bluuebunny/crossref_metadata_2025_split huggingface dataset:
Parenting a child with cancer and maintaining a healthy couple relationship: Findings from the Family Talk Intervention
Authors: Holm Maja , Lundberg Tina , Lövgren Malin , Ljungman Lisa 
Published: October 2023

AbstractBackgroundDespite the challenges that caring for a child with cancer brings for parents, little knowledge is available concerning the effects on the parents’ couple relationship. Furthermore, few interventions have been designed to support parents in their couple relationship. The aim of this paper was, therefore, to explore parents’ experiences of their couple relationship while having a dependent child with cancer and the support they received from a family‐based intervention, the Family Talk Intervention (FTI).MethodsData for this paper were taken from semi‐structured interviews performed in a pilot study of the FTI in the context of pediatric oncology. In total, 22 couples were interviewed after participating in the FTI. The interviews were transcribed and analyzed using qualitative content analysis.ResultsParents described how maintaining a couple relationship while living with childhood cancer could be very challenging and was not given the highest priority. The FTI was considered a way of providing important support to the couple and a chance for them to sit down together and listen to each other's perspectives on the situation. Parents described that the FTI had helped them gain an increased mutual understanding, sometimes also helping them to realize that they needed more extensive professional support in their relationship.ConclusionsLiving with childhood cancer and upholding a healthy couple relationship is challenging for parents. The FTI has the potential to support couples, mainly by providing opportunities for parents to communicate with each other. However, some couples may be in need of a tailored clinical intervention.
Improved survival of children and adolescents with classical Hodgkin lymphoma treated on a harmonised protocol in South Africa
Authors: Geel Jennifer , van Zyl Anel , Plessis Jan du , Hendricks Marc , Goga Yasmin , Carr Amy , Neethling Beverley , Hramyka Artsiom , Omar Fareed , Mathew Rema , Louw Lizette , Naidoo Thanushree , Ngcana Thandeka , Schickerling Tanya , Netshituni Vutshilo , Madzhia Elelwani , du Plessis Liezl , Kelsey Tom , Ballot Daynia E. , Metzger Monika L. 
Published: October 2023

AbstractBackgroundHistoric South African 5‐year overall survival (OS) rates for Hodgkin lymphoma (HL) from 2000 to 2010 were 46% and 84% for human immunodeficiency virus (HIV)‐positive and HIV‐negative children, respectively. We investigated whether a harmonised treatment protocol using risk stratification and response‐adapted therapy could increase the OS of childhood and adolescent HL.MethodsSeventeen units prospectively enrolled patients less than 18 years, newly diagnosed with classical HL onto a risk‐stratified, response‐adapted treatment protocol from July 2016 to December 2022. Low‐ and intermediate‐risk patients received four and six courses of adriamycin, bleomycin, vinblastine, and dacarbazine (ABVD), respectively. High‐risk patients received two courses of ABVD, followed by four courses of cyclophosphamide, vincristine, prednisone, and dacarbazine (COPDac). Those with a slow early response and bulky disease received consolidation radiotherapy. HIV‐positive patients could receive granulocyte colony‐stimulating factor and less intensive therapy if stratified as high risk, at the treating clinician's discretion. Kaplan–Meier survival analysis was performed to determine 2‐year OS and Cox regression to elucidate prognostic factors.ResultsThe cohort comprised 132 patients (19 HIV‐positive, 113 HIV‐negative), median age of 9.7 years, with a median follow‐up of 2.2 years. Risk grouping comprised nine (7%) low risk, 36 (27%) intermediate risk and 87 (66%) high risk, with 71 (54%) rapid early responders and 45 (34%) slow early responders, and 16 (12%) undocumented. Two‐year OS was 100% for low‐risk, 93% for intermediate‐risk, and 91% for high‐risk patients. OS for HIV‐negative (93%) and HIV‐positive (89%) patients were similar (p = .53). Absolute lymphocyte count greater than 0.6 × 109 predicted survival (94% vs. 83%, p = .02).ConclusionIn the first South African harmonised HL treatment protocol, risk stratification correlated with prognosis. Two‐year OS of HIV‐positive and HIV‐negative patients improved since 2010, partially ascribed to standardised treatment and increased supportive care. This improved survival strengthens the harmonisation movement and gives hope that South Africa will achieve the WHO Global Initiative for Childhood Cancer goals.
Immunohistochemical expression of TFF1 is a marker of poor prognosis in retinoblastoma
Authors: Aschero Rosario , Ganiewich Daiana , Lamas Gabriela , Restrepo‐Perdomo Camilo A , Ottaviani Daniela , Zugbi Santiago , Camarero Sandra , Néspoli Ezequiel , Vilanova Maria Cuadrado , Perez‐Jaume Sara , Pascual‐Pasto Guillem , Sampor Claudia , Grigorovski Nathalia , Salas Beatriz , Suñol Mariona , Carcaboso Angel M. , Mora Jaume , de Dávila María T G , Doz François , Radvanyi François , Abramson David H , Llera Andrea S , Schaiquevich Paula S , Lubieniecki Fabiana , Chantada Guillermo L 
Published: October 2023

AbstractIntroductionThe risk of relapse in retinoblastoma is currently determined by the presence of high‐risk histopathologic factors in the enucleated eye. However, the probability of developing metastatic disease is heterogeneous among these patients. Evaluating a biological marker to identify high‐risk patients could be useful in clinical setting. This study aims to evaluate whether the expression of TFF1, a surrogate for subtype 2 retinoblastoma, is a prognostic marker for relapse and death.MethodsThis multicenter cohort study included 273 patients, 48 of whom had extraocular disease. Immunohistochemical staining were performed for CRX, ARR3, TFF1, and Ki67. Tumors were classified as histological subtype 1 (HS1) if they had low or no expression of TFF1 (quick score (QS) ≤ 50) and as histological subtype 2 (HS2) if they expressed TFF1 diffusely (QS > 50). We studied the association between HS classification and outcome.ResultsOf 273 patients, 35.9% were classified as HS1, 59.3% as HS2 and 4.8% were not evaluable. In multivariate analysis, patients with HS2 tumors had a higher probability of relapse and death than those with HS1 (p < .0001 and p = .00020, respectively). We identified a higher‐risk subgroup among HS2 tumors, presenting non‐mutually exclusive expression of ARR3 and TFF1 and had an increased risk of relapse and death compared with tumors that displayed mutually exclusive expression (p = .012 and p = .027, respectively).ConclusionsExpression of TFF1, especially when it is not‐mutually exclusive with ARR3, is an independent significant marker of poor outcome in retinoblastoma.
A multi‐institutional feasibility study of intra‐arterial chemotherapy in children with retinoblastoma. A Children's Oncology Group study (COG ARET12P1)
Authors: Chintagumpala Murali , Piao Jin , Gombos Dan , Chevez‐Barrios Patricia , Brock Lindsay , Dunkel Ira J. , Jubran Rima , Leahey Ann M. , Kim Jonathan , O'Brien Joan , Shields Carol L. , Rodriguez‐Galindo Carlos 
Published: October 2023

AbstractBackgroundIntra‐arterial chemotherapy (IA) as a treatment to salvage the eye with advanced retinoblastoma is increasingly utilized based on successes reported by institutions around the world mainly through retrospective studies.ObjectiveTo study the feasibility of delivering melphalan directly into the ophthalmic artery in a multi‐institutional prospective study in children with newly diagnosed unilateral group D retinoblastoma.MethodsThe Children's Oncology Group (COG) initiated study ARET12P1 in 2014 and was open to nine institutions. Eligible patients older than six months of age were enrolled. The feasibility of delivering three injections of melphalan into the ophthalmic artery every 28 days was assessed.ResultsNine institutions participated in this trial. Fourteen patients were enrolled, two of whom were unevaluable for feasibility. Four patients experienced a feasibility failure. In two patients, the ophthalmic artery could not be accessed for the second IA injection, in one the artery could not be accessed for the first injection, and one patient experienced grade 4 hypotension during the procedure.ConclusionDelivery of prescribed therapy within the context of this study did not meet the feasibility goals of the study with only a 67% feasibility success rate. These results should caution centers that plan to initiate this treatment and suggest investment in training to achieve technical expertise or referral to centers with expertise.
Layer ablation and surface textured of Carbon fiber reinforced plastics by infrared pulsed laser
Authors: Li Shaolong , Wang Lin , Yang Wenfeng , Wang Wenxuan , Wang Disheng , Li Zihao , Teng Zhan 
Published: October 2023

AbstractFor high‐quality composite bonded repairs, the research utilized a 1064 nm infrared pulsed laser to obtain geometry and texturing surface. The impact of grinding and laser treatment (0.4, 0.7, and 1.5 J/cm2) on the surface features of composite material was investigated, along with the tensile strength and failure modes. Findings demonstrated that laser treatment could significantly enhance surface roughness parameters and wetting properties compared to grinding. Additionally, an optimal laser energy density of 0.7 J/cm2 achieves complete resin removal without fiber damage while creating a laser‐induced periodic surface structure (LIPSS) based on a fiber weaving texture. The research revealed the synergistic bonding mechanism of “submicron mechanical locking” and “micron anchoring.” Laser treatment enhances the tensile strength of repaired specimens to 445 MPa, which was 90% of the original specimens, and substrate fracture was the associated failure mode.Highlights
This paper applies laser technology to simultaneously achieve 3D geometry and surface texture on composites bonded repairs.
A laser‐induced periodic surface structure was achieved while the resin was completely removed without carbon fiber damage.
The tensile recovery rate of the laser‐treated sample was satisfied with the requirements of aircraft maintenance.
Symmetric SPH modeling of functionally graded nanocomposite plates subjected to low‐velocity impact
Authors: Li Jiao , Lin Jun , Naceur Hakim , Kong Weizhen , Ji Shengcheng , Guan Yanjin , Quan Dong , Chen Jinqiang , Li Yunjiang 
Published: October 2023

AbstractFunctionally graded (FG) composites reinforced by carbon nanotubes (CNTs) have received extensive attention due to their excellent mechanical properties. The impact responses of FG‐CNT nanocomposites are analyzed by the developed meshless method. The temperature‐dependent material properties are expressed by way of the extended rule of mixture. The kinematics of the composite plate is established on the basis of the first‐order shear deformation theory. The modified Hertzian contact law is adopted to evaluate the impact loading between the plate and the impactor. The dynamic balance equations of the plate are constructed and computed by the Systemic Smoothed Particle Hydrodynamics (SSPH) method with strengthened prediction ability. The impacting behaviors of the FG‐CNT nanocomposite plate, as well as the parametric effects, are analyzed by the developed model and the suitability is clearly demonstrated.Highlights
Impact of FG‐CNTRC is firstly solved by a self‐developed meshless SPH model.
Strong capacity of the SPH impact model is clearly demonstrated.
More CNTs close to the strike face would improve the impact resistance.
Fetal circulatory physiology and brain development in complex congenital heart disease: A multi‐modal imaging study
Authors: Juergensen Stephan , Liu Jing , Xu Duan , Zhao Yili , Moon‐Grady Anita J. , Glenn Orit , McQuillen Patrick , Peyvandi Shabnam 
Published: October 2023

AbstractObjectiveFetuses with complex congenital heart disease have altered physiology, contributing to abnormal neurodevelopment. The effects of altered physiology on brain development have not been well studied. We used multi‐modal imaging to study fetal circulatory physiology and brain development in hypoplastic left heart syndrome (HLHS) and d‐transposition of the great arteries (TGA).MethodsThis prospective, cross‐sectional study investigated individuals with fetal congenital heart disease and controls undergoing fetal echocardiography and fetal brain MRI. MRI measured total brain volume and cerebral oxygenation by the MRI quantification method T2*. Indexed cardiac outputs (CCOi) and vascular impedances were calculated by fetal echocardiography. Descriptive statistics assessed MRI and echocardiogram measurement relationships by physiology.ResultsSixty‐six participants enrolled (control = 20; HLHS = 25; TGA = 21), mean gestational age 33.8 weeks (95% CI: 33.3–34.2). Total brain volume and T2* were significantly lower in fetuses with cardiac disease. CCOi was lower in HLHS, correlating with total brain volume ‐ for every 10% CCOi increase, volume increased 8 mm3 (95% CI: 1.78–14.1; p = 0.012). Echocardiography parameters and cerebral oxygenation showed no correlation. TGA showed no CCOi or aortic output correlation with MRI measures.ConclusionsIn HLHS, lower cardiac output is deleterious to brain development. Our findings provide insight into the role of fetal cardiovascular physiology in brain health.
Optimal design and operation of reactive extrusion processes: Application to the production and scale‐up of polyurethane rheology modifiers for paints
Authors: Cegla Maximilian , Fage Aleksandra , Kemmerling Simon , Engell Sebastian 
Published: October 2023

AbstractIn this work, the methodology for the optimal design, operation and scale‐up of reactive extrusion processes in twin‐screw extruders previously presented in Reference (Cegla and Engell, 2023). is applied to the production of hydrophobically ethoxylated urethanes (HEURs). The new process is a promising alternative to the current batch technology in large reactors with long residence times. We demonstrate the use of model‐based design and scale‐up for this case. A novel mechanistic finite volume twin‐screw extruder model is used as the process model, which is adapted to the process at hand by embedding a detailed description of the HEUR chemistry and rheology. An economic cost function is used to examine the scale‐up process from an 18 mm extruder to a 27 and 75 mm extruders, considering a selected range of products. The comparison between the optimization results obtained for the individual products with the optimization results for the production of multiple material grades using the same screw setup shows the high flexibility of the extruder‐based process. Significant energy savings compared with the conventional batch process can be achieved using reactive extrusion. To quantify the effort for the transition to a purely continuous production in terms of flexibility and process logistics, product changeovers are investigated.Highlights
Intensification of the HEUR production by reactive extrusion.
Detailed model for the twin‐screw extruder and the chemistry.
Optimization of extruder, screw design, and operating conditions.
Model‐based scale‐up from laboratory to industrial scale.
Investigation of flexible industrial production of different HEURs.
Study on the interaction between fluoroelastomer and silica: Characterizations
Authors: Zhang Hao , Zhao Lina , Zhang Chaoqun , Xu Yi , Jia Weijie 
Published: October 2023

AbstractDue to their excellent chemical stability, fluoroelastomers have been widely used in various severe circumstances since birth. At present, carbon blacks and inorganic fillers are the two most prominent reinforcing agents in fluoroelastomers. However, despite the rise of silica in the rubber industry, it is still difficult to apply this non‐carbon filler alone as a reinforcing agent in fluoroelastomer. Research on the interaction between silica and fluoroelastomer is even less and not systematical. Based on the above, we analyzed the interaction between silica and fluoroelastomer under different conditions through x‐ray photoelectron spectroscopy (XPS), Fourier‐transform infrared spectroscopy, bound rubber (BR) content analysis and rheological properties, and so forth. The interaction between fluoroelastomer and silica can be characterized by the binding energy variation at different temperatures (especially 260°C the new peak at about 685 eV) and wavenumber shift of Si–OH and Si–O–Si in XPS and infrared (IR) analysis, respectively. The BR content varied with loading, temperature, and atmosphere, reflecting the strength of the interaction from a macro perspective. The evolution of the rheological curves of different recipes and test conditions correlate closely with the results of XPS, IR, and BR content analysis, which also shows the sensitive response of polymer‐filler interaction to temperature and load. The observation results of transmission electron microscopy (TEM) directly demonstrate the differences in the dispersion of fillers at different temperatures. The proposed mechanism of fluoroelastomer–silica interaction mode will provide us with novel approaches to the applications of silica in the fluorine industry.Highlights
X‐ray photoelectron spectroscopy analysis indicates new fluorine species on the interfaces.
Infrared and bound rubber tests verify the fluoroelastomer–silica interactions.
Rheological curves reflect the interaction strength.
Investigation of the influence of salt remelting process on the mechanical, tribological, and thermal properties of 3D‐printed poly(lactic acid) materials
Authors: Yilmaz Sinan , Eyri Busra , Gul Okan , Karsli N. Gamze , Yilmaz Taner 
Published: October 2023

AbstractIn recent years, three‐dimensional (3D) printing has become the most popular of the additive manufacturing methods. This is because fused deposition modeling has many advantages over conventional manufacturing methods, such as enabling difficult‐to‐manufacture designs, producing less waste, and so forth. However, the parts produced by this method cannot be efficiently used in machine parts due to their relatively low mechanical properties. The main reason for the low mechanical properties of these parts is the poor bonding between the layers and between the fused filaments. The objective of this study is to overcome this disadvantage by implementing a heat treatment process called salt remelting. For this purpose, a remelting process was applied to 3D‐printed poly(lactic acid) (PLA) samples by holding them in a pot filled with manually compressed powdered salt at 210°C for 45 min and then cooling them to room temperature in a furnace. The untreated and remelted 3D‐printed PLA samples were then characterized by tensile test, three‐point bending test, and hardness test to investigate the mechanical properties. The remelted samples exhibited improved mechanical properties compared to the untreated samples, and this result was attributed to the interlayer bonding and reduction of voids in the microstructure. These results were also consistent with the thermal and morphological analysis results.Highlights
This study focuses on the characterization of salt‐remelted 3D‐printed PLA.
Salt melt process parameters have been optimized for 3D‐printed PLA.
Thermal, mechanical, tribological, and morphological properties were investigated.
It was found that the salt remelting method had a significant improving effect on the mechanical properties.
Omics insights into the responses to dietary selenium
Authors: Arias‐Borrego Ana , Callejón‐Leblic Belén , Collado Maria Carmen , Abril Nieves , García‐Barrera Tamara 
Published: October 2023

AbstractSelenium is a well‐known health‐relevant element related with cancer chemoprevention, neuroprotective roles, beneficial in diabetes, and in several infectious diseases, among others. It is naturally present in some foods, but deficiency in people led to the production of nutraceuticals, supplements, and functional food enriched in this element. There is a U‐shaped link between selenium levels and health and a narrow range between toxic and essential levels, and thus, supplementation should be performed carefully. Omics methodologies have become valuable approaches to delve into the responses of dietary selenium in mammals that allowed a deeper knowledge about the metabolism of this element as well as its biological role. In this review, we discuss omics approaches from the workflows to their applications that has been previously used to deep insight into the metabolism of dietary selenium. There is a special focus on selenoproteins, metabolomics responses in blood and tissues (e.g., brain, reproductive organs, etc.) as well as the impact on gut microbiota and its metabolites profile. Thus, we mainly reviewed heteroatom‐tagged proteomics, metallomics, metabolomics, and metataxonomics, usually combined with transcriptomics, genomics, and other molecular methods.
Synthesis of sulfhydryl‐functionalized polymers for the efficient adsorption of Pd2+ and Ag+ from aqueous solution
Authors: Fu Yuli , Duan Wenxiu , Chen Jiaqi , Wang You , Cao Yiwen , Wang Bin , Zhong Shihua , Xu Mancai , Lei Ting , Huang Jianhan 
Published: October 2023

AbstractHerein, two sulfhydryl‐functionalized polymers, namely, EDT‐HCPS and TMPMP‐HCPS, were synthesized according to the Friedel‐Craft s alkylation and nucleophilic substitution, and they were used to adsorb Pd2+ and Ag+ from aqueous solution. The Friedel‐Crafts alkylation offered the polymers with hyper‐cross‐linking frameworks composed of plentiful rigid methylene. The nucleophilic substitution brought abundant functional SH groups (the sulfur contents were 12.6 and 9.4 wt%, respectively) to the polymers. The adsorption results showed that the capacities of Pd2+ and Ag+ on EDT‐HCPS were larger than TMPMP‐HCPS, and the higher quantities of functional SH groups and the porosity played a beneficial role. The equilibrium data can be characterized by the Langmuir model, and the maximum capacities of Pd2+ and Ag+ on EDT‐HCPS at 308 K were predicted to be 383.92 and 212.93 mg g−1, respectively. The produced polymers represented superior adsorption selectivity, reproducibility, and reusability, demonstrating their excellent performance for the adsorption of Pd2+ and Ag+, and analysis of the adsorption mechanism demonstrated that the SH groups played a major role due to the strong chemical complexation of the functional SH with Pd2+/Ag+.
Two‐way shape memory properties study of crosslinked cycloolefin/dicyclopentadiene copolymer
Authors: Li Xuan , Yao Jiabin , Peng Deqian , Wang Xian , He Xuelian 
Published: October 2023

AbstractThe two‐way shape memory polymers (2 W‐SMPs) have garnered significant interest from researchers due to their great performance and wide range of applications. In this study, we present the synthesis and assessment of crosslinked copolymers P(CDD‐co‐DCPD) and P(COE‐co‐DCPD) using dicyclopentadiene and different comonomers via ring‐opening metathesis polymerization (ROMP). The two‐way shape memory behavior of these copolymers was altered by not only varying the species and incorporation level of a second comonomer, but also by adjusting the concentration of the second comonomer. The results indicated that the melting and crystalline temperature of the crosslinked copolymer decreased with increasing content of DCPD. Additionally, it was observed that the P(CDD‐co‐DCPD) copolymers exhibited one‐way shape memory function rather than two‐way shape memory performance under constant stress. With the increasing content of DCPD in the copolymers, the shape recovery ratio exhibited an upward trend and reached a maximum of 94.44%. Additionally, the shape fixation ratio of the P(CDD‐co‐DCPD) copolymers also surpassed 95%. In contrast, the P(COE‐co‐DCPD) copolymers demonstrated both one‐way and two‐way shape memory functions, particularly, when the molar content of DCPD was 4 mol%, the shape recovery ratio reached a maximum of 95.03% and the shape fixation ratio exceeded 90%.