bluuebunny/crossref_metadata_2025_split huggingface dataset:
Psychosocial factors and interleukin‐6 among women with advanced ovarian cancer
Authors: Costanzo Erin S. , Lutgendorf Susan K. , Sood Anil K. , Anderson Barrie , Sorosky Joel , Lubaroff David M. 
Published: June 2005

AbstractBACKGROUNDRelations among psychological stress, depression, social support, and interleukin‐6 (IL‐6, a proinflammatory cytokine) have been documented in humans and animals. Because elevated IL‐6 is associated with a poorer prognosis among ovarian cancer patients and has been implicated in the metastasis of ovarian cancer, the current study examined relations between psychosocial factors and IL‐6 among women with advanced‐stage ovarian cancer.METHODSSixty‐one ovarian cancer patients completed assessments of social support, distressed mood, and quality of life before surgery. Peripheral blood was drawn preoperatively, and the plasma was assayed for IL‐6. Ascites samples were also assayed for IL‐6 for a subset of patients.RESULTSBoth IL‐6 levels and distressed mood were elevated among patients. After statistically adjusting effects of age and disease stage, social attachment was associated with lower levels of IL‐6 in peripheral blood (P= 0.03), whereas poorer health‐related quality of life was associated with higher IL‐6 (Pvalues ranged from 0.01 to 0.03 on different measures). This pattern of relations was also found in the ascites. Moreover, IL‐6 levels in peripheral blood plasma correlated significantly with IL‐6 in the ascites (P< 0.001), suggesting that peripheral IL‐6 reflects IL‐6 levels at the site of the tumor.CONCLUSIONSResults suggest that social support may play a protective role with respect to IL‐6 elevations, and IL‐6 may be an independent marker of health‐related quality of life among ovarian cancer patients. Processes involving IL‐6 represent possible pathways by which behavioral factors may contribute to disease outcomes among women with ovarian cancer. Cancer 2005. © 2005 American Cancer Society.
Fused Tetracyclic Heterocycles by Thermally Initiated Intramolecular Criss‐Cross Cycloaddition of 3‐Substituted Homoallenylaldazines
Authors: Zachová Hana , Man Stanislav , Nečas Marek , Potáček Milan 
Published: June 2005

AbstractThe thermally initiated intramolecular criss‐cross cycloaddition of 3‐substituted homoallenylaldazines 5 has been explored. Their cyclization led to interesting new fused heterocyclic systems 6 consisting of four five‐membered rings with two nitrogen heteroatoms. The azines were prepared by the reaction of homoallenyl aldehydes 4 with hydrazine. The homoallenyl aldehydes 4 were synthesized by the Claisen rearrangement of new N,N‐disubstituted 4‐[(2‐methylprop‐1‐en‐1‐yl)oxy]but‐2‐yn‐1‐amines 3a–f prepared by Mannich reaction of 2‐methylprop‐1‐en‐1‐yl prop‐2‐yn‐1‐yl ether (2). The success of the reaction was based on the improved solvent‐free synthesis of 1‐chloro‐2‐methylpropyl prop‐2‐yn‐1‐yl ether (1) and its conversion to isolable 2‐methylprop‐1‐en‐1‐yl prop‐2‐yn‐1‐yl ether (2) in high yield. (© Wiley‐VCH Verlag GmbH & Co. KGaA, 69451 Weinheim, Germany, 2005)
A Highly Selective Fluorescent Chemosensor for H2PO4– Based on a Calix[4]arene Tetraamide Derivative
Authors: Chen Qi‐Yin , Chen Chuan‐Feng 
Published: June 2005

AbstractA new neutral fluorescent chemosensor 5 based on a calix[4]arene tetraamide derivative has been synthesized. It exhibits high selectivity for H2PO4– over a wide range of anions, and the selectivity for H2PO4– is more than 2700‐fold higher than for F–. In acetonitrile, the fluorescence intensity of 5 is efficiently enhanced about 130 % [(I – I0)/I0] upon the addition of 5 equiv. of H2PO4–. From the fluorescence titration experiments, the association constant for 5/H2PO4– (1:2) was calculated to be 5.48 × 109 M–2. Furthermore, the 1H NMR spectral and X‐ray crystal studies suggested that multiple hydrogen‐bonding interactions occur between 5 and H2PO4–.
A Total Synthesis of (+)‐ and (–)‐Dihydrokavain with a Sonochemical Blaise Reaction as the Key Step
Authors: Wang Fang‐Dao , Yue Jian‐Min 
Published: June 2005

AbstractStarting from 2,3‐O‐isopropylidene‐D‐glyceraldehyde (2) as chiral material, the naturally occurring (S)‐(+)‐dihydrokavain (1a) was synthesized by a procedure that involves a sonochemical Blaise reaction as the key step. The absolute configuration of (S)‐(+)‐dihydrokavain (1a) is demonstrated for the first time by total synthesis from a chiral source. Its opposite enantiomer, (R)‐(–)‐dihydrokavain (1b), was also synthesized after inversion of the chiral center in a Mitsunobu reaction. (© Wiley‐VCH Verlag GmbH & Co. KGaA, 69451 Weinheim, Germany, 2005)
Sequential Diastereoselective Addition of Allylic and Homoallylic Grignard Reagents to 2‐Acyl‐perhydro‐1,3‐benzoxazines and Ring‐Closing Metathesis: an Asymmetric Route to Azepin‐3‐ol and Azocin‐3‐ol Derivatives
Authors: Pedrosa Rafael , Andrés Celia , Gutiérrez‐Loriente Agustín , Nieto Javier 
Published: June 2005

AbstractChiral 2‐acyl‐3‐allyl‐substituted perhydrobenzoxazines derived from (–)‐8‐aminomenthol react with allyl or homoallyl Grignard reagents to provide the corresponding tertiary alcohols in very good yields and with excellent diastereoselectivities. The 1,8‐ and 1,9‐azadienes prepared in this way participate in RCM reactions to give good yields of seven‐ and eight‐membered nitrogen heterocycles. The yields of the RCM reaction increased when the hydrochlorides were used instead of the neutral azadienes. The removal of the chiral adjuvant allowed the preparation of enantiopure azepin‐3‐ol and azocin‐3‐ol derivatives. (© Wiley‐VCH Verlag GmbH & Co. KGaA, 69451 Weinheim, Germany, 2005)
Steric Effects in Isolated Molecules: Gas‐Phase Basicity of Methyl‐Substituted Acetophenones
Authors: Böhm Stanislav , Gal Jean‐François , Maria Pierre‐Charles , Kulhánek Jiří , Exner Otto 
Published: June 2005

AbstractThe energies of 14 methyl‐substituted acetophenones and of their protonated forms were calculated within the framework of the density functional theory at the B3LYP/6‐311+G(d,p) level. The gas‐phase basicities of some members of this series were measured using Fourier transform ion cyclotron resonance mass spectrometry in order to complete the known data. The protonated forms exist in two configurations differing in the position of the hydrogen atom; their equilibrium depends strongly on the substitution pattern. Taking into account all conformational equilibria, the experimental and calculated basicities agreed to within 2.7 kJ mol–1. Substituent effects were tentatively resolved into polar and steric contributions by comparing the corresponding ortho and para derivatives. The steric effect of the ortho‐methyl groups defined in this way has a clear physical meaning proven by several correlations; it destabilizes the neutral acetophenone molecules but destabilizes the cations even more. Hence it is base‐weakening relative to the steric effect on the acidity of substituted benzoic acids, which is acid‐strengthening. (© Wiley‐VCH Verlag GmbH & Co. KGaA, 69451 Weinheim, Germany, 2005)
Hybrid Bioorganic–Inorganic Materials Prepared by Site‐Specific Ligation of Peptides to Functionalized Polydisperse Silica Particles
Authors: Joly Pascal , Ardès‐Guisot Nicolas , Kar Samiran , Granier Michel , Durand Jean‐Olivier , Melnyk Oleg 
Published: June 2005

AbstractWe describe the synthesis of semicarbazide‐ or glyoxylyl‐functionalized polydisperse silica particles and their use for the preparation of hybrid polypeptide–silica materials. The peptides were attached to the surface of functionalized silicas by site‐specific α‐oxo hydrazone or semicarbazone ligation. The reaction of semicarbazide silicas with a model glyoxylyl peptide was found to be very efficient under stoichiometric conditions and led to ligation yields of about 90 %. The use of glyoxylyl silicas and of hydrazinoacetyl peptides led to lower yields. (© Wiley‐VCH Verlag GmbH & Co. KGaA, 69451 Weinheim, Germany, 2005)
Strategies for the Total Asymmetric Synthesis of Heliannuols K and L: Scope and Limitations
Authors: Lecornué Frédéric , Paugam Renée , Ollivier Jean 
Published: June 2005

AbstractKulinkovich reactions of oxa‐esters bearing terminal double bonds afford cyclopropanols by intramolecular cyclization. These can undergo Saegusa oxidation to provide β‐chloro‐oxacycloalkanones and can then be then dehydrohalogenated into oxacycloalkenones. Through a judicious choice of starting esters, diverse aryl‐fused benzoxocinones possessing the basic skeleton of sesquiterpenes, such as heliannuols, can be obtained. Although the syntheses of certain compounds in racemic form seem accessible, however, improvements through new strategies are still required for the total asymmetric synthesis. This article describes the first synthesis of enantiomerically enriched OMe‐heliannuol K and the first stereo‐ and enantioselective synthesis of heliannuol L, and new approaches and studies of their limitations in the preparation of these products are detailed. (© Wiley‐VCH Verlag GmbH & Co. KGaA, 69451 Weinheim, Germany, 2005)
Influence of the Conformation of Salen Complexes on the Stereochemistry of the Asymmetric Epoxidation of Olefins
Authors: Scheurer Andreas , Maid Harald , Hampel Frank , Saalfrank Rolf W. , Toupet Loic , Mosset Paul , Puchta Ralph , van Eikema Hommes Nico J. R. 
Published: June 2005

AbstractCompared with Katsuki’s or Jacobsen’s catalysts (R,R,R,R)‐1 or (R,R)‐2, the phenomenon of reversed asymmetric induction in the course of the epoxidation of unfunctionalised olefins in the presence of (salen)manganese complex (S,S)‐3 is indirectly explained by means of quantumchemical calculations, as well as by 1H NMR spectra of salen ligand (S,S)‐10 and diamagnetic low‐spin nickel complex (S,S)‐7 and by its X‐ray structure analysis. Whereas in (R,R,R,R)‐1 and (R,R)‐2 the phenyl and cyclohexyl substituents occupy equatorial positions, the origin for the reversed enantioselection caused by manganese catalyst (S,S)‐3, is based on an axial position of the acyclic heteroalkyl substituents in the diimine backbone of (S,S)‐3 as exemplarily confirmed by model nickel complex (S,S)‐7. (© Wiley‐VCH Verlag GmbH & Co. KGaA, 69451 Weinheim, Germany, 2005)
Tricarbonyl(naphthoquinone)chromium: Synthesis and Application in [4+2] Cycloaddition Reactions
Authors: Möhring Daniel , Nieger Martin , Lewall Burhanshah , Dötz Karl Heinz 
Published: June 2005

AbstractTricarbonyl(naphthoquinone)chromium (9) has been prepared in an 82 % overall yield by direct complexation of TBS‐protected naphthohydroquinone (6) and subsequent deprotection/oxidation. Complex 9 underwent [4+2] cycloaddition reactions with a series of dienes to give products in good to excellent yields. The cycloaddition reaction revealed that the tricarbonylchromium fragment exhibits perfect endo selectivity and has an anti‐directing role, as established by X‐ray analyses of the Diels–Alder products 10–13. (© Wiley‐VCH Verlag GmbH & Co. KGaA, 69451 Weinheim, Germany, 2005)
Allylation of Aldehyde and Imine Substrates with In Situ Generated Allylboronates – A Simple Route to Enatioenriched Homoallyl Alcohols
Authors: Sebelius Sara , Szabó Kálmán J. 
Published: June 2005

AbstractAllylation of aldehyde and imine substrates was achieved using easily available allylacetates and diboronate reagents in the presence of catalytic amounts of palladium. This operationally simple one‐pot reaction has a broad synthetic scope, as many functionalities including, acetate, carbethoxy, amido and nitro groups are tolerated. The allylation reactions proceed with excellent regio‐ and stereoselectivity affording the branched allylic isomer. By employment of commercially available chiral diboronates enantioenriched homoallyl alcohols (up to 53 % ee) could be obtained. The mechanistic studies revealed that the in situ generated allylboronates react directly with the aldehyde substrates, however the allylation of the sulfonylimine substrate requires palladium catalysis. (© Wiley‐VCH Verlag GmbH & Co. KGaA, 69451 Weinheim, Germany, 2005)
Enhanced extrastriate visual response to bandpass spatial frequency filtered fearful faces: Time course and topographic evoked‐potentials mapping
Authors: Pourtois Gilles , Dan Elise S. , Grandjean Didier , Sander David , Vuilleumier Patrik 
Published: June 2005

AbstractWe compared electrical brain responses to fearful vs. neutral facial expressions in healthy volunteers while they performed an orthogonal gender decision task. Face stimuli either had a broadband spatial‐frequency content, or were filtered to create either low spatial‐frequency (LSF) or high spatial‐frequency (HSF) faces, always overlapped with their complementary SF content in upside‐down orientation to preserve the total stimulus energy. We tested the hypothesis that the coarse LSF content of faces might be responsible for an early modulation of event‐related potentials (ERPs) to fearful expressions. Consistent with previous findings, we show that broadband images of fearful faces, relative to neutral faces, elicit a higher global field power of approximately 130 ms poststimulus onset, corresponding to an increased P1 component over lateral occipital electrodes, with neural sources located within the extrastriate visual cortex. Bandpass filtering of faces strongly affected the latency and amplitude of ERPs, with a suppression of the normal N170 response for both LSF and HSF faces, irrespective of expression. Critically, we found that LSF information from fearful faces, unlike HSF information, produced a right‐lateralized enhancement of the lateral occipital P1, without any change in the scalp topography, relative to unfiltered (broadband) fearful faces. These results demonstrate that an early P1 response to fear expression depends on a visual pathway preferentially tuned to coarse‐magnocellular inputs, and can persist unchanged even when the N170 generators are disrupted by SF filtering. Hum Brain Mapp, 2005. © 2005 Wiley‐Liss, Inc.
Visual evoked potentials recovered from fMRI scan periods
Authors: Becker Robert , Ritter Petra , Moosmann Matthias , Villringer Arno 
Published: June 2005

AbstractSimultaneous electroencephalography (EEG) and functional magnetic resonance imaging (fMRI) may allow functional imaging of the brain at high temporal and spatial resolution. Artifacts generated in the EEG signal during MR acquisition, however, continue to pose a major challenge. Due to these artifacts, an interleaved modus has often been used for “evoked potential” experiments, i.e., only EEG signals recorded between MRI scan periods were assessed. An obvious disadvantage of this approach is the loss of a portion of the EEG information, which might be relevant for the specific scientific issue. In this study, continuous, simultaneous EEG‐fMRI measurements were carried out. Visual evoked potentials (VEPs) could be reconstructed reliably from periods during MR scanning and in between successive scans. No significant differences between both VEPs were detected. This indicates sufficient artifact removal as well as physiological correspondence of VEPs in both periods. Simultaneous continuous VEP‐fMRI recordings are thus shown to be feasible. Hum Brain Mapp, 2005. © 2005 Wiley‐Liss, Inc.
Altered resting state networks in mild cognitive impairment and mild Alzheimer's disease: An fMRI study
Authors: Rombouts Serge A.R.B. , Barkhof Frederik , Goekoop Rutger , Stam Cornelis J. , Scheltens Philip 
Published: June 2005

AbstractActivity and reactivity of the default mode network in the brain was studied using functional magnetic resonance imaging (fMRI) in 28 nondemented individuals with mild cognitive impairment (MCI), 18 patients with mild Alzheimer's disease (AD), and 41 healthy elderly controls (HC). The default mode network was interrogated by means of decreases in brain activity, termed deactivations, during a visual encoding task and during a nonspatial working memory task. Deactivation was found in the default mode network involving the anterior frontal, precuneus, and posterior cingulate cortex. MCI patients showed less deactivation than HC, but more than AD. The most pronounced differences between MCI, HC, and AD occurred in the very early phase of deactivation, reflecting the reactivity and adaptation of the network. The default mode network response in the anterior frontal cortex significantly distinguished MCI from both HC (in the medial frontal) and AD (in the anterior cingulate cortex). The response in the precuneus could only distinguish between patients and HC, not between MCI and AD. These findings may be consistent with the notion that MCI is a transitional state between healthy aging and dementia and with the proposed early changes in MCI in the posterior cingulate cortex and precuneus. These findings suggest that altered activity in the default mode network may act as an early marker for AD pathology. Hum Brain Mapp, 2005. © 2005 Wiley‐Liss, Inc.
Characterization of Small Nodules in Cirrhosis by Assessment of Vascularity: The Problem of Hypovascular Hepatocellular Carcinoma *
Authors: Bolondi Luigi , Gaiani Stefano , Celli Natascia , Golfieri Rita , Grigioni Walter Francesco , Leoni Simona , Venturi Anna Maria , Piscaglia Fabio 
Published: June 2005

Abstract

In a prospective study, we examined the impact of arterial hypervascularity, as established by the European Association for the Study of the Liver (EASL) recommendations, as a criterion for characterizing small (1-3 cm) nodules in cirrhosis. A total of 72 nodules (1-2 cm, n = 41; 2.1-3 cm, n = 31) detected by ultrasonography in 59 patients with cirrhosis were included in the study. When coincidental arterial hypervascularity was detected at contrast perfusional ultrasonography and helical computed tomography, the lesion was considered to be hepatocellular carcinoma (HCC) according to EASL criteria. When one or both techniques showed negative results, ultrasound-guided biopsy was performed. In cases with negative results for malignancy or high-grade dysplasia, biopsy was repeated when an increase in size was detected at the 3-month follow-up examination. Coincidental hypervascularity was found in 44 of 72 nodules (61%; 44% of 1-2-cm nodules and 84% of 2-3-cm nodules). Fourteen nodules (19.4%) had negative results with both techniques (hypovascular nodules). Biopsy showed HCC in 5 hypovascular nodules and in 11 of 14 nodules with hypervascularity using only one technique. All nodules larger than 2 cm finally resulted to be HCC. Not satisfying the EASL imaging criteria for diagnosis were 38% of HCCs 1 to 2 cm (17% hypovascular) and 16% of those 2 to 3 cm (none hypovascular).
In conclusion
, the noninvasive EASL criteria for diagnosis of HCC are satisfied in only 61% of small nodules in cirrhosis; thus, biopsy frequently is required in this setting. Relying on imaging techniques in nodules of 1 to 2 cm would miss the diagnosis of HCC in up to 38% of cases. Any nodule larger than 2 cm should be regarded as highly suspicious for HCC. (Hepatology 2005.)
Autoimmune Hepatitis: Effect of Symptoms and Cirrhosis on Natural History and Outcome *
Authors: Feld Jordan J. , Dinh Huong , Arenovich Tamara , Marcus Victoria A. , Wanless Ian R. , Heathcote Jenny E. 
Published: June 2005

Abstract

Although the natural history of autoimmune hepatitis (AIH) has been characterized, little is known about patients who present asymptomatically. Consequently, whether they require immunosuppressive therapy with its associated complications is unclear. To compare the natural history of asymptomatic AIH with symptomatic AIH, a large cohort of patients from a single center was examined. All patients with a clinical diagnosis of AIH were reassessed using the revised criteria of the International Autoimmune Hepatitis Group. Liver histology, response to therapy, and survival were assessed. Patients asymptomatic at presentation (n = 31) had lower serum aminotransferase, bilirubin, and immunoglobulin G (IgG) values at baseline. Half of the asymptomatic patients received no therapy, and their survival was no different from that of the total cohort. Ten-year survival was 80.0% (62.5%-97.5%) in the asymptomatic group and 83.8% (75.1%-92.6%) in the symptomatic patients (

P

= NS). Survival to liver-related endpoints at 10 years was similar in both groups: 89.5% (75.7%-100%) asymptomatic and 83.8% (75.1%-92.6%) symptomatic patients (

P

= NS). Patients with cirrhosis at baseline had poorer 10-year survival (61.9% [CI 44.9%-78.9%]) than those without cirrhosis at presentation (94.0% [CI 87.4%-100%]) (

P

= .003) regardless of whether they presented with symptoms or whether they received immunosuppressive therapy.
In conclusion
, patients with AIH who are asymptomatic at presentation have a good prognosis and may not require immunosuppressive therapy. Cirrhosis on initial liver biopsy portends a poor prognosis in all patients with AIH. (Hepatology 2005.)
Properties of acrylic bone cements formulated with Bis‐GMA
Authors: Vallo Claudia I. , Schroeder Walter F. 
Published: June 2005

AbstractExperimental cement formulations were prepared by replacing part of the methylmethacrylate (MMA) liquid phase of a conventional surgical cement with an equivalent weight of 2,2‐bis [4(2‐hydroxy‐3‐methacryloxypropoxy) phenyl] propane (Bis‐GMA), which is the reaction product of diglycidyl ether of bisphenol A and methacrylic acid. It was found that up to 50 wt % of the MMA could be replaced by Bis‐GMA without reductions in flow characteristics of the precured polymers. Cements containing 20, 30, 40, and 50 wt % of Bis‐GMA in the liquid component were prepared. Over this range of Bis‐GMA wt %, it was found that, relative to the unmodified cement, the volumetric shrinkage (DV), the peak temperature reached during the polymerization reaction (Tp), and the flexural strength (obtained in three‐point bend tests) were each significantly reduced, the flexural modulus (obtained in three‐point bend tests) increased significantly, the compressive strength increased slightly, while there were no significant effects on any of the other properties determined, namely, degree of conversion of the monomer during the polymerization reaction and the glass transition temperature. The drops in DV and Tp indicate that cements whose liquid monomers are modified using Bis‐GMA hold promise for use in anchoring total joint replacements. The increase in the crosslinking density with increasing amount of Bis‐GMA renders the polymer matrix more brittle. This feature was considered responsible for the reduced flexural strength. © 2005 Wiley Periodicals, Inc. J Biomed Mater Res Part B: Appl Biomater, 2005
Pigmented retinal epithelium involvement in photoreceptor development and function
Authors: Hollyfield Joe G. , Witkovsky Paul 
Published: June 2005

AbstractThe importance of the pigmented retinal epithelium (PRE) for photoreceptor maturation during retinal development was evaluated in Rana pipiens. Retinal rudiments with or without an enveloping PRE were isolated from stage 18 embryos and allowed to develop in a non‐nutrient culture medium for up to 19 days. A set of morphological features with which to evaluate the degree of differentiation occurring in cultured material was obtained through examination of eyes of normal embryos, stages 18–25.Some photoreceptor outer segment material first appeared after 7 days in culture. The number of well‐ordered outer segment discs per receptor increased progressively with age in PRE‐covered retinas. However, photoreceptors of retinas lacking PRE contained little disc membrane material and this quickly lost proper orientation. Electroretinograms could first be elicited from PRE‐containing cultures after 7 days, but none were produced by retinas lacking a PRE. In PRE‐covered retinas a progressive differentiation of photoreceptor synaptic complexes was seen between 7–19 days; in retinas lacking a PRE, synaptic ribbons appeared after 7 days in culture, but no further maturation of the synapse was observed.The PRE itself underwent sequential differentiation and achieved the tadpole appearance after 17 days in culture. Both PRE and retina developed at the same rate in cultured material, and this rate was about one‐third that observed in eyes of embryos raised at the same temperature. These findings indicate that the PRE plays a critical role in photoreceptor development.