bluuebunny/crossref_metadata_2025_split huggingface dataset:
Randomized clinical trial of pulpotomy using a premixed injectable calcium silicate cement on mature permanent teeth with reversible pulpitis
Authors: Cho Sin-Yeon , Park Seonghun , Shin Yooseok , Jung Il-Young 
Published: February 2024

AbstractThe aim of this two-center randomized controlled trial was to assess the outcomes and relative factors associated with pulpotomies performed using a premixed injectable calcium silicate cement, as compared to mineral trioxide aggregate in mature permanent premolar and molar teeth with reversible pulpitis. Included teeth were randomly divided into two groups according to pulpotomy material (ProRoot MTA [PMTA] group, Endocem MTA Premixed [EPM] group). After pulp exposure, the superficial pulp was either removed to a depth of 2 mm (partial pulpotomy) or completely amputated to the level of the root canal orifice (full pulpotomy). A 3-mm layer of either material was randomly placed over the pulp wound, followed by the application of a thin layer of a light-cured glass ionomer composite liner. The restoration procedure was then carried out during the same visit. After one year of treatment, the pulpotomy success rate was 94.4% (67/71), with no significant difference between the PMTA and EPM groups. The success rate was 93.9% in the PMTA group and 97.1% in the EPM group. There were no significant factors related to the procedures. EPM is a viable alternative to PMTA for single-visit pulpotomies of permanent premolars and molars.
Impedance sources (Z sources) with inherent fault protection for resilient and fire-free electricity grids
Authors: Peng Fang Zheng 
Published: February 2024

AbstractModern societies would not survive without electricity and at the same time electrical faults could cause and have caused many catastrophes—mainly deadly fires—to our societies. There are two types of electricity sources: the voltage source such as generators, charged batteries and capacitors, and the current source such as charged inductors, current-regulated rectifiers, and superconducting magnetic energy storage. An “ideal” voltage source—that is often-sought-or-intentionally engineered—generates a constant voltage irrespective of its load current, and an “ideal” current source injects a constant current irrespective of its load voltage. However, two problems exist: (1) voltage or current sources do not represent many emerging natural/renewable energy sources such as wind turbine generators, photovoltaic cells, and fuel cells, whose output voltage and current are strongly dependent on each other, and (2) a short-circuit fault to an artificially-made and controlled “ideal” voltage source or an open-circuit fault to an “ideal” current source can cause catastrophic failures of the source itself and its surrounding circuits due to large (theoretically infinite) short-circuit current or open-circuit voltage. Here we introduce an impedance source concept to represent, characterize, and model those electricity sources whose output voltage and current are strongly dependent on each other. First, we found that many electric sources with no feedback (or active) control of their output voltage and/or current are a natural impedance source with inherent fault protection at short-circuit or open-circuit faults. Second, any electrical source can be artificially controlled to mimic a natural impedance source. Finally, we show how to apply natural impedance sources and nature-mimicking artificially-controlled sources to the electricity grid—the most complex machine ever made by human beings—to realize electricity grids that are naturally stable, self-protected against electrical faults, and resilient to natural and human-made events.
Development of novel polymer haemoglobin based particles as an antioxidant, antibacterial and an oxygen carrier agents
Authors: Majid Muhammad Abdul , Ullah Hafeez , Alshehri Ali Mohammad , Tabassum Rukhsana , Aleem Abdul , Khan Asad ur Rehman , Batool Zahida , Nazir Aalia , Bibi Ismat 
Published: February 2024

AbstractThis innovative work aims to develop highly biocompatible and degradable nanoparticles by encapsulating haemoglobin (Hb) within poly-ε-caprolactone for novel biomedical applications. We used a modified double emulsion solvent evaporation method to fabricate the particles. A Scanning electron microscope (SEM) characterized them for surface morphology. Fourier Transform Infrared Spectroscopy (FTIR) and Ultraviolet–visible spectroscopies (UV–visible) elucidated preserved chemical and biological structure of encapsulated haemoglobin. The airproof equilibrium apparatus obtained the oxygen-carrying capacity and P50 values. The DPPH assay assessed free radical scavenging potential. The antibacterial properties were observed using four different bacterial strains by disk diffusion method. The MTT assay investigates the cytotoxic effects on mouse fibroblast cultured cell lines (L-929). The MTT assay showed that nanoparticles have no toxicity over large concentrations. The well-preserved structure of Hb within particles, no toxicity, high oxygen affinity, P50 value, and IC50 values open the area of new research, which may be used as artificial oxygen carriers, antioxidant, and antibacterial agents, potential therapeutic agents as well as drug carrier particles to treat the cancerous cells. The novelty of this work is the antioxidant and antibacterial properties of developed nanoparticles are not been reported yet. Results showed that the prepared particles have strong antioxidant and antibacterial potential.
Application of a novel metaheuristic algorithm inspired by stadium spectators in global optimization problems
Authors: Nemati Mehrdad , Zandi Yousef , Agdas Alireza Sadighi 
Published: February 2024

AbstractThis paper presents a novel metaheuristic algorithm inspired by the actions of stadium spectators affecting behavior of players during a match which will be called stadium spectators optimizer (SSO) algorithm. The mathematical model of the SSO algorithm is presented and the performance and efficiency of the presented method is tested on some of the well-known mathematical test functions and also CEC-BC-2017 functions. The SSO algorithm is a parameter-free optimization method since it doesn't require any additional parameter setup at any point throughout the optimization process. It seems urgently necessary to design a novel metaheuristic algorithm that is parameter-free and capable of solving any optimization problem without taking into account extra parameters, as the majority of metaheuristic algorithms rely on the configuration of extra parameters to solve different problems efficiently. A positive point for the SSO algorithm can be seen in the results of the suggested technique, which indicate a partial improvement in performance. The results are compared with those of golf optimization algorithm (GOA), Tiki taka optimization algorithm (TTA), Harris Hawks optimization algorithm (HHO), the arithmetic optimization algorithm (AOA), CMA-ES and EBOwithCMAR algorithms. The statistical tests are carried out for the obtained results and the tests reveal the capability of the presented method in solving different optimization problems with different dimensions. SSO algorithm performs comparably and robustly with the state-of-the-art optimization techniques in 14 of the mathematical test functions. For CEC-BC-2017 functions with ten dimensions, EBOwithCMAR performs better than the proposed method. However, for most functions of CEC-BC-2017 with ten dimensions, the SSO algorithm ranks second after EBOwithCMAR, which is an advantage of the SSO since the proposed method performs better than the well-known CMA-ES optimization algorithm. The overall performance of the SSO algorithm in CEC-BC-2017 functions with 10 dimensions was acceptable, in dimension of 30, 50 and 100, the performance of the proposed method in some functions decreased.
Updating of pelvimetry standards in modern obstetrics
Authors: Tresch Caroline , Lallemant Marine , Nallet Camille , Offringa Yvonne , Ramanah Rajeev , Guerby Paul , Mottet Nicolas 
Published: February 2024

AbstractClinical value of pelvimetry in modern obstetrics practices has never been established and normal values are set since the middle of the twentieth century. The aim of this study was to describe current dimensions of pelvis in a female French Caucasian population. A retrospective, bi-centric observational study was conducted from August 2013 to August 2019 in two French departments of Obstetrics. We included all Caucasian women who had a computed tomography pelvimetry during pregnancy. The primary outcome was the values of the obstetric transverse diameter, obstetric conjugate diameter and bispinous diameter. Five hundred and fifty-one CT pelvimetries were analyzed. The median Obstetric Transverse Diameter (OTD) was 12.41 cm and the 3rd percentile was 11 cm. The median Obstetric Conjugate Diameter (OCD) was 12.2 cm and the 3rd percentile was 10.5 cm. The median Bispinous Diameter (BSD) in our data collection was 10.9 cm and the 3rd percentile was 9.3 cm. A significant correlation coefficient between women’s height and OTD, OCD and BSD was found. In our study, the OCD and the BSD have not evolved since the middle of the twentieth century. The obstetric transverse diameter was smaller than the standard currently used.
Recognition of emotions in German laughter across cultures
Authors: Szameitat Diana P. , Szameitat André J. 
Published: February 2024

AbstractLaughter conveys a wide range of information relevant for social interaction. In previous research we have shown that laughter can convey information about the sender’s emotional state, however other research did not find such an effect. This paper aims to replicate our previous study using participant samples of diverse cultural backgrounds. 161 participants from Poland, the UK, India, Hong Kong, and other countries classified 121 spontaneously emitted German laughter sounds according to the laughter type, i.e., joyful, schadenfreude, and tickling laughter. Results showed that all participant groups classified the laughter sounds above chance level, and that there is a slight ingroup advantage for Western listeners. This suggests that classification of laughter according to the sender’s emotional state is possible across different cultures, and that there might be a small advantage for classifying laughter of close cultural proximity.
Analytical performance validation of aPROMISE platform for prostate tumor burden, index and dominant tumor assessment with 18F-DCFPyL PET/CT. A pilot study
Authors: García Vicente Ana María , Lucas Lucas Cristina , Pérez-Beteta Julián , Borrelli Pablo , García Zoghby Laura , Amo-Salas Mariano , Soriano Castrejón Ángel María 
Published: February 2024

AbstractTo validate the performance of automated Prostate Cancer Molecular Imaging Standardized Evaluation (aPROMISE) in quantifying total prostate disease burden with 18F-DCFPyL PET/CT and to evaluate the interobserver and histopathologic concordance in the establishment of dominant and index tumor. Patients with a recent diagnosis of intermediate/high-risk prostate cancer underwent 18F-DCFPyL-PET/CT for staging purpose. In positive-18F-DCFPyL-PET/CT scans, automated prostate tumor segmentation was performed using aPROMISE software and compared to an in-house semiautomatic-manual guided segmentation procedure. SUV and volume related variables were obtained with two softwares. A blinded evaluation of dominant tumor (DT) and index tumor (IT) location was assessed by both groups of observers. In histopathological analysis, Gleason, International Society of Urological Pathology (ISUP) group, DT and IT location were obtained. We compared all the obtained variables by both software packages using intraclass correlation coefficient (ICC) and Cohen’s kappa coefficient (k) for the concordance analysis. Fifty-four patients with a positive 18F-DCFPyL PET/CT were evaluated. The ICC for the SUVmax, SUVpeak, SUVmean, tumor volume (TV) and total lesion activity (TLA) was: 1, 0.833, 0.615, 0.494 and 0.950, respectively (p < 0.001 in all cases). For DT and IT detection, a high agreement was observed between both softwares (k = 0.733; p < 0.001 and k = 0.812; p < 0.001, respectively) although the concordances with histopathology were moderate (p < 0001). The analytical validation of aPROMISE showed a good performance for the SUVmax, TLA, DT and IT definition in comparison to our in-house method, although the concordance was moderate with histopathology for DT and IT.
Rice husk silica blended fillers for engine mount application
Authors: Ubi Paschal A. , Ademoh Nuhu A. , Anosike-Francis Esther N. , Salawu Abdulrahman A. , Adeleke Adekunle A. , Okoro Uzoma G. , Abdullahi Aliyu A. , Ngolemasango Frederick 
Published: February 2024

AbstractThe functional properties of engine mounts largely depend on the rubber compound formulation. This study proposes the use of rice husk–derived silica (RHS) blended with carbon black (N772) as an effective and environmentally friendly substitute for fillers used in rubber engine mounts (REMs). CV-60 natural rubber was filled with the blended fillers at various ratios, and their compatibility for use as rubber engine mounts (REMs) was assessed. Grey Relational Analysis was utilised to determine the optimal blend loading levels for use in rubber engine mounts, resulting in 40 phr of N772 and 20 phr of RHS cured at 130 °C and 2.5 MPa for 20 min. The developed REMs and conventional REMs had low vibration data variation during the performance assessment. Their resonance transmissibility was 5.03 and 3.74, corresponding to natural frequencies of 24.27 Hz and 26.94 Hz, respectively. The RHS/N772 REMs had excellent damping characteristics and lower transmissibility in the isolation zone of the vibration isolation curve, which is outside of the resonant frequency region. The efficiency curves showed that the blended fillers are a better and more effective material for REMs at all frequencies, balancing static deflection and vibration isolation.
Single-cell low-pass whole genome sequencing accurately detects circulating tumor cells for liquid biopsy-based multi-cancer diagnosis
Authors: Shen Xiaohan , Dai Jiao , Guo Lingchuan , Liu Zhigang , Yang Liu , Gu Dongmei , Xie Yinghong , Wang Zhuo , Li Ziming , Xu Haimiao , Shi Qihui 
Published: February 2024

AbstractAccurate detection of circulating tumor cells (CTCs) in blood and non-blood body fluids enables generation of deterministic cancer diagnosis and represent a less invasive and safer liquid biopsy approach. Although genomic alternations have been widely used in circulating tumor DNA (ctDNA) analysis, studies on cell-based genomic alternations profiling for CTC detection are rare due to major technical limitations in single-cell whole genome sequencing (WGS) including low throughput, low accuracy and high cost. We report a single-cell low-pass WGS-based protocol (scMet-Seq) for sensitive and accurate CTC detection by combining a metabolic function-associated marker Hexokinase 2 (HK2) and a Tn5 transposome-based WGS method with improved cell fixation strategy. To explore the clinical use, scMet-Seq has been investigated with blood and non-blood body fluids in diagnosing metastatic diseases, including ascites-based diagnosis of malignant ascites (MA) and blood-based diagnosis of metastatic small-cell lung cancer (SCLC). ScMet-Seq shows high diagnostic sensitivity (MA: 79% in >10 cancer types; metastatic SCLC: 90%) and ~100% of diagnostic specificity and positive predictive value, superior to clinical cytology that exhibits diagnostic sensitivity of 52% in MA diagnosis and could not generate blood-based diagnosis. ScMet-Seq represents a liquid biopsy approach for deterministic cancer diagnosis in different types of cancers and body fluids.
Umgang mit eigenen Krisenerfahrungen in der Selbsterfahrung: Eine
standardisierte Befragung in psychiatrischen Einrichtungen in Berlin und
Brandenburg
Authors: Brieger Anna Rina , von Peter Sebastian , Ponew Angel , Lust Christian , Speerforck Sven , Stützle Stefan 
Published: February 2024

Zusammenfassung
Ziel der Studie Die vorliegende Arbeit untersucht erstens, ob die
Fachkräfte ihre Krisen- und Behandlungserfahrungen in ihrer
Selbsterfahrung thematisierten. Zweitens wird beleuchtet, ob und inwieweit sie
konzeptuell zwischen den Formaten Selbsterfahrung und Psychotherapie
unterscheiden.
Methodik Im Rahmen einer Onlineumfrage wurden 108 Fachkräfte mit
psychotherapeutischer Qualifikation zu ihrer Selbsterfahrung befragt.
Zusammenhänge zwischen der Bearbeitung eigener Krisen in der
Selbsterfahrung, der Krisenhäufigkeit und dem erlebten Nutzen der
Selbsterfahrung wurden mittels Korrelationen analysiert. Zur Analyse
konzeptueller Unterschiede zwischen Selbsterfahrung und Psychotherapie wurden
den Teilnehmenden neun inhaltliche Aspekte vorgelegt, die sie bezüglich
ihrer Bedeutsamkeit für beide Formate einschätzten. Die
Mittelwerte der Einschätzungen wurden zwischen verschiedenen Subgruppen
mittels t-Tests verglichen.
Ergebnisse Die Teilnehmenden gaben überwiegend an, eigene
Krisenerfahrungen in der Selbsterfahrung bearbeitet und von der Selbsterfahrung
profitiert zu haben. Zwischen beiden Größen zeigte sich ein
signifikanter Zusammenhang. Hinsichtlich der konzeptionellen Abgrenzung der
Formate ergab sich ein differenziertes Bild: Die Teilnehmenden ordneten
persönlich-biographische Kategorien eher der Psychotherapie zu,
berufliche Kategorien eher der Selbsterfahrung.
Diskussion Angesichts der unter psychosozialen Fachkräften
verbreiteten Stigmatisierung von Personen mit psychischen Gesundheitsproblemen
war es überraschend, dass viele Teilnehmende eigene Krisenerfahrungen in
der Selbsterfahrung thematisierten und dabei positive Erfahrungen machen
konnten. Ebenso war die stärkere Zuordnung
persönlich-biographischer Inhaltsaspekte zur Psychotherapie im Vergleich
zur Selbsterfahrung überraschend, vor allem in Bezug auf die Bedeutung
des psychotherapeutischen Wirkfaktors Beziehung.
Schlussfolgerung Selbsterfahrung sollte ein stigmafreier Raum sein, in dem
angehende Therapeut*innen ohne Angst ihre persönlichen
Belastungen thematisieren und dadurch als Personen wachsen können.
Manfred Pflanz (1923–1980) – zentraler Akteur bei der
Institutionalisierung von Sozialmedizin und Medizinsoziologie
Authors: Delventhal Christina , Roelcke Volker 
Published: February 2024

ZusammenfassungDer Internist, Sozialmediziner, Medizinsoziologe und Epidemiologe Manfred Pflanz
(1923–1980) war ein zentraler Akteur in der institutionellen
Formierungsphase von Sozialmedizin und Medizinsoziologie in Westdeutschland in
den 1960er und 70er Jahren. Der Beitrag beschreibt seine Biografie und
Arbeitsschwerpunkte, seine programmatischen Vorstellungen zu Sozialmedizin und
Medizinsoziologie sowie seine Aktivitäten im Kontext von Politikberatung
im Bereich des Gesundheitswesens. Er liefert damit auch einen Einblick in die
Entstehungsbedingungen, die zeitgenössischen Arbeitsprogramme und die
internationale Einbettung dieser sich teilweise überschneidenden
Arbeitsfelder.
Evidenz für die minimalinvasive Ösophagusresektion
Authors: Nienhüser Henrik , Schmidt Thomas 
Published: February 2024

ZusammenfassungIn den letzten zwei Jahrzehnten hat die minimalinvasive Chirurgie in allen Bereichen einen extremen Zuwachs an Bedeutung erlangt. Hierbei sind insbesondere in der onkologischen Chirurgie Operationsverfahren etabliert worden, ohne dass hierfür die notwendige Evidenz generiert wurde, die eine gleichwertige Qualität zu den offenen Verfahren nachgewiesen hat. Hierfür wurde erst in den vergangenen Jahren durch randomisiert-kontrollierte Studien und nachfolgende Metaanalysen die entsprechende Evidenz geniert. In diesem Artikel wird die Evidenz für die minimalinvasive Ösophagusresektion beschrieben und ein Überblick über die aktuelle Literatur in den jeweiligen Verfahren zusammengefasst.
Incidence and factors associated with stent dysfunction and pancreatitis after gastroduodenal stenting for malignant gastric outlet obstruction
Authors: Yamashige Daiki , Hijioka Susumu , Nagashio Yoshikuni , Maruki Yuta , Fukuda Soma , Yagi Shin , Okamoto Kohei , Hara Hidenobu , Hagiwara Yuya , Agarie Daiki , Takasaki Tetsuro , Chatto Mark , Ohba Akihiro , Kondo Shunsuke , Morizane Chigusa , Ueno Hideki , Sone Miyuki , Saito Yutaka , Okusaka Takuji 
Published: February 2024

Abstract
Background and study aims Endoscopic gastroduodenal stent (GDS) deployment is currently a standard treatment for malignant gastric outlet obstruction (mGOO) in patients with limited life expectancy; however, stent dysfunction (SD) and complicated pancreatitis often occur after GDS deployment. We investigated incidence and contributing factors of SD and complicated pancreatitis.
Patients and methods We retrospectively reviewed 203 patients who underwent initial GDS deployment for palliation of mGOO symptoms between October 2017 and July 2022, including 109 who underwent GDS deployment across the duodenal papilla (sub-cohort).
Results SDs, including tumor ingrowth (n = 26), kinking (n = 14), and migration (n = 13), occurred in 68 patients (33.5%). Cumulative SD incidence was 41.1% (95% confidence interval, 32.6–49.4%). SD incidence increased to 0.4%, 0.16%, and 0.06% per day at < 8, 8–16, and>16 weeks, respectively. On multivariate analysis, Niti-S pyloric/duodenal stent deployment (sub-distribution hazard ratio [sHR] 0.26, P = 0.01) and survival length ≥ 90 days (sHR 2.5, P = 0.01) were respectively identified as favorable and risk factors significantly associated with SD. Pancreatitis developed in 14 patients (12.8%) in the sub-cohort, which had significantly higher parenchymal diameter (P < 0.01) and lower main pancreatic duct (MPD) caliber (P < 0.01) than the non-pancreatitis cohort. On multivariate analysis, MPD caliber < 3 mm independently predicted pancreatitis (odds ratio 6.8, P = 0.03).
Conclusions Deployment of the Niti-S pyloric/duodenal stent, with conformability even for angulated strictures, significantly reduced the incidence of SD. Stent selection, life expectancy, and MPD caliber should be taken into consideration during decision-making for GDS deployment for mGOO.
The Prevalence of Dysphagia in Children with Laryngomalacia Pre and Postsupraglottoplasty: A Systematic Review with Meta-Analysis
Authors: Rossoni Eduarda Pinto , Miranda Vanessa Souza Gigoski de , Barbosa Lisiane De Rosa 
Published: February 2024

Abstract
Introduction Laryngomalacia is the most common congenital laryngeal alteration, with spontaneous resolution in most cases. However, in the face of more severe presentations of the disease, it is necessary to perform supraglottoplasty surgery. Studies have been dedicated to researching changes in swallowing in children with laryngomalacia before and after surgical intervention.
Objectives To identify the prevalence of oropharyngeal dysphagia in children with pre and postsupraglottoplasty laryngomalacia.
Data Synthesis A search strategy was developed with terms and entreterms to designate a population pediatric with laryngomalacia, exposure supraglottoplasty, and outcome frequency of dysphagia, adapted to the requirements of the main databases in the health area. The analysis of the records found was performed by two independent examiners and, in the end, 6 articles were included in the study. The articles found enabled a sample of 330 children with laryngomalacia, 311 of whom underwent supraglottoplasty. Among the included studies, 5 were grouped and meta-analyzed. After supraglottoplasty surgery, a 59% reduction in the prevalence of oropharyngeal dysphagia was identified, with high heterogeneity I2 = 93%.
Conclusion Despite the heterogeneity of the sample, the supraglottoplasty procedure significantly reduces the prevalence of dysphagia in children with laryngomalacia.