bluuebunny/crossref_metadata_2025_split huggingface dataset:
Comprehensive Network and Structural Analysis of Bovine Papillomavirus, Squamous Cell Carcinoma Markers, and Elucidation of Efficacy Mechanisms of Phytochemicals fromThuja Occidentalis
Authors: Rahman Shafiqur , Kumar Arun HS 
Published: December 2023

AbstractPapillomaviruses infect cutaneous tissue in various species including bovines and from benign warts to malignant squamous cell carcinoma causing severe economic losses to the farmers. The mechanisms by which bovine papillomaviruses interact with host tissue are unclear. Hence in this study using classical network analysis tools, we evaluated interactions of Bovine papilloma (BPV) variants, with markers and receptors implicated in squamous cell carcinoma. Additionally, the thuja phytoconstituents were also evaluated for its potential to target the BPV and squamous cell carcinoma network interactions to understand the mechanism of its clinical benefits. Various protein composition of 14 different virus variants of BPV were assessed against 24 markers of squamous cell carcinoma. Among these interactions EGFR consistently exhibited high-affinity interactions with the E1 protein in all isoforms of BPV. Type 4 BPV displayed the maximum number of binding sites (14) with a binding pocket score ranging from 15.47 to 141.34 and a probability score of 0.75 to 0.99. The comparison of the binding pockets identified that BPV types 2 and 13 had the highest number of common amino acid sequences. Further the alpha helix structure of specific common amino acid sequences, contribute to a more robust and widespread affinity interaction with both E1 of various BPV types and EGFR. Analysis of thuja phytochemicals suggested superior efficacy of Beyerene and Terpinene-4-ol towards all ten BPV targets and bEGFR. In conclusion, our comprehensive study leading to identification of E1 protein of BPV as a major interacting network with bEGFR, their key binding sites, and efficacy of thuja phytoconstituents offer valuable insight into further experimental validation and development of novel therapeutic strategies against BPV-associated diseases.
ADrosophilamodel of mitochondrial disease phenotypic heterogeneity
Authors: Granat Lucy , Knorr Debbra Y. , Ranson Daniel C. , Chakrabarty Ram Prosad , Chandel Navdeep S. , Bateman Joseph M. 
Published: December 2023

AbstractMutations in genes that affect mitochondrial function cause primary mitochondrial diseases. Mitochondrial diseases are highly heterogeneous and even patients with the same mitochondrial disease can exhibit broad phenotypic heterogeneity, which is poorly understood. Mutations in subunits of mitochondrial respiratory complex I cause complex I deficiency, which can result in severe neurological symptoms and death in infancy. However, some complex I deficiency patients present with much milder symptoms. The most common nuclear gene mutated in complex I deficiency is the highly conserved core subunit NDUFS1. To model the phenotypic heterogeneity in complex I deficiency we used RNAi lines targeting theDrosophilaNDUFS1 homolog ND-75 with different efficiencies. Strong knockdown of ND-75 inDrosophilaneurons resulted in severe behavioural phenotypes, reduced lifespan, altered mitochondrial morphology, reduced endoplasmic reticulum (ER)-mitochondria contacts and activation of the unfolded protein response (UPR). By contrast, weak ND-75 knockdown caused much milder behavioural phenotypes and changes in mitochondrial morphology. Moreover, weak ND-75 did not alter ER-mitochondria contacts or activate the UPR. Weak and strong ND-75 knockdown resulted in overlapping but distinct transcriptional responses in the brain, with weak knockdown specifically affecting proteosome activity and immune response genes. Metabolism was also differentially affected by weak and strong ND-75 knockdown including gamma-aminobutyric acid (GABA) levels, which may contribute to neuronal dysfunction in ND-75 knockdown flies. Several metabolic processes were only affected by strong ND-75 knockdown including the pentose phosphate pathway and the metabolite 2-hydroxyglutarate (2-HG), suggesting 2-HG as a candidate biomarker of severe neurological mitochondrial disease. Thus, ourDrosophilamodel provides the means to dissect the mechanisms underlying phenotypic heterogeneity in mitochondrial disease.
Quantitative Modeling of the Short-Term Response to Nitrogen Availability that Coordinates Early Events in Lateral Root Initiation
Authors: Gaudinier Allison , Van den Broeck Lisa , Moreno-Risueño Miguel , Rodriguez-Medina Joel , Sozzani Rosangela , Brady Siobhan M. 
Published: December 2023

AbstractNitrogen (N) is an essential macronutrient and its bioavailability plays a major role in how plant development is tuned to environmental nutrient status. To find novel factors in early root system architecture responses to N conditions, we performedArabidopsis thalianaroot transcriptome profiling of a short-term time course in limiting and sufficient N conditions. Using this data, we inferred transcriptional regulatory networks in each condition, which revealed the N-condition specific responses of jasmonate regulation; transcriptional factor (TF) ERF107 plays a more generalized role in lateral root development while TF LBD13 is specific to N-limiting conditions. Further, we used a single cell LR cell-type specific transcriptome dataset to model and analyze the roles of TFs LBD13, ERF107, and PDF2 in early stages of LR development. Linking the N time course transcriptomics, LR mutant phenotypes, and cell-type specific single cell profiling, these approaches provide multiple lines of evidence to find and test the roles of TFs that are involved in early root patterning responses to N conditions.
Would an AI chatbot persuade you: an empirical answer from the elaboration likelihood model
Authors: Chen Qian , Yin Changqin , Gong Yeming 
Published: December 2023

PurposeThis study investigates how artificial intelligence (AI) chatbots persuade customers to accept their recommendations in the online shopping context.Design/methodology/approachDrawing on the elaboration likelihood model, this study establishes a research model to reveal the antecedents and internal mechanisms of customers' adoption of AI chatbot recommendations. The authors tested the model with survey data from 530 AI chatbot users.FindingsThe results show that in the AI chatbot recommendation adoption process, central and peripheral cues significantly affected a customer's intention to adopt an AI chatbot's recommendation, and a customer's cognitive and emotional trust in the AI chatbot mediated the relationships. Moreover, a customer's mind perception of the AI chatbot, including perceived agency and perceived experience, moderated the central and peripheral paths, respectively.Originality/valueThis study has theoretical and practical implications for AI chatbot designers and provides management insights for practitioners to enhance a customer's intention to adopt an AI chatbot's recommendation.Research highlightsThe study investigates customers' adoption of AI chatbots' recommendation.The authors develop research model based on ELM theory to reveal central and peripheral cues and paths.The central and peripheral cues are generalized according to cooperative principle theory.Central cues include recommendation reliability and accuracy, and peripheral cues include human-like empathy and recommendation choice.Central and peripheral cues affect customers' adoption to recommendation through trust in AI.Customers' mind perception positively moderates the central and peripheral paths.
Revisiting the impact of consumers' need for touch on webrooming intention: the perspective of maximizing mindset theory
Authors: Hsieh Jung-Kuei , Kumar Sushant 
Published: December 2023

PurposeThe purpose of this paper addresses the issue of inconsistent findings regarding the impact of consumers' need for touch (NFT) on webrooming behavior. It investigates the moderator of maximization by drawing on maximizing mindset theory.Design/methodology/approachThree studies were carried out to test the hypothesized relationships. The first study investigated the impact of autotelic NFT on webrooming intention. The second study examined the impact of instrumental NFT on webrooming intention. The third study tested all hypotheses by the structural equation modeling approach.FindingsThe results confirm moderation by consumers' maximizing mindset. The moderated mediation analyses show that the interaction effect of autotelic NFT and maximization influences webrooming intention indirectly via anticipated sensory pleasure. Likewise, the interaction effect of instrumental NFT and maximization influences webrooming intention indirectly via product fit uncertainty.Originality/valueThe study draws on maximizing mindset theory to show that consumers' autotelic NFT and instrumental NFT drive their webrooming intentions depending on the activation of their maximizing mindset. The nonsignificant relationship between autotelic NFT and webrooming intention in the context of satisficers explains the conflicting findings reported in the literature. Consumers' affective and cognitive responses were also studied to uncover the underlying mechanisms of their webrooming intention. This research contributes to the literature by enhancing the understanding of webrooming behavior.
Vegetation composition regulates the interaction of warming and nitrogen deposition on net carbon dioxide uptake in a boreal peatland
Authors: Gong Yu , Wu Jianghua , Roulet Nigel , Le Thuong Ba , Ye Chen , Zhang Quanfa 
Published: December 2023

Abstract

Peatlands are carbon sinks and have the potential to mitigate global warming. However, it is unclear whether peatlands will remain carbon sinks or switch to carbon sources under global changes, such as climate warming, elevated nitrogen (N) deposition and vegetation composition change.

In this study, these global changes were mimicked in a boreal peatland for 7 years to explore the interactions of climate warming, elevated N deposition and vegetation composition on the carbon sink function of peatlands.

The results showed that warming has a limited effect on net ecosystem production (NEP), while N addition decreased NEP by 65% owing to the detrimental effect on Sphagnum mosses. The negative impact of N addition on NEP could be mitigated by warming under intact vegetation. Under the treatment of graminoid removal, warming and elevated N addition (WN) decreased NEP by 80%–106%. Under the treatment of shrub removal, 7 years of WN treatment did not affect NEP. These results highlight the importance of vegetation composition in regulating net CO2 flux in peatlands. If peatlands shift to shrub‐dominated ecosystems, the net CO2 uptake in peatlands would be decreased under climate warming and elevated N deposition. If peatlands shift to graminoid‐dominated ecosystems, the net CO2 uptake in peatlands would be unaltered under climate warming and elevated N deposition.

This study sheds new light on the interactions of climate warming, elevated N deposition, and vegetation composition change on the CO2 uptake of peatlands; and could help accurately evaluate the carbon sink function of peatlands under future global change.

Read the free Plain Language Summary for this article on the Journal blog.
The Impact of Credit Market Development on Auditor Choice: Evidence from Banking Deregulation
Authors: DE FRANCO GUS , GUAN YUYAN , ZHOU YIBIN , ZHU XINDONG 
Published: December 2023

ABSTRACTWe exploit the staggered state‐level adoption of the Riegle‐Neal Interstate Banking and Branching Efficiency Act (IBBEA) to examine how banking deregulation and the resulting increase in bank competition affect firms’ auditor choices. We find that an exogenous increase in the degree of interstate branch banking deregulation leads to a reduction in firms’ propensity to engage a Big N or industry expert auditor. This main result, when combined with our cross‐sectional analyses, offers evidence suggesting that deregulation leads to less demand for higher quality auditors because (1) firms have increased access to credit, which reduces the benefits of higher audit quality; (2) entering banks’ lending expertise substitutes for higher quality financial statements; (3) incumbent banks with less lending expertise seek to protect their rents by preferring that borrowers provide lower quality financial statement information; and (4) external stakeholders delegate their monitoring to banks to a greater degree, resulting in less demand for higher quality financial statements. As such, our study sheds light on how the U.S. credit market's infrastructure shapes firms’ auditor choice decisions.
Distinct karyotypic and mutational landscape in trisomy AML
Authors: Lam Stephen S. Y. , Tsui Sze P. , Fung C. Y. , Saw Nicole Y. , Javed Asif , Ip Alvin H. W. , Ma Edmond S. K. , Leung Anskar Y. H. 
Published: December 2023

SummaryTrisomy karyotype occurs in 5%–10% of AML. Its mutational landscape and prognostic significance are not well defined. A cohort of 156 trisomy AML patients was analysed, with reference to 615 cytogenetically normal (CN) AML patients. Trisomy AML showed distinct mutational landscape with more prevalent SMC1A, N/KRAS, ASXL1 and BCOR but fewer CEBPAbZIP and NPM1 mutations in patients ≤60, and fewer NPM1 mutations in those >60. NRAS mutations were associated with poor outcome in trisomy AML, whereas DNMT3A and FLT3‐ITD mutations had neutral effect. Trisomy AML appeared biologically distinct from CN‐AML.
What attachment scholars can learn from research on Black family resilience
Authors: Stern Jessica A. , Coard Stephanie Irby , Barbarin Oscar A. , Cassidy Jude 
Published: December 2023

AbstractWithin a sociohistorical context of racism‐related physical and emotional threats, Black families in the United States have developed sources of resilience to promote children's safety and positive development. Yet research on Black family resilience has rarely been integrated into one of the most influential theories of child development: attachment theory. In this article, we propose specific ways that attachment scholars can learn from research on Black family resilience to enrich models of parent–child relationships, focusing on three sources of resilience: culturally specific parental protections (e.g., “The Talk,” preparation for bias), extended caregiving networks (e.g., natural mentors, fictive kin, spiritual community), and racial‐ethnic identity development (e.g., racial pride messages to protect against social denigration). We argue that including insights from research on the resilience of Black children and families in the face of racism‐related threats across generations can substantially advance current understanding of caregiving, attachment, and positive child development in context.
Impact of rapid on‐site evaluation in expediting the fast investigative lung cancer pathway
Authors: Fowell Andrew , Khan Kashif 
Published: December 2023

AbstractObjectiveEBUS‐TBNA is a method of acquiring tissue samples from intrathoracic lymph nodes and central intrathoracic tumours in patients suspected of having lung cancer. Rapid on‐site evaluation (ROSE) denotes assessing tissue samples during EBUS (or bronchoscopy), providing instant feedback on sample adequacy and provisional cytomorphological diagnosis. Sector multidisciplinary team (MDT) discussion can then make informed treatment decisions, with confirmatory immunohistochemistry being finalised before provision of final treatment. Currently, impact of ROSE on length of time patients spend on the lung cancer diagnostic pathway remains unclear.MethodsWe retrospectively evaluated the impact of ROSE on the length of time between patients' EBUS/bronchoscopy procedures and discussion at sector MDT, referred to as time to treatment decision (TTD), at our institution. Additionally, we assessed impact of ROSE on number of passes (number of times nodes/masses were sampled) per procedure.ResultsThe mean TTD was 77.9% shorter (p = 0.001) with ROSE present than when absent. Patients who received ROSE spend 34.3% less time (p = 0.028) on lung cancer diagnostic pathway overall. There was a significant reduction in number of passes in non‐malignant nodes with ROSE present (2.23) than when absent (3.14) (p < 0.001). With ROSE present there was a significantly greater number of passes at malignant sites (5.07) than non‐malignant sites (2.23) (p < 0.001).ConclusionsThese findings support conclusions made in our institution's previous study, that utilisation of ROSE reduces TTD. ROSE also allows safe advancement through nodes with low suspicion of malignant involvement, focusing time on sampling nodes/masses of greater suspicion.
Non‐invasive markers of inflammation in alcohol‐associated liver disease: A scoping review
Authors: Fahoum Khalid , Ying Xiaohan , Magahis Patrick T , Ross Joshua , Basu Elora , Shen Nicole T , Baltich Nelson Becky , Brown Robert S , Jesudian Arun B 
Published: December 2023

AbstractClinical manifestations of liver inflammation in alcohol‐associated liver disease (ALD) can range from asymptomatic to severe alcoholic hepatitis. While biopsy is the gold standard for identifying liver inflammation, it is an invasive procedure with risks of bleeding, visceral damage, and infection. We aim to establish the state of the current literature on non‐invasive markers of inflammation in ALD. We searched Ovid MEDLINE, Embase, and the Cochrane Library for original studies on the association between one or more non‐invasive biomarker(s) and histological inflammation or hepatitis in ALD patients. Exclusion criteria were lack of histological data, abstract only, non‐English‐language articles, and animal studies. Two independent reviewers screened abstracts, reviewed full texts, and extracted data from included papers. Our search identified 8051 unique studies. Title and abstract screening resulted in 563 studies, and full‐text screening resulted in 31 studies for final inclusion. The majority were single‐center observational cohorts with an average sample size of 124. Review of these studies identified 44 unique biomarkers and 8 calculated scores associated with histological inflammation and/or hepatitis, in addition to a metabolomic panel of 468 metabolites. Six studies examined diagnostic accuracy for histological inflammation and/or hepatitis. The highest area under the receiver operating characteristic curve was 0.932 using a model based on four metabolites. This review highlights the available literature on non‐invasive markers of inflammation in ALD. There is a dearth of studies that evaluate the diagnostic accuracy of these biomarkers, and larger studies are needed to confirm findings identified in small cohorts.
Development and validation of a Chinese version chronic wound health‐related quality of life instrument: A methodological study
Authors: Hung Chang‐Chiao , Chen Chien‐Ming , Chang Ya‐Hui , Lee Shiao‐Haung , Chang Chia‐Hao , Chen Yea‐Jyh 
Published: December 2023

AbstractAims and ObjectivesTo develop a Chinese version of a chronic wound health‐related quality of life (QoL) instrument and to examine the psychometric properties of this instrument.BackgroundExisting QoL instruments are not tailored to the linguistic and cultural characteristics of Chinese‐speaking patients; a version addressing this gap will increase clinical understanding of their healthcare experience and may help guide chronic wound care.DesignA methodological study.MethodsThe method advanced by DeVellis (2017) was used to develop the instrument. An initial pool of 38 items was created. To optimize scale length and test reliability and validity, exploratory and confirmatory factor analyses were conducted. A total of 23 items formed the final pool. After two rounds of expert discussions, the average content validity index of the final 23 items was .89.ResultsA total of 226 patients completed the instrument and were divided into two groups for further analysis. Exploratory factor analysis revealed that 15 items remained in four factors (social activity restrictions, physical and psychological disturbance, wound burden and daily life limitation), which accounted for 64.87% of the variance. Confirmatory factor analysis revealed an acceptable fit of the hypothesized factor structure and the convergent and discriminant validities were achieved. Cronbach's α coefficients for each factor were .807, .773, .799 and .713, respectively.ConclusionThe Chinese version of a chronic wound health‐related QoL instrument consists of 15 items in four subscales and demonstrates good reliability and validity.Relevance to Clinical PracticeThis instrument can be used intermittently or continuously to evaluate the treatment effect of chronic wounds by assessing health‐related QoL. Scholars in Chinese‐speaking regions may find this culturally compatible instrument useful when conducting studies related to chronic wounds.Patient or Public ContributionTwo hundred twenty‐six participants provided their perspectives on health‐related QoL.
Effect of different preparation designs of minimally invasive occlusal onlays on the accuracy of different intraoral scanners: An in vitro study
Authors: Ashraf Khadija , Ebeid Kamal , Salah Tarek 
Published: December 2023

AbstractPurposeThe aim of this in vitro study was to assess and compare three different preparation designs of minimally invasive occlusal onlays on the trueness and precision of three different intraoral scanners under two different scanning conditions.Materials and MethodsThree maxillary premolars were prepared in three different designs and divided accordingly into three groups, Group 1: Anatomical (n = 60), Group 2: Flat (n = 60), and Group 3: Ferrule (n = 60). The samples were then further divided into subgroups according to scanners as subgroup A: Medit i500 (n = 20), subgroup B: 3Shape TRIOS 4 (n = 20), and subgroup C: Cerec Primescan (n = 20). Last, the samples were further divided according to scanning conditions: Division i: As prepared (n = 10) and Division ii: Sprayed – scan spray (n = 10). An industrial 3D scanner was used to obtain the reference STL files. Accuracy was assessed in terms of trueness and precision and recorded in terms of root mean square in micrometers. Numerical data were explored for normality using Shapiro‐Wilk test and were analyzed using 3‐way ANOVA followed by Tukey's post hoc test.ResultsRegarding trueness, 3‐way ANOVA showed that all tested variables had a significant effect on trueness. Significant interactions were found between the different variables (p < 0.001). For preparation design the highest value was found in ferrule preparation (27.88 ± 7.11), followed by flat preparation (22.99 ± 7.56), while the lowest value was found in anatomical preparation (18.83 ± 5.71) (p < 0.001). For scanner type, the highest value was found in Primescan (25.36 ± 10.66), followed by TRIOS 4 (22.75 ± 5.98), while the lowest value was found in Medit i500 (21.59 ± 5.03) (p < 0.001). As for the scanning condition, sprayed samples (26.54 ± 8.24) had a significantly higher value than non‐sprayed samples (19.93 ± 5.53) (p < 0.001). Regarding precision, both preparation design and scanner type had a significant effect on precision. Scanning conditions had no significant effect. There was a significant interaction between the three tested variables (p = 0.012).ConclusionsAnatomical preparation of minimally invasive occlusal onlays produced the most accurate scans. Within the tested preparation designs, Medit i500 and 3Shape TRIOS 4 have better trueness than Cerec Primescan. Cerec Primescan is more precise than 3Shape TRIOS 4 and Medit i500 Scan spray application causes a higher deviation in the trueness of the tested intraoral scanners while it does not affect their precision.