bluuebunny/crossref_metadata_2025_split huggingface dataset:
Pro‐Regenerative Glycopeptide Hydrogel Activates Type 2 Immune Response for Wound Healing via Macrophage‐T Cell Crosstalk
Authors: Wang Jingrong , Liu Xiang , Wang Yaping , Zhang Yushan , Gao Rui , Gao Yu , Kong Pengxu , Huangfu Yini , Zhang Chuangnian , Feng Zujian , Huang Pingsheng , Yang Pengxiang , Wang Weiwei 
Published: January 2024

AbstractImmunomodulatory biomaterials are increasingly used in regenerative medicine. Biomimetic glycopeptide hydrogel is found to accelerate cutaneous wound healing by inducing macrophage M2‐type polarization, however, it is unclear whether this will possibly orchestrate a pro‐regenerative T cell immunity. Here the aim of this study is to elucidate the reparative T‐cell immune response in tissue regeneration by augmenting macrophage‐T cell crosstalk with a novel immunomodulatory glycopeptide hydrogel (termed as GRKgel) self‐assembled by mannose receptor‐binding glucomannan (GM) chemically grafted with RADA16‐conjugated T‐cell epitope. The glycopeptide can be phagocytized and processed by macrophages, which then presents peptides to naïve T cells and polarizes them into T helper 2 (TH2) cells through IL‐4‐dependent STAT6/GATA3 or c‐Maf pathways. Strikingly, full‐thickness skin wound repair in mice indicates a superior efficacy of GRKgel on restoring the pathological structure and hair follicle by provoking TH2 immune response, increasing the residence of M2 macrophages, as well as promoting angiogenesis at the local tissue environment. Furthermore, genomics results illustrates the role of GRKgel serving as an immunomodulatory niche, orchestrating immune cell crosstalk and promoting extracellular matrix (ECM) reconstruction. Collectively, this study highlights the significance of crosstalk between immune cells in evoking pro‐healing T‐cell immunity, providing a promising drug‐/cytokine‐free strategy for endogenous tissue regeneration.
Unravelling Size‐Dependent and Coupled Properties in Mechanical Metamaterials: A Couple‐Stress Theory Perspective
Authors: Eskandari Shahin , shahryari Benyamin , Akbarzadeh Abdolhamid 
Published: January 2024

AbstractThe lack of material characteristic length scale prevents classical continuum theory (CCT) from recognizing size effect. Additionally, the even‐order material property tensors associated with CCT only characterize the materials' centrosymmetric behavior and overlook their intrinsic chirality and polarity. Moreover, CCT is not reducible to 2D and 1D space without adding couples and higher‐order deformation gradients. Despite several generalized continuum theories proposed over the past century to overcome the limitations of CCT, the broad application of these theories in the field of mechanical metamaterials has encountered significant challenges. These obstacles primarily arise from a limited understanding of the material coefficients associated with these theories, impeding their widespread adoption. Implementing a bottom‐up approach based on augmented asymptotic homogenization, a consistent and self‐sufficient effective couple‐stress theory for materials with microstructures in 3D, 2D, and 1D spaces is presented. Utilizing the developed models, material properties associated with axial‐twist, shear‐bending, bending‐twist, and double curvature bending couplings in mechanical metamaterials are characterized. The accuracy of these homogenized models is investigated by comparing them with the detailed finite element models and experiments performed on 3D‐printed samples. The proposed models provide a benchmark for the rational design, classification, and manufacturing of mechanical metamaterials with programmable coupled deformation modes.
The future of research on sustainable food systems: Building an early‐career network of agricultural economists in Europe
Authors: Dalhaus Tobias , Steinhübel Linda , Dalheimer Bernhard , Colen Liesbeth 
Published: January 2024

AbstractThe agricultural economics profession plays an essential role in the transition towards more sustainable and resilient food systems. The interdisciplinary perspective of the profession, the rapidly evolving methods and new data, as well as the diverse agricultural, climatic, and political and cultural landscapes of the European Union member states and associated countries pose specific challenges. In this study, we summarize what this implies for Early‐Career researchers and how the European Network of Early Career Agricultural Economists (AgEconMeet) tries to support these youngsters in their career development. Finally, we introduce the articles of this special issue that represent the diverse landscape of agricultural economics in Europe. [EconLit Citations: A11, Q1, Q18].
Thermally Healable Electrolyte‐Electrode Interface for Sustainable Quasi‐Solid Zinc‐ion Batteries
Authors: Yang Zefang , Zhang Qi , Wu Tingqing , Li Qinke , Shi Jiameng , Gan Jinqiu , Xiang Shaoe , Wang Hao , Hu Chao , Tang Yougen , Wang Haiyan 
Published: January 2024

AbstractQuasi‐solid zinc‐ion batteries using hydrogel electrolytes show great potential in energy storage devices owing to their intrinsic safety, fewer side reactions and wide electrochemical windows. However, the dendrite issues on the zinc anodes cannot be fundamentally eliminated and the intrinsic anode‐electrolyte interfacial interspace is rarely investigated. Here, we design a dynamically healable gelatin‐based hydrogel electrolyte with a highly reversible sol‐gel transition, which can construct a conformal electrode‐electrolyte interface and further evolve into a stable solid‐solid interface by in situ solidification. The unique helical gelatin chain structure provides a uniform channel for zinc ion transport by the bridging effect of sulfate groups. As a consequence, the dynamically healable interface enables dendrite‐free zinc anodes and repeatedly repairs the anode‐electrolyte interfacial interspaces by the reversible sol‐gel transition of gelatin electrolyte to retain long‐lasting protection for sustainable zinc‐ion batteries.
Accelerating the Reaction Kinetics of CO2 Reduction to Multi‐Carbon Products by Synergistic Effect between Cation and Aprotic Solvent on Copper Electrodes
Authors: Bai Xiaowan , Chen Chaojie , Zhao Xunhua , Zhang Yehui , Zheng Yao , Jiao Yan 
Published: January 2024

AbstractImproving the selectivity of electrochemical CO2 reduction to multi‐carbon products (C2+) is an important and highly challenging topic. In this work, we propose and validate an effective strategy to improve C2+ selectivity on Cu electrodes, by introducing a synergistic effect between cation (Na+) and aprotic solvent (DMSO) to the electrolyte. Based on constant potential ab initio molecular dynamics simulations, we first revealed that Na+ facilitates C−C coupling while inhibits CH3OH/CH4 products via reducing the water network connectivity near the electrode. Furthermore, the water network connectivity was further decreased by introducing an aprotic solvent DMSO, leading to suppression of both C1 production and hydrogen evolution reaction with minimal effect on *OCCO* hydrogenation. The synergistic effect enhancing C2 selectivity was also experimentally verified through electrochemical measurements. The results showed that the Faradaic efficiency of C2 increases from 9.3 % to 57 % at 50 mA/cm2 under a mixed electrolyte of NaHCO3 and DMSO compared to a pure NaHCO3, which can significantly enhance the selectivity of the C2 product. Therefore, our discovery provides an effective electrolyte‐based strategy for tuning CO2RR selectivity through modulating the microenvironment at the electrode‐electrolyte interface.
Rapid Synthesis of Chiral Figure‐Eight Macrocycles Using a Preorganized Natural Product‐Based Scaffold
Authors: Honda Tasuku , Ogata Daiji , Tsurui Makoto , Yoshida Satoshi , Sato Sota , Muraoka Takahiro , Kitagawa Yuichi , Hasegawa Yasuchika , Yuasa Junpei , Oguri Hiroki 
Published: January 2024

AbstractChiral D2‐symmetric figure‐eight shaped macrocycles are promising scaffolds for amplifying the chiroptical properties of π‐conjugated systems. By harnessing the inherent and adaptable conformational dynamics of a chiral C2‐symmetric bispyrrolidinoindoline (BPI) manifold, we developed an enantio‐divergent modular synthetic platform to rapidly generate a diverse range of chiral macrocycles, spanning from 14‐ to 66‐membered rings, eliminating the need for optical resolution. Notably, a 32‐membered figure‐eight macrocycle showed excellent circularly polarized luminescence (CPL: |glum|=1.1×10−2) complemented by a robust emission quantum yield (Φfl=0.74), to achieve outstanding CPL brightness (BCPL: ϵ×Φfl×|glum|/2=480). Using quadruple Sonogashira couplings, this versatile synthetic platform enables precise adjustments of the angle, distance, and length among intersecting π‐conjugated chromophores. Our synthetic strategy offers a streamlined and systematic approach to significantly enhance BCPL values for a variety of chiral D2‐symmetric figure‐eight macrocycles.
Kinetics and thermal properties of polydiethylsiloxane initiated by potassium trimethylsilanolate
Authors: Ji Yanwei , Zhao Yan , Xu Rui , Dai Lina , Zhang Zhijie , Fei Hua‐Feng 
Published: January 2024

AbstractThis work reports the kinetics of anionic ring‐opening polymerization of hexaethylcyclotrisiloxane (D3Et) with potassium trimethylsilanolate as initiator and diglyme and N,N‐dimethylformamide (DMF) as promoters. The polymerization rate of D3Et is influenced by the nature of promoters and the reaction temperatures. With the use of DMF as a promoter, the polymerization activation energy is 107.89 kJ/mol, and the polymerization rate constant at 110°C is 0.08466 min−1 with [P]/[I] = 3.0. Gel permeation chromatography and 29Si NMR spectra showed that the intermolecular redistribution occurred during the late stage of polymerization, which facilitated the synthesis of high‐molecular‐weight polydiethylsiloxane (PDES). Differential scanning calorimetry analysis showed that PDES exhibited a glass transition temperature of −142°C and complex crystallization phenomena. Thermogravimetric analysis illustrated that the PDES that was prepared using this method had good thermal stability with onset decomposition temperatures of 483 and 452°C under nitrogen and air conditions, respectively. This work presents innovative approaches for achieving a more energy‐efficient synthesis of PDES to meet the demands of industrial‐scale production.
Dependence of the Al Distribution in CHA Zeolite on the Presence of Na+ during the Synthesis. An EPR Investigation of Cu Species in CuCHA
Authors: Gao Qi , Nielsen David , Mossin Susanne 
Published: January 2024

AbstractCopper‐exchanged zeolites, such as CuCHA are active catalysts for removing NO and NO2 from automotive exhaust. The zeolite synthesis is decisive for the aluminium distribution in the framework and the properties of the catalyst. We have applied in‐situ EPR spectroscopy on CuCHA based on CHA synthesized in four different ways. We found that different mineralizing agents led to differences in the Cu distribution in the final product. Several distinct Cu sites were present after thermal activation according to the EPR spectra and we found that the presence of Na+ during the synthesis boosted the forming of “paired” Al close to Cu, but at the same time limited the ion‐exchange capacity and the redox activity. Two types of well‐defined EPR spectra were found, Site A and Site B. Site B was redox active and catalytically active for all investigated materials whereas the properties of Site A depended on the CHA material and consisted of two subtypes distinguished by their reactivity towards NO and NH3. Studies with isotope labeled NH3 showed that the system was highly dynamic. In‐situ EPR was proved to be an excellent spectroscopic technique to investigate the Cu distribution directly and investigate the Al distribution indirectly for CuCHA zeolites.
A Two‐dimensional Metal‐Organic Framework as Promising Cathode for Advanced Lithium Storage
Authors: Zhou Anna , Zheng Junyang , Lei Chengxi , Liang Jiaying , Deng Xiaotong , Wu Zetao , Chuangchanh Phaivanh , Chen Qing , Zeng Ronghua 
Published: January 2024

AbstractAnthraquinone electrode materials are promising candidates for lithium‐ion batteries (LIBs) due to the abundance of anthraquinone and the high theoretical capacity, and good reversibility of the anthraquinone electrodes. However, the active anthraquinone materials are soluble in organic electrolytes, resulting in a sharp decay of capacity during the charge and discharge processes. Herein, we report on a two‐dimensional calcium anthraquinone 2,3‐dicarboxy metal‐organic framework (2D CaAQDC MOF) fabricated using a simple hydrothermal method. The 2D CaAQDC MOF not only effectively inhibits the dissolution of active electrode substances into the electrolyte, but also promotes the diffusion of lithium ion into the pores of the MOF. When used as a cathode for the LIBs, the resulting CaAQDC electrode delivers a high specific capacity of ~100 mAh g−1 at a current density of 50 mA g−1 after 200 cycles, demonstrating its good cycle stability. Even at a high current density of 200 mA g−1, the CaAQDC electrode exhibits a specific capacity of ~60 mAh g−1. The fabricated 2D coordination polymers effectively restrains the dissolution of anthraquinone into the organic electrolyte and enhances the structural stability, which greatly improves the electrochemical performance of anthraquinone. These research results offer a rational molecular design strategy to address the dissolution of this and other active organic electrode materials.
Pharmacokinetics‐Bridging Between Autoinjectors and Prefilled Syringes for Subcutaneous Injection: Case Examples Revealing a Knowledge Gap
Authors: Li Zhe , Du Xiulian , Huang Shiew Mei , Wang Yow‐Ming C. 
Published: January 2024

Comparative pharmacokinetics (PK) studies have efficiently served as the bridge between autoinjectors and prefilled syringes given the underlying principles that comparable exposure could translate to comparable efficacy and safety. This article discusses approaches used to address uncertainties associated with the observation of noncomparable PK leading to the successful introduction of new autoinjector devices for monoclonal antibody and Fc‐fusion protein products. Information from seven case examples suggests a knowledge gap that warrants attention in autoinjector development.
About the quantum‐kinetic derivation of boundary conditions for quasiparticle Boltzmann equations at interfaces
Authors: Bronold F. X. , Willert F. 
Published: January 2024

AbstractQuite a many electron transport problems in condensed matter physics are analyzed with a quasiparticle Boltzmann equation. For sufficiently slowly varying weak external potentials it can be derived from the basic equations of quantum kinetics, provided quasiparticles can be defined and lead to a pole in the quantum‐mechanical propagators. The derivation breaks down, however, in the vicinity of an interface which constitutes an abrupt strong perturbation of the system. In this contribution we discuss in a tutorial manner a particular technique to systematically derive, for a planar, nonideal interface, matching conditions for the quasi‐particle Boltzmann equation. The technique is based on pseudizing the transport problem by two auxiliary interface‐free systems and matching Green functions at the interface. Provided quasiparticles exist in the auxiliary systems, the framework can be put onto the semiclassical level and the desired boundary conditions result. For ideal interfaces, the conditions can be guessed from flux conservation, but for complex interfaces this is no longer the case. The technique presented in this work is geared toward such interfaces.
Dendritic bifunctional nanotraps inside SBA‐15 for highly efficient removal of selected nonsteroidal anti‐inflammatory drugs from wastewater
Authors: Zhu Lixuan , Gou Xiaoyi , Zheng Yajun , Zhang Zhiming , Huang Yajie , Zhang Yan , Li Yun , Zhang Zhiping 
Published: January 2024

AbstractLarge‐pore mesoporous SBA‐15 materials were functionalized with dendritic bifunctional ligands to achieve efficient adsorption of nonsteroidal anti‐inflammatory drugs (NSAIDs) in aqueous solution mainly through a combination of anion‐exchange ability of quaternary ammonium cations and π‐π interaction capability of oxygen activated phenyls. The synthesis of such a dendritic ligand starts from propylamine on SBA‐15 followed by consecutive amine‐epoxy reactions with resorcinol diglycidyl ether (RDGE) and methylamine, and then amination of terminal epoxy with trimethylamine. The results from Fourier‐transform infrared spectroscopy, nitrogen adsorption–desorption measurements and elemental analysis reveal that the bifunctional dendritic nanotraps have been created successfully inside the mesochannels of SBA‐15 (DNT@SBA‐15). Adsorption kinetics for NSAIDs was very rapid following a pseudo‐second‐order kinetic model, and adsorption isotherms were fitted well by the Langmuir isotherm model. Notably, DNT@SBA‐15 demonstrated remarkably high adsorption capacities for NSAIDs, with maximum values of 1037.3 mg g−1 for ibuprofen, 821.3 mg g−1 for naproxen and 781.3 mg g−1 for diclofenac at pH 7.0. The adsorption was presumed to be governed by a dual‐interaction mechanism including electrostatic and van der Waal's interactions. This study demonstrates that the developed dendritic anion‐exchanger can be a promising material for removing NSAIDs adsorption from environmental water.
Novel design and adaptive coordinated energy management of hybrid fuel‐cells/tidal/wind/PV array energy systems with battery storage for microgrids
Authors: Belkhier Youcef , Oubelaid Adel 
Published: January 2024

AbstractThis paper proposes a comprehensive solution to the challenges of managing a hybrid microgrid that generates electricity from multiple sustainable energy sources by proposing a coordinated energy management strategy and storage system. As renewable energy generation becomes increasingly popular, it introduces greater intermittency and stochasticity in energy management. To address this issue, a coordinated energy management strategy and storage system is proposed, which includes a fuzzy logic modified super twisting algorithm (MSTA). The objectives are to optimize the design and operation of microgrid including electrical based energy conversion systems such as photovoltaic and wind turbines, fuel cells, tidal energy, electric vehicle charging stations, and main grid. The second objective is to develop an energy management system for hybrid energy storage systems (HESS) and renewable energy sources (RESs) to maximize power production and ensure service continuity and smooth output energy of the microgrid, while also providing optimal benefits. To maintain cost‐effectiveness, an On/Off maximum power point tracking (MPPT) algorithm is also proposed. The contribution of this paper is to provide a solution to the intermittent and stochastic nature of renewable energy management and to improve the efficiency and durability of the energy conversion systems. The proposed management unit provides consistent output power and long‐term service.
Heat and mass transfer under MHD mixed convection in a four‐sided lid‐driven square cavity
Authors: Patel Arvind , Kumar Manoj , Bagai Shobha 
Published: January 2024

AbstractThis paper investigates the heat and mass transfer under magnetohydrodynamic mixed convection flow of a binary gas mixture in a four‐sided lid‐driven square cavity. The enclosure's left wall is sinusoidally heated and acts as a source term, while the right wall functions as a sink. The cavity's horizontal walls are adiabatic and impermeable to mass transfer. The governing equations under Boussinesq approximation and stream function‐vorticity formulation are solved using the alternating‐direction‐implicit scheme, a finite‐difference method. The numerical scheme's consistency and stability are demonstrated using the matrix method. The MATLAB code is written, validated against some existing studies, and used to perform numerical simulations. The numerical solutions are graphically examined by visualizing the streamline, isotherm, and concentration contours for nondimensional parameters, such as Hartmann number , heat absorption or generation coefficient , Richardson number , and buoyancy ratio . The magnetic field modifies the temperature and concentration distribution in the cavity, depending on the convection mode. The magnetic field forces the fluid to stagnate in different regions of the cavity, depending on the mode of convection. It was found that the difference between the maximum and minimum temperature and concentration at the cavity's midpoint increases up to 13 and 10 times, respectively, in the natural convection compared with the forced convection. The average Nusselt number on the vertical walls of the cavity is maximum in natural convection in the absence of a magnetic field but reaches a minimum value at in forced and mixed convection. The average Sherwood number on the cavity's vertical walls decreases with the magnetic field in mixed and natural convection.
Superconducting Quasicrystals
Authors: Takemori Nayuta 
Published: January 2024

AbstractDan Shechtman's discovery of quasicrystals in 1982 introduced the scientific world to aperiodic crystals with unique rotational symmetries, redefining traditional crystallography. Although superconductivity in related periodic approximants has since been observed, true bulk superconductivity in quasicrystals was confirmed only in 2018. This recent discovery opens a new horizon not only for the study of correlated quasicrystals but more generally for the study of superconductivity with nontrivial spatial order. The theoretical understanding of superconducting quasicrystals poses challenges due to their lack of periodicity. Notably, they exhibit non‐BCS type superconductivity and distinct electromagnetic responses, reminiscent of the so‐called FFLO state. In this review, we provide an overview of superconducting quasicrystals, along with some “behind‐the‐scenes” information.
Reserve Bilirubin Binding Capacity Determined by Difference Spectroscopy. I. Modifications and Performance of the Difference Spectroscopy Assay
Authors: Burckart Gilbert J. , Whitington Peter F. , Gross Sharon R. 
Published: January 2024

SummaryThe difference spectroscopy assay for reserve bilirubin binding capacity, modified to improve its performance, was used to study solutions of human serum albumin and bilirubin. The results indicate that the assay is performed simply and rapidly: that it uses very small sample volumes, making it suitable for use in premature human neonates; that it measures reserve binding capacity and not free bilirubin resulting from exceeding binding capacity; that it measures binding at two sites, which can be discriminated by blocking the low‐affinity site with concentrated salicylate: and that it can be performed at varying pH depending upon the experimental need.
Pyloric Channel Duplication in a Newborn Infant
Authors: Birenbaum Emanuel , Avigad Itamar , Bat Leon , Rozenman Judith , Brish Michael 
Published: January 2024

SummaryThis is the first reported case of pyloric channel duplication demonstrated preoperatively by endoscopy and contrast radiography. Endoscopically, the lesion resembled a mucosal flap overlying the pyloric orifice. On radiography the lesion presented as a polypoidal filling defect in the duodenal bulb. The infant had, in addition, postduplication stress ulcer.