bluuebunny/crossref_metadata_2025_split huggingface dataset:
A review and synthesis of the benefits, drawbacks, and considerations of using traps to survey fish and decapods
Authors: Bacheler Nathan M 
Published: December 2023

Abstract
Traps (or pots) are one of the oldest and most widespread scientific survey gears for fish and decapod crustaceans around the world. Here, I review and synthesize the extensive scientific literature describing the various benefits and drawbacks of using traps as a survey gear in scientific studies. The widespread use of traps in fish and decapod surveys is due to several characteristics like their low cost, flexible design, ease of use, ability to fish unattended, and being amenable to pairing with other gears. However, there are a number of significant drawbacks of using traps, including highly variable catches due to environmental fluctuations or behavioral interactions or lost traps that continue catching and killing animals, that must be considered and accounted for when initiating trap surveys. This study highlights the types of habitats and species most and least suited for monitoring by traps, and emphasizes the importance of matching the goals and objectives of a trap survey with the correct trap design, mouth entrance, bait type, soak time, and pairing of gears. Pilot studies are also recommended before surveys are initiated to quantify the selectivity patterns of traps and identify the various factors that may influence trap catch.
Memory Entrepreneurship: Armenian Genocide Recognition in Europe
Authors: Fittante Daniel 
Published: December 2023

Abstract
Scholars have analyzed how political actors appropriate Holocaust-related memory laws to whitewash the past and undermine democratic traditions in various European countries. However, political actors in Europe have debated several other memory laws, which far-right MPs appropriate to serve their own purposes. The recognition of the Armenian Genocide is an understudied example of this phenomenon. Drawing from data collected in four countries—Bulgaria, the Czech Republic, Latvia, and Sweden—this analysis introduces the rhetorical strategies of memory justification and memory extrapolation to examine how far-right MPs, in very distinct geopolitical contexts, appropriate and instrumentalize Armenian Genocide memory to attack pluralism and promote their own versions of Europe. Through an analysis of the instrumentalization of the Armenian Genocide, this article examines a growing crisis at the center of contemporary European politics. This crisis, which involves actors promoting very different goals and values, increasingly threatens the socio-political cohesion of Europe.
Patterns of care for brachytherapy in Japan
Authors: Ikushima Hitoshi , Ii Noriko , Noda Shin-ei , Masui Koji , Murakami Naoya , Yoshida Ken , Watanabe Miho , Kawamura Shinnji , Kojima Toru , Nomoto Yoshihito , Toita Takafumi , Ohno Tatsuya , Sakurai Hideyuki , Onishi Hiroshi 
Published: December 2023

Abstract
This study aimed to assess the current state of brachytherapy (BT) resources, practices and resident education in Japan. A nationwide survey was undertaken encompassing 177 establishments facilitating BT in 2022. Questionnaires were disseminated to each BT center, and feedback through online channels or postal correspondence was obtained. The questionnaire response rate was 90% (159/177), and every prefecture had a response in at least one center. The number of centers in each prefecture ranged from 0.6 to 3.6 (median: 1.3) per million population. The annual number of patients in each center ranged from 0 to 272 (median: 31). While most prefectures provided intracavitary (IC) BT for gynecological cancers and interstitial (IS) BT for prostate cancer, only one-third of the prefectures provided IS BT for cancer sites other than the prostate. The institutional image-guided BT implementation rate was 71%. IC and IS BT was performed for 15.4% of IC BT cases of gynecological cancer. Only 47% of the BT training centers answered that they could provide adequate training in BT for residents. The most common reason for this finding was the insufficient number of patients in each center. The results show that, although BT has achieved uniformity in terms of facility penetration, new technologies are not yet widespread enough. Furthermore, IS BT, which requires advanced skills, is limited to a few BT centers, and considerable number of BT training centers do not have sufficient caseloads to provide the necessary experience for their residents.
The potential overdose of heart and left anterior descending coronary artery region during intensity-modulated radiation therapy in patients with esophageal cancer
Authors: Makita Kenji , Hamamoto Yasushi , Kanzaki Hiromitsu , Nagasaki Kei 
Published: December 2023

Abstract
This study aimed to investigate the changes in dose distribution in the heart and left anterior descending coronary artery region (LADR) during intensity-modulated radiation therapy (IMRT) in patients with esophageal cancer (EC) treated at our institution. The heart and LADR were delineated on the initial and off-cord boost planning computed tomography (CT) images. Cardiac volume reduction (CVR) was defined as the reduction in cardiac volume between the initial CT and off-cord boost CT at the dose of 36 Gy irradiated. The involved field IMRT plan was created based on each initial and off-cord boost CT image and was analyzed based on the relationship between CVR and heart and LADR dose–volume parameters (Heart-Dmax, Heart-Dmean, Heart-V20, Heart-V30, Heart-V40, LADR-Dmax, LADR-Dmean, LADR-V15 and LADR-V30). Forty patients with EC were investigated between January 2016 and January 2022. The median CVR ratio during radiation therapy (RT) was 5.57% (range, −7.79 to 18.26%). Simple linear regression analysis revealed significant correlations between CVR during RT and changes in the heart and LADR dose–volume parameters. Some patients (&gt;10%) experienced severe changes in the heart and LADR dose distribution. In three cases with reduced heart volume and primary tumor mass, the changes in LADR-V15 and LADR-V30 showed outliers. In conclusion, CVR during RT correlated with an increase in the heart and LADR dose. When both CVR and tumor volume reduction are large, a potential overdose of LADR during RT should be noted in the IMRT era.
Dilemmas faced by judges when granting marriage dispensations for child marriages in West Java, Indonesia
Authors: Shahrullah Rina Shahriyani , Firdaus Firdaus , Syarief Elza , Rahmadhony Aditya , Situmeang Ampuan , Nasution Sri Lilestina , Nurlaily Nurlaily , Kistiana Sari , Nugraha Deden Gumilar 
Published: December 2023

Abstract
Child marriage remains common in Indonesia, particularly in West Java. The highest number of child marriages is seen in the Tasikmalaya and Indramayu regencies. We argue that although the Marriage Law has been amended and the age of marriage consent increased to 19 years to prevent child marriage, the law fails to eliminate child marriages as it allows for a marriage dispensation under emergency conditions, such as a minor’s premarital pregnancy. This article is based on empirical research that employs sociolegal approaches to examine the grounds adopted by judges when deciding whether to grant or reject marriage dispensation applications in these two regencies. It was found that judges face dilemmas in examining the applications because they must prioritize the best interests of the children. As a result, their decisions are made by considering emergency and non-emergency conditions related to the child. Legal instruments are found to be more comprehensive in Tasikmalaya than in Indramayu. However, their implementation continues to be ineffective in eliminating child marriage.
A search for auroral radio emission from β Pictoris b
Authors: Shiohira Yuta , Fujii Yuka , Kita Hajime , Kimura Tomoki , Terada Yuka , Takahashi Keitaro 
Published: December 2023

ABSTRACT
Magnetized exoplanets can serve as the source of auroral radio emissions, allowing us to characterize the magnetospheric properties of these planets. Successful detections of auroral radio emissions from brown dwarfs, as well as from Jupiter, suggest that Jupiter-like planets in distant orbits may also generate radio emissions through a similar mechanism. In this study, we present our search for 250–500 MHz emissions from β Pictoris b, one of the most extensively studied young Jupiter-like planets. We conducted the search using the upgraded Giant Meterwave Radio Telescope. Despite the favourable orbital inclination, no signal was detected, putting 3σ upper limits on the radiation at 0.18 mJy. We translate this limit into constraints on the ionospheric and magnetospheric parameters, assuming that the emission is powered by the Hill current system. While the upper limit is larger by a factor of a few than the nominal estimate of radio intensity, we put constraints on the magnetospheric and ionospheric parameters.
Genetic variation is a key determinant of chromatin accessibility and drives differences in the regulatory landscape of C57BL/6J and 129S1/SvImJ mice
Authors: Mononen Juho , Taipale Mari , Malinen Marjo , Velidendla Bharadwaja , Niskanen Einari , Levonen Anna-Liisa , Ruotsalainen Anna-Kaisa , Heikkinen Sami 
Published: December 2023

Abstract
Most common genetic variants associated with disease are located in non-coding regions of the genome. One mechanism by which they function is through altering transcription factor (TF) binding. In this study, we explore how genetic variation is connected to differences in the regulatory landscape of livers from C57BL/6J and 129S1/SvImJ mice fed either chow or a high-fat diet. To identify sites where regulatory variation affects TF binding and nearby gene expression, we employed an integrative analysis of H3K27ac ChIP-seq (active enhancers), ATAC-seq (chromatin accessibility) and RNA-seq (gene expression). We show that, across all these assays, the genetically driven (i.e. strain-specific) differences in the regulatory landscape are more pronounced than those modified by diet. Most notably, our analysis revealed that differentially accessible regions (DARs, N = 29635, FDR &lt; 0.01 and fold change &gt; 50%) are almost always strain-specific and enriched with genetic variation. Moreover, proximal DARs are highly correlated with differentially expressed genes. We also show that TF binding is affected by genetic variation, which we validate experimentally using ChIP-seq for TCF7L2 and CTCF. This study provides detailed insights into how non-coding genetic variation alters the gene regulatory landscape, and demonstrates how this can be used to study the regulatory variation influencing TF binding.
IRE1 endoribonuclease signaling promotes myeloid cell infiltration in glioblastoma
Authors: Obacz Joanna , Archambeau Jérôme , Lafont Elodie , Nivet Manon , Martin Sophie , Aubry Marc , Voutetakis Konstantinos , Pineau Raphael , Boniface Rachel , Sicari Daria , Pelizzari-Raymundo Diana , Ghukasyan Gevorg , McGrath Eoghan , Vlachavas Efstathios-Iason , Le Gallo Matthieu , Le Reste Pierre Jean , Barroso Kim , Fainsod-Levi Tanya , Obiedat Akram , Granot Zvi , Tirosh Boaz , Samal Juhi , Pandit Abhay , Négroni Luc , Soriano Nicolas , Monnier Annabelle , Mosser Jean , Chatziioannou Aristotelis , Quillien Véronique , Chevet Eric , Avril Tony 
Published: December 2023

Abstract

Background
Intrinsic or environmental stresses trigger the accumulation of improperly folded proteins in the endoplasmic reticulum (ER), leading to ER stress. To cope with this, cells have evolved an adaptive mechanism named the unfolded protein response (UPR) which is hijacked by tumor cells to develop malignant features. Glioblastoma (GB), the most aggressive and lethal primary brain tumor, relies on UPR to sustain growth. We recently showed that IRE1 alpha (referred to IRE1 hereafter), 1 of the UPR transducers, promotes GB invasion, angiogenesis, and infiltration by macrophage. Hence, high tumor IRE1 activity in tumor cells predicts a worse outcome. Herein, we characterized the IRE1-dependent signaling that shapes the immune microenvironment toward monocytes/macrophages and neutrophils.

Methods
We used human and mouse cellular models in which IRE1 was genetically or pharmacologically invalidated and which were tested in vivo. Publicly available datasets from GB patients were also analyzed to confirm our findings.

Results
We showed that IRE1 signaling, through both the transcription factor XBP1s and the regulated IRE1-dependent decay controls the expression of the ubiquitin-conjugating E2 enzyme UBE2D3. In turn, UBE2D3 activates the NFκB pathway, resulting in chemokine production and myeloid infiltration in tumors.

Conclusions
Our work identifies a novel IRE1/UBE2D3 proinflammatory axis that plays an instrumental role in GB immune regulation.
Intrapancreatic fat deposition and nutritional treatment: the role of various dietary approaches
Authors: Della Pepa Giuseppe , Salamone Dominic , Testa Roberta , Bozzetto Lutgarda , Costabile Giuseppina 
Published: December 2023

Abstract
Ectopic fat accumulation in various organs and tissues, such as the liver, muscle, kidney, heart, and pancreas, is related to impaired capacity of adipose tissue to accumulate triglycerides, as a consequence of overnutrition and an unhealthy lifestyle. Ectopic fat promotes organ dysfunction and is a key factor in the development and progression of cardiometabolic diseases. Interest in intrapancreatic fat deposition (IPFD) has developed in the last few years, particularly in relation to improvement in methodological techniques for detection of fat in the pancreas, and to growing evidence for the role that IPFD might have in glucose metabolism disorders and cardiometabolic disease. Body weight reduction represents the main option for reducing fat, and the evidence consistently shows that hypocaloric diets are effective in reducing IPFD. Changes in diet composition, independently of changes in energy intake, might offer a more feasible and safe alternative treatment to energy restriction. This current narrative review focused particularly on the possible beneficial role of the diet and its nutrient content, in hypocaloric and isocaloric conditions, in reducing IPFD in individuals with high cardiometabolic risk, highlighting the possible effects of differences in calorie quantity and calorie quality. This review also describes plausible mechanisms by which the various dietary approaches could modulate IPFD.
The Limits of the Constant-rate Birth–Death Prior for Phylogenetic Tree Topology Inference
Authors: Khurana Mark P , Scheidwasser-Clow Neil , Penn Matthew J , Bhatt Samir , Duchêne David A 
Published: December 2023

Abstract
Birth–death models are stochastic processes describing speciation and extinction through time and across taxa and are widely used in biology for inference of evolutionary timescales. Previous research has highlighted how the expected trees under the constant-rate birth–death (crBD) model tend to differ from empirical trees, for example, with respect to the amount of phylogenetic imbalance. However, our understanding of how trees differ between the crBD model and the signal in empirical data remains incomplete. In this Point of View, we aim to expose the degree to which the crBD model differs from empirically inferred phylogenies and test the limits of the model in practice. Using a wide range of topology indices to compare crBD expectations against a comprehensive dataset of 1189 empirically estimated trees, we confirm that crBD model trees frequently differ topologically compared with empirical trees. To place this in the context of standard practice in the field, we conducted a meta-analysis for a subset of the empirical studies. When comparing studies that used Bayesian methods and crBD priors with those that used other non-crBD priors and non-Bayesian methods (i.e., maximum likelihood methods), we do not find any significant differences in tree topology inferences. To scrutinize this finding for the case of highly imbalanced trees, we selected the 100 trees with the greatest imbalance from our dataset, simulated sequence data for these tree topologies under various evolutionary rates, and re-inferred the trees under maximum likelihood and using the crBD model in a Bayesian setting. We find that when the substitution rate is low, the crBD prior results in overly balanced trees, but the tendency is negligible when substitution rates are sufficiently high. Overall, our findings demonstrate the general robustness of crBD priors across a broad range of phylogenetic inference scenarios but also highlight that empirically observed phylogenetic imbalance is highly improbable under the crBD model, leading to systematic bias in data sets with limited information content.
Leadership development training for orthopaedic trauma surgeons: an international survey
Authors: MacKechnie Madeline C. , Miclau Elizabeth , MacKechnie Michael A. , Miclau Theodore ,   Leadership Development Study Group (Corporate Authors)
Published: December 2023

Purpose:
This study examined the leadership development themes that global orthopaedic surgeons in differently resourced countries perceive as essential components and evaluated barriers to attending leadership development programs.

Methods:
This multinational, 45-question survey engaged orthopaedic surgeons (one expert per country). The questionnaire collected participants' demographics, perception of effective leadership traits, and valuation of various leadership themes based on importance and interest.

Results:
The survey was completed by 110 orthopaedic surgeons worldwide. Respondents most commonly reported holding a leadership position (87%) in hospital settings (62%), clinical settings (47%), and national orthopaedic societies (46%). The greatest proportion of participants reported having never attended a leadership course (42%). Participants regarded “high performing team-building,” “professional ethics,” and “organizational structure and ability to lead” as the most important leadership themes. No significant (P ≤ 0.05) differences were identified among perceived importance or interest in leadership themes between income levels; however, statistically significant differences were identified in the questionnaire; respondents in low- and middle-income countries (LICs/LMICs) demonstrated a stronger interest in attending a leadership course than those in high-income countries (HICs) (98% vs. 79%, P = 0.013), and fewer surgeons in LICs/LMICs had taken personality assessment tests than those in HICs (22% vs. 49%, P = 0.019). The most common barriers to attending leadership courses were lack of opportunities and invitations (57%), difficulty missing work (22%), and cost of course attendance (22%).

Conclusions:
These findings can better inform the development of effective curricula and provide a framework for a successful model for the future.

Level of Evidence:
V.
HPV vaccination among eligible HIV-positive adults: a best practice implementation project
Authors: Walker Holly , Garbo Candon , Palokas Michelle 
Published: December 2023

ABSTRACT

Objective:
The aim of this best practice implementation project was to promote evidence-based practices (EBPs) for human papilloma virus (HPV) vaccination among eligible HIV-positive patients.

Introduction:
HPV-induced cancers are largely preventable through the prophylactic vaccination of HPV-naïve individuals. Immunosuppression in HIV-positive patients prevents clearance of HPV, which increases the risk of developing cancer. Health care agencies caring for individuals living with HIV must implement interventions to enhance uptake of HPV vaccination.

Methods:
This project was guided by the JBI Model of Evidence-Based Healthcare and JBI's Getting Research into Practice (GRiP) tool. A baseline audit was conducted to assess current practice against EBPs and to identify areas for improvement. A follow-up audit was conducted post-implementation to determine whether compliance with EBPs had improved.

Results:
The baseline audit revealed an average compliance rate of 46% with the two EBPs for increasing vaccination uptake. Three barriers to compliance were identified and strategies were implemented to address these barriers. The follow-up audit revealed 71% average compliance with the EBPs, a 25% increase from baseline.

Conclusions:
Interventions aimed at promoting HPV vaccination among HIV-positive individuals can reduce the risk of specific cancers. This project revealed an increase in compliance with EBPs for HPV vaccination for eligible HIV-positive patients when a vaccination reminder and recall system was placed in a frequently visited section of the electronic health record. However, a more sustainable solution would be to collaborate with IT staff to ensure that the health maintenance section in the electronic health record is configured correctly.
Factors that influence the implementation of innovation in aged care: a scoping review
Authors: Windle Alice , Marshall Amy , de la Perrelle Lenore , Champion Stephanie , Ross Paul D.S. , Harvey Gillian , Davy Carol 
Published: December 2023

ABSTRACTObjective:The objective of this scoping review is to identify factors that influence the implementation of innovation in aged care.Introduction:Aged care is a dynamic sector experiencing rapid change. Implementation of innovations in aged care has received relatively little research attention compared with health care.Inclusion criteria:This review included studies of any design that examined the implementation of innovations in aged care settings.Methods:Searches were conducted in MEDLINE, CINAHL, AgeLine, and ProQuest Social Sciences Premium Collection for studies published between January 1, 2012 and December 31, 2022. The titles and abstracts of retrieved citations were screened by two independent reviewers. Full-text articles were screened by one reviewer to determine eligibility. Data were extracted in NVivo using a tool developed by the research team. Factors that influenced implementation were inductively coded, interpreted, and grouped into categories.Results:Of the 2530 studies that were screened, 193 were included. Of the included papers, 74% related to residential aged care, 28% used an implementation theory or framework, and 15% involved consumers. Five key categories of factors influencing implementation were identified: organizational context, including resourcing and culture; people's attitudes and capabilities; relationships between people; the intervention and its appropriateness; and implementation actions, such as stakeholder engagement or implementation strategies.Conclusions:Our findings can be used to develop practical resources to support implementation efforts, and highlight the importance of resourcing for successful implementation. Attention to community-based aged care and greater engagement with theory and community are needed to promote research rigor, relevance, and applicability.
Maf1 phosphorylation is regulated through the action of prefoldin-like Bud27 on PP4 phosphatase inSaccharomyces cerevisiae
Authors: Gutiérrez-Santiago F. , Martínez-Fernández V. , Garrido-Godino A.I , Colino-Palomino C. , Clemente-Blanco A. , Conesa C. , Acker J. , Navarro F. 
Published: December 2023

ABSTRACTBud27 is a prefoldin-like protein that participates in transcriptional regulation mediated by the three RNA polymerases inSaccharomyces cerevisiae. Lack of Bud27 significantly affects RNA pol III transcription, although the involved mechanisms have not been characterized. Here we show that Bud27 regulates the phosphorylation state of the RNA pol III transcriptional repressor, Maf1, influences its nuclear localization, and likely its activity. We demonstrate that Bud27 is associated with the Maf1 main phosphatase PP4in vivo,and that this interaction is required for proper Maf1 dephosphorylation. Lack of Bud27 decreases the interaction among PP4 and Maf1, Maf1 dephosphorylation, and its nuclear entry. Our data uncover a new nuclear function of Bud27, identify PP4 as a novel Bud27 interactor and demonstrate the effect of this prefoldin-like on the posttranslational regulation of Maf1. Finally, our data reveal a broader effect of Bud27 on PP4 activity by influencing, at least, the phosphorylation of Rad53.