bluuebunny/crossref_metadata_2025_split huggingface dataset:
Regionalized estimates of enteric methane emissions from cattle raised in Italian territory
Authors: Notarnicola B , Spizzirri U G , Renzulli P A , Astuto F , Di Capua R , De Molfetta M , Fosco D 
Published: December 2023

Abstract
Within the framework of the Extended Partnership "Economic-Financial Sustainability of Systems and Territories" (GRINS Project Spoke 1, WP3), this work proposes a regional estimate of the amount of enteric methane produced by cattle raised in the Italian territory. These data will be used to create national and regional datasets that will be an integral part of the AMELIA platform and will be freely available for use by both public and private managers for environmental impact assessments in the livestock sector. To this purpose, the IPCC (level 2) provides statistical models capable of evaluating this parameter, considering population, daily weight gain, animal weight, type of breeding, and dietary intake for each considered breed. In particular, in the calculation of enteric emissions, 37 pure breeds with different attitudes (milk, meat, and dual-purpose) have been considered, whose population is significant (>1%) at the national and/or regional level. For each individual breed, six classes have been considered, considering age and gender of the cattle. In addition, 22 crossbred breeds have been added, 21 specifics to each region and one at the national level. Regional emissions have been estimated by considering the average population of each breed in the period 2019-2022, normalizing the contributions of the individual species in a delimited territory and/or geographic area. In this way, six contributions have been calculated for each Italian region, representing a statistical assessment of the emissions that will subsequently be confirmed in the field through direct measurements using innovative instrumental technologies. Overall, this analysis offers a comprehensive view of how regional factors, and the composition of cattle breeds can impact greenhouse gas emissions. These findings provide valuable guidance for advancing sustainability initiatives within the agricultural sector.
Corneal retardation time as an ocular hypertension disease indicator
Authors: del Barco Oscar , Ávila Francisco J , Marcellán Concepción , Remón Laura 
Published: December 2023

Abstract

Objective. A detailed analysis of the corneal retardation time τ as a highly related parameter to the intraocular pressure (IOP), and its plausible role as an indicator of ocular hypertension disease. Approach. A simple theoretical expression for τ is derived within the corneal viscoelastic model of Kelvin-Voigt with 3 elements. This retardation time can be easily calculated from the well-known signal and pressure amplitudes of non-contact tonometers like the Ocular Response Analyzer (ORA). Then, a population-based study was performed where 100 subjects aged from 18 to 30 were analyzed (within this group, about 10% had an elevated IOP with more than 21 mmHg). Main results. A clear relationship between the corneal retardation time and the corneal-compensated intraocular pressure (IOPcc) was found, underlying the risk for ocular hypertensive (OHT) subjects with lower τ values to develop hypertension illnesses (due to the inability of poorly viscoelastic corneas to absorb IOP fluctuations, resulting in probable optic nerve damage). Significance. Our results might provide an useful tool to systematically discern which OHT patients (and even those with normal IOP values) are more likely to suffer glaucoma progression and, consequently, ensure an early diagnosis.
Evaluating long-term water storage trends in small catchments and aquifers from a joint inversion of 20 years of GRACE/GRACE-FO mission data
Authors: Kvas A , Boergens E , Dobslaw H , Eicker A , Mayer-Guerr T , Güntner A 
Published: December 2023

SUMMARY
More than 20 yr of measurement data of the gravity missions GRACE (Gravity Recovery And Climate Experiment) and GRACE-FO (GRACE-Follow-On) allow detailed investigations of long-term trends in continental terrestrial water storage (TWS). However, the spatial resolution of conventional GRACE/GRACE-FO data products is limited to a few hundred kilometres which restrains from investigating hydrological trends at smaller spatial scales. In this study GRACE and GRACE-FO data have been used to calculate TWS trends with maximized spatial resolution. Conventionally, GRACE/GRACE-FO is presented as a series of either unconstrained gravity fields post-processed with spatial low pass filters or constrained inversions commonly known as Mascon products. This paper demonstrates that both approaches to suppress spatially correlated noise are mathematically equivalent. Moreover, we demonstrate that readily inverting all available sensor data from GRACE/GRACE-FO for a single TWS trend map, together with annual variations and a mean gravity field, provides additional spatial detail not accessible from the standard products. The variable trade-off between spatial and temporal resolution as a unique feature of satellite gravimetry allows for gravity products that are tailored towards specific geophysical applications. We show additional signal content in terms of long-term water storage trends for four dedicated examples (Lake Victoria, Northwest India, Bugachany Reservoir and High Plains Aquifer) for which external information from other remote sensing instruments corroborates the enhanced spatial resolution of the new mean-field trend product.
The Billirud Mill Blastomycosis Outbreak: Comparison to Historical Controls
Authors: Van Howe Robert S 
Published: December 2023

Abstract
A large outbreak of blastomycosis among paper mill workers in Escanaba, Michigan began with the first cases reported on February 28, 2023 and expanded to 120 cases. Analysis of baseline regional data and the data collected during this unprecedented outbreak provide insight on the outbreak's unique characteristics. The Michigan Disease Surveillance System provided descriptive and outcome data on blastomycosis cases in the Upper Peninsula from 2007 through 2022 and the 2023 outbreak. Baseline incidence for the region was estimated and outbreak cases were compared to historic controls using quantitative methods such as t-tests, chi-square, and Poisson and logistic regression. The Billirud blastomycosis outbreak has resulted in 28 confirmed and 92 probable cases. Blastomycosis incidence for the Upper Peninsula was 2.13 (95%CI: 1.75, 2.59) per 100,000 person-years with counties bordering Wisconsin having a higher incidence more than other counties (4.56, 95%CI: 3.48, 5.97; RR=3.46, 95%CI: 2.35, 5.11). Outbreak cases were significantly younger, more likely to be male, reported more respiratory symptoms, and had a shorter time from onset of illness to diagnosis. The Billirud paper mill blastomycosis outbreak is the largest reported to date, the first in an industrial facility, and the first to specifically involve Blastomyces gilchristii. Blastomyces species are endemic in regional forests, so other facilities handling forestry products may be at risk.
Banking on Carbon: Corporate Lending and Cap-and-Trade Policy
Authors: Ivanov Ivan T , Kruttli Mathias S , Watugala Sumudu W 
Published: December 2023

Abstract
We estimate the effect of carbon pricing policy on bank credit to greenhouse-gas-emitting firms. Our analyses exploit the geographic restrictions inherent in California’s cap-and-trade bill and a discontinuity in the embedded free permit threshold of the federal Waxman-Markey cap-and-trade bill. Affected high emission firms face shorter loan maturities, lower access to permanent forms of bank financing, higher interest rates, and higher participation of shadow banks in their lending syndicates. These effects are concentrated among private firms, while credit terms of public firms are largely unaffected. Overall, we show that banks respond quickly to realizations of transition risk.
Using eHealth Data to Inform CPD for Medical Practitioners: A Scoping Review with a Consultation Exercise with International Experts
Authors: Pizzuti Carol , Palmieri Cristiana , Shaw Tim 
Published: December 2023

Introduction:eHealth data analytics is widely used in health care research. However, there is limited knowledge on the role of eHealth data analysis to inform continuing professional development (CPD). The aim of this study was to collate available research evidence on the use of eHealth data for the development of CPD programs and plans for medical practitioners.Methods:A scoping review was conducted using the six-stage Arksey and O'Malley Framework. A consultation exercise (stage 6) was performed with 15 international experts in the fields of learning and practice analytics to deepen the insights.Results:Scoping review.The literature searches identified 9876 articles published from January 2010 to May 2022. After screening and full-text review, a total of nine articles were deemed relevant for inclusion. The results provide varied—and at times partial or diverging—answers to the scoping review research questions.Consultation exercise.Research rigor, field of investigation, and developing the field were the three themes emerged from analysis. Participants validated the scoping review methodology and confirmed its results. Moreover, they provided a meta-analysis of the literature, a description of the current CPD ecosystem, and clear indications of what is and should be next for the field.Discussion:This study shows that there is no formal or well-established correlation between eHealth data and CPD planning and programming. Overall findings fill a gap in the literature and provide a basis for further investigation. More foundational work, multidisciplinary collaborations, and stakeholders' engagement are necessary to advance the use of eHealth data analysis for CPD purposes.
High-Grade Spindle Cell Sarcoma of the Scalp With an MGA::NUTM1 Gene Fusion in a Pediatric Patient
Authors: Arellano Zameza Priscila , Karklins Samantha P. , Pena Joseph , Bowers Nathan L. , Samman Abdulhadi , Ahn Christine , Sangueza Omar P. 
Published: December 2023

Abstract:
NUT carcinoma (NC) is a rare and aggressive neoplasm associated with a poor prognosis. NC is characterized by a NUTM1-rearrangement on chromosome 15q14, commonly fused with the BRD4 or BRD3 gene. A rare subset of NC defined by fusion of NUTM1 with the MGA gene has been identified, showing mesenchymal differentiation on histology. Few cases of spindle cell sarcomas harboring MGA::
NUTM1 gene fusions have been reported in the literature. We describe a case of spindle cell sarcoma harboring an MGA::
NUTM1 fusion in a 6-year-old male patient. In contrast to typical cases of spindle cell carcinomas or NC, NUTM1 fusion-positive sarcomas are associated with a better prognosis. This report highlights the importance of diagnostic workup of undifferentiated neoplasms, as identification of the MGA::
NUTM1 fusion in spindle cell sarcoma could be used in treatment algorithms and lead to better outcomes, to the benefit of patients.
Thyroid Eye Disease: Epidemiology, Natural History, and Risk Factors
Authors: Bartalena Luigi , Gallo Daniela , Tanda Maria Laura , Kahaly George J. 
Published: December 2023

Background:
Thyroid eye disease (TED) is an autoimmune disorder of the orbit and the most frequent extrathyroidal manifestation of Graves’ disease but it may rarely occur in euthyroid/hypothyroid patients with chronic autoimmune thyroiditis.

Epidemiology:
TED is a relatively infrequent disorder, particularly in its severe forms. Men tend to have more severe TED at an older age. The prevalence of TED is lower than in the past among patients with recent onset Graves’ hyperthyroidism, and moderate-to-severe forms requiring aggressive treatments are no more than 5% to 6% of all cases.

Natural history:
After an initial inflammatory (active) phase and a plateau phase, TED stabilizes and eventually inactivates (inactive or burnt-out phase) after an estimated period of 18–24 months. Minimal-to-mild TED often remits spontaneously, but complete restitutio ad integrum almost never occurs when TED is more than mild.

Risk factors:
Several risk factors contribute to its development on a yet undefined genetic background. Cigarette smoking is the most important of them, but thyroid dysfunction (both hyper- and hypothyroidism), radioactive iodine therapy (if not accompanied by low-dose steroid prophylaxis), elevated thyrotropin receptor antibodies, and, probably, hypercholesterolemia represent relevant modifiable risk factors. Early diagnosis, control and removal of modifiable risk factors, and early treatment of mild forms of GO (local treatment and selenium) may effectively limit the risk of progression to more severe forms.
Assessing the contribution of plastic-associated obesogenic compounds to cardiometabolic diseases
Authors: Warger Jacob , Lucas Michaela , Lucas Andrew 
Published: December 2023

Purpose of review
To present recent evidence that strengthens the concept that exogenous pollutants contribute to adipose dysfunction and increased rates of disease and to highlight the ineffective regulation of this risk as industry switches to related but similarly toxic variants.

Recent findings
Substitutes for common phthalates and the highly regulated bisphenol A (BPA) show similar deleterious effects on adipocytes. The well tolerated limit for BPA exposure has been reduced in Europe to below the level detected in recent population studies. Additionally, the role for BPA-induced inflammation mediated by interleukin 17a has been described in animal and human studies.

Summary
Despite experimental and associative evidence that supports plastics and plastic associated chemicals deleteriously influencing adipose homeostatasis and contributing to metabolic diseases, structurally related alternate chemicals are being substituted by manufacturers to circumvent trailing regulatory actions.
Freeing and Stretching the Palatine Vessels From the Greater Palatine Foramen in Palatoplasty
Authors: Hwang Kun , Lee Se Il , Han Seung-Ho 
Published: December 2023

The aim of this paper is to present how to free and stretch the palatine vessels from the greater palatine foramen in palatoplasty. After a mucoperiosteal flap is raised, periosteal elevator is passed behind the palatine vessels to detach the periosteum around the vessels. Then, a blunt right-angle instrument is placed behind the palatine vessels, and the vessels are pulled from the foramen in the superior aspect, slightly forward (63 degrees) and medially (19 degrees) according to the direction to the greater palatine canal (GPC). The nasal mucosa is also released from the hard palate and from the lateral pharyngeal wall. After dividing the palatal aponeurosis and elevating the anterior flap, the first suture is inserted through the nasal layer of the mucosa at the level of the posterior border of the hard palate (A suture). The nasal layer is approximated and sutured. After the closure of the buccal layer, the 2 posterior flaps are joined to the small anterior flap. Finally, A suture is tied. In 60 cases of pushback palatoplasty, the palatine vessels were stretched from the greater palatine foramen. In literatures, the length of GPC is 26.97 mm. Anteroposterior diameter of the upper opening of GPC is 3.88 mm. The angle between the vertical plane and the axis of GPC is 19.09 degrees. The angle between the transverse plane and the axis of GPC is 62.63 degrees. Probably, this information is the values obtained in adults. As a matter of fact, similar values were obtained in our study on this subject.
Strong cascading impacts of micropollutants on planktonic food web in urban river
Authors: Adyari Bob , Zhang Lanping , Nascimento Francisco J.A. , Zhang Yiqing , Cao Meixian , Wang Jianjun , Li Hongjun , Sun Qian , Yu Changping , Hu Anyi 
Published: December 2023

AbstractUrban rivers rely on intricate multitrophic interactions in food webs, which are vital for ecological functions. Human-induced pollutant discharge, notably micropollutants, poses a threat to these interactions. To study the impact of micropollutants on the microbial food web, we sampled downstream areas of the Jiulong River’s north tributary (lower urbanization, ∼25% built land) and west tributary (higher urbanization, ∼65% built land) for eleven consecutive days in both dry and wet seasons in Fujian, China. We constructed a conceptualized planktonic food web model by employing DNA metabarcoding targeting bacteria, micro-eukaryotes (algae and protozoa), and microzooplankton. Our results revealed that the more urbanized west tributary exhibited significantly higher micropollutant concentrations. Structural equation modeling (SEM) incorporating micropollutants and all food web elements indicated a significantly stronger impact of micropollutants on the planktonic food web in the west tributary than in the north tributary. Micropollutants exhibited both direct and indirect (cascade) effects on high trophic levels (protozoa and microzooplankton), with algal communities mediating the cascade effects instead of bacterial communities, likely due to the increased eutrophication in the urbanized tributary. Overall, our study underscores the potential ecological disruptions caused by micropollutants in shaping planktonic food web interactions in urban rivers.SynopsisUrban rivers face ecological threats from micropollutants. This study shows elevated micropollutants significantly affected the planktonic food webs. Algal, rather than bacterial, food web pathway mediated micropollutants cascading effects on high trophic levels, emphasizing micropollutant-induced disruptions in urban rivers.
Identification and Analysis of SARS-CoV-2 Mutation and Subtype using 2x tiled Primer Set with Oxford Nanopore Technologies Sequencing for Enhanced Variant Detection and Surveillance in Seoul, Korea
Authors: Han Giyoun , Lee Sojung , Kwon YaeEun , Lyu Jaemyun , Kim Hyunsoo , Yoon Kang-Jun , Kim Minlee 
Published: December 2023

AbstractSevere acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is a respiratory virus that contains RNA as its genetic material and has caused a global pandemic since its outbreak in 2020. This virus has many mutations, some of which can reduce the effectiveness of existing vaccines. Therefore, next-generation sequencing (NGS) is necessary to accurately identify new mutations. Current NGS analysis of SARS-CoV-2 uses the amplicon analysis method through a multiplex polymerase chain reaction. This study collected and validated RNA samples from patients who tested positive for SARS-CoV-2 from April to July 2022, and selected 613 samples for sequencing. The findings demonstrate the importance of long-read-based NGS analysis and 2x tiled primer set for identifying full SARS-CoV-2 genome sequence with new mutations and understanding the correlation between viral genotypes and patient characteristics for the effective management of SARS-CoV-2.
Liver discard rate due to conservative estimations of steatosis: an inference-based approach
Authors: Guo Hao , Gala-Lopez Boris L. , Alwayn Ian P.J. , Hewitt Kevin C. 
Published: December 2023

AbstractBackgroundOn-site conservative estimations of steatosis could result in the unnecessary discard of donor livers. This study applied the body mass index (BMI) as an independent statistical indicator to determine the extent of this problem. We explored two hypotheses: (I) that because of varying levels of expertise and protocols (reputational risk for pathologists), biopsies at transplant centers overestimate hepatic steatosis (HS), and (ii) that non-biopsy donor liver assessments are more conservative than biopsy-based evaluations.MethodsThe study processed cross-database and intra-database comparisons using data from the National Health and Nutrition Examination Survey (NHANES) and Organ Procurement and Transplantation Network (OPTN) spanning January 2017 to March 2020 in the United States. Post-matching BMI was applied as an independent indicator of statistical risk of HS.ResultsContrary to our first hypothesis, biopsies at transplant centers didnotoverestimate HS - biopsy-classified donor livers were found in similar or lower risk categories.Consistent with our second hypothesis, absent biopsies, evaluations before and during organ procurementwereobserved to be more conservative, leading to the discard of 11.9% (373) of potential donor livers.ConclusionsThe study concludes that there was a significant (11.9%) disparity caused by on-site non-biopsy assessments of HS, leading to the unnecessary discard of potential donor livers. The findings emphasize the need to develop more accurate intraoperative techniques for assessing HS to optimize donor liver procurement.
From the third to the seventh generation of selection for muscle fat content in rainbow trout: Consequences for flesh quality
Authors: Lefevre Florence , Bugeon Jérôme , Goardon Lionel , Kerneis Thierry , Labbe Laurent , Panserat Stéphane , Medale Françoise , Quillet Edwige 
Published: December 2023

AbstractMuscle lipid content was shown to affect many quality features in salmonids in both raw and processed fillets. The objective of the present work was to assess the consequences of 7 generations of divergent selection for muscle adiposity on some rainbow trout flesh quality and muscle parameters. Fish from Lean (L) and Fat (F) lines had a similar body weight but L fish were longer and had consequently lower condition factor values. Carcass yield was not affected by selective breeding, but L fish had lower hepato- and gonado-somatic indexes, a bigger head, and lower fillet yield than F fish. A difference of more than 15 points in mean fat-meter®values (genetic selection criteria) was measured between the two lines. Mean muscle lipid content was 5.0±1.0% for L line vs 13.5±2.2% for F line. An absolute difference of more than 6% was measured in fillet dry matter content between the two lines, for raw, cooked, and smoked fillets. Raw fillets from F fish were lighter (L*>) and more colorful (a* and b*>), but softer than those from the L line. Quality parameters of cooked fillets were very similar between the two lines, whereas smoked fillets exhibited, between the two lines, similar differences than raw fillets. A large difference in white muscle fiber size was observed, fish from F line having higher fiber mean diameter, a lower proportion of small fibers, and a higher proportion of large fibers. Sex effects were observed on these immature fish, on classically sex-related traits (GSI and head development), but also on muscle fiber size. Moreover, these effects were more marked in F line. Correlation analysis showed that raw fillet color was positively related to muscle adiposity whereas mechanical resistance was negatively related. Raw fillet mechanical resistance was also negatively correlated to white muscle fiber size. Moreover, smoked fillet quality parameters were correlated to raw fillet ones. The relationships between muscle adiposity, but also muscle cellularity, and fillet quality were discussed.Highlights7 generations of adiposity divergent selection affect raw and smoked fillet quality.Selective breeding led to a noteworthy response in white muscle cellularity.Some differences between male and female was measured in immature pan-size trout.Graphical abstract