bluuebunny/crossref_metadata_2025_split huggingface dataset:
Quality of Life in Women With Breast Cancer During the First Year After Random Assignment to Adjuvant Treatment With Marrow-Supported High-Dose Chemotherapy With Cyclophosphamide, Thiotepa, and Carboplatin or Tailored Therapy With Fluorouracil, Epirubicin, and Cyclophosphamide: Scandinavian Breast Group Study 9401
Authors: Brandberg Yvonne , Michelson Helena , Nilsson Bo , Bolund Christina , Erikstein Bjørn , Hietanen Päivi , Kaasa Stein , Nilsson Jonas , Wiklund Tom , Wilking Nils , Bergh Jonas 
Published: September 2003

Purpose: To compare, in high-risk breast cancer patients, the effects on health-related quality of life (HRQoL) of two adjuvant treatments. Treatments were compared at eight points during the first year after random assignment to treatment with tailored fluorouracil, epirubicin, and cyclophosphamide (FEC) therapy for nine courses versus induction FEC therapy for three courses followed by high-dose chemotherapy with cyclophosphamide, thiotepa, and carboplatin (CTCb) supported by peripheral-blood stem cells. Patients and Methods: From March 1994 to March 1998, 525 breast cancer patients (estimated relapse risk > 70% within 5 years with standard therapy) were included in the Scandinavian Breast Group 9401 study. HRQoL evaluation, using the European Organization for Research and Treatment of Cancer Quality of Life Questionnaire (EORTC QLQ)-C30 and EORTC Breast Cancer Module–23, included 408 of 446 eligible patients in Finland, Norway, and Sweden. Results: Eighty-four percent to 95% of the patients completed questionnaires at eight points of assessment. Nostatistically significant overall differences were found between the tailored FEC group and the CTCb group for any of the HRQoL variables. Statistically significant differences over time were found for all HRQoL variables. HRQoL in the CTCb group demonstrated a steeper decrease, but a faster recovery than in the tailored FEC group. Emotional functioning improved with increased time from randomization. Higher levels of problems in body image and arm symptoms were reported in the tailored FEC group compared with the CTCb group. Sexual functioning and satisfaction were impaired during the study period. Conclusion: Both treatments had a negative influence on HRQoL during the treatment period. Despite the aggressive therapies, the patient’s HRQoL returned to levels found at inclusion on most variables.
Effect of Arsenic Trioxide on QT Interval in Patients With Advanced Malignancies
Authors: Barbey Jean T. , Pezzullo John C. , Soignet Steven L. 
Published: September 2003

Purpose: Arsenic trioxide is an effective treatment for patients with acute promyelocytic leukemia (APL) who have relapsed from or are refractory to all-trans-retinoic acid and anthracycline chemotherapy. Since arsenic can prolong the QT interval and lead to torsade de pointes, a life-threatening ventricular arrhythmia, this retrospective analysis was conducted to determine the degree of QT prolongation in patients treated with arsenic trioxide. Patients and Methods: Clinical data and serial ECGs from 99 patients with advanced malignancies who received 170 courses of arsenic trioxide in either a phase I or phase II investigational study were reviewed. Results: Prolonged QT intervals developed in 38 patients (26 patients had intervals ≥ 500 milliseconds). Compared with baseline, the heart rate—corrected (QTc) interval was prolonged by 30 to 60 milliseconds in 36.6% of treatment courses, and by more than 60 milliseconds in 35.4% of patients. The degree of prolongation was higher in men than in women during the first course of therapy, and in patients with hypokalemia. In patients receiving multiple courses, QTc intervals returned to pretreatment levels before the second course, signifying that arsenic trioxide does not permanently prolong the QTc interval. One hypokalemic, arsenic trioxide–treated patient with relapsed APL developed asymptomatic torsade de pointes, which resolved spontaneously and did not recur after electrolyte replacement. There were no sudden or arrhythmia-related deaths. Conclusion: This analysis shows that arsenic trioxide can prolong the QTc interval. However, with appropriate ECG monitoring and management of electrolytes and concomitant medications, arsenic trioxide can be safely administered in patients with relapsed APL.
Inherited and Acquired Risk Factors for Venous Thromboembolic Disease Among Women Taking Tamoxifen to Prevent Breast Cancer
Authors: Duggan Catherine , Marriott Kevin , Edwards Rob , Cuzick Jack 
Published: September 2003

Purpose: Venous thromboembolism (VTE) is of particular concern in women receiving tamoxifen in a chemopreventive setting. We investigate the association between acquired and inherited risk factors for VTE in the International Breast Cancer Intervention Study (IBIS-I) trial of tamoxifen prophylaxis for women at increased risk of breast cancer. Methods: We used a nested case-control study design to investigate the role of tamoxifen and acquired risk factors in the risk of developing a VTE. Results: Tamoxifen was associated with a significantly increased risk of developing a major VTE (odds ratio [OR], 2.1; 95% CI, 1.1 to 4.1). Women who had surgery, immobilization, or fracture in the previous month had a greatly increased risk of developing a major VTE (OR, 4.7; 95% CI, 2.2 to 10.1). Prothrombin and factor V Leiden mutations were found exclusively among control women: factor V Leiden in eight of 159 control women (5.0%) and the prothrombin mutation in three control women (1.9%). Thirty-five women with a VTE and a blood sample were negative for these mutations. The upper one-sided 97.5% CI for the OR of having either mutation was 1.87. Being overweight, smoking, or taking hormone replacement therapy was not associated with VTE in this study, but the CIs were wide. Conclusion: Tamoxifen and prior surgery, fracture, or immobilization were associated with a significantly increased risk of developing a VTE. Factor V Leiden and prothrombin mutations were not associated with thrombosis in this population.
Childhood T-Cell Acute Lymphoblastic Leukemia: The Dana-Farber Cancer Institute Acute Lymphoblastic Leukemia Consortium Experience
Authors: Goldberg John M. , Silverman Lewis B. , Levy Donna E. , Dalton Virginia Kimball , Gelber Richard D. , Lehmann Leslie , Cohen Harvey J. , Sallan Stephen E. , Asselin Barbara L. 
Published: September 2003

Purpose: T-cell acute lymphoblastic leukemia (T-ALL) accounts for 10% to 15% of newly diagnosed cases of childhood acute lymphoblastic leukemia (ALL). Historically, T-ALL patients have had a worse prognosis than other ALL patients. Patients and Methods: We reviewed the outcomes of 125 patients with T-ALL treated on Dana-Farber Cancer Institute (DFCI) ALL Consortium trials between 1981 and 1995. Therapy included four- or five-agent remission induction; consolidation therapy with doxorubicin, vincristine, corticosteroid, mercaptopurine, and weekly high-dose asparaginase; and cranial radiation. T-ALL patients were treated the same as high-risk B-progenitor ALL patients. Fifteen patients with T-cell lymphoblastic lymphoma were also treated with the same high-risk regimen between 1981 and 2000. Results: The 5-year event-free survival (EFS) rate for T-ALL patients was 75% ± 4%. Fourteen of 15 patients with T-cell lymphoblastic lymphoma were long-term survivors. There was no significant difference in EFS comparing patients with T-ALL and B-progenitor ALL (P = .56), although T-ALL patients had significantly higher rates of induction failure (P < .0001), and central nervous system (CNS) relapse (P = .02). The median time to relapse in T-ALL patients was 1.2 years versus 2.5 years in B-progenitor ALL patients (P = .001). There were no pretreatment characteristics associated with worse prognosis in patients with T-ALL. Conclusion: T-ALL patients fared as well as B-progenitor patients on DFCI ALL Consortium protocols. Patients with T-ALL remain at increased risk for induction failure, early relapse, and isolated CNS relapse. Future studies should focus on the identification of and treatment for T-ALL patients at high risk for treatment failure.
The Impact of a Physician Awareness Group and the First Year of Training on Hematology-Oncology Fellows
Authors: Sekeres Mikkael A. , Chernoff Miriam , Lynch Thomas J. , Kasendorf Eydie I. , Lasser Daniel H. , Greenberg Donna B. 
Published: September 2003

Purpose: To assess the impact of a Balint-like physician awareness group on hematology-oncology fellows’ attitudes and measure changes in attitudes during the first fellowship year. Patients and Methods: We used a modified crossover design in which one half of a fellowship class at a time was exposed to the group intervention over a 2-year period (2000 to 2002). Two 14-fellow classes were followed for 1 year each and were given three “attitudes” questionnaires, at the beginning, middle, and end of the academic year. Results: Forty Balint group sessions were held during the 2-year study period; 82 questionnaires of the 84 administered (98%) were recovered. Instrument content and criterion validity were demonstrated, as was topic domain reliability. Overall, mean attitude scores increased following the group intervention, from 3.6 (95% CI, 3.5 to 3.7) to 3.7 (95% CI, 3.6 to 3.8; P = .09). Within domains, scores increased in a “fellow’s views of him/herself as a physician,” from 3.8 (95% CI, 3.6 to 3.9) to 4.1 (95% CI, 3.9 to 4.2; P = .008) and “comfort dealing with emotional patient/clinical situations,” from 3.5 (95% CI, 3.3 to 3.7) to 3.7 (95% CI, 3.6 to 3.9; P = .11). Changes in responses to individual questions included: an increase in fellows’ comfort with the technical aspects of being an oncologist (P < .03); an increase in fellows’ comfort with discussing the stress of home at work (P < .023); and an increase among fellows in feeling pressed for time to discuss psychosocial issues with patients (P = .035). Conclusion: A physician awareness group was feasible and enhanced fellows’ development as physicians. Further research is needed to determine how to incorporate such groups into oncology fellowships.
Expression of CEACAM6 in Resectable Colorectal Cancer: A Factor of Independent Prognostic Significance
Authors: Jantscheff Peter , Terracciano Luigi , Lowy Adam , Glatz-Krieger Katharina , Grunert Fritz , Micheel Burkhard , Brümmer Jens , Laffer Urs , Metzger Urs , Herrmann Richard , Rochlitz Christoph 
Published: September 2003

Purpose: CEACAM6, CEACAM1, and human carcinoembryonic antigen (CEA) are coexpressed in normal colorectal epithelia, but show deregulated expression in colorectal cancers (CRC). Upregulation of CEACAM6 expression in hyperplastic polyps and early adenomas represents one of the earliest observable molecular events leading to colorectal tumors. The aim of our study was to evaluate the prognostic relevance of CEACAM6, CEACAM1, and CEA tissue expression in patients with CRC. Patients and Methods: Immunohistochemical analysis was carried out on tissue microarrays from 243 paraffin-embedded biopsies from a randomized controlled clinical trial (Swiss Group for Clinical Cancer Research [SAKK] 40/81) of adjuvant fluorouracil-based chemotherapy with CEACAM-specific monoclonal antibodies. The median follow-up was 8 years. Overall survival (OS) and disease-free survival (DFS) were calculated using Kaplan-Meier estimates and hazard ratios (HRs) estimated using Cox proportional hazards models. Results: Tissue expression of CEACAM6, CEACAM1, and CEA was enhanced in 55%, 58%, and 94% of patients, respectively. Multivariate Cox analysis including sex, age, tumor site, stage, differentiation grade, treatment, and nodal status as covariates showed that CEACAM6 overexpression independently predicted poor OS (HR, 1.86; P = .0100) and DFS (HR, 2.00; P = .0028), whereas CEACAM1 or CEA were not significantly related to these outcomes. The data did not provide evidence for or against the hypothesis that the CEACAM6 effect on survival differs according to treatment. Conclusion: Expression of the cell adhesion molecule CEACAM6 in CRC is an independent prognostic factor allowing subdivision of patients into low- and high-risk groups. Whether CEACAM6 or CEA and CEACAM1 might be useful as predictive markers of chemotherapy benefit remains unclear.
Model Study for Preparation of Asymmetric N,N′-Disubstituted Piperazine Library: Efficient Synthesis of Aryl Piperazine and Benzyl Piperazine Derivatives on the Solid Support
Authors: Yamamoto Yasuo , Ajito Keiichi , Ohtsuka Yasuo 
Published: September 2003

Abstract
Several classes of asymmetrical N,N′-disubstituted aryl piperazine and benzyl piperazine derivatives were successfully synthesized by the solid phase method from the same intermediate.
Synthesis of Copolymers Containing C60, Cyclododecyl, and Sulfonate Groups: Photophysical Behavior of C60 in Highly Constrained Microenvironments
Authors: Higashida Suguru , Nishiyama Katsura , Yusa Shin-ichi , Morishima Yotaro , Janot Jean-Marc , Seta Patrick , Imahori Hiroshi , Kaneda Takahiro , Sakata Yoshiteru 
Published: September 2003

Abstract
C60 was covalently incorporated into hydrophobic cluster of amphiphilic polysulfonates. In this cluster C60 chromophores showed extremely blue-shifted fluorescence and no thermally activated delayed fluorescence.
Polymerization of 6-Amino-6-deoxy-D-glucose Involving Amadori Rearrangement: A New Method for Synthesis of Aminopolysaccharide
Authors: Kadokawa Jun-ichi , Hino Daisuke , Karasu Masa , Tagaya Hideyuki , Chiba Koji 
Published: September 2003

Abstract
This paper describes synthesis of a new aminopolysaccharide by thermal polymerization of 6-amino-6-deoxy-D-glucose in the presence of acetic acid. The polymerization proceeded via Amadori rearrangement to give the aminopolysaccharide having aminoketose structure in the main chain. The molecular weight was determined by GPC analysis after acetylation of the product polysaccharide.
Crystallization of (Pro-Hyp-Gly)10 and Its Triple-Helical Structure Deduced from Cylindrical Patterson Map
Authors: Okuyama Kenji , Nagarajan Venugopalan , Kamitori Shigehiro , Noguchi Keiichi 
Published: September 2003

Abstract
Two morphologically different crystals of a collagen model peptide(Pro-Hyp-Gly)10 were obtained using PEG 200 as the precipitating agent. Both the crystals belonged to a monoclinic system with the space group P21 and diffracted to a resolution of 1.8 Å. Although the crystal data were quite different from those of homologous model peptide, (Pro-Pro-Gly)10, the cylindrical Patterson map showed that the main chain conformation of this compound is exactly the same as that of (Pro-Pro-Gly)10. This result supports the Okuyama model for collagen structure.
Photocatalytic Activity of RuS2/SiO2 for Water Decomposition
Authors: Hara Kohjiro , Sayama Kazuhiro , Arakawa Hironori 
Published: September 2003

Abstract
Hydrogen and oxygen were produced, respectively, from water in the presence of sacrificial reagents by photocatalytic reaction using RuS2 powder catalyst under UV light irradiation for the first time. Photocatalytic activity of RuS2 significantly improved by support on SiO2.
A Superoxodicopper(II) Complex Oxidatively Generated by a Reaction of Di-μ-hydroxodicopper(II) Complex with Hydrogen Peroxide
Authors: Kodera Masahito , Tachi Yoshimitsu , Hirota Shun , Katayama Kou , Shimakoshi Hisashi , Kano Koji , Fujisawa Kiyoshi , Moro-oka Yoshihiko , Naruta Yoshinori , Kitagawa Teizo 
Published: September 2003

Abstract
Di-μ-hydroxodicopper(II) complex with a hexapyridine dinucleating ligand, [Cu2(OH)2(hexpy)](CF3SO3)2 (hexpy=1,2-bis[2-(bis(2-pyridyl)methyl)-6-pyridyl]ethane), reacts with H2O2 in MeCN/CH2Cl2 to give a superoxodicopper(II) complex.
Electrochemical Reduction of NO on ZnO and In2O3 Semiconductor Electrodes in Aqueous K2SO4 Solutions
Authors: Kudo Akihiko , Watanabe Karoi , Minakata Yuji , Mine Akiyo 
Published: September 2003

Abstract
NO was efficiently reduced on ZnO and In2O3 of n-type semiconductor electrodes in aqueous solutions. Harmless N2 was obtained as a main reduction product. Current-potential curves on the ZnO and In2O3 electrodes under NO were quite similar to those under N2O. It is proposed that the NO reduction on the ZnO and In2O3 electrodes proceeds via the redox mechanism in which oxygen vacancies formed by the electrochemical reduction on the electrode surface play an important role.
Preparation of m-Acylaniline Derivatives by the Reaction of Tricarbonyl(cyclohexadienone O-benzyloxime)iron Complex and Higher Order Cuprates
Authors: Ban Soo Ho , Hayashi Yujiro , Narasaka Koichi 
Published: September 2003

Abstract
Reaction of tricarbonyl[(2,3,4,5-η)-2,4-cyclohexadien-1-one O-benzyloxime]iron and organocuprates, followed by the treatment with acetic anhydride and carbon monoxide, affords [(1,2,3,4-η)-1-(N-acetoxy-N-benzyloxyamino)-5-endo-acyl-1,3-cyclohexadiene]tricarbonylirons, which are converted to m-acylaniline derivatives by treating with potassium carbonate.
Regioselective Acylation of (5-Alkylidene-1,3-cyclohexadiene)tricarbonyliron Complexes by the Reaction with Organometallic Reagents
Authors: Iwakoshi Mitsuhiko , Ban Soo Ho , Hayashi Yujiro , Narasaka Koichi 
Published: September 2003

Abstract
Reaction of [(1,2,3,4-η)-5-alkylidene-1,3-cyclohexadiene]tricarbonylirons and organometallic reagents generates acyl[(1,2,3,4,5-η)-1-alkylcyclohexadienyl]dicarbonylirons. The acyl group in these complexes migrates to the cyclohexadienyl moiety under carbon monoxide atmosphere, providing [(1,2,3,4-η)-6-acyl-2-alkyl-1,3-cyclohexadiene]tricarbonylirons, which are further transformed to m-alkylphenyl ketones by the oxidation with trimethylamine N-oxide.
Asymmetric Direct α,β-Functionalization of Allenes via Asymmetric Carbopalladation
Authors: Hiroi Kunio , Kato Fumiko , Yamagata Akiko 
Published: September 2003

Abstract
Asymmetric direct α,β-functionalization of allenes with chiral phosphine ligands was successfully achieved with extremely high enantioselectivity via asymmetric carbopalladation to the racemic allenes. The same palladium-catalyzed alkylation of a chiral allene was executed with complete enantiospecificity. The stereochemistry of this reaction was determined and the mechanism of this asymmetric induction is proposed.
Selective Bindings of a Lectin for Phase-separated Glycolipid Monolayers
Authors: Hashizume Mineo , Sato Toshinori , Okahata Yoshio 
Published: September 2003

Abstract
Phase separation was observed by measuring surface pressure (π)-area (A) isotherms of the mixed monolayer of lactosylceramide (LacCer) and dioleoylphosphatidylcholine (DOPC). Bindings of Allomyrina dichotoma (allo A) lectin to LacCer in mixed monolayers were measured by means of quartz-crystal microbalance (QCM) that was attached horizontally to the monolayers. Allo A showed the high binding affinity for the LacCer phase-separated in the DOPC monolayer, but showed the low binding affinity for the LacCer homogeneously mixed with dipalmitoylphosphatidylcholine (DPPC) matrix.
Discrimination among Amino Acids Using an Amperometric Biosensor Based on Electrochemical Nonlinearity
Authors: Nakata Satoshi , Hirata Yoko , Takitani Rie , Yoshikawa Kenichi 
Published: September 2003

Abstract
We propose a novel sensing system based on the multidimensional information contained in a dynamic nonlinear response. A sinusoidal potential was applied to an amperometric L-amino acid sensor, and the resulting current of the sensor was analyzed by fast Fourier transformation (FFT). The amplitudes of the higher harmonics of the FFT characterize the nonlinear properties of the response. The amplitudes of the higher harmonics of the FFT exhibit characteristic changes which depend on the concentration and the chemical structure of amino acids at the sensor surface.
Selective Conjugate Alkylation of Alkyllithium Nucleophiles to α,β,γ,δ-Unsaturated Aldehydes with Functionalized Lewis Acid Receptors
Authors: Ooi Takashi , Kondo Yuichiro , Kon-i Kana , Maruoka Keiji 
Published: September 2003

Abstract
Selective 1,4- and 1,6-addition of alkyllithium reagents to α,β,γ,δ-unsaturated aldehydes has been successfully realized with fluorinated aluminum tris(2,6-diphenylphenoxide) (ATPH) derivatives as functionalized Lewis acid receptors.
Self-Assembly Process of Organosulfur Molecular Layers on Gold Electrode: An in situ Ellipsometric and Electrochemical Study
Authors: Eu Seunghun , Paik Woon-kie 
Published: September 2003

Abstract
Electrochemical and ellipsometric measurements were made on gold surface while alkanethiols and organic disulfides were adsorbed. Anodic oxidation was observed to occur with molecular layer formation from thiols. Disulfide molecules appeared to oxidatively adsorb after reductive dissociation.
Electron Transfer Reaction of Cytochrome c at Poly(ethylene oxide)-Thiolate-Modified Gold Electrode
Authors: Ohno Hiroyuki , Kato Ken-ichi 
Published: September 2003

Abstract
Gold electrode was modified with poly(ethylene oxide)s having thiol end (PEO-SH). The electron transfer reaction of cytochrome c was evaluated by the gold electrode modified with PEO-SH, having PEO molecular weight of 150, where the adsorption of proteins and resulting denaturation were restrained. The increase of PEO molecular weight conducted suppression of the redox responses at the modified gold electrode.
The Substituent Effect on Stereoselective Reductive Lithiation of 4,5-Disubstituted 2-Phenylthiooxolane
Authors: Amano Seiji , Fujiwara Kenshu , Murai Akio 
Published: September 2003

Abstract
In the reductive lithiation of 2-phenylthiooxolane system, the coexistence of the substituents at C2 and C3 with cis-configuration was found to increase the ratio of 2,5-trans-2-lithiooxolane at 2,5-cis derivative.
Mixed Monolayers of a Calix[4]resorcinarene with a Nematic Liquid Crystal and Their Bilayered Structuring
Authors: Matsuzawa Yoko , Seki Takahiro , Ichimura Kunihiro 
Published: September 2003

Abstract
Perpendicular orientation of nematic liquid crystalline azobenzene (C6Azo) on a water surface was demonstrated by spreading a mixture of C6Azo with O-octacarboxymethylated calix[4]resorcinarene (CRA-CM) as a host. A host-guest mixed monolayer of C6Azo with CRA-CM formed a double-layered structure by further compression.
Formation of CO(d3Δi, a′3Σ+) by Dissociative Ion-Ion Neutralization Reaction of CO2+ with C6F6− in the Helium Flowing Afterglow
Authors: Tsuji Masaharu , Oda Erika , Nakamura Masafumi , Nishimura Yukio 
Published: September 2003

Abstract
The ion-ion neutralization reaction of CO2+ with C6F6− has been spectroscopically studied in a He flowing afterglow. The CO(d3Δ1-a3Πr) transition from v′=0-3 and the CO(a′3Σ+-a3Πr) transition from v′=3-7 were observed with a CO(a′-a)/CO(d-a) ratio of 3.9. The vibrational distributions of CO(d,a′) indicated that 43 and 62 % of the total excess energies are deposited into vibrational modes of CO(d) and CO(a′), respectively.
Microscopic Solvation Effects on Si-Si Bond Cleavage Reactions of Cluster Cation Radicals of (p-Cyanophenyl)pentamethyldisilane with Hydroxylic Molecules
Authors: Tajima Yuko , Ishikawa Haruki , Shimanuki Yoichi , Miyazawa Takashi , Mikami Naohiko , Kira Mitsuo 
Published: September 2003

Abstract
Facile Si-Si bond cleavage reactions of cation radicals of jet-cooled clusters of (p-cyanophenyl)pentamethyldisilane with H2O or CH3OH were found to occur via intracluster nucleophilic attack of a solvent molecule by means of resonance-enhanced two photon ionization mass spectrometry.
Coating of POPC Giant Liposomes with Hydrophobized Polysaccharide
Authors: Ueda Takehiko , Lee Stephen J , Nakatani Yoichi , Ourisson Guy , Sunamoto Junzo 
Published: September 2003

Abstract
POPC giant liposomes were incubated with pullulan that was hydrophobized by cholesteryl groups and labelled by a fluorescent marker (FITC). Confocal laser microscopy clearly showed coating of the outer surface of the liposomes with the polymer. This is the first and direct observation of the supramolecular assembly of an artificial cell wall onto cell-sized liposomes.