bluuebunny/crossref_metadata_2025_split huggingface dataset:
Kaedah Pendidikan Kerohanian Insan dalam Manuskrip Hidayah al-Salikin
Authors: Hussin Shohana 
Published: October 2023

Abstrak: Artikel ini bertujuan mengemukakan pendekatan kerohanian yang terkandung dalam manuskrip Hidayah al-Salikin sebagai kaedah pendidikan kerohanian insan yang boleh dijadikan asas kepada penyempurnaan pendekatan pendidikan Islam yang sedia ada, disamping mengukuhkan kefahaman pemikiran pendidikan Islam menerusi warisan sejarah keintelektualan ulama Melayu Nusantara. Kaedah pendidikan kerohanian Islam telah di angkat sebagai satu pendekatan pendidikan insan yang berjaya dikemukakan oleh Syeikh Abdul Samad al-Falimbani menerusi manuskrip Hidayah al-Salikin. Khazanah keilmuan ulama Melayu yang terkandung dalam manuskrip ini adalah sesuatu yang perlu diberi perhatian dan dijadikan asas penting kepada usaha memenuhi tuntutan Falsafah Pendidikan Islam dan Falsafah Pendidikan Kebangsaan kini, yang turut menekankan sentuhan elemen pendidikan yang sama iaitu aspek pembinaan kerohanian dan emosi insan yang seimbang. Bagi menyempurnakan kajian ini, metodologi kajian kepustakaan menerusi analisis kandungan telah digunakan. Hasil dapatan kajian membentangkan sejumlah kaedah dan pendekatan pendidikan kerohanian insan dalam manuskrip Hidayah al-Salikin yang boleh diterapkan dalam usaha mengembalikan adab kesantunan kepribadian insan berteraskan pendidikan kerohanian Islam sebenar.

Abstract: This article aims to present the spiritual approach contained in the Hidayah al-Salikin manuscript as a method of human spiritual education that can be used as a foundation for refining the existing approach to Islamic education, as well as enhancing the understanding of Islamic educational thought through the intellectual legacy of Malay Nusantara scholars. The method of Islamic spiritual education has been accepted as an approach to human education, as presented by Sheikh Abdul Samad al-Falimbani in the Hidayah al-Salikin manuscript. The scholarly treasure of Malay scholars contained in this manuscript must be taken seriously and utilised as an important basis for efforts to meet the requirements of Islamic Education Philosophy and the current National Education Philosophy, both of which emphasise the same educational element, namely the aspect of fostering spirituality and balanced human emotions. The content analysis of the literature review methodology was applied to complete this study. The study found that the Hidayah al-Salikin manuscript contains a variety of ways and approaches that the human spiritual education can be applied to restore the manners of human personality based on the true Islamic spiritual education.
Komponen dalam Pembangunan Model Kurikulum Agro Menurut Perspektif Islam
Authors: Abdullah Muhammad Yusuf Marlon 
Published: October 2023

Abstrak: Pertanian merupakan kerjaya yang memenuhi keperluan ekonomi negara mampu menyelesaikan keperluan masyarakat seperti bekalan daging, sayur-sayuran dan perkara-perkara yang melibatkan penternakan dan pertanian. Sebanyak 551 ayat atau bersamaan 8.8% dari keseluruhan al- Qur’an berkaitan dengan bidang agro. Allah SWT telah memerintahkan manusia agar memakmur dan memajukan bumi ini termasuklah bidang agro. Kertas kerja ini ingin mengenal pasti komponen-komponen penting dalam membangunkan model kurikulum agro menurut perspektif Islam. Metodologi kajian ini adalah berbentuk kualitatif iaitu menggunakan tinjauan iaitu kaedah temu bual. Hasil kajian mendapati bahawa antara komponen penting dalam membangunkan kurikulum agro menurut perspektif Islam adalah pengurusan kandang, pengurusan induk/anak, pengurusan makanan, pengurusan penyakit/rawatan, pengurusan baja organik dan pengurusan pemasaran. Impak daripada kajian ini akan memberikan gambaran awal terhadap komponen-komponen penting dalam membangunkan kurikulum agro daripada perspektif Islam yang boleh digabungkan dengan bidang lain seperti bidang tahfiz atau sains sosial untuk menaik taraf kehidupan masyarakat di Malaysia.

Abstract: Agriculture is a career that meets the needs of the country's economy, able to meet the needs of the community such as the supply of meat demand, vegetables and anything which involve livestock and agriculture. A total of 551 verses or equivalent to 8.8% of the entire Holy Al- Qur'an are related to agriculture. Allah SWT has ordered humans to prosper and develop this world including agro field. This paper wants to identify the important components in developing an agro curriculum model according to the Islamic perspective. The methodology of this study is qualitative, which uses a survey which is an interview method. The results of the study found that among the important components in developing an agro curriculum according to an Islamic perspective are barn management, parent/offspring management, food management, disease/treatment management, organic fertilizer management and marketing management. The impact of this study will provide an initial overview of the important components in developing an agro curriculum from an Islamic perspective that can be combined with other fields such as the field of tahfiz or social science to upgrade community life in Malaysia.
Kedudukan Ilmu Falsafah dalam Islam Menurut Al-Ghazālī (1058-1111 M)
Authors: Abd. Rahman Kamal Azmi 
Published: October 2023

Abstrak: Abū Hamīd al-Ghazālī merupakan ilmuwan Islam yang telah menguasai pelbagai bidang ilmu Pengajian Islam seperti fiqh, akidah, akhlak dan tasawuf. Penulisan Iḥyā’ ʿUlūm al-Dīn yang mengharmonikan cabang-cabang keilmuwan Islam telah membuktikan kesarjanaan al-Ghazālī. Walaupun begitu, beliau juga telah memberikan sumbangan yang signifikan dalam bidang falsafah dan pemikiran. Antara karya beliau dalam bidang falsafah ialah Maqāṣid al-Falāsifah, Tahāfut al-Falāsifah dan al-Munqidh min al-Ḍalāl. Karya-karya tersebut menjelaskan kritikan beliau terhadap falsafah terutamanya falsafah Yunani. Oleh yang demikian, artikel ini akan membincangkan tentang kedudukan falsafah dalam Islam menurut pandangan al-Ghazālī. Penulisan ini akan merujuk kepada karya al-Ghazālī terutamanya autobiografi beliau yang terkenal iaitu al-Munqidh min al-Ḍalāl. Dalam membincangkan tentang kedudukan falsafah dalam Islam, al-Ghazālī telah meletakkan satu neraca pertimbangan yang adil dan berhikmah. Beliau telah memberikan peringatan kepada mereka yang meminati falsafah dan bersikap lunak terhadapnya bahawa terdapat bahaya dalam menerima falsafah secara total, manakala terdapat bahaya menolak falsafah bagi mereka yang lantang mengkritik dan menolak falsafah. Ini kerana menurut al-Ghazālī, terdapat manfaat dalam ilmu falsafah dan pada masa yang sama terdapat mudaratnya. Oleh itu, sikap kritis dan pendekatan berhikmah yang telah dibentangkan oleh al-Ghazālī dalam falsafah ini boleh dijadikan panduan bagi cendiakawan Islam pada hari ini dalam menghadapi ilmu asing terutamanya yang datang daripada Barat.

Abstract: Abu Hamīd al-Ghazālī is an Islamic scholar who has studied various fields of Islamic Studies such as fiqh, theology, ethics and sufism. The writing of Iḥyā' ʿUlūm al-Dīn which harmonizes the branches of Islamic science has proved al-Ghazālī’s scholarship. Even so, he has also made significant contributions in the field of philosophy and thought. Among his works in the field of philosophy are Maqāṣid al-Falāsifah, Tahāfut al-Falāsifah and al-Munqidh min al-Ḍalāl. The works explain his criticism of philosophy, especially on the Greek philosophy. Therefore, this article will discuss the position of philosophy in Islam according to al-Ghazālī. This writing will refer to al-Ghazālī’s work, especially his famous autobiography, al-Munqidh min al-Ḍalāl. In discussing the position of philosophy in Islam, al-Ghazālī has put a fair and wise balance of judgment. He has warned those who are interested in philosophy and are lenient towards it that there is a danger in accepting philosophy in total, while there is also a danger in rejecting philosophy for those who loudly criticize and reject philosophy. This is because according to al-Ghazālī, there are benefits in philosophy and at the same time there are harms. Therefore, the critical attitude and wise approach presented by al-Ghazālī in philosophy can be used as a guide for Islamic scholars today in facing foreign knowledge, especially from the West.
Effects of semen quality on pregnancy rate in artificially inseminated dairy cows
Authors: Hossain MK , Howlader MMR , Alam MGS 
Published: October 2023

The study aimed to evaluate the quality of fresh and frozen-thawed semen of five adult Holstein-Friesian crossbred bulls and the pregnancy rate of cows inseminated with frozen semen of those bulls. The fresh semen of breeding bulls collected for artificial insemination (AI) programme in the field was of good quality with volume (6.7 ± 0.2 ml - 8.9 ± 0.5 ml), concentration (904.2 ± 56.4 million/ml), mass activity (3.3 ± 0.2-3.6 ± 0.2), total motility (77.0 ± 1.1% – 92.1 ± 0.6%), progressive motility (67.0 ± 1.2% – 87.4 ± 0.6%) and semen viability (73.0 ± 0.6% to 85.4 ± 0.7%). The computer assisted sperm analysis (CASA) results showed that diluted pre-freezing semen had good sperm total motility (50.1 ± 3.8 % to 59.0 ± 4.7%), progressive motility (30.0 ± 1.2%-39.0 ± 1.6%), the velocity traits of straight linear velocity (VSL), curvilinear velocity (VCL) and average path velocity (VAP) of sperm ranged from 48.0 ± 1.3 - 71.3 ± 0.7 μm/s,118.1 ± 2.8-181.3 ± 10.9 μm/s and 68.4 ± 2.5 to 91.0 ± 2.9 μm/s, respectively. Bull 1 showed significantly higher VSL (71.3 ± 0.7 μm/s), VCL (181.3 ± 10.9 μm/s) and VAP (91.0 ± 2.9 μm/s) compared to others. Viability of frozen-thawed semen was lower in Bull 5 (73.0 ± 1.71%) compared to others. Although in frozen-thawed semen these parameters declined, the semen was sufficiently good to be used in AI in the field. The overall pregnancy rate using frozen semen was 55.6% and the highest pregnancy rate (62%) was in cows that were inseminated with frozen semen of Bull 1, but the differences between bulls was not significant. The pregnancy rate had positive correlation with sperm count, total motility, progressive motility, VCL, VSL, VAP, amplitude of lateral head displacement (ALH), beat cross frequency (BCF), linearity (LIN), straightness (STR), sperm viability. In artificially inseminated cows, the intensity of oestrus of cows, timing of AI, site of semen deposition and season had a significant effect on pregnancy rate. In conclusion, the fresh and frozen-thawed semen of breeding bulls supplied in North-East Bangladesh for AI programme were good quality. Heat detection and insemination timing need to be improved to increase the pregnancy rate.
Bangl. vet. 2022. Vol. 39, No. 1-2, 1–15
Management of pregnancy failure in cows with vaginal stimulation and hormone therapy
Authors: Biswas S , Swarna M , Biswas D , Paul AK 
Published: October 2023

The focus of this study is to improve the pregnancy rate of cattle using different interventions with the analysis of associated risk factors. A total of 180 cows with pregnancy failure after one insemination were selected, which showed normal oestrous behaviour and vaginal mucus discharge. The animals were divided into six groups: A [control: with only Artificial Insemination (AI)]; B [penis-like device (PLD) used after AI]; C [intramuscular injection (im) of 2 ml prostaglandin-F2α at day 7 of the oestrous cycle and AI at observed oestrus], D [AI at natural oestrus followed by 2.5 ml GnRH im, repeated 4-6h after AI], group E [As group C and PLD used after AI], group F [as D and PLD used after AI]. The overall pregnancy was 55.6%. Group F had the highest pregnancy rate (70.0%). Higher pregnancy rates were in older animals of more than 4.6 years of age with parity of more than two. A significant correlation was found between age and parity; age and Artificial Insemination Technician (AIT); Body Condition Score (BCS) and breed; Reproductive Health (RH) and AIT. It is suggested that the use of hormonal treatments (with or without PLD) improved the pregnancy rate in cattle.
Bangl. vet. 2022. Vol. 39, No. 1-2, 16–25
Detection of SARS-CoV-2 using a laboratory-developed ultra-fast NextGenPCR test versus a conventional RT-PCR test
Authors: Čurová Katarína , Lovayová Viera , Nagyová Mária , Siegfried Leonard , Donič Viliam , de Vos Gert 
Published: October 2023

The reverse transcription polymerase chain reaction (RT-PCR) is considered the gold standard method for the detection of viruses in a clinic. The aim of this study was to compare the ability of conventional RT-PCR test (FTDTM SARS-CoV-2 Test) and laboratory-developed ultra-fast PCR test (NextGenPCRTM SARS-CoV-2 RT-PCR Reagent Kit) to detect the coronavirus SARS-CoV-2 causing COVID-19. A total of 318 nasopharyngeal swab specimens were collected from people under investigation for COVID-19. Despite the collection of two swab specimens from each patient and their different processing, the analysis showed an overall agreement of 95.9% between the conventional and laboratory-developed tests. The positive percentage agreement was 90.5% (114/126) and the negative percentage agreement was 99.5% (191/192). The ultra-fast NextGenPCR method does not require the isolation of RNA, provides a result of 20–96 specimens within 57–82 min after sampling, and offers a simple procedure of sample processing, analysis, and evaluation. Our results indicate that this method can be considered a potential diagnostic method for the detection of SARS-CoV-2 virus in hospitals, healthcare facilities, and research laboratories.
Association of overweight, obesity and risk of urinary incontinence in middle-aged and older women: a meta epidemiology study
Authors: Shang Xin , Fu Yu , Jin Xiaoqin , Wang Chenxiao , Wang Ping , Guo Panpan , Wang Ying , Yan Shuxun 
Published: October 2023

AimsThe aim of this meta-analysis is to evaluate the potential correlation between obesity and overweight, and the vulnerability to urinary incontinence (UI) in women aged middle-aged and above.MethodsWe searched PubMed, Cochrane Library, and Embase for observational studies published between the inception of the databases and April 25, 2023. A fixed-effects model was used when the P&gt;0.1 and the I2 ≤ 50%. In cases where I2 ≥ 50% (indicating significant heterogeneity), a random-effects model was applied. For the purpose of evaluating publication bias, a funnel plot and Egger’s test were used. Stata 14.0 was used for all statistical analyses.FindingsThis meta-analysis includes 16 observational studies, covering29,618 individuals. The pooled analysis shows that being overweight(25 kg/m2≤BMI&lt;30kg/m2) in middle-aged and elderly women is more likely to develop UI (OR=1.27; 95% CI: 1.17-1.37; I2 = 51.8%, P=0.013). Middle-aged and elderly women with obesity(30 kg/m2≤BMI&lt;35 kg/m2) are significantly more likely to develop UI (OR=1.60; 95% CI: 1.42-1.81; I2 = 71.8%, P=0.000). In addition, the results indicated a higher probability of UI in middle-aged and older women with obesity class II (BMI≥35 kg/m2) (OR=1.85; 95% CI: 1.59-2.16; I2 = 48.1%, P=0.103). In subgroup analysis, there is no direct relationship between the obesity in middle-aged and elderly women and an increased risk of stress urinary incontinence (SUI) (OR=1.31; 95% CI: 0.99-1.74; I2 = 63.7%, P=0.011). In middle-aged and elderly women with obesity are more likely to develop urgent urinary incontinence (UUI) (OR=2.11; 95% CI: 1.54-2.89; I2 = 80.2%, P=0.000).ConclusionIn this meta-analysis, overweight and obesity are associated with an increased risk of UI in middle-aged and elderly women. Obesity and overweight are independent risk factors for UI, as demonstrated by this study.Systematic Review Registrationhttps://www.crd.york.ac.uk/PROSPERO/, identifier CRD42023421986.
Disturbed bone marrow adiposity in patients with Cushing’s syndrome and glucocorticoid- and postmenopausal- induced osteoporosis
Authors: Sørensen Nina N. , Andreasen Christina M. , Jensen Pia R. , Hauge Ellen M. , Bollerslev Jens , Delaissé Jean-Marie , Kassem Moustapha , Jafari Abbas , Diaz-delCastillo Marta , Andersen Thomas L. 
Published: October 2023

BackgroundSkeletal stem/progenitor cells (SSPCs) in the bone marrow can differentiate into osteoblasts or adipocytes in response to microenvironmental signalling input, including hormonal signalling. Glucocorticoids (GC) are corticosteroid hormones that promote adipogenic differentiation and are endogenously increased in patients with Cushing´s syndrome (CS). Here, we investigate bone marrow adiposity changes in response to endogenous or exogenous GC increases. For that, we characterize bone biopsies from patients with CS and post-menopausal women with glucocorticoid-induced osteoporosis (GC-O), compared to age-matched controls, including postmenopausal osteoporotic patients (PM-O).MethodsTransiliac crest bone biopsies from CS patients and healthy controls, and from postmenopausal women with GC-O and matched controls were analysed; an additional cohort included biopsies from women with PM-O. Plastic-embedded biopsies were sectioned for histomorphometric characterization and quantification of adipocytes. The fraction of adipocyte area per tissue (Ad.Ar/T.Ar) and marrow area (Ad.Ar/Ma.Ar), mean adipocyte profile area (Ad.Pf.Ar) and adipocyte profile density (N.Ad.Pf/Ma.Ar) were determined and correlated to steroid levels. Furthermore, the spatial distribution of adipocytes in relation to trabecular bone was characterized and correlations between bone marrow adiposity and bone remodeling parameters investigated.ResultsBiopsies from patients with CS and GC-O presented increased Ad.Ar/Ma.Ar, along with adipocyte hypertrophy and hyperplasia. In patients with CS, both Ad.Ar/Ma.Ar and Ad.Pf.Ar significantly correlated with serum cortisol levels. Spatial distribution analyses revealed that, in CS, the increase in Ad.Ar/Ma.Ar near to trabecular bone (&lt;100 µm) was mediated by both adipocyte hypertrophy and hyperplasia, while N.Ad.Pf/Ma.Ar further into the marrow (&gt;100 µm) remained unchanged. In contrast, patients with GC-O only presented increased Ad.Ar/Ma.Ar and mean Ad.Pf.Ar&gt;100 µm from trabecular bone surface, highlighting the differential effect of increased endogenous steroid accumulation. Finally, the Ad.Ar/Ma.Ar and Ad.Ar/T.Ar correlated with the canopy coverage above remodeling events.ConclusionIncreased cortisol production in patients with CS induces increased bone marrow adiposity, primarily mediated by adipocyte hypertrophy. This adiposity is particularly evident near trabecular bone surfaces, where hyperplasia also occurs. The differential pattern of adiposity in patients with CS and GC-O highlights that bone marrow adipocytes and their progenitors may respond differently in these two GC-mediated bone diseases.
Xrcc5/KU80 is not required for the survival or activation of prophase-arrested oocytes in primordial follicles
Authors: Ratnayaka-Gamage Natasha D. , Alesi Lauren R. , Zerafa Nadeen , Stringer Jessica M. , Hutt Karla J. 
Published: October 2023

IntroductionThe non-growing, meiotically-arrested oocytes housed within primordial follicles are exquisitely sensitive to genotoxic insults from endogenous and exogenous sources. Even a single DNA double-strand break (DSB) can trigger oocyte apoptosis, which can lead to accelerated depletion of the ovarian reserve, early loss of fertility and menopause. Therefore, repair of DNA damage is important for preserving the quality of oocytes to sustain fertility across the reproductive lifespan. This study aimed to evaluate the role of KU80 (encoded by the XRCC5 gene) – an essential component of the non-homologous end joining (NHEJ) pathway – in the repair of oocyte DNA DSBs during reproductive ageing, and following insult caused by the DNA-damaging chemotherapies cyclophosphamide and cisplatin.MethodsTo investigate the importance of KU80 following endogenous and exogenous DNA damage, ovaries from conditional oocyte-specific Xrcc5 knockout (Xrcc5 cKO) and wildtype (WT) mice that were aged or exposed to DNA damage-inducing chemotherapy were compared. Ovarian follicles and oocytes were quantified, morphologically assessed and analysed via immunohistochemistry for markers of DNA damage and apoptosis. In addition, chemotherapy exposed mice were superovulated, and the numbers and quality of mature metaphase- II (MII) oocytes were assessed.ResultsThe number of healthy follicles, atretic (dying) follicles, and corpora lutea were similar in Xrcc5 cKO and WT mice at PN50, PN200 and PN300. Additionally, primordial follicle number and ovulation rates were similar in young adult Xrcc5 cKO and WT mice following treatment with cyclophosphamide (75mg/kg), cisplatin (4mg/kg), or vehicle control (saline). Furthermore, KU80 was not essential for the repair of exogenously induced DNA damage in primordial follicle oocytes.DiscussionThese data indicate that KU80 is not required for maintenance of the ovarian reserve, follicle development, or ovulation during maternal ageing. Similarly, this study also indicates that KU80 is not required for the repair of exogenously induced DSBs in the prophase-arrested oocytes of primordial follicles.
Secreted and surface proteome and transcriptome of Opisthorchis felineus
Authors: Wong Yide , Pearson Mark S. , Fedorova Olga , Ivanov Vladimir , Khmelevskaya Ekaterina , Tedla Bemnet , Arachchige Buddhika Jayakody , Reed Sarah , Field Matt , Laha Thewarach , Loukas Alex , Sotillo Javier 
Published: October 2023

IntroductionOpisthorchis felineus, Opisthorchis viverrini, and Clonorchis sinensis are the most medically important species of fish-borne zoonotic trematodes. O. felineus is endemic to the river plains of Western Siberia and Eastern Europe, and it is estimated that more than 1.6 million people could be infected with this parasite. Chronic opisthorchiasis may lead to significant gastrointestinal and hepatobiliary pathology. This study aimed to identify and characterize proteins from the secreted and tegumental proteomes of O. felineus. MethodsAdult flukes were collected from experimentally infected hamsters and cultured in vitro in serum-free media. We extracted proteins from different compartments of the O. felineus secretome, including (i) soluble excretory/secretory (ES) products; (ii) secreted 15K-extracellular vesicles (EVs); and (iii) tegument. ResultsWe also generated a transcriptome using long-read sequencing, and when this was combined with high-resolution mass spectrometry, sodium dodecyl sulfate–polyacrylamide gel electrophoresis (SDS-PAGE) separation, and protein digestion, we identified 686, 894, 389, 324, and 165 proteins from the ES, 15K-EV, and the three sequentially extracted tegument (TEG) protein fractions, respectively. We conducted in-depth gene ontology and protein family analyses on the identified proteins and discussed comparisons against similar proteome data sets acquired for the Southeast Asian liver fluke O. viverrini and the Chinese liver fluke C. sinensis. DiscussionThe information from this study will form a biologically relevant data set of O. felineus proteins that could be used to develop diagnostic and therapeutic tools to manage the human cost of O. felineus infection and its associated comorbidities.