bluuebunny/crossref_metadata_2025_split huggingface dataset:
Perceived disrespectful treatment in low-income healthcare settings through the lens of intersectionality
Authors: Snitselaar Sara , Carr Deborah 
Published: December 2023

AbstractRace and gender differences in the quality of one’s health care encounters are widely documented, but few studies explore the multiplicative impacts of race and gender. Drawing on intersectionality frameworks, we contrast white, Black, Hispanic, Asian, and Native American men’s and women’s perceptions of disrespectful treatment from health care providers and staff (e.g., receptionists, clerks) in low-income health settings. Data are from the 2014 Health Center Patient Survey (N = 5385), a nationally representative survey of community-dwelling patients receiving care at health centers funded through Section 330 of the Public Health Service Act. Our results show race and sex differences in the study outcomes, yet weak support for intersectional effects. Asian and Native American patients report more disrespectful treatment from providers, relative to other ethnic groups. Women are more likely than men to report disrespectful treatment from staff. Asians also report disrespectful treatment from staff. Health care providers and staff may require training focused on the distinctive needs of Asian patients, for whom “saving face” may be a salient goal. Structural changes to reduce wait times and employ medical interpreters to ensure clear communication, and staff training focused on verbal and nonverbal communication may mitigate against actions perceived as disrespectful in low-income health settings.
Advancing post-harvest fruit handling through AI-based thermal imaging: applications, challenges, and future trends
Authors: Pathmanaban P. , Gnanavel B. K. , Anandan Shanmuga Sundaram , Sathiyamurthy S. 
Published: December 2023

AbstractRecent advancements in imaging, electronics, and computer science have engendered significant progress in non-destructive testing and quality monitoring within the agro-food industry. This progress is particularly evident in integrating infrared thermal imaging (TI) and artificial intelligence (AI) techniques. As a non-contact method, AI-based TI holds promise in detecting various quality attributes and has found extensive applications in agriculture, food processing, and post-harvest fruit handling. This paper delves into recent applications of AI-based thermal imaging, specifically in post-harvest fruit handling. The introduction provides a comprehensive overview of the challenges faced in the post-harvest fruit handling industry while emphasizing the advantages of AI-driven thermal imaging technology. The detailed thermal imaging system encompasses both passive and active thermography techniques. This paper provides an in-depth exploration of artificial intelligence, focusing on machine learning and deep learning. It highlights the significance of convolutional neural networks (CNNs) and their architectural phases. Subsequently, critical applications of AI-based thermal imaging in post-harvest fruit quality assessment are discussed. These applications encompass bruise detection, maturity identification, condition monitoring, grading and sorting, pest and disease detection, and considerations for packaging and supply chain management. Furthermore, this paper addresses the challenges and limitations of AI-based thermal imaging in post-harvest fruit handling. In conclusion, this paper discusses future trends in AI-based thermal imaging, emphasizing the potential for increased automation and integration with emerging technologies in the post-harvest fruit handling sector. The insights provided contribute to the ongoing dialog surrounding optimizing quality assessment processes in the agro-food industry.
The role of building violations on urban spatial development in Iran: an emphasize on Tehran metropolis socioeconomic factors
Authors: Kojouri Mousa Kamanroudi , Ghalehteimouri Kamran Jafarpour , Kiadarbandsari Mahla 
Published: December 2023

AbstractBuilding code violations have negatively affected Tehran’s spatial development significantly over the last three decades. This study was carried out to answer the question of what the status and factors of building violations and spatial changes were in Tehran’s districts in the first decade 1990s and 2000s, when rapid urban development was at its peak. This study’s statistical population included all buildings in the 22 districts of Tehran. In addition, the data and information for this study were gathered through library and documentary research. Furthermore, descriptive statistical methods were used to explain and interpret the data, and Geographic Information Systems (GIS) were used to represent the results. According to the findings, financial incentives were the most important motivators for committing these violations. One of the most important spatial developments in the Tehran metropolis during this time is the conflict between the Master Plan for the city and population growth, per-capita residential, commercial, and military land use. As a result, areas 1 to 7 and residential structures accounted for 56% of Tehran’s total area of residential buildings and 41.8% of the city’s population in 2001, respectively, a rise of 2.9% and 34.8%. Additionally, other public institutions increased the area of residential buildings and the population of this area by 46.5% and 42.5% during this time period, respectively, by violating building codes, particularly in area 4 of the city.
The Doctor in Free Movement Law: Expertise, Duty, and Accountability
Authors: van Leeuwen Barend 
Published: December 2023

AbstractThis Article provides an empirical analysis of all free movement of doctors cases decided by the CJEU. The aim of the Article is twofold: to provide a ‘characterisation’ of the type of doctors who rely on free movement law, and to make a link between their reliance on free movement law and the concept of medical professionalism. In what circumstances, and with what purpose, do doctors rely on free movement law? And does their reliance on free movement law pose a risk to medical professionalism? The analysis shows that most cases before the CJEU focussed on the expertise and qualifications of doctors. Many cases were brought by groups of doctors or medical professional associations. In most cases, the aim of the doctor's reliance on free movement law was to defend medical professionalism. Nevertheless, some recent cases show that doctors do rely on free movement law to restrict their accountability towards patients or national healthcare systems. Moreover, these cases show that arguments based on free movement law are relied on in a broader range of non-specialised courts or tribunals. This makes it important that national courts continue to engage in a dialogue with the CJEU.
Feeding ecology of the shortfin mako shark, Isurus oxyrinchus, in the Ecuadorian Pacific Ocean
Authors: Calle-Morán Marcos D. , Erazo-Garcés Héctor M. , Hernández-Téllez Ana R. , Galván-Magaña Felipe , Estupiñán-Montaño Colombo 
Published: December 2023

Abstract
Shortfin mako shark, Isurus oxyrinchus, is listed as an endangered species with declining global population. Thus, studies regarding its biology and ecology are important to recommend fishery management and conservation measures. This study aimed to determine the diet composition and feeding habits of I. oxyrinchus in Ecuadorian waters. Samples were obtained from Santa Rosa fishing port (Ecuador). The total length (LT), sex and sexual characteristics were recorded, and stomach contents were collected. A total of 142 individuals were recorded, comprising 81 females (104–295 cm LT) and 61 males (127–245 cm LT). A total of 24 prey species were identified, including crustaceans, cephalopods, teleosts and cetaceans. According to the Prey-Specific Index of Relative Importance (PSIRI), the main prey taxa were the ommastrephid squid, Dosidicus gigas (42.57%) and Sthenoteuthis oualaniensis (21.04%), followed by fish from the family Hemiramphidae (11.85%). Isurus oxyrinchus is a specialist predator that preferred a low number of prey (Bi = 0.25), both by sex (Bi; females = 0.29 and males = 0.34) and life stages (Bi; juveniles = 0.27 and adults = 0.37). The trophic overlap was medium for sexes (J = 0.54) and biological cycle phases (J = 0.42). Trophic level (TLk) was 4.47, indicating that I. oxyrinchus is a tertiary predator. This information will help in fisheries management based on an ecosystem approach, where this species fulfils an ecological role, and its interactions with other species allow us to understand how the flow of nutrients and energy occurs within an ecosystem.
A dual-mode fiber-shaped flexible capacitive strain sensor fabricated by direct ink writing technology for wearable and implantable health monitoring applications
Authors: Zhang Chi , Ouyang Wenyu , Zhang Lei , Li Dachao 
Published: December 2023

AbstractFlexible fiber-shaped strain sensors show tremendous potential in wearable health monitoring and human‒machine interactions due to their compatibility with everyday clothing. However, the conductive and sensitive materials generated by traditional manufacturing methods to fabricate fiber-shaped strain sensors, including sequential coating and solution extrusion, exhibit limited stretchability, resulting in a limited stretch range and potential interface delamination. To address this issue, we fabricate a fiber-shaped flexible capacitive strain sensor (FSFCSS) by direct ink writing technology. Through this technology, we print parallel helical Ag electrodes on the surface of TPU tube fibers and encapsulate them with a high dielectric material BTO@Ecoflex, endowing FSFCSS with excellent dual-mode sensing performance. The FSFCSS can sense dual-model strain, namely, axial tensile strain and radial expansion strain. For axial tensile strain sensing, FSFCSS exhibits a wide detection range of 178%, a significant sensitivity of 0.924, a low detection limit of 0.6%, a low hysteresis coefficient of 1.44%, and outstanding mechanical stability. For radial expansion strain sensing, FSFCSS demonstrates a sensitivity of 0.00086 mmHg−1 and exhibits excellent responsiveness to static and dynamic expansion strain. Furthermore, FSFCSS was combined with a portable data acquisition circuit board for the acquisition of physiological signals and human‒machine interaction in a wearable wireless sensing system. To measure blood pressure and heart rate, FSFCSS was combined with a printed RF coil in series to fabricate a wireless hemodynamic sensor. This work enables simultaneous application in wearable and implantable health monitoring, thereby advancing the development of smart textiles.
New insights into the correlations between circulating tumor cells and target organ metastasis
Authors: Zhan Qinru , Liu Bixia , Situ Xiaohua , Luo Yuting , Fu Tongze , Wang Yanxia , Xie Zhongpeng , Ren Lijuan , Zhu Ying , He Weiling , Ke Zunfu 
Published: December 2023

AbstractOrgan-specific metastasis is the primary cause of cancer patient death. The distant metastasis of tumor cells to specific organs depends on both the intrinsic characteristics of the tumor cells and extrinsic factors in their microenvironment. During an intermediate stage of metastasis, circulating tumor cells (CTCs) are released into the bloodstream from primary and metastatic tumors. CTCs harboring aggressive or metastatic features can extravasate to remote sites for continuous colonizing growth, leading to further lesions. In the past decade, numerous studies demonstrated that CTCs exhibited huge clinical value including predicting distant metastasis, assessing prognosis and monitoring treatment response et al. Furthermore, increasingly numerous experiments are dedicated to identifying the key molecules on or inside CTCs and exploring how they mediate CTC-related organ-specific metastasis. Based on the above molecules, more and more inhibitors are being developed to target CTCs and being utilized to completely clean CTCs, which should provide promising prospects to administer advanced tumor. Recently, the application of various nanomaterials and microfluidic technologies in CTCs enrichment technology has assisted to improve our deep insights into the phenotypic characteristics and biological functions of CTCs as a potential therapy target, which may pave the way for us to make practical clinical strategies. In the present review, we mainly focus on the role of CTCs being involved in targeted organ metastasis, especially the latest molecular mechanism research and clinical intervention strategies related to CTCs.
Sociodemographic associations with uptake of novel therapies for acute myeloid leukemia
Authors: Hantel Andrew , Cernik Colin , Uno Hajime , Walsh Thomas P. , Calip Gregory S. , DeAngelo Daniel J. , Lathan Christopher S. , Abel Gregory A. 
Published: December 2023

AbstractInequitable uptake of novel therapies (NT) in non-cancer settings are known for patients with lower socioeconomic status (SES), People of Color (POC), and older adults. NT uptake equity in acute myeloid leukemia (AML) is not well known. We performed a retrospective cohort study (1/2014-8/2022) of the United States nationwide Flatiron HealthTM electronic health record-derived, de-identified database. We estimated sociodemographic associations with AML NT receipt using incidence rate ratios (IRR). Odds ratios (OR) assessed differences in venetoclax (the most common NT) receipt at community sites and between site characteristics and NT adoption. Of 8081 patients (139 sites), 3102 (38%) received a NT. NT use increased annually (IRR 1.14, 95% confidence interval [1.07, 1.22]). NT receipt was similar between Non-Hispanic-Whites and POC (IRR 1.03, [0.91, 1.17]) and as age increased (IRR 1.02 [0.97, 1.07]). At community sites, Non-Hispanic-Whites were less likely to receive venetoclax (OR 0.77 [0.66, 0.91]); older age (OR 1.05 [1.04, 1.05]) and higher area-level SES were associated with venetoclax receipt (OR 1.23 [1.05, 1.43]). Early NT adopting sites had more prescribing physicians (OR 1.25 [1.13, 1.43]) and higher SES strata patients (OR 2.81 [1.08, 7.66]). Inequities in AML NT uptake were seen by SES; for venetoclax, differential uptake reflects its label indication for older adults and those with comorbidities.
USP7 inhibits the progression of nasopharyngeal carcinoma via promoting SPLUNC1-mediated M1 macrophage polarization through TRIM24
Authors: Liu Huai , Tang Ling , Gong Sha , Xiao Tengfei , Yang Hongmin , Gu Wangning , Wang Hui , Chen Pan 
Published: December 2023

AbstractReprogramming of macrophages toward an M1 phenotype is a novel strategy to induce anticancer immunity. However, the regulatory mechanisms of M1 macrophage polarization and its functional roles in nasopharyngeal carcinoma (NPC) progression need to be further explored. Here we found that SPLUNC1 was highly expressed and responsible for M1 macrophage polarization. JAK/STATs pathway activation was involved in SPLUNC1-mediated M1 macrophage polarization. Importantly, regulation of SPLUNC1 in macrophages affected CM-mediated influence on NPC cell proliferation and migration. Mechanistically, USP7 deubiquitinated and stabilized TRIM24, which promoted SPLUNC1 expression via recruitment of STAT3 in M1 macrophages. Depletion of TRIM24 inhibited M1 macrophage polarization, which facilitated NPC cell growth and migration. However, over-expression of USP7 exhibited the opposite results and counteracted the tumorigenic effect of TRIM24 silencing. Finally, the growth and metastasis of NPC cells in vivo were repressed by USP7-induced M1 macrophage polarization via modulating TRIM24/SPLUNC1 axis. USP7 delayed NPC progression via promoting macrophage polarization toward M1 through regulating TRIM24/SPLUNC1 pathway, providing evidence for the development of effective antitumor immunotherapies for NPC.
RNF115/BCA2 deficiency alleviated acute liver injury in mice by promoting autophagy and inhibiting inflammatory response
Authors: Feng Jinqiu , Ye Shufang , Hai Bao , Lou Yaxin , Duan Mengyuan , Guo Pengli , Lv Ping , Lu Wenping , Chen Yingyu 
Published: December 2023

AbstractThe E3 ubiquitin ligase RING finger protein 115 (RNF115), also known as breast cancer-associated gene 2 (BCA2), has been linked with the growth of some cancers and immune regulation, which is negatively correlated with prognosis. Here, it is demonstrated that the RNF115 deletion can protect mice from acute liver injury (ALI) induced by the treatment of lipopolysaccharide (LPS)/D-galactosamine (D-GalN), as evidenced by decreased levels of alanine aminotransaminase, aspartate transaminase, inflammatory cytokines (e.g., tumor necrosis factor α and interleukin-6), chemokines (e.g., MCP1/CCL2) and inflammatory cell (e.g., monocytes and neutrophils) infiltration. Moreover, it was found that the autophagy activity in Rnf115−/− livers was increased, which resulted in the removal of damaged mitochondria and hepatocyte apoptosis. However, the administration of adeno-associated virus Rnf115 or autophagy inhibitor 3-MA impaired autophagy and aggravated liver injury in Rnf115−/− mice with ALI. Further experiments proved that RNF115 interacts with LC3B, downregulates LC3B protein levels and cell autophagy. Additionally, Rnf115 deletion inhibited M1 type macrophage activation via NF-κB and Jnk signaling pathways. Elimination of macrophages narrowed the difference in liver damage between Rnf115+/+ and Rnf115−/− mice, indicating that macrophages were linked in the ALI induced by LPS/D-GalN. Collectively, for the first time, we have proved that Rnf115 inactivation ameliorated LPS/D-GalN-induced ALI in mice by promoting autophagy and attenuating inflammatory responses. This study provides new evidence for the involvement of autophagy mechanisms in the protection against acute liver injury.
WWP1 E3 ligase at the crossroads of health and disease
Authors: Behera Abhayananda , Reddy Aramati Bindu Madhava 
Published: December 2023

AbstractThe E3 ubiquitin ligase WWP1 (WW Domain-containing E3 Ubiquitin Protein Ligase 1) is a member of the HECT (Homologous to the E6-associated protein Carboxyl Terminus) E3 ligase family. It is conserved across several species and plays crucial roles in various physiological processes, including development, cell growth and proliferation, apoptosis, and differentiation. It exerts its functions through ubiquitination or protein-protein interaction with PPXY-containing proteins. WWP1 plays a role in several human diseases, including cardiac conditions, neurodevelopmental, age-associated osteogenic disorders, infectious diseases, and cancers. In solid tumors, WWP1 plays a dual role as both an oncogene and a tumor suppressor, whereas in hematological malignancies such as AML, it is identified as a dedicated oncogene. Importantly, WWP1 inhibition using small molecule inhibitors such as Indole-3-Carbinol (I3C) and Bortezomib or siRNAs leads to significant suppression of cancer growth and healing of bone fractures, suggesting that WWP1 might serve as a potential therapeutic target for several diseases. In this review, we discuss the evolutionary perspective, structure, and functions of WWP1 and its multilevel regulation by various regulators. We also examine its emerging roles in cancer progression and its therapeutic potential. Finally, we highlight WWP1’s role in normal physiology, contribution to pathological conditions, and therapeutic potential for cancer and other diseases.
The potential of emerging bio-based products to reduce environmental impacts
Authors: Zuiderveen Emma A. R. , Kuipers Koen J. J. , Caldeira Carla , Hanssen Steef V. , van der Hulst Mitchell K. , de Jonge Melinda M. J. , Vlysidis Anestis , van Zelm Rosalie , Sala Serenella , Huijbregts Mark A. J. 
Published: December 2023

AbstractThe current debate on the sustainability of bio-based products questions the environmental benefits of replacing fossil- by bio-resources. Here, we analyze the environmental trade-offs of 98 emerging bio-based materials compared to their fossil counterparts, reported in 130 studies. Although greenhouse gas life cycle emissions for emerging bio-based products are on average 45% lower (−52 to −37%; 95% confidence interval), we found a large variation between individual bio-based products with none of them reaching net-zero emissions. Grouped in product categories, reductions in greenhouse gas emissions ranged from 19% (−52 to 35%) for bioadhesives to 73% (−84 to −54%) for biorefinery products. In terms of other environmental impacts, we found evidence for an increase in eutrophication (369%; 163 to 737%), indicating that environmental trade-offs should not be overlooked. Our findings imply that the environmental sustainability of bio-based products should be evaluated on an individual product basis and that more radical product developments are required to reach climate-neutral targets.
The Mycobacterium tuberculosis methyltransferase Rv2067c manipulates host epigenetic programming to promote its own survival
Authors: Singh Prakruti R. , Dadireddy Venkatareddy , Udupa Shubha , Kalladi Shashwath Malli , Shee Somnath , Khosla Sanjeev , Rajmani Raju S. , Singh Amit , Ramakumar Suryanarayanarao , Nagaraja Valakunja 
Published: December 2023

AbstractMycobacterium tuberculosis has evolved several mechanisms to counter host defense arsenals for its proliferation. Here we report that M. tuberculosis employs a multi-pronged approach to modify host epigenetic machinery for its survival. It secretes methyltransferase (MTase) Rv2067c into macrophages, trimethylating histone H3K79 in a non-nucleosomal context. Rv2067c downregulates host MTase DOT1L, decreasing DOT1L-mediated nucleosomally added H3K79me3 mark on pro-inflammatory response genes. Consequent inhibition of caspase-8-dependent apoptosis and enhancement of RIPK3-mediated necrosis results in increased pathogenesis. In parallel, Rv2067c enhances the expression of SESTRIN3, NLRC3, and TMTC1, enabling the pathogen to overcome host inflammatory and oxidative responses. We provide the structural basis for differential methylation of H3K79 by Rv2067c and DOT1L. The structures of Rv2067c and DOT1L explain how their action on H3K79 is spatially and temporally separated, enabling Rv2067c to effectively intercept the host epigenetic circuit and downstream signaling.
Revealing hidden patterns in deep neural network feature space continuum via manifold learning
Authors: Islam Md Tauhidul , Zhou Zixia , Ren Hongyi , Khuzani Masoud Badiei , Kapp Daniel , Zou James , Tian Lu , Liao Joseph C. , Xing Lei 
Published: December 2023

AbstractDeep neural networks (DNNs) extract thousands to millions of task-specific features during model training for inference and decision-making. While visualizing these features is critical for comprehending the learning process and improving the performance of the DNNs, existing visualization techniques work only for classification tasks. For regressions, the feature points lie on a high dimensional continuum having an inherently complex shape, making a meaningful visualization of the features intractable. Given that the majority of deep learning applications are regression-oriented, developing a conceptual framework and computational method to reliably visualize the regression features is of great significance. Here, we introduce a manifold discovery and analysis (MDA) method for DNN feature visualization, which involves learning the manifold topology associated with the output and target labels of a DNN. MDA leverages the acquired topological information to preserve the local geometry of the feature space manifold and provides insightful visualizations of the DNN features, highlighting the appropriateness, generalizability, and adversarial robustness of a DNN. The performance and advantages of the MDA approach compared to the existing methods are demonstrated in different deep learning applications.