bluuebunny/crossref_metadata_2025_split huggingface dataset:
EFECTO DE LA CURVATURA ESPACIAL DEL UNIVERSO EN EL ESPECTRO ANGULAR DE LAS ANISOTROPÍAS EN LA TEMPERATURA DE LA RADIACIÓN CÓSMICA DE FONDO
Authors: Mariño Gabriel A. , Rodríguez Yeinzon 
Published: December 2023

El paradigma inflacionario resuelve los tres problemas clásicos de la cosmología estándar: el pro­blema de planitud, el problema de horizonte y el problema de las reliquias no deseadas. En particular el problema de planitud se resuelve al explicar cómo la contribución relativa de la curvatura espacial del Universo a la densidad total de energía decrece exponecialmente durante inflación. Además, el escenario inflacionario nos ofrece un mecanismo eficiente para generar pequeñas perturbaciones en la curvatura espacial que explicarían las anisotropías en la temperatura de la radiación cósmica de fondo (RCF) observadas hoy en día. Los tradicionales modelos inflacionarios que desprecian la contribución relativa reproducen las recientes observaciones del satélite WMAP sobre el espectro angular C1 de las anisotropías en la temperatura de la RCF, excepto para los multipolos más pequeños, y especialmente para el cuadrupolo (l = 2) en el cual el valor observado presenta una inesperada caída. Este extraño comportamiento nos conduce a análizar el espectro angular C1 a grandes escalas (pequeños multipolos) teniendo en cuenta la contribución relativa. De esta manera determinamos el tipo de curvatura característica del Universo observado más favorecida por los datos observacionales concernientes al cuadropolo.
ESTIMACIÓN DEL ESPECTRO MULTIFRACTAL PARA SERIES DE PRECIPITACION HORARIA EN LOS ANDES TROPICALES DE COLOMBIA
Authors: Gómez Jesús D. , Poveda Germán 
Published: December 2023

El espectro multifractal f(α) fue estimado para registros de precipitación horaria en 47 estaciones; ubicadas en los Andes; tropicales de Colombia mediante cinco metodologías distintas. Cada una de las metodologías fue aplicada a series provenientes de medidas bi­nomiales, de las cuales se conoce su espectro multifractal teórico. Los resultados permiten concluir que: (i) todas las metodologías presentan resultados satisfactorios en la estimación de f(α) para las medidas binomiales sintéticas (ii) las cinco metodologías presentan estima­ciones muy diferentes del espectro para las series temporales de lluvia a escala horaria (iii) se encuentra valores muy variables de la fuerza multifractal, Δα, variando desde 0.66 a 7.4 (iv) el exponente de Renyi, T(q), pude ser representado por un modelo simple, basado en la generalización de un modelo de cascadas multiplicativas (v) No se encontró una relación clara entre los parámetros encontrados en este trabajo y la elevación. Finalmente se presenta una discusión en torno a las características de los modelos y los problemas de estimación en series de lluvia a resolución horaria.
HISTOLOGÍA COMPARADA DEL SISTEMA REPRODUCTIVO DE CUATRO ESPECIES DE RAYAS CARIBEÑAS (CHONDRICHTHYES: BATOIDEA)
Authors: Acero P Arturo , Grijalba-Bendeck Marcela , Moreno Fabián , Acevedo Kelly , González Esperanza 
Published: December 2023

Con el fin de comparar histológicamente los sistemas reproductivos de diferentes linajes de batoideos se examinaron 93 ejemplares (62 hembras y 31 machos) de cuatro especies: Narcine bancroftii (familia Narcinidae), Rhinobatos percellens (familia Rhinobatidae), Urotrygon venezuelae (familia Urotrygonidae) y Dasyatis guttata (familia Dasyatidae). Se diferenciaron tres tipos de sistemas femeninos: R. percellens ejemplifica un sistema generalizado; U. venezuelae y D. guttata muestran un ovario que alberga ovocitos con estructuras internas únicas; N. bancroftii posee el ovario más derivado, en cuanto a la presencia y forma de estructuras exclusivas. Sin embargo, al ser las características claramente autapomórficas no es posible plantear hipótesis de relaciones a partir de los sistemas femeninos. Las diferencias son relativamente menos profundas en los sistemas masculinos, con N. bancroftii mostrando un testículo generalizado, mientras R. percellens presenta cierto grado de lobulación externa; D. guttata presenta un testículo de tipo Radial, que en U. venezuelae aparece modificado.
TIRADS ve bethesda sınıflandırmaları kullanılarak tiroid nodülünün ultrason ve sitolojik tanısının korelasyonu
Authors: YAKUPOĞLU Abdullah 
Published: December 2023

Amaç: Tiroid nodülü olan bireylerin ilk değerlendirmesinde kullanılan iki tanı yöntemi TIRADS ve Bethesda sistemleri arasındaki uyumu değerlendirmektir.
Gereç ve Yöntemler: Ocak 2020 ve Aralık 2022 yılları arasında tek bir girişimsel radyolog tarafından US kılavuzluğunda yapılan 414 tiroid nodüllü hastaya yapılan İİA biyopsileri retrosepektif olarak incelendi. Hastaların demografik bilgileri, nodüllerin boyutu, ekojenitesi ve kontur durumu, TIRADS ve BETHESDA skorları kaydedildi ve analiz edildi.
Bulgular: Çalışma popülasyonunun ortalama yaşı 50.4 ± 14.2 idi ve çoğunluğu kadın hastalardı (%74.9). Hastaların ortalama nodül boyutu 18.36 ± 12.96 mm olarak ölçüldü. Tiroid nodülleri TRIADS kriterlerine göre sınıflandırıldığında 29 (%7) hastada TIRADS TR2, 147 (%35.5) hastada TIRADS TR3, 166 (%40.1) hastada TR4 ve 72 (%17.4) hastada TR5 idi. TIRADS 2, 3, 4 ve 5 sınıflarında Bethesda Class V ve Class VI olasılığı sırasıyla %0, %3.4, 31.3 ve %66.7 idi. TIRADS kategori 2'de Bethesda Sınıf II olasılığı %100 iken, TIRADS 3, 4 ve 5 sınıfları için sırasıyla %81.6, %34.9 ve %25 idi.
Sonuçlar: Çalışmamız, tiroid nodülü İİAS'nin Bethesda Sınıflandırması ile TIRADS sınıflandırmasını kullanan tiroid ultrason raporlaması arasında oldukça iyi bir korelasyon olduğunu göstermektedir. İki bulgunun doğru yorumlanması, klinisyenin tiroid kanseri gösterme olasılığı düşük olan hastalarda gereksiz invaziv prosedür riskini azaltmasına yardımcı olurken, yüksek kanser riski taşıyan hastaların belirlenmesini kolaylaştırır.
Encapsulation of Jeruju Leaves Ethanol Extract (Acanthus ilicifolius L.) and It's Antiinflammatory Activities Against Carrageenan-Induced Mice
Authors: Tarigan Indra Lasmana , Kharisma Tiara , Bemis Restina , Sutrisno Sutrisno , Latief Madyawati 
Published: December 2023

Jeruju (Acanthus ilicifolius) leaves ethanol extract contains flavonoids that function as an antiinflammatory source. So it is necessary to research to increase the utilization of ethanol extract of Acanthus ilicifolius leaves (A. ilicifolius L.) in encapsulations to increase the stability of antiinflammatory chemical compounds. Concentrated dyestuff extracts are often unstable, so they need to be converted into solid form, and one technique that can be done is encapsulation. Encapsulation aims to protect sensitive components of the material and reduce the degradation of active compounds in the material. The research method begins with preparing samples to be extracted with ethanol solvent, extract phytochemical screening tests, validation determination tests for the analysis method of ethanol extract levels of jeruju leaves, encapsulated formulations, encapsulated physics and chemical properties test and anti-inflammatory tests. In this research, the secondary metabolite compounds contained in the ethanol extract of Jeruju Leaves were flavonoids, phenolics, steroids, and saponins. The determination of the validation of the analysis method of ethanol extract levels of jeruju leaves was obtained by measurement using a UV-vis spectrophotometer and obtained extract levels of 1367,831 mg/g. This research used maltodextrin coating material for encapsulation formulation because it has low viscosity in many ratios, high solubility, has no taste. The freeze-dryer method was used in this study because it produces better drying quality than other drying methods. The physical property test was carried out by analysis using FTIR and SEM while the chemical properties of encapsulation obtained the highest yield proportion of 58.81%, and the highest solubility proportion of 98.76%. Anti-inflammatory testing is carried out using male mice as test animals. Anti-inflammatory testing in mice based on the Rat hind paw oedema method. The average percent inhibition of each dose administered is calculated based on the data results. The high average percent inhibition obtained for Diclofenac Na is 80%. In the research Encapsule 1:12, the 120 mg/KgBW dose had a significant percentage of inhibition of 75.55%, with Na Diclofenac dose of 10 mg/KgBW being 80%.
Authors: Botahala Loth 
Published: December 2023

Abstract – Health is a state of health, both physically, mentally, spiritually and socially that enables everyone to live socially and economically productive lives. Good immune system can prevent infection from various viruses. Kitchen spices are types of plants that are included in the category of plants/medicinal plants/herbs that have efficacy as drugs for healing and preventing various diseases. The use of kitchen spices as medicine/herbs has not been widely practiced by the community, especially the people in Luba Village, Lembur District, Alor Regency, due to the limited knowledge of the community about its use to increase immune power. The purpose of this community service activity is to provide knowledge about the importance of recognizing natural ingredients that can be used as herbs and how to make and use ingredients from these kitchen spices as herbal ingredients that can be consumed to maintain body resistance against various occupational diseases. The results of this community service activity show that the people of Luba Village, Lembur District, Alor-NTT Regency have gained knowledge about the content and benefits of turmeric, ginger, lemongrass, and brown sugar, as well as lime for health as well as having gained knowledge and practice on how to make herbs. and together enjoy the results of making these herbs.

Keywords:
Genetically modified MSCs into neuraland endothelial cell-like cells inducedby a branched peptide amphiphile hydrogel
Authors: Yin Peiyi , Zeng Zhihua , Li Yixiu , Zhou Tiantian , Wu Kai , song yulin 
Published: December 2023

Abstract
Background： Spinal cord injury (SCI) remain one of the great clinical challenges because of their considerable long-term disability potential. In this study, A branched amphiphilic peptide (B-PA) segments were constructed and self-assembled into hydrogels to support bone marrow derived mesenchymal stromal cells (BMSCs) encoding Recombinant Rat VEGF165（VEGF165）, neurotrophins-3(NT-3)and angiopoietin-1(ANG-1) genes. In addition, B-PAS promoted the transdifferentiation of BMSCs into nerve and vascular endothelial cells.
Methods：Self-assembly of b-PA into a nanofiber hydrogel was triggered by the culture medium and analysed by transmission electron microscopy (TEM). Rat BMSCs were cultivated using the differential adhesion method and assessed by flow cytometry. Cells were inoculated into the hydrogel and investigated using calcein-AM/PI, CCK-8, and cell adhesion assays. Cells transfected with adenoviral vectors of biocarrier (Adv-Bic) and adenoviral vectors of NT-3 gene (AdvNT-3) were cultured for 7 days and evaluated by immunofluorescence and real time quantitative reverse transcription-PCR.
Results：The molecular weight and purity of b-PA were 2191.72 and >95%, respectively. Self-assembled nanofibers had a diameter of 5-8 nm and a length ranging from hundreds of nanometres to micrometres. The resulting CD29+/44+ cells could differentiate into osteoblasts and fat cells, and the hydrogel supported cell growth, proliferation and adhesion. Cells in the hydrogel overexpressed VEGF165, NT-3 and Ang-1, and NSE and Nestin markers of CD31+/34+ cells were also abundant.
Conclusions： The hydrogel has potential as a tissue engineering scaffold with good cytocompatibility, and can induce genetically modified BMSCs to transdifferentiate into neural and endothelial cell (EC)-like cells. The article have selected preprint on the research platform, this article has been assigned a DOI, The DOI is:10.21203/rs.3.rs-1822746/v1.
Evaluating the population-based utilization and benefit of digitally collected patient-reported outcomes and experiences in patients with chronic diseases: The PROMchronic study protocol
Authors: Nikkhah Janis , Steinbeck Viktoria , Grobe Thomas , Breitkreuz Thorben , Pross Christoph , Busse Reinhard 
Published: December 2023

Abstract
Background
Chronic diseases are associated with a high disease burden. Under- and overprovision of care as well as quality variation between healthcare providers persists, while current quality indicators rarely capture the patients’ perspective. Capturing patient-reported outcome measures (PROMs) as well as patient-reported experience measures (PREMs) is becoming more and more important to identify gaps in care provision, prioritize services most valuable to patients, and aid patients' self-management.
Methods
This prospective cohort study aims to evaluate the potential benefits of PROM usage in patients with chronic diseases. We evaluate whether (1) digitally collected PROMs and PREMs can be used for health system performance assessment (HSPA) by generating a representative response of chronically diseased individuals with asthma, chronic obstructive pulmonary disease (COPD), diabetes, and coronary artery disease (CAD) across Germany and (2) whether, based on the PROMs and PREMs, low-value care can be identified. As patient-reported outcomes (PROs) are rarely presented back to patients, (3) this study also examines patients’ reactions to their PROM scores in the form of digital PRO feedback. For these purposes, randomly selected patients from a nationwide German insurer are digitally surveyed with generic and disease-specific PROMs and PREMs as well as additional questions on their health-related behavior four times over one year. Individual PRO feedback is presented back to patients longitudinally and compared to a peer group after each survey period. Patient-reported data is linked with health insurance data. Response rates, changes in health and experience outcomes over time, self-reported changes in health behavior, and healthcare system utilization will be analyzed.
Discussion
We aim to fill the research gap on the population-based utilization of PROMs and PREMs in patients with chronic diseases and add to the current understanding of PROM data-sharing with patients. The study’s results can thereby inform whether a healthcare system-wide approach of collecting PROMs and PREMs can be utilized to identify low-value care, assess quality variation within and across chronic conditions, and whether PRO feedback is helpful and associated with any changes in patient’s health behaviors.
Trial registration
German Clinical Trials Register - DRKS00019916. Registration date: August 22, 2023.
Anterior cervical corpectomy and fusion-derived adjacent segment disease managed via channel-repairing anterior endoscopic transcorporeal cervical discectomy: A case report
Authors: Qin Jianpu , Qian Hu , Xin Zhijun , Liu Guangyi , Jun Ao , Liao Wenbo 
Published: December 2023

Abstract

Background: Management of anterior cervical corpectomy and fusion (ACCF)-derived adjacent segment disease (ASD) represented a challenge facing the surgeons.
Methods: A 41-year man diagnosed as C3-4 level ASD derived from C5-level ACCF surgery 13 years ago was admitted to the hospital for numbness and pain in the right shoulder and upper limb. Percutaneous full-endoscopic anterior transcorporeal cervical discectomy (PEATCD) was performed, and pre- and postoperative clinical and imaging data were collected.
Results: The operation was completed within 70 min, and no clinical or radiological complication was reported. The visual analog scale (VAS) score decreased from preoperative 5 points to postoperative 1 point. Numbness was relieved postoperatively and disappeared completely at postoperative 3 months. Imaging data indicated sufficient spinal cord decompression, good channel repairing and cervical alignment.
Conclusions: Channel-repairing PEATCD was successfully performed to treat ACCF-derived ASD, which could be an effective and minimally invasive option for ACCF-derived ASD.
Cultural-Responsiveness of the Mental Health First Aid Training for Asian Immigrant Populations in Greater Boston, Massachusetts
Authors: Kim Min Kyung , Su Grace S. , Chan Angel N.Y. , Fu Yuxin , Huang Yanqing , Huang Chien-Chi , Hires Ben , Chu MyDzung 
Published: December 2023

Abstract

Background
The COVID-19 pandemic and rise in anti-Asian racism have had adverse mental health impacts in Asian communities. The lack of culturally-responsive and linguistically-accessible mental health trainings hinders access to mental health services for Asian populations. In this study, we assessed the mental health needs of Asian communities in Greater Boston and evaluated cultural responsiveness of the Mental Health First Aid (MHFA), a first-responder training teaching participants skills to recognize signs of mental health and substance use challenges, and how to appropriately respond.
Methods
This community-based participatory research with the Boston Chinatown Neighborhood Center (BCNC), Asian Women For Health (AWFH), and the Addressing Disparities in Asian Populations through Translational Research (ADAPT) Coalition employed two phases. In phase 1, we conducted focus groups with BCNC and AWFH staff and peer educators to assess mental health priorities of Asian populations in Boston. Findings informed phase 2, which evaluated cultural responsiveness of the MHFA through pre- and post-training questionnaires and focus groups with community participants. The pre-training questionnaire asked about mental health needs and barriers, help-seeking behaviors, and literacy; and personal and Asian community stigma. The post-training questionnaire and focus group with community participants asked about cultural competence of MHFA training for Asian populations. Paired t-tests were used to evaluate questionnaire responses. Thematic analysis was used to analyze interviews.
Results
In total, 10 staff/educators and 8 community members participated in focus groups. They identified common mental health needs and workforce and culturally-responsive community strategies to support persons with mental health issues. Twenty-four community participants completed pre- and post-training questionnaires. They reported the MHFA training reduced mental health care stigma and increased mental health literacy. Recommendations to increase cultural-responsiveness of the MHFA were to include mental health case studies common in Asian populations and provide the training in other languages (e.g., Chinese, Vietnamese).
Conclusion
Cultural responsiveness of the MHFA for Asian populations could be improved with the inclusion of case studies specific to the Asian communities and accessibility of the training in other languages. Increasing the cultural relevance and language accessibility of these trainings could help reduce mental health stigma and gaps in mental health awareness and service utilization among Asian populations.
Adoption of multiple strategies to reduce the rate of marker detachment during radiotherapy in patients with cancer
Authors: Yang Huei-Fan , Tsai Hsueh-Ya , Chou Ying-Hsiang , Hsieh Yu-Chen , Li Shao-Ti , Huang Hsiao-Ju , Ke Ya-Fang , Tsai Pei-Fang , Chan Hsiu-Man , Lee Yueh-Chun 
Published: December 2023

Abstract

Background: In the process of radiation therapy, the patient’s body surface needs to be marked as the basis for treatment positioning. The positioning mark may fade or disappear during the treatment because of various factors, which will not only affect the accuracy of the treatment, but also increase the time and cost of medical treatment if the mark needs to be re-established. For patients, it can reduce the time spent on the treatment table and decrease the anxiety level associated with waiting for treatment.
Purpose: For family members: To shorten the time spent in treatment and reduce the disturbance of family members accompanying the examination. For patients: To increase the patient’s satisfaction with the assistance of the radiation oncology staff in completing treatment. For hospitals: To reduce the cost of labor and materials.
Methods: From January to June, the main causes of the disappearance or fading of surface markers in patients treated with radiation therapy were identified. Patients who dropped out of the treatment were annotated on the Medical System for Radiation Oncology (MOSAIQ), to keep track of them. We used our in-house-designedradiotherapy red and green light markers to distinguish individual measures after the provision of the initial nursing care to new patients, added a homemade health education leaflet to collect data via actual observation, and counted the disappearance or fading of patients’ body markers. The effectiveness of the dropout was analyzed, and the improvement measures to reduce dropout were incorporated into the clinical care and health education routine, to improve the accuracy of treatment and ensure the quality and safety of patient treatment.
Conclusions: Marker repositioning on the treatment table decreased significantly after the improvement, from 82 instances totaling 1,230 min (average,102.5 min/month) to seven instances totaling 70 min (average, 23.4 min/month). Moreover, the anxiety level while waiting for treatment decreased from 5 points to 3 points (Beck Anxiety Inventory). In the future, the improvement plan can be incorporated into the routine process of radiation oncology, which will not only reduce the time and cost of medical treatment, but also improve its accuracy, to ensure the quality and safety of patient treatment.
Trial Registration
ClinicalTrials.gov Identifier: NCT06132295
Structural dynamics of GluK2 kainate receptors in apo and partial agonist bound states.
Authors: Tajima Nami , Bogdanović Nebojša , Segura-Covarrubias Guadalupe , Zhang Lisa 
Published: December 2023

Abstract
Kainate receptors (KARs) belong to the family of ionotropic glutamate receptors (iGluRs) and are tetrameric ligand-gated ion channels that regulate neurotransmitter release and excitatory synaptic transmission in the central nervous system. While KARs share overall architectures with other iGluR subfamilies, their dynamics are significantly different from those of other iGluRs. KARs are activated by both full and partial agonists. While there is less efficacy with partial agonists than with full agonists, the detailed mechanism has remained elusive. Here, we used cryo-electron microscopy to determine the structures of homomeric rat GluK2 KARs in the absence of ligands (apo) and in complex with a partial agonist. Intriguingly, the apo state KARs were captured in desensitized conformation. This structure confirms the KAR desensitization prior to activation. Structures of KARs complexed to the partial agonist domoate populate in domoate bound desensitized and non-active/non-desensitized states. These previously unseen intermediate structures highlight the molecular mechanism of partial agonism in KARs. Additionally, we show how N-glycans stabilized the ligand-binding domain dimer via cation/anion binding and modulated receptor gating properties using electrophysiology. Our findings provide vital structural and functional insights into the unique KAR gating mechanisms.