bluuebunny/crossref_metadata_2025_split huggingface dataset:
Decreased abdominal wall muscle mass defined by muscle ultrasound is associated with malnutrition according to Global Leadership Initiative on Malnutrition criteria in renal transplant recipients: A cross‐sectional study
Authors: Güner Merve , Girgin Sinem , Yıldırım Tolga , Okyar Baş Arzu , Ceylan Serdar , Öztürk Yelda , Koca Meltem , Balcı Cafer , Doğu Burcu Balam , Cankurtaran Mustafa , Halil Meltem Gülhan 
Published: February 2024

AbstractBackgroundChanged body composition with increased fat content and decreased muscle mass is seen in renal transplantation recipients (RTRs). Increased fat mass might mask underlying muscle mass loss; measuring low body mass index and weight reduction alone may not be sensitive enough to diagnose malnutrition in RTRs. We aimed to determine the prevalence of malnutrition in stable RTRs using the Global Leadership Initiative on Malnutrition (GLIM) criteria and to assess the use of muscle ultrasonography (US) to compare the performance of various muscle US measurements in the diagnosis of reduced muscle mass.MethodsNinety‐one patients who had renal transplantation >6 months ago were enrolled in the study. GLIM criteria were performed for all patients, but not those at risk of malnutrition. Bioelectrical impedance analysis and muscle US were performed to identify reduced muscle mass.ResultsThe prevalence of malnutrition according to GLIM criteria was 25.3% (n = 23). All muscle US measurements were lower in the malnourished group than the well‐nourished group; however, the malnourished group had substantially lower muscle thicknesses in abdominal muscles, specifically the external oblique (EO) and internal oblique (IO) muscles, than the well‐nourished group (P = 0.001 and P = 0.007, respectively). There was a significant association between malnutrition and EO (odds ratio [OR] = 0.338, 95% CI = 0.163–0.699; P = 0.003) and IO (OR = 0.620, 95% CI = 0.427–0.900; P = 0.012) regardless of age and sex.ConclusionOne in four RTRs experience malnutrition. Muscle US could be used effectively for the diagnosis of reduced muscle mass and malnutrition in RTRs according to GLIM criteria.
Ustekinumab is effective and safe in the long‐term treatment of erythrodermic psoriasis: Multicenter study in daily practice
Authors: Plana Clara , Concha‐Garzón Maria J. , Rocamora Vicen C. , Baniandrés Ofelia , Feltes Rosa , López‐Estebaranz Jose L. , Garcías‐Ladaria Joan , Carrascosa Jose‐Manuel , Vilarrasa Eva , Soria Caridad , Navajas Belen , Llamas‐Velasco Mar , Dauden Esteban 
Published: February 2024

AbstractBackgroundThe treatment of erythrodermic psoriasis (EP) is challenging. Biological therapies have shown promising results in the long‐term management of this clinical variant, but most of the current available evidence is based on single case reports and short case series.ObjectivesTo determine the effectiveness and safety of ustekinumab (UST) in the treatment of EP under daily practice conditions.MethodsWe conducted a retrospective, observational, nationwide, multicenter cohort study of patients diagnosed with EP treated with UST under daily practice conditions with up to 3 years of follow‐up. Outcomes, such as the psoriasis area and severity index (PASI) and safety, were assessed at months 1, 4, 7, 13, 19, 25, 31 and 37 during treatment. “As observed” and “intention‐to‐treat last observation carried forward (ITT‐LOCF)” analyses were performed.ResultsTwenty‐eight patients were enroled in the study. Baseline mean PASI was 43.1. A sharp decrease in mean PASI was observed during the first 7 months, reaching a plateau that was maintained until the end of the 37‐month follow‐up. At 7 months, 61% and 43% of the patients achieved PASI ≤ 2 and PASI 0, respectively. At 25 months, 48 (39%) (“as observed”/ITT‐LOCF) of the patients achieved complete clearance. At 31 months, PASI 75, PASI 90 and PASI 100 were achieved in 95, 80 and 45 (79%, 64% and 39%) (“as observed”/ITT‐LOCF) of the patients, respectively. Eleven patients required treatment intensification by reducing the interval between doses. Treatment minimisation was performed in four patients. During the follow‐up, nine patients (32%) received systemic combination therapy at some point. Eight patients discontinued treatment mainly due to lack of effectiveness. UST presented a good safety profile. With a follow‐up of 69.25 patient/years, only three patients exhibited serious nondrug‐related adverse events.ConclusionsUstekinumab can be a fast, effective and safe alternative for the long‐term treatment of erythrodermic psoriasis.
Validating the accuracy of the Hendrich II Fall Risk Model for hospitalized patients using the ROC curve analysis
Authors: Hu Chieh‐Ying , Sun Li‐Chen , Lin Ming‐Yen , Chen Mei‐Hsing , Hsu Hsin‐Tien 
Published: February 2024

AbstractThis retrospective study was conducted at a medical center in southern Taiwan to assess the accuracy of the Hendrich II Fall Risk Model (HIIFRM) in predicting falls. Sensitivity, specificity, accuracy, and optimal cutoff points were analyzed using receiver operating characteristic (ROC) curves. Data analysis was conducted using information from the electronic medical record and patient safety reporting systems, capturing 303 fall events and 47,146 non‐fall events. Results revealed that at the standard threshold of HIIFRM score ≥5, the median score in the fall group was significantly higher than in the non‐fall group. The top three units with HIIFRM scores exceeding 5 were the internal medicine (50.6%), surgical (26.5%), and oncology wards (14.1%), indicating a higher risk of falls in these areas. ROC analysis showed an HIIFRM sensitivity of 29.5% and specificity of 86.3%. The area under the curve (AUC) was 0.57, indicating limited discriminative ability in predicting falls. At a lower cutoff score (≥2), the AUC was 0.75 (95% confidence interval: 0.666–0.706; p < 0.0001), suggesting acceptable discriminative ability in predicting falls, with an additional identification of 101 fall events. This study emphasizes the importance of selecting an appropriate cutoff score when using the HIIFRM as a fall risk assessment tool. The findings have implications for fall prevention strategies and patient care in clinical settings, potentially leading to improved outcomes and patient safety.
Decisional Conflict in Patients with Advanced Laryngeal Carcinoma: A Multicenter Study
Authors: Heirman Anne N. , de Kort Daan P. , Petersen Japke F. , Al‐Mamgani Abrahim , Eerenstein Simone E.J. , de Kleijn Bertram J. , Hoebers Frank , Tijink Bernard M. , Stuiver Martijn M. , van der Molen Lisette , Dirven Richard , Halmos Gyorgy B. , van den Brekel Michiel W.M. 
Published: February 2024

ObjectivesDecision‐making for patients with a locally advanced laryngeal carcinoma (T3 and T4) is challenging due to the treatment choice between organ preservation and laryngectomy, both with different and high impact on function and quality of life (QoL). The complexity of these treatment decisions and their possible consequences might lead to decisional conflict (DC). This study aimed to explore the level of DC in locally advanced laryngeal carcinoma patients facing curative decision‐making, and to identify possible associated factors.MethodsIn this multicenter prospective cohort study, participants completed questionnaires on DC, level of shared decision‐making (SDM), and a knowledge test directly after counseling and 6 months after treatment. Descriptive statistics and Spearman correlation tests were used to analyze the data.ResultsDirectly after counseling, almost all participants (44/45; 98%) experienced Clinically Significant DC score (CSDC >25, scale 0–100). On average, patients scored 47% (SD 20%) correct on the knowledge test. Questions related to radiotherapy were answered best (69%, SD 29%), whilst only 35% (SD 29%) of the questions related to laryngectomy were answered correctly. Patients' perceived level of SDM (scale 0–100) was 70 (mean, SD 16.2), and for physicians this was 70 (SD 1.7).ConclusionMost patients with advanced larynx cancer experience high levels of DC. Low knowledge levels regarding treatment aspects indicate a need for better patient counseling.Level of Evidence4 Laryngoscope, 134:3604–3610, 2024
Characterizing Long‐Term Swallowing and Voice Outcomes Following Anterior Transcervical Approach
Authors: Toure Ahmed , Abend Audrey , Lipsky Rachel S. , Kutler David I. 
Published: February 2024

Objectives(1) Assess the frequency and severity of long‐term swallowing and voice complaints, follow‐up care, risk factors for the development of long‐term swallowing and voice complications in patients who underwent anterior transcervical approach (ACA). (2) Determine incidence of long‐term swallowing and voice complications requiring follow‐up otolaryngologic care and assess the frequency of otolaryngologic follow‐up for postoperative swallowing and voice complaints.MethodsRetrospective cohort study of patients between January 2017 and March 2020 who underwent ACA. Demographic information, data from preoperative evaluation, operative records, and data from postoperative visits were collected. Patients were contacted to complete the Eating Assessment Tool and the “Impairment” subset of the Voice Symptoms Scale.ResultsA total of 48 patients (10.6%) followed up with a head and neck surgeon for swallowing complaints and 31 patients (6.8%) for voice complaints. Otolaryngology follow‐up for swallowing complaints among patients with at least 3 and 12 months of follow‐up was 16.4% and 17.8%, respectively. Otolaryngology follow‐up for voice complaints among patients with at least 3 and 12 months of follow‐up was 11.7% and 11.9%, respectively. Swallowing function was abnormal in 40.7% at least 3 months after surgery and in 41.8% 12 months after. Voice function was abnormal in 55.7% of respondents at least 3 months after surgery and in 54.5% of respondents 12 months after.ConclusionsACA is associated with otolaryngologic complications that include dysphagia and dysphonia. This study demonstrates that long‐term swallowing and voice dysfunction appear to persist longer than what is noted by patient utilization of follow‐up otolaryngologic care.Level of Evidence4 Laryngoscope, 134:3201–3205, 2024
Combining approaches for environmental assessment of rehabilitated gold‐mining areas in the Eastern Amazon
Authors: Ramos Silvio Junio , de Oliveira Schweyka Stanley Holanda , Ribeiro Paula Godinho , Martins Gabriel Caixeta , da Silva Junior Ediu Carlos , Gastauer Markus , Caldeira Cecílio Frois , Pereira Wendel Valter da Silveira , Santos Diogo Corrêa , Sarmento Priscila Sanjuan de Medeiros , Nascimento Júnior Wilson da Rocha , Souza‐Filho Pedro Walfir Martins 
Published: February 2024

AbstractMonitoring key soil and vegetation attributes in mining areas under environmental rehabilitation is essential to ensure that the intervention techniques are effective. There are several approaches to monitoring mining areas and their integration is necessary to process large amounts of information. Thus, this study aimed to (i) assess soil multi‐contamination with potentially toxic elements (PTE) and human health risks; (ii) obtain a soil quality index with soil fertility data; (iii) calculate spectral index; (iv) show rehabilitation status based on vegetation attributes, and (v) compile these indices in a single measure. Four tailings' ponds (TPs), two waste piles (WPs), and an area of native forest from a gold mine in the Carajás National Forest were evaluated. Soil quality and vegetation cover are good in forest areas, with no evidence of PTE contamination. On the other hand, the TPs have poor fertility and vegetation cover, as well as higher levels of PTE. Human health risk indices obtained for all PTE were lower than 1, indicating a low risk to human health. The results of integrating the different indices suggest that the environmental conditions of the WPs are better than those of the TPs, which are still far from the environmental conditions of native areas. Soil attributes and vegetation development in TPs areas could be enhanced by the incorporation of organic materials and fertilizers and by planting species with phytoremediation potential. Finally, the integrative approach of the different indices proved to be useful in assessing the rehabilitation progress of the areas.
Detritivore physiology and growth benefit from algal presence during microbial leaf colonization
Authors: Feckler Alexander , Pietz Sebastian , Gonçalves Sara , Gerstle Verena , Risse‐Buhl Ute , Bundschuh Mirco 
Published: February 2024

AbstractIn headwater streams, riparian leaf litter is the primary food source for detritivores. While it is well known that aquatic fungi improve the nutritious quality of leaves, our understanding on whether and how benthic algae influence this process remains limited. Here, we hypothesized that the interplay between algae and fungi, termed “algal priming”, further enhances food quality. In a 40‐d microcosm experiment, we fed Gammarus fossarum of two size classes with Fagus sylvatica leaves of varying qualities: pure leaves (low quality), leaves colonized by fungi (intermediate quality), and leaves colonized by fungi in the presence of a diatom (high quality). Our results revealed that Gammarus' ingestion rates increased (55–164%) with food quality, spurring accelerated growth (4–14%), regardless of the size class. Furthermore, we observed a tendency for Gammarus' overall fatty acid (FA) quantity to rise with higher‐quality food (12–318%), with the FA profile exhibiting increased proportions of specific polyunsaturated FAs that are essential for detritivores. These observations can likely be attributed to leaf‐associated fungi, which are more readily assimilated than the leaves and are known as a source of FA. This enhancing effect by fungi was further amplified in the presence of diatoms, presumably through the positive effect of algal‐derived labile organic carbon, which supports fungal growth. Despite reduced autochthonous primary production in shaded headwater streams, the experimental findings from this study indicate a potential of enhanced secondary production and energy transfer to higher trophic levels within the aquatic ecosystem.
Parameter design and dynamic stability of controllable damping ferrofluid bearing
Authors: Liu Xuhui , Xu Wenqiang , Hu Huina , Wu Yan , Yan Pianpian , Xu Bin 
Published: February 2024

AbstractThe purpose of this paper is to carry out parameter design and dynamic stability verification experiment of controllable damping ferrofluid bearing. A new type of ferrofluid bearings is designed, and its internal magnetic fields are simulated by the finite element analysis software ANSYS. In this paper, the coefficient of magnetic leakage is taken as the optimization object, and the optimal parameters of ferrofluid bearings are updated. At the same time, the working principle of the ferrofluid bearings test platform is introduced, which includes a servomotor with a controller, an eddy displace sensor, an amplifier and a power supply. Finally, the dynamic stability of ferrofluid bearing is verified by experiments. The experimental results show that when the applied current is less than or equal to 0.08 A, the amplitude of the rotor supported by the ferrofluid bearing decreases with the applied current increment. Besides, the dynamic stability of the rotor is also related to the rotational speed. When the applied current is 0.08 A, the amplitude of the rotor supported by the ferrofluid bearing firstly increases and then decreases with the rotational speed increment. It is proved that the ferrofluid bearings have a strong function of the dynamic stability, which can suppress the vibration of the rotor, and have high accuracy of both position and rotation.
How do username and avatar affect people's engagement with native advertising on social media: From the self‐disclosure perspective
Authors: Yang Yanwu , Zhang Jun , Gao Ting (Lisa) 
Published: February 2024

AbstractThe effect of self‐profiling on people's responses toward commercial information (e.g., advertisements) delivered on social media remains unexplored. This study proposed a conceptual model examining the path from the authenticity of username and avatar and its antecedents to native advertising engagement from the perspective of self‐disclosure. Four subsequent studies were conducted to test our research model. The results indicated that the authenticity of username and avatar is a crucial determinant of engagement with advertising information. Moreover, social media involvement moderates the relationship between the authenticity of username and avatar and advertising engagement. Social media engagement partially mediates the relationship between the authenticity of username and avatar and advertising engagement. Regarding the antecedents of the authenticity of username and avatar, self‐presentation, relationship building, privacy concerns, privacy risks and trust belief are significant, while relationship maintenance is insignificant. This study contributes to our understanding of self‐profiling authenticity and its effect on people's engagement by employing the theory of self‐disclosure in the context of social media and provides critical managerial insights for social media platforms and advertisers.
Ionic Thermoelectric Generators in Vertical and Planar Topologies Based on Fluorinated Polymer Hybrid Materials with Ionic Liquids
Authors: Pereira Nelson , Afonso Luis , Salado Manuel , Tubio Carmen R. , Correia Daniela M. , Costa Carlos M. , Lanceros‐Mendez Senentxu 
Published: February 2024

AbstractIonic thermoelectrics (TEs), in which voltage generation is based on ion migration, are suitable for applications based on their low cost, high flexibility, high ionic conductivity, and wide range of Seebeck coefficients. This work reports on the development of ionic TE materials based on the poly(vinylidene fluoride‐trifluoroethylene), Poly(VDF‐co‐TrFE), as host polymer blended with different contents of the ionic liquid, IL, 1‐ethyl‐3‐methylimidazolium bis(trifluoromethylsulfonyl)imide, [EMIM][TFSI]. The morphology, physico‐chemical, thermal, mechanical, and electrical properties of the samples are evaluated together with the TE response. It is demonstrated that the IL acts as a nucleating agent for polymer crystallization. The mechanical properties and ionic conductivity values are dependent on the IL content. A high room temperature ionic conductivity of 0.008 S cm−1 is obtained for the sample with 60 wt% of [EMIM][TFSI] IL. The TE properties depend on both IL content and device topology‐vertical or planar‐the largest generated voltage range being obtained for the planar topology and the sample with 10 wt% of IL content, characterized by a Seebeck coefficient of 1.2 mV K−1. Based on the obtained maximum power density of 4.9 µW m−2, these materials are suitable for a new generation of TE devices.
Administrative penalties and corporate CSR disclosure strategies
Authors: Duan Linlin , Zhang Jintao , Meng Li 
Published: February 2024

AbstractCorporate social responsibility (CSR) disclosure is an important way for firms to achieve social goals. As stakeholders pay more attention to CSR performance, the CSR report strategy has attracted academic attention. Prior studies have stressed the important role of positive CSR disclosure strategies in a firm's reputation and market value, but our study shows different findings. Using a sample of China's A‐share listed firms from 2008 to 2019, we find a significant negative correlation between administrative penalties and the use of pictures and tables in CSR reports, which is more significant for firms being penalized rather than individuals in firms. Investor attention and agency costs provide a mechanism explanation. Heterogeneity analysis shows that in regions with a low level of legal institutions, the effects of administrative penalties on the use of pictures and tables in CSR reports are more significant. Nevertheless, the seemingly negative disclosure strategy ultimately contributes to corporate value.
Novel Targets and Potential Mechanisms of Mizuhopecten yessoensis‐Derived Tripeptide NCW as Antihypertensive Peptides
Authors: Wu Sijia , Zhao Wenzhu , Yu Zhipeng 
Published: February 2024

ScopeMizuhopecten yessoensis‐derived tripeptide Asn‐Cys‐Trp (NCW) exhibits a potent antihypertensive effect in vivo. However, a lack of knowledge of the antihypertensive mechanism of tripeptide NCW limits its application for functional foods industrialization. The purpose of this study is to elucidate the corresponding targets and mechanisms of tripeptide NCW in hypertension regulation.Methods and resultsAdministration of tripeptide NCW for 3 weeks, the blood pressure of spontaneously hypertensive rats (SHRs) is significantly decreased. After sacrifice, the serum sample is analyzed using tandem mass tag (TMT)‐based liquid chromatography with tandem mass spectrometry to identify differentially expressed proteins. The proteomic analysis indicates that tripeptide NCW administration alters serum protein profiles in SHR rats, significantly upregulating 106 proteins and downregulating 30 proteins. These proteins enhance the glycolysis, glucose, and TCA cycle, improve amino metabolism, trigger the cAMP/PKA, cGMP/PKG, PI3K/AKT, and AMPK signal pathways, and inhibit Ras‐regulated JNK activation, TGF‐β/MAPK, and TGF‐β/ RhoA/ROCK pathways.ConclusionTripeptide NCW supplementation is demonstrated to regulate signal pathways involved in the control of blood pressure and regulate the energy and amino acids metabolic processes in serum, providing important insights into the protective effects of tripeptide NCW on hypertension.
Echinacoside Exerts Antihepatic Fibrosis Effects in High‐Fat Mice Model by Modulating the ACVR2A‐Smad Pathway
Authors: Liang Jie , Chen Ting , Xu Honglei , Wang Tingfang , Gong Qi , Li Tingting , Liu Xiaoyan , Wang Jing , Wang Yun , Xiong Liyan 
Published: February 2024

ScopeNonalcoholic steatohepatitis (NASH) is an increasingly common chronic liver disease in which hepatic fibrosis is the major pathological change. The transforming growth factor β (TGF‐β)/mall mothers against decapentaplegic (Smad) signaling is the main effector of fibrosis. Although the antifibrotic effect of echinacoside (Ech) on the liver has been indicated previously, the cellular and molecular mechanisms remain unclear. This study aims to investigate both in vivo and in vitro antifibrotic properties of Ech.Methods and resultsCell viability and scratch/wound assays show that Ech significantly inhibits the proliferation, migration, and activation of human hepatic stellate LX‐2 cells. In mice with high‐fat diet‐induced hepatic fibrosis, Ech treatment attenuates the progression of liver injury, inflammation, and fibrosis. Furthermore, transcriptome analysis and subsequent functional validation demonstrate that Ech achieves antifibrotic effects by the activin receptor type‐2A (ACVR2A)‐mediated TGF‐β1/Smad signaling pathway; ultimately, ACVR2A is demonstrated to be an important target for hepatic fibrosis by inhibiting and inducing the expression of ACVR2A in LX‐2 cells.ConclusionEch exerts potent antifibrotic effects by inhibiting the ACVR2A‐mediated TGF‐β1/Smad signaling axis and may serve as an alternative treatment for hepatic fibrosis.