bluuebunny/crossref_metadata_2025_split huggingface dataset:
A short history of the phosphorus index and Andrew Sharpley's contributions from inception through development and implementation
Authors: Osmond Deanna L. , Kleinman Peter J. A. , Coale Frank , Nelson Nathan O. , Bolster Carl H. , McGrath Josh 
Published: December 2023

AbstractIn the 1980s, growing recognition of agricultural phosphorus (P) sources to surface water eutrophication led to scrutiny of animal feeding operations. In 1990, the USDA‐Natural Resources Conservation Service (NRCS) invited prominent scientists to find a solution. It was at an initial meeting that Dr. Andrew Sharpley suggested that P assessment could be modeled after the Universal Soil Loss Equation, where a matrix of factors influencing P loss would be associated with farm nutrient management recommendations. After codifying the P assessment into the USDA‐NRCS 590 Nutrient Management Standard some 10 years later, 48 states chose to develop their own P Index. Sharpley, working with many others, helped develop several state P Indices. In 2000, Sharpley secured funding from the USDA‐Agricultural Research Service to support the National P Research Project, which conducted in‐field P runoff assessments using standardized rainfall simulated studies across 20 states; this allowed individual trials to be aggregated for agroecological regions that were then incorporated into specific state P Indices. Eventually, comparison of P Indices across state boundaries led to a white paper at the behest of USDA‐NRCS that resulted in three regional projects evaluating modeling approaches to support or replace P Indices. Sharpley's national umbrella project pointed to shortcomings in water quality models, such as APEX or TBET, as a replacement for state P Indices, which remain a key part of the USDA‐590 standard. As a selfless leader, capable of attracting and assembling diverse, productive interdisciplinary teams, Sharpley was essential to the inception, development, and implementation of the P Index.
Histopathologic features of selumetinib‐induced paronychia in a child with neurofibromatosis type 1
Authors: Borgia P. , Ferro J. , Piccolo G. , Striano P. , Vellone V. G. , Viglizzo G. , Diana M. C. 
Published: December 2023

AbstractWe report a 4‐year‐old girl developing therapy refractory paronychia induced by selumetinib, an oral selective inhibitor of mitogen‐activated protein kinase 1/2 prescribed for a large submandibular plexiform neurofibroma. Although this cutaneous reaction is well‐known and more prevalent in children than in adults, no histopathological characterisations of nail unit toxicity in children on selumetinib have been reported so far. We show histopathological studies on patient‐derived periungual inflamed skin to investigate the cutaneous impact of selumetinib therapy. Our findings are consistent with those of epidermal growth factor receptor inhibitors and support the role of a non‐specific immune activation rather than opportunistic infection in the underlying mechanism of the disease. Partial bilateral matricectomies with electrocautery were resolutive, and the child restarted selumetinib with no recurrence of paronychia during a follow‐up period of 3 months after nail surgery.
Value of dermatology hospital conference as a continuing medical education‐accredited activity: A retrospective review
Authors: Maniam Ganesh B. , Isaq Nasro , Wetter David A. , Cantwell Hafsa M. , McEvoy Marian T. , el ‐Azhary Rokea A. , Alavi Afsaneh , Camilleri Michael J. , Davis Mark D. P. , Sartori‐Valinotti Julio C. 
Published: December 2023

AbstractBackgroundDermatology grand rounds are popular educational activities among dermatologists and trainees, contributing to improved knowledge and skills. Dermatology hospital conferences at Mayo Clinic Dermatology are separate from dermatology grand rounds in that they focus on inpatient consultations and dermatology admissions.ObjectivesThis study aimed to determine the types of cases presented during dermatology hospital grand rounds and evaluate the educational value of this continuing medical education (CME)‐accredited activity.MethodsThis retrospective study reviewed all inpatient dermatology cases presented during hospital grand rounds at Mayo Clinic Dermatology in Rochester, MN from 2019 to 2022; this study also reviewed the compiled surveys of faculty participants at our institution from 2019 to 2022.ResultsA total of 389 cases met the inclusion criteria for analysis. The most common diagnostic category was inflammatory/autoimmune diseases (157 cases, 40%), followed by infection or infestation (73 cases, 19%), drug‐induced eruptions (49 cases, 13%), neoplastic or metastatic diseases (41 cases, 11%), genetic/congenital disorders (21 cases, 5%), depositional/nutritional/metabolic conditions (15 cases, 4%) and wound/traumatic/iatrogenic dermatoses (12 cases, 3%), which were the least common. Most cases were presented for discussion of diagnosis and management (246 cases, 63%), but others focused on the arrival of diagnosis (119 cases, 31%) or management alone (24 cases, 6%). The compiled surveys of faculty participants (n = 50) indicated high satisfaction with dermatology hospital grand rounds, with the majority expressing that evidence‐based research was incorporated and positively impacted their practice. Most respondents indicated that hospital conference participation improved knowledge (97%), competence (64%), clinician performance (54%), patient outcomes (52%) and team performance (50%).ConclusionsThe cases presented during these conferences spanned from challenging inflammatory diseases to simple dermatoses, with over 800 literature references reviewed. Dermatology hospital grand rounds provide high value as a CME‐accredited activity for dermatology faculty, even for those without a specific interest in hospital/inpatient dermatology.
Advances in machine intelligence‐driven virtual screening approaches for big‐data
Authors: Kumar Neeraj , Acharya Vishal 
Published: December 2023

AbstractVirtual screening (VS) is an integral and ever‐evolving domain of drug discovery framework. The VS is traditionally classified into ligand‐based (LB) and structure‐based (SB) approaches. Machine intelligence or artificial intelligence has wide applications in the drug discovery domain to reduce time and resource consumption. In combination with machine intelligence algorithms, VS has emerged into revolutionarily progressive technology that learns within robust decision orders for data curation and hit molecule screening from large VS libraries in minutes or hours. The exponential growth of chemical and biological data has evolved as “big‐data” in the public domain demands modern and advanced machine intelligence‐driven VS approaches to screen hit molecules from ultra‐large VS libraries. VS has evolved from an individual approach (LB and SB) to integrated LB and SB techniques to explore various ligand and target protein aspects for the enhanced rate of appropriate hit molecule prediction. Current trends demand advanced and intelligent solutions to handle enormous data in drug discovery domain for screening and optimizing hits or lead with fewer or no false positive hits. Following the big‐data drift and tremendous growth in computational architecture, we presented this review. Here, the article categorized and emphasized individual VS techniques, detailed literature presented for machine learning implementation, modern machine intelligence approaches, and limitations and deliberated the future prospects.
Development, psychometric evaluation, and factor analysis of an instrument measuring quality of life in autistic preschoolers
Authors: Lichtlé Jérôme , Devouche Emmanuel , Dialahy Isaora Zefania , de Gaulmyn Aude , Amestoy Anouck , Coutelle Romain , Isnard Pascale , Monestès Jean‐Louis , Mottron Laurent , Cappe Emilie 
Published: December 2023

AbstractIntroductionEarly interventions for autistic children should target their quality of life (QoL) but require adapted measures. The association of a child's temperament and parental characteristics with the QoL of autistic children remains unknown.MethodsWe constructed an autism module based on a thematic analysis, a Delphi survey with experts, and a pre‐test with parents to be completed alongside the proxy version of the PedsQL 4.0. We explored compliance, responsiveness, internal consistency, convergent validity, and factor structure with 157 parents of autistic preschool children. We examined the association between child and parental characteristics with the QoL of autistic children using correlation analysis, principal component analysis, hierarchical ascending classification, and linear regression. Sociodemographic information was collected via multiple choice questions, autism severity via Autism Diagnostic Observation Schedule (ADOS) scores, and parental acceptance and child's temperament via the Acceptance and Action Questionnaire and the Emotionality, Activity, and Sociability.ResultsAn autism module comprised of 27 items emerged. Psychometric evaluation resulted in a 24‐item autism module with good internal consistency and significant convergent validity. ADOS total score was not significantly related to QoL, contrary to children's sleep issues, children's emotionality, and parental acceptance.ConclusionsThe autism module is a reliable QoL proxy measure for autistic preschool children. Results suggest parental interventions targeting children's QoL.
Does dietary intake of caffeine have an effect on transient global amnesia?
Authors: Zeinalabedini Mobina , Mousavi Zahra , Amjadi Arezoo , Shapouri Mahsa , Aminnezhad Kavkani Bahareh , Masoumvand Mohammad , Mobarakeh Khadijeh Abbasi , Gholamalizadeh Maryam , Valisoltani Neda , Mohammadi Saeideh , Khoshdooz Sara , Doaei Saeid , Kooshki Akram 
Published: December 2023

AbstractAimAmnesia is a cognitive disorder that may lead to memory loss. Caffeine is a psychoactive substance which have an effect on memory and cognitive functions. This study aimed to assess the association of transient global amnesia (TGA) with dietary intake of caffeine.MethodsThis cross‐sectional study was conducted on the Sabzevar Persian cohort data of 258 patients with TGA and 520 healthy individuals in Sabzevar, Iran. The Nutritional data were gathered in face‐to‐face interviews using a valid Food Frequency Questionnaire. Different models of logistic regression were used to determine the association between TGA and dietary caffeine intake after adjusting the confounders including age, sex, education, job, marital status, physical activity, BMI, and calorie intake.ResultsThere was no significant difference in terms of dietary calorie intake of (2279.5 ± 757.9 vs. 2365.5 ± 799.5, p = 0.19), protein (70.79 ± 25.27 vs. 72.94 ± 24.83, p = 0.31), fat (59.97 ± 23.79 vs. 60.13 ± 26.38, p = 0.93), carbohydrate (376 ± 134 vs. 393.1 ± 137.8, p = 0.14), and caffeine (196.4 ± 127.9 vs. 186.3 ± 128.5, p = 0.36) between the groups. No significant association was found between TGA and dietary intake of caffeine (OR: 0.99, 95% CI: 0.99–1.01, p = 0.36). The results did not change after adjusting the confounders.ConclusionsNo significant association was found between TGA and dietary intake of caffeine. Further prospective studies are required to confirm this finding.
Exposure to early‐life stress impairs weight‐loss maintenance success in mice
Authors: Foright Rebecca M. , McQuillan Tara E. , Frick Jenna M. , Minchella Paige M. , Levasseur Brittni M. , Tinoco Omar , Birmingham Lauryn , Blankenship Anneka E. , Thyfault John P. , Christianson Julie A. 
Published: December 2023

AbstractObjectiveThe impact of early‐life stress on weight‐loss maintenance is unknown.MethodsMice underwent neonatal maternal separation (NMS) from 0 to 3 weeks and were weaned onto a high‐fat sucrose diet (HFSD) from 3 to 20 weeks. Calorie‐restricted weight loss on a low‐fat sucrose diet (LFSD) occurred over 2 weeks to induce a 20% loss in body weight, which was maintained for 6 weeks. After weight loss, half of the mice received running wheels, and the other half remained sedentary. Mice were then fed ad libitum on an HFSD or LFSD for 10 weeks and were allowed to regain body weight.ResultsNMS mice had greater weight regain, total body weight, and adiposity compared with naïve mice. During the first week of refeeding, NMS mice had increased food intake and were in a greater positive energy balance than naïve mice. Female mice were more susceptible to NMS‐induced effects, including increases in adiposity. NMS and naïve females were more susceptible to HFSD‐induced weight regain. Exercise was beneficial in the first week of regain in male mice, but, long‐term, only those on the LFSD benefited from exercise. As expected, HFSD led to greater weight regain than LFSD.ConclusionsEarly‐life stress increases weight regain in mice.
Identification of risk factors associated with acute kidney injury in patients taking sodium‐glucose cotransporter‐2 inhibitors
Authors: Schumacher Christie , Chorpash Amanda , Bolch Charlotte , Eagan Kellye , Nimer Sara , Van Dril Elizabeth 
Published: December 2023

AbstractStudy ObjectiveStudies have demonstrated sodium‐glucose cotransporter‐2 (SGLT2) inhibitors are kidney protective; however, their ability to cause hemodynamic changes may predispose patients to acute kidney injury (AKI). An FDA warning recommends evaluating for factors that predispose patients to AKI before initiating a SGLT2 inhibitor. The primary objective of this study is to identify risk factors that may predispose persons with diabetes to AKI when initiating SGLT2 inhibitor therapy.DesignMulticenter retrospective cohort chart review.Data SourceStudy patients were identified through an electronic medical record generated report if they had type 2 diabetes and were prescribed a SGLT2 inhibitor from January 2013 to September 2019.PatientsPatients were included if they were receiving care at Advocate Medical Group and were confirmed to have taken one of the four SGLT2 inhibitors available at the time of study approval, canagliflozin, dapagliflozin, empagliflozin, or ertugliflozin, for at least 7 days. Patients were excluded if they did not have a basic metabolic panel or comprehensive metabolic panel recorded 1 year prior to or 6 months after SGLT2 inhibitor therapy initiation.ResultsData extraction from the electronic medical record identified 6425 patients receiving a SGLT2 inhibitor, of which 1962 met inclusion criteria and were included for analysis. Thirty‐five (1.8%) patients experienced an AKI after SGLT2 inhibitor therapy initiation. There was no statistically significant difference between groups based on background medication use (p = 0.325). At baseline, patients experiencing an AKI after SGLT2 inhibitor initiation were more likely to be older in age (p = 0.010), have a higher serum potassium (p < 0.001), blood glucose (p = 0.018), SCr (p = 0.009) and UACR (p < 0.001), and a lower eGFR (p = 0.028) compared to those who did not experience AKI.ConclusionsThe transient eGFR decline with SGLT2 inhibitor initiation should be expected and is generally not an indication to discontinue therapy. Future initiatives should be directed at increasing knowledge of monitoring recommendations for these agents.
Disparities in lung transplantation in children
Authors: Brugha Rossa , Wu Diana , Spencer Helen , Marson Lorna 
Published: December 2023

AbstractLung transplantation is a recognized therapy for end‐stage respiratory failure in children and young people. It is only available in selected countries and is limited by access to suitable organs. Data on disparities in access and outcomes for children undergoing lung transplantation are limited. It is clear from data from studies in adults, and from studies in other solid organ transplants in children, that systemic inequities exist in this field. While data relating specifically to pediatric lung transplantation are relatively sparse, professionals should be aware of the risk that healthcare systems may result in disparities in access and outcomes following lung transplantation in children.
The development of abamectin resistance in Liriomyza trifolii and its contribution to thermotolerance
Authors: Wang Yu‐Cheng , Chang Ya‐Wen , Gong Wei‐Rong , Hu Jie , Du Yu‐Zhou 
Published: December 2023

AbstractBACKGROUNDLiriomyza trifolii is an economically significant, invasive pest of horticultural and vegetable crops. The larvae form tunnels in foliage and hasten senescence and death. Outbreaks of L. trifolii often erupt in hot weather and are driven by thermotolerance; furthermore, the poor effectiveness of pesticides has made outbreaks more severe. But it is still unclear whether the development of insecticide tolerance will contribute to thermotolerance in L. trifolii.RESULTSTo explore potential synergistic relationships between insecticide exposure and thermotolerance in L. trifolii, we first generated an abamectin‐resistant (AB‐R) strain. Knockdown behavior, eclosion and survival rates, and expression levels of genes encoding heat shock proteins (Hsps) in L. trifolii were then examined in AB‐R and abamectin‐susceptible (AB‐S) strains. Our results demonstrated that long‐term selection pressure for abamectin resistance made L. trifolii more prone to develop cross‐resistance to other insecticides containing similar ingredients. Furthermore, the AB‐R strain exhibited enhanced thermotolerance and possessed an elevated critical thermal maximum temperature, and upregulated expression levels of Hsps during heat stress.CONCLUSIONCollectively, our results indicate that thermal adaptation in L. trifolii was accompanied by emerging abamectin resistance. This study provides a theoretical basis for investigating the synergistic or cross‐adaptive mechanisms that insects use to cope with adversity and demonstrates the complexity of insect adaptation to environmental and chemical stress. © 2023 Society of Chemical Industry.
Real‐world evidence to advance knowledge in pulmonary hypertension: Status, challenges, and opportunities. A consensus statement from the Pulmonary Vascular Research Institute's Innovative Drug Development Initiative's Real‐world Evidence Working Group
Authors: Morland Kellie , Gerges Christian , Elwing Jean , Visovatti Scott H. , Weatherald Jason , Gillmeyer Kari R. , Sahay Sandeep , Mathai Stephen C. , Boucly Athénaïs , Williams Paul G. , Harikrishnan Sivadasanpillai , Minty Evan P. , Hobohm Lukas , Jose Arun , Badagliacca Roberto , Lau Edmund M. T. , Jing Zhi‐Cheng , Vanderpool Rebecca R. , Fauvel Charles , Leonidas Alves Jose , Strange Geoff , Pulido Tomas , Qian Junyan , Li Mengtao , Mercurio Valentina , Zelt Jason G. E. , Moles Victor M. , Cirulis Meghan M. , Nikkho Sylvia M. , Benza Raymond L. , Elliott C. Gregory 
Published: December 2023

AbstractThis manuscript on real‐world evidence (RWE) in pulmonary hypertension (PH) incorporates the broad experience of members of the Pulmonary Vascular Research Institute's Innovative Drug Development Initiative Real‐World Evidence Working Group. We aim to strengthen the research community's understanding of RWE in PH to facilitate clinical research advances and ultimately improve patient care. Herein, we review real‐world data (RWD) sources, discuss challenges and opportunities when using RWD sources to study PH populations, and identify resources needed to support the generation of meaningful RWE for the global PH community.
Current diagnosis and treatment practice for pulmonary hypertension in bronchopulmonary dysplasia—A survey study in Germany (PUsH BPD)
Authors: Häfner Friederike , Johansson Caroline , Schwarzkopf Larissa , Förster Kai , Kraus Yvonne , Flemmer Andreas W. , Hansmann Georg , Sallmon Hannes , Felderhoff‐Müser Ursula , Witt Sabine , Schwettmann Lars , Hilgendorff Anne 
Published: December 2023

AbstractPulmonary hypertension (PH) is the most severe complication in preterm infants with bronchopulmonary dysplasia (BPD) and associated with significant mortality. Diagnostic and treatment strategies, however, still lack standardization. By the use of a survey study (PH in BPD), we assessed clinical practice (diagnosis, treatment, follow‐up) in preterm infants with early postnatal persistent pulmonary hypertension of the newborn (PPHN) as well as at risk for or with established BPD‐associated PH between 06/2018 and 10/2020 in two‐thirds of all German perinatal centers with >70 very low birthweight infants/year including their cardiology departments and outpatient units. Data were analyzed descriptively by measures of locations and distributional shares. In routine postnatal care, clinical presentation and echocardiography were reported as the main diagnostic modalities to screen for PPHN in preterm infants, whereas biomarkers brain natriuretic peptide/N‐terminal pro b‐type natriuretic peptide were infrequently used. For PPHN treatment, inhaled nitric oxide was used in varying frequency. The majority of participants agreed to prescribe diuretics and steroids (systemic/inhaled) for infants at risk for or with established BPD‐associated PH and strongly agreed on recommending respiratory syncytial virus immunization and the use of home monitoring upon discharge. Reported oxygen saturation targets, however, varied in these patients in in‐ and outpatient care. The survey reveals shared practices in diagnostic and therapeutic strategies for preterms with PPHN and BPD‐associated PH in Germany. Future studies are needed to agree on detailed echo parameters and biomarkers to diagnose and monitor disease next to a much‐needed agreement on the use of pulmonary vasodilators, steroids, and diuretics as well as target oxygen saturation levels.
Texture and organic matter associations with soil functional properties in crop and conservation land uses in North Carolina
Authors: Franzluebbers Alan J. 
Published: December 2023

AbstractSoil texture and organic matter are considered overarching factors controlling a diversity of soil processes and properties. However, a more complete understanding of how these factors quantitatively affect other soil properties has been lacking due to either limited scope of land use and management conditions, confounding climate and environmental conditions with management, or narrow range of soil and management conditions. This study evaluated the strength of associations of sand and total soil N concentrations with soil physical, chemical, and biological properties and processes from 310 surface‐soil (0–10‐cm depth) samples (87% Ultisols, 4% Inceptisols, and ≤3% each of Alfisols, Spodosols, Entisols, and Histosols) collected under conventional‐till and no‐till cropland, grassland, and woodland in four physiographic regions of North Carolina. Sand concentration was most strongly associated with dry‐stable mean‐weight diameter (MWD), MWD product, and sieved soil density (|r| > 0.63, p < 0.001). Total soil N concentration was most strongly associated with particulate organic C and N and soil water content at water‐holding capacity (|r| > 0.74, p < 0.001). Soils under unfertilized woodlands deviated the most from general associations, suggesting that organic matter quality could be unique, and requires further investigation. Overall, sand concentration associated more closely with soil physical properties and total soil N concentration associated closely with both soil physical and biogeochemical properties. Soil chemical properties were only weakly associated with either property. This study suggests that soil texture and organic matter would be complementary, additional properties in holistic soil health assessments that already included routine soil chemical analyses.