bluuebunny/crossref_metadata_2025_split huggingface dataset:
Job (dis-)satisfaction in pay-for-performance health care contexts: a meta-synthesis of qualitative literature
Authors: Briganti Paola , de Gennaro Davide , Buonocore Filomena , Varriale Luisa 
Published: November 2023

PurposeDrawing on the pay-for-performance (P4P) and job satisfaction literatures through an analysis of qualitative studies published on the topic, the purpose of this study is to investigate the effect of a P4P-based system on job satisfaction and dissatisfaction among health care workers.Design/methodology/approachA meta-synthesis of the qualitative literature was conducted to investigate health care workers' opinions, perceptions and behaviors and fully understand what processes generate job satisfaction or dissatisfaction under P4P systems.FindingsThe findings suggest that P4P systems impact the job (dis-)satisfaction of health care workers based on the institutional, organizational, geographic and cultural context of reference. Specifically, job satisfaction – and thus motivation, occupational well-being and work engagement – can occur when the context is supportive, whereas job dissatisfaction – and thus work stress and pressure, burnout and work-life balance issues and distraction – is generated in the case of unsupportive contexts. Moreover, the findings suggest a virtuous/vicious circle whereby job satisfaction leads to positive performance and further fuels job satisfaction, while conversely job dissatisfaction generates worse performance, and this further worsens worker satisfaction.Originality/valueThere is a lack of studies comparing and analyzing current evidence on the job (dis-)satisfaction of health care workers operating in different contexts based on the reward system. This is the first research to analyze a significant number of studies with reference to the relation between P4P and job (dis-)satisfaction, which are topics in need of further study and investigation in health care settings around the world.
New approaches to dealing with performance management: getting rid of performance appraisals is not the answer
Authors: Murphy Kevin , DeNisi Angelo 
Published: November 2023

PurposeThis paper aims to review the challenges of performance appraisal in organizations and argue that these challenges can and must be overcome.Design/methodology/approachThe authors review research on performance appraisal in organizations and on claims that organizations are abandoning performance appraisal.FindingsStructured performance appraisals are still the norm in organizations around the world. There are clear and practical strategies for improving appraisals. These include improving feedback and removing unnecessary complexity, clarifying the goals of appraisal systems, focusing appraisal on behaviors and outcomes under the employee's control and increasing the fairness of appraisal systems.Research limitations/implicationsResearch is needed on the effects of changing the ways performance appraisals are conducted in organizations.Practical implicationsPractical strategies for improving performance appraisal are outlined.Social implicationsBetter performance appraisals will benefit organizations and their members.Originality/valueThis paper refutes the growing claim that organizations are abandoning performance appraisal and illustrates practical strategies for improving performance appraisal.
For the organization is for oneself: impact of platform leadership on harmonious innovation passion of new-generation employees
Authors: Ding Tianwei , Qi Ziru , Yang Jiaoping 
Published: November 2023

PurposeIn today's digitalized world, platform leadership is a novel leadership style that facilitates employee innovation. However, the impact mechanism of platform leadership on employee innovation passion has not been explored.Design/methodology/approachIn this study, based on the theory of a self-organizing objective system, 591 new-generation employees were surveyed to explore the impact of platform leadership on the harmonious innovation passion of new-generation employees.FindingsThe results showed that platform leadership stimulates the harmonious innovation passion of employees by promoting the integration of organizational and employee objectives. This mechanism was found to be weakened by the internal integrated organizational culture and strengthened by the external adaptive organizational culture.Originality/valueThis study explores the mechanism by which platform leadership style influences the harmonious innovation passion of new-generation employees and provides theoretical guidance and practical insight into ways to improve the innovation capability of new-generation employees.
Language and drawing development after a combined intervention: A single‐subject case study
Authors: Servi Ceyhun 
Published: November 2023

AbstractLanguage and drawing each have their own sets of symbols that they use to convey messages. It is still unclear whether the development of these two expression mechanisms is similar or distinct. There are various approaches to supporting language and communication skills, including structured and naturalistic methods. The goal of this in‐depth case study is to find out how a combined intervention affects the language and drawing abilities of a three‐year‐old girl with developmental delay. Structured implementations and milieu teaching strategies were used in the same session, but not simultaneously. The participant's language and communication skills improved at the end of the programme. Interestingly, even though there was no drawing‐related goal, her drawings evolved too. Even though this is a single‐subject case study, it suggests that if a child's cognitive and language skills develop, his/her drawing skills do as well.
A classification of combined homicide–suicide: An update—Part II: Intrafamilial homicide–suicide
Authors: Felthous Alan R. , Angly Mary , Kahlon Chanchal , Safari Delavar , Masood Yasir , Rodgers Emily , Chennu Navreet 
Published: November 2023

AbstractThis Part II of the three‐part presentation of the updated classification of combined‐homicide published in the Journal of Forensic Sciences addresses intrafamilial homicide–suicides (H–Ss). Intrafamilial H–Ss in this classification includes all close relationships including dating and intimate partners, not just traditional family relationships, in contrast to extrafamilial H–Ss where the victim(s) of homicide are either strangers or in a more formal but nonintimate relationship with the actor. Intrafamilial H–Ss are further divided and classified as intimate partner, filicide, familicide, parricide, and siblicide H–Ss, respectively, and are typically so grouped in the literature.
A classification of combined homicide‐suicide: An update—Part I: Introduction and psychopathology
Authors: Felthous Alan R. , Masood Yasir , Kahlon Chanchal , Safari Delavar , Rodgers Emily , Chennu Navreet , Angly Mary 
Published: November 2023

AbstractA 1995 classification of combined homicide‐suicide was based on the psychopathology of the perpetrator and the relationship between the perpetrator and the victim(s). A three‐part model was proposed for the study and potential understanding of individual homicide‐suicide acts. This triarchic model consisted of the concepts of ego weakness, stress, and vector, the vector representing the ideational component. Today, approaching a quarter of a century after this initial classification based on a review of the literature available then, a considerable volume of experience and investigative knowledge has been published advancing our knowledge of homicide‐suicide. The present review updates and revises the original classification, retains the two‐part, psychopathological and relational classification, and adds several categories. Because this updated classification is more expansive than the original, it is presented in three parts. Part I, the present article, provides the introduction to this classification and the classification of mental conditions that may attend homicide‐suicide. Parts II and III will address intrafamilial and extrafamilial homicide‐suicide, respectively, the two major divisions of the classification based on the relationship between the actor and the homicide victim(s). All three parts are integral to this classification and belong together.
Efficient DIPA‐CRISPR‐mediated knockout of an eye pigment gene in the white‐backed planthopper, Sogatella furcifera
Authors: Zhang Meng‐Qi , Gong Lang‐Lang , Zhao Ya‐Qin , Ma Yun‐Feng , Long Gui‐Jun , Guo Huan , Liu Xuan‐Zheng , Hull J. Joe , Dewer Youssef , Yang Chao , Zhang Ning‐Ning , He Ming , He Peng 
Published: November 2023

AbstractAlthough CRISPR/Cas9 has been widely used in insect gene editing, the need for the microinjection of preblastoderm embryos can preclude the technique being used in insect species with eggs that are small, have hard shells, and/or are difficult to collect and maintain outside of their normal environment. Such is the case with Sogatella furcifera, the white‐backed planthopper (WBPH), a significant pest of Oryza sativa (rice) that oviposits inside rice stems. Egg extraction from the stem runs the risk of mechanical damage and hatching is heavily influenced by the micro‐environment of the rice stem. To bypass these issues, we targeted embryos prior to oviposition via direct parental (DIPA)‐CRISPR, in which Cas9 and single‐guide RNAs (sgRNAs) for the WBPH eye pigment gene tryptophan 2,3‐dioxygenase were injected into the hemocoel of adult females. Females at varying numbers of days posteclosion were evaluated to determine at what stage their oocyte might be most capable of taking up the gene‐editing components. An evaluation of the offspring indicated that the highest G0 gene‐edited efficacy (56.7%) occurred in females injected 2 d posteclosion, and that those mutations were heritably transmitted to the G1 generation. This study demonstrates the potential utility of DIPA‐CRISPR for future gene‐editing studies in non‐model insect species and can facilitate the development of novel pest management applications.
Autonomy: A study of social exchange in a carceral setting
Authors: Walker Michael L. 
Published: November 2023

AbstractMarshaling ethnographic data from a county jail, this study introduces “autonomy”—a novel concept and measurement of the degree to which an actor's exchange initiations are regulated by other exchange relations. This study rearticulates mutual dependence arguments about the social order of penological living in terms of social exchange theory and offers several innovations: 1) the structural forms of exchange relations in a penal housing unit stratify “carceral autonomy” across members of a social order; 2) diminished carceral autonomy contributes to the buildup of “exchange frustration”—the mixture of discontent and sadness experienced when goals cannot be achieved due the structure of an exchange network; 3) deprivations, inefficacies, and imported cultural standards contribute to what is exchanged and with whom in a penological setting; 4) caretaking in penological housing units is as much about maintaining social order through a form of generalized exchange as it is about network members helping each other; and 5) the emotional landscape of penological living can be mapped, in part, by examining the distribution of carceral autonomy and exchange frustration.
PoolParty2: An integrated pipeline for analysing pooled or indexed low‐coverage whole‐genome sequencing data to discover the genetic basis of diversity
Authors: Willis Stuart , Micheletti Steven , Andrews Kimberly R. , Narum Shawn 
Published: November 2023

AbstractWhole‐genome sequencing data allow survey of variation from across the genome, reducing the constraint of balancing genome sub‐sampling with estimating recombination rates and linkage between sampled markers and target loci. As sequencing costs decrease, low‐coverage whole‐genome sequencing of pooled or indexed‐individual samples is commonly utilized to identify loci associated with phenotypes or environmental axes in non‐model organisms. There are, however, relatively few publicly available bioinformatic pipelines designed explicitly to analyse these types of data, and fewer still that process the raw sequencing data, provide useful metrics of quality control and then execute analyses. Here, we present an updated version of a bioinformatics pipeline called PoolParty2 that can effectively handle either pooled or indexed DNA samples and includes new features to improve computational efficiency. Using simulated data, we demonstrate the ability of our pipeline to recover segregating variants, estimate their allele frequencies accurately, and identify genomic regions harbouring loci under selection. Based on the simulated data set, we benchmark the efficacy of our pipeline with another bioinformatic suite, angsd, and illustrate the compatibility and complementarity of these suites using angsd to generate genotype likelihoods as input for identifying linkage outlier regions using alignment files and variants provided by PoolParty2. Finally, we apply our updated pipeline to an empirical dataset of low‐coverage whole genomic data from population samples of Columbia River steelhead trout (Oncorhynchus mykiss), results from which demonstrate the genomic impacts of decades of artificial selection in a prominent hatchery stock. Thus, we not only demonstrate the utility of PoolParty2 for genomic studies that combine sequencing data from multiple individuals, but also illustrate how it compliments other bioinformatics resources such as angsd.
Decreased CD56+CD16‐CD94+uNK cells in the mid‐luteal phase in women with recurrent implantation failure are associated with IL‐15 deficiency
Authors: Zhang Xin‐Xian , Wu Xiao‐Hua 
Published: November 2023

AbstractProblemWhether the abnormal development of uterine natural killer (uNK) cells contributes to women with recurrent implantation failure (RIF) remains unclear.Method of studyWe characterized the development of uNK cells and peripheral blood NK cells (pbNK) in the mid‐luteal phase in women with RIF (n = 31) and controls (n = 14) by flow cytometry. Endometrial IL‐15 mRNA expression was studied by quantitative reverse transcription‐PCR. The GSE58144 dataset was used to validate the correlation results.ResultsWe found decreased proportions of stage 4 CD56+CD16‐CD94+ uNK cells (median: 9.56% vs. 17.78%, P .014) and increased proportions of stage 6 CD56+CD16+CD57+ uNK cells (median: 1.54% vs. 0.74%, P = .020) in the mid‐luteal endometrium of women with RIF compared to fertile women. We also found that there was no quantitative correlation between uNK cells and the corresponding pbNK cell subpopulations (P > .05). In addition, IL‐15 mRNA levels in the mid‐luteal endometrium were positively correlated with the proportion of CD56+ uNK cells (r = .392, P = .008), especially with stage 4 uNK cell populations (r = .408, P = .005).ConclusionsWe showed that the proportion of stage 4 uNK cells decreased in the RIF group compared to controls, and the decrease in stage 4 uNK cells correlated positively with low IL‐15 mRNA expression. We suggest that the reduced stage 4 uNK cells in women with RIF are associated with IL‐15 deficiency.
On the empirical validity of “Gendered reactions to terrorist attacks can cause slumps not bumps” (Holman et al. 2022)
Authors: Jetter Michael , Stockley Kieran 
Published: November 2023

AbstractM. R. Holman, J. L. Merolla and A. Zechmeister (2022) propose women (compared to men) political leaders experience significant drops in public approval ratings after a transnational terrorist attack. After documenting how survey‐based evaluations of then‐Prime Minister Theresa May suffered after the 2017 Manchester Arena attack, Holman et al. (2022) assemble a country–quarter level panel database to explore the generality of their hypothesis. They report evidence suggesting women (compared to men) leaders systematically experience decreased public approval rates after major transnational terrorist attacks (‐value of 0.020). We find that result disappears once any of the following adjustments is implemented: (i) excluding election quarter covariates (), (ii) correcting objective coding errors in the election quarter covariates (), (iii) excluding the May–Manchester observation () or (iv) clustering standard errors at the country level (). Exploring all combinations of the five control groups Holman et al. (2022) incorporate in their specification, none of them clears the 5% threshold of statistical significance once the corrected election quarter variables are employed. We conclude that the empirical evidence does not provide sufficient support for Holman et al.'s (2022) abstract claim that “conventional theory on rally events requires revision: women leaders cannot count on rallies following major terrorist attacks.”
ZFP541 and KCTD19 regulate chromatin organization and transcription programs for male meiotic progression
Authors: Zhou Xu , Fang Kailun , Liu Yanlei , Li Weidong , Tan Yingjin , Zhang Jiaming , Yu Xiaoxia , Wang Guoqiang , Zhang Yanan , Shang Yongliang , Zhang Liangran , Chen Charlie Degui , Wang Shunxin 
Published: November 2023

AbstractThe successful progression of meiosis prophase I requires integrating information from the structural and molecular levels. In this study, we show that ZFP541 and KCTD19 work in the same genetic pathway to regulate the progression of male meiosis and thus fertility. The Zfp541 and/or Kctd19 knockout male mice show various structural and recombination defects including detached chromosome ends, aberrant localization of chromosome axis components and recombination proteins, and globally altered histone modifications. Further analyses on RNA‐seq, ChIP‐seq, and ATAC‐seq data provide molecular evidence for the above defects and reveal that ZFP541/KCTD19 activates the expression of many genes by repressing several major transcription repressors. More importantly, we reveal an unexpected role of ZFP541/KCTD19 in directly modulating chromatin organization. These results suggest that ZFP541/KCTD19 simultaneously regulates the transcription cascade and chromatin organization to ensure the coordinated progression of multiple events at chromosome structural and biochemical levels during meiosis prophase I.
Protocol of the IntenSify‐Trial: An open‐label phase I trial of the CYP3A inhibitor cobicistat and the cytostatics gemcitabine and nab‐paclitaxel in patients with advanced stage or metastatic pancreatic ductal adenocarcinoma to evaluate the combination's pharmacokinetics, safety, and efficacy
Authors: Hohmann Nicolas , Sprick Martin Ronald , Pohl Moritz , Ahmed Azaz , Burhenne Jürgen , Kirchner Marietta , Le Cornet Lucian , Kratzmann Markus , Hajda Jacek , Stenzinger Albrecht , Steindorf Karen , Delorme Stefan , Schlemmer Heinz‐Peter , Riethdorf Sabine , van Schaik Ron , Pantel Klaus , Siveke Jens , Seufferlein Thomas , Jäger Dirk , Haefeli Walter E. , Trumpp Andreas , Springfeld Christoph 
Published: November 2023

AbstractExpression of CYP3A5 protein is a basal and acquired resistance mechanism of pancreatic ductal adenocarcinoma cells conferring protection against the CYP3A and CYP2C8 substrate paclitaxel through metabolic degradation. Inhibition of CYP3A isozymes restores the cells sensitivity to paclitaxel. The combination of gemcitabine and nab‐paclitaxel is an established regimen for the treatment of metastasized or locally advanced inoperable pancreatic cancer. Cobicistat is a CYP3A inhibitor developed for the pharmacoenhancement of protease inhibitors. The addition of cobicistat to gemcitabine and nab‐paclitaxel may increase the antitumor effect. We will conduct a phase I dose escalation trial with a classical 3 + 3 design to investigate the safety, tolerability, and pharmacokinetics (PKs) of gemcitabine, nab‐paclitaxel, and cobicistat. Although the doses of gemcitabine (1000 mg/m2) and cobicistat (150 mg) are fixed, three dose levels of nab‐paclitaxel (75, 100, and 125 mg/m2) will be explored to account for a potential PK drug interaction. After the dose escalation phase, we will set the recommended dose for expansion (RDE) and treat up to nine patients in an expansion part of the trial. The trial is registered under the following identifiers EudraCT‐Nr. 2019‐001439‐29, drks.de: DRKS00029409, and ct.gov: NCT05494866. Overcoming resistance to paclitaxel by CYP3A5 inhibition may lead to an increased efficacy of the gemcitabine and nab‐paclitaxel regimen. Safety, efficacy, PK, and RDE data need to be acquired before investigating this combination in a large‐scale clinical study.
A participatory framework for bridging the conceptual and talent gaps in supply chain management education
Authors: Baveja Alok , Greeley Luke , McLaury William 
Published: November 2023

AbstractThis article argues that current Supply Chain Management (SCM) education and training is inadequate to meet the human capital needs of industry. To bridge this gap, we propose the development and deployment of SCM educational programs that provide learning opportunities earlier in students’ educational journeys. We argue that such programs should be based on self‐directed learning of SCM knowledge, business concepts/skills, and their real‐life application with help from industry partners. We present a case study of a four‐way partnership SCM educational program for high schoolers, which utilizes a project‐based learning method. Survey data and focus group discussion revealed positive developmental learning outcomes, the program's uniqueness, and challenges such as lack of awareness, expertise, and industry partners. We evaluate the efficacy of this four‐way partnership among industry, government agencies, universities, and high schools and discuss the importance of “champions” for each partner. Our findings offer a scalable educational model that leverages multi‐stakeholder engagement to address the SCM talent and educational conceptual gap.
Combination of an extremely rare and a common congenital valvular anomalies: Accessory mitral valve chordae from left atrium and bicuspid aortic valve
Authors: Uygur Begum , Turkmen Irem , Erturk Mehmet 
Published: November 2023

AbstractAccessory chordae tendineae is an extremely rare anomaly. In this case report, we described a 61‐year‐old female patient newly diagnosed with the combination of an accessory mitral valve chordae extending from left atrium which is an extremely rare congenital anomaly and a bicuspid aortic valve. In our patient, three‐dimensional echocardiography showed incremental value over two‐dimensional echocardiography in the assessment of the exact localization and the extend of accessory chordea.
Ocular findings in vitiligo and recommendations for dermatologists
Authors: Poondru Sneha , Alvi Saira , LeWitt Tessa M. , Haddadin Ramez , Kundu Roopal V. 
Published: November 2023

AbstractSince extracutaneous melanocytes in the eye may also be affected in vitiligo, a systematic review was conducted to explore the ocular manifestations of vitiligo. Studies point to a higher risk of ocular findings in periorbital vitiligo. Dry eye disease is the most reported ocular abnormality in vitiligo. Additionally, several small studies have found potential links to uveitis and glaucoma. Various other chorioretinal pigmentary changes are also reported, but without accompanying functional consequences or changes in vision. Although there is a need for larger studies to further elucidate these associations, dermatologists should be aware of potential ocular comorbidities in vitiligo and refer to ophthalmology accordingly.