bluuebunny/crossref_metadata_2025_split huggingface dataset:
Sex and age differences in social and cognitive function in offspring exposed to late gestational hypoxia
Authors: Mabry Steve , Wilson E. Nicole , Bradshaw Jessica L. , Gardner Jennifer J. , Fadeyibi Oluwadarasimi , Vera Edward , Osikoya Oluwatobiloba , Cushen Spencer C. , Karamichos Dimitrios , Goulopoulou Styliani , Cunningham Rebecca L. 
Published: November 2023

Abstract
Background
Gestational sleep apnea is a hypoxic sleep disorder that affects 8–26% of pregnancies and increases the risk for central nervous system dysfunction in offspring. Specifically, there are sex differences in the sensitivity of the fetal hippocampus to hypoxic insults, and hippocampal impairments are associated with social dysfunction, repetitive behaviors, anxiety, and cognitive impairment. Yet, it is unclear whether gestational sleep apnea impacts these hippocampal-associated functions and if sex and age modify these effects. To examine the relationship between gestational sleep apnea and hippocampal-associated behaviors, we used chronic intermittent hypoxia (CIH) to model late gestational sleep apnea in pregnant rats. We hypothesized that late gestational CIH would produce sex- and age-specific social, anxiety-like, repetitive, and cognitive impairments in offspring.

Methods
Timed pregnant Long-Evans rats were exposed to CIH or room air normoxia from GD 15–19. Behavioral testing of offspring occurred during either puberty or young adulthood. To examine gestational hypoxia-induced behavioral phenotypes, we quantified hippocampal-associated behaviors (social function, repetitive behaviors, anxiety-like behaviors, and spatial memory and learning), hippocampal neuronal activity (glutamatergic NMDA receptors, dopamine transporter, monoamine oxidase-A, early growth response protein 1, and doublecortin), and circulating hormones in offspring.

Results
Late gestational CIH induced sex- and age-specific differences in social, repetitive, and memory functions in offspring. In female pubertal offspring, CIH impaired social function, increased repetitive behaviors, and elevated circulating corticosterone levels but did not impact memory. In contrast, CIH transiently induced spatial memory dysfunction in pubertal male offspring but did not impact social or repetitive functions. Long-term effects of gestational CIH on social behaviors were only observed in female offspring, wherein CIH induced social disengagement and suppression of circulating corticosterone levels in young adulthood. No effects of gestational CIH were observed in anxiety-like behaviors, hippocampal neuronal activity, or circulating testosterone and estradiol levels, regardless of sex or age of offspring.

Conclusions
Our results indicate that hypoxia-associated pregnancy complications during late gestation can increase the risk for behavioral and physiological outcomes in offspring, such as social dysfunction, repetitive behaviors, and cognitive impairment, that are dependent on sex and age.
A survey of technologies for automatic Dysarthric speech recognition
Authors: Qian Zhaopeng , Xiao Kejing , Yu Chongchong 
Published: November 2023

AbstractSpeakers with dysarthria often struggle to accurately pronounce words and effectively communicate with others. Automatic speech recognition (ASR) is a powerful tool for extracting the content from speakers with dysarthria. However, the narrow concept of ASR typically only covers technologies that process acoustic modality signals. In this paper, we broaden the scope of this concept that the generalized concept of ASR for dysarthric speech. Our survey discussed the systems encompassed acoustic modality processing, articulatory movements processing and audio-visual modality fusion processing in the application of recognizing dysarthric speech. Contrary to previous surveys on dysarthric speech recognition, we have conducted a systematic review of the advancements in this field. In particular, we introduced state-of-the-art technologies to supplement the survey of recent research during the era of multi-modality fusion in dysarthric speech recognition. Our survey found that audio-visual fusion technologies perform better than traditional ASR technologies in the task of dysarthric speech recognition. However, training audio-visual fusion models requires more computing resources, and the available data corpus for dysarthric speech is limited. Despite these challenges, state-of-the-art technologies show promising potential for further improving the accuracy of dysarthric speech recognition in the future.
Photoactivated chromophore-corneal cross-linking accelerates corneal healing in fungal keratitis: an updated meta-analysis
Authors: Liu Shuyi , Fang Shifeng , Zhang Lijun 
Published: November 2023

Abstract
Aim
To determine the effectiveness and safety of photoactivated chromophore-corneal cross-linking (PACK-CXL) adjuvant in infectious keratitis by April 5, 2022.

Methods
We searched randomized controlled trials (RCTs) comparing standard antibiotic treatment (SAT) plus PACK-CXL to SAT in infectious keratitis in Embase, MEDLINE with PubMed, Web of Science, and Cochrane Library. We independently screened and extracted data using predesigned tables. Cochrane’s risk-of-bias tool was utilized to examine the quality of RCTs. A random-effects model was employed to determine the overall effect size of the meta-analyses. Grading of Recommendations, and Assessment, Development and Evaluations (GRADE) was also performed to examine the quality of evidence.

Results
Seven eligible RCTs with 283 patients were acquired. Adjuvant PACK-CXL reduced the time needed to perform corneal healing in fungal keratitis (− 1.33 months; 95% CI, − 1.83 to − 0.42, I2 = 0%, P < 0.05) as compared to SAT alone. The risks of adverse events were not significantly different both in fungal and bacterial keratitis. Due to the substantial heterogeneity among studies, such as population, the type and severity of infectious keratitis, drug regimens of SAT, PACK-CXL protocol, and the judgment of subjective outcomes, the evidence grade was low.

Conclusion
Adjuvant PACK-CXL accelerates fungal keratitis healing as compared to SAT alone. But more rigorous RCTs are required to determine the clinical effectiveness and safety.
Effects of irrigation and rainfed practices on Normalized Difference Vegetative Index of Wheat (Triticum aestivum L.) and its Implications on Grain Yield in Northern China
Authors: Mazengo Tumaini Erasto Robert , Guo Zhongying , Liu Xiaoying , Wu Yingnan , Li Yuzhong , Gwandu Catherine 
Published: November 2023

AbstractFive (5) winter wheat genotypes were evaluated based on the Normalized Difference Vegetative Index (NDVI) under irrigation and rainfed conditions. A randomized complete block design in a split-plot arrangement was used with 30 treatment combinations during the two consecutive cropping seasons, from 2017 to 2019. The NDVI was used to evaluate the differences in wheat genotypes growth from the effects of irrigation and rainfed. The results indicated that NDVI values varied at all vegetative stages and that there were significant differences (p < 0.05) in NDVI indices among genotypes throughout the growth period, especially at the booting and grain-filling stages from the end of March to mid-May. However the indices started to decrease immediately after physiological maturity. In the entire study, the maximum NDVI was 0.82 for the Zhongmai-36 genotype, corresponding to a grain yield of 8.05 mg ha−1 and was obtained in irrigation group. The maximum NDVI in rainfed group was 0.78 from Zhongmai-36 and corresponded to the grain yield of 7.28 mg ha−1. This study suggests that among the other four genotypes, Zhongmai-36 could be prioritized under limited irrigation without compromising grain yield (GY). Since the NDVI, leaf area index (LAI) and GY related positively during the entire growth period therefore, can be used for the real time monitoring of wheat growth seasonal water requirements and grain yield simulation. This information could be used by agricultural stakeholders and decision-makers in early warning of food security concerning wheat productivity.
Analysis of Mechanical Properties and Microstructure of Nano- and Micro-SiO2 Materials as Cementitious Composite Binder
Authors: Kim Won-Woo , Moon Jae-Heum 
Published: November 2023

AbstractThis study evaluated the setting time, mechanical properties and microstructure of Portland cement (OPC) by adding SiO2 nano- and micro-particles. The setting time was reduced due to the pozzolanic reaction of the nano- and micro-SiO2, and the compressive strength was increased through a reduction in the porosity of the microstructure. When nano- and micro-SiO2 were used alone, micro-silica was the most effective in reduced the initial and final setting times and developing compressive strength. When two or more nano- and micro-SiO2 were used, a micro-sized binder and a small amount of nano-silica effectively improved performance as the setting time was reduced to 50–52% of that of ordinary Portland cement (OPC). It appears that a small amount of nano-silica could reduce the setting time and increase compressive strength because it caused the pozzolanic reaction and because the nanoparticles filled the pores between the silica fume and cement, which were composed of relatively large particles. This result could also be derived from compressive strength and microstructure analysis. Cement paste containing to nano- and micro-silica increased the strength by approximately 112% compared to OPC. Because nano-binders may cause a reduction in flow due to their large specific surface area, adding chemical admixture needs to be considered during mix design. In addition, the particle size distribution must be considered when nano- and micro-materials are used because an imbalance in particle size distribution can increase the pore size in the microstructure.
Anti-diarrheal drug loperamide induces dysbiosis in zebrafish microbiota via bacterial inhibition
Authors: Stevick Rebecca J. , Audrain Bianca , Bedu Sébastien , Dray Nicolas , Ghigo Jean-Marc , Pérez-Pascual David 
Published: November 2023

AbstractBackgroundPerturbations of animal-associated microbiomes from chemical stress can affect host physiology and health. While dysbiosis induced by antibiotic treatments and disease is well known, chemical, nonantibiotic drugs have recently been shown to induce changes in microbiome composition, warranting further exploration. Loperamide is an opioid-receptor agonist widely prescribed for treating acute diarrhea in humans. Loperamide is also used as a tool to study the impact of bowel dysfunction in animal models by inducing constipation, but its effect on host-associated microbiota is poorly characterized.ResultsWe used conventional and gnotobiotic larval zebrafish models to show that in addition to host-specific effects, loperamide also has anti-bacterial activities that directly induce changes in microbiota diversity. This dysbiosis is due to changes in bacterial colonization, since gnotobiotic zebrafish mono-colonized with bacterial strains sensitive to loperamide are colonized up to 100-fold lower when treated with loperamide. Consistently, the bacterial diversity of gnotobiotic zebrafish colonized by a mix of 5 representative bacterial strains is affected by loperamide treatment.ConclusionOur results demonstrate that loperamide, in addition to host effects, also induces dysbiosis in a vertebrate model, highlighting that established treatments can have underlooked secondary effects on microbiota structure and function. This study further provides insights for future studies exploring how common medications directly induce changes in host-associated microbiota.Graphical Abstract
Reliability analysis and uncertainty quantification of clay and sand slopes stability evaluated by Fellenius and Bishop’s simplified methods
Authors: Doan Nhu Son 
Published: November 2023

AbstractSlope stabilities are mainly designed using the conventional design approach (CDA), where the limit equilibrium methods (LEMs) are performed. Fellenius and Bishop’s simplified methods are the two commonly LEMs adopted as recommended in most design codes. In the design process of CDA, the safety factors (FS) of slopes are checked with specified FSs to ensure stability. The CDA has inherent drawbacks because the design process does not account for uncertainties. Moreover, different LEMs using different assumptions to solve the safety factors might include some amount orders of approximations. This study conducts probabilistic analyses, i.e., Monte Carlo simulations (MCSs) and uncertainty quantification, to obtain insights into the two LEMs applied to clay and sand slopes. The results reveal that the reliability indexes (RIs) obtained from the two LEMs-based MCSs are relatively identical for the same slope. Concerning the soil types, however, the RIs of the clay slope are significantly lower than those estimated for the sand slope, regardless of the LEMs used. The uncertainty quantifications for the clay slopes reveal that the two LEMs have relatively similar bias factors regarding FSs. Nevertheless, using the Fellenius method underestimates the probabilistic safety (about 17% in terms of the mean of FSs) for the sand slope compared to Bishop’s simplified method. Moreover, the coefficients of variation of FS obtained from the clay slope are consistently larger than those from the sand slope. These observations imply that the clay slope is more uncertain than the sand slope, and the Fellenius method results in lower FSs for sand slopes. Therefore, the FSs specified in the design codes should be connected to the soil type or the LEMs used to achieve the same probabilistic safety levels. Finally, the equivalent FSs associated with a RI of 1.75 are derived for each slope and each LEM used.
Association between severe acute malnutrition in childhood and hematological disorders in adulthood: the Lwiro follow-up study in the Eastern Democratic Republic of the Congo
Authors: Bedha Aline , Shindano Tony , Hermans Michel P. , Havelange Violaine , Makali Samuel , Minani Jimmy , Ngaboyeka Gaylord , Kunaba Edwige , Donnen Philippe , Dramaix Michelle , Bisimwa Ghislain , Mwene-Batu Pacifique 
Published: November 2023

Abstract
Background
Despite growing evidence on the short-term deleterious effects of severe acute malnutrition (SAM) in childhood on hematopoiesis, little is known about the long-term hematological effects of SAM in low-income countries (LICs). Our study explored the association between childhood SAM and hematological disorders in adults 11 to 30 years after post-SAM nutritional rehabilitation.

Methods
This follow up study investigated 97 adults (mean age 32 years) treated for SAM during childhood in eastern Democratic Republic of the Congo (DRC) between 1988 and 2007. Participants were compared to 97 aged- and sex-matched adult controls living in the same community with no history of SAM. Outcomes of interest were hematological characteristics and disorders in adulthood, assessed by various biological markers. Logistic and linear regression models were used to estimate the association between SAM in childhood and risk of hematological abnormalities.

Results
Compared to the unexposed, the exposed had higher mean white blood cells (/μl) [+ 840 (179 to 1501), p = 0.013], neutrophils [+ 504 (83 to 925), p = 0.019] and platelets (*103) [11.9 (8.1 to 17.9), p = 0.038] even after adjustment for food consumption in adulthood. No difference was observed in red blood cells (RBC), hemoglobin and erythrocytes parameters. With regard to the risk of hematological disorders, in contrast to the unexposed, exposed subjects had a risk of leukocytosis approximately three times higher [adjusted OR (95% CI): 2.98 (1.01 to 8.79), p = 0.048]. No difference was observed in terms of anemia, leukopenia, increased platelets and thrombocytopenia between the 2 groups.

Conclusion
Adults with a history of SAM in childhood have hematological characteristics that would be markers associated with chronic low-grade inflammatory or infectious diseases in an environment with no nutritional transition. Larger cohort studies with bone marrow analyses could provide further understanding of the impact of SAM on the overall hematological profile in adult life.
Predictors of endobronchial forceps utilization for inferior vena cava filter retrieval: when snare retrieval fails
Authors: Kang Richard D. , Schuchardt Philip , Charles Jonathan , Kumar Premsai , Drews Elena , Kazi Stephanie , DePalma Andres , Fang Adam , Raymond Aislynn , Davis Cliff , Massis Kamal , Hoots Glenn , Mhaskar Rahul , Nezami Nariman , Shaikh Jamil 
Published: November 2023

Abstract
Background
Endobronchial forceps are commonly used for complex IVC filter removal and after initial attempts at IVC filter retrieval with a snare have failed. Currently, there are no clear guidelines to help distinguish cases where primary removal should be attempted with standard snare technique or whether attempts at removal should directly be started with forceps. This study is aimed to identify clinical and imaging predictors of snare failure which necessitate conversion to endobronchial forceps.

Methods
Retrospective analysis of 543 patients who underwent IVC filter retrievals were performed at three large quaternary care centers from Jan 2015 to Jan 2022. Patient demographics and IVC filter characteristics on cross-sectional images (degree of tilt, hook embedment, and strut penetration, etc.) were reviewed. Binary multivariate logistic regression was used to identify predictors of IVC filter retrieval where snare retrieval would fail.

Results
Thirty seven percent of the patients (n = 203) necessitated utilization of endobronchial forceps. IVC filter hook embedment (OR:4.55; 95%CI: 1.74–11.87; p = 0.002) and strut penetration (OR: 56.46; 95% CI 20.2–157.7; p = 0.001) were predictors of snare failure. In contrast, total dwell time, BMI, and degree of filter tilt were not associated with snare failure. Intraprocedural conversion from snare to endobronchial forceps was significantly associated with increased contrast volume, radiation dose, and total procedure times (p < 0.05).

Conclusion
IVC filter hook embedment and strut penetration were predictors of snare retrieval failure. Intraprocedural conversion from snare to endobronchial forceps increased contrast volume, radiation dose, and total procedure time. When either hook embedment or strut penetration is present on pre-procedural cross-sectional images, IVC filter retrieval should be initiated using endobronchial forceps.

Level of evidence
Level 3, large multicenter retrospective cohort.
Association of ABCA1 gene with Coronary Artery Disease (CAD): an overview
Authors: Yadav Tanu , Yadav Arti , Jafri Asif , Swaroop Suchit 
Published: November 2023

Abstract
Background
This review is a summarized study on CAD, CVD, atherosclerosis, and its association with the ABCA1 gene. Only 13 clinical as well as epidemiological and peer-reviewed research papers published in the associated field were chosen for the review from out of 55 articles.

Main body
The research papers have been collected and studied from PubMed, Research Gate, and Google Scholar search engines. In the study, it has been found that GWAS, cell culture, and data-based studies were done to figure out the relationship of the ABCA1 gene with heart diseases. Blood samples were collected and diagnosed both biochemically and genetically to find out the lipid level and its functioning in the efflux of cholesterol and its effect and association with the ABCA1 gene, and with CAD researchers.

Conclusions
Dysregulation of DNA methylation can be re-expressed epigenetically. These studies of the ABCA1 gene and its polymorphic variants would help in future research studies and further can develop new drugs and methods the for treatment of heart disease and CAD.
Evaluation of new target structure and recognition for point cloud registration and coordinates transformation of China’s large double-span bridge
Authors: Deng Xiaojun , Wang Shaorui , Zhuang Yanghao , Fan Yonghui , Zhou Yin 
Published: November 2023

AbstractIn view of the limited precision of traditional point cloud registration methods in bridge engineering, as well as the lack of intuitive guidance for bridge construction control regarding relative coordinate relationships of point clouds, this study proposes a novel dual-purpose target for the total station and laser scanner, along with a corresponding algorithm. The scanning point cloud undergoes intensity filtering, clustering, planar denoising, contour extraction, centroid fitting, registration transformation, target recognition, registration, and coordinate transformation. Experimental results demonstrate that the proposed algorithm can accurately extract the centroid coordinates of the targets and effectively handle complex on-site conditions. The coordinate transformation achieves high precision, with an amplification error of only 2.1 mm at a distance of 500 m. The registration precision between planar and spherical targets is nearly identical, surpassing that of planar iterative and ICP algorithms. Application of the algorithm in the context of China’s large double-span steel-tube concrete arch bridge scenario. it was found that the maximum deviation of the radius of the main chord tube was 10.8 mm, the maximum deviation of the distance from the center of the main chord tube was 8.3 mm, the average length of the merging opening was 775.0 mm, the maximum lateral deviation of the merging opening was 9.6 mm, and the maximum deviation of the height of merging opening was 25.2 mm. The results showed that no additional restraining measures were needed, and the smooth jointing could be realized only under a suitable temperature. Comparison with measurements obtained from the TS60 total station exhibits a close match, with a verification error within 3.9 mm, thereby meeting the precision requirements for construction control.
Precocious Puberty in Hypothyroidism: Mini-Review of Van Wyk–Grumbach Syndrome
Authors: Fernandez-Gonzalez Sara Maria , Perez Vila Marina Maria , Prado-Carro Ana Maria 
Published: November 2023

Abstract
Severe hypothyroidism can affect a variety of organs and can develop atypical manifestations. Peripheral precocious puberty may be secondary to other endocrinological diseases, which must be taken into account in the differential diagnosis in order to avoid unnecessary additional tests. Van Wyk–Grumbach syndrome is an infrequent manifestation characterized by severe hypothyroidism and incomplete precocious puberty. Diagnosis is made by clinical and complementary tests, and the main treatment goal is to achieve euthyroidism through hormone replacement. Prognosis is good once the treatment is established. The aim of this study is to review the available literature about Van Wyk–Grumbach syndrome following the PRISMA statement, and to present the first clinical case published in Spain. We have included the articles published during the period from 1905 to week 40 of 2022. A total of 68 articles have been selected for study and analysis, within which there are 99 published clinical cases. Girls accounted for 92.1% of cases (median age at the diagnosis 8.5 years). Metrorrhagia was the most prevalent symptom, present in 80.5% of the girls. Abdominal ultrasound was performed in 93.3% of the girls and 97.8% of them had at least one ovarian cyst. All cases were treated with levothyroxine, responding satisfactorily after the first doses of treatment. To conclude, Van Wyk–Grumbach syndrome is characterized by severe hypothyroidism and incomplete precocious puberty, which is important to keep in mind in order to avoid complementary exams and unnecessary surgical interventions.