bluuebunny/crossref_metadata_2025_split huggingface dataset:
The role of inflammatory immunomodulators in the development of schizophrenia
Authors: Аршинова Е.С. , Карпова Н.С. , Сандомирский К.А. , Нурбеков М.К. , Архипов А.Ю. 
Published: January 2024

Шизофрения является одним из наиболее распространенных многофакторных психических заболеваний. Среди наиболее важных факторов риска развития шизофрении, таких как генетическая предрасположенность, эпигенетические изменения, стресс, внутриутробные, родовые и послеродовые осложнения, важную роль играет нейровоспаление и повышенный синтез провоспалительных цитокинов. Также одним из потенциальных биомаркёров развития шизофрении является рилин – гликопротеин, участвующий в нейротрансмиссии и синаптической пластичности. Стоит отметить, что патогенетические механизмы, лежащие в основе шизофрении, на данный момент точно не установлены, однако изучение связей между экспрессией гена рилина, уровнями провоспалительных цитокинов, а также позитивной и негативной симптоматикой у пациентов с шизофренией может быть потенциально информативным для понимания механизмов развития шизофрении.
Schizophrenia is one of the most common multifactorial mental illnesses. Among the most important risk factors for the development of schizophrenia, such as genetic predisposition, epigenetic changes, stress, intrauterine, birth and postpartum complications, neuroinflammation and increased synthesis of pro-inflammatory cytokines play an important role. Also, one of the potential biomarkers for the development of schizophrenia is reelin, a glycoprotein involved in neurotransmission and synaptic plasticity. It should be noted that the pathogenetic mechanisms underlying schizophrenia have not yet been clearly established, however, the study of relationships between reelin gene expression, levels of pro-inflammatory cytokines, as well as positive and negative symptoms in patients with schizophrenia can be potentially informative for understanding the mechanisms of development of schizophrenia.
Determination of the regulatory potential of polymorphisms associated with preeclampsia
Authors: Карпова Н.С. , Дмитренко О.П. , Нурбеков М.К. 
Published: January 2024

Целью исследования было выявление полиморфизмов с наибольшим регуляторным потенциалом, которые могут стать перспективными маркерами раннего прогноза развития преэклампсии. Материалы и методы. Для выбора полиморфизмов с наибольшим регуляторным потенциалом использовались биоинформатические базы данных: GWAS-catalog, dbSNP, RegulomDB, UCSC. Результаты. Мы оценили регуляторный потенциал 36 полиморфизмов, ассоциированных с преэклампсией, и выявили 7 наиболее перспективных полиморфизмов для дальнейшего изучения (rs1918975, rs1458038, rs10774624, rs7318880, rs1421085, rs259983 и rs4769612).
The aim of the study was to identify polymorphisms with the highest regulatory potential, which can become promising early predictors of preeclampsia. Materials and methods. To select polymorphisms with the highest regulatory potential, bioinformatic databases were used: GWAS-catalog, dbSNP, RegulomDB, UCSC. Results. We assessed the regulatory potential of 36 polymorphisms associated with preeclampsia and identified the 7 most promising polymorphisms for further study (rs1918975, rs1458038, rs10774624, rs7318880, rs1421085, rs259983 and rs4769612).
Logistic Model for Predicting Coliform Growth in Wastewater Effluent From the Chambo River (Ecuador)
Authors: Béjar-Suárez Jaime Giovanny , Muyulema-Allaica Juan Carlos , Béjar Cáceres David Geovanny , Cáceres-Mena Mayra Elizabeth , Mendoza-Trujillo Benito Guillermo , Mendoza-Trujillo Benito Guillermo , Guananga-Diaz Nelly Ivonne 
Published: January 2024

Purpose: The objective of this work is to apply a predictive model of bacterial growth to determine the concentration of total coliforms, under controlled laboratory conditions, in wastewater from the city of Riobamba that flows into the Chambo River (Ecuador).

Theoretical Framework: Wastewater pollution is a global problem that affects water quality and public health. Population growth has a drastic impact on the contamination of water bodies, particularly in Ecuador, since most of the effluents are not adequately treated, which becomes a public health and environmental problem. For this reason, over the years, total and fecal coliforms have been used as indicators of water quality.

Design/Methodology/Approach: The study used a mathematical modeling approach of a logistic and deterministic type, and calculated through an executable command designed in the integrated development environment (IDE) with the Visual C# programming language (logic) and the XAML design language (interface).

Findings: The results achieved are 1) the theoretical construction of a mathematical model (logistic model) starting from a differential equation and the taking of three experimental measurements, 2) the computer construction of the bacterial growth model and 3) it has been demonstrated that there is agreement between the values obtained from the model of total coliform growth and the experimental results with a margin of error of less than 1%.

Research, Practical & Social Implications: This information can be used by stakeholders to determine actions that could improve current conditions.

Originality/Value: The result of this study emphasizes that the model proposed can reproduce the growth of coliforms up to a maximum growth point, it is necessary to continue with the development of the same in the stationary phase of bacterial growth and then in the decay phase.
Hubungan Dinamika Kelompok dengan Tingkat Partisipasi Anggota Kelompok Wanita Tani dalam Program Kawasan Rumah Pangan Lestari (KRPL) di Kecamatan Ampel, Kabupaten Boyolali
Authors: Siburian Sationa Carmelita , Padmaningrum Dwiningtyas , Suwarto Suwarto 
Published: January 2024

Kawasan Rumah Pangan Lestari (KRPL) is a government program for the community in terms of utilizing local resource-based home yards to ensure the sustainable provision of quality and diverse household food. The KRPL program is run by a group of farm women whose implementation requires the participation of farm women in carrying out group activities. Farmer women group members have experienced various ups and downs in group dynamics since its inception. This study aims to determine the dynamics of farm women groups in the KRPL program, determine the level of participation of farm women group members in the KRPL program, and examine the relationship between group dynamics and the level of participation of farm women group members in the KRPL program. Methods of sampling were proportional stratified random sampling with a total of 62 respondents. Data were analyzed using interval width test and Rank Spearman correlation test with IBM SPSS Statistics 25 program. The results showed that there was a significant relationship between group dynamics and the level of participation of farm women group members in the KRPL program including group structure, task function, group atmosphere, group pressure, and hidden agenda.
REVIEW: POTENSI BOREH USADA BALI BERBASIS KEARIFAN LOKAL DENGAN BAHAN UTAMA MELATI PUTIH SEBAGAI ANTIBAKTERI PROPIONIBACTERIUM ACNES
Authors: Giri Gede Sugiartha , Paramita Ni Luh Putu Vidya 
Published: January 2024

Boreh Usada Bali merupakan sarana pengobatan masyarakat Hindu Bali terbuat dari kombinasi tumbuh-tumbuhan yang memiliki khasiat obat. Berdasarkan Usada Taru Pramana tanaman melati putih (Jasminum sambac) memiliki potensi untuk mengurangi jerawat. Boreh Usada Bali dibuat dengan bahan utama khasiat daun melati putih dikombinasikan dengan bahan pendukung khasiat seperti beras, kulit batang kayu manis, kayu cendana, rimpang lempuyang, rimpang kunyit, buah pala, dan garam. Review dilakukan terhadap sediaan boreh dengan komposisi bahan melati putih dan bahan alam lainnya sebagai pendukung khasiat antibakteri terhadap Propionibacterium acnes. Penyusunan artikel ini menggunakan metode studi literatur yang tergolong dalam penelitian deskriptif kualitatif secara sistematis. Potensi boreh Usada Bali melati putih didukung oleh beberapa penelitian tentang antibakteri dari komponen di dalam boreh. Hal ini karena, melati putih dilaporkan memiliki senyawa tanin dan flavonoid dan untuk bahan pendukung khasiat boreh lainnya mengandung senyawa aktif utama seperti kulit batang kayu manis (sinamaldehid dan eugenol), kayu cendana (α-santalol, β-santalol, dan epi-β-santalen), lempuyang (zerumbon), kunyit (kurkuminoid), dan pala (monoterpen) dengan mekanisme masing-masing yang berperan sebagai antibakteri terhadap bakteri Propionibacterium acnes. Sediaan boreh dengan bahan utama khasiat melati putih dan bahan pendukung khasiat boreh (kulit batang kayu manis, kayu cendana, rimpang lempuyang, rimpang kunyit, buah pala) berpotensi sebagai antibakteri terhadap Propionibacterium acnes. Kata kunci: Antibakteri, boreh, jasminum sambac, propionibacterium acnes, usada bali.
The Impact of Technological Innovation on Business Model Innovation and Start-up Performance
Authors: Dong Vu Van , Ghi Tran Nha , Thu Nguyen Quang 
Published: January 2024

The success rate of start-up firms in Vietnam could be low 20.8%. To address this issue, improving start-up performance through technological innovation and business model innovation is crucial. The relationship between technological innovation, business model innovation (BMI), and start-up performance has yet to be widely examined in developing countries like Vietnam. This study employs Partial Least Squares Structural Equation Modeling (PLS-SEM) to analyze data from 425 entrepreneurs. The findings reveal that technological innovation has a positive impact on business model innovation and start-up performance; business model innovation also has a positive impact on start-up performance; and the study identifies the partial mediating role of business model innovation between technological innovation and start-up performance. The results have practical implications for entrepreneurs, start-up founders, and policymakers. It emphasizes investing in technological and business model innovations to improve start-up performance. Lastly, the study highlights some limitations and suggests future research directions. Doi: 10.28991/HEF-2023-04-03-01 Full Text: PDF
Exercise Motivation among Fitness Center Members: A Combined Qualitative and Q-Sorting Approach
Authors: Nam Truong Thanh , Suwanbamrung Charuai , Dadras Omid , Hou Xiang-Yu , Phu Doan Hoang , Tin Pham Trung , Quang Huynh Khai , Thuy Thai Thi Ngoc , Ageru Temesgen A. , Aekwarankoon Saifon , Isaramalai Sang-arun , Le Cua Ngoc 
Published: January 2024

This study aimed to explore the components of Exercise Maintenance Motivation (EMM) and identify its consensus and distinguishing aspects among members of fitness centers (FCs) in Vietnam. The study incorporated both qualitative and Q-sorting methodologies across two stages. The first stage involved conducting ten in-depth and four focus-group interviews with 39 members of six different FCs in Vietnam, resulting in the generation of 40 EMM statements. In the second stage, these statements were subjected to Q-sorting by 39 participants. The KADE application for the Q method was used for data analysis, and Principal Component Analysis was employed to determine the optimal number of factors. The analysis yielded four factors, encompassing 34 statements and accounting for 86% of the variance in EMM components among participants. These components, labeled “F1. Exercise achievements”, “F2. Exercise environments”, “F3. Exercise enjoyment”, and “F4. Workout-aholic”, achieved consensus among 17 (37%), 14 (30%), 5 (12%), and 3 (7%) participants, respectively. The leading motivational expressions were “get to be healthier”, “a better-looking appearance”, and “get a fit body appearance”. These were followed by FC-based supportive exercise conditions, positive feelings, and exercise addiction. There were five consensus statements that spanned all four factors. The numbers of distinguishing statements varied across factors, with F1, F3, and F4 each contributing 11 (28.2%) and F2 contributing 15 (38.5%). This study contributed to the four central drivers of EMM. To facilitate the development of a comprehensive EMM scale, future research should incorporate larger samples, allowing for a dissection of motivational paradigms. Doi: 10.28991/HEF-2023-04-03-07 Full Text: PDF
Kesadaran dan Loyalitas Masyarakat Terhadap Perjanjian Perkawinan
Authors: Anindita Shifa , Maryandi Yandi 
Published: January 2024

Abstract Indonesia has detailed written rules regarding marriage. This can be seen from the Marriage Law No. 1 of 1974 in conjunction with Law No. 16 of 2019. In the Law in question, one of them is discussing matters relating to marriage agreements. The problem points used are how the views of the people of the Gumuruh Village area regarding the marriage agreement. How is the awareness and loyalty of the Gumuruh Village community towards the marriage agreement. With the aim to see how the views and levels of awareness, community loyalty to the marriage agreement and analyze the factors. The method used in this study is a mixed method, namely qualitative and quantitative methods. Therefore, the theory used in this study is the sociology of law in awareness and loyalty to the law. The results of the existing research show that the people of Gumuruh Village view the marriage agreement as a legal act which is indeed important for some people who really feel the need and in this modern era the marriage agreement can develop well. Based on calculations to see the level of awareness and loyalty seen from the final result of the calculation based on the community's answers. that the value of awareness is 0.071. loyalty of 0.836 and 0.034 interest in the marriage agreement. The views that the community gives are factored in by literacy, socialization and the wishes of the community itself.
Abstrak Indonesia memiliki aturan tertulis tentang perkawinan secara rinci, hal ini dapat dilihat dari Undang Undang Perkawinan No,1 tahun 1974 jo Undang Undang No.16 tahun 2019. Dalam Undang Undang yang dimaksud, salah satunya ialah membahas berkaitan dengan perjanjian perkawinan. Poin masalah yang digunakan ialah Bagaimana pandangan masyarakat wilayah Kelurahan Gumuruh terhadap perjanjian perkawinan, Bagaimana kesadaran dan loyalitas masyarakat Kelurahan Gumuruh terhadap perjanjian perkawinan. Dengan tujuan untuk melihat bagaimana pandangan dan tingkatan kesadaran, loyalitas masyarakat terhadap perjanjian perkawinan serta menganalisis faktornya. Metode yang digunakan dalam penelitian ini merupakan mix method yakni metode secara kualitatif dan kuantitatif. Oleh karena itu, teori yang dipakai dalam penelitian ini ialah sosiologi hukum dalam kesadaran dan loyalitas terhadap hukum. Hasil dari penelitian yang ada menunjukan bahwa masyarakat Kelurahan Gumuruh memandang perjanjian perkawinan sebuah perbuatan hukum yang memang penting untuk sebagian masyarakat yang memang merasa membutuhkan dan di era modern ini perjanjian perkawinan dapat berkembang baik. Berdasarkan perhitungan untuk melihat tingkatan kesadaran dan loyalitas dilihat dari hasil akhir perhitungan berdasarkan jawaban masyarakat, bahwa nilai dari kesadaran sebesar 0,071, loyalitas sebesar 0,836 dan minat 0,034 terhadap perjanjian perkawinan. Pandangan yang masyarakat berikan difaktori oleh literasi, sosialisasi dan keinginan dari masyarakat itu sendiri.
A Recombinant DNA Technique in The Genetic Engineering of Insulin from Bacteria
Authors: Rahman Khaidir Yusuf , Sanely  , Defa Pratama  , Ziske Maritska  
Published: January 2024

Abstract. Human Growth and human insulin were the first proteins to be produced on an industrial scale. Methods: The research method used in this study was a clinical literature review on recombinant DNA techniques from insulin in bacteria from the review literature taken from Pubmed and SCopus, for further search and analysis with other existing research. Recombinant DNA technology comprises altering genetic material outside an organism to obtain enhanced and desired characteristics in living organisms or as their products. Two biosynthetic insulin analogs have sufficiently long duration of action for use as once-daily basal insulins. Some biosimilars have been developed to human insulins as produced by Lilly and NovoNordisk, but their use is more restricted given the problems encountered by the use of human insulin, see Dolinar et al for a recent review of the field. Several companies have developed or are developing depot preparations that can be administered one a week instead of once a day. Recombinant DNA technology is an important development in science that has made the human life much easier. The clinical effect of Growth hormone therapy in children can be best measured on an annual basis and compared with predicted adult height whereas failure to lower blood sugar can be seen immediately in insulin or insulin analogue therapy.
Abstrak. Pertumbuhan Manusia dan insulin manusia adalah protein pertama yang diproduksi dalam skala industri. Metode penelitian yang digunakan dalam penelitian ini adalah tinjauan literatur klinis mengenai teknik DNA rekombinan dari insulin pada bakteri dari tinjauan literatur yang diambil dari Pubmed dan SCopus, untuk selanjutnya dicari dan dianalisis dengan penelitian lain yang sudah ada. Teknologi DNA rekombinan terdiri dari pengubahan materi genetik di luar suatu organisme untuk memperoleh karakteristik yang ditingkatkan dan diinginkan pada organisme hidup atau sebagai produknya. Dua analog insulin biosintetik mempunyai durasi kerja yang cukup lama untuk digunakan sebagai insulin basal sekali sehari. Beberapa biosimilar telah dikembangkan untuk insulin manusia seperti yang diproduksi oleh Lilly dan NovoNordisk, namun penggunaannya lebih dibatasi mengingat permasalahan yang dihadapi dalam penggunaan insulin manusia, lihat Dolinar dkk untuk tinjauan terbaru di lapangan. Beberapa perusahaan telah mengembangkan atau sedang mengembangkan persiapan depot yang dapat diberikan satu kali dalam seminggu, bukan sekali sehari. Teknologi DNA rekombinan merupakan perkembangan penting dalam ilmu pengetahuan yang telah membuat hidup manusia lebih mudah. Efek klinis terapi hormon pertumbuhan pada anak-anak paling baik diukur setiap tahun dan dibandingkan dengan prediksi tinggi badan orang dewasa, sedangkan kegagalan menurunkan gula darah dapat langsung terlihat pada terapi insulin atau analog insulin.
Infeksi Helicobacter pylori pada Penderita Gastritis menjadi Faktor Risiko Anemia Defisiensi Besi
Authors: Aditya Pradipta Lantik  , Sadeli  , Purnomo  
Published: January 2024

Abstract. The prevalence of H.pylori in Indonesia reaches 40%. H.pylori infection mostly associated with chronic gastritis and can lead to iron deficiency anemia, because H.pylori can interfere with iron metabolism and can cause bleeding in the stomach. The purpose of this study was to analyze whether there was a relationship between H.pylori infection and the incidence of iron deficiency anemia in patients with gastritis. The research uses a scoping review study to identify, analyze, and evaluate scientific papers through Pubmed, SpringerLink, and ScienceDirect data sources that fulfil the inclusion, exclusion criteria and use the JBI Critical Apprasia Checklist summarized in the PRISMA diagram. 6,514 articles were generated from the 4 data sources, 4 articles fulfilled the inclusion, exclusion and eligibility criteria. The results of the 3 articles stated that there was a relationship between H.pylori and the incidence of iron deficiency anemia in bleeding gastritis patients, while 1 article stated that there was no significant difference between H.pylori and the incidence of iron deficiency anemia in gastritis patients. The conclusion of this study that there was a relationship between H.pylori and the incidence of iron deficiency anemia in patients with gastritis who had experienced bleeding.
Abstrak. Prevalensi infeksi H.pylori di Indonesia mencapai angka 40%. Infeksi H.pylori sebagian besar berhubungan dengan kejadian gastritis kronis dan mampu mengakibatkan terjadinya anemia defisiensi besi, karena H.pylori dapat mengganggu metabolisme besi dan dapat mengakibatkan terjadinya perdarahan pada lambung. Tujuan penelitian ini adalah untuk menganalisis apakah terdapat hubungan antara infeksi H.pylori dengan kejadian anemia defisiensi besi pada pasien gastritis. Penelitian menggunakan studi scoping review untuk mengidentifikasi, menganalisis, dan mengevaluasi tulisan ilmiah melalui sumber data Pubmed, SpringerLink, dan ScienceDirect yang memenuhi kriteria inklusi, eksklusi dan kelayakan menggunakan JBI Critical Apprasial Checklist dirangkum dalam diagram PRISMA. Dihasilkan 6.514 artikel dari 4 sumber data, 4 artikel yang memenuhi kriteria inklusi, eksklusi dan kelayakan. Hasil dari 3 artikel menyatakan terdapat hubungan antara infeksi H.pylori dengan kejadian anemia defisiensi besi pada pasien gastritis yang mengalami perdarahan, sedangkan 1 artikel menyatakan tidak ditemukan perbedaan yang signifikan antara infeksi H.pylori dengan kejadian anemia defisiensi besi pada pasien gastritis. Simpulan dari penelitian ini didapatkan adanya hubungan antara infeksi H.pylori dengan kejadian anemia defisiensi besi pada pasien gastritis yang mengalami perdarahan.
Sanitasi Lingkungan Berpengaruh terhadap Kejadian Skabies pada Santri Laki-laki di Ponpes
Authors: Ahmad Roisul Umam  , Nanan Sekarwana  , Mia Yasmina Andarini  
Published: January 2024

Abstract. Scabies is a disease caused by the parasite Sarcoptes scabiei var hominis. Scabies is transmitted through direct or indirect contact, according to the World Health Organization (WHO). Currently, scabies is still a problem in developing countries, with an estimated worldwide prevalence of around 200 million population; according to data from the Ministry of Health (Indonesian Ministry of Health), scabies is a disease of the skin that is often treated in health centers. This study aimed to determine the relationship between environmental sanitation and the incidence of scabies in male students at the Choirul Huda Islamic Boarding School, Rajeg District, Tangerang Regency. This study used a cross-sectional approach, involving 147 respondents who were taken by random sampling to obtain a minimum of 82 samples using a questionnaire at the Choirul Huda Islamic Boarding School from February to November 2022. The analysis using Chi-Square showed a significant relationship between sanitation (p -value=0.019) and the incidence of scabies in male students at the Choirul Huda Islamic Boarding School, Tangerang Regency. This study's results indicate a relationship between sanitation and the incidence of scabies in male students at the Choirul Huda Islamic boarding school, Tangerang Regency.
Abstrak. Skabies merupakan sebuah penyakit yang disebabkan karena parasit Sarcoptes scabiei var hominis.Penyakit skabies ini menular melalui kontak langsung maupun tidak langsung, menurut World Health Organization ( WHO) saat ini skabies masih menjadi permasalahan di negara berkembang dengan prevalensi secara mendunia diperkiraan menjangkit kurang lebih 200 juta penduduk, menurut data KEMENKES (Kementrian Kesehatan Indonesia) skabies merupakan sebuah penyakit pada kulit yang kerap di tangani di puskesmas. Tujuan dari penelitian ini adalah untuk mengetahui hubungan sanitasi lingkungan terhadap kejadian skabies pada santri laki-laki di Pondok Pesantren Choirul Huda Kecamatan Rajeg Kabupaten Tangerang. Penelitian ini menggunakan pendekatan crossectional, dengan mengikutsertakan 147 responden yang diambil dengan metode random sampling untuk mendapatkan 82 sampel minimum menggunakan kuesioner di Pondok Pesantren Choirul Huda pada periode Februari – November 2022. Hasil analisis menggunakan Chi-Square menunjukan bahwa terdapat hubungan bermakna antara sanitasi (p-value=0,019) dengan kejadian skabies pada santri laki-laki di Pondok Pesantren Choirul Huda Kabupaten Tangerang. Hasil penelitian ini menunjukan adanya hubungan antara sanitasi dengan kejadian skabies pada santri laki-laki di pondok pesantren Choirul Huda Kabupaten Tangerang.