bluuebunny/crossref_metadata_2025_split huggingface dataset:
EZH2 Inhibition Promotes Tumor Immunogenicity in Lung Squamous Cell Carcinomas
Authors: DuCote Tanner J. , Song Xiulong , Naughton Kassandra J. , Chen Fan , Plaugher Daniel R. , Childress Avery R. , Gellert Abigail R. , Skaggs Erika M. , Qu Xufeng , Liu Jinze , Liu Jinpeng , Li Fei , Wong Kwok-Kin , Brainson Christine F. 
Published: January 2024

Abstract

Two important factors that contribute to resistance to immune checkpoint inhibitors (ICI) are an immune-suppressive microenvironment and limited antigen presentation by tumor cells. In this study, we examine whether inhibition of the methyltransferase enhancer of zeste homolog 2 (EZH2) can increase ICI response in lung squamous cell carcinomas (LSCC). Our in vitro experiments using two-dimensional human cancer cell lines as well as three-dimensional murine and patient-derived organoids treated with two inhibitors of the EZH2 plus IFNγ showed that EZH2 inhibition leads to expression of both MHC class I and II (MHCI/II) expression at both the mRNA and protein levels. Chromatin immunoprecipitation sequencing confirmed loss of EZH2-mediated histone marks and gain of activating histone marks at key loci. Furthermore, we demonstrate strong tumor control in models of both autochthonous and syngeneic LSCC treated with anti-PD1 immunotherapy with EZH2 inhibition. Single-cell RNA sequencing and immune cell profiling demonstrated phenotypic changes toward more tumor suppressive phenotypes in EZH2 inhibitor–treated tumors. These results indicate that EZH2 inhibitors could increase ICI responses in patients undergoing treatment for LSCC.

Significance:
The data described here show that inhibition of the epigenetic enzyme EZH2 allows derepression of multiple immunogenicity factors in LSCC, and that EZH2 inhibition alters myeloid cells in vivo. These data support clinical translation of this combination therapy for treatment of this deadly tumor type.
Fighter Pilot Syndrome: A Bow Hunter Syndrome Variant Identified With Dynamic Cerebral Angiography
Authors: Choi Joo Won , Jin Kirsten , Wilson Jessica N. , Pham Andrew , Mehta Tej I. , Tsappidi Samuel , Zhang Jonathan Y. , Hui Ferdinand K. , Brown Stacy C. 
Published: January 2024

Background
Dynamic compression of extracranial arteries in the cervicocerebral circulation is a rare phenomenon of ischemic stroke.

Methods
Retrospective chart review.

Results
Here, we present a young fighter pilot who presented with recurrent embolic strokes of undetermined source. He endorsed flying fighter jets for 6 years, during which he was subject to high G‐force loads and extensive in‐flight head maneuvers. Extensive workup identified dynamic arterial compression of his right vertebral artery, which entered the transverse foramen at the C4 level. Dynamic cerebral angiography was used to reveal the specific vessel location and provocative maneuver leading to dynamic occlusion of his right vertebral artery.

Conclusion
This case highlights the utility of dynamic cerebral angiography in identifying previously unexplored causes of arteriogenic emboli formation, particularly in patients with predisposing anatomic and clinical risk factors.
Impact of anti-gravity muscle training protocol on plantar pressure, pain threshold and foot posture on chronic painful heel: an RCT study
Authors: Gotecha S. , Gurudut P. , Welling A. , Kage V. 
Published: January 2024

Abstract
Chronic painful heel (CPH) is a symptom of an underlying condition caused due to obesity, excessive foot pronation, tightness of Tendo-Achilles (TA), excessive running, and sedentary life. The antigravity muscles (AGM) atrophy results due to long working hours in sitting, leading to their deteriorating relationship with gravity thereby reduced sensitivity to its force. Hence, need arises to explore training effects of AGM protocol on CPH condition. A randomised controlled trial was conducted on thirty individuals with CPH allocated randomly to two study groups viz. AGMT (n = 15) and Control group (n = 15) who received intervention for twelve sessions over four weeks. Control group received conventional physiotherapy in form of therapeutic ultrasound and exercises while AGMT received conventional physiotherapy using the AGMT protocol. Outcomes assessed were plantar pressure and foot posture assessed using Harris mat, muscle strength by dynamometer, pain threshold with pressure algometer, and foot functions using Foot and Ankle Ability Measure Scale (FAAM) which were taken at pre- and post-training. The between group analysis of data revealed that foot posture, plantar pressure and muscle strength, pain threshold were significantly better in the AGMT group than in the Control group ( 0.0001), while pain intensity (P = 0.3952) and foot functions (P = 0.2372) were equally effective in both the study groups. In conclusion, the AGMT protocol along with conventional physiotherapy proved to be a promising training protocol for individuals with CPH showing positive outcomes in comparison to conventional therapy alone, suggesting to incorporate AGM strengthening alongside conventional therapy to obtain better clinical outcomes.
Trial registration: This trial was prospectively registered in the Clinical trial registry of India with registration number CTRI/2022/10/046138.
Was There a Resistance Fascism?
Authors: Rodrigo Javier , Pubill Joan 
Published: January 2024

Abstract
Is it possible to identify traces of dissent or even resistance to Francoism within a single fascist party? Can there be elements of radical opposition within fascism in its long duration? This article’s discussion of this question, centered on the Spanish Falange’s case, will focus on two main topics that define the parameters of historiographical discussion of an idealized (‘authentic’, ‘pure’, ‘uncontaminated’, ‘rebellious’) fascism that may also be useful for interpreting and establishing comparisons with other contexts. The first of these topics is the mythification of fascism’s original authenticity and the second is the preeminence of Franco’s providentialist leadership and how it explicitly demonstrates his de facto importance in the construction of the dictatorial regime as a fascist regime through the exercise of power.
“Searching for Meanings and Becoming Better Moms”
Authors: Lin Hsien-Ming 
Published: January 2024

Abstract
This article explores the education-related experiences of Vietnamese immigrant women in Taiwan. The author adopts a qualitative methodology, utilizing semi-structured interviews, followed by a constant comparative analysis. Three core themes are unearthed: the participants’ learning experiences, the process of meaning-making, and the multidimensional impacts of their education. Key findings include the effort invested by participants in obtaining familial support to pursue their education and the learning challenges posed by language barriers. Furthermore, the pursuit of education is found to extend to deeper aspects of self-identity, encompassing motherhood and empowerment. This article illustrates how higher education can facilitate better employment and enhance societal integration and intra-familial power dynamics for immigrant women. Its impact is not unilateral but spans multiple dimensions of their lives in their host society. The insights gained from this article indicate a need for broader, comparative, and diverse research to understand experiences across other immigrant communities in Taiwan.
A Dynamics-Weighted Principal Components Analysis of Dominant Atmospheric Drivers of Ocean Variability with an Application to the North Atlantic Subpolar Gyre
Authors: Amrhein Daniel E. , Stephenson Dafydd , Thompson LuAnne 
Published: January 2024

Abstract
This paper describes a framework for identifying dominant atmospheric drivers of ocean variability. The method combines statistics of atmosphere–ocean fluxes with physics from an ocean general circulation model to derive atmospheric patterns optimized to excite variability in a specified ocean quantity of interest. We first derive the method as a weighted principal components analysis and illustrate its capabilities in a toy problem. Next, we apply our analysis to the problem of interannual upper ocean heat content (HC) variability in the North Atlantic Subpolar Gyre (SPG) using the adjoint of the MITgcm and atmosphere–ocean fluxes from the ECCOv4-r4 state estimate. An unweighted principal components analysis reveals that North Atlantic heat and momentum fluxes in ECCOv4-r4 have a range of spatiotemporal patterns. By contrast, dynamics-weighted principal components analysis collapses the space of these patterns onto a small subset—principally associated with the North Atlantic Oscillation—that dominates interannual SPG HC variance. By perturbing the ECCOv4-r4 state estimate, we illustrate the pathways along which variability propagates from the atmosphere to the ocean in a nonlinear ocean model. This technique is applicable across a range of problems across Earth system components, including in the absence of a model adjoint.

Significance Statement
While the oceans have absorbed 90% of the excess heat associated with human-forced climate change, the change in the ocean’s heat content is not steady, with peaks and troughs superimposed upon a general increase. These fluctuations come from chaotic changes in the atmosphere and ocean and can be hard to disentangle. We use this case of ocean heat content variability to introduce a new method for determining the patterns of weather and climate in the atmosphere that are most effective at generating fluctuations in the ocean. To do this, we combine the statistics of recent atmospheric activity with output from a state-of-the-art numerical ocean model that reveals physical processes driving changes in ocean quantities including ocean heat content. This approach suggests that the atmospheric patterns that stimulate the most energetic changes in ocean heat content in the northern North Atlantic are not necessarily the most energetic patterns present in the atmosphere. We test our findings by preventing these patterns from affecting the ocean in our numerical model and measure a strong reduction in ocean heat content fluctuations.
Responsiveness of Patient-Reported Outcome Measures After Large Knee Articular Cartilage Transplantation: A Systematic Review and Meta-analysis
Authors: Abed Varag , Kapp Sabryn , Nichols Michael , Shephard Leah , Jacobs Cale , Conley Caitlin , Stone Austin V. 
Published: January 2024

Background: Cartilage transplantation is commonly used to treat large (>4 cm2) articular cartilage defects of the knee. The 2 most common transplants are osteochondral allograft transplantation and autologous chondrocyte implantation. Several patient-reported outcome measures (PROMs) have been used to determine the efficacy of treatment, but it is unknown which measures are the most effective. Purpose: To report the multiple PROMs used after large knee articular cartilage transplantation surgery and to compare the responsiveness between them. Study Design: Meta-analysis; Level of evidence, 4. Methods: Following Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) guidelines, a systematic search of the PubMed/MEDLINE and Web of Science databases was performed. A total of 181 articles met inclusion criteria. Patient and study characteristics were extracted, including pre- and postoperative means for PROMs. From the articles that met inclusion criteria for responsiveness analysis (2+ PROMs reported, 1-year minimum follow-up, reported pre- and postoperative means and standard deviations; n = 131), the authors compared the responsiveness between PROM instruments using effect size and relative efficiency (RE) if a PROM could be compared with another in ≥10 articles. Results: A total of 10,015 patients (10,093 knees; mean age, 34.8 years; mean body mass index, 26.1) were included in this study. The mean follow-up time was 58.3 months (range, 1.5-247.2 months), imaging findings were reported in 80 articles (44.2%), patient satisfaction was reported in 39 articles (21.5%), and range of motion was reported in 10 articles (5.5%). There were 58 unique PROM instruments identified, with the most used being the International Knee Documentation Committee (IKDC) score (n = 118; 65.2%), followed by Knee injury and Osteoarthritis Outcome Score (KOOS) Pain (n = 58; 32.0%), KOOS Sport and Recreation (n = 58; 32.0%), KOOS Quality of Life (n = 57; 31.5%), KOOS Activities of Daily Living (n = 57; 31.5%), and KOOS Symptoms (n = 57; 31.5%). Overall, IKDC was found to have the greatest effect size (1.68) and the best responsiveness of the other PROMs, which include KOOS Pain (RE, 1.38), KOOS Symptoms (RE, 3.06), KOOS Activities of Daily Living (RE, 1.65), KOOS Sport and Recreation (RE, 1.44), Lysholm (RE, 1.76), and Tegner (RE, 1.56). Conclusion: The IKDC is the most responsive PROM after large knee articular cartilage transplantation surgery. The IKDC score is recommended for assessing outcomes after cartilage transplantation surgery.
The Relation Between Adverse Childhood Experiences and Health Behaviors in Adult Women
Authors: Tavares Karina L. , Tsotsoros Cindy E. 
Published: January 2024

Purpose This study aims to identify whether adverse childhood experiences (ACEs) influence health lifestyles throughout adulthood and examine how ACEs influence dimensions of health lifestyles. Design The data was collected cross-sectionally through an online questionnaire. Setting Individuals were invited to participate in an online survey for a larger brain health study as a pre-screening measure. Subjects Women in the Midwest between 18-25 and 65-85 who reported either no ACEs or 3 or more ACEs completed the survey, with 233 women answering all questionnaires. Measures Demographic indicators, the 10-item ACEs questionnaire, and the Health Promoting Lifestyle Profile (HPLP-II). Analysis Independent sample t-tests revealed significantly lower scores for ACEs group on the HPLP-II and the 6 subcategories (heath responsibility, interpersonal relationships, nutrition, physical activity, spiritual growth, and stress management). A structural equation model using the 3 ACE categories (abuse, neglect, and household dysfunction) and 6 health domains showed substantial differences in the variance captured for each health behavior. Results Findings indicate that abuse predicts physical activity, stress management, and spiritual growth (β = −.21, −.23, −.20); neglect predicts interpersonal relationships and spiritual growth (β = −.17, −.18); and household dysfunction predicts health responsibility, nutrition, stress management, and interpersonal relations (β = −.20, −.22, −.10, −.17). Conclusion The present investigation extends research in displaying that ACEs play a significant role in future health behaviors, with household dysfunction being the greatest predictor.
COVID-19 and outcomes in Chinese peritoneal dialysis patients
Authors: Liao Ruoxi , Zhou Xueli , Ma Dengyan , Wang Shaofen , Fu Ping , Zhong Hui 
Published: January 2024

Background: Reports on COVID-19 in peritoneal dialysis (PD) patients are scarce in China. This study aimed to describe the characteristics and outcomes of PD patients with COVID-19 after China abandoned the ‘zero-COVID’ policy. Methods: This single-centre retrospective study included patients receiving PD who underwent testing for COVID-19 infections between 7 December 2022 and 7 January 2023. Outcomes of interest included factors associated with positive COVID-19 testing result and clinical outcomes including COVID-19-related hospitalisation and severe COVID-19, which were analysed using logistic regression analyses. Results: A total of 349 PD patients (male 53.6%, age 49 ± 13 years old) were included, and 235 patients (67.3%) were infected. There were no significant differences between COVID-19 and non-COVID-19 patients other than higher proportion of vaccinated patients and slow transporters in the patients who tested positive for COVID-19 (44.7% vs. 28.1%, p = 0.003; 8.7% vs. 1.8%, p = 0.03, respectively). Multivariate analysis showed COVID-19 was associated with vaccination (odds ratio (OR): 1.71, 95% confidence interval (CI): 1.02–2.86) and slow transport type (compared with average transport type, OR: 4.52, 95% CI: 1.01–20.21). Among the patients with infection, 38 (16.2%) patients were hospitalised, 18 (7.7%) patients had severe disease and 9 (3.8%) patients died. In multivariate logistic analysis, both age (OR: 1.04, 95% CI: 1.01–1.07; OR: 1.06, 95% CI: 1.02–1.11) and hyponatremia (OR: 5.44, 95% CI: 1.63–18.13; OR: 6.50, 95% CI: 1.77–23.85) were independent risk factors for COVID-19-related hospitalisation and severe disease. Conclusions: Although vaccinated patients were more likely to have tested positive for COVID-19 infection, they appeared to have less severe infection and less need for hospitalisation. Patients who were older with a history of hyponatremia were more likely to experience adverse outcomes from COVID-19.
Liver and ovarian toxicities boosted by bisphenol and gamma radiation in female albino rats
Authors: Hassan Asmaa A , Abdelgayed Sherein S , Mansour Somaya Z 
Published: January 2024

Bisphenol A (BPA), a carbon-based synthetic polymer compound, was newly classified as an environmental toxicant and an endocrine-disrupting chemical leading to abnormalities in cell proliferation, apoptosis, or migration that contributes to cancer development and progression. This study aims to evaluate the effect of the elevation of γ- radiation dose and BPA on the liver and ovaries of female rats. In this study, eighty female albino rats (130–150 g) were used in this work. Rats in this experiment received BPA in ethanol (50 mg/kg b. wt.) for 30 days, day after day, and in the irradiated groups, animals were administered BPA and then exposed to γ- radiation in doses (2, 4, and 6 Gy) one shot dose. Several members of the cytochrome family were examined. Exposure to γ-radiation and BPA showed an increase in cytochrome P450 and b5 fold change. Further, BPA and γ-radiation activate α and β estrogen receptors and also downregulate aromatase (CYT19) fold change. The current results also revealed that BPA and/or γ-radiation regulate the protein expression of the PI3K/Akt signaling pathway. The steroidogenic acute regulatory protein (StAR) appeared to be targeted by BPA and γ-radiation and its relative expression was elevated significantly by raising the γ-radiation dose. In conclusion, exposure to BPA, an endocrine-disrupting chemical, leads to marked toxicity. Additionally, toxicity is heightened by increasing the γ-radiation dose, either alone or in combination with BPA.
Characteristics of Auditory Brainstem Response in Night-shift Health Workers
Authors: Singh Samir Kumar , Rana Poonam Jyoti , Gupta Anita , Samaddar Dibyodyuti , Sharma Hanjabam Barun 
Published: January 2024

Background: With technological advancement and economic competitiveness there is an exponential rise in the number of shift workers. Worldwide, healthcare workers constitute the single largest proportion of workers who work on shift duty in order to provide round-the-clock healthcare services to patients. Various studies have demonstrated an association between circadian cycle disturbance due to shift work and adverse health impacts. Purpose: The purpose of the study was to investigate the impact of night shift work on the brainstem-evoked auditory potentials in nursing interns who had been assigned to their first night shift after working day shifts. Methods: A longitudinal, self-case-control study was designed with a sample of 67 nursing interns. Brainstem evoked response audiometry (BERA) had been done after completion of their first posting in Day-shift and then after completion of Night-shift. The paired t-test was used for data analysis. Results: The findings of the study showed significant changes in latencies of wave II ( p < .0001), wave IV ( p < .0001), wave V ( p = .012 & .30), interpeak latency III-V ( p = .009 & .003) and V/I ratio ( p < .0001) for both ears. Conclusions: BERA is an objective non-invasive test to evaluate hearing ability by measuring increased latency and interaural latency difference. After night shift, there were significant changes in auditory acuity which was highly suggestive of delayed transmission in auditory pathway. Hearing impairment has a cascading effect on cognition which may affect night-shift workers’ daily activities and may lead to medical error and risk to patient safety.
Parkinson’s Disease Carepartners’ Perceptions of the Challenges and Rewards of Caregiving
Authors: Seshadri Sandhya , Contento Angela , Sugiura Kei , Abendroth Maryann , Macchi Zachary , Kluger Benzi M. 
Published: January 2024

Background Multiple debilitating symptoms and the progressive nature of Parkinson’s disease (PD) affect carepartners’ quality of life. Although, there is abundant knowledge on caregiver burden there is limited knowledge on PD carepartners’ perceptions of caregiving. Aim To understand family members’ perception of their role, and of the challenges and rewards of PD caregiving. Method Using a qualitative descriptive research design, we conducted semi-structured interviews with current and former PD carepartners (n = 16). Interviews were audio-recorded, de-identified, and transcribed verbatim. Data were coded and analyzed to identify themes. Results We identified 5 themes: (a) Unpredictability is the hardest part of caregiving. It was hard to cope with the unpredictable daily and longer-term fluctuations in PD symptoms; (b) Disease progression and multiple symptoms contribute to carepartners’ emotional distress. Carepartners felt unprepared and were saddened by the patient’s and their own losses; (c) Caring for a family member is not a “burden.” Though stressful, carepartners resisted associating caregiving with the term “burden”; (d) Caregiving is a partnership. Carepartners saw their role as being less of “givers” and more of partners in disease management ; and (e) Caregiving is an opportunity for personal satisfaction, joy, and growth. Caregiving was seen as a “gift” that enabled carepartners to express love and experience personal growth. Conclusions Despite challenges PD carepartners view their role as “partners” in the management of the disease and find meaning and strength in caregiving. A palliative care approach emphasizing the positives and challenges of caregiving may provide carepartners with better support.