bluuebunny/crossref_metadata_2025_split huggingface dataset:
Aversive agents: Think twice. A case report on disulfiram‐induced mania
Authors: González‐Romero María Fernanda , Martínez‐Ávila José María , Moloney Elizabeth , García‐Cabeza Ignacio 
Published: November 2023

AbstractWe present a case of disulfiram‐induced mania in a patient with both alcohol use disorder (AUD) and psychostimulant use disorder (PUD), without a history of psychosis or mania. This acute presentation may be linked to the increased dopamine levels caused by disulfiram metabolism. Our patient developed manic symptoms 10 days after starting disulfiram, prescribed to treat the AUD. It should be noted that the symptoms resolved rapidly after disulfiram cessation during hospitalization. Disulfiram use is an effective treatment for alcohol dependence. However, there are safety concerns associated with it and it requires close monitoring, particularly in patients with a history of mania, psychosis, or psychostimulant use.
Does second‐generation involvement promote family firm environmental investment? The China experience
Authors: Fu Ying , Jiang Lei , Bo Qiushi , Kang Ning 
Published: November 2023

AbstractFamily firms not only play an important role in economic growth but should also be held partly responsible for environmental degradation. Employing normative stakeholder theory and analyzing unique Chinese survey data via stepwise regression models, our findings indicate that second‐generation successors did not significantly impact family firms' environmental investment. However, among second‐generation successors, we find that successors with international experience positively impacted environmental investment. The propensity score matching (PSM) and two‐stage least squares estimation (2SLS) approaches confirm our results. As an interdisciplinary study, our research is of great value to the environmental responsibility and family business literature.
Past, present and future revitalization trends in Canadian mid‐size city downtowns
Authors: Filion Pierre 
Published: November 2023

ABSTRACTThe article is a critical review of the literature investigating the impact suburbanization has had since the mid‐20th century on the downtowns of Canadian mid‐size cities and the strategies deployed to revitalize these districts. It demonstrates that large city downtowns are more likely than their mid‐size city counterparts to enjoy conditions favourable to their success, hence the need to devise revitalization efforts tailored to the reality of mid‐size city downtowns. The article identifies revitalization strategies adopted over the last decades, which mostly failed to reverse the decline affecting these downtowns. It then concentrates on the present, and likely enduring, revitalization model, which emphasizes hospitality, recreation, culture, services, and walkability. The article refines the understanding of the differences between mid‐size and large city downtowns by concentrating on their specific dynamics and explores future revitalization options for mid‐size city downtowns. It discusses the present and likely enduring absence of alternatives to the present revitalization model and highlights its equity downsides as it challenges the downtown low‐income resident living environment.
Fathers with intellectual disabilities raising children with disabilities in Poland: An interpretive phenomenological analysis
Authors: Ćwirynkało Katarzyna , Parchomiuk Monika , Fronek Patricia 
Published: November 2023

AbstractResearch on parents with intellectual disabilities and their children tends to focus on individual risk and those factors associated with child maltreatment. Interviews and Interpretative Phenomenological Analysis was used to explore the lived experience of 10 Polish fathers with intellectual disabilities raising children with disabilities. Three main themes emerged: (1) everybody's got something, (2) on being a father, and (3) finding meaning. The findings indicated that participants focused on strengths rather than disability diagnoses. They did recognize that they experienced various challenges associated with managing some behaviours, meeting educational, health and disability needs, and that additional support was helpful. Fathers also faced socioeconomic disadvantage, limited employment opportunities, and communication difficulties with schools, bureaucracies and services, and a lack of understanding by some professionals including teachers. Fathers appreciated the support their children received. All fathers found meaning in their unique experiences of fatherhood through mutual affection and their children's successes. Recommendations for practice and future research are discussed.
The role of parental aggravation in the intergenerational transmission of depression across different family structures
Authors: Park Yangjin , Thor Pa , Yang Sejung 
Published: November 2023

AbstractThis study examined the role of parental aggravation in the pathway from maternal depression to child depression in different family structures. While studies have extensively examined the transmission of maternal depressive symptoms to children, there is still a limited emphasis on potential contributors, such as parental aggravation. Meanwhile, cohabiting and single‐parent families are more vulnerable to multiple risk factors than married families. Using a large national longitudinal dataset, this study examined the indirect effect of parental aggravation on the association between maternal depression and child depression among married, cohabiting and single‐mother families. Secondary data analysis was performed using multigroup mediation analysis on three waves from the Future of Families and Child Wellbeing Studies (n = 3 117). The study results show that only in cohabiting households did maternal depression have a direct association with child depression. Furthermore, in married, cohabiting and single‐mother families, parental aggravation had indirect effects on the association between maternal depression and child depression. Implications for social work professionals to address the mental health of parents and children from non‐traditional families are discussed.
Peri‐implant health after microvascular head and neck reconstruction—A retrospective analysis
Authors: Hoffmann Korbinian Jochen , Büsch Christopher , Moratin Julius , Ristow Oliver , Hoffmann Jürgen , Mertens Christian 
Published: November 2023

AbstractIntroductionProsthodontic rehabilitation after reconstruction with microvascular revascularized free flaps following ablative tumor surgery is challenging due to the altered anatomical and functional conditions. The aim of this retrospective study was to determine whether the type of graft and the type of peri‐implant tissue have an effect on peri‐implant inflammatory parameters and implant survival.Materials and MethodsPatients who received a free flap reconstruction with subsequent implant‐prosthetic rehabilitation between 2010 and 2022 were retrospectively included. The primary outcome variable was the probing depth (PPD) at a minimum of 1 year after completion of prosthetic restoration. Predictive variables were type of free flap, emergence profile, and history of radiation.ResultsSeventy‐one patients after free flap reconstruction were included in the analysis. At a minimum of 24 months after implant insertion the primary outcome, PPD showed no clinically relevant differences between the types of free flaps used. The emergence profile through a skin island resulted in an increase in BOP compared to native mucosa in the descriptive analysis (p‐value > .05). The analysis showed a 5‐year implant survival of 96.2% (95% CI: 0.929–0.996) in cases without irradiation and 87.6% (95% CI: 0.810–0.948) with irradiation of the region evaluated (p‐value .034).ConclusionFlap and associated soft tissue type had no significant effect on 5‐year implant survival or peri‐implant inflammatory parameters. However, the large heterogeneity of the patient population indicates that further prolonged studies are required for a more differentiated assessment of the long‐term success.
Epigallocatechin‐3‐gallate improves the quality of maternally aged oocytes
Authors: Zhang HongHui , Su Wei , Zhao RuSong , Li Mei , Zhao ShiGang , Chen Zi‐Jiang , Zhao Han 
Published: November 2023

AbstractThe decline in female fertility as age advances is intricately linked to the diminished developmental potential of oocytes. Despite this challenge, the strategies available to enhance the quality of aged oocytes remain limited. Epigallocatechin‐3‐gallate (EGCG), characterised by its anti‐inflammatory, antioxidant and tissue protective properties, holds promise as a candidate for improving the quality of maternally aged oocytes. In this study, we explored the precise impact and underlying mechanisms of EGCG on aged oocytes. EGCG exhibited the capacity to enhance the quality of aged oocytes both in vitro and in vivo. Specifically, the application of EGCG in vitro resulted in noteworthy improvements, including an increased rate of first polar body extrusion, enhanced mitochondrial function, refined spindle morphology and a reduction in oxidative stress. These beneficial effects were further validated by the improved fertility observed among aged mice. In addition, our findings propose that EGCG might augment the expression of Arf6. This augmentation, in turn, contributes to the assembly of spindle‐associated F‐actin, which can contribute to mitigate the aneuploidy induced by the disruption of spindle F‐actin within aged oocytes. This work thus contributes not only to understanding the role of EGCG in bolstering oocyte health, but also underscores its potential as a therapeutic intervention to address fertility challenges associated with advanced age.
Feasibility of preemptive pharmacogenetic testing and improvement of medication treatment satisfaction among medically underserved patients
Authors: Lteif Christelle , Eddy Elizabeth , Terrell Joshua , Cavallari Larisa H. , Malaty John , Duarte Julio D. 
Published: November 2023

AbstractPrevious findings suggest that medically underserved patients are prescribed medications with pharmacogenetic (PGx) guidelines at a high frequency. Thus, underserved patients may especially benefit from PGx testing, but little evidence exists regarding the effect of testing in this population. This pilot study aimed to generate key feasibility data and explore clinical outcomes of PGx implementation in underserved populations. Black and Latino patients were recruited from an outpatient clinic and underwent PGx testing. Feasibility measures included enrollment metrics and actionable genotype frequencies. The primary clinical outcome was patient medication treatment satisfaction 6 months after testing. Implementation outcomes included the number of healthcare provider encounters and medication changes within the 6‐month follow‐up. Effectiveness outcomes included medication adherence, patient‐perceived test value, and time spent discussing medications with providers. Ninety‐nine patients completed the study. Proton‐pump inhibitors were the most frequent PGx drug class prescribed at baseline (61%) followed by nonsteroidal anti‐inflammatory drugs (36%). Patients with an actionable genotype constituted 96% of the population, whereas 28% had an actionable genotype related to their PGx drug. Patient treatment satisfaction significantly increased over the 6 months after PGx testing. In addition, medication adherence and the number of provider encounters significantly increased over the study period. In a pilot study, preemptive PGx testing was feasible in primary care clinics, improved patient treatment satisfaction and adherence, and increased the number of provider encounters in medically underserved patients. Future clinical trials are warranted to assess the long‐term effects of PGx testing in a larger diverse patient population.
‘The convenience is a double‐edged sword’: Qualitative interviews with people who use online alcohol delivery services
Authors: Colbert Stephanie , Thornton Louise , Wilkinson Claire , Feng Xiaoqi , Richmond Robyn 
Published: November 2023

AbstractIntroductionThe past decade has seen a shift towards online purchasing and home delivery of alcohol, with this trend accelerated due to the COVID‐19 pandemic. However, research in this area is limited. This study aims to explore how and why people use online alcohol delivery services.MethodsSemi‐structured qualitative interviews (mean = 12.5 min; range = 7–19.5 min) with a convenience sample of 40 Australians ≥18 years who purchase alcohol online for delivery at least once per month. Reflexive thematic analysis was used to analyse and report the data.ResultsThree themes were generated. (i) The convenience is a ‘double‐edged sword’: almost all participants expressed that they use alcohol delivery services because they reduce difficulty in obtaining alcohol by saving time or energy/effort; however, for some this could lead them to purchase and consume more alcohol than they otherwise would have. (ii) Cost savings motivate online purchases: some participants expressed that they could access alcohol more cheaply online than in‐store due to promotions, cost‐comparisons and the ability to shop at low‐cost outlets. (iii) Initiating or increasing use during the COVID‐19 pandemic: for some people continued or increased use had been maintained as they had grown accustomed to the convenience or changed shopping habits.Discussion and ConclusionParticipants purchased alcohol online for home delivery primarily for convenience; however, for some the convenience could lead them to purchase and consume more alcohol than they otherwise would have. Targeted improvements to the regulation of these services are needed to minimise the risks they may pose for alcohol harm.
Endoscopic evaluation of indeterminate biliary strictures: Cholangioscopy, endoscopic ultrasound, or both?
Authors: Tang Raymond S. Y. 
Published: November 2023

Accurate and timely diagnosis of biliary strictures can be challenging. Because the diagnostic sensitivity and accuracy of standard endoscopic retrograde cholangiopancreatography‐based tissue sampling for malignancy are suboptimal, additional endoscopic evaluation by cholangioscopy and/or endoscopic ultrasound (EUS) is often necessary to differentiate between malignant and benign biliary strictures to guide clinical management. While direct visualization by cholangioscopy and/or high‐resolution imaging by EUS are often the first step in the evaluation of an indeterminate biliary stricture (IDBS), tissue diagnosis by cholangioscopy‐guided biopsy and/or EUS‐guided fine‐needle tissue acquisition is the preferred modality to establish a diagnosis of malignancy. Because each modality has its own strengths and limitations, selection of cholangioscopy and EUS is best guided by the biliary stricture location and local expertise. Artificial intelligence‐assisted diagnosis, biopsy forceps with improved design, contrast‐enhanced EUS, and dedicated fine‐needle biopsy devices are recent technological advances that may further improve the diagnostic performance of cholangioscopy and EUS in patients with IDBS.
How co‐design can localize development programmes and reduce dependency: Examples from Pacific Island Countries
Authors: Devi Artila 
Published: November 2023

AbstractMotivationInternational donors commit around USD 2 billion every year to Pacific Island Countries (PICs). While the donors intend to help develop the Pacific, few of the projects they fund involve any more local involvement in their selection and planning beyond consultation with selected, often elite, or small groups of locals. It is even rarer to find projects that are localized or locally‐led.PurposeWe ask whether it is possible to do more to localize donor‐funded development in the Pacific. We ask if co‐design between foreign and local specialists can localize development, by giving locals more agency, and by prioritizing indigenous knowledge.Specifically, we review the Pacific eLearning Programme (PeP), funded by New Zealand and implemented in the Cook Islands, Samoa, Solomon Islands and Vanuatu. The programme works with Ministries of Education to design science content that reflects the country context for some ten or so schools in each nation. Co‐design includes use of indigenous dialogue [talanoa / tok stori / storian] to share, debate and learn between foreign and local specialists, and between specialists across the four countries.Methods and approachEvidence was gathered from pre‐ and post‐programme surveys. Further data was collected from comments written by the local co‐designers.FindingsWe found that kinship formed between locals and foreigners, based on mutual respect for the knowledge each group brought. This process empowered locals, valued their expertize and knowledge, and reduced dependency by prioritizing indigenous and local knowledge. Localization led to mutually beneficial outcomes.Policy implicationsCreation and implementation of policies that mandate localization through recruitment, use of indigenous methodologies, co‐design and recognition of local skills, knowledge and culture will help create trust with development partners, empower locals, exchange skills and knowledge between locals and foreigners, and reduce dependency.
Is there any robust evidence showing that SGLT2 inhibitor predisposes to cancer?
Authors: Copur Sidar , Yildiz Abdullah B. , Covic Adrian , Kanbay Mehmet 
Published: November 2023

AbstractBackgroundThe exact pathophysiological mechanisms of SGLT‐2 inhibitors in the development, progression or treatment of malignancies are not fully understood, but multiple hypotheses have been proposed. SGLT‐2 inhibitors have potential anti‐proliferative roles due to several underlying pathophysiological mechanisms, such as inhibition of ATP production, activation of AMPK signalling, induction of apoptosis and ferroptosis, inhibition of glutamate dehydrogenase activity and inhibition of DNA and RNA synthesis. However, heterogeneity among tumour cells and SGLT‐2 inhibitor drugs limit the generalizability of pre‐clinical studies.MethodsThis is a narrative review discussing the potential anti‐cancer effects of SGLT‐2 inhibitors, an oral glucose‐lowering medication used in patients with type II diabetes mellitus. This review discusses underlying mechanisms, pre‐clinical and clinical trial data, epidemiological data and future perspectives on the use of SGLT‐2 inhibitors in cancer treatment.ResultsType II diabetes is linked to various comorbidities and malignancies, but some glucose‐slowering medications may have a preventive role in cancer. The use of SGLT‐2 inhibitors was associated with bladder cancer based on mice studies. However, meta‐analyses showed no significant increase in overall malignancy incidence of any specific type, except for empagliflozin and bladder cancer association. SGLT‐2 inhibitors can potentially reduce the heart damage caused by doxorubicin and sunitinib, while enhancing the anti‐cancer effects of doxorubicin. Combining SGLT‐2 inhibitors with doxorubicin may allow higher doses of chemotherapy use. Multiple ongoing clinical trials are investigating the potential therapeutic potential of SGLT‐2 inhibitors in various types of cancer.ConclusionMore large‐scale pre‐clinical and clinical studies are needed to explore their potential preventive and therapeutic roles of SGLT‐2 inhibitors in cancer treatment. In this narrative review, our aim is to explore the pre‐clinical and clinical data regarding the potential anti‐cancer effects of SGLT‐2 inhibitors including the hypothetical pathophysiological mechanisms.
A comparison of live versus kill pitfall traps to assess the diet of carabids through a metabarcoding approach
Authors: Graux Yohann , Querejeta Marina , Gaba Sabrina , Bretagnolle Vincent , Boyer Stéphane 
Published: November 2023

AbstractMetabarcoding approaches are powerful tools to unravel trophic relationships between predators and prey. To apply metabarcoding analyses on invertebrate gut contents, specimens must be well preserved from DNA degradation, thus the trapping method should be selected accordingly. Dry pitfall traps are commonly assumed to provide a better DNA preservation than traps that use a killing agent. However, this assumption has never been specifically tested for gut content analyses. In our study, we compared how two types of pitfall trapping, dry vs. with brine, affect the conservation of prey DNA contained in the digestive tract of predators and subsequent metabarcoding analyses. We placed dry and ‘classic’ pitfall traps in oilseed rape fields within an intensive agricultural area in the French Nouvelle‐Aquitaine region. Traps were set up in autumn and compared for carabid trapping efficiency as well as our capacity to retrieve dietary information from the digestive tract of the main carabid species, Nebria salina (Fairmaire & Laboulbène) and Calathus fuscipes (Goeze) (both Coleoptera: Carabidae). The PCR success rate was higher in dry pitfall traps compared to classic ones for N. salina. We hypothesise that this was due to the presence of PCR inhibitors in the gut of this species. The ability to sequence prey DNA did not differ between specimens caught in both trap types. The list of preyed species was similar between both trap types. However, sequencing yielded more prey operational taxonomic units (OTUs) from specimens caught in dry pitfall traps, leading to differences in prey community composition and a greater ability to reconstruct prey community. Our analyses also shed light on the prey spectrum of C. fuscipes and N. salina in oilseed rape in autumn.
Cortical synaptic basis of consciousness
Authors: Zhuo Min 
Published: November 2023

AbstractConsciousness is one of final questions for humans to tackle in neuroscience. Due to a lack of understanding of basic brain networks and mechanisms of functions, our knowledge of consciousness mainly stays at a theoretical level. Recent studies using brain imaging in humans and modern neuroscience techniques in animal studies reveal the basic brain network for consciousness. The projection from the thalamus to different cortical regions forms a network of activities to maintain consciousness in humans and animals. These feedback and feedforward circuits maintain consciousness even in certain brain injury conditions. Pterions and ion channels that contribute to these circuit neural activities are targets for drugs and manipulations that affect consciousness such as anesthetic agents. Synaptic plasticity that trains synapses during learning and information recall modified the circuits and contributes to a high level of consciousness in a certain population.