bluuebunny/crossref_metadata_2025_split huggingface dataset:
CONSIDERACIONES FARMACOLÓGICAS Y DE PROPIEDAD INTELECTUAL PARA EL DESARROLLO DE MEDICAMENTOS USADOS EN EL TRATAMIENTO DE COVID-19
Authors: Soto Vázquez Dr. Ramón 
Published: November 2023

La infección por SARS-CoV-2 ha generado graves problemas de salud a la humanidad, por tratarse de una enfermedad infecciosa causada por un agente etiológico nuevo, por lo que aún no se tiene un tratamiento específico. Gracias a los esfuerzos en conjunto de toda la sociedad científica se ha logrado identificar el virus, su estructura genómica y el cómo se desarrolla la infección de la COVID-19 en los pacientes diagnosticados. Debido a la continua investigación, la industria farmacéutica ofrece moléculas cuya actividad farmacológica es parcialmente positiva no solo para el tratamiento de los principales síntomas en diferentes etapas de la infección de COVID-19, sino también para las complicaciones que suelen presentarse en los pacientes si es que se actúa de manera temprana. En este artículo se realiza una revisión de las moléculas más usadas para el tratamiento de COVID-19 con la finalidad de proporcionar una guía sobre la factibilidad de uso de las moléculas conocidas que se usan en dicha enfermedad, para ello se realizó la recopilación bibliográfica de la información disponible hasta ahora sobre lo que se conoce de COVID-19 y de los principios activos que actúan efectivamente. Se hace especial énfasis en las propiedades fisicoquímicas y la estructura de los principios activos para dar las pautas de posibles tratamientos en la infección por COVID-19; además, se incluye una revisión de opinión sobre las patentes relacionadas a los mencionados principios activos para resaltar la facilidad de su posible uso o modificación de sus formulaciones
ESTUDIO DESCRIPTIVO (2012 – 2018) DEL PROCESO DE INVESTIGACIÓN EDUCATIVA Y PRODUCCIÓN DE CONOCIMIENTOS EN LA PRÁCTICA EDUCATIVA COMUNITARIA EN LA ESFM “MARISCAL SUCRE”
Authors: La Fuente Mari Marcela Magne 
Published: November 2023

Se expone la investigación cuyo objetivo es enunciar la lógica del proceso de investigación educativa y producción de conocimientos en la práctica educativa comunitaria efectivizada en la ESFM “Mariscal Sucre” que posibilite la identificación de las principales causas que provocan el problema central en dicho proceso.
Para la realización de la investigación se acudió a diferentes fuentes bibliográficas, documentales y a la aplicación de técnicas e instrumentos de indagación de campo.
Se concluye que las características principales de la lógica del proceso de Investigación Educativa y Producción de Conocimientos en la Práctica Educativa Comunitaria (IEPC-PEC) efectivizada en la ESFM “Mariscal Sucre” son: la gradualidad y sistematicidad establecidas en el proceso, el trabajo en equipos, el constituirse en eje de integración de las Unidades de Formación (asignaturas) y asumir la sistematización de experiencias educativas como modalidad de graduación.
Con relación a la última característica señalada, la institución formadora de maestros requiere impeler acciones de trabajo estructuradas que coadyuven en la orientación y seguimiento de procesos de sistematización de experiencias educativas de manera reflexiva y crítica en las que los futuros profesionales asuman su rol protagónico como sujetos empoderados en su formación desde la reivindicación de sus vivencias aprendidas.
PROMISING AREAS OF SCIENTIFIC RESEARCH ON THE PROBLEMS OF INTESTINAL INFECTIONS
Authors: Гончар Н.В. , Скрипченко Н.В. 
Published: November 2023

Решение современных проблем диагностики и лечения кишечных инфекций у детей определяет важнейшие направления научных исследований, в ряду которых стоят молекулярно- генетические и клинические особенности возбудителей вирусных диарей, совершенствование методов терапии острых гастроэнтеритов вирусной этиологии, молекулярная диагностика токсинпродуцирующих бактериальных кишечных патогенов, биологическая безопасность и кишечные инфекции, прогнозирование антибиотик-ассоциированной диареи и подходы к лечению, клиническое значение диареи условно- патогенной бактериальной этиологии у детей, антибиотикорезистентность энтеробактерий и эффективность фаготерапии, персонифицированная симбионтная терапия реконвалесцентов кишечных инфекций.
The solution of modern problems of diagnosis and treatment of intestinal infections in children is determined by the most important areas of scientifi c research, among which are the molecular genetics and clinical features of viral diarrhea pathogens, improvement of therapy methods for acute gastroenteritis of viral etiology, molecular diagnostics of toxin- producing bacterial intestinal pathogens, biological safety and intestinal infections, prediction of antibiotic- associated diarrhea and treatment approaches, clinical signifi cance of diarrhea of conditionally pathogenic bacterial etiology in children, antibiotic resistance of Enterobacteriaceae and the eff ectiveness of phage therapy, personalized symbiont therapy of convalescents of intestinal infections.
Trazos indóciles
Authors: La Rocca Paula 
Published: November 2023

El presente artículo busca describir el gesto singular de dos artistas contemporáneos que trabajan el problema de la copia y la falsificación. Por un lado, el conjunto de ejercicios caligráficos titulado Trabajos prácticos (2021) de Leticia Obeid, montado en el Museo Nacional del Grabado para la muestra “Transformaciones. La Gráfica en desborde” (2021). Por otro, la propuesta de Fabio Kacero titulada Firmas (2016) exhibida en la galería porteña Ruth Benzacar como “El campeón de los fantasmas”, donde el artista recoge casi doscientas firmas personales. Esta lectura sugiere como hipótesis que el lazo que funcionaba para certificar la autenticidad de una obra original ha sido despojado de su valor legal (que actualmente recae sobre otra cantidad de herramientas jurídicas), y en consecuencia, el lugar de la firma en artes ha sido desplazado. En efecto, en estas propuestas, el ejercicio de repetición responde a la necesidad de hallar la función actual de esos trazos para el campo de las artes. En ese sentido, la hipótesis indica que la copia, la reproducción, o incluso, la invención del dibujo de una firma se enlaza en la producción de una autoría, a la cual nos referiremos en los términos de Reinaldo Laddaga (2010) como “formas de autoría compleja”. Con ello, la acción plástica y visual de los trabajos citados se aleja de una posición enunciativa individualizante, para conectar, en cambio, una red o laboratorio colectivo de procesos.
Diversification Strategies of Indonesian Seaweed Commodities to Strengthen Markets, Competitiveness, and Economic Resilience of Coastal Communities
Authors: Tabrani Tabrani , Angkasa Wisman Indra , Rahmatika Dien Noviany , Firmansyah Fahmi , Rahajo Teguh Budi 
Published: November 2023

Background: This paper aims to study the potential, opportunities, problems, and strategies for diversifying seaweed commodities to strengthen markets, competitiveness, and economic resilience of coastal communities. Seaweed is an aquaculture product that can improve the people’s economic welfare, deploy many laborers, and even increase the country's foreign exchange.
Aim: The potential for seaweed distribution in Indonesia is wide open for those naturally grown and cultivated in the sea.
Method: There are good opportunities for the seaweed industry related to the potential for cultivation land, availability of raw materials, and demands for processed products. However, there are problems and challenges to the nation’s ability to export and compete for world market share to meet the world's seaweed needs.
Findings: They include low quality and continuity of raw materials, provided capital, weak human and institutional resources, and seaweed products marketing strategies. There must be appropriate strategies for the diversification of Indonesian seaweed commodities for market strengthening, competitiveness, and economic resilience of coastal communities
Effect of Production Strategy Performance on Brand Royalty
Authors: Endrianto Endrixs , Zaelani Adnan Ahmad , Asmiah Ninin , Nurmeliani Lia 
Published: November 2023

Background: Product strategy is a plan that identifies the goals and objectives of a product and then explains the vision to achieve those goals. This helps to relate the vision of the project with the actual methods used to implement it. Product strategy maps out key benchmarks for creating, marketing, and distributing any concept you plan to sell.
Aim: The purpose of this study is to determine the effect of production strategy performance on brand royalty in companies and restaurants.
Method: The sample used in this study can be determined using the infinite sample formula, with a 95% confidence level and a 10% error level, the sample used in this study was 100 people as respondents. The sampling technique in this study is non probability sampling with the Purposive Sampling.
Findings: They also provide a central plan that people across the business can refer to to guide their efforts and fine-tune their overall business strategy. Business in the food sector is a potential business at this time. Factors that need to be considered in facing competition in the restaurant business include products and prices. If these two factors are getting better and more attractive, it can make customers feel satisfied, if customers feel satisfied, they will be loyal to the restaurant
Dødskultur og sorgkultur
Authors: Hviid Jacobsen Michael , Petersen Anders 
Published: November 2023

Ifølge mange fremtrædende sociologer – herunder Anthony Giddens, Ulrich Beck, Zygmunt Bauman og Andreas Reckwitz blot for at nævne nogle få – lever vi i individualiseringens tidsalder. Det betyder, at det, der førhen var noget socialt og kollektivt, i stigende grad opfattes og opleves som noget individuelt. Dette gælder for stort set for alle forhold i livet. Det gælder imidlertid også for døden og sorgen.
Der er dog ingen tvivl om, at både død og sorg er kulturelle og kollektive fænomener, der formes af den historie, som knytter mennesker sammen i samfund og fællesskaber. Det er derfor, at det giver mening at tale om tilstedeværelsen af døds- og sorgkulturer, der forandrer sig over tid.
I dette kapitel vil vi kaste lys over død og sorg som kulturelle fænomener og gennem både teoretiske og empiriske nedslag demonstrere og illustrere, hvorledes død og sorg selv under påvirkninger fra individualiseringstendenser vedbliver med at være formet af og udtryk for kulturelle og kollektive forhold. Vi skal i den forbindelse bl.a. se på kulturbegrebet som et baggrundstæppe for at forstå menneskers forhold til død og sorg, og vi skal se nærmere på nogle overordnede historiske og kulturelle forandringer i døds- og sorgkultur, herunder tabuiseringen, privatiseringen og tilbagekomsten af døden over det seneste århundrede samt individualiseringen, professionaliseringen og stigmatiseringen af sorgen i samme periode. Formålet er således at vise, hvordan vores forhold til død og sorg hele tiden afspejler grundlæggende forandringer i den måde, som vi lever og forstår livet på.
Når kroppen har mistet
Authors: Ørnstrand Ane Petrea 
Published: November 2023

Inden for de senere år har moderkroppen påkaldt sig en del opmærksomhed. Mange kvinder beskriver efterfødselskroppen som en midlertidig, fremmed og uønsket fysisk tilstand. Denne opfattelse afspejles populærkulturelt i diverse dameblade, bøger og produkter der forsøger at hjælpe de nybagte mødre med at få deres kroppe tilbage og slippe af med denne uønskede version. Idealet er, at blive en Yummy Mummy. 1
Men med et stadigt stigende fokus på den uperfekte krop i populærkulturen og i kunsten, er den “uskønne” efterfødselskrop kommet på den visuelle dagsorden og eksponeres nu mere end nogensinde før. På trods af eksponeringen, kan der spores en dualisme hos mødrene, der på den ene siden et ønsker “ikke at ligne en mor” og på den anden side har en stolthed forbundet med moderskabets manifestation i den krop der har bragt deres barn til verden.
Men hvad med de mødre, der ikke får deres børn med hjem? Hvor efterfødselskroppen ik- ke kun er et uskønt tegn på moderskabet, men også en fysisk markør på sorgen, og en konstant påmindelse om det usynlige moderskab? Artiklens formål er at italesætte efterfødsels- kroppens visuelle diskurs og i forlængelse af dette at pege på den sørgende moderkrop som en central, men tabubelagt og overset materia- litet. Artiklen vil først pege på den dualistiske kropsopfattelse der er på spil hos nybagte mødre og dernæst vise hvordan disse spændinger og det kropslige tabu forstærkes og kompliceres yderligere, når kroppen mister.

1 Et slangudtryk til at beskrive unge attraktive mødre. Udtrykket kom frem i slutningen af det 20. århundrede og blev ofte brugt til at beskrive berømte mødre som hurtigt fik deres præ-gravide kroppe tilbage efter de havde født.
Strategies for Management of Pink Boll Worm Pectinophora gossypiella (Saunders) in Cotton through Different Methods
Authors: Narendar G. , Madhushekar B. R. , Kumar K. Avil 
Published: November 2023

The present study of experiment entitled on the strategies for management of pink boll worm Pectinophora gossypiella (Saunders) in cotton though different methods was conducted in famers fields as a form of Frontline Demonstration (FLD). The experiment was conducted in 30 locations in Nalgonda and Yadadri bhuvangiri distrits of Telangana during kharif 2018, 2019 and 2020 respectively. The results revealed that, due to the adoption of IPM practices in addition to good agricultural practices, the average kapas yield was high in IPM demonstration plots (1857.0 kg/ha) with 12.0% increase over the farmers’ practice (1658 kg/ha) during three years of study.
The average gross returns of Rs.1,01,007/ha, net returns of Rs.52,027/ha, and Benefit-cost ratio of 2.05 was recorded as higher in the demonstration plot as compared to farmers practice Rs. 90,121/ha, Rs.37,430 and 1.69 respectively during the study period. The additional average net returns of Rs.14,597/ha and reduction in the cost of cultivation of Rs.1912/ha were saved per year.
Reaction Kinetic Modeling of the Synthesis of Polymers of Intrinsic Microporosity
Authors: Kandelhard Felix , Neumann Silvio , Lützow Karola , Filiz Volkan , Georgopanos Prokopios 
Published: January 2025

AbstractPolymers of intrinsic microporosity porosity (PIMs) represent a versatile class of materials first discovered over 20 years ago. Despite extensive studies resulting in the optimization of their synthesis, the underlying reaction kinetics have never been the focus of research. This study presents a detailed examination of the reaction kinetics involved in the low‐temperature PIM‐1 synthesis, combining online reaction calorimetry with offline characterization techniques. A reaction kinetic model that describes both the initial deprotonation and the subsequent polycondensation of PIM‐1 is developed. Parameter estimation based on experimental data, followed by comprehensive sensitivity analysis, provides valuable insights into the synthesis process. This model can be applied to further optimize the synthesis process, enhancing both product properties and space‐time yield.
High‐Throughput Design of 2D Coating Materials for the Corrosion Protection of Copper
Authors: Fu Zhongheng , Gu Zewei , Legut Dominik , Chen Xiang , Zhang Dawei , Zhang Ruifeng 
Published: January 2025

Abstract2D coating materials represent a promising class of corrosion protection technologies for copper. The high‐throughput screening methodology, focusing on specific coating properties, is promisingly expected to expedite the design and development of 2D coating materials. Herein, the key features of 2D coating materials, including thermodynamic stability, electronic insulation, strong internal chemical bonds, weak interfacial adhesion, and resistance to corrosive medium adsorption, are identified based on a mechanistic analysis of established 2D coating materials. An automated workflow is formulated, encompassing heterostructure modeling, adsorption site selection, and lattice deformation assessments, to facilitate the high‐throughput derivation of the physical and chemical properties pertinent to coating applications. Among the 13 2D materials exhibiting weak interfacial adhesion and adsorption resistance to Cl, nine are fluorides, suggesting their substantial potential for coating applications. Furthermore, from an extensive pool of 15733 monolayer 2D materials and 11184 bilayer 2D materials, three monolayer 2D materials (IrSCl, IrSF, and TiNF) and four bilayer 2D materials (PdF‐1, PdF‐2, PdF‐3, and SiF‐2) are filtered out for 2D coating materials. These findings not only present promising candidates for 2D coating materials but also contribute valuable theoretical perspectives, guiding the rational design of 2D materials with targeted properties.
Hydrogen Bond Competition Optimizing Aqueous Zn Ion Solvation and (002) Interfacial Deposition with Ultralong Stability
Authors: Xiao Zhe , Dai Xiangyu , Zhu Jianfang , Liu Dongming , Liu Luzhi , Liu Xueping , Li Yun , Qian Zhengfang , Wang Renheng 
Published: January 2025

AbstractAqueous zinc‐ion batteries have garnered significant interest due to their inherent safety, cost‐effectiveness, and high capacity. However, water molecules in the electrolyte adsorb onto the surface of the negative zinc electrode via hydrogen bonding and dissociate into H+ and OH− under an electric field. This creates a local alkaline environment at the interface, promoting zinc dendrite growth, surface corrosion, and hydrogen evolution reaction. Herein, a hydrogen bond competition strategy for optimizing aqueous electrolytes based on low‐cost polyhydroxyl organic additive maltitol is proposed. The addition of maltitol disrupts the hydrogen bond network of the aqueous electrolyte and reduces the activity of water molecules, replacing one of the water molecules in the solvation structure [Zn(H2O)6]2+. Additionally, maltitol preferentially adsorbs on the Zn (002) surface compared to water molecules. This stable deposition of the Zn (002) crystal faces inhibits dendrite growth and hydrogen evolution. The Zn||Zn symmetric battery assembled with 0.4 m maltitol has an ultralong cycle time of 4500 h at 1 mA cm−2, 1 mAh cm−2. Zn||NH4V4O10 full batteries also show better cycling performance than non‐additive devices.
Regio‐Selective Mechanical Enhancement of Polymer‐Grafted Nanoparticle Composites via Light‐Mediated Crosslinking
Authors: Kim Kyungtae , Grummon Benjamin C. , Thrasher Carl J. , Macfarlane Robert J. 
Published: January 2025

AbstractPolymer‐brush‐grafted nanoparticles (PGNPs) that can be covalently crosslinked post‐processing enable the fabrication of mechanically robust and chemically stable polymer nanocomposites with high inorganic filler content. Modifying PGNP brushes to append UV‐activated crosslinkers along the polymer chains would permit a modular crosslinking strategy applicable to a diverse range of nanocomposite compositions. Further, light‐activated crosslinking reactions enable spatial control of crosslink density to program intentionally inhomogeneous mechanical responses. Here, a method of synthesizing composites using UV‐crosslinkable brush‐coated nanoparticles (referred to as UV‐XNPs) is introduced that can be applied to various monomer compositions by incorporating photoinitiators into the polymer brushes. UV crosslinking of processed UV‐XNP structures can increase their tensile modulus up to 15‐fold without any noticeable alteration to their appearance or shape. By using photomasks to alter UV intensity across a sample, intentionally designed inhomogeneities in crosslink density result in predetermined anisotropic shape changes under strain. This unique capability of UV‐XNP materials is applied to stiffness‐patterned flexible electronic substrates that prevent the delamination of rigid components under deformation. The potential of UV‐XNPs as functional, soft device components is further demonstrated by wearable devices that can be modified post‐fabrication to customize their performance, permitting the ability to add functionality to existing device architectures.
Self‐assembled Gap‐Rich PdMn Nanofibers with High Mass/Electron Transport Highways for Electrocatalytic Reforming of Waste Plastics
Authors: Liu Songliang , Ma Kun , Teng Huaifang , Miao Weixin , Zhou Xiaotong , Cui Xuejing , Zhou Xin , Jiang Luhua , Guo Shaojun 
Published: January 2025

AbstractInnovating nanocatalysts with both high intrinsic catalytic activity and high selectivity is crucial for multi‐electron reactions, however, their low mass/electron transport at industrial‐level currents is often overlooked, which usually leads to low comprehensive performance at the device level. Herein, a Cl−/O2 etching‐assisted self‐assembly strategy is reported for synthesizing a self‐assembled gap‐rich PdMn nanofibers with high mass/electron transport highway for greatly enhancing the electrocatalytic reforming of waste plastics at industrial‐level currents. The self‐assembled PdMn nanofiber shows excellent catalytic activity in upcycling waste plastics into glycolic acid, with a high current density of 223 mA cm−2@0.75 V (vs RHE), high selectivity (95.6%), and Faraday efficiency (94.3%) to glycolic acid in a flow electrolyzer. Density functional theory calculation, X‐ray absorption spectroscopy combined with in situ electrochemical Fourier transform infrared spectroscopy reveals that the introduction of highly oxophilic Mn induces a downshift of the d‐band center of Pd, which optimizes the adsorption energy of the reaction intermediates on PdMn surface, thereby facilitating the desorption of glycolic acid as a high‐value product. Computational fluid dynamics simulations confirm that the gap‐rich nanofiber structure is conducive for mass transfer to deliver an industrial‐level current.
Self‐Regulatory Lean‐Electrolyte Flow for Building 600 Wh Kg−1‐Level Rechargeable Lithium Batteries
Authors: Shi Zhepu , Hao Peng , He Yangcai , Zhang Yibin , Hu Shoulei , Shen Yanbin , Gu Qingwen , Zhang Ling , Chen George Zheng , Hu Di , Liu Zhaoping , Qiu Bao 
Published: January 2025

AbstractReducing excess electrolytes offers a promising approach to improve the specific energy of electrochemical energy storage devices. However, using lean electrolytes presents a significant challenge for porous electrode materials due to heterogeneous wetting. The spontaneous wetting of nano‐ or meso‐pores within particles, though seldom discussed, adversely affects wetting under lean electrolyte conditions. Herein, this undesired wetting behavior is mitigated by enlarging the pore‐throat ratio, enabling Li‐rich layered oxide to function effectively at very low electrolyte/capacity (E/C) ratio of 1.4 g Ah−1. The resulting pouch cell achieves 606 Wh kg−1 and retains 80% capacity (75% energy) after 70 cycles. Through imaging techniques and molecular dynamics simulations, it is demonstrated that the pore‐throat ratio effectively determines the permeability of electrolyte within particles. By elucidating pore‐relating mechanisms, this work unveils promising potential of manipulating pore structures in porous electrode materials, an approach that can be applied to improve the specific energy of other devices including semi‐solid‐state lithium batteries.