bluuebunny/crossref_metadata_2025_split huggingface dataset:
Energy storage density and efficiency of polyetherimide nanocomposites diminished by the temperature dependent charge hopping
Authors: Wang Poxin , Min Daomin , Wang Shihang , Zhang Yuanshuo , Liu Wenfeng , Wu Qingzhou 
Published: December 2023

AbstractThe utilization of renewable energies requires extensive use of energy storage equipment such as dielectric capacitor. Polyetherimide nanocomposites (PEI PNCs) have high energy storage performance, and become the next generation advanced dielectrics However, the quantitative relation between the charge transport and energy storage of PEI PNCs is not very clear, restricting further improvement of their performance. Considering the charge injection from electrodes and the charge hopping transport inside the dielectric, the energy storage and release model of capacitors was established. Firstly, the conductivities of PEI PNCs were simulated, and the charge transport parameters were determined by comparing with the experiments. Then, the electric displacement‐electric field (D‐E) loops of PEI PNCs were simulated, and the discharged energy density and energy efficiency were calculated from them. The simulation results are consistent with the experiments, and the quantitative relationship between charge injection and transport parameters and energy storage performance is established. In addition, it is found that the energy storage density and efficiency are diminished by the increase of hopping distance at high temperatures. Increasing the hopping barrier, reducing the hopping distance and its temperature dependence through nano‐doping can significantly improve the energy storage performance under high temperatures and high electric fields.
Pro‐aromatic Dihydroquinazolinones – From Multigram Synthesis to Reagents for Gram‐scale Metallaphotoredox Reactions
Authors: Tsai Zong‐Nan , Li Li‐Yun , Paculba Aira Shayne , Miñoza Shinje , Tsao Yong‐Ting , Lin Pei‐Shan , Liao Hsuan‐Hung 
Published: December 2023

AbstractDihydroquinazolinone (DHQZ) has recently been harnessed as a ketone‐derived pro‐aromatic reagent extensively employed in (metalla)photoredox reactions as versatile group transfer agents. In this work, we outline a column chromatography‐free protocol for the multigram‐scale synthesis of pro‐aromatic DHQZs as well as its use in a gram‐scale nickel/photoredox dual‐catalyzed cross‐coupling in single‐batch, photoflow, and simultaneous multiple smaller batches. While the single‐batch approach leveraged moderate yields, a simple plug‐flow photoreactor also exhibited amenable productivity (up to 45 % yield) despite the use of a heterogeneous base. Meanwhile, performing the metallaphotoredox‐catalyzed reaction in multiple smaller batches in an improvised photoreactor facilitated high yields of up to 59 % and good reproducibility, implying a convenient alternative in the absence of photoflow setups.
Biofuels, environment, and food security in Africa
Authors: Subramaniam Yogeeswari , Al‐Mulali Usama 
Published: December 2023

AbstractIn recent years global hunger has increased across the world. Africa is the main contributor to this and more people in Africa are affected by undernourishment. This issue is likely to be exacerbated by the rapid development of the biofuels industry across the globe. However, it would be very strange to conclude that the production of biofuels should be neglected given that biofuels are intended to preserve the quality of the environment. Hence, the objective of this study is to search for a win‐win solution between biofuels and food security. Dynamic generalized method of moments results indicate that biofuels will have a positive effect on food security if their production can also promote environmental quality, which is favorable to crop production. Thus, it indicates that the significant expansion and consumption of biofuels could contribute to increasing food security and sustaining environmental quality.
Usefulness of three vessel‐trachea view and parasagittal plan for prenatal diagnosis of interrupted aortic arch
Authors: Monteiro Sidonie , Cunha Ana , Sá Diogo Carvalho , Guedes‐Martins Luís 
Published: December 2023

AbstractBackgroundInterrupted aortic arch (IAA) is a rare congenital heart disease characterized by loss of continuity between the ascending and the descending aorta. Prenatal diagnosis of IAA by echocardiography is challenging but nonetheless can be accomplished via a systematization of cardiac fetal evaluation.Case PresentationWe report a case of fetal IAA type A prenatally diagnosed through two‐dimensional echocardiography using both a three vessel‐trachea view and a sagittal view.ConclusionPrenatal counseling regarding the diagnosis and prognosis about this anomaly is still challenging nowadays due to associated anomalies/chromosomal abnormalities who may impact the prognosis. Fetal autopsy in all cases of pregnancy termination after abnormal ultrasound findings is important in order to make a full diagnosis and characterize the anomaly.
Students’ perceptions of online education: A session at the FAOBMB–IUBMB–CBSL virtual education symposium 2021
Authors: Doluweera Minul , Kirihene Kiriheneappuhamilage Don Harindu Kusaljith , Indika Neluwa‐Liyanage Ruwan , Sirisena Channa Nirmal , Jatunarachchi Asel Helitha , Chandrasena Uthkarsha , Dharmadasa Senumi Gihansa , Samaranayake Amali , Devendra Vonara Gatharie , Edirisinghe Vinudi Nimethma , Sugandhika Suresh Thusharie , Jayasena Sharmila , Yu Gracia Fe Budoy , Pastor Crist John , Thoradeniya Tharanga 
Published: December 2023

AbstractThe Federation of Asian and Oceanian Biochemists and Molecular Biologists (FAOBMB) and the College of Biochemists of Sri Lanka (CBSL) organized a virtual education symposium in 2021 funded by the International Union of Biochemistry and Molecular Biology (IUBMB). The parallel session named “Students’ Perception” was attended by 188 participants from 11 countries. The main objectives of this session were to aggregate participants’ viewpoints on aspects of virtual education, including innovative strategies to enhance motivation and engagement of students, improving teacher–student and student–student interactions, managing stress, and virtual learning platforms. Data were collected via rapporteurs from multiple segments of the session including a mini‐introductory talk, poll, role play, and discussions about outstanding student experiences, types of virtual platforms, innovative methods of teaching, student motivation and stress management. The importance of student perception and issues like technological difficulties and the reluctance of students to engage were discussed. In addition to well‐established strategies such as using polls, chat box features, and discussions in breakout rooms, participants also proposed exciting learning methods to engage students such as quizzes, competitions and challenges, engagement of multiple sensory modalities, story‐based learning, and so forth. This report provides anecdotal evidence on pedagogies described in textbooks and also introduces new ideas based on this existing foundation. Future research should aim to harmonize virtual education with traditional classroom methods and explore innovative virtual tools like avatar‐based universities, virtual labs, and user‐friendly online assessment platforms. The results apply to all disciplines, and not exclusively to biochemistry and molecular biology (BMB).
Antidiabetic Potential of a Trimeric Anthranilic Acid Peptide Isolated from Malbranchea flocciformis
Authors: Rebollar‐Ramos Daniela , Ovalle‐Magallanes Berenice , Raja Huzefa A. , Jacome‐Rebollo Mariano , Figueroa Mario , Tovar‐Palacio Claudia , Noriega Lilia G. , Madariaga‐Mazón Abraham , Mata Rachel 
Published: December 2023

AbstractCompound 3, a trimeric anthranilic acid peptide, and another three metabolites were isolated from an organic extract from the culture medium of Malbranchea flocciformis ATCC 34530. The chemical structure proposed previously for 3 was unequivocally assigned via synthesis and X‐ray diffraction analysis. Tripeptide 3 showed insulinotropic properties by decreasing the postprandial peak in healthy and hyperglycemic mice. It also increased glucose‐induced insulin secretion in INS‐1E at 5 μM, specifically at higher glucose concentrations. These results revealed that 3 might act as an insulin sensitizer and a non‐classical insulin secretagogue. Altogether, these findings are in harmony with the in vivo oral glucose tolerance test and acute oral hypoglycemic assay. Finally, the chemical composition of the extract was established by the Global Natural Products Social Molecular Network platform. Phylogenetic analysis using the internal transcribed spacer region revealed that M. flocciformis ATCC 34530 is related to the Malbrancheaceae.
The Guidelines for the Design and Synthesis of Transition Metal Atom Doped Carbon Dots
Authors: Gao Fucheng , Liu Jiamei , Tang Qunwei , Jiang Yanyan 
Published: December 2023

AbstractAtoms doping is a practical approach to modulate the physicochemical properties of carbon dots (CDs) and thus has garnered increasing attention in recent years. Compared to non‐metal atoms, transition metal atoms (TMAs) possess more unoccupied orbitals and larger atomic radii. TMAs doping can significantly alter the electronic structure of CDs and bestow them with new intrinsic characteristics. TMAs‐doped CDs have exhibited widespread application potential as a new class of single‐atom‐based nanomaterials. However, challenges remain for the successful preparation and precise design of TMAs‐doped CDs. The key to successfully preparing TMA‐doped CDs lies in anchoring TMAs to the carbon precursors before the reaction. Herein, taking the formation mechanism of TMAs‐doped CDs as a starting point, we systematically summarized the ligands employed for synthesizing TMAs‐doped CDs and proposed the synthetic strategy involving multiple ligands. Additionally, we summarize the functional properties imparted to CDs by different TMA dopants to guide the design of TMA‐doped CDs with different functional characteristics. Finally, we describe the bottlenecks TMAs‐doped CDs face and provide an outlook on their future development.
Successful management of severe generalized tetanus in a 23‐year man with phenobarbital adjuvant: A case report
Authors: Ahmadi Arezoo , Karimpour‐Razkenari Elahe , Ansari Ramin , Marashi Mahforouzalsadat , Sharifnia Hamidreza , Najafi Atabak , Mojtahedzadeh Mojtaba 
Published: December 2023

Key Clinical MessageGeneralized tetanus is still a global concern with a mortality rate of up to 50%, especially in low and middle‐income countries. We reported a 23‐year‐old man from Afghanistan admitted to emergency department, with the chief complaint of generalized severe spasms and lockjaw. The patient had skin lesions and had never been vaccinated against tetanus. He intubated and admitted to the intensive care unit (ICU) with diagnose of severe generalized tetanus. After receiving tetanus immunoglobulin and intravenous metronidazole, a combination therapy of midazolam, propofol, atracurium, and morphine was administered. Due to the refractory muscular spasms intravenous phenobarbital started and little by little recovery was achieved. The patient receiving the first two doses of the Td vaccine, and discharged on Day 42 of hospitalization with no symptom recurrence. This case management showed adding phenobarbital to severe tetanus treatment regimen could significantly reduce refractory spasm caused by tetanus, also decrease other medication requirement.
Paget–Schroetter syndrome occurring in the nondominant hand
Authors: Fukushima Akina , Kobayashi Takaaki , Kuno Hayato , Hiroki Jiro , Yoshida Akihito 
Published: December 2023

Key Clinical MessagePaget‐Schroetter syndrome is the primary thrombotic event associated with venous thoracic outlet syndrome. It needs to be suspected when encountering localized brachial swelling and a dilated vein in patients with a history of upper limb exercise.
A rare presentation of gastro‐pleural fistula after Roux‐en‐Y gastric bypass, simultaneous fistula of gastric pouch, and remnant to the pleural space
Authors: Movahhed Ghasem Khalilian , Dalili Amin , Zandbaf Tooraj , Rezapanah Alireza , Jangjoo Ali , Seyfari Benyamin 
Published: December 2023

Key Clinical MessageAlthough gastro‐pleural fistulas after bariatric surgeries are rare, they are life‐threatening complications that should be suspected in patients who present with gastrointestinal or respiratory symptoms after bariatric surgery.AbstractPrevious studies showed an incidence rate of 0.2%–0.37% for gastro‐pleural fistulas after bariatric surgery. We report a 56‐year‐old female with a rare presentation of gastro‐pleural fistula after Roux‐en‐Y gastric bypass, simultaneous fistula of the gastric pouch, and remnant to the pleural space.
Probing the Reactive Intermediates in CO2 Hydrogenation on Ni/Al2O3 Catalysts with Modulation Excitation Spectroscopy
Authors: Kock Mikkel , Kowalewski Emil , Iltsiou Dimitra , Mielby Jerrik , Kegnæs Søren 
Published: December 2023

AbstractIn‐situ infrared spectroscopy is one of the most effective methods to study the surface species on solid catalysts. Still, it is sometimes difficult to identify the reactive intermediates because spectator species, the catalyst support, and experimental noise also contribute to the total spectra. In this study, we prepared three archetypical Ni/Al2O3 catalysts that showed significantly different catalytic activity and selectivity for CO2 hydrogenation, depending on the calcination and reduction temperature. After detailed characterization, we used a combination of Modulation Excitation‐Phase Sensitive Detection‐Diffuse Reflectance Infrared Fourier Transform Spectroscopy (ME‐PSD‐DRIFTS) and Steady State Isotopic Kinetic Analysis (SSITKA) to show that bicarbonates and formates are key reactive intermediates. Furthermore, we also observe carbonyls on the catalyst with the most metallic character and highest selectivity towards CH4. These results confirm that the hydrogenation of CO2 occurs in an associative and consecutive reaction pathway that is highly structure‐sensitive. In this way, we also demonstrate how the simultaneous collection of spectroscopic and kinetic data during modulated or transient experiments is a powerful tool for investigating solid catalysts under realistic operation conditions.
Constructing Lanthanide‐Organic Complexes for X‐ray Scintillation and Imaging
Authors: Lu Huangjie , Xu Miaomiao , Ma Jingqi , Yang Junpu , Bai Yaoyao , Zhang Zhi‐Hui , Qian Junfeng , He Ming‐Yang , Wang Jian‐Qiang , Lin Jian 
Published: December 2023

AbstractThe photoluminescent properties of lanthanide complexes have been thoroughly investigated; however, there have been much fewer studies showcasing their potential use in ionizing radiation detection. In this work, we delve into the photo‐ and radio‐induced luminescence of a series of lanthanide‐bearing organic‐inorganic hybrids and their potential as a platform for X‐ray scintillation and imaging. The judicious synergy between lanthanide cations and 2,6‐di(1H‐pyrazol‐1‐yl)isonicotinate (bppCOO−) ligands affords six new materials with three distinct structures. Notably, Eu‐bppCOO‐1 and Tb‐bppCOO‐2 display sharp fingerprint X‐ray‐excited luminescence (XEL), the intensities of which can be linearly correlated with the X‐ray dose rates over a broad dynamic range (0.007–4.55 mGy s−1). Moreover, the X‐ray sensing efficacies of Eu‐bppCOO‐1 and Tb‐bppCOO‐2 were evaluated, showing that Tb‐bppCOO‐2 features a lower detection limit of 4.06 μGy s−1 compared to 14.55 μGy s−1 of Eu‐bppCOO‐1. Given the higher X‐ray sensitivity and excellent radiation stability of Tb‐bppCOO‐2, we fabricated a flexible scintillator film for X‐ray imaging by embedding finely ground Tb‐bppCOO‐2 in the polydimethylsiloxane (PDMS) polymer. The resulting scintillator film can be utilized for high‐resolution X‐ray imaging with a spatial resolution of approximately 7 lp mm−1.
How customers' perceptions of innovation activities drive brand preference, purchase and recommendation: The moderating role of product category
Authors: Pham Thi Minh Ly , Tran Cong Duc , Trinh Thi Ha Huyen , Le Pham Tra Mi 
Published: December 2023

AbstractThis study investigated how innovation activities impact brand performance outcomes from the perspective of customer cognitive and affective mindsets. The collective findings from both Partial Least Squares Structural Equation Modeling (PLS‐SEM) and fuzzy set qualitative comparative analysis (fsQCA), based on 372 customer responses, demonstrated that a combination of product, process, store, and marketing innovation activities produces optimal results in terms of customer‐based brand equity, subsequently influencing purchase and recommendation. Post‐hoc analysis revealed that perceived innovation activities exert a weaker influence on brand equity in high‐tech product categories (e.g., smartphones) compared to lower‐tech product categories (e.g., skin care products and apparel). This study confirmed that customers' perceptions of brand innovation activities result from both technological innovation (e.g., cutting‐edge offerings) and symbolic innovations (e.g., new marketing communications).
Tau here, tau there, tau almost everywhere: Clarifying the distribution of tau in the adult CNS
Authors: Kanaan Nicholas M. 
Published: December 2023

AbstractThe microtubule‐associated protein tau has gained significant attention over the last several decades primarily due to its apparent role in the pathogenesis of several diseases, most notably Alzheimer's disease. While the field has focused largely on tau's potential contributions to disease mechanisms, comparably less work has focused on normal tau physiology. Moreover, as the field has grown, some misconceptions and dogmas regarding normal tau physiology have become engrained in the traditional narrative. Here, one of the most common misconceptions regarding tau, namely its normal cellular/subcellular distribution in the CNS, is discussed. The literature describing the presence of tau in neuronal somata, dendrites, axons and synapses, as well as in glial cells is described. The origins for the erroneous description of tau as an “axon‐specific,” “axon‐enriched” and/or “neuron‐specific” protein are discussed as well. The goal of this work is to help address these specific dogmatic misconceptions and provide a concise description of tau's normal cellular/subcellular localization in the adult CNS. This information can help refine our collective understanding of‐ and hypotheses about tau biology and pathobiology.
Sustainable production of triazoles from lignin major motifs
Authors: Zhu Wenqing , Shi Yue , Lu Jinfei , Han Fengan , Luo Wenhao , Xu Dezhu , Guo Tenglong , Huang Genping , Kühn Fritz E. , Zhang Bo , Zhang Tao 
Published: December 2023

AbstractAn efficiently catalyzed synthesis of pharmaceutically relevant 1,2,3‐trazoles from renewable resources is highly desirable. However, due to incompatible catalysis conditions, this endeavor remained challenging so far. Herein, a practical access protocol to 1,2,3‐triazoles, starting from lignin phenolic β‐O‐4 with γ‐OH group utilizing a vanadium‐based catalyst is presented. A broad substrate scope reaching up to 97 % yield of 1,2,3‐triazoles are obtained. The reaction pathway includes selective cleavage of double C−O bonds, cycloaddition, and dehydrogenation. Mechanistic studies and density‐functional theory (DFT) calculations suggest that the V‐based complex acts as a bifunctional catalyst for both selective C−O bonds cleavage and dehydrogenation. This synthetic pathway has been applied for the synthesis of pharmacological and biological active carbohydrate derivatives starting from biomass components as feedstock, enabling a potential sustainable route to triazolyl carbohydrate derivatives, which paves the way for lignin‐based heterocyclic aromatics in the pharmaceutical applications.
Beyond Small Molecular Cations: Elucidating the Alkaline Stability of Cationic Moieties at the Membrane Scale
Authors: Ling Qianjun , Wang Chenxi , Wang Tao , Yang Shanzhong , Li Xueliang , Wei Haibing , Ding Yunsheng 
Published: December 2023

AbstractA major hindrance in the commercialization of alkaline polyelectrolyte‐based electrochemical energy conversion devices is the development of durable anion exchange membranes (AEMs). Despite many alkali‐stable cations that have been explored, the stability of these cationic moieties at the membrane scale is in the blind. Herein, we present a molecularly designed polyaromatic AEM with cationic moieties in an alternating manner to unbiasedly compare the alkaline stability of piperidinium and ammonium groups at the membrane state. Using nuclear magnetic resonance spectroscopy, we demonstrate that the pentyltrimethyl group is about 2‐fold more stable than piperidinium within a polyaromatic scaffold, either in ex‐situ alkaline soaking or in‐situ cell operation. This finding challenges the judgment extrapolated from the stability trend of cations, that is, the piperidinium‐functionalized AEM is more alkali‐stable than the counterparts based on quaternary ammoniums. Moreover, the deterioration mechanism of piperidinium moiety after being embedded in polyaromatic backbone is rationalized by density functional theory.
Generation of a Dcx‐CreERT2 knock‐in mouse for genetic manipulation of newborn neurons
Authors: Perez Gabriella A. , Park Kyung‐Won , Lanza Denise , Cicardo Jenna , Uddin M. Danish , Jankowsky Joanna L. 
Published: December 2023

SummaryA wide variety of CreERT2 driver lines are available for genetic manipulation of adult‐born neurons in the mouse brain. These tools have been instrumental in studying fate potential, migration, circuit integration, and morphology of the stem cells supporting lifelong neurogenesis. Despite a wealth of tools, genetic manipulation of adult‐born neurons for circuit and behavioral studies has been limited by poor specificity of many driver lines targeting early progenitor cells and by the inaccessibility of lines selective for later stages of neuronal maturation. We sought to address these limitations by creating a new CreERT2 driver line targeted to the endogenous mouse doublecortin locus as a marker of fate‐specified neuroblasts and immature neurons. Our new model places a T2A‐CreERT2 cassette immediately downstream of the Dcx coding sequence on the X chromosome, allowing expression of both Dcx and CreERT2 proteins in the endogenous spatiotemporal pattern for this gene. We demonstrate that the new mouse line drives expression of a Cre‐dependent reporter throughout the brain in neonatal mice and in known neurogenic niches of adult animals. The line has been deposited with the Jackson Laboratory and should provide an accessible tool for studies targeting fate‐restricted neuronal precursors.
Copper‐Catalyzed Directed Diamination of Terminal Olefins with Diaziridinone
Authors: Li Junhua , Yang Yan , Shi Yian 
Published: December 2023

AbstractThis work describes a copper‐catalyzed 8‐aminoquinoline‐assisted diamination of terminal olefins with di‐t‐butyldiaziridinone as nitrogen source, providing a variety of 2‐(2‐oxoimidazolidin‐4‐yl)‐N‐(quinolin‐8‐yl)acetamides in moderate to good yields.