bluuebunny/crossref_metadata_2025_split huggingface dataset:
Antral Follicle Responsiveness to Follicle Stimulating Hormone Administration Assessed by the Follicular Output Rate (FORT) May Predict In Vitro Fertilization-Embryo Transfer Outcome
Authors: Seadawy Maged EL , Abou-Sunna Hesham Fekry , Abbas Ahmed Altaf 
Published: January 2024

Abstract
Objectives: In search of a qualitative indicator of ovarian function, we sought to determine if antral follicles' reproductive competence is correlated with their Follicular Output Rate (FORT), which indicates how sensitive they are to FSH administration.
Design: Prospective Cohort study.
Setting: In a private IVF unit.
Patients: From January 2014 to June 2015, we examined 300 IVF-ET candidates, aged between 20 and 35, who had undergone controlled ovarian hyper-stimulation with comparable beginning levels of FSH and had primary infertility without apparent cause.
Method: Antral follicle (3–8 mm) count (AFC) and pre-ovulatory follicle (18–24 mm) count (PFC) were performed, respectively, at the achievement of pituitary suppression (before FSH treatment) and on the day of hCG administration. The FORT was calculated by PFC × 100/AFC. FORT groups were set according to tercile values: low (4.3%; n = 13), average (30.7%; n = 92) and high (65%; n = 195).
Main outcomes: Clinical pregnancy rate
Results: The odds ratio for clinical pregnancy increases with increasing endometrial thickness, number of collected oocytes, and follicular output rate, with odds ratios of 1.123, 1.121, and 1.312, respectively.
Conclusion: The observed association between IVF-ET result and the proportion of antral follicles attaining pre-ovulatory maturity that successfully react to FSH injection shows that FORT may be a qualitative mirror of ovarian follicular competency. More research with broader inclusion criteria and more tailored techniques is required to verify these findings.
Exploring Requirements for the Development and Implementation of VR Rehabilitation Programs for Long/Post COVID Patients – A Qualitative Mixed-Methods Study
Authors: Dalko Katharina , Elsuson Hlynur Andri , Hofstetter Sebastian , Stoevesandt Dietrich , Paulicke Denny , Helm Jürgen 
Published: January 2024

Abstract
An essential step to address persistent symptoms of Long/Post COVID patients lies in the implementation of flexible and accessible respiratory rehabilitation programs. Currently, access to rehabilitation is limited by a lack of available services as well as the physical impairments of those affected by the disease. Virtual reality technologies (VR) offer the potential to support traditional therapies with individualized at home programs. Initial findings on respiratory VR rehabilitation show that the usability and practical applicability of digital programs play an important role in the successful implementation. This study therefore evaluates physiotherapy implemented by a VR application as part of a co-creative, iterative development process with the aim of ensuring usability and acceptance by patients and physiotherapists. Further, requirements for the practical implementation of respective programs as well as the specific needs of the user groups were investigated. Physiotherapists and Long/Post COVID patients evaluated a VR prototype at five stages of development. Feedback was gathered via focus groups and expert interviews. Results then contributed to the further development of the application until relevant requirements for the development of a final prototype could be defined. Overall, it was found that the immersive VR-supported training sessions were well received by patients. However, obstacles which primarily relate to a lack of digital literacy and adverse effects were also reported. Accordingly, prerequisites such as training and technical support for the user groups as well as a target group-oriented design of the applications are necessary for VR rehabilitation to be accepted.
Development and validation of a prognostic nomogram based on the log odds of positive lymph nodes (LODDS) for parotid gland cancer
Authors: Ma Yaping , Wang Liyuan , Ji Ping , Li Qingshu 
Published: January 2024

Abstract

Objective
The focus of this research was to explore the predictive usefulness of the logarithm ratio of positive lymph nodes (LODDS) in patients with parotid gland tumors and try to develop a clinical prognosis model.
Methods
A total of 924 patients with n1/n2 stage parotid tumors were retrospectively studied. The researchers looked at the link between clinicopathological characteristics, AJCC N stage, LODDS, and overall survival (OS). The association between overall survival and numerous variables was investigated using Cox regression, and a clinical prediction model was developed. In addition, the likelihood ratio (LR), Harrell consistency index (C index), area under the curve of receiver operating characteristic (ROC-AUC) and Akaike information criteria were used to assess the model's prediction ability (AIC).
Results
The ideal LODDS cutoff value was − 0.56 based on a training set of 645 patients. Patients' age, tumor size, T stage, radiation, and LODDS were all found to be independent factors affecting their survival in a Cox multivariate analysis. After examination, the prediction model based on effective prognostic parameters performed well: LR = 154.4, AIC = 4045.1, CI = 0.693 and ROC-AUC of 3-5-7 years: 0.744, 0.752, 0.815, which outperformed AJCC TNM model; DCA curve shows higher clinical practicability. Consistent results were obtained in the validation cohort of 278 patients.
Conclusion
In patients with parotid tumor, LODDS is an independent prognostic factor, and those with LODDS less than − 0.56 had a better prognosis. The established prediction model and nomogram demonstrate outstanding prediction performance as well as broad applicability.
Investigation of the Effect of Phenylboronic Acid on Androgen-Dependent (LNCaP) and Androgen-Independent (PC3) Prostate Cancer Cells via MAP Kinases by 2D and 3D Culture Methods
Authors: Gürgen Duygu Gürsoy , Güneş Arzu , Köse Oğuzhan , Kaplan Arife Ahsen , Tunalı M. Başak , Keskin İlknur 
Published: January 2024

Abstract

Background
The castration process is able to regress prostate cancer due to its dependence on androgen. After castration, the disease could progress androgen independently. In our study, two prostate cancer cell lines PC3, LNCaP, and normal prostatic epithelial cell line RWPE-1 were used. PBA an essential compound found in nature, was selected as a chemotherapeutic to examine the effects of microtubule-targeted therapy in human prostate cancer. Colchicine, which belongs to the same class of chemotherapeutics, was included in the study as a positive control treatment. The aim of this study examine the cytotoxic effect of PBA on LNCaP, PC-3, and RWPE-1 cells with two different cell culture methods.
Methods
The IC50 values treated to the cells following the viability analyses were performed for PBA and Colchicine in 2D and 3D culture models. Colony formation, proliferation, and migration analyses were performed on prostate cancer cells, and chemotherapeutics’s effects were compared.
Results
In both cancer cell lines, 48 hours of PBA treatment inhibited migration greater than Colchicine. Colony formation analysis showed that the 24 hours PBA treatment prevented the formation. In addition, it was determined that PBA caused a decrease in proliferation parameters in both culture models. The MAPK cellular response induced by PBA was examined by immunofluorescence intensity analysis of kinase proteins of the MAPK pathway, where statistically significant differences were observed between the groups. ERK expression ratio varied in two culture methods, chemotherapeutics, and treatment times. In the 2D culture model, 24 hours of PBA treatment caused a decrease in JNK expression in PC3 and LNCaP cells. Both chemotherapeutic treatments resulted in an increase in p38 expression ratio in PC3 spheroids. On the semi-thin sections, the morphological deformation effect of PBA on cancer cells was pronounced. Morphological defects caused by PBA were first visualized in this study at the ultrastructural level.
Conclusion
Antimitotic chemotherapeutics may trigger different metabolic responses and also divergences in the signaling mechanisms within different cells. PBA has an anticancer effect potential including inhibiting proliferation and migration. The lower toxicity of PBA on RWPE-1 is remarkable for being a potential chemotherapeutic option in future research.
Association between women's empowerment and modern contraception uptake in Bangladesh: Evidence from Bangladesh Demographic and Health survey
Authors: Kabir Md Awal , Alam Md Badsha , Khanam Shimlin Jahan , Hassen Md Tahir , Khan Md Nuruzzaman 
Published: January 2024

Abstract
Background
While women's empowerment is recognized as a significant factor influencing maternal and child health outcomes, there is insufficient evidence regarding its link with the utilization of modern contraceptive methods in Bangladesh. This study aims to investigate the association between women's empowerment and the uptake of modern contraceptives among reproductive-aged women in Bangladesh.
Methods
Data of 17,780 married reproductive-aged women were analyzed from the 2017/18 Bangladesh Demographic and Health Survey. The outcome variable considered was the uptake of modern contraceptive methods (yes, no). Women’s empowerment (not empowered, moderately empowered, highly empowered) was considered the major explanatory variable. The variable was generated based on women’s responses to three key areas: access to healthcare, significant household purchases, and visits to family or relatives. A multilevel mixed-effect logistic regression model was used to assess the association between the outcome and explanatory variables, adjusted for covariates.
Results
The reported prevalence of modern contraceptive method use was 55.3%, and 51.6% among all women and women who were not empowered, respectively. Women classified as not empowered had a 13% (aOR 0.87, 95% CI: 0.79–0.97) reduced odds of using modern contraceptive methods compared to those who were highly empowered. Women who made joint decisions with their husbands on individual dimensions of empowerment consistently showed a higher likelihood of using modern contraceptive methods.
Conclusion
The findings of this study emphasize the significance of collaborative decision-making to enhance the uptake of modern contraception. Family planning policies and programs should prioritize addressing this issue.
Enhanced Semi-supervised Relation Extraction Based on Label Confusion Learning and Multisource Semantic Aggregation
Authors: Zhang Lei , Zhou Xiang , Yang Chengwei , Ding Xin , Wei Chuyuan 
Published: January 2024

Abstract
Knowledge Graph (KG) plays a significant role in the field of artificial intelligence. The search engines, intelligent recommendations, and various other domains such as architecture, finance, and healthcare rely on KG. KG is widely utilized to support decision-making and information retrieval. Relation Extraction(RE) is a crucial technique in constructing the KG. Traditional RE based on supervised learning demand a substantial amount of manually annotated data, leading to long processing times and high costs. The methods based on remote supervision and semi-supervised learning has the problem of label noise. To address these challenges, this paper proposes an innovative semi-supervised learning approach to model the relationships between labels and instances, and utilizes a novel label distribution to supervise model training. Additionally, by integrating entity location information and label information, the information of context representation is enriched. Extensive experiments on SemEval datasets prove that the proposed method outperforms the existing approaches.
Association of clinical indicators of acute deterioration and morbidity and mortality in the residential aged care population: a retrospective cohort study of routinely collected health data (interRAI-LTCF New Zealand)
Authors: Daltrey Julie , Boyd Michal , Burholt Vanessa , McLeod Heather , Wu Zhenqiang , Bloomfield Katherine , Robinson Jacqualine 
Published: January 2024

Abstract
Background: The timely identification of acute deterioration in people living in residential aged care is critical to avoiding or reducing rates of adverse events such as Emergency Department (ED) presentation or hospitalisation or death. This task is difficult as advanced age, multiple morbidity and frailty cause atypical or non-specific presentations of ill health. This study aimed to quantify the association between clinical indicators of acute deterioration reported in the literature and adverse events in his population.
Method: A retrospective cohort study using routinely collected health data. The cohort (n=5238) were aged 65 years or older in their last year of life and had an interRAI-LTCF assessment completed (I January to 31 December 2015). InterRAI-LTCF variables were matched with clinical indicators of acute deterioration reported in the literature. Univariate and multivariate logistic regression tested the association between those variables and ED presentation, hospitalisation or death 7 days or less from last completed interRAI-LTCF assessment.
Results: Nine clinical indicators, from four health domains were independently associated with acute deterioration. Cognitive indicators were being ‘largely asleep or unresponsive’odds ratio (OR) 7.95 95% CI 4.72-13.39, p<.001 and being ‘easily distracted; different to usual’ (OR 1.78 95% CI 1.28-2.49, p<.001). In the behavioural domain, eating ‘one or fewer meals a day’ (OR 2.13 95% CI 1.67-2.73, p<.001) and functional domain, a decline in activities of daily living status (OR 2.06 95% CI 1.11-3.82, p = .02) and not transferring to the toilet in the last three days (OR 1.95 95% CI 1.24-3.03, p = .004) were significant. Physical domain indicators were ‘dyspnoea; at rest’ (OR 1.81 5% CI 1.32-2.49, p<.001), ‘two or more falls in last 30 days’ (OR 1.53 95% CI 1.15-2.03, p = .003), daily peripheral oedema (OR 1.37 95 CI 1.07-1.77, p = .014) and daily pain (OR 1.37 95% CI 1.05-1.77, p = .019).
Conclusion and implication: Clinical indicators of acute deterioration reported in the literature are significantly associated with adverse events. This evidence is a first step towards the future development of tools to support residential aged care staff with the identification of acute deterioration.
Practice of cardioversion in a community hospital: feasibility, safety and immediate effectiveness
Authors: Okhotin Artemiy , Barchuk Anton , Osipov Vasiliy , Osipov Maxim 
Published: January 2024

Abstract
Background. Atrial fibrillation is the most prevalent sustained cardiac arrhythmia. Direct current cardioversion, a well-established part of the rhythm control strategy, is probably underused in community settings. Here, we describe its use, safety, and effectiveness in a cohort of patients with atrial fibrillation treated in rural settings.
Methods. It is a retrospective cohort study. Data on all procedures from January 1, 2016, till December 1, 2022, in Tarusa Hospital, serving mostly a rural population of 15,000 people, were extracted from electronic health records. Data on the procedure's success, age, gender, body mass index, comorbidities, previous procedures, echocardiographic parameters, type and duration of arrhythmia, anticoagulation, antiarrhythmic drugs, transesophageal echocardiography, and settings were available.
Results. Altogether, 1251 procedures in 430 patients were performed during the study period. The overall effectiveness of the procedure was 92\%. Effectiveness was similar across all prespecified subgroups. Direct current cardioversion was slightly less effective in patients undergoing the procedure for the first time (87%, 95% CI: 83--90 vs. 95%, 95% CI: 93--96 for repeated procedures). Complications were encountered in 15 (1.2%) procedures but were not serious.
Conclusions. Direct current cardioversion is an immediately effective procedure that can be safely performed in community hospitals in outpatient settings.
Phyto-fabrication of Cobalt Oxide Nanoparticles from Ocimum Gratissimum L. Leaf and Flower Extracts and their Antimicrobial Activities
Authors: Abdi Mohammed , Yusuf Zekeria , Sasikumar J. M. 
Published: January 2024

Background:
Phyto-fabrication of nanoparticles has gained attention in recent times owing to its simple mode, cost-effective and eco-friendly nature.

Objective:
Hence, the present study aimed to synthesize cobalt oxide nanoparticles from methanol extracts of Ocimum gratissimum flower and leaf and to evaluate their antimicrobial action towards pathogenic bacteria and fungi.

Methods:
Phyto-fabrication of Cobalt nanoparticles (CoONPs) was achieved using cobalt chloride hydrate solution as a precursor. Characterization of fabricated CoONPs was performed using Ultra Violet-Visible spectrometry (UV-Vis), X-ray diffractometer (XRD), and Fourier Transform-Infrared spectroscopy (FTIR). The antimicrobial property was tested against two bacteria (Staphylococcus aureus and Escherichia coli) and two fungi (Cryptococcus albidus and Candida globasa) by agar disc diffusion technique and by measurement of Minimum Inhibitory Concentration (MIC).

Results:
Initial confirmation of CoONPs synthesis was observed by the colour change from light pink to reddish pink. Further, the UV-Vis spectrophotometry validated the CoONPs synthesis with a peak at 509 nm. The XRD authenticated the crystal nature of CoONPs synthesized using flower extract at 2θ angles with an average size of 54.9 nm and CoONPs fabricated using leaf extract at 2θ angles with an average size of 55.02 nm. The FTIR spectroscopy confirmed the functional groups present in plant extracts, which are believed to reduce and stabilize CoONPs. The findings of antibacterial activity showed that CoONPs synthesized using leaf showed a higher inhibition zone against E. coli (20.00 ± 2.00 mm) than S. aureus. Relating to fungi, the CoONPs fabricated using flower extract displayed significantly the highest activity against C. albidus (28.67±0.57 mm) and C. globasa (25.0 ± 0.00 mm). The lowest MIC was observed against S. aureus (MIC 7.5 µg/ml). For fungi, the smallest MIC was found against C. albidus (MIC 2.5 μg/ml).

Conclusion:
The current research established the efficacy of the phytochemical constituents of leaf and flower extracts of O. gratissimum for the enhancement of the effectiveness of CoONPs against both the tested bacteria and fungi.
Assessment of Causes Affecting Progress Schedules on Construction Investment Projects Funded by State Budget in Hanoi City, Vietnam
Authors: Hai Dinh Tuan 
Published: January 2024

Background:
Hanoi, the capital city, is the economic, political, and cultural center of Vietnam. Every year, the City’s Government always spends a large part of the budget on construction investment in order to create a basis for promoting its economic development and improving the residents living standards. However, in the process of implementing investment and construction, many projects were delayed, leading to the failure to achieve the desired investment efficiency.

Objective:
To research and evaluate the causes affecting the progress schedules of construction projects using public investment capital in Hanoi, the authors conducted a survey and used the F-AHP method to analyze data collected data in order to obtain objective and accurate results on the research problem.

Methods:
The causes affecting the progress of construction projects are classified into four groups, including subjective causes from project participants and objective reasons.

Results:
The results show that the causes of the project participants have a stronger influence than the objective causes in which the causes related to the owner and the causes related to the contractor have the highest influence.

Conclusion:
Based on projects ‘ progress schedules, the resources are mobilized, the parties work together to promote the development of the project.
The Magnitude and associated factors of Helicobacter Pylori Infection among Dyspeptic Patients at the Arba Minch General Hospital in Southern Ethiopia
Authors: Alelign Dagninet , Furo Goshu , Degu Maykil , Tadesse Dagimawie , Kayta Gebre , Kidanewold Aschalew 
Published: January 2024

Background:
Infection with Helicobacter pylori (H. pylori) is a major public health problem, with a higher prevalence reported in developing countries, including Ethiopia. Persistent H. pylori infection could result in chronic gastritis, duodenal ulcers, and subsequently gastric carcinoma. However, the burden of the infection varies within and between countries.

Methods:
An institution-based cross-sectional study was carried out on 422 adult dyspeptic patients attended at Arba Minch General Hospital from March 1st to June 30th, 2022. Pretested structured questionnaires were used to collect socio-demographic characteristics, clinical information, and other related factors for H. pylori infection. Stool samples were analyzed using the H. pylori fecal antigen rapid test kit. The data was analyzed using SPSS version 25. The p-value < 0.05 was considered statistically significant.

Results:
The overall magnitude of H. pylori was found to be 32.2% (136/422), with a 95% CI = (27.7-36.5). The highest proportion of H. pylori occurred in male study participants (55.1%) and in participants aged 31-40 years (42.6%). H. pylori stool antigen positivity was significantly associated with alcohol consumption [AOR = 1.87, 95% CI: (1.06-3.29)], smoking cigarettes [AOR = 2.75, 95% CI: (1.43-5.27)], and hand washing practice after the toilet [AOR = 3.02, 95% CI: (1.41-6.48)].

Conclusion:
Overall, a considerable magnitude of H. pylori was identified in the setting. Alcohol consumption, smoking cigarettes, and hand washing practice after using the toilet were found to be statistically significantly associated with H. pylori infection. Health education is therefore essential, particularly regarding societal lifestyle changes and knowledge of the potential sources of infection and H. pylori transmission.