bluuebunny/crossref_metadata_2025_split huggingface dataset:
Postorgasmic illness syndrome: one or several entities? A retrospective cohort study
Authors: Chea Maryane , Teng Maëlys , Chesnel Camille , Lagnau Philippe , Amarenco Gérard , Hentzen Claire 
Published: October 2023

Abstract

Background
Postorgasmic illness syndrome (POIS) is a rare syndrome in which patients experience various physical and cognitive symptoms after ejaculation, and its pathophysiology remains unknown.

Aim
The aim of this study was to characterize the clinical presentations, disease course, and treatment outcomes in outpatients, as well as to examine the validity of the preliminary criteria and symptom clusters of POIS.

Methods
This retrospective monocentric study was conducted in a neurourology department, with patients included from 2010 to 2023. The diagnostic criteria and symptom cluster descriptions were based on previous studies.

Outcomes
The study focused on the clinical features of POIS, the complementary tests performed, the treatments tried, and their effectiveness.

Results
Thirty-seven men were included in the study, with symptom onset occurring at a mean ± SD age of 23.6 ± 7.4 years. The mean time from ejaculation to symptom onset was 1 hour 22 minutes ± 3 hours 42 minutes. The mean duration of symptoms was 4.7 ± 3.4 days. Seventeen patients (46%) developed the symptoms primarily, whereas in 20 (54%) they appeared secondarily. All preliminary criteria were met in 19 patients (51%). The most common symptom clusters were “general” in all 37 patients (100%; eg, asthenia and concentration difficulties) and “head” in 35 patients (95%; mostly headache and a foggy feeling). In terms of treatments, antihistamines and nonsteroidal anti-inflammatory drugs were tried and partially improved symptoms for some patients.

Clinical Implications
This study helps to further characterize POIS by specifying the most frequent symptoms and comparing them with the initial criteria.

Strengths and Limitations
To our knowledge, this is one of the largest cohorts of patients consulting for symptoms suggestive of POIS. There are limitations due to the retrospective nature of the data collection, such as missing data and imprecision of treatment efficacy.

Conclusion
The majority of participants met at least 3 of the preliminary diagnostic criteria, with a majority of symptoms in the general and head clusters. However, the determination of predictive factors for treatment response based on the typology of the disorders remains to be established.
Neutrino signatures of 100 2D Axisymmetric Core-Collapse Supernova Simulations
Authors: Vartanyan David , Burrows Adam 
Published: October 2023

ABSTRACT
We present in this paper a public data release of an unprecedentedly large set of core-collapse supernova (CCSN) neutrino emission models, comprising 100 detailed 2D axisymmetric radiation-hydrodynamic simulations evolved out to as late as ∼5 s post-bounce and spanning an extensive range of massive-star progenitors. The motivation for this paper is to provide a physically and numerically uniform benchmark data set to the broader neutrino detection community to help it characterize and optimize subsurface facilities for what is likely to be a once-in-a-lifetime galactic supernova burst event. With this release, we hope to (1) help the international experiment and modelling communities more efficiently optimize the retrieval of physical information about the next galactic CCSN, (2) facilitate the better understanding of core-collapse theory and modelling among interested experimentalists, and (3) help further integrate the broader supernova neutrino community.
Impact of orbiting satellites on star formation rate evolution and metallicity variations in Milky Way-like discs
Authors: Annem Bhargav , Khoperskov Sergey 
Published: October 2023

ABSTRACT
At least one major merger is currently taking place in the Milky Way (MW). The Sagittarius (Sgr) dwarf galaxy is being tidally destroyed while orbiting around the MW, whose close passages perturb the disc externally. In this work, using hydrodynamical simulations, we investigate how massive dwarf galaxies on quasi-polar Sgr-like orbits impact the star formation (SF) inside the MW-like discs. First, we confirm that interactions with orbiting satellites enhance the SF rate in the host. However, prominent SF bursts are detected during the very close passages (&lt;20 kpc) of massive (2 × 1010 M⊙) gas-poor satellites. For gas-rich satellites, while we observe substantial enhancement of the SF, we do not detect prominent peaks in the SF history of the host. This can be explained by the steady gas accretion from the satellite smoothening short-term variations in the SF. The impact of the satellite perturbations, especially its first encounters, is seen mainly in the outer (&gt;10 kpc) disc. We also found that the close passages of satellites cause the formation of low-metallicity stars in the host, and the effect is the most prominent for gas infall from the satellites resulting in the dilution of the mean stellar metallicity. Our simulations are in favour of causality between the recent passages of the Sgr and the bursts of the SF in the solar neighbourhood (≈1 and ≈2 Gyr ago); however, to reproduce the SF burst at its first infall (≈6 Gyr), we require a very close passage (&lt;20 kpc) with subsequent substantial mass-loss of the Sgr precursor.
Metric f(R) gravity with dynamical dark energy as a scenario for the Hubble tension
Authors: Montani Giovanni , De Angelis Mariaveronica , Bombacigno Flavio , Carlevaro Nakia 
Published: October 2023

ABSTRACT
We introduce a theoretical framework to interpret the Hubble tension, based on the combination of a metric f(R) gravity with a dynamical dark energy contribution. The modified gravity provides the non-minimally coupled scalar field responsible for the proper scaling of the Hubble constant, in order to accommodate for the local SNIa pantheon+ data and Planck measurements. The dynamical dark energy source, which exhibits a phantom divide line separating the low redshift quintessence regime (−1 &lt; w &lt; −1/3) from the phantom contribution (w &lt; −1) in the early Universe, guarantees the absence of tachyonic instabilities at low redshift. The resulting H0(z) profile rapidly approaches the Planck value, with a plateau behaviour for z ≳ 5. In this scenario, the Hubble tension emerges as a low redshift effect, which can be in principle tested by comparing SNIa predictions with far sources, like QUASARS and gamma ray bursts.
Map-based cosmology inference with weak lensing – information content and its dependence on the parameter space
Authors: Boruah Supranta S , Rozo Eduardo 
Published: October 2023

ABSTRACT
Field-level inference is emerging as a promising technique for optimally extracting information from cosmological data sets. Previous analyses have shown field-based inference produces tighter parameter constraints than power spectrum analyses. However, estimates of the detailed quantitative gain in constraining power differ. Here, we demonstrate the gain in constraining power depends on the parameter space being constrained. As a specific example, we find that lognormal field-based analysis of an LSST Y1-like mock data set only marginally improves constraints relative to a 2-point function analysis in Lambda cold dark matter (ΛCDM), yet it more than doubles the constraining power of the data in the context of wCDM models. This effect reconciles some, but not all, of the discrepant results found in the literature. Our results suggest the importance of using a full systematics model when quantifying the information gain for realistic field-level analyses of future data sets.
CARD9 deficiency with allergic bronchopulmonary aspergillosis (ABPA)-like presentation: a case report
Authors: Fallahi Mazdak , Mahdaviani Seyed Alireza , Shafiei Mohammadreza , Ghadimi Soodeh , Rezaei Nima , Klein Christoph , Strobel Sophie , Jamee Mahnaz 
Published: October 2023

Abstract
Purpose: We present a patient with CARD9 deficiency and allergic bronchopulmonary aspergillosis (ABPA)-like presentation. Methods: Following medical history taking and routine laboratory investigations, an inborn error of immunity was suspected, and the responsible variant was identified using Whole Exome Sequencing and confirmed by Sanger sequencing. Results: A 14-year-old Iranian female presented with a history of chest pain, productive cough, dyspnea, malaise, and recurrent fever. Imaging by computed tomography (CT scan), chest X-ray (CXR), bronchoscopy, transbronchial lung biopsy (TBLB), and histopathology findings led to a diagnosis of ABPA-like presentation. The genetic study showed an autosomal recessive homozygous mutation in the CARD9 gene. Clinical remission was achieved following the administration of voriconazole, which was continued as prophylaxis. Conclusions: This is the first-time report of a patient with inherited CARD9 deficiency and ABPA-like presentation due to Aspergillus Terrus. This study paves the way to elucidate immunological mechanisms underlying CARD9 deficiency and aspergillosis.
Inadvertent inoculation of Apophysomyces following tetanus immunisation- a case report
Authors: Darlington Christopher , Cunningham Sophie , Asomah Francis , Norton Robert 
Published: October 2023

Abstract
Mucormycosis is a rare, life-threatening fungal infection. While typically affecting immunosuppressed individuals, cases in the immunocompetent have been reported, particularly secondary to trauma, and the subspecies Apophysomyces. These fungi are typically difficult to isolate. This case report describes cutaneous Mucormycosis caused by Apophysomyces complex at a vaccination site, given following a motor vehicle accident. This life-threatening infection occurred in an immunocompetent 17-year old girl, resulting in multiple hospital admissions and finally, radical surgical debridement of her left upper limb. This case highlights the aggressive nature of this infection and the importance of early clinical recognition as effective treatment requires aggressive debridement typically prior to microbiological confirmation.
Bilateral serous retinal detachment in pre-eclampsia a rare but favorable complication: case report
Authors: Benlghazi Abdelhamid , Bouhtouri Yassine , Belouad Moad , Brarou Houda , Messaoudi Hamza , Benali Saad , El Hassani Moulay Mehdi , Kouach Jaouad 
Published: October 2023

Abstract
Pre-eclampsia is a serious pregnancy-related condition that can cause damage to multiple organs, including the eyes. While pre-eclampsia is commonly associated with the narrowing of the retinal arteries, more severe complications such as cortical blindness, optic neuropathy, and serous retinal detachment (SRD) can occur in rare cases. This case report describes a 26-year-old primiparous woman who presented with headaches, bilateral visual fog, and tinnitus and was diagnosed with pre-eclampsia based on elevated blood pressure and proteinuria. Despite receiving antihypertensive treatment, the patient’s visual symptoms worsened, prompting an emergency cesarean section. An ophthalmological examination revealed bilateral macular SRD. SRD in pre-eclampsia is a rare complication that can occur even in the immediate post-partum period, with a favorable prognosis. It should be noted that any pre-eclamptic patient presenting with visual symptoms in the third trimester or post-partum should be considered for serous retinal detachment.
Peer review’s irremediable flaws: Scientists’ perspectives on grant evaluation in Germany
Authors: Barlösius Eva , Paruschke Laura , Philipps Axel 
Published: October 2023

Abstract
Peer review has developed over time to become the established procedure for assessing and assuring the scientific quality of research. Nevertheless, the procedure has also been variously criticized as conservative, biased, and unfair, among other things. Do scientists regard all these flaws as equally problematic? Do they have the same opinions on which problems are so serious that other selection procedures ought to be considered? The answers to these questions hints at what should be modified in peer review processes as a priority objective. The authors of this paper use survey data to examine how members of the scientific community weight different shortcomings of peer review processes. Which of those processes’ problems do they consider less relevant? Which problems, on the other hand, do they judge to be beyond remedy? Our investigation shows that certain defects of peer review processes are indeed deemed irreparable: (1) legitimate quandaries in the process of fine-tuning the choice between equally eligible research proposals and in the selection of daring ideas; and (2) illegitimate problems due to networks. Science-policy measures to improve peer review processes should therefore clarify the distinction between field-specific remediable and irremediable flaws than is currently the case.
Legal–institutional design and dynamic capabilities for mission-oriented innovation agencies: a new framework
Authors: Spanó Eduardo , Monnerat Rafael , Pacheco Carlos Américo , Bonacelli Maria Beatriz Machado 
Published: October 2023

Abstract
Recent scholarship emphasizes the need for mission-oriented innovation policies (MOIPs) to tackle grand challenges and the importance of dynamic capabilities in innovation agencies for their implementation. However, the development of dynamic capabilities in innovation agencies, especially in relation to the legal and institutional design of such agencies, remains understudied. We propose a framework integrating research on innovation policy, dynamic capabilities, and legal institutionalism, adapting the three high-order dynamic capabilities—sense, seize, and transform—into nine more concrete low-order capabilities for implementation of MOIPs. We also look at rules and institutional design related to five groups of routines affecting the development of dynamic capabilities: (1) governance, (2) organizational design, (3) budget and finance, (4) public procurement and partnerships, and (5) human resources. We conclude by outlining the analytical and policy implications for (re)designing innovation agencies to implement MOIPs.
Integration of simulation-based education in anaesthesiology specialist training
Authors: Savoldelli Georges L. , Burlacu Crina L. , Lazarovici Marc , Matos Francisco Maio , Østergaard Doris 
Published: October 2023

BACKGROUNDDespite its importance in education and patient safety, simulation-based education and training (SBET) is only partially or poorly implemented in many countries, including most European countries. The provision of a roadmap may contribute to the development of SBET for the training of anaesthesiologists.OBJECTIVETo develop a global agenda for the integration of simulation into anaesthesiology specialist training; identify the learning domains and objectives that are best achieved through SBET; and to provide examples of simulation modalities and evaluation methods for these learning objectives.DESIGNUtstein-style meeting where an expert consensus was reached after a series of short plenary presentations followed by small group workshops, underpinned by Kern's six-step theoretical approach to curriculum development.SETTINGUtstein-style collaborative meeting.PARTICIPANTSTwenty-five participants from 22 countries, including 23 international experts in simulation and two anaesthesia trainees.RESULTSWe identified the following ten domains of expertise for which SBET should be used to achieve the desired training outcomes: boot camp/initial training, airway management, regional anaesthesia, point of care ultrasound, obstetrics anaesthesia, paediatric anaesthesia, trauma, intensive care, critical events in our specialty, and professionalism and difficult conversations. For each domain, we developed a course template that defines the learning objectives, instructional strategies (including simulation modalities and simulator types), and assessment methods. Aspects related to the practical implementation, barriers and facilitators of this program were also identified and discussed.CONCLUSIONSWe successfully developed a comprehensive agenda to facilitate the integration of SBET into anaesthesiology specialist training. The combination of the six-step approach with the Utstein-style process proved to be extremely valuable in supporting content validity and representativeness. These results may facilitate the implementation and use of SBET in several countries.TRIAL REGISTRATIONNot applicable.
RETRACTION OF CYSTOID MACULAR EDEMA FROM THE FOVEA AFTER INTRAVITREAL ANTI-VASCULAR ENDOTHELIAL GROWTH FACTOR THERAPY FOR BIRDSHOT CHORIORETINOPATHY
Authors: Ba-Ali Shakoor , Fuchs Josefine , Larsen Michael 
Published: October 2023

Purpose:
To report the effect of anti-vascular endothelial growth factor inhibitor on fovea-involving cystoid macular edema in a patient with Birdshot chorioretinopathy.

Methods:
A 42-year-old male patient presented to our hospital with bilateral posterior uveitis with retinal vasculitis, cystoid macular edema, and optic disk edema. He was diagnosed with birdshot chorioretinopathy based on clinical appearance and tissue type HLA-A29.

Results:
The patient underwent vitrectomy in the right eye without any change in visual acuity. Retinal leakage was reduced by oral prednisolone, which could not be tapered below 50 mg per day without relapse. Oral prednisolone, topical dexamethasone, and subtenon Kenalog were associated with intraocular pressure rise in both eyes. Hence, his uveitis responded to steroids, but there was no detectable effect of any steroid-sparing immunomodulatory drugs. The patient had been on oral prednisolone 50 mg for five years when it was decided to attempt intravitreal vascular endothelial growth factor inhibitor injection therapy. The anti-vascular endothelial growth factor therapy diminished cystoid macular edema in the fovea and improved the visual acuity.

Conclusion:
Here, we report for the first time the long-term outcomes of anti-vascular endothelial growth factor injections on fovea-involving cystoid macular edema in Birdshot chorioretinopathy to keep steroid at the minimal possible doses and preserve a satisfying visual acuity level.
A Case of Neuroleptic Malignant Syndrome in the Context of Lithium Toxicity and Aripiprazole Use
Authors: Schultz Autumn R. , Singh Sarina , Linek-Rajapaksha Carolyn E. , Goode Heather R. , Fusick Adam J. 
Published: October 2023

Objective
Neuroleptic malignant syndrome (NMS) is a rare life-threatening condition that providers should be cognizant of when prescribing dopamine-receptor antagonists. Atypical antipsychotic agents were initially considered to have a lower risk of inducing the development of NMS compared with conventional antipsychotic. Considerable evidence, however, has suggested that atypical antipsychotics are associated with NMS, including the partial dopamine agonist, aripiprazole. There is growing evidence that other psychotropics, including lithium, cause this condition. Here, the authors present a case of a patient who developed NMS from lithium and aripiprazole and provide a literature review of reported NMS cases with either psychotropic.

Method and Results
The authors report the case of 60-year-old male patient who developed NMS over a hospital course during which both aripiprazole and lithium were prescribed. In addition, a literature review was performed and a summary of cases of NMS induced by either lithium and/or aripiprazole is provided.

Conclusions
This case adds to the growing body of literature of aripiprazole and lithium-induced NMS. Only 2 other cases are reported where concomitant aripiprazole and lithium use lead to NMS. Interestingly, our patient did develop lithium toxicity during hospitalization, but the NMS diagnosis occurred after lithium toxicity resolved. This varies from the other 2 cases where NMS developed despite lithium levels always being therapeutic. Unfortunately, there are more questions than answers surrounding this rare complication involving these 2 psychotropics and clinical vigilance is warranted when using these psychotropics especially in cases where aripiprazole and lithium are used in combination.
Ultrasensitive and multiplexed protein imaging with clickable and cleavable fluorophores
Authors: Pham Thai , Chen Yi , Labaer Joshua , Guo Jia 
Published: October 2023

AbstractSingle-cell spatial proteomic analysis holds great promise to advance our understanding of the composition, organization, interaction and function of the various cell types in complex biological systems. However, the current multiplexed protein imaging technologies suffer from low detection sensitivity, limited multiplexing capacity or technically demanding. To tackle these issues, here we report the development of a highly sensitive and multiplexed in situ protein profiling method using off-the-shelf antibodies. In this approach, the protein targets are stained with horseradish peroxidase (HRP) conjugated antibodies and cleavable fluorophores via click chemistry. Through reiterative cycles of target staining, fluorescence imaging, and fluoropohore cleavage, many proteins can be profiled in single cells in situ. Applying this approach, we successfully quantified 28 different proteins in a human formalin-fixed paraffin-embedded (FFPE) tonsil tissue, which represents the highest multiplexing capacity among the tyramide signal amplification (TSA) methods. Based on their unique protein expression patterns and their microenvironment, ∼820,000 cells in the tissue are classified into distinct cell clusters. We also explored the cell-cell interactions between these varied cell clusters and observed different subregions of the tissue are composed of cells from specific clusters.
Your body, my experience: A systematic review of embodiment illusions as a function of and method to improve body image disturbance
Authors: Portingale Jade , Krug Isabel , Liu Hermione , Kiropoulos Litza , Butler David 
Published: October 2023

AbstractEmbodiment illusions—which manipulate multisensory integration processes underlying self-perception—are increasingly used to understand and improve body image disturbance (BID): a core symptom of eating disorders (EDs) and body dysmorphic disorder (BDD). The current systematic review is the first to evaluate clinical and community-based evidence on whether (i) variations involving BID impact embodiment illusion susceptibility and (ii) embodiment illusions can improve BID. Thirty-two studies met inclusion criteria. Greater embodiment was generally observed among individuals with high (relative to low/no) BID (9 out of 14 studies; 64.29%). Embodiment produced an improvement in BID in most studies (20 out of 24; 83.33%). Effect sizes were generally medium to large across both findings. Although several issues exist within the literature (e.g., substantial methodological heterogeneity, non-validated measures), findings reiterate that disturbances in multisensory integration appear to underpin BID, although embodiment illusions offer opportunities to develop new therapeutic interventions for BID. Multiple factors are of particular interest for ensuring that embodiment illusion paradigms are best designed for future research and application (e.g., virtual reality versus real-world methods).