bluuebunny/crossref_metadata_2025_split huggingface dataset:
Can foliar application of natural biostimulants reduce nitrate and fiber content in fresh green bean under soil nutrient deficiency?
Authors: Fawzy Zakaria Fouad , El-Ramady Hassan , Azab Mohamed AbdAllah , Mahdy Hayam A. A. 
Published: November 2023

Abstract
Background
There is a growing body of literature that recognizes the importance of natural biostimulants in the agricultural productivity. This potential can play an important role in addressing the issue of cultivation on sandy soil, which is well-known with soil nutrient deficiency stress. In the current study, the selected biostimulants (i.e., chitosan, amino acids, yeast extract, and humic acid) were foliar applied on green bean in the open field of alkaline sandy soils.

Results
The main results that obtained after harvesting the fresh green bean pods were confirmed that all studied biostimulants improved the quantity and quality of green bean production compared to the control. Chitosan was the best applied biostimulants for producing green bean in a lower fiber and nitrate content of pods, a higher crude protein content of pods, and higher NPK content in the leaves.

Conclusion
The role of studies biostimulants in promoting green bean productivity under nutrient deficiency stress may back to increase the uptake of nutrients (NPK), plant physiological (higher dry matter) and biochemical attributes (higher crude protein). More studies are needed using different applied doses and more different kinds of natural biostimulants.
Efficacy of polyherbal formulation along with standard care of treatment in early recovery of COVID-19 patients: a randomized placebo-controlled trial
Authors: Arun Abhishek , Subramanian Saumya , Kanchibhotla Divya 
Published: November 2023

Abstract
Background
The coronavirus disease-2019 (COVID-19) pandemic crisis has affected millions of people worldwide. The emergence of mutant strains one after the other, breakthrough infections post-vaccination and reinfection of the virus have made it difficult to fight the pandemic and bring an end to it. Naturally available compounds with an array of phytochemicals and potent antiviral properties can provide an alternate solution in improving innate immunity, early recovery and symptomatic cure from COVID-19.

Objective
The present study investigates the efficacy of a polyherbal formulation, NAOQ19, on the rate of recovery and clinical improvement among COVID-19-infected patients who were not on a ventilator or in intensive care unit.

Methods
A randomized placebo-controlled study design was adopted for the study. The study enrolled 124 patients with 62 patients included in the NAOQ19 arm and other 62 patients enrolled in the placebo arm along with standard care of treatment. Key outcomes of the study included improvement from COVID-19 based on RT-PCR negative test tested on day 3, 5, 7 and 10, CRP inflammatory rate and drug safety. Data analysis included intention to treat approach. Significance was accepted with a two-sided p value < 0.05 for the outcome measures.

Results
The results of the present study demonstrated higher proportion of patients recovering in NAOQ19 arm compared to placebo arm on day 3 (33.8% vs. 8%; p < 0.001). The mean number of days required to turn RT-PCR (Real-time reverse transcriptase-polymerase chain reaction) negative was also lower in NAOQ19 arm by a day compared to placebo arm (5.4 vs. 6.2; p = 0.022). Inflammatory marker CRP (C-reactive protein) significantly reduced in the NAOQ19 arm at exit compared to placebo arm (6.25 mg/L vs. 10.26 mg/L; p = 0.048). Liver function test and kidney function test profiles were within normal limits during exit demonstrating the drug safety.

Conclusion
NAOQ19 along with standard care of treatment demonstrated higher percentage of population recovering from COVID-19 in comparison with those who were on standard care of treatment.
Trial registration: The trial was also registered in Clinical Trial Registry India with registration number CTRI/2021/10/037423.
JAK-STAT signaling in inflammation and stress-related diseases: implications for therapeutic interventions
Authors: Sarapultsev Alexey , Gusev Evgenii , Komelkova Maria , Utepova Irina , Luo Shanshan , Hu Desheng 
Published: November 2023

AbstractThe Janus kinase-signal transducer and transcription activator pathway (JAK-STAT) serves as a cornerstone in cellular signaling, regulating physiological and pathological processes such as inflammation and stress. Dysregulation in this pathway can lead to severe immunodeficiencies and malignancies, and its role extends to neurotransduction and pro-inflammatory signaling mechanisms. Although JAK inhibitors (Jakinibs) have successfully treated immunological and inflammatory disorders, their application has generally been limited to diseases with similar pathogenic features. Despite the modest expression of JAK-STAT in the CNS, it is crucial for functions in the cortex, hippocampus, and cerebellum, making it relevant in conditions like Parkinson's disease and other neuroinflammatory disorders. Furthermore, the influence of the pathway on serotonin receptors and phospholipase C has implications for stress and mood disorders. This review expands the understanding of JAK-STAT, moving beyond traditional immunological contexts to explore its role in stress-related disorders and CNS function. Recent findings, such as the effectiveness of Jakinibs in chronic conditions such as rheumatoid arthritis, expand their therapeutic applicability. Advances in isoform-specific inhibitors, including filgotinib and upadacitinib, promise greater specificity with fewer off-target effects. Combination therapies, involving Jakinibs and monoclonal antibodies, aiming to enhance therapeutic specificity and efficacy also give great hope. Overall, this review bridges the gap between basic science and clinical application, elucidating the complex influence of the JAK-STAT pathway on human health and guiding future interventions.
Graphical Abstract
Radiation-induced Undifferentiated Malignant Pituitary Tumor After 5 Years of Treatment for Cushing Disease
Authors: Bakshi Gazal , Mishra Sunil Kumar , AR Vishnupriya , Singh Virendera Pal 
Published: November 2023

Abstract
The occurrence of a second neoplasm possibly constitutes an adverse and uncommon complication after radiotherapy. The incidence of a second pituitary tumor in patients irradiated for adrenocorticotropic hormone secreting pituitary adenoma is rare. We report a case of a 40-year-old female with Cushing disease who underwent surgical management followed by radiotherapy. After 5 years of initial treatment, an increase in tumor size was evident at the same location, with a significant interval growth of the parasellar component of the lesion. Histology revealed an undifferentiated highly malignant sarcoma. In the span of next 2 years, the patient was followed with 2 repeat decompression surgeries and radiotherapy because of significant recurrent compressive symptoms by locally invasive malignant tumor. Despite the best efforts, the patient remained unresponsive to multiple treatment strategies (eg, surgical resections and radiotherapy) and succumbed to death.
2022 Peritoneal Surface Oncology Group International Consensus on HIPEC Regimens for Peritoneal Malignancies: Colorectal Cancer
Authors: Hübner Martin , van Der Speeten Kurt , Govaerts Kim , de Hingh Ignace , Villeneuve Laurent , Kusamura Shigeki , Glehen Olivier 
Published: November 2023

Abstract
Background
Selected patients with peritoneal metastases of colorectal cancer (PM-CRC) can benefit from potentially curative cytoreductive surgery (CRS) ± hyperthermic intraperitoneal chemotherapy (HIPEC), with a median overall survival (OS) of more than 40 months.

Objective
The aims of this evidence-based consensus were to define the indications for HIPEC, to select the preferred HIPEC regimens, and to define research priorities regarding the use of HIPEC for PM-CRC.

Methods
The consensus steering committee elaborated and formulated pertinent clinical questions according to the PICO (patient, intervention, comparator, outcome) method and assessed the evidence according to the Grading of Recommendation, Assessment, Development, and Evaluation (GRADE) framework. Standardized evidence tables were presented to an international expert panel to reach a consensus (4-point, weak and strong positive/negative) on HIPEC regimens and research priorities through a two-round Delphi process. The consensus was defined as ≥ 50% agreement for the 4-point consensus grading or ≥ 70% for either of the two combinations.

Results
Evidence was weak or very weak for 9/10 clinical questions. In total, 70/90 eligible panelists replied to both Delphi rounds (78%), with a consensus for 10/10 questions on HIPEC regimens. There was strong negative consensus concerning the short duration, high-dose oxaliplatin (OX) protocol (55.7%), and a weak positive vote (53.8–64.3%) in favor of mitomycin-C (MMC)-based HIPEC (preferred choice: Dutch protocol: 35 mg/m2, 90 min, three fractions), both for primary cytoreduction and recurrence. Determining the role of HIPEC after CRS was considered the most important research question, regarded as essential by 85.7% of the panelists. Furthermore, over 90% of experts suggest performing HIPEC after primary and secondary CRS for recurrence > 1 year after the index surgery.

Conclusions
Based on the available evidence, despite the negative results of PRODIGE 7, HIPEC could be conditionally recommended to patients with PM-CRC after CRS. While more preclinical and clinical data are eagerly awaited to harmonize the procedure further, the MMC-based Dutch protocol remains the preferred regimen after primary and secondary CRS.
Hyperventilation in cardiac arrest—a systematic review and narrative synthesis
Authors: Kirk Benjamin , McClelland Graham , Hepburn Sarah 
Published: November 2023

Background: Resuscitation guidelines recommend delivering ventilations at a rate of 10 per minute. However, hyperventilation is commonly reported during out-of-hospital cardiac arrest resuscitation efforts, and the impact of this on patient outcomes is unclear. This review explores the reported rates, causes and patient outcomes of hyperventilation in the management of out-of-hospital cardiac arrest. Methods: A systematic literature review with a narrative synthesis of three databases was carried out. Findings: Thirteen papers met the eligibility criteria. These showed that ventilations were consistently delivered at a higher rate and tidal volume than are internationally recommended. Hyperventilation can occur because of clinician stress, a lack of situational awareness and a focus on other clinical interventions as well as poor leadership. Conclusion: Hyperventilation is common during cardiac arrest management. Currently available human data do not produce sufficient evidence to favour any ventilation strategy; however, a harmful upper limit will exist. This review found no human randomised control studies examining how ventilation rate, tidal volume or pressure affect patient outcomes and this warrants further research.
AVALIAÇÃO DO REGISTRO DE ENFERMAGEM SOBRE PARADA CARDIORRESPIRATÓRIA E REANIMAÇÃO CARDIOPULMONAR COMPARADO AO MODELO UTSTEIN
Authors: Oliveira Santos Andressa , Matos Amaral Jocelio , Da Silva Teixeira Loren Scarlatt , Neves Ribeiro Regina , Steffens Ana Paula 
Published: November 2023

Introdução: Os casos de Parada Cardiorrespiratória devem ser registrados de forma completa e detalhada, desde a sua causa até as intervenções realizadas a fim de obter o retorno da circulação espontânea. Objetivo: Avaliar a qualidade dos registros de enfermagem sobre parada cardiorrespiratória e reanimação cardiopulmonar com base no modelo Utstein. Materiais e métodos: Estudo transversal, exploratório - descritivo, quantitativo, realizado em duas Unidades de Terapia Intensiva, com avaliação em prontuário de registros de parada cardiorrespiratória e reanimação cardiopulmonar com retorno da circulação espontânea ou óbito, pelo período de dois meses. Resultados: Foram avaliados 41 registros, de pacientes com idade entre 22 e 79 anos, sendo 14 (51,9%) homens. Em 13 (31,7%) registros não havia descrição de quaisquer manobras de reanimação e, quando descritos, na maioria deles não havia especificação das intervenções realizadas. A descrição da causa da parada cardiorrespiratória estava ausente em 38 (92,7%) e do ritmo em 37 (90,3%) registros. Em mais da metade não havia registros dos tempos dos eventos e nem um mencionava quais os profissionais envolvidos na reanimação cardiopulmonar. Conclusão: Todas as anotações estavam incompletas frente ao modelo Utstein, isso dificulta a obtenção de dados para realização de pesquisas sobre a temática e expõe a precariedade do registro realizado sem método sistemático.
LA CULTURA CINEMATOGRÁFICA ALEMANA CON TRASFONDO MIGRATORIO. FATIH AKIN Y SU TRANSCULTURALIDAD
Authors: SALMERÓN MATILLA ANTONIO 
Published: November 2023

La emigración turca en Alemania hacia mitad del siglo XX trascendió de tal forma que surgieron historias de ficción y no ficción en las distintas artes, incluido el cine. Este trabajo se centra en el “cine de migraciones” o “cine turco-alemán”, referido a minorías étnicas. El objetivo principal es descubrir otra mirada peculiar y personal del cineasta Fatih Akin, como uno de los máximos exponentes del cine contemporáneo alemán con trasfondo migratorio. Para este estudio se utiliza una metodología analítica y crítica tanto del llamado cine turco-alemán como de una gran parte de las películas del cineasta que nos ocupa. En el análisis se cuestiona su evolución y caracterización hasta hoy en día. Como resultados más relevantes es posible identificar este cine y a este director como transcultural.
Understanding the needs of women undergoing breast ultrasound: Are male radiologists still needed?
Authors: Sartoretti Elisabeth , Largiadèr Selina , Sartoretti Thomas , Laures Simin , Walter Martin Alexander , Monti Eva , Füchsel Ina , Dettling Mira , Pfister Stephan , Dubsky Peter , Ort Alexander , Sartoretti-Schefer Sabine , Meissnitzer Matthias , Hergan Klaus , Forstner Rosemarie , Matoori Simon , Bech- Hohenberger Rasmus , Froehlich John M. , Plümecke Tino , Harder Dorothee , Koh Dow Mu , Gutzeit Andreas 
Published: November 2023

Introduction
A trend towards less male radiologists specializing in breast ultrasound was observed. A common notion in the field of breast radiology is, that female patients feel more comfortable being treated by female radiologists. The aim of the study was to understand and report the needs of women undergoing breast ultrasound with regards to the sex of the radiologist performing the investigation.

Methods
Informed consent was obtained from all patients prior to inclusion in a prospective bi-center quality study. At center 1 (72 patients), the women were examined exclusively by female radiologists, at center 2 (100 patients) only by male radiologists. After the examination the patients were asked about their experiences and their wishes for the future.

Results
Overall, women made no distinction between female and male radiologists; 25% of them wanted a female radiologist and 1.2% wanted a male radiologist. The majority (74%) stated that it made no difference whether a female or male radiologist performed the examination. The majority of women in group 2, who were investigated exclusively by male radiologists, stated that they had no preferences with regard to the sex of the radiologist (93%); 5% of the women wished to be investigated solely by a female radiologist and 2% exclusively by a male radiologist.

Discussion
The majority of women undergoing breast ultrasound are unconcerned about the radiologist’s sex. It would appear that women examined by male radiologists are less selective about the sex of the examining radiologist.

Trial registration
Written informed consent was obtained from all patients. All patient data were anonymized. The physicians had no access to any further personal data. National regulations did not require dedicated ethics approval with anonymized lists or retrospective questionnaires.
Assessment of knowledge and attitude of pregnant women towards antenatal ultrasound in University of Gondar comprehensive specialized hospital at antenatal care clinic, Northwest Ethiopia
Authors: Mengistie Belayneh , Ayele Sileshi , Tsehaye Winta , Mazengia Atsede , Wolde Maereg 
Published: November 2023

Background
Obstetric ultrasound is one of the most important advances in antenatal tests. Despite the importance of knowing the knowledge status of ultrasound and the category of attitude, there is no similar study done in Ethiopia. Thus, this study aimed to assess knowledge and attitude and associated factors toward ultrasound examination at the University of Gondar comprehensive specialized hospital, Northwest Ethiopia.

Methods
Institutional-based cross-sectional study was conducted at the University of Gondar comprehensive specialized hospital, Northwest Ethiopia from May 15, 2022, to Jun 30, 2022. Data was collected and transferred from the Open data Kit server and analyzed using STATA version 14. The strength of the association, presented using an adjusted odds ratio with a 95% confidence interval and p-value ≤0.05, is considered to declare statistically significant variables.

Results
A total of 422 pregnant women participated, with a response rate of 100%. Of the total pregnant women, only 39% of them are knowledgeable about obstetric ultrasound whereas 52% of them have a favorable attitude. Being a housewife, government employee, and private employee (AOR = 17, 95% CI = 2.12, 151), (AOR = 10, 95% CI = 1.2, 85) and (AOR = (13, 95% CI = 1.5, 115), respectively were associated positively with knowledge about ultrasound. However, residing in a rural (AOR = 0.07; 95%CI = 0.02, 0.21), never been pregnant before (AOR = 0.59 95% CI = 0.38, 0.94), and having information (AOR = 1.7, 95% CI = 1, 2.9) were negatively associated with knowledge about ultrasound. Whereas, attaining primary education (AOR = 2.61; 95%CI = 1.1, 6.4) was positively associated with favorable attitudes while living in rural areas was negatively associated with a favorable attitude (AOR = 0.42; 95%CI = 0.18, 0.97).

Conclusion
In this study, knowledge and attitude about ultrasound among pregnant women in Gondar City are low. Residence, occupation, being pregnant before, and having information were significantly associated factors of knowledge. While residence and educational status of the respondents were significant factors of attitude. Therefore, health information about obstetric ultrasound shall be given to women who live in rural areas, women who are students, merchants and farmers, illiterate, and primigravida.
FAIRe Geodaten aus dem Archiv. Ein Tool zur automatisierten Metadatenextraktion aus historischen Karten
Authors: Hartmann André , Herold Hendrik , Schwartz Anna Lisa , Schmalzl Markus 
Published: November 2023

Zusammenfassung
In einem von der NFDI4Biodiversity geförderten Kooperationsprojekt der Generaldirektion der Staatlichen Archive Bayerns (GDA) und des Leibniz-Instituts für ökologische Raumentwicklung (IÖR) wurden Möglichkeiten der Verbesserung der Zugänglichkeit und Interoperabiltiät historischer Geoinformationen erprobt. Ziel des Projektes war die Erarbeitung von Digitalisierungsempfehlungen für historische Karten aus Archivbeständen und die Entwicklung sowie der Pilotbetrieb eines Tools zur Mobilisierung und FAIRification von analoggebundenen Informationen. Die über die Extraktion von Karteninhalten gewonnen Geo- und Metadaten bedienen verschiedene Standards und stehen somit neben der Biodiversitätsforschung weiteren Communities zur Verfügung. Über eine generische Archivierungsschnittstelle werden die Daten in einem Digitalen Langzeitarchiv ingestiert und können in ausgewählten Fachportalen publiziert werden.
Magazine für audiovisuelle Medien in Bau 3 des Staatsarchivs Zürich: Spezifizierung, Realisierung und Inbetriebnahme
Authors: Padeste Romano 
Published: November 2023

Zusammenfassung
Dieser Artikel beschreibt den Prozess vom ersten Konzept über die Realisierung bis hin zur Inbetriebnahme der Magazine für audiovisuelle Medien in Bau 3 des Staatsarchivs Zürich. Er beleuchtet dabei die vielseitigen Vorbereitungsarbeiten, einschließlich der Durchführung von Akklimatisierungstests, die auf diesem Weg Grundvoraussetzungen für eine erfolgreiche Umsetzung des Konzepts darstellten. Er erläutert zudem den Einfluss der Digitalisierungsstrategie auf die Lagerung der audiovisuellen Quellen.
Synthetic data generation for the continuous development and testing of autonomous construction machinery
Authors: Schuster Alexander , Hagmanns Raphael , Sonji Iman , Löcklin Andreas , Petereit Janko , Ebert Christof , Weyrich Michael 
Published: November 2023

Abstract
The development and testing of autonomous systems require sufficient meaningful data. However, generating suitable scenario data is a challenging task. In particular, it raises the question of how to narrow down what kind of data should be considered meaningful. Autonomous systems are characterized by their ability to cope with uncertain situations, i.e. complex and unknown environmental conditions. Due to this openness, the definition of training and test scenarios cannot be easily specified. Not all relevant influences can be sufficiently specified with requirements in advance, especially for unknown scenarios and corner cases, and therefore the “right” data, balancing quality and efficiency, is hard to generate. This article discusses the challenges of automated generation of 3D scenario data. We present a training and testing loop that provides a way to generate synthetic camera and Lidar data using 3D simulated environments. Those can be automatically varied and modified to support a closed-loop system for deriving and generating datasets that can be used for continuous development and testing of autonomous systems.
Die Bibliotheken im Bayerischen Wald
Authors: Kožíšek Ouřadová Martina 
Published: November 2023

Abstract
Die tschechische Bibliothekarin absolvierte einen Fachaufenthalt in sieben bayerischen Bibliotheken im Rahmen des Stipendienprogramms „Librarian in Residence“ (BII). Der Schwerpunkt lag auf Bibliotheken in kleineren Städten und Dörfern nahe der tschechisch-deutschen Grenze. In persönlichen Gesprächen lernte Martina Kožíšek Ouřadová die Besonderheiten der Arbeit in den Bibliotheken kennen, suchte nach Gemeinsamkeiten und dachte über Möglichkeiten der Zusammenarbeit nach, die sich aus einer Reihe gemeinsamer Themen und einer engen Distanz ergeben.
Der Digital Turn in den Geisteswissenschaften und seine Implikationen für Gedächtniseinrichtungen
Authors: Donig Simon 
Published: November 2023

Zusammenfassung
Der digitale Wandel hat in den letzten Jahrzehnten die Geisteswissenschaften transformiert. Jede Art von Tätigkeit in Forschung und Lehre hat zumindest einen digitalen Anteil und sei es, dass dieser nur in der Nutzung digitaler Informationsinfrastrukturen für die Recherche besteht. In den historisch arbeitenden Wissenschaften mag der Beharrungswille größer sein als in anderen Disziplinen, aber auch hier haben sich in den vergangenen Jahren zwei Tendenzen herauskristallisiert: Erstens nimmt die Arbeit mit digitalen Surrogaten analoger Quellen zu – und wird noch mehr an Bedeutung gewinnen, je mehr die Fächer mit digital geborenen Quellen arbeiten. Zweitens werden die historischen Fächer selbst zu Produzenten von Forschungsdaten. Der Beitrag zeichnet diese Veränderungen nach und zeigt exemplarisch aktuelle Verfahren, Workflows und deren Voraussetzungen. Für die Gedächtniseinrichtungen argumentiert er, dass diese die sich abzeichnende Entwicklung nicht nur nicht ignorieren dürfen, sondern dass sie bereits jetzt ein wichtiger Teil des digitalen Umbruchs sind, der sich durch eine Konvergenz von Datenkompetenzen, aber auch von Verfahren und Modellierungen über die Grenzen der Fächer hinweg auszeichnet. Abschließend reflektiert der Beitrag, auf welche Weise Gedächtniseinrichtungen den Anforderungen dieser Veränderung und neuer Gruppen von Nutzenden gerecht werden können und welche Herausforderungen auch epistemischer Art in den bestehenden Sammlungen ruhen.