bluuebunny/crossref_metadata_2025_split huggingface dataset:
Osteology of the sauropodomorph dinosaur Jaklapallisaurus asymmetricus from the Late Triassic of central India
Authors: Ezcurra Martín D. , Müller Rodrigo T. , Novas Fernando E. , Chatterjee Sankar 
Published: December 2023

AbstractThe Gondwana formations exposed in the Pranhita‐Godavari Valley of central India include Middle Triassic to Lower Jurassic continental deposits that provide essential information about the tetrapod assemblages of that time, documenting some of the oldest known dinosaurs and the first faunas numerically dominated by this group. The Upper Maleri Formation of the Pranhita‐Godavari Basin preserves an early‐middle Norian dinosaur assemblage that provides information about the early evolutionary history of this group in central‐south Gondwana. This assemblage comprises sauropodomorph dinosaurs and an herrerasaurian, including two nominal species. Here, we describe in detail the anatomy of one of those early dinosaurs, the bagualosaurian sauropodomorph Jaklapallisaurus asymmetricus. The new anatomical information is used to investigate the position of the species in an updated quantitative phylogenetic analysis focused on early sauropodomorphs. The analysis recovered Jaklapallisaurus asymmetricus as a member of Unaysauridae, at the base of Plateosauria, together with Macrocollum itaquii and Unaysaurus tolentinoi from the early Norian of southern Brazil. This phylogenetic result indicates that the dispersal of early plateosaurian sauropodomorphs between the Southern Hemisphere and what nowadays is Europe would have occurred shortly after Ischigualastian times because of the extension of their ghost lineage. Thus, the presence of early plateosaurians in the early Norian of South America and India reduces a previously inferred diachrony between the biogeographic dispersals of theropods and sauropodomorphs during post‐Ischigualastian times.
At the limits of bisphosphonio‐substituted stannylenes
Authors: Nasemann Sina , Franz Roman , Kargin Denis , Bruhn Clemens , Kelemen Zsolt , Gutmann Torsten , Pietschnig Rudolf 
Published: December 2023

AbstractDonor stabilization of Sn(II) and Pb(II) halides with 1,1’‐ferrocenylene bridged bisphosphanes has been explored for Fe(C5H4P(C6H5)2)2 (dppf), and Fe(C5H4PH(C4H9))2. These bisphosphanes are reacted with SnBr2 and PbCl2 with and without additional Lewis acid (AlCl3) forming acyclic and cyclic donor adducts from which the latter represent bisphosphoniotetrylenes. Since dynamic exchange in solution is observed, characterization includes solution and solid‐state NMR in addition to SC‐XRD, amended by DFT calculations.
Bimetallic Nanoparticles Embedded in P,N,Br‐Codoped Carbon Matrices Derived from Heterometallic‐Organophosphine Frameworks as Electrode Materials for Asymmetric Supercapacitors
Authors: Mahmoud Abdallah G. , Nardeli Jéssica V. , Ferreira Maria João , Ferraria Ana M. , Botelho do Rego Ana M. , Guedes da Silva M. Fátima C. , Pombeiro Armando J. L. 
Published: December 2023

AbstractAn unprecedented method has been developed to obtain heterometallic‐organophosphine frameworks (HMOPFs) through a solvent‐free, three‐component mechanochemical process. In a ball mill, mixing copper (I) bromide with zinc (II), nickel (II) or copper (II) acetates, in the presence of (PTA‐CH2‐C6H4‐p‐COOH) Br (PTA is 1,3,5‐triaza‐7‐phosphaadamantane) as an organic linker, has produced the corresponding HMOPFs based on Cu+‐Zn2+, Cu+‐Ni2+ and Cu+‐Cu2+, respectively. The pyrolysis of HMOPFs resulted in bimetallic nanoparticles of transition metal phosphide and phosphate embedded in multi‐P,N,Br‐codoped carbon matrices (Cu−M@C). Due to the utilization of an aminophosphine organic linker, this HMOPFs‐derived approach typifies an eco‐friendly synthesis of carbon confined transition metal phosphides or phosphates. It avoids the common conventional methods that involves phosphorylation using large amounts of additional P sources, which leads to an intensive release of the flammable and poisonous phosphine gas. Also, the presence of Br at the organic linker eliminates the need for using bromine vapours to obtain halogen‐doped carbon matrices. The Cu−M@C nanocomposites were tested as negative electrode materials for asymmetric supercapacitors. Electrochemical tests included cyclic voltammetry and galvanostatic charge‐discharge experiments, which revealed the Cu−Zn@C electrode with a higher potential window as compared to Cu−Ni@C and Cu−Cu@C electrodes, achieving a rate performance of 60 % and high coulombic efficiency.
Recalculating the Route: Repositioning Antimicrobial Peptides for Cancer Treatment
Authors: de Almeida Gomes Isadora , da Lima Ana Beatriz , da Silva Brito Daiane Maria , Almeida Lima Arlene , de Oliveira Francisco Laio , Espino Zelaya Elmer Adilson , Magalhães Rebello Alencar Luciana , Castelo Branco de Souza Collares Maia Débora , Amaral de Moraes Maria Elisabete , Pantoja Mesquita Felipe , Noronha Souza Pedro Filho , Montenegro Raquel C. 
Published: December 2023

AbstractResistance to antimicrobial drugs has been considered a public health problem. Likewise, the increasing resistance of cancer cells to drugs currently used in therapy has also become a problem. Therefore, the research and development of synthetic peptides bring a new perspective on the emergence of new drugs for treating this resistance since bioinformatics provides a means to optimize these molecules and save time and costs in research. Peptides have several mechanisms of action, such as forming pores on the cell membrane and inhibiting protein synthesis. Some studies report the use of antimicrobial peptides with the potential for action against cancer cells, suggesting a repositioning of antimicrobial peptides to fight back cancer resistance. There is an alteration in the microenvironment, making its net charge negative for the survival and growth of cancer cells. The changes in glycoproteins favor the membrane to have a more negative charge, favoring the interaction between the cells and the peptide, thus making possible the repositioning of these antimicrobial peptides against cancer. Here, we will discuss the mechanism of action, targets and effects of peptides, comparison between microbial and cancer cells, and proteomic changes caused by the interaction of peptides and cells.
Tripartite Split‐GFP for High Throughput Screening of Small Molecules: A Powerful Strategy for Targeting Transient/Labile Interactors like E2‐E3 Ubiquitination Enzymes
Authors: Polge Cécile , Cabantous Stéphanie , Taillandier Daniel 
Published: December 2023

AbstractThe search for inhibitors of the Ubiquitin Proteasome System (UPS) is an expanding area, due to the crucial role of UPS enzymes in several diseases. The complexity of the UPS and the multiple protein‐protein interactions (PPIs) involved, either between UPS proteins themselves or between UPS components and theirs targets, offer an incredibly wide field for the development of chemical compounds for specifically modulating or inhibiting metabolic pathways. However, numerous UPS PPIs are transient/labile, due the processivity of the system (Ubiquitin [Ub] chain elongation, Ub transfer, etc.). Among the different strategies that can be used either for deciphering UPS PPI or for identifying/characterizing small compounds inhibitors, the split‐GFP approach offers several advantages notably for high throughput screening of drugs. Split‐GFP is based on the principle of protein‐fragment complementation assay (PCA). PCA allows addressing PPIs by coupling each protein of interest (POI) to fragments of a reporter protein whose reconstitution is linked to the interaction of the POI. Here, we review the evolution of the split‐GFP approach from bipartite to tripartite Split‐GFP and its recent applicability for screening chemical compounds targeting the UPS.
Balloon atrial septostomy for transposition of the great arteries: Safety and experience with the Z‐5 balloon catheter
Authors: Weeda Jesse A. , Bokenkamp‐Gramann Regina , Straver Bart B. , Rammeloo Lukas , Hahurij Nathan D. , Bertels Robin A. , Haak Monique C. , te Pas Arjan B. , Hazekamp Mark G. , Blom Nico A. , van der Palen Roel L. F. 
Published: December 2023

AbstractBackgroundBalloon atrial septostomy (BAS) is an emergent and essential cardiac intervention to enhance intercirculatory mixing at atrial level in deoxygenated patients diagnosed with transposition of the great arteries (TGA) and restrictive foramen ovale. The recent recall of several BAS catheters and the changes in the European legal framework for medical devices (MDR 2017/745), has led to an overall scarcity of BAS catheters and raised questions about the use, safety, and experience of the remaining NuMED Z‐5 BAS catheter.AimsTo evaluate and describe the practice and safety of the Z‐5 BAS catheter, and to compare it to the performance of other BAS catheters.MethodsA retrospective single‐center cohort encompassing all BAS procedures performed with the Z‐5 BAS catheter in TGA patients between 1999 and 2022.ResultsA total of 182 BAS procedures were performed in 179 TGA‐newborns at Day 1 (IQR 0–5) days after birth, with median weight of 3.4 (IQR 1.2–5.7) kg. The need for BAS was urgent in 90% of patients. The percentage of BAS procedures performed at bedside increased over time from 9.8% (before 2010) to 67% (2017–2022). Major complication rate was 2.2%, consisting of cerebral infarction (1.6%) and hypovolemic shock (0.5%). The rate of minor complications was 9.3%, including temporary periprocedural AV‐block (3.8%), femoral vein thrombosis (2.7%), transient intracardiac thrombus (0.5%), and atrial flutter (2.2%). BAS procedures performed at bedside and in the cardiac catheterization laboratory had similar complication rates.ConclusionsBAS using the Z‐5 BAS catheter is both feasible and safe at bedside and at the cardiac catheterization laboratory with minimal major complications.
A case of blindness caused by Lemierre's syndrome
Authors: Suzuki Tensei , Kojima Mitsuaki , Nakamoto Raira , Kuriyama Keiichi , Tanizawa Shu , Mochida Yuzuru , Asakura Yuri , Shibano Ayaka , Shoko Tomohisa 
Published: December 2023

Key Clinical MessageWe describe a patient who lost her vision because of Lemierre's syndrome. Ophthalmologic complications of Lemierre's syndrome are rare, and very few cases have been reported. Clinicians need to recognize that it is a serious condition that can lead to blindness in some cases.AbstractLemierre's syndrome is a systemic septic embolism resulting from thrombophlebitis of the internal jugular vein. We report a case of blindness caused by Lemierre's syndrome, despite prompt diagnosis and early treatment. A 36‐year‐old woman was transported to our hospital. She presented with fever, facial swelling, and right visual acuity deterioration. Contrast‐enhanced computed tomography revealed a retropharyngeal abscess and right internal jugular vein thrombosis. Blood culture revealed Fusobacterium necrophorum, suggesting Lemierre's syndrome. The patient had septic shock and disseminated intravascular coagulation. We diagnosed her visual impairment as orbital‐apex syndrome due to spread of inflammation. After 6 weeks of antimicrobial drug treatments, her general condition had improved, and the retropharyngeal abscess had disappeared. On Day 49 of her illness, she was transferred to a rehabilitation hospital, but her visual acuity was not restored. Clinicians should be aware that Lemierre's syndrome can, although rarely, cause blindness.
Effect of the Current Density on the Electrodeposition Efficiency of Zinc in Aqueous Zinc‐Ion Batteries
Authors: Tribbia Michele , Glenneberg Jens , La Mantia Fabio , Zampardi Giorgia 
Published: December 2023

AbstractIncreasing the electrodeposition efficiency of metallic zinc from quasi‐neutral aqueous electrolytes is one of the major key requirements for the commercialization of rechargeable aqueous Zn‐ion batteries. Several strategies have been recently reported in the literature. Unfortunately, electrochemical studies on the effect of different current densities on the zinc electrodeposition efficiency usually are not recorded in realistic experimental conditions: e. g. depth of discharges <1–10 %, use of negative electrodes with infinite reservoir of Zn2+, etc. Here, the effect of the current density on the zinc electrodeposition onto optimized bismuth‐indium substrates cycled with 33 % of depth of discharge in a ZnSO4‐containing aqueous solution has been investigated. It was found that low Zn plating/stripping current densities displayed higher electrodeposition efficiencies over 200 Zn electrodeposition/dissolution cycles, more homogeneous distribution of the zinc deposits and lower amounts of inactive zinc passivation products. When higher current densities were applied during the Zn plating/stripping cycles, lower electrodeposition efficiencies and a greater amount of inactive zinc hydroxides and dead zinc were observed on the electrode surface.
A nationwide trend analysis on the usage of endomyocardial biopsy
Authors: Keller Karsten , Göbel Sebastian , Gori Tommaso , Münzel Thomas , Wenzel Philip , Hobohm Lukas 
Published: December 2023

AbstractBackgroundEndomyocardial biopsy (EMB) is a safe procedure performed in diagnostic work‐up of cardiac disease.HypothesisData regarding temporal trends of total numbers, characteristics, in‐hospital outcomes, and complications of patients undergoing EMB are sparse.MethodsThe nationwide German inpatient sample (2005–2019) was used for this analysis. Patient cases of EBM during the 5‐year cycles from 2005 to 2009, 2010 to 2014, and 2015 to 2019 were compared, and temporal trends regarding total numbers and presumable major and minor EMB‐associated complications were investigated.ResultsOverall, 67 745 EMB were performed in Germany 2005–2019. Total number of EMB increased from 3083 in 2005 to 5646 in 2019 (β 0.40 [95% confidence interval [CI] 0.37–0.43], p < .001). Among these EMB, 19 083 (28.2%) were performed during the period 2005–2009, 22 867 (33.7%) 2010–2014, and 25 795 (38.1%) between 2015 and 2019. The proportion of patients aged ≥70 years was highest 2015–2019 (2005–2009: 9.3%; 2010–2014: 13.8%; 2015–2019: 16.1%, p < .001) and the most aggravated comorbidity profile (Charlson Comorbidity Index 2.25 ± 1.93; 2.67 ± 2.14; 3.01 ± 2.29, p < .001) was also detected 2015–2019. Major complications occurred less often in the period 2015–2019 compared to 2005–2009 (odds ratio [OR] 0.921 [95% CI 0.893–0.950], p < .001), whereas minor complications were more frequently observed between 2015 and 2019 (OR 1.067 [95% CI 1.042–1.093], p < .001). While a decrease in major complications was detected irrespective of age, an increase in minor complications was identified only in patients between 30–59 years.ConclusionsAnnual numbers of EMB increased significantly in Germany 2005–2019. Patients who underwent EMB in recent years were older and showed an aggravated comorbidity profile accompanied by fewer major complications, underscoring safety of the procedure.
Cognitive, neuropsychiatric and neurological alterations in mastocytosis: A systematic review
Authors: Sagües‐Sesé Elena , García‐Casares Natalia , Álvarez‐Twose Ivan 
Published: December 2023

AbstractBackgroundMastocytosis manifests with multisystemic symptoms, often involving the nervous system. Numerous cognitive, neuropsychiatric and neurological alterations have been reported in multiple observational studies.MethodsWe performed a qualitative systematic literature review of reported data consulting the electronic databases Medline, Scopus, Web of Science, Cochrane, and BASE until June 2023.ResultsWe selected 24 studies in which the majority showed that a high proportion of mastocytosis patients suffer cognitive, neuropsychiatric and neurological alterations. The most common disorders and estimated ranges of frequency observed in adults were depression (68%–75%), anxiety, high stress or irritability (27%–54%), cognitive impairment (27%–39%, primarily affecting memory skills), and headaches (55%–69%). Attention challenges and learning difficulties were reported in children at a rate of 13%, while neurodevelopmental disorders occurred at rates of 8%–12%. Frequent white abnormalities in mastocytosis patients with concomitant psychocognitive symptoms have been reported although neuroimaging studies have been performed rarely in this population.ConclusionFurther studies with more comprehensive and homogeneous evaluations and neuroimaging and histological analysis should be performed for a better understanding of these manifestations. An earlier detection and proper management of these symptoms could greatly improve the quality of life of these patients.
Smart contract generation for inter‐organizational process collaboration
Authors: Xiong Tianhong , Feng Shangqing , Pan Maolin , Yu Yang 
Published: December 2023

SummaryCurrently, inter‐organizational process collaboration (IOPC) has been widely used in the design and development of distributed systems that support business process execution. Blockchain‐based IOPC can establish trusted data sharing among participants, attracting more and more attention. The core of such study is to translate the graphical model (e.g., BPMN) into program code called smart contract that can be executed in the blockchain environment. In this context, a proper smart contract plays a vital role in the correct implementation of block‐chain‐based IOPC. In fact, the quality of graphical model affects the smart contract generation. Problematic models (e.g., deadlock) will result in incorrect contracts (causing unexpected behaviors). To avoid this undesired implementation, this article explores to generate smart contracts by using the verified formal model as input instead of graphical model. Specifically, we introduce a prototype framework that supports the automatic generation of smart contracts, providing an end‐to‐end solution from modeling, verification, translation to implementation. One of the cores of this framework is to provide a CSP#‐based formalization for the BPMN collaboration model from the perspective of message interaction. This formalization provides precise execution semantics and model verification for graphical models, and a verified formal model for smart contract generation. Another novelty is that it introduces a syntax tree‐based translation algorithm to directly map the formal model into a smart contract. The required formalism, verification, and translation techniques are transparent to users without imposing additional burdens. Finally, a set of experiments shows the effectiveness of the framework.
Privacy‐preserving graph publishing with disentangled variational information bottleneck
Authors: Ma Liya , Li Chen , Sun Siqi , Guo Shu , Wang Lihong , Li Jianxin 
Published: December 2023

SummarySocial networks collect enormous amounts of user personal and behavioral data, which could threaten users' privacy if published or shared directly. Privacy‐preserving graph publishing (PPGP) can make user data available while protecting private information. For this purpose, in PPGP, anonymization methods like perturbation and generalization are commonly used. However, traditional anonymization methods are challenging in balancing high‐level privacy and utility, ineffective at defending against both various link and hybrid inference attacks, as well as vulnerable to graph neural network (GNN)‐based attacks. To solve those problems, we present a novel privacy‐disentangled approach that disentangles private and non‐private information for a better privacy‐utility trade‐off. Moreover, we propose a unified graph deep learning framework for PPGP, denoted privacy‐disentangled variational information bottleneck
(PDVIB). Using low‐dimensional perturbations, the model generates an anonymized graph to defend against various inference attacks, including GNN‐based attacks. Particularly, the model fits various privacy settings by employing adjustable perturbations at the node level. With three real‐world datasets, PDVIB is demonstrated to generate robust anonymous graphs that defend against various privacy inference attacks while maintaining the utility of non‐private information.
The Entropy of van der Waals Fluid
Authors: Lei Yanhua , Wang Xiongliang , Sun Huapeng 
Published: December 2023

AbstractThermodynamic state functions are fundamental quantities in many fields. In this work, the van der Waals (vdW) equation of state and calculation formulas of state functions are derived with statistical thermodynamic method in three‐dimensional (3D) and two‐dimensional (2D) spaces. The heat capacity at constant volume (CV,m) or area (CA,m) is exactly the same as that of ideal gas, but the heat capacity at constant pressure (Cp,m) and other state functions are different from those of ideal gas. The vdW equation of state is a cubic equation, which leads to the fact that the entropy and free energy changes of vdW fluid can be expressed as explicit expressions of volume rather than pressure. Therefore, the adsorbate entropy at constant area can still be theoretically proven to have a linear relationship with the gas‐phase entropy at constant volume. However, the linear correlation between it and gas‐phase entropy at constant pressure is no longer strictly true in theory. In addition, since the vdW equation of state is applicable to both gas and liquid, the linear correlation between adsorbate entropy and liquid‐phase entropy can also be found. At last, the reference state for real gas or fluid at a constant molar volume is suggested.
Isolation of stage‐specific spermatogenic cells by dynamic histone incorporation and removal in spermatogenesis
Authors: Fujiwara Yasuhiro , Hada Masashi , Fukuda Yuko , Koga Chizuko , Inoue Erina , Okada Yuki 
Published: December 2023

AbstractDue to the lack of an efficient in vitro spermatogenesis system, studies on mammalian spermatogenesis require the isolation of specific germ cell populations for further analyses. BSA gradient and elutriation have been used for several decades to purify testicular germ cells; more recently, flow cytometric cell sorting has become popular. Although each method has its advantages and disadvantages and is used depending on the purpose of the experiment, reliance on flow cytometric cell sorting is expected to be more prevalent because fewer cells can be managed. However, the currently used flow cytometric cell sorting method for testicular germ cells relies on karyotypic differences via DNA staining. Thus, it remains challenging to separate post‐meiotic haploid cells (spermatids) according to their differentiation stage despite significant variations in morphology and chromatin state. In this study, we developed a method for finely separating testicular germ cells using VC mice carrying fluorescently tagged histones. This method enables the separation of spermatogonia, spermatocytes, and spermatids based on the intensity of histone fluorescence and cell size. Combined with a DNA staining dye, this method separates spermatids after elongation according to each spermiogenic stage. Although the necessity for a specific transgenic mouse line is less versatile, this method is expected to be helpful for the isolation of testicular germ cell populations because it is highly reproducible and independent of complex cell sorter settings and staining conditions.