bluuebunny/crossref_metadata_2025_split huggingface dataset:
Looking at the cultural heritage proclamations of Ethiopia: conceptualisation and management of cultural heritage
Authors: Zewdu Mengistie 
Published: January 2024

AbstractThe main purpose of this paper is to explore how the conceptualisation and management of cultural heritage have been treated in the cultural heritage proclamations of Ethiopia. The analysis of the four cultural heritage proclamations reveals that the notion of cultural heritage improves from the first to the fourth proclamation. In the first two proclamations, the term antiquity was employed, and the latter two employed the term of cultural heritage. The 1966 proclamation included antiquities that were dated prior to 1850 EC, while the 1989 proclamation removed this cutoff date and expounded upon the definition of antiquities. The 2000 proclamation replaced the term antiquity with cultural heritage and introduced the concept of intangible cultural heritage. In terms of the management of cultural heritage, the differences between the 1989 and 2000 proclamations are quite minimal. The 2014 proclamation attempted to classify cultural heritage into national and regional cultural heritage. It also defined important components of intangible cultural heritage. The management of cultural heritage exhibits some evolution from the first to the last proclamation. However, due to the diversified nature of cultural heritage conceptualisation and management, it will be important for additional legislation to be issued separately for movable, immovable and intangible cultural heritage, for example. This study argues that strong legal and institutional frameworks should be established to properly protect, conserve and study cultural heritage.
Update on vitamin D role in severe infections and sepsis
Authors: Cutuli Salvatore Lucio , Ferrando Elena Sancho , Cammarota Fabiola , Franchini Emanuele , Caroli Alessandro , Lombardi Gianmarco , Tanzarella Eloisa Sofia , Grieco Domenico Luca , Antonelli Massimo , De Pascale Gennaro 
Published: January 2024

AbstractSevere infections frequently require admission to the intensive care unit and cause life-threatening complications in critically ill patients. In this setting, severe infections are acknowledged as prerequisites for the development of sepsis, whose pathophysiology implies a dysregulated host response to pathogens, leading to disability and mortality worldwide.Vitamin D is a secosteroid hormone that plays a pivotal role to maintain immune system homeostasis, which is of paramount importance to resolve infection and modulate the burden of sepsis. Specifically, vitamin D deficiency has been widely reported in critically ill patients and represents a risk factor for the development of severe infections, sepsis and worse clinical outcomes. Several studies have demonstrated the feasibility, safety and effectiveness of vitamin D supplementation strategies to improve vitamin D body content, but conflictual results support its benefit in general populations of critically ill patients. In contrast, small randomised clinical trials reported that vitamin D supplementation may improve host-defence to pathogen invasion via the production of cathelicidin and specific cytokines. Nonetheless, no large scale investigations have been designed to specifically assess the impact of vitamin D supplementation on the outcome of critically ill septic patients admitted to the intensive care unit.
“Zero Cost” Majority Attacks on Permissionless Proof of Work Blockchains
Authors: Gans Joshua S. , Halaburda Hanna 
Published: January 2024

The core premise of permissionless blockchains is their reliable and secure operation without the need to trust any individual agent. At the heart of blockchain consensus mechanisms is an explicit cost (e.g., mining cost) for participation in the network and the opportunity to add blocks to the blockchain. A key rationale for that cost is to make attacks on the network, which could be theoretically carried out if a majority of nodes were controlled by a single entity, too expensive to be worthwhile. We demonstrate that a majority attacker can successfully attack with a negative net cost when accounting for the mining rewards the attacker collects during the attack. This shows that the protocol mechanisms are insufficient to create a secure network, emphasizing the importance of socially driven mechanisms external to the protocol. At the same time, negative cost enables a new type of majority attack that is more likely to elude external scrutiny. This paper was accepted by David Simchi-Levi, finance.
COMPARATIVE EVALUATION OF NATIVE JOINT INFECTIONS DURING COVID AND PRE-COVID PERIOD AT A TERTIARY CENTRE
Authors: Raghavendra Ram Mohan , Panwalkar Parag , Veravalli Karunakar , Tofighi Mehdi , Mofidi Ali 
Published: January 2024

AbstractIntroductionThe short and long-term effects of covid infection are still being explored. Following a series of joint infections noted in patients presenting to a tertiary care hospital during the COVID-19 pandemic, we explored if there was any difference in the incidence of these joint infections when compared to pre-COVID era.AimThe aim of this study was to determine the incidence of native joint infections during COVID and pre-COVID period and compare the two groups for any differences.MethodologyPatients diagnosed with septic arthritis over the 15th months of lockdown were studied and were compared with the same period prior to Covid-19 infection. The patient characteristics, the rate of septic arthritis, the presence of recent Covid-19 infection, delay in diagnosis and the difference in the microbiology between the two groups was studied.ResultsThere were 36 joint infections during the COVID period in comparison to 46 joint infections during pre-COVID period. Both groups had similar mean age. Knee was the most common joint involved in both groups. About 50% (n = 18) of the joint infections during the COVID period did not grow any micro-organisms even after extended culture, which was higher in comparison to the pre-COVID group (35%, n = 16).ConclusionThe culture negative group have significantly reduced markers of infection. The was no increase in the rate of septic arthritis however there was an increase in culture negative arthritis denoting a possible outbreak of reactive arthritis in the Covid-19 period.
“You can because you do and you do, because you can”: Using interpretative description to examine what it means to be a physically literate adult living with multiple chronic conditions
Authors: Petrusevski Celeste , Joy MacDermid , Wilson Michael , Richardson Julie 
Published: January 2024

Aims
Physical literacy is an emerging strategy to increase participation in movement activities for children and youth, however little is known about how to frame physical literacy for aging adults. The purpose of this qualitative study was to explore how adults with multiple chronic conditions describe physically literacy for adults and to understand the needs, preferences, barriers, and facilitators to acquiring and maintaining physical literacy despite fluctuations in health status.

Methods
Sixteen semi-structured interviews were conducted with working and retired teachers in Ontario, Canada, with varying self-identified physical activity levels and are living with 2 or more chronic conditions. A semi-structured interview guide was used to conduct the interviews. Thematic analysis was used to analyze the data.

Results
Participants identified 5 themes when describing physical literacy for adults: understanding one’s body, conscious commitment to movement, access to and knowledge of rehabilitation health resources, valuable physical activities, and confident problem solver. Results indicate that when acquiring physical literacy for adults, there are important new constructs, such as self-management and the awareness of rehabilitation strategies to maintain mobility, that differ from the traditional physical literacy model.

Conclusions
To improve function and mobility outcomes for adults living with chronic conditions, programs should be guided by a physical literacy framework that addresses the needs unique to aging adults, such as understanding the changes that occur with aging, self-monitoring mobility changes and participating in rehabilitation strategies.
Validating the Emergency Department Avoidability Classification (EDAC): A cluster randomized single-blinded agreement study
Authors: Strum Ryan P. , Mondoux Shawn , Mowbray Fabrice I. , Griffith Lauren E. , Worster Andrew , Tavares Walter , Miller Paul , Aryal Komal , Sivakumaran Ravi , Costa Andrew P. 
Published: January 2024

IntroductionThe Emergency Department Avoidability Classification (EDAC) retrospectively classifies emergency department (ED) visits that could have been safely managed in subacute primary care settings, but has not been validated against a criterion standard. A validated EDAC could enable accurate and reliable quantification of avoidable ED visits. We compared agreement between the EDAC and ED physician judgements to specify avoidable ED visits.Materials and methodsWe conducted a cluster randomized, single-blinded agreement study in an academic hospital in Hamilton, Canada. ED visits between January 1, 2019, and December 31, 2019 were clustered based on EDAC classes and randomly sampled evenly. A total of 160 ED visit charts were randomly assigned to ten participating ED physicians at the academic hospital for evaluation. Physicians judged if the ED visit could have been managed appropriately in subacute primary care (an avoidable visit); each ED visit was evaluated by two physicians independently. We measured interrater agreement between physicians with a Cohen’s kappa and 95% confidence intervals (CI). We evaluated the correlation between the EDAC and physician judgements using a Spearman rank correlation and ordinal logistic regression with odds ratios (ORs) and 95% CIs. We examined the EDAC’s precision to identify avoidable ED visits using accuracy, sensitivity and specificity.ResultsED physicians agreed on 139 visits (86.9%) with a kappa of 0.69 (95% CI 0.59–0.79), indicating substantial agreement. Physicians judged 96.2% of ED visits classified as avoidable by the EDAC as suitable for management in subacute primary care. We found a high correlation between the EDAC and physician judgements (0.64), as well as a very strong association to classify avoidable ED visits (OR 80.0, 95% CI 17.1–374.9). The EDACs avoidable and potentially avoidable classes demonstrated strong accuracy to identify ED visits suitable for management in subacute care (82.8%, 95% CI 78.2–86.8).DiscussionThe EDAC demonstrated strong evidence of criterion validity to classify avoidable ED visits. This classification has important potential for accurately monitoring trends in avoidable ED utilization, measuring proportions of ED volume attributed to avoidable visits and informing interventions intended at reducing ED use by patients who do not require emergency or life-saving healthcare.
Impaired function in the lung periphery following COVID‐19 is associated with lingering breathing difficulties
Authors: Kjellberg Sanna , Holm Alexander , Berguerand Nicolas , Sandén Helena , Schiöler Linus , Olsén Monika Fagevik , Olin Anna‐Carin 
Published: January 2024

AbstractLingering breathing difficulties are common after COVID‐19. However, the underlying causes remains unclear, with spirometry often being normal. We hypothesized that small airway dysfunction (SAD) can partly explain these symptoms. We examined 48 individuals (32 women, 4 hospitalized in the acute phase) who experienced dyspnea and/or cough in the acute phase and/or aftermath of COVID‐19, and 22 non‐COVID‐19 controls. Time since acute infection was, median (range), 65 (10–131) weeks. We assessed SAD using multiple breath washout (MBW) and impulse oscillometry (IOS) and included spirometry and diffusing‐capacity test (DLCO). One‐minute‐sit‐to‐stand test estimated physical function, and breathing difficulties were defined as answering “yes” to the question “do you experience lingering breathing difficulties?” Spirometry, DLCO, and IOS were normal in almost all cases (spirometry: 90%, DLCO: 98%, IOS: 88%), while MBW identified ventilation inhomogeneity in 50%. Breathing difficulties (n = 21) was associated with increased MBW‐derived Sacin. However, physical function did not correlate with SAD. Among individuals with breathing difficulties, 25% had reduced physical function, 25% had SAD, 35% had both, and 15% had normal lung function and physical function. Despite spirometry and DLCO being normal in almost all post‐COVID‐19 individuals, SAD was present in a high proportion and was associated with lingering breathing difficulties.
Synergistic inhibitive effect of a hybrid zinc oxide-benzalkonium chloride composite on the corrosion of carbon steel in a sulfuric acidic solution
Authors: AlBeladi Muntathir , Geesi Mohammed H. , Riadi Yassine , Alahiane Mustapha , Aljohani Talal A. , Berisha Avni , Reka Arianit , Kaiba Abdellah , Ouerghi Oussama 
Published: January 2024

Abstract
Zinc oxide and quaternary ammonium-type surfactants have been separately recognized for their anti-corrosive efficiencies. Their composite, not investigated so far, could provide a synergetic anti-corrosion effect. In this respect, the aim of this study is to synthesize a composite material consisting of zinc oxide and benzalkonium chloride (ZnO-BAC) in varying mass ratios (3:1, 1:1, and 1:3). The inhibitory properties of the ZnO-BAC composite against carbon steel corrosion in a 0.5 M sulfuric acid solution were assessed under ambient conditions. First, X-ray photoelectron spectroscopy and Fourier transform infrared spectroscopy were used to examine the chemical structure of the prepared composite. Then, the corrosion inhibitive performance of the devised inhibitors was screened using electrochemical, hydrogen collection, and weight loss measurements. Further, the surface morphology was examined using a scanning electron microscope, both before and after immersion in the corrosion medium. The electrochemical measurements indicate that the prepared inhibitor exhibits a predominant cathodic inhibition behavior and the maximum inhibition efficiency, approximately 91.9%, was achieved for one-to-one mass ratio. Similar results were obtained from weight loss and hydrogen evolution measurements, which showed that the ZnO-BAC composite reduced the corrosion rate of carbon steel by 69.9% and 64.9%, respectively. Finally, molecular dynamics and an adsorption equilibrium model were used to elucidate the mechanism of corrosion inhibition by the ZnO-BAC composite, which exhibits a high adsorption energy on the iron surface.
Effect of tool rotational speed on friction stir spot welds of AZ31B Mg alloy to AISI 304 stainless steel
Authors: Ekinci Omer 
Published: January 2024

Abstract
AZ31B Mg alloy were welded to AISI 304 stainless steel (which is a very challenging task because of their huge different chemical and physical features) by friction stir spot welding (FSSW) at different tool rotation speeds (700, 1000, and 1300 rpm) while keeping other conditions the same. Welds were evaluated and compared by examining their cross-sectional geometry, XRD pattern, tensile shear strength, fracture way and area. From cross-sections of welds, it was obtained that joining area expanded when speed was enhanced and the weld made through 1300 rpm had the largest one. Therefore, weld fabricated with the highest speed of 1300 rpm displayed the biggest tensile shear load of 3741 N while that manufactured with the lowest speed of 700 rpm possessed the lowest of 2430 N. All welds showed tensile shear type fracture and fracture occurred from the hooking regions where joining took place. From the fracture joint region, the weld of 700 rpm had the smallest joined area, whereas that of 1300 rpm showed the biggest. Higher speed produced a stronger joint, which agreed with a bigger bonding area and broken joint region. Also, joint became more ductile with increasing speed. Some phases were detected in joints.
Transmissible topological edge states based on Su–Schrieffer–Heeger photonic crystals with defect cavities
Authors: Yan Qiuchen , Ma Rui , Lyu Qinghong , Hu Xiaoyong , Gong Qihuang 
Published: January 2024

Abstract
Topological photonic crystals have great potential in the application of on-chip integrated optical communication devices. Here, we successfully construct the on-chip transmissible topological edge states using one-dimensional Su–Schrieffer–Heeger (SSH) photonic crystals with defect cavities on silicon-on-insulator slab. Different coupling strengths between the lateral modes and diagonal modes in photonic crystal defect cavities are used to construct the SSH model. Furthermore, two photonic SSH-cavity configurations, called α and β configurations, are designed to demonstrate the topological edge states. Leveraging the capabilities of photonic crystal transverse electric modes with on-chip transmission, we introduced a waveguide to excite a boundary defect cavity and found that the transmission peak of light, corresponding to the topological edge state, can be received in another boundary defect cavity, which is caused by the tunnel effect. Moreover, the position of this peak experiences a blue shift as the defect cavity size increases. Therefore, by tuning the size of the SSH defect cavity, on-chip wavelength division multiplexing function can be achieved, which is demonstrated in experiments. The ultrafast response time of one operation can be less than 20 fs. This work harmonizes the simplicity of one-dimensional SSH model with the transmissibility of two-dimensional photonic crystals, realizing transmissible on-chip zero-dimensional topological edge states. Since transmission peaks are highly sensitive to defect cavity size, this configuration can also serve as a wavelength sensor and a reconfigurable optical device, which is of substantial practical value to on-chip applications of topological photonics.
The third way: object reordering as ambiguous labeling resolution
Authors: Stegovec Adrian 
Published: January 2024

Abstract
This paper examines free object order alternation in ditransitives, focusing on Slovenian. It is shown that neither a scrambling nor a base generation analysis is fully satisfactory. A new analysis based on the Labeling Algorithm is proposed, where it is argued that the introduction of a second object creates an ambiguous labeling scenario ({NP,VP}), which has two equivalent resolutions: (i) movement of the VP with the first object inside, or (ii) movement of the second object. This is shown to derive both free object order in the general case and the restrictions on object order in select contexts, as due to the specifics of the VP-movement analysis it is possible for selectional restrictions to filter out either derivation (i) or (ii).
Brain expression profiles of two SCN1A antisense RNAs in children and adolescents with epilepsy
Authors: Schneider Marius Frederik , Vogt Miriam , Scheuermann Johanna , Müller Veronika , Fischer-Hentrich Antje H. L. , Kremer Thomas , Lugert Sebastian , Metzger Friedrich , Kudernatsch Manfred , Kluger Gerhard , Hartlieb Till , Noachtar Soheyl , Vollmar Christian , Kunz Mathias , Tonn Jörg Christian , Coras Roland , Blümcke Ingmar , Pace Claudia , Heinen Florian , Klein Christoph , Potschka Heidrun , Borggraefe Ingo 
Published: January 2024

Abstract

Objective
Heterozygous mutations within the voltage-gated sodium channel α subunit (SCN1A) are responsible for the majority of cases of Dravet syndrome (DS), a severe developmental and epileptic encephalopathy. Development of novel therapeutic approaches is mandatory in order to directly target the molecular consequences of the genetic defect. The aim of the present study was to investigate whether cis-acting long non-coding RNAs (lncRNAs) of SCN1A are expressed in brain specimens of children and adolescent with epilepsy as these molecules comprise possible targets for precision-based therapy approaches.

Methods
We investigated SCN1A mRNA expression and expression of two SCN1A related antisense RNAs in brain tissues in different age groups of pediatric non-Dravet patients who underwent surgery for drug resistant epilepsy. The effect of different antisense oligonucleotides (ASOs) directed against SCN1A specific antisense RNAs on SCN1A expression was tested.

Results
The SCN1A related antisense RNAs SCN1A-dsAS (downstream antisense, RefSeq identifier: NR_110598) and SCN1A-usAS (upstream AS, SCN1A-AS, RefSeq identifier: NR_110260) were widely expressed in the brain of pediatric patients. Expression patterns revealed a negative correlation of SCN1A-dsAS and a positive correlation of lncRNA SCN1A-usAS with SCN1A mRNA expression. Transfection of SK-N-AS cells with an ASO targeted against SCN1A-dsAS was associated with a significant enhancement of SCN1A mRNA expression and reduction in SCN1A-dsAS transcripts.

Conclusion
These findings support the role of SCN1A-dsAS in the suppression of SCN1A mRNA generation. Considering the haploinsufficiency in genetic SCN1A related DS, SCN1A-dsAS is an interesting target candidate for the development of ASOs (AntagoNATs) based precision medicine therapeutic approaches aiming to enhance SCN1A expression in DS.
Analysis of the SARS-CoV-2 nsp12 P323L/A529V mutations: coeffect in the transiently peaking lineage C.36.3 on protein structure and response to treatment in Egyptian records
Authors: Abd-Elshafy Dina N. , Nadeem Rola , Nasraa Mohamed H. , Bahgat Mahmoud M. 
Published: January 2024

Abstract
SARS-CoV-2 nsp12, the RNA-dependent RNA-polymerase plays a crucial role in virus replication. Monitoring the effect of its emerging mutants on viral replication and response to antiviral drugs is important. Nsp12 of two Egyptian isolates circulating in 2020 and 2021 were sequenced. Both isolates included P323L, one included the A529V. Tracking A529V mutant frequency, it relates to the transience peaked C.36.3 variant and its parent C.36, both peaked worldwide on February–August 2021, enlisted as high transmissible variants under investigation (VUI) on May 2021. Both Mutants were reported to originate from Egypt and showed an abrupt low frequency upon screening, we analyzed all 1104 nsp12 Egyptian sequences. A529V mutation was in 36 records with an abrupt low frequency on June 2021. As its possible reappearance might obligate actions for a candidate VUI, we analyzed the predicted co-effect of P323L and A529V mutations on protein stability and dynamics through protein structure simulations. Three available structures for drug–nsp12 interaction were used representing remdesivir, suramin and favipiravir drugs. Remdesivir and suramin showed an increase in structure stability and considerable change in flexibility while favipiravir showed an extreme interaction. Results predict a favored efficiency of the drugs except for favipiravir in case of the reported mutations.