bluuebunny/crossref_metadata_2025_split huggingface dataset:
Mosunetuzumab with polatuzumab vedotin in relapsed or refractory aggressive large B cell lymphoma: a phase 1b/2 trial
Authors: Budde Lihua E. , Olszewski Adam J. , Assouline Sarit , Lossos Izidore S. , Diefenbach Catherine , Kamdar Manali , Ghosh Nilanjan , Modi Dipenkumar , Sabry Waleed , Naik Seema , Mehta Amitkumar , Nakhoda Shazia K. , Smith Stephen D. , Dorritie Kathleen , Jia Ting , Pham Song , Huw Ling-Yuh , Jing Jing , Wu Hao , Ead Wahib S. , To Iris , Batlevi Connie Lee , Wei Michael C. , Chavez Julio C. 
Published: December 2023

AbstractRelapsed/refractory aggressive large B cell lymphoma (LBCL) remains an area of unmet need. Here we report the primary analysis of a phase 1b/2 trial of outpatient mosunetuzumab (a CD20xCD3 T-cell-engaging bispecific antibody) plus polatuzumab vedotin (an anti-CD79B antibody–drug conjugate) in relapsed/refractory LBCL. The phase 2 component is a single arm of an ongoing multi-arm trial. The primary endpoint during dose expansion was independent review committee (IRC)-assessed best overall response rate. Secondary endpoints included investigator-assessed overall response rate, complete response, duration of response, progression-free survival and overall survival. At data cutoff, 120 patients were enrolled (22 dose escalation, 98 dose expansion). The primary endpoint was met during dose expansion, with IRC-assessed best overall response rate and complete response rates of 59.2% (58/98; 95% confidence interval (CI): 48.8–69.0) and 45.9% (45/98; 95% CI: 35.8–56.3), respectively (median follow-up, 23.9 months). Median duration of complete was not reached (95% CI: 20.5–not estimable (NE)). Median progression-free survival was 11.4 months (95% CI: 6.2–18.7). Median overall survival was 23.3 months (95% CI: 14.8–NE). Across dose escalation and expansion, the most common grade 3 or higher adverse events were neutropenia (25.0%, 30/120) and fatigue (6.7%, 8/120). Any-grade cytokine release syndrome occurred in 16.7% of patients. These data demonstrate that mosunetuzumab plus polatuzumab vedotin has a favorable safety profile with highly durable responses suitable as second-line therapy in transplant-ineligible relapsed/refractory LBCL. ClinicalTrials.gov identifier: NCT03671018.
Multi criteria analysis of municipal solid waste management and resource recovery in Poland compared to other EU countries
Authors: Vambol Viola , Kowalczyk-Juśko Alina , Vambol Sergij , Khan Nadeem A. , Mazur Andrzej , Goroneskul Marianna , Kruzhilko Oleg 
Published: December 2023

AbstractStatistics show that the inhabitants of Poland are producing increasingly more household waste. This article attempts to determine the current level of development of Poland in the field of waste management concerning other EU countries and partner countries; identify trends in the mass of generated, segregated, and mixed municipal waste; and obtain an idea of the attitude of the Polish population toward sorting waste at the source to bring the country to a higher level of waste management. The empirical base is statistical data published on the website of the EU Data Explorer and the Central Statistical Office. The ranking of countries was determined by the TOPSIS method using a synthetic indicator based on the selected diagnostic features. The significance of the obtained ranks was tested using the non-parametric Friedman test (p < 0.01). We established that Poland has been consistently ranked 16th-17th over the past 5 years. Unfortunately, thus far, no systematic approach has been found to raise citizens' awareness, which may be due to the lack of the necessary amount of data. Researchers recommend investigating the sensitivity of the relationship between the generation of alternative energy from waste and the authorities' action.
Physical education teachers’ knowledge of physical activity recommendations for health promotion in children and adolescents
Authors: Marques Adilson , Iglésias Beatriz , Ramos Gil , Gouveia Élvio R. , Ferrari Gérson , Martins João , Lagestad Pål 
Published: December 2023

AbstractThis study aimed to analyse the knowledge of Portuguese physical education (PE) teachers according to the health recommendations for physical activity (PA) for children and adolescents. A total of 764 teachers participated (55.2% men) with a mean age of 48.2 years. Data was collected using answering to an online survey. Teachers were asked about PA’s frequency, duration and intensity to achieve the recommended level PA. Chi-square was applied to analyse the associations. The main finding is that PE teachers have a lack of knowledge of the health recommendations of PA. Specifically, only 7.5% of the PE teachers in our study could identify the PA recommendations correctly. The intensity component in the health recommendation is the one in which most PE teachers demonstrate correct knowledge of (60.5%), with significant differences in gender and teaching level. However, significantly fewer PE teachers knew the frequency component in the health recommendations for PA (25%), with significant differences in education level. For the duration component, only 37.6% of teachers knew the recommendations. In light of our findings, it is a concern that PE teachers generally lack knowledge according to children’s fulfilment of health recommendations for PA.
Research on multi-dimensional reconstruction mechanism of cloud native full link in the metaverse scenario
Authors: Sheng Shuo 
Published: December 2023

AbstractRecently, the Microservices whole link whole life cycle optimization framework has been a research hotspot in the academic and engineering fields, especially how to encapsulate the component security mechanism and conduct high concurrency testing based on the existing active framework. The whole link delay, load, and cost have always been the key optimization goals of Microservices splitting and deployment logic. Based on this, this paper proposes a multi-objective optimization Microservices framework that takes into account the security mechanism, Define the fitness function, define the upper and lower limits, and perform multi-dimensional constraints to filter for global and local optima. At the same time, reconstruct the circuit breaker current limiting mechanism, dynamically detect protocol parameters, and perceive the logical relationship of heartbeat status in real-time. Experimental results have shown that this innovative framework can solve scenarios such as high concurrency, high reliability, and high availability Performance bottleneck, business degradation, especially in financial and securities scenarios.
Group decision making in the analytic hierarchy process by hesitant fuzzy numbers
Authors: Ranjbar Mahdi , Effati Sohrab 
Published: December 2023

AbstractDue to the increasing complexity of decision problems, many managers employ multiple experts to reach a good decision in a group decision making. Now, if there is ambiguity in the evaluation of experts, the use of fuzzy numbers can be useful for each expert. In these situations, the use of hesitant fuzzy numbers (HFNs) which consists of several fuzzy numbers with special conditions can be suggested. HFNs are as an extension of the fuzzy numbers to take a better determining the membership functions of the parameters by several experts. Because of simple and fast calculations, in this paper, we use triangular HFNs in the pairwise comparison matrix of analytic hierarchy process by opinions of a group of decision makers in a hesitant fuzzy environment. We define consistency of the hesitant fuzzy pairwise comparison matrix and use the arithmetic operations on the HFNs and a new method of comparing HFNs to get the hesitant fuzzy performance score. By using score function to hesitant fuzzy score we can get a final score for alternatives. Finally, a practical example is provided to show the the effectiveness of this study. The obtained results from this paper show that new method can get a better answer by keeping the experts’ opinions in the process of solving the problem.
Association of serum phosphate and changes in serum phosphate with 28-day mortality in septic shock from MIMIC-IV database
Authors: Nan Wenbin , Huang Qiong , Wan Jinfa , Peng Zhenyu 
Published: December 2023

AbstractThis study aimed to investigate the relationship between serum phosphate levels, changes in serum phosphate levels, and 28-day mortality in patients with septic shock. In this retrospective study, data were collected from the Medical Information Mart for Intensive Care IV (MIMIC-IV) database between 2008 and 2019. Patients were divided into three groups according to the tertiles of serum phosphate levels. Kaplan–Meier curves and log-rank test analyses were used for survival analysis. Multivariate logistic regression, and restricted cubic spline (RCS) curve were used to explore the association between serum phosphate, delta serum phosphate levels and 28-day mortality. In total, 3296 patients with septic shock were included in the study, and the 28-day mortality was 30.0%. Serum phosphate levels were significantly higher in the non-survivor group than in the survivor group. The Kaplan–Meier curves showed significant differences among the three groups. Multivariate logistic regression analysis and the RCS curve showed that serum phosphate levels were independently and positively associated with the 28-day mortality of septic shock. Non-survivors had higher delta serum phosphate levels than survivors. Survival analysis showed that patients with higher delta serum phosphate levels had higher 28-day mortality. A non-linear relationship was detected between delta serum phosphate and 28-day mortality with a point of inflection at − 0.3 mg/dL. Serum phosphate levels were positively and independently associated with 28-day mortality in septic shock. Delta serum phosphate level was a high-risk factor for patients with septic shock.
Isolation and evaluation of Qatari soil rhizobacteria for antagonistic potential against phytopathogens and growth promotion in tomato plants
Authors: BiBi Amina , Bibi Shazia , Al-Ghouti Mohammad A. , Abu-Dieyeh Mohammed H. 
Published: December 2023

AbstractPlant growth promoting rhizobacteria are a diverse group of microorganisms that enhance the growth of plants under various conditions. In this study, 55 isolates of endogenous rhizobacteria were collected from the rhizosphere of Avicennia marina, Suaeda vermiculata, Salsola soda, Anabasis setifera, Salicornia europaea, Arthrocnemum macrostachyum, Limonium axillare, Tetraena qatarensis, Aeluropus lagopoides, and Prosopis juliflora. The isolates were evaluated in-vitro for their antagonist potential against Fusarium oxysporum and Botrytis cinerea using the dual culture technique, where the maximum growth inhibition reached 49% and 57%, respectively. In-vivo evaluation was accomplished to determine the growth-promoting potential of the rhizobacteria under greenhouse conditions where the strain ANABR3 (Bacillus subtilis) showed the strongest growth-promoting effects. Further in-vivo testing regarding the effectiveness of rhizobacteria in the presence of the phytopathogen was also completed using the Hoagland medium. LEMR3 and SALIR5 (both identified as two strains of B. subtilis) supported the tomato seedlings to overcome the disease and significantly (p ≤ 0.05) increased above and belowground biomass compared to the control. Additionally, several characterizing tests were carried out on the selected strains, these strains were found to possess numerous features that promote plant growth directly and indirectly such as the production of IAA, HCN, hydrolytic enzymes, ACC deaminase, NH3, and some rhizobacteria were capable of phosphate solubilization. In conclusion, this study showed that local rhizobacterial isolates collected from arid lands possess valuable traits, making them promising bio-control agents and bio-fertilizers for agricultural purposes.
Effects of proprioception and core stability training on gait parameters of deaf adolescents: a randomized controlled trial
Authors: Zarei Hamed , Norasteh Ali Asghar , Lieberman Lauren J. , Ertel Michael W. , Brian Ali 
Published: December 2023

AbstractThe current study aimed to explore the effects of proprioception versus core stability training over 8 weeks on the gait parameters of deaf adolescents. A total of 20 deaf adolescents were randomized into two groups: one group receiving proprioception training (PT, n = 10), another group receiving core stability training (CST, n = 10), and eleven typically developing adolescents assigned into the control group (CON; n = 11). Gait was recorded by two digital cameras; then, using the Kinovea software, the parameters of gait included: gait velocity, cadence, stride length, stride time, stance time, and swing time were calculated in terms of percentages of the walking cycle. After 8 weeks of PT, no significant differences were observed for all gait parameters between PT and control groups (p > 0.05). Also, after 8 weeks of CST, no significant differences were observed in gait velocity and cadence between the CST and control groups (p > 0.05). However, after 8 weeks of CST, stride length (p = 0.02) was higher in the control group; Stride time (p = 0.03), stance time (p = 0.04) and swing time (p = 0.04) were higher in the CST group. Moreover, after 8 weeks of PT, values showed significant improvements in all gait parameters (p = 0.001). Also, after 8 weeks of CST, values showed significant improvements in gait velocity and cadence (p = 0.001), but no significant differences were observed in other gait parameters (p > 0.05). The findings of this study indicated that PT improved all gait parameters, whereas CST improved gait velocity and cadence. The results of the present study also demonstrated that PT had a greater effect on gait parameters of deaf adolescents compared with CST. It seems that PT induces more training effects than CTS for enhancing gait parameters of deaf adolescents.Trial registration: Clinical trial registry number: IRCT20170312033029N2. URL:https://en.irct.ir/trial/25584.
Extracellular volume by dual-energy CT, hepatic reserve capacity scoring, CT volumetry, and transient elastography for estimating liver fibrosis
Authors: Mizuno Mariko , Tago Kenichiro , Okada Masahiro , Nakazawa Yujiro , Arakane Takayuki , Yoshikawa Hiroki , Abe Hayato , Matsumoto Naoki , Higaki Tokio , Okamura Yukiyasu , Takayama Tadatoshi 
Published: December 2023

AbstractOur purpose was to compare the efficacy of liver and splenic volumetry (LV and SV), extracellular volume (ECV) on dual-layer spectral-detector CT scoring systems for estimating liver fibrosis (LF) in 45 patients with pathologically staged LF. ECV measured on CT value (HU-ECV), iodine density (ID-ECV), atomic number (Zeff-ECV), and electron density (ED-ECV), LV or SV/body surface area (BSA), albumin bilirubin grade (ALBI), model for end-stage liver disease (MELD) score, aspartate aminotransferase platelet ratio index (APRI), and fibrosis index based on the four factors (FIB-4) were recorded. Transient elastography was measured in 22 patients, and compared to ECV. No correlation was found between transient elastography and all ECVs. Area under the curve (AUC) for estimating F4 on transient elastography was 0.885 (95% CI 0.745–1.000). ALBI was weakly associated with LF (p = 0.451), while MELD (p < 0.001), APRI (p = 0.010), and FIB-4 (p = 0.010) were significantly associated with LF. SV/BSA had a higher AUC than MELD, APRI, and FIB-4 for estimating F4 (AUC = 0.815, 95% CI 0.63–0.999), but MELD (AUC = 0.799, 95% CI 0.634–0.965), APRI (AUC = 0.722, 95% CI 0.561–0.883), and FIB-4 (AUC = 0.741, 95% CI 0.582–0.899) had higher AUCs than ALBI. SV/BSA significantly contributed to differentiation for estimating F4; odds ratio (OR) was 1.304–1.353 (Reader 1–2; R1–R2), whereas MELD significantly contributed to the differentiation between F0–2 and F3–4; OR was 1.528–1.509 (R1–R2). AUC for SV/BSA and MELD combined was 0.877 (95% CI 0.748–1.000). In conclusion, SV/BSA allows for a higher estimation of liver cirrhosis (F4). MELD is more suitable for assessing severe LF (≥ F3–4). The combination of SV/BSA and MELD had a higher AUC than SV/BSA alone for liver cirrhosis (F4).
Multidrug-resistant organisms may be associated with bed allocation and utilization efficiency in healthcare institutions, based on national monitoring data from China (2014–2020)
Authors: Wang Xing-Tian , Meng Hua , Pan Dong-Feng , Zheng Xiao-Yu , Lu Wen-Wen , Chen Chen , Su Ming , Su Xin-Ya , Liu Zhuo , Ma Xiao-Juan , Liang Pei-Feng 
Published: December 2023

AbstractAnalyzing the influence of the bed allocation and utilization efficiency in healthcare institutions on the isolation proportion of Multidrug-resistant organisms (MDROs) to provide data to support prevention and control of MDROs. In this study, the provincial panel data from 2014 to 2020 in China on health resource indicators, including the number of beds per 1,000 population, hospital bed utilization rate, and average hospital stay from 2014 to 2020 in China were used to analyze the relationship between bed allocation or utilization efficiency and MDROs by the panel data quantile regression model. It was shown that the number of beds per 1,000 population had a negative effect on the isolation proportion of methicillin-resistant Staphylococcus aureus, vancomycin-resistant Enterococcus faecalis, vancomycin-resistant Enterococcus faecium, penicillin-resistant Streptococcus pneumoniae, methicillin-resistant coagulase-negative Staphylococcus, and cefotaxime or ceftriaxone resistant Escherichia coli (regression coefficient < 0, P < 0.05). The utilization rate of hospital bed had a positive effect on the isolation proportion of methicillin-resistant Staphylococcus aureus, methicillin-resistant coagulase-negative Staphylococcus, vancomycin-resistant Enterococcus faecium, penicillin-resistant Streptococcus pneumoniae, cefotaxime or ceftriaxone resistant Escherichia coli, carbapenem-resistant Escherichia coli, cefotaxime or ceftriaxone resistant Klebsiella pneumoniae, carbapenem-resistant Klebsiella pneumoniae, carbapenem-resistant Pseudomonas aeruginosa, and carbapenem-resistant Acinetobacter baumannii (regression coefficient > 0, P < 0.05). The average hospital stay had a positive effect on the isolation proportion for several antibiotic-resistant organisms, including methicillin-resistant Staphylococcus aureus, methicillin-resistant coagulase-negative Staphylococcus, vancomycin-resistant Enterococcus faecalis, vancomycin-resistant Enterococcus faecium, penicillin-resistant Streptococcus pneumoniae, cefotaxime or ceftriaxone resistant Escherichia coli, carbapenem-resistant Escherichia coli, quinolone-resistant Escherichia coli, cefotaxime or ceftriaxone resistant Klebsiella pneumoniae, carbapenem-resistant Pseudomonas aeruginosa, and carbapenem-resistant Acinetobacter baumannii (regression coefficient > 0, P < 0.05). Bed allocation and utilization efficiency in healthcare institutions may affect the isolation proportion of MDROs in varying degrees.
Metformin may improve the outcome of patients with colorectal cancer and type 2 diabetes mellitus partly through effects on neutrophil extracellular traps
Authors: Saito Akira , Koinuma Koji , Kawashima Rie , Miyato Hideyo , Ohzawa Hideyuki , Horie Hisanaga , Yamaguchi Hironori , Kawahira Hiroshi , Mimura Toshiki , Kitayama Joji , Sata Naohiro 
Published: December 2023

Abstract
Background
Although metformin reduces the risk of cancer-related mortality in patents with type 2 diabetes, the mechanism of its anti-cancer effects has not been fully understood.

Method
Impact of metformin on survival was examined in patients who underwent curative colectomy for colorectal cancer (CRC). The effects of metformin in neutrophil extracellular traps (NETs) were examined with in-vitro experiments and multiplex immunohistochemistry of surgically resected CRC specimens.

Results
Prior intake of metformin prolonged relapse-free (P = 0.036) and overall survival (P = 0.041) in 289 patients with T2DM to the comparable levels to those of 1576 non-diabetic patients. Metformin reduced the production of NETs stimulated with lipopolysaccharide or HT-29 colon cancer cells to 60% of control. Neutrophils markedly suppressed the chemotactic migration of activated T cells in an NET-dependent manner, which was reversed by metformin treatment up to approximately half of the migration without neutrophils. Immunohistochemical analysis revealed a significant association between metformin intake and a reduction in the numbers of tumor-associated neutrophils (TANs) and NETs. Simultaneously, metformin intake was found to increase the presence of CD3(+) and CD8(+) tumor-infiltrating T cells (TILs), particularly at the tumor-invasion front, especially in areas with fewer TANs and NETs.

Conclusion
Metformin suppresses the diabetes-associated enhancement of NET formation, which can augment the infiltration of TILs in CRC tissues. The anti-tumor effect of metformin in patients with T2DM may be, at least partly, attributable to the inhibition of NETs.
Ferrous–sucrose complex supplementation regulates maternal plasma metabolism and the fecal microbiota composition and improves neonatal immunity and placental glucose transportation by activating the EGF/PI3K/AKT signaling pathways in sows
Authors: Dong Zhenglin , Liu Hongwei , Wan Dan , Wu Xin , Yin Yulong 
Published: December 2023

Ferrous–sucrose complex supplementation regulates maternal plasma metabolism and the fecal microbiota composition and improves neonatal immunity and placental glucose transportation by activating the EGF/PI3K/AKT signaling pathways in sows.
Herausforderungen beim Stillen
Authors: Kerlen-Petri Katharina 
Published: December 2023

Stillwissen regelmäßig auffrischenDie Stillbegleitung ist ein wichtiger Teil der Hebammenarbeit und wir haben einen
Anteil daran, wie Frauen sich darauf vorbereiten, ob sie nach der Geburt einen guten
Start in die Stillbeziehung haben und ob sie der WHO-Empfehlung folgen
können, sechs Monate ausschließlich zu stillen. Laut der
KiGGS-Studie (Welle 2) gelingt dies nur bei etwa jedem achten Kind.
Cloud technology and capsule endoscopy: A single-center users’ experience of remote online video analysis and reporting
Authors: Costigan Conor , Walker Caroline , O'Connell Jim , Omallao Emmanuel , Manoharan Thilagaraj , Eagle Niamh , Bailey Yvonne , O'Hara Fintan , Mc Namara Deirdre 
Published: December 2023

Abstract
Background and study aims Telemedicine has progressed
significantly in recent years, with newer, more integrated information technology systems
improving healthcare delivery. The development of the world’s first cloud-based capsule
platform could allow safe and timely virtual analysis of videos from a network of linked
hospital centers. We aimed to assess the efficacy of Medtronic’s PillCam Remote Reader
System.
Methods PillCam remote reader technical data were collected from
the capsule endoscopy (CE) database over 8 months. User-reported performance was collect using
an online survey. Outcomes included overall procedure success, video-upload/report-download
rates and speeds, encryption/decryption rates, and user/reader satisfaction.
Results Data from 377 studies encompassing seven different
readers was collected (318 small bowel capsules, 59 colon capsules). Overall procedure success
was 100% (all videos reported). Two upload delays occurred (< 24 hours). There were no
encryption/decryption errors. Seven of seven respondents felt it easy to access and use vs one
of seve for the old system. Six of seven respondents felt department efficiency increased.
Benefits included off-site reading and multisite-conferences. Issues included offsite
difficulty accessing other hospital systems.
Conclusions PillCam remote reader is a reliable, secure, and
effective capsule analysis platform and should be incorporated into any CE service development
plan.