bluuebunny/crossref_metadata_2025_split huggingface dataset:
Using open educational resources in studio-based flipped classrooms: action research in video production learning
Authors: Chan Yuet Kai , Oh Jae-Eun , Ma Henry 
Published: October 2023

AbstractThis study explores the use of open educational resources (OERs) in studio-based learning and their influence on learning experiences. The research team conducted action research with 30 bachelor of arts students who were completing a video production subject. Students were required to learn from a website containing open online learning resources under a flipped classroom approach. A teaching schedule and website were designed according to several criteria. Research data were collected through observation, reflective journals, and interviews and were analyzed via thematic analysis. Participating students expressed their perceptions of benefits and hesitation in utilizing OERs in learning. They agreed that the use of OERs as flipped classroom learning materials could positively affect their learning, primarily through competence and learning autonomy as indicated in self-determination theory. This investigation provides teachers with valuable experience and suggestions for teaching and learning approaches that incorporate OERs into studio-based education. Students learn from OERs in which they can gain the most up-to-date technical knowledge in an autonomous environment. This experience indicates that this pedagogy greatly and positively influences students’ subject-learning experiences, learning outcomes, and self-learning skills.
SARS-CoV-2 spike protein S1 activates Cx43 hemichannels and disturbs intracellular Ca2+ dynamics
Authors: Prieto-Villalobos Juan , Lucero Claudia M. , Rovegno Maximiliano , Gómez Gonzalo I. , Retamal Mauricio A. , Orellana Juan A. 
Published: October 2023

Abstract
Background
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) causes the ongoing coronavirus disease 2019 (COVID-19). An aspect of high uncertainty is whether the SARS-CoV-2 per se or the systemic inflammation induced by viral infection directly affects cellular function and survival in different tissues. It has been postulated that tissue dysfunction and damage observed in COVID-19 patients may rely on the direct effects of SARS-CoV-2 viral proteins. Previous evidence indicates that the human immunodeficiency virus and its envelope protein gp120 increase the activity of connexin 43 (Cx43) hemichannels with negative repercussions for cellular function and survival. Here, we evaluated whether the spike protein S1 of SARS-CoV-2 could impact the activity of Cx43 hemichannels.

Results
We found that spike S1 time and dose-dependently increased the activity of Cx43 hemichannels in HeLa-Cx43 cells, as measured by dye uptake experiments. These responses were potentiated when the angiotensin-converting enzyme 2 (ACE2) was expressed in HeLa-Cx43 cells. Patch clamp experiments revealed that spike S1 increased unitary current events with conductances compatible with Cx43 hemichannels. In addition, Cx43 hemichannel opening evoked by spike S1 triggered the release of ATP and increased the [Ca2+]i dynamics elicited by ATP.

Conclusions
We hypothesize that Cx43 hemichannels could represent potential pharmacological targets for developing therapies to counteract SARS-CoV-2 infection and their long-term consequences.
Energy metaverse: the conceptual framework with a review of the state-of-the-art methods and technologies
Authors: Ma Zheng 
Published: October 2023

AbstractThe transition to green energy systems is vital for addressing climate change, with a focus on renewable sources like wind and solar. This change requires substantial investment, societal adaptations, and managing a complex energy ecosystem. However, no existing evaluation methods support this purpose. The "energy metaverse" is proposed as a digital platform that mirrors the energy ecosystem, enabling the design, trial, and assessment of new technologies, business models, and value chains before real-world deployment. Drawing from State-of-the-Art technologies and methodologies, this paper introduces a conceptual framework for the energy metaverse, comprising five essential components: a versatile energy ecosystem data space, an interoperable virtual ecosystem living lab, an energy system models and artificial intelligent algorithms sandbox, a circular value chain co-design toolbox, and an ecosystem lifecycle evaluation software tool. This paper also suggests specific methods and technologies to develop each of these five components of the energy metaverse.
Highly efficient flexible structured metasurface by roll-to-roll printing for diurnal radiative cooling
Authors: Lin Keng-Te , Nian Xianbo , Li Ke , Han Jihong , Zheng Nan , Lu Xiaokang , Guo Chunsheng , Lin Han , Jia Baohua 
Published: October 2023

AbstractAn ideal radiative cooler requires accurate spectral control capability to achieve efficient thermal emission in the atmospheric transparency window (8–13 μm), low solar absorption, good stability, scalability, and a simple structure for effective diurnal radiative cooling. Flexible cooling films made from polymer relying on polymer intrinsic absorbance represent a cost-effective solution but lack accuracy in spectral control. Here, we propose and demonstrate a metasurface concept enabled by periodically arranged three-dimensional (3D) trench-like structures in a thin layer of polymer for high-performance radiative cooling. The structured polymer metasurface radiative cooler is manufactured by a roll-to-roll printing method. It exhibits superior spectral breadth and selectivity, which offers outstanding omnidirectional absorption/emission (96.1%) in the atmospheric transparency window, low solar absorption (4.8%), and high stability. Impressive cooling power of 129.8 W m−2 and temperature deduction of 7 °C on a clear sky midday have been achieved, promising broad practical applications in energy saving and passive heat dispersion fields.
Severe mental illness, race/ethnicity, multimorbidity and mortality following COVID-19 infection: nationally representative cohort study
Authors: Das-Munshi Jayati , Bakolis Ioannis , Bécares Laia , Dyer Jacqueline , Hotopf Matthew , Ocloo Josephine , Stewart Robert , Stuart Ruth , Dregan Alex 
Published: October 2023

BackgroundThe association of COVID-19 with death in people with severe mental illness (SMI), and associations with multimorbidity and ethnicity, are unclear.AimsTo determine all-cause mortality in people with SMI following COVID-19 infection, and assess whether excess mortality is affected by multimorbidity or ethnicity.MethodThis was a retrospective cohort study using primary care data from the Clinical Practice Research Database, from February 2020 to April 2021. Cox proportional hazards regression was used to estimate the effect of SMI on all-cause mortality during the first two waves of the COVID-19 pandemic.ResultsAmong 7146 people with SMI (56% female), there was a higher prevalence of multimorbidity compared with the non-SMI control group (n = 653 024, 55% female). Following COVID-19 infection, the SMI group experienced a greater risk of death compared with controls (adjusted hazard ratio (aHR) 1.53, 95% CI 1.39–1.68). Black Caribbean/Black African people were more likely to die from COVID-19 compared with White people (aHR = 1.22, 95% CI 1.12–1.34), with similar associations in the SMI group and non-SMI group (P for interaction = 0.73). Following infection with COVID-19, for every additional multimorbidity condition, the aHR for death was 1.06 (95% CI 1.01–1.10) in the SMI stratum and 1.16 (95% CI 1.15–1.17) in the non-SMI stratum (P for interaction = 0.001).ConclusionsFollowing COVID-19 infection, patients with SMI were at an elevated risk of death, further magnified by multimorbidity. Black Caribbean/Black African people had a higher risk of death from COVID-19 than White people, and this inequity was similar for the SMI group and the control group.
Deconstructing the English Major in Senior Capstone Courses
Authors: Stewart Jennifer 
Published: October 2023

AbstractThis article offers a rationale and model for a reflective capstone course for English majors. Rooted in the SoTL concepts of active transfer and project-based experiential learning, this course asks students to reflect on and analyze their undergraduate work while developing a toolkit to articulate the value of their humanities degrees. Toward that end, students create scaffolded professional projects in multiple genres that help them highlight the soft skills they have developed in their academic career.
Teaching Amos Tutuola's The Palm-Wine Drinkard as Part of a Decolonial Literature Syllabus
Authors: Fyfe Alexander 
Published: October 2023

Abstract
This essay argues that The Palm-Wine Drinkard ([1952] 2014), a tale of a quest through the African bush by the Nigerian writer Amos Tutuola, does important decolonial work and is therefore an excellent candidate for inclusion on a literature syllabus that aims to introduce students to decolonial thinking. After introducing Tutuola's work and considering some of the issues at stake for a decolonial pedagogy, it argues that Drinkard provides an active reading experience that creates powerful opportunities in the classroom to challenge students’ assumptions about how colonialism was experienced by colonized populations, the valences of the human, and uses of the English language. In so doing, the essay highlights potential teachable moments in the text that may be useful to instructors who wish to adopt a decolonial approach in their literature courses.
“Both by Sea and Land”
Authors: DeLancey Julia A. 
Published: October 2023

Writing some hundred years after the publication of Jacopo de’ Barbari and Anton Kolb’s celebrated View of Venice, Thomas Coryat stated of the Venetian empire: “All these territories both by sea and land do yield them . . . exceeding great revenue.” Chapter 21 explores how the View illuminates a variety of aspects of the lucrative mercantile activity for which Venice was so famous. This stunning print maps the vessels, buildings, and waterways essential for Venetian mercantile activity: it shows a variety of types of ships and boats, many of which would have been used in the movement of goods into, out of, and around Venice; it reveals the ways in which Venetian waterways aided not only in the movement of goods but also in trade and networks; and it lays out the built fabric of the city and how that built fabric fostered interconnections between merchants, goods, and families.
Dynamic metabolism during early mammalian embryogenesis
Authors: Zhao Jing , Wang Wenjie , Zhang Ling , Zhang Jia , Sturmey Roger , Zhang Jin 
Published: October 2023

ABSTRACT
Dynamic metabolism is exhibited by early mammalian embryos to support changing cell fates during development. It is widely acknowledged that metabolic pathways not only satisfy cellular energetic demands, but also play pivotal roles in the process of cell signalling, gene regulation, cell proliferation and differentiation. Recently, various new technological advances have been made in metabolomics and computational analysis, deepening our understanding of the crucial role of dynamic metabolism during early mammalian embryogenesis. In this Review, we summarize recent studies on oocyte and embryo metabolism and its regulation, with a particular focus on its association with key developmental events such as fertilization, zygote genome activation and cell fate determination. In addition, we discuss the mechanisms of certain metabolites that, in addition to serving as energy sources, contribute to epigenetic modifications.
Clinical study of Edaravone Dexborneol combined with Tirofiban in treatment of Acute Cerebral Infarction
Authors: Mi Yuxia , Hou Zhigang , Liu Jiaqi , Zhang Caixia 
Published: October 2023

Objective: To explore the clinical efficacy and safety of edaravone dexborneol combined with tirofiban in the treatment of acute cerebral infarction.
Methods: This is a retrospective study. A total of 80 patients with acute cerebral infarction (ACI) treated in Cangzhou People’s Hospital from March 2018 to December 2021 were selected, and randomly divided into the routine group(n=40) and intervention group(n=40) according to the principle of random draw. Neurological deficits in the two groups were evaluated and compared before and after treatment using the National Institutes of Health Stroke Scale (NIHSS). The quality of life of the patients was evaluated by the modified Rankin Scale (mRS).
Results: Before treatment, NIHSS and mRS scores of the two groups were not statistically significant(p>0.05); the levels of Vmin and Qmin in the two groups showed no statistical significance(p>0.05); no statistical significance was found in CRP or IL-6 levels between the two groups(p>0.05). After treatment for 14 days, the NIHSS and mRS scores of the two groups both decreased, which was more significant in the intervention group(p<0.05); Vmin and Qmin levels increased in both groups, which was more obvious in the intervention group(p<0.05); CRP and IL-6 levels reduced in both groups, which was more remarkable in the intervention group(p<0.05). The incidences of relevant adverse drug reactions presented no differences between the two groups during treatment(p>0.05).
Conclusion: Edaravone dexborneol combined with tirofiban in the treatment of ACI can effectively improve patients’ neurological deficits, quality of life and cerebral blood flow, and reduce inflammatory factor levels, have significant clinical efficacy and high clinical treatment safety.
doi: https://doi.org/10.12669/pjms.40.1.7630
How to cite this: Mi Y, Hou Z, Liu J, Zhang C. Clinical study of Edaravone Dexborneol combined with Tirofiban in treatment of Acute Cerebral Infarction. Pak J Med Sci. 2024;40(1):---------. doi: https://doi.org/10.12669/pjms.40.1.7630
This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/3.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
Assessment of prescription writing skills among dental house officers: A multi-center study
Authors: Babar Palwasha , Qaiser Uswa , Rahman Ijaz ur 
Published: October 2023

Objective: To assess the knowledge and skills of prescription writing among dental house officers from different hospitals.
Methods: This cross-sectional study was conducted from July to September, 2022. A self-administered, structured questionnaire was used to collect data from 180 house officers from four teaching dental hospitals (n=45 each). The participants were asked to write a prescription for an adult and a pediatric patient. The prescription was evaluated according to WHO criteria. Analysis was done using SPSS v.20. Data was presented as frequencies and percentages.
Results: Among the 180 participants, 42.9% were males and 57.1% were females. 33.9% participants reported prescription writing to be a difficult task. Only 36.7% participants reported to be trained in prescribing pediatric medications. None of the prescriptions completely fulfilled the WHO criteria. Doctor related information (name, address and contact no) was written by only 3.8% of the participants while 10% of the participants mentioned the patient related information (name, address and age). Dosage of the prescribed drugs was the most commonly drug-related missing parameter which was mentioned in 30% of the pediatric prescriptions and 21% of the adult prescriptions.
Conclusion: There is a general lack of knowledge among the dental house officers regarding prescription writing as they were found to be unaware of the essential elements of a prescription. The findings call for an urgent change in the undergraduate teaching of prescription writing skills with special emphasis on pediatric drugs and dosage.
doi: https://doi.org/10.12669/pjms.40.1.7688
How to cite this: Babar P, Qaiser U, Ijaz ur Rehman. Assessment of prescription writing skills among dental house officers: A multi-center study. Pak J Med Sci. 2024;40(1):---------. doi: https://doi.org/10.12669/pjms.40.1.7688
This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/3.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
Development of a national point-of-care ultrasound training course for physicians in Japan: A 3-year evaluation
Authors: Yamada Toru , Minami Taro , Kitano Yuka , Yoshino Shunpei , Mabuchi Suguru , Soni Nilam J. 
Published: October 2023

Purpose: Point-of-care ultrasound (POCUS) allows bedside clinicians to acquire, interpret, and integrate ultrasound images into patient care. Although the availability of POCUS training courses has increased, the educational effectiveness of these courses is unclear. Methods: From 2017 to 2019, we investigated the educational effectiveness of a standardized 2-day hands-on POCUS training course and changes in pre- and post-course exam scores in relationship to participants’ (n = 571) clinical rank, years of POCUS experience, and frequency of POCUS use in clinical practice. Results: The mean pre- and post-course examination scores were 67.2 (standard deviation [SD] 12.3) and 79.7 (SD 9.7), respectively. Higher pre-course examination scores were associated with higher clinical rank, more years of POCUS experience, and more frequent POCUS use (p < 0.05). All participants showed significant changes in pre- to post-course exam scores. Though pre-course scores differed by clinical rank, POCUS experience, and frequency of POCUS use, differences in post-course scores according to participant baseline differences were non-significant. Conclusion: A standardized hands-on POCUS training course is effective for improving POCUS knowledge regardless of baseline differences in clinical rank, POCUS experience, or frequency of POCUS use. Future studies shall evaluate changes in POCUS use in clinical practice after POCUS training.
Why Is There a Trefoil Motif From Karja Church in Pikk Street in Tallinn? Based on the Example of the Restoration of the In-Situ Gothic Portal in Pikk Street 7, How Medieval Is the Medieval Architecture of Tallinn Old Town?
Authors: Paju Risto 
Published: October 2023

Although Tallinn is known for its authentic medieval architecture,the closer to details we delve, to view the medieval buildings fromthe perspective of particulars, or the history of things, following themethod of its apologist Ivan Gaskell, and take one concrete artefact asa starting point and basis, the more variegated the picture becomes.The portal of the medieval building in Pikk Street 7 contains someof the more interesting restoration questions. This article here looks atthe story of the restoration of a Gothic portal of a medieval residencein Tallinn. When we stand on Pikk Street today and take a cursorylook at the portal of the house number 7, with the masonry windowson either side of it, it may seem that this medieval portal ensemble
has survived as well as the one in Vene 17 in Tallinn. However, theportal of Pikk 7 has been chosen as the subject of this article because itcontains one of the most interesting and well-documented restorationstories of a medieval Gothic portal in Tallinn Old Town. How did ithappen that these two leave a similar impression?The article submits that the residence at Pikk 7 is indeed partiallypart of the medieval stonemasonry tradition of Tallinn, but certainlyto a lesser extent than the portal of Vene 17, which has survived in itsoriginal shape and place and has not been demolished and restored.The perspective portal of Pikk 7 is medieval to the same extent asit is from the 20th century and adds to the restoration history ofTallinn as much as to the studies of the medieval architecture ofTallinn. The Middle Ages have been the main target era and Gothicthe main target style of the restoration of the building at Pikk 7 – theend results have been aimed at the dominance of those. However, itwas decided not to restore the high gable with the blind niches thatcharacterise the medieval residences of Tallinn.To conclude, a fitting thought from Juhan Maiste, ‘Every singlething has a double meaning which tells us of the people to whomthose things once used to belong, but also of those who have cleanedand restored them, brought them, whether in their natural form oras a verbal text, back into the light.’ (Juhan Maiste, “Arvustus: Tagasi asjade juurde. Raimo Pullat. Tallinlase asjademaailmvalgustussajandil”, Akadeemia, 9 (2017), 1694.)The article is based on official restoration documentation,restoration critique in the press, and personal work memoirs ofrestorer Aarne Joonsaar.
DATING THE NEWLY DISCOVERED CEILING PAINTING IN THE HOUSE OF ESTLAND’S NOBILITY IN TALLINN
Authors: Hiiop Hilkka , Läänelaid Alar , Vinnal Hannes 
Published: October 2023

In the course of renovating the Estonian Knighthood (Ritterschaft)House in the autumn of 2022, a magnificent find came to light in theceiling of a first floor room – a figural plafond painting on a canvasattached to the ceiling. This find is sensational since it adds to thenumber of rare and fragile canvas plafonds, only a few of whichsurvive in Estonia. This article demonstrates how archival researchand dendrochronology can work together hand in hand. Accordingto historical documents, this part of the Knighthood House was builtaround the year 1690, because it was described as nearly finishedin the spring of 1691. By applying dendrochronological dating, it
was possible to ascertain that the trees that form the main woodenstructures were felled after the growing season of 1689 and wereused in construction, probably in 1690. The Üxküll family of Vigalamanor sold their newly completed town palace to the Knighthood ofEstonia in 1694 for unknown reasons. The plafond painting probablyoriginates from the period between those two dates, 1690 and 1694.Thus, the Knighthood House’s plafond ceiling is the only firmlydated painting of this kind in Estonian architecture. It originatesfrom an earlier period than most other plafond paintings in Tallinn,which are assessed using stylistic comparison as dating from theperiod after the Great Northern War, specifically from 1721 to 1760.The nearly 60 m2 plafond is certainly the largest in Estonia. The useof distemper and oil paint techniques together makes this paintingremarkable. It is also the only known plafond with more than onepainting layer from different periods. At the time of writing, thepainting has not yet been exposed to view. Its thematic subject matterand the details of its technical realisation will be revealed onlyafter its restoration. The question of the authorship of the plafondpainting also remains unanswered at this stage. The overpaintingwith Rococo ornamentation covering the original painting can becautiously associated with the name of the guild painter, GotthardHolm, who was paid for work done in the Knighthood House inthe 1760s.
Mindfulness as a Potential Moderator Between Child Behavior Problems and Maternal Well-Being
Authors: Griffith Gemma M. , Saville Christopher W. N. , Halstead Elizabeth J. , Hastings Richard P. 
Published: October 2023

Abstract
Mindfulness-based programs can help lower psychological distress among parents of children with developmental disabilities. However, less is known about the functions of mindfulness in relation to parental outcomes. In a cross-sectional survey, mothers of children with developmental disabilities (N = 313) reported on their child’s behavior problems, trait mindfulness, mindful parenting, and a range of outcomes (anxiety and depression symptoms, parenting stress, family satisfaction, and positive gain). Neither trait mindfulness or mindful parenting acted as moderators between child behavior problems and outcome variables, although both had main effect (compensatory) associations with parent outcomes. Benefits of mindfulness-based programs may be general rather than specifically in the context of high child behavior problems, given the lack of evidence for the moderating function of mindfulness.