bluuebunny/crossref_metadata_2025_split huggingface dataset:
The Potential of Cyperus rotundus L. As a Natural Hair Removal Agent: A Review of Traditional and Modern Applications
Authors: Mohammed Ghada Farouk , Al‐Dhubaibi Mohammed Saleh , Bahaj Saleh Salem , AbdElneam Ahmed Ibrahim , Al‐Dhubaibi Ahmed Mohammed , Atef Lina Mohammed 
Published: January 2025

ABSTRACTIntroductionHair removal is a fundamental aspect of daily life, with various hair removal methods evolving throughout hair removal history to meet cultural, aesthetic, and spiritual needs. Traditional hair removal practices have long sought effective hair removal products that not only remove hair but also promote skin health. Cyperus rotundus L. (Cr L.), known as nut grass or purple nut sedge, has long been used in traditional medicinal systems like Ayurveda and Traditional Chinese Medicine (TCM) for treating various ailments, including skin conditions and depilation.AimTo understand the role of Cr L. in decreasing hair growth.ResultsCr L. contains essential oils (EOs) and phytochemicals such as flavonoids, alkaloids, and saponins, which contribute to its hair‐removal properties. These compounds target hair follicles, dissolve keratin, and inhibit hair regrowth by modulating biological pathways. γ‐curcumene, a key component, has been shown to suppress hair growth. Recent clinical trials have demonstrated the efficacy of Cyperus rotundus EO (CREO) in reducing hair growth, with minimal side effects. CREO has been found as effective as Alexandrite laser treatments in some cases, particularly in reducing white hair. This positions Cr L. as a promising natural alternative to chemical depilatories, which often cause skin irritation.ConclusionCr L. shows significant potential as a natural hair removal agent. With its strong safety profile and growing consumer demand for natural, sustainable beauty products, Cr L. could serve as a viable alternative to synthetic depilatories, pending further clinical validation.
From Play Date to Stress Fate: Juvenile Social Play Rescues Stress‐Induced Changes in Adult Social Behavior
Authors: Whitten Conner J. , Kelly Jeffrey R. , Gillespie Alex L. , Brooks Heather J. B. , Hooker Mackenzie K. , Temple Anna R. , Hennon Leila M. , Kilgore Benjamin J. , Singamaneni Yaswanth B. , Schulz Kalynn M. , Burghardt Gordon M. , Cooper Matthew A. 
Published: January 2025

ABSTRACTLong‐term effects of social play on neural and behavioral development remain unclear. We investigated whether just 1 h of juvenile social play could rescue the effects of play deprivation on stress‐related behavior and markers of neural plasticity. Syrian hamsters were reared from postnatal days 21–43 in three conditions: peer isolation, peer isolation with daily social play sessions (dyadic play), or group‐housed with littermates. In adulthood, subjects were exposed to acute social defeat stress, and we examined changes in perineuronal net (PNN) expression surrounding parvalbumin (PV) neurons in the prelimbic (PL), infralimbic (IL), and basolateral amygdala (BLA). Peer deprivation led to exaggerated submissive and defensive behavior in a conditioned defeat test, but 1 h of dyadic play rescued the heightened conditioned defeat response in both males and females. In females, play deprivation reduced PNN/PV coexpression in the PL and IL compared to control groups with opportunities for social play. Males exposed to peer isolation showed elevated agonistic behavior when returned to their littermates compared to males exposed to 1‐h play encounters. These findings indicate juvenile social play has long‐lasting effects on PNN expression surrounding PV cells in the medial prefrontal cortex, which allows for the development of species’ typical agonistic behavior and greater stress resistance in adulthood. The ability of just 1 h of social play to rescue the effects of peer isolation highlights the powerful role of social interactions in neural and behavioral development.
Potential Distribution Prediction of Terminalia chebula Retz. in China Under Current and Future Climate Scenarios
Authors: Dong Zhang‐Hong , Jiang Hua , Zhang Wei , Wu Jianhua , Yang Yanping , Yang Taoming , Zhao Jiangping , Luo Cunzhen , Yang Xiaoxia , Li Guilin 
Published: January 2025

ABSTRACTClimate change in the future could potentially expand, shrink, or alter the habitats of numerous species, leading to changes in their spatial distributions. Predicting suitable areas for cultivating medicinal plants through modeling has become an effective tool for assessing site suitability and conserving medicinal plant resources. Utilizing GIS and MaxEnt model, we predicted the spatial distribution of Terminalia chebula Retz. in China for the current and for the future (2050s and 2070s) under the RCP4.5 and RCP8.5 representative concentration pathways. In this study, we utilized 73 occurrence records and incorporated eight environmental factors from WorldClim for the modeling process. The findings revealed that the evaluation of the model's performance was based on the area under the curve (AUC) of the receiver operating characteristic (ROC). All AUC values exceeded 0.9, classifying these models as “Excellent.” Additionally, the jackknife test analysis revealed that the main influential variables were bio11 and bio4. Under the present climate conditions, the estimated total suitable habitat for T. chebula is approximately 29.14 × 104 km2, representing around 2.78% of China's total land area. Within these suitable regions, high suitability, medium suitability, and low suitability areas make up 0.39%, 0.54%, and 1.85% of the total area, respectively. According to future climate, the potential growth range of T. chebula is expected to expand due to climate variability, showing a significant pattern of expansion towards the north and east within China. In the 2050s and 2070s, the total area of regions with high suitability, medium suitability, and low suitability under RCP4.5 and RCP8.5 will increase compared to the current distribution. This study will provide theoretical suggestions for preservation, management, and sustainable utilization of T. chebula resources.
Feeding Habits of Leopards and Leopard Cats in the Fragmented Forests Surrounding the Kathmandu Valley
Authors: Manandhar Prajwol , Pereira Keren S. , Kusi Naresh , Joshi Jyoti , Levin Noam , Chaudhary Hemanta K. , Wultsch Claudia , Lamichhane Sandesh , Bhandari Suman , Guragain Laba , Rajbhandari Rajesh M. , Rensburg Berndt J. V. , Kark Salit , Karmacharya Dibesh 
Published: January 2025

ABSTRACTLarge‐scale anthropogenic developments in the metropolitan areas of Nepal and the rural to urban influx of people have exacerbated human–wildlife conflicts across human‐altered landscapes of Nepal. The Kathmandu Valley has experienced large‐scale urbanization and has subsequently witnessed substantial incidents of human–wildlife conflicts given the increasing levels of human encroachment into remnant wildlife habitats. Here, we applied DNA metabarcoding in combination with geospatial analysis to study the feeding ecology of two urban carnivores, the leopard (Panthera pardus) and the leopard cat (Prionailurus bengalensis), in the forests surrounding the Kathmandu Valley and to check whether the leopards' predation on domestic animals contributes to human‐leopard conflict in this region and to obtain a baseline data on the dietary habits of the poorly studied leopard cat. We found that leopards were highly dependent on domestic animals in areas dominated by human‐use activities (agricultural and built‐up areas), whereas leopard cats mostly predated on wild rodents. Through our work, we highlight the importance of domestic prey in the diets of urban carnivores like leopards and demonstrate the influence human‐induced habitat disturbance has on the ecology of local wildlife. This study generates critical information which will help to inform conflict mitigation strategies and conservation planning for the two carnivore species, in addition to identifying areas within the region that are susceptible to human–wildlife conflicts.
Cannabinoids for Acute Postoperative Pain Management: A Systematic Review and Meta‐Analysis of Clinical Trials
Authors: González Cárdenas Víctor Hugo , Valdivieso Díaz Mariafernanda , Mateus Almeciga Carlos Felipe , Echeverry Carrillo Juan Carlos , López Trujillo Juan Carlos , Hernández Arenas Angela Rocío , Paternina Rojas Jorge Luis 
Published: January 2025

ABSTRACTBackgroundPoor acute postoperative pain control, coupled with the use of intravenous medications with a limited and unsafety efficacy spectrum, has led to new therapeutic alternative explorations to reduce adverse events while increasing its analgesic efficacy. There cannabinoids have been proposed as a useful control agent in post‐surgical pain. Nevertheless, to date, there is no solid evidence to evaluate them. The current article sought to determine cannabinoids' effectiveness and safety in the aforementioned context.MethodsA systematic review of controlled clinical trials evaluated the efficacy and safety of cannabinoids for the treatment of acute postoperative pain. The study was structured under the Cochrane recommendations. Primary outcomes included: pain intensity reduction, the number and doses of rescue analgesics and adverse events.ResultsOf 62 articles found, only five were included. Four of them presented high inter‐observer agreement and 60% were classified as having a low risk of bias. When evaluating the objectives of each article, a disparity was found in the investigative methods and terms implemented. Due to the heterogeneity of methods, it was not possible to carry out meta‐analytic evaluations and only qualitative evaluations were feasible.ConclusionsDespite finding contradictory evidence in relation to the analgesic cannabis effect in the postoperative context, methodological disparities found in the included articles and the impossibility of performing collective quantitative analyses were more significant. Before concluding with the well‐known sentence: “further intervention studies are necessary”, this report has identified limitations and has proposed recommendations for the planning and execution of future cannabis clinical trials, which will support new and necessary evidence for stronger meta‐analytic reviews.SignificanceThe management of severe pain after surgery, and the use of intravenous drugs with limited and potentially unsafe effectiveness, has led to the exploration of new treatment options to minimize side effects while improving pain relief. Cannabinoids have been suggested as a potential solution for managing post‐surgical pain, but there is currently insufficient evidence to assess their effectiveness. The purpose of this article was to evaluate the effectiveness and safety of cannabinoids in this context.
Fatalism, Evolution, and Interpersonal Attractiveness: Psychological Theories and Emotions in Incels' Constructions of Ingroup Identity and Outgroup Hate
Authors: Pettersson Katarina , Marveggio Mark Daniel , Callaghan Peta , Augoustinos Martha 
Published: January 2025

ABSTRACTThe online communities of involuntary celibates, or incels, have garnered increased attention for their extreme misogyny and links to violent attacks against women. However, little is known about how (pseudo‐)psychological theories are used among the incel community to construct their identities and justify a worldview that centres on hatred against women. This study uses a critical discursive psychological approach to examine identity constructions in discussions on the so‐called blackpill worldview within the online community incels.is. Our analysis of more than 1000 discussion threads written in 2020 reveals three distinct incel identities: incels as victimised martyrs, incels as aggrieved masculine actors, and a divided identity negotiating the boundaries of ‘pure’ and ‘impure’ inceldom. These identities are constructed through psychological notions, specifically, fatalism, ‘just‐world’ beliefs, evolutionary psychology, eugenics and theories of interpersonal attraction—that serve as interpretative repertoires expressed through a plethora of rhetorical strategies and affective–discursive practices. The study highlights the importance of understanding how psychological concepts are appropriated in the construction of ingroup identities and justifications of outgroup hate within misogynist online communities.
Key Technologies for Horizontal Well Development in Deep Tight Sandstone Reservoirs
Authors: Guan Yiting , Cheng Xin , Chen Xiaoyang 
Published: January 2025

ABSTRACTDeep tight sandstone oil and gas reservoirs are exerting an increasingly crucial role in the augmentation of fossil energy reserves and the provision of energy. On account of the intricate geological conditions and the deficiency of a comprehensive set of exploration and development engineering technologies as well as supporting processes, the present development of deep tight sandstone oil and gas reservoirs remains in its nascent stage. Through the analysis and generalization of the horizontal well development technology for deep tight sandstone oil and gas reservoirs, a series of technologies have been established, encompassing reservoir geological evaluation and modeling, horizontal well development reservoir engineering validation, horizontal well geological design, and enhanced oil recovery processes. By taking the C 6 reservoir in Ordos basin, China as the research subject, in light of the research outcomes regarding the damage mechanisms and potential damage factors of tight sandstone oil and gas reservoirs, a geological evaluation approach based on the well log response characteristics was constructed, clarifying the porosity and permeability features of the C 6 reservoir, establishing the numerical model of the oil reservoir, and further elaborating the methods for dividing the development layers, selecting the development well pattern, and determining the development well density. The design parameters of horizontal well‐segmented hydraulic fracturing were meticulously optimized, resulting in a minimum cluster spacing of 7 m and a maximum cluster spacing of 20 m. Given the influence of horizontal stress differences, the optimum fracturing density was ascertained to be 16 perforations per meter, and the optimal fracturing fluid volume was identified through simulation to range from 12 to 25 m3/m. The crucial technologies for the development of tight sandstone oil and gas reservoirs in horizontal wells have been clearly identified, offering theoretical direction for the efficient exploitation of deep tight sandstone oil and gas reservoirs.
Erosion rates for forest roads in the Gorce and Western Tatra Mountains in southern Poland
Authors: Fidelus‐Orzechowska Joanna , Wałdykowski Piotr , Chrobak‐Žuffová Anna , Krzemień Kazimierz , Sosnowska Agnieszka 
Published: January 2025

AbstractThe activity of natural processes in mountain areas is particularly high in zones without permanent vegetation cover. The main aim of the research was to determine the rate of erosion on selected sections of forest roads in the Tatra Mountains and the Gorce Mountains. The research consisted of geomorphological mapping and cyclic comparative measurements within 23 cross‐sections, as well as a comparison of the average annual erosion value obtained based on the WEPP:Road model. The research has shown that the average rate of road erosion in the Tatra Mountains ranged from −4.3 to −1.4 cm year−1. In the Gorce Mountains, the value range was −1.7 to −0.7 cm year−1. The annual erosion for the analysed roads projected by the WEPP:Road model was 29 and 47.4 Mg ha−1 year−1 for roadbeds located in the Western Tatra Mountains while for the Gorce Mountains amounted to 11.4 and 110.5 Mg ha−1 year−1. The projected erosion values increased by an average of 55% when including the width of the road cut slopes. The research has shown that there is a significant difference between the studied forest roads in the Gorce and the Tatra Mountains and that the intensity of road use has the greatest impact on the amount of erosion.
RetroFun‐RVS: A Retrospective Family‐Based Framework for Rare Variant Analysis Incorporating Functional Annotations
Authors: Mangnier Loïc , Ruczinski Ingo , Ricard Jasmin , Moreau Claudia , Girard Simon , Maziade Michel , Bureau Alexandre 
Published: January 2025

ABSTRACTA large proportion of genetic variations involved in complex diseases are rare and located within noncoding regions, making the interpretation of underlying biological mechanisms a daunting task. Although technical and methodological progress has been made to annotate the genome, current disease‐rare‐variant association tests incorporating such annotations suffer from two major limitations. First, they are generally restricted to case−control designs of unrelated individuals, which often require tens or hundreds of thousands of individuals to achieve sufficient power. Second, they were not evaluated with region‐based annotations needed to interpret the causal regulatory mechanisms. In this work, we propose RetroFun‐RVS, a new retrospective family‐based score test, incorporating functional annotations. A critical feature of the proposed method is to aggregate genotypes to compare against rare variant‐sharing expectations among affected family members. Through extensive simulations, we have demonstrated that RetroFun‐RVS integrating networks based on 3D genome contacts as functional annotations reach greater power over the region‐wide test, other strategies to include subregions and competing methods. Also, the proposed framework shows robustness to non‐informative annotations, maintaining its power when causal variants are spread across regions. Asymptotic p‐values are susceptible to Type I error inflation when the number of families with rare variants is small, and a bootstrap procedure is recommended in these instances. Application of RetroFun‐RVS is illustrated on whole genome sequence in the Eastern Quebec Schizophrenia and Bipolar Disorder Kindred Study with networks constructed from 3D contacts and epigenetic data on neurons. In summary, the integration of functional annotations corresponding to regions or networks with transcriptional impacts in rare variant tests appears promising to highlight regulatory mechanisms involved in complex diseases.
Digital Platforms Boundary Resource: A Third‐Party Developers Strategy for Digital Start‐Ups and Market Penetration in Nigeria
Authors: Ajah Emmanuel Okoro 
Published: January 2025

ABSTRACTThird‐party application developers are increasingly using platform‐based business models to enter new markets and create economic value. While prior research has mostly examined the design and architecture of digital platforms, less attention has been given to digital platform boundary resources as an entrepreneurship strategy. The boundary resources of a digital platform significantly impact third‐party developers' motivation to engage in digital entrepreneurship. Consequently, scholars need to carefully investigate the affordances of the boundary resources that influence third‐party developers to create complementary applications as products for entrepreneurial endeavors. To address this gap, the researcher formulated two research questions and conducted an inductive case study to explore the perspectives and views of third‐party application developers in technology hubs within Nigeria's digital start‐up ecosystem. Nigeria has a large youth population with a strong digital potential (i.e., tech‐savvy) and is confronted with uncertainties, limited resources, and complexities. Furthermore, the study is grounded in the technological affordance theory, which guides the researcher's interpretation. The study's findings uncovered the digital platform's boundary resource affordances that play a strategic role in influencing third‐party developers' participation in digital entrepreneurship.
Cutting Through Stigma: Suggested Best Practices for a Harm Reduction Approach to Nonsuicidal Self‐Injury
Authors: Lundeen Lindsay A. , Kern Popejoy Erin 
Published: January 2025

ABSTRACTFor many counselors, both topics of nonsuicidal self‐injury (NSSI) and harm reduction practices can feel intimidating and unclear. Yet, depending on the client, discussion of complete and immediate cessation from NSSI can feel impossible and isolating. This article combines harm reduction principles, a concept initially developed for addiction treatment, with select existing recommendations for NSSI treatment to offer a clinician's guide to best practices for harm reduction implementation with clients engaging in NSSI. By meeting clients where they are and offering a supportive space to brainstorm nontraditional treatment options, counselors can maintain the core principles of the American Counseling Association's Code of Ethics and limit the number of individuals who seek help through online sources. Ethical considerations and implications for counseling are included.
Informative Value of Non‐Financial Reports: Analyzing the Impact of Disclosure Format and Auditing
Authors: Hirsch Simon , Heichl Veronika 
Published: January 2025

ABSTRACTSince the Non‐Financial Reporting Directive (NFRD) came into force in 2017, large, listed companies in the European Union (EU) are obliged to disclose non‐financial reports annually. Accordingly, Member States transposed the Directive into national law with country‐specific rules. Thus far, quantifying the informational content has proven to be difficult. Therefore, we applied an innovative text‐mining approach to assess the informative value of non‐financial reports and its influential determinants, the so‐called Sustainable Fingerprint. This method measures how precisely environmental, social, and governance (ESG) topics and time references are disclosed in non‐financial reports. The aim of our paper is to analyze the informative value of non‐financial reports from companies in the main stock indices of France, Germany, Italy, and Sweden after the national NFRD implementation. Our results show that incorporating the non‐financial report in the annual report and the audit committee expertise (ACE) are positively related to the informative value, whereas external assurance has no significant impact.
The Value of Lacrimal Gland Ultrasonography and Shear Wave Elastography in the Evaluation of Primary Sjögren's Syndrome: A Cross‐Sectional Study
Authors: Zhong Wenxing , Zhang Hua , Ran Haitao 
Published: January 2025

ABSTRACTPurposeThis study evaluates the effectiveness of lacrimal gland ultrasonography (LGUS) and shear wave elastography (SWE) in distinguishing primary Sjögren's syndrome (PSS) patients from healthy controls and examines their role in assessing disease activity and prognosis.MethodsA total of 35 PSS patients and 23 age‐ and gender‐matched healthy controls were included. LGUS was used to grade lacrimal gland structure, while SWE assessed gland elasticity. Disease activity and prognosis were evaluated using european league against rheumatism sjögren's syndrome disease activity index (ESSDAI) and serologic markers.ResultsCompared with healthy controls, LGUS, Emean, and shear wave velocity (SWV) were significantly higher in PSS patients. The optimal cut‐off value of LGUS for diagnosis of PSS was 2 (area under the curve [AUC]: 0.832, sensitivity: 80.0%, specificity: 69.6%), the optimal thresholds for diagnosis of PSS using Emean and SWV values are 9.4 kPa (AUC: 0.768, sensitivity: 65.7%, specificity: 82.6%) and 1.7 m/s (AUC: 0.823, sensitivity: 71.4%, specificity: 91.3%), respectively. There are statistical differences in Emean and SWV between subgroups based on european league against rheumatism sjögren's syndrome disease activity index (ESSDAI); there are statistical differences in LGUS, Emean, and SWV between subgroups based on IgG levels and complement titers.ConclusionLGUS and SWE are accurate, noninvasive diagnostic tools for PSS and may serve as indicators of disease activity and prognosis.