bluuebunny/crossref_metadata_2025_split huggingface dataset:
Ortodoncia lingual como paradigma de los tratamientos invisibles contemporáneos. Una revisión sistemática
Authors: Benavides Machuca María Augusta , Zapata Hidalgo Christian David 
Published: December 2023

Introducción. El concepto de aparatología estética en ortodoncia ha experimentado una constante renovación, los tratamientos invisibles son cada vez más atractivos para los pacientes. Esta tendencia se ha visto opacada por la dificultad del manejo de la técnica y la curva de aprendizaje laboriosa. La siguiente revisión tiene como objetivo brindar al lector toda la información actual sobre ortodoncia lingual mediante la recopilación de literatura desde su éxito a la decadencia y resurgimiento, así como su impacto hacia el futuro con la finalidad de que las referencias aquí presentadas permitan al sistema lingual ser el sello distintivo de un especialista en la ortodoncia moderna. Metodología: La revisión sistemática encargada de recopilar información sobre Ortodoncia Lingual se realizó mediante la búsqueda electrónica extensiva en diversas bases de datos digitales como Pubmed, Web of Science, ProQuest, Cochrane, Epistemonikos, Springer, Ovid, Google Academic, Scopus, Taylor & Francis. La búsqueda de la información se realizó desde el año 1982 al 2022 en idioma español, inglés, francés y portugués. Resultados: Para esta revisión se estableció un registro de base de datos siendo un total de N= 3.684 estudios. Se realizó un primer cribado dejando 2.549 artículos; luego de esta selección, se eliminó la bibliografía duplicada, quedando 2.062 artículos. Después de verificar todos los registros, se excluyeron 2.036 estudios que no cumplieron con los criterios de selección, lo que resultó en 26 artículos adecuados para esta revisión sistemática. Conclusión: La literatura disponible reveló que las dificultades técnicas como el manejo de la aparatología, las limitaciones biomecánicas y la falta de formación por parte de los profesionales han influido en la escasa utilización de esta técnica. Área de estudio general: Odontología. Área de estudio específica: Ortodoncia. Tipo de estudio: Artículo original.
Pengaruh Variasi Jenis Serbuk Kayu Terhadap Pertumbuhan (Auricularia Auricula) Sebagai Pengembangan Booklet
Authors: Safiera Cut Kandy , Kasrina Kasrina , Yennita Yennita , Irawati Sri , Jumiarni Dewi , Ansori Irwandi , Hidayat Syarif 
Published: December 2023

Penelitian ini bertujuan untuk mengetahui pengaruh variasi jenis serbuk kayu pada proses budidaya jamur kuping dan mendeskripsikan hasil uji kelayakan Booklet yang dirancang berdasarkan proses budidaya jamur kuping dan pengaruh variasi serbuk kayu sebagai media tanam yang digunakan di Rumah Jamur SMK Agribisnis Dangau Datuk Bengkulu. Jenis penelitian ini merupakan penelitian dan pengembangan (Research and Development) model Borg and Gall 1989 (dalam Sugiyono 2016) yang terdiri dari 10 tahap, akan tetapi pada penelitian ini hingga 5 tahapan yaitu 1) Potensi dan masalah, 2) Pengumpulan data, 3) Desain produk, 4) Validasi desain, dan 5) revisi desain. Variasi serbuk kayu yang digunakan dalam penelitian ini adalah serbuk gergaji kayu Durian 100% (P1), serbuk gergaji Kayu Bawang 100% (P2), serbuk gergaji kayu Sengon 100% (P3), dan serbuk gergaji kayu Durian 50% ditambah serbuk gergaji Kayu Bawang 20% dan serbuk gergaji kayu Sengon 30%. (P4). Hasil yang diperoleh diketahui bahwa serbuk kayu yang paling baik digunakan untuk budidaya jamur kuping yaitu serbuk kayu sengon dengan pertumbuhan miselium memenuhi baglog selama 41 hari dan munculnya primordia rata-rata selama 42 hari. Booklet budidaya jamur kuping yang telah disusun pada penelitian ini dinyatakan sangat layak oleh validator dengan rerata presentase validasi sebesar 89,17%.Kata Kunci: Booklet, Jamur Kuping, Serbuk Kayu
Video Animasi Materi Sistem Reproduksi Menjadi Solusi Mengatasi Rendahnya Minat Peserta Didik
Authors: Amatullah Tara Fadhila , Wicaksana Ervan Johan , Hamidah Afreni 
Published: December 2023

Salah satu aspek dalam pendidikan yang mengikuti perkembangan teknologi adalah media pembelajaran yang digunakan guru untuk menyampaikan materi kepada peserta didik. Penggunaan media yang kurang bervariasi dalam pembelajaran berdampak pada kurangnya minat dan perhatian peserta didik. Oleh karena itu penelitian ini bertujuan untuk mengembangkan media pembelajaran video animasi menggunakan animaker serta untuk melihat kelayakan media pembelajaran yang akan divalidasi oleh ahli media dan materi. Media pembelajaran yang dikembangkan mencakup materi sistem reproduksi. Penelitian ini dilaksanakan di Madrasah Aliyah Laboratorium Kota Jambi. Jenis penelitian yang dilakukan adalah penelitian pengembangan (R&D) dengan tahapan pengembangan terdiri atas Analyze, Design, Development, and Evaluation. Uji coba dilakukan kepada 6 orang peserta didik (kelompok kecil) dan 30 orang peserta didik (kelompok besar). Hasil validasi ahli media adalah 92%, ahli materi adalah 94% dengan kategori “Sangat Layak”. Hasil uji coba kelompok kecil adalah 89%, kelompok besar dengan persentase 87%, termasuk dalam kategori “Sangat Baik”. Dengan demikian dapat disimpulkan bahwa pengembangan media pembelajaran video animasi menggunakan animaker pada materi sistem reproduksi di SMA/MA yang dilakukan layak digunakan dalam proses pembelajaran serta dapat mengatasi permasalahan perhatian dan minat peserta didik.
Niebezpieczne związki. Problem bliskości we współczesnej dyskusji nad zasadą podwójnego skutku
Authors: Chyrowicz Barbara 
Published: December 2023

„Problem bliskości” (closeness problem) został postawiony przez Philippę Foot w artykule The Problem of Abortion and the Doctrine of Double Effect. Autorka poddaje w nim krytyce klasyczną wersję zasady podwójnego skutku odróżniającą zamierzenie bezpośrednie od pośredniego i uznającą na tej podstawie za usprawiedliwione powodowanie złych skutków, które były wprawdzie przez sprawcę przewidywane, ale nie zamierzone. Foot uważa, że jeśli uznajemy spowodowanie złego skutku za usprawiedliwione, to sposób w jaki tego dokonujemy nie ma znaczenia, odwołanie do dystynkcji pośrednio/bezpośrednio może natomiast prowadzić w niektórych przypadkach do absurdalnych rozwiązań pozwalających wyróżnić w jednym działaniu dwa zdarzenia – stanowiące odpowiednio przedmiot pośredniego i bezpośredniego zamierzenia – które są względem siebie zbyt bliskie, by można do nich zastosować zasadę podwójnego skutku, np. wtedy, kiedy lekarz przeprowadza operację kraniotomii. Istotą tak zdefiniowanego problemu bliskości jest pytanie o możliwe kryterium, które pozwoliłoby określić, które ze skutków działania mieszczą się w zamierzeniu, a które są jedynie przewidywane. Punktem wyjścia prowadzonych w artykule analiz problemu bliskości będzie sposób, w jaki postawiła go w swoim artykule Foot. W drugiej, najobszerniejszej części artykułu zostanie przytoczonych szereg współczesnych prób rozstrzygnięcia problemu bliskości, trzecia natomiast jest próbą odpowiedzi na pytanie, dlaczego dyskusja nad problemem bliskości zdaje się tkwić w martwym punkcie.
Clinical case of endometrial stromal sarcoma
Authors: Yashin S. S. , Luneva E. V. , Goroshkina A. A. , Shatunova E. P. , Neganova O. V. , Yashina O. V. 
Published: December 2023

Relevance. Endometrial stromal sarcomas are rare tumors that account for about 0.2% of all malignant tumors of the genital tract. It is believed that they are more common in premenopausal women. Endometrial stromal sarcomas are hormone-sensitive tumors. Because of the rarity of this tumor, there are a limited number of reports in the publications concerning the clinical control and the final result of such cases.Purpose. To study the main pathogenetic, clinical and morphological features of endometrial stromal sarcoma on the example of a clinical case.Materials and methods. The article presents a clinical case of malignant tumor of the uterus, histologically – endometrial stromal sarcoma.Results and conclusions. Diagnosis of endometrial stromal sarcoma is difficult; tumor verification requires mandatory histological examination. Difficulties in diagnosis largely determine the low early detection and poor prognosis in patients with endometrial sarcomas.
Pembuatan Aplikasi E-Learning sebagai Media Pembelajaran Online pada Politeknik Kediri
Authors: Ajeng Yuli  , Andika Kurnia Adi Pradana  , Nur Laila Ulfah  
Published: December 2023

e-Learning adalah aplikasi untuk saling berbagi ilmu pengetahuan diantara mahasiswa dan dosen jurusan, atau merupakan suatu sistem belajar jarak jauh dengan berbasis teknologi informasi. E-learning telah menujadi suatu kebutuhan bagi civitas akademika, mengingat baik dosen, mahasiswa maupun institusi Pendidikan telah memanfaatkan teknologi komputer dalaml proses belajar mengajar. Politeknik Kediri sebagai civitas akademika, memiliki peluang dan kemampuan untuk mengimplementasikan e-learning sebagai sarana peningkatan kualitas Pendidikan terutama dalam proses belajar mengajar, karena proses belajar mengajar di Politeknik Kediri cenderung dilakukan di kampus pada jam perluliahan.
Aplikasi e-learning untuk Politeknik Kediri memiliki bebnerapa menu seperti menu artikel, menu info dan menu yang dapat dipergunakan oleh mahasiswa dan dosen dalam menambah atau melihat materi, melihat mahasiswa, melihat dan memberi nilai mahasiswa, mengikuti mata kuliah dan melakukan tanya jawab dengan seluruh mahasiswa maupun dosen Politeknik Kediri.
Dengan adanya aplikasi ini, mahasiswa dan dosen dapat melakukan kegiatan belajar mengajar maupun saling berbagi ilmu pengetahuan di luar jam perkuliahanm tanpa terbatas jarak dan waktu. Sehingga kegiatan belajar mengajar di Politeknik Kediri menjadi mudan, lebih efektif dan efisien.
Pembelajaran Tulang Manusia Berbasis Multimedia
Authors: Hendro Harmono  , Fery Sofian Efendi  
Published: December 2023

Perkembangan teknologi informasi telah mengubah manusia dalam menyelesaikan semua pekerjaannya, tidak hanya dalam pekerjaannya saja tetapi dalam segala aspek kehidupan manusia, seperti pada lembaga Pendidikan, komputer dapat menjadi media pembelajaran yang baru. Pembelajaran yang didapat di sekolah terkadang membuat siswa merasa bosan. Hal itu disebabkan penyampaian materi yang kuran gmenarik. Oleh sebab itu, di setiap sekolah diperlulkan media pembelajaran yang dimana setiap siswa bisa bersemangat dan mempunyai minat untuk mengikuti kegiatan belajar mengajar.
Menggunakan pembelajaran berbasis multimedia, materi pembelajaran yang awalnya hanya menggunakan buku bacaan bisa dirubah menjadi tampilan yang lebih menarik yaitu dengan mengubahnya menjadi gambar gerak atau animasi.
PopStress: designing organizational stress intervention for office workers
Authors: Bao Yanchi , Xue Mengru , Gohumpu Jennifer , Cao Yumeng , Hu Jun 
Published: December 2023

IntroductionExcessive work stress on office workers will affect people's health and work efficiency, and organizational stress management is becoming more and more critical. Current studies focus on the management of individual stress. The collective nature of stress and coping needs further exploration.MethodsThis paper proposes the PopStress system, which converts the negative stress of an office group into the energy of a popcorn machine. When the organizational stress accumulates to the threshold, the popcorn machine will start making popcorn and attract office workers to take a break and eat. Through multisensory stimuli such as visual, audio, and olfaction, the system encourages natural and entertaining social stress-relieving behaviors within the office.ResultsTwenty-four office workers were recruited and divided into six groups for the user study. The results showed that PopStress enables users to understand the collective stress status, and successfully relieved the individual's physiological and psychological stress. This work provides insights into organizational stress management, health product design, and social design.
Advancing paediatric cardiac imaging: a comprehensive analysis of the feasibility and accuracy of a novel 3D paediatric transoesophageal probe
Authors: Karsenty Clément , Hadeed Khaled , Pyra Pierrick , Guitarte Aitor , Djeddai Camelia , Vincent Remi , Dulac Yves , Silagdze Ia , Gobin Julie , Combes Nicolas , Ratsimandresy Miarisoa , Berthomieu Lionel , Calvaruso Davide , Acar Philippe 
Published: December 2023

AimsPediatric transoesophageal echocardiography (TOE) probes have remained two-dimensional (2D) limiting their use compared to adults. While critical in pediatrics for interventions and post-surgery assessments, technological advancements introduced a three-dimensional (3D) pediatric TOE probe. This study assessed the new 3D pediatric TOE probe (GE 9VT-D) for feasibility, handling, and imaging quality.Methods and resultsAt Children's Hospital of Toulouse, 2-month prospective study enrolled children undergoing TOE with the new probe. All imaging modalities were rated by 2 operators using a 5-point Likert-type scale from 1 (very poor) to 5 (very good) quality. Forty-five children, median age 3.7 (range: 2 months-14.7 years) median weight 7.8 kg (range: 4.3–48 kg) underwent 60 TOEs: 25% pre-surgery, 45% post-surgery, 28% during percutaneous procedures, and 2% in intensive care. Probe handling was “very easy” in all cases without adverse events. The median score of 2D, 2D colour, pulsed Doppler and 3D were noted 5 out of 5 and continuous Doppler and 3D colour 4 out of 5. The 3D image quality remained consistent irrespective of the patient weighing above or below 7.8 kg (p = 0.72). Postoperative TOEs identified two cases needing further interventions, emphasizing its value in evaluating surgical outcomes and also for guiding percutaneous interventions.ConclusionOur comprehensive evaluation demonstrates that the new 3D pediatric TOE probe is feasible and provides high-quality imaging in pediatric patients. The successful integration of this novel probe into clinical practice has the potential to enhance diagnostic accuracy and procedural planning, ultimately optimizing patient outcomes in pediatric cardiac care.
Correlation between visceral fat metabolism score and erectile dysfunction: a cross-sectional study from NHANES 2001-2004
Authors: Huang Lewei , Liu Heqian , Li Lianqiang , Wang Shudong , Sun Gang 
Published: December 2023

BackgroundsThe factors associated with erectile dysfunction (ED) are diverse, and obesity is a significant component. Metabolic Score for Visceral Fat (METS-VF) can assess obesity more accurately than body mass index (BMI). However, the association between METS-VF and ED remains unclear.ObjectiveThis study aimed to investigate the association between the METS-VF and ED using National Health and Nutrition Examination Survey (NHANES) 2001-2004 data.MethodsData were sourced from NHANES 2001-2004. The relationship between METS-VF and ED was analyzed using multivariate logistic regression, followed by subgroup analyses to identify sensitive populations. Nonlinear correlation was evaluated through smoothed curve fitting, and a threshold effect analysis validated the findings. Comparative logistic regression of the Receiver Operating Characteristic (ROC) curve assessed the diagnostic capability of METS-VF against the classical obesity index for ED.ResultsThe study enrolled 3625 participants, of whom 961 self-reported ED history and 360 reported severe ED. After adjusting for confounders, METS-VF exhibited a positive association with asthma prevalence (OR= 3.47, 95% CI: 2.83, 14.24). Stratification based on median METS-VF revealed higher ED prevalence in participants with elevated METS-VF (OR= 2.81,95% CI:2.32, 3.41). Nonlinear correlation was observed, with a significant association between METS-VF and ED when METS-VF exceeded 6.63. Subgroup analysis highlighted a stronger correlation in participants aged 50-85 years, Caucasians, hypertensive individuals, diabetics, and those with coronary heart disease. Sensitivity analysis using severe ED as the outcome reaffirmed the nonlinear positive association with METS-VF (OR=3.86, 95% CI:2.80,5.33), particularly when METS-VF surpassed 6.68.ConclusionElevated METS-VF was nonlinearly correlated with increased ED incidence. Individuals with METS-VF above 6.63 should be vigilant about heightened ED risk. Special attention should be given to participants aged 50-85 years, Caucasians, hypertensive individuals, diabetics, and those with coronary heart disease.
The effect of hypothyroidism on the risk of diabetes and its microvascular complications: a Mendelian randomization study
Authors: Fang Ting , Deng Xiaoqing , Wang Jingyi , Han Fei , Liu Xiangyang , Liu Yajin , Sun Bei , Chen Liming 
Published: December 2023

ContextSeveral observational studies have found that hypothyroidism is associated with diabetes and its microvascular complications. However, the cause and effect have not been clarified.ObjectiveThe aim of the study was to examine the causality of such associations by a Mendelian randomization study.MethodsTwo-sample Mendelian randomization analysis was conducted to investigate the associations. Summary statistics for hypothyroidism were from the UK Biobank, and diabetes and its microvascular complications were from the largest available genome-wide association studies. MR–Egger, weighted median, inverse variance weighted, simple mode and weighted mode were used to examine the causal associations, and several sensitivity analyses were used to assess pleiotropy.ResultsInverse variance weighted estimates suggested that hypothyroidism was associated with type 1 diabetes and type 1 diabetes with renal complications (β= 9.059926, se= 1.762903, P = 2.76E-07 and β= 10.18375, se= 2.021879, P = 4.73E-07, respectively) but not type 2 diabetes and type 2 diabetes with renal complications. In addition, hypothyroidism was positively associated with severe nonproliferative diabetic retinopathy and proliferative diabetic retinopathy (β= 8.427943, se= 2.142493, P = 8.36E-05 and β= 3.100939, se= 0.74956, P=3.52E-05, respectively).ConclusionsThe study identified the causal roles of hypothyroidism in diabetes and its microvascular complications. Hypothyroidism can lead to type 1 diabetes, type 1 diabetes with renal complications, severe nonproliferative diabetic retinopathy and proliferative diabetic retinopathy.
Investigating the occurrence of autoimmune diseases among children and adolescents hospitalized for Mycoplasma pneumoniae infections
Authors: Ha Eun Kyo , Kim Ju Hee , Cha Hye Ryeong , Han Bo Eun , Shin Youn Ho , Baek Hey-Sung , Choi Sun Hee , Han Man Yong 
Published: December 2023

BackgroundMycoplasma pneumoniae infection is common in the general population and may be followed by immune dysfunction, but links with subsequent autoimmune disease remain inconclusive.ObjectiveTo estimate the association of M. pneumoniae infection with the risk of subsequent autoimmune disease.MethodsThis retrospective cohort study examined the medical records of South Korean children from 01/01/2002 to 31/12/2017. The exposed cohort was identified as patients hospitalized for M. pneumoniae infection. Each exposed patient was matched with unexposed controls based on birth year and sex at a 1:10 ratio using incidence density sampling calculations. The outcome was subsequent diagnosis of autoimmune disease, and hazard ratios (HRs) were estimated with control for confounders. Further estimation was performed using hospital-based databases which were converted to a common data model (CDM) to allow comparisons of the different databases.ResultsThe exposed cohort consisted of 49,937 children and the matched unexposed of 499,370 children. The median age at diagnosis of M. pneumoniae infection was 4 years (interquartile range, 2.5–6.5 years). During a mean follow-up time of 9.0 ± 3.8 years, the incidence rate of autoimmune diseases was 66.5 per 10,000 person-years (95% CI: 64.3–68.8) in the exposed cohort and 52.3 per 10,000 person-years (95% CI: 51.7–52.9) in the unexposed cohort, corresponding to an absolute rate of difference of 14.3 per 10,000 person-years (95% CI: 11.9–16.6). Children in the exposed cohort had an increased risk of autoimmune disease (HR: 1.26; 95% CI: 1.21–1.31), and this association was similar in the separate analysis of hospital databases (HR: 1.25; 95% CI 1.06–1.49).ConclusionM. pneumoniae infection requiring hospitalization may be associated with an increase in subsequent diagnoses of autoimmune diseases.
Human neutrophil extracellular traps do not impair in vitro Toxoplasma gondii infection
Authors: Macedo Isabela S. , Lara Flávio A. , Barbosa Helene S. , Saraiva Elvira M. , Menna-Barreto Rubem F. S. , Mariante Rafael M. 
Published: December 2023

IntroductionToxoplasma gondii, responsible for causing toxoplasmosis, is a prevalent food and waterborne pathogen worldwide. It commonly infects warm-blooded animals and affects more than a third of the global human population. Once ingested, the parasite enters the host’s small intestine and rapidly disseminates throughout the body via the bloodstream, infiltrating various tissues. Leukocyte-driven responses are vital against T. gondii, with neutrophils playing a dual role: swiftly recruited to infection sites, releasing inflammatory mediators, and serving as a replication hub and Trojan horses, aiding parasite spread. Neutrophils from various hosts release extracellular traps (NETs) against the protozoan. However, gaps persist regarding the mechanisms of NETs production to parasite and their significance in infection control. This study investigates the interplay between human neutrophils and T. gondii, exploring dynamics, key molecules, and signaling pathways involved in NETs production upon protozoan challenge.Methods and ResultsUsing confocal and electron microscopy, live cell imaging, pharmacological inhibitors, and DNA quantification assays, we find that human neutrophils promptly release both classical and rapid NETs upon pathogen stimulation. The NETs structure exhibits diverse phenotypes over time and is consistently associated with microorganisms. Mechanisms involve neutrophil elastase and peptidylarginine deiminase, along with intracellular calcium signaling and the PI3K pathway. Unexpectedly, human traps do not diminish viability or infectivity, but potentially aid in capturing parasites for subsequent neutrophil phagocytosis and elimination.DiscussionBy revealing NETs formation mechanisms and their nuanced impact on T. gondii infection dynamics, our findings contribute to broader insights into host-pathogen relationships.
Durability of geopolymer stabilized domestic waste incineration slag blending macadam in pavement base
Authors: Ji Xiaoping , Mou Keliang , Zhang Ting , Dong Xinze 
Published: December 2023

In order to achieve the high quality and large-scale utilization of domestic waste incineration slag (WIS) in pavement base, a geopolymer prepared using fly ash from domestic waste incineration was used to replace the cement to stabilized WIS blending macadam used in the pavement base. The durability of the geopolymer stabilized WIS blending macadam (called as GeoWIS) was investigated, including the water stability, freeze-thaw resistance and dry shrinkage. The strength formation was identified using SEM analyses. Furthermore, the durability of GeoWIS was investigated and compared with those of cement stabilized macadam (CSM). Results show that the 7 days compressive strength of GeoWIS meets the strength criterion of the asphalt pavement base (≥2 MPa), except for the combination of 8% geopolymer and 100% WIS. The water stability coefficient and residual compressive strength ratio of GeoWIS increase as the geopolymer increases and WIS decreases. The cumulative dry shrinkage and dry shrinkage coefficient decrease as the WIS increases, while the cumulative water loss rate of GeoWIS increases. SEM analysis shows that the geopolymer reaction generates C-S-H gels, N-A-S-H gels, and Aft, which is the source of the GeoWIS strengths. GeoWIS has better water stability than CSM, and its freeze-thaw resistance and average dry shrinkage coefficient are lower than the average values for CSM.