum glandulosum extract
Authors: Sabeghi Yeganeh , Varidi Mehdi , Nooshkam Majid 
Published: January 2024

AbstractBACKGROUNDFoamulsions have become increasingly popular in the food industry due to their ability to enhance the textural, sensory and health‐promoting properties of food products. This study was therefore aimed to design and prepare a novel gelled structure, foamulsion gel containing 0–600 g L−1 oil, with gellan gum (GG; 7, 10 and 13 g L−1) and saponin‐rich antioxidant Acanthophyllum glandulosum extract (AGE; 2, 6 and 10 g L−1).RESULTSThe interaction between components was confirmed by infrared spectroscopy. The overrun and porosity of the foamulsion gels increased with antioxidant AGE (1.30 times) and reduced with oil (up to ca 70% and 30%, respectively) and GG levels. The systems were highly stable, and no water or oil was released during the physical stability experiments. Microscopic images showed that the size of air cells was significantly larger than that of oil droplets. The foamulsion gels based on 13 g L−1 GG and 10 g L−1 AGE had markedly higher elastic (G′) and viscous (G′′) moduli than other samples, and exhibited an elastic and solid‐like behavior (G′ > G′′). The highest gel firmness was found in oil‐free sample, and the presence of oil resulted in a lower firmness induced by the larger size and lubrication effect of oil droplets.CONCLUSIONAs a result, the interactions between AGE, GG and oil could lead to the creation of new aerated structures known as bioactive foamulsion gels. These gels exhibit excellent foamability, stability and viscoelasticity and may find applications in the development of novel, healthy and low‐calorie aerated foods. © 2024 Society of Chemical Industry.
How do leisure activities impact leisure domain and life domain satisfaction and subjective well‐being?
Authors: Kim Dohee , Park Jeongdoo , Park Byung‐Jin 
Published: January 2024

AbstractThis study examines the impact of leisure activities on leisure domain and life domain satisfactions and subjective well‐being (SWB) and explores the differences between genders in these associations, using data from 316 middle‐aged adults. The results suggest that sports and travel & outdoor activities have the greatest impact on physiological, psychological, and relaxing satisfactions. Social activities are key ingredients in social, psychological, and physiological satisfactions as seen by men, whereas cultural activities and hobbies are important in women's psychological satisfaction. While relaxing and social satisfactions are important in men's SWB, psychological satisfaction is the most important factor in women's SWB.
Domestic midscale chain hotel brands' effectiveness in research and development: An exploratory study
Authors: Lin Michael S. , Lin Wanyu , Xiao Qu 
Published: January 2024

AbstractWhile many midscale chain hotel brands in China's domestic market have developed rapidly since 2010, it is still unclear how a new midscale chain hotel brand can be most effectively researched and developed. Drawing from resource‐advantage theory, this study aimed to understand the effectiveness of six key attributes of new domestic midscale chain hotel brands and map them onto a research and development (R&D) competitive position matrix. The results show that the actual R&D process lasts beyond the opening of the first hotel of the new brand and requires a further 2‐year maturation period. This study contributes to the literature by creating a maturation system that could play a key role in the effectiveness of the R&D underlying a chain hotel's brand development. It also provides a compelling tool for monitoring the effectiveness of domestic midscale chain hotel brands' R&D.
Left Ventricular Vortex Characteristics in Fetuses With Coarctation of the Aorta by Blood Speckle‐Tracking Echocardiography
Authors: Zhou Dan , Xu Ran , Liu Yushan , Yang Yang , Wu Zhongshi , Luo Yuanchen , Zeng Shi 
Published: January 2024

ObjectivesThe aims of this study were to assess the vortex characteristics of left ventricle (LV) in fetuses with coarctation of the aorta (CoA) using high–frame rate ultrasound with blood speckle‐tracking (BST) and explore its relationships with cardiac function and morphology parameters.MethodsThirty fetuses with CoA and 30 gestational‐age matched normal fetuses were included in this cross‐sectional study. The area, length, width, and position of the vortex in the LV were recorded and quantitatively analyzed by BST echocardiography. The associations of vortex properties with ventricular function and morphology were also determined.ResultsBased on BST imaging, the LV vortex can be observed in 93% of the fetuses. The fetuses with CoA exhibited significantly larger and wider vortex than the controls (P < .05). Linear regression analysis indicated that vortex area was positively related to sphericity index of LV as well as isovolumic relaxation time (r = .52, P = .003 and r = .42, P = .021). There was a negative correlation between vortex area and mitral valve size (r = −.443, P = .014). No significant association was found between vortex area and myocardial performance index and aortic isthmus size.ConclusionsIt is feasible to quantitatively evaluate the left ventricular vortex in fetuses by BST. The fetuses with CoA exhibited greater vortex area and width, and the altered vortex property is associated with geometry of LV. This will facilitate our comprehension of the unique flow patterns and early cardiac remodeling in fetuses with CoA.
Circulating TWEAK levels in patients with acne vulgaris: Effect of oral isotretinoin therapy
Authors: Ibrahim Hassan M. , Hassan Mohammed H. , El‐Taieb Moustafa A. , Abdel‐Hamid Soheir , Younis Ali , Ali Mahmoud , Amer Mohammed , Hegazy Eisa M. 
Published: January 2024

AbstractBackgroundUpdates on the aetiopathogenesis of acne vulgaris, particularly the inflammatory process, are becoming more and more clear. The TNF superfamily includes tumor necrosis factor (TNF) related weak inducer of apoptosis (TWEAK). It plays a significant part in a variety of inflammatory skin conditions, including psoriasis, alopecia areata and many others. However, its role in acne vulgaris remains questionable.ObjectivesWe aim in this research to evaluate the circulating levels of TWEAK in various severities of acne vulgaris patients and their blood levels before and after oral treatment with isotretinoin.MethodsThis study includes 100 acne vulgaris patients and 100 healthy controls in a case‐control design. All cases, ranging in severity, were treated for 3 months with oral isotretinoin. Enzyme‐linked immunosorbent assay technique was used to measure serum TWEAK before and after 3 months of isotretinoin treatment.ResultsThe serum TWEAK levels were significantly higher in patients than the healthy volunteers (p < 0.001). There were significantly higher serum TWEAK levels with increasing acne vulgaris severity. Additionally, a significant decrease in serum TWEAK level after treatment by oral isotretinoin of AV patients (p < 0.001).ConclusionsTWEAK may play an important role in aetiopathogenesis and the severity of acne vulgaris. Also, oral isotretinoin may target TWEAK in the treatment and alleviate the acne vulgaris.
Tinea capitis due to Trichophyton soudanense and Microsporum audouinii: A surprising finding
Authors: Krefting Frederik , Livingstone Elisabeth , Sondermann Wiebke , Thielmann Carl M. , Placke Jan‐Malte , Schadendorf Dirk , Polan Christina , Rath Peter Michael , Scharmann Ulrike , Uhrlaß Silke , Nenoff Pietro 
Published: January 2024

AbstractTinea capitis is a prevalent dermatophyte infection among German children, primarily caused by Microsporum canis, Trichophyton mentagrophytes and Trichophyton benhamiae. Other pathogens, such as T. soudanense and M. audouinii, have also been identified in Germany. This case report describes a 10‐year‐old Angolan girl with chronic osteomyelitis who was brought to Germany for treatment, which was organized by the Friedensdorf International (Peacevillage International). In addition to chronic osteomyelitis of the lower leg, the patient presented with alopecic areas of the scalp with adherent scales, which raised the suspicion of tinea capitis. Fungal cultivation and polymerase chain reaction (PCR) diagnostics revealed a coinfection of T. soudanense and M. audouinii, which, to the best of our knowledge, has not been previously reported in Europe. After 4 weeks of systemic terbinafine treatment and topical use of ciclopirox solution and clotrimazole cream, there was a marked improvement in the patient's condition. This was confirmed by a negative fungal culture and PCR; no adverse events were reported. This report highlights a rare dual dermatophyte infection caused by T. soudanense and M. audouinii in Europe, and the successful response to treatment with systemic terbinafine and topical ciclopirox solution as well as clotrimazole cream.
Evodiamine inhibits EPRS expression to regulate glutamate metabolism and proliferation of oral squamous cell carcinoma cells
Authors: Lin Li‐Qi , Lv Si‐Yi , Ren Hao‐Zhe , Li Rong‐Rong , Li Lin , Pang Yun‐Qing , Wang Jing 
Published: January 2024

AbstractThe effects of evodiamine (EVO) on oral squamous cell carcinoma (OSCC) are not yet understood. Based on our earlier findings, we hypothesized that evodiamine may affect OSCC cell proliferation and glutamate metabolism by modulating the expression of EPRS (glutamyl‐prolyl‐tRNA synthetase 1). From GEPIA, we obtained EPRS expression data in patients with OSCC as well as survival prognosis data. An animal model using Cal27 cells in BALB/c nude mice was established. The expression of EPRS was assessed by immunofluorescence, Western blotting, and quantitative PCR. Glutamate measurements were performed to evaluate the impact of evodiamine on glutamate metabolism of Cal27 and SAS tumor cells. transient transfection techniques were used to knock down and modulate EPRS in these cells. EPRS is expressed at higher levels in OSCC than in normal tissues, and it predicts poor prognosis in patients. In a nude mouse xenograft model, evodiamine inhibited tumor growth and the expression of EPRS. Evodiamine impacted cell proliferation, glutamine metabolism, and EPRS expression on Cal27 and SAS cell lines. In EPRS knockdown cell lines, both cell proliferation and glutamine metabolism are suppressed. EPRS's overexpression partially restores evodiamine's inhibitory effects on cell proliferation and glutamine metabolism. This study provides crucial experimental evidence supporting the potential therapeutic application of evodiamine in treating OSCC. Evodiamine exhibits promising anti‐tumor effects by targeting EPRS to regulate glutamate metabolism.