bluuebunny/crossref_metadata_2025_split huggingface dataset:
Changing Trends in the Penile Prothesis Implantation of male with refractory Erectile Dysfunction in China
Authors: Zhang Chenwang , Bai Haowei , shi Chenkun , Chen Huirong , LI Peng , Huang Yuhua , chen huixing , Zhao Fujun , Yao Chencheng , Li Zheng , Zhi ER LEI 
Published: February 2024

Abstract

Background
This study aims to investigate the changing trends in the penile prothesis implantation(PPI) of male with refractory erectile dysfunction(ED) in China.
Method
We retrospectively reviewed medical records from January 2019 to October 2023 to identify men who had undergone PPI in China. We also retrospectively reviewed medical records of PPI we had undergone during that time at Shanghai General Hospital.
Results
The overall trajectory of PPI surgeries exhibits an upward trend in China. Concurrently, the expertise in this surgical technique is currently limited to a minority of surgeons. A total of 112 patients were included in the study. Median age was 39[27–63] years, median International Index of Erectile Function-5 score (IIEF-5) significantly improved from 10.23 ± 1.26 to 22.6 ± 2.73. The causes of severe ED were: vasculogenic tower (n = 58, 51.8%), diabetes (n = 21,18.8%) and pelvic/spinal cord injury (n = 14, 12.5%). Overall satisfaction rate for the PPI surgery was 93.0% for men and 90.4% for their partners. The 3-year PPI survival rate was 87%.
Conclusion
The prevalence of PPI has witnessed a steady increase since 2019 in China, indicating a growing acceptance and endorsement of this surgical intervention among both patients and andrological practitioners for the treatment of severe ED. PPI is a safe and effective treatment option for Chinese patients with refractory ED and experienced surgeon perform PPI according to standard PPI procedure could reduce the complications and improve sexual satisfaction of patients and sexual partners .
Raw Milk Quality and Handling Practices by Pastoral Communities at Cattle Camps in Rejaf East, South Sudan
Authors: Aguer Elijah Majok Kiir , Augustino Serafino Musa Abdelkarim , Rapheal Wangalwa , Jeninah Atwebembeire 
Published: February 2024

Abstract

Food safety including imported food and produced food, is a major issue for South Sudan. An effective safety food control system for guiding and eliminating hazardous food from the market is lacking. Milk is one of the food products consumed in South Sudan; however, there is limited information regarding its handling and safety, especially among pastoral communities. Therefore, this study assessed raw milk quality and handling practices by pastoral communities at cattle camps in the Rejaf East, South Sudan. The study was conducted in three cattle camps (Highland, Kadoro, and Jebel Amianin) of the Rejaf East. Raw milk handling practices in the cattle camps were assessed using a questionnaire and observation checklist among 240 households selected randomly. The physicochemical and microbial parameters were assessed in 75 samples of raw milk using standard methods. The findings revealed that milking handling practices at cattle camps are characterized by hygienic and unhygienic practices. The pastoral communities had no access to a cooling system for milk storage. Additionally, 90.8% of the households in cattle camps consumed unboiled raw milk, and 10% of the households experienced milk rejection at the point of milk sale. The overall means of the physicochemical parameters of the milk samples were as follows: fat = 7.76 ± 1.47%, SNF = 7.68 ± 0.26%, density = 1.03 ± 0.00 g/ml, lactose = 4.21 ± 0.15%, protein = 2.81 ± 0.09%, freezing point = -0.51 ± 0.030C, and pH 6.60 ± 0.21. The results of the microbiological quality of the raw milk indicated that the highest TVC (5.81 ± 0.51 logCFU/ml) was recorded in Jebel Amianin; on the other hand, the highest TCC (4.64 ± 0.21 logCFU/ml) was recorded in Kadoro, and the highest TSC (2.53 ± 0.31 logCFU/ml) was recorded in Highland Boma. The study indicated that pastoralists in cattle camps do not observe hygienic practices, including drying hands after handwashing or washing with udder and teats before milking. Furthermore, the study showed that the microbiological quality of raw milk samples obtained from the Rejaf East has a high bacterial load; therefore, there is a need to improve hygiene practices in milk production.
Investigation and correlation analysis of financial toxicity and risk of suicide in the patients with head and neck cancer in China
Authors: Sun Meng-chen , Feng Fang-ming , Wang Xiu-yu , Yang Fang-fang , Zhao Mei-hui , Meng Jing 
Published: February 2024

Abstract

Background
To understand the current state of financial toxicity and suicide risk in head and neck cancer patients,to investigate the correlation between the level of financial toxicity and suicide risk in head and neck cancer patients,and to provide a basis for reducing the level of financial toxicity and the risk of suicide in head and neck cancer patients.
Methods
A cross-sectional survey was conducted,from March 1 to July 31,2022,150 head and neck cancer patients were selected from Oncology Department of East Hospital Affiliated to Tongji University by convenient sampling method.The survey was carried out by means of the general questionnaire,Comprehensive Score for Financial Toxicity based on the Patient-Report Outcome Measures(COST-PROM),Cancer Suicide Risk Scale(CSRS),and then analysis the datum.
Results
The score of COST-FROM of 150 head and neck cancer patients was (18.00±6.12) points,and the score of CSRS of head and neck cancer patients was (36.31±8.51) points.The total score of economic toxicity was significantly negatively correlated with the total score of suicide risk and its dimensions (r values were − 0.446 to 0.235,all P<0.05).The total score of suicide risk was negatively correlated with the total score of economic toxicity and the scores of each dimension (r values were − 0.446 to -0.251,all P<0.05).
Conclusion
Patients with head and neck cancer were at higher risk of suicide,and financial toxicity was a significant contributing factor to suicide risk,with higher levels of financial toxicity associated with a higher risk of suicide.Reducing the level of financial toxicity in patients with head and neck cancer has important implications for reducing their risk of suicide.
Importance of standard precautions to febrile neutropenia prevention in patients with cancer during COVID 19 outbreak
Authors: Park Ji Eun , Yang Jieun , Han Sanghoon , Hana Chi Wha , Yoo Jeong Rae , Kim Misun , Lee Donghyoun , Jo Jaemin 
Published: February 2024

Abstract
Purpose
Intensive cytotoxic chemotherapy increases the risk of infection in patients with cancer by inducing bone marrow suppression and mucosal injury. Febrile neutropenia (FN) is the most important clinical adverse event in patients with cancer who receiving cytotoxic chemotherapy. To prevent FN, prophylactic antibiotics, colony stimulating factors (CSFs) and also standard precautions including hand and respiratory hygiene are generally recommended but the exact effect of non-pharmacologic intervention such as standard precaution has not been clearly proven in the clinical setting. we aimed to compare the incidence of FN between pre-coronavirus disease 19 (COVID 19) era versus post-COVID 19 era.
Material and methods
We retrospectively enrolled patients with breast cancer who received adjuvant adriamycin and cyclosphosphamide (AC) chemotherapy at Jeju national university hospital.
Results
In total, 149 patients well enrolled, including 94 who received AC chemotherapy in pre-COVDI 19 era and 55 who received at post-COVID 19 era. Sixteen (10.7%) patients experienced the FN. Fourteen events (14.9%) and two events (3.6%) were occurred in pre-COVID 19 and post-COVDI 19 era, respectively. The post-COVID 19 era was the only risk factor for FN. (p = 0.032)
Conclusion
We found an association between FN occurrence and COVID 19 outbreak; thus, providing indirect evidence of the importance of non-pharmacological measure to reduce FN risk in patients with cancer. Further research is required to confirm the standard precautions for FN prevention in patients with cancer.
Experimental study on visualization of seepage flow and grout diffusion and seepage reduction patterns in rough single fissure
Authors: Tan Chunzhi , Qian ziwei , Wang bingzhu 
Published: February 2024

Abstract

The study of fissure seepage and grouting diffusion, seepage reduction law is of great significance for the prevention and control of water damage in fissured rock bodies. To this end, a visualization test model based on the morphology of real rock fissures was prepared in bulk using 3D scanning and 3D printing technology, and tests were carried out to realize the visualization of seepage flow in a single fissure, grouting with different water-cement ratios, and seepage flow after the fissure grouting was consolidated and filled. The test results show that: compared with grouting diffusion, the seepage of water injection into the fissure is different in activity and coverage; the rough single fissure seepage shows nonlinear flow characteristics, and is a composite flow form of laminar and turbulent flow; the grouting into the fissure has the effect of climbing and swooping, and the diffusion rate and filling rate of the grout are obviously different under different water-cement ratio conditions; after the grout is filled and consolidated in the fissure, the permeability coefficient of the fissure is greatly reduced, and the seepage performance is significantly different. After the slurry is filled and consolidated in the fissure, the permeability coefficient is greatly reduced, and the seepage flow is nonlinear, which conforms to the Forchheimer's equation, and with the decrease of the water-cement ratio of the cement slurry, the coefficient of the linear term decreases, and the coefficient of the nonlinear term increases and accounts for a larger proportion in the binomial.
WITHDRAWN: Clinical characterization and immunosuppressive regulation of DNAJCB5B in Esophageal Squamous Cell Carcinoma
Authors: Hu Junxi , Xu Jinye , Tian Shuyu , Zhang Dong , Wang Xiaolin , Shu Yusheng 
Published: February 2024

Abstract

Background DnaJ Homolog Subfamily C Member 5B (DNAJC5B), as a member of the heat shock protein family, has not yet been fully clarified in its role in tumor development, making it particularly important to study its potential role in the immunotherapy of esophageal cancer.
Methods This study utilized the esophageal cancer dataset from the TCGA database, selecting genes associated with DNAJC5B expression through Pearson correlation analysis, followed by Gene Ontology (GO) functional enrichment analysis and KEGG pathway analysis. Additionally, single-cell RNA sequencing data was used to analyze DNAJC5B expression in different T cell subgroups. The prognostic value of DNAJC5B was evaluated using Kaplan-Meier survival curves, receiver operating characteristic (ROC) curves, and Cox proportional hazards model analysis.
Results DNAJC5B is highly expressed in patients with advanced esophageal cancer, especially in males. Immunohistochemical staining results indicate a notable enrichment of DNAJC5B in the cytoplasm of cancer tissue cells. GO and KEGG analysis indicated significant correlations between DNAJC5B expression and immune-related processes like adaptive immune response and cell surface receptor signaling pathways. Single-cell analysis showed that DNAJC5B predominantly accumulates in CD8+ T cells and is associated with cell activation state. Survival analysis indicated that patients with high DNAJC5B expression had a median survival of 681 days, markedly lower than the 1361 days in those with low expression. Both univariate and multivariate Cox proportional hazards model analyses identified DNAJC5B as an independent prognostic factor in ESCC patients.
Conclusion This study suggests that DNAJC5B may play a significant immunomodulatory role in esophageal cancer, particularly in regulating CD8+ T cell function and tumor immune escape. These findings support the potential of DNAJC5B as a biomarker for treatment and prognosis evaluation in esophageal cancer, providing new strategic directions for immunotherapy of esophageal cancer.
Combined biological effects of CBCT and therapeutic X-ray dose on chromosomal aberrations of lymphocytes
Authors: Gáldi Ádám , Farkas Gyöngyi , Hegyesi Szilvia Gazdag , Koszta Enikő , Ágoston Péter , Pesznyák Csilla , Major Tibor , Takácsi-Nagy Zoltán , Polgár Csaba , Jurányi Zsolt 
Published: February 2024

Abstract

Background and purpose: Cone Beam Computed Tomography (CBCT) is routinely used in radiotherapy to localize target volume. The aim of our study was to determine the biological effects of CBCT dose compared to subsequent therapeutic dose by using in vitro chromosome dosimetry.
Materials and methods: Peripheral blood samples from five healthy volunteers were irradiated in two phantoms (water filled in-house made cylindrical, and Pure Image CTDI phantoms) with 6 MV FFF X-ray photons, the dose rate was 800 MU/min and the absorbed doses ranged from 0.5 Gy to 8 Gy. Irradiation was performed with a 6 MV linear accelerator (LINAC) to generate a dose-response calibration curve. In the first part of the investigation, 1-5 CBCT imaging was used, in the second, only 2 Gy doses were delivered with a LINAC, and then, in the third part, a combination of CBCT and 2 Gy irradiation was performed mimicking online adapted radiotherapy treatment. Metaphases were prepared from lymphocyte cultures, using standard cytogenetic techniques, and chromosomal aberrations were evaluated. Estimate doses were calculated from chromosome aberrations using dose-response curves.
Results: Samples exposed to X-ray from CBCT imaging prior to treatment exhibited higher chromosomal aberrations and Estimate dose than the 2 Gy therapeutic (real) dose, and the magnitude of the increase depended on the number of CBCTs: 1-5 CBCT corresponded to 0.04-0.92 Gy, 1 CBCT+ 2 Gy to 2.32 Gy, and 5 CBCTs + 2 Gy to 3.5 Gy
Conclusion: The estimated dose based on chromosomal aberrations is 24.8 % higher than the physical dose, for the combination of 3 CBCTs and the therapeutic 2Gy dose, which should be taken into account when calculating the total therapeutic dose that could increase the risk of a second cancer. The clinical implications of the combined radiation effect may require further investigation.
Shoreline change assessment and Wave Modeling on the Mostaganem Coast, Algeria
Authors: sallaye miloud , Dahmani Abd El Alim , cherif Youssra salem , Mezouar Khoudir 
Published: February 2024

Abstract
The coastal area of Sidi Madjedoub East to Oureah West is a very interesting and remarkable place. In the last 20 years, it is exposed to a series of natural and anthropogenic processes that generate short and long time variation. This research is based on the spatial-temporal analysis of the shoreline change along the coast between Sidi Madjedoub to Oureah, by using aerial photographs (2003) and quick-bird satellite images (2014 and 2023). The shoreline changes were calculated on 720 transects generated at intervals of 20 m. The Digital Shoreline Analysis System (DSAS) was used on the modelled shoreline. The results reveal that most of the area studied is undergoing erosion, with a mean rate change of -0.28 meters per year for the whole coast. In addition, numerical modelling of wave propagation was applied out using the Mike 21 model to get a better understanding of the influence of coastal hydrodynamics to shoreline change. This change in shoreline is principally due to human activities (sand mining, urbanization) and natural factors (currents, waves, storms). We can conclude that coastal morphology and the erosion and accretion of coastal zones are influenced by both natural and human activities.
MR-Compatible Tactile Stimulator System: Application for Individuals with Brain Injuries
Authors: KalantaryArdebily Nahid , Feldbush Anna C. , Gurari Netta 
Published: February 2024

Abstract
Accurate perception of tactile information is essential for performing activities of daily living and learning new sensorimotor skills like writing. Deficits in perceiving tactile stimuli are associated with severity in physical disability. The mechanisms contributing to tactile deficits in individuals with brain injuries remain poorly understood in part due to insufficient assessment methods. Here, we provide a tactile stimulator system for studying the neural mechanisms contributing to tactile deficits in individuals with brain injuries during functional magnetic resonance imaging (fMRI). This tactile stimulator system consists of a pneumatically-controlled inflatable and deflatable balloon that interfaces with a digit of the hand to provide small forces. The magnitude of the applied force is delivered and controlled by modifying the air pressure in the balloon. The tactile simulator provides an 8,mm diameter tactile stimulus. The device's interface at the finger is compact, allowing it to be used with individuals who have a closed-fist posture following brain injury such as stroke or cerebral palsy. The tactile stimulator contains no metallic components and can be used in MRI research. The tactile stimulator system can repeatedly apply a force between 1,N and 2.4,N. This tactile stimulator system addresses limitations in past fMRI methodologies for assessing tactile perception by providing precise and repeatable force stimuli to a small area of the finger. Custom software automates the application of the force stimuli and permits synchronization with acquired fMRI data. This system can be used in subsequent testing to investigate deficits in sensory functioning in those with brain injuries.
The Conceptualization of Cardiometabolic Disease Policy Model in the UK
Authors: Putri Septiara , Ciminata Giorgio , Lewsey Jim , Jani Bhautesh , McMeekin Nicola , Geue Claudia 
Published: February 2024

Abstract

Background
Decision models are increasingly used to inform the policy-making processes, and there is a need to improve their credibility. The estimation of health and economic outcomes generated from the decision models is influenced by the development process itself. This paper aims to present the conceptual model development process of cardiometabolic disease (CMD) policy models in the UK setting.
Methods
This conceptual model followed the International Society of Pharmacoeconomics and Outcomes Research-Society of Medical Decision Making (ISPOR-SMDM) Modelling Good Research Practices Task Force-2.
Results
First, for the conceptualization of the problem, the CMD disease staging, progression, and current clinical guidelines are summarized. We critically appraised published CMD models such as cardiovascular disease (CVD) and type 2 diabetes (T2DM). Key challenges of the modelling from this review include the importance of understanding complex risk factors, the economic perspective used, the need to improve the validation process of the state transition model, model structure, and assumptions. Second, as a sequential process, is model conceptualization, to determine which modelling types and their attributes best represent the defined problem. Expert opinions, including a clinician and experienced modellers, provided some input on the state transition model to ensure the structure is clinically relevant. From this stage, Atrial Fibrillation (AF) is considered as a potential covariate, removing further complication state for T2DM, and reconsidering myocardial infarction (MI) as a CHD state.
Conclusion
This conceptual model serves as a basis for representing the systematic process for structuring the CMD policy model to enhance its transparency and credibility.
Estimating Carrier Rates and Prevalence of Porphyria-Associated Gene Variants in the Chinese Population Based on Genetic Databases
Authors: Wang Yi Nan , Li Nuo Ya , Zhang Song Yun 
Published: February 2024

Abstract

Porphyria is a group of rare metabolic disorders caused by mutations in genes that encode crucial enzymes in the heme biosynthetic pathway. However, the lack of comprehensive genetic analysis of porphyria in the Chinese population makes it challenging to identify and diagnose carriers of the condition. Using the ChinaMAP database, we determined the frequencies of P/LP porphyria-associated gene variants according to the ACMG guidelines. We also calculated the carrier rates and prevalence for each type of porphyria in the Chinese population under the Hardy-Weinberg equilibrium (HWE). Compared with the gnomAD database, the genetic spectrum of porphyria-related P/LP variants in the Chinese population is distinct. In the ChinaMAP database, we identified 23 of these variants. We estimated the carrier rates for autosomal dominant porphyria (AIP, HCP, VP, PCT) in the Chinese population to be 1/1059, 1/1513, 1/10588, and 1/1765, respectively. For autosomal recessive porphyria (ADP, EPP, HEP, CEP), we estimated carrier rates of 1/5294, 1/2117, 1/1765, and 1/2647, with predicted prevalence rates of 1/112105744, 1/13312, 1/12456194, and 1/28026436, respectively. Notably, 12 of the variants we identified were unique to the Chinese population. The predicted prevalence rate of EPP is the highest among the various types of porphyria in the Chinese population, while the others are moderate to low. This study is the initial comprehensive genetic research on porphyria in the Chinese population. By outlining the genetic characteristics of various porphyria types among the Chinese, it provides scientifically sound reference data necessary for both research and genetic screening to identify porphyria carriers.
Impact Of KPD and NRG Flavonoids On Neurotoxicity Prompted By Aluminum Chloride Through Hindrance Of Oxidative Pressure : In Vivo Model
Authors: Nalla Swathi , Ganta Suhasin , Bukke Sarad Pawar Naik , Bandaru Nagaraju 
Published: February 2024

Abstract
Background:
The incidence of neurodegenerative diseases has skyrocketed alongside the extension of the average human lifespan. Oxidative stress is a hallmark of this group of diseases, its involvement in disease onset and/or progression is incompletely understood. Polyphenols are among the most promising natural compounds for their neuroprotective capabilities due to their distinctive chemical characteristics. So, it's exciting to look at the possibility of using new compounds with polyphenol qualities as neuroprotective. The goal of this study was to test the neuroprotective effect of the polyphenolic flavanol molecules Kaempferide and Norbergenin, in-vivo disease models generated by Aluminium chloride (AlCl3).
Results:
Therefore, this study was evaluated to estimate the alleviative effect of KPD and NRG against AlCl3 Induced neurotoxicity in rats. KPD (10 mgkg-1) and NRG (10 mgkg-1) supplemented group decreased the production of Amyloid and Tau Proteins. The anti-oxidants i.e., catalase (CAT), glutathione reductase (GSR), superoxide dismutase (SOD) and glutathione peroxidase (GPx) activities were reduced, besides malondialdehyde (MDA) & reactive oxygen species (ROS) contents were substantially (P < 0.05) elevated. Western blot analysis was performed AlCl3 exposure also prompted remarkable histopathological alterations in Brain tissues.
Conclusion:
KPD and NRG therapy, protect all the brain tissues from the damages induced byAlCl3. The findings of our study demonstrated that KPD can efficiently exerts protective effect due to its anti-oxidant, & neuroprotective effect.