bluuebunny/crossref_metadata_2025_split huggingface dataset:
Is it a coloboma or not? A new definition for isolated lens coloboma: focal zonular dysgenesis
Authors: Larivoir Nicole B. , Marinho Paula M. , Teixeira Ivan C. , De Figueiredo Gabriel B. , Fernandes Rodrigo A. B. , Freitas Lincoln L. 
Published: December 2023

Purpose:
Ocular coloboma is defined as a congenital malformation caused by defective closure of the fetal fissure, resulting in a notch in any structure. However, the entity known as “isolated lens coloboma” does not seem to have a similar etiological basis with other ocular colobomas. This congenital malformation can induce an important decrease of the visual acuity, and facectomy has an increased risk for intraoperative and postoperative complications. Better surgical planning could be achieved with an accurate definition of the diagnosis and pathophysiology of this lens abnormality, as the extent and mechanism of zonular disease will have a significant impact on the selection of the modality of intervention.

Methods:
Nine eyes of seven patients, who were diagnosed with “isolated lens coloboma” and underwent phacoemulsification and implant of intraocular lens (IOL), were studied (retrospective case series). The surgeries were performed by four different surgeons, according to their preferred technique, in the last 5 years.

Results:
There were no intraoperative complications. Two (22.22%) eyes presented postoperative complications, one of which was the IOL decentralization.

Conclusion:
Considering the ocular morphogenesis and the definition of coloboma, the ideal denomination for the congenital malformation traditionally known as isolated lens coloboma would be “focal zonular dysgenesis.” The best surgical approach, contemplating the pathophysiology, in addition to the cases described and review of literature, is discussed.
Surveillance of methicillin-resistant Staphylococcus aureus infections obtained from pus sample: A comparison of community- and hospital-acquired infections
Authors: Thakkar Jainy , Shah Prashant C. , Trivedi Niyati 
Published: December 2023

Abstract

Background:
Methicillin-resistant Staphylococcus aureus (MRSA) is one of the most common causes of healthcare-associated infections. Recently, the prevalence of community-associated MRSA (CA-MRSA) is increasing affecting individuals with no known risk factors or health-care exposure, blurring the differences between the two. With changing epidemiology of an organism having a natural tendency of fast-developing resistance, MRSA infections need active ongoing surveillance, for effective implementation of appropriate treatment and preventive strategies.

Patients and Methods:
This was a prospective, observational study conducted in various inpatient departments of a tertiary care teaching hospital in Gujarat, India. MRSA infections were classified as community-acquired-MRSA (CA-MRSA) and hospital-acquired MRSA (HA-MRSA) based on the US CDC 2010 definition. Clinical and epidemiological profile as well as antibiotic sensitivity was assessed in both the groups. An unpaired t-test or Fisher’s exact test was applied to find the difference between the two groups.

Results:
MRSA isolation rate was 1.42% (60/4212). Ninety percentage of the isolates were multidrug-resistant (MDR), with three being vancomycin-resistant/intermediate. The total duration of hospitalization, number of antimicrobials used after isolation, and duration of therapy were higher in HA-MRSA compared to the CA-MRSA group. The treatment outcome was successful in 86.6% of patients.

Conclusion:
There is an increasing prevalence of CA-MRSA in the community with the majority of isolates being MDR. These data are alarming and indicate an urgent need for the implementation of strategies directed toward the effective use of appropriate antimicrobials as well as the improvement of hygiene practices in the hospital as well as the community.
Molecular mechanisms of postoperative ileus following gastrointestinal surgery
Authors: Gong Wenbin , Fu Hangyu , Zhao Wei 
Published: December 2023

Abstract
Postoperative ileus (POI) is characterized by a transient cessation of gastrointestinal (GI) motility and is a common complication following surgery, especially GI surgery. The mechanism of POI is complex and multifactorial and is considered to be mainly related to sympathetic neural reflexes, activation of gut opioid receptors, and inflammatory reactions. Incision of the skin and muscle, as well as the opening of the peritoneal cavity cause a neurological reflex arc involving the spinal loop with afferent splanchnic nerves synapsing in the spinal cord, activating efferent traveling back to the gut, which constitutes the first phase of POI. Once the stimulation by intestinal manipulation, traction of the abdomen for laparotomy, and distension for laparoscopy have been completed, accompanied by abdominal closure, activation of these signal pathways will terminate. As the neurological phase subsides, numerous immune cell infiltration, including mast cells, monocytes, and macrophages, appear in the intestine, which promotes the secretion of pro-inflammatory molecules and the induction of intestinal inflammation. The resolution of inflammation is the last pathological phase of POI, which is mainly mediated by the macrophage polarization and vagal system. This review highlights the current knowledge of molecular mechanisms of POI after elective intestinal surgery, which may offer the possibility and direction for effective management and treatment plans to reduce the burden of POI.
Determining the need for a thoracoscopic approach to treat a giant hiatal hernia when abdominal access is poor
Authors: Pérez Lara Francisco Javier , Zubizarreta Jimenez Rogelio , Prieto-Puga Arjona Tatiana , Gutierrez Delgado Pilar , Hernández Carmona Juan Manuel , Hernández Gonzalez Jose Manuel , Pitarch Martinez Maria 
Published: December 2023

BACKGROUND
Giant hernias present a significant challenge for digestive surgeons. The approach taken (laparoscopic vs thoracoscopic) depends largely on the preferences and skills of each surgeon, although in most cases today the laparoscopic approach is preferred.
AIM
To determine whether patients presenting inadequate laparoscopic access to the intrathoracic hernial sac obtain poorer postoperative results than those with no such problem, in order to assess the need for a thoracoscopic approach.
METHODS
For the retrospective series of patients treated in our hospital for hiatal hernia (n = 112), we calculated the laparoscopic field of view and the working area accessible to surgical instruments, by means of preoperative imaging tests, to assess the likely outcome for cases inaccessible to laparoscopy.
RESULTS
Patients with giant hiatal hernias for whom a preoperative calculation suggested that the laparoscopic route would not access all areas of the intrathoracic sac presented higher rates of perioperative complications and recurrence during follow-up than those for whom laparoscopy was unimpeded. The difference was statistically significant. Moreover, the insertion of mesh did not improve results for the non-accessible group.
CONCLUSION
For patients with giant hiatal hernias, it is essential to conduct a preoperative evaluation of the angle of vision and the working area for surgery. When parts of the intrathoracic sac are inaccessible laparoscopically, the thoracoscopic approach should be considered.
Effects of remifentanil combined with propofol on hemodynamics and oxidative stress in patients undergoing resection of rectal carcinoma
Authors: Huang Jing , Tian Wen-Jun 
Published: December 2023

BACKGROUND
Rectal carcinoma (RC) treatment primarily involves laparoscopic surgery, which may induce significant hemodynamic changes and weaken immune function. Certain anesthetic approaches using opioid drugs (including remifentanil and sufentanil) pose risks, such as hypotension.
AIM
To determine the effects of remifentanil combined with propofol on hemodynamics and oxidative stress in patients undergoing RC resection.
METHODS
A total of 211 patients one hundred and four patients with RC treated at the First Affiliated Hospital of Dalian Medical University between November 2018 and November 2022 were retrospectively analyzed. Among them, the remifentanil group included 45 patients receiving remifentanil with propofol anesthesia and the sufentanil group included 59 patients receiving sufentanil with propofol anesthesia. Changes in the hemodynamic index, oxidative stress index, general data, consumption of remifentanil, and use of vasoactive drugs were compared. The incidences of adverse reactions were calculated.
RESULTS
The two groups did not significantly differ in terms of operation, anesthesia, and extubation times (P > 0.05). At 1 min after intubation, the sufentanil group showed a notably higher heart rate, systolic blood pressure (SBP), diastolic blood pressure, and mean arterial pressure (MAP) compared with the remifentanil group (P < 0.05), whereas the sufentanil group showed a notably higher SBP and MAP compared with the remifentanil group at 5 min after pneumoperitoneum (P < 0.05). Thirty minutes after surgery, the remifentanil group showed significantly lower plasma cortisol, noradrenaline, and glucose levels than the sufentanil group (P < 0.001). The remifentanil group consumed significantly less remifentanil than the sufentanil group (P < 0.05), and the adoption frequency of ephedrine was lower in the remifentanil group than that in the sufentanil group (P < 0.05). The incidence of hypotension was notably higher in the sufentanil group than that in the remifentanil group (P < 0.05).
CONCLUSION
Remifentanil combined with propofol can improve hemodynamics and relieve oxidative stress in patients undergoing RC resection.
Impact of hepatectomy and postoperative adjuvant transarterial chemoembolization on serum tumor markers and prognosis in intermediate-stage hepatocellular carcinoma
Authors: Hu Yi-Di , Zhang Hui , Tan Wei , Li Zhuo-Kai 
Published: December 2023

BACKGROUND
Primary hepatocellular carcinoma (HCC) is a common malignant tumour, and its early symptoms are often not obvious, resulting in many patients experiencing middle- to late-stage disease at the time of diagnosis. The optimal time for surgery is often missed for these patients, and those who do undergo surgery have unsatisfactory long-term outcomes and a high recurrence rate within five years. Therefore, postoperative follow-up treatments, such as transhepatic arterial chemoembolization (TACE), have become critical to improving survival and reducing recurrence rates.
AIM
To validate the prophylactic role of TACE after hepatic resection and to assess its impact on patient prognosis.
METHODS
This study investigated the efficacy of TACE in patients with intermediate-stage HCC after hepatectomy. When the post-treatment results of the observation group and the control group were compared, it was found that the inclusion of TACE significantly improved the clinical efficacy, reduced the levels of tumour markers and did not aggravate the damage to liver function. Thus, this may be an effective and comprehensive treatment strategy for patients with intermediate-stage HCC that helps to improve their quality of life and survival time.
RESULTS
When the baseline data were analysed, no statistical differences were found between the two groups in terms of gender, age, hepatitis B virus, cirrhosis, Child-Pugh grading, number of tumours, maximum tumour diameter and degree of tumour differentiation. The assessment of clinical efficacy showed that the post-treatment overall remission rate of the observation group was significantly higher than that of the control group. In terms of changes in tumour markers, the alpha-fetoprotein and carcinoembryonic antigen levels in the patients in the observation group decreased more significantly after treatment compared with those in the control group. When post-treatment changes in liver function indicators were analysed, no statistical differences were found in the total bilirubin, alanine aminotransferase and aspartate aminotransferase levels between the two groups.
CONCLUSION
In patients with intermediate-stage HCC, post-hepatectomy TACE significantly improved clinical outcomes, reduced tumour-marker levels and may have improved the prognosis by removing residual lesions. Thus, this may be an effective and comprehensive treatment strategy for patients with intermediate-stage HCC.
Successful treatment of invasive liver abscess syndrome caused by Klebsiella variicola with intracranial infection and septic shock: A case report
Authors: Zhang Pin-Jie , Lu Zhong-Hua , Cao Li-Jun , Chen Hu , Sun Yun 
Published: December 2023

BACKGROUND
Klebsiella variicola (K. variicola ) is a member of the Klebsiella genus and is often misidentiﬁed as Klebsiella pneumoniae . In this report, we present a rare case of invasive liver abscess caused by K. variicola .
CASE SUMMARY
We report a rare case of liver abscess due to K. variicola . A 57-year-old female patient presented with back pain for a month. She developed a high-grade fever associated with chills, and went into a coma and developed shock. The clinical examinations and tests after admission confirmed a diagnosis of primary liver abscess caused by K. variicola complicated by intracranial infection and septic shock. The patient successfully recovered following early percutaneous drainage of the abscess, prompt appropriate antibiotic administration, and timely open surgical drainage.
CONCLUSION
This is a case of successful treatment of invasive liver abscess syndrome caused by K. variicola , which has rarely been reported. The findings of this report point to the need for further study of this disease.
Assistive Learning Intelligence Navigator (ALIN) Dataset: Predicting Test Results from Learning Data
Authors: He Guijia , Huang Chengwei , Yang Steven , Lwin Kelvin , Ouh Eng Lieh , Ju Ran , Zhu Xiaoming 
Published: December 2023

Data mining techniques have garnered significant attention within the realm of education. In this paper, we present two public available datasets for adaptive learning and studied predicting algorithms for learning results. First, we present a student dataset characterized by its size and distinctive attributes. This dataset encompasses various task-related topics interconnected through a learning pathway, thereby enabling researchers to delve into the data from novel perspectives. Moreover, it encompasses extensive longitudinal student behavioral data, a rarity that adds substantial value. Spanning the years from 2010 to 2021, our dataset comprises a cohort of 7933 students, 64,344 test scores, and 183,390 behavior records, solidifying its status as a valuable resource for educational research. Second, we proposed methods for predicting the testing results with and without practice tests. Novel learning features are constructed and various machine learning algorithms are compared. Finally, in our experiments, we achieved precision rate of 0.703 and recall rate of 0.734 in the prediction of students’ test outcomes based on behavioral learning data. The robustness of our dataset makes it well-suited for examining the connection between student behavior and academic performance, developing tailored learning recommendations, and exploring diverse research avenues.

Received: 8 September 2023 | Revised: 27 November 2023 | Accepted: 25 December 2023

Conflicts of Interest
The authors declare that they have no conflicts of interest to this work.

Data Availability Statement
The data that support the findings of this study are openly available in [Google] at https://sites.google.com/site/assistmentsdata/home/2009-2010-assistment-data, in [Github] at https://github.com/AdaptiveLearning2022/DataSetALIN2022, and in [IEEE Dataport] at https://ieee-dataport.org/documents/alin-open-dataset-math-adaptive-learning.
Contralateral eye comparison of the efficacy and safety of two artificial tear formulations for corneal subbasal nerve fiber regeneration after photorefractive keratectomy
Authors: Md Rejab Noor Shazana , Hilmi Mohd Radzi , Mohd Kamal Khairidzan , Wolffsohn James S 
Published: December 2023

Background: Currently, artificial tears (ATs) are the first-line agents for managing dry eye disease (DED). This study compared the efficacy and safety of two different AT formulations, Systane® Hydration (SH) and Systane® Ultra (SU), on symptoms of DED and regeneration of the subbasal corneal nerve fiber length (CNFL) in photorefractive keratectomy (PRK)-treated eyes.
Methods: This prospective contralateral comparative study recruited myopic eyes scheduled for PRK, and either SH or SU were administered for up to 3 months postoperatively. All participants underwent a standard comprehensive preoperative ophthalmological examination, in vivo confocal microscopy to evaluate the subbasal CNFL, and completed Ocular Surface Disease Index (OSDI) questionnaire for assessing dry eye symptoms. Image analysis software was used to calculate the subbasal CNFL (micrometer/mm2). Assessments were repeated at the 1- and 3-month follow-up visits. Pre- and postoperative subbasal CNFL and OSDI scores were compared to determine inter- and intra-group differences.
Results: Fifty eyes of 25 participants were included in this study. The mean (standard deviation) age of the participants was 22.7 (3.8) years. The OSDI scores for both groups increased significantly at 1 month (both P<0.05), followed by a decrease at 3 months to values comparable to the preoperative scores (both P>0.05). Although OSDI scores were comparable at baseline and at the 1-month postoperative visit (both P>0.05), the SU-treated eyes had a significantly better OSDI score at the 3-month visit (P<0.05), despite being clinically insignificant. Preoperative subbasal CNFL differed significantly between the groups (P=0.001), yet the mean values at both postoperative visits were comparable (both P>0.05). In both groups, subbasal CNFL was significantly reduced at 1 month, followed by a significant increase at the 3-month postoperative visit compared to baseline (all P<0.05). No treatment-related complications were observed at the end of the study period.
Conclusions: No significant difference was found between the preoperative and 3-month postoperative OSDI scores in the SH- or SU-treated eyes. Subbasal CNFL regeneration indicated a positive effect of both ATs, with a longer mean CNFL noted in the SH-treated eyes at the final visit. This suggests that SH may be a better option for improving corneal reinnervation after PRK. These observations must be verified in further trials with longer follow-up periods and larger sample sizes.
Komunikasi Antarpribadi dalam Konsep Tabayyun antara Nabi Musa dengan Nabi Khidir Dalam Alquran
Authors: Wahyu Armanda  
Published: December 2023

Tujuan penelitian ini adalah untuk mengetahui komunikasi antarpribadi dalam konsep tabayyun antara Nabi Musa dengan Nabi Khidir dalam Alquran. Dalam penelitian ini menggunakan jenis penelitian kualitatif dalam paradigma bahasa dengan pendekatan kepustakaan library research yaitu peneliti menggunakan tafsir metode Tahlili dimana peneliti menggunakan jenis penelitian analisis deskriptif yang sifatnya menjelaskan. Sumber data yang digunakan adalah Alquran, Tafsir Ibnu Katsir, Tafsir Abdurrahman bin Nashir as Sa’di, Buku-buku komunikasi, serta Literatur-literatur yang dapat dijadikan sumber referensi pada penelitian ini. Teknik pengumpulan data menggunakan metode Studi dokumentasi yaitu mengumpulkan ayat-ayat Alquran yang berkaitan dengan penelitian, kemudian menafsirkan nya, sesuai dengan pemahaman Ulama Tafsir, mencari munasabah antara ayat pertama dengan ayat berikutnya serta menganalisis ayat tersebut dan mengaitkannya dengan komunikasi antarpribadi. Teori yang digunakan adalah uncertainly reduction theory. Hasil penelitian: komunikasi yang terjadi diantara keduanya kurang efektif, karena terdapat hambatan komunikasi yang menyebabkan terjadinya kesalahpahaman antara keduanya. Penyebab terjadinya adalah karena tidak memiliki kesamaan dalam pengetahuan, tidak teliti dalam menyikapi suatu masalah, dan tidak bersabar dalam ketaatan terhadap peraturan yang telah disepakati
A APLICABILIDADE DA LEI 11.340/06 NOS CASOS EM QUE O (A) AGRESSOR (A) É ADOLESCENTE
Authors: Oliveira Marlene Gomes de Souza 
Published: December 2023

O presente trabalho vem acerca-se na análise da Lei 11.340/2006, também conhecida como “Lei Maria da Penha”, bem como da Lei 8.069/1990, o Estatuto da Criança e do Adolescente. O objetivo primordial foi analisar qual das leis supracitadas pode/deve ser aplicada no caso concreto de violência doméstica e/ou familiar contra mulher perpetrada por adolescente. Deste modo, buscou-se compreender a aplicação de cada lei específica, o procedimento adequado e correto quando da prática da referida violência. O trabalho verificou que a Lei Maria da Penha e o ECA coexistem em diversos momentos e em aspectos distintos em cada legislação. Constatou-se que em desfavor ao adolescente, quando em conflito com a lei pela prática de violência doméstico-familiar contra mulher, pode ser aplicável, na maioria das vezes. Além disso, abordou-se o estudo do histórico da violência doméstica e familiar contra o sexo feminino, comparando o período anterior e posterior à Lei 11.340/06, bem como a sua aplicação subsidiária ou não ao ECA, auferindo descobrir se utilizar-se-á a lei específica e mais recente ao problema, ou àquela que trata exclusivamente dos direitos, deveres e garantias dos adolescentes.
USO DA ESTIMULAÇÃO SENSORIAL NA REABILITAÇÃO DE RECÉM-NASCIDOS COM LESÃO CEREBRAL
Authors: Silva Larissa Nascimento Antunes da , Bonfim Júnior Cristiano Lins , Dantas Ediana Alves , Andrade Kelvin Borges de , Silva Verônica Sales da 
Published: December 2023

A estimulação sensorial como método diagnóstico e terapêutico precoce para prevenir as sequelas de lesões cerebrais em recém-nascidos foi desenvolvida na Hungria por Katona. Baseia-se no conceito de plasticidade do sistema nervoso jovem e considera a repetição de determinadas manobras terapêuticas que se baseiam nos padrões sensório-motores do neurodesenvolvimento, específicos do ser humano e muito semelhantes às atividades motoras dos adultos. Essas funções sensório-motoras são ativadas pela gravidade através do sistema vestibular e estão sob o controle dos gânglios da base, do sistema reticular e do paleocerebelo. O presente estudo tem como objetivo conhecer a utilidade clínica diagnóstica e terapêutica da estimulação sensorial como método de prevenção de sequelas de lesão cerebral em neonatos e lactentes com fatores de risco para danos neurológicos. Metodologicamente utilizou-se a revisão de literatura ou bibliográfica que tem como finalidade realizar pesquisas nas bases de dados e revistas científicas sobre o assunto em questão. Os resultados em relação a prevalência de bases de dados nos estudos da amostra final de 13 artigos. Conclui-se que a estimulação sensorial um método eminentemente clínico, a sua prática oferece potencial não só terapêutico, mas também de ser uma ferramenta muito valiosa no diagnóstico pediátrico e neonatológico.