bluuebunny/crossref_metadata_2025_split huggingface dataset:
Diagnosis of Perinatal Mental Health Conditions Following Medicaid Expansion to Include Low-Income Immigrants
Authors: Rodriguez Maria I. , Martinez-Acevedo Ann , Kaufman Menolly , Nacev Erin C. , Mackiewicz-Seghete Kristen , McConnell K. John 
Published: February 2024

ImportanceFor some low-income people, access to care during pregnancy is not guaranteed through Medicaid, based on their immigration status. While states have the option to extend Emergency Medicaid coverage for prenatal and postpartum care, many states have not expanded coverage.ObjectiveTo determine whether receipt of first prenatal care services and subsequently receipt of postpartum care through extensions of Emergency Medicaid coverage were associated with increases in diagnosis and treatment of perinatal mental health conditions.Design, Setting, and ParticipantsThis cohort study used linked Medicaid claims and birth certificate data from 2010 to 2020 with a difference-in-difference design to compare the rollout of first prenatal care coverage in 2013 and then postpartum services in Oregon in 2018 with a comparison state, South Carolina, which did not cover prenatal or postpartum care as part of Emergency Medicaid and only covered emergent conditions and obstetric hospital admissions. Medicaid claims and birth certificate data were linked by Medicaid identification number prior to receipt by the study team. Participants included recipients of Emergency Medicaid who gave birth in Oregon or South Carolina. Data were analyzed from April 1 to October 15, 2023.ExposureMedicaid coverage of prenatal care and Medicaid coverage of postpartum care.Main Outcomes and MeasuresThe main outcome was the diagnosis of a perinatal mental health condition within 60 days postpartum. Secondary outcomes included treatment of a mood disorder with medication or talk therapy.ResultsThe study sample included 43 889 births to Emergency Medicaid recipients who were mainly aged 20 to 34 years (32 895 individuals [75.0%]), multiparous (33 887 individuals [77.2%]), and living in metropolitan areas (32 464 individuals [74.0%]). Following Oregon’s policy change to offer prenatal coverage to pregnant individuals through Emergency Medicaid, there was a significant increase in diagnosis frequency (4.1 [95% CI, 1.7-6.5] percentage points) and a significant difference between states in treatment for perinatal mental health conditions (27.3 [95% CI, 13.2-41.4] percentage points). Postpartum Medicaid coverage (in addition to prenatal Medicaid coverage) was associated with an increase of 2.6 (95% CI, 0.6-4.6) percentage points in any mental health condition being diagnosed, but there was no statistically significant difference in receipt of mental health treatment.Conclusions and RelevanceThese findings suggest that changing Emergency Medicaid policy to include coverage for prenatal and 60 days of postpartum care for immigrants is foundational to improving maternal mental health. Expanded postpartum coverage length, or culturally competent interventions, may be needed to optimize receipt of postpartum treatment.
Adverse Immunological Reactions to Drugs
Authors: Ardern‐Jones Michael R. 
Published: February 2024

Abstract
Cutaneous eruptions caused by drug hypersensitivity reactions have been the subject of great interest to dermatologists for more than half a century. The precise molecular pathways involved in their pathogenesis are becoming clearer but there remain many areas that are poorly understood. Close delineation of the mechanistic pathways has been possible for some reactions including those where a close association with a specific human leukocyte antigen (HLA) type has been demonstrated. This work was led by the discovery that abacavir directly binds the HLA‐B*5701 major histocompatibility complex (MHC) peptide groove thereby altering the repertoire of self‐peptides that can be expressed in the MHC. Such novel self‐peptides are targeted T cells, which results in cytokine inflammation and induces clinical features typical of a drug hypersensitivity syndrome. HLA associations with severe cutaneous adverse reactions have now been shown for many different drugs. Despite the initial enthusiasm of this approach, it has become apparent that some drug–HLA associations have a lower odds ratio than others. This underscores the interpretation that other individual factors are at play as well as HLA sequence. Indeed, drug/HLA/clinical phenotype do not always correlate. For example, carbamazepine hypersensitivity is associated with both HLA‐B*1502 and HLA‐A*3101, yet genetic studies show that the former only predisposes to Stevens–Johnson syndrome (SJS)/toxic epidermal necrolysis (TEN) although the latter associates with exanthems, systemic hypersensitivity and SJS/TEN. In TEN, multiple molecular mechanisms of keratinocyte death have been postulated but two predominate including: (i) FasL upregulation and induction of Fas‐mediated keratinocyte cell death; and (ii) cytotoxic granulysin production by T, natural killer (NK) and NKT cells. Whether these act independently or synergistically remains to be established.
The TILOS AI Institute: Integrating optimization and AI for chip design, networks, and robotics
Authors: Kahng Andrew B. , Mazumdar Arya , Reeves Jodi , Wang Yusu 
Published: February 2024

AbstractOptimization is a universal quest, reflecting the basic human need to do better. Improved optimizations of energy‐efficiency, safety, robustness, and other criteria in engineered systems would bring incalculable societal benefits. But, fundamental challenges of scale and complexity keep many such real‐world optimization needs beyond reach. This article describes The Institute for Learning‐enabled Optimization at Scale (TILOS), an NSF AI Research Institute for Advances in Optimization that aims to overcome these challenges in three high‐stakes use domains: chip design, communication networks, and contextual robotics. TILOS integrates foundational research, translation, education, and broader impacts toward a new nexus of optimization, AI, and data‐driven learning. We summarize central challenges, early progress, and futures for the institute.
Simultaneous High Charge‐Spin Conversion Efficiency and Large Spin Diffusion Length in Altermagnetic RuO2
Authors: Zhang Yichi , Bai Hua , Han Lei , Chen Chong , Zhou Yongjian , Back Christian H. , Pan Feng , Wang Yuyan , Song Cheng 
Published: February 2024

AbstractEfficient spin sources with large spin Hall angle (θSH) and long spin diffusion length (λSD) are highly desired in the application of spintronic devices. However, due to strong spin‐orbit coupling, the two targets can hardly be achieved simultaneously in conventional relativistic spin sources, like heavy metals. Here, it is proven that collinear antiferromagnetic RuO2 films are able to address this key issue and break the inverse relationship of θSH versus λSD. Based on spin torque‐ferromagnetic resonance and spin pumping measurements, the authors demonstrate that the θSH of RuO2(100) films is 0.183, and the λSD is over 12 nm being an order of magnitude longer than that of Pt, β‐W, and β‐Ta. Meanwhile, sizable λSD is also obtained in spin current with out‐of‐plane spin polarization generated by RuO2(101) films. By conducting a control experiment, the nonrelativistic altermagnetic spin splitting effect (ASSE) is ascertained to be the crucial mechanism accounting for the simultaneous large θSH and long λSD in RuO2. Besides the fundamental significance, these findings will advance the development of spintronics towards higher efficiency and lower power consumption.
Regulating Interparticle Proximity in Plasmonic Nanosphere Aggregates to Enhance Photoacoustic Response and Photothermal Stability
Authors: Kim Myeongsoo , Kubelick Kelsey P. , Yu Anthony M. , VanderLaan Don , Jhunjhunwala Anamik , Nikolai Robert J. , Cadena Melissa , Kim Jinhwan , Emelianov Stanislav Y. 
Published: February 2024

AbstractDesigning plasmonic nanoparticles for biomedical photoacoustic (PA) imaging involves tailoring material properties at the nanometer scale. A key in developing plasmonic PA contrast nanoagents is to engineer their enhanced optical responses in the near‐infrared wavelength range, as well as heat transfer properties and photostability. This study introduces anisotropic plasmonic nanosphere aggregates with close interparticle proximity as photostable and efficient contrast agents for PA imaging. Silver (Ag) is particularly attractive because it has the strongest optical response and highest heat conductivity among plasmonic metals. The results demonstrate that close interparticle proximity in silver nanoaggregates (AgNAs), spatially confined within a polymer shell layer, leads to blackbody‐like optical absorption, resulting in robust PA signals through efficient pulsed heat generation and transfer. Additionally, the AgNAs exhibit a high photodamage threshold highlighting their potential to outperform conventional plasmonic contrast agents for high‐contrast PA imaging over multiple imaging sessions. Furthermore, the capability of the AgNAs are demonstrated for molecular PA cancer imaging in vivo by incorporating a tumor‐targeting peptide moiety.
Antibacterial Defective‐ZIF‐8/PPY/BC‐Based Flexible Electronics as Stress‐Strain and NO2 Gas Sensors
Authors: Men Ying , Qin Ziyu , Yang Zhou , Zhang Pengcheng , Li Mengting , Wang Qingji , Zeng Dawen , Yin Xueqiong , Ji Hongbing 
Published: February 2024

AbstractIntelligent wearable sensors play a crucial role in the detection of toxic gases and monitoring physiological signals, thereby effectively ensuring environmental and personal health safety. Nonetheless, achieving the requirements for antibacterial properties, comfortable wear, and multifunctional detection remains a major challenge. In this study, a novel Def‐ZIF‐8/PPY/BC‐based flexible sensor is developed by in situ growth of zeolitic imidazolate frameworks‐8 (ZIF‐8) and polypyrrole (PPY) on bacterial cellulose (BC), followed by water immersion. The Def‐ZIF‐8/PPY/BC‐based flexible sensor demonstrates effective dual‐sensitivity responses to nitrogen dioxide (NO2) toxic gas and stress‐strain behaviors at room temperature. The structural characterization and theoretical calculations affirm that the innovative water treatment method successfully introduces defects into ZIF‐8, resulting in a significant 2.57‐fold improvement in response intensity to 80 ppm NO2. Stress‐strain sensing performance analysis reveals that the Def‐ZIF‐8/PPY/BC‐based flexible sensor exhibited high sensitivity (6.44 kPa−1), rapid response and recovery times (0.7/0.4 s), and exceptional cyclic stability (8000 cycles). Further, the inhibitory effect of ZIF‐8 on common bacterial strains contributes to the exceptional antibacterial properties (antibacterial rate exceeding 99%) of the Def‐ZIF‐8/PPY/BC based on the flexible sensor. This study offers a significant advancement in metal‐organic framework defect engineering and provides an effective strategy for developing multifunctional wearable sensors.
Recent Developments of Carbon Dots for Advanced Zinc‐Based Batteries: A Review
Authors: Yi Mingguang , Jing Mingjun , Yang Yingchang , Huang Yujie , Zou Guoqiang , Wu Tianjing , Hou Hongshuai , Ji Xiaobo 
Published: February 2024

AbstractRechargeable Zn‐based batteries provide a compelling supplement to subsistent energy storage devices owing to their high energy density, good safety, and low cost. Nevertheless, inherent imperfections such as dendrite growth, side reactions, and andante reaction kinetics, severely impede their commercialization. As new 0D nanomaterials, carbon dots (CDs) with unique characteristics and excellent electrochemical activity, exhibit promising potential exploitation in electrochemistry and electrocatalysis areas. Herein, the adhibition of CDs in resolving the aforementioned drawbacks of Zn‐based batteries is introduced. To begin with, concepts, physicochemical properties, and synthetic methods of CDs are discussed. Next, recent developments and advances exploiting CDs in respectively ameliorating the performance of the Zn anode, the cathode, and electrolytes of Zn ion batteries and bifunctional electrocatalytic activities including oxygen reduction reaction and oxygen evolution reaction for Zn‐air batteries, are roundly reviewed and minutely generalized. Finally, current challenges and prospects are surveyed as well, aiming to offer a reference for the blossom of advanced Zn‐based batteries.
Deterministic Single‐Cell Encapsulation in PEG Norbornene Microgels for Promoting Anti‐Inflammatory Response and Therapeutic Delivery of Mesenchymal Stromal Cells
Authors: Si Hangjun , Chen Yuanzhuo , Jiang Kun , Ma Ke , Ramsey Edward , Oakey John , Sun Mingming , Jiang Zhongliang 
Published: February 2024

AbstractTissue engineering at single‐cell resolution has enhanced therapeutic efficacy. Droplet microfluidics offers a powerful platform that allows deterministic single‐cell encapsulation into aqueous droplets, yet the direct encapsulation of cells into microgels remains challenging. Here, the design of a microfluidic device that is capable of single‐cell encapsulation within polyethylene glycol norbornene (PEGNB) hydrogels on‐chip is reported. Cells are first ordered in media within a straight microchannel via inertial focusing, followed by the introduction of PEGNB solution from two separate, converging channels. Droplets are thoroughly mixed by passage through a serpentine channel, and microgels are formed by photo‐photopolymerization. This platform uniquely enables both single‐cell encapsulation and excellent cell viability post‐photo‐polymerization. More than 90% of singly encapsulated mesenchymal stromal cells (MSCs) remain alive for 7 days. Notably, singly encapsulated MSCs have elevated expression levels in genes that code anti‐inflammatory cytokines, for example, IL‐10 and TGF‐β, thus enhancing the secretion of proteins of interest. Following injection into a mouse model with induced inflammation, singly encapsulated MSCs show a strong retention rate in vivo, reduce overall inflammation, and mitigate liver damage. These translational results indicate that deterministic single‐cell encapsulation could find use in a broad spectrum of tissue engineering applications.
High Performance Stretchable Wire Li‐Ion Batteries
Authors: Muniraj Vedi Kuyil Azhagan , Delattre Roger , Saadaoui Mohamed , Calmes Cyril , Kurbatov Andrey Petrovitch , Kaupbay Olzhas , Malchik Fyodor , Djenizian Thierry 
Published: February 2024

AbstractThe development of integrated micro‐power sources is mainly driven by innovative investigations in materials chemistry, battery designs, and microfabrication processes. Here, a new technique is described for the development of coaxial wire‐shaped Li‐ion batteries by successfully adopting the unidirectional helical winding method starting from a twisted Cu fabric. Such a coaxial wire battery is examined by scanning electron microscopy and characterized by electrochemical techniques. These investigations reveal that the proposed approach is definitely suitable for achieving wire batteries showing high energy storage capacity while being highly flexible and stretchable without compromising the whole electrochemical performance even under mechanical deformations. The full cell based on the Li4Ti5O12/LiCoO2 system delivers an outstanding linear capacity of 137 µAh cm−1 at a 0.1C rate with nearly 100% coulombic efficiency and is further capable of being operated at various kinetics. It is also shown that such a coaxial wire battery can be used to power different electronic devices, which is of significance for the development of autonomous wearable applications like electronic textiles
Agri‐food trade liberalization, export prices, and quality upgrading: Evidence from the meat and chocolate sectors in OECD countries
Authors: Valea Aristide Bonsdaouêndé , Tamini Lota D. , Rousselière Damien 
Published: February 2024

AbstractThis article examines the impact of trade liberalization on export prices and quality. The article is innovative in two respects. First, unlike previous studies, it considers both input and output tariffs simultaneously in a theoretical model. Second, it empirically tests the effects of a combination of specific and ad‐valorem tariffs on quality improvement. The theoretical analysis suggests that when firms face reduced output and input tariffs, they tend to improve their export quality and increase export prices. Using export data from 33 OECD countries, the empirical analysis demonstrates that output tariff reduction increases export quality but decreases prices. However, the effects of input tariff reduction on price and quality depend on product differentiation. The results also indicate that the presence of specific tariffs increase product quality while amplifying the positive effects of the reduction of ad‐valorem tariffs on quality. This implies that to improve export quality, reducing ad‐valorem tariffs is more efficient than a specific tariff. [EconLit Citations: F12, F14, Q17].
Liquid–liquid mass transfer and pressure drop behavior in micro‐packed beds with different shaped packings
Authors: Zhang Jingwei , Zhang Xiaohui , Xu Jianhong , Chen Zhuo 
Published: February 2024

AbstractIn this work, the liquid–liquid two‐phase pressure drop and mass transfer characteristics in micro‐packed beds with different shaped packing are investigated. The experimental results show that the liquid–liquid mass transfer performance of micro‐packed bed is significantly affected by both apparent flow rates and phase ratio. By changing the characteristic size of the micro‐packed bed, the experimental results show that the average volume mass transfer coefficient has no obvious correlation with the length of the bed, which indicates that the flow and dispersion behavior along the length of the micro‐packed bed is basically stable. By considering dispersion strengthening, vortex strengthening and size effect, a semi‐empirical model for predicting liquid–liquid mass transfer performance in a micro‐packed bed is established for the first time. The model is in good agreement with the experimental results and has strong applicability to various shaped packings. In addition, by considering the contribution of inertia force, viscous force and interfacial tension to energy dissipation, a semi‐empirical model of liquid–liquid two‐phase pressure drop in a micro‐packed bed is established. The pressure drop prediction model can also be applied to different shaped packings.
Genetic relatedness can alter the strength of plant–soil interactions
Authors: Clark Kelly M. , Gallagher Marci J. , Canam Thomas , Meiners Scott J. 
Published: February 2024

AbstractPremiseIntraspecific variation may play a key role in shaping the relationships between plants and their interactions with soil microbial communities. The soil microbes of individual plants can generate intraspecific variation in the responsiveness of the plant offspring, yet have been much less studied. To address this need, we explored how the relatedness of seedlings from established clones of Solidago altissima altered the plant–soil interactions of the seedlings.MethodsSeedlings of known parentage were generated from a series of 24 clones grown in a common garden. Seedlings from these crosses were inoculated with soils from maternal, paternal, or unrelated clones and their performance compared to sterilized control inocula.ResultsWe found that soil inocula influenced by S. altissima clones had an overall negative effect on seedling biomass. Furthermore, seedlings inoculated with maternal or paternal soils tended to experience larger negative effects than seedlings inoculated with unrelated soils. However, there was much variation among individual crosses, with not all responding to relatedness.ConclusionsOur data argue that genetic relatedness to the plant from which the soil microbial inoculum was obtained may cause differential impacts on establishing seedlings, encouraging the regeneration of non‐kin adjacent to established clones. Such intraspecific variation represents a potentially important source of heterogeneity in plant–soil microbe interactions with implications for maintaining population genetic diversity.
Six‐week low‐molecular‐weight heparin versus 12‐week warfarin for calf deep vein thrombosis: A randomized, prospective, open‐label study
Authors: Sartori Michelangelo , Iotti Matteo , Camporese Giuseppe , Siragusa Sergio , Imberti Davide , Bucherini Eugenio , Corradini Sara , Ageno Walter , Prandoni Paolo , Ghirarduzzi Angelo 
Published: February 2024

AbstractCurrent guidelines suggest a 3‐month anticoagulant treatment course for isolated distal deep vein thrombosis (IDDVT), but shorter durations of treatment are frequently prescribed in clinical practice. We investigated whether a 6‐week treatment with low‐molecular‐weight heparin (LMWH) at intermediate dosage can be an effective and safe alternative to vitamin K antagonists (VKA) in patients with IDDVT (non‐inferiority trial). In a multicenter, open‐label, randomized trial, 260 outpatients with symptomatic IDDVT were randomly assigned to receive either LMWH followed by VKA for 12 weeks or LMWH 1 mg/kg subcutaneously twice a day for 2 weeks followed by 1 mg/kg subcutaneously once a day for 4 weeks. The follow‐up was 6 months and the primary endpoint was the composite measure of recurrent venous thromboembolism (VTE) defined as: recurrence or extension of IDDVT, proximal DVT, and pulmonary embolism (PE). The study was stopped prematurely due to slow recruiting rates. The primary efficacy outcome occurred in 14 patients receiving LMWH (10.8%) and in five patients receiving VKA (3.8%); risk difference was 0.069 (95% CI: 0.006–0.132), hazard ratio 2.8 (95% CI: 1.04–7.55). There was one PE in the VKA group and one proximal DVT in the LMWH group. IDDVT recurrence was 10.0% in the LMWH group versus 3.1% in the VKA group (p = .024). Two patients had clinically relevant bleedings (1.6%) in the LMWH group versus one (0.8%) in VKA group (p = .56). In conclusion, VKA for 12 weeks seems superior to LMWH for 6 weeks in reducing the risk of VTE recurrences in our cohort of outpatients with IDDVT.
Pyrrole‐Thiazolidin‐4‐one Analogues Exhibit Promising Anti‐Tuberculosis Activity
Authors: Ahmed Shujauddin , Mital Alka , Akhir Abdul , Saxena Deepanshi , Jahan Kousar , Dubey Gurudutt , Bharatam P. V. , Dasgupta Arunava , Chopra Sidharth , Jain Rahul 
Published: February 2024

AbstractA series of pyrrole‐thiazolidin‐4‐one conjugates were synthesized and evaluated for their anti‐mycobacterial and anti‐bacterial activities. Two compounds, 10 a and 10 k, were the most effective conjugates and produced identical MICs (0.5 μg/mL) against M. tuberculosis H37Rv with a high selectivity index. Upon evaluation against the ESKAP bacteria panel, compound 10 g emerged most effective against S. aureus (MIC=8.0 μg/mL) while compound 10 o produced activity against A. baumannii (MIC=4.0 μg/mL). A molecular docking study revealed that the most active compound 10 a has similar binding interactions as those of BM212 and rimonabant, with a comparable docking score against M. tuberculosis mycolic acid transporter MmpL3.