bluuebunny/crossref_metadata_2025_split huggingface dataset:
Myeloid spatial and transcriptional molecular signature of ischemia-reperfusion injury in human liver transplantation
Authors: Sosa Rebecca A. , Ahn Richard , Li Fang , Terry Allyson Q. , Qian Zach , Bhat Adil , Sen Subha , Naini Bita V. , Ito Takahiro , Kaldas Fady M. , Hoffmann Alexander , Busuttil Ronald W. , Kupiec-Weglinski Jerzy W. , Gjertson David W. , Reed Elaine F. 
Published: January 2024

Background:
Ischemia-reperfusion injury (IRI) is a significant clinical concern in liver transplantation, with a key influence on short-term and long-term allograft and patient survival. Myeloid cells trigger and sustain tissue inflammation and damage associated with IRI, but the mechanisms regulating these activities are unknown. To address this, we investigated the molecular characteristics of intragraft myeloid cells present in biopsy-proven IRI− and IRI+ liver transplants.

Methods:
RNA-sequencing was performed on 80 pre-reperfusion and post-reperfusion biopsies from 40 human recipients of liver transplantation (23 IRI+, 17 IRI−). We used transcriptional profiling and computational approaches to identify specific gene coexpression network modules correlated with functional subsets of MPO+, lysozyme+, and CD68+ myeloid cells quantified by immunohistochemistry on sequential sections from the same patient biopsies.

Results:
A global molecular map showed gene signatures related to myeloid activation in all patients regardless of IRI status; however, myeloid cell subsets differed dramatically in their spatial morphology and associated gene signatures. IRI− recipients were found to have a natural corticosteroid production and response profile from pre-reperfusion to post-reperfusion, particularly among monocytes/macrophages. The pre-reperfusion signature of IRI+ recipients included acute inflammatory responses in neutrophils and increased translation of adaptive immune-related genes in monocytes/macrophages coupled with decreased glucocorticoid responses. Subsequent lymphocyte activation at post-reperfusion identified transcriptional programs associated with the transition to adaptive immunity found only among IRI+ recipients.

Conclusions:
Myeloid subset-specific genes and related signaling pathways provide targets for the development of therapeutic strategies aimed at limiting IRI in the clinical setting of liver transplantation.
Comparison of 2 Different Treatments for Conjunctivochalasis: Plasma-Based Conjunctivoplasty Versus Argon Laser Photocoagulation
Authors: Ucar Fikret , Unluzeybek Murat 
Published: January 2024

Purpose:
The aim of this study was to compare the clinical outcomes of plasma-based conjunctivoplasty and argon laser photocoagulation techniques used in the treatment of conjunctivochalasis.

Methods:
The study included 119 eyes from 67 patients who underwent plasma-based conjunctivoplasty or argon laser photocoagulation for conjunctivochalasis in our clinic between February 2021 and March 2022. Group 1 included 62 eyes from 35 patients who had plasma-based conjunctivoplasty. Group 2 included 57 eyes from 32 patients who had argon laser photocoagulation. Main outcomes were patient symptoms, the degree of conjunctivochalasis, fluorescein staining score, tear breakup time, the amount of conjunctival shrinkage, and complications.

Results:
Before surgery, Group 1 had grade 1 conjunctivochalasis in 8 eyes (12.9%), grade 2 in 20 eyes (32.2%), and grade 3 in 34 eyes (54.8%). In Group 2, 9 eyes (15.7%) had grade 1, 21 eyes (36.8%) had grade 2, and 27 eyes (47.3%) had grade 3 conjunctivochalasis (P = 0.43). At the sixth postoperative month, only 2 eyes (3.2%) in Group 1 had grade 1 conjunctivochalasis, whereas the other cases (96.7%) had no conjunctivochalasis. However, Group 2 had grade 1 conjunctivochalasis in 16 eyes (28.0%), grade 2 in 21 eyes (36.8%), and grade 3 in 2 eyes (3.5%). Conjunctival shrinkage in Group 1 (5.1 ± 1.2 mm) was significantly higher than in Group 2 (3.3 ± 0.9 mm; P < 0.001). Postoperative tear breakup time in Group 1 (10.2 ± 2.1 seconds) was significantly longer than in Group 2 (8.8 ± 2.0 seconds; P < 0.001).

Conclusions:
Plasma-based conjunctivoplasty demonstrated greater clinical improvement and efficacy than argon laser photocoagulation for the treatment of conjunctivochalasis.
Implementation of optical coherence tomography in retinopathy of prematurity screening
Authors: Hanif Adam M. , Jian Yifan , Young Benjamin K. , Campbell John Peter 
Published: January 2024

Purpose of review
In this review, we explore the investigational applications of optical coherence tomography (OCT) in retinopathy of prematurity (ROP), the insights they have delivered thus far, and key milestones for its integration into the standard of care.

Recent findings
While OCT has been widely integrated into clinical management of common retinal diseases, its use in pediatric contexts has been undermined by limitations in ergonomics, image acquisition time, and field of view. Recently, investigational handheld OCT devices have been reported with advancements including ultra-widefield view, noncontact use, and high-speed image capture permitting real-time en face visualization. These developments are compelling for OCT as a more objective alternative with reduced neonatal stress compared to indirect ophthalmoscopy and/or fundus photography as a means of classifying and monitoring ROP.

Summary
OCT may become a viable modality in management of ROP. Ongoing innovation surrounding handheld devices should aim to optimize patient comfort and image resolution in the retinal periphery. Future clinical investigations may seek to objectively characterize features of peripheral stage and explore novel biomarkers of disease activity.
The Effects of Long-Term Walking Exercise on Structural Progression, Symptoms, and Extensor Muscle Strength in Patients with Mild or at High Risk of Knee Osteoarthritis: Data from the Osteoarthritis Initiative
Authors: Zhang Hui , Wang Junqing , Shuai Tao , Li Kang , Nie Yong 
Published: January 2024

Abstract

Objective
To assess the relationship between walking exercise and medial joint space narrowing (JSN) progression, symptoms, and knee extensor muscle strength (EMS) in early knee osteoarthritis (OA) patients.

Methods
This nested cohort study within the Osteoarthritis Initiative included participants aged 50 and above with knee OA (Kellgren-Lawrence grades 0-2). Walking exercisers were identified using a modified Historical Physical Activity Survey Instrument. Differences in medial JSN, Knee Injury and Osteoarthritis Outcome Score (KOOS), and knee EMS were evaluated through the three-way ANOVA.

Results
Among 896 participants, 83.4% reported walking exercise. Female walkers showed significant improvements in symptoms (KOOS-Pain: P < 0.001; KOOS-Symptom: P < 0.001; KOOS-Quality of Life (QOL): P < 0.001; KOOS-Function, Sports, and Recreational Activities (FSR): P = 0.007). Similar results were observed in male walkers (KOOS-Pain: P < 0.001; KOOS-Symptom: P < 0.001; KOOS- QOL: P = 0.001; KOOS- FSR: P = 0.009). Walkers showed significantly increased knee EMS at 24 months (Female: P < 0.001; Male: P = 0.003). Female non-walkers had significantly decreased knee EMS at 24 months (P < 0.001). Walkers showed significant improvement in medial JSN (OR = 1.1, 95% CI: 1.0 to 1.2) and KL grade (OR = 1.0, 95% CI: 1.0 to 1.1) compared to non-walkers.

Conclusion
Walking exercise prevents structural progression and improves symptoms. Meanwhile, the increased knee EMS in all walkers further supports the validity of recommending walking exercises for early-stage knee OA patients.
Are your patients safe to mobilize alone in their room? The Johns Hopkins Hospital In-Room Independence Scale (JH-IRIS)
Authors: Reoli Rachel , Wilkins Erik , Klag Julia , Hoyer Erik , Lavezza Annette 
Published: January 2024

AbstractObjectiveGiven the stigma of falls while hospitalized, inpatient rehabilitation facilities (IRF) often restrict the independent room mobility of their patients. We assessed the psychometric properties of a new tool, the Johns Hopkins In-Room Independence Scale (JH-IRIS), to evaluate its effectiveness at identifying independence for in-room mobility.DesignConstruct validity was assessed by comparing the JH-IRIS to its “gold standard” counterparts, The Johns Hopkins Falls Risk Assessment Tool (JHFRAT), the Activity Measure for Post-Acute Care (AM-PAC) Mobility and Activity, and the Centers for Medicare Quality Indicators (QI). Reliability was assessed via Cronbach’s Alpha.Results197 episodes were included. Construct validity: JH-IRIS had significantly negative low correlation to the JHFRAT (Spearman’s Rho –0.281), and a significant moderate correlation to the AM-PAC Activity and AM-PAC Mobility (Spearman’s Rho, 0.678 and 0.530, respectively). The JH-IRIS was moderately positively correlated to the QIs for mobility and activity (Spearman’s Rho 0.577 and 0.643, respectively). All two tailed, alpha level 0.01. JH-IRIS' reliability was strong (Cronbach’s Alpha 0.822, 15 items). Sensitivity and specificity were both 100%.ConclusionGiven the moderate validity, strong reliability, and high sensitivity/specificity, our study suggests the JH-IRIS can be used to identify patients who have the capacity to mobilize independently in their room.
Characteristics and Methodological Quality of the Top 50 Most Influential Articles on Stroke Rehabilitation: A Bibliometric Analysis
Authors: Ogihara Hirofumi , Yamamoto Norio , Kurasawa Yasuyuki , Kamo Tomohiko , Hagiyama Akikazu , Hayashi Shota , Momosaki Ryo 
Published: January 2024

AbstractThis study aimed to conduct a comprehensive review of the top 50 most influential articles on stroke rehabilitation to investigate characteristics such as the number of citations, year of publication, study design, and research topic, as well as to assess the evidence level and methodological quality. Moreover, we performed a supplementary assessment of the top ten articles published within the past 5 years in the same domain, aiming to discern potential shifts in trends and methodological quality. Web of Science was used to search for articles on stroke rehabilitation. The data extracted from the articles included title, journal impact factor, year of publication, total number of citations, article topic, study design and others. The level of evidence and methodological quality were assessed by two reviewers. Non-invasive brain stimulation and robotic rehabilitation were frequently discussed in the top 50 articles. We found that there was no difference in methodology quality between the top 50 articles in all years and the top ten articles in the past 5 years. Furthermore, the number of citations and citation density were not associated with the methodological quality. The findings suggest that the number of citations alone may not be a reliable indicator of research quality.
Association of age and sex at onset with Glenohumeral Osteoarthritis: A systematic review and meta-analysis
Authors: Prakash Ravi , Gardner James E. , Petric Ursa B. , Pathak Rashmi , Atem Folefac , Jain Nitin B. 
Published: January 2024

AbstractObjectiveThe aim of the present systematic review is to synthesize existing evidence (qualitative and quantitative) regarding age- and sex-specific differences with glenohumeral osteoarthritis (GH OA).DesignThe electronic databases PubMed, Medline and Web of Science were searched up to March 15, 2023. Articles reporting on the association of risk factors (age and sex) with GH OA were considered. We used Newcastle-Ottawa scale to assess study quality. Meta-analysis was conducted to quantitatively summarize the association of age and sex with GH OA.ResultsA total of 24 articles were retrieved for full-text review. Out of twenty-four articles, 8 articles reporting age-specific and 5 articles reporting sex-specific associations with GH OA were included. The odds ratio (OR) for the age [OR-3.18; 95% confidence interval (CI)-1.10-15.92] and female sex [OR-1.78; 95%CI-0.95-3.42] were increased and observed statistically significant.ConclusionsThe present systematic review and meta-analysis suggests the role of increasing age as one of the significant contributors to GH OA. However, association of female sex with GH OA is least convincing. Future studies are required to understand the molecular mechanisms behind the contributory role of increasing age and female sex in the establishment of GH OA.
Role of Outpatient Physical Medicine and Rehabilitation in a Multidisciplinary Prehabilitation Program for Older Adults Before Allogeneic Hematopoietic Stem Cell Transplant
Authors: Cheng Jessica T. , Obaisi Obada , Yadav Rajesh , Gupta Ekta , Fu Jack B. , Bruera Eduardo , Collaco Alisha , Szewczyk Nicholas , Popat Uday R. , Ngo-Huang An 
Published: January 2024

Introduction
Physical rehabilitation is increasingly incorporated throughout the allogeneic hematopoietic stem cell transplant journey for older adults.

Objective
This study aimed to describe physical medicine and rehabilitation–related diagnoses, exercise barriers, and management recommendations for older adults before allogeneic hematopoietic stem cell transplant.

Design
Fifty physical medicine and rehabilitation consults as part of the Enhanced Recovery-Stem Cell Transplant multidisciplinary prehabilitation program at a comprehensive cancer center were retrospectively reviewed.

Results
Many physical medicine and rehabilitation–related diagnoses (173), exercise barriers (55), and management recommendations (112) were found. Common diagnoses were musculoskeletal dysfunction (more commonly back, shoulder, then knee) (n = 39, 23%) and fatigue (n = 36, 21%). Common exercise barriers were also musculoskeletal dysfunction (more commonly back, knee, then shoulder) (total n = 20, 36%) and fatigue (n = 20, 36%). Most patients (n = 32, 64%) had one or more exercise barriers. Common physical medicine and rehabilitation management recommendations were personalized exercise counseling (n = 37, 33%), personalized nutrition management (n = 19, 17%), body composition recommendations (n = 17, 15%), medications (n = 15, 13%), and orthotics and durable medical equipment (n = 8, 7%).

Conclusions
Routine physical medicine and rehabilitation referral of older allogeneic hematopoietic stem cell transplant patients for prehabilitation resulted in the identification of many rehabilitative needs and substantial additional management recommendations. Increased early, collaborative prehabilitation efforts between physical medicine and rehabilitation and allogeneic hematopoietic stem cell transplant teams to optimize care for these patients is recommended.
Age-Related Trajectory and Age at Peak Competitive Performance in Wheelchair Rugby Players at the Paralympic Games
Authors: Gomes Costa Rodrigo Rodrigues , Ribeiro Neto Frederico , Ramos Beatriz Lucena , Tanhoffer Ricardo , O’Shea Bob , Winckler Ciro 
Published: January 2024

Objective
The first objective is to examine the age-related trajectory of competitive performance and the age at peak competitive performance in wheelchair rugby players at the Paralympic Games. Another objective is to verify age correlations with performance over the years for each class.

Design
This is a retrospective cohort study.

Results
Data were collected from the official results books of the Paralympic games. The mean age (SD) of the 267 players and 448 analyzed data from all Paralympic games (from Sidney 2004 to Tokyo 2020) across all classes was 32.8 (6.4) yrs, and the age at peak competitive performance was 30.6 (7.4) yrs. Each class had no statistical difference in age at peak competitive performance. In addition, there was no significant correlation between age and performance within classes or across all Paralympic games.

Conclusions
The findings indicate that wheelchair rugby players’ age at peak competitive performance is 30.6 yrs, which remains consistent across all classes. There is no statistical correlation between age and performance in wheelchair rugby. These findings significantly affect effective talent identification and athlete development programs. This impact ensures that athletes receive the necessary support to reach their maximum potential while avoiding the pitfalls of underestimating or overestimating their stages of development.
Performance of the 2019 American College of Rheumatology/European League Against Rheumatism Classification Criteria for IgG4-Related Disease in a Latin American Cohort
Authors: Martín-Nares Eduardo , Hernández-Molina Gabriela , Baenas Diego Federico , Delgado de la Mora Jesús , Caeiro Francisco , Wurmann Kiblisky Pamela , Pimentel-Quiroz Victor R. , Ascuña Valdivia Valery , Faz-Munoz David , Saad Emanuel José , Cairoli Ernesto , Elgueta Pinochet Sergio , Madariaga Charaja Hugo , Montante-Montes de Oca Daniel , Gallo Jesica Romina , Ugarte-Gil Manuel F. , Neira Oscar , Burgos Paula I. , Paira Sergio ,   Grupo Latino Americano de Estudio de la Enfermedad Relacionada a IgG4 (GLAER-IgG4)
Published: January 2024

Background/ObjectiveThe 2019 American College of Rheumatology/European League Against Rheumatism Classification Criteria (2019 AECC) for IgG4-related disease (IgG4-RD) is considered a significant advancement in the study of this condition. Most studies evaluating their performance have focused on White and Asian patients, leaving a knowledge gap regarding Latin American populations. Therefore, this study aimed to assess the performance of the 2019 AECC for IgG4-RD in a cohort of Latin American patients.MethodsA multicenter medical records review study was conducted, involving centers from Argentina, Chile, Mexico, Peru, and Uruguay. Data on IgG4-RD patients and mimicker conditions were collected through a standardized online form. The criterion standard for diagnosing IgG4-RD was based on the fulfillment of the Comprehensive Diagnostic Criteria for IgG4-RD and/or the Consensus Statement on Pathology. The 2019 AECC was retrospectively applied.ResultsWe included 300 patients, with 180 (60%) having IgG4-RD and 120 (40%) having mimicker conditions. The 2019 AECC had a sensitivity of 66.7% and a specificity of 100%. Sensitivity increased to 73.3% when disease-specific autoantibody items were removed, without affecting specificity. The true-positive cases had more involved organs, a higher availability of biopsy results, and were more likely to belong to the Mikulicz/systemic and proliferative phenotypes.ConclusionsThe use of the 2019 AECC for IgG4-RD in a Latin American population confirms its high specificity in excluding those without the disease. The presence of concomitant autoimmune diseases and clinically nonsignificant disease-specific autoantibodies excludes a significant number of patients from fulfilling the criteria.
Rim4 is a Thermal Sensor and Driver of Meiosis-specific Stress Granules
Authors: Zhang Rudian , Li Shunjin , Feng Wenzhi , Qian Suhong , Chellappa Akshay John , Wang Fei 
Published: January 2024

AbstractRim4 is a meiosis-specific RNA-binding protein (RBP) that sequesters mRNAs to suppress their translation. Previous work has defined the Rim4 C-terminal low-complexity domain (LCD) as sequences that form self-propagating amyloid-like aggregates. Here, we uncovered a dynamic and reversible form of Rim4 self-assembly primarily triggered by heat during meiosis, proportionally from 30°C to 42°C. The formed thermal Rim4 condensates in cell promptly stimulates stress granule (SG) assembly, recruiting SG-resident proteins, such as Pab1 and Pbp1, and strikingly, decreases the required temperature for meiotic SG formation (∼33°C) by ∼9°C as compared to mitosis (∼42°C). This sensitization of meiotic SG formation to heat effectively prevents meiosis progression and sporulation under harmful thermal turbulence. Meanwhile, the Rim4-positive meiotic SGs protect Rim4 and Rim4-sequestered mRNAs from autophagy to allow a rapid recovery from stalled meiosis upon the stress relief. Mechanistically, we found that the yeast 14-3-3 proteins (Bmh1 and Bmh2) and nucleic acids brake initiation of heat-induced Rim4 self-assembly, and Hsp104 facilitates the restoration of intracellular Rim4 distribution during the recovery.
Topographic variation in neurotransmitter receptor densities explains differences in intracranial EEG spectra
Authors: Stoof U.M. , Friston K.J. , Tisdall M. , Cooray G.K. , Rosch R.E. 
Published: January 2024

AbstractNeurotransmitter receptor expression and neuronal population dynamics show regional variability across the human cortex. However, currently there is an explanatory gap regarding how cortical microarchitecture and mesoscopic electrophysiological signals are mechanistically related, limiting our ability to exploit these measures of brain (dys)function for improved treatments of brain disorder; e.g., epilepsy.To bridge this gap, we leveraged dynamic causal modelling (DCM) and fitted biophysically informed neural mass models to a normative set of intracranial EEG data. Subsequently, using a hierarchical Bayesian modelling approach, we evaluated whether model evidence improved when information about regional neurotransmitter receptor densities is provided. We then tested whether the inferred constraints — furnished by receptor density — generalise across different electrophysiological recording modalities.The neural mass models explained regionally specific intracranial EEG spectra accurately, when fitted independently. Incorporating prior information on receptor distributions, further improved model evidence, indicating that variability in receptor density explains some variance in cortical population dynamics. The output of this modelling provides a cortical atlas of neurobiologically informed intracortical synaptic connectivity parameters that can be used as empirical priors in future — e.g., patient specific — modelling, as demonstrated in a worked example (a single-subject mismatch negativity study).In summary, we show that molecular cortical characteristics (i.e., receptor densities) can be incorporated to improve generative, biophysically plausible models of coupled neuronal populations. This work can help to explain regional variations in human electrophysiology, may provide a methodological foundation to integrate multi-modal data, and might serve as a normative resource for future DCM studies of electrophysiology.Significance StatementUnderstanding the link between measures of brain function and their underlying molecular and synaptic constraints is essential for developing and validating personalised, pharmacological interventions. But despite increasing availability of detailed normative datasets of human brain structure and function — across modalities and spatial scales — translating between these remains challenging.Using two large normative datasets — intracranial EEG recordings and autoradiographic receptor density distributions — we demonstrate that generative models of these data can link structure to function. Specifically, we show that regional oscillatory neuronal population activity is shaped by the distribution of neurotransmitter receptors. This modelling furnishes an atlas of normative parameter values, which can provide neurobiologically informed priors for in-silico (e.g., Digital Twin) characterisation of normal and disordered brain functioning.