bluuebunny/crossref_metadata_2025_split huggingface dataset:
A Comparative Analysis of Topsis and Fuzzy- Topsis for Groundwater Potentiality Prediction in Basement Terrain Using Geophysical Data Sets
Authors: Mogaji Kehinde Anthony , SALAU Raheem Bodunde 
Published: November 2023

Abstract
This research combined remote sensing, geology and geophysical methods, fifty five (55) Vertical Electrical Sounding was carried out in the study area for proper groundwater potential investigation. In order to map groundwater potential of the area, eight thematic factors that influence groundwater occurrences and movement such as geophysical data (aquifer transmissivity, hydraulic conductivity, overburden thickness, recharge rate and aquifer resistivity), geologic data (lithology) and remote sensing data (slope and lineament) were ranked based on technique for order of preference by similarity to ideal solution (TOPSIS) and the developed Fuzzy technique for order of preference by similarity to ideal solution (FTOPSIS). The groundwater potential model map was evaluated using the developed FTOPSIS (Fuzzy Technique for Order of Preference by Similarity to Ideal Solution) and conventional TOPSIS. The groundwater potential of the area of study was qualitatively classified into five classes, namely; very high, high, moderate, low, and very low which account for 19%, 21%, 23.5%, 31.5%, and 5% of the total area respectively. The quantitative validated result of the developed GPM map (FTOPSIS) using the Receiver Operating Characteristics (ROC) technique, yielded the result of 0.84 which indicates 84% prediction accuracy while the prediction rate for the TOPSIS based model 0.75 representing 75% prediction accuracy respectively.
Optimization of Production Process Parameters for Polishing Machine Tools in Crankshaft Abrasive Belt based on BP Neural Network and NSGA-II
Authors: HE Xiao , LI Taifu , LI Qiaoyue , YANG Jie 
Published: November 2023

Abstract

In order to improve the polishing quality of the connecting rod journals of crankshafts and reduce polishing time for abrasive belt polishing machines, a method for optimizing the polishing process parameters for connecting rod journals is proposed, combining BP neural network and NSGA-II algorithm. Firstly, the factors affecting the polishing quality are screened, and in consideration of practical production requirements, a five-factor four-level orthogonal experiment is designed. Then, a BP neural network is used to establish a nonlinear mapping relationship between the polishing process parameters and the polishing quality of the connecting rod journals. The predicted results from the BP neural network are used as fitness values, and the NSGA-II algorithm is employed to obtain the Pareto frontier optimal solution set and the corresponding combination of polishing process parameters. Based on the optimization results, two sets of recommended process parameter schemes are provided. Compared to the initial process parameters of the polishing machine, one group can improve the polishing quality by 0.101 \(\mu\) m and reduce the polishing time by 5 seconds, while the other group can achieve an additional polishing time of 10 seconds in exchange for an improvement in polishing quality of 0.151$\mu$m. Finally, experimental validation has been conducted for the two sets of polishing process parameters, and the results align with the optimization expectations.
Dento-dental volumetric analysis in sagittal skeletal discrepancies: a retrospective observational study
Authors: Guarnieri Rosanna , Squillace Francesca , Rachele Podda , Monterossi Salvatore , Giorgio Roberto Di , Cassetta Michele , Galluccio Gabriella , Barbato Ersilia 
Published: November 2023

Abstract
Background: The aim of this study was to evaluate the correlation between skeletal Class and dental dimensions analyzed through linear, surface area and volumetric measurements.
Methods: The sample consisted of 90 patients with an average age of 18 years (44>x>12).
In order to investigate any correlation between skeletal Class and tooth size, the following tests were used: Hoeffding test, Cramer's V test, the analysis of variance test (ANOVA) followed by the Tukey’s post hoc hds test and the Logit model. The significance level was set at 0.050.
Results: The Hoeffding test showed a weak non-linear association between ANB and tooth values, expressed in millimetres, of element 1.4 (D = 0.0034, p < 0.05) and element 3.2 (D = 0.0042, p < 0.05). The same test also identified a non-linear association, also weak, between ANB and the lower (D = 0.0053, p < 0.05) and anterior (D = 0.0049, p < 0.05) total volumetric values. Cramér's V test indicated a weak association between skeletal Class (I, II, III) and total Bolton index (V = 0.167, p < 0.01). The results of the ANOVA test showed that the total inferior volume and the anterior inferior volume were respectively significantly greater (p = 0.012; p = 0.012) in the skeletal Class III (p = 0.012) than in the other two skeletal Classes. The total upper surface area was significantly greater in patients in skeletal Class III compared to those in Classes II and I (p = 0.029). The anterior superior surface area was significantly, greater in skeletal Class III than in Class II and I (p = 0.028). From the results of Logit analysis, it is possible to state that the third model is able to explain greater variability (21%) in terms of the distribution of results in the variables considered than the first (20%) and the second (14%).
Conclusions: Class III skeletal malocclusions are characterized by increased tooth surface and volumetric dimensions compared to Class I and Class II.
Proposal for analysis of minimum ecological flow regimes based on the achievement of technical and environmental objectives: Tagus river basin case study
Authors: Sanz Domingo Baeza , Iribas Beatriz Larranz , Calvo Patricia Chacón 
Published: November 2023

Abstract
An environmental flow regime can be used as a specific restoration measure to manage impacts on the river environment resulting from hydrological alterations or loss of structural or functional complexity of the ecosystem. With the entry into force of the WFD (Water Frame Directive), it is now also a measure to help achieve good environmental status. Once the values of its components are known, the regime should be tested to see if it can contribute to the achievement of the proposed objectives. However, the analysis of the validity of the proposal and its subsequent monitoring is not always carried out adequately. This paper presents a four-stage methodology for analysing the validity of a particular proposal prior to its implementation. The four stages include comparison with the natural regime, hydraulic simulation, validity in terms of habitability for fauna, its capacity to create habitat for fauna and a contrast with other proposals. This process is applied to the official environmental flow regime proposal for the third planning cycle in four sections of the middle course of the Tagus River (Spain). The results show that the official environmental flow regime is far from the natural regime, with very low minimum flows that do not contribute to the improvement of the fish habitat or to the conservation of the riverbanks. An alternative regime proposal is presented that gives better results than the official proposal. This proposed methodology can be useful as a control strategy prior to the implementation of an evironmental flow regime.
A meta-analysis and systematic review of randomized controlled trials in combination Gemcitabine with Erlotinib in the pancreatic cancer
Authors: Yan Longxiang , Lu Wenming , Huang Wenjin , Zoa Alexis Bindzi , Zheng Jiang , Qin Mingbai , Du Jing , Xiao Qiuxiang , Liu Zhiping , Tian Yuantong 
Published: November 2023

Abstract
Background and aim: Previous studies have demonstrated the efficacy and safety of combining Gemcitabine and Erlotinib (Gem-Erlo) for the treatment of pancreatic cancer (PaC). However, there is a limited number of clinical studies and multiple prospective randomized controlled clinical trials (RCTs) have yielded inconsistent conclusions. The question of whether Gem-Erlo has significant advantages over conventional chemotherapy in the treatment of PaC has been controversial. In order to provide valuable insights for PaC treatment, this study conducted a meta-analysis based on the current evidence from RCTs.
Method: We searched several databases including PubMed/Medline, Web of Science, Cochrane Library, and Embase, as well as relevant conference abstracts from the beginning of their inception to July 2023. We used the patient/population, intervention, comparison, outcomes and study design (PICOS) principle to screen the literature. After title, abstract and full text filtering, we extract the data from each study to assess the risk of bias by examining the quality of the literature. We used a meta-analysis with random effects model to synthesize and summarize the results regarding objective response rate (ORR), disease control rate (DCR), median progression-free survival (median PFS), median overall survival (median OS) and one-year survival rate.
Results: Seven RCTs were included, involving 2,152 PaC patients treated with either Gem-Erlo or Gemcitabine alone. The results showed that Gem-Erlosignificantly improved DCR (DCR = 1.74; 95% CI=[1.03, 2.92]; P = 0.04); but did not significantly improve median OS (SMD = −0.20; 95%CI=[−1.46, 1.06]; P = 0.75), median PFS (SMD = −0.97; 95%CI=[−4.01, 2.07]; P = 0.53), ORR (ORR = 1.29; 95%CI=[0.84, 1.97]), or one-year survival rate (ORR = 1.18; 95%CI=[0.88, 1.57]). The most common adverse events (AEs) were rash, diarrhea, fatigue, neutropenia and thrombocytopenia in both groups, but the Gem-Erlo group is more often than the Gemcitabine alone (ORR = 1.40, 95% CI= [1.19, 1.65]; P < 0.0001), and all AEs were within the acceptable range for patients.
Conclusion: Gem-Erlo can improve DCR when compared to Gemcitabine. There was no statistically significant improvement in median PFS, median OS, ORR and one-year survival rate. However, sensitivity analysis showed a statistical difference in the median OS. Our study indicated that Gem-Erlo had better efficacy than Gemcitabine alone in PaC therapy. The occurrence of AEs is under the acceptable range for patients.
A Theoretical Model of Microscallop in Shear Thinning and Shear Thickening Fluids
Authors: Murthy Yashaswini 
Published: November 2023

Abstract
The article develops a Lagrangian based model for a two-link mechanism termed a microscallop, moving in a low Reynolds number environment in a shear thinning/thickening fluid. The modelling proceeds through the conventional Lagrangian construction for a two-link mechanism and then goes on to model the external fluid forces using empirically based models for viscosity to complete the dynamic model. The derived model is then simulated for different initial conditions and key parameters of the shear thinning/thickening fluid - mainly time independent fluids such as shear thinning and shear thickening fluids, and the results are corroborated with existing experimental results on a similar mechanism under identical conditions. The resulting analytical model with complex nonlinearities is then simplified for further control-theoretic analysis. A few simulation-verified simplifications are introduced to study the accessibility of the system at various initial states. The final goal is to determine control algorithms for such a system to enable manipulation in its fluid environment.
Variation among cassava (Manihot esculenta Crantz) genotypes for storage root yield, yield components and response to cassava mosaic disease at advanced breeding stage
Authors: Mahamane Abdoul-Razak Oumarou , Olasanmi Bunmi , Oluwadamilola Udemba Ibukunoluwa , Mbanjo Edwige Gaby-Nkouaya 
Published: November 2023

Abstract
Cassava is a crucial starchy root crop cultivated worldwide in tropical and subtropical areas. Its preferred traits are continually been improved to enhance food and nutritional security. However, adoption of new varieties of cassava can be influenced by its yield performance which can be affected by cassava mosaic disease (CMD). This study was therefore conducted to evaluate the performance of selected cassava genotypes at advanced breeding stage across two years. Using a randomized complete block design with two replications, 16 genotypes; a yellow root variety (TMS07/0593) and a white root (TMS30572) as checks were evaluated for yield, yield related traits and response to CMD. There were highly significant (P < 0.001) variations among the cassava genotypes for yield-related traits but no genetic variation was reported for fresh root yield and dry root yield. The effect of season and genotypes x season interaction on all traits was not significant except season for harvest index. Genotype UIC-17-2428 and the two national check varieties (TMS07/0593 and TMS30572) did not exhibit complete resistance to CMD. At harvest, genotype UIC-17-2031 had the highest fresh root yield (39.0 t/ha), dry root yield (10.5 t/ha), and harvest index (0.63). Genotype UIC-17-58 had the highest dry matter content (37.2%) at harvesting followed by UIC-17-46 (36.4%) while genotype UIC-17-583 had the lowest value (22.8%). The genotypes evaluated have promising premium agronomic traits. Genotypes with outstanding dry root yield need to be evaluated across multiple environments to assess their stability.
Robots and inequality in Latin America: whose wages improve when automation is imported?
Authors: Olarte Susana Herrero , Galarraga Julio , Torrent Joan , Aguirre Kamila 
Published: November 2023

Abstract

We explore the consequences of robotization on labor income of all deciles in Latin America by estimating an unbalanced two-way fixed effects panel for 2004–2017. Results show that a raise in Latin American robotization favors middle skilled workers, specifically the labor income of deciles 5 and 6, which can be explained by the complementarity effect between machines and workers in the occupations associated to these deciles. Imports of robots in these countries are characterized by their reduced technology, which could increase the productivity of the majority of medium-skilled workers in deciles 5 and 6, that are non-agricultural workers, drivers of machinery and transport vehicles. Since the wages of low-skilled workers in Latin America are low compared to the cost of robots, these types of workers are not yet affected.
An easy-to-use Nomogram for Predicting Antituberculosis Drug- Induced Hepatotoxicity in Hospitalized Patients
Authors: Tang Daoyan , Wu Shouquan , Wang Minggui , He Jian-Qing 
Published: November 2023

Abstract
Background & aims:
Anti-tuberculosis (TB) drug-induced hepatotoxicity (ATDH) is one of the most deleterious side effects of anti-TB treatment. However, published data regarding prediction and prevalence of ATDH among TB patients were lacking.
Methods:
Hospitalized TB patients with retrospective data were extracted from the West China Hospital, Sichuan University. The predictors for ATDH were acquired by the least absolute shrinkage and selection operator (Lasso) and multivariate logistic regression methods were used to obtain the features related to ATDH.
Results:
279 ATDH cases and 725 non-ATDH controls were enrolled in the training group, and 150 patients were included in the validation group, including 33 ATDH.. C-index for discriminating between those with and without ATDH was 0.656 (95% CI: 0.619, 0.693) in training set, and the independent validation with 1000 bootstrap replications was 0.742 (95% CI: 0.652, 0.831). The decision curve analysis indicated that the threshold probability of ATDH was 15–67%.
Conclusion:
Our nomogram was a valuable tool to identify patients at high risk of ATDH in hospitalized TB patients and could improve the management of ATDH.
The effect of immune cell traits on efficacy and adverse drug reactions of platinum drugs： A Mendelian randomization analysis
Authors: Li Wanting , Yu Bing , Xiao Qi , Huang Hanxue , Cui Jiajia , Zheng Jifang , Qi Guangying , Yin Jiye , Liu Zhaoqian , Li Xi , McLeod Howard L. 
Published: November 2023

Abstract
Background
Platinum drugs are widely used in tumor chemotherapy, but the immune characteristics of different individuals have different effects on the sensitivity and side effects of platinum drugs. Therefore, we use Mendel randomized analysis to study whether peripheral blood immune cells have a causal relationship with the efficacy and adverse reactions of platinum drugs.
Methods
We used 731 kinds of peripheral blood immune cell traits of 3757 healthy individuals and 429 patients with non-small cell lung cancer (NSCLC) in Xiangya Hospital of Central South University to conduct a Mendel randomized analysis with two samples, in order to find out the causal relationship between some immune cell traits and the efficacy and adverse reactions of platinum drugs.
Results
First of all, we found 28 immune cell traits significantly related to the efficacy of platinum drugs, including 16 protective factors and 12 risk factors. Secondly, the protective factors of renal injury, BAFF-R is our focus, accounting for one third of all factors. Finally, we found that naïve-mature B cell is a protective factor for gastrointestinal upset and cutaneous toxicity.
Conclusions
This study emphasizes that B cell-related traits mainly affected gastrointestinal upset and cutaneous toxicity, while T cell-related traits mainly affected other outcome variables. These findings may promote our understanding of the relationship between the efficacy and adverse reactions of platinum drugs and the immune system, and promote the future development of biomarkers for predicting the efficacy and adverse reactions of platinum drugs.
Association between sensitivity to thyroid hormone indices and the risk of subclinical kidney damage in euthyroid adults: an NHANES Study (2007-2010) from United States
Authors: Wang Shen , Wang Yue , Sun Shuaifeng , Li Fadong , Pang Shuo , Wu Xiaofan 
Published: November 2023

Abstract
Objectives
subclinical kidney damage (SKD) and thyroid diseases are both common clinical diseases that lead to multi-system organ disfunction, and the relationship between the two diseases and their detailed mechanism have not been well described. This study aims to explore the correlation between thyroid function and SKD from a new perspective of sensitivity to thyroid hormone.
Methods
A total of 3451 United States euthyroid adults were included and divided according to quartiles of sensitivity to thyroid hormone indices from the National Health and Nutrition Examination Survey (NHANES) 2007–2010. Thyroid Feedback Quantile-based Index (TFQI), Thyrotroph Thyroxine Resistance Index (TT4RI, Thyroid-stimulating hormone (TSHI), and Free Triiodothyronine /Free thyroxine (FT3/FT4) represent the sensitivity of Hypothalamus-pituitary-Thyroid (HPT) axis and peripheral tissue to thyroid hormone, respectively. We apply logistic regression to analyze the associations between those indices with SKD.
Results
Subjects with SKD had elevated TSHI, TT4RI, and TFQI levels, and lower FT3/FT4 levels compared to those without SKD. Logistic regression analyses showed that higher TSHI, TT4RI, and TFQI levels were positively with SKD, but FT3/FT4 was negatively associated with the risk of SKD. In subgroup analyses stratified by gender and age, the associations between sensitivity to thyroid hormones and SKD were more obvious in men than in women and in age < = 65 years old than in age > 65 years old(P < 0.05). FT3/FT4 ratio performed better than TFQI, TSHI, and TT4RI on ROC analyses for SKD prediction. When thyroid parameters are categorized into quartiles, we found an interesting a “Simpson’s Paradox” phenomenon between sensitivity to thyroid hormone indices and SKD in the logistic regression analysis.
Conclusion
Impaired sensitivity to thyroid hormones was associated with SKD in United States euthyroid adults which illustrates the correlation between the thyroid system and SKD.
Inhibition of Importin 7-mediated IPO7/c-Myc/IPO7 positive feedback loop suppresses DNA damage repair and improves sorafenib sensitivity in hepatocellular carcinoma
Authors: Xue Song , Wu Yumeng , Zhang Xiubing , Xu Jian , Cai Hongyu 
Published: November 2023

Abstract
Background：Hepatocellular carcinoma (HCC) is a common malignancy worldwide with an increasing incidence. Sorafenib is currently the first-line treatment for HCC. However, drug resistance resulting from patients' insensitivity to the medication remains a major cause of high mortality. The specific mechanisms underlying sorafenib resistance in HCC have not yet been fully elucidated.
Methods：We have established the function of Importin7 (IPO7) in enhancing sorafenib sensitivity through DNA damage repair pathway through biological information. The expression of IPO7 in hepatocellular carcinoma and normal tissue and cell lines was detected by immunohistochemistry and western blot.Wound healing assay and Transwell assay were employed to examine the function of IPO7. The effect of γ-h2ax on the sensitivity of sorafenib was investigated by down-regulating IPO7. The mechanism between IPO7 and c-Myc was verified by bioinformatics prediction, western blotting, immunoprecipitation (IP), and immunofluorescence assay.
Results：Upregulation of IPO7 in liver cancer tissues correlates with an unfavorable prognosis for individuals with liver cancer. The suppression of IPO7 demonstrates a substantial inhibitory effect on the migratory and invasive capabilities of tumor cells. At the same time, inhibition of IPO7 can significantly up-regulate the expression of DNA damage repair factor γH2AX, and improve the sensitivity of sorafenib. Additionally, our findings demonstrate that IPO7 promotes the nuclear translocation of c-Myc, leading to the activation of the IPO7-driven DNA damage repair response to sorafenib. Conclusion: Our results provide new insights into the sensitivity of IPO7 to sorafenib and provide new potential targets for further investigation.