bluuebunny/crossref_metadata_2025_split huggingface dataset:
Shigellosis outbreak among persons experiencing homelessness—San Diego County, California, October–December 2021
Authors: Ohlsen Elizabeth C. , Angel Kristen , Maroufi Azarnoush , Kao Annie , Victorio Maria J. , Cua Lynnie S. , Kimura Akiko , Vanden Esschert Kayla , Logan Naeemah , McMichael Temet M. , Beatty Mark E. , Shah Seema 
Published: October 2023

Abstract
During October 2021, the County of San Diego Health and Human Services Agency identified five cases of shigellosis among persons experiencing homelessness (PEH). We conducted an outbreak investigation and developed interventions to respond to shigellosis outbreaks among PEH. Confirmed cases occurred among PEH with stool-cultured Shigella sonnei; probable cases were among PEH with Shigella-positive culture-independent diagnostic testing. Patients were interviewed to determine infectious sources and risk factors. Fifty-three patients were identified (47 confirmed, 6 probable); 34 (64%) were hospitalised. None died. No point source was identified. Patients reported inadequate access to clean water and sanitation facilities, including public restrooms closed because of the COVID-19 pandemic. After implementing interventions, including handwashing stations, more frequent public restroom cleaning, sanitation kit distribution, and isolation housing for ill persons, S. sonnei cases decreased to preoutbreak frequencies. Improving public sanitation access was associated with decreased cases and should be considered to prevent outbreaks among PEH.
THE METRIC OPERATORS FOR PSEUDO-HERMITIAN HAMILTONIAN
Authors: WANG WEN-HUA , CHEN ZHENG-LI , LI WEI 
Published: October 2023

AbstractThe Hamiltonian of a conventional quantum system is Hermitian, which ensures real spectra of the Hamiltonian and unitary evolution of the system. However, real spectra are just the necessary conditions for a Hamiltonian to be Hermitian. In this paper, we discuss the metric operators for pseudo-Hermitian Hamiltonian which is similar to its adjoint. We first present some properties of the metric operators for pseudo-Hermitian Hamiltonians and obtain a sufficient and necessary condition for an invertible operator to be a metric operator for a given pseudo-Hermitian Hamiltonian. When the pseudo-Hermitian Hamiltonian has real spectra, we provide a new method such that any given metric operator can be transformed into the same positive-definite one and the new inner product with respect to the positive-definite metric operator is well defined. Finally, we illustrate the results obtained with an example.
Sulfentrazone crop safety and efficacy in cabbage and broccoli
Authors: Pineda-Bermudez Laura , Besançon Thierry E. , Sosnoskie Lynn M. 
Published: October 2023

AbstractIn 2021 and 2022, research was initiated at two locations to evaluate the efficacy and safety of sulfentrazone in transplanted cabbage and broccoli. Treatments included oxyfluorfen at 560 g ha−1 applied pretransplant (PRE-T), sulfentrazone applied at 116 or 233 g ha−1 PRE-T, and S-metolachlor applied at 715 g ha−1 immediately after transplanting (POST-T) followed by (fb) oxyfluorfen applied at 210 g ha−1 postemergence (POST) 14 d after planting (DAP). The weedy cover of nontreated plots averaged between 6% (14 DAP) and 72% (42 DAP); all herbicide-treated plots averaged less than 30% cover at 42 DAP. At 14 and 28 DAP, oxyfluorfen, S–metolachlor fb oxyfluorfen, and the high rate of sulfentrazone reduced total monocotyledonous and dicotyledonous weed densities by 62% and 100%, respectively, relative to the nontreated control. The density of hairy galinsoga (in New Jersey) and combined ladysthumb and prostrate knotweed (in New York) were reduced by 71% to 99%. Except for the low rate of sulfentrazone, all herbicide treatments reduced weed biomass at harvest by ≥88%. Crop injury varied in response to herbicide treatments or weed competition but was also affected by crop and location. Between 14 and 28 DAP, the greatest amount of stunting (22%) was noted in the S-metolachlor fb oxyfluorfen treatments at both locations. Averaged over treatments, greater stunting was observed in broccoli than in cabbage in New York, whereas stunting estimates were higher for cabbage in New Jersey. All treatments in New Jersey resulted in significantly increased cabbage yield and broccoli and cabbage head sizes relative to the nontreated controls. No yield difference was noted between herbicide treatments and the nontreated check in New York. Data derived from these studies will be used to enhance crop safety recommendations in northeastern U.S. production environments for sulfentrazone used PRE in transplanted cabbage and support a potential label for broccoli.
The genetic diversity and population structure of weedy rice in northeast Thailand accessed by SSR markers
Authors: Ponsen Monchita , Loasatit Kularb , Monkham Tidarat , Sanitchon Jirawat , Moung-ngam Peerapon , Chankaew Sompong 
Published: October 2023

AbstractThailand’s northeast (NE) region is an area of high-quality cultivated rice (Oryza sativa L.) production. However, an outbreak of weedy rice has recently spread throughout the region. Weedy rice is phenotypically and morphologically similar to cultivated rice, making identification difficult. The prospective management of weedy rice in the future will involve the study of its genetic diversity and population structure in this region. This study assesses the genetic diversity and population structure of 380 weedy rice samples in the northeast of Thailand through simple sequence repeat (SSR) markers. Thirty-one SSR markers generated 213 alleles with an average of 6.87 per locus and an overall genetic diversity of 0.723. Based on its geographic origin, weedy rice in the Southern NE are showed greater genetic diversity than that in the Central NE and Northern NE areas. The outcrossing rate in all regions was relatively high, with the highest being in the Southern NE at 9.769%. According to genetic distance analysis, the clustering of weedy rice samples in northeast Thailand was not associated with the geographic region. Neighbor-joining and principal coordinate analysis revealed that the 380 weedy rice samples fell into two major clusters. Cluster I contained three weedy rice samples and four wild. In Cluster II, 377 weedy rice samples were closely related to the four cultivated rice cultivars as well as brownbeard rice (Oryza rufipogon Griffiths) wild species. The results suggest that weedy rice in northeast Thailand may have originated as a cross between cultivated and wild rice, as seen in the closely related species, O. rufipogon. Overall, the findings of this study demonstrate the high genetic diversity of weedy rice in this region. Notably, some samples adapted, performing more like cultivated rice, which may be problematic for the future production of high-quality rice in this region. The prevention of weedy rice should, therefore, be given greater consideration in future studies.
Detection of Long‐ and Short‐Term Slow Slip Events Using a Network Inversion Filter and Dense Global Navigation Satellite System Network in Shikoku, Japan
Authors: Ozawa Shinzaburo , Munekane Hiroshi , Suito Hisashi 
Published: October 2023

AbstractThe study of slow slip events is essential to elucidating the slip mechanisms and frictional properties of plate interfaces. We imaged the aseismic slip at the plate interface between the subducting Philippine Sea Plate and overriding Amur Plate beneath Shikoku Island, Japan, by applying a network inversion filter to the position time series obtained from Global Navigation Satellite System data spanning January 2012 to April 2022. The results show long‐term slow slip events in the Bungo Channel, central Shikoku, and the Kii Channel, which started from 2018. We also identified 39 short‐term slow slip events associated with low‐frequency tremors. The estimated moment magnitudes of the Bungo Channel, central Shikoku, and Kii Channel slow slip events were Mw7.0, Mw6.4, and Mw6.3, respectively, with a rigidity of 30 GPa. The estimated moment magnitudes of the short‐term slow slip events ranged from Mw5.7 to Mw6.4. Most of the detected short‐term slow slip events are associated with low‐frequency tremor, and many showed propagation through the spatial domain. Events with magnitudes of ≥Mw6.30 typically consist of subevents. The slip rate of short‐term slow slip events ranges from 1 to 7 mm/day, which is considerably larger than the plate convergence rate. The short‐term slow slip events are 6 to 40 days, and follow the accepted scaling law between slip event duration and total magnitude. The short‐term slow slip event zone is consistent with a three‐segment hypothesis. The short‐term slow slip event in northwest Shikoku and long‐term slow slip event in central Shikoku may be correlated.
Submersed Macrophyte Density Regulates Aquatic Greenhouse Gas Emissions
Authors: Theus Meredith E. , Ray Nicholas E. , Bansal Sheel , Holgerson Meredith A. 
Published: October 2023

AbstractShallow freshwater ecosystems emit large amounts of greenhouse gases (GHGs), such as carbon dioxide (CO2) and methane (CH4), yet emissions are highly variable. The role that aquatic macrophytes play in regulating aquatic GHG emissions is uncertain despite their ability to dominate shallow waterbodies. Here, we studied the effects of submersed macrophyte (Ceratophyllum demersum) density on CO2 and CH4 concentrations and fluxes. We conducted a 61‐days experiment using mesocosms containing one of the following C. demersum density treatments: 0, 10, 20, or 30 individual shoots (n = 3). We found that high density C. demersum had the highest CO2 and CH4 surface water concentrations and emissions while there was no significant difference in CH4 in the low and medium densities and no plant control. The high density treatment lost biomass over the course of the experiment, indicating die‐off and additions of organic matter to the sediment. High organic matter loading and low dissolved oxygen likely stimulated GHG production in the high density treatment. Our results emphasize that submersed macrophyte density and periods of growth and dieback are important in regulating GHG emissions, which may help explain why shallow waterbodies are high yet variable sources of GHGs to the atmosphere.
A Simple Eddy Potential Vorticity Flux Closure
Authors: Eden Carsten 
Published: October 2023

AbstractIt is shown that within the limits of quasi‐geostrophic scaling, biharmonic mixing of potential vorticity is equivalent to biharmonic lateral friction together with biharmonic isopycnal thickness mixing in primitive equations, all with the same viscosity. The problem of unbalanced zonal forces related to the planetary vorticity gradient disappears using a biharmonic instead of a harmonic closure. The former is appropriate for eddy‐permitting ocean models which are replacing now more and more the non‐eddy‐resolving model versions in coupled state‐of‐the‐art climate models. Numerical experiments demonstrate that including biharmonic thickness mixing has some benefits regarding stronger eddy production in marginally eddying ocean models, in particular when the grid size is larger than the baroclinic Rossby radius. Going to finer grids where relative vorticity dominates, however, using only biharmonic friction becomes similar to biharmonic mixing of potential vorticity, justifying the long‐standing use of biharmonic friction in reasonably well resolved eddy‐permitting ocean models.
The Role of Snowmelt Temporal Pattern in Flood Estimation for a Small Snow‐Dominated Basin in the Sierra Nevada
Authors: Yan Hongxiang , Sun Ning , Wigmosta Mark S. , Duan Zhuoran , Gutmann Ethan D. , Kruyt Bert , Arnold Jeffrey R. 
Published: October 2023

AbstractPrior research confirmed the substantial bias from using precipitation‐based intensity‐duration‐frequency curves (PREC‐IDF) in design flood estimates and proposed next‐generation IDF curves (NG‐IDF) that represent both rainfall and snow processes in runoff generation. This study improves the NG‐IDF technology for a snow‐dominated test basin in the Sierra Nevada. A well‐validated physics‐based hydrologic model, the Distributed Hydrology Soil Vegetation Model (DHSVM), is used to continuously simulate snowmelt and streamflow that are used as benchmark data sets to systematically assess the NG‐IDF technology. We find that, for the studied small snow‐dominated basin, the use of standard rainfall hyetographs in the NG‐IDF technology leads to substantial underestimation of design floods. Thus, we propose probabilistic hyetographs that can represent unique patterns of events with different underlying mechanisms. For the test basin where flooding events are generated entirely by snowmelt, we develop a hyetograph that characterizes snowmelt temporal patterns, which greatly improves the performance of NG‐IDF technology in design flood estimates. In contrast to the standard rainfall hyetographs characterized by a symmetrically peaked, bell‐shaped curve, the snowmelt hyetograph displays a more rapid rise (i.e., greater intensity) and a distinct diurnal pattern influenced by solar energy input. The results also show that the uncertainty of hyetography plays an important role in design flood estimation and can have important implications for future flood projections.
Evapotranspiration From Developed Land and Urban Watersheds in a Humid Subtropical Climate
Authors: Diem Jeremy E. , Carlton Dinah K. , Pangle Luke A. 
Published: October 2023

AbstractUrbanization introduces new and alters the existing hydrological processes. Projecting the direction and magnitude of change of evapotranspiration (ET), often a large existing process, in humid subtropical climates is difficult due to the lack of land‐cover specific estimates of ET. This research aims to improve our fundamental understanding of ET in urban areas by focusing on ET specific to land‐cover classes of the National Land Cover Database (NLCD). Using multiple physically based models along with ET from reference watersheds, this study estimates ET—within the Atlanta, GA, USA region—for NLCD classes. ET also is estimated for urban watersheds—both in the Atlanta region and in areas with humid subtropical climate types—for which published ET estimates exist. There are major differences in land cover among the four developed classes: high‐intensity developed land is 92% impervious surfaces, while open‐space developed land—the least intensively developed land—is only 8% impervious surfaces. Consequently, open‐space developed land has an ET total that is over four times that of high‐intensity developed land. Due to a high percentage of impervious cover and substantial evaporation of water from impervious surfaces throughout the year, there is little intra‐annual variation in ET for the high‐intensity developed class. The land‐cover ET totals aggregate to reliable estimates for urban watersheds. The largest source of uncertainty for ET estimates in urban areas is likely the evaporation magnitude associated with impervious surfaces; therefore, more work is needed in determining those magnitudes for humid subtropical climates.
Real-world effectiveness of an intranasal spray A8G6 antibody cocktail in the post-exposure prophylaxis of COVID-19
Authors: Li Xiaosong , Peng Pai , Deng Haijun , Yang Qian , Chen Shi , Li Benhua , He Miao , Jin Aishun , Yang Zhu , Tang Ni , Huang Ailong 
Published: October 2023

AbstractPreviously, we identified an antibody combination A8G6 that showed promising efficacy in COVID-19 animal models and favorable safety profile in preclinical models as well as in a first-in-human trial. To evaluate the real-word efficacy of A8G6 neutralizing antibody nasal spray in post-exposure prophylaxis of COVID-19, an open-label, non-randomized, two-arm, blank-controlled, investigator-initiated trial was conducted in Chongqing, China (the register number: ChiCTR2200066416). High-risk healthy participants (18–65 years) within 72 h after close contact to COVID-19 patients were recruited and received a three-dose (1.4 mg/dose) A8G6 treatment daily or no treatment (blank control) for 7 consecutive days. SARS-CoV-2 infection occurred in 151/340 (44.4%) subjects in the blank control group and 12/173 (6.9%) subjects in the A8G6 treatment group. The prevention efficacy of the A8G6 treatment within 72 h exposure was calculated to be 84.4% (95% CI: 74.4–90.4%). Moreover, compared to the blank-control group, the time from the SARS-CoV-2 negative to the positive COVID-19 conversion was significantly longer in the AG86 treatment group (mean time: 3.4 days vs 2.6 days, p = 0.019). In the secondary end-point analysis, the A8G6 nasal treatment had no effects on the viral load at baseline SARS-CoV-2 RT-PCR positivity and the time of the negative COVID-19 conversion. Finally, except for 5 participants (3.1%) with general adverse effects, we did not observe any severe adverse effects related to the A8G6 treatment. In this study, the intranasal spray AG86 antibody cocktail showed potent efficacy for prevention of SARS-CoV-2 infection in close contacts of COVID-19 patients.
Interrelations of resilience factors and their incremental impact for mental health: insights from network modeling using a prospective study across seven timepoints
Authors: Schäfer Sarah K. , Fritz Jessica , Sopp M. Roxanne , Kunzler Angela M. , von Boros Lisa , Tüscher Oliver , Göritz Anja S. , Lieb Klaus , Michael Tanja 
Published: October 2023

AbstractResilience can be viewed as trajectory of stable good mental health or the quick recovery of mental health during or after stressor exposure. Resilience factors (RFs) are psychological resources that buffer the potentially negative effects of stress on mental health. A problem of resilience research is the large number of conceptually overlapping RFs complicating their understanding. The current study sheds light on the interrelations of RFs in the face of the COVID-19 pandemic as a use case for major disruptions. The non-preregistered prospective study assessed a sample of 1275 German-speaking people from February 2020 to March 2021 at seven timepoints. We measured coping, hardiness, control beliefs, optimism, self-efficacy, sense of coherence (SOC), sense of mastery, social support and dispositional resilience as RFs in February 2020, and mental health (i.e., psychopathological symptoms, COVID-19-related rumination, stress-related growth) at all timepoints. Analyses used partial correlation network models and latent growth mixture modeling (LGMM). Pre-pandemic RFs were strongly interrelated, with SOC being the most central node. The strongest associations emerged between coping using emotional support and social support, SOC and sense of mastery, and dispositional resilience and self-efficacy. SOC and active coping were negatively linked. When we examined RFs as predictors of mental health trajectories, SOC was the strongest predictor of psychopathological symptoms and rumination, while trajectories of stress-related growth were predicted by optimism. Subsequent network analyses, including individual intercepts and slopes from LGMM, showed that RFs had small to moderate associations with intercepts but were unrelated to slopes. Our findings provide evidence for SOC playing an important role in mental distress and suggest further examining SOC’s incremental validity. However, our results also propose that RFs might be more important for stable levels of mental health than for adaptation processes over time. The differential associations for negative and positive outcomes support the use of multidimensional outcomes in resilience research.
NSG1 promotes glycolytic metabolism to enhance Esophageal squamous cell carcinoma EMT process by upregulating TGF-β
Authors: Tu Mingshu , Yin Xiaoqing , Zhuang Wanzhen , Lin Xiaoqing , Xia Yu , Huang Zhixin , Zheng Yue , Huang Yi 
Published: October 2023

AbstractAs a highly enriched endosomal protein within neuronal cells, NSG1 has been discovered to facilitate the process of epithelial-mesenchymal transition (EMT) in esophageal squamous cell carcinoma (ESCC). However, the precise mechanisms behind this phenomenon have yet to be elucidated. The pivotal role of transforming growth factor-β (TGF-β) in triggering the EMT and its significant contribution towards tumor metabolic reprogramming—responsible for EMT activation—has been robustly established. Nevertheless, the extent of TGF-β involvement in the NSG1-mediated EMT within ESCC and the processes through which metabolic reprogramming participates remain ambiguous. We accessed an array of extensive public genome databases to analyze NSG1 expression in ESCC. Regulation of TGF-β by NSG1 was analyzed by transcriptome sequencing, quantitative Real-Time PCR (qRT-PCR), co-immunoprecipitation (CO-IP), and immunofluorescence (IF). Additionally, cellular functional assays and western blot analyses were conducted to elucidate the effect of NSG1 on TGF-β/Smad signaling pathway, as well as its role in ESCC cell metastasis and proliferation. We validated the influence of the NSG1/TGF-β axis on metabolic reprogramming in ESCC by measuring extracellular acidification, glucose uptake, and lactate production. Our findings identify an oncogenic role for NSG1 in ESCC and show a correlation between high NSG1 expression and poor prognosis in ESCC patients. Additional research indicated TGF-β’s involvement in the NSG1-induced EMT process. From a mechanistic perspective, NSG1 upregulates TGF-β, activating the TGF-β/Smad signaling pathway and subsequently fostering the EMT process by inducing cell metabolic reprogramming—evident from elevated glycolysis levels. In conclusion, our study highlights the NSG1/TGF-β axis as a promising therapeutic target for ESCC.
Does e-cigarette use affect response to non-surgical periodontal therapy?
Authors: Kumar Satish , Shlossman Marc 
Published: October 2023

Abstract
Design
Cross-sectional study

Case selection
Consecutive patient charts (n = 220) at Guy’s Dental Hospital between April 2018 and April 2020 were included. The inclusion criteria were adults ≥18 years with a diagnosis of periodontitis (localized or generalized, all stages and grades) and who have received professional mechanical plaque removal (PMPR) by periodontology graduate students. Data of periodontal indices before and after PMPR (6–20 weeks) were also needed to be available. Exclusion criteria included uncontrolled diabetes, pregnancy, medications attributed to drug induced overgrowth, among others.

Data analysis
This retrospective study evaluated the response to periodontal treatment in e-cigarette users and they compared the outcomes to non-smokers, former and current smokers. The primary outcome to evaluate the response to periodontal therapy was ‘need for surgery’. This was defined by the authors as the number of sextants with ≥2 non-adjacent sites with probing depth (PD) ≥ 5 mm after PMPR. Secondary outcomes included periodontal parameters such as number of sextants with ≥1 site with PD ≥ 5 mm, PD, clinical attachment level (CAL), bleeding on probing, recession, and plaque scores.

Results
E-cigarette users and current smokers had similar poorer clinical response to periodontal therapy. Analysis revealed e-cigarette users had more sextants with ‘need for surgery’ as the primary outcome. Pocket closure outcome (PD ≤ 4 mm with no bleeding on probing) were highest in nonsmokers (77.1%), followed by former smokers (74.9%), current smokers (69.4%), and e-cigarette users (66.6%).

Conclusions
E-cigarette users showed less than beneficial response to periodontal therapy compared to non-smokers, who had the best outcome overall.