bluuebunny/crossref_metadata_2025_split huggingface dataset:
Reviewing the “Bilbao effect” inside and beyond the Guggenheim: Its coming of age in sprawling cultural landscapes
Authors: Lorente J. Pedro 
Published: October 2023

AbstractInvented by journalists, the “Bilbao effect” label has no clear meaning, but it undoubtedly refers to outwardly radiating waves of influence beyond the Guggenheim Museum Bilbao. Its architecture and urban impact, with trickle down economic returns, has drawn international attention and many emulators. Its museological novelties have inspired great changes in Spanish museums and in Basque cultural policies. However, the external effect of this institution beyond its headquarters should be tracked most particularly along the Abandoibarra district, which is now a thriving curatorial landscape, typifying an outdoors version of Svetlana Alpers's “museum effect.” Are we experiencing a paradigm shift? Outliving all sort of setbacks, the epitome of postmodern museums remains faithful to itself and new kinds of cultural clusters are being promoted beyond it. The current climate crisis has called into question previous assumptions of success based on massive international tourism, which is perhaps unsustainable. But the cultural district of Bilbao is booming and expanding down the Nervión river.
Structural‐functional properties of direct‐pathway striatal neurons at early and chronic stages of dopamine denervation
Authors: Li Chang , Elabi Osama F. , Fieblinger Tim , Cenci M. Angela 
Published: October 2023

AbstractThe dendritic arbour of striatal projection neurons (SPNs) is the primary anatomical site where dopamine and glutamate inputs to the basal ganglia functionally interact to control movement. These dendritic arbourisations undergo atrophic changes in Parkinson's disease. A reduction in the dendritic complexity of SPNs is found also in animal models with severe striatal dopamine denervation. Using 6‐hydroxydopamine (6‐OHDA) lesions of the medial forebrain bundle as a model, we set out to compare morphological and electrophysiological properties of SPNs at an early versus a chronic stage of dopaminergic degeneration. Ex vivo recordings were performed in transgenic mice where SPNs forming the direct pathway (dSPNs) express a fluorescent reporter protein. At both the time points studied (5 and 28 days following 6‐OHDA lesion), there was a complete loss of dopaminergic fibres through the dorsolateral striatum. A reduction in dSPN dendritic complexity and spine density was manifest at 28, but not 5 days post‐lesion. At the late time point, dSPN also exhibited a marked increase in intrinsic excitability (reduced rheobase current, increased input resistance, more evoked action potentials in response to depolarising currents), which was not present at 5 days. The increase in neuronal excitability was accompanied by a marked reduction in inward‐rectifying potassium (Kir) currents (which dampen the SPN response to depolarising stimuli). Our results show that dSPNs undergo delayed coordinate changes in dendritic morphology, intrinsic excitability and Kir conductance following dopamine denervation. These changes are predicted to interfere with the dSPN capacity to produce a normal movement‐related output.
Neurological complications during the Omicron COVID‐19 wave in China: A cohort study
Authors: Lu Lu , Chen Lei , Wang Peiyu , Qi Zhang , Chen Yujie , Wu Xintong , Liu Xu , Wang Minjin , Li Jinmei , Yan Bo , Guo Jian , Teng Sisi , Li Weimin , Sander Josemir W. , Zhou Dong , Xiong Weixi 
Published: October 2023

AbstractBackground and purposeThe aim was to investigate the neurological complications associated with coronavirus disease 19 (COVID‐19) during the 2022 Omicron wave.Methods and analysisThe medical records of a cohort of people admitted to neurological wards of three participating tertiary centres in Sichuan from 12 December 2022 to 12 January 2023 were reviewed. Demographics and clinical data were obtained and analysed with an interest in COVID‐19‐related new‐onset or worse neurological symptoms. The current data were also compared in two centres with similar data from the same period 12 months earlier.ResultsIn all, 790 people were enrolled, of whom 436 were positive for COVID‐19. Ninety‐nine had new onset COVID‐related neurological problems, or their known neurological condition deteriorated during the wave. There was a significant difference in demographics from the findings amongst admissions 12 months earlier as there was an increase in the average age, the incidence of encephalitis and encephalopathy, and mortality rates. One hundred and one received COVID‐specific antivirals, intravenous glucocorticoids and intravenous immunoglobulin therapy. No differences were seen between these and those who did not use them.ConclusionNew‐onset neurological conditions, particularly encephalitis and encephalopathy, increased significantly during this period. Deterioration of existing neurological conditions, such as seizure exacerbation, was also observed. A large‐scale treatment trial of people with COVID‐19 infection presenting with neurological disorders is still needed.
Meta‐analytic assessment of physiological markers for decapod crustacean welfare
Authors: Conneely Ellie‐Ann , Coates Christopher J. 
Published: October 2023

AbstractDecapod crustacean welfare is not only an ethical consideration for legislative purposes. Under culture and fishery settings, poor environmental conditions and operator practices can cause stress, which compromises the immune system and increases the risk of disease. For finfish, there are established environmental and animal (group, individual) welfare indicators. This is not the case for crabs, lobsters or shrimp. While environment‐based indicators like temperature, pH and oxygen levels are easily transferable, there is no consensus for a common measure of stress to monitor welfare in decapod crustaceans. To address this shortcoming, we conducted a meta‐analysis of the primary literature to test for relationships between haemolymph (blood) condition, for example, levels of glucose, L‐lactate, haemocytes (n = 8), and sources of physical stress, for example, handling, trawling, emersion and transport (n = 12). Despite variations in effect sizes (n = 459), generalised linear mixed models repeatedly ranked L‐lactate (followed by urea and glucose) as the most significant physiological predictor of stress in the haemolymph, with trawling followed closely by emersion as the most impactful stressors. Duration post (stress) exposure, sex (male, female), water temperature and moult stage (pre‐, inter‐, post‐moult) were not associated significantly with stress prediction using the selected biochemical and cellular parameters, however, moult status was undefined in ~48% of literature sources and should be interpreted with caution. We present evidence that quantitating L‐lactate levels in the haemolymph represents a physiologic operational welfare indicator of decapod crustaceans, which complements existing condition/vigour indices.
Efficacy of panthenol‐ and bisabolol‐containing lip care as monotherapy for mild‐to‐moderate cheilitis
Authors: Varothai Supenya , Chaweekulrat Pichanee , Pruksaeakanan Chutipon , Wongdama Supisara , Boonchai Waranya 
Published: October 2023

AbstractBackgroundCheilitis is a chronic inflammatory condition of the lips, and frequent or prolonged use of topical corticosteroids may lead to various adverse events. Therefore, alternative therapies with fewer side effects are beneficial for the treatment of this condition.AimTo evaluate the efficacy of a lip care formulation containing both panthenol and bisabolol as a monotherapy for mild‐to‐moderate cheilitis.MethodsThis single‐centre prospective pilot open‐label study included 20 patients with mild‐to‐moderate cheilitis who were treated with the tested lip care for 8 weeks and evaluated by physician and patient assessments before the final efficacy was determined using the Visioscan score.ResultsOf the 20 patients, 13 (65.0%) presented with moderate cheilitis with dry and chapped lips. All parameters, including physician and patient clinical scores and bioengineering measurements, showed significant improvements as early as week 2 and sustained until week 8 following the application of the tested lip care. The frequency of cheilitis flareups also decreased significantly. The tested product was well tolerated without any adverse effects.ConclusionsLip care with panthenol and bisabolol was safe and effective. It can be used as monotherapy for the treatment of mild‐to‐moderate cheilitis.
Optimization of corrosion resistance and mechanical properties of Al2O3‐Cr2O3 refractories for waste incinerator
Authors: An Yi , Liu Hao , Wang Zhoufu , Ma Yan , Wang Xitang 
Published: October 2023

AbstractThe corrosion resistance and mechanical properties directly affects the operation and service life of Al2O3‐Cr2O3 refractories used in waste incinerators. In this study, ZrO2 particles were introduced via vacuum impregnation to adjust microstructure and properties of Al2O3‐Cr2O3 refractories. The results showed that the impregnated ZrO2 particles and increasing impregnation times resulted in the decreased median pore size and increased compactness, and mechanical strengths of refractories were elevated from the inhibited cracks propagation by ZrO2 particles. The decreased amounts of large pores and increased amounts of small pores from the filled ZrO2 particles inhibited penetration of low melting point phases, and the formed CaZrO3 phase from the reactions between corrosion reagent and ZrO2 particles increased the viscosity of penetrated corrosion reagent, resulting in the decreased penetration index from 8.57% to 2.58%. Meanwhile, the filled ZrO2 particles around alumina particles prevented reactions between molten corrosion reagent and alumina, leading to the decreased corrosion index from 3.78% to .74%. The decreased pore size and formation of CaZrO3 phase were primary factors that enhanced the penetration resistance. And formation of wrapped layers from ZrO2 particles around alumina particles presented prominent effects on the strengthened corrosion resistance of Al2O3‐Cr2O3 refractories.
Effects of SiC nanowires and whiskers on high‐entropy carbide‐based composites sintered at low and high temperatures
Authors: Liu Yang , Guo Wei‐Ming , Huang Kun‐Heng , Lin Hua‐Tay 
Published: October 2023

AbstractThis study aimed to investigate the toughening effects of SiC nanowires (SiCnw) and SiC whiskers (SiCw) on high‐entropy carbide based composites prepared at different temperatures (1600°C and 2000°C). At low temperature (1600°C), SiCnw and SiCw maintain their original morphology and properties, and exhibit the good toughening effects. The SiCnw with larger aspect ratio and more curly wires exhibit a much stronger toughening effect on the (Ti0.2Zr0.2Nb0.2Ta0.2Mo0.2)C0.8 composites reinforced with 15 vol.% SiCnw, which shows the highest value of fracture toughness about 6.7 MPa∙m1/2. However, at high sintering temperature (2000°C), SiCnw and SiCw are prone to thermal‐induced damages, which significantly reduces their mechanical properties, and thus, toughening effects on (Ti0.2Zr0.2Nb0.2Ta0.2Mo0.2)C0.8 composites. The addition of SiCw, which have better thermal stability at 2000°C, results in the (Ti0.2Zr0.2Nb0.2Ta0.2Mo0.2)C0.8–15 vol.% SiCw composite exhibiting relatively better fracture toughness, about 3.7 MPa∙m1/2. Based on the results of the current study, the critical influence of SiCnw and SiCw on the toughening of (Ti0.2Zr0.2Nb0.2Ta0.2Mo0.2)C0.8 composites is highly dependent on their high‐temperature thermal stability.
Impact of soybean protein isolate on gluten‐free bread: a comprehensive study of physicochemical properties of gluten‐free dough and bread matrix properties
Authors: Yang Yang , Zhang Can , Ma Chun‐Min , Hu Liang‐Shu , Bian Xin , Wang Bing , Zhang Na 
Published: October 2023

SummaryRice bread is an essential component of a healthy diet. However, due to the poor processing properties of rice protein and starch, it is difficult to form an effective gel network structure, resulting in poor quality of rice breads. This research investigated the impacts of soy protein isolate (SPI) on the physicochemical properties of rice dough and the quality of rice bread. The results suggested that adding SPI could refine the thermal stability of mixtures and delay the aging of starch compared with pure rice flour, indicating that adding SPI reduced the amylose concentration and inhibited starch interaction in the mixed rice powder system. The rheology and SEM analysis of doughs showed that the appropriate addition of SPI increased the elasticity, and reached the highest fermentation height and gas retention coefficient at 9% SPI content, which increased by 115.38% and 8.39%, respectively. In contrast, excessive SPI led to protein aggregation and weakened the structural strength of the dough. When adding 9% SPI improved the hardness, chewiness and specific volume of rice bread, significantly reduced the brightness and baking loss rate, and refined the performance and quality of rice bread. This study confirms that SPI can be used as an improver for good gluten‐free bread (GFB) through its good functional properties and action on starch and provides some basis for further investigation of the interaction between SPI as an improver and rice starch.
Basal Cell Carcinoma of the Vulva with Lymph Node and Skin Metastasis
Authors: Mizushima Junichi , Ohara Kuniaki 
Published: October 2023

AbstractA 79‐year‐old Japanese woman who had basal cell carcinoma presenting as a large ulcer on her vulva with lymph node and skin metastasis is described. Histological examination revealed that tumor nests with peripheral palisading invaded deeply into the subcutaneous tissue and were accompanied by marked mucinous changes and fibrous reaction. Vascular invasion was also observed. There were inguinal lymph node metastases and two papular skin metastases on her right thigh. The primary tumor and the metastases were excised. The defect was repaired by bilateral gracilis musculo cutaneous flaps and a skin graft.We surveyed the literature and found 20 cases of metastasizing basal cell carcinoma in Japan.
RETRACTED: Exploiting Cu+–Na+ ion‐exchanged and Ar/H2 annealed glass matrix to synthesize copper nanoparticles
Authors: Toumi Safa , Adawy Alaa , Quaranta Alberto , Farah Khaled 
Published: October 2023

AbstractCopper nanoparticles (CuNPs) were successfully prepared in Cu+–Na+ ion‐exchanged commercially available silicate glasses followed by being annealed in Ar/H2 atmosphere; in an approach that can be quite economic capable of modifying the physicochemical properties of glass. This approach resulted in the growth of spherical and crystalline CuNPs, with an average size of 67.5 nm, which is greater than the CuNPs average size obtained with annealing at air atmosphere (15.8 nm). On the treated glasses, phase transitions indicative of a shape memory effect and dendritic structures were also detected, indicating their vital roles, as crystal growth mechanisms in the resultant CuNPs. The surface plasmon peaks of CuNPs have been clearly observed in absorption spectra of doped annealed glasses at 350, 450, and 550°C in Ar/H2. Photoluminescence studies have proved the presence of both Cu+ and Cu2O. The detailed methodology and the structural and morphological characterizations of the annealed copper ion‐exchanged samples were carried out using optical microscopy (OM), X‐ray photoelectron spectroscopy (XPS), scanning electron microscopy (SEM), and transmission electron microscopy and high‐resolution TEM (TEM and HRTEM), and their reasoning are thoroughly described and discussed.
Redefining primary hyperaldosteronism as “The Syndrome of Inappropriate Aldosterone Secretion (SIALDS)”: A common but unrecognized cause of hypertension
Authors: Lamba Rajat 
Published: October 2023

AbstractThe current screening and diagnostic recommendations for detecting Primary Hyperaldosteronism (PHA) focus on diagnosing the more severe and overt instances of renin‐independent aldosterone production. However, milder forms of autonomous aldosterone secretion have been demonstrated to exist below the diagnostic thresholds of current PHA guidelines, and associate with clinically relevant cardiovascular risk. PHAencompasses a spectrum of renin independent aldosterone production, progressing from a subclinical state in normotensives to a full‐blown clinical syndrome representing the resistant hypertension population. The authors propose the Syndrome of Inappropriately Elevated Aldosterone Secretion (SIALDS) concept as a potential new paradigm for understanding and diagnosing PHA and expanded diagnostic approach to improve early detection even in well‐controlled hypertension. The authors also delve into the impact of treatments, including mineralocorticoid receptor antagonists and emerging aldosterone synthase inhibitors. Furthermore, The authors outline future research directions, proposing clinical trials to investigate the long‐term identification and treatment outcomes of SIALDS.
Consumers' macroeconomic expectations
Authors: Dräger Lena , Lamla Michael J. 
Published: October 2023

AbstractAfter the financial crisis of 2008, central banks around the world have increased their communication efforts to reach consumers, with the aim of both guiding and anchoring their inflation expectations. For the expectations channel of monetary policy to work as intended, central banks need a thorough understanding of the formation process of expectations by the general public and of the relationship between expectations and economic choices. This warrants reliable and detailed data on consumers' expectations of macroeconomic variables such as inflation or interest rates. We, thus, survey the available survey data and issues regarding the measurement of macroeconomic expectations. Furthermore, we discuss the research frontier on important aspects of the expectations channel: We evaluate the evidence on whether expectations are formed consistently with standard macroeconomic relationships, discuss the insights with respect to the anchoring of inflation expectations, explore the role of narratives and preferences and lastly, we survey the research on causal effects of central bank communication on expectations and economic choices.
Characterization of the toll‐like receptor 13 homologs in American bullfrogs, Lithobates catesbeianus, and their involvement in antimicrobial immunity
Authors: Yang Peikui , Aweya Jude Juventus , Guo Lifan , Yang Yalei , Ye Xuelian , Yang Hao , Liu Yaqun , Zheng Yuzhong 
Published: October 2023

AbstractToll‐like receptors (TLRs) are an important family of pattern‐recognition receptors that recognize a series of pathogen‐associated molecular patterns to trigger the host immune response. In the present study, we identified three TLR13 genes (i.e., LcLTR13a, LcTLR13b, and LcTLR13c) in American bullfrogs, Lithobates catesbeianus, and explored their constitutive and pathogen‐induced expression profile in different tissues. The open reading frames of LcLTR13a, LcTLR13b and LcTLR13c are 2811, 2844, and 2814 bp long, encoding 955, 947, and 933 amino acids, respectively. Phylogenetic analysis showed that three LcTLR13 genes grouping in different subclades indicate the gene duplication of bullfrog TLR13 as in teleost. The three LcTLR13 genes were expressed in all the tissues examined, with the liver and spleen expressing the higher levels. Moreover, the expression levels of LcLTR13a, LcTLR13b, and LcTLR13c were significantly induced in the liver and spleen after bullfrogs were challenged with bacterial (i.e., Citrobacter freundii, Aeromonas hydrophila, and Edwardsiella tarda) pathogens. These results indicate that LcTLR13 genes play an essential role in the bullfrog antibacterial innate immune response, providing new insights into immune mechanisms of bullfrogs.
Reference dependence and endogenous anchors
Authors: Guasoni Paolo , Meireles‐Rodrigues Andrea 
Published: October 2023

AbstractIn a complete market, we find optimal portfolios for an investor whose satisfaction stems from both a payoff's intrinsic utility and its comparison with an endogenous reference as modeled by Kőszegi and Rabin. In the regular regime, arising when reference dependence is low, the marginal utility of the optimal payoff is proportional to a twist of the pricing kernel. High reference dependence leads to the anchors regime, whereby investors reduce disappointment by concentrating significant probability in one or few fixed outcomes, or “anchors.” Multiple equilibria arise because anchors may not be unique. If stocks follow geometric Brownian motion, the model implies that investors with longer horizons choose larger stocks holdings.
Milk coagulation and gastric emptying in women experiencing gastrointestinal symptoms after ingestion of cow's milk
Authors: van Eijnatten Elise J. M. , Camps Guido , Guerville Mathilde , Fogliano Vincenzo , Hettinga Kasper , Smeets Paul A. M. 
Published: October 2023

AbstractBackgroundGastrointestinal symptoms after drinking milk are often attributed to lactose intolerance or cow's milk allergy. However, some individuals without either condition still report gastrointestinal symptoms after drinking milk. This may be caused by gastric emptying (GE) rate or gastric protein coagulation. This study aimed to compare GE rate and protein coagulation after milk consumption between individuals reporting gastrointestinal symptoms and those without symptoms using a novel gastric MRI approach.MethodsThirty women were included in this case–control study, of whom 15 reported gastrointestinal symptoms after drinking milk and 15 were controls. Participants underwent gastric MRI before and up to 90 min after consumption of 250 mL cow's milk. Gastric content volume and image texture of the stomach contents were used to determine GE and changes in the degree of coagulation.Key ResultsGE half‐time did not differ between the groups (gastrointestinal symptom group 66 ± 18 min; control group 61 ± 14 min, p = 0.845). The gastrointestinal symptom group reported symptoms from 30 min onwards and rated pain highest at 90 min. The control group reported no symptoms. Image texture analyses showed a significantly higher percentage of coagulum and lower percentage of liquid in the group in the GI symptom group (MD 11%, 95% CI [3.9, 17], p = 0.003). In vitro data suggests that pH and proteolytic enzyme activity influence the coagulum structure.Conclusions and InferencesGastric milk coagulation and emptied fraction of stomach content may differ between individuals experiencing symptoms after milk consumption, possibly due to differences in pH and proteolytic enzyme activity.