bluuebunny/crossref_metadata_2025_split huggingface dataset:
Kontribusi Budidaya Lebah Kelulut (Trigona itama) Terhadap Pendapatan Anggota Kelompok Tani Hutan Rimbun Lestari di Kabupaten Kampar
Authors: Atika Nurul , Qomar Nurul , Maharani Evy 
Published: January 2024

The Rimbun Lestari Forest Farmers Group in Kampar District has cultivated kelulut bees (Trigona itama) for 5 years, currently the number of cultivated colonies is 110 colonies.This activity of kelulut cultivation has an important role as one of the strategies in in increasing farmer group household income, but not all members are aware of the great contribution of kelulut cultivation to their income.This study aims to: analyze the costs and income of KTH Rimbun Lestari kelulut cultivation and analyze the contribution of kelulut cultivation to the income of KTH Rimbun Lestari members. Collecting data using the method of observation, surveys and literature studies. Taking respondents using the census method. Data analysis in this study included the calculation of the kelulut beekeeping business and the calculation of household income for KTH Rimbun Lestari members. The results of the study show that kelulut beekeeping business run by KTH Rimbun Lestari, costs Rp. 8.734.000 /year and the total net income of the farmer groups is Rp. 102.111.000/year. The contribution to the income of the kelulut beekeeping business run by KTH Rimbun Lestari is 10,14% of total household income.
Tartaric acid new derivatives as prospective and safe alternative to antimicrobials for food products packing
Authors: Mikaelyan Aram R. , Babayan Bella G. , Grigoryan Armen L. , Grigoryan Anna M. , Asatryan Nona L. , Melkumyan Marina A. 
Published: January 2024

Introduction: Multi-drug resistance of pathogens and food spoilage bacteria is one of the most prevalent problems in contemporary science because the microbial adaptation potential is permanently being stimulated by the excessive antibiotic usage by mankind. In this research, seven new derivatives of tartaric acid (TA) were studied. Their high activity against the multi-drug resistant bacteria and the biodegradation potential by soil microflora was demonstrated.Objective: Based on multiple literature data about aldaric acids antimicrobial properties, for combating pan-drug and especially multi-drug resistant pathogenic microbes, natural L-tartaric acid was target-derivatized by cyclohexyl-, phenyl-, benzyl- and ethanolamine- functional groups into complex amino salts and cyclic imides, which have demonstrated the significant bactericidal and bacteriostatic activity against the spoilage agent bacteria, as well as phytopathogenic and human opportunistic pathogens.Results: In vitro analyses of TA ethanolamine- benzyl-, cyclohexyl- and phenyl- imides and complex amino salts have shown that the mentioned substances are highly active agents for combating multi-drug resistant Gram-positive and Gram-negative pathogens and food spoilage microbes, such as: Pseudomonas aeruginosa, Stenotrophomonas maltophilia, Klebsiella pneumonia, Salmonella enteritidis, Staphylococcus aureus, etc. These compounds are biodegradable by P. chlororaphis group non-pathogenic bacteria and their resistance is ensured by genes of nucleoid as well as are not transmitted by plasmids. In silico analyses have demonstrated their alternative mechanism of action. Conclusions: The results suggest that TA new derivatives can be potentially recommended as safe alternative antimicrobials for food packaging.Keywords: tartaric acid imides, tartaric acid complex aminosalts, spoilage microorganisms, antimicrobial activity, multi-drug resistance.
The Association of Body Mass Index with Cognition and Alzheimer’s Disease Biomarkers in the Elderly with Different Cognitive Status: A Study from the Alzheimer’s Disease Neuroimaging Initiative Database
Authors: Li Qin , Zhan Jiehong , Feng Yuxue , Liao Zixuan , Li Xiaofeng ,   for the Alzheimer’s Disease Neuroimaging Initiative
Published: January 2024

Background: The association of body mass index (BMI) with cognition and Alzheimer’s disease (AD) biomarkers of the elderly remains inconclusive. Objective: To investigate the relationship between BMI and cognition as well as AD biomarkers in the elderly with different cognitive status. Methods: Participants with cognitively normal (CN) were included as the CN group. Participants with mild cognitive impairment and mild dementia were included as the cognitive impairment (CI) group. The relationship between BMI and AD biomarkers (cerebrospinal fluid Aβ42 and p-tau181, hippocampal volume [HV]), global cognition (Mini-Mental State Examination [MMSE]), memory, and executive function were explored. Results: In the CI group, BMI was associated with MMSE (β= 0.03, p = 0.009), Aβ42 (β= 0.006, p = 0.029), p-tau181/Aβ42 ratio (β= -0.001, p = 0.011), and HV (β= 0.05, p < 0.001). However in the CN group, BMI exhibited associations with p-tau181 (β= 0.012, p = 0.014) and memory composite score (β= -0.04, p = 0.038), but not with p-tau181/Aβ42 ratio and HV. Moreover, mediation analysis showed that in the CI group, the positive effect of BMI on HV and MMSE score was partially mediated by diastolic blood pressure. Conclusion: The association of BMI with cognition and AD biomarkers varies across different cognitive status. In particular, a lower BMI was associated with worse cognition, higher Aβ burden, and lower HV in individuals with CI. Clinical practice should strengthen the monitoring and management of BMI in patients with AD.
Potential of an mRNA-Based Urine Assay (Xpert® Bladder Cancer Detection1) in Hematuria Patients - Results from a Cohort Study
Authors: Schmitz-Dräger Claudia , Goebell Peter J. , Paxinos Ellen , Bismarck Ekkehardt , Chen Jack , Balakrishnan Priya , Bates Michael , Ebert Thomas , Schmitz-Dräger Bernd J. , Benderska-Söder Natalya 
Published: January 2024

BACKGROUND AND OBJECTIVE: Assessment of patients with hematuria (aH) remains a challenge in urological practice, balancing the benefits of diagnosing a potentially underlying bladder cancer (UCa) against the risks of possibly unnecessary diagnostic interventions. This study analyzes the potential of an mRNA-based urine assay, the Xpert® Bladder Cancer Detection- CE-IVD (Xpert BC-D), in patients with hematuria. MATERIALS AND METHODS: Overall, 368 patients with newly observed painless hematuria and no history of UCa were included in this observational study. Patients received urological workup, including urethrocystoscopy (WLC), upper tract imaging, urine cytology and Xpert BC-D. Patients with positive WLC were recommended to undergo tumor resection (TUR-B). RESULTS: After excluding non-assessable cases, 324 patients were considered for analysis (188 males, 136 females; median age: 61 years). Eight of twenty-eight patients with a positive TUR-B had Ta low grade (LG) tumors; the others were diagnosed with high grade (HG) lesions (Ta: 4, CIS: 2, T1:11, > T1:3). The Xpert BC-D was more sensitive than urine cytology (96% vs. 61%) ( p = 0.002). Increased risk ratios (RR) were observed for gross hematuria, gender, urine cytology, and positive Xpert BC-D (all p < 0.05). Age and positive Xpert BC-D remained independent predictors of UCa in multivariate analysis. Simulating a triage with WLC restricted to patients with positive Xpert BC-D could have saved 240 (74.1%) assessments at the cost of missing one pTa LG tumor. CONCLUSIONS: The results suggest a potential role for Xpert BC-D in preselecting patients with hematuria for either further invasive diagnosis or an alternate diagnostic procedure.
Auricularia polytricha extract exerts SKN-1 and DAF-16 mediated longevity and stress resistance against UV-B exposure in Caenorhabditis elegans
Authors: Sharika Rajasekharan , Verma Kanika , Tencomnao Tewin , Chuchawankul Siriporn 
Published: January 2024

BACKGROUND: Auricularia polytricha (AP) is traditionally known for its medicinal properties, and linoleic acid (LA) is the prominent component in AP. OBJECTIVE: To understand the anti-aging and stress resistance mechanism induced by AP in Caenorhabditis elegans. METHODS: C. elegans (wild-type (N2), transgenic, and mutant strains) were treated with AP and LA and monitored for lifespan and stress resistance through physiological assays, fluorescence microscopy, and qPCR analysis. Molecular docking studies were employed to identify the interaction mode of LA with DAF-16 and SKN-1. RESULTS: Ethanol extract of AP (APE) was non-toxic and could induce an anti-aging mechanism, as it could extend the lifespan of nematode worms. This was dependent on PMK-1 and DAF-16 as APE could not extend the lifespan of these gene-specific mutants apart from extending the expression of these genes in wild-type nematodes, which was evident from qPCR analysis. LA, too, had a similar effect on the lifespan of wild-type and mutant worms, which further supported the findings. Molecular docking studies pointed to the role of DAF-16 and SKN-1 in regulating the effect of APE. APE also exhibited antioxidant and anti-inflammatory mechanisms as it significantly extended the lifespan in worms exposed to UV-B-induced oxidative stress, thereby showing a protective effect. APE could regulate SKN-1, which was evident from qPCR analysis and the fluorescence of skn-1:GFP transgenic strain. Further qPCR analysis of candidate regulatory genes exhibited antioxidant mechanisms induced by APE. CONCLUSION: APE was observed to induce anti-aging efficacy via SKN-1 and DAF-16.
Shock waves modulate corticospinal excitability: A proof of concept for further rehabilitation purposes?
Authors: Guidetti Matteo , Naci Anisa , Cerri Andrea , Pagani Rossella , Previtera Antonino Michele , Priori Alberto , Bocci Tommaso 
Published: January 2024

Background: Focal extracorporeal shock wave therapy (fESWT) is a physical therapy vastly studied and used for various musculoskeletal disorders. However, the effect of fESWT on central nervous system is still to be determined. Objective: To elucidate spinal and supra-spinal mechanisms of fESWT in healthy subjects, in order to widen the spectrum of its clinical applications. Methods: In this quasi-experimental, unblinded, proof-of-concept clinical study, 10 voluntary healthy subjects underwent fESWT and were assessed immediately before (T0), immediately after (T1) and seven days after (T2) the intervention. As neurophysiological outcomes, motor evoked potentials (resting motor threshold, maximal motor evoked potential and maximal compound muscle action potential ratio, cortical silent period, total conduction motor time, direct and indirect central motor conduction time), F-waves (minimal and mean latency, persistence and temporal dispersion) and H-reflex (threshold, amplitude, maximal H reflex and maximal compound muscle action potential ratio, latency) were considered. Results: Resting motor threshold and F-waves temporal dispersion significantly decreased, respectively, from T1 and T2 and from T0 and T2 (for both, p <  0.05). H-reflex threshold increase between T0 and T1. Analysis disclosed a strong negative correlation between Δ3 cortical silent period (i.e., T2 –T1 recordings) and Δ1 Hr threshold (i.e., T1 –T0 recordings) ( r = –0.66, p <  0.05), and a positive strong relationship between Δ3 cortical silent period and Δ3 Hr threshold ( r = 0.63, p <  0.05). Conclusions: fESWT modulates corticospinal tract excitability in healthy volunteers, possibly inducing an early inhibition followed by a later facilitation after one week.
Retinal ganglion cell and microvascular density loss in hereditary spastic paraplegia
Authors: Turski Gabrielle N. , Turski Christopher A. , Grobe-Einsler Marcus , Kobeleva Xenia , Turski Jennifer S. , Holz Frank G. , Finger Robert P. , Klockgether Thomas 
Published: January 2024

Background: Hereditary spastic paraplegia (HSP) is characterized by progressive degeneration of distal axons in the long corticospinal tracts. Loss of retinal cells and microvascular networks has neither been suspected nor investigated. We concurrently examined the retinal microvasculature and retinal layer morphology in patients with HSP to assess whether retinal features may portray disease and its progression. Methods: Fifteen patients with HSP and 30 healthy controls were included in this cross-sectional case-control study. Disease severity was assessed with the Spastic Paraplegia Rating Scale (SPRS). Severity of ataxia was determined by the Scale for the Assessment and Rating of Ataxia (SARA). Retinal microvasculature was measured by means of optical coherence tomography angiography (OCT-A) and morphology of retinal layers using structural OCT. Mixed-effects models were applied for data analysis. Results: HSP patients showed significantly reduced vessel density of the superficial vascular plexus (SVP), reduced ganglion cell layer (GCL) volume, reduced inner plexiform layer (IPL) volume and reduced temporal-inferior peripapillary retinal nerve fiber layer (pRNFL) thickness versus healthy controls. GCL volume reduction correlated significantly with the worsening of visual acuity and higher SARA scores. Conclusions: These findings demonstrate that, in HSP both cells and vascular networks of the retina are compromised. Assessment of the retinal GCL, IPL and SVP may aid in diagnosis and monitoring of disease progression as well as provide novel structural outcome measures for clinical trials.
Development of A Trilingual E-Dictionary for Early Childhood; Indonesia-English-Lampung
Authors: Septiyana Linda , Aneka Aneka , Mandasari Berlinda , Ramadhan Fezka Shella Syafari 
Published: January 2024

The development of this trilingual e-dictionary (Indonesian-English-Lampung) is expected to help children learn multi-languages and make it easier for children to learn Indonesian, English, and Lampung language. This study aimed to develop a trilingual e-dictionary (Indonesia-English-Lampung) for early childhood students’ at TK Pertiwi Metro. The study used a Research and Development approach, where the data were collected through questionnaire and interview. Qualitative data were analyzed using interactive analysis and quantitative data analysis used percentages. The research participants consisted of 25 Kindergarten teachers at TK Pertiwi Metro and TK PKK 1 Yosodadi Metro. The results showed that learning media in the form of e-dictionary is very needed to introduce languages to early childhood. The contents of trilingual e-dictionary consists of three volumes. Volume one consists of five themes: numbers, colors, fruits, vegetables, and animals. Volume two consists of four themes: family, human body, transportation, and profession. Volume three consists of four themes: classroom, bedroom, nature, and time. The total vocabulary of the entire volume is 158 vocabularies. Furthermore, the teachers’ responses toward the trilingual e-dictionary (Indonesia-English-Lampung) showed that 0% expressed disagreed, 10% less agreed, 41% agreed, and 49% strongly agreed. The average score is 3,38 and, if converted on a table with a scale of 4, includes into a very good category. Therefore, a trilingual e-dictionary (Indonesia-English-Lampung) is declared suitable to be used as an interactive media in learning languages for early childhood.
RANCANG BANGUN SISTEM INFORMASI E-LEARNING BERBASIS WEB (STUDI KASUS MI AL-INAYAH DARMINIYAH)
Authors: Indri Indri Mulyani , Vany Terisia  , Muhajir Syamsu  
Published: January 2024

Learning is a process of interaction between educators and students where educators provide knowledge to grow at once develop insight, creativity and mindset of students. website-based e-learning to support the learning process teaching at MI Al-Inayah Darminiyah which can make it easier for students to learn
and provide flexibility to be able to receive learning materials where and anytime without face-to-face contact with the teacher. The method used is the method and UML (Unified Modeling Language) and built using the PHP programming language (Hypertext Preprocessor) and using MySQL as database server as well XAMPP as a web server. Data collection through interviews with teachers and school staff as well as make observations which are then carried out by research literature. The result is that the e-learning website can be used by the admin, teachers and students at MI Al-Inayah Darminiyah in supporting the learning process teaching at the moment. Admins can manage teacher and student accounts, teachers can
easily manage the material and assignments submitted. Student with easily get school notifications as well as materials and assignments delivered by the teacher. This e-learning website helps schools to improve processes learning optimally so that it can further affect improvement academic student achievement because of the convenience for students in accessing the media learning anytime and anywhere in accordance with the school's vision of " Menjadi Sekolah yang Berprestasi dan Berakhlakul Karimah”.
Rancang Bangun Sistem Monitoring Ketinggian Air, Suhu Dan Kekeruahan Air Pada Budidaya Ikan Lele
Authors: Giawa Amonio , R. Tommy Gumelar  , Diana Yusuf  
Published: January 2024

Cultivating catfish is one of the popular fishery farming activities in Indonesia. Catfish is one of the many fish chosen for cultivation because it has a fast growth rate and can live in various air conditions. However, there are several obstacles or loss factors if not addressed quickly, such as if the air level occurs, changes in temperature conditions and also the level of air turbidity which is also not released is always reviewed regularly. This study uses a prototype method that uses system development from pre-existing systems, this writing covers the design and manufacture of hardware and software with the right detection development algorithm. Aims to produce or create a microcontroller-based system that has the ability to detect air level, temperature and air turbidity in ponds with the hope of being able to minimize the risk of losses caused by air conditions in catfish ponds. The system is equipped with an air level detector using an ultrasonic sensor, and is equipped with a DS18B20 sensor which can detect air temperature and a turbidity sensor which is used to detect the level of air turbidity and of course this system is also equipped with a microcontroller to process data from sensors used as input. The output of the air level monitoring system is an LED with red, yellow and green colors, as well as a buzzer as a marker of air level in catfish ponds. The monitoring system for temperature and also turbidity in water pools is a notification system using an I2C LCD that displays readings of sensor values. The monitoring tool has been successfully tested and is expected to be useful for increasing catfish farming results.

Keywords: Arduino Nano, DS18B20 Sensor, Turbidity Sensor
Qualities of good medical teacher as perceived by medical (MBBS) students of a private medical college in Lahore, Pakistan
Authors: Rasheed Muhammad Bilal , Butt Nauman Ismat , Butt Abira Ismat , Ashiq Khubaib , Khan Irfan Rasheed 
Published: January 2024

Introduction: In human societies, teachers play a fundamental role; teacher is more than just an educator. The present research aims to analyze the perceptions of medical (MBBS) students towards the personality traits and qualities of an excellent teacher so that standards can be set for teaching philosophy.
Methodology: This observational cross-sectional study was conducted at Azra Naheed Medical College, Superior University Lahore. After informed consent, 200 medical (MBBS) students of both genders participated in the study. Each student filled out a questionnaire compromising the qualities of an excellent medical teacher.
Result: According to the student responses, the most commonly agreed factor for an excellent medical teacher was 'Medical Teacher uses simple language' reported by 113 (56.5%) students, followed by 'Medical Teacher uses technology' in 107 (53.5%), 'Medical Teacher has command on the subject' in 106 (53.0%), 'Medical Teacher is enthusiastic about the subject' 105 (52.5%), 'Medical Teacher summarizes topic at the end of the lecture' 105 (52.5%), 'Medical Teacher announces topic one week before lecture' 96 (48.0%), Textbooks are allowed by Medical Teacher during lectures' (94 (47.0%), 'Medical Teacher begins class by asking questions related to the topic' 86 (43%), students reported 'Handouts are given to students by medical teacher' 83 (41.5%) and 61 (30.5%) students said 'There are breaks for discussions and group activities for students during class'.
Conclusion: According to medical (MBBS) students, an excellent medical teacher uses simple language technology, has command of the subject, is enthusiastic and summarizes the topic at the end of the lecture.
Prevalence and awareness of polycystic ovarian syndrome among medical students of Karachi, Pakistan
Authors: Khalfe Shazia Abdul Hamid , Rafi Urooj , Fatima Batool 
Published: January 2024

Introduction: PCOS is the most common condition experienced by females of reproductive age across all ethnicities and cultures worldwide. The term "polycystic" refers to several cysts or many cysts, each harboring an immature egg.
Objective: The objective of this study is to determine the prevalence and awareness among female medical students regarding polycystic ovarian symptoms in Karachi.
Methodology: A cross-sectional study was conducted with a sample of 377 medical students, and data was collected using a questionnaire-based survey.
Results: The results revealed that 77.2% of participants showed awareness of PCOS. 10.9% were diagnosed with PCOS, and all of them were taking medication for this syndrome. However, 63.9% had regular menstrual cycles.
Conclusion: Most of the sample population was aware of PCOS. 10.9% were diagnosed with PCOS.
Tinjauan Kaidah-Kaidah Fiqhiyah Terhadap Adat Merariq (Kawin Culik) Pada Tradisi Perkawinan Adat Suku Sasak
Authors: Aprianita Triana 
Published: January 2024

Tradisi Perkawinan merariq yaitu praktik perkawinan dengan melarikan anak gadis orang, tradisi merariq ini merupakan tradisi yang masih eksis sampai saat ini di masyarakat suku Sasak. Tujuan penelitian ini untuk mengetahui adat merariq yang berlaku di masyarakat suku sasak ditinjau dari segi hukum Islam dan hukum adat. Adapun metode penelitian ini bersifat normatif atau penelitian kepustakaan dengan menggambarkan tradisi merariq dalam suku Sasak, tradisi merariq sudah melekat pada masyarakat Lombok karena sudah menjadi bagian dari tradisi masyarakat. Oleh karena itu tidak ada larangan dalam Islam mengenai praktik merariq karena sudah memenuhi kriteria syarat yang bisa dikatakan sebagai suatu kebiasaan yang baik. Tradisi merariq dari perspektif hukum adat adalah bagian yang tak bisa dipisahkan dari masyarakat suku Sasak, hukum adat dihormati dan dihargai oleh masyarakat suku Sasak serta berperan penting dalam menjaga ketertiban dan kerukunan masyarakat antar suku Sasak. Keberadaan budaya merariq ini sesungguhnya tidak lebih dari perwujudan resistensi kaum laki-laki atas dominasi kebudayaan, politik dan ekonomi. Penelitian ini diharapkan dapat menambah kajian literature mengenai adat merariq dan memberikan kontribusi positif bagi kalangan akademisi mengenai adat merariq bahwa tradisi ini merupakan warisan budaya yang perlu dilestarikan.
PELATIHAN KEWIRAUSAHAAN PEMBUATAN MAKANAN RINGAN TAKOYAKI DAN PERHITUNGAN HARGA POKOK PRODUKSI PADA IBU-IBU PKK RT 2 RW 5 PERUMAHAN MUARA SARANA INDAH JETIS MULYOAGUNG DAU MALANG
Authors: Indrayati Indrayati , Djajanto Ludfi , Rachmat Basuki , Utami Kuni , Sumiadji Sumiadji 
Published: January 2024

Entrepreneurship Training in making Takoyaki and calculation of the cost of production is one of the efforts to provide knowledge for PKK mothers to improve nutrition or endurance as well as increase income for PKK mothers in Muara Sarana Indah housing Mulyoagung Dau Malang. This effort to improve nutrition is the responsibility of universities, especially Malang State Polytechnic in order to increase endurance by making their own processed food at a lower cost. This PKM was carried out on July 29 and 30, 2022..