bluuebunny/crossref_metadata_2025_split huggingface dataset:
An earlier introduction of bow-and-arrow in southernmost Patagonia? firing experiments, survival curve models, and geometric morphometric methods to evaluate the use of Fell IV points as arrowheads
Authors: Charlin Judith , Cardillo Marcelo , Corada Juan Pablo Donadei , Arriaga Lucas Cheme , Moreno Eduardo , Shott Michael 
Published: December 2023

Abstract

In southernmost continental Patagonia (52º S) the introduction of the bow-and-arrow is traditionally associated with the appearance of the small Fell V or "Ona" points around 700 years ago. Earlier and larger Fell IV or "Patagonian" points were considered spear points. Our study focuses on a firing experiment with replicas of the Fell IV points hafted onto arrows that were repeatedly fired and resharpened until the end of their use-life. After each firing, surface impact (bone or meat), macrofractures, and the need for resharpening were recorded. Additionally, size measurements and plan-view photographs of each point at the beginning and end of the experiment, as well as after each resharpening, were documented to further analysis of size and shape variations. Survival-curve models were used to estimate the probability of point survival based on the number of shots and resharpenings endured. By employing landmark-based geometric morphometrics, blade-shape variations throughout replicas' use-life were compared to Fell IV and V archaeological points morphology. The experimental results exhibited the functional efficiency of Fell IV replicas used as arrowheads, with a variable but extended use-life averaging 21 shots and two resharpenings. Shape similarity is observed in the comparison of both experimental and archaeological point datasets. Therefore, an earlier adoption of bow-and-arrow technology in southernmost continental Patagonia is suggested according to experimental data and shape analysis. This technological innovation might be associated with the macroregional climate variations that affected in different ways the subsistence and settlement patterns of Patagonian human populations during the last ca. 2000 years BP.
Reducing variation in the quality of long covid care: Lessons from a national quality improvement collaborative and multi-site ethnography
Authors: Greenhalgh Trisha , Darbyshire Julie , Lee Cassie , Ladds Emma , Ceolta-Smith Jenny 
Published: December 2023

Abstract

Context
Long covid (post covid-19 condition) is a complex condition with diverse manifestations and uncertain prognosis. There is wide variation in how patients are investigated and managed. There have been calls for formal quality standards so as to reduce a so-called “postcode lottery” of care. We aimed to examine the nature of quality in long covid care and reduce unwarranted variation in care provided by long covid services.
Methods
In a mixed-method study (2021-2023), we ran a quality improvement collaborative across 10 UK sites. We also gathered data on the origins and current context of each clinic, interviewed staff and patients, and observed 12 clinics (52 consultations) and 34 multidisciplinary team (MDT) meetings (230 patient cases). Data collection and analysis were informed by relevant lenses from clinical care (e.g. evidence-based guidelines), improvement science (e.g. quality improvement cycles, reducing unwarranted variation) and philosophy of knowledge.
Results
The collaborative made progress towards standardizing assessment and management in some topics, but much variation remained. Clinics had different histories and path-dependencies, occupied a different place in their healthcare ecosystem and served a varied caseload including (in most clinics) a high proportion of patients with comorbidities. Dimensions of quality prioritized by patients related to the service (e.g. accessibility, ease of navigation), and human qualities of staff (e.g. attentiveness, compassion). A key route to quality long covid care was when local MDTs deliberated on unusual, complex or challenging cases for which evidence-based guidelines provided no easy answers. In such cases, collective learning occurred through idiographic reasoning, in which practitioners build lessons from the particular to the general. This contrasts with the nomothetic reasoning implicit in evidence-based guidelines, in which reasoning is assumed to go from the general (e.g. findings of clinical trials) to the particular (management of individual patients).
Conclusion
Not all variation in long covid services is unwarranted. Largely because long covid’s manifestations are so varied, universal ‘evidence-based’ standards are hard to define and implement. In this complex condition, quality improvement resources may be better spent supporting team-based learning locally than attempting to standardize care across widely differing services.
Trial registration
NCT05057260, ISRCTN15022307.
Unravelling stakeholder narratives on nature-based solutions for hydro-meteorological risk reduction—a multi-site case study in Southeast and Central Europe
Authors: Han Sungju , Luo Anran 
Published: December 2023

Abstract

This study delves into the landscape of stakeholder narratives concerning the implementation of nature-based solutions (NBS) for mitigating hydro-meteorological risks across five European river basin sites. Employing a hybrid approach of Q-methodology (N = 103) and narrative analysis, we identified four key narratives: optimist, sceptic, reformist, and pragmatist. These narratives reflect a spectrum of stakeholder values and attitudes towards NBS, from enthusiastic support to cautious scepticism. The optimists are hopeful about the multifaceted benefits of NBS, while sceptics raise concerns over its practicality and evidence of effectiveness. Reformists advocate for systemic improvements and transparent processes, whereas pragmatists emphasise tangible, immediate benefits and cost-effectiveness. Our findings underscore the importance of recognising and integrating this diversity of perspectives to develop NBS strategies that are resonant with stakeholders, thereby enhancing project acceptance and resilience against hydro-meteorological risks. Our findings provide an in-depth understanding of stakeholder views, contributing to a practical framework that aligns NBS projects with prevailing narratives. This comprehensive panorama of stakeholder perspectives offers valuable guidance for policymakers, practitioners, and researchers, aiding in the navigation of the complex landscape of NBS implementation. It bridges the gap between academic insights and real-world applications, underscoring the critical role of stakeholder engagement in effective risk management and sustainable environmental strategies.
Parametric study of coagulant recovery from water treatment sludge towards water circular economy
Authors: Shawal N. B. M. , Razali N. A. , Hairom N. H. H. , Yatim Norhafiza Ilyana I. , Rasit N. , Harun M. H. C. , Kasan N. , Hamzah Sofiah 
Published: December 2023

Abstract
This study aims to recover the used coagulants from two water treatment plants via acidification technique. The water treatment sludge (WTS) was acidified with sulfuric acid (H2SO­4) at variable normalities (0.5, 1, 1.5, 2.0 and 2.5 N). The surface morphology and functionalities of both recovered coagulants were analysed using scanning electron microscopy (SEM) and Fourier-transform infrared spectroscopy (FTIR). The performance of recovered coagulants was tested for turbidity removal in surface water treatment at different coagulant dosages and pH. It was found that the optimum normality of H2SO4 for recovered alum was 1.5 N, where 66% turbidity removal was recorded. The recovered PAC treated with 1.0 N H2SO4 indicated high turbidity removal percentage, which was 50.5%. The turbidity removal increased with increasing coagulant dosage. More than 80% turbidity removal was achieved with 40 mg/L dosage of recovered alum and recovered PAC. Maximum removal (85%) was observed with 50 mg/L dosage of recovered alum. For commercial coagulant, the turbidity removal was higher, with a difference of up to 6% in favor of recovered alum. The potential reuse of coagulants can be explored in order to reduce the operating costs and promotes the reduction of WTS disposal.
Cuidados do enfermeiro a recém-nascidos críticos no cateterismo epicutâneo auxiliado por ultrassonografia
Authors: Oliveira Márcia Farias de , Silvino Zenith Rosa , Vilar Andréa Maria Alves , ´Souza Cláudio José de 
Published: December 2023

Resumo
Introdução: Estudo de revisão, primeira fase de uma tese de doutorado, realizado com o objetivo de mapear evidências atuais que contemplem cuidados do enfermeiro a recém-nascidos críticos submetidos a cateterismo epicutâneo com ultrassonografia à beira do leito. Materiais e Métodos: Revisão de escopo, seguindo metodologia do Joanna Briggs Institute, com protocolo registrado na Open Science Framework. As buscas foram realizadas em cinco bases de dados e no Google Scholar, entre março e maio de 2022. A análise das citações dos estudos capturados foi um recurso utilizado para aumentar a amostra. Resultados: Os cuidados do enfermeiro que emergiram dos 22 estudos selecionados, publicados entre 2017 e 2022, em diversos países, foram apresentados por meio de quadro sinóptico, dividido em gestão do cuidado e cuidados diretos ao recém- nato nas fases de pré-inserção, inserção e manutenção e remoção do cateter. Discussão: A discussão narrativa realizada foi focada em recomendações atuais, derivadas da incorporação do ultrassom portátil ao processo estudado, tais como medidas suplementares para manutenção de barreira asséptica máxima, visualização de vasos mais aprofundados, escolha do cateter mais adequado ao vaso escolhido e confirmação da localização da ponta do cateter a partir de protocolos específicos, limitados. Considerações finais: O mapeamento realizado possibilitou a estratificação, baseada em evidências atuais, do cuidado do enfermeiro neonatal em cateterismo epicutâneo ecoassistido, e tem potencial tanto para contribuir no desenvolvimento de estudos futuros quanto para auxiliar nos cenários de prática, notadamente naqueles que visam incorporar o ultrassom em seus protocolos de enfermagem para estabelecimento de acessos venosos.
Descritores: Cateterismo Venoso Central; Ultrassonografia de Intervenção; Recém-Nascido; Unidades de Terapia Intensiva Neonatal; Cuidados de Enfermagem
influência da dieta da gestante na preferência alimentar e saúde bucal do bebê: revisão integrativa
Authors: Barbosa Carla Cristina Neves , Duarte Danilo Antonio 
Published: December 2023

Objetivo: Avaliar a influência da dieta de gestantes sobre a preferência alimentar do bebê e por consequência o reflexo para a saúde bucal do mesmo. Métodos: Trata-se de revisão integrativa da literatura (RIL), realizada em oito bases de dados, utilizando os descritores: Dieta na gravidez, Gustação, Sabor, Odontopediatria e Aleitamento Materno combinados com os operadores booleanos AND e OR. Incluíram exclusivamente artigos que respondiam à questão norteadora, nos idiomas inglês, português e espanhol. Excluíram artigos duplicados, teses, cartas e guidelines. Resultados: Inicialmente, identificaram-se 1340 artigos, restando 15 artigos após observação dos critérios de elegibilidade. Esses resultados expressam uma lacuna de conhecimento na temática, indicando notável premência de investigações que possam redundar em evidências acerca do estado atual do assunto. Considerações finais: A RIL permite inferir uma associação entre dieta da gestante, preferência alimentar e saúde bucal do bebê. Assim, é relevante ampliar e estimular programas de educação e segurança alimentar voltados para gestantes, visando reduzir vulnerabilidades do recém-nascido, abordando especificamente a saúde bucal.
Palavras-Chave: Alimentação na Gravidez; Paladar; Odontopediatria; Aleitamento Materno; Saúde Bucal.
Exploration of the Mechanism of Kaempferol in the Treatment of Cervical
Cancer-based on Metabolomics and Network Pharmacology
Authors: Cao Dong-Min , Liu Tao 
Published: December 2023

Background:
Cervical cancer is a prevalent malignancy among women globally.

Objective:
We aimed to uncover the mechanism of action of kaempferol in the treatment of cervical cancer using
an integrated approach that combines metabolomics with network pharmacology.

Methods:
Initially, we investigated the specific metabolites and potential pathways influenced by kaempferol
in the pathological progression of cervical cancer, employing UHPLC-Q-Orbitrap MS metabolomics. In addition,
network pharmacology analysis was performed to ascertain the pivotal targets of kaempferol in the context
of CC therapy.

Results:
Metabolomics analysis indicated that the therapeutic effect of kaempferol on cervical cancer is primarily
associated with 11 differential metabolites and 7 metabolite pathways. These pathways include arginine
and proline metabolism, the tricarboxylic acid cycle, phenylalanine, tyrosine, and tryptophan biosynthesis, fatty
acid biosynthesis, glycerophospholipid metabolism, pantothenate and CoA biosynthesis, and tyrosine
metabolism. Additionally, kaempferol was found to regulate 3 differential metabolites, namely palmitic acid,
citric acid, and L-tyrosine, by directly targeting 7 specific proteins, including AKR1B1, CS, EGFR,
PLA2G1B, PPARG, SLCO2B1, and SRC. Furthermore, molecular docking demonstrated strong binding affinities
between kaempferol and 7 crucial targets.

Conclusion:
This study elucidates the intricate mechanisms by which kaempferol acts against cervical cancer.
Furthermore, this research offers a novel approach to investigating the potential pharmacological mechanisms
of action exhibited by natural compounds.
Synergistic Effect, and Therapeutic Potential of Aqueous Prickly Pear
Extract. In vivo Neuroleptic, Catatonic, and Hypoglycemic Activity
Authors: Benattia Farah Kenza , Arrar Zoheir , Dergal Fayçal , Khabbal Youssef 
Published: December 2023

Background:
Prickly pear "Opuntia ficus indica (L.) Mill. "otherwise known as the Indian
fig tree, belongs to the family Cactaceae, and was known as a medicinal plant for its rich source
of bioactive substances.

Objective:
The present work aims to promote prickly pear seeds for traditional therapy by phenolic
profiling and pharmacological tests of aqueous extract.

Method:
An analytical quantification was performed by UV-Visible, and the identification of different
bioactive compounds was done by HPLC-DAD. For pharmacological screening, an in vivo
evaluation of the various tests, neuroleptic activity which consists of testing the recovery reflex;
catatonic activity which is a test to detect catalepsy that can be characterized in animals by the administration
of neuroleptic drugs; and for hypoglycemic activity a test was performed to assess glucose
tolerance.

Results:
The administration of aqueous extract of the prickly pear seeds at a dose (400 mg/kg) allows
a reduction in blood sugar with a maximum decrease of one and a half hours compared to the
control group.

Conclusion:
This work makes it possible to postulate that the extract of prickly pear seeds is associated
with a very interesting antihyperglycemic activity given its high content of phenolic compounds.
Neuroethological Analysis of the Effects of Venom of the Spider Vitalius
Platyomma (Theraphosidae, Theraphosinae) Microinjected into the Lateral
Ventricle of Wistar Rats
Authors: Ribeiro Alessandra Mussi , Estábile Eliane , dos Santos Cardoso Fabrizio , dos Santos Wagner Ferreira , Garcia-Cairasco Norberto 
Published: December 2023

Introduction:
Spiders are predators that use their venom to immobilize their prey. These
spider toxins are able to affect the central nervous system of mammals.

Methods:
We hypothesized that venom from the tarantula Vitalius platyomma may induce behavioral
changes in male Wistar rats. To test this hypothesis, the behavioral effects of venom were investigated
after intracerebroventricular microinjection using the neuroethological method (behavioral sequences)
associated with the ETHOMATIC program, evaluating frequency, duration, and strength of statistical
association between pairs (dyads) of behaviors.

Results:
The results obtained in this present study showed that the intracerebral administration of V.
platyomma crude venom provoked a difference in the time of freezing of animals. In addition, animals
showed after the freezing period changes in the exploratory and grooming clusters and additional complex sequences of behaviors such as wild running.

Conclusion:
This study clearly demonstrated the appearance of seizure-like behaviors, similar to audiogenic brainstem-dependent seizures such as those observed in genetically-selected audiogenic strains.
Social Media Use and Its Concurrent and Subsequent Relation to a Biological Marker of Inflammation: Short-Term Longitudinal Study
Authors: Lee David , Jiang Tao , Crocker Jennifer , Way Baldwin 
Published: December 2023

Background
Although many studies have examined the impact of social media use (SMU) on mental health, very few studies have examined the association of SMU with health-relevant biomarkers.

Objective
Addressing this gap, we conducted a short-term longitudinal study examining the link between SMU and C-reactive protein (CRP), a biological marker of systemic inflammation predictive of major depression, chronic diseases, and mortality.

Methods
We measured college students’ weekly amount of SMU for 5 consecutive weeks objectively via the Screen Time app and collected blood samples at baseline and 5 weeks later.

Results
In separate cross-sectional analyses conducted at phase 1 (baseline) and at phase 2 (5 weeks after baseline), objective SMU had a positive, concurrent association with CRP at both time points. Critically, in a longitudinal analysis, more SMU between phase 1 and phase 2 predicted increased CRP between these time points, suggesting that increased SMU led to heightened inflammation during that period.

Conclusions
Although more research is needed to understand why SMU led to higher inflammation, the association between objective SMU and a marker of a biological process critical to physical health presents an intriguing opportunity for future research on social media effects.
CONCEPT OF GOD, HUMANITY AND INSAN KAMIL: HALL AL-RUMUZ WA MAFATIH AL-KUNUZ MANUSCRIPT OF IBN ‘ARABI
Authors: Hajam  , Saumantri Theguh 
Published: December 2023

There are at least two items preserved in the manuscript of Ibn Arabi's Hall Rumuz wa Mafatihu al-Kunuz on the teaching of tasawuf, located in Cirebon Palace, West Java, Indonesia: Hall al-Rumuz (a collection of answers to every query based on the Sufi) and Mafatih al-Kurum (a brief summary of the secret of the teaching of tasawuf). A hermeneutic analysis of the library study highlights two important facets of Ibn Arabi's teaching: first, the knowledge that unlocks the treasure, and second, the possession of the key that enables one to reach the pinnacle of existence (al-Insan al-Kamil). To achieve perfection, one must possess a key as the method of access. Ibn Arabi stresses the significance of accurately comprehending the notions of divinity, humanity, and the road to perfection. This is to ensure that individuals do not forfeit their fitrah or their inherent identity as beings within a highly dynamic social environment.
Investigation of the Adsorption Properties of Electrically Conductive Pyrolyzed Polyacrylonitrile Modified with Chromium (III) Oxide to Obtain Highly Efficient Gas Sensors
Authors: Avilova M. M. , Zolotareva N. V. 
Published: December 2023

Introduction. Obtaining highly sensitive gas sensors is an urgent task, the solution to which will allow you to accurately and quickly assess changes in the air-gas composition of a given medium. Gas sensors based on metal-containing pyrolyzed polyacrylonitriles (Me-pPAN) are among the cheapest and most environmentally friendly gas-sensitive materials with a fast response. One of the types of sensor materials included in the Me-pPAN list is pyrolyzed polyacrylonitrile (pPAN) modified with a chromium (III) oxide molecule. The reasons for selective adsorption of pPAN and Me-pPAN to pollutant gases, which would allow controlling this process and obtaining sensory materials with increased sensitivity to gases, are not enough studied. Therefore, the aim of this work was to establish the main causes of selective adsorption of semiconductor electrically conductive films by modeling methods in the framework of molecular and quantum mechanics. Materials and Methods. The authors used modeling methods in the framework of molecular and quantum mechanics (MM2), the density functional theory (COSMO) method and the semi-empirical PM7 method in the MOPAC software package. Results. MM2 and PM7 methods were used to obtain models of adsorption complexes of "Cr-pPAN – gas-pollutant" systems. Thermodynamic parameters of the system were calculated for standard environmental conditions. The dependence of the adsorption of pollutant gases on the surface of Cr-pPAN on temperature has been established. Discussion and Conclusion. As a result of calculating the thermodynamic parameters of gas-pollutant–pPAN/Me-pPAN systems and obtaining positive values of Gibbs energies of these systems, it was confirmed that the adsorption of polluting gases on the surface of Cr-pPAN was not a spontaneous phenomenon and was effective at high temperatures. Considering that when chromium (III) oxide was introduced into the pPAN matrix, the charge on nitrogen atoms increased. It could be concluded that a chromium (III) oxide molecule had a positive effect on the semiconductor properties of pPAN. It was found that the adsorption of polluting gases (SO2 and NO2) was most likely on the surfaces of pPAN and Cr-pPAN. The results obtained in the work can be used to obtain gas-sensitive materials with specified metrological characteristics.
Plucking the forest sound
Authors: Chen Ying-Hsien 
Published: December 2023

This article examines Japanese enthusiasm for the Finnish kantele from the perspective of Borealism (Schram 2011). The question it addresses concerns the Northern characteristics that spring to mind among enthusiasts who use the kantele for recreational purposes. It also examines how these qualities are further used and developed in Japan. This cross-cultural music phenomenon reflects homogenous Japanese notions of the kantele, which influenced how its sound is used in a new environment. Borealism is reflected in the enthusiasts’ narrative and adoption of the instrument, which is perceived as an excellent tool with which to approach nature, fulfilling the fantasy and inspiring the imagination. The primary data comprises interviews and participant observation conducted in Japan between 2016 and 2018. Other supplementary materials include Internet data, liner notes, CD covers, promotional materials (posters, leaflets) and decorated instruments discursively gathered in the community.

Article cover photo: A five-string kantele painted green with Unikko as decoration, made in Sapporo, Hokkaido, 2009 (courtesy of Mitsuko Sato).
Об аппроксимации функций мощности перколяционных кластеров на равномерно взвешенных квадратных решетках с (1, 0)-окрестностью
Authors: Москалев Павел , Онищенко Леонид 
Published: December 2023

Исследуется проблема аппроксимации функций мощности перколяционных кластеров на квадратных решетках с (1, 0)-окрестностью. Для равномерно взвешенных квадратных решеток конечного размера исследована применимость модели, основанной на обобщении логистической функции. Статистические оценки коэффициентов модели получены с помощью нелинейного метода наименьших квадратов, при этом показано, что сдвиговой параметр модели значимо отличается от известных значений порога перколяции и предложены две интерпретации обнаруженного факта.