bluuebunny/crossref_metadata_2025_split huggingface dataset:
Interleukin‐17 alleviates erastin‐induced alveolar bone loss by suppressing ferroptosis via interaction between NRF2 and p‐STAT3
Authors: Bao Jiaqi , Wang Zhongxiu , Yang Yuting , Yu Xufei , Yuan Wenlin , Sun Weilian , Chen Lili 
Published: November 2023

AbstractAimTo investigate the relationship between interleukin‐17 (IL‐17), ferroptosis and osteogenic differentiation.Materials and MethodsWe first analysed the changes in ferroptosis‐related molecules in experimental periodontitis models. The effects of erastin, a small‐molecule ferroptosis inducer, and IL‐17 on alveolar bone loss and repair in animal models were then investigated. Primary mouse mandibular osteoblasts were exposed to erastin and IL‐17 in vitro. Ferroptosis‐ and osteogenesis‐related genes and proteins were detected. Further, siRNA, immunofluorescence co‐localization and immunoprecipitation were used to confirm the roles of the nuclear factor erythroid‐2‐related factor 2 (NRF2) and phosphorylated signal transducer and activator of transcription 3 (p‐STAT3), as well as their interaction.ResultsThe levels of NRF2, glutathione peroxidase 4 and solute carrier family 7 member 11 were lower in the ligated tissues than in normal periodontal tissues. Alveolar bone loss in an in vivo experimental periodontitis model was aggravated by erastin and alleviated by IL‐17. In vitro, IL‐17 ameliorated erastin‐inhibited osteogenic differentiation by reversing ferroptosis. Altered NRF2 expression correlated with changes in ferroptosis‐related molecules and osteogenesis. Furthermore, the physical interaction between NRF2 and p‐STAT3 was confirmed in the nucleus. In IL‐17 + erastin‐stimulated osteoblasts, the p‐STAT3–NRF2 complex might actively participate in the downstream transcription of ferroptosis‐ and osteogenesis‐related genes.ConclusionsIL‐17 administration conferred resistance to erastin‐induced osteoblast ferroptosis and osteogenesis. The possible mechanism may involve p‐STAT3 directly interacting with NRF2.
Long‐term stability of gingival margin and periodontal soft‐tissue phenotype achieved after mucogingival therapy: A systematic review
Authors: Carbone Ana Claudia , Joly Julio Cesar , Botelho João , Machado Vanessa , Avila‐Ortiz Gustavo , Cairo Francesco , Chambrone Leandro 
Published: November 2023

AbstractBackgroundThe aim of this systematic review was two‐fold: (i) to evaluate the long‐term (≥5 years) stability of the gingival margin position, keratinized tissue width (KTW) and gingival thickness (GT) in sites that underwent root coverage (RC) or gingival augmentation (GA); and (ii) to assess the influence of different local variables on the long‐term stability of dental and gingival tissues.Materials and MethodsRandomized controlled trials (RCTs) and non‐RCTs reporting short‐term (i.e., 6–12 months after baseline surgical intervention) and long‐term (≥5 years) follow‐up data after surgical treatment of adult patients presenting single or multiple mucogingival deformities, defined as sites presenting gingival recession defects (GRDs) and/or (KTW) deficiency (i.e., <2 mm), were considered eligible for inclusion. MEDLINE–PubMed, EMBASE and Cochrane Central Register of Controlled Trials databases were searched for articles published up to 15 May 2023. Mixed‐effects multiple linear regression was used to assess the association between KTW, type of surgical procedure and time (i.e., independent variables) on the stability of the gingival margin in sites that received RC or GA therapy.ResultsOf the 2569 potentially eligible records, 41 (reporting 40 studies) met the eligibility criteria. Graphical estimates including data from all RC procedures found an upward trend in recession depth (RD) increase over time. Conversely, it was observed that in 63.63% of RC studies and in 59.32% of RC treatment arms KTW increased over time, particularly in sites treated with subepithelial connective tissue grafts (SCTGs). Conversely, sites that underwent GA procedures generally exhibited an overall reduction of KTW over time. However, sites treated with free gingival grafts (FGGs) showed a decrease in RD after 10 years of follow‐up. Three main findings derived from the pooled estimates were identified: (i) Gingival margin stability was associated with the amount of KTW present during short‐term assessment (i.e. the greater the KTW at 6–12 months after treatment, the more stable the gingival margin). (ii) The use of autogenous soft‐tissue grafts was associated with lower RD increase over time. (iii) Treatment approaches that contribute to the three‐dimensional enhancement of the gingival phenotype, as clearly demonstrated by FGG, were associated with gingival margin stability.ConclusionsThe extent of apical migration of the gingival margin appears to be directly related to the amount of KTW and GT upon tissue maturation. Interventions involving the use of autogenous grafts, either SCTG or FGG, are associated with greater short‐term KTW gain and lower RD increase over time.
A new snake eel species of the genus Ophichthus (Anguilliformes: Ophichthidae) from the southeast coast of India, Bay of Bengal, with the taxonomic account of Ophichthus chilkensis
Authors: Kodeeswaran Paramasivam , Kathirvelpandian Ayyathurai , Mohapatra Anil , Ajith Kumar Thipramalai Thangappan Pillai , Sarkar Uttam Kumar 
Published: November 2023

AbstractA new species of the ophichthid eel of the family Ophichthidae is described based on five specimens collected from the Mudasalodai fish landing center, off Cuddalore coast, southeast coast of India, Bay of Bengal. Ophichthus naevius sp. nov. is distinguished from its congeners by having a unique color pattern: dorsal body with numerous dense dark spots or patches, ventral body pale yellowish green, dorsal‐fin origin just before pectoral‐fin tip, vertebral formula: 12–14/52–53/134–138, and teeth on jaw uniserial and pointed. The study also reports the range extension and molecular evidence of Ophichthus chilkensis from South India. Molecular analyses were performed for both species, and their phylogenetic relationship suggests that the new species exhibits 10.2% genetic divergence with its congener Ophichthus sangjuensis, followed by Ophichthus brevicaudatus (10.4%), and Ophichthus sp. 1 (11.8%) also forms the closest clade in both Bayesian inference and maximum likelihood (ML) tree. Similarly, according to the topology of the ML tree, the species O. chilkensis forms a clade with Ophichthus sp. 5, Ophichthus remiger, Ophichthus frontalis, Ophichthus sp. 6, and Ophichthus rex, suggesting that it would be the genetically closest congener.
The circular economy growth machine: A critical perspective on “post‐growth” and “pro‐growth” circularity approaches
Authors: Schultz Felix Carl , Pies Ingo 
Published: November 2023

AbstractThis forum article contributes to the prospering debate in the circular economy (CE) community discussing whether—and to what extent—the CE is reconcilable with economic growth. Within this discourse about a functional CE, there exist two contesting perspectives. One argues in favor of pro‐growth circularity, the other in favor of post‐growth circularity. The aim of this article is to develop a line of argumentation that helps in reconciliating the two seemingly antagonistic perspectives. Toward that end, this article applies the method of “practical syllogism” that is well known in moral philosophy, since it can enlighten how normative and positive arguments can be structured to enable the formulation of well‐justified moral conclusions. With the help of this interdisciplinary impulse, the article aims at detecting logical errors in current reasoning and fostering discursive learning processes. The ensuing arguments provide vital implications on the macro level by highlighting four critical elements to facilitate a CE transition, namely an intensive growth trajectory, an internalization of negative externalities through creating (missing) markets, an institutional encouragement of spreading positive externalities, and a diffusion of rents from innovation to society by taking the profit motive into service for enabling sustainability goals. Complementarily, the article provides implications on the micro level by highlighting the necessity to develop supplementary management competencies, namely governance competence to realize argumentative clarification and governance competence to (re‐)configurate institutional structures. This article may serve as an incubator to ease new ways of thinking into academia and practice.
Development of the arterial roots and ventricular outflow tracts
Authors: Anderson Robert H. , Lamers Wouter H. , Hikspoors Jill P. J. M. , Mohun Timothy J. , Bamforth Simon D. , Chaudhry Bill , Eley Lorraine , Kerwin Janet , Crosier Moira , Henderson Deborah J. 
Published: November 2023

AbstractThe separation of the outflow tract of the developing heart into the systemic and pulmonary arterial channels remains controversial and poorly understood. The definitive outflow tracts have three components. The developing outflow tract, in contrast, has usually been described in two parts. When the tract has exclusively myocardial walls, such bipartite description is justified, with an obvious dogleg bend separating proximal and distal components. With the addition of non‐myocardial walls distally, it becomes possible to recognise three parts. The middle part, which initially still has myocardial walls, contains within its lumen a pair of intercalated valvar swellings. The swellings interdigitate with the distal ends of major outflow cushions, formed by the remodelling of cardiac jelly, to form the primordiums of the arterial roots. The proximal parts of the major cushions, occupying the proximal part of the outflow tract, which also has myocardial walls, themselves fuse and muscularise. The myocardial shelf thus formed remodels to become the free‐standing subpulmonary infundibulum. Details of all these processes are currently lacking. In this account, we describe the anatomical changes seen during the overall remodelling. Our interpretations are based on the interrogation of serially sectioned histological and high‐resolution episcopic microscopy datasets prepared from developing human and mouse embryos, with some of the datasets processed and reconstructed to reveal the specific nature of the tissues contributing to the separation of the outflow channels. Our findings confirm that the tripartite postnatal arrangement can be correlated with the changes occurring during development.
Virtual reality used to distract children and young people with long‐term conditions from pain or pruritus: A scoping review using PAGER
Authors: Singleton Heidi , Mahato Preeti , Arden‐Close Emily , Thomas Sarah , Ersser Steven , Holley Debbie , Yang Xiaosong , Roberts Amanda 
Published: November 2023

AbstractAims and ObjectivesTo map out the primary research studies relating to how virtual reality (VR) has been used to distract children and young people with long‐term conditions from pain or pruritus.BackgroundPharmacologic treatment of chronic pain and pruritus may have side effects; hence, non‐invasive non‐pharmacological treatments are being sought.DesignThe scoping review followed the methodology recommended by the Joanna Briggs Institute, PAGER framework and PRISMA‐ScR checklist. The protocol was registered with the Open Science Registration on 14 February 2022 https//doi.org/10.17605/OSF.IO/K2R93.MethodsFive databases (Medline, CINAHL, PsycINFO, Web of Science and Scopus) were searched. Data were extracted from primary research studies published between 2000 and 2022 involving children and adolescent populations (<21 years) with a long‐term condition that had an element of enduring pruritus and/or pain.ResultsOf 464 abstracts screened, 35 full‐text papers were assessed with 5 studies meeting the eligibility criteria. Three main themes emerged from the included studies: (1) Improvements in pain and daily functioning; (2) positive perceptions of VR and (3) accessibility and feasibility of VR. No papers were found on the effect of VR on alleviating pruritus.ConclusionVR is feasible, acceptable, and safe for children and adolescents with chronic pain in a range of long‐term conditions and offers promise as an adjunctive treatment for improving chronic pain and quality of life. No studies were identified that targeted pruritis or measured pruritis outcomes; thus, the effects of VR for pruritis are unknown. There is a need for rigorously designed, randomised controlled trials to test the clinical and cost‐effectiveness of VR interventions for chronic pain and pruritis in children and adolescents. The use of the PAGER (Patterns, Advances, Gaps, Evidence for Practice and Research Recommendations) framework for scoping reviews helped to structure analysis and findings and identify research gaps.Relevance to Clinical PracticeVR interventions offer promise in improving chronic pain related to long‐term conditions.
The long‐run evolution of global real wages
Authors: de Zwart Pim 
Published: November 2023

AbstractThis article reviews the literature on comparative real wages in history that has emerged over the past two decades. Research has shown that unskilled men's real wages were higher in England and the Low Countries than in other parts of Europe and Asia from about 1720. Yet 18th‐ and 19th‐century real wages were even higher in the northern American colonies than they were in the European leaders, while those in Latin America were somewhere in the middle of the global wage ladder. This comparative picture is drawn on the basis of unskilled male day wages and various recent contributions focused on specific countries and time periods noting the variation in wage levels and trends for different groups of workers across urban and rural areas and labor contracts, varying days of labor per year, and the crucial and changing contributions of other family members. The latest research also highlights new ways to compute comparative cost‐of‐living indices. Building new datasets to take these issues into account in a new global comparative picture of long‐run real wages is a major area for future research.
Unobserved Worker Quality and Inter‐Industry Wage Differentials*
Authors: Ge Suqin , Macieira João 
Published: November 2023

AbstractThis study quantitatively assesses two alternative explanations for inter‐industry wage differentials: worker heterogeneity in the form of unobserved quality and firm heterogeneity in the form of a firm's willingness to pay (WTP) for workers' productive attributes. Building on hedonic models of differentiated product demand, we develop an empirical hedonic model of labor demand and apply a two‐stage nonparametric procedure to recover worker and firm heterogeneities. In the first stage we recover unmeasured worker quality by estimating market‐specific hedonic wage functions nonparametrically. In the second stage we infer each firm's WTP parameters for worker attributes by using first‐order conditions from the demand model. We apply our approach to quantify inter‐industry wage differentials on the basis of individual data from the NLSY79 and find that worker quality accounts for approximately two thirds of the inter‐industry wage differentials.
Do municipal unions improve cost efficiency for the social function? A quasi‐experimental endogenous stochastic frontier approach
Authors: Vidoli Francesco , Quintiliani Fabio , Ivaldi Giorgio , Marinuzzi Giorgia , Porcelli Francesco , Tortorella Walter 
Published: November 2023

AbstractHomogeneous national policies can generate heterogeneous effects on the territory. This paper aims to verify the impact of the entry of single Italian municipalities into an inter‐municipal association on the unitary costs of the social services supplied to the local communities. Panel cost stochastic frontier model in the presence of endogeneity has been introduced based on two pillars: a counterfactual setting to verify the aggregation effects concerning a set of similar municipalities and the use of a cost efficiency estimation methodology which considers the endogeneity of output with respect to cost. The results of our analysis show that the effects of adopting associated forms of service delivery can be very multifaceted and diversified according to the typology and the degree of implementation of the Municipal Union itself. The analysis sheds light on the effects of municipalities' organisational choices, addressing the consolidation of small municipalities not in binary terms but also—and above all—suggesting that it is the type of union that impacts the possibility of convergence towards greater cost efficiency.
Population Health Management Tools to Support School‐Based Oral Health Partnerships and Address Disparities
Authors: Zokaie Tooka , Valencia Alejandra , Kaste Linda M , Peters Karen 
Published: November 2023

ABSTRACTBACKGROUNDDental caries (cavities) experience is prevalent in US children, and national data show rates to be increasing among young children. Disparities are found for those in the low‐income and non‐Hispanic Black and Hispanic/Latinx groups. Use of caries prevention, specifically dental sealants, is low, even among school‐based programs.CONTRIBUTIONS TO THEORYA population health management (PHM) framework may support targeted school‐based case management to reduce oral health disparities. PHM‐oriented tools were applied to a school‐based oral health intervention and developed into a conceptual model. From 2014 to 2019, Chicago‐based Oral Health Forum (OHF) developed a case management intervention in schools, utilizing PHM tools. Through programmatic and school‐based partnerships, the PHM tools informed intervention to incorporate community‐based organizations, case management staffing, oral health education, targeted community outreach, and Community Dental Health Coordinators' training.CONCLUSIONSThrough a PHM framework, school‐based oral health partnerships targeting high‐need children was implemented. Use of PHM tools in school‐based health programs should be considered in other high caries schools.
First report of coffee leaf spot caused by Curvularia geniculata
Authors: Nam Hyo Song , Park Hyeon‐Seok , Kim Young Cheol 
Published: November 2023

AbstractDuring May and June 2021, the commercially grown coffee, variety SL34, grown commercially, developed necrotic, irregularly shaped spots on 1–5% of leaves. These plants were under greenhouse culture in the area of Goheung in South Korea (34°47′N, 127°46′E). The leaf spots, often observed at leaf margins, changed with time from reddish‐brown coloration to dark brown lesions with yellow halos. Morphological and molecular analysis confirmed the fungus from the lesions as Curvularia geniculata. The pathogenicity of the fungal isolate was verified by Koch's postulates on coffee plants grown under greenhouse conditions. These findings support that C. geniculata causes leaf spot disease in coffee plants and, to our knowledge, is the first time this disease has been reported in the world.
Locations of COVID‐19 vaccination provision: Urban‐rural differences
Authors: Ryan Grace W. , Kahl Amanda R. , Callaghan Don , Kintigh Bethany , Askelson Natoshia M. 
Published: November 2023

AbstractPurposeOur goal was to compare locations of COVID‐19 vaccine provision in urban and rural communities over the course of the pandemic.MethodsWe used the Iowa Immunization Registry Information System (IRIS) to identify the organizations providing COVID‐19 vaccines (eg, pharmacies, public health departments, and medical providers). Proportions of first‐dose vaccines by organization type and patient census‐based statistical area were generated. We calculated Chi‐square tests to assess differences among metropolitan, micropolitan, and noncore communities.FindingsIRIS data revealed that 64% (n = 2,043,251) of Iowans received their first COVID‐19 vaccine between December 14, 2020, and December 31, 2022. For metropolitan‐dwelling individuals, most first doses were administered at pharmacies (53%), with similar trends observed for micropolitan (49%) and noncore (42%) individuals. The second most common location for metropolitan individuals was medical practices (17%); public health clinics and departments were the second most common provider for micropolitan (26%) and noncore (33%) individuals. These trends shifted over time. In December 2020, hospitals were the most common vaccine provider for everyone, but by December 2022, medical providers were the most common source for metropolitan individuals, and pharmacies were most common for micropolitan and noncore individuals.ConclusionsTrends in the type of vaccine provider differentiated metropolitan residents from micropolitan and noncore residents. For the latter groups, local public health departments played a more significant role. Across all groups, pharmacists emerged as a critical vaccine provider. Our findings can be used to plan for seasonal vaccine campaigns as well as potential future mass vaccination campaigns.
Complexity of fungal polyketide biosynthesis and function
Authors: Stroe Maria C. , Gao Jia , Pitz Michael , Fischer Reinhard 
Published: November 2023

AbstractWhere does one draw the line between primary and secondary metabolism? The answer depends on the perspective. Microbial secondary metabolites (SMs) were at first believed not to be very important for the producers because they are dispensable for growth under laboratory conditions. However, such compounds become important in natural niches of the organisms, and some are of prime importance for humanity. Polyketides are an important group of SMs with aflatoxin as a well‐known and well‐characterized example. In Aspergillus spp., all 34 afl genes encoding the enzymes for aflatoxin biosynthesis are located in close vicinity on chromosome III in a so‐called gene cluster. This led to the assumption that most genes required for polyketide biosynthesis are organized in gene clusters. Recent research, however, revealed an enormous complexity of the biosynthesis of different polyketides, ranging from individual polyketide synthases to a gene cluster producing several compounds, or to several clusters with additional genes scattered in the genome for the production of one compound. Research of the last decade furthermore revealed a huge potential for SM biosynthesis hidden in fungal genomes, and methods were developed to wake up such sleeping genes. The analysis of organismic interactions starts to reveal some of the ecological functions of polyketides for the producing fungi.
Effect of surface ligands on the photoinduced electron transfer rate and efficiency in ZnO quantum dots and graphene oxide assemblies
Authors: Khalid Muhammad Adnan , Mubeen Muhammad , Mukhtar Maria , Sumreen Poshmal , Naz Bushra , Aydın Firdevs , Asil Demet , Iqbal Azhar 
Published: November 2023

AbstractApart from biocompatibility, ZnO quantum dots (QDs) are considered to be an efficient luminescence material due to their low cost and high redox potential. Here, we report the synthesis of ZnO QDs by using five different functionalizing ligands like mercaptoacetic acid (MAA), 3‐mercaptopropionic acid (MPA), octadecene (ODE), ethylene glycol (EG), and oleyl amine (OLA) and fabricate their assemblies with graphene oxide (GO). We investigate the role of functionalizing ligands as a surface modifier of ZnO QDs for their attachment to GO. The steady‐state photoluminescence (SSPL) and time‐resolved photoluminescence (TRPL) analyses demonstrate the photoluminescence (PL) quenching of ZnO QDs in ZnO QDs‐GO assembly. The highest reduction in PL intensity is observed with ZnO QDs‐GO assembly with EG as a surface functionalizing ligand. Cyclic voltammetry (CV) analysis confirms the feasibility of charge transfer from ZnO QDs to the GO. The maximum (79.43%) charge transfer efficiency (ECT) is observed in the case of ZnO‐MAA‐GO as compared to other assemblies. This means the thiol group‐containing ligands facilitate charge transfer as compared to hydroxyl and amine group ligands. This leads to the conclusion that charge transfer in ZnO QDs‐GO assemblies depends strongly on the nature of surface ligands.