bluuebunny/crossref_metadata_2025_split huggingface dataset:
Diagnosis of differentiated dysplasia as a variant of oral epithelial dysplasia
Authors: Becker Anne‐Sophie , Holm Maximiliane , Liese Jan , Engel Nadja , Zimpfer Annette Helene 
Published: January 2024

AbstractObjectivesThe World Health Organization's definition of oral epithelial dysplasia includes differentiated dysplasia, which is defined by purely architectural abnormalities of oral mucosa without cytological changes. We analysed differentiated dysplasia's frequency, progression risk and correlation with oral brush cytology.Materials and MethodsCytoarchitectural criteria and expression patterns of keratin 13/17 and ki67 were studied in oral biopsies clinically diagnosed with leukoplakia. Biopsies were assessed for dysplasia and its grade. Available brush cytology findings were obtained from clinical records.ResultsWe included 159 biopsies from 112 patients (33% differentiated dysplasia; 27% keratosis without dysplasia; oral epithelial dysplasia with atypia of mild, moderate and severe degree including invasive cancers in 9%, 8% and 7%, respectively). Keratin 13 loss and keratin 17 gain were higher in differentiated‐dysplasia cases (p < 0.0001), which had the highest hypergranulosis frequency. Keratin 17 expression was associated with higher malignant‐transformation rates (p = 0.0028). The transformation rate and time were comparable between dysplasia with atypia and differentiated‐dysplasia cases, which had higher progression rates and shorter time periods than keratosis cases without dysplasia (p = 0.08). Cytology prior to differentiated dysplasia all indicated normal oral mucosa.ConclusionsKeratin 17 but not oral brush cytology can help identify patients with differentiated dysplasia with higher risk for malignant transformation.
The association between chronotype profile and temporomandibular disorders among college students
Authors: Dan Ruichen , Li Jiaheng , Zhao Kangning , Yang Zijiang , Dong Yanhua , Fan Peidi , Cheng Qiaoyu , Wang Jun , Xiong Xin 
Published: January 2024

AbstractBackgroundTemporomandibular joint disorders (TMDs) are common in young adults, and the link between chronotype profile and TMDs is unclear.ObjectiveThis study examined TMD prevalence and chronotype distribution and explored the relationship between chronotype and TMDs in young adults.Materials and MethodsA total of 663 students from Sichuan University completed questionnaires. Chronotype profiles were assessed using the Morningness‐Eveningness Questionnaire, and TMDs were screened using the Fonseca Memory Index. To validate the findings, 68 TMD patients and 136 controls were enrolled.ResultsThe prevalence of TMDs was 69.7%, with significant differences among chronotype profiles. The intermediate profile was the most common chronotype. Eveningness profile was associated with higher TMDs prevalence and severity. Muscle pain and side movement difficulty scores were higher in eveningness and intermediate profiles. Female gender (OR 2.345; 95% CI 1.668–3.297) was a TMD risk factor, while morningness profile (OR 0.537; 95% CI 0.297–0.970) was protective. Validation with TMD patients and controls supported these findings, showing higher eveningness profile prevalence in the TMD groups.ConclusionsTMDs have a high prevalence in college students, chronotype profiles shown to be associated with TMDs. Morningness is the protection factor in TMDs and PT, eveningness is a risk factor for IT.
Measuring Union Formalization for a New Generation of Family Demography: A Case Study from Urban Kenya
Authors: Stoebenau Kirsten , Madhavan Sangeetha , Kim Seungwan , Wainaina Carol 
Published: January 2024

AbstractDespite repeated calls for improved measures of marriage as a process in sub‐Saharan Africa, large‐scale surveys continue to rely on static marital status. As a result, there is an incomplete understanding of the effects of marriage on outcomes of interest. We use qualitative and survey data from a longitudinal study of 1,203 young mothers residing in informal settlements of Nairobi, Kenya, to (1) describe the development of an innovative measure of union formalization (UF) defined as the steps through which a union attains social legitimacy; (2) compare UF with a conventional current marital status measure; (3) examine the distribution of UF steps across union history; and (4) examine the sequence and timing of pregnancy and childbearing within the UF process. We find UF steps indicative of both increasing individualization of marriage and the ongoing importance of kin involvement hold meaning. We demonstrate extensive heterogeneity in the sequence and extent of UF steps completed and interrogate the classification of premarital childbearing using sequence analysis. We argue that measuring UF is feasible and necessary for the next generation of family demography in Africa; UF measures facilitate understanding the linkages among family dynamics, health, and social stratification within the context of ongoing socioeconomic change.
A newly evolved rice‐specific gene JAUP1 regulates jasmonate biosynthesis and signalling to promote root development and multi‐stress tolerance
Authors: Muzaffar Adnan , Chen Yi‐Shih , Lee Hsiang‐Ting , Wu Cheng‐Chieh , Le Trang Thi , Liang Jin‐Zhang , Lu Chun‐Hsien , Balasubramaniam Hariharan , Lo Shuen‐Fang , Yu Lin‐Chih , Chan Chien‐Hao , Chen Ku‐Ting , Lee Miin‐Huey , Hsing Yue‐Ie , Ho Tuan‐Hua David , Yu Su‐May 
Published: January 2024

SummaryRoot architecture and function are critical for plants to secure water and nutrient supply from the soil, but environmental stresses alter root development. The phytohormone jasmonic acid (JA) regulates plant growth and responses to wounding and other stresses, but its role in root development for adaptation to environmental challenges had not been well investigated. We discovered a novel JA Upregulated Protein 1 gene (JAUP1) that has recently evolved in rice and is specific to modern rice accessions. JAUP1 regulates a self‐perpetuating feed‐forward loop to activate the expression of genes involved in JA biosynthesis and signalling that confers tolerance to abiotic stresses and regulates auxin‐dependent root development. Ectopic expression of JAUP1 alleviates abscisic acid‐ and salt‐mediated suppression of lateral root (LR) growth. JAUP1 is primarily expressed in the root cap and epidermal cells (EPCs) that protect the meristematic stem cells and emerging LRs. Wound‐activated JA/JAUP1 signalling promotes crosstalk between the root cap of LR and parental root EPCs, as well as induces cell wall remodelling in EPCs overlaying the emerging LR, thereby facilitating LR emergence even under ABA‐suppressive conditions. Elevated expression of JAUP1 in transgenic rice or natural rice accessions enhances abiotic stress tolerance and reduces grain yield loss under a limited water supply. We reveal a hitherto unappreciated role for wound‐induced JA in LR development under abiotic stress and suggest that JAUP1 can be used in biotechnology and as a molecular marker for breeding rice adapted to extreme environmental challenges and for the conservation of water resources.
Successful topical minoxidil treatment for hair density and length in trichorhinophalangeal syndrome type 1
Authors: Choi Mira , Han Allison , Eichenfield Lawrence F. 
Published: January 2024

AbstractA 9‐year‐old girl presented with slow hair growth and hair thinning since birth. Additionally, she had short stature and abnormally short fingers; genetic testing confirmed the diagnosis of trichorhinophalangeal syndrome (TRPS) type 1. After 4 months of topical minoxidil treatment, hair density and length significantly improved diffusely throughout the scalp without evidence of hypertrichosis. This case underscores the therapeutic potential of topical minoxidil for TRPS, paving the way for improved patient quality of life.
Digital surface model generation from high‐resolution satellite stereos based on hybrid feature fusion network
Authors: Zheng Zhi , Wan Yi , Zhang Yongjun , Hu Zhonghua , Wei Dong , Yao Yongxiang , Zhu Chenming , Yang Kun , Xiao Rang 
Published: January 2024

AbstractRecent studies have demonstrated that deep learning‐based stereo matching methods (DLSMs) can far exceed conventional ones on most benchmark datasets by both improving visual performance and decreasing the mismatching rate. However, applying DLSMs on high‐resolution satellite stereos with broad image coverage and wide terrain variety is still challenging. First, the broad coverage of satellite stereos brings a wide disparity range, while DLSMs are limited to a narrow disparity range in most cases, resulting in incorrect disparity estimation in areas with contradictory disparity ranges. Second, high‐resolution satellite stereos always comprise various terrain types, which is more complicated than carefully prepared datasets. Thus, the performance of DLSMs on satellite stereos is unstable, especially for intractable regions such as texture‐less and occluded regions. Third, generating DSMs requires occlusion‐aware disparity maps, while traditional occlusion detection methods are not always applicable for DLSMs with continuous disparity. To tackle these problems, this paper proposes a novel DLSM‐based DSM generation workflow. The workflow comprises three steps: pre‐processing, disparity estimation and post‐processing. The pre‐processing step introduces low‐resolution terrain to shift unmatched disparity ranges into a fixed scope and crops satellite stereos to regular patches. The disparity estimation step proposes a hybrid feature fusion network (HF2Net) to improve the matching performance. In detail, HF2Net designs a cross‐scale feature extractor (CSF) and a multi‐scale cost filter. The feature extractor differentiates structural‐context features in complex scenes and thus enhances HF2Net's robustness to satellite stereos, especially on intractable regions. The cost filter filters out most matching errors to ensure accurate disparity estimation. The post‐processing step generates initial DSM patches with estimated disparity maps and then refines them for the final large‐scale DSMs. Primary experiments on the public US3D dataset showed better accuracy than state‐of‐the‐art methods, indicating HF2Net's superiority. We then created a self‐made Gaofen‐7 dataset to train HF2Net and conducted DSM generation experiments on two Gaofen‐7 stereos to further demonstrate the effectiveness and practical capability of the proposed workflow.
Looking for trouble: (Infra‐)law enforcement, penal populism, and professional habitus against squatting in Italy
Authors: Pozzi Giacomo 
Published: January 2024

AbstractThis paper reflects ethnographically on law enforcement against squatting in Milan. To this end, it examines labor practices, moral economies, and everyday narratives of those who work with the institutional mandate of tackling squatting in public housing. I propose to grasp these processes considering two specific political and legal configurations that traverse the arena under investigation: the entrenched presence, in the Italian context, of what has been defined as penal populism; additionally, the increasingly pronounced prominence of an infra‐legal dimension of law. Squatting—and the way in which it is publicly managed and punished—represents a privileged lens for examining the specific forms of normative and political governance in contemporary cities.
Estimating the effect of diuretics and inhaled corticosteroids for evolving bronchopulmonary dysplasia in preterm infants
Authors: Slaughter Jonathan L. , Klebanoff Mark A. , Hade Erinn M. 
Published: January 2024

AbstractBackgroundOff‐label treatment of extremely preterm infants with diuretics and inhaled corticosteroids (ICS) for evolving bronchopulmonary dysplasia (BPD) is common. Their effectiveness in reducing mortality or BPD severity, and optimal treatment timing, are unclear.ObjectivesTo determine whether diuretic treatment or ICS administration for infants with early evolving (between 10–27 days postnatal) and progressively evolving (28th‐day–36th‐week postnatal) BPD are independently associated with reduced mortality and moderate or severe BPD at 36‐weeks postmenstrual age (PMA).MethodsWe examined neonates born before 28 weeks' gestation and admitted to neonatal intensive care units on postnatal Day 0 between 2006 and 2016 using data collected during routine care recorded within the Paediatric Health Information System (PHIS). An early evolving BPD cohort consisted of infants treated with oxygen, positive pressure or mechanical ventilation at 10 days postnatal. The progressively evolving BPD cohort consisted of infants treated with these modalities at 28 days. In new users, we evaluated the effect of diuretic and ICS treatment on mortality or BPD severity at 36 weeks PMA, adjusting for time‐dependent confounding by respiratory status using marginal structural models.ResultsEarly evolving BPD was present in 10,135 patients; progressively evolving BPD in 11,728. New diuretic exposure during early evolving BPD (adjusted risk ratio [aRR] 0.77, 95% confidence interval [CI] 0.65, 0.93) was associated with decreased mortality or moderate/severe BPD risk. New diuretics (aRR 0.86, 95% CI 0.75, 0.99) during progressively evolving BPD between 28‐days–36‐weeks PMA were less strongly associated with mortality or moderate/severe BPD reduction. There was no strong association for ICS in patients with early evolving (aRR: 1.40; 95% CI: 0.79, 2.51) or progressively evolving BPD (aRR 1.16, 95% CI 0.95, 1.49).ConclusionDiuretics, but not ICS, for evolving BPD were associated with mortality and BPD risk reduction.
Guided bone regeneration in implant dentistry: Basic principle, progress over 35 years, and recent research activities
Authors: Buser Daniel , Urban Istvan , Monje Alberto , Kunrath Marcel F. , Dahlin Christer 
Published: January 2024

AbstractBone augmentation procedures are frequent today in implant patients, since an implant should be circumferentially anchored in bone at completion of bone healing to have a good long‐term stability. The best documented surgical technique to achieve this goal is guided bone regeneration (GBR) utilizing barrier membranes in combination with bone fillers. This clinical review paper reflects 35 years of development and progress with GBR. In the 1990s, GBR was developed by defining the indications for GBR, examining various barrier membranes, bone grafts, and bone substitutes. Complications were identified and reduced by modifications of the surgical technique. Today, the selection criteria for various surgical approaches are much better understood, in particular, in post‐extraction implant placement. In the majority of patients, biodegradable collagen membranes are used, mainly for horizontal bone augmentation, whereas bioinert PTFE membranes are preferred for vertical ridge augmentation. The leading surgeons are using a composite graft with autogenous bone chips to accelerate bone formation, in combination with a low‐substitution bone filer to better maintain the augmented bone volume over time. In addition, major efforts have been made since the millenium change to reduce surgical trauma and patient morbidity as much as possible. At the end, some open questions related to GBR are discussed.
Fresh‐frozen allogeneic bone blocks grafts for alveolar ridge augmentation: Biological and clinical aspects
Authors: Stavropoulos Andreas , Marcantonio Camila Chierici , de Oliveira Vithor Xavier Resende , Marcantonio Élcio , de Oliveira Guilherme José Pimentel Lopes 
Published: January 2024

AbstractThe possibilities for oral bone regeneration procedures vary depending on the type of bone defect to be treated, which in turn dictate the type of graft to be used. Atrophic alveolar ridges are non‐contained defects and pose a challenging defect morphology for bone regeneration/augmentation. Successful results are regularly obtained with the use of particulate grafts in combination with barrier membranes. In cases of very narrow ridges with need of larger amount of bone augmentation, block grafts are often used. Fresh‐frozen allogeneic bone block grafts have been proposed as an alternative to autogenous (AT) bone blocks. Based on a systematic appraisal of pre‐clinical in vivo studies and clinical trials including a direct comparison of fresh‐frozen bone (FFB) blocks versus AT bone blocks it can be concluded that a FFB block graft: (a) cannot be considered as a reliable replacement of a AT bone block, and (b) should only be considered in cases where the amount of necessary augmentation—in a lateral direction—is relatively limited, so that the main portion of the body of the implant lies within the inner (i.e., the vital) aspect of the block.
Vegetation variety affected by local environments in a coral reef lagoon
Authors: Tozaki Kandai , Nishihara Gregory N. , Kawate Azusa , Konishi Teruko , Sato Yoichi , Ito Michihiro , Fujimura Hiroyuki , Tanaka Atsuko 
Published: January 2024

AbstractFrom shore to sea, coral reefs can generally be divided into a lagoon zone, a reef crest, and a fore reef. Environmental variables, such as nutrient fluxes, light availability, and water temperature, vary among the zones and influence the biodiversity of submerged macrophytes. Additionally, the biodiversity of vegetation within the lagoon appears to be affected by multiple and extremely localized conditions. We investigated the impact of small‐scale variations on vegetation diversity, and implemented an ecological survey within a well‐defined area inside of a lagoon at Bise Point, Okinawa, Japan. A total of 20 macroalgal species (four green algae, six brown algae, and ten red algae) and four seagrass species were identified from the surveyed quadrats over a period of 19 months, from October 2019 to March 2021. Patterns in species occurrence were spatially and temporally heterogeneous. Notably, water motion and sediment flux were highly variable among the monitoring sites. Redundancy analysis allowed us to evaluate the significance of environmental factors on the vegetation of each monitoring area. Six environmental factors were considered in this study, but their impacts on local vegetation were not equivalent. Redundancy analysis suggested that water depth, flow velocity, and the ratio of the small fraction of deposition particles were the three factors with the strongest influence on local vegetation. This study provides some crucial insights into the determinants of vegetation in a coral reef lagoon. Our findings suggest that the factors we examined exert more influence on the vegetation than seasonal effects.
Accounting for diversity in the treatment of suicide and self‐injury: A systematic review of the past 50 years of randomized controlled trials
Authors: Maria Guzmán Eleonora M. , LeDuc Michael K. , Cha Christine B. , Goger Pauline , Ng Mei Yi , Huang Xieyining , Ribeiro Jessica D. , Fox Kathryn R. 
Published: January 2024

AbstractPurposePatients receiving treatment for self‐injurious thoughts and behaviors (SITBs) have diverse backgrounds, yet it remains unclear exactly who is represented in the current SITB treatment literature.MethodsWe conducted a systematic review of the past 50 years of randomized controlled trials (RCTs) testing SITB treatments to evaluate sampling practices and reporting of sample characteristics, as well as inclusion of global populations across the included 525 papers. We also assessed changes over the past five decades in these three domains.ResultsSITB RCTs frequently reported age and sex (98.6%–95.1%), less frequently reported race (83.4%–38.6%), socioeconomic status (48.1%–46.1%) and ethnicity (41.9%–8.1%), and rarely reported LGBTQ+ status (3.7%–1.6%). U.S.‐based RCTs featured predominantly White, non‐Hispanic, and non‐LGBTQ+ samples. Most RCTs were conducted in high‐income North American or European countries. Sample reporting practices, sample representativeness, and inclusion of global populations modestly and inconsistently improved over time.ConclusionsThere has not been substantial improvement in reporting practices, sample representativeness, or inclusion of global populations in SITB RCTs over the past 50 years. Acknowledging who is being studied and representing diverse populations in SITB treatment research is key to connecting research advances with those who may need it most.
Adenovirus infection in adult patients undergoing allogeneic hematopoietic stem cell transplant: Incidence, clinical management, and outcome
Authors: Balletto Elisa , Ponzano Marta , Raiola Anna Maria , Gambella Massimiliano , Grazia Carmen Di , Dominietto Alida , Giannoni Livia , Ghiso Anna , Nicolini Laura Ambra , Sepulcri Chiara , Ullah Nadir , Bruzzone Bianca , Signori Alessio , Angelucci Emanuele , Bassetti Matteo , Mikulska Malgorzata 
Published: January 2024

AbstractBackgroundAdenovirus infection (ADVi) is an emergent complication in adult patients undergoing allogeneic hematopoietic stem cell transplantation (allo‐HSCT) and is associated with poor outcome. Available data on risk factors and optimal management of ADVi in adult allo‐HSCT recipients are limited, and recommendations on monitoring and pre‐emptive therapy are mainly based on pediatric data.MethodsIn this single‐center, retrospective study, we reported all cases of positive ADV‐DNA from adult patients undergoing allo‐HSCT in the period 2014–2019. The study aimed to describe the incidence of ADVi at day +180 post‐transplant. Secondly to describe timing, clinical presentation, risk factors, and outcome of ADVi and to analyze the application of a screening strategy in our cohort.ResultsIn 445 allo‐HSCT recipients, the day +180 incidence was: 9% (39/445) for ADVi, 5% (24/445) for ADV viremia (ADVv), and 3% (15/445) for localized ADVi. The median time to ADVi was 65 (IQR 19; 94) days after HSCT. ADVv‐related mortality was 13% (3/24), all cases occurring with blood max‐ADV‐DNA > 10^3 cp/mL. Independent risk factors for ADVi were diagnosis of lymphoproliferative disease (p = .011) and acute graft‐versus‐host‐disease (p = .021).ConclusionsIn our cohort, ADVi and ADVv were more frequent than previously reported. ADVv with max‐ADV‐DNA > 10^3 cp/mL was associated with ADV‐related mortality, thus careful monitoring and early initiation of treatment are advisable.
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