bluuebunny/crossref_metadata_2025_split huggingface dataset:
Impact of Physical Activity on the Incidence of Vascular Diseases in Adults with Type 2 Diabetes Mellitus
Authors: Karimi Aliasghar , Pezeshki Babak , Bahramali Ehsan , Ansari Amir , Dehghan Azizallah , Frajam Mojtaba , Sabet Mohammad 
Published: December 2023

Background: Diabetes mellitus (DM) is a common metabolic disease worldwide and has many complications. Vascular events are the major complication of DM, which have an important effect on mortality and disability. Physical activity (PA) enhances the vascular function by several pathways. The aim of this study was to evaluate the relationship between PA and vascular diseases in patients with DM.Â Materials and Methods: This study was performed as a case-control study extracted from a prospective epidemiological research study in Iran. Patients with type 2 DM for more than six months as a case group were compared to sex- and age-matched healthy control subjects. The metabolic equivalent of task score was used to evaluate the level of PA and blood glucose, lipid profile, body mass index, overweight, dyslipidemia, glomerular filtration rate, myocardial infarction, unstable angina, and stroke.Â Results: Overall, 1242 patients with DM were extracted, and 2484 non-DM subjects were investigated. In the case group, 355 (28.6%) and 887 (71.4%) subjects were men and women, respectively, and 710 (28.6%) men and 1774 (71.4%) women were in the control group. The mean metabolic equivalent of task score was 30 and 40.97 in the DM and non-DM groups, respectively (PË‚0.001). The frequency of myocardial infarction, stroke, and cardiac ischemia was 44 (3.5%), 37 (3%), and 267 (21.5%) in the DM group, and 54 (2.2%), 43 (1.7%), and 389 (15.7%) in the non-DM group, respectively.Â Conclusion: The incidence of vascular events associated with PA level in patients with DM and adherence to regular PA reduced vascular events and DM complications.Â [GMJ.2019;8:e1549]Â
Frequency of Left Bundle Branch Block in Patients with Acute Myocardial Infarction; A Cross-Sectional Study
Authors: Niknam Reyhaneh , Mohammadi Mahmonir 
Published: December 2023

Background: Cardiovascular disease (CVDs) is important problems in both developing and developed countries. Currently, non-invasive methods for diagnosis of CVD, especially myocardial infarction (MI), is an interesting subject in the cardiology field. Some evidence showed left bundle branch block (LBBB) is more prevalent among patients with MI. Hence, this study aimed to investigate the frequency of LBBB and their contributing factors in patients with MI. Materials and Methods: In this cross-sectional study, 150 patients with ST elevation or non-ST elevation on their admission electrocardiography who referred to Boo-Ali and Amir-Al-Momenin hospitals, Tehran from January 2016 to June 2017 entered the study. Frequency of LBBB and right bundle branch block (RBBB) in participants and the contributing factors were determined. Results: In this study, of 150 cases (mean age: 60.35Â±12.88 years), 109 (72.7%) were male, and 41 (27.3%) were female. Out of 150 cases, 12 (8%) had LBBB, 5 (3.3%) RBBB, and 133 (89.7%) had not RBBB or LBBB. Contributing factors were family history, hypertension, and history of ischemic heart disease (P<0.05). Conclusion: Eight percent of patients with myocardial infarction would develop LBBB, which is related to hypertension, and self and family history of ischemic heart disease. [GMJ.2019;8:e1576]Â
Preventive Efficacy of Dried Lime (Citrus aurantifulia) in Common Cold Among Hajj Pilgrims: A Randomized, Double-Blinded, Placebo-Controlled Clinical Trial
Authors: Mosavat Seyed Hamdollah , Pasalar Mehdi , Molavi Vardanjani Hossein , Keshavarz Mohsen , Mosaffa-Jahromi Maryam , Owji Seyed Hosein , Bagheri Lankarani Kamran 
Published: December 2023

Background: Dried lime (Citrus aurantifulia) is one of the herbal preparations used especially by Iranian pilgrims as a preventative agent and self-remedy for respiratory tracts symptoms in folklore medicine. Therefore, we evaluated the preventive efficacy of dried lime preparation in common cold among Iranian pilgrims. Materials and Methods: In this randomized, double-blinded, clinical trial patients in the drug group received dried lime capsules, 500 mg in a single dose per day for four weeks. In the placebo group, the patients received placebo capsules using the same method. The primary outcome measure in this trial was the severity of cold symptoms assessed by a self-administered questionnaire. Results: There were no significant differences between the two groups in terms of the trend of cold symptoms severity during the study period. However, in the second week, the severity of all the cold symptoms in the drug group was less, compared to the placebo, but at the end of the study, comparison of the two groups revealed no significant difference in any of the investigated options. Conclusion: The findings revealed that although the severity of all the cold symptoms in the drug group was less as compared to the placebo group, the dried lime capsule showed no statistically significant effect on the control of these symptoms in Iranian pilgrims. [GMJ.2020;9:e1462]
The Effect of Vitamin D Replacement on Patient with Subclinical Hypothyroidism: A Pilot Randomized Clinical Trial
Authors: Ahmadi Ali , Pezeshki Babak , Karimi Aliasghar 
Published: December 2023

Background: Subclinical hypothyroidism (SCH) is characterized by an elevated Thyroid Stimulating Hormone (TSH) with a normal T4. The prevalence of Vitamin D deficiency in patients SCH is high. Some studies suggested that Vitamin D supplements could be reduced serum concentration of TSH so improve SCH and prevent overt hypothyroidism. This study aims to explore the effect of vitamin D replacement on subclinical hypothyroidism. Materials and Methods: Fifty-nine patients, diagnosed with both subclinical hypothyroidism and Vitamin D deficiency by the Endocrinology outpatient clinics between January 2018 and March 2019, were included in this trial. The patients with overt hypothyroidism, cardiovascular risk factors, or positive TPO antibody, abnormal T4, and pregnant women were excluded from this study. The 40 subjects were investigated who received vitamin D supplements for two months. Analyses were conducted through paired-samples t-test and independent-samples t-test using SPSS 24 (Armonk, NY: IBM Corp). Results: The mean serum levels of TSH was decreased from 6.89 mIU/l in the pre-test to 3.34 mIU/l in the post-test, and the difference was found to be statistically significant at P<0.001. Conclusion: We found that the TSH mean level significantly dropped through the use of vitamin D supplements. Thus, it is recommended that all the patients with subclinical hypothyroidism be screened and treated with vitamin D supplements. [GMJ.2020;9:e1592]
Quality of Life among Iranian Postmenopausal Women: A Systematic Review and Meta-Analysis
Authors: Sooki Zahra , Tagharrobi Zahra , Sharifi Khadijeh 
Published: December 2023

Menopause can cause mental, physical, vasomotor, and sexual symptoms and problems, which negatively affect the quality of life (QOL). The aim of this study was to systematically evaluate QOL among Iranian postmenopausal women. This systematic review was conducted on cross-sectional studies that were published between 2000 and 2018. An online search to find studies published in English or Persian was conducted in the databases of Web of Science, PubMed, ScienceDirect, Scopus, Google Scholar, Scientific Information Database, Magiran, and IranMedex. Search key terms were â€œquality of lifeâ€, â€œmenopauseâ€, and â€œIranâ€. Fourteen studies were eligible for this study. The Strengthening the Reporting of Observational Studies in Epidemiology (STROBE) checklist was used for quality appraisal. The mean and standard deviation of QOL and its domains were extracted from the selected studies. Study data were analyzed using the Review Manager (v. 5.0) and the STATA (v. 12.0) software. The mean of total QOL among 3413 postmenopausal women was 57.89Â±12.8 (in the possible range of 0â€“174). The means of its vasomotor, psychosocial, physical, and sexual domains were 7.86Â±2.14, 19.43Â±2.05, 40.58Â±3.33, and 6.71Â±1.77, respectively. The QOL among Iranian postmenopausal women is nearly higher than the moderate level. The lowest and the highest levels of QOL are related to the physical and sexual domains, respectively. Health authorities need to develop educational interventions to promote postmenopausal womenâ€™s QOL, particularly in the physical domain. [GMJ.2020;9:e1649]
The Psychometric Properties of the Persian Version of Childhood Experience of Care and Abuse Questionnaire (CECA)
Authors: Vameghi Roshanak , Shirinbayan Peymaneh , Salavati Mahyar , Soleimani Farin , Saeedi Ahmad , Asghari-Jafarabadi Mohammad , Hemmati Sahel 
Published: December 2023

Background: The present study aimed to determine the psychometric properties of the Persian version of the Childhood Experience of Care and Abuse Questionnaire (CECA.Q), a tool based on a retrospective interview with the child. Materials and Methods: To this aim, 251 adolescents from four regions of Tehran megacity completed the questionnaire. The reliability of the questionnaire was examined, along with the face and content validity. In addition, the construct validity was evaluated by exploratory factor analysis (EFA) and confirmatory factor analysis (CFA). Results: EFA and CFA supported a 4-factor solution including motherâ€™s role scale items, fatherâ€™s role scale items, maternal behavior scale items, and paternal behavior scale items. The total variance extracted in EFA ranged from 33.9 to 60.7. The internal consistency for motherâ€™s role, fatherâ€™s role, maternal behavior, and paternal behavior was 0.61, 0.65, 0.86, and 0.9 respectively. Thus, the questionnaire had a suitable fit, as well as reasonable reliability and validity. Conclusion: The Persian version of the CECA.Q had adequate reliability and validity as a self-report measurement for childhood experience of care and abuse. [GMJ.2020;9:e1663]
Fc Receptor-Like Gene Expression in Renal Transplantation Patients
Authors: Jamshidian Tehrani Narges , Amirghofran Zahra , Shamsaeefar Ali Reza , Karachi Aida , Karimi Mohammad Hossein 
Published: December 2023

Background: It has been well-documented that the Fc receptor-like (FCRL) molecule contributes to the pathogenesis of certain autoimmune disorders. FCRL molecules belong to the immunoglobulin superfamily produced by B cells. Also, these molecules induce activating or inhibitory signals of B cells. According to this information and also considering the critical role of immune reactions in organ transplantation, the following experiment was performed to analyze the gene expression level of FCRLs in peripheral blood mononuclear cells of kidney transplant recipients. Materials and Methods: Blood samples were obtained from 32 renal transplant patients on days 1, 3, and 7 post-transplantations. Patients were divided into two groups according to the presence or absence of rejection. Also, 24 age-matched healthy subjects were enrolled as control group. After total RNA extraction from peripheral blood mononuclear cells (PBMC) and cDNA synthesis, the gene expression levels of FCRL1, FCRL2, and FCRL4 in each group were measured by real-time polymerase chain reaction. Results: Our results showed that FCRL1 expression levels in kidney transplant patients were significantly less than healthy controls. The overall FCRL2 expression level was not significantly different between them. However, at days 1 and 7, following transplantation in the non-rejected group FCRL2 level was significantly higher than the control group. Comparing the FCRL4 gene expression levels of both groups with healthy controls showed a significant decrease in the third and seventh days post-transplantation. Conclusion: It can be concluded that mononuclear cells, mainly B cells, have an essential role to play in kidney transplantation. [GMJ.2020;9:e1730]
Influences of Serotonin Hydrochloride on Adiponectin, Ghrelin and KiSS1 Genes Expression
Authors: Mahmoudi Fariba , Haghighat Gollo Khadijeh 
Published: December 2023

Background: Serotonin and kisspeptin stimulates gonadotropin-releasing hormone (GnRH) and luteinizing hormone (LH) release while ghrelin and adiponectin inhibit them. In the present experimental study, the effects of central injection of serotonin were investigated on LH concentration, KiSS1, adiponectin, and ghrelin genes expression. Materials and Methods: Fifteen Wistar male rats in three groups received saline or serotonin hydrochloride via the third cerebral ventricle. Blood samples were collected via the tail vein. Serum LH concentration and relative gene expression were evaluated by radioimmunoassay and real-time polymerase chain reaction method, respectively. Results: Serotonin significantly increased the mean serum LH concentration and KiSS1 gene expression levels compared to the saline group. Serotonin significantly decreased the mean ghrelin and adiponectin genes expression levels compared to the saline group. Conclusion: The serotonergic pathway may have stimulatory effects on hypothalamic kisspeptin synthesis, partly via inhibiting hypothalamic ghrelin and adiponectin neural activity.[GMJ.2020;9:e1767]
Developing A General Framework for National Health Information Network for Developing Countries
Authors: Moghaddasi Hamid , Rabiei Reza , Asadi Farkhondeh , Mohammadpour Ali 
Published: December 2023

Background: The National Health Information Network (NHIN) is one of the key issues in health information systems in any country. However, the development of this network should be based on an appropriate framework. Unfortunately, the conducted projects of health information systems in the Ministry of Health of Iran do not fully comply with the concept of NHIN. The present study was aimed to develop a general framework for NHIN in Iran. Materials and Methods: In this study, in the first stage, the required information about the concept of the NHIN framework and related NHIN documents in the USA and the UK were collected based on a literature review. Then, according to the results of the first stage and with regards to the structure of the Iranian health system, a general framework for Iranian NHIN was proposed. The Delphi technique was conducted to verify the framework. Results: The proposed framework for Iranian NHIN includes three dimensions; components, principles, and architecture. Over 80% of experts have evaluated all three aspects of the framework at an acceptable scale. In total, the proposed framework has been evaluated by 83.8% of the experts at an acceptable scale. Conclusion: The proposed framework was expected to serve as the starting point for moving towards the design and creation of Iranian NHIN. At any rate, the framework could be criticized, and it could only be used for the countries whose health system is similar to the structure of the health system in Iran. [GMJ.2020;9:e1792]
Mummy Induces Apoptosis Through Inhibiting of Epithelial-Mesenchymal Transition (EMT) in Human Breast Cancer Cells
Authors: Yari Khosroushahi Ahmad , Rahmani Barouji Solmaz , Shahabi Arman , Torbati Mohammadali , Fazljou Seyyed Mohammad Bagher 
Published: December 2023

Background: Mummy (Iranian pure shilajit) is a remedy with possessing anti-inflammatory, antioxidant and anticancer activities. This study aimed to examine mummy effects on epithelial-mesenchymal transition (EMT) and invasiveness of MCF-7 and MDA-MB-231 breast cancer (BC) cell lines with underlying its mechanism. Materials and Methods: The dose-dependent inhibitory effect of the mummy on cell proliferation in vitro was determined using the MTT assay. Flow cytometry and 4â€™,6-diamidino-2-phenylindole dihydrochloride staining were respectively used for quantitative and qualitative analysis of cellular apoptosis, and gene expression analysis was conducted using real-time PCR. Results: MDA-MB-231 showed more sensitivity than the MCF-7 cell line to the anticancer activity of mummy, while mummy did not exhibit significant cell cytotoxicity against human normal cells (MCF-10A). The gene expression profile demonstrated a significant decrease in TGF-Î²1, TGF-Î²R1, TWIST1, NOTCH1, CTNNB1, SRC along with an increase in E-cadherin mRNA levels in mummy treated cells compared to the untreated control group (Pâ‰¤0.05). Conclusion: Mummy triggers inhibition of EMT and metastasis in breast cancer cells mainly through the downregulation of TGFÎ²1 activity, and more studies required to find its specific anticancer activity with details. [GMJ.2020;9:e1812]
Exploring Lesson Learned From Lecturers’ Experience On Implementing Lesson Study In Higher Education
Authors: Syarifah Eva Fitriani 
Published: December 2023

In the ever-evolving landscape of education, the importance of innovative teaching methodologies cannot be overstated. One such approach that has gained substantial traction in recent years is Lesson Study. This study aims at investigating lecturers’ experience on implementing lesson study, specifically the lesson learned from lesson study. This study employed case study which involved five lecturers at higher education level as the participants. The data were gained through open ended questionnaire, interview, and documentation. The results indicated that the lessons learned that confirmed by the participants are: enhanced creativity and innovation, targeted student - centered teaching, cultivation of reflective practitioners, and building a supportive community. In conclusion, lesson study is not only gives new experience for lecturers but also new insight that can be useful for their teaching improvement.
PEMENUHAN HAK POLITIK BAGI PASIEN REHABILITASI NARKOBA
Authors: Romadhon Fazrian Noor , Budiyanto Ivan Adelansyah 
Published: December 2023

Dilatarbelakangi dari seringnya dipandang sebelah mata bagi para pasien rehabilitasi narkoba dalam memperoleh hak politik, penelitian ini mengkaji bagaimana pemenuhan hak politik bagi pasien rehabilitasi di Yayasan Pondok Remaja Inabah XVII yang terletak di Kecamatan Cihaurbeuti, Ciamis yang berada di bawah naungan Yayasan Suryalaya. Penelitian ini menggunakan metode kualitatif deskriptif dengan pendekatan studi kasus. Teknik pengambilan sampel menggunakan purposive sampling. Sedangkan teknik pengumpulan data menggunakan observasi, wawancara, dan dokumentasi. Hasil menunjukkan bahwa pemenuhan hak politik pasien rehabilitasi narkoba di Yayasan Pondok Remaja Inabah, tidak terpenuhi. Hal tersebut karena Pondok tidak memfasilitasi serta teralihkan oleh padatnya kegiatan di Pondok. Pihak KPU Kabupaten Ciamis pun belum bisa hadir karena pihak pondok tidak memberikan ruang untuk bekerjasama melakukan sosialisasi atau pendidikan politik lainnya.
Perbandingan Mode Naratif Apokaliptik dalam Teks Mosalaparwa dan Cariyos Dajal
Authors: Habibah Nurmalia 
Published: December 2023

The dynamics of the development of Javanese literature show a spirit of tolerance and welcoming towards outside elements without neglecting the original ones. This is contradictory when juxtaposed with the fact that there are currently widespread phenomena of radicalism and intolerance. Responding to these social issues, this writing at a larger level will show that cultural heritage surprisingly take off differences that trigger religion-based conflicts and shows the existence of the essence of unity in diversity through the uncovering of the meaning of literary works. At a more specific level, this paper aims to reveal the universality of the Javanese view of the eschatological crisis that ends in the Judgment Day event through a close reading of a comparison of the apocalyptic narrative mode in the text of Old Javanese Mosalaparwa and Cariyos Dajal. After examining the two narrative texts in the realm of Javanese literature, there are narrative sections that form the structure of the text and reflect apocalyptic characteristics so that these local religious texts can be placed in the category of literary texts with apocalyptic narrative mode. When looking at the end of the story, referring to the classification of the apocalyptic genre according to Collins (2014), the Mosalaparwa text belongs to the historical apocalypses sub-type and the Cariyos Dajal text pertains to the apocalypses with heavenly journeys.
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Dinamika perkembangan sastra Jawa memperlihatkan adanya jiwa toleran dan welcoming terhadap unsur dari luar tanpa abai terhadap unsur asli. Hal ini bertolak belakang apabila disandingkan dengan fakta adanya fenomena radikalisme dan intoleransi yang marak saat ini. Merespon isu sosial tersebut, tulisan ini pada tataran yang lebih besar akan menunjukkan bahwa warisan budaya justru menanggalkan perbedaan yang menjadi pemicu konflik berbasis agama dan menunjukkan adanya esensi kebhinnekatunggalikaan melalui pengungkapan makna karya sastra. Pada tataran yang lebih khusus tulisan ini bertujuan untuk mengungkap universalitas pandangan masyarakat Jawa terhadap krisis eskatologis yang berujung pada peristiwa kiamat melalui close reading terhadap perbandingan mode naratif apokaliptik dalam teks Mosalaparwa Jawa Kuna dan Cariyos Dajal. Setelah kedua teks kisah hari akhir dalam ranah sastra Jawa tersebut dicermati, terdapat bagian-bagian naratif yang membentuk struktur teks dan mencerminkan karakteristik apokaliptik sehingga teks-teks religius lokal itu dapat ditempatkan dalam kategori teks sastra bermode naratif apokaliptik. Apabila melihat akhir ceritanya, maka merujuk pada klasifikasi genre apokaliptik menurut Collins (2014), teks Mosalaparwa termasuk ke dalam sub-tipe historical apocalypses dan teks Cariyos Dajal ke dalam apocalypses with heavenly journeys.