bluuebunny/crossref_metadata_2025_split huggingface dataset:
Intraosseous regional prophylaxis in total knee arthroplasty
Authors: Young Simon W. , Chen William , Clarke Henry D. , Spangehl Mark J. 
Published: November 2023

Prophylactic antibiotics are important in reducing the risk of periprosthetic joint infection (PJI) following total knee arthroplasty. Their effectiveness depends on the choice of antibiotic and the optimum timing of their administration, to ensure adequate tissue concentrations. Cephalosporins are typically used, but an increasing number of resistant organisms are causing PJI, leading to the additional use of vancomycin. There are difficulties, however, with the systemic administration of vancomycin including its optimal timing, due to the need for prolonged administration, and potential adverse reactions. Intraosseous regional administration distal to a tourniquet is an alternative and attractive mode of delivery due to the ease of obtaining intraosseous access. Many authors have reported the effectiveness of intraosseous prophylaxis in achieving higher concentrations of antibiotic in the tissues compared with intravenous administration, providing equal or enhanced prophylaxis while minimizing adverse effects. This annotation describes the technique of intraosseous administration of antibiotics and summarizes the relevant clinical literature to date.Cite this article: Bone Joint J 2023;105-B(11):1135–1139.
What is a tibial pilon fracture and how should they be acutely managed? A survey of consultant British Orthopaedic Foot and Ankle Society members and non-members
Authors: Hill DS , Davis JR 
Published: November 2023

Introduction Controversy exists around which distal tibial fractures are pilon fractures. We evaluated views to define a pilon fracture and support the development of standards of care. Methods Views regarding the characteristics of a pilon fracture and acute soft tissue management were determined through a questionnaire. This was trialled, approved by the British Orthopaedic Foot and Ankle Society and distributed to its members. This was also distributed nationally as part of the ENFORCE study. Results In total, 282 consultants from 27 units responded, of whom 24% (69/282) were foot and ankle specialists. Some 58% (163/282) agreed that a pilon fracture is primarily a soft tissue injury, 81% (228/282) that pilon fractures occur though high-energy transfer, 81% (228/282) that pilon fractures are sustained through an axial compression mechanism and 93% (265/282) that they are a potentially limb-threatening injury. Overall, 83% (234/282) agreed that in a length-unstable pilon fracture it is not possible to maintain the talus near anatomically under the tibial plafond without rigid fixation to control length – with 87% (246/282) agreeing that the acute first-line management should be a spanning external fixator. Opinions were that the time frame between diagnosis and intervention should be: less than 6h (63%; 154/246), 6–12h (31%; 77/246) and 12–24h (6%; 15/246). Conclusion Consensus supports defining a pilon fracture as a potentially limb-threatening high-energy axial compression injury, and a spanning external fixator as the first-line management of a length-unstable injury less than 12h from diagnosis.
Critically deviating vital signs among patients with non-specific diagnoses–A register-based historic cohort study
Authors: Sørensen Mia Carøe , Søvsø Morten Breinholt , Christensen Erika Frischknecht , Lindskou Tim Alex 
Published: November 2023

Background
One third of ambulance patients receive non-specific diagnoses in hospital. Mortality is 3–4%, however due to the high patient volume this group accounts for 20% of all deaths at day 30. Non-specific diagnoses do not provide much information on causes for death. Vital signs at first contact with ambulance personnel can act as a proxy for the patient’s condition. Thus, we aimed to describe the prevalence of abnormal vital signs, as determined by a modified NEWS2, in ambulance patients who received a non-specific hospital diagnosis. Secondly, we examined the association between vital signs, NEWS2 scores, type of non-specific diagnosis, and mortality among these patients.

Methods
Register-based historic cohort study of ambulance patients aged 16+ in the North Denmark Region during 2012–2016, who received a non-specific diagnosis (ICD-10 chapters R or Z) at hospital. We used NEWS2 scores to determine if first vital signs were normal or deviating (including critical). Mortality was estimated with the Kaplan-Meier estimator. Association between vital signs and mortality was evaluated by logistic regression.

Results
We included 41,539 patients, 20.9% (N = 8,691) had normal vital signs, 16.3% (N = 6,766) had incomplete vital sign registration, 62.8% (N = 26,082) had deviating vital signs, and of these 6.8% (N = 1,779) were critical. If vital signs were incompletely registered or deviating, mortality was higher compared to normal vital signs. Patients with critical vital signs displayed the highest crude 48-hour and 30-day mortality (7.0% (5.9–8.3) and 13.4% (11.9–15.1)). Adjusting for age, sex, and comorbidity did not change that pattern. Across all vital sign groups, despite severity, the most frequent diagnosis assigned was Z039 observation for suspected disease or condition unspecified.

Conclusions
Most ambulance patients with non-specific diagnoses had normal or non-critical deviating vital signs and low mortality. Around 4% had critical vital signs and high mortality, not explained by age or comorbidity.
Gene editing technologies used to reduce infectious plant diseases
Authors: Agarwal Chiti 
Published: November 2023

The most significant challenges to improving yield in agriculture science need progressive improvement with novel strategies. The modern gene editing scenario must focus on reducing the infectious plant diseases caused by plant pathogens. Targeted plant genome engineering enables optimal modifications in commercial plant varieties by incorporating effective alternative gene editing methods over other traditional approaches.
Genome editing technology is a multipurpose approach that rapidly progressed in plant biology to alter the phenotype and genotype of the species. Despite its advantages, traditional genome modification could not meet the recent demands for site-directed mutagenesis, high effectiveness, and retrofitting of artificial endonucleases
3. Current gene editing technologies have been subdivided into three kinds of cleavage systems, which are Transcription activator-like effector nucleases TALEN, Zinc Finger nucleases ZFN, CRISPR Cas (Clustered Regularly Interspaced Short Palindromic Repeats - CRISPR associated protein). These methods lead to single-stranded or double-stranded mutation through homologous recombination. Hence, this Review is motivated by the advantages of the gene editing tools in developing the plant immune system.
High-sensitivity computational miniaturized terahertz spectrometer using a plasmonic filter array and a modified multilayer residual CNN
Authors: Liu Mengjuan , Yang Meichen , Zhu Jiaqi , Zhu He , Wang Yao , Ren Ziyang , Zhai Yihui , Zhu Haiming , Shan Yufeng , Qi Hongxing , Duan Junli , Wu Huizhen , Dai Ning 
Published: November 2023

Abstract
Spectrometer miniaturization is desired for handheld and portable applications, yet nearly no miniaturized spectrometer is reported operating within terahertz (THz) waveband. Computational strategy, which can acquire incident spectral information through encoding and decoding it using optical devices and reconstruction algorithms, respectively, is widely employed in spectrometer miniaturization as artificial intelligence emerges. We demonstrate a computational miniaturized THz spectrometer, where a plasmonic filter array tailors the spectral response of a blocked-impurity-band detector. Besides, an adaptive deep-learning algorithm is proposed for spectral reconstructions with curbing the negative impact from the optical property of the filter array. Our spectrometer achieves modest spectral resolution (2.3 cm−1) compared with visible and infrared miniaturized spectrometers, outstanding sensitivity (e.g., signal-to-noise ratio, 6.4E6: 1) superior to common benchtop THz spectrometers. The combination of THz optical devices and reconstruction algorithms provides a route toward THz spectrometer miniaturization, and further extends the applicable sphere of the THz spectroscopy technique.
Crystal structure of Zn2[(1,1′-(hexane-1,6-diyl)bis(3-(pyridin-3-yl)urea))·(H2O)2·(DMF)2·(SO4)2], C24H50N8O18S2Zn2
Authors: Zhao Wen-Ze , Tian Hua 
Published: November 2023

Abstract
C24H50N8O18S2Zn2, triclinic, P1̄ (no. 2), a = 7.9797(5) Å, b = 10.4923(6) Å, c = 11.4835(7) Å, α = 97.512(2)°, β = 100.089(2)°, γ = 94.156(2)°, V = 933.98(10) Å3, Z = 1, R
gt(F) = 0.0382, wR
ref(F
2) = 0.1202, T = 293(2) K.
A Two-Stage Automatic System for Detection of Interictal Epileptiform Discharges from Scalp Electroencephalograms
Authors: Wang Xiaoyun , Wang Xing , Wang Chong , Wang Zhongyuan , Liu Xiangyu , Lv Xiaoling , Tang Ying 
Published: November 2023

AbstractThe objective of this work was to develop a deep learning-based automatic system with reliable performance in detecting interictal epileptiform discharges (IEDs) from scalp electroencephalograms (EEGs). For the present study, 484 raw scalp EEG recordings were included, standardized, and split into 406 for training and 78 for testing. Two neurophysiologists individually annotated the recordings for training in channel-wise manner. Annotations were divided into segments, on which nine deep neural networks (DNNs) were trained for the multiclassification of IED, artifact, and background. The fitted IED detectors were then evaluated on 78 EEG recordings with IED events fully annotated by three experts independently (majority agreement). A two montage-based decision mechanism (TMDM) was designed to determine whether an IED event occurred at a single time instant. Area under the precision–recall curve (AUPRC), as well as false-positive rates, F1 scores, and kappa agreement scores for sensitivity = 0.8 were estimated. In multitype classification, five DNNs provided one-versus-rest AUPRC mean value >0.993 using fivefold cross-validation. In IED detection, the system that had integrated the temporal convolutional network (TCN)-based IED detector and the TMDM rule achieved an AUPRC of 0.811. The false positive was 0.194/min (11.64/h), and the F1 score was 0.745. The agreement score between the system and the experts was 0.905. The proposed framework provides a TCN-based IED detector and a novel two montage-based determining mechanism that combined to make an automatic IED detection system. The system would be useful in aiding clinic EEG interpretation.
“Leader–Follower” Dynamic Perturbation Manipulates Multi-Item Working Memory in Humans
Authors: Huang Qiaoli , Luo Minghao , Mi Yuanyuan , Luo Huan 
Published: November 2023

AbstractManipulating working memory (WM) is a central yet challenging notion. Previous studies suggest that WM items with varied memory strengths reactivate at different latencies, supporting a time-based mechanism. Motivated by this view, here we developed a purely bottom-up “Leader–Follower” behavioral approach to manipulate WM in humans. Specifically, task-irrelevant flickering color disks that are bound to each of the memorized items are presented during the delay period, and the ongoing luminance sequences of the color disks follow a Leader–Follower relationship, that is, a hundreds of milliseconds temporal lag. We show that this dynamic behavioral approach leads to better memory performance for the item associated with the temporally advanced luminance sequence (Leader) than the item with the temporally lagged luminance sequence (Follower), yet with limited effectiveness. Together, our findings constitute evidence for the essential role of temporal dynamics in WM operation and offer a promising, noninvasive WM manipulation approach.
Value of circulating neutrophil elastase for detecting recurrence of differentiated thyroid cancer
Authors: Lee Hyunjae , Kim Tae-Shin , Gu Ja-Yoon , Yu Mi Ran , Lee Seung-Eun , Kim Eun Sook , Kim Hyun Kyung 
Published: November 2023

Objective
The inflammatory microenvironment has been implicated in differentiated thyroid cancer (DTC). Inflammatory stimuli induce the release of components of neutrophils into extracellular space, leading to formation of neutrophil extracellular trap (NET), which can stimulate growth and progression of cancer. Generation of activated factor XII and thrombin is also involved in cancer progression. This study attempted to determine whether the level of circulating markers of NET, activated factor XII, and endogenous thrombin potential may be useful for detecting the recurrence of DTC.

Methods
A total of 122 patients with DTC were recruited during the postoperative follow-up period. Measurement of the levels of circulating markers of NET (neutrophil elastase, histone–DNA complex, cell-free dsDNA), activated factor XII, and endogenous thrombin potential was performed.

Results
A significantly elevated level of neutrophil elastase was detected in patients with recurrence (n = 12) compared to those without recurrence (n = 110), while significant elevation of the levels of other markers was not observed. The value for area under the curve (0.717, P = 0.018) of neutrophil elastase for detecting recurrence of DTC was superior to that (0.661, P = 0.051) of serum thyroglobulin. An elevated level of neutrophil elastase was significantly associated with recurrence of DTC independent of serum thyroglobulin.

Conclusions
Because an elevated level of neutrophil elastase was detected in patients with recurrence of DTC and showed a significant association with recurrence of DTC, it can be proposed as a novel biomarker for use in detecting recurrence of DTC along with other tests.
Long-term spatiotemporal distribution, abundance, and priority areas for manatees and calves (Trichechus manatus Sirenia: Trichechidae) in Guatemala
Authors: Quintana-Rizzo Ester , Machuca-Coronado Oscar , Garcia Heidy Amely 
Published: November 2023

Introduction: The Antillean manatee (Trichechus manatus manatus) is an endangered species found throughout the Caribbean, and the coastal waters of Central and northeastern South America. Their low numbers are the result of a variety of human-related pressures. A small population of manatees has been identified in Guatemala; however, their spatial and temporal dynamics remain unclear.
Objective: To examine long-term trends in the spatiotemporal distribution and abundance of manatees in Guatemala. This included identification of priority areas for manatees including the presence of calves, assessing whether distribution areas are inside protected areas, and studying the relationship between manatee sightings and human activities.
Methods: Nine years of standardized aerial surveys were conducted along the Atlantic coast (1992, 2005-2008, 2010-2011, 2014, 2022). Quantitative approaches to detect priority areas, specifically the Kernel density estimation and the Getis-Ord Gi* statistic, were used in the spatiotemporal analysis. A Spearman rank correlation analysis tested for significant correlations between human activities, coastline topographies, and manatee numbers along coastline segments. Manatee abundance across years, survey sections, and protected areas were also examined.
Results: A total of 293 sightings and 518 manatees were observed including 476 adults (92 %) and 42 calves (8 %). Manatees were most frequently observed as solitary individuals (60 %). Most manatee (61 %) and calf (68 %) sightings occurred inside protected areas where several priority areas were identified. The two priority areas were Refugio de Vida Silvestre Bocas del Polochic (Bocas del Polochic) and Refugio de Vida Silvestre Punta de Manabique, which were identified as important manatee habitats in 1992. Bocas del Polochic had the highest manatee abundance of all protected areas (p < 0.05). However, a shift in manatee distribution was recorded in 2014, although the cause is unclear. No annual significant differences in manatee abundance were found over time (p = 1.0), but significant differences in abundance were detected between survey sections and protected areas (p < 0.05). Manatee numbers had positive significant correlations with ecological and human parameters. The highest correlation was between manatees and rivers (p < 0.01), and the weakest correlation was between manatees, motorboats, and fishing nets (p < 0.01).
Conclusions: The results indicate that the local manatee population remained relatively stable for over 20 years, although changes in overall distribution were noted. It is unclear if the changes are temporary or permanent. As a sentinel species, manatee distribution shifts can be used as early warnings about the health of the environment and can depict current or potential impacts on individual- and population-level animal health.
Southern Hemisphere humpback whales (Megaptera novaeangliae) (Artiodactyla: Balaenopteridae) singing activity at Caño Island Biological Reserve, Costa Rica before, during, and after COVID-19 lockdowns
Authors: May-Collado Laura J. , Bottoms Sawyer , Durant Grace , Palacios-Alfaro Jose David , Alvarado Juan Jose 
Published: November 2023

Introduction: Boat traffic is recognized as a major contributor of underwater noise. Increasing presence of boats in coastal habitats is predicted to have important repercussions on the communication of marine mammals. In Costa Rica, the waters of the Caño Island Biological Reserve are an important breeding area for humpback whales from the Breeding-Stock G (BSG). Their predicted and abundant presence has fueled the development of whale watching activities as an important component of the local economy, and while the country has norms of conduct for this activity, whales often interact with multiple boats at the same time. The lockdowns associated with the COVID-19 pandemic provided a unique opportunity to study the potential impacts of noise associated with boat traffic on the singing activity of humpback whales.
Objective: Determine whether noise levels and boat acoustic presence around Caño Island Biological Reserve changed during the COVID-19 lockdowns, and if it did, what is the impact on song detection of BSG humpback whales.
Methods: Acoustic recordings were made using a bottom-mounted autonomous underwater recorder for 30 days in September 2019, 2020, and 2021, resulting in a total recording effort of 480 hours.
Results: Our results show that broadband underwater noise levels (dBRMS) during pre-lockdown were significantly higher, particularly at frequencies below 1kHz, than during and post-lockdown. This is likely due to a decrease in the proportion of boat acoustic presence during the lockdown. Although the proportion of whale songs detected did not vary among years, whale songs were detected similarly throughout the day during the lockdown, compared to pre-and-post lockdown where the proportion of whale song presence decreased during hours when more boats were present.
Conclusions: This study shows a clear change in underwater noise levels during the COVID-19 lockdown, likely due to a decrease in boat presence. The study also highlights the potential impact of noise associated with boat traffic on humpback whale singing activity. The results of this study can inform the Conservation Areas of Osa (ACOSA) in charge of managing Caño Island Biological Reserve, to develop and implement mitigation measures to regulate underwater anthropogenic noise associated with tour boats.
Migratory destinations of endangered humpback whales, Megaptera novaeangliae (Cetartiodactyla: Balaenopteridae), from El Salvador
Authors: Ransome Nicola , Castaneda Melvin G. , Cheeseman Ted , Calambokidis John , Sharpe Fred 
Published: November 2023

Introduction: The study of many aspects of cetacean ecology is made possible by identifying individuals through space and time. Humpback whales (Megaptera novaeangliae) can be easily identified by photographing their ventral tail flukes’ unique shape and pigmentation patterns. The small and endangered distinct population segment (DPS) of Central America humpback whales visit El Salvador seasonally each winter; however, dedicated research has been extremely limited there. Before 2018, only 11 individual whales had been photo-identified, and the migratory destinations of Salvadoran humpback whales were unknown. In recent years, photo-identification efforts have increased, and today there are 92 individually identified humpback whales from El Salvador.
Objective: To identify the main high-latitude feeding areas of Salvadoran humpback whales.
Methods: Using the online matching platform Happywhale, Salvadoran whales were matched via automated image recognition to a global humpback whale fluke photo-identification catalog of 66 043 individuals.
Results: In total, 80 (87.0 %) of the whales photographed in El Salvador were matched to individuals seen in North Pacific feeding areas. Sighting histories of Salvadoran whales resighted in feeding areas ranged from two to 29 years (average = 12.1, SD = 5.8). While we note that survey effort was likely very different between regions, the main feeding area of Salvadoran humpback whales on Happywhale was Central California (n = 70, 76.1 %). Of these whales, 21 (22.8 %) had also been sighted in Southern California, while just three (3.3 %) individual whales were registered only in Southern California. Additionally, two whales (2.2 %) were sighted in Southern British Columbia, Canada, and one whale was matched to a humpback whale from Southeast Alaska. This whale (of unknown sex) has a sighting history of 27 years but no prior documentation in a breeding area and is the first published sighting of a Southeast Alaskan humpback whale in the breeding area of the endangered Central America DPS.
Conclusions: Our study shows that while Salvadoran humpback whales were matched to various feeding areas in the Eastern North Pacific, their primary migratory destinations are in Southern and Central California.
Changes of clinical and echocardiographic parameters within a year after COVID-19 pneumonia in patients without cardiovascular diseases, depending on the obesity presence
Authors: Yaroslavskaya E. I. , Shirokov N. E. , Krinochkin D. V. , Garanina V. D. , Korovina I. O. , Osokina N. A. , Migacheva A. V. , Sapozhnikova A. D. , Petelina T. I. 
Published: November 2023

Aim. To study the changes of clinical and echocardiographic parameters in people without cardiovascular diseases (CVDs) within a year after coronavirus disease 2019 (COVID-19) depending on the obesity presence.Material and methods. During the year after COVID-19 pneumonia, the clinical and echocardiographic parameters of 21 patients with obesity and without CVD were compared. The group both without CVDs and obesity consisted of 52 patients comparable by sex and age.Results. Newly developed CVDs were registered in 55% and 17% of the group with and without obesity, respectively. Left ventricular (LV) global longitudinal strain 3 months (-18,4±2,3 vs -20,6±2,2%, p=0,010) and one year after COVID-19 pneumonia (-18,8±1,8 vs -20,8±2,5%, p=0,021) was lower in the group with obesity. Lateral (e' later) (10,8±3,3 vs 13,1±2,9 cm/s (p=0,007)) and septal (e' sept) (8,5±2,7 vs 10,1±2,0 cm/s (p=0,011)) early diastolic mitral annulus velocity, as well as the ratio of early and late diastolic LV filling (E/A) (1,1±0,3 vs 1,2±0,3 (p=0,019)) at the end of the follow-up were lower in the group with obesity.Conclusion. In people without CVDs during a year after COVID-19 pneumonia, a high prevalence of newly developed CVD was noted in 55% and in 17% of people with and without obesity, which was accompanied by worse LV systolic and diastolic function in the group with obesity.