bluuebunny/crossref_metadata_2025_split huggingface dataset:
مدلول " ليْس بشيء " عند الإمام النسائي
Authors: Alitfy Ahmed Eid Ahmed 
Published: December 2023

In this study, I dealt with the term “nothing” according to Imam al-Nasa’i, collected and studied, and I followed the inductive, critical, and analytical approach, by identifying the narrators whom Imam al-Nasa’i said, “Nothing,” and comparing his words with those of critics and analyzing them, and then came to a ruling It is clear in it after the critical study of each narrator, who numbered twelve narrators, in order to remove the confusion that occurred in the understanding of what is meant by it, and it was exposed, in it, to a brief translation of the imam, and showed the meaning of this term, through the interpretation of the imams after him, with comparison with the words of critics in The narrator, and it was found that al-Nasa’i - may God have mercy on him - was one of the hard-liners in al-jarh and al-ta’deel. The research concluded with the most important results, including: that Imam al-Nasa’i - may God Almighty have mercy on him - is considered one of the hard-liners in the wound and the modification, and that the narrator when it is proven that he is seized before his speech, and he is not harmed by what he erred in as long as he is not obscene in it, and he has the favor of the imams, and God knows best.
Mitigation of Sexual Harassment Based on The Yellow Book Study in Islamic Boarding Schools
Authors: Nur Muhammad , Najib Ariz , Wahyuni Fitri , Rizky Mustikasari Bella , Silvia Rahayu Ajeng , Muflihatusyawal Edfitri 
Published: December 2023

AbstractOvercoming the moral decline that is currently sweeping the Indonesian nation, Islamic boarding schools have a large role in the world of education. The sad thing is that there are many cases of sexual harassment in educational settings and even in Islamic boarding schools. Whereas pesantren should be an ideal place to form character, not only through intellectual intelligence but also expect emotional and spiritual intelligence so that noble character is realized. This study uses the narrative review approach and aims to identify whether learning the yellow book related to sexual education has implications for mitigating sexual harassment in Islamic boarding schools. The results of the study then showed that the yellow book was able to eradicate the rampant sexual harassment, especially that which occurred in Islamic boarding schools. Therefore, the teachings of the yellow book should be studied, deepened, and implemented in real life, so that sexual harassment in Islamic boarding schools can be minimized or even completely absent. Keywords: sexual harassment, yellow book, Islamic boarding school
Variation in carrying angle - A normative study
Authors: Khan Mohammed Shadab , Singh Rakesh B 
Published: December 2023

The synovial joint that comprises the elbow is a hinge joint with a single degree of freedom, allowing for flexion and extension movements. The primary objective of this study was to investigate the varying carrying angles that were observed. An observational study was conducted in the Department of Orthopaedics Heritage Institute of medical sciences Varanasi. Around 500 samples were taken for a period of 2 years. All patients of both genders inclusive of age group 8 to 19 years were taken with their consent. Asymptomatic individuals without any deformity, fractures, anomalies and previous history of surgery around elbow were included. All with previous elbow injuries and anomalies around elbow, history of Endocrine disorders, athletes and deformity occurring after any elbow injury were excluded.The present study was conducted in the Department of Orthopaedics, Heritage Institute of Medical Sciences, Varanasi with the objective to observe the physiological factors responsible for the change in the carrying angle in normal individuals in a tabulated manner. A total of 500 patients were included in the study. There was no significant (p&#62;0.05) difference in carrying angle between male and females among different age groups. There was no significant (p&#62;0.05) difference in carrying angle between male and females among different height groups. Only age was positively significantly (r=0.48, p=0.001) correlated with carrying angle.Females had a considerably higher carrying angle (12.96±2.44) than males (12.19±1.74) (p=0.001). There was no significant difference in carrying angle across height groups or genders (p&#62;0.05). Age correlated positively with carrying angle (r=0.48, p=0.001).
Nauka języka polskiego poprzez działania projektowe (na podstawie projektu „Polskie Cztery Pory Roku w Charkowie”)
Authors: Butko Sofiia , Gębka-Wolak Małgorzata 
Published: December 2023

W artykule zostały zaprezentowane koncepcja i zadania zrealizowane w ramach projektu dydaktyczno-naukowego „Polskie cztery pory roku w Charkowie. Spotkania z polską kulturą, językiem i historią”. W projekcie wykorzystano podejście zadaniowe w zakresie rozwijania kompetencji komunikacyjnych i społeczno-kulturowych odbiorców ukraińskojęzycznych. Podejście to sprawdziło się szczególnie podczas realizacji etapu „Lato z Kopernikiem” (szkoła letnia języka i kultury polskiej). W artykule opisano działania realizowane w trakcie szkoły letniej, które ze względu na cel, formy i sposoby porozumiewania się w języku polskim zostały podzielone na trzy typy: w zakresie dydaktycznym, prywatnego życia codziennego i życia towarzyskiego. Szczególną uwagę poświęcono analizie projektu studencko-lektorskiego, który w pełni realizował zasady podejścia zadaniowego w nauczaniu języka polskiego jako obcego. Artykuł zawiera opis etapów wykonania tego zadania oraz otrzymanego produktu – podręcznika do nauki języka polskiego jako obcego dla odbiorców ukraińskojęzycznych pt. „Miasto i jego mieszkańcy”.
ARGUIÇÃO EPIDEMIOLÓGICA DA PREVALÊNCIA DOS CASOS DE OSTEOMIELITE NO BRASIL DE 2013 A 2022
Authors: Cassimiro Catalão de Albuquerque Matheus , Leonidas da Silva Paloma , Alves da Silva Madson , Benicio Bossler Caroline , Rangearo Peres Carlos Alberto 
Published: December 2023

Introdução: A osteomielite é um processo inflamatório de origem infecciosa no osso que pode ocorrer em qualquer parte óssea do corpo. É uma condição relativamente rara, mas pode ser extremamente perigosa se não for diagnosticada e tratada precocemente. Existem diferentes formas de osteomielite, sendo a forma aguda e a forma crônica as mais comuns Metodologia: Trata-se de um estudo epidemiológico descritivo, realizado por meio da coleta de dados anuais referentes ao período entre 2013 até 2022, no Brasil, disponibilizado pelo Sistema de Informação de Agravos de Notificação (SINAN) Resultados: Identificou-se um total de 147.969 casos confirmados, com maior incidência em homens e pessoas na faixa etária de 40 a 49 anos. O Sudeste foi a região com mais notificações. Conclusão: Osteomielite é uma infecção que afeta o osso e a medula óssea. É uma condição relativamente rara, porém grave, portanto, é fundamental estar atento aos sintomas da osteomielite e buscar atendimento medico
Palavras-chave: Osteomielite. Infecção. Epidemiologia. Inflamação
ANÁLISE DO PERFIL EPIDEMIOLÓGICO DOS CASOS DE CATARATA NO BRASIL DE 2018 A 2022
Authors: Gomes Ferreira Filho Marcio Adriano , Fernandes de Morais Neto Joaquim , Silva Luz Josué Júnior , Coelho da Silva Cruz Sabryna , De Carvalho Leite Noely , De Santana Costa Danillo 
Published: December 2023

INTRODUÇÃO: A catarata trata-se de uma opacificação do cristalino que causa cegueira parcial ou total. Ocorre principalmente em decorrência do envelhecimento, porém, existem casos de catarata congênita (de nascença) ou provocada por fatores como exposição demasiada ao sol sem óculos apropriados OBJETIVOS: Esse artigo tem como intuito fazer uma análise do perfil epidemiológico dessa patologia no Brasil no período de 2018 a 2022 MÉTODO: Trata-se de um estudo epidemiológico de natureza descritiva, realizado por meio da coleta de dados anuais referentes ao período entre 2018 até 2022, no Brasil, disponibilizado pelo Sistema de Informações Hospitalares (SIH). As informações coletadas foram do número total de casos de catarata no país. RESULTADOS: Registrou-se um total de 270878 casos de catarata, sendo que idosos (60 anos ou mais) foram os mais acometidos e quanto ao sexo as mulheres. Em se tratando das regiões e estados do Brasil, o Sudeste e a cidade de São Paulo tiveram o maior número de notificações CONCLUSÕES: A catarata é um problema sério que afeta uma grande quantidade de pessoas no Brasil e mundialmente. Sendo assim, é fundamental o diagnóstico precoce da patologia por meio de consultas periódicas com um profissional de saúde especializado
PALAVRAS-CHAVE: Catarata. Patologia. Visão. Epidemiologia
Lower uric acid and adequate hydration are associated with lower risk of febrile neutropenia following autologous bone marrow transplantation in patients with lymphoma
Authors: Nejati Babak , Kourehpaz Zohreh , Dolatkhah Roya , Varshochi Mojtaba , Farmani Maryam , Parviz Alireza 
Published: December 2023

Background. Despite the promising results of autologous bone marrow transplantation (BMT) in patients with lymphoma, infectious complications limit its positive outcomes. This study evaluated the incidence and associated factors of febrile neutropenia (FN) following BMT in patients with lymphoma.
Materials and methods. The study consecutively included 147 patients with lymphoma who were candidates for BMT. Clinical and laboratory results were recorded, and after BMT, the occurrence of FN was investigated through the daily evaluation of neutrophil count and body temperature.
Results. On average, FN occurred in 91 patients (61.9%) after 12.77 ± 2.45 days after BMT. Lower fluid balance was associated with a higher risk of FN (lowest adjusted odds ratio [OR] at day -2 = 0.602, 95% confidence interval [CI] = 0.299 – 0.870, p-value = 0.007). The higher uric acid level was associated with a higher risk of FN (highest adjusted OR at day -10 = 1.617, 95% CI = 1.328 – 1.963, p-value = 0.035). LDH was also positively correlated with FN (highest adjusted OR at day 0 = 1.501, 95% CI = 1.198 – 2.104, p-value = 0.004).
Conclusions. Adequate hydration of the patients is of paramount importance for preventing FN in patients who receive BMT. Furthermore, uric acid and LDH could be considered in future studies for the risk stratification of FN.
Return to Daily Activities, Work, and Sports at 3 Months After Total Hip Arthroplasty
Authors: Peters Maud C.W.M. , Pronk Yvette , Brinkman Justus-Martijn 
Published: December 2023

Background:
It is largely unknown if and when patients return to daily activities after undergoing total hip arthroplasty (THA) and which factors might influence this return. This study aimed to assess the percentages of patients who had been able to return to daily activities, work, and sports at 3 months after THA. Furthermore, the time to return and factors influencing the return (patient characteristics, surgical characteristics, and preoperative patient-reported outcomes) were assessed.

Methods:
A retrospective cohort study of patients who underwent THA was performed with use of prospectively collected data. At 3 months postoperatively, patients completed a questionnaire regarding their return to 16 different activities across the categories of daily activities, work, and sports. The percentage of patients who returned to an activity, the time to return, and factors influencing the return were analyzed with use of logistic regression models utilizing backward selection.

Results:
A total of 2,006 patients were studied. Most of the studied activities had been returned to by the majority of patients at 3 months after THA, with the percentage of patients who returned to an activity ranging from 28.8% to 97.9%. The mean or median time to return to an activity ranged from 1 to 56 days after THA. For 13 out of 16 activities, 1 or more of the studied factors influenced the return to the activity. R2 values ranged from 0.057 to 0.273.

Conclusions:
At 3 months after THA, 8 out of 10 patients had returned to daily activities, 7 out of 10 had returned to work, and 5 out of 10 had returned to sports. Factors that clearly influenced the return to daily activities, work, and sports could not be established. These findings might be useful in setting realistic expectations when counselling patients on their return to daily activities, work, and sports after THA.

Level of Evidence:
Therapeutic Level III. See Instructions for Authors for a complete description of levels of evidence.
New Benchmarks on Protocol Amendment Experience in Oncology Clinical Trials
Authors: Botto Emily , Smith Zachary , Getz Kenneth 
Published: December 2023

Abstract
Background The drug development industry’s focus on cancer-related treatments continues to rise; however, narrow patient populations and complex procedures have increased the complexity of oncology protocols at an accelerated rate compared to non-oncology drugs. Tufts Center for the Study of Drug Development utilized data from a study investigating the impact of protocol amendments to compare how oncology clinical trials differ from non-oncology and identify opportunities to optimize performance in oncology clinical trials.Methods Sixteen drug development industry companies contributed data from 950 protocols and 2,188 amendments to a study conducted in 2022 investigating protocol amendments. Analysis compared differences in amendment impact and causes between 249 oncology and 701 non-oncology protocols.Results Compared to non-oncology, oncology protocols had a significantly higher prevalence (72.1% and 91.1%, respectively) and number (3.0 and 4.0, respectively) of protocol amendments. Oncology protocols with amendments had significantly lower participant completion rates compared to oncology protocols without amendments, while no significant differences were found among non-oncology. During the COVID-19 pandemic, the study found an increased number of substantial amendments, lower completion rates, and higher dropout rates among oncology protocols compared to before the pandemic.Conclusions Efforts to prevent avoidable protocol amendments in the industry have not been effective in oncology, where increasingly complex designs are reflected in difficult to predict cycle times, barriers to recruitment and retention and an increase in protocol amendments.
CAF-related miR-642a-3p supports the migration, invasion, and EMT of hepatocellular carcinoma by targeting SERPINE1
Authors: Zhang Shuo , Cao Gang , Shen Shuijie , Wu Yu , Tan Xiying , Jiang Xiaoyan 
Published: December 2023

Abstract
Hepatocellular carcinoma (HCC) is one of the most deadly malignancies. Due to the late detection of HCC, the treatment are not satisfactory, accompanied by poor prognosis. Therefore, early detection has important value for HCC treatment. MicroRNAs (miRNAs), the intercellular communication in the tumor microenvironment, are widely accepted as molecular markers of HCC. However, there are few studies on miRNAs involved in the crosstalk between cancer-associated fibroblast (CAF) and HCC cells. In the study, transcriptome sequencing, siRNA, co-culture, reverse transcription quantitative real-time PCR (RT-qPCR), western blot, dual-luciferase reporter system, and xenograft tumor model, were used to explore the role of miR-642a-3p/SERPINE1 axis in HCC progression. The results showed that in co-culture with CAF, the expression of SERPINE1 mRNA decreased, whereas miR-642a-3p expression increased in Huh7 cells. SERPINE1 knockdown significantly enhanced the invasion ability and increased miR-642a-3p expression in Huh7 cells. Dual-luciferase reporter assay discovered that miR-642a-3p had a binding effect with SERPINE1, suggesting that SERPINE1 was a target of miR-642a-3p. In addition, miR-642a-3p mimics inhibited SERPINE1 expression and promoted the migration, invasion, and EMT of Huh7 cells, whereas miR-642a-3p inhibitor had the opposite effect. More importantly, miR-642a-3p knockdown inhibited the proliferation and spread of xenograft tumors in the liver. miR-642a-3p knockdown significantly inhibited epithelial-mesenchymal transition (EMT) in the liver. These findings reveal that the miR-642a-3p/SERPINE1 axis plays an important role in the invasion and metastasis of HCC, and can be used as a novel therapeutic target for HCC.
Tracking magma pathways and surface faulting in the Southwest Rift Zone and the Koaʻe fault system (Kīlauea volcano) using photogrammetry and structural observations
Authors: Mannini Stefano , Ruch Joël , Hazlett Richard W. , Downs Drew T. , Parcheta Carolyn E. , Lundblad Steven P. , Anderson James L. , Perroy Ryan , Oestreicher Nicolas 
Published: December 2023

Abstract
Volcanic islands are often subject to flank instability, resulting from a combination of magma intrusions along rift zones, gravitational spreading and extensional faulting observed at the surface. Here we study the Kīlauea volcano in Hawaiʻi, one of the most active volcanoes on Earth, prone to flank instability. Two rift zones and the Koaʻe fault system are major structures controlling volcano flank instability and magma propagation. The connection between surface faulting and magma intrusions at depth is poorly studied despite the importance of faults in controlling magma pathways and forecasting future eruptions. In March 2022, we completed a helicopter photogrammetric survey covering part of the south flank of Kīlauea. We generated a high-resolution DEM (~ 8 cm) and orthomosaic (~ 4 cm) to map the fracture field in detail. We also collected ~ 1000 ground structural measurements of extensional fractures during our three field missions (2019, 2022, 2023) to better understand the kinematics of the Kīlauea’s south flank. In our analysis, we include many small, interconnected grabens, monoclines, rollover structures, and en-echelon fractures that were in part previously undocumented. Additionally, we estimate the cumulative displacement across the Koaʻe fault system during the last 600 years and found an average of 6 cm and 3 cm per year for vertical and horizontal directions, respectively, consistent with short-term GNSS data. These data provide a clearer picture of the structural linkages between the fault zone, which is largely a tectonic feature, and the rift zones, which are largely magmagenic. Finally, we propose a kinematic model of Kīlauea’s south flank suggesting a clockwise rotation and translation of a triangular wedge in response to the gravitational spreading and the nearby rift zones.
Forecasting the ecological footprint of G20 countries in the next 30 years
Authors: Eufrasio-Espinosa Rafael , Koh Lenny 
Published: December 2023

Abstract
The Ecological Footprint evaluates the difference between the availability of renewable resources and how much of these resources humans consume. During the last few decades, historical records show an accelerated decline in resource availability. Based on the national footprint and biocapacity accounts, this analysis aims to further develop the forecasting of the G20 countries' ecological footprint over a 30-year time frame. We used a time series forecasting approach implemented in Python, considering modular regression (Prophet) and Autoregressive Integrated Moving Average (ARIMA & Auto-ARIMA) methods, and evaluated and combined the performance of the three methods. The results showed that within the largest economies of the G20, only four countries will have a positive footprint balance by 2050, with a common denominator of large land areas and a moderate projection of population growth. However, the general trend of the indicator shows that it will continue to decline.
Evaluation of Four Deep Learning-Based Postoperative Survival Prediction Models for Hepatocellular Carcinoma Based on SEER
Authors: Cao Guangwen , Jing Chunxia , Liu Wenbin , Wang Weijun , Yang Zhiyu , Zeng Huixian , Niu Zheyun 
Published: December 2023

Abstract
Accurate prognosis prediction is crucial for treatment decisions in HCC patients, but there is limited research investigating the combination of deep learning with time-to-event analysis. This study assessed four models, including deep learning survival neural network (DeepSurv), neural multi-task logistic regression model (N-MTLR), random survival forest (RSF), and traditional Cox proportional hazards (Cox-PH) models in predicting postoperative survival in hepatocellular carcinoma (HCC) patients. Utilizing data from the US SEER database 2004–2015 to, extract and analyze 5420 patients’ baseline demographic and tumor characteristics. The fellow was randomly divided into a training set and an internal testing set in a ratio of 8:2. Four algorithms were employed to build the predictive models after variable selection and was internally validated using metrics such as Harrell's concordance index (C-index), Brier Score, Receiver Operating Characteristic curve (ROC) curve, and calibration curve. DeepSurv, N-MTLR, RSF exhibited greater robustness compared to traditional Cox-PH models. These models aid in identifying patients who can benefit from HCC surgery and facilitates early intervention and the reliability of individual treatment recommendations.
Single cell spatial transcriptomics reveals distinct patterns of dysregulation in non-neuronal and neuronal cells induced by the Trem2R47H Alzheimer’s risk gene mutation
Authors: Johnston Kevin , Berackey Bereket B , Tran Kristine Minh , Gelber Alon , Yu Zhaoxia , MacGregor Grant , Mukamel Eran A , Tan Zhiqun , Green Kim , Xu Xiangmin 
Published: December 2023

Abstract

INTRODUCTIONThe R47H missense mutation of the TREM2 gene is a strong risk factor for development of Alzheimer’s Disease. We investigate cell-type-specific spatial transcriptomic changes induced by theTrem2R47Hmutation to determine the impacts of this mutation on transcriptional dysregulation.METHODSWe profiled 15 mouse brain sections consisting of wild-type,Trem2R47H, 5xFAD andTrem2R47H; 5xFAD genotypes using MERFISH spatial transcriptomics. Single-cell spatial transcriptomics and neuropathology data were analyzed using our custom pipeline to identify plaque andTrem2R47Hinduced transcriptomic dysregulation.RESULTSTheTrem2R47Hmutation induced consistent upregulation ofBdnfandNtrk2across many cortical excitatory neuron types, independent of amyloid pathology. Spatial investigation of genotype enriched subclusters identified spatially localized neuronal subpopulations reduced in 5xFAD andTrem2R47H; 5xFAD mice.CONCLUSIONSpatial transcriptomics analysis identifies glial and neuronal transcriptomic alterations induced independently by 5xFAD andTrem2R47Hmutations, impacting inflammatory responses in microglia and astrocytes, and activity and BDNF signaling in neurons.