bluuebunny/crossref_metadata_2025_split huggingface dataset:
A mixed‐methods investigation of a digital mental health tool to manage posttrauma anger
Authors: Metcalf Olivia , Pham Le , Lamb Karen E. , Zaloumis Sophie , O'Donnell Meaghan L. , Qian Tianchen , Varker Tracey , Cowlishaw Sean , Forbes David 
Published: January 2025

AbstractProblematic anger affects up to 30% of individuals who have experienced trauma. Digital mental health approaches, such as ecological momentary assessment (EMA) delivered via smartphone and wearable devices (i.e., wearables), hold significant potential for the development of novel digital technology treatments. The objective of this cohort study was to examine the acceptability, feasibility, and outcomes from 10 days of usage of a digital mental health tool combining EMA and wearable use among trauma‐exposed adults with problematic anger. We used mixed methods to examine feasibility and acceptability and explored quantitative changes in mental health symptoms among participants over the study period (N = 98, 80.4% women, Mage = 38 years). Quantitative and qualitative data revealed that regular EMA combined with a wearable was feasible and acceptable in the sample. We observed reductions in problem anger, p < .001, repeated‐measures d (dRM) = ‐0.81, 95% CI [‐1.04, ‐0.59]; and posttraumatic stress disorder symptoms, p = .025, dRM = ‐0.26, 95% CI [‐0.55, ‐0.03], over the 10 days of monitoring. Qualitative findings suggest that by regularly “checking in” on anger symptoms, participants improved their self‐awareness and ability to self‐manage their mood. These findings provide valuable learnings for building future personalized digital mental health tools.
Quercetin Reduces the Susceptibility to Cardiac Reperfusion Arrhythmias in Ovariectomized Rats
Authors: Domingos Ainá E. , Breves Cíntia M. da Costa , Boa Luiz F. , de Souza Itanna I. A. , Maciel Leonardo , Seara Fernando A. C. , Fortunato Rodrigo S. , Nascimento Jose H. M. 
Published: January 2025

ABSTRACTCardiovascular diseases (CVDs) are the leading cause of death globally. Decrease in female sex hormones during menopause increases the risk of cardiovascular disease, mainly ischemic heart disease (IHD). Quercetin, a flavonoid, has beneficial properties in CVDs due to its antioxidant, anti‐inflammatory, and anti‐apoptotic effects. The aim of this study was to investigate the effects of quercetin on susceptibility to cardiac reperfusion arrhythmias and mitochondrial function in ovariectomized rats (OVX). Three‐month‐old Wistar female rats were randomly assigned to the following experimental groups: SHAM‐operated, vehicle‐treated (DMSO 10% + PBS, 1 mL kg−1); OVX (vehicle‐treated); and OVX+Q (25 mg·kg−1). The three experimental groups were carried out for 4 weeks (five times a week) by oral gavage. Quercetin treatment effectively decreased myocardial infarct size and susceptibility to reperfusion arrhythmias. Quercetin treatment was also effective in preventing mitochondrial swelling, while increased ATP production compared to the OVX group. In conclusion, our results indicate that quercetin could have a therapeutic effect in preventing some of the pathophysiological changes caused by low estrogen levels in the cardiovascular system.
Wideband Circularly Polarized Conformal Dielectric Resonator Antenna for High Gain Applications
Authors: Parvathi V. L. , Rajput Anil , Raut R. B. , Mukherjee Biswajeet 
Published: January 2025

ABSTRACTA compact and circularly polarized convex dielectric resonator antenna (CDRA) is investigated in this communication. Eigenmode method is used to analyze electromagnetic field propagation and resonant frequency of the antenna. Benefits of conformal structure over a planar surface are mentioned. A pair of vertical slots are introduced on the ground plane to produce orthogonal degenerate modes. Finally, the proposed curved DRA provides a fractional impedance bandwidth of 22%, axial ratio bandwidth of 11.27% and a stable gain of more than 5 dBi over the desired passband with a peak gain of 7 dBi. To validate the simulated results, a prototype is fabricated and measured.
Concurrent Nasal Symptoms in Non‐Rhinogenic Headache
Authors: Jang David W. , Wang Avivah J. , Hachem Ralph Abi , Goldstein Bradley J. , Witsell David L. , Godley Frederick , Jiang Rong 
Published: January 2025

AbstractObjectiveThis study aims to characterize concurrent nasal symptoms in a cohort of patients with non‐rhinogenic headache (NRH) presenting to an otolaryngology clinic.Study DesignA prospective cohort.SettingSingle tertiary care institution.MethodsAdults with NRH were recruited over a 2‐year period (February 2021 to February 2023). Patients were eligible if they endorsed midfacial pain or pressure for at least 10 days a month over the previous 3 months and had no evidence of rhinosinusitis on both nasal endoscopy and computed tomography imaging. Study participants used a mobile application to keep a daily log of their facial pain/pressure, nasal congestion, and nasal mucus/discharge. Symptom severity was scored on a scale from 1 (none) to 10 (worst) for 30 consecutive days. Repeated measures correlation coefficients were calculated to evaluate overall or common intra‐individual association for each symptom.ResultsTwenty‐eight patients were enrolled, and they completed the 30‐day symptom log. Median (range) scores were 5 (1‐10), 4 (1‐10), and 2 (1‐10) for facial pain/pressure, congestion, and mucus, respectively. Patients had significant day‐to‐day fluctuations in scores for all 3 symptoms, with a significant positive correlation between symptoms: congestion/mucus (r = 0.74181, P < .0001), congestion/facial pain (r = 0.5873, P = .001), and mucus/facial pain (r = 0.49384, P = .0076).ConclusionPatients with NRH often have concurrent nasal symptoms. Moreover, nasal congestion, mucus, and facial pain/pressure had significant correlations in day‐to‐day fluctuations in severity. Our findings suggest the possibility that all three symptoms share a common pathophysiology.
Characteristics analysis of failure envelope for fiber‐reinforced plastic and its dependence on the ratio of uniaxial strength
Authors: Zhang Shufeng , Pang Xiaofei , Song Guofeng , He Yonglyu , Huang Liwen , Chen Xun 
Published: January 2025

AbstractThis study investigates the characteristics of the FRP failure envelope under combined compression‐shear loading, basing on experimental, theoretical and simulation analysis. The observed discrepancies in the PUCK criterion are shown to depend heavily on the ratio of transverse compressive strength to longitudinal shear strength. Meanwhile, the representative volume element (RVE) models are employed to analysis microscale factors influencing the FRP failure envelope. The results indicate that the failure envelope is significantly influenced by the interface reinforcement coefficient, which is strongly correlated with the ratio of uniaxial compressive strength to shear strength. The significance of this ratio lies in its macroscopic reflection of the interface reinforcement coefficient, and errors can be decreased by modifying the failure criterion according to this ratio. This main finding of this work is to reveal the dependence of the FRP failure envelope on the ratio of uniaxial strengths. On this basis, the optimal values for the inclined angle parameters in the PUCK failure criterion are proposed in relation to FRPs with varying interface reinforcement coefficients, which offering valuable insights for improving the accuracy of FRP failure predictions.Highlights
The interface reinforcement coefficient can influence biaxial failure envelope.
Improving the slope parameter can considerably lower the prediction error.
Dependence of failure envelope on the ratio of uniaxial strength was clarified.
Thermoplastic‐based composites from treated Arenga pinnata (Wurmb.) Merrill. fibers: A bibliometric analysis and literature review on dynamic mechanical analysis
Authors: Khoo Pui San , Muhammad Rizal Muhammad Asyraf , Nordin Abu Hassan , Ashraf Waqas , Hazrati Kamaruddin Zatil , Lee Seng Hua , Rafidah Mazlan 
Published: January 2025

AbstractThe decline in petroleum resources has motivated researchers to explore Arenga pinnata (Wurmb.) Merrill. or sugar palm fiber (SPF), a promising lignocellulosic fiber from Southeast Asia, particularly Malaysia, in biocomposite applications. SPF primarily comprises cellulose, which provides excellent mechanical properties for domestic products, including brushes, ropes, twine, roofs, and brooms. Numerous studies have investigated SPF‐reinforced thermosetting and thermoplastic composites' thermal, physical, and mechanical properties, investigating factors such as stacking sequence, chemical treatment, fiber size, loading, and orientation. However, a comprehensive review of the dynamic mechanical performance of Arenga pinnata (Wurmb.) Merrill. composites are still lacking. As a result, this review provides a comprehensive bibliometric analysis coupled with a literature review focused on thermoplastic‐based composites utilizing SPFs. This study systematically evaluates the evolution of research in this domain by analyzing publication trends, citation networks, and key contributors over the past two decades. Furthermore, the review highlights critical advancements in the treatment methods of SPFs, their incorporation into thermoplastic matrices, and the subsequent effects on dynamic mechanical properties, specifically focusing on storage modulus, loss modulus, and damping behavior. This review aims to expand current knowledge on the dynamic mechanical behavior of SPF‐reinforced thermoplastic biocomposites for engineering applications.Highlights
SPF is a promising fiber from Southeast Asia, particularly Malaysia.
SPF primarily consists of cellulose, which exhibits excellent mechanical properties.
DMA is the preferred method to reveal details about heterogeneous biocomposite systems.
Optimal SPF is effective in restricting molecular chain mobility to improve DMA performance.
Hybrid SPF with other fibers in sequence improves biocomposites' DMA performance.
Coumarins in the Flavedo of Citrus limon Varieties—Ethanol and Natural Deep Eutectic Solvent Extractions With HPLC‐DAD Quantification
Authors: Alperth Fabian , Pogrilz Bettina , Schrammel Astrid , Bucar Franz 
Published: January 2025

ABSTRACTIntroductionPeels are an abundant but still underutilized waste product in the Citrus fruit industry. They contain coumarins with antiadipogenic potential that could be promising targets in new valorization strategies for Citrus peels.ObjectivesIn this study, these coumarins, that is, citropten, bergamottin, and 5‐geranyloxy‐7‐methoxycoumarin (5G7MC), were investigated in Citrus limon peels of different commercial varieties by HPLC‐DAD after extraction with ethanol and choline chloride‐based natural deep eutectic solvents (NADES) as alternative extraction agents in green natural product extraction.ResultsTarget coumarins were almost exclusively found in the flavedo (exocarp) peel layer and in whole peel samples, but not in the albedo (mesocarp) layer. Flavedo samples from varieties “Verdelli” (ES) and “Lisbon” (ZA) showed particularly high concentrations in ethanolic extracts. When applying NADES extraction, best results for citropten were achieved with malonic acid, 1,2‐propanediol, and citric acid as hydrogen bond donors (HBDs), with higher yields than the reference solvent ethanol. For bergamottin and 5G7MC, promising results were obtained for 1,2‐propanediol as HBD, though lower yields than with ethanol. The possible chlorination of coumarin epoxides byakangelicol and oxypeucedanin was recognized for acidic NADES in LC–MS analysis.ConclusionOverall, C. limon peels proved to be a relevant starting material for valorization through coumarin extraction with ethanol and NADES.
Intramuscular methylergonovine to decrease blood loss during cesarean delivery for twins: A triple‐blinded placebo‐controlled randomized trial
Authors: Gomez Slagle Helen B. , Miller Russell , Bejerano Shai , Goffman Dena , D'alton Mary E. , Mourad Mirella 
Published: January 2025

AbstractObjectiveOur objective was to evaluate whether prophylactic administration of intramuscular (IM) methylergonovine after cord clamping reduces blood loss during planned cesarean delivery (CD) of twin pregnancies.MethodThis single‐center randomized placebo‐controlled triple‐blinded trial compared the effects of IM methylergonovine versus saline placebo control on maternal blood loss at CD. Pregnant individuals with twin gestations at ≥ 34 weeks of gestation undergoing planned CD were enrolled. Methylergonovine or saline placebo was administered immediately after umbilical cord clamping of the second twin in addition to standard oxytocin prophylaxis. The primary outcome was a change in mean maternal hemoglobin (Hgb) level from preoperative to postoperative day 1 (POD 1). Secondary outcomes include intraoperative blood loss, additional uterotonic use, and rates of postpartum hemorrhage and transfusion. We planned to enroll 66 patients to detect a standard deviation (SD) greater drop in postoperative maternal Hgb, assuming −1.40 (± 0.83) g/dL Hgb difference after planned CDs (90% power, alpha 0.05). Pearson chi‐square test, Fisher's exact test, t‐test, and Wilcoxon rank sum test with intent‐to‐treat principles were performed as appropriate. A linear regression model was performed on the primary outcome.ResultsA total of 66 patients (33 methylergonovine and 33 placebo) were randomized. There were no demographic differences between methylergonovine and placebo groups. Median gestational age at delivery was 37 weeks for both groups. Mean Hgb drop on POD 1 was 1.1 g/dL (SD 0.7 g/dL) for methylergonovine and 2.1 g/dL (SD 0.9 g/dL) for placebo (p < 0.001). Quantitative blood loss was significantly lower in patients receiving prophylactic methylergonovine (891 vs. 1017 mL, p = 0.003). Postpartum hemorrhage rates were lower in the methylergonovine group (18.2% vs. 54.5%, p = 0.002). There were seven cases of unblinding due to hemorrhage in the placebo group compared to no cases in the methylergonovine group (p = 0.01); all unblinded subjects received methylergonovine.ConclusionProphylactic IM methylergonovine administered after umbilical cord clamping during twin CD significantly reduced intraoperative blood loss and hemoglobin drop on POD 1. These data support further study of methylergonovine as a preventative treatment strategy at the time of twin CD.
Increase in IAA levels by EPSPS copy number variation relates to fitness advantage in Eleusine indica
Authors: Chen Jingchao , Cui Hailan , Li Zhiling , Yu Haiyan , Yu Qin , Li Xiangju 
Published: January 2025

AbstractBACKGROUNDLong‐term use of chemical weed control has led to some weedy species evolving herbicide resistance traits with fitness advantage. Our previous studies revealed glyphosate resistance in an Eleusine indica population due to copy number variation of 5‐enolpyruvylshikimate‐3‐phosphate synthase (EPSPS) comes with fitness advantage under non‐competitive conditions. Here, transcriptomics and targeted metabolomics were used to investigate physiological basis associated with the fitness advantage.RESULTSRelative copy number of EPSPS gene and plant dry weight of the glyphosate‐resistant (R) population was 88.3‐ and 1.2‐ times, respectively, higher than that in the wild type (WT) plants that were isolated from within the R population. Seven genes were screened to be relevant to fitness growth trait by RNA‐seq. The level of aromatic amino acids Tryptophan (Trp), Phenylalanine (Phe) and Tyrosine (Tyr), products in the shikimate pathway catalyzed by EPSPS, was 1.2‐times higher in R compared to the WT plants. The metabolites associated with Trp metabolism indole‐3‐acetic acid (IAA), 3‐indolepropionic acid (IPA), indole‐3‐acetamide (IAM) in the R plants were 2.0‐, 1.8‐ and 1.4‐ times higher than that in the WT plants, respectively.CONCLUSIONAll the results indicate that fitness advantage in the studied R E. indica population may be caused by higher IAA production due to over‐expression of the EPSPS gene and pleiotropically by elevated carbon metabolism. The findings in this research can provide reference information for control strategies to the glyphosate‐resistant E. indica. © 2025 Society of Chemical Industry.
Right Heart Catheterization Accurately Diagnoses Pulmonary Hypertension in Patients With Interstitial Lung Disease: Results From a Long‐Term Cohort Study
Authors: Torres‐Rojas María Berenice , Navarro‐Vergara Dulce Iliana , García‐Cesar Marisol , Acosta‐Altamirano Gustavo , González‐Hermosillo Leslie Marisol , Escobedo Galileo , Cueto‐Robledo Guillermo 
Published: January 2025

ABSTRACTInterstitial lung disease (ILD) can lead to pulmonary hypertension (ILD‐PH), worsening prognosis and increasing mortality. Diagnosing ILD‐PH is challenging due to the limitations of imaging methods. Right heart catheterization (RHC) is the gold standard for diagnosing PH but is limited to ILD patients considered for lung transplantation. This study assessed the usefulness of RHC in diagnosing ILD‐PH in a large cohort of 105 patients followed for at least 72 months, examining hemodynamic parameters for survival analysis. We conducted an ambispective cohort study, diagnosing PH as mean pulmonary artery pressure ≥ 20 mmHg, pulmonary arterial wedge pressure < 15 mmHg, and pulmonary vascular resistance > 2 Wood units by RHC. We registered demographic, biochemical, echocardiographic, respiratory, and hemodynamic parameters for survival analyses. Using RHC, we found a PH prevalence of 84.7% among ILD patients who previously exhibited an intermediate‐to‐high probability of PH by echocardiography. Thirty‐nine ILD‐PH patients died, yielding a 5‐year survival rate of 35%, whereas ILD patients without PH had a survival rate of 100%. Connective tissue disease‐associated ILD and interstitial pneumonia with autoimmune features were the predominant ILD subtypes in ILD‐PH patients. The ILD‐PH group had worse pulmonary function, lower forced vital capacity, and more severe hypoxemia. Kaplan–Meier analyses showed significantly lower survival rates in ILD‐PH patients with a 6‐min walking distance < 360 m, tricuspid annular plane systolic excursion/pulmonary artery systolic pressure ratio < 0.35 mm/mmHg, venous oxygen saturation < 65%, and pulmonary artery compliance < 2.2 mm/mmHg. RHC accurately characterizes ILD‐PH and provides long‐term survival predictors.
Distributed Optimization for Heterogenous Multi‐Agent Systems Under DoS Attacks: Resilient Double‐Layer Sampling Filtering Framework
Authors: Wu Han‐Yu , Liu Qingshan , Park Ju H. 
Published: January 2025

ABSTRACTThis paper investigates the distributed optimization for heterogenous multi‐agent systems (MASs) under zero‐topology Denial‐of‐Service (DoS) attacks, where the attacks are launched within the communication channels. A novel filtering attack framework is proposed based on the periodic sampling and event‐triggering mechanism to counteract the impact of the attacks. Under this framework, the consumption of communication resources is reduced, and the minimum lower boundary of triggering time can be obtained to avoid the occurrence of Zeno behavior. Moreover, the relationship between the equilibrium point and optimal solution of heterogenous MASs under DoS attacks is revealed by employing a proportional‐integral strategy. Furthermore, constructing an auxiliary system guarantees the output consensus and global exponential convergence of the MAS. Finally, a simulation example is provided to show that the proposed approach has a faster convergence rate and better robust performance against DoS attacks.
Bayesian Analysis of Censored Linear Mixed‐Effects Models for Heavy‐Tailed Irregularly Observed Repeated Measures
Authors: Zhong Kelin , Schumacher Fernanda L. , Castro Luis M. , Lachos Víctor H. 
Published: January 2025

ABSTRACTThe use of mixed‐effect models to understand the evolution of the human immunodeficiency virus (HIV) and the progression of acquired immune deficiency syndrome (AIDS) has been the cornerstone of longitudinal data analysis in recent years. However, data from HIV/AIDS clinical trials have several complexities. Some of the most common recurrences are related to the situation where the HIV viral load can be undetectable, and the measures of the patient can be registered irregularly due to some problems in the data collection. Although censored mixed‐effects models assuming conditionally independent normal random errors are commonly used to analyze this data type, this model may need to be more appropriate for accommodating outlying observations and responses recorded at irregular intervals. Consequently, in this paper, we propose a Bayesian analysis of censored linear mixed‐effects models that replace Gaussian assumptions with a flexible class of distributions, such as the scale mixture of normal family distributions, considering a damped exponential correlation structure that was employed to account for within‐subject autocorrelation among irregularly observed measures. For this complex structure, Stan's default No‐U‐Turn
sampler is utilized to obtain posterior simulations. The feasibility of the proposed methods was demonstrated through several simulation studies and their application to two AIDS case studies.
Hydrogen‐Bonded Organic Framework Films Integrated with Wavy Structured Design for Wearable Bioelectronics
Authors: Yang Xue , Huang Tao , Gao Chang , Wu Peiru , Hu Zhiqi , Wu Lingling , Jia Haonan , Li Qingsong , Li Qian , Wang Chengyu , Zhao Robert Chunhua , Cao Rong 
Published: January 2025

AbstractThe integration of hydrogen‐bonded organic frameworks (HOFs) with flexible electronic technologies offers a promising strategy for monitoring detailed health information, owing to their inherent porosity, excellent biocompatibility, and tunable catalytic capabilities. However, their application in wearable and real‐time health monitoring remains largely unexplored, primarily due to the mechanical mismatch between the traditionally fragile HOFs particles and the softness of human skin. Herein, this study demonstrates an epidermal biosensor that maintains reliable sensing capability even under extreme deformation and complex environmental conditions by integrating HOFs films with wavy bioelectrodes. This wearable biosensor demonstrates ultrasensitive detection capabilities, with a limit of detection of 49.64 nM, and accurately measures nutritional content in sweat while conforming to curved skin surfaces. The sensor's performance is comparable to those obtained using high‐performance liquid chromatography (HPLC). More strikingly, scratched HOFs films can be regenerated through a simple solvent rinsing process, enabling their reuse in the fabrication of new biosensors and offering a significant advantage over conventional sensing materials. This work has the potential to inspire the development of more flexible electronic devices, leveraging the structural adaptability and diversity of HOFs for personalized healthcare applications and real‐time health monitoring.