bluuebunny/crossref_metadata_2025_split huggingface dataset:
Hydrogel‐Based Macroscopic Click Chemistry
Authors: Li Qingyun , Hu Ziqing , Ji Xiaofan 
Published: November 2023

AbstractThe click reaction has found good utility across various fields due to the characteristics of high efficiency, atom economy, simple and mild reaction conditions. Click chemistry is usually utilized for connecting components of microscopic level, while it is still unable for joining macroscopic building blocks. Materials consisting of macroscopic building blocks realize the flexible fabrication of three‐dimensional structures at macroscopic level, exerting significance on parallel manufactures. In this work, we reported macroscopic click chemistry utilizing hydrogel as macroscopic building blocks. Hydrogels G1 and G2 were prepared by incorporating M1 (N,N′‐dimethyl‐1,2‐ethanediamine) and P1 (alkyne functionalized polyethylene glycol) respectively, where polymer chains formed through diffusion‐induced amino‐yne click reaction entangled different hydrogel networks together. Additionally, chain‐like aggregates and complicated 3D structures such as tetrahedron and quadrangular pyramid were constructed based on the adhesion of the hydrogel blocks. The approach enables us to find more possibilities in the delicate designation of 3D aggregations as well as large‐scale manufacturing.
Furan fatty acid amounts and their occurrence in triacylglycerols of white asparagus (Asparagus officinalis) from the German market
Authors: Müller Franziska , Bauer Vanessa , Vetter Walter 
Published: November 2023

AbstractVegetables including asparagus contain a wide range of fatty acids, mainly stored in triacylglycerols. One class of interesting minor fatty acids is the family of furan fatty acids (FuFAs) because of their antioxidant properties. Since FuFAs have not been studied previously in asparagus (Asparagus officinalis L.), we developed and applied a simplified method for their analysis in 20 fresh and three preserved samples. Four FuFAs were detected with clear dominance of the dimethyl‐substituted FuFAs (D‐FuFAs) 11D5 and 9D5 as well as small amounts of the monomethyl‐substituted FuFAs (M‐FuFAs) 11M5 and 9M5. The total amounts of FuFAs in fresh white asparagus ranged from 1.4 to 4.6 mg/100 g dry weight (mean 3.0 mg/100 g dry weight). Subsequent LC‐Q‐Orbitrap‐HRMS measurements enabled the detection of 22 different FuFA‐containing TAGs. These were predominantly found together with one or two polyunsaturated fatty acid.
Multi‐interactions driven continuous removal of organic dyes from water by lignocellulosic‐based fibers
Authors: Chen Guangyan , Li Chao , Song Dandan , Zhang Yu , Gan Guangdong , Xie Yi , Hu Zai‐Yin 
Published: November 2023

AbstractWater polluted by organic dyes is normally present in industrial production, which seriously threatens environmental safety. Research on dye adsorption has recently been related to nanomaterials due to their large specific surface area. However, there are still some problems associated with their preparation, application, and recovery. In this study, we developed the one‐step synthesis of lignocellulosic‐Fe(OH)3 hybrid fibers by in situ growth of Fe(OH)3 nanoparticles on lignocellulosic, which could be used as effective adsorbents for dye removal. The formed Fe(OH)3 nanoparticles were dispersed homogeneously on the surface of lignocellulosic. The as‐prepared hybrid fibers featured a large absorption capacity for methylene blue, up to 150.9 mg/g. In a fixed‐bed column separation process, dye pollutants were successfully removed from the water even at a high speed of 5.0 mL/min, with the separation efficiency higher than 99.99%. Remarkably, 1.0 g of lignocellulosic‐Fe(OH)3 was capable of separating over 1200 mL of dye solution continuously and thoroughly. Notably, the underlying adsorption mechanism analyses suggested that multi‐interactions of hydrogen bonds, π–π interactions, and coordinate bonds contribute to the adsorption ability of lignocellulosic‐Fe(OH)3.
Liquid biopsy detects genomic drivers in NSCLC without EGFR mutations by single‐plex testing: WJOG13620L
Authors: Uemura Takehiro , Kenmotsu Hirotsugu , Hazama Daisuke , Teraoka Shunsuke , Kobe Hiroshi , Azuma Koichi , Yamaguchi Teppei , Masuda Takeshi , Yokoyama Toshihide , Otsubo Kohei , Haratani Koji , Hayakawa Daisuke , Oki Masahide , Takemoto Shinnosuke , Ozaki Tomohiro , Akashi Yusaku , Hata Akito , Hashimoto Hiroya , Yamamoto Nobuyuki , Nakagawa Kazuhiko 
Published: November 2023

AbstractBackgroundActionable tumor genomic alterations, primarily EGFR mutations, occur in nearly 70% of Japanese advanced nonsquamous non‐small cell lung cancer (NSCLC) patients. Standard assessment of tumor tissue includes rapid testing for EGFR mutations, ALK fusions and ROS1 fusions. We conducted a prospective observational study (WJOG13620L) of follow‐on next‐generation sequencing of circulating tumor DNA (ctDNA) in patients without driver alterations after EGFR testing.MethodsPatients with untreated advanced (Stage IIIB–IV or relapsed) nonsquamous NSCLC without EGFR mutations according to single‐plex testing of tumor tissue, were enrolled into this study. Patients with other known driver mutations or who underwent comprehensive genomic profiling were excluded. Plasma was analyzed by Guardant360, and the primary endpoint was the proportion of patients with pathogenic gene alterations in at least one of nine genes.ResultsAmong the 72 patients enrolled, ALK and ROS1 fusions were tested in 86.1% and 65.2%, respectively. Alterations in pre‐defined genes were detected in 21 patients (29.2%; 95% confidence interval: 19.0–41.1, p < 0.001 [one‐sided null hypothesis proportion of 10%]), including RET fusion (n = 1) and mutations in KRAS (n = 11), EGFR (n = 5), ERBB2 (n = 3), and BRAF (n = 1). Median time from sample submission to results was 8 days (range, 5–17 days).ConclusionRapid follow‐on comprehensive testing of ctDNA should be considered prior to first‐line treatment for patients with advanced nonsquamous NSCLC when no alterations are detected after single‐plex tissue testing.
Plasma exchange for treatment of a therapy‐related thrombotic microangiopathy in a patient with advanced hepatocellular carcinoma—A case report
Authors: Stortz Marco , Shmanko Kateryna , Kraus Daniel , Gairing Simon , Boedecker‐Lips Simone , Förster Friederich , Weinmann Arndt , Weinmann‐Menke Julia 
Published: November 2023

Key Clinical MessageThrombotic microangiopathies are a side effect of anti‐VEGF therapies, which are often limited to the kidneys but can also occur systemically and be life‐threatening. Screening for increasing proteinuria is essential.AbstractWe present the case of a 65‐year‐old male patient with a multifocal HCC, Barcelona clinic liver cancer (BCLC) classification B at the time of diagnosis. The HCC was treated with nine sessions of transarterial chemoembolization (TACE), and after a progress, the therapy was switched to a combination of atezolizumab and bevacizumab. Five months after therapy change, he presented with an acute kidney injury. The histopathology of the renal biopsy showed findings of a thrombotic microangiopathy (TMA), which we treated with 12 sessions of therapeutic plasma exchange in combination with steroids, resulting in a decreased TMA activity and later in a remission of the TMA. This case suggests the importance of monitoring the kidney function and proteinuria in patients under anti‐vascular endothelial growth factor (VEGF) therapy and shows a rare differential diagnosis for a worsening of kidney function in these patients. Furthermore, it shows that therapeutic plasma exchange might be a valuable therapeutic option for patients with TMA due to anti‐VEGF therapy.
Hemolacria secondary to major depressive disorder and generalized anxiety disorder: A case report
Authors: Razeghian Jahromi Leila , Ghaderian Jahromi Mehdi , Ghavipisheh Mahsa , Ahrari Iman 
Published: November 2023

Key Clinical MessageHemolacria can occur on the basis of a psychiatric disorder without an organic cause. However, this should be a diagnosis of exclusion. Treatment of the underlying psychiatric illness may relieve this condition.AbstractA 24‐year‐old man presented with the chief complaint of bloody tears, which began 4 months earlier after commencing mandatory military service. He had no underlying diseases, and all work‐ups returned normal, though a microscopic examination confirmed red blood cells. He was diagnosed with hemolacria secondary to generalized anxiety disorder and major depressive disorder, responding to propranolol and sertraline. Hemolacria was totally cured after 6 months of treating the underlying psychiatric illness.
Hauser‐Kraus Annulation Initiated Multi‐Cascade Reactions for Facile Access to Functionalized and Fused Oxazepines, Carbazoles and Phenanthridinediones
Authors: Sankara Chenikkayala Siva , Namboothiri Irishi N. N. 
Published: November 2023

AbstractThe Hauser‐Kraus (H−K) annulation of N‐unsubstituted 3‐olefinic oxindoles with 3‐nucleophilic phthalides triggers a cascade of ring expansion and ring contraction reactions through several regioselective steps in one pot. While oxazepines were isolated in the presence of stoichiometric amounts of base at room temperature, carbazoles and phenanthridinediones were the products in the presence of excess base and microwave irradiation. Mechanistic studies guided by stepwise reactions and control experiments revealed that the isolable oxazepine intermediate, formed via ring expansion of the H−K adduct, is the key precursor to carbazole and phenanthridinedione via decarboxylative regioselective cyclizations.
The effect of NaCl and HPAM solution concentration on HPAM gel structure degradation by ultrasonic waves
Authors: Hasiri Mojtaba , Maaref Sepideh , Kantzas Apostolos 
Published: November 2023

AbstractThe present study evaluated the impact of ultrasonic waves on the degradation of partially hydrolyzed polyacrylamide (HPAM) gel structures, focusing on the effects of sonication time, NaCl concentration, and HPAM solution concentration. Results showed that both sonication time and salinity levels play a crucial role in the degradation of HPAM gel, with an increase in sonication time leading to a decrease in the remaining gel and the presence of NaCl in the solution decreasing the residual time required for degradation. The results also revealed that higher levels of salinity expedite the degradation of the gel. In addition, the study discovered that a rise in polymer solution concentration usually results in a reduction in gel degradation. The research suggests there might be an ideal combination of polymer solution and NaCl concentration for achieving the greatest decrease in the degradation rate. For 2‐min sonication, as the salinity of the HPAM solution, with a concentration of up to 5000 ppm, increases, the accumulated energy remains relatively constant. However, when the polymer solution concentration is increased, the accumulated energy becomes more sensitive to changes in salinity. The results of this study provide valuable insight into the interplay between polymer solution concentration, salt concentration, and the energy required for gel degradation, which can be applied in various fields including the oil and gas industry, petroleum processing, and environmental remediation.
An integrated intervention programme for couples facing colorectal cancer: A randomized controlled trial
Authors: Wang Zhiming , Chen Meizhen , Cao Qian , Gong Jiali , Zhao Jie , Lin Chunyan , Luo Huamin , Wu Xinyu , Chen Ying , Li Qiuping 
Published: November 2023

AbstractBackgroundUnder the guidance of a preliminary Live with Love Conceptual Framework, a Caring for Couples Coping with Colorectal Cancer (4Cs: CRC) programme was designed specifically for colorectal cancer couples. The objectives of this study included examining the efficacy of the programme for couples adapting to colorectal cancer and comparing the effects of different intervention delivery modes (online, face‐to‐face and blended) on couple outcomes.MethodsA four‐arm randomized controlled trial was conducted among Chinese colorectal cancer couples. Couples were randomly assigned to an online intervention, a face‐to‐face intervention, a blended intervention or a control group. Self‐efficacy, dyadic coping, communication and dyadic outcomes (physical and mental health, negative and positive emotions and marital satisfaction) were evaluated at baseline and 6 weeks later. Analysis of variance (ANOVA) and repeated measures ANOVA were employed to assess between‐group differences and within‐group effects in the four groups, respectively.ResultsA total of 179 couples completed the 6‐week study and post‐study assessments. The intervention showed generally medium‐to‐large effects across multiple measured outcomes, including self‐efficacy, dyadic coping, communication, mental health, negative emotions and positive emotions for both patients and spouse caregivers. Additionally, interventions delivered through different modes produced equally significant effects on couple outcomes.ConclusionsThe integrated intervention programme is effective in improving cancer adaptation in colorectal cancer couples. Long‐term follow‐up and a mix of quantitative and qualitative assessments are crucial for further evaluation of the programme.Trial registrationRetroactive registration is under review.
Maize yield and dry milling grain quality trade‐offs in Argentinean flint germplasm
Authors: Abdala Lucas J. , Alvarez Prado Santiago , Donadio Pablo , Borrás Lucas 
Published: November 2023

AbstractTrade‐offs between yield and grain quality for dry milling are common in maize (Zea mays L.), but the magnitude of these correlations can differ depending on the specific quality trait. We aimed to quantify the relationship between yield and grain traits known to affect dry milling, with a focus on describing the genetic control of the traits that show no negative yield effects. For this, we tested commercial hybrids differing in grain hardness and a recombinant inbred line (RIL) population with their derived hybrids. Commercial hybrids showed that grain hardness (test weight, flotation index, and vitreousness) were all negatively correlated to yield, while screen retention, a key trait for the milling industry, showed no correlation with yield. Also, while all grain quality traits in the RIL and derived hybrid populations showed high heritability (>0.77), results showed that adequate hybrid test weight (>76 kg hL−1) and flotation index (<25%) did not depend on its midparental performance. High hybrid vitreousness was only achieved when both parental inbreds had high vitreousness. Hybrid screen retention was accurately predicted by an environmentally consistent quantitative trait locus and by inbred genetic and phenotypic information (p < 0.001). This suggests a strong genetic control that can be exploited without yield penalties. Our study shows that the trade‐off between yield and grain quality is trait dependent, and highlights that only some traits measured in inbreds can help predict derived hybrid performance for dry milling.
Peroxygenase‐Catalysed Sulfoxidations in Non‐Aqueous Media
Authors: Li Huanhuan , Shen Qianqian , Zhou Xiaoying , Duan Peigao , Hollmann Frank , Huang Yawen , Zhang Wuyuan 
Published: November 2023

AbstractChiral sulfoxides are valuable building blocks in asymmetric synthesis. However, the biocatalytic synthesis of chiral sulfoxides is still challenged by low product titres. Herein, we report the use of peroxygenase as a catalyst for asymmetric sulfoxidation under non‐aqueous conditions. Upon covalent immobilisation, the peroxygenase showed stability and activity under neat reaction conditions. A large variety of sulfides was converted into chiral sulfoxides in very high product concentration with moderate to satisfactory optical purity (e. g. 626 mM of (R)‐methyl phenyl sulfoxide in approx. 89 % ee in 48 h). Further polishing of the ee value via cascading methionine reductase A (MsrA) gave>99 % ee of the sulfoxide. The robustness of the enzymes and high product titer is superior to the state‐of‐the‐art methodologies. Gram‐scale synthesis has been demonstrated. Overall, we demonstrated a practical and facile catalytic method to synthesize chiral sulfoxides.
Marginal value analysis reveals shifting importance of migration habitat for waterfowl under a changing climate
Authors: Burner Ryan C. , Golas Benjamin D. , Aagaard Kevin J. , Lonsdorf Eric V. , Thogmartin Wayne E. 
Published: November 2023

AbstractMigratory waterfowl are an important resource for consumptive and non‐consumptive users alike and provide tremendous economic value in North America. These birds rely on a complex matrix of public and private land for forage and roosting during migration and wintering periods, and substantial conservation effort focuses on increasing the amount and quality of target habitat. Yet, the value of habitat is a function not only of a site's resources but also of its geographic position and weather. To quantify this value, we used a continental‐scale energetics‐based model of daily dabbling duck movement to assess the marginal value of lands across the contiguous United States during the non‐breeding period (September to May). We examined effects of eliminating each habitat node (32 × 32 km) in both a particularly cold and a particularly warm winter, asking which nodes had the largest effect on survival. The marginal value of habitat nodes for migrating dabbling ducks was a function of forage and roosting habitat but, more importantly, of geography (especially latitude and region). Irrespective of weather, nodes in the Southeast, central East Coast, and California made the largest positive contributions to survival. Conversely, nodes in the Midwest, Northeast, Florida, and the Pacific Northwest had consistent negative effects. Effects (positive and negative) of more northerly nodes occurred in late fall or early spring when climate was often severe and was most variable. Importance and effects of many nodes varied considerably between a cold and a warm winter. Much of the Midwest and central Great Plains benefited duck survival in a warm winter, and projected future warming may improve the value of lands in these regions, including many National Wildlife Refuges, for migrating dabbling ducks. Our results highlight the geographic variability in habitat value, as well as shifts that may occur in these values due to climate change.
Belowground competition and niche partitioning between the Babassu palm and Urochloa grass in eastern Amazonian pastures
Authors: de Alencar Pageú André Brenner , de Deus Ribeiro Lima Odenilson , Diniz Daniel Cutrim , da Silva Luciana Sousa , Detert Maria Elisabeth , Gehring Christoph 
Published: November 2023

AbstractMuch of deforested Amazonia is dominated by pastures planted with exotic Urochloa (syn Brachiaria) grass, containing interspersed, ruderal Babassu palm (Attalea speciosa). This two‐species system offers the opportunity to investigate how two very competitive species interact. We investigated three monospecific Urochloa pastures containing dispersed Babassu palm clusters in the eastern periphery of Amazonia. We mapped 0‐ to 50‐cm Babassu and Urochloa root profiles at three distances representing contrasting relative dominance: “within clusters” (0.4–0.6 m from adult palm, Babassu‐dominated), “close” (2.5–4.0 m), and “far” (>8.0–10.0 m, Urochloa‐dominated). Total Babassu root share count was 76.0% within Babassu clusters, as opposed to Urochloa root share count (80.0%) far from clusters, confirming our experimental dominance gradient. Babassu and Urochloa root diameter composition differed strongly, whereas 44.6% of all Babassu roots were mid‐diameter or coarse; 83.0% of all Urochloa roots were fine graminoid. Vertical root profiles likewise differed: Babassu coarse and mid‐diameter roots concentrated within clusters at 20–50 cm depth, well protected against disturbance, though Babassu mid‐diameter roots did extend up to 10 m, indicating active foraging at long distances. By contrast, Urochloa mid‐diameter and coarse roots concentrated in the topsoil (70.4% in top 20 cm). Notably, 45.0% of all Urochloa fine roots but only 29.3% of deeper rooting Babassu concentrated in the top 0–10 cm. Both Urochloa mid‐diameter (R = 0.49) and fine roots (R = 0.40) correlated positively with Urochloa aboveground biomass. Fine‐root fine‐scale variability was high, with high‐density hotspots of both species in the topsoil. Babassu vertical root profiles were unaffected by the degree of interspecific competitive confrontation, whereas Urochloa fine roots were significantly shallower within than outside of Babassu clusters. Though differing Babassu and Urochloa vertical root profiles do support the notion of niche expansion caused by Babassu clusters within the vast Urochloa pastures throughout Amazonia, we also find a strong horizontal and vertical niche overlap with no indication of fine‐scale root segregation, indicating direct competition between both species, possibly in a dynamic state of “mutual invasability.” In practical terms, our findings call for the diversification of Amazonian pastures beyond this two‐species system in order to increase productivity and ecological efficiency.
The competitive exclusion–tolerance rule explains habitat partitioning among co‐occurring species of burying beetles
Authors: Burke Kevin W. , Groulx Adam F. , Martin Paul R. 
Published: November 2023

AbstractHabitat partitioning among co‐occurring, ecologically similar species is widespread in nature and thought to be an important mechanism for coexistence. The factors that cause habitat partitioning, however, are unknown for most species. We experimentally tested among three alternative hypotheses to explain habitat partitioning among two species of co‐occurring burying beetle (Nicrophorus) that occupy forest (Nicrophorus orbicollis) and wetland (Nicrophorus hebes) habitats. Captive experiments revealed that the larger N. orbicollis (forest) was consistently dominant to N. hebes (wetland) in competitive interactions for carcasses that they require for reproduction. Transplant enclosure experiments in nature revealed that N. hebes had poor reproductive success whenever the dominant N. orbicollis was present. In the absence of N. orbicollis, N. hebes performed as well, or better, in forest versus its typical wetland habitat. In contrast, N. orbicollis performed poorly in wetlands regardless of the presence of N. hebes. These results support the competitive exclusion–tolerance rule where the competitively dominant N. orbicollis excludes the subordinate N. hebes from otherwise suitable or preferable forest habitat, while the subordinate N. hebes is uniquely able to tolerate the challenges of breeding in wetlands. Transplant experiments further showed that carcass burial depth—an important trait thought to enhance the competitive ability of the dominant N. orbicollis—is costly in wetland habitats. In the presence of N. hebes, N. orbicollis buried carcasses deeper; deeper burial is thought to provide a competitive advantage in forests but further compromised the reproductive success of N. orbicollis in wetlands. Overall, results provide evidence that the competitive exclusion–tolerance rule underlies habitat partitioning among ecologically similar species and that the traits important for competitive dominance in relatively benign environments are costly in more challenging environments, consistent with a trade‐off.