bluuebunny/crossref_metadata_2025_split huggingface dataset:
Early Childhood Caries, Masticatory Function, Child Early Cognitive, and Psychomotor Development: A Narrative Review
Authors: Bramantoro Taufan , Mardiyantoro Fredy , Irmalia Wahyuning Ratih , Kristanti Risma Aprinda , Nugraha Alexander Patera , Noor Tengku Eleena Binti Tengku Ahmad , Fauzi Asra Al , Tedjosasongko Udijanto 
Published: December 2023

AbstractDental caries is known as a global public health issue that has been affecting general health apart from its painful nature. Hence, it is undeniable that caries affecting young children or known as early childhood caries, also have an effect on children's general health. One of the interesting findings about caries is that it can also affect child growth and development, specifically on their cognitive and psychomotor ability. Untreated caries are linked to cognitive development through both neural and vascular pathways, with masticatory function as the key. Meanwhile, its effect on psychomotor development might be related to nutritional intake, which might slightly decline on those with caries. This review is aimed to describe the current findings of caries effect on early child development, from masticatory disturbance to further impacts on cognitive and psychomotor development. The overall conclusion of this review is that untreated severe caries in children are potentially associated negatively with their growth and development.
Technical Success, Midterm Primary Patency, and Factors Affecting Primary Patency of Subintimal Angioplasty Followed by Vasculomimetic Stenting for Trans-Atlantic Intersociety Consensus II C and D Femoropopliteal Arterial Disease—A Prospective Study
Authors: Joseph Ansan , Valakkada Jineesh , Ayappan Anoop , Kannath Santhosh , Shivanesan Pitchai 
Published: December 2023

Abstract
Background The best option among the endovascular options in long, complex femoropopliteal (FP) lesions, and factors affecting the patency have yet to be well described. There are few studies describing the mid- and long-term patency of endovascular stents in long-segment FP occlusions.
Aim This study aimed to determine the technical success and mid-term patency of subintimal angioplasty with vasculomimetic stenting in Trans-Atlantic Inter-Society Consensus II (TASC) C and D FP disease. The patient and imaging factors that affect primary patency were also analyzed.
Methods and Materials A single-center prospective study was performed on 52 consecutive patients undergoing endovascular treatment for TASC C and D FP disease from 2017 to 2021. Angioplasty with stenting was performed in all patients and followed up for 36 months. Endpoints were primary patency rates and amputation-free survival of the limb. Kaplan–Meier curves were used to see patency rates and amputation-free survival rates.
Results A total of 52 patients underwent stenting with a technical success rate of 100% if the sub-intimal arterial flossing with antegrade-retrograde intervention (SAFARI) technique was used. Primary stent patency at 6, 12, 18, 24, and 36 months was 89.8, 81.4, 76.2, 71.4, and 62.5%, respectively. Amputation-free survival was 98, 95.6, 91.8, and 85.7% at 12, 24, 30, and 36 months, respectively. Cox proportional regression analysis showed smoking and vessel wall calcium score more than 270 degrees as independent predictors of loss of primary patency (hazard ratio 0.35 confidence interval [CI]: 0.003–0.448) and 0.102 (CI: 0.022–0.47), respectively.
Conclusion Subintimal angioplasty with vasculomimetic stent has good midterm patency in and amputation-free survival in long-segment FP occlusions. Smoking and severe vessel wall calcification adversely affect patency.
Cellular Components Contributing to the Development of Venous Thrombosis in Patients with Pancreatic Cancer
Authors: Willems Ruth Anne Laura , Biesmans Charlotte , Campello Elena , Simioni Paolo , de Laat Bas , de Vos-Geelen Judith , Roest Mark , ten Cate Hugo 
Published: December 2023

AbstractPancreatic ductal adenocarcinoma (PDAC) is an aggressive type of cancer and has a poor prognosis. Patients with PDAC are at high risk of developing thromboembolic events, which is a leading cause of morbidity and mortality following cancer progression. Plasma-derived coagulation is the most studied process in cancer-associated thrombosis. Other blood components, such as platelets, red blood cells, and white blood cells, have been gaining less attention. This narrative review addresses the literature on the role of cellular components in the development of venous thromboembolism (VTE) in patients with PDAC. Blood cells seem to play an important role in the development of VTE. Altered blood cell counts, i.e., leukocytosis, thrombocytosis, and anemia, have been found to associate with VTE risk. Tumor-related activation of leukocytes leads to the release of tissue factor-expressing microvesicles and the formation of neutrophil extracellular traps, initiating coagulation and forming a scaffold for thrombi. Tissue factor-expressing microvesicles are also thought to be released by PDAC cells. PDAC cells have been shown to stimulate platelet activation and aggregation, proposedly via the secretion of podoplanin and mucins. Hypofibrinolysis, partially explained by increased plasminogen activator inhibitor-1 activity, is observed in PDAC. In short, PDAC-associated hypercoagulability is a complex and multifactorial process. A better understanding of cellular contributions to hypercoagulability might lead to the improvement of diagnostic tests to identify PDAC patients at highest risk of VTE.
The generation of a fourth-harmonic probe and its application in Nomarski interferometry at Shengguang-II
Authors: Xu Guoxiao , Kang Ning , Cui Zijian , Liu Huiya , Lei Anle , Zhou Shenlei 
Published: December 2023

In this work, a design for the generation of a 4ω (263-nm) probe converted from a 1ω (1053-nm) laser is presented. The design is based on a beta-barium borate and potassium dihydrogen phosphate two-step frequency-conversion process. A suitable configuration for Nomarski interferometry based on the 4ω probe is proposed, for measuring the electron density of laser-produced plasmas. The signal-to-noise ratio of the output 4ω probe to 1ω and 2ω light after frequency quadrupling and harmonic separation is 103 with a 0.5 GW/cm2 1ω input but decreases to ∼102 at intensities below 0.1 GW/cm2. Additional noise suppression by a factor of 104 is achieved using filters before the interferometer recording camera. The spatial resolution of the diagnostic can reach 5.2 µm for a 10% modulation transfer function. An experiment validating the probe diagnostic system is conducted at the Shengguang-II laser facility. A clear interferogram of an aluminum plasma is obtained with 0.1 GW/cm2 input, suggesting a maximal electron density of about 2.5 × 1020 cm−3 as retrieved through an inverse-Abel transform. The design proposed in this paper is appropriate for a small laser device or a large laser facility that lacks a separate diagnostic beam, and it is an inexpensive solution as it requires small-aperture 1ω input at a relatively low intensity. All the key parameters necessary to implement the design are provided in detail, making it straightforward to reproduce or transplant the system for specific uses.
Elementary processes triggered in curcumin molecule by gas-phase resonance electron attachment and by photoexcitation in solution
Authors: Pshenichnyuk Stanislav A. , Asfandiarov Nail L. , Markova Angelina V. , Komolov Alexei S. , Timoshnikov Viktor A. , Polyakov Nikolay E. 
Published: December 2023

Electron-driven processes in isolated curcumin (CUR) molecules are studied by means of dissociative electron attachment (DEA) spectroscopy under gas-phase conditions. Elementary photostimulated reactions initiated in CUR molecules under UV irradiation are studied using the chemically induced dynamic nuclear polarization method in an acetonitrile solvent. Density functional theory is applied to elucidate the energetics of fragmentation of CUR by low-energy (0–15 eV) resonance electron attachment and to characterize various CUR radical forms. The adiabatic electron affinity of CUR molecule is experimentally estimated to be about 1 eV. An extra electron attachment to the π1* LUMO and π2* molecular orbitals is responsible for the most intense DEA signals observed at thermal electron energy. The most abundant long-lived (hundreds of micro- to milliseconds) molecular negative ions CUR– are detected not only at the thermal energy of incident electrons but also at 0.6 eV, which is due to the formation of the π3* and π4* temporary negative ion states predicted to lie around 1 eV. Proton-assisted electron transfer between CUR molecules is registered under UV irradiation. The formation of both radical-anions and radical-cations of CUR is found to be more favorable in its enol form. The present findings shed some light on the elementary processes triggered in CUR by electrons and photons and, therefore, can be useful to understand the molecular mechanisms responsible for a variety of biological effects produced by CUR.
Energy absorption and storage of nanofluidic solid–liquid composite material under high strain rates
Authors: Huang Wei , Feng Haiqi , Yu Lin , Xu Renduo , Liu Jiayi , Wang Yangwei 
Published: December 2023

Abstract
Efficient energy absorption and dissipation are crucial for the development of novel protective materials under intensive dynamic loadings. Nanofluidic solid–liquid composite materials (NLCs) provide a promising pathway to engineer such materials owing to their rapid and reversible energy absorption and storage performance. In this study, we conducted systematic experiments on nanoporous SiO2 based NLCs to gain a better understanding of the dynamic mechanical behavior and the underlying energy absorption and storage mechanisms under compressions with varying strain rates. Our findings indicate that the energy absorption in terms of dissipation and storage under the repeat compressive loadings includes two stages. The initial stage indicates the maximum energy absorption capacity, which is efficiently improved by the adding electrolyte solution and the retreatment. The stable energy absorbing stage represents the reversible energy absorption and storage capacity of the NLCs. Based on the noticeable strain rate effect, a three-stage mechanism is proposed to explain the significant increase of energy absorption capacity with the varying compressive strain rates. The superior reusable energy absorption capacity of NLCs holds great promise for their use as excellent energy-absorbing materials under intensive impulsive loadings.
Improved calculation of the Mie solution and the geometrical optics approximation for large droplets
Authors: Gabyshev Dmitrii N , Ganopolsky Rodion M 
Published: December 2023

Abstract
This article considers energy distribution of light inside a uniformly illuminated transparent water droplet. Two methods are used: the geometrical optics approximation and the Mie solution derived from wave optics. The authors describe in detail calculation algorithms suitable for efficient computer implementation and ways to improve them. In the limit for large droplets, both similarities and differences between the methods are pointed out. Resonant states are discussed, when the usually dark regions of the droplet turn out to be illuminated.
R&D of glass scintillator for nuclear radiation detection
Authors: Hua Z.H. , Qian S. , Cai H. , Chen D.P. , Du D.J. , Fan R.R. , Han J.F. , Hu P. , Li W.C. , Liu S. , Liu Y. , Ma L.S. , Qin L.S. , Ren J. , Sui Z.X. , Sun X.Y. , Tang G. , Wang Z.L. , Yang D. , Yin S.H. , Zhang M.H. , Zhu Y. 
Published: December 2023

Abstract
In 2021, the Institute of High Energy Physics proposed a design of glass scintillator coupled with SiPM as a new solution for the next generation calorimeter, to explore the application of glass scintillators in high energy physics and nuclear radiation detection. The Large Area Glass Scintillator Collaboration Group was established to research and develop a glass scintillator with high density, high light yields and fast decay time. Through continuous optimization, the glasses have excellent scintillation performance with a light yield of 1000 ph/MeV and a density of 6 g/cm3. Moreover, the neutron response of the glasses was investigated, and different high-energy particles can be distinguished by signal amplitude. In addition, the radiation resistance of different glasses was tested under proton beam. All the glasses appeared opaque and produced a high radioactive background, because Gd element interacts with proton to produce radionuclides with high activity and long half-life.
Sea level rise projections up to 2150 in the northern Mediterranean coasts
Authors: Vecchio A , Anzidei M , Serpelloni E 
Published: December 2023

Abstract
Vertical land movements (VLM) play a crucial role in affecting the sea level rise along the coasts. They need to be estimated and included in the analysis for more accurate Sea Level (SL) projections. Here we focus on the Mediterranean basin characterized by spatially variable rates of VLM that affect the future SL along the coasts. To estimate the VLM rates we used geodetic data from continuous global navigation satellite system stations with time series longer than 4.5 years in the 1996–2023 interval, belonging to Euro-Mediterranean networks and located within 5 km from the coast. Revised SL projections up to the year 2150 are provided at 265 points on a geographical grid and at the locations of 51 tide gauges of the Permanent Service for Mean Sea Level, by including the estimated VLM in the SL projections released by the Intergovernmental Panel on Climate Change (IPCC) in the AR6 Report. Results show that the IPCC projections underestimate future SL along the coasts of the Mediterranean Sea since the effects of tectonics and other local factors were not properly considered. Here we show that revised SL projections at 2100, when compared to the IPCC, show a maximum and minimum differences of 1094 ± 103 mm and −773 ± 106 mm, respectively, with an average value that exceeds by about 80 mm that of the IPCC in the reference Shared Socio-economic Pathways and different global warming levels. Finally, the projections indicate that about 19.000 km2 of the considered Mediterranean coasts will be more exposed to risk of inundation for the next decades, leading to enhanced impacts on the environment, human activities and infrastructures, thus suggesting the need for concrete actions to support vulnerable populations to adapt to the expected SL rise and coastal hazards by the end of this century.
On the capacity of a quantum perceptron for storing biased patterns
Authors: Benatti Fabio , Gramegna Giovanni , Mancini Stefano , Nwemadji Gibbs 
Published: December 2023

Abstract
Although different architectures of quantum perceptrons have been recently put forward, the capabilities of such quantum devices versus their classical counterparts remain debated. Here, we consider random patterns and targets independently distributed with biased probabilities and investigate the storage capacity of a continuous quantum perceptron model that admits a classical limit, thus facilitating the comparison of performances. Such a more general context extends a previous study of the quantum storage capacity where using statistical mechanics techniques in the limit of a large number of inputs, it was proved that no quantum advantages are to be expected concerning the storage properties. This outcome is due to the fuzziness inevitably introduced by the intrinsic stochasticity of quantum devices. We strengthen such an indication by showing that the possibility of indefinitely enhancing the storage capacity for highly correlated patterns, as it occurs in a classical setting, is instead prevented at the quantum level.
Political Biography and the Agency of Audience
Authors: Bjerk Paul 
Published: December 2023

Abstract
Development as Rebellion, the massive biographical study of Julius K. Nyerere, written by three leading Tanzanian scholars and published in 2020 by the august Dar es Salaam imprint Mkuki na Nyota, illustrates how authors and audience are entangled in discursive practice. Jacques Derrida’s postmodern concept of iterability suggests that any message, let alone a nationalist biography, never exists in a stable univocal state, but that its meaning takes form, continually mutating, in an interactive social context between author and audience. It is not merely that the authors address an audience imprinted with the intellectual traditions known as the “Dar es Salaam School” of the University of Dar es Salaam; they engage not just the concerns of that audience, of which they are themselves members, but their priorities and categories of thought. This essay offers a review of Development as Rebellion as evidence for a theoretical argument about how an audience shapes the composition of a piece of writing, and how this helps us address the ongoing debate about the way scholarly authority in African studies tends to reside outside Africa. Addressing this circumstance must begin counterintuitively with questions about the audience of Africanist scholarship rather than its authors.
Endemic Goiter and El Salvador’s Battle Against Cretinismo
Authors: Vrana Heather 
Published: December 2023

Abstract
One concern for Salvadoran and other Latin American public health researchers across the nineteenth and twentieth centuries was the purported link between goiter (bocio) and cretinism (cretinismo). Goiter is empirical medical condition that is inseparable from scenes of social and political inequality, neocolonialism, development, and war, however effectively the tools that measured it often obfuscated these factors. This article draws on more than a century of goiter research and representation in popular culture to argue that goiter research was part of broader health discourse that focused on poor and rural women and girls in an attempt to improve the productive and reproductive potential of El Salvador. It discusses how goiter research positioned El Salvador as a site of knowledge production for global health. It also proposes that goiter is best understood as a disability and uses insights from critical disability studies to understand how certain groups of people were constructed as problem populations. Over time, understandings of goiter shifted and new explanations came to the fore, but the lingering association of goiter with inheritable disability proved difficult to shake.
“As [Healthy] Women Should”
Authors: Blumenthal Debra 
Published: December 2023

Abstract
Expanding the discussion highlighting the role of slavery in the production of medical knowledge beyond the much more extensively studied Atlantic world and the nineteenth-century US South, this article explores the exploitation of enslaved women’s bodies as clinical subjects in fifteenth-century Iberia. Menstrual disorders figured prominently among “hidden defects” cited in slave warranty suits filed by disgruntled buyers across the late medieval Mediterranean world. Reflective of their heightened interest in female physiology during this period, university-trained male physicians were the expert witnesses most frequently called on to resolve disputes concerning what an enslaved woman’s lack of menses meant. Through a close analysis of “expert” testimony in seven lawsuits filed before the court of the Justicia Civil in Valencia in the 1440s, the slave market emerges as a site offering unparalleled opportunities for physicians to directly touch and probe female genitalia. Insofar as they could be poked and prodded with relative impunity, the bodies of enslaved women bought and sold in late medieval Mediterranean markets were instrumental to the expansion of learned gynecological knowledge.
Review Article: Gastroenterology and Clostridium difficile Infection: Past, Present, and Future
Authors: Kelly Colleen R , Allegretti Jessica R 
Published: December 2023

Abstract
Research and innovation around Clostridium difficile infection (CDI) has been a multidisciplinary endeavor since discovery of the organism in 1978. The field of gastroenterology has contributed to our understanding of CDI as a disease caused by disruptions in the gut microbiome and led to advances in therapeutic manipulation of gut microbiota, including fecal microbiota transplantation. The high incidence of CDI in patients with inflammatory bowel disease and treatment of the infection in this population have been of particular interest to gastroenterologists. The emergence of standardized, approved live biotherapeutic products for treatment of recurrent CDI is an inflection point in our management of this difficult clinical problem, and real-world performance of these therapies will inform optimal treatment algorithms.
Dual function of fungi-derived cytokines in inflammatory bowel diseases: protection or inflammation
Authors: Sharifinejad Niusha , Mahmoudi Elaheh 
Published: December 2023

Abstract
Inflammatory bowel disease (IBD) is an immune-mediated inflammatory condition involving both the innate and adaptive immune systems. Recently, the role of intestinal fungal flora and their downstream immune pathways has been highlighted in the pathogenesis of IBD. Cytokines as primary immune mediators require a delicate balance for maintaining intestinal homeostasis. Although most cytokines have a predictable role in either amplifying or attenuating inflammation in IBD, a few cytokines have shown a dual function in the inflammatory state of the intestine. Some of these dual-faced cytokines are also involved in mucosal anti-microbial defense pathways, particularly against intestinal fungal residents. Here, we reviewed the role of these cytokines in IBD pathogenesis to achieve a better understanding of the fungal interactions in the development of IBD.
Association between adjuvant chemotherapy and survival in stage I gastric cancer patients after curative resection
Authors: Chen Qiuying , Xiao Hua , Zhang Lu , You Jingjing , Jin Zhe , Zhang Bin 
Published: December 2023

Abstract

Background
The efficacy of adjuvant chemotherapy (AC) on survival outcomes of patients with stage I gastric cancer (GC) after curative resection remains controversial. We aimed to determine whether these patients would benefit from AC.

Methods
This retrospective study included patients with pathologically confirmed stage I GC who underwent curative resection between November 2010 and December 2020. Patients were divided into AC and non-AC groups, then a 1:1 propensity score matching (PSM) analysis was performed to minimize the selection bias. Potential risk factors including age, pN stage, pT stage, lymphovascular invasion, perineural invasion, tumor size, histological type, and carcinoembryonic antigen level were used as matching covariates. The recurrence-free survival (RFS) and disease-specific survival (DSS) were compared between groups using the Kaplan–Meier method.

Results
A total of 902 consecutive patients were enrolled and 174 (19.3%) patients were treated with AC. PSM created 123 pairs of patients. Before PSM, patients receiving AC had lower 10-year RFS rates (90% vs 94.6%, P = 0.035) than those who did not receive AC; the two groups had similar 10-year DSS rates (93.8% vs 95.0%, P = 0.240). After PSM, there were no statistical differences in the 10-year RFS (90.9% vs 93.0%, P = 0.507) or DSS rates (93.5% vs 93.6%, P = 0.811) between the two groups. Similar results were found in the stage IA and IB subgroups. Moreover, these findings were not affected by AC cycles.

Conclusions
The addition of AC could not provide survival benefits for patients with stage I GC after surgery and follow-up is thus recommended. However, large-scale randomized clinical trials are required.