bluuebunny/crossref_metadata_2025_split huggingface dataset:
Trust, distrust, and open‐book accounting in three client‐vendor relationships
Authors: Agndal Henrik , Nilsson Ulf 
Published: October 2023

AbstractExtant management accounting research has conceptualized the interplay between trust, distrust, and open‐book accounting (OBA) as a relationship‐level phenomenon, largely ignoring that inter‐organizational relationships are often complex entities that comprise multiple arenas of exchange where (dis)trust and OBA can interact in different—and potentially contradictory—ways. To address this theoretical oversight, we draw on relational exchange theory to propose that (dis)trust largely forms within OBA domains where different forms of data are exchanged for different purposes. Trust and distrust may thereby coexist within a relationship. We also propose that (dis)trust spills over to influence the conditions for OBA in other domains. Consequently, trust and distrust not only take shape in cumulative processes within OBA domains but also diffuse between domains in a relationship. Empirical observations from a longitudinal case study of a retail buyer's attempts to introduce OBA in three vendor relationships lead us to suggest that competence‐trust spillover is determined largely by domain similarity, while goodwill‐trust spillover relies to a greater extent on staff mobility between OBA domains. Overall, the negative effects of distrust spillover on the implementation of OBA appear greater than the positive effects of trust spillover. Our study shows that, by analyzing the domain‐specific nature of trust and distrust, future research can increase our understanding of the relationship between data characteristics and (dis)trust, as well as explain how trust and distrust interact to determine conditions for data exchange between organizations.
Association between torquetenovirus in vaginal secretions and infertility: An exploratory metagenomic analysis
Authors: Da Costa A. Charlys , Bortoletto Pietro , Spandorfer Steven D. , Tozetto‐Mendoza Tania Regina , Linhares Iara M. , Mendes‐Correa Maria Cassia , Witkin Steven S. 
Published: October 2023

AbstractProblemThe association of viruses with infertility remains incompletely evaluated.Method of studyVaginal secretions from 46 women seeking treatment in the Center for Reproductive Medicine and Infertility at Weill Cornell Medicine were tested for viruses by metagenomic analysis by lab personnel blinded to all clinical data.ResultsTorquetenovirus (TTV) was identified in 16 women, alphapapillomavirus in seven women and most were positive for bacteriophages. Twelve of the subjects were fertile and sought to freeze their oocytes for future implantation. These women were all negative for TTV. In contrast, 16 of the 34 women (47.1%) being treated for infertility were TTV‐positive (p = .0035). Evaluating the women by cause of infertility, five of nine women (55.6%) whose male partner had inadequate sperm parameters and six of 14 women (42.9%) with defective ovulation were TTV positive (p = .0062 and p = .0171, respectively, vs. the fertile women). Alphapapillomavirus was identified in one (8.3%) fertile woman, five (35.7%) women with ovulation deficiency, and one (11.1%) woman with male factor infertility. These differences were not statistically significant. There were no differences in bacteriophage families or the presence of Lactobacillus phages between fertile or infertile women or between different causes of infertility. There was a negative association between TTV detection and Lactobacillus crispatus dominance in the vaginal microbiota (p = .0184), but no association between TTV detection and the presence of alphapapillomavirus or Candida species.ConclusionDetection of TTV in the vagina might be a biomarker for specific causes of infertility.
Vitamin D deficiency associated with neurodevelopmental problems in 2‐year‐old Japanese boys
Authors: Yasumitsu‐Lovell Kahoko , Thompson Lucy , Fernell Elisabeth , Eitoku Masamitsu , Suganuma Narufurmi , Gillberg Christopher ,   the Japan Environment and Children's Study Group
Published: October 2023

AbstractAimWhile associations between vitamin D deficiency and neurodevelopmental disorders have been found, large studies on child vitamin D, neurodevelopment, and sex differences among the general population are lacking. This study aimed to investigate the association between child serum 25‐hydroxyvitamin D (25(OH)D)) levels and neurodevelopmental problems (NDPs).MethodsSerum 25(OH)D and NDPs were measured at age two among the subcohort study of the Japan Environment and Children's Study. NDPs were assessed with the Kyoto Scale of Psychological Development 2001 (Kyoto scale). Adjusted odds ratios (aORs) for the Kyoto‐scale developmental quotient scores <70 were calculated, for postural–motor, cognitive–adaptive, and language–social domains and overall scores, adjusted for test month, latitude, small for gestational age, maternal age, and daycare attendance.ResultsAmong 2363 boys and 2290 girls, boys had higher 25(OH)D levels, but scored lower in the Kyoto scale. For boys in the vitamin D deficiency (<20 ng/mL) group, aORs of scoring the Kyoto‐scale DQs <70 were 2.33 (p = 0.006) for overall DQs, 1.91 (p = 0.037) for cognitive–adaptive, and 1.69 (p = 0.024) for language–social domains. For girls, results were inconclusive.ConclusionOnly boys showed a clear and cross‐modal association between vitamin D deficiency and NDPs.
How well do collaboration quality estimation models generalize across authentic school contexts?
Authors: Chejara Pankaj , Kasepalu Reet , Prieto Luis P. , Rodríguez‐Triana María Jesús , Ruiz Calleja Adolfo , Schneider Bertrand 
Published: October 2023

AbstractMultimodal learning analytics (MMLA) research has made significant progress in modelling collaboration quality for the purpose of understanding collaboration behaviour and building automated collaboration estimation models. Deploying these automated models in authentic classroom scenarios, however, remains a challenge. This paper presents findings from an evaluation of collaboration quality estimation models. We collected audio, video and log data from two different Estonian schools. These data were used in different combinations to build collaboration estimation models and then assessed across different subjects, different types of activities (collaborative‐writing, group‐discussion) and different schools. Our results suggest that the automated collaboration model can generalize to the context of different schools but with a 25% degradation in balanced accuracy (from 82% to 57%). Moreover, the results also indicate that multimodality brings more performance improvement in the case of group‐discussion‐based activities than collaborative‐writing‐based activities. Further, our results suggest that the video data could be an alternative for understanding collaboration in authentic settings where higher‐quality audio data cannot be collected due to contextual factors. The findings have implications for building automated collaboration estimation systems to assist teachers with monitoring their collaborative classrooms.
Practitioners notesWhat is already known about this topic

Multimodal learning analytics researchers have established several features as potential indicators for collaboration quality, e.g., speaking time or joint visual attention.

The current state of the art has shown the feasibility of building automated collaboration quality models.

Recent research has provided preliminary evidence of the generalizability of developed automated models across contexts different in terms of given task and subject.

What does this paper add

This paper offers collaboration indicators for different types of collaborative learning activities in authentic classroom settings.

The paper includes a systematic investigation into collaboration quality automated model's generalizability across different tasks, types of tasks and schools.

This paper also offers a comparison between different modalities' potential to estimate collaboration quality in authentic settings.

Implications for practice

The findings inform the development of automated collaboration monitoring systems for authentic classroom settings.

This paper provides evidence on across‐school generalizability capabilities of collaboration quality estimation models.
Formation and clearance of TNF–TNF inhibitor complexes during TNF inhibitor treatment
Authors: Berkhout Lea Catharina , I'Ami Merel Jeanne , Kruithof Simone , Vogelzang Erik Hans , Hooijberg Femke , Hart Margaretha Hendrika Louise , Bentlage Arthur Ebel Herman , Thomas Debby , Vermeire Severine , Vidarsson Gestur , ten Brinke Anja , Nurmohamed Michael Twahier , Wolbink Gerrit Jan , Rispens Theo 
Published: October 2023

AbstractBackground and PurposeMillions of patients with inflammatory diseases are treated with tumour necrosis factor (TNF) inhibitors (TNFi). Individual treatment response varies, in part related to variable drug clearance. The role of TNF–TNFi complexes in clearance of the different TNFi is controversial. Moreover, mechanistic insight into the structural aspects and biological significance of TNF–TNFi complexes is lacking. We hypothesized a role for Fc‐mediated clearance of TNF–TNFi immune complexes. Therefore, we investigated circulating TNF–TNFi complexes upon treatment with certolizumab—lacking Fc tails—in comparison with adalimumab, golimumab, infliximab and etanercept.Experimental ApproachDrug‐tolerant ELISAs were developed and used to quantify TNF during adalimumab, golimumab, etanercept, certolizumab and infliximab treatment in patients with inflammatory arthritis or ulcerative colitis for a maximum follow‐up of 1 year. Effects on in vitro TNF production and Fc‐mediated uptake of TNF–TNFi complexes were investigated for all five TNFi.Key ResultsCirculating TNF concentrations were >20‐fold higher during certolizumab treatment compared with adalimumab, reaching up to 23.1 ng·ml−1. Internalization of TNF–TNFi complexes by macrophages depended on Fc valency, with efficient uptake for the full antibody TNFi (three Fc tails), but little or no uptake for etanercept and certolizumab (one and zero Fc tail, respectively). TNF production was not affected by TNFi. Total TNF load did not affect clearance rate of total TNFi.Conclusions and ImplicationsDifferences in TNFi structure profoundly affect clearance of TNF, while it is unlikely that TNF itself significantly contributes to target‐mediated drug disposition of TNFi.
Omega‐3 fatty acids and endothelial function: A GRADE‐assessed systematic review and meta‐analysis
Authors: Arabi Seyyed Mostafa , Bahari Hossein , Chambari Mahla , Bahrami Leila Sadat , Mohaildeen Gubari Mohammaed Ibrahim , Watts Gerald F. , Sahebkar Amirhossein 
Published: October 2023

AbstractIntroductionN‐3 polyunsaturated fatty acids (PUFAs) supplementation has been reported to have an impact on flow‐mediated dilatation (FMD), a conventionally used clinical technique for estimating endothelial dysfunction. However, its proven effects on endothelial function are unclear. This systematic review and meta‐analysis were conducted to evaluate the effects of n‐3 PUFAs supplementation on FMD of the brachial artery.MethodThis study was performed following the PRISMA guidelines. To identify eligible RCTs, a systematic search was completed in PubMed/Medline, Scopus and Web of Science using relevant keywords. A fixed‐ or random‐effects model was utilized to estimate the weighted mean difference (WMD) and 95% confidence interval (95% CI).ResultsThirty‐two studies (with 35 arms) were included in this meta‐analysis, involving 2385 subjects with intervention duration ranging from 4 to 48 weeks. The pooled meta‐analysis demonstrated a significant effect of omega‐3 on FMD (WMD = 0.8%, 95% CI = 0.3–1.3, p = .001) and heterogeneity was significant (I2 = 82.5%, p < .001).ConclusionWe found that n‐3 PUFA supplementation improves endothelial function as estimated by flow‐mediated dilatation of the brachial artery.
Post‐stroke immunosuppression: Exploring potential implications beyond infections
Authors: Brea David 
Published: October 2023

AbstractStroke is a leading cause of mortality and disability. It occurs when cerebral blood flow is disrupted via vascular occlusion or rupture, causing tissue damage. Research has extensively examined the role of the immune response in stroke pathophysiology, focusing on infiltrated immune cells and inflammatory molecules. However, the stroke's impact on immune physiology remains underexplored. While initially stroke triggers the activation of peripheral inflammation, a subsequent profound immunosuppression occurs in a matter of hours/days. This response, potentially shielding the brain from excessive inflammation, significantly affects stroke patients. Beyond rendering patients more susceptible to infections, immunosuppression generates diverse consequences by disrupting immune system functions that are crucial for organ homeostasis. This review explores the effects of immunosuppression on stroke patients, shedding light on potential issues in immune organs such as the spleen and bone marrow, as well as non‐immune organs like the small intestine, liver and heart. By synthesizing existing literature and offering additional insights, this manuscript highlights the multifaceted impact of post‐stroke immunosuppression.
Disrupted topologic efficiency of brain functional connectome in de novo Parkinson's disease with depression
Authors: Wang Hui , Zhan Xiaoyan , Xu Jianxia , Yu Miao , Guo Zhiying , Zhou Gaiyan , Ren Jingru , Zhang Ronggui , Liu Weiguo 
Published: October 2023

AbstractGrowing evidence supports that depression in Parkinson's disease (PD) depends on disruptions in specific neural networks rather than regional dysfunction. According to the resting‐state functional magnetic resonance imaging data, the study attempted to decipher the alterations in the topological properties of brain networks in de novo depression in PD (DPD). The study also explored the neural network basis for depressive symptoms in PD. We recruited 20 DPD, 37 non‐depressed PD and 41 healthy controls (HC). The Graph theory and network‐based statistical methods helped analyse the topological properties of brain functional networks and anomalous subnetworks across these groups. The relationship between altered properties and depression severity was also investigated. DPD revealed significantly reduced nodal efficiency in the left superior temporal gyrus. Additionally, DPD decreased five hubs, primarily located in the temporal‐occipital cortex, and increased seven hubs, mainly distributed in the limbic cortico‐basal ganglia circuit. The betweenness centrality of the left Medio Ventral Occipital Cortex was positively associated with depressive scores in DPD. In contrast to HC, DPD had a multi‐connected subnetwork with significantly lower connectivity, primarily distributed in the visual, somatomotor, dorsal attention and default networks. Regional topological disruptions in the temporal‐occipital region are critical in the DPD neurological mechanism. It might suggest a potential network biomarker among newly diagnosed DPD patients.
Cover crop identity determines root fungal community and arbuscular mycorrhiza colonization in following main crops
Authors: García‐González Irene , Martínez‐García Laura B. , Barel Janna M. , Martens Henk , Snoek L. Basten , Hontoria Chiquinquirá , De Deyn Gerlinde B. 
Published: October 2023

AbstractCover crops (CC) can promote nutrient retention and recycling for main crops yet may also promote soilborne pathogens or suppress beneficial root symbionts such as arbuscular mycorrhizal fungi (AMF). We investigated how root fungal communities of main crop are affected by preceding CC monocultures and mixtures and by main crop identity. We expected that AMF abundance and diversity in main crops are promoted by AM‐host CC, and suppressed by non‐AM‐host CC, and that mixtures of CC species can promote beneficial and suppress pathogenic root fungi. Our full‐factorial field experiment comprised crop rotation in sand soil with different CC treatments (monocultures of radish [AM non‐host], ryegrass, clover, vetch [AM hosts], mixtures of radish + vetch, ryegrass + clover and fallow) and two main crops (oat and endive). At peak crop growth, we investigated the root fungal communities in the main crops using microscopy and high throughput sequencing (Illumina MiSeq). Cover crop identity was of prime importance and CC legacy overruled main crop identity in determining root fungal communities in main crops. Compared with fallow, CC with ryegrass increased AMF colonization and richness in both main crops and of non‐AMF in oat. Legacies of ryegrass, ryegrass + clover and vetch resulted in distinct root fungal communities in the main crops, while the legacy of CC with radish were similar to the legacy of fallow. Root fungal community in crops after clover had highest abundance of representative fungal pathogens in contrast with the other CC treatments that resulted in fungal communities where pathogens were scarce. Oppositely to expected, CC mixtures did not enhance fungal symbionts or suppressed pathogens. Overall, fungal communities in roots of the main crops in our field experiment were determined by the preceding CC species in monoculture, rather than by the CC AMF preference or functional group. This research highlights that the choice of CC determines the root fungal community in main crop which may influence crop quality.
Optimal pricing strategies and decision‐making systems in e‐commerce using integrated fuzzy multi‐criteria method
Authors: Shan Wenli 
Published: October 2023

AbstractE‐commerce online stores are now virtual platforms for connecting with millions of potential clients worldwide in the age of digitization. The marketing teams develop digital marketing tactics to attract traffic to their e‐commerce sites and increase sales volume. With the vast amount of data provided by the cloud, decisions that were previously made with a significant level of intuition based on the knowledge and experience of decision‐makers can now be backed using artificial intelligence algorithms. To identify the variables influencing pricing decisions for products launched on e‐commerce shopping sites and to develop variable pricing techniques for each product found on an e‐commerce site. This paper introduces a novel approach that applies Fuzzy association rule mining (FARM) and Fuzzy TOPSIS MCDM methodology. A B2B e‐commerce marketing store based in Hong Kong has created and implemented Smart‐Quo, a pricing decision support system for B2B e‐commerce retail businesses. After a six‐month trial period, there has been a substantial advance in the effectiveness and efficiency of choosing prices for each product. The case study illustrates the viability and potential advantages of implementing artificial intelligence tools in marketing management in the digital era.
Epothilone B loaded in acellular nerve allograft enhanced sciatic nerve regeneration in rats
Authors: Omar Khudhur Zhikal , Ziyad Abdulqadir Shang , Faqiyazdin Ahmed Mzury Abdullah , Aziz Rasoul Abdulrahman , Wasman Smail Shukur , Ghayour Mohammad B. , Abdolmaleki Arash 
Published: October 2023

AbstractBackgroundEpothilone B (EpoB) is a microtubule‐stabilizing agent with neuroprotective properties.ObjectivesThis study examines the regenerative properties of ANA supplemented with EpoB on a sciatic nerve deficit in male Wistar rats.MethodsFor this purpose, the 10 mm nerve gap was filled with acellular nerve allografts (ANAs) containing EpoB at 0.1, 1, and 10 nM concentrations. The sensorimotor recovery was evaluated up to 16 weeks after the operation. Real‐time PCR, histomorphometry analysis, and electrophysiological evaluation were also used to evaluate the process of nerve regeneration.ResultsANA/EpoB (0.1 nM) significantly improved sensorimotor recovery in rats compared to ANA, ANA/EpoB (1 nM), and ANA/EpoB (10 nM) groups. This led to reduced muscle atrophy, improved sciatic functional index, and thermal paw withdrawal reflex latency, indicating nerve regeneration and target organ reinnervation. The electrophysiological and histomorphometry findings also confirmed the ANA/EpoB regenerative properties (0.1 nM). EpoB only enhanced ANA regenerative properties at 0.1 nM, with no therapeutic effects at higher concentrations.ConclusionTotally, we concluded that ANA loaded with 0.1 nM EpoB can effectively reconstruct the transected sciatic nerve in rats, likely by enhancing axonal sprouting and extension.
An exploration of healthcare use in older people waiting for and receiving Australian community‐based aged care services
Authors: Edney Laura C. , Haji Ali Afzali Hossein , Visvanathan Renuka , Toson Barbara , Karnon Jonathan 
Published: October 2023

AimHome care packages (HCPs) facilitate older individuals to remain at home, with longer HCP wait times associated with increased mortality risk. We analyze healthcare cost data pre‐ and post‐HCP access to inform hypotheses around the effects of healthcare use and mortality risk.MethodsRegression models were used to assess the impact of delayed HCP access on healthcare costs and to compare costs whilst waiting and in the 6‐ and 12 month periods post‐HCP access for 16 629 older adults.ResultsAverage wait time for a HCP was 89.7 days (SD = 125.6) during the study period. Wait‐time length had no impact on any healthcare cost category or time period. However, total per day healthcare costs were higher in the 6 and 12 months post‐receipt of a HCP (AU$61.5, AU$63, respectively) compared with those in the time waiting for a HCP (AU$48.1). Inpatient care accounted for a higher proportion of total healthcare costs post‐HCP (AU$45.1, AU$46.3, respectively) compared with in the wait time (AU$30.6), whilst spending on medical services and pharmaceuticals reduced slightly in the 6 month (AU$7.1, AU$6.3) and 12 month (AU$7.2, AU$6.3) post‐HCP periods compared with in the wait time (AU$7.9, AU$7.1).ConclusionsIncreased spending post‐HCP on inpatient care or non‐health support afforded by HCPs may offer protective effects for mortality and risk of admission to aged care. Further research should explore the association between delayed access to inpatient care for geriatric syndromes and mortality to inform recommendations on extensions to residential care outreach services into the community to improve the timely identification of the need for inpatient care. Geriatr Gerontol Int 2023; 23: 899–905.
Pleurotus geesteranus mycelium proteins: physicochemical and functional properties
Authors: Xv Wanting , Qiu Zijie , Zheng Qianwang , Ye Zhiwei , Wei Tao , Guo Liqiong , Lin Junfang , Zou Yuan 
Published: October 2023

SummaryIn the present work, the physicochemical and functional properties, as well as the digestion behaviour of Pleurotus geesteranus mycelium protein isolates (PMPI), were investigated. SDS‐PAGE results found that the molecular weight of PMPI was mainly concentrated in >100 kDa and <25 kDa and a total of 365 proteins were detected with proteome analysis. The contents of secondary structures in PMPI were as follows: β‐sheet (27.15%) > α‐helix (23.23%) > random coil (21.92%) > β‐turn (17.21%) > β‐antiparallel (10.48%). The total sulphydryl, free sulphydryl and disulphide bond content of PMPI were 29.88, 9.77 and 10.05 μmol/g respectively. The denaturation temperature of PMPI was measured at 92.94 °C, with an enthalpy change of 39.76 J/g. However, PMPI showed poor solubility, leading to relatively low foaming properties and emulsion activity. The nitrogen release rate of PMPI was 21.78% after pepsin digestion and 74.60% at the end of trypsin digestion.