bluuebunny/crossref_metadata_2025_split huggingface dataset:
A bifactor representation of the Center for Epidemiological Studies Depression Scale for children: gender and age invariance and implications for adolescents’ social and academic adjustment
Authors: Zhao Yanhua , Niu Jiahui , Huang Jing , Meng Yan 
Published: February 2024

Abstract
Background
The Center for Epidemiological Studies Depression Scale for Children (CES-DC) is a widely used scale for screening depressive symptoms in children and adolescents. This study aims to uncover the optimal factor structure of the DES-DC and presents an alternate conceptualization of adolescent depression by estimating bifactor models and several competing models using a sample of Chinese adolescents.

Methods
The participants were 533 adolescents (49.7% boys, 49.7% girls, 3 participants did not report) between 12 and 18 years of age attending public secondary schools in the middle part of mainland China. Data were collected in classrooms using a questionnaire survey. A structural equation modeling approach was used to estimate and compare a series of competing models for the DES-DC.

Results
A Bifactor exploratory structural equation model (Bi-ESEM) with the best model fit was retained for representing the current data. Tests of measurement invariance demonstrated strict measurement equivalence across gender and age. No gender and age differences have been found in the general depression factor. Findings provided evidence for the composite reliability and construct validity of DES-DC. Depressive symptoms positively related to the Big Five trait neuroticism, negative emotions, loneliness, social anxious behaviors, and disruptive behaviors during school and negatively related to agreeableness, conscientiousness, extraversion, physical health status, school connectedness, and academic self-efficacy.

Conclusions
This study provides support for the one general factor construct of the CES-DC and the continuum concept structure of adolescent depression. Moreover, this research offers empirical evidence for comparing depression symptoms among adolescent populations with diverse genders and age groups. Additionally, the findings replicate and expand upon the implications of depressive symptoms on adolescents’ traits, well-being, social-relational adjustment, and academic adaptation.
The prostate-specific membrane antigen holds potential as a vascular target for endogenous radiotherapy with [177Lu]Lu-PSMA-I&T for triple-negative breast cancer
Authors: Heesch Amelie , Florea Alexandru , Maurer Jochen , Habib Pardes , Werth Laura S. , Hansen Thomas , Stickeler Elmar , Sahnoun Sabri E. M. , Mottaghy Felix M. , Morgenroth Agnieszka 
Published: February 2024

Abstract
Introduction
Overexpression of prostate-specific membrane antigen (PSMA) on the vasculature of triple-negative breast cancer (TNBC) presents a promising avenue for targeted endogenous radiotherapy with [177Lu]Lu-PSMA-I&T. This study aimed to assess and compare the therapeutic efficacy of a single dose with a fractionated dose of [177Lu]Lu-PSMA-I&T in an orthotopic model of TNBC.

Methods
Rj:NMRI-Foxn1nu/nu mice were used as recipients of MDA-MB-231 xenografts. The single dose group was treated with 1 × 60 ± 5 MBq dose of [177Lu]Lu-PSMA-I&T, while the fractionated dose group received 4 × a 15 ± 2 MBq dose of [177Lu]Lu-PSMA-I&T at 7 day intervals. The control group received 0.9% NaCl. Tumor progression was monitored using [18F]FDG-PET/CT. Ex vivo analysis encompassed immunostaining, TUNEL staining, H&E staining, microautoradiography, and autoradiography.

Results
Tumor volumes were significantly smaller in the single dose (p < 0.001) and fractionated dose (p < 0.001) groups. Tumor growth inhibition rates were 38% (single dose) and 30% (fractionated dose). Median survival was notably prolonged in the treated groups compared to the control groups (31d, 28d and 19d for single dose, fractionated dose and control, respectively). [177Lu]Lu-PSMA-I&T decreased the size of viable tumor areas. We further demonstrated, that [177Lu]Lu-PSMA-I&T binds specifically to the tumor-associated vasculature.

Conclusion
This study highlights the potential of [177Lu]Lu-PSMA-I&T for endogenous radiotherapy of TNBC.

Graphical abstract
DNA satellite and chromatin organization at mouse centromeres and pericentromeres
Authors: Packiaraj Jenika , Thakur Jitendra 
Published: February 2024

Abstract
Background
Centromeres are essential for faithful chromosome segregation during mitosis and meiosis. However, the organization of satellite DNA and chromatin at mouse centromeres and pericentromeres is poorly understood due to the challenges of assembling repetitive genomic regions.

Results
Using recently available PacBio long-read sequencing data from the C57BL/6 strain, we find that contrary to the previous reports of their homogeneous nature, both centromeric minor satellites and pericentromeric major satellites exhibit a high degree of variation in sequence and organization within and between arrays. While most arrays are continuous, a significant fraction is interspersed with non-satellite sequences, including transposable elements. Using chromatin immunoprecipitation sequencing (ChIP-seq), we find that the occupancy of CENP-A and H3K9me3 chromatin at centromeric and pericentric regions, respectively, is associated with increased sequence enrichment and homogeneity at these regions. The transposable elements at centromeric regions are not part of functional centromeres as they lack significant CENP-A enrichment. Furthermore, both CENP-A and H3K9me3 nucleosomes occupy minor and major satellites spanning centromeric-pericentric junctions and a low yet significant amount of CENP-A spreads locally at centromere junctions on both pericentric and telocentric sides. Finally, while H3K9me3 nucleosomes display a well-phased organization on major satellite arrays, CENP-A nucleosomes on minor satellite arrays are poorly phased. Interestingly, the homogeneous class of major satellites also phase CENP-A and H3K27me3 nucleosomes, indicating that the nucleosome phasing is an inherent property of homogeneous major satellites.

Conclusions
Our findings reveal that mouse centromeres and pericentromeres display a high diversity in satellite sequence, organization, and chromatin structure.
A mathematical model for evaluating the impact of nonpharmaceutical interventions on the early COVID-19 epidemic in the United Kingdom
Authors: Zhang Hongyu , Jing Shuanglin 
Published: February 2024

AbstractThe coronavirus disease 2019 (COVID-19) presents a severe and urgent threat to global health. In response to the COVID-19 pandemic, many countries have implemented nonpharmaceutical interventions (NPIs), including national workplace and school closures, personal protection, social distancing, contact tracing, testing, home quarantine, and isolation. To evaluate the effectiveness of these NPIs in mitigating the spread of early COVID-19 and predict the epidemic trend in the United Kingdom, we developed a compartmental model to mimic the transmission with time-varying transmission rate, contact rate, disease-induced mortality rate, proportion of quarantined close contacts, and hospitalization rate. The model was fitted to the number of confirmed new cases and daily number of deaths in five stages with a Markov Chain Monte Carlo method. We quantified the effectiveness of NPIs and found that if the transmission rate, contact rate, and hospitalization rate were approximately equal to those in the second stage of the most strict NPIs, and the proportion of quarantined close contacts increased by 3%, then the epidemic would die out as early as January 12, 2021, with around 1,533,000 final cumulative number of confirmed cases, and around 55,610 final cumulative number of deaths.
Development and validation of a nomogram to predict the risk of sepsis-associated encephalopathy for septic patients in PICU: a multicenter retrospective cohort study
Authors: Wang Guan , Jiang Xinzhu , Fu Yanan , Gao Yan , Jiang Qin , Guo Enyu , Huang Haoyang , Liu Xinjie 
Published: February 2024

Abstract
Background
Patients with sepsis-associated encephalopathy (SAE) have higher mortality rates and longer ICU stays. Predictors of SAE are yet to be identified. We aimed to establish an effective and simple-to-use nomogram for the individual prediction of SAE in patients with sepsis admitted to pediatric intensive care unit (PICU) in order to prevent early onset of SAE.

Methods
In this retrospective multicenter study, we screened 790 patients with sepsis admitted to the PICU of three hospitals in Shandong, China. Least absolute shrinkage and selection operator regression was used for variable selection and regularization in the training cohort. The selected variables were used to construct a nomogram to predict the risk of SAE in patients with sepsis in the PICU. The nomogram performance was assessed using discrimination and calibration.

Results
From January 2017 to May 2022, 613 patients with sepsis from three centers were eligible for inclusion in the final study. The training cohort consisted of 251 patients, and the two independent validation cohorts consisted of 193 and 169 patients. Overall, 237 (38.7%) patients developed SAE. The morbidity of SAE in patients with sepsis is associated with the respiratory rate, blood urea nitrogen, activated partial thromboplastin time, arterial partial pressure of carbon dioxide, and pediatric critical illness score. We generated a nomogram for the early identification of SAE in the training cohort (area under curve [AUC] 0.82, 95% confidence interval [CI] 0.76–0.88, sensitivity 65.6%, specificity 88.8%) and validation cohort (validation cohort 1: AUC 0.80, 95% CI 0.74–0.86, sensitivity 75.0%, specificity 74.3%; validation cohort 2: AUC 0.81, 95% CI 0.73–0.88, sensitivity 69.1%, specificity 83.3%). Calibration plots for the nomogram showed excellent agreement between SAE probabilities of the observed and predicted values. Decision curve analysis indicated that the nomogram conferred a high net clinical benefit.

Conclusions
The novel nomogram and online calculator showed performance in predicting the morbidity of SAE in patients with sepsis admitted to the PICU, thereby potentially assisting clinicians in the early detection and intervention of SAE.
Mesh-free kinematic shakedown analysis of cohesive soils
Authors: Nosrati Z. , Binesh S. M. 
Published: February 2024

AbstractA novel mesh-free solution is proposed for kinematic shakedown analysis of cohesive soils under repeating loads. For this purpose, the continuous velocity field in the mathematical expression of Koiter’s theorem is discretized by the Radial Point Interpolation Method (RPIM), as a mesh-free approach. The strain rate smoothing technique is implemented in conjunction with the RPIM to satisfy the admissibility conditions at the entire problem domain. Using the nodal integration and the discretized velocity field, the kinematic shakedown problem is expressed as a nonlinear optimization problem. The optimization problem is solved by separation of plastic and non-plastic/rigid zones using a repetitive algorithm. Eventually, the efficiency of the proposed approach is elucidated by solving examples of a strip footing resting on cohesive soil and a cohesive half space pavement under repeating loads.
Embodied spirituality: Shaolin martial arts as a Chan Buddhist practice
Authors: Nešković Marta 
Published: February 2024

AbstractThis paper explores the intersection of spirituality and martial arts through an in-depth examination of Shaolin Kung Fu as practiced within the Shaolin Monastery in Henan Province, China. Conducting fieldwork from April 2018 to August 2020, the study employs theories of practice and embodiment to understand how religious teachings are interwoven into physical movements and martial practices. This phenomenological analysis of bodily movement integrates the physical body with the sense of self, highlighting the relationship between individual habitus and the agency of the moving body, referred to as the “lived body.” It argues that Shaolin martial artists engage in a form of dynamic embodiment, where Chan Buddhist doctrines are embedded within the “lived body,” influencing both movement and perception. This process allows practitioners to interpret and interact with their socio-cultural environment through a religious lens, highlighting the deep connection between spiritual beliefs and bodily actions.The paper presents a comprehensive approach, combining intensive participant observation, historical analysis, and a close look at both the communal and individual aspects of monastic life and learning. By examining narratives, daily routines, and pedagogical methods, the study reveals how the socio-cultural setting of the monastery fosters collective habitus and transforms the individual habitus of practitioners. It shows how this transformation contributes to the development of a spiritual dimension in their martial performance. By highlighting the link between the habitus, the lived body, and the dynamic embodiment, the paper extends the current discourse on embodiment, offering a novel perspective on the relationship between spirituality, culture, and physical practice in the context of Shaolin Kung Fu.
Termite species and functional diversity as determined by vegetation and edaphic characteristics in a savanna ecosystem
Authors: Madonsela Zodwa , Magagula Cebisile N. 
Published: February 2024

Abstract
Background
Savanna ecosystems support a diversity of biota and are influenced by vegetation and edaphic characteristics, shaping resident communities. This study was carried out at Mlawula nature reserve, a protected savanna ecosystem to determine impacts of vegetation and edaphic characteristics on termite species and functional diversity, as well as their activity. Termites were sampled from November 2017 to March 2018 in two habitat types, i.e. encroached and non-encroached by Dichrostachys cinerea over five months.

Results
Twelve genera were collected over the study period, dominated by Microtermes sp. Termite species diversity and populations were significantly between habitat types, with higher numbers and species in non-encroached sites. Four functional groups (FG) were collected from both habitat types, with FGII being the most dominant group in both and no significant differences in FG diversity between the habitat types. Of the vegetational and edaphic variables measured, only canopy cover was significantly different between habitat types and was higher in encroached sites. Intensity and frequency of attack were significantly higher in non-encroached sites, indicating a decline in termite activity in encroached sites.

Conclusions
Results indicated that, with the exception of canopy cover, vegetational and edaphic characteristics are not affected by increased woody vegetation invasion within the system assessed. However, due to reduction in termite diversity and activity, increased woody vegetation invasion is a threat to termites and associated ecosystem services they provide. The investigation provided information at both community and ecosystem level for the savanna assessed on the need for insect conservation both within protected areas and surrounding landscapes. Since the study suggested that termite populations and associated activity could be reduced due bush encroachment, monitoring of the impacts of increasing woody plant invasions is essential for insect conservation and maintenance of savanna ecosystem function and heterogeneity.
Tetralogy of Fallot with vertebral defect and left aberrant subclavian artery: a rare occurrence
Authors: Hameed Marya , Qureshi Muhammad Fazal Hussain 
Published: February 2024

Abstract
Background
The most prevalent cyanotic congenital heart disease is Tetralogy of Fallot (TOF). It has a variety of presentations and is made up of four anatomic abnormalities. Documented literature shows an incidence of 13–20% of a right aortic arch with an anomalous left subclavian artery among individuals diagnosed with TOF. This is the first case that discusses the rare occurrence of overriding of the aortic arch along with the left aberrant subclavian artery and vertebral defect in a 3-week-old girl. Timely identification and management are pivotal in ensuring the best possible outcomes for these young patients.

Case presentation
A 3-week-old female child came with complaints of dyspnea, dysphagia, fatigue, and cyanosis on extreme crying, feeding, and moderate activity. Echocardiography revealed severe pulmonary stenosis with right ventricular dilatation and ventricular septal defect (VSD); a chest computed tomography was performed that revealed four characteristic features of TOF (pulmonary artery stenosis, VSD, right aortic root deviation, and concentric right ventricular hypertrophy) along with overriding of the aortic arch accompanied with the left aberrant subclavian artery (compressing the trachea and infundibulum) and vertebral defect (butterfly vertebra).

Conclusions
The case of this 3-week-old female infant emphasizes the importance of early and accurate diagnosis in congenital heart diseases, particularly when faced with complex presentations such as the TOF. It serves as a testament to the valuable role of advanced diagnostic imaging techniques in unraveling the complexity of congenital heart conditions.
Role of epinephrine in attenuating cytokine storm, decreasing ferritin, and inhibiting ferroptosis in SARS-CoV-2
Authors: EL-Molla Ashraf , Fetouh Fawzia Aboul , Bawazir Samir , Ali Yasser , Alwahby Yehya , Bahadeg Muhammad , Gotah Yousef , Badahdah Fatima Ahmed , Alsaeed Abdullatif H. , Basseet Abdullah 
Published: February 2024

Abstract
Background
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is the virus responsible for coronavirus disease 2019. It presents one of the most threatening pandemics in the history of humanity. The mortality and morbidity represent an unprecedented challenge to the modern medical era. SARS-CoV-2 results in acute respiratory distress syndrome, high concentrations of proinflammatory mediators, cytokine storm (CS) due to massive release of cytokines, hypercoagulation, and hemoglobin disintegration. Dysregulation of iron homeostasis, iron overload as indicated by high ferritin level, and ferroptosis are major factors in the pathogenesis of the disease. We report a case of SARS-CoV-2 in which the use of epinephrine (Epi) resulted in an unexpected attenuation of CS, decreasing ferritin level and inhibiting ferroptosis.

Case presentation
A 64-year-old male patient with a history of multiple medical comorbidities had been diagnosed with SARS-CoV-2. Further evaluation showed marked increase in inflammatory markers, severe hyperferritinemia, and lymphopenia in laboratory blood tests. The characteristic score of CS was strongly positive, and in addition to regular treatment, the patient received Epi due to development of acute generalized skin rash, severe itching, and edema of lips and tongue. Epi may have successfully terminated not only the acute cutaneous condition, but also have attenuated CS, decreased ferritin level, and other inflammatory markers in addition to complete patient’s recovery.

Conclusion
Epinephrine may attenuate CS and inhibit ferroptosis which is an iron-dependent, non-apoptotic mode of cell death. Epi interacts with ferric and/or ferrous iron and built a stable complex that impedes activation of beta-adrenergic receptors. Epi may cause marked decrease of ferritin and other inflammatory markers. Epi may be used to decrease iron overload which is associated with many medical diseases like type 2 diabetes mellitus and cardiometabolic diseases such as coronary heart disease and cerebrovascular disease. As a new clinical indication extensive studies are required for further assessment and possible therapeutic uses.
Designing and testing novel artificial shelter traps to mass-trap overwintering brown marmorated stink bugs: a proof-of-concept study in Northwestern China
Authors: Zhang Jin-Ping , Avila Gonzalo , Ma Gang , Mi Qian-Qian , Najar-Rodriguez Adriana , Chen Ju-Hong , Ma Chun-Sen , Zhang Feng 
Published: February 2024

Abstract

Background

Halyomorpha halys
Stål (Hemiptera: Pentatomidae), brown marmorated stink bug (BMSB), is a highly polyphagous invasive pest worldwide. It is also known to be a nuisance pest as it enters artificial structures, including human habitats, to overwinter and releases very unpleasant odours when disturbed. Overwintering populations can be trapped and killed collectively by targeting the aggregation behaviour of BMSB adults. However, efficient traps for catching overwinter population have not been yet developed and validated. A novel and effective trapping method would be to design shelter traps in the field that entice and mass-trap overwintering BMSB as they initiate to display their typical aggregation behavior and seek shelter in the traps.

Methods
In this study conducted in Northwestern China, we designed different BMSB overwintering shelter traps made of different materials (i.e., wood or corflute) and lock types (with/without lock, pyrometric or strip door lock) and tested their efficacy at two different sites and three different locations within sites. We also tested the efficacy of the traps with or without the presence of the BMSB aggregation pheromone.

Results
Although trapped BMSB numbers were generally low across all traps tested, the black corflute trap was found to attract the highest average number of BMSB males and females, followed by the wooden-made trap, the bee-hive box and finally the wooden-made locked trap, which attracted the lowest numbers of BMSB. The trapping efficacy was found to not be affected by experimental sites or locations nor by the presence of the BMSB aggregation pheromone lure.

Conclusions
Our results showed that traps made of black corflute with slit doors were generally preferred by overwintering BMSB. This preliminary proof-of-concept study provides valuable information for further improvement of novel overwintering traps that could be used to mass trap BMSB overwintering populations.
Egyptian framework for an age-friendly built environment
Authors: Abd Elaziz Nourhan Mohamed , Shawky Kariman Ahmed 
Published: February 2024

AbstractIn recent years, the Egyptian demographic has changed with an increasing number of older citizens who require special attention. The World Health Organization (WHO) identified 2020–2030 as the “Decade of Healthy Ageing” in response to the worldwide demographic changes. Many international organizations have identified the built environment features of age‐friendly communities, yet they have not been thoroughly analyzed in the Egyptian context. Today, urban designers and city planners have to establish age-friendly communities that can facilitate well-being in old age. The paper aims to provide “Egyptian framework for an age-friendly built environment E-FAB”, that can help architects, urban designers, and decision-makers evaluate Egyptian urban communities towards being age-friendly. The E-FAB is created and designed based on an analytical theoretical approach focused on active older people’s definitions, needs, their relation to the built and social environments, and previous practices of age-friendly cities and communities. In addition, a comparative analysis between previous studies in age-friendly communities. Then, the paper conducted semi-structured interviews targeting active older people, aiming to refine and rank the built environment features of the E-FAB by using SPSS. The findings revealed that the E-FAB is expected to be an initial simple evaluating framework that could contribute positively to improving Egyptian urban areas to be more friendly to older people and address their needs in the built environment.