bluuebunny/crossref_metadata_2025_split huggingface dataset:
Secuencia de movimientos articulares de miembro inferior para evocar el dolor radicular en personas con lumbociática
Authors: Hernández Amaguaya Johannes Alejandro , Castillo Yanez Narcisa Isolina , Erazo Barona Lissette Katherine , Jerez Chiliquinga Héctor Santiago 
Published: February 2024

Introducción. La lumbociática, una afección dolorosa que afecta la región lumbar, es reconocida por la OMS como un problema global de salud. Se clasifica en aguda, subaguda y crónica, impactando en la calidad de vida de los pacientes. La excursión del nervio ciático, vinculada a la neurobiomecánica, influye en la aparición de dolor radicular. Objetivo. Analizar la secuencia de movimientos de las extremidades inferiores para evocar el dolor radicular en personas con lumbociática, considerando la neurobiomecánica y la precisión diagnóstica de las pruebas. Metodología. Se realizó una revisión sistemática sobre la neurobiomecánica del nervio ciático durante movimientos de extremidades inferiores y la precisión diagnóstica en casos de dolor radicular. Resultados. Se examinaron 132 estudios, seleccionando 6 para revisión. Conclusión. El estudio destaca la influencia de la secuencia de movimientos en el dolor radicular, especialmente con dorsiflexión. Pruebas como Slump y otras son útiles para evaluar lesiones lumbosacras y se recomienda explorar movimientos adicionales en futuras investigaciones. Área de estudio general: Fisioterapia. Área de estudio específica: Fisioterapia. Tipo de estudio: Revisión bibliográfica.
Enfoque de los derechos colectivos: análisis diarios Los Andes y La Prensa en 2022
Authors: Lomas Badillo Edison Raúl , Benalcazar Valle Jennifer Johana 
Published: February 2024

Introducción: La convergencia entre los medios escritos y los Derechos Colectivos es esencial en la dinámica informativa, especialmente en el ámbito de los medios impresos, donde la prensa ejerce un poder significativo al moldear opiniones, informar y catalizar acciones en la sociedad. Objetivos: El objetivo de la investigación es: a) Identificar los Derechos Colectivos con mayor con mayor incidencia en los medios. b) Analizar como aporta la prensa en la difusión de noticias sobre los Derechos Colectivos. Metodología: Estudio cualitativo, analiza la cobertura de derechos colectivos en los diarios La Prensa y Los Andes en el periodo 2022. Se revisaron 877 publicaciones en La Prensa y 484 en Los Andes. La muestra aleatoria incluyó 255 notas de La Prensa (enero, mayo, noviembre) y 144 de Los Andes (febrero, julio, septiembre). En total, se examinaron 399 notas periodísticas, con la cobertura de Derechos Colectivos. Resultados: Ambos diarios comparten un fuerte compromiso con la diversidad, la inclusión y la relevancia, evidenciado en sus iniciativas específicas para colectivos y la ausencia de restricciones en la cobertura de noticias. Conclusiones: La Prensa y Los Andes desempeñan un papel fundamental al informar y sensibilizar a la sociedad sobre la importancia de los Derechos Colectivos en la construcción de sociedades equitativas y justas. Área de estudio general: Comunicación. Área de estudio Específico: Derechos Colectivos
A Proposed Model For Predicting Financial Tumble And Financial Economics
Authors: Al Ethari Rawaa Yasir Mahdi 
Published: February 2024

The study aimed to address the concept of financial and banking defaults and to identify performance indicators and their role in predicting financial defaults in the research sample banks. Developing a standard model consisting of a set of financial ratios capable of distinguishing between troubled banks and non-performing banks. And testing the ability of the proposed model to distinguish between troubled and non-performing banks. Logistic regression model was used to test the research data. The statistical method was used logistic regression analysis to interpret the relationship between a set of variables, and then apply the stepwise selection method through which models can be generated and the best model can be selected from the sum of financial indicators that can be applied and distinguish between troubled and non-performing banks, as the classification related to banks being (in troubled, not in troubled) showed that the total non-performing Iraqi banks are (6) and the non-performing banks are (9) out of the total (15) banks within the years of the research. The study concluded that financial stumbling has a great impact on many parties and parties, as financial stumbling affects the banks themselves as well as the owners and creditors, and it can result in large losses that lead the bank to bankruptcy. This is in addition to the pressures faced by the administration, foremost of which is the relinquishment of the position to a new administration.
The Impact of Implementing Merdeka Belajar Curriculum by Utilizing Digital Media on Changes in Knowledge, Attitudes and Skills of Madrasah Ibtidaiyah Al I'anah Students, Duren Village, Klari District, Karawang Regency
Authors: Masruroh Siti , Hoerudin Hoerudin , Priyatna Bayu 
Published: February 2024

Merdeka Belajar Curriculum is a curriculum of a set of plans and arrangements regarding the objectives, content and learning materials of the methods used as guidelines for organizing learning activities to achieve certain educational goals. The central government establishes a basic framework and curriculum structure which serves as a reference for the development of the operational curriculum for education units. According to the National Standards Agency, Merdeka Belajar is education so that students can choose subjects of interest. This is done so that students can optimize their talents. The purpose of this writing, namely to find out the impact of the implementation of the independent learning curriculum on the attitudes, knowledge and skills of Madrasah Ibtidaiyah Al'Ianah students in Duren Village, Klari Distric. Implementation method with observation and field studies.
Toprak Beyi Olarak Adnan Menderes ve Çakırbeyli Çiftliğinde Etkilendiği İsimler
Authors: DURMUŞ Sevilay 
Published: February 2024

Adnan Menderes’in siyasete girmeden önceki hayatı, onun siyasî yaşamının gölgesinde kalmıştır denilebilir. Fakat Menderes’in çiftlik hayatı ve ilk gençlik yılları sonraki yaşamını derinden şekillendiren bir özelliktedir. Çünkü tarihe geçmiş her şahsiyet onu meydana getiren ortamın bir mahsulüdür. Hayata Aydın’da gözlerini açan Menderes küçük yaşta en yakınlarını kaybetmiştir. Onun mizacının oluşmasında ve hayatının ileriki yıllarında anne-babasının ve ablasının ölümünden sonra ailedeki tek hamisi olan babaanne Fatma Fitnat Hanım’ın önemli bir rol oynadığı düşünülebilir.
Daha sonraki dönemlerde Çakırbeyli, köylüler ve çiftlik evi üçgeninde kendisine rehberlik eden adeta onu hayata hazırlayan kâhyalar da oldukça önemlidir. Menderes halkın içinde yetişmiş topraktan gelen bir şahsiyettir. Menderes’i anlamak onun etkilendiği ortamı anlamakla mümkündür. Temas ettiği insanlar, yaşadığı zaman dilimi ve yetiştiği çevre bu ortamı oluşturan unsurlardır. Onu yetiştiren bu ortamın önemi, onun toprakla olan bağı, çiftlik hayatına duyduğu özlem sık sık konuşmalarına da yansımıştır. Bu çalışma ile Adnan Menderes’in siyasete girmeden önceki yaşamında bir toprak beyi olarak şekillenmesinde önemli rol oynayan kişiler ve olaylar ele alınmıştır. Söz konusu bilgiler çoğunlukla birincil kaynak kişilerle yapılan derleme çalışmaları ve yapılandırılmış görüşmelerle elde edilmiştir.
Nurturing Teacher Leadership: A Principal Strategy to Develop Teacher Leader in Madrasah
Authors: Sholihah Hidayatus , Syukur Fatah , Ismail Ismail , Zaenurrosyid Zaenurrosyid , Hussin Zaharah 
Published: February 2024

This research paper aims to interpret the experience of Islamic school (Madrasah) principals in nurturing leadership skills of Islamic Teaching (PAI) teachers to lead outside the classroom in three State Madrasah of Central Java, Indonesia. It was qualitative research with a Phenomenology approach, using in-depth interviews, observation, and documentation. Data was analyzed using the Miles and Huberman Model of analysis by applying three steps: data reduction, data display, and verification. The result shows that the principals of three Madrasah in Central Java have nurtured PAI teachers leaders by distributing the leadership roles, modeling persistently to lead the various programs, applying a democratic style of leadership, building teachers' intrinsic and extrinsic motivation to work, applying learning organization by facilitating teamwork, training and development program. Thus, PAI teacher leaders can be developed well in Madrasah, Central Java. This can lead to improving the Human resources teacher quality at Madrasah so that it can face the challenges in this 21st-century era.
Exploring the anticancer and antibacterial potential of naphthoquinone derivatives: a comprehensive computational investigation
Authors: Meem Mehnaz Hossain , Yusuf Sumaiya Binte , Al Abbad Sanaa S. , Rahman Shofiur , Al-Gawati Mahmoud , Albrithen Hamad , Alodhayb Abdullah N. , Uddin Kabir M. 
Published: February 2024

This study investigates the potential of 2-(4-butylbenzyl)-3-hydroxynaphthalene-1,4-dione (11) and its 12 derivatives as anticancer and biofilm formation inhibitors for methicillin-resistant staphylococcus aureus using in silico methods. The study employed various computational methods, including molecular dynamics simulation molecular docking, density functional theory, and global chemical descriptors, to evaluate the interactions between the compounds and the target proteins. The docking results revealed that compounds 9, 11, 13, and ofloxacin exhibited binding affinities of −7.6, −7.9, −7.5, and −7.8 kcal mol−1, respectively, against peptide methionine sulfoxide reductase msrA/msrB (PDB: 3E0M). Ligand (11) showed better inhibition for methicillin-resistant staphylococcus aureus msrA/msrB enzyme. The complex of the 3E0M-ligand 11 remained highly stable across all tested temperatures (300, 305, 310, and 320 K). Principal Component Analysis (PCA) was employed to evaluate the behavior of the complex at various temperatures (300, 305, 310, and 320 K), demonstrating a total variance of 85%. Convergence was confirmed by the eigenvector’s cosine content value of 0.43, consistently displaying low RMSD values, with the minimum observed at 310 K. Furthermore, ligand 11 emerges as the most promising candidate among the compounds examined, showcasing notable potential when considering a combination of in vitro, in vivo, and now in silico data. While the naphthoquinone derivative (11) remains the primary candidate based on comprehensive in silico studies, further analysis using Frontier molecular orbital (FMO) suggests while the Egap value of compound 11 (2.980 eV) and compound 13 (2.975 eV) is lower than ofloxacin (4.369 eV), indicating their potential, so it can be a statement that compound 13 can also be investigated in further research.
Exploring the potential of a Ephedra alata leaf extract: Phytochemical analysis, antioxidant activity, antibacterial properties, and green synthesis of ZnO nanoparticles for photocatalytic degradation of methylene blue
Authors: Zaater Abdelmalek , Serhoud Mohammed Oualid , Ben Amor Ilham , Zeghoud Soumeia , Hemmami Amira , Rebiai Abdelkrim , Bouras Yacine , Laiche Ammar Touhami , Alsalme Ali , Cornu David , Bechelany Mikhael , Barhoum Ahmed 
Published: February 2024

Ephedra alata leaf extracts have therapeutic properties and contain various natural compounds known as phytochemicals. This study assessed the phytochemical content and antioxidant effects of a Ephedra alata leaf extract, as well as zinc oxide (ZnO) nanoparticle production. The extract contained phenolic acids, including vanillic acid, chlorogenic acid, gallic acid, p-coumaric acid, vanillin and rutin. Its total phenolic content and total flavonoid content were 48.7 ± 0.9 mg.g-1 and 1.7 ± 0.4 mg.g-1, respectively. The extract displayed a DPPH inhibition rate of 70.5%, total antioxidant activity of 49.5 ± 3.4 mg.g-1, and significant antimicrobial activity toward Gram-positive and negative bacteria. The synthesized ZnO nanoparticles had spherical shape, crystallite size of 25 nm, particle size between 5 and 30 nm, and bandgap energy of 3.3 eV. In specific conditions (90 min contact time, pH 7, and 25°C), these nanoparticles efficiently photodegraded 87% of methylene blue, suggesting potential applications for sustainable water treatment and pollution control.
Bone metabolism and inflammatory biomarkers in radiographic and non-radiographic axial spondyloarthritis patients: a comprehensive evaluation
Authors: Gómez-García Ignacio , Ladehesa-Pineda Maria L. , Diaz-Tocados Juan M. , López-Medina Clementina , Abalos-Aguilera Maria C. , Ruiz-Vilches Desiree , Paz-Lopez Guillermo , Gonzalez-Jimenez Andres , Ranea Juan A. G. , Escudero-Contreras Alejandro , Moreno-Indias Isabel , Tinahones Francisco J. , Collantes-Estévez Eduardo , Ruiz-Limón Patricia 
Published: February 2024

IntroductionAxial spondyloarthritis (axSpA) is a heterogeneous disease that can be represented by radiographic axSpA (r-axSpA) and non-radiographic axSpA (nr-axSpA). This study aimed to evaluate the relationship between the markers of inflammation and bone turnover in r-axSpA patients and nr-axSpA patients.MethodsA cross-sectional study included 29 r-axSpA patients, 10 nr-axSpA patients, and 20 controls matched for age and sex. Plasma markers related to bone remodeling such as human procollagen type 1 N-terminal propeptide (P1NP), sclerostin, tartrate-resistant acid phosphatase 5b (TRACP5b), receptor activator of nuclear factor kappa B ligand (RANKL), and osteoprotegerin (OPG) were measured by an ELISA kit. A panel of 92 inflammatory molecules was analyzed by proximity extension assay.ResultsR-axSpA patients had decreased plasma levels of P1NP, a marker of bone formation, compared to controls. In addition, r-axSpA patients exhibited decreased plasma levels of sclerostin, an anti-anabolic bone hormone, which would not explain the co-existence of decreased plasma P1NP concentration; however, sclerostin levels could also be influenced by inflammatory processes. Plasma markers of osteoclast activity were similar in all groups. Regarding inflammation-related molecules, nr-axSpA patients showed increased levels of serum interleukin 13 (IL13) as compared with both r-axSpA patients and controls, which may participate in the prevention of inflammation. On the other hand, r-axSpA patients had higher levels of pro-inflammatory molecules compared to controls (i.e., IL6, Oncostatin M, and TNF receptor superfamily member 9). Correlation analysis showed that sclerostin was inversely associated with IL6 and Oncostatin M among others.ConclusionAltogether, different inflammatory profiles may play a role in the development of the skeletal features in axSpA patients particularly related to decreased bone formation. The relationship between sclerostin and inflammation and the protective actions of IL13 could be of relevance in the axSpA pathology, which is a topic for further investigation.
Research on multi-physical field analysis and assessment technique of virtual connection defects in cluster cable joints based on digital twin technology
Authors: Ma Qiang , Liu Yan , Liu Zitong , Li Wenyu , Li Dongxue , Liu Ran , Jing Yongteng 
Published: February 2024

As the “blood vessels” and “nerves” of the power grid, cables are important carriers for transmitting electric energy, and their failures will affect the safe and stable operation of the power grid. In this paper, a digital twin model of thermal characteristics is constructed for 10 kV YJV×400 cluster cable and its joint model. Based on the multi-physical field coupling analysis method, the fluid field, temperature field and current-carrying capacity of the cluster cable are analyzed. The temperature rise and airflow distribution characteristics of the joint and its external insulation when the defect of joint false connection occurs are analyzed. Based on the fuzzy analytic hierarchy process (FAHP), weights are assigned to the locations of multiple measurement points of the cable external insulation, and the temperature distribution of each measurement point is combined with the digital twin technology to calculate the hot spot temperature of the cable, so as to assess the defects of the joints of the cables. The digital twin platform is used for real-time monitoring of cable status and assessment of defects. The temperature rise experiments of cables under different carrying capacity and joint defects show that this method can accurately and efficiently calculate hot spot temperatures and assess defects of joints in cluster cables.
Distribution, sources and health risk assessment of polycyclic aromatic hydrocarbons in urban soils under different landform conditions of Taiyuan, China
Authors: Liu Liwen , Chen Xiangling , Duan Yonghong , Wu Zhangwei , Xu Lishuai 
Published: February 2024

Public concern about polycyclic aromatic hydrocarbons (PAHs) is rising due to their potential carcinogenic, teratogenic, and mutagenic effects. This study assessed PAHs in Taiyuan City’s plain and mountain soil, investigating concentrations, distribution, sources, and carcinogenic risk. Σ21PAHs concentrations in plain topsoil ranged from 133.2 to 6,410.6 ng/g (mean 1,444.7 ng/g), and in mountain soil from 66.5 to 2,250.2 ng/g (mean 585.5 ng/g). Approximately 55.1% of plain and 19.0% of mountain soil samples had contamination levels exceeding 600 ng/g. In plain soil, 4-ring and 5-ring PAHs dominated, while 2-ring and 3-ring PAHs were prevalent in mountain soil. Polluted areas in Taiyuan were primarily centered in the central-north, with higher content closer to industrial or business districts. PAH isomer ratios and principal component analysis/multiple linear regression (PCA/MLR) indicated coal combustion as the main PAH source, followed by coke production, vehicle emissions, and biomass combustion. Incremental lifetime cancer risks (ILCRs) showed Taiyuan’s PAH-related cancer risks were generally low, though heavily contaminated areas exhibited moderate risks. Plain regions had three times higher cancer risk than mountains, with children facing higher risk than adults. These findings highlight the need to consider PAH pollution while enhancing urban environmental quality.
Effects of drought-induced stress on nematode communities in aquatic and terrestrial habitats of the Nebraska Sandhills
Authors: Gattoni Kaitlin , Gendron Eli M. S. , Powers Kirsten , Powers Thomas O. , Harner Mary J. , Porazinska Dorota L. 
Published: February 2024

IntroductionGlobal change events (e.g., worsening drought) are increasing environmental stress in a variety of terrestrial and aquatic habitats. The degree to which communities in soils and sediments are driven by temporal environmental changes across multiple habitat types from the same region is not clear.MethodsWe used nematodes, a common bioindicator of soil and sediment health, to determine how community diversity and composition are altered by rising alkalinity across lakes, shorelines, and prairies in the western Nebraska Sandhills. We sampled these three habitats from five lake basins spanning an alkalinity gradient (pH 7–11) across three years (2019, 2020, 2021). During our sampling, the Sandhills experienced a range of drought intensities, with 2019 being a wet year, followed by severe drought in 2020, and abnormally dry/moderate drought in 2021. To determine if diversity and composition of nematodes responded to increased alkalinity and drought-induced stress we used different modelling approaches, including Random Forest and pairwise comparisons.Results and discussionOverall, nematode diversity in lakes was most affected by increasing alkalinity over time, whereas in shorelines and prairies diversity was most reliant on bacterial diversity and potential nematode-nematode interactions. In comparison to shorelines and prairies, community composition in lakes was the least variable and consistently driven by pH and lake water levels. In contrast, compositions in the shorelines and prairies were more variable and explained at varying degrees by pH, year, lake basin, and climate-associated variables. In addition, relative abundance and compositional nature of select copious taxa were highly unpredictable, indicating potential instability in these habitats. Future research is necessary to address the ecologic stability of the Sandhills and determine where conservation efforts are most needed.
Targeting Wnt signaling for improved glioma immunotherapy
Authors: Gutova Margarita , Hibbard Jonathan C. , Ma Eric , Natri Heini M. , Adhikarla Vikram , Chimge Nyam-Osor , Qiu Runxiang , Nguyen Cu , Melendez Elizabeth , Aguilar Brenda , Starr Renate , Yin Holly , Rockne Russel C. , Ono Masaya , Banovich Nicholas E. , Yuan Yate-Ching , Brown Christine E. , Kahn Michael 
Published: February 2024

IntroductionDespite aggressive standard-of-care therapy, including surgery, radiation, and chemotherapy, glioblastoma recurrence is almost inevitable and uniformly lethal. Activation of glioma-intrinsic Wnt/β-catenin signaling is associated with a poor prognosis and the proliferation of glioma stem-like cells, leading to malignant transformation and tumor progression. Impressive results in a subset of cancers have been obtained using immunotherapies including anti-CTLA4, anti-PD-1, and anti-PD-L1 or chimeric antigen receptor (CAR) T cell therapies. However, the heterogeneity of tumors, low mutational burden, single antigen targeting, and associated antigen escape contribute to non-responsiveness and potential tumor recurrence despite these therapeutic efforts. In the current study, we determined the effects of the small molecule, highly specific Wnt/CBP (CREB Binding Protein)/β-catenin antagonist ICG-001, on glioma tumor cells and the tumor microenvironment (TME)–including its effect on immune cell infiltration, blood vessel decompression, and metabolic changes.MethodsUsing multiple glioma patient-derived xenografts cell lines and murine tumors (GL261, K-Luc), we demonstrated in vitro cytostatic effects and a switch from proliferation to differentiation after treatment with ICG-001.ResultsIn these glioma cell lines, we further demonstrated that ICG-001 downregulated the CBP/β-catenin target gene Survivin/BIRC5–a hallmark of Wnt/CBP/β-catenin inhibition. We found that in a syngeneic mouse model of glioma (K-luc), ICG-001 treatment enhanced tumor infiltration by CD3+ and CD8+ cells with increased expression of the vascular endothelial marker CD31 (PECAM-1). We also observed differential gene expression and induced immune cell infiltration in tumors pretreated with ICG-001 and then treated with CAR T cells as compared with single treatment groups or when ICG-001 treatment was administered after CAR T cell therapy.DiscussionWe conclude that specific Wnt/CBP/β-catenin antagonism results in pleotropic changes in the glioma TME, including glioma stem cell differentiation, modulation of the stroma, and immune cell activation and recruitment, thereby suggesting a possible role for enhancing immunotherapy in glioma patients.