bluuebunny/crossref_metadata_2025_split huggingface dataset:
A comprehensive review on the chemical constituents, sesquiterpenoid biosynthesis and biological activities of Sarcandra glabra
Authors: Chu Jin-Ning , Krishnan Premanand , Lim Kuan-Hon 
Published: November 2023

AbstractSarcandra glabra (Thunb.) Nakai is a perennial evergreen herb categorised within the Sarcandra Gardner genus under the Chloranthaceae family. Indigenous to tropical and subtropical regions of East Asia and India, this species is extensively distributed across China, particularly in the southern regions (Sichuan, Yunnan, and Jiangxi). In addition to its high ornamental value, S. glabra has a rich history of use in traditional Chinese medicine, evident through its empirical prescriptions for various ailments like pneumonia, dysentery, fractures, bruises, numbness, amenorrhea, rheumatism, and other diseases. Besides, modern pharmacological studies have revealed various biological activities, such as antitumour, anti-bacterial, anti-viral anti-inflammatory and immunomodulatory effects. The diverse chemical constituents of S. glabra have fascinated natural product researchers since the 1900s. To date, over 400 compounds including terpenoids, coumarins, lignans, flavonoids, sterols, anthraquinones, organic acids, and organic esters have been isolated and characterised, some featuring unprecedented structures. This review comprehensively examines the current understanding of S. glabra’s phytochemistry and pharmacology, with emphasis on the chemistry and biosynthesis of its unique chemotaxonomic marker, the lindenane-type sesquiterpenoids.
Graphical Abstract
China Anti-Cancer Association (CACA) guidelines for holistic integrative management of lymphoma (version 2022)
Authors: Zhang Qingyuan , Feng Jifeng , Wang Huaqing , Huang Huiqiang , Zhang Huilai , Li Xiaoqiu , Gao Yuhuan , Song Yongping , Li Zhiming , Bai Ou , Cao Junning , Zhou Hui , Gu Kangsheng , Zhao Shu , Zhao Wenhui , Qin Yan , Li Yajun , Ma Guangyu , Wen Shujuan , Wang Yu , Zhao Peiqi , Guo Wei , Lv Fangfang , Tian Yuyang , Chen Xinrui , Xie Zucheng , Shi Yuankai ,   Lymphoma Committee of China Anti-Cancer Association
Published: November 2023

Abstract
Purpose
Lymphoma has become a major threat to human health. Fortunately, the diagnosis and treatment of lymphoma have developed rapidly, and research progress has emerged in an endless stream, with new drugs emerging one after another. These results are constantly rewriting guidelines changing clinical practice, need to be popularized and applied more widely.

Methods
This guideline has integrated consensuses reached by the Lymphoma Committee of China Anti-Cancer Association (CACA), based on China's practice, tracking previous results of the most advanced clinical researches, absorbing the latest clinical evidence, and referring to domestic and international lymphoma guidelines.

Results
This holistic integrative guideline of lymphoma introduces the latest progress in the diagnosis and treatment of different subtypes of lymphoma, guide the clinical application of new drugs, standardized and precise management for lymphoma patients.

Conclusions
CACA guidelines for holistic integrative management of lymphoma (version 2022) enhance standardization and precision of the management for lymphoma patients in China.
A Perspective on the 2023 Cholera Outbreaks in Zimbabwe: Implications, Response Strategies, and Policy Recommendations
Authors: Olatunji Gbolahan , Kokori Emmanuel , Moradeyo Abdulrahmon , Olatunji Doyin , Ajibola Folake , Otolorin Oluwaseun , Aderinto Nicholas 
Published: November 2023

AbstractCholera continues to severely threaten public health, particularly in regions with inadequate access to clean water and sanitation. Zimbabwe, a southern African nation, has witnessed recurrent cholera outbreaks, highlighting the enduring vulnerabilities faced by communities grappling with these underlying challenges. The 2023 cholera outbreak in Chegutu resulted in a devastating impact, with approximately 100 reported deaths and nearly 5000 confirmed and suspected cases. Beyond its immediate health consequences, the outbreak has strained the already fragile healthcare system, exacerbated issues of malnutrition, and disrupted education, particularly affecting vulnerable populations. The Zimbabwean government, non-governmental organisations (NGOs), and international agencies have initiated comprehensive efforts to combat the outbreak, encompassing medical treatment, surveillance, public health measures, infrastructure improvement, and community empowerment. Policy recommendations and future directions are discussed, emphasising risk communication, stakeholder engagement, standardisation, evaluation, resource allocation, and capacity-building to bolster prevention and control measures.
Recent Tangible Natural Variability of Monsoonal Orographic Rainfall in the Eastern Himalayas
Authors: Kad Pratik , Ha Kyung‐Ja 
Published: November 2023

AbstractHimalayas hydroclimate is a lifeline for South Asia's most densely populated region. Every year, flooding in the Himalayan rivers is usual during summer monsoon, which impacts millions of inhabitants of the Himalayas and downstream regions. Recent studies demonstrate the role of melting glaciers and snow in the context of global warming, along with monsoonal rain causing recurrent floods. Here, we highlight the natural variability in the eastern Himalayan hydroclimate over the last 43 years (1979–2021). We found extreme monsoonal rainy years with six dry years and seven wet years after removing the climate change signal. Monsoon rainfall is a significant contributor, and melting snow is not a potential contributor to these anomalous extreme years. The variability of Himalayan monsoonal rainfall is strongly regulated by local monsoonal Hadley circulation associated with tropical sea surface temperature. Our findings demonstrate mechanisms associated with Himalayan wet and dry monsoon. Atmospheric dynamics are attributed as the primary modulating factor, influencing local thermodynamics through moist processes. The insights provided in this study underscore the impact of natural variability‐driven challenging events that could be predictable. Thus, this mechanism could improve the predictability of the Himalayas floods.
A Typical Weakly Forced Mountain‐To‐Plain Extreme Precipitation Event Exacerbated by Urbanization in Beijing
Authors: He Yuting , Wang Jun , Feng Jinming 
Published: November 2023

AbstractThe rainstorms that initiate over mountains, propagate to, and suddenly intensify in nearby plains pose great challenges for weather forecasters and the public. Being in a mountain‐plain transition zone, the city of Beijing is prone to rainfall extremes induced by weakly forced mountain‐to‐plain storms. Despite efforts to understand their possible mechanisms, it remains unclear whether and how these mountain‐to‐plain precipitation extremes are affected by urbanization in Beijing. Here we use a high‐resolution weather prediction model to hindcast a weakly forced mountain‐to‐plain extreme rainfall event impacting Beijing on 23 June 2011. We incorporate spatially varying urban canopy parameters into the model to assess their effect on rainfall simulation and find no significant improvement in model performance. By comparing simulations under current and pre‐urbanization scenarios, we find that urbanization intensifies the regional average rainfall within Beijing's Sixth Ring Road by ∼23%, with an increase in peak hourly rainfall rate reaching 27 mm hr−1. The higher surface roughness and enhanced vertical motions in urban areas facilitate the transport of warm and humid air from lower to mid‐upper layers, fueling the development and maintenance of convective storms. The dragging effect of urban canopy leads to more moisture accumulation and slower‐moving convections, resulting in more rainfall falling in urban areas. Our study underscores the key role of local urbanization in shaping the mountain‐to‐plain rainstorms in Beijing, which may help improve the forecast capacity for these weather extremes and related urban resilience planning.
Nanoengineered, Pd-doped Co@C nanoparticles as an effective electrocatalyst for OER in alkaline seawater electrolysis
Authors: Ghouri Zafar Khan , Hughes David James , Ahmed Khalid , Elsaid Khaled , Nasef Mohamed Mahmoud , Badreldin Ahmed , Abdel-Wahab Ahmed 
Published: November 2023

AbstractWater electrolysis is considered one of the major sources of green hydrogen as the fuel of the future. However, due to limited freshwater resources, more interest has been geared toward seawater electrolysis for hydrogen production. The development of effective and selective electrocatalysts from earth-abundant elements for oxygen evolution reaction (OER) as the bottleneck for seawater electrolysis is highly desirable. This work introduces novel Pd-doped Co nanoparticles encapsulated in graphite carbon shell electrode (Pd-doped CoNPs@C shell) as a highly active OER electrocatalyst towards alkaline seawater oxidation, which outperforms the state-of-the-art catalyst, RuO2. Significantly, Pd-doped CoNPs@C shell electrode exhibiting low OER overpotential of ≈213, ≈372, and ≈ 429 mV at 10, 50, and 100 mA/cm2, respectively together with a small Tafel slope of ≈ 120 mV/dec than pure Co@C and Pd@C electrode in alkaline seawater media. The high catalytic activity at the aforementioned current density reveals decent selectivity, thus obviating the evolution of chloride reaction (CER), i.e., ∼490 mV, as competitive to the OER. Results indicated that Pd-doped Co nanoparticles encapsulated in graphite carbon shell (Pd-doped CoNPs@C electrode) could be a very promising candidate for seawater electrolysis.
Combination of tumor asphericity and an extracellular matrix-related prognostic gene signature in non-small cell lung cancer patients
Authors: Zschaeck Sebastian , Klinger Bertram , van den Hoff Jörg , Cegla Paulina , Apostolova Ivayla , Kreissl Michael C. , Cholewiński Witold , Kukuk Emily , Strobel Helen , Amthauer Holger , Blüthgen Nils , Zips Daniel , Hofheinz Frank 
Published: November 2023

AbstractOne important aim of precision oncology is a personalized treatment of patients. This can be achieved by various biomarkers, especially imaging parameters and gene expression signatures are commonly used. So far, combination approaches are sparse. The aim of the study was to independently validate the prognostic value of the novel positron emission tomography (PET) parameter tumor asphericity (ASP) in non small cell lung cancer (NSCLC) patients and to investigate associations between published gene expression profiles and ASP. This was a retrospective evaluation of PET imaging and gene expression data from three public databases and two institutional datasets. The whole cohort comprised 253 NSCLC patients, all treated with curative intent surgery. Clinical parameters, standard PET parameters and ASP were evaluated in all patients. Additional gene expression data were available for 120 patients. Univariate Cox regression and Kaplan–Meier analysis was performed for the primary endpoint progression-free survival (PFS) and additional endpoints. Furthermore, multivariate cox regression testing was performed including clinically significant parameters, ASP, and the extracellular matrix-related prognostic gene signature (EPPI). In the whole cohort, a significant association with PFS was observed for ASP (p < 0.001) and EPPI (p = 0.012). Upon multivariate testing, EPPI remained significantly associated with PFS (p = 0.018) in the subgroup of patients with additional gene expression data, while ASP was significantly associated with PFS in the whole cohort (p = 0.012). In stage II patients, ASP was significantly associated with PFS (p = 0.009), and a previously published cutoff value for ASP (19.5%) was successfully validated (p = 0.008). In patients with additional gene expression data, EPPI showed a significant association with PFS, too (p = 0.033). The exploratory combination of ASP and EPPI showed that the combinatory approach has potential to further improve patient stratification compared to the use of only one parameter. We report the first successful validation of EPPI and ASP in stage II NSCLC patients. The combination of both parameters seems to be a very promising approach for improvement of risk stratification in a group of patients with urgent need for a more personalized treatment approach.
Performance of hybrid Innegra-carbon fiber composites
Authors: Vaidya Uday , Thattaiparthasarthy Balaji , Janney Mark , Mauhar Mark , Graham Keith , Cates Elizabeth 
Published: November 2023

AbstractIn this work material synergy with high stiffness carbon fiber with ductile high strength polypropylene fiber (Innegra S), (referred to as Innegra, herein) have been evaluated in a range of laminate designs. Both woven and discontinuous carbon fiber have been considered. The discontinuous fibers are based on three-dimensional deposition (3DEP) (referred to as 3DEP, herein) carbon fiber preform process. Eleven (11) variants of Innegra-carbon fiber hybrid laminates were investigated for tensile, flexure, compression, in-plane shear and low velocity impact response. The effect of position of Innegra within the laminate was studied and found to influence strength and stiffness properties. In terms of overall trends, Innegra provides upward of 18% improvement in strain (ductility) to the composite and eliminates brittle fracture of carbon fiber. The moduli trends follow the proportionality of Innegra fiber to carbon fiber plies. However, the strength is controlled by the interface between Innegra and carbon fiber. The primary failure mode in tension and compression is via onset of debonding between Innegra and carbon fiber. The 3DEP carbon fiber constituents provided highest values of in-plane shear indicating that three-dimensional (3D) network of carbon fiber provides higher shear resistance. The Innegra intensive variants exhibited superior energy absorption under low velocity impact, at energy levels 15–60 J. This work provides insight for designers to incorporate Innegra and carbon fiber hybrids in composite structures.
Spatial correlation network structure of energy-environment efficiency and its driving factors: a case study of the Yangtze River Delta Urban Agglomeration
Authors: Liu Shucheng , Yuan Jie 
Published: November 2023

AbstractImproving energy-environment efficiency is not only a requirement for constructing China’s ecological civilization but also inevitable for achieving sustainable economic and social development. Studies on energy-environment efficiency based on relational data and network perspectives are limited, which hinders the development of collaborative regional emission reduction activities. This study uses the SBM-Undesirable model to measure the energy-environment efficiency of the Yangtze River Delta Urban Agglomeration from 2010 to 2020, adopts a modified gravity model and social network analysis to reveal the structural characteristics of its spatial correlation network, and explores its driving factors through the QAP method. The study found (1) an overall upward trend in energy-environment efficiency but with problems of uneven development. (2) The spatial correlation of energy-environment efficiency shows a complex network structure, with increasing network correlation and strong network stability; the network can be divided into four plates: net benefit, net overflow, two-way spillover, and agent. (3) Differences in industrial structure, environmental regulation, economic development, and technological innovation significantly impact the formation of spatial correlation network of energy-environment efficiency. This study provides a reference for the construction of a cross-regional synergistic mechanism to improve energy-environment efficiency.
Synthesis and electrochemical properties of nanocubes Mn2SnS3 for high-performance supercapacitors
Authors: Sanayee Mona , Arvand Majid 
Published: November 2023

AbstractExploring environment-friendly active material-electrolyte combinations has become increasingly necessary with the rising use of supercapacitors. In this study, the potential of ternary Mn2SnS3 on Ni foam as an electrode material was considered. The study investigated the impact of precursors on the morphology of the prepared electrodes utilizing techniques such as X-ray diffraction, energy dispersive X-ray analysis, field-emission scanning electron microscopy, and transmission electron microscopy. Nanocubes Mn2SnS3 (NC-MTS) and nanoworms Mn2SnS3 (NW-MTS) were synthesized via a facile solvothermal route. The results suggest that NC-MTS exhibits better capacitive performance compared with NW-MTS, which means that morphology has a significant effect on the electrochemical reaction. NC-MTS presents excellent supercapacitor performances with a high specific capacity of about 2115 F g−1 at current density 2 A g−1, excellent rate capability of 78% at 17 A g−1 and excellent cycling stability 92% capacitance retention after 3000 GCD cycles. Whereas, NW-MTS illustrated a specific capacity of about 853 F g−1 at current density 2 A g−1, rate capability of 50% at 17 A g−1 and cycling stability of 81% capacitance retention after 3000 GCD cycles. Additionally, an asymmetric supercapacitor NC-MTS/NF//AC based on the NC-MTS/NF as a positive electrode and activated carbon (AC) as a negative electrode was successfully constructed with the excellent electrochemical performance, which demonstrated a high energy density of 60.56 Wh kg−1 and a high power density of 699.89 W kg−1.
In vivo marker of brainstem myelin is associated to quantitative sleep parameters in healthy young men
Authors: Talwar Puneet , Deantoni Michele , Van Egroo Maxime , Muto Vincenzo , Chylinski Daphne , Koshmanova Ekaterina , Jaspar Mathieu , Meyer Christelle , Degueldre Christian , Berthomier Christian , Luxen André , Salmon Eric , Collette Fabienne , Dijk D.-J. , Schmidt Christina , Phillips Christophe , Maquet Pierre , Sherif Siya , Vandewalle Gilles 
Published: November 2023

AbstractThe regional integrity of brain subcortical structures has been implicated in sleep–wake regulation, however, their associations with sleep parameters remain largely unexplored. Here, we assessed association between quantitative Magnetic Resonance Imaging (qMRI)-derived marker of the myelin content of the brainstem and the variability in the sleep electrophysiology in a large sample of 18-to-31 years healthy young men (N = 321; ~ 22 years). Separate Generalized Additive Model for Location, Scale and Shape (GAMLSS) revealed that sleep onset latency and slow wave energy were significantly associated with MTsat estimates in the brainstem (pcorrected ≤ 0.03), with overall higher MTsat value associated with values reflecting better sleep quality. The association changed with age, however (MTsat-by-age interaction—pcorrected ≤ 0.03), with higher MTsat value linked to better values in the two sleep metrics in the younger individuals of our sample aged ~ 18 to 20 years. Similar associations were detected across different parts of the brainstem (pcorrected ≤ 0.03), suggesting that the overall maturation and integrity of the brainstem was associated with both sleep metrics. Our results suggest that myelination of the brainstem nuclei essential to regulation of sleep is associated with inter-individual differences in sleep characteristics during early adulthood. They may have implications for sleep disorders or neurological diseases related to myelin.
Identification of bladder cancer subtypes and predictive model for prognosis, immune features, and immunotherapy based on neutrophil extracellular trap-related genes
Authors: Guo Changhong , Li Peiying , Guo Xingkui , Wang Xinfen , Liu Bo , Cui Liang 
Published: November 2023

AbstractBladder cancer is the most common malignant tumor of urinary system, and its morbidity and mortality are increasing rapidly. Although great advances have been made in medical technology in recent years, there is still a lack of effective prognostic and therapeutic methods for bladder cancer. NETs are reticulated DNA structures decorated with various protein substances released extracellularly by neutrophils stimulated by strong signals. Recently, it has been found that NETs are closely related to the growth, metastasis and drug resistance of many types of cancers. However, up to now, the research on the relationship between NETs and bladder cancer is still not enough. In this study, we aimed to conduct a comprehensive analysis of NRGs in bladder cancer tissues to evaluate the relationship between NRGs and prognosis prediction and sensitivity to therapy in patients with bladder cancer. We scored NRGs in each tissue by using ssGSEA, and selected gene sets that were significantly associated with NRGs scores by using the WCGNA algorithm. Based on the expression profiles of NRGs-related genes, NMF clustering analysis was performed to identify different BLCA molecular subtypes. For the differentially expressed genes between subtypes, we used univariate COX regression, LASSO regression and multivariate COX regression to further construct a hierarchical model of BLCA patients containing 10 genes. This model and the nomogram based on this model can accurately predict the prognosis of BLCA patients in multiple datasets. Besides, BLCA patients classified based on this model differ greatly in their sensitivity to immunotherapy and targeted therapies, which providing a reference for individualized treatment of patients with bladder cancer.
Low sodium availability in hydroponically manipulated host plants promotes cannibalism in a lepidopteran herbivore
Authors: Santiago-Rosario Luis Y. , Salgado Ana L. , Paredes-Burneo Diego , Harms Kyle E. 
Published: November 2023

AbstractAs an abundant element in the Earth’s crust, sodium plays an unusual role in food webs. Its availability in terrestrial environments is highly variable, but it is nonessential for most plants, yet essential for animals and most decomposers. Accordingly, sodium requirements are important drivers of various animal behavioural patterns and performance levels. To specifically test whether sodium limitation increases cannibalism in a gregarious lepidopteran herbivore, we hydroponically manipulated Helianthus annuus host plants' tissue-sodium concentrations. Gregarious larvae of the bordered patch butterfly, Chlosyne lacinia, cannibalized siblings when plant-tissue sodium concentrations were low in two separate experiments. Although cannibalism was almost non-existent when sodium concentrations were high, individual mortality rates were also high. Sodium concentration in host plants can have pronounced effects on herbivore behaviour, individual-level performance, and population demographics, all of which are important for understanding the ecology and evolution of plant-animal interactions across a heterogeneous phytochemical landscape.