bluuebunny/crossref_metadata_2025_split huggingface dataset:
Early Interplay of Smell and Sight in Human Development: Insights for Early Intervention With High-Risk Infants
Authors: Purpura Giulia , Petri Stefania 
Published: November 2023

Abstract
Purpose of Review
In this narrative review, the early interplay between olfaction and vision is analysed, highlighting clinical effects of its manipulation in typical subjects and in presence of visual disorders. In addition, new methods of early intervention, based on this multisensory interaction, and their applications on different infant populations at risk of neurodevelopmental disabilities are discussed.

Recent Findings
Multisensory processes permit combinations of several inputs, coming from different sensory systems, playing a key role in human neurodevelopment, and permitting an adequate and efficient interaction with the environment. In particular, during the early stages of life, the olfactory and the visual systems appear to interact to facilitate the adaptation and the mutual bond with the caregiver and to mediate the development of social attention of the infant, although, at birth, the olfactory system is much more mature than the visual system.

Summary
Although the results from this line of research are promising, mechanisms at the basis of this interlink between sight and smell are unclear, so more work needs to be done before concluding that a multisensory approach, based on visual and olfactory stimulations, is applicable in clinical practice.
Croizat’s form-making, RNA networks, and biogeography
Authors: Mahlfeld Karin , Parenti Lynne R. 
Published: November 2023

AbstractAdvances in technology have increased our knowledge of the processes that effect genomic changes and of the roles of RNA networks in biocommunication, functionality, and evolution of genomes. Natural genetic engineering and genomic inscription occur at all levels of life: cell cycles, development, and evolution. This has implications for phylogenetic studies and for biogeography, particularly given the general acceptance of using molecular clocks as arbiters between vicariance and dispersal explanations in biogeography. Léon Croizat’s development of panbiogeography and his explanation for the distribution patterns of organisms are based on concepts of dispersal, differential form-making, and ancestor that differ from concepts of descent used broadly in phylogenetic and biogeographic studies. Croizat’s differential form-making is consistent with the extensive roles ascribed to RNAs in development and evolution and recent discoveries of genome studies. Evolutionary-developmental biology (evo-devo), including epigenetics, and the role of RNAs should be incorporated into biogeography.
Recent trends in synthesis of 2D MXene-based materials for sustainable environmental applications
Authors: Verma Ritesh , Sharma Ankush , Dutta Vishal , Chauhan Ankush , Pathak Dinesh , Ghotekar Suresh 
Published: November 2023

AbstractThe unique properties of two-dimensional (2D) materials have piqued the interest of the technical community. Titanium carbide (MXene) is a member of a rapidly expanding family of 2D materials with exceptional physiochemical characteristics and a wide range of uses in the environmental field. 2D MXene has long been a topic of interest in environmental applications, including wastewater treatment, electromagnetic interference (EMI) shielding, photocatalysis, and hydrogen evolution reactions (HER) due to its high conductivity, varied band gap, hydrophilic nature, and exceptional structural stability. This study covers important developments in 2D MXene and discusses how design, synthetic methods, and stability have changed over time. In this review paper, we have discussed the strategy synthesizing of conventional, affordable heterojunctions and Schottky junctions, as well as the development, mechanisms, and trends in the deterioration of environmental organic contaminants, HER, and EMI Shielding. We also explore the obstacles and restrictions that prevent the scientific community from producing practical MXene with regulated characteristics and structures for environmental applications and analyzing its present usage. The hazardous-environmental aspects of MXene-based materials and the problems and future possibilities of these applications are also examined and emphasized. This review paper focused on environmental applications such as heavy metal detection and removal, EMI shielding, and hydrogen generation using MXenes. The issues related to wastewater, electromagnetic interference, and clean energy production are very persistent in the environment, and a better material is required to address these challenges. Thus, MXene is a kind of material that could be a better alternative to address these persistent issues, and hence, this review becomes very important, which can pave the way for the development of MXene-based materials to address these issues.
Graphical abstract
Incorporation of N-doped biochar into zero-valent iron for efficient reductive degradation of neonicotinoids: mechanism and performance
Authors: Li Xiangying , Zhang Xiangyu , Zhang Peng , Wang Xinhua , Sun Hongwen , Lu Yongyue , Jiao Le , Liu Chenglan 
Published: November 2023

AbstractThe extensive use of neonicotinoids on food crops for pest management has resulted in substantial environmental contamination. It is imperative to develop an effective remediation material and technique as well as to determine the evolution pathways of products. Here, novel ball-milled nitrogen-doped biochar (NBC)-modified zero-valent iron (ZVI) composites (named MNBC-ZVI) were fabricated and applied to degrading neonicotinoids. Based on the characterization results, NBC incorporation introduced N-doped sites and new allying heterojunctions and achieved surface charge redistribution, rapid electron transfer, and higher hydrophobicity of ZVI particles. As a result, the interaction between ZVI particles and thiamethoxam (a typical neonicotinoid) was improved, and the adsorption–desorption and reductive degradation of thiamethoxam and ·H generation steps were optimized. MNBC-ZVI could rapidly degrade 100% of 10 mg·L−1 thiamethoxam within 360 min, its reduction rate constant was 12.1-fold greater than that of pristine ZVI, and the electron efficiency increased from 29.7% to 57.8%. This improved reactivity and selectivity resulted from increased electron transfer, enhanced hydrophobicity, and reduced accumulation of iron mud. Moreover, the degradation of neonicotinoids occurred mainly via nitrate reduction and dichlorination, and toxicity tests with degradation intermediates revealed that neonicotinoids undergo rapid detoxification. Remarkably, MNBC-ZVI also presented favorable tolerance to various anions, humic acid, wastewater and contaminated soil, as well as high reusability. This work offers an efficient and economic biochar-ZVI remediation technology for the rapid degradation and detoxification of neonicotinoids, significantly contributes to knowledge on the relevant removal mechanism and further advances the synthesis of highly reactive and environmentally friendly materials.
Graphical Abstract
Tumor heterogeneity and immune-evasive T follicular cell lymphoma phenotypes at single-cell resolution
Authors: Suma Sakurako , Suehara Yasuhito , Fujisawa Manabu , Abe Yoshiaki , Hattori Keiichiro , Makishima Kenichi , Sakamoto Tatsuhiro , Sawa Aya , Bando Hiroko , Kaji Daisuke , Sugio Takeshi , Kato Koji , Akashi Koichi , Matsue Kosei , Carreras Joaquim , Nakamura Naoya , Suzuki Ayako , Suzuki Yutaka , Ito Ken , Shiiba Hiroyuki , Chiba Shigeru , Sakata-Yanagimoto Mamiko 
Published: November 2023

AbstractT follicular helper (TFH) cell lymphomas (TFHLs) are characterized by TFH-like properties and accompanied by substantial immune-cell infiltration into tumor tissues. Nevertheless, the comprehensive understanding of tumor-cell heterogeneity and immune profiles of TFHL remains elusive. To address this, we conducted single-cell transcriptomic analysis on 9 lymph node (LN) and 16 peripheral blood (PB) samples from TFHL patients. Tumor cells were divided into 5 distinct subclusters, with significant heterogeneity observed in the expression levels of TFH markers. Copy number variation (CNV) and trajectory analyses indicated that the accumulation of CNVs, together with gene mutations, may drive the clonal evolution of tumor cells towards TFH-like and cell proliferation phenotypes. Additionally, we identified a novel tumor-cell-specific marker, PLS3. Notably, we found a significant increase in exhausted CD8+ T cells with oligoclonal expansion in TFHL LNs and PB, along with distinctive immune evasion characteristics exhibited by infiltrating regulatory T, myeloid, B, and natural killer cells. Finally, in-silico and spatial cell-cell interaction analyses revealed complex networking between tumor and immune cells, driving the formation of an immunosuppressive microenvironment. These findings highlight the remarkable tumor-cell heterogeneity and immunoevasion in TFHL beyond previous expectations, suggesting potential roles in treatment resistance.
Perovskite single-pixel detector for dual-color metasurface imaging recognition in complex environment
Authors: Xiong Jiahao , Zhang Zhi-Hong , Li Zile , Zheng Peixia , Li Jiaxin , Zhang Xuan , Gao Zihan , Wei Zhipeng , Zheng Guoxing , Wang Shuang-Peng , Liu Hong-Chao 
Published: November 2023

AbstractHighly efficient multi-dimensional data storage and extraction are two primary ends for the design and fabrication of emerging optical materials. Although metasurfaces show great potential in information storage due to their modulation for different degrees of freedom of light, a compact and efficient detector for relevant multi-dimensional data retrieval is still a challenge, especially in complex environments. Here, we demonstrate a multi-dimensional image storage and retrieval process by using a dual-color metasurface and a double-layer integrated perovskite single-pixel detector (DIP-SPD). Benefitting from the photoelectric response characteristics of the FAPbBr2.4I0.6 and FAPbI3 films and their stacked structure, our filter-free DIP-SPD can accurately reconstruct different colorful images stored in a metasurface within a single-round measurement, even in complex environments with scattering media or strong background noise. Our work not only provides a compact, filter-free, and noise-robust detector for colorful image extraction in a metasurface, but also paves the way for color imaging application of perovskite-like bandgap tunable materials.
Vertical serpentine interconnect-enabled stretchable and curved electronics
Authors: Jiao Rui , Wang Ruoqin , Wang Yixin , Cheung Yik Kin , Chen Xingru , Wang Xiaoyi , Deng Yang , Yu Hongyu 
Published: November 2023

AbstractStretchable and curved electronic devices are a promising technology trend due to their remarkable advantages. Many approaches have been developed to manufacture stretchable and curved electronics. Here, to allow such electronics to better serve practical applications, ranging from wearable devices to soft robotics, we propose a novel vertical serpentine conductor (VSC) with superior electrical stability to interconnect functional devices through a silicon-based microfabrication process. Conformal vacuum transfer printing (CVTP) technology was developed to transfer the networked platform onto complex curved surfaces to demonstrate feasibility. The mechanical and electrical performance were investigated numerically and experimentally. The VSC interconnected network provides a new approach for stretchable and curved electronics with high stretchability and reliability.
Knockdown of TACC3 inhibits tumor cell proliferation and increases chemosensitivity in pancreatic cancer
Authors: Shi Saimeng , Guo Duancheng , Ye Longyun , Li Tianjiao , Fei Qinglin , Lin Mengxiong , Yu Xianjun , Jin Kaizhou , Wu Weiding 
Published: November 2023

AbstractPancreatic ductal adenocarcinoma (PDAC) is a highly malignant digestive tract tumor with limited clinical treatments. Transforming acidic coiled-coil-containing protein 3 (TACC3) is a component of the centrosome axis and a member of the TACC family, which affect mitosis and regulate chromosome stability and are involved in tumor development and progression. However, the role of TACC3 in PDAC remains elusive. In this study, by exploiting the TCGA database, we found that high TACC3 expression in PDAC is associated with poor prognosis. shRNA-mediated TACC3 knockdown caused S phase arrest of the cell cycle and inhibited proliferation in PDAC cell lines. Through RNA sequencing and protein co-immunoprecipitation combined with mass spectrometry, KIF11 was identified as a protein that interacts with TACC3. TACC3 stabilizes and regulates KIF11 protein expression levels in PDAC cells through physical interaction. Knockdown of TACC3 or KIF11 resulted in abnormal spindle formation during cell division both in vitro and in vivo. Pharmacological inhibition of TACC3 or KIF11 can suppress tumor cell proliferation and promote apoptosis. Our studies further demonstrated that high expression of TACC3 and KIF11 mediated the resistance of PDAC to gemcitabine, and deficiency of TACC3 or KIF11 increased the sensitivity of PDAC cells to chemotherapy. In conclusion, our study reveals the fundamental role of TACC3 expression in PDAC cell proliferation and chemoresistance, suggesting that TACC3 can be used as a molecular marker to evaluate the prognosis of PDAC.
A papain-like cysteine protease-released small signal peptide confers wheat resistance to wheat yellow mosaic virus
Authors: Liu Peng , Shi Chaonan , Liu Shuang , Lei Jiajia , Lu Qisen , Hu Haichao , Ren Yan , Zhang Ning , Sun Congwei , Chen Lu , Jiang Yaoyao , Feng Lixiao , Zhang Tianye , Zhong Kaili , Liu Jiaqian , Zhang Juan , Zhang Zhuo , Sun Bingjian , Chen Jianping , Tang Yimiao , Chen Feng , Yang Jian 
Published: November 2023

AbstractWheat yellow mosaic virus (WYMV), a soil-borne pathogen, poses a serious threat to global wheat production. Here, we identify a WYMV resistance gene, TaRD21A, that belongs to the papain-like cysteine protease family. Through genetic manipulation of TaRD21A expression, we establish its positive role in the regulation of wheat to WYMV resistance. Furthermore, our investigation shows that the TaRD21A-mediated plant antiviral response relies on the release of a small peptide catalyzed by TaRD21A protease activity. To counteract wheat resistance, WYMV-encoded nuclear inclusion protease-a (NIa) suppress TaRD21A activity to promote virus infection. In resistant cultivars, a natural variant of TaRD21A features a alanine to serine substitution and this substitution enables the phosphorylation of Serine, thereby weakening the interaction between NIa and TaRD21A, reinforcing wheat resistance against WYMV. Our study not only unveils a WYMV resistance gene but also offers insights into the intricate mechanisms underpinning resistance against WYMV.
Power laws in species’ biotic interaction networks can be inferred from co-occurrence data
Authors: Galiana Nuria , Arnoldi Jean-François , Mestre Frederico , Rozenfeld Alejandro , Araújo Miguel B. 
Published: November 2023

AbstractInferring biotic interactions from species co-occurrence patterns has long intrigued ecologists. Yet recent research revealed that co-occurrences may not reliably represent pairwise biotic interactions. We propose that examining network-level co-occurrence patterns can provide valuable insights into community structure and assembly. Analysing ten bipartite networks of empirically sampled biotic interactions and associated species spatial distribution, we find that approximately 20% of co-occurrences correspond to actual interactions. Moreover, the degree distribution shifts from exponential in co-occurrence networks to power laws in networks of biotic interactions. This shift results from a strong interplay between species’ biotic (their interacting partners) and abiotic (their environmental requirements) niches, and is accurately predicted by considering co-occurrence frequencies. Our work offers a mechanistic understanding of the assembly of ecological communities and suggests simple ways to infer fundamental biotic interaction network characteristics from co-occurrence data.
Heart rhythm complexity analysis in patients with inferior ST-elevation myocardial infarction
Authors: Tang Shu-Yu , Ma Hsi-Pin , Lin Chen , Lo Men-Tzung , Lin Lian-Yu , Chen Tsung-Yan , Wu Cho-Kai , Chiang Jiun-Yang , Lee Jen-Kuang , Hung Chi-Sheng , Liu Li-Yu Daisy , Chiu Yu-Wei , Tsai Cheng-Hsuan , Lin Yen-Tin , Peng Chung-Kang , Lin Yen-Hung 
Published: November 2023

AbstractHeart rhythm complexity (HRC), a subtype of heart rate variability (HRV), is an important tool to investigate cardiovascular disease. In this study, we aimed to analyze serial changes in HRV and HRC metrics in patients with inferior ST-elevation myocardial infarction (STEMI) within 1 year postinfarct and explore the association between HRC and postinfarct left ventricular (LV) systolic impairment. We prospectively enrolled 33 inferior STEMI patients and 74 control subjects and analyzed traditional linear HRV and HRC metrics in both groups, including detrended fluctuation analysis (DFA) and multiscale entropy (MSE). We also analyzed follow-up postinfarct echocardiography for 1 year. The STEMI group had significantly lower standard deviation of RR interval (SDNN), and DFAα2 within 7 days postinfarct (acute stage) comparing to control subjects. LF power was consistently higher in STEMI group during follow up. The MSE scale 5 was higher at acute stage comparing to control subjects and had a trend of decrease during 1-year postinfarct. The MSE area under scale 1–5 showed persistently lower than control subjects and progressively decreased during 1-year postinfarct. To predict long-term postinfarct LV systolic impairment, the slope between MSE scale 1 to 5 (slope 1–5) had the best predictive value. MSE slope 1–5 also increased the predictive ability of the linear HRV metrics in both the net reclassification index and integrated discrimination index models. In conclusion, HRC and LV contractility decreased 1 year postinfarct in inferior STEMI patients, and MSE slope 1–5 was a good predictor of postinfarct LV systolic impairment.
Anopheles gambiae on remote islands in the Indian Ocean: origins and prospects for malaria elimination by genetic modification of extant populations
Authors: Ditter Robert E. , Campos Melina , Crepeau Marc W. , Pinto João , Toilibou Ali , Amina Yssouf , Tantely Luciano Michaël , Girod Romain , Lee Yoosook , Cornel Anthony J. , Lanzaro Gregory C. 
Published: November 2023

AbstractThe mosquito Anopheles gambiae s.s. is a primary malaria vector throughout sub-Saharan Africa including the islands of the Comoros archipelago (Anjouan, Grande Comore, Mayotte and Mohéli). These islands are located at the northern end of the Mozambique Channel in eastern Africa. Previous studies have shown a relatively high degree of genetic isolation between the Comoros islands and mainland populations of A. gambiae, but the origin of the island populations remains unclear. Here, we analyzed phylogenetic relationships among island and mainland populations using complete mitochondrial genome sequences of individual A. gambiae specimens. This work augments earlier studies based on analysis of the nuclear genome. We investigated the source population of A. gambiae for each island, estimated the number of introductions, when they occurred and explored evidence for contemporary gene flow between island and mainland populations. These studies are relevant to understanding historical patterns in the dispersal of this important malaria vector and provide information critical to assessing their potential for the exploration of genetic-based vector control methods to eliminate this disease. Phylogenetic analysis and haplotype networks were constructed from mitogenome sequences of 258 A. gambiae from the four islands. In addition, 112 individuals from seven countries across sub-Saharan Africa and Madagascar were included to identify potential source populations. Our results suggest that introduction events of A. gambiae into the Comoros archipelago were rare and recent events and support earlier claims that gene flow between the mainland and these islands is limited. This study is concordant with earlier work suggesting the suitability of these oceanic islands as appropriate sites for conducting field trial releases of genetically engineered mosquitoes (GEMs).
Salvia officinalis restores semen quality and testicular functionality in cadmium-intoxicated male rats
Authors: Basal Wesam T. , Issa Aliaa M. , Abdelalem Omnia , Omar Amel R. 
Published: November 2023

AbstractThe present study investigated the potential ability of Salvia officinalis, one of the oldest medicinal plants, to protect male rats against cadmium reproductive toxicity. Twenty-eight healthy male rats were randomly allocated into four groups (n = 7); control, Salvia-extract treated group, cadmium treated group and a group treated with both Cd and Salvia. Administration of cadmium reduced the relative testis to body weight and significantly affected sperm parameters by decreasing motility, viability, count and increasing morphological aberrations. Comet assay was used to detect DNA fragmentation in sperms of the rats exposed to Cd. Serum levels of testosterone T, follicle stimulating hormone FSH, and luteinizing hormone LH were significantly decreased. The biochemical analysis of testicular tissue showed a significant rise in Malondialdehyde MDA level coupled with a decrease in the activity of antioxidant enzymes (superoxide dismutase SOD, glutathione peroxidase GPx and catalase CAT). The histological examination of testis sections after Cd administration revealed severe degeneration of spermatogenic cells. Seminiferous tubules were filled with homogenous eosinophilic fluid associated with atrophy of other seminiferous tubules. Co-treatment with the Salvia officinalis extract restored the oxidative enzymes activities and decreased the formation of lipid peroxidation byproduct, which in turn ameliorated the effect of Cd on sperm parameters, DNA damage and testis histopathology. Taken together, it can be concluded that the synergistic antioxidant and radical savaging activities of Salvia officinalis prevented the effect of Cd on semen quality, sperm DNA damage, along with the oxidative stress and histological abnormalities in the testis tissues.