bluuebunny/crossref_metadata_2025_split huggingface dataset:
CO2laser therapy for management of stress urinary incontinence in women: a systematic review and meta-analysis
Authors: Hafidh Bandr , Baradwan Saeed , Latifah Hassan M. , Gari Abdulrahim , Sabban Hussein , Abduljabbar Hanin Hassan , Tawfiq Afaf , Hakeem Ghaidaa Farouk , Alkaff Alya , Alzawawi Nabigah , Iskandarani Radiah , Khurshid Kausar , Syed Kausar Aisha , Alkhiary Ammar Y. , Bukhari Ibtihal Abdulaziz , Baalharith Maha Al , Abu-Zaid Ahmed 
Published: November 2023

Background:Carbon dioxide (CO2) laser therapy is an emerging treatment for women with stress urinary incontinence (SUI).Objectives:To examine the efficacy of CO2laser therapy for management of SUI-related symptoms in women.Design:A systematic review and meta-analysis of randomized controlled trials and cohort studies.Data sources and methods:Four databases were screened until January 2023. All efficacy continuous endpoints were assessed via subtraction of the posttreatment from pretreatment values. The data were summarized as mean difference (MD) with 95% confidence interval (CI) using the random-effects model.Results:A total of 15 studies with 700 patients were analyzed. CO2laser therapy significantly decreased the 1-h pad weights at 3 months [ n = 5 studies, MD = −3.656 g, 95% CI (−5.198, −2.113), p < 0.001], 6 months [ n = 6 studies, MD = −6.583 g, 95% CI (−11.158, −2.008), p = 0.005], and 12 months [ n = 6 studies, MD = −3.726 g, 95% CI (−6.347, −1.106), p = 0.005]. Moreover, CO2laser therapy significantly decreased the International Consultation of Incontinence Questionnaire-Urinary Incontinence Short Form Scores at 3 months [ n = 10 studies, MD = −4.805, 95% CI (−5.985, −3.626), p < 0.001] and 12-months [ n = 6 studies, MD = −3.726, 95% CI (−6.347, −1.106), p = 0.005]. Additionally, CO2laser therapy significantly decreased the Pelvic Floor Impact Questionnaire scores at 6 months [ n = 2 studies, MD = −11.268, 95% CI (−18.671, −3.865), p = 0.002] and 12 months [ n = 2 studies, MD = −10.624, 95% CI (−18.145, −3.103), p = 0.006]. Besides, CO2laser therapy significantly decreased the Urogenital Distress Inventory-6 scores at 3 months [ n = 2 studies, MD = −21.997, 95% CI (−32.294, −11.699), p < 0.001], but not at 6 months [ n = 3 studies, MD = −3.034, 95% CI (−7.357, 1.259), p = 0.169]. Lastly, CO2laser therapy significantly increased the Vaginal Health Index Score at 6 months [ n = 2 studies, MD = 2.826, 95% CI (0.013, 5.638), p = 0.047] and 12 months [MD = 1.553, 95% CI (0.173, 2.934), p = 0.027].Conclusion:CO2laser therapy improved the SUI-related symptoms in women. To obtain solid conclusions, future studies should be well-designed with standardized settings, consistent therapeutic protocols, and long-term follow-up periods.
Cardiovascular Safety of the COVID-19 Vaccine in Team USA Athletes
Authors: Shah Ankit B. , Rizzo Samantha M. , Finnoff Jonathan T. , Baggish Aaron L. , Adams William M. 
Published: November 2023

Background: Despite reassuring scientific data, the lay press and social media continue to propagate largely unsubstantiated claims that a significant number of athletes have died from cardiovascular complications related to COVID-19 vaccines. The present study sought to determine the incidence of COVID-19 vaccine cardiovascular complications in Team USA athletes. Hypothesis: It was predicted that there would be a low incidence of cardiovascular complications from COVID-19 vaccination in Team USA athletes. Study Design: Descriptive epidemiology study. Level of Evidence: Level 4. Methods: A retrospective review was conducted on the United States Olympic and Paralympic Committee electronic medical record, inclusive of athletes who represented Team USA in the 2020 Tokyo and 2022 Beijing Olympic and Paralympic Games, for COVID-19 vaccine cardiac complications including sudden cardiac arrest/death, myocarditis, pericarditis, and myopericarditis. Vaccination status (ie, fully vaccinated, yes or no), date of vaccination and eligible boosters, and type of vaccination during the study period were abstracted from the electronic medical record. Results: A total of 1229 athletes represented Team USA during the 2020 Tokyo (Olympic, 697; Paralympic, 237) and 2022 Beijing Games (Olympic, 229; Paralympic, 66). For the 2020 Tokyo Games, 73.8% of Olympians and 80.6% of Paralympians with available vaccination status had completed a primary vaccine series. For the 2022 Beijing Games, 100% of Olympians and Paralympians with available vaccination status were fully vaccinated. No athletes suffered sudden cardiac arrest/death or were diagnosed with myocarditis, pericarditis, or myopericarditis after COVID-19 vaccination. Conclusion: The data demonstrate an overall willingness of elite athletes to receive recommended COVID-19 vaccination coupled with a complete absence of vaccine-related cardiac complications in >1 year of follow-up. Clinical Relevance: Supposedly, this is the first study to investigate the incidence of COVID-19 vaccine cardiovascular complications in elite athletes. These data are an important first step to better inform cardiologists and sports medicine physicians who care for elite athletes.
Does an Increase in Supraspinatus Tendon Thickness After Swimming Increase the Likelihood of Future Shoulder Pain?
Authors: Porter Kirsten , Shield Anthony , Pascoe Deborah , Harvey Jack , Talpey Scott 
Published: November 2023

Background Increase in supraspinatus tendon thickness (STT) resulting from swimming practice has been observed in those with a history of shoulder pain. The magnitude of change in STT after a swimming session and its rate of recovery may be an indicator of future shoulder pain incidence. Hypothesis The supraspinatus tendons that demonstrate a greater increase in thickness as a result of swimming practice will have an increased likelihood of future shoulder pain in a cohort of competitive swimmers over a period of 6 months. Design Descriptive epidemiology study. Level of Evidence: Level 2b, individual cohort studies. Methods: A cohort of 50 nationally qualified swimmers aged between 14 and 22 years, from 3 open National Swimming Programs in Victoria, Australia, were recruited for this study. Ultrasonographic measurements of swimmers’ STT was obtained of both shoulders, before, immediately after, and 6 hours after a single swimming practice session. Data were recorded of any significant interfering shoulder pain at 3 and 6 months after the initial testing session. Results Stepwise logistic regression models indicated that significant predictors of the likelihood of experiencing significant interfering pain were sex [significant at 6 months; odds ratio (OR) 4.2] and the extent of change in STT immediately (OR 2.3 and 1.3 per mm at 3 and 6 months, respectively) and 6 hours postpractice (OR 1.9 and 1.5 per mm at 3 and 6 months, respectively). Conclusion The current data suggest larger increases in tendon thickness after training are associated with an increased likelihood of future shoulder pain. Clinical Relevance These data may be valuable for monitoring training load and identifying athletes who may have an increased likelihood of shoulder pain.
Large Variations in Resistance to Degradation between Hyaluronic Acid Viscosupplements: A Comparative Rheological Study
Authors: Darsy Guillaume , Patarin Jeremy , Conrozier Thierry 
Published: November 2023

Intra-articular injections of hyaluronic acid (HA) are widely used in the treatment of osteoarthritis. HA half-life varies between products which might explain differences in effectiveness between viscosupplements. Aim To compare the resistance to degradation of linear and cross-linked viscosupplements using a rheological model combining mechanical and oxidative stresses, mimicking what happens inside the joint following HA injection. Methods The rheological properties of 8 HAs were measured using a stress-imposed Rheometer DHR3. Strain sweeps were carried out to evaluate the rheological properties at rest from 0.001 to 3000% at a frequency of 1 Hz. The complex modulus G*, in Pa, and the phase tangent tan δ, dimensionless, in the linear viscoelastic domain (LVED) were extracted. The oxidation tests were conducted by exposing the product to H2O2 for 30 minutes. The effect of oxidation was evaluated by measuring variations of G* and tan δ, using an oscillation time sweep. Those tests were carried out at a frequency of 1 Hz and at 1% strain in the LVED. Results At rest, the different samples exhibited various viscous behaviors. During mixing process, G* decreased from −6.4% to −31.3%. G* of low-molecular-weight HAs decreased more than that of medium molecular weight (MW) and cross-linked products. After oxidative stress, G* variation ranged from −10.1% to −46.3%. Cross-linked HAs and those containing mannitol resisted the best to degradation. Conclusions We showed large variations in resistance to degradation between viscosupplements. The duration of effectiveness of these products deserves to be compared in randomized clinical studies.
Men’s determinant factors on antenatal care involvement and childbirth place preference in Indonesia: An analysis of the 2012 Indonesia Demographic and Health Survey (IDHS)
Authors: Nurdin Azizah , Amaruddin Aldian Irma , Tahir Andi Mardiah , Jusuf Elizabet Catherine , Sari Mutmainnah 
Published: November 2023

Objective: This study aimed to describe the determinant factors of men’s involvement in antenatal care and childbirth place preference in Indonesia. Method: Secondary data from the 2012 Indonesia Demographic and Health Survey was used to identify factors determining men’s presence during antenatal care and childbirth place preference. All factors were analyzed utilizing bivariate and multivariate logistic regression. Result: Men living in urban areas, having a sufficient economy, having higher educational levels, and having more interaction with mass media were more likely present during the antenatal care of their wives. Men in Sulawesi and Maluku showed lower involvement in accompanying wives during antenatal care than those in Papua. In terms of delivery place preference, men in age 15–19 and 35–49 years, living in urban areas, having a more stable economy, reading newspapers or magazines as well as watching television at least once a week, and living in Java and Nusa Tenggara, were more likely having wife giving birth in healthcare facilities. Conclusions: Type of residence, economic situations, lower educational level, and fewer interactions with mass media and electronics are essential barriers to men’s involvement in wives’ antenatal care visits and childbirth place preference in Indonesia. Particular attention should be put to Sulawesi and Maluku to enforce the men and women as those islands underutilized antenatal care services and health facilities for childbirth.
Evaluating the Potential of a New Low-Profile Urinary Catheter in Preventing Catheter-Associated Urinary Tract Infections: A Prospective Randomized Blinded Clinical Trial
Authors: Ramezani Farahnaz , Khatiban Mahnaz , Rahimbashar Farshid , Soltanian Ali Reza , Mousavi-bahar Seyed Habibollah , Elyasi Ensieh 
Published: November 2023

Aim To investigate the efficacy of a new low-profile catheter on incidence of the catheter-associated urinary tract infections (CAUTI) in comatose patients admitted to the intensive care unit. Background Catheter-induced urothelial injury is a key component in the development of urinary tract infections in catheterized patients. Methods In this prospective randomized blinded clinical trial, 80 patients requiring indwelling urinary catheterization were equally randomized to either the standard Foley catheter (control) or the low-profile catheter (experimental) group. The signs of urinary tract infection for comatose patients were considered (ie, ≥105 of colony-forming unit/milliliter of urine, hematuria, serum leukocytes, and body temperature) and recorded at baseline and on days 3 and 5 after catheterization. The analysis of covariance was applied by the SPSS-20 software at a 95% confidence level. Results An increasing proportion of patients with elevated urinary colony counts were seen in the Foley catheter group compared with the low-profile catheter group (12.5% vs 5%). However, there were no between-group differences in the urinary colony counts and body temperature after controlling for antibiotic doses and fluid intake. Patients in the low-profile catheter group had significantly lower rates of hematuria and serum leukocytes than those in the Foley catheter group. Conclusion A newly designed low-profile urinary catheter has demonstrated a trend toward reducing the incidence of CAUTI in patients with indwelling urinary catheters. Further studies with larger sample sizes and follow-up are needed to confirm the benefits.
Reverse shoulder arthroplasty in obstetric brachial plexus injury: our experience with shoulder motion analysis
Authors: Porcellini Giuseppe , Montemagno Marco , Manzini Chiara , Fiumana Gabriele , Giorgini Andrea , Micheloni Gianmario , Tarallo Luigi 
Published: November 2023

Abstract
Background
Obstetric brachial plexus injury (OBPI) is a weakening or paralysis of the upper arm caused by brachial plexus injury followed by a muscle paralysis with severe repercussions on the movement of the shoulder joint following a progressive glenohumeral joint deformity.
This case series analyzes the clinical and radiological outcomes of reverse total shoulder arthroplasty (RSA) in OBPI patients with a follow-up of 2 years.

Materials and methods
OBPI patients with secondary end-stage glenohumeral arthritis were enrolled in the study and they were treated with RSA. Patient demographics and clinical outcomes [Range of Motion (ROM), Visual Analog Scale (VAS), Oxford Shoulder Score (OSS)] were evaluated. A novel Shoulder motion analysis was carried out to investigate specific movement patterns of scapulothoracic movements in these patients. This study is a prospective cohort study.

Results
Four Patients (M: F = 1:3) were enrolled in the study, the mean age was 49.3 years (+ 2.75), the mean OSS (Oxford Shoulder Score) decreased from 48.8 (± 2.5) preoperatively to 18.30 (± 2.78), the mean VAS (Visual Analog Scale) decreased from 7.25 (± 0.5) to 1.7 (± 0.3) in the follow up (∆% relative pain reduction:− 76.5%), Shoulder ROM obtained an improvement (p < 0.05) except for abduction and external rotation. The average follow-up time was 26.3 months (+− 4.5). Shoulder motion analysis showed a complete loss of the scapular tilting above 90 degrees of flexion compared to the typical one of standard RSA with a pattern shifted towards scapular retraction (engaging trapezius and rhomboid muscles) to compensate the loss of the posterior tilting.

Conclusions
RSA in OBPI patients demonstrated a significant improvement of pain symptoms and a moderate improvement in daily activities, anyway with a more appreciable quality of life over time even if the marked hypotrophy especially of the posterior shoulder muscles showed some limits in maintaining suspension of the upper limb and a minor external rotation, with an internal rotation attitude during the movements.
Level of evidence: Level IV, Case series.
Nominal logistic regression analysis of variables determining needle visibility in ultrasound images – a full factorial cadaver study
Authors: Dinges Hanns-Christian , Hoeft Julia , Cornelius Valér Michael , Steinfeldt Thorsten , Wiesmann Thomas , Wulf Hinnerk , Schubert Ann-Kristin 
Published: November 2023

Abstract
Background
Needle visualization is essential to avoid vascular puncture and nerve injury in ultrasound-guided regional anesthesia. Several factors that statistically influence needle visibility have been described but the dimensions of their individual impact remain unclear. This study aimed to quantify the impact of various independent factors on ultrasound needle visibility.

Methods
A total of 1500 ultrasound videos of in-plane needle insertions were obtained in embalmed cadavers with ten different commercially available echogenic and non-echogenic needles at different insertion angles and bevel orientations in a full factorial study design. The visibility of needle tip and shaft were rated as “good” or “poor” visibility. Nominal logistic regression analyses were calculated for the visibility of the needle tip and shaft.

Results
SonoPlex Stim Sprotte, SonoTAP Facet (needle tip and shaft) and Spinostar PencilPoint (needle tip)), insertion angle and bevel orientation were associated with good ultrasound visibility, reaching statistical significance (p < 0.05). The range of the effect on the log-odds scale for needle tip visibility was largest for the insertion angle with 6.33, followed by the tissue condition (3.76), bevel orientation (1.45) and the needle types (1.25). Regarding the needle shaft visibility, the largest effect range was observed with the insertion angle (7.36), followed by the tissue conditions with 3.96, needle type (1.86) and bevel orientation (0.95).

Conclusion
In-plane needle visibility in ultrasound images depends mainly on the insertion angle, as expected. This is closely followed by the tissue condition, which is a factor related to the patient, thus cannot be altered to improve needle visibility. In the dimensions of the log-odds scale, the choice of a specific needle is far less important towards achieving a good visualization, whereas optimizing the bevel orientation can have a larger impact than the needle choice. Concluding from the relative dimensions of factors that determine needle visibility in this model, the importance of needles with echogenic features may be overrated.
Role of PPAR-related genes in chronic heart failure: evidence from large populations
Authors: Ke Zun-Ping , Tao Wen-Qi , Zhao Gang , Cheng Kuan 
Published: November 2023

Abstract
Background
The role of PPAR signaling and its associated genes in the pathogenesis and progression of chronic heart failure (CHF) remains elusive.

Methods
We accessed the gene expression profile and relevant baseline information of CHF samples from the Gene Expression Omnibus (GEO) database, specifically from the GSE57338 project.

Results
From GSE57338 project, we derived the expression value of 126 PPAR-related genes. A protein-protein interaction network was then established to illustrate potential protein interactions. ClueGO analysis results revealed that these genes predominantly participate in functions such as export across plasma membrane, regulation of lipid metabolic process, fatty acid metabolism, circulatory system vascular processes, alcohol metabolism, triglyceride metabolism and regulation of lipid localization and response to nutrient. Using the cytohubba plug-in in Cytoscape, we pinpointed ACADM, PPARG and CPT2 as potential central molecules in HF pathogenesis and progression. Subsequent Gene Ontology and Kyoto Encyclopedia of Genes and Genomes analysis delved into the potential biological role of these three genes in CHF. Immune infiltration analysis suggested that the infiltration level of neutrophils and M2 macrophages might be notably influenced by these genes, thereby playing a role in the CHF mechanism.

Conclusions
Our research provides a comprehensive insight into the significance of PPAR associated genes in CHF development. Notably, the genes ACADM, PPARG and CPT2 emerged as potential targets for clinical interventions.
The optimal QTc selection in patients of acute myocardial infarction with poor perioperative prognosis
Authors: Wei Xing , Feng Jun , Zhang Zhipeng , Wei Jing , Hu Ben , Long Nv , Luo Chunmiao 
Published: November 2023

Abstract
Background
The predictive utility of QTc values, calculated through various correction formulas for the incidence of postoperative major adverse cardiovascular and cerebrovascular events (MACCE) in patients experiencing acute myocardial infarction (AMI), warrants further exploration. This study endeavors to ascertain the predictive accuracy of disparate QTc values for MACCE occurrences in patients with perioperative AMI.

Methods
A retrospective cohort of three hundred fourteen AMI patients, comprising 81 instances of in-hospital MACCE and 233 controls, was assembled, with comprehensive collection of baseline demographic and clinical data. QTc values were derived employing the correction formulas of Bazett, Fridericia, Hodges, Ashman, Framingham, Schlamowitz, Dmitrienko, Rautaharju, and Sarma. Analytical methods encompassed comparative statistics, Spearman correlation analysis, binary logistic regression models, receiver operating characteristic (ROC) curves, and decision curve analysis (DCA).

Results
QTc values were significantly elevated in the MACCE cohort compared to controls (P < 0.05). Spearman’s correlation analysis between heart rate and QTc revealed a modest positive correlation for the Sarma formula (QTcBaz) (ρ = 0.46, P < 0.001). Within the multifactorial binary logistic regression, each QTc variant emerged as an independent risk factor for MACCE, with the Sarma formula-derived QTc (QTcSar) presenting the highest hazard ratio (OR = 1.025). ROC curve analysis identified QTcSar with a threshold of 446 ms as yielding the superior predictive capacity (AUC = 0.734), demonstrating a sensitivity of 60.5% and a specificity of 82.8%. DCA indicated positive net benefits for QTcSar at high-risk thresholds ranging from 0 to 0.66 and 0.71–0.96, with QTcBaz, prevalent in clinical settings, showing positive net benefits at thresholds extending to 0-0.99.

Conclusion
For perioperative AMI patients, QTcSar proves more advantageous in monitoring QTc intervals compared to alternative QT correction formulas, offering enhanced predictive prowess for subsequent MACCE incidents.
Toward sustainable development goals in gender inequality: an analysis of gender preferences among urban pregnant women in a Southeast Asian country
Authors: Nguyen Anh Duy , Nguyen Long Hoang , Nguyen Lam Duc , Ninh Ly Thi , Nguyen Ha Thu Thi , Nguyen Cuong Tat , Nathan Nila , Do Anh Linh , Le Anh Minh , Doan Linh Phuong , Nguyen Son Hoang , Vu Thuc Minh Thi , Tran Bach Xuan , Latkin Carl A. , Ho Cyrus S.H. , Ho Roger C.M. 
Published: November 2023

AbstractBackgroundGender-biased discrimination and preferences are global phenomena, particularly son preferences. However, updated evidence about this issue in Vietnam has not yet been provided. Therefore, this study aimed to examine the gender preferences among pregnant women and identify associated factors of such preferences.MethodsA cross-sectional survey was conducted in two hospitals in Vietnam with 732 pregnant women. Gender preferences for their child were asked, along with socio-demographic (e.g., education, occupation) and pregnancy characteristics (e.g., pressure to have a son, gender of first child, the importance to have a son of family members, and information sources on pregnancy care) by using face-to-face interviews and a structured questionnaire. Multinomial logistic regression was performed to determine factors associated with gender preferences.ResultsAbout 51.9% of the participants had no gender preference, while, among those who had a gender preference, 26.5% preferred sons, and 21.6% preferred daughters. Only 6.2% had pressure to have a son. Having the first child who was female (OR = 4.16, 95%CI = 1.54–11.25), having the pressure to have a son (OR = 6.77, 95%CI = 2.06–22.26), and higher self-perceived importance to have a son (OR = 3.05, 95%CI = 1.85–5.02) were positively associated with son preference. Otherwise, women having partners with high school education or above (OR = 2.04, 95%CI = 1.06–3.91), living with parents-in-law (OR = 2.33; 95%CI = 1.25–4.34), the higher number of pregnancies, and a higher degree of importance in having a son regarding parents-in-law (OR = 2.15, 95%CI = 1.38–3.35) associated with higher odds of preferring daughter.ConclusionThis study showed that gender preference was common among pregnant women, but the pressure to have a son was low. Further education programs and legal institutions should be implemented to improve gender inequality and gender preference in society.