bluuebunny/crossref_metadata_2025_split huggingface dataset:
Heart rate variability and risk of agitation in Alzheimer’s disease: the Atherosclerosis Risk in Communities Study
Authors: Liu Kathy Y , Whitsel Eric A , Heiss Gerardo , Palta Priya , Reeves Suzanne , Lin Feng V , Mather Mara , Roiser Jonathan P , Howard Robert 
Published: October 2023

Abstract
Agitation in Alzheimer’s disease is common and may be related to impaired emotion regulation capacity. Heart rate variability, a proposed index of autonomic and emotion regulation neural network integrity, could be associated with agitation propensity in Alzheimer’s disease. We used the Atherosclerosis Risk in Communities Study cohort data, collected over seven visits spanning over two decades, to investigate whether heart rate variability (change) was associated with agitation risk in individuals clinically diagnosed with dementia due to Alzheimer’s disease. Agitation (absence/presence) at Visit 5, the primary outcome, was based on the Neuropsychiatric Inventory agitation/aggression subscale, or a composite score comprising the total number of agitation/aggression, irritability, disinhibition and aberrant motor behaviour subscales present. Visit 1–5 heart rate variability measures were the log-transformed root mean square of successive differences in R–R intervals and standard deviation of normal-to-normal R–R intervals obtained from resting, supine, standard 12-lead ECGs. To aid interpretability, heart rate variability data were scaled such that model outputs were expressed for each 0.05 log-unit change in heart rate variability (which approximated to the observed difference in heart rate variability with every 5 years of age). Among 456 participants who had dementia, 120 were clinically classified to have dementia solely attributable to Alzheimer’s disease. This group showed a positive relationship between heart rate variability and agitation risk in regression models, which was strongest for measures of (potentially vagally mediated) heart rate variability change over the preceding two decades. Here, a 0.05 log-unit of heart rate variability change was associated with an up to 10-fold increase in the odds of agitation and around a half-unit increase in the composite agitation score. Associations persisted after controlling for participants’ cognitive status, heart rate (change), sociodemographic factors, co-morbidities and medications with autonomic effects. Further confirmatory studies, incorporating measures of emotion regulation, are needed to support heart rate variability indices as potential agitation propensity markers in Alzheimer’s disease and to explore underlying mechanisms as targets for treatment development.
Plasma levels of mannan-binding lectin-associated serine proteases are increased in type 1 diabetes patients with insulin resistance
Authors: Kietsiriroje Noppadol , Scott Georgia E , Ajjan Ramzi A , Brôz Jan , Schroeder Verena , Campbell Matthew D 
Published: October 2023

Abstract
Activation of the lectin pathway of the complement system, as demonstrated by elevated levels of mannan-binding lectin proteins (MBL), contributes to vascular pathology in type 1 diabetes (T1D). Vascular complications are greatest in T1D individuals with concomitant insulin resistance (IR), however, whether IR amplifies activiation of the lectin pathway in T1D is unknown. We pooled pretreatment data from two RCTs and performed a cross-sectional analysis on 46 T1D individuals. We employed estimated glucose disposal rate (eGDR), a validated IR surrogate with cut-points of: &lt;5.1, 5.1–8.7, and &gt; 8.7 mg/kg/min to determine IR status, with lower eGDR values conferring higher degrees of IR. Plasma levels of MBL-associated proteases (MASP-1, MASP-2, and MASP-3) and their regulatory protein MAp44 were compared among eGDR classifications. In a subset of 14 individuals, we assessed change in MASPs and MAp44 following improvement in IR. We found that MASP-1, MASP-2, MASP-3, and MAp44 levels increased in a stepwise fashion across eGDR thresholds with elevated MASPs and MAp44 levels conferring greater degrees of IR. In a subset of 14 patients, improvement in IR was associated with significant reductions in MASPs, but not MAp44, levels. In conclusion, IR in T1D amplifies levels of MASP-1/2/3 and their regulator MAp44, and improvement of IR normalizes MASP-1/2/3 levels. Given that elevated levels of these proteins contribute to vascular pathology, amplification of the lectin pathway of the complement system may offer mechanistic insight into the relationship between IR and vascular complications in T1D.
Political aspects of ‘buffer stock’ employment: a reconsideration
Authors: Setterfield Mark , Kriesler Peter , Halevi Joseph 
Published: October 2023

AbstractAdvocates of Job Guarantee (JG) or Employer of Last Resort (ELR) schemes have suggested that if the state provides ‘buffer stock’ employment to workers displaced from private employment, then full employment can be maintained over the course of the business cycle. Kalecki was sceptical about the prospects for maintaining full employment in capitalist economies, without fundamental institutional change that would alleviate certain political constraints. We argue that in and of themselves, JG/ELR schemes do not create the fundamental institutional change required to address Kalecki’s concerns and so ensure that full employment becomes achievable as a permanent state.
Structure optimization of pulsed electric field processor and its sterilization effect
Authors: Tian Ye , Fan Wenshuo , Lu Weijian , Zhang Guanjun , Chang Zhengshi 
Published: October 2023

Abstract
Pulsed electric field (PEF) technology is a highly promising non-thermal processing technique, which holds great potential for sterilizing liquid food. The effectiveness of this treatment depends on two crucial factors: pulse parameters and the structure of the processor. In this study, we focus on optimizing the shape of insulators within the PEF processor to improve the sterilization effect. This research provides a reliable technical reference for designing industrial equipment. The numerical simulation of multi-physics fields was employed to analyze the temperature, electric field, and fluid field distributions for different insulators. Ultimately, the geometric structure of the insulator was optimized by embedding a 0.7-mm arc. Sterilization experiments were then conducted on Escherichia coli and Staphylococcus aureus suspensions with conductivities similar to those of real grapefruit juice. The sterilization effect of the processor with the optimized structure and the maximum applied voltage was examined at the same driving frequency. The results indicate that compared to the original structure, there is an increase in withstanding voltage by 5–10 kV while maintaining significantly improved bactericidal effects at the same applied voltage. Furthermore, we preliminarily discussed the sterilization mechanism by combining electroporation theory with the electroporation threshold of S. aureus.
A Reappraisal of the Effects of L-type Ca2+ Channel Blockers on Store-Operated Ca2+ Entry and Heart Failure
Authors: Bird Gary S , D’Agostin Diane , Alsanosi Safaa , Lip Stefanie , Padmanabhan Sandosh , Parekh Anant B 
Published: October 2023

Abstract
Dihydropyridines such as amlodipine are widely used as antihypertensive agents, being prescribed to ∼70 million Americans and &gt;0.4 billion adults worldwide. Dihydropyridines block voltage-gated Ca2+ channels in resistance vessels, leading to vasodilation and a reduction in blood pressure. Various meta-analyses show that dihydropyridines are relatively safe and effective in reducing hypertension. The use of dihydropyridines has recently been called into question as these drugs appear to activate store-operated Ca2+ entry in fura-2-loaded nonexcitable cells, trigger vascular remodeling, and increase heart failure, leading to the questioning of their clinical use. Given that hypertension is the dominant “silent killer” across the globe affecting ∼1.13 billion people, removal of Ca2+ channel blockers as antihypertensive agents has major health implications. Here, we show that amlodipine has marked intrinsic fluorescence, which further increases considerably inside cells over an identical excitation spectrum as fura-2, confounding the ability to measure cytosolic Ca2+. Using longer wavelength Ca2+ indicators, we find that concentrations of Ca2+ channel blockers that match therapeutic levels in serum of patients do not activate store-operated Ca2+ entry. Antihypertensive Ca2+ channel blockers at pharmacological concentrations either have no effect on store-operated channels, activate them indirectly through store depletion or inhibit the channels. Importantly, a meta-analysis of published clinical trials and a prospective real-world analysis of patients prescribed single antihypertensive agents for 6 mo and followed up 1 yr later both show that dihydropyridines are not associated with increased heart failure or other cardiovascular disorders. Removal of dihydropyridines for treatment of hypertension cannot therefore be recommended.
Endoscopic ultrasound-guided injection of carbon nanoparticles suspension to label rectal cancer before neoadjuvant chemoradiotherapy: a retrospective cohort study
Authors: Lin Nan , Wang Yuanzhao , Yu Changwei , Wu Weihang , Fang Yongchao , Yang Jin , Liu Wangwu , Wang Rong , Jiang Yanyan , Wang Yu 
Published: October 2023

Abstract

Background
Localization of the primary tumor and ensuring safe distal surgical margins (DSMs) following neoadjuvant chemoradiotherapy (nCRT) are challenging in locally advanced rectal cancers (LARCs). This study investigated the effectiveness of carbon nanoparticles suspension (CNS) for labeling the primary tumor and allowing precise tumor resection after nCRT.

Methods
Clinicopathological data of LARC patients who underwent nCRT followed by laparoscopic radical anal preservation surgery at our center between January 2018 and February 2023 were prospectively collected. The patients were divided into the CNS tattooed (CNS) and non-tattooed (control) groups. In the CNS group, CNS was injected in four quadrants on the anal side 1 cm away from the lower tumor margin. DSMs were determined through intraoperative distal rectal examination in the control group and observation of CNS tattoos in the CNS group. DSM lengths and positive DSM rates were compared between the two groups to analyse the feasibility and effectiveness of CNS for labeling LARCs before nCRT.

Results
There was no statistically significant difference in the basic demographic data, effectiveness of nCRT, or post-operative recovery rates between the two groups (all P &gt; 0.05). In the CNS group, CNS tattoos were observed on the outside of the rectal wall, with an overall efficiency of 87.1% (27/31). The CNS group had fewer positive DSMs and safer DSM lengths (2.73 ± 0.88 vs 2.12 ± 1.15 cm, P = 0.012) than the control group (P &lt; 0.05).

Conclusions
Endoscopic ultrasound-guided injection of CNS tattoos before nCRT could effectively label the LARCs, ensuring safe DSMs during anus-preserving surgeries (Chictr.org.cn No.: ChiCTR2300068991).
The role of theory in researching and understanding human communication
Authors: Levine Timothy R , Markowitz David M 
Published: October 2023

Abstract
Communication is a theory-driven discipline, but does it always need to be? This article raises questions related to the role of theory in communication science, with the goal of providing a thoughtful discussion about what theory is, why theory is (or is not) important, the role of exploration in theory development, what constitutes a theoretical contribution, and the current state of theory in the field. We describe communication researchers’ interest with theory by assessing the number of articles in the past decade of research that mention theory (nearly 80% of papers have attended to theory in some way). This article concludes with a forward-looking view of how scholars might think about theory in their work, why exploratory research should be valued more and not considered as conflicting with theory, and how conceptual clarity related to theoretical interests and contributions are imperative for human communication research.
Real-time multi-month forecasting of skipjack tuna (Katsuwonus pelamis) habitat in the western and central Pacific Ocean for improved fishing efficiency and fisheries management
Authors: Wu X H , Chang Y , Liao T Y , Ding M M , Ke C C 
Published: October 2023

Abstract
Marine fish experience shifts in their distribution due to changes in the physical and biological environments. These shifts pose challenges for fishery businesses and management in international fisheries organizations. In the western and central Pacific Ocean, changes in the spatial distribution of skipjack tuna (Katsuwonus pelamis) due to climate variability often influence fishing activities and economic benefits. This study provides an operational forecast to enhance the decision-making process for fishery managers and fishermen by informing them about fish distributions in the coming months. Monthly forecasts of skipjack tuna habitat are generated utilizing a species distribution model (boosted regression trees) in combination with real-time environmental forecasts. An alternative method (dynamic time warping) is proposed to improve monthly chlorophyll forecasts, which are crucial for enhancing skipjack tuna habitat forecasting. To assess the prediction skills of the model, a retrospective analysis was conducted, forecasting skipjack tuna distribution over 9-month periods and comparing the forecasts with observed occurrences. The results demonstrate that 67.9% of the observed skipjack tuna catches occurred within the forecasted habitats, indicating that the forecast model skillfully predicted skipjack tuna movements 9 months in advance. These monthly updated forecasts can serve as a potential tool for resource managers in developing effective management strategies and fishers in planning fishing operations sustainably and responsibly.
What Is Needed to Move Toward Single-Step Diagnosis of Current HCV Infection?
Authors: Feld Jordan J 
Published: October 2023

Abstract
Despite remarkable therapeutic advances, hepatitis C virus (HCV) infection continues to be a major global problem. While the development of highly effective direct-acting antivirals has ensured that almost all those who are treated achieve viral cure, progress toward HCV elimination globally has stalled due to challenges upstream of treatment in the cascade of care, namely diagnosis and linkage to care. The major challenge continues to be the relative complexity of HCV diagnosis with the current requirement for a confirmatory HCV RNA test after an initial antibody-positive result. In this review, challenges with the current paradigm are highlighted with a focus on new technologies, as well as simple strategies using existing tools, which may simplify diagnosis and improve linkage to care and treatment. To achieve HCV elimination, improvements in the HCV diagnostics field to allow for a simple single-step diagnosis are required.
Insights into molecular mechanism of plasticizer biodegradation in Dietzia kunjamensis IITR165 and Brucella intermedia IITR166 isolated from a solid waste dumpsite
Authors: Singh Saurabh , Thakur Ravindra Singh , Manickam Natesan 
Published: October 2023

Abstract

Aims
Isolation of phthalate esters (PAEs) degrading bacteria from a solid waste dumpsite could degrade many plasticizers efficiently and to investigate their degrading kinetics, pathways, and genes.

Methods and results
Based on their 16S rRNA gene sequence the strains were identified as Dietzia kunjamensis IITR165 and Brucella intermedia IITR166, which showed a first-order degradation kinetic model under lab conditions. The quantification of phthalates and their intermediate metabolites identification were done by using ultra-high-performance liquid chromatography (UHPLC) and gas chromatography-tandem mass-spectrometry (GC-MS/MS), respectively. Both the bacteria utilized &gt;99% dibutyl phthalate at a high concentration of 100-400 mg L−1 within 192 h as monitored by UHPLC. GC-MS/MS revealed the presence of metabolites dimethyl phthalate (DMP), phthalic acid (PA), and benzoic acid (BA) during DBP degradation by IITR165 while monobutyl phthalate (MBP) and PA were identified in IITR166. Phthalate esters degrading gene cluster in IITR165 comprised two novel genes coding for carboxylesterase (dkca1) and mono-alkyl phthalate hydrolase (maph), having only 37.47% and 47.74% homology, respectively, with reported phthalate degradation genes, along with the terephthalate dioxygenase system (tphA1, A2, A3, and B). However, IITR166 harbored different gene clusters comprising di-alkyl phthalate hydrolase (dph_bi), and phthalate dioxygenase (ophA, B, and C) genes.

Conclusions
Two novel bacterial strains, Dietzia kunjamensis IITR165 and Brucella intermedia IITR166, were isolated and found to efficiently degrade DBP at high concentrations. The degradation followed first-order kinetics, and both strains exhibited a removal efficiency of over 99%. Metabolite analysis revealed that both bacteria utilized de-methylation, de-esterification, and decarboxylation steps during degradation.
Disparities in outcomes and access to therapy options in hepatocellular carcinoma
Authors: Beltrán Ponce Sara , Gokun Yevgeniya , Douglass Francisca , Dawson Laura , Miller Eric , Thomas Charles R , Pitter Kenneth , Conteh Lanla , Diaz Dayssy A 
Published: October 2023

Abstract

Background
Hepatocellular carcinoma (HCC) disproportionately impacts racial and ethnic minorities and patients with lower socioeconomic status. These social determinants of health (SDH) lead to disparities in access to care and outcomes. We aim to understand the relationship between SDH and survival and locoregional treatment options in HCC.

Methods
Using the National Cancer Database, we evaluated survival and access locoregional treatments including non-transplant surgery, liver transplant (LT), and liver-directed radiation therapy (LDRT) in patients with HCC diagnosed between 2004 and 2017. Variables including clinical stage, age, sex, race, income, rurality, year of diagnosis, facility type (FT), Charlson-Deyo score (CD), and insurance were evaluated. Cox proportional hazards multivariable regression and dominance analyses were used for analyses.

Results
In total, 140 340 patients were included. Worse survival was seen with advanced stage, older age, Black race, rurality, public insurance, treatment at a nonacademic center, and lower income. The top predictors for survival included stage, age, and income. Completion of non-transplant surgery was best predicted by stage, FT, and insurance type, whereas LT was predicted by age, year of diagnosis, and CD score. LDRT utilization was most associated with year of diagnosis, FT, and CD score.

Conclusion
For patients with HCC, survival was predicted primarily by stage, age, and income. The primary sociodemographic factors associated with access to surgical treatments, in addition to FT, were insurance and income, highlighting the financial burdens of health care. Work is needed to address disparities in access to care, including improved insurance access, addressing financial inequities and financial toxicities of treatments, and equalizing care opportunities in community centers.
Iatrogenic tracheal laceration due to rigid bronchoscopy treated by endoscopic stent placement: a case report
Authors: Motono Nozomu , Mizoguchi Takaki , Ishikawa Mashahito , Iwai Shun , Iijima Yoshihito , Uramoto Hidetaka 
Published: October 2023

Abstract
Although rigid bronchoscopy may lead to tracheal injury, the incidence is unknown. A 59-year-old woman diagnosed with clinical stage IV esophageal cancer was scheduled to undergo placement of a silicon Y-stent by rigid bronchoscopy to address tracheal stenosis. When the tumor was cored out by rigid bronchoscopy, perforation of the lower trachea occurred, and a silicon Y-stent was inserted to cover the tracheal fistula. Chest X-ray revealed right pneumothorax, and chest drainage was performed. When spontaneous ventilation was confirmed, the patient was weaned from the ventilator in the operating room. Chest computed tomography immediately after surgery showed an air space on the right side of the stent. The space gradually disappeared over time, and no air leakage was observed. The chest drain was removed on postoperative Day 12. Conservative treatment using a silicon Y-stent for iatrogenic tracheal injury due to rigid bronchoscopy is safe.
UV-continuum β slopes of individual z ∼ 2–6 clumps and their evolution
Authors: Bolamperti A , Zanella A , Meštrić U , Vanzella E , Castellano M , Bergamini P , Calura F , Grillo C , Meneghetti M , Mercurio A , Rosati P , Devereaux T , Iani E , Vernet J 
Published: October 2023

ABSTRACT
We study the ultraviolet (UV) continuum β slope of a sample of 166 clumps, individual star-forming regions observed in high-redshift galaxies. They are hosted by 67 galaxies with redshift between 2 and 6.2, strongly lensed by the Hubble Frontier Fields cluster of galaxies MACS J0416.1 − 2403. The β slope is sensitive to a variety of physical properties, such as the metallicity, the age of the stellar population, the dust attenuation throughout the galaxy, the stellar initial mass function (IMF), and the star formation history (SFH). The aim of this study is to compare the β-values of individual clumps with those measured on the entire galaxy, to investigate possible physical differences between these regions and their hosts. We found a median value of β ∼ −2.4, lower than that of integrated galaxies. This result confirms that clumps are sites of intense star formation, populated by young, massive stars, whose spectrum strongly emits in the UV. This is also consistent with the assumption that the dust extinction at the location of the clumps is lower than the average extinction of the galaxy, or that clumps have a different IMF or SFH. We made use of the correlations, discovered for high-redshift galaxies, of the β-value with those of redshift and UV magnitude, MUV, finding that clumps follow the same relations, extended to much fainter magnitudes (MUV &lt; −13). We also find evidence of eight clumps with extremely blue (β ≲ −2.7) slopes, which could be the signpost of low-metallicity stars and constrain the emissivity of ionizing photons at high redshift.
Effect of temperature on measurement of fundamental constants using white dwarfs in Gaia-EDR3 survey
Authors: Uniyal Akhil , Kalita Surajit , Chakrabarti Sayan 
Published: October 2023

ABSTRACT
Fundamental constants are crucial for comprehending physical mechanisms, but their measurements contain uncertainties due to experimental limitations. We investigate the impact of system temperature on these uncertainties using nearby white dwarfs observed in the Gaia Early Data Release 3 (EDR3) survey. Using the structures of these white dwarfs, we show that the variation in system temperature can affect the accuracy of measurements for fundamental parameters such as the fine-structure constant and the proton-to-electron mass ratio. This exploration emphasizes the importance of considering the energy of a system while putting bounds on the values of fundamental constants.