bluuebunny/crossref_metadata_2025_split huggingface dataset:
SAT043 Chronically High Cerebrospinal Fluid Glucose Levels Impair Memory In Male Mice
Authors: Raza Muhammad U , Chhabra Kavaljit H 
Published: October 2023

Abstract
Disclosure: M.U. Raza: None. K.H. Chhabra: None.
Diabetes doubles the risk of cognitive decline and Alzheimer’s disease (AD). Whether this is mediated by an increase in blood glucose or cerebrospinal fluid (CSF) glucose levels, or by other metabolic factors such as changes in plasma insulin levels is unclear. To clarify the contribution of high blood glucose versus high CSF glucose levels toward increasing the risk of cognitive decline in mice, we have developed a method through which glucose concentration can be increased selectively in CSF. We implanted 8 weeks old male mice (n= 7-8 / group) with cannula attached to osmotic minipumps to directly infuse either artificial CSF (aCSF/sham group) or 50% glucose solution (treatment group) into the right lateral ventricle for eight weeks at a flow rate of 0.25ul/hr. CSF glucose was measured two and eight weeks after initiating the infusion in these mice. We also performed oral glucose tolerance tests (OGTT) in these mice to assess their peripheral glucose metabolism and uptake. Moreover, these mice were tested through the Morris water maze (MWM) to investigate the effects of high CSF glucose on learning and memory. Mice in the treatment group showed a significant increase (p&lt;0.0001, unpaired t-test) in CSF glucose levels (mean=328±30.15 and 358±15.03mg/dl post-2, and 8 weeks of implantation, respectively) as compared to the sham group (mean=56±2.63 and 73±8.61mg/dl post-2, and 8 weeks of implantation, respectively). There was no significant change in body weight and food intake during the study. In OGTT, the treatment group showed significantly lower blood glucose levels (p&lt;0.05, two-way ANOVA repeated measures design, Bonferroni’s multiple comparisons) at 15 minutes post-gavage (mean=336.3±24.41mg/dl) as compared to the sham group (mean=478.6±30.06 mg/dl). Mice in the treatment group made significantly fewer entries to the correct quadrant (i.e. the quadrant where the hidden platform was placed during training) (mean=12.43±1.55 entries, p&lt;0.05, unpaired t-test) in the MWM test, as compared to the sham group (mean=18.4±1.84 entries). Additionally, mice in the treatment group were significantly less likely to revisit the correct quadrant (mean=10.7±1.50 revisits, p&lt;0.05, unpaired t-test) than the mice in the sham group (mean=16.8±1.78 revisits). Importantly, there was no significant difference in the overall locomotor activity between the groups as measured through the open field test. To summarize, we have developed a method to test the effects of high CSF glucose levels on learning and memory in mice. Our results show that high CSF glucose levels for up to two months cause memory deficits in mice. This mouse model of chronically high CSF glucose presents a useful tool to investigate how diabetes-associated dysregulation of glucose homeostasis in the brain may contribute to AD and other neurodegenerative disorders.
Presentation: Saturday, June 17, 2023
Population Pharmacokinetics of Single Bolus Dose Fentanyl in Obese Children
Authors: Okada Carol R. , Henthorn Thomas K. , Zuk Jeannie , Sempio Cristina , Roosevelt Genie , Ruiz Amanda G. , Cohen Mindy N. , Chatterjee Debnath , Galinkin Jeffrey L. 
Published: October 2023

BACKGROUND:
Childhood obesity is a significant problem. Obesity may alter the pharmacokinetics (PKs) of medications. Fentanyl is commonly used for procedural sedation, but there is a paucity of bolus dose fentanyl PK data in obese children. Better understanding of fentanyl PK in obese children would facilitate dosing recommendations. We conducted a study involving children with and without obesity to assess the potential differences in bolus dose fentanyl PK between the 2 groups.

METHODS:
We enrolled children 2 to 12 years of age with and without obesity, defined as >95th percentile body mass index (BMI) for age and sex, undergoing elective tonsillectomy ± adenoidectomy. After induction, subjects had 2 intravenous (IV) lines placed in 2 different extremities: 1 for medications and IV fluids and 1 for obtaining blood aliquots for fentanyl concentration analysis. After administration of 1 mcg/kg of fentanyl based on total body weight (TBW), blood sample collections for fentanyl concentration analysis were attempted at 5, 15, 30, 60, 90, and 120 minutes. Five-minute fentanyl concentrations were compared between obese and nonobese cohorts. Population PK analysis to examine the differences between obese and nonobese children was performed and included various body size descriptors, such as TBW, BMI, and fat-free mass (FFM), to examine their influence on model parameters.

RESULTS:
Half of the 30 subjects were obese. Mean fentanyl concentrations at 5 minutes were 0.53 ng/mL for the nonobese group and 0.88 ng/mL for the obese group, difference 0.35 ng/mL (95% CI, 0.08–0.61 ng/mL; P = .01). Population PK analysis showed that FFM was a significant covariate for the central volume of distribution. The potential clinical effect of an IV bolus dose of fentanyl based on TBW versus FFM in an obese child was assessed in a simulation using our model. 1 mcg/kg fentanyl dose based on TBW resulted in an approximately 60% higher peak fentanyl effect site concentration than dosing based on FFM.

CONCLUSIONS:
Our data demonstrated higher peak plasma fentanyl concentrations in obese compared to nonobese subjects. Population PK analysis found that FFM was a significant covariate for the central volume of distribution. Model simulation showed dosing of fentanyl in obese children based on TBW resulted in significantly higher peak concentrations than dosing based on FFM. Based on this modeling and the known concentration-effect relationship between fentanyl and adverse effects, our results suggest that bolus dosing of fentanyl in obese children should be based on FFM rather than TBW, particularly for procedures of short duration.
Autopsy, Patrimony, and a Christianized Reforma: Manuel Ramírez Aparicio's Mexican Conventual History, 1861–1862
Authors: Mächler Alejandro Quintero 
Published: October 2023

Abstract
The article offers a contextualized introduction to one of the most interesting and understudied Spanish American responses to mid-nineteenth-century anticlericalism: Manuel Ramírez Aparicio's Los conventos suprimidos en México (1861–62), a unique assessment of the Reforma's aftermath and a pioneering historiographical effort eluding any facile categorization. Penned by a moderate Liberal who did not endorse the obliteration of the Catholic legacy, it inaugurated the conventual history genre in Mexico, the first of many textual and visual efforts to preserve the receding religious memory in print. The article highlights the first-person autopsy regime that determined the work's methodology, uncovers the assumptions that underlay Ramírez Aparicio's conception of inevitable historical change, and showcases how the notion of national material patrimony, paired with the idea of a Christianized Reforma, aimed at guaranteeing the permanence of all that was noble, admirable, and beneficial in conventual life while reconciling it with the Liberal Party's main tenets.
Astronomy and Politics in Chile: The Role of Friedrich Ristenpart, Director of the National Astronomical Observatory, in the Dissemination and Popularization of Science, 1909–1911
Authors: Ramírez Errázuriz Verónica , Leyton Alvarado Patricio 
Published: October 2023

Abstract
This article examines Friedrich Ristenpart's role in popularizing scientific knowledge as director of the National Astronomical Observatory in Santiago, Chile, from 1909 to 1911. Our analysis centers on four scientific texts that he published with the aim of reaching a wider reading public; we also draw on press releases and administrative documents, among other sources. We posit that Ristenpart's role in popularizing scientific knowledge was closely aligned with Chilean president Pedro Montt's political agenda to modernize the nation by establishing new scientific institutions, restoring old ones, and using the 1910 centennial of Chilean independence to showcase these institutional advances. This essay also explores why Ristenpart's communicative strategy, which was dependent on the incumbent government's power, made it difficult for him to cultivate local buy-in and ultimately realize his goal of popularizing scientific knowledge.
A New Treatment Strategy for Spinal Metastasis: The “Systemic Conditions, Effectiveness of Systemic Treatment, Neurology, and Oncology” Decision Framework System
Authors: Cao Xuyong , Jiang Weihao , Zhang Bin , Zhao Xiongwei , Yu Haikuan , Lei Mingxing , Cao Yuncen , Su Xiuyun , Liu Yaosheng 
Published: October 2023

BACKGROUND AND OBJECTIVES:
Treating metastatic spinal tumors poses a significant challenge because there are currently no universally applied guidelines for managing spinal metastases. This study aims to propose a new decision framework for the 12-point epidural spinal cord compression grading system to treat patients with metastatic spinal tumors and investigate its clinical effectiveness in a multicenter analysis.

METHODS:
This study analyzed 940 patients with metastatic spinal tumors between December 2017 and March 2023. The study provided the clinical evidence for the systemic conditions, effectiveness of systemic treatment, neurology, and oncology (SENO) decision framework among spine metastases. The SENO decision framework was launched in January 2021 in our hospitals, classifying patients into 2 groups: The non-SENO group (n = 489) consisted of patients treated between December 2017 and January 2021, while the SENO group (n = 451) comprised patients treated from January 2021 to March 2023.

RESULTS:
Patients in the SENO group were more likely to receive minimally invasive surgery (67.85% vs 58.69%) and less chance of receiving spinal cord circular decompression surgery (14.41% vs 24.74%) than patients in the non-SENO group (P < .001). Furthermore, patients in the SENO group experienced fewer perioperative complications (9.09% vs 15.34%, P = .004), incurred lower hospitalization costs (P < .001), had shorter length of hospitalization (P < .001), and received systematic treatments for tumors earlier (P < .001). As a result, patients in the SENO group (329.00 [95% CI: 292.06-365.94] days) demonstrated significantly improved survival outcomes compared with those in the non-SENO group (279.00 [95% CI: 256.91-301.09], days) (P < .001). At 3 months postdischarge, patients in the SENO group reported greater improvements in their quality of life, encompassing physical, social, emotional, and functional well-being, when compared with patients in the non-SENO group.

CONCLUSION:
The SENO decision framework is a promising approach for treating patients with metastatic spinal tumors.
Cholelithiasis - current knowledge about one of the most common diseases of the digestive system
Authors: Demidowicz Gabriela , Lasota Nina , Trąbka Natalia , Younes Martyna , Kowalczyk Klaudia , Cichoń Katarzyna , Chyćko Małgorzata , Czarnota Julia , Wiśniewski Wojciech , Lambach Maciej 
Published: October 2023

Introduction: Cholelithiasis is one of the most common diseases of the digestive system and thus the most common cause of hospitalization in gastroenterology. According to the European Association for the Study of the Liver (EASL), it affects up to 20% of the European population and about 10-20% of the Polish population, and the number of patients is constantly increasing. This may be related to the growing problem of obesity and the widespread use of ultrasonography. The disease is also becoming more common in children and adolescents. The costs of gallstone diagnosis and treatment cause a huge financial burden on the health care system. As such, it is a public health issue that deserves more attention.

Aim of the study: The aim of this review is to present current and the most important information about cholelithiasis – to determine the association between prevention and cholelithiasis, describe diagnosis, treatment and complications.

Materials and methods: The review was based on the analysis of materials collected in the „Pubmed” database, Google Scholar, European Society for the Study of the Liver guidelines (EASL), books and other scientific articles. The search was performer using the key words: „cholelithiasis”, „cholelithiasis treatment”, „cholelithiasis diet”, „gallstone disease”,” gallstones”, „cholelithiasis etiology”, „Biliary Colic”

Summary: Cholelithiasis is currently the most common disease of the bile ducts. The increasing incidence of patients with gallstones should contribute to the increased interest in this disease.
Managing Volunteers and Paid Workers in a Nonprofit Operation
Authors: Berenguer Gemma , Haskell William B. , Li Lei 
Published: October 2023

Some nonprofit organizations (NPOs) manage a complex workforce composed of a mix of volunteers, part-time workers, and full-time workers. We study the NPO’s finite-horizon staffing problem to determine the optimal initial staff planning decisions and per period optimal hiring and assignment decisions given a budget, capacity constraints, and an uncertain supply of volunteers and part-time workers. Our main goal is to solve this problem in a way that is effective and easy to implement while obtaining interesting managerial insights. To this end, we first demonstrate that the optimal staffing policies are computationally challenging to identify in general. However, we demonstrate that a prioritization assignment policy and a hire-up-to policy for part-time workers can be conveniently applied and are close to optimal. These policies are, in fact, optimal under staff scarcity and staff sufficiency. In our numerical analysis, we study the value and impact of the general optimal solution that considers flexibility and turnover of part-time workers versus the prioritization assignment policy and a constant hire-up-to policy that omit flexibility and turnover behaviors. We further suggest two easy-to-implement heuristics and theoretically analyze them and run a numerical performance study. We observe that both heuristics have low relative optimality gaps. Finally, we extend our analysis by studying how the optimal policy varies under three different practical considerations: a concave social value objective, nonzero volunteer costs, and dynamic volunteer behaviors. This paper was accepted by Jayashankar Swaminathan, operations management. Funding: This work was supported by the Comunidad de Madrid [Grant EPUC3M12], the Ministerio de Ciencia e Innovación [Grant PID2021-127657NA-I00], and the Ramon y Cajal Fellowship [RYC2020-029303-I]. Supplemental Material: The data files and online appendices are available at https://doi.org/10.1287/mnsc.2023.4923 .
Stochastic Localization Methods for Convex Discrete Optimization via Simulation
Authors: Zhang Haixiang , Zheng Zeyu , Lavaei Javad 
Published: October 2023

Solving Convex Discrete Optimization via Simulation via Stochastic Localization Algorithms Many decision-making problems in operations research and management science require the optimization of large-scale complex stochastic systems. For a number of applications, the objective function exhibits convexity in the discrete decision variables or the problem can be transformed into a convex one. In “Stochastic Localization Methods for Convex Discrete Optimization via Simulation,” Zhang, Zheng, and Lavaei propose provably efficient simulation-optimization algorithms for general large-scale convex discrete optimization via simulation problems. By utilizing the convex structure and the idea of localization and cutting-plane methods, the developed stochastic localization algorithms demonstrate a polynomial dependence on the dimension and scale of the decision space. In addition, the simulation cost is upper bounded by a value that is independent of the objective function. The stochastic localization methods also exhibit a superior numerical performance compared with existing algorithms.
National variation in prophylactic antibiotic use for elective primary total joint replacement
Authors: Mabrouk Ahmed , Abouharb Alexander , Stewart Gabriel , Palan Jeya , Pandit Hemant 
Published: October 2023

AimsProphylactic antibiotic regimens for elective primary total hip and knee arthroplasty vary widely across hospitals and trusts in the UK. This study aimed to identify antibiotic prophylaxis regimens currently in use for elective primary arthroplasty across the UK, establish variations in antibiotic prophylaxis regimens and their impact on the risk of periprosthetic joint infection (PJI) in the first-year post-index procedure, and evaluate adherence to current international consensus guidance.MethodsThe guidelines for the primary and alternative recommended prophylactic antibiotic regimens in clean orthopaedic surgery (primary arthroplasty) for 109 hospitals and trusts across the UK were sought by searching each trust and hospital’s website (intranet webpages), and by using the MicroGuide app. The mean cost of each antibiotic regimen was calculated using price data from the British National Formulary (BNF). Regimens were then compared to the 2018 Philadelphia Consensus Guidance, to evaluate adherence to international guidance.ResultsThe primary choice and dosing of the prophylactic antimicrobial regimens varied widely. The two most used regimens were combined teicoplanin and gentamicin, and cefuroxime followed by two or three doses of cefuroxime eight-hourly, recommended by 24 centres (22.02%) each. The alternative choice and dosing of the prophylactic antimicrobial regimen also varied widely across the 83 centres with data available. Prophylaxis regimens across some centres fail to cover the likeliest causes of surgical site infection (SSI). Five centres (4.59%) recommend co-amoxiclav, which confers no Staphylococcus coverage, while 33 centres (30.28%) recommend cefuroxime, which confers no Enterococcus coverage. Limited adherence to 2018 Philadelphia Consensus Guidance was observed, with 67 centres (61.50%) not including a cephalosporin in their guidance.ConclusionThis analysis of guidance on antimicrobial prophylaxis in primary arthroplasty across 109 hospitals and trusts in the UK has identified widespread variation in primary and alternative antimicrobial regimens currently recommended.Cite this article: Bone Jt Open 2023;4(10):742–749.
Gendering detention: (re)producing vulnerability for migrant women in British Immigration Removal Centres
Authors: Crossley Megan 
Published: October 2023

Less than 10% of migrants in immigration detention in the UK are women, despite high-profile cases such as Yarl’s Wood IRC, and so previous research concerned with the experience of detention focuses on the general migrant population which consists mainly of men. Therein lies an uncomfortable gendered nexus between a feminised vulnerability which sustains anti-detention narratives and the somatic masculinity of the detention estate. The experiences of men are treated as the norm, despite the differing and gendered experiences of detained women.
This article addresses this gap by drawing together theoretical and empirical literature focusing on the experiences of migrant women detained in the UK and conceptualising Immigration Removal Centres (IRCs) as a microcosm through which to theorise the control and dehumanisation of migrant bodies within the contemporary context of the ‘Hostile Environment’. In particular, this article pays close attention to the intersection of gender and immigration status for migrant detainees as their experiences of pregnancy, sex work and sexual violence implicate how they experience detention.
Art as a Language for Autism: Building Effective Therapeutic Relationships with Children and Adolescents, Jane Ferris Richardson (2023)
Authors: Demaine Krystal L. 
Published: October 2023

Review of: Art as a Language for Autism: Building Effective Therapeutic Relationships with Children and Adolescents, Jane Ferris Richardson (2023)
New York: Routledge, 214 pp.,
ISBN 978-1-31517-330-6, e-book, $31.96
The Social Impact of Creative Arts in Australian Communities, Sandra Gattenhof, Donna Hancox, Helen Klaebe and Sasha Mackay (2021)
Authors: Dennis Rea 
Published: October 2023

Review of: The Social Impact of Creative Arts in Australian Communities, Sandra Gattenhof, Donna Hancox, Helen Klaebe and Sasha Mackay (2021)
Singapore: Springer, 142 pp.,
ISBN 978-9-81167-357-3, e-book, €106.99
Do mutations modifying the leaf area (nr3) and the number of potential seeds (dfc) influence photosynthetic gas exchange characteristics in common buckwheat Fagopyrum esculentum Moench?
Authors: FESENKO Ivan N. , AMELIN Alexandr V. , FESENKO Aleksey N. , BIRYUKOVA Oksana V. , ZAIKIN Valeriy V. , CHEKALIN Evgeniy I. , IKUSOV Roman A. 
Published: October 2023

Contemporary buckwheat breeding in Russia is based mainly on a Mendelian mutation det. Some additional mutations are being considered for inclusion in buckwheat breeding programs. Among them are the nr3 (narrow leaf 3) and dfc (determinate floret cluster). We evaluated the effects of the mutations on both the characteristics of photosynthetic gas exchange and the number of seeds per plant. The nr3 reduces the leaf surface area by 1.4 times. The mutant plants show some compensatory increase in photosynthesis rate, which, however, is not enough to reach the level of the source ability as in the wild type since the number of seeds per plant is significantly decreased. The possibility of using this mutation in buckwheat breeding depends on the accumulation of modifiers that increase either leaf size or photosynthesis rate. The reduced number of flowers of the dfs mutation is compensated by an increase in flower fertility, and the number of seeds per plant does not change compared to the wild type. It explains the absence of differences between the dfs and wild type in terms of the photosynthesis rate. This experiment did not reveal any problems for using the dfc mutation in breeding. In general, the results of the work support the photosynthesis rate in buckwheat is regulated based on the source-sink ratio.
Optimización de un método de cribado rápido de fármacos en sangre mediante la técnica de cromatografía de líquidos acoplada a espectrometría de masas
Authors: Rodrigo Valero Alba M. , Quintela Jorge Oscar , Bravo Serrano Begoña , Ayuso Tejedor Sara 
Published: October 2023

Resumen

Objetivos
La cromatografía líquida acoplada a la espectrometría de masas ha ganado en popularidad en los laboratorios en los últimos años debido a una mayor especificidad de la técnica, la posibilidad de determinar múltiples analitos en una sola inyección de la muestra, la medición de analitos en una variedad de matrices diferentes y a una drástica reducción de las interferencias analíticas en comparación con el inmunoensayo. El tratamiento y preparación de las muestras biológicas es un proceso esencial cuando éstas han de ser analizadas mediante sistemas cromatográficos. Los principales interferentes en el análisis de las muestras de sangre son los fosfolípidos y las proteínas. El objetivo principal de este estudio es mejorar la sistemática analítica toxicológica en el cribado general de fármacos mediante la técnica LC-MS/MS a través de un nuevo método de preparación de muestras en sangre basado en la precipitación de proteínas y eliminación de fosfolípidos.

Métodos
Se ha evaluado el nuevo método de preparación de muestras en sangre basado en la precipitación de proteínas y eliminación de fosfolípidos mediante la tecnología LC-Q-q-LIT.

Resultados
Se ha determinado el límite de detección, el límite de cuantificación y rango de medición para las 56 moléculas seleccionadas y se han comparado los resultados de once casos con las extracciones e instrumentación tradicionales.

Conclusiones
La metodología propuesta de preparación de muestras en sangre y análisis mediante técnicas más sensibles como LC-Q-q-LIT ha resultado comparable a la metodología tradicional en cuanto a resultados y, ofreciendo, además, una reducción de tiempo y coste.