bluuebunny/crossref_metadata_2025_split huggingface dataset:
PD-1 + CD8 + TILs and CD57 + CD8 + TALs are associated with Prognosis of Patients with Advanced HGSOC
Authors: He Tianhui , Zhang Jie , Zeng Lin , Yin Zhongnan , Shang Chunliang , Yu Bo , Zhang Xi , Yang Xiaoxue , Xue Lixiang , Guo Hongyan 
Published: February 2024

Abstract
Objective
Programmed cell death protein-1 (PD-1) expression is associated with activation and exhaustion of CD8+ T-cells, and CD57 is a marker of senescence. The impact of PD-1+CD8+ T-cells and CD57+ CD8+ T-cells on the prognosis of patients with advanced high-grade serous ovarian cancer (HGSOC) is unclear.
Methods
The percentage of PD-1+ and CD57+ among CD8+ T-cells was assessed by flow cytometry in tumor-infiltrating lymphocytes (TILs, n = 67) and tumor ascites lymphocytes (TALs, n = 74). To better stratify the survival risk, the optimal cutoff for the frequency of PD-1+ and CD57+ in CD8+ TILs and CD8+ TALs were obtained by the log-rank maximization method. Proliferation and functional properties of PD-1+CD8+ T-cells and CD57+ CD8+ T-cells were assessed in vitro.
Results
Patients with higher PD-1+CD8+ TILs (> 87.8%) have longer platinum-free interval (PFI) and overall survival (OS). Patients with higher CD57+CD8+ TALs (> 32.66%) are more likely to be resistant to chemotherapy and have lower complete remission rates, shorter PFI and OS. Multivariate analysis showed that the composite score of PD-1+CD8+ TILs and CD57+CD8+ TALs was an independent prognostic factor. The status of PD-1+CD8+ TILs and CD57+CD8+ TALs was significantly associated with tumor microenvironment specific immunophenotypes. PD-1+CD8+ TILs were still in a precursor exhaustion state with stem cell properties and high proliferative ability. CD57+CD8+ TALs exhibited senescence features, with impaired proliferation ability and secreted superfluous pro-inflammatory cytokines that aggravate immunosuppression.
Conclusions
This study suggests the potential of PD-1+CD8+ TILs and CD57+CD8+ TALs at diagnosis as prognostic biomarkers in advanced HGSOC.
Modeling Fluctuations in Daily Sunspot Numbers Using White Noise Analysis
Authors: Toledo Reynan , Bernido Christopher , Reyes Reinabelle 
Published: February 2024

Abstract
In this work, we model the fluctuations in daily sunspot numbers, denoted by X(t), as a modulated Brownian motion using a white noise analysis framework. We analyze data from the past 15 solar cycles with a complete record (Solar Cycles 10 to 24) and characterize the deviations in X(t) over timescales from 1 to ∼ 2000 days. We demonstrate that the observations can be adequately matched by a white noise model with 3 parameters: an amplitude parameter N, a decay parameter β, and a memory parameter μ. By matching the model with the observed time series from individual solar cycles, we are able to characterize the properties of each as well as potentially detect evolution in the stochastic component of the sunspot time series over the last ∼100 years. The approach followed here can also be readily applied to other indices of solar activity.
Computational and Synthetic Approach with Biological Evaluation of Substituted Thiazole Derivatives as Small Molecule L858R/T790M/C797S Triple Mutant EGFR Inhibitors Targeting Resistance in Non-Small Cell Lung Cancer (NSCLC)
Authors: Shinde Sonali S. , Sarkate Aniket P. , Rathod Sanket S. , Kilbile Jaydeo T. , Chaudhari Somdatta Y. , Tiwari Shailee V. , Yadala Rajesh , Pawar Smita C. , Bhandari Shashikant V. 
Published: February 2024

Abstract
The present research work explains the potential of novel substituted thiazole derivatives as anticancer agents along with molecular docking, DFT, ADMET, drug-likeness, and dynamics by simple chemical reaction. The synthesized derivatives were assessed against overexpressed wild-type EGFR (DU145) prostate, (MCF7) breast, (A549) lung, and L858R/T790M mutant EGFR (H1975) lung cancer cells. The compounds 4b and 4c showed good anticancer activity. The biological evaluation has been supported by computational studies such as simulation study, density functional study, and pharmacokinetic prediction.
Spatiotemporal Characteristics of the Coherent Structures in a Flow Over a Forest Canopy
Authors: Accary Gilbert 
Published: February 2024

Abstract

Large-Eddy Simulations of the development of Kelvin-Helmholtz instability and the transition to turbulence in an atmospheric boundary layer flow over a canopy are carried out using the hydrodynamic module of FireStar3D. The simulations were conducted by combining five different wind velocity (1, 3, 5, 8, and 12 m/s at the top of the canopy) and three leaf-area indices (0.5, 2, and 8) with variable leaf-area density. As long as the average wind speed was maintained at the top of the canopy, it was observed that the flow field was not significantly affected by canopy density, despite the higher drag exerted by the denser canopy. The wave-number and frequency spectra of the stream-wise velocity at the canopy surface was analysed at steady state. The analysis revealed the presence of a continuous spectrum of frequencies and wavelengths, indicating a fully developed turbulent flow. More importantly, the analysis describes the wavelength and frequency dependence of the normalized amplitude of the Fourier transforms of the stream-wise velocity at the top of the canopy. This normalized amplitude exhibits an exponential decay with a slope of − 0.5 with the normalized wave-number. At low frequencies, the normalized amplitude is globally constant, while it decays at high frequencies with the Strouhal number according a power law of slope − 3.
Closest target on the frontier of the free disposal hull
Authors: Kao Chiang 
Published: February 2024

Abstract

In data envelopment analysis (DEA) the production possibility set (PPS) constructed from the observed decision making units (DMUs) under only the free disposability postulate is referred to as the free disposal hull (FDH), based on which efficiencies are measured. The conventional non-radial DEA models that take both the inputs and outputs into consideration seek the target on the FDH frontier that is farthest to the DMU to be assessed to measure efficiency. A consequence is that greater effort is needed to make an inefficient DMU efficient. This paper proposes a method to find the target on the frontier that is closest to the assessed DMU. The target is found by examining only the orthogonal projection points of the assessed DMU on the frontier and the weakly efficient corner points of the PPS that dominate the assessed DMU. The effort needed to reach this point is the least. The case of twenty-four non-life insurance companies in Taiwan widely used in the literature is used in this paper for illustrative purposes. Surprisingly, the difference between the longest and shortest distances can be hundreds of times, which implies that the effort for an inefficient DMU to become efficient can be reduced to less than one-hundredth of what is usually needed.
JEL Classification C61, C67
Identification of varieties of wheat seeds based on multispectral imaging combined with improved YOLOv5
Authors: Liu Wei , Liu Yang , Hong Fei , Li Jiaming , Jiang Quan , Kong Lingfei , Liu Changhong , Zheng Lei 
Published: February 2024

Abstract

The identification of seed variety is important in wheat production because the growth and yield are highly related with its variety. Traditional discrimination methods for wheat seed varieties were suffered with time consuming and contamination. In this study, multispectral imaging technology combined with improved YOLOv5s was proposed. Three optimal spectral bands images were selected from all 19 bands using Genetic algorithm and confusion matrix and then the new images were fused with the three band images. The improved YOLOv5s with CBAM module was developed to train the identification model of wheat varieties using fusion images. The experimental results showed that the average precision of the model from proposed method in test set reached 99.38% that were better than the traditional YOLOv5s model. Meanwhile, the evaluation indexes of the model such as P/%, R/%, F1/% and mAP/% were all higher than 90%. The results showed that the method could be used for wheat variety identification rapidly and non-destructively.
WITHDRAWN: Restricted AP based Channel Estimation for Cell-Free Massive MIMO System
Authors: Kumar Abhishek , Kumar Avinash , Yadav Ishwar Chandra 
Published: February 2024

Abstract

In this work, we propose a restricted access points (AP) based dynamic channel estimation for a sixth-generation (6G) cell-free massive multiple input multiple output (CF-mMIMO) system. In CF-mMIMO network architecture, a large number of APs are distributed over a wide area and connected to a centralized processing unit (CPU) through a lossless infinite capacity to serve a smaller number of user devices (UDs) simultaneously. The channel state information (CSI) between is active user and APs is an important parameter that needs to be estimated for establishing an efficient communication link among them. Thus, in this work, we propose a restricted APs based channel estimation for the channel between UD to APs at CPU in CF-mMIMO system. A correlated Rayleigh fading channel with spatial correlation is considered between UDs and APs. A minimum mean square error (MMSE) based channel estimation with pilot contamination is carried out for the proposed CF-mMIMO system. An analytical closed form expression is derived for estimated channel for the proposed restricted APs based 6G CF-mMIMO system. A MATLAB based thorough simulation analysis is carried out and the obtained result is compared with the state-of-art small cell cellular technique. It has been shown that the proposed channel estimation technique gives the near optimal performance in CF-mMIMO system.
Topicality Boosts Popularity: A Comparative Analysis of NYT Articles and Reddit Memes
Authors: Barnes Kate , Juhász Péter , Nagy Marcell , Molontay Roland 
Published: February 2024

Abstract

This study sheds light on interconnected topic dynamics across traditional news sources and social media platforms, emphasizing the influential role of topicality in shaping content popularity in social media. Using the Latent Dirichlet Allocation and BERTopic models, we define sets of 120 New York Times (NYT) topics to compare with 899,766 image-with-text memes from Reddit, showing that social media content aligns with many of the same topical patterns observed in news outlets. Topicality is formalized based on the temporal distributions of the topics over the past 5 years. Using these topicality features, the investigation reveals significant correlations between the rising popularity of NYT topics and increased average upvotes on Reddit, particularly evident in "innovator" memes posted during the early stages of a topic's prevalence in the NYT. Furthermore, topicality features show significant predictive power over other content-based control features in a CatBoost classifier prediction of viral Reddit memes.
Qualitative and quantitative impact of lithium carbonate pretreatment on the effective 131-I half-life in radioiodine therapy for hyperthyroidism: results from a retrospective study
Authors: Gao Xuemei , Wu Binbin , Zhou Qian , Liu Yan , Wang Ruihua 
Published: February 2024

Abstract
Objective: The aim of this study is to evaluate the impact of lithium carbonate pretreatment on the effective 131I half-life (EHL) in radioiodine therapy (RIT) for hyperthyroidism.
Design: This analysis of 225 patients diagnosed as hyperthyroidism at our institution between February 2015 and September 2021 was retrospectively registered (registration number: 2024-KY-0016, date: Jan 4, 2024).
Methods: The basic clinical and laboratory examination data before and after lithium carbonate pretreatment was recorded. Whether the EHL was extended by ≥ 0.5 days has been established as the grouping basis. The differences of the clinical factors between the two groups were analyzed, and possible factors predicting whether longer EHL could be achieved was carried out using logistic regression analyses.
Results and conclusions: The result showed that a 7-day lithium carbonate pretreatment could increase radioactive iodine uptake rate (RAIU) at 24 h (by 9.93%), EHL (by 8.17%), and decrease FT3 (by 20.85%), FT4 (by 11.93%) levels in hyperthyroidism patients in this retrospective study. It is indicated that not all patients with hyperthyroidism could achieve longer EHL after using lithium carbonate. Young female with positive TRAb, positive TgAb, low blood concentration of TPOAb, and/or short baseline EHL is more likely to achieve longer EHL after a short-term lithium carbonate administration.
BHHO-EAS metaheuristic applied to the NP-Hard wrapper feature selection multi-objective optimization problem
Authors: SASSI Mohamed , CHELOUAH Rachid 
Published: February 2024

Abstract

Faced with the increase in high-dimensional Big Data creating more volume and complexity, the feature selection process became an essential phase in the preprocessing workflow upstream of the design of systems based on deep learning. This paper is a concrete and first application of the new metaheuristic Harris Hawk Optimization Encirclement-Attack-Synergy (HHO-EAS) in solving the NP-Hard wrapper feature selection multi-objective optimization problem. This problem combines two contradictory objectives: maximizing the accuracy of a classifier while minimizing the number of the most relevant and non-redundant selected features. To do this we hybridized HHO-EAS to create the new metaheuristic Binary HHO-EAS (BHHO-EAS). We combined HHO-EAS to the sixteen transfer functions most used in the literature structured in a balanced way among the four main categories including S-Shaped, V-Shaped, Q-Shaped and U-Shaped. This wide range of transfer function allows us to analyze the evolution of BHHO-EAS’s skills according to the assigned transfer function and to determine which of them offer the best performances. We applied wrapper feature selection to the well-known NSL-KDD dataset with the deep learning Multi Layer Perceptron (MLP) classifier. We put BHHO-EAS in competition with three other well-known population based binary metaheuristics, BPSO, BBA and BHHO. The analysis of the experimental results, compared to the three other binary metaheuristics, demonstrated that BHHO-EAS obtained the best performance on 100% of the transfer functions. This is more particularly highlighted by the U-Shaped transfer functions, which give an acceptable compromise for the two objectives of the problem with an average accuracy of 96,4% and an average size of selected features of 20.
Geospatial Assessment of Aridity and Erosivi̇ty Indices in Northwest Somalia Usi̇ng the Corine Model
Authors: Ahmed Ali Hussein , Nur Abdiaziz Hassan , MOHAMED Abdinasir Abdullahi , Hasan Md. Faruq , Sarmin Susmita 
Published: February 2024

Abstract
The degree of soil erosion depends on the erodibility of the soil and the erosive agents. The primary energy source for soil detachment and transport in water erosion processes is rain and runoff. In the northwest region of Somalia, we thoroughly evaluated the aridity and erosivity indices. This study, aridity and erosivity indices and arid periods of Woqoyi Galbeed were assessed. In the CORINE methodology, four parameters are used to evaluate the potential and actual soil erosion risks: Soil erodibility, erosivity, topography (slope), and land cover. Fournier Precipitation Index and Bagnouls-Gaussen Drought Index were calculated using rainfall data that were measured from 2011–2019 in the region and temperature data that were taken from 50 meteorological stations. The study illustrates that most of the study area is under moderate erosion risk. Although a small portion of the Southern parts of the study areas have high erosion risk, these areas have low erosion risk due to the very steep slope. The Erosivity Index quantifies the effect of rainfall impact and also reflects the amount and rate of runoff likely to be associated with precipitation events. Evaluating the result of MFI and BGI overlaid shows that there is low erosivity risk in the northern part of the country. It includes the Bossaso, Aburin, Dararweyne, Burco, Xudun and Iskushuban weather stations. It is covering the area of 204978, 65km2, which represents 32.14% of the study area. This indicates that Northern part of the country, annual rainfall is low, whereas some areas like Erigabo and gebiley are relatively moderate in the MFI.
Spatiotemporal variation of projected drought characteristics in Iran under climate change scenarios using CMIP5-CORDEX product
Authors: Ghaemi Alireza , Hashemi Monfared Seyed Arman , Bahrpeyma Abdolhamid , Mahmoudi Peyman , Zounemat-Kermani Mohammad 
Published: February 2024

Abstract

This study aims to assess the change of drought characteristics (intensity, duration, and frequency) under the effect of climate change in Iran using the modified standardized precipitation index (MSPI) and theory of runs on annual and seasonal scales for three near-future, mid-future (MF), and far-future climates. Hence, regional climate models extracted from South Asia-Coordinated Regional Climate Downscaling Experiments (CORDEX-SA) are applied. Regarding the result, MSPI could assign the standardized precipitation index (SPI) values better than the conventional form of SPI during the historical period (HP). The outcomes revealed that the northeast stations will experience a decrease in intensity (up to 24.57% in MF compared with HP) until 2100 at seasonal timescale, while the duration and frequency of drought will be increased. Although the greatest increase in intensity changes of droughts (up to 91%) until the end of the century will happen in the eastern and southwestern regions of Iran, these regions will face the maximum decrease in the duration (−30.54%) and frequency (−25%) of droughts compared with HP at seasonal timescale. In addition, regarding the outcomes of this study, strategies can be adopted to better manage water resources for various regions of Iran.
A comparison of the performance of different innovative trend assessment approaches for air temperature and precipitation data: an application to Elazığ Province (Turkey)
Authors: Acar Ramazan 
Published: February 2024

Abstract
In this study, the temporal variability of monthly total precipitation and monthly average temperature data of Palu station were analyzed. In addition to statistical analysis such as Mann–Kendall (MK) and SR, innovative polygon trend analysis (IPTA), innovative trend analysis (ITA), and combination of Wilcoxon test and scatter diagram (CWTSD) methods were used in the study. A total of 24 trend analyses (for 12 months of precipitation and temperature data) were conducted for each method used for temperature and precipitation parameters in the study. Looking at the results of these methods, a decreasing trend was detected only in December for precipitation data, common to all methods. For temperature data, an increasing trend was detected only in February and March. With the application of the IPTA, an increasing trend in some months and a decreasing trend in other months were detected for the two parameters. The Wilcoxon test exhibits significant consistency with the MK and Spearman's Rho (SR) in terms of the statistical trend, according to the examination of temperature and precipitation data using the CWTSD approach, which is relatively recent. Furthermore, the visual trend analysis demonstrates high consistency between the NO-ITA and Şen-ITA approaches.
Surface modification of nanofiltration membrane using polyoxometalates for improved separation and antifouling performance
Authors: Lu Qi , Yang Haodong , Chen Zhe , Yao Lei 
Published: February 2024

Abstract

In this study, polyoxometalates (POMs) as a core-modifying material was used to fabricate the nanofiltration (NF) membrane on the polyvinylidene fluoride (PVDF) microfiltration membrane substrate via a novel interfacial polymerization (IP) method. The formation mechanism of the POMs-modified composite membrane was proposed. The separation and antifouling properties were further investigated. After cross-linking with POMs through the new IP reaction, the modified composite membrane showed improved hydrophilicity, water flux, and salt rejection. In the humic acid fouling experiment, the POMs-modified membrane exhibited the best antifouling performance, with a flux recovery rate of up to 91.3%. Electrochemical impedance spectroscopy was further used to investigate the antifouling performance of the membranes. Nyquist and Bode plots of the POMs-modified membranes showed no significant change before and after fouling compared to the PVDF membrane substrate, indicating reduced fouling attachment on the modified membrane, which was consistent with the fouling index and flux variation observed during the fouling experiment. Our findings provide a simple and valuable route for fabricating POMs-functionalized NF membranes with desirable separation and antifouling performance.
BNCC E FORMAÇÃO DE PROFESSORES
Authors: Temple Giovana Carmo , Moraes Fabio 
Published: February 2024

Considerando o contexto da Reforma do Novo Ensino Médio (2017), buscou-se promover possíveis aproximações entre os apontamentos críticos feitos pelo jovem Nietzsche, acerca do processo de industrialização pelo qual passou a educação alemã de sua época e os princípios formativos da BNC-formação (2019). Para tanto, realizou-se a análise das Diretrizes Curriculares Nacionais (DCNs) para a formação docente da educação básica, bem como o estudo sistemático das conferências Sobre o futuro dos nossos estabelecimentos de ensino (1872). A atualidade das contribuições do filósofo alemão sobre educação na modernidade, permitiu-nos lançar luzes sobre os principais dilemas atualmente enfrentados, pela educação brasileira, a respeito da Reforma do Novo Ensino Médio e da BNCC. Os resultados desse trabalho denunciam um modelo educacional em curso no Brasil, cujos princípios formativos estão alinhados a interesses muito específicos, o que nos levou a concluir que, no âmbito da Reforma, o interesse do Estado, alinhado aos interesses empresariais, resume-se a formar professores-treinadores, aptos a incorporar e ensinar (inculcar) as habilidades e as competências técnico-profissionais predeterminadas pelas DCNs.
Therapeutic benefits of Moringa oleifera: A Mini Review
Authors: Prajapati Sunil Kumar , Tilak Vijay Kumar , Dhakar Ram Chand , Arya Rajeshwar Kamal Kant , Nagar Jitendra , Nagar Chaman 
Published: February 2024

There are about thirteen species of Moringa trees in the family Moringaceae. Moringa oleifera Lam. (synonym: Moringa pterygosperma Gaertn.) is the most widely known species and reported many therapeutics uses in previous years. All part of the Moringa tree is useful in some way and people depends on it for their livelihood. The leaves of the Moringa tree are an excellent source of Nutrients like Minerals, Protein and Vitamins (A and C). Moringa tree has approximately 46 antioxidants and it is one of the cheapest sources of natural anti-oxidants. Anti-oxidants supply the free atoms needed by the human body and mitigate the effect of free radicals. M. oleifera contains active compounds such as flavonoids, tannins, saponins, alkaloids, phenolics, and triterpenoids which possess antibacterial effects. Moringa oleifera has high mineral and protein content and has been previously investigated for its potential in treating different oral soft tissue diseases. Present review summarises the various medicinal uses of Moringa oleifera. Keywords: Moringa oleifera, anti-inflammatory, Oral diseases, anti-diabetic