bluuebunny/crossref_metadata_2025_split huggingface dataset:
Fully automated 3D body composition analysis and its association with overall survival in head and neck squamous cell carcinoma patients
Authors: Rozynek Miłosz , Gut Daniel , Kucybała Iwona , Strzałkowska-Kominiak Ewa , Tabor Zbisław , Urbanik Andrzej , Kłęk Stanisław , Wojciechowski Wadim 
Published: October 2023

ObjectivesWe developed a method for a fully automated deep-learning segmentation of tissues to investigate if 3D body composition measurements are significant for survival of Head and Neck Squamous Cell Carcinoma (HNSCC) patients.Methods3D segmentation of tissues including spine, spine muscles, abdominal muscles, subcutaneous adipose tissue (SAT), visceral adipose tissue (VAT), and internal organs within volumetric region limited by L1 and L5 levels was accomplished using deep convolutional segmentation architecture - U-net implemented in a nnUnet framework. It was trained on separate dataset of 560 single-channel CT slices and used for 3D segmentation of pre-radiotherapy (Pre-RT) and post-radiotherapy (Post-RT) whole body PET/CT or abdominal CT scans of 215 HNSCC patients. Percentages of tissues were used for overall survival analysis using Cox proportional hazard (PH) model.ResultsOur deep learning model successfully segmented all mentioned tissues with Dice’s coefficient exceeding 0.95. The 3D measurements including difference between Pre-RT and post-RT abdomen and spine muscles percentage, difference between Pre-RT and post-RT VAT percentage and sum of Pre-RT abdomen and spine muscles percentage together with BMI and Cancer Site were selected and significant at the level of 5% for the overall survival. Aside from Cancer Site, the lowest hazard ratio (HR) value (HR, 0.7527; 95% CI, 0.6487-0.8735; p = 0.000183) was observed for the difference between Pre-RT and post-RT abdomen and spine muscles percentage.ConclusionFully automated 3D quantitative measurements of body composition are significant for overall survival in Head and Neck Squamous Cell Carcinoma patients.
Transanal total mesorectal excision: single center study on risk factors for major complications
Authors: Xu Zhiwen , Zhu Jingtao , Bai Haoyu , Xiao Liangbin , Wang Tinghao , Lin Hexin , Hong Qingqi , You Jun 
Published: October 2023

PurposeTransanal total mesorectal excision (TaTME) as a novel surgical approach for mid and low rectal cancer has gained significant research interest in recent years. The main objective of this study is to identify the risk factors associated with major complications after TaTME and evaluate the perioperative clinical outcomes.MethodsA retrospective analysis was performed on the clinical data of patients with mid-to-low rectal cancer who underwent TaTME surgery and were admitted to the First Affiliated Hospital of Xiamen University from January 2018 to May 2023. Univariate and multivariate regression methods were employed to analyze the risk factors influencing the occurrence of major complications (Clavien-Dindo III-V).ResultsThis study included a total of 179 eligible cases, with no perioperative deaths. The overall incidence of early complications was 25.1%, with a rate of 10.1% for mild complications and 15.0% for major complications. The postoperative anastomotic leakage rate within 30 days was 6.7%. Multivariate analysis demonstrated that male (P=0.030), pathological T ≥ 3 (P=0.018) and manual anastomosis (P=0.009) were independent risk factors for the development of major complications after surgery.ConclusionIn this study, the incidence of early complications and anastomotic leakage rate in TaTME were both relatively low. Male, pathological T stage ≥ 3 and manual anastomosis were independent risk factors for the occurrence of major complications in a cohort of patients with mid and low rectal cancer undergoing TaTME.
Desmopressin in combination with anticholinergic agents in the treatment of nocturnal enuresis: a systematic review and meta-analysis
Authors: Cai Tong , Yao Yi , Sun Weigui , Lei Peipei 
Published: October 2023

BackgroundThe desmopressin combined with anticholinergic agents for the treatment of nocturnal enuresis (NE) remains controversial. This meta-analysis assesses the efficacy and safety of desmopressin compared with desmopressin plus anticholinergic agents for the treatment of NE.MethodsWe searched MEDLINE, Embase, and Cochrane Controlled Trials Register databases for RCTs published for the treatment of NE. Systematic review was carried out using the Preferred Reporting Items for Systematic Reviews and Meta-analyses. This meta-analysis used RevMan v.5.1.0 to analyze data.ResultsEight studies involving 600 patients (293 in the combination group and 307 in the desmopressin group) contained meaningful data. The results were as follows: after one month of treatment, compared with the desmopressin monotherapy group, the combination group was significantly better in treating NE in FR (full responders, P = 0.003), FR + PR (partial responders) (P &lt; 0.0001), and the mean number of wet nights (P = 0.004); also, the combination group had a better effect in FR (P &lt; 0.00001), FR + PR (P = 0.02) and the mean number of wet nights (P = 0.04) after 3 months' treatment. For side effects, combination therapy does not cause more adverse events in treating NE (P = 0.42).ConclusionsThis study elucidates that desmopressin combined with the anticholinergic agent was demonstrated to be more effective in treating NE than desmopressin monotherapy, and the anticholinergic agent does not increase the risk of adverse events (AEs).
The impact of self-efficacy on the well-being of primary school teachers: a Greek-Cypriot study
Authors: Reppa Glykeria , Mousoulidou Marilena , Tzovla Eirini , Koundourou Christiana , Christodoulou Andri 
Published: October 2023

IntroductionThis research was conducted to examine the extent to which teachers’ self-efficacy affects their well-being following the COVID-19 pandemic. The originality of the research lies in the fact that there are not enough studies that simultaneously examine the relationship between well-being and self-efficacy in primary school teachers in Greece and Cyprus.MethodsA total of 258 primary school teacher participants took part in this study, aged 23–62. The Teachers’ Sense of Efficacy Scale and the PERMA Profiler questionnaire were used to study the relationship between teachers’ well-being and self-efficacy.ResultsResults show that after the COVID-19 pandemic, teachers’ well-being is moderate to high. Moreover, teachers’ self- efficacy is also high and related to their well-being.DiscussionAn important finding from the current research is that teachers’ self-efficacy in promoting student engagement was the most important predictor for teachers’ well-being. The implications of the results are discussed, and recommendations are made.
International Chinese students’ experiences of participating in mandala-based art therapy in Korea: a phenomenological study
Authors: Mo Ya Nan , Ko Kyung Soon 
Published: October 2023

BackgroundAlthough China and South Korea share a similar East Asian culture, owing to major social and cultural differences, international students encounter several difficulties, which can lead to various psychological problems.ObjectiveTo explore the experiences of eight Chinese doctoral students in South Korea participating in mandala-based art therapy.MethodData for this phenomenological study were gathered through individual interviews and visual art from April 5 to 20, 2022. The MAXQDA software program was used for data analysis.ResultsThe data analysis results yielded 355 codes, 53 subcategories, and 17 categories. Five final themes emerged: (a) sealed lips by others’ eyes, (b) inner exploration and outward expression, (c) healing power of the mandala, (d) filling the inner space together, and (e) opportunities to understand art therapy.ConclusionThe researchers hope that completing this intervention will enable participants to complete their studies more effectively and achieve their ideals as well as future career goals, helping them ultimately return home safely with both personal and academic growth.
The impact of the two-year COVID-19 pandemic on hospital admission and readmissions of children and adolescents because of mental health problems
Authors: Raffagnato Alessia , Miscioscia Marina , Bruni Gaia , Del Col Lara , Traverso Annalisa , Ferrarese Martina , Ancora Caterina , Zanato Silvia , Gatta Michela 
Published: October 2023

PurposeThis study aimed to investigate the specific risk factors and psycho-social and clinical features of hospitalized neuropsychiatric patients during the COVID pandemic and to analyze the hospital readmission phenomenon, which, according to recent studies, increased in frequency during the first pandemic period.Patients and methodsThis observational retrospective cohort study examined 375 patients aged between 0 and 17 years who were hospitalized between 1 February 2018 and 31 March 2022 due to neuropsychiatric issues. The majority of the patients were girls: there were 265 girls compared to 110 boys (M = 13.9 years; SD 2.30 years). The total sample was divided into two groups: the pre-COVID-19 group (160 inpatients hospitalized between February 2018 and February 2020) and the COVID-19 group (215 inpatients hospitalized between March 2020 and March 2022). To explore the readmission phenomenon (second aim), we selected from the two groups of patients with at least one hospital readmission within 365 days after the first discharge. Multiple variables (sociodemographic, clinical, psychological, and related to hospitalization) were collected for each patient by reviewing their medical records.ResultsThe risk factors for mental health disorders were similar between the two groups, except for the significantly increased use of electronic devices in the COVID-19 group, increasing from 8.8% in the pre-COVID-19 group to 29.2% in the COVID-19 group. Patients suffering from eating disorders increased from 11.3% in the pre-COVID-19 group to 23.8% in the COVID-19 group. Hospital readmissions nearly increased from 16.7% in the 2-year pre-COVID-19 period to 26.2% in the 2-year COVID-19 period. A total of 75% of patients hospitalized three or more times in the last 2 years and 85.7% of the so-called “revolving door” patients (with relapse within 3 months after discharge) were identified in the COVID-19 group. However, the comparison between the two groups of patients readmitted before and during the COVID-19 pandemic did not show any differences in terms of sociodemographic and clinical characteristics.ConclusionIn conclusion, there was a significant increase in hospital readmissions, but these results suggest the need for better coordination between hospital and territorial services in managing the complexity of mental health problems related to situations arising from the COVID-19 pandemic and the necessity to implement prevention strategies and services.
Trends, influencing factors and prediction analysis of under-five and maternal mortality rates in China from 1991 to 2020
Authors: Zhang Meng , Qu Huimin , Xia Junfen , Hui Xiaoqing , Shi Cannan , Xu Feng , He Junjian , Cao Yuan , Hu Mengcai 
Published: October 2023

IntroductionUnder-five mortality rate (U5MR) and maternal mortality rate (MMR) are important indicators for evaluating the quality of perinatal health and child health services in a country or region, and are research priorities for promoting maternal and infant safety and maternal and child health. This paper aimed to analysis and predict the trends of U5MR and MMR in China, to explore the impact of social health services and economic factors on U5MR and MMR, and to provide a basis for relevant departments to formulate relevant policies and measures.MethodsThe JoinPoint regression model was established to conduct time trend analysis and describe the trend of neonatal mortality rate (NMR), infant mortality rate (IMR), U5MR and MMR in China from 1991 to 2020. The linear mixed effect model was used to assess the fixed effects of maternal health care services and socioeconomic factors on U5MR and MMR were explored, with year as a random effect to minimize the effect of collinearity. Auto regressive integrated moving average models (ARIMA) were built to predict U5MR and MMR from 2021 to 2025.ResultsThe NMR, IMR, U5MR and MMR from 1991 to 2020 in China among national, urban and rural areas showed continuous downward trends. The NMR, IMR, U5MR and MMR were significantly negatively correlated with gross domestic product (GDP), the proportion of the total health expenditure (THE) to GDP, system management rate, prenatal care rate, post-natal visit rate and hospital delivery rate. The predicted values of national U5MR from 2021 to 2025 were 7.3 ‰, 7.2 ‰, 7.1 ‰, 7.1 ‰ and 7.2 ‰ and the predicted values of national MMR were 13.8/100000, 12.1/100000, 10.6/100000, 9.6/100000 and 8.3/100000.ConclusionChina has made great achievements in reducing the U5MR and MMR. It is necessary for achieving the goals of Healthy China 2030 by promoting the equalization of basic public health services and further optimizing the allocation of government health resources. China’s experience in reducing U5MR and MMR can be used as a reference for developing countries to realize the SDGs.
Virtual overdose monitoring services/mobile overdose response services: estimated number of potentially averted drug poisoning fatality events by various telephone and digital-based overdose prevention/harm reduction services in North America
Authors: Rioux William , Enns Benjamin , Ghosh S. Monty 
Published: October 2023

BackgroundVirtual overdose monitoring services or Mobile Overdose Response Services (MORS) are novel virtual harm reduction tools which have gained popularity as an adjunct public health intervention especially for those who cannot access harm reduction resources through traditional means. At this time, relatively little is known about their ability to reach their goals of reducing overdose mortality. Our study aims to summarize the potential effectiveness of various MORS collectively to avoid potential mortality from a drug poisoning event/drug overdose.MethodsUtilizing publicly available data from various MORS alongside some usage data provided by these services for this study, we model the impact of these services on fatal drug poisoning/overdose. In order to calculate the number of deaths averted, a Monte Carlo simulation was used to calculate point estimates with 95% confidence for fatal drug poisonings/drug overdose potentially averted through the utilization of various MORS.ResultsFrom the earliest mention of MORS in current literature (2019), a total of 299 drug poisoning/overdose events occurred across these services. Noting the broad range of mortality statistics available in current literature, these technologies have potentially prevented between 33 to 243 deaths. Our Monte Carlo estimates 135 potentially fatal drug poisonings/overdose were overall averted by the various MORS.ConclusionsWhile there is yet to be a robust data set proving the effectiveness of these services, conservative estimates show that MORS can reduce mortality associated with substance use and therefore should be considered as a viable harm-reduction strategy but as an adjunct to more established harm reduction services such as supervised consumption sites and supervised injection facilities. While more research is needed, clinicians and practitioners should consider the suggestion of these tools for patients who use drugs.
Unplanned urbanization and health risks of Dhaka City in Bangladesh: uncovering the associations between urban environment and public health
Authors: Rahaman Mohammad Anisur , Kalam Abul , Al-Mamun Md. 
Published: October 2023

BackgroundDhaka City, the capital of Bangladesh, has experienced rapid and unplanned urbanization over the past few decades. This process has brought significant challenges to public health as the urban environment has become a breeding ground for various health risks. Understanding the associations between unplanned urbanization, the urban environment, and public health in Dhaka City is crucial for developing effective interventions and policies.ObjectivesThis review paper aims to uncover the associations between unplanned urbanization and health risks in Dhaka City, with a specific focus on the urban environment and its impact on public health. The objectives of this study are to examine the health challenges faced by the city’s population, explore the specific urban environmental factors contributing to health risks, analyze the socioeconomic determinants of health in unplanned urban areas, evaluate existing policies and governance structures, identify research and data gaps, and provide recommendations for future interventions.MethodsA comprehensive literature review was conducted to gather relevant studies, articles, reports, and policy documents related to unplanned urbanization, the urban environment, and public health in Dhaka City. Various databases and online resources were searched, and the selected literature was critically analyzed to extract key findings and insights.ResultsThe findings reveal that unplanned urbanization in Dhaka City has led to a range of public health risks, including air pollution, inadequate water and sanitation, poor waste management, overcrowding, slums, and substandard housing conditions. These environmental factors are strongly associated with respiratory diseases, waterborne illnesses, and other adverse health outcomes. Socioeconomic determinants such as poverty, income inequality, and limited access to healthcare further exacerbate the health risks faced by the urban population.ConclusionUnplanned urbanization in Dhaka City has significant implications for public health. Addressing the associations between unplanned urbanization, the urban environment, and public health requires comprehensive policies and interventions. Improved urban planning, enhanced infrastructure, and better policy governance are essential for mitigating health risks. Furthermore, addressing socioeconomic disparities and ensuring equitable access to healthcare services are crucial components of effective interventions.
Timing of outdoor light exposure is associated with sleep-wake consolidation in community-dwelling older men
Authors: Lok Renske , Ancoli-Israel Sonia , Ensrud Kristine E. , Redline Susan , Stone Katie L. , Zeitzer Jamie M. 
Published: October 2023

IntroductionA consolidated sleep-wake pattern is essential for maintaining healthy cognition in older individuals, but many suffer from sleep fragmentation that exacerbates age-related cognitive decline and worsens overall mental and physical health. Timed light exposure (light therapy) has been explored as a countermeasure, but mixed results have been obtained. To determine whether the timing of light exposure is important for sleep-wake consolidation, we analyzed the natural light diets of a cohort of community-dwelling older men.MethodsThe degree of sleep-wake fragmentation and light exposure patterns were obtained over a week using wrist actigraphy. Correlations between fragmentation, light patterns, and various physical and mental health measures were examined (n = 877).ResultsOur findings revealed that higher sleep-wake fragmentation correlated with poorer physical and mental health and reduced cognition. Moreover, reduced daytime light exposure was associated with increased sleep-wake fragmentation. Interestingly, morning and evening light exposure (&gt;1,000 lux) were not useful in distinguishing between low and high sleep-wake fragmentation scores, while increased afternoon light exposure showed much better discrimination. Specifically, optimal discrimination between low and high fragmentation occurred 6.7 h after habitual sleep offset. This suggests that afternoon light therapy might be more efficient in consolidating sleep and wake in older adults, particularly in those with low-amplitude circadian rhythms.DiscussionThis study highlights the significance of properly-timed light exposure in promoting consolidated sleep and cognitive health among older individuals. Tailored light-based strategies may have the potential to enhance physical, mental, and cognitive well-being in the aging population.
Intravascular Hemolysis and AKI in Children Undergoing Extracorporeal Membrane Oxygenation
Authors: Strong Amy E. , Zee Jarcy , Fulchiero Rosanna , Kilbaugh Todd J. , Connelly James , Makeneni Spandana , Campos Diego , Laskin Benjamin L. , Denburg Michelle R. 
Published: October 2023

Key Points

The incidence of AKI while undergoing ECMO in pediatric patients is high and independently increases mortality.Laboratory markers consistent with intravascular hemolysis increase the hazard of a composite outcome of AKI or RRT while undergoing ECMO.Further research into appropriate monitoring or treatment of ECMO-associated hemolysis may lead to important interventions to prevent AKI.

Background
AKI is common in patients requiring extracorporeal membrane oxygenation (ECMO), with a variety of proposed mechanisms. We sought to describe the effect of laboratory evidence of ECMO-associated intravascular hemolysis on AKI and RRT.

Methods
This retrospective cohort study included patients treated with ECMO at a single center over 10 years. The primary outcome was a composite of time to RRT or AKI (by creatinine-based Kidney Disease Improving Global Outcomes criteria) after ECMO start. Serum creatinine closest to ECMO start time was considered the pre-ECMO baseline and used to determine abnormal kidney function at ECMO start. The patient's subsequent creatinine values were used to identify AKI on ECMO. Multivariable cause-specific Cox proportional hazards models were used to assess the effect of separate markers of intravascular hemolysis on the time to the composite outcome after controlling for confounders.

Results
Five hundred and one children were evaluated with a median age 1.2 years, 56% male. Four separate multivariable models, each with a different marker of hemolysis (plasma-free hemoglobin, lactate dehydrogenase (LDH), minimum platelet count, and minimum daily hemoglobin), were used to examine the effect on the composite outcome of AKI/RRT. An elevated plasma-free hemoglobin, the most specific of these hemolysis markers, demonstrated an almost three-fold higher adjusted hazard for the composite outcome (hazard ratio [HR], 2.9; P value < 0.01; 95% confidence interval [CI], 1.4 to 5.6). Elevated LDH was associated with an adjusted HR of 3.1 (P value < 0.01; 95% CI, 1.7 to 5.5). Effect estimates were also pronounced in a composite outcome of only more severe AKI, stage 2+ AKI/RRT: HR 6.6 (P value < 0.01; 95% CI, 3.3 to 13.2) for plasma-free hemoglobin and 2.8 (P value < 0.01; 95% CI, 1.5 to 5.6) for LDH.

Conclusions
Laboratory findings consistent with intravascular hemolysis on ECMO were independently associated with a higher hazard of a composite outcome of AKI/RRT in children undergoing ECMO.