bluuebunny/crossref_metadata_2025_split huggingface dataset:
Closing the gap while standing still: clinimetric properties of a low-cost balance platform and a user-friendly app for posturography
Authors: Vredeveld Tom , Stins John F. , van Vliet Annelies J. , Tuinder Vincent C.M. , Ramaekers Stephan P.J. , Coppieters Michel W. , Pool-Goudzwaard Annelies L. 
Published: February 2025

Background
The Wii Balance Board (WBB) is used as a rehabilitation tool for balance or strength interventions and posturography in balance tasks. Nonetheless, implementation of posturography using the WBB in a clinical setting is hampered by required technical skills for signal processing to obtain meaningful balance measures. Therefore, this study aims to evaluate the concurrent validity and test–retest reliability of a WBB to measure center of pressure (COP) parameters and to provide an easy-to-use web application to improve implementation of posturography in clinical practice.

Methods
A cross-sectional study was carried out including 30 healthy adults who performed repeated balance tasks including single and double leg standing still with eyes open or eyes closed. A WBB on top of a laboratory-grade force plate synchronously measured COP. Parameters based on COP displacement were calculated, including standard deviation of displacement, velocity, pathlength and 95% predicted ellipse area.

Results
The concurrent validity of the WBB to measure COP in quiet standing still tasks was excellent for all parameters (Intraclass Correlation Coefficient (ICC) > 0.900, p < 0.001), apart from medio-lateral velocity (ICC = 0.571, p = 0.090 to ICC = 0.711, p = 0.057). For the single leg balance tasks, across the two measurements, all WBB COP derived parameters showed excellent correlations with COP parameters derived from a laboratory-grade force plate (ICC > 0.95, p < 0.001). Test–retest reliability of the WBB was poor (ICC below 0.5) to occasionally good (ICC between 0.75 to 0.90) for the COP parameters from quiet standing balance tasks. Comparable reliability was found for the repeated measurements of single leg standing still. Power spectra analysis of both force plates revealed larger measurement error by the WBB in medio-lateral direction in tasks requiring minimal postural adjustments.

Conclusion
The WBB revealed excellent concurrent validity with a laboratory-grade force plate for balance tasks on a single leg or two legs for most COP parameters. The reliability was poor to moderate for most tasks, however comparable to the findings from the laboratory grade force plate. An open-source web application, employing R Shiny, was created to provide a tool to analyse COP parameters. Hereby, it was demonstrated that open-source scientific tools may help researchers to bridge the gap between scientific findings and clinical use of posturography.
Impact of Nano-Urea Application on Wheat Yield and Soil Properties: A Sustainable Approach to Nutrient Management
Authors: Kumar Maneesh , Rai Sada Nand 
Published: February 2025

A field experiment was conducted during the winter (rabi) season of 2022–23 at Dugurpur village Nuaon Block under On Farm Trial by Krishi Vigyan Kendra, Kaimur, to investigate the Impact of Nano-Urea Application on Wheat Yield and Soil Properties. The experiment was tested in a randomized block design with 2-nano-urea based treatment,viz. farmers practice (100% RDF), 50% of RDN & 100% PK + nano urea @4ml/lt. water (Single spray at 35 DAS), 50% of RDN & 100% PK + 2 sprays of Nano Urea at (35 DAS) and (60-65DAS) @ 4 ml/lt water. Results revealed that, yield attributes were significantly higher with 50% RDN& 100% PK along with nano urea. This treatment also resulted in 1.6 and 4.2% more grain yield with 100% RDF (33.14 q/ha).The effective tillers/m2 and number of grains/spike whichresulted in significantly higher grain yield. Thus, 50% RDN & 100% PK along with 50% of RDN & 100% PK + 2 sprays of Nano Urea at (35 DAS) and (60-65DAS) @ 4 ml/lt water are the more productive options for wheat-growingfarmers keeping view of the uprising cost and crisis of urea.
School Vaccine Coverage and Medical Exemption Uptake After the New York State Repeal of Nonmedical Vaccination Exemptions
Authors: Correira John W. , Kamstra Rhiannon , Zhu Nanqing , Doll Margaret K. 
Published: February 2024

ImportanceAlthough New York State (NYS) recently adopted legislation eliminating nonmedical vaccination exemption options from school-entry requirements, the implications of the law for school vaccine coverage and medical vaccine exemption uptake have not been examined.ObjectiveTo evaluate the implications of the repeal of school-entry nonmedical vaccination exemptions for vaccine coverage and medical exemption uptake at NYS schools outside of New York City (NYC).Design, Setting, and ParticipantsThis cohort study had an interrupted time-series design and used generalized estimating equation models to examine longitudinal school immunization compliance data from the 2012 to 2013 through 2021 to 2022 school years. The cohort comprised NYS public and nonpublic schools, excluding NYC schools, with any students enrolled in kindergarten to 12th grade. Eligible schools had enrollment and immunization data before and after the implementation of the Senate Bill 2994A legislation. Data analyses were conducted in July 2023.ExposureSenate Bill 2994A was passed in June 2019, eliminating school-entry nonmedical vaccination exemptions. Since compliance with the law was evaluated for most students during the next school year, the 2019 to 2020 school year was considered to be the law’s effective date.Main Outcomes and MeasuresThe primary outcomes were school vaccine coverage (defined as the percentage of students at each school who completed grade-appropriate requirements for all required vaccines) and medical exemption uptake (defined as the percentage of students at each school who received a medical exemption).ResultsAmong the 3821 eligible schools, 3632 (95.1%) were included in the analysis, representing 2794 (96.9% of eligible) public schools and 838 (89.2% of eligible) nonpublic schools. The implementation of Senate Bill 2994A was associated with absolute increases in mean vaccine coverage of 5.5% (95% CI, 4.5%-6.6%) among nonpublic schools and 0.9% (95% CI, 0.7%-1.1%) among public schools, with additional annual increases in vaccine coverage observed through the 2021 to 2022 school year. The law’s implementation was also associated with a 0.1% (95% CI, 0.0%-0.1%) mean absolute decrease in medical vaccination exemption uptake at both public and nonpublic schools, and small but significant mean annual decreases in medical vaccination exemptions (0.02%; 95% CI, 0.01%-0.03%) through the end of the study period.Conclusions and RelevanceResults of this cohort study suggested that repeal of school-entry nonmedical vaccination exemptions was associated with increased vaccine coverage at NYS schools outside of NYC. Coverage gains were not replaced by increases in medical vaccination exemptions.
Thiourea‐Cation Chelation Based Hydrogel and its Application as Antibacterial Dressing for the Repair of Diabetic Wound
Authors: Meng Weilin , Lin Ze , Cheng Xuan , Gou Shuangqian , Wang Rong , Bu Pengzhen , Li Yan , Mi Bobin , Yu Yongsheng , Feng Qian , Cai Kaiyong 
Published: February 2024

AbstractFor various chronic wounds, bacterial infection is one of the important reasons that hinder their healing. Ion‐crosslinked antibacterial hydrogel dressings based on Ag+, Cu2+ and Zn2+, have made progress in clinical application. However, the toxicity of released metal ions cannot be ignored. Therefore, how to ensure the antibacterial performance of hydrogel dressing while reducing the amount of metal ions is a major challenge for the fabrication of metal ion based antibacterial hydrogel. In this study, a general method is proposed to design cationic ion‐crosslinked hydrogel based on thiourea groups. Taking the hydrogel formed by mixing thiourea modified hyaluronic acid (H‐ANCSN) with Ag+ (HA‐NCSN/Ag+ hydrogel) as an example, the characteristics and application potential of this kind of hydrogel are thoroughly explored. Due to the strong cationic chelation characteristics of thiourea groups, HA‐NCSN/Ag+ hydrogel can gel at low Ag+ concentration and achieve long‐term slow release of Ag+ at stable concentration to balance the antibacterial and biocompatible properties. Moreover, this dynamic thiourea‐Ag+ crosslinking also endowed the hydrogel with the property of “gelation and encapsulation first, injection to cover wound when necessary”. Then, the mangiferin self‐assembled nanoparticles are loaded into HA‐NCSN/Ag+ hydrogel as the radical oxygen species scavenger.
Hierarchical Scaffold with Directional Microchannels Promotes Cell Ingrowth for Bone Regeneration
Authors: Cheng Yaling , Li Xing , Gu Peiyang , Mao Ruiqi , Zou Yaping , Tong Lei , Li Zhulian , Fan Yujiang , Zhang Xingdong , Liang Jie , Sun Yong 
Published: February 2024

AbstractBone regenerative scaffolds with a bionic natural bone hierarchical porous structure provide a suitable microenvironment for cell migration and proliferation. Here, a bionic scaffold (DP‐PLGA/HAp) with directional microchannels is prepared by combining 3D printing and directional freezing technology. The 3D printed framework provides structural support for new bone tissue growth, while the directional pore embedded in the scaffolds provides an express lane for cell migration and nutrition transport, facilitating cell growth and differentiation. The hierarchical porous scaffolds achieve rapid infiltration and adhesion of bone marrow mesenchymal stem cells (BMSCs) and improve the expression of osteogenesis‐related genes. The rabbit cranial defect experiment presents significant new bone formation, demonstrating that DP‐PLGA/HAp offers an effective means to guide cranial bone regeneration. The combination of 3D printing and directional freezing technology might be a promising strategy for developing bone regenerative biomaterials.
Thiolation‐Based Protein–Protein Hydrogels for Improved Wound Healing
Authors: Liu Xing , Guo Zhao , Wang Jie , Shen Wenting , Jia Zhenzhen , Jia Shuang , Li Limiao , Wang Jieqi , Wang Liping , Li Jiaqi , Sun Yinan , Chen Yufang , Zhang Min , Bai Jia , Wang Liyao , Li Xinyu 
Published: February 2024

AbstractThe limitations of protein‐based hydrogels, including their insufficient mechanical properties and restricted biological functions, arise from the highly specific functions of proteins as natural building blocks. A potential solution to overcome these shortcomings is the development of protein–protein hydrogels, which integrate structural and functional proteins. In this study, a protein–protein hydrogel formed by crosslinking bovine serum albumin (BSA) and a genetically engineered intrinsically disordered collagen‐like protein (CLP) through Ag─S bonding is introduced. The approach involves thiolating lysine residues of BSA and crosslinking CLP with Ag+ ions, utilizing thiolation of BSA and the free‐cysteines of CLP. The resulting protein–protein hydrogels exhibit exceptional properties, including notable plasticity, inherent self‐healing capabilities, and gel–sol transition in response to redox conditions. In comparison to standalone BSA hydrogels, these protein–protein hydrogels demonstrate enhanced cellular viability, and improved cellular migration. In vivo experiments provide conclusive evidence of accelerated wound healing, observed not only in murine models with streptozotocin (Step)‐induced diabetes but also in zebrafish models subjected to UV‐burn injuries. Detailed mechanistic insights, combined with assessments of proinflammatory cytokines and the expression of epidermal differentiation‐related proteins, robustly validate the protein–protein hydrogel's effectiveness in promoting wound repair.
Ultrathin, Transferred Layers of Silicon Oxynitrides as Tunable Biofluid Barriers for Bioresorbable Electronic Systems
Authors: Hu Ziying , Zhao Jie , Guo Hexia , Li Rui , Wu Mingzheng , Shen Jiahong , Wang Yue , Qiao Zheng , Xu Yue , Haugstad Greg , An Dongqi , Xie Zhaoqian , Kandela Irawati , Nandoliya Khizar R. , Chen Yu , Yu Yi , Yuan Qunyao , Hou Junyu , Deng Yujun , AlDubayan Abdulaziz H. , Yang Quansan , Zeng Liangsong , Lu Di , Koo Jahyun , Bai Wubin , Song Enming , Yao Shenglian , Wolverton Chris , Huang Yonggang , Rogers John A. 
Published: February 2024

AbstractBio/ecoresorbable electronic systems create unique opportunities in implantable medical devices that serve a need over a finite time period and then disappear naturally to eliminate the need for extraction surgeries. A critical challenge in the development of this type of technology is in materials that can serve as thin, stable barriers to surrounding ground water or biofluids, yet ultimately dissolve completely to benign end products. This paper describes a class of inorganic material (silicon oxynitride, SiON) that can be formed in thin films by plasma‐enhanced chemical vapor deposition for this purpose. In vitro studies suggest that SiON and its dissolution products are biocompatible, indicating the potential for its use in implantable devices. A facile process to fabricate flexible, wafer‐scale multilayer films bypasses limitations associated with the mechanical fragility of inorganic thin films. Systematic computational, analytical, and experimental studies highlight the essential materials aspects. Demonstrations in wireless light‐emitting diodes both in vitro and in vivo illustrate the practical use of these materials strategies. The ability to select degradation rates and water permeability through fine tuning of chemical compositions and thicknesses provides the opportunity to obtain a range of functional lifetimes to meet different application requirements.
Isomerization of Benzothiadiazole Yields a Promising Polymer Donor and Organic Solar Cells with Efficiency of 19.0%
Authors: Lin Tao , Hai Yulong , Luo Yongmin , Feng Lingwei , Jia Tao , Wu Jiaying , Ma Ruijie , Dela Peña Top Archie , Li Yao , Xing Zengshan , Li Mingjie , Wang Min , Xiao Biao , Wong Kam Sing , Liu Shengjian , Li Gang 
Published: February 2024

AbstractThe exploration of high‐performance and low‐cost wide‐bandgap polymer donors remains critical to achieve high‐efficiency nonfullerene organic solar cells (OSCs) beyond current thresholds. Herein, the 1,2,3‐benzothiadiazole (iBT), which is an isomer of 2,1,3‐benzothiadiazole (BT), is used to design wide‐bandgap polymer donor PiBT. The PiBT‐based solar cells reach efficiency of 19.0%, which is one of the highest efficiencies in binary OSCs. Systemic studies show that isomerization of BT to iBT can finely regulate the polymers’ photoelectric properties including i) increasing the extinction coefficient and photon harvest, ii) downshifting the highest occupied molecular orbital energy levels, iii) improving the coplanarity of polymer backbones, iv) offering good thermodynamic miscibility with acceptors. Consequently, the PiBT:Y6 bulk heterojunction (BHJ) device simultaneously reaches advantageous nanoscale morphology, efficient exciton generation and dissociation, fast charge transportation, and suppressed charge recombination, leading to larger VOC of 0.87 V, higher JSC of 28.2 mA cm−2, greater fill factor of 77.3%, and thus higher efficiency of 19.0%, while the analog‐PBT‐based OSCs reach efficiency of only 12.9%. Moreover, the key intermediate iBT can be easily afforded from industry chemicals via two‐step procedure. Overall, this contribution highlights that iBT is a promising motif for designing high‐performance polymer donors.
Exploring and Engineering 2D Transition Metal Dichalcogenides toward Ultimate SERS Performance
Authors: Tang Xiao , Hao Qi , Hou Xiangyu , Lan Leilei , Li Mingze , Yao Lei , Zhao Xing , Ni Zhenhua , Fan Xingce , Qiu Teng 
Published: February 2024

AbstractSurface‐enhanced Raman spectroscopy (SERS) is an ultrasensitive surface analysis technique that is widely used in chemical sensing, bioanalysis, and environmental monitoring. The design of the SERS substrates is crucial for obtaining high‐quality SERS signals. Recently, 2D transition metal dichalcogenides (2D TMDs) have emerged as high‐performance SERS substrates due to their superior stability, ease of fabrication, biocompatibility, controllable doping, and tunable bandgaps and excitons. In this review, a systematic overview of the latest advancements in 2D TMDs SERS substrates is provided. This review comprehensively summarizes the candidate 2D TMDs SERS materials, elucidates their working principles for SERS, explores the strategies to optimize their SERS performance, and highlights their practical applications. Particularly delved into are the material engineering strategies, including defect engineering, alloy engineering, thickness engineering, and heterojunction engineering. Additionally, the challenges and future prospects associated with the development of 2D TMDs SERS substrates are discussed, outlining potential directions that may lead to significant breakthroughs in practical applications.
Analytical modeling of particle size effect on impact wear deformation characteristics of ductile materials
Authors: Cao Xuewen , Chen Junwen , Zang Xuerui , Feng Jiaxin , Peng Wenshan , Sun Xiaoyang , Hou Jian , Bian Jiang 
Published: February 2024

AbstractThis study aims to analytically predict the material impact wear rate and improve the prediction accuracy and applicability of existing impact wear prediction models. The ABAQUS software was used to numerically model and analyze the erosion pit morphology and stress distribution characteristics. Micromorphological testing was used to investigate the impact wear damage mechanism, and an improved impact wear prediction model was developed by introducing the particle size. The results show that the maximum von Mises stress in the impact area of the target material can reflect the severity of the damage to the target material. The peak stress varies with the impact angle. The target material significantly absorbs the energy of small particles at higher impact angles and large particles at vertical impacts. The depth of the hardened layer resulting from particle impact increases from 3 to 10 μm with increasing impact angle. When the impact angle is unchanged, the depth of the hardened layer increases by 3% to 5% with an increase in particle size. The hardened layer limits further plastic deformation of the metal material. Comparing the analysis results with the experimental results reveals that the proposed formula that uses the size factor can predict the volume loss of plastic metallic materials with different particle sizes, impact angles, and impact velocities more accurately.
Development and evaluation of 2,4‐disubstituted‐5‐aryl pyrimidine derivatives as antibacterial agents
Authors: Khalifa Hend , Rasheed Sari , Haupenthal Jörg , Herrmann Jennifer , Mandour Yasmine M. , Abadi Ashraf H. , Engel Matthias , Müller Rolf , Hirsch Anna K. H. , Abdel‐Halim Mohammad , Hamed Mostafa M. 
Published: February 2024

AbstractDesigning novel candidates as potential antibacterial scaffolds has become crucial due to the lack of new antibiotics entering the market and the persistent rise in multidrug resistance. Here, we describe a new class of potent antibacterial agents based on a 5‐aryl‐N2,N4‐dibutylpyrimidine‐2,4‐diamine scaffold. Structural optimization focused on the 5‐aryl moiety and the bioisosteric replacement of the side chain linker atom. Screening of the synthesized compounds focused on a panel of bacterial strains, including gram‐positive Staphylococcus aureus strains (Newman MSSA, methicillin‐ and vancomycin‐resistant), and the gram‐negative Escherichia coli (ΔAcrB strain). Several compounds showed broad‐spectrum antibacterial activity with compound 12, bearing a 4‐chlorophenyl substituent, being the most potent among this series of compounds. This frontrunner compound revealed a minimum inhibitory concentration (MIC) value of 1 µg/mL against the S. aureus strain (Mu50 methicillin‐resistant S. aureus/vancomycin‐intermediate S. aureus) and an MIC of 2 µg/mL against other tested strains. The most potent derivatives were further tested against a wider panel of bacteria and evaluated for their cytotoxicity, revealing further potent activities toward Streptococcus pneumoniae, Enterococcus faecium, and Enterococcus faecalis. To explore the mode of action, compound 12 was tested in a macromolecule inhibition assay. The obtained data were supported by the safety profile of compound 12, which possessed an IC50 of 12.3 µg/mL against HepG2 cells. The current results hold good potential for a new class of extended‐spectrum antibacterial agents.
Response Surface Optimization of Polysaccharides from Jaboticaba (Myrciaria cauliflora [Mart.] O.Berg) Fruits: Ultrasound‐Assisted Extraction, Structure Properties, and Antioxidant/Hypoglycemic Activities
Authors: Zhang Shaojie , Zhang Qian , Wang Tanggan , Li Chong , Tang Liqun , Xiao Leyi 
Published: February 2024

AbstractUltrasound‐assisted extraction (UAE) method proves to be more effective compared to traditional extraction methods. In the present study, response surface methodology (RSM) was used to determine the optimal process parameters for extracting polysaccharides (U‐MCP) from jaboticaba fruit using UAE. The optimum extraction conditions were ultrasonic time 70 min, extraction temperature 60 °C, and power 350 W. Under these conditions, the sugar content of U‐MCP was 52.8 %. The molecular weights of the ultrasound‐assisted extracted U‐MCP ranged from 9.52×102 to 3.27×103 Da, and consisted of five monosaccharides including mannose, galacturonic acid, glucose, galactose, and arabinose. Moreover, in vitro antioxidant and hypoglycaemic assay revealed that U‐MCP has prominent anti‐oxidant activities (1,1‐diphenyl‐2‐picryl‐hydrazyl (DPPH) radicals, hydroxyl radicals and 2,2′‐Azinobis (3‐ethylbenzothiazoline‐6‐sulfonic Acid Ammonium Salt) (ABTS) radicals scavenging activities) and hypoglycemic activities (α‐amylase and α‐glucosidase inhibition activities).
The clinical and genetic characteristics of maternally inherited diabetes and deafness (MIDD) with mitochondrial m.3243A > G mutation: A 10‐year follow‐up observation study and literature review
Authors: Zheng Shasha , Wang Juanjuan , Sun Minxian , Wang Pei , Shi Wei , Zhang Zhongzhi , Wang Zhongjing , Zhang Hongmei 
Published: February 2024

Key Clinical MessageMaternally inherited diabetes and deafness (MIDD) is often caused by the m.3243A > G mutation in mitochondrial DNA. Unfortunately, the characteristics of MIDD, especially long‐term outcomes and heteroplasmic changes, have not been well described previously. The purpose of this study was to describe the clinical and genetic features of a family with MIDD after 10 years of follow‐up.A 33‐year‐old male patient with typical characteristics of MIDD, including early‐onset diabetes, deafness, and low body mass index, was admitted to our department. Further investigation revealed that the vast majority of his maternal relatives suffered from diabetes with or without deafness. A detailed family history was then requested from the patient and a pedigree was constructed. The patient suspected of MIDD was screened for mutations using whole mitochondrial DNA sequencing. Candidate pathogenic variants were then validated in other family members through Sanger sequencing. The patient was diagnosed with MIDD, with inherited m.3243A > G mutation in the mitochondrially encoded tRNA leucine 1 (MT‐TL1) gene, after 10 years of symptom onset. The patient was then treated with insulin and coenzyme Q10 to improve mitochondrial function. During the follow‐up period, his fasting blood glucose and HbA1c levels were improved and the incidence of diabetic ketoacidosis was significantly reduced. Our findings indicate that whole mitochondrial DNA sequencing should be considered for patients suspected of MIDD to improve the efficiency of diagnosis and prognosis.