bluuebunny/crossref_metadata_2025_split huggingface dataset:
Adoption of Emergency Department–Initiated Buprenorphine for Patients With Opioid Use Disorder
Authors: Gao Evangeline , Melnick Edward R. , Paek Hyung , Nath Bidisha , Taylor R. Andrew , Loza Andrew J. 
Published: November 2023

ImportanceEmergency department (ED) initiation of buprenorphine is safe and effective but underutilized in practice. Understanding the factors affecting adoption of this practice could inform more effective interventions.ObjectiveTo quantify the factors, including social contagion, associated with the adoption of the practice of ED initiation of buprenorphine for patients with opioid use disorder.Design, Setting, and ParticipantsThis is a secondary analysis of the EMBED (Emergency Department-Initiated Buprenorphine For Opioid Use Disorder) trial, a multicentered, cluster randomized trial of a clinical decision support intervention targeting ED initiation of buprenorphine. The trial occurred from November 2019 to May 2021. The study was conducted at ED clusters across health care systems from the northeast, southeast, and western regions of the US and included attending physicians, resident physicians, and advanced practice practitioners. Data analysis was performed from August 2022 to June 2023.ExposuresThis analysis included both the intervention and nonintervention groups of the EMBED trial. Graph methods were used to construct the network of clinicians who shared in the care of patients for whom buprenorphine was initiated during the trial before initiating the practice themselves, termed exposure.Main Outcomes and MeasuresCox proportional hazard modeling with time-dependent covariates was performed to assess the association of the number of these exposures with self-adoption of the practice of ED initiation of buprenorphine while adjusting for clinician role, health care system, and intervention site status.ResultsA total of 1026 unique clinicians in 18 ED clusters across 5 health care systems were included. Analysis showed associations of the cumulative number of exposures to others initiating buprenorphine with the self-practice of buprenorphine initiation. This increased in a dose-dependent manner (1 exposure: hazard ratio [HR], 1.31; 95% CI, 1.16-1.48; 5 exposures: HR, 2.85; 95% CI, 1.66-4.89; 10 exposures: HR, 3.55; 95% CI, 1.47-8.58). Intervention site status was associated with practice adoption (HR, 1.50; 95% CI, 1.04-2.18). Health care system and clinician role were also associated with practice adoption.Conclusions and RelevanceIn this secondary analysis of a multicenter, cluster randomized trial of a clinical decision support tool for buprenorphine initiation, the number of exposures to ED initiation of buprenorphine and the trial intervention were associated with uptake of ED initiation of buprenorphine. Although systems-level approaches are necessary to increase the rate of buprenorphine initiation, individual clinicians may change practice of those around them.Trial RegistrationClinicalTrials.gov Identifier: NCT03658642
The golden native drone fly (Eristalinus punctulatus) is an effective hybrid carrot pollinator that lives within Australian crop agroecosystems
Authors: Davis Abby E. , Schmidt Lena A. , Santos Karen C. B. S. , Martin Lucie , Harrington Samantha , Rocchetti Maurizio , Hocking Brad , Wright Derek , Spurr Cameron , Cook David , Rader Romina 
Published: November 2023

Abstract

Native insect flower visitors can be important contributors to crop pollination, yet little is known of their pollination abilities and the resources (habitat) they need to be supported within crop agroecosystems.

Here, we compared the abundance and pollination abilities of the golden drone fly (Eristalinus punctulatus) to the European honey bee (Apis mellifera) in hybrid carrot crop fields known to produce variable seed yields in regional New South Wales, Australia. We further observed the egg‐laying behaviours of female golden drone flies at a commercial berry orchard to provide insight into the habitat needs of this species.

In hybrid carrot crop fields, golden drone flies were far less abundant flower visitors than European honey bees; however, these flies deposited more carrot pollen grains on average (8.21 ± 3.04 SE) onto carrot flowers than European honey bees (3.45 ± 1.06 SE). Both insects also deposited pollen onto a similar number of carrot flowers (pollinated) per visit (about 2 out of 18).

Golden drone flies were observed laying eggs within masses of discarded red raspberry plant roots and soil (root balls) at a commercial berry orchard. The natural habitat utilised by these flies, as well as their egg‐laying behaviours, were described for the first time.

Our results indicate that golden drone flies are effective pollinators of hybrid carrot crop plants. The habitat that these flies utilised to lay eggs (discarded plants and water) is cheap and commonly found in crop agroecosystems. Therefore, we recommend placing this low‐cost habitat within, or nearby, crop fields as a potential management practice to support the lifecycle needs of golden drone flies and other non‐bee pollinators.
Self‐Reliant Nanomedicine with Long‐Lasting Glutathione Depletion Ability Disrupts Adaptive Redox Homeostasis and Suppresses Cancer Stem Cells
Authors: Xiong Yuxuan , Yong Zhengtao , Li Shiyou , Wang Qiang , Chen Xiang , Zhang Zhijie , Zhao Qingfu , Deng Qingyuan , Yang Xiangliang , Li Zifu 
Published: November 2023

AbstractBulk cancer cells and cancer stem cells (CSCs) harbor efficient and adaptive redox systems to help them resist oxidative insults arising from diverse therapeutic modalities. Herein, a tumor microenvironment (TME)‐activatable nano‐modulator capable of disrupting adaptive redox homeostasis, prepared by integrating FDA‐approved xCT inhibitor sulfasalazine (SSZ) into pH‐responsive hydroxyethyl starch‐doxorubicin conjugate stabilized copper peroxide nanoparticles (HSCPs) is reported. Compared to poly(vinylpyrrolidone) (PVP)‐stabilized copper peroxide nanoparticles, HSCPs exhibit superior physiological stability, longer circulation half‐life, and higher tumor enrichment. Under an acidic TME, the active components inside HSCPs are productively released along with the disintegration of HSCPs. The specifically generated hydrogen peroxide (H2O2) from copper peroxide nanoparticles furnishes a constant power source for copper‐mediated hydroxyl radical (•OH) production, serving as a wealthy supplier for oxidative stress. Meanwhile, the tumor‐specific release of Cu2+ and SSZ can induce long‐lasting glutathione (GSH) depletion via copper‐mediated self‐cycling valence transitions and SSZ‐blocked GSH biosynthesis, thereby reducing the offsetting action of the antioxidant GSH against oxidative stress. As a result, this sustained oxidative stress potently restrains the growth of aggressive orthotopic breast tumors while suppressing pulmonary metastasis by eradicating CSC populations. The reported smart nanomedicine provides a new paradigm for redox imbalance‐triggered cancer therapy.
Time Dependence of Kinetic Unmixing and Kinetic Decomposition of a Perovskite ABO3 under Applied Voltage—A Case Study for BaTiO3
Authors: Ader Christiane , Chun Jakyu , Yoo Han‐Ill , Martin Manfred 
Published: November 2023

AbstractIn multinary oxides such as perovskites ABO3, an applied voltage causes charged mobile species (ions, electrons) to move according to their electrochemical mobilities. For different electrochemical mobilities of the cations kinetic unmixing takes place, and after some time even kinetic decomposition may occur. Both kinetic effects are detrimental to the functional application of the oxide, for example, in electrochemical cells or in multilayer ceramic capacitors. Thus far, kinetic unmixing and decomposition are analyzed by treating ABO3 only as a quasi‐binary mixture of AO and BO2, acceptors are not considered, and only the steady state of kinetic unmixing is investigated, allowing no prediction of the lifetime until kinetic decomposition. Here, ABO3 is treated as a really ternary system with defects in all three sublattices and with electronic defects. The complete set of transport equations is derived, and the moving boundary problem with six mobile species is solved numerically to investigate the time‐dependence of kinetic unmixing. As a case study, BaTiO3 is used which has various applications as a functional oxide. The simulations yield the kinetic decomposition voltage of the oxide, below which no kinetic decomposition occurs. For voltages larger than this critical value the lifetime of the oxide until kinetic decomposition is predicted.
Potassium‐Based Dual‐Ion Batteries Operating at −60 °C Enabled By Co‐Intercalation Anode Chemistry
Authors: Que Lanfang , Wu Jihuai , Lan Zhang , Xie Yiming , Yu Fuda , Wang Zhenbo , Meng Jiashen , Zhang Xingcai 
Published: November 2023

AbstractBattery performance at subzero is restricted by sluggish interfacial kinetics. To resolve this issue, potassium‐based dual‐ion batteries (K‐DIBs) based on the polytriphenylamine (PTPAn) cathode with anion storage chemistry and the hydrogen titanate (HTO) anode with K+/solvent co‐intercalation mechanism are constructed. Both the PTPAn cathode and the HTO anode do not undergo the desolvation process, which can effectively accelerate the interfacial kinetics at subzero. As revealed by theoretical calculations and experimental analysis, the strong K+/solvent binding energy in the dilute electrolyte, the charge shielding effect of the crystal water, and the uniform SEI layer with high content of the flexible organic species synergically promote HTO to undergo K+/solvent co‐intercalation behavior. The special co‐intercalation mechanism and anion storage chemistry enable HTO||PTPAn K‐DIBs with superior rate performance and cycle durability, maintaining a capacity retention of 94.1% after 6000 cycles at −40 °C and 91% after 1000 cycles at −60 °C. These results provide a step forward for achieving high‐performance energy storage devices at low temperatures.
Highly‐Adaptable Optothermal Nanotweezers for Trapping, Sorting, and Assembling across Diverse Nanoparticles
Authors: Chen Jiajie , Zhou Jianxing , Peng Yuhang , Dai Xiaoqi , Tan Yan , Zhong Yili , Li Tianzhong , Zou Yanhua , Hu Rui , Cui Ximin , Ho Ho‐Pui , Gao Bruce Zhi , Zhang Han , Chen Yu , Wang Meiting , Zhang Xueji , Qu Junle , Shao Yonghong 
Published: November 2023

AbstractOptical manipulation of various kinds of nanoparticles is vital in biomedical engineering. However, classical optical approaches demand higher laser power and are constrained by diffraction limits, necessitating tailored trapping schemes for specific nanoparticles. They lack a universal and biocompatible tool to manipulate nanoparticles of diverse sizes, charges, and materials. Through precise modulation of diffusiophoresis and thermo‐osmotic flows in the boundary layer of an optothermal‐responsive gold film, highly adaptable optothermal nanotweezers (HAONTs) capable of manipulating a single nanoparticle as small as sub‐10 nm are designed. Additionally, a novel optothermal doughnut‐shaped vortex (DSV) trapping strategy is introduced, enabling a new mode of physical interaction between cells and nanoparticles. Furthermore, this versatile approach allows for the manipulation of nanoparticles in organic, inorganic, and biological forms. It also offers versatile function modes such as trapping, sorting, and assembling of nanoparticles. It is believed that this approach holds the potential to be a valuable tool in fields such as synthetic biology, optofluidics, nanophotonics, and colloidal science.
A‐site Cation Exchange Enables a High‐performance CsPbBr3 Photodetector for Laser Eavesdropping Systems
Authors: Zhang Jianqiang , Pan Xiyan , Sun Jie , Zhou Hai , Zhang Guoping , Ding Liming 
Published: November 2023

AbstractOwing to the absence of organic cations, all‐inorganic perovskite exhibits superior thermal and irradiation stability compared to organic‐inorganic perovskite. However, it is difficult for the traditional solution method to produce pinhole‐free and phase‐pure all‐inorganic perovskite films, which hinders its application. Here, a method of in situ A‐site cation exchange to synthesize CsPbBr3 films is introduced. The MAPbBr3 films are treated with CsAc solution to initiate cation exchange, where the intermediate product MAAc plays a crucial role in guiding grain growth during evaporation, resulting in the production of pinhole‐free and phase‐pure CsPbBr3 films. The self‐powered photodetector, based on compact and pinhole‐free CsPbBr3 film, exhibits excellent performance with an LDR of 126.7 dB, a detectivity of 1.1 × 1013 Jones, and a rise/decay time of 2.9/25.1 µs. Furthermore, the photodetector maintains over 90% of its original performance after a 2500 s irradiation test and a 30‐day air exposure test. Benefiting from the exceptional device performance and stability, the photodetector proves to be a valuable component in the laser eavesdropping system.
YAP Signaling Regulates the Cellular Uptake and Therapeutic Effect of Nanoparticles
Authors: Cassani Marco , Fernandes Soraia , Oliver‐De La Cruz Jorge , Durikova Helena , Vrbsky Jan , Patočka Marek , Hegrova Veronika , Klimovic Simon , Pribyl Jan , Debellis Doriana , Skladal Petr , Cavalieri Francesca , Caruso Frank , Forte Giancarlo 
Published: November 2023

AbstractInteractions between living cells and nanoparticles are extensively studied to enhance the delivery of therapeutics. Nanoparticles size, shape, stiffness, and surface charge are regarded as the main features able to control the fate of cell‐nanoparticle interactions. However, the clinical translation of nanotherapies has so far been limited, and there is a need to better understand the biology of cell‐nanoparticle interactions. This study investigates the role of cellular mechanosensitive components in cell‐nanoparticle interactions. It is demonstrated that the genetic and pharmacologic inhibition of yes‐associated protein (YAP), a key component of cancer cell mechanosensing apparatus and Hippo pathway effector, improves nanoparticle internalization in triple‐negative breast cancer cells regardless of nanoparticle properties or substrate characteristics. This process occurs through YAP‐dependent regulation of endocytic pathways, cell mechanics, and membrane organization. Hence, the study proposes targeting YAP may sensitize triple‐negative breast cancer cells to chemotherapy and increase the selectivity of nanotherapy.
Trace Amount of Nitrilotriacetate Induced Electrolyte Evolution and Textured Surface for Stable Zn Anode
Authors: Jiao Zhaoyang , Cai Xinxin , Wang Xiaoxu , Li Yiran , Bie Zhe , Song Weixing 
Published: November 2023

AbstractThe growth of dendrites and the hydrogen evolution reaction pose significant challenges to the development of Zn metal aqueous batteries as a promising solution for energy storage. Herein, trisodium nitrilotriacetate (Na3NTA) as an electrolyte additive is shown to improve the reversibility of the zinc plating–stripping process. NTA3− anions possess the potential not only to substitute water molecules in the solvation sheath of Zn2+ ions but also to construct a zincophilic electrolyte/Zn anode interface and suppress the activity of water molecules for stabilizing the Zn anode. The introduction of Na3NTA can effectively suppress side reactions arising from active water decomposition and simultaneously lead to the formation of a well‐defined (002) texture structure. As a result, a Zn||Zn symmetric cell with a modified electrolyte demonstrates a lifespan of up to 3000 h at a cutoff capacity of 1 mA h cm−2. Furthermore, a Zn||V2O5 full cell exhibits an enhanced capacity retention of 83.2% even after undergoing 8000 cycles. No noticeable dendrites are observed even after long cycles in both symmetric and full cells. Due to the cost‐effective material and ease of fabrication of the Na3NTA additive, this electrolyte strategy may promote the industrial application of aqueous zinc ion batteries.
Rearranging fluorescence‐magneto spatiality for “win‐win” dual functions to enhance point‐of‐care diagnosis
Authors: Su Yu , Chen Xirui , Huang Huan , Wu Yuhao , Shen Xuan‐ang , Lin Xiangkai , Sun Kun , Fan Xiao‐Yong , Huang Xiaolin , Xiong Yonghua 
Published: November 2023

AbstractFluorescent‐magneto nanoemitters have gained considerable attention for their applications in mechanical controlling‐assisted optical signaling. However, the incompatibility between magnetic and fluorescent components often leads to functional limitations in traditional magneto@fluorescence nanostructure. Herein, we introduce a new compact‐discrete spatial arrangement on a “fluorescence@magneto” core–shell nanostructure consisting of a close‐packed aggregation‐induced emission luminogen (AIEgen) core and a discrete magnetic shell. This structural design effectively eliminates the optical and magnetic interferences between the dual components by facilitating AIEgens loading in core region and reducing the magnetic feeding amount through effective exposure of the magnetic units. Thereby, the resulting magneto‐AIEgen nanoparticle (MANP) demonstrates “win‐win” performances: (i) high fluorescent intensity contributed by AIEgens stacking‐enhanced photoluminescence and reduced photons loss from the meager magnetic shell; (ii) marked magnetic activity due to magneto extraposition‐minimized magnetic shielding. Accordingly, the dual functions‐retained MANP provides a proof of concept for construction of an immunochromatographic sensing platform, where it enables bright fluorescent labeling after magnetically enriching and separating procalcitonin and lipoarabinomannan in clinical human serum and urine, respectively, for the clinical diagnosis of bacterial infections‐caused inflammation and tuberculosis. This study not only inspires the rational design of magnetic‐fluorescent nanoemitter but also highlights promising potential in magneto‐assisted point‐of‐care test and biomedicine applications.
Air filtration performance of nanofiber membranes with different morphologies produced by green electrospinning
Authors: Ángel‐Gómez Sara , Berger Simon , Niessner Jennifer , Álvarez‐Láinez Mónica Lucía 
Published: November 2023

AbstractTo further target product development with low environmental impact, an integral green electrospinning (G‐ES) approach has been adopted through the simultaneous application of various strategies, such as the use of biopolymers, reduction of energy use to avoid melting temperatures, and selection of non‐toxic solvents and surfactants. Green solubility spinnability maps for cellulose acetate (CA), poly ε‐caprolactone (PCL), and polyvinyl alcohol (PVA) are presented. Green electrospinning (G‐ES) allows the production of new morphologies for CA and PCL nanofiber membranes. In this work, CA exhibits a ribbon‐like morphology, PCL shows a honeycomb‐like morphology and PVA cylindrical fibers. Membrane morphologies are compared with filtration efficiency (FE) for particle size of 1.0 μm and quality factor (QF) at a volumetric flux of 27.63 cm−1. For CA is between 83% and 96% and high QF = 0.31–0.38 Pa−1, PCL is 92% and 99% and high QF = 0.28–0.21 Pa−1 and for PVA between 96% and 99% and high QF = 0.14–0.08 Pa−1. These results suggest that the hierarchical nanofiber structure improves filtration performance because of the reduction in pressure drop and increase in PM interception. CA ribbon‐like fibers favored air filtration performance, followed by PCL honeycomb‐like fibers.
The concept of cumulative deliberation: Linking systemic approaches to healthier normativity in assessing opinion formation in online discussions
Authors: Bodrunova Svetlana S. 
Published: November 2023

AbstractOnline opinion formation has received much scholarly attention since the mass proliferation of social networks. Inter alia, online opinions have been viewed as a new part of public deliberation. However, the pre‐Internet era's vision on deliberation imposes extremely high demands on users as deliberators. We argue that opinion formation online neither pursues the goals nor follows the rules of institutionalized consensus‐oriented round‐table deliberative processes. Moreover, the growing academic evidence shows that opinion formation online is predominantly cumulative, not deliberative in nature. Thus, we introduce the concept of cumulative deliberation as an alternative and addition to classic institutional deliberation and argue that it describes opinion formation online more precisely. Importantly, it allows for two crucial additions to the deliberation theory, which are the use of systemic approaches to measuring and predicting public opinion and new normativity that sees a user as an initially neutral discussion unit. It also allows for healthier distinction between “natural” user communication and intentional counter‐deliberative distortions in online communication, like computational propaganda or cyberbullying. We end up with suggesting a research agenda on cumulative deliberation.
Peptide ligands targeting the vesicular stomatitis virus G (VSV‐G) protein for the affinity purification of lentivirus particles
Authors: Barbieri Eduardo , Mollica Gina N. , Moore Brandyn D. , Sripada Sobhana A. , Shastry Shriarjun , Kilgore Ryan E. , Loudermilk Casee M. , Whitacre Zachary H. , Kilgour Katie M. , Wuestenhagen Elena , Aldinger Annika , Graalfs Heiner , Rammo Oliver , Schulte Michael M. , Johnson Thomas F. , Daniele Michael A. , Menegatti Stefano 
Published: November 2023

AbstractThe recent uptick in the approval of ex vivo cell therapies highlights the relevance of lentivirus (LV) as an enabling viral vector of modern medicine. As labile biologics, however, LVs pose critical challenges to industrial biomanufacturing. In particular, LV purification—currently reliant on filtration and anion‐exchange or size‐exclusion chromatography—suffers from long process times and low yield of transducing particles, which translate into high waiting time and cost to patients. Seeking to improve LV downstream processing, this study introduces peptides targeting the enveloped protein Vesicular stomatitis virus G (VSV‐G) to serve as affinity ligands for the chromatographic purification of LV particles. An ensemble of candidate ligands was initially discovered by implementing a dual‐fluorescence screening technology and a targeted in silico approach designed to identify sequences with high selectivity and tunable affinity. The selected peptides were conjugated on Poros resin and their LV binding‐and‐release performance was optimized by adjusting the flow rate, composition, and pH of the chromatographic buffers. Ligands GKEAAFAA and SRAFVGDADRD were selected for their high product yield (50%–60% of viral genomes; 40%–50% of HT1080 cell‐transducing particles) upon elution in PIPES buffer with 0.65 M NaCl at pH 7.4. The peptide‐based adsorbents also presented remarkable values of binding capacity (up to 3·109 TU per mL of resin, or 5·1011 vp per mL of resin, at the residence time of 1 min) and clearance of host cell proteins (up to a 220‐fold reduction of HEK293 HCPs). Additionally, GKEAAFAA demonstrated high resistance to caustic cleaning‐in‐place (0.5 M NaOH, 30 min) with no observable loss in product yield and quality.