bluuebunny/crossref_metadata_2025_split huggingface dataset:
Clinical and biological relevance of glial fibrillary acidic protein in Alzheimer’s disease
Authors: Yang Zhengshi , Sreenivasan Karthik , Toledano Strom Erin N. , Osse Amanda M. Leisgang , Pasia Lorenzo Gabriel , Cosme Celica Glenn , Mugosa Maya Rae N. , Chevalier Emma Léa , Ritter Aaron , Miller Justin B. , Cordes Dietmar , Cummings Jeffrey L. , Kinney Jefferson W. 
Published: November 2023

Abstract
Introduction
There is a tremendous need for identifying reliable blood-based biomarkers for Alzheimer’s disease (AD) that are tied to the biological ATN (amyloid, tau and neurodegeneration) framework as well as clinical assessment and progression.

Methods
One hundred forty-four elderly participants underwent 18F-AV45 positron emission tomography (PET) scan, structural magnetic resonance imaging (MRI) scan, and blood sample collection. The composite standardized uptake value ratio (SUVR) was derived from 18F-AV45 PET to assess brain amyloid burden, and the hippocampal volume was determined from structural MRI scans. Plasma glial fibrillary acidic protein (GFAP), phosphorylated tau-181 (ptau-181), and neurofilament light (NfL) measured by single molecular array (SIMOA) technology were assessed with respect to ATN framework, genetic risk factor, age, clinical assessment, and future functional decline among the participants.

Results
Among the three plasma markers, GFAP best discriminated participants stratified by clinical diagnosis and brain amyloid status. Age was strongly associated with NfL, followed by GFAP and ptau-181 at much weaker extent. Brain amyloid was strongly associated with plasma GFAP and ptau-181 and to a lesser extent with plasma NfL. Moderate association was observed between plasma markers. Hippocampal volume was weakly associated with all three markers. Elevated GFAP and ptau-181 were associated with worse cognition, and plasma GFAP was the most predictive of future functional decline. Combining GFAP and ptau-181 together was the best model to predict brain amyloid status across all participants (AUC = 0.86) or within cognitively impaired participants (AUC = 0.93); adding NfL as an additional predictor only had a marginal improvement.

Conclusion
Our findings indicate that GFAP is of potential clinical utility in screening amyloid pathology and predicting future cognitive decline. GFAP, NfL, and ptau-181 were moderately associated with each other, with discrepant relevance to age, sex, and AD genetic risk, suggesting their relevant but differential roles for AD assessment. The combination of GFAP with ptau-181 provides an accurate model to predict brain amyloid status, with the superior performance of GFAP over ptau-181 when the prediction is limited to cognitively impaired participants.
Mycosis fungoides with spongiosis: a case report
Authors: Kashabano Jesse Jonathan , Rugengamazi Eulade , Matiku Subira Bhoke , Mruma Rashid Mussa , Lugina Emmanuel L. 
Published: November 2023

Abstract
Background
Mycosis fungoides (MF) is the most common form of cutaneous T-cell lymphoma (CTCL). CTCL are an uncommon, heterogeneous group of non-Hodgkin lymphomas (NHLs) of T- and B-cell origin where the skin is the primary organ of involvement. It is characterized by malignant CD4+ T-cells infiltrating the skin and other organs, leading to progressive skin and systemic involvement. Histopathologically, MF is characterized by atypical lymphocytes demonstrating epidermotropism without spongiosis. Spongiosis is the histological hallmark of intercellular epidermal edema, viewed as clear spaces within the epidermis, and is very common in benign inflammatory dermatoses. Very few studies have reported MF in sub-Saharan Africa (SSA). We are reporting a case of MF with a rare presentation of spongiosis treated successfully with a low dose total skin electron beam therapy (TSEBT) followed by maintenance therapy of low dose Methotrexate (MT) at the Ocean Road Cancer Institute (ORCI) in Tanzania. This is the first case of MF to be managed with low-dose TSEBT in Tanzania. The authors wish to create awareness of the disease among physicians and pathologists and expand on the data paucity in SSA.

Case description
We are reporting a case of a 31-year-old male of African origin who self-referred to our oncology center with a 4-year history of skin rashes throughout the body, which was unresponsive to topical steroid treatment. The biopsy was taken, and the patient was diagnosed with MF CD 3 positive with spongiosis. The patient was treated with radiotherapy, whereby he received low dose total skin electron beam therapy (TSEBT) 12 Gy in 3 fractions at a daily dose of 4 Gy, followed by maintenance therapy of low dose Methotrexate and attained an excellent therapeutic response.

Conclusion
Spongiosis is an infrequent presentation of MF. Low-dose TSEBT provides reliable and rapid reduction of disease burden in patients with MF, which could be administered safely multiple times during a patient's disease with an acceptable toxicity profile. Lack of tendency to perform skin biopsies and cost constraints in assessing multiple immunophenotypic markers lead to missing the diagnosis. Diagnosis and treatment of MF in resource-limited countries is challenging.
Evaluating the value of 18F-PSMA-1007 PET/CT in the detection and identification of prostate cancer using histopathology as the standard
Authors: Luo Liang , Zheng Anqi , Chang Ruxi , Li Yunxuan , Gao Jungang , Wang Zhuonan , Duan Xiaoyi 
Published: November 2023

Abstract
Background
Prostate-specific membrane antigen (PSMA) PET/CT is a highly regarded radionuclide imaging modality for prostate cancer (PCa). This study aimed to evaluate the diagnostic performance of 18F-PSMA-1007 PET/CT in detecting intraprostatic lesions of PCa using radical prostatectomy (RP) specimens as a reference standard and to establish an optimal maximum standardized uptake value (SUVmax) cutoff for distinguishing between PCa and non-PCa lesions.

Methods
We retrospectively collected 117 patients who underwent 18F-PSMA-1007 PET/CT before RP. The uptake of the index tumor and contralateral non-PCa lesion was assessed. Histopathology of RP specimens was used as the gold standard. Kappa test was used to evaluate the consistency of preoperative PSMA PET/CT staging and postoperative pathological staging. Finally, an SUVmax cutoff value was identified by receiver operating characteristic (ROC) curve analysis to distinguish PCa lesions from non-PCa lesions. A prospective cohort including 76 patients was used to validate the results.

Results
The detection rate of 18F-PSMA-1007 PET/CT for prostate cancer was 96.6% (113/117). 18F-PSMA-1007 had a sensitivity of 91.2% and a positive predictive value (PPV) of 89.8% for the identification of intraprostatic lesions. The consistency test (Kappa = 0.305) indicated poor agreement between the pathologic T-stage and PSMA PET/CT T-stage. Based on ROC curve analysis, the appropriate SUVmax to diagnose PCa lesions was 8.3 (sensitivity of 71.3% and specificity 96.8%) with an area under the curve (AUC) of 0.93 (P < 0.001). This SUVmax cutoff discriminated PCa lesions from non-PCa lesions with a sensitivity of 74.4%, a specificity of 95.8% in the prospective validation group.

Conclusions
18F-PSMA-1007 PET/CT demonstrated excellent performance in detecting PCa. An optimal SUVmax threshold (8.3) could be utilized to identify lesions of PCa by 18F-PSMA-1007 PET/CT.

Trial registration
ClinicalTrials.gov Identifier: NCT04521894, Registered: August 17, 2020.
Direct hydrogen peroxide MRI fistulography versus indirect (intravenous) MRI fistulography in patients with perianal fistula
Authors: Abdelhalim Ahmed Hossam , Ali Mohamed Abd el Aziz , Farouk Mohamed Amr , Gamal Eldeen Noha Mohamed 
Published: November 2023

Abstract
Background
Perianal fistula is a rather common disease; its symptoms range from mild to severe, impairing anal continence; accurate preoperative evaluation avoids recurrence following surgical procedures.

Aim of work
Our study examined the diagnostic accuracy of magnetic resonance imaging with direct percutaneous instillation of hydrogen peroxide mixed with gadolinium (direct fistulography) in comparison to intravenous gadolinium contrast-enhanced study (indirect fistulography).

Methods
This prospective study was conducted on patients referred to Airforce hospital radiology department and were diagnosed with perianal fistula, Direct and indirect MR fistulography were performed using a 1.5T MRI scanner. The type of fistulae, internal openings, secondary branches, and abscesses were compared to surgical findings.

Results
Our study included 35 male patients. Both direct and indirect methods detected primary tracts with 97.1% sensitivity and accuracy rates of 91.9% and 89.2%, respectively. The direct method was superior in detecting secondary branches and internal openings with accuracy rates of 97.37% and 93.3%, respectively, compared to 86.8% and 86.6% for the indirect method, while the indirect method was superior in detecting abscess collections with 100% accuracy rate compared to 89.2% accuracy rate for the direct method. None of the patients reported fever or bleeding after the procedure.

Conclusions
Both direct and indirect fistulography showed comparable abilities in detecting primary fistulous tracts. However, the direct fistulography was superior in detecting internal openings and secondary tracts particularly in chronic cases, whereas indirect Fistulography was superior in detecting abscess collections. Incorporating both methods into our routine could thus improve the efficacy of surgical procedures.
Prostate-Specific Membrane Antigen–Targeting Alpha Emitter via Antibody Delivery for Metastatic Castration-Resistant Prostate Cancer: A Phase I Dose-Escalation Study of 225Ac-J591
Authors: Tagawa Scott T. , Thomas Charlene , Sartor A. Oliver , Sun Michael , Stangl-Kremser Judith , Bissassar Mahelia , Vallabhajosula Shankar , Castellanos Sandra Huicochea , Nauseef Jones T. , Sternberg Cora N. , Molina Ana , Ballman Karla , Nanus David M. , Osborne Joseph R. , Bander Neil H. 
Published: November 2023

PURPOSE Novel therapies are needed to extend survival in metastatic castration-resistant prostate cancer (mCRPC). Prostate-specific membrane antigen (PSMA), a cell surface antigen overexpressed in PC, provides a validated target. This dose-escalation study investigated the safety, efficacy, maximum tolerated dose (MTD), and recommended phase II dose (RP2D) for 225Ac-J591, anti-PSMA monoclonal antibody J591 radiolabeled with the alpha emitter actinium-225. METHODS Following investigational new drug-enabling preclinical studies, we enrolled patients with progressive mCRPC that was refractory to or who refused standard treatment options (including androgen receptor pathway inhibitor and had received or been deemed ineligible for taxane chemotherapy). No selection for PSMA was performed. Patients received a single dose of 225Ac-J591 at one of seven dose-escalation levels followed by expansion at the highest dose. Primary end point of dose-escalation cohort was determination of dose-limiting toxicity (DLT) and RP2D. RESULTS Radiochemistry and animal studies were favorable. Thirty-two patients received 225Ac-J591 in an accelerated dose-escalation design (22 in dose escalation, 10 in expansion). One patient (1 of 22; 4.5%) experienced DLT in cohort 6 (80 KBq/kg) but none in cohort 7; MTD was not reached, and RP2D was the highest dose level (93.3 KBq/kg). The majority of high-grade adverse events (AEs) were hematologic with an apparent relationship with administered radioactivity. Nonhematologic AEs were generally of low grade. Prostate-specific antigen (PSA) declines and circulating tumor cell (CTC) control were observed: 46.9% had at least 50% PSA decline at any time (34.4% confirmed PSA response), and protocol-defined CTC count response occurred in 13 of 22 (59.1%). CONCLUSION To our knowledge, this is the first-in-human phase I dose-escalation trial of a single dose of 225Ac-J591 in 32 patients with pretreated progressive mCRPC demonstrated safety and preliminary efficacy signals. Further investigation is underway.
The chromatin source-sink hypothesis: a shared mode of chromatin-mediated regulations
Authors: Murphy Patrick J. , Berger Frédéric 
Published: November 2023

ABSTRACT
We propose that several chromatin-mediated regulatory processes are dominated by source-sink relationships in which factors operate as ‘sources’ to produce or provide a resource and compete with each other to occupy separate ‘sinks’. In this model, large portions of genomic DNA operate as ‘sinks’, which are filled by ‘sources’, such as available histone variants, covalent modifications to histones, the readers of these modifications and non-coding RNAs. Competing occupation for the sinks by different sources leads to distinct states of genomic equilibrium in differentiated cells. During dynamic developmental events, such as sexual reproduction, we propose that dramatic and rapid reconfiguration of source-sink relationships modifies chromatin states. We envision that re-routing of sources could occur by altering the dimensions of the sink, by reconfiguration of existing sink occupation or by varying the size of the source, providing a central mechanism to explain a plethora of epigenetic phenomena, which contribute to phenotypic variegation, zygotic genome activation and nucleolar dominance.
Clinical Considerations in Returning Pediatric and Young Adults With Cancer to Physical Activity
Authors: Dykowski Sara , Simoneau Jillian , Smith Sean R. , Walling Emily , Lewno Adam 
Published: November 2023

Abstract
There is a gap in the literature on the best treatment of clinical sequelae within adolescent and young adult pediatric cancer populations. Children, adolescents, and young adults are at risk for a multitude of immediate and late effects of their disease and treatment that warrant a comprehensive, multidisciplinary team approach to optimize care. Sports medicine providers are well-equipped with their background to join the oncology rehabilitation team in diagnosing and managing cancer-related impairments to help these populations live a healthier and more active lifestyle. In this manuscript, four essential clinical components to consider when returning children, adolescents, and young adults with cancer history to physical activity are discussed: chemotherapy-induced peripheral neuropathy, cardiotoxicity, nutritional deficiencies, and deconditioning.
Exploring fraity and sarcopenia in older adults admitted to acute medical unit, looking at prevalence, trajectory, and outcomes: A protocol testing the feasibility and acceptability of the TYSON study
Authors: Kamwa Vicky , Jackson Thomas , Hassan-Smith Zaki , Sapey Elizabeth 
Published: November 2023

Background
Frailty and sarcopenia are common in older people and are associated with adverse outcomes including increased mortality and morbidity. It is unclear whether screening for frailty and sarcopenia would identify specific populations most at risk of poor outcomes during unplanned hospital admissions, which screening tools should be used and what the trajectory of both conditions are over the course of an admission. The TYSON study is an observational cohort study aiming to determine the prevalence, trajectory and outcomes associated with frailty and sarcopenia in different patient cohorts. This protocol tests the feasibility and acceptability of TYSON processes.

Objectives
To determine in acutely admitted medical patients who are older adults: Primary: The feasibility and acceptability of frailty and sarcopenia assessments; Secondary: (1) Differences in community and hospital frailty assessments, as assessed by the medical team, the patient and elderly care physicians, (2) The dynamic changes in frailty and sarcopenia during a hospital admission, and patient outcomes; Exploratory: Inflammatory and metabolic mediators associated with frailty and sarcopenia.

Methods
A single centre, prospective observational study including patients aged ≥ 65 years admitted to an acute medical unit. Frailty assessments include the Rockwood clinical frailty and e-frailty index. Sarcopenia assessments include the Bilateral Anterior Thigh Thickness (BATT) measurement. Each participant will be asked to complete 5 visits, at day 0, day 3, day 7, month 3 and month 6. Blood samples will be collected to explore inflammatory and metabolic markers associated with frailty and sarcopenia. The study and protocol have been ethically approved by the Health Research Authority (REC 20/WA/0263).

Discussion
The study will determine the feasibility and acceptability of frailty and sarcopenia assessments in an acute hospital setting, and inform on the prevalence, trajectory and associated outcomes of frailty and sarcopenia in this group of patients. An inflammatory and metabolic profile will be explored in frailty and sarcopenia.
The Benefit of Early and Frequent Antitumor Necrosis Factor-Alpha Trough Level Determination in Very Early-Onset Inflammatory Bowel Disease
Authors: Gillmore Taylor , Jimenez-Rivera Carolina , Mack David R. 
Published: November 2023

ABSTRACT
A patient with infantile-onset Crohn's disease had a partial response to corticosteroid therapy that worsened on its tapering, leading to treatment with antitumor necrosis factor-alpha monoclonal antibody therapy. Infliximab rapidly cleared before administration of the third accelerated induction dose with the development of antibodies. Adalimumab was initiated with a good clinical effect but also rapidly cleared, requiring dose intensification to improve drug levels and to maintain a good clinical response. The amount of medication could eventually be decreased. Accelerated induction and maintenance drug monitoring can prevent secondary loss of response in very young children with inflammatory bowel disease.
The Meaning of
ibtahala
in the Qurʾān: A Reassessment
Authors: Dost Suleyman 
Published: November 2023

Abstract
The word nabtahil, which appears only once in the Qur’an in Q 3:61, has become the basis of a fairly well-known practice in pre-modern and modern Islam called mubāhala, “mutual cursing” due to the verse’s alleged connection to a cursing duel between Muhammad and Christians from Najran. Some exegetes, however, took it to mean “to pray humbly/sincerely”. This article argues that among the two explanations offered by Muslim scholars and exegetes for ibtahala, “to pray” and “to curse”, the latter is quite probably incorrect and arose from a misinterpretation of the word’s solitary usage in the qur’anic verse whereas the former explanation fares better in view of the comparative Semitic evidence. Having evaluated the attestations of the word in Muslim sources and in other languages, I offer a third explanation, namely that the word ibtahala means “to debate”, based on a Classical Ethiopic cognate.
Design and performance investigation of a coherent optical system based
multi-band
OFDM with various indexes
Authors: Dawood Fatimah Imad , Hadi Wael Abdul Hassan 
Published: November 2023

Abstract
In this work, a comprehensive study of a multi-band optical orthogonal frequency division multiplexing (MB-OOFDM) system is investigated. Different OFDM indexes (128,256,512, and 1024) are utilized with the coherent detection CD technique. High-order modulation 16-quadrature amplitude modulation (16-QAM) is used to obtain high spectral efficiency. Transmission studies indicated that 128 subcarriers with 2-bands exhibit a higher optical signal-to-noise ratio (OSNR) of 23 dB with lower bit error rate (BER) of 1 × 10−4, while 1024 subcarriers with 8-bands shows a lower OSNR of 22 dB with a higher BER of 3 × 10−3. Even though the higher subcarrier type has the lowest BER, it provides a superior solution when combined with wavelength-division multiplexing (WDM) in the presence of forward error correction (FEC). The performance of the system with 40 Gbps along 800 km of uncompensated fiber has designed and simulated using Optisystem software.
An analysis of osteopathic medical students applying to surgical residencies following transition to a single graduate medical education accreditation system
Authors: Williamson Tyler K. , Martinez Victor H. , Ojo Desiree E. , Allen Christian B. , Fernandez Roberto , Larson Jason , Timoney Martin , Sees Julieanne P. 
Published: November 2023

Abstract

Context
Upon requests from osteopathic medical schools, the National Resident Matching Program (NRMP) Charting Outcomes were redesigned to include osteopathic medical school seniors beginning in 2018 and one joint graduate medical education (GME) accreditation system, the Accreditation Council for Graduate Medical Education (ACGME), formed in 2020.

Objectives
The goal of this study is to analyze the match outcomes and characteristics of osteopathic applicants applying to surgical specialties following the ACGME transition.

Methods
A retrospective analysis of osteopathic senior match outcomes in surgical specialties from the NRMP Main Residency Match data from 2020 to 2022 and the NRMP Charting Outcomes data from 2020 to 2022 was performed.

Results
For surgical specialties, results show matching increased as United States Medical Licensing Examination (USMLE) Step 2 CK (clinical knowledge) and Comprehensive Osteopathic Medical Licensing Examination (COMLEX) Level 2 CE (cognitive evaluation) scores increased along with the number of contiguous rankings (p<0.001). The greatest indication for matching looking at scores alone were those who scored greater than 230 on Step 2 CK compared to below (p<0.001) and above 650 on Level 2 CE (p<0.001). However, those who scored 240 (p=0.025) on Step 2 CK were just as likely to match as those who scored 250 (p=0.022) when compared to those who scored below those scores. Increasing research involvement had little to no significance with the likelihood of matching across most surgical subspecialties.

Conclusions
Our study demonstrates that there are unique thresholds for Step 2 CK scores, Level 2 CE scores, and the number of contiguous ranks for each surgical specialty that, when reached, are significantly associated with match success. Although certain board score delineations are linked with higher match success rates, the rates level off after this point for most surgical specialties and do not significantly increase further with higher scores. In addition, thresholds within contiguous ranks for increasing match likelihood exist and vary across surgical specialties. Overall, this study highlights that the quantitative metrics utilized to assess applicants lack the correlation reported historically, and the data presently available need to be more substantiated.
Rethinking chemical production with “green” hydrogen
Authors: Centi Gabriele , Perathoner Siglinda 
Published: November 2023

Abstract
This contribution critically addresses the “green” H2 production issue. After introducing the topic and the limits of the production of H2 from electrolysis, some examples of alternative methods are discussed, highlighting the possibility of reducing costs, carbon footprint and intensity of use of renewable energy compared to electrolysis.
Régi utakon Székelyföld Árpád-kori hegyi váraihoz
Authors: Botár István 
Published: November 2023

AbsztraktAz elrejtett mentsváraknak tekintett székelyföldi középkori várak elhelyezkedése nem függetleníthető a környezetükben húzódó terepobjektumoktól (őskori vár, népvándorlás kori sáncok, mélyutak, kápolnák). Ezek együttes vizsgálata és más adatok arra utalnak, hogy a várak „folyamatosan” használt utak mellé épültek, így a Magyar Királyság 13. századi határvédelmi rendszerének elemei voltak.