bluuebunny/crossref_metadata_2025_split huggingface dataset:
Brain-wide presynaptic networks of functionally distinct cortical neurons
Authors: Inácio Ana R. , Lam Ka Chun , Zhao Yuan , Pereira Francisco , Gerfen Charles R. , Lee Soohyun 
Published: February 2025

Abstract
Revealing the connectivity of functionally identified individual neurons is necessary to understand how activity patterns emerge and support behaviour. Yet the brain-wide presynaptic wiring rules that lay the foundation for the functional selectivity of individual neurons remain largely unexplored. Cortical neurons, even in primary sensory cortex, are heterogeneous in their selectivity, not only to sensory stimuli but also to multiple aspects of behaviour. Here, to investigate presynaptic connectivity rules underlying the selectivity of pyramidal neurons to behavioural state1–10 in primary somatosensory cortex (S1), we used two-photon calcium imaging, neuropharmacology, single-cell-based monosynaptic input tracing and optogenetics. We show that behavioural state-dependent activity patterns are stable over time. These are minimally affected by direct neuromodulatory inputs and are driven primarily by glutamatergic inputs. Analysis of brain-wide presynaptic networks of individual neurons with distinct behavioural state-dependent activity profiles revealed that although behavioural state-related and behavioural state-unrelated neurons shared a similar pattern of local inputs within S1, their long-range glutamatergic inputs differed. Individual cortical neurons, irrespective of their functional properties, received converging inputs from the main S1-projecting areas. Yet neurons that tracked behavioural state received a smaller proportion of motor cortical inputs and a larger proportion of thalamic inputs. Optogenetic suppression of thalamic inputs reduced behavioural state-dependent activity in S1, but this activity was not externally driven. Our results reveal distinct long-range glutamatergic inputs as a substrate for preconfigured network dynamics associated with behavioural state.
The development of media truth discernment and fake news detection is related to the development of reasoning during adolescence
Authors: Lemaire Marine , Ye Steeven , Le Stanc Lorna , Borst Grégoire , Cassotti Mathieu 
Published: February 2025

Abstract
The spread of online fake news is emerging as a major threat to human society and democracy. Previous studies have investigated media truth discernment among adults but not among adolescents. Adolescents might face a greater risk of believing fake news, particularly fake news that is shared via social media, because of their vulnerabilities in terms of reasoning. In the present study, we investigated (1) the development of media truth discernment and the illusory truth effect from adolescence to adulthood and (2) whether the development of media truth discernment and the illusory truth effect are related to the development of reasoning ability. To accomplish this task, we recruited 432 adolescents aged 11 to 14 years as well as 132 adults. Participants were asked to rate the perceived accuracy of both real and fake news headlines. Participants were exposed to half of the news items before entering the rating phase. Finally, participants completed the Cognitive Reflection Test (CRT). Media truth discernment (i.e., the difference between participants’ ratings of fake and real news) developed linearly with increasing age, and participants rated familiarized headlines as more accurate than novel headlines at all ages (i.e., the illusory truth effect). Finally, media truth development (but not the illusory truth effect) was related to the development of reasoning abilities with increasing age. Our findings highlight the urgent need to improve logical thinking among adolescents to help them detect fake news online.
Comparison of cryogenic and non-cryogenic droplet impact dynamics at low Weber numbers
Authors: Tretola Giovanni , Vogiatzaki Konstantina 
Published: February 2025

Abstract
Cryogenic fluids are crucial in applications such as rockets, cryosurgery and energy storage, where they can come in contact with surfaces. Thus, their impact dynamics are of interest. Experiments under cryogenic conditions are very expensive and not always accurate, mainly due to limitations of equipment operating in very low temperatures. Although simulation tools can provide useful insights, currently very few commercial and open-source software tailored for ultra low temperature conditions exist. In this work we present a novel numerical framework used to provide insight into the impact dynamics of cryogenic droplets with solid surfaces. Our aim is to explore whatever conclusions for droplet spreading dynamics from the current literature for droplets at non-cryogenic conditions can be applied to cryogenic droplets as well. We explore different impacting conditions, varying the initial impact velocity, of cryogenic and non-cryogenic cases, while maintaining the same Weber, Ohnesorge and Reynolds numbers between cryogenic and non-cryogenic cases. The impact on a solid surface is investigated first for a water droplet and then for a liquid oxygen droplet moving into gaseous nitrogen. For the latter, the ambient temperature and pressure are below the oxygen critical point, limiting the investigation at a sub-critical regime. The algebraic volume of fluid method with adaptive mesh refinement is employed. Numerical treatments to improve the interface description are also implemented. The simulations have been performed in OpenFOAM with a newly developed code. The results obtained are analysed both qualitatively and quantitatively, comparing the droplet morphology evolution for the two fluids. Differences are observed mainly in the receding stage, once the droplet has reached the maximum spreading, with the receding stage of the cryogenic case characterised by a faster dynamic.
Multi-material 3D printed composites inspired by nacre: a hard/soft mechanical interplay
Authors: Curto Marco , Dowsett Jack , Kao Alexander P. , Tozzi Gianluca , Barber Asa H. 
Published: February 2025

Abstract
Structural materials are used extensively in nature where mechanical function is required. These structures are composites consisting of soft and, in some cases, hard phases precisely distributed over different length scales. Bio-inspiration aims at producing materials with structure, design and/or mechanical properties adopted from biological tissues. To reproduce complex structures found in nature, additive manufacturing (AM) using three-dimensional printing (3DP) is an attractive method to assemble complex topologies with resolutions approaching the micro and nano-composition. Specifically, high-resolution MultiJetPrinting (MJP) 3D printing allows the simultaneous deposition of soft and hard photo curable plastic resins. Nacre is a prevalent example of a complex biological composite material organization that can test the ability of MJP to manufacture a bio-inspired engineering structure, where the organization of materials in nacre is optimized to avoid catastrophic failure. The ability to generate complex 3D organizations required to mimic the structure of nacre by controlled organization of soft and hard materials is achieved here using a generative design approach. Such a generative design is further enhanced by incorporating two differing MJP directions that provide relatively strong and weak interfaces between the soft and hard material phases. Consideration of classical stress transfer theory between at a hard material reinforcement interface was shown to correlate with experimental observations of mechanical performance and failure in 3D printed nacre inspired composites. Thus, the ability to distribute materials with a range of mechanical properties and incorporate further interfacial design is demonstrated. The approach presented is flexible and allows complex bio-inspired composites to be 3D printed that incorporate different interfacial quality through changing printing direction.
Psychometric evaluation of the Chinese version of the Patient Self-Advocacy Scale using classical test theory and item response theory
Authors: Cui Jialu , Wang Jing , Yue Ailin , Cao Jiayan , Zhang Zhijie , Shi Baoxin 
Published: February 2025

Abstract
Background: Patient self-advocacy plays a crucial role in improving cancer patients’ quality of life, but there is no validated instrument to assess this concept among Chinese head and neck cancer patients. This study aimed to cross-culturally translate the Patient Self-Advocacy Scale (PSAS) and evaluate its psychometric properties using classical test theory and item response theory. Methods: The PSAS underwent cross-cultural adaptation based on Brislin’s translation model and a cross-sectional survey of 302 head and neck cancer patients at a tertiary hospital in Tianjin was conducted from November 2023 to August 2024. Classical test theory was used for item analysis and validation of reliability (internal consistency, test-retest reliability) and validity (content validity, construct validity). Item response theory was applied to evaluate model fit, reliability, item difficulty, and measurement invariance. Results: Classical test theory analysis demonstrated good item discrimination with item-total correlations ranging from 0.776 to 0.942 and critical ratios from 13.269 to 33.170 (p < 0.05), as well as good internal consistency (Cronbach’s α = 0.942 for the total scale) and test-retest reliability (ICC = 0.840 for the total scale, p < 0.001). I-CVI values ranged from 0.80 to 1.00, with an S-CVI of 0.95. The three-factor model demonstrated good fit (χ2/df = 2.595, RMSEA = 0.090, SRMR = 0.072, CFI = 0.966, IFI = 0.966, TLI = 0.956). Rasch analysis indicated a good model fit and reliability (person/item separation index > 1.5, person/item reliability coefficient > 0.9). The Wright map showed good matching between item difficulty and person ability. Differential item functioning (DIF) analysis revealed no significant differences across gender. Conclusion: The Chinese version of PSAS demonstrates satisfactory psychometric properties among head and neck cancer patients and provides healthcare providers with a tool to assess patients’ self-advocacy, potentially facilitating patient-centered care and self-management in clinical practice and improving patients’ health and quality of life outcomes.
Factors associated with reduction in quality of life after SARS-CoV-2 infection
Authors: Neumann Christian , Hartung Tim J. , Boje Klara , Bahmer Thomas , Keil Julian , Lieb Wolfgang , Franzpoetter Katrin , Welzel Julius , Chaplinskaya-Sobol Irina , Endres Matthias , Geritz Johanna , Haeusler Karl Georg , Heuschmann Peter , Hinz Andreas , Hopff Sina , Horn Anna , Nuernberger Carolin , Schmidbauer Lena , Krawczak Michael , Ruß Anne-Kathrin , Krist Lilian , Keil Thomas , Kudelka Jennifer , Maetzler Corina , Mehnert-Theuerkauf Anja , Montellano Felipe A. , Morbach Caroline , Schmidt Sein , Heyckendorf Jan , Steigerwald Flo , Stoerk Stefan , Lemhoefer Christina , Schreiber Stefan , Finke Carsten , Maetzler Walter 
Published: February 2025

Abstract
Long-term changes in health-related quality of life (HrQoL) after SARS-CoV-2 infection are common, but their causes and consequences are poorly understood. This prospective, population-based study examined associations between HrQoL and 49 demographic and clinical variables. HrQoL was assessed using the European Quality-of-Life-5-Dimensions-5-Level-Version in 3,475 participants (56% female; aged 18–88 years) approximately 9 months (baseline) and 26 months (follow-up) after their initial infection. Results were compared with the demographic and clinical variables using recursive feature elimination and random forest regression analyses. A statistically significant improvement in HrQoL was observed during the observation period. At baseline, 39% of the variance in HrQoL was explained by fatigue, muscle pain, number of remaining symptoms (RS), perceived stress, and age. At follow-up, fatigue, RS, perceived stress, muscle and joint pain, and age explained 54% of the variance in HrQoL. Changes in HrQoL were associated with changes in fatigue, RS, and perceived stress, meaning that if these decreased from baseline to follow-up, then HrQoL was improved. However, it was not possible to predict whether an individual’s HrQoL would improve or worsen 1 year later based on baseline variable scores. The aforementioned symptoms are specifically associated with impairment in the population’s usual activities.
Candida albicans aspartyl protease (Sap6) inhibits neutrophil function via a “Trojan horse” mechanism
Authors: Zawrotniak Marcin , Satala Dorota , Juszczak Magdalena , Bras Grażyna , Rapala-Kozik Maria 
Published: February 2025

Abstract

Candida albicans, a prevalent fungal pathogen, employs aspartyl proteases such as Sap6 to evade immune defenses, challenging our understanding of host‒pathogen interactions. This research examined the impact of Sap6 on neutrophil responses, which are crucial for innate immunity. Employing flow cytometry and fluorescence microscopy, we explored how Sap6 affects neutrophil functions, particularly by focusing on reactive oxygen species (ROS) production, neutrophil extracellular traps release (NETosis), and apoptosis. Our findings revealed Sap6’s unique ability to bind and internalize in neutrophils, significantly attenuating ROS production through proteolytic damage to NADPH oxidase, resulting in blocking the ROS-dependent NETosis pathway. This disruption in neutrophil functions by Sap6 suggested the presence of a ‘Trojan horse’ mechanism by C. albicans. This mechanism reveals a sophisticated immune evasion strategy, shedding light on fungal pathogenicity and host immune interactions. Understanding fungal proteases in immune modulation could inspire new therapeutic approaches for fungal infections.
Audio-Video-Dokumentation in der Psychotherapie: Sichern, Schützen, Archivieren
Authors: Grühn Manfred 
Published: February 2025

ZusammenfassungIn der modernen Psychotherapie gewinnen Audio- und Videoaufzeichnungen zunehmend an Bedeutung. Sie ermöglichen tiefere Einblicke, unterstützen Supervisionen und fördern die Qualitätssicherung. Doch mit diesen Vorteilen geht auch eine große Verantwortung einher: der Schutz sensibler Daten. Dieser Artikel beleuchtet die Herausforderungen und gibt praxisnahe Beispiele, wie sich Datenschutz und Sicherheit in der Praxis umsetzen lassen.
Die Narrative Expositionstherapie – Praktische Anwendung
Authors: Wilker Sarah , Neuner Frank 
Published: February 2025

ZusammenfassungDie Narrative Expositionstherapie (NET) wurde als ein maximal pragmatischer Ansatz der Traumatherapie entwickelt, um Menschen in ressourcenarmen Konfliktgebieten einen Zugang zu evidenzbasierter Behandlung zu ermöglichen. Das zentrale Merkmal der NET ist das gemeinsame Erzählen der Lebensgeschichte in der Therapie.
Schmerz und Psychotherapie – eine kultursensitive Perspektive
Authors: Tamcan Özgür 
Published: February 2025

ZusammenfassungSomatoforme Störungen sind bei Menschen mit Migrationshintergrund gehäuft vorzufinden. Das ist eine doppelte Herausforderung: Eine chronische Schmerzstörung braucht einerseits ein breites multiprofessionelles Behandlungsprogramm, andererseits könnte die Symptomatik bei Menschen mit einem anderen kulturellen Hintergrund verschiedene persönliche und kulturelle Bedeutung innehaben, was wiederum sowohl die Diagnose als auch die Therapieplanung erschweren kann.
Psycho-emotionale Phasen der Migration
Authors: Kizilhan Jan Ilhan , Klett Claudia 
Published: February 2025

ZusammenfassungSo unterschiedlich die individuellen Migrationserfahrungen und deren Erleben sind, lassen sich dennoch gewisse Regelhaftigkeiten bei den psycho-emotionalen Dynamiken feststellen. Das Wissen um diese – auch lange nach der eigentlichen Migration wirksamen – Prozesse hilft, psychische Störungen und seelisches Erleben, aber auch Ressourcen und Resilienzfaktoren von Menschen mit eigener oder familiärer Migrationsgeschichte im Kontext dieser zu verstehen.
Multikulturelle Orientierung als prozessorientierte therapeutische Haltung
Authors: Otyakmaz Berrin Özlem 
Published: February 2025

ZusammenfassungDer Beitrag befasst sich mit den konzeptionellen Grundlagen der Berücksichtigung kultureller Diversität in der Psychotherapie. Das vorgestellte Konzept der multikulturellen Orientierung mit Fokus auf prozessorientierte psychotherapeutische Haltungen versucht, Schwächen des vorhergehenden Ansatzes der multikulturellen Kompetenzen zu überwinden. Studien zur Psychotherapie-Prozessforschung bieten Hinweise für die empirische Fundierung des Konzeptes der multikulturellen Orientierung.
Mikroaggressionen im therapeutischen Kontext: erkennen, verstehen und bewältigen
Authors: Klein Eva M. , Slotta Timo , Wilker Sarah , Dumke Lars , Nohr Laura 
Published: February 2025

ZusammenfassungMikroaggressionen sind subtile, oft unbeabsichtigte Formen der Diskriminierung, die auch im therapeutischen Kontext weit verbreitet sind und die Arbeitsbeziehung negativ beeinflussen können. Das Erkennen und proaktive Ansprechen von Mikroaggressionen sind entscheidende Schritte, um einen möglichen Bruch in der therapeutischen Beziehung zu reparieren und Vertrauen herzustellen.
Reliability of Slice-Encoding for Metal Artifact Correction (SEMAC) MRI to Identify Prosthesis Loosening in Patients with Painful Knee Arthroplasty: A Prospective, Single-Center, Surgical Validation Study
Authors: Takahashi Tsuneari , Thaker Siddharth , Lettieri Giovanni , Redmond Anthony , Backhouse Michael R. , Stone Martin , O'Connor Philip J. , Pandit Hemant 
Published: February 2025

Abstract
Objectives To validate reliability of slice-encoding for metal artifact correction (SEMAC) sequences in identifying prosthesis loosening in patients with painful knee arthroplasties (KAs) by comparing SEMAC-magnetic resonance imaging (MRI) findings to surgical outcomes—the gold standard.
Materials and Methods We prospectively followed 44 painful KA patients with possible aseptic prosthesis loosening at our tertiary care institution from 2011 to 2017. Potential cases of infective loosening were excluded making ours a selective study population. We acquired conventional and SEMAC-MRI images for all patients on 1.5-T MRI scanner. Two consultants scored MRI findings for complications such as osteolysis and bone marrow edema systematically. Scoring variations were settled by consensus. We used the Mann–Whitney U test and Wilcoxon signed-rank test for quantitative analysis and Spearman's rank-order correlation for correlation analysis of SEMAC findings and surgical outcomes, and followed the Outcome Measurements in Rheumatology filter methodology to assess the ability of SEMAC-MRI to detect prosthetic loosening.
Results Eleven patients needed revision surgery—seven had prosthesis loosening and four had retained native compartment osteoarthritis. Thirty-three were treated conservatively, of which 17 had spontaneous pain resolution and 8 had extra-articular causes—referred pain from hip (1 patient) and lumbar (7 patients) degeneration. Eight patients had adequate pain control without prosthesis loosening on follow-up. T1W-SEMAC identified surgically proven prosthesis loosening in all cases and short tau inversion recovery (STIR)-SEMAC diagnosed bone marrow edema (BME) in all our true positive cases. Sensitivity, specificity, positive predictive value, and negative predictive value of SEMAC-MRI for component loosening compared with gold standard were 100, 97.0, 88.9, and 100% in T1W-SEMAC, 75.0, 45.5, 25.0, and 88.2% in STIR-SEMAC, and 75.0, 93.9, 75.0, and 93.9% in proton density-weighted-SEMAC.
Conclusion SEMAC-MRI can accurately detect surgically verifiable prosthesis loosening and differentiate nonspecific BME from prosthesis loosening.
History of the Treatment of Rectal Prolapse
Authors: Spivak Rebecca , Hu Katherine 
Published: February 2025

AbstractRectal prolapse is the intussusception of the rectum, resulting in its full-thickness protrusion out of the anus. Approximately 0.5% of the general population is affected by this condition, with a higher occurrence in women and the elderly. While benign, rectal prolapse can be debilitating, as it can cause pain, bleeding, mucus discharge, and fecal incontinence. The earliest documented records of rectal prolapse date back to Ancient Egypt (1500–1200 BC), describing laxatives and topical therapeutics for the treatment of an anus turned inside out. Many techniques were devised to hold the reduced prolapsed rectum in place, ranging from cords to the use of bandages. Surgical cauterization of the anal sphincter to prevent recurrent prolapse began as early as 6 BC in India, a practice that continued into the 1800s. Advances in fundamental understanding of the anatomy of the colon, rectum, and anus in the 19th and early 20th centuries paved the way for modern surgical approaches. The 20th century saw the development of procedures proposed by surgeons such as Delorme, Moschowitz, Ripstein, and Altemeier. The emergence of the laparoscopic rectopexy in 1992 and subsequent use of robotic-assisted techniques in the early 2000s marked the transition to modern rectal prolapse surgeries, improving both precision and outcomes. The overall management of rectal prolapse has evolved significantly from ancient remedies to the surgeries known today, yet some fundamental similarities remain consistent between today's outlook and what was documented centuries ago. Understanding the historical evolution of the diagnosis and treatment of rectal prolapse provides insight into the contemporary management of the disorder.
Investigating domain structures and superdomains in ferroelectric PbTiO3 based heterostructures on DyScO3
Authors: Tovaglieri L. , Hadjimichael M. , Torruella P. , Hsu C.-Y. , Korosec L. , Alexander D. T. L. , Paruch P. , Triscone J.-M. , Lichtensteiger C. 
Published: February 2025

This work focuses on the complex ferroelastic/ferroelectric domain structure in the prototypical ferroelectric PbTiO3 epitaxially strained on (110)o-oriented DyScO3 substrates, with a 22 nm-thick bottom SrRuO3 electrode. High quality epitaxial growth has been achieved from 7.2 nm (18 unit cells) up to 288 nm (720 unit cells) PbTiO3 film thickness. The evolution of the domain configuration and its scaling with the PbTiO3 film thickness are studied using a combination of atomic force microscopy, x-ray diffraction, piezoresponse force microscopy, and high resolution scanning transmission electron microscopy. A large asymmetry in the domain configuration is found due to the anisotropic strain imposed by the orthorhombic substrate. For thicker films, a larger scale arrangement of domains into superdomains is observed, with size that scales with the PbTiO3 film thickness, allowing a fine-tuning of their density. These superdomain structures affect the functional properties of the ferroelectric material and may play a role in switching devices such as memories. The presence of superdomains implies the existence of superdomain walls, which potentially exhibit properties intrinsically different from those of conventional ferroelastic or ferroelectric domain walls, opening the possibility of a new kind of superdomain wall-based nanoelectronics.
Corrigendum: A metriplectic formulation of polarized radiative transfer (2023 J. Phys. A: Math. Theor. 56 345206)
Authors: Bosboom V , Kraus M , Schlottbom M 
Published: February 2025

Abstract
In the article (Bosboom et al 2023 J. Phys. A: Math. Theor.
56 345206) we presented a metriplectic formulation for the radiative transfer equation with polarization. An important ingredient in this process was the construction of a suitable Lie bracket for matrix-valued functions. The bracket presented in equation (20) in Bosboom et al (2023 J. Phys. A: Math. Theor.
56 345206) is however not a Lie bracket since it does not satisfy the Jacobi identity. Here, we replace this bracket with a correct Lie bracket for matrix-valued functions and adjust the resulting proofs of the Jacobi identity of this bracket and the Casimir property of the entropy functional. All other results in the paper remain unaffected.