bluuebunny/crossref_metadata_2025_split huggingface dataset:
Usefulness of FDG‐PET to diagnose intravascular lymphomatosis presenting as fever of unknown origin
Authors: Hoshino A. , Kawada E. , Ukita T. , Itoh K. , Sakamoto H. , Fujita K. , Mantani N. , Kogure T. , Tamura J. 
Published: June 2004

AbstractIntravascular lymphomatosis (IVL) is a rare systemic disease characterized by proliferation of lymphoid cells within the lumina of small arteries, veins, and capillaries. Diagnosis requires skin, liver, lung, bone marrow, renal, meningeal, or brain vessel biopsy but is often made only when the illness has progressed or post mortem because early involvement of organs was not evident. We report a case of IVL presenting as fever of unknown origin (FUO). In this case, gallium scintigraphy and computed tomography (CT) showed no evidence of malignancy, whereas 18F‐fluorodeoxyglucose positron emission tomography (FDG‐PET) showed increased FDG uptake in the sternum, left and right vertebra, humerus, femur, and especially ilium. The diagnosis was made on iliac bone marrow biopsy examination. FDG‐PET was useful for the detection of spread of disease in a patient with IVL suffering from FUO. Am. J. Hematol. 76:236–239, 2004. © 2004 Wiley‐Liss, Inc.
Prospective screening of 205 patients with ITP, including diagnosis, serological markers, and the relationship between platelet counts, endogenous thrombopoietin, and circulating antithrombopoietin antibodies
Authors: Aledort Louis M. , Hayward Catherine P.M. , Chen Mon‐Gy , Nichol Janet L. , Bussel James 
Published: June 2004

AbstractImmune thrombocytopenia purpura (ITP) is characterized by destruction of circulating platelets and the presence of antiplatelet antibodies. Many of the current immunomodulatory therapies act by reducing platelet destruction and usually do not have a lasting effect. This prospective, exploratory study characterized patients with ITP by identifying their demographic and comorbid clinical factors, use of treatments, serologic markers of autoimmunity, and possible relationships between platelet counts, concentrations of endogenous thrombopoietin (eTPO), and the presence of circulating anti‐TPO antibodies. Data including medical history and laboratory evaluations were collected at a single patient visit on 205 patients (19 children, 186 adults). Reported histories revealed a 5% rate of thrombotic/ischemic events. Autoimmune markers including direct antiglobulin test and antinuclear antibodies were found more frequently than in the normal population; antiplatelet antibody testing was not done. eTPO concentrations were comparable to concentrations found in healthy volunteers. Our study confirmed that no significant inverse correlation occurred between circulating concentrations of eTPO and platelet counts in patients with ITP (Spearman r = −0.15). Two of the 205 patients tested (1%) had neutralizing activity of recombinant human TPO in a biological assay; however, this activity was confirmed to be anti‐TPO antibody in only 1 patient. Am. J. Hematol. 76:205–213, 2004. © 2004 Wiley‐Liss, Inc.
Vasoactive factors in sickle cell disease: In vitro evidence for endothelin‐1‐mediated vasoconstriction
Authors: Ergul Sitki , Brunson Chris Y. , Hutchinson Jim , Tawfik Amany , Kutlar Abdullah , Webb R. Clinton , Ergul Adviye 
Published: June 2004

AbstractWhile systemic plasma endothelin‐1 (ET‐1) levels are increased during acute crisis in sickle cell disease, the relative levels of potent vasoactive factors that contribute to the regulation of vascular function, such as ET‐1, NO, and cell‐free hemoglobin, during the course of periodic vaso‐occlusive episodes remain unclear. Moreover, whether and to what extent sickling‐induced release of ET‐1 alters vascular tone is not completely understood. To investigate the sequential changes in circulating vasoactive factors, we measured plasma ET‐1, NO metabolites (NOx), and cell‐free hemoglobin (Hb) before (steady‐state), during (crisis), and after a vaso‐occlusive (post‐crisis) episode. Steady‐state ET‐1 levels (fmol/mL) increased from 2.3 ± 0.4 to 11.0 ± 1.4 and 4.2 ± 1.0 during crisis and post‐crisis periods, respectively. There was no significant difference in plasma NOx levels. Cell‐free Hb levels were significantly higher in sickle cell patients in all phases as compared to the control group, and especially during crisis cell‐free Hb levels were elevated by 4‐fold (209,000 ± 31,000 vs. 46,000 ± 5,300 ng/mL in steady‐state). Conditioned medium from human pulmonary artery endothelial cells exposed to sickled erythrocytes prepared by deoxygenation induced contraction of aortic rings, and this effect was blocked by an ETA receptor antagonist. These findings indicate that ET‐1 is the predominant contractile factor released by cultured endothelial cells upon exposure to deoxygenated sickled SS erythrocytes and ET‐1–NO–NO scavenger balance is altered in favor of vasoconstriction during an acute episode in SCD. Am. J. Hematol. 76:245–251, 2004. © 2004 Wiley‐Liss, Inc.
Sweet's syndrome associated with sargramostim (granulocyte‐macrophage colony stimulating factor) treatment
Authors: Kumar Geetika , Bernstein Jack M. , Waibel Jill S. , Baumann Michael A. 
Published: June 2004

AbstractSweet's syndrome is an acute febrile neutrophilic dermatosis that is a known complication of the administration of filgrastim, a drug that causes increased neutrophil proliferation and differentiation. This complication has not previously been reported during treatment with sargramostim, a hematopoietic cytokine with activity that overlaps filgrastim. We report a case of Sweet's syndrome in association with sargramostim treatment following chemotherapy for acute myelogenous leukemia. A suspected second episode occurred after subsequent chemotherapy and sargramostim treatment. Physicians should be aware of this possible association because the signs and symptoms of Sweet's syndrome are easily mistaken as being due to infection. Am. J. Hematol. 76:283–285, 2004. © 2004 Wiley‐Liss, Inc.
Primary trabeculodysgenesis in association with neonatal Marfan syndrome
Authors: Whitelaw Charlotte M. , Anwar Samira , Adès Lesley C. , Gole Glen A. , Elder James E. , Savarirayan Ravi 
Published: June 2004

AbstractWe present the clinical and ophthalmological findings in two infants with neonatal Marfan syndrome (nMFS) and primary trabeculodysgenesis (PT). Fibrillin 1 (FBN1) mutations were confirmed in both cases. Numerous eye anomalies have been recognized in infants with nMFS, but PT has not been reported previously. Our report expands the phenotype of nMFS, and highlights the importance of early and careful ophthalmological assessment of these infants. © 2004 Wiley‐Liss, Inc.
Molecular characterization of a cryptic 2q37 deletion in a patient with Albright hereditary osteodystrophy‐like phenotype
Authors: Chassaing N. , De Mas P. , Tauber M. , Vincent M.C. , Julia S. , Bourrouillou G. , Calvas P. , Bieth E. 
Published: June 2004

AbstractThe Albright hereditary osteodystrophy‐like (AHO‐like) syndrome was recently defined as a rare dysmorphic syndrome including brachymetaphalangism and mental retardation. This phenotype occurs in Albright hereditary osteodystrophy (AHO) but unlike it, the level of the Gs alpha protein activity is not reduced. To date 59 patients with these clinical and biochemical features have been reported, and for the majority of them (57/59) a cytogenetically visible 2q37 deletion has been observed. We report a new case of typical AHO‐like syndrome with normal karyotype. Using the polymorphic marker D2S125 we found a loss of heterozygosity suggestive of a de novo 2q37 deletion of maternal origin. This hypothesis was confirmed by FISH analysis with a subtelomeric 2q probe containing the D2S90 marker. Genotypic analysis allowed us to map the proximal breakpoint of the subtelomeric deletion within an interval delimited by D2S2338 (present) and D2S2253 (deleted). This 2q subtelomeric deletion as small as 4 Mb is to date the smallest one observed in association with a typical AHO‐like phenotype, and allows us to move the centromeric boundary of the AHO‐like critical region by 750 kb towards the 2q telomere. © 2004 Wiley‐Liss, Inc.
Catalytic Markovnikov and anti‐Markovnikov Functionalization of Alkenes and Alkynes: Recent Developments and Trends
Authors: Beller Matthias , Seayad Jayasree , Tillack Annegret , Jiao Haijun 
Published: June 2004

AbstractThe regioselective functionalization of terminal alkenes and alkynes is of utmost importance for the synthesis of a wide variety of organic products. Based on the original observation by Vladimir Markovnikov—the pioneer of this field of research—in the 19th century, the possible regioisomeric products are classified as Markovnikov or anti‐Markovnikov products. Contrary to traditional belief, it is nowadays possible to control the regiochemistry of various additions of nucleophiles to alkenes and alkynes by applying different transition‐metal catalysts. Recent developments in this area of selective functionalization of alkenes and alkynes are reviewed.
Palladium Oxidase Catalysis: Selective Oxidation of Organic Chemicals by Direct Dioxygen‐Coupled Turnover
Authors: Stahl Shannon S. 
Published: June 2004

AbstractSelective aerobic oxidation of organic molecules is a fundamental and practical challenge in modern chemistry. Effective solutions to this problem must overcome the intrinsic reactivity and selectivity challenges posed by the chemistry of molecular oxygen, and they must find application in diverse classes of oxidation reactions. Palladium oxidase catalysis combines the versatility of PdII‐mediated oxidation of organic substrates with dioxygen‐coupled oxidation of the reduced palladium catalyst to enable a broad range of selective aerobic oxidation reactions. Recent developments revealed that cocatalysts (e.g. CuII, polyoxometalates, and benzoquinone) are not essential for efficient oxidation of Pd0 by molecular oxygen. Oxidatively stable ligands play an important role in these reactions by minimizing catalyst decomposition, promoting the direct reaction between palladium and dioxygen, modulating organic substrate reactivity and permitting asymmetric catalysis.
Effects of increased muscle mass on mouse sagittal suture morphology and mechanics
Authors: Byron Craig D. , Borke James , Yu Jack , Pashley David , Wingard Christopher J. , Hamrick Mark 
Published: June 2004

AbstractThe purpose of this study is to test predicted form–function relationships between cranial suture complexity and masticatory muscle mass and biomechanics in a mouse model. Specifically, to test the hypothesis that increased masticatory muscle mass increases sagittal suture complexity, we measured the fractal dimension (FD), temporalis mass, and temporalis bite force in myostatin‐deficient (GDF8−/−) mice and wild‐type CD‐1 mice (all male, 6 months old). Myostatin is a negative regulator of muscle mass, and myostatin‐deficient mice show a marked increase in muscle mass compared to normal mice. We predicted that increased sagittal suture complexity would decrease suture stiffness. The data presented here demonstrate that increased suture complexity (measured as FD) was observed in a hypermuscular mouse model (GDF8−/−) with significantly increased temporalis muscle mass and bite forces. Hypermuscular mice were also found to possess suture connective tissue that was less stiff (i.e., underwent more displacement before failure occurred) when loaded in tension. By decreasing stiffness, suture complexity apparently helps to dissipate mechanical loads within the cranium that are related to chewing. These results suggest that cranial suture connective tissue locally adapts to functional demands of the biomechanical suture environment. As such, cranial sutures provide a novel model for studies in connective tissue mechanotransduction. © 2004 Wiley‐Liss, Inc.
Fibroblast growth and H‐7 protein kinase inhibitor response monitored in microimpedance sensor arrays
Authors: Nguyen Duc D. , Huang Xiaoqiu , Greve David W. , Domach Michael M. 
Published: June 2004

AbstractFunctional genomic studies and drug candidate testing both require high throughput, parallel experimentation strategies to screen for variable cellular behaviors. In this article we describe the use of an impedance sensing electrode array that is capable of sensing cell “presence” as well as the extent of cell (focal) attachment to the substrate. The signals provided by mouse fibroblasts on a sensing structure containing four different sized electrodes are reported. In the absence of cells, each electrode's impedance was found to depend as expected on electrode size and frequency. The impedance increased by several‐fold when fibroblasts attached and spread out over time. More notably, the sensors also detected the cellular response to the protein kinase C inhibitor, H‐7. H‐7 inhibits actomyosin contractility; thereafter, the loss of focal adhesion complexes occurs. The sensors, in turn, detected an impedance decrease after H‐7 addition and an increase in impedance after H‐7 removal. © 2004 Wiley Periodicals, Inc.
Identification and characterization of Cu2O‐ and ZnO‐binding polypeptides by Escherichia coli cell surface display: toward an understanding of metal oxide binding
Authors: Thai Corrine K. , Dai Haixia , Sastry M. S. R. , Sarikaya Mehmet , Schwartz Daniel T. , Baneyx François 
Published: June 2004

AbstractWe have used the FliTrx cell surface display system to identify disulfide‐constrained dodecapeptides binding to the semiconducting metal oxides Cu2O and ZnO. Sequence analysis of the inserts revealed that the two populations exhibit similar, yet subtly different patterns of amino acid usage. Both sets of binders were enriched in arginine, tryptophan, and glycine with a higher degree of positional preference in the case of Cu2O binders. Tyrosine, proline, and serine were underrepresented in both populations. Peptides binding electrodeposited Cu2O or ZnO with high avidity could be subdivided into two classes based on pI and hydrophilicity. In the hydrophilic and positively charged Class I binders, the Arg–X–X–Arg tetrapeptide appears to be implicated in metal oxide binding, whereas Arg–Arg and Arg–Lys pairs allow for discrimination between Cu2O and ZnO. Molecular dynamics simulations of the disulfide‐constrained peptides suggest that the aforementioned motifs are important to properly orient two basic residues that are likely to contact the metal oxides. The implications of our results in understanding the rules governing the interaction between peptides and inorganic compounds and in their use for the design of hybrid nanoarchitectures are discussed. © 2004 Wiley Periodicals, Inc.
Treatment of peritoneal carcinomatosis from adenocarcinoid of appendiceal origin
Authors: Mahteme H , Sugarbaker P H 
Published: June 2004

Abstract

Background
Mucinous peritoneal carcinomatosis arising from appendiceal adenocarcinoid is uncommon and treatment options have been poorly defined. This study examined the effect of combined cytoreductive surgery and intraperitoneal chemotherapy on survival in these patients.

Methods
Of 810 patients with peritoneal malignancy of appendiceal origin treated by cytoreductive surgery and intraperitoneal chemotherapy, 22 patients (mean age 45 years; 17 women) had adenocarcinoid.

Results
The overall median survival was 18·5 (range 3·2–95·1) months, with 2- and 5-year survival rates of 39 and 25 per cent respectively. Survival after combined surgery and chemotherapy depended on the Peritoneal Cancer Index (P = 0·008) and the extent of cytoreduction (P = 0·007).

Conclusion
Peritoneal carcinomatosis from adenocarcinoid of appendiceal origin is as invasive as peritoneal surface malignancy from colorectal adenocarcinoma. Patients in whom complete or near-complete surgical removal is possible should be considered for cytoreduction in combination with intraperitoneal chemotherapy.
Systematic review and meta-analysis of controlled trials assessing spinal cord stimulation for inoperable critical leg ischaemia
Authors: Ubbink D T , Vermeulen H , Spincemaille G H J J , Gersbach P A , Berg P , Amann W 
Published: June 2004

Abstract

Background
Spinal cord stimulation (SCS) may have a place in the treatment of patients with inoperable chronic critical leg ischaemia.

Methods
A systematic review and meta-analysis was performed of all controlled studies comparing SCS in addition to any form of conservative treatment for inoperable chronic critical leg ischaemia. Main endpoints were limb salvage, pain relief and clinical situation. Systematic methodological appraisal and data extraction were performed by independent reviewers.

Results
Of the 18 reports found, nine trials, comprising 444 patients, matched the selection criteria. After pooling, limb salvage at 12 months appeared significantly greater in the SCS group (risk difference (RD) − 0·13 (95 per cent confidence interval (c.i.) − 0·04 to − 0·22)). Significant pain relief occurred in both treatment groups, but patients who received SCS required significantly less analgesia and reached Fontaine stage 2 more often than those who did not have SCS (RD 0·33 (95 per cent c.i. 0·19 to 0·47)). Complications of SCS were problems of implantation (8·2 per cent), changes in stimulation requiring reintervention (14·8 per cent) and infection (2·9 per cent).

Conclusion
The addition of SCS to standard conservative treatment improves limb salvage, ischaemic pain and the general clinical situation in patients with inoperable chronic critical leg ischaemia. These benefits should be weighed against the cost and the (minor) complications associated with the technique.
Interleukin 6 production during abdominal aortic aneurysm repair arises from the gastrointestinal tract and not the legs
Authors: Norwood M G A , Bown M J , Sutton A J , Nicholson M L , Sayers R D 
Published: June 2004

Abstract

Background
Abdominal aortic aneurysm (AAA) repair is associated with a systemic inflammatory response. This inflammatory response probably arises as a result of an ischaemia–reperfusion injury to the legs and gastrointestinal tract. In this study the relative contributions of these areas to the inflammatory response were assessed during elective AAA repair.

Methods
Blood was sampled from the femoral vein, portal vein and radial artery of 14 patients undergoing elective AAA repair at five time points during the procedure. Plasma was snap-frozen for subsequent batch analysis of interleukin (IL) 6.

Results
The plasma IL-6 concentration rose steadily throughout the procedure at all three locations. The increase in plasma IL-6 was significantly greater in the portal vein than in the radial artery during ischaemia (P = 0·020). The plasma IL-6 concentration was also significantly higher in the portal vein than in the femoral vein (P &lt; 0·001) and radial artery (P &lt; 0·001) during reperfusion. There were no significant differences between radial artery and femoral vein IL-6 levels at any time point.

Conclusion
Ischaemia and reperfusion during AAA repair were associated with a marked increase in IL-6 concentration in the portal vein, suggesting that IL-6 was produced by the gastrointestinal tract.
A randomized, controlled trial of aerobic exercise for treatment‐related fatigue in men receiving radical external beam radiotherapy for localized prostate carcinoma
Authors: Windsor Phyllis M. , Nicol Kathleen F. , Potter Joan 
Published: June 2004

AbstractBACKGROUNDAdvice to rest and take things easy if patients become fatigued during radiotherapy may be detrimental. Aerobic walking improves physical functioning and has been an intervention for chemotherapy‐related fatigue. A prospective, randomized, controlled trial was performed to determine whether aerobic exercise would reduce the incidence of fatigue and prevent deterioration in physical functioning during radiotherapy for localized prostate carcinoma.METHODSSixty‐six men were randomized before they received radical radiotherapy for localized prostate carcinoma, with 33 men randomized to an exercise group and 33 men randomized to a control group. Outcome measures were fatigue and distance walked in a modified shuttle test before and after radiotherapy.RESULTSThere were no significant between group differences noted with regard to fatigue scores at baseline (P = 0.55) or after 4 weeks of radiotherapy (P = 0.18). Men in the control group had significant increases in fatigue scores from baseline to the end of radiotherapy (P = 0.013), with no significant increases observed in the exercise group (P = 0.203). A nonsignificant reduction (2.4%) in shuttle test distance at the end of radiotherapy was observed in the control group; however, in the exercise group, there was a significant increase (13.2%) in distance walked (P = 0.0003).CONCLUSIONSMen who followed advice to rest and take things easy if they became fatigued demonstrated a slight deterioration in physical functioning and a significant increase in fatigue at the end of radiotherapy. Home‐based, moderate‐intensity walking produced a significant improvement in physical functioning with no significant increase in fatigue. Improved physical functioning may be necessary to combat radiation fatigue. Cancer 2004. © 2004 American Cancer Society.
Decrease in mitochondrial oxidative protein damage parameters in the streptozotocin‐diabetic rat
Authors: Kayalı Refik , Çakatay Ufuk , Telci Ayşegül , Akçay Tülay , Sivas Ahmet , Altuǧ Tuncay 
Published: June 2004

AbstractBackgroundMany authors have shown that hyperglycemia leads to an increase in oxidative protein damage in diabetes. The aim of this study was to reveal the susceptibility of mitochondria from liver, pancreas, kidney, and skeletal muscle of diabetic Sprague–Dawley rats, a model of type 1 diabetes, to oxidative protein damage.MethodsMitochondrial fractions were obtained by differential centrifugation. To show the effect of hyperglycemia in promoting oxidative protein damage, we determined mitochondrial protein carbonyl, total thiol, nitrotyrosine, advanced oxidation protein products, and lipid hydroperoxide levels. The levels of the studied markers, except nitrotyrosine, were determined by colorimetric methods. Nitrotyrosine levels were measured by ELISA. All values were compared with those of the controls by using the Mann–Whitney U‐test.ResultsNitrotyrosine and lipid hydroperoxide levels were decreased and other parameters were not changed in liver mitochondria of diabetic rats. Protein carbonyl, nitrotyrosine, advanced oxidation protein products, and lipid hydroperoxide levels were decreased and total thiol levels were not changed in pancreas mitochondria of diabetic rats. Only advanced oxidation protein products and lipid hydroperoxide levels were decreased in kidney mitochondria of diabetic rats. The levels of the same parameters were not significantly different in muscle mitochondria of diabetic rats.ConclusionsThe decrease in mitochondrial oxidative protein damage in diabetes may correspond to either an increase in antioxidant defense mechanisms or a different adaptive response of the cells to the increased extramitochondrial oxidative stress in diabetes. The mitochondrial oxidative protein damage‐lowering mechanisms in diabetes remain to be clarified. Copyright © 2004 John Wiley & Sons, Ltd.
On the self‐dual 𝔽5‐codes constructed from Hadamard matrices of order 24
Authors: Harada Masaaki 
Published: June 2004

AbstractThere are exactly 60 inequivalent Hadamard matrices of order 24. In this note, we give a classification of the self‐dual 𝔽5‐codes of length 48 constructed from the Hadamard matrices of order 24. © 2004 Wiley Periodicals, Inc.
Splitting balanced incomplete block designs with block size 3 × 2
Authors: Du Beiliang 
Published: June 2004

AbstractSplitting balanced incomplete block designs were first formulated by Ogata, Kurosawa, Stinson, and Saido recently in the investigation of authentication codes. This article investigates the existence of splitting balanced incomplete block designs, i.e., (v, 3k, λ)‐splitting BIBDs; we give the spectrum of (v, 3 × 2, λ)‐splitting BIBDs. As an application, we obtain an infinite class of 2‐splittingA‐codes. © 2004 Wiley Periodicals, Inc.