bluuebunny/crossref_metadata_2025_split huggingface dataset:
भाषाशिक्षणका सामान्य र विशिष्ट पद्धतिहरू
Authors: भुसाल केशव 
Published: February 2025

भाषाशिक्षण भाषिक सीप एवम् कुशलताहरूको शिक्षण हो । भाषाशिक्षणका क्षेत्रमा विभिन्न पद्धतिहरूको प्रयोग अपरिहार्य हुन्छ । भाषाशिक्षणका सन्दर्भमा विषयगत शिक्षण पद्धतिले सिकाइ शिक्षणार्थ स्थापित सामान्य र विशिष्ट पद्धतिहरूलाई दर्साउँदछ । प्रस्तुत लेख नेपाली भाषाशिक्षणका सामान्य र विशिष्ट पद्धतिहरूको अध्ययन विश्लेषणमा आधारित रहेको छ । वस्तुतः भाषाशिक्षणको परिचय दिनु, भाषाशिक्षणका पद्धतिहरूको पहिचान गर्नु र नेपाली भाषाशिक्षणका सामान्य र विशिष्ट पद्धतिहरूको चर्चा गर्नु यस लेखका मूलभूत उद्देश्यका रूपमा रहेका छन् । प्रस्तुत लेख गुणात्मक अनुसन्धान पद्धतिमा आधारित रहेको छ । यस लेखमा पुस्तकालयीय अध्ययन पद्धतिको प्रयोग गरी आवश्यक सामग्रीहरूको अध्ययन गरिएको छ । यस क्रममा भाषाशिक्षण तथा नेपाली भाषाशिक्षणका बारेमा चर्चा गरिएका नेपाली, हिन्दी र अङ्ग्रेजी सैद्धान्तिक सामग्रीहरूलाई यस अध्ययनमा उपयोग गरिएको छ र तिनको अध्ययन–अन्वेषणबाट आवश्यक कुराहरू अध्याहार गरिएको छ । यस लेखको तयारीका क्रममा अध्ययनबाट प्राप्त कुराहरूलाई व्याख्यात्मक तथा विश्लेषणात्मक पद्धतिका माध्यमबाट प्रस्तुत गरिएको छ । यस अध्ययनबाट भाषाशिषण भाषाका चार वटा सीपहरू: सुनाइ, बोलाइ, पढाइ र लेखाइमा विद्यार्थीहरूलाई समर्थ तुल्याउन गरिने शिक्षणको रूपमा रहेको, भाषाशिक्षणका क्षेत्रमा सामान्य र विशिष्ट पद्धतिहरू प्रचलनमा रहेका, भाषाशिक्षणको प्रभावकारी व्यवहारबाट विद्यार्थीहरूमा अपेक्षित क्षमताको विकास गराउन सकिने अवस्था रहेको लगायतका निष्कर्ष निकालिएको छ । प्रस्तुत लेख भाषाशिक्षण तथा नेपाली भाषाशिक्षणका क्षेत्रमा क्रियाशील विद्वानहरू, अध्यापनरत शिक्षकहरू, अध्ययनरत विद्यार्थीहरू र सम्बद्ध सरोकारवाला सबैका लागि उपयोगी हुने अपेक्षा गरिएको छ ।
EDADISMO, UNA REALIDAD A CAMBIAR
Authors: Oriol Turró-Garriga  , Mariona Gifre-Monreal  , Glòria Pla Comas  , Pilar Monreal-Bosch  
Published: February 2025

El Edadismo, en nuestro caso, Viejismo, está relacionado con la forma que tenemos de entender la vejez y el envejecimiento, con nuestras relaciones intergeneracionales y en cómo perpetuamos estereotipos e ideas preconcebidas sobre las personas mayores, limitando, de este modo, la comprensión de la diversidad y la heterogeneidad de la vejez.
En la lucha contra el edadismo nos parece necesario educar/sensibilizar a la población general y también muy importante trabajar estos estereotipos y prejuicios con los profesionales que atienden y acompañan a las personas ya que consideramos que pueden ser, los profesionales, una palanca importante del cambio.
KUALITAS PENGARUH PEMBERIAN TEPUNG DAUN KELOR (moringa oleifera) TERHADAP ORGANOLEPTIK NUGGET DAGING AYAM LAYER AFKIR
Authors: Sari Selfa Aljulia , Komala Refika , Elisia Rini , Toni Maiyon 
Published: February 2025

AbstrakPenelitian ini bertujuan untuk mengetahui pengaruh tepung kelor (Moringa oleifera) terhadap organoleptik nugget ayam. Dalam penelitian ini menggunakan metode eksperimen dengan Rancangan Acak Lengkap (RAL) dengan menggunakan 4 perlakuan 25 ulangan yang sebagai panelis. Untuk data uji organoleptik dilanjutkan dengan menggunakan program SPSS 16 for Wndows. Analisis statistik digunakan untuk mengetahui pengaruh perlakuan adalah analisis non parametrik Kruskal-Wallis. P0 = tepung daun kelor 0 g, P1 = tepung daun kelor 7,5 g, P2 = tepung daun kelor 12,5 gram, P3 = tepung daun kelor 17,5 gram. Berdasarkan hasil penelitian dapat disimpulkan bahwa pengaruh pemberian tepung daun kelor (moringa oleifera) terhadap organoleptik nugget daging ayam layer afkir dengan perlakuan 7,5 g sampai 17,5 g berpengaruh nyata terhadap warna, tekstur, aroma dan rasa. Perlakuan terbaik dari warna P3, tekstur P1, aroma P1 dan rasa P1. Kata Kunci : daging ayam, eksperimen, tepung daun kelor, nugget, organoleptik
Komparatif Mekanisme Massawal Terhadap Profit And Loss Sharing Akuntansi Syariah di Desa Mambu Polewali Mandar
Authors: Hendra Herlinda 
Published: February 2025

Tujuan penelitian ini untuk menganalisis penerapan Massawal dan membandingkannya dengan prinsip-prinsip Profit and Loss Sharing (PLS) dalam akuntansi syariah. Penelitian ini merupakan penelitian kualitatif pendekatan religius. Metode pengumpulan data pertama adalah melalui wawancara narasumber yang berpengalaman dalam praktik Massawal. Kedua, Dokumentasi data yang dikumpulkan dianalisis untuk mengidentifikasi mekanisme pelaksanaan Massawal. Hasil penelitian menunjukkan Massawal merupakan sistem kemitraan berbasis pada kepercayaan dan nilai-nilai budaya lokal. Perjanjian awal antara pemilik dan pengelola lahan umumnya mengatur pembagian hasil tanpa adanya standar formal, pembagian keuntungan bervariasi antara 50:50 hingga 2:1, tergantung pada kesepakatan. Biaya pemeliharaan umumnya ditanggung oleh pengelola, dan kerugian yang tidak disengaja ditanggung bersama. Penelitian ini menemukan bahwa meskipun Massawal mencerminkan nilai-nilai tradisional yang kuat, terdapat perbedaan signifikan dengan sistem PLS, yang lebih terstruktur dan formal dalam dokumentasi dan regulasinya.
Servicios públicos ineficaces en Los Reyes de Salgado, Michoacán 2018-2021. Resultados de la evaluación de diseño
Authors: Torres Núñez Ma. Del Rosario , Leco Tomás Casimiro 
Published: February 2025

En esta investigación se presentan los resultados de la evaluación de diseño al programa de servicios públicos municipales de Los Reyes de Salgado, Mich., y que se emprendió por los bajos niveles en el Sistema de Evaluación del Desempeño (SED). La evaluación del programa de servicios públicos es fundamental, porque su otorgamiento incide directamente en la calidad de vida de las personas. Para realizar la evaluación se utilizaron los Términos de Referencia de CONEVAL, y de manera simultánea se evaluaron tres variables propuestas dentro de la hipótesis como posibles causantes del bajo cumplimiento en los objetivos del programa. Entre los hallazgos se encontró que la Matriz de Indicadores para Resultados no contempla las actividades ni los indicadores, se obtuvo un 1.249 de un máximo de 4.0, al tiempo que se evidenció que la participación ciudadana y la fiscalización inciden de manera favorable en el cumplimiento de objetivos del programa evaluado.
The development of a CBT-informed approach to supporting type 2 diabetes self-management
Authors: Visagie Elné , Deacon Elmari , Kok Rümando 
Published: February 2025

BackgroundThe self-management of adults with type 2 diabetes proves to be a continuous challenge. Within the South African context, socio-economic disparities, unequal access to healthcare and varying healthcare beliefs augment these challenges. CBT is a time-sensitive and structured intervention that has been effectively implemented for chronic diseases. CBT has been employed to improve psychological outcomes in adults with type 2 diabetes, but there is limited research on how this therapeutic intervention can enhance self-management outcomes of type 2 diabetes. Adaptable CBT-based interventions are needed to promote a holistic approach to type 2 diabetes self-management and empower a broader range of healthcare professionals to provide targeted interventions. Flexible interventions can promote patient engagement and be integrated into various healthcare settings where patients already access services.MethodThe study employed document analysis to develop CBT-informed guidelines. Data was analysed by means of content analysis. Two research studies formed the dataset, and categories and subcategories were identified. The categories were integrated and used to develop the CBT-informed guidelines.ResultsThese guidelines were based on core CBT components and divided into the introduction, working, and consolidation phases. The guidelines specified the roles of healthcare practitioners who would implement them and provided skills and techniques for healthcare professionals and patients within each phase.ConclusionThe CBT-based interventions aimed to provide a tool for healthcare practitioners and patients in terms of flexibility, accessibility, and personalisation.
100% oxygen mobilizes stem cells and up-regulates MIF and APRIL in humans: a new point on the hormetic dose curve
Authors: MacLaughlin Kent J. , Barton Gregory P. , MacLaughlin Julia E. , Lamers Jacob J. , Marcou Matthew D. , O’Brien Matthew J. , Braun Rudolf K. , Eldridge Marlowe W. 
Published: February 2025

IntroductionThe aim of the current study was to test normobaric 100% oxygen (NBO) (PiO2 = 713 mmHg) for stem cell mobilization and cytokine modulation. Although current oxygen therapy (PiO2 = 1,473–2,233 mmHg) is well known to mobilize stem cells and modulate cytokine, little is known about NBO and its place on the low dose stimulation phase of the hormetic dose curve of oxygen. We asked the question, will NBO mobilize stem cells and modulate cytokines. A positive outcome presents the potential to create and refine oxygen treatment protocols, expand access, and optimize patient outcomes.MethodsHealthy 30–35-year-old volunteers were exposed to 100% normobaric oxygen for 60 min, M-F, for 10 exposures over 2 weeks. Venous blood samples were collected at four time points: 1) prior to the first exposure (serving as the control for each subject), 2) immediately after the first exposure (to measure the acute effect), 3) immediately before the ninth exposure (to measure the chronic effect), and 4) three days after the final exposure (to assess durability). Blinded scientists used flow cytometry to gate and quantify the Stem Progenitor Cells (SPCs).ResultsCD45dim/CD34+/CD133+ and CD45+/CD34+/CD133+ were significantly mobilized following nine daily one-hour exposures to normobaric 100% oxygen. Conversely CD45−/CD34+/CD133+, CD45-/CD34+/CD133− and CD45−/CD34−/CD133+ phenotypes were downregulated suggesting differentiation into more mature phenotypes. The CD133+ phenotype exhibited a maturing from CD45− to CD45dim stem cells. CD45−/CD34, CD45−/CD31 and CD45−/CD105 were downregulated with no changes in related CD45dim and CD45+ phenotypes. The cytokines “macrophage migration inhibitory factor” (MIF) and “a proliferation inducing ligand” (APRIL) were significantly upregulated.ConclusionThis study demonstrates that 100% normobaric oxygen mobilizes stem cells and upregulates the expression of the inflammatory cytokines marking a new point on the low dose stimulation phase of the hormetic dose curve of oxygen.
Efficacy and safety of PCSK9 inhibitors, potent statins, and their combinations for reducing low-density lipoprotein cholesterol in hyperlipidemia patients: a systematic network meta-analysis
Authors: Jiang Yuhua , Wang Yingying , Ma Sijia , Qian Linlin , Jing Yeteng , Chen Xi , Yang Jinsheng 
Published: February 2025

BackgroundThe objective of this study is to assess the relative efficacy of proprotein convertase subtilisin/kexin type 9 (PCSK9) inhibitors, such as alirocumab, evolocumab, and inclisiran, in conjunction with potent statins like atorvastatin and rosuvastatin, in patients presenting with hyperlipidemia or heightened cardiovascular risk attributable to elevated low-density lipoprotein cholesterol (LDL-C).MethodsA systematic search was conducted across databases including PubMed, Embase, and the Cochrane Library to explore lipid-lowering therapies in hyperlipidemia from their inception to 7 November 2023. A network meta-analysis (NMA) was conducted via Stata 17 software, with two authors independently conducting the search, screening, and data abstraction.ResultsA total of 68 clinical studies involving 21,288 patients with hyperlipidemia were incorporated into the NMA. PSCK9 inhibitors and potent statins significantly reduced LDL-C levels from baseline vs. placebo regardless of background therapy. Regarding the efficacy of lipid reduction, four principal medications were evaluated: evolocumab and atorvastatin [mean standard deviation (MD) −3.41, 95% CI −4.81 to −2.00] and evolocumab with rosuvastatin (MD −3.44, 95% CI −5.10 to −1.78) vs. placebo; alirocumab combined with rosuvastatin (MD −2.91, 95% CI −3.95 to −1.88) and alirocumab with atorvastatin (MD −2.90, 95% CI −3.97 to −1.84) vs. placebo. Meanwhile, compared with placebo, evolocumab (MD −1.89, 95% CI −2.27 to −1.50), alirocumab (MD −1.83, 95% CI −2.09 to −1.57), rosuvastatin (MD −1.93, 95% CI −2.30 to −1.56), inclisiran (MD −1.68, 95% CI −2.10 to −1.27), and atorvastatin (MD −1.68, 95% CI −2.04 to −1.31) could also play a role in the treatment of LDL-C reduction. Moreover, the incidence of adverse events (AEs) was similar to that observed in the control group, which included both placebo and potent statin groups, with no significant differences identified in our study (P &gt; 0.05).ConclusionsThe combination of PCSK9 inhibitors with robust statins like rosuvastatin and atorvastatin markedly decreases LDL-C levels in patients with hyperlipidemia when compared to placebo or monotherapy. Notably, the pairing of evolocumab and atorvastatin exhibited exceptional efficacy in this investigation. In the interim, the combination of PCSK9 inhibitors and potent statins demonstrates a notable safety profile when contrasted with the control group.
The influence of maternal gestational weight gain on adverse perinatal outcomes
Authors: Yan Qingshan , Cai Wenya , Guo Yong 
Published: February 2025

ObjectiveTo analyze the impact of maternal gestational weight gain (GWG) on adverse outcomes for mothers and infants.MethodsA retrospective analysis was conducted, collecting relevant information on 9,058 singleton pregnancies and newborns from prenatal check-ups and deliveries at Guangdong Women and Children Hospital from 2017 to 2022. The subjects were grouped according to different GWG, and logistic regression was used to analyze the impact of GWG on adverse outcomes, including hypertensive disorders of pregnancy (HDP), gestational diabetes mellitus (GDM), large-for-gestational-age infants (LGA), small-for-gestational-age infants (SGA), and preterm births.ResultsAmong the 9058 participants included in the study, there were 438 cases (4.8%) of HDP, including 266 cases (2.9%) of gestational hypertension and 172 cases (1.9%) of preeclampsia. Additionally, there were 2018 cases (22.3%) of GDM; Among the adverse birth outcomes for newborns, the prevalence was 9.7% for SGA, 9.9% for LGA, 1.4% for early/mid-term preterm births, and 4.2% for late preterm births. After adjusting for confounding factors, the results showed that, excessive GWG was a risk factor for HDP (OR=1.829, P&lt;0.05) and LGA (OR=1.792, P&lt;0.05) compared to the normal gestational weight gain group. Insufficient GWG increased the risk of GDM (OR=2.203, P&lt;0.05), SGA (OR=1.474, P&lt;0.05) and was also a risk factor for early/mid-term preterm infants (OR=3.326, P&lt;0.05) and late preterm infants (OR=1.715, P&lt;0.05).ConclusionExcessive GWG is a risk factor for the occurrence of HDP and LGA, while insufficient GWG increases the risk of GDM, SGA and preterm infants (especially early/mid-term preterm infants). Therefore, it is recommended to strengthen the monitoring of weight changes during pregnancy in women of childbearing age, guide nutritional management during pregnancy, and keep GWG within a reasonable range to prevent adverse outcomes for mothers and infants.
Distribution and dynamics for the ecological assessment of Asan Wetland through periphyton -a water quality indicator
Authors: Tabassum Sazia , Kotnala C. B. , Dobriyal A. K. , Salman Mohammed , Bamola Richa 
Published: February 2025

The Asan Wetland is an important freshwater wetland in Uttarakhand’s Dehradun district. It is known for its diverse flora and fauna and as a stopover for migratory birds. Periphyton, an essential biological component of aquatic ecosystems, serves as a bioindicator of water quality and ecosystem integrity. This study fills a gap in our knowledge of the Asan Wetland’s ecological health by analyzing periphyton populations and a number of physicochemical characteristics across three selected sites from November 2021 to October 2023. Selected sites named as Site 1(S1), Site 2(S2), Site 3 (S3). Monthly variations in parameters such as water temperature, pH, turbidity, transparency, total dissolved solids (TDS), electrical conductivity, dissolved oxygen (DO), total hardness, alkalinity, biological oxygen demand (BOD), chemical oxygen demand (COD), and nutrients were collected, identified and assessed using Ms-excel and Past software. Phosphorus levels in the Asan Wetland indicated a moderate to high nutrient load, peaking in August (1.20–1.25 mg/L) across all three sites and dropping to their lowest in January (0.35–0.65 mg/L). Nitrate levels were moderate, with the highest concentrations in December (1.40–1.55 mg/L) and the lowest in July (0.25–0.35 mg/L), showing similar seasonal patterns across sites. The periphyton was represented in this study by 18 different periphytic taxa that belong to three different classes. These classes include Bacillariophyceae (Cymbella, Navicula, Nitzschia, Fragilaria Meridion, Synedra, Gomphonema, Tabellaria, and Diatoma), members of the Chlorophyceae Ulothrix, Spirogyra, Cosmarium, Microspora, Chlorella, Oedogomium, Zygnema, and Cladophora are, while Phormidium is a member of the Cyanophyceae. The peak periphytic density (individuals/cm2) recorded was 322.67 ± 89.08 × 103 in January, with all three classes exhibiting maximum values at S3, the minimum periphytic density (individuals/cm2) recorded was 18 ± 5.57 × 10³ in August. The annual percentage composition of periphytic flora in the Asan wetland over 2 years indicates that Bacillariophyceae constituted the predominant group (89%–90%), succeeded by Chlorophyceae (7%–9%) and Cyanophyceae or Myxophyceae (1%–4%) across three sites. The canonical correspondence analysis (CCA) of periphyton among different sites during both years of the study suggested that S3 was more diverse, followed by S1 and S2, represented 64.93%, 35.07% of the variance with eigenvalues of 0.01794, 0.00968 respectively. PCA suggested that PC1 and PC2 were represented by 93.98% and 6.015% of the variance with eigenvalues 279.149 and 17.8675, respectively The multivariate cluster analysis showed the similarity of periphyton at three different sites during the 2-year study. The findings of this study emphasize the need for targeted management strategies to maintain the ecological health of the Asan Wetland.
Clinical characteristics and management outcomes of pediatric patients with Coats disease complicated with retinoschisis (retinal cyst)
Authors: Liang Tingyi , Zhang Shaochi , Zhang Xiang , Wang Xiaohan , Ji Xunda , Zhao Peiquan 
Published: February 2025

PurposeTo present the clinical characteristics and management outcomes of Coats disease with retinoschisis (retinal cyst).MethodsThis was a retrospective review of 13 eyes from 13 consecutive Coats disease patients with retinal cyst. Clinical findings from multimodal ophthalmic imaging were recorded to characterize retinal cyst in Coats disease. All eyes were initially treated with endolaser photocoagulation combined with external drainage of cystic fluid and intravitreal ranibizumab injection. Patients were subsequently followed up to analyze anatomic and visual outcomes.ResultsAll retinal cysts were associated with extensive retinal exudation; 3 eyes (23.1%) presented with exudative retinal detachment. A total of 92.3% (12/13) of the retinal cysts were located in the inferotemporal quadrant. Fluorescein angiography demonstrated telangiectasia surrounding and/or at the edge of the retinal cyst. Eleven eyes (84.6%) underwent endolaser photocoagulation via a nonvitrectomy approach, and 2 eyes (15.4%) underwent endolaser photocoagulation after vitrectomy due to the presence of epiretinal membrane. An average of 1.5 additional laser photocoagulation sessions was performed per patient. After a median follow-up of 23 months (range, 11–33 months), all eyes demonstrated retinal cyst resolution and no active disease. Subretinal fibrosis was observed in 9 eyes (69.2%); of these, 8 had macular subretinal nodules. In total, 30.8% of the eyes had a final vision ≥20/200.ConclusionThe presence of retinoschisis (retinal cyst) in Coats disease is strongly associated with retinal telangiectasia and exudation and is indicative of active vascular disease requiring effective ablative treatment. We propose a novel approach, endolaser photocoagulation combined with external drainage of cystic fluid and intravitreal ranibizumab injection, which was effective in achieving final anatomic improvement with retinal cyst resolution.
Learning and working on an interprofessional training ward in neonatology improves interprofessional competencies
Authors: Schwarz Hannah L. , Straub Christine , Bode Sebastian F. N. , Ferschl Nicole , Brickmann Christian , Berberat Pascal O. , Krüger Marcus 
Published: February 2025

IntroductionInterprofessional education (IPE) is essential for healthcare professionals to prepare them for future interprofessional collaboration (IPC). Interprofessional training wards (ITWs) have been set up for IPE and results have been published. There are no published studies on ITWs in neonatology. We have designed and established the Interprofessional Training Ward in Neonatology (IPANEO) for nursing trainees (NT) and medical students (MS) in a neonatological intermediate care (IMC) ward. We report on the concept and the results with regard to the interprofessional competencies of the participants, including parent satisfaction.MethodsSupervision by medical and nursing learning facilitators, 2week blocks each with 2 NT (n = 30) and 2 MS (n = 23) in their final year, ward-in-ward concept, 3 patients cared for. Evaluation of the participants (pre/post) with the Interprofessional Socialisation and Valuing Scale (ISVS), the Interprofessional Collaboration Scale (ICS) with questions on IP communication, accommodation and isolation as well as with an IPANEO-specific evaluation (IPQ), an external evaluation with the “Observational Questionnaire for Learning Facilitators” (OQLF) and a “Questionnaire on Parent Satisfaction” (PSQ) (n = 33).ResultsIPANEO participants showed significant increases in competencies in IP communication, accomodation and isolation (ICS), a better IP-collaboration and a higher role definition (IPANEO specific questionnaire). The ISVS 9A/B global scores increased. According to the self-assessment there were significant improvements in the external evaluation in all IP-categories (OQLF). The feedback from the parents was significantly positive (PSQ).ConclusionInterprofessional learning and working on IPANEO had a positive impact on interprofessional competencies with high parent satisfaction.