bluuebunny/crossref_metadata_2025_split huggingface dataset:
Origin traceability and adulteration detection of soybean using near infrared hyperspectral imaging
Authors: Li Xue , Wang Du , Yu Li , Ma Fei , Wang Xuefang , Pérez‐Marín Dolores , Li Peiwu , Zhang Liangxiao 
Published: January 2024

AbstractStable isotopes, multi‐elements, metabolic profiles, and integrated spectroscopic fingerprints are priority options for food geographical origin traceability. However, til now, it is still hard to detect adteration with the same one from other geographic origins, which is harder than geographical origin traceability. In this study, partial least square discriminant analysis was employed to build a classification model to discriminate the domestic and imported soybeans after variable selection by uninformative variable elimination using near infrared hyperspectral imaging. As a result, this model could completely discriminate domestic and imported soybeans. Moreover, the developed model was used to detect the adulterated domestic soybean was adulterated with 13.3%, 20.0%, 26.7%, and 33.3% of imported soybean. When the skewness value was less than 0.76 and kurtosis value was less than 1.57 of a sample, the sample was considered as the adulterated. The results indicated that the domestic soybeans adulterated with 20.0%, 26.7%, and 33.3% of imported soybeans were successfully identified. This method could not only identify origin traceability but also detect adulteration of soybeans, which will be beneficial to guarantee the quality and safety of soybean.
The effects of blueberry (Vaccinium corymbosum L.) and jujube fruit (Ziziphus jujube) on physicochemical, functional, and sensorial properties, and probiotic (Lactobacillus acidophilusDSM 20079) viability of probiotic ice cream
Authors: Şentürk Gülsüm , Akın Nihat , Konak Göktepe Çiğdem , Denktaş Begüm 
Published: January 2024

AbstractThe effects of blueberry (BB) and jujube fruit (JF) on the quality parameters, functional, probiotic (Lactobacillus acidophilus DSM 20079) viability, and sensorial properties of probiotic ice cream were investigated. No statistical differences were discovered regarding titratable acidity and L. acidophilus DSM 20079 counts between all samples. However, the ice creams preserved the survivability of probiotic bacteria during the storage period. The probiotic ice creams had counts of viable L. acidophilus DSM 20079 ranging from 8.42 to 8.80 log CFU/g which met the minimum required to achieve probiotic effects after 60 days of storage. Probiotic ice cream with BB or JF had significantly lower L* values than the control, and the BB addition caused the greatest decrease. The addition of both fruits clearly enhanced the total phenolic content and antioxidative activity in ice cream. The incorporation of BB or JF into the ice creams did not statistically affect the overrun value, while the addition of both fruits dramatically affected the first dripping time and increased hardness. Overall, sensory attributes were not significantly altered by the fortification of either fruit relative to the control, so these fruits can be added at higher concentrations to ice cream formulations for further studies.
Prognostic value of preoperative inflammatory ratios in early glottic cancer treated with transoral laser surgery
Authors: Juesas Iglesias Luis , Sánchez‐Canteli Mario , Pedregal Mallo Daniel , Otero‐Rosales María , López Fernando , García‐Pedrero Juana M. , Rodrigo Juan P. 
Published: January 2024

AbstractBackgroundThere is growing evidence regarding the prognostic utility of ratios such as neutrophil‐to‐lymphocyte ratio (NLR), platelet‐to‐lymphocyte ratio (PLR), and systemic immune‐inflammatory index (SIII) in head and neck squamous cell carcinoma (HNSCC). However, most studies to date include heterogeneous series with different treatments or tumor subsites.MethodsWe collected data from 201 patients with stage I–II glottic squamous cell carcinoma treated with transoral laser surgery. NLR, PLR, and SIII were calculated from preoperative cell blood count, cut‐off points were obtained by ROC curve analysis, and survival rates were calculated.ResultsHigh NLR (p = 0.012) and SIII (p = 0.037), but not PLR (p = 0.48), were associated with worse disease‐specific survival (DSS). A similar trend was observed with overall survival (OS), although it did not reach statistical significance. On multivariable analyses, both high NLR (HR = 3.8, 95% CI = 1.5–9.9, p = 0.006) and high SIII (HR = 2.77, 95% CI = 1.1–6.9, p = 0.03) were significantly associated with shortened DSS.ConclusionsPreoperative NLR and SIII emerge as independent prognostic biomarkers for early‐stage surgically treated glottic tumors and could guide individualized follow‐up.
Risk spillover measurement of carbon trading market considering susceptible factors: A network perspective
Authors: Dong Qingli , Lian Lanlan , Jiang Qichuan 
Published: January 2024

AbstractAn objective and robust network‐based data‐driven strategy is proposed to analyze risk spillovers in carbon markets. First, we characterize the causality network between the carbon market and potential associated markets using a data‐driven fuzzy cognitive map approach. Second, network‐based community detection is conducted to explore community structures that include carbon trading markets, and five market factors belonging to the same community as EU Allowances (EUA) are identified. Next, we conduct downside and upside‐tail measurements of EUA risk spillover levels within the community based on estimates and fits of marginal and joint distributions for different market pairs. Finally, we point out that the market factor having the most significant upper‐tail spillover effects on EUA is OILFUTURE, besides, EURUSD asset is found to be the best hedge for EUA futures among the detected market factors.
Bisphenol A and polycystic ovary syndrome in human: A systematic review
Authors: Urbanetz Lorena Ana Mercedes Lara , Soares‐Junior José Maria , dos Santos Simões Ricardo , Maciel Gustavo Arantes Rosa , Baracat Maria Candida Pinheiro , Baracat Edmund Chada 
Published: January 2024

AbstractBackgroundPolycystic ovary syndrome (PCOS) is an endocrine disorder characterized by anovulation, hyperandrogenism, and polycystic ovarian morphology. Its etiology is uncertain and one of the hypotheses is that environmental factors, such as the bisphenol A (BPA) endocrine disruptor, may be involved.ObjectiveTo investigate the association between exposure to BPA and PCOS.Search StrategyResearch was conducted focusing on studies published in English, Portuguese, and Spanish from January 2001 to March 2023 and available in Embase, Medline/PubMed, Rima, Lilacs, Scielo, Google academic, and SCI databases.Selection CriteriaStudies in humans that evaluated the association between exposure to BPA and a diagnosis of PCOS.Data Collection and AnalysisFollowing PRISMA guidelines, study characteristics and relevant data were extracted.Main ResultsSelection of 15 case–control and 7 cross‐sectional studies with a total of 1682 PCOS patients. The studies were carried out in China, Poland, Turkey, Japan, Greece, Italy, the USA, Iran, Iraq, Egypt, India, Czechia, and Slovakia. A positive relationship between exposure to BPA and PCOS was described in19 studies (1391 [82.70%] of the PCOS patients). The fluids used in the studies were serum, urine, plasma, and follicular fluid. BPA was measured by ELISA and by chromatography (HPLC, HPLC‐MS/MS, GC–MS, and GC–MS/MS). Diagnosis of PCOS used Rotterdam criteria in 15, NIH 1999 in 3, AE&PCOS Society in 2, similar to the Rotterdam criteria in 1, and criteria not informed in 1. Androgens were measured in 16 studies; in 12, hyperandrogenism was positively associated with BPA. BPA level was related to body mass index (BMI) in studies. In 15 studies independently of BMI, women with PCOS had higher BPA levels. Carbohydrate metabolism disorders were evaluated in 12 studies and in 6 a positive correlation was found with BPA levels. Lipid profile was evaluated in seven studies and in only one the correlation between lipid profile and BPA levels was present.ConclusionsExposure to BPA is positively associated with PCOS, mainly with the hyperandrogenism.
Health information systems in extreme contexts: Using mobile phones to fight AIDS in Uganda
Authors: Njuba Livingstone , Gómez‐Morantes Juan E. , Herrera Andrea , Camacho Sonia 
Published: January 2024

AbstractThe HIV/AIDS pandemic is a global issue that has unequally affected several countries. Due to the complexity of this condition and the human drama it represents to those most affected by it, several fields have contributed to solving or at least alleviating this situation, and the information systems (IS) field has not been absent from these efforts. With the importance of antiretroviral therapy (ART) as a starting point, several initiatives in the IS field have focused on ways to improve the adherence and effectiveness of this therapy: mobile phone reminders (for pill intake and appointments), and mobile interfaces between patients and health workers are popular contributions. However, many of these solutions have been difficult to implement or deploy in some countries in the Global South, which are among the most affected by this pandemic. This paper presents one such case. Using a case‐study approach with an extreme‐case selection technique, the paper studies an m‐health system for HIV patients in the Kalangala region of Uganda. Using Heeks' design—reality gap model for data analysis, the paper shows that the rich interaction between social context and technology should be considered a central concern when designing or deploying such systems.
Interleukin‐38 alleviates hepatic steatosis through AMPK/autophagy‐mediated suppression of endoplasmic reticulum stress in obesity models
Authors: Sun Jaw Long , Cho Wonjun , Oh Heeseung , Abd El‐Aty A. M. , Hong Soon Auck , Jeong Ji Hoon , Jung Tae Woo 
Published: January 2024

AbstractInterleukin‐38 (IL‐38), recently recognized as a cytokine with anti‐inflammatory properties that mitigate type 2 diabetes, has been associated with indicators of insulin resistance and nonalcoholic fatty liver disease (NAFLD). This study investigated the impact of IL‐38 on hepatic lipid metabolism and endoplasmic reticulum (ER) stress. We assessed protein expression levels using Western blot analysis, while monodansylcadaverine staining was employed to detect autophagosomes in hepatocytes. Oil red O staining was utilized to examine lipid deposition. The study revealed elevated serum IL‐38 levels in high‐fat diet (HFD)‐fed mice and IL‐38 secretion from mouse keratinocytes. IL‐38 treatment attenuated lipogenic lipid accumulation and ER stress markers in hepatocytes exposed to palmitate. Furthermore, IL‐38 treatment increased AMP‐activated protein kinase (AMPK) phosphorylation and autophagy. The effects of IL‐38 on lipogenic lipid deposition and ER stress were nullified in cultured hepatocytes by suppressing AMPK through small interfering (si) RNA or 3‐methyladenine (3MA). In animal studies, IL‐38 administration mitigated hepatic steatosis by suppressing the expression of lipogenic proteins and ER stress markers while reversing AMPK phosphorylation and autophagy markers in the livers of HFD‐fed mice. Additionally, AMPK siRNA, but not 3MA, mitigated IL‐38‐enhanced fatty acid oxidation in hepatocytes. In summary, IL‐38 alleviates hepatic steatosis through AMPK/autophagy signaling‐dependent attenuation of ER stress and enhancement of fatty acid oxidation via the AMPK pathway, suggesting a therapeutic strategy for treating NAFLD.
Cold‐induced skin darkening does not protect amphibian larvae from UV‐associated DNA damage
Authors: Hird Coen , Flanagan Emer , Franklin Craig E. , Cramp Rebecca L. 
Published: January 2024

AbstractAmphibian declines are sometimes correlated with increasing levels of ultraviolet radiation (UVR). While disease is often implicated in declines, environmental factors such as temperature and UVR play an important role in disease epidemiology. The mutagenic effects of UVR exposure on amphibians are worse at low temperatures. Amphibians from cold environments may be more susceptible to increasing UVR. However, larvae of some species demonstrate cold acclimation, reducing UV‐induced DNA damage at low temperatures. Understanding of the mechanisms underpinning this response is lacking. We reared Limnodynastes peronii larvae in cool (15°C) or warm (25°C) waters before acutely exposing them to 1.5 h of high intensity (80 µW cm−2) UVBR. We measured the color of larvae and mRNA levels of a DNA repair enzyme. We reared larvae at 25°C in black or white containers to elicit a skin color response, and then measured DNA damage levels in the skin and remaining carcass following UVBR exposure. Cold‐acclimated larvae were darker and displayed lower levels of DNA damage than warm‐acclimated larvae. There was no difference in CPD‐photolyase mRNA levels between cold‐ and warm‐acclimated larvae. Skin darkening in larvae did not reduce their accumulation of DNA damage following UVR exposure. Our results showed that skin darkening does not explain cold‐induced reductions in UV‐associated DNA damage in L. peronii larvae. Beneficial cold‐acclimation is more likely underpinned by increased CPD‐photolyase abundance and/or increased photolyase activity at low temperatures.
Synthesis and antiviral activity of novel imidazo[2,1‐b]thiazoles coupled with morpholine and thiomorpholines
Authors: Chirra Nagaraju , Shanigarapu Varshitha , Abburi Naga Pranathi , Sinegubova Ekaterina O. , Pedapati Ravi Kumar , Esaulkova Yana L. , Zarubaev Vladimir V. , Kantevari Srinivas 
Published: January 2024

AbstractHerein described the synthesis and antiviral evaluation of a novel series of morpholine and thio‐morpholine coupled imidazo[2,1‐b]thiazoles. The three‐step reaction sequence involving the condensation of 1,3‐dichloroacetone with thiourea followed by coupling with morpholine and thiomorpholine and finally cyclization with substituted α‐bromoacetophenones yielded the desired imidazothiazoles 7(a–l). Screening of all the new compounds for their in vitro antiviral activity against influenza virus A/Puerto Rico/8/34 (H1N1) in MDCK cells, resulted in two potent analogs, 7d (IC50: 1.1 μM, C50: >300 μM, SI = 273) and 7e (IC50: 2.0 μM, C50: >300 μM, SI = 150), with a favorable toxicity profile and are the best anti‐influenza hit analogs for further structural optimization.
Biochar application induces different responses of bacterial and fungal communities to metabolic limitation
Authors: Yang Jiayan , Lei Jinyin , Zhang Fengbao , Li Yuanyuan , Gao Jingxia , Deng Lei , Yang Mingyi 
Published: January 2024

AbstractBiochar, an environmentally friendly soil amendment, has the potential to alleviate soil degradation. However, the mechanisms and effects of biochar addition on soil microbes and metabolic limitation in degraded soils are still ambiguous because of the complex ecosystem and the varying conditions of planting. Therefore, a field experiment with six biochar application rates (0, 24, 60, 96, 132, and 168 Mg ha−1, applied in the 0–20 cm soil layer) was conducted in a loessial soil without planting to determine the response of metabolic limitation and the microbial community to the biochar application rate. Soil samples were collected in mid‐May and mid‐August (before and during the rainy season). The results showed that the soil microbial metabolic activity without biochar application was phosphorus (P) limited in mid‐May (vector angle = 81.37 ± 0.31°) and nitrogen (N) limited in mid‐August (vector angle = 27.36 ± 1.54°), and nutrient limitations generally decreased in the biochar treatments. Structural equation modeling indicated that microbial metabolic restriction was mainly influenced by biochar‐induced changes in element stoichiometric ratios and available phosphorus (p < 0.05). Under the influence of biochar content, only the carbon (C) limitation influenced bacterial composition by directly or indirectly affecting dissolved organic carbon and NO3−–N. However, the fungal composition was strongly shaped by both C limitation and P/N limitation. Our results indicated that the soil P status and its stoichiometric ratios play an important role in the biochar effects on metabolic limitation and that bacteria and fungi have different compositional responses to metabolic limitation in loessial soil.
The impact of reducing trade barriers on enterprises' pollution emissions: Evidence from China
Authors: Hong Lianying , Liu Xujun , Liu Bei , Cao Kewei , Xia Qiu 
Published: January 2024

AbstractTrade and pollution are important issues for people's well‐being. However, less attention has been paid to the study of changes in international trade rules affecting the emission behavior of micro firms. This paper takes the quota restriction of the multi‐fiber arrangement (MFA) lifted as an exogenous impact and explores the impact of trade barriers reduction on pollution emissions of textile industries using the difference‐in‐differences (DID) method. The results show that (1) after the quota restriction of the MFA was lifted, the reduction of trade barriers increased the pollution emissions of the textile industry. The enterprises' SO2 emission intensity with trade barriers reduced increases by 8.1% compared to the industries with trade barriers that have not been reduced. (2) The impact of the trade barrier reduction on enterprises' pollution emissions varies with the type of enterprise ownership, export nature, and enterprise scale. For private enterprises, export enterprises, and large‐scale enterprises, the promotion effect of trade barrier reduction on enterprises' pollution emissions is more significant. (3) The mechanism test results show that the increase in SO2 emission intensity is mainly caused by the increase in the market share of enterprises, the deterioration of energy structure, and the increase in pollution output of enterprises. Therefore, it is critical to reduce enterprises' pollution emissions by maintaining a reasonable market share, optimizing energy structures, and increasing investment in pollution treatment equipment. This study reveals that changes in MFA international trade rules have profoundly influenced the production decision‐making behavior of companies in exporting countries, producing deep implications for enterprise pollution emission behavior and providing empirical evidence and management guidance for developing countries' development of environmentally friendly trade policies and responses to trade‐induced environmental pollution shocks.
Rethinking Movement Disorders
Authors: Münchau Alexander , Klein Christine , Beste Christian 
Published: January 2024

AbstractAt present, clinical practice and research in movement disorders (MDs) focus on the “normalization” of altered movements. In this review, rather than concentrating on problems and burdens people with MDs undoubtedly have, we highlight their hidden potentials. Starting with current definitions of Parkinson's disease (PD), dystonia, chorea, and tics, we outline that solely conceiving these phenomena as signs of dysfunction falls short of their complex nature comprising both problems and potentials. Such potentials can be traced and understood in light of well‐established cognitive neuroscience frameworks, particularly ideomotor principles, and their influential modern derivatives. Using these frameworks, the wealth of data on altered perception‐action integration in the different MDs can be explained and systematized using the mechanism‐oriented concept of perception‐action binding. According to this concept, MDs can be understood as phenomena requiring and fostering flexible modifications of perception‐action associations. Consequently, although conceived as being caught in a (trough) state of deficits, given their high flexibility, people with MDs also have high potential to switch to (adaptive) peak activity that can be conceptualized as hidden potentials. Currently, clinical practice and research in MDs are concerned with deficits and thus the “deep and wide troughs,” whereas “scattered narrow peaks” reflecting hidden potentials are neglected. To better delineate and utilize the latter to alleviate the burden of affected people, and destigmatize their conditions, we suggest some measures, including computational modeling combined with neurophysiological methods and tailored treatment. © 2024 International Parkinson and Movement Disorder Society.
Design and analysis of dual‐band plasmonic band pass filter using meandering step impedance resonator
Authors: Chityala Ravi Kiran , Aryal Arjun , Osman Pathan , Sridevi Padavala Veera , Chityala Yashaswi 
Published: January 2024

AbstractIn this article, we demonstrated the minimum significant dielectric thickness of silicon dioxide (SiO2) below the diffraction limit for the confinement in the metal–insulator–metal (MIM) waveguide and utilizing this idea, we further exhibited the detail design analysis of dual‐band plasmonic meandering step impedance resonator (MSIR), which can achieve a high quality‐factor compared to a traditional step impedance resonator (SIR). MSIRs have sharper wavelength selectivity compared to SIRs, making them more suitable for applications that require precise wavelength tuning. The tunability of reflection and transmission characteristics with respect to design parameters has been reported. The designed MSIR has demonstrated a good passband response at wavelengths λ = 1414‐nm (E‐band) and 1577‐nm (L‐band) as well as turnability with design parameters. This filter achieved a large frequency spectral range of 139 nm and a high Q factor of ~3 × 104. This work enhances the capability of on‐chip filtering in the plasmonic platform.
ECG‐free cine MRI with data‐driven clustering of cardiac motion for quantification of ventricular function
Authors: Ming Zhengyang , Pogosyan Arutyun , Gao Chang , Colbert Caroline M. , Wu Holden H. , Finn J. Paul , Ruan Dan , Hu Peng , Christodoulou Anthony G. , Nguyen Kim‐Lien 
Published: January 2024

BackgroundDespite the widespread use of cine MRI for evaluation of cardiac function, existing real‐time methods do not easily enable quantification of ventricular function. Moreover, segmented cine MRI assumes periodicity of cardiac motion. We aim to develop a self‐gated, cine MRI acquisition scheme with data‐driven cluster‐based binning of cardiac motion.MethodsA Cartesian golden‐step balanced steady‐state free precession sequence with sorted k‐space ordering was designed. Image data were acquired with breath‐holding. Principal component analysis and k‐means clustering were used for binning of cardiac phases. Cluster compactness in the time dimension was assessed using temporal variability, and dispersion in the spatial dimension was assessed using the Caliński–Harabasz index. The proposed and the reference electrocardiogram (ECG)‐gated cine methods were compared using a four‐point image quality score, SNR and CNR values, and Bland–Altman analyses of ventricular function.ResultsA total of 10 subjects with sinus rhythm and 8 subjects with arrhythmias underwent cardiac MRI at 3.0 T. The temporal variability was 45.6 ms (cluster) versus 24.6 ms (ECG‐based) (p < 0.001), and the Caliński–Harabasz index was 59.1 ± 9.1 (cluster) versus 22.0 ± 7.1 (ECG based) (p < 0.001). In subjects with sinus rhythm, 100% of the end‐systolic and end‐diastolic images from both the cluster and reference approach received the highest image quality score of 4. Relative to the reference cine images, the cluster‐based multiphase (cine) image quality consistently received a one‐point lower score (p < 0.05), whereas the SNR and CNR values were not significantly different (p = 0.20). In cases with arrhythmias, 97.9% of the end‐systolic and end‐diastolic images from the cluster approach received an image quality score of 3 or more. The mean bias values for biventricular ejection fraction and volumes derived from the cluster approach versus reference cine were negligible.ConclusionECG‐free cine cardiac MRI with data‐driven clustering for binning of cardiac motion is feasible and enables quantification of cardiac function.