bluuebunny/crossref_metadata_2025_split huggingface dataset:
Forage senescence and disease influence elk pregnancy across the Greater Yellowstone Ecosystem
Authors: Bidder Owen R. , Connor Thomas , Morales Juan M. , Rickbeil Gregory J. M. , Merkle Jerod A. , Fuda Rebecca K. , Rogerson Jared D. , Scurlock Brandon M. , Edwards William H. , Cole Eric K. , McWhirter Douglas E. , Courtemanch Alyson B. , Dewey Sarah , Kauffman Matthew J. , MacNulty Daniel R. , du Toit Johan T. , Stahler Daniel R. , Middleton Arthur D. 
Published: December 2023

AbstractFor various temperate ungulate species, recent research has highlighted the potential for spring vegetation phenology (“green‐up”) to influence individual condition, with purported benefits to population productivity. However, few studies have been able to measure the benefit on vital rates directly, and fewer still have investigated the comparative influence of other phenological periods on ungulate vital rates. In this study, we tracked phenological changes throughout the duration of the growing season and examined how their timing affected the probability of pregnancy in an ungulate population. We did this for elk (Cervus canadensis) across the Greater Yellowstone Ecosystem (GYE) by sampling 1106 adult females in winter at 25 sites over a 13‐year period and assessing sources of variation in pregnancy using a Bayesian hierarchical model. Pregnancy rates were generally high across the GYE (82.4%), and the primary influences on probability of pregnancy were the timing of vegetation senescence (“brown‐down”) in autumn and exposure to the reproductive disease brucellosis. Earlier forage brown‐down in fall negatively influenced the probability of pregnancy of elk aged 6–9 years by an estimated 17.2% within the range (ca. 32 days) of observed brown‐down end dates. While summer habitat quality has been inferred to influence elk pregnancy previously, our findings specify the key influence of foraging conditions later in the seasonal cycle, immediately before the breeding season. The reproductive disease brucellosis was also an important factor, reducing the probability of pregnancy by 12.4% in elk in the 6‐ to 9‐year age class. Because pregnancy was tested before most disease‐induced abortions occur, the apparent mechanism for this effect is a prolonged reduction in fertility beyond the period of initial exposure in which fetal mortality is typically expected. Our results prompt greater scrutiny of the combined effects of late‐season phenology and disease on reproductive rates and population productivity in temperate ungulates.
Mutational landscape of head and neck cancer and cervical cancer in Chinese and Western population
Authors: Li Qunxing , Zhu Genhai , Zhang Lizao , Zeng Binghui , Cai Tingting , Wu Jiaying , Wei Bin , Xie Zhijun , He Lile , Tang Wenbing , Lin Xinyu , Lu Huaiwu , Wu Fan , Huang Jintao , Hu Huijun , Liu Niu , Fan Song 
Published: December 2023

AbstractBackgroundWe aimed to unbiasedly map the genetic mutation profile of HNSC and CESC associated with HPV status in the Chinese population (SYSU‐cohort) and compare them with Western population (TCGA‐cohort).MethodsFifty‐one HNSC patients (SYSU‐HNSC) and 38 CESC patients (SYSU‐CESC) were enrolled in this study. Genomic alterations were examined, and the profile was produced using the YuanSuTM450 gene panel (OrigiMed, Shanghai, China). The altered genes were inferred and compared to Western patients from TCGA cohorts.ResultsCompared to the TCGA‐HNSC cohort, FGFR3 mutation was identified as a novel target in SYSU‐HNSC with therapeutic potential. Compared to the TCGA‐CESC cohort, some epigenetic regulation‐associated genes were frequently mutated in SYSU‐CESC cohort (KMT2C, KMT2D, KDM5C, KMT2A).ConclusionIn summary, our study provides unbiased insights into the genetic landscape of HNSC and CESC in the Chinese population and highlights potential novel therapeutic targets that may benefit Chinese patients.
A quantile regression approach to identify risk factors for high blood glucose levels among Bangladeshi individuals
Authors: Aktar Mst. Farjana , Chowdhury Mashfiqul Huq , Rahman Md. Siddikur 
Published: December 2023

AbstractBackground and AimsDiabetes mellitus, characterized by high blood glucose, is an overwhelming public health concern globally, including in Bangladesh. The implication of this trend may pose a significant challenge to the health systems due to the lack of awareness and improper management of this chronic disease. To formulate strategies for public health planning, this study aims to explore the potential risk factors for elevated blood glucose levels among Bangladeshi individuals using advanced statistical methods and a nationally representative data set.MethodsThis study utilized data from the 2017−18 Bangladesh Demographic and Health Survey and included 11,863 individuals. A nonparametric Kruskal−Wallis test assessed the significant association between fasting plasma glucose levels and various risk factors. Additionally, a robust quantile regression model was applied to examine the net effects of each risk factor at different quantiles of the distribution.ResultsThe prevalence of diabetes is 8.1% among individuals in the study population, with variations observed across different administrative divisions in the country. Respondents from the Dhaka division respondents had a higher likelihood (24.1%) of having elevated plasma glucose and the Rangpur division had a lower risk (10.3%) of developing diabetes disease. This study identified several potential risk factors associated with elevated blood glucose levels, including hypertensive disease, overweight and obese body mass index, higher economic status, reduced physical activities, and older age, significantly contributing to develop diabetes mellitus.ConclusionThis study recommends promoting healthy lifestyles, increased physical activity, effective hypertension management, obesity reduction, and nationwide screening programs to control diabetes and noncommunicable diseases in Bangladesh. These preventive measures are crucial for reducing the existing prevalence of diabetes and working toward achieving the Sustainable Development Goals by 2030.
Usefulness of fluorescent ureteral catheter during laparoscopic residual ureterectomy
Authors: Honda Tomoko , Matsuoka Yuki , Osaki Yu , Tohi Yoichiro , Naito Hirohito , Kato Takuma , Okazoe Homare , Taoka Rikiya , Ueda Nobufumi , Sugimoto Mikio 
Published: December 2023

IntroductionThere have been reports of surgery for residual ureteral tumors, most of them involved open surgeries. Herein, we report a case of retroperitoneal scopic left ureteral resection and partial cystectomy, performed by placing a fluorescent ureteral catheter in the residual ureter.Case presentationA 79‐year‐old man was admitted to our hospital with a chief complaint of gross hematuria. He had undergone transperitoneal left radical nephrectomy due to angiomyolipoma 20 years ago. Computed tomography and Magnetic resonance imaging revealed a solid tumor in the left residual ureter. Retroperitoneal scopic residual ureterectomy has been performed. During the operation, a fluorescent ureteral catheter proved to be very helpful in detecting the ureter.ConclusionA fluorescent ureteral catheter is considered to be a useful tool in laparoscopic surgery, especially in cases where identification of the ureter is expected to be difficult, such as the residual ureter in this case.
Homework as a driver of change in psychotherapy
Authors: Ryum Truls , Bennion Mia , Kazantzis Nikolaos 
Published: December 2023

AbstractBackground and ObjectivesThe utilization of Between‐Session Homework (BSH) holds a longstanding tradition in the field of psychotherapy. Significantly, it serves as a pivotal catalyst for change within behavioral and cognitive‐behavioral therapies, and has also garnered endorsement within psychodynamic and humanistic‐experiential therapies. While our current conceptualization of BSH is characterized by assimilation and integration, diversity prevails in how BSH is incorporated into the treatment plan, spanning various therapy stages, thus necessitating a customized therapist‐client interpersonal dynamic. Far from being a panacea, the employment of BSH emerges as a highly sophisticated and intricate clinical methodology, demanding a high degree of therapist proficiency and competence to facilitate client engagement.MethodsIn this introductory paper, we present an issue of the Journal of Clinical Psychology: In Session that exemplifies the diverse modalities through which BSH can be integrated into clinical practice across various client demographics and within distinct psychotherapeutic paradigms. We place specific emphasis on the pivotal role of BSH and its interplay with proposed mechanisms of change throughout the course of treatment.ResultsInitially, we provide an overarching view of the subject and expound on empirical research substantiating the efficacy of BSH in psychotherapy. Subsequently, we delve into strategies for adeptly integrating and monitoring BSH within clinical practice.ConclusionsOur primary objectives encompass affording readers a more lucid comprehension of (1) the content and nature of homework; (2) the influence of BSH on treatment outcomes; and (3) the ways through which therapists can foster client engagement with BSH. Finally, we introduce the six papers comprising this issue.
PRG4 deficiency in mice alters skeletal structure, mechanics, and calvarial osteoclastogenesis, and rhPRG4 inhibits in vitro osteoclastogenesis
Authors: Tanguay Adam P. , Menon Nikhil G. , Boudreau Margaret H. , Jastrzebski Sandra , Woods Paige S. , Doyle Erica A. , Edwards W. Brent , Jay Gregory D. , Deymier Alix C. , Lorenzo Joseph , Lee Sun‐Kyeong , Schmidt Tannin A. 
Published: December 2023

AbstractOsteoporosis is a chronic disease characterized by reduced bone mass and increased fracture risk, estimated to affect over 10 million people in the United States alone. Drugs used to treat bone loss often come with significant limitations and/or long‐term safety concerns. Proteoglycan‐4 (PRG4, also known as lubricin) is a mucin‐like glycoprotein best known for its boundary lubricating function of articular cartilage. In more recent years, it has been shown that PRG4 has anti‐inflammatory properties, contributes to the maintenance of subchondral bone integrity, and patients with PRG4 mutations are osteopenic. However, it remains unknown how PRG4 impacts mechanical and material properties of bone. Therefore, our objective was to perform a phenotyping study of bone in a Prg4 gene trap (GT) mouse (PRG4 deficient). We found that femurs of Prg4 GT mice have altered mechanical, structural, and material properties relative to wildtype littermates. Additionally, Prg4 GT mice have a greater number of calvarial osteoclasts than wildtype mice, but do not have a notable inflammatory serum profile. Finally, Prg4 GT mice do not have an altered rate of bone formation, and exogenous recombinant human PRG4 (rhPRG4) administration inhibited osteoclastogenesis in vitro, suggesting that the skeletal phenotype may be due to changes in bone resorption. Overall, this work demonstrates that PRG4 deficiency affects several integral properties of bone structure, mechanics, and skeletal cell activity, and provides the foundation and insight toward future work evaluating PRG4 as a potential therapeutic target in treating bone loss.
Acorn and aquatic invertebrate biomass in Mississippi Alluvial Valley hardwood bottomlands
Authors: Straub Jacob N. , Kaminski Richard M. , Leach Alan. G. , Ezell Andrew W. , Leininger Theodor , Foth Justyn , Davis J. Brian 
Published: December 2023

AbstractThe Mississippi Alluvial Valley (MAV) is an internationally important migration and wintering region for Nearctic waterfowl. Most of the MAV is a lowland forested floodplain that contains vast stands of red oaks (Quercus spp.). These trees produce acorns and, when forests flood, diverse communities of aquatic invertebrates emerge, providing diverse nutritious foods for wintering ducks. The MAV is within the Lower Mississippi Valley Joint Venture (LMV JV) region of the North American Waterfowl Management Plan, but no combined MAV‐wide estimates of acorn and invertebrate biomass exist to determine foraging carrying capacity for conservation planning or actions by the LMV JV or other partners in regions containing southern red oaks. We sampled acorns that fell to the ground or were submersed under shallow water deemed accessible to foraging ducks and aquatic invertebrates in the MAV of Louisiana, Mississippi, Missouri, and Tennessee, USA, during fall‐winter 2009–2011. In good and poor masting years, acorn abundance was non‐linearly related to the percentage of the forest canopy made up of red oaks and peaked in late autumn or winter when most other waterfowl resources are depleted or decomposed. This finding is novel and represents a deviation from how the LMV JV has traditionally assumed food resources exist for waterfowl in hardwood bottomlands. We used a daily ration model to estimate energy use days (EUDs) from combined acorn and invertebrate biomasses relative to red oak canopy coverage. For good and poor acorn masting years at the mean MAV‐wide red oak canopy coverage of 45%, EUD = 2,273.1 days/ha and 161.2 days/ha, respectively. The LMV JV currently uses EUD = 385–502 days/ha for forests with 40–50% red oak canopy coverage. Because acorns and aquatic macro‐invertebrates are a food resource that persists through winter and reaches peak abundance later in winter, we contend conservation planners have undervalued the potential of bottomland hardwoods to provide energy for wintering ducks.
Identification of RP11‐770J1.4 as immune‐related lncRNA regulating the CTXN1–cGAS–STING axis in histologically lower‐grade glioma
Authors: Zhuang Qiyuan , Liu Chaxian , Hu Yihan , Liu Ying , Lyu Yingying , Liao Yuheng , Chen Liang , Yang Hui , Mao Ying 
Published: December 2023

AbstractHuman gliomas are lethal brain cancers. Emerging evidence revealed the regulatory role of long noncoding RNAs (lncRNAs) in tumors. Here, we performed a comprehensive analysis of the expression profiles of RNAs in histologically lower‐grade glioma (LGG). Enrichment analysis revealed that glioma is influenced by immune‐related signatures. Survival analysis further established the close correlation between network features and glioma prognosis. Subsequent experiments showed lncRNA RP11‐770J1.4 regulates CTXN1 expression through hsa‐miR‐124‐3p. Correlation analysis identified lncRNA RP11‐770J1.4 was immune related, specifically involved in the cytosolic DNA sensing pathway. Downregulated lncRNA RP11‐770J1.4 resulted in increased spontaneous gene expression of the cGAS–STING pathway. Single‐cell RNA sequencing analysis, along with investigations in a glioblastoma stem cell model and patient sample analysis, demonstrated the predominant localization of CTXN1 within tumor cores rather than peripheral regions. Immunohistochemistry staining established a negative correlation between CTXN1 expression and infiltration of CD8+ T cells. In vivo, Ctxn1 knockdown in GL261 cells led to decreased tumor burden and improved survival while increasing infiltration of CD8+ T cells. These findings unveil novel insights into the lncRNA RP11‐770J1.4–CTXN1 as a potential immune regulatory axis, highlighting its therapeutic implications for histologically LGGs.
Singing silver‐haired bats (Lasionycteris noctivagans)
Authors: Lausen Cori L. , Falxa Greg A. , Solick Donald I. , McEwan Alexandria L. , Baker Michael D. , de Freitas Emily , Sarell Mike 
Published: December 2023

AbstractCharacterizing sounds produced by animals can lead to better understanding of their behavioral ecology and conservation. While considerable focus has been on signals used by bats for echolocation, there has been less emphasis on nonecholocation sounds. We describe songs (i.e., acoustic vocalizations with distinctive syllable types in series or in complex motifs) produced by silver‐haired bat (Lasionycteris noctivagans). Songs, characterized by a sequence (song phrase) of 3 distinct vocalization types, were confirmed by observing free‐flying, silver‐haired bats at mine hibernacula in British Columbia, Canada. The song patterns were relatively consistent with each song phrase consisting of a lead call, followed by a droplet call, and finishing with a series of multiple chirp calls. The function of the songs is unknown, however, as other bat species produce songs for mating, we propose silver‐haired bat songs may similarly be associated with courtship or mating. Alternative functions cannot be ruled out, particularly because we recorded some songs outside of the accepted mating period. Other research has determined peak mating of silver‐haired bats occurs in fall, and spring mating has been documented. Here we additionally provide evidence of winter mating in British Columbia. The proportion of silver‐haired bat songs recorded relative to echolocation recordings varied across locations and seasons. While we recorded songs in all months of the year, more than half of the songs were produced during winter, and 93.4% (of 1,857) were produced outside of summer months. Song production in summer could be associated with other behaviors such as learning or practice, establishing or maintaining social bonds, or male‐male competition. To provide landscape and temporal context, we summarize acoustic datasets from numerous locations in western North America where recordings were made between 2005 and 2022.
Adding Preferences and Moral Values in an Agent-Based Simulation Framework for High-Performance Computing
Authors: Marin Gutierrez David , Vázquez-Salceda Javier , Alvarez-Napagao Sergio , Gnatyshak Dmitry 
Published: December 2023

AbstractAgent-Based Simulation is a suitable approach used now-a-days to simulate and analyze complex societal environments and scenarios. Current Agent-Based Simulation frameworks either scale quite well in computation but implement very simple reasoning mechanisms, or employ complex reasoning systems at the expense of scalability. In this paper we present our work to extend an agent-based HPC platform, enabling goal-driven agents with HTN planning capabilities to scale and run parallelly. Our extension includes preferences over their objectives, preferences over their plans, actions, and moral values. We show the expresiveness of the extended platform with a sample scenario.
Pelvic flexion/extension and its impact on functional acetabular alignment and stability following total hip replacement
Authors: Hafez Mahmoud A , Jaramaz Branislav , DiGioia Anthony M 
Published: December 2023

Abstract
Purpose
Dislocation following total hip arthroplasty (THA) remains a significant clinical problem and can occur even with optimal implant alignment. We hypothesized that different patterns of pelvic flexion/extension (PFE) during daily activities may influence acetabular alignment and contribute to impingement and instability following THA. Recently, there has been an increased interest in spinopelvic alignment and its impact on THA. Therefore, this study aimed to identify different patterns of PFE that could be predictive of instability following THA.

Methods
A range of motion (ROM) simulator was used to demonstrate the effects of different patterns of PFE on ROM and impingement. The findings were applied to PFE measurements obtained from 84 patients in standing and sitting positions.

Results
Three different categories of PFE were identified: normal, hypermobile, and stiff. ROM simulator revealed that changes in PFE had affected ROM and impingement significantly. Patients in the stiff pelvis category, even with “optimal” implant alignment, were more susceptible to implant impingement.

Conclusions
The different patterns of PFE during daily activities could affect acetabular alignment and stability following THA. We propose a classification system that can identify different types of PFE and predict their effects on the stability of prostheses following THA. Hence, we believe that patients with unfavorable PFE may require modified cup alignment.
Skull fractures by glass bottles tested on cadaveric heads
Authors: Lorente Ana I. , Maza-Peón Samuel , Hidalgo-García César , López-de-Celis Carlos , Rodríguez-Sanz Jacobo , Pérez-Bellmunt Albert , Maza-Frechín Mario 
Published: December 2023

AbstractHead trauma is frequently related to the misuse of drinking vessels as weapons. Forensic reports usually evaluate these blunt injuries as having occurred in scenarios where the alcohol intake is high. Fatal consequences are seen in blows with glass bottles aiming at the head. To prove the outcome that a glass bottle thrown to the head could cause, three intact human cadaver heads were impacted with 1-liter glass bottles at 9.5 m/s using a drop-tower. The impact location covered the left temporal bone, sphenoid bone, and zygomatic arch. The contact between the head and the bottle was produced at an angle of 90° with (1) the valve of the bottle, (2) the bottom of the bottle, and (3) with the head rotated 20° in the frontal plane touching again with the bottom of the bottle. The three bottles remained intact after the impact, and the injury outcomes were determined by computed tomography (CT). The alterations were highly dependent on the impact orientation. The outcome varied from no injury to severe bone fractures. In the most injurious case (#3), fractures were identified in the cranial base, sphenoid bone, and zygomatic bone. These testing conditions were selected to replicate one specific legal case, as required by the plaintiff. Physical disputes with bar glassware can lead to complex combinations of blunt and sharp-force injuries. Controlled biomechanical studies can benefit forensic analyses of violence involving glassware by providing a better understanding of the underlying injury mechanisms.
Viscosity, Interfacial Tension, and Density of 2-Propanol and Acetone up to 423 K by Surface Light Scattering and Conventional Methods
Authors: Kerscher Manuel , Braun Lena M. , Jander Julius H. , Rausch Michael H. , Koller Thomas M. , Wasserscheid Peter , Fröba Andreas P. 
Published: December 2023

AbstractDespite the extensive use of 2-propanol and acetone in a wide range of applications in the chemical industry and in energy engineering, there is a lack of experimental data in the literature for their thermophysical properties including viscosity, interfacial tension, and density, especially at elevated temperatures beyond the respective normal boiling points. In the present study, the liquid viscosity and interfacial tension were determined simultaneously by surface light scattering (SLS) with average expanded uncertainties of (1.7 and 0.9)% at or close to saturation conditions for temperatures between (273 and 403) K. Furthermore, capillary viscometry (CV) and vibrating-tube densimetry were employed to measure the liquid viscosity at ambient pressure of 0.1 MPa from (283 to 353) K and the liquid density close to saturation conditions between (278 and 423) K. The obtained density data were used for the evaluation of both SLS and CV experiments. In comparison with literature data, the present density data show agreement for 2-propanol over the entire temperature range. In contrast, deviations of up to 0.5% at the maximum temperature can be found for acetone. For the viscosity and interfacial tension at low temperatures, agreement of the measurement results among each other and with literature data is mostly found. At elevated temperatures, the increasing deviations of the present experimental viscosity and interfacial tension data from recommended correlations indicate a lack of reliable data needed for their development. Overall, this work contributes to an improvement of the database for viscosity, interfacial tension, and density of 2-propanol and acetone over a wide temperature range up to 423 K.