bluuebunny/crossref_metadata_2025_split huggingface dataset:
Un bosque urbano en el desierto: conservación de la biodiversidad en Lima, Perú
Authors: Orellana Asenjo Giancarlo Jeremy , Gamarra Bustamante Julio André , Móstiga Rodríguez Maricel Jadith , Morales Moquillaza Luisa Grisell , Bulnes Soriano Carlos Fernando , Yancce Velarde Rocío Yovana 
Published: December 2023

La creciente urbanización mundial convierte a la conservación de los bosques urbanos en una estrategia fundamental para alcanzar la sostenibilidad y el bienestar humano. Lima, una megaciudad ubicada en el desierto, no cuenta con la infraestructura verde para afrontar las múltiples problemáticas. Es así como en el “Vivero Forestal” de la Universidad Nacional Agraria La Molina (UNALM) se viene desarrollando el proyecto “Centro de la Diversidad Natural y Cultural del Perú”, que tiene por finalidad ser la principal muestra viva de la riqueza florística y cultural del país. Este estudio tiene por objetivo evidenciar la conservación de la biodiversidad presente en el bosque urbano Vivero Forestal. Para ello, se realizó un censo de los árboles, palmeras y algunos arbustos y herbáceas, y una revisión bibliográfica para identificar las especies de fauna silvestre. Asimismo, se identificó la procedencia según su distribución natural y aquellas que estuvieran amenazadas. El Vivero Forestal alberga en sus 25 hectáreas a 5898 individuos, en su mayoría visualmente sanos (78 especies forestales y 31 familias botánicas), de los cuales el 25% se encuentra en peligro de extinción (11especies). Además, presenta 32 especies forestales nativas del Perú (10 de la costa, siete de la sierra y 15 de la selva). El vivero es, principalmente, el hábitat de especies de la faunacostera. Hay 66 especies de aves, de las cuales tres están en peligro de extinción; una especie de anfibios; cuatro especies de murciélagos; una especie de roedores y cuatro especies de reptiles, de las cuales dos están amenazadas. El estudio resalta al Vivero Forestal como uno de los espacios más biodiversos de la ciudad de Lima y reconoce su potencial para convertirse en parte de la Red de Jardines Botánicos Nacionales del Perú.
La Educación rural en América Latina y el Caribe: Pasado y Presente
Authors: Mansilla Sepúlveda Juan Guillermo 
Published: December 2023

La presente edición de la Revista Historia de la Educación Latinoamericana se focaliza en el debate en perspectiva histórica de la Educación Rural (Educação do Campo) en algunos territorios de América Latina y el Caribe. Se presenta un dossier con doce artículos dedicados en gran parte a escuelas, profesorado y estudiantes que han dejado huellas relevantes en las escuelas rurales de América Latina (Abya-Yala). La educación rural, es por esencia, el ámbito social en que adquiere verdadero sentido el despliegue de aprendizajes expansivos e inclusivos, pues las escuelas situadas en los campos responden permanentemente a los requerimientos de su entorno social y cultural. No obstante, y a partir de la evidencia empírica disponible, nos atrevemos a decir que la constitución sociohistórica de la distribución social del conocimiento es marcadamente desigual en los mundos escolares rurales. El sistema escolar, en general, ha contribuido a reproducir esa desigualdad.
Screening competition and cross-feeding interactions during utilization of human milk oligosaccharides by gut microbes
Authors: Díaz Romina , Garrido Daniel 
Published: December 2023

Background: The infant gut microbiome is a complex community that influences short- and long-term health. Its assembly and composition are governed by variables such as the feeding type. Breast milk provides infants an important supply of human milk oligosaccharides (HMO), a broad family of carbohydrates comprising neutral, fucosylated, and sialylated molecules. There is a positive association between HMOs and the overrepresentation of Bifidobacterium species in the infant gut, which is sustained by multiple molecular determinants present in the genomes of these species. Infant-gut-associated Bifidobacterium species usually share a similar niche and display similar HMO inclinations, suggesting they compete for these resources. There is also strong evidence of cross-feeding interactions between HMO-derived molecules and bifidobacteria.
Methods: In this study, we screened for unidirectional and bidirectional interactions between Bifidobacterium and other species using individual HMO. Bifidobacterium bifidum and Bacteroides thetaiotaomicron increased the growth of several other species when their supernatants were used, probably mediated by the partial degradation of HMO. In contrast, Bifidobacterium longum subsp. infantis . supernatants did not exhibit positive growth.
Results: Bifidobacterium species compete for lacto-N -tetraose, which is associated with reduced bidirectional growth. The outcome of these interactions was HMO-dependent, in which the two species could compete for one substrate but cross-feed on another. 2’-fucosyllactose and lacto-N -neotetraose are associated with several positive interactions that generally originate from the partial degradation of these HMOs.
Conclusion: This study presents evidence for complex interactions during HMO utilization, which can be cooperative or competitive, depending on the nature of the HMO. This information could be useful for understanding how breast milk supports the growth of some Bifidobacterium species, shaping the ecology of this important microbial community.
INTEGRATION OF HEATING SYSTEM OPERATION
Authors: Selikhov Yu.A. , Rishchenko I.M. , Gorbunov K.A. 
Published: December 2023

Ukraine has a huge asset in the form of existing district heating (DH) networks and demand for related services. DH is transforming the European energy sector, attracting efficient, local and renewable energy resources where this was not possible. However, due to the old material base of spare parts, insufficient level of investment and low level of management, Ukrainian DH systems are ineffective and do not meet the needs of consumers. The experience of European Union member states in central Europe shows that deep and sustained reforms can address the current challenges of the heating sector, including improving energy efficiency and economic competitiveness, strengthening environmental sustainability and enhancing energy security. The DH sector in Ukraine has not yet undergone the structural reform that other sectors of the economy have already gone through: over the past 30 years, the quality of services has decreased; subsidies have increased; the old material base is falling apart; The question arises whether it is worth continuing to support DH. As a result, Ukraine's DH sector is in dire straits, with financial, operational and technical problems compounding each other. Comprehensive and well-planned efforts must be made to create the conditions for exiting this state. Such structural reforms are essential to attracting the investment needed to improve the quality, efficiency and long-term potential of the district heating sector.
The article examines the possibility of using modern technological solutions to modernize heat supply systems in order to improve their efficiency, which can lead to improved district heating services, transparency and financial stability.
Keywords: energy resources, renewable energy sources, fossil fuels, automated heat and power plant, electricity, hot water, hot air, heating, private households, electric water heater, geothermal heat pump, wind power generator, low-power boiler house.
Intraoperative Ultrasound for Extracting Deep-Seated Radio-Opaque Foreign Body from Calf
Authors: Metikala Sreenivasulu , Munagala Venkata Manvith , Carroll Colin J. , Cheppalli Naga S. 
Published: December 2023

Case:
A 50-year-old man presented with chronic refractory symptoms of radiating leg pain with muscle cramps because of a retained bullet in the calf after being shot in 1990. Radiographs confirmed the bullet lodged in posterolateral aspect of calf abutting proximal fibula. An intraoperative point-of-care ultrasound aided in accurate localization of bullet, thereby facilitating precise planning of surgical incision and subsequent removal.

Conclusions:
Ultrasound can be used as an alternative tool for safe surgical extraction of deep-seated metallic object with minimal tissue dissection, obviating the need for C-arm.
Sex and gender in perioperative cardiovascular research: a protocol for a scoping review
Authors: Sjaus Ana , Fakhory Nicole 
Published: December 2023

Abstract

Background
Inadequate inclusion of sex and gender in medical research has resulted in biased clinical guidance and disparities in knowledge and outcomes. Despite decades of efforts by regulatory and funding agencies, opportunities to generate sex specific knowledge are routinely neglected. Certain disciplines in cardiovascular medicine have made great strides, however, these advances have yet to permeate the literature on perioperative cardiovascular complications in non-cardiac surgery.
Prompted by the recent findings on sex-specific perioperative cardiovascular outcomes, this review aims to scope the literature in this field and categorize methodological approaches used to incorporate sex and gender as variables in this patient population.
Methods
Joanna Briggs Institute (JBI) methodology for scoping reviews will be followed in stages elaborated by Levac (2010). Detailed search strategy will be used to identify relevant primary research published since 2010. Screening against inclusion and exclusion criteria will be performed by independent reviewers. Data will be extracted from full text and additional materials of articles in the final selection. Results will be presented as proportions of studies reporting sex and gender, the assigned purpose of these variables in analysis and where they were reported in the article. In addition, articles will be mapped to the source, country of origin, and year of publication. Narrative summaries will be used to outline major findings and the depth of literature within each of the major topics (risk assessment/prediction, diagnosis, treatment, prognosis, and outcomes).
Discussion
Rising awareness of profound and complex implications of sex and gender in medicine has prompted calls for greater attention to participation equity, sex specific analysis and reporting. Focusing on perioperative cardiovascular complications, this study has the potential to identify knowledge gaps for further research, as well as areas of strength that could support formal knowledge synthesis or secondary analysis of data from past research.
Scoping Review Registration
Submitted on August 15th, 2023 (Web of Science osf.io/u25sf, pending approval)
The long-term impact of carbon emission trading and renewable energy support policy on China's power sector under the context of electricity marketed reform: an analysis based on system dynamics
Authors: Yue Wang , Haocheng Wei , Hao Shuai , Chen Xie , Xiaoyi Wang 
Published: December 2023

Abstract
China's power industry is currently undergoing a significant transition driven by the imperative of dual-carbon goal. To facilitate the successful transition of this sector, the government has implemented a series of targeted policies and reforms. These measures primarily encompass carbon emission trading (CET), renewable energy support policy, and electricity marketed reforms. The profound implications of these policies for China's power industry warrant investigation. To address this, this study constructs a comprehensive system dynamics model that delineates the intricate interplay between CET, renewable energy support policy, and electricity market reforms. Simulation results show that: (1) Under marketed on-grid price, electricity price exhibit a transient decline followed by a gradual ascent, peaking around 2045. This price trajectory stems from augmented power generation costs prompted by the imperative of carbon emission reduction and power sector transition. This finding diverges from some earlier studies suggesting a steep decline in electricity price following the adoption of marketed on-grid price. (2) CET can promote carbon reduction in power sector. Under the aegis of CET, carbon peaking within the sector is slated for realization by 2030. However, the introduction of renewable energy support policy yields some adverse effects on CET through price pass-through mechanisms. Yet, in parallel, it facilitates a notable enhancement in the overall proportion of renewable energy in end-use energy consumption. (3) A comparative evaluation of feed-in tariffs (FIT) and renewable portfolio standards (RPS) unveils distinct suitability profiles. FIT proves optimally aligned with the initial stages of renewable energy's pre-development and early expansion. In contrast, RPS manifests as an optimal choice post-technological maturation, concurrently alleviating the governmental financial load. (4) The context of marketed on-grid price augments the cost-effectiveness of carbon capture and storage (CCS). This incentivizes thermal power plants to embrace low-carbon technologies, fostering a conducive milieu for curtailing carbon emission. Based on these results, a number of policy implications are provided for the long-term development of China's power sector.
A mpox quadrivalent mRNA vaccine protects mice from a lethal vaccinia virus challenge
Authors: Chiu Sandra , Li Entao , Gong Qizan , Zhang Jiachen , Guo Xiaoping , Xie Wenyu , Chen Da , Shen Yanqiong , Hong Dongxiang , Li Zhihao , Wang Qianqian , Wang Chao , Wang Yucai 
Published: December 2023

Abstract

The outbreak of 2022 mpox virus (MPXV) infection in nonendemic regions is a global public health concern. A highly effective and safe MPXV vaccine that is available to the general public is urgently needed to control the MPXV pandemic. Here, we developed a polyvalent mRNA vaccine candidate, MPXV-1103, which expresses full-length B6R, A35R, A29L and M1R antigens with flexible linker-(G4S1)3 in a single sequence. Compared to the monovalent mpox mRNA vaccine candidates, MPXV-1103 elicits a stronger robust humoral response and MPXV-specific T-cell response and protects mice from a lethal vaccinia virus challenge with no live virus detected in the nasal and lungs even at dosages as low as 1 µg. Furthermore, the analysis of complete blood counts and photomicrographs of tissue in the main organs from mice vaccinated with MPXV-1103 at doses of 5 µg and 20 µg showed that two doses of MPXV-1103 vaccination did not cause observable pathologic changes in mice. Collectively, our results suggest that MPXV-1103, with features of high efficacy, safety and a simplified manufacturing process, is a promising vaccine candidate to defend against MPXV infection.
Autonomous Self-Healing Supramolecular Polymer Transistors for Skin Electronics
Authors: Oh Jin Young , Vo Ngoc Thanh Phuong , Jeong Min Woo , Kim Jun Su , Jung Kyu Ho , Lee Yeongjun , Ma Guorong , Gu Xiaodan , Tok Jeffrey , Nam Tae Uk , Lee Tae Il , Bao Zhenan 
Published: December 2023

Abstract

Skin-like field-effect transistors are key elements of bio-integrated devices for future user-interactive electronic-skin applications. Despite recent rapid developments in skin-like stretchable transistors, imparting self-healing ability while maintaining necessary electrical performance to these transistors remains a challenge. Herein, we describe a stretchable polymer transistor capable of autonomous self-healing. The active material consists of a blend of an electrically insulating supramolecular polymer with either semiconducting polymers or vapor-deposited metal nanoclusters. A key feature is to employ the same supramolecular self-healing polymer matrix for all active layers, i.e., conductor/semiconductor/dielectric layers, in the skin-like transistor. This provides adhesion and intimate contact between layers, which facilitates effective charge injection and transport under strain after self-healing. Finally, we fabricate skin-like self-healing circuits, including NAND and NOR gates and inverters, both of which are critical components of arithmetic logic units. This work greatly advances practical self-healing skin electronics.
Activation of IP10/CXCR3 signaling is highly coincidental with the deposition of PrPSc in the brains of scrapie-infected mice
Authors: Chen Jia , Chen Cao , Hu Chao , Yang Wei , Wang Lin , Chen Dong-Dong , Wu Yue-Zhang , Shi Qi , Dong Xiao-Ping 
Published: December 2023

Abstract
The chemokine IP10 and its receptor CXCR3 are activated in CNS during various neurodegenerative diseases. Our previous study demonstrated elevated levels of IP10 in the brains of several scrapie rodent models. However, the precise modulation of IP10/CXCR3 signaling in CNS during prion infection remains unresolved. Here, we observed an upregulation of IP10 signals primarily localized in neurons within the brains of scrapie-infected mice using various methodologies. Both CXCR3 levels and activation were significantly increased in the brains of scrapie-infected mice and in the prion-infected cell line SMB-S15. Enhanced CXCR3 expression was predominantly observed in neurons and activated microglia. Morphological colocalizations of PrPC/PrPSc with IP10 and CXCR3 were observed in the brains of scrapie-infected mice through IHC and immunofluorescence. IHC analysis using whole brain sections revealed increased accumulation of IP10 and CXCR3 specifically occurred in brain regions with higher levels of PrPSc deposits. Co-immunoprecipitation and biomolecular interaction assays suggested molecular interactions of PrP and IP10 as well as CXCR3. Notably, a significantly larger amount of IP10 accumulated within prion-infected SMB-S15 cells compared to the normal partner cell line SMB-PS. Importantly, treatment with resveratrol effectively suppressed prion replication in SMB-S15 cells, restoring the pattern of accumulation and secretion of cellular IP10 similar to that observed in SMB-PS cells. Our data presented herein demonstrate the activation of IP10/CXCR3 signaling in prion-infected brain tissues coinciding with the deposition of PrPSc. Modulating IP10/CXCR3 signaling in the brain represents a potential therapeutic target for mitigating the progression of prion diseases.
Physico- Chemical and Biological Investigations of Ocimum Basilicum L. Cultived in Algeria
Authors: Merzouki Soraya , Boukeria Sabah , Louafi Fadila , Alma Mohemet Hakki , Erenler Ramazan , Yeldiz Ilyas , Boulkroune Mina , Mouats Chabane 
Published: December 2023

Abstract
The study aims to explore biologically active substances from natural sources for potential medicines from the Ocimum basilicum L. plant. The MC-MS analysis reveals that the majority of compounds in the arial portion of this plant are Hesperidin and Vanillic acid, which are used in treating blood vessel fragility and neurological diseases like Alzheimer's and Parkinson's. The study conducted a qualitative phytochemical screening of the extract, revealing different secondary metabolites. Quantitative studies were conducted to determine the quantities of polyphenols, flavonoids, tannins, and alkaloids in the extract. Our investigations also assessed the extract's antioxidant activity using DPPH free radical scavenging and cyclic voltammetry, providing insights into its potential to combat oxidative stress. Finally, the hydrometanolic plant extract's anticoagulant activity was examined through Quick and Cephaline Kaolin time coagulation exploration tests, providing insights into its impact on coagulation pathways.
Assessment of the Pterygoid Hamulus Dimensions and Morphology in Iranian Women Using Cone-Beam Computed Tomography
Authors: Mahdavi Zahra , Hafezi Ladan 
Published: December 2023

Abstract
Objectives:
This study aimed to evaluate the morphology and dimensions of the pterygoid hamulus (PH) and its changes by ageing in 20-40-year-old women in the Dental Branch of the Islamic Azad University of Sciences, Tehran, Iran.
Materials and Methods:
This cross-sectional study was conducted on cone-beam computed tomography (CBCT) scans from 258 women aged 20-40. The morphology, length, width, and angle of the PH in coronal and sagittal planes were investigated.
Results:
The average length of the right and left hamulus was 5.50±1.37 and 5.37±1.36 mm. The average width of the right and left hamulus was 2.16±0.72 and 2.11±1.06 mm. The average coronal angle of the right and left hamulus was 22.3±9.79° and 30.16±8.99°. The average sagittal angle of the right and left hamulus was 26.11±7.26° and 26.34±7.63°. In contrast with the sagittal angle, the right and left hamulus’s length, width, and coronal angles were not symmetrical. Slender morphology was the most frequent morphology, and it was symmetrical only in the 20-30-year-old age group. Finally, no variable was affected by ageing.
Conclusions:
Hamulus dimensions and morphology did not change with ageing in women aged 20-40. The PH symmetry varied by age group. Also, CBCT was a suitable tool for investigating hamulus changes.
Clinical Relevance:
Understanding the characteristics of the PH is crucial for diagnosing and treating various oropharyngeal and craniofacial conditions. It also aids in interpreting radiographs and diagnosing unexplained oropharyngeal pains. CBCT is a valuable tool for precisely visualising these structures, offering clinical insights into this previously understudied area.
Identification of ZMIZ2 as a co-activator enhancing SIRT1 deacetylase activity in regulating Wnt and Hippo signalling pathways
Authors: Han Qiang , Gan Xueting , Feng Yuheng , Liu Yang , Lin Xuyong , Yu Xinmiao , Rong Xuezhu 
Published: December 2023

Abstract
Zinc finger MIZ-type containing 2 (ZMIZ2) is recognized as a ‘co-activator’ involved in embryonic development and the progression of certain malignant tumours. However, its expression and molecular mechanism in non-small cell lung cancer remain inadequately understood. Additionally, the relevant “assisted factors” of ZMIZ2 remain incompletely identified. Therefore, this study aims to investigate ZMIZ2 expression in non-small cell lung cancer tissue samples and cell lines through immunohistochemistry and immunoblotting. The goal is to establish its correlation with advanced pTNM staging, lymph node metastasis, and poor prognosis. Several in vivo and in vitro functional experiments have consistently shown that the introduction of ZMIZ2 promotes the proliferation, migration, and invasiveness of lung cancer cells, thus establishing its role as a promoter of oncogenes. Investigating the molecular mechanism, we applied mass spectrometry analysis and immunoprecipitation experiments, leading to the identification of the deacetylase Sirtuin 1 (SIRT1) as an ‘assisted key factor’ capable of interacting with ZMIZ2. Furthermore, KEGG enrichment analysis suggests that ZMIZ2 is closely related to the Wnt and Hippo pathways. Furthermore, we validated that the interaction between ZMIZ2 and SIRT1 enhances SIRT1 deacetylase activity. This direct downregulation of intranuclear β-catenin and YAP acetylation levels occurs independently of upstream proteins in the Wnt/Hippo pathways. It amplifies β-catenin-TCF4 and YAP-TEAD transcriptional activities, thereby regulating the Wnt and Hippo pathway. This results in the malignant transformation of lung cancer cells, providing a relevant experimental basis for searching for new biomarkers and the development of tumour-targeted medications.