bluuebunny/crossref_metadata_2025_split huggingface dataset:
L. Lacchè, L'espropriazione per pubblica utilità, Amministratori e proprietari nella Francia dell'Ottocento. [Università di Macerata, Pubblicazioni della Facoltà di Giurisprudenza, Seconda serie, 82]. Giuffrè, Milano 1995. XXXI + 705 p.
Authors: Waelkens  
Published: November 2003

AbstractNo Abstract
A. Sanguinetti, Dalla querela alla portio legitima, Aspetti della successione necessaria nell'epoca tardo imperiale e giustinianea. [Pubblicazioni della Facoltà di Giurisprudenza, Dipartimento di scienze giuridiche, Università di Modena, nuova serie, 36]. Giuffrè, Milano 1996. 162 p.
Authors: Tellegen  
Published: November 2003

AbstractNo Abstract
G.P. Alders, J.G. Kruisheer, A. Schweitzer [en] J. van Venetiën, Het ontstaan van Beverwijk als stedelijke nederzetting, Met een editie van de stadskeur van 11 november 1298 (Latijnse tekst en vertaling in het Nederlands). Verloren, Hilversum 1998. 72 p.
Authors: de Boer  
Published: November 2003

AbstractNo Abstract
D. Strauch, Kleine rechtsgeschichtliche Schriften: Aufsätze 1965-1997, Aus Anlass seines 65. Geburtstages herausgegeben von M. Baldus und H.P. Neuheuser. [Rheinischer Verein für Rechtsgeschichte e.V., Rechtsgeschichtliche Schriften, 11]. Böhlau, Köln-Weimar-Wien 1998. XI + 445 S. m. Titelporträt
Authors: Moorman van Kappen  
Published: November 2003

AbstractNo Abstract
K. Akashi, Cornelius van Bijnkershoek: his Role in the History of International Law. [International Law in Japanese Perspective, 4]. Kluwer Law International, The Hague-London-Boston [1998]. XII + 199 p. [Revised version of a thesis defended in the University of Utrecht 1996]
Authors: van den Bergh  
Published: November 2003

AbstractNo Abstract
Gisela Jung, Die zivilrechtliche Stellung der Frau im Grossherzogtum Hessen, Über die Geschlechtsvormundschaft im 19. Jahrhundert. [Quellen und Forschungen zur hessischen Geschichte, 112]. Selbstverlag der Hessischen Historischen Kommission Darmstadt und der Historischen Kommission für Hessen, Darmstadt und Marburg 1997. 402 S. und eine Karte
Authors: Schubert  
Published: November 2003

AbstractNo Abstract
Berichtigungsliste der Griechischen Papyrusurkunden aus Ägypten, Bd. 10, hrsg. von P.W. Pestman und H.-A. Rupprecht, zusammengestellt von A.M.F.W. Verhoogt, F.A.J. Hoogendijk [und] N. Kruit. Brill, Leiden-Boston-Köln 1998. X + 351 S.
Authors: Hengstl  
Published: November 2003

AbstractNo Abstract
Cost-Effectiveness of Whole-Genome vs Whole-Exome Sequencing Among Children With Suspected Genetic Disorders
Authors: Nurchis Mario Cesare , Radio Francesca Clementina , Salmasi Luca , Heidar Alizadeh Aurora , Raspolini Gian Marco , Altamura Gerardo , Tartaglia Marco , Dallapiccola Bruno , Pizzo Elena , Gianino Maria Michela , Damiani Gianfranco 
Published: January 2024

ImportanceThe diagnosis of rare diseases and other genetic conditions can be daunting due to vague or poorly defined clinical features that are not recognized even by experienced clinicians. Next-generation sequencing technologies, such as whole-genome sequencing (WGS) and whole-exome sequencing (WES), have greatly enhanced the diagnosis of genetic diseases by expanding the ability to sequence a large part of the genome, rendering a cost-effectiveness comparison between them necessary.ObjectiveTo assess the cost-effectiveness of WGS compared with WES and conventional testing in children with suspected genetic disorders.Design, Setting, and ParticipantsIn this economic evaluation, a bayesian Markov model was implemented from January 1 to June 30, 2023. The model was developed using data from a cohort of 870 pediatric patients with suspected genetic disorders who were enrolled and underwent testing in the Ospedale Pediatrico Bambino Gesù, Rome, Italy, from January 1, 2015, to December 31, 2022. The robustness of the model was assessed through probabilistic sensitivity analysis and value of information analysis.Main Outcomes and MeasuresOverall costs, number of definitive diagnoses, and incremental cost-effectiveness ratios per diagnosis were measured. The cost-effectiveness analyses involved 4 comparisons: first-tier WGS with standard of care; first-tier WGS with first-tier WES; first-tier WGS with second-tier WES; and first-tier WGS with second-tier WGS.ResultsThe ages of the 870 participants ranged from 0 to 18 years (539 [62%] girls). The results of the analysis suggested that adopting WGS as a first-tier strategy would be cost-effective compared with all other explored options. For all threshold levels above €29 800 (US $32 408) per diagnosis that were tested up to €50 000 (US $54 375) per diagnosis, first-line WGS vs second-line WES strategy (ie, 54.6%) had the highest probability of being cost-effective, followed by first-line vs second-line WGS (ie, 54.3%), first-line WGS vs the standard of care alternative (ie, 53.2%), and first-line WGS vs first-line WES (ie, 51.1%). Based on sensitivity analyses, these estimates remained robust to assumptions and parameter uncertainty.Conclusions and RelevanceThe findings of this economic evaluation encourage the development of policy changes at various levels (ie, macro, meso, and micro) of international health systems to ensure an efficient adoption of WGS in clinical practice and its equitable access.
Structural Racism, Mass Incarceration, and Racial and Ethnic Disparities in Severe Maternal Morbidity
Authors: Hailu Elleni M. , Riddell Corinne A. , Bradshaw Patrick T. , Ahern Jennifer , Carmichael Suzan L. , Mujahid Mahasin S. 
Published: January 2024

ImportanceRacial and ethnic inequities in the criminal-legal system are an important manifestation of structural racism. However, how these inequities may influence the risk of severe maternal morbidity (SMM) and its persistent racial and ethnic disparities remains underinvestigated.ObjectiveTo examine the association between county-level inequity in jail incarceration rates comparing Black and White individuals and SMM risk in California.Design, Setting, and ParticipantsThis population-based cross-sectional study used state-wide data from California on all live hospital births at 20 weeks of gestation or later from January 1, 1997, to December 31, 2018. Data were obtained from hospital discharge and vital statistics records, which were linked with publicly available county-level data. Data analysis was performed from January 2022 to February 2023.ExposureJail incarceration inequity was determined from the ratio of jail incarceration rates of Black individuals to those of White individuals and was categorized as tertile 1 (low), tertile 2 (moderate), tertile 3 (high), with mean cutoffs across all years of 0 to 2.99, 3.00 to 5.22, and greater than 5.22, respectively.Main Outcome and MeasuresThis study used race- and ethnicity-stratified mixed-effects logistic regression models with birthing people nested within counties and adjusted for individual- and county-level characteristics to estimate the odds of non–blood transfusion SMM (NT SMM) and SMM including blood transfusion–only cases (SMM; as defined by the Centers for Disease Control and Prevention SMM index) associated with tertiles of incarceration inequity.ResultsThis study included 10 200 692 births (0.4% American Indian or Alaska Native, 13.4% Asian or Pacific Islander, 5.8% Black, 50.8% Hispanic or Latinx, 29.6% White, and 0.1% multiracial or other [individuals who self-identified with ≥2 racial groups and those who self-identified as “other” race or ethnicity]). In fully adjusted models, residing in counties with high jail incarceration inequity (tertile 3) was associated with higher odds of SMM for Black (odds ratio [OR], 1.14; 95% CI, 1.01-1.29 for NT SMM; OR, 1.20, 95% CI, 1.01-1.42 for SMM), Hispanic or Latinx (OR, 1.24; 95% CI, 1.14-1.34 for NT SMM; OR, 1.20; 95% CI, 1.14-1.27 for SMM), and White (OR, 1.02; 95% CI, 0.93-1.12 for NT SMM; OR, 1.09; 95% CI, 1.02-1.17 for SMM) birthing people, compared with residing in counties with low inequity (tertile 1).Conclusions and RelevanceThe findings of this study highlight the adverse maternal health consequences of structural racism manifesting via the criminal-legal system and underscore the need for community-based alternatives to inequitable punitive practices.
An Activatable Dual Polymer Nanosystem for Photoimmunotherapy and Metabolic Modulation of Deep‐Seated Tumors
Authors: Liu Gengqi , Li Jiexin , Wang Xiaojie , Ren He , Zhang Yumiao 
Published: January 2024

AbstractNanomedicine in combination with immunotherapy has shown great potential in the cancer treatment, but phototherapeutic nanomaterials that specifically activate the immunopharmacological effects in deep tumors have rarely been developed due to limited laser penetration depth and tumor immune microenvironment. Herein, this work reports a newly synthesized semiconducting polymer (SP) grafted with imiquimod R837 and indoxmid encapsulated micelle (SPRIN‐micelle) with strong absorption in the second near infrared window (NIR‐II) that can relieve tumor immunosuppression and enhance the photothermal immunotherapy and catabolic modulation on tumors. Immune agonists (Imiquimod R837) and immunometabolic modulators (indoxmid) are covalently attached to NIR‐II SP sensors via a glutathione (GSH) responsive self‐immolation linker and then loaded into Pluronic F127 (F127) micelles by a temperature‐sensitive critical micelle concentration (CMC)‐switching method. Using this method, photothermal effect of SPRIN‐micelles in deep‐seated tumors can be activated, leading to effective tumor ablation and immunogenic cell death (ICD). Meanwhile, imiquimod and indoxmid are tracelessly released in response to the tumor microenvironment, resulting in dendritic cell (DC) maturation by imiquimod R837 and inhibition of both indoleamine 2,3‐dioxygenase (IDO) activity and Treg cell expression by indoxmid. Ultimately, cytotoxic T‐lymphocyte infiltration and tumor metastasis inhibition in deep solid tumors (9 mm) are achieved. In summary, this work demonstrates a new strategy for the combination of photothermal immunotherapy and metabolic modulation by developing a dual functional polymer system including activable SP and temperature‐sensitive F127 for the treatment of deep solid tumors.
Enabling Self‐Adaptive Water‐Energy‐Balance of Photothermal Water Diode Evaporator: Dynamically Maximizing Energy Utilization Under the Ever‐Changing Sunlight
Authors: Wei Dan , Wang Chengbing , Shi Guoliang , Zhang Jing , Wang Fan , Tan Puxin , Zhao Zexiang , Xie Yunong 
Published: January 2024

AbstractMaintaining a match between input solar energy and required energy by water supply management is key to achieving efficient interfacial solar‐driven evaporation (ISDE). In practice, the solar radiation flux is constantly changing throughout the day, so keeping a dynamic water‐energy‐balance of ISDE is a big challenge. Herein, a photothermal water diode (WD) evaporator concept is proposed by an integrated hydrophilic/hydrophobic Janus absorber to overcome the issue. Due to the unique unidirectional water transport properties induced by asymmetric wettability, a self‐adaptive balance between photothermal energy input and water uptake is established, thus realizing the energy matching and utilization maximization. The experimental and simulation results exhibit that with the increase of sunlight intensity, the water supply speed is significantly accelerated due to the dynamic management and self‐regulation on water replenishment. Therefore, an excellent evaporation rate of up to 2.14 kg m–2 h–1 with a high efficiency of 93.7% under 1 sun illumination is achieved. This water diode engineering with Janus wettability provides a novel strategy and extends the path for designing solar evaporation systems with diverse water supply properties, which shows great potential in different environmental conditions.
Meta‐Structured Covalent Organic Framework Nanocoatings with Active and Angle‐Independent Structural Coloration
Authors: Jiang Yanqiu , Chen Di , Zhang Ziyang , Wu Xubing , Tu Yinuo , Zheng Zhenqian , Mao Linjie , Li Wei , Ma Yuting , Yang Xuan , Wang Wen‐Jun , Liu Pingwei 
Published: January 2024

AbstractHigh‐performance multifunctional nanocoatings not only protect and enhance substrate materials but also offer additional functionalities. This demands a sophisticated coordination of the coating's inherent properties and microstructural features. Here, a multifunctional active nanocoating via meta‐structural engineering of covalent organic framework (COF) deposition materials is presented. This COF nanocoating, characterized by well‐defined micropores (1–2 nm), meta‐structured textures (30–300 nm), tailored thickness (100–300 nm), and good uniformness, showcases a unique combination of angle‐independent structural coloration and ultrafast responsiveness to gaseous stimuli. Remarkably, it demonstrates good compatibility with a wide range of inert substrate materials, from rigid ones like glass and metal to flexible elastomers and nanomaterial films of various shapes and sizes. This versatility enables the facile development of devices that can optically report information about their environments. Examples include chemically active coatings with ultrafast (≈10 ms) color‐changing behaviors and programmable actuation behaviors upon exposure to gaseous stimuli, and mechanically active coatings that can detect substrate strain up to 50% yet maintain structural robustness and consistent coloration hue. It is believed that meta‐structural engineering of COF nanocoatings on inert substrates can enable them to respond to environmental stimuli, potentially indicating a new trend in developing multifunctional materials and smart devices.
Microalgae‐Based Hydrogel for Inflammatory Bowel Disease and Its Associated Anxiety and Depression
Authors: Zhong Danni , Jin Kangyu , Wang Ruoxi , Chen Bing , Zhang Jinghui , Ren Chaojie , Chen Xiaoyuan , Lu Jing , Zhou Min 
Published: January 2024

AbstractPatients diagnosed with inflammatory bowel disease (IBD) exhibit a notable prevalence of psychiatric disorders, such as anxiety and depression. Nevertheless, the etiology of psychiatric disorders associated with IBD remains uncertain, and an efficacious treatment approach has yet to be established. Herein, an oral hydrogel strategy (SP@Rh‐gel) is proposed for co‐delivery of Spirulina platensis and rhein to treat IBD and IBD‐associated anxiety and depression by modulating the microbiota‐gut‐brain axis. SP@Rh‐gel improves the solubility, release characteristics and intestinal retention capacity of the drug, leading to a significant improvement in the oral therapeutic efficacy. Oral administration of SP@Rh‐gel can reduce intestinal inflammation and rebalance the disrupted intestinal microbial community. Furthermore, SP@Rh‐gel maintains intestinal barrier integrity and reduces the release of pro‐inflammatory factors and their entry into the hippocampus through the blood‐brain barrier, thereby inhibiting neuroinflammation and maintaining neuroplasticity. SP@Rh‐gel significantly alleviates the colitis symptoms, as well as anxiety‐ and depression‐like behaviors, in a chronic colitis mouse model. This study demonstrates the significant involvement of the microbiota‐gut‐brain axis in the development of IBD with psychiatric disorders and proposes a safe, simple, and highly efficient therapeutic approach for managing IBD and comorbid psychiatric disorders.
Mechanical Stimulation of Anti‐Inflammatory and Antioxidant Hydrogels for Rapid Re‐Epithelialization
Authors: Yang Wei , Zhong Wenwen , Yan Shengtao , Wang Shuting , Xuan Chengkai , Zheng Ke , Qiu Jianguang , Shi Xuetao 
Published: January 2024

AbstractThe epithelium, an essential barrier to protect organisms against infection, exists in many organs. However, rapid re‐epithelialization to restore tissue integrity and function in an adverse environment is challenging. In this work, a long‐term anti‐inflammatory and antioxidant hydrogel with mechanical stimulation for rapid re‐epithelialization, mainly composed of the small molecule thioctic acid, biocompatible glycine, and γ‐Fe2O3 nanoparticles is reported. Glycine‐modified supramolecular thioctic acid is stable and possesses outstanding mechanical properties. The incorporating γ‐Fe2O3 providing the potential contrast function for magnetic resonance imaging observation, can propel hydrogel reconfiguration to enhance the mechanical properties of the hydrogel underwater due to water‐initiated release of Fe3+. In vitro experiments show that the hydrogels effectively reduced intracellular reactive oxygen species, guided macrophages toward M2 polarization, and alleviated inflammation. The effect of rapid re‐epithelialization is ultimately demonstrated in a long urethral injury model in vivo, and the mechanical stimulation of hydrogels achieves effective functional replacement and ultimately accurate remodeling of the epithelium. Notably, the proposed strategy provides an advanced alternative treatment for patients in need of large‐area epithelial reconstruction.
Piezoionic Elastomers by Phase and Interface Engineering for High‐Performance Energy‐Harvesting Ionotronics
Authors: Zhu Weiyan , Wu Baohu , Lei Zhouyue , Wu Peiyi 
Published: January 2024

AbstractPiezoionic materials play a pivotal role in energy‐harvesting ionotronics. However, a persistent challenge lies in balancing the structural requirements for voltage generation, current conduction, and mechanical adaptability. The conventional approach of employing crystalline heterostructures for stress concentration and localized charge separation, while effective for voltage generation, often compromises the stretchability and long‐range charge transport found in homogeneous quasisolid states. Herein, phase and interface engineering strategy is introduced to address this dilemma and a piezoionic elastomer is presented that seamlessly integrates ionic liquids and ionic plastic crystals, forming a finely tuned microphase‐separated structure with an intermediate phase. This approach promotes charge separation via stress concentration among hard phases while leveraging the high ionic charge mobility in soft and intermediate phases. Impressively, the elastomer achieves an extraordinary piezoionic coefficient of about 6.0 mV kPa−1, a more than threefold improvement over current hydrogels and ionogels. The resulting power density of 1.3 µW cm−3 sets a new benchmark, exceeding that of state‐of‐the‐art piezoionic gels. Notably, this elastomer combines outstanding stretchability, remarkable toughness, and rapid self‐healing capability, underscoring its potential for real‐world applications. This work may represent a stride toward mechanically robust energy harvesting systems and provide insights into ionotronic systems for human–machine interaction.
Synthesis of 1,4‐Dihydropyridines via Addition of Furfural‐Derived Trienolates to Pyridiniums under NHC Catalysis
Authors: Xu Yuan‐Yuan , Jin Ming‐Lei , Gao Zhong‐Hua , Ye Song 
Published: January 2024

AbstractBoth furan and 1,4‐dihydropyridine (1,4‐DHP) are key structural motifs in pharmaceuticals. Herein, we report the synthesis of 4‐(furan‐2‐ylmethyl)‐1,4‐dihydropyridines from pyridiniums and furfural derivatives under NHC catalysis. This reaction involves the generation of NHC‐bounded trienolates from furfural derivatives and following addition to the C‐4 position of N‐aryl pyridinium salts. This protocol features good yields (41–99%), and high levels of regioselectivity (>20:1 for all cases).
Hydroformylation of Alkynyl Sulfides: A Stereo‐ and Regioselective Route to α‐Sulfenyl Acroleins
Authors: Wagner Patrick , Gulea Mihaela , Girard Nicolas 
Published: January 2024

AbstractThe rhodium‐catalyzed hydroformylation of alkynyl sulfides at 40 °C under 5 bars of syngas is described. The method gives access to α‐sulfenyl acroleins with α/β regioselectivities up to 89/11 and is applicable to alkyl or aryl substituted substrates. It is effective even on more complex substrates, such as cysteine and cholesterol derivatives. To demonstrate the synthetic potential of the obtained products, (Z)‐3‐cyclohexyl‐2‐methylsulfenyl acrolein was selected as an example and its sulfur atom selectively oxidized to the corresponding sulfoxide or sulfone. Acid‐promoted (Z) to (E) isomerization of the double bond occurred during oxidation. The three obtained sulfenyl‐, sulfinyl‐, and sulfonyl‐functionalized acroleins have been then used as dienophiles to access cyclohexene carbaldehydes.
Site‐Selective Pyridination of Benzylic and Allylic C−H bonds via Radical‐Radical Cross‐Coupling
Authors: Chen Jun‐Jie , Wang Zhan‐Jie , Huang Huan‐Ming 
Published: January 2024

AbstractHerein, we report a modular photocatalytic platform for the site‐selective pyridination of saturated hydrocarbon compounds employing organic photoredox catalysis to forge new carbon‐carbon bonds. The site‐selective C−H pyridination could couple benzylic/allylic C−H bonds with pyridylphosphonium salts, which installed directly and regioselectively from C−H heteroarenes through a radical‐radical cross coupling mechanism. This synthetic methodology could tolerate a variety of functional groups, complex heteroarenes, even late‐stage functionalization of pharmaceuticals selectively.
Application of Cell Membrane Vesicles in Cancer Diagnosis and Treatment
Authors: Cheng Yun , Wu Haoan , Ma Ming , Zhang Yu 
Published: January 2024

AbstractApplication of nanoparticles in cancer diagnosis and treatment has gained much attention in the past decade. Because of the advantages of cargo protection, targeting delivery, controlled release, and so on, nanoparticles are widely applied in cancer therapies. However, bare nanoparticles prove not potent enough. Obstacles of immune rejection, low targeting rate, and insufficient circulation time limit the application of bare nanoparticles against cancer. Therefore, inspired by surface modification, invention of cell membrane coating technology has solved the above problems. Nanoparticles camouflaged in cell membranes not only improve biocompatibility, but also benefit from weak immunogenicity, homotypic fusion, prolonged circulation time, and other specialized properties bestowed by source cells accordingly. Through combination of cell membrane vesicles and other novel techniques, innovative methods of cancer diagnosis and treatment are feasible. Here recent advances in cell membrane coating technology are discussed. Apart from introducing methodology of cell membrane vesicle fabrication and characterization, examples of cell membrane vesicle with diverse source cells are given to present specialized application properties. A proposition of constructing donor cell database and cell membrane vesicle bank is presented to counter the current challenges in clinical application.