bluuebunny/crossref_metadata_2025_split huggingface dataset:
Guiding early revascularization using [15O]H2O positron emission tomography myocardial perfusion imaging: impact of atrial fibrillation
Authors: Madsen Simon , Kjaerulff Mette Louise Gram , Ejlersen June Anita , Ranghøj Nielsen Bent Roni , Jakobsen Lars , Sörensen Jens , Tolbod Lars Poulsen , Gormsen Lars Christian 
Published: February 2024

Abstract

Aims
Myocardial perfusion imaging (MPI) using [15O]H2O positron emission tomography (PET) is used to guide the selection of patients with angina for invasive angiography and possible revascularization. Our study evaluated (i) whether atrial fibrillation (AF) reduces global hyperaemic myocardial blood flow (MBF) and (ii) whether [15O]H2O PET MPI effectively guides revascularization procedures for patients with ongoing AF.

Methods and results
We prospectively recruited 346 patients with angina and persistent or paroxysmal AF referred for baseline/hyperaemic [15O]H2O PET MPI. The primary outcome was revascularization within 3 months of MPI. In the analyses, patients were divided into four groups based on whether they had ongoing AF or sinus rhythm (SR) and whether they had previously documented coronary artery disease (CAD) or not. Thus, four groups were compared: SR-noCAD, AF-noCAD, SR-CAD, and AF-CAD. Hyperaemic MBF was affected by both ongoing AF and prior CAD [MBF (mL/min/g): 2.82 (SR-noCAD) vs. 2.12 (AF-noCAD) vs. 2.22 (SR-CAD) vs. 1.80 (AF-CAD), two-way analysis of variance P &lt; 0.0001]. In multiple linear regression, ongoing AF was independently associated with reduced hyperaemic MBF. Every 0.1 mL/min/g decrease in hyperaemic MBF was associated with a 23% increase in odds of early revascularization. Receiver operating characteristic (ROC) analysis of vessel-specific hyperaemic MBF to predict early revascularization yielded the following areas under the ROC curve: SR-noCAD: 0.95 (P &lt; 0.0001); AF-noCAD: 0.79 (P &lt; 0.0001); SR-CAD: 0.78 (P &lt; 0.0001); and AF-CAD: 0.88 (P &lt; 0.0001).

Conclusion
Ongoing AF is associated with 19–25% reduced global hyperaemic MBF as measured by [15O]H2O MPI PET. Regardless, vessel-specific hyperaemic MBF still predicts early revascularization in patients with AF.
Assessment of suitability for percutaneous mitral commissurotomy: a contemporary review of key anatomical criteria and predictive models
Authors: Abdelghani Mohammad , Nunes Maria Carmo P , Anwar Ashraf M , Prendergast Bernard 
Published: February 2024

Abstract
The immediate result of percutaneous balloon mitral commissurotomy is largely determined by the anatomy of the mitral valve complex. Several scores and models have been developed to assess anatomical suitability for percutaneous balloon mitral commissurotomy. Although none has an optimal predictive power, these models look at the valvular apparatus from different perspectives bearing the potential for a complementary role.
Risk of Infective Endocarditis in Streptococcus mitis Bloodstream Infections Among Patients with Neutropenia from Hematologic Malignancies
Authors: Monk Miranda , Patel Nikitha R , Elshaboury Ramy , Kubiak David W , Hammond Sarah P 
Published: February 2024

Abstract
Streptococcus mitis commonly causes bloodstream infections (BSIs) in neutropenic patients but infrequently results in infective endocarditis (IE) in this population. Among 210 patients with neutropenia and S. mitis BSI, 55% underwent cardiac imaging. None were diagnosed with S. mitis IE; 3 had recurrent S. mitis BSI within 12 weeks.
The US–Japan alliance and the role of the US Marines on Okinawa in extended deterrence
Authors: O’Shea Paul 
Published: February 2024

Abstract
The relocation of the controversial Marine base at Futenma on Okinawa to Henoko in the north of the same island has been framed by Japanese politicians, officials, and analysts as crucial to deterrence. Critics respond that deterrence is merely a pretext, and the relocation is a politically convenient solution that perpetuates discrimination against Okinawa by the central government in Tokyo. This article draws on deterrence theory to evaluate the deterrence claims made by relocation proponents. It finds little evidence to support them: the Marines’ capabilities pale against the massive US forward deployment, including the Seventh Fleet and the Fifth Air Force. As for the local balance of forces, the Marines are unlikely to participate immediately in a local conflict, and their geographical location leaves them vulnerable; current US strategy is to down-scale and disperse Marine units. If one were focusing on defence rather than political convenience, the Marines would be relocated off Okinawa. In terms of credibility, the article finds that other US bases in Japan play a much more important ‘tripwire’ role, and ultimately, given inter alia the security treaty, joint exercises, and deep interoperability, US extended deterrence to Japan is as credible as possible under the circumstances.
Determination of Incidence and Risk Factors of Medical Device-Related Pressure Injury in the ICU: A Descriptive Study
Authors: Dirgar Ezgi , Gider Neslihan Yağmur , Tosun Betül 
Published: February 2024

ABSTRACT

OBJECTIVE
To determine the incidence and risk factors of medical device-related pressure injury (MDRPI) in the ICU.

METHODS
In this descriptive study, the researchers collected data through systematic observation of patients (n = 58) in the ICU. The patients were evaluated within 24 hours of ICU admission and then followed up until they were discharged. A total of 482 patient-days were followed. The researchers used the MDRPI follow-up form, the patient descriptive form, the MDRPI follow-up form, and the Braden Scale for Predicting Pressure Sore Risk for data collection.

RESULTS
Overall, 39.7% of the 58 patients hospitalized in the ICU developed an MDRPI, and 5.2% of the MDRPIs were evaluated as stage 2. These injuries occurred in an average of 5 days after the patient was admitted to the ICU. Among the MDRPIs that developed, 31.9% were located in the nose, 21.3% in the mouth, and 14.9% on the cheeks. Intubation tubes were used in 7.3% of the patients, nasogastric tubes in 22.4% of the patients, and radial artery catheters in 10.5% of the patients.

CONCLUSIONS
The development of MDRPI is correlated with the type of medical device used. Providers should establish a planned care protocol based on the anatomic placement of the medical device and take necessary precautions to prevent MDRPI.
Platelet-Rich Plasma: Advances and Controversies in Hair Restoration and Skin Rejuvenation
Authors: Kourosh Arianne Shadi , Santiago Mangual Kathyana P. , Farah Ronda S. , Rao Medha , Hordinsky Maria K. , Arruda Suleima , Sadick Neil 
Published: February 2024

BACKGROUND
Platelet-rich plasma (PRP) and its combined therapeutic modalities have catalyzed new possibilities in dermatology; however, limitations in evidence and lack of consensus remain among clinicians regarding optimal composition, protocol, technique, and application.

OBJECTIVE
To provide an update and analysis of the evidence for PRP in hair restoration and skin rejuvenation through review of recent available data, highlighting controversies and expert insights to guide future studies, and stimulate discourse and innovations benefitting patients.

METHODS
A structured review and expert analysis of PubMed publications before October 2023, with a focus on recent literature from January 2020 through October 2023.

RESULTS AND CONCLUSION
Growing literature supports the utility and benefits of PRP and related autologous products for applications for skin and hair, with strongest evidence for androgenetic alopecia and skin rejuvenation. However, this is limited by lack of consensus regarding best practices and protocols. Randomized, controlled trials with uniform metrics comparing outcomes of various compositions of autologous blood products, preparation methods, dosimetry, and frequency of treatments are still required. This will allow the medical discourse to grow beyond the realm of expert opinion into consensus, standardization, and more wide spread adoption of best practices that will benefit patients.
Assessing Pharmacokinetic Correlates of Escitalopram-Related Adverse Drug Reactions
Authors: Kuzin Maxim , Haen Ekkehard , Kuzo Nazar , Endres Katharina , Hiemke Christoph , Paulzen Michael , Schoretsanitis Georgios 
Published: February 2024

Background:
To assess the pharmacokinetic correlates of reported adverse drug reactions (ADRs) under antidepressant treatment with escitalopram (ESC) using a large therapeutic drug monitoring database.

Methods:
A large naturalistic sample of inpatients and outpatients prescribed ESC was analyzed. ADRs were classified using the Udvalg for Kliniske Undersogelser side effect rating scale. We compared ESC-treated patients with (n = 35) and without ADRs (n = 273) using ESC plasma concentrations as the primary outcome. We also compared ADR rates in the 2 groups based on 2 cut-off ESC levels reflecting the recommended upper thresholds of the therapeutic reference range of 80 ng/mL, suggested by the consensus therapeutic drug monitoring guidelines, and 40 ng/mL, based on recent meta-analysis data. The effects of age, sex, smoking, daily ESC dose, plasma concentrations, and concentrations corrected for daily dose were included in a binary logistic regression model to predict ADRs.

Results:
No differences in clinical, demographic, or pharmacokinetic parameters were observed between patients with and without ADRs (P > 0.05). Patients with ESC-related ADRs were more frequently diagnosed with psychotic disorders than those without (25% vs. 7.1%, P = 0.004). None of the variables was associated with ADR risk. Overall, ADR rates were not significantly different in patients above versus below thresholds of ESC concentrations (ESC concentrations >40 [n = 59] vs. ≤40 ng/mL [n = 249] and >80 [n = 8] vs. ≤80 ng/mL [n = 300]; P = 0.56 and P = 1.0, respectively).

Conclusions:
No distinct pharmacokinetic patterns underlying ESC-associated ADRs were observed. Further studies with more specific assessments of ADRs in larger cohorts are required to better identify potential underlying patterns.
Health Care Students' Perceptions of Bias During Their Clinical Training and Insights on Mitigating It
Authors: Parvez Mehnaz , Barnes Lisa , Gonzalez Rebecca , Prestegaard Keanna , Rick Tara J. 
Published: February 2024

Purpose
To understand health care students' perception of implicit bias and examine their insights to create a bias-free training environment.

Methods
Clinical phase students from one university's 4 health care programs participated in this study. Students were surveyed regarding their knowledge of implicit bias and perception of their experiences in the clinical learning environment.

Results
The response rate was 50.9%, N = 161. In total, 52.6% reported having prior training on implicit bias, and 55% self-reported that they had personally observed preceptors who exhibited an implicit bias toward patients based on race, ethnicity, or other qualities. There was no statistically significant relationship between those with prior training on implicit bias and being able to identify implicit bias exhibited by preceptors. Participants also expressed their unwillingness to report an incident unless it is confidential due to fear of retribution.

Conclusion
This study found that health care students from one university's 4 health care programs perceived implicit bias in their clinical learning environment, which they believe could be improved by taking intentional steps. Some suggestions provided were “Safe space to report and openly discuss bias,” “Education/training on implicit bias,” “Time for self-reflection,” and “Hiring process that evaluates/trains against implicit bias.” The implication of our study is to create a bias-free training environment that will help interrupt the propagation of biases contributing to health disparity. Further research should examine a national population and identify interventional methods and outcomes in multiple health care disciplines.
Global research status and frontiers on autophagy in hepatocellular carcinoma:a comprehensive bibliometric and visualized analysis
Authors: He Tao , Zou Jieyu , Sun Ke , Yang Juan 
Published: February 2024

Background:
An extensive body of research has explored the role of autophagy in hepatocellular carcinoma (HCC), revealing its critical involvement in the disease’s pathogenesis, progression, and therapeutic targeting. However, there is a discernible deficit in quantitative, analytical studies concerning autophagy in the context of HCC. Accordingly, this investigation endeavored to meticulously assess the evolution of autophagy research, employing bibliometric citation analysis to offer a comprehensive evaluation of the findings in this field.

Methods:
We conducted a literature search on August 2, 2023, to extract relevant publications spanning from 2013 to 2022, indexed in the Science Citation Index-Expanded (SCIE) of the Web of Science Core Collection (WOSCC). Subsequently, we performed a bibliometric assessment of the compiled documents using visualization tools such as CiteSpace and VOSviewer.

Results:
The search yielded 734 publications penned by 4,699 authors, encompassing contributions from 41 countries and 909 institutions, disseminated across 272 journals, and comprising 26,295 co-cited references from 2,667 journals. Notably, China led in publication volume with 264 articles (amounting to 35.9%) and exhibited the most robust collaboration with the United States. The mechanisms underlying autophagy’s influence on the emergence and advancement of HCC, as well as the implicated proteins and genes, have garnered significant attention. In recent years, investigations of targeting autophagy and the resistance to sorafenib have surfaced as pivotal themes and emerging frontiers in this domain.

Conclusion:
This study rigorously collated and distilled the prevailing research narratives and novel insights on autophagy in HCC. The resultant synthesis provides a substantive foundation for medical professionals and researchers, as well as pivotal implications for future investigative endeavors in this arena.
18F-FDG PET/CT in a Case of Clear Cell Sarcoma of the Kidney
Authors: Jin Hongfu , Yin Yafu , Wang Hui , Cheng Weiwei 
Published: February 2024

Abstract

18F-FDG PET/CT was performed in a 1-year-old girl who had a heterogeneous mass in the right abdominal cavity revealed by abdominal ultrasound. A heterogeneous mass with internal necrosis, cystic changes, and hemorrhage in the right kidney, accompanied by a slight increase of FDG uptake, was observed in FDG PET/CT. Malignant renal tumor was considered, and Wilms tumor was preferentially suspected. However, the mass was demonstrated as clear cell sarcoma of the kidney by histopathological examination.
Role of flow structures on the deposition of low-inertia particles in turbulent pipe flow
Authors: Schlander Rasmus Korslund , Rigopoulos Stelios , Papadakis George 
Published: February 2024

We analyze the effect of large-scale coherent structures on the deposition of low-inertia particles in a turbulent pipe flow using extended proper orthogonal decomposition (EPOD) and spectral analysis. We perform direct numerical simulations (DNSs) at two the Reynolds numbers 5300 and 10 300 (based on bulk parameters) with the particles released at the pipe inlet. The equilibrium Eulerian model is employed for calculating particle velocity, and the analysis is limited to particles with Stokes number (based on wall units) less than 1. Increasing the Stokes number increases the energy at small streamwise wavelengths (due to inertial clustering), and the spectral energy peak moves from λz+≈1000 to λz+≈150. The spectral peak in the (λz+,y+) plane, where y+ is the wall-normal distance, moves from the buffer layer to the logarithmic region. Gravity has a substantial effect on the POD mode shapes. For the downward flow, a second peak appears closer to the center. A new Fukagata-Iwamoto-Kasagi (FIK) identity is derived for the wall deposition rate coefficient (Sherwood number, Sh) and employed to quantify the contributions of the mean and fluctuating velocity and particle concentration fields for different Stokes, Froude, and Reynolds numbers. Modes with azimuthal wave numbers kθ equal to three or four are found to contribute most to deposition. Application of the developed methodology to higher Reynolds number can elucidate the role of large- and very-large-scale flow structures on particle deposition to the wall. It is well known these structures leave their footprint at the wall but their contribution to deposition is not well understood.

Published by the American Physical Society
2024
Investigation of the
6s6p P03−4f135d6s2
(
J=2
) Clock Transition in
Yb171
Atoms
Authors: Qiao Hao , Ai Di , Sun Chang-Yue , Peng Cheng-Quan , Qi Qi-Chao , Zhao Cheng-Cheng , Luo Li-Meng , Jin Tao-Yun , Zhang Tao , Zhou Min , Xu Xin-Ye 
Published: February 2024

High-precision atomic spectroscopy provides an invaluable and sensitive tool for exploring a wide range of physical questions. Here, we investigate the forbidden optical transition of the 6s6pP30−4f135d6s2 (J=2) in Y171b atoms at the wavelength of 1695 nm, which exhibits the highest sensitivity to the variation of the fine-structure constant α compared to the current neutral optical clock. We obtain high-resolution transition spectroscopy in a one-dimensional optical lattice, and the measurement of its absolute frequency achieves kHz-level accuracy. Meanwhile, several essential atomic constants are also determined, including the electric-dipole (E1) magic wavelengths, as well as the hyperpolarizabilities and tensor polarizabilities around the E1 magic wavelengths. Additionally, we derive the hyperfine constant for the J=2 state from the measured absolute frequencies 1123 252.3±2.0  kHz, providing a sixfold enhancement in the uncertainty reduction compared to the recent result. We anticipate that this work will prompt further investigation of the additional clock transition at 1695 nm in Y171b atoms. Together with the well-established S01−P03 transition, many fundamental and new physics research, such as the time variation of α, ultralight dark-matter searches, Lorentz violation, etc., will enable new bounds and measurements with unprecedented precision.

Published by the American Physical Society
2024
Artificial intelligence in entrepreneurship education: a scoping review
Authors: Chen Li , Ifenthaler Dirk , Yau Jane Yin-Kim , Sun Wenting 
Published: February 2024

PurposeThe study aims to identify the status quo of artificial intelligence in entrepreneurship education with a view to identifying potential research gaps, especially in the adoption of certain intelligent technologies and pedagogical designs applied in this domain.Design/methodology/approachA scoping review was conducted using six inclusive and exclusive criteria agreed upon by the author team. The collected studies, which focused on the adoption of AI in entrepreneurship education, were analysed by the team with regards to various aspects including the definition of intelligent technology, research question, educational purpose, research method, sample size, research quality and publication. The results of this analysis were presented in tables and figures.FindingsEducators introduced big data and algorithms of machine learning in entrepreneurship education. Big data analytics use multimodal data to improve the effectiveness of entrepreneurship education and spot entrepreneurial opportunities. Entrepreneurial analytics analysis entrepreneurial projects with low costs and high effectiveness. Machine learning releases educators’ burdens and improves the accuracy of the assessment. However, AI in entrepreneurship education needs more sophisticated pedagogical designs in diagnosis, prediction, intervention, prevention and recommendation, combined with specific entrepreneurial learning content and entrepreneurial procedure, obeying entrepreneurial pedagogy.Originality/valueThis study holds significant implications as it can shift the focus of entrepreneurs and educators towards the educational potential of artificial intelligence, prompting them to consider the ways in which it can be used effectively. By providing valuable insights, the study can stimulate further research and exploration, potentially opening up new avenues for the application of artificial intelligence in entrepreneurship education.
What if ChatGPT generates quantitative research data? A case study in tourism
Authors: Sop Serhat Adem , Kurçer Doğa 
Published: February 2024

Purpose
This study aims to explore whether Chat Generative Pre-training Transformer (ChatGPT) can produce quantitative data sets for researchers who could behave unethically through data fabrication.

Design/methodology/approach
A two-stage case study related to the field of tourism was conducted, and ChatGPT (v.3.5.) was asked to respond to the first questionnaire on behalf of 400 participants and the second on behalf of 800 participants. The artificial intelligence (AI)-generated data sets’ quality was statistically tested via descriptive statistics, correlation analysis, exploratory factor analysis, confirmatory factor analysis and Harman's single-factor test.

Findings
The results revealed that ChatGPT could respond to the questionnaires as the number of participants at the desired sample size level and could present the generated data sets in a table format ready for analysis. It was also observed that ChatGPT's responses were systematical, and it created a statistically ideal data set. However, it was noted that the data produced high correlations among the observed variables, the measurement model did not achieve sufficient goodness of fit and the issue of common method bias emerged. The conclusion reached is that ChatGPT does not or cannot yet generate data of suitable quality for advanced-level statistical analyses.

Originality/value
This study shows that ChatGPT can provide quantitative data to researchers attempting to fabricate data sets unethically. Therefore, it offers a new and significant argument to the ongoing debates about the unethical use of ChatGPT. Besides, a quantitative data set generated by AI was statistically examined for the first time in this study. The results proved that the data produced by ChatGPT is problematic in certain aspects, shedding light on several points that journal editors should consider during the editorial processes.
Consumer behavior in Islamic banking: a systematic literature review and agenda for future research
Authors: R.V. ShabbirHusain , Annamalai Balamurugan , Chandrasekaran Shabana 
Published: February 2024

Purpose
This study aims to conduct a systematic literature review on consumer behavior (CB) in Islamic banking (IB), encompassing an overview of researched contexts and topics, identifying literature gaps and proposing a comprehensive future research agenda.

Design/methodology/approach
By using bibliometric citation and content analysis, this study investigates 135 documents sourced from Scopus indexed publications.

Findings
This study delves into the growing field of CB in IB, offering a comprehensive understanding that encompasses influential journals, theories, research context, characteristics and methods used in IB research.

Originality/value
To the best of the authors’ knowledge, this study is the first to provide a comprehensive review of CB studies in the IB domain detailing research topics, prevailing theories, research settings, important variables and research methods.