bluuebunny/crossref_metadata_2025_split huggingface dataset:
Population PK/PD modeling of low‐density lipoprotein cholesterol response in hypercholesterolemic participants following administration of bococizumab, a potent anti‐PCSK9 monoclonal antibody
Authors: Wang Ellen Q. , Kaila Nitin , Plowchalk David , Gibiansky Leonid , Yunis Carla , Sweeney Kevin 
Published: November 2023

AbstractWe sought to characterize the population pharmacokinetic/pharmacodynamic (PK/PD) relationship of bococizumab (RN316/PF‐04950615), a humanized IgG2Δa monoclonal antibody that binds to secreted human proprotein convertase subtilisin kexin type 9 (PCSK9), using data derived from 16 phase I, II, and III clinical studies (36,066 bococizumab observations, 46,790 low‐density lipoprotein cholesterol [LDL‐C] measurements, 3499 participants). A two‐compartment disposition model with parallel linear and Michaelis–Menten elimination and an indirect response model was used to characterize the population PK and LDL‐C response of bococizumab. Potential model parameters and covariate relationships were explored, and visual predictive checks were used for model assessment and validation. Key covariates included the effect of anti‐drug antibodies (ADAs) on exposure through impact on clearance and bioavailability; impact of statins on bococizumab elimination (maximal rate of metabolism); and impact of statins, Asian race, and male sex on LDL‐C efficacy (maximum effect). ADAs and neutralizing ADAs did not have additional effects on LDL‐C beyond the influence on bococizumab exposure. In conclusion, the population PK/PD model adequately describes bococizumab concentration and LDL‐C efficacy. The covariate effects are consistent with the presumed mechanism of action of PCSK9 inhibitors. With increasing availability of antibody‐based therapeutics, improved understanding of the effect of ADAs and statins on bococizumab PK/PD adds to the literature and enhances our pharmacological understanding of how immunogenicity and concomitant medications may impact the PK/PD of biotherapeutics.
In Situ TEM Observation of (Cr, Mn, Fe, Co, and Ni)3O4 High‐Entropy Spinel Oxide Formation During Calcination at Atomic Scale
Authors: Yeh Yu‐Tzu , Huang Chun‐Wei , Hou An‐Yuan , Huang Chih‐Yang , Lin Yi‐Dong , Wu Wen‐Wei 
Published: November 2023

AbstractHigh‐entropy oxides (HEOs) are promising anode materials for lithium‐ion batteries (LIBs), owing to their stable crystal structure, superionic conductivity, and high capacity. In this study, the (Cr, Mn, Fe, Co, and Ni)3O4 HEO via solid‐state reaction is prepared. To improve the synthetic efficiency, it is necessary to understand the formation mechanism. Therefore, a high‐resolution transmission electron microscopy (HRTEM) is used to record information during calcination at increasing temperature. The overall formation process included MnO2 and NiO aggregation at 500 °C, followed by (Mn, and Ni)3O4 combined with Co3O4 at 600 °C to form (Mn, Co, and Ni)3O4. At higher temperatures, Fe2O3 and Cr2O3 sequentially combined with (Mn, Co, and Ni)3O4 and formed the (Cr, Mn, Fe, Co, Ni)3O4 at 900 °C. In addition, the valence‐state‐changing mechanisms and ion arrangements of (Cr, Mn, Fe, Co, and Ni)3O4 are determined using electron energy loss spectroscopy (EELS) and extended X‐ray absorption fine structure (EXAFS). This study successfully revealed the formation of HEO at atomic scale. The results provide valuable insights for improving the manufacturing process of (Cr, Mn, Fe, Co, and Ni)3O4 HEOs, which is expected to play a vital role in the development of anode materials for next‐generation LIBs.
Recent Advances in Cardiac Magnetic Resonance for Imaging of Acute Myocardial Infarction
Authors: Wang Xu , Pu Jun 
Published: November 2023

AbstractAcute myocardial infarction (AMI) is one of the primary causes of death worldwide, with a high incidence and mortality rate. Assessment of the infarcted and surviving myocardium, along with microvascular obstruction, is crucial for risk stratification, treatment, and prognosis in patients with AMI. Nonionizing radiation, excellent soft tissue contrast resolution, a large field of view, and multiplane imaging make cardiac magnetic resonance (CMR) a “one‐stop” method for assessing cardiac structure, function, perfusion, and metabolism. Hence, this imaging technology is considered the “gold standard” for evaluating myocardial function and viability in AMI. This review critically compares the advantages and disadvantages of CMR with other cardiac imaging technologies, and relates the imaging findings to the underlying pathophysiological processes in AMI. A more thorough understanding of CMR technology will clarify their advanced clinical diagnosis and prognostic assessment applications, and assess the future approaches and challenges of CMR in the setting of AMI.
Carbon efficient production of chemicals with yeasts
Authors: Vásquez Castro Evelyn , Memari Golnaz , Ata Özge , Mattanovich Diethard 
Published: November 2023

AbstractMicrobial metabolism offers a wide variety of opportunities to produce chemicals from renewable resources. Employing such processes of industrial biotechnology provides valuable means to fight climate change by replacing fossil feedstocks by renewable substrate to reduce or even revert carbon emission. Several yeast species are well suited chassis organisms for this purpose, illustrated by the fact that the still largest microbial production of a chemical, namely bioethanol is based on yeast. Although production of ethanol and some other chemicals is highly efficient, this is not the case for many desired bulk chemicals. One reason for low efficiency is carbon loss, which decreases the product yield and increases the share of total production costs that is taken by substrate costs. Here we discuss the causes for carbon loss in metabolic processes, approaches to avoid carbon loss, as well as opportunities to incorporate carbon from CO2, based on the electron balance of pathways. These aspects of carbon efficiency are illustrated for the production of succinic acid from a diversity of substrates using different pathways.
QED effects in inclusive semi-leptonic B decays
Authors: Bigi Dante , Bordone Marzia , Gambino Paolo , Haisch Ulrich , Piccione Andrea 
Published: November 2023

Abstract
We analyse in detail the QED corrections to the total decay width and the moments of the electron energy spectrum of the inclusive semi-leptonic B → Xceν decay. Our calculation includes short-distance electroweak corrections, the complete 𝒪(α) partonic terms and leading-logarithmic QED effects up to $$ \mathcal{O}\left({\Lambda}_{\textrm{QCD}}^3/{m}_b^3\right) $$
O

Λ
QCD
3

/

m
b
3

. A comprehensive numerical comparison of our results against those obtained with the Monte Carlo (MC) tool PHOTOS is presented. While the comparison indicates good overall agreement, our computation contains QED effects not included in PHOTOS and should therefore better describe photon radiation to B → Xceν as measured by the B-factories. Our calculations represent the first steps in the construction of a fully differential higher-order QED MC generator for inclusive semi-leptonic B decays.
Factors associated with urinary retention after vaginal delivery under intraspinal anesthesia: a path analysis model
Authors: Ren Hong-yan , Zhang Huan-fang , Chen Yu-yi , Luo Tai-zhen 
Published: November 2023

Abstract
Introduction and hypothesis
Women who have intraspinal anesthesia for delivery are more likely to experience postpartum urinary retention (PUR), which, if not recognized and treated promptly, can result in long-term urinary dysfunction. Many factors influencing PUR have been proposed, but no study has been conducted to investigate the relationship between them. This study is aimed at determining the influencing factors of PUR and to explore the relationship between them.

Methods
A prospective, cross-sectional survey using self-made questionnaires was conducted among 372 puerperae in a Grade A hospital in Guangzhou, China, from April to September 2022. SPSS25.0 and AMOS24.0 were used for data analysis, and a path analysis model was established to determine the relationship between the influencing factors.

Results
The incidence of PUR was 49.85%. Residence, the level of postpartum pain, and the change of postnatal urination position had a direct effect on PUR. Episiotomy and analgesic duration have both direct and indirect effects on PUR. Forceps delivery, perineal edema and oxytocin had an indirect effect on PUR. Variables could influence the occurrence of PUR by mediating the analgesic duration, episiotomy, postpartum pain level, and postnatal urination position changes.

Conclusions
This study provides an empirical model to illustrate the relationship between PUR and related factors in women who delivered under intraspinal anesthesia. In future management, more attention should be paid to women who live in cities, have higher levels of postpartum pain, longer analgesic duration, higher grade of perineal edema, and received episiotomy, forceps delivery, and oxytocin during labor.
Introduction to informatics in a Peruvian penitentiary using cs unplugged: from university to penitentiary
Authors: Díaz-León Jose Alfredo , Arbelaitz Olatz , Arruarte Ana 
Published: November 2023

AbstractWithin the field of social reintegration and re-education, this paper presents an educational experience carried out at the Iquitos Penitentiary Center, Lima, Peru, with the aim of providing an introduction to informatics to 25 inmates who volunteered to take part in the project. Twenty students and a teacher from the Scientific University of the South also in Peru, were responsible for initiating the transmission of knowledge from the university to inmates, with the collaboration and participation of the penitentiary coordinator. The main objectives of the case study were to validate both the suitability of the CS unplugged proposal and the adaptability of the L2T2L pedagogic strategy to the transmission of knowledge to adults, specifically penitentiary inmates. This strategy had been originally designed to transmit informatics knowledge from university to primary school. The validity and effectiveness of the experience was assessed using surveys. Results confirm that inmates achieved a good level of understanding when endeavoring to resolve most of the CS unplugged assignments designed for them. It was also seen that L2T2L is adaptable and valid for different scenarios other than those for which it was initially designed. Indeed, it was proven to be valid for transmitting knowledge to the prison population. Finally, it should be pointed out that the experience is easily replicable and that it brings an opportunity to introduce informatics into education programs in prisons, something which can contribute enormously to social reintegration and re-education, facilitating the subsequent reentry of inmates into the community once their period of imprisonment has ended.
Right or left-handed: are locomotion type, body size, and microhabitat related to forelimb laterality in anurans?
Authors: Rojas-Montoya Maribel , Vargas-Salinas Fernando 
Published: November 2023

AbstractLaterality, the tendency of animals to use the structures on one side of the body more frequently or efficiently than the other side, can reflect the evolutionary history of species, their ecological characteristics, and cognitive abilities. Using anurans as a model system, it has been hypothesized that the strength of laterality (measured as the percentage of right-handed individuals) is higher in terrestrial and arboreal species, which exhibit asynchronous locomotion type (e.g., walking, climbing), than in aquatic species where synchronous locomotion type (e.g., swimming) predominates. We tested these predictions, including body size as an additional factor, in 19 Neotropical anuran species. For this, we obtained data on forelimb use preference for individuals of such species. We then combined these data with published data for another 14 anuran species obtained through a systematic review of the literature. The combined dataset was used to perform a phylogenetic comparative analysis to verify the strength of laterality in the species. We found that four out of the 19 tested species show a percentage of right-handed individuals that was higher or lower than expected by chance. Individuals of these four species exhibit asynchronous movements of forelimbs during displacements, foraging behaviors, sexual displays, or agonistic interactions. Results of a phyloANOVA and a phyloANCOVA indicated that the strength of laterality was higher in species with asynchronous movements, but this was unrelated to microhabitat and body size. Asynchronous (i.e., non-simultaneous) movements of limbs imply alternating muscle contractions and a higher neural asymmetry than synchronous (i.e., simultaneous) movements of limbs. Therefore, species with an asynchronous locomotion type could be reflecting such complexity and neural asymmetry in higher levels of forelimb laterality. Our results mostly support the predictions based on models that cover the expected relationship between the strength of laterality and the evolutionary ecology of vertebrates.
Empathy, Motivating Reasons, and Morally Worthy Action
Authors: Ventham Elizabeth 
Published: November 2023

AbstractContemporary literature criticises a necessary link between empathy and actions that demonstrate genuine moral worth. If there is such a necessary link, many argue, it must come in the developmental stages of our moral capacities, rather than being found in the mental states that make up our motivating reasons. This paper goes against that trend, arguing that critics have not considered how wide-ranging the mental states are that make up a person’s reasons. In particular, it argues that empathy can play a role in moral motivation when it is to some extent unconscious or it occurs far prior to the moral action itself.
Does religion matter to angels? Exploring the influence of religion in entrepreneurial investor decision-making
Authors: Jones Jessica , Hymer Christina , Roccapriore Ashley , Smith Brett 
Published: November 2023

AbstractDespite the pervasive influence religion has on society, the role of religion in angel investor decision-making remains unknown. This study tests a model of how religion – both as a guiding institutional logic and a personal religious belief – influences angel investor evaluations. Drawing on the similarity attraction paradigm and expectancy violation theory, two scenario-based experiments find religion has a persistent but nuanced influence on investor evaluations. Generally, religious claims are a double-edged sword, either repelling or attracting angel investors. Specifically, faith-driven investors form positive evaluations of the venture but only when these evaluations are mediated by entrepreneur authenticity. By comparison, traditional angel investors form negative evaluations when religious claims are present, except for when angel investor religiosity is high. This suggests that faith-driven and traditional angel investors use different bases for evaluating entrepreneurs and ventures. Overall, our results have important implications for understanding the theological turn to entrepreneurship by finding religion as a double-edge sword, a multilevel influence, and a cognitive mechanism within investor decision-making.
Truth as none and many
Authors: Gamester Will 
Published: November 2023

AbstractTruth pluralists say that there are many ways to be true. Aaron Cotnoir (“Pluralism and Paradox” in: Pedersen and Wright (eds) Truth and pluralism: current debates, Oxford University Press, Oxford, 2013) has suggested a “uniquely pluralist response to the liar”. The basic idea is to maintain that, if a sentence says of itself that it is not true in a certain way, then that sentence is not apt to be true in that way, but is instead apt to be true in a different way. While this is consistent with the basic tenets of truth pluralism, it is an open question whether or not it is amenable to any actual pluralist theory. The primary goal of this paper is to argue that Cotnoir's proposal is amenable to form-based pluralism, rather than domain-based pluralism. In particular, in Section 1, I argue that there are several serious obstacles in the way of the domain-based pluralist who wishes to endorse Cotnoir's proposal; in Section 2, I show how the form-based pluralist can overcome these difficulties. The secondary goal of the paper is to argue that most, if not all, substantivists about truth should find form-based pluralism independently attractive. As such, the possibility of a form-based pluralist solution to the liar is not merely a technical curiosity, but something in which substantivists about truth have a vested interest.
Existence of solutions for the problem of microwave heating and a Liapunoff criteria for stability and instability
Authors: Cimatti Giovanni 
Published: November 2023

AbstractThe Galerkin’s method is applied to prove the existence of at least one solution of the initial boundary value problem for the nonlinear system of partial differential equations modelling the electromagnetic heating of materials. In addition a criteria of stability and instability based on a Liapunoff function is presented.
Linking top managers’ behavioural traits with business practices and firm performance
Authors: Kim Huong Trang , Nguyen Quang 
Published: November 2023

AbstractWe embed an experiment in an ongoing firm-level panel survey with a sample of 623 firms managed by their owners to explore the role of top managers’ behavioral traits as drivers of corporate strategies and performance. We find that present biased managers are less likely to invest in business practices, leading to lower sales revenue. Younger managers are more patient and less risk-averse than older ones, and they play a more significant role in improving firm performance than their counterparts. Interestingly, we find compelling evidence that business practices play a crucial role as a mediating mechanism through which managers’ present bias and loss aversion affect firm performance.
A-site cation engineering of cesium and MAPb0.5Sn0.5I3 perovskite: the properties and optoelectronic performance analysis using DFT calculations
Authors: Mbumba Manala Tabu , Mahona John , Kihedu Joseph , Chang’waro Salum K. , John Geoffrey R. 
Published: November 2023

AbstractHere, the first-principle calculations with the density functional theory calculations with PBE exchange–correlation functional were employed in investigating the effect of Cesium in the properties and optoelectronic performance of MAPb0.5Sn0.5I3 perovskite using A-site cation engineering technique. The control and Cesium based perovskites were generated and computed through CASTEP analysis from Material studio to determine their properties as well as optoelectronic performance. The findings revealed an improved properties of Cesium added perovskite compared to control ones. However, above 15%Cesium, phase separation was seen which declined the quality of the perovskite films. Moreover, simulation results of perovskites added with Cesium to 15% have demonstrated to have an improved optoelectronic performance as well as thermal stability by maintaining about 76% compared to the control which can retain about 39% of their initial power conversion efficiency after 15 days of aging at 85 °C in the ambient condition. This research presents a viable approach to investigate the impact of cation composition tuning on band gap, which can be extended to other perovskites. Additionally, it offers a broad set of design guidelines prior experiments for attaining a targeted band gap and modifying perovskite crystallization to enhance the characteristics, thermal stability, and optoelectronic performance of perovskite solar cells.
The UNGPs and ISDS: Should Businesses Assess the Human Rights Impacts of Investor–State Arbitration?
Authors: Triefus Stephanie 
Published: November 2023

Abstract
Investor–state dispute settlement (ISDS) has been heavily criticized from the perspective of human rights. However, the potential adverse human rights impacts of ISDS and the responsibilities of businesses to avoid causing or contributing to those impacts under the UN Guiding Principles on Business and Human Rights have yet to be spelled out. Although states are currently reforming ISDS, progress has been slow, and businesses have an independent responsibility to ensure that their operations do not harm human rights. Against this background, this article unpacks how businesses might contribute to three non-exhaustive examples of potential human rights impacts of ISDS: namely, the chilling effect on human rights regulation, crippling mega-awards and direct impacts on third-party rights. This article breaks new ground by exploring how human rights due diligence could be a useful tool for businesses to identify and address these impacts.
Honorific mismatches of coordinate subjects in Korean
Authors: Kim Jeong-Seok , Jung Duk-Ho , Lee Jin Hyung 
Published: November 2023

AbstractIn this article, we explore whether hierarchy and linearity conspire to affect agreement. The data come from an experimental study of honorific agreement between verbal si and coordinate subjects in Korean. We focus on computing the mismatch driven by honorifically mixed conjuncts. Unlike South Slavic gender agreement, Korean has neither Resolved Agreement nor First Conjunct Agreement. Only Last Conjunct Agreement is attested in Korean honorification. We show that honorific agreement within coordinate subjects is triggered only when the honorific verbal si appears, which is substantially different from the case with the honorific nominal nim. We also show that acceptability significantly decreases when the last conjunct of coordinate subjects is incongruous with an honorific verb. We thus argue that verbal honorific agreement with Korean coordinate subjects is sensitive to linear order, mimicking South Slavic gender agreement.
Echo Chambers and Friendship
Authors: Güngör Alper 
Published: November 2023

Abstract
Are the members of echo chambers blameworthy for their beliefs? If we follow Sarah Stroud's account of friendship, we end up with the following conclusion: if echo chambers involve friendship, then the individuals have strong reasons not to live up to epistemic demands or ideals when the friendships are formed in the echo chambers they are members of. This result stands in striking contrast with the received view, according to which the members of echo chambers are blameworthy for their epistemic vices and faulty beliefs. The received view uses individual epistemic vices to propose individualistic solutions for the problem of echo chambers. I argue that this is misleading, simply because the members of echo chambers are not blameworthy due to the friendships cultivated in the echo chambers.