bluuebunny/crossref_metadata_2025_split huggingface dataset:
Multicentre experience on the diagnostic yield of PCR testing for bacterial pathogens in sterile site infections
Authors: Hasan Mohammad Rubayet , Tang Patrick , Sharma Anju , Jayaratne Padman , Rutherford Candy , Sundararaju Sathyavathi , Suleiman Mohammed , Leto Daniela , Yamamura Deborah , Perez-Lopez Andres , Smieja Marek 
Published: January 2025

Background: Infections in sterile body sites are serious despite their low incidence. Accurate diagnosis is crucial for effective antimicrobial management. This study assesses the diagnostic yield of multiplex polymerase chain reaction (PCR) in identifying bacterial pathogens in sterile site specimens other than blood and CSF. Methods: Bacterial pathogen PCR panels were independently developed and validated by the laboratories at the Hamilton Regional Laboratory Medicine Program (HRLMP) in Canada and Sidra Medicine in Qatar. Retrospective culture and PCR data for the periods of July 2022 to November 2023 and September 2021 to February 2023 were extracted from the laboratory information systems of HRLMP and Sidra Medicine, respectively. The diagnostic yield of PCR between different groups was compared using the McNemar test or the chi-squared test. Results: Validation studies showed 100% sensitivity for PCR assays in both laboratories, with varying specificity due to the detection of additional pathogens by PCR. Combining post-implementation data from both laboratories, 38.7% of 512 specimens were PCR-positive for target organisms, compared to 6.1% by culture. While the diagnostic yield of PCR was significantly higher than that of culture in both adult and pediatric populations ( p < .001), HRLMP data indicated a significantly higher diagnostic yield of PCR in the pediatric population compared to adults (64.7% vs. 17.4%; p < .001). The most commonly PCR-detected pathogens were Streptococcus pneumoniae, Streptococcus pyogenes, and Staphylococcus aureus, with pleural fluid being the most frequently positive specimen type. Conclusion: The study supports using PCR alongside culture to enhance pathogen detection and improve the management of sterile site infections, particularly in pediatric patients.
POWERLIFTING TRAINING METHODS FOR WOMEN AGED 35–40 YEARS: ORGANIZATION AND STRUCTURE OF THE TRAINING PROCESS FOR ACHIEVING MAXIMUM SPORTS RESULTS
Authors: Hordiienko Oksana V. , Zhamardiy Valeriy O. , Horoshko Viktoriia I. , Danylchenko Svitlana I. , Novopysmennyi Anatolii M. 
Published: January 2025

Introduction. Powerlifting by women aged 35–40 years in the challenges of today and the realities of Ukraine is relevant, as it contributes to physical and psychological and social communication.
Aim. To conduct a comprehensive analysis of the factors impacting powerlifting on the health of women aged 35–40 years, to develop an author's method of training to achieve high sports results and prevent injuries. In this study, women aged 35–40 from the sports club "Olimp" and "Prometheus", Poltava, Ukraine, were involved.
Materials and methods. A group of powerlifting women aged 35–40 years was selected based on age, training experience, physical parameters. The collected data was analysed to determine the relationship between indicators of physical and psychological health, and to identify injury risk factors.
Results. Based on the results, an author's training method was developed, taking into account the peculiarities of the female body. Comparative analysis of the results was carried out with the control group. The training methodology developed on the basis of macrocycles and mesocycles of training, is an effective tool for preparing athletes for competitions with maximum sports results. The division of training into mesocycles with different durations and types of loads contributes to a gradual increase in results. The use of the technique allows to avoid overloads and injuries, provides control of cardiovascular activity and timely prevention of overtraining.
Conclusions. The methodology is flexible to the needs and capabilities of female athletes. Development prospects and scientific significance of the research: The current research in powerlifting don’t focus sufficiently on optimal training approaches, taking into account physiological and hormonal characteristics, as well as their impact on training efficiency and achieving maximum results. This study makes a significant contribution to the field of powerlifting in women aged 35–40, a new training program contributes to a significant improvement in results on all indicators by 21%. This study confirms the effectiveness of the developed program and can become a valuable basis for developing personalized training approaches and improving athletic performance in women of this age range.
Sustainability in the Hotel Sector: A Research Study in Greece
Authors: Vagena Akrivi 
Published: January 2025

Tourism is an essential economic sector in Greece, contributing over 25% to its GDP. The hotel sector is a significant component of the tourism industry, which plays also a vital role in the economy of Greece.

However, its environmental impact—manifesting through high energy usage, water consumption, and waste generation—poses significant challenges. This study explores sustainable practices within Greek hotels, emphasizing the adoption of circular economy principles, green certifications, and guest engagement strategies. Using case studies, published data from surveys, and policy analysis, the study identifies barriers such as financial limitations and infrastructural gaps. The methodology combines detailed analysis of five case studies, a survey of 200 hotel managers, and policy analysis to assess the barriers and opportunities for sustainability. Key barriers, such as financial constraints and infrastructural gaps, were identified through stakeholder surveys and policy evaluations. These obstacles significantly impact the sector's ability to implement green practices, particularly in energy-intensive operations and waste management.

Recommendations include financial incentives, region-specific policies, and advanced technological solutions. By addressing these barriers, the study aligns with global frameworks such as the United Nations Sustainable Development Goals (SDGs), specifically SDG 7 (Affordable and Clean Energy) and SDG 12 (Responsible Consumption and Production).

Key findings include the critical role of tailored regional policies, the impact of financial incentives on sustainability adoption, and the necessity for advanced technological solutions in addressing infrastructure deficiencies. These contributions underscore the transformative potential of embedding sustainability into the hotel sector and highlight Greece's potential to become a leader in global sustainable tourism.
PELAKSANAAN ZAKAT PROFESI BAGI APARATUR SIPIL NEGARA BERDASARKAN UNDANG-UNDANG NOMOR 23 TAHUN 2011 TENTANG PENGELOLAAN ZAKAT (Studi Kasus di Kantor BAZNAS Kabupaten Tulungagung)
Authors: Yuniati Anik , Fahrazi Mahfudz 
Published: January 2025

This study examines the Implementation of Professional Zakat for State Civil Servants Based on Law Number 23 of 2011 concerning Management of Zakat at the BAZNAS Office of Tulungagung Regency. The aims of this study are 1) to analyze the implementation of professional zakat by Tulungagung Regency BAZNAS towards the State Civil Apparatus based on Law Number 23 of 2011 concerning the management of zakat, 2) To analyze the inhibiting factors in the management of professional zakat for the State Civil Apparatus at BAZNAS Tulungagung Regency.The research method used in this research is empirical juridical research with a qualitative descriptive analytical approach. Data collection techniques were carried out by interviews, observation and documentation. The analysis technique used in this study is the syllogism method and interpretation using deductive thinking patterns. The research results show 1) the implementation of professional zakat by BAZNAS of Tulungagung Regency towards the State Civil Apparatus based on Law Number 23 of 2011 concerning the management of zakat is carried out by deducting employee salaries which are carried out every month by the treasurer.The employee salary deduction is only applied by employees of the State Civil Apparatus who earn above 3 million rupiah and are deducted from their gross monthly salary. Salary deducted by 2.5%, professional zakat from salary deductions entirely paid to BAZNAS Tulungagung Regency distributes it to 8 ashnaf. 2) The inhibiting factors in the management of professional zakat for the State Civil Apparatus at BAZNAS Tulungagung Regency include 1) The need for increased support from the government in the form of policies, 2) Lack of awareness of zakat through institutions, public awareness for zakat currently continues to increase, this is occursdue to a lack of trust in zakat institutions. 3) The need for increased funds for socialization.
Pengaruh Pemberian Reward dan Punishment Terhadap Kinerja Karyawan PT. Adam Kurnia Abadi
Authors: Adam Andi Muchammad Naufal , Warganegara Tri Lestira Putri 
Published: January 2025

Economic development and competing companies that increasingly require companies to develop Human Resources who are members of a company or organization. The provision of rewards and punishments in accordance with the behavior shown at work is one of the company's management efforts to get the best performance from its employees. All employees of PT. Adam Kurnia Abadi with a total of 50 employees involved in the study as respondents. The researcher proposed three hypotheses in this study and analyzed using multiple linear regression with the help of the SPSS Version 24 Program. Rewarding has a significant influence on employee performance, while the punishment system does not have a significant influence on employee performance. However, the provision of rewards and punishment systems that are given at the same time can have a positive and meaningful influence on the performance of PT. Adam Kurnia Abadi. Therefore, the more appropriate the reward and punishment system that can be given by the management, the performance of PT. Adam Kurnia Abadi will increase.
Keywords: Reward, Punishment, Kinerja Karyawan
Systemic Immune-inflammation Index: A Potential Indicator of Disease Activity in Sjögren's Syndrome?
Authors: Murat Doğan  , Songül Keskin Kavak  
Published: January 2025

Given the autoimmune and inflammatory nature of Sjögren's Syndrome(SS), it is essential to identify reliable indicators to monitor disease progression and inform treatment strategies. This study aims to evaluate the potential of the Systemic Immune-Inflammation Index (SII) as a biomarker for assessing disease activity in SS. A prospective analysis was conducted on two groups: the first comprising 52 patients diagnosed with SS and the second a healthy control group. SII values were calculated using the following formula: platelet count multiplied by the neutrophil-to-lymphocyte ratio. The degree of disease activity was gauged according to the EULAR Sjögren's Syndrome Disease Activity Index (ESSDAI) criteria. This study examines the correlations between SII and several clinical and patient-reported outcome measures, including various inflammatory markers. Compared to the control group, the SS patient cohort displayed slightly elevated SII levels (p = 0.04). The SII exhibited a correlation with elevated levels of C-reactive protein (CRP) and erythrocyte sedimentation rate (ESR), suggesting its potential as a marker of systemic inflammation. Nevertheless, the observed correlation between SII and ESSDAI scores (r = 0.0903) was weak and not statistically significant (p = 0.524). Although SII values were higher in SS patients and correlated with systemic inflammation markers, no statistically significant relationship was observed between these values and disease activity, as measured by ESSDAI.Thus, while SII may reflect systemic inflammation, its utility as a marker for disease activity in SS remains limited. Further studies are needed to elucidate its role in clinical settings.
Breaking Barriers in-Vivo THz Communication Analysis for Nano Networks in Human Tissues
Authors: Asi Ban A. , Mahmood Farhad E. , Najim Nada I. 
Published: January 2025

Body Nano-Communication based on RF radio communication in the terahertz band supports health and fitness industry applications. Nano communications primary facilitate real-time monitoring of biological and chemical substances inside the human body, helping an early detection of stroke and heart attack risks. Monitoring small communication range inside the human body via electromagnetic propagation is not an easy task; thus, in this paper, we investigate the path loss of radio propagation in three human tissues: blood, skin, and fat using a Tera-Hertz frequency range in between 0.5 and 1.5 THz. The results support the idea that the path loss inside the human body depends on the dielectric loss of human tissues and the function of frequency and distance. It also shows that increasing the distance and the frequency of the signal inside the tissues, such as blood, fat, and skin, the path loss increases because the attenuation increases when the frequency increases. Furthermore, the study examines the effect of Doppler as a method of measuring the speed of blood flow to predict the early risks being considered.
Analisis Stabilitas Dinding Penahan Tanah Tipe Kantilever, Gravitasi, dan Sheet Pile
Authors: Febrijanto Rudy , Zhafirah Athaya , Rohadatul Aisy A Aam 
Published: January 2025

Permukaan bumi memiliki bentuk yang tidak rata atau membentuk kemiringan sehingga terjadi perbedaan elevasi muka tanah. Perbedaan elevasi muka tanah memiliki potensi terjadinya longsor. Dinding penahan tanah menjadi salah satu alternatif untuk mengatasi longsor. Tujuan dari penelitian ini menghasilkan desain dinding penahan tanah untuk menangani permasalahan longsor yang terjadi di Ruas Jalan Singajaya-Toblong (Blok Liang Kerud). Metode penelitian yang digunakan adalah analisis kestabilan dinding penahan tanah dengan metode rankine dan metode elemen hingga. Jenis dinding penahan tanah yang dipakai dalam penelitian ini antara lain, tipe gravitasi, kantilever, dan sheet pile. Hasil penelitian menunjukkan bahwa desain dinding penahan tanah tipe kantilever tidak aman karena nilai stabilitas geser yang tidak memenuhi persyaratan yaitu 0,742 < 1,5. Hasil analisis dinding penahan tanah tipe gravitasi paling aman terhadap kestabilan tanah dilihat dari nilai faktor keamanan 1,53 > 1,5; nilai stabilitas guling 2 â‰¥ 2; dan nilai stabilitas geser 4,642 > 1,5. Sementara itu, tipe sheet pile yang memperhitungkan seberapa panjang material baja yang dibutuhkan tetap tidak bisa menahan tanah. Kesimpulan penelitian ini menunjukkan bahwa dinding penahan tanah yang paling aman yaitu tipe gravitasi yang memiliki nilai faktor aman terhadap stabilitas guling dan stabilitas geser yang melebihi persyaratan kestabilan tanah.
Pengaruh Pelatihan Motivasi Kerja terhadap Kinerja Perawat Pelaksana dalam Memberikan Asuhan Keperawatan di RS Husada Jakarta
Authors: Saragih Dameria 
Published: January 2025

Pelayanan keperawatan yang merupakan salah satu tugas dan tanggung jawab perawat adalah memberikan asuhan keperawatan. Tujuan penelitian ini untuk menganalisis pengaruh pelatihan motivasi kerja terhadap kinerja perawat pelaksana dan menganalisis pengaruh karakteristik individu terhadap kinerja perawat pelaksana di Rumah Sakit Husada Jakarta. Rancangan penelitian Quasi Eksperimental dengan Pre-Post Test Group Design. Responden pada kelompok intervensi sebanyak 27 responden yang dipilih dengan teknik purposive sampling. Responden pada kelompok kontrol sebanyak 27 orang. Responden pada kelompok intervensi diberikan pelatihan motivasi serta pengawasan dan pengamatan selama 4 minggu. Pengumpulan data menggunakan kuesioner dan lembar observasi penilaian kinerja kerja kemudian dianalisis bivariate dengan uji paired sampel t-test dan multivariate dengan uji ancova. Hasil penelitian menunjukkan ada pengaruh Kinerja terhadap pelatihan motivasi serta variabel counfonding didapatkan hasil Corrected Model 0,000. Sedangkan secara parsial didapatkan lama kerja 0,000 dan pelatihan motivasi 0,009. Pelatihan motivasi dan lama kerja mempengaruhi kinerja kerja sebanyak 46,6%. Peneliti merekomendasikan pelatihan motivasi dalam peningkatan kinerja kerja dalam memberikan asuhan keperawatan.
Towards quantifying exfiltration from in situ sanitary sewer pipes
Authors: Griffith John F. , Steele Joshua A. , Gonzalez-Fernández Adriana , Schiff Kenneth C. 
Published: January 2025

Exfiltration from sanitary sewers has been researched for many years because of its potential impact on shallow groundwater or surface water, but measurements of exfiltration in situ are rare. Most previous measurements of sanitary sewer exfiltration have been done in the laboratory, in the field using natural, chemical or pharmaceutical tracers or modeled. Relatively few studies have employed physical measurements of volume loss in field settings. Here, we design, test, and apply at a watershed scale, a new methodology for measuring volume loss from sanitary sewer pipes that are currently in use and under typical operating conditions (i.e., not pressurized). The measurement system works by: (1) isolating a section of sanitary sewer between maintenance holes using a sewer bypass or equivalent, (2) introducing roughly 4,200 L of water at a controlled rate into the upstream inspection hole so that pipes remain one-third to one-half full, (3) using vacuum pumps to recover the introduced water at the downstream inspection hole, then (4) measuring differences in the volume from what was pumped into the inspection hole to what was recovered. This process is repeated up to six times to achieve a sensitivity of 0.95 L per experimental pipe segment. This technique was applied to 23 pipe segments of various ages and materials of construction that were selected to be a representative sample of the pipes throughout San Diego. Collectively, these pipes averaged averaged 3.78 × 10−2 L/s-km exfiltration rates (95%CI: 4.96 × 10−2, 2.60 × 10−2). Two of the pipe segments were infiltrating groundwater. Six pipe segments were not statistically different from zero (i.e., no exfiltration). There was no statistical difference between pipe segments of differing ages (p = 0.5) or materials of construction (p = 0.3). This study represents an initial effort at measuring exfiltration from in situ sanitary pipes. Future applications of this methodology should focus on method optimization, measurements at additional locations, and expanding measurements to collect data from additional types of pipe to better understand the geographic portability of the method and the relationship between exfiltration rates, pipe material, and pipe age.
Identification and validation of glycolysis-related diagnostic signatures in diabetic nephropathy: a study based on integrative machine learning and single-cell sequence
Authors: Wu Xiaoyin , Guo Buyu , Chang Xingyu , Yang Yuxuan , Liu Qianqian , Liu Jiahui , Yang Yichen , Zhang Kang , Ma Yumei , Fu Songbo 
Published: January 2025

BackgroundDiabetic nephropathy (DN) is a complication of systemic microvascular disease in diabetes mellitus. Abnormal glycolysis has emerged as a potential factor for chronic renal dysfunction in DN. The current lack of reliable predictive biomarkers hinders early diagnosis and personalized therapy.MethodsTranscriptomic profiles of DN samples and controls were extracted from GEO databases. Differentially expressed genes (DEGs) and their functional enrichments were identified. Glycolysis-related genes (GRGs) were selected by combining DEGs, weighted gene co-expression network, and glycolysis candidate genes. We established a diagnostic signature termed GScore via integrative machine learning framework. The diagnostic efficacy was evaluated by decision curve and calibration curve. Single-cell RNA sequence data was used to identify cell subtypes and interactive signals. The cMAP database was used to find potential therapeutic agents targeting GScore for DN. The expression levels of diagnostic signatures were verified in vitro.ResultsThrough the 108 combinations of machine learning algorithms, we selected 12 diagnostic signatures, including CD163, CYBB, ELF3, FCN1, PROM1, GPR65, LCN2, LTF, S100A4, SOX4, TGFB1 and TNFAIP8. Based on them, an integrative model named GScore was established for predicting DN onset and stratifying clinical risk. We observed distinct biological characteristics and immunological microenvironment states between the high-risk and low-risk groups. GScore was significantly associated with neutrophils and non-classical monocytes. Potential agents including esmolol, estradiol, ganciclovir, and felbamate, targeting the 12 diagnostic signatures were identified. In vitro, ELF3, LCN2 and CD163 were induced in high glucose-induced HK-2 cell lines.ConclusionAn integrative machine learning frame established a novel diagnostic signature using glycolysis-related genes. This study provides a new direction for the early diagnosis and treatment of DN.
Herbal HuoXueTongFu Formula with anti-inflammatory and fibrinolytic activity regulation for the prevention of postoperative peritoneal adhesions
Authors: Yang Lili , Wang Yali , Li Zhengjun , Li Wen , Chen Yanqi , Kong Ziyang , Zhang Huixiang , Wu Jiafei , Shang Mingqi , Li Ming , Bian Yaoyao , Zeng Li 
Published: January 2025

BackgroundThe HuoXueTongFu Formula (HXTF) originates from the classic prescription “DaHuangMuDan Decoction” from the “Synopsis of the golden chamber”. Our previous study revealed that HXTF has a positive effect on postoperative peritoneal adhesion (PPA). However, the specific mechanism of HXTF on PPA formation within the time-to-treatment window has not been fully elucidated. This study aimed to determine the critical roles of HXTF as a result of its specific anti-inflammatory and antifibrinolytic activities for PPA treatment.MethodsThe eight main bioactive components of HXTF were subjected to high-performance liquid chromatography-mass spectrometry. The core targets, critical biological processes, and underlying pathways of HXTF and PPA were identified via a series of network pharmacological methods. The specific anti-inflammatory function in the initial step of PPA formation was validated in peritoneal macrophages (PMs) isolated from PPA mice on Day 3 postsurgery. The potential anti-fibrinolytic activity in the next stage of PPA formation was subsequently explored in PPA mice on Day 7 postsurgery.ResultsNetwork pharmacology revealed 160 common targets between HXTF and PPA. Several core targets, i.e., matrix metalloproteinase 9 (MMP9), tissue-type plasminogen activator (tPA), and plasminogen activator inhibitor 1 (PAI-1), were annotated as important biological processes (extracellular matrix disassembly and the collagen catabolic process). Validation experiments revealed that HXTF could induce macrophage polarization-mediated anti-inflammatory reactions by increasing the phagocytic capacity of PMs and promoting the release of anti-inflammatory cytokines (IL-4 and IL-10). In addition, HXTF promoted fibrinogenolysis and improved fibrinolytic activity, thereby inhibiting collagen deposition and reducing adhesion development.ConclusionThe ameliorative effects of herbal HXTF on PPA formation are attributable to the induction of macrophage polarization-mediated anti-inflammatory reactions in the early stage of PPA formation and the promotion of fibrinogenolysis and fibrinolytic activity in the middle stage of PPA formation. HXTF may be a promising alternative agent for the prevention and treatment of PPA.