bluuebunny/crossref_metadata_2025_split huggingface dataset:
Ni‐Co‐based bimetal organic framework as superior electrode material for hydrogen evolution reaction and supercapacitors
Authors: Bhardwaj Shiva , Srivastava Rishabh , Mageto Teddy , Reddy Sudhakar , Dawsey Tim , Kumar Anuj , Gupta Ram 
Published: December 2023

AbstractMetal‐organic frameworks (MOFs) possess several desirable properties, including a homogeneous crystal structure, variable porosity, high surface area, and a notable adsorption affinity, making them highly promising contenders for deployment as electrode materials in supercapacitors (SCs) and water electrolyzers, which are acknowledged for the ever‐increasing demand for instantaneous energy. Herein, we report the rationally assembled Ni‐Co‐based bimetallic MOF compounds using a glutaric acid as an organic ligand and low‐temperature hydrothermal treatment that surmounts the electrocatalytic and electrochemical charge storage activity in an alkaline medium. The NiCo‐MOF surpassed the hydrogen evolution reaction (HER) among other as‐synthesized materials, exhibiting the least overpotential of 182 mV at 10 mA/cm2 of current density, showed splendid kinetics with a turnover frequency of 2.86 s−1, and higher stability after 1000 HER cycles in 1 M KOH. Furthermore, NiCo‐MOF impetuses were employed for SC application and displayed the highest specific capacitance of 978 F/g than Ni‐MOF (706 F/g) and Co‐MOF (91 F/g) at 1 A/g of current density. Theoretical studies exhibited that the optimal electronic coupling and synergistic effect due to Ni‐Co sites enhances the overall electronic properties of NiCo‐MOF. Therefore, enhancing its electrochemical performance concerning water‐splitting and charge storage. This study showcases a novel approach for producing ultrathin and flexible bimetallic MOF‐based electrode material to enrich the performance in electrocatalytic HER and SCs.
Association of prognostic nutritional index with mortalities in American adult cancer survivors: A cohort study based on NHANES, 1999–2018
Authors: Zhao Li , Shen Xia , Yang Long , Wang Pengfei , Zhang Jianfeng , Liu Ning , Xie Yan 
Published: December 2023

AbstractThe prognostic nutritional index (PNI) has been associated with disease progression and overall survival among cancer patients. Nonetheless, the association between PNI and mortality risk in adult cancer patients within the United States remains unexplored. This study aims to elucidate the connection between PNI and prognostic outcomes in American adult cancer patients. This cohort study derived data from the National Health and Nutrition Examination database, involving 4366 American adults diagnosed with cancer between 1999 and 2018. The nutritional status was assessed using the PNI, with higher PNI scores indicating a more favorable nutritional status. The study employed Kaplan–Meier curves and Cox proportional hazard regression to investigate the impact of PNI on various outcomes, including all‐cause mortality (ACM), cardiovascular mortality (CAM), and malignancy tumor mortality (MTM) among adult cancer patients. Furthermore, restricted cubic spline models were used to examine the potential nonlinear relationship between the variables by creating hazard ratio (HR) curves at four specific points. The median follow‐up duration was 84 months, during which 1530 (35.04%) cases of ACM occurred, including 331 (13.67%) CAM and 449 (10.45%) MTM. COX regression analysis revealed a significant inverse association between PNI and patient prognosis, with HRs of 0.95 (95% CI: 0.93–0.96, p < .001) for ACM, 0.93 (95% CI: 0.90–0.96, p < .001) for CAM, and 0.94 (95% CI: 0.91–0.97, p < .001) for MTM. Both Kaplan–Meier analyses and restricted cubic spline curves showed significant differences in mortality rates related to PNI (p < .001, nonlinear p < .001). Our study provides compelling evidence of a clear association between PNI and reduced risk of ACM, CAM, and MTM in adult cancer patients in the United States. These findings underscore the significance of incorporating PNI as a possible prognostic indicator for individuals diagnosed with cancer.
Two‐phase flow behavior in CO2 geological storage considering spatial parameter heterogeneity
Authors: Zhong Yiyan , Li Qi , Xu Liang , Wen Yiping , Hou Yunlu , Gao Wenbin 
Published: December 2023

AbstractSaline aquifer rocks exhibit significant spatial randomness due to geological sedimentation processes. To address the issue of the heterogeneity of rock formations in numerical simulations, it is common practice to homogenize rock layers with similar lithologies. However, the acceptability of the errors generated during homogenized computations is a major concern and should be investigated. Therefore, to study the influence of heterogeneity at the storage site on the CO2 migration behavior, the Monte Carlo simulation–random finite element method (MCS‐RFEM) was combined with a CO2 two‐phase flow model to compare the effects of the coefficient of variation (Cv) and correlation length (λx) of random reservoir permeability fields on the migration distance and extent of CO2 storage under the same mean conditions. The results showed that higher Cv and λx values significantly reduced the CO2 migration distance while increasing the spread extent. Compared to the homogeneous model, at a λx value of 100 m, the CO2 migration distance decreased by 5.05%, while the profile sweep area increased by 6.20%. Concurrently, with increasing Cv, the area with a CO2 volume fraction higher than 0.75 decreased by 20.22%, while an increase in λx resulted in a 42.35% increase in the area with a CO2 volume fraction higher than 0.75. Therefore, reservoirs with high Cv and low λx values are more suitable for safely storing CO2. © 2023 Society of Chemical Industry and John Wiley & Sons, Ltd.
How regulatory frameworks drive differences in home‐care agencies: Results from a national multicenter cross‐sectional study in Switzerland
Authors: Möckli Nathalie , Wächter Matthias , Moffa Giusi , Simon Michael , Martins Tania , Zúñiga Franziska 
Published: December 2023

AbstractIntroductionThe sustainability and rising costs of the health‐care system are of concern. Although health‐care reforms impact various areas of care, there is only limited evidence on how regulations affect home‐care agencies and health‐care delivery.ObjectivesThe primary aim was to explore different financial and regulatory mechanisms and how they drive differences in the organizational structures, processes, and work environment of home‐care agencies.Design and methodsWe used data from a national multicenter cross‐sectional study of Swiss home care that included a random sample of 88 home‐care agencies with a total of 3223 employees. Data was collected in 2021 through agency and personnel questionnaires including geographic characteristics, financial and regulatory mechanisms, service provision, financing, work environment, resources and time allocation, and personnel recruitment. We first conducted a cluster analysis to build agency groups with similar financial and regulatory mechanisms. We then performed Fisher's exact, ANOVA, and Kruskal–Wallis tests to determine group differences in organizational structures, processes, and work environments. Finally, we performed a lasso regression to determine which variables were predictive for the groups.ResultsFour agency groups were built, differing in view of financial and regulatory mechanisms and we found differences in the range and amount of services provided, with regard to employment conditions and cost structures.DiscussionThe most prominent differences were found between agency groups with versus agency groups without a service obligation. Financial incentives must be well aligned with the goal of achieving and maintaining financially sustainable, accessible, and high‐quality home care.
Second Fundão Dam Rupture Science Meeting: Updating the science
Authors: Smith Ross E. W. , Furley Tatiana H. , de Souza Abessa Denis M. , Medeiros Laila C. C. 
Published: December 2023

Abstract
The second Fundão Dam Rupture Science Meeting was held in Ouro Preto, Minas Gerais, Brazil, on 21 and 22 September 2022. A total of 100 delegates attended the meeting, which featured high-quality oral presentations and posters over the two days and lively discussions of the science presented. The meeting resulted in nine papers being published in this special series. In the discussion, it was commented that the first meeting had been more a meeting of competitive perspectives but that the second meeting featured a more collaborative sharing of knowledge. Also, there had been substantial improvement in ways to deal with the lack of pre-event data and account for other stressors in the system, and as a result, stronger conclusions regarding the recovery rates of the system were able to be made. Importantly, there was no evidence for a feasible “time bomb” of a future catastrophic release of contaminants, but it was agreed that different scenarios continue to be researched. Integr Environ Assess Manag 2024;20:70–73. © 2023 The Authors. Integrated Environmental Assessment and Management published by Wiley Periodicals LLC on behalf of Society of Environmental Toxicology & Chemistry (SETAC).
Diagnosing and treating acute myelopathies in dogs and cats
Authors: De Frias Joao Miguel , Fenn Joe 
Published: December 2023

Background: A variety of acute spinal cord disorders (myelopathies) can occur in dogs and cats. Understanding the typical clinical presentation and examination findings of the most common acute myelopathies is the key to formulating an accurate diagnostic and treatment pathway in clinical veterinary practice.Aim of the article: This article describes the characteristic clinical features for the most common acute myelopathies in dogs and cats, as well as outlining a diagnostic approach and important treatment considerations to achieve a successful outcome.
Update on diagnosing and managing osteoarthritis in cats
Authors: Langley‐Hobbs Sorrel 
Published: December 2023

Background: It is a truth now universally acknowledged that cats suffer from osteoarthritis (OA). Osteoarthritis in cats has received a lot of attention in the past 15 years, but previously it was an infrequently recognised and poorly understood problem. As veterinarians we should be assessing cats (both old and young) for the presence of OA, and should educate owners about the treatment and management of the condition.Aim of the article: This article aims to provide a broad overview of current diagnosis and management practices for OA in cats, outlining how to confirm an OA diagnosis, the treatment options that are available and when surgery may be required.
Design, synthesis, and histone deacetylase inhibition study of novel 4‐(2‐aminoethyl) phenol derivatives
Authors: Podili Runesh , Mishra K. M. Abha , Akkewar Ashish S. , Kumar Sanjay , Rayala V. V. S. Prasanna Kumari , Kulhari Uttam , Sahu Bidya D. , P. Radhakrishnanand , Sethi Kalyan K. 
Published: December 2023

AbstractHistone deacetylases (HDACs) have been identified as promising targets for anticancer treatment. The study demonstrates virtual screening, molecular docking, and synthesis of 4‐(2‐aminoethyl) phenol derivatives as HDAC inhibitors. The virtual screening and molecular docking analysis led to the identification of 10 representative compounds, which were evaluated based on their drug‐like properties. The results demonstrated that these compounds effectively interacted with the active site pocket of HDAC 3 through π‐stacking, Zn2+ coordination, hydrogen bonding, and hydrophobic interactions with catalytic residues. Furthermore, a series of 4‐(2‐aminoethyl) phenol derivatives were synthesized, and their HDAC inhibitory activity was evaluated. Compounds 18 and 20 showed significant HDAC inhibitory activity of 64.94 ± 1.17% and 52.45 ± 1.45%, respectively, compared to the solvent control. The promising results of this study encourage further research on 4‐(2‐aminoethyl) phenol derivatives and may provide significant insight into the design of novel small molecule HDAC inhibitors to fight against target‐specific malignancies of chronic obstructive pulmonary disease and nonsmall cell lung cancer in the future.
Medical radiation exposure during gastrointestinal enteral metallic stent placement: Post hoc analysis of the REX‐GI study
Authors: Tokura Junki , Yoshio Toshiyuki , Hayashi Shiro , Yamamoto Masashi , Asai Satoshi , Yakushijin Takayuki , Ikezawa Kenji , Nagaike Koji , Takagi Tadayuki , Fujisawa Toshio , Yamada Takuya , Tsumura Hidetaka , Maetani Iruru , Hori Yasuki , Ihara Hideyuki , Matsunaga Kazuhiro , Kuwai Toshio , Ito Yukiko , Hasatani Kenkei , Komeda Yoriaki , Kurita Akira , Yamaguchi Shinjiro , Maruyama Hirotsugu , Iwashita Takuji , Takenaka Mamoru , Hosono Makoto , Nishida Tsutomu 
Published: December 2023

AbstractBackground and AimRecently, the use of various endoscopic procedures performed under X‐ray fluoroscopy guidance has increased. With the popularization of such procedures, diagnostic reference levels (DRLs) have been widely accepted as the global standard for various procedures with ionizing radiation. The Radiation Exposure from Gastrointestinal Fluoroscopic Procedures (REX‐GI) study aimed to prospectively collect actual radiation exposure (RE) data and establish DRLs in gastrointestinal endoscopy units. In this post hoc analysis of the REX‐GI study, we established DRLs for each disease site by analyzing cases of gastrointestinal enteral metallic stent placement.MethodsThe REX‐GI study was a multicenter, prospective observational study conducted to collect actual RE data during gastrointestinal enteral metallic stent placement. To establish DRL values for three disease sites, namely the esophagus, gastroduodenum, and colon, we examined fluoroscopy time (FT; min), number of X‐ray images, air kerma at the patient entrance reference point (Ka,r; mGy), and the air kerma–area product (PKA; Gy cm2) during enteral metallic stent placement.ResultsFive‐hundred and twenty‐three stenting procedures were performed. The DRL values of FT (min) and the number of X‐ray images for the esophagus/gastroduodenum/colon were 9/16/18 min and 9/15/11 min, respectively. Furthermore, the DRL values of Ka,r and PKA for each disease site were 43.3/120/124 mGy and 10.3/36.6/48.4 Gy cm2, respectively. Among the procedures, esophageal stents were significantly associated with the lowest values (P < 0.001).ConclusionThe characteristics of RE vary according to disease site among gastrointestinal enteral metallic stent placements. Thus, it is desirable to set DRL values based on the disease site.
A REML method for the evidence‐splitting model in network meta‐analysis
Authors: Piepho Hans‐Peter , Forkman Johannes , Malik Waqas Ahmed 
Published: December 2023

AbstractChecking for possible inconsistency between direct and indirect evidence is an important task in network meta‐analysis. Recently, an evidence‐splitting (ES) model has been proposed, that allows separating direct and indirect evidence in a network and hence assessing inconsistency. A salient feature of this model is that the variance for heterogeneity appears in both the mean and the variance structure. Thus, full maximum likelihood (ML) has been proposed for estimating the parameters of this model. Maximum likelihood is known to yield biased variance component estimates in linear mixed models, and this problem is expected to also affect the ES model. The purpose of the present paper, therefore, is to propose a method based on residual (or restricted) maximum likelihood (REML). Our simulation shows that this new method is quite competitive to methods based on full ML in terms of bias and mean squared error. In addition, some limitations of the ES model are discussed. While this model splits direct and indirect evidence, it is not a plausible model for the cause of inconsistency.
Oxygen Delivery Biomaterials in Wound Healing Applications
Authors: Bayraktar Sema , Üstün Cansu , Kehr Nermin Seda 
Published: December 2023

AbstractOxygen (O2) delivery biomaterials have attracted great interest in the treatment of chronic wounds due to their potential applications in local and continuous O2 generation and delivery, improving cell viability until vascularization occurs, promoting structural growth of new blood vessels, simulating collagen synthesis, killing bacteria and reducing hypoxia‐induced tissue damage. Therefore, different types of O2 delivery biomaterials including thin polymer films, fibers, hydrogels, or nanocomposite hydrogels have been developed to provide controlled, sufficient and long‐lasting O2 to prevent hypoxia and maintain cell viability until the engineered tissue is vascularized by the host system. These biomaterials are made by various approaches, such as encapsulating O2 releasing molecules into hydrogels, polymer microspheres and 3D printed hydrogel scaffolds and adsorbing O2 carrying reagents into polymer films of fibers. In this article, different O2 generating sources such as solid inorganic peroxides, liquid peroxides, and photosynthetic microalgae, and O2 carrying perfluorocarbons and hemoglobin are presented and the applications of O2 delivery biomaterials in promoting wound healing are discussed. Furthermore, challenges encountered and future perspectives are highlighted.
A novel missense variant in OTUD5 causes X‐linked multiple congenital anomalies‐neurodevelopmental syndrome
Authors: Tian Weifang , Li Haiyu , Li Ying , Guo Jing , Wang Handuo , Yang Bo , Li Pengyun , Cui Xueyin , Liu Ling 
Published: December 2023

AbstractBackgroundThe OTUD5 gene encodes a deubiquitinating enzyme (DUB) of the OTU family. Variants of OTUD5 are associated with X‐linked multiple congenital anomalies‐neurodevelopmental syndrome (MCAND). The case described in this study expands the clinical and molecular spectrum of OTUD5.MethodsTrio‐based clinical exome sequencing (trio‐CES) was performed on a Chinese boy with a clinical phenotype and both of his parents. Sanger sequencing was employed for validation of the variant detected.ResultsThe patient presented with characteristic facial features, intellectual disability, motor/language/cognitive, and global developmental delays, limb contractures, and kidney abnormalities, and trio‐CES identified a de novo missense variant, c.1305T>A, of the OTUD5 gene.DiscussionWe describe OTUD5 gene variation in the Chinese population, with the first report of this variant. Additionally, we provide a comprehensive summary of all published cases of MCAND to date, in order to elucidate the primary clinical features of the syndrome and the variability in phenotype severity. This case expands the genetic and clinical phenotypic spectrum of OTUD5‐associated MCAND.
The Ablation of Sensory Neurons Expressing the Nav1.8 Sodium Channel Improves Glucose Homeostasis and Amplifies the GLP‐1 Signaling in Obese Female Mice
Authors: Romaní‐Pérez Marina , Bullich‐Vilarrubias Clara , López‐Almela Inmaculada , Sanz Yolanda 
Published: December 2023

ScopeSensory neurons expressing the sodium channel Nav1.8 contain a repertoire of receptors for nutrient, hormonal, and inflammatory ligands. However, their function in key regulators of energy homeostasis control is not well understood and is completely unexplored in females.Methods and resultsMice lacking neurons expressing the sodium channel Nav1.8 were generated using an ablation strategy based on cre recombinase‐mediated expression of diphtheria toxin fragment A (DTA) (Nav1.8‐cre/DTA mice) to investigate whether these neurons modulate body weight, food intake, gut hormone secretion, gastrointestinal transit, and glucose tolerance in response to nutrient challenges in a sex‐dependent manner. Male Nav1.8‐cre/DTA mice show resistance to gain weight in response to high‐fat high‐sugar diet (HFHSD), whereas females lacking Nav1.8+ neurons have improved oral glucose tolerance accompanied by higher insulin levels and attenuated glucagon secretion after an oral glucose load. Female Nav1.8‐cre/DTA mice also show higher fasting and postprandial glucagon like peptide‐1 (GLP‐1) levels with an increased number of GLP‐1‐positive cells. Finally, ablation of Nav1.8‐expressing neurons accelerates the gastrointestinal transit in female mice under HFHSD.ConclusionThis data demonstrates sex‐dependent differences in the Nav1.8‐mediated regulation of energy metabolism, and provides new insights that may help in the design of sex‐specific neuromodulation therapies for metabolic disorders induced by diets rich in fats and simple sugars.
Egg Yolk Lipids Alleviated Dextran Sulfate Sodium‐Induced Colitis by Inhibiting NLRP3 Inflammasome and Regulating Gut Microbiota
Authors: Xiao Nanhai , He Wen , Chen Shuping , Yao Yao , Wu Na , Xu Mingsheng , Du Huaying , Zhao Yan , Tu Yonggang 
Published: December 2023

AbstractThe increasing incidence of inflammatory bowel disease (IBD) has become a global phenomenon. Egg yolk lipids are one of the essential dietary foods, but its effects on intestinal immunity remain unclear. Here, egg yolk lipids are obtained using ethanol extraction and a total of 601 kinds of lipids are detected via lipidomics, including 251 kinds of triglycerides, 133 kinds of phosphatidylcholines, 44 kinds of phosphatidylethanolamines. Then, the study finds that egg yolk lipids significantly alleviate dextran sulfate sodium‐induced colitis and reduce the production of inflammatory factors. Meanwhile, egg yolk lipids also maintain intestinal barrier integrity and decrease lipopolysaccharide translocation by alleviating intestinal structure damage and increasing the numbers of goblet cells and mucin 2. Mechanistically, egg yolk lipids attenuate colitis by inhibiting the assembly and activation of NLRP3 inflammasome. Moreover, the study also finds that egg yolk lipids reverse gut microbiota dysbiosis referring to increased relative abundance of Bacteroides acidifaciens and decrease relative abundance of Akkermansia muciniphila, as well as increased short chain fatty acids concentration in the gut. Together, the study elucidates the anti‐colitis effect of egg yolk lipids and provides positive evidences for egg yolk lipids involving in dietary strategy and IBD therapy.
Rickets and the industrial revolution in France: The example of Provence
Authors: Perrin Marie , Schmitt Aurore , Ardagna Yann 
Published: December 2023

AbstractThis article aims to estimate the prevalence of rickets and its development during the Industrial Revolution in southeastern France through the study of a large skeletal collection from two recently excavated sites in La Ciotat and Marseille. In total, 790 individuals were selected based on their state of preservation: 556 adults and 234 nonadults. All individuals were systematically examined for macroscopic paleopathological evidence of rickets, based on 13 features indicative of vitamin D deficiency. Rickets was rare in our population, with only 3% of the sample showing signs of the disease. Individuals who died during childhood were more likely to present lesions associated with rickets: 7.7% of the nonadult population show signs of rickets against 1.1% of the adult one (Fisher's exact test: p < 0.001). Moreover, these lesions generally indicated early stages with mechanical bowing of long bones being particularly rare, unlike metaphyseal deformities. Far from the expected increase described by medico‐historical literature, incidence was low and showed no change from the 16th to the 20th century. Furthermore, an increase in residual cases in adults results suggest better survival of vitamin D deficiency, which could reflect better handling of the disease. This is the first study dealing with rickets during the Industrial Revolution in France, and based on osteological material, forthcoming analyses should now focus on the incorporation of radiographic and microscopic criteria to further validate our cases and working hypotheses. Additionally, future research could benefit from the inclusion of a broader sample of individuals from early and late modern contexts, but also from the consideration of local medieval contexts providing a detailed overview that could highlight secular changes over a long period.