bluuebunny/crossref_metadata_2025_split huggingface dataset:
Transnational Islamic Movement: The Da’wah Movement of Salafism in Southeast Sulawesi
Authors: Muhammad Alifuddin  , Iye Risman , Rusnam  , Fithriyah Inda Nur Abida  
Published: January 2025

This article reports on research conducted through observations, document studies, and in-depth interviews, with several Salafi activists in Southest Sulawesi regarding the strategy of da’wah movement. Using a phenomenological hermeneutic approach, this study has revealed that the traces of salafism in Southeast Sulawesi began in 1998 when a number of Middle Eastern alumni from this area returned and became agents of spreading the idea of salafism in Southeast Sulawesi. Furthermore, the growth of Salafi communities is attributed to effective institutional management, particularly their ability to mobilize da’wah resources and establish communication with external parties. However, other Salafi communities tend to remain rigid, prioritizing stability and consistency in adhering to the manhaj sunnah.
Didelphis marsupialis como un reservorio potencial u hospedero amplificador del virus de la estomatitis vesicular, serotipo new jersey en Antioquia
Authors: Trujillo Carlos , Arboleda John 
Published: January 2025

La Estomatitis Vesicular (EV) es una enfermedad viral, aguday autolimitante que afecta principalmente bovinos, equinos yporcinos. Es producida por el virus de estomatitis vesicular (VEV), serotipos New Jersey (VEV-NJ) e Indiana (VEV-IN), que son los as importantes epidemiológicamente (1). Los estudios serológicos demuestran que VEV-NJ y VEV-IN infectan en forma natural una gran variedad de animales silvestres, que están posiblemente implicados en la coepizootiología de la EV, como hospederos portadores, mplificadores o reservorios (2).La zarigüeya (Didelphis marsupialis) es un buen candidatopara cumplir esta función, debido a que es la especie silvestremayormente capturada en zonas enzoóticas; presenta altosporcentajes de infección natural (3), resiste la antropización yademás, su comportamiento le permite interactuar condiferentes poblaciones de vectores u otros reservorios en losbosques y servir como fuente de infección para las especiesdomésticas susceptibles.
A clinical case of a patient with recurrent bladder cancer and primary multiple metachronous tumors
Authors: Semenov E. V. , Stepanov N. A. , Zukov R. A. 
Published: January 2025

In the clinical practice of an oncologist, primary multiple tumors are one of the most difficult and poorly understood problems. The treatment of patients with multiple malignancies often involves а combined treatment methods. Taking into account the possibility of detecting tumors at different stages and localizations, the doctor needs to determine such a therapeutic approach that will be directed at several oncological processes at once. The article describes a clinical case of a male patient, born in 1948, with metachronous bladder cancer, both lungs and multifocal basal cell skin cancer.The presented experience reflects the patient’s long-term observation from 2002 to 2024, during which the patient repeatedly underwent surgical and radiation treatment of tumors of various localizations. The presented clinical case shows the importance of dynamic monitoring and regular examinations by an oncologist, which allows timely verification of a recurrence of the disease or a new malignant neoplasm and achieve the best therapeutic results.
Impact of PARP inhibitor maintenance therapy after initial treatment on the efficacy of subsequent therapy in ovarian cancer: a propensity score matching analysis
Authors: Rumyantsev А. А. , Tihomirova Т.  Е. , Tsareva А. S. , Gutorov S. L. , Lud А. N. , Chernova А. P. , Tjulandin S. A. 
Published: January 2025

Introduction: progression of advanced epithelial ovarian cancer (EOC) on olaparib may diminish the efficacy of subsequent chemotherapy in recurrent disease setting. However, the impact of progression of EOC during maintenance therapy with olaparib after frontline therapy has not been well studied.Materials and methods: this retrospective study enrolled patients of BRCA / HRD + FIGO stage III–IV EOC with confirmed progressive disease after frontline treatment treated since 2014 until 2022 who either received (arm A) or not (arm B) olaparib as maintenance therapy. To ensure the balance of the compared groups during the study propensity score matching analysis was conducted (cardinality method using MatchIT package in R) with 1:1 ratio of patients in trial arms. The groups were balanced according to the presence of residual tumor after initial treatment, the duration of platinum-free interval after the frontline therapy, secondary local therapy for recurrent disease, treatment with platinum drugs for relapse and subsequent bevacizumab. The primary endpoint of the study was progression-free survival (PFS).Results: the initial population consisted of 259 patients, after the matching procedure 76 patients were enrolled in the study. The median age of patients was 48 years in the arm A and 50 years in the arm B (p = 0.989), 12 (32 %) had FIGO stage IV in both arms (p = 1.000), 25 (66 %) patients in both arms had platinum-free interval ≥ 12 months. With a median follow-up of 42.8 mo. (0.6–70.1 months) median PFS was 6.9 (95 % CI 6.2–10.6 months) and 12.2 (95 % CI 9. 6–21.3 months) in arm A and B, respectively (hazard ratio [HR] 2.89; 95 % CI 1.63–5.12; p < 0.001). Median overall survival was 23.2 months. and 68.2 mo., respectively (HR 4.15; 95 % CI 1.62–10.6).Conclusion: efficacy of subsequent chemotherapy is apparently reduced following progression of BRCA / HRD + EOC on maintenance olaparib therapy in frontline setting. Further trials should assess optimal approaches for these patients.
Comparative analysis of induction chemotherapy followed by chemoradiotherapy and concurrent chemoradiation therapy efficacy in patients with locally advanced head and neck squamous cell cancer
Authors: Stativko O. A. , Pokataev I. A. , Nosova M. V. , Sabitov E. R. , Antonova T. G. , Kuzmina E. S. , Lyadov M. A. , Dolov M. M. , Tedeeva A. K. , Kravtsov S. A , Galkin V. N. 
Published: January 2025

Treatment strategy of advanced unresectable head and neck squamous cell cancer (HNSCC) is limited to induction chemotherapy (ICT) followed by (chemo) radiotherapy (cRT) and concurrent chemoradiotherapy (CCRT). However, the role of ICT remains controversial considering the lack of overall survival benefit.The aim: to evaluate the role of induction chemotherapy in the treatment of locally advanced HNSCC.Methods: We performed a retrospective clinical study that included patients (pts) with unresectable stage III–IVa cancer of larynx, oropharynx and hypopharynx.Results: A total of 176 pts were enrolled, 84 (48 %) received CCRT with cisplatin or carboplatin and 92 (52 %) — ICT followed by cRT. Groups were well balanced by sex, tumor site, T-stage, while in group of ICT there was a significant prevalence of younger pts (p = 0.004) and pts with stage N2–3 (p = 0,03).The objective response rates (ORR) were 76 % (42 / 55) in CCRT arm (including 53 % (12 / 62) of complete responses) and 72 % (56 / 78) in ICT arm with complete response rate of 15 % (12 / 78). The ORR in ICT arm increased after the completion of CCRT up to 82 % with 53 % (33 / 62) of complete responses. The difference was not statistically significant (p = 0,7).With a median follow-up duration of 8.7 months median progression-free survival (mPFS) was 7.6 and 9.4 months (Hazard ratio (HR) 0.67, 95 % CI 0.43–1.04); 6month OS was 65.7 % and 92.8 % in CCRT and ICT groups, respectively (HR 0.51, 95 % CI 0.30–0.85, р < 0.01).Propensity score matching analysis proved the 6month OS in the ICT + cRT group to be significantly longer than in CCRT group — 97.7 % vs 66.8 %, respectively (HR = 0.28, 95 % CI 0.13–0.62, p  < 0.01).Conclusions: ICT + сRT resulted in improvement of PFS and OS compared to CCRT in pts with locally advanced HNSCC.
Expression of the human poliovirus receptor (CD155) as an unfavorable prognostic factor for the choroid melanoma
Authors: Zherka I. Yu. , Davydov D. A. , Shupilova E. P. , Mahilyanchyk A. F. , Portyanko A. S. 
Published: January 2025

Aim: to characterize CD155 expression in primary choroidal melanoma cells and determine its prognostic value for survival.Material and methods: 68 patients with primary choroidal melanoma were included. The levels and patterns of CD155 expression in tumor tissues were studied using immunohistochemical method. Regression analysis was performed to identify independent factors predicting the course of the disease.Results: in 51 % of cases, membrane expression of CD155 was registered in choroidal melanoma cells. In the group of tumors with any type of membrane expression of CD155, the signs of poor prognosis were statistically significantly more common. Membrane expression of CD155 was found to be an independent prognostic factor for the development of distant metastases according to multivariate regression analysis (RR 3.7 95 % CI 1.3–10.4, p = 0.005), as well as for death from choroidal melanoma (RR 3.2 95 %CI 1.2–8.3, p = 0.009).Conclusion: the expression patterns of CD155 in primary choroidal melanoma were studied. It was found that the presence of membrane expression of CD155 was associated with an increased risk of choroid melanoma progression by 3.7 times and death by 3.2 times.
Avelumab in combination with axitinib and nivolumab in combination with ipilimumab in the first-line treatment of metastatic renal cell carcinoma: a realworld retrospective cohort study
Authors: Tsimafeyeu I. V. , Baklanova O. V. , Chubenko V. A. , Kalpinskiy A. S. , Safina S. Z. , Lebedinets A. A. , Petkau V. V. , Olshanskaya A. S. , Myslevtsev I. V. , Zukov R. A. 
Published: January 2025

Background: Immunotherapy-based regimens, such as nivolumab plus ipilimumab (Nivo-Ipi) and avelumab plus axitinib (Ave-Axi), are standard first-line treatments for metastatic clear-cell renal cell carcinoma (mRCC) with intermediate or poor IMDC risk. Comparative real-world evidence for these regimens remains limited.Methods: This retrospective cohort study included 102 patients with mRCC treated with Nivo-Ipi (n = 51) or AveAxi (n = 51) from 2018 to 2023. Propensity score matching was used to balance baseline characteristics, including IMDC risk and comorbidities. Primary endpoints were the rate of treatment-related adverse events (TRAEs) and progression-free survival (PFS). Secondary endpoints included objective response rate (ORR) and overall survival (OS).Results: Patient characteristics were balanced across cohorts, with a median age of 63.4 years, 76 % male, and 61 % having chronic cardiovascular diseases. The rate of any grade TRAEs was similar between Nivo-Ipi and Ave-Axi (62.7 % vs. 68.6 %, respectively), as was the rate of grade ≥ 3 TRAEs (11.7 % vs. 17.6 %). Patients treated with Ave-Axi had a significantly extended PFS (15.0 vs 9.7 months; p  0,05). The median OS was not reached.Conclusions: Nivo-Ipi and Ave-Axi are effective and well-tolerated first-line therapies for mRCC in real-world settings. Ave-Axi was associated with a significantly longer PFS and a numerically higher ORR compared to Nivo-Ipi.
The Impact of Selected Components Used in Clinical Nutrition on Inflammation Caused Malnutrition- a Literature Review
Authors: Raczyńska Aleksandra , Leszczyńska Teresa , Skotnicki Piotr , Koronowicz Aneta 
Published: January 2025

Malnutrition is a disease leading to unfavourable changes. It affects 35-55% of hospitalized patients, and in the case of cancer even 40-90% of patients. Screening nutritional status allows for prevention of malnutrition, which will be an element as important as its treatment. Malnutrition in patients after severe injuries significantly increases catabolic changes. Cytokines and hormones such as epinephrine and cortisol are released, which among other things can increase energy expenditure by 50%. The effect of a properly conducted nutritional treatment is the maintenance or improvement of the nutritional status in patients whose nutrition with a natural diet is insufficient, as well as, in some cases, treatment of the underlying disease. Immunonutrition is characteristic for patients with neurological disorders or cancer. It is a regimen based on the supply of selected ingredients that have the ability to affect immunological and anti-inflammatory pathways. such substances are omega - 3 fatty acids, glutamine, arginine, nucleotides, antioxidants and prebiotic fiber.
Machine Learning-Based Prediction of Exercise Intensity Using Skin Entropy During Incremental Cycling
Authors: Du Jiawei , Hu Chenxi , Du Ning , Zhao Li , Yu Ji-Guo , Song Yafeng 
Published: January 2025

Abstract

Skin entropy, derived from skin temperature, is considered an intuitive indicator of dynamic physiological states during exercise. This study investigates the association between skin entropy and exercise intensity. Forty young males performed incremental cycling, during which physiological measurements (heart rate, oxygen consumption, pulmonary ventilation, and respiratory exchange ratio) and skin temperatures at three predetermined regions of interest (ROIs: forehead, chest, and abdomen) were recorded. Skin temperature data were transformed into entropy values, and comparative analyses were conducted to assess changes in skin temperature and entropy values at the three ROIs before and after exercise. Post-exercise, skin temperatures on the chest and abdomen significantly decreased, while the forehead remained unchanged. Conversely, entropy values at all three ROIs significantly increased after exercise. Correlation analysis revealed significant associations between skin entropy and physiological parameters, rather than temperature. Additionally, the XGBoost machine learning classification model was trained using chest and forehead entropy data to predict exercise intensity, achieving accuracies of 86.06% and 70.03%, respectively. In conclusion, skin entropy shows considerable potential as an alternative method for monitoring exercise intensity.
Dynamicasome! Comprehensive Mutational Analysis and AI-Driven Prediction of PMM2 Pathogenicity: Integrating Molecular Dynamics Simulations with Machine Learning Models
Authors: Caulfield Thomas , Islam Naeyma , Coban Mathew , Fuller Jessica , Weber Caleb , Chitale Rohit , Jussila Benjamin , Brock Trisha , Tao Cui 
Published: January 2025

Abstract

Advances in genomic medicine have accelerated the identification of mutations in disease- associated genes, but the pathogenicity of many mutations remains unknown, hindering their use in diagnostics and clinical decision-making. Predictive AI models have been generated to combat this issue, but current tools display low accuracy when tested against functionally validated datasets. We show that integrating detailed conformational data extracted from molecular dynamics simulations (MDS) into advanced AI-based models can increase their predictive power. We carried out an exhaustive mutational analysis of the disease gene PMM2 and subjected structural models of each variant to MDS. AI models trained on this dataset outperformed existing tools when predicting the known pathogenicity of mutations. Our best performing model, a neuronal networks model, was also able to predict the pathogenicity of several PMM2 mutations currently considered of unknown significance. We believe this new model will help alleviate the burden of unknown variants in genomic medicine.
H3K27me3 epigenetic mark crucial for callus cell identity and regeneration capacity
Authors: Williams Leor Eshed , Mandel Tali , Landau udi , Kaplan Tommy , Cohen Yotam 
Published: January 2025

Abstract

Plant callus cells possess a remarkable ability to regenerate organs that often differ from their respective origins or even entire new individuals. Yet, the mechanisms underlying their pluripotent state remain elusive. We propose a strategy that involves two independent mechanisms to endow callus cells with pluripotency: (1) maintaining a unique transcriptional profile, characterised by the expression of genes from diverse developmental pathways that allows rapid response to developmental cues; (2) preventing premature differentiation through H3K27 methylation-mediated silencing of key transcription factors such as WUCHEL and SPEECHLESS. This strategy relies on a mechanism to silence the pluripotency network upon regenerative stimuli, enabling a single developmental pathway to dominate. Our study reveals that the EMF2 complex, a key regulator of H3K27 tri-methylation, plays a crucial role in this process. Callus derived from the emf2 mutant, deficient in H3K27me3, exhibits severely impaired regeneration. Comparative analyses of chromatin states and transcription profiles between wild-type and emf2 calli revealed that the loss of EMF2 leads to upregulation of key transcription factors in callus, and identified the genes regulated solely by EMF2. Our findings suggest that suppressing pluripotency networks through H3K27me3 is essential for executing specific developmental programs to ensure effective regeneration.
The accessibility and inaccessibility of urban public charging station
Authors: Qian Xinwu , Gazmeh Hossein , Small Mario L. , Wang Qi , Guo Yuntao 
Published: January 2025

Abstract

Unlike refueling at gas stations, charging an electric vehicle (EV) requires significantly more time, ranging from 20 minutes to over an hour, even with the fastest chargers. This prolonged charging duration introduces unique complexities to the fundamental understanding of public charging station (PCS) accessibility, raises questions about the ongoing relevance of spatial proximity for different population groups, and highlights the need to consider amenities near PCS that users can access along their daily routines. To account for these critical distinctions, we introduce visit-based accessibility, a metric that evaluates PCS availability relative to amenities frequented during urban routine activities. Leveraging data from over 28,000 PCSs, 5.2 million points of interest (POIs), and mobility patterns from more than 35 million cell phone users across 20 major U.S. metropolitan areas, we reveal a striking mismatch between PCS locations and the spatial proximity to and the daily needs of their intended users. While existing PCSs are spatially proximate to lower-income communities, our visit-based measure reveals significant disparities, as these communities' routine activities align significantly less with PCS locations. Furthermore, when considering dwell time at nearby amenities, higher-income communities exhibit better alignment of PCSs with routine activities and longer dwell times at nearby POIs, which are also the most extensively covered by existing PCSs. Finally, our analysis reveals that experienced income and racial segregation are likely the major impedance for accessing PCSs that are spatially adjacent, which highlights a hidden social barrier where greater divergence from typical social encounters near charging infrastructure is associated with lower visit rates to PCSs. These findings underscore the necessity for targeted strategies to ensure equitable access to charging infrastructure, addressing both spatial and functional disparities to promote sustainable and inclusive urban development.
Ei24 deficiency in brown adipocytes induces severe hypothermia under cold stress independent of UCP1 activity
Authors: Lee Han-Woong , Lee Subin , Bui Thu , Nam Tae Wook , Song Yaechan , Lee Jae Hoon , Jeong Yangsik 
Published: January 2025

Abstract

Brown adipocytes facilitate non-shivering thermogenesis, which is critical for maintaining energy balance and heat production in response to environmental stimuli. Here, we delineate the physiological and biochemical role of etoposide-induced 2.4 (Ei24) in adenosine triphosphate (ATP) production and thermogenesis in brown adipocytes. We generated Ei24 adipocyte-specific knockout (EiaKO) mice that exhibited brown adipose tissue hypertrophy, lipid accumulation, and various mitochondrial abnormalities. Despite mitochondrial defects, uncoupling protein 1 (UCP1) expression and activity remained unchanged. However, those impairments caused lethal hypothermia in mice subjected to cold challenge, underscoring the key role of Ei24 in mitochondrial functions. The morphological and functional defects of EiaKO brown adipocyte mitochondria were due to compromised proton-motive force, ATP synthesis, and fatty acid oxidation. Our findings highlight the critical role of Ei24 in sustaining mitochondrial function independently of UCP1 expression and activity, emphasizing its connection between mitochondrial respiration and thermogenesis in brown adipocytes.
A codon usage-based approach for the stratification of Influenza A
Authors: Alfonsi Tommaso , Chiara Matteo , Bernasconi Anna 
Published: January 2025

Abstract

Background: Influenza A virus (IAV) is a highly adaptable pathogen that poses a significant threat to human health. Genomic surveillance of IAVs is a complex task due to its broad host range, its zoonotic potential, and rapid evolution. Strategies based on codon preference analysis have been successfully employed for the categorization of IAVs with different host specificity in the past. Hence, monitoring codon usage adaptation, where viral codon preferences align with host preferences to enhance replication efficiency, offers a promising strategy for tracking IAV and identifying significant epidemiological events.
Results: In this study, we develop a computational workflow for the analysis and stratification of IAVs based on codon usage profiles across large datasets. Using three key case studies--the 2009 H1N1 pandemic, the H7N9 epidemic in China (2013–2017), and the long-term circulation of H5N1 in domestic birds--we demonstrate the applicability of codon usage metrics for capturing patterns of viral adaptation and genomic diversification. Our approach uncovered interesting genomic features, which are not always reflected by the clade-based nomenclature. Interestingly a reduced set of amino acids and associated codons was sufficient to summarize salient patterns of IAV genomes, suggesting shared evolutionary pressures across IAV serotypes.
Conclusion: Codon usage-based stratification effectively highlighted key epidemiological events and enabled detailed comparisons of genomic features across IAV serotypes. This approach provides a scalable framework for IAV genomic surveillance, offering insights into viral evolution and adaptation. Its general applicability makes it suitable for extending to other Influenza A serotypes, particularly those for which available genomic data are limited or a reference nomenclature is not established.
Evaluation of climatic and non-climatic influence on malaria prevalence in the Upper River Region of The Gambia
Authors: Okafor Ugochinyere Agatha , D’Alessandro Umberto , Ojeh Vincent Nduka , Filho Walter Leal , Alhassah Iddisah , Yaffa Sidat 
Published: January 2025

Abstract

Despite the scale-up of intervention, malaria remains a burden in the Upper River Region of The Gambia. Climate changes and non-climatic conditions can have a substantial influence on malaria prevalence, and further affect the coverage of preventive interventions. This work aimed at exploring the different risk factors, both climatic and non-climatic, associated with malaria. A descriptive research method using a parallel mixed method approach was adopted. Using a multistage approach, 381 households were selected from the region, and primary data was collected from household heads. Descriptive statistics were performed using StataSE18, and the significant influence of environmental and socioeconomic factors was analyzed using Chi-square (Χ2). Thematic analysis for the qualitative part was carried out using Nvivo. Malaria is heavily influenced by rainfalls and floods and by some of the measured non-climatic factors. These results will provide individuals, professionals, government, and policymakers valuable information for better-targeting malaria control efforts.