bluuebunny/crossref_metadata_2025_split huggingface dataset:
Daily dose–response from short‐term monocular deprivation in adult humans
Authors: Zou Liying , Zhou Chenyan , Hess Robert F. , Zhou Jiawei , Min Seung Hyun 
Published: February 2024

AbstractShort‐term monocular deprivation (MD) shifts sensory eye balance in favour of the previously deprived eye. The effect of MD on eye balance is significant but brief in adult humans. Recently, researchers and clinicians have attempted to implement MD in clinical settings for adults with impaired binocular vision. Although the effect of MD has been studied in detail in single‐session protocols, what is not known is whether the effect of MD on eye balance deteriorates after repeated periods of MD (termed ‘perceptual deterioration’). An answer to this question is relevant for two reasons. Firstly, the effect of MD (i.e., dose‐response) should not decrease with repeated use if MD is to be used therapeutically (e.g., daily for weeks). Second, it bears upon the question of whether the neural basis of the effects of MD and contrast adaptation, a closely related phenomenon, is the same. The sensory change from contrast adaptation depends on recent experience. If the observer has recently experienced the same adaptation multiple times for consecutive days, then the adaptation effect will be smaller because contrast adaptation exhibits perceptual deterioration, so it is of interest to know if the effects of MD follow suit. This study measured the effect of 2‐h MD for seven consecutive days on binocular balance of 15 normally sighted adults. We found that the shift in eye balance from MD stayed consistent, showing no signs of deterioration after subjects experienced multiple periods of MD. This finding shows no loss of effectiveness of repeated daily doses of MD if used therapeutically to rebalance binocular vision in otherwise normal individuals. Furthermore, ocular dominance plasticity, which is the basis of the effects of short‐term MD, does not seem to share the property of ‘perceptual deterioration’ with contrast adaptation, suggesting different neural bases for these two related phenomena.
Biomechanical Comparison of Anterior Cervical Corpectomy Decompression and Fusion, Anterior Cervical Discectomy and Fusion, and Anterior Controllable Antedisplacement and Fusion in the Surgical Treatment of Multilevel Cervical Spondylotic Myelopathy: A Finite Element Analysis
Authors: Kong Qingjie , Li Fudong , Yan Chen , Sun Jingchuan , Sun Peidong , Ou‐Yang Jun , Zhong Shizhen , Wang Yuan , Shi Jiangang 
Published: February 2024

PurposeMultilevel cervical spondylotic myelopathy poses significant challenges in selecting optimal surgical approaches, warranting a comprehensive understanding of their biomechanical impacts. Given the lack of consensus regarding the most effective technique, this study aims to fill this critical knowledge gap by rigorously assessing and comparing the biomechanical properties of three distinct surgical interventions, including anterior controllable antedisplacement and fusion (ACAF), anterior cervical corpectomy decompression and fusion (ACCF), and anterior cervical discectomy and fusion (ACDF). The study offers pivotal insights to enhance treatment precision and patient outcomes.MethodsThe construction of the cervical spine model involved a detailed process using CT data, specialized software (Mimics, Geomagic Studio, and Hypermesh) and material properties obtained from prior studies. Surgical instruments were modeled (titanium mesh, anterior cervical plate, interbody cage, and self‐tapping screws) to simulate three surgical approaches: ACAF, ACCF, and ACDF, each with specific procedures replicating clinical protocols. A 75‐N follower load with 2 Nm was applied to simulate biomechanical effects.ResultsThe range of motion decreased more after surgery for ACAF and ACDF than for ACCF, especially in flexion and lateral bending. ACCF have higher stress peaks in the fixation system than those of ACAF and ACDF, especially in flexion. The maximum von Mises stresses of the bone–screw interfaces at C3 of ACCF were higher than those of ACAF and ACDF. The maximum von Mises stresses of the bone–screw interfaces at C6 of ACDF were much higher than those of ACAF and ACCF. The maximum von Mises stresses of the grafts of ACCF and ACAF were much higher than those of ACDF. The maximum von Mises stresses of the endplate of ACCF were much higher than those of ACAF and ACDF.ConclusionThe ACAF and ACDF models demonstrated superior cervical reconstruction stability over the ACCF model. ACAF exhibited lower risks of internal fixation failure and cage subsidence compared to ACCF, making it a promising approach. However, while ACAF revealed improved stability over ACCF, higher rates of subsidence and internal fixation failure persisted compared to ACDF, suggesting the need for further exploration of ACAF's long‐term efficacy and potential improvements in clinical outcomes.
A case of atrial tachycardia originating from the left atrial roof successfully ablated via the pulmonary artery approach
Authors: Liu Wenwu , Zhang Qitong , Wu Xiaoyu , Gao Longzhe , Wei Yong , Liu Shaowen , Zhou Genqing 
Published: February 2024

AbstractA 60‐year‐old male patient suffered from frequent episodes of atrial tachycardia (AT), after the index procedure of catheter ablation for paroxysmal atrial fibrillation. During the repeat procedure, the activation map showed that the earliest activation site was located at the roof of left atrium. Multiple ablations at the earliest activation site on the roof failed to terminate the AT; however, ablation within the pulmonary artery at an adjacent anatomical site successfully eliminated the AT, even without recording distinct near‐field potential.
Chronic phase subcutaneous implantable cardioverter defibrillator lead dislodgement in a patient with arrhythmogenic right ventricular cardiomyopathy
Authors: Chatani Ryuki , Tasaka Hiroshi , Sakata Atsushi , Yoshino Mitsuru , Kadota Kazushige 
Published: February 2024

AbstractThe subcutaneous implantable cardioverter defibrillator (S‐ICD) is often used in young patients such as arrhythmogenic right ventricular cardiomyopathy (ARVC) and Brugada syndrome due to long‐term lead durability issues. Although S‐ICD lead dislodgement is rare, we encountered such an incident in a young ARVC patient during the chronic phase following the two‐incision technique. Remote monitoring system is useful for early diagnosis of electrode movement (Graphical abstract image). When S‐ICD lead dislodgement occurs in active young patients, lead revision using the three‐incision technique may be an option.
Road Access, Fertility, and Child Health in Rural India
Authors: Dasgupta Aparajita , Karandikar Anahita , Raghav Devvrat 
Published: February 2024

AbstractExpansion in access to public infrastructure can have varied, microlevel impacts. In this paper, we use a discrete and quasi‐random change in the access to paved roads through a large‐scale rural road construction program in India to study how road access impacts fertility decisions and investments in child health. We find that increased access to paved roads at the district level decreases fertility, improves investments in children, and lowers infant mortality. We also provide evidence that highlights the mechanisms that drive this effect. First, we show that local roads improve access to health care facilities and raise immunization rates, which reduces infant mortality. Then, we demonstrate that last‐mile road connectivity has contrasting effects on employment across gender. Overall, the evidence suggests that rural roads can help accelerate demographic transition through their effects on fertility and infant mortality.
Strategies for tobacco‐free survivorship after breast cancer: The possible weaving of preoperative care and public health policies
Authors: Maselli Deborah 
Published: February 2024

AbstractAmong smoker women with breast cancer quitting smoking has been shown to increase survival and surgical outcomes. Where surgery is indicated, the preoperative seems to be a crucial moment for smoking cessation interventions as it enhances recovery after surgery and motivates prolonged tobacco abstinence. Timing and frequency of preoperative quitting conversations were variables associated with quitting. An early, multidisciplinary, and personalized approach is recommended. A solid integration between primary care services and specialized care is challenging but feasible, implementing prehabilitation pathways that include tobacco treatment routinely as an integral part of breast cancer care. Smoking cessation programs before surgical procedures impact recidivism prevention, survivorship improvement, public health, and cost savings. The contribution of healthcare professionals can make a difference in tobacco control, collaborating with organizations, public health, and nursing research. Integrated solutions in oncological clinical care pathways might help patients build and maintain tobacco abstinence after breast cancer. Future research shall study when patients should abstain from smoking before oncological breast surgery.
Interactions of drosophila cryptochrome
Authors: Ozcelik Gozde , Koca Mehmet Serdar , Sunbul Buket , Yilmaz‐Atay Fatma , Demirhan Feride , Tiryaki Busra , Cilenk Kevser , Selvi Saba , Ozturk Nuri 
Published: February 2024

AbstractIn this study, we investigate the intricate regulatory mechanisms underlying the circadian clock in Drosophila, focusing on the light‐induced conformational changes in the cryptochrome (DmCry). Upon light exposure, DmCry undergoes conformational changes that prompt its binding to Timeless and Jetlag proteins, initiating a cascade crucial for the starting of a new circadian cycle. DmCry is subsequently degraded, contributing to the desensitization of the resetting mechanism. The transient and short‐lived nature of DmCry protein–protein interactions (PPIs), leading to DmCry degradation within an hour of light exposure, presents a challenge for comprehensive exploration. To address this, we employed proximity‐dependent biotinylation techniques, combining engineered BioID (TurboID) and APEX (APEX2) enzymes with mass spectrometry. This approach enabled the identification of the in vitro DmCry interactome in Drosophila S2 cells, uncovering several novel PPIs associated with DmCry. Validation of these interactions through a novel co‐immunoprecipitation technique enhances the reliability of our findings. Importantly, our study suggests the potential of this method to reveal additional circadian clock‐ or magnetic field‐dependent PPIs involving DmCry. This exploration of the DmCry interactome not only advances our understanding of circadian clock regulation but also establishes a versatile framework for future investigations into light‐ and time‐dependent protein interactions in Drosophila.
A novel type of neighbour perception elicits reproductive plasticity in an annual plant with a mixed mating system
Authors: Falik O. , Hoffmann I. , Novoplansky A. 
Published: February 2024

Abstract
Plants display various forms of phenotypic plasticity in anticipation of changing conditions, many of which are influenced by information obtained from neighbouring plants. Here, we tested the hypothesis that cleistogamic Lamium amplexicaule plants can adaptively modify production of chasmogamous (CH) and cleistogamous (CL) flowers based on the perception of conspecific neighbours.
The production and proportion of CH and CL flowers was examined in individual L. amplexicaule grown at varying densities or treated with root leachates from plants grown at different densities.
When growing at high density or treated with root leachates from high‐density pots, L. amplexicaule increased production of more expensive, potentially outcrossing CH flowers. In contrast, single plants or plants treated with root leachates from empty pots or single‐source plants predominantly developed cheaper, self‐pollinated CL flowers.
The results demonstrate a novel root‐based neighbour‐perception modality that enables plants to adaptively adjust production of CH and CL flowers in response to the presence of potential reproductive partners. Further research is needed to explore the broader ecological implications of this novel interplant cueing on reproductive bet‐hedging and plasticity in natural settings, as well as to identify the involved cues and their mode of operation.
The development of non‐resorbable bone allografts: Biological background and clinical perspectives
Authors: Miron Richard J. , Fujioka‐Kobayashi Masako , Pikos Michael A. , Nakamura Toshiaki , Imafuji Takatomo , Zhang Yufeng , Shinohara Yukiya , Sculean Anton , Shirakata Yoshinori 
Published: February 2024

AbstractBone grafts are typically categorized into four categories: autografts, allografts, xenografts, and synthetic alloplasts. While it was originally thought that all bone grafts should be slowly resorbed and replaced with native bone over time, accumulating evidence has in fact suggested that the use of nonresorbable xenografts is favored for certain clinical indications. Thus, many clinicians take advantage of the nonresorbable properties/features of xenografts for various clinical indications, such as contour augmentation, sinus grafting, and guided bone regeneration, which are often combined with allografts (e.g., human freeze‐dried bone allografts [FDBAs] and human demineralized freeze‐dried bone allografts [DFDBAs]). Thus, many clinicians have advocated different 50/50 or 70/30 ratios of allograft/xenograft combination approaches for various grafting procedures. Interestingly, many clinicians believe that one of the main reasons for the nonresorbability or low substitution rates of xenografts has to do with their foreign animal origin. Recent research has indicated that the sintering technique and heating conducted during their processing changes the dissolution rate of hydroxyapatite, leading to a state in which osteoclasts are no longer able to resorb (dissolve) the sintered bone. While many clinicians often combine nonresorbable xenografts with the bone‐inducing properties of allografts for a variety of bone augmentation procedures, clinicians are forced to use two separate products owing to their origins (the FDA/CE does not allow the mixture of allografts with xenografts within the same dish/bottle). This has led to significant progress in understanding the dissolution rates of xenografts at various sintering temperature changes, which has since led to the breakthrough development of nonresorbable bone allografts sintered at similar temperatures to nonresorbable xenografts. The advantage of the nonresorbable bone allograft is that they can now be combined with standard allografts to create a single mixture combining the advantages of both allografts and xenografts while allowing the purchase and use of a single product. This review article presents the concept with evidence derived from a 52‐week monkey study that demonstrated little to no resorption along with in vitro data supporting this novel technology as a “next‐generation” biomaterial with optimized bone grafting material properties.
The policy feedback effects of preemption
Authors: SoRelle Mallory E. , Fullerton Allegra H. 
Published: February 2024

AbstractScholars have charted a dramatic rise in the use of preemption both at the federal and state levels since the 1970s, with courts and politicians from both parties enacting preemptions across a range of contentious issues. Thus, preemption is a critical feature of American policymaking—one that almost certainly shapes the political choices of policymakers, organized interests, and voters across levels of government. Despite its significance to the politics of policymaking, scholars have yet to systematically consider the political consequences of preemption. We apply the logic of policy feedback theory to create a framework for analyzing the political consequences of preemption. Specifically, we detail how the use of both federal‐state and state‐local preemption might produce unique resource and interpretive effects that shape the subsequent political behaviors of policymakers, organized interests, and the public. We then consider two illustrative cases—federal preemption of state consumer financial protections and state preemption of local gender identity anti‐discrimination statutes—to demonstrate our framework's application. The article addresses a gap in the preemption literature and provides a critical extension of policy feedback theory, proposing a research agenda for future work to help better understand the politics of a widely used policy tool.
Effect of reduced glutathione on quality, lipid peroxidation and antioxidant potential of frozen‐thawed ring‐necked pheasant semen
Authors: Zuha Sumiyyah , Rakha Bushra Allah , Akhter Shamim , Ansari Muhammad Sajjad , Waseem Kainat 
Published: February 2024

AbstractReduced glutathione (GSH) is a natural redox force immediately consumed by cells to combat toxins. Today's world is shifting towards clean farming practices whence ring‐necked pheasants dependent on croplands are facing threats and sperm‐assisted reproductive techniques become indispensable in preserving this valuable species for game and meat purposes. This study aims at evaluating the cryosurvivability (motility, viability, plasma membrane and acrosomal integrity, DNA fragmentation) and antioxidant capacity (Free radical scavenging activity, LPO detection, Ferric reducing antioxidant power, mitochondrial status) of ring‐necked pheasant semen with GSH supplementation in the extender. Semen collected from ten males was pooled, divided and diluted with Beltsville poultry semen extender (1:5) containing 0.0, 0.2, 0.4, 0.6 and 0.8 mM GSH. Samples were cryopreserved, and sperm quality was evaluated post‐dilution, cooling, equilibration, and freeze–thaw. Free radical scavenging activity, total antioxidant potential, mitochondrial action and lipid peroxidation were assessed at post‐thawing. Sperm motility, plasma membrane and acrosomal integrity, viability and DNA integrity were recorded highest (p < .05) at 0.4 mM GSH compared to other concentrations and control at all the stages of cryopreservation. Similarly, sperm mitochondrial action, antioxidant potential and free radical scavenging capacity were recorded higher (p < .05) with 0.4 mM GSH at post‐thaw compared to other concentrations of GSH and control. Lipid peroxidation was recorded as highest (p < .05) in the control compared to GSH‐supplemented groups at post‐thaw. Hence, it is concluded that GSH at 0.4 mM preserves the quality and ROS scavenging capacity of cryopreserved ring‐necked pheasant sperm as an antioxidant.
Use of 6‐minute walk distance to predict lung transplant‐free survival in fibrosing non‐IPF interstitial lung diseases
Authors: Zanini Umberto , Luppi Fabrizio , Kaur Karina , Anzani Niccolò , Franco Giovanni , Ferrara Giovanni , Kalluri Meena , Mura Marco 
Published: February 2024

AbstractBackground and ObjectiveThe identification of progression in patients with fibrosing non‐idiopathic pulmonary fibrosis (IPF) interstitial lung diseases (ILDs) represents an ongoing clinical challenge. Lung function decline alone may have significant limitations in the detection of clinically significant progression. We hypothesized that longitudinal changes of 6‐min walk distance (6MWD) from baseline, simultaneously considered with measures of lung function, may independently predict survival and identifying clinically significant progression of disease.MethodsForced vital capacity (FVC), diffusing lung capacity (DLCO) and 6MWD were considered both at baseline and at 1 year in a discovery cohort (n = 105) and in a validation cohort (n = 138) from different centres. The primary endpoint was lung transplant (LTx)‐free survival.ResultsAverage follow‐up was 3 years in both cohorts. Combined incidence of deaths and LTx was 29% and 21%, respectively. No collinearity and no strong correlations were observed among FVC, DLCO and 6MWD longitudinal changes. While age, gender and BMI were not significant, 6MWD decline ≥24 m predicted LTx‐free‐survival significantly and independently from FVC and DLCO declines, with high sensitivity and specificity, in both the discovery and the validation cohorts. Although FVC and DLCO declines remained significant predictors of LTx‐free survival, 6MWD decline was more accurate than the proposed ATS/ERS/JRS/ALAT functional criteria. Results were confirmed after stratifying patients by baseline FVC.ConclusionLongitudinal declines of 6MWD are associated with poor survival in fibrosing ILDs across a wide range of baseline severity, with high accuracy. 6MWD longitudinal decline is largely independent from lung function decline and may be integrated into the routine assessment of progression.
Responding to crises in authoritarian environments: Russian think tanks between policy evaluation and state endorsement
Authors: Axyonova Vera 
Published: February 2024

AbstractIn the literature on policy advice and analytical communities in democratic settings, think tanks are often assumed to be carriers of new ideas that serve as an informed and independent voice in policy debates. However, how much intellectual independence do think tanks have in authoritarian environments? This article tackles this question in a case study of Russian think tanks' discursive responses to two protracted crises: the COVID‐19 pandemic and climate change. The study employs a combination of deductive and inductive techniques to identify the discursive strategies used by think tank experts in their publications covering the crises. The findings suggest that there are differences in how think tanks communicate crises, which can be attributed to their institutional structures and position vis‐à‐vis the state. In some cases, the think tanks resort to polarization and discreditation of Western governments' crisis response, while openly endorsing the Russian state. In other cases, they engage in rationalization and more neutral analyses of the pandemic and climate change. However, regardless of these differences, they rarely concentrate on domestic challenges. Instead, they geopoliticize the crises, overemphasizing problematic developments elsewhere in the world, thus shifting attention in the public discourse away from domestic emergencies.