bluuebunny/crossref_metadata_2025_split huggingface dataset:
Gesetzliche Vorgaben zur Aufklärung und deren Einfluss auf die
Patientenzufriedenheit
Authors: Briegel Wolfgang , Lopez de Miguel Pilar 
Published: January 2025

ZusammenfassungDas Patientenrechtegesetz definiert unter anderem ärztliche Pflichten im
Zusammenhang mit der Aufklärung. Bis dato wurde in Deutschland nicht
untersucht, inwiefern diese gesetzlichen Vorgaben auch die Zufriedenheit mit
der Aufklärung beeinflussen, Dieser unter dem Gesichtspunkt des
Qualitätsmanagements wichtigen Frage widmet sich diese Studie.Anonymisierte Patientenbefragung zur Zufriedenheit mit der Aufklärung, die
mittels eines validierten 10 Item-Fragebogens erfasst wurde.189 Aufklärungsgespräche (n=105 weibliche, n=84 männliche Patienten) gingen
in die Auswertung ein. 87,8% (n=166) der Patienten befanden sich in
stationärer Behandlung, 12,2% (n=23) wurden ambulant behandelt. Die
Patienten waren im Mittel 53,2 Jahre alt (Standardabweichung: 20,3 Jahre,
Spannbreite: 15 bis 97 Jahre) und verteilten sich über folgende
Behandlungsbereiche: Anästhesie: n=68; Chirurgie: n=60; Innere Medizin:
n=56; Kinder- und Jugendpsychiatrie, Psychosomatik und Psychotherapie: n=5
Patienten. Es ergab sich insgesamt eine hohe Zufriedenheit mit der
Aufklärung, die sich zwischen den Geschlechtern nicht signifikant
unterschied. Allerdings waren Patienten zufriedener, wenn sie von Ärzten mit
Deutsch als Muttersprache (p=0,005; d=0,214) bzw. von Fachärzten
(p<0,001; d=0,288) aufgeklärt wurden. Die Dauer des Aufklärungsgesprächs
korrelierte signifikant positiv mit der Zufriedenheit (p=0,002, r=0,211). Es
konnte außerdem gezeigt werden, dass dem Weiterbildungsstand des Arztes
(Facharzt: Ja/Nein) die größte Bedeutung zukommt (adjusted Odds Ratio:
4,48).Die Vorgaben des Patientenrechtegesetzes bzgl. Verständlichkeit und
Ausführlichkeit der Aufklärung sowie Kompetenz des aufklärenden Arztes
tragen nachweislich zur Patientenzufriedenheit bei. Daher ist immer auf eine
ausreichende fachliche Kompetenz zu achten. Bei aufklärenden Ärzten, deren
Muttersprache nicht Deutsch ist, sollte der Einsatz von
Übersetzungsprogrammen, Informationen in bildlicher Form oder von
(zusätzlichen) Video-Aufklärungen erwogen werden, um eine etwaige
Sprachbarriere zu minimieren. Darüber hinaus sollte für eine möglichst hohe
Zufriedenheit die Dauer des Aufklärungsgespräches möglichst gut an die
individuellen Patientenbedürfnisse angepasst werden. Dazu empfiehlt es sich,
die Patienten vorab zu fragen, wie ausführlich sie sich die Aufklärung
wünschen.
Cortical Neurotransmitters Measured by Magnetic Resonance Spectroscopy Change Following Traumatic Brachial Plexus Injury
Authors: Wade Ryckie G. , Bourke Gráinne , Olaru Alexandra M. , Williams Stephen R. , Shelley David , Plein Sven , Bains Robert D. , Bedford James D. , Newton Lucy E. Homer , Ng Chye Yew , Parkes Laura , Lea-Carnall Caroline 
Published: January 2025

Abstract
Introduction GABA (γ-aminobutyric acid) is the major inhibitory neurotransmitter in the brain. In response to injury within the central nervous system, GABA promotes cortical plasticity and represents a potential pharmacological target to improve functional recovery. However, it is unclear how GABA changes in the brain after traumatic brachial plexus injuries (tBPIs) which represents the rationale for this pilot study.
Methods We serially scanned seven males (mean age 42 years [SD 19] without head injury) up to 19 months after tBPIs. T1-weighted images (1-mm isotropic resolution) and J-edited spectra (MEscher–GArwood Point RESolved Spectroscopy [MEGA-PRESS], TE 68 ms, TR 2,000 ms, 2 cm isotropic voxels) were acquired using a MAGNETOM Prisma 3T (Siemens Healthcare, Erlangen, Germany). Data were analyzed in jMRUI blind to clinical information to quantify GABA, creatine plus phosphocreatine (Cr), and N-acetylaspartate (NAA) concentrations. Additionally, gray matter and white matter proportions were assessed using SPECTRIM software. Interhemispheric means were compared using linear methods. Confidence intervals (CIs) were generated to the 95% level.
Results Within weeks of injury, the hemisphere representing the injured upper limb had a significantly lower GABA:NAA ratio (mean difference 0.23 [CI 0.06–0.40]) and GABA:Cr ratio (mean difference 0.75 [CI 0.24–1.25]) than the uninjured side. There were no interhemispheric differences in NAA:Cr. By 12 months post-injury, interhemispheric differences in metabolite concentrations equalized. There was no difference in the proportion of gray matter, white matter, or cerebrospinal fluid between the injured and uninjured hemispheres.
Conclusion After brachial plexus injuries, there are interhemispheric differences in GABA concentrations within the sensory and motor cortex. This represents a potential pharmacological target that warrants further investigation.
Geschlechtsspezifische Unterschiede in uro-onkologischen Studien
Authors: Roesch Marie Christine , Lütje Lea Sophie , Gilbert Nils , Merseburger Axel Stuart , Osmonov Daniar 
Published: January 2025

ZusammenfassungObwohl Subgruppenanalysen in klinischen Studien teilweise geschlechtsspezifische Unterschiede in den Ergebnissen aufweisen, gibt es nur selten eine Zulassungsbeschränkung auf nur ein Geschlecht oder geschlechtsangepasste Dosierungsempfehlungen. Außerdem sind Differenzen in den geschlechtsspezifischen Studieneinschlussraten im Vergleich zu den jeweiligen Inzidenz- oder Prävalenzraten wahrzunehmen. Der folgende Artikel beleuchtet geschlechtsspezifische Unterschiede in uro-onkologischen klinischen Studien.
The Characteristics and Functions of Orally Absorbed Herbal Decoction-Borne Plant MicroRNAs
Authors: Zhu Yating , Yu Yicheng , Jia Yao , Lin Ziqi , Lei Jinyue , Wu Diyao , Xu Tielong , Li Longxue , Zheng Bin 
Published: January 2025

AbstractHerbal decoctions always contain numerous plant microRNAs, and some of these can be absorbed orally to exert cross-kingdom gene regulation. However, little is known about which specific types of herbal decoction-borne plant microRNAs are more likely to be absorbed. Thus, two antiviral herbal decoctions, Qingfei Paidu and Qingre Huashi Kangdu, were administered to human volunteers and rats, respectively, to investigate the characteristics of orally absorbed decoction-borne plant microRNAs. MIR-6240 – 3 p was identified as an absorbed plant microRNA in humans and is most highly expressed in Qingfei Paidu decoction. Therefore, the kinetics of MIR-6240 – 3 p were monitored in humans following the administration of the Qingfei Paidu decoction, and its antiviral effect on human coronavirus type 229E (HCoV-229E) was examined in vitro. There were 586 176 small RNAs identified in Qingfei Paidu decoction, of which 100 276 were orally absorbed by humans. In the Qingre Huashi
Kangdu decoction, 124 026 small RNAs were detected, with 7484 being orally absorbed by rats. Logistical repression analysis revealed that absorbable plant small RNAs in both humans and rats presented higher expression levels, greater minimum free energy, and increased AU/UA frequencies compared to nonabsorbable plant small RNAs. The amount of MIR-6240 – 3 p in humans increased between 1 and 3 h after the administration of the Qingfei Paidu decoction. In addition, MIR-6240 – 3 p significantly reduced the RNA copy number and TCID50 of HCoV-229E in vitro. These results suggest that herbal decoction-borne plant small RNAs with a higher expression level, greater minimum free energy, or an increased AU/UA frequency are more likely to be orally absorbed and could potentially mediate cross-kingdom gene regulation.
Unexpected Side Products in the Large-Scale Preparation of 2,3-Dihydro-1,1,2,2,3,3-hexamethyl-1H-indene
Authors: Raev Vitaly , de Meijere Armin , Hopf Henning , Jones Peter G. 
Published: January 2025

AbstractDuring the development of an optimized procedure for the synthesis of 2,3-dihydro-1,1,2,2,3,3-hexamethyl-1H-indene significant amounts of 5-tert-butyl-2,3-dihydro-1,1,2,2,3,3-hexamethyl-1H-indene were formed, along with 5-tert-hexyl-2,3-dihydro-1,1,2,2,3,3-hexamethyl-1H-indene under certain conditions. The structures of 5-tert-hexyl-2,3-dihydro-1,1,2,2,3,3-hexamethyl-1H-indene and 5-tert-butyl-2,3-dihydro-1,1,2,2,3,3-hexamethyl-1H-indene were established by spectroscopic means and confirmed by X-ray single-crystal structure determinations. The mechanism for the formation of 5-tert-butyl-2,3-dihydro-1,1,2,2,3,3-hexamethyl-1H-indene is discussed.
Study on Self-Monitoring Method of Ankle Impedance
Authors: Huang Yijun , Luo Ruian , Xu Chen , Cheng Weigen , Su Hai , Xia Linglin 
Published: January 2025

Abstract
Objective The aim of the study was to analyze the self-monitoring ankle impedance measuring instrument for patients with heart failure and to evaluate the degree of ankle impedance variation in normal young people for three days.
Methods We developed a portable impedance measuring instrument based on AD5940 chip of ADI. The circuit composed of programmable alternating current (AC) voltage generator, digital signal processor, microcontroller, and related peripheral circuits. The four-line body impedance analysis measurement method was used, which was powered by two 1.5-V batteries, and a frequency of 50 kHz was selected to improve the measurement accuracy. The bioimpedance of the human body can be measured in the range of 0 to 2,000 Ω, and the phase range is –180 to + 180 degrees, both of which are accurate to two decimal places. Ten normal young volunteers were included, with an average age of 24.5 ± 1.3 years. The electrical impedance of the right ankle was measured in the sitting position, the supine position, and the standing position. Each posture was measured three times, and the variation of the ankle impedance was observed for three days at the same time point.
Results There was no significant difference in ankle impedance between the three positions of 10 volunteers in this group during the three days. The mean difference between the mean groups ranged from 6.14 to 9.53%, and the maximum difference was 9.53%. There was no significant correlation between ankle impedance and BMI in the three positions.
Conclusion Although there are some changes in the ankle impedance measured by the self-developed impedance tester within three days, it can still monitor the ankle impedance of normal young people relatively stably. This impedance meter may be used for home monitoring of ankle impedance in patients with heart failure.
Validity and reliability of the Turkish version of the Innsbruck RBD-9 diagnostic inventory (IRBD-9-TR)
Authors: Aslan-Kara Kezban , Ak Ayşın Kısabay , Sarıtaş Ayşegül Şeyma , Yılmaz Hikmet , Metin Kübra Mehel , Çokal Burcu Gökçe , Ağan Kadriye , Aksu Murat , Akyıldız Utku Oğan , Demir Aylin Bican , Çevik Betül , Ertürk Ahmet Yusuf , Karadeniz Derya , Öztura İbrahim , Sünter Gülin , Tekin Selma , Tezer İrsel , Berktaş Deniz Tuncel , Totik Nazlı , Şenel Gülçin Benbir 
Published: January 2025

Abstract
Background Isolated rapid eye movement (REM) sleep behavior disorder (iRBD) is characterized by loss of the normal atonia of REM sleep accompanied by repetitive motor and behavior phenomena of dream content.
Objective To evaluate the reliability and validity of the Turkish version of the original form of the Innsbruck Rapid Eye Movement Sleep Behavior Disorder Diagnostic Inventory (IRBD-9) scale (IRBD-9-TR) and ensure that this screening test can be easily used in the Turkish language.
Methods The present is a multicenter and prospective study involving 184 patients: 51 with iRBD and 133 healthy controls. The iRBD patients were not diagnosed before submitted to video polysomnography (vPSG) and filling out the IRBD-9-TR.
Results The optimal cut-off value for the IRBD-9-TR symptom score was of 0.28, with a sensitivity of 0.941 and a specificity of 0.947, and 94.4% of the patients were correctly diagnosed. The rotated factor loadings for the diagnostic accuracy of each individual question showed that the short version of the IRBD-9-TR (questions 1, 2, 3, 6, and 8) presented higher specificity and excellent discrimination of iRBD patients from healthy controls. The Cronbach's α coefficient for the symptom section of the IRBD-9-TR was of 0.857, and the Kappa coefficient, of 0.885.
Conclusion The short version of the IRBD-9-TR presents good validity and reliability to be used as a screening test to assess iRBD patients. It is convenient and potentially useful in both outpatient clinical and epidemiologic research settings.
Percutaneous Transgastric Endoscopic Interventions
Authors: Jain Neil K. , Mir Aazrin , Nezami Nariman , Smirniotopoulos John B. 
Published: January 2025

AbstractGastrointestinal and hepatobiliary diseases are managed by various specialists, including gastroenterologists, surgeons, and interventional radiologists. Percutaneous cholangioscopy and endoscopy have immense potential within the field of interventional radiology (IR), especially given the unique ability to combine fluoroscopic guidance with direct visualization of internal structures. Transgastric endoscopy, in particular, is valuable for patients who already have established gastrostomy access or those unsuitable for surgery or traditional esophagogastroduodenoscopy. Cases of transgastric endoscopy have shown successful treatments for choledocolithiasis, duodenal collections, pancreatic leaks, and foreign body removal. As more research is conducted, percutaneous endoscopy could become an integrated part of various IR procedures, providing personalized treatment for patients who have exhausted conventional approaches.
Tradução e validação de conteúdo do Plastic Surgery Milestones Project 2.0 para a língua portuguesa
Authors: Verona Dunia , Ilgenfritz Antonio Pacheco , Souza Juliano Mendes de , Collares Carlos Fernando , Sakaki Daniel Yukio , Mennin Stewart , Pauli Beatriz Lanza 
Published: January 2025

Resumo
Introdução A avaliação das competências adquiridas durante a residência médica em cirurgia plástica permanece desafiante. O objetivo deste estudo foi validar o instrumento The Plastic Surgery Milestones Project 2.0, ferramenta utilizada para avaliar as competências desenvolvidas pelos médicos residentes em cirurgia plástica dos programas credenciados no Conselho de Acreditação de Cursos de Graduação em Educação Médica (Accreditation Council for Graduate Medical Education, ACGME, em inglês) dos Estados Unidos, para possibilitar o uso nos programas de residência médica em cirurgia plástica no Brasil.
Materiais e Métodos O processo envolveu autorização do ACGME, tradução do instrumento para o português, adaptação por especialistas em Cirurgia Plástica, validação do conteúdo com base em referencial teórico e retrotradução para avaliar a equivalência semântica.
Resultados Os resultados indicaram que o instrumento adaptado se manteve semelhante ao original após considerações e ajustes realizados pelos especialistas brasileiros. Com a retrotradução, avaliada tanto por um especialista em educação médica quanto pelo ACGME, precursor do instrumento, atestou-se a adequação da tradução, o que permitiu a validação do conteúdo do instrumento para o contexto da cirurgia plástica no Brasil. A semelhança entre as competências brasileiras e internacionais possibilitou essa adaptação bem-sucedida.
Conclusão A tradução e adaptação do instrumento Milestones para a cultura brasileira foi bem-sucedida, e manteve as propriedades psicométricas do original, com a versão adaptada pronta para aplicação, embora estudos adicionais sejam necessários para validar sua acurácia e confiabilidade nos programas brasileiros.
Comparative Radiological Outcomes of Stand-alone Cage versus Cage and Plate in Anterior Cervical Discectomy and Fusion: A Retrospective Cohort Study
Authors: Moghamis Isam Sami , Alhammoud Abduljabbar , Elshoeibi Amgad M. , Abudalou Abedallah , Derbas Jawad , Alhardallo Mutaz Awad , Abdelsalam Salahuddeen , Baco Abdulmoeen 
Published: January 2025

Abstract
Background Anterior cervical discectomy and fusion (ACDF) is one of the most commonly used techniques for neural decompression in degenerative cervical radiculopathy and cervical myelopathy. Controversies regarding the superiority of cage augmentation with anterior cervical plate remain, yet several surgeons are still performing ACDF with a stand-alone cage (ACDF-SA). Our study aimed to compare the radiological outcomes between the ACDF augmented with anterior cervical plate (ACDF-CPA) and ACDF-SA in single-level cervical degenerative disc disease.
Methods A retrospective data review was conducted for patients who underwent ACDF between January 2011 and December 2019. All adult patients who underwent single-level ACDF for cervical radiculopathy and myelopathy with at least 12 months of follow-up were included in the study. Patients who had a systemic infection, trauma injury, history of malignancy, inadequate radiographs, and less than 12 months of follow-up were excluded from the study. Radiological outcomes, including cage subsidence, fusion rate, and adjacent segment degeneration, were assessed by two senior orthopaedic spine fellows. Adjusted risk ratios were used to compare the radiological outcomes of ACDF-SA and ACDF-CPA, adjusting for age and gender.
Results A total of 43 patients were included. Among them, 58% of the patients underwent a stand-alone cage ACDF, while 42% had anterior cervical plate augmentation. The overall fusion rate at 6 months was 76%. The ACDF-SA group's fusion rate was 88%, while that of the ACDF-CPA group was 61%. At 12 months, the overall fusion rate was 81% and was comparable between the two groups. Cage subsidence and adjacent segment degeneration rates were similar between the groups at 6 and 12 months. Adjusted relative risk analysis showed a 50% higher probability of fusion at 6 months in the ACDF-SA group compared with the ACDF-CPA group (95% confidence interval [CI]: 1.01–2.22) and a 22% higher probability at 12 months, though not statistically significant (95% CI: 0.90–1.64). Female gender was associated with higher fusion rates and lower subsidence risk at 12 months.
Conclusion Augmentation with the anterior cervical plate in ACDF did not show superiority to the conventional stand-alone cage in mono-segmental ACDF. Our study showed similar outcomes regarding cage subsidence, adjacent segment disease, and fusion rates at 12 months. However, the stand-alone cage achieved faster fusion at 6 months than the plate group.
An Innovative Technique of Reconstructing Combined Extensor Tendon Zone (z5 and z4) Defect, Utilizing an Adjacent Proximal (z6) Tendon, as a Distally Based Tendon Flip Flap, in the Index Finger
Authors: Mashalkar Narendra S. , Shiva Pooja Thoppal , Kattady Joseph 
Published: January 2025

AbstractDelayed reconstruction of segmental extensor tendon defects of the hand has been described with auto-tendon grafting or by using local flaps harvested from the native tendon. These reconstructive techniques have been described in certain extensor tendon zones, mainly in zones 2, 4, and 5 of the hand. Borrowing auto-tendon grafts will have donor site morbidity. The use of available local tendon as flap may be considered, the tendon harvesting being done from a part of the native tendon from either proximal or distal location. The index and little fingers have the advantage of having two tendons to do the same function and hence these tendons may be utilized as a whole to our advantage as distally based tendon flip flap to reconstruct zone 4 and 5 extensor tendon defects with good functional outcomes.
Unveiling Portal Vein Anatomy: Clinical Impact and Significance of Variants in Transjugular Intrahepatic Portosystemic Shunt Creation
Authors: Yancey Kristina , Ruddy Liane , Simmons Curtis L. , Crawford Daniel A. , Alzubaidi Sadeer , Naidu Sailen , Ozen Merve 
Published: January 2025

AbstractAn in-depth understanding of portal venous anatomy, particularly its variants, is essential for interventional radiologists performing complex hepatobiliary procedures such as transjugular intrahepatic portosystemic shunt (TIPS) creation. Anatomical variations in the portal venous system occur in approximately 35% of the population, and failure to identify these variants can result in significant procedural complications including vascular injury and postprocedural liver failure. This article discusses the most common (types I–V) portal vein variants and the importance of their preprocedural identification, their potential impact on procedural outcomes, and the role of advanced imaging techniques in mitigating risks associated with these anatomical variations.
Time-resolved vibronic spectra with nuclear–electronic orbital time-dependent configuration interaction
Authors: Garner Scott M. , Upadhyay Shiv , Li Xiaosong , Hammes-Schiffer Sharon 
Published: January 2025

Time-resolved spectroscopy is an important tool for probing photochemically induced nonequilibrium dynamics and energy transfer. Herein, a method is developed for the ab initio simulation of vibronic spectra and dynamical processes. This framework utilizes the recently developed nuclear–electronic orbital time-dependent configuration interaction (NEO-TDCI) approach, which treats all electrons and specified nuclei quantum mechanically on the same footing. A strategy is presented for calculating time-resolved vibrational and electronic absorption spectra from any initial condition. Although this strategy is general for any TDCI implementation, utilizing the NEO framework allows for the explicit inclusion of quantized nuclei, as illustrated through the calculation of vibrationally hot spectra. Time-resolved spectra produced by either vibrational or electronic Rabi oscillations capture ground-state absorption, stimulated emission, and excited-state absorption between vibronic states. This methodology provides the foundation for fully ab initio simulations of multidimensional spectroscopic experiments.
Why the universal threshold for primordial black hole formation is universal
Authors: Kehagias Alex , Perrone Davide , Riotto Antonio 
Published: January 2025

Abstract
We show why the threshold for primordial black hole formation is universal (independent from the shape of the perturbation) when expressed in terms of the volume averaged compaction function. The proof is rooted in the self-similarity of the gravitational collapse phenomenon at criticality.
Planck’s constant from Stefan’s radiation law: a study of gray radiations of tungsten filament bulb
Authors: Rawal Ishpal 
Published: January 2025

Abstract
This study introduces a straightforward approach to determine Planck’s constant in an undergraduate course at the college or university level through the analyses the current–voltage (I–V) characteristic of a tungsten filament bulb. Unlike conventional methods, this analysis does not require the use of a color filter or an additional photodiode to select a specific wavelength or measure the emitted energy density from the filament. The temperature of the filament was computed by measuring the resistance of the filament. The obtained temperature and the input power of the filament are then used to estimate the emissivity of the filaments using Stefan–Boltzmann’s law, which is found to be lower than that of a perfect black body, i.e. unity. Therefore, the radiation emitted from the tungsten filament can be classified as gray radiation. The maximum energy density (intensity) of the emitted radiation is determined by calculating the consumed power of the filament. Finally, the obtained values of temperature, Stefan’s constant, and the intensity of the emitted radiations are used to calculate Planck’s constant. The calculated value of Planck’s constant is found to be 6.102 × 10−34 Js, which closely matches the standard value of Planck’s constant (6.626 × 10−34 Js). This close correlation between the two values validates the effectiveness of the present method.