bluuebunny/crossref_metadata_2025_split huggingface dataset:
The Association Between Hearing Loss and Depression in a Large Electronic Health Record System
Authors: Weinstein Hannah N.W. , Tucker Lauren H. , Grewal Maeher R. , Denham Michael W. , Brewster Katharine K. , Golub Justin S. 
Published: January 2025

AbstractObjectiveHearing loss (HL) is associated with depression, but existing datasets are limited by the type of data available for both hearing and mental health conditions. The purpose of this study is to determine if there is an association between HL and depressive disorders within a large bi‐institutional electronic health record (EHR) system containing more granular diagnostic information.Study DesignCross‐sectional epidemiologic study.SettingTwo academic medical centers.MethodsAudiometric data was collected from patients ≥18 years old between 2020 to mid‐2023 (n = 29,772). The exposure was HL defined as the 4‐frequency pure‐tone average (PTA), speech reception threshold (SRT), and word recognition score (WRS). The outcomes were depression, categorized as either: (1) major depressive disorder, defined by International Classification of Diseases, 10th Revision (ICD‐10) code; (2) persistent mood disorder, defined by ICD‐10 code; or (3) antidepressant medication use, defined by medication lists. Odds ratios were computed from logistic regressions between HL and each of the outcome variables, controlling for age, sex, cardiovascular risks, and site.ResultsThe mean age (standard deviation) was 60.5 (18.2) years, and 17,736 participants (59.6%) were female. Controlling for covariates, for every 10‐dB worsening in hearing by PTA, the odds of major depressive disorder increased by 1.04 times (95% confidence interval [CI] = 1.01‐1.07, P = .015). Similarly, for every 10 dB worsening in hearing by PTA or SRT, the odds of antidepressant medication use increased by 1.04 times (95% CI = 1.01‐1.06, P = .004). Odds ratios for persistent mood disorder were nonsignificant.ConclusionIn a large academic EHR, HL is associated with major depressive disorder and antidepressant medication use.
Effect of Histamine‐2 Receptor Antagonists on Hypocalcemia after Thyroidectomy: A Retrospective Cohort Study and Sensitivity Analysis
Authors: Rossip Maxwell , Lorenz F Jeffrey , Sciscent Bao , Truong Nguyen , Nimmagadda Chaitanya , Goyal Neerav , Goldenberg David 
Published: January 2025

AbstractObjectiveThe objective of this study is to examine the risk of hypocalcemia after thyroidectomy in patients taking histamine‐2 receptor antagonists.Study DesignRetrospective cohort study.SettingMulticenter, single database.MethodsThirty‐four thousand two hundred eighteen patients treated with total thyroidectomy from 2011 to 2022 were identified via the TriNetX Research Network. We compared the incidence of transient (0‐1 month and 1‐6 months following thyroidectomy) and permanent (6‐12 months following thyroidectomy) postthyroidectomy hypocalcemia in patients with and without H2 receptor antagonists. Propensity score matching and sensitivity analysis were done to control for additional risk factors.ResultsPatients were divided into 2 cohorts: those with an H2 receptor antagonist prescription before surgery (n = 5108) and those without (n = 29,110). 44.9% and 11.6% of thyroidectomy patients taking H2 receptor antagonists had hypocalcemia compared to 38.3% and 8.2% of patients without H2 receptor antagonists at 0 to 1 month and 6 to 12 months, respectively. Patients taking H2 receptor antagonists had a significantly increased risk of experiencing hypocalcemia at 0 to 1 month, 1 to 6 months, and 6 to 12 months. Patients taking H2 receptor antagonists were also at increased risk for visiting the emergency department and receiving intravenous calcium replenishment at 1 and 6 months following surgery. Sensitivity analysis continued to yield significant results at all time points.ConclusionPatients taking H2 receptor antagonists may be at increased risk of short and long‐term hypocalcemia after thyroid surgery. This is the first retrospective cohort study examining the risk of hypocalcemia after thyroidectomy in patients taking H2 receptor antagonists.
A Perspective on Women in Otolaryngology Through the Legacy of Dr. Margaret F. Butler
Authors: Tong Jane Y. 
Published: January 2025

AbstractThis article explores the life of Dr. Margaret F. Butler and her many contributions to the field of otolaryngology. Dr. Butler not only served as the first female chair of an otolaryngology department at the Woman's Medical College of Pennsylvania but her mentorship of other physicians also helped support early efforts to promote gender diversity in the specialty of otolaryngology. Using autobiographical material including Dr. Butler's writings and speeches, many housed in The Legacy Center Archives and Special Collections at Drexel University College of Medicine, we explore the legacy of Margaret F. Butler to provide a perspective on women in otolaryngology.
Lipopolysaccharide Causes Acquired CFTR Dysfunction in Murine Nasal Airways
Authors: Grayson Jessica W. , Norwood T. Graham , Zhang Shaoyan , Skinner Daniel , Cho Do‐Yeon , Woodworth Bradford A. 
Published: January 2025

AbstractObjectiveCystic fibrosis (CF) is a clinical entity defined by aberrant chloride (Cl−) ion transport causing downstream effects on mucociliary clearance (MCC) in sinonasal epithelia. Inducible deficiencies in transepithelial Cl− transport via CF transmembrane conductance regulator (CFTR) has been theorized to be a driving process in recalcitrant chronic rhinosinusitis (CRS) in patients without CF. We have previously identified that brief exposures to bacterial lipopolysaccharide (LPS) in mammalian cells induces an acquired dysfunction of CFTR in vitro and in vivo. The objective of the current study is to evaluate whether LPS generates a model of acquired CFTR dysfunction murine nasal airways.Study DesignBasic science.SettingLaboratory.MethodsCFTR+/+ murine nasal airways were irrigated with 2 µg/mL LPS or control vehicle twice daily for 1 week and transepithelial Cl− transport assessed with the nasal potential difference (NPD) assay. Histopathologic evaluation included the number of lymphoid aggregates, as well as the epithelial and subepithelial heights.ResultsTransepithelial Cl− secretion by NPD was markedly reduced in mice exposed to LPS (in mV, −0.14 ± 7.7 vs control, −6.98 ± 7.15, P < .05), while amiloride‐sensitive voltage was preserved (6.38 ± 5.09 vs control, 7.36 ± 2.87, P = .99). Histopathology demonstrated significantly higher lymphoid aggregates per high‐power field (2.3 ± 0.9 vs 1.1 ± 0.7, control, P < .01) and increased epithelial height (in µm, 40.88 ± 13.9 vs control, 25.32 ± 6.26, P < .05).ConclusionTwice daily irrigation with LPS in murine nasal airways over 1 week led to acquired defects in transepithelial Cl− transport. This animal model provides an excellent means to test the contributions of acquired CFTR dysfunction to CRS and test CFTR correctors and potentiators that might improve MCC.
Financial Impact of Medicare Payment Reform for E/M Visits on Compensation for Otolaryngologic Procedures in 2023
Authors: Miller Lauren E. , Miller Ashley L. , Rocco James W. , Rathi Vinay K. 
Published: January 2025

ABSTRACTThe Centers for Medicare & Medicaid Services (CMS) recently increased payment for evaluation and management (E/M) visits, but did not apply these updates to post‐operative global period visits. We investigated the resulting Medicare fee‐for‐service revenue loss for otolaryngologists. Using publicly available Medicare spending/utilization data, we estimated how much additional payment otolaryngologists would have received in 2023 if CMS had reimbursed global period visits at the same rates as other E/M visits. Our analysis included 291 procedures with 10‐ or 90‐day global periods. The total estimated global period revenue loss was $7.0 M and concentrated among facial plastic/reconstructive ($3.3 M; 47.1%), head and neck ($1.5 M; 21.4%), and otologic ($1.2 M; 17.1%) procedures. Total estimated losses were greatest for nasal septoplasty (CPT 30520; $1.2 M), tympanostomy with ventilating tube placement (CPT 69433; $0.6 M), and cervical lymphadenectomy (CPT 38724; $0.5 M). Payment reforms based on robust and empirically‐derived measures of physician work are necessary to promote fair procedural compensation.
Clinical Efficacy and Outcomes of Electro‐Pneumatic Intracorporeal Lithotripsy in the Management of Sialolithiasis
Authors: Filipov Iulian , Chirila Lucian , Sandulescu Mihai , Cristache Gheorghe , Cristache Corina Marilena 
Published: January 2025

AbstractObjectiveThis study aims to evaluate the clinical efficacy of electro‐pneumatic intracorporeal lithotripsy for the treatment of salivary gland stones.Study DesignA prospective cohort study of patients diagnosed with obstructive salivary gland syndrome, where basket‐assisted sialendoscopy alone failed to remove the calculi.SettingThis study was conducted at the “Queen Maria” Military Hospital in Brașov, Romania, and a private practice, between February 2023 and May 2024.MethodsA total of 29 patients with salivary calculi were treated using the SialoLither device (Hidromed), which operates on the electro‐pneumatic principle. The number of sessions required for complete stone removal, the duration of each session, and the number of ballistic impulses applied were recorded. Statistical analyses, including the Mann‐Whitney U test and multiple linear regression, were conducted to assess the relationship between stone size, location, and treatment outcomes.ResultsComplete removal was achieved in 72.4% of patients after a single session, with 100% success after 3 sessions. The average number of impulses was 13.9 (±4.25), with no significant difference in outcomes between the parotid and submandibular glands (P > .05). The total duration varied, with a mean time of 89.97 (±54.89) minutes. Complications were minimal, with only 2 cases of minor epithelial damage.ConclusionElectro‐pneumatic intracorporeal lithotripsy is a highly effective, minimally invasive technique for managing salivary calculi, offering a safe and efficient alternative to traditional surgical methods.
Spina bifida as a multifactorial birth defect: Risk factors and genetic underpinnings
Authors: Wong Ethan S. , Hu Daniel A. , Zhang Lily , Qi Rachel , Xu Cindy , Mei Ou , Shen Guowei , You Wulin , Luo Changqi , He Tong‐Chuan , Reid Russell R. , Shi Lewis S. , Lee Michael J. , Zhu Yi 
Published: January 2025

AbstractSpina bifida is a birth defect resulting from abnormal embryonic development of the neural tube. Though spina bifida is divided into several subtypes, myelomeningocele—the most severe form of spina bifida often associated with a markedly diminished quality of life—accounts for a significant portion of cases. A broad range of genetic and environmental factors, many of which are still unknown, influence spina bifida, making it difficult to provide a comprehensive etiology for the disorder. Folic acid supplementation aided by the mandatory fortification of food is preventive; still, spina bifida persists due to numerous other confounding factors that affect risk. This article reviews the latest studies pertaining to the risk factors and genetics involved in spina bifida in an attempt to elucidate the complex background of the congenital malformation. Additionally, this review highlights the significant impact of environmental pollutants, adverse medication effects, and maternal health conditions such as diabetes and obesity on the prevalence of spina bifida. Emerging research on gene‐environment interactions provides insight into how specific genetic variants may influence susceptibility to these environmental factors. We also discuss new technologies in genetic sequencing that show promise for the large‐scale discovery of genes associated with spina bifida risk. Understanding these intricate interactions is crucial for developing effective prevention and intervention strategies.
What Do Students Feel, and What Do Teachers Say?: A Mixed‐Methods Study
Authors: Calik Basak , Capa‐Aydin Yesim 
Published: January 2025

ABSTRACTThe current study aims to investigate the interplay between teacher and student emotions in mathematics and the triggers of student emotions from the perspectives of their mathematics teachers. Mixed‐methods research was employed. In the quantitative phase, 214 middle school mathematics teachers and their seventh and eighth graders (5475 students total) participated in the study to explore the relationship between teacher and student emotions in mathematics. Afterward, 14 mathematics teachers were selected to participate in the qualitative phase according to the variation in class mean values of the student achievement emotion scale. Data were collected through questionnaires (Achievement Emotions Questionnaire‐Mathematics, Teacher Emotions Scale) and semi‐structured interviews. Multilevel structural equation modeling revealed no significant correlation between teacher enjoyment, anger, anxiety, and student emotions. Thematic analysis unraveled four themes in explaining the factors affecting students' emotions in mathematics: types of emotions in mathematics learning, sources of emotions, consequences of emotions, and strategies to regulate students' emotions in mathematics. This study stands as the pioneering one in emotional transmission between teachers and students in Turkiye.
Relationships Between Dimensions of Perfectionism and Perceived Test Threat
Authors: Ahmadi Tina , Finch W. Holmes , Helsper C. Addison , Cassady Jerrell 
Published: January 2025

ABSTRACTPerfectionism research has progressively supported an identification of two related dimensions, referred to as perfectionistic strivings (PS) and perfectionistic concerns (PC). Examinations of learner experiences based on these two dimensions have routinely demonstrated differential influence on academic emotions and performances, examining the constructs from either dimensional or typological approaches. The aim of this study was to determine the relationships among each dimension of perfectionism with cognitive test anxiety (CTA), self‐regulated learning strategies (SRL), and learners' threat appraisals related to forthcoming tests (Perceived Test Threat or PTT). Structural equation modeling revealed that (a) CTA partially mediated the relationship between PC and PTT and (b) SRL fully mediated the inverse relationship between PS and PTT. Furthermore, generalized additive model (GAM) confirmed a positive linear relationship between PC and PTT, but revealed the relationship between PS and PTT was curvilinear. The results indicate that moderate levels of PS support more positive appraisals of academic outcomes by activating self‐regulated learning tendencies. Conversely, as learners' levels of PC increased, so did their activation of test anxiety and a subsequent appraisal of tests as threatening events.
Middle School Students' Motivations and Learning Competencies in Science: Mediating Role of Digital Literacy
Authors: Nacaroğlu Oğuzhan , Kızkapan Oktay , Demir Hüseyin 
Published: January 2025

ABSTRACTScience learning motivation refers to the drive and enthusiasm that students exhibit towards learning science. Science learning competencies, on the other hand, are the skills and knowledge enabling students to understand and apply scientific concepts effectively. Digital literacy, defined as the ability to effectively use digital tools and resources, has emerged as a crucial skill in modern education. Digital literacy can bridge the gap between motivation and competencies by providing students with the tools they need to engage more deeply with scientific content. Given its significance, exploring the mediating role of digital literacy in the relationship between science learning motivation and competence is essential. Hence, we aimed to test the mediating role of digital literacy in the relationship between middle school students' science learning motivation and science learning competencies. To test these relations, we adopted the correlation design of the quantitative research method. The sample consisted of 471 middle school students. Science learning motivation scale, competence scale for learning science, and digital literacy scale were used to collect data. The hypothesis model was tested by using covariance‐based structural equation modeling (CB‐SEM). The results showed that science learning motivation is correlated with students' science learning competency (r = 0.891, p < 0.05) and digital literacy (r = 0.538, p < 0.05). Also, digital literacy partially mediates the relation between science learning motivation and science learning competency (r = 0.757, p < 0.05). These findings highlight the importance of fostering digital literacy in educational settings to enhance students' motivation and competency in science learning. Educators and policymakers should integrate digital tools and resources into the curriculum to create a more engaging and effective learning environment, thereby bridging the gap between students' motivation and their ability to master scientific concepts.
Meaning in Life as an Outcome of Inpatient or Day‐Hospital Psychotherapy for Personality Disorder
Authors: Steen Angelien , Braam Arjan W. , Hoogendoorn Adriaan W. , Berghuis Han , Glas Gerrit 
Published: January 2025

ABSTRACTPsychotherapy may contribute to the experience of meaning in life. This study investigated meaning in life among patients with personality disorders during inpatient or day‐hospital psychotherapy. Meaning in life was approached from two conceptual perspectives: personality functioning with an emphasis on self‐direction and existential psychology. We investigated changes in the sense of meaning in life and accounted for changes in depressive symptoms and identity and interpersonal pathology. Using pre–post measures, Livesley's General Assessment of Personality Disorder, especially, the Lack‐of‐Meaning‐Purpose‐and‐Direction subscale and Steger's Meaning‐in‐Life Presence subscale were administered to 75 patients with personality disorders during inpatient or day‐hospital psychotherapy for 8–12 months. Regression models showed that levels of the lack and presence of meaning decreased and increased during treatment, respectively, controlled for changes in depressive symptoms. Decreased identity pathology was significantly associated with changes in the lack or presence of meaning. Meaning in life may act as an outcome variable in intensive psychotherapy for personality disorders. The development of identity and self‐direction may restore or create the ability to give life meaning.
Charged Gravastar Solutions in the Finch‐Skea Framework with f(Q)$f(\mathbb {Q})$ Gravity
Authors: Sharif Muhammad , Ajmal Madiha 
Published: January 2025

AbstractIn this study, the features of a charged gravastar are investigated within the framework of gravity ( represents nonmetricity) using the Finch–Skea metric. This metric is applied to both the interior and shell regions of the charged gravastar and the field equations are derived accordingly. For the exterior regions, various black holes are considered, i.e., Reissner–Nordström, Bardeen, and Hayward regular black holes. The interior and exterior layers are matched using the Israel junction conditions, which help to determine the surface energy density and surface pressure for these black holes. Some physical properties such as proper length, entropy, energy, and the equation of state parameter are examined. The stability of the developed gravastar model is discussed through the effective potential, the causality condition and adiabatic index. It is concluded that the compact gravastar structure could be a viable alternative to black holes within this framework.
Determination of 115 Pesticide Residues in Textiles by Liquid Chromatography–Tandem Mass Spectrometry
Authors: Li Ying , Ye Xiwen , Luo Xin , Zhu Wenxuan , Tang Zhixu , Niu Zengyuan 
Published: January 2025

ABSTRACTThe presence of pesticide residues in textiles poses a risk to human health. We established a robust and high‐throughput liquid chromatography–tandem mass spectrometry method for the determination of 115 pesticide residues in textiles. In this study, we evaluated high‐performance liquid chromatography–tandem mass spectrometry conditions and sample extraction methods, including separation performance of different columns, mass conditions, extraction solvent, and extraction time. Finally, we established the method as follows: After ultrasonic extraction with methanol, we blew the sample with nitrogen to dry and then took it to a fixed volume by a specific solvent. We used a C18 reversed‐phase chromatographic column and detected the samples in the multiple reaction monitoring mass mode. And we verify the limit of detection (LOD), limit of quantitation (LOQ), linearity, recovery, and precision. The LOD and LOQ of the method was 10 and 20 μg/kg separately; the recoveries ranged from 71.3% to 118.4%; and the relative standard deviation was 0.2%–19.9%. We verified the applicability of the developed protocol through the analysis of 21 real textile products.
A Review of Research on Engineering in K‐12 Science Education
Authors: Antink‐Meyer Allison , Brown Ryan A. , Parker Margaret E. , Smith Jennifer 
Published: January 2025

ABSTRACTThe purpose of this study is to explore trends in interrelated engineering education and science education research within six science education research journals across the first decade since the release of the Framework for K‐12 Science Education and the Next Generation Science Standards. Journals were selected using a combination of impact factors and random sampling. The resulting qualitative systematic review exposes trends that arose and fell among science education journals and scholars as reflected in 141 articles published between 2011 and 2024 in the Journal of Research in Science Teaching, Science Education, the International Journal of Science Education, School Science and Mathematics, the Journal of Science Teacher Education and Cultural Studies of Science Education. Through the analysis of 289 published research questions and purposes, themes of research and stakeholder foci were developed to uncover trends in research across this timespan. The greatest proportion of research examined student learning of science content through engineering experiences and teacher practice concerning science and engineering adjacent learning. Gaps in the literature are also described including studies in greater need of focus, most notably those that examine the roles of communities, families, learner agency, and access to engineering and science. Findings illuminate a need for improved resonance between the calls of policy for advancing access to science, STEM, and engineering education and literacies and research that remains most focused on traditional settings and structures.