bluuebunny/crossref_metadata_2025_split huggingface dataset:
Phase 3 KEYNOTE-676 cohort A: Bacillus Calmette-Guérin (BCG) with or without pembrolizumab for high-risk (HR) non–muscle-invasive bladder cancer (NMIBC) that persists/recurs after BCG induction.
Authors: Shore Neal D. , Nishiyama Hiroyuki , Shariat Shahrokh F. , Steinberg Gary , Kamat Ashish M. , Alanee Shaheen Riadh , Nam Kijoeng , Imai Kentaro , Kapadia Ekta , Hahn Noah M. 
Published: January 2024

TPS722 Background: Intravesical instillation of BCG is a standard-of-care treatment for patients with HR NMIBC, but up to 50% of patients later experience disease recurrence or progression to muscle-invasive bladder cancer (MIBC) despite BCG treatment. In the phase 2 KEYNOTE-057 study (NCT02625961), pembrolizumab monotherapy was shown to have antitumor activity in patients with HR BCG–unresponsive NMIBC who had carcinoma in situ (CIS) with or without papillary tumors and in patients with only papillary tumors. In cohort A of the randomized, phase 3 KEYNOTE-676 trial (NCT03711032), pembrolizumab plus BCG versus BCG alone is being evaluated in patients with persistent/recurrent HR NMIBC after first BCG induction. Methods: Key eligibility criteria include adults with histologically confirmed HR NMIBC (T1, high-grade Ta, and/or CIS) that is persistent/recurrent following 1 adequate course of BCG induction therapy, have no concurrent extravesical disease or history of extravesical disease that recurred within 2 years, have an ECOG PS score of 0 to 2, and have undergone cystoscopy/TURBT ≤12 weeks before randomization. Approximately 430 patients will be randomly assigned 1:1 to receive pembrolizumab 200 mg intravenously every 3 weeks plus BCG or BCG alone. BCG (50 mg) will be administered by intravesical instillation as induction therapy once weekly for 6 weeks and then as maintenance therapy once weekly for 3 weeks at weeks 13 and 25, then every 24 weeks (Q24W) thereafter. Treatment will continue for approximately 2 years (pembrolizumab) or 3 years (BCG), or until confirmed persistent/recurrent HR NMIBC or disease progression to MIBC or metastatic bladder cancer, unacceptable toxicity, or withdrawal. Randomization to treatment will be stratified by PD-L1 combined positive score (≥10 or ˂10), histology (CIS or non-CIS), and NMIBC disease history (persistence/recurrence 0 to ≤6 months or recurrence ˃6 to ≤12 months or recurrence ˃12 to ≤24 months). Response will be assessed by local cystoscopy and blinded independent central review of urine cytology and biopsy (as applicable) every 12 weeks for years 1 to 2 and Q24W for years 3 to 5. Computed tomography urography will occur every 72 weeks through year 5, then every 104 weeks thereafter. The primary end point is complete response rate in patients with CIS. Secondary end points are duration of response in patients with CIS, event-free survival, recurrence-free survival, time to cystectomy, overall survival, disease-specific survival, safety and tolerability, and patient-reported outcomes. Enrollment incohort A of KEYNOTE-676 is ongoing in Asia, Australia, Europe, and North America. Clinical trial information: NCT03711032 .
Efficacy and safety of the combination of cisplatin plus nab-paclitaxel and nivolumab with radiotherapy after maximal tumor resection in non-metastatic muscle invasive bladder cancer (CNN-BC trial).
Authors: Ciccarese Chiara , Iacovelli Roberto , Alitto Anna Rita , Anghelone Annunziato , Sparagna Ileana , Tagliaferri Luca , Palermo Giuseppe , Racioppi Marco , Tortora Giampaolo 
Published: January 2024

TPS723 Background: The therapeutic gold standard for muscle invasive bladder cancer (MIBC) is radical cystectomy (RC) preceded by neoadjuvant chemotherapy when appropriate. However, RC is a major surgery procedure with 13% rate of severe complication and a perioperative mortality rate of about 1.5 - 5 %. Trimodal therapy (TMT) is a “bladder sparing” option alternative to RC. TMT consists of complete transurethral bladder tumor resection (TURBT) followed by a combination of systemic chemotherapy and locoregional radiotherapy (RT), with the option of “salvage” cystectomy in case of local treatment failure. Immunotherapy with anti-PD1/PD-L1 monoclonal antibody significantly improves survival of metastatic BC patients, and it seems to potentiate the activity of RT without increased toxicity. Therefore, we investigate the role of a multimodal TMT strategy to increase the disease-free survival (DFS) and avoid or delay RC in non-metastatic MIBC pts. Methods: CNN-BC trial (NCT05203913) is a phase 2, open-label, mono-institutional study evaluating the activity and safety of TMT with cisplatin, nab-paclitaxel and nivolumab as systemic therapy in non-metastatic MIBC pts. Eligible pts should have undergone complete TURBT with diagnosis of T2-T3 N0M0 urothelial carcinoma, and no evidence of lymph nodes or metastatic disease at FDG-PET within 6 weeks from the start of treatments. TMT consists of nivolumab (480 mg IV every 4 weeks for a total of 13 doses), weekly nab-paclitaxel (60mg/m2) plus cisplatin (20mg/m2) administered concurrently with RT (60Gy in 25 fractions over 5 weeks on original bladder tumor, plus a concomitant boost of 50Gy in 25 fractions on whole bladder and pelvic nodes). The primary endpoint is the 1-year DFS rate, defined as the rate of survival free of recurrence in pelvic nodes or bladder, or appearance of distant metastases. Secondary endpoints include: the rate of pts who require salvage cystectomy, the rate of locoregional complete response (CR) and of locoregional DFS, median DFS, safety, and quality of life. Exploratory biomarkers analysis will be performed. The trial is actively recruiting. Clinical trial information: NCT05203913 .
STUDYING THE POTENTIAL OF THE REPUBLIC OF BASHKORTOSTAN FOR THE DEVELOPMENT OF INTERREGIONAL INTERACTION
Authors: Biglova Alfiya A. 
Published: January 2024

In order to increase the competitiveness of the region and the competent distribution of production forces, leveling the socio-economic and financial imbalance in modern conditions accompanied by external pressure and instability of economic development, there is a growing need to focus on increasing the efficiency of using potential of the region.
Purpose. study of the potential of the Republic of Bashkortostan to expand interregional cooperation
Methodology in the process of writing the article, theoretical methods of analysis and synthesis, generalization and classification were used. The information basis of the study was normative and methodological sources, legislative acts of the Russian Federation, data from official government websites of the Russian Federation, educational and specialized literature, periodicals in the field of regional development, interregional interaction, as well as statistical data.
Results: informative data was obtained reflecting aspects of the development of interregional interaction
Practical implications it is advisable to apply the obtained results in order to develop and improve the quality of management decisions in the formation of interregional interaction for the sustainable economic development of the country.
IMPROVEMENT OF THE SYSTEM OF MATERIAL AND TECHNICAL SUPPORT OF METAL ROLLING AT MACHINE-BUILDING ENTERPRISES
Authors: Isavnin Alexey G. , Nizamova Liliya N. , Frolova Olga N. 
Published: January 2024

Material and technical support is an important stage in the production activity of the enterprise, since the competent organization of this process directly affects the cost of the final product. The procedure for registering receipts, taking into account the use of information systems, as well as electronic document management, involves a certain sequence of steps from the moment of arrival at the warehouse to transfer to production. An efficiently built process allows you to eliminate storage costs, failures in logistics flows, duplication of information. The peculiarity of the system of material and technical support of metal rolling enterprises of the machine-building industry implies a delay in obtaining in the primary documents necessary for the prompt registration of receipt in the system and transfer of goods to production. This article discusses a new format of interaction with metal suppliers, proposes a new procedure for registering the receipt of rolled metal on the basis of quality certificates from the processor. The essence of this innovative approach is to register receipt with reference to the number of the processor's certificate, since it contains all the necessary information for acceptance by quantity and quality. To automate the signing of electronic primary documents based on the reconciliation of data in an electronic document, it is necessary to define a new tag to indicate the certificate number. Thus, a link will be established between the incoming delivery in the buyer's system and the supplier's electronic document for automatic electronic signing.
Purpose. Optimization of the process of material and technical support by metal rolling for enterprises of the machine-building industry.
Methodology: the article used survey, analysis, comparison, modeling.
Results: new procedure for registering the receipt of rolled metal products on the basis of quality certificates from the processor, which allows avoiding storage costs, errors in duplicating information.
Practical implications it is advisable to apply the obtained results for enterprises of the machine-building industry engaged in the purchase of rolled metal.
Chronic Pelvic Pain Syndrome among women - challenge in diagnostics and management. Current literature review
Authors: Zielińska Zuzanna , Nowak Karolina , Olejarz Zuzanna , Drygała Zuzanna , Wyrwał Julia , Słowik Magdalena , Nowak Karolina , Nieć Maria , Gierlach Katarzyna , Krasuska Martyna 
Published: January 2024

Introduction and purpose:
Chronic Pelvic Pain Syndrome (CPPS) is characterized as intermittent or constant pain located in the lower abdomen or pelvis, persisting continuously for at least 6 months [1]. Reports on the prevalence of chronic pelvic pain indicate the occurrence of this condition at a level of 5.7–26.6% in women of reproductive age. However, only a third of women suffering from chronic pelvic pain, seek medical care [2].
Clinical picture of CPPS consists of various patterns and symptoms, often as the intersection of the multiple systems, which additionally complicates and delays the diagnostic process.
The aim of this review is to summarize existing literature about the diagnostics and management of Chronic Pelvic Pain Syndrome among women and create an awareness about the challenges which this condition poses for healthcare professionals.
A brief description of the state of knowledge:
Chronic Pelvic Pain Syndrome is a multifaceted condition and the pathophysiology of it has not yet been comprehensively studied. Clinical picture often involves dysfunctions in pelvic floor, urinary tract, or gastrointestinal system. Treatment involves a multidisciplinary approach including non-pharmacological and pharmacological interventions.
Summary (conclusions):
Chronic Pelvic Pain is a complex condition involving symptoms affecting the psychological, gastrointestinal, musculoskeletal systems. The most successful treatment approach emphasizes the role of collaboration among a diverse team of specialists such as gynecologists, gastroenterologists, psychiatrists, psychologists, and physiotherapists. More research focused on multimodal strategies in management of the CPP is needed to match patients most effectively with the most suitable combination of treatment and reduce the systemic consequences of chronic pain.
Use of Machine Learning Models to Warmstart Column Generation for Unit Commitment
Authors: Sugishita Nagisa , Grothey Andreas , McKinnon Ken 
Published: January 2024

The unit commitment problem is an important optimization problem in the energy industry used to compute the most economical operating schedules of power plants. Typically, this problem has to be solved repeatedly with different data but with the same problem structure. Machine learning techniques have been applied in this context to find primal feasible solutions. Dantzig-Wolfe decomposition with a column generation procedure is another approach that has been shown to be successful in solving the unit commitment problem to tight tolerance. We propose the use of machine learning models not to find primal feasible solutions directly but to generate initial dual values for the column generation procedure. Our numerical experiments compare machine learning–based methods for warmstarting the column generation procedure with three baselines: column prepopulation, the linear programming relaxation, and coldstart. The experiments reveal that the machine learning approaches are able to find both tight lower bounds and accurate primal feasible solutions in a shorter time compared with the baselines. Furthermore, these approaches scale well to handle large instances. History: Accepted by Andrea Lodi, Area Editor for Design & Analysis of Algorithms—Discrete.
media relations of Universitas Ahmad Dahlan Yogyakarta in maintaining image during the COVID-19 Pandemic
Authors: Pratiwi Nadia , Anisa Sari Eka 
Published: January 2024

The COVID-19 pandemic in 2021 has affected the education in Indonesia, including the institution of Universitas Ahmad Dahlan (UAD) Yogyakarta. The existence of educational institutions requires existence to gain the trust of the community. Public relations become an element that plays a role. During the COVID-19 pandemic, the use of media helps the public in obtaining and conveying information, including media coverage. Therefore, it is important for university public relations to have a good relationship with the media, considering that the media is a source of information providers. This study aims to determine the implementation of media relations carried out by UAD Public Relations in maintaining its image during the COVID-19 pandemic in 2021. The goal is to know and understand the implementation of media relations applied, starting from the research stage, preparation, communicating a program, and evaluations. This research method uses a qualitative with a case study approach and was analyzed using John E. Marston's R-A-C-E Formula. Based on data, at the research stage the implementation is not maximized, so that offline activities have no substitute activities. At the action stage, media relations activities include preparation of public relations writing skills, release materials, and advertising publication materials. Stages of communication conducting media relations activities, namely making press releases and advertising publications. In addition, to build a good relationship with the media, UAD Public Relations maintains personal contact with media partners, provides souvenirs, and Feast Day gifts. Finally, at the evaluation stage, UAD Public Relations monitors publications and program evaluation.
3D power frequency intensive electric field sensor based on a lithium niobate electro-optic crystal
Authors: Zhang Jiahong , Chen Zewen , Lei Hongyi 
Published: January 2024

In order to conveniently measure the power frequency intensive electric field in any
direction in space, a lithium niobate (LN) crystal-based three
dimensional (3D) intensive electric field sensor with an
all-dielectric structure has been developed. A regular triangular
prism structure with three 1D (one-dimensional) electric field sensors
fixed on its three sides is designed and fabricated. By setting the
orientation of the z-axes of the three 1D electric field
sensors at 54.7° with respect to the three edges of the prism, the
detection directions of the three 1D electric field sensors are
perpendicular to each other. Compared to existing 3D electric field
sensors that directly arrange three 1D electric field sensors along
three mutually perpendicular directions, the overall device volume of
the newly designed 3D sensor is significantly reduced. Experimental
results reveal that the linear measurement ranges of the 3D electric
field sensor along the three axes are
3.71 kV/m–388 kV/m, 2.78 kV/m–403 kV/m,
and 4.50 kV/m–375 kV/m, respectively. When the electric
field strength is 82.05 kV/m, the measurement error is less
than 4.97% when the 3D electric field sensor is rotated 360° in the yoz and xoy planes.
Building Back Truth in an Age of Misinformation, Leslie Stebbins (2023)
Authors: Lawson Brendan T 
Published: January 2024

Review of: Building Back Truth in an Age of Misinformation, Leslie Stebbins (2023)
Lanham, MD: Rowman & Littlefield Publishers, 206 pp.,
ISBN 978-1-53816-314-6, h/bk, £25.00
Kemandirian Perempuan Pedesaan dalam Menentukan Pilihan Politik di Ranah Pemilihan Kepala Desa: Studi Perilaku Memilih dari Dimensi Sosiologi dan Psikologi
Authors: Kushandajani Kushandajani , Fitriyah Fitriyah , Alfirdaus Laila Kholid , Martini Rina 
Published: January 2024

Suara pemilih perempuan pedesaan jumlahnya cukup signifikan, tetapi dipertanyakan kualitas. Riset ini dilakukan dalam rangka menjawab pertanyaan seberapa mandiri perempuan perdesaan dalam menentukan pilihan politiknya, melalui dimensi sosiologi dan psikologi. Teori perilaku memilih dari dua dimensi tersebut diterapkan untuk menjelaskan perilaku pemilih perempuan dalam konteks pemilihan kepada desa. Riset ini menggunakan dimensi sosiologi yang berisi variabel kondisi sosial ekonomi, agama, dan afiliasi sosial politik serta serta pengaruh keluarga/lingkungan. Adapun dimensi psikologis mencakup variabel sikap, persepsi, emosi, dan perilaku yang ditujukan kepada kandidat kepala desa perempuan. Penggunaan metode kuantitatif dirasa tepat karena bertujuan mengukur tingkat persepsi pemilih perempuan dalam menentukan pilihan di ranah pemilihan kepala desa. Hasil riset menunjukkan perilaku politik perempuan dalam pilkades tidak diputuskannya secara mandiri, melainkan menggunakan referensi panutannya yakni figur laki-laki yang menjadi rujukan baik dalam keluarga maupun lingkungan sosio-kultural. Ketergantungan ini berimplikasi pada batasan psikologis pemilih perempuan kepada kandidat kepala desa perempuan.
Review on the screening of urine glucose for early diagnosis of type 2 diabetes mellitus in school children and adolescents with obesity in Hong Kong
Authors: Pang Gloria Shir-Wey , Chung Thomas Wai-Hung , Choy Heather Hiu-Ting , Lee Ching-Yin , Tung Joanna Yuet-Ling , Fu Antony Chun-Cheung , Tsang Jennifer Wing-Yan , Yau Ho-Chung , Belaramani Kiran M. , Wong Lap-Ming , But Betty Wai-Man , Chow Jasmine Chi-Kwan , Wong Shirley Man-Yee , Cheung Patrick Chi-Hung , Lo Priscilla Wai-Chee , Ng Kwok-Leung , Poon Sarah Wing-Yiu , Chan Kwong Tat , Chan Angela Mo-Kit , Wong Sammy Wai-Chun , Tay Ming-Kut , Chung Ying-Ki , Lam Yuen-Yu , Kwan Elaine Yin-Wah 
Published: January 2024

Abstract

Objectives
Obesity and type 2 diabetes mellitus (T2DM) are growing health concerns. Since 2005, Student Health Service (SHS) and Hong Kong Paediatric Society formulated a protocol on urine glucose screening (UGS) for early diagnosis of T2DM in students with obesity in Hong Kong. This study reviews students with T2DM captured by this screening program and compare the data with the Hong Kong Children Diabetes Registry (HKCDR) database, to see if the UGS program facilitates early diagnosis of T2DM.

Methods
Students between the ages of 10–18 years old with age- and sex-specific body mass index (BMI) >97th percentile who attended SHS between the school years from 2005/06 to 2017/18 were recruited for UGS. Those tested positive for random urine glucose underwent diagnostic testing for T2DM according to ADA guidelines. Demographic data and investigatory results from UGS and HKCDR within the same time period were compared.

Results
A total of 216,526 students completed UGS in the said period; 415 (0.19 %) students were tested positive for urine glucose of which 121 students were diagnosed with T2DM. UGS picked up 23 % of the newly diagnosed T2DM cases. When compared to the HKCDR database, students diagnosed via UGS were significantly younger, less obese, and had fewer diabetic related complications. The negative predictive value of UGS is high and can effectively rule out T2DM.

Conclusions
Urine glucose screening is an inexpensive and simple test that allows for early diagnosis of T2DM among obese school students. Other methods including POCT HbA1c can be explored to improve program effectiveness.
Cringe witnessing in post-millennial stand-up comedy performances by Ali Wong and Ali Quandil
Authors: Elshazly Deena Shazly 
Published: January 2024

Abstract
Cringe comedy, wittily disseminating truth through the interplay between the verbal and contextual, centralizes vicarious/embarrassment as its endpoint through levels of para/linguistic incongruity and social superiority. This paper focuses on the stand-up comedian presentation along with paratextual elements that document the sociopolitical situation in two different cultures contributing to the process of perception on the part of the gazing audience. The paper questions the spectatorial gaze through post-millennial media practices that pertain to the visual among other visceral affects thus diminishing the role of the active witness whose role is beyond watching. The act of witnessing, globally foregrounded and requested by the turn of the twenty-first century, is investigated within the structure of stand-up comedy to figure out whether or not the spectator is an active witness or a by-stander. For this purpose, the study applies Andy Lavender’s model of performance modalities to stand-up comedy performances by the American Ali Wong and the Egyptian Ali Quandil; Don Wong and Mawdoa Hareemi Shweya (Some Feminine Stuff) in 2022 and 2021 respectively. Lavender’s model proposes that four modalities (the emotional, physical, discursive, contextual) turn the actor/performer into the physical medium of communication to the audience.
RADIOPHARMACEUTICAL RENAL DOSIMETRY USING SNYDER / CRISTY-ECKERMAN / SEGARS ANTHROPOMORPHIC REPRESENTATIONS
Authors: Vasquez Marcial V. , Vega Héctor R. , Acuña Santos L. , Rodriguez Huber E. , Vasquez Marcela A. , Flores Hipólito F. , Tantaquispe Santos M. 
Published: January 2024

Absorbed doses to the kidneys of adult patients are estimated using the Medical Internal Radiation Dosimetry (MIRD) methodology and the anthropomorphic representations of Snyder, Cristy-Eckerman, and Segars. The radiopharmaceuticals 99mTc(DTPA), 99mTc(DMSA) and 99mTc(MAG3) are used to perform renal function studies in adults. The dose results found for these radiopharmaceuticals and their representations will allow the exploring of their dosimetric impact on each other. The relative difference in total renal dose by using the Snyder/Segars and Cristy-Eckerman/Segars anthropomorphic-representations was 3.6% and 0.3% when using 99mTc(DMSA); 2.9% and 3.0% when using 99mTc(MAG3); 5.0% and 1.5% when using 99mTc(DTPA). Regardless of the radiopharmaceutical selected, the substitution of Segars phantoms for Snyder or Cristy-Eckerman phantoms does not reflect significant changes in the estimated absorbed dose to the kidneys.