bluuebunny/crossref_metadata_2025_split huggingface dataset:
Causal role of 731 immune cells in pancreatic cancer: a Mendelian Randomization study
Authors: Feng Zhengyuan , Cao Ruiqi , Wu Jiaoxing , Mo Jiantao , Wang Qiqi , Wu Shuai , Ma Qingyong , Wang Zheng , Zhou Cancan , Wu Zheng 
Published: January 2025

Background:
Pancreatic cancer poses a significant worldwide health challenge. Immune cells are implicated in pancreatic cancer progression and therapy, yet the precise influence of distinct subsets of immune cells remains largely unexplored. The objective of this study is to pinpoint immunophenotypes linked to pancreatic cancer.

Methods:
Two-sample Mendelian randomization (MR) analysis was employed. Immune phenotypes were retrieved from GWAS, and pancreatic cancer data from the IEU project was split into training and validation sets. Causality was evaluated using the IVW, MR Egger, and weighted median methods. Evaluation included MR-Egger intercept test, funnel plot, leave-one-out analysis for horizontal pleiotropy, and Cochran's Q test for heterogeneity. Estimates from the two sets were combined using the fixed-effects meta-analysis methods.

Results:
6 immunophenotypes exhibiting inhibitory effects and 1 showing promoting role. Which is CD20 on IgD+ CD38- naive B cells (95% CI=0.765~0.948, P=0.003, OR = 0.852), CD24 on unsw mem B cells (95% CI=0.861~0.975, P=0.006, OR = 0.917), CD25 on B cells (95% CI=0.859~0.978, P=0.008, OR = 0.917), CD64 on monocyte (95% CI=0.802~0.921, P<0.001, OR = 0.859), CD25 on resting Treg cells (95% CI=0.784~0.957, P=0.005, OR = 0.866), CD39+ CD8br AC Treg cells (95% CI=0.816~0.971, P=0.008, OR = 0.890), HLA DR on B cell (95% CI=1.055~1.206, P<0.001, OR = 1.128) . None immunophenotype displayed potential reverse causality. The reliability of these results was confirmed by the fixed-effects meta-analysis methods.

Conclusion:
Our study has unveiled causal relationships between immunophenotypes and pancreatic cancer, which can offer guidance for future clinical and basic research endeavors.
Quality of Information in Carpal Tunnel Syndrome
Authors: Aguilar Javier Suárez , Florido Manuel Viñuela , Mayol Julio , Cristóbal Lara , Maldonado Andrés A. 
Published: January 2025

Introduction
Carpal tunnel syndrome (CTS) is the most common peripheral nerve entrapment disease, and it is a subject of great interest and concern to medical professionals and the general public. Our study aims to analyze and compare the quality and accuracy of the information related to CTS provided by social media platforms (SMPs) and the new large language models (LLM).

Methods
On YouTube, the first 20 videos in English and the first 20 videos in Spanish when searching for “carpal tunnel syndrome” and “síndrome túnel carpo” were selected. On Instagram, the first 20 videos with the hashtag #carpaltunnelsyndrome and #tunelcarpiano were chosen (in total 80 videos). Duration, number of likes, number of views, number of followers, upload date, and author category (medical specialist, patient, etc) were evaluated. Three specific questions about CTS were asked to 2 new LLMs (ChatGPT and Google Bard). The quality of information was analyzed and compared by two independent board-certified plastic surgeons using the Journal of American Medical Association (JAMA) and DISCERN scales.

Results
LLMs showed a significant higher quality of information when compared with SMPs based on the DISCERN scores (P < 0.05). Average DISCERN scores for answers given by ChatGPT and Google Bard were 52.83 and 57.83, respectively (good quality). In YouTube and Instagram, the average score for the 80 videos based on the JAMA scale was 1.92 (low reliability) and 25.18 (very low quality) on the DISCERN scale. Videos created by medical professionals in SMPs were associated with a higher JAMA and DISCERN scores (P < 0.05). 53.8% of the videos were made by a nonmedical author.

Conclusions
The quality of information from LLMs was good and significantly better than in SMP. A low participation of board-certified surgeons in SMP was found. Board-certified surgeons should be more involved in LLM and SMPs to increase leadership, improve education, and spread knowledge of peripheral nerve surgery.
Utility of Computed Tomography Angiography of the Head in the Management of the Blunt Trauma Patient with Intracranial Hemorrhage
Authors: Rady Emily Winifred , Shah Bhairav , Wierzbicki Katrina , Kenworthy Nathaniel , Lieber Michael , Radomksi Michal 
Published: January 2025

BACKGROUND
Computed tomography angiography of the head (CTAH) is not routinely obtained during the initial evaluation of patients with traumatic intracranial hemorrhage (ICH); however, it is useful for diagnosing vascular pathologies that may have led to the bleed. The aims of this study were to identify traumatic ICH patient characteristics on presentation that are associated with positive CTAH findings to elucidate which ones should prompt a CTAH and compare outcomes of patients with positive and negative CTAH findings.

METHODS
This is a retrospective cohort study of 522 patients who had blunt traumatic ICH and subsequently received CTAH between January 1, 2017, and January 1, 2022. Patients were then sorted into two cohorts: positive and negative CTAH findings. The CTAH findings were our primary outcomes and included a spectrum of traumatic vascular injuries as well as nontraumatic vascular pathologies. Secondary outcomes included mortality, intensive care unit admission, intensive care unit length of stay, and neurological intervention rates.

RESULTS
A total of 108 patients (20.7%) had positive CTAH findings. Patients with positive CTAH findings were more likely to be older, have lower heart rate, have more neurological deficits at admission, have fewer signs of external injury, and have increased need for cerebral angiogram and neuro-embolization. Patients with no pathologic CTAH findings were 3.9 times more likely to be alive at discharge. Initial heart rate and presence of neurological deficits on arrival were found to be independent predictors of positive CTAH findings.

CONCLUSION
Empiric CTAH is not necessary in all traumatic ICH patients. However, given the increased rates of neurologic procedures and mortality in patients with positive findings on CTAH, we recommend obtaining CTAH in blunt traumatic ICH patients who present with neurological deficits. The presence of external injuries alone should not influence the clinician's decision to obtain a CTAH.

LEVEL OF EVIDENCE
Prognostic and Epidemiological; Level III.
How does gameful experience foster customer engagement and brand advocacy? Consumer insights into branding in e-tail
Authors: Malik Garima , Pradhan Debasis 
Published: January 2025

Purpose
This study aims to examine the influence of gameful experience (GAMEX) on customer brand engagement in the context of e-tailing. Drawing on the self-determination and social learning theories, the authors have developed a comprehensive model incorporating cognitive, emotional and behavioral factors leading to brand advocacy and re-visit intention for the retail website.

Design/methodology/approach
The data for this study were obtained from 715 customers across various e-tailing websites. This research uses both quantitative method (partial least squares structural equation modeling − PLS-SEM) and qualitative method (fuzzy set qualitative comparative analysis − fsQCA) to investigate the relationship between GAMEX and customer brand engagement in the e-tailing context, with a focus on the long-term outcomes of brand advocacy and re-visit intention.

Findings
The PLS-SEM results indicate a significant impact of GAMEX on customer brand engagement. In addition, the findings reveal the moderating role of fear of missing out, internet self-efficacy and technoeustress in the association among GAMEX, customer brand engagement, brand advocacy and re-visit intention. The findings from fsQCA support the results obtained from PLS-SEM and reveal four configurations for brand advocacy and five configurations for re-visit intentions.

Originality/value
This research evaluates the impact of GAMEX on customer brand engagement using a mixed-method approach involving qualitative and quantitative procedures. This study offers valuable insights into the design of gamified marketing activities and current practices for fostering greater engagement.
Oil price uncertainty and capital structure dynamics
Authors: Alnori Faisal , Bugshan Abdullah 
Published: January 2025

Purpose
The literature is remarkably silent on questions concerning the nexus between firms’ capital structure adjustment speed and the uncertainty of oil prices. This study aims to examine how oil price fluctuations affect a firm’s capital structure and adjustment speed.

Design/methodology/approach
This research focuses on a set of corporations from the Gulf Cooperation Council spanning from 2011 to 2022. The methods applied are panel fixed effects and dynamic two-step system Generalized Method of Moments models.

Findings
The findings indicate that changes in oil prices significantly impact corporate capital structure. Specifically, high oil price volatility leads to a reduction in both market leverage and book leverage. In addition, increased volatility in oil prices results in higher costs for leverage adjustment speed, which subsequently influences how quickly companies move toward their optimal leverage ratio. It is observed that when there is an increase in oil price volatility, firms adjust their leverage more slowly. At the same time, they do so more rapidly during phases of lower oil price volatility.

Practical implications
The findings of this study hold significant implications for corporate managers, investors and lenders. The observed negative relationship between oil price uncertainty and leverage suggests that corporate managers may benefit from prioritizing equity financing over debt during periods of heightened oil price volatility. In addition, managers should integrate oil price uncertainty into their liquidity management strategies by maintaining sufficient cash reserves. This proactive approach can help mitigate the challenges posed by reduced access to external debt financing during volatile periods. Furthermore, understanding the influence of oil price fluctuations on firms’ cost of debt is crucial, as it directly impacts firms’ adjustment costs in achieving their optimal capital structures. Creditors, too, should consider the adverse effects of oil price volatility on corporate financing when designing credit policies, ensuring they remain responsive to the financial constraints faced by firms under such conditions.

Originality/value
At best, this study presents new evidence that sheds light on the nexus between oil price volatility and the speed at which firms adjust their leverage toward the trade-off theory’s optimal target.
Parameter influence analysis and optimization of wheel–rail creepage characteristics in high-speed railway curves
Authors: An Bolun , Liu Jiapeng , Yang Guang , Liu Feng shou , Shi Tong , Zhai Ming 
Published: January 2025

PurposeTo investigate the influence of vehicle operation speed, curve geometry parameters and rail profile parameters on wheel–rail creepage in high-speed railway curves and propose a multi-parameter coordinated optimization strategy to reduce wheel–rail contact fatigue damage.Design/methodology/approachTaking a small-radius curve of a high-speed railway as the research object, field measurements were conducted to obtain track parameters and wheel–rail profiles. A coupled vehicle-track dynamics model was established. Multiple numerical experiments were designed using the Latin Hypercube Sampling method to extract wheel-rail creepage indicators and construct a parameter-creepage response surface model.FindingsKey service parameters affecting wheel–rail creepage were identified, including the matching relationship between curve geometry and vehicle speed and rail profile parameters. The influence patterns of various parameters on wheel–rail creepage were revealed through response surface analysis, leading to the establishment of parameter optimization criteria.Originality/valueThis study presents the systematic investigation of wheel–rail creepage characteristics under multi-parameter coupling in high-speed railway curves. A response surface-based parameter-creepage relationship model was established, and a multi-parameter coordinated optimization strategy was proposed. The research findings provide theoretical guidance for controlling wheel–rail contact fatigue damage and optimizing wheel–rail profiles in high-speed railway curves.
Real‐world 52‐week effectiveness of deucravacitinib in psoriasis: A stratified analysis by age and body mass index
Authors: Hagino Teppei , Onda Marina , Saeki Hidehisa , Fujimoto Eita , Kanda Naoko 
Published: January 2025

AbstractDeucravacitinib, an oral tyrosine kinase 2 inhibitor, is effective for psoriasis. However, long‐term real‐world effectiveness stratified by age and body mass index (BMI) has not been precisely examined. This study aimed to evaluate 52‐week real‐world effectiveness of deucravacitinib in psoriasis patients, stratified by age (≥65 years vs <65 years) and BMI (≥25 vs <25). A prospective study was conducted from December 2022 to August 2024, involving 107 Japanese patients aged ≥15 years with moderate to severe psoriasis. Patients received 6 mg of deucravacitinib daily for 52 weeks. Therapeutic effectiveness was evaluated by the achievement rates of Psoriasis Area and Severity Index (PASI) 75, PASI 90, PASI 100, and other key clinical indices. Data were stratified by age and BMI. Mean PASI scores decreased until week 52 similarly in all patients’ groups stratified by age or BMI. The achievement rates of PASI 75, PASI 90, and PASI 100 at week 52 were 86.36%, 59.09%, and 13.64% in patients aged ≥65 years, while they were 86.36%, 65.22%, and 39.13% in patients aged <65 years, respectively, showing a slightly lower rate of PASI 100 in patients ≥65 years. The achievement rates of PASI 75, PASI 90, and PASI 100 at week 52 were 81.82%, 73.33%, and 18.18% in patients with BMI ≥25, while they were 88.24%, 82.86%, and 29.41% in patients with BMI < 25, respectively, and these rates at weeks 4, 16, 24, and 40 were slightly lower in patients with BMI ≥25. Deucravacitinib improved clinical indices of psoriasis patients during a 52‐week period in all patients' groups stratified by age or BMI. The present results indicate that deucravacitinib may be effective for elderly psoriasis patients as well as younger or middle‐aged patients, while effectiveness in patients with BMI ≥25 may be slightly lower compared with those with BMI < 25.
Biomarkers associated with progression of infantile hemangioma: Exploratory study
Authors: Miyazaki Ken , Kunimoto Kayo , Yasue Shiho , Endo Saori , Nozawa Akifumi , Ozeki Michio , Ishihara Takuma , Tanaka Minako , Kakimoto Nobuyuki , Suenaga Tomohiro , Tokuhara Daisuke , Ohnishi Hidenori , Inose Yuri , Jinnin Masatoshi 
Published: January 2025

AbstractTo identify patients with infantile hemangioma (IH) in need of early‐stage treatment in this multicenter, prospective, observational study, we investigated the potential of plasma cytokines as a clinically useful marker. Plasma samples were collected at three time points from 41 patients with infantile hemangioma: baseline (days 14–60 after delivery), visit 1 (days 61–150, the proliferative phase), and visit 2 (days 151–395, the involuting phase). With a twofold or more increase in tumor volume during the baseline–visit 1 period regarded as progression, progression was seen in 15 cases (36.6%). In the first step, cytokine arrays were performed using plasma samples in five progressive and five non‐progressive cases. Plasma levels of six cytokines at baseline were selected for a prediction marker of change in tumor volume during baseline–visit 1. Validation enzyme‐linked immunosorbent assay indicated that the baseline growth differentiation factor 1 (GDF1) concentration tended to correlate with the proliferation ratio of total lesions or target lesion during baseline–visit 1, although without statistical significance. However, the plasma GDF1 concentrations were significantly lower in patients with a fourfold or more increase in total volume (p = 0.013). Furthermore, changes in plasma interleukin (IL)‐7Rα levels showed a statistically significant inverse correlation between volume change of the target lesion during baseline–visit 1 (p = 0.0069). Our results suggest that plasma GDF1 measurement after birth is a useful marker for progression of IH. Additionally, the downregulation of IL‐7Rα that begins several months after birth may also contribute to tumor growth. (UMIN‐CTR: UMIN000038574).
Accommodation–repelling fields for mitigating human–goose conflicts
Authors: Valanne Valeria I. , Xu Yanjie 
Published: January 2025

AbstractResearch Highlight discussing: Seltmann, M., Ylitalo, A.K., Piironen, A., Store, R., Heikkinen, J., Heim, W., Piha, M., Seimola, T., Laaksonen, T., & Forsman, J. (2024). Arctic migrating barnacle geese utilize accommodation fields in a new agricultural staging area. Journal of Applied Ecology, https://doi.org/10.1111/1365‐2664.14838. Human–wildlife conflicts often involve wildlife damage affecting people's livelihoods. Many goose species have increased due to conservation efforts and agriculture practices. Their preference to forage intensively in agricultural areas has caused large‐scale damage to farmland, creating a conflict that needs effective mitigation solutions. Seltmann et al. investigated the effectiveness of accommodation‐and‐repelling‐field mitigation strategy by looking at habitat selection of satellite‐tracked barnacle geese (Branta leucopsis) at regional and local scales in an agricultural area of high goose impact. They found that geese at both scales preferred accommodation fields assigned in the study, suggesting the effectiveness of this management scheme in farmer–goose conflict mitigation. Their research highlighted the needs for refining and implementing locally tailored management strategies for wild birds in human‐modified landscapes by addressing their habitat selection, with regard to the balance between reducing human–wildlife conflicts and supporting biodiversity conservation in the context of global environmental change.
Entangled Illnesses: Embodied Experiences of Managing Multimorbidity
Authors: Oikkonen Venla , Helosvuori Elina , Ganesh Ahalya , Rokkonen Lilli Aini 
Published: January 2025

ABSTRACTMultimorbidity, meaning multiple long‐term conditions impacting a person's health, has become a rising societal and public health issue. The article contributes to the sociological study of chronic illness and multimorbidity by analysing how the blurriness of illnesses and entanglement of symptoms in multimorbidity is experienced and negotiated by people with coexisting chronic conditions. Drawing on qualitative interviews with people who live with endometriosis, fibromyalgia or hormonal migraine in Finland, we show how people with multiple chronic conditions distinguish between evolving symptoms based on past embodied experiences to make decisions about how to best manage their health. We argue that coexisting illnesses become entangled in ambiguous and open‐ended ways, which, if left unaddressed, complicates treatment. Our analysis of illness experiences is aligned with the growing body of literature that argues that the single‐disease model underlying healthcare systems fails to address the needs of patients living with multiple chronic conditions. Our emphasis on evolving entanglements between illnesses and the blurriness of conditions makes visible crucial discrepancies between lived illness and existing biomedical models and healthcare structures.
Information sharing across MLS platforms and housing prices: Evidence from a temporary suspension of an agreement
Authors: Cheng Ping , D'Lima Walter , Lin Zhenguo , Yang Liuming 
Published: January 2025

AbstractThis study examines a unique case of a suspension of a data‐sharing agreement between two multiple listing services (MLSs) in South Florida, and investigates the impact of such a (negative) shock on the trading outcomes of the MLS platforms. Using property listing data from the two MLSs, we find that sale prices were lower during the data suspension period for transactions involving properties that were in areas where the listing broker may rely on brokers from the other MLS to bring potential buyers. The negative price impact remains stable and consistent under various robustness checks. Furthermore, the results also reveal heterogeneous pricing and liquidity effects due to the data‐sharing suspension‐related shock.
Temperature Requirements Can Affect the Microbial Composition Causing Sour Rot in Grapes
Authors: Brischetto Chiara , Rossi Vittorio , Salotti Irene , Languasco Luca , Fedele Giorgia 
Published: January 2025

ABSTRACTSour rot (SR) is a late‐season non‐Botrytis rot affecting grapevines, resulting from a complex interplay of microorganisms, including non‐Saccharomyces yeasts and acetic acid bacteria. Nonmicrobial factors contributing to disease development encompass vectors (e.g., Drosophila spp.), the presence of wounds or microcracks on grape berry surfaces, and environmental conditions during berry ripening. The microbial complexes within SR‐affected grapes exhibit variability among different bioclimates and seasons, with certain microorganisms predominating under specific conditions. This study examined the influence of environmental conditions on the microbiome composition associated with SR‐affected grape bunches, utilising data from 41 locations across three distinct Italian bioclimates. We selected nine yeast and two bacterial species frequently isolated from sour‐rotted grapes for analysis. The growth responses of these microorganisms to temperature were assessed by categorising them into four ecophysiological clusters. Furthermore, we analysed the distribution of these microorganisms and their respective ecophysiological clusters across the three bioclimates. The results indicate that the microbiomes involved in SR can vary according to the bioclimatic conditions of the grape‐growing area. Further research is required to comprehend the ecological requirements of these microorganisms, define their ecological niches to understand their geographical distribution and epidemiology, and enhance SR management strategies.
Sulfate and Dissolved Organic Carbon Concentrations Drive Distinct Microbial Community Patterns in Prairie Wetland Ponds
Authors: Zahir Zohra , Khan Faraz , Hall Britt D. 
Published: January 2025

ABSTRACTPrairie wetland ponds on the Great Plains of North America offer a diverse array of geochemical scenarios that can be informative about their impact on microbial communities. These ecosystems offer invaluable ecological services while experiencing significant stressors, primarily through drainage and climate change. In this first study systematically combining environmental conditions with microbial community composition to identify various niches in prairie wetland ponds, sediments had higher microbial abundance but lower phylogenetic diversity in ponds with lower concentrations of dissolved organic carbon ([DOC]; 10–18 mg/L) and sulfate ([SO42−]; 37–58 mg/L) in water. As [DOC] and [SO42−] increased, there was an initial decline in abundance but not phylogenetic diversity. Maximum values of both abundance and phylogenetic diversity occurred between 56 and 115 mg/L [DOC] and 5,000–6,000 mg/L [SO42−] and decreased thereafter in ponds with 150–180 mg/L and 8,000–14,000 mg/L [DOC] and [SO42−], respectively. These findings confirm that environmental variables shape the microbial communities and that key microbial taxa involved in sulfur and carbon cycling dominated these ponds potentially impacting vital biogeochemical processes such as bioavailability of heavy metals, carbon sequestration, and methane emissions.