bluuebunny/crossref_metadata_2025_split huggingface dataset:
Association between Helicobacter pylori infection and incident risk of dementia: The AMI cohort
Authors: Hernández‐Ruiz Virgilio , Roubaud‐Baudron Claire , Von Campe Hugo , Retuerto Noelia , Mégraud Francis , Helmer Catherine , Amieva Hélène , Pérès Karine 
Published: January 2024

AbstractBackgroundChronic infectious diseases are increasingly being considered as potential contributors to dementia risk. Among those infections, Helicobacter pylori, the main cause of chronic gastritis worldwide, has been suggested. As the prevalence of H. pylori infection has decreased, the main objective of this work was to reconsider the association between H. pylori infection and the risk of incident dementia, including Alzheimer's disease.MethodsProspective cohort of 689 older (≥65 years) agricultural workers from Southwest France. Descriptive and comparative analyses were performed according to H. pylori status determined by serology at baseline. The risk of incident dementia according to H. pylori status over a 7‐year follow‐up was explored by survival analyses: Kaplan–Meier curve and Cox proportional hazards models.ResultsTwo‐hundred (29.0%) participants were H. pylori‐positive at baseline. Compared to H. pylori‐negative participants, they showed worse cognitive performances at baseline. Eighty‐five incident dementia cases were diagnosed during the follow‐up period. After adjustment for age, sex, education, apolipoprotein ε4, and several cardiovascular risk factors, H. pylori remained associated with an increased risk of dementia (HR 1.70, 95% CI, 1.05–2.74). The risk was stronger for Alzheimer's disease (HR 2.85, 95% CI, 1.58–5.12).ConclusionsDespite an observed decrease in H. pylori infection prevalence, this study provides evidence for the association between H. pylori infection and dementia. These results should encourage further research on the mechanisms underlying the contribution of infectious diseases to pathological brain aging, especially the influence of gut inflammation on the brain.
Factors associated with non‐urgent presentations in the paediatric emergency department using Andersen's behavioural model: A cross‐sectional descriptive study
Authors: Montoro‐Pérez Néstor , Montejano‐Lozoya Raimunda , Escribano Silvia , Richart‐Martínez Miguel 
Published: January 2024

AbstractObjectivesTo explore the rate of NUPs and associated factors in the PED of the ‘Hospital Universitario y Politécnico La Fe’ in Valencia (Spain) using Andersen's Behavioural Model.MethodsWe conducted a descriptive cross‐sectional study using Andersen's Behavioural Model in parents visiting the PED with their children at the ‘Hospital Universitario y Politécnico La Fe’ in Valencia (Spain).ResultsThe study involved a total of 530 participants, of whom 419 (79%) had made an NUP. The predisposing factors identified were: (I) paediatric patients brought in by their fathers (OR = 0.460; p = 0.005), (II) lower educational attainment (OR = 3.841; p = 0.000), (III) first‐time parenthood (OR = 2.335; p = 0.000) and (IV) higher parental stress (OR = 1.974; p = 0.023). The enabling factors included: (I) responsibility for a significant part of the childcare shared with others (OR = 0.348; p = 0.041) and (II) the perception that PEDs provide better care than primary care (PC) services (OR = 1.628; p = 0.005). The need factors were: (I) existing chronic illness in the child seeking care (OR = 0.343; p = 0.000) and (II) the perceived severity of the urgency (OR = 0.440; p = 0.031).ConclusionsThe NUP rates found in this study are similar to those found internationally. In accordance with Andersen's Behavioural Model, we identify predisposing, enabling and need factors to explain the multifactorial nature of NUPs in PEDs.Implications for PracticeIdentifying the factors associated with NUPs enables interventions to be targeted at those groups most likely to engage in NUPs, thereby optimising the functioning of the PED and improving the well‐being of children and families. These interventions should focus on improving parental health literacy, providing education on making appropriate decisions about accessing health services and recognising severe symptoms in children, as well as improving access to high‐quality PC services. Providing support to parents during the transition to parenthood would also be beneficial.Reporting MethodThis paper adheres to the STROBE initiative guidelines.Contribution from patients or members of the publicParticipants, who voluntarily agreed to take part, contributed to the study by completing a paper‐based questionnaire containing all the study variables as prepared by the research team.
A phase I/II study evaluating the pharmacokinetics, pharmacodynamics, and safety of drospirenone as an oral contraceptive in Japanese women
Authors: Kitamura Kunio , Colli Enrico , Azuma Rieko , Kikuyama Ryoko , Kanai Masayuki 
Published: January 2024

AbstractAimDrospirenone (DRSP) is a synthetic progestogen approved as a progestin‐only pill for contraception in both the United States and Europe. Herein, we conducted a phase I/II study to evaluate the pharmacokinetics, pharmacodynamics, and safety of DRSP in Japanese women.MethodsSingle and multiple doses of 4 mg of DRSP were orally administered to healthy premenopausal Japanese women. In the multiple‐dose period, 4 mg of DRSP was administered once daily for 24 days. Pharmacokinetics, hormone levels, and adverse events (AEs) were investigated.ResultsTwelve Japanese women participated in this study. The single‐ and multiple‐dose pharmacokinetics of DRSP was similar to that reported in previous studies in Caucasians. In the multiple‐dose period, no subject displayed a progesterone level of more than 5.03 ng/mL. AEs were observed in 11 (91.7%) subjects. The most common AE was genital hemorrhage, which was observed in six (50.0%) subjects, followed by diarrhea and acne in four (33.3%) subjects each. All AEs resolved or improved at the end of the study, and complete recovery was confirmed in all subjects at follow‐up.ConclusionsThe pharmacokinetics of DRSP in Japanese women was similar to that of previous studies performed in Caucasian women. Repeated administration of DRSP maintained low plasma progesterone levels indicating effective inhibition of ovulation. No notable safety concerns were observed. In this phase I/II study, DRSP had no obvious pharmacokinetic, pharmacodynamic, or safety issues to consider in Japanese women.
Emotional Expression between CEO and Chairperson as a Micro‐Foundation of Organizational Capabilities: An Exploratory Mixed Methods Study
Authors: Stephens John Paul , Srour Yossef , Carmeli Abraham 
Published: January 2024

AbstractThe work relationships between CEOs and Chairpersons are key to the functioning of the firm. This study uses survey and interview data to explore how these work relationships serve as a micro‐foundation for an organization's communication climate. Survey data suggested that CEO‐Chairperson relationships can be characterized by emotional carrying capacity (ECC; constructively expressing more positive and negative emotions). The survey‐based model further demonstrated that CEOs and Chairpersons perceive their ECC to positively predict organizational communication climate and, in turn, knowledge creation capabilities. The latter, in turn, are positively associated with firm performance. CEO‐Chairperson dyadic interview data supplemented the associations identified in our survey model. Interviewees identified specific mechanisms behind the associations in the survey model, such as the strategic sharing of positive and negative emotions. Our mixed‐methods approach provides initial evidence for the importance of emotional expression and management as micro‐relational foundations that underpin firm‐level capabilities and performance.
Comparative study of feeding and rumination behaviour of goats and sheep fed mixed grass hay of different chop length
Authors: Krone Birthe , Hummel Jürgen , Riek Alexander , Clauss Marcus , Hünerberg Martin 
Published: January 2024

AbstractRumination is reported to be more pronounced in sheep compared to goats. This study compared the feeding and rumination behaviour of small ruminants and consisted of two experiments (E1 and E2). In E1, four sheep and four goats were offered low‐quality hay (NDFom: 692 g/kg dry matter [DM]), processed to two chop lengths (long hay [LH]: 35 mm; short hay [SH]: 7 mm) in a 2 × 2 factorial (2 species × 2 chop lengths), cross‐over design. In E2, the same animals were offered moderate‐quality hay (NDFom: 636 g/kg DM) processed as LH and SH. Hay was offered for ad libitum consumption. Feeding and rumination behaviour was evaluated using video recordings. Aspects of rumination like chewing frequency were evaluated for 30 min per day. Faecal samples were analysed for faecal‐N and particle size. There was no species effect on feed intake and organic matter digestibility (faecal N as proxy); however, goats consumed more LH than SH in E1 and E2. There was an effect of species on rumination:eating duration (R:E) ratio (higher in sheep) in E1 but not in E2, where there was a tendency for a species effect on rumination duration. In E1 and E2, sheep had a higher R:E ratio for SH than for LH. For rumination behaviour, there was a species effect for number of daily boli, chewing frequency and chews per day (more in sheep) in E1 and E2. No effect of species was found for faecal particle size. Despite much concordance, feed comminution behaviour differed in some aspects between sheep and goats. In an evolutionary context, a shift of significance of rumination could be triggered by a higher amount of abrasives in natural diets of sheep, rendering a shift of chewing towards ruminally prewashed material a rewarding strategy.
Diel metabolic patterns revealed by in situ transcriptome and proteome in a vertically migratory copepod
Authors: Maas Amy E. , Timmins‐Schiffman Emma , Tarrant Ann M. , Nunn Brook L. , Park Jea , Blanco‐Bercial Leocadio 
Published: January 2024

AbstractZooplankton undergo a diel vertical migration (DVM) which exposes them to gradients of light, temperature, oxygen, and food availability on a predictable daily schedule. Disentangling the co‐varying and potentially synergistic interactions on metabolic rates has proven difficult, despite the importance of this migration for the delivery of metabolic waste products to the distinctly different daytime (deep) and nighttime (surface) habitats. This study examines the transcriptomic and proteomic profiles of the circumglobal migratory copepod, Pleuromamma xiphias, over the diel cycle. The transcriptome showed that 96% of differentially expressed genes were upregulated during the middle of the day – the period often considered to be of lowest zooplankton activity. The changes in protein abundance were more spread out over time, peaking (42% of comparisons) in the early evening. Between 9:00 and 15:00, both the transcriptome and proteome datasets showed increased expression related to chitin synthesis and degradation. Additionally, at 09:00 and 22:00, there were increases in myosin and vitellogenin proteins, potentially linked to the stress of migration and/or reproductive investment. Based on protein abundances detected, there is an inferred switch in broad metabolic processes, shifting from electron transport system in the day to glycolysis and glycogen mobilization in the afternoon/evening. These observations provide evidence of the diel impact of DVM on transcriptomic and proteomic pathways that likely influence metabolic processes and subsequent excretion products, and clarify how this behaviour results in the direct rapid transport of waste metabolites from the surface to the deep ocean.
MYC2 regulates stomatal density and water use efficiency via targeting EPF2/EPFL4/EPFL9 in poplar
Authors: Xia Yufei , Jiang Shenxiu , Wu Wenqi , Du Kang , Kang Xiangyang 
Published: January 2024

Summary

Although polyploid plants have lower stomatal density than their diploid counterparts, the molecular mechanisms underlying this difference remain elusive.

Here, we constructed a network based on the triploid poplar transcriptome data and triple‐gene mutual interaction algorithm and found that PpnMYC2 was related to stomatal development‐related genes PpnEPF2, PpnEPFL4, and PpnEPFL9. The interactions between PpnMYC2 and PagJAZs were experimentally validated. PpnMYC2‐overexpressing poplar and Arabidopsis thaliana had reduced stomatal density. Poplar overexpressing PpnMYC2 had higher water use efficiency and drought resistance.

RNA‐sequencing data of poplars overexpressing PpnMYC2 showed that PpnMYC2 promotes the expression of stomatal density inhibitors PagEPF2 and PagEPFL4 and inhibits the expression of the stomatal density‐positive regulator PagEPFL9. Yeast one‐hybrid system, electrophoretic mobility shift assay, ChIP‐qPCR, and dual‐luciferase assay were employed to substantiate that PpnMYC2 directly regulated PagEPF2, PagEPFL4, and PagEPFL9. PpnMYC2, PpnEPF2, and PpnEPFL4 were significantly upregulated, whereas PpnEPFL9 was downregulated during stomatal formation in triploid poplar.

Our results are of great significance for revealing the regulation mechanism of plant stomatal occurrence and polyploid stomatal density, as well as reducing stomatal density and improving plant water use efficiency by overexpressing MYC2.
Communication between undamaged plants can elicit changes in volatile emissions from neighbouring plants, thereby altering their susceptibility to aphids
Authors: Kheam Sokha , Gallinger Jannicke , Ninkovic Velemir 
Published: January 2024

AbstractPlant volatiles play an important role in intra‐ and interspecific plant communication, inducing direct and indirect defenses against insect pests. However, it remains unknown whether volatile interactions between undamaged cultivars alter host plant volatile emissions and their perception by insect pests. Here, we tested the effects of exposure of a spring barley, Hordeum vulgare L., cultivar, Salome, to volatiles from other cultivars: Fairytale and Anakin. We found that exposing Salome to Fairytale induced a significantly higher emission of trans‐β‐ocimene and two unidentified compounds compared when exposed to Anakin. Aphids were repelled at a higher concentration of trans‐β‐ocimene. Salome exposure to Fairytale had significant repulsive effects on aphid olfactory preference, yet not when Salome was exposed to Anakin. We demonstrate that volatile interactions between specific undamaged plants can induce changes in volatile emission by receiver plants enhancing certain compounds, which can disrupt aphid olfactory preferences. Our results highlight the significant roles of volatiles in plant–plant interactions, affecting plant–insect interactions in suppressing insect pests. This has important implications for crop protection and sustainable agriculture.
Autonomy and aesthetic valuing
Authors: Riggle Nick 
Published: January 2024

AbstractAccounts of aesthetic valuing emphasize two constraints on the formation of aesthetic belief. We must form our own aesthetic beliefs by engaging with aesthetic value first‐hand (the acquaintance principle) and by using our own capacities (the autonomy principle). But why? C. Thi Nguyen's proposal is that aesthetic valuing has an inverted structure. We often care about inquiry and engagement for the sake of having true beliefs, but in aesthetic engagement this is flipped: we care about arriving at good aesthetic beliefs for the sake of the values that arise in the process of doing so. The engagement is the point, so we must use our own capacities in first‐hand encounters. Here I challenge Nguyen's account. I argue that it misconstrues the value of aesthetic belief; it conflicts with restrictions on aesthetic testimony; and it has trouble harnessing engagement‐value for a theory of aesthetic value. A better approach emphasizes the social character of aesthetic valuing. On this view, aesthetic valuing is a social practice structured around the collaborative exercise and improvement of certain special capacities. The autonomy and acquaintance principles tell us to engage these capacities in forming our aesthetic beliefs. Understood aright, and contrary to consensus, these rules are identical.
Improved the in vitro blastocyst development in oocytes recovered from cyclic buffaloes
Authors: Mehmood Muhammad Usman , Riaz Amjad , Shahzad Muhammad , Naseer Zahid , Lu Kehuan , Lu Yangqing 
Published: January 2024

AbstractThis study examined the impact of cyclicity (with or without cycle corpus luteum; CL) on oocyte quality and embryonic development in buffaloes. We collected oocytes from the ovaries of slaughtered buffaloes (N = 158 cyclic; n = 316 ovaries and N = 177 acyclic; n = 353 ovaries). Blood progesterone concentration and number of oocytes per ovary were higher in cyclic buffaloes. Cyclic buffalo ovaries produce higher oocytes with I + II and fewer III + IV grades. Oocytes from cyclic buffaloes had a higher maturation rate based on cumulus expansion, cleavage rate and embryo development to the 8‐cell, morula and blastocyst stages than acyclic buffaloes. In conclusion, oocytes recovered from the ovaries of the cyclic buffaloes showed improved oocyte competence and subsequent in vitro blastocyst development.
Associations of school physical activity environment with comorbid obesity and myopia in children and adolescents: Findings from a Chinese national follow‐up study
Authors: Dang Jiajia , Cai Shan , Zhong Panliang , Liu Yunfei , Shi Di , Chen Ziyue , Chen Manman , Dong Yanhui , Ma Jun , Song Yi , Lau Patrick W. C. , Stafford Randall S. 
Published: January 2024

AbstractBackgroundOverweight and obesity (OWOB) and myopia have become two of the most important issues affecting the health of children and adolescents worldwide. Despite the recognition that the school physical activity (PA) environment is a critical factor for preventing and controlling overweight, obesity (OWOB), and myopia in children and adolescents, research on OWOB and myopia as a comorbidity remains unexplored, with evidence for effective strategies still being inconclusive. Hence, this study aimed to assess the prevalence and progression of comorbid OWOB/myopia and each condition alone, and to explore the association with school PA environment.MethodsA total of 9814 children and adolescents aged 6–18 years were included from the Chinese National Survey on Students' Constitution and Health follow‐up survey conducted from November 2019 to November 2020 in China. Anthropometric measurements, unaided distance vision acuity and non‐cycloplegic refraction data were collected to assess OWOB and myopia, while eight indicators from questionnaires for children and adolescents aged 9–18 years were investigated to assess school PA environment. We calculated the one‐year incidence and progression rates of comorbid OWOB/myopia, OWOB alone, and myopia alone. Mixed effect logistic regression was evaluated the association between school PA environment and incidence and progression of comorbid OWOB/myopia, OWOB, and myopia.ResultsThe prevalence of comorbid OWOB/myopia increased from 11.1% in 2019 to 17.9% in 2020, and the incidence of comorbid OWOB/myopia was 10.9%. Children and adolescents experiencing an unfavorable school PA environment had a higher risk of the incidence of comorbid OWOB/myopia compared to a favorable school environment (OR = 1.85, 95% CI: 1.42–2.42). Similar findings were seen in the incidence of obesity (OR = 1.86, 95% CI: 1.26–2.75). Children and adolescents in an unfavorable school PA environment had a higher risk of myopia progression (OR = 1.29, 95% CI: 1.01–1.65).ConclusionsObesity and myopia and their comorbidity have been serious among children and adolescents in China. A favorable school PA environment might mitigate the risk of comorbid OWOB/myopia, OWOB, and myopia progression.
Impact of the COVID‐19 outbreak on blood supply in two large university hospitals
Authors: Brieske Christian M. , Temme Christian , Hiller Jens , Goebel Meike , Peine Sven , Horn Peter A. 
Published: January 2024

AbstractObjectiveThis study aimed to examine the relationship between the decrease in elective procedures and the need for blood donation during the novel coronavirus disease (COVID‐19) pandemic at university hospitals.BackgroundThe COVID‐19 pandemic has immensely impacted transfusion medicine. By cancelling elective surgery, the German government hoped to increase the available resources for patients infected with COVID‐19, especially in intensive care units, and prevent the shortage of blood products.Methods/MaterialsOver 26 weeks, from the 3rd of February 2020 to the 2nd of August 2020, during the first phase of the pandemic, we assessed the number of crossmatches, blood group typing, use of donated blood, and case mix indices by retrospectively analysing data from two major university hospitals' information systems in Essen and Hamburg, Germany. Data were pooled, analysed, and compared with that of the same period in the previous year.ResultsFollowing the cessation of elective procedures, the number of requests for crossmatches and blood group typing significantly decreased in 2020 compared to that in 2019. However, the number of blood transfusions required was reduced to a lesser extent. The number of outpatient and inpatient cases significantly decreased, whereas the cases requiring transfusion decreased only.ConclusionDuring the initial phase of the pandemic, transfusion medicine, especially in large institutions, faced an almost unchanged high demand for donated blood. This should be considered regarding personnel and blood donation allocations. Therefore, we developed a monitoring system to display the availability of blood products in real‐time. The quick and easy display of in‐stock and expiring blood products can optimise the use of this valuable resource.
Mapping of cytosol‐facing organelle outer membrane proximity proteome by proximity‐dependent biotinylation in living Arabidopsis cells
Authors: Bao Xinyue , Jia Huifang , Zhang Xiaoyan , Tian Sang , Zhao Yanming , Li Xiangyun , Lin Ping , Ma Chongyang , Wang Pengcheng , Song Chun‐Peng , Zhu Xiaohong 
Published: January 2024

SUMMARYThe cytosol‐facing outer membrane (OM) of organelles communicates with other cellular compartments to exchange proteins, metabolites, and signaling molecules. Cellular surveillance systems also target OM‐resident proteins to control organellar homeostasis and ensure cell survival under stress. However, the OM proximity proteomes have never been mapped in plant cells since using traditional approaches to discover OM proteins and identify their dynamically interacting partners remains challenging. In this study, we developed an OM proximity labeling (OMPL) system using biotin ligase‐mediated proximity biotinylation to identify the proximity proteins of the OMs of mitochondria, chloroplasts, and peroxisomes in living Arabidopsis (Arabidopsis thaliana) cells. Using this approach, we mapped the OM proximity proteome of these three organelles under normal conditions and examined the effects of the ultraviolet‐B (UV‐B) or high light (HL) stress on the abundances of OM proximity proteins. We demonstrate the power of this system with the discovery of cytosolic factors and OM receptor candidates potentially involved in local protein translation and translocation. The candidate proteins that are involved in mitochondrion–peroxisome, mitochondrion–chloroplast, or peroxisome–chloroplast contacts, and in the organellar quality control system are also proposed based on OMPL analysis. OMPL‐generated OM proximity proteomes are valuable sources of candidates for functional validation and suggest directions for further investigation of important questions in cell biology.