bluuebunny/crossref_metadata_2025_split huggingface dataset:
Marker-Assisted Introgression of ‘Co-14’ Gene to Common Bean (Phaseolus vulgaries L.) against Anthracnose (Colletotrichum lindemuthianum)
Authors: Ebrahim Muhammed Sitote , Bisetegn Kassahun Bantte , RezeneTedla Yayis 
Published: December 2023

Abstract
Bean anthracnose is one of the major constraints for the production of common beans in Ethiopia. This study aims to introgress the Co-14 R-gene and creating parental bean cultivars with desirable traits as potential sources of resistance genes in breeding programs. Marker-assisted backcross breeding was used to introgress Co-14 R-gene tagged by CV542014 marker from the donor parent (KT-RWA77) to the recurrent parent (KT-IBMV4). Progenies in each generation were selected using sequence tagged site marker (CV542014). An experiment was conducted using parental lines, eight BC2F2 isolines, and two released varieties along with three anthracnose races (2047, 1716, and 2342) in the study for phenotypic evaluation of isolines against anthracnose pathogens. The experiment was conducted using a factorial completely randomized design (CRD). The collected data were analyzed using SAS 9.3 software. From genotypic selection, five BC2F2 plants were identified as introgressed lines for anthracnose R-gene from the crosses of KT-IBMV4 and KT-RWA77 with the aid of marker-assisted selection. The result indicated anthracnose R gene (Co-14) was successfully introgressed and traced with the MAS. Again, the analysis of variance (ANOVA) revealed highly significant differences (p < 0.001) among the BC2F2 lines, races, and their interaction. Among the lines, four BC2F2 lines (Plant-3, Plant-5, Plant-9, and Plant-15) showed the lowest mean severity to the three tested races compared with other lines. The BC2F2 lines specifically plant-3 and plant-15 were selected with resistance to anthracnose and Co-14 marker presence. The two BC2F2 lines namely Plant-3 and Plant-15 could be recommended as sources of resistance to anthracnose disease. However, the remaining two BC2F2 lines viz. plant-5 and Plant-9 had resistance reaction to anthracnose disease and were recommended for production after verification where anthracnose disease is widely distributed. Generally, the identified lines would be used as parental materials for the next backcrossing program.
The Use of Artificial Neural Network for Modeling Adsorption of Congo Red Onto Activated Hazelnut Shell
Authors: Mesutoğlu Özgül Çimen 
Published: December 2023

Abstract
Activated hazelnut shell (HSAC), an organic waste, was utilized for the adsorptive removal of Congo Red (CR) dye from aqueous solutions, and a modeling study was conducted using Artificial Neural Networks (ANNs). For the adsorption study, pH (3-9), initial CR concentration (5-400 mg/L), contact time (2-240 min.), and adsorbent quantity (0.5-10 g/L) parameters were investigated. Conducted in a batch system, the adsorption experiments resulted in a notable removal efficiency of 87% under optimal conditions. The kinetic data for hazelnut shell activated carbon (HSAC) removal of CR were most accurately represented by the pseudo-second-order kinetic model. Furthermore, the equilibrium data demonstrated a strong agreement with the Freundlich model. The maximum adsorption capacity of HSAC for CR was determined to be 34.8 mg/g. Considering the various experimental parameters influencing CR adsorption, an Artificial Neural Network (ANN) model was constructed. The analysis of the ANN model revealed a correlation of 98%, indicating that the output parameter could be reliably predicted. Thus, it was concluded that ANN could be employed for the removal of CR from water using HSAC.
Performance of three anion-exchange membranes in fluoride ions removal by electrodialysis
Authors: Addar Fatima Zahra , Mohamed Idrisse , Kitanou Sarra , Tahaikt Mustapha , Elmidaoui Azzedine , Taky Mohamed 
Published: December 2023

Abstract
The performance of three anion-exchange membranes (AEMs) in the fluoride ions reduction by electrodialysis (ED) is performed on real and synthetic water. The electric potential method measures the potential difference (PD) between two synthetic anion solutions separated by ACS, AFN and AXE membranes. The selectivity of these three AEMs coupled with the membrane CMX, is a cation-exchange membrane (CEM) towards different ions. The removal rate is influenced by the thickness of the polarization layer (PL) which reduces the material transfer and provides an additional barrier. The greater the thickness δ of the PL, the longer the passage time and consequently the removal rate of anions is small. Using the unstirred layer model, δ for each ion will be determined. According to the potential measurement method, none of the tested AEMs are selective to fluoride ions and the order of selectivity is as follows: AFN&gt; AXE&gt; ACS. Best membrane couple selected for fluoride ion removal is ACS/CMX and ion selectivity follows the order: Cl−&gt; NO−3&gt;F−&gt; HCO−3&gt; SO42−. For ACS membrane, both the demineralization rate (DR) and δ of fluoride ions are influenced by the initial concentration of the co-ion according to the following order: NO−3&gt; Cl−&gt; HCO−3&gt; SO2−4.
Communication Disorders Resulting from School Violence: Challenges in Education for Peace
Authors: Czarnecka Martyna , Żelazkowska Mariola , Toussaint Loren 
Published: December 2023

Agresja i przemoc w środowisku szkolnym są uznawane za jeden z najpoważniejszych problemów, z którymi musi mierzyć się szkoła. Stanowią również jeden z największych zagrożeń dla zdrowia psychicznego dzieci i młodzieży, nierzadko bywają przyczyną urazów fizycznych, a w skrajnych przypadkach mogą doprowadzić do śmierci. Przemoc generuje poważne, różnorodne problemy na wielu płaszczyznach życia człowieka. Jedne z tych utrudnień widoczne są na płaszczyźnie komunikacji. Zaburzenia komunikacji są sytuacją, w której pojawia się trudność w porozumiewaniu się z innymi. Mogą mieć formę agresji werbalnej lub wynikać z braku komunikacji, czyli przyjmowania postawy biernej (łączy się to z niewyrażaniem emocji, tłumieniem ich). Uczniowi, który ma problemy w komunikacji interpersonalnej jest trudno realizować swoje potrzeby emocjonalne, tj. potrzeba bezpieczeństwa, przynależności, szacunku, akceptacji, realistycznego stawiania granic i oczekiwań. W relacjach stosuje nieadaptacyjne strategie porozumiewania się. Celem niniejszego artykułu jest przedstawienie trudności z obszaru zaburzeń w komunikacji interpersonalnej wśród uczniów, które wynikają ze zjawiska przemocy. Autorki publikacji będą chciały również wskazać na wyzwania jakie stoją przed pedagogami w obszarze wychowania do pokoju w zakresie omawianego tematu.
The Dependence of the Child as a Value for Reflection on Peace in Light of the Concept of the Pedagogical Relationship—Inspired by the Thought of Max Van Manen and Lennart Vriens
Authors: Krupska Marta 
Published: December 2023

Problematyka podjęta w przedstawionej pracy jest ściśle związana z rozwojem idei relacji pedagogicznej, zajmującej szczególnie ważne miejsce w zainteresowaniach badawczych współczesnych przedstawicieli pedagogiki fenomenologicznej na świecie takich jak Max van Manen, Tone Saevi czy Carina Henricsson. Przywołani badacze w szczególnie istotny sposób inspirują się tradycją badawczą tzw. Szkoły w Utrechcie oraz koncepcją „phenomenology of practice”, którą rozwinął uczeń Martinusa Langevelda, Max van Manen. Łączy ich wpływ Emmanuela Levinasa, a rozwijana przez nich koncepcja relacji pedagogicznej w centrum swojej etycznej perspektywy stawiają zatem zależność i kruchość dziecka oraz odpowiedzialność dorosłego. Problematyka heteronomii w relacji pedagogicznej odsłania swoje ogromne znaczenie dla rozwijanej w perspektywie fenomenologicznej i egzystencjalnej pedagogicznej problematyki pokoju. Druga część artykułu koncentruje się na kilku inspiracjach płynących z badań Lennarta Vriensa, który prowadził badania nad żywym doświadczeniem dziecka w odniesieniu do wychowania dla pokoju
Wyniki przeprowadzonej analizy wyraźnie wskazują na ogromną potrzebę podejmowania dalszej refleksji nad tym czym dla dziecka jest doświadczenie pokoju i jakiej wiedzy etyczno - pedagogicznej naprawdę potrzebujemy, by budować pokój. Każdy z nas indywidualnie jako osoba - i jako wspólnota.
Effect of Academic-related and Teaching and Learning-Related Stressors on
Eating Habits among Medical Students: A Cross-sectional Study
Authors: Khanum Kinzaa Batool , Singh Purnima , Nishat Mahveen , Rabia Bibi , Sreejith Anusha 
Published: December 2023

Introduction::
Stress occurs when people are faced with challenges and feel overwhelmed. Too much stress can cause negative effects on the body. Medical
students especially feel a lot of stress due to their curriculum, which affects their eating habits and, in turn, their academic performance.

Objective::
This study aimed to assess the effects of academic-related and teaching and learning-related stressors on the pattern of eating habits.

Material and Methodology::
A cross-sectional study was carried out among students of private medical universities in UAE. MBBS and BDS students of and above the age of
eighteen were included. A standardized questionnaire (Medical Student Stressor Questionnaire) was used to collect data. SPSS version 28 was used
to analyze the data.

Results::
We identified two main types of stressors: Academic Related Stressors (ARS) and Teaching and Learning Related Stressors (TLRS), resulting in
high levels of stress causing them to eat more than usual or less than usual. Most students (82.6%) who ate less or much less than usual had
experienced high or severe stress due to academic-related stressors of ‘strenuous task’ (P=0.007). Moreover, 81.5% of students who ate more than
usual had experienced high or severe stress when they were nervous and stressed (P=0.004). When feeling “difficulties pile up” and during times
when students “lacked confidence” due to teaching-related stressors, 71.7% and 66.3% of the participants experienced mild/moderate stress,
respectively and ate less or much less than usual (P<0.05).

Conclusion::
We were able to determine the effect of academic-related stressors (ARS) and teaching and learning-related stressors (TLRS) on eating habits. This
has led us to discover the importance of well-developed and improved intervention programs by universities to reduce stress and promote healthy
eating habits among medical students.
The use of SP/Neurokinin-1 as a Therapeutic Target in Colon and Rectal Cancer
Authors: Martín-García Desirée , Téllez Teresa , Redondo Maximino , García-Aranda Marilina 
Published: December 2023

:
Different studies have highlighted the role of Substance P / Neurokinin 1 Receptor
(SP/NK-1R) axis in multiple hallmarks of cancer including cell transformation,
proliferation, and migration as well as angiogenesis and metastasis of a wide range of
solid tumors including colorectal cancer. Until now, the selective high-affinity antagonist
of human SP/NK1-R aprepitant (Emend) has been authorized by the Food and Drug
Administration as a low dosage medication to manage and treat chemotherapy-induced
nausea. However, increasing evidence in recent years support the potential utility of
high doses of aprepitant as an antitumor agent and thus, opening the possibility to the
pharmacological repositioning of SP/NK1-R antagonists as an adjuvant therapy to conventional
cancer treatments. In this review, we summarize current knowledge on the
molecular basis of colorectal cancer as well as the pathophysiological importance of
SP/NK1-R and the potential utility of SP/NK-1R axis as a therapeutic target in this malignancy.
Neurosteroids and their Therapeutic Potential: Remembering the
Contribution of Dr. Sabina Luchetti, Netherlands Institute for
Neuroscience, Amsterdam, Netherlands
Authors: di Michele Flavia 
Published: December 2023

Abstract:
This article traces the career of Dr. Sabina Luchetti (1969–2021), a noted physician
(medical doctor, specialized in Neurology at Tor Vergata University of Rome, Italy), a dedicated
neuroscientist (Ph.D. in Neuroscience at Tor Vergata University and IRCCS Santa Lucia of
Rome), and a member of a renowned Netherlands group (senior researcher at Professor Swaab
Laboratory of the Netherlands Institute for Neuroscience, Amsterdam, Netherlands), working in
the field of brain function and diseases. She is particularly involved in the study of natural compounds,
such as neurosteroids and their biosynthetic pathways in neurodegenerative and neuroinflammation-
related disorders, working on post-mortem human brains.

:
This editorial outlines Dr. Luchetti's wide range of interests, discloses her superior fund of knowledge,
and recollects her humanitarian spirit, all of which contribute to creating a great sense of belonging
to any group of researchers whom she worked with. The impact of Dr. Luchetti's work
will continue to be felt for many years.

:
From the bench to the bedside, her work has indirectly contributed to shedding light on the neurosteroids’
potential therapeutic effects, considering that neurosteroids and their analogues (some of
which are over-the-counter) are now used to treat depression, epilepsy, and substance abuse disorders.
Moreover, the potential therapeutic effects of allopregnanolone with respect to its capability
to promote neuroregeneration and neuroprotection are a promising basis for future treatment of
neurodegenerative diseases.
Understanding the Therapeutic Approaches for Neuroprotection
Authors: Payal Nazrana , Sharma Lalit , Sharma Aditi , Hobanii Yahya Hosan , Ahmed Hakami Mashael , Ali Nemat , Rashid Summya , Sachdeva Monika , Gulati Monica , Yadav Shivam , Chigurupati Sridevi , Singh Abhiav , Khan Haroon , Behl Tapan 
Published: December 2023

Abstract:
The term “neurodegenerative disorders” refers to a group of illnesses in which deterioration of
nerve structure and function is a prominent feature. Cognitive capacities such as memory and decision-making
deteriorate as a result of neuronal damage. The primary difficulty that remains is safeguarding neurons since
they do not proliferate or regenerate spontaneously and are therefore not substituted by the body after they
have been damaged. Millions of individuals throughout the world suffer from neurodegenerative diseases.
Various pathways lead to neurodegeneration, including endoplasmic reticulum stress, calcium ion overload,
mitochondrial dysfunction, reactive oxygen species generation, and apoptosis. Although different treatments
and therapies are available for neuroprotection after a brain injury or damage, the obstacles are inextricably
connected. Several studies have revealed the pathogenic effects of hypothermia, different breathed gases, stem
cell treatments, mitochondrial transplantation, multi-pharmacological therapy, and other therapies that have improved
neurological recovery and survival outcomes after brain damage. The present review highlights the use
of therapeutic approaches that can be targeted to develop and understand significant therapies for treating neurodegenerative
diseases.
Exploring the Action Mechanism and Validation of the Key Pathways of
Dendrobium officinale Throat-clearing Formula for the Treatment of
Chronic Pharyngitis Based on Network Pharmacology
Authors: Fang Xi , Jiang Xiao-Feng , Zhang Yi-Piao , Zhou Cheng-Liang , Dong Ying-Jie , Bo-Li  , Lv Gui-Yuan , Chen Su-Hong 
Published: December 2023

Aim:
This study investigated the molecular action mechanism of a compound herb,
also known as the Dendrobium officinale throat-clearing formula (QYF), by using network
pharmacology and animal experimental validation methods to treat chronic pharyngitis (CP).

Methods:
The active ingredients and disease targets of QYF were determined by searching the
Batman-TCM and GeneCards databases. Subsequently, the drug-active ingredient-target and
protein-protein interaction networks were constructed, and the core targets were obtained
through network topology. The Metascape database was screened, and the core targets were enriched
with Gene Ontology and the Kyoto Encyclopedia of Genes and Genomes.

Results:
In total, 1403 and 241 potential targets for drugs and diseases, respectively, and 81 intersecting
targets were yielded. The core targets included TNF, IL-6, and IL-1β, and the core
pathways included PI3K-Akt. The QYF treatment group exhibited effectively improved general
signs, enhanced anti-inflammatory ability in vitro, reduced serum and tissue expressions of TNF-
α, IL-6, and IL-1β inflammatory factors, and decreased blood LPS levels and Myd88, TLR4,
PI3K, Akt, and NF-κB p65 protein expression in the tissues.

Conclusion:
QYF could inhibit LPS production, which regulated the expression of the
TLR4/PI3K/Akt/NF-κB signaling pathway to suppress the expression of the related inflammatory
factors (i.e., TNF-α, IL-6, and IL-1β), thereby alleviating the CP process.
Mitochondrial Dysfunction and Imeglimin: A New Ray of Hope for the
Treatment of Type-2 Diabetes Mellitus
Authors: Swain Jayshree , Jadhao Pooja , Sravya S. L. , Teli Brij , Lavanya Kasukurti , Singh Jaspreet , Sahoo Abhay , Das Srijit 
Published: December 2023

Abstract:
Diabetes is a rapidly growing health challenge and epidemic in many developing countries,
including India. India, being the diabetes capital of the world, has the dubious dual distinction
of being the leading nations for both undernutrition and overnutrition. Diabetes prevalence has increased
in both rural and urban areas, affected the younger population and increased the risk of
complications and economic burden. These alarming statistics ring an alarm bell to achieve glycemic
targets in the affected population in order to decrease diabetes-related morbidity and mortality.
In the recent years, diabetes pathophysiology has been extended from an ominous triad through octet
and dirty dozen etc. There is a new scope to target multiple pathways at the molecular level to
achieve a better glycemic target and further prevent micro- and macrovascular complications. Mitochondrial
dysfunction has a pivotal role in both β-cell failure and insulin resistance. Hence, targeting
this molecular pathway may help with both insulin secretion and peripheral tissue sensitization to
insulin. Imeglimin is the latest addition to our anti-diabetic armamentarium. As imeglimin targets,
this root cause of defective energy metabolism and insulin resistance makes it a new add-on therapy
in different diabetic regimes to achieve the proper glycemic targets. Its good tolerability and efficacy
profiles in recent studies shows a new ray of hope in the journey to curtail diabetes-related morbidity.
HMGB1/RAGE Signaling Regulates Th17/IL-17 and Its Role in Bronchial Epithelial-Mesenchymal Transformation
Authors: Sun Jingyi , Jiang Yan , Li Linqiao , Li Rou , Ling Feixiang , Du Xiaojing , Han Qian , Chu Shuyuan , Liang Yaxi , Mai Lin , Ma Libing 
Published: December 2023

Background:
Airway remodeling is one of the reasons for severe steroidresistant
asthma related to HMGB1/RAGE signaling or Th17 immunity

Objective:
Our study aims to investigate the relationship between the HMGB1/RAGE
signaling and the Th17/IL-17 signaling in epithelial-mesenchymal transformation (EMT)
of airway remodeling.

Methods:
CD4+ T lymphocytes were collected from C57 mice. CD4+ T cell and Th17
cell ratio was analyzed by flow cytometry. IL-17 level was detected by ELISA. The Ecadherin
and α-SMA were analyzed by RT-qPCR and immunohistochemistry. The Ecadherin,
α-SMA, and p-Smad3 expression were analyzed by western blot.

Results:
The HMGB1/RAGE signaling promoted the differentiation and maturation of
Th17 cells in a dose-dependent manner in vitro. The HMGB1/RAGE signaling also
promoted the occurrence of bronchial EMT. The EMT of bronchial epithelial cells was
promoted by Th17/IL-17 and the HMGB1 treatment in a synergic manner. Silencing of
RAGE reduced the signaling transduction of HMGB1 and progression of bronchial
EMT.

Conclusion:
HMGB1/RAGE signaling synergistically enhanced TGF-β1-induced
bronchial EMT by promoting the differentiation of Th17 cells and the secretion of IL-17.
The Safety and Efficacy of Leo Stents with Coiling or Alone for Anterior Cerebral Artery Aneurysms
Authors: Duan Yu , Shen Jun , Qin Xuanfeng , Xu Binbin , Mao Renling , Li Jian , An Qinzhu , Liao Yujun , Zhang Fayong , Chen Gong 
Published: December 2023

Introduction:
Treatment of anterior cerebral artery (ACA) aneurysms is still not well
established. The Leo stent with blood flow direction is a retrievable stent for intracranial aneurysms,
whereas it needs to be studied clearly in patients with ACA aneurysms.

Methods:
Consecutive patients with ACA aneurysms were retrospectively enrolled in three neurosurgical
centers between January 2016 and October 2021. The data on demographics, aneurysm
characteristics, symptom resolution, and postoperative course were collected and analyzed.
The aneurysm occlusion status was appraised by Raymond-Ray Occlusion Class (RROC).

Results:
A total of 57 patients with ACA aneurysms were included in our study. Immediate postprocedural
angiograms showed that 20 aneurysms (35.1%) were in complete occlusion (RROC 1),
26 aneurysms (45.6%) were in near-complete occlusion (RROC 2), 11 aneurysms (19.3%) were in
incomplete occlusion (RROC 3). The angiographic follow-up found that the rate of complete occlusion
increased to 57.9%, and near-completion and incomplete occlusion dropped to 29.8% and
12.3%, respectively. The angiographic result of the last follow-up improved significantly (Z=-
2.805, P=0.005). Univariate analysis indicated that distal location of aneurysms (Z=4.538,
P=0.033) and ruptured aneurysms (χ2=.6120, P=0.032) were potential risk factors for intra-parent
artery narrowing. Furthermore, multivariate logistic regression analysis found that A3 aneurysms
(95% CI 1.427~32.744, P=0.016) are the key risk factor for intra-parent artery narrowing.

Conclusions:
The Leo stent is safe and effective for aneurysms located in ACA circulations. The
overall occlusion degree improved during follow-up. A distal, small artery was the risk factor for
intra-parent artery narrowing.
New Neuroimaging Findings in Patients with Molybdenum Cofactor Deficiency
Type A: A Case Report and Literature Review
Authors: Liu Hui , Yu Xiaohe , He Singting , Li Shuquan 
Published: December 2023

Introduction::
Molybdenum cofactor deficiency (MoCD-A) is an extremely rare autosomal recessive disease that presents with intractable seizures. The diagnosis
poses challenges due to the limited number of cases reported worldwide. Magnetic resonance imaging (MRI) is a useful diagnostic tool that can
detect brain injury associated with the disorder. The prognosis of MoCD-A is poor partly because most cases are initially misdiagnosed as HIE
(hypoxic ischemic encephalopathy), emphasizing the need for an early and accurate diagnosis to improve quality of life and provide adequate
genetic counseling to avoid new cases in the future.

Case Report::
This report presents a case of molybdenum cofactor deficiency type A (MoCD-A) caused by MOCS1 gene mutations. A male newborn was
admitted on the 10th day of birth due to uncontrolled seizures and feeding difficulties. Brain MRI showed severe cerebral damage with multiple
foci that did not enhance upon contrast administration. The diagnosis was confirmed by genetic analysis and the patient received rehabilitation. His
parents also received genetic counseling. To the best of our knowledge, this is the first reported MoCD-A case that had enhanced MR imaging with
Gd-DTPA (0.1 mmol/kg). In addition, we reviewed the clinical and neuroimaging features of 25 newborns diagnosed with MoCD-A, as
documented in the existing literature.

Conclusion::
MRI is crucial in the diagnosis of MoCD-A. A correct diagnosis can provide the family with timely genetic counseling to prevent future cases.