bluuebunny/crossref_metadata_2025_split huggingface dataset:
New C—C Coupling Reaction of Cyclic Nitronates with Carbon Nucleophiles. Umpolung of the Conventional Reactivity of Nitronates.
Authors: Smirnov Vladimir O. , Ioffe Sema L. , Tishkov Alexander A. , Khomutova Yulia A. , Nesterov Ivan D. , Antipin Michael Yu. , Smit William A. , Tartakovsky Vladimir A. 
Published: April 2005

AbstractFor Abstract see ChemInform Abstract in Full Text.
A General Approach to Selective Functionalization of 1,2,4‐Triazines Using Organometallics in Palladium‐Catalyzed Cross‐Coupling and Addition Reactions.
Authors: Alphonse France‐Aimee , Suzenet Franck , Keromnes Anne , Lebret Bruno , Guillaumet Gerald 
Published: April 2005

AbstractFor Abstract see ChemInform Abstract in Full Text.
Synthesis and Spectral Characterization of Diethyl 2‐[Aryl(4‐aryl‐1,2,3‐selenadiazol‐5‐yl)methyl]malonate.
Authors: Saravanan Sivaperuman , Muthusubramanian Shanmugam 
Published: April 2005

AbstractFor Abstract see ChemInform Abstract in Full Text.
Stannylative Cycloaddition of Enynes Catalyzed by Palladium—Iminophosphine.
Authors: Nakao Yoshiaki , Hirata Yasuhiro , Ishihara Shinjiro , Oda Shinichi , Yukawa Tomoya , Shirakawa Eiji , Hiyama Tamejiro 
Published: April 2005

AbstractFor Abstract see ChemInform Abstract in Full Text.
Antiinflammatory Triterpenoid Saponins from the Seeds of Aesculus chinensis.
Authors: Wei Feng , Ma Lin‐Yun , Jin Wen‐Tao , Ma Shuang‐Cheng , Han Guo‐Zhu , Khan Ikhlas Ahmad , Lin Rui‐Chao 
Published: April 2005

AbstractFor Abstract see ChemInform Abstract in Full Text.
Two New Monoterpene Glycosides and Trypanocidal Terpenoids from Dracocephalum kotschyi.
Authors: Saeidnia Soodabeh , Gohari Ahmad Reza , Uchiyama Nahoko , Ito Michiho , Honda Gisho , Kiuchi Fumiyuki 
Published: April 2005

AbstractFor Abstract see ChemInform Abstract in Full Text.
Bioactive Constituents from Chinese Natural Medicines. Part 14. New Glycosides of β‐Carboline‐Type Alkaloid, Neolignan, and Phenylpropanoid from Stellaria dichotoma L. var. lanceolata and Their Antiallergic Activities.
Authors: Morikawa Toshio , Sun Bohang , Matsuda Hisashi , Wu Li Jun , Harima Shoichi , Yoshikawa Masayuki 
Published: April 2005

AbstractFor Abstract see ChemInform Abstract in Full Text.
New Insecticidal Amides from Petroleum Ether Extract of Dried Piper nigrum L. Whole Fruits.
Authors: Siddiqui Bina Shaheen , Gulzar Tahsin , Mahmood Azhar , Begum Sabira , Khan Bushra , Afshan Farhana 
Published: April 2005

AbstractFor Abstract see ChemInform Abstract in Full Text.
In Searching for New Antiinfluenza A Drugs: Heterocyclic and Carbocyclic Aminoadamantanes Bearing a 2‐Adamantyl Group with Potent Activity Against Influenza A Virus
Authors: Kolocouris N. , Kolocouris A. , Foscolos G. B. , Fytas G. , Padalko E. , Neyts J. , De Clercq E. 
Published: April 2005

AbstractFor Abstract see ChemInform Abstract in Full Text.
Novel Chiral Molecular Tools for Preparation of Enantiopure Alcohols by Resolution and Simultaneous Determination of Their Absolute Configurations by the 1H NMR Anisotropy Method
Authors: Kasai Yusuke , Naito Junpei , Kuwahara Shunsuke , Watanabe Masataka , Ichikawa Akio , Harada Nobuyuki 
Published: April 2005

AbstractFor Abstract see ChemInform Abstract in Full Text.
Stereoselective kinetic study of hexaconazole enantiomers in the rabbit
Authors: Wang Qiu Xia , Qiu Jing , Wang Ping , Jia Gui Fang , Wang Peng , Li Jun Ling , Zhou Zhi Qiang 
Published: April 2005

AbstractHexaconazole [(RS)‐2‐(2,4‐dichlorophenyl)‐1‐(1H‐1,2,4‐triazol‐1‐yl)hexan‐2‐ol] is a potent triazole fungicide. The (−) isomer accounts for most of the fungicidal activity. The stereo‐ and/or enantioselective kinetics of hexaconazole were investigated in rabbits by intravenous injection. The concentrations of (−)‐ and (+)‐hexaconazole in plasma, liver, and kidney tissue were determined by HPLC with a cellulose tris(3,5‐dimethylphenylcarbamate)‐based chiral stationary phase and by gas chromatography–mass spectrometry. After intravenous administration of racemic hexaconazole (rac‐hexaconazole) at 30 mg/kg, plasma, liver, and kidney levels of the (+)‐enantiomer decreased more rapidly than those of the (−)‐enantiomer. The (−)‐/(+)‐enantiomer ratio of the area under the concentration–time curve (AUC0–∞) was 1.35. The total plasma clearance value (CL) of (+)‐enantiomer was more than 1.3‐fold higher than that of the (−)‐hexaconazole. The enantiomeric ratio (ER) increased with time in plasma, liver, and kidney. Other pharmacokinetic parameters of the enantiomers were also different. These results indicate substantial stereoselectivity in the kinetics of hexaconazole enantiomers in rabbits. Chirality 17:186–192, 2005. © 2005 Wiley‐Liss, Inc.
Binding of hela spectrin to a specific hela membrane fraction
Authors: Mangeat Paul H. , Burridge Keith 
Published: April 2005

AbstractFrom 30–40 g of Hela‐S3 cells grown in suspension, 0.25–0.50 mg of spectrin has been purified by conventional biochemical procedures starting from a low ionic strength extraction at alkaline pH of crude Hela membranes. Hela spectrin consists in its native form of a tetramer α2β2 of two high molecular weight polypeptides (240,000 and 230,000 daltons). Three different populations of Hela membranes depleted of both spectrin and actin have been prepared on discontinuous sucrose gradients. Surprisingly, spectrin will reassociate with only the heavier membrane fraction. This reassociation is specific for Hela spectrin, since three other purified Hela proteins as well as human erythrocyte spectrin do not reassociate under the same conditions. This binding is not due to the presence of traces of actin still present in the membrane fraction since two Hela actin‐binding proteins (filamin I and II) do not show any significant binding to this fraction. The nature of the membrane‐binding site for Hela spectrin is discussed.
Ca2+‐Regulated actin and phospholipid binding protein (68kD‐protein) from bovine liver: Identification as a homologue for annexin VI and intracellular localization
Authors: Hosoya Hiroshi , Kobayashi Ryoji , Tsukita Shoichiro , Matsumura Fumio 
Published: April 2005

AbstractAn F‐actin binding protein was purified from bovine liver by means of DNase I affinity, hydroxylapatite and DEAE‐cellulose column chromatographies. It consisted of a single polypeptide chain having an apparent molecular weight of 68,000 with a Stokes radius of 35Å. Electron microscopy of rotary shadowed specimens showed that the 68kD protein is a globular protein. This protein showed a higher affinity for F‐actin in the presence of Ca2+ than in its absence, which is opposite to the actin‐binding property shown by nonmuscle alpha‐actinin or fimbrin. The 68kD protein had no F‐actin severing and capping activity. Interestingly, the 68kD protein was found to aggregate liposomes at micromolar Ca2+ concentrations. Immunoblot analysis and partial protein sequence data identified the 68kD protein as an annexin VI (p68) homologue. Immunocytochemical studies showed that the 68kD protein was localized along stress fibers as well as membrane ruffles, microspikes and focal contacts, raising the possibility that annexin VI may contribute to control membrane‐microfilament interaction in the cell. © 1992 Wiley‐Liss, Inc.
Hypofractionated three‐dimensional conformal radiation therapy for primary liver carcinoma
Authors: Liang Shi‐Xiong , Zhu Xiao‐Dong , Lu Hai‐Jie , Pan Chao‐Yang , Li Fu‐Xiang , Huang Qi‐Fang , Wang An‐Yu , Chen Long , Fu Xiao‐Long , Jiang Guo‐Liang 
Published: April 2005

AbstractBACKGROUNDThe purpose of the current study was to evaluate the tolerance and efficacy of hypofractionated three‐dimensional conformal radiotherapy (3DCRT) with or without transarterial chemoembolization (TACE) for technically unresectable or medically inoperable primary liver carcinoma (PLC).METHODSBetween April 1999 and August 2003, 128 patients with a clinical diagnosis of PLC received hypofractionated 3DCRT at Cancer Hospital, Guangxi Medical University. Both hypofractionated 3DCRT and TACE were used to treat 48 of these 128 patients. Liver cirrhosis of Child–Pugh Grade A was found in 108 patients, and Grade B was found in 20 patients. The mean gross tumor volume (GTV) was 459 ± 430 cm3. A mean total irradiation dose of 53.6 ± 6.6Gy was delivered at an average fraction of 4.88 ± 0.47Gy, 3 times a week using 8‐MV photons.RESULTSThe median follow‐up time after 3DCRT was 12 months (range, 2–56 mos.). The immediate response rate was 55%. The overall survival rates at 1, 2, and 3 years were 65%, 43%, and 33%, respectively, with a median survival of 20 months (range, 7–31 mos.). Radiation Therapy Oncology Group (RTOG) Grade 2 acute gastrointestinal complications developed in 8 patients, whereas 4 patients developed Grade 3 late gastrointestinal complications. Radiation‐induced liver disease (RILD) developed in 19 (15%) patients, of which 12 had Child–Pugh Grade B liver cirrhosis, and 7 had Grade A. GTV and associated liver cirrhosis were identified by Cox regression analysis as independent predictors for survival (P = 0.044 and 0.015).CONCLUSIONSHypofractionated 3DCRT is effective in carefully selected patients with PLC. Gastrointestinal complications and RILD were the most distinct complications. Cancer 2005. © 2005 American Cancer Society.
A phase II trial of R115777, an oral farnesyl transferase inhibitor, in patients with advanced urothelial tract transitional cell carcinoma
Authors: Rosenberg Jonathan E. , von der Maase Hans , Seigne John D. , Mardiak Jozef , Vaughn David J. , Moore Malcolm , Sahasrabudhe Deepak , Palmer Peter A. , Perez‐Ruixo Juan Jose , Small Eric J. 
Published: April 2005

AbstractBACKGROUNDR115777 is a potent farnesyl transferase inhibitor and has significant antitumor effects in vitro and in vivo.METHODSThe objective of the current study was to determine the objective response proportion in patients with metastatic transitional cell carcinoma (TCC) of the urothelial tract who received treatment with R115777 at a dose of 300 mg orally given twice daily for 21 days followed by 7 days of rest for every 4‐week cycle. Thirty‐four patients with TCC were enrolled in this Phase II study. Patients were allowed to have received a maximum of one prior systemic chemotherapy regimen, not including chemoradiation or neoadjuvant chemotherapy. All patients were required to have an Eastern Cooperative Oncology Group performance status of 0–2 and adequate bone marrow, hepatic, and kidney function.RESULTSTwice daily administration of oral R115777 was tolerated well. R115777 was absorbed rapidly after oral administration. Grade 3–4 neutropenia (according to the National Cancer Institute Common Toxicity Criteria [version 2.0]) was observed in 5 patients (15%). Grade 3–4 nonhematologic toxicity was rare, consisting of rash and diarrhea in 1 patient each. Two patients (6%) without prior chemotherapy demonstrated partial responses. Thirteen patients (38%) achieved disease stabilization according to World Health Organization criteria that lasted a median of 4 months. No complete responses were observed.CONCLUSIONSThe objective response rate of R115777 was not sufficient to warrant future investigation in TCC as a single agent. Preliminary evidence of the activity of R115777 in 2 chemotherapy‐naïve patients may warrant further investigation in combination with first‐line chemotherapy. Cancer 2005. © 2005 American Cancer Society.
Determination of Glyphosate as cross‐contaminant in a commercial herbicide by capillary electrophoresis‐electrospray ionization‐mass spectrometry
Authors: Safarpour Hudan , Asiaie Reza 
Published: April 2005

AbstractCapillary electrophoresis combined with mass spectrometry (CE‐MS) was used for the rapid determination of the negatively charged herbicide, Glyphosate, in a selective dried granule (DG) formulation. The CE‐MS method was required to ensure product safety from the risk of cross contamination of a selective herbicide formulation. Glyphosate separation was achieved by using a bare fused‐silica capillary column, operated in the reversed‐polarity mode, using ammonium formate buffer, pH 2.5. The total CE‐MS analysis time was under 10 min and the limit of detection was 10 ng/mL. The CE‐MS analysis of Glyphosate was simple, rapid, and selective. The method involved minimal sample handling and was proven to be ideal for cross‐contamination investigations in manufacturing samples.
Behavior of trickle‐bed air biofilter for toluene removal: Effect of non‐use periods
Authors: Kim Daekeun , Cai Zhangli , Sorial George A. 
Published: April 2005

AbstractA laboratory‐scale trickle bed air biofilter (TBAB) packed with synthetic, inorganic media for microbial attachment was used for toluene removal from an air stream. Three experimental strategies—including backwashing as the active biomass control and two non‐use periods (starvation, which represents a period without toluene loading, and stagnant, which reflects no flow)—were considered in this study. The non‐use periods can be considered as another means of biomass control for low VOC loadings (0.70 and 1.41 kg COD/m3·day), whereas at high VOC loading (>3.52 kg COD/m3·day) backwashing is deemed essential to remove the excess biomass accumulation in the biofilter. As the toluene loading rate was increased, a considerably longer reacclimation period was unavoidable for biofilter performance to reach the 99% removal for all experimental strategies (backwashing, starvation, and stagnant). Because the biofilter response was strongly dependent on the active biomass in the system, biofilter response after the non‐use periods was significantly different from that after backwashing. © 2005 American Institute of Chemical Engineers Environ Prog, 2005
Magnetic tracing at Abu Sir (land of forgotten pyramids), northern Egypt
Authors: Abdallatif Tareq Fahmy , Abd‐All Esmat Mohamed , Suh Mancheol , Mostafa Mohamad Reem , El‐Hemaly Ibrahim Aly 
Published: April 2005

Abstract An Erratum has been published for this article in Geoarchaeology 20(6) 2005, 659. An integrated magnetic study was conducted at Abu Sir, a locality in northern Egypt also known as the “Land of the Forgotten Pyramids.” Two magnetic tools were applied over an area of 25,600 m2 in order to trace and detect hidden archaeological features near the Temple of the Sun. The acquisition of the magnetic data was initiated by measuring the magnetic susceptibility of the topsoil samples collected within the entire study area. This was followed by a gradiometer survey to measure the vertical gradient of the geomagnetic field over a restricted area of 14,400 m2. The magnetic susceptibility results are characterized by high values in the middle of the study area and a small extension of high values to the southwest. This pattern may indicate the presence of ritual monuments. The magnetic susceptibility measurements identified regions of interest to be targeted during the gradiometer survey. The gradiometer results revealed the existence of numerous archaeological features of different shapes and sizes composed of mud bricks. These features may represent tombs, burial rooms, and dissected walls, and all of them probably belong to the 5th Dynasty of pharaohs. The depth of the expected buried archaeological features was estimated from the gradiometer results and is about 1.2 m for deep features and 0.42 m for shallow features. © 2005 Wiley Periodicals, Inc.
Lightning strikes and prehistoric ovens: Determining the source of magnetic anomalies using techniques of environmental magnetism
Authors: Maki David 
Published: April 2005

AbstractTechniques of environmental magnetism were used to examine soil samples from a North American archaeological site in an effort to determine the source of magnetic field gradient anomalies. Testing revealed the source of one anomaly to be lightning‐induced remanent magnetization (LIRM). This anomaly had initially been identified as a possible archaeological feature, but excavations were unable to identify a visible source. LIRM appears to be a relatively common source of anomalous signal on archaeological sites and may often be misinterpreted in magnetic imagery. Thermoremanent magnetization (TRM) was also documented and quantified in soil from archaeological hearths at the site, as were changes in the ferrimagnetic mineral concentration and coercivity spectra resulting from high‐temperature enhancement within the hearths. © 2005 Wiley Periodicals, Inc.
Magnetometric investigations of stone constructions within large ancient barrows of Denmark and Crimea
Authors: Smekalova Tatyana , Voss Olfert , Smekalov Sergej , Myts Victor , Koltukhov Sergej 
Published: April 2005

AbstractTwo examples of magnetic investigations of large barrows in Denmark and Crimea (Ukraine) are presented. The magnetic field over the Danish barrows containing megalithic graves results from the superposition of many different dipole anomalies from granite boulders. The magnetic map revealed a corridor and a chamber of a barrow in Draaby, which are adjacent to a similar, previously excavated feature. A circular wall of smaller stones, which surrounds the two chambers and corridors, is clearly visible on the magnetic map. The limestone building material used for the internal construction of the Scythian barrows in Crimea is practically nonmagnetic, while the soil in these regions has a significant magnetic susceptibility (about 10−100 ×10−5 ISO). This makes it possible to identify stone structures by their negative anomalies on magnetic maps. Each of the three large barrows is surrounded by a circular negative anomaly that is 50 m in diameter. The anomaly is caused by walls (cromlechs) inside the barrows. Within each barrow, a long negative anomaly (up to −20 nT) that starts at the cromlech and leads toward the center of the barrow is an indication of a rectangular stone construction inside the barrow (side crypt). The central part of each barrow is characterized by a positive or a negative anomaly, which reflects the state of preservation of the central chamber. © 2005 Wiley Periodicals, Inc.
A methodology for rapid archaeological site documentation using ground‐penetrating radar and terrestrial photogrammetry
Authors: Lorenzo Henrique , Arias Pedro 
Published: April 2005

AbstractThis study demonstrates how a combination of ground‐penetrating radar (GPR) and terrestrial photogrammetry were used at an archaeological site in Vigo, Spain to quickly detect and document the remains of two megalithic tombs. An investigation was necessary because the tombs were uncovered during the construction of a new highway. A total station survey was conducted to develop a digital terrain model (DTM) of the study area. Then, a GPR investigation of shallow subsoil was carried out with a 900‐MHz antenna. Radar imaging enabled the mapping of two groups of very shallow reflectors, and the excavation revealed a layer of stones with some vertical gravestones at both sites. Each structure forms a megalithic tomb similar to the barrows of Western Europe. Finally, a close‐range photogrammetric study was conducted to obtain an accurate metric document. The exhaustive documentation enabled a fine‐scaled 3D reconstruction of tombs, thereby creating a detailed record of a site which no longer exists. © 2005 Wiley Periodicals, Inc.
Effect of certain bioactive plant extracts on clinical isolates of β‐lactamase producing methicillin resistant Staphylococcus aureus
Authors: Aqil Farrukh , Khan M. Sajjad A. , Owais Mohd , Ahmad Iqbal 
Published: April 2005

AbstractEthanolic extracts and some fractions from 10 Indian medicinal plants, known for antibacterial activity, were investigated for their ability to inhibit clinical isolates of β‐lactamase producing methicillin‐resistant Staphylococcus aureus (MRSA) and methicillin‐sensitive S. aureus (MSSA). Synergistic interaction of plant extracts with certain antibiotics was also evaluated. The MRSA test strains were found to be multi‐drug resistant and also exhibited high level of resistance to common β‐lactam antibiotics. These strains produced β‐lactamases, which hydrolyze one or other β‐lactam antibiotics, tested. The extract of the plants from Camellia sinensis (leaves), Delonix regia (flowers), Holarrhena antidysenterica (bark), Lawsonia inermis (leaves), Punica granatum (rind), Terminalia chebula (fruits) and Terminalia belerica (fruits) showed a broad‐spectrum of antibacterial activity with an inhibition zone size of 11 mm to 27 mm, against all the test bacteria. The extracts from the leaves of Ocimum sanctum showed better activity against the three MRSA strains. On the other hand, extracts from Allium sativum (bulb) and Citrus sinensis (rind) exhibited little or no activity, against MRSA strains. The antibacterial potency of crude extracts was determined in terms of minimum inhibitory concentration (MIC) by the tube dilution method. MIC values, of the plant extracts, ranged from 1.3 to 8.2 mg/ml, against the test bacteria. Further, the extracts from Punica granatum and Delonix regia were fractionated in benzene, acetone and methanol. Antibacterial activity was observed in acetone as well as in the methanol fractions. In vitro synergistic interaction of crude extracts from Camellia sinensis, Lawsonia inermis, Punica granatum, Terminalia chebula and Terminalia belerica was detected with tetracycline. Moreover, the extract from Camellia sinensis also showed synergism with ampicillin.TLC of the above extracts revealed the presence of major phytocompounds, like alkaloids, glycosides, flavonoids, phenols and saponins. TLC‐bioautography indicated phenols and flavonoids as major active compounds. (© 2005 WILEY‐VCH Verlag GmbH & Co. KGaA, Weinheim)
Role of white rot fungus Funalia trogii in detoxification of textile dyes
Authors: Apohan Elif , Yesilada Ozfer 
Published: April 2005

AbstractToxic and genotoxic effects of the textile dyes on organisms suggest the need for remediation of dyes before discharging them into the environment. For this reason, the ability of Funalia trogii pellets to detoxify textile dyes was investigated and evaluated. Although, textile dyes are toxic substances for many microorganisms, the pellets were able to decolorize and detoxify the azo dyes used. Astrazon Blue and Red dyes inhibit growth of F. trogii and S. aureus on solid medium in a concentration dependent manner. The toxicity of these dyes on a fungus, F. trogii and a bacterium, S. aureus was significantly decreased after pretreatment with fungal pellets. (© 2005 WILEY‐VCH Verlag GmbH & Co. KGaA, Weinheim)
Interference of laccase in determination of cellobiose dehydrogenase activity of Pleurotus ostreatus (Florida) using dichlorophenol indophenol as the electron acceptor
Authors: Saha Tanima , Chakraborty Tapas Kumar , Saha Rina , Das Nirmalendu , Mukherjee Mina 
Published: April 2005

AbstractPleurotus ostreatus (Florida), ITCC 3308 produces ∼9.0 U/ml extracellular cellobiose dehydrogenase (CDH) in cellulose medium after 7 days of growth. However, no activity could be detected if the assay was done with cellobiose as the substrate and 2,6‐dichlorophenol indophenol (DPIP) as the electron acceptor in absence of any laccase inhibitor. Kinetic study showed that Vmax/Km value was very high for rDPIP (reduced 2,6‐dichlrophenol indophenol) oxidation by laccase. Oxygen consumption rate of rDPIP oxidation by the enzyme was found to be highest among all the tested substrates. The present study indicated that rDPIP was a good substrate for laccase. Therefore, caution is needed to measure CDH activity by monitoring DPIP reduction in a system where laccase is likely to be present. (© 2005 WILEY‐VCH Verlag GmbH & Co. KGaA, Weinheim)