bluuebunny/crossref_metadata_2025_split huggingface dataset:
Effect of artificial sugar supply on ant-aphid interactions in protected horticulture
Authors: Foronda Jesús , Rodríguez Estefanía , Soler Juan J. , González Mónica , Téllez María del Mar , Robles-Vallet Carmen , Barranco Pablo , Ruano Francisca 
Published: February 2024

Abstract

Ant tending aphid colonies reduce the effectiveness of biological control on aphids which is detrimental to the crop plants. However, their mutualistic interaction is complex and, depending on the quantity and quality of the sugar that aphids produce, it may change to a predator-prey interaction. The objective of this study is to test this hypothesis by providing ants with a high-quality sugar supply with the predictions that ants with an extra-sugar source should more often predate on aphids and, therefore, the abundance of aphids on the experimental plants should be reduced. We carried out an experiment on pepper plants, inoculated with the aphid Aphis gossypii in greenhouses with naturally occurring Tapinoma ibericum colonies in three different periods. Our results showed a significant reduction in aphid colonies abundance and greater aphid predation by the ants in plants with an artificial sugar supply. However, the expected effects greatly varied among greenhouses and seasons. A negative effect on aphid abundance was mainly detected in autumn, while a positive effect on ants predating aphids were mainly detected in summer, when a lower ant activity on the plants occurred. Although our experimental results show that the artificial sugar supply changes ant behavior from tending aphids to preying on them, the large variation in the expected effects suggests that some other unconsidered factors influence their strength. Consequently, future advances should focus on detecting factors driving observed variations among study areas and year seasons, to continue research on using biological control for aphids in horticultural protected crops.
USP10 activates the FAK pathway by stabilizing RIOK3 in pancreatic ductal adenocarcinoma
Authors: Qin Henan , Sun Rui , Ning Zhen , Zhang Wenhe , Guo Xin , Fang Lei , Zou Kun , Li Shuang , Xu Mengyuan , Teng Yibin , Yin Peiyuan , Wang Aman , Liu Jiwei 
Published: February 2024

Abstract

Background The aberrant activation of FAK (Focal Adhesion Kinase) serves as a critical mechanism leading to heightened invasiveness and metastatic potential in pancreatic ductal adenocarcinoma (PDAC). FAK inhibitors have entered clinical trials, underscoring the significance of targeting FAK in treating PDAC. Further exploration of the regulation mechanism of FAK is crucial for advancing FAK inhibitors. Our previous study suggests that RIO Kinase 3 (RIOK3) facilitates the invasiveness and metastasis of PDAC cells by stabilizing FAK protein expression and upregulating its phosphorylation. Methods We used bioinformatics and IHC to measure Ubiquitin-specific protease 10 (USP10) mRNA and protein expression in PDAC based on TCGA and GTEx PDAC mRNA databases and two PDAC tissue chips from independent medical centers, and survival analysis was performed. Stable knockdown and overexpression experiments were performed on three different PDAC cells to elucidate the carcinogenic effect of USP10 through both in vivo and in vitro experiments. Co-IP and laser confocal experiments were carried out to confirm the interaction modes between USP10, FAK, and RIOK3. Deubiquitination experiments further validated the deubiquitination effect of USP10 on RIOK3. Finally, a prognostic model incorporating co-expression of USP10 and RIOK3 along with other factors influencing PDAC survival was established and validated using COX regression analysis. Results USP10 was associated with a poor prognosis in PDAC. In vitro experiments found that USP10 significantly promotes the proliferation, invasion, and migration of PDAC cells. Xenografted tumor and lung metastasis models in nude mice demonstrated that USP10 promoted the growth and metastasis of PDAC cells. Mechanically, USP10 interacts with FAK and RIOK3. RIOK3 acts as a bridge between USP10 and FAK. USP10 deubiquitinates and stabilizes RIOK3. In addition, RIOK3 overexpression can significantly compensate for the USP10 knockdown-mediated decline in FAK protein expression. Moreover, USP10 and RIOK3 co-expression is a significant factor associated with poor survival in the PDAC prognostic model. Conclusion USP10 deubiquitinates and stabilizes RIOK3 and activates the FAK signaling pathway, thereby inhibiting PDAC tumorigenesis, indicating that it may be a potential drug target for cancer treatment.
The Effectiveness and Safety of a Flexible Vacuum-Assisted Ureteral Access Sheath in Flexible Ureteroscopic Lithotripsy
Authors: Deng Guanyun , Wang Qing , Jiang Kehua , Lu Wenbing , Huang Kunyuan , Sun Fa 
Published: February 2024

Abstract
Objective: To investigate the efficacy and safety of a flexible vacuum-assisted ureteral access sheath (FV-UAS) in flexible ureteroscopic lithotripsy.
Methods: We collected data on procedures using a traditional ureteralaccess sheath (UAS) from May to November 2022 and those using a FV-UAS from December 2022 to June 2023 and conducted a retrospective analysis of the two groups of data. SIRS incidence, stone clearance rate and operation time were the main evaluation criteria. Age composition, sex, preoperative urinary leukocyte count, underlying disease, stone density and stone volume were used as secondary evaluation indices.
Results: There was no significant difference in age composition, sex, preoperative urinary leukocyte count, underlying diseases, stone density or stone volume between the two groups (P>0.05). The operation time of the UAS group (57.90±17.86) was higher than that of the FV-UAS group (48.40±15.89, P<0.05). The incidence of SIRS was lower in the FV-UAS (1.70% vs. 12.9%, P<0.05). The stone-free rate in both the UAS group and the FV-UAS group at 3 days after surgery was similar (20.97% vs. 20.33%, P>0.05), while the stone-free rate was 85.48% and 96.60% at 1 month after surgery (P<0.05), and the difference wasstatistically significant, especially the absolute stone-free rate (P<0.01)。
Conclusion: Compared with the UAS, the FV-UAS can reduce the incidence of SIRS postoperatively as well as shorten the operation time and improve the stone-free rate of flexible ureteroscopic lithotripsy.
GMMDA: Gaussian Mixture Modeling of Graph in Latent Space for Graph Data Augmentation
Authors: Li Yanjin , Xu Linchuan , Yamanish Kenji 
Published: February 2024

Abstract

Graph data augmentation (GDA), which manipulates graph structure and/or attributes, has been demonstrated as an effective method for improving the generalization of graph neural networks on semi-supervised node classification. As a data augmentation technique, label-preservation is critical, that is, node labels should not change after data manipulation. However, most existing methods overlook the label-preservation requirements. Determining the label-preserving nature of a GDA method is highly challenging, owing to the non-Euclidean nature of the graph structure. In this study, for the first time, we formulate a label-preserving problem (LPP) in the context of GDA. The LPP is formulated as an optimization problem in which, given a fixed augmentation budget, the objective is to find an augmented graph with minimal difference in data distribution compared to the original graph. To solve the LPP problem, we propose GMMDA, a generative data augmentation (DA) method based on Gaussian mixture modeling (GMM) of a graph in a latent space. We designed a novel learning objective that jointly learns a low-dimensional graph representation and estimates the GMM. The learning is followed by sampling from the GMM, and the samples are converted back to the graph as additional nodes. To uphold label preservation, we designed a minimum description length (MDL)-based method to select a set of samples that produces the minimum shift in the data distribution captured by the GMM. Through experiments, we demonstrate that GMMDA can improve the performance of graph convolutional network on Cora, Citeseer and Pubmed by as much as 7.75%, 8.75%, and 5.87%, respectively, significantly outperforming the state-of-the-art methods.
The ED 50 /ED 95 of esketamine in inhibiting body movement when patients undergoing hysteroscopy
Authors: Wang Dan , Li Shuangfeng , Wang Jun , Chen Shuai , Li Zhenzhen , Zhong Ying 
Published: February 2024

Abstract

Background
Patients would have a strong discomfort feeling and pain in hysteroscopic surgery because of expanding the cervical canal and tissue stretching. Nowadays, propofol has no analgesic effect, it is necessary to combine other analgesic drugs to inhibit intraoperative body movement and eliminate discomfortable feeling. This study was to explore the half effective dose (ED50) and 95% effective dose (ED95) of esketamine combined with propofol in inhibiting body movement when patients underwent hysteroscopy.
Methods
26 patients who needed hysteroscopy were recruited in Haikou Maternal and Child Health Hospital of China. All patients received intravenous esketamine and propofol. The plasma concentration of propofol was set to 3 µg/mL for target-controlled infusion. The dose of esketamine was determined by the Dixon up-and-down sequential method. The ED50/ED95 of esketamine were detected by binary regression (probit). The respiration, circulation and body movement of patients were observed. The operating time, the awakening time and the analgesic effect were recorded.
Results
The ED50/ED95 of esketamine combined with propofol plasma concetration 3 µg/mL inhibiting body movement in patients with hysteroscopy were 0.391 mg/kg and 0.476 mg/kg, respectively (95% confidence intervals were 0.34–0.431 mg/kg and 0.434–0.778 mg/kg). There are not respiratory and circulatory depression in all patients.
Conclusions
Esketamine at 0.476 mg/kg which combined with propofol plasma concetration 3 µg/mL showed a good analgesic effect in hysteroscopy.
What is the impact of CYP7B1 on the prognosis of endometrial cancer: a cohort study
Authors: Lu Xiao-Fang , Huang Tao , Chen Chang , Zhang Jing , Fu Xu-Yong , Cheng Bo , Zhou Ya-Yan , Lei Jia , Lu Da-Lin 
Published: February 2024

Abstract

Background: Endometrial cancer (EC) tissues express CYP7B1, but its association with prognosis needs to be investigated.
Methods: Immunohistochemistry and image analysis software were used to assess CYP7B1 protein expression in 307 paraffin-embedded endometrial tumor sections. Associations between CYP7B1 and clinical factors were tested with the Wilcoxon rank-sum test. Cox regression analysis was used to assess the association between CYP7B1 expression and the prognosis of patients with EC. Kaplan-Meier curves were employed to describe survival, and differences were assessed using the log-rank test.
Results: A total of 307 patients were ultimately enrolled with an average age of 52.6±8.0 years at diagnosis. During follow-up, 46 patients (15.0%) died, and 29 (9.4%) suffered recurrence. The expression of CYP7B1 protein was significantly greater in the cytoplasm than in the nucleus. Higher levels of CYP7B1 protein were observed in patients aged <55 years, in ER-positive patients and in PR-positive patients. Both univariate (HR=0.41, 95% CI: 0.18-0.90) and multivariate (HR=0.35, 95%CI:0.16-0.79) Cox regression analyses
demonstrated that high CYP7B1 protein expression predicted longer overall survival (OS). When considering only ER-positive patients, CYP7B1 protein expression was more strongly associated with OS (HR=0.20,95%CI:0.08-0.52). The 3-year OS and 5-year OS in the low-CYP7B1 subgroup were 81.6% and 76.8%, respectively; while in the high-CYP7B1 subgroup were 93.0% and 92.0%, respectively (P=0.021).
Conclusions: High CYP7B1 protein expression predicted longer OS, suggesting that it may serve as an important molecular marker for predicting EC prognosis.
Genomics and molecular breeding of soft rice- a locally evolved japonica line with unique ready-to-eat trait
Authors: Panja Suraj , Bhowmik Arpan Dey , Chattopadhyay Ansuman , Kar Rup Kumar , Dey Pradip Chandra , Dey Narottam 
Published: February 2024

Abstract

Low amylose containing parboiled soft rice is a natural wonder having ready-to-eat trait (RTE) with possible risk of high glycemic response (GR). In this present investigation typical Indian soft rice (var. Vogali Bora) was studied for biochemical basis, whole genomic and transcriptomic dissection followed by molecular breeding for improvement of yield and GR. Quantitative estimation showed that lower amylose (AC) to amylopectin ratio with low resistant starch (RS) in soft rice may be the possible biochemical basis of softness and high GR. Presence of a smaller number of SNPs in WAXY locus and significant down regulation of GBSSI loci supported the molecular basis of lower AC of soft rice like japonica sub varieties. But in comparison to normal rice higher number of SNPs in starch synthesis related genetic loci conferred that they are specially evolved for unique type of starch synthesis to acquire RTE trait which is further propped up by down regulation of a cascade of trait linked transcripts during grain filling. With respect to soft rice, inbreed lines showed improvement in yield related traits and better GR in mice model due to improved AC and RS content of F2:3 seeds. Though this group of rice is of japonica in origin, due to presence of unique type of sequence diversity and starch synthesis machinery, they possess RTE trait which is unique in rice and rice relatives. It made this study significant and in future, generation advancement of developed inbreed lines may produce healthy soft rice on a large scale.
Evaluation of Follow-up Colposcopy Procedures After Abnormal Cervical Screening Result Across a Statewide Study in Mississippi
Authors: Reaves Sydney , Hall Katherine C. , Stewart Mary W. , Wentzensen Nicolas , Ferrell Christina , Risley Carolann , Wells Jimmie , Rives Rhonda , Bobo Fajada , Daniels Jon , Farrington Kathy , Morgan Jody C. , Clarke Megan A. 
Published: February 2024

Abstract

Purpose:
Cervical screening is used to detect and treat precancers to prevent invasive cancers. However, successful prevention also requires adequate follow-up and treatment of individuals with abnormal screening results. The aim was to investigate demographics, clinical characteristics, and follow-up status for individuals needing colposcopy after an abnormal screening result.
Methods:
The STRIDES (Studying Risk to Improve DisparitiES) cohort comprises individuals undergoing cervical cancer screening and management at a Mississippi Health Department or University of Mississippi clinic. Follow-up status, demographics, and clinical data were assessed from electronic health records and, if necessary, patient navigation on individuals identified as needing a colposcopy after an abnormal screening.
Results:
Of the 1,458 individuals requiring colposcopy, 43.0% had the procedure within 4 months, 16.4% had a delayed procedure, and 39.5% had no documented follow-up, with significant predictors of follow-up identified as age and cytology diagnosis. Based on age, individuals 30 + were more likely to follow up with a colposcopy compared to individuals < 30 years (49% and 38.7%, respectively; p < .001). Individuals with cytology diagnoses of LSIL (52.9%), ASC-H (51.4%), and HSIL (62.3%) had higher percentages of adherence to follow-up colposcopy guidelines (p < .001).
Conclusion:
Despite high cervical cancer screening rates among Mississippians, a substantial portion did not have adequate next-step intervention. However, it is encouraging that highest risk individuals were more likely to have a colposcopy. Regardless, continuing to understand the underlying causes for incomplete follow-up is crucial for timely secondary targeted interventions to reduce cervical cancer burden, promote awareness, and improve health outcomes.
Fuzzy Metaphor Identification in Terminology: Artificial Neural Network for Reasoning in Cognitive Linguistics
Authors: Isaeva Ekaterina , Yasnitsky Leonid 
Published: February 2024

Abstract
Metaphor is a cognitive phenomenon used for mediating the dialogue between experts and non-experts. To date, research on automation of metaphor identification has focused chiefly on finding metaphor-related words and metaphorical patterns, as well as establishing conceptual mappings in texts. A neglected area in the field of computational linguistics is finding metaphorical terms. This work provides insights into using an artificial neural network for reasoning in cognitive linguistics. We created a multilayer neural network and trained it using the resilient backpropagation algorithm to determine the metaphoricity level in terms. Within the course of English for professional communication, the computer security students collected terms from modern computer security discourse. Each term in the sample was estimated for the percentage of metaphoricity by cognitive linguists, who adopted acknowledged methods for metaphor identification through the prism of cognitive approach to terminology on the one hand and automation of data retrieval on the other. The latter determined our choice of input parameters. This paper has demonstrated an 86% accuracy in artificial network performance. The data presented here also highlight the aptitude of the input parameters for potentially automated preprocessing. The postprocessing stage, including evaluating the input parameters' significance and error analysis, is done automatically. The strength of our work lies in the fuzziness of human-like artificial decision making. We have obtained satisfactory results demonstrating that artificial intelligence can contribute to evaluating the cognitive potency of terms. These findings add substantially to our previous research into linguistic mediation.
LGR5 Expression in Lymph Node Metastases of Colorectal Cancer: Clinicopathological Insights and Prognostic Implications
Authors: Sawaguchi Hiroshi , Uehara Takeshi , Iwaya Mai , Asaka Shiho , Nakajima Tomoyuki , Kamakura Masato , Nagaya Tadanobu , Yoshizawa Takahiro , Ota Hiroyoshi , Umemura Takeji 
Published: February 2024

Abstract
LGR5 is a promising cancer stem cell marker in colorectal cancer (CRC), and many studies have been conducted on primary tumors. However, LGR5 expression in lymph nodes has not been well studied. In this study, we identified LGR5 expression by RNAscope, a highly sensitive RNA in situ method, and analyzed its association with clinicopathological characteristics. Tissue microarrays were generated from primary tumors and lymph node metastases in paraffin-embedded blocks of 38 CRC surgical resection materials. LGR5 expression by RNAscope was evaluated by dividing the expression levels into negative and positive expression. In all but two cases of lymph node metastasis, LGR5-positive dots were detected in tumor cells, and there was a wide range of LGR5-positive cells. More LGR5-positive dots were identified in the gland-forming region. Twenty-three cases were classified into an high LGR5-expression group, and 15 cases were classified into an low LGR5-expression group. In the high LGR5-expression group, the histological grade was lower than in the low LGR5-expression group (P = 0.0159), while necrosis was significantly more prevalent (P = 0.0326), and the TNM stage was significantly lower (P = 0.0302). There was no association between LGR5 expression levels in lymph node metastases and LGR5 expression levels in primary tumor tissue. LGR5 expression in lymph node metastases may influence prognosis. Further analysis may lead to new therapeutic strategies.
Evaluating the Seasonal Diversity, Habitat Preference and Assemblages of Water birds in Agroecosystem at Central Kerala
Authors: NARAYANAN NEENA , C Latha 
Published: February 2024

Abstract
The study proposes to discuss about the seasonal water bird diversity, habitat preference, assemblages of water bird species and their conservation problems in different agroecosystems. Field visits was done once in a week during Jan. 2021-Jan. 2023. Freshwater and saline agroecosystems are the study areas used for the water bird survey. The water bird study was conducted by direct observation method, point count method and line transect method. Observations were made using binoculars (10 × 50 Nikon) and video camera (Nikon Coolpix p1000). Based on the pilot study in 2020, we decided to concentrate on 16 species of waterbirds coming in the 3 different orders i.e., Order Pelecaniformes, Ciconiiformes and Suliformes. Compared to the different study areas, a greater abundance of water birds was recorded in winter season, while a lesser abundance was observed in the monsoon season. The species richness was highest in saline agroecosystem and water bird congregation was more in freshwater agroecosystem. Saline agroecosystem was the most preferred habitat used for water bird species. Agroecosystems support the globally threatened water bird species such as spot billed pelican, darter, black headed ibis and painted stork. Many factors that are listed below threatens the agroecosystems and it causes the decreasing assemblages of water bird species. They are high water intake due to heavy rain, electric lines, high growth of water hyacinth, fishing nets, solid wastes and garbage deposited from toddy shops, pesticides used in fresh water rice farming, tourism, crackers, high level of fishing activities, habitat destruction, communication towers, predators and white flags were introduced by farmers.
Arabic translation and validation of the Clinician Administered Staden Schizophrenia Anxiety Rating Scale (S-SARS)
Authors: Fekih-Romdhane Feten , Mouzakzak Fadila Al , Abilmona Ghinwa , Dahdouh Oussama , Hallit Souheil 
Published: February 2024

Abstract
Background: Literature on anxiety in patients with schizophrenia of Arab origin is surprisingly scarce, particularly given that expressions of both psychotic disorders and anxiety disorders can be largely shaped by cultural factors. The present study proposes to complement the literature by examining the psychometric properties of an Arabic translation of the Staden Schizophrenia Anxiety Rating Scale (S-SARS) in a sample of chronic, remitted patients with schizophrenia from Lebanon. As the Arabic version of the Generalized Anxiety Disorder 7‑Item Scale (GAD‑7) has not been previously validated in an Arabic-speaking clinical population of patients with schizophrenia, this study had as a secondary objective to examine the psychometric properties of this scale before its use.
Method: his cross-sectional study has been conducted during August and October 2023. A total of 117 chronic inpatients diagnosed with schizophrenia who were remitted and clinically stable filled the survey, with a mean age of 57.86 ± 10.88 years and 63.3% males.
Results: Confirmatory factor analyses showed that all 10 items were condensed into a single factor and had high factor loading values between 0.53 and 0.81. The reliability of the Arabic version of the S-SARS was excellent as attested by a Cronbach’s alpha and a McDonald’s omega coefficients of 0.89 and .90, respectively. The score of Arabic S-SARS correlated positively with the GAD-7 scores (r = .55; p < .001), thus supporting good convergent validity. As for discriminant validity, findings showed positive correlations between S-SARS and depression scores as assessed using the Calgary Depressive Symptoms Scale. In addition, the Arabic S-SARS correlated negatively with general functioning, further supporting the good validity and clinical relevance of the scale. Finally, measurement invariance was established in the gender subsamples (males vs. females) at the configural, metric and scalar levels, with females showing more anxiety than males.
Conclusion: Findings suggest that the Arabic S-SARS holds good psychometric properties, and is suitable for use among Arabic-speaking patients with schizophrenia in clinical practice and research. The Arabic version of S-SARS will hopefully be widely applied to provide useful and timely clinical information for monitoring and adequately treating patients with schizophrenia, in order to improve the course and prognosis of the disease.