bluuebunny/crossref_metadata_2025_split huggingface dataset:
The Predictive Value of FDG PET/CT for Determining Progression-Free Survival in Advanced Stage III–IV BRAF-Mutated Melanoma Patients Treated With Targeted Therapy—What Can Be Learned From Progression?
Authors: van der Hiel Bernies , Aalbersberg Else A. , van den Eertwegh Alfons J.M. , de Wit-van der Veen Linda J. , Stokkel Marcel P.M. , Lopez-Yurda Marta , Boellaard Ronald , Kapiteijn Ellen W. , Hospers Geke A.P. , Aarts Maureen J.B. , de Vos Filip Y.F.L. , Boers-Sonderen Marye J. , van der Veldt Astrid A.M. , de Groot Jan Willem B. , Haanen John B.A.G 
Published: December 2023

Purpose
The aims of this study were to investigate whether (early) PERCIST response monitoring with 18F-FDG PET/CT is predictive for progression-free survival (PFS) in unresectable stage III or IV melanoma patients treated with BRAF/MEK inhibitor (MEKi) and to define dissemination patterns at progression with a lesion-based evaluation in direct comparison to baseline to improve our understanding of 18F-FDG PET/CT during BRAF/MEKi.

Patients and Methods
This prospective multicenter single-arm study included 70 patients with unresectable stage III/IV BRAF-mutated melanoma who underwent contrast-enhanced CT and 18F-FDG PET/CT at baseline and 2 and 7 weeks during treatment with vemurafenib plus cobimetinib and at progression if possible. Tumor response assessment was done with RECIST1.1 and PERCIST. Follow-up PET/CT scans were visually compared with baseline to assess dissemination patterns.

Results
Using RECIST1.1, PFS was not significantly different between the response groups (P = 0.26). At 2 weeks, PERCIST median PFS was 15.7 months for patients with complete metabolic response (CMR) versus 8.3 months for non-CMR (P = 0.035). The hazards ratio (HR) for progression/death in non-CMR versus CMR was 1.99 (95% confidence interval [CI], 1.03–3.84; P = 0.040) and 1.77 (95% CI, 0.91–3.43; P = 0.0935) when adjusting for lactate dehydrogenase (LDH). At 7 weeks, median PFS for PERCIST CMR was 16.7 months versus 8.5 months for non-CMR (P = 0.0003). The HR for progression/death in the non-CMR group was significantly increased (HR, 2.94; 95% CI, 1.60–5.40; P = 0.0005), even when adjusting for LDH (HR, 2.65; 95% CI, 1.43–4.91; P = 0.0020). At week 7, 18F-FDG PET/CT was false-positive in all 4 (6%) patients with new FDG-avid lesions but CMR of known metastases. When 18F-FDG PET/CT was performed at progressive disease, 18/22 (82%) patients had progression of known metastases with or without new 18F-FDG–avid lesions.

Conclusions
This study shows that PERCIST response assessment at week 7 is predictive for PFS, regardless of LDH. At 2 weeks, patients with CMR have longer PFS than patients with non-CMR, but different PET parameters should be investigated to further evaluate the added value of early 18F-FDG PET/CT. Disease progression on PET/CT is predominated by progression of known metastases, and new 18F-FDG–avid lesions during BRAF/MEKi are not automatically a sign of recurrent disease.
Central mechanisms of acupuncture in relieving visceral hypersensitivity in functional gastrointestinal disorders: A narrative review
Authors: Feng Bowen , Wang Yu , Rong Peijing 
Published: December 2023

Abstract
Visceral hypersensitivity (VH), one of the major symptoms of functional gastrointestinal disorders (FGIDs), impacts the social life and quality of life of the patients. Because of the complex pathological mechanism, the drug therapy for VH has unsatisfactory clinical efficacy and induces side effects. Alternative strategies acting on the central nervous system with few side effects are urgently needed. We summarize the central mechanisms of acupuncture in relieving VH to provide theoretical support for the clinical application of acupuncture in the treatment of VH in FGIDs. In this study, we retrieved the related articles from PubMed and Web of Science with the key words of “acupuncture,”“electroacupuncture,” and “visceral hypersensitivity.” According to the sensory conduction, perception, and emotion-related pathways involved in VH, we summarize the central mechanism of acupuncture in relieving VH from the perspectives of molecular biology and neuroimaging. The pathogenesis of VH in FGIDs involves the peripheral and central nervous systems, which are responsible for the transmission and perception of visceral sensations as well as the regulation of emotion. The widespread nature of VH indicates the involvement of the central nervous system. Acupuncture mediates the signaling pathways between the gastrointestinal tract and the brain to regulate gastrointestinal function and relieve VH. Acupuncture relieves VH by integrating multiple pathways and targets. The available studies in this field mainly focus on the regulation of a specific target or chemical transmitter by acupuncture, while the exact connection among these targets remains to be clarified by multilevel and multitarget studies.
Correlation Between Visual Acuity and Foveal Threshold by Automated Perimetry With Size V Stimulus
Authors: Bohm Parker E. , Stunkel Leanne , Van Stavern Gregory P. 
Published: December 2023

Background:
Visual acuity has been shown to correlate with foveal threshold as determined by automated perimetry. Although automated perimetry with size V stimulus is commonly used in neuro-ophthalmology practice, the relationship between the visual acuity and the foveal threshold with this larger stimulus is not well known.

Methods:
Retrospective study of patients who had undergone neuro-ophthalmology evaluation and visual field testing with automated perimetry using size V stimulus. Healthy controls were also recruited. Using visual acuity and foveal threshold, Pearson correlation coefficients were calculated, and basic foveal threshold statistics were stratified by visual acuity. Prediction intervals for visual acuities by various foveal threshold were also calculated.

Results:
A total of 106 unique eyes were included. The final Pearson correlation coefficient between visual acuities was −0.795 for the right eye and −0.578 for the left eye, with a pooled correlation coefficient of −0.751 (P < 0.001). A foveal threshold of at least 34 dB was present in 94.4% of eyes with 20/20 visual acuity, and a foveal threshold of greater than 35 dB was not observed in eyes with visual acuity of 20/40 or worse.

Conclusions:
Foveal threshold as determined by automated perimetry using size V stimulus has moderate-to-strong correlation with visual acuity in patients undergoing neuro-ophthalmology evaluation.
Predicting biomarker for the acute pulmonary embolism by using gene ontology and machine learning
Authors: Zhou Kun , Duan Hui , Chen Zhao , Hao Hu 
Published: December 2023

AbstractKey PointsEarly and Accurate Diagnosis Essential:Acute pulmonary embolism (PE) is a critical condition that demands prompt and precise diagnosis for effective treatment.Limitations of Current Diagnostics:Existing diagnostic methods like Computed Tomography Pulmonary Angiography (CTPA) have certain limitations, leading to the exploration of alternative approaches.Potential of Blood-Based Biomarkers:A recent study focused on identifying blood-based biomarkers for PE. This involved using gene ontology analysis and machine learning methods to analyze gene expression data from both PE patients and healthy controls.Gene Selection and Analysis:The study selected 20 genes for detailed analysis. These included various coagulation factors, fibrinolytic genes, and inflammation markers. Gene Ontology enrichment analysis was performed to understand the biological processes and molecular functions of these genes.Machine Learning for Diagnosis:Supervised machine learning algorithms were utilized to create classification models using the expression levels of these 20 genes. The models demonstrated promising results in distinguishing PE patients from healthy individuals.Acute pulmonary embolism (PE) is a life-threatening condition requiring early and accurate diagnosis. Current diagnostic methods like CTPA have limitations, and a study aimed to identify potential blood-based biomarkers for PE using gene ontology analysis and machine learning methods. Gene expression data of PE patients and healthy controls were obtained from the Gene Expression Omnibus database. A total of 20 genes were selected for further analysis, including coagulation factors F7, F10, F12, fibrinolytic genes PLAT, SERPINE1 and SERPINE2, and inflammation markers SELE, VCAM1 and ICAM. Gene Ontology enrichment analysis was performed to identify biological processes and molecular functions overrepresented among the candidate genes. Supervised machine learning algorithms were applied to build classification models using the expression levels of the 20 genes as features. Nested cross-validation was employed to assess model performance. The RF model achieved the highest area under the receiver operating characteristic curve of 0.89, indicating excellent discrimination between PE patients and controls based on the gene expression signature. Validation in larger cohorts is warranted to clinically translate these findings into a non-invasive diagnostic test for PE.
Relationship between trust, the investment model and logistics performance in supply chain management
Authors: Lee Changjoon , Ha Byoung-Chun 
Published: December 2023

PurposeThis study examines the relationship between trust, the investment model and logistics performance and the importance of commitment between companies in the supply chain. Furthermore, it analyzes satisfaction, quality of alternatives, investment size and commitment level, which are the constituent factors of the investment model, and reviews trust and logistics performance to ascertain their causal relationship.Design/methodology/approachThe authors examined employees working in supply chain-related departments in Korean companies and further conducted an online survey for a month in January 2022 through the survey agency Entrust Survey, through which the authors distributed a total of 4,082 questionnaires and collected and used a total of 300 questionnaires for statistical analysis. The authors then validated the hypotheses using SPSS 18.0 and AMOS 18.0 using the structural equation modeling method.FindingsThe results showed that trust significantly and positively affects satisfaction levels in the relationship between companies in the supply chain. Trust can lower uncertainty in the transaction process between companies.Originality/valueIn this study, the investment model, which has been predominantly observed in the field of family psychology, was applied to business studies. In addition, the investment model was extended to enable its application to supply chain management research, thereby offering a distinctive research model from preceding studies.
Entrepreneurial intention among women entrepreneurs and the mediating effect of dynamic capabilities: empirical evidence from Lebanon
Authors: Nigam Nirjhar , Shatila Khodor 
Published: December 2023

PurposeEntrepreneurship institutions exhibit substantial gender discrimination despite worldwide efforts to decrease the phenomenon. The MENA area has a low percentage of women entrepreneurs since little is known about women’s desire to start their businesses. The authors use the theory of planned behavior (TPB) to explain what influences women's propensity toward entrepreneurship and what factors discourage them.Design/methodology/approach TPB is a psychological theory explaining how individuals act in certain situations. The authors created their database by using a systematic questionnaire. Overall, 350 women entrepreneurs contributed to their dataset. Finally, the authors used structural equation modeling to verify their hypotheses.FindingsThis study helps them to shed light to better understand the dynamics of Entrepreneurial Intention, in women from Lebanon. The authors do not find any relationship between lack of knowledge, funding, networking and entrepreneurial startup intention for Lebanese women. The role of dynamic capabilities in the entrepreneurial landscape of Lebanon, particularly for women, is substantially highlighted by the full mediation observed in the relationship between lack of knowledge and entrepreneurial start-up intentions. The findings discovered that these capabilities could fully mediate the negative impact of lack of networking on the intention to commence entrepreneurial ventures.Originality/valueThis research illustrates and explains how dynamic capabilities mediate the relationship between women entrepreneurs' challenges and their intention to start a business in the Lebanese context.
Reinforcing sustainable consumption practices through promoting gastronomic tourism: a cross-sectional study from India and Bangladesh
Authors: Samaddar Kaushik , Mondal Sanjana 
Published: December 2023

Purpose
Food not only satisfies the need and nourishes positive experiences but also enhances involvement with the cultural, social and environmental attributes of a destination. As urban tourism is embracing sustainable consumption practices (SCP), this study aims to explore tourist’s responsible behaviour by embracing traditional gastronomic delicacies. More specifically, it pinpoints the driving forces behind why people choose traditional gastronomic delights.

Design/methodology/approach
The study adopted the triangulation method involving the grounded theory approach (GTA) attained through a series of focus group discussions followed by the survey method taking an emerging economy’s perspective (India and Bangladesh). This study accords equal importance to both the demand and supply perspectives of gastronomic tourism and its stakeholders.

Findings
Critical dimensions such as travel motivation, tourist expectations, socio-economic perspectives, mindful consumption, sustainable marketing efforts and community awareness were identified as major influencers towards traditional gastronomic delicacies.

Practical implications
The present study bears significance to the urban developers, policymakers, marketers, regional tourism bodies and tour operators in promoting urban gastronomic cultures through marketing traditional delicacies for sustainable development of the evolving gastronomic industry in India and Bangladesh.

Originality/value
This study makes a novel attempt in exploring critical dimensions in an evolving gastronomic industry by blending an innovative qualitative research methodology like GTA supported by the empirical validation process (quantitative). It proposes a theoretical framework for further advancement of gastronomic and urban tourism towards a SCP.
Top management characteristics and comprehensive focus on budgeting
Authors: Kihn Lili-Anne , Ström Eva 
Published: December 2023

PurposeThis study examines how the strong emphasis placed on the purposes of budgeting, referring to a comprehensive focus on budgeting, is related to top managers' education and tenure while controlling for their functional positions in their respective firms and ages, as well as several company-specific predictors (information quality, firm size, information technology, importance of profit and strategy).Design/methodology/approachSurvey data were collected from senior managers of large manufacturing firms in Finland and Sweden.FindingsThe results suggest that academic business education is positively associated with a comprehensive focus on budgeting, but tenure as well as functional position in the company (Chief Financial Officer (CFO) or not) and age are not. Overall, the company-specific control variables in general and information quality in particular are shown to have greater explanatory power than the top management characteristics analyzed.Research limitations/implicationsThis study identifies several empirically supported factors that seem to contribute to a comprehensive focus on budgeting. The effects of information quality, business education, the importance of profit and firm size could be considered in future research.Practical implicationsAcademic business education matters more than the other top management characteristics analyzed. If organizations want to make comprehensive use of budgets, they should employ business graduates and be mindful of company-specific variables.Originality/valueThis study is the first to address a comprehensive focus on budgeting and some of its determinants. Future research could investigate a broader set of such determinants in different contexts.
Critical application areas of radio frequency identification (RFID) technology for sustainable construction in developing countries: the case of Nigeria
Authors: Kineber Ahmed Farouk , Oke Ayodeji Emmanuel , Ali Ali Hassan , Dosumu Oluwaseun , Fakunle Kayode , Olanrewaju Oludolapo Ibrahim 
Published: December 2023

Purpose
This study aims to explore the critical application areas of radio frequency identification (RFID) technology for sustainable buildings.

Design/methodology/approach
The quantitative research approach was adopted through a structured questionnaire administered to relevant stakeholders of construction projects. The data collected were analysed with the exploratory factor analysis, relative importance index (RII) and fuzzy synthetic evaluation (FSE).

Findings
The study’s results have categorised the crucial areas of application where construction industry stakeholders should focus their attention. These areas are divided into four categories: management technologies, production technologies, sensing technologies and monitoring technologies. The findings from the FSE indicate that monitoring technologies represent the most significant category, whereas management technologies rank as the least significant. Moreover, the RII analysis highlights that tools management stands out as the most important application of RFID, while dispute resolution emerges as the least significant RFID application.

Practical implications
The study establishes the core areas of RFID application and their benefits to sustainable buildings. Consequently, it helps stakeholders (consultants, clients and contractors) to examine the RFID application areas and make informed decision on sustainable construction. Furthermore, it provides systematic proof that can aid the implementation of RFID in developing countries.

Originality/value
The study provides an insight into the possible application areas and benefits of RFID technology in the construction industry of developing countries. It also developed a conceptual frame for the critical application areas of RFID technology in the construction industry of developing countries.
Enhanced-pixel strategy for wire arc additive manufacturing trajectory planning: operational efficiency and effectiveness analyses
Authors: Ferreira Rafael Pereira , Vilarinho Louriel Oliveira , Scotti Americo 
Published: December 2023

Purpose
This study aims to propose and evaluate the progress in the basic-pixel (a strategy to generate continuous trajectories that fill out the entire surface) algorithm towards performance gain. The objective is also to investigate the operational efficiency and effectiveness of an enhanced version compared with conventional strategies.

Design/methodology/approach
For the first objective, the proposed methodology is to apply the improvements proposed in the basic-pixel strategy, test it on three demonstrative parts and statistically evaluate the performance using the distance trajectory criterion. For the second objective, the enhanced-pixel strategy is compared with conventional strategies in terms of trajectory distance, build time and the number of arcs starts and stops (operational efficiency) and targeting the nominal geometry of a part (operational effectiveness).

Findings
The results showed that the improvements proposed to the basic-pixel strategy could generate continuous trajectories with shorter distances and comparable building times (operational efficiency). Regarding operational effectiveness, the parts built by the enhanced-pixel strategy presented lower dimensional deviation than the other strategies studied. Therefore, the enhanced-pixel strategy appears to be a good candidate for building more complex printable parts and delivering operational efficiency and effectiveness.

Originality/value
This paper presents an evolution of the basic-pixel strategy (a space-filling strategy) with the introduction of new elements in the algorithm and proves the improvement of the strategy’s performance with this. An interesting comparison is also presented in terms of operational efficiency and effectiveness between the enhanced-pixel strategy and conventional strategies.
Trade-offs in stakeholder theory: an ordonomic perspective
Authors: Pies Ingo , Valentinov Vladislav 
Published: December 2023

Purpose
Stakeholder theory understands business in terms of relationships among stakeholders whose interests are mainly joint but may be occasionally conflicting. In the latter case, managers may need to make trade-offs between these interests. The purpose of this paper is to explore the nature of managerial decision-making about these trade-offs.

Design/methodology/approach
This paper draws on the ordonomic approach which sees business life to be rife with social dilemmas and locates the role of stakeholders in harnessing or resolving these dilemmas through engagement in rule-finding and rule-setting processes.

Findings
The ordonomic approach suggests that stakeholder interests trade-offs ought to be neither ignored nor avoided, but rather embraced and welcomed as an opportunity for bringing to fruition the joint interest of stakeholders in playing a better game of business. Stakeholders are shown to bear responsibility for overcoming the perceived trade-offs through the institutional management of social dilemmas.

Originality/value
For many stakeholder theorists, the nature of managerial decision-making about trade-offs between conflicting stakeholder interests and the nature of trade-offs themselves have been a long-standing point of contention. The paper shows that trade-offs may be useful for the value creation process and explicitly discusses managerial strategies for dealing with them.
Unveiling the path to sustainable quality 4.0 implementation in organisations: insights from an exploratory qualitative study
Authors: Swarnakar Vikas , McDermott Olivia , Sony Michael , Bhat Shreeranga , Antony Jiju 
Published: December 2023

PurposeThis study investigates the challenges and opportunities that organisations face in implementing Quality 4.0 as an approach to quality management and investigate the current state of Quality 4.0 implementation.Design/methodology/approachThis study uses a qualitative research methodology to interview senior managers from globally based manufacturing and service industries.FindingsThe study explicates that most organisations implemented Quality 4.0 to improve their flexibility, efficiency, transparency and productivity while focusing on improving service quality, customer satisfaction and reducing cost. In terms of sustainability of Quality 4.0 the key factors found were a consistent effort from the top management, continuous training to employees, building leadership quality and creating a habit of using Quality 4.0.Practical implicationsThe findings of this study offer useful guidance to organisations desirous of implementing Quality 4.0. In addition, the findings have identified key sustainability factors, helping organisations ensure a successful implementation and long-term returns from Quality 4.0.Originality/valueThe findings of this study contribute to the body of knowledge related to Quality 4.0 and help organisations in their digital transformation journey. In addition, it is one of the first studies to investigate the key factors for Quality 4.0 sustainability.