bluuebunny/crossref_metadata_2025_split huggingface dataset:
Early detection of rheumatoid arthritis through patient empowerment by tailored digital monitoring and education: a feasibility study
Authors: Pfeuffer Nicola , Hartmann Fabian , Grahammer Manuel , Simon David , Schuster Louis , Kuhn Sebastian , Krönke Gerhard , Schett Georg , Knitza Johannes , Kleyer Arnd 
Published: February 2025

Abstract
Patients at risk for rheumatoid arthritis (RA) describe fluctuating and nonspecific symptoms, making it difficult to quantify symptom burden and recognize RA progression. This study aimed to assess feasibility and diagnostic value of a multimodal digital self-monitoring program in preclinical RA. This prospective cohort study included individuals at-risk for RA, who first watched self-produced educational videos about (preclinical) RA and joint self-examination techniques and then started the REMOTRA symptom monitoring. Key outcomes measured included patient acceptance (Net Promoter Score: NPS), monitoring program usability (System usability scale: SUS), monitoring adherence, diagnostic accuracy, and reported symptom burden. A total of 43 participants (65.9% female, mean age 50.1 years) were enrolled. The educational and self-examination videos received NPS ratings of 54.4 and 31.6, respectively. The monitoring software received usability scores of 88.1/100 (SD: 5.5) at three months and 85.4/100 (SD: 16.0) at 6 months. 24/41 (58.5%) completed all questionnaires, and the average app usage was 4.8 months (SD: 1.8). None of the patients with a REMOTRA score below 10 developed RA, yielding a negative predictive value and sensitivity of 100%. However, the positive predictive value was 12%, and the specificity was 42.1%. Analgesic and cortisone usage was reported by 58.5% and 29.3% of participants, respectively. The strong patient acceptance, ease of use, and high adherence rates, combined with encouraging diagnostic outcomes, underscore the potential of this personalized digital monitoring and education approach. These findings suggest that further validation through multicenter studies is warranted.
Biases in annual density banding with implications for high-resolution growth chronologies in the massive starlet coral (Siderastrea siderea)
Authors: Zoppe Simon Felix , Knebel Oliver , Diers Diana , Deveaux Michael , Gischler Eberhard 
Published: February 2025

Abstract
The aragonitic skeletons of massive corals (Scleractinia) are commonly used as biological and paleoenvironmental archives based on their annual density banding. In case of high-resolution proxy studies, however, taxon-specific biases related to the skeletal architecture of the selected coral species can occur, which may impact the resulting skeletal growth chronologies. This study focusses on the quantification of high-resolution skeletal density records in the massive starlet coral Siderastrea siderea from a nearshore reef environment at the southern coast of Belize (western Caribbean Sea) by using two-dimensional grid-scanning americium-241 (241Am) gamma densitometry. Multiple linear sample pathways were systematically selected through central corallite areas (i.e., around the columella) and the corresponding walls (synapticulotheca) of contemporaneously formed corallites in S. siderea. By following this approach, annual density banding (or distortions in its formation) can be identified and related to the general architectural elements and/or to variations in the longitudinal alignment of corallites. The demarcation of high-density bands is often more clearly developed in the corallite walls than around the columella. Therefore, future high-resolution linear skeletal density chronologies should be established based on the more robust corallite walls to reduce such biases in density banding of S. siderea corals.
Biomimetic separations in chemistry and life sciences
Authors: Tsopelas Fotios , Stergiopoulos Chrysanthos , Danias Panagiotis , Tsantili-Kakoulidou Anna 
Published: February 2025

Abstract
Since Otto Schmitt introduced the term “biomimetics” in 1957, the imitation of biological systems to develop separation methods and simulate biological processes has seen continuous growth, particularly over the past five decades. The biomimetic approach relies on the use of specific ligands—biospecific, biomimetic, or synthetic—which target biomolecules, such as proteins, antibodies, nucleic acids, enzymes, drugs, pesticides, and other bioactive analytes. This review highlights advances in biomimetic separations, focusing on biomimetic liquid chromatography (including immobilized artificial membrane chromatography, cell membrane chromatography, biomimetic affinity chromatography, weak affinity chromatography, micellar liquid chromatography, immobilized liposome chromatography, and liposome electrokinetic capillary chromatography) for the complex separation and purification of biomolecules and other important chemical compounds. It also explores their application in studying drug-receptor interactions, screening chemical permeability, absorption, distribution, toxicity, as well as predicting environmental risks. Additionally, this review discusses the application of biomimetic magnetic nanoparticles, which leverage biological membranes and proteins for drug discovery, protein purification, and diagnostics.

Graphical Abstract
SkillAR: omnipresent in-situ feedback for motor skill training using AR
Authors: Diller Florian , Henkel Nico , Scheuermann Gerik , Wiebel Alexander 
Published: February 2025

Abstract
We present a novel technique called SkillAR to display augmented reality feedback for motor skill learning on a head-mounted display (HMD). SkillAR allows the user to consider movement corrections independent of the head position. Therefore, the user can receive motor feedback comfortably without risking an incorrect exercise performance. Head-mounted displays represent versatile technologies for providing motor feedback regarding skill training. In contrast to room-mounted displays, HMDs are easily portable and wearable. That allows for in-situ feedback in many situations where this would otherwise not be possible. However, the spatial positioning of the 3D feedback is not trivial. On the one hand, the user needs to understand the relation between the body and the suggested corrections in the space. On the other hand, certain exercises demand a specific head positioning to minimize errors and injuries. Depending on the exercise and the type of feedback, these two aspects can be highly conflicting. The paper at hand presents a solution for augmented reality headsets, that provides continuous and omnipresent motor feedback comfortably while facilitating a correct exercise performance. In an in-subject user study with 39 participants, we could not detect a significant disadvantage to SkillAR compared to conventional feedback methods found in the literature regarding identification and execution time as well as identification accuracy, in addition to the apparent major advantages for user health and usability. Furthermore, we found that the users could identify the feedback on the HMD more accurately.
Describing How a Medical Career Impacts Physicians’ Couple Relationships: A Qualitative Content Analysis Exploring the Experiences of U.S. Physicians, Physicians-in-Training, and Their Partners
Authors: Wagner Kathryn , Pickens Jaclyn Cravens , Brown Cameron , Soloski Kristy 
Published: February 2025

Abstract
Those who enter the medical field are required to work extensive hours, invest significant money on their education, and can experience multiple relocations through different levels of training. The demands of a career in medicine may create work-to-family conflict that could lead to physicians and their partners seeking services for mental health concerns and/or relationship dissatisfaction. Systemically trained therapists are well suited to understand how the high career demands of the medical field influence the support systems of physicians, as well as advocate for third order change in educational and/or training systems that physicians are in to support the next generations of physicians. The purpose of this study was to highlight the unique experiences of those in physician relationships to understand how the work demands of a career in medicine impact their relationships. Data were collected from survey responses of individual participants (n = 35) who are in a physician relationship lasting at least 6 months and included both medical and non-medical partners. Results revealed five themes and 17 subthemes which highlight the unique experiences of those in physician relationships. Results identify aspects of physician relationships that mental health clinicians can use to guide therapeutic work with these clients in couple’s therapy. Future research and clinical implications are discussed.
Measuring Early Maladaptive Schemas in Daily Life
Authors: Baxendell Robbert S. , Schmitter Michèle , Spijker Jan , Keijsers Ger P. J. , Tendolkar Indira , Vrijsen Janna N. 
Published: February 2025

Abstract

Background
The theoretical models of Beck and Young predict that Early Maladaptive Schemas (EMSs) are linked to the development and maintenance of mental health problems including depression. The stability of EMSs in daily life are ill-understood despite being a fundamental aspect of cognitive theories. In the current study, we aimed to improve the understanding of EMSs by repeatedly assessing them in daily life under changing contextual triggers and examining the theoretically-grounded associations with mood and rumination.

Methods
Using factor analysis, we developed a 16-item Ecological Momentary Assessment (EMA) version of the Dutch Young Schema Questionnaire short form (Klynstra et al., 2008). EMSs were assessed six times a day for five days in 90 unselected participants (71% female, Mage = 25.52).

Results
The new EMA-based EMSs questionnaire captured EMSs fluctuations, with 51% of the variance attributed to within-person variations. We assessed the contemporaneous within-person associations between schema activation and negative affect and rumination as well as the impact of a triggering event on schema activation. Stronger EMSs activation was associated with more negative mood and rumination, as well as the occurrence of a recent triggering event.

Conclusions
The findings align with the cognitive models of Beck and Young extending them with daily life data. The results indicate that EMSs have both state and trait-like characteristics, and fluctuations in daily life can be assessed.
Investigating the Connectedness between Oil and Stock Markets in GCC countries: Evidence from Rolling-Window Frequency Domain Causality
Authors: Sezen Serhat , Cevik Emrah I. , Al-Eisa Eisa Abdulrahman , Bugan Mehmet Fatih , Destek Mehmet Akif 
Published: February 2025

Abstract
This study aims to investigate the causal relationship between oil prices and stock markets in GCC countries. We use weekly stock index and crude oil price data from November 21, 2003, to August 6, 2021, to analyze the spillover effect on the returns and variances of these countries. First, the link between the variables is examined using the frequency domain causality test. Since our sample includes important financial episodes such as the global financial crisis and the global COVID-19 pandemic, we employ rolling-window frequency domain causality test to determine whether such causal relationships exist in these financial crises. To the best of our knowledge, the paper is among the first to employ rolling-window frequency domain causality test to investigate the relationship between the variables. The analysis reveals that the Omani, Kuwaiti, and Bahraini stock markets have limited portfolio diversification benefits due to their high dependence on the price of oil. In addition, Saudi Arabia has the most pronounced divergence in the oil price interaction among GCC stock markets. Investors can benefit from the empirical results practical implications, particularly regarding portfolio diversification. The shifting link between oil and stock markets across different countries and time periods underscores the importance of dynamic diversification strategies that adapt to business cycles.
Occurrence of mobulid rays in Northwest Madagascar
Authors: Diamant Stella , Bosio Caterina , Rambahiniarison Joshua , Scarffe Chris , Strogoff Michel , Kiszka Jeremy J. , Bennett Rhett , d’Echon Tanguy Guillemain , Sourisseau Elina , Fidiarisandratra Léonce C. M. , Cerchio Salvatore , Venables Stephanie , Flam Anna , Andrianarisoa Fanja Ratsitoharana , Barba Carlotta , Rasoamananto Irène , Pierce Simon J. 
Published: February 2025

Abstract
The waters around Nosy Be in northwest Madagascar are well-known for the occurrence of large planktivores, such as whale sharks (Rhincodon typus) and Omura’s whales (Balaenoptera omurai). Between 2016 and 2022, sighting data on mobulid rays were opportunistically collected during tourism activities. Additional sources, including citizen science submissions, tourism operator reports, and social media records, were used to compile sightings of three mobulid ray species. A total of 255 encounters were documented, with Mobula mobular (n = 165) being the most common, followed by M. birostris (n = 60) and M. kuhlii (n = 30). Notably, the absence of confirmed M. alfredi records since 2015 suggests a potential local decline. This study highlights Nosy Be as a habitat for mobulid rays and emphasises the necessity for further species monitoring, ongoing identification of potential threats, and management initiatives aiming at reducing mortality from gillnet fishing.
Feasibility and Acceptability of Formats in a Comparative Effectiveness Trial of a Preventive Parenting Program
Authors: Buchanan Gretchen , Simenec Tori , Cai Qiyue , Gewirtz Abigail 
Published: February 2025

Abstract
Parenting can be challenging, and military parents face additional family stressors related to relocations and deployments. ADAPT4U is an evidence-based preventive parenting program specifically designed for military parents of school-aged children. This study examines the feasibility and acceptability of in-person group and telehealth versions of the program. We used quantitative and qualitative data in a concurrent embedded design. Quantitative data were analyzed using SPSS with regressions and ANOVAs. Qualitative data were thematically coded by multiple authors and then a consensus process was undertaken. Both conditions were highly satisfactory for participants, with in-person group rated slightly higher. Families were more likely to attend telehealth than group, both at all and for at least 50% of sessions. Telehealth participants rated more highly: helpfulness, the facilitator was understanding and responsive, and they would participate in a future parenting program based on their experience. Qualitative results reflected positive experiences both with the content and facilitators, and concerns or recommendations that often were directly addressed by the other format (e.g., suggestions by in-person group participants for a telehealth format). Consistent themes across formats included wanting children to be involved in the program and more follow-up after the end of the program. The ADAPT4U program is highly acceptable to participants, and providing multiple format options (in-person group and individual telehealth) will likely make it more feasible for parents to participate in a way that works best for them.
Modified Patankar Linear Multistep Methods for Production-Destruction Systems
Authors: Izzo Giuseppe , Messina Eleonora , Pezzella Mario , Vecchio Antonia 
Published: February 2025

Abstract
Modified Patankar schemes are linearly implicit time integration methods designed to be unconditionally positive and conservative. In the present work we extend the Patankar-type approach to linear multistep methods and prove that the resulting discretizations retain, with no restrictions on the step size, the positivity of the solution and the linear invariant of the continuous-time system. Moreover, we provide results on arbitrarily high order of convergence and we introduce an embedding technique for the Patankar weights denominators to achieve it.
Analysis of Robust Hybridized Discontinuous Galerkin Methods for Viscoacoustic Wave Equations
Authors: Lee Jeonghun J. , Ruiz Bolanos Jesus Indalecio 
Published: February 2025

Abstract
In this paper we study hybridized discontinuous Galerkin methods for viscoacoustic wave equations with a general number of viscosity terms. For viscoacoustic equations rewritten as a first order symmetric hyperbolic system, we develop a hybridized local discontinuous Galerkin method which is robust for the number of viscosity terms. We show that the method satisfies a discrete energy estimate such that the implicit constants in the energy estimate are independent of the number of viscosity terms and the length of simulation time. Furthermore, we show that the sizes of reduced system after static condensation are independent of the number of viscosity terms. Optimal a priori error estimates with the Crank–Nicolson scheme are proved and numerical test results are included.
Optimized cement blend for the immobilization of simulated borate radioactive liquid waste
Authors: Iklaga Gabriel , Rostamiparsa Mojtaba , Tolnai István , Kaposy Nándor , Gméling Katalin , Csipa Emese , Tóbi Csaba , Gável Viktória , Kónya Péter , Szabó Csaba , Fábián Margit , Szabó-Krausz Zsuzsanna , Völgyesi Péter 
Published: February 2025

Abstract
Nuclear power plants use boric acid with different 10B enrichment levels (from natural ratio to 90% 10B) as neutron absorber and at the end this constitutes a high-volume liquid waste. In this study, we aimed to find the optimal ratio of Portland cement and sulfoaluminate cement blend to improve the mechanical and chemical durability of final waste forms for borate immobilization. The standardized ASTM C1308-21 leaching test experimental method in combination with several analytical methods i.e. mechanical test, SEM, XRD, PGAA, ICP-OES, and ICP-MS were used to measure the boron elemental and isotopic leachability and its microstructural effect on the cement hydration characteristics of progressively increasing blend ratios of sulfoaluminate cement in Portland cement. The results indicated that the blend ratio of 20% sulfoaluminate cement to 80% Portland cement showed the best physical stability and lowest boron isotopic leachability from the final waste form.
Yin Yang 1: Function, Mechanisms, and Glia
Authors: Rodríguez-Campuzano Ada G. , Castelán Francisco , Hernández-Kelly Luisa C. , Felder-Schmittbuhl Marie-Paule , Ortega Arturo 
Published: February 2025

Abstract
Yin Yang 1 is a ubiquitously expressed transcription factor that has been extensively studied given its particular dual transcriptional regulation. Yin Yang 1 is involved in various cellular processes like cell cycle progression, cell differentiation, DNA repair, cell survival and apoptosis among others. Its malfunction or alteration leads to disease and even to malignant transformation. This transcription factor is essential for the proper central nervous system development and function. The activity of Yin Yang 1 depends on its interacting partners, promoter environment and chromatin structure, however, its mechanistic activity is not completely understood. In this review, we briefly discuss the Yin Yang 1 structure, post-translational modifications, interactions, mechanistic functions and its participation in neurodevelopment. We also discuss its expression and critical involvement in the physiology and physiopathology of glial cells, summarizing the contribution of Yin Yang 1 on different aspects of cellular function.
Valorization of C2 + Hydrocarbons Via Plasma Processes
Authors: Cameli Fabio , Stefanidis Georgios D. 
Published: February 2025

Abstract
Hydrocarbon chains produced as byproduct of natural gas extraction and petrochemical processing can be valorised into syngas/H2 and oxygenated fuels in a modular fashion through electrified modular plasma reactors. A plethora of configurations is available for light hydrocarbons reforming, with cold plasma assemblies emerging as the favourite option for both gas-phase and biphasic gas/liquid set-ups. Accurate control of dehydrogenation or partial oxidation reactions is provided by the implementation of a catalyst or through microreactor technology. On the contrary, warm plasma reactors are more suitable for reforming of gasoline/diesel chains, promoting higher throughput of H2 per energy input. This reaction route does not necessarily require the deployment of a catalyst, hence making these systems more suitable for modular, decentralized processes. Online diagnostic techniques shed light on the reaction mechanism, where solid carbon deposits embody a low-value byproduct.
It’s About Time: Parent’s Direct Care for Children in Hispanic Noncitizen Households Across State Immigration Policy Contexts
Authors: Pedroza Juan Manuel , Losada Elena 
Published: February 2025

Abstract
Is parent’s direct care for children more common in state contexts with inclusive policies toward immigrants? If so, among whom do we find such a relationship? We analyze American Time Use Survey (ATUS) data between 2010 and 2019 to investigate whether daily routines involving parent’s direct care for children (e.g., playtime, sports, reading, etc.) vary with different immigration policy contexts. Among parents responding to the ATUS, we find that Hispanic parents in Hispanic noncitizen households are more likely to report having engaged in direct care for their children if they live in states with more inclusive policies toward immigrants. No comparable results apply to households with no Hispanic noncitizens, including non-Hispanic parents (White, Black, or Asian) or Hispanic citizen parents in U.S. citizen households. Our work identifies a possible route to increase the pool of parents engaging in direct care: recent state policies designed to integrate immigrants. Providing Hispanic noncitizen households with a combination of resources and support may help promote direct care for children, including time devoted to children’s developmental care.
Effective integration and models of information: lessons from integrative structure modeling
Authors: Bolinska Agnes , Sali Andrej 
Published: February 2025

Abstract
Integrative structure modeling is a method for using information from multiple sources to compute structural models of biomolecular systems. It proceeds via four steps: (i) defining the model representation, which determines the variables whose values will be computed; (ii) constructing a function for scoring alternative models according to how well they accommodate input information; (iii) searching a space of candidate models for acceptable models; and (iv) analyzing acceptable models to evaluate their fit with input information. These steps are iterated until a model adequate for addressing biological questions is found. In this paper, we draw lessons from integrative modeling about effective integration and about modeling. We describe what it means to integrate information from multiple sources: Integration amounts to distributing information among the four steps of integrative modeling. Theory and data alike can be sources of information; this process thus generates models of information, rather than models of theory or models of data. We then propose heuristics for distributing information and designing multiple iterations of modeling. Effective iteration requires prioritizing the most reliable information and minimizing the time required to obtain an adequate model. Rather than being constructed from theory and assessed using data, models are constructed from any available information and assessed in a coherentist manner.