bluuebunny/crossref_metadata_2025_split huggingface dataset:
PAR-4/LKB1 prevents intestinal hyperplasia by restricting endoderm specification in Caenorhabditis elegans embryos
Authors: Demouchy Flora , Nicolle Ophélie , Michaux Grégoire , Pacquelet Anne 
Published: December 2023

ABSTRACT
The kinase PAR-4/LKB1 is a major regulator of intestinal homeostasis, which prevents polyposis in humans. Moreover, its ectopic activation is sufficient to induce polarization and formation of microvilli-like structures in intestinal cell lines. Here, we use Caenorhabditis elegans to examine the role of PAR-4 during intestinal development in vivo. We show that it is not required to establish enterocyte polarity and plays only a minor role in brush border formation. By contrast, par-4 mutants display severe deformations of the intestinal lumen as well as supernumerary intestinal cells, thereby revealing a previously unappreciated function of PAR-4 in preventing intestinal hyperplasia. The presence of supernumerary enterocytes in par-4 mutants is not due to excessive cell proliferation, but rather to the abnormal expression of the intestinal cell fate factors end-1 and elt-2 outside the E lineage. Notably, par-4 mutants also display reduced expression of end-1 and elt-2 inside the E lineage. Our work thereby unveils an essential and dual role of PAR-4, which both restricts intestinal specification to the E lineage and ensures its robust differentiation.
Programming human cell fate: overcoming challenges and unlocking potential through technological breakthroughs
Authors: Lin Hsiu-Chuan , Makhlouf Aly , Vazquez Echegaray Camila , Zawada Dorota , Simões Filipa 
Published: December 2023

ABSTRACT
In recent years, there have been notable advancements in the ability to programme human cell identity, enabling us to design and manipulate cell function in a Petri dish. However, current protocols for generating target cell types often lack efficiency and precision, resulting in engineered cells that do not fully replicate the desired identity or functional output. This applies to different methods of cell programming, which face similar challenges that hinder progress and delay the achievement of a more favourable outcome. However, recent technological and analytical breakthroughs have provided us with unprecedented opportunities to advance the way we programme cell fate. The Company of Biologists’ 2023 workshop on ‘Novel Technologies for Programming Human Cell Fate’ brought together experts in human cell fate engineering and experts in single-cell genomics, manipulation and characterisation of cells on a single (sub)cellular level. Here, we summarise the main points that emerged during the workshop's themed discussions. Furthermore, we provide specific examples highlighting the current state of the field as well as its trajectory, offering insights into the potential outcomes resulting from the application of these breakthrough technologies in precisely engineering the identity and function of clinically valuable human cells.
Unidirectional scattering induced by magnetic dipoles in core–shell nanostructures
Authors: Zhang Xiaoming , Hu Yu , Yu Jinjing , Zhou Leiqing , Zhang Zhaogang , Yuan Yijun , Zhou Xia , Wang Haiyan , Wu Chao , Xie Fang , Xie Biao , Zhang Tianyue , Liu Jianping 
Published: December 2023

Unidirectional scattering is typically achieved through the interference of induced electric and magnetic dipole modes in nanophotonics. However, there are limited studies on achieving unidirectional scattering solely through magnetic dipole (MD) moments. Here, we propose and demonstrate that the extraordinary unidirectional scattering can be obtained in a pair of closely spaced MDs in a Si–Au core–shell dimer. The conditions for such unidirectional scattering are derived using the dipole approximation. Calculated with the coupled dipole method, a pronounced unidirectionality (up to 60 dB) in the forward scattering can be achieved with the dimer system. This can be attributed to the destructive interference of scattered far field from the induced MDs. Interestingly, the scattering direction could be controlled by varying the position of the element in the dimer and the main lobe angle of the far field can be efficiently induced by the antenna array. Furthermore, a remarkable forward-to-backward directionality can also be achieved when a magnetic dipole emitter is close to the Si–Au core–shell particle. These findings indicate the potential of this simple yet versatile platform for manipulating scattering.
Physical measures of physical functioning as prognostic factors to predict outcomes in low back pain: Protocol for a systematic review
Authors: Rashed Rameeza , Kowalski Katie , Walton David , Niazigharemakhe Afieh , Rushton Alison 
Published: December 2023

Background
Low back pain (LBP) is a highly prevalent condition that substantially impairs individuals’ physical functioning. This highlights the need for effective management strategies to improve patient outcomes. It is, therefore, crucial to have knowledge of physical functioning prognostic factors that can predict outcomes to facilitate the development of targeted treatment plans aiming to achieve better patient outcomes. There is no synthesis of evidence for physical functioning measures as prognostic factors in the LBP population. The objective of this systematic review is to synthesize evidence for physical measures of physical functioning as prognostic factors to predict outcomes in LBP.

Methods
The protocol is registered in the International Prospective Register of Systematic Reviews and reported in line with the Preferred Reporting Items for Systematic Review and Meta-Analysis Protocols (PRISMA-P). Prospective longitudinal observational studies investigating potential physical prognostic factors in LBP and/or low back-related leg pain population will be included, with no restriction on outcome. Searches will be performed in MEDLINE, EMBASE, Scopus, CINAHL databases, grey literature search using Open Grey System and ProQuest Dissertations and Theses, hand-searching journals, and reference lists of included studies. Two independent reviewers will evaluate the eligibility of studies, extract data, assess risk of bias and quality of evidence. Risk of bias will be assessed using the Quality in Prognostic Studies (QUIPS) tool. Adequacy of clinical, methodological, and statistical homogeneity among included studies will decide quantitative (meta-analysis) or qualitative analysis (narrative synthesis) focused on prognostic factors and strength of association with outcomes. Quality of cumulative evidence will be evaluated using a modified Grading of Recommendations Assessment, Development, and Evaluation (GRADE).

Discussion
Information about prognostic factors can be used to predict outcomes in LBP. Accurate outcome prediction is essential for identifying high-risk patients that allows targeted allocation of healthcare resources, ultimately reducing the healthcare burden.

Registration
PROSPERO, CRD42023406796.
INVOLVEMENT OF YOUNG PEOPLE AS A STRATEGIC RESOURCE OF THE KNOWLEDGE ECONOMY IN INNOVATIVE ACTIVITIES: THE EXPERIENCE OF THE KIROV REGION
Authors: Sennikova I. L. , Selina V. K. 
Published: December 2023

Innovative and sustainable development of each region and the country as a whole in the context of the dynamic development of science and technology is receiving increasing attention from the state and society. Thus, as one of the key goals of the priority direction “Development of economic potential” of the strategy of socioeconomic development of the Kirov region for the period up to 2035, approved by the decree of the Government of the Kirov region dated 28.04.2021 No. 76, is the formation of a new efficient economy based on knowledge, the development of innovation, high-tech sectors of the economy, small and medium-sized businesses as the main conductor of mass innovations. Over the past few years, there has been a clear increase in the attention of the state and society to the formation of an innovative environment: legal norms regulating innovation activities are being developed and approved, infrastructure facilities for the development and support of innovations are being created, new methods of innovation support are being introduced both by authorities and by leading enterprises and organizations. A special role in this process is assigned to young people, who are the most progressive socio-demographic group. Young people are actively involved both in the process of generating innovative ideas and their further implementation; they play an important role in the implementation of social organizational innovations in the Kirov region. The article presents an analysis of regional infrastructure facilities for supporting and developing innovations, as well as key innovative organizational decisions in the social sphere, analyzes the reasons for the existing basic growth rate of indicators, and proposes mechanisms for involving young people in innovative activities.
Prispevek k recentni razširjenosti, ekologiji in varstvu močvirske sklednice Emys orbicularis (Linnaeus, 1758) v Beli krajini (JV Slovenija)
Authors: Vamberger Melita , Govedič Marijan , Lipovšek Gregor 
Published: December 2023

Although the European pond turtle is widespread in Bela krajina according to old data, very few recent data are available on its natural history and ecology from this region. Our goal was to determine the population structure of the European pond turtle of Bela krajina and its recent distribution. To do this, we caught and marked 48 individuals in the years 2008-2012. The European pond turtle was found in native and human-made water bodies of four areas. 40% of all caught individuals were up to 10 years of age. We confirmed reproduction at five localities (Prilozje, Zjot, Golek, oxbows of the Obrh stream, Nerajec) and registered nesting sites at ponds Golek and Gornji kal. The allochthonous red-eared slider turtle and yellow-bellied slider were also present at three localities. Our results indicate that the most stable population was found in the upper reaches of the Lahinja River, followed by oxbows of the Obrh stream near Metlika, and the environs of Prilozje and Hrast villages. We additionally present our conservation views and propose the Natura 2000 network to be expanded for this species.
Observations of amphibian, reptile and some mammal species in the area of Šaleška jezera near Velenje during the 2015–2017 period
Authors: Bolčina Anja , Gojznikar Jan , Kraševec Rudi , Gabor Matic , Vrhovšek Blaž 
Published: December 2023

In this contribution we present our observations of amphibians, reptiles and some mammals from the area of Šaleška jezera (lakes) near Velenje in northern Slovenia. This area refers to three lakes – Velenjsko jezero, Šoštanjsko jezero and Škalsko jezero, which were formed in the 20th century as a consequence of underground lignite mining. The landscape is still changing due to an ongoing subsidence of the valley caused by continuous mining, which constantly affects the surface water bodies and habitats. The changes are so apparent that they could be measured in weeks if not days. New records on the occurrence of 9 amphibian, 7 reptilian and 9 mammalian species were made in the region during our field work carried out from 2015 to 2017. Three of these species are listed on Annex II of the EU Habitats Directive – Emys orbicularis, Bombina variegata and Triturus carnifex, and additional eight on Annex IV of this directive – Bombina variegata, Hyla arborea, Rana dalmatina, Triturus carnifex, Emys orbicularis, Lacerta viridis, Podarcis muralis and Natrix tessellata. We also recorded two introduced species – Dama dama and Trachemys scripta.
Künste als Technologien der Selbst-Transformation
Authors: Mahrenholz Simone 
Published: December 2023

Abstract
The article presents the idea that works of art are technologies for self-transformation and contextualises this idea within the discursive field of “aesthetic thinking”. It takes L. A. Paul’s concept of “transformative experiences” as a reference point and analyses the materiality of music as an example for an artistic medium through which these transformations can be initiated in a paradigmatic way. Contemporary philosophies of art by Alva Noë, Georg Bertram, and Christoph Menke, all dealing with the influence of art on the self, are referenced and tentatively mapped onto one another, followed by a final presentation of twelve theses that subsume the leading ideas.
Die ästhetische Differenz
Authors: Alloa Emmanuel 
Published: December 2023

Abstract
Recent debates about aesthetics are characterized by a partly intentional, but also partly involuntary, vagueness. Whether it be aestheticisation or anesthetisation, articisation or desartification: what is upheld or deplored under one and the same label in fact designates rather different things. The paper makes a suggestion as to how the field could be reorganized. Taking heed of what political theory discusses as the “political difference” between “politics” and “the political”, the aim is to examine what would be gained by working with an “aesthetic difference” that does not straightforwardly equate “the aesthetic” with “art”, and “the aesthetic” with the totality of sensuous-aisthetic processes. An aesthetic thinking would then amount to a thinking that does justice to these inner polarities and remains faithful to the ambiguity of its objects.
Petrogenesis of the Morobe Granodiorite and their shoshonitic mafic microgranular enclaves in Maramuni arc, Papua New Guinea
Authors: Hoshide Takashi , Bokuik Angela , Ishikawa Tatsuki 
Published: December 2023

Abstract
The Miocene tectonics of Papua New Guinea, where subduction, arc-continent collision, and changes in subduction direction are considered to have occurred, is very complex and various tectonic models have been proposed. The Maramuni arc, active in the Miocene, is composed of a chain of granitoid bodies. As the chain-like distribution indicates the generation of igneous activities in a wide range of the same tectonic settings, the study of the Maramuni arc magmatism is important for elucidating the geologic events of the time. We provide data on the petrological and geochemical characteristics of the Morobe Granodiorite that form part of the Maramuni arc. The Morobe Granodiorite consists of metaluminous I-type granitoids, belonging to the medium-K to high-K series. The whole-rock major element variations in the granitoids can be explained by the fractionation of hornblende and plagioclase. They are generally within the composition range of experimental partial melts of amphibolites, and the whole-rock trace element compositions have characteristics of slab failure magma rather than arc. This suggests that the granitoids were generated by partial melting of the torn slab after slab failure. The mafic microgranular enclaves (MMEs) in the granitoids are classified as shoshonite, and their trace element compositions suggest that they were formed by partial melting of phlogopite-bearing mantle. The occurrences of native gold and barite within the MME show that MMEs transport Au from the mantle metasomatized by slab-derived sediment melt and/or fluid to the crustal magma chamber.
Environmental health risk assessment of urban water sources based on fuzzy set theory
Authors: Liao Di , Jin Yongsheng , Zhang Xiao 
Published: December 2023

Abstract
Water pollution and protection of water resources have become an urgent task for humanity today and are also important components of environmental risk assessment. In response to the problems of high risk level and low risk credibility in the current environmental health risk assessment of urban water sources, this article aims to use fuzzy set theory to comprehensively evaluate the environmental quality and quickly monitor the safety of urban water sources. Therefore, this article analyzed the health factors of the urban water source environment and then studied the content and uncertainty analysis of health risk assessment. Finally, it constructed a health risk assessment system and proposed corresponding water environment protection strategies. In the experimental section, the risk level and risk credibility of the water environment were analyzed. Through comparison, it was found that the risk level in the new water environment health risk assessment was 0.16 lower than that in the traditional water environment health risk assessment, and the risk credibility was 0.11 higher than that in the traditional water environment health risk assessment. The water quality monitoring effect in the new water environment health risk assessment was 7.3% higher than that in the traditional water environment health risk assessment, The health hazard effect is 8.2% lower than traditional water environment health risk assessment. In summary, water environment health risk assessment plays an important role in protecting the water source environment. Health risk assessment of the water environment helps to reduce water pollution, improve water quality, and ultimately improve human health. Moreover, using fuzzy set theory makes it easier to comprehensively and efficiently evaluate the water environment. The innovation of this article lies in paying attention to the importance of fuzzy set theory in water pollution risk assessment and applying fuzzy technology to water pollution control strategies, to better improve water quality and optimize water source environmental health risk assessment methods.
Constraction: a tool for the automatic extraction and interactive exploration of linguistic constructions
Authors: Yan Hengbin , Li Yinghui 
Published: December 2023

Abstract
A central task in empirical and quantitative language studies is the extraction of linguistic constructions important to linguistic theory and application. The great number and variety of such constructions increasingly necessitates computer-assisted extraction, which often proves challenging as it entails a simultaneous analysis of multiple layers of linguistic information latent in large-scale corpora. To address this, we present Constraction, an open-source tool for the automatic extraction and interactive exploration of linguistic constructions from arbitrary textual corpora. Constraction features a generic algorithm that integrates customizable layers of linguistic annotation (e.g., lexical, syntactic, and semantic) to identify constructional patterns of varying sizes and abstraction levels. Its browser-based interface allows users to configure various extraction parameters and enables visual, interactive exploration of the extracted patterns. We demonstrate the utility of Constraction through case studies and discuss its potential applications in language research and pedagogy.
Who navigates the “elite” of communication journals? The participation of BRICS universities in top-ranked publications
Authors: Comel Naiza , Marques Francisco Paulo Jamil , Prendin Costa Luiz Otávio , Kohls Chirlei , Orso Maíra 
Published: December 2023

Abstract

Purpose
Despite the increasing volume of research addressing the relevance of de-Westernizing Media Studies, we lack a comparative evaluation of the performance of Global South universities regarding their presence in the most prestigious domains within the field of Communication. Against this background, the article explores if and to what extent the publication of articles authored by BRICS-based scholars in top-ranked journals is restricted to a handful of academic institutions – making them a national “elite” authorized to engage in the mainstream intellectual debate.

Design/methodology/approach
We pose three questions: RQ1) To what extent is the academic output of BRICS countries in the field of Communication concentrated within a select few “top-level” institutions? RQ2) How are the research articles from the most productive universities distributed across the journal rankings comprising the SJR database? RQ3) What partnerships do institutions from BRICS countries engage in when producing research articles? Using data from the SciVal (Elsevier) and SJR (SCImago Journal Rank) platforms, the empirical study encompasses a set of articles published between 2012 and 2021.

Findings
Our findings reveal that South Africa, Russia, and Brazil had the highest concentration of academic production within a select few universities. The disparities among the most and least productive universities can be attributed to a lack of ambitious policies in terms of academic innovation. The contrast becomes more evident when we consider China’s performance – which has implemented a range of strategies to foster international partnerships with Western academic communities.

Practical implications/social implications
We contend that the demand for “de-Westernization” must go beyond a mere plea for increased numerical representation. The exclusion of perspectives or phenomena from developing regions hinders the progress of knowledge production itself. Once Social and Human Sciences traditionally occupy a peripheral position in terms of funding, it is as if Communication researchers based in the Global South were part of a “periphery of the periphery.”

Originality/value
The paper is relevant for enabling us to discuss Global South universities’ international insertion and the dynamics influencing the academic contributions of semi-peripheral communities. We also consider to what extent the SciVal and SJR metrics reinforce an academic rationale that upholds the mechanisms of neoliberal globalization and the standardization of the scholarly agenda.
Synthesis, molecular modeling, quantum chemical calculations and in silico drug profiling of the novel (4-phenylpiperazin-1-ium) hydrogenfumarate as a tyrosinase inhibitor
Authors: Jemai Mahdi , Issaoui Noureddine , Roisnel Thierry , Kazachenko Aleksandr S. , Marouani Houda , Al-Dossary Omar M. 
Published: December 2023

Abstract
The complexation between fumaric acid (FA) and 1-phenylpiperazine (1 PP) is a fruitful cooperation that allowed the preparation of a new organic crystal entitled (4-phenylpiperazin-1-ium) hydrogenfumarate denoted by 4PPHFUM, which is reported in the present manuscript. This new substance is created by the slow evaporation that occurs when 1-phenylpiperazine and fumaric acid are combined in a stoichiometric 1:1 ratio. The stacking of the crystal is provided by O–H⋯O, N–H⋯O and C–H⋯O hydrogen bonds, also supported by C–H⋯π interactions between the organic cations. The importance of these interactions in the formation of this new crystal is confirmed by the Hirshfeld surface analysis which showed that H-bonds and supramolecular C–H⋯π interactions account for about half of the non-covalent interactions existing in this compound. These non-covalent bonds that encompass the synthesis and design of this supramolecule have also been analyzed in detail using a quantum chemical computational study. Using the docking – based drug design strategy, we investigated the therapeutic effect of this cooperative outcome between fumaric acid and 1-phenylpiperazine to demonstrate the improved therapeutic property of this novel non-covalent compound as a tyrosinase inhibitor. 4PPHFUM was found to be a potent tyrosinase inhibitor with high interaction energy with its protein, higher than that of the most potent tyrosinase inhibitors (thiamidol, hydroquinone, resorcinol, hexylresorcinol and kojic acid).