bluuebunny/crossref_metadata_2025_split huggingface dataset:
Construction of high‐throughput magnetic circular dichroism measurement system and its application to research on magnetic and optical properties of phthalocyanine complexes
Authors: Suzuki Satoko , Kaneta Akio , Santria Anas , Yoshida Kengo , Oyama Taiji , Imai Yoshitane , Akao Ken‐ichi , Ishikawa Naoto 
Published: February 2024

AbstractMagnetic circular dichroism (MCD) spectroscopy is a powerful method for evaluating the electronic structure and magnetic and optical properties of molecules. In particular, MCD measurements have been performed on phthalocyanines and porphyrins with various central metal ions, axial ligands, and substituents to elucidate their properties. It is essential to develop a robust high‐throughput technique to perform these measurements comprehensively and efficiently. However, MCD spectroscopy requires very high optical quality for each component of the instrument, and even slight cell distortions can impair the baseline flatness. Consequently, when versatility and data quality are important, an optical system designed for a microplate reader is not suitable for the MCD spectrometer. Therefore, in this study, we develop a new magnetic flow‐through cell and combine it with an existing CD spectrometer and autosampler to construct a high‐throughput system. The effectiveness and performance of this new system are then evaluated. In addition, based on the MCD and absorption spectra of various phthalocyanine complexes, the effects of substituents and solvents on their magnetic and optical properties and the causes of these effects are discussed. The results demonstrate that this system is effective for the evaluation of the physicochemical properties of various phthalocyanine complexes.
Hemodialysis Wastewater Treatment via Electrocoagulation and Electro‐Oxidation: Modular Pilot‐Level Modeling and Simulation
Authors: González‐Nava Víctor Julián , Cárdenas Mijangos Jesús , Frausto‐Castillo Roberto Fernando , Bustos Bustos Erika 
Published: February 2024

AbstractHemodialysis treatment in specialized clinics within the same hospital significantly impacts environmental water health due to contaminated wastewater. The issues observed included changes in electrical conductivity, the presence of dangerous bacterial loads, toxicity from heavy metals, total cyanide content, and helminth parasite eggs. The level of damage is dependent on the patient's health under treatment. This research will use a modular system that employs electrocoagulation and electro‐oxidation processes at the laboratory and pilot levels to treat hemodialysis wastewater using synthetically prepared and real samples extracted from local clinics. The results showed that these hybrid systems improved various physicochemical parameters. Specifically, decreases in electrical conductivity of 49 %, total suspended solids of 27–100 %, chemical oxygen demand of 49 %, biochemical oxygen demand of 49 %, and cation and anion loading were observed at 96–100 % and pH 8.13 UpH in accordance with the established standards. With these results and the experimental conditions used, the proposed treatment system was modeled using the GPS‐X program, and it was concluded that the modular system used and the electrocoagulation/electro‐oxidation/activated carbon configuration is suitable for treating wastewater from hemodialysis and that scaling up this process to facilities that have dialysate machines more advanced than those considered in this work is possible.
Land use predicts proportion of West Nile virus vector‐competent mosquitoes
Authors: Bauer Amely M. , Guralnick Robert P. , Whitehead Shelley A. , Barve Narayani , Allen Julie M. , Campbell Lindsay P. 
Published: February 2024

AbstractLand use and land cover (LULC) change has been identified as an important driver of emerging mosquito‐borne zoonotic diseases. However, studies are often limited to individual vector species, despite the potential for interspecific variation in vector competency within mosquito assemblages. This variation can affect transmission hazard, particularly in complex multi‐vector disease systems. Here, we used a joint species distribution modeling approach that included mosquito species vector competency for West Nile virus (WNV) as a trait to understand community‐level responses to land cover and predict joint species distributions in Manatee County, Florida. We assembled species presence/absence data across 61 sites and 44 species sampled from 2016 to 2020 and percent land cover within 2500 m of trap locations for five common land cover types. These data were used to investigate patterns in species richness and community‐weighted proportions of WNV‐competent vector species. The results revealed that land cover effects on individual species aligned with known habitat associations: the highest proportions of WNV‐competent species were predicted in less diverse urbanized areas, and species richness increased as urbanized areas decreased. Our findings highlight the value of community‐level analyses to predict joint vector distributions that can inform where greatest transmission hazard may occur. This information can be used by public health agencies, mosquito control, and land managers to plan more effective and optimized prevention and control efforts.
Ring‐Opening Functionalization/Cyclization Reactions of Cycloalkanols under Transition‐Metal‐Free Conditions
Authors: Han Wen‐Jun , Zhan Jun‐Long , Yang Fang‐Long , Liu Lantao 
Published: February 2024

AbstractCycloalkanols ring‐opening transformation is one of the most valuable and wide area of research. Among the numerous methods that have been developed, transition‐metal‐free approaches have attracted great interest from both chemists and pharmacologists. This is largely due to the advantages of being environmentally benign, cost‐effective and operationally simple. Here we provide a comprehensive outline on recent advances in the synthesis of distally substituted ketones and cyclic compounds via ring‐opening transformation of cycloalkanols under transition‐metal‐free conditions.
Improving Sediment Toxicity Testing for Very Hydrophobic Chemicals: Part 2—Exposure Duration, Upper Limit Test Concentrations, and Distinguishing Actual Toxicity from Physical Effects
Authors: Jonker Michiel T. O. , Diepens Noël J. 
Published: February 2024

Abstract
Sediment toxicity testing with very hydrophobic organic chemicals (VHOCs) is challenging because of the chemicals’ low aqueous solubilities and slow kinetics. The present study presents the results of experiments investigating whether the standard exposure duration of 28 days with benthic invertebrates is sufficient for VHOCs; above which concentrations in sediment VHOCs are present as “free phase,” that is, crystals or non-aqueous-phase liquids (NAPLs); and whether it is possible to discriminate between actual VHOC toxicity and physical effects caused by NAPLs through fouling of the test organisms. The results suggest that the standard sediment toxicity test duration is sufficient for obtaining steady-state VHOC concentrations in Hyalella azteca and Lumbriculus variegatus, provided that spiking and equilibration are performed properly (i.e., no free phase present). Under these conditions, transient (days 3–20) peak-shaped toxicokinetics were observed, with steady-state concentrations reached at approximately 28 days. The concentration above which NAPLs are present, the so-called critical separate phase concentration (CSPC), was determined for several VHOCs by modeling and two experimental methods. Modeling resulted in unrealistic and variable data and therefore should be applied with caution. Experimentally determining CSPCs was successful and yielded values of approximately 1000 (400–2000) mg/kg dry weight, depending on the chemical. Finally, it was demonstrated that distinguishing actual toxicity from physical effects is possible by applying a well-considered test setup, combining toxicity tests with multiple invertebrates (including Lumbriculus, which serves as a negative control for fouling); a broad test concentration range, preferably up to at least 30 000 mg/kg; and passive sampling to localize the CSPC. Applying this setup, false-positive effects due to fouling, as well as false-negative results due to testing at too low concentrations (trying to stay below the CSPC), can be avoided. Environ Toxicol Chem 2024;43:1728–1739. © 2023 The Authors. Environmental Toxicology and Chemistry published by Wiley Periodicals LLC on behalf of SETAC.
‘If I'm not sick, I'm not going to see the doctor’: Access to preventive sexual and reproductive health care for Karen women from refugee backgrounds living in Melbourne, Australia—A qualitative study
Authors: Davidson Natasha , Hammarberg Karin , Fisher Jane 
Published: February 2024

AbstractIssue AddressedWomen from refugee backgrounds have poorer health outcomes than host country populations. People from Myanmar, most of whom are from the Karen ethnic minority constitute one of the largest groups of humanitarian visa entrants to Australia since 2015. Barriers to and enablers of preventive sexual and reproductive health (SRH) for this group of women are poorly understood. The objective is to establish the preventive SRH care needs and experiences of Karen women from refugee backgrounds living in Australia.MethodsA qualitative study using semi‐structured interviews was conducted with a purposive sample of Karen women. A bi‐cultural worker assisted in recruitment and interpreting during data collection. All interviews were conducted in Karen language with a bi‐cultural worker interpreting into English during the interview. Audio recordings of English dialogue were transcribed verbatim. Thematic analysis was used to analyse and report data.ResultsThirteen women were interviewed. Five major themes were identified: (1) prevention awareness including lack of access to education and knowledge of services pre‐arrival; appreciation of the new health system; limited vaccination knowledge, (2) perceived need for prevention including consequences of not screening; health care provider (HCP) attendance, (3) health information seeking including providing a comprehensive approach to information delivery; trusted sources of information, (4) barriers including missed opportunities; communication, language, illiteracy; lack of continuity of care and, (5) enablers including HCP’ characteristics; peer support and individual responsibility.ConclusionFindings from this study indicate that to improve access to preventive SRH services a multi‐component strategy is needed. Provision of preventive SRH information using a multi‐pronged approach; peer and community support interventions; and HCPs offering services and information opportunistically would benefit Karen women unfamiliar with preventive SRH care.So What?Primary prevention services and education codesigned with community members may be effective in improving Karen women's access to SRH care.
Analyzing the expression pattern of the noncoding RNAs (HOTAIR, PVT‐1, XIST, H19, and miRNA‐34a) in PBMC samples of patients with COVID‐19, according to the disease severity in Iran during 2022–2023: A cross‐sectional study
Authors: Khanaliha Khadijeh , Sadri Nahand Javid , Khatami AliReza , Mirzaei Hamed , Chavoshpour Sara , Taghizadieh Mohammad , Karimzadeh Mohammad , Donyavi Tahereh , Bokharaei‐Salim Farah 
Published: February 2024

AbstractBackground and aimsMicroRNAs (miRNAs) and long noncoding RNAs (lncRNAs) are well‐known types of noncoding RNAs (ncRNAs), which have been known as the key regulators of gene expression. They can play critical roles in viral infection by regulating the host immune response and interacting with genes in the viral genome. In this regard, ncRNAs can be employed as biomarkers for viral diseases. The current study aimed to evaluate peripheral blood mononuclear cell (PBMC) ncRNAs (lncRNAs‐homeobox C antisense intergenic RNA [HOTAIR], ‐H19, X‐inactive‐specific transcript [XIST], plasmacytoma variant translocation 1 [PVT‐1], and miR‐34a) as diagnostic biomarkers to differentiate severe COVID‐19 cases from mild ones.MethodsCandidate ncRNAs were selected according to previous studies and assessed by real‐time polymerase chain reaction in the PBMC samples of patients with severe coronavirus disease 2019 (COVID‐19) (n = 40), healthy subjects (n = 40), and mild COVID‐19 cases (n = 40). Furthermore, the diagnostic value of the selected ncRNAs was assessed by analyzing the receiver‐operating characteristic (ROC).ResultsThe results demonstrated that the expression pattern of the selected ncRNAs was significantly different between the studied groups. The levels of HOTAIR, XIST, and miR‐34a were remarkably overexpressed in the severe COVID‐19 group in comparison with the mild COVID‐19 group, and in return, the PVT‐1 levels were lower than in the mild COVID‐19 group. Interestingly, the XIST expression level in men with severe COVID‐19 was higher compared to women with mild COVID‐19. ROC results suggested that HOTAIR and PVT‐1 could serve as useful biomarkers for screening mild COVID‐19 from severe COVID‐19.ConclusionsOverall, different expression patterns of the selected ncRNAs and ROC curve results revealed that these factors can contribute to COVID‐19 pathogenicity and can be considered diagnostic markers of COVID‐19 severe outcomes.
Economic evaluation of vaccination against COVID‐19: A systematic review
Authors: Zeinab Dolatshahi , Shahin Nargesi , Fateme Mezginejad , Saeed Bagheri Faradonbeh 
Published: February 2024

AbstractBackground and AimsCoronavirus has burdened considerable expenditures on the different health systems. Vaccination programs, the critical solution against pandemic diseases, are known as safe and effective interventions to prevent and control epidemics. We aimed to perform a systematic review to provide economic evidence of the value of different types of vaccines available to combat the Covid‐19 to all health policymakers worldwide.MethodsElectronic searches conducted on Medline/PubMed, Cochrane Library, Web of Science, Scopus, Embase, and other economic evaluation databases. Related and published articles searched up to March 2022 by using keywords such as “Vaccination,” “Covid‐19,” “Cost‐benefit,” “Cost‐utility,” “Cost‐effectiveness,” “Economic Assessment,” and “Economic evaluation.” Followed by choosing the most suitable articles according to inclusion and exclusion criteria, data captured and the results extracted. The quality assessment of the articles performed by the checklist of CHEERS 2022. Finally, 13 articles included in the review.ResultsAll messenger RNA vaccines were dominant with approximately 70% coverage against no vaccination in the primary vaccination program except in one study that looked at booster effects. From a payer's perspective, a dollar invested in a vaccine would be less profitable than from a societal perspective. Therefore, primary mass vaccination can be considered a cost‐effective intervention in primary vaccination to save more lives and produce more positive externalities. However, the cost‐benefit ratio for all vaccines increases when statistical lifetime value and global economic and educational disadvantages are considered.ConclusionThe COVID‐19 primary vaccination programs in regional outbreaks, from a long‐term perspective, will demonstrate substantial cost‐effectiveness. It is suggested that due to the positive externalities of vaccination, primary mass vaccination, with the help of COVAX‐19TM, could be considered a reliable way to combat viral epidemics compared to the loss of individual lives and economic and educational disturbances around the world.
Evaluation of cross‐cultural adaptation and validation of the Persian version of the health literacy for school‐aged children scale: Methodological study
Authors: Negarandeh Reza , Sarkhani Naeimeh , Heydari Maryam 
Published: February 2024

AbstractBackground and AimsHealth literacy (HL) is an essential determinant of health in children. Inadequate HL causes problems for individuals and society, such as more hospitalizations, medication errors, poor health, and higher mortality and health care costs. A valid and reliable scale is needed to measure this population's HL. This study evaluated the cross‐cultural adaptation and validation of the Persian version of the HL for School‐Aged Children (HLSAC) Scale.MethodsIn this methodological research, the HL scale of school‐aged children was translated from English to Persian using the Backward–Forward translation protocol. The content validity, face validity, construct validity (Exploratory Factor Analysis [EFA] and Confirmatory factor analysis [CFA]), plus reliability, were evaluated by Internal consistency and stability methods. Two hundred forty samples from south of Tehran were selected by multi‐stage sampling method to assess the construct validity. Data analysis was performed using SPSS v24 and Jamovi v2.2.ResultsA qualitative evaluation of face and content validity showed that experts and the target group approved all items on the scale. The results of EFA indicated the existence of one factor, explaining 47.17% of the total variance of the scale. The CFA results showed that the one‐factor model of the Persian version of the HL scale for children is almost acceptable. (χ2/df = 2.94, Root Mean Square Error of Approximation = 0.09, Normed‐Fit Index = 0.89, Tucker‐Lewis Index = 0.89, Comparative Fit Index = 0.92). Cronbach's alpha coefficient for the whole scale was 0.80, and the Intraclass Correlation Coefficient value for the whole scale was calculated as 0.78 using the single‐rating, absolute‐agreement, 2‐way mixed‐effects method.ConclusionThe study validates the HLSAC Scale, affirming its suitability for assessing HL in Persian‐speaking child populations.
Patient‐reported outcomes in advanced NSCLC before and during the COVID‐19 pandemic: Real‐world data from the German prospective CRISP Registry (AIO‐TRK‐0315)
Authors: Sebastian Martin , Eberhardt Wilfried E. E. , von der Heyde Eyck , Dörfel Steffen , Wiegand Jörg , Schiefer Clemens , Losem Christoph , Jänicke Martina , Fleitz Annette , Zacharias Stefan , Kaiser‐Osterhues Anja , Hipper Annette , Dietel Corinna , Bleckmann Annalen , Benkelmann Robin , Boesche Michael , Grah Christian , Müller Annette , Griesinger Frank , Thomas Michael ,   for the CRISP Registry Group
Published: February 2024

AbstractPatients with lung cancer under treatment have been associated with a high risk of COVID‐19 infection and potentially worse outcome, but real‐world data on patient‐reported outcomes (PROs) are rare. We assess patients' characteristics and PROs before and during the COVID‐19 pandemic in an advanced non‐small cell lung cancer (NSCLC) cohort in Germany. Patients with locally advanced or metastatic NSCLC from the prospective, multicentre, observational CRISP Registry (NCT02622581) were categorised as pre‐pandemic (March 2019 to Feb 2020, n = 1621) and pandemic (March 2020 to Feb 2021, n = 1317). From baseline to month 15, patients' health‐related quality of life (HRQoL) was assessed by FACT‐L, anxiety and depression by PHQ‐4. Association of pandemic status with time to deterioration (TTD) in QoL scales adjusted for potential covariates was estimated using Cox modelling. PROs were documented for 1166 patients (72%) in the pre‐pandemic, 979 (74%) in the pandemic group. Almost 60% of patients were male, median age was 66 years, comorbidities occurred in 85%. Regarding HRQoL, mean‐change‐from‐baseline plots hardly differed between both samples. Approximately 15%–21% of patients reported anxiety, about 19%–27% signs of depression. For the pandemic group, TTD was slightly, but statistically significantly, worse for the physical well‐being‐FACT‐G subscale (HR 1.15 [95%CI 1.02–1.30]) and the anxiety‐GAD‐2 subscale (HR 1.14 [95%CI 1.01–1.29]). These prospectively collected real‐world data provide valuable insights into PROs before and during the COVID‐19 pandemic in advanced NSCLC. For the patients, the pandemic seemed to be less of a burden than the disease itself, as there was a considerable proportion of patients with anxiety and depression in both groups.
Perceived loss of support to community caregivers during the COVID‐19 pandemic in the United States
Authors: Kennedy David P. , Friedman Esther M. , Kirkegaard Allison , Edgington Sarah , Shih Regina 
Published: February 2024

AbstractCoronavirus disease (COVID‐19) had a negative impact on the health and well‐being of community caregivers. Few studies examine the pandemic's negative impact on the availability of social networks of caregivers. This article uses data collected during COVID‐19 before vaccination to examine caregivers' reports of perceived lost and reduced network support. We assessed the personal networks of a nationally representative sample of 2214 community caregivers in the United States. We analyzed associations between caregiving factors and caregivers' perceptions of lost and reduced network support. Changes in care recipient living circumstances during COVID‐19, longer‐term caregiving, care recipient hearing/vision/mobility problems, caregiver travel/socializing restrictions, caregiver race/ethnicity, caregiver income, caregiver age, network connectivity, family relationships, and network members' age were associated with perceived lost/reduced support during the pandemic. Findings provide insights for the development of social network interventions to support caregivers and help them cultivate support networks resilient to public health crises.
Photothermal dependence on catalytic activity and selectivity of HMF and benzyl alcohol oxidation over Pd/1D‐TiO2 nanotubes
Authors: Dai Likai , Fang Zheng , Peng Anxian , Chen Yunhong , Liu Yitong , Chen Huimei , Yan Rongjun , Zhou Rencheng , Du Mingming 
Published: February 2024

AbstractBACKGROUNDPhotothermal catalytic oxidation technology for synthesis of high value‐added chemicals has become a hot topic of research at home and abroad. As a special structure, titania (TiO2) nanotubes (Ti‐NTs) possess larger specific surface area and adsorption capacity, which have shown great application prospects in photothermal catalytic oxidation.RESULTSIn this work, high‐performance palladium (Pd‐Ti‐NTs catalyst were prepared and applied to the photothermal catalytic oxidation of 5‐hydroxymethyl (HMF) and benzyl alcohol. The photothermal dependence on catalytic activity and selectivity of HMF and benzyl alcohol oxidation was studied in detail. The results revealed that compared with thermal catalytic oxidation, the catalysts showed significantly higher conversions of both benzyl alcohol and HMF under light. in particular, HMF conversion increase from 55.6% to 99.7%. Aldehyde oxidation is inhibited by alcohol and can be dramatically promoted by light radiation. This is probably because alcohol can inhibit the adsorption of aldehyde, and this inhibiting effect is weakened through light radiation, thus promoting the oxidation of aldehydes. Therefore, the selectivity of the final products 2,5‐furandicarboxylic acid (FDCA) and benzoic acid were dramatically increased in both systems under light radiation, and the selectivity for FDCA was obviously increased from 5.8% to 61.3%, and the yield reached 61.0%, which is higher than that of most of the reported Pd‐TiO2‐based catalysts for FDCA.CONCLUSIONSIn this paper, we verify that Pd‐Ti‐NTs could preferentially promote the conversion of aldehydes to acids in the presence of light, and obtained catalysts with high catalytic performance and high stability for benzyl alcohol and HMF oxidation. © 2024 Society of Chemical Industry (SCI).