bluuebunny/crossref_metadata_2025_split huggingface dataset:
Development of Student Worksheets (LKPD) Mathematics Data Processing Material Using Project Based Learning Models in Class V Primary School
Authors: Irianto Sony , Bintaro Tri Yuliansyah , Imam Sochibal 
Published: January 2024

<p>Tujuan penelitian; 1) Mengetahui bentuk pengembangan LKPD materi pengolahan data menggunakan model Project Based Learning, 2) Mengetahui validasi pakar terhadap kelayakan LKPD,3) Mengetahui respon guru terhadap pengembangan LKPD, 4) Mengetahui respon peserta didik terhadap pengembangan LKPD. Metode penelitian mengacu pada model 4-D Thiagarajan, Semmel dan Semmel. Sampel dalam penelitian ini adalah peserta didik kelas V SD Negeri 2 Karang Sentul sebanyak 25 orang. Teknik pengambilan sampel menggunakan teknik purposive sampling dengan tujuan uji terbatas pada 25 peserta didik. Teknik pengumpulan data menggunakan angket validasi ahli, angket respon guru, dan angket respon peserta didik.Teknik analisis data menggunakan teknik deskriptif kuantitatif. Hasil penelitian berupa LKPD yang telah diuji cobakan menggunakan uji coba terbatas pada kelas V SD Negeri 2 Karangsentul. Hasil validasi LKPD mendapatkan kriteria “valid” (3,88), hasil respon guru terhadap penggunaan LKPD mendapatkan kriteria “sangat baik” (4,2), hasil respon peserta didik mendapatkan kriteria “sangat baik” (3,66). Sehingga disimpulkan LKPD Matematika materi pengolahan data melalui kegiatan menghitung kebutuhan sehari-hari dengan menggunakan model project based learning layak digunakan dalam proses pembelajaran matematika.</p>
The Role of School Principals, Independent Learning Curriculum and Teacher Certification on Student Learning Achievement through Student Learning Motivation in Accredited Primary Schools in Cilegon City
Authors: Nurjanah Nurjanah , Suparmoko Muhammad , Mukhlis Ahmad 
Published: January 2024

<p>Kepala sekolah berperan penting pada kurikulum merdeka, sertifikasi guru, dan prestasi belajar siswa. Penelitian ini bertujuan untuk menguji peran kepala sekolah dalam kurikulum merdeka, sertifikasi guru dan prestasi belajar siswa. Metode penelitian yang digunakan adalah metode survey dengan 150 responden. Hasil penelitian antara lain: 1) ada pengaruh Kepala Sekolah terhadap Kurikulum Merdeka. 2) ada pengaruh Kepala Sekolah terhadap sertifikasi guru. 3) ada pengaruh Kepala Sekolah terhadap motivasi belajar siswa. 4) ada pengaruh Kepala sekolah terhadap prestasi belajar siswa. 5) ada pengaruh Kepala sekolah terhadap prestasi belajar siswa. 6) ada Pengaruh Motivasi belajar siswa terhadap prestasi belajar siswa.</p>
Associated factors, concordance, and trends of obesity: body mass index, abdominal waist, and waist- to-height ratio between 2019 and 2022. Analysis of nine national surveys
Authors: Romero Luisa Erika Milagros Vásquez , Vera-Ponce Víctor Juan , Zuzunaga-Montoya Fiorella E. , Torres-Malca Jenny Raquel , Loayza-Castro Joan A. , Paucar Cori Raquel Iturregui , Valladares-Garrido Mario J. , Romero-Figueroa María del Socorro , Silva Mariana , Ramos Willy , Cruz-Vargas Jhony A. La 
Published: January 2024

Abstract
Introduction: Obesity is a global epidemic affecting millions of people worldwide. Its diagnosis and treatment are crucial for the prevention of associated chronic diseases. Objectives: To assess the prevalence of obesity according to different diagnostic criteria, analyze the concordance between various diagnostic methods, and identify associated factors. Methods: Peru's Demographic and Family Health Survey (ENDES) from 2019 to 2022 was utilized. The cut-off points for defining obesity were ≥ 30 for body mass index (BMI), the ATPIII criteria for waist circumference (WC-ATPIII), and 0.56 for the waist-to-height ratio (WHtR). Concordance analyses were performed to compare diagnostic methods and regression analyses were conducted to identify associated factors. Results: The prevalence of obesity according to BMI, WC-ATPIII, and WHtR was 25.65%, 42.04%, and 46.49%, respectively. The concordance between the three criteria was evaluated through the Kappa index. The concordance between obesity by BMI and WC-ATPIII was 0.5141. The concordance between BMI and WHtR was 0.5099. Finally, the concordance between WC-ATPIII and WHtR was 0.7514. Men showed a lower prevalence of obesity compared to women. The obesity trend increased overall during the study period, with marked differences in prevalence according to the obesity measure used. Conclusions: The findings reveal differences in obesity prevalence according to the diagnostic method employed and underscore the need to consider multiple approaches to assess obesity. The results significantly affect public health and provide a foundation for future interventions and policies to combat obesity in Peru.
Predicting the potentially exacerbation of severe viral pneumonia by MuLBSTA score joint CD4+ and CD8+ cell counts: construction and verification of risk warning model
Authors: Chen Xi , Ma Bei , Yang Yu , Zhang Mu , Xu Fang 
Published: January 2024

Abstract
Purpose
This study mainly focuses on the immune function and introduces CD4+, CD8+ and their ratios based on the MuLBSTA score, a previous viral pneumonia mortality risk warning model, to construct an early warning model of severe viral pneumonia risk.
Methods
A retrospective single-center observational study was operated from January 2021 to December 2022 at the People's Hospital of Liangjiang New Area, Chongqing, China. A total of 138 patients who met the criteria for viral pneumonia were selected and their data, including demographic data, comorbidities, laboratory results, CT scans, immunologic and pathogenic tests, treatment regimens, and clinical outcomes, were collected and statistically analyzed.
Results
41 patients (29.7%) developed severe or critical illness. A viral pneumonia severe risk warning model was successfully constructed, including eight parameters: age, bacterial coinfection, CD4+, CD4+/CD8+, multiple lung lobe infiltrations, smoking, hypertension, and hospitalization time. The risk score for severe illness in patients was set at 600 points. The model had good predictive performance (AUROC = 0.94397), better than the original MuLBSTA score (AUROC = 0.8241).
Conclusion
A warning system constructed based on immune function has a good warning effect on the risk of severe conversion in patients with viral pneumonia.
Identifying Mobile Genetic Elements in the Ruminal Microbiome of Nellore Cattle: An Initial Investigation
Authors: Faleiros Camila A. , Nunes Alanne T. , Gonçalves Osiel S. , Alexandre Pâmela A. , Poleti Mirele D. , Oliveira Elisângela C. M. , Junior Flavio Perna , Rodrigues Paulo H. Mazza , Fukumasu Heidge 
Published: January 2024

Abstract
Metagenomics has made it feasible to elucidate the intricacies of the ruminal microbiome and its role in the differentiation of animal production phenotypes of significance. The search for mobile genetic elements (MGEs) has taken on great importance, as they play a critical role in the transfer of genetic material between organisms. Furthermore, these elements serve a dual purpose by controlling populations through lytic bacteriophages, thereby maintaining ecological equilibrium and driving the evolutionary progress of host microorganisms. In this study, we aimed to identify the association between ruminal bacteria and their MGEs in Nellore cattle using physical chromosomal links through the Hi-C method. Shotgun metagenomic sequencing and the proximity ligation method ProxiMeta™ were used to analyze DNA, getting 1,713,111,307 bp, which gave rise to 107 metagenome-assembled genomes from rumen samples of four Nellore cows maintained on pasture. Taxonomic analysis revealed that most of the bacterial genomes belonged to the families Lachnospiraceae, Bacteroidaceae, Ruminococcaceae, Saccharofermentanaceae, and Treponemataceae and mostly encoded pathways for central carbon and other carbohydrate metabolisms. A total of 31 associations between host bacteria and MGE were identified, including 17 links to viruses and 14 links to plasmids. Additionally, we found 12 antibiotic resistance genes. To our knowledge, this is the first study in Brazilian cattle that connect MGEs with their microbial hosts. It identifies MGEs present in the rumen of pasture-raised Nellore cattle, offering insights that could advance biotechnology for food digestion and improve ruminant performance in production systems.
Impact of neoadjuvant chemotherapy on the safety and long-term outcomes of patients undergoing immediate breast reconstruction after mastectomy
Authors: Nogi Hiroko 
Published: January 2024

Abstract
Background.
In breast cancer patients receiving neoadjuvant chemotherapy (NAC), immediate breast reconstruction (IBR) as a breast cancer treatment option remains controversial. We assessed the impact of NAC on surgical and oncological outcomes of patients undergoing IBR.
Methods.
This was a retrospective multicenter study of 4736 breast cancer cases undergoing IBR. The rate of postoperative complications and survival data were compared between IBR patients who received NAC and those who did not receive NAC. Propensity score matching analysis was performed to mitigate selection bias for survival.
Results.
Of the total 4726 cases, 473 (10.0%) received NAC. Out of the cases with NAC, 96 (20.3%) experienced postoperative complications, while 744 cases (17.5%) without NAC had postoperative complications. NAC did not increase the risk of complications after IBR (Odds ratio, 0.96; 95%CI, 0.74–1.25). At the median follow-up time of 76.5 months, 36 patients in the NAC group and 147 patients in the control group developed local recurrences. The 5-year local recurrence-free survival rate was 93.1% in the NAC group and 97.1% in the control group. (P < 0.001). After matching, there was no significant difference between the two groups.
Conclusion.
IBR after NAC is a safe procedure with an acceptable postoperative complication profile and low local recurrence.
Prediction of preoperative the Stone-Free rate in percutaneous nephrolithotomy based on CT clinical-radiomics nomogram: a comparative study with Guy’s stone score and S.T.O.N.E score.
Authors: Zou Xin Chang , Huang Jianbiao , Yuan Rong Man , Jin Meng Ni , Zeng Tao , Chao Hai Chao 
Published: January 2024

Abstract

Purpose: This study aimed to develop a clinical-radiomics nomogram by combining clinical factors and radiomics features.The objective of the nomogram was to predict the stone-free rate(SFR) in percutaneous nephrolithotomy (PCNL). Additionally, the predictive performance of the nomogram was compared with Guy's stone score (GSS) and S.T.O.N.E score.
Patients and methods: A retrospective analysis was conducted on 109 suitable patients with solitary kidney stones who underwent PCNL at the Second Affiliated Hospital of Nanchang University from April 2021 to October 2022.The preoperative clinical data and non-contrast-enhanced CT images of all patients were collected.Radiomic features were extracted from the CT images after preprocessing steps such as wavelet transformation, logization, and resampling. The least absolute shrinkage and selection operator (LASSO) method was used to screen the radiomics features and calculate the radiomics score for each patient using lasso regression coefficient.Multivariate logistic regression analysis was performed to determine the clinical independent predictive factors. These factors were combined with radiomics to construct a clinical-radiomics model, which was visualized using a nomogram.The GSS and S.T.O.N.E score of each patient were calculated and analyzed. The predictive performance of the clinical-radiomics nomogram,Guy’s stone score (GSS),and S.T.O.N.E score was compared and analyzed through identification,calibration,and clinical benefit.
Results: The postoperative statistics revealed a stone-free rate of 65.1%. The results from multivariate logistic regression analysis indicated that the number and diameter of stones were independent risk factors for residual stones after percutaneous nephrolithotomy (PCNL). In the training set, the clinical-radiomics nomogram, GSS and S.T.O.N.E score showed area under the receiver operating curve (ROC) values of 0.925, 0.772 and 0.712, respectively. In the validation set, the AUCs for the clinical-radiomics nomogram, GSS and S.T.O.N.E score were 0.944, 0.786 and 0.714, respectively.The Delong test demonstrated that the clinical-radiomics nomogram exhibited better discrimination ability than GSS and S.T.O.N.E score (p<0.05).The calibration curve and Hosmer-Lemeshow (HL) test confirmed the good calibration ability and fit of the clinical-radiomics nomogram.Furthermore, the decision curve analysis (DCA) revealed that the clinical-radiomics nomogram provided a better net benefit compared to GSS and S.T.O.N.E score.
Conclusion:The clinical-radiomics nomogram constructed based on clinical characteristics and radiomics features can well predict the stone-free rate after PCNL, and its predictive performance is better than the GSS and S.T.O.N.E score.
Sustained xanthine oxidase inhibitor treat to target urate lowering therapy rewires a tight inflammation serum protein interactome
Authors: Sanchez Concepcion , Campeau Anamika , Liu-Bryan Ru , Mikuls Ted , O'Dell James , Gonzalez David , Terkeltaub Robert 
Published: January 2024

Abstract
Background: Effective xanthine oxidoreductase inhibition (XOI) urate-lowering treatment (ULT) to target significantly reduces gout flare burden and synovitis between 1-2 years therapy, without clearing all monosodium urate crystal deposits. Paradoxically, treat to target ULT is associated with increased flare activity for at least 1 year in duration on average, before gout flare burden decreases. Since XOI has anti-inflammatory effects, we tested for biomarkers of sustained, effective ULT that alters gouty inflammation.
Methods: We characterized the proteome of febuxostat-treated murine bone marrow macrophages. Blood samples (baseline and 48 weeks ULT) were analyzed by unbiased proteomics in febuxostat and allopurinol ULT responders from two, independent, racially and ethnically distinct comparative effectiveness trial cohorts (n=19, n=30). STRING-db and multivariate analyses supplemented determinations of significantly altered proteins via Wilcoxon matched pairs signed rank testing.
Results: The proteome of cultured IL-1b-stimulated macrophages revealed febuxostat-induced anti-inflammatory changes, including for classical and alternative pathway complement activation pathways. At 48 weeks ULT, with altered purine metabolism confirmed by serum metabolomics, serum urate dropped >30%, to normal (<6.8 mg/dL) in all the studied patients. Overall, flares declined from baseline. Treated gout patient sera and peripheral blood mononuclear cells (PBMCs) showed significantly altered proteins (p<0.05) in clustering and proteome networks. CRP was not a useful therapy response biomarker. By comparison, significant serum proteome changes included decreased complement C8 heterotrimer C8A and C8G chains essential for C5b-9 membrane attack complex assembly and function; increase in the NLRP3 inflammasome activation promoter vimentin; increased urate crystal phagocytosis inhibitor sCD44; increased gouty inflammation pro-resolving mediator TGFB1; decreased phagocyte-recruiting chemokine PPBP/CXCL7, and increased monocyte/macrophage-expressed keratin-related proteins (KRT9,14,16) further validated by PBMC proteomics. STRING-db analyses of significantly altered serum proteins from both cohorts revealed a tight interactome network including central mediators of gouty inflammation (eg, IL-1B, CXCL8, IL6, C5).
Conclusions: Rewiring of inflammation mediators in a tight serum protein interactome was a biomarker of sustained XOI-based ULT that effectively reduced serum urate and gout flares. Monitoring of the serum and PBMC proteome, including for changes in the complement pathway could help determine onset and targets of anti-inflammatory changes in response to effective, sustained XOI-based ULT.
Trial Registration: ClinicalTrials.gov Identifier: NCT02579096
Seasonal influence of physicochemical and climatic parameters on phytoplankton diversity and abundance pattern in community managed semi- impacted floodplain wetland
Authors: Das Basanta Kumar , Mohanty Trupti Rani , Bhattachaya Shreya , Mondal Kausik , Tiwari Nitish Kumar , Chandra Purna , Karnatak Gunjan , Lianthuamluia Lianthuamluia , Chakraborty Sangeeta , Parida Pranay , Das Archan kanti , Roy Aparna 
Published: January 2024

Abstract

Wetlands provide numerous ecological services and are key habitats for aquatic flora and fauna. In the Beledanga wetland, the current study was conducted for three years, from July 2019 to June 2021, to evaluate the seasonal influence of physico-chemical parameters on phytoplankton diversity and abundance patterns. Overall 48 phytoplankton taxa were observed. Group Bacillariophyceae (27%) contributed the maximum to the total phytoplankton density. The total abundance of phytoplankton was found utmost during monsoon (4.081×103 unit l-1 ) and least during post-monsoon (3.316×103 unit l-1). One-way ANOVA indicated significant seasonal differences (p<0.05) for some genera. The study gave the idea about the most influencing physic-chemical parameters (DO, turbidity, total hardness, Ca2+, and nitrate) on the growth of phytoplankton with the help of different multivariate and univariate analysis (Canonical correspondence analysis, Karl Pearson’s correlation). The study again highlighted that climate parameters (temperature and rainfall) had some effect on the phytoplanktonic groups. Our study conceded that N: P in the studied wetland was less than the Redfield ratio (16:1) in all three seasons,while the Si:P ratio was noticed in the high range (15:1) during pre-monsoon. The value of theShannon diversity index and Margalef’s species richness index were noticed to be > 3, which signified quite rich in phytoplankton diversity and less pollution in the ecosystem. The algal pollution index was predominant during all the seasons, indicating a high organic load which might be due to seasonal jute retting and intensification of agricultural farming.
Simulation research on the thermal phase transition of EDM and the formation mechanism of remelted layer in single pulse spark discharge crater
Authors: Chen Jiaqian , Liu Jianyong , Luo Xueke , Zhang Huijie , Li Dianxin , Kou Pengyuan , Li Ruobing 
Published: January 2024

Abstract
The remelted layer formed by the Electrical Discharge Machine(EDM)impacts surface quality of small hole and significantly reduces the fatigue life of workpieces. Based on Comsol Multiphysics ,this paperusessimulates the formation process of the remelted layer under single-pulse condition. When horizontal set and two-phase flow methods are used to track the phase interface, the model is built under the coupling of flow and heat transfer fields, which simulates the solid-liquid-gas transformation during discharge etching via porous medium and weak expression methods. The simulation results show that the temperature rapidly decreases from the midpoint of the discharge center axis to the surrounding area, and the radius of the plasma region is 95.3 µm. The diameter of the pit is 108.5 µm. The thickness of the remelted layer is 16 µm. The thickness of the remelted layer obtained from experiments under the same conditions is 16.4um. The comparison shows that the difference between the two is small, indicating that the simulation model can accurately predict the thickness of the remelted layer, providing a new approach for evaluating the thickness of the remelted layer in EDM.
Microstate analysis of resting-state electroencephalography in patients with epilepsy with comorbid anxiety and depression
Authors: Yan Rong , Zhang Lijia , Li Fangjing , Liu Wanyu , Tai Zhenzhen , Yang Juan , Tuo Jinmei , Yu Changyin , Zhang Haiqing , Xu zucai 
Published: January 2024

Abstract
Purpose
To explore the characteristics of microstates in patients with epilepsy with comorbid anxiety and depression based on resting-state electroencephalography (EEG).
Methods
We recruited patients with epilepsy who were monitored using video EEG between November 2021 and December 2022 at the affiliated hospital of Zunyi Medical University. Thirty patients with epilepsy with comorbid anxiety and depression (PAD) and 32 patients with epilepsy without anxiety and depression (nPAD) were recruited for this study. Resting-state EEG was conducted for 5 min (in eyes-closed, relaxed, and awake states). EEGLAB and MATLAB were used to process EEG data. Four typical microstate types were observed, including A (auditory), B (visual), C (insular-cingulate), and D (attention). The duration, occurrence, coverage, and transition probabilities of microstates A, B, C, and D of the patients in the two groups were compared, and their correlations with anxiety and depression were analyzed.
Results
Compared to the nPAD group, patients in the PAD group had a shorter disease course and a higher frequency of seizures. Second, the occurrence of microstate C was decreased in patients in the PAD group. Third, the level of anxiety in patients with epilepsy was negatively correlated with the occurrence of microstate C and the transition probabilities from C to A and C to B. However, it was positively correlated with the transition probability from microstate D to A. The level of depression was negatively correlated with the occurrence of microstate C and the transition probabilities from C to A and C to B.
Conclusion
The more frequently patients had seizures (> 2 times per year), the more likely they were to have comorbid anxiety and depression. Moreover, the network connections between the insula and cingulate regions were weakened in patients with epilepsy with comorbid anxiety and depression.
Can the use of azithromycin during labour reduce the incidence of infection among puerperae and newborns? A systematic review and meta-analysis of randomized controlled trials
Authors: Ye Haiyan , Hu Jinlu , Li Bo , Yu Xia , Zheng Xuemei 
Published: January 2024

Abstract
Objective
This systematic review and meta-analysis investigated whether the use of azithromycin during labour or caesarean section reduces the incidence of sepsis and infection among mothers and newborns.
Data sources
We searched the PubMed, Embase and Web of Science databases from inception to June 19, 2023.
Methods
Review Manager 5.4 was used to analyse 6 randomized clinical trials involving 44,448 mothers and 44,820 newborns. Primary outcomes included the incidence of maternal sepsis and all-cause mortality and neonatal sepsis and all-cause mortality; secondary outcomes included maternal (endometritis, mastitis and breast abscess, wound and surgical site infections, chorioamnionitis, and urinary tract infections) and neonatal outcomes (infections of the eyes, ears and skin). A random-effects model was used to test for overall effects and heterogeneity.
Results
The pooled odds ratios (ORs) were as follows: 0.65 for maternal sepsis (95% CI, 0.55–0.77; I2, 0%; P < 0.00001); 0.62 for endometritis (95% CI, 0.52–0.74; I2, 2%; P < .00001); 0.55 for mastitis and breast abscess (95% CI, 0.34–0.89; I2, 40%; P < .02); and 0.43 for maternal wound or surgical site infection (95% CI, 0.24–0.78; P < .005); however, there was great heterogeneity among the studies (I2, 75%). The pooled OR for pyelonephritis and urinary tract infections was 0.3 (95% CI, 0.17–0.52; I2, 0%; P < .0001), and that for neonatal skin infections was 0.48 (95% CI, 0.35–0.65; I2, 0%, P < .00001). There was no significant difference in maternal all-cause mortality or incidence of chorioamnionitis between the two groups. No significant differences were observed in the incidence of neonatal sepsis or suspected sepsis, all-cause mortality, or infections of the eyes or ears.
Conclusion
In this meta-analysis, azithromycin use during labour reduced the incidence of maternal sepsis, endometritis, incisional infections, mastitis and breast abscess, and urinary tract infections but did not reduce the incidence of neonatal-associated infections, except for neonatal skin infections.