bluuebunny/crossref_metadata_2025_split huggingface dataset:
TCM and related active compounds in the treatment of gout: the regulation of signaling pathway and urate transporter
Authors: Sun Xin , Yang Le , Sun Hui , Sun Ye , Wei Shuyun , Han Ying , Wang Wenkai , Kong Ling , Wang Xijun 
Published: November 2023

Gout represents a metabolic ailment resulting from the accumulation of monosodium urate crystals within joints, causing both inflammation and, harm to tissues. The primary contributor to gout’s emergence is an elevated presence of serum urate, which is under the regulation of kidney and, gut urate transporters. Mitigating this risk factor is crucial for averting gout’s onset. Several treatments rooted in TCM and related active compounds have demonstrated efficacy in managing gout, skillfully regulating serum uric acid (UA) levels and curbing inflammation’s progression. This analysis compiles key foundational research concerning the molecular signaling pathways and UA transporters linked to gout, under the regulation of TCM. The focus includes individual botanical drug, active compounds, and TCM formulations, which have been consolidated and examined in this overview. The primary keywords chosen were “gout, hyperuricemia, gouty arthritis, traditional Chinese medicine, Chinese botanical drug, medicinal botanical drug, and natural plant”. Various relevant literature published within the last 5 years were gathered from electronic databases, including PubMed, Web of Science, CNKI, and others. The findings revealed that TCM has the capacity to modulate various signaling pathways, including MAPK, NF-κB, PI3K/Akt, NLRP3 and JAK/STAT. Additionally, it impacts UA transporters like URAT1, GLUT9, ABCG2, as well as OATs and OCTs, thereby contributing to gout treatment. TCM helps maintain a balanced inflammatory interaction and facilitates UA excretion. This study enhances our understanding of TCM’s anti-gout mechanisms and introduces novel perspectives for establishing the clinical significance and future prospects of TCM-based gout treatment.
Sex differences in the factors that affect medical lethality in elderly suicide attempters
Authors: Kim HeungKyu , Min Seongho , Ahn Joung-Sook , Kim Hyun , Cha Yong Sung , Lee Jinhee , Kim Min-Hyuk 
Published: November 2023

ObjectivesThis study aimed to identify sex differences in the factors that affect medical lethality in elderly suicide attempters.MethodsA total of 253 elderly suicide attempters and 351 middle-aged attempters (comparison group) who visited the emergency room at a general hospital were included. The sociodemographic and clinical characteristics of the patients were investigated. The Chi-squared test and logistic regression analysis were performed. And Spearman’s correlation coefficient was calculated.ResultsIn older males, the risk of high lethality was lower when attempting suicide due to the loss of family members [adjusted odds ratio (AOR): 0.08]. The risk increased as the intent to die became more certain (some AOR: 11.31, certain AOR: 28.75), and this association became more pronounced with age (rho middle-aged: 0.329; young-old: 0.387; old-old: 0.415). In older females, the risk was lower when employed (AOR: 0.28). The method of suicide attempt also affected lethality (agricultural chemicals AOR: 3.71; psychiatric medication AOR: 0.31).ConclusionSex differences in the factors that affect medical lethality were identified among elderly suicide attempters. In particular, medical lethality can be predicted by the degree of suicide intention in older males. These findings will help to establish more efficient preventive strategies with specific targets.
Association between Life’s simple 7 and rheumatoid arthritis in adult Americans: data from the National Health and nutrition examination survey
Authors: Wang Jie , Xing Fei , Sheng Ning , Xiang Zhou 
Published: November 2023

ObjectiveThe study aimed to investigate the relationship between Life’s Simple 7 (LS7) and the risk of rheumatoid arthritis (RA) in adult Americans.MethodsA total of 17,532 participants were included in this study. The association between LS7 and the risk of RA was assessed using a weighted logistic regression model, with odds ratios (ORs) and 95% confidence intervals (CIs) calculated. Moreover, the nonlinear relationship was further characterized through smooth curve fitting (SCF) and weighted generalized additive model (GAM) analysis.ResultsAfter adjusting for all covariates, the weighted logistic regression model demonstrated that the LS7 was negatively correlated with the risk of RA. Compared to quintile 1 of LS7, the OR between the risk of RA and quartile 4 of LS7 (LS7.Q4) was 0.261 (95% CI, 0.203, 0.337) in males under 50 years old, while in females of the same age group, the OR was 0.183 (95% CI, 0.142, 0.234). For females aged between 50 and 70 years old, the OR between the risk of RA and LS7.Q4 was 0.313 (95% CI, 0.264, 0.371). In females aged 70 years or older, the OR between the risk of RA and LS7.Q4 was 0.632 (95% CI, 0.486, 0.822).ConclusionThis finding suggested the healthy lifestyle behaviors represented by LS7 have a negative association with RA. However, further prospective studies are needed to verify the causal relationship in the results.
Promoting physical activity and a healthy active lifestyle in community-dwelling older adults: a design thinking approach for the development of a mobile health application
Authors: Daniels Kim , Lemmens Ryanne , Knippenberg Els , Marinus Nastasia , Vonck Sharona , Baerts Jan , Bergs Jochen , Spooren Annemie , Hansen Dominique , Bonnechère Bruno 
Published: November 2023

BackgroundPhysical activity (PA) has wide-ranging, and well documented benefits for older adults, encompassing physical, cognitive, and mental well-being. The World Health Organization advocates for a minimum of 150–300 min of moderate intensity PA per week, supplemented by muscle-strengthening exercises. However, the rates of PA among older adults remain a concern. While portable technologies hold promises in promoting PA, sustaining long-term engagement continues to be a challenge.ObjectiveThe aims of this study are to identify barriers and facilitators to PA in older adults, to develop an mHealth app promoting PA and an active healthy lifestyle in collaboration with community-dwelling older adults guided by the design thinking process, and to test it.MethodsA co-creative process was used, employing design thinking. Interviews were conducted to understand the needs of the target population and identify the problem of insufficient PA. Two cocreation sessions involving older adults and experts were conducted to generate innovative ideas. Participants were selected based on age (≥65 years), no severe illness, Dutch language proficiency, and active participation ability. Results were qualitatively analyzed and coded. Finally a prototype was developed and tested.ResultsInterviews with older adults highlighted diverse perceptions of PA but unanimous agreement on its importance. They recognized health benefits such as improved mobility, balance, and reduced fall risk, while emphasizing the social and mental aspects. Barriers included poor health, time constraints, weather conditions and fear of falling. Cocreation sessions identified key topics: perception of a healthy lifestyle, coping strategies, mHealth App features, screen visualization, and tailored notifications, which led to the development of a mobile app promoting PA and an active lifestyle. The app was stepwise prototyped.ConclusionThis study emphasizes the importance of promoting PA among older adults through a collaborative design thinking approach. However, the implementation of mHealth apps faces obstacles due to the digital divide, necessitating personalized solutions to bridge the gap. Moreover, it calls for further research to investigate the long-term impact of such interventions and explore behavior change patterns in this population.
Glucagon- and insulin-immunopositive endocrine cells in porcine extrahepatic bile ducts and gallbladder
Authors: Stefanov Ivaylo Stefanov , Stefanov Stefan Ivaylov , Gulubova Maya Vladova 
Published: November 2023

IntroductionPancreatic β-cells and α-cells have been found in the murine extrahepatic biliary ducts but not in the gallbladder. However, there has been no information reported in the specialized literature about the presence of glucagon- and insulin-expressing endocrine cells in porcine bile ducts and gallbladder.AimWe aimed to perform an immunohistochemical study to identify glucagon- and insulin-positive cells and their distribution in the porcine extrahepatic biliary ducts and gallbladder.MethodThe immunohistochemical method was used to detect the presence and distribution of glucagon- and insulin-positive endocrine cells in the common hepatic duct (ductus hepaticus communis), common bile duct (ductus choledochus), cystic duct (ductus cysticus), and gallbladder (vesica fellea) of male pigs. Chromogranin A was used as a typical marker for endocrine cells.ResultsThe density of chromogranin A-, glucagon- and insulin-positive cells per field was the largest in the common bile duct, followed by the common hepatic duct, cystic duct, and gallbladder. The three types of endocrine cells showed specific localization in the superficial and deep glands of the studied organs.Conclusion and clinical importanceThe distribution of glucagon- and insulin-immunopositive endocrine cells in the porcine extrahepatic biliary tract was established for the first time as a new source of these hormones. The presence of α- and β-cells in the epithelium of extrahepatic bile ducts can be applied in treatment of diabetes, taking into account the possibility to reprogram the biliary epithelium to mentioned pancreatic endocrine cell types.
Time series analysis and forecasting of the number of canine rabies confirmed cases in Thailand based on national-level surveillance data
Authors: Punyapornwithaya Veerasak , Thanapongtharm Weerapong , Jainonthee Chalita , Chinsorn Pornpiroon , Sagarasaeranee Onpawee , Salvador Roderick , Arjkumpa Orapun 
Published: November 2023

IntroductionRabies, a deadly zoonotic viral disease, accounts for over 50,000 fatalities globally each year. This disease predominantly plagues developing nations, with Thailand being no exception. In the current global landscape, concerted efforts are being mobilized to curb human mortalities attributed to animal-transmitted rabies. For strategic allocation and optimization of resources, sophisticated and accurate forecasting of rabies incidents is imperative. This research aims to determine temporal patterns, and seasonal fluctuations, and project the incidence of canine rabies throughout Thailand, using various time series techniques.MethodsMonthly total laboratory-confirmed rabies cases data from January 2013 to December 2022 (full dataset) were split into the training dataset (January 2013 to December 2021) and the test dataset (January to December 2022). Time series models including Seasonal Autoregressive Integrated Moving Average (SARIMA), Neural Network Autoregression (NNAR), Error Trend Seasonality (ETS), the Trigonometric Exponential Smoothing State-Space Model with Box-Cox transformation, ARMA errors, Trend and Seasonal components (TBATS), and Seasonal and Trend Decomposition using Loess (STL) were used to analyze the training dataset and the full dataset. The forecast values obtained from the time series models applied to the training dataset were compared with the actual values from the test dataset to determine their predictive performance. Furthermore, the forecast projections from January 2023 to December 2025 were generated from models applied to the full dataset.ResultsThe findings revealed a total of 4,678 confirmed canine rabies cases during the study duration, with apparent seasonality in the data. Among the models tested with the test dataset, TBATS exhibited superior predictive accuracy, closely trailed by the SARIMA model. Based on the full dataset, TBATS projections suggest an annual average of approximately 285 canine rabies cases for the years 2023 to 2025, translating to a monthly average of 23 cases (range: 18–30). In contrast, SARIMA projections averaged 277 cases annually (range: 208–214).DiscussionThis research offers a new perspective on disease forecasting through advanced time series methodologies. The results should be taken into consideration when planning and conducting rabies surveillance, prevention, and control activities.
The Yield of Routine Post-Operative Doppler Ultrasound to Detect Early Post-Liver Transplantation Vascular Complications
Authors: Minciuna Iulia , den Hoed Caroline , van der Meer Adriaan J. , Sonneveld Milan J. , Sprengers Dave , de Knegt Robert J. , de Jonge Jeroen , Maan Raoel , Polak Wojciech G. , Darwish Murad Sarwa 
Published: November 2023

Early detection of liver transplantation (LT) vascular complications enables timely management. Our aim was to assess if routine Doppler ultrasound (rDUS) improves the detection of hepatic artery thrombosis (HAT), portal vein thrombosis (PVT) and hepatic venous outflow obstruction (HVOO). We retrospectively analysed timing and outcomes, number needed to diagnose one complication (NND) and positive predictive value (PPV) of rDUS on post-operative day (POD) 0,1 and 7 in 708 adult patients who underwent primary LT between 2010–2022. We showed that HAT developed in 7.1%, PVT in 8.2% and HVOO in 3.1% of patients. Most early complications were diagnosed on POD 0 (26.9%), 1 (17.3%) and 5 (17.3%). rDUS correctly detected 21 out of 26 vascular events during the protocol days. PPV of rDUS was 53.8%, detection rate 1.1% and NND was 90.5. Median time to diagnosis was 4 days for HAT and 47 days for PVT and 21 days for HVOO. After intervention, liver grafts were preserved in 57.1%. In conclusion, rDUS protocol helps to detect first week’s vascular events, but with low PPV and a high number of ultrasounds needed.
Farnesoid X Receptor Agonist GW4064 Protects Lipopolysaccharide-Induced Intestinal Epithelial Barrier Function and Colorectal Tumorigenesis Signaling through the αKlotho/βKlotho/FGFs Pathways in Mice
Authors: Liu Hsuan-Miao , Chang Zi-Yu , Yang Ching-Wei , Chang Hen-Hong , Lee Tzung-Yan 
Published: November 2023

The farnesoid X receptor (FXR)/βKlotho/fibroblast growth factors (FGFs) pathway is crucial for maintaining the intestinal barrier and preventing colorectal cancer (CRC). We used an FXR agonist, GW4064, and FXR-knockout (FXR-KO) mice to investigate the role of FXR/Klothos/FGFs pathways in lipopolysaccharide (LPS)-induced intestinal barrier dysfunction and colon carcinogenesis. The results showed that upregulation of FXR in enterocytes effectively ameliorated intestinal tight-junction markers (claudin1 and zonula occludens-1), inflammation, and bile acid levels, thereby protecting mice from intestinal barrier dysfunction and colon carcinogenesis. GW4064 treatment increased FXR, αKlotho, βKlotho, FGF19, FGF21, and FGF23 in wild-type mice exposed to LPS, while FXR-KO mice had decreased levels. FXR-KO mice exhibited elevated colon cancer markers (β-catenin, LGR5, CD44, CD34, and cyclin D1) under LPS, underscoring the pivotal role of FXR in inhibiting the development of colon tumorigenesis. The varying gut microbiota responses in FXR-KO mice versus wild-type mice post LPS exposure emphasize the pivotal role of FXR in preserving intestinal microbial health, involving Bacteroides thetaiotaomicron, Bacteroides acidifaciens, and Helicobacter hepaticus. Our study validates the effectiveness of GW4064 in alleviating LPS-induced disruptions to the intestinal barrier and colon carcinogenesis, emphasizing the importance of the FXR/αKlotho/βKlotho/FGFs pathway and the interplay between bile acids and gut microbiota.
An Application of Touchard Polynomials on Subclasses of Analytic Functions
Authors: Ali Ekram E. , Kota Waffa Y. , El-Ashwah Rabha M. , Albalahi Abeer M. , Mansour Fatma E. , Tahira R. A. 
Published: November 2023

The aim of this work is to discuss some conditions for Touchard polynomials to be in the classes TBb(ρ,σ) and TKb(ρ,σ). Also, we obtain some connection between Rη(D,E) and TKb(ρ,σ). Also, we investigate several mapping properties involving these subclasses. Further, we discuss the geometric properties of an integral operator related to the Touchard polynomial. Additionally, briefly mentioned are specific instances of our primary results. Also, several particular examples are presented.
Audiological Features in Patients with Alpha-Mannosidosis
Authors: Дайхес Н.А. , Мачалов А.С. , Брагина О.Л. , Торопчина Л.В. , Мареев В.В. , Балакина А.В. 
Published: November 2023

Цель. Определить тактику и разработать алгоритм ведения пациентов с нарушением слуха, ассоциированным с альфа-маннозидозом. Материалы и методы. Проведен анализ клинико-аудиологической картины семи пациентов с альфа-маннозидозом в возрасте от 3 до 18 лет. Каждому пациенту было проведено оториноларингологическое и аудиологическое обследование. В объем сурдологического обследования были включены акустическая импедансометрия, тональная пороговая аудиометрия, регистрация задержанной вызванной отоакустической эмиссии, КСВП, ASSR-тест. Результаты. В статье описана клинико-аудиологическая картина семи пациентов с альфа-маннозидозом на различных этапах ведения пациента специалистами в процессе ферментозаместительной терапии (ФЗТ). Согласно полученным нами данным, при обследовании пациентов с альфа-маннозидозом в подавляющем большинстве (85,7%) случаев встречается сенсоневральная потеря слуха, которая может ухудшаться рецидивирующим экссудативным средним отитом, требующим постановки тимпаностомических трубок длительного ношения. Выводы. Поэтому своевременная диагностика нарушений слуха пациентов с альфа-маннозидозом позволит в ранние сроки начать лечение и определить необходимые методы дальнейшей реабилитации, что в свою очередь повысит качество жизни пациентов.
Introduction. Alpha-mannosidosis is one of the many orphan diseases encountered in the practice of an audiologist-otorhinolaryngologist. Among its first manifestations in children, there is a progressive hearing loss due to sensorineurological diseases with recurrent exudative late otitis media. Purpose. To determine the tactics and develop the research algorithm in patients with hearing impairment associated with alpha-mannosidosis. Materials and methods. Clinical and audiological analysis seven patients with alpha-mannosidosis aged from 3 to 18 years old. Each patient underwent an otorhinolaryngological and audiological examination. The volume of the audiological examination included acoustic impedancemetry, audiometry, registration of delayed evoked otoacoustic emission, ABR. Results. The article describes the clinical and audiological picture of seven patients with alpha-mannosidosis for various manifestations of patient management during enzyme replacement therapy (ERT). According to our data, during the exacerbation of patients with alpha-mannosidosis, in the vast majority of cases (85.7%), sensorineural hearing loss occurs, which can worsen with recurrent exudative late otitis, requiring the placement of exacerbation tympanostomy tubes. Conclusions. Therefore, timely diagnosis of cases of hearing in patients with alpha- mannosidosis is likely to be early in the start of treatment and certain methods determine the further development, which, in turn, will improve the quality of life of patients.
USER INTERFACE AND USER EXPERIENCE E-COMMERCE BERBASIS MOBILE
Authors: Tarisa Rani , Kurniawan Fatoni , Sauda Siti 
Published: November 2023

CV. Global Sakti Mandiri merupakan tempat yang menjual berbagai macam alat elektronik dan juga tempat yang menyediakan jasa servis elektornik. Pada penelitian ini menggunkan metode User Centered Design (UCD) sebagai pendekatan yang merupakan konsep dari rancangan melalui pendekatan oleh pengguna sistem, dimana proses perancangan sistem berfokus pada kebutuhan user. Adapun tujuan menggunaan metode ini untuk membantu menentukan kesesuaian antarmuka aplikasi e-commerce berbasis mobile berdasarkan daya tarik oleh pengguna. Prototype ini agar dapat menyesuaikan dengan keinginan dan kebutuhan pengguna. langkah-langkah dari metode user centered design. Penelitian ini akan dimulai dari tahap Specify the context of use, setelah itu ke tahap kedua Specify User and organization requirements, kemudian tahap ketiga Produce design solution, dan terakhir Evaluate design. Hasil penilian ini menggunakan metode system usability scale (SUS) menunjukan skor 73,6 kategori baik, menunjukan bahwa sistem e-commerce memiliki tingkat kemudahan pengguna yang baik. Pengguna merasa bahwa antarmuka dan fungsionalitas mudah digunakan dan dipahami.
Aplikasi Kearifan Lokal Wisata Under Water menggunakan User Centered Design berbasis Android
Authors: Gobel Citra Yustitya , Misrawati Aprilyana Puspa  
Published: November 2023

Wilayah kabupaten Bolaang mongondow selatan memiliki Kearifan Lokal di bidang pariwisata khususnya wisata bahari under water dimana Hasil pengumpulan data dan observasi bahwa jumlah spot diving berjumlah 54 titik dengan keindahan bawah laut yang memikat namun berdasarkan identifikasi masalah bahwa Akses terhadap informasi destinasi dan kegiatan wisata bawah laut masih terbatas, sulitnya akses secara langsung objek wisata karena belum tersedianya aplikasi khusus informasi wisata Under water sehingga tujuan Penelitian ini Merancang aplikasi pelestarian kearifan lokal wisata under water sebagai informasi digital berbasis android untuk memudahkan akses informasi peminat wisata bawah laut yang berkunjung ke lokasi diving dengan pembaharuan informasi secara berkala. Hasil penelitian Untuk mencapai tujuan penelitian yakni menerapkan metode User Centered Desaign dengan hasil penelitian yang diuraikan dalam tahapan Plan Human Centered Desaign Proses, Understand and Specify the Use Context, Specify of User Requirements, Produce Design of Solutions, dan Evaluate Designs User Requirements yang di uji menggunakan metode whitebox menghasilkan V(G) = E – N + 2 = (5 – 6) + 2 = 1. V(G) = (Predicate Node (P) + 1) = 1 + 0 = 1 dan hasil Ciclometic Complexity (CC) = R1 = 1 dan hasil perhitungan SUS memperoleh nilai rata-rata 80 yang berada pada skala good dan Excellent sehingga hasil pengujian menunjukan bahwa Aplikasi yang di rancang sesuai kebutuhan pengguna sistem
Perilaku Hygiene Sanitasi Pedagang Makanan Jajanan di Sekolah Dasar Kecamatan Tanjung Raja Kabupaten Ogan Ilir
Authors: Hikma Nadiah Permata , Amin Maliha , Navianti Diah 
Published: November 2023

Latar Belakang: Sanitasi pada makanan merupakan upaya untuk mengamankan dan menyelamatkan agar makanan tetap bersih, aman dan sehat. Masih ditemukan pedagang makanan yang belum memenuhi standar hygienitas terutama pada makanan jajanan anak di Sekolah Dasar. Faktor-faktor yang mempengaruhi higiene dan sanitasi makanan jajanan, yaitu pengetahuan, penjamah makanan, sanitasi peralatan, sanitasi penyajian. Tujuan Penelitian: Diketahuinya karakteristik responden, pengetahuan, sikap, dan tindakan pedagang makanan jajanan di sekolah dasar Kecamatan Tanjung Raja Kabupaten Ogan Ilir Tahun 2023.
Metode Penelitian: Penelitian ini menggunakan metode penelitian kuantitaif. Jenis penelitian yang digunakan adalah deskriptif dengan pendekatan cross sectional. Populasi penelitian yaitu 30 orang pedangan dengan teknik pengambilan sampel simple total sampling. Penelitian ini dilaksanakan pada bulan Maret-Mei tahun 2023.
Hasil Penelitian: Tingkat pengetahuan kategori tidak baik sebesar 12 responden (40,0%) dan baik sebesar 18 responden (60,0%). Tingkat sikap kategori tidak baik sebesar 16 responden (53,3%) dan baik sebesar 14 responden (46,7%). Tingkat tindakan kategori tidak baik sebesar responden 19 responden (63,3%) dan baik sebesar 11 responden(36,7%).
Kesimpulan: berdasarkan hasil penelitian yang dilakukan tingkat pengetahuan responden kategori tidak baik sebesar (60,0%), tingkat sikap responden kategori tidak baik sebesar (53,3%) dan tingkat tindakan responden kategori tidak baik sebesar (63,3%).