bluuebunny/crossref_metadata_2025_split huggingface dataset:
Triangular Fibrocartilage Complex: An Anatomical and Medical Illustration Study
Authors: Tiburzi Hallie , Machado Carlos A. G. , D’Antoni Massimo S. , Tubbs R. Shane 
Published: January 2025

ABSTRACTRecent advances in small‐joint arthroscopy and cutting‐edge magnetic resonance imaging systems have enabled orthopedic surgeons to perform more complex repairs of the wrist. Such repairs can include those of the triangular fibrocartilage complex (TFCC) of the wrist that necessitates a reappraisal of its morphometry with special emphasis on the relationship between its articular disc (AD) and surrounding tissues. The TFCC AD is a fibrocartilaginous, biconcave structure located between the ulnar styloid process and the carpal bones of the wrist. We carefully dissected and measured the ADs of 58 wrists from 34 embalmed cadavers (20 females, 14 males) and fabricated three‐dimensional biofidelic plastic models of them. Precise measurements of the ADs were taken that included length, width, and thickness at five standardized points. For the entire sample, the mean length and width of left ADs were 18.09 and 9.60 mm, respectively, while right ADs averaged 18.63 mm in length and 9.93 mm in width. Significant differences were found between male and female ADs on the right and left sides (p < 0.05). After the data were further analyzed and casts fabricated, a medical illustrator created novel anatomical illustrations to clarify structures that form the TFCC and help illuminate its complex anatomy. Our study provides valuable morphometric data of the AD and detailed novel medical illustrations of the entire TFCC, enhancing our understanding of its morphology for both educational and clinical applications.
Real‐World Impact of Olaparib Exposure in Advanced Pancreatic Cancer Patients Harboring Germline BRCA1‐2 Pathogenic Variants
Authors: Milella Michele , Orsi Giulia , di Marco Mariacristina , Salvatore Lisa , Procaccio Letizia , Noventa Silvia , Bozzarelli Silvia , Garajova Ingrid , Vasile Enrico , Giordano Guido , Macchini Marina , Cavaliere Alessandro , Gaule Marina , Bergamo Francesca , Chiaravalli Marta , Palloni Andrea , Carloni Riccardo , Bittoni Alessandro , Niger Monica , Rapposelli Ilario Giovanni , Rodriquenz Maria Grazia , Scartozzi Mario , Mosconi Stefania , Giommoni Elisa , Bernardini Ilaria , Paratore Chiara , Spallanzani Andrea , Bencardino Katia , Forti Laura , Tamburini Emiliano , Lonardi Sara , Scarpa Aldo , Cascinu Stefano , Tortora Giampaolo , Sperduti Isabella , Reni Michele 
Published: January 2025

ABSTRACTIntroductionPancreatic cancer arising in the context of BRCA predisposition may benefit from poly(ADP‐ribose) polymerase inhibitors. We analyzed real‐world data on the impact of olaparib on survival in metastatic pancreatic cancer patients harboring germline BRCA mutations in Italy, where olaparib is not reimbursed for this indication.MethodsClinico/pathological data of pancreatic cancer patients with documented BRCA1‐2 germline pathogenic variants who had received first‐line chemotherapy for metastatic disease were collected from 23 Italian oncology departments and the impact of olaparib exposure on overall survival (OS) was analyzed.ResultsOf 114, 53 BRCA‐mutant pancreatic cancer patients had received olaparib for metastatic disease. OS was significantly longer in patients who were exposed to olaparib (hazard ratio [HR] 0.568, 95% confidence interval [CI] 0.351–0.918, log‐rank p = 0.02) in any setting/line of treatment; similar results were obtained for patients who received olaparib as maintenance treatment (in any line of treatment), patients who had stage IV disease at diagnosis, and patients who did not experience progressive disease as their best response to first‐line chemotherapy. Exposure to olaparib in the first‐line maintenance setting after platinum‐based chemotherapy, however, did not significantly impact survival. At multivariate analysis, CA19.9 levels at diagnosis and response to first‐line chemotherapy were independently prognostic; however, when response to chemotherapy was excluded, any exposure to olaparib was a significant independent predictor of longer OS, together with CA19.9 levels.ConclusionThe real‐world data presented here support the use of olaparib for metastatic disease in germline BRCA‐mutant pancreatic cancer patients, as it may significantly prolong survival.
Application of Esophageal Sponge Cytology in Screening Esophageal Squamous Cell Carcinoma in a High‐Risk Region of China
Authors: Huang Shu , Gu Xuexiang , Zhou Hailang , Feng Yadong , Shi Ruihua , Wang Wei , Zhou Aijun , Lin Jie 
Published: January 2025

ABSTRACTObjectiveTo investigate the feasibility and accuracy of esophageal sponge cytology in screening esophageal squamous cell carcinoma (ESCC).MethodsFrom May 2021 to June 2022, an opportunistic screening was performed in people aged 40–75 from a high‐risk region for ESCC. Using an esophageal cell collector that was independently developed in China for esophageal sponge cytology, a positive cytology was determined as detection of atypical squamous cells or more severe lesions. The safety, tolerability, and accuracy of esophageal sponge cytology were compared with those of pathological examination after endoscopy and biopsy.ResultsA total of 1581 eligible participants were involved in the screening program, including 61 (3.86%) with high‐grade lesions pathologically confirmed by endoscopic biopsy. No serious adverse events were reported during sampling. Major adverse events included vomiting during sampling (n = 2, 0.13%) and sore throat after sampling (n = 36, 2.27%). The majority of participants showed good tolerability and accessibility (n = 1568, 98.80%) accessed by the visual analogue scale (VAS). Esophageal sponge cytology offered a satisfactory diagnostic accuracy in screening advanced esophageal epithelial lesions, with a sensitivity of 98.36% (95%CI: 90.02%–99.91%) and a specificity of 91.15% (95%CI: 89.97%–92.84%), and a negative predictive value up to 99. 92% (95%CI: 99.53%–99.99%).ConclusionEsophageal sponge cytology is a highly feasible, safe, and accurate screening method for ESCC in a high‐risk region of China.Trial RegistrationFirst Affiliated Hospital of Naval Medical University: NCT04609813
RIOK1: A Novel Oncogenic Driver in Hepatocellular Carcinoma
Authors: Ruan Chunyan , Shang Tianyu , Zhang Sijia , Ru Wenhong , Yang Yuefeng , Shen Yi 
Published: January 2025

ABSTRACTBackgroundHepatocellular carcinoma (HCC) is one of the most common and highly lethal cancers worldwide. RIO kinase 1 (RIOK1), a protein kinase/ATPase that plays a key role in regulating translation and ribosome assembly, is associated with a variety of malignant tumors. However, the role of RIOK1 in HCC remains largely unknown.MethodsChanges in RIOK1 expression in HCC and patient prognosis were evaluated using HCC tissues and public databases. The functional role of RIOK1 in HCC was analyzed by RTCA assay, clonogenic assay, and flow cytometry in vitro, and by mouse tumor xenograft model in vivo. Potential mechanism studies were performed using multi‐omics analysis, public database screening, and qRT‐PCR assay.ResultsIn this study, we found that RIOK1 was elevated in HCC tissues and correlated with poor prognosis. Functional assays demonstrated that RIOK1 knockdown suppressed HCC cell proliferation, survival, and tumor growth in vivo, while RIOK1 overexpression enhanced these oncogenic phenotypes. Meanwhile, RIOK1 knockdown affected cell cycle progression and the expression of cyclin A2 and cyclin B1. Furthermore, integrated transcriptomic and proteomic analysis revealed that RIOK1 may promote HCC cell proliferation by affecting the cell cycle and DNA repair pathways. Moreover, we identified five potential effectors regulated by RIOK1: PMS1, SPDL1, RAD18, BARD1, and SMARCA5, which were highly expressed in HCC tissues and negatively correlated with the overall survival of HCC patients.ConclusionOur findings suggest that RIOK1 is a novel oncogenic driver that may serve as a potential diagnostic and therapeutic target for HCC.
Clients' Preferences for Their Therapists' Relational Styles in Psychotherapy: A Consensual Qualitative Research Study
Authors: Di Malta Gina , Cooper Mick , Oddli Hanne , Swift Joshua K. , Knox Sarah 
Published: January 2025

ABSTRACTBackgroundAccommodating clients' preferences is a cornerstone of evidence‐based practice. However, little is known of clients' preferences for their therapists' relational styles.MethodsWe conducted a secondary analysis focused on identifying clients' preferences for their therapists' relational styles, using original data from Cooper et al.'s (2023) consensual qualitative research (CQR) study. Initial data collection involved conducting semi‐structured interviews with a cohort of 13 clients who had completed up to 24 sessions of pluralistic psychotherapy. Of these participants, 10 identified as female and three identified as male.FindingsFour themes and six sub‐themes emerged: (1) Clients preferred their therapist to be active/not passively disengaged and to provide input, challenge and guidance (n = 10); (2) Clients preferred their therapist to display relatedness, warmth and validation (n = 8); (3) Clients preferred some flexibility, attunement and for their therapist to adapt the therapy to their unique needs (n = 5); (4) Clients preferred to be listened to, having a space to talk and to explore (n = 4).Implications for PracticeThe themes offer insights that can serve as a foundational framework for future research and contribute to the development of training programmes tailored to enhance counselling psychologists' preference work and relational styles.
Exploring Chemical Profiles, Antifeedant, Nematicidal, and Phytotoxic Potentials of Seven Essential Oils From Eucalyptus Species
Authors: Belaid Souda , Gonzalez‐Coloma Azucena , Andres Maria Fe , Elfalleh Walid , Idoudi Sourour , Romdhane Mehrez , Saadaoui Ezzeddine 
Published: January 2025

ABSTRACTLeaf essential oils (EOs) of seven Eucalyptus species planted in Southern Tunisia (E. gracilis, E. lesouefii, E. salmonophloia, E. sargentii, E. flocktoniae, E. oleosa, and E. salubris) were screened for their antifeedant, nematicidal, and phytotoxic effects as well as their chemical compositions. The yield of EOs of these species varied from 1.32% ± 0.38% to 4.92%±0.37%. Using gas chromatography mass spectrometry (GC–MS) analysis, 22 compounds were identified, representing 87.16%–96.83% of the total oil content. The main components found in all EOs were 1,8‐cineole (38.71%–70.44%), α‐pinene (4.40%–8.88%), p‐cymene (0.95%–14.99%), pinocarvone (0.17%–3.22%), trans‐pinocarveol (1.53%–13.48%), spathulenol (0.18%–5.39%), and globulol (0.22%–6.47%). The insect antifeedant, nematicidal, and phytotoxic effects of these oils against insect pests (Spodoptera littoralis, Myzus persicae, and Rhopalosiphum padi), the root‐knot nematode (Meloidogyne javanica), and two plant models (Lolium perenne and Lactuca sativa) were examined. Despite the moderate insect antifeedant activity, the EOs of E. salubris, E. salmonophloia, E. lesouefii, and E. sargentii were the most effective against M. persicae. Significant nematicidal effects were observed for both E. salmonophloia and E. oleosa EOs. Moreover, all Eucalyptus EOs significantly suppressed the root and leaf growth of L. perenne than the root length of L. sativa, indicating that EOs from Eucalyptus possessed an excellent phytotoxic potential.
The Utility and Chemotaxonomic Significance of Volatiles for Inferring Phylogeny in Chaerophyllum (Apiaceae): Essential Oil Composition of Myrrhoides nodosa (L.) Cannon
Authors: Stamenković Jelena , Petrović Goran 
Published: January 2025

ABSTRACTGas chromatography (GC) and GC/MS analysis of essential oil composition obtained from different parts of Myrrhoides nodosa (L.) Cannon has been carried out. Regarding the essential oil composition, 33 compounds have been identified in the oil isolated from the aerial parts of M. nodosa and 42 from roots (accounting for 98.2% and 96.9% of all, respectively), with germacrene d (60.7%) being the major component in aerial parts. On the other hand, the essential oils obtained from roots of M. nodosa consisted mainly of non‐terpenoid compounds with methyl eugenol (30.4%) as dominant compound. The potential use of chemical composition of essential oils as chemotaxonomic markers in determining chemotaxonomic relationships of the genus Myrrhoides, which is a monotypic genus with only one species: M. nodosa (L.) Cannon, and with those of related genus Chaerophyllum, has been discussed in detail. The obtained results fully justify the latest systematization in which the species Myrrhoides becomes member of Chaerophyllum genus again.
Discovery of Undescribed Flavonoid and Rotenoid Derivatives From the Leaves of Derris trifoliata With Their Cytotoxic Activity
Authors: Trang Bui Thi Nha , Anh Bui Thi Mai , Mai Nguyen Thi , Nga Tran Thuy , Hang Dan Thi Thuy , Tai Bui Huu , Kiem Phan Van 
Published: January 2025

ABSTRACTPhytochemical study on the leaves of Derris trifoliata led to the isolation of five rotenoids (3–7) and 10 flavonoid derivatives (1, 2, 8–15). Three of them, (2S)‐5,7‐dihydroxy‐6‐(2‐hydroxyethyl)‐2‐(4‐hydroxyphenyl)‐8‐(3‐methylbut‐2‐en‐1‐yl)chroman‐4‐one (1), keampferol 3‐O‐[6‐O‐(E)‐feruloyl‐β‐d‐glucopyranosyl]‐(1 → 2)‐O‐[α‐l‐rhamnopyranosyl‐(1 → 6)‐β‐d‐glucopyranoside (2), and (+)‐13‐homo‐13‐oxa‐6a,12a‐dehydrorotenone (3) were verified by Scifinder as previously undescribed compounds. Their chemical structures were elucidated by using infrared (IR), electronic circular dichroism (ECD), HR‐ESI‐MS, 1D, and 2D NMR methods. Compounds 1–15 were tested for their cytotoxic activities against SK‐LU‐1 and HepG2 cell lines. Compounds 4, 8, 14, and 15 showed moderate cytotoxic activities against SK‐LU‐1 cells with IC50 values ranging from 8.52 to 28.89 µM and against HepG2 cells with IC50 values ranging from 7.11 to 34.85 µM.
A Cedrane and a Fusarin From the Algicolous Fungus Fusarium graminearum 12II2N and Response to Mycoparasitism
Authors: Hou Xu‐Liang , Song Yin‐Ping , Zou Ji‐Xue , Ji Nai‐Yun 
Published: January 2025

ABSTRACTThe fungal genus Fusarium is a treasure‐trove of structurally diverse secondary metabolites, contributed greatly by marine‐derived strains. A new cedrane sesquiterpene, fusacedrol (1), and a new fusarin member, fusarin M (2), were isolated from Fusarium graminearum 12II2N that was isolated as an endophyte from the marine brown alga Sargassum sp. The planar structures of compounds 1 and 2 were incisively identified by analysis of spectroscopic data, inclusive of NMR and MS, and the relative configurations were ensured by NOESY correlations and a coupling constant. Quantum chemical calculations of specific optical rotations of compound 1 and cedrol solved the absolute configuration of compound 1. Compound 1 represents the first new cedrane derivative with a 5/5/6 tricyclic nucleus from marine‐derived fungi, and this skeleton has also been reported rarely from other marine organisms. Compound 2 is an isomer of fusarin Y, and its production could be greatly reduced by coculture with Trichoderma flagellatum 12A1N of the same origin. The two isolates were assayed for inhibiting the bacterium Pseudoalteromonas citrea (bio‐02684, a green‐spot pathogen of Porphyra), but none of them were active unfortunately.
Aromatic Polyketides From a Marine‐Derived Streptomyces Species
Authors: Shen Jingjing , Cheng Shan , Liu Zhi , Zhu Weiming , Fu Peng 
Published: January 2025

ABSTRACTThree new naphthalene derivatives, strepthalenes A–C (1–3), and the known analogue (S)‐DNPA (4), together with six previously reported anthraquinones (5–10), were isolated from the marine‐derived Streptomyces sp. OUCMDZ‐4182. Their structures were elucidated by detailed spectroscopic analysis and quantum chemical calculations. Strepthalenes B and C showed moderate activity against amyloid‐β 42 (Aβ42) aggregation with IC50 values of 47.65 and 24.73 µM, respectively.
Chemical Constituents of the Deep‐Sea‐Derived Fungus Trichoderma simmonsii ZEN3
Authors: Song Yun‐Fei , Wang Yuan , Zou Zheng‐Biao , Chao Rong , Wu Tai‐Zong , Zhong Tian‐Hua , Zhang A‐Long , Gao Cheng‐Hai , Yang Xian‐Wen 
Published: January 2025

ABSTRACTTwo new nor‐rubrofusarin derivatives (trichsimins A and B, 1 and 2) and one new chromone derivative (trichsimin C, 5) were isolated from the deep‐sea–derived Trichoderma simmonsii ZEN3 along with 20 known compounds (3, 4, and 6−23). The structures of the new compounds were established by detailed analyses of the NMR, HRESIMS, and optical rotatory dispersion (ORD) data. Nafuredin (14) exhibited potent inhibition against RSL3‐induced ferroptosis with an EC50 value of 5.54 µM.
The Ayurvedic Management of Fungal Sinusitis in Standalone Settings: A Case Report
Authors: Patel Rajanikant , Skanthesh Lakshmanan , Zaveri Vishal , Padikkal Vinayak , Ghosh Oriparambil Sivaraman Nirmal 
Published: January 2025

ABSTRACTA 42‐year‐old female with left nasal blockage, facial numbness, upper palate pain, and headache was diagnosed with fungal ball sinusitis via CT scan. Refusing surgery, she opted for Ayurveda. Comprehensive treatment led to complete symptom resolution and a clear CT scan at 3 months.
Early Detection and One‐Year Follow‐Up of Subclavian Steal Syndrome Treated With Traditional Chinese Medicine: A Case Report
Authors: Yang Wen‐Chieh 
Published: January 2025

ABSTRACTSubclavian steal syndrome (SSS) often goes undiagnosed because of its variable and subtle symptoms, highlighting the need for innovative diagnostic approaches. This case report explores the integration of traditional Chinese medicine (TCM) in both diagnosing and managing SSS, marking a pioneering contribution to the field. An 80‐year‐old woman with persistent dizziness, unresponsive to conventional treatments, underwent TCM pulse diagnosis, which revealed significant inter‐arm pulse discrepancies. Subsequent Western imaging confirmed SSS. The patient was treated with Chinese herbal medicines (CHMs) targeting Qi deficiency and blood stasis, resulting in significant symptom improvement and a reduction in inter‐arm systolic blood pressure disparities. Follow‐up over 1 year showed sustained benefits. The integration of TCM pulse diagnosis, CHMs, and Western imaging highlights their complementary roles and potential as adjunctive therapies for managing SSS, offering a novel and comprehensive therapeutic strategy.
Cutaneous involvement in multiple myeloma. A rare entity
Authors: Rapparini L. , Pileri A. , Robuffo S. , Agostinelli C. , La Placa Michelangelo 
Published: January 2025

Key Clinical MessageCutaneous involvement in multiple myeloma is rare and may present as nodules mimicking other lymphoid neoplasms. It typically occurs late in the course of the disease and is associated with an aggressive clinical course and poor prognosis.
Research Progress of Heterogeneous Co‐Based Catalysts for Olefin Hydroformylation
Authors: Wang Xiao , Wang Lingtao , Gong Hao , Chen Yifei 
Published: January 2025

AbstractThe hydroformylation reaction is a large‐scale industrial process for the synthesis of aldehydes. At present, the most widely used are Rh‐based and Co‐based catalysts in homogeneous systems. However, the catalyst separation is a critical issue leading to high cost because of the metal leaching and ligand loss. Co‐based heterogeneous catalysts have more application prospects. This review introduces the research progress of Co‐based heterogeneous catalysts in recent years from different heterogeneous strategies. It can be found that increasing the dispersion of active sites, adjusting the interaction between metal and metal or support, and changing the reaction conditions can change the reactivity and stability of the catalyst. At the end of this review, we put forward suggestions and prospects for the future research of cobalt‐based heterogeneous catalysts. It is expected to develop a catalyst with high catalytic activity, selectivity, and stability that can adapt to industrial production.
Responsive Surfactant‐Driven Morphology Transformation of Block Copolymer Microparticles
Authors: Zhang Mengmeng , Xu Yinhan , Zhu Jintao , Xu Jiangping 
Published: January 2025

AbstractBlock copolymer (BCP) microparticles, which exhibit rapid change of morphology and physicochemical property in response to external stimuli, represent a promising avenue for the development of programmable smart materials. Among the methods available for generating BCP microparticles with adjustable morphologies, the confined assembly of BCPs within emulsions has emerged as a particularly facile and versatile approach. This review provides a comprehensive overview of the role of responsive surfactants in modulating interfacial interactions at the oil‐water interface, which facilitates controlled BCP microparticle morphology. We elucidate how variations in the properties of responsive surfactants, activated by external stimuli, influence BCP chain arrangement and interfacial selectivity. Additionally, this review explores the applications of shape‐switchable microparticles in advanced technologies such as smart display, fluorescence modulation, magnetic resonance imaging, drug delivery, and photonic crystal. Finally, the challenges and prospective future directions in this rapidly evolving field are discussed.
Efficient Assembly of Cyclohexane‐Tethered Bispirooxindoles via Carboanion Relay Enabled [1 + 2 + 2 + 1] Annulation
Authors: Yuan Zi‐Yi , Zheng Zi‐Xia , Hu Xiao‐Qiang , Jia Feng‐Cheng 
Published: January 2025

Comprehensive SummaryA novel carboanion relay enabled [1 + 2 + 2 + 1] cascade cyclization reaction utilizing rarely used isatin‐derived β‐silylcarbinols and aryl methyl ketones as readily available starting materials has been developed, endowing a powerful platform for the streamline synthesis of cyclohexane‐tethered bispirooxindoles in decent yields with high diastereoselectivities. This protocol was realized by merging triple Michael additions and C—C bond cleavage using Cs2CO3 as a robust promotor under transition metal‐free conditions. The practicability of this method is demonstrated by its simple operation, broad substrate scope as well as easy scale‐up.
Phosphine‐Catalyzed Divergent γ,γ‐ and ε,γ‐Umpolung Domino Additions of Bisoxindoles with Allenoates: Construction of Vicinal All‐Carbon Quaternary Stereocenters and Formal Total Synthesis of Dimeric Cyclotryptamine Alkaloids
Authors: Zhang Yufei , Chen Jing , Yao Hui , Wang Yuanbin , Liu Hongyu , Wang Long , Huang Nianyu , Wang Nengzhong 
Published: January 2025

Comprehensive SummaryVicinal all‐carbon quaternary stereocenters are widely present in natural products and bioactive molecules. However, the construction of such motif in one step from readily available starting materials remains a significant challenge. Herein, we report a phosphine‐catalyzed divergent γ,γ‐ and ε,γ‐umpolung domino addition of bisoxindoles with allenoates. This method serves as a practical tool for the concise synthesis of a series of bisoxindole derivatives bearing sterically hindered vicinal all‐carbon quaternary stereocenters under mild reaction conditions. The applicability of this novel method was demonstrated with the gram‐scale synthesis of three known advanced intermediates for the total syntheses of calycanthine, chimonanthine and folicanthine.