bluuebunny/crossref_metadata_2025_split huggingface dataset:
Focal Chronic Inflammatory Demyelinating Polyneuropathy – Clinical application and validation of 2021 EAN/PNS criteria
Authors: Hiew Fu Liong , Paan Winnie Lee Mei 
Published: October 2023

Abstract
Background
The updated 2021 criteria of the European Academy of Neurology/Peripheral Nerve Society (EAN/PNS) for chronic inflammatory demyelinating polyneuropathy (CIDP) has excellent diagnostic sensitivity and specificity for typical and variants CIDP. For focal monomelic CIDP, applications of this criteria may be different compared to typical or multifocal CIDP due to limited peripheral nerves involvement.
Case presentation
We illustrate using a rare case of focal right lower limb sensori-motor CIDP on the applicability of the 2021 EAN/PNS criteria and demonstrate the practical limitations of clinical, electrodiagnostic and supporting criteria in the diagnosis of focal CIDP. Unlike typical CIDP, diagnostic hallmark of classical proximal and distal weakness is frequently absent in focal CIDP. Therefore, accuracy of clinical diagnosis is less reliable. For a confirmed diagnosis, electrodiagnostic findings require fulfilment of at least 2 demyelinating features in two different motor nerves with sensory conduction abnormalities in at least 2 nerves in the affected limb. This is difficult to achieve as all the motor nerves in the affected limb are required to meet demyelination criteria. In addition, individual nerves in the affected limbs, especially the lower limbs come with specific misdiagnosis pitfalls, making misinterpretation of demyelinating features difficult. The role of demyelination of sensory nerves is limited in improving diagnosis but additional supportive criteria improved diagnostic certainty.
Conclusion
The updated EAN/PNS diagnostic criteria for focal CIDP has its own limitations on both clinical and electrodiagnostic grounds. The inclusion of supportive criteria improves diagnostic certainty, but the reliability and accuracy require future study.
Postoperative brainstem cavernous hemangioma complicated with LGI1 encephalitis and hypertrophic olivary degeneration: A case report and literature review
Authors: Zhu Ling , Han Yongsheng , Zhang Liangjie , Xu Yin , Wang Xun , Jin Huizhu 
Published: October 2023

Abstract
Background: This article reports the case of a patient with postoperative brainstem cavernous hemangioma complicated with anti-leucine-rich glioma-inactivated 1 (LGI1) encephalitis and hypertrophic olivary degeneration (HOD) to raise awareness of clinicians regarding LGI1 encephalitis and HOD.
Case presentation: We retrospectively analyzed the case data of a young male admitted to our hospital in 2022, with complaints of recurrent dizziness and headache. Based on the findings of craniocerebral computed tomography, the patient was diagnosed to have brainstem cavernous hemangioma, and he underwent surgical resection of the tumor. He subsequently developed unexplained abnormal mental behavior 1 month after the surgery. Laboratory examination revealed a positive result for anti-LGI1 antibodies in the serum and cerebrospinal fluid. Electroencephalography showed slow wave alterations in the right occipital lobe and the mesial and posterior temporal lobes. These findings confirmed the diagnosis of LGI1 encephalitis. The patient underwent immunotherapy and symptomatic treatment, and his health significantly improved. Six months later, cranial MRI showed HOD.
Conclusions: The complication of brainstem cavernous hemangioma with LGI1 encephalitis and HOD after surgical resection is an extremely rare case, and a complex mechanism underlies the occurrence of this complication. Hence, clinicians must focus on early detection and treatment of this complication to achieve a better patient prognosis.
Implementing the organizational readiness for change (ORIC) survey during a novel midwifery preceptor program in Sierra Leone: Stakeholder results
Authors: de Water Brittney van , Longacre Ashley , Hotchkiss Jenny , Sonnie Mustapha , Mann Julie , Lemor Elizabeth 
Published: October 2023

Abstract

Background
Sierra Leone has one of the world’s highest maternal and infant mortality rates and suffers from a shortage of well-trained health professionals, including midwives. Prior to engaging in systematic interventions, it is critical to measure organizational readiness to gauge members’ psychological and behavioral preparedness to implement change. We aimed to measure the organizational readiness for implementing change of healthcare workers and administrative leaders at two schools of midwifery in Sierra Leone prior to the rollout of a midwifery preceptor program.
Methods
The Organizational Readiness for Implementing Change (ORIC) survey is a validated 12-item questionnaire designed to assess two domains of organizational readiness for change: change commitment (motivation) and change efficacy (capacity). All survey items begin with the same prompt and a five-item Likert scale response, with seven questions about change commitment and five about change efficacy. Data collection occurred in two schools in Sierra Leone during two day-long meetings with stakeholders. Statistical analysis was conducted using descriptive statistics and Wilcoxon rank-sum test to compare independent samples: School 1 versus School 2 (site), midwife versus other roles (role).
Results
Participants included 42 respondents (mean age 41 years, 95% female). Surveys were distributed evenly between the two sites. Occupations included midwifery faculty (n = 8), administrators (n = 5), clinicians (n = 25), and clinical educators (n = 4). Domain 1 (change commitment) had a mean score of 4.72 (SD 0.47) while Domain 2 (change efficacy) had a mean score of 4.53 (SD 0.54) out of a total potential score of five. There were no statistically significant differences between site responses for Domain 1 (p = 0.5479) and Domain 2 (p = 0.1026) nor role responses for Domain 1 (p = 0.0627) and Domain 2 (p = 0.2520).
Conclusion
Stakeholders had very high overall readiness for change across all ORIC questions for both change commitment and change efficacy. Mean scores for change commitment were slightly higher which is not surprising given the low-resourced settings stakeholders work in while training students. High mean scores across sites and roles is encouraging as this novel preceptor program is currently being rolled out.
Thermal explosion problem with a stochastic boundary: quasi-stationary approximation and direct numerical modelling
Authors: Donskoy Igor 
Published: October 2023

Abstract
This paper investigates a stochastic modification of the Frank-Kamenetsky problem of exothermic reaction development in a flat layer with random temperature fluctuations at the outer boundary. Ignition conditions are estimated in a quasi-stationary approximation. The equation of unsteady heat transfer in a reacting medium is solved numerically for a large number of random realizations. The results of a comparison of the two approaches show that the nonstationary development of a thermal explosion in a stochastic environment can be approximated by quasi-stationary estimates with correction of the critical temperature. The distribution of ignition characteristics (ignition temperature, maximum ambient temperature, ignition time) is discussed and their dependence on the input parameters is studied.
Effect of micro-friction stir welding parameters on the mechanical properties and microstructure of 5052 aluminum thin sheets
Authors: Hwang Yeong-Maw , Lu Cheng-Yu , Chen Ren-Yu 
Published: October 2023

Abstract
This study examined micro-friction stir welds in aluminum alloys 5052-0 and 5052-H32, using 0.8 mm thick sheets. The analysis aimed to evaluate weld heterogeneity across various process parameters through microstructural examination and tensile testing. The findings suggested that elevated rotational speeds cause more heat input, resulting in adequate energy for grain growth within the stirred zone. A substantial number of equiaxed crystals that were less than 5 μm in size were observed in the stirred zone. Moreover, the number of these crystals increased with an increase in the rotational speed. The interaction of high strain rate and heat input promotes grain growth, but its effect is limited by grain size and agitator pin speed. The yield strength joining efficiencies of 5052-O and 5052-H32 range from 136% to 156% and 103% to 112%, respectively. Similarly, the tensile strength joining efficiencies range from 75% to 82% and 92% to 100%, respectively. The micro friction stir welding parameter was found to provide superior properties compared to conventional thick plate friction stir welding.
Intestinal metabolomics in premature infants with late-onset sepsis
Authors: Liu Jingfei , Zhang Li , Li Dong , Yu Xiaotong , Gao Ying , Zhou Ying 
Published: October 2023

Abstract
We aimed to investigate the characteristics of intestinal metabolomics and non-invasive biomarkers for early diagnosis of late-onset sepsis (LOS) by analyzing gut metabolites in preterm infants with LOS. We collected stool samples from septic and healthy preterm infants for analysis by liquid chromatography-mass spectrometry (LC-MS). 123 different metabolites were identified and 13 pathways were mainly involved. Glycine, serine, and threonine metabolism; glyoxylate and dicarboxylic acid metabolism; glutathione metabolism; primary bile acid biosynthesis; steroid synthesis; pentose and glucuronic acid interconversion may be involved in the pathogenesis of LOS in preterm infants. The significant expression of N-Methyldopamine, cellulose, glycine, gamma-Glutamyltryptophan, N-Ribosylnicotinamide and 1alpha, 25-dihydroxycholecalciferol showed specific diagnostic values and as non-invasive biomarkers for LOS.
Comparison of the Antibacterial Properties of Resin Cements with and without the addition of Nanoparticles: A Systematic review and Meta-analysis
Authors: Saini Ravinder , Vaddamanu Sunil Kumar , Kanji Masroor Ahmed , Quadri Syed Altafuddin , Hassan Saeed Awod Bin , Anil Sukumaran , Shrivastava Deepti , Srivast Kumar Chandan 
Published: October 2023

Abstract

Resin cement exhibits numerous therapeutic advantages in comparison to conventional luting materials. However, the effectiveness of its antibacterial properties remains uncertain. Nanotechnology provides a viable option, whereby the integration of nanoparticles (NPs) can potentially augment the antibacterial effectiveness of resin cement. The objective of this study is to conduct a comprehensive literature review and do a meta-analysis in order to assess the antibacterial effectiveness of incorporating nanoparticles into resin cement. A comprehensive search of the PubMed and Scopus databases up to September 12, 2023 was conducted in order to identify relevant scholarly articles that have examined and evaluated the antibacterial effectiveness of resin cement with and without the incorporation of nanoparticles (NPs). The systematic review and meta-analyses adhered to the PRISMA guidelines for reporting. The study was conducted using Review Manager (RevMan) version 5.4, and the results were evaluated and provided in terms of standardized mean difference (SMD) along with a matching 95% confidence interval. (CI). The search retrieved seven eligible studies. The analysis found that resin cement with NPs significantly reduced the colony forming unit (CFU) counts compared to resin cement without NPs (SMD = -4.91, 95% CI (-7.03, -2.78), P < 0.00001). Furthermore, resin cement, in addition to NPs, significantly reduced bacterial metabolic activity compared to the control group (SMD = -7.05, 95% CI (-10.43, -3.66), P < 0.0001). The use of nanoparticles (NPs) in resin cement has been shown to enhance its antibacterial properties, possibly mitigating the occurrence of secondary caries. Future clinical trials are required to validate the beneficial effects of NPs in conjunction with resin cement in the prevention of secondary caries.
Quantifying Green Hydrogen Cost Reduction from Policy-Induced Industrial Demand-pull and Offshore Wind Integration
Authors: McLaughlin Sandy , Oluleye Gbemi 
Published: October 2023

Abstract
Green hydrogen produced via curtailed offshore wind (OSW)-powered electrolysis offers a solution to bridge the gap between a rapidly expanding renewable energy capacity and the hard-to-abate industrial sector as a net zero emission fuel and feedstock. However, the cost of green hydrogen remains too elevated to compete with blue and grey hydrogen. A novel multi-layer methodology (consisting of an energy flow balance between green hydrogen supply and demand, and a temporal market penetration assessment model) is developed to assess whether the use of curtailed OSW and exploitation of industrial demand – incentivised by market-based policy – are sufficient to narrow the cost disparity between green hydrogen and its alternatives from 2025 through 2050. The method devises a policy mix (consisting of grants, emissions trading, and subsidy) for triggering a maximum and realistic green hydrogen cost reduction. The model was applied to a UK case study and findings show that (1) even when the supply of green hydrogen from curtailed OSW is insufficient to meet industrial demand, requiring complementary dedicated resources, a cost reduction of 6.76–18.76% is still possible, and (2) an optimal policy mix of the Emissions Trading Scheme and Subsidy – Low Carbon Hydrogen Production Business Model can establish cost competitiveness from 2025 onwards, exemplifying the commensurate relationship between demand-pull and cost reduction due to learning by doing and economies of scale. Ultimately results show that with effective policy support industrial demand can be exploited to reduce the cost of green hydrogen.
Benefits of an Optimal Policy-Induced Diffusion Pathway for Green Hydrogen Uptake in Refineries Globally
Authors: Rtabi Abla , Oluleye Gbemi 
Published: October 2023

Abstract
Decarbonising the oil refining industry is becoming increasingly urgent in realising a sustainable future as this sector is responsible for 4% of global greenhouse gas emissions. Replacing grey hydrogen used as feedstock for hydrotreating and hydrocracking, by green hydrogen, could significantly reduce these emissions. The absence of market uptake for green hydrogen is associated with its low cost-competitiveness. There is also a lack of appropriate supporting policy instruments. This work develops a novel temporal market penetration optimisation model, which aims to synthesise a cost-effective policy-induced diffusion pathway to reach 100% green hydrogen uptake in 512 refineries globally by 2050. The model determines the optimal mix of market-based policies required to reduce cost and generate demand for green hydrogen in refineries leading to further cost reductions. The model is applied to show how to further reduce total mitigation cost for government and industry by exploring diffusion pathways: an optimisation-led pathway (scenario 1) and S-shaped diffusion curve based on Rogers’ innovation diffusion theory (scenario 2). Results indicate 100% uptake can happen cost-effectively in a shorter time and 16% reduction in mitigation cost is possible with the optimisation-led pathway. A mix of carbon tax (from 27.98 $/tCO2 to 102.50 $/tCO2), contracts for difference (subsidy intensity from 300 $/tCO2 to 307.5 $/tCO2) and renewable electricity tax credit (from 0.04 $/kWh to 0.043 $/kWh) are required to replace grey with green hydrogen. Asia and North America are early adopters while the other regions are spread between early majority, late majority, and laggards.
The Impact of Macroeconomic Variables on the Contingent Built-in Inflation: Evidence from Indonesia
Authors: Sharma Prabhanshu , Yadgari Mohammad Rashed 
Published: October 2023

This paper examines the relationship between Exchange rates, GDP, and Government expenditure as macroeconomic variables on the Inflation of Indonesia which is quite struggling with increased prices of goods and services as it has been a persistent problem in Indonesia for many years. In 2023, it is so far 5.47% which is above the target set by the central bank of Indonesia of 2-4%. With the data taken from World Bank and IMF, the methodology consists of stationarity check, Cointegration analysis, and Error Correction Model to identify the long-run nexus among variables. The estimation result found that GDP is positively correlated with Inflation, Exchange rate is positively correlated with mild effects on inflation and government expenditure is negatively correlated with Inflation.
Possibilities of local therapy of recurrent candidiasis against the background of mixed vaginal dysbiosis
Authors: Borovikov I. O. , Kutsenko I. I. , Borovikova O. I. , Andreeva A. A. , Filippova L. A. , Avakimyan V. A. , Nikogda Ju. V. 
Published: October 2023

Introduction. The article describes the experience of treating patients with recurrent vulvovaginal candidosis combined with mixed vaginal dysbiosis using a variant of complex local therapy with drugs containing sertaconazole nitrate and benzyl-dimethyl-[3-(myristoylamino) propyl] ammonium chloride monohydrate.Aim. To evaluate the efficacy of local therapy in patients with recurrent vulvovaginal candidosis with underlying mixed non-specific vaginal dysbiosis.Materials and methods. A prospective open randomized clinical trial to evaluate the outcomes of treatment with drugs containing sertaconazole nitrate at a dose of 300 mg (Flucovag®, vaginal suppositories, two times with an interval of 7 days) and benzyl-dimethyl-[3-(myristoylamino)propyl] ammonium chloride monohydrate at a dose of 15 mg (Miramistin® vaginal suppositories once a day at bedtime for 10 days) in women with mixed nonspecific infectious vaginal diseases with underlying recurrent vulvovaginal candidosis (n = 68) was conducted. Methods: vaginal microbiota evaluation with AmpliPrime® Florocenosis/Bacterial vaginosis-FL PCR (NextBio LLC, Russian Federation), vaginal pH, Hay/Ison scoring criteria, antimycotic sensitivity evaluation against Candida spp. (NCCLS standards).Results and discussion. This kind of local complex therapy in patients with recurrent vulvovaginal candidosis combined with mixed vaginal dysbiosis using drugs containing sertaconazole nitrate (Flucovag®) and benzyl-dimethyl[3-(myristoylamino) propyl]ammonium chloride monohydrate (Miramistin®), followed by probiotic contamination showed high clinical (94.1 ± 2.3%) and microbiological (81.9 ± 2.1%) efficacy combined with safety and satisfactory compliance.Conclusion. A comprehensive approach to the treatment of mixed nonspecific vaginal dysbiosis with underlying recurrent vulvovaginal candidosis showed high clinical efficacy and satisfactory compliance.
A milonga como rastro da participação do negro na cultura pampiana
Authors: Cleusa Maria Gomes Graebin  , Jucelino Viçosa de Viçosa  
Published: October 2023

Um trabalho de memória possibilita que se tenha uma compreensão a respeito da trajetória de um grupo social, por meio da noção de que lembrar e esquecer são etapas de um mesmo processo; com isso, busca-se nos vestígios documentais algo capaz de fazer ressurgir algum acontecimento ou fenômeno ocorrido ao longo do tempo no âmbito de uma comunidade, de um lugar, com um determinado povo. Este artigo aborda, com base no gênero musical milonga desenvolvido na tríplice fronteira entre Brasil, Argentina e Uruguai, a inserção e a presença dos negros no Pampa, no contexto de uma tradição idealizada apenas no ser humano de cor branca, centrada na figura do gaucho/gaúcho ligado ao campo, proprietário rural, de ascendência espanhola ou portuguesa, ideário depois acrescido de alemães, italianos, entre outros, invisibilizando a presença dos povos originários e dos africanos escravizados e seus descendentes.
Hsa_circ_0001687 Function as a ceRNA to Facilitate Hepatocellular
Carcinoma Progression via miR-140- 3p/FOXQ1 Axis
Authors: You Song , Cheng Niangmei , Wang Fei , Zheng Xiaoyuan , Wang Yingchao , Zhao Bixing , Liu Jingfeng 
Published: October 2023

Background:
Increasingly convincing evidence has revealed that circular RNAs
(circRNAs) are critical regulatory components of hepatocellular carcinoma (HCC) genesis.
However, the expression of circRNAs in HCC and the relevance of circRNAs to HCC progression
remain largely unexplained.

Methods:
qRT-PCR or western blotting was utilized to confirm circ_0001687, miR-140-3p, and
Forkhead Box q1 (FOXQ1) levels in HCC tissues or cells. Cell proliferation ability was evaluated
via CCK-8 and colony formation assay. The correlation of circ_0001687 or FOXQ1 and miR-140-
3p was determined using dual luciferase reporter assay. Nude mice xenograft tumor model was
constructed to verify the effect of circ_0001687 on tumor growth.

Results:
Circ_0001687 was elevated in HCC. Function assays and the nude mice xenograft tumor
model indicated that circ_0001687 acts as a promoting gene in HCC to regulate the proliferation of
the tumor cell and foster tumor growth. Further mechanistic exploration revealed that the tumor
growth-promoting mechanism of circ_0001687 relied on blocking the inhibitory effect of miR-140-
3p on FOXQ1 and activating FOXQ1 expression.

Conclusion:
This research indicated the role of circ_0001687/miR-140-3p/FOXQ1 network in
regulating HCC development. These may provide new insights into the treatment of HCC.
Recent Updates in Inhalable Drug Delivery System against Various
Pulmonary Diseases: Challenges and Future Perspectives
Authors: Chaudhary Kabi Raj , Singh Karanvir , Singh Charan 
Published: October 2023

Abstract:
In the current scenario, pulmonary disease has become a prime burden for morbidity and
mortality alongside tremendous social and economic crises throughout the world. Numerous conventional
drug delivery system and treatment approach targeting the respiratory region has been driven
out. However, effective and accurate recovery has not been achieved yet. In this regard, nanotechnological-
based inhalable drug delivery strategy including polymeric, lipidic, or metallic-based respirable
microparticles plays an indispensable role in circumventing numerous challenges faced during
traditional treatment. Excellent aerodynamic performance leads to enhanced lung targetability, reduced
dosing frequency and hence systemic toxicities, as well as improved pharmaceutical attributes,
and therefore pharmacokinetic profiles are interminable factors associated with nanotechnologicalbased
inhalable delivery. In this review, we comprehensively explored recent advancements in nanotechnologically
engineered inhalable formulations targeting each of the mentioned pulmonary diseases.
Moreover, we systematically discussed possible respiratory or systemic toxicities about the indeterminate
and undefined physicochemical characteristics of inhaled particles.