bluuebunny/crossref_metadata_2025_split huggingface dataset:
Shift work is associated with extensively disordered sleep, especially when working nights
Authors: Boersma G. J. , Mijnster T. , Vantyghem P. , Kerkhof G. A. , Lancel Marike 
Published: December 2023

BackgroundShift work is generally associated with working and sleeping out of phase with the endogenous, circadian sleep–wake cycle. This exerts detrimental effects on sleep health. The present study aimed at evaluating the presence of short and long sleep as well as sleep disorders within a broad range of shift work schedules and elucidating the role of sociodemographic factors therein.MethodsA large dataset containing information on sleep was collected through advertisement in a Belgium newspaper (De Standaard). Adult, working individuals were selected (n = 37,662) and categorized based on their work schedule (regular day, early morning, evening, night, and rotating shift). In this cross-sectional study, prevalence rates of short sleep (≤6 h), long sleep (≥9 h) and sleep disorders (screened with Holland Sleep Disorders Questionnaire), and associations between these sleep variables and sociodemographics (age, sex, education, living companion(s)) were analyzed using binominal logistic regression analyses.ResultsIn the total sample all sociodemographic factors affected prevalences of short, long and disordered sleep, consistent with previous studies. Compared to day workers, shift workers more frequently reported short sleep, most prominently night workers (26 vs. 50%) (p &lt; 0.001). Furthermore, all sleep disorders as well as sleep disorder comorbidity were more common in shift workers, again most pronounced in night workers (all p &lt; 0.05). In night shift workers the level of education had the strongest associations with disturbed sleep with a two-fold higher prevalence of short and disordered sleep in low relative to academic educated groups (all p &lt; 0.02).ConclusionShift work is related not only to curtailed sleep and shift work disorder, but also to a plethora of sleep disorders, including insomnia, sleep-related breathing disorders and sleep-related movement disorders. Our findings imply that education on coping strategies may be especially important for young and/or lower educated shift workers.
A time-course prediction model of global COVID-19 mortality
Authors: Ciaccio Mark , Schneiderman Chris , Pandey Abhishek , Fowler Robert , Chiou Kevin , Koeller Gage , Hallett David , Krueger Whitney , Raskin Leon 
Published: December 2023

IntroductionThe COVID-19 pandemic has caused over 6 million deaths worldwide and is a significant cause of mortality. Mortality dynamics vary significantly by country due to pathogen, host, social and environmental factors, in addition to vaccination and treatments. However, there is limited data on the relative contribution of different explanatory variables, which may explain changes in mortality over time. We, therefore, created a predictive model using orthogonal machine learning techniques to attempt to quantify the contribution of static and dynamic variables over time.MethodsA model was created using Partial Least Squares Regression trained on data from 2020 to rank order the significance and effect size of static variables on mortality per country. This model enables the prediction of mortality levels for countries based on demographics alone. Partial Least Squares Regression was then used to quantify how dynamic variables, including weather and non-pharmaceutical interventions, contributed to the overall mortality in 2020. Finally, mortality levels for the first 60 days of 2021 were predicted using rolling-window Elastic Net regression.ResultsThis model allowed prediction of deaths per day and quantification of the degree of influence of included variables, accounting for timing of occurrence or implementation. We found that the most parsimonious model could be reduced to six variables; three policy-related variables – COVID-19 testing policy, canceled public events policy, workplace closing policy; in addition to three environmental variables – maximum temperature per day, minimum temperature per day, and the dewpoint temperature per day.ConclusionCountry and population-level static and dynamic variables can be used to predict COVID-19 mortality, providing an example of how broad temporal data can inform a preparation and mitigation strategy for both COVID-19 and future pandemics and assist decision-makers by identifying population-level contributors, including interventions, that have the greatest influence in mitigating mortality, and optimizing the health and safety of populations.
The relationship between hypertriglyceridemic wait-to-height ratio and hypertension–diabetes comorbidity among older adult
Authors: Zhang Ping , Xiong Yangyang , Chen Menghan , Zhang Huaide , Sun Nan , Wu Fan , Yang Jiayu , Ren Yongcheng 
Published: December 2023

ObjectiveLimited information is available on the effect of hypertriglyceridemic waist-to-height ratio (HTHWH) and hypertension–diabetes comorbidity (HAD) in older adult people. We aimed to explore the relationship between HTHWH and HAD for the co-management of hypertension and diabetes mellitus in the older adult.MethodsA cross-sectional study, randomized cluster sampling from 10 community health service centers, and multivariate logistic regression were used in this study. A total of 3,501 participants aged 65 years or older recruited between January 2019 and December 2019 completed the study.ResultsAmong 3,501 participants, the median age was 69.96 years, and 42.50% were men. A total of 1,207 subjects were in the HTHWH group, and the prevalence rate of HAD was 17.23% in this group. Multivariate logistic regression analysis showed that, as compared with the normal group, the risk of HAD in the HTHWH group increased by 2.05 times (OR = 3.05, 95% CI: 2.06–4.51). The risks of hypertension or diabetes mellitus (HOD), hypertension, and diabetes mellitus were also increased in the HTHWH group, with their ORs (95%CIs) being 1.82 (1.44–2.29), 1.73 (1.38–2.17), and 2.28 (1.66–3.13), respectively.ConclusionHTHWH significantly increases the risk of HAD and can be used as a reliable tool to screen the high-risk population for HAD.
Comparing trimodal therapy with radical cystectomy in muscle-invasive bladder cancer: an updated meta-analysis
Authors: Al-Qudimat Ahmad R. , Singh Kalpana , Ojha Laxmi K. , Moustafa Diala Alhaj , Elaarag Mai , Al-Zoubi Raed M. , Aboumarzouk Omar M. 
Published: December 2023

BackgroundWe conducted this meta-analysis to compare the two muscle-invasive bladder cancer (MIBC) treatment modalities in terms of cancer-specific survival (CSS) and other outcome indicators.MethodA systematic review and meta-analysis were performed in accordance with the Preferred Reporting Items for Systematic Reviews (PRISMA) guidelines. The search was conducted using various academic databases including Scopus, PubMed, Cochrane database, EMBASE, Chinese biomedical literature database, Wan fang databases, and China National Knowledge Internet databases between 1966 and December 2023. This review protocol was registered in the International Prospective Register of Systematic Reviews (PROSPERO) No. (CRD42023398977).ResultThis study included a total of 54,816 patients diagnosed with bladder cancer from 14 studies, of which 6,228 patients were assigned to the trimodal therapy (TMT) group and 48,588 patients were assigned to the radical cystectomy (RC) group. Based on the results, the RC group exhibited a higher rate of survival than the TMT group [pooled hazard ratio (HR) = 1.23, 95% CI: 1.18–1.28, Z = 1.46, P &lt; 0.001]. In terms of CSS, patients in the RC group had a longer CSS compared with those in the TMT group (pooled HR = 1.47, 95% CI: 1.29–1.67, Z = 5.893, P &lt; 0.001). Compared with RC, TMT is significantly associated with an increased risk of both types of mortality (pooled HR: 1.30, P &lt; 0.001).ConclusionOverall, the findings of this meta-analysis suggest that RC treatment may be associated with improved overall survival. Moreover, it was observed that cancer-specific survival was significantly prolonged among patients in the RC group as opposed to those who received TMT. In addition, it was shown that patients who received TMT exhibited a higher risk of all-cause mortality when compared with those who underwent RC.
A Hydrolase Produced by Rhodococcus erythropolis HQ Is Responsible for the Detoxification of Zearalenone
Authors: Hu Junqiang , Du Shilong , Qiu Han , Wu Yuzhuo , Hong Qing , Wang Gang , Mohamed Sherif Ramzy , Lee Yin-Won , Xu Jianhong 
Published: December 2023

Zearalenone (ZEN), an estrogenic mycotoxin, is one of the prevalent contaminants found in food and feed, posing risks to human and animal health. In this study, we isolated a ZEN-degrading strain from soil and identified it as Rhodococcus erythropolis HQ. Analysis of degradation products clarified the mechanism by which R. erythropolis HQ degrades ZEN. The gene zenR responsible for degrading ZEN was identified from strain HQ, in which zenR is the key gene for R. erythropolis HQ to degrade ZEN, and its expression product is a hydrolase named ZenR. ZenR shared 58% sequence identity with the hydrolase ZenH from Aeromicrobium sp. HA, but their enzymatic properties were significantly different. ZenR exhibited maximal enzymatic activity at pH 8.0–9.0 and 55 °C, with a Michaelis constant of 21.14 μM, and its enzymatic activity is 2.8 times that of ZenH. The catalytic triad was identified as S132-D157-H307 via molecular docking and site-directed mutagenesis. Furthermore, the fermentation broth of recombinant Bacillus containing ZenR can be effectively applied to liquefied corn samples, with the residual amount of ZEN decreased to 0.21 μg/g, resulting in a remarkable ZEN removal rate of 93%. Thus, ZenR may serve as a new template for the modification of ZEN hydrolases and a new resource for the industrial application of biological detoxification. Consequently, ZenR could potentially be regarded as a novel blueprint for modifying ZEN hydrolases and as a fresh resource for the industrial implementation of biological detoxification.
Sa'dî'nin Tercüme-i Hilye-i Şerîf Adlı Mensur Eseri
Authors: ERDOĞAN TAŞ Mehtap 
Published: December 2023

Hilye, temelde Hz. Muhammed’e duyulan derin sevgi ve bağlılık sebebiyle ortaya çıkan edebî türlerden biridir. Arap ve Fars edebiyatında örneğine rastlanmayan bu tür, Hâkânî (öl.1606)’nin Hilye-i Sa‘âdet adlı eserinin tesiriyle rağbet görüp manzum olarak gelişmiş göstermiş ve Türk edebiyatında zamanla Hz. Muhammed’in yanı sıra farklı İslam büyüklerini de konu edinen kırktan fazla manzum hilye kaleme alınmıştır. Diğer yandan tartışmalar olmakla birlikte l7. yüzyılda meşhur hattat Hafız Osman Efendi (öl. 1698) tarafından levha hilyelerin ilk örneği verilmiş ve hilye türü farklı bir mecrada gelişmeye devam etmiştir. Çalışmamızın asıl konusunu oluşturan mensur hilyelere gelince Şeyhülislam Hoca Sa‘deddîn Efendi (doğ.1537-öl.1599) tarafından kaleme alınan Hilye-i Celiyye ve Şemâ’il-i ‘Aliyye adlı eser, bilinen ilk mensur hilye olarak dikkat çeker. Bugün için müellifi tespit edilemeyen mensur hilyelerin yanı sıra müellifi bilinen yirmi civarında mensur hilye de bulunmaktadır. Bu mensur hilyeler, Tirmizî’nin eş-Şemâ’ilü’n-nebeviyye’si ile bu esere yazılan şerhlerin, Kadı İyâz’ın Şifâ adlı eserinin ve Hz. Muhammed’i tanıyan, yakından gören bazı sahabilerin sözlerinin tercüme edilmesi suretiyle vücuda getirilmiştir. Bu eserlerden biri de 16. yüzyılın sonlarına doğru ya da 17. yüzyılın ilk yarısında yazıldığını tahmin ettiğimiz ve Sa‘dî adında kimliği tespit edilemeyen bir müellif tarafından kaleme alınan Tercüme-i Hilye-i Şerîf adlı eserdir. Elimizde bulunan tek nüshanın istinsah tarihi 1078/1667-68’dir.
Bu çalışmada Tercüme-i Hilye-i Şerîf, çeşitli yönlerden incelenmiş ve böylece mensur hilyelerin genel özelliklerine yönelik tespitlerde bulunulması amaçlanmıştır. Çalışmanın sonuna transkripsiyonlu metin eklenmiştir. İlgili kütüphanede eserin müellifinin Şeyhülislam Sa‘dî Çelebi, Sadullah b. Îsâ b. Emirhan El-Kastamonî er-Rûmî (öl. 945/1538) olarak gösterilmesinin yanlış olduğuna işaret edilmiştir.
A differentiated approach to complex treatment of radioiodine-induced salivary gland lesions
Authors: Kopchak A. V. , Makarenko V. А. 
Published: December 2023

The number of patients treated with radioactive iodine for highly differentiated thyroid carcinomas who develop chronic radiation-induced salivary gland lesions is constantly rising, that necessitates the search for new pathogenetically focused approaches and methods of treatment considering the stage of the process and pre-existing risk factors.
Aim. The aim of the study was to determine the clinical effectiveness of a new pathogenetic therapy based on a differentiated and personalized approach compared to standard approaches for radioactive iodine-induced salivary glands lesions.
Materials and methods. The prospective study included 60 patients (5 men and 55 women, aged 45.0 ± 0.5 years) with chronic radioactive iodine-induced salivary gland lesions following radiation treatment. The patients were divided into 2 groups depending on the type of therapy they received. The clinical effectiveness of the developed methods was evaluated with the use of objective clinical criteria within a year after radioiodine therapy.
Results. Our approach demonstrated reliably improved treatment outcomes compared to standard techniques. Thus, the treatment we offered, which included long-acting glucocorticoids, proteolysis inhibitors, and sialendoscopic techniques, completely resolved or minimized the clinical manifestations of the disease in 73.3 % of patients (33.3 % in the control group) one year after the start of treatment. The therapeutic effect was not found only in 6.7 % of patients compared to 20.0 % in the control group.
The developed approach effectively eliminated saliva outflow disorders and inflammatory symptoms, with significantly better results of the treatment group compared to the control group (χ2 = 6.20; p < 0.05 and χ2 = 6.67; p < 0.05). The disorders of secretory function were more difficult to correct, especially in the later stages of the disease, associated with severe xerostomia development.
Conclusions. The differentiated use of the developed pathogenetically oriented complex treatment enabled us to significantly improve the condition of patients with chronic radiation-induced sialoadenitis during the observation period of up to 1 year. This treatment also outperformed traditional symptomatic correction in solving the problem of saliva retention (χ2 = 6.67; p < 0.05) and inflammation manifestations (χ2 = 6.20; p < 0.05). Clinical symptoms of the disease were fully resolved or reduced in 73.3 % of patients versus 33.3 % in control group and partially improved in 20.0 % versus 46.0 % of control group within 12 months after radiation exposure. Longterm treatment and strict adherence to lifestyle and oral hygiene recommendations were required to achieve the desired clinical result and stable remission of clinical symptoms in patients with chronic radiation sialoadenitis.
THE INFLUENCE OF THE BOTANICAL AND GEOGRAPHICAL ORIGIN OF HONEY ON ITS MINERAL COMPOSITION
Authors: Аношкина О.В. , Лапынина Е.П. , Попкова М.А. 
Published: December 2023

Проблема и цель. Цель настоящих исследований состояла в изучении влияния ботанического и географического происхождения меда на его минеральный состав. Методология. Исследования проводились в ФГБНУ «Федеральный научный центр пчеловодства». Изучен состав более двадцати образцов цветочного меда различного ботанического и географического происхождения на содержание 10 элементов, в том числе тяжелых металлов. Результаты. В результате исследований выявлена зависимость минерального состава меда от количественного и качественного состава пыльцы, присутствующей в меде. Проведенные исследования наглядно показали, что фильтрация меда от пыльцевых зерен приводит к значительному уменьшению концентрации минеральных веществ, в среднем – на 85 %. Заключение. В ходе исследований было установлено, что ботаническое и географическое происхождение меда значительно влияет на его минеральный состав. Получены материалы для пополнения базы данных исследований элементного состава медов различного происхождения.
The purpose of these studies was to study the influence of the botanical and geographical origin of honey on its mineral composition. Methods. The research was conducted at the FSBCI "Federal Beekeeping Research Centre". The composition of more than twenty samples of flower honey of various botanical and geographical origin was studied for the content of 10 elements, including heavy metals. Results. As a result of the research, the dependence of the mineral composition of honey on the quantitative and qualitative composition of pollen present in honey was revealed. The conducted studies have clearly shown that the filtration of honey from pollen grains leads to a significant decrease in the concentration of minerals, on average by 85 %. Conclusion. In the course of research, it was found that the botanical and geographical origin of honey significantly affects its mineral composition. Materials have been obtained to replenish the database of studies of the elemental composition of honey of various origins.
Teatry kresowe na dawnych pocztówkach ze zbioru Jarosława Komorowskiego
Authors: Komorowski (oprac.) Jarosław 
Published: December 2023

Pocztówki stanowią ważną część ikonografii teatralnej. Szczególnie w odniesieniu do budynków, które już nie istnieją lub zostały znacznie przebudowane, takie dokumenty mają nieocenioną wartość. Podobnie jest z uwiecznionymi na pocztówkach scenami przedstawień czy spektakli: o wielu z nich nie wiedzielibyśmy nic, gdyż nie zostały utrwalone w żaden inny sposób. Prezentowane tu pocztówki zostały wyselekcjonowane z kolekcji dotyczącej budynków teatralnych na Kresach Wschodnich. Wybór obejmuje zarówno stałe siedziby zespołów teatralnych, jak i sale teatralne, w których występowały zespoły objazdowe i amatorskie.
Inversion of soil properties with hyperspectral reflectance in construction areas of high-standard farmland
Authors: Qiuxia Zhang , Wenkai Liu , Hebing Zhang , Xinsheng Wang , Shouchen Ma 
Published: December 2023

ABSTRACT

High-standard farmland construction is an important process that can enhance food security and accelerate new-style modernization agriculture. Hyperspectral remote sensing can provide data and technical support for this type of construction to provide a reference when optimizing high-standard farmland construction areas. This study was performed in Xinzheng City, the primary grain-producing areas in Henan Province. Field sampling and indoor hyperspectral spectroscopy (350~2500 nm) were combined; spectral transformations such as continuum removal (CR) were performed after Savitzky‒Golay (SG) convolution smoothing; and the best hyperspectral bands were selected as the common index of the soil properties by correlation analysis and fuzzy clustering maximum tree. A hyperspectral inversion model was built for the panel data model of the fixed effect variable coefficient based on the ordinary least squares estimation method (OLS), including panel data describing pH, organic matter, nitrogen, phosphorus, potassium, iron, chromium, cadmium, zinc, copper, and lead of 116 samples in Xinzheng City. Results show that the panel data model is of good quality overall, and the goodness of fit is higher (
R
2
= 0.9991, F = 2195.67). The precision test results indicate that the models performed well at both description and prediction, including accurate quantification, with an RPD above 2.5. Thus, the proposed model provides an important basis for soil information management, resource evaluation, and a reference when optimizing high-standard farmland construction processes.
Development of the concept of an intelligent system of environmental safety of the Northern Sea Route
Authors: Малыгин И.Г. , Коновалов И.Н. , Королев О.А. 
Published: December 2023

В данной статье исследуется перспектива развития представленной в предшествующих публикациях концепции Интеллектуальной системы экологической безопасности (ИСЭБ) с учетом последних достижений в области новых интеллектуальных и сетевых технологий и актуальной оценки текущего контекста, связанного с развитием Северного морского пути (СМП) и его использованием. Авторы статьи провели аналитическое исследование перспективных технологических инноваций, которые способны усовершенствовать и оптимизировать функциональность ИСЭБ. Эти усовершенствования направлены на усиление системной способности к интеграции с государственными интеллектуальными системами других профилей, расширение возможностей системы в области стратегического планирования деятельности СМП, прогнозирования и анализа экологических рисков, разработки методов и подходов для их минимизации, а также выработки стратегий реагирования на изменения показателей мониторинга и возможные чрезвычайные события и катастрофы различного характера. Кроме того, статья затрагивает вопросы построения сетей экологических зондов. Дополнительно в работе проведена систематизация потенциальных экологических вызовов, связанных с дальнейшим развитием Северного морского пути и ассоциированными территориями Арктической зоны Российской Федерации (АЗ РФ).
This article examines the prospects for the development of the concept of an Intelligent Environmental Safety System (ISEB) presented in previous publications, taking into account the latest achievements in the field of new intelligent and network technologies and an up-to-date assessment of the current context associated with the development of the Northern Sea Route (NSR) and its use. The authors of the article conducted an analytical study of promising technological innovations that can improve and optimize the functionality of the ISEB. These improvements are aimed at strengthening the system's ability to integrate with state intellectual systems of other profiles, expanding the system's capabilities in the field of strategic planning of the activities of the NSR, forecasting and analyzing environmental risks, developing methods and approaches to minimize them, as well as developing strategies to respond to changes in monitoring indicators and possible emergency events and disasters of various nature. In addition, the article touches on the issues of building networks of environmental probes. Additionally, the work systematizes potential environmental challenges associated with the further development of the Northern Sea Route and associated territories of the Arctic zone of the Russian Federation (AZ RF).