bluuebunny/crossref_metadata_2025_split huggingface dataset:
STRATEGI PENCEGAHAN PERSELISIHAN HUBUNGAN INDUSTRIAL ANTARA PEKERJA/BURUH DAN PERUSAHAAN DI KOTA BALIKPAPAN PROVINSI KALIMANTAN TIMUR
Authors: Satyanagara AJisaka Bagas , Wahab Abdul 
Published: January 2024

Meningkatnya jumlah perusahaan dan pekerja di Kota Balikpapan berdampak pada kompleksitas hubungan industrial dan tingginya perselisihan. Eksistensi perselisihan hubungan industrial yang masih menyentuh angka yang cukup tinggi dengan keterbatasan tenaga mediator cukup menghambat proses mediasi dan pencegahan perselisihan yang terjadi. Penelitian ini bertujuan unutk menganalisis strategi Dinas Ketenagakerjan dalam pencegahan perseliisihan hubungan industrial dengan mengidentifikasi dan menganalisis faktor internal (kekuatan dan kelemahan) dan eksternal (peluang dan ancaman) dengan Analisis SWOT. Penelitian ini merupakan penelitian deskriptif kualitatif dengan pengumpulan data dengan teknik wawancara, observasi, dokumentasi, kuesioner SWOT dengan penganalisisan data dengan Analisis Matriks IE, Analisis Grand Strategy, Matriks SWOT serta analisis QSPM. Hasil penelitian berdasarkan analisis QSPM pada 3 tahapan analisis sebelumnya (Matriks IE, Grand Strategy dan Matriks SWOT) ditentukan bahwa strategi penetrasi pasar menjadi strategi yang paling sesuai daripada strategi pengembangan. Adapun, strategi yang dapat diterapkan pada penetrasi pasar Dinas Ketenagakerjaan adalah mempromosikan program-program terkait upaya pencegahan perselisihan hubungan industrial, mengajukan usulan terkait pemenuhan kebutuhan tenaga kerja mediator secara kuantitas maupun kualitas dan peningkatan kapasitas serikat pekerja dan pengusaha melalui penguatan kelembagaan dan sosialisasi.

Kata Kunci: Perselisihan Hubungan Industrial, Dinas Ketenagakerjaan, Strategi, SWOT
Development of a prediction system for precipitation- and wind-causing typhoons affecting the Korean peninsula using observational data
Authors: Kim Minyeong , Won Seonghee , Lee Hyunsoo 
Published: January 2024

Introduction: When the forecasted typhoon track differs from the numerical model’s prediction, the estimated precipitation and wind from the model may not be reliable. Typically, forecasters receive numerical model forecasts with a delay of 4 h or more in calculation time. However, a more timely reference of precipitation and wind forecasts is required in an emergency with an approaching typhoon. Analyses of the observational data of typhoon-related characteristics, such as heavy rainfall and strong winds, from 1997 to 2021 revealed that their distribution areas are considerably affected by typhoon tracks. In this study, we developed a precipitation and wind prediction system based on the observational data of the typhoons that affected the Korean Peninsula.Methods: Typhoon tracks were categorized into west-coast landfalls, southeast landfalls, and those passing the Korea Strait. Each category affects the Korean Peninsula differently in terms of rainfall and wind. We devised a system that predicts these patterns based on incoming typhoon tracks. We can make forecasts by comparing the approaching typhoons to previous instances and analyzing their center, movement direction, and size. Observations from these past typhoons were averaged to produce a forecast grid for each new typhoon.Results: Our system, validated from 2019 to 2022, showed a wind speed root-mean-square error of 3.37 m/s and a precipitation accuracy index of 0.72. For comparison, traditional numerical models yielded 5.04 m/s and 0.75, respectively. This indicates that our system is comparably efficient and computationally less demanding.Discussion: Our system’s strength is its ability to offer real-time typhoon forecasts, often faster than numerical models. However, its dependence on historical data limits its predictive power for atypical weather scenarios. It is essential to consider integrating ensemble models with these observations for enhanced accuracy. Since 2022, this system has been operational at the Korea Meteorological Administration, showing consistent reliability in forecasting.
Research on the dynamic characteristics of the electromagnetic repulsion mechanism of a self-driving fault current limiter
Authors: Song Rui , Ding Yujie , Wang Xuebin , Fu Guobin , Si Junjie , Wang Da , Chen Xiaoyue , Ai Shaogui 
Published: January 2024

A fault self-driven current limiter is proposed in the paper, which uses a special fault current direct-driven electromagnetic repulsion mechanism to realize the first half-wave of the fault current over the zero point into the current-limiting reactance. The paper analyzes the working principle of the self-driven electromagnetic repulsion mechanism, establishes the equivalent model of the mechanism, and simulates the dynamic characteristics of the electromagnetic repulsion mechanism through the calculation of the double-layer iterative algorithm in time and space. The LC oscillation loop test platform is built, and the stroke–time curve of the prototype is measured. In the test, the prototype is driven by a 3 kA current, and the first half-wave stroke (FHWS) is 3.55 mm past the zero point, which is consistent with the simulation and test results. The effects of structural parameters such as the radius, thickness, and number of turns of the self-driven electromagnetic repulsion mechanism on the dynamic characteristics of the electromagnetic repulsion mechanism are investigated, and it is found that the first half-wave stroke can be significantly improved by increasing the number of turns and outer diameter of the coil. The optimum height of the dynamic repulsion coil is approximately 3 mm.
Diagnostic value of cerebrospinal fluid human epididymis protein 4 for leptomeningeal metastasis in lung adenocarcinoma
Authors: Li Xiangyu , Chen Kun , Li Jie , Tang Xuemei , Ruan Haoyu , Guan Ming 
Published: January 2024

BackgroundThe diagnosis of lung adenocarcinoma (LUAD) leptomeningeal metastasis (LM) remains a clinical challenge. Human epididymis protein 4 (HE4) functions as a novel tumor biomarker for cancers. This study aimed to assess the diagnostic value of cerebrospinal fluid (CSF) HE4, and combined with CEACAM6, for LUAD LM.MethodsThe CSF HE4 protein level was measured in two independent cohorts by electrochemiluminescence. Test cohort included 58 LUAD LM patients, 22 LUAD patients without LM (Wiot-LM), and 68 normal controls. Validation cohort enrolled 50 LUAD LM patients and 40 normal controls, in parallel with Wiot-LM patients without brain metastases (19 Wiot-LM/BrM patients) or with BrM (26 BrM patients). The CSF level of CEA, CA125, CA153, CA199, CA724, NSE and ProGRP of these samples was measured by electrochemiluminescence, whereas the CSF CEACAM6 level was detected by enzyme-linked immunosorbent assay (ELISA). In addition, the serum level of these biomarkers was detected by same method as CSF.ResultsThe level of HE4 or CEACAM6 in CSF samples from LUAD LM patients was significantly higher than those from normal controls and Wiot-LM patients. The HE4 or CEACAM6 level in CSF was higher than that in serum of LM patient. The CSF HE4 or CEACAM6 level for distinguished LM from Wiot-LM showed good performance by receiver-operating characteristic analysis. The better discriminative power for LM was achieved when HE4 was combined with CEACAM6. In addition, the CSF HE4 and CEACAM6 level showed little or no difference between Wiot-LM/BrM and BrM patients, the BrM would not significantly influence the HE4 or CEACAM6 level in CSF. The diagnostic power of CSF CA125, CA153, CA199, CA724, NSE and ProGRP for LUAD LM were not ideal.ConclusionThe combination with HE4 and CEACAM6 has the promising application for the diagnosis of LUAD LM.
An efficient swarm intelligence approach to the optimization on high-dimensional solutions with cross-dimensional constraints, with applications in supply chain management
Authors: Liu Hsin-Ping , Phoa Frederick Kin Hing , Chen-Burger Yun-Heh , Lin Shau-Ping 
Published: January 2024

IntroductionThe Swarm Intelligence Based (SIB) method has widely been applied to efficient optimization in many fields with discrete solution domains. E-commerce raises the importance of designing suitable selling strategies, including channel- and direct sales, and the mix of them, but researchers in this field seldom employ advanced metaheuristic techniques in their optimization problem due to the complexities caused by the high-dimensional problems and cross-dimensional constraints.MethodIn this work, we introduce an extension of the SIB method that can simultaneously tackle these two challenges. To pursue faster computing, CPU parallelization techniques are employed for algorithm acceleration.ResultsThe performance of the SIB method is examined on the problems of designing selling schemes in different scales. It outperforms the Genetic Algorithm (GA) in terms of both the speed of convergence and the optimized capacity as measured using improvement multipliers.
CT−based radiomics signature for differentiating pyelocaliceal upper urinary tract urothelial carcinoma from infiltrative renal cell carcinoma
Authors: Zhai Xiaoli , Sun Penghui , Yu Xianbo , Wang Shuangkun , Li Xue , Sun Weiqian , Liu Xin , Tian Tian , Zhang Bowen 
Published: January 2024

ObjectivesTo develop a CT-based radiomics model and a combined model for preoperatively discriminating infiltrative renal cell carcinoma (RCC) and pyelocaliceal upper urinary tract urothelial carcinoma (UTUC), which invades the renal parenchyma.Materials and methodsEighty patients (37 pathologically proven infiltrative RCCs and 43 pathologically proven pyelocaliceal UTUCs) were retrospectively enrolled and randomly divided into a training set (n = 56) and a testing set (n = 24) at a ratio of 7:3. Traditional CT imaging characteristics in the portal venous phase were collected by two radiologists (SPH and ZXL, who have 4 and 30 years of experience in abdominal radiology, respectively). Patient demographics and traditional CT imaging characteristics were used to construct the clinical model. The radiomics score was calculated based on the radiomics features extracted from the portal venous CT images and the random forest (RF) algorithm to construct the radiomics model. The combined model was constructed using the radiomics score and significant clinical factors according to the multivariate logistic regression. The diagnostic efficacy of the models was evaluated using receiver operating characteristic (ROC) curve analysis and the area under the curve (AUC).ResultsThe RF score based on the eight validated features extracted from the portal venous CT images was used to build the radiomics model. Painless hematuria as an independent risk factor was used to build the clinical model. The combined model was constructed using the RF score and the selected clinical factor. Both the radiomics model and combined model showed higher efficacy in differentiating infiltrative RCC and pyelocaliceal UTUC in the training and testing cohorts with AUC values of 0.95 and 0.90, respectively, for the radiomics model and 0.99 and 0.90, respectively, for the combined model. The decision curves of the combined model as well as the radiomics model indicated an overall net benefit over the clinical model. Both the radiomics model and the combined model achieved a notable reduction in false-positive and false-negativerates, resulting in significantly higher accuracy compared to the visual assessments in both the training and testing cohorts.ConclusionThe radiomics model and combined model had the potential to accurately differentiate infiltrative RCC and pyelocaliceal UTUC, which invades the renal parenchyma, and provide a new potentially non-invasive method to guide surgery strategies.
Safety and effectiveness of CIMAvax-EGF administered in community polyclinics
Authors: Ortiz Carrodeguas Ramón A. , Lorenzo Monteagudo Geidy , Guerra Chaviano Pedro P. , Álvarez Montané Irene , Salomón Saldívar Eva E. , Lobaina Lambert Leonardo , Camacho Sosa Kirenia , Bermúdez Pino Raúl , Blanco Mustelier Poncio , Valdés Rodríguez Elba , González Piloto Shairis , Guerra de la Vega Arelys , Valdés Sánchez Lizet , Montes De Santis Arasay , Parra Zabala Jenelly , Viada González Carmen , Calvo Aguilera Nadia , Saavedra Hernández Danay , Santos Morales Orestes , Crombet Ramos Tania 
Published: January 2024

In spite of the advances in immunotherapy and targeted therapies, lung cancer continues to be the leading cause of cancer-related death. The epidermal growth factor receptor is an established target for non-small cell lung cancer (NSCLC), and its overactivation by the ligands can induce accelerated proliferation, angiogenesis, and metastasis as well as proinflammatory or immunosuppressive signals. CIMAvax-EGF is an epidermal growth factor (EGF)-depleting immunotherapy that is approved for the treatment of NSCLC patients in Cuba. The study was designed as a phase IV trial to characterize the safety and effectiveness of CIMAvax-EGF in advanced NSCLC patients treated in 119 community polyclinics and 24 hospitals. CIMAvax-EGF treatment consisted of four bi-weekly doses followed by monthly boosters. Overall, 741 NSCLC patients ineligible for further cancer-specific treatment were enrolled. CIMAvax-EGF was safe, and the most common adverse events consisted of mild-to-moderate injection site reactions, fever, chills, tremors, and headache. For patients completing the loading doses, the median survival was 9.9 months. For individuals achieving at least stable disease to the frontline and completing vaccination induction, the median survival was 12 months. Most of the functional activities and symptoms evaluated through the European Organisation for Research and Treatment of Cancer (EORTC) QLQ-C30 questionnaire improved over time. In conclusion, this real-world trial demonstrated that CIMAvax-EGF was safe and effective in patients who were vaccinated in the maintenance scenario. A larger effect was seen in subjects with poor prognosis like those with squamous tumors and high EGF levels. Remarkably, this community-based intervention was very important because it demonstrated the feasibility of treating advanced lung cancer patients with active immunotherapy in primary care institutions. In addition to CIMAvax-EGF, patients received supportive care at the community clinic. Vaccine administration by the family doctors at the polyclinics reduced the patients’ burden on the medical oncology services that continued providing chemotherapy and other complex therapies. We conclude that community polyclinics constitute the optimal scenario for administering those cancer vaccines that are safe and require prolonged maintenance in patients with advanced cancer, despite the continuous deterioration of their general condition.Clinical trial registrationhttps://rpcec.sld.cu/trials/RPCEC00000205-En, identifier RPCEC00000205.
Depletion of the m1A writer TRMT6/TRMT61A reduces proliferation and resistance against cellular stress in bladder cancer
Authors: Monshaugen Ida , Luna Luisa , Rhodes Jayden , Kristiansen Felicia Iselin Svensson , Lång Anna , Bøe Stig Ove , Dutta Anindya , Su Zhangli , Klungland Arne , Ougland Rune 
Published: January 2024

BackgroundBladder cancer (BLCA) is a common and deadly disease that results in a reduced quality of life for the patients and a significant economic burden on society. A better understanding of tumorigenesis is needed to improve clinical outcomes. Recent evidence places the RNA modification m1A and its regulatory proteins TRMT6/TRMT61A and ALKBH3 in BLCA pathogenesis.MethodsTRMT6/TRMT61A, ALKBH1, and ALKBH3 expression was examined in human BLCA cell lines and a normal urinary tract epithelium cell line through qRT-PCR and western blot analysis. Prestoblue Cell Viability Reagent, wound-healing assay, and live-cell imaging-based cell displacement analysis, were conducted to assess proliferation, migration, and displacement of this BLCA cell line panel. Cell survival was assessed after inducing cellular stress and activating the unfolded protein response (UPR) with tunicamycin. Moreover, siRNA-mediated gene silencing in two BLCA cell lines (5637 and HT1197) was conducted to investigate the biological roles of TRMT6/TRMT61A.ResultsHeterogeneous morphology, proliferation, displacement, tunicamycin sensitivity, and expression levels of m1A regulators were observed among the panel of cell lines examined. In general, TRMT61A expression was increased in BLCA cell lines when compared to SV-HUC-1. Depletion of TRMT6/TRMT61A reduced proliferation capacity in both 5637 and HT1197 cell lines. The average cell displacement of 5637 was also reduced upon TRMT6/TRMT61A depletion. Interestingly, TRMT6/TRMT61A depletion decreased mRNA expression of targets associated with the ATF6-branch of the UPR in 5637 but not in HT1197. Moreover, cell survival after induction of cellular stress was compromised after TRMT6/TRMT61A knockdown in 5637 but not in HT1197 cells.ConclusionThe findings suggest that TRMT6/TRMT61A plays an oncogenic role in BLCA and is involved in desensitizing BLCA cells against cellular stress. Further investigation into the regulation of TRMT6/TRMT61A expression and its impact on cellular stress tolerance may provide insights for future BLCA treatment.
Survival impact and safety of intrathoracic and abdominopelvic cytoreductive surgery in advanced ovarian cancer: a systematic review and meta-analysis
Authors: Wang Jiaxi , Wang Xingyu , Yin Wanjun , Zhang Shiqian 
Published: January 2024

PurposeAchieving no residual disease is essential for increasing overall survival (OS) and progression-free survival (PFS) in ovarian cancer patients. However, the survival benefit of achieving no residual disease during both intrathoracic and abdominopelvic cytoreductive surgery is still unclear. This meta-analysis aimed to assess the survival benefit and safety of intrathoracic and abdominopelvic cytoreductive surgery in advanced ovarian cancer patients.MethodsWe systematically searched for studies in online databases, including PubMed, Embase, and Web of Science. We used Q statistics and I-squared statistics to evaluate heterogeneity, sensitivity analysis to test the origin of heterogeneity, and Egger’s and Begg’s tests to evaluate publication bias.ResultsWe included 4 retrospective cohort studies, including 490 patients, for analysis; these studies were assessed as high-quality studies. The combined hazard ratio (HR) with 95% confidence interval (CI) for OS was 1.92 (95% CI 1.38-2.68), while the combined HR for PFS was 1.91 (95% CI 1.47-2.49). Only 19 patients in the four studies reported major complications, and 4 of these complications were surgery related.ConclusionThe maximal extent of cytoreduction in the intrathoracic and abdominopelvic tract improves survival outcomes, including OS and PFS, in advanced ovarian cancer patients with acceptable complications.Systematic Review RegistrationPROSPERO, identifier CRD42023468096
One-year follow-up of young people with ME/CFS following infectious mononucleosis by Epstein-Barr virus
Authors: Pricoco Rafael , Meidel Paulina , Hofberger Tim , Zietemann Hannah , Mueller Yvonne , Wiehler Katharina , Michel Kaja , Paulick Johannes , Leone Ariane , Haegele Matthias , Mayer-Huber Sandra , Gerrer Katrin , Mittelstrass Kirstin , Scheibenbogen Carmen , Renz-Polster Herbert , Mihatsch Lorenz , Behrends Uta 
Published: January 2024

BackgroundInfectious mononucleosis after primary infection with Epstein-Barr virus (EBV-IM) has been linked to the development of myalgic encephalomyelitis/chronic fatigue-syndrome (ME/CFS) in children, adolescents, and young adults. Here, we present clinical phenotypes and follow-up data from a first German cohort of young people with ME/CFS following EBV-IM.Methods12 adolescents and 13 young adults were diagnosed with IM-triggered ME/CFS at our specialized tertiary outpatient service by clinical criteria requiring post-exertional malaise (PEM) and a history of confirmed EBV primary infection as triggering event. Demographic information, laboratory findings, frequency and severity of symptoms, physical functioning, and health-related quality of life (HRQoL) were assessed and re-evaluated 6 and 12 months later.ResultsYoung adults displayed more severe symptoms as well as worsening of fatigue, physical and mental functioning, and HRQoL throughout the study, compared to adolescents. After one year, 6/12 (54%) adolescents no longer met the diagnostic criteria for ME/CFS while all young adults continued to fulfill the Canadian consensus criteria. Improvement in adolescents was evident in physical functioning, symptom frequency and severity, and HRQoL, while young adults showed little improvement. EBV serology and EBV DNA load did not correlate with distinct clinical features of ME/CFS, and clinical chemistry showed no evidence of inflammation. Remarkably, the median time from symptom onset to ME/CFS diagnosis was 13.8 (IQR: 9.1–34.9) months.ConclusionsME/CFS following EBV-IM is a severely debilitating disease often diagnosed late and with limited responses to conventional medical care, especially in adults. Although adolescents may have a better prognosis, their condition can fluctuate and significantly impact their HRQoL. Our data emphasize that biomarkers and effective therapeutic options are also urgently needed to improve medical care and pave the way to recovery.
Effect of calcium-channel blockers on the risk of active tuberculosis and mortality: systematic review and meta-analysis
Authors: Meregildo-Rodriguez Edinson Dante , Asmat-Rubio Martha Genara , Bardales-Zuta Victor Hugo , Vásquez-Tirado Gustavo Adolfo 
Published: January 2024

Introduction: Recent studies suggest that calcium channel blockers (CCBs) could reduce the risk of active tuberculosis and improve clinical outcomes. We aimed to synthesize the evidence regarding the effect of CCBs on the risk of developing active tuberculosis and mortality.Methods: We systematically searched for observational studies and clinical trials published in six databases until 31 August 2023, following a PECO/PICO strategy.Results: We included eight observational studies, 4,020,830 patients, among whom 241,761 had diabetes mellitus and 30,397 had active tuberculosis. According to our results, CCBs reduce the risk of developing active tuberculosis by 29% (RR 0.71; 95% CI 0.67–0.75) in patients with and without diabetes mellitus. However, CCBs do not show any benefit in terms of tuberculosis-related mortality (RR 1.00; 95% CI 0.98–1.02). For both outcomes, no statistical heterogeneity was found (I2 = 0, p &gt; 0.10). This protective effect of CCBs on the risk of active tuberculosis remained independent of the type of patient (with diabetes mellitus vs. general population) or the class of CCB administered (DHP-CCB vs. non-DHP-CCB) (test for subgroup differences I2 = 0, p &gt; 0.10). However, this beneficial effect was more significant among the general population (RR 0.70; 95% CI 0.66–0.74) compared to patients with diabetes mellitus (RR 0.72; 95% CI 0.61–0.86) and among those patients treated with DHP-CCBs (RR 0.69; 95% CI 0.63–0.74) compared to patients treated with non-DHP-CCBs (RR 0.72; 95% CI 0.67–0.78).Conclusion: CCBs may reduce the risk of active TB in patients with diabetes and the general population. On the contrary, CCBs do not seem to have a protective effect on tuberculosis-related mortality. However, more evidence is still needed. We recommend developing clinical trials to verify these findings, including more diverse populations.Systematic Review Registration: [https://www.crd.york.ac.uk/prospero/display_record.php?RecordID=352129]