bluuebunny/crossref_metadata_2025_split huggingface dataset:
Factors Associated With Decision to Use and Dosing of Sugammadex in Children: A Retrospective Cross-Sectional Observational Study
Authors: Brown Sydney E.S. , Mentz Graciela , Cassidy Ruth , Wade Meridith , Liu Xinyue , Zhong Wenjun , DiBello Julia , Nause-Osthoff Rebecca , Kheterpal Sachin , Colquhoun Douglas A. ,   the Multicenter Outcomes Group (MPOG) Perioperative Clinical Research Committee
Published: January 2024

BACKGROUND:
Sugammadex was initially approved for reversal of neuromuscular blockade in adults in the United States in 2015. Limited data suggest sugammadex is widely used in pediatric anesthesia practice however the factors influencing use are not known. We explore patient, surgical, and institutional factors associated with the decision to use sugammadex versus neostigmine or no reversal, and the decision to use 2 mg/kg vs 4 mg/kg dosing.

METHODS:
Using data from the Multicenter Perioperative Outcomes Group (MPOG) database, an EHR-derived registry, we conducted a retrospective cross-sectional study. Eligible cases were performed between January 1, 2016 and December 31, 2020, for children 0 to 17 years at US hospitals. Cases involved general anesthesia with endotracheal intubation and administration of rocuronium or vecuronium. Using generalized linear mixed models with institution and anesthesiologist-specific random intercepts, we measured the importance of a variety of patient, clinician, institution, anesthetic, and surgical risk factors in the decision to use sugammadex versus neostigmine, and the decision to use a 2 mg/kg vs 4 mg/kg dose. We then used intraclass correlation statistics to evaluate the proportion of variance contributed by institution and anesthesiologist specifically.

RESULTS:
There were 97,654 eligible anesthetics across 30 institutions. Of these 47.1% received sugammadex, 43.1% received neostigmine, and 9.8% received no reversal agent. Variability in the choice to use sugammadex was attributable primarily to institution (40.4%) and attending anesthesiologist (27.1%). Factors associated with sugammadex use (compared to neostigmine) include time from first institutional use of sugammadex (odds ratio [OR], 1.08, 95% confidence interval [CI], 1.08–1.09, per month, P < .001), younger patient age groups (0–27 days OR, 2.59 [2.00–3.34], P < .001; 28 days–1 year OR, 2.72 [2.16–3.43], P < .001 vs 12–17 years), increased American Society of Anesthesiologists [ASA] physical status (ASA III: OR, 1.32 [1.23–1.42], P < .001 ASA IV OR, 1.71 [1.46–2.00], P < .001 vs ASA I), neuromuscular disease (OR, 1.14 (1.04–1.26], P = .006), cardiac surgery (OR, 1.76 [1.40–2.22], P < .001), dose of neuromuscular blockade within the hour before reversal (>2 ED95s/kg OR, 4.58 (4.14–5.07], P < .001 vs none), and shorter case duration (case duration <60 minutes OR, 2.06 [1.75–2.43], P < .001 vs >300 minutes).

CONCLUSIONS:
Variation in sugammadex use was primarily explained by institution and attending anesthesiologist. Patient factors associated with the decision to use sugammadex included younger age, higher doses of neuromuscular blocking agents, and increased medical complexity.
Platelet-rich plasma therapy in the treatment of androgenic alopecia – review
Authors: Getka Beata , Przyborowska Kinga , Rukat Mateusz , Łata Michał , Kwiecień Justyna , Wiejak Katarzyna 
Published: January 2024

Hair loss is a problem that affects many people around the world. Androgenic alopecia (AGA) is the most common cause of hair loss affecting up to 50% of men and 40% of women over the age of 50. This type of hair loss is mediated by androgens, the strongest of which is dihydrotestosterone (DHT). This hormone influences the weakening hair follicles. The problem of excess DHT and the associated androgenic hair loss may concern people practicing sports, especially aerobic disciplines of moderate and high intensity. In the recent decades, many topical and oral therapies have been introduced to delay and stop hair loss. However, commonly used medications have only a partial and temporary effect, therefore alternative treatment methods are needed. Platelet-rich plasma (PRP) is known, among other things, for its use in orthopedics. The use of PRP may benefit athletes in the treatment of injuries to tendons, ligaments, muscles and cartilage. Many publications indicate good results with the use of PRP in the treatment of hair loss.
The aim of this study is to summarise the published reports on the effect of platelet-rich plasma (PRP) on hair loss prevention in people with androgenic alopecia (AGA) and to analyse the papers discussing androgen levels in physically active people.
Big Fish in Small Ponds: Human Capital Migration and the Rise of Boutique Banks
Authors: Gao Janet , Wang Wenyu , Yu Xiaoyun 
Published: January 2024

We study the comparative advantage of firms with focused and multidivisional organizational forms at attracting valuable human capital. Using the merger and acquisition (M&A) advisory industry as a laboratory, we show that high-performing individuals are more likely to migrate to boutique (focused) banks, especially those who are still on the upward trajectory of their career. Such migration is amplified by the cross-subsidization inside bulge bracket (multidivisional) firms, proxied by poor performance of their non-M&A departments. The transition of skilled labor improves the performance of the boutique sector, potentially contributing to the rise of boutiques over the past two decades. Moreover, M&A deal outcomes differ when having boutique advisors. Our findings suggest that corporate organizational structure and labor migration can jointly shape industry dynamics. This paper was accepted by Victoria Ivashina, finance. Funding: W. Wang gratefully acknowledges financial support from the Daniel C. Smith Fellowship. Supplemental Material: Data and the internet appendix are available at https://doi.org/10.1287/mnsc.2021.03829 .
Trust-and-Evaluate: A Dynamic Nonmonetary Mechanism for Internal Capital Allocation
Authors: Gupta Shivam , Bansal Saurabh , Dawande Milind , Janakiraman Ganesh 
Published: January 2024

To stay competitive, firms regularly invest in innovation by supporting internal capital projects (funded and executed in-house) that explore new products and operational improvements. Each year, in a highly competitive process, managers from different functional units of the firm submit proposals (that include estimated costs and benefits) for such projects. Managers, because of their domain knowledge and expertise, are naturally better informed about the costs and benefits of their respective projects and can use this information strategically to secure funding. An example of such behavior is the under-reporting of the cost estimate of a project and subsequently requesting additional funding during the execution phase. Such strategic behavior not only affects the firm’s ability to fund the best projects but is also costly. Motivated by this challenge of deciding the funding of such projects at a global agribusiness firm, we seek a mechanism that is both provably near-optimal for the firm and guarantees truthful reporting from managers. Our setting consists of a principal and multiple agents. In each time period, over an infinite horizon, each agent requests funding for a potential project from the principal. Before submitting his proposal, each agent privately estimates the project’s cost and its benefit. If funded, each project is executed in one period. The principal’s funding decisions are binary; that is, each project is either funded in full or not funded. The actual cost (benefit) of a funded project is realized on its completion and incurred (earned) by the principal. The agents earn utility from the experience and reputation gained in completing projects. In each period, the principal desires to keep the total spend below a budget but can borrow external money at a cost. Our main contribution is a practically appealing dynamic nonmonetary mechanism for internal capital allocation under which, for any [Formula: see text], (a) truth-telling forms an ϵ-Bayesian Nash equilibrium and (b) the principal’s expected utility is within ϵ of the expected utility in the first-best setting. This paper was accepted by Karan Girotra, operations management. Supplemental Material: The online appendices and data files are available at https://doi.org/10.1287/mnsc.2022.01121 .
3D surgical planning including patient-specific drilling guides for tibial plateau fractures
Authors: Assink Nick , ten Duis Kaj , de Vries Jean-Paul P. M. , Witjes Max J. H. , Kraeima Joep , Doornberg Job N. , IJpma Frank F. A. 
Published: January 2024

AimsProper preoperative planning benefits fracture reduction, fixation, and stability in tibial plateau fracture surgery. We developed and clinically implemented a novel workflow for 3D surgical planning including patient-specific drilling guides in tibial plateau fracture surgery.MethodsA prospective feasibility study was performed in which consecutive tibial plateau fracture patients were treated with 3D surgical planning, including patient-specific drilling guides applied to standard off-the-shelf plates. A postoperative CT scan was obtained to assess whether the screw directions, screw lengths, and plate position were performed according the preoperative planning. Quality of the fracture reduction was assessed by measuring residual intra-articular incongruence (maximum gap and step-off) and compared to a historical matched control group.ResultsA total of 15 patients were treated with 3D surgical planning in which 83 screws were placed by using drilling guides. The median deviation of the achieved screw trajectory from the planned trajectory was 3.4° (interquartile range (IQR) 2.5 to 5.4) and the difference in entry points (i.e. plate position) was 3.0 mm (IQR 2.0 to 5.5) compared to the 3D preoperative planning. The length of 72 screws (86.7%) were according to the planning. Compared to the historical cohort, 3D-guided surgery showed an improved surgical reduction in terms of median gap (3.1 vs 4.7 mm; p = 0.126) and step-off (2.9 vs 4.0 mm; p = 0.026).ConclusionThe use of 3D surgical planning including drilling guides was feasible, and facilitated accurate screw directions, screw lengths, and plate positioning. Moreover, the personalized approach improved fracture reduction as compared to a historical cohort.Cite this article: Bone Jt Open 2024;5(1):46–52.
Knowledge domains and emerging trends of Genome-wide association studies in Alzheimer’s disease: A bibliometric analysis and visualization study from 2002 to 2022
Authors: Kong Fanjing , Wu Tianyu , Dai Jingyi , Cai Jie , Zhai Zhenwei , Zhu Zhishan , Xu Ying , Sun Tao 
Published: January 2024

Objectives
Alzheimer’s disease (AD) is a neurodegenerative disorder characterized by a progressive decline in cognitive and behavioral function. Studies have shown that genetic factors are one of the main causes of AD risk. genome-wide association study (GWAS), as a novel and effective tool for studying the genetic risk of diseases, has attracted attention from researchers in recent years and a large number of studies have been conducted. This study aims to summarize the literature on GWAS in AD by bibliometric methods, analyze the current status, research hotspots and future trends in this field.

Methods
We retrieved articles on GWAS in AD published between 2002 and 2022 from Web of Science. CiteSpace and VOSviewer software were applied to analyze the articles for the number of articles published, countries/regions and institutions of publication, authors and cited authors, highly cited literature, and research hotspots.

Results
We retrieved a total of 2,751 articles. The United States had the highest number of publications in this field, and Columbia University was the institution with the most published articles. The identification of AD-related susceptibility genes and their effects on AD is one of the current research hotspots. Numerous risk genes have been identified, among which APOE, CLU, CD2AP, CD33, EPHA1, PICALM, CR1, ABCA7 and TREM2 are the current genes of interest. In addition, risk prediction for AD and research on other related diseases are also popular research directions in this field.

Conclusion
This study conducted a comprehensive analysis of GWAS in AD and identified the current research hotspots and research trends. In addition, we also pointed out the shortcomings of current research and suggested future research directions. This study can provide researchers with information about the knowledge structure and emerging trends in the field of GWAS in AD and provide guidance for future research.
Association of ABO blood group, Rh phenotype and MN blood group with susceptibility to COVID-19
Authors: Lu Genjie , Chen Wei , Lu Yangfang , Yu Qilin , Gao Li , Xin Shijun , Zhou Guanbao 
Published: January 2024

Background
Previous studies have reported that the susceptibility to coronavirus disease 2019 (COVID-19) is related to ABO blood group, but the relationship with Rh phenotype and MN blood group is unknown. China had adopted a strict control policy on COVID-19 until December 5, 2022, when local communities were liberalized. Therefore, we aimed to explore the correlation between ABO blood group, Rh phenotype, MN blood group and susceptibility to COVID-19 based on the time sequence of infection during the pandemic.

Methods
A total of 870 patients who were routinely hospitalized in Ningbo Medical Center Lihuili Hospital from March 1, 2023 to March 31, 2023 were randomly selected to enroll in this study. Patients were divided into susceptible group and non-susceptible group, according to the time of their previous infection. The demographics and clinical information of the enrolled participants were collected from electronic medical records. The association of ABO blood group, Rh phenotype and MN blood group with susceptibility to COVID-19 was analyzed.

Results
A total of 650 cases (74.7%) had been infected with COVID-19, with 157 cases (18.0%) in the second week and 252 cases (29.0%) in the third week, reaching the peak of infection. Compared with the non-susceptible group, the susceptible group had no statistically significant differences in ABO blood group and Rh phenotype, but the proportion of N+ was higher (75.6% vs 68.9%, P = 0.030) and the proportion of MM was lower (24.4% vs 31.1%, P = 0.030). Consistent with this, ABO blood group and Rh phenotype were not significantly associated with susceptibility to COVID-19 (P>0.05), while N+ and MM were associated with susceptibility to COVID-19 (OR: 1.432, 95% confidence interval [CI]: 1.049, 1.954, P = 0.024; OR: 0.698, 95% CI: 0.512, 0.953, P = 0.024, respectively), after adjusting for age, sex, BMI, basic disease, and vaccination status in multivariate logistic regression analysis.

Conclusion
Our study showed that ABO blood group and Rh phenotype may not be related to the susceptibility to COVID-19, but MN blood group may be associated with the susceptibility to COVID-19.
Effects of Bafa Wubu and He-Style Tai Chi exercise training on physical fitness of overweight male university students: A randomized controlled trial
Authors: Niu Yantao , Buranarugsa Rojapon , Kuhirunyaratn Piyathida 
Published: January 2024

This study aimed to compare the effects of 12-week Bafa Wubu Tai Chi (BW-TC) and traditional He-style Tai Chi (TH-TC) exercise training on physical fitness parameters in overweight university students and to compare the differences in their effects. A total of 81 overweight male university students were randomly assigned to the BW-TC group (N = 27), the TH-TC group (N = 27), and the control group (CG, N = 27). Upper limb grip strength, wall squat, sitting and reaching, 6-minute walk, single-leg stance, and Y-balance were measured at baseline and after 12 weeks of Tai Chi training. There were no significant differences in demographic characteristics and assessment parameters among the groups at baseline (p>0.05). Both BW-TC and TH-TC performed Tai Chi exercise program training lasting 12 weeks, with three sessions per week, each lasting 60 minutes intervention. The changes in mean scores for the sit-and-reach test were 3.11 cm and 4.52 cm, for the wall squat test were 27.56 s and 36.85 s, and for the 6-minute walk test were 22.93 m and 63.22 m, and Y-balance (p<0.05) significantly increased in both BW-TC and TH-TC groups, while the mean score of single-leg stance significantly decreased (p<0.05). Additionally, compared to the BW-TC group, the TH-TC group showed a significant increase in lower limb strength (13.89 s, p = 0.048) and the distance of the Y-balance test in the left posterior medial direction (4.04 cm, p = 0.031). BW-TC and TH-TC interventions effectively improved physical fitness in overweight university students. However, TH-TC showed superior results in lower limb strength improvement.
Trial registration number: ChiCTR2200059427 (https://www.chictr.org.cn).
Incidence, pathogens and antimicrobial resistance of blood and cerebrospinal fluid isolates from a tertiary neonatal unit in South Africa: A 10 year retrospective review
Authors: Thomas Reenu , Ondongo-Ezhet Claude , Motsoaledi Nini , Sharland Mike , Clements Michelle , Velaphi Sithembiso 
Published: January 2024

Objective
To determine trends in incidence, etiology and antimicrobial susceptibility of blood and cerebrospinal fluid (CSF) culture confirmed infections in hospitalized infants in a large tertiary neonatal unit in South Africa.

Methods
Single-center, retrospective review of laboratory records of bacteria and fungi, and their susceptibility profiles, isolated from blood and CSF of infants hospitalized in the neonatal unit at Chris Hani Baragwanath Academic Hospital, Johannesburg, South Africa, from 1st January 2010 to 31st December 2019. Laboratory data on isolates and their antimicrobial susceptibilities were collected. Coagulase-negative Staphylococcus, Corynebacteria and Bacillus spp. were excluded. Patient-level clinical and laboratory data were not available.

Results
There were 8,319 significant isolates, giving an infection rate of 14.3/1000 patient-days. Infection rates increased from 12.0 to 15.7/1000 patient-days (estimated average yearly change 0.6[95%CI, 0.5–0.7];p = <0.001). Gram-negative infection rates increased from 4.3 to 10.8/1000 patient-days (estimated average yearly change 0.7[95%CI,0.6–0.8];p = <0.001). The 2 most commonly isolated Gram-negative organisms were Acinetobacter baumannii (44%) and Klebsiella pneumoniae (39%). Carbapenem resistance was seen in 31% of all Gram-negatives and increased over time (estimated average yearly change 4.8%[95%CI,4.2%-5.3%];p<0.001). Gram-positive infection rates decreased (estimated average yearly change -0.1[95%CI,-0.2– -0.05];p = <0.001). Staphylococcus aureus was the most common Gram-positive isolated. Rates of methicillin-resistant Staphylococcus aureus decreased from 91% to 55%(estimated average yearly change -2.8%[95%CI,-3.5%–2%],p< 0.001). Rates of fungal isolates decreased (estimated average yearly change -0.06[95%CI,-0.1 –-0.02]);p = 0.007). Candida parapsilosis (52%) and Candida albicans (35%) were the most common fungi isolated.

Conclusions
There has been a marked overall increase in rates of blood and/or CSF infections, with an absolute increase in Gram-negative infections observed, replacing Gram-positive and fungal pathogens. Extended spectrum beta-lactamase Gram-negative isolates are being replaced by carbapenem resistance, with around one third of all significant Gram-negative isolates now carbapenem resistant. Research into hospital based novel treatment and prevention interventions for neonatal sepsis should be urgently prioritized.
A Novel Score Based on Controlled Attenuation Parameter Accurately Predicts Hepatic Steatosis in Individuals With Metabolic Dysfunction Associated Steatotic Liver Disease: A Derivation and Independent Validation Study
Authors: An Zi-Ming , Liu Qiao-Hong , Ye Xin-Jian , Zhang Qian , Pei Hua-Fu , Xin Xin , Yuan Jie , Huang Qian , Liu Kun , Lu Fang , Yan Zhi-Han , Zhao Yu , Hu Yi-Yang , Zheng Ming-Hua , Feng Qin 
Published: January 2024

INTRODUCTION:
In metabolic dysfunction–associated steatotic liver disease, the diagnostic efficacy of controlled attenuation parameter (CAP) was not very accurate in evaluating liver fat content. The aim of this study was to develop a score, based on CAP and conventional clinical parameters, to improve the diagnostic performance of CAP regarding liver fat content.

METHODS:
A total of 373 participants from 2 independent Chinese cohorts were included and divided into derivation (n = 191), internal validation (n = 75), and external validation (n = 107) cohorts. Based on the significant difference index between the 2 groups defined by the magnetic resonance imaging–proton density fat fraction (MRI-PDFF) in derivation cohort, the optimal model (CAP-BMI-AST score [CBST]) was screened by the number of parameters and the area under the receiver operating characteristic curve (AUROC). In the internal and external validation cohorts, the AUROC and corresponding 95% confidence intervals (CIs) were used to compare the diagnostic performance of CBST with that of CAP.

RESULTS:
We constructed the CBST = −14.27962 + 0.05431 × CAP − 0.14266 × body mass index + 0.01715 × aspartate aminotransferase. When MRI-PDFF was ≥20%, ≥10%, and ≥5%, the AUROC for CBST was 0.77 (95% CI 0.70–0.83), 0.89 (95% CI 0.83–0.94), and 0.93 (95% CI 0.88–0.98), which was higher than that for CAP respectively. In the internal validation cohort, the AUROC for CBST was 0.80 (95% CI 0.70–0.90), 0.95 (95% CI 0.91–1.00), and 0.98 (95% CI 0.94–1.00). The optimal thresholds of CBST were −0.5345, −1.7404, and −1.9959 for detecting MRI-PDFF ≥20%, ≥10%, and ≥5%, respectively.

DISCUSSION:
The CBST score can accurately evaluate liver steatosis and is superior to the CAP.
Wideband Antennas of Passive Seekers for Anti Radiation Missiles
Authors: Gupta Amit Kumar , Jain Tapan Kumar , Kothari Ashwin G , Chakravarthy Mada 
Published: January 2024

Suppression of Enemy Air Defence (SEAD) is a fundamental element of Air Power application by means of in protecting friendly air attackers and destroying the enemy’s ability to defend against air attack. Most of the SEAD operation even today relies on Anti-radiation missile (ARM) which is an air-to-surface tactical missile designed to detect, seek, attack and destroy opponent’s radar. Passive seeker of ARM is a miniaturized ESM receiver which is capable of extracting the necessary angular data from the enemy radar emissions. Single head passive seeker covering wide frequency range from L to Ku band is the preferred choice. Wideband antennas have been designed and utilized for Direction Finding applications of ESM/ELINT receivers for ground, air and ship borne platforms. Unlike these platforms, there are several restrictions for passive seeker based compact ESM receiver for missile borne platform specially air to surface missile where lesser diameter is one of the preferred design parameter. This review paper mainly discusses the existing wideband antennas such as spiral, log-periodic, printed circuit vivaldi and all-metal vivaldi antennas and the comparison of their various parameters for passive seeker. The paper also suggests their suitability with respect to their placement on the missile for three configurations: concealed inside the radome, flush-mounted and conformal antenna based. The paper also brought about the specific test facility required for testing and evaluation of passive seeker to characterize it with missile radome which is the most challenging and time consuming task. Among the three passive seeker configuration discussed, conformal antenna based passive seeker using all-metal Vivaldi is the best option avoiding radome aberration correction which is being utilized in the present third generations of ARM. The second commonly and established passive seeker configuration is concealed inside the radome using spiral antennas where handling radome aberration correction is a limitation.