bluuebunny/crossref_metadata_2025_split huggingface dataset:
Morphofunctional changes in the immune system in colitis-associated colorectal cancer in tolerant and susceptible to hypoxia mice
Authors: Dzhalilova Dzhuliia , Silina Maria , Kosyreva Anna , Fokichev Nikolai , Makarova Olga 
Published: February 2025

Background
One of the effective strategies for the treatment of tumor diseases, including colitis-associated colorectal cancer (CAC), is immunotherapy. During inflammation, NF-κB is activated, which is connected with the hypoxia-inducible factor—HIF, regulating the immune cells functioning and influences the CAC development. Organisms differ according to their hypoxia resistance and HIF expression. Therefore, the aim of the study was to characterize the thymus, spleen and mesenteric lymph nodes morphofunctional features, as well as changes in the subpopulation composition of peripheral blood cells and mesenteric lymph nodes in tolerant and susceptible to hypoxia C57Bl/6 mice in CAC.

Methods
Hypoxia tolerance was assessed by gasping time measurement in hypobaric decompression chamber. Based on the outcome, the mice were assigned to three groups characterized as ‘tolerant to hypoxia’, ‘normal’, and ‘susceptible to hypoxia’. A month after determining hypoxia resistance CAC was modeled by intraperitoneal azoxymethane (AOM) administration and three cycles of dextran sulfate sodium consumption. Mice were sacrificed on the 141st day after the AOM administration, a morphological, morphometric and immunohistochemical study of tumors, morphological and morphometric study of thymus and spleen, and subpopulation composition of peripheral blood cells and mesenteric lymph nodes assessment were carried out.

Results
Tumors in tolerant and susceptible to hypoxia mice were represented by glandular intraepithelial neoplasia and adenocarcinomas, the area of which was larger in susceptible mice. Immunohistochemical study revealed a more pronounced Ki-67+ staining in tumors of susceptible mice. In CAC, only in tolerant mice, expansion of the thymic cortex was observed relative to the control group, while in susceptible ones, no changes were detected. Only in susceptible to hypoxia mice, spleen germinal centers of lymphoid follicles enlargement were observed. Only in susceptible mice during CAC, in comparison to the control group, the relative and absolute number of B-lymphocytes and relative—cytotoxic T-lymphocytes in blood increased. The relative cytotoxic T-lymphocytes and NK cells number in peripheral blood during CAC was higher in susceptible to hypoxia mice compared to tolerant ones. In susceptible to hypoxia mice, more pronounced changes in the mesenteric lymph nodes subpopulation composition of cells were revealed—only in them the absolute and relative number of B-lymphocytes and NK cells, the absolute number of cytotoxic T-lymphocytes increased, and the relative number of macrophages decreased.

Conclusions
Morphofunctional differences in the thymus, spleen, mesenteric lymph nodes and blood immune cells reactions indicated the more pronounced immune response to the CAC development in susceptible to hypoxia mice, which should be taken into account in experimental studies.
Assessment of the potential of drug-drug interactions among population-based oldest-old people in Turkiye
Authors: Özaydın Fuat Nihat , Özaydın Ayşe Nilüfer 
Published: February 2025

Background
The risk of potential drug‒drug interactions is highest in oldest-old people. Thus, the aim of this study was to investigate the frequency and type of potential drug‒drug interactions in population-based oldest-old people.

Methods
The type of study was descriptive. Ethical permission was obtained (13.04.2022/153). All participants were informed, and their written consent was obtained. The “oldest-old” were defined as those who were ≥85 years of age during the study period and living in Turkiye. These people were reached from every region of Turkiye via the snowball method and were visited at their homes. Data were collected via face-to-face interviews. Age, sex, city of residence, and generic names of regularly used medications were recorded. The medications used were analyzed according to the Beers 2019® Criteria and UpToDate® Lexicomp® drug interaction guides. SPSS was used for statistical analysis, and p < 0.05 was considered statistically significant.

Results
Data were collected from the 549 oldest-old people throughout Turkiye. Among the participants, 61.2% (n = 336) were women. The median age of the women was 88.00 years (minimum = 85, maximum = 101), and the median age of the men was 88.00 years (minimum = 85, maximum = 102). The distributions of men and women in the different age groups were similar (p = 0.341). The distributions of men and women across regions were similar (p = 0.826), most of whom (n = 300, 54.6%) had ≥1 potential drug‒drug interaction, according to the UpToDate analysis. The median number of medications used continuously was 4.0 (minimum = 0, maximum = 19). The median number of potential drug‒drug interactions was 1.0 (minimum = 0, maximum = 21). As the number of medications used increased, the number of potential drug‒drug interactions also increased (r = 0.737; p = 0.001). The number of potential drug‒drug interactions decreased with increasing age (r = −0.104; p = 0.015). According to the Beers 2019® Criteria, potential drug‒drug interactions were detected in only eight patients. The concordance between the Beers 2019® Criteria and the UpToDate®Lexicomb® drug interaction data was poor compared with the number of potential drug‒drug interactions (kappa = 0.024, p < 0.001). Central nervous system medications are a common group that can cause potential drug‒drug interactions according to both guidelines. Moreover, potentially inappropriate medications defined by the Beers 2019® Criteria were the most common causes of potential drug‒drug interactions, according to UpToDate®Lexicomb® drug interactions. The frequency of potential drug‒drug interactions was found to be high in the population-based oldest-old people interviewed in Turkiye. It has been determined that the use of more than one guide in the evaluation of potential drug‒drug interactions is safer.
Designing Supported Nanoparticles via Synergistic Ex‐Solution and Phosphorization for Tailored Active Site Generation
Authors: Kim Jun Kyu , Kim Sangwoo , Kim Yong Beom , Koo Bonjae , Oh DongHwan , Kim Hyunseung , Kim Kyeounghak , Han Jeong Woo , Jung WooChul 
Published: January 2025

AbstractSupported nanoparticles incorporating catalytically attractive nonmetal elements have gained significant attention as a promising strategy for enhancing catalytic activity in various industrial applications. This study presents an innovative one‐pot synthesis method for fabricating hybrid catalysts, which simultaneously modifies surface properties through the precipitation of nanoparticles with the concurrent incorporation of nonmetal elements. The underlying concept is to synchronize the temperature required for particle formation with that of nonmetal incorporation by adjusting the oxygen chemical potential of the host oxide. As a case study, Ir‐ and Ru‐doped WO3 are selected as the starting material, with phosphorus (P) as the representative nonmetal for surface functionalization. Notably, the hybrid catalyst, composed of amorphous (Ir,Ru)Px particles dispersed on P‐rich WO2.9 sheets, is synthesized through a single heat treatment at 500 °C, avoiding undesirable sintering of the host material. When used as a hydrogen evolution catalyst, this material exhibits outstanding mass activity, durability, compared to state‐of‐the‐art Pt/C catalysts. Density functional theory calculations further reveal that the superior performance of the hybrid catalysts attributes to improved water dissociation and favorable adsorption and desorption of key reaction intermediates. This novel synthesis strategy offers considerable potential for advancing diverse areas of heterogeneous catalysis.
Simultaneous Isotropic Omnidirectional Hypersensitive Strain Sensing and Deep Learning‐Assisted Direction Recognition in a Biomimetic Stretchable Device
Authors: Xu Muzi , Zhang Jiaqi , Dong Chaoqun , Tang Chenyu , Hu Fangxin , Malliaras George G. , Occhipinti Luigi G. 
Published: January 2025

AbstractOmnidirectional strain sensing and direction recognition ability are features of the human tactile sense, essential to address the intricate and dynamic requirements of real‐world applications. Most of the current strain sensors work by converting uniaxial strain into electrical signals, which restricts their use in environments with multiaxial strain. Here, the first device with simultaneous isotropic omnidirectional hypersensitive strain sensing and direction recognition (IOHSDR) capabilities is introduced. By mimicking the human fingers from three dimensions, the IOHSDR device realizes a novel heterogeneous substrate that incorporates the involute of a circle, resulting in isotropic behavior in the radial direction and anisotropic property in the involute direction for hypersensitive strain sensing. With the assistance of a deep learning‐based model, the IOHSDR device accomplishes an impressive accuracy of 99.58% in recognizing 360° stretching directions. Additionally, it exhibits superior performance in the typical properties of stretchable strain sensors, with a gauge factor of 634.12, an ultralow detection limit of 0.01%, and outstanding durability exceeding 15 000 cycles. The demonstration of radial artery pulse and throat vibration applications highlights the IOHSDR's unique characteristics of isotropic omnidirectional sensing and precise direction detection unleashing new classes of wearable health monitoring devices.
Taming Cr(VI) Toxicity in Telescoping Quinoxaline Synthesis
Authors: Nayek Pravat , Pal Buddhadeb , Mandal Tathagata , Mal Prasenjit 
Published: January 2025

AbstractWe introduce a method to transform toxic hexavalent chromium (Cr(VI)) into bio‐compatible trivalent chromium (Cr(III)) during quinoxaline synthesis from alkynes or alkenes. Using H5IO6 as a co‐oxidant, this process addresses environmental and safety concerns associated with Cr(VI). The telescoping synthesis involves the rapid formation of 1,2‐diketones from internal alkynes or alkenes using catalytic CrO3 and H5IO6 in acetonitrile at room temperature. Adding o‐aryl diamine in isopropanol completes the reaction, with the solvent quenching the chromium oxidation state and aiding quinoxaline formation. This method yields high efficiency, broad substrate scope, and excellent selectivity, offering an eco‐friendly pathway for quinoxaline production while reducing Cr(VI) toxicity.
Light‐Driven Carbon Fixation Using Photosynthetic Organelles in Artificial Photosynthetic Cells
Authors: Wang Weichen , Zhao Jingjing , Yang Boyu , Li Chao , Ren Yongshuo , Li Shubin , Zhang Xiangxiang , Han Xiaojun 
Published: January 2025

AbstractBuilding an artificial photosynthetic cell from scratch helps to understand the working mechanisms of chloroplasts. It is a challenge to achieve carbon fixation triggered by photosynthetic organelles in an artificial cell. ATP synthase and photosystem II (PSII) are purified and reconstituted onto the phospholipid membrane to fabricate photosynthetic organelles. With the integration of phycocyanin, the ATP production yield increases by 2.51‐fold due to the enhanced light harvesting capability. The carbon fixation pathway is established by converting α‐oxoglutarate to acetyl‐CoA and oxaloacetate with cascade enzyme reactions including the isocitrate dehydrogenase (IDH), aconitase (ACO), and ATP citrate lyase (ACL). The photosynthetic organelles, phycocyanin, and carbon fixation pathway are encapsulated into giant unilamellar vesicles to obtain artificial photosynthetic cells, which convert α‐oxoglutarate to acetyl‐CoA and oxaloacetate inside artificial cells upon light irradiation. The acetyl‐CoA is the most important intermediate product in the cellular metabolic networks for the synthesis of cholesterol and fatty acids. Our results provide a way for efficient light energy conversion to produce ATP and fix CO2, and pave the path to build autonomous artificial cells with more complicated metabolic networks.
Platinum‐Nickel Oxide Cluster‐Cluster Heterostructure Enabling Fast Hydrogen Evolution for Anion Exchange Membrane Water Electrolyzers
Authors: Zheng Xinying , Zheng Xiaozhong , Gao Mingxia , Liu Yongfeng , Pan Hongge , Sun Wenping 
Published: January 2025

AbstractCarbon black has been extensively employed as the support for noble metal catalysts for electrocatalysis applications. However, the nearly catalytic inertness and weak interaction with metal species of carbon black are two major obstacles that hinder the further improvement of the catalytic performance. Herein, we report a surface functionalization strategy by decorating transition metal oxide clusters on the commercial carbon black to offer specific catalytic activity and enhanced interaction with metal species. In the case of NiOx cluster‐decorated carbon black, a strongly coupled cluster‐cluster heterostructure consisting of Pt clusters and NiOx clusters (Pt−NiOx/C) is formed and delivers greatly enhanced alkaline hydrogen evolution kinetics. The NiOx clusters can not only accelerate the hydrogen evolution process as the co‐catalyst, but also optimize the adsorption of H intermediates on Pt and stabilize the Pt clusters. Notably, the anion exchange membrane water electrolyzer with Pt−NiOx/C as the cathode catalyst (with a loading of only 50 μgPt cm−2) delivers the most competitive electrochemical performance reported to date, requiring only 1.90 V to reach a current density of 2 A cm−2. The results demonstrate the significance of surface functionalization of carbonaceous supports toward the development of advanced electrocatalysts.
A High‐Capacity Manganese‐Metal Battery with Dual‐Storage Mechanism
Authors: Shen Dongyang , Zhao Guili , Jiang Taoli , Liu Hongxu , Luo Ruihao , Zhang Zuodong , Zhang Ziwei , Chen Jinghao , Xu Jingwen , Feng Yuancheng , Tong Peiyan , Tan Shunxin , Wang Yidi , Lv Zhenshan , Li Xiangyang , Chen Wei 
Published: January 2025

AbstractAs a promising post lithium‐ion‐battery candidate, manganese metal battery (MMB) is receiving growing research interests because of its high volumetric capacity, low cost, high safety and high energy‐to‐price ratio. However, the low energy density, mainly constrained by scarce choices and unsatisfying capacity of cathodes, strictly bottlenecks the development of MMBs. In this work, a new class of cathodes based on novel dual‐storage mechanism (DSM) are reported. Working principles of DSM are revealed and deeply understood via ex situ X‐ray diffraction and X‐ray photoelectron spectroscopy. Besides, a proof‐of‐concept DSM‐based Cu1.8S cathode, which shows the highest specific capacity of 220 mAh g−1 and 97.1 % higher energy density than previously reported cathodes in storing Mn2+ ions, is presented. The key determinants on DSM and design strategies for next‐generation cathodes are revealed via theoretical calculations. This work provides a new class of high‐capacity cathode materials for MMBs, which is expected to draw inspirations to further enhance the energy density of MMBs.
Flow Electroreductive Nickel‐Catalyzed Cyclopropanation of Alkenes Using gem‐Dichloroalkanes
Authors: Regnier Morgan , Vega Clara , Ioannou Dimitris I. , Zhang Zhenyu , Noël Timothy 
Published: January 2025

AbstractCyclopropanes are valuable motifs in organic synthesis, widely featured in pharmaceuticals and functional materials. Herein, we report an efficient electrochemical methodology for the cyclopropanation of alkenes, leveraging a nickel‐catalyzed process in continuous‐flow. The developed protocol demonstrates broad substrate scope, accommodating both electron‐rich and electron‐poor alkenes with high functional group tolerance. Beyond dichloromethane as a feedstock methylene source, the methodology enables the synthesis of methylated, deuterated, and chloro‐substituted cyclopropanes. Mechanistic investigations suggest the electro‐generation of a nickel carbene as key intermediate. Notably, the reaction operates under ambient conditions, tolerates air and moisture, and achieves scalability through continuous‐flow technology, offering a straightforward route to multi‐gram quantities with enhanced throughput.
Chemically Patterning Lithiophilic Interphase to Harmonize Spatial Electrons and Thermal Catalysis Dynamics for Safe Lithium Metal Batteries
Authors: Wang Yisha , Xu Feng , Ang Edison Huixiang , Yang Liu , Cui Tianyang , Sun Haoteng , Zhang Mingtong , Yang Tianxiang , Zhang Hanqi , Zhu Jixin , Hu Yuan 
Published: January 2025

AbstractLithium metal batteries have garnered significant attention as promising energy storage solutions. However, their performance is often compromised by the risks associated with highly active metallic lithium, unrestricted electrode expansion, and excessive dendrites growth. Here we introduce an advanced lithiophilic anode substrate designed by chemically patterning technology for multiple security enhancements. The innovative lithiophilic array harmonizes spatial Li+ to prepare compact and reversible electrodes. The composite electrodes feature an enhanced C−F component in the solid‐electrolyte interface, which protects the deposited lithium metal from unwanted side reactions, thereby stabilizing electrochemical cycling. Notably, the thermal safety can be revealed through the substrate‘s excellent catalytic ability to convert smoke and toxic gases during extreme thermal runaway. This work demonstrates a novel approach to integrating battery cycling stability with thermal safety, paving the way for more reliable and secure energy storage systems.
Synergizing Interfacial Electric Field Regulation and In situ Robust Interphases for Stable Lithium Metal Batteries at High Currents
Authors: Xie Weixiang , Wu Junxiong , Li Xiaoyan , Song Zhengguang , Tong Lijuan , Miao Yuhui , Li Manxian , Li Xuan , Wang Manxi , Chen Yue , Chen Xiaochuan , Chen Yuming 
Published: January 2025

AbstractEfficient cycling of lithium (Li) metal batteries (LMBs) under extremely high current conditions is critical for their practical applications. Here, we report a novel additive containing fluorine, nitrogen, and iodine elements (designated as FCS) to stabilize Li metal anodes in glyme‐based ether electrolytes under high current conditions. Experimental results and molecular dynamics (MD) simulations demonstrate that the cation of FCS selectively adsorbs on the electrode surface, optimizing the inner Helmholtz plane (IHP) structure and effectively regulating the surface electric field, thereby promoting homogeneous Li deposition. Simultaneously, the preferential decomposition of the FCS produces a mechanically robust and ionically conductive solid electrolyte interphase (SEI) comprising LiF, Li3N, and LiI components. Consequently, with the FCS additive, Li||Cu cells demonstrate a remarkably average Coulombic efficiency (CE) of 98.12 % at an extremely high current of 20 mA cm−2 over 400 cycles. Additionally, Li||SPAN cells maintain a reversible capacity of 1126 mAh g−1 at 0.5 A g−1 after 200 cycles. This work presents a new approach to simultaneously tune the Helmholtz plane and SEI using trace amounts of additive, paving the way for stable and efficient LMBs under high‐current conditions.
On‐Demand Nitric Oxide Generation via Thermal Decomposition of N‐Trityl Dihydro‐1,2‐Oxazines
Authors: Li Shuxiao , Blackburn Nathan W. , Ward Cassandra L. , Dent Matthew R. , Bour James R. 
Published: January 2025

AbstractInhaled nitric oxide (iNO) is a promising therapy for a variety of pulmonary conditions but is limited by the cost, portability, and safety limitations of the compressed gas cylinders used in conventional iNO delivery systems. On‐demand generation of iNO via thermally controlled decomposition of an NO‐genic precursor is an attractive alternative to systems based on compressed gas cylinders. However, most NO‐releasing materials, which would form the basis of such a system, are designed for in vivo applications, but not for gas flow release at elevated temperatures. Novel NO donors with tunable kinetics suited for simple thermal generation are needed to realize such iNO delivery systems. Here we report the development of a new class of NO donors based on N‐trityl 3,6‐dihydro‐1,2‐oxazines. We show that amorphous solid dispersions of these molecules in porous polymers exhibit consistent, thermoresponsive NO release in good yields when heated above 90 °C in the presence of a carrier gas. We further demonstrate that these donors undergo NO release in aqueous media at 37 °C. Collectively, this work adds a new class of NO donor to the basis set of known NO‐genic molecules and establishes a potential chemical basis for a low‐power, small‐footprint iNO delivery system.
Efficient Synthesis of Dihydropyrimidinones Using Advanced Ni (II)‐Doped Zn‐BDC Microcrystals: A Breakthrough in Catalytic Performance, Reusability, and Structural Integrity
Authors: Aziz Dara Muhammed , Othman Othman Salih 
Published: January 2025

ABSTRACTNickel (II) ions (Ni (II)) doped into the zinc‐based metal–organic framework Zn‐BDC have shown exceptional catalytic activity as heterogeneous catalysts for the three‐component Biginelli condensation reaction, delivering yields ranging from 62% to 96% with excellent selectivity under diverse reaction conditions. The Ni doping was achieved through a facile solvothermal synthesis, producing Ni(x)‐Zn‐BDC catalysts, where x represents the weight percentage of Ni relative to Zn (e.g., Ni[10]‐Zn‐BDC). Comprehensive characterization of the synthesized catalysts was conducted using advanced spectroscopic and analytical techniques, confirming successful incorporation of Ni into the Zn‐BDC framework without compromising its structural integrity. The Ni(10)‐Zn‐BDC catalyst, in particular, exhibited remarkable efficiency in facilitating the reaction under mild conditions. Furthermore, the catalyst demonstrated excellent recyclability and stability, maintaining consistent catalytic performance over multiple cycles. These findings highlight Ni(x)‐Zn‐BDC as a promising and sustainable material for the synthesis of dihydropyrimidinones, underscoring its potential in green and efficient catalytic processes.
Aggregation‐induced Electrochemiluminescence of AgNCs Enhanced with AuNPs@MXene Composites for Ultrasensitive Detection of microRNA
Authors: Zhou Xiaoqian , Song Haicheng , Zhang Xinying , Chen Lifei , Chen Yingying , Li Zhenzhen , Feng Lingyan 
Published: January 2025

AbstractMXene, a two‐dimensional nanomaterial, has metal conductivity, high electronegativity, functionalized with surface groups, which make it widely applicable in catalysis and biosensing. However, studies on the principle of enhanced electrochemiluminescence (ECL) by MXene composites and the improvement of their performance in catalyzing the ECL reaction are still in their infancy. In this study, gold nanoparticles (AuNPs) are obtained by mild reductive reduction and loaded in situ on the Ti3C2Tx MXene surface to form the composites (AuNPs@MXene). In oxygenated PBS test buffer, AuNPs@MXene enhance the ECL emission of silver nanoclusters (AgNCs) with aggregation‐induced electrochemiluminescence (AIECL) properties as luminophore. Approximately 7.5‐fold enhancement of ECL signals is obtained by using two ECL enhancement strategies: an efficient AIECL emitter and a co‐reaction accelerator. The special nucleic acid structure with “Three Way Junction (TWJ)” enables an ultra‐sensitive detection of microRNA, providing an efficient and ultra‐sensitive method for microRNA detection. The biosensor achieves a wide detection range of microRNA‐21 from 100 aM to 1 nM, with a low detection limit of 31 aM, and exhibits excellent stability, selectivity and high reproducibility in real samples.