bluuebunny/crossref_metadata_2025_split huggingface dataset:
The impacts of patient mistreatment on healthcare workers’ role behaviors: a study in Chinese Fangcang shelter hospitals
Authors: Yan Wei , Bao Na , Zheng Shuangjiang , Wang Huan , Yue Dongmei , Chen Li 
Published: November 2023

Abstract
Background
Fangcang shelter hospitals have played an important role in the battle against the COVID-19 epidemic in China. Patients’ verbal and physical attacks on medical workforce are prone to occur in such hospitals. This study explored the impacts of patient mistreatment on healthcare workers’ role behaviors (service performance and patient-oriented organizational citizenship behavior).

Methods
We examined the influence of patient mistreatment on service performance and patient-oriented organizational citizenship behavior, as well as the mediating effect of emotional exhaustion and the moderating effect of displaced aggression by patients, using hierarchical linear regression and conditional process analysis.

Results
Patient mistreatment was positively associated with emotional exhaustion among healthcare workers, while emotional exhaustion was negatively associated with service performance and patient-oriented organizational citizenship behavior. Mediation analysis revealed that emotional exhaustion mediated the association between patient mistreatment and both types of role behaviors. Moderated mediation analysis found that the mediation effect was weaker when the displaced aggression by patients was high.

Conclusions
The findings clarified the relationship among patient mistreatment, emotional exhaustion, service performance, and patient-oriented organizational citizenship behavior. Additional assistance should be provided to healthcare workers dealing with patient mistreatment. Displaced aggression by patients attenuates the positive effects of patient mistreatment on the emotional exhaustion of healthcare workers. Our findings reveal the mechanism and boundary conditions of patient mistreatment affecting healthcare workers' service performance and patient-oriented organizational citizenship behavior.
Incorporation of L-Carnitine in the OvSynch protocol enhances the morphometrical and hemodynamic parameters of the ovarian structures and uterus in ewes under summer climatic conditions
Authors: Samir Haney , Swelum Ayman A. , Abdelnaby Elshymaa A. , El-Sherbiny Hossam R. 
Published: November 2023

AbstractHeat stress negatively impacts the reproductive performance of sheep including the efficiency of estrous synchronization regimens. This study aimed to investigate the potential effects of L-Carnitine (LC) administration on the efficacy of the OvSynch protocol in ewes under summer climatic conditions. Ewes were synchronized for estrus using the OvSynch protocol and a dose of LC (20 mg/kg body weight) was intravenously (IV) administered on the same day of PGF2α injection to one group (n = 8; LC group), while other ewes (n = 8; control group) received the same protocol without LC. Ultrasonographic evaluation (including B-mode, color, and pulsed Doppler) was used to assess the morphometrical and hemodynamic parameters of ovarian structures [number, size, and blood flow of follicles (GFs) and corpora lutea (CLs)] and uterus during the estrous phase (Day 0), and on Day 8 post ovulation (luteal phase). Uterine artery blood flow (MUA) was assessed by measuring the resistive index (RI) and pulsatility index (PI) at both stages. The serum samples were collected to measure the concentrations of estradiol (E2), progesterone (P4), and total antioxidant capacity (TAC) using commercial kits. Results revealed a significant (P<0.05) increase in the colored pixel area of GFs and uterus in the LC group (392.84 ± 31.86 and 712.50 ± 46.88, respectively) compared to the control one (226.25 ± 17.74 and 322 ± 18.78, respectively) during Day 0. Circulating E2 and TAC levels were significantly (P<0.05) higher in the LC-treated ewes (31.45 ± 1.53 pg/ml and 1.80 ± 0.13 mM/L, respectively) compared to those in the control ewes (21.20 ± 1.30 pg/ml and 0.98 ± 0.09 mM/L, respectively) during Day 0. Moreover, LC improved the colored pixel area of CLs (2038.14 ± 102.94 versus 1098 ± 82.39) and uterus (256.38 ± 39.28 versus 121.75 ± 11.36) and circulating P4 (2.99 ± 0.26 ng/ml versus1.67 ± 0.15 ng/ml) on Day 8. Values of RI of MUA were significantly lower in the LC group compared to the control one on Day 0 and Day 8 (0.48 ± 0.03 versus 0.72 ± 0.03 and 0.58 ± 0.03 versus 0.78 ± 0.02, respectively). In conclusion, LC incorporation in the OvSynch protocol enhanced the morphometrical and hemodynamic parameters of the ovarian structures and the uterus concomitantly with improvements in the TAC, E2, and P4 concentrations in ewes under hot summer conditions.
Neutralization of extracellular histones by sodium-Β-O-methyl cellobioside sulfate in septic shock
Authors: Garcia Bruno , Su Fuhong , Dewachter Laurence , Wang Yong , Li Ning , Remmelink Myriam , Eycken Marie Van , Khaldi Amina , Favory Raphaël , Herpain Antoine , Moreau Anthony , Moiroux-Sahraoui Alexander , Manicone Francesca , Annoni Filippo , Shi Lin , Vincent Jean-Louis , Creteur Jacques , Taccone Fabio S. 
Published: November 2023

Abstract
Background
Extracellular histones have been associated with severity and outcome in sepsis. The aim of the present study was to assess the effects of sodium-β-O-Methyl cellobioside sulfate (mCBS), a histone-neutralizing polyanion, on the severity and outcome of sepsis in an experimental model.

Methods
This randomized placebo-controlled experimental study was performed in 24 mechanically ventilated female sheep. Sepsis was induced by fecal peritonitis. Animals were randomized to three groups: control, early treatment, and late treatment (n = 8 each). mCBS was given as a bolus (1 mg/kg) followed by a continuous infusion (1 mg/kg/h) just after sepsis induction in the early treatment group, and 4 h later in the late treatment group. Fluid administration and antimicrobial therapy were initiated 4 h T4 after feces injection, peritoneal lavage performed, and a norepinephrine infusion titrated to maintain mean arterial pressure (MAP) between 65–75 mmHg. The experiment was blinded and lasted maximum 24 h.

Results
During the first 4 h, MAP remained > 65 mmHg in the early treatment group but decreased significantly in the others (p < 0.01 for interaction, median value at T4: (79 [70–90] mmHg for early treatment, 57 [70–90] mmHg for late treatment, and 55 [49–60] mmHg for the control group). mCBS-treated animals required significantly less norepinephrine to maintain MAP than controls (p < 0.01 for interaction) and had lower creatinine (p < 0.01), lactate (p < 0.01), and interleukin-6 (p < 0.01) levels, associated with reduced changes in H3.1 nucleosome levels (p = 0.02). Early treatment was associated with lower norepinephrine requirements than later treatment. Two control animals died; all the mCBS-treated animals survived.

Conclusions
Neutralization of extracellular histones with mCBS was associated with reduced norepinephrine requirements, improved tissue perfusion, less renal dysfunction, and lower circulating IL-6 in experimental septic shock and may represent a new therapeutic approach to be tested in clinical trials.
Does listening to audiobooks affect gait behavior?
Authors: Atakanova Aisuluu , Laurentius Thea , Bollheimer Cornelius , Hildebrand Frank , Siebers Hannah Lena 
Published: November 2023

Abstract
Background
The effect of listening to audiobooks, podcasts, and other audio files while walking on gait performance has not been well studied. Although the number of audio users is growing annually. Evidence suggests that a posture-first strategy contributes to gait stability in healthy individuals during dual-task conditions, but this effect may be diminished when the cognitive task is consciously prioritized. Objectives: To study the effect of listening to an audiobook while walking, as a daily life-like dual-task, on spatiotemporal gait parameters.

Methods
Forty young healthy (24.05 ± 3.66) subjects participated in the study. Spatiotemporal gait parameters were measured for 5 min on a treadmill once without (single-task) and once while listening to an audiobook through over-ear headphones (dual-task). Measured parameters included spatiotemporal parameters, gait phases, maximum pressure, and dual-task cost. Data were statistically analyzed using SPSS software.

Results
There were no significant differences in any of the studied parameters between the single- and dual-task conditions, even though the subjective cognitive load of listening to audiobooks while walking was high. However, participants with different habits had significant differences in gait phases and maximum pressure. Rare listeners had a shorter stance phase, a longer swing phase, and a higher maximum pressure on the dominant heel. They also had significant differences in dual-task costs.

Conclusion
No differences in the spatiotemporal gait parameters for walking with and without listening to audiobooks, as a daily life-like dual-task, were observed. However, the difference between participants who listened rarely and participants who listened often may confirm the “posture first” strategy in young healthy people.

Trial registration
DRKS00025837, retrospectively registered on 23.11.2021.
Diagnostic accuracy of multiparametric ultrasound in the diagnosis of prostate cancer: systematic review and meta-analysis
Authors: Tang Yun , Li Xingsheng , Jiang Qing , Zhai Lingyun 
Published: November 2023

Abstract
Objectives
Ultrasound (US) technology has recently made advances that have led to the development of modalities including elastography and contrast-enhanced ultrasound. The use of different US modalities in combination may increase the accuracy of PCa diagnosis. This study aims to assess the diagnostic accuracy of multiparametric ultrasound (mpUS) in the PCa diagnosis.

Methods
Through September 2023, we searched through Cochrane CENTRAL, PubMed, Embase, Scopus, Web of Science, ClinicalTrial.gov, and Google Scholar for relevant studies. We used standard methods recommended for meta-analyses of diagnostic evaluation. We plot the SROC curve, which stands for summary receiver operating characteristic. To determine how confounding factors affected the results, meta-regression analysis was used.

Results
Finally, 1004 patients from 8 studies that were included in this research were examined. The diagnostic odds ratio for PCa was 20 (95% confidence interval (CI), 8–49) and the pooled estimates of mpUS for diagnosis were as follows: sensitivity, 0.88 (95% CI, 0.81–0.93); specificity, 0.72 (95% CI, 0.59–0.83); positive predictive value, 0.75 (95% CI, 0.63–0.87); and negative predictive value, 0.82 (95% CI, 0.71–0.93). The area under the SROC curve was 0.89 (95% CI, 0.86–0.92). There was a significant heterogeneity among the studies (p < 0.01). According to meta-regression, both the sensitivity and specificity of mpUS in the diagnosis of clinically significant PCa (csPCa) were inferior to any PCa.

Conclusion
The diagnostic accuracy of mpUS in the diagnosis of PCa is moderate, but the accuracy in the diagnosis of csPCa is significantly lower than any PCa. More relevant research is needed in the future.

Critical relevance statement
This study provides urologists and sonographers with useful data by summarizing the accuracy of multiparametric ultrasound in the detection of prostate cancer.

Key points
• Recent studies focused on the role of multiparametric ultrasound in the diagnosis of prostate cancer.
• This meta-analysis revealed that multiparametric ultrasound has moderate diagnostic accuracy for prostate cancer.
• The diagnostic accuracy of multiparametric ultrasound in the diagnosis of clinically significant prostate cancer is significantly lower than any prostate cancer.

Graphical Abstract
Intensive antibiotic treatment of sows with parenteral crystalline ceftiofur and tulathromycin alters the composition of the nasal microbiota of their offspring
Authors: Bonillo-Lopez Laura , Obregon-Gutierrez Pau , Huerta Eva , Correa-Fiz Florencia , Sibila Marina , Aragon Virginia 
Published: November 2023

AbstractThe nasal microbiota plays an important role in animal health and the use of antibiotics is a major factor that influences its composition. Here, we studied the consequences of an intensive antibiotic treatment, applied to sows and/or their offspring, on the piglets’ nasal microbiota. Four pregnant sows were treated with crystalline ceftiofur and tulathromycin (CTsows) while two other sows received only crystalline ceftiofur (Csows). Sow treatments were performed at D-4 (four days pre-farrowing), D3, D10 and D17 for ceftiofur and D-3, D4 and D11 for tulathromycin. Half of the piglets born to CTsows were treated at D1 with ceftiofur. Nasal swabs were taken from piglets at 22–24 days of age and bacterial load and nasal microbiota composition were defined by 16 s rRNA gene qPCR and amplicon sequencing. Antibiotic treatment of sows reduced their nasal bacterial load, as well as in their offspring, indicating a reduced bacterial transmission from the dams. In addition, nasal microbiota composition of the piglets exhibited signs of dysbiosis, showing unusual taxa. The addition of tulathromycin to the ceftiofur treatment seemed to enhance the deleterious effect on the microbiota diversity by diminishing some bacteria commonly found in the piglets’ nasal cavity, such as Glaesserella, Streptococcus, Prevotella, Staphylococcus and several members of the Ruminococcaceae and Lachnospiraceae families. On the other hand, the additional treatment of piglets with ceftiofur resulted in no further effect beyond the treatment of the sows. Altogether, these results suggest that intensive antibiotic treatments of sows, especially the double antibiotic treatment, disrupt the nasal microbiota of their offspring and highlight the importance of sow-to-piglet microbiota transmission.
The effect of using virtual reality technology on anxiety and vital signs before surgery in patients undergoing open heart surgery
Authors: Amiri Ameneh , Jalali Rostam , Salari Nader 
Published: November 2023

Abstract
Introduction
Preoperative anxiety is one of the most common psychological problems in open-heart surgery patients. Not controlling this problem can negatively the operation outcome and the patient’s physical condition. Among various training methods and tools introduced to deal with this issue, the ideal method still remains unknown. Therefore, the present study was to determine the effect of using virtual reality technology on preoperative anxiety in patients undergoing open heart surgery.

Materials and methods
The participants of this interventional-educational study included 60 patients who were candidates for open heart surgery. The samples were randomly divided into two groups virtual reality(n = 30)and ordinary video (n = 30). For the virtual reality group, a virtual reality film and for the ordinary video group, an ordinary video of the physical space and operating room staff were displayed the day before the operation. Patients’ anxiety in both groups was assessed using the Spielberger State-Trait Anxiety Inventory (STAI) before and after the intervention. Data analysis was performed using the SPSS software version 25.

Results
The mean anxiety score before the intervention was 55.8 and 58.33 in the virtual reality group and the ordinary video group, respectively. After the intervention, it reached 38.60 in the virtual reality group and 45.13 in the control group. There was no statistically significant difference between the anxiety scores of the subjects in the virtual reality and ordinary video groups before the intervention (p > 0.05). However, the difference between the anxiety scores of the subjects in the virtual reality and ordinary video groups after the intervention was significant (p < 0.05).

Conclusion
Although virtual reality and ordinary video interventions effectively reduce anxiety in heart surgery patients, virtual reality seems to lower anxiety in heart surgery patients by diverting attention from external stimuli and immersing the person in the virtual world more than ordinary video.
Distribution of helminth eggs in environmental and stool samples of farming households along Akaki River in Addis Ababa, Ethiopia
Authors: Gurmassa Bethlhem kinfu , Gari Sirak Robele , Solomon Ephrem Tefera , Goodson Michaela L. , Walsh Claire L. , Dessie Bitew K. , Alemu Bezatu Mengistie 
Published: November 2023

Abstract
Background
Helminth infections are a public health issue in countries with poor sanitation facilities. However, there little information on the epidemiological association between helminths in wastewater and soil samples and rates of helminth infection among farming households along the Akaki River in Addis Ababa, Ethiopia.

Methods
A cross-sectional study was conducted between November 2021 and February 2022. A stratified random sampling technique was used to select farming households. The sample size for each district was determined by a proportionate allocation to the number of households. From wastewater-irrigated farms, 70 wastewater samples, 28 soil samples, and 86 farmers' stool samples were collected and analyzed for helminths. A questionnaire was used to gather ethnographic data, about farming households, whereas wastewater and soil sample analysis was used to generate quantitative data on helminth loads. The data were systematically analysed by developing themes, and bias evaluated using triangulation validation methodologies. Potential pathways to helminth infection were evaluated by measuring. Total number of helminth eggs in wastewater, soil samples and farmer's stools was investigated using Poisson regression.

Results
In this study, 82.9% of wastewater samples, 57.1% of soil samples, and 18.6% of farmers' stool samples contained helminth eggs. The most prevalent helminth was Ascaris lumbricoides in all samples (wastewater 67%, soil 25%, and stool 10.5%), followed by hookworm (wastewater 10%, soil 21.4%, and stool 6.9%) and Trichuris trichiura eggs (wastewater 5.7%, soil 10.7%, and stool 1.2%). There was a positive association between the total number of helminth eggs in wastewater and soil samples with counts in farmers’ stool. The Poisson regression coefficients for wastewater and soil were, 1.63 (95% CI = 1.34–1.92) and 1.70 (95% CI = 1.39–2.01), (p < 0.05).

Conclusions
This research has shown a clear association between the total helminth eggs in wastewater and soil samples and farmer stools along the Akaki River. Therefore, an integrated approach is essential to address the issue in this area and prevent the spread of further helminth infections.
Checkpoint Inhibitor-Associated Autoimmune Diabetes Mellitus Is Characterized by C-peptide Loss and Pancreatic Atrophy
Authors: Wu Linda , Carlino Matteo Salvatore , Brown David Alexander , Long Georgina Venetia , Clifton-Bligh Roderick , Mellor Rhiannon , Moore Krystal , Sasson Sarah Christina , Menzies Alexander Maxwell , Tsang Venessa , Gunton Jenny Elizabeth 
Published: November 2023

Abstract

Objective
To conduct a multicenter case series characterizing the clinical characteristics at presentation and pancreatic volume changes of patients with checkpoint inhibitor-associated autoimmune diabetes (CIADM).

Research Design and Methods
Electronic medical records were reviewed with 36 consecutive patients identified with CIADM, as defined by (1) previous immune checkpoint inhibitor (ICI) therapy, (2) new-onset hyperglycemia (blood glucose level ≥ 11.1 mmol/L and/or glycosylated hemoglobin ≥ 6.5%), and (3) insulin deficiency [C-peptide &lt;0.4 nmol/L or diabetic ketoacidosis (DKA)] within 1 month of presentation. Pancreatic volume was available and measured using computed tomography volumetry for 17 patients with CIADM and 3 sets of control patients: 7 with ICI-related pancreatitis, 13 with asymptomatic ICI-related lipase elevation, and 11 ICI-treated controls for comparison.

Results
All patients had either anti-programmed cell death protein 1 or anti-programmed cell death ligand 1 therapy. Median time from ICI commencement to CIADM diagnosis was 15 weeks. At presentation, 25 (69%) had DKA, 27 (84%) had low C-peptide, and, by 1 month, 100% had low C-peptide. Traditional type 1 diabetes autoantibodies were positive in 15/35 (43%). Lipase was elevated in 13/27 (48%) at presentation. In 4 patients with longitudinal lipase testing, elevated levels peaked 1 month prior to CIADM diagnosis. Pancreatic volume was lower pre-ICI in CIADM patients compared with controls and demonstrated a mean decline of 41% from pretreatment to 6 months post-CIADM diagnosis.

Conclusion
Pronounced biochemical and radiologic changes occur during CIADM pathogenesis. Rapid loss of C-peptide is a distinct characteristic that can be used to aid diagnosis as autoantibodies are often negative.
Wizerunek energetyki wiatrowej i jej oddziaływania na społeczeństwo w świetle doniesień mediów regionalnych i lokalnych w Polsce
Authors: Bednarek-Szczepańska Maria 
Published: November 2023

The development of onshore wind energy in Poland has been accompanied by controversy over the location of specific power plants. This issue has become a frequent topic in local/regional media. The purpose of this article is to determine how wind energy was portrayed in these media and, more importantly, what kinds of social impacts were the subject of media reports. The framework for the study is the concept of social impact assessment – SIA (Vanclay, 1999, 2002). The analysis covers the period 2010–2022. Articles for the analysis were obtained from online editions of the local/regional press from seven provinces in northern and central Poland, characterised by the highest level of wind energy development in 2020. A total of 321 articles were obtained from 19 titles of regional/local media. The research showed that wind energy was presented most often as a source of conflict around investment locations, and economic impacts were the most frequently described group of impacts. Two main portrayals of wind energy clashed in the regional/local media: a source of economic benefits for local communities on the one hand and a source of noise and health problems on the other. The debate on wind energy has varied over time. During the period when the anti-wind movement was most active in Poland, negative effects were most strongly emphasised in the media, while after the adoption of the Wind Power Investment Act, the debate on wind power almost quietened down and the share of articles presenting a positive image of wind power increased.
Influence of obesity and overweight on the incidence of gastrointestinal tumors - a systematic review of the literature
Authors: Grad Sylwia , Jaremek Anna , Kępa Joanna , Kandefer Norbert , Wyszkowski Michał , Grabarczyk Aleksandra , Pawlak Anna , Gregorek Małgorzata , Gregorek Paweł 
Published: November 2023

Introduction: The percentage of the population struggling with the problem of obesity has been steadily increasing in recent years, both among adults and children. Obesity is a chronic disease resulting from a positive energy balance, which does not tend to disappear spontaneously. The etiology of obesity is multidimensional, it is caused by genetic, environmental and behavioral factors. As a result, excessive amounts of adipose tissue are deposited in the body, which leads to an increased risk of various systemic diseases, including cancers of the digestive system.
Aim of the study: This review aims to show the relationship between overweight and obesity and the increased incidence of gastrointestinal cancers.
Materials and methods: An analysis of previous works present in the PubMed database was performed, using the following keywords: obesity, overweight, obesity and cancer, cancer.
Results: The results of the presented publications show the presence of a positive correlation between overweight and obesity, especially abdominal and the occurrence of gastrointestinal cancers.