bluuebunny/crossref_metadata_2025_split huggingface dataset:
Flavor profiling and gene expression studies of indigenous aromatic rice variety (Mushk Budiji) grown at different altitudes of Highland Himalayan regions
Authors: Fayaz Ufaq , Hussain Syed Zameer , Naseer Bazila , Mahdi Syed Sheraz , Mir Javid Iqbal , Ghosh Alokesh , Jana Arun , Wani Nazrana Rafique , Jabeen Abida , Wani Fehim J. , Manzoor Sobiya 
Published: January 2024

AbstractMushk Budiji-an indigenous aromatic rice variety is usually grown at an altitude ranging from 5000 to 7000 ft above mean sea level in Highland Himalayas. This study was conducted to investigate the effects of altitude, soil nitrogen content and climatic conditions (temperature) of the selected locations on the flavor profile of Mushk Budiji using gas chromatography-mass spectroscopy (GC–MS) and electronic nose (E-nose). E-nose being rapid and non-destructive method was used to validate the results of volatile aromatic compounds obtained using GC–MS in Mushk Budiji. Around 35 aromatic compounds were identified in Mushk Budiji rice samples. Highest volatile peak area percentage (105.41%) was recorded for Mushk Budji grown at an altitude of 5216.53 ft. Highest E-nose score (2.52) was obtained at an altitude of 6299.21 ft. Over-expression of fatty acid degradation and linoleic acid metabolism genes was observed at higher altitudes, whereas lipid biosynthesis was negatively influenced by higher altitude. Fatty acid degradation and linoleic acid metabolism is responsible for the synthesis of volatile aromatic compounds in Mushk Budiji. This study will therefore be the path finder for investigating the intricate mechanism behind the role of altitude on aroma development in Mushk Budiji rice for future studies.
Quality variations of leachate resulting from cigarette filter recycling as a challenge for its management
Authors: Hossaini Motlagh Amin , Alinejad Navid , Kazembeigi Farogh , Torkashvand Javad , Tashauoei Hamid Reza , Fattahi Mehdi 
Published: January 2024

AbstractRecycling is known as a solution for cigarette filter management, but this may cause the release of trapped pollutants in it. Cigarette smoke toxins and chemicals that trapped in the cigarette filter can accumulate in the recycling leachate. In this study, littered cigarette filters and freshly smoked cigarette filters were recycled and the resulting leachate was analyzed. The results showed that the minimum and maximum Chemical Oxygen Demand (COD) of the studied leachates were 2100 mg/L and 11,300 mg/L, respectively. The maximum temporal variation in the studied leachate quality was 74.28%, but the maximum spatial variation was 314.2%. COD in the freshly smoked sample was 2600–9200 mg/L more than the littered samples. The average concentration of chromium, lead, nickel, and cadmium in littered samples was 0.023, 0.024, 0.045, and 0.019 mg/L, respectively. Environmental conditions such as humidity, the efficiency of the urban cleaning system in reducing the resistance of littered filters, the difference in the quality of the filter and tobacco, and the difference in smoking behaviors were effective in this variation. Reducing the toxicity of cigarette smoke and improving the efficiency of the urban cleaning system can lead to the same quality, but leachate treatment is necessary to reduce the environmental risk.
Non-isolated high gain DC–DC converter with ripple-free source current
Authors: Valarmathy A. S. , Prabhakar M. 
Published: January 2024

AbstractIn this paper, an interleaved DC–DC converter with high voltage gain capability is presented. The proposed converter is synthesized from a coupled-inductor (CI) based interleaved boost converter (IBC). For enhancing the voltage gain capability, voltage-lift capacitor, and diode-capacitor multiplier (DCM) cells are employed at the primary and secondary sides of the CIs. The proposed hybrid gain extension concept is practically validated using simulation and experimentation. A 185W prototype version of the proposed converter is switched at 50 kHz under laboratory conditions from a 18 V input to realize 380 V at the output port. The switches in the proposed converter operate at 0.5 duty ratio and experience a very low voltage stress of only 10.5% of the output voltage. Moreover, due to the interleaving mechanism, the input current ripple is just 11% of the total input current and the current rating of the switches is halved. Due to the adopted gain extension mechanism, the voltage stress on almost all the diodes is also significantly reduced. The swift dynamic response of the converter under closed-loop conditions is also practically demonstrated. Further, the beneficial features of the proposed converter are clearly validated by benchmarking its parameters with many state-of-the art converters which are available in literature.
Global land drought hubs confounded by teleconnection hotspots in equatorial oceans
Authors: Chauhan Tejasvi , Chandel Vikram , Ghosh Subimal 
Published: January 2024

AbstractEmerging data-driven techniques, such as Complex Networks (CNs), can identify spatial linkages between droughts on a global scale and can improve early warning systems. Recent studies used CNs to identify hotspots of global drought teleconnections as land drought hubs; however, these studies excluded the ocean regions in CN, an oversight that can upend the insights gained thus far. Here, using a comprehensive global CN analysis on drought onsets, we show that oceanic regions harbor significantly larger drought hubs than land regions. The Indo-Pacific Warm pool (IPWP) in the Maritime continent emerges as the most significant drought hub having the farthest teleconnections. We show that IPWP, together with a few sub-tropical land and ocean regions, exhibit a ‘rich club phenomenon’ in CN. Further, using a causal network learning algorithm, we demonstrate the confounding role of oceans in modulating drought onsets on land regions. Our study reveals insights on the spatiotemporal linkages of global drought onsets and highlights the role of oceans in driving global drought teleconnections and modulation of land drought hubs.
Open and reusable deep learning for pathology with WSInfer and QuPath
Authors: Kaczmarzyk Jakub R. , O’Callaghan Alan , Inglis Fiona , Gat Swarad , Kurc Tahsin , Gupta Rajarsi , Bremer Erich , Bankhead Peter , Saltz Joel H. 
Published: January 2024

AbstractDigital pathology has seen a proliferation of deep learning models in recent years, but many models are not readily reusable. To address this challenge, we developed WSInfer: an open-source software ecosystem designed to streamline the sharing and reuse of deep learning models for digital pathology. The increased access to trained models can augment research on the diagnostic, prognostic, and predictive capabilities of digital pathology.
Raman scattering excitation in monolayers of semiconducting transition metal dichalcogenides
Authors: Zinkiewicz M. , Grzeszczyk M. , Kazimierczuk T. , Bartos M. , Nogajewski K. , Pacuski W. , Watanabe K. , Taniguchi T. , Wysmołek A. , Kossacki P. , Potemski M. , Babiński A. , Molas M. R. 
Published: January 2024

AbstractRaman scattering excitation (RSE) is an experimental technique in which the spectrum is made up by sweeping the excitation energy when the detection energy is fixed. We study the low-temperature (T = 5 K) RSE spectra measured on four high quality monolayers (ML) of semiconducting transition metal dichalcogenides (S-TMDs), i.e. MoS2, MoSe2, WS2, and WSe2, encapsulated in hexagonal BN. The outgoing resonant conditions of Raman scattering reveal an extraordinary intensity enhancement of the phonon modes, which results in extremely rich RSE spectra. The obtained spectra are composed not only of Raman-active peaks, i.e. in-plane E$${}^{{\prime} }$$

′

and out-of-plane A$${}_{1}^{{\prime} }$$

1

′

, but the appearance of 1st, 2nd, and higher-order phonon modes is recognized. The intensity profiles of the A$${}_{1}^{{\prime} }$$

1

′

modes in the investigated MLs resemble the emissions due to neutral excitons measured in the corresponding PL spectra for the outgoing type of resonant Raman scattering conditions. Furthermore, for the WSe2 ML, the A$${}_{1}^{{\prime} }$$

1

′

mode was observed when the incoming light was in resonance with the neutral exciton line. The strength of the exciton-phonon coupling (EPC) in S-TMD MLs strongly depends on the type of their ground excitonic state, i.e. bright or dark, resulting in different shapes of the RSE spectra. Our results demonstrate that RSE spectroscopy is a powerful technique for studying EPC in S-TMD MLs.
Single-cell sequencing reveals increased LAMB3-positive basal keratinocytes and ZNF90-positive fibroblasts in autologous cultured epithelium
Authors: Lian Weiling , Zeng Xuanhao , Li Jian , Zang Qing , Liu Yating , Lv Haozhen , Chen Shujun , Huang Shiyi , Shen Jiayi , Tang Luyan , Xu Yu , Wu Fuyue , Zhang Qi , Xu Jinhua 
Published: January 2024

AbstractAutologous cultured epithelium grafting (ACEG) presents a promising treatment for refractory vitiligo, yet concerns regarding infections and immunological reactions hinder its surgical use due to serum and feeder dependencies. Addressing this, we culture autologous epithelium under serum- and feeder-free (SFF) conditions, comparing its safety and efficacy with serum- and feeder-dependent (SFD) conditions in stable vitiligo patients, and we discover no significant differences in repigmentation between the SFF and SFD grafts. Single-cell RNA transcriptomics on SFF- and SFD-cultured epithelium alongside healthy skin reveal increased populations of LAMB3+ basal keratinocytes and ZNF90+ fibroblasts in the SFF sheets. Functional analyses showcase active cellular metabolism in LAMB3+ basal keratinocytes, vital in extracellular matrix homeostasis, while ZNF90+ fibroblasts demonstrate increased differentiation, essential in collagen formation for cell adhesion. Importantly, these cell populations in SFF sheets exhibit enhanced interactions with melanocytes compared to SFD sheets. Further, knockdown experiments of LAMB3 in keratinocytes and ZNF90 in fibroblasts lead to a downregulation in melanocyte ligand-receptor-related genes. Overall, SFF sheets demonstrate comparable efficacy to SFD sheets, offering superior safety. LAMB3+ basal keratinocytes and ZNF90+ fibroblasts act as potential drivers behind repigmentation in ACEG under SFF conditions. This study provides translational insights into ACEG repigmentation and potential therapeutic targets for vitiligo.
CCDC88B interacts with RASAL3 and ARHGEF2 and regulates dendritic cell function in neuroinflammation and colitis
Authors: Olivier Jean-Frederic , Langlais David , Jeyakumar Thiviya , Polyak Maria J. , Galarneau Luc , Cayrol Romain , Jiang Hua , Molloy Kelly R. , Xu Guoyue , Suzuki Harumi , LaCava John , Gros Philippe , Fodil Nassima 
Published: January 2024

AbstractCCDC88B is a risk factor for several chronic inflammatory diseases in humans and its inactivation causes a migratory defect in DCs in mice. CCDC88B belongs to a family of cytoskeleton-associated scaffold proteins that feature protein:protein interaction domains. Here, we identified the Rho/Rac Guanine Nucleotide Exchange Factor 2 (ARHGEF2) and the RAS Protein Activator Like 3 (RASAL3) as CCDC88B physical and functional interactors. Mice defective in Arhgef2 or Rasal3 show dampened neuroinflammation, and display altered cellular response and susceptibility to colitis; ARHGEF2 maps to a human Chromosome 1 locus associated with susceptibility to IBD. Arhgef2 and Rasal3 mutant DCs show altered migration and motility in vitro, causing either reduced (Arhgef2) or enhanced (Rasal3) migratory properties. The CCDC88B/RASAL3/ARHGEF2 complex appears to regulate DCs migration by modulating activation of RHOA, with ARHGEF2 and RASAL3 acting in opposite regulatory fashions, providing a molecular mechanism for the involvement of these proteins in DCs immune functions.
The serine synthesis pathway drives osteoclast differentiation through epigenetic regulation of NFATc1 expression
Authors: Stegen Steve , Moermans Karen , Stockmans Ingrid , Thienpont Bernard , Carmeliet Geert 
Published: January 2024

AbstractBone-resorbing osteoclasts are vital for postnatal bone health, as increased differentiation or activity results in skeletal pathologies such as osteoporosis. The metabolism of mature osteoclasts differs from their progenitor cells, but whether the observed metabolic changes are secondary to the altered cell state or actively drive the process of cell differentiation is unknown. Here, we show that transient activation of the serine synthesis pathway (SSP) is essential for osteoclastogenesis, as deletion of the rate-limiting enzyme phosphoglycerate dehydrogenase in osteoclast progenitors impairs their differentiation and results in increased bone mass. In addition, pharmacological phosphoglycerate dehydrogenase inhibition abrogated bone loss in a mouse model of postmenopausal osteoporosis by blocking bone resorption. Mechanistically, SSP-derived α-ketoglutarate is necessary for histone demethylases that remove repressive histone methylation marks at the nuclear factor of activated T cells, cytoplasmic 1 (Nfatc1) gene locus, thereby inducing NFATc1 expression and consequent osteoclast maturation. Taken together, this study reveals a metabolic–epigenetic coupling mechanism that directs osteoclast differentiation and suggests that the SSP can be therapeutically targeted to prevent osteoporotic bone loss.
Long-term wetland biomonitoring highlights the differential impact of land use on macroinvertebrate diversity in Dongting Lake in China
Authors: Zhang Yan , Huang Daizhong , Jin Xiaowei , Li Liqiang , Wang Chouming , Wang Yeyao , Pellissier Loïc , Johnson Andrew C. , Wu Fengchang , Zhang Xiaowei 
Published: January 2024

AbstractFreshwater wetlands have experienced disproportionate biodiversity loss due to environmental change. The lack of long-term biological data limits our understanding of wetland biodiversity dynamics and principal drivers. Here, we combine aquatic biomonitoring with satellite-derived imagery and spatial-explicit analysis to assess the changes in macroinvertebrate diversity and driving factors from 1988 to 2017 in Dongting Lake, China. The results revealed declining macroinvertebrate alpha diversity (species richness and functional redundancy) but increased beta diversity (taxonomic and functional dissimilarity). An increase in nutrients due to changes in land-use intensity in the surrounding terrestrial ecosystem was the primary mechanism for the losses of species and functional groups. Alpha diversity changes were most influenced by land-use changes in adjacent land areas 1.5 kilometers from the sampling sites, while beta diversity was affected within 50 meters. Our results highlight a need for attenuating land-use effects by establishing protected buffer areas to protect biodiversity in the future.
Effects of stress on pain in females using a mobile health app in the Russia-Ukraine conflict
Authors: Kazlou Aliaksandr , Bornukova Kateryna , Wickham Aidan , Slaykovskiy Vladimir , Peven Kimberly , Klepchukova Anna , Ponzo Sonia , Garfinkel Sarah 
Published: January 2024

AbstractThe chronic and acute effects of stress can have divergent effects on health; long-term effects are associated with detrimental physical and mental health sequelae, while acute effects may be advantageous in the short-term. Stress-induced analgesia, the attenuation of pain perception due to stress, is a well-known phenomenon that has yet to be systematically investigated under ecological conditions. Using Flo, a women’s health and wellbeing app and menstrual cycle tracker, with a world-wide monthly active usership of more than 57 million, women in Ukraine were monitored for their reporting of stress, pain and affective symptoms before, and immediately after, the onset of the Russian-Ukrainian conflict. To avoid potential selection (attrition) or collider bias, we rely on a sample of 87,315 users who were actively logging multiple symptoms before and after the start of the war. We found an inverse relationship between stress and pain, whereby higher reports of stress predicted lower rates of pain. Stress did not influence any other physiological symptoms with a similar magnitude, nor did any other symptom have a similar effect on pain. This relationship generally decreased in magnitude in countries neighbouring and surrounding Ukraine, with Ukraine serving as the epicentre. These findings help characterise the relationship between stress and health in a real-world setting.
Effect of chain architecture and comonomer ratio on the biodegradability and thermal stability of biodegradable copolymers of l-lactide and δ-valerolactone
Authors: Nanthananon Phornwalan , Kwon Yong Ku 
Published: January 2024

Novel biodegradable copolymers of ʟ-lactide (LA) and δ-valerolactone (VL) were bulk polymerized using stannous octoate as a catalyst initiated with salicylic acid or benzyl alcohol via ring-expansion or ring-opening polymerization, respectively.
Variability in Receptive Language Development Following Bilateral Cochlear Implantation
Authors: Illg Angelika , Adams Doris , Lesinski-Schiedat Anke , Lenarz Thomas , Kral Andrej 
Published: January 2024

Objectives:
The primary aim was to investigate the variability in language development in children aged 5–7.5 years after bilateral cochlear implantation (CI) up to the age of 2 years, and any impact of the age at implantation and additional noncognitive or anatomical disorders at implantation.

Design:
Data of 84 congenitally deaf children that had received simultaneous bilateral CI at the age of ≤ 24 months were included in this retrospective study. The results of language comprehension acquisition were evaluated using a standardized German language acquisition test for normal hearing preschoolers and first graders. Data on speech perception of monosyllables and sentences in quiet and noise were added.

Results:

In a monosyllabic test, the children achieved a median performance of 75.0 ± 12.88%. In the sentence test in quiet, the median performance was 89 ± 12.69%, but dropped to 54 ± 18.92% in noise. A simple analysis showed a significant main effect of age at implantation on monosyllabic word comprehension (
p
< .001), but no significant effect of comorbidities that lacked cognitive effects (
p
= .24). Language acquisition values correspond to the normal range of children with normal hearing. Approximately 25% of the variability in the language acquisition tests is due to the outcome of the monosyllabic speech perception test.

Conclusions:
Congenitally deaf children who were fitted bilaterally in the 1st year of life can develop age-appropriate language skills by the time they start school. The high variability in the data is partly due to the age of implantation, but additional factors such as cognitive factors (e.g., working memory) are likely to influence the variability.
Variation of air condition parameters, in the conditions of the presence of carbon dioxide, in the duct of ventilation installations
Authors: Cămărășescu Alexandru , Drăgoescu Răzvan 
Published: January 2024

Industrial ventilation takes into account the quality of the air inside the IAQ (Indoor Air Quality) and the degree of exposure of workers. In industrial targets the emission regime of contaminants can be 10–100 times higher than in non-industrial targets, but for many pollutants the IAQ levels can be the same.
The parameters of the state of the air which are of interest for the technique of ventilation and air conditioning are: air temperature and humidity, atmospheric pressure and air speed. For the study on the variation of the air state parameters inside the industrial ventilation installations, in the experiment laboratory, on the study of the industrial ventilation systems, the experiment was performed on the variation of the air state parameters in the conditions of circulation through the ventilation duct. an amount of carbon dioxide.
Prior to the introduction of carbon dioxide into the duct, the ventilation system was started, at nominal parameters. During the experiment, the operating parameters of the drive motor were changed using a frequency converter on levels 50; 40; 30; 20; 10 and 5 Hz. The ventilation system used was structured by means of flow converters which were fixed in the open position. The ventilation system as well as the flow variators were operated by the SCADA type command and control system
The paper will present the analysis of the variation of state parameters (temperature, humidity, absolute pressure and air speed) by introducing a constant amount of carbon dioxide in the ventilation duct.
Establishing the necessary measures for carrying out the activity in security conditions during the execution of work on the Iernut - Chetani highway alignment, Mures county
Authors: Matei Adrian , Chiuzan Emeric 
Published: January 2024

The purpose of this work is to establish the regime of methane releases (explosive gas) following the execution of the underpass works of the Sibiu-Pitesti highway in the Curtea de Argeș-Pitesti sector.
INSEMEX Petroșani executed during the period 01-04.11.2022 on-site measurements at four highway underpasses with a total length of 843m as well as in the areas adjacent to these underpasses, noting that these underpasses are from wells in operation and are connected to the SRM Merișani Station. Based on the measurements and observations made, the analysis of the elements taken into study, as well as the existing records and documentation, INSEMEX Petroșani made the present work.
Safety and compatibility requirements for types of protection to explosion applied to electrical equipment intended for use in potentially explosive atmospheres
Authors: Csaszar Tiberiu , Grecea Danut , Beldiman Alexandru , Munteanu Laurentiu 
Published: January 2024

The principles of protection for electrical equipment against the ignition of a potentially explosive atmosphere differ from one type of equipment to another and they can be combined, but only if the principles clearly defined in the literature are respected. There are situations where two or more principles of protection applied to the same equipment are not compatible with each other in order to ensure a level of protection appropriate to the classification of the area endangered by the presence of a potentially explosive atmosphere. In this case, an appropriate selection of technical solutions is required to ensure the explosion protection requirements for designated equipment.
This paper is intended to be a synthesis of the requirements imposed by the technical standards in the specific field of potentially explosive atmospheres - ATEX, as well as highlighting some situations of incorrect application of the types of explosion protection chosen, during commissioning, but also during the exploitation of equipment in installations operating in areas endangered by the presence of potentially explosive atmospheres.