bluuebunny/crossref_metadata_2025_split huggingface dataset:
L'innovation par le verbe et l'image
Authors: Boyer Frédéric , Novarina Valère , Sarthou-Lajus Nathalie , Euvé François 
Published: December 2023

Il existe un lien privilégié entre Les Écritures et l’écriture, entre le christianisme, la littérature et la poésie. En régime chrétien, La Nouvelle traduction de la Bible (Bayard 2001) est le dernier chantier d’envergure innovateur d’un point de vue biblique et littéraire. Comment ce travail a-t-il contribué à féconder les œuvres d’une génération d’écrivains comme Valère Novarina et Frédéric Boyer ? Une nouvelle vitalité du christianisme peut-elle advenir du côté de la littérature contemporaine ?
Vers une Église « liquide »
Authors: Join-Lambert Arnaud 
Published: December 2023

Les mutations du rapport entre l’Église et la société mettent en question le modèle traditionnel de la paroisse. Des essais de nouvelles paroisses sont tentés. L’hypothèse est d’appliquer aux communautés chrétiennes le qualificatif de « liquide » emprunté au sociologue Zygmunt Bauman. Cela permettrait de retisser les liens entre les communautés chrétiennes et l’ensemble de la société.
Surmonter le chômage de longue durée
Authors: Soulage François 
Published: December 2023

Dans une France qui compte actuellement 3 500 000 chômeurs de catégorie A, c’est-à-dire n’ayant pas occupé un emploi au cours du mois précédent, et 5 400 000 personnes qui n’ont pas travaillé ou ont travaillé moins de 75 heures dans le mois précédent, le chômage de longue durée est un véritable fléau. C’est pourquoi on pouvait penser que le gouvernement en ferait un enjeu prioritaire.
Le coaching, un symptôme de fragilité du lien social
Authors: Le Coz Pierre 
Published: December 2023

On a longtemps voulu y voir un simple phénomène de mode. Mais, aujourd’hui, il faut se rendre à l’évidence : le coaching a pris racine dans notre culture. En l’espace de trois décennies, il s’est émancipé de son contexte sportif d’origine pour s’étendre à l’ensemble du monde professionnel.
NADPH Oxidase 2–Derived Reactive Oxygen Species Promote CD8+ T Cell Effector Function
Authors: Chen Jing , Liu Chao , Chernatynskaya Anna V , Newby Brittney , Brusko Todd M , Xu Yuan , Barra Jessie M , Morgan Nadine , Santarlas Christopher , Reeves Westley H , Tse Hubert M , Leiding Jennifer W , Mathews Clayton E 
Published: December 2023

Abstract
Oxidants participate in lymphocyte activation and function. We previously demonstrated that eliminating the activity of NADPH oxidase 2 (NOX2) significantly impaired the effectiveness of autoreactive CD8+ CTLs. However, the molecular mechanisms impacting CD8+ T cell function remain unknown. In the present study, we examined the role of NOX2 in both NOD mouse and human CD8+ T cell function. Genetic ablation or chemical inhibition of NOX2 in CD8+ T cells significantly suppressed activation-induced expression of the transcription factor T-bet, the master transcription factor of the Tc1 cell lineage, and T-bet target effector genes such as IFN-γ and granzyme B. Inhibition of NOX2 in both human and mouse CD8+ T cells prevented target cell lysis. We identified that superoxide generated by NOX2 must be converted into hydrogen peroxide to transduce the redox signal in CD8+ T cells. Furthermore, we show that NOX2-generated oxidants deactivate the tumor suppressor complex leading to activation of RheB and subsequently mTOR complex 1. These results indicate that NOX2 plays a nonredundant role in TCR-mediated CD8+ T cell effector function.
Emergency Skills in Athletic Training: Perceived Knowledge and Continuing Education
Authors: Gerlach Brian , Jochum Jessica , Salamh Paul , Moore Elizabeth S. 
Published: December 2023

Context
Continuing education (CE) in health care, particularly in athletic training, often fails to meet the needs of its participants. Rapid increases in available information make it necessary for CE to be delivered as efficiently as possible.

Objective
To explore whether an interactive teaching strategy and various characteristics of athletic trainers affected the perceived knowledge of emergency skills among certified athletic trainers.

Design
Quasiexperimental study with a single-group pretest-posttest design.

Patients or Other Participants
Certified athletic trainers (N = 81) at the Great Lakes Athletic Trainers' Association Annual Meeting and Symposium.

Intervention(s)
Emergency skills practice session for anaphylaxis, opioid overdose, diabetes, and asthma.

Main Outcome Measure(s)
Participants completed a preintervention perceived knowledge questionnaire (PKQ) that included background information questions and completed a postintervention PKQ.

Results
A statistically significant difference (P &lt; .001) in PKQ scores from pretest to posttest was found with pretest scores being lower than posttest scores (89.59 and 103.02, respectively). Age and years of experience had a weak correlation with PKQ pretest scores (rs = .32 and rs = .33, respectively). Participant characteristics including additional certification (P = .012), anaphylaxis experience (P = .036), opioid overdose experience (P &lt; .001), diabetes experience (P = .025), and combined emergency experience (P = .029) had significantly different pretest PKQ scores.

Conclusions
The use of an interactive teaching strategy in CE and certain athletic trainer characteristics significantly affected athletic trainers' perceived knowledge of emergency skills.
Predictors of hemorrhagic manifestations in dengue: A prospective observational study from the Hadoti region of Rajasthan
Authors: Jelia Shiv Charan , Ajmera Devendra , Airan Divya , Bairwa Ranjeet , Meena Yogesh 
Published: December 2023

Objective:
To study the laboratory and clinical predictors of hemorrhagic manifestations in dengue virus-infected patients.

Methods:
This was a single-center hospital-based prospective observational study. 200 Dengue seropositive patients were included in the study. A detailed clinical examination was done and comprehensive laboratory investigations were done. These parameters were compared between patients with and without hemorrhagic manifestations.

Results:
Out of the 200 patients, 47 (23.5%) had bleeding. 64.5% Patients were males and 76.0% were under the age of 40 years. The most common presenting symptoms were fever (100.0%) followed by myalgia (77.0%), nausea and vomiting (56.0%). Leukocytosis, neutrophilia, thrombocytopenia, hyperbilirubinemia, transaminitis, decreased serum albumins, and raised D-dimer can serve as hematological, biochemical, and coagulation predictors of hemorrhagic manifestations for dengue.

Conclusions:
Dengue is a tropical infection with various complications. Bleeding complications are one of them. Laboratory parameters like white blood cells, platelets, bilirubin level, liver enzymes, and D-dimer can help to identify patients at risk for bleeding. Early identification and appropriate management can save a lot of resources and lives.
Clinical profile of medication-related emergencies among patients presenting to the emergency department: An observational study
Authors: Yagadi Srilatha , Guguloth Ramesh Babu , Jacob Mathews 
Published: December 2023

Objective:
To determine the clinical profile of patients presenting with medication-related emergencies to the Emergency Department of our institute.

Methods:
This was an observational study conducted between November 2018 and September 2020 at Bangalore Baptist Hospital, Karnataka. A total of 138 subjects who satisfied the inclusion criteria were included in the study. The severity of adverse drug reactions (ADR) is assessed based on the Hurwitz severity assessment scale of ADR. Glasgow coma scale at the time of presentation and source of medication were noted. The type of drug overdose, requirement of advanced airway and vasopressors, and the outcome were also assessed.

Results:
Among medication-related emergencies (n=138) in our study, ADR contributed to 70.3% (n=97) of the study population, and drug overdose accounted for 29.7% (n=41). One-third of the ADR occurred in patients aged above 60 years. Most patients were hemodynamically stable and did not require vasopressors, or advanced airway in both groups. Most patients had Glasgow coma scale ranging from 13-15 in both groups. Nonsteroidal anti-inflammatory drugs were the most used medicine (17/41, 41.5%) and most medications were over the counter drugs (25/41, 61.0%) in the drug overdose group; meanwhile in the ADR group, anti-diabetic medication was the most used medicine (34/97, 35.1%) and most medications were prescribed in the ADR group (93/97, 95.9%).

Conclusions:
Our study shows that ADR is the most common type of medication-related emergency.
Epidemiological characteristics and trends of animal bites in Neyshabur, Iran: A cross-sectional study
Authors: Shariat Mansoore Sarcheshme , Esmaeilzadeh Nayereh , Zerangian Nasibeh , Peyman Nooshin 
Published: December 2023

Objective:
To investigate the trend of animal bites between 2015-2021 in Neyshabur, Iran.

Methods:
In this cross-sectional descriptive study, data were retrieved from the vice-chancellery of the Neyshabur University of Medical Sciences. The data included person variables, place and time variables, and animal variables.

Results:
There were 13190 cases of animal bites and the trend was increasing during 2015-2020. Most injuries were caused by dogs (86%), most animal bites (76.6%) occurred in males, and 28.1% of all cases were farmers. The most common bitten parts were the lower limbs (64.8%), often reported as a scratch (83.4%). Most of the biting animals (67.9%) were not strays, and 83.3% of them had bitten their owners. No rabies death was reported during the study period.

Conclusions:
The incidence of animal bites increases and is higher than the national statistics in Neyshabur, Iran. Serious attention and intervention should be given to control and prevent this health threat.
Cryopreserved ovine spermatogonial stem cells maintain stemness and colony forming ability in vitro
Authors: Pramod R. Kumar , Varughese Deepthi , Jameel A. Javed , Panda Bhisma Narayan , Goswami Soma , Mitra Abhijit 
Published: December 2023

Objective:
To assess the effect of cryopreservation on stemness and proliferation potential of sheep spermatogonial stem cells (SSCs) in vitro.

Methods:
Sheep testicular cells were isolated and putative SSCs were enriched by the laminin-based differential plating method. Putative SSCs were co-cultured with the Sertoli cell feeder prepared by the Datura Stramonium Agglutinin (DSA-lectin)-based method. The cultured putative SSCs were cryopreserved in Dulbecco's Modified Eagle Medium-10% fetal bovine serum mixture (DMEM-10% FBS) media containing 10% dimethyl sulfoxide (DMSO) alone or 10% DMSO plus 200 mM trehalose. Cryopreserved putative SSCs were evaluated for their proliferation potential using in vitro culture and stemness by immunocytochemistry. Finally, the transfection ability of cryopreserved putative SSCs was analyzed.

Results:
We isolated 91% viable testicular cells from sheep testes. The majority of the laminin enriched cells expressed the SSC related marker, ITGA6. Co-culture of sheep putative SSCs with Sertoli cell feeder resulted in the generation of stable colonies, and the expression of SSC marker was maintained after several passages. A significantly higher number of viable putative SSCs was recovered from SSCs cryopreserved in media containing 10% DMSO and 200 mM trehalose compared to 10% DMSO alone (P<0.01). Cryopreserved putative SSCs formed colonies and showed SSC marker expression similar to the non-cryopreserved putative SSCs. The appearance of green fluorescent colonies over the Sertoli cell feeder indicated that cryopreserved sheep SSCs were successfully transfected.

Conclusions:
Cryopreserved putative SSCs can retain their stemness, colony forming ability, and transfection efficiency in vitro. Our research may help in the effective preservation of germplasm and the generation of transgenic ovine species.
Seasonal stress on semen quality profiles, seminal biochemical and oxidative stress attributes in endangered Teressa goat of Andaman and Nicobar Islands
Authors: Perumal P. , Sunder Jai , De A. K. , Bhattacharya D. , Nahak A. K. , Vikram R. , Chakurkar E. B. 
Published: December 2023

Objective:
To measure seasonal effects on semen quality profiles, seminal biochemical and oxidative stress attributes in fresh and liquid stored semen in monsoon and dry seasons.

Methods:
A total of 10 Teressa bucks (3-4 years) were selected from breeding farm, ICAR-Central Island Agricultural Research Institute, Port Blair, Andaman and Nicobar Islands, India. Semen samples (n=25 per season) were collected through artificial vagina method and preserved at refrigerated temperature (5°C) for 48 h using Tris citrate glucose based extender. We detected semen quality parameters [volume, mass activity, pH, sperm concentration, total motility, viability, total sperm abnormality, and plasma membrane, acrosomal and nuclear integrities], biochemical profiles [aspartate amino transferase (AST), alanine amino transferase (ALT) and total cholesterol], and oxidative stress markers [total antioxidant capacity (TAC) and malondialdehyde (MDA)] during monsoon and dry seasons.

Results:
Semen quality parameters significantly differed between seasons (P<0.05) and among storage periods (P<0.05). Volume, pH, mass activity, motility, viability, acrosomal, plasma membrane and nuclear integrities, and TAC were significantly higher (P<0.05). Sperm concentration, sperm abnormalities, MDA, AST, ALT and total cholesterol were significantly lower in fresh semen of monsoon than dry season (P<0.05). Motility, viability, acrosomal, plasma membrane and nuclear integrities, and TAC were significantly decreased (P<0.05) while sperm abnormality, AST, ALT, total cholesterol and MDA were significantly increased as liquid semen storage period advanced (P<0.05).

Conclusions:
Monsoon season has higher beneficial effects on semen quality profiles and liquid stored semen remained usable for upto 48 h. Good quality ejaculates with higher TAC and lower MDA can be cryopreserved and will be used for artificial insemination.
Impact of Anterior Commissure Involvement and Frozen Guided Resections on Oncological Outcomes after Laser Cordectomy in Early Glottic Cancers – A 10-year Retrospective Analysis from a Tertiary Care Cancer Center in India
Authors: Iype Elizabeth Mathew , Vishwani Ankit , Varghese Bipin T , Thomas Shaji , Lal Sahya S 
Published: December 2023

Background:
Early glottic cancers can be treated using different options such as transoral laser microsurgery (TLM), open partial laryngectomy (OPL), and radiation therapy (RT). TLM provides similar oncological benefits to OPL in a few subsets of patients, and the quality of voice is comparable to RT, while hospitalization time is reduced. Resection by laser microsurgery of early glottic cancer with anterior commissure involvement (ACI) is more challenging mainly due to difficulty in adequate exposure. The frozen section is reliable in TLM for determining the extent of resection and the real depth which may be masked on videoscopy.

Materials and Methods:
This study is a retrospective analysis of patients with early glottic cancer (Tis, T1) who underwent TLM in a tertiary cancer center in South India from January 1, 2012, to December 31, 2019. All patients were identified from the hospital registry.

Results:
The study included 89 patients, and the median follow-up was 54 months. Out of 89 patients, 14 patients had local recurrence which was managed with salvage TLM/salvage RT/salvage laryngectomy. There were three patients with nondisease-specific deaths. Among the study population, the laryngeal preservation rate was 96.6%, the cause-specific survival rate was 100%, and the overall survival rate was 97.7%. The 3-year disease-free survival rate was 84.4%. ACI and frozen margin positivity were statistically significant poor prognostic factors.

Conclusion:
TLM is a safe and effective treatment of early glottic carcinoma. Apart from tumor (T) staging, ACI and frozen positivity were negative predictive factors. The results suggest the need to consider ACI in the T staging of glottic tumors. Frozen positivity helps us in re-excision but signifies that the disease is deeply infiltrative or aggressive and a vigilant follow-up is required for these patients.
Tooth Movement in Immune System
Authors: Ramadayanti Sonya L. , Caesar Aya D. O. , Amalia Reniyanti , Warizgo Diyan R. , Ardani I Gusti Aju Wahju 
Published: December 2023

Aim:
Applying forces to teeth causes orthodontic tooth movement. Orthodontic tooth movement necessitates bone remodeling, brought on by intricate aseptic inflammatory cellular and molecular processes. According to the “pressure-tension” theory, applying pressure to a tooth varies the blood vessels' diameter in the periodontal ligament, which then changes the blood flow. Chemical messengers cause cellular changes as a result, which results in the remodeling of the alveolar bone.

Materials and Methods:
This study was obtained based on literature in journals from Pubmed, Scopus, and Web of Science databases. The review developed a method to determine whether comparable the literature was using the exact keywords before developing findings and then summarizing them into a continuous sequence. The case reports investigated patients who met the inclusion criteria for dental implants and osseointegration. There were 21 journals from PubMed, Scopus, and Web of Science databases. The present review is from research, review, and case report study with eligibility criteria. The review results discovered that according to the “pressure-tension” idea, applying pressure to a tooth modifies the blood flow by altering the periodontal ligament's blood vessel diameter.

Results:
Alveolar bone remodeling results from cellular changes brought on by chemical messengers. Inflammation is the host tissue's defensive reaction to pathogens, injury, or external objects. Vascular dilation, improved capillary permeability, increased blood flow, and leukocyte recruitment are all signs of inflammation. The first cells to arrive at the inflamed region are polymorphonuclear neutrophils. Eicosanoids, a group of hormones that includes prostaglandins, are chemical messengers.

Conclusion:
Several articles have suggested specific compounds as orthodontic tooth movement biomarkers. The creation of biomarkers to comprehend the ongoing biological processes related to orthodontic tooth movement is developing.
Association Between Parental Migration and Dental Caries of 3-12-Year-Old Children in China
Authors: Liu Sichen , Thearmontree Angkana , Chongsuvivatwong Virasakdi , Zhang Shinan , Zhang Limei 
Published: December 2023

Aim:
This review sought to examine the prevalence of dental caries in left-behind children (LBC) and explore the association between parental migration and dental caries among children in China.

Materials and Methods:
Web of Science, PubMed, the China National Knowledge Infrastructure, Weipu, and Wanfang were searched about the LBC and dental caries in China from 2000 to May 2021. The primary outcome was the prevalence of dental caries in primary and permanent dentition among LBC. The number of children with dental caries among LBC and non-LBC (NLBC) was pooled, and the odds ratio (OR) and 95% confidence intervals (CI) of the relationship between parental migration and children's dental caries were determined.

Result:
These included a total sample of 8275 children aged 3–12 years from a total of 11 studies, of which 4547 were LBC and 3728 were NLBC. The pooled prevalence of dental caries among Chinese LBC aged 3–12 years was 64%. Parental migration was significantly associated with the prevalence of dental caries. LBC has a 1.61 times higher risk of having dental caries than NLBC (95% CI: 1.47–1.77). LBC living in the countryside has a higher prevalence (68%) and higher risk of developing dental caries (OR = 1.64; 95% CI: 1.48–1.82) than those living in the city. The prevalence of dental caries is notably elevated among LBC in China.

Conclusion:
Parental migration stands out as a significant risk factor for dental caries in children aged 3–12 years, particularly in rural or countryside regions. The results call attention to the oral health problems among the LBC.
Persistent Hyperglycemia Worsens the Oleic Acid Induced Acute Lung Injury in Rat Model of Type II Diabetes Mellitus
Authors: Yadav Rinkoo , Kailashiya Vikas , Sharma Hanjabam B. , Pandey Ratna , Bhagat Priyanka 
Published: December 2023

Aim:
This research aimed to study the impacts of persistent hyperglycemia on oleic acid (OA)–induced acute lung injury (ALI) in a rat model of type II diabetes mellitus.

Materials and Methods:
Healthy adult male albino rats that weigh 150 to 180 g were divided into four groups (n = 6). Group I-saline (75 μL i.v.) was injected and served as a control; group II-OA (75 μL i.v.) was injected to induce ALI. Group III-pretreated with a high-fat diet and streptozotocin (35 mg/kg), was injected with saline, and served as a control for group IV. Group IV was pretreated with a high-fat diet, and streptozotocin (35 mg/kg) was injected with OA (75 μL i.v). Urethane was used to anesthetize the animal. The jugular venous cannulation was done for drug/saline administration, carotid artery cannulation was done to record blood pressure, and the tracheal cannulation was done to maintain the respiratory tract’s patent. Heart rate, mean arterial pressure, and respiratory frequency were recorded on a computerized chart recorder; an arterial blood sample was collected to measure PaO2/FiO2. Additionally, the pulmonary water content and lung histology were examined.

Result:
Hyperglycemic rats showed no significant change in the cardio-respiratory parameter. Histology of the lungs shows fibroblastic proliferation; however, rats survived throughout the observation period. There was an early deterioration of all the cardio-respiratory parameters in hyperglycemic rats when induced ALI (OA- induced), and survival time was significantly less compared to nonhyperglycemic rats.

Conclusion:
Persistent hyperglycemia may cause morphological changes in the lungs, which worsens the outcome of acute lung injury.