bluuebunny/crossref_metadata_2025_split huggingface dataset:
Green IT: environmentally friendly methods for information technology in the future
Authors: Yadav Alka , Manjhvar Amit Kumar , Parte Smita 
Published: November 2023

Abstract
Information technology's (IT) rapid expansion has raised previously unheard-of environmental problems, which have sparked a paradigm shift towards sustainable practises known as "Green IT." This study investigates the intricate topic of green information technology (Green IT) with the goal of reducing the environmental effect of technology-driven activities. This study explores many approaches that include ecologically friendly software development methods, energy-efficient hardware, and conscientious e-waste management, with an emphasis on the critical relationship between technological innovation and ecological conservation. It offers a thorough summary of the effects of Green IT on organisational sustainability and its implications for global ecosystems by combining case studies, industry best practises, and current trends. This study also examines the barriers to broader adoption and offers practical recommendations for promoting an IT environment that is more ecologically conscientious. Looking ahead, this study emphasises how Green IT may change the information technology industry and is a crucial element in creating a sustainable future for the industry.
Single-cell RNA-seq integration unveils liver vulnerability to tumor metastases: insights from myeloid cell characterization in pancreatic cancer liver metastatic
Authors: Ainiwaer Aizier , Qian Zhenwei , Dong Zheng , Lu Ying , Wang Jianxun , Yu Lingxiang , Zhao Qi , Lu Yinying 
Published: November 2023

Abstract
Background: The liver is the predominant metastatic site for diverse cancers, including pancreatic and colorectal cancers, etc. Liver metastasis increases cancer-related mortality, yet we have limited knowledge of the metastatic microenvironment to effectively target this process. Therefore, it is critical to understand the mechanisms underlying how the hepatic host tissues and immune cells differentially influence metastases in different cancers.
Methods: We integrated two single-cell RNA-seq (scRNA-seq) datasets of pancreatic ductal adenocarcinoma (PDAC) and colorectal cancer (CRC), including samples of primary pancreatic cancer (PP), primary colorectal cancer (PC), peripheral blood mono-nuclear cells (PBMC), adjacent normal pancreatic tissue (NPT), liver tissues from pancreatic cancer liver metastasis (P-LM), and colorectal cancer liver metastasis (C-LM). Cell clusters were manually annotated by known markers to demonstrate the cellular compositions of each group. We comparatively analyzed the cell-cell communications and enriched signaling pathways of P-LM and C-LM. The development trajectories of cell clusters were analyzed using Slingshot cell lineage inference algorithm.
Results: In this study, we performed comparative analysis on cellular compositions between P-LM and C-LM and found myeloid cells exhibited a distinct enrichment profile between the two cancer metastases. Fifteen subclusters of 21,777 myeloid cells were recognized, including cell types such as macrophages, monocytes, and dendritic cells (DCs). We found Mph_SPP1, a subset of macrophages associated with angiogenesis and tumor invasion, was more prevalent in the P-LM group, indicating its specific pro-metastasis role in pancreatic cancers. Analysis of the developmental trajectory implied that Mph_SPP1 may progressively be furnished with increased expression of genes regulating endothelium as it evolved from monocytes. Cell-cell communications analysis revealed that Mph_SPP1 potentially interacts with endothelial cells in P-LM via FN1/SPP1-ITGAV/ITGB1, implying this macrophage subset may construct an immunosuppressive liver microenvironment for pancreatic cancer by regulating endothelial cells. We also found that Mph_SPP1 has a prognostic value in pancreatic adenocarcinoma that is not present in colon adenocarcinoma or rectum adenocarcinoma.
Conclusions: We hypothesized that Mph_SPP1 actively creates a fertile environment for tumors when pancreatic cancer metastasizes to the liver and promote cancer invasion in a pro-angiogenetic pattern. Therefore, Mph_SPP1 has the potential to be a target of immunotherapy for liver metastasis in pancreatic cancer. These findings provide a foundation for understanding the immune characteristics of hepatic tumor microenvironment (TME) in patients with liver metastases and new ideas for the precise therapy of liver metastases.
Colloidal aziridinium lead bromide quantum dots
Authors: Bodnarchuk Maryna I. , Feld Leon G. , Zhu Chenglian , Boehme Simon C. , Bertolotti Federica , Avaro Jonathan , Aebli Marcel , Mir Showkat Hassan , Masciocchi Norberto , Erni Rolf , Chakraborty Sudip , Guagliardi Antonietta , Rainò Gabriele , Kovalenko Maksym V. 
Published: November 2023

Abstract
The compositional engineering of lead-halide perovskite nanocrystals (NCs) via the A-site cation represents a lever to fine-tune their structural and electronic properties. However, the presently available chemical space remains minimal since, thus far, only three A-site cations have been reported to favor the formation of stable lead-halide perovskite NCs, i.e., Cs+, formamidinium (FA), and methylammonium (MA). Inspired by recent reports on bulk single crystals with aziridinium (AZ) as the A-site cation, we present a facile colloidal synthesis of AZPbBr3 NCs with narrow size distribution and size tunability down to 4 nm, producing quantum dots (QDs) in the regime of strong quantum confinement. NMR and Raman spectroscopies confirm the stabilization of the AZ cations in the locally distorted cubic structure. AZPbBr3 QDs exhibit bright photoluminescence with quantum efficiencies of up to 80%. Stabilized with cationic and zwitterionic capping ligands, single AZPbBr3 QDs exhibit stable single-photon emission – another essential attribute of QDs. In particular, didodecyldimethylammonium bromide and 2-octyldodecyl-phosphoethanolamine ligands afford AZPbBr3 QDs with high spectral stability at both room and cryogenic temperatures, reduced blinking with a characteristic ON fraction larger than 85%, and high single-photon purity (g(2)(0)=0.1), all comparable to the best-reported values for MAPbBr3 and FAPbBr3 QDs of the same size.
Regulatory Approaches and Strategies for Household Waste Pollution Management in the East River Flood Canal of Semarang City
Authors: Nirwana Muhammad Alfaruq 
Published: November 2023

This article explores regulations and strategies for managing the impact of household waste pollution in the East River Flood Canal of Semarang City. Water, crucial for human and environmental well-being, faces pollution challenges due to human activities. The study focuses on Semarang, where household waste pollution, often discarded along riverbanks, poses environmental threats. Primary data is collected through field interviews, complemented by secondary legal materials using socio-legal research methods. Regional Regulation No. 6 of 2012 addresses waste management in Semarang, aiming to empower residents in waste utilization and economic value creation. Law Number 32 of 2009 emphasizes collaborative efforts to address environmental challenges. Identified impacts of waste pollution include air and water pollution, contributing to flooding. A SWOT analysis suggests strategies such as enhancing stakeholder support, advocating the vision and mission for integrated waste management, establishing communication forums, leveraging ward roles in community counselling, and enhancing resource capacity to shift public perceptions and behaviours in waste management. This research aims to contribute to sustainable waste management practices and environmental preservation. Artikel ini mengeksplorasi regulasi dan strategi pengelolaan dampak pencemaran limbah rumah tangga di Banjir Kanal Sungai Timur Kota Semarang. Air, yang sangat penting bagi kesejahteraan manusia dan lingkungan, menghadapi tantangan polusi akibat aktivitas manusia. Studi ini berfokus di Semarang, dimana pencemaran limbah rumah tangga, yang sering dibuang di sepanjang tepi sungai, menimbulkan ancaman terhadap lingkungan. Data primer dikumpulkan melalui wawancara lapangan yang dilengkapi dengan bahan hukum sekunder dengan menggunakan metode penelitian sosio-legal. Peraturan Daerah Nomor 6 Tahun 2012 mengatur tentang pengelolaan sampah di Kota Semarang yang bertujuan untuk memberdayakan warga dalam pemanfaatan sampah dan penciptaan nilai ekonomi. Undang-Undang Nomor 32 Tahun 2009 menekankan upaya kolaboratif untuk mengatasi tantangan lingkungan hidup. Dampak pencemaran limbah yang teridentifikasi meliputi pencemaran udara dan air, yang berkontribusi terhadap banjir. Analisis SWOT menyarankan strategi seperti meningkatkan dukungan pemangku kepentingan, mendukung visi dan misi pengelolaan sampah terpadu, membentuk forum komunikasi, memanfaatkan peran lingkungan dalam konseling masyarakat, dan meningkatkan kapasitas sumber daya untuk mengubah persepsi dan perilaku masyarakat dalam pengelolaan sampah. Penelitian ini bertujuan untuk berkontribusi pada praktik pengelolaan sampah berkelanjutan dan pelestarian lingkungan.
Egeria densa organic extracts: an eco-friendly approach to suppress Microcystis aeruginosa growth through allelopathy
Authors: Wijesinghe Ashika , Senavirathna Mudalige Don Hiranya Jayasanka , Fujino Takeshi 
Published: November 2023

Abstract

Macrophytes play a significant role in shaping plankton communities by shading, controlling water turbulence, and nutrient availability, while also producing allelochemicals causing varying effects on different organisms. Many researchers have shown that when live macrophytes are present, they inhibit cyanobacteria. However, their widespread use is often limited due to numerous concerns, including invasive characteristics. This study focused on the applicability of Egeria densa extracts to suppress Microcystis aeruginosa. We employed pure water and dimethyl sulfoxide, to obtain compounds from E. densa. The results revealed that E. densa aqueous extracts stimulated M. aeruginosa growth, whereas organic extracts exhibited suppression. Specifically, at low concentrations of organics extracts (0.5 and 1 g/L), after day 4, the growth inhibition was confirmed by significantly higher (p &lt; 0.05) stress levels shown in cells treated with low concentrations. The highest inhibition rate of 32% was observed at 0.5 g/L. However, high concentrations of organic extracts (3 and 6 g/L), showed increased growth compared with control. These results suggest that high concentrations of organic extracts from E. densa potentially suppress allelochemical-induced M. aeruginosa inhibition due to high nutrient availability. In comparison with an aqueous solvent, the use of organic solvent seems to be more effective in efficiently extracting allelochemicals from E. densa.
Short Antimicrobial Peptides: Therapeutic Potential and Recent Advancements
Authors: Sharma Lalita , Bisht Gopal Singh 
Published: November 2023

Abstract:
There has been a lot of interest in antimicrobial peptides (AMPs) as potential next-generation antibiotics.
They are components of the innate immune system. AMPs have broad-spectrum action and are less
prone to resistance development. They show potential applications in various fields, including medicine, agriculture,
and the food industry. However, despite the good activity and safety profiles, AMPs have had difficulty
finding success in the clinic due to their various limitations, such as production cost, proteolytic susceptibility,
and oral bioavailability. To overcome these flaws, a number of solutions have been devised, one of which
is developing short antimicrobial peptides. Short antimicrobial peptides do have an advantage over longer peptides
as they are more stable and do not collapse during absorption. They have generated a lot of interest because
of their evolutionary success and advantageous properties, such as low molecular weight, selective targets,
cell or organelles with minimal toxicity, and enormous therapeutic potential. This article provides an
overview of the development of short antimicrobial peptides with an emphasis on those with ≤ 30 amino acid
residues as a potential therapeutic agent to fight drug-resistant microorganisms. It also emphasizes their applications
in many fields and discusses their current state in clinical trials.
Recent Updates on the Development of Therapeutics for the Targeted
Treatment of Alzheimer’s Disease
Authors: Rajput Shivam , Malviya Rishabha , Bahadur Shiv , Puri Dinesh 
Published: November 2023

Abstract:
Alzheimer's disease (AD) is a complicated, multifaceted, irreversible, and incurable neurotoxic old
age illness. Although NMDA (N-methyl D-aspartate)-receptor antagonists, cholinesterase repressors, and their
pairings have been approved for the treatment, they are useful for short symptomatic relief. Researchers
throughout the globe have been constantly working to uncover the therapy of Alzheimer's disease as new candidates
must be determined, and newer treatment medicines must be developed. The aim of this review is to address
recent advances in medication research along with new Alzheimer's disease therapy for diverse targets.
Information was gathered utilizing a variety of internet resources as well as websites, such as ALZFORUM
(alzforum.org) and clinicaltrials.gov. In contrast to other domains, the proposed medicines target amyloids
(secretases, A42 generation, neuroinflammation, amyloid precipitation, and immunization), tau proteins (tau
phosphorylation/aggregation and immunotherapy), and amyloid deposition. Despite tremendous advancement
in our understanding of the underlying pathophysiology of Alzheimer's disease, the FDA (Food and Drug Administration)
only approved aducanumab for diagnosis and treatment in 2003. Hence, novel treatment tactics
are needed to find and develop therapeutic medicines to combat Alzheimer's disease.
3D Printable Drug Delivery Systems: Next-generation Healthcare Technology
and Regulatory Aspects
Authors: Saxena Anmol , Malviya Rishabha 
Published: November 2023

Abstract:
A revolutionary shift in healthcare has been sparked by the development of 3D printing, propelling
us into an era replete with boundless opportunities for personalized DDS (Drug Delivery Systems). Precise
control of the kinetics of drug release can be achieved through 3D printing, improving treatment efficacy and
patient compliance. Additionally, 3D printing facilitates the co-administration of multiple drugs, simplifying
treatment regimens. The technology offers rapid prototyping and manufacturing capabilities, reducing development
timelines and costs. The seamless integration of advanced algorithms and artificial neural networks (ANN)
augments the precision and efficacy of 3D printing, propelling us toward the forefront of personalized
medicine. This comprehensive review delves into the regulatory frontiers governing 3D printable drug delivery
systems, with an emphasis on adhering to rigorous safety protocols to ensure the well-being of patients by
leveraging the latest advancements in 3D printing technologies powered by artificial intelligence. The
paradigm promises superior therapeutic outcomes and optimized medication experiences and sets the stage for
an immersive future within the Metaverse, wherein healthcare seamlessly converges with virtual environments
to unlock unparalleled possibilities for personalized treatments.
Soluble Factors Associated with Denervation-induced Skeletal Muscle
Atrophy
Authors: Rodríguez Marianny Portal , Cabello-Verrugio Claudio 
Published: November 2023

Abstract:
Skeletal muscle tissue has the critical function of mechanical support protecting the
body. In addition, its functions are strongly influenced by the balanced synthesis and degradation
processes of structural and regulatory proteins. The inhibition of protein synthesis and/or the activation
of catabolism generally determines a pathological state or condition called muscle atrophy,
a reduction in muscle mass that results in partial or total loss of function. It has been established
that many pathophysiological conditions can cause a decrease in muscle mass. Skeletal muscle innervation
involves stable and functional neural interactions with muscles via neuromuscular junctions
and is essential for maintaining normal muscle structure and function. Loss of motor innervation
induces rapid skeletal muscle fiber degeneration with activation of atrophy-related signaling
and subsequent disassembly of sarcomeres, altering normal muscle function. After denervation, an
inflammation stage is characterized by the increased expression of pro-inflammatory cytokines
that determine muscle atrophy. In this review, we highlighted the impact of some soluble factors
on the development of muscle atrophy by denervation.
Short-term Administration of Naringin Improves Renal Function in Renal Ischemia-reperfusion by Increasing Aquaporin-1 and Aquaporin-2 Levels
Authors: Demir Zubeyde , Acar Gozde , Dasdelen Dervis , Mogulkoc Rasim , Baltaci Abdulkerim Kasim 
Published: November 2023

Background:
Since renal ischemia-reperfusion (I/R) can lead to a serious health problem,
aquaporins have important roles in preventing negative changes in electrolyte-water balance. This
study aimed to determine the effect of naringin treatment on renal function and AQP1 and AQP2
levels in the kidney cortex and medulla tissues in experimental renal I/R in rats.

Materials and Methods:
The study was carried out on 40 male Wistar-type rats, 8-12 weeks old. Experimental
groups were formed as follows: 1) Control, 2) Sham+vehicle, 3) Renal (I/R)+vehicle, 4)
Renal I/R+ Naringin (50mg/kg/day) (3 days of administration), and 5) Renal I/R+ Naringin(
100mg/kg/day) (3 days supplementation) group. First, the left kidney was removed by nephrectomy
under general anesthesia, and then the right kidney was subjected to 45 minutes of ischemia
and then 72 hours of reperfusion. Naringin was given to the experimental animals by an intraperitoneal
route at the beginning of the reperfusion, after 24 and 48 hours. At the end of the experiments,
first of all, blood samples were taken from the heart in animals under general anesthesia, and then the
animals were killed by cervical dislocation, and kidney tissue samples were taken. Osmolarity in
plasma and urine and plasma creatinine levels were evaluated. AQP1 and AQP2 levels were analyzed
in the kidney cortex and medulla tissues by ELISA and PCR methods.

Results:
In kidney tissues, I/R led to a decrease in plasma and urinary osmolality, AQP1 and AQP2
levels in the cortex and medulla, and an increase in urea and creatinine levels (p < 0.001). However,
naringin supplementation corrected the deterioration to a certain extent.

Conclusion:
The results of the study show that naringin supplementation at different doses, such as
50 or 100 mg/kg, may have protective effects on the deterioration of renal function caused by unilateral
nephrectomy and I/R in rats.
A Review of the Occurrence of Rheumatoid Arthritis and Potential
Treatments through Medicinal Plants from an Indian Perspective
Authors: Shekh Mohammad Raeesh , Ahmed Nasir , Kumar Vivek 
Published: November 2023

Abstract:
Arthritis is a medical condition that affects the joints and causes inflammation, pain,
and stiffness. There are different types of arthritis, and it can affect people of all ages, even infants
and the elderly. Recent studies have found that individuals with diabetes, heart disease, and
obesity are more likely to experience arthritis symptoms. According to the World Health Organization,
over 21% of people worldwide suffer from musculoskeletal problems. Roughly 42.19 million
individuals in India, constituting around 0.31% of the populace, have been documented as
having Rheumatic Arthritis (RA).

:
Compared to other common diseases like diabetes, cancer, and AIDS, arthritis is more prevalent
in the general population. Unfortunately, there is no specific cure for arthritis, and treatment plans
usually involve non-pharmacological methods, surgeries, and medications that target specific
symptoms. Plant-based remedies have also been shown to be effective in managing inflammation
and related complications. In addition to therapies, maintaining a healthy diet, exercise, and
weight management are essential for managing arthritis.

:
This review discusses the causes, prevalence, diagnostic methods, current and prospective future
treatments, and potential medicinal plants that may act as anti-inflammatory or anti-rheumatic
agents. However, more research is necessary to identify the underlying mechanisms and active
molecules that could improve arthritis treatment.
Dengue Fever Virus Envelope Glycoproteins Variability Characterized
Bioinformatically
Authors: Polanco Carlos , Uversky Vladimir N. , Huberman Alberto , Hernandez-Lemus Enrique , Rios Castro Martha , López Oliva Erika Jeannette , Martínez-Garcia Mireya , Buhse Thomas , Roldan Gomez Francisco J. , Vargas-Alarcon Gilberto , Zazueta Cecilia , Pimentel-Hernández Claudia 
Published: November 2023

Background:
The infection caused by the dengue fever virus is a severe threat to public
health on a global scale; nevertheless, there is currently no effective medical treatment or vaccine
available to prevent or treat the condition.

Objective:
To better understand the physicochemical regularities of these proteins, it is necessary to
carry out a computational multiparametric study of the amino acid sequences of envelope proteins
expressed by the dengue fever virus and obtain a bioinformatics method that can use the subsequences
of the training protein group to figure out the preponderant function of a protein, up to its
sequence.

Methods:
Essentially, at the amino acid level, various computational programs were applied to the
sequences expressing the dengue virus envelope glycoproteins to determine the PIM 2.0 v profile
and the Protein Intrinsic Disorder Predisposition (PIDP) profile of each protein, and then, at the nucleotide
level, a set of programs for genomic analysis was applied. Finally, these results were contrasted
with statistical tests.

Results:
The re-creation of structural morphological similarities provided by specific regularities in the
PIM 2.0 v profile and PIDP of the proteins from diverse dengue fever virus envelopes made it possible
to propose a computer method that employs the PIM 2.0 v profile to identify this group of proteins
based on their sequences; based on our findings, this method is a "fingerprint" of this protein group.

Conclusions:
The typical PIM 2.0 v profiles of the dengue fever virus proteins might be reproduced
by computational tools. This knowledge will be helpful in gaining a better understanding of the newly
discovered virus. Moreover, the method introduced here can identify, from the sequence, the
predominant function of the protein.