bluuebunny/crossref_metadata_2025_split huggingface dataset:
Kasper König (1943-2024)
Authors: Buchloh Benjamin H. D. 
Published: January 2025

Abstract
The article examines the influential legacy of curator and editor Kasper König (1943–2024), focusing particularly on his groundbreaking editorial work at the Nova Scotia College of Art and Design in the early 1970s. Buchloh traces König's evolution from co-founding the publishing house Gebrüder König with his brother in 1967 to his pivotal role in developing the Nova Scotia Series. The article highlights König's commitment to interdisciplinary approaches, particularly through publishing projects that bridged visual art, performance, architecture, dance, and music. Key publications discussed include documentation of Wittgenstein's architecture, Claes Oldenburg's theatrical works, and volumes dedicated to artists like Steve Reich, Simone Forti, and Yvonne Rainer. Buchloh emphasizes König's democratic-anarchist aesthetic philosophy, which privileged artists’ direct communication through primary documents while avoiding interpretive commentary. The piece concludes by examining König's role in documenting institutional critique through Hans Haacke's censored works and his final project with Michael Snow, suggesting how König's editorial practice consistently sought to transform cultural production into moments of potential social change.
Tacita Dean and the Air Outside
Authors: Hornby Louise 
Published: January 2025

Abstract
This is an essay about finding space to breathe in the clouds. It begins with Tacita Dean's chalk drawings of clouds in Los Angeles—themselves large billowing forms of white dust on slate—that reveal the irreducible thereness of clouds, unconnected to anything but themselves and the movement of air. Dean renders clouds as impermanent, arial residue—chalk dust and reflected light—whose exchange of fungibility and form is constituted by acts of erasure and amassing. Dean's clouds appear in Ali Smith's novel Spring, where their permanent changeability provides a space to breathe in the midst of catastrophic loss, solacing the mourner with the continued presence of the world after death. The breathing space of the clouds, the possibility of difference forged through loss, is the starting point for the leap of faith that acknowledges the existence of a world that is not ours to have, not ours to occupy; a world that came before and whose exteriority makes breath and its absence possible, producing the twinned conditions of love and mourning.
Astonishment, Outrage, Despair
Authors: Scott Joan 
Published: January 2025

Abstract
The language my friends and I are using to describe the outcome of Tuesday's elections combines astonishment, outrage, and a large dose of despair. Astonishment that a convicted felon, a twice impeached politician, a vicious misogynist, a racist, homophobe, liar, and cheat, who is a stated enemy of democracy, managed to secure the popular vote for a Republican presidential candidate for the first time since 2004 and—against so many predictions—win all of the states required to carry the electoral college by a significant margin. Along with his victory came control of the Senate and also—at this moment—likely the House of Representatives. The Supreme Court is already stacked with his allies, having ruled in his favor in many of the legal cases brought against his last acts as president. All branches of the government, in other words, are now in the hands of the neo-fascists who have extensive plans to dismantle what remains of American democracy. And make no mistake, they will implement their Project 2025. Even those of us in relatively comfortable positions, who live in “blue” states, will feel the impact of the abolition of the Department of Education; the assignment of health services to the vaccine-denying Robert Kennedy Jr.; the cost-cutting mania of Elon Musk; and the deregulation of what climate controls have managed to be implemented during the Biden administration.
Liberty, the People, and Republican Constitutionalism in Cicero’s Pro Rabirio perduellionis reo
Authors: Clarke Michelle T. 
Published: January 2025

Abstract
This article examines Cicero’s treatment of libertas and its constitutional underpinnings in Pro Rabirio perduellionis reo. In Pro Rabirio, Cicero offers a concentrated discussion of libertas in which he downplays its relationship with popular institutions and procedures and emphasizes instead its strong correlation with social and political consensus. Indeed, for Cicero, libertas is more closely associated with the qualitative characteristics of peaceable association than any particular constitutional order. By characterizing libertas as an experience of calm security that goods citizens enjoy when they are consistently and effectively protected against by injury at the hands of moral degenerates, Cicero makes it possible to distance libertas from provocatio and auxilium, the two major legal and institutional mechanisms associated with libertas in the Roman context, and forge a much stronger connection with the self-regulating activity of the Roman ruling elite.
History as Political Philosophy: Republican Rome as the Best Form of Government in Livy’s Third Decade
Authors: West David T. 
Published: January 2025

Abstract
While scholarship on Livy’s political thought has concentrated on the 1st decade, this article takes up the 3rd decade to argue that Livy makes the case for Republican Rome at the time of the 2nd Punic War as the best form of government. The excellence of Republican Rome is seen in its superiority to the imaginary cities of Greek political theory, and in its mixed constitution, which provides remedies for the pitfalls of the simple forms of democracy and aristocracy. Livy makes the latter case through allusions to Thucydides, whose implications I draw forth to show that Livy is contrasting Republican Rome with Athens and Sparta, and comparing Scipio Africanus with Alcibiades. Livy’s claim that wisdom is to be found in the study of the past, and his preference for the concrete as a means of investigating politics, suggest that his history is a form of political philosophy.
Helping Cato? How to Improve the Roman Case against Greek Culture
Authors: Ambler Wayne 
Published: January 2025

Abstract
The Romans’ conquest of Syracuse and other Greek cities led to a fascinating encounter between two of the sources most at the heart of what we often call ‘Western Civilization’. Notwithstanding the Greeks’ achievements, several thoughtful Romans were fearful that an influx of Greek sophistication would weaken the Roman Republic. Cato the Elder was the most prominent of this group, and we begin here with a review of the limited remaining evidence of his thinking. We then look further afield for allies who might develop his case further. We find them, ironically enough, among the Greeks themselves.
A cross-sectional survey of psychiatrists’ experiences of using telepsychiatry during the COVID-19 pandemic and the relationship with burnout in selected high, middle, and low-income countries
Authors: Tawfik Fairouz , Ryland Howard , Yosef Mostafa , Morsy Mahmoud , Kaligis Fransiska , Noël Camille , Abdulhakim Mohamed , Mazereel Victor , Palavra Irena Rojnić , Prošev Andrej , Fiorillo Andrea , Sampogna Gaia , Durán Xenia Margarita , Jurado Jesús David Martínez , Ibrahim Islam 
Published: January 2025

Background: The COVID-19 pandemic necessitated substantial modifications in the delivery of patient care on a global scale. Telemedicine-based care services were implemented worldwide to maximize access to healthcare systems. Aims: This study aimed to investigate the use of and satisfaction with telepsychiatry services implemented during the COVID-19 pandemic by psychiatrists across low, middle, and high income countries, and to assess levels of burnout among psychiatrists providing telepsychiatry services in different settings and countries. We hypothesized that use of telepsychiatry will have increased during the pandemic and is associated with increased risk of burnout. Methods: A cross-sectional survey was conducted from October 2020 to June 2021 on psychiatrists practicing in Egypt, United Kingdom, Croatia, Belgium, Indonesia, Italy, and El Salvador. Participants were asked to provide sociodemographic data and to complete a questionnaire developed ad-hoc by the authors on telepsychiatry use, the Modified Arizona Telemedicine Program Satisfaction (MATPS) survey and the Oldenburg Burnout Inventory questionnaire. Results: A total of 347 participants completed the survey. Sixty three percent indicated that they had not utilized teleservices for clinical consultation or academic purposes prior to the COVID-19 pandemic. A substantial shift was observed during the pandemic, with this percentage increasing to 98%. Over two-thirds of psychiatrists expressed satisfaction with the visual (76%) and audio (77%) aspects of teleconsultation. No significant correlation was found between burnout and satisfaction. While older age was negatively correlated with burnout levels, years of experience showed a positive correlation with levels of burnout. Conclusion: While there was an increased acceptance and satisfaction with teleconsultation, a persistent preference for in-person consultations remained. The study did not find a correlation between satisfaction in telepsychiatry and levels of burnout. Moreover, increasing age was correlated with lower burn out rate, whereas a correlation between years of experience and heightened levels of burnout was evident.
Impact of surgical specialization on long-term survival after emergent colon cancer resections
Authors: Engdahl Jenny , Öberg Astrid , Bech-Larsen Sandra , Öberg Stefan 
Published: January 2025

Background: The impact of surgical specialization on long-term survival in patients undergoing emergent colon cancer resections remains unclear. Method: A retrospective analysis was conducted on all patients who underwent emergent colon cancer resections at a secondary care hospital between 2010 and 2020. The most senior surgeon performing the procedures was classified as colorectal surgeon (CS) or non-colorectal surgeon (NCS). NCS was further divided into acute care surgeons (ACSs) or general surgeons (GSs). Overall survival (OS) and cancer-free survival (CFS) were compared in patients operated by surgeons with different specializations. Results: A total of 235 emergent resections were performed during the study period, of which 99 (42%) were performed by CS and 136 (58%) by NCS. In adjusted Cox regression analyses, OS and CFS were similar in patients operated on by CS and NCS (hazard ratio (HR) for OS: 1.02 (0.72–1.496), p = 0.899 and HR for CFS: 0.91 (0.61–1.397), p = 0.660). Similarly, OS and CFS were equivalent in patients operated by ACS and CS (HR for OS: 1.10 (0.75–1.62), p = 0.629 and HR for CFS: 1.24 (0.80–1.92), p = 0.343). However, patients operated by GS had significantly shorter OS and CFS (HR for OS: 1.78 (1.05–3.00), p = 0.031 and HR for CFS: 1.83 (1.02–3.26), p = 0.041) compared with those operated by ACS and CS. Conclusion: Long-term survival after emergent colon cancer resections was similar in patients operated on by CS and NCS, and the subgroup of ACS, indicating equivalent comparable surgical quality. The less favorable poorer survival observed for patients operated on by GS may possibly be due to less frequent exposure to colorectal and emergent surgery.
The utilization of microbial cell-free DNA next-generation sequencing for the detection of human herpesvirus-8 in a quaternary care center
Authors: Berger Rebecca , Jacobe Jennifer , Centeno Fernando H. , Lasco Todd , Al Mohajer Mayar 
Published: January 2025

Background: Human herpesvirus-8 (HHV8) can present with cutaneous or extracutaneous manifestations. While violaceous skin lesions characterize cutaneous Kaposi sarcoma, extracutaneous HHV8 is challenging to diagnose due to nonspecific symptoms. Objectives: We evaluated the role of microbial cell-free DNA next-generation sequencing (mcfDNA NGS) in diagnosing HHV8-related illness. Design: Retrospective analysis. Methods: Between 2017 and 2024, we reviewed the medical charts of 10 immunosuppressed patients at a quaternary care center who had positive HHV8 mcfDNA NGS results. Results: The clinical and laboratory turnaround times of mcfDNA NGS were 3 and 1 days, respectively (8.5 and 7 days for immunohistochemistry vs 5.5 and 2 days for serum HHV8 polymerase chain reaction). Eight patients received HHV8-related diagnoses, while two had unrelated conditions. Management changed in six patients post-testing due to outpatient specialist referral or adjusting antimicrobials. Conclusion: mcfDNA NGS can aid clinicians in identifying HHV8-related diseases before tissue sampling and adjusting treatment plans in patients with nonspecific disease manifestations.
Association of Preoperative Cartilage T1ρ Values With Progression of Knee Osteoarthritis 10 Years After Anatomical Double-Bundle ACL Reconstruction: Follow-up of a Previous Prospective Study
Authors: Watanabe Shotaro , Sakamoto Takuya , Horii Manato , Kimura Seiji , Yamaguchi Satoshi , Ohtori Seiji , Sasho Takahisa 
Published: January 2025

Background: The factors contributing to osteoarthritis progression after anterior cruciate ligament (ACL) injury and reconstruction (ACLR) are not fully understood. Quantitative magnetic resonance imaging (MRI) offers a noninvasive way to evaluate cartilage biochemical composition using T1ρ mapping, thereby detecting early cartilage degeneration. The specific impact of preoperative quantitative MRI on long-term outcomes after ACLR remains underreported. Purpose/Hypothesis: The purpose of this study was to investigate the effects of various factors, including preoperative cartilage T1ρ values, on the 10-year outcomes after ACLR. It was hypothesized that individual differences in baseline cartilage degeneration would influence osteoarthritis progression at 10 years postoperatively. Study Design: Case series; Level of evidence, 4. Methods: This case series involved 13 patients with primary ACL injury who underwent anatomical double-bundle ACLR using hamstring tendon autograft between April 2012 and August 2013. All patients underwent preoperative quantitative MRI using a 3.0-T scanner with an 8-channel knee coil. Cartilage was divided into 18 compartments for compositional analysis, and average T1ρ values were calculated for each compartment. At the 10-year follow-up, 9 of the patients were available for patient-reported outcome (PRO) measures and radiographs. Results: The 9 patients (6 female, 3 male) had a mean age of 26.4 years and a mean body mass index of 23.3 at surgery. All patients exhibited favorable PRO scores at the 10-year follow-up, but 5 patients showed osteoarthritis progression according to Kellgren-Lawrence (KL) grade. Although preoperative T1ρ values did not significantly correlate with PRO scores, patients with KL grade progression had significantly higher preoperative T1ρ values in the posterolateral tibial cartilage than those without progression ( P = .04). Conclusion: Ten years after anatomical double-bundle ACLR, most patients reported favorable outcomes. Preoperative T1ρ values were not directly correlated with PROs, although the presence of a patient subset with progressive KL grades suggests that preoperative posterolateral tibial cartilage condition may influence long-term osteoarthritis progression.
AdipoR1 enhances the radiation resistance via ESR1/CCNB1IP1/cyclin B1 pathway in hepatocellular carcinoma cells
Authors: Gan Yuhan , Zhu Linhui , Li Yimo , Ge Ruoting , Tian Jiahe , Chen Yuxin , He Xiang , Ma Shumei , Liu Xiaodong 
Published: January 2025

Abstract
Hepatocellular carcinoma is one of the most common malignant tumors, and radiotherapy plays a pivotal role in its therapeutic regimen. However, radiotherapy resistance is the main cause of therapeutic failure in patients. Our previous study revealed that Adiponectin Receptor 1 (AdipoR1) is involved in regulating radiation resistance in liver cancer patients treated with stereotactic body radiotherapy. To explore the mechanism, we performed high-throughput transcriptome sequencing of hepatocellular carcinoma cells with stable knockdown of AdipoR1. KEGG enrichment analysis indicated that the cell cycle and ubiquitination degradation pathways may be involved in the regulation of radiation resistance by AdipoR1.The knockdown of AdipoR1 can attenuate the radiation-induced G2/M phase arrest through cyclin B1.By the ubiquitination IP assay and a rescue experiment, we confirmed that CCNB1IP1 regulated the ubiquitination and degradation of cyclin B1. Combined with information from transcription factor database and AdipoR1 transcriptome sequencing, these results showed that estrogen receptor 1 (ESR1) may be a transcription factor of CCNB1IP1. We found that AdipoR1 promoted the translocation of ESR1 from the cytoplasm to the nucleus, and ESR1 inhibited the transcription of CCNB1IP1.Therefore, we propose that AdipoR1 regulates the ubiquitination level, cell cycle progression, and radiation resistance of HCC cells through the “AdipoR1 /ESR1/CCNB1IP1/cyclin B1” axis. This study will promote the development of novel targeted radiosensitizing drugs.
FPR1 affects acute rejection in kidney transplantation by regulating iron metabolism in neutrophils
Authors: Li Peiyuan , Ji Wenbin , Zhang Baotong , Jia Haowen , Wang Jinmiao , Sun Zhaonan , Wang Yifan , Wang Weiwei , Qi Feng 
Published: January 2025

Abstract

Background
Acute rejection (AR) is one of the significant factors contributing to poor prognosis in patients following kidney transplantation. Neutrophils are the main cause of early host-induced tissue injury. This paper intends to investigate the possible mechanisms of neutrophil involvement in acute rejection in renal transplantation.

Methods
Samples were analyzed for their relationship with immune cells using CIBERSORT. WGCNA was used to identify modules with high relevance to neutrophils and hub genes in the modules were extracted. The effect on neutrophil function after blocking formyl peptide receptor 1 (FPR1) was tested in vitro experiments. The effects of blocking FPR1 on neutrophil function as well as acute rejection were tested in vivo after constructing a mouse kidney transplant model.

Results
The proportion of neutrophils was higher in the AR group than in the non-rejection group, and FPR1 was identified as an important gene in the regulation of acute rejection in kidney transplantation by neutrophils. At the cellular level, blocking FPR1 inhibited the activation of the ERK1/2 pathway, decreased ferrous ion content, affected the expression of iron metabolism-related proteins, and suppressed the formation of NETs. In the acute rejection model of renal transplantation, blockade of FPR1 decreased graft neutrophil infiltration and NETs content. Meanwhile, blocking FPR1 attenuated graft injury during acute rejection.

Conclusion
This study found that FPR1 might be an important molecule involved in neutrophils during acute rejection of kidney transplantation, explored the relationship between kidney transplantation and neutrophils, and provided potential treatment methods for clinical practice.
Increased PD-1 expression in livers associated with PD-1-antibody-induced hepatotoxicity
Authors: Saarela Miro , Parviainen Essi , Lleo Ana , di Tommaso Luca , Raunio Hanna , Kankaanranta Krista , Vuopala Katri , Rönkä Aino , Nurmenniemi Sini , Kallio Raija , Jukkola Arja , Selander Katri S. 
Published: January 2025

Abstract
Vanishing bile duct syndrome (VBDS) is a serious drug induced liver injury characterized by chronic cholestasis and loss of intrahepatic bile ducts. VBDS has been reported also following checkpoint inhibitor treatment. We compared CD3 + , CD4 + , CD8 + , CD20 + , CD57 + , PD-1 + and PD-L1 + lymphocyte infiltrates in liver biopsies of patients that encountered VBDS (n = 2) or hepatotoxicity (n = 3) after pembrolizumab (n = 4) or nivolumab (n = 1) treatment with samples from normal liver (n = 10), non-alcohol steatohepatitis (NASH, n = 10), primary biliary cholangitis (PBC, n = 10) or pembrolizumab-treated patients without adverse events (n = 2). Notably, none of the cancer patients had primary nor metastatic liver tumors. We also studied direct growth effects of pembrolizumab on primary human intrahepatic biliary epithelial cells (HIBEpiC) in vitro. Liver sections of all checkpoint inhibitor- treated patients exhibited significantly higher CD3 + infiltration than normal livers, and significantly higher PD-L1 + , CD4 + and CD8 + infiltration, than other groups. PD-1 + infiltration was significantly increased in livers of patients with severe hepatic adverse event. CD57 + infiltration was similar in normal livers, NASH- and PBC groups, but highly increased in the checkpoint inhibitor-treated patients. Immune cell infiltrates were similar between NASH and normal livers. PBC samples had significantly higher CD3 + , CD4 + , CD8 + and CD20 + infiltrates than normal livers. HIBEpiC express PD-L1 but pembrolizumab did not affect their viability in vitro. Our findings suggest that VBDS is not due to direct cytotoxicity of checkpoint inhibitors and that the immunological attack against livers induced by these drugs is different from other cholestatic liver conditions.
Biological insight: Checkpoint inhibitors upregulate PD-1 and PD-L1, as well as cytotoxic CD57 + cells in the non-cancerous liver tissues and this may be associated with checkpoint inhibitor-induced hepatotoxicity.