bluuebunny/crossref_metadata_2025_split huggingface dataset:
Ethnopharmacology and phytochemistry of medicinal plants against enterocyte bacteria-linked infections and diarrhoea in some African countries: a systematic review
Authors: Onohuean Hope , Igere Bright E 
Published: November 2023

Abstract

Background
There is a dearth of relevant bioactive translational progress and post-scientific evidence on the ethnopharmacology and phytochemistry of plants with anti-diarrheal potential in Africa. This study synthesized scientific evidence on commonly used African folkloric medicinal plants in the management/control of diarrhoea and antibiotic-resistant enterocyte-infecting bacteria in some African countries.

Main body
Published articles from different databases on folk medicinal plants used in the treatment/management of bacteria-linked enterocyte infections and diarrhoea were reviewed systematically. The ethnopharmacology and phytochemistry of 75 folkloric plant species belonging to 67 families and 58 genera, including Asteraceae (10.45%), Myrtaceae (7.46%), (Anacardiaceae, Celastraceae, Fabaceae and Hydnoraceae) (5.97%) are the most used anti-diarrheal folkloric plants in the region. The minimum inhibitory concentration (MIC) (0.018 mg/ml–8.45 mg/ml) or (39 μg/ml–2000 μg/ml) and 14.35 g/kg–8317.64 mg/kg LD50 on enterocyte bacteria strains. A solo author reported MIC of the pure component 6.25 μg/ml. Tree (38%) and tuber (3%) were the highest and least life forms of the folkloric plants used. Leaves (41%) were the most frequently used for folk preparations, while aerial, fruits, seeds and combination of shoots + leaves (1.45%) were the least used. Fourteen authors’ studies revealed the phytochemical profile, while six further elucidated the bioactive components of the folkloric plants used to manage diarrhoea.

Conclusion
Our findings revealed the antibacterial potency of folkloric plants against diarrhoea and multiple antibiotic-resistant organisms. It suggests a gap in the appropriate documentation, application of such medicinal/folkloric plants, and low post-research advancement of effectively tested plant types or bioactive agents, calling for well-organized future research engagements.
Disclosure in Civil Proceedings in the UK and Kazakhstan: Comparative Analysis
Authors: Satayeva Aizhan 
Published: November 2023

Abstract
The relevance of the chosen problem is conditioned by the need to develop theoretical ideas about the institution of disclosure of documents in the civil procedural legislation of the Republic of Kazakhstan, considering the experience of the UK, which will emphasize the potential of this measure to improve procedural discipline and ensure legal certainty in making court decisions and increase the level of legal culture in Kazakhstan, which may affect the effectiveness of this procedure or this institution in practice. The purpose of this study was to characterize the institute of disclosure of documents in civil proceedings using methods of comparative legal analysis of English contract law and the current legislation of the Republic of Kazakhstan. The methodological basis of the study consists of dialectical method, comparative legal analysis, analysis and synthesis, formal and logical, formal and legal, classification and grouping, and questionnaire methods. There is an urgent need to develop theoretical ideas about the disclosure of documents in the Republic of Kazakhstan, especially in light of the introduction of new elements of disclosure such as pre-trial protocol in the civil process.
The state of knowledge regarding delivering behavior change techniques via short text messages is already quite advanced: A response to “Can behavior change techniques be delivered via short text messages?”
Authors: Correia Simao Sara , Bartlett Yvonne Kiera , French David P 
Published: November 2023

Abstract
Doğru et al. recent study reported developing text messages that attempted to capture each of 93 behavior change techniques (BCTs) in a standardized taxonomy. They found that a panel of experts identified the majority of the messages developed as having good fidelity to the intended BCTs. While this work has clear merit, we do not believe it accurately reflects the large body of existing research in this area. A process of producing text messages to address BCTs that yielded high fidelity has previously been reported. Furthermore, this work showed that messages developed for one behavior can be modified to address another behavior with similarly good fidelity. Importantly, these messages have been shown to successfully change target constructs in an experimental study and are being used in a randomized trial that has recently completed recruitment of over 1000 people with Type 2 diabetes.
A network-based transcriptomic landscape of HepG2 cells uncovering causal gene-cytotoxicity interactions underlying drug-induced liver injury
Authors: Wijaya Lukas S , Gabor Attila , Pot Iris E , van de Have Luca , Saez-Rodriguez Julio , Stevens James L , Le Dévédec Sylvia E , Callegaro Giulia , van de Water Bob 
Published: November 2023

Abstract
Drug-induced liver injury (DILI) remains the main reason for drug development attritions largely due to poor mechanistic understanding. Toxicogenomic to interrogate the mechanism of DILI has been broadly performed. Gene coregulation network-based transcriptome analysis is a bioinformatics approach that potentially contributes to improve mechanistic interpretation of toxicogenomic data. Here we performed an extensive concentration time course response-toxicogenomic study in the HepG2 cell line exposed to 20 DILI compounds, 7 reference compounds for stress response pathways, and 10 agonists for cytokines and growth factor receptors. We performed whole transcriptome targeted RNA sequencing to more than 500 conditions and applied weighted gene coregulated network analysis to the transcriptomics data followed by the identification of gene coregulated networks (modules) that were strongly modulated upon the exposure of DILI compounds. Preservation analysis on the module responses of HepG2 and PHH demonstrated highly preserved adaptive stress response gene coregulated networks. We correlated gene coregulated networks with cell death onset and causal relationships of 67 critical target genes of these modules with the onset of cell death was evaluated using RNA interference screening. We identified GTPBP2, HSPA1B, IRF1, SIRT1, and TSC22D3 as essential modulators of DILI compound-induced cell death. These genes were also induced by DILI compounds in PHH. Altogether, we demonstrate the application of large transcriptome datasets combined with network-based analysis and biological validation to uncover the candidate determinants of DILI.
Evolutionary game analysis of shared parking market diffusion under government management
Authors: Wei Qingqi , Xiao Guomei 
Published: November 2023

Abstract
The imbalance between supply and demand in urban settings poses a significant barrier to the sustainable advancement of urban transportation. Shared parking serves as a viable solution to mitigate these challenges. Nevertheless, for its sustained growth, a regulatory mechanism enforced by the government is imperative. To promote shared parking market diffusion, we construct an evolutionary game model that incorporates the government, enterprises and parking demanders. It explores stabilization strategies for these stakeholders and identifies multiple equilibrium states under different parameter conditions. The results show that the rate and stability of these evolutionary strategies are constrained by the mutual benefits derived by the three parties. Furthermore, such stakeholders are reciprocally influenced by their willingness to engage in shared parking to varying degrees. Government subsidies serve as a determining factor for the strategic choices made by both enterprises and demanders, albeit at different evolutionary rates. Demanders who have a higher value of time tend to park on-street, thereby influencing enterprise strategies. To foster the long-term growth of the shared parking market, the government must enact appropriate subsidy policies, maintain consistent regulations and advocate for increased subsidies for parking demanders to reduce the effect of temporal heterogeneity on parking behavioural choices.
Mechanical loading intensities affect the release of extracellular vesicles from mouse bone marrow‐derived hematopoietic progenitor cells and change their osteoclast‐modulating effect
Authors: Bratengeier C. , Johansson L. , Liszka A. , Bakker A. D. , Hallbeck M. , Fahlgren A. 
Published: November 2023

AbstractLow‐intensity loading maintains or increases bone mass, whereas lack of mechanical loading and high‐intensity loading decreases bone mass, possibly via the release of extracellular vesicles by mechanosensitive bone cells. How different loading intensities alter the biological effect of these vesicles is not fully understood. Dynamic fluid shear stress at low intensity (0.7 ± 0.3 Pa, 5 Hz) or high intensity (2.9 ± 0.2 Pa, 1 Hz) was used on mouse hematopoietic progenitor cells for 2 min in the presence or absence of chemical compounds that inhibit release or biogenesis of extracellular vesicles. We used a Receptor activator of nuclear factor kappa‐Β ligand‐induced osteoclastogenesis assay to evaluate the biological effect of different fractions of extracellular vesicles obtained through centrifugation of medium from hematopoietic stem cells. Osteoclast formation was reduced by microvesicles (10 000× g) obtained after low‐intensity loading and induced by exosomes (100 000× g) obtained after high‐intensity loading. These osteoclast‐modulating effects could be diminished or eliminated by depletion of extracellular vesicles from the conditioned medium, inhibition of general extracellular vesicle release, inhibition of microvesicle biogenesis (low intensity), inhibition of ESCRT‐independent exosome biogenesis (high intensity), as well as by inhibition of dynamin‐dependent vesicle uptake in osteoclast progenitor cells. Taken together, the intensity of mechanical loading affects the release of extracellular vesicles and change their osteoclast‐modulating effect.
Nonobstetric Surgery and Later Childhood Development: Optimal Anesthesia for the Mother-infant Dyad
Authors: Kearns R.J. , Shaw M. , Nelson S.M. 
Published: November 2023

(Anaesthesia. 2023;78:143–146)
While nonobstetric surgery during pregnancy is uncommon (<1%), it can be a serious cause for concern for mother and baby. In 2016, the American Food and Drug Administration cautioned that general anesthesia (GA) use during the third trimester of pregnancy may increase the risk of impaired neurodevelopment in children of mothers exposed. A later randomized trial found no association between short-duration general anesthesia and increased risk of childhood neurodevelopment issues. Given the vulnerable nature of fetuses in utero, the topic of anesthesia use during pregnancy and its impact on children remains a topic of interest and importance.
Preparing for Obstetric Anaesthesia-An Educational Randomized Controlled Trial Comparing E-learning to Written Course Material
Authors: Andersson M.L. , Duch P. , Bessmann E.L. , Lundstrøm L.H. , Ekelund K. 
Published: November 2023

(Acta Anaesthesiol Scand. 2023;67:36–43)
E-learning is becoming more common in postgraduate continual medical education. While many studies have shown the benefits of e-learning and its effectiveness is similar to traditional teaching methods, the studies vary in quality. This study aimed to determine whether e-learning better prepares obstetric anesthesia course participants compared to written course material by assessing precourse knowledge, anxiety level, group performance, and postcourse knowledge.
Maternal Cardiovascular Morbidity Events Following Preeclampsia: A Retrospective Cohort Study
Authors: Meng M.L. , Frere Z. , Fuller M. , Li Y.J. , Habib A.S. , Federspiel J.J. , Wheeler S.M. , Gilner J.B. , Shah S.H. , Ohnuma T. , Raghunathan K. , Krishnamoorthy V. 
Published: November 2023

(Anesth Analg. 2023;136:728–737)
It has been shown that cardiovascular disease is related to preeclampsia. It has also been found that preeclampsia can increase the risk of heart failure, maternal mortality, and other cardiovascular conditions. This study aimed to show the relationship between cardiovascular diseases and preeclampsia in patients.
Comparison of Different Delivery Modalities of Epidural Analgesia and Intravenous Analgesia in Labor: A Systematic Review and Network Meta-analysis
Authors: Wydall S. , Zolger D. , Owolabi A. , Nzekwu B. , Onwochei D. , Desai N. 
Published: November 2023

(Can J Anesth/J Can Anesth. 2023;70:406–442)
There is still no preferred method of delivering neuraxial analgesia to pregnant patients. There are options such as continuous epidural infusion (CEI) and intermittent epidural bolus which can be controlled by a machine (programmed intermittent epidural bolus—PIEB), demand from an anesthesia provider (demand intermittent epidural bolus—DIEB), or the patient themselves (patient-controlled epidural analgesia—PCEA). The use of opioids for labor analgesia is also common in those who cannot receive spinal analgesia. This study aimed to compare the relationship between different analgesia delivery methods on maternal, fetal, and neonatal outcomes.
Manually Controlled, Continuous Infusion of Phenylephrine or Norepinephrine for Maintenance of Blood Pressure and Cardiac Output During Spinal Anesthesia for Cesarean Delivery: A Double-Blinded Randomized Study
Authors: Belin O. , Casteres C. , Alouini S. , Le Pape M. , Dupont A. , Boulain T. 
Published: November 2023

(Anesth Analg. 2023;136:540–550)
Spinal anesthesia (SA) can induce maternal hypotension which may compromise uteroplacental and fetal perfusion. Current practices that counteract SA-induced vasodilation employ a phenylephrine or norepinephrine infusion through computer-controlled, fixed-rate, and manual delivery methods. The current study investigated the hemodynamic effects of continuous infusion of norepinephrine compared with phenylephrine in maintaining cardiac index (CI) during cesarean delivery (CD) under SA.
Successful Surgical Cricothyroidotomy Following an Obstetric “Can’t Oxygenate” Scenario: A Narrative of Enabling Factors
Authors: Hill J.S. , Robinson E. 
Published: November 2023

(Int J Obstet Anesth. 2023;53:103611)
This report involves a case of failed intubation during general anesthesia (GA) during cesarean delivery (CD) followed by a successful surgical cricothyroidotomy and discusses technical and nontechnical factors. A 40 y/o, G3P1 at 28+3 weeks of gestation with blood pressure of 150/100 mm Hg was diagnosed with pre-eclampsia and admitted to the hospital. At 29+0 weeks gestation, the patient reported chest and abdominal pain. Blood pressure readings were 200/120 mm Hg. The patient received oral labetalol, intravenous magnesium, and oral nifedipine. Blood pressure dropped to 146/78 mm Hg, and labs showed normal platelet count and hemoglobin concentration yet slightly elevated alanine aminotransferase and alkaline phosphatase. Five hours later, when a CD was done for fetal indications, the patient’s platelet count was 50×109/L, so the CD was performed under GA.
Altered profiles of circulating cytokines in chronic liver diseases (NAFLD/HCC): Impact of the PNPLA3 I148M risk allele
Authors: Kirchmeyer Mélanie , Gaigneaux Anthoula , Servais Florence A. , Arslanow Anita , Casper Markus , Krawczyk Marcin , Lammert Frank , Behrmann Iris 
Published: November 2023

Background:
Individuals carrying the risk variant p.I148M of patatin-like phospholipase domain-containing protein 3 (PNPLA3) have a higher susceptibility to fatty liver diseases and associated complications, including HCC, a cancer closely linked to chronic inflammation. Here, we assessed circulating cytokine profiles for patients with chronic liver diseases genotyped for PNPLA3.

Methods:
Serum concentrations of 22 cytokines were measured by multiplex sandwich-ELISA. The cohort comprised 123 individuals: 67 patients with NAFLD without cirrhosis (57 steatosis, 10 NASH), 24 patients with NAFLD with cirrhosis, 21 patients with HCC (15 cirrhosis), and 11 healthy controls. Receiver operator characteristic analyses were performed to assess the suitability of the cytokine profiles for the prediction of steatosis, cirrhosis, and HCC.

Results:
HGF, IL-6, and IL-8 levels were increased in patients, with ∼2-fold higher levels in patients with cirrhosis versus healthy, while platelet derived growth factor-BB (PDGF-BB) and regulated on activation, normal T cell expressed and secreted (RANTES) showed lower concentrations compared to controls. Migration inhibitory factor and monocyte chemoattractant protein-1 (MCP-1) were found at higher levels in NAFLD samples (maximum: NAFLD-cirrhosis) versus healthy controls and HCC samples. In receiver operator characteristic analyses, migration inhibitory factor, IL-8, IL-6, and monocyte chemoattractant protein-1 yielded high sensitivity scores for predicting noncirrhotic NAFLD (vs. healthy). The top combination to predict cirrhosis was HGF plus PDGF-BB. Migration inhibitory factor performed best to discriminate HCC from NAFLD; the addition of monokine induced gamma (MIG), RANTES, IL-4, macrophage colony-stimulating factor (M-CSF), or IL-17A as second parameters further increased the AUC values (> 0.9). No significant impact of the PNPLA3

I148M
allele on cytokine levels was observed in this cohort.

Conclusions:
Cytokines have biomarker potential in patients with fatty liver, possibly suited for early HCC detection in patients with fatty liver. Patients carrying the PNPLA3 risk allele did not present significantly different levels of circulating cytokines.
Hypoxia-inducible factor-prolyl hydroxylase inhibitor Roxadustat (FG-4592) reduces renal fibrosis in Dahl salt-sensitive rats
Authors: Naito Yoshiro , Yasumura Seiki , Okuno Keisuke , Asakura Masanori , Tsujino Takeshi , Masuyama Tohru , Ishihara Masaharu 
Published: November 2023

Objective:
Although hypoxia-inducible factor-prolyl hydroxylase (HIF-PH) inhibitors have been developed for the treatment of renal anemia, their effects on cardiac and renal dysfunction remain unknown. We previously reported on Dahl salt-sensitive rats, in a rat model of salt-sensitive hypertension, that exhibited anemia and impaired expression of duodenal iron transporters after the development of hypertensive cardiac and renal dysfunction. Therefore, we investigated the effects of Roxadustat (FG-4592), an HIF-PH inhibitor, on anemia, iron regulation, and cardiac and renal dysfunction in Dahl salt-sensitive rats.

Methods:
Six-week-old male Dahl salt-sensitive rats were fed a normal or high-salt diet for 8 weeks. A further subset of Dahl salt-sensitive rats, that were fed a high-salt diet, was administered Roxadustat for 8 weeks.

Results:
Dahl salt-sensitive rats fed a high-salt diet developed hypertension, cardiac and renal dysfunction, and anemia after 8 weeks of feeding. Roxadustat increased hemoglobin and serum erythropoietin levels in Dahl salt-sensitive rats fed a high-salt diet. With regard to the iron-regulating system, Roxadustat lowered hepatic hepcidin gene expression and increased the gene expression of duodenal iron transporters, such as cytochrome b and divalent metal transporter 1, in Dahl salt-sensitive rats fed a high-salt diet. Roxadustat did not affect the development of hypertension and cardiac hypertrophy in Dahl salt-sensitive rats with a high-salt diet; however, Roxadustat treatment attenuated renal fibrosis in these rats.

Conclusions:
Roxadustat ameliorated anemia with affecting the gene expression of the iron-regulating system, and did not affect cardiac hypertrophy but attenuated renal fibrosis in Dahl salt-sensitive rats fed a high-salt diet.
Improving Nurses' Attitudes Toward Substance Use Disorder
Authors: Manzotti Ashley , Avery-Desmarais Shannon , Ducharme Maria , Elliott Kathleen , Misto Kara 
Published: November 2023

Abstract
Patients with substance use disorder (SUD) encounter many barriers to healthcare, including negative attitudes of healthcare personnel. Compared with other healthcare professions, nurses have been reported as having less tolerant attitudes toward patients with SUD. Knowledge acquisition combined with role support has been shown to improve therapeutic attitudes of nurses toward patients with SUD. Screening, Brief Intervention, and Referral to Treatment (SBIRT) is an evidence-based educational intervention aimed to improve the outcomes of patients at risk and with SUD. SBIRT education has been shown as an effective educational tool with licensed nurses. Therefore, the aim of this study was to evaluate whether a 2-hour educational session on SBIRT (Mitchell et al., 2013) improved the therapeutic attitudes of nurses toward patients with SUD. Peplau's theory of interpersonal relations guided this study with an emphasis on the nurse–patient relationship. A quasi-experimental pretest/posttest design was used to evaluate nurses' attitudes pre and post a 2-hour educational session. Participants included 65 registered nurses employed in a 247-bed teaching hospital in New England. Attitudes were measured before and after the educational session using the 20-item, five-subscale Drug and Drug Problems Perceptions Questionnaire. A paired t test was performed, showing statistically significant improvements in attitudes postintervention. Prior education on SUD significantly correlated with baseline attitudes. A standard regression model, with practice setting, family history of SUD, and prior education as dependent variables, was not predictive of baseline attitudes. The results suggest conducting SBIRT should be considered a mandatory nursing competency, both in undergraduate curriculum and among licensed nurses.
Enhancing Knowledge and Attitudes Regarding Opioid Use Disorder Among Private Primary Care Clinics
Authors: Jassar Sukhwant Kaur , Hundley Amanda , Giesler Amanda 
Published: November 2023

Abstract
Opioid use disorder (OUD) continues to impact communities worldwide. British Columbia specifically declared a public health emergency in April 2016. It is known that patients with OUD often experience barriers in access to care, including limited knowledge and training among providers, as well as persisting stigma in the medical community. The Doctor of Nursing Practice quality improvement project sought to provide barrier-targeted OUD education while using multiple effective teaching methods, such as test-enhanced learning, to family nurse practitioners (FNPs) working among private primary care clinics to assess the impact on knowledge and attitudes. In review of an experience survey, zero participants had received prior education on OUD (N = 7). The Drug and Drug Problems Perceptions Questionnaire was used to assess attitudes. In review of the data, attitudes before receiving education (Mdn = 74) improved after receiving barrier-targeted education (Mdn = 66), W = 0, p < .05. Knowledge was tested at three time points. After a review of unique identifiers, four participant tests were successfully linked. It was found that knowledge after receiving education (M = 7.75, Mdn = 7.5) improved in comparison with baseline knowledge (M = 6, Mdn = 6) and further improved after a 1-month time frame (M = 8.5, Mdn = 8.5). Although the project was limited by sample size, providing education to FNPs who have not received prior education on OUD, and using modalities such as test-enhanced learning, showed a favorable impact on knowledge and attitudes. In light of the opioid epidemic, nursing leaders must continue to actively engage practicing FNPs and students with OUD education. FNPs are well positioned to be champions in this area and may mobilize teams to overcome barriers among private primary care clinics and increase access to care.