bluuebunny/crossref_metadata_2025_split huggingface dataset:
Selective neurodegeneration in murine mucopolysaccharidosis VII is progressive and reversible
Authors: Heuer Gregory G. , Passini Marco A. , Jiang Kanli , Parente Michael K. , Lee Virginia M.‐Y. , Trojanowski John Q. , Wolfe John H. 
Published: December 2002

AbstractThe mucopolysaccharidoses are caused by inherited deficiencies of lysosomal enzymes involved in the degradative pathway of glycosaminoglycans. Lysosomal storage leads to cellular and organ dysfunction, including mental retardation. Storage lesions are found throughout the diseased brain, but little is known about the cellular and molecular mechanisms that underlie brain dysfunction. In the mouse model of mucopolysaccharidosis VII, we found that specific regions of the brain are vulnerable to neurodegeneration, characterized by the presence of ubiquitin inclusions, neurofilament inclusions, and reactive astrogliosis. The pathological lesions were found predominantly in the hippocampus and cerebral cortex, and they increased progressively with age. Treatment with a recombinant viral vector to correct the enzymatic defect quantitatively reversed the neurodegenerative lesions in targeted regions to normal levels.
Diet and Parkinson's disease: A potential role of dairy products in men
Authors: Chen Honglei , Zhang Shumin M. , Hernán Miguel A. , Willett Walter C. , Ascherio Alberto 
Published: December 2002

AbstractDiet may play a causative role in Parkinson's disease (PD), but potential associations between diet and PD risk rarely have been assessed in prospective studies. We investigated associations between food intakes and PD risk in two large prospective cohorts in which 210 incident PD cases in men and 184 in women were documented. A positive association was found between dairy intake and PD risk in men (relative risk [RR] comparing extreme categories, 1.8; p trend = 0.004), but not in women (RR, 1.1; p trend = 0.9). No other food groups were associated with PD risk in either men or women. Further analyses among men showed significant positive associations with PD risk for intakes of several dairy foods as well as dairy calcium (RR, 1.5; p trend = 0.02), dairy vitamin D (RR, 1.6; p trend = 0.004), dairy protein (RR, 1.6; p trend = 0.01), and lactose (RR, 1.8; p trend = 0.002), but not dairy fat (RR, 1.1; p trend = 0.4). Intakes of calcium, vitamin D, and protein from other dietary or supplemental sources were not related to PD risk in men. Our results suggest that higher intake of dairy products may increase the risk of PD in men; however, this finding needs further evaluation, and the underlying active components need to be identified.
Congenital hypomyelinating neuropathy, central dysmyelination, and Waardenburg–Hirschsprung disease: Phenotypes linked by SOX10 mutation
Authors: Inoue Ken , Shilo Konstantin , Boerkoel Cornelius F. , Crowe Carol , Sawady Joram , Lupski James R. , Agamanolis Dimitri P. 
Published: December 2002

AbstractA unique phenotype of Waardenburg–Hirschsprung disease (WS4) accompanied by peripheral neuropathy and central dysmyelination has been recognized recently in association with SOX10 mutations. We report an infant boy with lethal congenital hypomyelinating neuropathy and WS4 who had a heterozygous SOX10 mutation (Q250X). Histopathological studies showed an absence of peripheral nerve myelin despite normal numbers of Schwann cells and profound dysmyelination in the central nervous system. These observations suggest that some SOX10 mutations such as Q250X may allow Schwann cells and oligodendrocytes to proliferate but interfere with further differentiation to form myelin. In contrast with the SOX10 loss‐of‐function mutations causing only WS4, mutations associated with both peripheral and central dysmyelination may affect pathology through a dominant‐negative mechanism.
Association of chromosome 10 losses and negative prognosis in oligoastrocytomas
Authors: Bissola Lorena , Eoli Marica , Pollo Bianca , Merciai Bianca Maria , Silvani Antonio , Salsano Ettore , Maccagnano Carmelo , Bruzzone Maria Grazia , Fuhrman Conti Anna Maria , Solero Carlo Lazzaro , Giombini Sergio , Broggi Giovanni , Boiardi Amerigo , Finocchiaro Gaetano 
Published: December 2002

AbstractOligoastrocytomas are mixed gliomas harboring different genetic alterations and with heterogeneous clinical evolution. We have looked for correlations between genetic losses and clinical evolution in 34 oligoastrocytomas. Loss of heterozygosity (LOH) with different microsatellite markers was studied on chromosomes 1p, 10q, 17p, and 19q. LOH on 1p was found in 44% of the tumors, on 10q in 24%, on 17p in 18%, and on 19q in 38%. LOH on 1p and 19q was combined in 29% of the patients. LOH on 1p was associated with significantly longer overall survival (p = 0.0092) and LOH on 10q with shorter overall survival (p = 0.0206). The observation that LOH on 10q predicts a short survival in oligoastrocytomas is novel and provides further evidence that genetic analysis may help to predict the clinical evolution of different gliomas, giving a more rationale basis to therapeutic options.
Structural layout of the suburbs of Roman Butrint, southern Albania: results from a gradiometer and resistivity survey
Authors: Hounslow Mark W. , Chroston P. Neil 
Published: December 2002

AbstractButrint, a World Heritage Site in southern Albania, encompasses 3000 years of Mediterranean history from the Hellenistic Greeks to the Venetians. In Roman times a suburb of Butrint spread out across the marsh plain to the south of the city, where approximately 20 ha have been surveyed with a fluxgate gradiometer, and 4 ha with a ground resistivity meter. The magnetic anomalies show that the line of the aqueduct into the centre of Butrint is evident for part of this area, but the aqueduct signature becomes progressively less distinct on approaching the Vivari Channel, probably owing to deeper burial. A complex of confused, short‐wavelength anomalies, but with some linear elements covers about 3 ha and is associated with exposed building remains. The abrupt termination of these anomalies to the west may be associated with the former Roman water front. Isolated smaller areas of magnetic anomalies up to 0.5 ha in the area surveyed, show buildings and associated ditches away from the main complex. The resistivity survey allows some detailed constraints on the position of buildings in the densely occupied area. Analysis of the orientation of linear anomalies indicates there are two co‐genetic sets of magnetic and resistivity linear anomalies. A strong NW–SE and weaker NE–SW set, which parallel the aqueduct and the alignment of standing walls. This set appears to indicate a regular building alignment across the whole site, which is reflected in the orientation of the few current standing walls on the site. This set may post‐date the building of the aqueduct, because these reflect the latest standing remains on the site. A second stronger set of E–W and (subsidiary) N–S linear anomalies may signify either an early system of streets, or perhaps an agricultural‐based ditch system developed prior to the buildings on the site. This second set may pre‐date the building of the aqueduct in the first century BC, when Butrint became a Roman colony. An alternative interpretation suggests part of the suburbs street plan may be based on a non‐conventional triangular network of roadways, the design of which may have been emulated in the construction of the medieval Triangular Castle. Copyright © 2002 John Wiley & Sons, Ltd.
Meaningful patterns of activity amongst the long‐term inner city unemployed: a qualitative study
Authors: Ball Myfanwy , Orford Jim 
Published: December 2002

AbstractA number of studies have sought to establish the social psychological factors involved in the maintenance of active lifestyles during long‐term unemployment. The aim of this study was to describe and account for the development and maintenance of different patterns of activity, with reference to their perceived meaningfulness. This was undertaken with a sample of Birmingham's inner city, long‐term unemployed population recruited from three inner city Jobcentres, including men and women, and White, Asian and African Caribbean participants (N = 24). Interviews were conducted using a semi‐structured interview guide. Using the qualitative software program, NUD.IST, the data were analysed according to the principles of the grounded theory approach. Activities were characterized as: domestic; educational; work‐like; socializing; and none. A model of meaningful activity in the context of formal unemployment was developed. The main components of the model were: features of formal employment that inhibited participants' engagement in it; the requirements for personal meaningful activity (challenging activity, effort and commitment, and being valued by others); the consequences of meaningful activity (opportunities for self‐determination and self‐development, and achievement, competence, and confidence) and consolidating factors (social comparison, self‐appraisal, religious and political beliefs, and social support). Theories of unemployment of Jahoda, Warr, and Fryer are considered in the light of the present findings. Copyright © 2002 John Wiley & Sons, Ltd.
Self‐esteem, stigma and community participation amongst people with learning difficulties living in the community
Authors: Abraham Charles , Gregory Nicky , Wolf Lisa , Pemberton Richard 
Published: December 2002

AbstractA cross‐sectional study examined the relationship between self‐esteem, community participation, age, perceived stigma and social support amongst a sample of 50 people with mild to moderate learning difficulties attending two day centres. Respondent‐paced, structured interviews following ethical and assessment guidelines were used to gather data. Retest interviews were conducted with 20% of the sample 3 months subsequently and only those measures with good test–retest reliability were used to test hypotheses. The results showed fairly high levels of community participation and self‐esteem. Self‐esteem was negatively correlated with stigma and a sub‐group with high concerns regarding meeting strangers was identified. In accordance with studies of non‐disabled samples, self‐esteem was positively associated with age. Social support was comparable to, or higher than, that observed in non‐disabled samples. High social support was observed for staff going out with respondents and for practical help from liked persons and friends. Community participation appeared to be related to higher self‐esteem in older participants but lower self‐esteem in younger participants. Implications for future research and practice are discussed. Copyright © 2002 John Wiley & Sons, Ltd.
Systematic use of a collagen‐based vascular closure device immediately after cardiac catheterization procedures in 1,317 consecutive patients
Authors: Eggebrecht Holger , Haude Michael , Woertgen Uta , Schmermund Axel , Birgelen Clemens von , Naber Christoph , Baumgart Dietrich , Kaiser Christoph , Oldenburg Olaf , Bartel Thomas , Kroeger Knut , Erbel Raimund 
Published: December 2002

AbstractDespite recent advances in interventional cardiology, vascular access complications continue to be a significant problem. Conventional manual compression of the femoral access site is associated with prolonged immobilization and significant patient discomfort. We investigated the performance of a collagen‐based closure device applied immediately after catheterization and its complication rate in 1,317 consecutive patients undergoing cardiac catheterization or coronary angioplasty. Patients undergoing coronary angioplasty (n = 644) received more heparin than patients with diagnostic cardiac catheterization (n = 673; 9,675 ± 1,144 IU vs. 6,419 ± 2,211 IU; P < 0.0001). Deployment success rates of the closure device were comparable for patients undergoing diagnostic vs. interventional procedures (95.8% vs. 96.7%; P = 0.46). Complete hemostasis immediately after deployment of the device was achieved in > 90% of all patients, but was lower in the interventional group (93.7% vs. 90.6%; P = 0.05). Major complications including any vascular surgery, major bleeding requiring transfusion, retroperitoneal hematoma, thrombosis or loss of distal pulses, groin infections, significant groin hematoma, and death were observed in 0.53% of all patients, with no differences between diagnostic or interventional patients (0.62% vs. 0.45%; P = 0.953). Subgroup analysis revealed female gender as a predictor of access site complications. Systematic sealing of femoral access sites after both diagnostic and interventional procedures allows for immediate sheath removal with reliable hemostasis. The use of a collagen‐based closure device is associated with a low rate of clinically significant complications. Cathet Cardiovasc Intervent 2002;57:486–495. © 2002 Wiley‐Liss, Inc.
Percutaneous cardiopulmonary support in critical patients needing coronary interventions with stents
Authors: Suárez de Lezo José , Pan Manuel , Medina Alfonso , Pavlovic Djordje , Romero Miguel , Segura José , Ruiz Martin , Ojeda Soledad , Muñoz Juan , Rodriguez Marcos 
Published: December 2002

AbstractPercutaneous cardiopulmonary support (CPS) has proven to be a technique of value in high‐risk coronary patients undergoing percutaneous balloon angioplasty. Since May 1994, we have combined the use of CPS and coronary stent revascularization in 92 patients. In 68 of them, the CPS was used as a prophylactic procedure (group 1); in the remaining 24, the CPS was used as an emergency procedure to stabilize and even resuscitate patients with acute myocardial infarction and circulatory collapse, in order to attempt urgent percutaneous coronary stent treatment (group 2). Primary success was achieved in 66 patients from group 1 (97%). One patient died and another had a myocardial infarction. After 28 ± 19 months of follow‐up, 20 patients (30%) from group 1 had a major adverse cardiac event. The remaining 46 patients (68%) are alive, with persistent clinical benefit. In group 2, reperfusion and stent treatment was always achieved. However, 14 patients had an in‐hospital death. Five patients from group 2 had a major adverse event at follow‐up (47 ± 20 months). Nine patients (38%) remain at present in functional class I–II. Percutaneous CPS provides safe conditions to accomplish stent coronary revascularization in high‐risk patients and those with acute myocardial infarction and failing heart. Long‐term follow‐up of survivors shows persistent benefit in most patients. Cathet Cardiovasc Intervent 2002;57:467–475. © 2002 Wiley‐Liss, Inc.
Effect of antioxidant probucol for preventing stent restenosis
Authors: Kim Moo Hyun , Cha Kwang Soo , Han Jin‐Yeong , Kim Hye Jin , Kim Jong Seong 
Published: December 2002

AbstractProbucol is a lipid‐lowering drug that has an antioxidant effect. The authors sought to investigate the effect of probucol on stent restenosis after the usual 3‐day pretreatment protocol. From March 1999 to August 2000, 78 patients (mean age, 56 ± 8; 49 male) with coronary artery disease who underwent coronary stenting were enrolled. After a diagnostic angiography was done, each eligible patient was randomized to either the probucol or the control group. Following the procedure, ticlopidine was administered for 1 month; aspirin and probucol continuously. Angiographic follow‐up was done in 81% (57/70) and angiographic restenosis was not different between the two groups (21% vs. 24%; P = 0.81). In conclusion, antioxidant probucol did not show a beneficial effect on stent restenosis with 3 days of premedication protocol. Cathet Cardiovasc Intervent 2002;57:424–428. © 2002 Wiley‐Liss, Inc.
Platelet glycoprotein IIb/IIIa inhibition using eptifibatide with primary coronary stenting for acute myocardial infarction: A 30‐day follow‐up study
Authors: Kaul Upendra , Gupta Ripen K. , Haridas Kottaram K. , Ramesh Saligrama S. , Sethi Kamal K. , Singh Balbir , Agarwal Rajiv , Yadave Ram D. , Ghose Tapan , Sapra Rakesh R. , Bajaj Rajiv , Shahi Madhukar , Bhagwat Ajit , Kumar Pramod , Mathews Omen P. , Soni Pratik K. 
Published: December 2002

AbstractThe results of primary coronary stenting for acute myocardial infarction (AMI) have been reported to improve significantly with the concomitant administration of platelet glycoprotein IIb/IIIa inhibitor abciximab. There are, however, no data available with the use of eptifibatide, a more cost‐effective, small‐molecule GP IIb/IIIa blocker with a shorter half‐life. In a prospective multicenter feasibility and efficacy study, we assigned 55 consecutive patients with AMI being taken up for primary stenting to receive eptifibatide just before the procedure (two boluses of 180 μg/kg 10 min apart and a 24‐hr infusion of 2 μg/kg/min). Clinical outcomes were evaluated at 30 days after the procedure. The angiographic patency of the vessel with TIMI flow rates, TIMI myocardial perfusion (TMP) grade, and corrected TIMI frame counts were assessed at the end of procedure and before hospital discharge. At 30 days, the primary endpoint, a composite of death, myocardial infarction, and urgent target vessel revascularization (TVR) was seen in 12.7% of patients. The TIMI 3 and TMP grade 3 flow, which was seen in 93% and 86% of patient, respectively, at the end of the procedure, declined to 86% and 78%, respectively (P < 0.05) before hospital discharge. Corrected TIMI frame counts also decreased from 25.7 ± 7.2 to 22.9 ± 6.8 (P < 0.05). There were five (9.1%) instances of subacute thrombosis (SAT) presenting as AMI, needing urgent TVR in all, within 3–5 days of the primary procedure. No excessive bleeding complication, directly attributable to the use of eptifibatide, was observed. The study was terminated prematurely because of an unacceptable SAT rate. Administration of eptifibatide along with primary stenting for AMI is associated with a high TIMI 3 and TMP grade 3 flow acutely. However, these flows decline significantly before hospital discharge and lead to a high rate of SAT. The dosage and duration of infusion of eptifibatide in this setting needs further evaluation. Cathet Cardiovasc Intervent 2002;57:497–503. © 2002 Wiley‐Liss, Inc.
Suture‐mediated closure of antegrade femoral arteriotomy following infrainguinal intervention
Authors: Khosla Sandeep , Kunjummen Binu , Guerrero Mayra , Manda Ravi , Razminia Mansoor , Ahmed Aziz 
Published: December 2002

AbstractAntegrade femoral arterial access has been less commonly adopted for infrainguinal intervention due to increased risk of retroperitoneal hemorrhage secondary to noncompressibility of arteriotomy site. We evaluated the efficacy and safety of suture‐mediated closure of antegrade femoral arteriotomy using the Closer device. Twelve consecutive patients undergoing infrainguinal intervention (females, 5; mean body weight, 69 ± 16 kg; limb threatening ischemia, 50%) underwent repair of the antegrade femoral arteriotomy immediately postprocedure using the Closer. Indications for antegrade access were excessive iliac tortuosity (6/12), long femoral artery occlusion (5/12), and bilateral aortoiliac bifurcation stents (1/12). The acute procedural success (immediate hemostasis without need for manual compression) was 100%. The mean time to ambulation was 3.9 ± 1.5 hr and the procedure‐related length of stay was 18 ± 5.5 hr. In conclusion, repair of antegrade arterial puncture is safe and effective following infrainguinal intervention. Cathet Cardiovasc Intervent 2002;57:504–507. © 2002 Wiley‐Liss, Inc.
Long balloon angioplasty with focal stenting for the treatment of diffuse coronary artery disease
Authors: Prieto Alejandro R. , Przybysz Aaron , Fischell Tim A. 
Published: December 2002

AbstractThe objective of this study was to evaluate the efficacy of treating long coronary lesions (> 30 mm) with either a 40 or a 60 mm long Scimed Cobra balloon followed by focal (contingency) stenting of areas with suboptimal results. Diffuse lesion length is a morphological characteristic associated with a poorer clinical outcome after balloon angioplasty with or without stenting. Patients were enrolled in a prospective randomized fashion to have initial PTCA with either a 40 or a 60 mm long balloon followed by focal stenting in areas with suboptimal results. The MACE rate at 6‐month follow‐up was collected from all patients and was the primary endpoint of the study. A total of 41 patients were enrolled into the study. The acute procedural success rate was 97.5% with a 6‐month MACE rate of 9.8%. The use of long balloons with contingency stenting is a highly effective strategy for the treatment of diffuse coronary lesions. Cathet Cardiovasc Intervent 2002;57:437–443. © 2002 Wiley‐Liss, Inc.
Comparative study of aging in the mouse olfactory bulb
Authors: Mirich Jennifer M. , Williams Nathaniel C. , Berlau Daniel J. , Brunjes Peter C. 
Published: December 2002

AbstractGene knockout technologies have been used to elevate the mouse as a model species. However, little work has examined age and strain differences in the mouse olfactory system. The present study compared the olfactory bulbs of mature (6 month) and aged (24 month) males of BALB/cBy, C57BL/6J, and DBA/2 strains. Volumes of the glomerular (GLM), external plexiform (EPL), and mitral/granule cell (MIG) layers varied little from strain to strain. Volume measurements increased with age even when corrected for body weight differences. Two nonoverlapping interneuron populations were examined with immunohistochemistry. Staining for the calcium binding protein calretinin varied little between strains, but age‐related increases in staining were seen in EPL of C57BL/6J mice. Typical patterns of tyrosine hydroxylase immunoreactivity were observed in all subjects except for old DBA/2 mice, which evidenced considerable staining in submitral areas. Age‐related increases were observed in BALB/cBy and DBA/2 mice but not in the C57BL/6J strain. Glial fibrillary acidic protein staining was similar in old BALB/cBy and DBA/2 mice, with astrocytes in all layers of the bulb, but more concentrated in the MIG. However, C57BL/6J tissue revealed very large astrocytes relatively evenly distributed in all layers. Cell proliferation dropped dramatically with age. Labeled cells could still be observed along the lateral ventricles, but very few were observed within the rostral migratory stream or subventricular zone. Although TUNEL labeling revealed many apoptotic figures in the granule cell layer of young subjects, almost no staining was seen in aged mice. J. Comp. Neurol. 454:361–372, 2002. © 2002 Wiley‐Liss, Inc.