bluuebunny/crossref_metadata_2025_split huggingface dataset:
Preoperative contrast-enhanced CT imaging and clinicopathological characteristics analysis of mismatch repair-deficient colorectal cancer
Authors: Chen Shuai , Du Wenzhe , Cao Yuhai , Kong Jixia , Wang Xin , Wang Yisen , Lu Yang , Li Xiang 
Published: October 2023

Abstract
Background
Colorectal cancer (CRC) can develop through various pathogenetic pathways, and one of the primary pathways is high microsatellite instability (MSI-H)/deficient mismatch repair (dMMR). This study investigated the correlation between preoperative contrast-enhanced CT (CECT) and clinicopathologic characteristics of colorectal cancer (CRC) according to different mismatch repair (MMR) statuses.

Methods
From April 2021 to July 2022, a total of 281 CRC patients with preoperative CECT and available MMR status were enrolled from a single centre for this retrospective study. Preoperative CECT features and clinicopathologic characteristics were analysed. Univariate and multivariate logistic regression analyses were used for statistical analysis. A nomogram was established based on the multivariate logistic regression results. Preoperative and postoperative dynamic nomogram prediction models were established. The C-index, a calibration plot, and clinical applicability of the two models were evaluated, and internal validation was performed using three methods.

Results
In total, 249 patients were enrolled in the proficient mismatch repair (pMMR) group and 32 patients in the deficient mismatch repair (dMMR) group. In multivariate analysis, tumour location (right-hemi colon vs. left-hemi colon, odds ratio (OR) = 2.90, p = .036), the hypoattenuation-within-tumour ratio (HR) (HR > 2/3 vs. HR < 1/3, OR = 36.7, p < .001; HR 1/3–2/3 vs. HR < 1/3, OR = 6.05, p = .031), the number of lymph nodes with long diameter ≥ 8 mm on CECT (OR = 1.32, p = .01), CEA status (CEA positive vs. CEA negative, OR = 0.07, p = .002) and lymph node metastasis (OR = 0.45, p = .008) were independent risk factors for dMMR. Pre- and postoperative C-statistic were 0.861 and 0.908, respectively.

Conclusion
The combination of pre-operative CECT and clinicopathological characteristics of CRC correlates with MMR status, providing possible non-invasive MMR prediction. Particularly for dMMR CRC, tumour-draining lymph node status should be prudently evaluated by CECT.
Standardized protocol of blood pressure measurement and quality control program for the Korea National Health and Nutrition Examination Survey
Authors: Kim Hack-Lyoung , Park Sang Min , Cho In Jeong , Kim Yu-Mi , Kim Dae-Hee , Kim Sung Hye , Kim Kwang-Il , Sung Ki-Chul , Ihm Sang-Hyun , Shin Jinho , Kim Yoonjung , Oh Kyungwon , Lee Eun Mi ,   Quality control team of blood pressure measurements for the Korea National Health, Nutrition Examination Survey (KNHANES)
Published: October 2023

AbstractAccurate blood pressure (BP) measurement is crucial for hypertension detection and management. The Korea National Health and Nutrition Examination Survey (KNHANES) assesses the health of Koreans using representative cross-sectional data. BP measurements were historically done with mercury sphygmomanometers for participants aged ≥10 years. However, KNHANES transitioned to Greenlight 300TM (mercury-free auscultatory device) in 2020 for participants aged ≥6 years and used dual devices (Microlife WatchBP Office AFIB and Greenlight) in 2021-2022. To ensure consistency, KNHANES will adopt Microlife as the unified BP device with Greenlight for device validation from 2023. Under the new protocol, participants aged ≥6 years will have their BP measured three times at 30-second intervals after a 5-minute rest under ambient temperature (20-25℃) and noise ≤65 dB. The average of the 2nd and 3rd readings will be used as the representative BP value. The quality control (QC) program involves four trained examiners passing the “quality control and assurance of BP measurement program” three times annually, and undergoing “video monitoring of weekly calibration process” once a year. Additionally, the QC team will conduct “on-site evaluations of BP measurement” at mobile examination centers three times a year. A Five-Step QC process for BP devices was also developed. This document outlines the standardized BP measurement protocol and rigorous QC program in KNHANES, aiming to ensure accurate and reliable BP data for epidemiological research and public health policymaking in South Korea.
Graphical Abstract
The INSCHOOL project: showcasing participatory qualitative methods derived from patient and public involvement and engagement (PPIE) work with young people with long-term health conditions
Authors: Spencer Bethan , Hugh-Jones Siobhan , Cottrell David , Pini Simon 
Published: October 2023

Abstract
Background
Evidence suggests resources and services benefit from being developed in collaboration with the young people they aim to support. Despite this, patient and public involvement and engagement (PPIE) with young people is often tokenistic, limited in engagement and not developmentally tailored to young people. Our paper aims to build knowledge and practice for meaningfully engaging with young people in research design, analysis and as research participants.

Methods
We report the participatory processes from the INSCHOOL project, examining long-term health conditions and schooling among 11–18 year olds. Young people were consulted at the inception of the project through a hospital-based youth forum. This began a partnership where young people co-designed study documents, informed the recruitment process, developed creative approaches to data collection, participated in pilot interviews, co-analysed the qualitative data and co-presented results.

Results
PPIE advisors, participants and researchers all benefitted from consistent involvement of young people throughout the project. Long-term engagement allowed advisors and researchers to build rapport and facilitated openness in sharing perspectives. PPIE advisors valued being able to shape the initial aims and language of the research questions, and contribute to every subsequent stage of the project. Advisors co-designed flexible data collection methods for the qualitative project that provided participants with choices in how they took part (interviews, focus groups, written tasks). Further choice was offered through co-designed preparation activities where participants completed one of four creative activities prior to the interview. Participants were therefore able to have control over how they participated and how they described their school experiences. Through participatory analysis meetings advisors used their first-hand experiences to inform the creation of themes and the language used to describe these themes. PPIE in every stage of the process helped researchers to keep the results grounded in young people’s experience and challenge their assumptions as adults.

Conclusions
Young people have much to offer and the INSCHOOL project has shown that researchers can meaningfully involve young people in all aspects of research. Consistent PPIE resulted in a project where the voices of young people were prioritised throughout and power imbalances were reduced, leading to meaningful participant-centred data.
Involving patients in healthcare research is well documented but can it work in lab-based research?
Authors: Connor Adele E. , Hughes Claire , Schäfer Lea , McNally Lorraine , Raw Deirdre O’ , Bahramian Katayoun , Carr Bridget , Dunne Ingrid Halligan , Lysaght Joanne , Toole Sharon A. O’ , Simpson Jeremy C. , Perry Antoinette S. 
Published: October 2023

AbstractPublic and Patient Involvement in research is becoming a requirement on most research funding applications; this includes both healthcare and lab-based research. Whilst case studies and practical guides have been developed and are well documented for PPI in healthcare research, there is very little guidance available for PPI in lab-based research. In this piece we discuss our experience of how we have successfully involved patients in our translational cancer research, which is focused on developing personalised treatment for high-grade serous ovarian cancer. We discuss the benefits it has made to both our research and to us as researchers. The patients involved write about their experience, what they enjoyed, and the benefits they felt. Although PPI is quite topical and is being widely discussed, there is hesitancy among researchers, especially those in lab-based research about getting started because of a lack of practical guidance about how to implement it. Here, we have shared our experience, hopefully providing a practical example of how PPI can be incorporated into a lab-based research project.
State of the art procedures towards reactive [18F]fluoride in PET tracer synthesis
Authors: Haveman Lizeth Y. F. , Vugts Danielle J. , Windhorst Albert D. 
Published: October 2023

Abstract
Background
Positron emission tomography (PET) is a powerful, non-invasive preclinical and clinical nuclear imaging technique used in disease diagnosis and therapy assessment. Fluorine-18 is the predominant radionuclide used for PET tracer synthesis. An impressive variety of new ‘late-stage’ radiolabeling methodologies for the preparation of 18F-labeled tracers has appeared in order to improve the efficiency of the labeling reaction.

Main body
Despite these developments, one outstanding challenge into the early key steps of the process remains: the preparation of reactive [18F]fluoride from oxygen-18 enriched water ([18O]H2O). In the last decade, significant changes into the trapping, elution and drying stages have been introduced. This review provides an overview of the strategies and recent developments in the production of reactive [18F]fluoride and its use for radiolabeling.

Conclusion
Improved, modified or even completely new fluorine-18 work-up procedures have been developed in the last decade with widespread use in base-sensitive nucleophilic 18F-fluorination reactions. The many promising developments may lead to a few standardized drying methodologies for the routine production of a broad scale of PET tracers.
Effects of child abuse and neglect on executive functions among children diagnosed with learning disabilities or attention deficit and hyperactivity disorder
Authors: Maged Hamza Aya , Ghobashy Soha Abdellatif , Abouelwafa Heba Essam 
Published: October 2023

Abstract
Background
Studying cognitive deficits due to abuse and neglect in vulnerable children with neurodevelopmental disorders can fuel the battle to save them. We aimed to assess effects of child abuse and neglect on executive functions (EF) among children diagnosed with attention deficit and hyperactivity disorder (ADHD) and specific learning disorders (SLD). Three hundred forty drug-naive children were divided into four groups according to their diagnosis. They have all been through history taking, clinical interview, assessment of exposure to abuse or neglect, Barkley Deficit in Executive Functioning Scale-Children and Adolescents (BDEFS-CA), and Conners and intelligence quotient (IQ) test.

Results
Children with ADHD or SLD were significantly exposed to abuse and neglect showing significant executive dysfunctions. The mostly affected domains with abuse among ADHD were emotion regulation with effect size (ES): 0.576, self-restraint ES: 0.38 and self-motivation ES: 0.256, abuse was significantly associated with lower social class 63.6% ES: 0.377 while neglect was significantly associated with parents’ marital status of being divorced 92% ES: 0.621. Abuse and neglect were significantly associated with emotion regulation executive dysfunction with OR 23.5 and 22.8 respectively.

Conclusion
Executive dysfunctions are significantly related to exposure to abuse and neglect. The most affected domains were emotion regulation and self-restraint executive functions. Also, we concluded that prevalence of abuse and neglect to be significantly higher in lower social class than average and higher classes and in divorced parents than married ones. Health education and early intervention programs should be directed more specifically to the more vulnerable children diagnosed with neurodevelopmental disorders and of lower social class or of divorced parents.
The impact of macroeconomic and institutional environment on NPL of developing and developed countries
Authors: Goyal Shikha , Singhal Nikita , Mishra Nandita , Verma Subhash Kumar 
Published: October 2023

AbstractThe study investigates what causes non-performing loans (NPLs) in developed and developing countries. To identify the relationship between bank-specific, macroeconomic determinants, and institutional environment non-performing loans on country-level panel data of Developing nations for the period extending from 2010 to 2020, the author used panel system GMM methodology. The long-held hypothesis that NPLs contribute to economic growth is tested using the Panel Granger causality test. Further panel cointegration tests were run to see whether the two variables have a long-term relationship. According to the study, loan defaults frequently happen at a lower rate during a rapid economic expansion, resulting in lower levels of non-performing loans. If there is a robust regulatory framework for systemic risk, a larger banking sector should be more stable than a smaller one. The current study also demonstrates the institutional environment’s importance in improving banks’ credit quality. In developing and developed countries, NPLs are significantly reduced when the institutional environment is improved.
Assessment of computational approaches in the prediction of spectrogram and chromatogram behaviours of analytes in pharmaceutical analysis: assessment review
Authors: Malarvannan M. , Kumar K. Vinod , Reddy Y. Padmanabha , Nikhil Pallaprolu , Aishwarya Dande , Ravichandiran V. , Ramalingam P. 
Published: October 2023

Abstract
Background
Today, artificial intelligence-based computational approach is facilitating multitasking and interdisciplinary analytical research. For example, the data gathered during an analytical research project such as spectral and chromatographic data can be used in predictive experimental research. The spectral and chromatographic information plays crucial role in pharmaceutical research, especially use of instrumental analytical approaches and it consume time, man power, and money. Hence, predictive analysis would be beneficial especially in resource-limited settings.

Main body
Computational approaches verify data at an early phase of study in research process. Several in silico techniques for predicting analyte’s spectral and chromatographic characteristics have recently been developed. Understanding of these tools may help researchers to accelerate their research with boosted confidence and prevent researchers from being misled by incorrect analytical data. In this communication, the properties of chemical compounds and its relation to chromatographic retention will be discussed, as well as the prediction technique for UV/IR/Raman/NMR spectrograms. This review looked at the reference data of chemical compounds to compare the predictive ability in silico tools along with the percentage error, limitations, and advantages.

Conclusion
The computational prediction of analytical characteristics offers a wide range of applications in academic research, bioanalytical method development, computational chemistry, analytical method development, data analysis approaches, material characterization, and validation process.
Toward an integrated approach for mental health and psychosocial support and peacebuilding in North-East Nigeria: programme description and preliminary outcomes from ‘Counselling on Wheels’
Authors: Paphitis Sharli , Akilu Fatima , Chilambo Natasha , Iruayenama Abiye , Samaroo Xena , Mustapha Asma'u , Goldsmith Kimberley , Ismail Olawale , Slovak Petr , Ikpe Eka , Smith Patrick , Patel Preeti , Sullivan Richard , Abas Melanie , Olonisakin Funmi 
Published: October 2023

Background
Despite theoretical support for including mental health and psychosocial support (MHPSS) with peacebuilding, few programmes in conflict-affected regions fully integrate these approaches.

Aims
To describe and assess preliminary outcomes of the Counselling on Wheels programme delivered by the NEEM Foundation in the Borno State of North-East Nigeria.

Method
We first describe the components of the Counselling on Wheels programme, including education and advocacy for peace and social cohesion through community peacebuilding partnerships and activities, and an MHPSS intervention open to all adults, delivered in groups of eight to ten people. We then conducted secondary analysis of data from 1550 adults who took part in the MHPSS intervention, who provided data at baseline and 1–2 weeks after the final group session. Vulnerability to violent extremism was assessed with a locally developed 80-item scale. Symptoms of common mental disorders were assessed with the Depression, Anxiety and Stress Scale (DASS-21) and Post-Traumatic Stress Disorder Scale (PTSD-8). Data were analysed through a mixed-effect linear regression model, accounting for clustering by community and adjusted for age and gender.

Results
After taking part in group MHPSS, scores fell for depression (−5.8, 95% CI −6.7 to −5.0), stress (−5.5, 95% CI −6.3 to −4.6), post-traumatic stress disorder (−2.9, 95% CI −3.4 to −2.4) and vulnerability to violent extremism (−44.6, 95% CI −50.6 to −38.6).

Conclusions
The Counselling on Wheels programme shows promise as a model for integrating MHPSS with community peacebuilding activities in this conflict-affected region of Africa.
Patient and therapist experiences of exposure therapy for anxiety-related disorders in pregnancy: qualitative analysis of a feasibility trial of intensive versus weekly CBT
Authors: Challacombe Fiona L. , Sabin Katherine , Jacobson Samantha , Tinch-Taylor Rose , Potts Laura , Carter Ben , Lawrence Vanessa 
Published: October 2023

Background
Approximately 15% of pregnant women experience anxiety disorders. Effective treatments exist but their acceptability during pregnancy, particularly exposure therapy, is not known.

Aims
To understand patient and therapist experiences of time-intensive and weekly exposure-based therapy for anxiety disorders delivered during pregnancy. Trial registration: ISRCTN81203286.

Method
In-depth interviews were conducted with patients and therapists who had taken part in a feasibility trial of predominantly online time-intensive versus weekly cognitive–behavioural therapy in pregnancy in a primary care setting in the UK. Data were analysed using reflexive thematic analysis.

Results
In total, 45 women participating in the trial and 6 therapists who had delivered the treatments were interviewed. Five themes were developed from the data that showed convergence from therapist and patient perspectives: ‘Acquiring tools to navigate the perinatal period’; ‘Motivated yet constrained by pregnancy’; ‘Having the confidence to face fears and tolerate uncertainty’; ‘Momentum with the need for flexibility’; ‘Being removed from the face-to-face world’.

Conclusions
Exposure therapy is acceptable and helpful in pregnancy and can lead to lasting gains. Exposure is a key element of treatment and needs to be confidently conducted by therapists with perinatal knowledge and expertise. Treatments need to consider the unfolding context of pregnancy. The momentum of intensive therapy can lead to rapid improvements, but is demanding for both patients and therapists, especially fitting round other commitments. Online treatments can work well and are a good fit for perinatal women, but this needs to be balanced with the need for social connection, suggesting a hybrid model is the ideal.
Long-Term Results After Surgery for Degenerative Cervical Myelopathy
Authors: Johansen Tonje O. , Holmberg Siril T. , Danielsen Elisabet , Rao Vidar , Salvesen Øyvind O. , Andresen Hege , Carmen Vleggeert-Lankamp L. A. , Solberg Tore K. , Gulati Sasha , Nygaard Øystein P. 
Published: October 2023

BACKGROUND AND OBJECTIVES:
Degenerative cervical myelopathy (DCM) is a frequent cause of spinal cord dysfunction, and surgical treatment is considered safe and effective. Long-term results after surgery are limited. This study investigated long-term clinical outcomes through data from the Norwegian registry for spine surgery.

METHODS:
Patients operated at the university hospitals serving Central and Northern Norway were approached for long-term follow-up after 3 to 8 years. The primary outcome was change in the Neck Disability Index, and the secondary outcomes were changes in the European Myelopathy Scale score, quality of life (EuroQoL EQ-5D); numeric rating scales (NRS) for headache, neck pain, and arm pain; and perceived benefit of surgery assessed by the Global Perceived Effect scale from 1 year to long-term follow-up.

RESULTS:
We included 144 patients operated between January 2013 and June 2018. In total, 123 participants (85.4%) provided patient-reported outcome measures (PROMs) at long-term follow-up. There was no significant change in PROMs from 1 year to long-term follow-up, including Neck Disability Index (mean 1.0, 95% CI −2.1-4.1, P = .53), European Myelopathy Scale score (mean −0.3, 95% CI −0.7-0.1, P = .09), EQ-5D index score (mean −0.02, 95% CI −0.09-0.05, P = .51), NRS neck pain (mean 0.3 95% CI −0.2-0.9, P = .22), NRS arm pain (mean −0.1, 95% CI −0.8-0.5, P = .70), and NRS headache (mean 0.4, 95% CI −0.1-0.9, P = .11). According to Global Perceived Effect assessments, 106/121 patients (87.6%) reported to be stable or improved (“complete recovery,” “much better,” “slightly better,” or “unchanged”) at long-term follow-up compared with 88.1% at 1 year. Dichotomizing the outcome data based on severity of DCM did not demonstrate significant changes either.

CONCLUSION:
Long-term follow-up of patients undergoing surgery for DCM demonstrates persistence of statistically significant and clinically meaningful improvement across a wide range of PROMs.
Protocol for correlation of histological risk assessment/scoring system with a depth of invasion in oral squamous cell carcinoma
Authors: Sonone Archana , Hande Alka , Pakhale Aayushi , Gawande Madhuri , Patil Swati 
Published: October 2023

Introduction: The commonest type of cancer in the head and neck region is oral squamous cell carcinoma (OSCC) due to its high rates of occurrence and mortality. The early diagnosis of oral cancer gives better prognosis. Brandwein-Gensler criteria predict the early stage of OSCC cases with a high risk of locoregional recurrence. Objectives: To correlate Brandwein-Gensler criteria and depth of invasion of OSCC with three-year survival. Methodology: In the study, hematoxylin-eosin (HE)-stained section slides will be used to evaluate Brandwein and Gensler criteria and depth of invasion in resected tissue specimens of OSCC cases. Expected results: The present study will find the correlation between Brandwein-Gensler criteria and depth of invasion in OSCC in order to evaluate the locoregional recurrence in OSCC cases. In high-risk OSCC cases, there may be increased depth of invasion in resected tissues. Conclusions: We hypothesized that the correlation between Brandwein-Gensler criteria and depth of invasion can be used as an independent predictor for locoregional recurrence in OSCC.