bluuebunny/crossref_metadata_2025_split huggingface dataset:
Assessing the feasibility, safety, and nutritional quality of using wild-caught pest flies in animal feed
Authors: Van Nest Kortnee , Swistek Sabrina E , Olmstead Morgan L , De La Mota-Peynado Alina , Ewing Robert D , Brabec Daniel , Mitzel Dana , Oppert Brenda , Cohnstaedt Lee W , Shults Phillip 
Published: January 2024

Abstract
Studies have investigated the potential of using farmed insects in animal feeds; however, little research has been done using wild-caught insects for this purpose. Concerns about inadequate quantities collected, environmental impacts, and the spread of pathogens contribute to the preferred utilization of farmed insects. Nevertheless, by harvesting certain pest species from intensified agricultural operations, producers could provide their animals with affordable and sustainable protein sources while also reducing pest populations. This study explores the possibility of collecting large quantities of pest flies from livestock operations and analyzes the flies’ nutritional content, potential pathogen load, and various disinfection methods. Using a newly designed mass collection-trapping device, we collected 5 kg of biomass over 13 wk, primarily house flies, from a poultry facility. While a substantial number of pests were removed from the environment, there was no reduction in the fly population. Short-read sequencing was used to compare the bacterial communities carried by flies from differing source populations, and the bacterial species present in the fly samples varied based on farm type and collection time. Drying and milling the wild-caught flies as well as applying an additional heat treatment significantly reduced the number of culturable bacteria present in or on the flies, though their pathogenicity remains unknown. Importantly, these disinfection methods did not affect the nutritional value of the processed flies. Further research is necessary to fully assess the safety and viability of integrating wild-caught insects into livestock feed; however, these data show promising results in favor of such a system.
Lipofibromatosis arising in a right labiocrural fold in a 14-month-old female: a case report study with a 3-year follow-up
Authors: Zvizdic Zlatan , Milisic Emir , Bilalovic Nurija , Ibisevic Nermina , Bukvic Melika , Vranic Semir 
Published: January 2024

Abstract
Lipofibromatosis (LF) is a rare benign fibrofatty tumor of infancy and childhood with a predilection for distal extremities, poor margination, and a high local recurrence rate. We report a toddler who presented with an LF involving her right labiocrural fold. Imaging showed a soft tissue mass extending through the right labiocrural fold with possible infiltration into the underlying muscles. The mass was excised entirely, preserving adjacent structures. The histopathologic report revealed the mass to be LF. A 3-year follow-up revealed no disease recurrence. No other cases of LF in this localization have been presented in the literature. Despite its rarity, LF should be considered in diagnosing soft tissue neoplasms in children. Accurate diagnosis and proper surgical management with complete resection are essential to reduce the postoperative recurrence risk.
The internal structure of medieval Latin legendaries: a computational analysis
Authors: de Valeriola Sébastien , Dubuisson Bastien 
Published: January 2024

Abstract
Since the middle of the 17th century, scholars have been systematically describing numerous medieval manuscripts preserved in libraries and religious institutions that contain hagiographic texts, that is texts recounting the lives of saints. In this article, we apply quantitative tools to the resulting database to consider these codices from a new point of view. As such, we study their internal organization, that is the order in which their texts are arranged. We first present a visualization tool that allows to grasp this structure at a glance. Then, we describe a model to automatically classify manuscripts according to their internal organization, based on a constrained spline regression. The results of this classification task make it possible to identify the manuscripts that have a particular internal organization, called per circulum anni (following the course of the year), and thus to study their properties. Furthermore, they open the possibility to obtain clues regarding the origin of some codices and potential kinship links between them.
Constructing a digital system of historical geographic information from the perspective of digital humanities: a case study of the historical geographic information database of Tibetan Buddhist monasteries
Authors: Chen Danying , Zhao Yaolong , Chao Zihao , Li Yuchen , Fang Subin 
Published: January 2024

Abstract
Digital techniques are critical in the digital age. Research in various disciplines requires the use of digital technology. Extracting and digitizing information from text, particularly historical geographical information, is the most fundamental operation of digital humanities. However, digitizing historical geographical information is a challenging work. This article proposes a framework for constructing a digital system of historical geographic information. The feasibility of the digital system was verified in a case study of Tibetan Buddhist monasteries in Tibetan inhabited areas of China. The results demonstrate that the digital system proposed in this study can be used as a guide for digitizing historical geographic information of Tibetan Buddhist monasteries from the perspective of digital humanities. This study provides a useful reference for the digitalization of historical geographic information in the digital humanities discipline.
Safety and Immune Responses Following Anti-PD-1 Monoclonal Antibody Infusions in Healthy Persons With Human Immunodeficiency Virus on Antiretroviral Therapy
Authors: Gay Cynthia L , Bosch Ronald J , McKhann Ashley , Cha Raymond , Morse Gene D , Wimbish Chanelle L , Campbell Danielle M , Moseley Kendall F , Hendrickx Steven , Messer Michael , Benson Constance A , Overton Edgar T , Paccaly Anne , Jankovic Vladimir , Miller Elizabeth , Tressler Randall , Li Jonathan Z , Kuritzkes Daniel R , Macatangay Bernard J C , Eron Joseph J , Hardy W David ,   for the A5370 Team, Tipton Amanda , Pedersen Susan , Jarocki Bernadette , Anderson Scott , Purdue Lynette , Whitson Kyle , Zabih Sara , Jennings Cheryl , Lankford-Turner Pamela , Mehta Patrick , Uldrick Thomas 
Published: January 2024

Abstract

Background
T cells in people with human immunodeficiency virus (HIV) demonstrate an exhausted phenotype, and HIV-specific CD4+ T cells expressing programmed cell death 1 (PD-1) are enriched for latent HIV, making antibody to PD-1 a potential strategy to target the latent reservoir.

Methods
This was a phase 1/2, randomized (4:1), double-blind, placebo-controlled study in adults with suppressed HIV on antiretroviral therapy with CD4+ counts ≥350 cells/μL who received 2 infusions of cemiplimab versus placebo. The primary outcome was safety, defined as any grade 3 or higher adverse event (AE) or any immune-related AE (irAE). Changes in HIV-1–specific polyfunctional CD4+ and CD8+ T-cell responses were evaluated.

Results
Five men were enrolled (median CD4+ count, 911 cells/μL; median age, 51 years); 2 received 1 dose of cemiplimab, 2 received 2 doses, and 1 received placebo. One participant had a probable irAE (thyroiditis, grade 2); another had a possible irAE (hepatitis, grade 3), both after a single low-dose (0.3 mg/kg) infusion. The Safety Monitoring Committee recommended no further enrollment or infusions. All 4 cemiplimab recipients were followed for 48 weeks. No other cemiplimab-related serious AEs, irAEs, or grade 3 or higher AEs occurred. One 2-dose recipient of cemiplimab had a 6.2-fold increase in polyfunctional, Gag-specific CD8+ T-cell frequency with supportive increases in plasma HIV RNA and decreases in total HIV DNA.

Conclusions
One of 4 participants exhibited increased HIV-1-specific T-cell responses and transiently increased HIV-1 expression following 2 cemiplimab infusions. The occurrence of irAEs after a single, low dose may limit translating the promising therapeutic results of cemiplimab for cancer to immunotherapeutic and latency reversal strategies for HIV.
Clinical Trials Registration. NCT03787095.
Making the EHR Work for You—Modifications of an Electronic Health Record System to Improve Tracking and Management of Patients Receiving Outpatient Parenteral Antibiotic Therapy
Authors: Munsiff Sonal S , Burgoyne Colleen , Dobson Erica , Yamshchikov Alexandra 
Published: January 2024

Abstract

Background
Managing the complex needs of outpatient parenteral antibiotic therapy (OPAT) patients is challenging and time-consuming. We describe development of multimodal interventions to facilitate patient management within an Epic® (Epic Systems Corporation)-based electronic health record (EHR) platform.

Methods
During 2016–2018, a multidisciplinary team created several modifications in our local EHR to improve gaps in OPAT care, including shared note templates, shared patient lists, automatically triggered notifications, and comprehensive order sets. A SmartForm was created, allowing collection of discrete, self-contained extractable data about each OPAT episode. We reviewed OPAT episodes from January 2019 through December 2022.

Results
The multimodal EHR interventions culminated in the creation of a patient report, the “OPAT Monitoring View” collating OPAT-relevant data from multiple sections of the chart onto 1 screen display. This view is accessible both within the patient chart and from multiple list-based, in-basket, and snapshot-anchored preview functions in the EHR. Implementation of the EHR bundle facilitated management of 3402 OPAT episodes from 2019 to 2022 (850 episodes/year), about 50% higher than anticipated based on 540 OPAT courses in 2016. The OPAT EHR bundle allowed efficient (&lt;3 hours) multidisciplinary rounds for management of 130–145 patients each week, streamlining of care transitions, and increasing staff satisfaction.

Conclusions
Bundled multimodal modifications to the local EHR increased patient care efficiency and staff satisfaction and facilitated data collection to support a large OPAT program. These modifications apply commonly available EHR functionalities to OPAT care and could be adapted to other settings with different EHR platforms.
Incidence, Correlates, and Prognostic Significance of Mixed Response in Advanced Non-small Cell Lung Cancer
Authors: Gerber David E , Wang Yating , Ramalingam Suresh S , Bhalla Sheena , Sun Zhuoxin , Borghaei Hossein , Brahmer Julie R , Schiller Joan H 
Published: January 2024

Abstract

Background
Mixed response (MR), a scenario featuring discordant tumor changes, has been reported primarily with targeted therapies or immunotherapy. We determined the incidence and prognostic significance of MR in advanced non–small cell lung cancer (NSCLC) treated with cytotoxic chemotherapy.

Patients and Methods
We analyzed patient-level data from ECOG-ACRIN E5508 (carboplatin-paclitaxel + bevacizumab induction followed by randomization to maintenance therapy regimens). For patients with at least 2 target lesions and available measurements after cycle 2, we characterized response as homogeneous response (HR, similar behavior of all lesions), MR (similar behavior but &gt;30% difference in magnitude of best and least responding lesions), or true mixed response (TMR, best and least responding lesions showing different behavior: ≥10% growth versus ≥10% shrinkage). We compared category characteristics using Mann-Whitney U and Chi-square tests, and overall survival (OS) using log-rank test and Cox models.

Results
Among 965 evaluable patients, HR occurred in 609 patients (63%), MR in 208 (22%), and TMR in 148 (15%). Median OS was 13.6 months for HR, 12.0 months for MR, and 7.6 months for TMR (P &lt; .001). Compared to HR, TMR had inferior OS among stable disease cases (HR 1.62; 95% CI, 1.23-2.12; P &lt; .001) and a trend toward inferior OS among progressive disease cases (HR 1.39; 95% CI, 0.83-2.33; P = .2). In multivariate analysis, TMR was associated with worse OS (HR 1.48; 95% CI, 1.22-1.79; P &lt; .001).

Conclusion
True mixed response occurs in a substantial minority of lung cancer cases treated with chemotherapy and independently confers poor prognosis.
Clinical research progress of novel antituberculosis drugs on multidrug-resistant tuberculosis
Authors: Zhong Xinxin , Lin Ao , Luo Jian , Li Yeqin , Chen Jinlan , Ning Chao , Cao Fu 
Published: January 2024

Abstract
Multidrug-resistant tuberculosis (MDR-TB) has become a critical challenge to public health, and the prevention and treatment of MDR-TB are of great significance in reducing the global burden of tuberculosis. How to improve the effectiveness and safety of chemotherapy for MDR-TB is a pressing issue that needs to be addressed in tuberculosis control efforts. This article provides a comprehensive review of the clinical application of new antituberculosis drugs in MDR-TB, aiming to provide a scientific basis for the prevention and treatment strategy of MDR-TB.
TOPLESS Corepressors as an Emerging Hub of Plant Pathogen Effectors
Authors: Khan Mamoona , Djamei Armin 
Published: January 2024

Transcriptional corepressors form an ancient and essential layer of gene expression control in eukaryotes. TOPLESS and TOPLESS-RELATED (TPL/TPR) proteins constitute a conserved family of Groucho (Gro)/thymidine uptake 1 (Tup1)-type transcriptional corepressors and control diverse growth, developmental, and stress signaling responses in plants. Because of their central and versatile regulatory roles, they act as a signaling hub to integrate various input signaling pathways in the transcriptional responses. Recently, increasing pieces of evidence indicate the roles of TPL/TPR family proteins in the modulation of plant immunity. This is supported by studies on effectors of distantly related pathogens that target TPL/TPR proteins in planta. In this short review, we will summarize the latest findings concerning pathogens targeting plant TPL/TPR proteins to manipulate plant signaling responses for the successful invasion of their hosts. [Formula: see text] Copyright © 2024 The Author(s). This is an open access article distributed under the CC BY-NC-ND 4.0 International license .
A New Method for Creating Impact-Induced Intra-Articular Fractures in a Rabbit Model Induces Severe Post-traumatic Osteoarthritis
Authors: Goetz Jessica E. , Brouillette Marc J. , Sakyi Maxwell Y. , Paulsen Danielle P. , Petersen Emily B. , Fredericks Douglas C. 
Published: January 2024

Objectives:
The objective of this work was to develop a model of intra-articular fracture in a rabbit and document the speed and severity of degenerative joint changes after fracture fixation.

Methods:
With IACUC approval, impact-induced intra-articular fractures were created in the distal tibia of 16 New Zealand White rabbits. Fractures were fixed with a plate and screws. Pain and function were monitored at regular postoperative intervals with limb loading analysis. 12 or 26 weeks after fracture, animals were euthanized for histological assessment of cartilage degeneration and micro-CT analysis of bone histomorphometry.

Results:
Eleven animals successfully completed the study. Maximum foot force in the fractured limb was 41±21% lower than preoperative values (p=0.006) 12 weeks after fracture and remained 25±13% lower (p=0.081) after 26 weeks. Cortical bone mineral density in micro-CT images was 34±13% lower 12 weeks after fracture (p<0.001) and remained (42±8%) lower 26 weeks after fracture (p<0.001). Twelve weeks after fracture, Mankin scores of cartilage degeneration were significantly higher in the medial talus (p=0.007), lateral talus (p<0.001), medial tibia (p=0.017), and lateral tibia (p=0.002) of the fractured limb compared to the uninjured contralateral limb. Average Mankin scores in the talus increased from 12 to 26 weeks (5.9±0.9 to 9.4±0.4; p<0.001 lateral; 5.4±1.8 to 7.8±2.0; p=0.043 medial), indicating substantial and progressive joint degeneration.

Conclusions:
The ankle joint of the New Zealand White rabbit provides the smallest available model of impact-induced intra-articular fracture that can be treated with clinically relevant techniques and replicates key features of healing and degeneration found in human patients.
Early acetabular fracture repair through an anterior approach is associated with increased blood loss
Authors: Ambrose Michael , Schulman Jeff E. , Kuenze Christopher , Hymes Robert A. , Holzman Michael , Malekzadeh A. Stephen , Ray-Zack Mohamed , Gaski Greg E. 
Published: January 2024

OBJECTIVES:
To determine whether the timing of acetabular fracture fixation through an anterior approach influences estimated and calculated perioperative blood loss.

METHODS:

Design:
Retrospective cohort study.

Setting:
Level 1 trauma center from 2013 to 2021.

Patient Selection Criteria:
Patients age >18 treated with acetabular fracture fixation through an anterior-based approach.

Outcome Measures and Comparisons:
The primary outcome was calculated blood loss (CBL). Secondary outcomes were estimated blood loss (EBL) reported by surgeon and anesthesia, and blood transfusion requirements. Comparisons of blood loss were made at discrete post-injury time thresholds (24, 36, and 48 hours) and on a continuous basis.

RESULTS:
108 patients were studied. The mean age was 65 and 73% of patients were male. Earlier fixation of acetabular fractures resulted in greater CBL and EBL (surgeon and anesthesia) compared to later fixation when analyzed on a continuum and at specific time points (24, 36, and 48 hours). Mean CBL in patients treated earlier (< 48hrs, 2539 ml +/-1194) was significantly greater than those treated later (>48 hrs, 1625 ml +/-909; p<0.001). Fracture repair before 48 hours post-injury was associated with a 3 times greater risk of >2000 ml of CBL (p=0.006). This did not result in differences in transfusion rates between groups at 24 hours (p=0.518), 36 hours (p=1.000) or 48 hours (p=0.779).

CONCLUSIONS:
Delaying fixation of acetabular fractures treated through an anterior approach for 48 hours post-injury may significantly reduce perioperative blood loss.

LEVEL OF EVIDENCE:
Therapeutic Level III. See Instructions for Authors for a complete description of levels of evidence.
Risk factors for spinal cord injury without radiographic abnormality in trauma cases at a single trauma center
Authors: Taira Takayuki , Morita Seiji , Miyakawa Sachiko , Nakagawa Yoshihide , Umemura Takehiro , Inokuchi Sadaki 
Published: January 2024

Abstract

Background
Cervical injury due to blunt trauma requires emergency responses; however, few studies have investigated risk factors based on spinal cord injury without radiographic abnormality (SCIWORA). Therefore, this study determined the risk factors for cervical spinal cord injury with radiographic abnormality and SCIWORA.

Materials and Methods
This study included 4923 trauma cases transferred to a Japanese trauma center between 2007 and 2013. We analyzed risk factors for cervical spinal cord injury with radiographic abnormality and SCIWORA using a logistic regression model. The coefficient factors considered for this study were Revised Trauma Score, age at arrival, and cause of injury (traffic accident, ground-level fall, low- and high-level fall, or other injury).

Results
Significant independent risk factors of cervical spinal cord injury varied based on the presence or absence of radiographic abnormality. The risk factors for SCIWORA were male (odds ratio [OR], 2.19; 95% confidence interval [CI], 1.21–3.95), age 65 to 79 years (OR, 1.71; CI, 1.06–2.78), Revised Trauma Score <7.8408 (OR, 4.98; CI, 2.42–10.26), Injury Severity Scale (OR, 1.07; CI, 1.06–1.09), other injuries (OR, 2.64; CI, 1.11–6.30), low- and high-level fall (OR, 2.18; CI, 1.24–3.83), and ground-level fall (OR, 10.35; CI, 5.65–18.95).

Conclusions
The risk factors for SCIWORA are male, age 65 to 79 years, and ground-level fall. Therefore, careful neurologic examination and magnetic resonance imaging studies are necessary in the examination of these at-risk patients.
Efficacy and safety of biologics in primary sclerosing cholangitis with inflammatory bowel disease: A systematic review and meta-analysis
Authors: Shah Ayesha , Jones Michael P. , Callaghan Gavin , Fairlie Thomas , Ma Xiaomin , Culver Emma L. , Stuart Katherine , De Cruz Peter , O’Beirne James , Tabibian James H. , Dignass Axel , Canbay Ali , Gores Gregory J. , Holtmann Gerald J. 
Published: January 2024

Background:
Primary sclerosing cholangitis (PSC) is an immune-mediated, chronic cholestatic liver disease. Currently, liver transplantation is the only established life-saving treatment. Several studies have evaluated the effect of different biologic therapies on PSC with inconclusive findings. We conducted a systematic review and meta-analysis to assess the effects of biologics in PSC and associated inflammatory bowel disease (IBD).

Methods:
MEDLINE, Scopus, and Embase were searched up to July 31, 2023, for studies reporting the effects of biologics in patients with PSC-IBD. Effects of biologic therapy on alkaline phosphatase, total bilirubin, ulcerative colitis response score, and adverse events were calculated and expressed as standardized difference of means (SMD), proportions, and 95% CI using a random-effects model.

Results:
Six studies, including 411 PSC-IBD patients who received biologics, were included. Biologic treatment was associated with no change in alkaline phosphatase (SMD: 0.1, 95% CI: −0.07 −0.17, p=0.43), but a small and statistically significant increase in total bilirubin (SMD: 0.2, 95% CI: 0.05–0.35, p<0.01). 31.2% (95% CI: 23.8–39.7) of patients with IBD achieved endoscopic response, and there was a significant improvement in ulcerative colitis response score (SMD: −0.6,95% CI: −0.88 to 0.36, p<0.01). Furthermore, 17.6% (95% CI: 13.0–23.5) of patients experienced adverse events severe enough to discontinue therapy, and 29.9% (95% CI: 25.2–34.8) had a loss of response to biologics.

Conclusions:
Treatment of patients with PSC-IBD with biologics (vedolizumab, infliximab, and adalimumab) was not associated with improvement of biochemical markers of cholestasis. Biologics are effective in treating the colitis associated with PSC. Vedolizumab was associated with worsening liver enzymes in contrast to other biologics, a finding that warrants further study.