bluuebunny/crossref_metadata_2025_split huggingface dataset:
Chemical Constituents of the Deep‐sea Gammarid Shrimp‐Derived Fungus Penicillium citrinum XIA‐16
Authors: Yu Hao‐Yu , Li Yan , Zhang Meng , Zou Zheng‐Biao , Hao You‐Jia , Xie Ming‐Min , Li Li‐Sheng , Meng Da‐Li , Yang Xian‐Wen 
Published: October 2023

AbstractOne new alkaloid, (S)‐2‐acetamido‐4‐(2‐(methylamino)phenyl)‐4‐oxobutanoic acid (1), was isolated from the deep‐sea‐derived Penicillium citrinum XIA‐16, together with 25 known compounds including ten polyketones (2–11), eight alkaloids (12–19), six steroids (20–25), and a fatty acid (26). Their planar and relative structures were determined by an analysis of 1D and 2D nuclear magnetic resonance (NMR) as well as high resolution electrospray ionization mass spectroscopy (HR‐ESI‐MS) data. The absolute configuration of 1 was determined by comparison of the experimental and calculated electronic circular dichroism (ECD) spectra. Penicitrinol B (6) significantly inhibited RSL3‐induced ferroptosis (EC50=2.0 μM) by reducing lipid peroxidation and heme oxygenase 1 (HMOX1) expression. Under the concentration of 10 μM, penicitrinol A (7) was able to inhibit cuproptosis with the cell viabilities of 68.2 % compared to the negative control (copper and elesclomol) with the cell viabilities of 14.8 %.
A rare case of Burkitt's lymphoma of the breast in a 19‐year‐old male: Case report
Authors: Kato Ronald , Solomon Kibudde 
Published: October 2023

Key Clinical MessageBurkitt's lymphoma is a highly aggressive non‐Hodgkin's lymphoma that can affect various parts of the body, which include jaw, facial bones, retroperitoneum, and abdominal viscera, it is worth noting that breast involvement is extremely rare in Burkitt's lymphoma and has not been documented.AbstractBurkitt's lymphoma is a highly aggressive non‐Hodgkin's lymphoma that can affect various parts of the body including breast. This sarcoma is identified as a rapidly fatal malignant lymphoma syndrome and 50% of all malignant tumors in children. However, breast involvement has not been documented. A 19‐year‐old male presented to our emergency department with a left breast swelling for 2 months associated with drenching night sweats, weight loss and evening fevers. Physical examination revealed a mass measuring approximately 15 × 16 × 15 cm in the widest dimension, skin hyperpigmentation, no nipple discolorations, discharges, and non‐tender on palpation. Biopsy was done, and the histology report revealed sheets of monomorphic medium lymphocytes with a high mitotic rate and frequent apoptotic bodies showing a starry‐sky appearance. The immunohistochemistry report revealed positive staining for Ki‐67, CD‐20, and CD‐10 tumor markers and CD45 on flow cytometry. The patient was started on aggressive hydration, rasubricase administration, CODOX‐M/IVAC regimen 6 cycles, and G‐CSF and registered significant reduction in the size of the mass. Burkitt's lymphoma is a highly aggressive non‐Hodgkin's lymphoma that can affect various parts of the body. It commonly involves the jaw, facial bones, retroperitoneum, and abdominal viscera. The disease typically affects young patients in areas of high incidence, such as the jaw, whereas visceral involvement is more common in older patients in low‐incidence areas. It is worth noting that breast involvement is extremely rare in Burkitt's lymphoma.
Structural Optimization of Antimycobacterial Azaaurones Towards Improved Solubility and Metabolic Stability
Authors: Campaniço André , Harjivan Shrika G. , Freitas Elisabete , Serafini Marco , Gaspar M. Manuela , Capela Rita , Gomes Pedro , Jordaan Audrey , Madureira Ana M. , André Vânia , Silva Andreia B. , Duarte M. Teresa , Portugal Isabel , Perdigão João , Moreira Rui , Warner Digby F. , Lopes Francisca 
Published: October 2023

AbstractWhile N‐acetyl azaaurones have already been disclosed for their potential against tuberculosis (TB), their low metabolic stability remains an unaddressed liability. We now report a study designed to improve the metabolic stability and solubility of the azaaurone scaffold and to identify the structural requirements for antimycobacterial activity. Replacing the N‐acetyl moiety for a N‐carbamoyl group led to analogues with sub‐ and nanomolar potencies against M. tuberculosis H37Rv, as well as equipotent against drug‐susceptible and drug‐resistant M. tuberculosis isolates. The new N‐carbamoyl azaaurones exhibited improved microsomal stability, compared to their N‐acetylated counterparts, with several compounds displaying moderate to high kinetic solubility. The frequency of spontaneous resistance to azaaurones was observed to be in the range of 10−8, a value that is comparable to current TB drugs in the market. Overall, these results reveal that azaaurones are amenable to structural modifications to improve metabolic and solubility liabilities, and highlight their potential as antimycobacterial agents.
Is there silicon in flowers and what does it tell us?
Authors: Schoelynck Jonas , De Block Petra , Van Dyck Eva , Cooke Julia 
Published: October 2023

AbstractThe emergence of flowers marked an important development in plant evolution. Flowers in many species evolved to attract animal pollinators to increase fertilisation chances. In leaves, silicon (Si) discourages herbivores, for example by wearing down mouthparts. Flowers are essentially modified leaves and hence may also have the capacity to accumulate Si. If Si in flowers discourages animal visitors as it does in leaves, Si accumulation may be disadvantageous for pollination. Whether flowers accumulate Si, and what the implications may be, was not known for many species. We analysed leaves and flowers of different taxa, separated into their different anatomical parts. Flowers mostly have low Si concentrations in all parts (mean ± SE of BSi in mg g−1was 0.22 ± 0.04 in petals, 0.59 ± 0.24 in sepals, 0.14 ± 0.03 in stamens, 0.15 ± 0.04 in styles and stigmas and 0.37 ± 0.19 in ovaries for a subset of 56 species). In most cases, less Si was accumulated in flowers than in leaves (mean ± SE of BSi in mg g−1was 1.51 ± 0.55 in whole flowers vs. 2.97 ± 0.57 in leaves in 104 species) though intriguing exceptions are found, with some species accumulating more Si in flowers than leaves. The large variation in concentration among flowers across the taxa examined, with a particularly high concentration in grass inflorescences, tantalisingly suggests differences in the use of Si for flowers across plant groups. We conclude that the study of the functions of Si for flowers warrants more attention, with pollination strategy a potential contributing factor.
Electro‐elucidation and quantification of olopatadine hydrochloride in bulk form and eye drops using modification free glassy carbon electrode with its development by different electrolytes and surfactants
Authors: El‐Attar Mona , Abdel‐Azzem Magdi 
Published: October 2023

AbstractThe electro‐oxidation pathway of olopatadine hydrochloride which is used in eye drops as antihistaminic agent was proposed and discussed in detail as the first time using different voltammetry methods at the modification free glassy carbon electrode surface. The oxidation process of olopatadine hydrochloride based on the presence of electro‐active tertiary amine group was irreversible. The dissociation constants were attained by the dependence of peak current and potential on the pH values. Some kinetic parameters were also estimated. Depending on the oxidation of olopatadine hydrochloride in citrate buffer (pH 5.5; 0.1 M) and sodium dodecyl sulfate (3×10−5 M) as supporting electrolyte and a modifier, respectively, sensitive, simple, accurate and inexpensive a novel square wave voltammetry method was achieved. The method was validated for linearity, precision, accuracy, ruggedness, specificity and stability. Limit of detection of 9×10−7 M in bulk form was attained. The characterized method was successfully used for routine analysis of olopatadine hydrochloride in pharmaceutical eye drops (Olohistine® and olopalite). No electroactive interferences from the inactive ingredients present in eye drops were noticed. So the proposed method does not necessitate any extraction step preceding the drug analysis. Also, the obtained data of the calibration curve and standard addition methods were compared statistically with a reported spectrophotometrically method showing no differences between them with respect to accuracy and precision, what proved the reproducibility, suitability and reliability of the described voltammetric method for assay of olopatadine hydrochloride in its formulation.
Modulation of physicochemical properties of lipid droplets using soy protein isolate and lactoferrin interfacial coatings
Authors: Zhang Chunlan , Du Mengyao , Li Bin 
Published: October 2023

AbstractIn order to improve the physicochemical stability of soy protein isolate (SPI) emulsion, lactoferrin (LF) was used to modify the interface layer. The stable multilayer emulsion can be formed when the content of lactoferrin is 0.5% at pH 5. The emulsion with good stability was at pH 3–7, and it was also stable to temperature change. The FFAs release of SPI emulsion and LF‐SPI emulsion was 103.9% and 103.7%, respectively. The results showed that the lactoferrin layer did not hinder the digestion of oil and the bioaccessibility of carotenoids, but lactoferrin layer improved the physicochemical stability of SPI emulsions. This work provides information valuable in the design of emulsion formulations for applications in the food, pharmaceutical, and personal care industries.
The impact of financial crises on social spending: Delving into the effects in developed and developing countries
Authors: Nguyen Thanh Cong , Castro Vítor , Wood Justine 
Published: October 2023

AbstractDespite expecting countries to rely on welfare measures in the aftermath of financial crises, one should not ignore the possibility of fiscal retrenchments due to the constraints that those crises may bring. This article analyses that issue by assessing the impact of financial crises on governmental social spending and its components (healthcare, education and social protection) using a panel of 108 countries from 1991 to 2019. An important contribution of this study is that it assesses the effects of different types of financial crises (banking, currency and debt) in addition to distinguishing between developed and developing countries. The findings indicate that while developed countries neutralise the adverse effects of crises by increasing social spending, developing countries tend to shrink outlays—in particular healthcare and social protection—when financial crises strike, despite the associated negative consequences on human and social well‐being. Moreover, debt crises proved to be more detrimental to social spending than banking and currency crises in developing countries. An important policy implication arising from our analysis is that governments should maintain a high level of fiscal balance in normal times to be able to finance welfare state expansion programmes during periods of financial crises, especially in emerging/developing countries.
Two different regimens of outpatient Foley catheter induction of labor in nulliparas: A randomized trial
Authors: Hong Jesrine , Raghavan Sreella , Siti Nordiana Ayub , Saaid Rahmah , Vallikkannu Narayanan , Tan Peng Chiong 
Published: October 2023

AbstractObjectivesTo evaluate expectant compared to immediate return to hospital upon outpatient Foley catheter expulsion predicated on maternal satisfaction and amniotomy‐titrated oxytocin infusion to delivery interval.MethodsThis randomized trial was conducted in a tertiary university hospital in Malaysia from September 2020 to February 2022. A total of 330 nulliparous women at term with unripe cervices (Bishop score ≤5), singleton viable fetus in cephalic presentation, reassuring preinduction fetal heart rate tracing and intact membranes who underwent planned outpatient Foley catheter induction of labor (IOL) were included. Women were randomized to expectant or immediate return to hospital if the Foley was spontaneously expelled at home before their scheduled hospital admission the following day. Primary outcomes were amniotomy‐titrated oxytocin infusion to delivery interval and maternal satisfaction on the induction process (assessed by 0–10 visual numerical rating scale [VNRS]).ResultsAmniotomy‐titrated oxytocin infusion to delivery interval was 8.7 ± 4.1 versus 8.9 ± 3.9 h, P = 0.605 (mean difference − 0.228 95% CI: −1.1 to +0.6 h) and maternal satisfaction VNRS score was median (interquartile range) 8 (7–9) versus 8 (7–9), P = 0.782. Early return to hospital rates were 37/165 (22.4%) versus 72/165 (43.6%), RR 0.51 (95% CI: 0.37–0.72), P ≤ 0.001, Cesarean delivery rates were 80/165 (48.5%) versus 80/165 (48.5%), RR 1.00 (95% CI: 0.80–1.25), P = 1.00 and duration of hospital stay was 54.4 ± 22.9 versus 56.7 ± 22.8 h, P = 0.364 for the expectant versus immediate return groups respectively.ConclusionIn outpatient Foley catheter IOL, expectant compared to immediate return to hospital following Foley dislodgement results in similarly high maternal satisfaction. The amniotomy‐titrated oxytocin to delivery duration is non‐inferior with expectant management.
The associations among well‐being comparisons and affective styles in depression, anxiety, and mental health quality of life
Authors: Schlechter Pascal , Morina Nexhmedin 
Published: October 2023

AbstractObjectiveFrame‐of‐reference theories suggest that individuals use different comparison types to evaluate their well‐being. Research indicates that the frequency of aversive well‐being comparisons is related to depression, with engendered comparison affective impact partly accounting for this relationship. We aimed to replicate this finding, examine whether this extends to anxiety and mental health quality of life, and whether these pathways are moderated by affective styles of concealing, adjusting, and tolerating. We expected concealing as a response‐focused style to be associated with higher effects of comparison affective impact on depression, anxiety, and mental health quality of life. Adjusting as an antecedent‐focused strategy was expected to mitigate the effects of aversive comparison frequency on comparison affective impact, and the effects of comparison affective impact on the outcomes. Finally, tolerating was expected to be associated with lower effects on both pathways.Methods and MeasuresParticipants (N = 596) responded to measures of well‐being comparisons, affective styles, depression, anxiety, and mental health quality of life.ResultsFrequency of aversive well‐being comparisons was associated with all outcomes. These relationships were partially mediated by comparison affective impact. Adjustment moderated the pathway between aversive comparison frequency and comparison affective impact. No other moderation effect emerged.ConclusionThe comparison process appears important in well‐being evaluations.
Heat consumption and modeling of corn seeds intermittent drying
Authors: Raimundini Aranha Ana Caroline , Lopes Ferrari Andressa , Paschoal Sirlei Marques , Sgorlon Juliana Guerra , Sérgi Gomes Maria Carolina , de Matos Jorge Luiz Mario , Tonin Lilian Tatiani Dusman , Oliveira Defendi Rafael 
Published: October 2023

AbstractBackgroundCorn seed is produced on a large scale, and as production is carried out seasonally, the storage is needed to supply uninterrupted demand. To carry out the storage, as the material from the harvest has a high initial moisture content, it is necessary to carry out the drying process. In order to reduce energy consumption, an alternative is intermittent drying. The purpose of this article is to fit the mathematical model of intermittent drying by distributed parameters, based on experimental data of temperature and moisture content of corn seeds submitted to intermittent drying, to determine the diffusivity value and to assess heat consumption.ResultsFor samples dried to the final moisture content of 16.0% on dry basis (d.b.), the condition of intermittent drying at a temperature of 40°C and 10 min of tempering period led to the lowest heat consumption, in comparison to conventional drying and to intermittent drying under higher temperatures. In addition, to obtain a final moisture content of 14.0% (d.b.), the conventional drying condition at 55°C resulted in the lowest heat consumption, compared to the other drying conditions. The distributed parameter model can predict the experimental data with a global deviation lower than 10.0%.ConclusionAnalyzing the moisture distribution profiles for the corn seeds, it was verified that there was a difference in the moisture content along the position inside the material, being necessary to evaluate the influence of moisture distribution along the position inside the material in kinetic drying models.
The role of surgery for anaplastic thyroid carcinoma in the era of targeted therapeutics: A scoping review
Authors: Cleere Eoin F. , Crotty Thomas J. , Hintze Justin M. , Fitzgerald Conall W. R. , Kinsella John , Lennon Paul , Timon Conrad V. I. , Woods Robbie S. R. , Shine Neville P. , O'Neill James P. 
Published: October 2023

AbstractBackgroundQuestions exist regarding patient selection for surgery in anaplastic thyroid carcinoma (ATC), particularly with the advent of neoadjuvant‐targeted therapeutics. The present scoping review sought to evaluate what extent of surgical resection should be performed in ATC.MethodsA scoping review was carried out in accordance with Joanna Briggs Institute and the preferred reporting items for systematic reviews and meta‐analyses extension for scoping reviews (PRISMA‐ScR) protocols. Included studies were required to provide clear description of the surgery performed for ATC.ResultsThe final search identified 6901 articles. Ultimately only 15 articles including 1484 patients met inclusion criteria. A total of 765 patients (51.5%) underwent attempted curative intent surgery. The approach to resection of adjacent tissues varied between studies. Eight studies considered laryngeal ± pharyngeal resection (8/15, 53.3%), eight studies (53.3%) considered tracheal resection and again eight studies (53.3%) considered esophageal resection. More extensive resections increased morbidity without improving overall survival (OS) (<9 months in the 12 studies using a combination of surgery and chemoradiotherapy). In the three studies utilizing targeted therapy in addition to surgery, OS was notably improved while surgical resection following neoadjuvant therapy was less extensive.ConclusionsThere is no clear agreement in the literature regarding the limits of surgical resection in locoregionally advanced ATC. A definition of surgically resectable disease will be required to guide surgical decision making in ATC, particularly with the potential to reduce tumor burden using neoadjuvant targeted treatment in suitable patients.Level of evidenceIII
How technological and natural consumption experiences impact consumer well‐being: The role of consumer mindfulness and fatigue
Authors: Zarantonello Lia , Grappi Silvia , Formisano Marcello 
Published: October 2023

AbstractNew technologies are becoming increasingly common in consumers' daily lives, and they are significantly changing consumer experiences. Given the novelty and pervasiveness of these technologies, understanding their effects on consumer well‐being is important. This research explores how technological versus natural experiences in consumption contribute to consumer well‐being, which is defined as happiness (with its components of pleasure and meaning) and life satisfaction. The results demonstrate that the type of experience (i.e., natural or technological) affects meaning and pleasure and, consequently, life satisfaction. These effects depend on two individual characteristics: consumer mindfulness and fatigue. When consumer mindfulness is high, the type of experience does not affect pleasure and meaning as consumers consistently derive high levels of both components of happiness. However, when their mindfulness is low, pleasure depends on the type of experience. Similar patterns are observed for meaning, although this is affected by the level of fatigue felt by consumers. Therefore, meaning is affected by the two individual characteristics of mindfulness and fatigue. By demonstrating the importance of consumer mindfulness in protecting individuals from fatigue and the potential negative effects associated with technological and natural consumption experiences, this study identifies practical insights that can be used to shape technological and natural experiences that support consumer well‐being.
Temperature field optimization for laser powder bed fusion as a traveling salesperson problem with history
Authors: Wang Gradey , Darve Eric , Lew Adrian J. 
Published: October 2023

AbstractLaser Powder Bed Fusion (LPBF) is a form of metal additive manufacturing in which a laser traces a path on a metal powder bed to heat powder particles and progressively melt and/or fuse them together to form a part. Outcomes of LPBF are functions of the metal's temperature history and are strongly affected by the path traced by the laser. Using temperature field optimization for LPBF as a motivating application, we focus on a class of combinatorial problems where admissible control policies are a permutation of a set of control actions. We abstract this class of problems as an optimal control problem with the objective of identifying an admissible control policy that minimizes a cost function of a dynamical system's state. While, in principle, the effect of the control actions on the cost function can last an infinitely long time, we will consider systems in which the effects of these control actions can be considered to last short (finite) periods of time. In this paper, we formalize this class of combinatorial problems as a Traveling Salesperson Problem with History and prove its equivalence to an Equality Generalized Traveling Salesperson Problem (E‐GTSP), enabling the use of well‐developed E‐GTSP solvers. We demonstrate this equivalence by computing the solutions obtained using an E‐GTSP solver for an LPBF‐inspired application.
Local element operations for curved simplex meshes
Authors: Shi A. , Persson P.‐O. 
Published: October 2023

SummaryMesh optimization procedures are generally a combination of node smoothing and discrete operations which affect a small number of elements to improve the quality of the overall mesh. These procedures are useful as a post‐processing step in mesh generation procedures and in applications such as fluid simulations with severely deforming domains. In order to perform high‐order mesh optimization, these ingredients must also be extended to high‐order (curved) meshes. In this work, we present a method to perform local element operations on curved meshes. The mesh operations discussed in this work are edge/face swaps, edge collapses, and edge splitting (more generally refinement) for triangular and tetrahedral meshes. These local operations are performed by first identifying the patch of elements which contain the edge/face being acted on, performing the operation as a “straight‐sided one" by placing the high‐order nodes via an isoparametric mapping from the master element, and smoothing the high‐order nodes on the elements in the patch by minimizing a Jacobian‐based high‐order mesh distortion measure. Since the initial “straight‐sided guess” from the placement of the nodes via the isoparametric mapping frequently results in invalid elements, the distortion measure must be regularized which allows for mesh untangling for the optimization to succeed. We present several examples in 2D and 3D to demonstrate these local operations and how they can be combined with a high‐order node smoothing procedure to maintain mesh quality when faced with severe deformations.