bluuebunny/crossref_metadata_2025_split huggingface dataset:
Plasma-activated water regulated transcriptome gene expression leading to high germination and growth of mung beans
Authors: Chou Yu-Jou , Ting Yuwen 
Published: December 2023

Abstract
Background
Plasma-activated water (PAW) is a solution created by exposing water to cold atmospheric plasma discharge, resulting in a biocidal agent with unique biochemical properties attributed to highly reactive oxygen and nitrogen species (RONS). Plasma-activated water (PAW) has been the subject of research for its potential in promoting seed germination. While it has shown promising results, the exact mechanism by which PAW promotes seed growth remains unclear. This study aims to investigate the role of PAW in promoting mung bean germination, including its effects on vitality improvement and the triggering of plant stress responses to promote crop growth. Through the utilization of next-generation sequencing, we aim to explore the interaction between the properties of PAW and gene expression in mung beans. By deciphering the nature of PAW and analyzing gene expression patterns, we hope to uncover the underlying mechanisms that govern their interaction.

Results
The results revealed that nitrogen plasma-activated water (NPAW) treatment improves the vitality and hypocotyl length of mung beans and leads to a good overall growth state. Moreover, we identified numerous differentially expressed genes (DEGs), including genes related to stress responses, growth regulation, and metabolic processes, that were upregulated or downregulated in response to PAW treatment. As a result of APAW treatment, 168 genes were upregulated and 90 genes were downregulated. Furthermore, 179 genes were upregulated in the NPAW compared to 125 genes that were downregulated in the control group. Gene expression analysis revealed involvement in stress signaling and metabolic processes.

Conclusions
PAW treatment can promote crop growth and serve as a reference for other seeds. This research provides insights into the regulatory mechanisms and benefits of PAW in sustainable agriculture.

Graphical Abstract
HIV treatment cascade among female sex workers in Ethiopia: Assessment against the UNAIDS 90-90-90 targets
Authors: Abdella Saro , Demissie Meaza , Worku Alemayehu , Dheresa Merga , Berhane Yemane 
Published: December 2023

Background
HIV treatment cascades for HIV-positive female sex workers (FSWs) have been challenged by the overlapping stigma and discrimination associated with both their sex work and HIV status. This study aims to assess the proportion of HIV-positive FSWs who access care and treatment in Ethiopia.

Method
A cross-sectional study with a respondent-driven sampling technique was used to enroll 6,085 female sex workers from January to June 2020. Interviews were conducted to assess the FSWs’ HIV status awareness and access to ART. A blood sample was drawn to determine the current HIV status and viral load level. Logistic regression was run to identify factors associated with FSWs’ HIV status awareness.

Results
Of the total 1140 HIV-positive FSWs, 50.38% knew they were HIV positive; 92.88% of those who knew their status were on ART, and 91.68% of those on ART had attained viral suppression of less than 1000 copies per milliliter. The adjusted odds of knowing HIV status was 3.20 (95% CI; 2.00, 5.13) among those aged 35 years and older, 1.81 (95% CI; 1.05, 3.12) among widowed, and 1.73 (95% CI; 1.28, 2.32) in those who did not perceive the risk of HIV acquisition.

Conclusion
Only about half of HIV-positive FSWs knew they were HIV positive. More than 90% of those who knew their status were put on ART and achieved viral suppression. The weakest point in achieving HIV control among FSWs is the identification of those living with HIV.
Determinants of human papillomavirus vaccine hesitancy among Lebanese parents
Authors: Zakhour Ramia , Tamim Hani , Faytrouni Farah , Makki Maha , Hojeij Rayan , Charafeddine Lama 
Published: December 2023

Introduction
Human papillomavirus (HPV) is the most common sexually transmitted infection. HPV is responsible for cancer of cervix uteri. Despite its safety and immunogenicity, HPV vaccine hesitancy is one of the most challenging topics that pediatricians face.

Methods
We aimed to describe the impact of knowledge, attitude, and practice towards vaccines in general, on practice related to HPV vaccination in Lebanon. A questionnaire addressed to parents of students (3–18 years of age) was distributed in 2 public and 2 private schools randomly selected from the greater Beirut area during the school year 2017–2018. Questionnaires covered knowledge, attitude, and practices of vaccination in general and HPV vaccine in particular.

Results
Out of 400 distributed questionnaires, 306 (76.5%) were returned. Of the 185 parents aware of HPV vaccine, 60% hadn’t given or were not planning to give the HPV vaccine to their children. Of parents not in favor of HPV vaccine, 7.5 thought that vaccines aren’t necessary versus none among those in favor of HPV vaccine(p = 0.02). Thirteen percent of those not in favor of HPV vaccine thought that vaccines are not safe versus 2.7% in the group in favor (p = 0.02). An effect of gender on vaccine acceptance was noted: mothers vs fathers and daughters vs sons. Lack of recommendation by pediatricians and the thought that too little is known about the vaccine were the most selected reasons for parents not wanting to vaccinate their children against HPV, whereas cost and religious and cultural beliefs seemed to have no impact.

Conclusion
Most parents in our study did not vaccinate or weren’t willing to vaccinate their children against HPV even when they were in favor of vaccines in general. Physician recommendation was shown to be one of the most important predictors of vaccination. Effort should be put into educating parents about the importance of the vaccine and its well-established safety and efficacy regardless of gender. Lebanese physicians should also be educated and empowered to recommend HPV vaccine more strongly and consistently.
Systematic Evaluation of Clinical, Nutritional, and Fecal Microbial Factors for Their Association With Colorectal Polyps
Authors: Schult David , Maurer H. Carlo , Frolova Marina , Ringelhan Marc , Mayr Ulrich , Ulrich Jörg , Heilmaier Markus , Rasch Sebastian , Lahmer Tobias , Reitmeier Sandra , Hennig Chiara , Gassner Christina , Thur Niklas , Will Theresa , Janssen Klaus-Peter , Steiger Katja , Jesinghaus Moritz , Neuhaus Klaus , Quante Michael , Haller Dirk , Abdelhafez Mohamed , Schmid Roland M. , Middelhoff Moritz 
Published: December 2023

INTRODUCTION:
The identification of risk factors for precursor lesions of colorectal cancer (CRC) holds great promise in the context of prevention. With this study, we aimed to identify patient characteristics associated with colorectal polyps (CPs) and polyp features of potential malignant progression. Furthermore, a potential association with gut microbiota in this context was investigated.

METHODS:
In this single-center study, a total of 162 patients with CPs and 91 control patients were included. Multiple variables including information on lifestyle, diet, serum parameters, and gut microbiota, analyzed by 16S-rRNA gene amplicon sequencing and functional imputations (Picrust2), were related to different aspects of CPs.

RESULTS:
We observed that elevated serum alkaline phosphatase (AP) levels were significantly associated with the presence of high-grade dysplastic polyps. This association was further seen for patients with CRC. Thereby, AP correlated with other parameters of liver function. We did not observe significant changes in the gut microbiota between patients with CP and their respective controls. However, a trend toward a lower alpha-diversity was seen in patients with CRC. Interestingly, AP was identified as a possible clinical effect modifier of stool sample beta diversity.

DISCUSSION:
We show for the first time an increased AP in premalignant CP. Furthermore, AP showed a significant influence on the microbial composition of the intestine. Relatively elevated liver enzymes, especially AP, may contribute to the detection of precancerous dysplastic or neoplastic changes in colorectal lesions. The association between elevated AP, premalignant CP, and the microbiome merits further study.
Accuracy prediction of wearable flexible smart gloves
Authors: Zhang Yan , Xie Hong , Lake Mark J. 
Published: December 2023

Abstract
This article aimed at providing a new biomechanical three-dimensional dynamic finite element model of the hand–glove combination for exploring the distribution of the overall continuous dynamic contact pressure of the hand with the flexible glove in the state of grabbing an object, and further predicting the accuracy of sensors of wearable smart gloves. The model was validated by garment pressure experiments at eight muscle points. The results showed that the pressure value measured with three flexible gloves was highly consistent with the finite element simulation value. Based on the model, the distribution of dynamic pressure between the soft tissue of the hand and the fabric in the process of flexing the fingers and grabbing external objects were predicted accurately and effectively, which indicated that the model with high accuracy could be applied to evaluate the accuracy of the pressure value collected by sensors of smart gloves. In addition, the model had been confirmed that it has a certain application value. The findings could help to provide a reference for dynamic continuous monitoring equipment or other intelligent wearable devices, and promote the development of the intelligent clothing industry in the future.
From slides to insights: Harnessing deep learning for prognostic survival prediction in human colorectal cancer histology
Authors: Verma Jyoti , Sandhu Archana , Popli Renu , Kumar Rajeev , Khullar Vikas , Kansal Isha , Sharma Ashutosh , Garg Kanwal , Kashyap Neeru , Aurangzeb Khursheed 
Published: December 2023

Abstract
Prognostic survival prediction in colorectal cancer (CRC) plays a crucial role in guiding treatment decisions and improving patient outcomes. In this research, we explore the application of deep learning techniques to predict survival outcomes based on histopathological images of human colorectal cancer. We present a retrospective multicenter study utilizing a dataset of 100,000 nonoverlapping image patches from hematoxylin & eosin-stained histological images of CRC and normal tissue. The dataset includes diverse tissue classes such as adipose, background, debris, lymphocytes, mucus, smooth muscle, normal colon mucosa, cancer-associated stroma, and colorectal adenocarcinoma epithelium. To perform survival prediction, we employ various deep learning architectures, including convolutional neural network, DenseNet201, InceptionResNetV2, VGG16, VGG19, and Xception. These architectures are trained on the dataset using a multicenter retrospective analysis approach. Extensive preprocessing steps are undertaken, including image normalization using Macenko’s method and data augmentation techniques, to optimize model performance. The experimental findings reveal promising results, demonstrating the effectiveness of deep learning models in prognostic survival prediction. Our models achieve high accuracy, precision, recall, and validation metrics, showcasing their ability to capture relevant histological patterns associated with prognosis. Visualization techniques are employed to interpret the models’ decision-making process, highlighting important features and regions contributing to survival predictions. The implications of this research are manifold. The accurate prediction of survival outcomes in CRC can aid in personalized medicine and clinical decision-making, facilitating tailored treatment plans for individual patients. The identification of important histological features and biomarkers provides valuable insights into disease mechanisms and may lead to the discovery of novel prognostic indicators. The transparency and explainability of the models enhance trust and acceptance, fostering their integration into clinical practice. Research demonstrates the potential of deep learning models for prognostic survival prediction in human colorectal cancer histology. The findings contribute to the understanding of disease progression and offer practical applications in personalized medicine. By harnessing the power of deep learning and histopathological analysis, we pave the way for improved patient care, clinical decision support, and advancements in prognostic prediction in CRC.
Rejection and symmetric difference of bipolar picture fuzzy graph
Authors: Almousa Maha Mohammed , Tchier Fairouz 
Published: December 2023

Abstract
Due to the absence of a negative of three membership functions, there are drawbacks to the existing definition of a picture fuzzy graph (PFG). In that definition of bipolar picture fuzzy graph (BPFG), membership function, neutral membership function, nonmembership function, negative of membership function, negative of neutral membership function, and negative of nonmembership function are involved. A BPFG is the extension of PFG. In this manuscript, we present some properties of symmetric difference, and rejection of BPFG.
Solar energy harvesting-based built-in backpack charger
Authors: Selim Kyrillos K. , Khalid Saeid , El-nawam Dina , Fattah Mohamed Abdel , Saleeb Demyana A. 
Published: December 2023

Abstract
Developing renewable energy sources has gained considerable attention recently. Solar energy is the fastest-growing alternative renewable energy source. A solar energy harvesting-based built-in backpack charger is introduced here. The proposed system aims to utilise the surrounding solar energy and overcome the power limitations of batteries installed in mobile phones in cases where power sockets are unavailable. A 6 cm × 6 cm solar module is employed. Additionally, current, voltage, and power were measured under the two scenarios; the first scenario is when the electrical load is 100 Ω, and the second scenario is when the load is a power bank. The maximum harvested power noticed in the first scenario of the resistive load was 140 mW by the proposed system in the southeast direction from 10:30 a.m. to 4:30 p.m. Moreover, the top-generated output voltage and current in this scenario were 3.6 V and 36 mA. On the other hand, 55 mW was the top value for the second scenario of the power bank as a load in the flat direction with the highest generated output voltage and current of 4.1 V and 13 mA, whereas 4.27 V was the highest generated voltage in this scenario in the west direction.
Complete recovery after glucocorticoid replacement therapy in a case of primary adrenal insufficiency caused by adrenal tuberculosis infection
Authors: Zufry Hendra , Zulfa Putri Oktaviani , Rosdiana Rosdiana , Sucipto Krishna Wardhana , Ekadamayanti Agustia Sukri , Firdausa Sarah 
Published: December 2023

Summary
Symptoms of primary adrenal insufficiency (PAI) are commonly nonspecific, causing the disease to be misdiagnosed or often delayed, and patients may present to the hospital with a life-threatening crisis. Previous case reports have documented that patients in this condition often require lifelong glucocorticoid replacement therapy. This study aimed to present a noteworthy outcome of PAI caused by adrenal tuberculosis infection, demonstrating complete recovery after six months of glucocorticoid replacement therapy. A 38-year-old Indonesian man presented to the endocrinology clinic in a tertiary hospital with a chief complaint of epigastric pain. The patient experienced nausea, vomiting, loss of consciousness, weight loss, excessive sweat, decreased appetite, weakness, and dizziness in the past 2 weeks. Laboratory examinations revealed hyponatremia, elevated adrenocorticotropic hormone, and suppressed morning plasma cortisol level. A non-contrast-enhanced abdominal MRI showed unilateral right-side adrenal enlargement and calcification. The patient’s Mantoux test was positive. Corticosteroids and anti-tuberculosis therapy were administered. After 6 months, hydrocortisone was discontinued due to the patient’s good clinical condition and normal morning plasma cortisol levels. After a 1-year follow-up, the patient remained asymptomatic with normal cortisol levels. We hypothesized several reasons for this unique outcome: (i) the patient was relatively young compared to previous cases, suggesting an adequate immune system may play a role; (ii) despite a 1-month delay in diagnosis and treatment, the absence of skin hyperpigmentation suggested an acute presentation, potentially contributing to the favorable outcome; and (iii) the absence of comorbidities potentially positively impacted the patient's outcome.

Learning points

Symptoms of adrenal insufficiency are often nonspecific and may only become apparent once significant damage has occurred to the adrenal gland.

Clinical adjustments and a comprehensive understanding of epidemiological knowledge are necessary for diagnosing patients with endocrine diseases in limited-resource settings.

Complete recovery in primary adrenal insufficiency caused by tuberculosis infection might be due to younger age, acute presentation, and absence of comorbidities
Modeling the deformation of the semiconductor quantum dot with a multilayer shell in a living cell
Authors: Kuzyk O.V. , Dan'kiv O.O. , Peleshchak R.M. , Stolyarchuk I.D. , Kuhivchak V.A. 
Published: December 2023

The model of the semiconductor quantum dot with a multilayer shell and the quantum dot-human serum albumin bionanocomplex, which are contained in a living cell, was constructed. The regularities of changes in deformation of materials of the CdSe-core / ZnS/CdS/ZnS-shell quantum dot with changes in cell elasticity (comprehensive modulus) at different core radii, thicknesses of individual shell layers, and surface concentration of albumin molecules were investigated. It is shown that the presence of human serum albumin on the surface of the quantum dot significantly increases its sensitivity to pressure caused by the surrounding medium (living cell). The obtained results indicate the prospect of using the core-shell quantum dot-human serum albumin bionanocomplexes for the diagnosis of cancer diseases in the early stages. This is due to the fact that such diseases are accompanied by a sharp change in the elasticity of the cell (its elastic constants).
GÊNERO E ALFABETIZAÇÃO NO BRASIL DE 1940 A 2000: A HISTÓRIA QUANTITATIVA DA RELAÇÃO
Authors: Ravanello Ferraro Alceu 
Published: December 2023

El objetivo de este trabajo es enfocar la relación entre género y alfabetización. Cuestiona la sensibilidad y adecuación del indicador ¨tasa de analfabetismo para las personas de 15 años o más¨, utilizado en varios estudios patrocinados por la UNESCO. En el texto, se argumenta que ese indicador es incapaz de captar las transformaciones en curso en la relación entre género y alfabetización, precisamente por no tener en cuenta el efecto generacional, es decir, el efecto de las distintas edades en la tasa de alfabetización o analfabetismo de acuerdo con el género. La argumentación se basa sobre todo en un estudio de caso, cuyo foco está en la trayectoria de la relación entre género y alfabetización en Brasil, durante el periodo comprendido entre 1940 y 2000. El estudio revela que ya desde el Censo 1940 (estudio estadístico demográfico) había más mujeres alfabetizadas que hombres. Esta diferencia se observaba, en principio, en los grupos más jóvenes (5 a 9 años y 10 a 14 años); sin embargo, en el Censo 2000, se extendía al grupo de 40 a 44 años. A partir de estos datos, se sostiene que lo que ocurre –y no solamente en Brasil- es una inversión histórica en la relación entre género y educación como un todo. En este trabajo, se mapean algunas hipótesis de interpretación o explicación del fenómeno en la literatura internacional. Por último, el texto se pregunta qué significados puede tener ese cambio de interpretación en términos de superación de la histórica desigualdad de condiciones entre mujeres y hombres.
A vállalati biztonsági háló meghatározó tényezői
Authors: Kemendi Ágnes 
Published: December 2023

Összefoglalás.

A ma vállalata dinamikusan változó üzleti és kockázati környezetben működik,
behálózzák az információs és kommunikációs technológiák. Mindez a biztonság
területén is felkészültséget igényel. A sikeres vállalati működés fontos pillére
a kívánt biztonsági szint megteremtése és fenntartása. Jelen tanulmány szakértői
kutatás eredményeit tartalmazza, és a megalapozott elmélet módszertana alapján
készült. A kutatás a nyereségorientált vállalatok szemszögéből vizsgálja a
biztonság kérdéskörét, javaslatokat tesz, eszközöket mutat ebben a dinamikus és
innovatív környezetben a biztonsági kérdések kezelésére, és azonosítja a
vállalatot behálózó belső kontrollrendszer, az ún. vállalati biztonsági háló
meghatározó tényezőit. A kutatás lényeges megállapítása, hogy a vállalati
biztonsági háló kulcseleme a vezetői elkötelezettség.

Summary.

A company of these days operates in a dynamically changing business- and risk
environment, surrounded by information and communication technologies; all this
calls for thorough grounding in the field of security. This study contains the
results of expert research and was prepared based on the methodology of grounded
theory. The research examines the matter of security from the perspective of
profit-oriented companies; makes suggestions and shows tools on how to ensure
the smooth handling of security matters in this dynamic and innovative
environment, and furthermore identifies what is the determining factor in the
digital age behind the operation of the internal control system that encompasses
the company, the so-called corporate safety-net. Security represents value for
companies, its economic benefit must be shown to decision-makers. Resiliency is
important from business and security perspective as well.
The safe operation of business processes requires the appropriate management of
related risks, i.e., controlled processes, tools, or appropriate management of
human risks are necessary. A network-like relationship can be identified between
the key factors of corporate security. Safe operation requires safety-conscious,
and rule-following behaviour of the human factors. Staying up-to-date in the
digital era requires both up-to-date digital technology solutions and up-to-date
users and developers of the solutions. This can be ensured through continuous
learning and development. The security aspects of digital transformation
projects should be diligently managed from the very beginning of the development
process of the digital solution, as well as people should accept and support the
changes. The design and operational testing of controls are the keys to ensure
safe operation later on.
The key finding of the research is that the key element of the corporate
safety-net is top management commitment that is the most important factor
determining a company’s safety culture and corporate security.