bluuebunny/crossref_metadata_2025_split huggingface dataset:
Thermo-solutal Marangoni convective Darcy-Forchheimer bio-hybrid nanofluid flow over a permeable disk with activation energy: Analysis of interfacial nanolayer thickness
Authors: Mohanty D. , Mahanta G. , Byeon Haewon , Vignesh S. , Shaw S. , Khan M. Ijaz , Abduvalieva Dilsora , Govindan Vediyappan , Awwad Fuad A. , Ismail Emad A. A. 
Published: October 2023

Abstract
The Marangoni convective phenomena have a unique impact on industries and medical tools. These phenomena are more prominent in the presence of dual nanoparticles (NPs) over base fluids such as blood that are surrounded by a thin interfacial nanolayer, an important feature to control the physical and thermal properties of the NP. In this problem, we have analysed the thermo-solutal Marangoni convective Darcy-Forchheimer flow of nanomaterials with the impact of the interfacial nanolayer. The results of the system of an exponential heat source, non-linear radiation, joule heating, and activation energy are discussed. An appropriate transition is applied to rationalise the substantially paired and nonlinear governing equations and then processed by the Galerkin finite element method (G-FEM). The impression of different governing parameters on the governing systems in conjunction with entropy and Bejan number is demonstrated through graphical and tabular form. Graphs are drawn with an evaluation of general and hybrid nanofluids (HNFs) and different nanolayer thicknesses of NPs. Activation energy and chemical reaction parameters restrict the Sherwood number, and the same is observed for the Nusselt number with an increase in the Brinkman and Eckert numbers. The thickness of the interfacial nanolayer of the NPs restricts the entropy generation of the system, while the entropy is higher for the HNF than the nanofluid. An opposite feature was observed for the Bejan number.
Dynamic Changes in Local Activity and Network Interactions among the Anterior Cingulate, Amygdala, and Cerebellum during Associative Learning
Authors: Halverson Hunter E. , Kim Jangjin , Freeman John H. 
Published: October 2023

Communication between the cerebellum and forebrain structures is necessary for motor learning and has been implicated in a variety of cognitive functions. The exact nature of cerebellar–forebrain interactions supporting behavior and cognition is not known. We examined how local and network activity support learning by simultaneously recording neural activity in the cerebellum, amygdala, and anterior cingulate cortex while male and female rats were trained in trace eyeblink conditioning. Initially, the cerebellum and forebrain signal the contingency between external stimuli through increases in theta power and synchrony. Neuronal activity driving expression of the learned response was observed in the cerebellum and became evident in the anterior cingulate and amygdala as learning progressed. Aligning neural activity to the training stimuli or learned response provided a way to differentiate between learning-related activity driven by different mechanisms. Stimulus and response-related increases in theta power and coherence were observed across all three areas throughout learning. However, increases in slow gamma power and coherence were only observed when oscillations were aligned to the cerebellum-driven learned response. Percentage of learned responses, learning-related local activity, and slow gamma communication from cerebellum to forebrain all progressively increased during training. The relatively fast frequency of slow gamma provides an ideal mechanism for the cerebellum to communicate learned temporal information to the forebrain. This cerebellar response-aligned slow gamma then provides enrichment of behavior-specific temporal information to local neuronal activity in the forebrain. These dynamic network interactions likely support a wide range of behaviors and cognitive tasks that require coordination between the forebrain and cerebellum.SIGNIFICANCE STATEMENTThis study presents new evidence for how dynamic learning-related changes in single neurons and neural oscillations in a cerebellar–forebrain network support associative motor learning. The current results provide an integrated mechanism for how bidirectional communication between the cerebellum and forebrain represents important external events and internal neural drive. This bidirectional communication between the cerebellum and forebrain likely supports a wide range of behaviors and cognitive tasks that require temporal precision.
Accentuated Paralimbic and Reduced Mesolimbic D2/3-Impulsivity Associations in Parkinson's Disease
Authors: Stark Adam J. , Song Alexander K. , Petersen Kalen J. , Hay Kaitlyn R. , Lin Ya-Chen , Trujillo Paula , Kang Hakmook , Collazzo Jenna M. , Donahue Manus J. , Zald David H. , Claassen Daniel O. 
Published: October 2023

Impulsivity is a behavioral trait that is elevated in many neuropsychiatric disorders. Parkinson's disease (PD) patients can exhibit a specific pattern of reward-seeking impulsive-compulsive behaviors (ICBs), as well as more subtle changes to generalized trait impulsivity. Prior studies in healthy controls (HCs) suggest that trait impulsivity is regulated by D2/3autoreceptors in mesocorticolimbic circuits. While altered D2/3binding is noted in ICB+PD patients, there is limited prior assessment of the trait impulsivity–D2/3relationship in PD, and no prior direct comparison with patterns in HCs. We examined 54 PD (36 M; 18 F) and 31 sex- and age-matched HC (21 M; 10 F) subjects using [18F]fallypride, a high-affinity D2/3receptor ligand, to measure striatal and extrastriatal D2/3nondisplaceable binding potential (BPND). Subcortical and cortical assessment exclusively used ROI or exploratory-voxelwise methods, respectively. All completed the Barratt Impulsiveness Scale, a measure of trait impulsivity. Subcortical ROI analyses indicated a negative relationship between trait impulsivity and D2/3BPNDin the ventral striatum and amygdala of HCs but not in PD. By contrast, voxelwise methods demonstrated a positive trait impulsivity–D2/3BPNDcorrelation in ventral frontal olfactocentric-paralimbic cortex of subjects with PD but not HCs. Subscale analysis also highlighted different aspects of impulsivity, with significant interactions between group and motor impulsivity in the ventral striatum, and attentional impulsivity in the amygdala and frontal paralimbic cortex. These results suggest that dopamine functioning in distinct regions of the mesocorticolimbic circuit influence aspects of impulsivity, with the relative importance of regional dopamine functions shifting in the neuropharmacological context of PD.SIGNIFICANCE STATEMENTThe biological determinants of impulsivity have broad clinical relevance, from addiction to neurodegenerative disorders. Here, we address biomolecular distinctions in Parkinson's disease. This is the first study to evaluate a large cohort of Parkinson's disease patients and age-matched healthy controls with a measure of trait impulsivity and concurrent [18F]fallypride PET, a method that allows quantification of D2/3 receptors throughout the mesocorticolimbic network. We demonstrate widespread differences in the trait impulsivity–dopamine relationship, including (1) loss of subcortical relationships present in the healthy brain and (2) emergence of a new relationship in a limbic cortical area. This illustrates the loss of mechanisms of behavioral regulation present in the healthy brain while suggesting a potential compensatory response and target for future investigation.
Canalisation and plasticity on the developmental manifold of Caenorhabditis elegans
Authors: Jordan David J , Miska Eric A 
Published: October 2023

AbstractHow do the same mechanisms that faithfully regenerate complex developmental programmes in spite of environmental and genetic perturbations also allow responsiveness to environmental signals, adaptation and genetic evolution? Using the nematode Caenorhabditis elegans as a model, we explore the phenotypic space of growth and development in various genetic and environmental contexts. Our data are growth curves and developmental parameters obtained by automated microscopy. Using these, we show that among the traits that make up the developmental space, correlations within a particular context are predictive of correlations among different contexts. Furthermore, we find that the developmental variability of this animal can be captured on a relatively low‐dimensional phenotypic manifold and that on this manifold, genetic and environmental contributions to plasticity can be deconvolved independently. Our perspective offers a new way of understanding the relationship between robustness and flexibility in complex systems, suggesting that projection and concentration of dimension can naturally align these forces as complementary rather than competing.
From qualitative to quantitative: the state of the art and challenges for plant synthetic biology
Authors: Tian Chenfei , Li Jianhua , Wang Yong 
Published: October 2023

The flourishing plant science promotes the exploding number of data and the expansion of toolkits. Plant synthetic biology is still in its early stages and requires more quantitative and predictable study. Despite the challenges, some pioneering examples have been successfully demonstrated in model plants.BackgroundsAs an increasing number of synthetic switches and circuits have been created for plant systems and of synthetic products produced in plant chassis, plant synthetic biology is taking a strong foothold in agriculture and medicine. The ever‐exploding data has also promoted the expansion of toolkits in this field. Genetic parts libraries and quantitative characterization approaches have been developed. However, plant synthetic biology is still in its infancy. The considerations for selecting biological parts to design and construct genetic circuits with predictable functions remain desired.ResultsIn this article, we review the current biotechnological progresses in field of plant synthetic biology. Assembly standardization and quantitative approaches of genetic parts and genetic circuits are discussed. We also highlight the main challenges in the iterative cycles of design‐build‐test‐learn for introducing novel traits into plants.ConclusionPlant synthetic biology promises to provide important solutions to many issues in agricultural production, human health care, and environmental sustainability. However, tremendous challenges exist in this field. For example, the quantitative characterization of genetic parts is limited; the orthogonality and the transfer functions of circuits are unpredictable; and also, the mathematical modeling‐assisted circuits design still needs to improve predictability and reliability. These challenges are expected to be resolved in the near future as interests in this field are intensifying.
Comprensión de oraciones con cláusulas relativas en niños de 6 a 11 años hablantes del español rioplatense
Authors: Zamora Dolores , Barreyro Juan-Pablo , Sánchez María-Victoria , Martínez-Cuitiño Macarena 
Published: October 2023

La comprensión de oraciones relativas ha sido el objeto de numerosas investigaciones en la población infantil, pero pocas logran establecer la etapa en la que se adquieren y los estudios en español son escasos. El objetivo de esta investigación es comparar el desempeño de niños hablantes de español rioplatense en la comprensión de oraciones relativas. Para ello, 105 niños de tres grupos etarios: 6-7, 8-9 y 10-11 años, respectivamente, fueron evaluados una tarea de comprensión oral de oraciones relativas de sujeto y de objeto. Los resultados muestran diferencias significativas en el rendimiento de los grupos. Los niños de todas las edades tienen dificultades para comprender oraciones relativas de objeto, mientras que el desempeño en oraciones relativas de sujeto varía según la posición en la que se encuentra incrustada la cláusula subordinada.
How Do Teachers Differentiate Instruction Through Materials in a Colombian Rural Zone?
Authors: Castiblanco Valentina , Pelaez Laura , Santana Melany , Tibaná Danna 
Published: October 2023

This research study aims to investigate how teachers implement strategies of differentiated instruction through materials in their classrooms by taking into consideration the diverse students’ profiles. In this phenomenological qualitative article a total of six (6) EFL educators from Pensilvania (Caldas) participated in this investigation, and data was collected through class observations and semi-structured interviews. The results explore the teachers' level of understanding about differentiation, the training they had received on materials' development and the variety of resources provided for each institution, the aspects they contemplate when creating/designing and adapting materials, and the way in which differentiation through materials was carried out in the classroom. In the conclusion of the article, the importance of providing teachers with the necessary resources is emphasized, as well as the necessity for professional development opportunities, and ongoing support to help them meet the student’s needs.
Outcomes of Surgical Treatment for Localized Tenosynovial Giant-Cell Tumor of the Foot and Ankle: A Case Series
Authors: Ipponi Edoardo , Ruinato Alfio Damiano , Lombardi Leonardo , Cordoni Martina , De Franco Silvia , D'Arienzo Antonio , Andreani Lorenzo 
Published: October 2023

Background: Giant cell tumor of the tendon sheath (GCTTS), also termed Tenosynovial giant cell tumor (TGCT), is a locally aggressive tumor which originates from tendon sheaths or bursas. Around 3–5% of these tumors arise from foot and ankle. Localized lesions in this area are often manifested as firm masses or nodules with slow but continuous progression through months and years. Pain associated with weight-bearing, as well as limitations in joint motions, may be reported, depending on tumor’s location. Surgery is the treatment of choice for the definitive removal of GCTTSs with the aim to eradicate the neoplasm and restore the lower limb’s functionality.Methods: Thirteen cases suffering from GCTTS of the foot and ankle underwent surgical resection at our institution between 2017 and 2022. For each case we recorded pre-operative and post-operative symptoms, as well as their pre-operative and post-operative functional status according to both MSTS and AOFAS scores. Eventual complications and local recurrences were reported.Results: Each patient experienced an at least mild pain before surgical treatment. The mean pre-operative MSTS and AOFAS scores were 22.8 and 70.7, respectively. The mean tumor size was 17.7 mm. Each patient received a resection with wide margins. Two cases (15.4%) had local recurrences. None had major complications at their latest follow-up. After the surgery, the mean post-operative MSTS and AOFAS scores increased to 28.3 and 92.2, respectively.Conclusion: Resection with wide margins for foot and ankle GCTTS is effective in restoring the patients’ lower limb functionality and is associated with reasonable local recurrence rates.
Leaving the Dream Behind: Why the Metaphysics of Consciousness cannot be Unveiled by Conceivability Arguments
Authors: Murillo-Lara Luis Alejandro 
Published: October 2023

In this paper, I present a novel objection to Chalmers’s “master argument” against the privileged strategy of ‘type B’ physicalists to account for the explanatory gap (the “phenomenal concepts strategy”). Specifically, I argue that the second horn of the master argument gets wrong why zombies cannot have our epistemic situation with regard to consciousness. Zombies cannot have a kind of mental state that we have. If something must have all of our psychological attributes to share our epistemic situation, then zombies cannot serve the purpose of the second horn of the dilemma. By way of background, I begin by briefly outlining a related argument against physicalism, also advanced by D. Chalmers – the “conceivability argument.” I highlight some of the primary challenges with this argument and present additional criticisms. Finally, through a brief examination of panprotopsychism, I consider what lies ahead if Chalmers’s arguments are conceded. I conclude that the phenomenal concept strategy is a sound explanation for why the conceivability of zombies likely does not imply their metaphysical possibility.
Inhibitory effect of theaflavin-3,3′-digallate can involve its binding to the “stem” domain of α-hemolysin of Staphylococcus aureus
Authors: Goc Anna , Sumera Waldemar , Rath Matthias , Niedzwiecki Aleksandra 
Published: October 2023

AbstractInfections caused by Staphylococcus aureus are currently a worldwide threat affecting millions of individuals. The pathogenicity of S. aureus is associated with numerous virulence factors, including cell surface proteins, polysaccharides, and secreted toxins. The pore-forming α-hemolysin, known as α-toxin, is produced by nearly all virulent strains of S. aureus and is implicated in several diseases including skin and soft tissue infections, atopic dermatitis, and pneumonia. There are currently no vaccines available for the prevention of S. aureus infections and the efficacy of available antibiotics has been fading. In this study we examined the mode of antihemolytic activity of theaflavin-3,3′-digallate against α-hemolysin of methicillin-resistant S. aureus by molecular docking using AutoDock Vina as the molecular docking tool. The theaflavin-3,3′-digallate docked the molecular sequence of the Hla (PDB ID:7ahl). The scores of the top 10 binding modes obtained were between −9.0 and −8.5 kcal mol−1, and the best binding mode was −9.0 kcal mol−1. Direct binding sites of theaflavin-3,3′-digallate to the “stem” domain of Hla were revealed which primarily targeted of the residues Met113, Thr117, Asn139. The disclosure of this potential binding mode warrants further clinical evaluation of theaflavin-3,3′-digallate as an anti-hemolytic compound in order to practically validate our results.
A haemophagocytás lymphohistiocytosis jellemzőinek, diagnosztikájának és kezelési lehetőségeinek áttekintése egy T-sejtes lymphomás beteg bemutatása kapcsán
Authors: Számel Anna , Földeák Dóra Melinda , Modok Szabolcs , Krenács László , Bagdi Enikő , Borbényi Zita 
Published: October 2023

BevezetésA haemophagocytosis egy agresszív, életet veszélyeztető, megfelelő kezelés ellenére is gyakran halálos kimenetelű kórkép, melyben az immunrendszer túlzott aktivációja a haemopoietikus sejtek pusztulásához vezet. A kórkép kiváltó tényezője lehet többek között bármilyen malignus betegség, infekció, valamint szerzett vagy örökölt immunhiányos állapot jelenléte. Általában akut lázas kórkép formájában jelentkezik, többszervi érintettséggel. A leggyakoribb klinikai tünetei a láz, hepatosplenomegalia, cytopenia, májfunkciós eltérések, alvadási zavarok, emelkedett triglicerid, ferritin és laktát-dehidrogenáz szint. A diagnosztikai kritériumok a fentiek mellett tartalmazzák a csontvelő biopsziát és különböző immunológiai teszteket is.EredményekA diagnózis felállítását, illetve a kezelési lehetőségeket egy agresszív citotoxikus T-sejtes lymphoma miatt gondozott betegünk esetén keresztül mutatjuk be. Több vonalbeli kemoterápiás kezelést követően sürgősségi felvételére láz, májelégtelenség miatt került sor. Laborjában emelkedett májfunkciós értékeket, gyulladásos paramétereket, laktát-dehidrogenáz, triglicerid és ferritin szinteket, beszűkült vesefunkciót, valamint anemiát és thrombocytopeniát láttunk. Hasi ultrahang-vizsgálat során hepatosplenomegalia ábrázolódott. A csontvelővizsgálat eredménye pedig a klinikai adatok alapján sejthető haemophagocytosist alátámasztotta, valamint a lymphoma relapszusát mutatta. Elsőként intravénás szteroid- és nagy dózisú vénás immunglobulin-kezelést adtunk. Ezt követően a csontvelő-biopszia eredményének ismeretében a beteg kezelését etopoziddal egészítettük ki, mely mellett a klinikai tünetek és a laborparaméterek jelentős, de csak átmeneti javulását észleltük.KövetkeztetésA haemophagocytosis egy életet veszélyeztető kórkép, ami a T-sejtes lymphomás betegek nehéz sorsát tovább ronthatja. A korai diagnózis és a kiváltó oknak megfelelő kezelés késleltetheti a többszervi elégtelenség kialakulását, ugyanakkor a prognózist a lymphoma lefolyása határozza meg.
Nuevo Gonolobus (Apocynaceae, Asclepiadoideae, Gonolobeae, Gonolobineae) para la Faja Volcánica Transmexicana, Puebla, México
Authors: Alvarado-Cárdenas Leonardo O. , Nuñez-Oberg Marcos Bodo , Islas-Hernández Sofía 
Published: October 2023

Antecedentes: Se realizaron salidas de campo a Puebla y se encontró una planta trepadora perteneciente a Gonolobus que no coincidía morfológicamente con ninguna otra especie del género. Aquí se propone una nueva especie y se compara con las especies de G. cuajayote y G. jaliscensis.
Preguntas: ¿Son nuevas para la ciencia las plantas de Gonolobus colectadas en la Sierra de Tentzo, Puebla? ¿Cómo se distinguen de otras especies del género, cuál es su distribución y estado de conservación?
Especies de estudio: Gonolobus sp. nov.
Sitio y años de estudio: Parque Estatal Sierra del Tentzo, estado de Puebla, México.
Métodos: Se realizó la descripción y análisis morfológico de las plantas. Con base en el concepto cohesivo de especie se comparó con taxones afines y se generó la clave de identificación. Se estableció una categoría de vulnerabilidad para la especie.
Resultados: Gonolobus volcanicus se propone como una especie nueva para México. La especie se distingue por la densa pubescencia de la corola y anillo faucial, la forma de los apéndices dorsales de las anteras, así como por su distribución. Se proporciona la descripción morfológica de la especie nueva, imágenes, mapa de distribución geográfica y estado de conservación. Se incluye una clave de las especies de Gonolobus presentes en Puebla, junto con las especies similares.
Conclusiones: Gonolobus volcanicus se reconoce como una especie nueva para la ciencia. Este descubrimiento incrementa a 46 el número de especies de Gonolobus registradas para el país y representa la primera especie del género endémica de Puebla.
Neuromuscular diseases in intensive care
Authors: Yahya Lahrichi , Ghita Mninou , Ali Derkaoui , Ibrahim Bechri , Abdelkrim Shimi , Mohammed Khatouf 
Published: October 2023

Guillain-Barre syndrome and myasthenia gravis are common in the Intensive Care Unit (ICU) and are not always easy to diagnose in the emergency department. The short-term risk is the occurrence of respiratory muscle paralysis, which must be monitored by repeated measurement of vital capacity, and the existence of respiratory impairment requires transfer to intensive care. Apart from specific therapeutic options (plasma exchange, intravenous immunoglobulins and anticholinesterase agents), management is mainly symptomatic. Our work is a retrospective study, concerning 23 cases of neuromuscular diseases in the ICU from a period from 2018 to 2022. The various epidemiological, clinical, paraclinical, therapeutic, and evolutionary data were collected from the files of the Intensive Care Department A1 of the Hassan II University Hospital of Fez for the study. Osteomas of the paranasal sinuses are benign, often asymptomatic, tumors that progress very slowly. Endocranial development of an osteoma can breach the dura mata, allowing air to enter the cranium producing pneumocephalia which leads to severe neurological deficiencies. Pneumocephalia is an exceptional complication of osteoma.