bluuebunny/crossref_metadata_2025_split huggingface dataset:
In vitro replicative potential of an HIV-1/MO intergroup recombinant virus compared to HIV-1/M and HIV-1/O parental viruses
Authors: Moisan Alice , Tombette Fabienne , Vautrin Manon , Alessandri-Gradt Elodie , Mourez Thomas , Plantier Jean-Christophe 
Published: January 2024

AbstractGenetic recombination is one of the major evolution processes of HIV-1. Despite their great genetic divergence, HIV-1 groups M and O can generate HIV-1/MO intergroup recombinants. The current description of 20 HIV-1/MO unique recombinant forms suggests a possible benefit of the recombination. The aim of this work was to study in vitro the replicative potential of HIV-1/MO recombinant forms. This analysis was based on a simple recombination pattern, [Ogag/pol-Menv], harboring a breakpoint in Vpr. A chimeric infectious molecular clone, pOM-TB-2016 was synthesized from HIV-1/M subtype B and HIV-1/O subgroup T and recombinant viruses were obtained by transfection/co-culture. To compare the replicative potential of these viruses, two markers were monitored in culture supernatants: Reverse Transcriptase (RT) activity and P24 antigen concentration. The results showed a superiority of the group M parental virus compared to group O for both markers. In contrast, for the recombinant virus, RT activity data did not overlap with the concentration of P24 antigen, suggesting a hybrid behavior of the recombinant, in terms of enzyme activity and P24 production. These results highlighted many hypotheses about the impact of recombination on replicative potential and demonstrated again the significant plasticity of HIV genomes and their infinite possibility of evolution.
Fractionation of the Caspian sand goby epidermal exudates using membrane ultrafiltration and reversed-phase chromatography: an investigation on bioactivities
Authors: Akhavan-Bahabadi Mohammad , Paknejad Hamed , Hedayati Aliakbar , Habibi-Rezaei Mehran 
Published: January 2024

AbstractBioactive peptide-based drugs have gained exceeding attention as promising treatments for infectious and oxidative-stress-related diseases, are exacerbated by the advent and spread of various multidrug-resistant bacteria and industrial lifestyles. Fish skin mucus has been recognized as a potential source of bioactive peptides, providing the first line of fish defense against invading pathogens which are targeted here to be explored as a new source of biopharmaceutics. Peptide fractions were isolated from the epidermal exudates of Caspian sand goby, Neogobius fluviatilis pallasi, by solid-phase extraction (SPE), ultrafiltration, and reversed-phase chromatography. The resulting fractions were characterized for their antibacterial and antioxidant properties, and results showed that the molecular weight fraction < 5 kDa represented the highest (p < 0.05) bacterial inhibition activity against Staphylococcus aureus and Bacillus subtilis as well as scavenging activity against DPPH and ABTS radicals. Overall, these results introduce the epidermal mucus of Caspian sand goby as a valuable source of bioactive compounds that can be considered new and efficient biopharmaceutics.
Predicting sustainable fashion consumption intentions and practices
Authors: Hong Yingxiu , Al Mamun Abdullah , Yang Qing , Masukujjaman Mohammad 
Published: January 2024

AbstractThe fashion industry has a significant impact on the environment, and sustainable fashion consumption (SFC) has become a pressing concern. This study aimed to investigate the factors influencing sustainable fashion consumption behavior (SCB) among Chinese adults, specifically the role of values, attitudes, and norms in shaping such behavior, using the value-belief-norm framework. The study used an online cross-sectional survey design to collect data from 350 participants recruited through a convenience sampling method using social media platforms and email invitations, and the obtained data were analyzed using partial least squares structural equation modelling. The results of the study showed that biospheric (BV), altruistic (AV), and egoistic (EV) values significantly influenced the New ecological paradigm (EP), which, in turn, positively affected awareness of consequences (AC). Personal norms (PN) were positively influenced by EP, AC, and ascription of responsibility (AR). Social norms (SN) and trust in recycling (TR) were also found to positively influence sustainable fashion consumption intentions (SCI). Finally, the study found that SCI and TR were significant predictors of SCB, whereas the moderating effect of TR not statistically significant. The study’s originality lies in its comprehensive investigation of the interplay between various factors (particularly using norms in two facets; PN and SN) in shaping SCB, using a structural equation modeling approach, and exploring the moderating effect of TR. The findings of this study suggest that interventions aimed at promoting SFC should focus on fostering values and beliefs that prioritize the environment, encouraging individuals to take responsibility for their actions, creating an environment in which SFC is normalized, and increasing TR.
Prediction of lung cancer using novel biomarkers based on microbiome profiling of bronchoalveolar lavage fluid
Authors: Kim Gihyeon , Park Changho , Yoon Young Kwang , Park Dongil , Lee Jeong Eun , Lee Dahye , Sun Pureum , Park Shinyoung , Yun Changhee , Kang Da Hyun , Chung Chaeuk 
Published: January 2024

AbstractThere is an unmet need for biomarkers for the diagnosis of lung cancer and decision criteria for lung biopsy. We comparatively investigated the lung microbiomes of patients with lung cancer and benign lung diseases. Patients who underwent bronchoscopy at Chungnam National University Hospital between June 2021 and June 2022 were enrolled. Bronchoalveolar lavage fluid (BALF) was collected from 24 patients each with lung cancer and benign lung diseases. The samples were analyzed using 16S rRNA-based metagenomic sequencing. We found that alpha diversity and the beta diversity distribution (P = 0.001) differed significantly between patients with benign lung diseases and those with lung cancer. Firmicutes was the most abundant phylum in patients with lung cancer (33.39% ± 17.439), whereas Bacteroidota was the most abundant phylum in patients with benign lung disease (31.132% ± 22.505), respectively. In differential abundance analysis, the most differentially abundant microbiota taxon was unclassified_SAR202_clade, belonging to the phylum Chloroflexi. The established prediction model distinguished patients with benign lung disease from those with lung cancer with a high accuracy (micro area under the curve [AUC] = 0.98 and macro AUC = 0.99). The BALF microbiome may be a novel biomarker for the detection of lung cancer.
Cardiac output estimation using ballistocardiography: a feasibility study in healthy subjects
Authors: Svensøy Johannes Nordsteien , Alonso Erik , Elola Andoni , Bjørnerheim Reidar , Ræder Johan , Aramendi Elisabete , Wik Lars 
Published: January 2024

AbstractThere is no reliable automated non-invasive solution for monitoring circulation and guiding treatment in prehospital emergency medicine. Cardiac output (CO) monitoring might provide a solution, but CO monitors are not feasible/practical in the prehospital setting. Non-invasive ballistocardiography (BCG) measures heart contractility and tracks CO changes. This study analyzed the feasibility of estimating CO using morphological features extracted from BCG signals. In 20 healthy subjects ECG, carotid/abdominal BCG, and invasive arterial blood pressure based CO were recorded. BCG signals were adaptively processed to isolate the circulatory component from carotid (CCc) and abdominal (CCa) BCG. Then, 66 features were computed on a beat-to-beat basis to characterize amplitude/duration/area/length of the fluctuation in CCc and CCa. Subjects’ data were split into development set (75%) to select the best feature subset with which to build a machine learning model to estimate CO and validation set (25%) to evaluate model’s performance. The model showed a mean absolute error, percentage error and 95% limits of agreement of 0.83 L/min, 30.2% and − 2.18–1.89 L/min respectively in the validation set. BCG showed potential to reliably estimate/track CO. This method is a promising first step towards an automated, non-invasive and reliable CO estimator that may be tested in prehospital emergencies.
Contributions of external forcing and internal variability to the multidecadal warming rate of East Asia in the present and future climate
Authors: Jeong Dajeong , Yoo Changhyun , Yeh Sang-Wook 
Published: January 2024

AbstractExternal forcing and internal variability contribute to multidecadal variation in the warming rate of East Asia. By rescaling the Coupled Model Intercomparison Project Phase 6 multi-model mean to the temperatures observed for the 1890–2020 period, we find that external forcing contributes about −0.2 to 0.1 K decade−1 to the warming rate until the 1980s, but this rate increases to 0.4 K decade−1 in recent decades. This multidecadal variation in the forced response is decomposed further into contributions by greenhouse gases, anthropogenic aerosols, and natural forcing. Once the external component is removed, the warming rate explained by the internal variability is ±0.15 K decade−1 in the twentieth century, reaching about −0.21 K decade−1 in recent decades. We find that 68% of the variance in the internally generated temperature anomaly is explained by the Indian Ocean Basin Mode (IOBM), the Atlantic Multidecadal Oscillation, and the Interdecadal Pacific Oscillation, with the IOBM playing a dominant role. In future Shared Socio-economic Pathway 2-4.5 scenario simulations, the impact of external forcing is projected to triple over the 2020–2100 period. Because the influence of internal variability remains relatively stable over this period, the contribution of external forcing becomes more pronounced in driving East Asian warming. These findings improve our understanding of both external and internal factors that shape trends and variation in the warming rate of East Asia and have implications for constraining future projections.
Differences in regulation mechanisms of glutamine synthetases from methanogenic archaea unveiled by structural investigations
Authors: Müller Marie-Caroline , Lemaire Olivier N. , Kurth Julia M. , Welte Cornelia U. , Wagner Tristan 
Published: January 2024

AbstractGlutamine synthetases (GS) catalyze the ATP-dependent ammonium assimilation, the initial step of nitrogen acquisition that must be under tight control to fit cellular needs. While their catalytic mechanisms and regulations are well-characterized in bacteria and eukaryotes, only limited knowledge exists in archaea. Here, we solved two archaeal GS structures and unveiled unexpected differences in their regulatory mechanisms. GS from Methanothermococcus thermolithotrophicus is inactive in its resting state and switched on by 2-oxoglutarate, a sensor of cellular nitrogen deficiency. The enzyme activation overlays remarkably well with the reported cellular concentration for 2-oxoglutarate. Its binding to an allosteric pocket reconfigures the active site through long-range conformational changes. The homolog from Methermicoccus shengliensis does not harbor the 2-oxoglutarate binding motif and, consequently, is 2-oxoglutarate insensitive. Instead, it is directly feedback-inhibited through glutamine recognition by the catalytic Asp50ʹ-loop, a mechanism common to bacterial homologs, but absent in M. thermolithotrophicus due to residue substitution. Analyses of residue conservation in archaeal GS suggest that both regulations are widespread and not mutually exclusive. While the effectors and their binding sites are surprisingly different, the molecular mechanisms underlying their mode of action on GS activity operate on the same molecular determinants in the active site.
Circular RNA cVIM promotes hepatic stellate cell activation in liver fibrosis via miR-122-5p/miR-9-5p-mediated TGF-β signaling cascade
Authors: Zhou Zhenxu , Zhang Rongrong , Li Xinmiao , Zhang Weizhi , Zhan Yating , Lang Zhichao , Tao Qiqi , Yu Jinglu , Yu Suhui , Yu Zhengping , Zheng Jianjian 
Published: January 2024

AbstractHepatic stellate cell (HSC) activation is considered as a central driver of liver fibrosis and effective suppression of HSC activation contributes to the treatment of liver fibrosis. Circular RNAs (circRNAs) have been reported to be important in tumor progression. However, the contributions of circRNAs in liver fibrosis remain largely unclear. The liver fibrosis-specific circRNA was explored by a circRNA microarray and cVIM (a circRNA derived from exons 4 to 8 of the vimentin gene mmu_circ_32994) was selected as the research object. Further studies revealed that cVIM, mainly expressed in the cytoplasm, may act as a sponge for miR-122-5p and miR-9-5p to enhance expression of type I TGF-β receptor (TGFBR1) and TGFBR2 and promotes activation of the TGF-β/Smad pathway, thereby accelerating the progression of liver fibrosis. Our results demonstrate a vital role for cVIM in promoting liver fibrosis progression and provide a fresh perspective on circRNAs in liver fibrosis.
Outcomes of total hip arthroplasty using dual mobility cups following failed internal fixation of proximal femoral fractures at a mean follow-up of 6 years
Authors: Assi Chahine , Otayek Joeffroy , Mansour Jad , Daher Jimmy , Caton Jacques , Samaha Camille , Yammine Kaissar 
Published: January 2024

Introduction: Performing total hip arthroplasty (THA) after failed internal fixation of proximal femoral fractures (PFF) is known to be associated with high rates of complications. Dual mobility cups (DMC) are known to lower dislocation events in high-risk patients. Very few reports investigated the outcomes of THA using DMC following failure of internal fixation for PFF. Methods: This is a retrospective monocentric continuous study of 31 patients who underwent THA with DMC after failed internal fixation of PFF. The clinical assessment was based on the modified Harris hip score (mHHS) at the last follow-up. The complication rates and radiological analyses were recorded. Results: The mean follow-up period was 5.96 ± 4.2 years. At the last follow-up, the mean mHHS was 92.9 ± 9.1 with 71% of the patients describing their operated hip as a forgotten hip. No dislocation or aseptic loosening events were noted. One patient developed a septic loosening of the implant. No significant radiological changes were recorded. Sixteen stems (51.6%) were placed in a neutral position, 13 (42%) in valgus (2.74 ± 1.72°), and 2 (6.4%) in varus (6.94 ± 2.02°). Conclusion: This study emphasizes the advantage of using DMC following failed internal fixation of PFF in reducing dislocation and complication events in this high-risk population.
Prior medial meniscus arthroscopy is not associated with worst functional outcomes in patients undergoing primary total knee arthroplasty: A retrospective single-center study with a minimum follow-up of 5 years
Authors: Giovanoulis Vasileios , Schmidt Axel , Vasiliadis Angelo V. , Koutserimpas Christos , Batailler Cécile , Lustig Sébastien , Servien Elvire 
Published: January 2024

Introduction: There have been controversial studies on the impact of prior knee arthroscopy (KA) on outcomes of total knee arthroplasty (TKA). The purpose of this comparative study is to investigate the impact of prior KA of medial meniscus on patients undergoing TKA by evaluating the International Knee Society Score (IKS), the complications, and revisions. Methods: This retrospective study reviewed 84 patients with TKA who had undergone prior KA of the medial meniscus and compared them to 84 cases, without a history of prior KA as a control group. Outcomes were assessed with the original IKS scores and complications. The mean follow-up was 8 years. Results: There was no significant difference between groups with respect to demographics, or pre-operative IKS. The mean pre and postoperative IKS was not different between groups. The all-cause reoperation, revision, and complication rates of the KA group were not significantly higher than those of the control group. Conclusion: The present study seems to reveal that previous KA of the medial meniscus does not negatively affect a subsequent TKA. Nevertheless, larger studies may be necessary to confirm this observation.
Cataract Classification Systems: A Review
Authors: Mackenbrock Lars H. B. , Labuz Grzegorz , Baur Isabella D. , Yildirim Timur M. , Auffarth Gerd U. , Khoramnia Ramin 
Published: January 2024

AbstractCataract is among the leading causes of visual impairment worldwide. Innovations in treatment have drastically improved patient outcomes, but to be properly implemented, it is necessary to
have the right diagnostic tools. This review explores the cataract grading systems developed by researchers in recent decades and provides insight into both merits and limitations. To this
day, the gold standard for cataract classification is the Lens Opacity Classification System III. Different cataract features are graded according to standard photographs during slit lamp
examination. Although widely used in research, its clinical application is rare, and it is limited by its subjective nature. Meanwhile, recent advancements in imaging technology, notably
Scheimpflug imaging and optical coherence tomography, have opened the possibility of objective assessment of lens structure. With the use of automatic lens anatomy detection software,
researchers demonstrated a good correlation to functional and surgical metrics such as visual acuity, phacoemulsification energy, and surgical time. The development of deep learning networks
has further increased the capability of these grading systems by improving interpretability and increasing robustness when applied to norm-deviating cases. These classification systems,
which can be used for both screening and preoperative diagnostics, are of value for targeted prospective studies, but still require implementation and validation in everyday clinical
practice.
Retraction Note: Epilepsy and the Quran Recitation as a Meditation
Authors: Çaksen Hüseyin 
Published: January 2024

RetractionAn investigation by the publisher found a number of articles, including this one, published in Journal of Pediatric Epilepsy in Volume 12, Number 02, 63-64, in June 2023 (DOI: 10.1055/s-0042-1756438), with a number of concerns, including but not limited to undeclared conflicts of interest and manipulated peer review procedures. As a result, the publisher has retracted and removed this article.
Retraction Note: A Spiritual View to COVID-19 Pandemic
Authors: Çaksen Hüseyin 
Published: January 2024

RetractionAn investigation by the publisher found a number of articles, including this one, published in Journal of Child Science in Volume 12, Number 01, e170–e171, on November 03, 2022 (DOI: 10.1055/s-0042-1758450), with a number of concerns, including but not limited to undeclared conflicts of interest and manipulated peer review procedures. As a result, the publisher has retracted and removed this article.
Retraction Note: A Spiritual Prescription to Bereaved Parents of Children Died Due to Coronavirus Disease 2019
Authors: Çaksen Hüseyin 
Published: January 2024

RetractionAn investigation by the publisher found a number of articles, including this one, published in Journal of Child Science in Volume 12, Number 01, e117–e118, on September 29, 2022 (DOI: 10.1055/s-0042-1757146), with a number of concerns, including but not limited to undeclared conflicts of interest and manipulated peer review procedures. As a result, the publisher has retracted and removed this article.
Retraction Note: Dogs Bites in Children and a Spiritual View to Dogs
Authors: Çaksen Hüseyin 
Published: January 2024

RetractionAn investigation by the publisher found a number of articles, including this one, published in Journal of Child Science in Volume 12, Number 01, e144–e145, on September 29, 2022 (DOI: 10.1055/s-0042-1757154), with a number of concerns, including but not limited to undeclared conflicts of interest and manipulated peer review procedures. As a result, the publisher has retracted and removed this article.
Retraction Note: Parental Concerns in Children with Febrile Convulsions
Authors: Çaksen Hüseyin 
Published: January 2024

RetractionAn investigation by the publisher found a number of articles, including this one, published in Journal of Pediatric Epilepsy in Volume 11, Number 04, 95-96, in December 2022 (DOI: 10.1055/s-0042-1757159), with a number of concerns, including but not limited to undeclared conflicts of interest and manipulated peer review procedures. As a result, the publisher has retracted and removed this article.
Retraction Note: Visiting the Sick in Hospitalized Children with Neurological Disorders
Authors: Çaksen Hüseyin 
Published: January 2024

RetractionAn investigation by the publisher found a number of articles, including this one, published in Journal of Pediatric Neurology on September 28, 2022 (DOI: 10.1055/s-0042-1756449), with a number of concerns, including but not limited to undeclared conflicts of interest and manipulated peer review procedures. As a result, the publisher has retracted and removed this article.
Retraction Note: Patients' Supernatural Beliefs on Cause of Multiple Sclerosis
Authors: Çaksen Hüseyin 
Published: January 2024

RetractionAn investigation by the publisher found a number of articles, including this one, published in Journal of Pediatric Neurology on April 17, 2023 (DOI: 10.1055/s-0043-57006), with a number of concerns, including but not limited to undeclared conflicts of interest and manipulated peer review procedures. As a result, the publisher has retracted and removed this article.
The specific visuality of women of the global South in the media of the global North
Authors: Lee Sohyun 
Published: January 2024

AbstractThis paper examines how neoliberal, gendered discourses of globalization position marginalized communities of women in popular culture, focusing on the ways in which the media of the global North produces the specific visuality of women of the global South. The representations of women of the global South, such as factory workers, mail/online-order brides, and domestic workers, point to the globalized mode of feminization of labor and the power asymmetry inherent in globalization. By analyzing the ways in which the female body of the global South embodies commodification, sexualization, and abjection, the paper points out that women’s experiences are marginalized or erased in the neoliberal narrative of globalization. The (re)imagination of women of the global South in the media of the global North testifies to the historical legacy and discursive traditions of the colonial/imperial past and points to the reproduction and dissemination of sexualized and racialized imagery of otherness.
Pain in Sheep
Authors: McLennan Krista M. 
Published: January 2024

Abstract
Pain in sheep can occur for a variety of reasons, including disease, injury, and naturally through parturition. Sheep, as a prey species, do not overtly express pain making it challenging for owners and veterinarians to recognise and thus effectively treat pain. By observing facial expressions, it is possible to recognise and quantify the pain a sheep may be experiencing. This enables the provision of treatment and the prevention of any further suffering.

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