bluuebunny/crossref_metadata_2025_split huggingface dataset:
Genome-wide association studies on coronary artery disease: A systematic review and implications for populations of different ancestries
Authors: Silva Sarah , Nitsch Dorothea , Fatumo Segun 
Published: November 2023

Background
Cardiovascular diseases are some of the leading causes of death worldwide, with coronary artery disease leading as one of the primary causes of mortality in both the developing and developed worlds. Despite its prevalence, there is a disproportionately small number of studies conducted in populations of non-European ancestry, with the limited sample sizes of such studies further restricting the power and generalizability of respective findings. This research aimed at understanding the differences in the genetic architecture of coronary artery disease (CAD) in populations of diverse ancestries in order to contribute towards the understanding of the pathophysiology of coronary artery disease.

Methods
We performed a systematic review on the 6th of October, 2022 summarizing genome-wide association studies on coronary artery disease, while employing the GWAS Catalog as an independent database to support the search. We developed a framework to assess the methodological quality of each study. We extracted and grouped associated single nucleotide polymorphisms and genes according to ancestry groups of participants.

Results
We identified 3100 studies, of which, 36 relevant studies were included in this research. Three of the studies that were included were not listed in the GWAS Catalog, highlighting the value of conducting an independent search alongside established databases in order to ensure the full research landscape has been captured. 743,919 CAD case participants from 25 different countries were analysed, with 61% of the studies identified in this research conducted in populations of European ancestry. No studies investigated populations of Africans living in continental Africa or admixed American ancestry groups besides African-Americans, while limited sample sizes were included of population groups besides Europeans and East Asians. This observed disproportionate population representation highlights the gaps in the literature, which limits our ability to understand coronary artery disease as a global disease. 71 genetic loci were identified to be associated with coronary artery disease in more than one article, with ancestry-specific genetic loci identified in each respective population group which were not detected in studies of other ancestries.

Conclusions
Although the replication and validation of these variants are still warranted, these finding are indicative of the value of including diverse ancestry populations in GWAS reference panels, as a more comprehensive understanding of the genetic architecture and pathophysiology of CAD can be achieved.
Changes in food purchase, consumption and handling during COVID-19 pandemic among single person households
Authors: Antwi Janet , Olawuyi Yetunde , Bain Shadiamon , Samuel Kyndall 
Published: November 2023

Objective
As a new type of consumer subject in the market that was formerly dominated by multiple person families, single households are driving the change in the buying structure. Food purchase activities have undergone significant changes since the outbreak of the COVID‐19. The objective of this study was to assess and compare variations in food consumption, purchase and handling during the COVID-19 pandemic between single person households (SPH) and multiple person households.

Method
A cross-sectional study conducted among 211 individuals in communities in Harris and Waller Counties, Texas. Sociodemographic, food purchase, food consumption and food handling activities during the COVID-19 pandemic were assessed with a validated COVID-19 Nutrition questionnaire.

Results
Non-Hispanic Black participants constituted 42.6%, and 28.4% were Hispanics. Participants were made up of mostly aged 18–24 years (39.3%), 47.9% single household composition, 30.4% in full time employment, and 29.1% partook in food assistance programs. A large proportion of them had never used grocery pickup services, online grocery shopping and a farmers’ market. During the COVID-19 pandemic, majority of the participants used more of large supermarkets, restaurant/fast food, and online grocery but food consumption seemed to remain the same for the majority of participants. For beverages, majority of participants consumed more water, less soda, and no alcohol. There was a significant association between single person household and higher restaurant/fast foods purchase. Many of the participants reported weight gain and less physical activity during the pandemic.

Conclusion
Restaurant meal purchases was more prevalent in single-person families. The results from the study have the potential to contribute to how public policy officials, food service, and health authorities forecast how different categories of consumers will react in pandemics and may be used to inform area-specific alleviation strategies to minimize the impact of the COVID-19 pandemic and future events.
The development and the use of gender-affirming online resources and games for gender-independent, intersex, non-binary, and transgender (GIaNT) children and youth: A scoping review protocol
Authors: Haghiri-Vijeh Roya , Newman-Seymour Kat , Huizenga Daniel , Hung Aidan 
Published: November 2023

Objective
The objective of this scoping review protocol is to review what has been reported on the development and the use of gender-affirming online resources and games for gender-independent, intersex, non-binary, and transgender (GIaNT) youth (aged 9–26).

Introduction
GIaNT youth and their specialized health care needs are mostly exempt from curriculums. There is limited information on the specific online sources available for GIaNT children and youth.

Inclusion criteria
The inclusion criteria are sources that include GIaNT children and youth and focus on online spaces and games for the identified population.

Methods
The Joanna Briggs Institute (JBI) method for scoping reviews has guided the development of this protocol. Databases to be searched include CINAHL, Cochrane, Epistemonikos, ERIC, Gender Studies Database, GenderWatch, LGBTQ+ Source, ProQuest, PyscInfo, and Scopus. Unpublished studies and gray literature searches will be undertaken in ProQuest thesis and dissertation and a limited number of relevant websites. No limit on date or region will be applied. Records will be screened and extracted by two independent reviewers. Results will be presented as tables with accompanying narrative summary.

Conclusion
This scoping review protocol will guide the review and mapping of literature on available sources for online spaces and games for GIaNT children and youth.
The association between serum prolactin levels and live birth rates in non-PCOS patients: A retrospective cohort study
Authors: Xu Xiaoyuan , Yang Aimin , Han Yan , Wang Wei , Hao Guimin , Cui Na 
Published: November 2023

Background and objectives
This paper aimed to analyze the relationship between baseline prolactin (PRL) levels and live birth rates (LBRs) in patients undergoing embryo transfer who did not have polycystic ovarian syndrome (PCOS) using a retrospective design. Patient(s): A total of 20,877 patients who had undergone IVF/intracytoplasmic sperm injection (ICSI) between December 2014 and December 2019.

Materials and methods
We examined the association between PRL concentrations and LBRs using multivariate regression analysis. In addition, a model for nonlinear relationships based on a two-part linear regression was developed.

Results
Following adjustment for confounding factors, multivariate regression analysis confirmed a statistically significant correlation between serum PRL and LBR. Particularly, when blood PRL content was less than 14.8 ng/mL, there exists a positive relation between serum PRL and LBRs. In contrast, once PRL concentrations surpassed the inflection point at 14.8 ng/mL, a meaningful relationship could no longer be inferred between serum PRL and LBR.

Conclusions
Basal serum PRL levels were segmentally connected with LBRs.
DEVELOPMENT OF THE ONE-STEP METHOD FOR PRODUCING ALLOBETULIN FROM BIRCH BARK AND STUDY OF ITS ANTIOXIDANT ACTIVITY
Authors: Skurydina Yevgeniya Sergeyevna , Vasil'yeva Natal'ya Yur'yevna , Kuznetsova Svetlana Alekseyevna , Titova Nadezhda Mitrofanovna , Kuznetsov Boris Nikolayevich 
Published: November 2023

Birch bark contains extractive substances of the lupan types that have pharmacological activity and are of interest for obtaining new medicines. The predominant component of external birch bark extracts is pentacyclic triterpene alcohol - betulin. Allobetulin (19,28-epoxy-oleanan-3-ol) is an isomer of betulin and belongs to the pentacyclic triterpenoids of the oleanane types. Allobetulin and its derivatives are non-toxic compounds and they have antiviral, antimicrobial and antitumor activities. A new one-step method for producing allobetulin directly from birch bark by combining the stages of betulin extraction with ethanol and its isomerization into allobetulin in the presence of phosphoric acid catalyst was developed. The effect of the duration of birch bark treatment with ethanol and H3PO4 content on the yield of allobetulin was esteblished. The highest yield of crude allobetulin (35% by weight of a.s.b.) is achieved at a process duration of 8 hours in the presence of 5% H3PO4 and also at a duration of 15 hours in the presence of 3% H3PO4. The yield of recrystallized allobetulin is about 22% of the weight of absolutely dry birch bark.
The composition of the allobetulin sample after recrystallization from isopropanol was confirmed by elemental analysis and its structure by – IRS and 1H NMR methods.
The antioxidant properties of allobetulin were established in vivo and in vitro experiments.
Simulating the alteration in energy consumption at a zebra crossing considering different traffic rates of electric and rule-following autonomous vehicles
Authors: Szigeti Szilárd , Földes Dávid , Ye Xin 
Published: November 2023

The progressive integration of autonomous vehicle (AV) technology holds the potential to reshape the prevailing traffic landscape. AVs have different driving characteristics than human-driven vehicles, which manifests itself in the strict adherence to speed limit, in giving priority to pedestrians, and in the pre-set headways they can keep. A traffic simulation environment was built around an unsignalized pedestrian crossing to measure the energy consumption of vehicles in the presence of AVs. The simulation environment was modified to adhere pedestrian-accepted gaps between vehicles in case of crossing. Considered vehicle types are yielding or not yielding human-driven, and AVs. Scenarios were built to model the AV traffic share, the different headways kept by AVs, and the various traffic volumes in each direction. The different driving behaviour and traffic share of AVs led to energy consumption changes, which were modelled through scenario analysis. The maximum energy consumption reduction of human-driven vehicles was 10.67% for yielding vehicles and 12.41% for non-yielding vehicles compared to the 0% AV traffic rate. Although, in case of AVs, the energy consumption increased in all scenarios compared to the basic version with only human-driven vehicles. In higher traffic scenarios, where only AVs were on the road, there was a substantial 35,92-96.55% increase in energy consumption, compared to the 0% AV ratio case. Thereby speed of vehicles, following distance and the number of stops affected the overall system efficiency. The results of this study can contribute to the understanding the impact of AVs which can support their introduction.
The (p,q)-sine and (p,q)-cosine polynomials and their associated (p,q)-polynomials
Authors: Husain Saddam , Khan Nabiullah , Usman Talha , Choi Junesang 
Published: November 2023

AbstractThe introduction of two-parameter(p,q){(p,q)}-calculus and Lie algebras in 1991 has spurred a wave of recent research into(p,q){(p,q)}-special polynomials, including(p,q){(p,q)}-Bernoulli,(p,q){(p,q)}-Euler,(p,q){(p,q)}-Genocchi and(p,q){(p,q)}-Frobenius–Euler polynomials. These investigations have been carried out by numerous researchers in order to uncover a wide range of identities associated with these polynomials and applications. In this article, we aim to introduce(p,q){(p,q)}-sine and(p,q){(p,q)}-cosine based λ-array type polynomials and derive numerous properties of these polynomials such as(p,q){(p,q)}-integral representations,(p,q){(p,q)}-partial derivative formulae and(p,q){(p,q)}-addition formulae. It is worth noting that the utilization of the(p,q){(p,q)}-polynomials introduced in this study, along with other(p,q){(p,q)}-polynomials, can lead to the derivation of various identities that differ from the ones presented here.
Case report of atypical undernutrition of hypoproteinemia type
Authors: Wang Qun-Ru , Long Jun , Wang Chen-Cheng , Hu Ji-Lei , Lin Ning , Tang Shan-Hong 
Published: November 2023

Abstract
Albumin and prealbumin serve as vital markers reflecting hepatic synthesis activity and overall body nutrient status. Hypoproteinemia can result from various etiological factors, with reduced blood inflow into the liver due to portal vein thrombosis being one such cause. However, literature addressing this specific association remains limited. This report presents an atypical case of malnutrition involving a patient who experienced prolonged hypoproteinemia attributable to a gradual decline in hepatic blood perfusion caused by progressive portal thrombosis and cavernous transformation of the portal vein (CTPV). The case encompasses an in-depth analysis of the factors contributing to undernutrition, the etiology and diagnosis of hypoproteinemia, and its clinical implications. Vigilance for the presence of hypoproteinemia is essential in the management of patients afflicted by progressive portal vein thrombosis complicated by CTPV. Timely and effective interventions aimed at rectifying hypoproteinemia can significantly enhance clinical outcomes. Moreover, reduced hepatic blood flow should be considered a plausible underlying cause in cases of unexplained hypoproteinemia, warranting thorough evaluation. This case underscores the importance of recognizing the intricate interplay between hepatic vascular pathology and protein homeostasis in clinical practice.
Alternation in the Mandarin disposal constructions: quantifying their evolutionary dynamics across twelve centuries
Authors: Liu Meili , Cuyckens Hubert 
Published: November 2023

Abstract
Despite extensive research on the ba-construction in Chinese, the diachronic change in the alternation between the ba and jiang constructions has received little attention. The present study takes a multifactorial approach to examine the factors that probabilistically condition the alternation based on diachronic data across twelve centuries. The results suggest two general trends. First, the odds of the ba-construction have increased over time at the expense of the jiang-construction. Second, over time, the effect size of the significant preference for the jiang-construction in informal genres has reduced from the 10th to the 19th century, and this preference has disappeared in modern times; accordingly, both informal and formal genres have converged to favor the ba-construction in modern times. Regression modeling also shows that there are both stable linguistic constraints (parallelism/syntactic priming, verb type, NP2 animacy, and NP2 length) and fluid constraints (adjunct semantics, and genre). This study advances our knowledge of the two disposal constructions and their evolution, sheds light on the Principle of No Synonymy (Bolinger, Dwight. 1977. Meaning and form. New York: Longman; Goldberg, Adele E. 1995. Constructions: A construction grammar approach to argument structure. Chicago: The University of Chicago Press; Goldberg, Adele E. 2002. Surface generalizations: An alternative to alternations. Cognitive Linguistics 13(4). 327–356), and makes a methodological contribution to the empirical testing of hypotheses. It can also provide insight into grammatical alternations in Mandarin.
Metacognition and diagrams in marking-for-self
Authors: Perissinotto Henrique T. D. , Queiroz João 
Published: November 2023

AbstractMetacognition relies on representations, which are commonly viewed as internal knowledge structures. We explore the idea that external embodied diagrams, rather than monomodal symbolic-based entities, can provide an accurate description of metacognition in choreographic dance. When marking, dancers use their bodies to represent properties, dynamics, or structures of dance phrases. Marking-for-self occurs when a dancer marks the dance in their own unique manner, potentially allowing for real-time reflection through the manipulation of external signs. These manipulations can be considered diagrammatic semiosis, as diagrams signify shared relational parts analogous to the parts of their objects. Based on Peirce’s semiotics, we argue that semiosis is crucial for metacognition. This paper is structured to first review marking and marking-for-self, followed by an overview of metacognition. We then define marking-for-self as a metacognitive phenomenon and introduce Peirce’s concept of semiosis and diagrams. Finally, we describe marking as a diagrammatic sign and explain how marking-for-self is an embodied metacognitive process achieved through the manipulation of diagrammatic structures.
Beyond anaphoric and emphatic: diversity and unity in the functions of literary Chinese reflexive zì
Authors: Lai Ryan Ka Yau 
Published: November 2023

Abstract
In this paper, I examine the Literary Chinese reflexive zì, which exhibits a crosslinguistically uncommon pattern: it performs both anaphoric and emphatic uses in adverbial position. I show that it has several uses: signalling coreference between the subject and the object, the object’s possessor or the topic or focus of a complement clause, emphasising that the subject’s identity, and indicating that the event affected the subject itself or had no external cause. I argue against categorically dividing these uses into anaphoric and emphatic uses. I propose four properties to unify the various uses: the referent of zì is centrally relevant to the event denoted by the predicate, coreferential with the subject, unexpected in its role in the event, and often contrasts with an alternative referent that may play same role. I compare my account to properties of reflexives in other languages, and argue that zì only partially supports Levinson’s (Levinson, Stephen C. 1991. Pragmatic reduction of the binding conditions revisited. Journal of Linguistics 27(1). 107–161) theory of the development of anaphoric reflexives from emphatics.
Some Betti numbers of the moduli of 1-dimensional sheaves on ℙ2
Authors: Yuan Yao 
Published: November 2023

Abstract
Let

M
⁢

(
d
,
χ
)

{M(d,\chi)}

, with

(
d
,
χ
)

=
1

{(d,\chi)=1}

, be the moduli space of semistable sheaves on

ℙ
2

{\mathbb{P}^{2}}

supported on curves of degree d and with Euler characteristic χ. The cohomology ring

H
*

⁢

(

M
⁢

(
d
,
χ
)

,
ℤ
)

{H^{*}(M(d,\chi),\mathbb{Z})}

of

M
⁢

(
d
,
χ
)

{M(d,\chi)}

is isomorphic to its Chow ring

A
*

⁢

(

M
⁢

(
d
,
χ
)

)

{A^{*}(M(d,\chi))}

by Markman’s result. Pi and Shen have described a minimal generating set of

A
*

⁢

(

M
⁢

(
d
,
χ
)

)

{A^{*}(M(d,\chi))}

consisting of

3
⁢
d

-
7

{3d-7}

generators, which they also showed to have no relation in

A

≤

d
-
2

⁢

(

M
⁢

(
d
,
χ
)

)

{A^{\leq d-2}(M(d,\chi))}

. We compute the two Betti numbers

b

2
⁢

(

d
-
1

)

{b_{2(d-1)}}

and

b

2
⁢
d

{b_{2d}}

of

M
⁢

(
d
,
χ
)

{M(d,\chi)}

, and as a corollary we show that the generators given by Pi and Shen have no relations in

A

≤

d
-
1

⁢

(

M
⁢

(
d
,
χ
)

)

{A^{\leq d-1}(M(d,\chi))}

,
but do have three linearly independent relations in

A
d

⁢

(

M
⁢

(
d
,
χ
)

)

{A^{d}(M(d,\chi))}

.
On λ-statistically φ-convergence
Authors: Choudhury Chiranjib , Debnath Shyamal , Savaş Ekrem 
Published: November 2023

Abstract
In this paper, by using the notions of λ-density,

(
V
,
λ
)

{(V,\lambda)}

-summability and Orlicz function ϕ, we introduce a new concept of convergence, namely λ-statistically ϕ-convergence, as a generalization of the λ-statistical convergence and statistically ϕ-convergence. Based on this concept, we introduce a new sequence space

S
λ

-
ϕ

{S_{\lambda}-\phi}

and investigate some of its properties. Also, we find its relations with statistically ϕ-convergence,

[
C
,
1
]

ϕ

{[C,1]_{\phi}}

-summability and

[
V
,
λ
]

ϕ

{[V,\lambda]_{\phi}}

-summability.
Finally, we introduce and investigate the concept of

S
λ

-
ϕ

{S_{\lambda}-\phi}

Cauchy sequences.
Ultrafast dynamics and ablation mechanism in femtosecond laser irradiated Au/Ti bilayer systems
Authors: Lian Yiling , Jiang Lan , Sun Jingya , Tao Wenpan , Chen Zhicheng , Lin Gen , Ning Ziqian , Ye Manlou 
Published: November 2023

Abstract
The significance of ultrafast laser-induced energy and mass transfer at interfaces has been growing in the field of nanoscience and technology. Nevertheless, the complexity arising from non-linear and non-equilibrium optical-thermal-mechanical interactions results in intricate transitional behaviors. This complexity presents challenges when attempting to analyze these phenomena exclusively through modeling or experimentation. In this study, we conduct time-resolved reflective pump-probe imaging and molecular-dynamics coupled two-temperature model (MD-TTM) simulations to investigate the ultrafast dynamics and ablation mechanism of Au/Ti bilayer systems. The calculated energy absorption curves indicate that Au film reduces the energy deposition in the underlying Ti layer, resulting in reduced melting and evaporation rate of Ti. The phase transition process induces different mechanical responses. The potential energy patterns indicate that the expansion of vapor Ti extrudes the surface Au layer outward. In simulated stress distribution images, the Au layer can hamper the expansion of the vapor-phase Ti and brings dynamic compressive stress to the residual Ti layer. When the compressive stress transforms into tensile stress, the material is removed through mechanical damage. Therefore, both Au and Ti in the 20 nm Au-covered Ti are completely removed. Our approach elucidates the ablation mechanism within the Au/Ti bilayer system and offers fresh insights into managing thermo-mechanical responses within analogous systems.
Revisiting the binary view of honorifics in politeness research
Authors: Kádár Dániel Z. , House Juliane , Todo Keiko , Xiao Tingting 
Published: November 2023

Abstract
In this paper, we revisit the popular assumption that politeness in languages such as Japanese and Korean with a complex honorific system is crucially different from politeness in languages with no comparably rich honorific repertoires, such as Chinese. We propose a bottom–up, contrastive and corpus-based model through which we challenge this binary view. This model combines interaction ritual and speech acts. As a case study, we compare a set of expressions representing lexico-grammatical honorifics in Japanese and Chinese, i.e., in a so-called “honorific-rich” and a “non-honorific-rich” language. Our results show that the group of honorifics studied work in an essentially comparable fashion, hence disproving the above-outlined binary view.