bluuebunny/crossref_metadata_2025_split huggingface dataset:
A high-resolution bovine mitochondrial co-expression network
Authors: Alexandre Pâmela A. , Keogh Kate , Reverter Antonio , Hudson Nicholas J. 
Published: February 2025

ABSTRACT
The mitochondrion is a sophisticated, versatile, and dynamic organelle whose function is incompletely understood. Intending to provide a framework for mitochondrial visualisation and interpretation of genome-wide molecular data, we reverse-engineered a co-expression network whose final structure represented mRNA encoding more than half of the entire mitochondrial proteome. We drew upon 723 RNA-seq data sets representing 91 tissues and cell types from 441 individual cattle. A mitochondrial landscape was formed comprising a main network and many smaller sub-networks. One of the discrete sub-networks contains all 13 mRNA (e.g. MT-ND1, MT -CYTB, MT -COX2, MT -ATP8) plus 15/22 tRNA (e.g. MT-TT) encoded by the mt-genome itself, indicating some independent regulation from the nuclear genome with whom it must cooperate. Intriguingly, this mtDNA sub-network also contains a single nuclear-encoded gene, that of PDHA1. PDHA1 encodes a subunit of the pyruvate dehydrogenase complex that governs the conversion of pyruvate to Acetyl CoA. This enzyme is extremely influential, representing the fundamental cellular connection between the ancient, conserved pathway of glycolysis that occurs exclusively in the cytoplasm, and the TCA cycle that occurs within the mitochondrial matrix. To demonstrate the downstream utility of our approach, we overlaid Longissimus dorsi muscle transcriptome data from differentially feed efficient Charolais and Holstein Friesian cattle. This approach highlighted expression patterns sensitive to both breed and diet in a complex manner. An analytic advantage of this approach is that relatively subtle (&lt;2-fold) but coordinated changes that may be overlooked by conventional gene-by-gene significance testing become readily apparent. Finally, intending to understand the transcriptional regulation of mitochondrial function more thoroughly, we engineered a network built with transcription factors in addition to those mRNA encoding mitochondrial proteins. Here, a set of influential nuclear hormone receptors (e.g. PPARA) are enriched among the most highly and/or well-connected TF.
Leisure Physical Activity, Sedentary Behavior, and Cardiovascular Health 2-7 Years after Pregnancy in the nuMoM2b HHS Cohort
Authors: Gibbs Bethany Barone , Modlin Sarah , Merz Noel Bairey , Haas David M. , Khan Sadiya S. , Lane Abbi , McNeil Rebecca B. , Varagic Jasmina , Huber Kimberly , Vasquez-Huot Ligia , Catov Janet M. ,   for the National Heart, Lung, and Blood Institute nuMoM2b Heart Health Study Network
Published: February 2025

ABSTRACT

Purpose
To evaluate whether higher moderate-to-vigorous intensity physical activity (MVPA) and lower sedentary behavior (SB) are related to better cardiovascular health (CVH) following pregnancy.

Methods
In the nuMoM2b Heart Health Study (HHS) cohort, Life’s Essential 8 health factors (BMI, blood pressure, glucose, and lipid) were assessed in the first trimester of pregnancy and 2-7 years later (n = 3,985). The four health factors were scored with Life’s Essential 8 criteria (0 = poorest; 100 = ideal) and averaged to calculate a CVH health factor score (CVHhf
). Self-reported leisure MVPA and SB were assessed at follow-up. Linear regression evaluated associations of MVPA levels and SB quartiles with follow-up CVHhf after adjustment for first trimester CVHhf and covariates. Analyses were repeated after stratification by history of hypertensive disorders of pregnancy (HDP) or gestational diabetes (GDM).

Results
Over follow-up (mean 3.2 years after delivery), CVHhf declined from 85.6 to 81.6 points (-4.0 points, p < 0.001). The decline was greatest in lipid (-8.4 points, p < 0.001) and BMI scores (-5.6 points, p < 0.001). Healthier activity profiles (higher MVPA level and lower SB quartile) were each associated with higher CVHhf at follow-up: 0.7 points higher per level of MVPA, p < 0.001; 0.5 points lower per quartile of SB, p = 0.0042. Higher MVPA level associated with healthier BMI, glucose, and lipid scores; lower SB quartile associated with healthier BMI and blood pressure scores (p < 0.05). Although HDP/GDM history was associated with lower CVHhf, patterns of CVHhf across healthier leisure MVPA levels and SB quartiles were similar in those with and without HDP or GDM.

Conclusions
Higher MVPA and lower SB during leisure could help to maintain CVH health factors in the years following pregnancy, including among those who experienced HDP or GDM.
Ice Slurry Mitigates Hyperventilation and Cerebral Hypoperfusion, and May Enhance Endurance Performance in the Heat
Authors: Katagiri Akira , Kawai Syuntaro , Nishiyasu Takeshi , Fujii Naoto 
Published: February 2025

ABSTRACT

Purpose
Hyperthermia causes hyperventilation and associated cerebral hypoperfusion, both of which may limit endurance performance in the heat. Here, we investigated the hypothesis that pre-exercise ice slurry ingestion may mitigate hyperventilation and cerebral hypoperfusion during exercise in the heat, enhancing endurance performance.

Methods
12 healthy men ingested 7.5 g/kg body weight of ice slurry (Ice) or the same solution at 37°C (Con) within 30 min. Thereafter, the participants performed cycle exercise for 30 min at 55% of peak oxygen uptake in the heat (35°C), followed by a cycle exercise at 90% of peak oxygen uptake until exhaustion.

Results
Esophageal, rectal, and gastrointestinal temperatures were lower throughout moderate-intensity exercise in the Ice than the Con trial (all P < 0.05). Correspondingly, minute ventilation was lower and cerebral blood flow index was higher in the Ice trial (both P ≤ 0.042, main effects of trial). Subjective severity of diarrhea and stomachache were increased in the Ice vs. Con trial (both P ≤ 0.041, main effects of trial). The duration of high-intensity exercise was not statistically different between the two trials (P = 0.160), though 8 out of the 10 participants exercised for a longer duration in the Ice trial, with a moderate effect size (r = 0.47). Based on z-scores and Grubbs' test, one outlier, who exhibited an extreme increase in ventilation and gastrointestinal complaints following ice slurry ingestion, showed a marked reduction in exercise duration.

Conclusions
Pre-exercise ice slurry ingestion alleviates hyperventilation and cerebral hypoperfusion during sub-maximal exercise in the heat and potentially improve subsequent high-intensity endurance performance, although the adverse effects associated with ice slurry ingestion might hinder the ergogenic effect in some individuals.
Miejsca pozyskiwania aurypigmentu i realgaru w Europie, Afryce i na Bliskim Wschodzie od starożytności do początku XVII w.
Authors: Tarsińska-Petruk Dominika Anna 
Published: February 2025

Aurypigment (As2S3) i realgar (As4S4) – żółty i czerwony siarczek arsenu – należą do najstarszej grupy pigmentów, które były stosowane przez malarzy od starożytności do XIX wieku. Ceniono je w Egipcie, na Bliskim i Dalekim Wschodzie oraz w Europie, gdzie największą popularność zyskały pomiędzy XII a XVII stuleciem. Pigmenty otrzymywano przez ucieranie naturalnych minerałów (aurypigmentu i realgaru) lub w wyniku reakcji chemicznych – prażenia i/lub sublimacji naturalnego aurypigmentu, arsenolitu z siarką i/lub naturalnym aurypigmentem oraz sublimacji siarki z trójtlenkiem arsenu. Aurypigmentu i realgaru używano na równi z cynobrem, malachitem, azurytem. Nakładano je pojedynczo lub łączono z organicznymi i mineralnymi substancjami barwnymi. W przyrodzie obydwa związki występują rzadko. Aurypigment i realgar mineralizują głównie w pobliżu gorących źródeł i fumaroli (czynnych wulkanów). W niniejszym artykule podjęto próbę wstępnego usystematyzowania wiedzy na temat historycznych źródeł pozyskiwania obu minerałów. Omówiono miejsca ich wydobycia wymieniane w traktatach historycznych od starożytności do XVII wieku, przeprowadzono weryfikację – na ile to było możliwe, na podstawie aktualnych badań geologicznych i archeologicznych – aktywności kopalń w ujęciu chronologicznym: od Egiptu (złoża na Pustyni Arabskiej), przez Bliski Wschód (złoża na Wyżynie Irańskiej), Półwysep Azji Mniejszej po Europę (złoża w Allchar w Republice Macedonii Północnej i Tajovie na Słowacji). Porównanie miejsc wydobycia znanych z tekstów historycznych z wybranymi współczesnymi, prezentowanymi na portalach mineralogicznych, może okazać się pomocne w badaniach autentyczności i proweniencji dzieł sztuki z różnych okresów historycznych.
Kazimierskie wozy wojenne w wyprawie z 1590 roku – itinerarium
Authors: Drzewiecki Bartosz , Stańczyk Sebastian 
Published: February 2025

Temat wozów wysyłanych przez polskie miasta na potrzeby wojen w okresie wczesnonowożytnym jest dość dobrze rozpoznany. Historycy zajmowali się dotąd kwestiami ich wyposażenia a także mobilności. Jak dotąd nie zajmowano się jednak budżetami wypraw tego typu jednostek bojowych. Zachowane źródła pozwalają z dużą szczegółowością odtworzyć podróż wozów wojennych z Kazimierza pod zagrożony przez Tatarów Lwów w 1590 r. W artykule dokonano rekonstrukcji trasy 54-dniowej wyprawy oraz jej kosztów dzień po dniu, z uwzględnieniem wynagrodzeń, napraw wozów oraz wyżywienia koni.
Choose Your Battles Wisely: The Consequences of Protesting Government Procurement Contracts
Authors: Canayaz Mehmet I. , Cornaggia Jess , Cornaggia Kimberly 
Published: February 2025

We examine the relationship between a firm’s successful protest of a government agency’s conduct or terms of a procurement contract and the amount of business the firm conducts with the government going forward. We find firms receive fewer and less valuable government contracts, face more contract cancellations, and experience significant reductions in sales growth and employee growth. Despite widespread belief, successful bid protesters do not delay government procurement because of lengthy dispute resolutions. Overall, we provide the first analysis of corporate interactions with the United States government bid protest system. This paper was accepted by Tomasz Piskorski, finance. Supplemental Material: The internet appendix and data files are available at https://doi.org/10.1287/mnsc.2021.02055 .
Preservação dos acervos em museus de Ciências: o caso do Museu Nacional e um olhar sobre a exposição Arqueologia do Resgate
Authors: Souza Peterli dos Santos Rute , Ribeiro Da-Silva Elidiomar 
Published: February 2025

O presente trabalho busca evidenciar, por meio de um questionário, o conhecimento popular sobre as precárias condições em museus no Brasil. Usando a metodologia de análise qualitativa dos dados proposto por Bardin, surgem algumas reflexões desenvolvidas no decorrer do estudo. O trabalho usa o caso do incêndio no Museu Nacional/UFRJ e a exposição Arqueologia do Resgate: Museu Nacional Vive para levantar a questão da situação presente nos museus. Muitos acreditam no museu como local de ensino e educação, refletindo pensamento crítico e atuante sobre a segurança em museus de ciências, e ressaltam que perdemos cultura, arte, ciência e a credibilidade com a trágica ocorrência.
Modernidade líquida e padrão corporal
Authors: Miranda Brum De Sousa Maria Cláudia , Lima Giviziez Marília , Paraíso Alves Marcelo 
Published: February 2025

A presente pesquisa tem como centralidade a articulação entre a mídia, o padrão de beleza imposto pelo mercado e as redes sociais, visto que, o mercado estabelece determinantes que afetam as pessoas em seu cotidiano. Nesta linha de pensamento, o objetivo do trabalho é investigar como as redes sociais investem na produção de corpos que atendam o padrão estético da mídia e indústria cultural. O presente estudo se desenvolveu por intermédio da Revisão Integrativa da Literatura. Foi utilizada como base de dados o Google Acadêmico, tendo como recorte temporal os últimos 5 anos. Como caráter inclusivo foi determinado que apenas os artigos publicados em português iriam compor os dados da pesquisa. Os descritores utilizados foram: corpo e redes sociais; corpo e Instagram. Conclui-se que as redes sociais se configuram como o maior espaço de produção e consumo de corpos idealizados no contexto atual da sociedade, principalmente se considerarmos o Instagram.
Escherichia coli uropatogênica carreadora de blaCTX-M de pacientes ambulatoriais no Rio de Janeiro
Authors: Bauer Canellas Anna Luiza , De Freitas Oliveira Maria Clara , Da Silva Oliveira Alves Gabrielle , Rezende Vieira de Mendonça e Souza Cláudia , Pavoni Gomes Chagas Thiago , Gomes do Rosario Gabriel , M. Rocha Souza Claudio , D’Alincourt Carvalho-Assef Ana Paula , Da Silva Laport Marinella , Piffano Costa Pellegrino Flávia Lúcia 
Published: February 2025

Escherichia coli uropatogênica (UPEC) é o patógeno Gram-negativo mais isolado como causa de infecção no trato urinário (ITU). Cepas de UPEC resistentes aos antimicrobianos têm sido detectadas no mundo todo. O elevado número de prescrições de antibióticos para tratar a ITU, incluindo antimicrobianos da classe dos beta-lactaâmicos, está diretamente associado ao aumento das taxas de resistência de uropatógenos aos antimicrobianos e à disseminação de genes de resistência. Em Escherichia coli, a produção de enzimas beta-lactamases de espectro estendido, conhecidas como ESBLs constitui o principal mecanismo de resistência a antimicrobianos da classe dos beta-lactâmicos, sendo a ESBL do grupo CTX-M a mais prevalente entre amostras de UPEC isoladas no Rio de Janeiro. O objetivo do presente estudo, portanto, foi investigar a presença de genes que codificam ESBLs do tipo CTX-M em cinquenta e três amostras de UPEC recuperadas de pacientes diagnosticados com ITU, atendidos no ambulatório de um hospital público da região metropolitana do Rio de Janeiro, entre maio e junho de 2019. As amostras foram identificadas por MALDI-TOF MS. A presença dos genes blaCTX-M-1,2; blaCTX-M-8 e blaCTX-M-14, foi investigada através da reação em cadeia da polimerase (PCR). Todas as amostras foram identificadas e confirmadas como Escherichia coli. Um total de 12 amostras (23%) foram positivas para os genes blaCTX-M-1,2 mas os genes blaCTX-M-8 e blaCTX-M-14 não foram detectados entre as amostras do estudo. Este achado corrobora com dados da literatura que mostram que CTX-M é a ESBL prevalente em UPEC no Rio de Janeiro e evidencia a crescente dificuldade encontrada pelos clínicos para tratar casos de ITU por UPEC, devido à resistência antimicrobiana.
A supremacia da visualidade e a leitura em contexto digital
Authors: Flexor Carina Ochi 
Published: February 2025

A cultura digital vem provocando mudanças nas experiências leitoras, sobretudo quando se observa a condição ontológica da mídia digital, exigindo olhares atentos acerca da condição da imagem. O artigo – a partir da pesquisa bibliográfica e da observação de objetos empíricos –, considerando a materialidade livresca e os protocolos de leitura próprios dos livros-aplicativos, reflete acerca do lugar da imagem diante da leitura em contexto digital. Tomando como arcabouços teóricos as noções acerca dos protocolos de leitura e a pragmática computacional, o trabalho defende, a partir de uma breve análise dos caminhos da imagem no livro, a reversão hierárquica conquistada por essa matriz de linguagem nos atuais contextos, apontando a imagem como elemento narrativo e janela de acesso à informação em ambientes informáticos.
Coringa, mídia e bionecropolítica
Authors: Zago Luiz Felipe 
Published: February 2025

Toma-se o filme Coringa, de 2019, que narra a transformação de Arthur Fleck em Coringa. O objetivo é mostrar a presença midiática na narrativa, na qual os meios de comunicação atuam de formas decisivas para o personagem fazer-se Coringa. Cenas do filme foram localizadas, descritas, e diálogos foram transcritos, nos quais a materialidade dos meios de comunicação aparece como elemento narrativo. Articulou-se essas cenas aos conceitos de biopolítica e necropolítica. Três formas de relação entre Arthur e a mídia aparecem: desejo de participar da TV para ser reconhecido em sua história como bom filho e bom comediante; reconhecimento de si como “palhaço assassino”, não como criminoso, mas como herói; e uso da mídia para relatar sua indignação e, também, para publicizar a prática de morte.
Arquiteturas afetivas, moradas de imagens: conversa com o artista Alexandre Sequeira
Authors: Ribeiro Vinicios Kabral , De Queiroz Beatriz Morgado , Assunção Diego Paleólogo 
Published: February 2025

A conversa, aqui transcrita, aconteceu virtualmente no dia 14 de setembro de 2020. Sequeira apresentou sua tese “Residência São Jerônimo: entre o acontecimento, a memória e a narrativa”, defendida em 18 de fevereiro de 2020. A casa familiar, entre tantas reminiscências, detalhes e vestígios, onde vive atualmente, transformou-se em uma residência artística, aglutinando, em momentos distintos, 11 artistas. Alexandre Sequeira fez uma exposição inicial, sobre a tese, seguida de uma conversa com os presentes. Transcrevemos as perguntas que surgiram após a apresentação de Sequeira. O encontro foi aberto e estiveram presentes ouvintes não vinculados ao grupo de pesquisa.
The impacts of antipsychotic medications on eating-related outcomes: A mixed methods systematic review
Authors: Alkholy Rasha , Lovell Karina , Bee Penny , Pedley Rebecca , Brooks Helen Louise , Drake Richard J. , Chitsabesan Prathiba , Bhutta Anam , Brown Abigail , Jenkins Rebecca L. , Grundy Andrew 
Published: February 2025

Background
Almost all antipsychotics are associated with weight gain. Given the gravity of this side-effect and its consequences, it is imperative to understand the mechanisms involved. One mechanism that could contribute to this side effect is the impact of antipsychotics on eating-related outcomes.

Objective
We aimed to synthesise the available quantitative research on the effects of first- and second-generation antipsychotics on eating-related outcomes, and qualitative research exploring people’s experiences with these medications in relation to appetite and eating behaviours (PROSPERO protocol CRD42022340211).

Methods
We searched Medline, PsycInfo, and Web of Science from inception to 9 May 2024. Quantitative data were synthesised without meta-analysis using vote counting based on direction of effect. Qualitative data were synthesised using thematic synthesis.

Results
Searches identified 8,746 citations yielding 61 separate studies; 55 quantitative and 6 qualitative, published 1982–2024. Using GRADE, our assessment of the quantitative review findings ranged from low to very low-level certainty. Given the lack of direct evidence from high-quality placebo-controlled trials, it is pertinent to interpret the quantitative findings with caution. Using GRADE-CERQual, our assessment of the qualitative review findings ranged from low to very low-level certainty; these findings suggest that the relationship between antipsychotics and food intake is influenced by an interplay of individual, interpersonal and external factors, the most significant of which is food environment.

Limitations
The internal validity of this review was affected by the serious limitations of the included quantitative studies and the paucity of qualitative evidence.

Strengths
We used GRADE and GRADE-CERQual frameworks to enhance the transparency of our judgement of the certainty of the evidence. Lived experience perspectives were incorporated in different stages of the review to enhance its relevance and practical implications.

Conclusions
There is insufficient evidence from well-conducted studies to determine the effect of antipsychotics on eating-related outcomes.
A systematic review of military-to-civilian transition, The role of gender
Authors: Smith Alexandria , Rafferty Laura , Croak Bethany , Greenberg Neil , Khan Rafiyah , Langston Victoria , Sharp Marie-Louise , Stagg Anne , Fear Nicola , Stevelink Sharon 
Published: February 2025

Background
The military-to-civilian transition can be a challenging period for many service members; however, recent research suggests that female ex-service personnel (veterans) confront additional complexities during reintegration into civilian life. This systematic review aimed to identify and synthesise findings across qualitative studies exploring the impact of gender on this transition process.

Methods
Peer-reviewed literature was drawn from a multi-database search, limited to qualitative studies. The studies included either female veterans or both male and female veterans aged 18 years or older who had previously served in the Armed Forces within the Five Eyes (FVEY) countries (Australia, Canada, New Zealand, the United Kingdom, and the United States). We used a Framework Analysis approach to guide the synthesis of the qualitative data. An assessment of study quality was conducted using the Joanna Briggs Institute (JBI) Qualitative Critical Appraisal Checklist for Qualitative Studies. The study protocol is registered with the Open Science Framework (registration: osf.io/5stuj).

Results
In total, 10,113 articles were screened after the removal of duplicates, 161 underwent full-text review, with 19 meeting the eligibility criteria. The review identified eleven themes split across individual’s experience whilst serving and after transitioning out of the military service. Both male and female veterans discussed a period of acculturation when they joined service and adapted to military norms, culture and identity. Female veterans faced additional challenges at this stage centred on the conflict between feminine norms and the military masculine ideal. Upon leaving service both male and female veterans experienced a loss of military identity and purpose, and dissonance with civilian norms illustrating a military-civilian divide. For female veterans, adjustments and adaptations learned in the military clashed with civilian feminine norms and stereotypically male veteran culture. Female veterans also struggled with the legacies of gender inequality, discrimination, and sexual assault which affected their development of a female veteran identity and affected the provision of services designed to meet their needs as a female. Despite these challenges, female veterans’ expressed pride in their service and accomplishments.

Conclusions
Any effort to improve the military-to-civilian transition should take account of the legacy of gender discrimination, especially within the military service, and the potential mismatch between historical civilian female norms and the more traditionally masculine norms of military life.

Disclosures
This project was supported by a grant from the Forces in Mind Trust (FiMT) 2202.