bluuebunny/crossref_metadata_2025_split huggingface dataset:
Surface Deformation Assessment due to the Grindulu Fault Activities using Sentinel 1 Data by Applying the Small Baseline Subset (SBAS)-InSAR Technique
Authors: Anjasmara Ira Mutiara , Timur Annisa Rahmawati , Agustin Fitriani 
Published: December 2023

Abstract
The location of Grindulu Fault is in the Pacitan Regency on the Southern Coast of Java, which directly faces the South Java Subduction zone. The activities of the fault could contribute to the surface deformation in the surrounding area. The Meteorology Climatology and Geophysics Council in Indonesia (BMKG) reported a 3.1 Mw earthquake on 7 November 2019, possibly related to the Grindulu fault activities. In this research, we assess the surface deformation around the Grindulu Fault using the Sentinel I data by applying the Small Baseline Subset (SBAS) - Interferometry Synthetic Aperture Radar (InSAR) technique. The SBAS-InSAR is one of the techniques that can provide spatial-temporal continuous analysis of the surface deformation over the extent of InSAR data. The SBAS algorithm was applied to twenty-three (23) ascending Sentinel-1B images to assess the surface deformation in Pacitan between 2019 and 2021 using the GMTSAR software. The results showed surface deformation dominated by subsidence over the whole area, except at the northern part of Grindulu Fault, with the mean velocity values ranging from -2.07 to -43.05 mm/yr.
Combined a Pressure Sensor and Internet of Things in a Low-Cost Tide Gauge
Authors: Pratomo Danar Guruh , Syah Muhammad Ardian 
Published: December 2023

Abstract
Tides are important in many fields, such as port planning, nautical charting, and bathymetry surveys. However, the distribution of tide observation stations in Indonesia is still uneven, so simple tidal data collection still uses tide palms to observe the movement of sea levels. The manual tidal observation method has limitations because visually the ability of the observer to see the tide reading is different, so it is subjective. Therefore, the solution to this problem is a tidal instrument that is easy to make, provides real-time data, and produces accurate information, saving energy and time. However, using automatic tide gauge instruments is still not affordable in the Indonesian market. This study creates a low-cost pressure tide gauge by integrating a pressure sensor with an Arduino microcontroller. In addition, the data monitoring process uses the Internet of Things system. Data from the instrument measurements were uploaded to the Thingspeak website live, allowing observers to monitor in real time. Instrument’s data with noise and anomalies will go through a data filtering process with the moving average and moving median methods. Testing the instrument’s error rate compares the data generated by the instrument with tidal data from the Indonesian Geospatial Agency (BIG). Both tidal data went through calculating Root Mean Square Error, or RMSE. Based on the instrument error test results, the RMSE value for moving average data against BIG is 27.963 cm and moving median data against BIG is 27.787 cm.
Parametric optimisation of a dual cantilever flutter for electromagnetic wind energy harvesting
Authors: Velusamy V R , Foong F M , Nik Mohd N A R , Thein C K 
Published: December 2023

Abstract
This paper investigates the parametric optimisation of dual cantilever flutter (DCF) beams for electromagnetic wind energy harvesting application. When two cantilever beams are placed side by side facing the direction of the wind flow, both beams would oscillate in an anti-phase motion once the critical flutter speed has been achieved. This arrangement is known as the DCF and it represents an ideal situation for energy harvesting through electromagnetic induction due to its anti-phase motion. Experimental results showed that the optimum load resistance value for the device is equivalent to a single-degree-of-freedom vibration energy harvester for low electromagnetic coupling case, despite the difference in the type of oscillations. Further analysis showed that there among the two possible arrangements for the magnets one arrangement results in a 51.5% larger magnetic flux density. It was seen that reducing the length of the electromagnetic DCF by 41.2% can increase the power output of the device by approximately six times, although the critical flutter speed also increased by 125.0%. Finally, some suggestions were provided on how to further improve the device.
Aerosol and surface contamination assessment of a novel ventilated infectious aerosol containment device
Authors: Fang Runcheng , Andrus Niles , Dominguez Thomas , Sleeth Darrah K , Jones Rachael M 
Published: December 2023

Abstract
Healthcare personnels (HCPs) are at risk of respiratory infectious diseases during patient care activities. HCPs rely primarily on personal protective equipment to prevent pathogen exposures, but there is a need to develop alternative, or complementary control strategies, including engineering controls. The objective of this study was to evaluate the ability of the 3 designs (denoted D1A, D1B, and D2) of the University of Utah Containment Ventilation for Exposure Reduction (U-COVER), a protective barrier enclosure device to contain respirable aerosols when placed over a simulated patient. The 2 primary performance metrics were the percent reduction in: (i) the concentration of respirable aerosols in the simulated breathing zone of an HCP, and (ii) surface contamination outside the device, which were tested using salt aerosols and fluorescein aerosols, respectively. Briefly, salt or fluorescein aerosols were generated as though expelled by a prone patient under 3 conditions: (i) no device (control), (ii) with the device but without exhaust ventilation, and (iii) with the device with exhaust ventilation. Device D2 was also tested under simulated use conditions, in which cardboard “arms” were placed inside the device ports. All 3 device designs showed the ability to reduce particle concentrations in the simulated HCP breathing zone and on surfaces by &gt;99% with exhaust ventilation compared to the control condition. Without exhaust ventilation, device performance was lower and highly variable. Under simulated use conditions, device D2 reduced particle concentrations in the simulated HCP breathing zone by ≥91% and on surfaces by &gt;99% relative to control for all combinations of “arms” tested. The U-COVER device demonstrates excellent aerosol containment and warrants further testing with dynamic simulated or actual use conditions.
Implant-Based Breast Reconstruction After Nipple-Sparing and Skin-Sparing Mastectomy in Breast-Augmented Patients: Prepectoral or Submuscular Direct-to-Implant Reconstruction?
Authors: Salgarello Marzia , Fabbri Mariachiara , Visconti Giuseppe , Barone Adesi Liliana 
Published: December 2023

Abstract

Background
Patients with breast augmentation facing a breast cancer diagnosis pose unique challenges for both breast and plastic surgeons in terms of treatment and reconstruction. Traditional submuscular direct-to-implant (DTI) breast reconstruction is often considered the standard approach, regardless of the previous implant pocket. However, recent trends in prepectoral reconstruction provide an innovative solution for patients with previous subglandular and submuscular implants.

Objectives
In this study we aimed to share our experiences with DTI breast reconstruction in patients with a history of breast augmentation, with a specific focus on the viability of prepectoral reconstruction.

Methods
A retrospective review was conducted on 38 patients with previous breast augmentation who underwent either skin-sparing mastectomy or nipple-sparing mastectomy for breast cancer followed by DTI reconstruction between January 2015 and July 2023. Our analysis considered various factors, including previous implant positioning, capsular and implant status, and mastectomy flap thickness (MFT), offering insights into the rationale behind choosing the new implant positioning.

Results
Patients with a history of subglandular breast augmentation and an MFT greater than 1 cm were candidates for prepectoral reconstruction. When the MFT was less than 1 cm but flap vascularity was sufficient, a prepectoral reconstruction was performed; otherwise, retropectoral reconstruction was preferred. Patients with submuscular breast augmentation were evaluated similarly, with submuscular reconstruction chosen when the MFT was less than 1 cm and prepectoral reconstruction preferred when the MFT exceeded 1 cm.

Conclusions
Immediate prepectoral DTI reconstruction represents a feasible option for specific patients with a history of breast augmentation. Decisions regarding the reconstructive approach are influenced by variables such as mastectomy flap thickness, implant status, and capsular conditions.

Level of Evidence: 3
Pelvic drain placement after robot-assisted radical prostatectomy: meta-analysis
Authors: Ma Jianglei , Chang Yifan , Xu Weidong , Cao Wanli , Zhang Zongqin , Lou Yihaoyun , Li Duocai , Ma Zifang , Jiang Junhui , Ren Shancheng 
Published: December 2023

Abstract

Background
It is not clear whether the routine placement of a pelvic drain after robot-assisted radical prostatectomy is a necessity. The aim of this study was to investigate this through a meta-analysis of RCTs and non-randomized studies.

Methods
A search was performed in PubMed/MEDLINE, Embase, the Cochrane Library, and the Web of Science, up to 9 March 2023, for clinical trials comparing no drain with pelvic drain placement for patients with prostate cancer after robot-assisted radical prostatectomy. Two researchers independently conducted literature screening, data extraction, and quality assessment. A random-effect model was assumed for all analyses. The Cochrane Collaboration’s risk-of-bias tool was used to evaluate the methodological quality of RCTs and, for non-randomized studies, the ROBINS-I tool was used (where ROBINS-I stands for Risk Of Bias In Non-randomized Studies - of Interventions). This meta-analysis was prospectively registered in PROSPERO, the international prospective register of systematic reviews (CRD42023406429).

Results
A total of six studies with 1480 patients were included in the meta-analysis. Both the meta-analysis of RCTs and the meta-analysis of non-randomized studies showed that patients without drains had a similar estimated blood loss (mean difference 40.49 ml, 95% c.i. −59.75 to 140.74 ml, P = 0.430, and mean difference −14.20 ml, 95% c.i. −32.26 to 3.87 ml, P = 0.120 respectively), overall complication rate (OR 0.60, 95% c.i. 0.35 to 1.04, P = 0.070, and OR 0.90, 95% c.i. 0.59 to 1.39, P = 0.640 respectively), Clavien–Dindo grade I–II complication rate (OR 0.62, 95% c.i. 0.34 to 1.13, P = 0.120, and OR 0.83, 95% c.i. 0.28 to 2.51, P = 0.750 respectively), Clavien–Dindo grade III–V complication rate (OR 0.60, 95% c.i. 0.10 to 3.69, P = 0.590, and OR 0.92, 95% c.i. 0.25 to 3.39, P = 0.900 respectively), and duration of hospital stay (mean difference −0.08 days, 95% c.i. −0.45 to 0.29 days, P = 0.670, and mean difference −0.64 days, 95% c.i. −2.67 to 1.39 days, P = 0.540 respectively) compared with routinely drained patients. Meta-analysis of non-randomized studies revealed that the duration of operation for patients without drains was shorter than that for patients with drains (mean difference −34.88 min, 95% c.i. −43.58 to –26.18 min, P &lt; 0.001), but the meta-analysis of RCTs indicated that there was no significant difference between the two groups (mean difference −7.64 min, 95% c.i. −15.61 to 0.32 min, P = 0.060).

Conclusion
The intraoperative and postoperative outcomes of patients without drains were not inferior to those of patients with drains. In selected patients, pelvic drains can be omitted after robot-assisted radical prostatectomy.
Neutrophil depletion attenuates antibody-mediated rejection in a renal transplantation mouse model
Authors: Li Xingku , Zhao Yakun , Sun Wenying , Zhang Cong , Yu Yadi , Du Bo , Jin AiShun , Liu Ye 
Published: December 2023

Abstract
Antibody-mediated rejection (AMR) can cause graft failure following renal transplantation. Neutrophils play a key role in AMR progression, but the exact mechanism remains unclear. We investigated the effect of neutrophils on AMR in a mouse kidney transplantation model. The mice were divided into five groups: syngeneic transplantation (Syn), allograft transplantation (Allo), and three differently treated AMR groups. The AMR mouse model was established using skin grafts to pre-sensitize recipient mice. Based on the AMR model, Ly6G-specific monoclonal antibodies were administered to deplete neutrophils (NEUT−/− + AMR) and TACI-Fc was used to block B-cell-activating factor (BAFF)/a proliferation-inducing ligand (APRIL) signaling (TACI-Fc + AMR). Pathological changes were assessed using hematoxylin–eosin and immunohistochemical staining. Banff values were evaluated using the Banff 2015 criteria. Donor-specific antibody (DSA) levels were assessed using flow cytometry, and BAFF and APRIL concentrations were measured using ELISA. Compared to the Syn and Allo groups, a significantly increased number of neutrophils and increased C4d and IgG deposition were observed in AMR mice, accompanied by elevated DSA levels. Neutrophil depletion inhibited inflammatory cell infiltration and reduced C4d and IgG deposition. Neutrophil depletion significantly decreased DSA levels after transplantation and suppressed BAFF and APRIL concentrations, suggesting a mechanism for attenuating AMR-induced graft damage. Similar results were obtained after blockading BAFF/APRIL using a TACI-Fc fusion protein. In summary, neutrophil infiltration increased in the AMR mouse renal transplantation model. Neutrophil depletion or blockading the BAFF/APRIL signaling pathway significantly alleviated AMR and may provide better options for the clinical treatment of AMR.
Comparative metatranscriptomics reveals effect of host plant on microbiota gene expression of Anastrepha obliqua (Diptera: Tephritidae) larvae
Authors: Cárdenas-Hernández Valentina , Lemos-Lucumí César Alejandro , Toro-Perea Nelson 
Published: December 2023

Abstract
The microbiota associated with phytophagous insects perform several functions that help insects exploit plant resources. Thus, microorganisms contribute to the dispersal of phytophagous species to new host plants, thereby promoting diversification. In this study, metatranscriptomic analysis was used to compare the gene expression of the microbiome of Anastrepha obliqua Macquart larvae feeding on 3 of its host plants: Spondias purpurea L (red mombin), Mangifera indica L (mango), and Averrhoa carambola L (starfruit). To identify differential gene expression in relation to the host plant, transcript abundance was compared. The results of the taxonomic and functional beta-diversity analysis showed that there were significant differences in the structures and activities of the microbial communities depending on the infested plant. Among the microorganisms, bacteria and fungi were active components of the microbiota. Differential expression analyses showed that the different active genes in each of the plants analyzed were mainly grouped into categories related to carbohydrate and amino acid metabolism, with some of these genes coding for cytochrome o ubiquinol oxidase, cytochrome c, and the enzyme isocitrate dehydrogenase. The microbiota of A. carambola larvae differed more at the level of community structure and gene function, possibly due to the different nutritional composition of the A. carambola and the presence of a set of secondary metabolites specific to the family Oxalidaceae. In conclusion, the transcriptional activity of the microbiota of A. obliqua larvae is influenced by diet, which is important because it could influence the performance of the insect on each of its different host plants.
Multiple generation distinct toxicant exposures induce epigenetic transgenerational inheritance of enhanced pathology and obesity
Authors: Nilsson Eric E , McBirney Margaux , De Santos Sarah , King Stephanie E , Beck Daniel , Greeley Colin , Holder Lawrence B , Skinner Michael K 
Published: December 2023

Abstract
Three successive multiple generations of rats were exposed to different toxicants and then bred to the transgenerational F5 generation to assess the impacts of multiple generation different exposures. The current study examines the actions of the agricultural fungicide vinclozolin on the F0 generation, followed by jet fuel hydrocarbon mixture exposure of the F1 generation, and then pesticide dichlorodiphenyltrichloroethane on the F2 generation gestating females. The subsequent F3 and F4 generations and F5 transgenerational generation were obtained and F1–F5 generations examined for male sperm epigenetic alterations and pathology in males and females. Significant impacts on the male sperm differential DNA methylation regions were observed. The F3–F5 generations were similar in ∼50% of the DNA methylation regions. The pathology of each generation was assessed in the testis, ovary, kidney, and prostate, as well as the presence of obesity and tumors. The pathology used a newly developed Deep Learning, artificial intelligence-based histopathology analysis. Observations demonstrated compounded disease impacts in obesity and metabolic parameters, but other pathologies plateaued with smaller increases at the F5 transgenerational generation. Observations demonstrate that multiple generational exposures, which occur in human populations, appear to increase epigenetic impacts and disease susceptibility.
Impact of participation as a peer change agent on peer change agents themselves: a quantitative study of a peer-led, social media-based PrEP promotion intervention
Authors: Cooper Spring C , Santella Anthony J , Caines Matthew , Rojanaworarit Chanapong , Hernandez Alex 
Published: December 2023

Abstract
Despite the adoption of pre-exposure prophylaxis (PrEP) as a crucial HIV intervention, uptake remains suboptimal among men who have sex with men, a sexual minority group, due to barriers like cost and stigma. Peer change agents (PCAs) disseminate PrEP information within their social networks. This study explores the reciprocal effects of an online community-based participatory intervention on PCAs, focusing on their transformed PrEP uptake perceptions—leadership efficacy, social network dynamics, attitudes, perceived benefits and barriers and self-efficacy. Leveraging insights from the PrEP Chicago Study, our research addresses a key gap in community-based participatory interventions for PrEP uptake: the transformative experiences and perception shifts of PCAs involved in these interventions. We engaged 20 men who have sex with men, aged 18–45, as PCAs in a one-group pretest–posttest design intervention, which disseminated PrEP communications within their preferred online networks. We utilized the PrEP Chicago Study’s 45 Likert items, tailored to reveal the PCAs’ transformative potential. Data on PrEP uptake perceptions, sociodemographics and social media use were captured and analyzed using the Wilcoxon matched-pairs signed-rank test, a nonparametric method. PCAs demonstrated significant changes in their PrEP uptake perceptions, including leadership capacity, social network dynamics, attitudes toward PrEP, perceived benefits, barriers and self-efficacy. Our intervention highlights the reciprocal transformation PCAs undergo when disseminating PrEP information. This study adds a new dimension to community-based PrEP interventions and underscores the need for continued refinement of peer-led strategies to optimize the transformative potential of PCAs.
Vaccination Shapes Within-Host SARS-CoV-2 Diversity of Omicron BA.2.2 Breakthrough Infection
Authors: Zhang Yi , Zhou Yang , Chen Jiazhen , Wu Jing , Wang Xun , Zhang Yumeng , Wang Shiyong , Cui Peng , Xu Yuanyuan , Li Yang , Shen Zhongliang , Xu Tao , Zhang Qiran , Cai Jianpeng , Zhang Haocheng , Wang Pengfei , Ai Jingwen , Jiang Ning , Qiu Chao , Zhang Wenhong 
Published: December 2023

Abstract

Background
Low-frequency intrahost single-nucleotide variants of SARS-CoV-2 have been recognized as predictive indicators of selection. However, the impact of vaccination on the intrahost evolution of SARS-CoV-2 remains uncertain at present.

Methods
We investigated the genetic variation of SARS-CoV-2 in individuals who were unvaccinated, partially vaccinated, or fully vaccinated during Shanghai's Omicron BA.2.2 wave. We substantiated the connection between particular amino acid substitutions and immune-mediated selection through a pseudovirus neutralization assay or by cross-verification with the human leukocyte antigen–associated T-cell epitopes.

Results
In contrast to those with immunologic naivety or partial vaccination, participants who were fully vaccinated had intrahost variant spectra characterized by reduced diversity. Nevertheless, the distribution of mutations in the fully vaccinated group was enriched in the spike protein. The distribution of intrahost single-nucleotide variants in individuals who were immunocompetent did not demonstrate notable signs of positive selection, in contrast to the observed adaptation in 2 participants who were immunocompromised who had an extended period of viral shedding.

Conclusions
In SARS-CoV-2 infections, vaccine-induced immunity was associated with decreased diversity of within-host variant spectra, with milder inflammatory pathophysiology. The enrichment of mutations in the spike protein gene indicates selection pressure exerted by vaccination on the evolution of SARS-CoV-2.
Impact of possible errors in natural language processing-derived data on downstream epidemiologic analysis
Authors: Lan Zhou , Turchin Alexander 
Published: December 2023

Abstract

Objective
To assess the impact of potential errors in natural language processing (NLP) on the results of epidemiologic studies.

Materials and Methods
We utilized data from three outcomes research studies where the primary predictor variable was generated using NLP. For each of these studies, Monte Carlo simulations were applied to generate datasets simulating potential errors in NLP-derived variables. We subsequently fit the original regression models to these partially simulated datasets and compared the distribution of coefficient estimates to the original study results.

Results
Among the four models evaluated, the mean change in the point estimate of the relationship between the predictor variable and the outcome ranged from −21.9% to 4.12%. In three of the four models, significance of this relationship was not eliminated in a single of the 500 simulations, and in one model it was eliminated in 12% of simulations. Mean changes in the estimates for confounder variables ranged from 0.27% to 2.27% and significance of the relationship was eliminated between 0% and 9.25% of the time. No variables underwent a shift in the direction of its interpretation.

Discussion
Impact of simulated NLP errors on the results of epidemiologic studies was modest, with only small changes in effect estimates and no changes in the interpretation of the findings (direction and significance of association with the outcome) for either the NLP-generated variables or other variables in the models.

Conclusion
NLP errors are unlikely to affect the results of studies that use NLP as the source of data.