bluuebunny/crossref_metadata_2025_split huggingface dataset:
Olaparib increases chemosensitivity by upregulating miR-125a-3p in ovarian cancer cells
Authors: Wang Zehua , Pu Tao , Gao Yi , Gao Jianwen , Xu Congjian 
Published: October 2023

Abstract
Objective
Ovarian cancer has the highest mortality rate among malignant gynecological tumors. PolyADP-ribose polymerase (PARP) inhibitor maintenance therapy is the standard treatment. Olaparib is a widely used oral PARP inhibitor for tumors with BRCA mutations, but its effect and molecular mechanism in non-BRCA-mutated tumors remain unclear.
Methods
The antitumor effect of cisplatin alone or in combination with olaparib was analyzed in an ovarian cancer subcutaneous transplantation tumor model in nude mice. miRNA expression was analyzed through an miRNA array and real-time PCR. The effect of miR-125a-3p on proliferation in non-BRCA-mutated A2780 and OVCAR-3 ovarian cancer cells was detected with cell counting kit-8. Changes in cell invasion and migration ability were detected via cell scratch assays and Transwell assays. β-Galactosidase (SA-β-Gal) was used to detect expression changes related to cellular senescence. Cell cycle changes were detected by flow cytometry, and the expression of DNA damage repair proteins was detected by western blotting.
Results
In vivo, cisplatin plus olaparib significantly reduced tumor volume in mice subjected to subcutaneous tumor transplantation (A2780 and OVCAR-3 cells) (p < 0.01) and inhibited tumor growth. Additionally, olaparib induced senescence in A2780 and OVCAR-3 cells by upregulating miRNA-125a-3p. miRNA-125a-3p overexpression significantly inhibited invasion and migration in A2780 and OVCAR-3 cells. The cell cycle was blocked in G0/G1 phase, and the expression of the DNA damage protein gamma-H2AX (γ-H2AX) increased. Transfection of miRNA-125a-3p inhibitors reversed these phenotypes.
Conclusions
Olaparib induces DNA damage and senescence in ovarian cancer cells by upregulating miR-125a-3p expression, improving therapeutic sensitivity.
Efficacy of fentanyl combined with bupivacaine and morphine for cesarean section -- A double-blinded randomized controlled trial
Authors: Li Gehui , Zeng Fanfang , Qi Xiaofei , Tan Xuhong , Wang Hao , Huang Xiaolei , Li Yuantao , Xia Yun 
Published: October 2023

Abstract
Adequate anesthesia is necessary during the cesarean delivery. We studied the anesthesia efficacy and safety of different doses of fentanyl combined with 10 mg bupivacaine and 0.1 mg morphine for elective cesarean section. We performed a double-blinded, randomized, and controlled trial in pregnant women undergoing elective cesarean delivery between April 2019 and June 2021. Eligible women were randomized into groups C, F1, F2, F3, F4, or F5 based on different doses of fentanyl (0, 5, 10, 15, 20, or 25 µg, respectively) during the spinal anesthesia. Each woman also received 0.1 mg morphine and 10 mg bupivacaine. Sensory and motor blocks, muscle relaxation, pain intensity, intraoperative hemodynamics (every 5 min from the intrathecal injection), and adverse events were recorded and compared. Our study included a total of 180 women, with 30 women in each group. Compared with group C, group F2–5 had a faster onset of sensory block (P < 0.001) and group F1–5 had a faster onset of motor block (P = 0.015). During the surgery, diastolic blood pressures in groups F4 and F5 were lower than those in group C between 5 and 20 min after the anesthesia initiation (P < 0.05). Heart rate in group F5 was significantly higher than those in group C at 5 and 15 min after the anesthesia initiation (P = 0.016 and 0.008), respectively. Group F4 and F5 required a higher dose of phenylephrine to prevent hypotension than group C (P = 0.027). There was no significant difference in muscle relaxation, postoperative analgesia, and adverse events among these groups. Intrathecal fentanyl administration at the doses of 10–15µg combined with 10 mg bupivacaine and 0.1 mg morphine could provide rapid and satisfactory analgesia without additional adverse events during elective cesarean delivery.
Geochemical evaluation and the mechanism controlling groundwater chemistry using chemometric approach and groundwater pollution index (GPI) in the Kishangarh city of Rajasthan
Authors: Kumar Manish , Garg Vipin , Kumar Ramesh , Kumar Rajesh 
Published: October 2023

Abstract

Globally, groundwater is a precious natural asset, serving as a dependable source for irrigation and drinking water requirements. This study is primarily focused on delving into the geochemistry of groundwater in the Kishangarh area, located in the Ajmer district of Rajasthan. In pursuit of this goal, the research is divided into three parts within the Kishangarh region: Badgaon Rural (KSGR), Kishangarh Urban (KSGU), and the Kishangarh RIICO marble industrial area (KSGI). Various analytical methods have been executed to assess the suitability of groundwater for various purposes based on pH, electric conductivity, total dissolved solids, hardness, salinity, major anions, and cations. The ionic trend of anions and cations was found as HCO3− >Cl−>SO42−>NO3−>Br−> NO2−>F− and Na+>Ca2+>Mg2+>K+, respectively. Applying statistical techniques such as Principal Component Analysis (PCA) and Pearson Correlation Matrix Analysis (PCMA) makes it evident that the physicochemical attributes of water sourced from the aquifers in the study area result from a blend of diverse origins. In addition, Gibbs, Piper, Durov, and scatter plots assessed groundwater's geochemical evolution. The scatter plots have evaluated the impression of mine acid leachate, evaporitic dissolution, and silicate weathering to upsurge salt formation in the groundwater. The pollution risk evaluation within the study area was conducted using the Groundwater Pollution Index (GPI). This index revealed a notable concern for pollution, particularly in the northern segment of the study region. As a result, it can be inferred that the fine aeolian sand and silt formations in the northern part are relatively more vulnerable to contamination.
A retrospective longitudinal assessment of artificial intelligence- assisted radiographic prediction of lower third molar eruption
Authors: Chopra Shivi , Vranckx Myrthel , Ockerman Anna , Östgren Peter , Krüger-Weiner Carina , Benchimol Daniel , Shujaat Sohaib , Jacobs Reinhilde 
Published: October 2023

Abstract
Prediction of lower third molar eruption is crucial for its timely extraction. Therefore, the primary aim of this study was to investigate the prediction of lower third molar eruption and its uprighting with the assistance of an artificial intelligence (AI) tool. The secondary aim was identifying the incidence of fully erupted lower third molars with hygienic cleansability. In total, 771 patients having two panoramic radiographs were recruited, where the first radiograph was acquired at 8–15 years of age (T1) and the second acquisition was between 16–23 years (T2). The predictive model for third molar eruption could not be obtained as few teeth reached full eruption. However, uprighting model at T2 showed that in cases with sufficient retromolar space, an initial angulation of < 32° predicted uprighting. Full eruption was observed for 13.9% of the teeth, and only 1.7% showed hygienic cleansability. The predictions model of third molar uprighting could act as a valuable aid for guiding a clinician with the decision-making process of extracting third molars which fail to erupt in an upright fashion. In addition, a low incidence of fully erupted molars with hygienic cleansability suggest that a clinician might opt for prophylactic extraction.
Endovascular Intravascular Intervention for Central Venous Stenosis in Maintenance Hemodialysis Patients: a Retrospective Observational Study
Authors: Tao Yiming , Wang Jianyun , Ma Jianchao , Peng Siqi , Chen Boxi , Deng Shuting , Yuan Ye , Jiang Nan , Wen Sichun , Li Bohou , Wu Qiong , Xu Lixia , Li Sijia , Lin Ting , Wen Feng , Fu Lei , Li Zhuo , Huang Renwei , He Chaosheng , Wang Wenjian , Ye Zhiming , Feng Zhonglin , Shi Wei , Liu Shuangxin 
Published: October 2023

Abstract
Background
The number of people undergoing maintenance hemodialysis is increasing rapidly worldwide. Owing to the widespread use of temporary catheterization, central vein stenosis (CVS) is a common vascular complication in patients undergoing hemodialysis. This study aimed to investigate the characteristics of CVS and the clinical effectiveness of percutaneous transluminal angioplasty (PTA) alone and sequential percutaneous transluminal stenting (PTS) in hemodialysis patients with CVS.
Methods
A retrospective analysis of 26 cases of endovascular intervention for CVS using PTA alone or sequential PTS was performed. The characteristics of CVS and the clinical effectiveness of these procedures were evaluated.
Results
This study included 26 hemodialysis patients who presented with symptomatic CVS. Of these 26 patients, 53.85% were male, and their mean age was approximately 54.96 years. All the patients had a history of catheter placement or pacemaker implantation. The incidence of brachiocephalic vein stenosis was significantly higher than that of subclavian vein stenosis (46.16% vs. 26.92%). Based on the degree of stenosis and elastic retraction, these patients were administered PTA alone or sequential PTS. There was no difference in patient age, hemodialysis time, catheter retention time, or stenosis length between the PTA alone and sequential PTS groups. However, the degree of venous stenosis in the PTS group was more severe than that in the PTA alone group. The primary patency rates in the sequential PTS and PTA alone groups were 94.12% and 100% at 3 months; 88.24% and 88.89% at 6 months; 75.00% and 85.71% at 9 months; and 66.67% and 71.43% at 12 months, respectively. The patency rate of the PTA alone group with central venous elastic retraction of < 50% was consistent with the patency rate of the sequential PTS group with central venous elastic retraction of ≥ 50%. It is worth noting that for 7 patients with complete occlusion of the brachiocephalic vein, we used sharp recanalization technology and stenting placement, with patency rates of 85.71% and 71.43% at 6 and 12 months, respectively.
Conclusions
PTA alone is recommended for patients with less than 50% central venous elastic retraction, while sequential PTS is recommended for patients with ≥ 50% central venous elastic retraction. PTA and PTS are safe and effective methods for the treatment of CVS in patients undergoing hemodialysis.
Causal effects of general anaesthesia and type 2 diabetes: a Mendelian randomization study
Authors: Liu GuangHeng , Zhang Jing , Hou NianGuo 
Published: October 2023

Abstract

Background
Previous studies have shown that perioperative patients would experience an increase in blood glucose levels due to the administration of multiple medicines. Some animal studies indicated the relationship between intravenous anaesthetic and insulin resistance. However, there is a lack of further research on the relationship between anaesthesia and type 2 diabetes mellitus (T2DM). This study aims to investigate the potential causal effects between general anaesthesia and T2DM using Mendelian randomization(MR) method.
Methods
We obtained public available genome-wide association study (GWAS) summary statistics of general anaesthesia from the Medical Research Council-integrative Epidemiology Unit (MRC-IEU) consortium. GWAS data for type 2 diabetes were obtained from a meta-analysis of GWAS of European ancestry. General anaesthesia includes inhalation anaesthetic using muscle relaxant; inhalation anaesthetic using endotracheal intubation; inhalation anaesthetic; intravenous anaesthetic; other specified general anaesthetic; and unspecified general anaesthetic. Five MR methods including the inverse-variance weighted (IVW), weighted median, MR-Egger, Simple mode, and Weighted mode were used to test the causal relationship.
Results
The results of MR showed that both inhalation anaesthesia using endotracheal intubation (mean ± se: 6.05 ± 2.80, p < 0.05) and intravenous anaesthesia (22.19 ± 6.52, p < 0.001) would increase the risk of T2DM. The other general anaesthesia methods have no causal effect on the risk of T2DM.
Conclusion
This MR study supports that both inhalation anaesthesia using endotracheal and intravenous anaesthesia would increase the risk of T2DM. The result is consistent with previous researches. Further research on the underlying mechanisms should be carried out to evaluate the value of this result for the high-risk population of T2DM who need anaesthesia surgery.
Investigation of structural and optical Characteristics of Cerium-Doped Silicon-Rich Nitride thin films Deposited by plasma-enhanced chemical vapor deposition
Authors: BEKHEDDA Kheira , TIOUR Faiza , MEFOUED Amine , MENARI Hamid , BOUDEFFAR Fatima , ACHOUR Wafaa 
Published: October 2023

Abstract
In this work, the silicon nanostructures were formed on silicon-rich silicon nitride (SRSN) by plasma-enhanced chemical vapor deposition methods at low temperature Then, it was doped with Cerium (Ce) via a facile evaporation technique. Furthermore, the annealing temperature was varied in order to investigate its effective role in incorporating and activating rare earth ions in the SiNx matrix.
The structural, morphological, and optical characteristics of the films were evaluated by Raman spectroscopy at room temperature, scanning electron microscopy (SEM), energy dispersive X-ray (EDS), photoluminescence spectroscopy and UV-Vis transmittance spectroscopy, respectively. SEM images demonstrated a good Ce3+ integration into silicon nitride, as well as great transparency in the visible region and outstanding UV absorption. The deposited thin films band gap was estimated to be in the range of 2.43-1.15 eV. Hence, the addition of Cerium (Ce) boosted the UV absorption of the films. Therefore, SiNx thin films as a function of Ce doping are promising candidates for photovoltaic application. moreover, a new silicon nitride compound was produced to promote research into new industrial materials. From an industrial standpoint, the development of novel inexpensive and controllable approaches based on silicon nitride phosphors should be expanded.
Haplotype analysis at HTT locus in Huntington’s disease patients from India
Authors: Purushottam Meera , Venkatesh Sowmya , Ganesh Akshaya , Viswanath Biju , Holla Vikram , Kamble Nitish , Yadav Ravi , Varghese Mathew , Pal Pramod , Jain Sanjeev 
Published: October 2023

Abstract
Huntington's disease (HD) is caused by an increase in the number of CAG triplet repeats in exon 1 of the Huntingtin (HTT) gene. Expansions that contain more than 39 repeats predispose to disease. Some specific genetic elements (SNPs), and the haplotypes they create (haplogroups A, B, and C), located at the HTT locus seem to impact CAG repeat instability, and thus the prevalence of disease across different ethnic groups. We describe the haplotype structure in HD patients from India, using previously described informative SNPs at the HTT locus. We found that 27.8% of the HD patients are associated with high-risk haplotype variants (A1 and A2) and identified new variants within haplogroup A2 and C in HD patients. However, the representative control populations (1000 Genome South Asian and Genome Asia India) showed a complete absence of haplogroup A1. The major haplogroup in both HD and control populations was A4. The distribution of haplogroups A, B, and C among Indian HD patients suggested a mixture of genetic influences from European, East Asian and African populations. Also, a new variant of Hap.15 was identified in the Hap.01-Hap.16 haplotype classification. Additionally, we propose a new haplotype classification specifically for HD patients in India. The novel HTT haplotypes (HT-1 to HT-7) classification exhibited significant heterogeneity in HD patients. The observed variation may be attributed to population heterogeneity or multiple ancestral origins.
Effect of alkyl-silane-modified supplementary cementitious materials on the workability, hydration, and strength of ultra-high-performance concrete
Authors: Zhang Yisheng , Li Yihang , Xiao Lutong , Lou Guanghui , Zou Dinghua 
Published: October 2023

Abstract
Two alkyl silanes, namely propyltriethoxysilane (PTOS) and triethoxyoctylsilane (TTOS), were used to modify the surfaces of supplementary cementitious materials (SCMs) such as silica fume and fly ash to enhance the workability of ultra-high-performance concrete (UHPC). The results showed a significant improvement in the workability of UHPC with saline modified SCMs. The hydrophobicity of the silanes inhibited the pozzolanic reaction of the SCMs after 1 day and 3 days, reducing the compressive and flexural strengths of the UHPC. However, PTOS accelerated the hydration after 3 days, which led to an improvement in the strength of UHPC. After 28 days, the UHPC containing PTOS-modified SCMs had a strength equivalent to, or slightly lower than, that of plain concrete. In contrast, TTOS had a greater hydrophobicity than PTOS, resulting in an increased inhibitory effect. Hence, the UHPC containing TTOS-modified SCMs had fewer hydration products, resulting in lower strength after 28 days.
From Kitchen Garden to Multifunctionality: Leek-inspired Surface Structures Introduce Optical and Self-cleaning Properties to Cellulose-based Films
Authors: Vapaavuori Jaana , Shirazi Hamidreza Daghigh , Mirmohammadi Seyed Mehran , Mousavi Seyede Maryam , Markkanen Magnus , Halme Janne , Jokinen Ville 
Published: October 2023

Abstract

A bioinspired approach to produce all-biobased films with high anisotropic light scattering and superhydrophobicity is presented as a route toward sustainable light management layers for photovoltaics. The multifunctional films are achieved by replicating leek leaves onto cellulose acetate, producing hierarchical surface structures. The free-standing films show a transmittance of ≈ 94% and a haze of ≈ 54% at the wavelength of 550 nm. Inspired by leek’s epicuticular wax, surface hydrophobicity was achieved through tailoring carnauba wax coatings. The surfaces show anisotropic advancing contact angles of up to 160° and 156° in cross directions, due to the periodical surface roughness and low-surface-energy carnauba wax secondary features. Using the replica as the light management layer on perovskite solar cells improved the power conversion efficiency by 6 ± 0.3%. Meanwhile, the surface water repellency facilitates self-cleaning, which tackles dirt accumulation, ensures maximum incident light, and maintains photovoltaic performance over time. Hence the developed films are suitable candidates as organic light management layers for improving the lifetime and efficiency of solar cells and other optoelectronics. Furthermore, the method can be potentially employed to fabricate substrates from virtually any leaf or patterned surface as the initial replication template.
Non-revenue water new paradigm for planning and management by performance indicators
Authors: AbuEltayef Hatem Taha , Alastal Khalil , AbuAlhin Khaldoun 
Published: October 2023

Abstract
Water service providers often face challenges when assessing their Non-Revenue Water (NRW) performance, which prompts them to set ambitious targets and adjust their NRW management plans. NRW planning and management involves a comprehensive approach that incorporating technical, managerial, and behavioral strategies. Insufficient NRW reduction efforts globally can be attributed to a lack of understanding the magnitude, origins, and expenses associated with NRW. Water decision-makers and staff often lack the capacity to identify the underlying causes of NRW. To address this, a new approach called the Planning and Management by Performance Indicators (PMPI) model has been developed, with a focus on reducing NRW. The PMPI model provides with a standardized and quantifiable way to evaluate NRW management performance. Comparing indicators over time, utilities can assess the effectiveness of their interventions, identify trends, and make necessary adjustments. A systematic literature review and expert consultations were conducted to develop this methodology. The ultimate goal of the study is to create a new PMPI tool for analyzing, planning, managing, implementing, and monitoring NRW. The conceptual model for PMPI of NRW was evaluated by academics and professional experts, resulting in an overall assessment of 80.0 percent. The majority of aspects were found to be well and highly validated. The PMPI approach adopts a linear sequential process, involving extensive performance indicators analysis, setting targets, creating action plans, and making continuous adjustments based on monitoring and feedback from stakeholders. To ensure a comprehensive and effective NRW approach, the model incorporates the IWA water balance dimensions and main components.
Left Atrial Thrombus Formation after Discontinuation of Anticoagulation in Patient with Severe Bioprosthetic Mitral Stenosis
Authors: King Ryan , Mathew Tobin , Whang Stella , Premyodhin Ned , Patel Pranav 
Published: October 2023

Abstract
Background: Mitral valve stenosis can be a highly symptomatic condition with significant complications if left untreated. In such cases, mitral valve replacement with a bioprosthetic or mechanical valve may be a viable solution to prevent progressive disease. Current guidelines do not recommend continued anticoagulation beyond six months for patients who have undergone bioprosthetic valve replacement without a separate indication for anticoagulation. With this case discussion we aim to 1) Review the current indications for anticoagulation for bioprosthetic mitral valves in patients without atrialfibrillation and 2) Discuss the constellation of comorbidities that may affect the decision to begin anticoagulation therapy.
Case presentation: We present a case describing a 55-year-old male with end-stage renal disease, coronary artery disease with coronary artery bypass graft surgery, and bioprosthetic mitral valve replacement two years prior with rapid degeneration of the replaced valve and on warfarin without a clear indication for anticoagulation. The patient was admitted for symptomatic, severe mitral stenosis and consideration of transcatheter mitral valve-in-valve replacement. During hospital admission, warfarin was discontinued and replaced with prophylactic anticoagulation. However, eight days after warfarin cessation an intraoperative transesophageal echocardiogram revealed a newly developed large left atrial thrombus leading to cancellation of the planned operation.
Conclusions:
This patient developed a left atrial thrombus after discontinuing warfarin in the setting of rapidly deteriorating bioprosthetic valve stenosis and vascular comorbidities. The decision to discontinue warfarin was made in concordance with current guidelines, which do not indicate systemic anticoagulation post 3-6 months after bioprosthetic valve replacement without separate indication for anticoagulation. This case identifies the need to investigate rebound hypercoagulability and further risk stratify comorbidities which may independently increase the risk of clot formation in the setting of severe mitral valve stenosis.