bluuebunny/crossref_metadata_2025_split huggingface dataset:
Meaningful consumer engagement in medical radiation sciences: enhancing quality improvement and research projects
Authors: Brown Amy , McCoola Brianna , Funnell Yovanna , Hargrave Catriona 
Published: December 2023

AbstractConsumer engagement and partnership are increasingly recognised as a significant component of healthcare planning, provision, quality improvement and research. This article provides an overview of consumer engagement embedded in two different projects: a quality improvement project and a research project. The considerations and steps taken to effectively engage and partner with consumers throughout both projects will be discussed such as the prompt for consumer engagement, how the consumer/s were recruited and their specific contributions. The commonly reported advantages and challenges as well as reflections on what we might do differently with the benefit of hindsight are presented, including time required by both consumers and health professionals; funding and remuneration; and reporting findings to the wider community. In demonstrating consumer engagement and our learnings, we aim to encourage further consumer engagement activities amongst medical radiation professionals.
Upper‐level wind mode over the North Atlantic‐Arctic Ocean leading to coherent variations of Eurasian and North American winter temperatures and weakness in the CMIP6 models
Authors: Sun Chenghu , Shi Xiaohui , Lu Qifeng , Li Weijing 
Published: December 2023

AbstractThis study discovers that the interannual synchronization of winter temperature anomalies between northern Eurasia and North America is closely related to variation in the second leading mode of the 300 hPa meridional wind anomalies (i.e., V300‐EOF2) over the North Atlantic‐Arctic Ocean. The V300‐EOF2 mode modulates the large‐scale Rossby wave propagating across the mid‐high latitudes of the Eurasian and North American continents at the mid‐high level of troposphere, and it also interferes with the climatological quasi‐stationary wavenumber‐2 to affect the stratosphere circulation, which facilitates the southward intrusion of cold air into Eurasia and North America simultaneously. This study also evaluated whether the CMIP6 high‐top (HT) models could more accurately represent the V300‐EOF2 mode and the associated modulation mechanism on synchronized temperature variation between Eurasia and North America than the low‐top (LT) models. The results demonstrate that although the multi‐model ensemble means (MME) of both the HT and LT models can reproduce the V300‐EOF mode, they all underestimate its modulation mechanism on atmospheric circulation and coherent temperature changes over mid‐latitude Eurasia and North America, with minor differences in simulation skill capability. Most importantly, although containing a full stratosphere, the HT models do not significantly improve their simulation ability to depict the observed linear interference between the anomalous wave‐2 and the climatological stationary wave‐2 compared to the LT models. Therefore, comparing to the LT models, the CMIP6 HT models present no clear advantages in reproducing the V300‐EOF2 mode and its associated low‐frequency climate anomalies. These results also have implications for the evaluation of the predictability of concomitant Eurasian‐North American cooling in the Subseasonal‐to‐Seasonal Prediction Project.
Gastric emptying and myoelectrical activity testing in children with esophageal atresia: A pilot study
Authors: Mussies Carlijn , Duvoisin Gilles , Le Angela , Birro Selin , Hulbert Sarah , Omari Taher , Benninga Marc A. , van Wijk Michiel P. , Krishnan Usha 
Published: December 2023

AbstractObjectivesAbnormalities of gastric function in children with esophageal atresia (EA) could potentially contribute to gastrointestinal symptoms and reduced quality of life (QOL). Therefore, we aimed to determine the feasibility and clinical usefulness of gastric function testing in children with EA.MethodsThe validated PedsQL Gastrointestinal Symptoms Questionnaire (PedsQL‐GI) was completed to assess gastrointestinal symptoms and symptom‐related QOL. Gastric emptying and gastric myoelectrical activity were studied using 13C‐gastric emptying octanoic acid breath test (13C‐GEBT) and surface electrogastrography (EGG). Correlations between 13C‐GEBT and EGG parameters and PedsQL‐GI scores were investigated.ResultsFifteen patients (four males) were included (median age: 6 [3.0–8.5] years). Mean PedsQL‐GI scores as reported by the children were comparable to the healthy population. However, parents reported a diminished QOL. Gastric function tests (gastric emptying and/or surface EGG) showed abnormalities in 12 patients (80%). Patients with abnormal slow waves showed abnormal gastric emptying coefficient more often. There was no significant association between 13C‐GEBT nor EGG results and PedsQL‐GI scores.Conclusions13C‐GEBT and EGG can be used to evaluate gastric function in patients with EA. Abnormal gastric function tests were present in 80% of our cohort. However, abnormal gastric function did not significantly correlate with reported gastrointestinal symptom‐related QOL.
Office‐based sedation‐free transnasal esophagogastroduodenoscopy with biopsies using single‐use gastroscopes: A pediatric single‐center experience
Authors: Smadi Yamen , Thomas Jessina , Bittar Khaled , Norton Hannah , Friedlander Joel A. , Bornstein Jeffrey 
Published: December 2023

AbstractIntroductionUnsedated transnasal endoscopy (TNE) as transnasal esophagoscopy (TN‐Eso) has emerged as a promising alternative to esophagogastroduodenoscopy (EGD) under sedation to assess eosinophilic esophagitis (EoE). We report our center's experience using single‐use gastroscopes to perform sedation‐free transnasal EGD (TN‐EGD) with biopsies in an office‐based setting.MethodsA retrospective review was performed on patients with eosinophilic esophagitis who underwent office‐based sedation‐free TNE with topical analgesia and virtual reality (VR) procedural dissociation and distraction. A sterile, single‐use, ultra‐slim 3.5 mm outer diameter, 110 cm long gastroscope with 2 mm working channel (EvoEndo) was used to perform TNE with biopsies/brushings. Data including demographics, procedure success rate, total visit time, biopsy adequacy, procedure time, procedural preference, and complications were collected.ResultsOffice‐based TNE was completed in 8 patients (six males, age range 11–20 years). The endoscope was advanced by an experienced transoral endoscopist successfully through the nares into stomach (transnasal esophagogastroscopy [TN‐EG]) in all subjects (100%) and into the duodenum (TN‐EGD) in seven subjects (87.5%). Biopsies were obtained from esophagus in all cases and from the stomach/duodenum in five cases. Histological assessment, esophageal brushing, disaccharidase enzyme analysis, or duodenal aspirate analysis were performed as indicated. EoE reevaluation was the primary indication to perform endoscopy in all patients. Visual and histologic findings were all adequate for assessment. There were no significant adverse events.ConclusionOffice‐based TN‐EGD with VR procedural distraction and dissociation using single‐use gastroscopes was effective to monitor EoE, gastritis, and duodenitis in a pediatric practice.
A robust method for simultaneous determination of eight B vitamins in human serum by liquid chromatography tandem mass spectrometry
Authors: Huo Yu‐Mei , Zhang Shang‐Qing , Wu Gao‐Ping , Shan Hong‐Bo , Pan Chao 
Published: December 2023

The level of vitamin B group in human serum is an important index of human health. Among B vitamins, cyanocobalamin in serum is unstable and its content is extremely low. Rapid and simultaneous detection of multiple B vitamins including cyanocobalamin is a challenge. Herein, we have developed a rapid and stable method that can realize the determination of thiamine, riboflavin, nicotinamide, pantothenic acid, pyridoxic acid, biotin, 5‐methyltetrahydrofolate, and cyanocobalamin simultaneously in 6 min. The method was established based on protein precipitation with methanol and then chromatographic separation was achieved using Waters acquity ultra‐high‐performance liquid chromatography high strength silica T3 column, which was stable and sensitive especially for cyanocobalamin. Limit of quantification, precision, trueness, and matrix effect were validated according to the European Medicines Agency and United States Food and Drug guidelines and Clinical and Laboratory Standards Institute guidelines on bioanalytical method. The limit of quantification for thiamine, riboflavin, nicotinamide, pantothenic acid, pyridoxic acid, biotin, 5‐methyltetrahydrofolate, and cyanocobalamin was 0.4, 0.4, 0.8, 2.0, 0.4, 0.1, 0.4, and 0.04 ng/mL separately, respectively. Intra‐ and interday precisions were 1.1%–12.4% and 2.0%–13.5%, respectively. The relative errors were between 0.3% and 13.3%, and the matrix effects were between 2.6% and 10.4%.
Tissue engineering in otorhinolaryngology: A knowledge‐based analysis
Authors: Padilla‐Cabello Javier , Martin‐Piedra Miguel A. , Santisteban‐Espejo Antonio , Moral‐Munoz Jose A. 
Published: December 2023

AbstractObjectiveTo analyze the impact, performance, degree of specialization, and collaboration patterns of the worldwide scientific production on tissue engineering in otorhinolaryngology at the level of countries and institutions.MethodsTwo different techniques were used, performance and science mapping analyses, using as samples all the available documents regarding tissue engineering focused on otorhinolaryngology applications. The dataset was retrieved from the Core Collection of the Web of Science database from 1900 to 2020. Social structure was analyzed using science mapping analysis with VOSviewer software.ResultsThe United States was the main producer, followed by Germany, and Japan. Malaysia and Germany had the highest Relative Specialization Index, indicating their greater relative interest in this area compared to other countries. The social structure analysis showed that the United States and Germany had significant co‐authorship relationships with other countries. The University of California System, Kyoto University, and Harvard University were the leading institutions producing literature in this field. These latter two institutions showed the largest number of collaborations, although most of them were with institutions within their own country. There was a lack of connections between different communities of research.ConclusionThe United States is the main country driving progress in this research area, housing the most notable institutions. However, significant collaborations between these research centers are currently lacking. Encouraging greater cooperation among these institutions and their researchers would promote the exchange of knowledge, ultimately facilitating and accelerating advancements in this field.
On the optimization of 3D inflow‐based vascular‐space‐occupancy (iVASO) MRI for the quantification of arterial cerebral blood volume (CBVa)
Authors: Gu Chunming , Li Yinghao , Cao Di , Miao Xinyuan , Paez Adrian G. , Sun Yuanqi , Cai Jitong , Li Wenbo , Li Xu , Pillai Jay J. , Earley Christopher J. , van Zijl Peter C. M. , Hua Jun 
Published: December 2023

AbstractPurposeThe inflow‐based vascular‐space‐occupancy (iVASO) MRI was originally developed in a single‐slice mode to measure arterial cerebral blood volume (CBVa). When vascular crushers are applied in iVASO, the signals can be sensitized predominantly to small pial arteries and arterioles. The purpose of this study is to perform a systematic optimization and evaluation of a 3D iVASO sequence on both 3 T and 7 T for the quantification of CBVa values in the human brain.MethodsThree sets of experiments were performed in three separate cohorts. (1) 3D iVASO MRI protocols were compared to single‐slice iVASO, and the reproducibility of whole‐brain 3D iVASO MRI was evaluated. (2) The effects from different vascular crushers in iVASO were assessed. (3) 3D iVASO MRI results were evaluated in arterial and venous blood vessels identified using ultrasmall‐superparamagnetic‐iron‐oxides–enhanced MRI to validate its arterial origin.Results3D iVASO scans showed signal‐to‐noise ratio (SNR) and CBVa measures consistent with single‐slice iVASO with reasonable intrasubject reproducibility. Among the iVASO scans performed with different vascular crushers, the whole‐brain 3D iVASO scan with a motion‐sensitized‐driven‐equilibrium preparation with two binomial refocusing pulses and an effective TE of 50 ms showed the best suppression of macrovascular signals, with a relatively low specific absorption rate. When no vascular crusher was applied, the CBVa maps from 3D iVASO scans showed large CBVa values in arterial vessels but well‐suppressed signals in venous vessels.ConclusionA whole‐brain 3D iVASO MRI scan was optimized for CBVa measurement in the human brain. When only microvascular signals are desired, a motion‐sensitized‐driven‐equilibrium–based vascular crusher with binomial refocusing pulses can be applied in 3D iVASO.
Triple‐tuned birdcage and single‐tuned dipole array for quadri‐nuclear head MRI at 7 T
Authors: Paška Jan , Wang Bili , Chen Anna M. , Madelin Guillaume , Brown Ryan 
Published: December 2023

AbstractPurposeThe purpose of this work was to design and build a coil for quadri‐nuclear MRI of the human brain at 7 T.MethodsWe built a transmit/receive triple‐tuned (45.6 MHz for H, 78.6 MHz for Na, and 120.3 MHz for P) quadrature four‐rod birdcage that was geometrically interleaved with a transmit/receive four‐channel dipole array (297.2 MHz for H). The birdcage rods contained passive, two‐pole resonant circuits that emulated capacitors required for single‐tuning at three frequencies. The birdcage assembly also included triple‐tuned matching networks, baluns, and transmit/receive switches. We assessed the performance of the coil with quality factor (Q) and signal‐to‐noise ratio (SNR) measurements, and performed in vivo multinuclear MRI and MR spectroscopic imaging (MRSI).ResultsQ measurements showed that the triple‐tuned birdcage efficiency was within 33% of that of single‐tuned baseline birdcages at all three frequencies. The quadri‐tuned coil SNR was 78%, 59%, 44%, and 48% lower than that of single or dual‐tuned reference coils for H, H, Na, and P, respectively. Quadri‐nuclear MRI and MRSI was demonstrated in brain in vivo in about 30 min.ConclusionWhile the SNR of the quadruple tuned coil was significantly lower than dual‐ and single‐tuned reference coils, it represents a step toward truly simultaneous quadri‐nuclear measurements.
Development and internal validation of a risk prediction model for stress urinary incontinence throughout pregnancy: A multicenter retrospective longitudinal study in Indonesia
Authors: Liang Surui , Huang Shijie , Andarini Esti , Wang Ying , Li Yan , Cai Wenzhi 
Published: December 2023

AbstractBackgroundThis study aimed to develop a risk prediction model for stress urinary incontinence (SUI) throughout pregnancy in Indonesian women.MethodsWe conducted a multicenter retrospective longitudinal study involving pregnant women in Indonesia, who sought care at obstetrics clinics from January 2023 to March 2023, encompassing all stages of pregnancy. We collected data on their predictive factors and SUI outcome. SUI was diagnosed based on responses to the “leaks when you are physically active/exercising” criterion in the ICIQ‐UI‐SF questionnaire during our investigation of the participants. The models underwent internal validation using a bootstrapping method with 1000 resampling iterations to assess discrimination and calibration.ResultsA total of 660 eligible pregnant women were recruited from the two study centers, with an overall SUI prevalence of 39% (258/660). The final model incorporated three predictive factors: BMI during pregnancy, constipation, and previous delivery mode. The area under the curve (AUROC) was 0.787 (95% CI: 0.751−0.823). According to the max Youden index, the optimal cut‐off point was 44.6%, with a sensitivity of 79.9% and specificity of 65.9%. A discrimination slope of 0.213 was found.ConclusionThe developed risk prediction model for SUI in pregnant women offers a valuable tool for early identification and intervention among high‐risk SUI populations in Indonesian pregnant women throughout their pregnancies. These findings challenge the assumption that a high BMI and multiple previous deliveries are predictors of SUI in Indonesian women. Further research is recommended to validate the model in diverse populations and settings.
Bladder management is the top health concern among adults with a spinal cord injury
Authors: Loftus Christopher J. , Ratanawong John P. , Myers Jeremy B. , Lenherr Sara M. , Stoffel John T. , Welk Blayne , Grove Shawn , Elliott Sean P. 
Published: December 2023

AbstractIntroduction and ObjectiveIndividuals with spinal cord injury (SCI) commonly experience secondary complications though it is not known how they prioritize these different health domains. Using the Neurogenic Bladder Research Group (NBRG) SCI registry, our objective was to identify the top health concerns of individuals with SCI and identify factors that may be associated with these choices with particular focus on urologic issues that participants face.MethodsParticipants in the NBRG registry were asked: “What are the top 3 problems that affect you on a daily basis?” Urinary symptoms and QoL were assessed with the Neurogenic Bladder Symptom Score (NBSS). Multivariate regression was used to identify factors related to selecting a top ranked health issue.ResultsAmong our 1461 participants, 882 (60.4%) were men and the median age was 45.1 years (IQR 25.3−64.9). Bladder management was the most commonly top ranked primary issue (39%) followed by pain (16.4%) and bowel management (11.6%). Factors associated with ranking bladder management as the primary concern included years since injury (OR 1.01 [1.00−1.02], p = 0.042), higher (worse) total NBSS (OR 1.05 [1.03−1.06], p < 0.001), and higher (worse) NBSS QoL (OR 1.25 [1.12−1.41], p < 0.001). Reporting chronic pain on a daily basis was associated with ranking pain as the primary health concern (OR 41.7 [15.7−170], p < 0.001).ConclusionsIn this cohort, bladder management was ranked as the top health issue and increasing time from injury was associated with increased concern over bladder management. More bladder symptoms were also associated with ranking bladder management as a primary concern while bladder management method and urinary tract infections rate were not.
Experimental and numerical investigations of VO2‐UHMWPE polymer composite plates across phase change temperature
Authors: Shakir Mohammed , Verma Divya , Balakrishnan Viswanath , Talha Mohammad 
Published: December 2023

AbstractIn the present study, experimental and numerical investigations are carried out on Vanadium dioxide (VO2)‐UHMWPE composite plates while considering the temperature across phase change. VO2 is known for semiconducting to metallic transition along with structural changes from monoclinic to tetragonal during heating above 68°C, which enhances structural stiffness. For the experimentation, VO2‐UHMWPE composite samples are fabricated by employing the Hot‐Press method. These samples are further utilized to perform the compression test in order to find Young's moduli at room temperature (RT) and 75°C (temperature across phase change) using a Universal Testing Machine (UTM). Based on the experimentally computed Young's moduli, the numerical investigations in terms of free vibration and bending analyses, are performed. For structural kinematics, a C0‐continuous higher‐order shear deformation theory (HSDT) is employed, and the governing equations are derived using the Lagrange model. The numerical results, that is, natural frequencies and center deflection, are assessed using the finite element method (FEM). The convergence and comparison studies are accomplished to ensure the performance and competence of the present numerical model within the framework of MATLAB and ABAQUS. The influence of temperature, thickness ratio, boundary conditions, etc. on the frequency and deflection of the bare UHMWPE polymer and VO2‐UHMWPE plates, is discussed in detail. Based on the results, it can be concluded that the VO2 reinforcement to the UHMWPE polymer improves structural stiffness at a temperature of 75°C. Moreover, VO2‐UHMWPE composite can be utilized for structural applications, wherein lightweight and high‐temperature resistive material is desired.Highlights
The fabrication of the VO2‐UHMWPE composite samples is accomplished through the Hot‐Press method.
Young's moduli of the VO2‐UHMWPE composites at RT and 75°C are assessed utilizing UTM.
The finite element method is employed to analyze the behavior of the bare UHMWPE polymer and VO2‐UHMWPE plates in free vibration and bending.
The effect of influencing parameters such as temperature, thickness ratio, boundary conditions, etc., on natural frequency and deflection of the plates are explored.
Emotion‐centered versus fact‐centered medical information to alleviate pain and anxiety in prostate biopsy: A randomized trial
Authors: Krausewitz Philipp , Schmeller Helene , Spitzer Carsten , Ellinger Jörg , Ritter Manuel , Petrowski Katja , Conrad Rupert 
Published: December 2023

AbstractBackgroundTo test the efficacy of emotion‐centered (EC) versus fact‐centered (FC) written medical information for prostate biopsy to alleviate pain and anxiety in a randomized controlled trial.MethodsIn a single‐center, single‐blinded study participants were randomized to receive FC or EC (DRKS00022361; 2020). In the EC, the focus was on possible stress reactions and stress‐reducing strategies. Participants were asked to complete questionnaires on the day of MRI acquisition (T0) directly before (T1) and after the procedure (T2). The primary outcome measure was the assessment of worst pain in the last 2 h measured by the adapted brief pain inventory. Secondary outcome measures included state anxiety measured by the state‐trait anxiety inventory and the subjective evaluation of the impact of the written medical information at T2. For statistical analysis, mixed models were calculated.ResultsOf 137 eligible patients, 108 (79%) could be recruited and were randomized. There was a significant effect for time for the outcome variables pain and anxiety. Regarding the comparison for the primary outcome variable worst pain there was a significantly lower increase from T1 to T2 after FC compared to EC (p < 0.004). The course of anxiety displayed no overall group differences. The FC was evaluated as significantly more helpful regarding stress, pain, and anxiety with moderate effect sizes.ConclusionsFC was favorable with regard to worst experienced pain, assuming that the brief introduction of emotional issues such as stress and coping in written information might be counterproductive particularly in men not used to these subjects.