bluuebunny/crossref_metadata_2025_split huggingface dataset:
Samenwerken in multidisciplinaire studententeams
Authors: Van Woerden Roosmarijn 
Published: February 2024

Docenten en onderwijsontwikkelaars in het hoger onderwijs incorporeren vaak multidisciplinair teamwerk in hun onderwijs om studenten voor te bereiden op het analyseren van complexe problemen in teamverband. De onderzoeksvraag die in dit artikel centraal staat, is: hoe kan een research-informed raamwerk van samenwerken bijdragen aan het vormgeven van onderwijs waarin studenten samenwerken en leren in multidisciplinaire studententeams? Eerst wordt een raamwerk van aspecten van samenwerking gepresenteerd gebaseerd op een systematic review van de literatuur over teamwerk. Dit raamwerk omvat externe invloeden op het team, teaminput, teamproces en teamoutput en subcategorieën daarvan. In de specifieke context van multidisciplinaire studententeams zijn bepaalde aspecten van samenwerking uit het raamwerk extra relevant, zoals de rol van de docent, complexiteit en onzekerheid van de taak, taak- en uitkomstafhankelijkheid, gebrek aan tijd voor teamontwikkeling, teamcompositie, het managen van diversiteit van disciplinaire achtergronden, integratie van inzichten en leiderschapsstructuren. Voor de ontwikkeling en uitvoering van onderwijs waarin studenten leren samen te werken in multidisciplinaire teams, zijn voor de relevante aspecten van samenwerking reflectievragen geformuleerd om te dienen als reflectietool voor docenten en onderwijsontwikkelaars.
Pengaruh Media Komunikasi Whatsapp terhadap Media Kebutuhan Afiliasi Mahasiswa STP Don Bosco Tomohon
Authors: Imbang Jearne Felix , Mentang Paulus Joseph 
Published: February 2024

The problem in this study is about the low intensity of student in the WhatsApp group. This affects the need for student affiliation. Many students who rarely open messages in the WhatsApp group. The purpose of this study was to determine the intensity of WhatsApp usage among students at STP Don Bosco Tomohon and to determine the effect of the group. This study used a quantitative method, with 100 students as a population and sample of 80 students. In the calculation, the researcher uses the slovin formula. The instrument used is a questionnaire. Respondents only put a checkmark on the answer they considered correct. Then the researcher will manage the collected data using the IBM SPSS 25 for windows application. Hypothesis Testing 1, the use of the WhatsApp communication medium at STP Don Bosco Tomohon is very good. Hypothesis 2, the need for student affiliation at STP Don Bosco Tomohon is high. The use of the WhatsApp communication medium has quite a 35% influence on the affiliation needs of STP Don Bosco Tomohon students, although the effect is less strong (low) and 65% is influenced by other factors. The intensity of the use of communication media Whatsapp at STP Don Bosco Tomohon is very good, with an R Count coefficient of 0.82, and an R Count coefficient on Student Affiliation Needs in the good category, with a value of 0.73. From the results of this study, based on the results of the correlation analysis that the WhatsApp communication media has a less strong and significant effect on the affiliate needs of STP Don Bosco Tomohon students.
PENERAPAN PEER COUNSELING UNTUK MENINGKATKAN KEAKRABAN DAN KERJASAMA REMAJA MASJID ARROYHAN SIHITANG PADANGSIDIMPUAN
Authors: Dela Vitria Larseman , Pardede Nurhasanah , Matondang Anas Munandar 
Published: February 2024

Konseling teman sebaya (Peers Counseling) dalam pengabdian masyarakat ini adalah program bimbingan yang dilakukan oleh remaja terhadap remaja yang lainnya. Remaja yang menjadi pembimbing sebelumnya diberikan latihan atau pembinaan oleh konselor. Remaja yang menjadi pembimbing berfungsi sebagai mentor atau tutor yang membantu remaja lain dalam memecahkan masalah yang dihadapinya, baik akademik maupun non-akademik. Pentingnya peer conseling ini bagi remaja adalah pencegahan terhadap konflik antar teman sebaya pada remaja.
Metode pelaksanaan kegiatan pengabdian masyarakat ini adalah dengan melaksanakan berbagai jenis layanan bimbingan dan konseling. Pengabdian masyarakat yang telah dilaksanakan pada remaja masjid Arroyyan Sihitang memberikan dampak dan manfaat yang positif. Salah satu teknik dalam konseling yang diberikan atau dilatihkan adalah teknik peer counseling atau konseling sebaya. Kegiatan konseling merupakan penyuluhan bantuan dalam mengatasi masalah pribadi, termasuk masalah emosional, perilaku, Pendidikan dan tahap kehidupan. Konselor menggunakan Teknik-teknik seperti mendengarkan secara aktif,bimbingan,nasihat, diskusi dan klarifikasi. Berdasarkan penjelasan tersebut, sangat jelas sekali bahwa peer counseling bagi remaja sangat dibutuhkan untuk mencegah hal-hal negatif yang dapat menjebak para remaja masa kini.

Kata kunci: Peer Counseling, Keakraban kerjasama, Remaja

Abstract
Peer counseling in community service is a guidance program carried out by teenagers towards other teenagers. Teenagers who become mentors are previously given training or coaching by counselors. Teenagers who become mentors function as mentors or tutors who help other teenagers in solving the problems they face, both academic and non-academic. The importance of peer counseling for teenagers is preventing conflict between peers in teenagers.
The method for implementing this community service activity is to carry out various types of guidance and counseling services. The community service that has been carried out among teenagers at the Arroyyan Sihitang mosque has had positive impacts and benefits. One of the counseling techniques that is given or trained is the peer counseling technique. Counseling activities provide assistance in overcoming personal problems, including emotional, behavioral, educational and life stage problems. Counselors use techniques such as active listening, guidance, advice, discussion and clarification. Based on this explanation, it is very clear that peer counseling for teenagers is really needed to prevent negative things that can trap today's teenagers.

Keywords: Peer Counseling, Friendly Collaboration, Teenagers
Penggunaan Instagram @umkla.official sebagai Sarana Branding dan Promosi Kampus
Authors: Prakosa Farid Aji , Permanasari Dian Eka 
Published: February 2024

Instagram dengan beragam kelebihannya telah menjadi sarana yang diperhitungkan dalam aktivitas branding dan promosi. Salah satu yang menjadi kelebihan adalah fitur-fitur di dalamnya yang memungkinkan pengguna untuk berinteraksi lebih dekat dengan audiens mereka. Potensi ini dimanfaatkan oleh perguruan tinggi khususnya swasta yang menggunakan Instagram untuk mempromosikan kegiatan mereka. Perguruan tinggi swasta lebih aktif dalam melakukan interaksi melalui media sosial (postingan, acara , following, dan berbagi) karena harus berusaha keras dalam mendapatkan pengakuan dan kredibilitas agar menjadi pilihan bagi masyarakat untuk menempuh pendidikan. Penelitian ini bertujuan untuk mengulas lebih lanjut bagaimana proses penggunaan Instagram @umkla.official sebagai sarana branding dan promosi kampus. Penelitian ini menggunakan metode pendekatan kualitatif dengan jenis penelitian deskriptif dan paradigma postpositivisme. Subyek dalam penelitian ini adalah tim pengelola media sosial dari Biro Humas UMKLA, sedangkan obyek pada penelitian ini adalah akun instagram @umkla.official. Dari penelitian ini diperoleh hasil bahwa Instagram menjadi media utama dalam memperkenalkan dan mempromosikan kampus Universitas Muhammadiyah Klaten (UMKLA) kepada masyarakat melalui jalur digital. Aktivitas branding yang dilakukan oleh UMKLA melalui akun Instagram @umkla.official merupakan aktivitas re-branding, dimana merubah citra sebelumnya sebagai kampus kesehatan dan kampus akuntansi menjadi kampus dengan beragam pilihan program studi dengan biaya kuliah dan biaya hidup yang terjangkau. Sedangkan aktivitas promosi yang dilakukan merupakan aktivitas promosi melalui media digital yang bersifat soft-selling, dimana promosi dilakukan tidak secara langsung menawarkan produk kepada target pasar, melainkan dengan menarik perhatian khalayak terlebih dahulu dengan konten unggahan yang menarik. Sehingga fokus konten unggahan bersifat informasi ringan, hiburan, leisure, serta interaktif.
UPAYA PEMBUKTIAN JAKSA PENUNTUT UMUM PADA KASUS TINDAK PIDANA PERSETUBUHAN ANAK (Study Dikejaksaaan Negeri Kabupaten Probolinggo)
Authors: Huda Samsul 
Published: February 2024

Abstrack

Evidence is an important thing in the criminal proceedings in the trial, in this study and its purpose, namely to find out the use of evidence by the Public Prosecutor in the process of criminal acts of child sexual intercourse, and to find out what the Public Prosecutor uses evidence to prove. prove the case of the crime of sexual intercourse against a minor in the case No. PDM 87/Kraks/Eku.2/08/2021.Krs. the formulation of the problem and the purpose of this study, the method used in this research is the empirical juridical method using the case approach method, namely legal research on regulations based on evidence based on article 184 of the Criminal Procedure Code Implementation in the Probolinggo District Prosecutor's Office, especially in the case No. PDM 87 / Kraks / Eku .2/08/2021.Krs. The results of the research in the preparation of this thesis, conclusions can be drawn, firstly the evidence used by the Prosecutor in the case of the crime of sexual intercourse against a child uses evidence based on the Criminal Procedure Code in 184, the second is the second from the Public Prosecutor in using Instructional tools Because the guidance tools are used to strengthen the Judge that he is wrong or not and the instructions as evidence are explained in accordance with other evidence.

Keywords: Efforts to Prove, Public Prosecutor, Child Intercourse
A New, Efficient and Environmentally Benign Protocol for the Synthesis of 1,5‐Benzodiazepines using Cerium(III) Chloride/Sodium Iodide Supported on Silica Gel
Authors: Sabitha Gowravaram , Reddy G. S. Kiran Kumar , Reddy K. Bhaskar , Reddy N. Mallikarjuna , Yadav J. S. 
Published: August 2004

AbstractA novel and green approach has been described for the synthesis of 2,3‐dihydro‐1H‐1,5‐benzodiazepines from o‐phenylenediamines and ketones using cerium(III) chloride/sodium iodide supported on silica gel under mild and heterogeneous conditions. The reactions are carried out at room temperature without using any organic solvent.
Mechanistic Insights into Anomalous Kinetic Behaviour in the Hydrogenation of a Substituted Nitrobenzene
Authors: LeBars Joel , Dini Stefano , Hawkins Joel M. , Blackmond Donna G. 
Published: August 2004

AbstractUnusual rate behaviour in the Pd‐catalyzed hydrogenation of 4‐nitroacetophenone is rationalized in terms of a combination of two reaction mechanisms, one which dominates at high substrate concentrations and one which dominates at the low surface coverage of substrate found at the end of the reaction. Kinetic modelling yields substrate binding constants consistent both with literature values for the first mechanism and with this proposal for the second mechanism. This behaviour may be general for the hydrogenation of bulky substituted nitrobenzene molecules containing functional groups which can interact with the Pd surface.
Asymmetric Hydrogenation of Quinolines Catalyzed by Iridium with Chiral Ferrocenyloxazoline Derived N,P Ligands
Authors: Lu Sheng‐Mei , Han Xiu‐Wen , Zhou Yong‐Gui 
Published: August 2004

AbstractChiral ferrocenyloxazoline derived N,P ligands are used in the iridium‐catalyzed asymmetric hydrogenation of quinolines, and up to 92% ee was obtained. The role of the planar chirality is also studied.
New Route to Biaryl Phosphanes with Axial Chirality as Ligands for Enantioselective Hydrogenations
Authors: Drießen‐Hölscher Birgit , Kralik Joachim , Agel Friederike , Steffens Christian , Hu Chunhua 
Published: August 2004

AbstractWe have found a modular route for the synthesis of Cl‐MeOBIPHEP ligands via the corresponding biphenol that allows us to introduce several substituents without the necessity to separate the enantiomers of each derivative. These new diphosphanes were used in the ruthenium‐catalyzed enantioselective hydrogenation of dimethyl itaconate with ee values up to 97%.
Nickel‐Catalyzed Regioselective Three Component Coupling Reaction of Alkyl Halides, Butadienes, and Ar‐M (M=MgX, ZnX)
Authors: Terao Jun , Nii Shinsuke , Chowdhury Firoz A. , Nakamura Akifumi , Kambe Nobuaki 
Published: August 2004

AbstractA new method for the regioselective three component cross‐coupling reaction of alkyl halides, 1,3‐butadienes, and aryl‐Grignard reagents has been developed by the use of a nickel catalyst. This reaction proceeds efficiently at 25 °C using (dppf)NiCl2 as a catalyst. Alkyl chlorides, bromides, and iodides can be used as suitable alkylating reagents. The reaction also proceeds when arylzinc halides are used instead of Grignard reagents. Competitive reactions of a mixture of primary, secondary, and tertiary alkyl bromides showed that the reactivities of the halides increase in the order primary<secondary<tertiary. A possible reaction pathway involving single electron transfer from a nickelate complex to alkyl halides is proposed.
Cross Metathesis Allowing the Conversion of a Ruthenium Indenylidene Complex into Grubbs' Catalyst
Authors: Dorta Reto , Kelly Roy A. , Nolan Steven P. 
Published: August 2004

AbstractThe active metathesis catalyst (PCy3)2Cl2Ru(3‐phenylinden‐1‐ylidene) (4) was obtained in high yield using a simple one‐pot procedure. The initial reaction of RuCl2(PPh3)3 with 1,1‐diphenyl‐2‐propyn‐1‐ol gave (PPh3)2Cl2Ru(3‐phenylinden‐1‐ylidene) (6). In situ exchange of PPh3 with PCy3 led to the isolation of 4 in>90% yield. Whereas complex 6 did not show any activity in the cross metathesis reaction with styrene, reaction of compound 4 with excess styrene gave Grubbs' catalyst, (PCy3)2Cl2RuC(H)Ph (1), dichloro(phenylmethylene)bis(tricyclohexylphosphane)ruthenium(II), in nearly quantitative yield. This two‐step procedure yielded complex 1 in 88% overall yield starting from inexpensive and commercially available materials. The widely used metathesis catalyst 1 was also obtained in good yield in one single step, that is, without isolation of compound 4, making this a simple and safe synthetic route to Grubbs' catalyst.
Enantioselective Hydrogenation of Trimethylindolenine in Ionic Liquids
Authors: Giernoth Ralf , Krumm Matthias S. 
Published: August 2004

AbstractThe enantioselective hydrogenation of trimethylindolenine (1) has been carried out in a variety of ionic liquids using an Ir‐XYLIPHOS catalyst. Compared to the reaction in conventional organic media, slightly higher temperatures (50 °C) are required, which is mainly due to the higher viscosities of the ionic media. Under these conditions we were able to identify three reaction media that gave ees comparable to the conventional process in toluene with greatly reduced reaction time (15 h as opposed to 23 h for 100% conversion; 91% conversion after 8 h). The sensitivity of the reaction system towards oxygen was also reduced significantly.
Chiral Amplification in Macromolecular Helicity Assisted by Noncovalent Interaction with Achiral Amines and Memory of the Helical Chirality
Authors: Morino Kazuhide , Watase Nobuyuki , Maeda Katsuhiro , Yashima Eiji 
Published: August 2004

AbstractPoly[(4‐carboxyphenyl)acetylene] (poly‐1) exhibits an intense induced circular dichroism (ICD) in the UV‐visible region upon complexation with excess (R)‐1‐(1‐naphthyl)ethylamine ((R)‐2), owing to the formation of a predominantly single‐handed helical conformation of the polymer backbone. In the presence of a small amount of (R)‐2, poly‐1 showed a very weak ICD due to the lack of a single‐handed helical conformation. However, we have found that the co‐addition of the excess bulky, achiral 1‐naphthylmethylamine (5) with a small amount of (R)‐2 caused a dramatic increase in the ICD magnitude, comparable to the full ICD induced by excess (R)‐2. This indicates that an almost single‐handed helix can be induced on poly‐1 upon complexation with a small amount of (R)‐2 assisted by achiral 5. Furthermore, the induced single‐handed helical poly‐1 could be successfully memorized by the replacement of (R)‐2 and 5 with achiral 2‐aminoethanol or n‐butylamine.
Extracellular matrix regulates endothelial functions through interaction of VEGFR‐3 and integrin α5β1
Authors: Zhang Xuefeng , Groopman Jerome E. , Wang Jian Feng 
Published: August 2004

AbstractEndothelium extracellular matrix (ECM) interactions can provide distinct spatial and molecular signals which control cellular proliferation, migration, and differentiation. Here, we investigated the role of fibronectin (FN), a major ECM protein, on the functions of lymphatic endothelial cells (LEC). We observed that FN, the ligand for integrin α5β1, selectively promoted the growth of LEC as compared with vitronectin (VN) in the presence of the ligand for vascular endothelial growth factor receptor 3 [VEGFR‐3 (VEGF‐C156S)]. Upon investigating the mechanisms whereby ECM components regulate VEGFR‐3 signaling, we found that FN transactivated VEGFR‐3 and significantly enhanced the phosphorylation of VEGFR‐3 induced by VEGF‐C156S as compared to VN. An enhanced association of the integrin subunit α5 or β1 with VEGFR‐3, after stimulation with VEGF‐C156S, was observed by co‐immunoprecipitation. While blockade of integrin α5β1 inhibited the VEGF‐C156S‐induced phosphorylation of VEGFR‐3, no similar effect was obtained by blocking integrin αvβ3. FN also protected the endothelial cells from serum deprivation‐induced apoptosis. Moreover, while the specific PI3 kinase inhibitor, LY294002, abolished this FN‐mediated cell survival, the MAPK kinase inhibitor, PD98059, had no significant effect. Furthermore, a dominant‐negative mutant of VEGFR‐3 (G857R) reduced VEGF‐C156S or FN‐mediated cell survival, as well as the activities of PI3 kinase/Akt. Our results indicate that integrin α5β1 participates in the activation of both VEGFR‐3 and its downstream PI3 kinase/Akt signaling pathway, which is essential for FN‐mediated lymphatic endothelial cell survival and proliferation. © 2005 Wiley‐Liss, Inc.
Increased expression of geminin stimulates the growth of mammary epithelial cells and is a frequent event in human tumors
Authors: Montanari Micaela , Boninsegna Alma , Faraglia Beatrice , Coco Claudio , Giordano Antonio , Cittadini Achille , Sgambato Alessandro 
Published: August 2004

AbstractGeminin is a potent inhibitor of origin assembly and re‐replication in multicellular eukaryotes and is a negative regulator of DNA replication during the cell cycle. Thus, it was proposed as an inhibitor of cell proliferation and as a potential tumor suppressor gene. However, the protein was found specifically expressed in proliferating lymphocytes and epithelial cells and up‐regulated in several malignancies. Therefore, geminin is now regarded as an oncogene but its role in tumor development remains unknown. In this study, we evaluated by Western blot analysis the expression of geminin in a series of human cancer cell lines of various histogenetic origin and in a series of human primary colon, rectal, and breast cancers. Expression of geminin was variable in different cell lines and not related to the expression level of the corresponding mRNA. Moreover, geminin was expressed at higher level in 56% and 58% of colon and rectal cancers, respectively, compared with the corresponding adjacent normal mucosa. A high expression of geminin was also detected by immunohistochemistry in 60% of human primary breast cancers. We also transfected a full‐length geminin cDNA in a human non‐tumorigenic and a cancer breast cell lines and obtained derivatives expressing high levels of the protein. Geminin overexpression stimulated cell cycle progression and proliferation in both normal and cancer cells and increased the anchorage—independent growth of breast cancer cells. These results demonstrate that expression of geminin is frequently deregulated in tumor cells and might play an important role in the regulation of cell growth in both normal and malignant cells. © 2005 Wiley‐Liss, Inc.
Upregulation of TNF‐α‐induced ICAM‐1 surface expression by adenylate cyclase‐dependent pathway in human endothelial cells
Authors: Bernot Denis , Peiretti Franck , Canault Matthias , Juhan‐Vague Irène , Nalbone Gilles 
Published: August 2004

AbstractThe level of adhesion molecules expressed at the endothelial cell surface is critical in the control of inflammation. Adenylate cyclase (AC) activity allowing cyclic adenosine monophosphate (cAMP) production can modulate the inflammatory process. We investigated the AC‐dependent modulation of ICAM‐1 surface expression in human umbilical venous endothelial cells (HUVEC). Pretreatment of HUVEC with forskolin significantly upregulated tumor necrosis factor alpha (TNF‐α)‐ and interleukin‐1 alpha (IL1‐α)‐induced ICAM‐1 surface expression exclusively after a prolonged time of incubation with forskolin (at least 7–8 h). A poorly metabolizable analog of cAMP, dibutyryl‐cAMP, mimicked forskolin effect on ICAM‐1 surface expression. Protein kinase A (PKA) inhibitor H89 prevented forskolin effect on ICAM‐1 surface expression. Upregulation of ICAM‐1 surface level occurred through the increase in its mRNA levels and also to a subsequent activation of ICAM‐1 intracellular trafficking towards cell surface. Stimulation by agonists of β‐adrenergic receptors did not alter the TNF‐α‐induced ICAM‐1 surface expression. Pretreatment of HUVEC with pertussis toxin, which is known to activate AC through Giα inhibition, upregulated mRNA levels and surface expression of ICAM‐1 induced by TNF‐α. This effect was serum‐dependent, since ICAM‐1 expression was no more upregulated by pertussis toxin in cells cultured in 1% instead of 20% serum‐enriched medium. However, forskolin treatment of HUVEC did not modify their overall adhesive properties. In conclusion, a persistent cAMP level elevation activating PKA is able to enhance ICAM‐1 expression at the cell surface of endothelial cells placed under pro‐inflammatory conditions. Combination of activation of gene transcription and membrane targeting may account for this augmentation. © 2004 Wiley‐Liss, Inc.
Direct analysis for performance‐based design of steel and composite structures
Authors: Richard Liew J Y , Chen H 
Published: August 2004

AbstractThere is a worldwide trend for modern design specifications to depart from prescriptive methods and to move towards performance‐based design approaches. The gradual shift towards performance‐based design increases the need to have efficient and robust direct analysis methods to assess the global performance of structures. Considerable research has been conducted on nonlinear analysis methods in steel and composite members and frames over the last decade. Whilst their use has been limited to the investigation of structural failure and detailed member behaviour, the emergence of high‐speed computers and pre‐ and post‐processing graphic software has led to an increased reliance of direct analysis for designing large‐scale structural systems. This paper reviews some of the principles related to the use of direct analysis for performance‐based design of steel and composite frames, and discusses the issues that are essential for implementation in practice. Illustrative examples are given to show the benefits of using direct analysis for evaluating the overall performance of structural systems in terms of serviceability, ultimate strength and also under exceptional conditions (accidental design situations).
Noncovalent intermolecular energetics: RDX crystal
Authors: Politzer Peter , Ma Yuguang 
Published: August 2004

AbstractA methodology for using electronic densities to determine electrostatic, polarization, and total energies of noncovalent interactions is summarized and applied to two key molecular pair combinations in the crystal lattice of RDX (hexahydro‐1,3,5‐trinitro‐s‐triazine). It is found that the total interaction energies can be well approximated as purely electrostatic between RDX molecules in the chair–AAE conformation. However, Mulliken and CHelpG point‐charge models are not adequate for reproducing these energies. © 2004 Wiley Periodicals, Inc. Int J Quantum Chem, 2004