bluuebunny/crossref_metadata_2025_split huggingface dataset:
Hypertension and hyperglycaemia are positively correlated with local invasion of early cervical cancer
Authors: Shen Tiantian , Zhao Jing , Li Wenhan , Wang Xiaoman , Gao Yumei , Wang Zehua , Hu Sha , Cai Jing 
Published: December 2023

BackgroundMetabolic disorders are involved in the development of numerous cancers, but their association with the progression of cervical cancer is unclear. This study aims to investigate the association between metabolic disorders and the pathological risk factors and survival in patients with early cervical cancer.MethodsPatients with FIGO IB1 (2009) primary cervical cancer who underwent radical hysterectomy and systematic pelvic lymph node dissection at our institution from October 2014 to December 2017 were included retrospectively. Clinical data regarding the metabolic syndrome and surgical pathology of the patient were collected. The correlations between metabolic disorders (hypertension, hyperglycemia, and obesity) and clinicopathological characteristics as well as survival after surgery were analyzed.ResultsThe study included 246 patients with clinical IB1 cervical cancer, 111 (45.1%) of whom had at least one of the comorbidities of hypertension, obesity, or hyperglycemia. Hypertension was positively correlated with parametrial invasion and poorly differentiated histology; hyperglycemia was positively correlated with stromal invasion; obesity was negatively associated with lymph node metastasis; but arbitrary disorder did not show any correlation with pathologic features. Hypertension was an independent risk factor for parametrial invasion (OR=6.54, 95% CI: 1.60-26.69); hyperglycemia was an independent risk factor for stromal invasion (OR=2.05, 95% CI: 1.07-3.95); and obesity was an independent protective factor for lymph node metastasis (OR=0.07, 95% CI: 0.01-0.60). Moreover, the patients with hypertension had a significantly lower 5-year OS rate (70.0% vs. 95.3%, P&lt;0.0001) and a significantly lower 5-year PFS rate than those without hypertension (70.0% vs. 91.2%, P=0.010).ConclusionHypertension and hyperglycemia are positively associated with local invasion of early cervical cancer, which need to be verified in multi-center, large scale studies.
HLA frequency distribution of the Portuguese bone marrow donor registry
Authors: Espada Eduardo , Ligeiro Dário , Trindade Hélder , Lacerda João F. 
Published: December 2023

IntroductionThe Portuguese donor Registry of CEDACE was the fifth largest per capita bone marrow donor Registry of the WMDA as of 2019 and has yet to be thoroughly analyzed. We aimed to characterize its various aspects, including demographics and HLA allele and haplotype frequencies, to evaluate the genetic matching propensity score and ultimately further develop it.MethodsWe described and compared characteristics of the donor population with census data and used an Expectation-Maximization algorithm and analyses of molecular variance to assess haplotype frequencies and establish phylogenetic distances between regions and districts within the country.ResultsWe identified 396545 donors, corresponding to 3.85% of the Portuguese population; the median donor age was 39 years, with 60.4% of female donors. Most donors were Portuguese nationals, although 40 other nationalities were present, with a significant proportion of donors from Brazil and Portuguese-speaking African Countries; almost all donors self-reported as Western, with the second largest group reporting African ancestry. There was an asymmetric contribution of donors from different districts and regions, with most coming from coastal districts and few from the southern districts and autonomous regions; foreign and self-declared non-Western donors were mainly located in the Metropolitan Area of Lisbon and the South. Although most donors were typed in three loci (HLA-A, HLA-B and HLA-DRB1), only 44% were also typed in HLA-C, 1.28% in HLA-DQB1 and only 0.77% in all five loci and in high-resolution. There were varying allele and haplotype frequencies across districts and regions, with the most common three loci, low-resolution haplotypes, being HLA-A*01~B*08~DRB1*03, A*29~B*44~DRB1*07 and HLA-A*02~B*44~DRB1*04; some haplotypes were more prevalent in the South, others in the North and a few in the autonomous regions; African and foreign donors presented relevant differences in haplotype frequency distributions, including rare haplotypes of potential interest. We also report on four loci, low-resolution frequency distributions. Using AMOVA, we compared genetic distances between districts and regions, which recapitulated the country's geography.DiscussionOur analysis showed potential paths to optimization of the Registry, including increasing the male donor pool and focusing on underrepresented districts and particular populations of interest, such as donors from Portuguese-speaking African countries.
A cost-effectiveness analysis of pre-pregnancy genetic screening for deafness: an empirical study in China
Authors: Lv Yipeng , Wang Zhili , Yuan Ling , Cheng Fan , Wu Hao , Wang Zhaoxin , Yang Tao , Chen Ying 
Published: December 2023

ObjectivesThis research aims to assess the effectiveness and cost-effectiveness of pre-pregnancy deafness screening policies.MethodsMarried couples from Shanghai, Beijing, and Suzhou in China were enrolled. We conducted high-throughput, pre-pregnancy genetic screenings for deafness in women and their partners. We compared the cost-effectiveness of deafness genetic screening with the status quo. The two-step screening (wife then partner) and following treatments and interventions were included in the decision tree model. We conducted a cost-effectiveness analysis based on the decrease in deaf newborns, healthy newborn births, and cost-utility analysis of pre-pregnancy deafness genetic screening separately. Cost, utility, and probability data used in the three models were collected from a survey combined with literature and expert consultants. A 5% discount rate and a series of one-way sensitivity analyses along with a Monte Carlo simulation were used to test the reliability of this research.ResultsBetween Jan 1, 2019, and Dec 31, 2021, we recruited 6,200 females and 540 male spouses from community health service centers in Shanghai, Beijing, and Suzhou. The incremental cost-effectiveness ratio (ICER) for reducing deaf newborn births was USD 32,656 per case and USD 1,203,926 per case for increasing one healthy newborn birth. This gap exists because of the overall decrease of newborn births. From the perspective of the whole society, deafness genetic screening is not cost-effective for reducing the overall quality-adjusted life years (QALY) in the population.DiscussionPre-pregnancy genetic testing is effective in decreasing the occurrence of congenital deafness. It is a cost-saving measure when compared with the costs of future medical expenditure and income loss for the affected families. However, such screening and preventive avoidance of pregnancy will decrease the population size and QALY. Only post-screening ART with PGT was shown to increase the birth of healthy newborns. Focusing on key groups such as premature births or consanguineous couples may improve the societal effects of screening.
Enhancing health outcomes for Māori elders through an intergenerational cultural exchange and physical activity programme: a cross-sectional baseline study
Authors: Oetzel John G. , Zhang Yingsha , Nock Sophie , Meha Pare , Huriwaka Huia , Vercoe Maramena , Tahu Tania , Urlich Joanne , Warbrick Rachel , Brown George , Keown Shirley , Rewi Poia , Erueti Bevan , Warbrick Isaac , Jackson Anne-Marie , Perry Tracy , Reddy Rangimahora , Simpson Mary Louisa , Cameron Michael P. , Hokowhitu Brendan 
Published: December 2023

BackgroundThe study offers baseline data for a strengths-based approach emphasizing intergenerational cultural knowledge exchange and physical activity developed through a partnership with kaumātua (Māori elders) and kaumātua service providers. The study aims to identify the baseline characteristics, along with correlates of five key outcomes.MethodsThe study design is a cross-sectional survey. A total of 75 kaumātua from six providers completed two physical functioning tests and a survey that included dependent variables based in a holistic model of health: health-related quality of life (HRQOL), self-rated health, spirituality, life satisfaction, and loneliness.ResultsThe findings indicate that there was good reliability and moderate scores on most variables. Specific correlates included the following: (a) HRQOL: emotional support (β = 0.31), and frequent interaction with a co-participant (β = 0.25); (b) self-rated health: frequency of moderate exercise (β = 0.32) and sense of purpose (β = 0.27); (c) spirituality: sense of purpose (β = 0.46), not needing additional help with daily tasks (β = 0.28), and level of confidence with cultural practices (β = 0.20); (d) life satisfaction: sense of purpose (β = 0.57), frequency of interaction with a co-participant (β = −0.30), emotional support (β = 0.25), and quality of relationship with a co-participant (β = 0.16); and (e) lower loneliness: emotional support (β = 0.27), enjoyment interacting with a co-participant (β = 0.25), sense of purpose (β = 0.24), not needing additional help with daily tasks (β = 0.28), and frequency of moderate exercise (β = 0.18).ConclusionThis study provides the baseline scores and correlates of important social and health outcomes for the He Huarahi Tautoko (Avenue of Support) programme, a strengths-based approach for enhancing cultural connection and physical activity.
A case study about the forest fire occurred on 05 July 2021 over Khenchela province, Algeria, using space-borne remote sensing
Authors: Guehaz Riad , Sivakumar Venkataraman 
Published: December 2023

In this study, space-borne remote sensing (Landsat-8, MODIS) was employed to evaluate the effects of forest fires occurring on 05 July 2021, over Khenchela province, Algeria. Our objective is to understand the severity of damage caused by the fire and its implications for vegetation and land cover. Utilizing the Normalized Difference Vegetation Index (NDVI) from MODIS data and Landsat-8 imagery, we report changes in vegetation health and land cover. To identify areas affected by forest fires and evaluate the severity of damage, the Normalized Burn Ratio (NBR) and Differenced Normalized Burn Ratio (dNBR) were calculated. Analysis showed that −1825.11 ha (1.21%) of the total area experienced severe burns, 3843.54 ha (2.54%) moderate to high severity burns, 3927.97 ha (2.59%) moderate to low severity burns and 9864.45 ha (6.51%) low severity burns. The area covered by vegetation decreased from 2014 to 2021, indicating a negative trend in vegetation cover over the study period.
Draft Genome of Nocardia canadensis sp. nov. Isolated from Petroleum-Hydrocarbon-Contaminated Soil
Authors: Alotaibi Fahad , Lee Soon-Jae , Lahrach Zakaria , St-Arnaud Marc , Hijri Mohamed 
Published: December 2023

The bacterial strain WB46 was isolated from the rhizosphere of willow plants (Salix purpurea L.) growing in soil contaminated with petroleum hydrocarbons. The strain was subjected to whole-genome shotgun sequencing using Illumina HiSeq. Its draft genome is 7.15 Mb, with a 69.55% GC content, containing 6387 protein-coding genes and 51 tRNA and 15 rRNA sequences. The quality and reliability of the genome were assessed using CheckM, attaining an estimated genome completeness of 98.75% and an estimated contamination of 1.68%. These results indicate a high-quality genome (>95%) and low contamination (<5%). Many of these genes are responsible for petroleum hydrocarbon degradation, such as alkane 1-monooxygenase (alkB) and naphthalene dioxygenase (ndo). 16S rRNA gene analysis, including in silico DNA–DNA hybridization (DDH) and average nucleotide identity (ANI), showed that strain WB46 belongs to the genus Nocardia, and the most closely related species is Nocardia asteroides. The strain WB46 showed a distance of 63.4% and sequence identity of 88.63%, respectively. These values fall below the threshold levels of 70% and 95%, respectively, suggesting that the strain WB46 is a new species. We propose the name of Nocardia canadensis sp. nov. for this new species. Interestingly, the sequence divergence of the 16S rRNA gene showed that the divergence only occurred in the V2 region. Therefore, the conventional V3–V4, V5–V7, or V8–V9 targeting metabarcoding, among others, would not be able to assess the diversity related to this new species.
Hubungan Pengetahuan dengan Sikap Ibu Hamil Tentang Pemanfaatan Buku KIA di Puskesmas Buleleng I
Authors: Indrayani Indrayani , Tedjasulaksana Regina , Darmapatni Made Widhi Gunapria 
Published: December 2023

The KIA Handbook is a health record book containing maternal and child health records as well as various information on how to maintain and care for maternal and child health. In fact, utilization for pregnant women is still low. The purpose of this study was to determine the relationship between knowledge and attitudes of pregnant women about the use of KIA Handbook at the Buleleng I Public Health Center. The study design used a cross sectional study. The research sample was pregnant women, totaling 73 people. The data collection instrument was in the form of a questionnaire regarding knowledge and attitudes about the use of KIA Handbook. The data were analyzed by the Kendall tau test b. The results showed that 43 pregnant women (58.9%) had a good level of knowledge about use of KIA Handbook. A total of 50 pregnant women (68.5%) had a positive attitude towards the use of KIA Handbook. The results of the bivariate analysis using the Kendall tau b test and the p value = 0.000. This means that there is a relationship between knowledge and attitudes of pregnant women about the use of KIA Handbook at the Buleleng I Public Health Center. The results of this study are expected that health workers always inform mothers about the use of KIA Handbook.
Informantes católicos en el mundo azucarero
Authors: Gutiérrez Florencia , Santos Lepera Lucía 
Published: December 2023

A principios del siglo XX, la Liga Democrática Cristiana envió a Tucumán a tres expedicionarios con el propósito de relevar las condiciones socio-laborales de los obreros azucareros. El viaje les permitió conocer, describir e informar a la dirigencia de la Liga sobre ese mundo distante y desconocido, que consideraban era imperioso intervenir para mejorar las condiciones de vida obrera y frenar el avance del socialismo. En el cruce de las aspiraciones de cientificidad, basadas en la observación directa, y los preconceptos clasistas y prejuicios morales, el diagnóstico promovió interrogantes y posibles respuestas para avanzar en la organización obrera. La travesía de los expedicionarios católicos, plasmada en el libro Por los ingenios de Tucumán. Impresiones de viaje, permite repensar una inédita experiencia de conocimiento, vinculación y acción nacida del catolicismo social a principios del siglo XX. El reto de este artículo es contribuir a una historia social interrelacionada que privilegie la mirada en torno a las posibilidades, incertidumbres y desafíos del catolicismo social para construir un diagnóstico del mundo azucarero y generar propuestas de acción en el norte argentino.
« Leave thy home, O youth, and seek out alien shores » : dépaysement et nostalgie dans A Time of Gifts de Patrick Leigh Fermor
Authors: Blanchet Béatrice 
Published: December 2023

Cette contribution explore l’expérience du dépaysement, conçu comme reconnaissance d’une altérité irréductible mais également comme domestication de l’étrangéité, dans A Time of Gifts, œuvre de l’écrivain britannique Patrick Leigh Fermor (1915-2011) qui retrace les prémices d’un périple effectué à pied de Londres à Istanbul (1933-1935). Faisant des territoires de l’altérité un enjeu de savoir et de pouvoir, le regard impérial s’est également déployé en Europe centrale, territoire de l’Autre proche. Le récit de Patrick Leigh Fermor semble constituer une exception notable au sein d’un genre fréquemment marqué du sceau de l’ethnocentrisme. L’étrangéité est appréhendée au prisme d’une culture classique conçue comme universelle, dont les références partagées définissent les géographies symboliques du proche et du lointain. L’altérité est dès lors fréquemment assimilée au familier, ce qui fait du dépaysement un retour aux origines autant qu’un détour vers l’inconnu. Le dépaysement conçu comme écartement et séparation demeure néanmoins une expérience fondatrice, décrite par Patrick Leigh Fermor comme conversion ontologique. Indissociable d’une réflexion sur le statut liminal de l’insider-outsider, l’expérience de l’étrangéité peut être appréhendée comme un rite de passage impliquant l’ébranlement des évidences ainsi que le devenir-autre. Le dépaysement est éprouvé dans une dimension spatiale en tant que franchissement géographique mais également dans son épaisseur temporelle dotée de polyphonie : publié en 1977, A Time of Gifts mêle ainsi la voix d’un jeune homme découvrant une Europe au bord de l’abîme aux réflexions de l’homme de lettres parvenu à maturité, expérimentant comme arrachement l’irréversible destruction des êtres et de lieux par les tragédies de l’Histoire. Cette oscillation narrative et mémorielle entre l’ici et l’ailleurs, mais également entre le présent et le passé, fait de la nostalgie – étymologiquement associée à l’éloignement des lieux familiers et à l’abolition du passé originel – le contrepoint indissociable du dépaysement.
Le corps dépaysé : la migration transsexuelle et la prostitution dans le récit de voyage brésilien A Princesa
Authors: Fois-Braga Humberto 
Published: December 2023

A Princesa: depoimentos de um travesti brasileiro a um líder das Brigadas Vermelhas (1995) [Princesse : les déclarations d’une travestie brésilienne à un leader des Brigades Rouges] est un récit mémorialiste écrit à partir de notes prises par la transsexuelle et prostituée brésilienne Fernanda Alburquerque alors qu’elle purgeait une peine de prison en Italie dans les années 1990. Fernanda raconte sa vie depuis son enfance au sertão (région pauvre, aride et traditionnelle du Nord-est brésilien) jusqu’au moment de son arrestation en Italie. Cet article propose de dévoiler comment la mobilité physique de Fernanda, qui a parcouru et vécu dans une dizaine de villes brésiliennes et européennes, aura des conséquences dans la construction d’une performance de son corps transsexuel. Ensuite, et toujours par rapport à ce trajet plein de préjugés et de découverte de sa sexualité, notre recherche se penchera sur les motivations qui ont amené Fernanda à avancer dans son projet de migration, tandis qu’elle est incapable de retourner chez sa mère. On s’aperçoit pour finir que Fernanda se trouve toujours en mouvement parce qu’elle n’arrive jamais à concevoir de façon harmonieuse sa sexualité et son plaisir dans les frontières chrétiennes hétérosexuelles. Ainsi, son corps, qui devient performant et palimpseste, se présente comme une allégorie de ses dépaysements, car il est plein de cicatrices, de chirurgies et finit enfermé dans une prison. À partir de cette appréhension archiviste du corps, on verra que les transsexuelles immigrées se trouvent deux fois déplacées : lorsqu’elles décident de remodeler, de reconstruire et de réarranger leur corps, elles troublent les archives sexuelles et nationales légitimées par la société traditionnelle.
Une femme dépaysée. Dove mi trovo de Jhumpa Lahiri
Authors: De Balsi Sara 
Published: December 2023

Dans Dove mi trovo (Guanda, 2018), premier roman en italien de l’écrivaine américaine Jhumpa Lahiri, déjà autrice d’une autobiographie translingue au titre parlant (In altre parole, Guanda 2014 / En d’autres mots, traduction française publiée par Actes Sud en 2015), une femme dont ne sont donnés ni le prénom ni la nationalité, évolue dans une ville non précisée d’Italie. Seule, sans enfants, âgée d’une quarantaine d’années, elle vit dans un appartement qui ne lui appartient pas. Au cours du roman, pour son travail de chercheuse, elle est amenée à participer à une conférence où elle croise un homme âgé, étranger, important philosophe. Peu de temps plus tard, elle apprendra son décès en lisant le journal. Mon hypothèse – aussi indémontrable que fascinante – est que le philosophe que la narratrice rencontre est inspiré de la figure de Tzvetan Todorov, disparu en février 2017, plus ou moins dans la période où Lahiri écrivait son roman ; plus précisément, il serait celui que la critique a appelé le « second Todorov », l’auteur, notamment, de l’autobiographie intellectuelle L’Homme dépaysé (Seuil, 1996). Dans cet essai, Todorov envisage autobiographiquement le dépaysement comme une expérience – éminemment individuelle – de décentrement, d’étonnement et de désorientation, qui lui a apporté de nombreuses découvertes et enseigné l’art de la curiosité et un certain relativisme culturel. Je formule donc l’hypothèse que Lahiri a lu le « second Todorov » et a fait sienne cette conception, allant jusqu’à (peut-être) insérer dans le roman un petit hommage au philosophe. Dans cette contribution, après avoir présenté brièvement la conception todorovienne de dépaysement, je propose une lecture du roman Dove mi trovo à la lumière de celle-ci.
Traduire le dépaysement : comment recréer le Riddleyspeak de Russell Hoban en français ?
Authors: Buhl Virginie 
Published: December 2023

Dans Riddley Walker de Russell Hoban, le dépaysement procède à la fois du linguistique, du cognitif, de la narrativité et du fictionnel. Ce roman expérimental propose une expérience de lecture qui déclenche une immersion dépaysante dans un autre espace-temps. L’intrigue se situe dans une Angleterre post-apocalyptique défigurée par une explosion atomique. La topographie de la région dans laquelle se déroule l’action ne ressemble plus que vaguement au Kent et tous les noms de lieux semblent, à la première lecture, à la foi inconnus et étrangement familiers. Cette perte des repères cognitifs habituels constitue une invitation au voyage et lance la personne qui lit dans un jeu de pistes puisque la narration et le style sont également vecteurs de dépaysement : le narrateur homodiégétique est Riddley Walker, un jeune garçon de 12 ans. Comme son nom l’indique, il promène ses lecteurs au gré d’un récit inabouti qui obéit à sa logique propre et il s’exprime dans une langue étrange, énigmatique et fortement marquée par l’oralité : le Riddleyspeak. Cette langue transfigure la réalité et défamiliarise le lecteur qui, forcé de lire autrement, perd momentanément ses automatismes. L’écriture de la version française de ce roman – l’opération par laquelle le texte source a été transplanté dans une nouvelle langue-culture – a constitué en soi une nouvelle aventure placée sous le signe du dépaysement pour le traducteur. Nicolas Richard a dû s’approprier le Riddleyspeak pour créer une nouvelle langue, le Parlénigm qu’il s’agissait de parler couramment, comme une langue étrangère.