bluuebunny/crossref_metadata_2025_split huggingface dataset:
Lupus erythematosus‐like lesions in a carrier of X‐linked chronic granulomatous disease
Authors: Córdoba‐Guijarro S , Feal C , Daudén E , Fraga J , García‐Díez A 
Published: March 2003

AbstractChronic granulomatous disease (CGD) is an inherited immunodeficiency disease. Carrier status of CGD has been reported in association with lupus erythematosus‐type lesions. A 35‐year‐old woman, mother of a child with X‐linked CGD presented an 8‐year history of erythematous plaques with an arciform pattern on the upper trunk, back and arms. The nitroblue tetrazolium test revealed the carrier status of the patient. Haematological, biochemical and immunological tests (including ANA, DNA, SSA‐Ro, SSB‐La, RNP, SM and Jo1 antibodies) were normal or negative except for a polyclonal hypergammaglobulinaemia with high serum IgA. Histological examination showed a papillary and perifollicular lymphohistiocytic infiltrate. Direct immunofluorescence was negative. We report a female carrier of X‐linked CGD who developed clinical subacute lupus erythematosus‐like lesions. We review the literature and discuss the pathogenetic mechanisms involved in the condition.
Pemphigus vulgaris and disseminated nocardiosis
Authors: Martín Fj , Pérez‐Bernal Am , Camacho F 
Published: March 2003

AbstractInfectious diseases, in particular septicaemia from Staphylococcus aureus, Proteus vulgaris and Pseudomonas aeruginosa, are the most severe and frequent complications for the immunosuppressive therapy of pemphigus. Infection by Nocardia asteroides in subjects with pemphigus vulgaris is rare. We report the sixth case found of such an association; the subject died of disseminated nocardiosis while receiving steroids and immunosuppressive drugs, 4 years after being diagnosed with chronic pemphigus vulgaris.
Sporotrichosis masquerading as pyoderma gangrenosum: case report and review of 19 cases of sporotrichosis
Authors: Byrd DR , El‐Azhary RA , Gibson LE , Roberts GD 
Published: March 2003

ABSTRACTWe present the case of a 59‐year‐old woman who had large ulcerations on her right leg that were diagnosed initially as pyoderma gangrenosum and treated with three immunosuppressive agents (cyclosporin, prednisone and azathioprine) for 6 months. Results of a biopsy at 6 months showed numerous cigar‐shaped bodies consistent with Sporothrix schenckii; identification was confirmed by tissue culture. A retrospective review was performed for all cases diagnosed as sporotrichosis from tissue culture or biopsy specimens at the Mayo Clinic. Nineteen cases were identified. The present case was the only one in which fungal organisms were visible on histological examination. The present case emphasizes the importance of making a definitive histological diagnosis in unusual ulcer cases or in suspected cases of pyoderma gangrenosum before the initiation of immunosuppressive therapy. The large number of cigar‐shaped bodies in the tissue is a rare finding in sporothrix infection and has been reported in only two cases previously.
Increased incidence of pemphigus vulgaris in southern Europeans living in Germany compared with native Germans
Authors: Hahn‐Ristic K , Rzany B , Amagai M , Bröcker E‐B , Zillikens D 
Published: March 2003

AbstractBackground The two major subtypes of pemphigus include: pemphigus vulgaris (PV) and pemphigus foliaceus. Only limited data are available on the epidemiology of these diseases.Objective The aim of the present study was to estimate the gender‐ and age‐specific incidences of PV in two well‐defined regions of Germany and to compare the incidences among native Germans with those in citizens from other countries living in Germany.Methods We performed a retrospective review of records from all patients that were diagnosed with PV at the Departments of Dermatology in Würzburg and Mannheim between 1989 and 1997.Results During the observation period, 14 patients were diagnosed with PV coming from an area with 1.46 million residents. With regard to the patients’ age, the highest incidence for women was found in the 51–65‐year‐old‐age group with 2.34 [95% confidence interval (CI): 0.36; 7.76] new cases per 1 million inhabitants per year. The highest incidence for men was observed in the over 65‐year‐old age group with 3.72 (95% CI: 0.95; 9.8) cases/million per year. In the 51–65‐year‐old age group, we found a 25‐fold higher incidence of PV in foreigners living in Germany compared with native Germans. The age‐adjusted incidence of PV was ninefold higher in foreigners compared with native Germans. Interestingly, all non‐German patients came from two southern European countries (Turkey and Italy).Conclusions The age‐adjusted incidence of PV differs between native Germans and foreigners living in Germany. Further studies are necessary to address the risk factors (genetic and/or environmental) that contribute to this difference.
Primary cutaneous plasmacytosis in a child. Is this a new entity?
Authors: Aricò M , Bongiorno MR 
Published: March 2003

AbstractPlasma cell proliferations represent a heterogeneous spectrum of disorders. A 7‐year‐old Caucasian female had suffered an asymptomatic eruption on the trunk for 4 years. Physical examination revealed a plaque with scattered red–brown papules and nodules. Chemical analysis revealed normal proteinaemia. Histological examination of biopsy specimens showed dense perivascular and periadnexal infiltrate, consisting largely of plasma cells, in the superficial and deep dermis. Immunohistochemical study showed that many cells of the infiltrate were CD20 positive. The plasma cells expressed κ and λ light chains. The girl’s status (age; absence of hypergammaglobulinaemia, lymphadenopathy and hepatosplenomegaly; presence of an infiltrate of mature polyclonal plasma cells restricted only to the skin) differed from those generally seen in diseases with plasma cell proliferation reported in the literature. This case seems unlike any other described up to the present time.
The effects of 17 August Marmara earthquake on patient admittances to our dermatology department
Authors: Bayramgürler D , Bilen N , Namlı S , Altinaş L , Apaydın R 
Published: March 2003

AbstractOn 17 August 1999 a devastating earthquake with a magnitude of 7.4 on the Richter scale occurred in Marmara region of Turkey and the epicentre of the earthquake was our city. In this study we aimed to determine the influence of a major earthquake on patient admittance's to the outpatient clinic of our dematology department. All the registrations of the outpatient clinic of our dermatology department in a period of 6 months after the earthquake and the same period last year were revised retrospectively and categorized into 15 subgroups. The first 3 months registrations (earthquake group 1) and the second 3 months registrations (earthquake group 2) after the earthquake were compared with those of the same periods in last year, respectively (control group 1 and control group 2). Also the earthquake group 1 was compared with the earthquake group 2. When the results were evaluated, it was seen that the incidence of infections‐infestations was significantly higher in the earthquake group 1 when compared with the control group 1. When the earthquake group 2 and the control group 2 were compared with each other regarding the incidences of the skin diseases, no statistically significant difference was found. The incidences of erythematous‐squamous skin diseases, pruritus and neurocutaneous dermatoses and eczemas were significantly higher in the earthquake group 2 when compared with the earthquake group 1. On the other hand, the incidences of infections‐infestations and dermatoses due to physical factors were significantly lower in the earthquake group 2 when compared with the earthquake group 1. We think that the alteration in the admittance's to outpatient clinic of our dermatology department in the first 3 months after the earthquake is due to the damaged infrastructures and unhygienic life conditions and in the second 3 months is due to psycho‐emotional factors related to earthquake.
Pityriasis alba: a study of pathogenic factors
Authors: Blessmann Weber M , Sponchiado de Ávila LG , Albaneze R , Magalhães de Oliveira OL , Sudhaus BD , Ferreira Cestari T 
Published: March 2003

AbstractBackground The aetiology of pityriasis alba (PA), a common dermatosis in childhood, is still controversial. The objective of this study was to assess the possible aetiopathogenic factors of this disease in infants.Methods Forty‐four patients with PA and 31 healthy children were examined and compared. Personal hygiene habits, sun exposure, presence of Staphylococcus aureus in nasal fossae and presence of major or minor signs of atopy were assessed during anamnesis and physical examination. Susceptibility to ultraviolet (UV) B radiation was measured by the onset of a contact hypersensitivity reaction to diphenylcyclopropenone in individuals sensitized in previously irradiated areas.Results The prevalence of PA was higher in individuals with darker skin, in high phototype categories, as well as in males. The number of daily baths and sun exposure between 10.00 h and 15.00 h were significantly higher in the PA group when compared with controls (P = 0.03 and P = 0.0015, respectively). The presence of atopy signs was more common in pityriasis patients (P = 0.002). Susceptibility to UVB radiation was 29.6% in the PA group vs. 29.0% in the control group; nevertheless, important differences were found after stratification in order to control possible confounding factors. The presence of S. aureus in the nostrils was equal in both groups.Conclusions Our results confirm that PA, in our population, is more prevalent in males and in individuals in higher phototype categories. In those with inadequate personal hygiene and sun exposure habits the disease is more accentuated, demonstrating that the xerosis presenting in individuals with atopic diathesis is an important element in the development of the disease. S. aureus is not an important aetiopathogenic factor in PA. Susceptibility to UVB becomes important when related to the patient's phototype.
Manifestation of cellulitis after saphenous venectomy for coronary bypass surgery
Authors: Karakaş M , Baba M , Aksungur VL , Memişoǧlu HR , Aksungur EH , Denli YG , Karakaş P 
Published: March 2003

AbstractA few cases of onset of cellulitis after saphenous venectomy for coronary by‐pass surgery were first reported by Baddour and Bisno in 1982. We reviewed the clinical characteristics of 31 subjects followed up in our department following onset of manifestations of cellulitis after saphenous venectomy for coronary by‐pass surgery. In all the subjects the cellulitis originated at the scar of the saphenous venectomy, and most presented ill‐defined, mildly erythematous, slightly oedematous lesions. Mycologically confirmed tinea pedis was found in 25 subjects. All the patients responded well to penicillins or cephalosporins.In this report we comment on the pathogenesis of this complication of saphenous venectomy based on the clinical features of the cases reviewed. We suggest that saphenous venectomy may destroy the lymphatics in the lower leg, that are located adjacent to the great saphenous vein, and thus microorganisms penetrating into the skin may easily cause cellulitis in areas with impaired lymphatic drainage.
Sodium‐Valproate‐Induced Pancreatitis in a Man with Profound Intellectual Disability: the Significance of Diagnostic Difficulties
Authors: Hinder Steve , Perry David 
Published: March 2003

AbstractPancreatitis is a common but under‐reported complication of treatment with sodium valproate, a drug frequently prescribed for people with intellectual disabilities. The present authors report a case of valproate‐induced pancreatitis in a man with profound intellectual disability and review the relevant literature. The wider implications of problems experienced with diagnosis are discussed, emphasizing difficulties in recognizing pain and physical illness in this client group.
Differentiated Coping Strategies in Families with Children or Adults with Intellectual Disabilities: the Relevance of Gender, Family Composition and the Life Span
Authors: Grant G. , Whittell B. 
Published: March 2003

AbstractThe present paper considers the coping strategies of families with children and adults with intellectual disabilities. It is argued that the literature on coping and resilience in families has often been overlooked in favour of deficit models of family functioning. The present study was designed to provide a further test of the transactional model of coping, but more especially, to explore which problem‐solving, cognitive and stress reduction coping strategies family members found useful. Based on the use of a coping inventory Carers Assessment of Managing Index (CAMI), coping is shown to be differentiated according to gender, life stage and family structure. Implications for continuing research into family care are considered and some questions are raised about family support.
Sampling success and risk by transabdominal chorionic villus sampling, transcervical chorionic villus sampling and amniocentesis: a randomized study
Authors: Smidt‐Jensen S. , Permin M. , Philip J. 
Published: March 2003

AbstractA total of 3347 women were randomized to either transabdominal chorionic villus sampling, transcervical chorionic villus sampling or amniocentesis. Unless induced or spontaneous abortion had occurred, they had all completed up to 28 weeks of pregnancy at the time of analysis. No significant difference was seen between total fetal loss in the transabdominal chorionic villus sampling group and the amniocentesis group (6.2% and 6.6%, respectively, SE difference 0.92%, p = 0.01). The total fetal loss in the transcervical group was 10.1%. When the number of failed procedures and those cases which were evaluated as infeasible for the assigned method, are compared, the overall sampling efficacy is less good transcervically than transabdominally. After pooling our data with data from the Canadian randomized study and the American non‐randomized study, the difference in risk between transcervical chorionic villus sampling and amniocentesis was 2.1%, SE difference = 0.64%, p = 0.8. Copyright © 1991 International Society of Ultrasound in Obstetrics and Gynecology
Transvaginal ultrasonic assessment of the early fetal brain
Authors: Achiron R. , Achiron A. 
Published: March 2003

AbstractThe introduction of high resolution transvaginal transducers has expanded our knowledge of the first and early second‐trimester fetus. This article describes transvaginal assessment of normal brain development. The feasibility of early detection of various fetal central nervous anomalies, such as anencephalus, exencephalus, hydrocephalus, Dandy Walker syndrome and myelomeningocele is described. Copyright © 1991 International Society of Ultrasound in Obstetrics and Gynecology
Validity of pulsatility and resistance indices in classification of adnexal tumors with transvaginal color Doppler ultrasound
Authors: Tekay A. , Jouppila P. 
Published: March 2003

AbstractTransvaginal pulsed color Doppler ultrasound was used to examine 72 patients with a pelvic mass preoperatively. Tumor morphology was assessed, prominent areas of vascularization within the tumor were observed and the pulsatility index and the resistance index of tumor and uterine arteries were measured. Flow velocity waveforms with low pulsatility are considered to reflect neovascularization. The ultrasound diagnoses were compared with histopathological or cytological diagnoses. There were 61 benign, eight malignant and three borderline cases. In 75% of the malignant and 23% of the benign tumors, an intratumoral flow with a low pulsatility was detectable. The mean pulsatility index of tumor blood vessels was 1.2 in benign, 0.7 in malignant and 0.6 in borderline neoplasms. The corresponding mean resistance index values were 0.6, 0.5 and 0.5. The differences were not significant and the overlap between the malignant and benign lesions was large. The pulsatility index and resistance index of uterine arteries were significantly decreased in malignant tumors. The results show that, using a cut‐off resistance index value of 0.6, the sensitivity and specificity of color Doppler in the detection of malignant and potentially malignant tumors were 82% and 72%, respectively. However, a practical cut‐off level for either pulsatility or resistance indices, that could assist in differentiating between malignant or benign lesions, does not seem to exist. Copyright © 1992 International Society of Ultrasound in Obstetrics and Gynecology
The interpretation of uterine artery pulsatility index in normal and hypertensive pregnancy
Authors: Grunewald C. , Kublickas M. , Nisell H. , Nylund L. , Westgren M. 
Published: March 2003

AbstractThe Doppler flow velocity pulsatility index (PI) of the uteroplacental vascular bed is of debatable value for the interpretation of hemodynamic changes, when these are due both to pathological alterations in the vasculature, as in mild pre‐eclampsia, and to physiological adjustments to vasoactive substances. The aim of this study was to apply a mathematical model, which includes maternal pulse pressure and mean arterial pressure, to the PI and to investigate whether this formula would add information with respect to discrimination between normal women and those with mild or severe pre‐eclampsia. The subjects were patients with mild (n = 41) and severe (n = 34) pre‐eclampsia and, as a control group, healthy pregnant women (n = 46). The uterine artery PI was studied by spectral Doppler analyses and compared to a Pz
value, theoretically representing a ‘back pressure’ in the uteroplacental circulation. Additionally, Pz
values were computed from earlier data concerning the dynamic circulatory effects of dihydralazine and acute volume expansion. The basal PI was significantly higher in the severely pre‐eclamptic patients but not in the mildly pre‐eclamptic patients compared to the controls. However, the Pz
was significantly higher in patients with both mild (p < 0.001) and severe pre‐eclampsia (p < 0.0001) compared to the normal group. In the severely pre‐eclamptic patients receiving dihydralazine, the Pz
tended to decrease (p = 0.07), in contrast to the volume‐expansion group where Pz
was unaffected by the procedure. In conclusion, it seems that including measurement of the mean arterial pressure and pulse pressure with the PI adds valuable information about the circulatory status in this particular vasculature, regarding both ‘basal’ values and hemodynamic changes. Copyright © 1994 International Society of Ultrasound in Obstetrics and Gynecology
Chromosomal defects and outcome in 1015 fetuses with increased nuchal translucency
Authors: Pandya P. P. , Kondylios A. , Hilbert L. , Snijders R. J. M. , Nicolaides K. H. 
Published: March 2003

AbstractIn 1015 fetuses undergoing first‐trimester karyotyping because of increased nuchal translucency thickness, the incidence of chromosomal abnormalities increased with both maternal age and nuchal translucency thickness. The observed numbers of trisomies 21, 18 and 13 in fetuses with nuchal translucency thicknesses of 3 mm, 4 mm, 5 mm and ≥ 6 mm were approximately 3 times, 18 times, 28 times and 36 times higher than the respective numbers expected on the basis of maternal age. The incidences of Turner syndrome and triploidy were 9‐fold and 8‐fold higher but the incidence of other sex chromosome aneuploidies was similar to that of an unselected population of women undergoing first‐trimester fetal karyotyping for maternal age. In the chromosomally normal group, the incidence of structural defects, mainly cardiac, diaphragmatic, renal and abdominal wall, was approximately 4%, which is higher than would be expected in an unselected population. The rates of fetal loss in the groups with nuchal translucency thickness of 3 mm and 4 mm were 2% and 4%, respectively, which is similar to the 2.3% rate of fetal loss observed in a group of fetuses with normal nuchal translucency thickness undergoing chorion villus sampling. For fetal nuchal translucency thickness of ≥ 5 mm, the rate of fetal loss was 13%. Copyright © 1995 International Society of Ultrasound in Obstetrics and Gynecology
Early development of the hindbrain: a longitudinal ultrasound study from 7 to 12 weeks of gestation
Authors: Blaas H.‐G. , Eik‐Nes S. H. , Kiserud T. , Hellevik L. R. 
Published: March 2003

AbstractTwenty‐nine healthy pregnant women were examined by transvaginal ultrasound to evaluate embryonic development in vivo between 7 and 12 weeks of gestation. The rhombencephalon with its fourth ventricle, the cerebellum and the choroid plexuses of the fourth ventricle were identified and measured. The cavity of the rhombencephalon, the future fourth ventricle, was always visible from 7 weeks, initially lying superiorly in the head of the embryo. The cerebellum and the choroid plexuses of the fourth ventricle became distinguishable during week 8. The volume of the rhombencephalic cavity was estimated. The shape and size of these rhombencephalic structures, their position in relation to each other and their relation to other brain structures changed specifically during the embryonic and early fetal period. This sonoembryological development corresponded to the descriptions in classical embryological literature. Copyright © 1995 International Society of Ultrasound in Obstetrics and Gynecology
Role of transvaginal ultrasound color flow imaging and Doppler waveform analysis in differentiating between benign and malignant ovarian tumors
Authors: Anandakumar C. , Chew S. , Wang Y. C. , Chia D. , Ratnam S. S. 
Published: March 2003

AbstractThis study was undertaken to assess the usefulness of ultrasound color flow imaging and Doppler waveform analysis in differentiating between benign and malignant ovarian tumors.From 1991 to 1993, 146 patients with 1.56 ovarian tumors underwent transvaginal scanning with color flow imaging and Doppler waveform analysis prior to surgery. All the ovarian tumors were removed surgically and confirmed histologically.The sensitivity and specificity of color flow imaging in identifying malignant ovarian tumors was 76.5% and 68%, respectively. Positive and negative predictive values were 40% and 91.2%, respectively. The addition of Doppler waveform analysis failed to produce statistically better results. Seven of the eight cases of ovarian cancer were missed by color Doppler. There were no solid areas present and malignancy was not suspected. Both modalities also failed to identify any case of ovarian cancer presenting as a simple cyst. Copyright © 1996 International Society of Ultrasound in Obstetrics and Gynecology
Antenatal diagnosis of a late abdominal pregnancy using ultrasound and magnetic resonance imaging: a case report of successful outcome
Authors: Hall J. M. , Manning N. , Moore N. R. , Tingey W. R. , Chamberlain P. 
Published: March 2003

AbstractA case of an advanced abdominal pregnancy diagnosed by ultrasound and magnetic resonance imaging (MRI) at 21 weeks' gestation is presented. The complementary roles of ultrasound and MRI in achieving accurate diagnosis and the role of ultrasound in ongoing pregnancy assessment are emphasized. Copyright © 1996 International Society of Ultrasound in Obstetrics and Gynecology
Color Doppler sonography of tubal torsion
Authors: Baumgartel P. B. , Fleischer A. C. , Cullinan J. A. , Bluth R. F. 
Published: March 2003

AbstractThese case reports illustrate the clinical and color Doppler sonographic findings in two cases of isolated tubal torsion. This condition may be associated with prior tubal ligation. The presence of high impedance or absent flow in a tubular structure in a patient with a history of tubal ligation should make one suspect this condition. Copyright © 1996 International Society of Ultrasound in Obstetrics and Gynecology