bluuebunny/crossref_metadata_2025_split huggingface dataset:
A multi‐layer thermo‐mechanical coupling hysteretic model for high damping rubber bearings at low temperature
Authors: Shen Jie , Akira Igarashi , Dang Ji , Hamada Yuki , Himeno Takehiko 
Published: December 2023

AbstractHigh damping rubber (HDR) bearings have been widely applied in seismic isolation of structures. However, the complex behavior of HDR bearings is influenced by thermal mechanism coupled with the seismic response of the structure, particularly at low ambient temperatures. In order to express the hysteretic restoring force behavior of HDR bearings involving temperature dependence, heating effect, and heat transfer with an improved accuracy, a multi‐layer thermo‐mechanical coupling model was developed. The thermal mechanism was illustrated by considering the heating effect and heat transfer in the multi‐layer thermal‐coupled model. A nonlinear hysteretic model including the temperature dependence of the stress‐strain relationship of rubber was incorporated. Quasi‐static cyclic loading was conducted for parameter identification and real‐time hybrid simulation tests were carried out for model validation. The model accurately represented the time‐dependent thermal mechanism within the bearing, considering the non‐uniform distribution of internal temperature. Numerical results exhibited good agreement with the experimental results, including the hysteresis curve, temperature history, and temperature distribution. The model demonstrated improved accuracy in computing the hysteretic behavior compared with an existing simple model.
Hybrid‐simulation‐based model calibration method for nonlinear seismic analysis
Authors: Zhang Hongzhou , Kwon Oh‐Sung , Christopoulos Constantin 
Published: December 2023

AbstractThe calibration of parameters of hysteretic models that simulate the hysteretic behavior of key structural components is a crucial task in the nonlinear seismic analysis of structures to ensure accurate analysis results. For complicated systems, a direct calibration of model parameters at the system level is almost impossible due to the lack of test data. Consequently, the calibration is usually conducted using test results with lower levels of complexity. Currently, a widely accepted practice in calibrating hysteretic model parameters in structural models is to utilize standardized cyclic tests of a single component. However, due to the simplified and unrealistic loading profile of standardized cyclic tests, the relevance between the calibration and the system‐level prediction capabilities can be weak. In other words, a well‐tuned hysteretic model that matches the standardized cyclic test results very well may not be able to produce the same level of accuracy in estimating the system‐level structural dynamic response where the calibrated components will experience more random and complicated loadings. In this paper, a method is proposed to calibrate hysteretic models in a test method with more realistic loading histories through hybrid simulations. The proposed calibration method is then validated by conducting a large number of hybrid simulations on a type of small‐scale buckling‐restrained brace (BRB) specimen. A framework is also proposed to evaluate the relevance between the calibration and the system‐level response considering uncertainties in hysteretic model parameters. The results demonstrate the superiority of the hybrid‐simulation‐based calibration method over the conventional cyclic‐test‐based calibration method.
MALL‐based collaborative writing in second language classroom: A systematic review
Authors: Wang Lisha 
Published: December 2023

AbstractDriven by the affordances and benefits of mobile technology, collaborative writing (CW) supported by mobile technologies has been increasingly implemented in the second language (L2) acquisition context. To shed light on the research foci and provide guidance for future research in this promising area, the present study conducted an in‐depth and systematic review of 25 empirical articles on CW supported by mobile technologies in the L2 context published from 2014 to 2022, including quantitative, qualitative, and mix‐methods research. A holistic analysis of these articles was conducted, covering various aspects such as research themes, research contexts and technology, theoretical/pedagogical frameworks, writing tasks, and instruments. Based on the analysis of the previous research, this study provided pedagogical suggestions concerning writing tasks, group division, participant training, and writing assessment and also explores future research directions.
Exploring the serotonin‐probiotics‐gut health axis: A review of current evidence and potential mechanisms
Authors: Akram Noor , Faisal Zargham , Irfan Rushba , Shah Yasir Abbas , Batool Syeda Ayesha , Zahid Toobaa , Zulfiqar Aqsa , Fatima Areeja , Jahan Qudsia , Tariq Hira , Saeed Farhan , Ahmed Aftab , Asghar Aasma , Ateeq Huda , Afzaal Muhammad , Khan Mahbubur Rahman 
Published: December 2023

AbstractModulatory effects of serotonin (5‐Hydroxytryptamine [5‐HT]) have been seen in hepatic, neurological/psychiatric, and gastrointestinal (GI) disorders. Probiotics are live microorganisms that confer health benefits to their host. Recent research has suggested that probiotics can promote serotonin signaling, a crucial pathway in the regulation of mood, cognition, and other physiological processes. Reviewing the literature, we find that peripheral serotonin increases nutrient uptake and storage, regulates the composition of the gut microbiota, and is involved in mediating neuronal disorders. This review explores the mechanisms underlying the probiotic‐mediated increase in serotonin signaling, highlighting the role of gut microbiota in the regulation of serotonin production and the modulation of neurotransmitter receptors. Additionally, this review discusses the potential clinical implications of probiotics as a therapeutic strategy for disorders associated with altered serotonin signaling, such as GI and neurological disorders. Overall, this review demonstrates the potential of probiotics as a promising avenue for the treatment of serotonin‐related disorders and signaling of serotonin.
Utilization of pomegranate and black grape seed by‐products in yogurt production: Effects on phenolic compounds and antioxidant activity
Authors: Çalişkanlar Sibel , Saygili Derya , Karagözlü Nural , Karagözlü Cem 
Published: December 2023

AbstractThe present study investigated the potential utilization of pomegranate and black grape seed by‐products of the food industry in yogurt production. Specifically, we examined the effect of polyphenols on antioxidants in yogurts produced using two different starter cultures: classical yogurt culture (Lactobacillus delbrueckii subsp. bulgaricus + Streptococcus thermophilus) and yogurt culture supplemented with L. casei. Various parameters, including pH, acidity, viscosity, fat content, protein content, dry matter content, color, microbiological properties, and sensory attributes, were analyzed in the yogurt products. The present findings indicate that incorporating pomegranate and grape seed powder and using different starter cultures significantly affected the yogurt's phenolic content and antioxidant activity. Furthermore, we observed decreased phenolic content and antioxidant activity during the 21‐day storage period. Interestingly, yogurts produced with pomegranate seed powder and L. casei culture exhibited higher antioxidant activity than the other samples. Importantly, none of the yogurts containing pomegranate and grape seed powders had microbial counts below 107 cfu/g for L. delbrueckii subsp. bulgaricus, S. thermophilus, and L. casei, indicating no adverse effects on probiotic properties. Sensory evaluation revealed that the yogurt product prepared with grape seed powder and a combination of yogurt culture (L. delbrueckii subsp. bulgaricus + Streptococcus thermophilus) and L. casei was particularly well‐received. In conclusion, the functional properties of grape seed powder and pomegranate seed powder make them suitable natural ingredients for enhancing the antioxidant activity of yogurt. The study highlights the potential of utilizing these by‐products to develop yogurt products with added health benefits.
Ultra‐high combined positive score and high serum albumin are favorable prognostic biomarkers for immune checkpoint inhibitors in head and neck squamous cell carcinoma
Authors: Saito Yuki , Kobayashi Kenya , Fukuoka Osamu , Sakai Toshihiko , Yamamura Koji , Ando Mizuo , Kondo Kenji 
Published: December 2023

AbstractBackgroundBiomarkers that predict response to immune checkpoint inhibitor (ICI) in recurrent metastatic squamous cell carcinoma of the head and neck (RMHNSCC) are not well known.MethodsWe prospectively measured the combined positive score (CPS) and administered ICI to patients with RMHNSCC.ResultsOf 51 patients, 23 patients had a CPS <20 and 12 patients (23.5%) had a CPS ≥90. CPS showed a negative correlation with serum albumin. Survival analysis showed a 2‐year survival rate of 24.1%. In multivariate analysis, CPS ≥90 (HR 0.3026, p = 0.02614) and albumin >3.5 (HR 0.3463, p = 0.01354) were the significant factors and plus chemotherapy (HR 0.4648, p = 0.07632) was not significant. Seven patients (14%) with CPS ≥90 and albumin >3.5 showed a 2‐year survival rate of 66. 7%.ConclusionsCPS ≥90 and albumin >3.5 cases are a subgroup of RMHNSCC that respond extremely well to ICI.
Low‐dose radiation therapy mobilizes antitumor immunity: New findings and future perspectives
Authors: Zhou Laiyan , Liu Yuanxin , Wu Yuanjun , Yang Xue , Spring Kong Feng‐Ming , Lu You , Xue Jianxin 
Published: December 2023

AbstractRadiotherapy has unique immunostimulatory and immunosuppressive effects. Although high‐dose radiotherapy has been found to have systemic antitumor effects, clinically significant abscopal effects were uncommon on the basis of irradiating single lesion. Low‐dose radiation therapy (LDRT) emerges as a novel approach to enhance the antitumor immune response due to its role as a leverage to reshape the tumor immune microenvironment (TIME). In this article, from bench to bedside, we reviewed the possible immunomodulatory role of LDRT on TIME and systemic tumor immune environment, and outlined preclinical evidence and clinical application. We also discussed the current challenges when LDRT is used as a combination therapy, including the optimal dose, fraction, frequency, and combination of drugs. The advantage of low toxicity makes LDRT potential to be applied in multiple lesions to amplify antitumor immune response in polymetastatic disease, and its intersection with other disciplines might also make it a direction for radiotherapy‐combined modalities.
Ex vivo tissue modelling informs drug selection for rare cancers
Authors: Lee Jenny H. , Ming Zizhen , Cheung Veronica K. Y. , Pedersen Bernadette , Wykes James J. , Palme Carsten E. , Clark Jonathan J. , Gupta Ruta , Rizos Helen 
Published: December 2023

AbstractThe identification and therapeutic targeting of actionable gene mutations across many cancer types has resulted in improved response rates in a minority of patients. The identification of actionable mutations is usually not sufficient to ensure complete nor durable responses, and in rare cancers, where no therapeutic standard of care exists, precision medicine indications are often based on pan‐cancer data. The inclusion of functional data, however, can provide evidence of oncogene dependence and guide treatment selection based on tumour genetic data. We applied an ex vivo cancer explant modelling approach, that can be embedded in routine clinical care and allows for pathological review within 10 days of tissue collection. We now report that ex vivo tissue modelling provided accurate longitudinal response data in a patient with BRAFV600E‐mutant papillary thyroid tumour with squamous differentiation. The ex vivo model guided treatment selection for this patient and confirmed treatment resistance when the patient's disease progressed after 8 months of treatment.
Chinese expert consensus statement on the clinical application of AFP/AFP‐L3%/DCP using GALAD and GALAD‐like algorithm in HCC
Authors: Huang Chenjun , Xiao Xiao , Zhou Lin , Chen Fuxiang , Wang Jianyi , Hu Xiaobo , Gao Chunfang ,   Clinical Laboratory Society of Chinese Rehabilitation Medicine Association, Molecular Diagnostics Society of Shanghai Medical Association, Tumor Immunology Branch of Shanghai Society for Immunology
Published: December 2023

AbstractBackgroundPrimary hepatocellular carcinoma (HCC) is one of the most prevalent world‐wide malignancies. Half of the newly developed HCC occurs in China. Optimizing the strategies for high‐risk surveillance and early diagnosis are pivotal for improving 5‐year survival. Constructing the scientific non‐invasive detection technologies feasible for medical and healthcare institutions is among the key routes for elevating the efficacies of HCC identification and follow‐up.ResultsBased on the Chinese and international guidelines, expert consensus statements, literatures and evidence‐based clinical practice experiences, this consensus statement puts forward the clinical implications, application subjects, detection techniques and results interpretations of the triple‐biomarker (AFP, AFP‐L3%, DCP) based GALAD, GALAD like models for liver cancer.ConclusionsThe compile of this consensus statement aims to address and push the reasonable application of the triple‐biomarker (AFP, AFP‐L3%, DCP) detections thus to maximize the clinical benefits and help improving the high risk surveillance, early diagnosis and prognosis of HCC.
Diagnostic accuracy of Point Of Care UltraSound (POCUS) in clinical practice: A retrospective, emergency department based study
Authors: Spampinato Michele Domenico , Luppi Francesco , Cristofaro Enrico , Benedetto Marcello , Cianci Antonella , Bachechi Tommaso , Ghirardi Caterina , Perna Benedetta , Guarino Matteo , Passaro Angelina , De Giorgio Roberto , Sofia Soccorsa 
Published: December 2023

AbstractAimsPoint‐of‐care ultrasound (POCUS) is the acquisition and interpretation of ultrasound imaging at the bedside to solve specific clinical questions based on signs and symptoms of presentation. While several studies evaluated POCUS diagnostic accuracy for a variety of clinical pictures in the emergency department (ED), only a few data are available on POCUS diagnostic accuracy performed by physicians with different POCUS skills. The objective of this research was to evaluate the diagnostic accuracy of POCUS compared to standard diagnostic imaging in the ED.Materials and MethodsThis was a retrospective study conducted in the ED of a third‐level university hospital. Patients who underwent cardiac, thoracic, abdominal, or venous lower limb POCUS and a standard imaging examination between June 2021 and January 2022 were included.Results1047 patients were screened, and 844 patients included. A total of 933 POCUS was included (102, 12.09%, cardiac; 466, 55.21%, thoracic; 336, 39.8%, abdominal; 29, 3.44%, lower limb venous POCUS), accounting for 2029 examinations. POCUS demonstrated 96.6% (95% CI 95.72–97.34) accuracy, 47.73 (95% CI 33.64–67.72) +LR, 0.09 (95% CI 0.06–0.12) −LR. +LR was greater than 10 for all investigations but for hydronephrosis (5.8), and −LR never exceeded 0.4.ConclusionsPOCUS exhibited high diagnostic accuracy for virtually all conditions when performed by emergency department physicians.
Identification and exploration of aging‐related subtypes and distinctive role of SERPINE1 in heart failure based on single‐cell and bulk RNA sequencing data
Authors: Li Shengnan , Kong Fanliang , Xu Xuan , Song Sifan , Wu Yandan , Tong Jiayi 
Published: December 2023

AbstractAging is a major risk factor for heart failure (HF) and is the leading cause of death worldwide. Currently, the nature of the relationship between aging and HF is not entirely clear. Herein, this study aimed to explore new diagnostic biomarkers, molecular typing and therapeutic strategies for HF by investigating the biological significance of aging‐related genes in HF. A total of 157 differentially expressed genes (DEGs) were screened totally between HF and normal samples, and functional enrichment analysis of DEGs revealed the strong association of HF progression with aging, immune processes and metabolism. Six HF‐specific aging‐related genes were further identified, and a diagnostic model was developed and validated for good diagnostic efficacy. In addition, we collected blood samples from 10 normal controls and 10 HF patients for RT‐qPCR analysis to verify the bioinformation. We also identified two aging‐associated subtypes with distinctly different immune infiltration and metabolic microenvironment. Further single‐cell sequencing analysis conducted in the study identified SERPINE1 as a key gene in HF. The distinctive role of SERPINE1 fibroblasts was revealed, including three main findings: (I) fibroblasts had a higher proportion and expression of SERPINE1 levels in HF; (II) the ligand–receptor pair MDK‐LRP1 made the most contributions in high interactions with other cell types in SERPINE1 fibroblasts; and (III) SERPINE1 fibroblasts were associated with the interaction of extracellular matrix and receptor and may be regulated by the transcription factor EGR1. In conclusion, this study highlights the importance of aging‐related genes in diagnosing HF and regulating immune infiltration. We also identified different HF subtypes and a potentially crucial gene, which may provide a better understanding of the molecular‐level mechanisms of aging‐related HF and aid in developing effective therapeutic strategies.
A data‐informed timeline for hospital discharge with a reasonably low risk of unplanned readmission after open and minimally invasive liver resections
Authors: Kawaguchi Yoshikuni , Ito Kyoji , Hayakawa Tomoaki , Hayashi Yoshihito , Fukuda Kaito , Abe Satoru , Ichida Akihiko , Akamatsu Nobuhisa , Kaneko Junichi , Hasegawa Kiyoshi 
Published: December 2023

AbstractBackgroundPostoperative complications following liver resection remain high, ranging from 20% to 50%. Patients are hospitalized for a certain period of time following liver resection because of the risk of postoperative complications. We hypothesized that the risk of complications decreases with each complication‐free postoperative day after open and minimally invasive liver resections and can be stratified using a recently reported three‐level complexity classification.MethodsPatients undergoing first liver resection without concomitant other organ resections between 2006 and 2019 were included. The three‐level complexity classification was used to categorize liver resection procedures into grades I–III. We assessed the rate of cumulative postoperative complications from the time of liver resection to the time of post‐hepatectomy complications (≥ Clavien–Dindo grade II).ResultsOf the 911 patients included, 200 underwent resection of grade I procedures, 185 underwent resection of grade II procedures, and 526 underwent resection of grade III procedures. The risks of post‐hepatectomy complications changed over time and were stratified by surgical complexity. For patients at the time of liver resection, the estimated 30‐day complication rate was 21.8% for open grade I resection, 26.7% for open grade II resection, 38.4% for open grade III resection, 8.6% for laparoscopic grade I resection, and 12.5% for laparoscopic grade II resection. For patients without complications at 7 days, the estimated 30‐day complication rate decreased to 2.1% for open grade I, 9.2% for open grade II, 17.6% for open grade III, 1.3% for laparoscopic grade I, and 4.5% for laparascopic grade II.ConclusionsThe post‐hepatectomy complication risks were stratified by surgical complexity, liver resection approach, and the period without complication after liver resection.
The potassium channels: Neurobiology and pharmacology of tinnitus
Authors: Lai Haohong , Gao Minqian , Yang Haidi 
Published: December 2023

AbstractTinnitus is a widespread public health issue that imposes a significant social burden. The occurrence and maintenance of tinnitus have been shown to be associated with abnormal neuronal activity in the auditory pathway. Based on this view, neurobiological and pharmacological developments in tinnitus focus on ion channels and synaptic neurotransmitter receptors in neurons in the auditory pathway. With major breakthroughs in the pathophysiology and research methodology of tinnitus in recent years, the role of the largest family of ion channels, potassium ion channels, in modulating the excitability of neurons involved in tinnitus has been increasingly demonstrated. More and more potassium channels involved in the neural mechanism of tinnitus have been discovered, and corresponding drugs have been developed. In this article, we review animal (mouse, rat, hamster, and guinea‐pig), human, and genetic studies on the different potassium channels involved in tinnitus, analyze the limitations of current clinical research on potassium channels, and propose future prospects. The aim of this review is to promote the understanding of the role of potassium ion channels in tinnitus and to advance the development of drugs targeting potassium ion channels for tinnitus.
Cost‐effectiveness of taurolidine‐citrate in a cohort of patients with intestinal failure receiving home parenteral nutrition
Authors: Williams Thomas J. , Moy Naomi , Kaazan Patricia , Callaghan Gavin , Holtmann Gerald , Martin Neal 
Published: December 2023

AbstractBackgroundCatheter‐related bloodstream infections (CRBSIs) in patients receiving home parenteral nutrition (HPN) for chronic intestinal failure (CIF) are associated with significant morbidity and financial costs. Taurolidine is associated with a reduction in bloodstream infections, with limited information on the cost‐effectiveness as the primary prevention. This study aimed to determine the cost‐effectiveness of using taurolidine‐citrate for the primary prevention of CRBSIs within a quaternary hospital.MethodsAll patients with CIF receiving HPN were identified between January 2015 and November 2022. Data were retrospectively collected regarding patient demographics, HPN use, CRBSI diagnosis, and use of taurolidine‐citrate. The direct costs associated with CRBSI‐associated admissions and taurolidine‐citrate use were obtained from the coding department using a bottom‐up approach. An incremental cost‐effective analysis was performed, with a time horizon of 4 years, to compare the costs associated with primary and secondary prevention against the outcome of cost per infection avoided.ResultsForty‐four patients received HPN within this period. The CRBSI rates were 3.25 infections per 1000 catheter days before the use of taurolidine‐citrate and 0.35 infections per 1000 catheter days after taurolidine‐citrate use. The incremental cost‐effectiveness ratio indicates primary prevention is the weakly dominant intervention, with the base case value of $27.04 per CRBSI avoided. This held with one‐way sensitivity analysis.ConclusionTaurolidine‐citrate in the primary prevention of CRBSIs in patients with CIF receiving HPN is associated with reduced hospital costs and infection rates.