bluuebunny/crossref_metadata_2025_split huggingface dataset:
Stability analysis of evolutionary dynamics of 2 × 2 × 2 asymmetric games
Authors: Song Sha , Pan Qiuhui , Gao Xubin , He Mingfeng 
Published: January 2024

In biology, economics, sociology as well as other fields, there is often a

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asymmetric evolutionary game problem in which each party has a set of strategies, and different strategy combinations correspond to the specific pay-offs of each party. Since each participant dynamically adjusts the strategy for maximizing their own interests, the pay-off matrix plays an important role in the evolution of the game system. Based on the pay-off matrix, we probe into the resulting state of

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asymmetric evolutionary games. The results show that from the information of the pay-off matrix, the judgement conditions for the system to evolve into three pure strategies, two pure strategies and one pure strategy can be determined directly. What is more, under a certain type of fixed pay-off matrix, the strategy combinations observed at different evolution times is always varying. Here, we explore the connection between the pay-off matrix and the evolution of behaviours through stability theory, and results obtained are conducive to deeply understand and predict the dynamic evolution of behaviour in game systems.
Dynamics of elastic lattices with sliding constraints
Authors: Cabras L. , Bigoni D. , Piccolroaz A. 
Published: January 2024

This study investigates the impact of sliders – constraints acting on elastic rods allowing for a transverse displacement jump while maintaining axial and rotational displacement continuity – on the dynamics of a periodic elastic grid, including the effects of axial preload. The grid is linearly elastic and subject to in-plane incremental deformation, involving normal and shear forces and bending moment. The periodicity of the infinite grid permits a Floquet–Bloch wave analysis and a rigorous dynamic homogenization, leading to an equivalent prestressed elastic solid. The investigation is complemented by
ad hoc
developed F.E. simulations and perturbations with a pulsating Green’s function. Results show that the sliders create band gaps, flat bands and Dirac cones in the dispersion diagrams and generate macro-instability even for tensile prestress. The latter corresponds to the loss of ellipticity at the parabolic boundary in the equivalent elastic solid and provides a rare example of an almost unexplored form of material instability. Therefore, our results offer design strategies for metamaterials and architected materials showing reversible material instabilities and filtering properties for mechanical signals.
Kinematics and dynamics of non-developable origami
Authors: Zou Yu , Feng Fan , Liu Ke , Lv Pengyu , Duan Huiling 
Published: January 2024

Non-developable origami is a unique type of origami structures that cannot be unfolded into a flat sheet without stretching. In this work, we study the kinematics and dynamics of such origami, theoretically, numerically and experimentally, considering rigid panels and stretchable creases. Unlike developable origami, we find that non-developable origami exhibits distinct folding angle relationships, leading to several separate branches in its kinematic configuration space with snap-through and locking behaviours. By modelling the creases as stretchable torsional springs, we derive a dynamic model to analyse the deployment of non-developable origami structures, from single-vertex origami to origami chains. Our dynamic model unveils the snap-through behaviour between the two kinematics branches of the single-vertex non-developable origami structure, which is further validated by experiments with excellent agreement. We believe that our kinematic and dynamic framework of non-developable origami will greatly expand the current design space of origami structures and guide the design of novel origami actuators.
Development of selective isolation media for detecting Actinomyces and Schaalia genera from oral specimens containing indigenous bacteria
Authors: Aoki Sadao , Yahara Hiroko , Nakao Ryoma , Tsuzukibashi Osamu , Yahara Koji 
Published: January 2024

To isolate specific bacteria from samples constituting the microbiota, it is essential to employ selective media that suppress the growth of resident bacteria other than specific target bacteria. Selective media for clinically important Actinomyces (including Schaalia, which was previously taxonomically classified as part of the Actinomyces genus) have been limited because they have been designed for a limited range of species within the genus and require ingredients which are difficult to prepare and handle. This study aimed to develop a selective medium (referred to as Actinomyces and Schaalia Selective Medium (ASSM)) for the isolation of a broad range of Actinomyces and Schaalia species from samples mixed with resident bacteria. The composition of ASSM includes yeast extract, agar, brain heart infusion (BHI), levofloxacin (LVFX), fosfomycin (FOM), colistin (CL), and metronidazole (MNZ). Evaluation of the medium using 24 swab samples serially collected from the roots of the teeth of a healthy individual for whom metagenome sequencing data of a saliva sample are publicly available revealed that ASSM adjusted to concentrations of LVFX 0.5 mg/L, FOM 5 mg/L, CL 1 mg/L, and MNZ 2 mg/L and cultured anaerobically at 35°C for 7 days enabled the isolation of Actinomyces species from 37.5% of the samples. The inclusion of CL and MNZ in ASSM can also be useful for samples suspected of harbouring other bacterial species. The selective isolation medium is expected to contribute to studies investigating the relationship between these bacteria and their pathogenesis or disease.
Influence of social determinants of health on quality of life in patients with multimorbidity
Authors: Ruiz-Baena José María , Moreno-Juste Aida , Poblador-Plou Beatriz , Castillo-Jimena Marcos , Calderón-Larrañaga Amaia , Lozano-Hernández Cristina , Gimeno-Miguel Antonio , Gimeno-Feliú Luis A ,   MULTIPAP GROUP
Published: January 2024

AbstractBackgroundMultimorbidity, especially among older patients, is one of the biggest challenges faced by modern medicine, and is influenced by social determinants of health, giving rise to health inequalities in the population. Here, we sought to determine the influence of social determinants of health on quality of life in patients with multimorbidity.Methods and MaterialsThis cross-sectional observational study included 573 patients aged 65–74 with multimorbidity (≥3 diseases) and polypharmacy (≥5 drugs). Corresponding data was taken drawn from the Spanish MULTIPAP study, and included social and demographic variables, and data on health-related quality of life and overall self-perceived health status, assessed using the 5-level version of the EuroQol 5-dimensional questionnaire (EQ-5D-5L). Descriptive, bivariate and multivariate analyses with logistic regression models were performed.ResultsMean patient age was 69.7 years, 55.8% of patients were female, 59.7% belonged to low social classes (V, VI), a monthly income of 1051–€1850 predominated, and the median number of diseases in the same patient was 6. Factors associated with higher quality of life were male gender (OR=1.599, p=0.013), a higher educational level (OR=1.991, p=0.036), an absence of urban vulnerability (OR=1.605, p=0.017), and the presence of medium social support (OR=1.689, p=0.017). Having a higher number of diseases was associated with poorer quality of life (OR=0.912, p=0.017).ConclusionsOur findings describe associations between social determinants of health and quality of life in patients aged 65–74 years with multimorbidity and polypharmacy. More illnesses, female gender, a lower education level, urban vulnerability, and less social support are associated with poorer quality of life, underscoring the need for a biopsychosocial approach in patient care.
Unveiling the regulatory role of GRP7 in ABA signal-mediated mRNA translation efficiency regulation
Authors: Zhang Jing , Xu Yongxin , Tian Fa’an , He Chongsheng , Yu Xiang , Yang Xiaofei , Ding Yiliang , Xiao Jun 
Published: January 2024

AbstractAbscisic acid (ABA) is a crucial phytohormone involved in plant growth and stress responses. Although ABA has been implicated in the regulation of translation efficiency inArabidopsis thaliana, the underlying mechanism remains largely unknown. In this study, we discovered that ABA treatment modulates globally translation efficiency (TE) by affecting pre-rRNA processing in the nucleolus and ribosome distribution status in the cytoplasm. The regulation of TE by ABA was largely abolished in mutants of ABA signaling core components, such as receptors PYRABACTIN RESISTANCE1/PYRABACTIN-LIKE/REGULATORY COMPONENTS OF ABA RECEPTORS (PYR/PYL/RACRs), the protein phosphatase 2Cs (PP2Cs), and the SNF1-related protein kinase 2s (SnRK2s). ABA treatment reduced the protein levels of glycine-rich RNA binding protein 7 (GRP7) in the signaling core components-dependent manner. Ribo-seq and CLIP-seq analyses unveiled GRP7’s role in governing the TE of a substantial proportion of ABA-regulated genes, although independent of directly binding to the respective mRNAs. Furthermore, GRP7 directly bound to pre-rRNA and interacted with Ribosomal protein S6 (RPS6A), RPS14A and RPL36aA in the nucleolus to regulate rRNA processing. Additionally, GRP7 associated with mature polysome in the cytoplasm and is hypersensitive to translation inhibitor anisomycin when loss of function. Collectively, our study unveils the role of GRP7 in mediating translation regulation in ABA signaling, providing a novel regulatory model for plants to response to environmental stresses.
Beta2-Adrenergic Agonists in Treatment for Parkinsonism, with Implications for Neurodegenerative and Neoplastic Disorders
Authors: Inchiosa Mario A. 
Published: January 2024

AbstractThere is a long record of observations suggesting that β2-adrenergic agonists may have therapeutic value in Parkinson’s disease. Recent studies have focused on the possible role of β2-receptor agonists in suppressing the formation of α-synuclein protein, the component of Lewy bodies. Levalbuterol, the pure levo isomer of the β2 selective agonist, albuterol, has been found to possess significant anti-inflammatory activity, a property that may have the potential to suppress cytokine mediated degeneration of dopaminergic neurons and progression of Parkinsonism. All the β2 agonist and anti-inflammatory activities of albuterol reside in the levo isomer. The dextro isomer of albuterol substantially negates the efficacies of the levo form. Epinephrine, the prototypical β2 agonist and certain other adrenergic agents, when modeled in the Harvard/MIT Broad Institute genomic database, CLUE, demonstrated strong associations with the gene-expression signatures of drugs possessing glucocorticoid receptor agonist activity. Gene-expression signatures generated by the interaction of the adrenergic drugs of interest in 8 human tumor cell lines were compared with the entire CLUE database of more than 8,000 agents. The signatures were summarized for their consistency (connectivity) across all 8 cell lines and ranked for their relative degree of similarity to the agents in the database. Possible associations with anti-inflammatory activity of glucocorticoids promptedin vivobiological confirmation for levalbuterol and related agonists in the Jackson Laboratory human peripheral blood mononuclear cell (PBMC)-engrafted mouse. Levalbuterol inhibited the release of the eosinophil attractant chemokine, eotaxin-1 (specifically, CCL11), when the mice were challenged with mononuclear antibodies known to provoke cytokine release. Eotaxin is implicated in CNS and peripheral inflammatory disorders. Also, elaboration of the broad tumor-promoting angiogenic factor, VEGFa, and the pro-inflammatory cytokine, IL-13, from activated PBMCs were also inhibited by levalbuterol. These observations suggest possible translation to Parkinson’s disease, other neurodegenerative syndromes, and malignancies, by several mechanisms.
Annexin A1, Calreticulin and High Mobility Group Box 1 are elevated in Secondary Progressive Multiple Sclerosis: Does Immunogenic Cell Death Occur in Multiple Sclerosis?
Authors: Hejazi Mohammad Saeid , Jafari Sevda , Montazersaheb Soheila , Molavi Ommoleila , Hoseini Vahid , Talebi Mahnaz , Nikanfar Masoud 
Published: January 2024

AbstractMultiple sclerosis (MS) is a chronic neuroinflammatory diseases characterized by demyelination of the nerve fibers. Immunogenic cell death (ICD) is a process, during which damaged and stressed cells release danger-associated molecular patterns (DAMPs) activating immune responses. This study aimed to elucidate the induction of ICD in MS diseases. To achieve this goal, the level of DAMPs including Annexin A1, calreticulin and HMGB1 was measured in the cerebrospinal fluid (CSF) of a secondary progressive multiple sclerosis (SPMS) patient in comparison to control group. Results showed significant upregulation (more than two- fold) of Annexin A1, calreticulin and HMGB1 in the CSF of the patient. Although further studies are suggested in this regard, this data could imply induction of ICD in MS. The proposed ICD might trigger immune response against neural cells resulting in neuroinflammation and demyelination in CNS in MS. Our observation could suggest inclusion of ICD interfering treatments in routine MS therapy.
Early pancreatic tissue necrosis diagnoses by perfusion CT; the study K-Pa
Authors: Herpe Guillaume , Renaud Claire , Tasu Jean-Pierre 
Published: January 2024

ABSTRACTPURPOSEAcute pancreatitis (AP) is associated with high mortality and morbidity rates in case of necrotic forms. Risk assessment should be early performed to stratify patients into higher- and lower-risk of severe form to assist triage. In severe pancreatitis, capillary permeability increases, thereby contributing to capillary leakage which explains organ failures and or tissue necrosis. The aim of this study was therefore to evaluate pancreatic permeability by perfusion CT (pCT).METHODSFrom March 2018 to November 2018, patients with suspected AP and who underwent CT at admission were prospectively included. AP cases were classified according to the revised Atlanta classification. A permeability parameter, called k-trans, was measured from pCT in 3 pancreatic areas (normal parenchyma zone, defined by an area of normal CT pattern, pathological zone, defined as an area of parenchymal enlargement and or lack of enhancement and an intermediary zone defined by an area between normal and pathological areas) by to two observers. K-trans values in necrotic and interstitial forms for each zone were compared. To estimate reproducibility of the measure, inter-observer and intra-observer agreement was evaluated by a Bland and Altman test.RESULTS15 patients were enrolled (mean age 45.50 years old, +/-17.70). Four acute pancreatitis were necrotic, and 11 interstitial.Mean k-trans in pathologic zone of necrotic forms was significantly lower (mean=0.08) than in interstitial (mean=0.53), p= 0.0003. In both forms, k-trans values were significantly lower in pathologic zones than in intermediary and normal zones and the higher k-trans values were obtained in intermediary zones. Intra-observer reproducibility was good. Inter-observer reproducibility was acceptable, one bias was reported, close to zero (−0.052) with limited statistic difference.CONCLUSIONK-trans parameter, a well-known marker of tissue permeability, can be estimated by pCT. This parameter seems to be linked to local necrosis and could be used as a discriminant mean to diagnose necrotic from interstitial types of AP in the early phase of disease.
Blood transcriptomics reveal persistent SARS-CoV-2 RNA and candidate biomarkers in Long COVID patients
Authors: Menezes Soraya Maria , Jamoulle Marc , Carletto Maria Paula , Moens Leen , Meyts Isabelle , Maes Piet , Van Weyenbergh Johan 
Published: January 2024

AbstractWith an estimated 65 million individuals suffering from Long COVID, validated therapeutic strategies as well as non-invasive biomarkers are direly needed to guide clinical management. We used blood digital transcriptomics in search of viral persistence and Long COVID diagnostic biomarkers in a real-world, general practice-based setting with a long clinical follow-up. We demonstrate systemic SARS-CoV-2 persistence for more than 2 years after acute COVID-19 infection. A 2-gene biomarker, includingFYNand SARS-CoV-2 antisense RNA, correctly classifies Long COVID with 93.8% sensitivity and 91.7% specificity. Specific immune transcripts and immunometabolism score correlate to systemic viral load and patient-reported anxiety/depression, providing mechanistic links as well as therapeutic targets to tackle Long COVID.
Clonal haematopoiesis is associated with major adverse cardiovascular events in patients with hypertrophic cardiomyopathy
Authors: Scolari Fernando L. , Brahmbhatt Darshan , Abelson Sagi , Lee Deacon , Kim Raymond H , Pedarzadeh Ali , Sakhnini Ali , Adler Arnon , Chan Raymond H , Dick John , Rakowski Harry , Billia Filio 
Published: January 2024

ABSTRACTBackground & AimsThe heterogeneous phenotype of hypertrophic cardiomyopathy (HCM) is still not fully understood. Clonal haematopoiesis (CH) is emerging as a cardiovascular risk factor potentially associated with adverse clinical events. The prevalence, phenotype and outcomes related to CH in HCM patients was evaluated.MethodsPatients with HCM and available biospecimens from the Peter Munk Cardiac Centre Cardiovascular Biobank were subjected to targeted sequencing for 35 myeloid genes associated with CH. CH prevalence, clinical characteristics, morphological phenotypes assessed by echocardiogram and cardiac magnetic resonance and outcomes were assessed. All patients were evaluated for a 71-plex cytokines/chemokines, troponin I and B-type natriuretic peptide analysis. Major cardiovascular events (MACE) were defined as appropriate ICD shock, stroke, cardiac arrest, orthotopic heart transplant and death.ResultsAmong the 799 patients, CH was found in 183 (22.9%) HCM patients with sarcomeric germline mutations. HCM patients with CH were more symptomatic and with a higher burden of fibrosis than those without CH. CH was associated with MACE in those HCM patients with sarcomeric germline mutations [adjusted HR of 3.46 (95% CI 1.25-9.52; p=0.016)], with the highest risk among those that hadDNMT3A, TET2andASXL1mutations [adjusted HR of 7.23 (95% CI 1.79-29.13) p=0.005]. Several cytokines (IL-1ra, IL-6, IL-17F, TGFa, CCL21, CCL1, CCL8, and CCL17), and troponin I were upregulated in gene-positive HCM patients with CH.ConclusionsThese results indicate that CH in patients with HCM is associated with worse clinical outcomes. In the absence of CH, gene-positive patients with HCM have lower rates of MACE.KEY POINTSQuestionDoes clonal haematopoiesis (CH) affect the phenotype and outcomes among hypertrophic cardiomyopathy (HCM) patients?FindingsAmong 799 patients, CH was found in 183 (22.9%) HCM patients. CH was associated with symptoms, a higher burden of fibrosis and major cardiovascular events. Several cytokines and troponin I were upregulated in gene-positive HCM patients with CH.MeaningCH helps to identify those HCM patients at risk for serious adverse events and unveils a potential inflammatory response mechanism that affects prognosis.
Evaluation of Clonal Hematopoiesis and Mosaic Loss of Y Chromosome in Cardiovascular Risk: an analysis in prospective studies
Authors: Fawaz S , Marti S , Dufossée M , Pucheu Y , Gaufroy A , Broitman J , Bidet A , Soumaré A , Munsch G , Tzourio C , Debette S , Trégouët DA , James C , Mansier O , Couffinhal T 
Published: January 2024

AbstractBackgroundClonal hematopoiesis of indeterminate potential (CHIP) was initially linked to a twofold increase in atherothrombotic events. However, recent investigations have revealed a more nuanced picture, suggesting that CHIP may confer only a modest rise in Myocardial Infarction (MI) risk. This observed lower risk might be influenced by yet unidentified factors that modulate the pathological effects of CHIP. Mosaic loss of Y chromosome (mLOY), a common marker of clonal hematopoiesis in men, has emerged as a potential candidate for modulating cardiovascular risk associated with CHIP. In this study, we aimed to ascertain the risk linked to each somatic mutation or mLOY and explore whether mLOY could exert an influence on the cardiovascular risk associated with CHIP.MethodsWe conducted an examination for the presence of CHIP and mLOY using targeted high-throughput sequencing and digital PCR in a cohort of 446 individuals. Among them, 149 patients from the CHAth study had experienced a first myocardial infarction (MI) at the time of inclusion (MI(+) subjects), while 297 individuals from the Three-City cohort had no history of cardiovascular events (CVE) at the time of inclusion (MI(-) subjects). All subjects underwent thorough cardiovascular phenotyping, including a direct assessment of atherosclerotic burden. Our investigation aimed to determine whether mLOY could modulate inflammation, atherosclerosis burden, and atherothrombotic risk associated with CHIP.ResultsCHIP and mLOY were detected with a substantial prevalence (45.1% and 37.7%, respectively), and their occurrence was similar between MI(+) and MI(-) subjects. Notably, nearly 40% of CHIP(+) male subjects also exhibited mLOY. Interestingly, neither CHIP nor mLOY independently resulted in significant increases in plasma hsCRP levels, atherosclerotic burden, or MI incidence. Moreover, mLOY did not amplify or diminish inflammation, atherosclerosis, or MI incidence among CHIP(+) male subjects. Conversely, in MI(-) male subjects, CHIP heightened the risk of MI over a five-year period, particularly in those lacking mLOY.ConclusionOur study highlights the high prevalence of CHIP and mLOY in elderly individuals. Importantly, our results demonstrate that neither CHIP nor mLOY in isolation substantially contribute to inflammation, atherosclerosis, or MI incidence. Furthermore, we find that mLOY does not exert a significant influence on the modulation of inflammation, atherosclerosis burden, or atherothrombotic risk associated with CHIP. However, CHIP may accelerate the occurrence of MI, especially when unaccompanied by mLOY. These findings underscore the complexity of the interplay between CHIP, mLOY, and cardiovascular risk, suggesting that large-scale studies with thousands more patients may be necessary to elucidate subtle correlations.