bluuebunny/crossref_metadata_2025_split huggingface dataset:
We Prevent and Recover as One: Local Responses to Ramp up COVID-19 Vaccination Efforts in the Philippines
Authors: Casimiro Rosemarie , Antonio Olive Chester , Talion Dhick , Ramos Vilma 
Published: November 2023

Abstract
The Philippines is among the pandemic-affected nations globally. The study evaluated COVID-19 vaccination programs in the seven provinces in Region III. The framework for the study was the World Health Organization's Six Building Blocks of Health Systems: Leadership and Governance, Financing, Health Workforce, Information System, Medical Products/Vaccines, and Service Delivery. For implementers, purposeful sampling was used, while for vaccinees, convenience sampling was employed. A self-designed questionnaire, an interview, and focus group discussions (FGD) were used to acquire information from the participants. The mixed sampling design employs both probability random sampling and non-probability sampling to select a sample. The statistics revealed significant variations in the implementation of the COVID-19 vaccination program across the seven provinces of Central Luzon. Identifying practices analyzing reactions to the COVID-19 vaccination distribution are essential components of a successful immunization plan. The findings of this study may aid the government in correcting vaccination misconceptions and deficiencies.
Analysis of Sudan Mpox surveillance data during the recent pandemic, 2022
Authors: Izzoddeen Ahmad , Elbadri Omer , Nageeb Mohammed , Magbol Mustafa 
Published: November 2023

Abstract

Background
Mpox is a zoonosis that is known to be endemic in several Central and West African countries. Recently, in 2022, it has emerged in Europe and the United States, which raises the alarm to be declared in June as a public health event of international concern. This study aimed to analyze Mpox surveillance data at the national level.
Methods
Mpox data was extracted from the disease surveillance line-list at the national level. The data was customized and then analyzed using Epi Info7 software. The analysis was done using frequencies and percentages, and the results were presented in tables and charts. Permission and ethical approval were obtained from the Health Emergency and Epidemic Control Directorate at the Federal Ministry of Health.
Results
From the national line-list 375 records were extracted and analyzed. Males comprised 54.4% of cases. The mean age was 12.90 (SD 14.69), with 50.2% of the cases were children under 15 years old. All cases had a skin rash, and 74.1% reported a fever. Around a third of the cases reported headaches, sore throats, and lymphadenopathy. The majority of the confirmed cases were children under 5 years old. Around half of the cases were either preschool or school children. The states reported 11 cases, with the majority of cases reported from Gadaref, West Darfur, and Khartoum. A history of contact was identified in 5.8% of cases. Specimens were collected for 212 cases, with the disease confirmed in only 18 (4.8%) through RT-PCR. The number of reported cases increased gradually to reach its peak in week 38, with 100 cases reported, and then began to decrease to reach zero cases in late October.
Conclusion
Mpox surveillance is functioning, with suspect cases reported on a daily basis. The infection is more common in males and children. The commonest presentations were rash and fever with a sore throat, and lymphadenopathy was recognized in one-third of cases. The case definition adopted is broad and sensitive to what influenced the specimen’s positivity rate. Carful data collection and complete filling out of the case report form are recommended to have more comprehensive data for analysis.
Establishment of a stem cell administration imaging method in bleomycin- induced pulmonary fibrosis mouse models
Authors: Morita Saho , Iwatake Mayumi , Suga Sakura , Takahashi Kazuomi , Sato Kazuhide , Miyagi-Shiohira Chika , Noguchi Hirofumi , Baba Yoshinobu , Yukawa Hiroshi 
Published: November 2023

Abstract

Pulmonary fibrosis is a progressive disease caused by interstitial inflammation. Treatments are extremely scarce; therapeutic drugs and transplantation therapies are not widely available due to cost and a lack of donors, respectively. Recently, there has been a high interest in regenerative medicine and exponential advancements in stem cell-based therapies have occurred. However, a sensitive imaging technique for investigating thein vivodynamics of transplanted stem cells has not yet been established and the mechanisms of stem cell-based therapy remain largely unexplored. In this study, we administered adipose tissue-derived mesenchymal stem cells (ASCs) labeled with quantum dots (QDs; 8.0 nM) to a mouse model of bleomycin-induced pulmonary fibrosis in an effort to clarify the relationship betweenin vivodynamics and therapeutic efficacy. These QD-labeled ASCs were injected into the trachea of C57BL/6 mice seven days after bleomycin administration to induce fibrosis in the lungs. The therapeutic effects and efficacy were evaluated viain vivo/ex vivoimaging, CT imaging, and H&E staining of lung sections. The QD-labeled ASCs remained in the lungs longer and suppressed fibrosis. The 3D imaging results showed that the transplanted cells accumulated in the peripheral and fibrotic regions of the lungs. These results indicate that ASCs may play a significant role in the therapeutic effects of pulmonary fibrosis. Thus, QD labeling could be a suitable and sensitive imaging technique for evaluatingin vivokinetics in correlation with the efficacy of cell therapy.
D-dimer-based screening for detecting preoperative venous thromboembolism in patients with musculoskeletal tumors: a retrospective study of 756 patients
Authors: Hayashida Kenta , Kawabata Yusuke , Choe Hyonmin , Kato Ikuma , Takeyama Masanobu , Inaba Yutaka 
Published: November 2023

Abstract
Malignant musculoskeletal tumors are considered high risk for venous thromboembolism, but the characteristics of venous thromboembolism in benign musculoskeletal tumors are unclear. We evaluated D-dimer as a screening preoperative test in patients with benign and malignant musculoskeletal tumors to determine the prevalence and risk factors for venous thromboembolism and the utility of D-dimer in the diagnosis of venous thromboembolism. A total of 756 patients, 328 with malignant and 428 with benign, were evaluated for thrombosis by preoperative D-dimer and imaging. Medical data were analyzed retrospectively to determine the prevalence of venous thromboembolism, risk factors and diagnostic accuracy of D-dimer. The prevalence of venous thromboembolism in patients with malignant and benign musculoskeletal tumors was 11.3% and 1.6%, respectively. For malignant tumors, age >60 years, lower extremities, hypertension, and hepatobiliary-pancreatic disease were risk factors for venous thromboembolism, while for benign tumors, pathologic fracture and D-dimer were risk factors for venous thromboembolism. The prevalence of VTE was higher in patients with malignant tumors than in patients with benign tumors, and malignancy was a risk factor for VTE development in musculoskeletal tumors. D-dimer was useful in ruling out VTE in both benign and malignant musculoskeletal tumors, with particularly high diagnostic accuracy in benign tumors.
The Dynamic Instability Analysis of Electrodynamic Tether System
Authors: Li Xialin , Yang Keying , Zhang Jingrui 
Published: November 2023

Abstract

The libration motion of conductive tether in electrodynamic tether system had been demonstrated unstable inherently. This paper conducts a further dynamic analysis of the instability in electrodynamic tether system, specifically investigating the existence of periodic solution and equilibrium point, as well as exploring the condition for rapid instability in libration motion. The dumbbell model is employed to depict the in-plane and out-plane libration motion, and the parameter ε is introduced to incorporate the influences of tether current and inclination. The critical ranges of ε and out-plane angle that determine whether the libration motion will go tumbling quickly are derived analytically based on the existence condition of periodic solution and equilibrium point. The numerical simulations were conducted to demonstrate these analytical critical ranges, and the results show that the libration motion will become unstable quickly if the out-plane angle or ε exceeds the critical range even under control strategy. This critical range of ε and out-plane angle is a general conclusion applicable to any situation (within the limitation of the model considered in this study), which can be utilized in guiding the design of system parameters to avoid rapid instability of electrodynamic tether system.
KMSBOT: Enhancing Educational Institutions with an AI-Powered Semantic Search Engine and Graph Database
Authors: subramanian venkata , J chandra , Ammunuel Ashok , V Rohini 
Published: November 2023

Abstract

In the rapidly evolving field of education, the need for a semantic search engine to efficiently retrieve graph-based data is crucial. Universities and colleges generate vast amounts of educational content research articles, and having a semantic search engine can enhance the accuracy of search results, ensuring that students and staff can access the right information effectively. It's imperative to develop an AI-based smart recommendation system equipped with semantic search capabilities to optimize information retrieval and provide accurate mapping for students or scholars. Such a system can revolutionize how educational content is accessed, offering personalized recommendations that align with the individual learning objectives of students and scholars, thus improving their educational experience. KMSBOT is an innovative academic recommendation system designed to enhance the efficiency of existing models. It effectively summarizes academic data and provides tailored information for students, research scholars, and educational faculty. The system employs a three-module approach, utilizing data structuring, NLP processing, and semantic search engine integration. By leveraging Neo4j, NLTK, and BERT in Python, this proposed work ensures optimal performance metrics such as time, accuracy, and loss value. The proposed solution addresses the limitations of traditional recommendation systems and contributes to improving user satisfaction and engagement in academic environments.
Mendelian Randomization Study Highlights the Role of Haematological Traits on Type-2 Diabetes Mellitus in African Ancestry Individuals
Authors: Fatumo Segun , Soremekun Chisom , Jjingo Daudi , Kateete David , Nashiru Oyekanmi , Nitsch Dorothea , Nyirenda Moffat , Gill Dipender , Zeggini Eleftheria , Grallert Harald , Peters Annette , Chikowore Tinashe , Batini Chiara , Soremekun Opeyemi 
Published: November 2023

Abstract

BackgroundObservational studies have identified associations between haematological traits and type-2 diabetes mellitus (T2D). However, it is difficult to infer causal effects due to the potential of confounding. Our study utilizes the Mendelian randomization (MR) approach to address the above limitation and investigate the causal effect of haematological traits (HT) such as white blood cell (WBC) count, platelet count, haemoglobin (Hb) levels, and red blood cell (RBC) count, on T2D in individuals of African ancestry.MethodsThe participating cohorts included participants of African ancestry in the Blood Cell consortium (n = 15,171) and the Million Veteran Program dataset (N=53,445: Ncases =23,305; Ncontrol = 30,140). We applied a univariable, bidirectional, and multivariable Two-sample MR to estimate the causal relationship between haematological traits and T2D using GWAS summary statistics. Genetic instruments for haematological traits and T2D included only the variants that attained a genome-wide significant level (P ≤ 5 × 10−8) of association with the respective exposure. The inverse-variance weighted MR approach was used in the main analysis, complemented by sensitivity analyses that are more robust to the inclusion of pleiotropic variants, including MR-Egger and MR-PRESSO. We further evaluated the genetic correlation between the hematological traits and T2D using linkage disequilibrium score regression (LDSC).ResultsIn the main inverse-variance weighted (IVW) MR estimates, genetically predicted mean corpuscular hemoglobin concentration (MCHC), mean corpuscular hemoglobin (MCH) and mean corpuscular volume (MCV) levels were associated with decreased risk of T2D. Genetically predicted higher RBC was significantly associated with an increased risk of T2D. For WBC traits, there was evidence of protective effects of total WBC count and neutrophil count (NEU) on T2D. In the reverse analysis, genetically predicted T2D liability was associated with lower levels of RBC distribution width (RDW) and elevated levels of lymphocyte count (LYM). The multivariable analysis supported direct effects of genetically predicted MCH, MCHC, RDW, MCV, and lower levels of WBC with decreased risk of T2D. Additionally, LDSC showed negative genetic correlation of T2D with haematocrit (HCT) and haemoglobin concentration (HGB), and positive with eosinophil (EOS) and platelet count (PLT), suggesting that there is a genetic basis for the association between T2D and these blood traits.ConclusionThese findings indicate that haematological traits may differentially play a role in the development of T2D and be affected by T2D. However, further research is needed to validate and explore the biological pathways and mechanisms involved in these associations.
Synthesis, spectroscopic and structural characterization of two (2,4,6-tribromophenyl)thiourea
Authors: Arslan N. Burcu , Aydın Fatma 
Published: November 2023

Abstract
Two new compounds N-Benzoyl-N'-tribromophenyl thiourea (C14H9Br3N2OS) (I) and 4-Nitrobenzoyl-N'-tribromophenyl thiourea (C14H8Br3N3O3S) (II) were synthesized and characterized by 1HNMR, 13CNMR, IR, and structural (XRD) techniques. The molecular geometry, vibrational frequencies of the title compound (I, II) in the ground state have been calculated by using the density functional theory (DFT) method with B3LYP / 6–311G(d,p) basis set and compared with the experimental data. The calculated results show that the optimized geometries can well reproduce the crystal structural parameters. A detailed vibrational spectral analysis has been carried out and assignments of observed fundamental bands have been proposed on the basis of peak positions. The scaled theoretical frequencies show very good agreement with experimental values. Frontier molecular orbitals energies (HOMO&LUMO), energy gap (ΔE), global chemical reactivity parameters such as ionization potential (IP), electron affinity (ΔE), chemical hardness (η) and chemical softness (σ), etc. have been calculated, the sites of electrophilic and nucleophilic regions where the molecular interactions likely to happen are identified. Besides, molecular electrostatic potential (MEP) and thermodynamic properties of the title compounds were investigated by theoretical calculations.
Plate manufacturing constraint in topology optimization using anisotropic Helmholtz filter
Authors: Wada Yuji , Shimada Tokimasa , Nishiguchi Koji , Okazawa Shigenobu , Tsubokura Makoto 
Published: November 2023

Abstract
The manufacturing constraint of topology optimization for finding structures composed primarily of plate cross sections with an automatically decided surface normal is discussed. The Helmholtz filter to the sensitivity of the objective function is designed such that the eigenvalue-resolved stress tensor is converted to the anisotropic filter tensor. Plate structure formation and stiffness compliance performance are discussed through three sample problems: a solid bar subjected to torsional loads, an L-shaped member subjected to multiple loads, and a vehicle body frame intended to be a complex frame.
Sequencing and analysis of complete plastid genomes of diploid wheats Tritcum sinskajae and Triticum monococcum k-20970
Authors: Azat Kuluev , Bulat Kuluev , Alexey Chemeris 
Published: November 2023

Abstract
Diploid wheat with genome A Triticum sinskajae A. Filat. et Kurk. was discovered in the early 70s. last century during the reproduction of samples of Triticum monococcum L. line k-20970. Despite the fact that T. sinskajae was initially proposed to be identified as a separate wheat species, in further studies it was considered as a spontaneous mutant of T. monococcum. A number of studies have shown that T. sinskajae is genetically different from different T. monococcum lineages, but how different it is from the T. monococcum k-20970 lineage remained unknown. Based on this, the purpose of this study was to sequence and compare the chloroplast genomes of T. sinskajae and T. monococcum line k-20970, as well as to clarify the phylogenetic relationships between diploid wheats based on the results of analysis of the nucleotide sequences of their chloroplast genomes. During this study, we were the first to sequence and annotate the complete chloroplast genomes of T. sinskajae k-48993 (Dagestan), T. monococcum k-20970 (Turkey), T. boeoticum k-58674 (Armenia) on a Genolab M sequencer (GeneMind, China). For comparative analysis, chloroplast genome sequences of T. monococcum subsp. monococcum (LC005977.1) and T. urartu (KJ614411.1) were taken from GenBank. According to the results of the analysis, it turned out that T. sinskajae (k-48993) and T. monococcum k-20970, although they were closer to each other, differed in 10 changes in the chloroplast genome, including 3 substitutions, 1 transversion, 1 deletion, 4 insertions and 4bp inversion of AGAA with TTCT in the rbcL-psal intergenic region. The identified differences in the chloroplast genomes of T. sinskajae (k-48993) and T. monococcum (k-20970) allow us to conclude that they are two very close, but still different species of diploid wheat. A comparison of the chloroplast genomes of diploid wheats showed a common origin of the plasmons of three closely related einkorns - T. sinskajae, T. monococcum and T. boeoticum, while T. urartu is located a little further from them.
Predatory ants are likely to live at a safer distance from termites to capture prey and avoid defensive attacks, a perspective on conflict, coexistence, and neutralism
Authors: Das Pritom , Mahato Sourav , Dolai Avishek , Nayek Sayan , Prusty Arpan , Das Amlan 
Published: November 2023

Abstract

Interactions between insects are an important ecological phenomenon characterised by both cooperation and competition. Ant-termite associations are well-established due to their ubiquity in varied natural environments, nesting grounds, or similar food interests. There exists a predator-prey relationship between the two as the ants are known to predate on termite while the prey, termite may execute ruthless defensive attacks when they build their nest in close proximity to each other and that can be a fatal encounter for both. While this association is a ‘necessary evil’ for termites and ants as they obtain benefits like protection and food from the colonies, both organisms have specific escape routes to ensure maximum benefit transfer with minimum conflict. Under the theory of territorial occupation and area dominance, this study aimed to estimate how close a predatory ant builds its nest to its prey termite colonies to avoid the defensive attacks from the termites in a large area where nesting space is not limited. Despite the significant risk of getting predated, we wondered how close a termite might forage to a predatory ant's nest. In this investigation, we observed the territorial occupation of a predatory ant, Solenopsis geminata (Hymenoptera: Formicidae), and an termite, Odontotermes redemanni (Isoptera: Termitidae), which often coexist in the same landscape. In order to determine the answers, the frequency of ant-nest distributions along a scale from several termite mounds, and the frequency and extent of termite foraging mud-gallery distributions radiating towards ant nests, were measured from ten study mounds dispersed in the study location. Our data suggest that ants S. geminata may avoid O. redemanni mounds to prevent assault. However, they keep a safe distance of atleast 5 to 10 metres (Zone of maximum benefit transfer) while avoiding Zone of conflict (0-5m) and Zone of minimum benefit transfer (0-15m) to increase their chances of catching prey. Our data indicate that both organisms are likely to avoid direct fighting while coexisting in the same ecological zone. The present findings demonstrate how the two natural competitors like ants and termites, frequently in a predator-prey relationship, co-adapt to precision prey capturing while avoiding defensive counter attacks.
Design and Synthesis of Novel Benzoazepinone Derivatives as Potent Estrogen Receptor Alpha Inhibitors
Authors: Venugopal N.V.S. , Nizampatnam  , Jagadeesh S. Tirumala 
Published: November 2023

Abstract
Background
Selective estrogen receptor modulators (SERMs) block the effects of estrogen on breast cancer cells by sitting in the estrogen receptors. If a SERM is in the estrogen receptor, estrogen can't attach to the cancer cell and the cell doesn't receive estrogen's signals to grow and multiply. The goal of this research is to develop small drug-like molecules of novel Benzoazepinone derivatives that mimic the ability of the SERM (Tamoxifene and Raloxifene) to binds with estrogen receptor protein.
Methods
2-Phenylethyl bromide undergoes amino alkylation through mannich reaction with CH3NH2 and chloro acetyl chloride, gives 2-chloro-N-methyl-N-phenethylacetamide, which is further undergoing cyclization gives 3-methyl-1,3,4,5-tetrahydro-2H-benzo[d]azepin-2-one.2-phenylethyl bromide. 1-amino-3-methyl-1,3,4,5-tetrahydro-2H-benzo[d]azepin-2-one.di-p-toluoyl-1-tartaric acid and 1-amino-3-methyl-1,3,4,5-tetrahydro-2H-benzo[d]azepin-2-one. HCl was obtained by treatment with di-p-toluoyl-l-tartaric acid and con. HCl respectively. Finally, this intermediate undergoes nucleophilic addition reactions with different substituted aldehydes. All the compounds were screened for their in-vitro cytotoxicity activity using Vero and MDA MB 231 cell lines by MTT assay.
Results
IC50 values from Cytotoxicity studies by MTT assay ranges from 11µg/ml to 153µg/ml. A total of 15 compounds were synthesized by using a diverse scheme and the title compounds have exhibited low to high in-vitro anticancer activity with MDA MB 231 cells. Compared to the standard (Raloxifene 6 µg/ml), the developed compounds T2 (35µg/ml), T10 (36µg/ml), T14 (11µg/ml) and T15 (22 µg/ml).
Conclusion
Finally, four compounds might be used as a lead molecule for future development into a therapeutically viable anti-ER positive breast cancer drug from the benzoazepinone derivatives family.