bluuebunny/crossref_metadata_2025_split huggingface dataset:
Effects of Chinese herbal medicines mixture on antioxidant, immunity and disease resistance against infectious hematopoietic necrosis virus infection in rainbow trout (Oncorhynchus mykiss)
Authors: Wang Qi , Huang Jinqiang , Li Yongjuan , Wu Shenji , Zhao Lu , Pan Yucai , Kang Yujun , Liu Zhe 
Published: October 2023

Abstract
Chinese herbal medicine (CHM) has attracted widespread attention due to its natural, non-toxic, and low side-effect properties. Furthermore, Chinese herbal medicines mixture (CHMM) is often considered to have more beneficial effects than a single CHM. The present study was conducted to evaluate the effects of CHMM on antioxidant, immunity and disease resistance against infectious hematopoietic necrosis virus (IHNV) in rainbow trout (Oncorhynchus mykiss). The results showed that the total superoxide dismutase (T-SOD), catalase (CAT), acid phosphatase (ACP), alkaline phosphatase (AKP) activities of rainbow trout were significantly enhanced (P < 0.05) and the malondialdehyde (MDA) content was significantly reduced (P < 0.05) after feeding with CHMM. Meanwhile, the expression of immune and antiviral related genes (NF-KB, TNF-α, IL-1β, IL-8, MDA5, LGP2, IRF-3, IRF-7, IFN1, JAK1, STAT1 TLR3, TLR7, MYD88 and TGFβ) of rainbow trout were down-regulated after feeding with CHMM. After infected IHNV, the results showed that the all CHMM treatment groups increased Antioxidant and immune-related enzyme activities (T-SOD, CAT, ACP, AKP), while significantly reduced (P < 0.05) the MDA content. The expression of NF-KB, TNF-α, IL-1β, IL-8, MDA5, LGP2, IRF-3, IRF-7, IFN1, JAK1, STAT1, TLR3, TLR7, MYD88 and TGFβ were up-regulated by CHMM. In summary, based on the current experimental conditions, the CHMM has been discovered to effectively improve the antioxidant, immune, and disease resistance capacities of rainbow trout and the recommended dosage of CHMM supplementation for rainbow trout is approximately 30 g/kg.
A bi-directional Mendelian randomization study of the sarcopenia-related traits and Primary gonarthrosis
Authors: Wang Zhangzheng , Yan Hongsong , Yu Yifan , Lian Mo , hao Ge , Luo Weidong 
Published: October 2023

Abstract
Background: Sarcopenia and primary gonarthrosis are common prevalent diseases in elderly people. Previous studies have reported a close association between the two, but causation was prone to confounding factors. A more robust research approach is urgently required to investigate the causal relationship between sarcopenia and primary gonarthrosis.
Methods: The bi-directional two-sample Mendelian randomization (MR) analyses was carried out to explore causal inference between sarcopenia-related traits and primary gonarthrosis. The open GWAS database established by the MRC Integrated Epidemiology Unit (IEU) and FinnGen database provided the summary-level data used in this investigation. The GWAS summary data for appendicular lean mass (ALM, n=450,243), low hand grip strength(n=256,523), hand grip strength (left)(n=461,089), hand grip strength (right)(n=461,089) and usual walking pace (n=459,915) were used as sarcopenia-related traits. The GWAS summary data for knee osteoarthritis (KOA, n=403,124), primary gonarthrosis (n=285,550) and primary gonarthrosis, surgery (n=356,322) were used as phenotypes for primary gonarthrosis. The inverse-variance weighted (IVW) approach was used to obtain MR estimates, and various sensitivity analysis was also performed.
Results: Increased hand grip strength (right) reduced the risk of gonarthrosis surgery (OR = 0.702; p = 0.0308). Furthermore, the risk of knee diseases and knee surgery was reduced by increasing walking pace. Correspondingly, gonarthrosis significantly reduces usual walking pace. Unexpectedly, our findings support a positive association between ALM and primary gonarthrosis. But it turns to less significant (p > 0.05) after conducting multivariable Mendelian randomization (MVMR) analyses combining Body mass index (BMI) and height.
Conclusion: Sarcopenia-related traits (hand-grip strength and walking pace) may lead to the occurrence and progression of primary gonarthrosis. But there is insufficient evidence that gonarthrosis causes sarcopenia.
The green synthesis of highly fluorescent carbon quantum dots through microwave heating using honey for optical detection of Ibuprofen.
Authors: Gholipour Arsalan , Hosseini Morteza 
Published: October 2023

Abstract
In the current research, a green strategy to synthesis carbon quantum dots (CQDs) with a quantum yield (QY) of nearly 19% has been successfully established. Subsequently, the different features of as-prepared CQDs was evaluated by detailed analyses including high resolution transmission electron microscopy (HRTEM), Fourier transform infrared spectroscopy (FTIR), X-ray photoelectron spectroscopy (XPS), and photoluminescence (PL) spectra. The different analyses proved that the CQDs obtained here had various advantages such as quasi-spherical shape, different functional groups, and great optical features. Additionally, the as-synthesized CQDs were employed for optical detection of Ibuprofen based on the interactions between Ibuprofen and diverse functional groups such as -OH, C-H, and N-H that existed on the surface of CQDs, resulting in aggregations that facilitate to quench the fluorescence (FL) of CQDs. Furthermore, the results indicated that the as-prepared CQDs can detect Ibuprofen in a linear range of 0 to 100 µM with a limit of detection (LOD) of 1.18 µM (signal to noise ratio of 3).
Communication matters - Sensitivity in fairness evaluations across wealth inequality expressions and levels
Authors: Oppel Annalena 
Published: October 2023

Abstract

This paper seeks to understand whether the way in which inequality is communicated through measurements influences individuals’ fairness perceptions regarding wealth inequality. It begins from the premise that prominent measures of inequality, such as the Gini coefficient, fall short of providing an intuitive understanding of inequality for most people. Following approaches in the behavioural economics domain, the paper explores the effects of four different presentations of inequality in a survey experiment. In this way it aims to see whether individuals’ fairness evaluations change across different levels of inequality. To do so, it introduces three different inequality scenarios, respectively corresponding to Gini coefficients of 32.8, 46.8, and 60.3. The scenarios are presented using different expressions: large-stake and small-stake units for absolute expressions, and percentages and multiples for relative expressions. The results point to a notable difference in fairness evaluations based on whether respondents are presented with absolute versus relative expressions of inequality: absolute expressions lead to a larger decline in fairness evaluations for higher levels of inequality. More broadly, the paper’s contribution highlights the importance of ‘intuitive’ measures of political matters such as wealth inequality. It further indicates that this may be vital in highly unequal countries such as South Africa.. This concerns public and policy discourses alike. The paper suggests avenues for further exploration to bring more nuance and context to the patterns observed.
Unusual reason of nutcracker syndrome of the renal vein: a case report
Authors: Ileri Sara Yavuz 
Published: October 2023

Abstract
52-year-old female patient who presented with painless hematuria, was admitted to the urology outpatient clinic. After the initial ultrasound examination, she underwent cystoscopy. Urine cytology and pathology were benign. So, she referred to the nephrology clinic. Her renal functions were normal, and she had no proteinuria. Urinary sediment revealed 10-15 isomorphic erythrocytes. Diagnosis of glomerulonephritis was excluded. According to her medical history and records it was learned that she had undergone Whipple operation three years ago. Considering surgery history, doppler ultrasound was planned because of the possibility of renal vein compression. Renal vein doppler ultrasound revealed that the left renal vein diameter was 9.5 mm before the superior mesenteric artery, and it was 1.8 mm after the artery. Nutcracker syndrome of the renal vein was diagnosed. Since the kidney functions were normal and the patient was normotensive, follow-up was planned at 6- month intervals. Nutcracker syndrome is a rare syndrome that occurs when the renal vein is compressed in various anatomical regions, most commonly between the aorta and the superior mesenteric artery. It be produced by pancreatic neoplasms, para-aortic lymphadenopathy, retroperitoneal tumors, or strangulating fibrolymphatic tissue between the superior mesenteric artery and the aorta. However, there is no case reported in the literature because of previous Whipple surgery. By documenting this case, we aimed to remind that taking a good anamnesis and making relevant imaging methods, may attribute to diagnosis rare cases and save time for clinicians especially in cases with a grave result such as nephrectomy unless they diagnosed.
The Outcome of Central Nervous System Hemangioblastomas in Von Hippel-Lindau (VHL) Disease Treated with Belzutifan: A Single-Institution Retrospective Experience
Authors: Zamarud Aroosa , Marianayagam Neelan J. , Park David J. , Yener Ulas , Yoo Kelly H. , Meola Antonio , Chang Steven D. 
Published: October 2023

Abstract
Purpose:
Belzutifan is a Hypoxia Inducible Factor 2-alpha inhibitor approved in 2021 by the FDA for the treatment of renal cell carcinoma (RCC) in patients with Von-Hippel Landau (VHL) disease. These patients can also present with central nervous system (CNS) hemangioblastomas (HBs). We aim to study the effectiveness and adverse effects of belzutifan for CNS HBs, by reporting our preliminary institutional experience.
Methods:
We present a series of VHL patients with CNS HBs undergoing treatment with belzutifan for RCC. All the included patients met the RECIST inclusion criteria. The clinical and radiological outcome measures included: Objective response rate (ORR), time-to-response (TTR), adverse events (AE), and patient response. Patient response was classified as partial response (PR), complete response (CR), progressive disease (PD), or stable disease (SD).
Results:
Seven patients with 25 HBs were included in our study. A Belzutifan dose of 120 mg/day PO was administered for a median of 13 months (range 10–17). Median follow up time was 15 months (range 10–24). An ORR of 71% was observed. The median TTR was 5 months (range: 1–10). None of the patients showed CR, while 5 patients (71.4%) showed PR and 2 (28.5%) showed SD. Among patients with SD the maximum tumor response was 20% [increase/decrease] of the lesion diameter. All the patients experienced decreased hemoglobin concentration, fatigue, and dizziness. None of the patients experienced severe anemia (grade 3–4 CTCAE).
Conclusion:
Belzutifan appears to be an effective and safe treatment for CNS hemangioblastoma in VHL patients. Further clinical trials to assess the long-term effectiveness of the medication are required
Seismic Analysis of Unreinforced Stone Masonry Buildings with Mud Mortar
Authors: Adhikari Pradip , Chaulagain Hemchandra 
Published: October 2023

Abstract

Nepal is situated in a highly seismically active Himalayan region where most residential buildings are constructed using masonry. Due to the local availability of stones and masons, unreinforced stone masonry buildings with mud mortar are common in Nepal's mountainous and hilly regions. Past seismic events in and around Nepal have revealed that these structures are highly vulnerable during earthquakes. However, much of the research in the region has primarily focused on reinforced concrete building structures. Therefore, this study aims to assess the structural behavior and failure mechanisms during earthquakes. Local materials were collected, and samples of structural walls were prepared in the laboratory to characterize material properties. Experiments were conducted to study the failure patterns of stone masonry walls. The performance of the studied buildings was analytically evaluated using linear time history analysis. The probability of damage level in different earthquakes were presented through fragility curves. The results from the analysis indicated that all the studied masonry buildings are vulnerable in moderate level of ground shaking.
Emergence and genomic characterization of Klebsiella pneumoniae and Escherichia coli harboring tet(X4) disseminated by Black kites (Milvus migrans)
Authors: Mansoor Muhammad Hassan , Lu Xiaoyu , Voksepp Hanna , Sattar Amna , Humak Farwa , Ali Jabir , Li Ruichao , Bonnedahl Jonas , Mohsin Mashkoor 
Published: October 2023

Abstract
The emergence of plasmid-mediated tigecycline resistance gene tet(X4) among clinically relevant bacteria has raised serious concerns since tigecycline is considered as last-resort drug against serious infections caused by multidrug-resistant bacteria. We herein focused on the isolation and molecular characterization of tet(X4)-positive Klebsiella pneumoniae (K. pneumoniae) and Escherichia coli (E. coli) in wild bird populations with anthropogenic interaction in Faisalabad, Pakistan. A total of 150 birds including black kites (Milvus migrans) and house crows (Corvus splendens) were screened for the presence of tigecycline resistance K. pneumoniaeand E. coli. We found two K. pneumoniae and one E. coliisolate carrying tet(X4) originated from black kites. A combination of short- and long-read sequencing strategy showed that tet(X4) was located on a broad host range IncFII plasmid family inK. pneumoniae isolates whereas on an IncFII-IncFIB hybrid plasmid in E. coli. We also found an integrative and conjugative element ICEKp2 in K. pneumoniae isolate KP8336. The combination of tet(X4) and a known virulence associated ICEKp2 in a wild bird with significant human interaction is particularly worrisome. We demonstrated the first description of tet(X4) gene in the WHO critical-priority pathogen K. pneumoniae among wild birds with known anthropogenic interaction and dispersal potential. The potential risk of global transmission of tet(X4)-positive K. pneumoniae and E. coli warrant comprehensive evaluation.
Effect of Nickel doping on Cobalt Oxide Nanoparticles for energy storage applications
Authors: Karthikeyan A. , Mariappan R. , Krishnamoorthy E. , Bakkiyaraj R. 
Published: October 2023

Abstract
We present a comprehensive study on the utilization of Ni-doped Co3O4 nanoparticles for energy storage applications, particularly in supercapacitors. X-ray diffraction analysis confirms the structural integrity and phase purity of the samples, exhibiting the characteristic peaks of the cubic spinel structure X-ray photoelectron spectroscopy confirms the presence of Co, Ni, and O elements, with different valence states observed. Scanning electron microscope images reveal irregular nano-flakes with increased particle size and reduced porosity as Ni doping concentration rises. Electrochemical analysis, including cyclic voltammetry and galvanostatic charge-discharge tests, demonstrates promising performance. Specifically, the 3 wt% Ni-doped Co3O4 sample exhibits a maximum specific capacitance of 299 F/g at a scan rate of 5 mV/s. The GCD profile of all the three Ni doped Co3O4 Nps were carried out. All of them revealed quasi triangular charge-discharge curve that are due to both pseudo capacitive and electric double layer process. Moreover, the 3% Ni-doped Co3O4 nanoparticles demonstrate a maximum specific capacitance of 347 F/g at a scan rate of 1.5 A/g. Additionally, the 5% Ni-doped Co3O4 nanoparticles exhibit an impressive capacity retention of 92.87% even after 1500 cycles. Our findings indicate that appropriate Ni doping on Co3O4 nanoparticles enhances their electrochemical performance, great potential for supercapacitor applications.
A novel approach for anaerobic threshold heart rate prediction using whale optimization algorithm based random forest algorithm
Authors: Li Pei zheng , Xie Cong , Guo Xin 
Published: October 2023

Abstract
Anaerobic threshold (AT) is the critical point at which the energy system produces different energy supply patterns during exercise. At present, the measurement of AT is obtained through cardiopulmonary exercise testing (CPET). The heart rate at which an individual enters the anaerobic threshold during cardiopulmonary exercise testing is referred to as the anaerobic threshold heart rate. When using sports prescription or exercise plan as a means to improve health status or quality of life, it is necessary to determine the specific exercise intensity according to the individual's anaerobic threshold heart rate. This paper aims to using whale optimization algorithm based random forest algorithm (WOA-RF) to predict the anaerobic threshold heart rate of individuals by collecting the basic physical characteristics, heart rate and load in CPET. Data that are easy to collect for daily measurement are selected: age, gender, height, weight, initial heart rate, initial load, relative heart rate increment at 30% maximum load, relative heart rate increment at 50% maximum load, relative heart rate increment at 70% maximum load, maximum heart rate, and maximum load.In the result of predicted value: RMSE=7.9445, MAE=6.4206, R2=0.7152. We consider the feasibility of prediction anaerobic threshold heart rate by WOA-RF machine learning algorithm to be acceptable.
The Impact of Intimate Partner Violence on the Mental and Physical Health of Sexual and Gender Minorities: A Comprehensive Review of Quantitative Research
Authors: Rodrigues Mariana , Neaman Annaliese , Ditzer Julia , Talmon Anat 
Published: October 2023

Abstract
Purpose
The aim of this review is to investigate the mental and physical health outcomes of Intimate Partner Violence (IPV) victimization among Sexual and Gender Minority (SGM) individuals. This study adopts an intersectional lens to address an existing gap in research concerning IPV outcomes among SGM populations.
Methods
A systematic review was conducted through PubMed, APA PsycInfo and APA PsycNet utilizing specific keywords. Inclusion criteria included peer-reviewed publications from the last 10 years, and quantitative studies specifically assessing IPV outcomes among SGM individuals. A total of 23 studies meeting these criteria were included in the review.
Results
Our results show significant associations between IPV victimization and adverse health and mental health outcomes, including posttraumatic stress disorder, depression, anxiety, suicidal ideation and attempts, substance use, and risky sexual behaviors among SGM individuals.
Conclusions
IPV victimization poses unique mental and physical health risks for SGM populations. Our findings highlight the need for comprehensive, tailored intervention and prevention efforts that consider the intersectionality of multiple minoritized identities in the context of IPV victimization.
An integrated transportation-inventory model with carbon emission and its impact on the total cost bounds
Authors: Hisam M.S.M. , Juman Z.A.M.S. , Hoque M.A. , Daundasekera W.B. , Akilbasha A. 
Published: October 2023

Abstract
In the literature amathematical model had been presented to transport a homogeneous product from multi-source to multi-destination, to meet the demand of each destination at a time. Both the demand and the supply were assumed to vary within a certain range. The total cost bounds of transportation were obtained by using the LINGO solver. Here we emphasize that carbon emission, and inventory cost of a product during transportation and in destinations is an important factors in deciding these cost bounds. Besides, consideration of some realistic constraints such as transport vehicle capacity and transport load limitation on a given route is also an important factor. Based on this notion, we extend the original model to include these carbon emission and inventory costs along with some realistic constraints and use the same solver to find out the total cost bounds. Numerical studies demonstrate that such an integration of carbon emission, inventory and transportation costs changes the total cost bounds reasonably. The conclusion is drawn by discussing the limitations of the current model and highlighting the scope for further research.
MSC Classification Code: 90B06, 90B25, 90B50
Sıyırıcı Olarak Kullanılan Polimer Boncuklarının ve Farklı Havalandırma Yoğunluklarının Membran Tıkanması Üzerine Sinerjistik Etkisi
Authors: YAVUZTÜRK GÜL Bahar , KOYUNCU İsmail 
Published: October 2023

Membran biyoreaktörlerin (MBR) işletimi sırasında karşılaşılan en önemli problemlerden biri biyotıkanma sorunudur. Bu makalede düşük ve yüksek havalandırma yoğunluğunun (150 L/s ve 350 L/s) ve boncuk kullanımının membran biyotıkanması üzerindeki sinerjistik etkisinin belirlenmesi amaçlanmıştır. Bu sorunun çözümüne yönelik olarak, öncelikle biyofilm sıyırıcı etkisinden faydalanmak amacıyla polimer boncukların üretimi ve optimizasyonu yapılmıştır. Seçilen boncuklar ile yüksek ve düşük iki farklı havalandırma yoğunluğunda üç reaktör işletmesi gerçekleştirilmiştir.
Optimizasyon sonuçlarına göre %12,5 polivinil alkol (PVA) ve %1 sodyum aljinat (S.A) kullanılarak hazırlanan, 2 saat süre ile %5,5 borik asit-%2 CaCl2 karışımında ve 15 dakika süre ile 0,3 M fosfat çözeltisi içerisinde bekletilen boncuklar seçilmiştir. 350 L/s ile yapılan 1. MBR işletmesi sonucunda transmembran basıncı (TMP) 280 mbar olarak kaydedilirken havalandırmanın yoğunluğunun yarıya düşürüldüğü ikinci işletme sonunda TMP 440 mbar’a yükselmiştir. Bu sonuçlara göre membran biyotıkanması, düşük havalandırma yoğunluğunda yüksek havalandırma yoğunluğuna göre %57 oranında artış göstermiştir. Kimyasal yıkama sonrası yüksek havalandırma koşulları ile 3. kez işletilen MBR’da işletme sonunda maksimum TMP değeri 350 mbar olarak kaydedilmiştir. Yüksek havalandırma koşullarındaki iki işletme karşılaştırıldığında 1. işletmeye göre 3. işletme sonunda TMP değerinde gözlenen %25 artış membran modülünde meydana gelen geri dönüşümsüz tıkanmanın bir sonucu olarak değerlendirilmiştir. Bu nedenle polimer boncukların yüksek olmayan havalandırma koşulunda da ilave membran sıyırıcı özellikleriyle biyofilm önleme adına ek olumlu etki ortaya koyması kritik öneme sahiptir. Havalandırma koşulları ve polimer boncukların ortak kullanımı ve tasarlanan işletme koşullarına göre optimizasyonu biyotıkanmanın kontrol altına alınması ve havalandırma maliyetlerinde iyileşmeye neden olacaktır.