bluuebunny/crossref_metadata_2025_split huggingface dataset:
Hypometabolic patterns are related to post‐surgical seizure outcomes in focal cortical dysplasia: A semi‐quantitative study
Authors: Yao Yuan , Wang Xiu , Zhao Baotian , Mo Jiajie , Guo Zhihao , Yang Bowen , Li Zilin , Fan Xiuliang , Cai Du , Sang Lin , Zheng Zhong , Shao Xiaoqiu , Ai Lin , Hu Wenhan , Zhang Chao , Zhang Kai 
Published: January 2024

AbstractObjectiveFluorine‐18‐fluorodeoxyglucose–positron emission tomography (FDG‐PET) is routinely used for presurgical evaluation in many epilepsy centers. Hypometabolic characteristics have been extensively examined in prior studies, but the metabolic patterns associated with specific pathological types of drug‐resistant epilepsy remain to be fully defined. This study was developed to explore the relationship between metabolic patterns or characteristics and surgical outcomes in type I and II focal cortical dysplasia (FCD) patients based on results from a large cohort.MethodsData from individuals who underwent epilepsy surgery from 2014 to 2019 with a follow‐up duration of over 3 years and a pathological classification of type I or II FCD in our hospital were retrospectively analyzed. Hypometabolic patterns were quantitatively identified via statistical parametric mapping (SPM) and qualitatively analyzed via visual examination of PET‐MRI co‐registration images. Univariate analyses were used to explore the relationship between metabolic patterns and surgical outcomes.ResultsIn total, this study included data from 210 patients. Following SPM calculations, four hypometabolic patterns were defined including unilobar, multi‐lobar, and remote patterns as well as cases where no pattern was evident. In type II FCD patients, the unilobar pattern was associated with the best surgical outcomes (p = 0.014). In visual analysis, single gyrus (p = 0.032) and Clear‐cut hypometabolism edge (p = 0.040) patterns exhibited better surgery outcomes in the type II FCD group.ConclusionsPET metabolic patterns are well‐correlated with the prognosis of type II FCD patients. However, similar correlations were not observed in type I FCD, potentially owing to the complex distribution of the epileptogenic region.Plain Language SummaryIn this study, we demonstrated that FDG‐PET was a crucial examination for patients with FCD, which was a common cause of epilepsy. We compared the surgical prognosis for patients with different hypometabolism distribution patterns and found that clear and focal abnormal region in PET was correlated with good surgical outcome in type II FCD patients.
Menstrual characteristics of atypical anorexia nervosa
Authors: Aygün Ari Demet , Pehlivantürk Kizilkan Melis , Derman Orhan , Akgül Sinem 
Published: January 2024

AbstractObjectiveWhile menstrual irregularities are acknowledged in restrictive‐type eating disorders (EDs), the menstrual characteristics specific to atypical anorexia nervosa (AAN) remain inadequately defined. This study aims to compare the menstrual features of anorexia nervosa (AN) and AAN.MethodAdolescents diagnosed with AN or AAN who exhibited secondary amenorrhoea at presentation and had their menstrual cycles restored during follow‐up were eligible for this study. Clinical and menstrual data at admission and during follow‐up were obtained from patient files, and compared between the AN and AAN cohorts.ResultsThe study included a total of 77 patients (38 with AN and 39 with AAN). The extent of weight loss and the disease duration until the onset of amenorrhoea were comparable in the two groups. However, the duration of illness and the time since the last menstrual period at admission were shorter in the AAN group. Moreover, amenorrhoea manifested at a higher body mass index, and the return of menses occurred more rapidly with less weight gain in the AAN group after the onset of clinical follow‐up. Additionally, the AAN group exhibited a shorter overall duration of amenorrhoea.ConclusionsThis study highlights the significance of recognising amenorrhoea in restrictive disorders, even when individuals maintain a normal weight. The faster return of menstrual cycles and shorter duration of amenorrhoea observed in adolescents with AAN emphasise the significance of early diagnosis and prompt initiation of treatment. Regardless of the patient's presenting complaint and weight status, obtaining a comprehensive ED history is essential when addressing concerns regarding amenorrhoea or menstrual irregularities.
Recent progress in quantitative analysis of self‐assembled peptides
Authors: Cai Xiaoyao , Xu Wei , Ren Chunhua , Zhang Liping , Zhang Congrou , Liu Jianfeng , Yang Cuihong 
Published: January 2024

AbstractSelf‐assembled peptides have been among the important biomaterials due to its excellent biocompatibility and diverse functions. Over the past decades, substantial progress and breakthroughs have been made in designing self‐assembled peptides with multifaceted biomedical applications. The techniques for quantitative analysis, including imaging‐based quantitative techniques, chromatographic technique and computational approach (molecular dynamics simulation), are becoming powerful tools for exploring the structure, properties, biomedical applications, and even supramolecular assembly processes of self‐assembled peptides. However, a comprehensive review concerning these quantitative techniques remains scarce. In this review, recent progress in techniques for quantitative investigation of biostability, cellular uptake, biodistribution, self‐assembly behaviors of self‐assembled peptide etc., are summarized. Specific applications and roles of these techniques are highlighted in detail. Finally, challenges and outlook in this field are concluded. It is believed that this review will provide technical guidance for researchers in the field of peptide‐based materials and pharmaceuticals, and facilitate related research for newcomers in this field.
Financial (dis)incentives to surgical management of head and neck cancer care
Authors: Aschen Seth Z. , O'Connell Gillian M. , Kutler David I. , Spector Jason A. 
Published: January 2024

AbstractBackgroundPatients with head and neck cancer (HNC) often require complex surgical reconstruction. This retrospective, cross‐sectional study compares financial factors influencing HNC and breast cancer (BC) care to examine care disparities.MethodsPricing data from 2012 to 2021 was abstracted from the CMS Physician Fee Schedule Look‐Up Tool. Nonprofit and research support was quantified by searching the NIH, IRS, and GuideStar databases. New York State Department of Health data from 2015 to 2019 was analyzed to compare costs, charges, and payer mix.ResultsHNC reconstructive procedures reimburse lower than comparable breast procedures (p < 0.05). Nonprofit and research support for HNC is disproportionately low relative to disease burden. Patients hospitalized for HNC surgical procedures generated higher costs and lower charges than patients with BC (p < 0.05).ConclusionComparatively low procedure reimbursement, low nonprofit support, and high cost of care for patients with HNC relative to patients with BC may contribute to care disparities for patients with HNC.
Efficacy of photobiomodulation therapy in the management of oral mucositis in patients with head and neck cancer: A systematic review and meta‐analysis of randomized controlled trials
Authors: Shen Bin , Zhou Yaoying , Wu Dongping , Liu Jianjiang 
Published: January 2024

AbstractNumerous studies have examined the effectiveness of photobiomodulation therapy (PBMT) in reducing chemoradiotherapy (CRT)‐induced oral mucositis (OM) in patients with head and neck cancer (HNC). Despite this, there is an urgent need to update the meta‐analyses on this topic. This meta‐analysis aims to explore the impact of PBMT on CRT‐induced OM in these patients. We conducted a systematic search in PubMed, Embase, Cochrane, LILACS, and Web of Science from January 2000 to October 2023. This search focused on randomized controlled trials (RCTs) that assessed the effects of PBMT on CRT‐induced OM. The study included a total of 14 RCTs encompassing 869 patients with HNC. The incidence of OM in the PBMT group was significantly lower from the second week onwards compared to the control group (RR = 0.49, CI = 0.25–0.97, I2 = 71%, p = 0.04), and this was present until the seventh week (RR = 0.77, CI = 0.61–0.99, I2 = 89%, p = 0.04). Furthermore, the occurrence of severe mucositis in the PBMT group decreased from the third week (RR = 0.51, CI = 0.29–0.90, I2 = 12%, p = 0.02) until the conclusion of the intervention (RR = 0.45, CI = 0.24–0.85, I2 = 80%, p = 0.01). Additionally, PBMT showed beneficial effects in alleviating OM‐related pain (WMD = −1.09, 95% CI = −1.38 to −0.880, I2 = 13%, p < 0.00001). The use of He‐Ne or InGaAlP lasers with a power range of 10–25 mW demonstrated the most favorable outcomes in preventing and treating OM. PBMT has shown considerable efficacy in reducing the incidence, severity, and pain associated with OM in patients with HNC. Future studies are encouraged to further investigate the most effective parameters for PBMT in the management of OM.
Knots of the umbilical cord: Incidence, diagnosis, and management
Authors: Al Qasem Malek , Meyyazhagan Arun , Tsibizova Valentina , Clerici Graziano , Arduini Maurizio , Khader Mohammed , M. Alkarabsheh Ahlam , Di Renzo Gian Carlo 
Published: January 2024

AbstractKnot(s) of the umbilical cord have received emphasis because the clinical assessments and sonographic literature show a crucial role in fetal outcomes. The true umbilical cord knot could be a knot in a singleton pregnancy or an entanglement of two umbilical cords in monoamniotic twins. Clinical manifestations are almost silent, which can raise clinical challenges. They worsen outcomes, and the pathology can be easily missed during prenatal visits because ultrasonographers do not pay attention to the cord during an obstetric ultrasound scan. However, most medical centers now have ultrasound machines that improve fetal assessment. The umbilical cord should be routinely evaluated during a fetal assessment, and suspicion of an umbilical cord knot can be more frequently diagnosed and is detected only incidentally. Clinical outcome is usually good but depends on the knot's characteristics and if it is tight or loose. In this review, we discuss pathophysiology, the theories on formation, the main risk factors, ultrasound signs and findings, different opinions in the management, and features of pregnancy outcomes feature.
Recent advances in photobiomodulation therapy for brain diseases
Authors: Dong Sihan , Ren Hang , Zhang Rui , Wei Xunbin 
Published: January 2024

AbstractLight therapy techniques, such as photobiomodulation therapy (PBMT), photodynamic therapy (PDT), and laser photoablation, have gained widespread attention and become indispensable physiotherapy methods in clinical practice. PBMT involves the application of low‐level laser/LED to modulate the function of nerve cells, relieve neuroinflammation, promote neurogenesis and vascular growth. Recent studies have shown that PBMT holds promise as a complementary or alternative treatment of Alzheimer's disease (AD), traumatic brain injury (TBI), major depressive disorder (MDD), etc. However, the therapeutic effect of PBMT is influenced by various factors, such as the patients' condition, brain structure and function, illumination parameters, etc. Therefore, the optimized parameters, personalized therapeutic schedules, and precise evaluation of the therapeutic effect are crucial to the treatment success. In this review, we identified the recent experimental and clinical successes, existing obstacles, and future opportunities for PBMT in the treatment of the brain diseases. As a non‐invasive, side‐effect‐free, and highly accessible technique, PBMT brings a glimmer of light for the treatment of neuropsychiatric disorders and the neuro‐rejuvenation of human brains.
Experiential avoidance as a mediator of risk factors for higher order internalizing psychopathology in the perinatal period
Authors: Miller Michelle L. , Jiang Lily J. , O'Hara Michael W. 
Published: January 2024

AbstractObjectivesPerinatal psychopathology can be damaging. This study examined the strength of the associations between risk factors and all perinatal mood and anxiety disorder symptoms while assessing the mediating effect of experiential avoidance.MethodParticipants (N = 246) completed assessments during pregnancy (28–32 weeks) and the postpartum (6–8 weeks). Structural equation modeling (SEM) was used to examine associations between risk factors and latent factors: distress (composed of depression, generalized anxiety, irritability, and panic symptoms); fear (social anxiety, agoraphobia, specific phobia, and obsessive‐compulsive); and bipolar (mania and obsessive‐compulsive).ResultsDuring pregnancy, past psychiatric history, anxiety sensitivity, maladaptive coping, and age were significant risk factors. In the postpartum, negative maternal attitudes and past psychiatric history were only risk factors for symptoms that composed distress. Experiential avoidance mediated the relation between maladaptive coping and symptoms that composed fear.ConclusionIt is important to assess for psychological risk factors starting in pregnancy. This study identified critical risk factors that are associated with the underlying commonality among perinatal mood and anxiety symptoms. Some of the risk factors as well as the mediator are malleable (negative maternal attitudes, experiential avoidance), creating new possibilities for prevention and treatment of perinatal mood and anxiety disorder symptoms.
The association of childhood trauma with suicidality in adult psychiatric patients: The mediating role of NSSI and the moderating role of self‐esteem
Authors: Zhou Jing , Hu Tao , Xue Shuang , Dong Zaiquan , Tang Wanjie 
Published: January 2024

AbstractBackgroundThe contribution of specific childhood trauma subtypes to suicidal thoughts and the associated mechanisms remains unclear, particularly in psychiatric patients.MethodsFace‐to‐face interviews were conducted with 449 psychiatric patients aged 18–73. Childhood trauma, self‐esteem, nonsuicidal self‐injury (NSSI), and suicidality were assessed retrospectively. Regression and moderated mediation model were employed to examine these relationships.ResultsEmotional and sexual abuse were independently associated with suicidality. Female patients reported higher levels of emotional and sexual abuse, lower self‐esteem, and a heightened risk of suicide. Self‐esteem moderated the links between childhood trauma and NSSI, as well as between NSSI and suicidality. NSSI served as a mediator between childhood trauma and suicidality.ConclusionsSuicide prevention in mentally ill patients should involve targeted programs addressing specific childhood trauma. Additionally, psychological interventions to enhance self‐esteem and assist individuals engaging in NSSI behavior are crucial.
The State of National Institute of Health Awards for funding genetic counseling research, resources, and training over the past decade
Authors: Zierhut Heather , Betterman Samantha , Kocher Megan , Tsegai Hiermiela , Mills Rachel 
Published: January 2024

AbstractResearch related to the practice of genetic counseling has historically been accomplished through student projects, small private grants, or as a part of a larger research study. Yet, recent initiatives supported by the National Society of Genetic Counselors and the National Human Genome Research Institute have recognized and promoted the need for additional genetic counseling research funding and training. In this study, we aimed to characterize awards from the United States' National Institutes of Health (NIH) over the past 10 years that support research related to genetic counseling. A search of the NIH RePORTER database conducted on April 25, 2022, using terms broadly related to genetic counseling, identified 3993 awards from fiscal years 2011 to 2022. After deduplication, 1231 grants were reviewed for screening. The final dataset included 43 awards of various types with the majority being research or R series grants [R01 (n = 17), R21 (n = 7)]. The remaining awards were Cooperative Agreements (U01, n = 6), intramural (Z‐grants, n = 5), Center Core (P30, n = 2), Specialized Center (P50, n = 1), Career Development Award (K01, n = 1), Other Transactions (OT2, n = 1), Resource Program (G13, n = 1), and Research Training and Fellowship (T32, n = 1). Most grants were awarded between 2019 and 2022 (n = 24, 55.8%). The majority of awards were categorized as studies that included a comparison of different genetic counseling models (n = 23), outcomes of implementing genetic counseling (n = 11), core resources for genetic counselors (n = 5), and genetic counseling training programs (n = 4). Thirteen of the awards (30.2%) had a specific aim/goal/focus on underserved or underrepresented populations. The topics were predominantly related to cancer (n = 26). Nine awards were led or co‐led by a genetic counselor (20.9%). Despite significant growth in genetic counseling research support from US‐based funders over the past 3 years, major gaps related to funding exist, including that most award recipients are not genetic counselors.
The effect of pre‐interview knowledge and instructions on interviewer memory
Authors: Rivard Jillian R. , LaBat Devon E. , Carlson Victoria , Compo Nadja Schreiber 
Published: January 2024

AbstractSkilled investigative interviewing is critical to ensuring that credible witness accounts are gathered in criminal investigations. The current study aimed to determine whether instructions to avoid suggestive questions and pre‐interview knowledge influence both the quality of an interviewer's questioning strategy and the interviewer's memory for the witness' account after a 1‐week delay in a laboratory study using lay student interviewers and witnesses. Results indicated that access to case details prior to the interview did not significantly influence the type or quality of questions asked within the interview itself but significantly influenced interviewers' memories for their interview 1 week later. Those who were blind to case information at the time of the interview had more accurate memories of their witness interviews than those who were correctly or incorrectly pre‐informed. Instructions to avoid suggestive questions served to reduce suggestive questions, regardless of pre‐interview knowledge. Taken together, these findings suggest that pre‐interview preparation may influence investigative outcomes beyond the interview context and traditional measures of witness accuracy.
Association between rheumatoid arthritis and atrial fibrillation: A systematic review and meta‐analysis
Authors: Jaiswal Vikash , Roy Poulami , Ang Song Peng , Shama Nishat , Deb Novonil , Taha Amira Mohamed , Rajak Kripa , Sharma Akanksha , Halder Anupam , Wajid Zarghoona , Agrawal Vibhor , Khela Harpriya , Biswas Monodeep 
Published: January 2024

AbstractRheumatoid arthritis (RA) is an autoimmune disorder with a varying range of organs involved leading to adverse outcomes. However, very little is known, with conflicting results about the association between RA and atrial fibrillation (AF). We aim to evaluate the association between RA and AF, and other clinical outcomes. We performed a systematic literature search using PubMed, Embase, and Scopus for relevant articles from inception until September 10, 2023. Primary clinical outcomes were AF. Secondary outcomes were acute coronary syndrome (ACS), stroke, and all‐cause mortality (ACM). A total of 4 679 930 patients were included in the analysis, with 81 677 patients in the RA group and 4 493 993 patients in the nonrheumatoid arthritis (NRA) group. The mean age of the patients was 57.2 years. Pooled analysis of primary outcomes shows that RA groups of patients had a significantly higher risk of AF (odds ratios [OR], 1.53; 95% confidence interval [CI]: [1.16–2.03], p < .001) compared with NRA groups. Secondary Outcomes show that the RA group of patients had significantly higher odds of ACS (OR, 1.39; 95% CI: [1.26–1.52], p < .001), and ACM (OR, 1.19; 95% CI: [1.03–1.37], p = .02) compared with the NRA groups. However, the likelihood of stroke (OR, 1.02; 95% CI: [0.94–1.11], p = .61) was comparable between both groups of patients. Our study shows that RA groups of patients are at increased risk of having AF, ACS, and ACM.
So you want to publish in a premier journal? An illustrative guide on how to develop and write a quantitative research paper for premier journals
Authors: Lim Weng Marc , Koay Kian Yeik 
Published: January 2024

AbstractPublishing in premier journals is a multifaceted challenge that requires not only conducting impactful research but also mastering the art of scholarly writing. This article offers a comprehensive guide, specifically tailored for quantitative research, a dominant methodology in premier journals. The guide systematically navigates through each section of a quantitative research paper—title, abstract, keywords, introduction, literature review, methodology, results, discussion, conclusion, and references—providing clear, actionable advice. Drawing from a research publication in a Q1‐ranked journal as an illustration, this guide elucidates the nuances of constructing an engaging and rigorous quantitative research paper. The guide also delves into the expectations of editors and reviewers, offering innovative strategies and insights to enhance the clarity, coherence, and persuasiveness of submissions. Designed to resonate deeply with quantitative scholars, this guide empowers researchers to craft research papers that not only align but surpass the expectations of premier journals.
Frequency of use and adequacy of Cochrane risk of bias tool 2 in non‐Cochrane systematic reviews published in 2020: Meta‐research study
Authors: Babić Andrija , Barcot Ognjen , Visković Tomislav , Šarić Frano , Kirkovski Aleksandar , Barun Ivana , Križanac Zvonimir , Ananda Roshan Arjun , Fuentes Barreiro Yuli Viviana , Malih Narges , Dimcea Daiana Anne‐Marie , Ordulj Josipa , Weerasekara Ishanka , Spezia Matteo , Žuljević Marija Franka , Šuto Jelena , Tancredi Luca , Pijuk Anđela , Sammali Susanna , Iascone Veronica , von Groote Thilo , Poklepović Peričić Tina , Puljak Livia 
Published: January 2024

AbstractRisk of bias (RoB) assessment is essential to the systematic review methodology. The new version of the Cochrane RoB tool for randomized trials (RoB 2) was published in 2019 to address limitations identified since the first version of the tool was published in 2008 and to increase the reliability of assessments. This study analyzed the frequency of usage of the RoB 2 and the adequacy of reporting the RoB 2 assessments in non‐Cochrane reviews published in 2020. This meta‐research study included non‐Cochrane systematic reviews of interventions published in 2020. For the reviews that used the RoB 2 tool, we analyzed the reporting of the RoB 2 assessment. Among 3880 included reviews, the Cochrane RoB 1 tool was the most frequently used (N = 2228; 57.4%), followed by the Cochrane RoB 2 tool (N = 267; 6.9%). From 267 reviews that reported using the RoB 2 tool, 213 (79.8%) actually used it. In 26 (12.2%) reviews, erroneous statements were used to indicate the RoB 2 assessment. Only 20 (9.4%) reviews presented a complete RoB 2 assessment with a detailed table of answers to all signaling questions. The judgment of risk of bias by the RoB 2 tool was not justified by a comment in 158 (74.2%) reviews. Only in 33 (14.5%) of reviews the judgment in all domains was justified in the accompanying comment. In most reviews (81.7%), the RoB was inadequately assessed at the study level. In conclusion, the majority of non‐Cochrane reviews published in 2020 still used the Cochrane RoB 1 tool. Many reviews used the RoB 2 tool inadequately. Further studies about the uptake and the use of the RoB 2 tool are needed.