bluuebunny/crossref_metadata_2025_split huggingface dataset:
Fracture morphology and strength characteristics of poly-lactic acid and poly-ethylene terephthalate glycol composites combined with taguchi method and response surface methodology
Authors: Jain Akash , Sahai Ankit , Sharma Rahul Swarup 
Published: December 2023

The emergence of additive manufacturing has enabled scientists to efficiently construct complex geometries, facilitating the development of novel, high-impact energy-absorbing structures suitable for a wide range of industrial applications. The present study conducted flexural and impact test to quantitatively assess the energy absorption capabilities of polymer composites fabricated through fused filament fabrication. Specifically, the polymer composites investigated were multi-walled carbon nanotubes reinforced poly-lactic acid, carbon fibre reinforced poly-ethylene terephthalate glycol, and carbon fibre reinforced poly-lactic acid. The investigation also examined the influence of different infill patterns and nozzle hole diameters on the polymer composites. The investigation depicts that by altering the process parameters, the flexural strength is improved from 21.079 MPa to 70.653 MPa by 235.18%. The experimental study of impact specimens utilising the Izod impact test demonstrates that the rectilinear infill pattern and a nozzle hole diameter of 0.6 mm result in the highest energy absorption of 37.76 kJ/m2 for carbon fibre reinforced poly-lactic acid. The study revealed that the energy absorption of the specimens was significantly influenced by both the independent and interaction effects of process variables. The application of the fused filament fabrication demonstrates an improved energy absorption, making it suitable for manufacturing of vehicle and aircraft components.
Supporting the festival industry in troubled times: Higher education research and collaboration with festivals in South Africa during COVID-19
Authors: Snowball Jen , Drummond Fiona , Tarentaal Delon 
Published: December 2023

This case study presents a critical reflection on the way COVID-19 lockdowns in 2020-2022 brought the festival industry in South Africa closer to higher education (HE) via a new and innovative collaboration. The research design allowed an international team to facilitate knowledge sharing and research support during a very challenging time for the industry. The project saw the development of a collaboration with seven festivals across South Africa. During the 15 months project, the collaboration allowed participants to build a new knowledge base - and a collaborative network - to survive the challenging times. Rather than a more extractive, top-down approach that saw festivals as “research subjects”, they were involved as research partners. Cultural organisations and members of the South African team acted as intermediaries, who used their existing networks and reputations to build a collaborative, trust-based relationship between industry partners and researchers where mutually beneficial outcomes were possible. The project thus became part of the South Africa festival ecosystem, creating opportunities for collaboration and knowledge exchange between festivals, cultural producers and academic researchers. The outcomes of the research helped to build a stronger creative economy and support its future development.
Intravesical Textiloma: A Rare Complication Following Laparoscopic Inguinal Hernia Repair – A Case report
Authors: El Omri Ghassane , Rais Hamza , Rachid Moussaab , Guennouni Meryem , Heddat Abdeljalil 
Published: December 2023

Introduction: Today, surgical errors are becoming less and less frequent, thanks to the development of new techniques and the choice of different approaches. Nevertheless, they are still possible, and it is important to mention them in order to prevent them and avoid their recurrence. Case Presentation: We report a case of intravesical textiloma, rarely observed in urological surgery, in an 80-year-old patient who underwent laparoscopic inguinal hernia repair and presented to a urological consultation with hematuria and irritative lower urinary tract signs. Abdominal ultrasound revealed a hyperechoic tissue-like formation in the posterior wall of the bladder. The diagnosis of a bladder tumor was therefore raised, and cystoscopy was performed, which revealed an intravesical textiloma. All foreign bodies were removed endoscopically, and the patient had a good post-operative outcome. Conclusion: The rarity of the urological location of textilomas and the importance of their prevention remain a goal in surgery, whatever the specialty.
Nonfluoroscopic 3D Image Guidance System Reduces Navigation Times Through Five 3D-Printed Iliofemoral Vascular Phantoms
Authors: Braga Daniel , Ducaud Cristobal , Camardo Andrew , Hofacker Hannah , Goel Vikash , Beasley Robert 
Published: December 2023

Purpose: To assess the potential adjunctive role of a 3D electromagnetic (EM) navigational system for use in above-knee vessels afflicted with peripheral artery disease (PAD). Peripheral artery disease can be challenging to operators encountering significant vessel tortuosity, calcium, and stenoses, which may require prolonged procedure times and excessive use of nephrotoxic iodinated contrast when performed with conventional fluoroscopy. Materials and Methods: Following appropriate ethical oversight, five 3D-printed bench phantoms modeling tortuous calcified PAD were created based on source CTA (computed tomography angiography) data sets from real patients. Investigational software was developed based on a commercially available aortic EM navigation platform (Intraoperative Positioning System [IOPS]; Centerline Biomedical, Inc., Cleveland, Ohio), with patient-specific structural maps of vessel lumens and calcification. Using a sensorized prototype 6 French (Fr) catheter and 0.035” guidewire, 15 interventionalists traversed each phantom using the EM platform as well as 2D simulated fluoroscopy-like image guidance and the times were recorded. Participants completed a 10-item standard system usability scale (SUS) questionnaire (score 1–5, 5= strongly agree) evaluating system usability and user satisfaction. Navigation times and SUS scores were compared with a 1-tailed statistical t test. Results: Participants demonstrated a statistically significant reduction in navigation times using EM guidance, performing 0.7 minutes (42 seconds) faster on average ( P < .001), corresponding to a 25% average relative reduction. Participants reported sufficiently high levels of usability satisfaction, with a mean SUS score of 4.29 ( P < .001), exceeding the acceptance criterion (score ≥3.5). Conclusion: This preclinical phantom study highlights the future potential of Centerline Biomedical’s EM navigation technology as a possible adjunct to fluoroscopy for highly precise visualization and navigation of PAD-afflicted vasculature. Clinical Impact This preclinical proof-of-concept study highlights the feasibility of EM navigation not only for branch vessel cannulation, but also for inline navigation of peripheral vessels afflicted with calcified plaques via benchtop iliofemoral phantom simulations. The navigation platform studied addresses the need for improvements in EM technology through modelling algorithms that facilitate 3D visualization of calcified plaque in any projection in real time, in addition to sensorization of both catheter and guidewire in a compact 6Fr system.
Familial hepatic rupture in vascular Ehlers–Danlos syndrome in pregnancy with atypical thromboses
Authors: Patel Jesal , Neville Cai , Kumar Raj , Grey-Davies Elisabeth , Hutt Renata , van Dijk Fleur S. , Chan Li Yuan , Walter Edward 
Published: December 2023

Lesson This case highlights the importance of genetic testing over fibroblast testing and presents the first published thromboelastometry data in vascular Ehlers–Danlos syndrome.
Multimorbidity and Blood Pressure Control in Patients Attending Primary Care in Canada
Authors: Nguyen Tu N. , Kalia Sumeet , Hanlon Peter , Jani Bhautesh D. , Nicholl Barbara I. , Christie Chelsea D. , Aliarzadeh Babak , Moineddin Rahim , Harrison Christopher , Chow Clara , Fortin Martin , Mair Frances S. , Greiver Michelle 
Published: December 2023

Background: There has been conflicting evidence on the association between multimorbidity and blood pressure (BP) control. This study aimed to investigate this associations in people with hypertension attending primary care in Canada, and to assess whether individual long-term conditions are associated with BP control. Methods: This was a cross-sectional study in people with hypertension attending primary care in Toronto between January 1, 2017 and December 31, 2019. Uncontrolled BP was defined as systolic BP ≥ 140 mmHg or diastolic BP ≥ 90 mmHg. A list of 11 a priori selected chronic conditions was used to define multimorbidity. Multimorbidity was defined as having ≥1 long-term condition in addition to hypertension. Logistic regression models were used to estimate the association between multimorbidity (or individual long-term conditions) with uncontrolled BP. Results: A total of 67 385 patients with hypertension were included. They had a mean age of 70, 53.1% were female, 80.6% had multimorbidity, and 35.7% had uncontrolled BP. Patients with multimorbidity had lower odds of uncontrolled BP than those without multimorbidity (adjusted OR = 0.72, 95% CI 0.68-0.76). Among the long-term conditions, diabetes (aOR = 0.73, 95%CI 0.70-0.77), heart failure (aOR = 0.81, 95%CI 0.73-0.91), ischemic heart disease (aOR = 0.74, 95%CI 0.69-0.79), schizophrenia (aOR = 0.79, 95%CI 0.65-0.97), depression/anxiety (aOR = 0.91, 95%CI 0.86-0.95), dementia (aOR = 0.87, 95%CI 0.80-0.95), and osteoarthritis (aOR = 0.89, 95%CI 0.85-0.93) were associated with a lower likelihood of uncontrolled BP. Conclusion: We found that multimorbidity was associated with better BP control. Several conditions were associated with better control, including diabetes, heart failure, ischemic heart disease, schizophrenia, depression/anxiety, dementia, and osteoarthritis.
What to expect from primary inferior oblique overaction after esotropia surgery
Authors: Freitas-da-Costa Paulo , Alves Hélio , Santos-Silva Renato , Falcão-Reis Fernando , Breda Jorge , Magalhães Augusto 
Published: December 2023

Abstract
Background
Overelevation in adduction is common in patients with primary esotropia. This study evaluates the variation in ocular motility pattern in patients with primary inferior oblique (IO) muscle overaction after esotropia surgery.

Methods
The medical records of consecutive patients who underwent surgery for infantile, partially accommodative, and basic esotropia over eleven years and had at least one year of follow-up were reviewed. Patients with primary inferior oblique muscle overaction (IOOA) presented at baseline or during follow-up were selected and divided according to the first surgery performed concurrently with horizontal rectus surgery: without IO recession (NO-recess), with unilateral IO recession (UNIL-recess), and with bilateral IO recession (BIL-recess). The success (version normalisation or at least 2 points upgrade in severity scale [0–4] in the operated eye), recurrence rates, and the evolution of the non-operated IO muscles were evaluated.

Results
One hundred and ten patients were included – 53 NO-recess, 26 UNIL-recess, and 31 BIL-recess. Medial rectus muscle posterior fixation sutures surgery (PFS) was performed in 88.2% of patients for esotropia. A recession with graded anterior transposition was the weakening IO procedure. In the NO-recess group, 28 (52.8%) patients normalised their mild IOOA after PFS surgery alone. In the UNI-recess group, the success rate was 88.5%, with 16 (61.5%) patients showing worsened IO muscle of the fellow eye, which prompted additional surgery in 10 patients. In the BIL-recess group, all 31 patients improved the adduction pattern of the operated eye for an 80.6% success rate (6 improved marginally).

Conclusion
Graded anterior transposition of the inferior oblique muscle effectively normalises versions. However, it’s frequent for a contralateral overaction to become manifest after unilateral IO surgery.
Application of entire dental panorama image data in artificial intelligence model for age estimation
Authors: Kahm Se Hoon , Kim Ji-Youn , Yoo Seok , Bae Soo-Mi , Kang Ji-Eun , Lee Sang Hwa 
Published: December 2023

Abstract
Background
Accurate age estimation is vital for clinical and forensic purposes. With the rapid advancement of artificial intelligence(AI) technologies, traditional methods relying on tooth development, while reliable, can be enhanced by leveraging deep learning, particularly neural networks. This study evaluated the efficiency of an AI model by applying the entire panoramic image for age estimation. The outcome performances were analyzed through supervised learning (SL) models.

Methods
Total of 27,877 dental panorama images from 5 to 90 years of age were classified by 2 types of grouping. In type 1 they were classified by each age and in type 2, applying heuristic grouping, the age over 20 years were classified by every 5 years. Wide ResNet (WRN) and DenseNet (DN) were used for supervised learning. In addition, the analysis with ± 3 years of deviation in both types were performed.

Results
For the DN model, while the type 1 grouping achieved an accuracy of 0.1016 and F1 score of 0.058, the type 2 achieved an accuracy of 0.3146 and F1 score of 0.2027. Incorporating ± 3years of deviation, the accuracy of type 1 and 2 were 0.281, 0.7323 respectively; and the F1 score were 0.1768, 0.6583 respectively. For the WRN model, while the type 1 grouping achieved an accuracy of 0.1041 and F1 score of 0.0599, the type 2 achieved an accuracy of 0.3182 and F1 score of 0.2071. Incorporating ± 3years of deviation, the accuracy of type 1 and 2 were 0.2716, 0.7323 respectively; and the F1 score were 0.1709, 0.6437 respectively.

Conclusions
The application of entire panorama image data for supervised with classification by heuristics grouping with ± 3years of deviation for supervised learning models and demonstrated satisfactory outcome for the age estimation.
Immune indices and oral health in patients infected with the human immunodeficiency virus
Authors: Yang Yuxiang , Yu Feixue , Fei Yujie , Dong Guangyan , Cao Peilin , Liu Yi 
Published: December 2023

Abstract
Background
The human immunodeficiency virus (HIV) is the causative agent of acquired immunodeficiency syndrome (AIDS). During the incubation period of AIDS, oral manifestations may precede systemic symptoms; therefore, it is vitally important to explore the relationship between HIV and oral health and other indicators. This study aimed to further assess the correlation between demographic risk factors, the dental health of HIV-infected patients, and the correlation of oral health indicators with CD4+ T-cell counts (CTCCs) and HIV viral loads (HIV-VLs).

Methods
Demographic data on 108 HIV-infected patients were first recorded by questionnaire from March 2016 to November 2018. Patients’ dental health and oral lesions were assessed by a dental specialist; in addition, they were tested for CTCCs and HIV-VLs by flow cytometry and NucliSENS EasyQ® HIV-1 virometer. Finally, the links between CTCC, HIV-VL, and the dental health (including oral lesions) of the patients were analyzed.

Results
We found that age, marital status, and body mass index (BMI) were relevant to the patient’s dental health (P < 0.05) and that their oral hygiene was relevant to their dental health (P < 0.05). However, HIV-VL was not directly related to periodontal/dental clinical indicators (P > 0.05). We discovered that the oral lesions in HIV-infected patients were related to decreased CTCCs and increased HIV-VLs (P < 0.05).

Conclusions
We concluded that HIV-infected patients with severely impaired immune function tend to have poor dental health. Moreover, the prevalence of oral lesions was negatively correlated with CTCC and positively correlated with HIV-VL.
Antimicrobial, antioxidant and cytotoxic activities of the leaf and stem extracts of Carissa bispinosa used for dental health care
Authors: Shekwa Wanda , Maliehe Tsolanku Sidney , Masoko Peter 
Published: December 2023

Abstract
Background
Carissa bispinosa (L.) Desf. ex Brenan is one of the plants used traditionally to treat oral infections. However, there is limited data validating its therapeutic properties and photochemistry. The aim of this study was to investigate the protective efficacy of the leaf and stem extracts of C. bispinosa against oral infections.

Methods
The phenolic and tannin contents were measured using Folin-Ciocalteau method after extracting with different solvents. The minimum inhibitory concentrations (MIC) of the extracts were assessed using the microdilution method against fungal (Candida albicans and Candida glabrata) and bacterial (Streptococcus pyogenes, Staphylococcus aureus and Enterococcus faecalis) strains. The 2-diphenyl-1-picrylhydrazyl (DPPH) and ferric reducing power (FRP) models were utilised to assess the antioxidant potential of the extracts. Cytotoxicity of the leaf acetone extract was evaluated using the methylthiazol tetrazolium assay.

Results
The methanol leaf extract had the highest phenolic content (113.20 mg TAE/g), whereas hexane extract displayed the highest tannin composition of 22.98 mg GAE/g. The acetone stem extract had the highest phenolic content (338 mg TAE/g) and the stem extract yielded the highest total tannin content (49.87 mg GAE/g). The methanol leaf extract demonstrated the lowest MIC value (0.31 mg/mL), whereas the stem ethanol extract had the least MIC value of 0.31 mg/mL. The stem methanol extract had the best DPPH free radical scavenging activity (IC50, 72 µg/mL) whereas the stem ethanol extract displayed maximum FRP with absorbance of 1.916. The leaf acetone extract had minimum cytotoxicity with the lethal concentration (LC50) of 0.63 mg/mL.

Conclusions
The results obtained in this study validated the protective effect of C. bispinosa against oral infections.
Exploratory factor analysis of constructs used for investigating research uptake for public healthcare practice and policy in a resource-limited setting, South Africa
Authors: Sigudla Jerry , Maritz Jeanette E. 
Published: December 2023

Abstract
Background
Low-resource settings are often less capable of responding to and implementing available quality research evidence for public healthcare practice and policy development due to various factors. In most low-resource settings, limited empirical evidence is available to help deal with localised factors that contribute to low public health research uptake, particularly from the perspective of key research stakeholders.

Methods
Although the study initially employed a two-phase exploratory sequential approach, this paper focuses on the results generated from a quantitative approach. Considering the determining factors that affect research uptake in the context of low-resource settings, a measuring instrument was developed and its reliability and validity were assessed using an exploratory factor analysis approach.

Results
A total of 212 respondents, according to their job roles and titles, were identified as researchers, front-line workers, programme managers, and directors/senior managers of higher learning institutions, indicating that the three constructs applied in the questionnaire, namely (1) individual factors, (2) organisational factors, and (3) research characteristics, demonstrated relatively high reliability with a Cronbach’s alpha of greater than 0.791.

Conclusion
The study concludes that the instrument can potentially be used to measure factors that affect research uptake in low-resource settings.
Is qPCR always the most sensitive method for malaria diagnostic quality surveillance?
Authors: Koepfli Cristian 
Published: December 2023

AbstractIn many studies to evaluate the quality of malaria diagnosis, microscopy or rapid diagnostic tests (RDT) are compared to PCR. Depending on the method for sample collection and storage (whole blood or dried blood spot), volume of blood used for extraction, volume of DNA used as PCR template, and choice of PCR target (single vs. multi-copy gene), the limit of detection (LOD) of PCR might not exceed the LOD of expert microscopy or RDT. One should not assume that PCR always detects the highest number of infections.
Prevalence and genotype distribution of human papillomavirus infection among women in Jingzhou, China: a population-based study of 51,720 women
Authors: Liu Shun , Mei Bing , Ouyang Yaoling , Li Chengbin 
Published: December 2023

Abstract
Background
Cervical cancer is the fourth most common cancer among women worldwide with a serious threat to women’s health. Persistent infection with high-risk human papillomavirus (HR-HPV) has been identified as the main cause of cervical cancer. This study aimed to evaluate the prevalence and genotype distribution of HR-HPV among women in Jingzhou, Hubei province, China, which is critical for the government to formulate the precision strategies of cervical cancer screening and HPV vaccine innoculation.

Methods
To obtain the baseline data on the population-based prevalence and genotype distribution of HR-HPV infection among age groups and different years, a total of 51,720 women from 2018 to 2022 who went to Jingzhou Hospital Affiliated to Yangtze University for physical examination or gynacological treatment and received HR-HPV DNA genotyping were included in this retrospective study. The possible cervicovaginal infection of 15 high-risk HPV genotypes were analyzed by multiplex fluorescent real-time PCR, including HPV 16, 18, 31, 33, 35, 39, 45, 51, 52, 56, 58, 59, 66, 68 and 82.

Results
The overall high-risk HPV prevalence among 51,720 women was 18.75% (9,698/51,720), and the HPV-positive rate of physical examination group (PEG) was 13.22% (541/4,091), which was lower than the HPV-positive rate of gynacological checkup group (GCG) 19.23% (9,157/47,629), with statistical difference (χ2 = 89.069, P < 0.01). The five most common prevalent genotypes were HPV52 (6.55%), HPV58 (3.41%), HPV16 (2.58%), HPV68 (1.82%) and HPV51 (1.57%). Single HPV infection was the predominant (14.36%), which compared to double (3.34%) and multiple (1.05%) infections. The HPV-positive rate was the highest in the > 60 age group (31.73%), and the lowest in the 31–40 age group (15.46%).

Conclusions
The prevalence of high-risk HPV infection among women in Jingzhou area was 18.75%. HPV52, HPV58 and HPV16 genotypes were the most common. The higher prevalence was in the > 60 and ≤ 20 age group, which showed a “U” shape curve, suggesting the necessity of screening among older women to decrease the mortality of cervical cancer.