bluuebunny/crossref_metadata_2025_split huggingface dataset:
Outcomes of Per-Oral Endoscopic Myotomy in the Treatment of Esophageal Achalasia: Over One Hundred Cases in a Single Tertiary Center
Authors: Laohavichitra Kannikar , Wannaprasert Jerasak , Raranachu-ek Thawee 
Published: November 2023

Objective: To study the outcomes and complications of per-oral endoscopic myotomy (POEM) in patients with esophageal achalasia.
Materials and Methods: This retrospective observational study reviewed the medical records of esophageal achalasia patients who underwent POEM between March 2013 and September 2022. One hundred and eight cases were included.
Results: A total of 108 consecutive patients were included in this study and classified into 4 groups: 30 (27.8%) as type I; 53 (49.1%) as type II; 5 (4.6%) as type III; and 20 (18.5%) as unspecified due to unsuccessful catheter placement across the esophagogastric junction. The mean patient age was 46.10+16.59, 77 (71.3%) patients were female. Ten (9.3%) of the patients had undergone prior treatment, including balloon dilation, POEM, Heller myotomy, and nitroglycerine. Technical success was achieved in 106 (98.1%) cases, clinical success was evaluated only in 88 patients who follow up more than 6 month and the median follow-up time was 20.50 months (range 6-110 months). The clinical success was accomplished in 82 (93.2%), and 26 (24.1%) patients experienced perioperative complications which were significantly associated with anterior myotomy and probably operator learning curve. One patient (1.1%) had recurrent symptoms at 24-month follow up. Gastroesophageal reflux disease (GERD) was found in 19 (21.6%) patients, all of whom responded well to proton pump inhibitors (PPIs).
Conclusion: POEM is effective and safe in long-term treatment of achalasia. Although the incidence of symptomatic GERD was slightly high, the cases were not severe and were well controlled with medication.
Bedaquiline Effect Towards QT Interval in Drug Resistant Tuberculosis (DR-TB): A Systematic Review
Authors: Simanjuntak Arya Marganda , Aulia Rahmadini , Banjarnahor Dhewa Triguna , Harianja Riski Dimas , Yovi Indra 
Published: November 2023

Objective: Bedaquiline is recommended by World Health Organization (WHO) to treat Drug-Resistant Tuberculosis (DR-TB). Bedaquiline is chosen due to its efficacy and safety in numerous studies. One adverse event that could happen is QT interval prolongation, which increases the risk of Torsade de Pointes (TdP) and leads to death. This study aimed to discuss the knowledge on the effect of bedaquiline on before-after and changes of QT interval.
Materials and Methods: This systematic review based on PRISMA guidelines through PubMed, Cochrane, Science Direct, ProQuest, Google Scholar, and Epistemonikos until April 10, 2023. The keywords used was (“Bedaquiline” AND “QT Interval”). We implemented inclusion and exclusion criteria by PICOS framework then assessed the studies by Joanna Briggs Institute (JBI) critical appraisal checklist tools.
Results: From 1.170 articles, eleven articles met the criteria. In total 2449 patients assessed in this study. Most of the studies carried out treatment duration of 6 months. There was a change in the mean QT interval between 11ms to 52.5ms in patients using bedaquiline from the beginning to the end of treatment. The mean QT interval after treatment ranges from 409.7ms – 464.5ms.
Conclusion: The use of bedaquiline requires attention to the ECG before and during therapy. Regular monitoring is necessary to prevent QT prolongation.
Primary Sclerosing Cholangitis in Very Early Age: Two Case Reports
Authors: Nahid Khan Lamia , Begum Fahmida , Alam Rubaiyat , Islam Mohammed Shahidul , Rukunuzzaman Md 
Published: November 2023

Primary Sclerosing Cholangitis (PSC) is a rare, chronic, progressive cholestatic liver disease which affects intrahepatic and extrahepatic bile ducts. That eventually progresses to end stage liver disease that requires liver transplantation. It mostly occurs in adolescent males and boys. Pediatric disease appears milder in contrast to adult-onset PSC. The diagnosis is made by Magnatic Resonance Cholangiopancreatography (MRCP). Though there is no practical guideline available in pediatric patients for treating PSC UDCA is prescribed chronically in over 80% of patients. There is close association of PSC with inflammatory bowel disease and autoimmune hepatitis in children. So the treatment is complex in case of children. We reported here two cases of PSC, because of rarity of this disease in such a young age.
BANGLADESH J CHILD HEALTH 2022; VOL 46 (1) : 30-34
Siyaset Düşüncesi Bağlamında Telemakhos’un Maceraları’nın Tercüme-i Telemak’a Tesiri
Authors: AKTÜRKOĞLU Mustafa Enes 
Published: November 2023

François Fenelon’un Telemakhos’un Maceraları isimli eseri 17. asrın sonu 18. asrın başlarında Fransa Kralı XIV. Louis’in tahkim ettiği mutlak idareye karşı sessiz bir eleştiriyi yansıtmaktadır. Avrupa’nın Reform Hareketi sonrasında siyasal bölünmüşlüğü büyük savaşlarla birlikte hem devlet idaresini hem de istikrarı ortadan kaldırmıştır. Dolayısıyla 17. ve 18. asır Avrupalı siyaset düşünürleri devletin meşruiyetinin kaynağına yönelik tartışmalar yapmıştır. Fenelon bu bağlamda hükümdarların siyasi meşruiyetini ilahi bir kökene bağlasa da, hükümdarın sorumluluklarını sözleşmeci bir mantık üzerinden düşünmektedir. Fenelon’un sözleşmeci siyaset düşüncesi Telemakhos’un Maceraları isimli eserinde alegorik bir anlatımla ifade bulmuştur.
Telemakhos’un Maceraları, Devlet-i Aliyye’de Sultan III. Selim ve Sultan II. Mahmud’un hanedan merkezli siyasetin bir sonucu olarak ilgiyle okunmuştur. Tanzimat Fermanı sonrasında Osmanlı ricali ve düşünürlerinin Fenelon’un eserine ilgi duymasında; eserin içinde barındırdığı siyasi sözleşmeci yaklaşım olabilir. Dolayısıyla biz bu makalemizde Fenelon’un Telamakhos’un Maceraları isimli eserinin siyasi teklifi ile Yusuf Kamil Paşa’nın çevirmiş olduğu Tercüme-i Telemak eserini siyaset düşüncesi bağlamında ele almaya çalışacağız.
Links between animal welfare and “One Health”: perception and implementation in Latin America
Authors: Racciatti Débora Silvia , Wiemeyer Guillermo María , González Gracia Luis Andrés , Blanco Carlos , Szmelc Andrea , Orozco María Marcela 
Published: November 2023

IntroductionThe recent COVID-19 pandemic has highlighted the crucial role of the “One Health” (OH) concept in the prevention, early detection, and mitigation of health issues involving humans, animals, and the environment. Recognizing the intrinsic interdependence among human health, animal health, and environmental well-being is crucial, demanding heightened emphasis. Many health challenges stem from situations that compromise animal welfare (AW), human well-being, environmental sustainability, and vice versa. Recognizing the significance of AW across its five domains is essential for preventing future pandemics and advancing global objectives such as food security, reduction of human suffering, biodiversity conservation, and enhanced productivity in the agricultural-livestock sector.MethodsFrom March to May 2023, we conducted an online survey using QuestionPro® to explore perceptions, experiences, ongoing strategies, and activities within disciplines linked to AW and the OH approach in Latin America. Respondents included stakeholders from various disciplines associated with OH and AW.ResultsOur findings reveal that both concepts are currently undergoing an expansion phase in Latin America. However, the interdependencies between AW and OH are not widely recognized. While animal welfare frequently receives significant attention from diverse educational perspectives, the OH approach has gained considerable momentum over the past decade. Academic sectors and non-governmental organizations (NGOs) are driving initiatives bridging AW and OH in Latin America, underscoring the need for robust public policies to ensure sustainable strategies.DiscussionAdvocating for greater awareness of the interdependence between AW and OH, this study highlights knowledge gaps among the scientific community and policymakers. Actively engaging with these connections can foster comprehensive strategies to address global health challenges and enhance overall well-being. The “One Welfare” framework and other integrative frameworks hold promise in strengthening the linkages between AW and OH, facilitating theory translation into practical action. Establishing comprehensive, integrated policies that unite these domains is imperative for addressing complex health challenges and advancing the welfare of both animals and humans. Further research and collaborative efforts are essential to transform these concepts into tangible, impactful outcomes.
Integrative metabolomic and transcriptomic reveals potential mechanism for promotion of ginsenoside synthesis in Panax ginseng leaves under different light intensities
Authors: Di Ping , Yang Xiao , Wan Mingming , Han Mei , Zhang Yonggang , Yang Limin 
Published: November 2023

Panax ginseng C.A. Meyer is a shade plant, and its leaves are an important medicinal part of P. ginseng. Light intensity plays a crucial role in physiological activities and metabolite accumulation in P. ginseng. Currently, little is known about the molecular mechanisms underlying physiological changes and quality under different light intensities in P. ginseng leaves. Therefore, we investigated the changes in photosynthetic physiology, secondary metabolism, transcriptomics, and metabolomics of P. ginseng leaves under different light intensities [T20 (20 µmol m-2·s-1), T50 (50 µmol m-2·s−1), T100 (100 μmol m−2·s−1)]]. Higher light intensity positively influenced the yield, photosynthesis, and accumulation of polysaccharides, soluble sugars, terpenoids, and ginsenosides in P. ginseng leaves. The T100 treatment notably promoted the accumulation of ginsenosides in the leaves, resulting in a 68.32% and 45.55% increase in total ginsenosides compared to the T20 and T50 treatments, respectively. Ginsenosides Rg1, Re, Rb1, Rc, Rg2, Rb2, Rb3, and Rd were 1.28-, 1.47-, 2.32-, 1.64-, 1.28-, 2.59-, 1.66-, and 2.28-times higher than in the T20 treatment. Furthermore, 285 differentially accumulated metabolites (DAMs) and 4218 differentially expressed genes (DEGs) in the metabolome and transcriptome of P. ginseng leaves, respectively, were identified. 13 triterpenoid saponins were significantly upregulated, and three were downregulated. The expression of genes encoding photosystem II reaction center proteins was upregulated under the T100 treatment, thereby increasing photosynthetic activity. The T100 treatment enhanced the expression of genes involved in photosynthetic carbon and energy metabolism in P. ginseng. The expression of antenna protein synthesis genes was upregulated under the T20, which increased the ability to capture light in P. ginseng leaves. T100 upregulated the expression of HMGR, SS, CYP716A53v2, UGT74AE, PgUGT1, and UGTPg45, thereby promoting terpene and ginsenoside synthesis. In summary, 100 µmol m−2·s−1 was conducive to quality formation of P. ginseng leaves. This study elucidates molecular mechanisms underlying the photosynthetic physiology and ginsenoside synthesis in P. ginseng under varying light intensities and provides a theoretical basis for the P. ginseng cultivation and its industrial production of secondary metabolites.
Poly I:C-priming of adipose-derived mesenchymal stromal cells promotes a pro-tumorigenic phenotype in an immunocompetent mouse model of prostate cancer
Authors: Rivera-Cruz Cosette M. , Kumar Shreya , Figueiredo Marxa L. 
Published: November 2023

Introduction: Mesenchymal stromal cells (MSC) are envisioned as a potential cellular vehicle for targeted cancer therapies due to their tumor tropism and immune permissiveness. An obstacle in their use is the duality in their interactions within tumors, rendering them pro-tumorigenic or anti-tumorigenic, in a context dependent manner. MSC preconditioning, or priming, has been proposed as a strategy for directing the effector properties of MSC at tumor sites.Methods: We primed human MSC derived from adipose tissues (ASC), a clinically advantageous MSC source, utilizing toll-like receptor agonists. Subsequently, we explored the consequences in tumor progression and transcriptome upon the interaction of tumor cells with primed or unprimed ASC in an in vivo model of prostate cancer, the second most common cancer and second leading cause of cancer related death in men in the USA.Results and discussion: In the studied model, poly I:C-primed ASC were found to significantly accelerate tumor growth progression. And while unprimed and LPS-primed ASC did not exert a significant effect on tumor growth at the macroscopic level, gene expression analyses suggested that all treatments promoted distinct modulatory effects in the tumor microenvironment, including altered modulation of angiogenesis, and immune response processes. However, the effects resulting from the collective interaction across these processes must be sufficiently skewed in a pro-tumorigenic or anti-tumorigenic direction for evidence of tumor progression modulation to be detectable at the macroscopic level. Our study highlights potential MSC-tumor microenvironment interactions that may be leveraged and should be considered in the development of cancer therapeutics utilizing MSC.
Drug target, class level, and PathFX pathway information share utility for machine learning prediction of common drug-induced side effects
Authors: Liu Han Jie , Wilson Jennifer L. 
Published: November 2023

Introduction: Development of drugs often fails due to toxicity and intolerable side effects. Recent advancements in the scientific community have rendered it possible to leverage machine learning techniques to predict individual side effects with domain knowledge features (i.e., drug classification). While several factors can be used to anticipate drug effects including their targets, pathways, and drug classes, it is unclear which domain knowledge is most predictive and whether certain domain knowledge is more important than others for different side effects.Methods: The goal of this project is to understand the predictive values of drug targets, drug classification (i.e., level 2 ATC codes), and protein-protein interaction networks (i.e., PathFX targets and network proteins) for machine learning prediction of 30 frequently occurring drug-induced side effects.Results: We compared the prediction accuracy for individual side effects of trained models across five domain knowledge combinations and discovered that level 2 ATC codes have the highest predictive value across the domain knowledge features. Logistic regression coefficient analyses further suggest that side effects are more dependent on drug targets and drug classes, and less so on PathFX targets and network proteins.Discussion: Our quantitative assessments may inform the development of safe and effective drugs by understanding the domain knowledge features underlying frequently occurring drug-induced side effects.
Evaluation of adipokines concentrations in plasma, peritoneal, and endometrioma fluids in women operated on for ovarian endometriosis
Authors: Wójtowicz Mariusz , Zdun Dariusz , Owczarek Aleksander Jerzy , Skrzypulec-Plinta Violetta , Olszanecka-Glinianowicz Magdalena 
Published: November 2023

IntroductionSome studies indicate the role of selected adipokines in the development of endometriosis. However, a comprehensive assessment of plasma, peritoneal, and endometrioma fluids adipokines concentrations in women with ovarian endometriosis has not yet been performed. Therefore, this study aimed to analyze plasma, peritoneal, and endometrioma fluids selected adipokines concentrations in women operated on for ovarian endometriosis.Materials and methodsA cross-sectional cohort study involved 56 women operated on for ovarian endometriosis. Body mass, height, and waist circumference were measured, and BMI was calculated. Plasma, peritoneal, and endometrioma fluids adiponectin, leptin, omentin resistin, RBP4, and visfatin/NAMPT were determined by ELISA.ResultsThe highest plasma levels of adiponectin, leptin, omentin, and RBP4 than in the endometrioma and peritoneal fluids were found, while levels of resistin and visfatin/NAMPT were significantly higher in endometrioma fluid than in plasma and peritoneal fluid. In addition, levels of visfatin/NAMPT were significantly higher in peritoneal fluid than in plasma. There were also positive correlations between leptin, RBP4, and adiponectin levels in endometrioma and peritoneal fluids (ρ = 0.28; p &lt; 0.05; ρ = 0.31; p &lt; 0.05; ρ= 0.32; p &lt; 0.05, respectively). There were no associations between adipokines levels in plasma, endometrioma, and peritoneal fluids and endometriosis stage.ConclusionOur results show that visfatin/NAMPT and resistin may be locally secreted in endometrioma related to inflammation regardless of the stage of endometriosis.
Analysis of risk factors for recurrence in infertile endometrial cancer patients after in vitro fertilization treatment
Authors: Wei Hongyi , Pan Ningning , Wang Yang , Ma Caihong 
Published: November 2023

PurposeTo investigate the oncologic outcomes of patients with early-stage endometrioid endometrial cancer (EEC) treated with in vitro fertilization/intracytoplasmic sperm injection (IVF/ICSI) following fertility-sparing treatment (FST).MethodsA total of 62 patients who underwent IVF/ICSI treatment in a single fertility center between June 2010 and December 2021 after conservative treatment for early-stage EEC were assigned to a recurrence group and a non-recurrence group. Their clinical characteristics and disease outcomes were retrospectively evaluated.ResultsThe 62 women with complete remission (CR) after FST for EEC underwent 103 IVF cycles, resulting in 41 fresh embryo transfers (ETs) and 70 frozen–thawed transfers; 27 (43.55%) achieved clinical pregnancies, and 20 (32.26%) gave birth to a total of 23 live neonates. Additionally, nine patients had live births from natural pregnancies after IVF failure, bringing the cumulative live birth rate to 46.77% (29/62). After a median follow-up period of 53.88 months (range 20.2–127.5 months), 17 patients (27.42%) experienced recurrence within 2.8 to 57.9 months after the first controlled ovarian stimulation (COS). The probability of relapse at 1, 2, and 3 years after the initiation of COS was 14.52% (9/62), 21% (13/62), and 25.81% (16/62), respectively. Factors such as the time to CR, the time to IVF, the frequency of COS, maintenance treatment before IVF, and histology type were not found to significantly affect recurrence (p = 0.079, 0.182, 0.093, 0.267, and 0.41, respectively). Live births (hazard ratio (HR): 0.28, 95% CI: 0.082–0.962, p = 0.043) and the protocol of letrozole plus gonadotropin-releasing hormone (GnRH) antagonist/agonist used during IVF (HR: 0.1, 95% CI: 0.011–0.882, p = 0.038) were identified as independent favorable factors for recurrence.ConclusionsLive birth was associated with decreased recurrence of EEC. Reducing estrogen levels during COS may serve to mitigate the risk of endometrial cancer recurrence.
The association between sleep and early pubertal development in Chinese children: a school population-based cross-sectional study
Authors: Tang Jingyi , Yu Tingting , Jiang Yanrui , Xue Peng , Kong Huijun , Lin Cuilan , Liu Shijian , Tian Ying 
Published: November 2023

BackgroundThere is an increasing tendency toward early pubertal development, and sleep might be related to pubertal onset. We aimed to investigate the association of sleep duration and bedtime with early pubertal development.MethodsThis was a cross-sectional study of 8,007 children (53.6% boys) from Qufu city, Shandong province and Zhongshan city, Guangdong province, China. Data on sleep duration and bedtime were obtained by questionnaire. Early pubertal development was the primary outcome and it was evaluated by the pediatrician according to Tanner staging. Logistic regression models were used to separately examine the association between sleep duration or bedtime and early pubertal development, controlling body mass index (BMI), dietary pattern, soft drink, feeding pattern and mother’s BMI.ResultsIn boys, short sleep duration was strongly related to early pubertal development [OR (95%CI): 4.26 (1.30, 13.94)], and this association was intensified after adjusted BMI, dietary pattern, soft drink, feeding pattern and mother’s BMI. In girls, OR (95%CI) was 1.62 (1.04, 2.51), and increased after controlling BMI. Bedtime was associated with early pubertal development on weekdays [OR (95%CI): 6.39 (1.54, 26.45) in boys and 1.93 (1.23, 3.05) in girls], but not on weekends [OR (95%CI): 2.49 (0.61, 10.21) in boys; 1.31 (0.76, 2.25) in girls].ConclusionThis study underscores the positive association between the risk of early pubertal development and insufficient sleep duration and late bedtime.
Vanadium, cobalt, zinc, and rubidium are associated with markers of inflammation and oxidative stress in a Greek population with obesity
Authors: Amerikanou Charalampia , Kleftaki Stamatia-Angeliki , Karavoltsos Sotirios , Tagkouli Dimitra , Sakellari Aikaterini , Valsamidou Evdokia , Gioxari Aristea , Kalogeropoulos Nick , Kaliora Andriana C. 
Published: November 2023

IntroductionThe prevalence of obesity is rising globally, with negative effects on the socioeconomic system. As a result of its drivers which include low-grade chronic inflammation, oxidative stress, and fatty acid metabolism, this phenotype develops metabolic anomalies that exacerbate its pathogenesis. It has been discovered that metals and metalloids have substantial effects on both the immune system and metabolism and are influenced by factors connected to obesity. Although there is a known connection between metals, obesity, and related metabolic disorders, it is still under research.MethodsWe determined the plasma levels of 16 metals and metalloids in 76 individuals with obesity and investigated the relationships with inflammatory and oxidative stress biomarkers in order to clarify the processes by which metals/metalloids exhibit their effects.ResultsAfter adjusting for age, gender, BMI, physical activity level, smoking, the existence of metabolic abnormalities, and dietary intake of the corresponding metal, regression analysis revealed the following statistically significant associations; vanadium was negatively associated with oxLDL (Beta ± SE= -0.014 ± 0.005, p=0.007), zinc was negatively associated with leptin (Beta ± SE= -12.390 ± 5.226, p=0.025), cobalt was associated negatively with adiponectin (Beta ± SE= -0.030 ± 0.012, p=0.001) and positively with MPO (Beta ± SE= 0.002 ± 0.001, p=0.023), and rubidium was negatively associated with oxLDL (Beta ± SE= -1.139 ± 0.411, p=0.008) and positively with MPO (Beta ± SE= 0.324 ± 0.102, p=0.003).DiscussionThe aforementioned associations highlight the need for further research, demonstrating the importance of inflammation and oxidative stress in the association between metals/metalloids and obesity-related metabolic abnormalities.