bluuebunny/crossref_metadata_2025_split huggingface dataset:
A Meaning‐Centered Intervention for Undergraduate Women With High Weight and Shape Concerns—Replication of a Randomized Controlled Trial
Authors: Schutzeichel Franziska , aan het Rot Marije , van Doornik Sanne F. W. , Glashouwer Klaske A. , Frey Mirjam I. , de Jong Peter J. 
Published: January 2025

ABSTRACTObjectiveRecent studies underscore the relevance of life meaning to the maintenance of eating disorders. A previously conducted randomized controlled trial tested a meaning‐centered intervention for female university students with high weight and shape concerns. After a 6‐week online intervention led by a trainer, participants in the intervention condition scored higher on life meaning and lower on eating disorder symptoms and general distress compared to a waitlist group.MethodGiven that the original study took place during COVID‐19, this study replicated the design to test the findings' robustness.ResultsCompared to the waitlist condition (n = 68), participants in the intervention condition (n = 63) again scored higher on the presence of life meaning at post‐assessment and follow‐up. Participants in the intervention condition also showed moderately lower internalizing symptoms at both timepoints, whereas eating disorder symptoms were only reduced in those with relatively high baseline symptom severity.ConclusionsThus, also without social distancing measures, the intervention increased life meaning and reduced eating disorder symptoms and comorbid internalizing symptoms in women with weight and shape concerns.
Physico‐Chemical Characteristics, Antioxidant Activities, and ACE Inhibitory Potential of Pakistani Dahi Supplemented With Date Fruit Paste
Authors: Qureshi Tahir Mahmood , Nadeem Muhammad , Muhammad Ghulam , Abbas Waseem , Akram Kashif , Hussain Majid , Manzoor Zahid , Ibrahim Salam A. 
Published: January 2025

ABSTRACTDahi as well as date fruits are considered very important in our diet due to the presence of nutritional and medicinal properties. The objective of this study was to evaluate the antioxidant potential and angiotensin‐I‐converting enzyme (ACE) inhibitory activity of date paste added to indigenous dahi during storage (0–8 days, 5°C). The prepared dahi was also evaluated for its physico‐chemical characteristics and microbiological and sensorial quality during the storage period. The freshly prepared dahi supplemented (prepared from both cow's and buffalo's milk) with different date fruit pastes showed less syneresis, improved water holding capacity as well as sensorial quality compared to the control. The freshly prepared buffalo's milk dahi supplemented with different date fruit pastes performed the best with regard to TP contents (0.54–0.89 mg gallic acid equivalent/g), TF contents (163.43–243.42 mg quercetin equivalent/100 g), FRAP (733.11–898.66 μg ascorbic acid equivalent/g), and TAC (164.30–254.10 mg ascorbic acid equivalent/100 g) compared to the control. Regarding ACE inhibition, the freshly prepared buffalo's milk dahi supplemented with date paste showed higher values (61.36%–72.43%) than the control (49.03%). The dahi prepared from buffalo's milk exhibited improved physico‐chemical characteristics, antioxidant as well as ACE inhibition (%) than those of cow's milk dahi. It was concluded that dahi supplemented with date pastes from different varieties exhibited improved physico‐chemical characteristics, antioxidant activity as well as ACE inhibition (%) than those of control dahi.
Exploring the Mechanism of Action and Potential Targets of Saorilao‐4 Decoction in the Treatment of Pulmonary Fibrosis in Rats by Metabolomics
Authors: Liu Jiali , Song Xinni , Fu Xinyue , Niu Shufang , Chang Hong , Shi Songli , Yang Meiqing , Wang Peng , Bai Wanfu 
Published: January 2025

ABSTRACTPulmonary fibrosis (PF) is a chronic progressive disease marked by alveolar epithelial cell damage. Saorilao‐4 decoction (SRL), a traditional Mongolian prescription, has demonstrated therapeutic effects on PF, though its mechanism of action remains elusive. This study used a bleomycin‐induced fibrosis rat model to evaluate SRL's effects by measuring inflammatory factors, assessing fibrosis‐related indices, and performing histopathological lung examinations. Serum metabolite levels in the experimental groups were measured using high‐performance liquid chromatography coupled with mass spectrometry. Data analysis involved principal component and partial least‐squares discriminant analyses, followed by functional enrichment analysis of differential metabolites. SRL significantly ameliorated alveolar interstitial injury, fibrosis, and metabolic disorders induced by bleomycin. Additionally, we identified 71 metabolic components related to PF progression, including sphingolipids and fatty acids. Administration of SRL affected 59 metabolic components involved in purine, cysteine and methionine, and arginine and proline metabolisms. Specifically, SRL regulated the levels of hexadecanoic acid, S‐adenosylmethionine, 3‐oxopalmitoyl coenzyme A, and dodecanoic acid metabolites, thereby improving the metabolic course of PF. In conclusion, this study offers insights into the potential mechanisms of SRL in treating PF from a metabolomics perspective. It provides valuable information for its clinical application.
Thermal Diffusion Effect Analysis of Micropolar Nanofluid Flowing on Inclined Surface: A Chemical Engineering Case Study
Authors: Shankar Goud B. , Jamshed Wasim , Ahmad Hijaz , Safdar Rabia , Isa Siti Suzilliana Putri Mohamed , Hussain Syed M. , Bayram Mustafa , Dharmaiah G. 
Published: January 2025

ABSTRACTThis investigation was carried out to study the microrotational flow of nanoliquids across an extensible surface. The dispersion of nanomaterials in everyday liquids is becoming a major focus of nanotechnology. Dispersing nanoparticles in a conventional liquid increases its thermal conductivity, which is useful for both generating and transferring energy. The primary focus of this study has been on energy transportation. Thermal radiations and Soret implications were used in this investigation. The Soret impacts are also taken into account. Here, the numerical research is based on the Buongiorno model. Using suitable similarity conversions, the flow mathematical equations are converted into the nonlinear ordinary differential equations. This study makes use of the popular numerical bvp4c method. Graphs and tables are used to illustrate the physical quantities, which include a number of impacts that are caused by the constraints of the component. The key findings are that high magnetic field factor, thermophoresis factor, Brownian motion factor, and radiation factor cause high‐temperature distribution. Moreover, thermophoresis and Brownian motion factors are responsible for enhancing the variation of Nusselt and Sherwood numbers. The growth in Nusselt number is controlled by the material factor, Lewis number, radiation factor, Soret number, and inclination angle. The presence of thermophoresis parameter, radiation factor, and inclination angle generate growth in Sherwood number.
Genetic Variants of the IL‐23/IL‐17 Axis and Its Association With Periodontal Disease: A Systematic Review
Authors: Rodríguez‐Montaño Ruth , Alarcón‐Sánchez Mario Alberto , Lomelí‐Martínez Sarah Monserrat , Martínez‐Bugarin Cristina Hermila , Heboyan Artak 
Published: January 2025

ABSTRACTBackgroundThe objective of this systematic review was to identify genetic variants of the IL‐23, IL‐17, IL‐23R and IL‐17R genes and isoforms and its possible association with increased development of periodontitis and peri‐implantitis.MethodsA systematic review was prepared according to the guidelines, registered in the OSF database with the registration number: 10.17605/OSF. IO/X95ZC. The electronic search was performed in four databases: PubMed, Scopus, Web of Science, and Google Scholar from 1984 until March 15th, 2024. The JBI Critical Appraisal Checklist for Case‐Control Studies was used to assess the quality of included studies.ResultsEighteen papers with a case‐control design were those that ultimately met the eligibility criteria. A total of 3904 individuals (2315 with periodontitis and 90 with peri‐implantitis), and 1589 healthy subjects) were studied. The age range of the study population was 14–70 years, with a mean age ± (SD) of 40.43 ± 6.33 years. A total of 28 genetic variants corresponding to the IL‐17A (rs 2275913, rs 3819024, rs 10484879) IL‐17F (rs 763780), IL‐17R (rs 879576) and IL‐23R (rs 11209026) genes were analyzed in this study. Six (33.3%) studies found an association between the IL‐17A 197 G/A (rs 2275913) genetic variant and peri‐implantitis and periodontitis. One study (5.5%) found an association between the IL‐17A rs10484879 variant and peri‐implantitis and periodontitis.ConclusionSix polymorphisms were evaluated, highlighting rs 2275913 of the cytokine IL‐17A in patients with periodontitis or peri‐implantitis. Only 50% of studies found an association despite having a small sample. This suggests that other factors such as the degree of disease, systemic diseases and ethnic groups studied may play a role.
Binder‐Free Highly Porous Bi2Se3‐MXene‐P Film Electrode Toward High‐Performance Asymmetric Capacitor
Authors: Wang Jiangang , Huang Lingyan , Chen Gongyu , Tang Jijun , Li Shiyun , Liu Lina , Ye Yonglin , Chen Xuecheng 
Published: January 2025

ABSTRACTThe restacking of single‐layer MXene has seriously hampered its wide applications. To address this issue, Bi2Se3‐modified porous MXene (Bi2Se3‐MXene‐P) films with highly porous structure were selectively prepared using a template method, the prepared films exhibit large specific surface area, good conductivity, high volumetric capacity, and excellent flexibility. The introduction of Bi2Se3 acts as the spacers can not only effectively prevent the restacking of single‐layer MXene but also enlarge the interlayer distance of MXene, leading to increased surface area and improved electrolyte electron transportation. More importantly, Bi2Se3 can provide more active sites to further improve the electrochemical performance in capacitor application. Benefiting from these properties, the Bi2Se3‐MXene‐P film electrode shows outstanding volumetric capacities of 1407.6 F cm−3 at 0.5 A g−1 in 1M AlCl3 electrolyte. To assess the electrochemical behavior for practical applications, the Bi2Se3‐MXene‐P//Al soft‐pack devices were assembled. Volumetric capacities of the Bi2Se3‐MXene‐P//Al soft‐pack devices decreased from 214.1 F cm−3 at 0.5 A g−1 to 115.7 F cm−3 at 5 A g−1. Additionally, when it switched back to 0.5 A g−1, the volumetric capacity could recover to 210.1 F cm−3 demonstrating its excellent rate capability. Moreover, the Bi2Se3‐MXene‐P//Al soft‐pack Al‐ion device exhibits the capacitance retention of 77.4% after 5000 charge–discharge cycles. The device also displays a high energy density of 14.8 Wh kg−1 at 130.7 W kg−1 power density. The present work demonstrates the potential application of the Bi2Se3‐MXene‐P film electrode in flexible energy storage devices.
Sarcolemmal Excitability Properties of the Trapezius
Authors: Lycett Mitchell J. , Lee James , Boland‐Freitas Robert , Ng Karl 
Published: January 2025

ABSTRACTIntroduction/AimsThe sarcolemma can be probed in vivo using muscle excitability recordings. These techniques have been applied to the tibialis anterior and brachioradialis muscles in healthy and diseased states. We aimed to study and validate the trapezius as a more proximal muscle to be used for myopathic conditions.MethodsMuscle velocity recovery cycles (MVRCs) and frequency ramp recordings were performed on the trapezius of 29 healthy controls. These recordings were compared to tibialis anterior recordings from 74 healthy controls.ResultsOverall, the recorded MVRC and frequency ramp recordings were similar between the trapezius and tibialis anterior. The mean relative refractory period (MRRP) was shorter in the trapezius (3.29 vs. 3.71 ms), but this is explained by differences in muscle temperature.DiscussionThe trapezius demonstrates similar MVRC and frequency ramp parameters to the more commonly studied tibialis anterior. The trapezius is technically easy to study using muscle excitability techniques and therefore presents itself as a promising muscle to study sarcolemmal properties in conditions that preferentially affect the proximal musculature.
Platelet‐Rich Plasma for Treating COVID‐19‐Related Anosmia, Hyposmia, and Parosmia: A Controlled Longitudinal Study
Authors: Lechien Jerome R. , Saussez Sven 
Published: January 2025

AbstractObjectiveTo investigate the effectiveness of platelet‐rich plasma (PRP) injection into the olfactory clefts of coronavirus disease 2019 (COVID‐19) patients with persistent anosmia, hyposmia, and parosmia.Study DesignControlled study.SettingMulticenter study.MethodsFrom March 2022 to July 2024, 514 COVID‐19 patients undergoing PRP injection and olfactory training versus olfactory training (controls) for a persistent olfactory dysfunction (OD) were consecutively recruited from two medical centers. Subjects were evaluated from pre‐ to 3 months post‐injection with the olfactory disorder questionnaire (ODQ) and the threshold, discrimination, and identification (TDI) test. Olfactory outcomes were compared between controls and patients considering the type of OD (anosmia, hyposmia, and parosmia).ResultsThe PRP group was composed of 416 patients with anosmia (N = 111; 26.7%), hyposmia (N = 160; 38.5%), and parosmia (N = 145; 34.9%). The baseline ODQ of patients with parosmia was significantly higher than those of the other groups (P = .001). The increase in TDI subscores and total score was significantly higher in all PRP subgroups compared to controls (P = 0.001). The ODQ significantly reduced from pre‐ to post‐PRP injection in hyposmia and parosmia groups (P = 0.001). Patients with parosmia showed a significantly greater reduction in ODQ scores compared to the control group. The 3‐month TDI score was negatively influenced by the age of patients (rs = −0.263; P = 0.001) and the duration of OD (rs = −0.213; P = .001).ConclusionPatients with parosmia experienced a stronger impact of OD on quality of life (QoL), and showed greater QoL improvement following PRP injections compared to other groups.
COVID Effects on Adherence to Joint Committee on Infant Hearing Newborn Screening Recommendations
Authors: Behzadpour Hengameh K. , Chappetto Jennifer , Ambrose Tracey , Sideris Irene , Buxton Claire , Reilly Brian K. , Robinson Tommie L. , Mahshie James , Preciado Diego A. 
Published: January 2025

AbstractObjectiveDespite significant improvements in universal newborn hearing screenings (NBHS), infants are still lost to follow‐up (LTF) after failed screening, delaying timely diagnosis and intervention. The challenges during the COVID‐19 pandemic and its response likely exacerbated timely adherence to early diagnosis and intervention. This study aimed to assess the LTF rate for infants who did not pass their NBHS within Washington, DC and compare the LFT before and during the pandemic.Study DesignCohort study analyzing variables potentially impacting LTF.SettingWeb‐based analysis of DC Oz e‐Screener Plus for NBHS reports.MethodsMultivariate and univariate regression analyses were used to identify significant demographic and clinical factors from March 2019 to March 2021.ResultsOf the 15,661 born during the period analyzed, 830 (5.3%) infants did not pass their initial hearing screening: 406 (48.9%) infants in the pre‐COVID group and 424 (51.1%) infants in the COVID group. Of those infants failing their initial screening, 388 (46.7%) did not pass a follow‐up outpatient screening. Of these, 342 (88.1%) had no record of receiving a Diagnostic Auditory Brainstem Response assessment. The overall LTF rate in the pre‐COVID group was 90.7% compared to 83% in the COVID group. Multivariate analyses showed that male gender (odds ratio [OR] = 1.3), income <100 K (OR = 1.9), wards 7 and 8 (OR = 1.9), and pre‐COVID group (OR = 0.7) were statistically associated with LTF.ConclusionThere are many factors impacting LTF rates and future follow‐up when using the protocols recommended by the Joint Committee on Infant Hearing. This study will be the basis for implementing planned improvement strategies for reducing LTF rates.
Obstructive Sleep Apnea Surgery Practice Patterns in the United States: 2019
Authors: Cho Jae Hoon , Liu Christine , Badash Ido , Kezirian Eric J. 
Published: January 2025

AbstractObjectiveThis study aims to determine the volumes and facility costs/charges for procedures used to treat the pharyngeal airway in adults with obstructive sleep apnea (OSA) in the United States in 2019, and to explore whether specific patient and facility characteristics are associated with procedure type and costs/charges.Study DesignA cross‐sectional study.SettingNationwide databases (National Inpatient Sample and the Nationwide Ambulatory Surgery Sample).MethodsOSA procedures were identified in both inpatient and outpatient settings using both databases. Chi‐squared tests and regression analyses examined procedure volume, type, and facility costs/charges, with adjustments made for specific patient and facility characteristics.ResultsIn 2019, an estimated 18,526 discharges/encounters involving OSA surgery were performed in inpatient and outpatient settings. These included 12,938 palate surgeries, 1350 hypopharyngeal surgeries, 3054 unilateral hypoglossal nerve stimulation (HNS) system implantations, and 1840 maxillomandibular advancement procedures. The odds of undergoing HNS, as compared to almost all other categories of procedures, were generally greater for those aged 40 years or older (compared to younger patients) but generally lower for almost all non‐white groups compared to white patients. Younger patients were more likely to undergo isolated palate surgery, compared to other surgical procedure types. Facility costs (inpatient) and charges (outpatient) were greater for HNS than other procedure types, and there were differences variably associated with patient and facility characteristics.ConclusionSurgical treatment is performed in approximately 0.03% to 0.77% of all adults in the United States with OSA annually. Specific factors are associated with procedure type and facility costs/charges.
Differences in Negotiated Facility Fees for Otolaryngology Procedures at Ambulatory Surgery Centers and Hospitals
Authors: Walia Anika S. , Xiao Roy , Hao Daphne T. , Rathi Vinay K. , Sethi Rosh K. V. , Gray Stacey T. 
Published: January 2025

AbstractWhile outpatient otolaryngology procedures have been increasingly performed at ambulatory surgery centers (ASCs), the cost differences compared to hospital outpatient departments (HOPDs) remain unclear. Utilizing newly available data collected from Turquoise Health's Rate Sense as required under the Transparency in Coverage rule, we assess, in this cross‐sectional analysis, the differences in negotiated facility fees between ASCs and HOPDs for 20 common otolaryngologic procedures. Analyzing data from 4613 ASCs and 2382 hospitals, we found significantly higher facility fees at HOPDs, with a median relative price difference of +146% (P < .0001). This may be explained by greater infrastructure costs and market power differences between facilities. Our findings suggest that further shifting outpatient otolaryngology procedures toward ASCs could yield substantial cost reductions across health care systems. Additional research is needed to ensure safe and cost‐effective patient selection for ASCs.
Immunohistochemical Analysis of Androgen Receptor Expression Predicts the Prognosis of Metastatic Castration‐Sensitive Prostate Cancer Patients Receiving Abiraterone Acetate
Authors: Nishimoto Mitsuhisa , De Velasco Marco A. , Yamamoto Yutaka , Fujimoto Saizo , Akashi Yasunori , Toyoda Shingo , Hashimoto Mamoru , Adomi Shogo , Banno Eri , Saito Yoshitaka , Minami Takafumi , Hirayama Akihide , Yoshimura Kazuhiro , Uemura Hirotsugu , Fujita Kazutoshi 
Published: January 2025

ABSTRACTBackgroundThe efficacy of abiraterone acetate varies among patients with high‐risk metastatic castration‐sensitive prostate cancer (mCSPC). Both androgen receptor (AR) and cytokeratin 18 (CK18) are markers of the luminal lineage of prostate cancer, and their expression levels have been suggested to affect the response to androgen deprivation therapy (ADT). This study aimed to predict the efficacy of abiraterone acetate in high‐risk mCSPC via immunohistochemical staining of biopsy specimens obtained at the time of prostate cancer diagnosis.MethodsWe retrospectively analyzed 44 patients treated with abiraterone acetate in combination with ADT. AR and CK18 expression in prostate biopsy specimens were assessed using immunohistochemical staining.ResultsAR and CK18 staining was not significantly associated with overall survival (OS). However, low AR staining was significantly associated with a shorter time to castration‐resistant prostate cancer (TTCRPC) compared with high AR staining (log‐rank test, p = 0.018). Similarly, low CK18 staining was significantly associated with a shorter TTCRPC compared with high CK18 staining (log‐rank test, p = 0.037).ConclusionsImmunohistochemical analysis of AR or CK18 expression in biopsy specimens may serve as a predictive biomarker of high‐risk mCSPC treated with abiraterone acetate.Trial Registration: None
How Accurate Are Students in Self‐Assessing Their Conceptions of Evolution?
Authors: Hartelt Tim , Martens Helge 
Published: January 2025

ABSTRACTEvolution is challenging to understand for students. Frequently, students hold coexisting intuitive conceptions based on cognitive biases and scientific conceptions of evolution. For the self‐regulation of intuitive and scientific conceptions, metacognitive awareness is fundamental. However, students are mostly unaware of their conceptions. A criteria‐referenced self‐assessment of one's intuitive and scientific conceptions is one way to develop this metacognitive awareness and enhance conceptual knowledge. We investigated in a study with N = 432 upper secondary students how accurate students are in self‐assessing intuitive and scientific conceptions of evolution, which possible explanations for inaccurate self‐assessments exist, and which variables are related to self‐assessment accuracy (e.g., prior conceptual knowledge, metaconceptual awareness and regulation, and self‐efficacy). We found that self‐assessment accuracy was moderate, with students self‐assessing more intuitive and scientific conceptions than present. Possible explanations for inaccurate self‐assessments were incorrect understandings of concepts, excessive self‐assessments (of an intuitive concept in a context where it is appropriate; of a scientific concept despite incompleteness), and mix‐ups of concepts. Self‐assessment accuracy was predicted mainly by prior conceptual knowledge in terms of scientific conceptions and, in some analyses, by prior conceptual knowledge in terms of intuitive conceptions and self‐efficacy. The findings have important implications for using self‐assessment to develop metaconceptual awareness, for adjusting self‐assessments to students' preconditions (e.g., prior knowledge), and for designing teaching approaches in evolution and science education.