bluuebunny/crossref_metadata_2025_split huggingface dataset:
A Systematic Review on Effect of Scoparia Dulcis on Alterations in Antioxidant Status, Oxidative Damage in Diabetes and Other Pharmacological Activities
Authors: Murugan Pidaran 
Published: February 2024

Oxidative stress is implicated in the pathogenesis of diabetic complications. Diabetes mellitus is presently a burden not only on the individuals affected by the disease but also on society, particularly the national health system of all the countries. The war against diabetes through the development of new drugs is an ongoing continuous process. Despite many advances in the development of oral hypoglycemic agents, an ideal drug for treating diabetes mellitus is still a distant reality. As pointed out by World Health Organisation (WHO), prevention of diabetes and its complications is not only a major challenge for the future, but essential if health for all is to be attainable target. WHO study groups emphasize strongly in this regard the optimal, rational uses of traditional and natural indigenous medicine. The study of such medicinal plants might offer a natural key to unlock diabetologists pharmacy for the future. Indian traditional medicines have a long history to treat diabetic mellitus (DM) by the herbs and herbal extracts. Scoparia dulcis, also known as sweet broom weed, is a perennial herb which is commonly found in tropical and subtropical regions. In these regions, the fresh or dried plant has traditionally been used as one of remedies for diabetes and various diseases. The plant is abundantly found in many countries and can be easily grown and cultivated, should there be a need for mass production. The whole plant is used for ailments like diarrhea, stomach-ache, kidney stones, kidney problems, and fever. S. dulcis is a rich source of flavones, terpenes and steroids S. dulcis is one of the traditional antidiabetic herbs. There were so many research work done on its antidiabetic properties. S. dulcis has been used by human for centuries as a medicinal herb. S. dulcis has also been shown to exhibit analgesic, antimalarial, hepatoprotective, sedative, hypnotic, antiulcer, antisickling, and antimicrobial activities. Given this evidence, it may be concluded that S. dulcis could be promoted among the masses as an alternative and complementary therapy for diabetes, provided further scientific studies on the toxicological and pharmacological aspects are carried out through either in vivo or clinical means.
Pediatricians’ Career Satisfaction and Wellbeing by Sex Before and During the COVID-19 Pandemic
Authors: Frintner Mary Pat , Leslie Laurel K. , Gottschlich Elizabeth A. , Starmer Amy J. , Byrne Bobbi J. , Freed Gary L. 
Published: February 2024

OBJECTIVE
To compare pediatrician career satisfaction and wellbeing by sex during the coronavirus disease 2019 pandemic with prepandemic years using longitudinal survey data.

METHODS
Data from a cohort study, the American Academy of Pediatrics Pediatrician Life and Career Experience Study, were used to examine career satisfaction and wellbeing from 2012 to 2021 among 2002–2004 and 2009–2011 residency graduates (n = 1760). Mixed effects logistic regression, including key pediatrician characteristics, examined career satisfaction and wellbeing measures for sex (female vs male), pandemic year (2012–2019 vs 2020–2021), and their interaction effect. Adjusted predicted percentage values (PVs) were determined.

RESULTS
In total, 73.4% of participants identified as female. Adjusting for key pediatrician characteristics, differences were found by sex for satisfaction and 4 of 5 wellbeing measures, by pandemic year for 2 wellbeing measures, and the interaction of sex and pandemic year for 3 wellbeing measures. Female pediatricians reported higher levels of anxiety, sadness, and work stress, with greater differences during the pandemic. For example, female pediatricians (PV = 22.6, confidence interval [CI] = 21.0–24.3) were more likely than male pediatricians (PV = 14.2, CI = 12.0–16.4) to report anxiety during pre-pandemic years, and the difference between female pediatricians (PV = 29.3, CI = 26.7–32.0) and male pediatricians (PV = 12.4, CI = 9.3–15.5) increased during pandemic years (sex by pandemic year interaction, P &lt; .001).

CONCLUSIONS
Compared with male pediatricians, female pediatricians reported worse anxiety, sadness, and stress at work, and the differences were more pronounced during the pandemic.
Comparative Analysis of Dental Stem Cells from a Single Donor: Differences in Adipogenic Differentiation and Protein Profile
Authors: Marín-Uc José A. , Aguilar-Hernández Víctor , Hernández-Sotomayor Teresa , Brito Argáez Ligia , Nic-Can Geovanny I. , Chuc-Gamboa Martha Gabriela , Aguilar-Ayala Fernando , Aguilar-Pérez Fernando , Rodas-Junco Beatriz A. 
Published: February 2024

Dental stem cells (DSCs) are multipotent cells with high proliferation capacity and multilineage differentiation. Few studies have compared the cellular characteristics and adipogenic differentiation potential of DSCs derived from tissues of the same individual. The objective of this work was to evaluate the differences in growth characteristics, expression of mesenchymal stem cells (MSCs)-specific markers,
and the proteomic profile in response to adipogenic differentiation, of dental pulp and periodontal ligament cells obtained from a single donor. Dental cells were isolated from the third molar of a single donor using the outgrowth method. To obtain the proliferation curve of the cells was evaluated by trypan blue analysis. After the cells were cultured in adipogenic medium, morphological changes were monitored by oil red O staining, as well as adipogenic markers PPARγ and adiponectin by RT-qPCR. Finally, a two-dimensional electrophoresis of the proteins isolated from these cells was performed to analyze the proteomic profile. The two types of DSCs share similar cellular characteristics; however, their capacity for adipogenic differentiation is different. Based on the protein profiling results, we identified five differentially expressed proteins between both types of stem cells. Our findings showed that dental pulp and periodontal ligament stem cells from a single donor have similar cellular characteristics but a different response to adipogenesis, which would explain the differences in the expression of their proteins.
STEP analysis of macro-environmental factors affecting medical and drug care for patients with chronic myeloid leukemia
Authors: Zhuravlev A. V. , Knysh O. I. 
Published: February 2024

Objective: to conduct a STEP analysis (social, technological, economic, political) of macro-environmental factors influencing medical and drug care for patients with chronic myeloid leukemia (CML).Material and methods. The materials used were information from the official website of the Federal State Statistics Service of the Russian Federation (RF), financial reports of the Ministry of Finance of the RF, the Ministry of Industry of the RF, the Federal Customs Service of the RF, the Federal Treasury, the All-Russian Center for the Study of Public Opinion, data from the World Health Organization and the Ministry of Health of the RF, regulatory framework of the RF, data from the State Register of Medicines of the RF and information from domestic and foreign scientific publications. The object of the study was the Department of Hematology and Chemotherapy of the Regional Clinical Hospital No. 1 (Tyumen). Structural, statistical, analytical, situational-logical, mathematical, graphic methods, as well as content analysis, STEP analysis and ranking were used.Results. Providing medical and drug care to CML patients today is a vital and pressing problem in Russia and around the world. The effectiveness of pharmacotherapy directly depends on certain environmental factors, and each of them influences the functioning of a medical organization (MO) to varying degrees. Analysis of social factors made it possible to trace the dynamics and make a forecast regarding the capabilities of patients and MOs as well as the demand for drug therapy. Economic factors are based on the level of monetary income of the population and the expenditures of the RF budget on healthcare. The role of Russian export and import volumes is shown, first and foremost, the influence of these indicators on domestic prices, demand and on the macro-economic balance in general. Сreditor indebtedness changes the MO financial position and reflects the efficiency of using the monetary resources. Analysis of technological factors allowed assessing the equipment of the MO with medical facilities and drugs. The influence of such factors as the registration of new drugs for the treatment of CML patients and the digitalization program in health care was studied. Based on the analysis of political factors, the state’s interest in the development of domestic medicine and pharmacy was determined.Conclusion. The STEP analysis of external factors influencing medical and drug care for CML patients allowed identifying the most significant ones for optimizing pharmacotherapy in this category of patients, which is relevant for medical practice and the pharmaceutical industry.
Do habitus ao self realista
Authors: Souza Barbosa Saulo Vinicius 
Published: February 2024

Este artigo examina o problema da agência a partir de um diálogo entre a teoria da prática de Pierre Bourdieu e o realismo social de Margaret Archer. Baseia-se em uma reflexão comparativa entre o conceito de bourdieusiano de habitus e a concepção realista de self de Archer. Argumenta-se que a autora conserva alguns insights básicos da reflexão bourdieusiana (primado da prática, abordagem processual e estratificada do mundo social, rejeição do binarismo macro/micro). Mas, ela rompe com o resíduo estruturalista que marca a abordagem bourdieusiana a partir de um diálogo forte como realismo crítico de Roy Bhaskar e na tradição pragmática. Assim, ela restitui não só a autonomia e a reflexividade dos sujeito, bem como seu primado temporal e eficácia causal em relação as estruturas socias e culturais.
ETIKA PROFESI DA’I MENURUT AL-QUR’AN
Authors: Sihabuddin M Amin 
Published: February 2024

Tulisan ini menggambarkan aturan prilaku bagi da’i menurut al-Qur’an dalam melaksanakan dakwah Islam. Berdasarkan hasil kajian dipahami bahwa etika da’i yang diatur dalam al-Qur’an dikelompokkan pada tiga kategori, yaitu etika bertutur kata. Da’i dalam berdakwah bil al lisan menurut norma al-Qur’an haruslah dengan bahasa yang jelas (baligh), tidak memberatkan audien, bahasa yang santun (qaulan layyinah), etika bahasa sesuai dengan forumnya, dan prinsip amar ma’ruf nahi munkar; (2) Etika perbuatan, adalah pengaturan dari norma al-Qur’an tentang perbuatan da’i yaitu untuk beramal sesuai dengan perkataan, berikap kasih sayang kepada khalayak, istiqamah, mewujudkan iman dengan amal shaleh, beramal sesuai dengan syari’at Islam, meninggalkan larangan Allah dan melaksanakan perintah, tidak bersikap keras kepada khalayak dan memaksa, dan (3) etika dalam keteladanan, yaitu sebagai profil dari manifestasi nilai baik (mahmudah) menurut norma al-Qur’an bahwa keteladanan da’i, adalah jelmaan akhlak dari nilai al-Qur’an dengan penampilannya yang sopan, hubungan akrab dengan umat, menyebarkan wujud kasih sayang sebagai da’i dengan mad’u, dan berserah diri secara total terhadap nilai kebenaran al-Qur’an.
Model Layanan Bimbingan Konseling Berbasis Web dalam Mengatasi Keterbatasan Fungsi dan Peranan Penasehat Akademik Di Fakultas Dakwah dan Komunikasi UIN Raden Fatah Palembang
Authors: Noviza Neni 
Published: February 2024

Tujuan Dari penelitian ini adalah untuk mengidentifikasi kebutuhan mahasiswa akan layanan bimbingan dan konseling berbasis web di Fakultas Dakwah dan Komunikasi UIN Raden Fatah Palembang dan merumuskan model layanan bimbingan konseling berbasis website di Fakultas Dakwah dan Komunikasi UIN Raden Fatah. Metode deskriptif dengan pendekatan penelitian dan pengembangan (research and development) dengan tahap pengembangan yaitu: tahapan persiapan, tahapan pengolahan dan analisis data, tahapan merancang, validasi dan revisi model, tahap uji terbatas dan tahap revisi. Subyek penelitian adalah mahasiswa dan dosen pembimbing akademik Fakultas Dakwah dan Komunikasi.
Self Counseling Qolbun menuju Kualitas Sholat Khusyu' Aspek Esotrik Versi Pemikiran Imam AL- Ghozali
Authors: Sihabuddin Amin 
Published: February 2024

Telah dilakukan penelitian dengan judul” Self Consling Qolbu Shalat yang Khusyu’ aspek Esotorik menurut pemikiran Imam al-Ghozali” . Adapun masalah yang dibahas adalah, Bagaimana “ Self Cosling Qolbun menuju shalat yang khusyu’ menurut versi Imam Ghozali”.
Terdapat perbedaan secara esnsial tentang khusyu’ dalam shalat, karena khusyuk bersifat individual atau personal. Sufi memandang khusyuk adalah substansi shalat sebagai jiwa ( ruh) dari shalat. Bila shalat memiliki ruh maka akan memunculkan sosok orang yang beriman berakhlak dan bertakwa, serta mampu mmbentengi diri terhadap perbuatan maksiat.
Menurut Al-ghozali shalat disamping rukun zohir ( syar’i) 13 rukun, untuk menuju khusyu’ di perlukan 6 rukun bathin ( Hudurul Qolbi, al-fahmu, al-A’zhom, al- Haibah, ar-Roja’ dan al-Haya’.
Adapun hubungan khusyu’ dengan aspek bathini, yaitu berhubungan secara substansi dimana khusyu’ sebagai roh dari ibadah shalat.
Metode yang digunakan dalam penelitian ini, yaitu analisis perbandingan. Gagasan pemikiran al-Ghozali tentang shalat khusyu’ diuraikan sambil menghubungkannay dengan ulama lain.
Keyword. Self Consling qolbun, Esotorik, shalat khusyu’
Pengembangan Modul Bimbingan Karir tentang Perencanaan Karir Siswa
Authors: Karamoy Yurike Kinanthy , Afif Haris Nur , Mutakin Fakhruddin 
Published: February 2024

ABSTRACT:
This research aims to develop a media in guidance and counseling services in the form of a module on career planning to produce a module that is suitable for use for students of class X SMA Argopuro. This study uses Borg and Gall development research up to stage 5. The development procedures are: 1) needs analysis, 2) planning, 3) developing the initial product, 4) testing the initial product, and 5) revising the initial product. Based on the results of the validation test of the career guidance module on career planning, the results of the material expert assessment obtained a percentage of 85.00% in the excellent category, the results of the media expert assessment obtained a percentage of 85.00% in the excellent category, the results of the media expert assessment obtained a percentage of 92 .50% in the excellent category, and the results of the BK service expert's assessment obtained a percentage of 92.50% in the excellent category. The average score is 88.75 so it is included in the very good category and has been revised into the final product (draft 2). Thus, it can be concluded that the research product in the form of a career guidance module on career planning is declared content-worthy and can be used by BK teachers to provide an understanding of student career planning at the high school level.
Strategi Penerapan Layanan Bimbingan Dan Konseling Karir Pada Sekolah Menegah Atas Berbasis Islam Di Kurikulum Merdeka
Authors: Muliadi Marsal Yunas , Amelia Tri Putri , Masril Masril 
Published: February 2024

This research originates from the phenomenon of guidance and counseling teachers who experience problems with suitable techniques in implementing career guidance and counseling in schools. The aim of the research is to describe the strategy for implementing career guidance and counseling in senior high schools in the independent curriculum. Methods in research using qualitative. The instrument in this study was the researcher as the key, then the informants in the research were guidance and counseling teachers. Data processing techniques in this study used data reduction, data display, and drawing conclusions. Testing the validity of the data using triangulation from sources.
KEYWORDS: Strategy, guidance and counseling, career, independent curriculum
FLT3 signaling inhibition abrogates opioid tolerance and hyperalgesia while preserving analgesia
Authors: Rivat Cyril , Jouvenel Antoine , Tassou Adrien , Thouaye Maxime , Ruel Jerome , Antri Myriam , Leyris Jean-Philippe , Giraudin Aurore , Mallie Sylvie , Sar Chamroeum , Diouloufet Lucie , Sonrier Corinne , Daubeuf Francois , Bertin Juliette , Alves Stacy , Venteo Stephanie , Frossard Nelly , Carroll Patrick , Mechaly Ilana , Rognan Didier , Sokoloff Pierre , Dallel Radhouane , Delmas Patrick , Valmier Jean 
Published: February 2024

Abstract

Navigating the duality of opioids' potent analgesia and side effects, including tolerance and hyperalgesia, is a significant challenge in chronic pain management, often prompting hazardous dose escalation to maintain analgesic effects. The peripheral mu-opioid receptor (MOR) is known to mediate these contradictory effects. Here, we show that the fms-like tyrosine kinase receptor 3 (FLT3) in peripheral somatosensory neurons drives morphine tolerance and hyperalgesia. We found that chronic morphine treatment increases FLT3 and MOR co-expression, and that inhibiting FLT3 represses MOR-induced hyperactivation of the cyclic adenosine monophosphate (cAMP) signaling pathway, mitigating maladaptive excitatory processes engaged after chronic morphine treatment. Furthermore, in postsurgical or inflammatory models of chronic pain, co-administering morphine with a FLT3-specific inhibitor not only prevents or suppresses tolerance and hyperalgesia but also potentiates the analgesic efficacy of morphine. Our findings suggest that pairing morphine with FLT3 inhibitors could become a promising avenue for chronic pain management to safely harness the power of opioids, without the risk of dose escalation. By enhancing morphine analgesic potency through FLT3 inhibition, this approach could minimize opioid dosage, thereby curtailing the risk of addiction and other opioid-related side effects.
Larvae of grassland caterpillar endemic to Qinghai–Tibet Plateau (Lepidoptera: Lymantriinae: Gynaephora): identification, distribution, and ultramorphology
Authors: Yuan Chen , Shao Hainan , Fu Jinping , Liu Siyu , Liu Yunxiang 
Published: February 2024

Abstract
The grassland caterpillar is a significant pest of alpine meadows in the Qinghai-Tibet Plateau. Its larvae primarily feed on forage grasses, resulting in financial losses. However, little research has been done on the morphological features of larvae of this species thus far. The distribution and habitat of Gynaephora menyuanensis were extensively investigated in this instance through field study. Using an optical and scanning electron microscope(SEM), the external morphology and ultramorphology of the last instar larvaeof G. menyuanensiswere investigated. The findings indicate that this species is primarily found in the northeast of Qinghai Province in alpine meadows at an altitude of 3,000–3,500 m. For the first time, SEM is used to report more comprehensive morphological structuresof G. menyuanensis, including larval head capsule, mouthparts, antenna, sensilla, thoracic legs, prolegs, and setae. The larvae have two distinct color funnel warts (yellow and red) on abdominal segments VI and VII, which sets them apart from other lepidopterous larvae. Additionally, the chaetotaxy of first instar larvae of G. menyuanensis were studied and described in detail, identifying seven clusters(PD, D, SD, L, SV, V, CV) on the larval trunk. This study offers a theoretical basis for phylogenetic analysis, the adaption evolution of G. menyuanensis, and a systematic discussion of the application of morphological features of larvae to classification.
Research on key technology of cooled infrared bionic compound eye camera based on small lens array
Authors: wang xiaoyu , Linhan Li , Yinghao Chi , Liu Jie , Juan Yuan , Sili Gao , Xiupeng Yuan , Yang Yu 
Published: February 2024

Abstract
With the development of imaging technology, traditional two-dimensional imaging technology has difficulty meeting the observation needs of a large field of view, and has a high sensitivity to the movement of small targets. Inspired by the characteristics of the insect compound eye structure, this paper proposes an infrared bionic compound eye camera based on a small lens array. The camera consists of 61 small lens arrays mounted on a curved spherical shell and a relay optical system, and the imaging device is a high-performance cooled mid-wave infrared detector. This is an innovative design of an infrared biomimetic compound eye camera system with a wide field of view and all-day detection capability. To meet the requirement of 100% cold-membrane matching between the infrared optical system and the cooled detector, the relay optical system optimizes the large-field aberration by introducing a higher-order aspherical surface and changing the geometric surface of the lenses, and the whole system realizes an observation field angle of 108 °× 108 °. The experiments showed that the image quality of each ommatidium was good in the imaging range of the compound eye camera, and the imaging signal-to-noise ratio improved in various scenes.
A Well-being Promotion Program Increases Self-Compassion, Resilience and Active Coping among Providers Who Work with Children and Families
Authors: Lengua Liliana J. , Calhoun Rebecca , Balinbin Ignatius , Long Robyn , Spink Katie Malloy , Angeles Marie 
Published: February 2024

Abstract

This study examined the effects of the REsilient Attitudes and Living for Professionals (REAL Pro) prevention intervention on the well-being of professionals who work with children and families. The program combines mindfulness and self-compassion practices with cognitive-behavioral tools that aim to promote improved stress management, emotion regulation and well-being, and was evaluated with early childhood (n = 87) and K-12 educators (n = 40), staff serving youth in out-of-school or after-school settings (n = 31), and medical providers (n = 35). Participants completed pre- and post-test assessments, reporting on measures of stress management (perceived stress, self-compassion), emotion regulation (dysregulation, active coping, denial), and well-being (flourishing, resilience, burnout, secondary trauma symptoms). Dependent sample t-tests were conducted, showing significant improvement from pre- to post-test in self-compassion, emotion regulation, active coping, and a trend toward increased resilience. Three-month follow-up in a small subset of the sample (n = 11) suggested potential delayed reduction in burnout and secondary trauma symptoms. The preventive intervention shows promise for providing professionals with tools for stress management and emotion regulation and reducing burnout in providers working with children and families who tend to experience substantial work-related stress.