bluuebunny/crossref_metadata_2025_split huggingface dataset:
Synthesis and Oxygen Evolution Reaction Application of a Co−Cd Based Bimetallic Metal‐Organic Framework
Authors: Shah Syed Shaheen , Albadrani Ahmed , Fettouhi Mohammed , Aziz Md. Abdul , Helal Aasif 
Published: February 2024

AbstractIn the realm of renewable energy technologies, the development of efficient and durable electrocatalysts is paramount, especially for applications like electrochemical water splitting. This research focuses on synthesizing a novel bimetallic metal‐organic framework (BMMOF11) using earth‐abundant elements, cobalt (Co) and cadmium (Cd). BMMOF11 showcases a distinctive structure with distorted octahedral chains of CoO and CdO, linked by benzene tricarboxylic acid (BTC). Our study primarily investigates the electrocatalytic efficiency of BMMOF11, particularly in water oxidation reactions. For practical analysis, BMMOF11 was anchored onto nickel foam, forming BMMOF11/NF, to evaluate its electrocatalytic properties. Electrochemical testing revealed that BMMOF11/NF begins water oxidation at an onset potential of 1.62 V versus RHE, demonstrating high activity with a lower overpotential of 0.4 V to achieve a current density of 10 mA/cm2. Moreover, BMMOF11/NF maintained stable water splitting performance, sustaining a current density of approximately 70 mA/cm2 under a voltage of 1.9 V relative to RHE. These findings indicate that BMMOF11/NF is a promising candidate for large‐scale electrochemical water splitting, offering a blend of high activity and stability.
Role of Halobenzene Guest Molecules in Modulating Room Temperature Phosphorescence of Benzophenone–Naphthalene Diimide Inclusion Crystals
Authors: Tsukiyama Yoshifumi , Yamamoto Yusei , Koga Daiki , Cui Luxia , Hoshino Yu , Hisaeda Yoshio , Ono Toshikazu 
Published: February 2024

AbstractMaterials exhibiting room temperature phosphorescence (RTP) have recently emerged as a subject of significant interest. In this study, we successfully created inclusion crystals by introducing halobenzenes as guests into a host molecule combining benzophenone with naphthalene diimide. This approach led to the creation of fascinating fluorescence and RTP properties dependent on the guest molecules. Notably, crystals containing chlorobenzene showed cyan fluorescence, while those with iodobenzene displayed red RTP. This difference highlights the impact of the guest molecule on the luminescent properties, with the significant external heavy‐atom effect of iodobenzene playing a key role in promoting efficient intersystem crossing between the excited singlet and triplet states. Crystals with bromobenzene exhibited a unique blend of fluorescence and RTP, both from benzophenone and naphthalene diimide, highlighting the moderate heavy‐atom effect. These findings reveal composite materials with remarkably diverse and interesting optical characteristics.
Prenatal exposure to pesticide mixture in Argentina: A pilot study in puerperal women from Santa Fe province
Authors: Colussi Carlina Leila , Martinez Guillaume , Bellenger Jean‐Philippe , Poletta Gisela Laura , Simoniello María Fernanda 
Published: February 2024

AbstractIntroductionThe epidemiological investigation of congenital anomalies (CA) represents a challenge due to the multiplicity of associated risk factors, notably environmental ones. The monitoring of genotoxic effects in different populations is a useful tool in human biomonitoring and has great biological importance in estimating the exposure risks to complex mixtures of chemical substances.ObjectiveThis study aimed to determine the presence of environmental xenobiotics and evaluate their genotoxic effect, in mothers of newborns with and without CA, and the possible association/correlation between those biomarkers and CA.Materials and methodsA descriptive case and control cross‐sectional study was developed on 290 postpartum women from Santa Fe, Argentina.ResultsSignificant differences were observed between both groups, for places of residence and gynecological variables. Metabolites of organochlorine (OC), organophosphate (OP), and pyrethroid (PYR) pesticides were detected. The most frequently detected compounds were atrazine (ATZ) (57.14%), carbendazim (CBZ) (46.42%), and methylparaben (46.42%), among others. A positive correlation was found between the number of pesticides in blood and genotoxic variables. On the other hand, mothers of children with genitourinary anomalies were the ones with the highest concentrations of ATZ and OP.Discussion and conclusionThese results showed a deep background in the health reality of Santa Fe, which could greatly impact the health of future adults, who have been born preterm. On the other hand, the mixture of pesticides detected confirms the environmental living conditions of women and the transplacental exposure to these compounds in each pregnancy. The potential effects on long‐term descendent health are unknown and unpredictable.
Virtual schools for care‐experienced learners in Scotland: Reflections on an emerging concept in a new context
Authors: McIver Leanne , Bettencourt Michael 
Published: February 2024

AbstractThe ‘virtual school’ is an approach to supporting care‐experienced children and young people in education. The Virtual School Head (VSH) has been a statutory role within the education landscape in England since 2014. In Scotland, where the education, social care and legal systems are distinct from those in England, there has been a recent increase in the number of local authorities utilising this concept. This research aimed to explore the role and remit of Virtual School Head Teachers (VSHTs) in Scotland, and to identify similarities and differences with those of VSHs in England, to uncover learning about the emergence of this concept and role in a new context. We conducted semi‐structured interviews with relevant post‐holders in Scotland, using key concepts from the published literature on virtual schools in England, and analysed these qualitatively to identify themes. We discuss some of the similarities and differences we identified, noting that while the purpose of the role, and the means by which it functions, were largely common to both countries, there were also nuanced differences. Key similarities included the importance of positioning within the local authority, and the development of relationships with social work. Differences were largely underpinned by the educational and legal contexts in which the post‐holders operated, and included control of budgets and specificity of remit. This research contributes to our understanding of the role of the VSHT in Scotland, and identifies some emerging features as the virtual school concept is translated to a new context.
Einfluss einer Wärmebehandlung auf das Verbundkriechen von hochfestem Beton
Authors: Schwarz Yannik , Sanio David , Mark Peter 
Published: February 2024

AbstractDie Verbundwirkung von Beton und Betonstahl ermöglicht es, Kräfte zwischen den beiden Baustoffen zu übertragen. An der mechanischen Verzahnung der Rippen mit dem umliegenden Beton entstehen dabei hohe Druckspannungen auf die Betonkonsolen. Dies führt bei Dauerlast zu Kriechverformungen (Verbundkriechen). Die Relativverschiebung (Schlupf) zwischen Bewehrungsstab und Beton nimmt dabei stetig zu, was sich nachteilig auf Rissbreiten und Dauerhaftigkeit auswirken kann. Im Beitrag wird die Reduktion des Verbundkriechens durch eine initiale rapide Wärmebehandlung bei 80 °C mit 60 % relativer Luftfeuchte und Dauern von 4, 16 oder 24 h experimentell untersucht. Hierfür werden Probekörper aus hochfestem Beton – im Anschluss an die entsprechende Wärmebehandlung – im Auszugsversuch für 300 d mit einer konstanten Dauerlast beaufschlagt und der kontinuierliche Anstieg der Relativverschiebungen aufgezeichnet. Als Referenz dienen nicht temperierte Proben. Die Kriechverformungen werden anhand von unbelasteten Proben von den Schwindeffekten separiert. Zudem werden unerwünschte Biegeeffekte aus der unvermeidlichen Vorkrümmung der Betonstähle identifiziert und rechnerisch eliminiert. Die Ergebnisse zeigen, dass durch die Wärmebehandlung das Verbundkriechen um etwa 40 % geringer ausfällt.
Crocus sativus tepals extract suppresses subcutaneous adipose tissue hypertrophy and improves systemic insulin sensitivity in mice on high‐fat diet
Authors: Bursać Biljana , Bellachioma Luisa , Gligorovska Ljupka , Jovanović Mirna , Teofilović Ana , Vratarić Miloš , Vojnović Milutinović Danijela , Albacete Alfonso , Martínez‐Melgarejo Purificación A. , Morresi Camilla , Damiani Elisabetta , Bacchetti Tiziana , Djordjevic Ana 
Published: February 2024

AbstractObesity is a pressing problem worldwide for which standard therapeutic strategies have limited effectiveness. The use of natural products seems to be a promising approach to alleviate obesity and its associated complications. The tepals of Crocus sativus (Cr) plant, usually wasted in saffron production, are an unexplored source of bioactive compounds. Our aim was to elucidate the mechanisms of Cr tepals extract in obesity by investigating its effects on adipocyte differentiation, visceral adipose tissue (VAT) and subcutaneous adipose tissue (SAT) hypertrophy, and lipid metabolism in an animal model of diet‐induced obesity. To this end, mouse 3T3‐F442A preadipocytes were treated with Cr tepals extract and the expression of adipocyte differentiation genes was determined. Caloric intake, body mass, triglycerides, systemic insulin sensitivity, histology, insulin signaling, and lipid metabolism in VAT and SAT were analyzed in mice fed a 60% fat diet for 14 weeks and treated orally with Cr tepals extract during the last 5 weeks of the diet. We demonstrated for the first time that Cr tepals extract inhibits adipocyte differentiation in vitro. The animal model confirmed that oral treatment with Cr tepals extract results in weight loss, improved systemic insulin sensitivity, lower triglycerides, and improved lipid peroxidation. The suppressive effect of Cr tepals extract on adipocyte hypertrophy and inflammation was observed only in SAT, which, together with preserved SAT insulin signaling, most likely contributed to improved systemic insulin sensitivity. Our results suggest the functionality of SAT as a possible target for the treatment of obesity and its complications.
Digitalisation and environmental management activities: The effects of family ownership`
Authors: Issah Wunnam Basit , Ferdous Lutfa Tilat , Bhuiyan Faruk , Sharif Taimur 
Published: February 2024

AbstractWhile digitalisation has significant implications for environmental management activities, this nexus has received minimal attention in research. Given this backdrop, this study uses a unique survey dataset of 386 micro and small enterprises (MSEs) and conducts an OLS regression analysis to examine the impact of digitalisation on environmental management activities. The study also investigates how family ownership moderates this relationship. The study finds that digitalisation supports environmental management activities as an important strategic mechanism, and that family ownership has a negative moderating effect on the relationship between digitalisation and environmental management activities. This study contributes to ‘institutional theory’ by highlighting its applicability to the new context of MSEs in emerging markets. Further, the study provides managerial insights into how to ensure environmental management practices in the digital age.
Finite element analysis megatrends: A road less traveled
Authors: Patil Arun Y. , Kundu Tanmay , Kumar Raman 
Published: February 2024

AbstractIn today's environment, finite element analysis is crucial for Mechanical Engineers. In today's highly competitive industries, graduates need to be productive from Day one as they enter the industry. To meet the vast range of industrial requirements or even for higher education, education institutes must adhere to an industry enabled curriculum as defined in collaboration with industry employees. As students reach their prefinal year of mechanical engineering studies, they will encounter courses like finite element analysis, design of machine elements, and failure analysis in design, which will serve as foundation steps for their future careers. As students need to compete in the real world, it becomes imperative to have a thorough understanding of both theoretical and practical issues. The focus of current work is to provide them a platform to think as a real‐time problem‐solving engineer to address the society‐based problems and how he/she approaches the problem in an optimized way and finally, convert the entire work to tangible documents in the form of research articles. Since 2018, a new vertical called as “advanced computer aided engineering (CAE)” has emerged to link and prepare people for the business. In the realm of finite element method (FEM) theoretical and allied laboratory work, the current study discusses sustainability while selecting the problem statement. The entire emphasis is on eco‐environment with nature's sustainability along with the go‐green concept in terms of materials, design, optimization, cost, quality, and so on. The present work includes several new features that were not present in the previous curriculum, such as transforming the work to high‐quality journals, student feedback, subscription‐based journal selection for the manuscript, and embedding experimental and analytical work alongside simulation studies. This time, 40 teams participated, with around 36 project works being qualified for publication in prestigious journals and 8–10 works being filed for Indian patents. In terms of quality and quantity of work completed, this is the best output attained in contrast to previous iterations. Because of the increasing growth rate of higher education, our students have been able to get into Top 100 QS ranked universities. The figures show that because of faculty involvement in the FEM lab, Advanced CAE I, and Advanced CAE II, over the previous 4–5 years, students were able to publish more than 50 publications in prestigious peer‐reviewed International/National Journals and Conference papers.
Comparison of IL‐2‐antibody to IL‐2‐Fc with or without stereotactic radiation therapy in CEA immunocompetent mice with CEA positive tumors
Authors: Williams Lindsay , Li Lin , Yazaki Paul J. , Wong Patty , Hong Teresa , Poku Erasmus K. , Hui Susanta , Ghimire Hemendra , Shively John E. , Kujawski Maciej 
Published: February 2024

AbstractBackgroundThe potent immune effects of interleukin‐2 (IL‐2) for cancer therapy can be increased by genetic fusion of IL‐2 to the Fc domain of an antibody (IL‐2‐Fc) or tumor targeted by genetic fusion to a whole antibody known as an immunocytokine (ICK).MethodsAn anti‐CEA ICK (M5A‐IL‐2) was compared to an IL‐2‐Fc fusion protein using tumor therapy and PET imaging in CEA transgenic immunocompetent mice bearing CEA positive colon or breast tumors. Combination with stereotactic radiation therapy (SRT) was performed with either ICK or IL‐2‐Fc.ResultsICK and IL‐2‐Fc had comparable antitumor effects in both tumor models, although ICK had higher tumor uptake and slower blood clearance than an IL‐2‐Fc. Analysis of IFNγ+/CD8+ and FoxP3+/CD4+ T cells revealed higher levels of IFNγ‐producing CD8+ T cells in ICK treated mice versus more efficient Treg elimination in IL‐2‐Fc treated mice. No significant or lasting toxicity was detected for either agent. Combination therapies with SRT revealed comparable efficacy and induction of immune memory for both ICK and IL‐2‐Fc when mice were rechallenged post‐therapy.ConclusionsIL‐2‐Fc had comparable antitumor efficacy to CEA‐targeted M5A‐IL‐2 ICK, while both fusion proteins induced immune memory when combined with SRT. Differences in the therapeutic mechanisms of both agents were observed.
Experiences of caregivers of children with cancer in Malawi: A qualitative study
Authors: Phiri Lophina , Li William Ho Cheung , Phiri Patrick G. M. C. , Cheung Ankie Tan , Wanda‐Kalizang'oma Watipaso , Kamwendo Anizia , Lemon Sellina 
Published: February 2024

AbstractBackgroundStudies have shown that caregivers of children with cancer experience challenges when caring for their children. To date, no studies have examined the experience of caregivers of children with cancer in Malawi, a low‐income country in sub‐Saharan Africa. Hence, this study aimed to explore the experiences of caregivers of Malawian children receiving cancer treatment.MethodsThis explorative qualitative study used semi‐structured interviews to collect data from 22 caregivers of children receiving cancer treatment. The data were analysed using qualitative content analysis.ResultsFive themes emerged from the QCA. The caregivers perceived their children's cancer as a burden, a form of psychological torture and a disruptor of family routines and social lifestyles. They also reported self‐isolation due to the stigma that they faced in the course of caring for their children and a need for informational, psychosocial, spiritual and financial support.ConclusionCaregivers of Malawian children with cancer experience physical and psychosocial challenges as they are caring for their children with cancer. Developing appropriate interventions would enable nurses to offer optimal support to these caregivers in dealing with these challenges and meeting their needs effectively.
Novel Bis(2‐cyanoacrylamide) Linked to Sulphamethoxazole: Synthesis, DNA Interaction, Anticancer, ADMET, Molecular Docking, and DFT Studies
Authors: Ragheb Mohamed A. , Mohamed Fatma G. , Diab Hadeer M. , Ragab Mona S. , Emara Marwan , Elwahy Ahmed H. M. , Abdelhamid Ismail A. , Soliman Marwa H. 
Published: February 2024

AbstractIn the light of advancement and potential extensive use of medication design and therapy, new bis(cyanoacrylamides) incorporating sulphamethoxazole derivatives (7 a–7 f) were synthesized and confirmed by different spectral tools. In vitro anticancer activity towards different human cancer cells (HCT116, MDA‐MB‐231 and A549) was assessed using MTT assay. Among all derivatives, 4C‐ and 6C‐spacer derivatives (7 e and 7 f) had the most potent growth inhibitory activities against HCT116 cells with IC50 values of 39.7 and 28.5 μM, respectively. 7 e and 7 f induced apoptosis and suppressed migration of HCT116 cells. These compounds also induced a significant increase in caspase‐3 and CDH1 activities, and a downregulation of Bcl2 using ELISA. pBR322 DNA cleavage activities of cyanoacrylamides were determined using agarose gel electrophoresis. Furthermore, 7 e and 7 f showed good DNA and BSA binding affinities using different spectroscopic techniques. Furthermore, molecular docking for 7 e and 7 f was performed to anticipate their binding capabilities toward various proteins (Bcl2, CDH1 and BSA). The docking results were well correlated with those of experimental results. Additionally, density functional theory and ADMET study were performed to evaluate the molecular and pharmacokinetic features of 7 e and 7 f, respectively. Thus, this work reveals promising antitumor lead compounds that merit future research and activity enhancement.
Discovery of α‐Obscurine Derivatives as Novel Cav3.1 Calcium Channel Blockers
Authors: Wang Lei , Li Wen‐Yan , Yuan Zai‐Feng , Zhao Qin‐Shi 
Published: February 2024

AbstractVoltage‐gated calcium channels (VGCCs), particularly T‐type calcium channels (TTCCs), are crucial for various physiological processes and have been implicated in pain, epilepsy, and cancer. Despite the clinical trials of TTCC blockers like Z944 and MK8998, none are currently available on the market. This study investigates the efficacy of Lycopodium alkaloids, particularly as natural product‐based TTCC blockers. We synthesized eighteen derivatives from α‐obscurine, a lycodine‐type alkaloid, and identified five derivatives with significant Cav3.1 blockade activity. The most potent derivative, compound 7, exhibited an IC50 value of 0.19±0.03 μM and was further analyzed through molecular docking, revealing key interactions with Cav3.1. These findings provide a foundation for the structural optimization of Cav3.1 calcium channel blockers and present compound 7 as a promising lead compound for drug development and a tool for chemical biology research.
Prognostic impact of peripheral artery disease in patients with and without high bleeding risk undergoing percutaneous coronary intervention
Authors: Spirito Alessandro , Cohen Rebecca , Sartori Samantha , Vogel Birgit , Baber Usman , Pileggi Brunna , Smith Kenneth , Nicosia Danielle , Kamaleldin Karim , Farhan Serdar , Kini Annapoorna , Sharma Samin K. , Dangas George , Mehran Roxana 
Published: February 2024

AbstractBackgroundPeripheral artery disease (PAD) is associated with worse outcomes after percutaneous coronary intervention (PCI). The aim of this study was to assess the prognostic impact of PAD according to high bleeding risk (HBR) status.MethodsConsecutive patients undergoing PCI with drug‐eluting stent implantation at a tertiary‐care center (Mount Sinai Hospital) between 2012 and 2019 were stratified according to HBR and PAD status. The primary outcome was major adverse cardiac events (MACE), a composite of all‐cause death, myocardial infarction (MI), and stroke 1 year after PCI. Secondary outcomes included major bleeding.ResultsOut of 16,750 patients, 43% were HBR and 57% were no‐HBR. Within the two groups, PAD patients were 14% and 6%, respectively, and were more likely to have comorbidities and to undergo complex PCI than no‐PAD patients. Within the HBR group, PAD was associated with an increased risk of MACE (11.4% vs. 7.3%, hazard ratio [HR]: 1.59, 95% confidence interval [CI]: 1.27–1.99, p < 0.001) and a numerical nonsignificant increase of major bleeding (8.5% vs. 6.9%, HR: 1.25, 95% CI: 0.98–1.59, p = 0.066) as compared with no‐PAD. Among no‐HBR patients, rates of MACE and major bleeding were numerically but not significantly higher in the PAD group. After multivariable adjustment, PAD was no longer a predictor of adverse outcomes, irrespective of HBR status.ConclusionsAt 1‐year after PCI, PAD was associated with increased 1‐year risks of MACE in HBR patients. After adjustment for cardiovascular risk factors and comorbidities, the effect of PAD on adverse events was largely attenuated.
Delayed replantation of avulsed permanent maxillary central incisor: Case report with 6‐year follow‐up
Authors: Rai Amita , Koirala Bandana , Dali Mamta , Shrestha Sneha 
Published: February 2024

Key Clinical MessageReplantation should be attempted in any case of avulsion, be it immediate or delayed. Retention of the replanted tooth helps in preservation of adjacent alveolar bone. Despite the occurrence of replacement resorption, the tooth can stay healthy and functional in the arch for a longer duration.