bluuebunny/crossref_metadata_2025_split huggingface dataset:
Caregivers’ socio-cultural influences on health-seeking behavior for their wasted children among forcibly displaced Myanmar Nationals and their nearest host communities
Authors: Naila Nurun Nahar , Islam Md. Munirul , Alam Aklima , Karmakar Gobinda , Mahfuz Mustafa , Mostafa Ishita , Sharmin Farhana , Manir Mohammad Zahidul , Sari Mayang , Ahmed Tahmeed , Rahman Mahfuzur 
Published: November 2023

IntroductionA total of 19% of forcibly displaced Myanmar Nationals (FDMNs) Bangladesh fall within the age range of under five years old, while an average of 1% exhibit severe malnutrition. Cox’s Bazar is the closest host community for FDMNs, with similar traditional culture and religion and shared linguistic, ethnic, and cultural ties.MethodsA qualitative study was conducted to investigate the impact of socio-cultural factors on the healthcare-seeking behavior of caregivers of critically malnourished children in FDMN camps and neighboring host communities.ResultsThe utilization of informal healthcare by caregivers in both populations can be attributed to cultural attitudes, taboos, and peer pressure. The healthcare by practices in the FDMN camps and host towns were primarily affected by household responsibilities, familial assistance in accessing medical services, decisions made by husbands or mothers-in-law, and the availability and accessibility of healthcare facilities. Certain features were identified that prompt caregivers to seek formal treatment in both groups. The efficacy of the treatment was a primary consideration. In instances where conventional remedies and informal treatments proved ineffective in restoring the health of children, others who were invested in their well-being, such as family members and neighbors, advised caretakers to pursue professional medical care.DiscussionEnhanced caregiver awareness of severe wasting, enhanced healthcare accessibility, and increased community volunteer engagement have the potential to facilitate early identification of severely wasted children and mitigate delays in treatment.
Outcome and treatment-related adverse events of combined immune checkpoint inhibition with flipped dosing in a real-world cohort of 79 patients with metastasized melanoma
Authors: Nübel Charlotte , Amaral Teresa , Leiter Ulrike , Flatz Lukas , Forschner Andrea 
Published: November 2023

IntroductionCombined immune checkpoint inhibition (ICI) with ipilimumab and nivolumab is a widely used treatment regimen for metastatic melanoma with non-resectable metastases. Nevertheless, the standard dose of ipilimumab 3 mg/kg bw and nivolumab 1 mg/kg bw is associated with a high rate of treatment-related adverse events (trAEs) (59% grade 3–4). In the CheckMate 511 study, it could be shown that flipped dosing with ipilimumab 1 mg/kg bw and nivolumab 3 mg/kg bw resulted in a significant reduction of trAE.MethodsWe have also used this regimen in the clinical setting and report the trAE, progression-free survival, and overall survival for 79 patients with metastatic melanoma who started combined ICI in the flipped dosing between March 2019 and April 2020.Resultsin total, 40 patients started first-line, 50% of whom had an elevated lactate dehydrogenase level at baseline. The disease control rate of these patients was 50%. The 2-year overall survival rate 67%. Moreover, 33% of the patients suffered grade 3 or 4 treatment related adverse events. DiscussionThe results of our study correspond very well to the results of the CheckMate 511 study (2-year OS: 65%, grade 3-4 immune-related side effects: 35%). Combined ICI with ipilimumab 1 mg/kg bw and nivolumab 3 mg/kg bw seems to be an equally effective but better-tolerated therapy regimen for metastasized melanoma patients, also in a real-world cohort.
Incidence trends in prostate cancer among men in the United States from 2000 to 2020 by race and ethnicity, age and tumor stage
Authors: Du Xianglin L. , Gao Daoqi , Li Zhuoyun 
Published: November 2023

PurposeTo explore whether prostate cancer incidence trends from 2000 to 2020 in the United States differed by race and ethnicity, age and tumor stage; to explore racial differences in prostate cancer incidence change due to the impact of COVID-19 pandemic lockdown in 2020; and to determine if there is any high-risk population that can be targeted for prevention.MethodsWe identified 1,098,349 men who were diagnosed with incident prostate cancer at age ≥20 in 2000-2020 in 17 registries of the Surveillance, Epidemiology, and End Results (SEER) program in the United States; of whom, 778,437 were non-Hispanic whites, 155,111 non-Hispanic blacks, 4,200 American Indians and Alaska Natives (AIAN), 55,267 non-Hispanic Asians/Pacific Islanders, and 105,334 Hispanics.ResultsAge-adjusted incidence rate of prostate cancer was the highest in blacks (302.6 cases per 100,000 men), followed by whites (186.6), Hispanics (153.2), AIAN (108.5), and Asians (104.9). Age-adjusted prostate cancer incidence rates dramatically decreased from 2000 to 2013 for all ethnic men. However, age-adjusted prostate cancer incidence rates increased from 2014 to 2020, in which the increasing incidence trend looked sharper in blacks and whites, flatter in Asians, and leveled in AIAN and Hispanics. Among men with local or regional stages across all years, prostate cancer incidence rate was significantly higher in blacks, but significantly lower in Hispanics, AIAN, and Asians as compared to whites. Among men in 2007-2013, the risk of distant stage prostate cancer was statistically significantly elevated in blacks (rate-ratio: 2.22, 95% CI: 2.06-2.38) and Hispanics (1.16, 1.06-1.25), not significantly different in AIAN (1.30, 0.92-1.76), but still significantly lower in Asians (0.73, 0.66-0.82) as compared to whites. There was a drop of prostate cancer incidence from 2019 to 2020 likely due to the impact of COVID-19 pandemic lockdown on the access to medical care in 2020. Overall prostate cancer incidence rate decreased by 40.4 cases per 100,000 population from 277.4 in 2019 to 237.0 in 2020 for blacks, 20.9 from 164.2 to 143.3 for whites, 16.8 from 124.8 to 108.0 for Hispanics, 14.9 from 101.7 to 86.8 for AIAN, and 12.6 from 88.4 to 75.8 for Asians.ConclusionThe decreasing trend of prostate cancer incidence from 2000 to 2013 was statistically significant for all ethnic men. There was an increasing prostate cancer incidence from 2014 to 2020. Age-adjusted incidence rate of prostate cancer was the highest in blacks, followed by whites, Hispanics, AIAN, and Asians, regardless of age groups, tumor stages, and time periods. There will also be a need to monitor and investigate the prostate cancer incidence trend during and after COVID-19 pandemic season.
Personality, negative affectivity and emotional intelligence: gender-differentiated relationships with physical exercise
Authors: Campos-Uscanga Yolanda , Argüelles-Nava Vianey , Mejia-Castillo Aurora , Barradas-Landa Rosa Maribel , Rosas-Campos Kassandra , Narave-Moreno Mirei 
Published: November 2023

IntroductionPhysical exercise is one of the most relevant lifestyle choices for the prevention of diseases; however, participation in this type of activity remains low. Therefore, it is necessary to deepen the understanding of related psychological factors in men and women.ObjectiveTo determine whether personality traits, emotional intelligence and negative affective are differentially related to physical exercise characteristics in men and women.MethodA cross-sectional study was conducted with 579 physically active people (61.1% men) between 18 and 59 years of age. The Big Five Inventory (BFI-15p), Brief Emotional Intelligence Scale (EQ-i-M20), and Depression, Anxiety and Stress Scale (DASS-21) were used.ResultsCompared with men, women exercised fewer days and minutes per week, had fewer years of participation and performed fewer different physical exercises. On the emotional intelligence scale, compared with men, women showed less stress management, adaptability and general mood but greater interpersonal intelligence. With regard to personality traits, compared with men, women showed greater openness, conscientiousness, agreeableness, and neuroticism. In males, heightened levels of general mood and extraversion were associated to a lasting commitment to physical exercise over time. Conversely, in females, depression was negatively associated with the years dedicated to physical exercise.ConclusionDistinct approaches are essential for men and women, acknowledging the varied ways psychological factors are linked to physical exercise based on gender.
The impact of childhood maltreatment on aggression, criminal risk factors, and treatment trajectories in forensic psychiatric patients
Authors: Koolschijn Marijtje , Janković Marija , Bogaerts Stefan 
Published: November 2023

IntroductionChildren’s development into healthy well-functioning adults can be negatively affected by adversity. Adverse childhood experiences (ACEs) have been shown to lead to a variety of poor life outcomes, ranging from mental health problems (e.g., anxiety or suicidality) through problematic health behaviors to serious physical diseases and even early death. ACEs can also make people more prone to aggressive behavior, criminality, and recidivism. In this study, we investigated the association between ACEs, specifically childhood maltreatment (CM), and forensically relevant factors; aggression, criminal risk factors, and treatment trajectories, as little is known about these associations in forensic psychiatric patients.MethodsThe study includes data derived from two studies in The Netherlands, of which the first study enrolled 128 patients residing in a Forensic Psychiatric Center (FPC) and the second study included 468 patients who were released unconditionally from FPCs between 2009 and 2013. We expected that more CM would be correlated with higher levels of aggression, higher clinical risk factor scores, and less decrease in clinical risk factor scores over time. To investigate this, we applied correlational analyses and linear growth curve modeling on risk assessment scores and self-report as well as staff report questionnaires on CM and aggression.ResultsConsistent with our first hypothesis, patients with higher CM scores also had higher aggression and risk assessment scores. The effect sizes were small to medium (0.12 to 0.34). Unexpectedly, CM did not influence the course of these treatment trajectories, however, we found that patients with histories of CM had a significantly longer length of stay in a forensic facility than patients without CM (respectively, 10.8 years and 9.3 years on average).DiscussionThis study underlines the importance of carefully examining the history of ACEs and CM in forensic psychiatric patients and considering this in forensic risk assessment and risk guided treatment. More research is needed to draw conclusions about whether and how histories of ACEs should be considered and targeted during treatment trajectories.
Exploring Zentangle as a virtual mindfulness-based art intervention for people with serious mental illness
Authors: Stojcevski Marko , Cheung Amy , Agwu Victor , Fan Xiaoduo 
Published: November 2023

IntroductionZentangle is an emerging art intervention that incorporates mindfulness into creative drawing. This pilot study explored Zentangle as a novel adjunct treatment for people with serious mental illness (SMI).MethodsSix participants with SMI completed an 8-week Zentangle program. Psychiatric outcomes were evaluated using the Brief Psychiatric Rating Scale (BPRS), Mindful Attention Awareness Scale (MAAS), Perceived Stress Scale (PSS), and Quality of Life Enjoyment and Satisfaction Scale (Q-LES-Q-SF). A focus group was conducted to better understand the experiences of the participants.ResultsA significant reduction in psychiatric symptoms was observed as measured by the total score on the BPRS between baseline and 5-week post-intervention (40.7 ± 9.1 vs. 33.7 ± 8.9, mean ± SD, p = 0.02). Participants also showed a significant increase in mindful attention using the average score on the MAAS between 1- and 5-week post-intervention (3.5 ± 0.4 vs. 4.2 ± 0.7, mean ± SD, p = 0.04). Four themes were generated from the focus group: (1) approaching mindfulness through Zentangle; (2) power of uncomplicated art creation; (3) understanding the value of self-appreciation; and (4) fostering a positive environment.DiscussionOur preliminary data suggest that the use of Zentangle for participants with SMI may have a positive impact on overall psychiatric symptoms and mindfulness. Moreover, the Zentangle Method encourages positive emotions like gratitude and self-accomplishment to counteract negative feelings of self-criticism and failure in participants.
High perceived stress in patients on opioid agonist therapies during rapid transitional response to the COVID-19 pandemic in Ukraine
Authors: Galvez Samy J. , Altice Frederick L. , Meteliuk Anna , Ivasiy Roman , Machavariani Eteri , Farnum Scott O. , Fomenko Tetiana , Islam Zahedul , Madden Lynn M. 
Published: November 2023

BackgroundThe COVID-19 pandemic resulted in marked disruptions in healthcare delivery in Ukraine related to emergency guidance in response to treating opioid use disorder (OUD). Patients with OUD, a group with high levels of comorbid medical and psychiatric disorders, and prescribed opioid agonist therapies (OAT) were rapidly shifted to take-home dosing if they were deemed clinically stable. The impact of these shifts on patient stress and related substance use during the pandemic, however, is unknown.MethodsIn early May 2020, 269 randomly selected OAT patients in Ukraine were surveyed to assess their stress level and substance use using the validated Perceived Stress Scale and examined correlates of severe perceived stress.ResultsOverall, 195 (72.5%) met criteria for moderate to severe levels of stress, which was independently correlated with having started OAT within the past 12 months (aOR: 1.33; 95%CI: 1.15–1.55), living in a large metropolitan area (aOR: 1.31; 95%CI: 1.18–1.46), having been asked by others to share their medication (aOR: 1.13; 95%CI: 1.02–1.25), and having an increase of over 10 min in transportation time to get to treatment (aOR: 1.16; 95%CI: 1.04–1.29). Twenty seven (10%) patients felt at high risk of relapse, while 24 (8.9%) patients reported purchasing drugs.ConclusionDuring a time of great uncertainty soon after emergency guidance to the COVID-19 pandemic, there was extraordinary high levels of perceived stress reported. In response to emergency guidance, OAT patients should be screened for perceived stress and certain subgroups should be targeted for additional psychosocial support.
Comparison of Yersinia enterocolitica DNA Methylation at Ambient and Host Temperatures
Authors: Van Hofwegen Dustin J. , Hovde Carolyn J. , Minnich Scott A. 
Published: November 2023

Pathogenic bacteria recognize environmental cues to vary gene expression for host adaptation. Moving from ambient to host temperature, Yersinia enterocolitica responds by immediately repressing flagella synthesis and inducing the virulence plasmid (pYV)-encoded type III secretion system. In contrast, shifting from host to ambient temperature requires 2.5 generations to restore motility, suggesting a link to the cell cycle. We hypothesized that differential DNA methylation contributes to temperature-regulated gene expression. We tested this hypothesis by comparing single-molecule real-time (SMRT) sequencing of Y. enterocolitica DNA from cells growing exponentially at 22 °C and 37 °C. The inter-pulse duration ratio rather than the traditional QV scoring was the kinetic metric to compare DNA from cells grown at each temperature. All 565 YenI restriction sites were fully methylated at both temperatures. Among the 27,118 DNA adenine methylase (Dam) sites, 42 had differential methylation patterns, while 17 remained unmethylated regardless of the temperature. A subset of the differentially methylated Dam sites localized to promoter regions of predicted regulatory genes including LysR-type and PadR-like transcriptional regulators and a cyclic-di-GMP phosphodiesterase. The unmethylated Dam sites localized with a bias to the replication terminus, suggesting they were protected from Dam methylase. No cytosine methylation was detected at Dcm sites.
La utopía encubierta: estrategias de localización de la aventura de ciencia ficción en El Eternauta (1957-1959) de Héctor G. Oesterheld y Francisco Solano López
Authors: Quereilhac Soledad 
Published: November 2023

El presente artículo indaga en las razones que llevaron a la historieta argentina El Eternauta, creada por Héctor German Oesterheld y Francisco Solano López, a convertirse en una obra de exitosa recepción durante su publicación original por entregas en Hora Cero Semanal, entre 1957 y 1959, y en las sucesivas reediciones posteriores, hasta convertirse hoy en un “clásico” de la ficción argentina. Se analiza el paso de Oesterheld por la revista Más Allá (1953-1957) y sus comienzos como cuentista, guionista de historietas y divulgador de temas científicos en sellos comerciales y, luego, en su propio sello, Frontera. El perfil profesional del autor fue la condición de emergencia de una forma particular de la historieta, donde se combinaron con eficacia convenciones de la industria cultural y un proyecto creativo individual.
Se sostiene la hipótesis de que, en El Eternauta, tras la escena distópica, aflora como subtexto la utopía de una vida argentina con perspectivas de progreso, marcada por la sociabilidad masculina y la armonía de una familia tipo, el manejo de saberes técnico-científicos que recorren el amplio espectro de lo académico, lo fabril y el amateurismo, y los lazos de solidaridad y de filantropía que movilizan las acciones de la resistencia. La distopía permite hacer emerger, así, en posición de riesgo y de amenaza, esa construcción idealizada y afirmativa de la vida en común, de identificables rasgos nacionales.
Pemanfaatan E-Commerce Pada Penjualan Produk Usaha Asinan Myesha Di Kota Kendari
Authors: Siama Romi Apriadi , Nuryadi Ahmad Muhlis , Rosmalah Sitti 
Published: November 2023

This study aims to determine the use of e-commerce in product sales Myesha pickled business in kendari city. This research was conducted from June to July 2023. The data used in this study is primary data obtained by conducting interview directly with the owner of the Myesha Asinan business. Method of collecting data In this study using a survey method. The analytical method used in this research is a descriptive method with a quantitative approach, to describe sales Asinan Myesha business products in utilizing e-commerce. The results of the research show that the benefits of e-commerce in selling Asinan Myesha business products, that is, can help expand market reach, increase brand awareness, make it easy for customers to make purchases, save costs, manage shipments more easily, and can help increase the number of orders and sales turnover.
Keywords: utilization, e-commerce, sales, business, pickles
THE MAJOR OF PRESCHOOL EDUCATION ART CLASSROOM MANAGEMENT BIBLIOMETRIC RESEARCH
Authors: Qiu Si 
Published: November 2023

This study takes the research on the management of art classroom teaching in preschool education majors as the starting point, combines the actual work requirements of kindergartens for the artistic ability of preschool education majors, and investigates and analyzes the current situation of art classroom teaching management in preschool education majors. Teaching management reforms and suggestions such as content and objectives. To ensure that graduates of preschool education majors can manage kindergarten art activities, improve teaching management methods that strengthen practical abilities in art courses of preschool education majors, and make some useful explorations for cultivating qualified and excellent kindergarten teachers and managers.
Art classes in preschool education majors have dual attributes of theoretical and practical training. This study is based on influencing factors such as students' artistic foundation, classroom conditions, and the artistic quality of teachers. In the research and integration of various variables, new questions will inevitably arise, which will be another starting point for exploring art classroom management.
THE EFFECTIVENESS OF USING A VITAMIN PREPARATION WHEN RAISING MARKET CHICKENS
Authors: Ежова О.Ю. , Бакаева Л.Н. , Беляцкая Ю.Н. 
Published: November 2023

В статье приводятся результаты изучения возможности повышения качественных показателей пищевых яиц путём ввода в комбикорм комбинированного витаминного препарата ВитОкей. При определении качественных показателей яиц установлено, что масса яиц была больше во II опытной группе, по сравнению с контрольной, на 0,5 г, с Iопытной – на 0,2 г, с IIIопытной – на 0,1 г. Толщина скорлупы яиц с возрастом птицы снижается у всех подопытных групп. Наличие в комбикорме витаминов большей концентрации способствовало лучшему минеральному обмену, в частности, кальция и фосфора. Поэтому толщина скорлупы у Iи IIIопытных групп осталась на прежнем уровне, а во II опытной группе – увеличилась. Интенсивность яйценоскости у кур всех групп за исследуемый период была достаточно высокой – 86,8–92,5%. Более высокий показатель интенсивности был характерен для кур-несушек IIопытной группы. Показатели IIIопытной группы свидетельствуют, о нецелесообразности ввода препарата ВитОкей в комбикорм в дозе 0,80 мл на 1 литр воды, так как яйценоскость кур-несушек снижается.
The article presents the results of a study of the possibility of increasing the quality indicators of edible eggs by introducing the combined vitamin preparation VitOkey into the mixed feed. When determining the quality indicators of eggs, it was found that the weight of eggs was higher in the second experimental group, compared to the control group by 0.5 g, in the first experimental group – by 0.2 g, in the third experimental group – by 0.1 g. The thickness of the egg shell decreases with the age of the bird in all experimental groups. The presence of higher concentrations of vitamins in the mixed feed contributed to better mineral metabolism, in particular calcium and phosphorus. Therefore, the thickness of the shell in the I and III experimental groups remained at the same level, and in the II experimental group it increased. The intensity of laying ability in chickens of all groups during the researched period was quite high – 86.8–92.5%. A higher intensity indicator was typical for laying hens of the II experimental group. The parameters of the third experimental group indicate the inexpediency of introducing the preparation VitOkey into the mixed feed at a dose of 0.80 ml per 1 liter of water, since the laying ability of laying hens is reduced.