bluuebunny/crossref_metadata_2025_split huggingface dataset:
Munkaerő toborzás és megtartás generációs megközelítésben
Authors: Borsos Aranka Viktória 
Published: February 2024

A munkaerőpiac folyamatosan változik; nő a munkavállalók munkában töltött éveinek száma, egyre több generáció képviselteti magát egyidejűleg a munkahelyeken, ugyanakkor a csökkenő népességszámunknak köszönhetően egyre alacsonyabb az újonnan belépők száma, nő az idősebb korosztályok aránya, azonban a globalizáció és a digitális változások hatására a kereslet mégis elsősorban a fiatalabb generációkra irányul, főként az újonnan megjelenő szakmákat érinti, így fokozódik a verseny a munkáltatók közt.
Ahhoz, hogy ebben a versenyhelyzetben a szereplők megfelelően reagálni tudjanak a változásokra, fontos tisztában lenniük azzal, hogy milyen eszközökkel motiválhatók az eltérő generációk.
Ezen téma kapcsán 2023-as kutatásom alkalmával a munkaerő-piacon jelenlévő generációk eltérő munkahelyválasztási szempontjait és a munkahelyi elégedettségüket befolyásoló tényezőit vizsgáltam, hiszen az egyes generációk által támasztott elvárások figyelembevételével könnyebbé és hatékonyabbá válhat a szervezetek emberi erőforrásokkal való gazdálkodása.
Niveles de vitamina D según el estado nutricional de un grupo de niños y adolescentes entre 2015-2019 en Bogotá.
Authors: Ospina Ramírez Claudia Patricia , Cuello y Bertha Calderón Sandra 
Published: February 2024

Introducción: La deficiencia de vitamina D se ha relacionado con alteraciones del estado nutricional. Estudios muestran alta prevalencia en Latinoamérica y en Colombia. Se creía que solo países con poca exposición solar (estacionales) eran propensos a sufrir estas deficiencias, sin embargo, en Bogotá D.C., hay una tendencia a evadir la luz solar (protector solar, ropa abrigada, espacios cerrados), y en conjunto con otras condiciones: sobrepeso, obesidad y estado nutricional deficiente, podrían contribuir a la deficiencia de vitamina D.
Objetivo: Caracterizar los pacientes con insuficiencia y deficiencia de vitamina D en relación con el estado nutricional. Métodos: Estudio descriptivo con 416 pacientes (Edades entre 6 meses a 26 años) con deficiencia de vitamina D, evaluados entre enero de 2015 a julio de 2019 en una consulta privada en la ciudad de Bogotá. Resultados: El 62.5 % tuvieron insuficiencia de vitamina D y 37.5 % deficiencia. 263 pacientes tuvieron estado nutricional normal (63.22 %), seguido de sobrepeso (19.24 %). Sin embargo, de acuerdo con el estado nutricional, la obesidad tuvo mayor deficiencia 58.33 %, desnutrición aguda 57.14 % y sobrepeso 40 %. Para la insuficiencia los más afectados fueron pacientes en riesgo de desnutrición 72.22 %, normales 62.73 % y sobrepeso 60 %. Conclusiones: El 27.6 % de los pacientes, tienen niveles bajos de vitamina D, en su mayoría insuficientes. Los pacientes con déficit tenían un estado nutricional normal.
Genetic Factors Associated with Adverse Pregnancy Outcomes in Chronic Pancreatitis
Authors: Wu Di , Ru Nan , Wang Yuan-Chen , Ma Guo-Xiu , Shi Tian-Yu , Xiong Si-Huai , You Ai-Jun , Wang Lei , Hu Liang-Hao , Li Zhao-Shen , Zou Wen-Bin , Liao Zhuan 
Published: February 2024

OBJECTIVES:
The effects of genetic factors on pregnancy outcomes in chronic pancreatitis (CP) patients remain unclear. We evaluated the impacts of clinical features and mutations in main CP-susceptibility genes (SPINK1, PRSS1, CTRC, CFTR) on pregnancy outcomes in Chinese CP patients.

METHODS:
This was a prospective cohort study with 14-year follow-up. The sample comprised female CP patients with documented pregnancy and known genetic backgrounds. Adverse pregnancy outcomes were compared between patients with and without gene mutations. Univariate and multivariate analyses were performed to determine the impact factors for adverse pregnancy outcomes.

RESULTS:
Totally, 160 female CP patients with a pregnancy history were enrolled; 59.4% of patients carried pathogenic mutations in CP-susceptibility genes. Adverse pregnancy outcomes occurred in 38 patients (23.8%); the prevalence of adverse outcomes was significantly higher in those harboring gene mutations than those without (30.5% vs 13.8%, P = 0.015). Notably, the rates of preterm delivery (12.6% vs 3.1%, P = 0.036) and abortion (17.9% vs 4.6%, P = 0.013) were remarkably higher in patients with gene mutations (especially SPINK1 mutations) than those without. In multivariate analyses, both CP-susceptibility gene mutations (odds ratio [OR], 2.52; P = 0.033) and SPINK1 mutations (OR, 2.60; P = 0.037) significantly increased the risk of adverse pregnancy outcomes. Acute pain attack during pregnancy was another risk factor for adverse pregnancy outcomes.

CONCLUSIONS:
Pathogenic mutations in CP-susceptibility genes, especially SPINK1, were independently related to adverse pregnancy outcomes in CP patients. Significant attention should be paid to pregnant females harboring CP-susceptibility gene mutations. (ClinicalTrials.gov: NCT06055595)
Existence and uniqueness of solution for a singular elliptic differential equation
Authors: Gu Shanshan , Yang Bianxia , Shao Wenrui 
Published: February 2024

Abstract
In this article, we are concerned about the existence, uniqueness, and nonexistence of the positive solution for:

−
Δ
u
−

1

2

(

x
⋅

∇

u

)

=
μ
h

(

x

)

u

q
−
1

+
λ
u
−

u

p

,

x
∈

R

N

,

u

(

x

)

→
0
,

as

∣
x
∣
→
+
∞
,

\left\{\begin{array}{l}-\Delta u-\frac{1}{2}\left(x\cdot \nabla u)=\mu h\left(x){u}^{q-1}+\lambda u-{u}^{p},\hspace{1.0em}x\in {{\mathbb{R}}}^{N},\\ u\left(x)\to 0,\hspace{1em}\hspace{0.1em}\text{as}\hspace{0.1em}\hspace{0.33em}| x| \to +\infty ,\end{array}\right.

where

N
⩾
3

N\geqslant 3

,

0
<
q
<
1

0\lt q\lt 1

,

λ
>
0

\lambda \gt 0

,

p
>
1

p\gt 1

,

μ
>
0

\mu \gt 0

is a parameter and the function

h

(

x

)

h\left(x)

satisfies certain conditions. To start with, based on the variational argument and perturbation method, we obtain the existence and uniqueness of the positive solution for the aforementioned singular elliptic differential equation as

λ
>

N

2

\lambda \gt \frac{N}{2}

. In addition, there is no solution as

λ
⩽

N

2

\lambda \leqslant \frac{N}{2}

. Later, from an experimental point of view, we give the numerical solution of the aforementioned singular elliptic differential equation by means of a neural network in some special cases, which enrich the theoretical results. Our conclusions partially extend the results corresponding to the nonsingular case.
N-linked glycosylation of the M-protein variable region: glycoproteogenomics reveals a new layer of personalized complexity in multiple myeloma
Authors: Langerhorst Pieter , Baerenfaenger Melissa , Kulkarni Purva , Nadal Simon , Wijnands Charissa , Post Merel A. , Noori Somayya , vanDuijn Martijn M. , Joosten Irma , Dejoie Thomas , van Gool Alain J. , Gloerich Jolein , Lefeber Dirk J. , Wessels Hans J.C.T. , Jacobs Joannes F.M. 
Published: February 2024

Abstract

Objectives
Multiple myeloma (MM) is a plasma cell malignancy characterized by a monoclonal expansion of plasma cells that secrete a characteristic M-protein. This M-protein is crucial for diagnosis and monitoring of MM in the blood of patients. Recent evidence has emerged suggesting that N-glycosylation of the M-protein variable (Fab) region contributes to M-protein pathogenicity, and that it is a risk factor for disease progression of plasma cell disorders. Current methodologies lack the specificity to provide a site-specific glycoprofile of the Fab regions of M-proteins. Here, we introduce a novel glycoproteogenomics method that allows detailed M-protein glycoprofiling by integrating patient specific Fab region sequences (genomics) with glycoprofiling by glycoproteomics.

Methods
Glycoproteogenomics was used for the detailed analysis of de novo N-glycosylation sites of M-proteins. First, Genomic analysis of the M-protein variable region was used to identify de novo N-glycosylation sites. Subsequently glycopeptide analysis with LC-MS/MS was used for detailed analysis of the M-protein glycan sites.

Results
Genomic analysis uncovered a more than two-fold increase in the Fab Light Chain N-glycosylation of M-proteins of patients with Multiple Myeloma compared to Fab Light Chain N-glycosylation of polyclonal antibodies from healthy individuals. Subsequent glycoproteogenomics analysis of 41 patients enrolled in the IFM 2009 clinical trial revealed that the majority of the Fab N-glycosylation sites were fully occupied with complex type glycans, distinguishable from Fc region glycans due to high levels of sialylation, fucosylation and bisecting structures.

Conclusions
Together, glycoproteogenomics is a powerful tool to study de novo Fab N-glycosylation in plasma cell dyscrasias.
Identification of the tip mass parameters in a beam-tip mass system using response surface methodology
Authors: Gökdağ Hakan , Doğanay Katı Hilal 
Published: February 2024

Abstract
In this study, a response surface based approach is introduced to determine the physical parameters of the tip mass of a beam – tip mass system, such as mass, mass moment of inertia and coordinates of the centre of gravity with respect to the beam end point. To this end, first, a difference function was formulated based on the differences between the peak frequencies and peak amplitudes of the experimental and analytical frequency response functions. Later, observation points were established in the design space using orthogonal arrays, and a response surface was developed using the difference function values at these points. Next, the tip mass parameters were determined by minimizing the response surface with genetic algorithm and particle swarm optimization as well as fmincon, a gradient-based solver of the Matlab program. For comparison purposes, those parameters were obtained by also direct minimization of the difference function with the same algorithms. It was concluded that the tip mass parameters were successfully determined within reasonable error limits by the response surface method with less computational burden. Finally, the effect of design space width on the response surface quality is demonstrated numerically.
Mechanical damage mechanism investigation on CFRP strengthened recycled red brick concrete
Authors: Ji Yongcheng , Li Zheng , Xu Wenyuan , Li Wei 
Published: February 2024

Abstract
Three reinforcement ratios (0, 50, and 100%) of carbon fiber reinforced plastics (CFRP) were selected to improve the mechanical properties of recycled brick concrete in this study. Utilizing axial compression test, X-ray diffractometer analysis, the evolution of parameters such as compressive strength, peak stress, and elastic modulus of reclaimed concrete were analyzed. The reclaimed brick concrete’ stress distribution and damage mechanism were revealed. The aggregate internal failure and CFRP reinforcement effect mechanism are discussed. The finite element model of red brick concrete reinforced by CFRP under uniaxial compression is established. The constitutive model for CFRP-reinforced recycled brick concrete is proposed.
Infrastructure and Gender Disparity in Information Communication Technology Literacy: A Cross-Country Comparative Study
Authors: Liu Suyu 
Published: February 2024

Abstract
Information Communication Technology (ICT) literacy is essential in the digital age, and an important channel to acquire essential ICT skills is science education. Gender gap in ICT literacy and the associated reasons remain under-explored, especially at macro level. Using country level data from the database of Sustainable Development Goals (SDGs), this article explores the association between infrastructure and gender disparity in ICT literacy, both have direct relationship with science education. SDG Indicator 4.5.1 monitors the female/male ratio of acquiring the ability to use basic arithmetic formula in a spreadsheet (ARSP) at country level, which is selected into this article to measure gender disparity in ICT literacy. SDG Indicator 9.c.1 (the population coverage of 4G mobile network) is used to measure infrastructure development. SDG Indicator 4.4.1, monitors the percentage of population with ARSP skills, which also demonstrates the level of science education, is controlled as an independent variable. Linear regressions and correlations were conducted to explore the relationship between infrastructure and gender gap in ICT literacy in 30 countries, and Mann-Whitney U test was performed to conduce comparisons between high income and middle/low income countries. Infrastructure contributes to reduce gender gap in ICT literacy, because infrastructure can improve a country’s science education which can benefit both men and women’s ICT skills. However such influence may vary across countries. Reasons of the results were discussed with implications for policies.
Handgrip Strength Is Not Associated With High Blood Pressure and Does Not Have Good Discriminatory Power for High Blood Pressure in Adolescents
Authors: de Lima Tiago Rodrigues , Silva Diego Augusto Santos 
Published: February 2024

Abstract
de Lima, TR and Silva, DAS. Handgrip strength is not associated with high blood pressure and does not have good discriminatory power for high blood pressure in adolescents. J Strength Cond Res 37(1): 46–54, 2023—Muscle strength measured by handgrip strength (HGS) was inversely and independently associated with high blood pressure (HBP). In addition, HGS has been used as a valuable indicator for monitoring pediatric health. This study aimed to investigate the association between HGS indexes and HBP, verify the discriminatory capacity of HGS to identify HBP in adolescents, and propose cut-points for HGS to be used in the early identification of HBP if good discriminatory power is identified between the variables. This was a cross-sectional study comprising 811 adolescents (male: 48.9%; age: 16.4 ± 1.3 years) from southern Brazil. Blood pressure was measured by the oscillometric method. Handgrip strength was assessed by a hand dynamometer and 3 different approaches were adopted: (a) HGS in kilogram-force, (b) normalized HGS (HGS/body mass), and (c) allometric HGS (HGS/body mass−0.67). Binary logistic regression was used to verify the association between HGS indexes and HBP, and the receiver operating characteristic (ROC) was used to determine the possible use of HGS as a diagnostic tool for HBP. Handgrip strength indexes were not associated with HBP (p > 0.05), and ROC analyses showed a nonsignificant discriminating accuracy for most of the HGS indexes analyzed (p > 0.05) in identifying HBP in boys and girls. The area under curve (AUC) values ranged from 0.499 (95% CI [0.403–0.596] for allometric HGS among overweight or obese boys) to 0.595 (95% CI [0.546–0.643] for HGS among boys). Handgrip strength was not associated with HBP, and its use in the screening of HBP in adolescents is not recommended.
Remdesivir for COVID-19 in Hospitalized Children: A Phase 2/3 Study
Authors: Ahmed Amina , Munoz Flor M. , Muller William J. , Agwu Allison , Kimberlin David W. , Galli Luisa , Deville Jaime G. , Sue Paul K. , Mendez-Echevarria Ana , Humeniuk Rita , Guo Susan , Rodriguez Lauren , Han Dong , Hedskog Charlotte , Maxwell Heather , Palaparthy Ramesh , Kersey Kathryn , Rojo Pablo ,   CARAVAN Study Investigators
Published: February 2024

OBJECTIVES
Remdesivir decreases the risk of SARS-CoV-2 infection progressing to severe disease in adults. This study evaluated remdesivir safety and pharmacokinetics in infants and children.

METHODS
This was a phase 2/3, open-label trial in children aged 28 days to 17 years hospitalized for polymerase chain reaction–confirmed SARS-CoV-2 infection. Participants received for ≤10 days once-daily intravenous remdesivir doses defined using physiologically based pharmacokinetic modeling (for ≥40 kg, 200 mg day 1, then 100 mg/day; for age ≥28 days and ≥3 to &lt;40 kg, 5 mg/kg day 1, then 2.5 mg/kg/day). Sparse pharmacokinetic samples were analyzed using population–pharmacokinetic approaches for remdesivir and metabolites GS-704277 and GS-441524.

RESULTS
Among 53 participants, at enrollment the median (Q1, Q3) number of days of COVID-19 symptoms was 5 (3, 7) and hospitalization was 1 (1, 3). Underlying conditions included obesity in 19 (37%), asthma in 11 (21%), and cardiac disorders in 11 (21%). Median duration of remdesivir treatment was 5 days (range, 1–10). Remdesivir treatment had no new apparent safety trends. Two participants discontinued treatment because of adverse events including elevated transaminases; both had elevated transaminases at baseline. Three deaths occurred during treatment (and 1 after). When compared with phase 3 adult data, estimated mean pediatric parameters (area under the concentration-time curve over 1 dosing interval, AUCτ, Cmax, and Cτ) were largely overlapping but modestly increased (remdesivir, 33%–129%; GS-704277, 37%–124%; GS-441524, 0%–60%). Recovery occurred for 62% of participants on day 10 and 83% at last assessment.

CONCLUSIONS
In infants and children with COVID-19, the doses of remdesivir evaluated provided drug exposure similar to adult dosing. In this study with a small sample size, no new safety concerns were observed.
Gut microbiota at different stages of cardiovascular disease continuum
Authors: Yafarova A. A. , Dementyeva E. D. , Zlobovskaya O. A. , Kiselev A. R. , Sheptulina A. F. , Ashniev G. A. , Zhamalov L. M. , Makarov V. V. , Yudin S. M. , Drapkina O. M. 
Published: February 2024

Aim. To study the relationship of gut microbiota (GM) composition with clinical and paraclinical characteristics of patients with coronary artery disease (CAD) and heart failure with reduced ejection fraction (HFrEF).Material and methods. The study included 64 patients (men, 71,9%) with CAD, 33 (men, 87,9%) with HFrEF and 38 (men, 63,2%) with various cardiovascular risk factors (control group). GM composition was assessed using real-time polymerase chain reaction and next- generation sequencing. To identify correlations of GM composition with clinical and paraclinical characteristics, the Spearman rank correlation coefficient (ρ) was calculated. Generalized linear models (QuasiPoisson, overdispersion) with covariates (age, body mass index) were used to compare groups by phylotype.Results. The relative abundance of Bacillota phylotypes is significantly higher in patients with CAD and HFrEF compared to controls (p<0,001). The Bacillota/Bacteroidota dysbiosis ratio was also significantly higher in patients with CAD and HFrEF than in the control group (p<0,001). According to correlation analysis, the relative representation of methanogenic archaea Methanomassiliicoccaceae, Methanomethylophilaceae (ρ=0,49, p<0,0003) directly correlated with ventricular arrhythmias in patients with HFrEF.Conclusion. Patients with CAD and HFrEF differ significantly from the control group in GM composition at the phylotype level. In the study groups, Bacillota/Bacteroidota dysbiosis ratio was also significantly higher than in the control group. The relative abundance of the archaea Methanomassiliicoccaceae and Methanomethylophilaceae is associated with episodes of ventricular tachycardia/ventricular fibrillation.
Validation of genetic risk scores for hypertension in the Central Russian population
Authors: Limonova A. S. , Ershova A. I. , Kiseleva A. V. , Kutsenko V. A. , Ramensky V. E. , Vyatkin Yu. V. , Sotnikova E. A. , Zharikova A. A. , Zaichenoka M. , Pokrovskaya M. S. , Shalnova S. А. , Meshkov A. N. , Drapkina O. M. 
Published: February 2024

Aim. To validate and evaluate the accuracy of 4 genetic risk scores (GRSs) for hypertension (HTN), previously created on European samples, on a population sample of the Ivanovo Oblast.Material and methods. For genetic analysis, targeted next-generation sequencing was used on a sample of the Central Russia (n=1682) based on the biobank collection. Four GRSs associated with HTN, previously developed for the European population, were selected for validation. The coefficient of determination and the area under the ROC curve were used as quality metrics for regression models. Additional validation was carried out to include all nucleotide sequence variants, regardless of linkage disequilibrium level. A combined GRS was compiled based on coefficients from individual GRSs using the clumping + thresholding (C+T) method.Results. The study demonstrated that the predictive value of previously developed GRSs when used for Central Russian population is lower than in the original studies. The proportion of explained variance was 0,5-0,8%. The best predictive ability (proportion of explained variance — 2,5%) was demonstrated using previously developed GRSs (Evangelou E, et al., 2018), which includes the largest number of nucleotide sequence variants (n=852).Conclusion. GRSs for HTN, developed on European samples, is not recommended for Russian population without preliminary validation. To create original GRSs, combining statistical parameters (β-coefficients and p-value) from different GRS is not recommended.
Influence of multimorbidity on the risk of events in men with chronic coronary artery disease after myocardial infarction and percutaneous coronary intervention
Authors: Dedov D. V. , Mazaev V. P. , Kovalchuk A. N. , Komkov A. A. , Ryazanova S. V. 
Published: February 2024

Aim. To study the effect of multimorbidity on the risk of cardiovascular events (CVEs) in men with chronic coronary artery disease (CAD) after myocardial infarction (MI) and percutaneous coronary intervention (PCI).Material and methods. A total of 101 men with chronic CAD after MI and PCI were included in the study (mean age 60,5±6,1 years). Of these, taking into account the non-inclusion criteria and consent to examination, 2 following groups were formed: first (n=39) — men without CVEs; 2nd (n=39) — men with CVEs. In both groups, we studied the detection rate of grade I hypertension (HTN), class I obesity, hypercholesterolemia (HCE), and type 2 diabetes (T2D). The influence of HTN, obesity, HCE, and T2D on the risk of cardiovascular events was analyzed based on the calculation of contingency tables and Pearson's χ2, as well as odds ratios (OR) with 95,0% confidence intervals (CI). The follow-up period for patients averaged 3,6±0,5 years.Results. In men of group 2, compared with group 1 patients, grade I HTN, class I obesity, HCE were diagnosed more often in 1,3 (p=0,044), 1,4 (p=0,047), 1,2 (p=0,059) times, respectively. An increase in the risk of CVEs in men with chronic CAD, who underwent MI and PCI was associated with the detection of grade I HTN, class I obesity, HCE — OR 2,44 (CI: 1,88-6,75), OR 1,78 (CI: 1,56-4,62), OR 1,37 (CI: 1,11-4,17), respectively.Conclusion. Thus, the detection rate of grade I HTN, class I obesity and HCE in men with chronic CAD and CVEs at long-term follow-up after MI and PCI was significantly higher compared to patients with chronic CAD without CVEs after PCI. At the same time, the detection of grade I HTN, class I obesity and HCE were associated with an increased risk of cardiovascular events.