bluuebunny/crossref_metadata_2025_split huggingface dataset:
Cardiovascular Rehabilitation With a WCD—Data From the CR3 Study (Cardiac Rehab Retrospective Review)
Authors: Rohrer Ursula , Reischl Anja , Manninger Martin , Binder Ronald K. , Fiedler Lukas , Gruska Michael , Altenberger Johann , Dorr Andreas , Steinwender Clemens , Stuehlinger Markus , Wonisch Manfred , Zirngast Birgit , Zweiker David , Zirlik Andreas , Scherr Daniel 
Published: November 2023

Purpose:
Patients at risk for sudden cardiac death may temporarily need a wearable cardioverter-defibrillator (WCD). Exercise-based cardiac rehabilitation (CR) has a class I recommendation in patients with cardiac disease. The aim of this study was to evaluate the safety and feasibility of undergoing CR with a WCD.

Methods:
We performed a retrospective analysis of all patients with a WCD who completed a CR in Austria (2010-2020).

Results:
Patients (n = 55, 60 ± 11 yr, 16% female) with a median baseline left ventricular ejection fraction (LVEF) of 36 (30, 41)% at the start of CR showed a daily WCD wearing duration of 23.4 (22, 24) hr. There were 2848 (8 [1, 26]/patient) automatic alarms and 340 (3 [1, 7]/patient) manual alarms generated. No shocks were delivered by the WCD during the CR period. One patient had recurrent hemodynamically tolerated ventricular tachycardias that were controlled with antiarrhythmic drugs.
No severe WCD-associated adverse events occurred during the CR stay of a median 28 (28, 28) d. The fabric garment and the device setting needed to be adjusted in two patients to diminish inappropriate automatic alarms. Left ventricular ejection fraction after CR increased significantly to 42 (30, 44)% (P < .001). Wearable cardioverter-defibrillator therapy was stopped due to LVEF restitution in 53% of patients. In 36% of patients an implantable cardioverter-defibrillator was implanted, 6% had LVEF improvement after coronary revascularization, one patient received a heart transplantation (2%), two patients discontinued WCD treatment at their own request (4%).

Conclusion:
Completing CR is feasible and safe for WCD patients and may contribute positively to the restitution of cardiac function.
Relationship Between Extreme Pain Phenotypes and Psychosocial Outcomes in Persons With Chronic Pain Following Traumatic Brain Injury: A NIDILRR and VA TBI Model Systems Collaborative Project
Authors: Ketchum Jessica M. , Hoffman Jeanne M. , Agtarap Stephanie , Hammond Flora M. , Martin Aaron M. , Walker William C. , Zafonte Ross , Harrison-Felix Cynthia , Nakase-Richardson Risa 
Published: November 2023

Objective:
To examine the relationship between extreme pain phenotypes (interference and improvement) and psychosocial outcomes among those with chronic pain after traumatic brain injury (TBI).

Setting:
Community.

Participants:
In total, 1762 TBI Model Systems (TBIMS) participants 1 to 30 years postinjury reporting chronic pain.

Design:
Multisite, cross-sectional, observational cohort study.

Primary Measure(s):
Life satisfaction, posttraumatic stress, depression and anxiety symptoms, sleep and participation, the Brief Pain Inventory (BPI) interference scale, and the Patient's Global Impression of Change (PGIC).

Results:
Persons in the extreme high interference phenotype (vs extreme low interference phenotype) and/or extreme no change phenotype (vs extreme improvement phenotype) had poorer psychosocial outcomes, with extreme pain interference phenotypes having a larger effect on outcomes than extreme perceived improvement phenotypes. After controlling for covariates, large effect sizes (ES) related to pain interference were observed for posttraumatic stress symptoms (ES = −1.14), sleep quality (ES = −1.10), depression (ES = −1.08), anxiety (ES = −0.82), and life satisfaction (ES = 0.76); effect sizes for participation outcomes, although significant, were relatively small (ES = 0.21-0.36). Effect sizes related to perceived improvement were small for life satisfaction (ES = 0.20) and participation (ES = 0.16-0.21) outcomes. Pain intensity was identified as a meaningful confounding factor of the relationships between extreme phenotypes and posttraumatic stress, depression, anxiety, and sleep quality.

Conclusions:
Examination of extreme phenotypes provides important insights into the experience of individuals living with chronic pain and TBI. Results suggest that the relationships among a variety of characteristics of the person, their experience with pain, and treatment of pain are complex. Further research is needed to better understand these complex relationships and how differences in pain interference and perceived improvement from treatment can assist in assessment and treatment of chronic pain after TBI.
Exercising More Than 150 min/wk After Concussion Is Associated With Sleep Quality Improvements
Authors: Howell David R. , Wingerson Mathew J. , Smulligan Katherine L. , Magliato Samantha , Simon Stacey , Wilson Julie C. 
Published: November 2023

Objective:
To examine whether a high volume of aerobic exercise after concussion (>150 min/wk) is associated with improved sleep quality over a 1-month period. We hypothesized that more than 150 min/wk of exercise would be associated with improved sleep quality across concussion recovery.

Design:
Prospective cohort observational study.

Setting:
Sports medicine clinic.

Participants:
Adolescents initially tested 8.4 ± 3.5 (range, 2-18) days postconcussion who returned for a follow-up assessment 34.3 ± 7.7 (range: 20-49) days postconcussion.

Main Outcome Measures:
Participants completed the Pittsburgh Sleep Quality Index and the Post-Concussion Symptom Inventory. No specific exercise or sleep recommendations were given beyond what their treating physician provided. Between study visits, participants recorded exercise performed via wrist-worn actigraphy. We calculated average exercise minutes per week and grouped participants as those who exercised more than 150 min/wk versus those who exercised 150 min/wk or less.

Results:
Thirty-six adolescents participated. Fifteen (42%) recorded more than 150 min/wk of aerobic exercise (age = 14.0 ± 1.7 years; 47% female; mean = 5.6 ± 1.2 d/wk of exercise; mean = 49.2 ± 17.5 min/session), and 21 recorded 150 min/wk or less of aerobic exercise (age = 15.0 ± 1.9 years; 76% female; mean = 2.7 ± 1.6 d/wk of exercise; mean = 30.2 ± 7.8 min/session). There were no significant group differences in the proportion of those who self-reported beginning physical activity prior to enrollment (47% vs 33%; P = .42) or for initial sleep quality rating (8.0 ± 3.7 vs 8.6 ± 4.1; P = .67) or initial concussion symptom severity rating (34.9 ± 28.0 vs 42.6 ± 25.9; P = .40). The group that exercised more than 150 min/wk between visits demonstrated significantly greater median PSQI rating improvements than those who exercised 150 min/wk or less, with a large effect size noted (median change [interquartile range] = 5 [3, 7] vs 1 [0, 4]; P = .008; Cohen d = 0.96).

Conclusion:
Current recommendations suggest that subsymptom aerobic exercise can be beneficial after concussion. Our findings indicate that an exercise volume of more than 150 min/wk led to greater sleep quality improvements than those who exercised below this level.
Emerging phenotypes in kidney transplant rejection
Authors: Mengel Michael , Adam Benjamin A. 
Published: November 2023

Purpose of review
This review focuses on more recently emerging rejection phenotypes in the context of time post transplantation and the resulting differential diagnostic challenges. It also discusses how novel ancillary diagnostic tools can potentially increase the accuracy of biopsy-based rejection diagnosis.

Recent findings
With advances in reducing immunological risk at transplantation and improved immunosuppression treatment renal allograft survival improved. However, allograft rejection remains a major challenge and represent a frequent course for allograft failure. With prolonged allograft survival, novel phenotypes of rejection are emerging, which can show complex overlap and transition between cellular and antibody-mediated rejection mechanisms as well as mixtures of acute/active and chronic diseases. With the emerging complexity in rejection phenotypes, it is crucial to achieve diagnostic accuracy in the individual patient.

Summary
The prospective validation and adoption of novel molecular and computational diagnostic tools into well defined and appropriate clinical context of uses will improve our ability to accurately diagnose, stage, and grade allograft rejection.
Psychosocial Adjustment Experiences Among Nasopharyngeal Carcinoma Survivors
Authors: Jiang Jie , Yan Ming-Hui , Fan Yu-Ying , Zhang Jun-E 
Published: November 2023

Background
Nasopharyngeal carcinoma (NPC) has serious effects on the daily lives and psychosocial adjustment of survivors. In particular, psychosocial problems are a prominent concern.

Objective
The aim of this study was to understand the lived experiences of NPC survivors regarding psychosocial adjustment.

Methods
A qualitative design using individual semistructured interviews was conducted with 20 NPC survivors. Each participant was asked open-ended questions about their lived experience with psychosocial adjustment. The data were then subjected to thematic analysis.

Results
The following 4 themes, which had subthemes, were identified from the data: (1) grappling with discomforts (symptoms distress of late toxicities, impaired body image, and returning-to-work restrictions), (2) struggling with uncertainty (disease attribution with self-blame, contradictory rehabilitation information, fear of cancer recurrence, and distance from medical staff), (3) changing social patterns (special favors, social isolation, and social discrimination), and (4) cultivating positive change (healthy lifestyle and positive mindset).

Conclusions
Nasopharyngeal carcinoma survivors experience many obstacles, as well as positive changes, during psychosocial adjustment. This study highlights the pressing need to consider NPC survivors’ concerns about their psychosocial adjustment.

Implications for Practice
Medical staff should provide NPC survivors with sufficient rehabilitation information to help them deal with possible late toxicities and mitigate their uncertainty and misunderstanding. Effective public education measures are needed to address misunderstandings about cancer in Chinese cultural settings.
Localized and Widespread Chronic Pain in Sexual and Gender Minority People – An Analysis of The PRIDE Study
Authors: Chadwick Andrea L. , Lisha Nadra E. , Lubensky Micah E. , Dastur Zubin , Lunn Mitchell R. , Obedin-Maliver Juno , Flentje Annesa 
Published: November 2023

AbstractSex related differences, without taking gender into account, in chronic pain have been widely researched over the past few decades in predominantly cisgender and heterosexual populations. Historically, chronic pain conditions have a higher incidence and prevalence in cisgender women, including but not limited to fibromyalgia, irritable bowel syndrome, and migraine. The goal of the present study was to identify and characterize the presence and characteristics of chronic pain in SM and GM persons using data from The PRIDE Study, which is the first large-scale, long-term national cohort health study of people who identify as lesbian, gay, bisexual, transgender, queer, or as another sexual or gender minority person. A total of 6189 adult participants completed The PRIDE Study 2022 Annual Questionnaire at the time of data analysis. A total of 2462 participants reported no chronic pain, leaving 2935 participants who reported experiencing chronic pain. The findings from this study highlight that chronic pain is present to a significant degree in sexual and gender minority adults who participated in The PRIDE Study with chronic spine pain being the most common location/region of pain. Notably, more than one-third of non-binary persons, transgender men, and people who selected another gender experienced chronic widespread pain, defined by having 3 or more total regions of chronic pain. The lowest prevalence of chronic widespread pain was among transgender women and cisgender men. When considering sexual orientation, the highest prevalence of widespread pain was in participants who selected another sexual orientation, followed by queer and asexual, demisexual, gray ace, with the lowest prevalence of chronic widespread pain being in those who identify as straight or heterosexual, bisexual, pansexual, gay, and lesbian. Future studies are planned to elucidate how a variety of biopsychosocial mechanisms may influence chronic pain in sexual and gender minority persons.
TCR-H: Machine Learning Prediction of T-cell Receptor Epitope Binding on Unseen Datasets
Authors: T. Rajitha Rajeshwar , Demerdash Omar , Smith Jeremy C. 
Published: November 2023

AbstractAI/ML approaches to predicting T-cell receptor (TCR) epitope specificity achieve high performance metrics on test datasets which include sequences that are also part of the training set but fail to generalize to test sets consisting of epitopes and TCRs that are absent from the training set, i.e., unseen. We present TCR-H, a supervised classification Support Vector Machines model using physicochemical features trained on the largest dataset available to date using only experimentally validated non-binders as negative datapoints. TCR-H exhibits an area under the curve of the receiver-operator characteristic (AUC of ROC) of 0.87 for epitope ‘hard splitting’ (i.e., on test sets with all epitopes unseen), 0.92 for TCR hard splitting and 0.89 for ‘strict splitting’ in which neither the epitopes nor the TCRs in the test set are seen in the training data. TCR-H may thus represent a significant step towards general applicability of epitope:TCR specificity prediction.
Efficacy ofWolbachia-mediated sterility for control of dengue: emulation of a cluster randomized target trial
Authors: Lim Jue Tao , Mailepessov Diyar , Chong Chee Seng , Dickens Borame , Lai Yee Ling , Ng Youming , Deng Lu , Lee Caleb , Tan Li Yun , Chain Grace , Ho Soon Hoe , Chang Chia-Chen , Ma Pei , Bansal Somya , Lee Vernon , Sim Shuzhen , Tan Cheong Huat , Ng Lee Ching 
Published: November 2023

AbstractBackgroundMatings between maleAedes aegyptimosquitoes infected withwAlbB strain ofWolbachiaand wildtype females yield non-viable eggs. We evaluated the efficacy of releasingwAlbB-infectedAe. aegyptimale mosquitoes to suppress dengue.MethodsWe specified the protocol of a two-arm cluster-randomised test-negative controlled trial (cRCT) and emulated it using a nationally representative test-negative/positive database of individuals reporting for febrile illness to any public hospital, general practitioner or polyclinic. We built a cohort of individuals who reside inWolbachialocations versus a comparator control group who do not reside inWolbachialocations. We emulated a constrained randomisation protocol used in cRCTs to balance dengue risk between intervention and control arms in the pre-intervention period. We used the inverse-probability weighting approach to further balance the intervention and control groups using a battery of algorithmically selected sociodemographic, environmental and anthropogenic variables. Intention-to-treat analyses was conducted to estimate the risk reduction of dengue givenWolbachiaexposure.FindingsThe final cohort consisted of 7,049 individuals residing in areas treated byWolbachiainterventions for at least 3 months and 69,216 individuals residing in non-treated areas in the same time period. Intention-to-treat analyses revealed that, compared with controls,Wolbachiareleases for 3, 6, 12 or more months was associated to a 47% (Odds ratio (OR): 0.53 [0.45-0.62]), 47% (OR: 0.53 [0.50-0.65]) and 59% (OR: 0.41 [0.39-0.50]) protective efficacy against dengue respectively. When exposed to 12 or more months ofWolbachiareleases, protective efficacy ranged from 36% (OR: 0.64 [0.58-0.96]) to 77% (OR: 0.23 [0.22-0.33]) dependent on township, and from 48% (OR: 0.52 [0.48-0.7]) to 78% (OR: 0.22 [0.09-0.32]) across years. The proportion of virologically confirmed dengue cases was lower overall in the intervention arm, and across each subgroup. Protective efficacies were found across all townships, years, age and sex subgroups, with higher durations ofWolbachiaexposure similarly associated to greater risk reductions of dengue.InterpretationOur results demonstrated the potential ofWolbachia-mediated sterility for strengthening dengue control in tropical cities, where dengue burden is the greatest.FundingThis study was supported by funding from Singapore’s Ministry of Finance, Ministry of Sustainability and the Environment, National Environment Agency, and National Robotics Program. JTL is supported by the Ministry of Education (MOE), Singapore Start-up Grant. SB is supported by an MOE Tier 2 grant.
Loss ofSlc35a2alters development of the mouse cerebral cortex
Authors: Elziny Soad , Sran Sahibjot , Yoon Hyojung , Corrigan Rachel R. , Page John , Ringland Amanda , Lanier Anna , Lapidus Sara , Foreman James , Heinzen Erin L. , Iffland Philip , Crino Peter B. , Bedrosian Tracy A. 
Published: November 2023

AbstractBrain somatic variants inSLC35A2are associated with clinically drug-resistant epilepsy and developmental brain malformations, including mild malformation of cortical development with oligodendroglial hyperplasia in epilepsy (MOGHE).SLC35A2encodes a uridine diphosphate galactose translocator that is essential for protein glycosylation; however, the neurodevelopmental mechanisms by whichSLC35A2disruption leads to clinical and histopathological features remain unspecified. We hypothesized that focal knockout (KO) or knockdown (KD) ofSlc35a2in the developing mouse cortex would disrupt cerebral cortical development through altered neuronal migration and cause changes in network excitability. We usedin uteroelectroporation (IUE) to introduce CRISPR/Cas9 and targeted guide RNAs or short-hairpin RNAs to achieveSlc35a2KO or KD, respectively, during early corticogenesis. FollowingSlc35a2KO or KD, we observed disrupted radial migration of transfected neurons evidenced by heterotopic cells located in lower cortical layers and in the sub-cortical white matter.Slc35a2KO in neurons did not induce changes in oligodendrocyte number, suggesting that the oligodendroglial hyperplasia observed in MOGHE originates from distinct cell autonomous effects. Spontaneous seizures were not observed, but intracranial EEG recordings after focal KO showed a reduced seizure threshold following pentylenetetrazol injection. These results demonstrate thatSlc35a2KO or KDin vivodisrupts corticogenesis through altered neuronal migration.
Impact of Treatment Adherence and Inhalation Technique on asthma outcomes of Pediatric Patients: A Longitudinal Study
Authors: Lizano-Barrantes Catalina , Garin Olatz , Mayoral Karina , Dima Alexandra L. , Pont Angels , Caballero-Rabasco M. Araceli , Praena-Crespo Manuel , Valdesoiro-Navarrete Laura , Guerra María Teresa , Bercedo-Sanz Alberto , Ferrer Montse 
Published: November 2023

AbstractIntroductionWe aimed to evaluate the longitudinal relationships, both at between- and within-person levels, that adherence to inhaled corticosteroids-based maintenance treatment and inhalation technique present with symptom control, exacerbations, and health-related quality of life (HRQoL) in children and adolescents with asthma.MethodsParticipants (6-14 years old) from the ARCA (Asthma Research in Children and Adolescents) cohort - a prospective, multicenter, observational study (NCT04480242) - were followed for a period from 6 months to 5 years, via computer-assisted telephone interviews and a smartphone application. The Medication Intake Survey–Asthma (MIS-A) was administered to assess the implementation stage of adherence; and the Inhalation Technique Questionnaire (InTeQ) to assess the five key steps when using an inhaler. Symptoms control was measured with the Asthma Control Questionnaire (ACQ), and HRQL with the EQ-5D and the PROMIS-Pediatric Asthma Impact Scale (PROMIS-PAIS). Multilevel longitudinal mixed models were constructed separately with symptom control, exacerbation occurrence, EQ-5D, and PROMIS-PAIS as dependent variables.ResultsOf 360 participants enrolled, 303 (1203 interviews) were included in the symptom control and exacerbation analyses, 265 (732) in the EQ-5D, and 215 (619) in the PROMIS-PAIS. Around 60% of participants were male and most underwent maintenance treatment with inhaled corticosteroids plus long-acting β-agonists in a fixed dose (68–74%). Within-person variability was 83.6% for asthma control, 98.6% for exacerbations, 36.4% for EQ-5D and 49.1% for PROMIS-PAIS. At within-person level, patients with higher adherence had better symptom control (p=0.002) and HRQoL over time (p=0.016). Patients with better inhalation technique reported worse HRQoL simultaneously (p=0.012), but better HRQoL in future assessments (p=0.012). Frequency of reliever use was associated with symptom control (p<0.001), exacerbation occurrence (p<0.001), and HRQoL (p=0.042); and boys were more likely to present better symptom control and HRQoL than girls.ConclusionOur results confirm longitudinal associations at within-person level of the two indicators of quality use of inhalers: for adherence to maintenance treatment with symptom control and HRQoL, and for inhalation technique with HRQoL. Although treatment adherence showed to be excellent, a third part of participants reported a suboptimal inhalation technique, highlighting the need of actions for improving asthma management of pediatric population.
The effect of goal type of user-generated content on consumers' compensatory consumption behavior
Authors: Zhang Hao , Meng Dewen , Lv Xiaolin 
Published: November 2023

PurposeThe purpose of this research is to explore the effect of goal type of user-generated content (UGC) on consumers' intention of within-domain and across-domain compensatory consumption in closed social media platforms, the mediating effect of self-threat, self-enhancement and self-protection motivation and the moderating effect of self-efficacy.Design/methodology/approachFour between-subject experiments were conducted to verify the hypotheses presented in this research. Study 1a had a sample size of 60 respondents and examined the effect of goal type of UGC on compensatory consumption. Study1b replicated the effect by using a sample size of 60 respondents. Study 2 had a sample size of 70 respondents and verified the mediating role of self-threat, self-enhancement motivation and self-protection motivation. Study 3 examined self-efficacy as a critical moderator by using a sample of 255 participants.FindingsStudy 1a and Study 1b demonstrate that UGC with an attainment goal (vs maintenance goal) is more easily produced within-domain and across-domain compensatory consumption. Study 2 verifies that the effect of goal type of UGC on within-domain compensatory consumption is serially mediated by self-threat and self-enhancement motivation, and the effect of goal type of UGC on across-domain compensatory consumption is serially mediated by self-threat and self-protection motivation. Study 3 demonstrates that self-efficacy not only moderates the effects of self-threat on within-domain or across-domain compensatory consumption respectively, but also moderates the whole mediating path structure.Originality/valueThis research extends the understanding of UGC and addresses the inconclusive evidence of the impact of goal type of UGC on consumer compensatory behavior in the context of closed social media platforms. The authors identify the moderating role of self-efficacy, which explains why consumers adopt different compensatory strategies.