bluuebunny/crossref_metadata_2025_split huggingface dataset:
Protein tyrosine phosphatases as emerging targets for cancer immunotherapy
Authors: Qu Zihan , Dong Jiajun , Zhang Zhong‐Yin 
Published: December 2023

AbstractContemporary strategies in cancer immunotherapy, despite remarkable success, remain constrained by inherent limitations such as suboptimal patient responses, the emergence of drug resistance, and the manifestation of pronounced adverse effects. Consequently, the need for alternative strategies for immunotherapy becomes clear. Protein tyrosine phosphatases (PTPs) wield a pivotal regulatory influence over an array of essential cellular processes. Substantial research has underscored the potential in targeting PTPs to modulate the immune responses and/or regulate antigen presentation, thereby presenting a novel paradigm for cancer immunotherapy. In this review, we focus on recent advances in genetic and biological validation of several PTPs as emerging targets for immunotherapy. We also highlight recent development of small molecule inhibitors and degraders targeting these PTPs as novel cancer immunotherapeutic agents.
Inpatient treatment of acute diverticulitis between 2010 and 2021 – A German nationwide study about long‐term trends and effects of the SARS‐CoV‐2 pandemic
Authors: Decker Josua A. , Scheurig‐Münkler Christian , Luitjens Jan H. , Schwarz Florian , Kroencke Thomas , Bette Stefanie 
Published: December 2023

AbstractAimThe aims of this study were to analyse all hospitalizations for acute diverticulitis in Germany from 2010 to 2021 and to assess the effects of the first 2 years of the SARS‐CoV‐2 pandemic on hospitalizations for acute diverticulitis.MethodUsing data from the German Federal Statistical Office, we analysed fully anonymized healthcare data of hospitalizations and treatment regimens with acute diverticulitis as the main diagnosis between 2010 and 2021. Logistic regression analyses for in‐hospital mortality were performed.ResultsA total of 608,162 hospitalizations were included. While the number of hospitalizations constantly increased until 2019 (+52.4%), a relative decrease of 10.1% was observed between 2019 and 2020, followed by stable numbers of hospitalizations in 2021 (+1.1% compared with 2020). In‐hospital mortality showed a relative decrease of 33.2% until 2019 and thereafter a relative increase of 26.9% in 2020 and of 7.5% in 2021. A 21.6% and a 19.3% drop in hospitalizations was observed during the first and second waves of the SARS‐CoV‐2 pandemic, mostly affecting hospitalizations for uncomplicated diverticulitis, with a corresponding 11.6% and 16.8% increase in admissions for complicated diverticulitis. Multivariable logistic regression analyses showed significantly higher in‐hospital mortality for hospitalizations in which surgery (OR = 2.76) and CT (OR = 1.32) were given, as well as lower mortality for women (OR = 0.88), whereas percutaneous drainage was not associated with higher in‐hospital mortality compared with conservative treatment (OR = 0.71).ConclusionThis study points out the long‐term trends in inpatient treatment for acute diverticulitis and the in‐hospital mortality risk factors of patients hospitalized for acute diverticulitis in a large nationwide cohort, as well as changes in these trends and factors resulting from the SARS‐CoV‐2 pandemic. These changes might be attributable to delayed diagnosis and thus more severe stages of disease as a result of containment measures.
Risk of stroke within 3, 7, 14, 21 and 30 days after influenza vaccination in Alberta, Canada: A population‐based study
Authors: Tanaka Koji , Demchuk Andrew M. , Malo Shaun , Hill Michael D. , Holodinsky Jessalyn K. 
Published: December 2023

AbstractBackground and purposeInfluenza vaccination is associated with a longer‐term protective effect against stroke; however, it has a short‐term inflammatory response which may increase short‐term risk of stroke. The aim was to investigate the association between influenza vaccination and short‐term risk of stroke in adults.MethodsAdministrative data were obtained from the Alberta Health Care Insurance Plan for all adults in Alberta, Canada, from September 2009 to December 2018. The hazard of any stroke (acute ischaemic stroke, intracerebral haemorrhage, subarachnoid haemorrhage and transient ischaemic attack) within 3, 7, 14, 21 and 30 days of influenza vaccination compared to unexposed time was analysed using Andersen−Gill Cox models, with adjustment for age, sex, anticoagulant use, atrial fibrillation, chronic obstructive pulmonary disease, diabetes, hypertension, income quintile, and rural or urban home location.ResultsIn the entire cohort consisting of 4,141,209 adults (29,687,899 person‐years), 1,769,565 (42.7%) individuals received at least one vaccination. In total 38,126 stroke events were recorded with 1309 occurring within 30 days of a vaccination event. Influenza vaccination was associated with a significantly reduced hazard of stroke within 3 days (hazard ratio [HR] 0.83, 95% confidence interval [CI] 0.73–0.93), 7 days (HR 0.87, 95% CI 0.80–0.95), 14 days (HR 0.87, 95% CI 0.81–0.93), 21 days (HR 0.85, 95% CI 0.80–0.91) and 30 days (HR 0.66, 95% CI 0.65–0.68).ConclusionsAn increased early risk associated with vaccination was not observed. The risk of stroke was reduced at all time points within 30 days after influenza vaccination.
Sign here: Coresidence contracts for parents and young adults who live together
Authors: Wellsch Jordan , Gelech Jan , Mazurik Kathrina 
Published: December 2023

AbstractObjectiveTo describe the content of parent and young adult coresidence contracts, attending to understandings of development and adulthood, processes of socialization, and conflict prevention and resolution.BackgroundLittle is known about overcoming the challenges of parent and young adult coresidence. Popular media encourages families to adopt written contracts to clarify expectations, prevent conflict, and cultivate positive experiences. However, their content, use, and effectiveness have not been empirically investigated.MethodThis work is a qualitative content analysis of a sample of young adult and parent coresidence contracts obtained from popular self‐help and parenting resources.ResultsContract content emphasized the following: parent and young adult rights and responsibilities, timelines around the termination of coresidence and other responsibilities and developmental milestones, legal motifs, punishments and rewards, rationalizing commentary, and room for personalization. Overall, contracts focused on role‐specific rights and responsibilities and positioned young adults as subjects of socialization in hierarchical family systems.ConclusionCoresidence contracts scaffold young adult development according to traditional Western understandings of adulthood. Depending on family circumstances, they have the potential to benefit and harm parent–child relationships.ImplicationsThe asymmetrical nature of coresidence contacts raises questions about their ability to support mutual aims, intergenerational understanding, young adult independence, interpersonal trust, and healthy parent–young adult relationships.
Does negative news disclosure induce better decision‐making? Evidence from acquisitions
Authors: Ghosh Chinmoy , Pinto‐Gutiérrez Cristian , Shenoy Jaideep 
Published: December 2023

AbstractWe examine the effect of negative news disclosures on acquisition decisions of firms. Using textual analysis of company press releases, we find that the percentage of negative news disclosed by a firm reduces its probability of acquisitions. However, for firms that do undertake acquisitions, the percentage of negative news disclosed is positively related to announcement‐period abnormal returns. Consistent with theoretical predictions, this positive relationship is more pronounced for acquirers with low pay‐performance sensitivity and those operating in concentrated industries. Overall, our results suggest that when managerial reputation concerns are high following negative news development, they make more prudent acquisition decisions.
Association between dietary diversity and cognitive impairment in community‐dwelling older adults
Authors: Kiuchi Yuto , Doi Takehiko , Tsutsumimoto Kota , Nakakubo Sho , Kurita Satoshi , Nishimoto Kazuhei , Makizako Hyuma , Shimada Hiroyuki 
Published: December 2023

AimThe present study aimed to examine whether dietary diversity is associated with cognitive impairment, including mild cognitive impairment (MCI), in community‐dwelling older Japanese adults.MethodsThis cross‐sectional study was carried out in a general community setting. MCI and global cognitive impairment (GCI) were assessed using the Mini‐Mental State Examination and National Center for Geriatrics and Gerontology‐Functional Assessment Tool, which are multicomponent neurocognitive tests that include memory attention, executive function and processing speed. Dietary diversity was assessed using the diet variety score. The diet variety score assessed the 1‐week consumption frequency of 10 food groups, and either 0 or 1 point was allocated to each category based on the following responses: (i) “eat almost every day” (1 point); and (ii) “not eaten almost daily” (0 points). Older adults with a diet variety score of ≥3 points were defined as having high dietary diversity.ResultsData included 8987 older adults (mean age 73.9 ± 5.5 years; men 44.3%). The overall prevalences of MCI and GCI were 17.1% (n = 1538) and 8.4% (n = 753), respectively. The proportion of patients with a high dietary diversity was 69.9% (n = 6286). Multinomial logistic regression analysis revealed high dietary diversity was associated with MCI (OR 0.83, 95% CI 0.73–0.94) and GCI (OR 0.77, 95% CI 0.65–0.92) after adjusting for covariates.ConclusionsThis study had a large sample size of older Japanese adults, and showed that high dietary diversity was associated with a lower proportion of MCI and GCI among older adults. Geriatr Gerontol Int 2024; 24: 75–81.
Histologic manifestations of ocrelizumab‐associated intestinal and hepatic injury in patients with multiple sclerosis
Authors: Challa Bindu , Esnakula Ashwini Kumar 
Published: December 2023

AimsOcrelizumab is a humanized anti‐CD20‐monoclonal antibody that has recently been approved for the treatment of certain types of multiple sclerosis. Isolated case reports of ocrelizumab‐associated colitis have been reported in the literature. We present a case series of ocrelizumab‐associated intestinal injury with a focus on histopathologic features and report a case of ocrelizumab‐associated hepatitis.Methods and resultsA retrospective computerized search was conducted from 03/2017 to 08/2022, which identified six patients with suspected or clinically confirmed ocrelizumab‐associated intestinal injury and one patient with hepatic injury. Pertinent clinical, endoscopic, and histopathologic findings were reviewed and recorded. Seven patients (six female, one male) were identified with ages ranging from 24 to 68 years. The presenting symptoms included diarrhoea (n = 5), abdominal pain (n = 3), hematochezia (n = 2), and vomiting (n = 1), nausea (n = 1) fever (n = 1), and weight loss (n = 1). Endoscopic findings ranged from normal (n = 1) to patchy colonic inflammation with or without ulceration (n = 4) and decreased mucosal vascular pattern in the rectum (n = 1). Crohn's disease was clinically suspected in two patients and ulcerative colitis in one patient. None of the patients had a prior confirmed diagnosis of inflammatory bowel disease. Histologic patterns of initial colonic injury included acute colitis/proctitis (n = 5), and chronic active colitis (n = 1). Follow‐up ranged from 1 to 3 years and 10 months. All patients were alive at follow‐up. Follow‐up biopsies were available for four patients and findings included focal acute colitis (n = 1), apoptotic colopathy (n = 1) lymphocytic colitis (n = 1), and normal mucosa (n = 1). Four patients were treated with steroids and ocrelizumab was discontinued in three patients. Two patients were symptomatically managed with subsequent resolution of symptoms. The liver biopsy from the patient with a marked hepatic pattern of liver enzyme elevation showed an acute hepatitis pattern of injury with prominent centrilobular necrosis, which resolved upon discontinuation of the drug and treatment with steroids and azathioprine.ConclusionsThe histologic manifestations of ocrelizumab‐associated intestinal injury are variable and can mimic inflammatory bowel disease. Hepatic injury can rarely manifest as an acute hepatitis pattern of injury with necrosis. Identifying ocrelizumab‐associated injury is paramount in determining management, which often includes discontinuation of ocrelizumab therapy, and/or administration of immunosuppressive therapy.
Skin manifestations in adults with gender dysphoria on hormone treatment in the outpatient clinic of Hospital de San José, Bogotá—Colombia
Authors: Castañeda Manuel F. O. , Cortés Henry T. , Isaac Nicolle G. , Cárdenas Carolina M. 
Published: December 2023

AbstractBackgroundComprehensive healthcare for patients with gender dysphoria includes access to gender‐affirming hormone therapy. It may cause cutaneous and adnexal side effects, which often affect quality of life, are underdiagnosed, and do not receive timely treatment. The literature on this subject is scarce. The main objective was to identify skin manifestations secondary to hormone treatment in adults with gender dysphoria.MethodsObservational, descriptive, cross‐sectional study. A search was performed in the database of patients with gender dysphoria older than 18 years treated at the dermatology and/or endocrinology outpatient clinic of the Hospital de San José de Bogotá in the period 2015–2021. Medical records of patients on hormone therapy with skin manifestations were selected, while patients using other medications as possible triggers were excluded.ResultsIn total, 85 patients were included, with a predominance of young transgender men (average age was 27 ± 9 years) in whom the main manifestation was acne (87%), followed by androgenetic alopecia and acanthosis nigricans. Transgender women presented more acne, androgenetic alopecia, hypertrichosis, seborrheic dermatitis, and melasma. The majority received treatment, mainly topical therapies. More than half of the patients were treated by the endocrinology and dermatology services.ConclusionsSkin manifestations in patients with gender dysphoria on hormone therapy are frequent, so they should be known and taken into account in the multidisciplinary approach to these patients, which should involve dermatologists. This is the first Colombian and Latin American study focused on documenting skin manifestations in patients with gender dysphoria undergoing hormone therapy.
Metrological traceability in flow cytometry? Evaluation of a new volumetric method for lymphocyte subsets
Authors: Ward Rosalie Y. , Stevens Matthew , Bashir Sheriaz 
Published: December 2023

AbstractIntroductionLymphocyte subset enumeration by flow cytometry is important for the therapeutic monitoring of a range of conditions. However, current bead‐based methodologies do not produce metrologically traceable results. Here we compare an established bead‐based methodology with a volumetric‐based system traceable to an internationally recognised reference method.MethodA total of 118 samples received for lymphocyte subset analysis were tested using an established bead‐based technique (BD Multitest™ 6‐colour TBNK assay using Trucount™ tubes on a BD FACSLyric flow cytometer), followed by a volumetric method on the Sysmex XF‐1600 flow cytometer using Exbio Kombitest 6‐colour TBNK reagent. All samples were tested in accordance with the manufacturer's instructions.ResultsAbsolute count values from both methodologies for CD3+, CD3 + CD4+, CD3 + CD8+, CD19+ and CD3‐CD16+/CD56+ lymphocyte populations were compared using linear regression (R2 for all parameters >0.95) and Bland–Altman analysis. There was no significant bias (where p < 0.05) for absolute CD3 + CD4+ lymphocytes in the defined therapeutic range of 0–250 cells/μL (mean bias: 0.27 cells/μL). Although positive biases were seen for CD3 + CD4+ lymphocytes (over the entire range tested: 14–1798 cells/μL) and CD3‐CD16+/CD56+ lymphocytes (mean bias: 10.83 cells/μL and 6.79 cells/μL, respectively). Negative biases were seen for CD3 + CD8+ and CD19+ lymphocytes (mean bias: −29.17 cells/μL and − 18.76 cells/μL, respectively).ConclusionA high degree of correlation was found for results from both methodologies and observed bias was within the limits of clinical acceptability for all populations. This shows that the metrologically traceable lymphocyte subset absolute counts produced by the Sysmex XF‐1600 are robust within clinically required limits.
Global patterns of herbivorous eriophyoid mite species diversity: A reply to Ozman‐Sullivan and Sullivan (2024)
Authors: Li Ni , Xue Xiao‐Feng 
Published: December 2023

AbstractAimThe global patterns of phytophagous eriophyoid mite species diversity have been poorly studied for several decades. In a previous paper, we compiled a dataset covering 97% (4278/4400) of named eriophyoid mite species and 22,973 occurrence sites from 102 countries (Li et al., 2023). Using this dataset, we aimed to predict the global distribution patterns and species diversity of eriophyoid mites. Our findings revealed that the species richness of eriophyoid mites is particularly high in temperate regions, which is in contrast to the patterns of plants (Li et al., 2023). However, our results were criticized by Ozman‐Sullivan and Sullivan (2024), who argue that our analysis is based on a biased dataset of eriophyoid mites, because it is likely that there are many undescribed eriophyoid species in the tropics.LocationGlobal.TaxonEriophyoid mites (Acari: Eriophyoidea).Main ConclusionsHowever, using plant species to predict eriophyoid mite diversity, as Ozman‐Sullivan and Sullivan propose, may result in an overestimation of species richness. We leave ‘whether the species richness of eriophyid mites is high in tropical regions’ as an open question and a potential area for future research.
Whole‐transcriptome defines novel glucose metabolic subtypes in colorectal cancer
Authors: Li Shaohua , Fang Wei , Zheng Jianfeng , Peng Zhiqiang , Yu Biyue , Chen Chunhui , Zhang Yuting , Jiang Wenli , Yuan Shuhui , Zhang Lingqiang , Zhang Xueli 
Published: December 2023

AbstractColorectal cancer (CRC) is the most prevalent malignancy of the digestive system. Glucose metabolism plays a crucial role in CRC development. However, the heterogeneity of glucose metabolic patterns in CRC is not well characterized. Here, we classified CRC into specific glucose metabolic subtypes and identified the key regulators. 2228 carbohydrate metabolism‐related genes were screened out from the GeneCards database, 202 of them were identified as prognosis genes in the TCGA database. Based on the expression patterns of the 202 genes, three metabolic subtypes were obtained by the non‐negative matrix factorization clustering method. The C1 subtype had the worst survival outcome and was characterized with higher immune cell infiltration and more activation in extracellular matrix pathways than the other two subtypes. The C2 subtype was the most prevalent in CRC and was characterized by low immune cell infiltration. The C3 subtype had the smallest number of individuals and had a better prognosis, with higher levels of NRF2 and TP53 pathway expression. Secreted frizzled‐related protein 2 (SFRP2) and thrombospondin‐2 (THBS2) were confirmed as biomarkers for the C1 subtype. Their expression levels were elevated in high glucose condition, while their knockdown inhibited migration and invasion of HCT 116 cells. The analysis of therapeutic potential found that the C1 subtype was more sensitive to immune and PI3K‐Akt pathway inhibitors than the other subtypes. To sum up, this study revealed a novel glucose‐related CRC subtype, characterized by SFRP2 and THBS2, with poor prognosis but possible therapeutic benefits from immune and targeted therapies.
Higher cumulative dose of topical corticosteroids is associated with osteoporosis and major osteoporotic fracture: A nationwide case–control study
Authors: Hsieh Bing‐Jun , Shen Dereck , Chan Tom C. , Cho Yung‐Tsu , Tang Chao‐Hsiun , Chu Chia‐Yu 
Published: December 2023

AbstractBackgroundConnections between long‐term use of topical corticosteroids (TCSs) of varying potency and osteoporosis and major osteoporotic fracture (MOF) are unclear. Susceptibility to adverse bone effects of TCSs in different sex, age and ethnic groups is unknown too.ObjectivesTo demonstrate the association between cumulative dose of TCSs of varying potency and osteoporosis and MOF in Taiwanese population, with stratified analysis of sex and age.MethodsWe conducted a nationwide case–control study and obtained data from Taiwan National Health Insurance Research Database. Cumulative TCS doses in different exposure periods were calculated, and the potency of TCSs was converted to prednisolone equivalent. Adjusted odds ratios (ORs) with 95% confidence intervals (CIs) were calculated for osteoporosis and MOF associated with TCS use.ResultsFrom 2017 to 2020, 129,682 osteoporosis cases and 34,999 MOF cases were selected and randomly matched with 518,728 and 139,996 controls by sex and age. We found clear dose–response relationships between long‐term TCS exposure and osteoporosis and MOF. For example, compared to no TCS use, adjusted ORs of osteoporosis were 1.216 (95% CI 1.189–1.243), 1.260 (95% CI, 1.241–1.280) and 1.341 (95% CI, 1.314–1.369) for exposure to low, medium and high cumulative TCS doses, respectively, over 5 years. Adjusted ORs of MOF were 1.118 (95% CI 1.069–1.170), 1.191 (95% CI, 1.156–1.227) and 1.288 (95% CI, 1.238–1.340) for exposure to low, medium and high cumulative TCS doses, respectively, over 5 years. Stratified analysis showed women had higher ORs of osteoporosis and MOF compared to men. Younger people (<50 years) had highest OR of osteoporosis compared to other age groups.ConclusionsHigher cumulative TCS dose was associated with increased risk of osteoporosis and MOF. Long‐term use of TCSs should be cautious, especially in susceptible populations such as women and young people.
A new distinctively striped species of bushynose catfish (Siluriformes: Loricariidae: Ancistrus) from the Pachitea River drainage, Pasco, Peru
Authors: Neuhaus Emanuel Bruno , Meza‐Vargas Vanessa , Herrera Julio Ramírez , Lujan Nathan K. 
Published: December 2023

AbstractWith 76 currently valid species, the bushynose catfish genus Ancistrus is the fourth most species‐rich catfish genus, yet Ancistrus diversity remains underestimated, with many species still undescribed. This is especially true of the Peruvian Andean headwaters of the Amazon, which are rich in unnamed Ancistrus species but have received little recent taxonomic attention. We describe a distinctively striped new Ancistrus species from tributaries of the Palcazú River, in the Pachitea‐Ucayali‐Amazonas drainage basin. The new species differs from all congeners by having black, vermiculated lines covering the head and two to four distinct black, parallel, lateral body stripes from head to caudal fin (vs. body uniformly colored or with dark or light spots or blotches over head and body, or black vermiculate lines on flanks). The new species is the fifth valid species of Ancistrus described from the rich Ucayali River ichthyofauna. It has previously been recognized in the aquarium fish trade as L267.