bluuebunny/crossref_metadata_2025_split huggingface dataset:
Parents Awareness about the Use of Self-Medication in Children, Saudi Arabia, 2023
Authors: Shammari Reham Obaid AL , Enizy Rasha Jazy AL 
Published: January 2024

Abstract
Aim: To assess the knowledge and practice of parents about the use of self-medication in their children and to determine the reasons that lead to this situation. In addition to determining the relationship between self-medication practice and socio-demographic characteristics. An observational cross-sectional intuitional-based study including 427 parents regarding children's self-medication was conducted in King Saud Hospital in Qassim region of Saudi Arabia.
Result: A total of 427 participants were included in this study; (62.1%) of them were females, and (37.9%) were males. The commonest age group was found to be 31–35 years old (25.1%). Most of the participants (72.8%) were graduates, while (7.5%) were postgraduates. Most of the participants (78.7%) predominantly used synthetic medicines, while (21.3%) used herbal medication. The majority of the parents (69.8%) were aware of the side effects and complications of the medications. The most frequent self-medications used by the parents were antipyretics (81.5%), cough syrups (41.9%), and anti-allergy medication (23%). Moreover, reasons for parental self-medication of their children were awareness about their children’s disease from the symptoms (72.6%), waiting time at the clinic for too long (61.8%), and consultation fees being too expensive (52%). Among the socio-demographic characteristics that we included in the table, only occupation and the number of children were found to be statistically significant (p≤0.05).
Conclusion: Overall, this study can conclude that there is a huge use of self-medication for children by parents attending King Saud Hospital, Qassim region, Saudi Arabia. The knowledge and practice of the majority of parents regarding self-medication in their children were found to be acceptable. However, despite that, many of the parents were educated, but their knowledge of many of them about self-medication was insufficient. Significant associations were found between the use of self-medication and both occupation and the number of children.
Sociological Analysis of Stress Management among Farmers and Rural Development In Selected Communities in Kwara State
Authors: Folorunsho Sunkanmi 
Published: January 2024

Abstract

Rural farmers, in most cases, act as their own managers and feel responsible for numerous farming issues over which they have little or no control. Essentially, farmers allocate a significant portion of their available time primarily to safety, as well as improvements in crops, land, and even livestock. However, it is very regrettable to think that they do not extend the same care or give equal consideration to their physical, social, and mental health and well-being, increasing the likelihood of stress. If this problem of stress persists, it could lead to a reduction in their ability to provide for themselves and also impact rural development. This is why the study was undertaken to determine whether there is a relationship between stress management among farmers and rural development. This was achieved through the use of the multi-stage sampling technique in choosing 360 respondents and employing Robert Karasek’s stress theory to explain the subject matter. The study concluded that stress among farmers could lead to rural underdevelopment. Thus, the study recommends that farmers should make an effort to reduce their stress by spending quality time with their families, employing more labor (if they can afford it), and interacting with other farmers, among other strategies.
Fighting back, moving forward: Refugee women's agency in stories of resistance and resilience
Authors: Borges Gabriela Mesquita 
Published: January 2024

Abstract

This article introduces a novel framework for understanding refugee agency, exemplified through the experiences of refugee women across three stages and (geographical and symbolic) places: in countries of asylum, in forced migration, and in asylum. Based on 24 in-depth, semi-structured interviews with refugee women residing in Portugal, the article challenges prevailing approaches that primarily focus on refugees' efforts to change their circumstances. Instead, it advocates for conceptualizing refugee women's agency as both an emancipatory resistance against oppressive structures (resistance) and an adaptive ability to act within these constraints (resilience). In understanding resistance, the article prompts researchers to investigate how refugee women actively confront and challenge oppressive structures, advocating for an emancipatory approach that goes beyond conventional analyses of refugees seeking to change their circumstances. Conversely, the adaptive dimension of agency, framed as resilience, invites scholars to explore the resourcefulness and creative strategies employed by refugee women within the confines of these oppressive structures. This enriched perspective not only contributes to academic discourse but also provides practical insights for policymakers and humanitarian practitioners aiming to better support and empower refugee women in their daily lives.
The Effect of Qigong Exercise on State Anxiety Levels of Inpatients in Psychiatric Wards: A Randomized Controlled Study
Authors: babaoglu elcin , yalcinturk aydan akkurt , gunes emel erdeniz , sipahi asli zeynep , dogan selma 
Published: January 2024

Abstract
Qigong, an ancient Chinese medical practice, is currently utilized as a complementary treatment for anxiety and depression. While existing literature has investigated the impact of Qigong exercises on trait anxiety in outpatients, there is limited research on its influence on state anxiety in inpatients. This study examines the effect of Qigong exercise on the state anxiety levels of inpatients in psychiatric wards. This study is a single-blind, randomized controlled trial. Patients were randomly assigned to either the intervention or control group. Anxiety levels were assessed using the STAI-I form before (test-1) and after (test-2) a 40-minute Qigong exercise in the intervention group. The control group completed the STAI-I forms without engaging in Qigong exercises. Seventy inpatients participated in the study, with 35 patients in each group. The mean post-test scores of the intervention group (27.20 ± 5.57) were significantly lower than those of the control group (39.72 ± 10.84). Additionally, a statistically significant difference was observed between the mean test-1 (38.42 ± 9.7) and test-2 scores (27.2 ± 5.57) within the intervention group. A daily 40-minute Qigong exercise can effectively reduce anxiety levels in psychiatry inpatients and reduce the risk of potential adverse outcomes associated with aggression and heightened anxiety. Implementing this approach as a patient contribution can improve the quality of care in psychiatric units while reducing the length of hospitalization and the need for polypharmacy.
A review on medicinal and ethnomedicinal uses, biological features, and phytochemical constituents of Sesbania sesban L. Merr., a nitrogen-fixing plant native to the Republic of Chad
Authors: Mahamat Ousman Brahim , Younes Saoud , Otchom Brahim Boy , Franzel Steven , Hidjazi Al-Djazouli Ouchar Mahamat , Soumaya El Ismaili 
Published: January 2024

Abstract
This study reports on a literature review of the leguminous tree Sesbania sesban (L.) Merr is found in the N'Djamena region, the Republic of Chad. The study focused on S. sesban’s medicinal and ethnomedicinal uses, biological features, and phytochemical constituents to assist in future evaluations. A literature review was conducted using academic websites, such as Science Direct and Springer, online international plant databases, and data from national herbaria. S. sesban is a perennial shrub or tree that measures 3–4 meters in height. This species is becoming rare in Ndjamena but can be found in the rainy season, while in winter, the species occurs mainly in ponds (called in the Chadian dialect "Bouta"), and in the shores of the Chari and Logone rivers. The local inhabitants in Chad use the species as medicine, livestock feed, fuelwood, and for improving soil fertility and repelling desert encroachment. Traditional healers use its leaves to treat breast cancer and edema. S. sesban is an essential species native to the Republic of Chad that needs conservation and valorization. Viewing its importance and rarity in N’Djamena, a strategy for replanting the species in gardens, homes, and fields around Ndjamena and other regions of Chad is recommended.
Role of E-cadherin and β-catenin in head and neck squamous cell carcinoma
Authors: Petrova A. A. , Samoylova S. I. , Magomedkerimova L. V. , Parts S. A. , Reshetov I. V. 
Published: January 2024

Aim of the study: to present and summarize current data on the prognostic value of E-cadherin and β-catenin markers for head and neck squamous cell carcinoma, as well as to substantiate the potential benefit from implementing research results into clinical practice within the framework of a personalized approach to the treatment of head and neck squamous cell carcinoma.Material and Methods. We performed a literature search and review in Pubmed, Scopus, Google Scholar and RSCI databases regarding the association of the level of E-cadherin and β-catenin markers with disease prognosis, aggressiveness of tumor behavior and response to treatment.Results. Detailed information on the functions and mechanisms of E-cadherin and β-catenin proteins were presented and pathogenetic pathways involved in epithelial-mesenchymal transition were described. The results of studies on the association of β-catenin and E-cadherin expression levels with the prognosis of head and neck squamous cell carcinoma are collected and summarized. High expression levels of β-catenin and E-cadherin are associated with lymph node metastasis, poor prognosis and poor response to treatment.Conclusion. The expression levels of β-catenin and E-cadherin correlate with tumor invasion and lymph node metastasis, thus suggesting that β-catenin and E-cadherin can be used as potential markers of prognosis and treatment response in patients with head and neck squamous cell carcinoma. Further studies are needed to evaluate the co-expression of E-cadherin, β-catenin and other squamous cell carcinoma-associated markers, their impact on prognosis and treatment response, as well as their prognostic value.
Impact of molecular genetic profle of meningiomas on the clinical course and recurrence using combined modality treatment
Authors: Sergeev G. S. , Gaytan A. S. , Travin M. A. , Ponomarev A. B. , Afonina M. A. , Savitskaya I. A. , Yakhya F. , Krivoshapkin A. L. 
Published: January 2024

Introduction. Meningioma is one of the most common central nervous system tumors, accounting for 39.7 % of all primary brain tumors. The tumor originates from arachnoid meningothelial cells and is characterized by a wide range of histological types classified into 15 subtypes. The histological classification of meningiomas allows us to predict meningioma behavior and the risk of disease recurrence, as well as to define treatment strategies. However, clinical outcomes in histological subgroups of patients are often inconsistent with the histological grade of malignancy. Thus, a more reliable method is needed both to determine the histological subtype of the tumor and to predict the clinical course of the disease with the potential for targeted treatment.The purpose of the study was to summarize the available data on the effect of results of the genomic and proteomic tumor analysis on carcinogenesis with the relationship between the mutational changes and noninvasive diagnosis, treatment and the course of the disease.Material and Methods. Literature search was carried out in the PubMed, Elibrary system, publications were included mainly from 2010 to 2023. with the identification of articles by the keyword “genetic analysis of meningiomas” and synonyms. 550 articles were found, of which 55 were used to write a literature review.Conclusion. The study of the molecular genetic profile of meningiomas will improve the classification and establish a correlation with MRI data, the course of the disease and prognosis.
Thyroid cаncer occuring during pregnаncy. Literаture review
Authors: Chernyаkov A. A. , Chizhevskаyа S. Y. , Choynzonov E. L. , Bаlаtskаyа L. N. , Spirinа L. V. , Chernyshovа A. L. , Mukhаmedov M. R. , Dil O. S. 
Published: January 2024

Introduction. Thyroid cаncer is the most common endocrine malignancies accounting for approximately 2 % of all cancers in Russiа аnd 2.3 % in the world. Several studies have reported on the infuence of hormonаl status on the prognosis of thyroid cаncer, in pаrticulаr, femаle sex hormones, such as estrogens аnd progesterone, contribute to thyroid cell proliferation. In this regard, thyroid cancer occurring during pregnancy is of particular interest.The purpose of the study was to аnаlyze the literаture sources concerning thyroid cаncer occurring during pregnаncy and to evaluate the impact of pregnаncy on the progression of thyroid cancer.Mаteriаl аnd Methods. A literature seаrch wаs conducted using Cochrаne, Librаry, and Elibrаry databases. The review included studies from 1981 to 2022.Conclusion. Currently, most studies report thаt pregnаncy does not adversely affect the outcomes of thyroid cancer; however, many aspects concerning the hormonаl effect аnd receptor stаtus of thyroid cancer require more detаiled study.
Relationship between the cytokine profle of supernatants of invasive breast carcinoma and its molecular and histopathological characteristics
Authors: Autenshlyus A. I. , Arkhipov S. A. , Mikhaylova E. S. , Arkhipova V. V. , Varaksin N. A. 
Published: January 2024

The aim of the study was to analyze the correlation between the cytokine profile of supernatants of invasive breast carcinoma of a nonspecific type (IBC-NST) samples, histopathological and molecular genetic parameters of IBC-NST, expression of the CD34 as a marker of angiogenesis and metastasis to regional lymph nodes (RLN).Material and Methods. The production of 14 cytokines in IBC-NST biopsy samples from 28 patients aged 37–60 years was studied. The concentration of cytokines in the supernatants of biopsies (CCSB) was determined (in pg/ml) using enzyme immunoassay (ELISA). The expression of CD34 and markers of IBC-NST molecular subtypes (HER2/neu, ER, PR, Ki67) in IBC-NST biopsy samples was evaluated by immunohistochemical method. The relative content of tumor cells of different differentiation grade in the IBC- NST samples was evaluated by histopathological analysis.Results. The assessment of CCSB showed statistically significant differences in IFN-γ, G-CSF, IL-2, IL-10 and MCP-1 between patients of group I (with metastases in RLNs) and group II (without metastases in RLNs). In group I, the correlations between histopathological parameters (Her2/neu, CD34 and Ki67 expressions, % of mitoses and poorly-differentiated cancer cells) and CCSB (MCP-1, IL-18) were revealed. In group II, the correlations between CCSB (IL-2, VEGF-A, G-CSF, IL-1Ra) and histopathological parameters, such as expression of Her2/neu, CD34, PR, % of mitoses and well-differentiated cancer cells, were revealed. The ROC analysis showed that the presence or absence of metastases in RLNs can be predicted on the basis of CD34 expression levels and concentrations of IL-10, G-CSF, and MCP-1 in supernatants of IBC-NST biopsy samples. The quality of the model for stratifying patients into groups with and without RLN metastases, based on the assessment of the concentration of MCP-1 in the supernatants of IBC-NST biopsies, reached maximum values (AUC=1.000) with relatively high CD34 expression.Conclusion. The analysis of the data obtained showed that the assessment of CD34 expression and production of cytokines in IBC-NST biopsies is important for predicting the presence or absence of metastases in RLNs.
THE QUALITY OF EARLY CHILDHOOD EDUCATION SERVICE IN INDONESIA
Authors: Sanny Lim 
Published: January 2024

Education is the most important thing as education is a strategic tool to improve the standard of human life. Parents play a very important role in choosing their children’s school. This research aims to find out the effect of quality of educational service and school reputation to parents’ satisfaction towards parents’ decision in choosing the school. Research is done in Indonesia, taking 400 random samples from Indonesia’s big cities. The result shows that parents’ decision in choosing a school is highly affected by the service quality of educational service and school reputation. As a result, the improvement of service quality for every school is required in order to make parents more satisfied and to gain a good reputation.
THE INFLUENCE OF SERVICE QUALITY, PERCEIVED VALUE AND CORPORATE IMAGE TOWARD INPATIENT SATISFACTION ON PRIVATE HOSPITAL
Authors: Novella Selly , Polla Johannes Ronaldy , Dharma Octa Marihot , Walia Puspa 
Published: January 2024

The purpose of this research was to determine the influence of service quality, perceived value, and corporate image of the hospital toward inpatient satisfaction of private hospitals in Jabodetabek. This study is categorized as a survey research, where researchers distributed questionnaires to 155 respondents who had been inpatients in private hospitals in Jabodetabek area. The method that used in this research is quantitative method and descriptive analysis. The method used in this research is simple and multiple linear regressions using SPSS v20. The results of this research showed that service quality, perceived value, and corporate image of Private Hospitals in Jabodetabek have significantly affect patient satisfaction on private hospitals in Jabodetabek.
Business Perspective in Integrating Agricultural Commodity Exchange and Warehouse Receipt System: A decade of Indonesia Experience
Authors: Sunarto Hari , Marwati Marwati , Hananto Hans , Yuliawati Yuliawati 
Published: January 2024

This exploratory research on the integration process of Agricultural Commodity Exchange (ACE) and Warehouse Receipt System (WRS) which has been launched since 2008 in Indonesia is based on a business perspective. The study is part of a comprehensive research that has been started in 2008 and is expected to continue until 2019. Data are obtained through observation, interviews with key informants implementing government policies, several WRS warehouse managers and ACE, secondary data and surveys to farmers. ACE is meant to increase famers bargaining power and WRS is to increase the price of agricultural commodities as well as part of the national logistics system that supports national food security policies. The efforts of CoFTRA to develop and integrate between ACE and WRS were never stopped since they were introduced in 2008, in fact until now they have not been well integrated. From a business perspective, so far there has not been a choice of sustainable business models for ACE and WRS as business start-ups that benefit all stakeholders, assuming without the support of government subsidies.
Circ_0079471 Regulates the Proliferation, Migration, Invasion and Apoptosis of Osteosarcoma Cells by Mediating miR-485-3p and TRIP6
Authors: Liu Wei , Li Qingning , Zhu Nan , Zhang Shuo , Jing Juehua , Zhan Junfeng 
Published: January 2024

Background:
Circular RNAs (circRNAs) are a special class of non-coding
RNA molecules that show a closed circular structure and have been implicated in both
tumour formation and oncogenesis.

Objective:
This study aimed to learn more about how circ_0079471 functions in osteosarcomas
(OSs).

Methods:
Quantitative real-time polymerase chain reaction was used to detect the expression
levels of thyroid hormone receptor-interacting protein 6 (TRIP6), miR-485-3p
and circ_0079471. Methyl-thiazolyl-tetrazolium and flow cytometry were used to track
cell growth and cell-cycle progression, and the research explored wound healing (migration)
and invasion using Transwell plates. Western blotting was used to determine the
protein expression of TRIP6, proliferating cell nuclear antigen and cyclin D1, and a dual-
luciferase assay revealed the target relationship.

Results:
A xenograft experiment evaluated the in vivo effects of circ_0079471 on OS,
and the results revealed the high expression of circ_0079471 in OS tissue and cells. The
proliferation, cell-cycle migration and invasion of cells were reduced after circ_0079471
knockdown in OS cells; however, the effects of this knockdown were reversed when
TRIP6 was overexpressed in the OS cells. The function of circ_0079471 was also
achieved by in vivo miR-485-3p sponging. The upregulation of miR-485-3p and the
downregulation of TRIP6 partly resulted in circ_0079471 downregulation, which subsequently
inhibited OS progression.

Conclusion:
According to these results, circ_0079471 influences the development of
OS by regulating miR-485-3p and TRIP6.
Fusobacterium/Peptostreptococcus - A Case Report of Community-
Acquired Empyema Resulting in Surgical Decortication with Prolonged
Antibiotic Therapy: A Case Series and Review of the Literature
Authors: Emmanuel Garrastegui-Mercado , Chady Awad , Antony Suresh 
Published: January 2024

Background:
Infections caused by anaerobic bacteria occur frequently and can be serious
and life-threatening. Anaerobes are a rare cause of community-acquired pneumonia with Streptococcus
pneumonia and respiratory viruses being the most frequently detected pathogens. We, herein,
report a case of Fusobacterium/Peptostreptococcus parapneumonic effusion with empyema in a patient
without risk factors for aspiration pneumonia. This case presents an opportunity to discuss an
unusual case of community-acquired empyema secondary to anaerobic infection in a patient without
the common risk factors for aspiration.

Case Presentation:
A 59-year-old male patient without significant past medical history apart from a
twenty-five-year history of smoking presented due to left flank pain and shortness of breath. Findings
of a complicated parapneumonic effusion were found on imaging, resulting in surgical decortication
and prolonged antibiotic therapy.

Discussion:
Parapneumonic effusions and empyema are relatively common complications of pneumonia.
It is important to note that the incidence of anaerobic empyema has been on the rise due to
more modern culturing techniques.

Conclusion:
This case highlights an unusual presentation of community-acquired empyema secondary
to anaerobes without any risk factors for aspiration pneumonia. Therefore, clinicians should consider
the possibility of anaerobic coverage in the treatment of community-acquired empyema in the
appropriate setting.