bluuebunny/crossref_metadata_2025_split huggingface dataset:
Impact of acute kidney injury and renal recovery status in deceased donor to kidney transplant outcome: results from the Thai national transplant registry
Authors: Larpparisuth Nuttasith , Nivatvongs Supanit , Noppakun Kajohnsak , Lumpaopong Adisorn , Pongskul Cholatip , Skulratanasak Peenida 
Published: November 2023

AbstractThe influence of acute kidney injury (AKI) and renal recovery in deceased donor (DD) on long-term kidney transplant (KT) outcome has not previously been elucidated in large registry study. Our retrospective cohort study included all DDKT performed in Thailand between 2001 and 2018. Donor data was reviewed case by case. AKI was diagnosed according to the KDIGO criteria. Renal recovery was defined if DD had an improvement in AKI to the normal or lower stage. All outcomes were determined until the end of 2020. This study enrolled 4234 KT recipients from 2198 DD. The KDIGO staging of AKI was as follows: stage 1 for 710 donors (32.3%), stage 2 for 490 donors (22.3%) and stage 3 for 342 donors (15.6%). AKI was partial and complete recovery in 265 (17.2%) and 287 (18.6%) before procurement, respectively. Persistent AKI was revealed in 1906 KT of 990 (45%) DD. The ongoing AKI in DD significantly increases the risk of DGF development in the adjusted model (HR 1.69; 95% CI 1.44–1.99; p < 0.001). KT from DD with AKI and partial/complete recovery was associated with a lower risk of transplant loss (log-rank P = 0.04) and recipient mortality (log-rank P = 0.042) than ongoing AKI. KT from a donor with ongoing stage 3 AKI was associated with a higher risk of all-cause graft loss (HR 1.8; 95% CI 1.12–2.88; p = 0.02) and mortality (HR 2.19; 95% CI 1.09–4.41; p = 0.03) than stage 3 AKI with renal recovery. Persistent AKI, but not recovered AKI, significantly increases the risk of DGF. Utilizing kidneys from donors with improving AKI is generally safe. KT from donors with persistent AKI stage 3 results in a higher risk of transplant failure and recipient mortality. Therefore, meticulous pretransplant evaluation of such kidneys and intensive surveillance after KT is recommended.
Voice Discrimination in Quiet and in Background Noise by Simulated and Real Cochlear Implant Users
Authors: Levin Michal , Zaltz Yael 
Published: November 2023

Purpose:

Cochlear implant (CI) users demonstrate poor voice discrimination (VD) in quiet conditions based on the speaker's fundamental frequency (
f
o
) and formant frequencies (i.e., vocal-tract length [VTL]). Our purpose was to examine the effect of background noise at levels that allow good speech recognition thresholds (SRTs) on VD via acoustic CI simulations and CI hearing.

Method:

Forty-eight normal-hearing (NH) listeners who listened via noise-excited (
n
= 20) or sinewave (
n
= 28) vocoders and 10 prelingually deaf CI users (i.e., whose hearing loss began before language acquisition) participated in the study. First, the signal-to-noise ratio (SNR) that yields 70.7% correct SRT was assessed using an adaptive sentence-in-noise test. Next, the CI simulation listeners performed 12 adaptive VDs: six in quiet conditions, two with each cue (
f
o
, VTL,
f
o
+ VTL), and six amid speech-shaped noise. The CI participants performed six VDs: one with each cue, in quiet and amid noise. SNR at VD testing was 5 dB higher than the individual's SRT in noise (SRTn +5 dB).

Results:
Results showed the following: (a) Better VD was achieved via the noise-excited than the sinewave vocoder, with the noise-excited vocoder better mimicking CI VD; (b) background noise had a limited negative effect on VD, only for the CI simulation listeners; and (c) there was a significant association between SNR at testing and VTL VD only for the CI simulation listeners.

Conclusions:
For NH listeners who listen to CI simulations, noise that allows good SRT can nevertheless impede VD, probably because VD depends more on bottom-up sensory processing. Conversely, for prelingually deaf CI users, noise that allows good SRT hardly affects VD, suggesting that they rely strongly on bottom-up processing for both VD and speech recognition.
Clinical Supervision Postpandemic: Providing a Continuity of Care and Supervision Using Zoom in the University Clinic Setting
Authors: Bitetti Dana , Santarlas Amanda , Costello-Yacono Maureen 
Published: November 2023

Purpose:
The COVID-19 pandemic necessitated the shift to telepractice by university clinics. Supervision then occurred through Zoom or other videoconferencing platforms. Although clinics have returned to in-person services, the use of telepractice still continues as a preferred form of service delivery for many clients. However, providing both telepractice and in-person supervision in one university clinic can present many challenges. This article describes how one pro bono university clinic is resolving supervisor observation issues and space limitations by implementing a cohesive, low-cost Zoom observation system that is used with both in-person and telepractice clients.

Method:
The history of the previous observation system is provided along with the factors that necessitated the shift to the videoconferencing platform. The authors describe the configuration of the clinic rooms, the equipment needed to implement a similar observation system, and recommendations for getting started. This article also discusses the benefits and challenges of using the Zoom observation system for supervision with graduate student clinicians and their clients.

Conclusion:
The information is relevant to programs seeking to implement an effective low-cost observation system for training graduate students in a university clinic.
Device-Assisted Therapy for Lingual Function Rehabilitation: A “How To” Guide for Clinicians
Authors: Kallambettu Veena , Kaval Farah , Krekeler Brittany N. 
Published: November 2023

Purpose:
Lingual function rehabilitation is a frequently targeted area of exercise-based dysphagia treatment. This tutorial aims to provide a detailed guideline for clinicians on how to apply currently available evidence for implementation of lingual rehabilitation exercises both with and without device-assisted modalities.

Method:
We provide a detailed review of existing definitions of lingual function parameters (e.g., strength and endurance) with currently available normative values for clinical reference. Guidelines are also provided on how to use available lingual manometry (Iowa Oral Performance Instrument and Tongueometer) to aid in both assessment and treatment. With respect to determining exercise targets based on the lingual function assessment, we review the importance of leveraging principles of exercise physiology into the rehabilitation planning. Strategies for incorporating exercise physiology principles into strength and endurance training are provided along with a case example illustrating these concepts.

Conclusions:
This tutorial serves as a framework for clinical implementation of comprehensive lingual function assessment and rehabilitation. Considerations regarding barriers in access to equipment and clinical advocacy are also discussed.
MSCAReg‐Net: Multi‐scale complexity‐aware convolutional neural network for deformable image registration
Authors: Yu Hu , Zheng Qiang , Hu Fang , Ma Chaoqing , Wang Shuo , Wang Shuai 
Published: November 2023

AbstractDeep learning‐based image registration (DLIR) has been widely developed, but it remains challenging in perceiving small and large deformations. Besides, the effectiveness of the DLIR methods was also rarely validated on the downstream tasks. In the study, a multi‐scale complexity‐aware registration network (MSCAReg‐Net) was proposed by devising a complexity‐aware technique to facilitate DLIR under a single‐resolution framework. Specifically, the complexity‐aware technique devised a multi‐scale complexity‐aware module (MSCA‐Module) to perceive deformations with distinct complexities, and employed a feature calibration module (FC‐Module) and a feature aggregation module (FA‐Module) to facilitate the MSCA‐Module by generating more distinguishable deformation features. Experimental results demonstrated the superiority of the proposed MSCAReg‐Net over the existing methods in terms of registration accuracy. Besides, other than the indices of Dice similarity coefficient (DSC) and percentage of voxels with non‐positive Jacobian determinant (), a comprehensive evaluation of the registration performance was performed by applying this method on a downstream task of multi‐atlas hippocampus segmentation (MAHS). Experimental results demonstrated that this method contributed to a better hippocampus segmentation over other DLIR methods, and a comparable segmentation performance with the leading SyN method. The comprehensive assessment including DSC, , and the downstream application on MAHS demonstrated the advances of this method.
Gas rotation and dark matter halo shape in cool-core clusters of galaxies
Authors: Bartalesi T. , Ettori S. , Nipoti C. 
Published: November 2023

Aims.We study the possibility that the gas in cool-core clusters of galaxies has non-negligible rotation support, the impact of gas rotation on mass estimates from current X-ray observations, and the ability of forthcoming X-ray observatories to detect such rotation.Methods.We present three representative models of massive cool-core clusters with a rotating intracluster medium (ICM) in equilibrium in cosmologically motivated spherical, oblate, or prolate dark matter halos, represented by physical density–potential pairs. In the models, the gas follows a composite-polytropic distribution, and has rotation velocity profiles consistent with current observational constraints and similar to those found in clusters formed in cosmological simulations. We show that the models are consistent with available measurements of the ICM properties of the massive cluster population: the thermodynamic profiles, the shape of the surface brightness distribution, the hydrostatic mass bias, and the broadening of X-ray emitting lines. Using the configuration for the microcalorimeter onboard the XRISM satellite, we generated a set of mock X-ray spectra for our cluster models, which we then analyzed to make predictions about the rotation speed that will be obtained with such an instrument. We then assessed what fraction of the hydrostatic mass bias of our models could be accounted for by detecting the rotation speed with XRISM spectroscopy over the range (0.1 − 1)r500, sampled with three nonoverlapping pointings.Results.Current data leave room for rotating ICM in cool-core clusters, with peaks in the rotation speed as high as 600 km s−1. We show that such rotation, if present, will be detected with upcoming X-ray facilities such as XRISM and that 60 − 70% of the hydrostatic mass bias due to rotation can be accounted for using the line-of-sight velocity measured from X-ray spectroscopy with XRISM, with a residual bias smaller than 3% at an overdensity of 500. In this way, XRISM will allow us to pin down any mass bias of a different origin from the rotation.
Diagnosis and Therapy of Visceral Vein Thrombosis: An Update Based on the Revised AWMF S2k Guideline
Authors: Mühlberg Katja S. 
Published: November 2023

AbstractSplanchnic or visceral vein thromboses (VVTs) are atypical thrombotic entities and include thrombosis of the portal vein, hepatic veins (Budd-Chiari syndrome), mesenteric veins, and splenic vein. All VVTs have in common high 30-day mortality up to 20% and it seems to be difficult to diagnose VVT early because of their rarity and their wide spectrum of unspecific symptoms. VVTs are often associated with myeloproliferative neoplasia, thrombophilia, and liver cirrhosis. VVT is primarily diagnosed by sonography and/or computed tomography. In contrast to venous thromboembolism, D-dimer testing is neither established nor helpful. Anticoagulation is the first-line therapy in patients with stable circulation and no evidence of organ complications. Anticoagulation improves significantly recanalization rates and stops the progress of thrombosis. Low-molecular-weight heparin, vitamin K antagonists, as well as direct-acting oral anticoagulants are possible anticoagulants, but it is noteworthy to be aware that all recommendations supporting the off-label use of anticoagulants are based on poor evidence and consist predominantly of case series, observational studies, or studies with small case numbers. When choosing a suitable anticoagulation, the individual risk of bleeding and thrombosis must be weighted very carefully. In cases of bleeding, bowel infarction, or other complications, the optimal therapy should be determined on a case-by-case basis by an experienced multidisciplinary team involving a surgeon. Besides anticoagulation, there are therapeutic options including thrombectomy, balloon angioplasty, stenting, transjugular placement of an intrahepatic portosystemic shunt, liver transplantation, and ischemic bowel resection. This article gives an overview of current diagnostic and therapeutic strategies.
Handchirurgie bei entzündlich rheumatischen Erkrankungen
– ein Update
Authors: Gaulke Ralph 
Published: November 2023

ZusammenfassungDie peripheren Gelenke an Händen und Füßen sind bei
entzündlich-rheumatischen Erkrankungen und hier insbesondere bei der
rheumatoiden Arthritis und bei Arthritis psoriatica sehr häufig von der
Entzündung betroffen. Neben den Gelenken sind besonders die
Entzündungen der Sehnenscheiden zu beachten, da diese unbehandelt zu
einer Durchwanderung der Sehne führen können welche dann
Defektrupturen bedingen. Die Rekonstruktion dieser langstreckig
geschädigten Sehnen ist aufwendig und die Ergebnisse sind schlechter als
die der Tenosynovialektomie. Sollte eine ansonsten wirksamer Basistherapie an
einzelnen Gelenken der Hand nicht zu einer Beruhigung der Entzündung
führen, so ist die operative Synovialektomie zum Gelenkserhalt
indiziert. Da neben den Gelenken der Hand auch häufig Destruktionen mit
Bewegungseinschränkungen am Schulter- und Ellenbogengelenk auftreten,
sollte bei Destruktionen im Handgelenk nicht generell eine komplette Arthrodese
durchgeführt werden, so lange noch Gelenkkompartimente erhalten sind. Es
bestehen zahlreiche Möglichkeiten durch karpale Teilarthrodesen die
Schmerzen zu nehmen, das Handgelenk zu stabilisieren und eine Restbeweglichkeit
zu erhalten. Für instabile und destruierte Fingergrundgelenke ist der
Swanson-Spacer weiterhin der Goldstandard. Für die Fingermittelgelenke
steht mittlerweile seit mehreren Jahren ein Oberflächenersatz zur
Verfügung, welcher eine gute Osteointegration zeigt und damit die
stielgeführten Prothesen, die in der Regel nicht einheilen oder
gehäuft zu periprothetischen Frakturen führen, abgelöst
hat. Die Operation sollte an der entzündlich-rheumatisch
veränderten Hand streng aber dennoch konsequent und ohne zeitliche
Verzögerung gestellt werden, um so viele Gelenke wie möglich zu
erhalten. Da viele Destruktionen und Fehlstellungen
entzündlich-rheumatischer Genese radiologisch posttraumatischen und
degenerativen Veränderungen ähneln, aber dennoch
unterschiedlicher chirurgischer Therapie bedürfen, sollten diese dem
orthopädischen Rheumatologen zugeführt werden, um das
bestmögliche Ergebnis zu erzielen und Folgeoperation möglichst
zu vermeiden.
The Influence of Hyperglycemia on Liver Triglyceride Deposition in
Partially Pancreatectomized Rats
Authors: Bai Xiu-Ping , Li Ting-Ting , Guo Lai-Li , Wang Jing , Dong Feng 
Published: November 2023

AbstractNonalcoholic fatty liver disease and diabetes always coexist. The relationship of
fatty liver and hyperglycemia is not clear. We studied the influence of
hyperglycemia on triglyceride (TG) accumulation in the liver and explored its
possible mechanisms. SD rats were divided into three groups: Group A (sham
operation control), Group B (partially pancreatectomized rats), and Group C
(partially pancreatectomized rats treated with insulin). At 4 weeks after
surgery, pancreatic weights and liver TG contents were measured. Serum
biochemical parameters were determined, and oral glucose tolerance tests (OGTT)
were performed. The gene expression of sterol regulatory element-binding
protein1c (SREBP-1c), carbohydrate regulatory element-binding protein (ChREBP),
fatty acid synthase(FAS), carnitine palmitoyltransferase 1 (CPT-1), and
fibroblast growth factor 21 (FGF21) was determined by real-time PCR. Compared
with Group A, postprandial glucose increased significantly; the concentrations
of insulin and C-peptides, pancreatic weights and serum FGF21 levels were
decreased, liver TG was increased significantly in Group B, and insulin
treatment improved these changes. Compared with Group A, the gene expressions of
FGF21, CPT-1 and FAS in the liver were decreased in Group B (all
p<0.05). Compared with Group B, the gene expressions of FGF21, FAS,
ChREBP, SREBP-1c and CPT-1 in the liver in Group C were all increased
significantly (p<0.05, respectively). Hyperglycemia induced by partial
pancreatectomy could lead to increased liver TG. Insulin treatment could
decrease glucose levels and improve fatty liver, and genes related to lipid
metabolism may play a role in this process.
Does Chronic Subjective Tinnitus Affect Cognitive Performance In Adults with Hearing Thresholds of 25 dB and Less Between 0.5-4 kHz
Authors: Deniz-Sakarya Merve , Çinar-Satekin Merve , Yaldız Zahide Ç.B. , Tokgoz-Yilmaz Suna 
Published: November 2023

Abstract
Background In literature, the cognitive performance results of normal hearing individuals with tinnitus are inconsistent. It also differs in the control of other factors that may affect cognition.
Purpose This study aimed to determine the differences in attention and memory performance between normal hearing individuals with chronic subjective tinnitus and age–sex–education-matched healthy controls.
Study Sample Normal hearing individuals with subjective chronic tinnitus between 18 and 55 years of age, who have normal cognitive abilities (tinnitus group, n = 30) and age–sex-matched normal hearing individuals without tinnitus who have normal cognitive abilities (control group, n = 30) were included in this study.
Data Collection The Montreal Cognitive Assessment Test measured participants' general cognitive screening, and depressive symptoms were measured by Beck Depression Inventory (BDI). Tinnitus Handicap Inventory was used to determine the tinnitus handicap levels. Attention performance was evaluated with Stroop Test-TBAG Form, and short-term and working memory performances were evaluated with the Wechsler Adult Intelligence Scale-Revised (WAIS-R)-Digit Span Test.
Results The tinnitus and control groups' depressive symptom scores were similar concerning the BDI (p = 0.90). There was no statistically significant difference between both groups according to the completion time of the five sections of the Stroop Test, the number of errors and corrections of the Stroop 5 test, and the (WAIS-R)-Digit Span Test scores (p > 0.05).
Conclusion In our study, the Stroop Test and Digit Span Test performances of individuals with tinnitus and normal hearing were similar to the control group. Despite previous studies claiming an effect of tinnitus on cognition, our contrary findings are discussed in the light of other demographic, audiological, and psychological measurement variables, especially hearing loss.
A Comprehensive Analysis of Academic Attributes of the Presidents of the North American Skull Base Society
Authors: Plute Tritan , Bin-Alamer Othman , Mallela Arka N. , Zenonos Georgios A. , Wang Eric W. , Gardner Paul A. , Couldwell William T. , Snyderman Carl H. , Abou-Al-Shaar Hussam 
Published: November 2023

Abstract
Objectives Our objective was to elucidate the demographic, academic, and career attributes of North American Skull Base Society (NASBS) presidents and determine how leadership of this society has changed over time.
Design Thirty-one NASBS presidents have served between 1990 and 2021. Demographic and scholarly variables were recorded from publicly available sources. To determine how trends in NASBS presidents have changed over time, linear and logistic regressions were conducted on continuous and categorical variables, respectively.
Setting Virtual setting was used for this study.
Participants There were no active participants in the study.
Main Outcome Measures Academic metrics of NASBS presidents were the main outcome measure.
Results NASBS presidents had a mean age of 53.3 ± 6.1 years at election and were all male. The most common institution at which former presidents trained (n = 4) and practiced (n = 3) was the University of Pittsburgh. Otolaryngologists comprised 41.9% (n = 13) of the cohort, neurosurgeons made up 38.8% (n = 12), and the remaining 19.3% (n = 6) were from other specialties. NASBS presidents from neurosurgery (p = 0.033) and other specialties (p = 0.014) were more likely to hold the rank of chair compared with those from otolaryngology. Over time, there has been a linear increase in years of research experience at the time of election (p = 0.048). There remains a lack of diversity of gender and race.
Conclusion NASBS presidents have demonstrated increased research activity over time, favoring long-term academic careers. Knowledge of these trends and attributes, which demonstrate an increase in skull base literature, growth of the NASBS, and a need for increased diversity in the field, is important for stewarding the future of the NASBS and promoting equity.
Consecutive Ireland–Claisen Enyne-Metathesis Strategy Enables Rapid Assembly of Cyclic Imine Core Cyclohexene Motif
Authors: Lee Hye Joon , Gladfelder Joshua , Zakarian Armen , Kandiyal Priya 
Published: November 2023

AbstractAn efficient strategy for rapid assembly of the complex substituted cyclohexene core that is present in several cyclic imine marine toxins is presented. Several of these toxins, including pinnatoxin A and recently discovered portimine A, have been the focus of much attention due to their fascinating biological activities. We demonstrate that the substituted cyclohexene-diene motif, which is a challenging feature to access synthetically, can be prepared through a stepwise Ireland–Claisen rearrangement/enyne metathesis procedure beginning from chiral esters. This approach enables a divergent strategy that can be implemented in syntheses of cyclic imines or derivatives thereof.