bluuebunny/crossref_metadata_2025_split huggingface dataset:
A single-center study on the comparison of short-term efficacy of robotic and laparoscopic radical resection of middle and low rectal cancer with Da Vinci (Xi)
Authors: Niu Luwei , Fu Wei , Fu Haixiao , Wang Kai , Li Tengteng , Song Jun , Zhang Xuan 
Published: November 2023

Abstract
OBJECTIVE Robotic minimally invasive surgery is an important trend in the development of contemporary surgical technology. However, due to the current clinical application of robotic surgery system is in the stage of development, its status in the surgical treatment of middle and low rectal cancer has not been confirmed. The aim of this study was to compare and analyze the clinical efficacy and functional results of da Vinci (Xi)-assisted and traditional laparoscopic surgery in the treatment of middle and low rectal cancer.
METHODS 82 patients with middle and low rectal cancer (tumor lower margin ≤ 10cm) were selected from the affiliated Hospital of Xuzhou Medical University from August 2020 to December 2020. According to the sequential principle, they were randomly divided into robot group (n = 41) and laparoscopy group (n = 41). Robot-assisted radical resection and laparoscopy-assisted radical resection of middle and low rectal cancer were performed respectively. The relevant clinical and functional indexes of the two groups were compared.
RESULTS There was no significant difference in preoperative data between the two groups (P > 0.05). All patients completed the operation successfully and no one was converted to open surgery. The circumferential incisal margin was negative in both groups, and the resected mesorectum was intact in robot group and laparoscopy group. Compared with the laparoscopy group, the average intraoperative blood loss (55.2 ±29.8mLvs.109.5 ±58.5ml), postoperative gastrointestinal function recovery time (38.8 ±11.2hvs.50.7± 13.3h), diet recovery time (2.6 ±0.8dvs.3.4 ±1.7d) and catheter removal time (3.3 ±1.4dvs.6.7±1.9d) in the robot group were significantly reduced. The number of lymph node dissection and the rate of sphincter preservation (55% vs.35%) were better than those in the laparoscopy group, but the operation time (239.8 ±29.6 6.2vs.14.6 vs. 141.1 ±18.5 min) and the average hospitalization cost in the laparoscopy group were higher than those in the laparoscopy group (81000 ±13000 yuan vs.52000 ±8000 yuan). There was no significant difference in the mode of operation, the length of specimen resection, postoperative pathology, the grade of integrity of total mesorectal resection, postoperative hospital stay and the incidence of postoperative complications between the two groups. In addition, we found that patients in the robot group had higher satisfaction with defecation function, voiding function and sexual function.
CONCLUSION Robotic and laparoscopic surgery for middle and low rectal cancer had comparable surgical safety and immediate postoperative outcomes, but robotic surgery was superior to conventional laparoscopic surgery in terms of the number of lymph nodes cleared, anal preservation rate, and postoperative recovery of gastrointestinal function for faecal, urinary, and sexual function preservation.
Biomass and energy potential of Erianthus arundinaceus and Saccharum spontaneum-derived novel sugarcane hybrids in rainfed environments
Authors: Meena Mintu Ram , Perumal Govindaraj , Raja Arun Kumar , Kandasamy Elayaraja , Appunu Chinnasamy , Kumar Ravinder , Chhabra Manohal Lal , Kulshreshtha Neeraj , Govind Hemaprabha 
Published: November 2023

Abstract
Background
Energy canes are viable feedstocks for biomass industries due to their high biomass production potential, lower susceptibility to insects and diseases, better ability to adapt to extreme conditions and clean bioenergy. Interspecific hybrids (ISH) and intergeneric hybrids (IGH) have great potential to meet the growing demand of biomass, biomass-derived energy and feedstock.
Results
In this study, two types of energy canes, Type I and Type II, derived from S. spontaneum and E. arundinaceous background were evaluated for high biomass, fiber and bioenergy potential under subtropical climate along with the check varieties Co 0238 and CoS 767. Out of 18 energy canes studied, six energy canes, viz., SBIEC11008 (204.15 t/ha), SBIEC11005 (192.93 t/ha), SBIEC13008 (201.26 t/ha), SBIEC13009 (196.58 t/ha), SBIEC13002 (170.15 t/ha), and SBIEC13007 (173.76 t/ha), consistently outperformed the check varieties under Type-I, whereas in type-II, SBIEC11004 (225.78 t/ha), SBIEC11006 (184.89 t/ha), and SBIEC14006 (184.73 t/ha) energy canes produced significantly higher biomass than commercial checks, indicating their superior potential for cogeneration. Estimated energy output from the energy canes (700–1300 GJ/ha/year) exceeded the range of co-varieties (400–500 GJ/ha/year) and energy utilization efficiency in plants and ratoon crops for energy canes viz., SBIEC11008 (3%, 1.97%), SBIEC14006 (1.93%, 2.4%), SBIEC11005 (1.7%, 1.9%), and SBIEC11001 (1.01%, 1.03%), was higher than best checks Co 0238 (0.77, 0.9%). Additionally, energy canes SBIEC 13001 (22.35%), SBIEC 11008 (22.50%), SBIEC 14006 (28.54%), SBIEC 11004 (30.17%) and SBIEC 11001 (27.03%) had higher fiber contents than the co-varieties (12.45%).
Conclusion
The study gives insight about the potential energy canes for higher biomass and energy value. These energy cane presents a vital option to meet the future demand of bioenergy, fiber and fodder for biomass due to their versatile capacity to grow easily under marginal lands without competing with cultivated land worldwide.
Improved Quantification of MicroPET/CT Imaging Using CT-derived Scaling Factors.
Authors: Nandi Ayon , Nakano Masayoshi , Brašić James Robert , Brinson Zabecca S. , Kitzmiller Kelly , Mathur Anil , Mohamed Mona , Roberts Joshua , Wong Dean F , Kuwabara Hiroto 
Published: November 2023

Abstract

Purpose
Combined micro-PET/CT scanners are widely employed to investigate models of brain disorders in rodents using PET-based coregistration. We examined if CT-based coregistration could improve estimates of brain dimensions and consequently estimates of nondisplaceable binding potential (BPND) in rodent PET studies.
Procedures
PET and CT scans were acquired on 5 female and 5 male CD-1 mice with PET and CT scans were acquired on 5 female and 5 male CD-1 mice with 3-[18F]fluoro-5-(2-pyridinylethynyl)benzonitrile ([18F]FPEB), a radiotracer for the metabotropic glutamate receptor subtype 5 (mGluR5). In the proposed PET/CT (PTCT) approach, the tracer-specific standard volume was dimension-customized to each animal using the scaling factors from CT-to-standard CT coregistration to simplify PET-to-standard PET coregistration (i.e., 3 CT- and 6 PET-derived parameters). For comparison, conventional PET-based coregistration was performed with 9 (PT9) or 12 (PT12) parameters. PET frames were transferred to the standard space by the three approaches (PTCT, PT9, and PT12) to obtain regional time-activity curves (TACs) and BPND in 14 standard volumes of interest (VOIs). Lastly, CT images of the animals were transferred to the standard space by CT-based parameters from PTCT and with the scaling factors replaced with those from PET-based PT9 to evaluate agreement of the skull to the standard CT.
Results
The PET-based approaches showed various degrees of underestimations of scaling factors in the posterior-anterior-direction compared to PTCT, which resulted in negatively proportional overestimation of radioactivity in the cerebellum (reference region) up to 20%, and proportional, more prominent underestimation of BPND in target regions down to -50%. The skulls of individual animals agreed with the standard skull for scaling factors from PTCT but not for the scaling factors from PT9, which suggested inaccuracy of the latter.
Conclusions
The results indicated that conventional PET-based coregistration approaches could yield biased estimates of BPND due to erroneous estimates of brain dimensions when applied to tracers for which the cerebellum serves as reference region. The proposed PTCT provides evidence of a quantitative improvement over PET-based approaches for brain studies using micro-PET/CT scanners.
Spatial distribution and quantification of plant-available nutrients and soil properties in Punjab, Pakistan
Authors: Rebi Ansa , Wang Guan , Hussain Azfar , Flynn Trevan , Ullah Haseen , Chenghao Zheng , Jamil Muhammad , Afzal Ali , khan Muhammad Umar Hayat , Ahmed Muhammad Ibrar , Zhou Jinxing 
Published: November 2023

Abstract
The quantification and spatial distribution of nutrients are crucial for agriculture production and protection. However, locally quantifying these soil variables is challenging in areas where transitions change over short distances, making correct land-use management difficult. This research paper aimed to quantify and analyze the spatial distribution of micronutrients (zinc, copper, iron, manganese and boron), macronutrients (potassium and phosphorus), as well as soil characteristics (electrical conductivity, pH, organic matter, and soil saturation) in the agricultural districts of Sahiwal and Sargodha in Punjab, Pakistan. The mean available phosphorus (AP) concentrations ranged from 7.37 to 7.00 mg/kg in Sahiwal and Sargodha, respectively, falling below the permissible range in both regions. Conversely, potassium (K) levels were within the recommended range, with values ranging from 110 to 280 mg/kg in Sahiwal but lower in Sargodha. Zinc (Zn) concentrations ranged from 1.6 to 0.4 mg/kg in Sahiwal and 1.8 to 0.3 mg/kg in Sargodha, with acceptable levels in Sahiwal but not in Sargodha. Copper (Cu) concentrations in both regions met acceptable standards. Mean iron (Fe) values were 5.6 and 5.2 mg/kg in Sahiwal and Sargodha, respectively, exceeding the limit in Sahiwal but falling below in Sargodha. Manganese (Mn) concentrations were acceptable in Sargodha but low in Sahiwal while boron (B) levels were below acceptable thresholds in several Sargodha samples but within limits in Sahiwal. Some Sahiwal samples exhibited excessively high pH, unlike in Sargodha. Nevertheless, both areas adhered to permissible soil saturation levels, except for one Sahiwal sample with elevated electrical conductivity (EC). Soil organic matter (SOM) content ranged from 0.57% to 0.52% in Sahiwal and Sargodha, respectively, with the majority of samples from both regions falling below permissible SOM ranges. The results suggest that quantity and spatial distribution are affected by locality, and therefore, exciting land-use management protocols should be adopted for spatial distribution and changes, not just absolute quantities. This study provides practical recommendations for farmers, researchers, and policymakers to enhance agricultural production and sustainability in Sahiwal and Sargodha.
Effectiveness of integrase strand transfer inhibitors among treatment-naive HIV-infected patients in China: A retrospective real-world study
Authors: Chen Mingyu , Liu Cong , Xie Jinzhao , Tang Xiaoping , Zhang Yao , Pan Deng , Zhong Haidan , Du Peishan , Li Quanmin , Li Linghua , Gu Jing , Cai Weiping 
Published: November 2023

Abstract
Background
Integrase strand transfer inhibitors (INSTIs) in anti-retroviral therapy (ART) have been recommended by the World Health Organization for their higher efficacy, favorable safety and tolerability. However, the clinical evidence supporting switching to INSTI-containing regimes in low-and-middle-income countries is limited, as few patients have access to these regimes. We aimed to assess the effectiveness of INSTI-containing regimens in real-world settings in China compared to government-provided free ART.
Method
We compared the short-term and long-term effectiveness between INSTI-containing regimens and free ART drugs provided by the Chinese government in four dimensions: viral suppression status, immune response, liver and kidney function, and AIDS-related diseases. To control baseline confounders, we used propensity score matching, calculated using logistic regression including sociodemographic and baseline factors.
Results
Among 12,836 patients initiating ART from 2012 to 2019, 673 (5.2%) used INSTI-containing regimens.
Compared with patients initiating ART with free drugs, patients initiating ART with INSTI-containing regimens were more likely to be older (43.26±14.87 vs. 36.43±12.19; p<0.001), not single (66.6% vs. 51.0%; p<0.001), infected with HIV through sexual behavior with an opposite-sex partner (50.7% vs. 42.2%; p<0.001), had a lower baseline CD4 cell count (50 cells/μL vs. 239 cells/μL; p<0.001), present more AIDS-related diseases and abnormal results of liver and kidney function, and had more TB infection.
For short-term effectiveness, patients initiating INSTI-containing regimens were more likely to achieve viral suppression (81.4% vs. 52.0%; p<0.001). The differences in immune response, liver and kidney function and AIDS-related diseases were not significant between the two groups. For long-term effectiveness, viral suppression rates were similar (87.96% vs. 84.59%; p=0.135), with no significant differences in immune response, liver and kidney function, or AIDS-related diseases.
Conclusions
Our study suggests that patients initiating ART with INSTI-containing regimens have worse physical status at baseline than patients starting with free ART drugs. Furthermore, we found better virological performances of INSTI-containing regimens in the short-term but not in the long-term due to a high rate of drug changes. Our findings have clinical implications and provide new evidence regarding the effectiveness of INSTI-containing regimes in LMICs.
Painless thyroiditis induced by pembrolizumab leading to depleted pituitary hypothyroidism: a case report and literature review
Authors: Chen Ruona , Zhang Yuqin , Dai Yimeng , Zhong Ming , Du Sina , Zhao Haiying , Li Wei 
Published: November 2023

Abstract

Introduction
Cases of hypothyroidism (referred to as hypothyroidism) induced by PD-1 inhibitor therapy are common in clinical practice, but cases of pituitary hypothyroidism induced by thyrotoxicosis have not been reported.
Case Report
We report a case of painless thyroiditis induced by the PD-1 inhibitor pablizumab in a patient with esophageal cancer with Hashimoto's disease combined with mild pituitary hypothyroidism, followed by depleting pituitary hypothyroidism induced by persistent severe thyroidal hypothyroidism.
Discussion/Conclusion
It is especially important to pay attention to the evolution of the disease in patients with pre-existing dual primary lesions, which are more complex.
Clinical efficacy analysis of preoperative endoscopic mucosal resection for non-ampullary lesions of the duodenum
Authors: wang jiaqi , shen shien , Hong Jiemin , Li Guomin , Shao xioana , yang Nuonan , shen jianwei 
Published: November 2023

Abstract
Background: With the continuous development of endoscopic technology, the detection rate of more and more non ampullary duodenal lesions (NADLs) in the duodenum is gradually increasing. Therefore, it was crucial to choose appropriate endoscopic techniques for the treatment of non ampullary lesions of the duodenum, this article aims to explore the selection of endoscopic treatment methods for lesions, in order to further improve its efficacy and safety, and improve the quality of life of patients.
Method and Results: A retrospective analysis was conducted on the clinical data of 100 patients diagnosed with non ampullary duodenal lesions in the Li Huili East Hospital and Yinzhou Second Hospital of Ningbo Medical Center from May 2015 to May 2023.All patients successfully completed endoscopic resection with a total resection rate of 100.0% and an overall R0 resection rate of 96.0%,for further research, we conducted a detailed analysis of lesions with a size of 10-20mm, including 55 patients, including 22 in the EMR group, 15 in the Pre-cut-EMR group, and 18 in the ESD group, the study showed that the surgery time in the EMR and Pre-cut-EMR groups was shorter than that in the ESD group, but the R0 resection rate in the EMR group was lower than that in the Pre-cut-EMR and ESD groups, the average length of hospital stay and average hospital expenses in the EMR group and Pre-cut-EMR group were significantly lower than those in the ESD group, and the difference was statistically significant (P<0.05).
Conclusion: The R0 resection rate of EMR in lesions with a size of 10-20mm was relatively low, making it impossible to completely resect at once, resulting in a high probability of intraoperative residual and high postoperative risk; Pre-cut-EMR, as a new technology, had a higher R0 resection rate compared to EMR, with ESD, Pre-cut-EMR had lower surgical difficulty, shorter surgical time, higher safety performance, and lower incidence of complications.
MrgprA3 neurons selectively control myeloid-derived cytokines for IL-17 dependent cutaneous immunity.
Authors: Herbert De'Broski , Inclan-Rico Juan , Napuri Camila , Lin Cailu , Hung Li , Ferguson Annabel , Wu Qinxue , Pastore Christopher , Stephenson Adriana , Femoe Ulrich , Rossi Heather , Reed Danielle , Luo Wenqin , Abdus-Saboor Ishmail 
Published: November 2023

Abstract

Skin employs interdependent cellular networks to facilitate barrier integrity and host immunity through ill-defined mechanisms. This study demonstrates that manipulation of itch-sensing neurons bearing the Mas-related G protein-coupled receptor A3 (MrgprA3) drives IL-17+ γδ T cell expansion, epidermal thickening, and resistance to the human pathogen Schistosoma mansoni through mechanisms that require myeloid antigen presenting cells (APC). Activated MrgprA3 neurons instruct myeloid APCs to downregulate interleukin 33 (IL-33) and up-regulate TNFα partially through the neuropeptide calcitonin gene related peptide (CGRP). Strikingly, cell-intrinsic deletion of IL-33 in myeloid APC basally alters chromatin accessibility at inflammatory cytokine loci and promotes IL-17/23-dependent epidermal thickening, keratinocyte hyperplasia, and resistance to helminth infection. Our findings reveal a previously undescribed mechanism of intercellular cross-talk wherein “itch” neuron activation reshapes myeloid cytokine expression patterns to alter skin composition for cutaneous immunity against invasive pathogens.
How Urban Form Impacts Flooding
Authors: Qomi Mohammad Javad Abdolhosseini Abdolhosseini , Balaian Sarah , Sanders Brett 
Published: November 2023

Abstract

Urbanization and climate change are contributing to severe flooding globally, damaging infrastructure, disrupting economies, and undermining human well-being. Approaches to make cities more resilient to floods are emerging, notably with the design of flood-resilient structures, but relatively little is known about the role of urban form and its complexity in the concentration of flooding. We leverage statistical mechanics to reduce the complexity of urban flooding and develop a mean-flow theory that relates flood hazards to urban form characterized by the ground slope, urban porosity, and the Mermin order parameter which measures symmetry in building arrangements. The mean-flow theory presents a dimensionless flood depth that scales linearly with the urban porosity and the order parameter, with different scaling for disordered square- and hexagon-like forms. A universal scaling is obtained by introducing an effective mean chord length representative of the unobstructed downslope travel distance for flood water, yielding an analytical model for neighborhood-scale flood hazards globally. The proposed mean-flow theory is applied to probe city-to-city variations in flood hazards, and shows promising results linking recorded flood losses to urban form and observed rainfall extremes.
Validation of a Chinese Positive Youth Development Scale: Dimensionality and Factorial Invariance
Authors: Zhu Xiaoqin , Chu Carman K.M. , Wu Xue , Shek Daniel T.L. 
Published: November 2023

Abstract

For a multi-dimensional measure of positive youth development (PYD), its factor structure should be invariant across groups and over time. This study examined the factorial validity of the 44-item short form of the “Chinese Positive Youth Development Scale” (CPYDS-SF) that assesses 15 dimensions of PYD attributes. Using two waves of longitudinal data with a one-year interval in between, this study examined the factor structure of the scale and whether the structure is invariant between gender groups and across time. The data were collected from 3,328 adolescents at Wave 1 and 3,638 adolescents at Wave 2, with a matched sample of 2,905 adolescents (mean age = 12.57 ± 0.72 at Wave 1; 49.54% girls). Confirmatory factor analysis revealed that the 15-factor structure fitted the data well. The findings of invariance tests further supported this structure’s invariance across gender and time, indicating a stable factor structure of CPYDS-SF among Chinese adolescents. These findings suggest that CPYDS-SF can be used to examine gender differences and the longitudinal development of PYD qualities among Chinese adolescents.
Insulin-like Growth Factor Binding Protein 2 in Severe Aortic Valve Stenosis and Pulmonary Hypertension: A Gender-Based Perspective
Authors: Boxhammer Elke , Paar Vera , Kopp Kristen , Kletzer Joseph , Bovenkamp-Aberger Evelyn , Rezar Richard , Lichtenauer Michael , Hoppe Uta , Mirna Moritz 
Published: November 2023

Abstract

Background
Severe aortic valve stenosis (AS) and pulmonary hypertension (PH) are life-threatening cardiovascular conditions, necessitating early detection and intervention. Recent studies have explored the role of Insulin-like Growth Factor Binding Protein 2 (IGF-BP2) in cardiovascular pathophysiology. Understanding its involvement may offer novel insights into disease mechanisms and therapeutic targets for these conditions.
Material & Methods
102 patients (46 female, 56 male) with severe AS undergoing transcatheter aortic valve replacement (TAVR) in a single-center study were classified using echocardiography to determine systolic pulmonary artery pressure (sPAP) and the presence (sPAP ≥ 40 mmHg) or absence (sPAP < 40 mmHg) of PH. Additionally, serial laboratory determinations of IGF-BP2 before, and at 24 hours, 96 hours, and 3 months after intervention were conducted in all study participants.
Results & Discussion
Considering the entire cohort, patients with PH had significant and continuously higher serum IGF-BP2 concentrations over time than the cohort without PH. After subdivision by sex, it could be demonstrated that above-mentioned results were only verifiable in male, but not in female sex. In the male sex, baseline IGF-BP2 before TAVR was an isolated risk factor for premature death after intervention and at 1, 3 and 5 years post intervention. The same was valid for the combination of male sex and echocardiographically established PH.
Conclusion
The predictive role of IGF-BP2 in severe AS and concurrent PH remains unknown. A more profound comprehension of IGF-BP2 mechanisms, particularly in males, could facilitate earlier consideration of TAVR as a more effective and successful treatment strategy.