bluuebunny/crossref_metadata_2025_split huggingface dataset:
PERBEDAAN TINGKAT JENIS PERMOHONAN LAYANAN DARI PANDEMI DAN SESUDAH PANDEMI PADA BADAN PERTANAHAN NASIONAL ACEH TAMIANG
Authors: Indri Indriyani 
Published: November 2023

ABSTRAK

Tingkat pelayanan jenis permohonan di bidang pertanahan kepada masyarakat merupakan salah satu bagian dari pelayanan umum oleh pemerintah kepada masyarakat. Dalam membantu masyarakat untuk memiliki Hak-hak atas tanah, BPN membentuk program kerja dengan jenis permohonan pelayanan dengan segala urusan atas hak tanah. Data yang digunakan adalah data sekunder yaitu jumlah layanan jenis permohonan pada masa pandemi dan sesudah pandemi di Kantor Pertanahan Aceh Tamiang. Data yang bersumber dari instansi Kantor Badan Pertanahan Nasional Kabupaten Aceh Tamiang. Data yang didapat dari BPN Kabupaten Aceh Tamiang di analisis menggunakan perbandingan rata-rata pada SPSS. Tujuan Penelitian ini adalah untuk mengetahui perbedaan layanan jenis permohonan pada masa pandemi dan sesudah pandemi di kantor Badan Pertanahan Aceh Tamiang Berdasarkan analisis yang dilakukan di dapat tidak ada perbandingan rata-rata yang signifikansi layanan jenis permohonan pada masa pandemi dan sesudah pandemi pada Kantor Pertanahan Aceh Tamiang. Jumlah keseluruhan rata-rata untuk layanan jenis permohonan pada masa sesudah pademi lebih besar yaitu 44,70 layanan dari pada jumlah keseluruhan rata-rata layanan jenis permohonan pada masa pandemi yaitu sebesar 31,80 layanan. Hal ini menyatakan bahwa pada masa sesudah pandemi jenis layanan permohonan masyarakat dalam mengurus hak tanah pada Kantor Pertanahan Aceh Tamiang sudah lebih baik dari pada layanan pada masa pandemi. Hal tersebut dikarenakan sudah adanya tindakan pemerintah untuk mengatasi kegiatan dalam masa pandemi.
Kata kunci : Jenis Layanan Permohonan, Perbandingan Rata-rata
FORECASTING PENINGKATAN JUMLAH PENDUDUK MISKIN KABUPATEN LANGKAT MENGGUNAKAN METODE EXPONENTIAL SMOOTHING
Authors: RAMADANI INDAH 
Published: November 2023

ABSTRAK
Kemiskinan merupakan salah satu persoalan mendasar, karena kemiskinan menyangkut pemenuhan kebutuhan yang paling mendasar dalam kehidupan dan kemiskinan merupakan masalah global karena kemiskinan merupakan masalah yang dihadapi banyak negara. Di samping itu kemiskinan juga berkaitan dengan keterbatasan lapangan pekerjaan dan biasanya mereka yang dikategorikan miskin (the poor) tidak memiliki pekerjaan (pengangguran), serta tingkat pendidikan dan kesehatan mereka pada umumnya tidak memadai. Tujuan dari penelitian ini adalah untuk mengetahui pengaplikasian metode exponential smoothing dalam peramalan jumlah penduduk miskin di Kabupaten Langkat tahun 2022-2025. Data yang digunakan adalah data tahunan dengan jenis data adalah data sekunder yang diperoleh dari Badan Pusat Statistik (BPS) Kabupaten Langkat. Metode peramalan yang tepat digunakan adalah double exponential smoothing, dengan menggunakan dua parameter yaitu ???? = 0,9 ???????????? ???? = 0,6. Hasil forecasting dengan metode ini pada tahun 2022-2024 berturut-turut 107.440, 109.020, 110.610, dan 112.200. Dalam hal ini hasil forecasting mengalami penaikan secara terus-menerus setiap tahunnya.
Kata kunci : Kemiskinan, metode exponential smoothing, forecasting,
stasioner, trend, musiman.
Mechanical, chemical and biological properties of PLA 3D printer: A systematic review
Authors: Lodi Heloisa Domingues , Campos Murilo Rodrigues de , Reis Andréa Cândido dos 
Published: November 2023

The aim of this systematic review is to evaluate, through the in vitro studies included, whether PLA has mechanical, chemical and biological properties that enable its clinical use in dentistry. An electronic search was carried out in the Pubmed, Science Direct, Embase and Scopus databases containing the terms ''polylactic acid'', ''3D printing'',''biomaterials'',''dental materials'', dental prosthesis and dentistry. The objective of the inclusion criteria was to cover articles written and published in English that focused on the use of PLA in the field of dental materials and biomaterials printed using the 3D method. Any articles that did not focus on the study of PLA polymer, as well as systematic reviews, book chapters, abstracts, letters and conference articles were excluded. 1814 references were found, which after applying the exclusion criteria resulted in the final inclusion of 13 articles for the review. Based on the studies included in this systematic review, it is possible to conclude that 3D printed PLA used as a dental material and biomaterial presents favorable mechanical, chemical and biological properties that indicate its potential clinical use.
Avaliação do tempo de efervescência de comprimidos de vitamina C em amostras de água com diferentes durezas
Authors: Costa Fernanda Michele Oliveira da , Fonseca Fernanda Santos da , Freitas Paulo Mateus Rodrigues , Lobão Yasmin Bitelli , Giorgetti Leandro , Michelin Luis Felipe Gomes 
Published: November 2023

Este estudo teve como objetivo investigar o tempo de efervescência do comprimido de vitamina C (ácido ascórbico) em águas de diferentes durezas. Foram avaliadas três marcas com concentração de 1 grama de vitamina C em duas amostras de água de dureza de 71,4 ppm (moderadamente dura) e 232 ppm (muito dura). Duas hipóteses foram levantadas sobre os possíveis impactos que a dureza da água teria na efervescência dos comprimidos: a primeira relacionava o pH da água dura e sua influência na tensão superficial da água, e a segunda relacionava a possibilidade da reação dos íons presentes na água com as substâncias constituintes do comprimido. O método empregado para a determinação da dureza total foi o teste MQuant®, e as duas amostras de água apresentaram dureza de 71,4 e 232 ppm. Em seguida, os tempos de desintegração dos comprimidos foram obtidos e comparados através do método de Tukey. Não houve diferenças significativas entre as amostras analisadas. Este trabalho reforça que são necessárias pesquisas adicionais sobre a relação da dureza da água com a efervescência de comprimidos de vitamina C, o que ajuda a compreender como a relação da qualidade da água pode afetar a utilização de medicamentos efervescentes.
ANALISIS FAKTOR YANG MEMPENGARUHI KESTABILAN GULA DARAH PENDERITA DIABETES MELLITUS PADA USIA DEWASA DAN LANSIA
Authors: Setianto Andi , Maria Lilla , Firdaus Achmad Dafir 
Published: November 2023

Penyakit DM ditandai dengan ketidakstabilan gula darah tubuh karena adanya gangguan pengeluaran insulin. Pemberian terapi pada pasien DM perlu memperhatihan faktor-faktor yang mempengaruhi kestabilan gula darah, sehingga pemberian terapi akan lebih efektif dan akurat sesuai dengan kebutuhan penderita DM. Tujuan penelitian ini adalah untuk mengetahui faktor apasaja yang mempengaruhi kestabilan gula darah penderita DM pada usia dewasa dan lansia. Penelitian ini adalah studi tinjauan pustaka dengan menggunakan beberapa strategi pencarian literature yaitu menggunakan framework PICOS, pencarian keywords (gula darah, diabetes mellitus, faktor, dewasa, lansia), dan pencarian pada database (Ebsco, PubMed, CAB Direct. Faktor-Faktor yang mempengaruhi kestabilan gula penderita DM pada usia dewasa dan lansia adalah data demografi, pola makan, aktivitas fisik, lama terdiagnosa DM, pengetahuan penderita DM, penyakit penyerta dan komplikasi, jenis dan kepatuhan pemberian terapi antidiabetes. Faktor yang paling berpengaruh terhadap kestabilan gula darah adalah lama terdiagnosa penyakit DM.
PENGARUH KOMBINASI ANTIBAKTERI EKSTRAK BUNGA TELANG (Clitoria ternatea L.) DAN LIDAH BUAYA (Aloe vera) TERHADAP PERTUMBUHAN PROPIONIBACTERIUM ACNES
Authors: Khairunnisa Nadhira Izdihar 
Published: November 2023

Latar belakang: Propionibacterium acnes berperan penting dalam akne vulgaris. Terhitung sebanyak 80-85% angka kejadian akne vulgaris di Indonesia. Pengunaan antibiotik sering menyebabkan resistensi. Antibiotik dari bahan alami menjadi salah satu alternatif, salah satunya Bunga Telang (Clitoria ternatea) dan Lidah Buaya (Aloe vera) yang memiliki aktivitas antibakteri. Kombinasi ekstrak telah terbukti memiliki efek sinergisme dibandingkan dengan ekstrak tunggal.
Tujuan: Mengetahui pengaruh kombinasi ekstrak Bunga Telang (Clitoria ternatea L.) dan Lidah Buaya (Aloe vera) terhadap pertumbuhan bakteri Propionibacterium acnes.
Metode: Penelitian ini menggunakan metode true experimental dengan posttest only control group design. Menggunakan sampel bakteri Propionibacterium acnes dan metode dilusi tabung dengan 6 konsentrasi Bunga Telang dan Lidah Buaya 100%, 50%, 25%, 12,5%, 6,25%, 0%. Analisis data menggunakan uji T-Test.
Hasil: Pada Uji T-Test didapatkan hasil bahwa kombinasi ekstrak Bunga Telang dan Lidah Buaya pada konsentrasi 6,25% memiliki perbedaan yang signifikan.
Kesimpulan: Kombinasi ekstrak Bunga Telang (Clitoria ternatea) dan Lidah Buaya (Aloe vera) memiliki pengaruh dalam menghambat pertumbuhan Propionibacterium acnes.
RECONSTRUCTIVE SURGERY OF POST-RESECTION DEFECTS OF THE UPPER JAW
Authors: Magomedova Kh. M. , Sletova V. A. , Gandylyan K. S. , Gabbasova I. V. , Kononenko V. I. , Idrisova A. M. , Sletov A. A. 
Published: November 2023

Post-resection defects of the upper jaw are one of the most difficult problems in surgery. They can occur after removal of tumors, trauma or infection, and can cause various functional and aesthetic problems in patients. Surgical reconstruction of the maxilla may require the use of bone grafts and/or implants, which may be ineffective or cause a number of complications in the absence of a reconstructive approach.The aim of the study was to assess the efficacy and safety of surgical reconstruction of the upper jaw using modified individual plates and bone autografts.Materials and methods. The study was conducted among 35 patients with post-resection defects of the upper jaw. All patients underwent surgical reconstruction using modified individual plates and revascularizable autografts, according to the division into 2 groups. Evaluation of the effectiveness of the reconstruction was carried out based on clinical data in the early and late postoperative periods.Results. The use of revascularized flaps makes it possible to achieve an optimal long-term result with the absence of a large volume of foreign bodies in the recipient bed.Conclusions. Reconstructive surgery using metal structures is fraught with a number of postoperative complications that require corrective manipulations and (or) a fundamentally different approach for repeated interventions. Currently, the gold alternative standard is the use of revascularized flaps, which allowed 16 patients to achieve a long-term stable result with the restoration of the continuity of the upper jaw, followed by prosthetics.
Docking and MM study of non-structural protein (NS5) of Japanese Encephalitis Virus (JEV) with some derivatives of adenosyl
Authors: Tiwari Rakesh Kumar , Pandey Vinayak , Srivastava Harshita , Srivastava Ambrish Kumar , Pandey Vishnudatt 
Published: November 2023

Introduction: The flavivirus NS5, a non-structural protein of Japanese Encephalitis Virus (JEV), a serious deadly human pathogen responsible for epidemics in South East Asia, consists of N-terminal methyl transferase (MTase) domain and RNA-dependent RNA polymerase (RdRp) is known for unique viral genome replication and cap formation activity. S-adenosyl executes a crucial function in these viral activities. S-adenosyl derivatives are chosen as potential binders with the MTase domain of NS5 based on MM and docking studies.Methods: MM GBSA (Generalized Born Surface Area) simulation were performed to evaluate the binding energy, following the 100 nanosecond (ns) production MD simulation in the periodic boundary condition (PBC) for the selected docked ligands with NS5. Quasi-harmonic entropy of the ligands was also calculated with semi-empirical calculations at the PM3/PM6 level supporting docking and MM-GBSA results.Results and discussion: The residue-wise decomposition energy reveals that the key hydrophobic residues Gly 81, Phe 133, and Ile 147 in the RdRp-MTase interface, indicate the biological relevance. These residues act as the key residue stabilizer, binding vigorously with S-Adenosyl derivatives in the vicinity of the interface between the MTase domain and RdRp. This paves the way for the other potential drug as an inhibitor for the enzymatic activity of the NS5.
Erythromycin, retapamulin, pyridoxine, folic acid, and ivermectin inhibit cytopathic effect, papain-like protease, and MPRO enzymes of SARS-CoV-2
Authors: Bello Shaibu Oricha , Imam Mustapha Umar , Bello Muhammad Bashir , Yunusa Abdulmajeed , Ahmed Adamu Adamu , Shuaibu Abdulmalik , Igumbor Ehimario Uche , Habib Zaiyad Garba , Popoola Mustapha Ayodele , Ochu Chinwe Lucia , Yahaya Bello Aishatu , Deeni Yusuf Yahaya , Okoye Ifeoma 
Published: November 2023

BackgroundAlthough tremendous success has been achieved in the development and deployment of effective COVID-19 vaccines, developing effective therapeutics for the treatment of those who do come down with the disease has been with limited success. To repurpose existing drugs for COVID-19, we previously showed, qualitatively, that erythromycin, retapamulin, pyridoxine, folic acid, and ivermectin inhibit SARS-COV-2-induced cytopathic effect (CPE) in Vero cells.AimThis study aimed to quantitatively explore the inhibition of SARS-CoV-2-induced CPE by erythromycin, retapamulin, pyridoxine, folic acid, and ivermectin and to determine the effect of these drugs on SARS-CoV-2 papain-like protease and 3CL protease (MPRO) enzymes.MethodsNeutral red (3-amino-7-dimethylamino-2-methyl-phenazine hydrochloride) cell viability assay was used to quantify CPE after infecting pre-treated Vero cells with clinical SARS-Cov-2 isolates. Furthermore, SensoLyte® 520 SARS-CoV-2 papain-like protease and SensoLyte® 520 SARS-CoV-2 MPRO activity assay kits were used to evaluate the inhibitory activity of the drugs on the respective enzymes.ResultsErythromycin, retapamulin, pyridoxine, folic acid, and ivermectin dose-dependently inhibit SARS-CoV-2-induced CPE in Vero cells, with inhibitory concentration-50 (IC50) values of 3.27 µM, 4.23 µM, 9.29 µM, 3.19 µM, and 84.31 µM, respectively. Furthermore, erythromycin, retapamulin, pyridoxine, folic acid, and ivermectin dose-dependently inhibited SARS-CoV-2 papain-like protease with IC50 values of 0.94 µM, 0.88 µM, 1.14 µM, 1.07 µM, and 1.51 µM, respectively, and inhibited the main protease (MPRO) with IC50 values of 1.35 µM, 1.25 µM, 7.36 µM, 1.15 µM, and 2.44 µM, respectively.ConclusionThe IC50 for all the drugs, except ivermectin, was at the clinically achievable plasma concentration in humans, which supports a possible role for the drugs in the management of COVID-19. The lack of inhibition of CPE by ivermectin at clinical concentrations could be part of the explanation for its lack of effectiveness in clinical trials.
Minimum clinically important differences in the Minnesota Living with Heart Failure questionnaire: from a study of heart failure patients treated with integrated Chinese and Western medicine
Authors: Zhu Yanbo , Cong Jianni , Lin Lin , Du Jinhang , Long Liqun , He Yuan , Ren Jiaju 
Published: November 2023

ObjectiveThe purpose of this study was to estimate the minimum clinically important differences (MCIDs) in the Minnesota Living with Heart Failure questionnaire (MLHFQ), which targeted patients with heart failure treated with integrated Chinese and Western medicine, as a means of helping doctors and patients judge the effectiveness of intervention.MethodsA total of 194 patients with chronic heart failure were recruited from three general hospitals in Beijing. Anchor-based and distribution-based approaches were used to estimate MCID. The anchor was SF-36 item 2 (HT, Health Transition), and the calculation methods included the mean change method, receiver operating characteristic (ROC) curve analysis, and linear regression model. For the distribution-based approaches, 0.2, 0.5, and 0.8 standardized response mean (SRM) values and standard error of measurement (SEM) value of 1 were used.ResultsThe correlation coefficients of the MLHFQ scale information and HT were 0.346–0.583. Different MCIDs were obtained by the mean change method, ROC curve, and linear regression model. The minimum MCID in the physical domain, emotional domain, and total scores were 3.6, 2.0, and 7.4, respectively; the maximum estimates were 9.5, 2.5, and 13.0, respectively; and the average estimates were 5.7, 2.2, and 10.0, respectively. The average estimates were close to the result of the 0.5 SRM or 1 SEM.ConclusionWe established MCIDs in the MLHFQ using anchor-based and distribution-based approaches. It was recommended to round the average estimates of anchor-based approaches up to the nearest whole number for the MCIDs of the MLHFQ physical domain, emotional domain, and total scores. The results were 6.0, 2.0, and 10.0, respectively.
Transition to a zero-carbon energy system in the Ningxia area: integrated CO2 reduction measures from the multi-level perspective
Authors: Qi Caijuan , Meng Jinyou , Che Bin , Kang Junjie , Zhao Yingtao , Hua Zhilei 
Published: November 2023

China’s commitment to decarbonization has become a foundational principle guiding policymaking at national, provincial, and local levels across diverse sectors. This commitment is especially evident in the active promotion of low-carbon energy transitions by all provinces, aligning with the national goal of carbon neutrality. This paper focuses on Ningxia Province and constructs five scenarios for low-carbon energy transition, adopting the multi-level perspective. These scenarios include the business-as-usual scenario (BAU), high electrification scenario (HES), high outward electricity scenario (HOS), low carbon scenario (LCS), and energy saving scenario (ESS). Utilizing the LEAP-Ningxia model, we simulate energy demand across various sectors until 2060. The quantitative analysis covers primary energy production, secondary energy conversion, final energy consumption, and CO2 emissions. Notably, under scenarios incorporating carbon capture and storage (CCS) and carbon credits, the total CO2 emissions in Ningxia are projected to decrease to 17∼23 Mt CO2 until 2060 under BAU, HES, and HOS. In LCS and ESS, a remarkable achievement is forecasted with 6∼93 Mt CO2 of negative emissions from the energy sector in Ningxia until 2060. The findings underscore the importance of diverse CO2 reduction measures and their impacts on achieving a zero-carbon energy transition in Ningxia. The implications of scenarios with CCS and carbon credits showcase significant reductions in CO2 emissions, aligning with China’s broader decarbonization goals. The results provide valuable scientific support and insights for policymakers and stakeholders involved in steering Ningxia towards a sustainable and low-carbon future.
Rapid transient and longer-lasting innate cytokine changes associated with adaptive immunity after repeated SARS-CoV-2 BNT162b2 mRNA vaccinations
Authors: Rosati Margherita , Terpos Evangelos , Homan Philip , Bergamaschi Cristina , Karaliota Sevasti , Ntanasis-Stathopoulos Ioannis , Devasundaram Santhi , Bear Jenifer , Burns Robert , Bagratuni Tina , Trougakos Ioannis P. , Dimopoulos Meletios A. , Pavlakis George N. , Felber Barbara K. 
Published: November 2023

IntroductionCytokines and chemokines play an important role in shaping innate and adaptive immunity in response to infection and vaccination. Systems serology identified immunological parameters predictive of beneficial response to the BNT162b2 mRNA vaccine in COVID-19 infection-naïve volunteers, COVID-19 convalescent patients and transplant patients with hematological malignancies. Here, we examined the dynamics of the serum cytokine/chemokine responses after the 3rd BNT162b2 mRNA vaccination in a cohort of COVID-19 infection-naïve volunteers.MethodsWe measured serum cytokine and chemokine responses after the 3rd dose of the BNT162b2 mRNA (Pfizer/BioNtech) vaccine in COVID-19 infection-naïve individuals by a chemiluminescent assay and ELISA. Anti-Spike binding antibodies were measured by ELISA. Anti-Spike neutralizing antibodies were measured by a pseudotype assay.ResultsComparison to responses found after the 1st and 2nd vaccinations showed persistence of the coordinated responses of several cytokine/chemokines including the previously identified rapid and transient IL-15, IFN-γ, CXCL10/IP-10, TNF-α, IL-6 signature. In contrast to the transient (24hrs) effect of the IL-15 signature, an inflammatory/anti-inflammatory cytokine signature (CCL2/MCP-1, CCL3/MIP-1α, CCL4/MIP-1β, CXCL8/IL-8, IL-1Ra) remained at higher levels up to one month after the 2nd and 3rd booster vaccinations, indicative of a state of longer-lasting innate immune change. We also identified a systemic transient increase of CXCL13 only after the 3rd vaccination, supporting stronger germinal center activity and the higher anti-Spike antibody responses. Changes of the IL-15 signature, and the inflammatory/anti-inflammatory cytokine profile correlated with neutralizing antibody levels also after the 3rd vaccination supporting their role as immune biomarkers for effective development of vaccine-induced humoral responses.ConclusionThese data revealed that repeated SARS-Cov-2 BNT162b2 mRNA vaccination induces both rapid transient as well as longer-lasting systemic serum cytokine changes associated with innate and adaptive immune responses.Clinical trial registrationClinicaltrials.gov, identifier NCT04743388.
Development of an autoantibody panel for early detection of lung cancer in the Chinese population
Authors: Tong Lin , Sun Jiayuan , Zhang Xiaoju , Ge Di , Li Ying , Zhou Jian , Wang Dong , Hu Xin , Liu Hao , Bai Chunxue 
Published: November 2023

IntroductionTumor-associated autoantibodies have been revealed as promising biomarkers for the early detection of lung cancer. This study was designed to develop an autoantibody panel for early detection of lung cancer in the Chinese population.MethodsRecruited prospectively in three clinical centers, the subjects (n = 991) who had a definite diagnosis during follow-up were included in the development of the autoantibody panel. The levels of 14 autoantibody candidates in plasma were detected.ResultsA panel of nine autoantibody markers (named as CN9), namely, P53, SOX2, SSX1, HuD, NY-ESO-1, CAGE, MAGE-A4, P62, and CK20, was preferably selected from 14 candidates. The overall specificity, sensitivity, and AUC were 90.5%, 40.8%, and 0.64, respectively. The CN9 panel demonstrated a reasonable detection rate in lung cancer patients at all stages, histological types, sizes of lesions, and risk levels. Its estimated overall accuracy is 85.5% and 90%, with PPV at 0.32 and 0.04, and NPV at 0.93 and 0.99 in the scenario of pulmonary nodules' characterizing and lung cancer screening, respectively. Two risk models were developed within the subgroups of malignant and benign pulmonary nodules in this study. By adding the CN9 result to the Mayo model indicators, it achieved a sensitivity of 41.3% and an AUC of 0.74 at a specificity of 91.3%. By adding the CN9 result to the Brock model indicators, it achieved a sensitivity of 47.7% and an AUC of 0.78 at a specificity of 91.3%. Both were improved compared with either the standalone Mayo or Brock model.DiscussionThis multi-center prospective study indicates a panel of nine autoantibody markers that can help in the detection of lung cancer and the classification of pulmonary nodules in the Chinese population.