bluuebunny/crossref_metadata_2025_split huggingface dataset:
Cyclohexene oxide CA, a derivative of zeylenone, exhibits anti-cancer activity in glioblastoma by inducing G0/G1 phase arrest through interference with EZH2
Authors: Su Rui , Cao Weiwei , Ma Guoxu , Li Weiping , Li Zongyang , Liu Yongpei , Chen Lei , Chen Zebin , Li Xuejuan , Cui Ping , Huang Guodong 
Published: January 2024

Introduction: Due to its highly aggressiveness and malignancy, glioblastoma (GBM) urgently requires a safe and effective treatment strategy. Zeylenone, a natural polyoxygenated cyclohexenes compound isolated from Uvaria grandiflora, has exhibited potential biological activities in various human diseases, including tumors.Methods: We designed and synthesized a series of (+)-Zeylenone analogues and evaluated their anti-GBM roles through structural-activity analysis. Cell Counting Kit-8, TUNEL, transwell and flow cytometry were employed for investigating the anticancer effects of CA on GBM cells. Western blotting, molecular docking, qRT-PCR and ChIP assays were performed to reveal the underlying mechanisms by which CA regulates the GBM cell cycle. The nude mouse xenograft model, HE staining, immunohistochemistry and was used to evaluate the anticancer effect of CA in vivo.Results: We identified CA ((1R, 2R, 3S)-3-p-fluorobenzoyl-zeylenone) as having the lowest IC50 value in GBM cells. CA treatment significantly inhibited the malignant behaviors of GBM cells and induced G0/G1 phase arrest in vitro. Furthermore, we validated the molecular mechanism by which CA interferes with EZH2, attenuating the down-regulation of cyclin-dependent kinase inhibitors p27 and p16 by the PRC2 complex. By establishing orthotopic nude mice models, we further validated the inhibitory role of CA on tumorigenesis of GBM cells in vivo and its potential values to synergistically potentiate the anti-tumor effects of EZH2 inhibitors.Conclusion: Overall, this paper elucidated the anti-GBM effects and potential mechanisms of CA, and may provide a therapeutic drug candidate for GBM treatment.
Spanish validation of the simple lifestyle indicator questionnaire: validity and reliability analysis
Authors: Montero-Sandiego Elisabet , Ruiz-Robledillo Nicolás , Ferrer-Cascales Rosario , Clement-Carbonell Violeta , Alcocer-Bruno Cristian , Albaladejo-Blázquez Natalia 
Published: January 2024

IntroductionIt has been shown that lifestyle is a highly modifiable determinant having a direct effect on the health status. Therefore, short and simple questionnaires assessing the lifestyle of the general and clinical population are needed to create interventions on behavioral aspects that can improve the health status. The Simple Lifestyle Indicator Questionnaire (SLIQ) is a validated health scale in English that combines five lifestyle factors: diet, exercise, alcohol consumption, tobacco use, and stress level. The objective of this study was to validate the SLIQ questionnaire in Spanish by analyzing the scale’s validity and reliability. Its discriminatory power of the scale was also examined by evaluating the differences in health outcomes according to the levels of adherence to a healthy lifestyle.MethodsThe sample consisted of 745 participants with an average age of 39.94 (SD: 16.99). A transcultural adaptation process was carried out to validate the SLIQ questionnaire in the Spanish context, to determinate the structural equivalence of the Spanish version as compared to the English version, and to assess the psychometric properties of the scale. PREDIMED and IPAQ scales were used to analyze the convergent validity of the Spanish version of the SLIQ regarding to diet and exercise, and the questionnaires SF-12 and DASS-21 questionnaires were used to assess the capacity of the Spanish version of the SLIQ to discriminate health status related to different levels of reported lifestyles.ResultsRegarding validity, the results indicate significant correlations between the different dimensions of the SLIQ questionnaire and those used as a reference. As for reliability, the test–retest analyses reveal a high temporal consistency for the scores obtained on the questionnaire. Finally, the differences found in anxiety, depression, and quality of life, with regard to the different levels of adherence in the SLIQ questionnaire, suggest that the questionnaire’s Spanish version has adequate discriminatory power.DiscussionThe obtained correlation coefficients between the SLIQ and the other standardized measures pointed out the adequate convergent validity of the instrument. Moreover, the test–retest results demonstrated the stability of the results obtained through this questionnaire. Finally, the lifestyle categories derived from the SLIQ showed a high ability to discriminate between participants’ health profiles. Hence, it can be concluded that the Spanish version of the SLIQ questionnaire is a valid and reliable tool for the quick and effective assessment of lifestyle.
Measurement of the burdens of neonatal disorders in 204 countries, 1990–2019: a global burden of disease-based study
Authors: Xin Juan , Luo Yiwen , Xiang Wanwan , Zhu Sijing , Niu Hui , Feng Jiayuan , Sun Landi , Zhang Boxing , Zhou Xihui , Yang Wenfang 
Published: January 2024

BackgroundNeonatal disorders are facing serious public health challenges. Previous studies were based on limited data sources and had a narrow geographical scope. We aim to understand the trends of alteration in the burden of neonatal disorders from 1990 to 2019 in 204 countries and territories.MethodsData were investigated from the Global Burden of Disease Study 2019. First, we visualized the burden of neonatal disorders using the number of cases and the age-standardized incidence rate (ASIR), death rate (ASDR), and disability-adjusted life years (ASR-DALYs) from 1990 to 2019. Second, estimated annual percentage changes (EAPCs) were used to evaluate the temporal trends of disease burden during different periods. Finally, the sociodemographic index (SDI) and human development index (HDI) were used to determine whether there exists a correlation between socioeconomic development level, human development level, and potential burden consequences.ResultsOverall, in the past 30 years, the ASIR trends have remained relatively steady, whereas the ASDR and ASR-DALYs have declined. However, the burden of neonatal disorders varied greatly in various regions and countries. Among 21 regions, the ASIR trend had the largest increase in Central Latin America (EAPC = 0.42, 95%CI = 0.33–0.50). Conversely, the ASDR and ASR-DALYs experienced the largest decrease in Central Europe (EAPC = −5.10, 95%CI = −5.28 to 4.93) and East Asia (EAPC = −4.07, 95%CI = −4.41 to 3.73), respectively. Among 204 countries, the ASIR (EAPC = 3.35, 95%CI = 3.13–3.56) trend in Greece displayed the most significant increase, while the ASDR (EAPC = 1.26, 95%CI = 1.01–1.50) and ASR-DALYs (EAPC = 1.26, 95%CI = 1.03–1.49) trends in Dominica experienced the most substantial increase. Furthermore, there was a strong correlation between the EAPCs in ASIR, ASDR, ASR-DALYs, and SDI or HDI in 2019, with some exceptions. In addition, countries with elevated levels of HDI experienced a faster increase in ASDR and ASR-DALYs for neonatal disorders.ConclusionAlthough the burden of neonatal disorders shows a downward trend from 1990 to 2019, it is still not optimistic. It is necessary to implement a multi-pronged approach to reduce the increasing burden of neonatal disorders.
KOMPETENSI LITERASI DATA DAN INFORMASI MEDIA SOSIAL APARATUR PEMERINTAH DESA CIBURIAL DAN KELOMPOK MASYARAKAT INFORMASI
Authors: Windyaningrum Rachmawati 
Published: January 2024

Desa Ciburial mengembangkan sistem informasi melalui media sosial sebagai media penyebaran informasi desa. Media sosial yang aktif dikelola Desa Ciburial terdiri dari Twitter, Facebook, Instagram, Youtube, dan Pinterest. Pengelolaan informasi di media sosial membawa Desa Ciburial sebagai peraih Juara Pertama Pengelolaan Media Sosial Terbaik Se-Jawa Barat pada ajang Jabar Juara Award tahun 2020. Penelitian ini bertujuan untuk mengungkapkan kompetensi literasi data dan informasi aparatur pemerintah desa ciburial dan kelompok masyarakat informasi. Metode penelitian yang digunakan adalah kualitatif dengan studi kasus. Adapun teknik pengumpulan data secara primer dilakukan melalui observasi non partisipan, wawancara mendalam dan focus group discussion, sedangkan data sekunder didapatkan melalui studi literatur buku, jurnal, arsip atau dokumen pemerintah desa, serta pencarian internet. Analisa data yang digunakan adalah model Miles dan Huberman serta triangulasi data dilakukan dengan triangualasi data, sumber dan waktu sebagai teknik keabsahan data. Hasil penelitian menunjukan kompetensi literasi data ditunjukkan pada keahlian ASN dan Kelompok masyarakat Informasi Desa Ciburial dalam mengaktifkan media sosial sebagai penunjang perluasan penyebaran informasi desa. Kebutuhan informasi disesuaikan dengan keperluan masyarakat yakni kegiatan desa dan potensi desa sebagai desa wisata. Evaluasi yang dilakukan adalah mengevaluasi keaktifan masyarakat dalam mengakses Instagram, karena masih banyak masyarakat yang belum sepenuhnya mengakses media sosial.

Kata Kunci: Kompetensi, Literasi, Media Sosial, Instagram
Situation administrative des jeunes étrangers à partir de l’âge de 16 ans
Authors: Planche Anne ,   CNDP Migrants
Published: January 2024

Pour vivre en France avant 16 ans, l’enfant étranger doit seulement pouvoir justifier de son identité. Mais à l’âge de 16 ans, il doit «se mettre en règle», c’est à dire montrer un titre de séjour pour résider en France. S’il veut travailler, il lui faut obtenir un titre de travail.
Avant d’entrer dans les détails d’une règlementation complexe et changeante, il convient de caractériser l’esprit général de cette règlementation puis d’attirer l’attention sur un certain nombre de précautions à prendre.
Caractéristiques de la règlementation
Aucune législation générale ne définit le statut du jeune immigré. En effet :
Des femmes immigrées écrivent un recueil de contes
Authors: Patte Véronique 
Published: January 2024

Au cours de l’année 1977-1978, j’ai travaillé dans la banlieue parisienne, à Genevilliers, pour un organisme qui assurait des cours auprès des femmes immigrées. En février, j’ai fait la connaissance des institutrices de classes maternelles des enfants de nos stagiaires. Elles déploraient leur manque de contacts avec les mères, et en cas de contacts, les obstacles linguistiques. Les femmes regardaient à peine ce que les enfants avaient fait, disaient en souriant « oui, oui » et repartaient. En accord avec les institutrices, j’ai proposé aux femmes d’écrire un petit recueil de contes de leurs pays que nous ferions ronéoter ou photocopier et que nous distribuerions dans les écoles du quartier. Les institutrices pourraient ainsi raconter des histoires d’Afrique du Nord ou d’Afrique Noire aux enfants français qui entendraient parler un peu d’autre chose que de la France. Quant aux enfants immigrés, ils apprécieraient sans doute que la maîtresse parle de leur culture pendant la classe, qu’elle raconte des histoires que peut-être ils connaîtraient déjà, et qui les transformeraient dans la classe en pôles d’attraction. L’école est un des principaux lieux où les femmes immigrées ont un contact direct avec la société française, et les enfants sont un de leurs principaux centres d’intérêt. Il me semblait intéressant de les toucher par ce biais pour les mettre en relation avec la société et avec une institution essentielle dans une relation où elles auraient un rôle positif, où elles seraient celles qui apportent quelque chose et quelque chose qui leur est propre. Je voyais là une façon de les intéresser à l’école, dont elles se sentaient exclues, et de s’y intéresser pour avoir leur mot à dire, en tant que mères d’enfants immigrés.
Septembre 2007. De « communauté» à « communautarisme »
Authors: Mayol Pierre 
Published: January 2024

En France, autant le mot « communauté » a la cote, autant celui de « communautarisme » est mal vu. On trouvera dans les ouvrages spécialisés l’histoire des deux mots. Un parcours sémantique est l’étape préalable de toute interprétation sociale, politique ou philosophique. Que voulons-nous dire quand nous employons ces mots ? Que dit l’étymologie ?
Une académie se mobilise contre les discriminations
Authors: Ukropina Laurence 
Published: January 2024

Présenter l'action de l'académie de Nancy-Metz en faveur de la lutte contre les discriminations, c'est parler de ce couple qui semblait impensable : l'école et la discrimination. Impensable car occulté en raison d'une vision de l'école perçue comme un « sanctuaire républicain » et tout au plus victime de processus extérieurs qui parviendraient, dans des cas marginaux et récents, à pénétrer son enceinte.
Strategic Aspects of Space Medicine: A Journey from Conventional to Futuristic Requisites
Authors: Wani Ashwini , Prabhakar Bala , Shende Pravin 
Published: January 2024

Space-travel system comes with a number of difficulties that endanger the astronauts' survival in the intensely radiative environment by adversely affecting their physiological functions such as muscle deterioration, bone loss, kidney stones, infection, genetic disorder, and cardiovascular adaptation. The maintenance of pharmaceutical stability is a crucial parameter to prevent faster degradation processes of therapeutics, loss of active medication potency, and time-dependent alterations in pharmacokinetic and pharmacodynamic studies attributing to varied physiological changes under microgravity. The desired long shelf-life of medications and the stability studies cannot be completely based on terrestrial environment guidelines but rather include unique spaceflight conditions like microgravity, excessive radiation especially the galactic cosmic rays and solar particle events, vacuum, and variations in relative humidity. This review article mainly focuses on the sources and effects of instability-causing factors like humidity, temperature, radiation, and microgravity with cutting-edge solutions to address such problems using currently practiced methods and advanced future potential innovations. The future outlook of space medicine using technology as its backbone includes 3D printing, Bio-MOD systems, in vitro transcription, CRISPR, and tissue-on-chip and nano-implantable devices for the development of just-in-time and personalized medicines. The researchers and organizations around the globe like Translational Research Institute for Space Health (TRISH), National Aeronautics and Space Administration (NASA), Defense Advanced Research Projects Agency (DARPA), European Space Agency (ESA), National Center for Advancing Translational Sciences (NCATS), and National Institute for Biomedical Imaging and Bioengineering (NIBIB) are strategizing and envisaging the various vicissitudes for the development of space medicine.
Peran Badan Nasional Penanggulangan Terorisme (BNPT) Dalam Menanggulangi Radikalisme Dan Terorisme Di Indonesia
Authors: Agustin Indri Ceria , Tantimin, S.H, M.H.  , Situmeang, S.H, M.H. Dr. Ampuan 
Published: January 2024

Tindakan radikal terorisme ialah jenis kejahatan luar biasa (extraordinary crime) dan termasuk kejahatan kemanusiaan (againt humanity), serta kejahatan lintas negara (borderless), sehingga membutuhkan penanganan dan penanggulangan dengan langkah yang luar biasa (extraordinary measure). Penelitian ini bertujuan menjelaskan secara peran, tugas, dan kewenangan BNPT RI dalam penanggulangan terorisme di Indonesia dan menjelaskan secara mendalam program-program BNPT RI dalam upaya penanggulangan dan menganalisa lebih implementasi peran BNPT RI pada program-program dalam penanggulangan terorisme di Indonesia.
Studi ini tergolong sebagai jenis penelitian lapangan (field research). Studi ini berupaya menggali data-data yang berkaitan dengan peran BNPT RI dalam penanggulangan terorisme. Pendekatan dalam penelitian ini yaitu metode kualitatif. Riset ini mendayagunakan analisis kualitatif.
Hasil penelitian ini mengungkapkan bahwa peranan, tanggung jawab, dan kewenangan BNPT RI dalam mengatasi aksi radikal terorisme, selaras dengan UU No. 5 Tahun 2018, mencakup: a. Membentuk regulasi, strategi, dan program nasional di sektor pencegahan terorisme; b. Mengoordinasikan badan pemerintahan berkenaan dengan tata laksana dan eksekusi regulasi pencegahan terorisme; c. Mengimplementasikan regulasi tersebut melalui satuan tugas yang mencakup elemen-elemen instansi pemerintahan terkait, sejalan dengan peran, fungsi, dan wewenang masing-masing. BNPT RI sebagai leading sector. Dengan program-program dari BNPT RI, maka akan mempersempit ruang gerak kelompok radikal terorisme. Adapun implementasi peran BNPT RI dalam penanggulangan radikal terorisme, yaitu 1). Program Sinergisitas dalam Mencegah Terorisme, 2). Mewujudkan Sinergi untuk Indonesia Harmoni, dan 3). Strategi Membangun Perdamaian Global dalam Penanggulangan Terorisme.
Strategi Pengembangan Wisata Budaya Keraton Sumenep di Kelurahan Pajagalan, Kecamatan Kota Sumenep, Kabupaten Sumenep, Jawa Timur
Authors: Poerwati Titik , Desderius Kevie , Lidya Subnafeu Eglantyne , Parmanes Ester , Rangga Saputra Dityanda , Aprilianus Dapa Yohanes 
Published: January 2024

Keraton Sumenep merupakan salah satu destinasi wisata budaya unggulan di Kabupaten Sumenep, karena memiliki nilai budaya yang menarik. Akan tetapi, Keraton Sumenep masih mendapati berbagai kendala dalam perjalanannya seperti rendahnya minat pengunjung, kurangnya aktivitas wisata yang menarik, dan belum lengkapnya fasilitas sehingga wisata budaya ini belum secara optimal memberikan dampak positif, terkhususnya secara ekonomi kepada masyarakat. Oleh karena itu dibutuhkannya sebuah kajian untuk menganalisis karaktersitik kawasan wisata Keraton Sumenep dan strategi pengembangannya. Untuk mencapai tujuan tersebut dilakukan analisis deskriptif karakteristik pariwisata budaya di kawasan wisata yang terdiri atas atraksi, amenitas, aksesibilitas, akomodasi, aktivitas dan nilai budaya, serta analisis faktor Internal dan Eksternal di kawasan wisata seperti kekuatan, kelemahan, peluang dan ancaman. Berdasarkan hasil analisis, diketahui bahwa karakteristik kawasan Keraton Sumenep berdasarkan enam variabel penelitian adalah sebagai berikut; faktor atraksi terdiri atas bangunan bersejarah, museum keraton, dan ikon peninggalan sejara. Faktor amenitas terdiri atas pusat informasi, dan pusat oleh-oleh (UMKM). Dari segi Aksesibilitas, kemudahan untuk menjangkau Keraton Sumenep sudah sangat baik, karena berada tepat di pusat kota, bisa di tempuh melalui berbagai arah, dan kondisi jalan yang bisa di lewati oleh semua jenis kendaraan, Faktor akomodasi nya terdiri dari homestay dan hotel di sekitar Keraton, selanjutnya aktivitas wisata yang bisa dilakukan di kawasan wisata Keraton Sumenep adalah menjelajahi lokasi keraton dan mengunjungi museum Keraton. Untuk nilai budaya nya terdiri atas sejarah dan tradisi Keraton Sumenep. Berdasarkan hasil analisis SWOT diketahui strategi pengembangan yang dilakukan adalah fokus untuk mengatasi kelemahan untuk meraih peluang. Sehingga dirumuskan tiga strategi pengembangan yaitu optimalisasi kelengkapan fasilitas wisata, pengembangan ekonomi lokal, dan pengadaan aktivitas wisata yang menarik.
Association of Microalbuminuria with Glycemic Status Among Patients with Diabetes Mellitus
Authors: Parkash Kumar  , Chandra Essar Mal  , Muhammad Aslam Rind  , Harender Kumar  , Tanveer Ahmed Talpur  
Published: January 2024

Objectives: To evaluate the association between micro-albuminuria and glycemic status among type 2 diabetic patients in Hyderabad, Sindh.
Methods: Cross Sectional study was conducted at the Medical unit of Isra University, Hyderabad from January 2019 to June 2020. All the patients aged between 30 and 50 years, of either genders, with both good controlled as well as uncontrolled diabetes mellitus type II admitted in the medicine ward were included. All the participants were divided into two groups according to their glycemic level. The Group I comprised of patients with poor glycemic control that is HbA1c >7% while Group II comprises of patients with good glycemic control that is HbA1c<7%.
Results: Majority (56.4%) of participants in the study were Male while most (31.0%) them belongs to age group 41-45 years. The mean age of all patients was 42.3 ± 4.1 years. The mean HbA1c level in group 1(poorly controlled) and 2 (good control) participants was 8.04± 0.97% and 5.87 ± 0.44%. There was a statistically significant association (p<0.05) between poorly controlled glycemic status and micro-albuminuria.
Conclusion: Micro-albuminuria is significantly associated with the poor glycemic status among type 2 diabetic patients.
Ultra-wideband longitudinally coupled-resonator filters on lithium niobate using periodically slotted SiO2 as an acoustic coupler
Authors: Wu Ting , Luo Hua-yong , Feng Yi-wei , Bao Jing-fu , Hashimoto Ken-ya 
Published: January 2024

Abstract
This paper discusses the applicability of periodically slotted SiO2 as a coupler for ultra-wideband longitudinally coupled-resonator filters. It is shown that a −3 dB fractional bandwidth of more than 31% can be achieved by using lower-order three resonance modes. It is also shown that a periodically slotted SiO2 structure can also control the frequency dispersion of wave propagation along the surface, and transverse modes are suppressed well for one particular mode under a proper setting. Then the piston design is applied for the remaining two modes, and the spurious-free and flat-passband triple-mode filter is synthesized.
A Miskolci Egyetem A/2 épülete LDV módszerrel mért rezgéseinek időbeli változásai
Authors: Béres Miklós , Jenyó Tamás , Paripás Béla 
Published: January 2024

LDV (Laser Doppler Vibrometer) interferométerrel mértük az A/2 épület keresztirányú igen gyenge (kisebb mint 1µm amplitúdójú) rezgéseit. A méréseket a lézer laboratóriumunk belső falán végeztük mobil rezgésmentes asztalra helyezett berendezéssel. Az időbeli mérések az épület más pontjain más időpontokban végzett mérésekkel történő összehasonlíthatóság végett szükségesek. Azt találtuk, hogy a rezgések az épületbeli emberi tevékenységgel szoros kapcsolatban vannak, hétköznap erősebbek, mint hétvégén, munkaidőben erősebbek, mint azon kívül. Az órás frekvencia spektrumok munkanapokon 9 ‑ 16 óra között viszonylag stabilak, különösen az 5 Hz alatti tartományban.
On pexider additive functional equations
Authors: Glavosits Tamás , Karácsony Zsolt 
Published: January 2024

Let Y(+) egy Abelian group, D in Z2 ( Z(+,≤) denotes the ordered group of the integers).Dx:={uϵZ | exists vϵ X; (u,v)ϵ D}, Dy:={vϵZ | exists uϵ X; (u,v)ϵ D}, Dx+y:={zϵZ | exists (u,v)ϵ D; z=u+v}.The aim of the article is to find sets D in Z2 that the general solution of the functional equation f(x+y) = g(x) + h(y) ((x,y ϵ D) with unknown functions f, g and h is in the form of f(u)=a(u)+C1+C2 (uϵDx+y), g(v)=a(v)+C1 (vϵDx); h(z)=a(z)+C2 (zϵDy) where a is an additive function, C1, C2 ϵ Y are constants).