bluuebunny/crossref_metadata_2025_split huggingface dataset:
Interaction between water, crop residue and fertilization management on the source-differentiated nitrogen uptake by rice
Authors: Vitali Andrea , Russo Federica , Moretti Barbara , Romani Marco , Vidotto Francesco , Fogliatto Silvia , Celi Luisella , Said-Pullicino Daniel 
Published: January 2024

AbstractAlternate wetting and drying (AWD) is an effective water-saving practice for rice cultivation that may however promote nitrogen (N) losses compared to continuous flooding (CF). The interaction between water, crop residue and N fertilization management can influence the contribution of different N sources to plant uptake. We hypothesized that microbial processes driving the source-differentiated N supply for rice uptake during the early growth stages will depend on the interaction between water management, the timing of straw incorporation with respect to flooding and the temporal distribution of mineral N application. Rice was grown for 60 days in mesocosm experiment involving a factorial design with (i) two water regimes (CF vs. AWD) and (ii) three straw and fertilizer managements, during which soil N, porewater chemistry, plant growth and N uptake were evaluated. Source partitioning of plant N between fertilizer-, straw- and soil-derived N was achieved by means of a dual-stable isotope 15N tracing approach. Although AWD reduced total N uptake by about 4–25% with respect to CF, this could only be partly attributed to a lower uptake of fertilizer-N (and lower fertilizer-N use efficiency), suggesting that other N sources were affected by water management. Our findings evidence how the interaction between soil redox conditions and the availability of labile C and inorganic N strongly determined the supply of soil-derived N through microbial feedback and priming responses. Although incorporated straw contributed only minimally to rice N, it represented the primary driver controlling plant N nutrition through these microbial responses. These insights may contribute to identify suitable fertilization practices that favour plant N uptake during the early stages of rice growth under AWD.
Pediatric sellar teratoma – Case report and review of the literature
Authors: Kürner Katja , Greuter Ladina , Roethlisberger Michel , Brand Yves , Frank Stephan , Guzman Raphael , Soleman Jehuda 
Published: January 2024

Abstract
Background
Intracranial teratoma represents a rare neoplasm, occurring predominantly during childhood. Characteristic symptoms depend on the location but are mainly hydrocephalus, visual disturbances, hypopituitarism, and diabetes insipidus. Initial diagnosis can be challenging due to similar radiological features in both teratomas and other lesions such as craniopharyngiomas. Gross total resection is recommended if feasible and associated with a good prognosis.

Case description
A 10-year-old girl presented with newly diagnosed growth retardation, fatigue, cephalgia and bilateral hemianopia. Further laboratory analysis confirmed central hypothyroidism and hypercortisolism. Cranial magnetic resonance imaging showed a cystic space-occupying lesion in the sellar and suprasellar compartment with compression of the optic chiasm without hydrocephalus present, suspicious of craniopharyngioma. Subsequently, an endonasal endoscopic transsphenoidal near-total tumor resection with decompression of the optic chiasm was performed. During postoperative recovery the patient developed transient diabetes insipidus, the bilateral hemianopia remained unchanged. The patient could be discharged in a stable condition, while hormone replacement for multiple pituitary hormone deficiency was required. Surprisingly, histopathology revealed conspicuous areas of skin with formation of hairs and squamous epithelia, compatible with a mature teratoma.

Conclusions
We present an extremely rare case of pediatric sellar teratoma originating from the pituitary gland and a review of literature focusing on the variation in presentation and treatment. Sellar teratomas are often mistaken for craniopharyngioma due to their similar radiographic appearances. However, the primary goal of treatment for both pathologies is to decompress eloquent surrounding structures such as the optic tract, and if applicable, resolution of hydrocephalus while avoiding damage to the pituitary stalk and especially the hypothalamic structures. If feasible, the aim of surgery should be gross total resection.
Neurophysiological brain function predicts response to cognitive rehabilitation and mindfulness in multiple sclerosis: a randomized trial
Authors: Nauta Ilse M. , Kessels Roy P. C. , Bertens Dirk , Stam Cornelis J. , Strijbis Eva E. M. , Hillebrand Arjan , Fasotti Luciano , Uitdehaag Bernard M. J. , Hulst Hanneke E. , Speckens Anne E. M. , Schoonheim Menno M. , de Jong Brigit A. 
Published: January 2024

Abstract
Background
Cognitive treatment response varies highly in people with multiple sclerosis (PwMS). Identification of mechanisms is essential for predicting response.

Objectives
This study aimed to investigate whether brain network function predicts response to cognitive rehabilitation therapy (CRT) and mindfulness-based cognitive therapy (MBCT).

Methods
PwMS with cognitive complaints completed CRT, MBCT, or enhanced treatment as usual (ETAU) and performed three measurements (baseline, post-treatment, 6-month follow-up). Baseline magnetoencephalography (MEG) measures were used to predict treatment effects on cognitive complaints, personalized cognitive goals, and information processing speed (IPS) using mixed models (secondary analysis REMIND-MS study).

Results
We included 105 PwMS (96 included in prediction analyses; 32 CRT, 31 MBCT, 33 ETAU), and 56 healthy controls with baseline MEG. MEG did not predict reductions in complaints. Higher connectivity predicted better goal achievement after MBCT (p = 0.010) and CRT (p = 0.018). Lower gamma power (p = 0.006) and higher connectivity (p = 0.020) predicted larger IPS benefits after MBCT. These MEG predictors indicated worse brain function compared to healthy controls (p < 0.05).

Conclusions
Brain network function predicted better cognitive goal achievement after MBCT and CRT, and IPS improvements after MBCT. PwMS with neuronal slowing and hyperconnectivity were most prone to show treatment response, making network function a promising tool for personalized treatment recommendations.

Trial registration
The REMIND-MS study was prospectively registered in the Dutch Trial registry (NL6285; https://trialsearch.who.int/Trial2.aspx?TrialID=NTR6459).
Management of groin hernias in emergency setting: differences in indications and outcomes between laparoscopic and open approach. A single-center retrospective experience
Authors: Sbacco V. , Petrucciani N. , Lauteri G. , Cossa A. , Portinari M. , Brescia A. , Garulli G. 
Published: January 2024

Abstract
Purpose
The use of minimally invasive groin hernia repair techniques in an emergency setting is still debated and its widespread is limited.
The aim of this study is to evaluate the safety and efficacy of the laparoscopic transabdominal preperitoneal (TAPP) technique in the treatment of inguinal and femoral hernias in emergency setting based on our experience, comparing indications and outcomes with the open technique.

Methods
A retrospective analysis was performed including all patients with incarcerated and/or strangulated groin hernia who underwent emergency surgery from November 2019 to September 2022.
Perioperative variables and short- and long-term outcomes were examined.
Statistical analysis was performed using chi-square test for nominal variables and Student’s t test for continuous ones. A p value < 0.05 was considered statistically significant.

Results
Sixty-six patients were included: 29 patients were treated with TAPP technique (Tapp group) and 37 with open technique plus diagnostic laparoscopy (Open group). Patients in the TAPP group were younger, had less severe clinical scenarios, and had a trend for lower Charlson Comorbidity Index, whereas ASA score and BMI were similar. The small bowel was more frequently herniated in the open group.
Bilateral hernia repair was performed in 20.69% of patients in the Tapp group versus 0% in the Open group (p = 0.004). Bowel resection was more frequent in the open group (48.65% vs 0% of the Tapp group, p < 0.001) length of surgery was comparable in the two groups. In the Tapp group, the length of hospitalization was significantly shorter (2.59 ± 2.28 days vs. 9.08 ± 14.48 days; p = 0.023).
Postoperative complications, according to Clavien-Dindo, were more severe in Open group where there were two deaths. There were no differences in the number of readmission and re-operations at 30 days and in the recurrence rate.

Conclusions
Emergency repair of inguinal and femoral hernias using TAPP is a valuable option, safe and feasible in selected patients. In this series, indications for TAPP were reserved to younger patients with less comorbidities and less severe clinical scenario. Future randomized studies are needed to compare TAPP with open emergency hernia surgery in all settings. Potential advantages of TAPP are the reduction of postoperative complications, earlier recovery, and the possibility of bilateral treatment.
Histopronostic factors in superficial colorectal adenocarcinomas treated by endoscopy: reproducibility and impact of immunohistochemistry and digital pathology
Authors: Pontarollo Guillaume , Bonjour Maxime , Walter Thomas , Pioche Mathieu , Lavrut Pierre-Marie , Rabeyrin Maud , Hervieu Valérie , Fenouil Tanguy 
Published: January 2024

AbstractEndoscopic dissection is the first-choice treatment for superficial pT1 colorectal adenocarcinoma (sCRC). Complementary surgery decision is influenced by histopronostic factors. Prognostic significance and reproducibility of each factor are not well established. The role of immunohistochemistry (IHC) and digital pathology in this context is unknown. Our aims were (1) to evaluate each histopronostic factor reproducibility comparing HES and IHC ± digital pathology and (2) to evaluate how the different techniques would affect indications for additional surgery. We performed a single-centre retrospective study of 98 patients treated between 2010 and 2019 in Hospices Civils de Lyon, France. We analyzed physical or digital slides of HES and keratin/desmin immunostaining of 98 sCRC dissection specimens. Three pathologists evaluate the histopronostic factors including submucosal invasion depth (SMI) measured using different recommended methods. Assessment of SMI with Ueno or JSCCR methods showed good to excellent interobserver reproducibility (IOR) (ICCs of 0.858 to 0.925) using HES staining and IHC. Assessment of budding on HES sections was poorly reproducible compared to IHC which exhibit moderate IOR (κ = 0.714). IHC increased high-grade budding detection. For lymphovascular invasion and poor differentiation, the IOR was poor (κ = 0.141, 0.196 and 0.313 respectively). IHC gave a better reproducibility for further treatment indication according to JSCCR criteria (κ = 0.763) or forthcoming European guidelines (κ = 0.659). Digital pathology was equivalent to the microscope for all analyses. Histopronostic factor reproducibility in sCRC is moderate. Immunohistochemistry may facilitate the evaluation of certain criteria and improve the reproducibility of treatment decisions.
Application of the Global Uncertainty and Sensitivity Analysis to assess the importance of deadwood characteristics for forest biodiversity
Authors: Mazziotta Adriano , Kangas Annika , De Pellegrin Llorente Irene , Tikkanen Olli-Pekka , Eyvindson Kyle 
Published: January 2024

AbstractData acquisition for sustainable forest management has focused on obtaining high quality information to estimate biomass. Improving the quality of non-timber sustainability indicators, like deadwood volume, has been a minor interest. To explore how inventory approaches could be improved, we applied a Global Uncertainty and Sensitivity Analysis (GUSA) to evaluate which factors propagate more errors in deadwood modelling and how better data collection can minimize them. The impact of uncertainty on deadwood characteristics (diameter, collapse ratio, decay class, tree species, and position) was explored under stakeholders´ preferences, management actions, and climate change scenarios. GUSA showed that removing the prediction error in deadwood tree species and diameter would alter the most the total uncertainty in deadwood volume. We found that assessment of high deadwood volume was less uncertain for the scenarios where small deadwood items were left decaying on the forest floor (BAU) and for high-end climate change scenario (RCP8.5) which resulted in lower deadwood accumulation in forest stands and therefore also in lower likelihood of erroneous estimates. Reduced uncertainty in tree species and diameter class will elevate the certainty of deadwood volume to a similar level achieved in living biomass estimation. Our uncertainty and sensitivity analysis was successful in ranking factors propagating errors in estimate of deadwood and identified a strategy to minimize uncertainty in predicting deadwood characteristics. The estimation of uncertainty in deadwood levels under the scenarios developed in our study can help decision makers to evaluate risk of decreasing deadwood value for biodiversity conservation and climate change mitigation.
From Diverse Perspectives to Unified Strategies: European University Alliances and the Development of Adaptable Science Communication Concepts
Authors: Herrmann Vanessa J. , Heimer Annabell , Eichentopf Inga-Maria , Süß Gunter 
Published: January 2024

AbstractCommunicating scientific subjects to non-academic, non-specialist, or very young audiences using various event formats (lecture series, panel discussions, science slams, Children’s Universities, Citizen Universities, etc.) is a key aspect of science communication. In the EURECA-PRO University Alliance, the implementation of these kinds of formats will be given greater focus at all institutions to make significant topics accessible in ways that go beyond the institutional walls of the universities.To this end, approaches are being developed and tested to identify and reduce existing hurdles for the public. At the same time, in an international structure such as EURECA-PRO, it is essential to know individual frameworks to ensure that measures promoting a uniform strategy can be implemented by everyone.In order to develop adaptable strategies for universities with different thematic focuses and locations in Europe, certain conditions for success must be identified and considered. In addition to the needs and resources of target groups, the requirements, and opportunities of the universities—as dictated by their respective circumstances—must also be considered. Using the examples of the EURECA-PRO partners Technical University of Crete in Chania (TUC), Silesian University of Technology in Gliwice (SUT), and Montanuniversität Leoben (MUL), challenges and results will be discussed.
Prähospitale Diagnostik und Therapie des akuten Schlaganfalls
Authors: Berberich Anne , Podasca Claudia , Urbanek Christian , Nagel Simon , Purrucker Jan 
Published: January 2024

ZusammenfassungSchlaganfälle gehören zu den häufigsten Erkrankungen in Deutschland und machen einen großen Anteil der Rettungsdiensteinsätze aus. Aufgrund der hochgradig zeitkritischen Erkrankung sind eine zeiteffektive prähospitale Erkennung des Schlaganfalls, die Therapie akuter ABC-Probleme (ABC „airway, breathing, circulation“/Atemweg, Atmung, Kreislauf) und die schnelle Klinikzuweisung sehr wichtig. Eine kausale Therapie wird prähospital nicht begonnen. Durch die Einführung der endovaskulären Therapie, die nach neuester Studienlage für geeignete Patienten in einem Zeitfenster bis zu 24 h infrage kommt, ist die Klinikzuweisung komplexer geworden. Zur präzisen Zuteilung der Patienten sind eine genaue Voranmeldung, die idealerweise die Abschätzung der Schlaganfallschwere beinhaltet, und eine gute Koordination von Leitstelle, Rettungspersonal und Klinikärzten notwendig. Zukünftige Optimierungsmöglichkeiten der prähospitalen Schlaganfallversorgung bestehen in der Etablierung klarer Zuweisungskonzepte und neurologischer Telenotärzte.
Analysis of alkali-activated mineral wool-slag binders: evaluating the differences between one-part and two-part variations
Authors: Adesanya Elijah , Dabbebi Rawia , Rößler Christine , Pavlin Majda , Li Zhenming , Luukkonen Tero , Yliniemi Juho , Illikainen Mirja 
Published: January 2024

AbstractTwo synthesis pathways (one- and two-part) in alkali-activated binders were compared using ground granulated blast furnace slag (GGBFS), mineral wool (MW) activated using dry and liquid alkali activators with similar Na2O/SiO2 modulus. The effect of activator type on reaction kinetics, strength development, setting times, and durability shows that one-part synthesis does not only improve early strength, but also provide better durability properties. While the highest compressive strength (56 MPa, 90 days) was achieved for the one-part mix (DM), the reaction products (presence of Mg–Al layered double hydroxide and C–S–H-like phases) observed for both mortar mixes were similar. The DM mortars showed better resistance to sulfate attack than two-part mix (WM) mortars and sets faster. The results highlight the significance of the one-part pathways in the synthesis of alkali-activated materials.
Mixed Averaging Procedures
Authors: Errante Michele , Klein Markus , Ferrero Andrea , Larocca Francesco , Scovazzi Guglielmo , Germano Massimo 
Published: January 2024

AbstractThestatisticaloperators typically applied in postprocessing numerical databases for statistically steady turbulence are a mixture of physical averages in homogeneous spatial directions and in time. Alternative averaging operators may involve phase or ensemble averages over different simulations of the same flow. In this paper, we propose straightforward metrics to assess the relative importance of these averages, employing a mixed averaging analysis of the variance. We apply our novel indicators to two statistically steady turbulent flows that are homogeneous in the spanwise direction. In addition, this study highlights the local effectiveness of the averaging operator, which can vary significantly depending on the mean flow velocity and turbulent length scales. The work can be utilized to identify the most effective averaging procedure in flow configurations featuring at least two homogeneous directions. Thus, this will contribute to achieving better statistics for turbulent flow predictions or reducing computing time.
Effect of metformin and lifestyle intervention on adipokines and hormones in breast cancer survivors: a pooled analysis from two randomized controlled trials
Authors: Johansson Harriet , Bellerba Federica , Macis Debora , Bertelsen Bjørn-Erik , Guerrieri-Gonzaga Aliana , Aristarco Valentina , Viste Kristin , Mellgren Gunnar , Di Cola Giulia , Costantino Jemos , Scalbert Augustin , Sears Dorothy D. , Gandini Sara , DeCensi Andrea , Bonanni Bernardo 
Published: January 2024

Abstract
Purpose
We investigated the effect of metformin and lifestyle intervention on metabolic, inflammatory, and steroid biomarkers of breast cancer (BC) recurrence risk in two intervention trials among BC survivors with overweight or obesity.

Methods
Baseline and follow-up serum samples collected during the two trials were analyzed and data pooled. The USA trial (Reach for Health) included postmenopausal BC survivors (n = 333) randomly assigned to 6-month metformin vs placebo and lifestyle intervention (LSI) vs control (2 × 2 factorial design). The Italian trial (MetBreCS) included BC survivors (n = 40) randomized to 12-month metformin vs placebo. Insulin resistance (HOMA-IR), adipokines, cytokines, and steroids were measured.

Results
Metformin compared to placebo showed a favorable decrease in leptin (− 8.8 vs − 3.5 ng/mL; p < 0.01) and HOMA-IR (− 0.48 vs − 0.25; p = 0.03), and an increase in SHBG (2.80 vs 1.45 nmol/L; p < 0.01). Excluding women taking aromatase inhibitors, metformin (n = 84) compared to placebo (n = 99) decreased estradiol (− 4 vs 0 pmol/L; p < 0.01), estrone (− 8 vs 2 pmol/L; p < 0.01) and testosterone (− 0.1 vs 0 nmol/L-; p = 0.02). LSI favorably affected adiponectin (0.45 vs − 0.06 ug/mL; p < 0.01), leptin (− 10.5 vs − 4.4 ng/mL; p < 0.01), HOMA-IR (− 0.6 vs 0.2; p = 0.03), and SHBG (2.7 vs 1.1 nMol/L; p = 0.04) compared to controls. The strongest impact was observed combining metformin with LSI on adipokines, CRP, SHBG, and estrogens.

Conclusions
Supportive healthy lifestyle programs combined with metformin to achieve maximal risk reduction among BC cancer survivors are recommended, especially for those with obesity in menopause.
Fructobacillus fructosus OS-1010 strain stimulates intestinal cells to secrete exosomes that activate muscle cells
Authors: Kashiwagi Riku , Udono Miyako , Katakura Yoshinori 
Published: January 2024

AbstractFructobacillus is a lactic-acid bacterium recently identified in fructose-rich environments. Fructobacillus is also known to exhibit unusual growth characteristics due to an incomplete gene encoding alcohol/acetaldehyde hydrogenase, which results in an imbalance in the nicotinamide adenine mononucleotide (NAD+)/NADN levels. Recently, the addition of d-fructose to the culture medium of Fructobacillus strains increased the intracellular nicotinamide mononucleotide (NMN) content. In the present study, we evaluated the functionality of Fructobacillus that produces high levels of NMN, using one substrain (Fructobacillus fructosus OS-1010). Therefore, in this study, we examined its functionality in the interaction between intestinal cells and muscle cells. The results showed that supernatant derived from intestinal epithelial cells (Caco-2 cells) treated with F. fructosus OS-1010 activated muscle cells (C2C12 cells). Further analysis revealed that Caco-2 cells treated with F. fructosus OS-1010 secreted exosomes known as extracellular vesicles, which activated the muscle cells. Furthermore, pathway analysis of the target genes of miRNA in exosomes revealed that pathways involved in muscle cell activation, including insulin signaling and cardiac muscle regulation, neurotrophic factors, longevity, and anti-aging, can be activated by exosomes. In other words, F. fructosus OS-1010 could activate various cells such as the skin and muscle cells, by secreting functional exosomes from the intestinal tract.