bluuebunny/crossref_metadata_2025_split huggingface dataset:
Trampoline Park Injury Trends
Authors: Teague Warwick J. , Dipnall Joanna F. , Palmer Cameron S. , Beck Ben 
Published: December 2023

OBJECTIVES
Trampolines are an important cause of childhood injury and focus of injury prevention. Understanding and prevention of trampoline park injury is constrained by inadequate exposure data to estimate the at-risk population. This study aimed to measure trampoline park injury incidence and time trends using industry data.

METHODS
Cross-sectional study to retrospectively analyze reported injuries and exposure in 18 trampoline parks operating in Australia and the Middle East, from 2017 to 2019. Exposure was derived from ticket sales and expressed as jumper hours. Exposure-adjusted incidence was measured using marginalized 0-inflated Poisson modeling and time trends using Joinpoint regression.

RESULTS
There were 13 256 injured trampoline park users reported from 8 387 178 jumper hours; 11% sustained significant injury. Overall, trampoline park injuries occurred at a rate of 1.14 injuries per 1000 jumper hours (95% confidence intervals 1.00 to 1.28), with rates highest for high-performance (2.11/1000 jumper hours, 1.66 to 2.56) and inflatable bag or foam pit (1.91/1000 jumper hours, 1.35 to 2.50) jumping. Significant injuries occurred at a rate of 0.11 injuries per 1000 jumper hours (0.10 to 0.13), with rates highest for high-performance (0.29/1000 jumper hours, 0.23 to 0.36), and parkour (0.22/1000 jumper hours, 0.15 to 0.28) jumping. Overall, injury rates decreased by 0.72%/month (−1.05 to −0.40) over the study period.

CONCLUSIONS
Trampoline park injuries occur in important numbers with sometimes serious consequences. However, within these safety standard-compliant parks, exposure-adjusted estimates show injuries to be uncommon and injury rates to be declining. Further reductions are required, especially severe injuries, and this study can enhance injury prevention initiatives.
Ejercicios Físicos Combinados Con La Crioterapia: Una Alternativa De Tratamiento Para La Gonoartrosis
Authors: Cedeño Martínez Manuel Enrique , Pérez Fonseca Iliana Damaris 
Published: December 2023

La investigación se desarrolla en la comunidad Camilo Cienfuegos, con el objetivo de lograr una mayor eficacia en la rehabilitación de las personas diagnosticadas con gonoartrosis de rodilla. Se realiza un estudio, en 60 pacientes con el diagnóstico de Gonoartrosis de rodilla sin criterio quirúrgico que acuden a la Consulta de Fisiatría del Policlínico Bayamo Oeste del municipio Bayamo, Granma, remitidos por los médicos especialistas en Ortopedia y Reumatología en el período comprendido entre enero de 2008 a enero de 2009. Los pacientes fueron asignados mediante una tabla de asignación aleatoria a dos grupos de tratamiento: Experimental y Control, con 30 cada uno. El grupo experimental recibe tratamiento con Ejercicios Físicos Terapéuticos combinados con Crioterapia y el grupo Control recibe un tipo de tratamiento convencional de rehabilitación. Los datos se recogieron en una planilla de recolección de datos y se empleó la prueba Chi Cuadrado (X2c) para verificar el comportamiento entre ambos grupos respecto a las variables objeto de estudio; además de la prueba de diferencia de proporciones para determinar el comportamiento de la amplitud de movimiento articular referente a la flexión y la extensión. Se trabajó con un nivel de significación =0,05; lo que permitió arribar a la conclusión de que la aplicación de los Ejercicios Físicos Terapéuticos combinados con la crioterapia logran desaparecer el dolor, alcanzar la máxima amplitud de movimiento articular y la capacidad funcional muscular con un menor número de sesiones sin la aparición de eventos adversos en la rehabilitación del paciente con Gonoartrosis de rodilla.
Primary osteoarthritis of the lumbar spine presenting as chronic low back pain or sciatica or both (prolapsed lumber disc syndrome): establishing its cause, pathogenesis, and treatment: A randomized case-control study
Authors: Agrawal R C 
Published: December 2023

: The objectives of this study were to compare three scores, Western Ontario McMaster Universities Osteoarthritis Index (WOMAC), Oswestry Disability Index (ODI) for low back pain, and Visual Analogue Scale (VAS) Vertical Version at the beginning and end point in two, Trial (G1), and Control (G2) groups of Primary Osteoarthritis of lumbar spine patients.The inner nucleus pulposus may rupture out from the annulus as the disc continues to degrade or as the spine continues to be stressed. This is a herniated or burst disc. The nerve roots that are immediately behind the disc space may then be pressed by the disc material fragments. This may result in discomfort, frailty, numbness, or alterations in feeling.: Understanding the causes, pathophysiology, and treatments for prolapsed lumber disc syndrome, which presents as primary osteoarthritis of the lumbar spine and causes chronic low back pain, sciatica, or both.: In this study, the total number of patients were 150, in G1 - 100, and G2 - 50. G1 received the hypothesized treatment, Contracture Correction Therapy (CCT), while G2 did “No Therapy”. WOMAC determination was done by the questionnaire; ODI by modified Oswestry Low Back pain disability questionnaire and VAS by Visual Analogue Scale Vertical Version, all at 0, 6, 12, and 24 weeks. The CCT consisted of 1. Immobilization of the spine. 2. Passive and active extension of the spine. 3. Three therapeutic rituals and 4. Advice to avoid stooping.: The CCT receiving was associated with much recovery (P &#60;0.00) while non-receiving with much less (P =0.00). In G1 WOMAC decreased from 54.29 to 0.00; ODI from 51.82 to 1.80; VAS rose from 37.56 to 100 (rise indicates betterment) P= 0.00. In G2 WOMAC lowered from 56.40 to 4.08; ODI from 65.10 to 6.0; VAS rose from 34.40 to 81.00. Relief in symptoms was similar.: The cause, pathogenesis, and treatment are deficient full extension, I.V. joint capsule contracture formation, and extension of the lumbar spine respectively.
Medical education in the time of pandemic — undergraduate medical students’ perspectives after a year of online education during COVID-19 pandemic in central India
Authors: Ajitkumar Deepa , Khandelwal Rekha R , Jain Kamlesh , Gupta Madhur 
Published: December 2023

Beginning in 2019, the pandemic hampered the pedagogical process in a way unprecedented in history, as a result modern technological advances took centre stage and medical colleges introduced e-classes to continue their academic activities. To study the undergraduate medical students' perspectives towards online medical education programs during the COVID -19 pandemic. A descriptive cross-sectional research was conducted in which MBBS students who had undergone one year of online classes from four different medical colleges of central India. Participated students were administered a validated questionnaire consisting of 24 questions through Google forms. The data of 426 undergraduate medical students across four medical colleges in Central India was analysed. The percentage of male and female students were 52.8 and 47.2 respectively and the majority who attended online classes lived in urban areas (68.1%). Learning during the pandemic was heavily dependent on online classes (77.7%), which were accessed through smartphones (80%). There was a significant difference seen in time spent on digital education (p&#60;0.001). Upon analysing the teaching methods, live tutorials (48.8%) and video tutorials (50.4%) scored high. The benefits of online education were its flexibility regarding time and pace of learning whereas internet connectivity and lack of interaction were its greatest disadvantagesThough introduced only as a stopgap arrangement to tide over the present crisis, technology enhanced learning is here to stay especially with advent of e-health platforms and teleconsultation.
Investigating the effectiveness of blended learning in English foreign language classroom
Authors: Benghalem Boualem 
Published: December 2023

The COVID-19 pandemic has forced educational institutions worldwide to explore new learning modes, including blended learning, which combines face-to-face instruction with online learning. Despite the potential benefits of blended learning, its effectiveness is influenced by several factors that can pose challenges, particularly in terms of student outcomes. This study aimed to investigate the attitudes of third-year English students toward blended learning. A total of 45 students completed an online questionnaire, and three teachers participated in interviews. Results indicated that students had mixed attitudes towards blended learning and generally preferred face-to-face instruction over online learning. Additionally, the study found that while some teachers expressed negative attitudes toward blended learning, others recognized its potential effectiveness and importance. These results highlight the need for educators to consider the challenges and advantages of blended learning and provide appropriate support and resources to help students adapt to this new mode of learning.
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Keywords: Attitude; blended Learning; Covid-19; E-learning; face-to-face instruction; learning English.
Investigating the Need for the Development of Mathematics Physics E-Modules for Students
Authors: Astalini Astalini , Darmaji Darmaji , Kurniawan Dwi Agus , Citra Yulita Dwi 
Published: December 2023

This research is motivated by the difficulties of students in studying Mathematics Physics II with fourier series material because the main source books used are all in English. Students also admitted that the difficulty in studying Mathematics Physics II was due to the lack of variety of examples. In addition, it is also known that the development of e-modules for the Physics Mathematics II course has never been done before. Therefore, the researchers conducted this investigation with the aim of knowing how much students need for the development of e-modules for the Fourier series material in the Mathematics Physics II course. The method used in this study is a mixed method (mixed method). Data was collected using a questionnaire sheet and student interviews. The data obtained in the form of quantitative data and qualitative data. Quantitative data was analyzed by descriptive statistical analysis test, while qualitative data was analyzed using the Miles & Huberman approach. Through the results of this study, it was found that most of the students expressed their need for the development of the e-module in Mathematics Physics II for fourier series material. The novelty of this study is that the material used is Fourier series material which has never been studied by previous research.

Key words: Education, E-module, Investigation, Mathematics, Physics
Long-Term Effect of VR-based Brain-Computer Interfaces Training in Brain Activity and Clinical Outcome: A Study with Chronic Stroke Patients
Authors: Vourvopoulos Athanasios , Fleury Mathis , Blanco-Mora Diego , Fernandes Jean-Claude , Figueiredo Patrícia , Badia Sergi Bermúdez i 
Published: December 2023

Abstract
Restorative Brain-Computer Interfaces (BCIs) can provide an alternative non-muscular channel for stroke patients who lack volitional movement by reinforcing the modulation of sensorimotor rhythms through motor-imagery (MI). MI practice can be augmented through embodied proprioceptive feedback delivered by virtual reality (VR).
Nonetheless, detailed information concerning the impact of embodied VR-BCI training in clinical outcome is still largely missing.
This paper investigates the long-term effect of VR-BCI training in brain activity patterns measured through electroencephalography (EEG), functional magnetic resonance imaging (fMRI) and clinical scales through the Fugl-Meyer Assessment (FMA) pre-, post- intervention.
Four chronic stroke patients underwent a 3-week MI-BCI longitudinal intervention, performing a bimanual rowing task (NeuRow) in VR involving MI and motor observation. From the EEG, the Event-related Desynchronization (ERD) and lateralization indices were extracted from the Mu band (8-12 Hz), and from the MR imaging, the activation from the primary motor (M1) and supplementary motor (SMA) regions of interest (ROIs) was analyzed during MI. Finally, the BCI performance was computed from the BCI training session.
Results show that all patients induced significantly the Mu ERD power, however, the affected side showed reduced ERD compared to baseline during the contralateral MI. Significant ERD differences originating from both the lesioned and the healthy hemisphere were found when comparing post- with pre- intervention in all patients, and decreasing ERD was found for patients with no clinical improvement. Patients with decreased lateralization of ERD had no improvement of the FMA score. Activity within ipsilesional M1 and SMA is correlated with the FMA score. Overall, current results show that stroke patients in the chronic phase can modulate their brain activity patterns using MI in an embodied VR-BCI task, with specific patient differences between brain activity and clinical outcome. Nonetheless, only patients with increased ERD lateralization showed clinical improvement.
DEAr – Differential Expression Analyzer
Authors: Karpenko Dmitriy 
Published: December 2023

Abstract
Genes expressions are key features of cells and tissues studied in laboratories and clinics. Before analyzing expression data, normalization must be performed. Normalization methods can be generalized to the idea of forming a baseline from a subset of stable genes and then representing gene expressions as differences from this baseline. There are solutions available to help verify that the genes provided are stable enough to be used as a reference. Such a strategy works for high-throughput sequencing, but in cases of real-time PCR we have to work with a limited number of genes and especially when we compare with data from previous experiments. In such cases, we may struggle to find genes that are stable for the required cells and conditions. Here, I present a software that simultaneously checks expressions of all genes in the dataset and selects the most stable as a baseline for the less stable, using weighted calculations for normalization corrections. The Differential Expression Analyzer (DEAr) assigns weights to all values depending on accuracy of direct measurements and reproducibility of differential expressions in the dataset, at the same time the program utilizes provided external knowledge about stability or instability of genes in considered materials and contributes it to weights as well. The important improvement is that the original algorithm allows individual weight to be assigned to each gene expression value for each sample to perform normalization corrections. It allows DEAr to work without input for possible missing values. The algorithm is based on recursive computations that are described in detail in the article. The program is packaged in an executable file for the OS Windows. DEAr accepts and returns data in Excel format, so no programming skills are required for fast, automated analysis of differential expression.
Ultrasonography-Based Localization of Intraparotid Lymph Nodes: Retrospective Study in Patients Without Systemic Disorders
Authors: BALKAN Elif POLAT , İNCEBEYAZ Burak , DENİZ Hatice Ahsen , DELANTONİ Antigoni , ORHAN Kaan 
Published: December 2023

Abstract
Background The challenge for surgeons arises in cases of parotid metastasis, particularly when dealing with deep masses that involve the upper branches of the facial nerve. This study aims to determine the distribution of intraglandular lymph nodes in the parotid gland relative to the facial nerve utilizing ultrasonography.
Methods Two distinct USG devices were employed in two separate centers for this study: Siemens Acuson S2000 USG scanner with a linear probe of 4-9 MHz and a high-frequency linear probe of 5.5-18 MHz, and GE Logiq S8 USG scanner with a linear probe of 9 MHz and a high-frequency linear probe of 12 MHz. The study analyzed 330 USG images where the probe was held longitudinally to visualise the parotid gland. The group achieved a consensus on all images.
Results The locations with the highest concentration of lymph nodes were 1A (21.5%) and 2A (21.5%), whereas 2A-B (4.2%) exhibited the fewest lymph nodes. Males demonstrated a statistically significantly higher incidence of lymph nodes than females. Furthermore, the study identified a statistically significant correlation between age and the location of lymph nodes. The analysis of two different populations in this study revealed statistically significant differences in the location of most lymph nodes.
Conclusions The findings hold potential significance for the early diagnosis of parotid gland metastases from head and neck pathologies, utilizing USG as a cost-effective, rapid, and non-invasive imaging modality. Additionally, this information may aid in preventing damage to the facial nerve during surgical interventions.
Real-World Impact of Bridging Therapy on Outcomes of Ide-cel for Myeloma in the U.S. Myeloma Immunotherapy Consortium
Authors: Afrough Aimaz , Hashmi Hamza , Hansen Doris , Sidana Surbhi , Ahn Chul , Peres Lauren , Dima Danai , Freeman Ciara , Puglianini Omar Castaneda , Kocoglu Mehmet , Atrash Shebli , Voorhees Peter , Shune Leyla , McGuirk Joseph , Simmons Gary , Sborov Douglas , Davis James , Kaur Gurbakash , Sannareddy Aishwarya , Ferreri Christopher , Gaballa Mahmoud , Janakiram Murali , nadeem omar , Midha Shonali , Wagner Charlotte , Locke Frederick , Patel Krina , Khouri Jack , Anderson Larry , Lin Yi 
Published: December 2023

Abstract
In a retrospective analysis at 11 US medical centers, bridging therapy (BT) impact after receiving idecabtagene vicleucel was assessed in 214 patients. 79% received BT, including 12% Selinexor-containing, 45% alkylator-based, 15% proteasome inhibitor combinations, and 18% immunomodulatory drugs +/- monoclonal antibody combinations (IMiD +/- mAb combos). BT recipients had worse performance status, higher stage disease, ferritin and CRP pre-infusion. The overall response rate to BT was 12%, with no difference among BT subgroups. Safety profiles were similar, but Selinexor had a higher grade ≥2 ICANS incidence. Median progression-free survival (PFS) was 6.7 months in BT vs. 11.5 months in no-BT (p=0.007). Median PFS was longest with IMiD +/- mAb combos (12 months), comparable to no-BT, and significantly longer than other BT subgroups (p=0.01). Alkylator-based BT had inferior PFS compared to IMiD +/- mAb combos (p=0.03). Median overall survival (OS) for the BT was 13.8 months vs. not reached in no-BT (p=0.002). Alkylator-based BT had shorter OS compared to others (11.97 months vs. NR; p=0.001). Stepwise Cox regression showed alkylator-based BT and response
Kirigami-Inspired, Three-Dimensional Piezoelectric Pressure Sensors Assembled by Compressive Buckling
Authors: Liu Changbo , Zhang Yi , Jia Ben , Ma Dongqin , Tian Xuecheng , Cui Yuanyuan , Deng Yuan 
Published: December 2023

Abstract
Piezoelectric sensors whose sensing performances can be flexibly regulated hold significant promise for efficient signal-acquisition applications in the healthcare field. The existing methods for regulating the properties of polyvinylidene fluoride (PVDF) films mainly include material modification and structural design. Compared to material modification, which has a long test period and an unstable preparation process, structural design is a more efficient method. The Kirigami structure combined with compressive buckling can endow the flexible film with rich macrostructural features. Here, a method is fabricated to modulate the sensing performance by employing distinct 3D structures and encapsulation materials with varying Young’s moduli. The relationship among the aspect ratio (α), pattern factor (η), elastic modulus of encapsulation materials, and equivalent stiffness is obtained by finite element simulation, which provides theoretical guidance for the design of the 2D precursor and the selection of encapsulation materials. In the demonstration applications, the sensor accurately captures pulse waveforms in multiple parts of the human body and is employed for the pressure monitoring of different parts of the sole under various posture states. This method of structure design is efficient, and the preparation process is convenient, providing a new strategy for the performance control of piezoelectric pressure sensors.
The prevalence and distribution characteristics of anxiety disorders, social support, and quality of life in the population many years after the lushan earthquake in Ya’an, China
Authors: Xu Liu-Xiu , Liu Shan , Zhang Bing-Zhi , Wu Jun-Lin , He ZHao-Xia , Lu Yu-Tong , Bai Jing-Zhen , Ran Mao-Sheng , Gao Ru 
Published: December 2023

Abstract
Purpose To explore (1) the anxiety disorders prevalence, relevant infuencing factors of anxiety disorders; and (2) the current status of social support and quality of life of people with anxiety disorders in the affected areas many years after Lushan earthquake in Ya’an, China.Methods An epidemiological mental health survey was conducted to identify the prevalence of anxiety disorders in general peoples in Ya’an.A multi-stage, group-matching random sampling method was adopted.By face-to-face interviewed,firt stage used the scale for preliminary screening by traned psychiatric nurses,and the second stage used the 5th edition of the Diagnostic and Statistical Manual of Mental Disorders (DSM-V) for diagnosis by trained Psychiatrists.Results There were 8876 valid questionnaires.The adjusted 12-month and lifetime prevalence of anxiety disorder was 3.83% and 4.44%,respectively.The total scores of SSRS and SF-36 in patients with anxiety disorder were lower than others(all P < 0.05). Regression analysis showed that being female, middle or old, and with chronic physical diseases were risk factors for anxiety disorder, and minority ethnicity, higher education level, and middle or high income were protective factors.Conclusion Though after many years of Lushan earthquake, we also should pay more attention the people of th female, middle or old, with lower education level, lower income level, and chronic physical diseases.
Development of a model system to study the regulation of patterning competency in regenerating axolotl limbs
Authors: Raymond Michael , Vieira Warren , Manon Sheyla , Cherubino Matthew , McCusker Catherine 
Published: December 2023

Abstract
Limb regeneration in the Mexican axolotl requires the dedifferentiation of mature limb cells into progenitor cells known as blastema cells. The blastema cells become competent to the signals that inform the blueprint, or pattern, of the regenerating cells to organize into the complex limb structures. Signaling downstream of the limb nerves plays a role in the induction of patterning competency; however, the underpinnings of this process are poorly understood. Studying patterning competency in amputated axolotl limbs is challenging because the complex network of signals and tissue interactions that occur during regeneration are activated. Here, we address this issue by developing an assay that we call the competency accessory limb model (CALM) assay, which is based on a simplified limb injury model where various signaling inputs can be systemically added and their individual contributions to patterning competency can be evaluated independently. We used the CALM as a platform to generate foundational knowledge by characterizing the specific timing of competency induction and maintenance and identifying nerve-dependent signals sufficient for induction and epigenetic modifications induced in wounded cells by these signals.