bluuebunny/crossref_metadata_2025_split huggingface dataset:
Hsa_circ_0081065 exacerbates IH-induced EndMT via regulating miR-665/HIF-1α signal axis and HIF-1α nuclear translocation
Authors: Jiang Shan , Xing Xiaowei , Hong Ming , Zhang Xingqian , Xu Fei , Zhang Guang-hao 
Published: January 2024

AbstractCircRNAs play an important role in various physiological and pathological biological processes. Despite their widespread involvement, the function of circRNAs in intermittent hypoxia (IH) remain incompletely understood. This study aims to clarify the molecular mechanism of it in IH. Differentially expressed circRNAs were identified by transcriptome sequencing analysis in intermittent hypoxia (IH) model. GO and KEGG enrichment analys were performed on the identified differentially expressed circRNAs. The circular characteristics of hsa_circ_0081065 in human umbilical vein endothelial cells (HUVECs) were detected by RT-qPCR. The sublocalization of hsa_circ_0081065 was examined by FISH. The effect of hsa_circ_0081065 on endothelial to mesenchymal transition (EndMT) was estimated by detecting the expression of EndMT related markers. Various techniques, including RNA-pull down, RIP, EMSA, dual-luciferase reporter assay and immunofluorescence staining were used to investigate the relationship among hsa_circ_0081065, miR-665 and HIF-1α. A total of 13,304 circRNAs were identified in HUVECs treatment with IH, among which 73 were differentially expressed, including 24 upregulated circRNAs and 49 downregulated circRNAs. Notably, hsa_circ_0081065 demonstrated a significantly upregulation. Hsa_circ_0081065 exhibited the circular characteristics of circRNA and was predominantly localized in the cytoplasm. Knockdown of hsa_circ_0081065 inhibited EndMT. Mechanically, we demonstrated that hsa_circ_0081065 acts as a sponge for miR-665 to up-regulate HIF-1α and exacerbate HIF-1α nuclear translocation in HUVECs. We have demonstrated that hsa_circ_0081065 is significantly upregulated in HUVECs treated with IH. Our findings indicate that hsa_circ_0081065 exacerbates IH-induced EndMT through the regulation of the miR-665/HIF-1α signal axis and facilitating HIF-1α nuclear translocation. These results provide a theoretical basis for considering of EndMT as a potential therapeutic target for OSAHS intervention.
Identification of wheel track in the wheat field
Authors: Zhang Wanhong 
Published: January 2024

AbstractAgriculture machinery navigating along permanent traffic lanes in the farmland may avoid causing extensive soil compaction. However, the permanent traffic lanes are frequently covered up or eliminated by following tillage practices. It is necessary to identify the wheel tracks designed as permanent traffic lanes in order to ensure the agriculture machinery travels along the designated wheel tracks when cultivating the field. This study proposed an identification method of wheel tracks based on the morphological characteristics of wheel tracks and the environmental conditions around the wheel tracks in the wheat fields. The proposed method first utilized the maximum interclass variance to identify the contours of the main part of the wheel track and the shadow regions around the wheel track’s edges. The main part of the wheel tracks was then separated from interference pixels by moving the centerline of the main part of the wheel track, which was derived by skeleton algorithm and curve fitting, towards the right or left edge of the wheel track at a specific distance. In a morphological opening operation, specific linear and circular structural elements were used to segment the shadow regions along the edge of the wheel track. The remaining wheel track was finally recognized by computing the complement of the region identified. After achieving the segmentation of wheel tracks, many reference points near the outside of the wheel track edge in the original image were chosen as fiducial points for evaluating the differences between the actual value and the recognized wheel track edge. The evaluation was based on computing the root mean squared error (RMSE) and the mean absolute error (MAE) of coordinates of reference points and recognized wheel track edge. The results showed that the largest RMSE and MAE were 24.01 pixels (0.0045 m) and 17.32 pixels (0.0032 m), respectively. The low values of RMSE and MAE reveal that the accuracy of the algorithm developed in this study is high, and using this algorithm may segment the wheel track in the wheat field accurately.
Seasonal predictability of the extreme Pakistani rainfall of 2022 possible contributions from the northern coastal Arabian Sea temperature
Authors: Doi Takeshi , Behera Swadhin K. , Yamagata Toshio 
Published: January 2024

AbstractDuring the summer of 2022, Pakistan and northwestern India were hit by an unprecedented spell of heavy rainfall. Despite capturing major tropical climate anomalies, almost all seasonal prediction systems failed to predict the extreme event, far surpassing the 2010 event. While trying to find possible causes of such a failure through an analysis of inter-member anomalies and numerical experiments, we have discovered that the positive sea surface temperature anomalies in the northern coastal Arabian Sea were one of the key factors behind the event. Although the ensemble mean prediction by the original system captured only 7% of the observed precipitation anomalies over Pakistan, the sensitivity experiments, in which the model sea surface temperature in the northern Arabian Sea was nudged to observation, captured about 25% of the observed anomalies. Improving our ability to predict the conditions of the northern Arabian Sea will contribute to better forecasting of extreme rainfall events such as the one experienced in Pakistan in 2022. Further analysis and possible coordinated sensitivity experiments with multi-models are necessary for a better understanding and improving the prediction.
SH3RF2 contributes to cisplatin resistance in ovarian cancer cells by promoting RBPMS degradation
Authors: Gong Ting-Ting , Liu Fang-Hua , Xiao Qian , Li Yi-Zi , Wei Yi-Fan , Xu He-Li , Cao Fan , Sun Ming-Li , Jiang Feng-Li , Tao Tao , Ma Qi-Peng , Qin Xue , Song Yang , Gao Song , Wu Lang , Zhao Yu-Hong , Huang Dong-Hui , Wu Qi-Jun 
Published: January 2024

AbstractPlatinum-based chemotherapy remains one of the major choices for treatment of ovarian cancer (OC). However, primary or acquired drug resistance severely impairs their efficiency, thereby causing chemotherapy failure and poor prognosis. SH3 domain containing ring finger 2 (SH3RF2) has been linked to the development of cancer. Here we find higher levels of SH3RF2 in the tumor tissues from cisplatin-resistant OC patients when compared to those from cisplatin-sensitive patients. Similarly, cisplatin-resistant OC cells also express higher levels of SH3RF2 than normal OC cells. Through in vitro and in vivo loss-of-function experiments, SH3RF2 is identified as a driver of cisplatin resistance, as evidenced by increases in cisplatin-induced cell apoptosis and DNA damage and decreases in cell proliferation induced by SH3RF2 depletion. Mechanistically, SH3RF2 can directly bind to the RNA-binding protein mRNA processing factor (RBPMS). RBPMS has been reported as an inhibitor of cisplatin resistance in OC. As a E3 ligase, SH3RF2 promotes the K48-linked ubiquitination of RBPMS to increase its proteasomal degradation and activator protein 1 (AP-1) transactivation. Impairments in RBPMS function reverse the inhibitory effect of SH3RF2 depletion on cisplatin resistance. Collectively, the SH3RF2-RBPMS-AP-1 axis is an important regulator in cisplatin resistance and inhibition of SH3RF2 may be a potential target in preventing cisplatin resistance.
Mediators of necroptosis: from cell death to metabolic regulation
Authors: Wu Xiaoqin , Nagy Laura E , Gautheron Jérémie 
Published: January 2024

AbstractNecroptosis, a programmed cell death mechanism distinct from apoptosis, has garnered attention for its role in various pathological conditions. While initially recognized for its involvement in cell death, recent research has revealed that key necroptotic mediators, including receptor-interacting protein kinases (RIPKs) and mixed lineage kinase domain-like protein (MLKL), possess additional functions that go beyond inducing cell demise. These functions encompass influencing critical aspects of metabolic regulation, such as energy metabolism, glucose homeostasis, and lipid metabolism. Dysregulated necroptosis has been implicated in metabolic diseases, including obesity, diabetes, metabolic dysfunction-associated steatotic liver disease (MASLD) and alcohol-associated liver disease (ALD), contributing to chronic inflammation and tissue damage. This review provides insight into the multifaceted role of necroptosis, encompassing both cell death and these extra-necroptotic functions, in the context of metabolic diseases. Understanding this intricate interplay is crucial for developing targeted therapeutic strategies in diseases that currently lack effective treatments.
Oxide ion dynamics in hexagonal perovskite mixed conductor Ba7Nb4MoO20: a comprehensive ab initio molecular dynamics study
Authors: Schwaighofer Bettina , Appel Markus , Gonzalez Miguel Angel , Evans Ivana Radosavljevic 
Published: January 2024

This computational study of oxide ion dynamics in Ba7Nb4MoO20 revealed a significant contribution of out-of-plane dynamics to long-range diffusion. Based on this atomic-level understanding of the structure-property relationship, we propose new materials design strategies.
Revisiting instrument segmentation: Learning from decentralized surgical sequences with various imperfect annotations
Authors: Zheng Zhou , Hayashi Yuichiro , Oda Masahiro , Kitasaka Takayuki , Mori Kensaku 
Published: January 2024

AbstractThis paper focuses on a new and challenging problem related to instrument segmentation. This paper aims to learn a generalizable model from distributed datasets with various imperfect annotations. Collecting a large‐scale dataset for centralized learning is usually impeded due to data silos and privacy issues. Besides, local clients, such as hospitals or medical institutes, may hold datasets with diverse and imperfect annotations. These datasets can include scarce annotations (many samples are unlabelled), noisy labels prone to errors, and scribble annotations with less precision. Federated learning (FL) has emerged as an attractive paradigm for developing global models with these locally distributed datasets. However, its potential in instrument segmentation has yet to be fully investigated. Moreover, the problem of learning from various imperfect annotations in an FL setup is rarely studied, even though it presents a more practical and beneficial scenario. This work rethinks instrument segmentation in such a setting and propose a practical FL framework for this issue. Notably, this approach surpassed centralized learning under various imperfect annotation settings. This method established a foundational benchmark, and future work can build upon it by considering each client owning various annotations and aligning closer with real‐world complexities.
Active galactic nuclei and gravitational redshifts
Authors: Padilla N. , Carneiro S. , Chaves-Montero J. , Donzelli C. J. , Pigozzo C. , Colazo P. , Alcaniz J. S. 
Published: January 2024

Context. Gravitational redshift is a classical effect of General Relativity. It has been measured in stars, quasars, and clusters of galaxies.
Aims. We identify the signature of gravitational redshift in the emission lines of active galaxies that is caused by supermassive black holes and compare this signature to what is found for inactive galaxies.
Methods. Using the virial theorem, we estimated gravitational redshifts for quasars from the 14th data release (DR14) of the Sloan Digital Sky Survey (SDSS) and compared them with measured gravitational redshifts from the difference between the redshifts of emission lines of Sydney Australian Astronomical Observatory Multi-object Integral Field (SAMI) galaxies in the central and outer annuli of their integral field spectra.
Results. Firstly, from the full width at half maximum of Hβ lines of 57 Seyfert type I galaxies of the active galactic nucleus (AGN) Black Hole Mass Database, we derive a median gravitational redshift zg = 1.18 × 10−4. Expanding this analysis to 86 755 quasars from DR14 of SDSS, we have a median value zg = 1.52 × 10−4. Then, by comparing the redshifts of 34 lines measured in the central and outer regions of low-ionization nuclear emission-line region galaxies in the SAMI survey, we obtain zg = (0.68 ± 0.09)×10−4, which increases to zg = (1.0 ± 0.1)×10−4 for the Hα and Hβ lines. These numbers are compatible with central black holes of ∼109 solar masses and broad line regions of ∼1 pc. For non-AGN galaxies, the gravitational redshift is compatible with zero.
Pneumologische Rehabilitation im Antragsheilverfahren bei Long COVID
Authors: Rutsch Mercedes , Schüller Per Otto , Buhr-Schinner Heike , Gross Thomas , Deck Ruth 
Published: January 2024

Zusammenfassung
Hintergrund Bei einem Teil von COVID-19-Betroffenen bleiben Symptome und gesundheitliche Beeinträchtigungen über einen längeren Zeitraum bestehen (Long COVID). Längerfristige Krankheitsfolgen können zu erheblichen und dauerhaften Teilhabeeinschränkungen führen. In diesen Fällen können die Betroffenen eine medizinische Rehabilitation in Anspruch nehmen. Aufgrund der Neuartigkeit der COVID-19-Erkrankung ist über den Reha- und Therapiebedarf sowie den gesundheitlichen Nutzen einer spezifischen Rehabilitationsmaßnahme für die Betroffenen wenig bekannt.

Methodik Es wurde eine multizentrische, längsschnittliche Beobachtungsstudie durchgeführt. Eingeschlossen wurden COVID-19-Rehabilitand*innen in der pneumologischen Rehabilitation im Alter von 18–65 Jahren. Eine nach Alter gematchte Vergleichsgruppe (VG) bestand aus Rehabilitand*innen der Indikationen Asthma bronchiale und COPD. Die schriftliche Befragung fand am Anfang und Ende der Rehabilitation sowie 6 und 12 Monate nach der Rehabilitation statt. Zielkriterien waren u.a. Parameter der subjektiven Gesundheit, berufsbezogene Outcomes, Rehabilitationsinhalte und Nachsorgeleistungen.

Ergebnisse Die Stichprobe umfasste N=305 Teilnehmende, davon waren 172 Personen von Long COVID (LC) betroffen und 133 Personen waren der VG zuzuordnen. In der Gesamtstichprobe war ein Drittel der Teilnehmenden männlich und das Durchschnittsalter lag bei 53 Jahren. Die Rehabilitand*innen begannen die Rehabilitation mit hohen gesundheitlichen Ausgangsbelastungen, wobei die LC-Gruppe in nahezu allen erfassten Outcomes teilweise statistisch signifikant höhere Beeinträchtigungen aufwies. Zu Beginn der Rehabilitation war ein Drittel der Befragten krankgeschrieben, LC häufiger als die VG. Zwölf Monate nach der Rehabilitation zeigten sich für beide Gruppen signifikante gesundheitliche Effekte, wobei die LC-Gruppe in den meisten Outcomes die stärkeren Verbesserungen aufwies (Interaktionseffekt p<0,01). Trotz dieser Erfolge wies die LC-Gruppe auch 12 Monate nach der Rehabilitationsmaßnahme starke COVID-Symptome auf. Ein Jahr nach der Rehabilitation kehrten 89% in das Erwerbsleben zurück.

Schlussfolgerungen Die meisten Rehabilitand*innen profitieren gesundheitlich und beruflich in starkem Ausmaß von der pneumologischen medizinischen Rehabilitation. Die Inhalte der pneumologischen Rehabilitation scheinen ansatzweise auch für LC-Patient*innen geeignet zu sein, allerdings zeigt sich eine indikationsspezifische Therapienutzung zwischen VG und LC-Patient*innen. Daraus resultiert, dass LC-Rehabilitand*innen mehr und andere Therapieverfahren zu benötigen scheinen.
In Vitro Assessment of Compression Patterns Using Different Methods to Achieve Interfragmentary Compression during Tibial Plateau Levelling Osteotomy
Authors: Alvarez Rodrigo , Motta Claudio , Miraldo Diogo 
Published: January 2024

Abstract
Objectives The aim of this study was to evaluate and characterize different methods to achieve interfragmentary compression during tibial plateau levelling osteotomy (TPLO).
Study Design TPLO was performed in 20 canine tibia models (Sawbones, Vashon, Washington, United States) using 3D-printed guides for standardization. Interfragmentary compression was assessed using pressure-sensitive films (Prescale, Fujifilm, Atherstone, United Kingdom). Seven compression methods were tested: (1) Kern bone holding forceps clamping the craniodistal aspect of the TPLO plate to the caudal aspect of the tibia (K); (2) using the distal TPLO plate dynamic compression hole (P); (3) pointed bone reduction forceps engaging the caudal aspect of the proximal bone fragment and the cranial aspect of the tibial crest (F); (4) K + P; (5) K + F; (6) F + P; and (7) K + F + P. Five measurements were obtained for each method, and each bone model was used for two measurements (single method, ± plate). The interfragmentary surface was digitalized and divided into quadrants for standardization and pixel density calculation: Q1, craniomedial; Q2, craniolateral; Q3, caudomedial; and Q4, caudolateral. One-way analysis of variance (ANOVA) and post hoc tests were used for statistical analysis.
Results Mean pressures per quadrant differed significantly between methods (p < 0.001). Methods K, F, and P produced more craniomedial, craniolateral, and caudal compression, respectively. Method K resulted in loss of caudal compression (p < 0.001). Method F + P provided the most even distribution of high interfragmentary compression forces. The addition of method K to this construct (K + F + P) marginally increased cranial compression (p = 0.189 for Q1; p < 0.001 for Q2), but reduced compression caudally (p < 0.001).
Conclusion Method F + P provided more even interfragmentary compression. If method K were used, then combined use with method F + P would be recommended.
The effect of viral infection on the Black Sea microalgae Tetraselmis viridis: the role of nutrients and copper ions
Authors: Stelmakh Liudmila V. , Sagadatova Raisa R. , Alatartseva Olga S. 
Published: January 2024

The TvV-SM2 virus, isolated from the coastal waters of the Black Sea, causes lysis of its host, the algae Tetraselmis viridis (Chlorophyta). Under optimal conditions for nutrients, an increase in the initial abundance of algae cells by four times caused a 3-fold reduction in the latent period of viral infection. During the period of the most rapid cell lysis of T. viridis, nitrogen deficiency leads to a decrease in the average daily rate of death of cells affected by the virus by 3.2 times relative to the replete conditions, while in the case of phosphorus deficiency, this process slows down by up to 2.4 times. Under deplete conditions, the rate of cell death was only 34% lower than under replete conditions. The effect of copper ions (100 μg L−1) on the viral suspension for 6 h led to the complete suppression of its activity. In the presence of the host of this virus, its activity is only partially suppressed. As a result, cell lysis under the influence of a viral infection occurred in two stages. The first stage was noted only during the first 6 h of the experiment. The second main stage took place within 78–170 h. This study showed that in conditions of nutrient deficiency and in the presence of copper ions in seawater, the impact of viruses on microalgae will be weaker.
First Secretary Gierek, President Carter, and the president’s Polish interpreter
Authors: Chekin Leonid S. 
Published: January 2024

AbstractDuring President Carter’s visit to Warsaw in 1977, his interpreter into Polish, Steven Seymour, allegedly made major mistakes. American journalists learned of these mistakes from their Polish colleagues and gloated over what they considered erotic overtones in Seymour’s interpretation. There is much literature on this episode, but no author has yet consulted the actual interpretation. I was able to obtain an archived audio recording of the entire episode from the Jimmy Carter Presidential Library and Museum. In this article, I discuss Seymour’s choice of a sentence-by-sentence mode of interpretation and the problems inherent in that mode, classify his errors and inaccuracies, and attempt to uncover the reasons for the exaggerated criticism from the media and the interpreting community. Characteristically, the media paid no attention to the solemn, confident performance of Seymour’s Polish colleague, who interpreted Edward Gierek’s speech into English. The episode is a good testimony to the role of diplomatic interpreters, whose moment of glory only comes when they make a factual or imaginary mistake.
The cultural localization of video games in Iran
Authors: Zoraqi Amir Arsalan , Mousavi Movahede Sadat 
Published: January 2024

Abstract
Localization is the process through which products are tailored to the socio-cultural values of the
recipient locale. This study seeks to shed light on the practice of video games cultural localization in Iran by focusing on two
of the most prominent software localization and publication companies in Iran, namely Parnian and
Gerdoo. Furthermore, identifying the types of content considered inappropriate by the Iranian game
localization supervisory bodies constitutes another aim of the present study. To this end, six officially localized video games
are compared and contrasted with their original English counterparts. As for the results, the modifications were observed at both
diegetic and non-diegetic levels. Modifications revolved around the following themes: religious issues, socio-cultural issues, and
socio-political references linked to Iran’s legal and religious frameworks. Regarding the strategies, the localized video games
were modified by removing the cut scenes, applying graphical changes, and editing out the original soundtrack.
The spacecraft decompression problem
Authors: Atkin Keith 
Published: January 2024

Abstract
This paper describes the problem of determining how gas pressures varies with time inside a punctured pressure vessel. This would be of importance in the context of a holed civil airliner, or the case of a spacecraft struck by a micrometeoroid. The problem is approached both theoretically, and experimentally using a bench-top arrangement in which air is allowed to escape from a plastic bottle via a small orifice. Air pressure is measured by means of a pressure sensor linked to an Arduino microcontroller. The investigation would make an interesting and challenging student project, both theoretically and experimentally.
Effect of Solution Treatment on Mechanical Properties of Inconel 718 Alloy Formed by SLM
Authors: Jiang Jie , Gu Hai , Li Bin , Zhang Jie , Gu Yan 
Published: January 2024

Abstract
Based on SLM forming process, Inconel 718 alloy powder material was used to design and print test parts, and the test parts were treated with solution treatment. This article explored the effects of solution treatment temperature and time on the mechanical properties of Inconel 718 alloy. The results indicate that the solution treatment can effectively improve the tensile strength, yield strength and density of the parts. When the solution treatment temperature increases, the material brittleness becomes larger, and when the solution treatment time prolongs, the material toughness improves. The density of the material increased with the extension of solution treatment time and the increase of temperature.