bluuebunny/crossref_metadata_2025_split huggingface dataset:
Severe polycystic liver disease in a cat
Authors: King Emily M , Pappano Maria , Lorbach Sarah K , Green Eric M , Parker Valerie J , Schreeg Megan E 
Published: December 2023

Case summary Ductal plate malformations (DPMs) are poorly documented in the veterinary literature, particularly those of the polycystic liver disease (PCLD) phenotype. A 13-year-old female spayed cat presented with progressive icterus, abdominal distension, weight loss and elevated liver enzymes. Initial empirical treatment consisting of amoxicillin/clavulanate, ursodiol and later prednisolone was attempted; however, clinical signs progressed. On abdominal ultrasound, numerous large hepatic cystic masses were noted, characterized by an anechoic center with a heterogeneous, hyperechoic wall. A post-mortem examination confirmed numerous hepatic cysts, the larger of which resulted in hemorrhage and subsequent hemoabdomen. Histologically, these cysts were determined to be of biliary origin, and a diagnosis of PCLD was assigned. Relevance and novel information Herein, we present a detailed report of clinical, gross and histologic findings in a cat clinically affected by PCLD. This case demonstrates that cysts present in this congenital disease can ultimately lead to hepatobiliary malfunction and clinical decline via marked expansion of cysts, compression of the liver and hemoabdomen from cyst rupture. DPMs, specifically PCLD, should be considered in cats presenting with multifocal large hepatic cysts.
The Interaction Between Financial Development and Economic Growth: A Novel Application of Transfer Entropy and Nonlinear Approach in Algeria
Authors: Al khatib Abdullah Mohammad Ghazi , Alshaib Bayan Mohamad , Kanaan Ali Mohamad 
Published: December 2023

This study examines the complex interaction between Financial Development (FD) and Economic Growth (EG) in Algeria from 1980 to 2020 using nonlinear modeling techniques. We apply the Non-Linear Causality test with Transfer Entropy, a novel method in this literature, to confirm the nonlinear causality from FD to EG. We also use the Nonlinear Autoregressive Distributed Lag (NARDL) model and the Cumulative Dynamic Multiplier (CDM) to establish the long-run equilibrium and the short-run dynamic relationship between FD and EG. The NARDL results support the Transfer Entropy findings and show that FD has a symmetric impact on EG in both the short and long term. Positive and negative shocks on FD affect EG similarly and the imbalance is corrected in about 6 years. This study provides useful information for policymakers and stakeholders to design policies that promote (EG) and development in Algeria by enhancing FD and mitigating shocks. JEL Codes: C45, C32, E44, O16, O53
Inflation Differential Pass-Through to Exchange Rate: Some Evidence From Pakistan
Authors: Zakaria Muhammad , Tanveer Seemab , Fida Bashir Ahmad , Iftikhar ul Husnain Muhammad 
Published: December 2023

Using regression and wavelet coherence techniques this paper tries to probe the validity of purchasing power parity (PPP) in Pakistan. For this purpose, monthly data is collected for nominal exchange rate and consumer prices of Pakistan and its 23 major trading partners for the flexible exchange rate period 1982M1 to 2020M12. The regression results show that in 12 countries inflation differential significantly positively affect exchange rate. Similarly, Granger causality results reveal that inflation differential causes exchange rates in 12 countries. Wavelet coherency results indicate that there is significant co-movements between inflation differentials and exchange rates in varying time and frequency domains in all countries. These results indicate the partial validity of PPP in Pakistan. These results suggest that by reducing its inflation Pakistan can stabilize its exchange rates. JEL Classifications: C14, E31, F31
Commuting and Acceptance of Worksite Physical Activity Opportunities: Insights From a French University Hospital
Authors: Da Silva Baptiste , Constant Aymery , Brière Marie , Schnebelen Celine 
Published: December 2023

Background: Recent research suggests a need for worksite programs that promote structured physical activity (PA) among hospital staff. The objectives of this study were to assess the hospital employees’ acceptance of PA opportunities that could be implemented at the worksite, and the association between worksite PA and commuting and other sociocognitive factors. Method: Acceptance of seven PA opportunities from the WHO guidelines was correlated with commuting and socio-cognitive factors through an online survey conducted among the workforce of the University Hospital of Angers, France ( N = 6874) between April 25 and May 22, 2022. Results: Only three PA opportunities in the seven proposed reached high approval rates among at least 50% of the 1,427 participants, namely, provide cycle facilities onsite, create a fitness room onsite, and establish partnerships with private associations or sports clubs, albeit rates decreased significantly with commuting distance for the first and the last proposals. The number of approved PA opportunities was positively related to the perceived negative influence of commuting on well-being and self-rated concerns with current PA level. It was negatively related to older age, long commuting, and flexible rest days. Conclusion: Based on these results, we recommend raising PA awareness and self-efficacy before implementing an easily accessible fitness center for employees. Providing cycle facilities and a more walkable environment in the hospital setting while encouraging active traveling between home and work for short commuters could additionally increase the level of physical activity on an equitable and sustainable basis.
Tumor necrosis factor α promotes clonal dominance of KIT D816V+ cells in mastocytosis: role of survivin and impact on prognosis
Authors: Greiner Georg , Witzeneder Nadine , Klein Klara , Tangermann Simone , Kodajova Petra , Jaeger Eva , Ratzinger Franz , Gerner Marlene C. , Jawhar Mohamad , Baumgartner Sigrid , Fruehwirth Karin , Schmetterer Klaus G. , Zuber Johannes , Gleixner Karoline V. , Mayerhofer Matthias , Schwarzinger Ilse , Simonitsch-Klupp Ingrid , Esterbauer Harald , Baer Constance , Walter Wencke , Meggendorfer Manja , Strassl Robert , Haferlach Torsten , Hartmann Karin , Kenner Lukas , Sperr Wolfgang R. , Reiter Andreas , Sexl Veronika , Arock Michel , Valent Peter , Hoermann Gregor 
Published: December 2023

Abstract
Systemic mastocytosis (SM) is defined by the expansion and accumulation of neoplastic mast cells (MCs) in the bone marrow (BM) and extracutaneous organs. Most patients harbor a somatic KIT D816V mutation, which leads to growth factor–independent KIT activation and accumulation of MC. Tumor necrosis factor α (TNF) is a proapoptotic and inflammatory cytokine that has been implicated in the clonal selection of neoplastic cells. We found that KIT D816V increases the expression and secretion of TNF. TNF expression in neoplastic MCs is reduced by KIT-targeting drugs. Similarly, knockdown of KIT or targeting the downstream signaling cascade of MAPK and NF-κB signaling reduced TNF expression levels. TNF reduces colony formation in human BM cells, whereas KIT D816V+ cells are less susceptible to the cytokine, potentially contributing to clonal selection. In line, knockout of TNF in neoplastic MC prolonged survival and reduced myelosuppression in a murine xenotransplantation model. Mechanistic studies revealed that the relative resistance of KIT D816V+ cells to TNF is mediated by the apoptosis-regulator BIRC5 (survivin). Expression of BIRC5 in neoplastic MC was confirmed by immunohistochemistry of samples from patients with SM. TNF serum levels are significantly elevated in patients with SM and high TNF levels were identified as a biomarker associated with inferior survival. We here characterized TNF as a KIT D816V-dependent cytokine that promotes clonal dominance. We propose TNF and apoptosis-associated proteins as potential therapeutic targets in SM.
Peripheral T-cell lymphoma: are all patients high risk?
Authors: Shea Lauren , Mehta-Shah Neha 
Published: December 2023

Abstract
Peripheral T-cell lymphomas (PTCLs) are a heterogeneous group of mature T-cell neoplasms that represent ∼10% of all non-Hodgkin lymphoma. Outcomes for the majority of patients with PTCL are poor, and treatment approaches have been relatively uniform using cyclophosphamide, doxorubicin, vincristine, and prednisone–based therapy. For example, large registry studies consistently demonstrate 5-year overall survival of ∼30% to 40%. However, as our understanding of the biology underpinning the heterogeneity of PTCL improves and as treatments specifically for PTCL are developed, risk stratification has become a more relevant question. Tools including positron emission tomography–computed tomography and minimal residual disease (MRD) monitoring offer the potential for dynamic risk stratification. In this review, we first summarize registry data describing outcomes in the most common subtypes of PTCL: PTCL not otherwise specified, nodal T-follicular helper cell lymphoma including angioimmunoblastic T-cell lymphoma, and anaplastic large cell lymphoma. We describe current clinically based prognostic indices validated for PTCL and highlight emerging tools for prognostication including novel molecular biomarkers, imaging-based metrics, and MRD dynamics.
Whole-genome CRISPR screening identifies molecular mechanisms of PD-L1 expression in adult T-cell leukemia/lymphoma
Authors: Chiba Masahiro , Shimono Joji , Suto Keito , Ishio Takashi , Endo Tomoyuki , Goto Hideki , Hasegawa Hiroo , Maeda Michiyuki , Teshima Takanori , Yang Yibin , Nakagawa Masao 
Published: December 2023

Abstract
Adult T-cell leukemia/lymphoma (ATLL) is an aggressive T-cell malignancy with a poor prognosis and limited treatment options. Programmed cell death ligand 1(PD-L1) is recognized to be involved in the pathobiology of ATLL. However, what molecules control PD-L1 expression and whether genetic or pharmacological intervention might modify PD-L1 expression in ATLL cells are still unknown. To comprehend the regulatory mechanisms of PD-L1 expression in ATLL cells, we performed unbiased genome-wide clustered regularly interspaced short palindromic repeat (CRISPR) screening in this work. In ATLL cells, we discovered that the neddylation-associated genes NEDD8, NAE1, UBA3, and CUL3 negatively regulated PD-L1 expression, whereas STAT3 positively did so. We verified, in line with the genetic results, that treatment with the JAK1/2 inhibitor ruxolitinib or the neddylation pathway inhibitor pevonedistat resulted in a decrease in PD-L1 expression in ATLL cells or an increase in it, respectively. It is significant that these results held true regardless of whether ATLL cells had the PD-L1 3' structural variant, a known genetic anomaly that promotes PD-L1 overexpression in certain patients with primary ATLL. Pevonedistat alone showed cytotoxicity for ATLL cells, but compared with each single modality, pevonedistat improved the cytotoxic effects of the anti–PD-L1 monoclonal antibody avelumab and chimeric antigen receptor (CAR) T cells targeting PD-L1 in vitro. As a result, our work provided insight into a portion of the complex regulatory mechanisms governing PD-L1 expression in ATLL cells and demonstrated the in vitro preliminary preclinical efficacy of PD-L1–directed immunotherapies by using pevonedistat to upregulate PD-L1 in ATLL cells.
Treatment outcomes of complement protein C5 inhibition in 509 UK patients with paroxysmal nocturnal hemoglobinuria
Authors: Kelly Richard J. , Holt Matthew , Vidler Jennifer , Arnold Louise M. , Large Joanna , Forrest Briony , Barnfield Catherine , Pike Alexandra , Griffin Morag , Munir Talha , Muus Petra , Nagumantry Sateesh K. , Varghese Abraham , Davies John R. , Trikha Roochi , Kulasekararaj Austin G. , Mitchell Lindsay , Gandhi Shreyans 
Published: December 2023

Abstract
Paroxysmal nocturnal hemoglobinuria (PNH) is an acquired clonal hematopoietic disorder that occurs on a background of bone marrow failure (BMF). In PNH, chronic intravascular hemolysis causes an increase in morbidity and mortality, mainly because of thromboses. Over the last 20 years, treatment of PNH has focused on the complement protein C5 to prevent intravascular hemolysis using the monoclonal antibody eculizumab and more recently ravulizumab. In the United Kingdom, all patients are under review at 1 of 2 reference centers. We report on all 509 UK patients with PNH treated with eculizumab and/or ravulizumab between May 2002 and July 2022. The survival of patients with eculizumab and ravulizumab was significantly lower than that of age- and sex-matched controls (P = .001). Only 4 patients died of thromboses. The survival of patients with PNH (n = 389), when those requiring treatment for BMF (clonal evolution to myelodysplastic syndrome or acute leukemia or had progressive unresponsive aplastic anemia) were excluded, was not significantly different from that of age- and sex-matched controls (P = .12). There were 11 cases of meningococcal sepsis (0.35 events per 100 patient-years). Extravascular hemolysis was evident in patients who received treatment, with 26.7% of patients requiring transfusions in the most recent 12 months on therapy. Eculizumab and ravulizumab are safe and effective therapies that reduce mortality and morbidity in PNH, but further work is needed to reduce mortality in those with concomitant BMF.
Jak2
V617F
clonal hematopoiesis promotes arterial thrombosis via platelet activation and cross talk
Authors: Liu Wenli , Pircher Joachim , Schuermans Art , Ul Ain Qurrat , Zhang Zhe , Honigberg Michael C. , Yalcinkaya Mustafa , Nakao Tetsushi , Pournamadri Ashley , Xiao Tong , Hajebrahimi Mohammad Ali , Wasner Lisa , Stegner David , Petzold Tobias , Natarajan Pradeep , Massberg Steffen , Tall Alan R. , Schulz Christian , Wang Nan 
Published: December 2023

Abstract
JAK2 V617F (JAK2VF) clonal hematopoiesis (CH) has been associated with atherothrombotic cardiovascular disease (CVD). We assessed the impact of Jak2VF CH on arterial thrombosis and explored the underlying mechanisms. A meta-analysis of 3 large cohort studies confirmed the association of JAK2VF with CVD and with platelet counts and adjusted mean platelet volume (MPV). In mice, 20% or 1.5% Jak2VF CH accelerated arterial thrombosis and increased platelet activation. Megakaryocytes in Jak2VF CH showed elevated proplatelet formation and release, increasing prothrombogenic reticulated platelet counts. Gp1ba-Cre–mediated expression of Jak2VF in platelets (VFGp1ba) increased platelet counts to a similar level as in 20% Jak2VF CH mice while having no effect on leukocyte counts. Like Jak2VF CH mice, VFGp1ba mice showed enhanced platelet activation and accelerated arterial thrombosis. In Jak2VF CH, both Jak2VF and wild-type (WT) platelets showed increased activation, suggesting cross talk between mutant and WT platelets. Jak2VF platelets showed twofold to threefold upregulation of COX-1 and COX-2, particularly in young platelets, with elevated cPLA2 activation and thromboxane A2 production. Compared with controls, conditioned media from activated Jak2VF platelets induced greater activation of WT platelets that was reversed by a thromboxane receptor antagonist. Low-dose aspirin ameliorated carotid artery thrombosis in VFGp1ba and Jak2VF CH mice but not in WT control mice. This study shows accelerated arterial thrombosis and platelet activation in Jak2VF CH with a major role of increased reticulated Jak2VF platelets, which mediate thromboxane cross talk with WT platelets and suggests a potential beneficial effect of aspirin in JAK2VF CH.
The D ~ Sense ex-vivo viability assay application in a patient with stage IV lung adenocarcinoma: a case report
Authors: Zhang Yu , Wu Xiaoyuan , He Ping , Wu Jieyu , Gu Xia , Bendek Matyas , Ötvös Rita , Szekely Laszlo 
Published: December 2023

Abstract
Background
The treatment resistance is a problem for lung cancer. In this study, we used a vitro tissue culturing system to select a new therapy strategy for a patient with tyrosine kinase inhibitors (TKIs) resistance.

Case presentation
A 42-year-old male Asian patient was diagnosed with advanced lung adenocarcinoma harboring an exon 19 deletion in the epidermal growth factor receptor (EGFR) gene. The patient was treated with Gefitinib, resulting in an almost complete remission for over a year. The patient relapsed after 13 months treatment, and received four cycles of chemotherapy. At 20 months, the patient had developed multiple lung metastases and a solitary cerebellar metastasis. An EGFR T790M mutation was identified in the peripheral blood sample. Subsequent treatment with Osimertinib resulted in a complete response of the intracranial metastasis. By 33 months, the patient had developed a mediastinal tumor mass that responded well to local radiotherapy. By 39 months, an EGFR C797S cis-mutation had been identified and the patient was treated with Brigatinib and Cetuximab. By 44 months, the tumor cells from the pleural effusion had been tested for sensitivity against 30 targeted and cytostatic drugs using the D ~ Sense ex-vivo viability assay. The assay identified 8 drugs with moderate to high sensitivity. Combination therapy of Gemcitabin and Lobaplatin had resulted in disease stabilization.

Conclusions
The case showed that individualized treatment aided by D ~ Sense ex-vivo viability assay can be a viable option for patients with advanced lung adenocarcinoma with pleural effusions.
Post-Tonsillectomy Outcomes in Children with Mucopolysaccharidosis and Obstructive Sleep Apnea
Authors: Elwell Zachary , Mancuso David , Wolter Nikolaus E. , Propst Evan J. , Valdez Tulio , Scheffler Patrick 
Published: December 2023

Objective To describe the incidence of respiratory complications, postoperative hemorrhage, length of stay, and cost of care in children with mucopolysaccharidosis (MPS) undergoing adenotonsillectomy (AT). Methods Analysis of the 2009, 2012, and 2016 editions of the Healthcare Cost and Utilization Project Kids’ Inpatient Database (HCUP KID) identified 24,700 children who underwent AT (40 children with MPS). Demographics, respiratory complications, postoperative hemorrhage, length of stay, and total cost were compared across children with and without MPS. Results Children with MPS had a higher likelihood of being male ( P < 0.017). There was a higher rate of respiratory complications in children with MPS compared with children without MPS [6/40 (15%) vs. 586/24,660 (2.4%), P < 0.001], which remained significant after adjusting for sex [adjusted odds ratio 6.88 (95% CI 2.87–16.46)]. There was also a higher risk of postoperative hemorrhage [4/40 (10%) vs. 444/24,660 (1.8%), P < 0.001), with sex-adjusted odds ratio of 5.97 (95% CI 2.12–16.86). Median (IQR) length of stay was increased in children with MPS (3 days, 1–4) compared with children without MPS (1 day, 1–2, P < 0.001). There was an increase in median (IQR) charges for hospital stay in children with MPS compared with their peers [$33,016 ($23,208.50–$72,280.50 vs. $15,383 ($9937–$24,462), P < 0.001]. Conclusions Children with MPS undergoing AT had an increased risk of respiratory complications, postoperative hemorrhage, longer length of stay, and a higher cost of treatment when compared with children without MPS. This information may help inform interventional, perioperative, and postoperative decision making.
Middletown Lives through Middle-Class Eyes: Hillbilly Elegy and the Problem with the “Liberal Media”
Authors: Zechowski Sharon 
Published: December 2023

J.D. Vance does not become Senator Vance without the success of Hillbilly Elegy, his best-selling memoir (and later, film) about growing up in, and getting out of, rural Appalachia. Initially praised by media critics for its ability to challenge middle-class assumptions about the “white working class,” the book assuaged both liberal anxiety and conservative outrage by providing demographically appropriate explanations for the election of Donald Trump. However, the book, feature film and subsequent political campaign are also part of a much larger, lucrative culture industry built upon the commodification and fetishization of the white working class, one driven by middle-class tastes and prejudices. This was most apparent in the promotion of the book and film by the so-called liberal media establishment, represented by the New York Times, The New Yorker, Netflix, Imagine Entertainment, HarperCollins, and Harpo Productions, to name a few. However, the reinforcement of the false binary between liberal and conservative media obscured how the corporate media system helped elect a candidate who will work most certainly against the interests of actual working people, further alienating them from each other and a shared labor platform more generally. Examining Hillbilly Elegy through the five filters of the Propaganda Model will help to explain the ideological and material effects of the corporate media’s agenda upon the growing class divide.
Inflection and derivation as traditional comparative concepts
Authors: Haspelmath Martin 
Published: December 2023

Abstract
This article revisits the distinction between inflectional and derivational patterns in general grammar and discusses the possibility that this well-known distinction is not rooted in the reality of languages, but in the Western tradition of describing languages, through dictionaries (for words, including derived lexemes) and through grammar books (where we often find tables of exemplary paradigms). This tradition has led to rather different terminological treatments of the two kinds of patterns, but from the perspective of a constructional view of morphology, there is no need to incorporate such differences into formal grammatical descriptions. For practical purposes, we need clear and simple definitions of entrenched terms of general linguistics, so the article proposes semantically based (retro-) definitions of inflection, derivation and lexeme that cover the bulk of the existing usage. Finally, I briefly explain why we need sharp definitions of comparative concepts, and why prototype-based and fuzzy definitions of traditional terms are not helpful.
Cadmium exposure and thyroid hormone disruption: a systematic review and meta-analysis
Authors: Chung Seung Min , Chang Min Cheol 
Published: December 2023

Abstract

Introduction
This meta-analysis aimed to analyze the effect of cadmium (Cd) exposure on thyroid hormone disruption.

Content
Databases including PubMed, Embase, Cochrane Library, and Scopus were searched for studies published up to December 14, 2022. Studies evaluating the association between Cd exposure (blood Cd [BCd] or urine Cd [UCd]) and thyroid function (thyroid-stimulating hormone [TSH], free thyroxine [FT4], total triiodothyronine [TT3]) or thyroid autoimmunity (thyroglobulin antibody [TgAb] or thyroperoxidase Ab [TPOAb]) were included.

Summary and Outlook
This systematic review included 12 cross-sectional studies. Cd exposure showed a neutral association with TSH (pooled correlation=0.016, 95 % confidence interval [CI]=−0.013 to 0.045, p=0.277), FT4 (pooled correlation=0.028, 95 % CI=−0.005 to 0.061, p=0.098), and thyroid autoimmunity (pooled odds ratio=1.143, 95 % CI=0.820–1.591, p=0.430). However, Cd exposure showed a positive association with TT3 (pooled correlation=0.065, 95 % CI=0.050–0.080, p<0.001), which was consistent with the BCd and UCd subgroup analyses (pooled correlation=0.053 and 0.081, respectively, both p<0.001). Cd exposure was not associated with TSH, FT4, or thyroid autoimmunity but tended to increase with TT3.