bluuebunny/crossref_metadata_2025_split huggingface dataset:
The role of purchasing and supply management in diffusing sustainability in supply networks: A systematic literature review
Authors: Miandar Toloue , E. Johnsen Thomas , Caniato Federico 
Published: October 2023

AbstractOne of the most difficult supply network challenges facing companies today is how to diffuse sustainability not only among their direct (first‐tier) suppliers but also throughout their supply networks. Although a growing body of research has been dedicated to addressing this challenge, the role of purchasing and supply management (PSM) in sustainable supply network development remains underexplored. In this paper, we present a systematic review of the literature on the role of PSM in the diffusion of sustainability in supply networks. We analysed 133 peer‐reviewed papers published in 21 journals in the field of PSM. We scrutinized the theories, methods and levels of analysis used in sustainable PSM research, classified the practices for diffusing sustainability in supply networks and identified the role of PSM in the diffusion of sustainability. Accordingly, we put forward a set of propositions that link diffusion practices—and the role of PSM in these practices—with embedded and peripheral sustainability and suggest future research directions.
The radiological unknown primary of the head and neck: Recommendations for imaging strategies based on a systematic review
Authors: Madani Gitta , Arain Zoya , Awad Zaid 
Published: October 2023

AbstractObjectivesTo develop recommendations for the radiological investigation of clinically occult primary cancer in the head and neck.Design and SettingIn accordance with PRISMA guidelines, a search was performed on Medline, Embase and Cochrane library databases to investigate the efficacy of ultrasound guided Fine Needle Aspiration (US FNAC), contrast enhanced CT (CECT), magnetic resonance imaging (MRI) and 18F‐fluorodeoxyglucose PET‐CT (18F‐FDG PET‐CT) in the investigation of head and neck squamous cell carcinoma from an unknown primary (HNSCCUP) presenting with a metastatic cervical lymph node (s). The Quality Assessment of Diagnostic Accuracy Studies Version 2 tool and SIGN 50 guidelines were used to assess the risk of bias and quality of the included studies.ParticipantsAdult patients presenting with metastatic cervical lymph nodes from a HNSCCUP.Main Outcome measuresUtility of different imaging modalities (PET‐CT, MRI, CE CT and US FNAC in the management of HNSCCUP).ResultsTwenty‐eight studies met inclusion criteria; these were meta‐analyses, systematic reviews, prospective and retrospective studies.ConclusionsThe optimal imaging strategy involves utilisation of various imaging modalities. US FNAC can provide the initial diagnosis and HPV status of the occult primary tumour. CECT and MRI detect up to 44% of occult tumours and guide management. FDG PET‐CT is the most sensitive imaging modality for the detection of CUP and should be performed prior to panendoscopy.
Improving implementation of best practices in obesity management: Physician experiences in obesity care
Authors: Lee‐Baggley Dayna , Fils‐Aimé Nadège , Audet Isabelle , Barakat Maxime 
Published: October 2023

SummaryIn this study, we sought to analyse experiences in weight management among physicians working in the area of obesity and contrast these experiences with best practices. By understanding experiences of physicians working in obesity management, we can better support implementation of best practices in their day‐to‐day practice. An online survey of Canadian primary care physicians, internists and endocrinologists recruited from a nationwide market research database was conducted. The survey captured demographic characteristics and perceptions about weight loss and its management. One hundred and ninety‐two physicians (140 primary care, 22 internists and 30 endocrinologists) were recruited and completed the survey. Challenges identified by the physicians in helping patients lose weight included patients' poor compliance and lack of time and resources to address the issue. Most physicians reported considering obesity to be a chronic disease, but most did not incorporate a multi‐dimensional, chronic disease model of obesity treatment (i.e., combination of lifestyle interventions with psychological, medical and/or surgical interventions). Endocrinologists reported management practices consistent with a chronic disease model more frequently than primary care physicians. These data highlight the need for improvement in obesity management, particularly in primary care. Despite proliferation of guidelines on best practices, implementation of these practices into daily practice remains low.
Fotografie in der Dermatologie – ein Scoping Review: Praktiken, Skin of Color, Patientenpräferenzen und medizinisch‐rechtliche Überlegungen
Authors: Kashetsky Nadia , Mar Kristie , Liu Chaocheng , Rivers Jason K , Mukovozov Ilya 
Published: October 2023

ZusammenfassungDie klinische Fotografie ist essentiell für die Dermatologie. Es gibt jedoch keine umfassende Aufarbeitung der Literatur zur Fotografie in der Dermatologie. Dieser Scoping Review soll die Literatur zu fotografischen Praktiken in der Dermatologie, der Fotografie stark pigmentierter Haut (Skin of Color), Patientenpräferenzen und medizinisch‐rechtlichen Überlegungen zusammenfassen. Die Datenbanken Embase, MEDLINE, PubMed und Evidence Based Medicine wurden im Einklang mit der PRISMA‐Erweiterung für Scoping Reviews durchsucht. Insgesamt wurden 33 Studien zusammengefasst. Die klinische Fotografie wird häufig für die Markierung von Biospiestellen, Beurteilung, Diagnostik, Krankheitsüberwachung, Bewertung des Ansprechens auf die Behandlung, medizinische Ausbildung, Forschung, das Einholen kollegialer Ratschläge und in der Teledermatologie eingesetzt. Obwohl es in der dermatologischen Fotografie weiterhin kaum Darstellungen von Skin of Color gibt, sind fotografische Überlegungen für dunklere Hauttypen verfügbar. Die meisten Patienten unterstützen die medizinische Fotografie. Dabei besteht der Wunsch, dass klinische Fotografien vom eigenen Arzt aufgenommen und bevorzugt klinikeigene Kameras und keine persönlichen Geräte verwendet werden. Relevante medizinisch‐rechtliche Fragestellungen umfassen Bedenken hinsichtlich des Datenschutzes, der Verwendung persönlicher Geräte und der Dokumentation der Einwilligung. Die Fotografie in der Dermatologie entwickelt sich ständig weiter und findet immer breitere Anwendung. Verbesserte Verfahren und Innovationen werden Menschen aller Hautfarben zugute kommen. Die Einhaltung der Zustimmung und des Datenschutzes muss gewährleistet werden, um die zunehmende Einfachheit der Bildaufnahme und ‐freigabe aufrechtzuerhalten.
Pemphigus‐ und Pemphigoid‐Erkrankungen: Klinik, Diagnostik und Therapie
Authors: Didona Dario , Schmidt Morna F. , Maglie Roberto , Solimani Farzan 
Published: October 2023

ZusammenfassungPemphigus und Pemphigoid sind seltene Autoimmunkrankheiten der Haut mit potenziell lebensbedrohlichem Verlauf. Autoantikörper gegen epidermale und junktionale Strukturproteine (Desmosomen sowie Hemidesmosomen) führen bei Betroffenen typischerweise zu juckenden, schmerzhaften Plaques oder Blasen an der Haut und/oder Blasenbildung und Erosionen der Schleimhäute mit möglicher Einschränkung der Lebensqualität. Seit der bahnbrechenden Arbeit von Walter Lever im Jahr 1953, dem es gelang, mittels histopathologischer Untersuchung diese beiden Krankheitsgruppen anhand des Musters der Antikörper‐vermittelten Blasenbildung zu differenzieren, wurden enorme Fortschritte im Verständnis der Erkrankungen erzielt. Die Errungenschaften in der Labordiagnostik ermöglichten die Identifikation von Zielstrukturen zur präzisen Unterscheidung verschiedener Varianten der bullösen Autoimmunerkrankungen. Diese Fortschritte gingen dank der Entwicklung von Tiermodellen mit einem besseren Verständnis der Pathogenese einher. Außerdem haben Studien an Haut und Blut betroffener Patienten zu neuen und krankheitsspezifischen Behandlungen geführt. Aufgrund ihrer Seltenheit und der klinischen Ähnlichkeit mit anderen dermatologischen Erkrankungen verzögern sich die korrekte Diagnosestellung und die Einleitung einer entsprechenden Therapie häufig, was in einigen Fällen zu irreversiblen Folgeerscheinungen, einschließlich Funktionsstörungen von Organen (zum Beispiel Verlust des Sehvermögens beim Schleimhautpemphigoid) führt. Wir geben hier einen Überblick über das klinische Erscheinungsbild, den Diagnosealgorithmus und das therapeutische Management von Pemphigus‐ und Pemphigoid‐Erkrankungen.
Unveiling empathy: Transforming child neurodisability in the Brazilian context of poverty and violence
Authors: dos Santos Gleidna Nascimento , Lima‐Costa Ariela Raissa , Otoni Fernanda , Veiga Heila Magali da Silva , Peres Rodrigo Sanches , Azevedo Adriano Valério , Antunes Maria Cristina , Bonfá‐Araujo Bruno , Cortez Pedro Afonso 
Published: October 2023

This letter to the editor is on the original article by Dorris et al. The article is available at https://doi.org/10.1111/dmcn.15263Portuguese translation of this letter to the editor is available in the online issue.
Participation of lncRNAs in the development of diabetic complications: Systematic review and meta‐analysis. I. Rat
Authors: Cabrera‐Najera Leonardo‐Elias , Chirino‐Galindo Gladys , Palomar‐Morales Martín 
Published: October 2023

AbstractAimsWe evaluated the involvement of lncRNAs in the development of pathologies associated with chronic hyperglycaemia in rat models in a model of type 1, type 2 and gestational diabetes.MethodsReports were searched in Dialnet, Scielo, HINARI, Springer, ClinicalKey, OTseeker, PubMed and different grey literature databases with any restrictions. Bibliography databases will be searched from their inception to December 2022.ResultsThirty‐seven studies met our criteria, and they had the following characteristics: original experimental studies on diabetes, the lncRNAs were extracted or measured from tissues of specific areas and the results were expressed in terms of standard measures by RT‐PCR. In most studies, both primary and secondary outcomes were mentioned. On the other hand, we found a total of nine diabetic complications, being retinopathy, nephropathy and neuropathy the most representatives. Additionally, it was found that MALAT1, H19, NEAT1 and TUG1 are the most studied lncRNAs about these complications in rats. On the other hand, the lncRNAs with the highest rate of change were MSTRG.1662 (17.85; 13.78, 21.93), ENSRNOT00000093120_Aox3 (7.13; 5.95, 8.31) and NONRATG013497.2 (−5.55; −7.18, −3.93).ConclusionsThis review found a significant involvement of lncRNAs in the progression of pathologies associated with chronic hyperglycaemia in rat models, and further studies are needed to establish their potential as biomarkers and therapeutic targets for diabetes.
Clinical competency development with handmade simulator in highly realistic paediatric dentistry scenarios
Authors: Bartolomé Villar Begoña , de la Hoz Calvo Ana , Torres Moreta Luz , Coro‐Montanet Gleyvis 
Published: October 2023

AbstractIntroductionThe use of simulation is extremely useful in pregraduate students. However, there is a very small number of simulators adapted to paediatric dentistry. A paediatric simulator was created to use in simulated scenarios for paediatric dentistry using an actress in the role of mother. The objectives of the present study were three. First, to analyse the perception of clinical competencies acquired by the students. Second, to examine the realism perceived by the students. Finally, to analyse the influence on the perception of clinical competencies after the integration of a handmade simulator in the Paediatric Dentistry III course.Materials and MethodsEight clinical scenarios were carried out with a modified Erler Zimmer simulator for children, a professional actress in the role of the mother and two students (in the roles of dentist and assistant) on a paediatric dentistry case of pulpal pathology. The educational intervention was evaluated on 114 students by means of questionnaires with Likert‐type answers applied pre‐ and post‐simulation.ResultsThe perception of clinical competence in the students increased an average of 0.956 points in relation with the initial clinical evaluation, finding a strong correlation between the perception of subsequent competence and all the perceived realism, with significant statistical differences in all cases. The realism of the simulated participant (professional actress) was the best rated by the students, although not significantly. The realism of the mannequin was positively and strongly correlated with the perceived realism of the cabinet.ConclusionSimulation using a handmade mannequin with a professional actress in a simulated dental office increased the perception of clinical competence in 4th year dental students and raised the level of overall realism perceived by the student.
Dental students' perceptions of simultaneous live and online OSCEs during the COVID‐19 pandemic
Authors: Tuononen Tiina , Karaharju‐Suvanto Terhi , Lahti Satu , Hytönen Hanna , Näpänkangas Ritva 
Published: October 2023

AbstractIntroductionThe Objective Structured Clinical Examination (OSCE) is a valid, reliable and reproducible assessment method traditionally carried out as a live examination but recently also provided online. The aim was to compare any differences in the perceptions of dental students participating in online and live OSCE using mixed methods.Materials and MethodsAll Finnish fourth‐year undergraduate dental students (n = 172) attended the exam in April 2021. Due to the COVID‐19 pandemic, the official administrative restrictions in teaching in universities still existed in April 2021. By the time of the national OSCE, the pandemic situation varied in different parts of the country. Therefore, two of the universities conducted a live OSCE and two an online version of the OSCE. Data were collected after the OSCE using a voluntary anonymous electronic questionnaire with multiple‐choice and open‐ended questions (response rate 58%). Differences between the OSCE versions were analysed using the Mann–Whitney U test and open answers with qualitative content analysis.ResultsThe students considered both types of OSCE good in general. The main differences were found concerned adequate time allocation and overall technical implementation, in favour of the live OSCE. While a qualitative analysis revealed exam anxiety as the most often mentioned negative issue, overall, comments were positive.ConclusionVariation in the assessments between different question entities seemed to be wider than between the implemented OSCE versions. Time management in the OSCE should be further developed by managing the assignment of tasks.
Allogeneic hematopoetic stem cell transplant for patients with refractory T‐Cell lymphomas
Authors: Massoud Radwan , Naim Hassan , Klyuchnikov Evgeny , Janson Dietlinde , Wolschke Christine , Ayuk Francis , Kröger Nicolaus 
Published: October 2023

AbstractObjectiveAllogeneic stem cell transplantation (allo‐SCT) may have a curative potential due to the graft versus lymphoma effect. In this study, we aimed to compare transplant outcomes between refractory‐T‐NHL (ref‐NHL) and Chemosensitive‐T‐NHL (CS‐T‐NHL).Materials and MethodsWe retrospectively reviewed the records of 26 ref‐NHL and 29 CS‐T‐NHL consecutive patients who underwent allo‐SCT at our center and compared the transplant outcomes between the groups.ResultsAll patients were heavily pretreated with 27% of patients relapsing post‐auto‐SCT and two patients in the ref‐T‐NHL post‐allo‐SCT. Patients were transplanted mainly from unrelated donors. There were no differences in leucocytes and platelet engraftment between the two groups. At 3 years, the relapse incidence was 34% in Ref‐TNHL and 19% in CS‐TNHL (p = .33), with non‐relapse mortality rates of 28% and 22%, respectively (p = .52). Female patients and those with a previous auto‐SCT had lower relapse incidence (p = .045, p = .003). The 3‐year overall survival was 39% in Ref‐TNHL and 56% in CS‐TNHL (p = .15). Trends for improved progression‐free survival (PFS) and graft‐versus‐host disease relapse‐free survival (GRFS) were observed in the CS‐TNHL group (PFS: 60% vs. 30%, p = .075; GRFS: 38% vs. 21%, p = .1).ConclusionAcknowledging the retrospective nature of our study, our results indicate that allo‐SCT has a curative potential in patients with T‐NHL even in refractory status.
Diversity loss from multiple interacting disturbances is regime‐dependent
Authors: Lear Luke , Inamine Hidetoshi , Shea Katriona , Buckling Angus 
Published: October 2023

AbstractAnthropogenic activities expose many ecosystems to multiple novel disturbances simultaneously. Despite this, how biodiversity responds to simultaneous disturbances remains unclear, with conflicting empirical results on their interactive effects. Here, we experimentally test how one disturbance (an invasive species) affects the diversity of a community over multiple levels of another disturbance regime (pulse mortality). Specifically, we invade stably coexisting bacterial communities under four different pulse frequencies, and compare their final resident diversity to uninvaded communities under the same pulse mortality regimes. Our experiment shows that the disturbances synergistically interact, such that the invader significantly reduces resident diversity at high pulse frequency, but not at low. This work therefore highlights the need to study simultaneous disturbance effects over multiple disturbance regimes as well as to carefully document unmanipulated disturbances, and may help explain the conflicting results seen in previous multiple‐disturbance work.
Upscaling the effect of traits in response to drought: The relative importance of safety–efficiency and acquisitive–conservation functional axes
Authors: Umaña María Natalia , Salgado‐Negret Beatriz , Norden Natalia , Salinas Viviana , Garzón Fabián , Medina Sandra P. , Rodríguez‐M. Gina M. , López‐Camacho René , Castaño‐Naranjo Alejandro , Cuadros Hermes , Franke‐Ante Rebeca , Avella Andrés , Idárraga‐Piedrahita Álvaro , Jurado Rubén , Nieto Jhon , Pizano Camila , Torres Alba M. , García Hernando , González‐M. Roy 
Published: October 2023

AbstractWe tested the idea that functional trade‐offs that underlie species tolerance to drought drive shifts in community composition via their effects on demographic processes and subsequently on shifts in species' abundance. Using data from 298 tree species from tropical dry forests during the extreme ENSO‐2015, we scaled‐up the effects of trait trade‐offs from individuals to communities. Conservative wood and leaf traits favoured slow tree growth, increased tree survival and positively impacted species abundance and dominance at the community‐level. Safe hydraulic traits, on the other hand, were related to demography but did not affect species abundance and communities. The persistent effects of the conservative–acquisitive trade‐off across organizational levels is promising for generalization and predictability of tree communities. However, the safety–efficient trade‐off showed more intricate effects on performance. Our results demonstrated the complex pathways in which traits scale up to communities, highlighting the importance of considering a wide range of traits and performance processes.
Progression of brain cholinergic dysfunction in patients with isolated rapid eye movement sleep behavior disorder
Authors: Stær Kristian , Iranzo Alex , Terkelsen Miriam Højholt , Stokholm Morten Gersel , Danielsen Erik Hvid , Østergaard Karen , Serradell Mónica , Otto Marit , Svendsen Kristina B. , Garrido Alicia , Vilas Dolores , Santamaria Joan , Møller Arne , Gaig Carles , Brooks David J. , Borghammer Per , Tolosa Eduardo , Pavese Nicola 
Published: October 2023

AbstractBackgroundReduced cortical acetylcholinesterase activity, as measured by 11C‐donepezil positron emission tomography (PET), has been reported in patients with isolated rapid eye movement (REM) sleep behavior disorder (iRBD). However, its progression and clinical implications have not been fully investigated. Here, we explored the relationship between longitudinal changes in brain acetylcholinesterase activity and cognitive function in iRBD.MethodsTwelve iRBD patients underwent 11C‐donepezil PET at baseline and after 3 years. PET images were interrogated with statistical parametric mapping (SPM) and a regions of interest (ROI) approach. Clinical progression was assessed with the Movement Disorder Society‐Unified Parkinson's Disease Rating Scale‐Part III (MDS‐UPDRS‐III). Cognitive function was rated using the Mini‐Mental State Examination (MMSE) and the Montreal Cognitive Assessment (MoCA).ResultsFrom baseline to follow‐up, the mean 11C‐donepezil distribution volume ratio (DVR) decreased in the cortex (p = 0.006), thalamus (p = 0.013), and caudate (p = 0.013) ROI. Despite no significant changes in the group mean MMSE or MoCA scores being observed, individually, seven patients showed a decline in their scores on these cognitive tests. Subgroup analysis showed that only the subgroup of patients with a decline in cognitive scores had a significant reduction in mean cortical 11C‐donepezil DVR.ConclusionsOur results show that severity of brain cholinergic dysfunction in iRBD patients increases significantly over 3 years, and those changes are more severe in those with a decline in cognitive test scores.
Equine allogeneic tenogenic primed mesenchymal stem cells: A clinical field study in horses suffering from naturally occurring superficial digital flexor tendon and suspensory ligament injuries
Authors: Carlier Stephanie , Depuydt Eva , Suls Marc , Bocqué Cedric , Thys Justine , Vandenberghe Aurélie , Martens Ann , Saunders Jimmy , Hellmann Klaus , Braun Gabriele , Beerts Charlotte , Spaas Jan H. 
Published: October 2023

AbstractBackgroundMesenchymal stem cells are an innovative therapeutic for various equine orthopaedic diseases, including soft tissue injuries.ObjectivesTo evaluate the safety and efficacy of tenogenic primed equine allogeneic peripheral blood‐derived mesenchymal stem cells (tpMSCs) in horses with naturally occurring superficial digital flexor tendon (SDFT) and suspensory ligament (SL) injuries.Study designMulticentre, blinded, randomised, placebo‐controlled clinical trial.MethodsOne hundred client‐owned horses with SDFT and SL injuries were randomised to receive an intralesional tpMSC (66) or saline (34) injection. Clinical and ultrasonographic evaluation was performed before treatment and on Days 56 ± 3 and 112 ± 3 after treatment. Long‐term data on re‐injury was collected up to 2 years after treatment.ResultsSignificantly more tpMSC‐treated horses achieved improvement in fibre alignment score (FAS) (100% vs. 54.5%, p < 0.001) and echogenicity (97.0% vs. 57.6%, p < 0.001) on Day 112 ± 3, and their lesion size decreased significantly (−27.6 ± 25.91 vs. −4.6 ± 26.64 mm2, p < 0.001) compared to the placebo group. A FAS = 0 was achieved in 65% of tpMSC‐treated horses, as compared to 9% of placebo‐treated horses at Day 112 ± 3. The attending veterinarians reported no re‐injury in 41 of 53 tpMSC and in 2 of 26 saline‐treated horses available for long‐term follow‐up (p < 0.001).Main limitationsAs this study consisted of client‐owned horses, no samples for histology were collected. Long‐term follow‐up was only available for a subset of enrolled horses.ConclusionsThe intralesional administration of tpMSCs was safe and improved the quality of healing and long‐term outcomes in sports horses with naturally occurring SDFT and suspensory injuries.