bluuebunny/crossref_metadata_2025_split huggingface dataset:
Ferroptosis in early brain injury after subarachnoid hemorrhage: review of literature
Authors: Kang Junlin , Tian Shilai , Zhang Lei , Yang Gang 
Published: February 2024

AbstractSpontaneous subarachnoid hemorrhage (SAH), mainly caused by ruptured intracranial aneurysms, is a serious acute cerebrovascular disease. Early brain injury (EBI) is all brain injury occurring within 72 h after SAH, mainly including increased intracranial pressure, decreased cerebral blood flow, disruption of the blood-brain barrier, brain edema, oxidative stress, and neuroinflammation. It activates cell death pathways, leading to neuronal and glial cell death, and is significantly associated with poor prognosis. Ferroptosis is characterized by iron-dependent accumulation of lipid peroxides and is involved in the process of neuron and glial cell death in early brain injury. This paper reviews the research progress of ferroptosis in early brain injury after subarachnoid hemorrhage and provides new ideas for future research.
Risk prediction models for lung cancer in people who have never smoked: a protocol of a systematic review
Authors: Issanov Alpamys , Aravindakshan Atul , Puil Lorri , Tammemägi Martin C. , Lam Stephen , Dummer Trevor J. B. 
Published: February 2024

AbstractBackgroundLung cancer is one of the most commonly diagnosed cancers and the leading cause of cancer-related death worldwide. Although smoking is the primary cause of the cancer, lung cancer is also commonly diagnosed in people who have never smoked. Currently, the proportion of people who have never smoked diagnosed with lung cancer is increasing. Despite this alarming trend, this population is ineligible for lung screening. With the increasing proportion of people who have never smoked among lung cancer cases, there is a pressing need to develop prediction models to identify high-risk people who have never smoked and include them in lung cancer screening programs. Thus, our systematic review is intended to provide a comprehensive summary of the evidence on existing risk prediction models for lung cancer in people who have never smoked.MethodsElectronic searches will be conducted in MEDLINE (Ovid), Embase (Ovid), Web of Science Core Collection (Clarivate Analytics), Scopus, and Europe PMC and Open-Access Theses and Dissertations databases. Two reviewers will independently perform title and abstract screening, full-text review, and data extraction using the Covidence review platform. Data extraction will be performed based on the Checklist for Critical Appraisal and Data Extraction for Systematic Reviews of Prediction Modeling Studies (CHARMS). The risk of bias will be evaluated independently by two reviewers using the Prediction model Risk-of-Bias Assessment Tool (PROBAST) tool. If a sufficient number of studies are identified to have externally validated the same prediction model, we will combine model performance measures to evaluate the model’s average predictive accuracy (e.g., calibration, discrimination) across diverse settings and populations and explore sources of heterogeneity.DiscussionThe results of the review will identify risk prediction models for lung cancer in people who have never smoked. These will be useful for researchers planning to develop novel prediction models, and for clinical practitioners and policy makers seeking guidance for clinical decision-making and the formulation of future lung cancer screening strategies for people who have never smoked.Systematic review registrationThis protocol has been registered in PROSPERO under the registration number CRD42023483824.
Monocyte lymphocyte ratio, IL 6, and their association with increased carotid intima-media thickness as simple predictive markers for nephropathy in Egyptian diabetic patients
Authors: Ibrahim Heba Mahmoud Mohamed , Bahgat Heba Morad , Sharshar Deena Ahmed , Ramzy Tarek Abdel Azim 
Published: February 2024

Abstract
Background
Inflammation is a cardinal mechanism of diabetic kidney disease (DKD). Interleukin-6 (IL6) is a reliable indicator that plays a role in the progression of DKD. Monocyte-to-lymphocyte ratio (MLR) is also implicated in this inflammatory process. The progression of DKD is associated with increased carotid intima-media thickness (CIMT), which is an independent predictor of atherosclerosis.

Aim
The role of IL6 and MLR ratio influencing the progression of DKD was assessed using the urinary albumin creatinine ratio (UACR) and glomerular filtration rate (GFR). Moreover, their contribution to increasing CIMT in DKD was assessed.

Methods
An observational prospective study was conducted on ninety diabetic patients presented to the Internal Medicine Clinic at Kasr AlAiny. The subjects were classified into three groups, thirty patients for each, according to UACR: with normoalbuminuria, microalbuminuria, and macroalbuminuria. A history and clinical assessment, CBC, MLR, HbA1c, lipid profile, IL6, creatinine, and eGFR were carried out. Furthermore, CIMT was measured using Doppler ultrasound.

Results
The results showed that IL6 and MLR were significantly higher in the macroalbuminuria group compared to the other two groups with p < 0.001, suggesting that their higher level could predict the progression of DKD. According to the ROC curve, the cutoff values of MLR and IL6 were 0.3425 and 7 pg/ml, respectively. Moreover, CIMT increased significantly in micro and macroalbuminuric patients with p > 0.001. IL6 and MLR were positively correlated with CIMT in micro and macroalbuminuric patients.

Conclusion
Both MLR and IL-6, as simple biomarkers associated with increased CIMT, play an important role in predicting the nephropathy of DKD patients.
Empowering scientific progress: the vital role of open-access, peer-reviewed methods and protocols
Authors: Cilibrasi Chiara 
Published: February 2024

AbstractIn the ever-evolving landscape of scientific research, the importance of detailed, accessible methods and step-by-step reusable protocols cannot be overstated. In alignment with this BMC Methods, is dedicated to facilitating the dissemination of open-access, peer-reviewed novel experimental procedures, techniques, and methodologies to promote reproducibility, transparency, and the advancement of scientific methods in the natural sciences.
Accelerated Early Childhood Growth Is Associated With the Development of Earlier Adrenarche and Puberty
Authors: Liimatta Jani , Jääskeläinen Jarmo , Mäntyselkä Aino , Häkkinen Merja R , Auriola Seppo , Voutilainen Raimo , Flück Christa E , Lakka Timo A 
Published: February 2024

Abstract

Context
Small birth size and increased postnatal growth have been associated with earlier timing of adrenarche and puberty, but it is not well known whether these factors alone or together lead to earlier maturation.

Objective
This work aimed to search for different growth trajectories using a clustering approach to analyze the effects of birth size and postnatal growth on adrenarchal and pubertal development.

Methods
Altogether 351 children (48% girls) were examined prospectively at ages 6 to 9 and 9 to 11 years. Birth and early-growth data were collected retrospectively. Main outcome measures included clinical signs of adrenarche and puberty, and serum androgen concentrations (dehydroepiandrosterone, dehydroepiandrosterone sulfate, androstenedione, testosterone).

Results
We detected 4 clusters with different birth sizes and postnatal growth trajectories: 1) children with average birth size and increased postnatal growth (AI), 2) children with small birth size and increased postnatal growth (SI), 3) children with average birth size and postnatal growth (AA), and 4) children with small birth size and average postnatal growth (SA). Thelarche at age 9 to 11 was most common and serum androgens at ages 6 to 9 and 9 to 11 years were highest in girls belonging to the AI and SI groups. Similar patterns in the onset of puberty and in androgen levels were not seen in the SA group.

Conclusion
Increased early growth and weight gain predict higher serum androgen concentrations and earlier onset of puberty in girls. Adrenarche and puberty do not appear to be shifted earlier in children with small birth size who do not have catch-up growth.
A mutation in F-actin polymerization factor suppresses the distal arthrogryposis type 5 PIEZO2 pathogenic variant in Caenorhabditis elegans
Authors: Bai Xiaofei , Smith Harold E. , Romero Luis O. , Bell Briar , Vásquez Valeria , Golden Andy 
Published: February 2024

ABSTRACT
The mechanosensitive PIEZO channel family has been linked to over 26 disorders and diseases. Although progress has been made in understanding these channels at the structural and functional levels, the underlying mechanisms of PIEZO-associated diseases remain elusive. In this study, we engineered four PIEZO-based disease models using CRISPR/Cas9 gene editing. We performed an unbiased chemical mutagen-based genetic suppressor screen to identify putative suppressors of a conserved gain-of-function variant pezo-1[R2405P] that in human PIEZO2 causes distal arthrogryposis type 5 (DA5; p. R2718P). Electrophysiological analyses indicate that pezo-1(R2405P) is a gain-of-function allele. Using genomic mapping and whole-genome sequencing approaches, we identified a candidate suppressor allele in the C. elegans gene gex-3. This gene is an ortholog of human NCKAP1 (NCK-associated protein 1), a subunit of the Wiskott-Aldrich syndrome protein (WASP)-verprolin homologous protein (WAVE/SCAR) complex, which regulates F-actin polymerization. Depletion of gex-3 by RNAi, or with the suppressor allele gex-3(av259[L353F]), significantly increased brood size and ovulation rate, as well as alleviating the crushed oocyte phenotype of the pezo-1(R2405P) mutant. Expression of GEX-3 in the soma is required to rescue the brood size defects in pezo-1(R2405P) animals. Actin organization and orientation were disrupted and distorted in the pezo-1 mutants. Mutation of gex-3(L353F) partially alleviated these defects. The identification of gex-3 as a suppressor of the pathogenic variant pezo-1(R2405P) suggests that the PIEZO coordinates with the cytoskeleton regulator to maintain the F-actin network and provides insight into the molecular mechanisms of DA5 and other PIEZO-associated diseases.
Diogenes syndrome - causes and treatment of pathological hoarding and self neglect
Authors: Czarnota-Kuczyńska Julia , Cichoń Katarzyna , Chyćko Małgorzata , Trąbka Natalia , Demidowicz Gabriela , Younes Martyna , Lasota Nina , Wiśniewski Wojciech , Lambach Maciej , Kowalczyk Klaudia 
Published: February 2024

Introduction
Diogenes syndrome is a behavioral disorder typically described in physically neglected people living in extreme poverty, unsanitary conditions and self-imposed isolation, who often refuse outside help and tend to accumulate unusual objects. This syndrome is gaining increasing attention in the world of neurology and psychiatry.

The aim of the study
To summarize current knowledge on the causes of Diogenes syndrome, its characteristics and treatment.

Material and methods
The search of the Pubmed and Google Scholar database was carried out using keywords, in order to find the latest publications.

Summary
Diogenes syndrome is a complex disease that will affect an increasing number of elderly people as the population ages. There is a lack of extensive research to create clear diagnostic criteria, classification and treatment for Diogenes syndrome. The creation of a disease entity would enable earlier diagnosis and help patients.
Assessment of the Relationship Between Genetic Determinants of Migraine and Thyroid Dysfunction - Review
Authors: Kwiecień Justyna , Getka Beata , Łata Michał , Przyborowska Kinga , Wiejak Katarzyna , Rukat Mateusz 
Published: February 2024

Introduction and objective: The purpose of this paper is a systematic review of articles and research in the context of the relationship between genetic determinants of migraine and thyroid dysfunction.
Materials and methods: A non-systematic review of the scientific literature was carried out according to the following keywords: PubMed was searched and 76 articles published up to 2023 were analyzed.
Description of the state of knowledge: Epidemiological studies confirm the co-occurrence of migraine and thyroid dysfunction, especially hypothyroidism, which are considered to be diseases with a strong genetic background. Thyroid function parameters such as TSH and fT4 are susceptible to genetic influences. However, there is a lack of consistent interpretation of the observational results, which highlights the need for further research. Analysis of gene overlaps and links between headache and thyroid function, based on GWAS data, could shed light on the complex genetic interactions underlying this association.
Summary: The genetic associations revealed in the study enhance our comprehension of the intricate relationship between migraine and thyroid dysfunction. These findings not only offer the prospect of developing biomarkers for identifying migraine patients who might benefit from thyroid hormone therapy but also underscore the promising potential of future genetic studies in providing biological insights to advance clinical decision-making in understanding and addressing these interconnected phenomena.
Radiological outcomes following surgical fixation with wires versus moulded cast for patients with a dorsally displaced fracture of the distal radius: a radiographic analysis from the DRAFFT2 trial
Authors: Plant Caroline E. , Ooms Alexander , Cook Jonathan A. , Costa Matthew L. 
Published: February 2024

AimsThe primary aim of this study was to report the radiological outcomes of patients with a dorsally displaced distal radius fracture who were randomized to a moulded cast or surgical fixation with wires following manipulation and closed reduction of their fracture. The secondary aim was to correlate radiological outcomes with patient-reported outcome measures (PROMs) in the year following injury.MethodsParticipants were recruited as part of DRAFFT2, a UK multicentre clinical trial. Participants were aged 16 years or over with a dorsally displaced distal radius fracture, and were eligible for the trial if they needed a manipulation of their fracture, as recommended by their treating surgeon. Participants were randomly allocated on a 1:1 ratio to moulded cast or Kirschner wires after manipulation of the fracture in the operating theatre. Standard posteroanterior and lateral radiographs were performed in the radiology department of participating centres at the time of the patient’s initial assessment in the emergency department and six weeks postoperatively. Intraoperative fluoroscopic images taken at the time of fracture reduction were also assessed.ResultsPatients treated with surgical fixation with wires had less dorsal angulation of the radius versus those treated in a moulded cast at six weeks after manipulation of the fracture; the mean difference of -4.13° was statistically significant (95% confidence interval 5.82 to -2.45). There was no evidence of a difference in radial shortening. However, there was no correlation between these radiological measurements and PROMs at any timepoint in the 12 months post-injury.ConclusionFor patients with a dorsally displaced distal radius fracture treated with a closed manipulation, surgical fixation with wires leads to less dorsal angulation on radiographs at six weeks compared with patients treated in a moulded plaster cast alone. However, the difference in dorsal angulation was small and did not correlate with patient-reported pain and function.Cite this article: Bone Jt Open 2024;5(2):132–138.
Geometric lightguide for near-eye light field displays
Authors: Chen Shan-Ling , Fu Li-Wei , Huang Jiun-Woei , Shih Kuang-Tsu , Chen Homer H. 
Published: February 2024

Most near-eye displays with one fixed focal plane suffer from the vergence–accommodation conflict and cause visual discomfort to users. In contrast, light field displays can provide natural and comfortable 3D visual sensation to users without the conflict. This paper presents a near-eye light field display consisting of a geometric lightguide and a light field generator, along with a collimator to ensure the light rays propagating in the lightguide are collimated. Unlike most lightguides, which reduce thickness by employing total internal reflection that can easily generate stray light, our lightguide directly propagates light rays without total internal reflection. The partially reflective mirrors of the lightguide expand the exit pupil to achieve an eyebox of 13mm(horizontal)×6.5mm(vertical) with an eye relief of 18 mm. The collimator and the light field generator, both having effective focal lengths different in the horizontal and vertical directions, are designed to provide a 40-deg diagonal field of view. The working range of the light field generator, which is 30 cm to infinity, is verified qualitatively and quantitatively by experiments. We optimize the illuminance uniformity and analyze the illuminance variation across the eyebox. Further, we minimize the ghost artifact (referring to the split-up of light fields replicated by the partially reflective mirrors) by orienting the partially reflective mirrors at slightly different angles to enhance the image quality for short-range applications such as medical surgery.
Effects of metformin on glucose metabolism and mitochondrial function in patients with obstructive sleep apnea: A pilot randomized trial
Authors: Zunica Elizabeth R. M. , Heintz Elizabeth C. , Dantas Wagner S. , Hebert R. Caitlin , Tanksley MaKayla , Beyl Robbie A. , Mader Edward C. , Kirwan John P. , Axelrod Christopher L. , Singh Prachi 
Published: February 2024

AbstractObstructive sleep apnea (OSA) is associated with increased risk for diabetes, and standard treatment with positive airway pressure (PAP) device shows inconsistent effects on glucose metabolism. Metformin is known to treat and prevent diabetes, but its effects on skeletal muscle mitochondrial function are not completely understood. Here, we evaluate the effects of metformin on glucose metabolism and skeletal muscle mitochondrial function in patients with OSA. Sixteen adults with obesity (50.9 ± 6.7 years, BMI: 36.5 ± 2.9 kg/m2) and moderate‐to‐severe OSA were provided with PAP treatment and randomized to 3 months of placebo (n = 8) or metformin (n = 8) treatment in a double‐blind parallel‐group design. Whole body glucose metabolism was determined by oral glucose tolerance test. A skeletal muscle biopsy was obtained to evaluate mitochondrial respiratory capacity and expression of proteins related to mitochondrial dynamics and energy metabolism. Whole body insulin‐sensitivity (Matsuda index) did not change in metformin or placebo treated groups. However, metformin treatment prevented increases in insulin release relative to placebo during follow‐up. Insulin area under the curve (AUC) and insulin to glucose AUC ratio increased in placebo but remained unchanged with metformin. Furthermore, metformin treatment improved skeletal muscle mitochondrial respiratory capacity and dynamics relative to placebo. Metformin treatment prevented the decline in whole body glucose homeostasis and skeletal muscle mitochondrial function in patients with moderate to severe OSA. Patients with OSA may benefit from the addition of metformin to prevent diabetes.
Anticorrosive action of eco-friendly plant extracts on mild steel in different concentrations of hydrochloric acid
Authors: Sharma Shobhana , Solanki Aashu Singh , Sharma Sushil Kumar 
Published: February 2024

Abstract
The extracts of different parts of plants (leaf, stem, and flower) act as a green, environmentally friendly, economical, and safe corrosion inhibitors. The eco-friendly extracts of plant material provide an excellent alternative that substitutes toxic traditional (organic and inorganic) corrosion inhibitors. The plant extracts are renewable and readily available; thus, they occupy a unique position in the family of green inhibitors. The plant extract contains several bioactive compounds, such as flavonoids, tannins, polyphenols, phenolic acids, glycosides, flavonols, etc., which possess experienced significant interest as anti-corrosive agents. These plant extracts contain several heteroatoms like phosphorus, nitrogen, sulfur, oxygen, etc., which are adsorbed on the metallic surface and form an inert protective layer that protects metal from a corrosive environment. Thus, this article aims to shed light on the efficiency of plant extract in protecting steel in an acidic environment.
Knowledge of smoking and influencing factors among school-going adolescents in Timor-Leste
Authors: Cheah Yong Kang 
Published: February 2024

Abstract

Objectives
Knowledge of smoking is a protective factor for adolescent smoking. This study is the first to examine sociodemographic and lifestyle factors associated with adolescents’ knowledge of smoking in Timor-Leste. It is also a pioneering investigation into the ways in which exposure to anti-tobacco messages and health warnings on cigarette packages, and involvement in smoking-related education at schools and home mediate the relationship between school grade levels and smoking knowledge.

Methods
Data were obtained from the Global Youth Tobacco Survey Timor-Leste. Ordered logistic regressions were used to examine the associations between knowledge of smoking and sociodemographic, and lifestyle factors. Structural equation modelling was utilized to explore the mediating effects.

Results
Adolescents were less likely to have high knowledge of smoking if they were lower-secondary students, were males, had unemployed parents and had no closest friends who smoked. The relationship between grade levels and smoking knowledge was partly mediated by awareness of anti-tobacco messages on mass media, school education about the dangers of smoking and family discussion about smoking.

Conclusions
Sociodemographic and lifestyle factors play an important role in determining knowledge of smoking among adolescents. To some extent, awareness-, education- and family-related variables explain how grade levels affect smoking knowledge.
Trend and Fuzzy Time Series Analysis of Live Births Registration in Northern Ghana
Authors: Nagumsi Abdulai , Nasiru Suleman , Kobilla Abdul-Aziz Adam , Mustapha Mohammed Hashim Bamba 
Published: February 2024

Abstract
This study investigated four trend analysis models namely; linear, quadratic, semi log linear and semi log quadratic to study the pattern of live births registration in the Northern Region of Ghana. The study revealed that Semi log linear trend model is the best trend model for studying the pattern of live births registration in the Northern Region of Ghana based on AIC and BIC criteria. The study further fitted four existing fuzzy time series (FTS) models for forecasting live births registration in the Northern Region of Ghana. The Chen, Singh, Heuristic and Chen-Hsu models are the four models used to analyze the data.
Deep Targeting: Zur Steigerung der Eingriffstiefe in die Erfahrungsspielräume des Sozialen
Authors: Ochs Carsten 
Published: February 2024

Zusammenfassung
Der Beitrag nimmt Facebooks Targeting-Praktiken im Kontext der Erstürmung des US-amerikanischen Kapitols 2021 zum Anlass einer soziologischen Targeting-Analyse. Er argumentiert zunächst dafür, den Analysemodus umzustellen vom in der Sozialphilosophie üblichen Fokus auf Entscheidungen auf die Kategorie der Erfahrung. Daraufhin erfolgt eine pragmatistische Konzeption des Erfahrungsbegriffs, an die sich eine Klärung der Kriterien zur Bestimmung der gesellschaftlichen „Eingriffstiefe“ des Targeting anschließt. Hierzu wird die erweiterte Heuristik Luhmannscher Sinndimensionen (sachlich, sozial, zeitlich, räumlich) fruchtbar gemacht. Die Analyse des Targeting in allen Sinndimensionen kulminiert in der These, dass zeitgenössisches Deep Targeting durch Orientierung am Aktualen und durch Steigerung der Eingriffstiefe in die Erfahrungsspielräume des Sozialen zu einer Kontingenz-einschränkenden Verengung von Erfahrung führt. Aus dieser These werden abschließend normative Konsequenzen gezogen.