bluuebunny/crossref_metadata_2025_split huggingface dataset:
A CFRP Passenger Floor Stanchion Underwent Dynamic Buckling Structural Testing
Authors: Mauro G. Di , Guida M. , Ricci F. , Maio L. 
Published: December 2023

Abstract

The work focuses on the study of the structural behaviour of a composite floor beam in the cargo area of a commercial aircraft subjected to static and dynamic loads (typical of hard or crash landing). Experimental tests have been performed in the laboratories of the Dept. of Industrial Engineering (UniNA) jointly with the development of numerical models suitable to correctly simulate the phenomenon through the LS-DYNA software. The definition of a robust numerical model allowed to evaluate the possibility of buckling triggering. The test article was equipped with potting supports on both ends of the tested beam, filling the pots with epoxy resin toughened with glass fiber nanoparticles. This allowed to uniformly load the beam ends in compression and to carry out the tests loading the specimen statically and dynamically, to observe the differences in the behaviour of the beam under two different types of applied load. The result obtained through the comparison between the numerical model and the experimental test was that the dynamic buckling was triggered by a quantitatively smaller load than in the static case. Furthermore, it has been observed that the experimental compressive displacement to trigger the dynamic buckling instability was greater than the displacement observed in the static case.
Efficacy and safety of percutaneous balloon compression for bilateral trigeminal neuralgia： a retrospective study
Authors: Wang Yinzhan , Guo Wenchang , Du Yihui , Li Yang , Shi Haowei , Qian Tao 
Published: December 2023

Abstract
Background Percutaneous balloon compression（PBC）of the Gasserian ganglion is steadily gaining traction within the trigeminal neuralgia（TN）community. Bilateral trigeminal neuralgia（BTN） is a rare condition, and its treatment remains challenging. As far as we know, there are currently no research reports on the treatment outcomes of PBC for BTN.The purpose of this study is to meticulously evaluate the efficacy and safety of PBC for BTN in our medical institution.
Methods In this retrospective study, we collected and analyzed the medical records of all patients with BTN who underwent the PBC procedure at the Department of Neurosurgery at Hebei General Hospital from July 2017 to July 2023. After undergoing PBC therapy, all patients were promptly assessed for treatment efficacy based on the modified Barrow Neurological Institute (BNI) pain intensity grading scale.
Results All 37 patients with BTN experienced significant pain relief (BNI I-IIIb) immediately following unilateral PBC treatment. Among these patients, 25 reported relief from pain on the non-operative side, which was effectively managed with medication. Out of the 12 patients who did not experience improvement in contralateral symptoms, 11 received contralateral PBC. Out of the 48 treated sides, 47 sides (97.9%) achieved excellent pain control following a single PBC procedure. The follow-up times ranged from 2 to 62 months.The cumulative survival after PBC was 100%, 90.2%, and 80.2% within 1, 3, and 5 years, respectively.Three recurrent patients underwent repeated unilateral PBC, and all of them maintained excellent pain control postoperatively. At the last follow-up, satisfaction was at 91.7% (measured using the Likert scale), with no severe complications occurring.
Conclusions The results indicate that PBC is an effective and relatively safe method for treating BTN, offering a valuable option for pain control in these rare cases of TN.
Predictive factors of pathological lateral pelvic lymph node metastasis in patients with selective laparoscopic lateral lymph node dissection for rectal cancer:A retrospective Study
Authors: Yang Yugang , Xue Xiajuan , Shen Huiqun , Xu Xiaozhen , Cai Mingzhi , Guo Yincong 
Published: December 2023

Abstract
Background:In recent years, selective lateral lymph node dissection（LLND） has been recognized by more and more surgeons.However, the indication for this procedure remains unclear.
Purpose: We aimed to identify the predictive factors for pathological lateral pelvic lymph nodes metastasis(LPNM) and the indications for lateral pelvic lymph node dissection.
Methods: This study involved 55 patients with locally advanced rectal cancer and clinically suspected lateral pelvic lymph nodes(LPN) metastasis who underwent total mesorectal excision（TME）with LLND between December 2019 and October 2023. According to pathological findings, they were divided into negative LPN (n=35) and positive LPN(n=20) groups. Primary endpoints were overall pathologic positive rate and risk factors of pathological LPNM.
Results: Among 55 patients, 20 (36.4%) had pathologically confirmed lateral pelvic lymph node metastasis. Initial short-axis diameter of LPN (≥7mm,p=0.003), imagie risk factors (≥3,p=0.008), LLND time (heterochronism,p=0.014),distant metastasis(yes,p=0.005) and p-N stage(N2,p＜0.001) were significantly associated with pathological LPNM. Initial short-axis diameter of LPN (p=0.012,OR 12.732,95%CI 1.768-91.699) and p-N stage(p=0.010,OR 13.650,95%CI 2.658-95.380) were independent risk factors for pathological LPNM in multivariable analysis furtherly.
Conclusion: Initial short-axis diameter of LPN and p-N stage were significant predictors of lateral pelvic lymph node metastasis. This study recommended that initial short-axis diameter of LPN ≥7 mm as a Cut-off value for selective LLND.
Calpeptin mitigates ventriculomegaly and microvascular impairment in a novel LPS- dependent mouse model of acquired hydrocephalus
Authors: Ledbetter Jenna , Lee Seunghyun , Sato Sora , Jison Gio , Romero Bianca , Shahriari Amirhossein , Padilla Alejandra , Torres Evelyn , Tran Celine , Muhonen Michael , Castañeyra-Ruiz Leandro 
Published: December 2023

Abstract
Hydrocephalus, characterized by ventricular distension due to impaired cerebrospinal fluid (CSF) pathways, is a multifactorial condition with perinatal infection as a predominant global cause. Over three decades, alterations in periventricular cell junctions, especially cadherins, have been linked to pediatric hydrocephalus pathogenesis. We propose that the Toll-like receptor (TLR)–calpain (calcium-dependent proteinase) pathway induces cadherin cleavage, playing a central role in initiating vascular impairment associated with vascular permeability and ventriculomegaly—hallmark events in acquired hydrocephalus (AH).
In this manuscript, perinatal C57BL/6 mice and endothelial cell cultures were exposed to lipopolysaccharide (LPS) toxin, a gram-negative bacteria component, modeled post-infectious hydrocephalus. For treatment, calpain inhibitor (calpeptin) and TLR-4 receptor inhibitor were employed in cell cultures, with calpeptin used in mice. Magnetic resonance imaging (MRI) quantified ventricular volume, and immunofluorescence and DiI assessed microvascular integrity. Additionally, endothelial permeability was evaluated using a transwell system.
Results showed that in vitro LPS induced increased endothelial permeability associated with calpain-dependent cleavage of VE-cadherin. In vivo, intraventricular LPS-induced ventriculomegaly linked to microvascular impairments dorsally to the ventricles (p<0.05). In vitro, TLR and calpain inhibition exhibited similar vascular permeability and VE-cadherin cleavage after LPS exposure compared to the control. In vivo, calpain inhibition prevented or attenuated ventriculomegaly and significantly improved survival after LPS injection (p<0.05).
This research offers a comprehensive analysis from in vitro experiments on C57BL/6 mice primary brain microvascular endothelial cells to in vivo mouse models, highlighting the pivotal role of the TLR4-Calpain pathway, VE-cadherin cleavage, and vascular impairment in acquired hydrocephalus pathogenesis. The findings emphasize the potential of calpain inhibition in preventing the physiopathology associated with LPS exposure.
Targeting mTOR and Survivin Concurrently Potentiates Radiation Therapy in Renal Cell Carcinoma by Suppressing DNA Damage Repair and Amplifying Mitotic Catastrophe
Authors: Rachamala Hari K. , Madamsetty Vijay S. , Angom Ramcharan S. , Nakka Naga M. , Dutta Shamit Kumar , Wang Enfeng , Mukhopadhyay Debabrata , Pal Krishnendu 
Published: December 2023

Abstract
Background
Renal cell carcinoma (RCC) was historically considered to be less responsive to radiation therapy (RT) compared to other cancer indications. However, advancements in precision high-dose radiation delivery through single-fraction and multi-fraction stereotactic ablative radiotherapy (SABR) have led to better outcomes and reduced treatment-related toxicities, sparking renewed interest in using RT to treat RCC. Moreover, numerous studies have revealed that certain therapeutic agents including chemotherapies can increase the sensitivity of tumors to RT, leading to a growing interest in combining these treatments. Here, we developed a rational combination of two radiosensitizers in a tumor-targeted liposomal formulation for augmenting RT in RCC. The objective of this study is to assess the efficacy of a tumor-targeted liposomal formulation combining the mTOR inhibitor everolimus (E) with the survivin inhibitor YM155 (Y) in enhancing the sensitivity of RCC tumors to radiation.
Experimental Design:
We slightly modified our previously published tumor-targeted liposomal formulation to develop a rational combination of E and Y in a single liposomal formulation (EY-L) and assessed its efficacy in RCC cell lines in vitro and in RCC tumors in vivo. We further investigated how well EY-L sensitizes RCC cell lines and tumors toward radiation and explored the underlying mechanism of radiosensitization.
Results
EY-L outperformed the corresponding single drug-loaded formulations E-L and Y-L in terms of containing primary tumor growth and improving survival in an immunocompetent syngeneic mouse model of RCC. EY-L also exhibited significantly higher sensitization of RCC cells towards radiation in vitro than E-L and Y-L. Additionally, EY-L sensitized RCC tumors towards radiation therapy in xenograft and murine RCC models. EY-L mediated induction of mitotic catastrophe via downregulation of multiple cell cycle checkpoints and DNA damage repair pathways could be responsible for the augmentation of radiation therapy.
Conclusion
Taken together, our study demonstrated the efficacy of a strategic combination therapy in sensitizing RCC to radiation therapy via inhibition of DNA damage repair and a substantial increase in mitotic catastrophe. This combination therapy may find its use in the augmentation of radiation therapy during the treatment of RCC patients.
The changing role of family as provider of intergenerational support during COVID- 19: a longitudinal study into the mental health consequences for older Europeans
Authors: Herreweghe Lore Van , Lancker Wim Van 
Published: December 2023

Abstract

Intergenerational support is an important determinant of mental health for all family members involved. Due to limited access to formal care, the role of the family as provider of support became more prominent during the COVID-19 pandemic. To date, it remains unclear how intergenerational support from adult children to older parents was affected during the pandemic and whether this had consequences for the mental health of the parent generation. Using data from the Survey of Health, Ageing and Retirement (SHARE) Corona Surveys, we explore whether changes in support going from non-coresident adult children to their parents are associated with parents’ changes in depressive feelings. Additionally, we test whether the pandemic context and stringency of public health measures affected this relationship. Families responded to the increased needs of elderly parents by providing more informal support. These changes in intergenerational support, however, were related to increased depressive feelings for the older parents. Furthermore, both the strictness of public health measures and the concurrent epidemiological situation affected this relationship. We conclude that the family is an essential source of late-life well-being. But, stressful life events such as public health crises put pressure on these intergenerational relations with potential adverse mental health outcomes. Future policies should take into account the ambivalent nature of intergenerational relationships.
Endovascular repair in patients with aortic dissection and aortic aneurysm: A retrospective cohort study.
Authors: Alvarez-Covarrubias Hector A. , Uribe-González Jhonathan , Montoya-Guerrero Silvestre A. , Saturno-Chiu Guillermo , Estrada-Gallegos Joel 
Published: December 2023

Abstract

Background
Therapeutic options in patients with aortic diseases include medical treatment, surgical and percutaneous intervention. The latter has been proved to be safe in patients with aortic aneurysm (AA) and aortic dissection (AD), but still represents challenging and with significant mortality rates. For these reasons, we aimed to compare procedural and in-hospital complications in patients with AA and AD treated with transfemoral transcatheter endovascular aortic repair (EVAR).
Methods
Patients treated using transfemoral EVAR from 2012 to 2017 at the Hospital de Cardiología, Centro Médico Nacional Siglo XXI, Mexico City with complete computed tomography (CT) and diagnostic of AA and AD were included. Procedural and in-hospital related complications were compared among patients treated due to AA and AD. Endpoints of the study were in-hospital and thirty days all-cause mortality and any cause of readmission.
Results
A total of 38 patients with high quality CT were included in the analysis. From them, 25 had AA and 13 AD. Mean age was 64 ± 14 yeas, 23.7% were females. Urgent treatment was required in 31.6%, the number of prosthesis used was 2.13 [1, 5] per patients. No in-hospital mortality was observed. Type 1a endoleak was similar in both groups (AA 8% vs. AD 15.4%, p = 0.59). Conversion to surgery was needed only in one patient (AA 4% vs AD 0%, p > 0.99). No difference was observed regarding endovascular reintervention (16% vs. 15.4%, p > 0.99), graft thrombosis (12% vs. 0%, p = 0.53), spinal cord injury (0% vs. 15.4%, p = 0.11) or vascular complication (8% vs. 15.4%, p = 0.59%) between AA and AD respectively. No 30-days mortality was observed.
Conclusions
EVAR represents a safe procedure in patients presenting with AA or AD, with no in-hospital or 30 days mortality rate and very low reintervention rate.
Indirubin in Vitro Apoptotic Effect Towards Chronic Lymphocytic Leukaemia (CLL) Lineage
Authors: Jafarinejad Habib , Yarmohammadi Reyhaneh , Piccin Andrea , Aghaie Afsaneh , Rostami Tahereh , Faranoush Mohammad , Hemmati Maral , nikroo Nikta Dadkhah , Moghadam Bijan Sedighi , Kokhaie Parviz 
Published: December 2023

Abstract
Chronic lymphocytic leukemia (CLL) is a chronic condition that usually affects elderly people. The etiology is unknown, however the current hypothesis is that over time the haematopoietic stem cells may acquire mutations that will lead to irregularity in apoptotic mechanism (e.g. BCL2 mutation). Dangui Luhui Wan consist in mix of 11 herbs used by the Chinese Medicine. This herbal compound has proven to have antitumoral activities on various types of cancer cells. A derivate from Dangui Luhui Wan is indirubin-3'-monoxime (I3M). This substance act as selective inhibitor of cyclin-dependent kinases (CDKs) and can induce cell apoptosis. The aim of this study was to test the efficacy of I3M against CLL cells in vitro. We evaluated the expression of apoptotic proteins Bcl2/Bax and CDK1/2 using real-time PCR. Peripheral mononuclear cells (PBMCs) obtained from 14 patients were treated with 20 μM of I3M for 48hrs. After treatment a reduced Bcl-2 expression was noticed. No significant changes were seen for Bax. However, an increased Bax/Bcl-2 ratio was documented, suggesting that mitochondrial pathway is involved in I3M apoptotic-mechanism of action. Interestingly, I3M could inhibit the expression of CDK2, while it does not affect the expression of CDK1. These results indicated that I3M exerts anti-tumor effects through induction apoptosis and inhibition of CDK2. Further studies are now needed to clarify the exact mechanism of action of I3M in CLL and possibly in other tumoral cell lines.
Interaction between alcohol drinking status and hay fever on atopic dermatitis: NHANES 2005–2006
Authors: Ding Qike , lin Lihong , Li Xiaoting , jing Wenjuan , xie Xiaoping , chen Xinyu , chen Jiadong , Lu Tao 
Published: December 2023

Abstract
Background
hay fever may increase the risk of atopic dermatitis. However, few studies have investigated the joint effects of hay fever and alcohol drinking status on atopic dermatitis. Therefore, we aimed to explore the association between hay fever, atopic dermatitis, and alcohol drinking status.
Methods
4754 participants aged over 20 years from the National Health and Nutrition Examination Survey (NHANES) in 2005–2006 were involved in the study. Hay fever was defined by self-reported medical diagnosis, atopic dermatitis status was assessed by the question “Has a doctor or other health professional ever told you that you have eczema”, and alcohol drinking status was determined by the survey question, “In any 1 year, have you had at least 12 drinks of any type of alcoholic beverage?” Logistic regression, and stratified analysis of sub-groups were used in this study.
Results
hay fever was risk factor for atopic dermatitis. There was an interaction between hay fever and alcohol drinking status (P for interaction = 0.01). Hay fever was associated with increased risk of atopic dermatitis among the population who were alcohol non-drinkers. Compared with the population who were alcohol drinkers and without hay fever, the OR of atopic dermatitis was 3.71 (1.74, 7.90) for the population who were alcohol non-drinkers and with hay fever.
Conclusions
There was a positive interaction between hay fever and alcohol drinking status on atopic dermatitis. Alcohol may attenuate the detrimental impacts of hay fever on atopic dermatitis.
Neoadjuvant chemoradiotherapy is associated to higher postoperative complications and inferior long-term oncological survival outcomes in patients with proximal rectal cancers when compared with upfront surgery
Authors: Aliyev Vusal , Shadmanov Niyaz , Piozzi Guglielmo Niccolò , Bakır Barıs , Goksel Suha , Asoglu Oktar 
Published: December 2023

Abstract
Background
The role of preoperative chemoradiotherapy (CRT) in the management of proximal rectal cancer (PRC) is still debated. The purpose of this study was to compare perioperative and long-term oncological outcomes between PRC patients undergoing CRT + surgery and upfront surgery.
Methods
A total of 157 patients were retrospectively included in this study (131 treated with upfront surgery and 26 with CRT). CRT and upfront surgery groups were compared in terms of perioperative and long-term oncological outcomes.
Results
CRT group of patients was associated with higher rate of overall postoperative complications (42.3% vs. 18.3%, p < 0.05) and class III-IV complications (15.4% vs. 8.4%, p < 0.05). The 3 and 5-years overall survival (OS) rates for upfront surgery and CRT group were: 96.1%, 91.5% and 95.8%, 71.7% (p < 0.05), respectively. The 3 and 5-years disease-free survival (DFS) rates for upfront surgery and CRT were: 92.4%, 86.8% and 90.6%, 68.6% (p < 0.05), respectively.
Conclusion
The omission of CRT in patients with PRC did not impair the perioperative and long-term oncological outcomes. CRT is associated to higher complications rates and severity and to worst OS and DFS.
Comparative study on the application of tarsal tunnel block and spinal anesthesia in open osteotomy of hallux valgus
Authors: jia hong , Chen Yong-Feng , Wang Hua-Yi , sun qiang , wang yuan-rui , Zhang da 
Published: December 2023

Abstract
Background
Hallux valgus is a common and frequently occurring forefoot disease. Surgical treatment is often required for moderate to severe cases, and the choice of anesthesia during surgery significantly impacts postoperative functional recovery. This study aims to explore a more suitable anesthesia method for open hallux valgus surgery.
Methods
A total of 90 patients with hallux valgus admitted to the hospital from November 2016 to November 2020 were randomly divided into two groups: the tarsal tunnel block group and the spinal anesthesia group. Open osteotomy and internal fixation were performed on the first metatarsal and proximal phalanges using the anterolateral approach. Various observation indexes were set, and relevant data, including anesthesia operation time, anesthesia onset time, operation time, anesthesia duration, changes in vital signs during operation, fasting time, anesthesia complications, wound complications, hospitalization expenses, etc., were recorded. The VAS pain score questionnaire was filled out before and after the surgery, and a follow-up was conducted.
Results
The tarsal tunnel block group exhibited shorter operation and onset times of anesthesia, as well as longer duration of anesthesia effect. Moreover, fasting water was not required before or after the surgery, anesthesia complications were fewer, and patient activities were not affected. The difference between the two groups was statistically significant (P < 0.05).
Conclusion
The application of tarsal tunnel anesthesia instead of traditional spinal anesthesia in open hallux valgus surgery has a broader application range and can fully meet the clinical needs of open hallux valgus surgery.
Opportunistic screening for COPD among socially marginalized patients
Authors: Brünés Nina , Lindstroem Mette Bendtz , Ulrik Charlotte Suppli , Andersen Ove , Lisby Marianne , Godtfredsen Nina Skavlan , Hansen Tina Leth , Pisinger Charlotta , Graven Vibeke , Marsaa Kristoffer , Thomsen Laura Hohwü 
Published: December 2023

Abstract
Background
Chronic obstructive pulmonary disease (COPD) is a common disease associated with premature death. Tobacco exposure is the main risk factor, but lower socioeconomic status, early life insults, and occupational exposures are also among the risk factors. Smoking cessation and early detection of COPD are crucial in order to improve outcomes. Socially marginalized people, facing homelessness, substance use disorder, and mental illness, are likely to have a higher risk of developing COPD, and, furthermore, experience barriers to healthcare access and consequently poorer outcomes.
Objective
This study aims to assess COPD prevalence and impact of opportunistic screening among hospitalized patients who are in contact with hospital social nurses. These patients constitute a group of patients with a high prevalence of psychiatric and somatic diseases, substance use, low life expectancy, and are socially marginalized.
Methods
The present prospective longitudinal study includes a clinical examination at baseline. Participants will have spirometry done and participate in interviews regarding risk factors, socioeconomic conditions, and respiratory symptoms. The 5-year follow-up assessment incorporates data from baseline and register data over the five years, including information on morbidity, use of COPD medication, hospital contacts, mortality, and socioeconomic factors.
Anticipated results
Referral for further diagnostic work-up and management after the screening, including COPD treatment and smoking cessation support, is expected to improve survival rates. As the study is still enrolling patients there are no preliminary findings.
Trial Registration
The study is registered at ClinicalTrials.gov, NCT04754308 with study status: “enrolling”