bluuebunny/crossref_metadata_2025_split huggingface dataset:
Actualización del diagnóstico y manejo del neumotórax catamenial asociado al síndrome de endometriosis torácica
Authors: Miranda Coello Michael Gustavo , Cárdenas Cevallos Indry Egube , Bermeo Villacres Alfonso Darío , Cárdenas Cevallos Micaela Lissette , Miranda Coello Katherine Cristina 
Published: November 2023

Introducción: El neumotórax catamenial (NC), es la presentación clínica más frecuente del síndrome de endometriosis torácica (SET), la cual se caracteriza por un neumotórax espontáneo primario recurrente en relación con la menstruación y la presencia de tejido endometrial en los pulmones y la pleura. Objetivo: Describir el diagnóstico y manejo del neumotórax catamenial asociado al síndrome de endometriosis torácica. Métodos: Se realizó una búsqueda bibliográfica utilizando las bases de datos PubMed, Nature, Science Direct, Scielo, Cochrane, The Lancet, The New England Journal of Medicine sobre el “síndrome de endometriosis torácica”, “neumotórax catamenial” y “neumotórax espontáneo”. Resultados: Se encontraron 60 fuentes bibliográficas relacionados con el NC publicados en los últimos 5 años, de los cuales se seleccionaron 31 considerando los criterios de inclusión y exclusión. Discusión: El NC afecta con mayor frecuencia a mujeres con una edad promedio de 34 a 37 años, cuya incidencia puede llegar al 41% de todos los neumotórax. La explicación más aceptada es la teoría de la menstruación retrógrada, afectando con mayor frecuencia al hemitórax derecho con un 73%. Los síntomas más predominantes son la disnea, dolor pleurítico, tos y a menudo se relaciona con la dismenorrea e infertilidad. El diagnóstico se realiza mediante la historia clínica, pruebas de imagen y citológicas. Conclusiones: Actualmente la cirugía toracoscópica asistida por video (VATS) es la mejor opción para el diagnóstico y tratamiento, que junto con la terapia hormonal evita su recurrencia.
Discovery of the novel auxiliary factor for β-lactam resistance BlrA in community-acquired methicillin-resistant Staphylococcus aureus
Authors: Astudillo Skliarova Igor Eduardo 
Published: November 2023

Methicillin-resistant Staphylococcus aureus (MRSA) is one of the most important human pathogens that cause a variety of infections in community and hospital settings. This organism displays high levels of resistance to β-lactam antibiotics and this principally occurs due to the production of β-lactamase and the penicillin binding protein PBP2a encoded by mecA gene. Furthermore, additional mechanisms, such as auxiliary factors, significantly contribute to β-lactam resistance. However, the function of most of these factors is still unknown.
Recently, in our laboratory, the novel auxiliary factor gene blrA was initially identified by transposon mutagenesis in the community-acquired MRSA strain JE2. Next, the transposon mutation was transduced to the community-acquired MRSA strain MW2, resulting in the formation of a transposon mutant for blrA (blrA::ermB), denoted as MW2A. Initially, our results suggested that MW2A is more susceptible to oxacillin than the MW2 wild-type. Then, we performed the Minimum Inhibitory Concentration (MIC) method for the β-lactam antibiotics: oxacillin, cefoxitin, cephradine, ceftazidime, cefaclor and imipenem. MW2A exhibited a two-fold reduction for all tested β-lactam antibiotics compared to the MRSA wild-type strain MW2. Additionally, no phenotypical changes were observed after performing PBP2a latex agglutination test and phage spot assay. Finally, using DeepTMHMM we show that BlrA is likely to act intracellularly, which is typical of auxiliary factors.
In this study, we show that BlrA is clearly involved in β-lactam resistance, but does not affect the expression of the gene mecA or the structure of the wall teichoic acids. Furthermore, we propose that that BlrA acts as an auxiliary factor and is activated in response to antimicrobial stress.
Recomendaciones sobre el consumo de los componentes bioactivos relacionados con las variantes genéticas de la obesidad y sus comorbilidades
Authors: Calderón Abad Paula Catalina 
Published: November 2023

Introducción: Los SNP en genes implicados en la absorción, disponibilidad, metabolismo y excreción de componentes bioactivos contribuyen a la variabilidad interindividual de sus mecanismos fisiológicos que pueden intervenir en la salud y enfermedad del paciente. Objetivo: Elaborar una matriz de recomendaciones sobre el consumo de bioactivos dietéticos de potencial interés en el control de la obesidad y sus comorbilidades. Método: El artículo se basó en una búsqueda bibliográfica empleando dos ecuaciones de búsqueda que permitieron identificar criterios relevantes sobre la influencia de los polimorfismos en las recomendaciones dietéticas de componentes bioactivos. Resultados: La búsqueda bibliográfica permitió encontrar 25 interacciones de 8 tipos de bioactivos/extractos con 20 polimorfismos de nucleótido único (SNPs) en 14 genes. Estas interacciones se registraron en una matriz para facilitar la comprensión sobre la influencia de las variantes genéticas en la respuesta a bioactivos en la obesidad. Discusión: Entre las interacciones identificadas, se destaca el papel protector frente a enfermedades cardiovasculares de la quercetina en el genotipo de la apolipoproteína E, la relación de la ingesta de esteroles vegetales, los haplotipos del gen NPC1L1 y la disminución de colesterol LDL así como la respuesta al extracto Bofutsushoan en la disminución de la grasa abdominal. Conclusiones: Aunque los estudios sobre las diferentes interacciones son limitados, la integración del estudio de la expresión génica como parte de la evaluación del estado de nutrición de los pacientes podría ser de utilidad para la personalización de las recomendaciones que se brindan durante la consulta por parte de los profesionales de salud y nutrición.
Programa de formación vivencial para prevención de violencia de género, dirigido a líderes y lideresas indígenas de la provincia de Chimborazo.
Authors: Moína Samaniego Aída María , Berrones Berrones Olwaldo Mateo , Ochoa Saeteros Diana Ximena , Ochoa Saeteros Ana Cristina 
Published: November 2023

El programa educativo constituye una herramienta efectiva para la prevención de la violencia de género, proporciona información detallada sobre las causas, consecuencias, así como el desarrollo de estrategias que contribuyan a la convivencia armónica, comunicación asertiva, habilidades de negociación y resolución de conflictos, todo esto vinculado a la prevención de la violencia. El objetivo de la intervención fue establecer una metodología de formación vivencial para líderes y lideresas indígenas en materia de prevención de violencia de género. Entre los métodos y técnicas, el programa se desarrolló mediante una Investigación de enfoque cualitativo de tipo Investigación Acción Participativa (IAP), fue dirigido a 35 mujeres líderes y 21 hombres líderes de Chimborazo, se ejecutó en un proceso de formación vivencial con el apoyo de la pedagogía constructivista. La metodología empleada permitió el desarrollo de actividades prácticas, lúdicas y vivenciales que generaron procesos de análisis y reflexiones en torno a la autoestima, proyecto de vida, manejo de emociones y las relaciones interpersonales. Los resultados mostraron una mejora en las habilidades sociales, confirmando que los talleres vivenciales desarrollados promueven una mejor convivencia y adecuadas relaciones interpersonales a nivel familiar y comunitario. Como conclusiones, se elaboraron de forma participativa dos guías metodológicas de facilitación diseñadas de acuerdo con las realidades de la población indígena de Chimborazo. Los talleres implementados generaron aprendizajes significativos propios y entre sus familiares, amigos y vecinos, lo cual contribuye a procesos de cambio social a nivel comunitario.
The quality switchgrass depends on the year of vegetation of the culture
Authors: Dryha V. V. , Doronin V. A. , Kravchenko Yu. A. , Honcharuk H. S. , Doronin V. V. 
Published: November 2023

The purpose of the research was to find out the peculiarities of the formation of seed quality, specifically germination energy, germination and 100 kernel weight of switchgrass, depending on the period of its vegetation.
Methods. Laboratory, measuring and weighing, mathematical and statistical.
Results. It was found that the quality of the seeds did not depend on the year of sowing. On average over four years, germination energy and germination of seeds collected from switchgrass plants sown in 2009 (the 10th year of vegetation) were 64% and 65%, respectively. The same indicators of the plants sown in 2014 (8th year of vegetation) were significantly lower and accounted for 57 and 60%, respectively. In 2016, (3rd year of vegetation) they were significantly higher — 74 and 75%. Study of the factors that affect seed qualityrevealed, that the greatest influence of the ‘vegetation period’ factor was 52.2%, and the influence of the ‘vegetation conditions’ factor was much smaller and amounted to 16.6%. Studies of seed germination by years of vegetation of switchgrass of all sowing years did not reveal a natural decrease of this indicator depending on the year of sowing.
Conclusions. Germination energy and germination of switchgrass depended not so much on the year of sowing but on the period of vegetation; no regular decrease or increase of these indicators was found. Significantly higher indicators of germination energy and germination were obtained in all years of vegetation from plants sown in 2011 and 2012.
Role of Risk Assessment and Mitigation in Strategic Planning in Nigeria
Authors: Olumide Samuel 
Published: November 2023

Purpose: The aim of the study was to investigate the role of risk assessment and mitigation in strategic planning in Nigeria.
Methodology: The study adopted a desktop methodology. Desk research refers to secondary data or that which can be collected without fieldwork. Desk research is basically involved in collecting data from existing resources hence it is often considered a low cost technique as compared to field research, as the main cost is involved in executive’s time, telephone charges and directories. Thus, the study relied on already published studies, reports and statistics. This secondary data was easily accessed through the online journals and library
Findings: The study on risk assessment and mitigation in Nigerian strategic planning reveals a recognition-action gap in organizations. Despite understanding the importance of risk management, many lack a structured approach to address threats. Common risks include political instability, security concerns, corruption, regulatory changes, and economic volatility. To improve decision-making and stakeholder value, the study recommends a more integrated and systematic approach to risk management within Nigerian organizations.
Unique Contribution to Theory, Practice and Policy: Game Theory, Resource-Based View (RBV) Theory & Institutional Theory may be used to anchor future studies on the role of risk assessment and mitigation in strategic planning in Nigeria. Nigerian strategic planning should create context-specific risk maps that outline the geographical distribution of risks and vulnerabilities within the country. Nigerian policies should prioritize investments in building resilience to identified risks.
Propuesta teórico-metodológica para análisis de desarrollo sustentable desde un enfoque de sistemas socio ecológicos
Authors: LÓPEZ SANTOS JONATHAN 
Published: November 2023

En México la promoción del desarrollo sustentable a nivel local es una responsabilidad primordial de los gobiernos municipales, no obstante, habitualmente los planes de desarrollo municipal están basados en diagnósticos descriptivos, que, si bien permiten conocer las características del territorio en un momento determinado, no sirven para entender los procesos sociales implicados en la emergencia del desarrollo sustentable. Además, son diagnósticos que, por un lado, no consideran los procesos de interacción entre subsistemas territoriales, y por el otro, no hacen un análisis de los elementos que determinan la sustentabilidad de los procesos de desarrollo.
En la actualidad existen varias metodologías para el análisis del desarrollo sustentable, no obstante, no han sido diseñadas para análisis de tipo territorial ni mucho menos sistémico. Entre las más utilizadas se pueden mencionar, el barómetro de sustentabilidad, los indicadores asociados a los Objetivos del Desarrollo Sustentable, y la metodología Presión-Estado- Respuesta (PER). Resulta indispensable contar con un marco de referencia que permita la comprensión de las dinámicas subyacentes al desarrollo sustentable, visualizando los mecanismos de interacción y auto organización entre subsistemas territoriales, así como, la capacidad de resiliencia territorial.
En tal sentido, el presente ensayo pretende brindar un marco teórico-metodológico para la evacuación del desarrollo sustentable que permita brinda información a escala local-territorial para que los tomadores de decisiones analicen, reorienten y evalúen las acciones necesarias para transitar hacia el desarrollo sustentable. Se propone un modelo de evaluación del desarrollo sustentable de tres etapas que busca caracterizar los subsistemas territoriales, evaluar los procesos de sinapsis y sinergia entre actores territoriales y conocer las condiciones para promover la resiliencia del sistema territorial.
Avaliação de desempenho para apoio à motivação e ao reconhecimento à pesquisa: uma proposta construtivista no ambiente universitário
Authors: Martins Vinicius Abilio , Ensslin Sandra Rolim , Damke Eloi Junior 
Published: November 2023

Universidades que não possuem tradição em pesquisa podem experimentar desmotivação por parte de seus atores em relação à prática dessa atividade. A avaliação de desempenho (AD) pode servir como um mecanismo de reconhecimento e motivação para incentivá-los à realização da pesquisa. Este estudo objetivou estruturar qualitativamente um modelo de AD para uma universidade sem tradição em pesquisa. Utilizou-se como instrumento de intervenção o Multi-criteria decision aid constructivist methodology (MCDA-C), norteado por uma abordagem construtivista. Dessa forma, pode-se construir o conhecimento necessário para a identificação dos 37 indicadores, sendo 08 para avaliação de cada curso, 15 para avaliação de cada docente e 14 para avaliação de cada discente, que representam aspectos necessários e suficientes pelo coordenador-chefe da área de Pesquisa de uma universidade pública, localizada na região Sul do Brasil. Pelo fato de a Avaliação de Desempenho ser um fenômeno social, o conhecimento e as informações geradas pelo modelo estruturado serviu como um canal de comunicação e de possível modificação do comportamento dos docentes/discentes à partir do estímulo à pesquisa, com vistas à um desempenho organizacional mais competitivo.
Oberpfälzerin wird neue Mehlkönigin
Authors: Schultz Olaf 
Published: November 2023

Frankfurt a.M. Unser Grundnahrungsmittel Nummer eins, das Mehl, hat eine neue Botschafterin: Anna-Theresa Ramsauer, Müllerstochter aus der Poschenrieder Mühle in Bruckdorf.
Topography and clinical implication of Wormian bones on dry adult human skulls in Telangana region
Authors: Chelli Sudhakara Babu , N. Bhimai Devi , P. Anuradha , K. Mohana Sandhya , K. Bhaskar 
Published: November 2023

Introduction and Aim: Wormian bones vary in size, form and quantity and their occurrence is influenced by both genetic and environmental variables. Wormian bones are also seen in foetus ultrasounds during the antenatal period. The occurrence of much more than one sutural bone at the pterion is radiographically significant. The current study aims at the occurrence and topography of Wormian bones in the Telangana region and correlates them to other population groups.

Material and Methods: This study was carried out in 160 dry adult human skulls. Presence of these Wormian bones in sagittal, coronal, and Lambdoid sutures along with bregma, lambda, asterion and pterion were noted. The quantitative data is analyzed, and the images were captured.

Results: Their incidence was 45 % while in 55% skulls they were absent. Their percentage was more in lambdoid suture (16.9%) followed by asterion (12.5%). They were also observed in sutures like coronal (5.6%) and sagittal (1.9%). In pterion their occurrence was 3.12%. In bregma, none of the skull showed Wormian bones.

Conclusion: In the present study, incidence of Wormian bones (Wb’s) is 45% with a greater number of Wb’s observed in Lambdoid suture (16.9%). In the event of any interventions or investigations on the skull, topography of these bones is to be considered.
Ethanolic extract of Muntingia calabura L. as an antihypercholesterolemic by reducing malondialdehyde (MDA) levels in white mice (Mus musculus)
Authors: Lidesna Shinta Amat Anita , Pieter Louis Wungouw Herman , Meliyuita Br Damanik Efrisca , Pakan Prisca , Indriarini Desi 
Published: November 2023

Introduction and Aim: A diet high in cholesterol causes hypercholesterolemia by elevating plasma cholesterol levels. Hypercholesterolemia causes an increase in cholesterol concentration within cells, resulting in membrane-altering lipid peroxidation. Malondialdehyde (MDA) is produced during lipid peroxidation to form peroxides and other free radicals. The present study aims to evaluate the potential of Muntingia calabura L. ethanolic extracts as a hypercholesterolemia agent by reducing MDA levels in hypercholesterolemic white mice (Mus musculus).

Materials and Methods: The present study has a true experimental design with a control group consisting only of post-test samples. The research utilized approximately 25 white mice (Mus musculus) randomly. These white mice were separated into five groups, consists of negative control (C1), positive control (C2), M. calabura L. ethanolic extracts at doses of 13 mg/20g/BW (C3), 26 mg/20g/BW (C4), and 52mg/20g/BW (C5). The concentration of MDA was measured on the 21st day of treatment using the TBARS method.

Results: The results indicated that the M. calabura L. extracts significantly (p<0.05) reduce the total cholesterol and MDA levels in the blood of white mice (Mus musculus). The evidence supporting this conclusion is based on the data obtained from mice that received various doses of M. calabura L leaf extract, specifically 13mg/20g/BW, 26mg/20g/BW, and 52mg/20g/BW. These doses already demonstrated a substantial reduction in MDA levels following the treatment.

Conclusion: In this research, it was found that the ethanolic extract of M. calabura L leaves effectively acted as an anti-hypercholesterolemic agent in mice with hypercholesterolemia. The assessment of its anti-hypercholesterolemic properties was based on the observation of reduced MDA levels. It is suggested that the leaf extract of M. calabura L contains a compound known as phytol, which is believed to have the capacity to inhibit hypercholesterolemia in white mice (Mus musculus).
An integrative approach to panuveitis- A case report
Authors: K. Shanti , G. Gopinathan 
Published: November 2023

Uveitis is one of the major causes of blindness in the world. The International Uveitis Study Group (IUSG) defines panuveitis as a generalized inflammation of all three uveal organs (iris, ciliary body, and vitreous humour) based on anatomical location. The standard line of management of panuveitis involves the use of Immunosuppressive drugs, steroid therapy and NSAIDs. We describe how an integrative approach can help a patient with bilateral panuveitis become less dependent on immunosuppressive medications. A 55-year-old female, diagnosed with bilateral panuveitis sought Ayurvedic treatment after being dependent on steroids for 3 years. She was managed with internal medicines and external therapies for 4 years. During quarterly follow ups in this time, her immunosuppressive drugs, DMARD and NSAID were all gradually tapered and withdrawn. The frequency of acute phases of the disease was considerably reduced and her vision markedly improved to normalcy. There was also significant improvement in her overall health status. Integration of Ayurveda with the conventional treatment can reduce the dependence on immunosuppressive drugs and also improve the quality of life of the patient.
Physical and psychological symptom burden from long Covid and correlation with clinico-radiological and biochemical profile of hospitalized patients with acute COVID-19 due to Delta variant of SARS-CoV-2
Authors: Revendran Jayamol , Narasimhan Meenakshi 
Published: November 2023

Introduction and Aim: It is crucial to identify the burden of post COVID long-term morbidity denoted as long-COVID. Our study aims to determine prevalence of Long-COVID and to identify indicators which can predict chances of developing this condition. The aim was to study the persisting symptoms and predictors for long-COVID in COVID-19 patients.

Materials and Methods: All patients hospitalized with acute COVID-19 infection from 1st April 2021 to 30th June 2021 with a positive RT-PCR were followed up through telephonic interview after 6 months of discharge. All clinical, laboratory, radiological data of patients during their hospital admission was retrieved from medical records. Current physical and psychological symptom burden (PHQ2 score) was recorded using a structured questionnaire and analysed.

Results: Total of 101 patients were included. Mean age was 47yrs. M: F=2:1. Mean number of hospital stays was 7 days (1-34). Most patients needed admission on 5th day of illness (1-14). Mean CRP, D Dimer and Ferritin values were 77 mg/dl, 335 ng/ml, 414 microgram/ml respectively. Mean CT severity score was 12. The most common comorbidity was Type 2 Diabetes mellitus followed by hypertension. Of all patients, 16 % had symptoms of long COVID during 6 months post COVID infection. Most common symptoms were fatigue (60%), exercise intolerance (55%), cough (18%), breathlessness (18%), disturbed sleep quality (10%) and depression in 9.7% of patients as assessed by PHQ2 Score (1-6). None of the predictive factors were found to have statistically significant correlation with development of Long- COVID.

Conclusion: Of all patients hospitalised with COVID-19, 16 % had long COVID symptoms at 6 months assessment. Majority had fatigue and exercise intolerance but one tenth also had depression. Multispecialty COVID follow up clinics are necessary for further assessment and rehabilitation of these patients.