bluuebunny/crossref_metadata_2025_split huggingface dataset:
The Coordination Nanocages‐Integrated Polymer Brush Networks for Flexible Microporous Membranes with Exceptional H2/CO2 Separation Performance
Authors: Liu Yuan , Xue Binghui , Chen Jiadong , Lai Yuyan , Yin Panchao 
Published: October 2023

AbstractThe emergence of polymers with intrinsic microporosity provides solutions for flexible gas separation membranes with both high gas permeability and selectivity. However, their applications are significantly hindered by the costly synthetic efforts, limited availability of chemical systems, and narrow window of microporosity sizes. Herein, flexible mixed matrix membranes with tunable intrinsic microporosity can be facilely fabricated from the coordination assembly of polymer brushes and coordination nanocages. Polymer brushes bearing isophthalic acid side groups can coordinate with Cu2+ to assemble into polymer networks crosslinked by 2 nm nanocages. The semi‐flexible feature of the polymer brush and the high crosslinking density of the network prevent the network from collapsing during solvent removal and the obtained aerogels demonstrate hierarchical structure with dual porosity from the crosslinked polymer network and coordination nanocage, respectively. The porosity can be facilely tuned via the amount of Cu2+ by regulating the network crosslinking density and nanocage loadings, and finally, optimized gas separation that surpasses Robeson upper bound for H2/CO2 can be achieved. The coordination‐driven assembly protocol paves a new avenue for the cost‐effective synthesis of polymers with intrinsic microporosity and the fabrication of flexible gas separation membranes.
A novel method for the extraction and characterization of metabolites from Basidiomycota: Pleurotus ostreatus (Jacq.) P. Kumm., 1871 as a case study
Authors: Benvenuti Mirko , Piazza Simone Di , Salis Annalisa , Cecchi Grazia , Zotti Mirca , Scarfì Sonia , Damonte Gianluca 
Published: October 2023

AbstractIn recent years, the interest in the exploitation of fungal metabolites has grown considerably, given their application in numerous sectors involving human health. However, their identification and characterization by conventional analytical approaches is generally limited to single families of molecules per method of analysis. This constitutes a limiting factor of primary importance in the study of both the metabolic pattern of a single fungal sample and the discovery of its possible applications. In this work, a reverse‐phase high‐performance liquid chromatography coupled with mass spectrometry method for the profile determination of primary and secondary metabolites produced by the oyster‐mushroom Pleurotus ostreatus (Jacq.) P. Kumm., 1871, has been developed. By using a concomitant extraction in three different polarity‐decreasing solvents, namely methanol, ethanol, and acetonitrile, this method allowed the simultaneous analysis of all extracted metabolites belonging to the widest possible range of chemical families, giving an advantage for both qualitative and quantitative determination of known and unknown compounds. The method appears to be valuable and robust for the study of complex matrices like raw fungi extract such as those of Pleurotus ostreatus cultivated on different substrates and/or exposed to multiple stressors.
Generalized filtered lifting line theory for arbitrary chord lengths and application to wind turbine blades
Authors: Martínez‐Tossas Luis A. , Sakievich Philip , Churchfield Matthew J. , Meneveau Charles 
Published: October 2023

AbstractThe filtered lifting line theory is an analytical approach used to solve the equations of flow subjected to body forces with a Gaussian distribution, such as used in the actuator line model. In the original formulation, the changes in chord length along the blade were assumed to be small. This assumption can lead to errors in the induced velocities predicted by the theory compared to full solutions of the equations. In this work, we revisit the original derivation and provide a more general formulation that can account for significant changes in chord along the blade. The revised formulation can be applied to wings with significant changes in chord along the span, such as wind turbine blades.
Final Conclusions II: Establishing a New Monetary Order as a Foundation for a New Type of Societies
Authors: Byttebier Koen 
Published: October 2023

AbstractAfter more than two (= industrial capitalism) to four (= mercantile and industrial capitalism combined) centuries of capitalism, the balance sheet is far from rosy, at least for those who, averse to ideology, are willing to take a sober and honest look at what capitalism has brought about.
The Presence of an Aberrant Right Hepatic Artery Did Not Influence Surgical and Oncological Outcomes After Pancreaticoduodenectomy: A Comprehensive Systematic Review and Meta‐Analysis
Authors: Ricci Claudio , Alberici Laura , Minghetti Margherita , Ingaldi Carlo , Grego Davide Giovanni , D’Ambra Vincenzo , De Dona Ermenegilda , Casadei Riccardo 
Published: October 2023

AbstractBackgroundThe presence of an aberrant right hepatic artery (a‐RHA) could influence the oncological and postoperative results after pancreaticoduodenectomy (PD).MethodsA systematic review and metanalysis were conducted, including all comparative studies having patients who underwent PD without (na‐RHA) or with a‐RHA. The results were reported as risk ratios (RRs), mean differences (MDs), or hazard ratios (HRs) with 95% confidence intervals (95 CI). The random effects model was used to calculate the effect sizes. The endpoints were distinguished as critical and important. Critical endpoints were: R1 resection, overall survival (OS), morbidity, mortality, and biliary fistula (BL). Important endpoints were: postoperative pancreatic fistula (POPF), delayed gastric emptying (DGE), post pancreatectomy hemorrhage (PPH), length of stay (LOS), and operative time (OT).ResultsConsidering the R1 rate no significant differences were observed between the two groups (RR 1.06; 0.89 to 1.27). The two groups have a similar OS (HR 0.95; 0.85 to 1.06). Postoperative morbidity and mortality were similar between the two groups, with a RR of 0.97 (0.88 to 1.06) and 0.81 (0.54 to 1.20), respectively. The biliary fistula rate was similar between the two groups (RR of 1.09; 0.72 to 1.66). No differences were observed for non‐critical endpoints.ConclusionThe presence of a‐RHA does not affect negatively the short‐term and long‐term clinical outcomes of PD.
Functional similarity of ABP 959 and eculizumab in simulated serum models of aHUS and NMOSD
Authors: McBride Helen J. , Frazer-Abel Ashley , Thiemann Sandra , Lehto Sonya G. , Hutterer Katariina M. , Liu Jennifer 
Published: October 2023

AbstractABP 959 is being developed as a biosimilar to Soliris® (eculizumab) reference product (RP), which was approved under orphan designation for a group of rare diseases including paroxysmal nocturnal hemoglobinuria (PNH), atypical hemolytic uremic syndrome (aHUS), generalized myasthenia gravis (gMG), and neuromyelitis optica spectrum disorder (NMOSD). Development of biosimilars for therapeutics approved for rare disease indications must provide scientific rationale based on the totality of evidence (TOE). To support the TOE and the scientific justification for extrapolation to all approved indications for eculizumab RP, including but not limited to aHUS and NMOSD, we utilized simulated ex-vivo pharmacodynamic (PD) assessments to compare the complement component 5 (C5) inhibitory activity of ABP 959 and the RP. Hemolysis activity of CH50 and AH50, and Wieslab CP, AP, and LP endpoints represent the three complement activation pathways (classical, alternative, and lectin), all of which share the terminal pathway and require C5 for activity. These endpoints were evaluated in normal serum, simulated aHUS serum, and simulated NMOSD serum to provide a robust comparison. The results support the conclusion that ABP 959 and eculizumab RP exhibit highly similar inhibition of C5 function regardless of the type of serum used. This work presents a full comparison of the effect of C5 inhibition across five complement functional assays. Using this approach to confirm functional similarity of ABP 959 with eculizumab RP contributes to the TOE for biosimilarity and provides support for extrapolation based on inhibition of C5 function to other rare disease indications approved for eculizumab RP.
Grubenpapillen-Makulopathie: Inzidenz und klinischer Verlauf
Authors: Chan Caroline , Fries Fabian Norbert , Käsmann-Kellner Barbara , Seitz Berthold , Abdin Alaa Din 
Published: October 2023

Zusammenfassung
Ziel
Ziel dieser Fallserie ist es, den klinischen Verlauf von Patienten mit Grubenpapillen-Makulopathie zu untersuchen.

Methoden
Es wurde die Krankenakten aller Patienten ausgewertet, bei denen in den letzten 10 Jahren eine Grubenpapille diagnostiziert wurde. Eine Grubenpapillen-Makulopathie wurde diagnostiziert, wenn sich lokalisierte intraretinale oder/und subretinale Flüssigkeit vom Sehnerv zur Makula ausgebreitet hatte. Zu den Zielgrößen gehörten Veränderungen der bestkorrigierten Sehschärfe (BCVA), der zentralen Netzhautdicke (RT), der nasalen parafovealen und perifovealen RT.

Ergebnisse
Bei 18 Patienten (9 weiblich, 9 männlich, Durchschnittsalter: 33 ± 23 Jahre) wurde eine Grubenpapille diagnostiziert. Bei 6 Patienten (33,3 %) lag eine Ansammlung von Netzhautflüssigkeit vor (1 intraretinal, 1 subretinal, 4 intra- und subretinal). Eine Pars-plana-Vitrektomie mit Entfernung der peripapillären Glaskörpertraktion und ILM-Peeling wurde bei 5 Patienten indiziert und bei 4 Patienten durchgeführt. Ein Patient unterzog sich stattdessen einer Nano-Puls-Laserbehandlung. Die Patienten mit Grubenpapillen-Makulopathie waren im Durchschnitt 47 ± 16 Jahre alt. Die mittlere bestkorrigierte Sehschärfe (BCVA) (dezimal) der Patientengruppe verbesserte sich von 0,3 ± 0,2 vor der Behandlung auf 0,5 ± 0,2 3 Monate nach der Behandlung (p = 0,03). Bei allen Patienten mit Grubenpapillen-Makulopathie, die mit Pars-plana-Vitrektomie behandelt wurden, verbesserte sich der Visus. Die mittlere zentrale Netzhautdicke (RT) sank von 796 ± 214 vor der Behandlung auf 324 ± 57 3 Monate nach der Behandlung (p = 0,005). Die mittlere nasale parafoveale RT sank von 683 ± 87 vor der Behandlung auf 372 ± 41 (p = 0,0003), und die mittlere nasale perifoveale RT sank von 547 ± 89 vor der Behandlung auf 360 ± 48 (p = 0,007). Bei 4 Augen war nach einem mittleren Follow-up von 3 Monaten eine vollständig trockene Makula erreicht. Bei der langfristigen Verlaufskontrolle (2,5 ± 1,2 Jahre) trat an den vitrektomierten Augen kein Rezidiv auf.

Schlussfolgerung
In dieser Fallserie wurde festgestellt, dass bei mehr als einem Drittel der Patienten mit Grubenpapillen eine Makulopathie auftritt, die wahrscheinlich durch eine Disruption des Kuhnt-Intermediärgewebes verursacht wird. In allen Fällen war eine interventionelle Therapie indiziert, 4 davon wurden operiert und führte zu einer signifikanten Verbesserung der Funktion und der anatomischen Netzhautstrukturen.
Diagnosis and management of congenital type D esophageal atresia
Authors: Feng Cuizhu , Li Long , Zhang Yanxia , Zhao Yong , Huang Jinshi 
Published: October 2023

AbstractThis study was performed to describe the current clinical practice and outcomes of type D esophageal atresia. We retrospectively analyzed 10 patients who were diagnosed with type D esophageal atresia and underwent esophageal atresia and tracheoesophageal fistula repair in the Capital Institute of Pediatrics and Beijing Children’s Hospital from January 2017 to May 2022. Ten patients include three newborns and seven non-newborns. Seven (70%) cases were misdiagnosed as type C esophageal atresia before the first operation. Three neonatal children underwent thoracoscopic distal tracheoesophageal fistula ligation and esophageal anastomosis: the proximal tracheoesophageal fistula was simultaneously repaired with thoracoscopy in one of these children, and the proximal tracheoesophageal fistula was not detected under thoracoscopy in the other two children. Among the seven non-neonatal children, one underwent repair of the proximal tracheoesophageal fistula through the chest and the other six underwent repair through the neck. Nine patients were cured, and one died of complications of severe congenital heart disease. Type D esophageal atresia lacks specific clinical manifestations. Misdiagnosis as type C esophageal atresia is the main cause of an unplanned reoperation. Patients without severe malformations have a good prognosis.
Incidence of depression in patients with cardiovascular disease and type 2 diabetes: a nationwide cohort study
Authors: Zareini Bochra , Sørensen Katrine Kold , Blanche Paul , Falkentoft Alexander C. , Fosbøl Emil , Køber Lars , Torp-Pedersen Christian 
Published: October 2023

Abstract
Background
Estimating how type 2 diabetes (T2D) affects the rate of depression in cardiovascular disease (CVD) can help identify high-risk patients. The aim is to investigate how T2D affects the rate of depression according to specific subtypes of CVD.

Methods
Incident CVD patients, free of psychiatric disease, with and without T2D, were included from nationwide registries between 2010 and 2020. We followed patients from CVD diagnosis until the first occurrence of depression, emigration, death, 5 years, or end of study (December 31, 2021). We used time-dependent Poisson regression to estimate the incidence rates and rate ratios (IRR) of depression following subtypes of CVD with and without T2D. The model included age, sex, comorbidities, calendar year, T2D duration, educational level, and living situation as covariates.

Results
A total of 165,096 patients were included; 45,845 had a myocardial infarction (MI), 63,691 had a stroke, 19,959 had peripheral artery disease (PAD), 35,568 had heart failure (HF), and 979 were diagnosed with 2 or more CVD subtypes (= > 2 CVD’s). Baseline T2D in each CVD subtype ranged from 11 to 17%. The crude incidence rate of depression per 1000 person-years (95% confidence intervals) was: MI + T2D: 131.1 (109.6;155.6), MI: 82.1 (65.3;101.9), stroke + T2D: 287.4 (255.1;322.6), stroke: 222.4(194.1;253.6), PAD + T2D: 173.6 (148.7;201.4), PAD:137.5 (115.5;162.5), HF + T2D: 244.3 (214.6;276.9), HF: 199.2 (172.5;228.9), =  > 2 CVD’s + T2D: 427.7 (388.1;470.2), =  > 2 CVD’s: 372.1 (335.2;411.9). The adjusted IRR of depression in MI, stroke, PAD, HF, and =  > 2 CVD’s with T2D compared to those free of T2D was: 1.29 (1.23;1.35), 1.09 (1.06;1.12), 1.18 (1.13;1.24), 1.05 (1.02;1.09), and 1.04 (0.85;1.27) (p-value for interaction < 0.001).

Conclusion
The presence of T2D increased the rate of depression differently among CVD subtypes, most notable in patients with MI and PAD.
Testing and modelling of a 2.5 MW wind turbine gearbox: Influence of lubricant formulation
Authors: Fernandes Carlos M. C. G. , Ferreira Rui , Seabra Jorge H. O. , Cruz João M. , Bernardes Ricardo 
Published: October 2023

AbstractThis study aimed to evaluate the efficiency of different ISO VG 320 oil formulations used in a 2.5 MW wind turbine gearbox. Two commercially available lubricants, a mineral oil and a polyalphaolefin (PAO) lubricant, were tested under realistic operating conditions using a customized test rig.Measurements showed that the overall efficiency of the mineral lubricant was higher than that of the PAO lubricant, but the difference was only 0.1% in degree of efficiency. Detailed oil analysis revealed that the mineral lubricant generated more wear particles.A power loss model was also implemented to predict the efficiency of the gearbox, and the results of the model were found to be in agreement with the experimental results. The study concluded that the mineral oil presented higher efficiency than the PAO oil due to its lower viscosity within the narrow operating temperature range imposed on the gearbox. Nevertheless, it is important to note that the observed differences in efficiency may be attributed, in part, to measurement uncertainties and the fact that the mineral lubricant has 10% lower viscosity at the operating temperature compared to the PAO lubricant.
Quo Vadis modeling?
Authors: Michael Judith , Bork Dominik , Wimmer Manuel , Mayr Heinrich C. 
Published: October 2023

AbstractModels are the key tools humans use to manage complexity in description, development, and analysis. This applies to all scientific and engineering disciplines and in particular to the development of software and data-intensive systems. However, different methods and terminologies have become established in the individual disciplines, even in the sub-fields of Informatics, which raises the need for a comprehensive and cross-sectional analysis of the past, present, and future of modeling research. This paper aims to shed some light on how different modeling disciplines emerged and what characterizes them with a discussion of the potential toward a common modeling future. It focuses on the areas of software, data, and process modeling and reports on an analysis of the research approaches, goals, and visions pursued in each, as well as the methods used. This analysis is based on the results of a survey conducted in the communities concerned, on a bibliometric study, and on interviews with a prominent representative of each of these communities. The paper discusses the different viewpoints of the communities, their commonalities and differences, and identifies possible starting points for further collaboration. It further discusses current challenges for the communities in general and modeling as a research topic in particular and highlights visions for the future.
Glycerol-Based Green RP-HPLC Method for Simultaneous Determination of Methionine and Paracetamol in Pharmaceutical Tablets
Authors: Habib Ahmed , Mabrouk Mokhtar M. , Fekry Marwa , Mansour Fotouh R. 
Published: October 2023

AbstractMethionine and paracetamol are combined in dosage forms due to the ability of methionine to compensate the deficiency in glutathione in hepatic patients. In this work, an innovative simple time-saving green RP-HPLC method using glycerol as a solely green mobile phase with water for the first time was developed for the simultaneous determination of methionine and paracetamol in their standard and in Hepamol® tablets. The chromatographic conditions were optimized using factorial design with the aid of Minitab 17® Software. The method was performed on a C18 column at 38 °C, and a mobile phase consisting of glycerol and phosphate buffer (pH 2.4) (40:60, v/v), using diode array detector at 210 nm. The mixture was separated in 5 min. The developed method was validated in accordance with ICH requirement over linearity ranges of 10–90 μg/mL for both drugs, and LODs were 3.33 μg/mL for both methionine and paracetamol. Glycerol has high safety, low UV cut-off point, low flammability, and its viscosity can be manipulated when diluted with water. The procedure was compared to the reported reversed phase liquid chromatography method in the terms of their greenness with the green analytical procedure index and the analytical eco-scale. This work breaks new ground for scientists to use glycerol in greener RP-HPLC applications.
Consumption Modelling Using Categorisation-Enhanced Mental Accounting
Authors: Chudziak Szymon 
Published: October 2023

AbstractCredibly representing category-of-goods mental accounting in an intertemporal optimisation framework is notoriously difficult, as this modelling approach imposes interrelations between the demand for different categories through first-order conditions. This breaks the principle of nonfungibility, contrary to the rationale of mental-accounting theory. Proofs that using intertemporal optimisation is futile in modelling this kind of behaviour are provided, and an alternative is developed: a procedural-behavioural merger of mental accounting and categorisation theories. The merger is necessary to enhance mental-accounting theory, which by itself does not inform about how mental budgets are formed, what they include and how money is spent from various accounts. A classification of six basic consumer types was devised, basing on the differences between their mental-accounting systems and variations of changes of expenditure in response to fluctuations of net disposable income and other possible stimuli. Representing the consumer problem as a behavioural procedure including spending on nondurable and frequently-bought durable goods as well as decisions whether or not to purchase very expensive durable goods, such as houses and flats, allows to model real-world features such as infrequent purchases and rare debt-taking. The devised working-life cycle models of consumer behaviour are consistent with microeconomic evidence on consumption, including those features that are not accounted for by various versions of the permanent income or buffer-stock models.
Sample Size Requirements to Test Subgroup-Specific Treatment Effects in Cluster-Randomized Trials
Authors: Wang Xueqi , Goldfeld Keith S. , Taljaard Monica , Li Fan 
Published: October 2023

AbstractCluster-randomized trials (CRTs) often allocate intact clusters of participants to treatment or control conditions and are increasingly used to evaluate healthcare delivery interventions. While previous studies have developed sample size methods for testing confirmatory hypotheses of treatment effect heterogeneity in CRTs (i.e., targeting the difference between subgroup-specific treatment effects), sample size methods for testing the subgroup-specific treatment effects themselves have not received adequate attention—despite a rising interest in health equity considerations in CRTs. In this article, we develop formal methods for sample size and power analyses for testing subgroup-specific treatment effects in parallel-arm CRTs with a continuous outcome and a binary subgroup variable. We point out that the variances of the subgroup-specific treatment effect estimators and their covariance are given by weighted averages of the variance of the overall average treatment effect estimator and the variance of the heterogeneous treatment effect estimator. This analytical insight facilitates an explicit characterization of the requirements for both the omnibus test and the intersection–union test to achieve the desired level of power. Generalizations to allow for subgroup-specific variance structures are also discussed. We report on a simulation study to validate the proposed sample size methods and demonstrate that the empirical power corresponds well with the predicted power for both tests. The design and setting of the Umea Dementia and Exercise (UMDEX) CRT in older adults are used to illustrate our sample size methods.