bluuebunny/crossref_metadata_2025_split huggingface dataset:
Negative association of donor age with CD34+ cell dose in mixture allografts of G-CSF-primed bone marrow and G-CSF-mobilized peripheral blood harvests
Authors: Yan Li , Yingjun Chang , Lanping Xu , Xiaohui Zhang , Xiaojun Huang 
Published: January 2024

Background
The effects of donor characteristics on CD34+ cell dose remain controversial. Recently, we developed a novel haploidentical transplant protocol, in which mixture allografts of granulocyte colony-stimulating factor (G-CSF)-primed bone marrow (G-BM) and G-CSF-mobilized peripheral blood (G-PB) were used. The aim of this study was to investigate the effects of donor characteristics on CD34+ cell dose in mixture allografts of G-BM and G-PB.

Methods
A total of 162 healthy adult donors, who underwent bone marrow harvest and peripheral blood collection between January 2009 and November 2010 in Peking University People's Hospital, were prospectively investigated. G-CSF was administered subcutaneously at a dose of 5 μg/kg once a day for 5–6 consecutive days. Bone marrow and peripheral blood stem cells were harvested on the fourth day and fifth day, respectively. A final total CD34+ cell dose less than 2×106 cells/kg recipient body weight was considered a poor mobilization.

Results
Of the 162 donors, 31 (19.1%) did not attain this threshold. The obtained median CD34+ cell doses in bone marrow, peripheral blood, and mixture allografts were 0.83×106/kg, 2.40×106/kg, and 3.47×106/kg, respectively. Multiple regression analysis showed that donor age had a significant negative effect on CD34+ cell dose in either G-BM, or G-PB, or mixture allografts of G-BM and G-PB. And a 1-year increase in age was associated with a 5.6% decrease in the odds of achieving mobilization cutoff. No significant correlation was found for donor gender, body mass index (BMI), and weight.

Conclusion
Donor age is the only factor among the four parameters, including age, gender, weight, and BMI, that influence CD34+ cell dose in mixture allografts of G-BM and G-PB, and younger donors should be chosen to obtain sufficient CD34+ cells for transplantation.
A comparison of unilateral and bilateral pedicle screw fixation combined with transforaminal lumbar interbody fusion for lumbar degenerative diseases
Authors: Xiaoming Yang , Hong Wang , Quanlai Zhao , Hongguang Xu , Ping Liu , Yuelong Jin 
Published: January 2024

Background
Bilateral transpedicular screw fixation in conjunction with interbody fusion is widely used to treat lumbar degenerative diseases; however, there are some disadvantages of using this fixation system. This study comparatively analyzes the results of unilateral and bilateral pedicle screw fixation combined with transforaminal lumbar interbody fusion (TLIF) for one-level lumbar degenerative diseases.

Methods
Sixty-six cases with one-level lumbar degenerative diseases were studied. The patients were divided according to surgical approach into a unilateral group (Group A) and a bilateral group (Group B). The patients were evaluated for pain by visual analog scale (VAS) and Oswestry Disability Index (ODI). Operating time, blood loss, duration of hospitalization, and complication rate were also evaluated. Patients were examined at 1, 3, 6, and 12 months postoperatively and every year thereafter.

Results
Group A patients' average preoperative VAS and ODI scores were 7.03 ± 0.98 and (64.22±6.38)%, respectively, significantly decreased to 2.91 ± 0.88 and (14.42±2.08)%, respectively, at the last follow-up (P = 0.000). In Group B, the average preoperative VAS and ODI scores were 6.79±0.86 and (63.22±4.70)%, respectively, significantly decreased to 3.12±0.96 and (14.62±2.08)%, respectively, at the last follow-up (P=0.000). No significant difference in the duration of hospitalization was found between groups. Operating time and blood loss of (125.9±13.0) minutes and (211.4±28.3) ml, respectively, in Group A were significantly less than (165.2±15.3) minutes and (258.6±18.3) ml, respectively, in Group B (P=0.000). All patients achieved good bone union and had no pseudarthrosis at the last follow-up.

Conclusions
There are no clinical differences between unilateral and bilateral pedicle screw fixation combined with TLIF for one-level lumbar degenerative diseases. Unilateral fixation reduces operating time, bleeding, and cost of hospitalization.
Application of a new combined model including radiological indicators to predict difficult airway in patients undergoing surgery for cervical spondylosis
Authors: Xu Mao , Li Xiaoxi , Wang Jun , Guo Xiangyang 
Published: January 2024

Background
Airway management is crucial in clinical anesthesia. Many complications associated with airway management result from unexpected difficult airway, but predicting a difficult airway is a major challenge. We investigated the efficacy of a new combined model including radiological indicators to predict difficult airway in patients undergoing surgery for cervical spondylosis, a population with a high incidence of difficult airway.

Methods
We randomly enrolled 303 patients scheduled for elective surgery for cervical spondylosis at Peking University Third Hospital between August 2012 and March 2013. Preoperatively, patients were evaluated for difficult airway according to a clinical index and parameters on lateral cervical radiographs and magnetic resonance images. Difficult airway was defined as Cormack-Lehane grades III-IV. Logistic regression was used to identify a combined (clinical and radiological) model for difficult airway. A receiver operating characteristic (ROC) curve was used to describe the effectiveness of prediction.

Results
We identified three clinical predictive factors using the ROC curve: mouth opening, sternomental distance, and neck mobility. We created a clinical model using three factors: gender, age, and mouth opening, with odds ratios (OR) of 0.370, 1.034, and 0.358, respectively. Using the clinical and radiological parameters, we formulated a combined model with five risk factors: gender, mouth opening, atlanto-occipital gap, the angle from the second to sixth cervical vertebraes in the neutral position, and the angle difference of δ (the angle between the laryngeal axis and the epiglottic axis) from the neutral position to extension (OR: 0.107, 0.355, 0.846, 1.057, and 0.952, respectively). The sensitivity and specificity of the combined model were 80.0% and 65.7%, respectively, and the ROC curve confirmed that the combined model was better than any single clinical predictor and the clinical model.

Conclusion
The efficacy of the combined model including both clinical and radiological indicators was better than any single clinical predictor or the clinical model in patients undergoing elective surgery for cervical spondylosis.
Immunosuppression for 6–8 weeks after modified donor lymphocyte infusion reduced acute graft-versus-host disease without influencing graft-versus-leukemia effect in haploidentical transplant
Authors: Chenhua Yan , Lanping Xu , Daihong Liu , Huan Chen , Yu Wang , Kaiyan Liu , Xiaojun Huang 
Published: January 2024

Background
In haploidentical hematopoietic stem cell transplantation (HSCT), the duration of graft-versus-host disease (GVHD) prophylaxis after modified donor lymphocyte infusion (DLI) was the only risk factor of DLI-associated grades 3–4 acute GVHD. However, the successful application of modified DLI depended not only on the reduction of severe GVHD, but also on the preservation of graft-versus-leukemia (GVL) effect. Therefore, this study was performed to compare the impact of prophylaxis for 6–8 weeks and prophylaxis for <6 weeks on GVL effect after modified DLI in haploidentical HSCT.

Methods
A total of 103 consecutive patients developing hematological relapse or minimal residual disease (MRD)-positive status after haploidentical HSCT and receiving modified DLI were investigated retrospectively. Fifty-two patients received prophylaxis for 6–8 weeks after modified DLI; the remaining 51 patients received prophylaxis for <6 weeks.

Results
First, compared with prophylaxis for <6 weeks, prophylaxis for 6–8 weeks reduced incidence of relapse in total patients (26.6% vs. 69.0%, P <0.001). Besides, prophylaxis for 6–8 weeks also reduced incidence of relapse in 54 patients developing hematological relapse post-transplant (P=0.018) and in 49 patients developing MRD-positive status post-transplant (P <0.001). Second, prophylaxis for 6–8 weeks reduced incidence of acute GVHD (P <0.05), reduced the therapeutic application of immunosuppressive agents (P=0.019), but increased the incidence of chronic GVHD (P<0.05). Third, prophylaxis for 6–8 weeks improved overall survival and disease-free survival in total patients, as well as in patients developing hematological relapse post-transplant and in patients developing MRD-positive status post-transplant (P <0.05).

Conclusions
In haploidentical HSCT, prophylaxis for 6–8 weeks after modified DLI does not reduce GVL effect, but reduces the incidence of DLI-associated acute GVHD compared with prophylaxis for <6 weeks. This strategy will probably improve the safety and efficacy of modified DLI further.
Ligament reconstruction with tendon interposition arthroplasty for first carpometacarpal joint osteoarthritis
Authors: Yang Yong , Tien Huey Y. , Kumar Kannan K. , Chen Shanlin , Li Zhongzhe , Tian Wen , Tian Guanglei 
Published: January 2024

Background
Ligament reconstruction tendon interposition (LRTI) is the most commonly performed surgical procedure for first carpometacarpal joint osteoarthritis. The purpose of this study was to examine the radiographic and clinical outcomes of LRTI arthroplasty and document the clinical results based on metacarpal subsidence.

Methods
From January 2008 to January 2011, 19 patients (21 thumbs) underwent surgery for thumb carpometacarpal arthritis using ligament reconstruction tendon interposition arthroplasty with flexor carpi radialis (FCR) in Kleinert Kutz Hand Care Center of Louisville University, USA. The follow-up period was an average of 13.9 months. Pain, grip strength, tip pinch strength, range of motion, and radiographic measurements were recorded. Based on first metacarpal subsidence, the cases were classified in to mild, moderate, and severe. Clinical outcomes of the groups were evaluated and compared.

Results
Grip strength improved from 18.6 kg to 20.5 kg, and tip pinch strength increased from 4.4 kg to 4.5 kg after the surgery. Radial abduction and palmar abduction improved after surgery. Radial abduction increased from 55.7° to 60.6° and palmar abduction improved from 56.7° to 63.5° after the procedure. Visual analogue scores (VAS) were significantly reduced, from 6.6 to 0.5. Compared with the preoperative radiographs the first metacarpal had subsided about 54.6% of the arthroplasty space. The height of arthroplasty space and index of the arthroplasty space significantly decreased from 12.4 mm to 5.6 mm and from 0.27 to 0.12 respectively. Between the various groups (mild, moderate and severe metacarpal subsidence), there was no difference in grip strength, tip pinch strength, thumb range of motion, and VAS.

Conclusions
Ligament reconstruction tendon interposition arthroplasty resulted in excellent relief of pain and increase in range of motion. However, LRTI cannot maintain the arthroplasty space. Compared with the preoperative radiographs, the metacarpal subsided more than 50%. The amount of first metacarpal subsidence has no bearing on the results.
Oenanthe javanica extract increases immunoreactivities of antioxidant enzymes in the rat kidney
Authors: Hyun-Jin Tae , Park Joon Ha , Jeong-Hwi Cho , Kim In Hye , Ahn Ji Hyeon , Lee Jae Chul , Jong-Dai Kim , Jinseu Park , Choi Soo Young , Moo-Ho Won 
Published: January 2024

Background

Oenanthe javanica is an aquatic perennial herb originated from East Asia. Nowadays, the effects of Oenanthe javanica have been proven in various disease models. Studies regarding the antioxidant effect of Oenanthe javanica in the kidney are still unclear.

Methods
This study was therefore performed to investigate the effect of the Oenanthe javanica extract (OJE) in the rat kidney using immunohistochemistry for antioxidant enzymes, copper, zinc-superoxide dismutase (SOD1), manganese superoxide dismutase (SOD2), catalase (CAT) and glutathione peroxidase (GPx). Sprague-Dawley rats were randomly assigned to three groups: (1) normal diet fed-group (normal-group), (2) diet containing ascorbic acid (AA)-fed group (AAgroup) as a positive control, (3) diet containing OJE-fed group (OJE-group). AA and OJE were supplied during 28 days.

Results
The side-effects were not observed in all the groups. Immunoreactivities of SOD1, SOD2, CAT and GPx were easily detected in the distal tubules of the kidney, and their immunoreactivities in the AA- and OJE-groups were increased to about 1.4–1.5 times and 2 times, respectively, compared with those in the normal-group.

Conclusion
OJE significantly increased expressions of SOD1 & 2, CAT and GPx immunoreactivities in the distal tubules of the rat kidney, and this finding suggests that significant enhancements of endogenous enzymatic antioxidants by OJE treatment may be a legitimate strategy for decreasing oxidative stresses in the kidney.
Rethinking the German Tokens Uncovered in Amasya, Harşena Fortress and Maidens’ Palace Excavations
Authors: Naza Dönmez E. Emine 
Published: January 2024

Amasya, Harşena Fortress which rises from the banks of Yeşilırmak is comprised of three parts. From top to bottom, Harşena Fortress which is also called the upper fortress, the area in front of the rock-cut King Tombs which was called the Maidens’ Palace at the middle and the area called the Lower Palace, today’s Hatuniye District, at the bottom. The 2009-2010 excavations were done in an area north of Harşena Fortress’ cannon tower; excavation seasons of 2011-2013 were done in the area, front of the Royal Tombs in Maidens’ Palace area; excavations of 2017-2019 in Harşena Fortress were done in the area named as the Mosque Area, located at the entrance of the castle, South of the Watchtower.
Coin-like tokens which were known from the ancient-time have been utilized for many different reasons. Coins are metallic money which were minted by the political authority, that were used in the trade and had economic value. When the Roman numerical system has been abandoned for the Arabic numerals the usage of tokens for calculation in Europe has also been abandoned. After 16th century tokens were utilized as some type of medal. City of Nuremberg in Germany had been the main producer of tokens. After 17th century tokens got smaller and turned into the game chips.
To this day 8 German tokens were uncovered in the excavations in Amasya, Harşena Fortress and Maidens’ Palace. Amasya had always been a trade hub in the Ottoman period. The silk produced in the city had also been a developing trade endeavor in XIX century Amasya. The Germans who settled in the Amasya in this period made contributions to the silk production in the city. Especially this trade with the Germans can explain the German tokens found in the Amasya Fortress.
A Machine Learning Approach to Understanding the Physical Properties of Magnetic Flux Ropes in the Solar Wind at 1 au
Authors: Farooki Hameedullah , Abduallah Yasser , Noh Sung Jun , Kim Hyomin , Bizos George , Shin Youra , Wang Jason T. L. , Wang Haimin 
Published: January 2024

Abstract
Interplanetary magnetic flux ropes (MFRs) are commonly observed structures in the solar wind, categorized as magnetic clouds (MCs) and small-scale MFRs (SMFRs) depending on whether they are associated with coronal mass ejections. We apply machine learning to systematically compare SMFRs, MCs, and ambient solar wind plasma properties. We construct a data set of 3-minute averaged sequential data points of the solar wind’s instantaneous bulk fluid plasma properties using about 20 years of measurements from Wind. We label samples by the presence and type of MFRs containing them using a catalog based on Grad–Shafranov (GS) automated detection for SMFRs and NASA's catalog for MCs (with samples in neither labeled non-MFRs). We apply the random forest machine learning algorithm to find which categories can be more easily distinguished and by what features. MCs were distinguished from non-MFRs with an area under the receiver-operator curve (AUC) of 94% and SMFRs with an AUC of 89%, and had distinctive plasma properties. In contrast, while SMFRs were distinguished from non-MFRs with an AUC of 86%, this appears to rely solely on the 〈B〉 > 5 nT threshold applied by the GS catalog. The results indicate that SMFRs have virtually the same plasma properties as the ambient solar wind, unlike the distinct plasma regimes of MCs. We interpret our findings as additional evidence that most SMFRs at 1 au are generated within the solar wind. We also suggest that they should be considered a salient feature of the solar wind’s magnetic structure rather than transient events.
Categorization of Spatial and Temporal Ejecta Outcomes in Binary Systems Based on Variations of the Didymos System
Authors: Larson Jennifer N. , Fernandez Yanga , Sarid Gal 
Published: January 2024

Abstract
With the increasing number of binary asteroid systems being discovered, ejecta studies must expand from solely investigating single-body systems to modeling more complex multiple-body systems. For example, the Double Asteroid Redirection Test provides an opportunity to study the dynamics of a debris cloud around Didymos and Dimorphos, a near-Earth binary asteroid system. Here we simulate 72 variations on the Didymos system in order to categorize types of ejecta outcomes and analyze the influence of the varying system parameters on each outcome. We have varied five parameters: the system separation, the mass ratio between the two bodies, the impact location, the target-body shape, and the target-body rotation period. The resulting provenance maps of the final ejecta distributions were blindly sorted into five categories, while the resulting cumulative distribution functions (CDFs), describing the rate at which particles hit the surface, were blindly sorted into eight categories. We count the occurrences of the parameter values in each of the categories and apply a Cramer’s V statistical test to evaluate the significance of the association between each varied effect and the overall grouping of the provenance maps and CDFs. We conclude that more dominant effects, such as a small rotation period, produce notably similar ejecta distributions that result in being assigned to the same category. Less dominant effects, such as target-body location, are sorted into several categories due to the larger influence of varying dominant effects.
Prevalence of Nursing Students With Background Check Findings
Authors: Peters Christopher C. , Doering Jennifer J. 
Published: January 2024

Background:
Background checks (BGC) have been used in nursing education since the 2000s. Little is known about the prevalence of BGC among nursing students or how these students compare to the general population.

Method:
This retrospective study describes aggregated, de-identified BGC data from 2014–2019 in 16 large nursing programs in the United States. An independent samples t test was used to compare U.S. regional means and Federal Bureau of Investigation (FBI) regional arrest data.

Results:
The mean percentage of nursing student BGC with findings was 3.2% (minimum .00%, maximum 13.33%, SD 2.98%). The mean prevalence of BGC findings does not significantly differ among U.S. regions. There was no significant difference between BGC results in nursing students and regional FBI arrest data.

Conclusion:

Excluding students with BGC findings has not been studied but may represent a structural barrier to diversification of the nursing profession. Additional research linking BGC findings to public protection is required.

[
J Nurs Educ
. 2024;63(1):32–37.]
A Multisite Study of a Quality Improvement Teaching Strategy to Build Competency
Authors: Vottero Beth , Altmiller Gerry , Deal Belinda , Nurse-Clarke Natasha , Rosales Marc , Walker Danielle 
Published: January 2024

Background:
Quality improvement (QI) is an essential part of nursing education. Although there are robust examples of teaching strategies for QI, there is a distinct lack of research on effective strategies for teaching QI in nursing education.

Method:
This multisite study included students from six nursing programs. A treatment fidelity plan was developed and followed to ensure consistency for implementation of the study and data collection. A quasiexperimental, nonpaired, pre- and posttest study design was used to examine changes in student perspectives of QI after participating in a QI teaching strategy. Pre- and posttest questions were mapped to the American Association of Colleges of Nursing's Essentials subcompetency statements for QI.

Results:

A total of 254 pre- and 116 posttest responses were included for analysis. Significance (
p
= .05) was found at the beginning level within three questions.

Conclusion:

Findings from this study indicate beginning-level students can benefit from a competency-based QI learning activity.

[
J Nurs Educ
. 2024;63(1):38–42.]
Lung Epithelial Regnase-1 Dampens Local Immune Response but Does Not Worsen Susceptibility to Klebsiella pneumoniae
Authors: Lin Becky , Fan Li , Jackson Shaterra , Matunis Aidan R , Lou Dequan , Chen Kong , Trevejo-Nuñez Giraldina 
Published: January 2024

Abstract
Klebsiella pneumoniae (KP) presents a global health threat, leading to significant morbidity and mortality due to its multidrug-resistant profile and the limited availability of therapeutic options. To eliminate KP lung infection, the host initiates a robust inflammatory response. One of the host’s mechanisms for mitigating excessive inflammation involves the RNA-binding protein regnase-1 (Reg1, MCPIP1, or ZC3H12A). Reg1 has an RNA binding domain that recognizes stem-loop structures in the 3′ untranslated region of various proinflammatory transcripts, leading to mRNA decay. However, excessive suppression of inflammation by Reg1 results in suboptimal KP control. Reg1 deficiency within the nonhematopoietic compartment confers resistance to KP in the lung. Given that lung epithelium is crucial for KP resistance, we hypothesized that selective deletion of Reg1 in lung epithelial cells might enhance proinflammatory signals, leading to a better control of KP. Our transcriptomic analysis of epithelial cells in KP-infected wild-type mice revealed the presence of three distinct alveolar type 2 cell (AT2) subpopulations (conventional, inflammatory, and cycling) and enrichment of Reg1 in inflammatory AT2 cells. We conditionally deleted Reg1 in lung AT2 cells (ΔReg1), which amplified the local inflammatory response in the lung and increased macrophage cell numbers compared with controls. However, when ΔReg1 mice were subjected to KP infection, there were no significant differences in bacterial burden or survival compared with controls. These findings suggest that the local inflammatory response enhanced by Reg1 deletion in AT2 cells is insufficient to control KP infection.