bluuebunny/crossref_metadata_2025_split huggingface dataset:
A Case of Malignant Melanoma: Disease Progression Correlated with Serum Levels of 5‐S‐Cysteinyldopa (5‐S‐CD) and Intercellular Adhesion Molecule‐1 (ICAM‐1)
Authors: Ye Zushou , Kageshita Toshiro , Ishihara Tsuyoshi , Ito Shosuke , Ono Tomomichi 
Published: October 2023

AbstractA 36‐year‐old Japanese female, in whom malignant melanoma was detected from symptoms of brain metastasis, died 7 months later.The serum levels of 5‐S‐Cysteinyldopa (5‐S‐CD) and intercellular adhesion molecule‐1 (ICAM‐1) correlated with the disease progression. These values may be useful markers of disease progression for malignant melanoma, because the material is easily, frequently, and non‐invasively obtained at regular intervals.
A Case of Bullous Pemphigoid with Antibodies against Intercellular 130 KD Antigen
Authors: Takahashi Hidetoshi , Wada Takashi , Matsuo Shinobu , Iwatsuki Keishi , Iizuka Hajime 
Published: October 2023

AbstractPemphigus and bullous pemphigoid are two typical autoimmune bullous diseases that involve circulating autoantibodies directed against the epidermal cell surface and the epidermal basement membrane zone, respectively. The coexistence of pemphigus and bullous pemphigoid is rare. We describe a case of a 79‐year‐old man who had tense bullae and erythematous, erosive lesions on his trunk and four extremities. Histopathology revealed subepidermal blister formation without any evidence of intraepidermal acantholytic changes. Direct immunofluorescence study demonstrated deposition of IgG on the epidermal intercellular spaces, as well as along the basement membrane zone; C3 was detected only on the latter. Indirect immunofluorescence study using monkey esophagus as a substrate demonstrated the presence of circulating antibodies against both junctional and intercellular antigens. In order to analyze the precise nature of this patient's antibodies, indirect immunofluorescence study using cultured human keratinocytes and immunoblot analyses were performed. Pemphigus vulgaris sera showed smooth and uniform staining on intercellular spaces. The patient's serum showed a granular and uneven staining pattern. Immunoblot analysis showed that the patient's serum reacted with the typical 230 kd (bullous pemphigoid) antigen and 130 kd antigen, which is close to the pemphigus vulgaris antigen.
Comparative ontogeny and phylogenetic relationships of eight lizardfish species (Synodontidae) from the Northwest Pacific, with a focus on Trachinocephalus monophyly
Authors: Choi Si‐Won , Yu Hyo‐Jae , Kim Jin‐Koo 
Published: October 2023

AbstractLizardfish (Aulopiforms: Synodontidae), distributed broadly in temperate to tropical waters, are represented globally by 83 species across four genera, with 10 species in Korea. Despite these numbers, few studies have been conducted on the early life history of lizardfishes compared to their adult counterparts. Thus, we conducted molecular identification of 123 Synodontidae larvae collected from the Northwest Pacific (Korea Strait, Yellow Sea, East China Sea, and East Sea) between June 2017 and July 2021, using mitochondrial DNA COI and 16S rRNA sequences. Significant morphological differences were observed in the larvae and juvenile, including variation in melanophore, count, morphometric characteristics, and body shape. The morphological traits of eight species (Harpadon nehereus, Saurida macrolepis, Saurida wanieso, Saurida sp., Synodus hoshinonis, Synodus kaianus, Synodus macrops, and Trachinocephalus trachinus) served as vital data for interpreting the phylogenetic relationships within the Northwest Pacific Synodontidae. Ultimately, the identification key revealed by this study will enable accurate identification of Synodontid larvae and juveniles, and further facilitate our understanding of the phylogenetic relationships within this family.
Role of TRAF6 from obscure puffer (Takifugu obscurus) in immune response against Edwardsiella tarda infection
Authors: Shi Yan , Liang Xiaying , Hu Sufei , Wang MengMeng , Wang Yifan , Zhao Zhe 
Published: October 2023

AbstractTumor necrosis factor receptor‐associated factor 6 (TRAF6) is a vital molecule of inflammatory signaling pathways in innate immune response against pathogens. To elucidate its role in defense against Edwardsiella tarda infection in teleost fish, TRAF6 homologue was identified from obscure puffer (Takifugu obscurus) and functionally analyzed in this study. The obscure puffer TRAF6 (ToTRAF6) is a protein of 565 amino acids containing conserved RING domain, zinc finger‐TRAF and MATH_TRAF6 domain. ToTRAF6 mRNA distributed in various healthy tissues of obscure puffer and was upregulated in the immune related tissues after E. tarda infection. ToTRAF6 protein was localized in the cytoplasm and aggregate as dots around the nuclei in FHM cells. The overexpression of ToTRAF6 in FHM cells decreased the quantity of E. tarda and induced the significant upregulation of downstream MAPK signaling pathway genes. These data suggest that ToTRAF6 is a key molecule of MAPK signaling pathway in defense against E. tarda infection.
Application of dual‐frequency ultrasound for reduction of perilesional edema and ecchymosis after rhinoseptoplasty
Authors: Ahn Tae‐Hwan , Lee Je Seong , Kim Sung‐Yeon , Lee Sang‐Bong , Kim Wanjae , Kruglik Ilja , Yi Kyu‐Ho 
Published: October 2023

AbstractObjectivesBiological aspect and clinical research demonstrated that dual‐frequency ultrasound (local dynamic micro‐massage, LDM) waves of very high frequency can significantly modify cellular signaling providing anti‐inflammatory and anti‐fibrotic effects. During the recent past, these waves were successfully applied for the treatment of various inflammatory skin conditions, hypertrophic scars, and chronical wounds. Since the main complications after rhinoseptoplasty are caused by excessive inflammatory reactions and development of fibrosis along nasal implants which can lead to a revision rhinoseptoplasty, in this retrospective multicenter blinded study we have evaluated the efficacy of LDM ultrasound for the treatment of the postoperative perilesional ecchymosis and edema in patients after rhinoseptoplasty.MethodsTwenty‐four patients received daily LDM treatment (study group) for 5 days starting from the first day postoperative, whereas 24 patients (control group) were treated with conventional ice packs. Dynamic reduction of the postoperative perilesional ecchymosis and edema was followed up, and the total duration of these side effects was determined within specific paranasal anatomical areas.ResultsPost‐rhinoseptoplasty ecchymosis and edema were observed in the areas of anterior cheek, lower eyelids, and upper eyelids. Duration of the postoperative perilesional edema was significantly reduced in the group treated with LDM (1.9 ± 0.9 days) compared with control group (4.5 ± 2.1 days). Duration of the ecchymosis was also significantly reduced in LDM group (2.8 ± 1.4 days) compared with controls (7.4 ± 2.8 days). Postoperative patient satisfaction in LDM‐treated and control groups was 3.1 ± 1.3 and 1.5 ± 0.7, respectively, demonstrating significantly higher satisfaction in LDM‐treated group.ConclusionsThis study proved that the post‐rhinoseptoplasty group treated with LDM ultrasound showed a significantly shorter duration of the postsurgical perilesional ecchymosis and edema, with no substantial adverse effects other than those observed in the control group. It can be suggested that ultrasound treatment can serve as an alternative option for the noninvasive management of postoperative perilesional ecchymosis and edema.
Effectiveness of dyadic interventions among cancer dyads: An overview of systematic reviews and meta‐analyses
Authors: Sun Qian , Wang Kunyuan , Chen Yingliang , Peng Xiuhua , Jiang Xiaohan , Peng Junsheng 
Published: October 2023

AbstractAims and ObjectiveTo summarize evidence from systematic reviews (SRs)/meta‐analyses (MAs) regarding the impact of dyadic interventions delivered to both members of a cancer dyad, including a cancer patient and caregiver (e.g. family caregiver, intimate partner).DesignThis overview of SRs was conducted in accordance with the preferred reporting items for overviews of reviews statement.MethodsA comprehensive search of multiple databases, including PubMed, Cochrane Library, Embase, CINAHL, Web of Science, China National Knowledge Infrastructure and Wan Fang. The methodological and reporting quality of SRs and MAs was assessed using the Assessing the Methodological Quality of Systematic Reviews 2. The quality of the included SRs/MAs was evaluated using the Grades of Recommendations, Assessment, Development and Evaluation approach.ResultsEighteen SRs/MAs undertook quantitative synthesis to assess the impact of dyadic interventions on cancer dyads. Both the credibility of the SRs/MAs and the evidence quality of the outcome measures were below satisfactory standards. Prior SRs/MAs revealed several limitations such as lack of pre‐published protocols or research objectives, failure to report excluded studies and insufficient details on funding sources for individual studies.ConclusionsDyadic interventions may prove advantageous for the physical health and dyadic adjustment of cancer dyads. Nevertheless, the reported results of dyadic interventions on the psychological health of patient–caregiver dyads affected by cancer are inconsistent. Thus, rigorous and comprehensive studies are requisite to establish reliable evidence for conclusive determinations.Relevance to Clinical PracticeThe findings of this overview can guide healthcare practitioners when considering the use of dyadic interventions for cancer dyads. Moreover, these findings have the potential to enhance the integration of these approaches into clinical practice.Patient or Public ContributionOur paper presents an overview of systematic reviews, and therefore, such specific details may not be relevant to our study.
Treatment of recurrent hunting‐associated respiratory distress episodes in 2 dogs
Authors: Dumont Renaud , Touzet Chloé , Gomes Eymeric , Le Boedec Kevin 
Published: October 2023

AbstractNoncardiogenic pulmonary edema (NCPE) in hunting dogs is an uncommon and poorly described condition for which no preventive treatment is available. Two dogs were presented for recurrent respiratory distress strictly associated with hunting activities. Diagnosis was based on bilateral, symmetrical, interstitial‐to‐alveolar pattern in the caudodorsal lung fields on thoracic radiographs, exclusion of other causes, and spontaneous clinical and radiographic improvement. Considering that the pathogenesis of exercise‐induced NCPE likely involves α‐ and β‐adrenergic overstimulation, treatment with sympathetic blockers was used in both dogs. The first dog no longer showed respiratory signs during hunting activities. However, treatment failed to prevent respiratory distress in the other dog. Based on the large number of red blood cells in the bronchoalveolar lavage fluid of the second dog, exercise‐induced pulmonary hemorrhage was suspected, as described in racing horses. The loop diuretic furosemide successfully prevented further hunting‐associated respiratory distress episodes in this dog.
Revenue sharing, fiscal incentives, and economic growth: Evidence from China
Authors: Chen Yixin , Lyu Bingyang , Ma Guangrong 
Published: October 2023

AbstractThis study revisited the impact of fiscal decentralization on China's economic growth, focusing on the role of the revenue‐sharing system in providing local fiscal incentives. Using city‐level data from 2003 to 2016, we construct the revenue retention rate at the sub‐provincial level to test the impacts of fiscal incentives on economic growth. The results show that the sub‐provincial revenue retention rate is significantly and positively associated with the local economic growth rate. Further, we find that a higher revenue retention rate encourages sub‐provincial governments to spend more on infrastructure, borrow more debt, distort land price, and relax environmental regulatory standards. Our findings indicate that the positive economic effect of fiscal decentralization is accompanied by a social cost and increased financial risk.
The Science of Microteaching and Learning: An Exploratory Study
Authors: Howard‐Jones Paul , Scott Annabel , Gordillo Carolina 
Published: October 2023

ABSTRACTThe teaching‐learning relationship in online microteaching was explored using mixed methods. Adults (N = 40) alternated roles of “teacher” and “student” during a 15‐min language learning session. Video analysis using a context‐specific framework based on the science of learning revealed diversity in teaching approaches. Multiple regression revealed teaching behaviors that had been reasoned to build and consolidate knowledge contributed to learning but behaviors that had been reasoned to engage the student appeared to have a negative impact. No relationship was found between learning and participants' teaching experience (which was chiefly teaching second languages to children). Results demonstrate the complexity of teaching and its irreducibility to a set of prescriptive behaviors. They also suggest that a process‐based context‐specific analysis of online microteaching can provide a “bridging” tool for researchers and practitioners to address fundamental questions about teaching and so develop a “science of teaching”.
Pandemic impact and adaptation to telehealth in chronic pain treatment providers across two COVID‐19 pandemic years
Authors: Vowles Kevin E. , Knaggs Roger D. , Palomares Angela C. 
Published: October 2023

AbstractObjectivesThe COVID‐19 pandemic has had substantial impacts for both people using pain services and healthcare professionals delivering them. While the effects on service users have been studied, less is known about the effects for service providers. This study aimed to assess the impact of the pandemic on providers and the evolving role of telemedicine in treatment.Design & MethodsAn electronic survey was distributed to the professional membership of the European Pain Federation (EFIC). The survey evaluated impact and adjustment to the COVID‐19 pandemic separately across two pandemic years (March 2020–February 2021 and March 2021 to February 2022) and assessed worry about COVID‐19, disruption and adjustment of pain services, and use of telehealth services. The change between the first and second pandemic years and the degree to which telehealth services were adopted was evaluated.ResultsFrom 149 respondents, 131 (88%) participants provided sufficient data to be included in the analysis. Both providers worry about the pandemic and service disruption decreased significantly from the first to the second year of the pandemic. Prior to the pandemic, only 30% of providers offered telehealth appointments but this increased to 64% and 83%, respectively, in the first and second years of the pandemic.ConclusionsAlthough provider worry and disruption to delivery of pain services decreased during the second year of COVID‐19 pandemic, waiting times for appointments continued to lengthen. The pandemic has hastened the adoption of telemedicine in pain services and plans to continue telehealth services seem common.
Heatwaves do not limit recovery following defoliation but alter leaf drought tolerance traits
Authors: O'Connell Benjamin P. , Wiley Erin 
Published: October 2023

AbstractAs heatwave frequency increases, they are more likely to coincide with other disturbances like insect defoliation. But it is unclear if high temperatures after defoliation impact canopy recovery or leaf traits which may affect response to further stressors like drought. To examine these stressor interactions, we subjected defoliated (DEF) and undefoliated (UNDEF) oak saplings to a simulated spring heatwave of +10°C for 25 days. We measured gas exchange, leaf area recovery, carbohydrate storage, turgor loss point (ΨTLP), and minimum leaf conductance (gmin). During the heatwave, stem respiration exhibited stronger thermal acclimation in DEF than UNDEF saplings, while stomatal conductance and net photosynthesis increased. The heatwave did not affect leaf area recovery or carbohydrate storage of DEF saplings, but reflush leaves had higher gmin than UNDEF leaves, and this was amplified by the heatwave. Across all treatments, higher gmin was associated with higher daytime stomatal conductance and a lower ΨTLP. The results suggest defoliation stress may not be exacerbated by higher temperatures. However, reflush leaves are less conservative in their water use, limiting their ability to minimise water loss. While lower ΨTLP could help DEF trees maintain gas exchange under mild drought, they may be more vulnerable to dehydration under severe drought.
There's no going back? The influence of prior entrepreneurial experience timing on voluntary turnover in post‐entrepreneurship wage employment
Authors: Zhan Siran , Zhang Liwen , Li Xueheng , Wu Yu 
Published: October 2023

AbstractDespite the prevalent stereotype that former entrepreneurs are undesirable employees due to a high likelihood of quitting, little research has empirically verified its accuracy. With a growing population of former entrepreneurs in the workforce, it has become more important than ever to understand whether, when, and which former entrepreneurs may or may not be likely to quit their post‐entrepreneurship employment. We used a sample of nationally representative 20‐year data from Australia to examine how timing of prior entrepreneurial experience relative to a focal wage job relates to voluntary turnover via a serial mediation by entrepreneurial intention and turnover intention. Results showed that employees with entrepreneurial experience in their second most recent job spell were more likely to develop entrepreneurial intention and turnover intention in sequence, which, in turn, increased quitting risk relative to employees without entrepreneurial experience in the same job spell. However, we did not find evidence for such differences between employees with and without entrepreneurial experience in their most recent job spell. Moreover, the serial mediation effect holds among men but not women. These findings highlight the important role of timing in the relationship between of entrepreneurial experience and post‐entrepreneurship employment attitude and behavior. Theoretical contributions and practical implications are discussed.
Pandemics and economic turmoil in the short‐run: The role of fiscal space
Authors: Jalles João Tovar 
Published: October 2023

AbstractWe estimate, by means of the local projection method, the short to medium‐term economic impact of previous pandemics in a sample of 170 countries during the 2000–2018 period. We find that the output effect has been significant (reaching over −2 percent after 5 years) and persistent. The impact has varied across income groups, with pandemics affecting more developed countries through a big negative impact on investment. Moreover, we explored the relevance of fiscal space in affecting the negative economic impact of pandemics. To this end, we constructed new aggregate fiscal space variables based on a principal component analysis that combined several indicators. Results suggest that the initial fiscal landscape of countries was a key ingredient in softening the economic impact of past pandemics. We believe that this paper's findings are useful to inform policymakers about what can be expected in the new normal that is following the recent COVID‐19 pandemic, particularly in a context of increasingly constrained fiscal space.
Naturally menstruating women exhibit lower cardiovagal baroreflex sensitivity than oral contraceptive users during the lower hormone phase
Authors: Mascone Sara E. , Jacob Dain W. , Eagan Lauren E. , Harper Jennifer L. , Limberg Jacqueline K. , Ranadive Sushant M. 
Published: October 2023

AbstractThe present study evaluated cardiovagal baroreflex sensitivity (BRS) across the menstrual/pill cycle in naturally menstruating women (NAT women) and women using oral hormonal contraceptives (OCP women). In 21 NAT women (23 ± 4 years old) and 22 OCP women (23 ± 3 years old), cardiovagal BRS and circulating concentrations of estradiol and progesterone were evaluated during the lower hormone (early follicular/placebo pill) and higher hormone (late follicular to early luteal/active pill) phases. During the lower hormone phase, cardiovagal BRS up, down and mean gain were lower in NAT women (15.6 ± 8.3, 15.2 ± 6.1 and 15.1 ± 7.1 ms/mmHg) compared with OCP women (24.7 ± 9.4, 22.9 ± 8.0 and 23.0 ± 8.0 ms/mmHg) (P = 0.003, P = 0.002 and P = 0.003, respectively), and higher oestrogen (R2 = 0.15, P = 0.024), but not progesterone (R2 = 0.06, P = 0.18), concentrations were predictive of lower BRS mean gain. During the higher hormone phase, higher progesterone concentrations were predictive of lower BRS mean gain (R2 = 0.12, P = 0.024). A multivariate regression model revealed group (NAT or OCP) to be a significant predictor of cardiovagal BRS mean gain in the lower hormone phase when hormone concentrations were adjusted for (R2 = 0.36, P = 0.0044). The multivariate regression model was not significant during the higher hormone phase (P > 0.05). In summary, cardiovagal BRS is lower in NAT compared with OCP women during the lower hormone phase of the menstrual/pill cycle and might be associated with higher oestrogen concentrations. In contrast, during the higher hormone phase of the menstrual/OCP cycle, higher progesterone concentrations were predictive of lower cardiovagal BRS.
Cost-Utility of an Exercise Referral Scheme Versus Doing Nothing in Flemish Adults: Exploring the Impact of Key Assumptions
Authors: Werbrouck Amber , Schmidt Masja , Putman Koen , Simoens Steven , Verhaeghe Nick , Annemans Lieven 
Published: October 2023

Background: This health-economic evaluation assessed the cost-effectiveness of an exercise referral scheme (ERS) versus doing nothing in the Flemish region (Belgium), with a particular focus on the impact of several scenarios. Methods: A 14-state Markov model was applied to compare the expected costs and quality-adjusted life years (QALYs) of 2 alternatives: the Flemish ERS (2019 data, mean age 52 y, 69.1% women) and doing nothing. A health care payer perspective was adopted and a lifetime time horizon was applied. A set of 18 scenario analyses is presented. In addition, univariate and probabilistic sensitivity analyses were performed. Results: Under the assumptions selected for the base-case analysis, the Flemish ERS is moderately cost-effective compared with doing nothing, with an incremental cost-utility ratio of €28,609/QALY. Based on the scenario analyses, the results largely depend on the assumptions regarding the continuation of the intervention effect and the frequency with which the intervention is repeated. The greatest health gains can be made when a sustainable behavioral change is achieved among participants. The probabilistic sensitivity analysis confirmed that the cost-effectiveness results were not robust. Conclusions: If it is possible to induce a sustainable behavioral change with an intervention delivered at 2- or 5-year intervals, then the Flemish ERS is potentially cost-effective compared with doing nothing (given a €40,000/QALY threshold). These results suggest the importance of repeated implementation of the program together with careful monitoring of the adherence and the sustainability of the observed effects in a real-world setting.
Draft genome sequence of

Pasteurella multocida

strain BD1769 with untypable capsular serotype isolated from a layer chicken
Authors: Hamada Kyohei , Kawashima Sachiko , Hoshinoo Kaori , Ogawa Yohsuke , Ueno Yuichi 
Published: October 2023

ABSTRACT

We report the draft genome sequence of
Pasteurella multocida
strain BD1769 (GenBank accession numbers
JARFTQ010000001
–
JARFTQ010000021
) isolated in 2021 from a layer chicken in Japan. No gene locus for capsular biosynthesis was annotated in the genome of this strain.