bluuebunny/crossref_metadata_2025_split huggingface dataset:
Phenotypic characterization and genetic diversity of macauba (Acrocomia aculeata) accessions based on oil attributes and fruit biometrics
Authors: Madeira Débora Durso Caetano , Motoike Sérgio Yoshimitsu , Simiqueli Guilherme Ferreira , Kuki Kacilda Naomi , Goulart Samuel Melo , Rigolon Thaís Caroline Buttow , Nogueira Pedro Tiago Santos , Castro Amanda Silva , Couto Evellyn Giselly Oliveira 
Published: October 2023

Abstract
Macauba is a Brazilian native palm widely distribute in environments with different edaphoclimatic characteristics. Its fruits have a great economic potential because the presence of oil in the pulp and kernel, that can be used in the biofuel, cosmetic and food companies. Macauba is a non-domesticated specie, and their genetic variability is an important characteristic to be evaluate, aiming the selection of superior genotypes to start a pre-breeding of the palm. In this context, the objective of this work was evaluating the genetic variability in macauba genotypes from different Brazilian locations. For this, 50 accessions were evaluated for following phenotypic trait: oil attributes and fruit biometry. The genotypes distributed in the accessions, were divided into three populations according to the state of origin: Pop1 was formed with accessions from Mato Grosso do Sul and São Paulo, Pop2 from Pará and Pernambuco, and Pop3 from Minas Gerais. The pulp oil was extracted to obtain the oil attributes: pulp oil content, fatty acid composition, carotenoid content, and pulp oil color. Fruit biometrics were performed to obtain total fruit weight and dry mass of husk, pulp, endosperm and kernel. Results showed that Pop1 presented the smallest fruits and the highest content of carotenoids, while Pop2 and Pop3 presented the largest fruits and lower carotenoid content. The highest oil content was observed in Pop3. Genetic diversity showed that genotypes clustered according to their geographic origin. Our results reveal that macauba had high variability for the traits evaluated and potential to be genetic improved.
Clinicopathological features of breast cancer progression: From DCIS to invasive ductal carcinoma
Authors: Zhang Jiahang , Aishan Nardire , SAAD BISSESSUR ABDUL , Chen Yongxia , Zhou Jichun , Ji Feiyang , Wang Linbo 
Published: October 2023

Abstract
Purpose
Ductal carcinoma in situ (DCIS) is regarded as non-invasive precursor lesion of invasive ductal carcinoma (IDC) but the molecular mechanisms and tumorigenesis behind DCIS progression remain to be elucidated. IDC sometimes present with a synchronous in-situ component (IDC-DCIS). The current study investigated the clinicopathological features that could predict DCIS progression and trace the origin of IDC.
Methods
Total 501 breast ductal carcinoma patients who underwent surgery as a first-line treatment between 2019 to 2022 from Sir Run Run Shaw Hospital were retrospectively reviewed. The clinical outcomes in different molecular subtypes and nuclear grade were evaluated.
Results
DCIS was significantly associated with a positive CK5/6 expression (P < 0.001), which was observed especially in HER2 overexpression subtype (P = 0.0027). Compared to IDC-DCIS, EGFR expression was significantly higher in IDC (P < 0.001) in triple-negative subtype (P < 0.001). In IDC-DCIS, co-expression of several biomarkers was observed in the DCIS component and IDC component. High grade DCIS component was significantly associated with HER2 and high Ki-67 (P < 0.001). Compared to pure DCIS, the in-situ component of IDC-DCIS was associated with high Ki-67 (P = 0.004), negative EGFR (P = 0.003), positive CK5/6 (P < 0.001) and high grade (P = 0.004).
Conclusion
Molecular subtypes, nuclear grade, and expressions of EGFR and CK5/6 resulted in different clinicopathological profiles in DCIS, IDC-DCIS and IDC. Presence of in-situ component is a marker of reduced aggressiveness and also supported that DCIS is the precursor lesion. Overall, our study traced the origin of IDC and propounded that HER2 targeted therapies could be of potential use in DCIS clinical trials.
IIPLE: Integrated Interactive Programming Lab Environment
Authors: Isuru Hettiarachcchige H.I.A , Zulficar M.Z.M Zaqwan Zaqwan , De Silva Silva S.K.S Sandeepa , Dilshan Dilshan De Silva , Vidanarachchi Samitha Vidanarachchi Samitha 
Published: October 2023

Abstract
This paper presents an interactive educational programming environment designed to offer real-time assistance, specifically tailored for novice programmers encountering coding challenges. Many programmers, when embarking on their coding journey encounter difficulties in grasping fundamental programming concepts, resulting in coding errors. Recovering from such situations often necessitates experienced guidance to understand the root causes of these challenges. However, seeking personalized guidance can be time-consuming or even infeasible due to resource constraints. This paper introduces a solution developed to address these issues, providing a platform for programmers to seek real-time guidance and assistance through an AI-powered chatbot.
Investigation of menstrual disorders in systemic lupus erythematosus Patients
Authors: Nirouei Hadieh , Fatemi Alireza , Abdolahi Nafiseh , Aghaei Mehrdad , Azaderah Mahboubeh , Yazdooei Yasmin 
Published: October 2023

Abstract
Background
Persistent menstrual disorders are relatively common in patients with SLE, including hypermenorrhea, oligomenorrhea, amenorrhea, and temporary persistent amenorrhea. These failures are due to autoimmunity and medications, especially immunosuppressive agents.
Materials and methods
This cross-sectional pilot study was performed on all the SLE patients referred to our medical department who were eligible for participation. Venous blood samples were taken for FSH, LH, and anti-mullerian hormone measurement.
Results
50 patients divided into two groups, 16–35 (46%) and 51 − 35 (54%), were included in the study. Among the patients, 82% used hydroxychloroquine, 80% prednisolone, 20% Azathioprine and 6% methotrexate. Dysmenorrhea was more common in the age group of 51 − 35 years, but there was no statistically significant difference between the two groups. The frequency of the people using prednisolone was remarkably more than non-users (94.7% vs. 5.3%), with a significant relationship between the two groups; However, there was no significant difference between patients with polymenorrhagia and menorrhagia. Additionally, menstrual disorders were not significant in patients who received hydroxychloroquine and azathioprine and those who received no medications. Furthermore, the frequency distribution of the mentioned menstrual disorders was investigated according to the SLEDAI index. The average FSH, LH, and anti-mullerian hormone values had no statistical difference between the mild, moderate, and severe flare groups.
Conclusion
In conclusion, menstrual cycle disorders with dysmenorrhea dominant are probably related to the drugs used, especially prednisolone, by patients with SLE.
Unraveling the surface marker signature of cell-derived vesicles via proteome analysis and nanoparticle flow cytometry
Authors: Lau Hui-Chong , Passalacqua Ilaria , Jung Jik-Han , Kwon Yerim , Zocco Davide , Park Sung-Soo , Oh Seung Wook 
Published: October 2023

Abstract
The cell-derived vesicles (CDVs) obtained using a proprietary extrusion process are the foundation of BioDrone™ platform technology. With superior productivity and versatility, this technology has garnered increasing attention in broad applications, particularly as a drug delivery vehicle. Previously, we showed that CDVs exhibited varying levels of expression for tetraspanin and organelle membrane markers while revealing no discernible differences in physical characteristics compared to naturally produced extracellular vesicles (EVs). To further understand and utilize the therapeutic potentials of CDVs, a more comprehensive study of membrane protein profiles is necessary. In addition, it is crucial to validate that the CDVs produced from extrusion are indeed intact lipid vesicles rather than other impurities. Here, we produced multiple batches of CDVs and EVs from HEK293 cells. CDVs and EVs were subjected to the same purification processes for subsequent proteome and particle analyses. The proteome analyses revealed unique proteome signatures between CDVs, EVs, and parental cells. Extensive proteome analyses identified the nine most prominent membrane markers that are abundant in CDVs compared to cells and EVs. Subsequent western blotting and nanoparticle flow cytometry analyses confirmed that CD63, lysosome-associated membrane glycoprotein 1 (LAMP1), and nicastrin (NCSTN) are highly enriched in CDVs, whereas CD81, CD9, and prostaglandin F2 receptor negative regulator (PTGFRN) are more abundant in EVs. This highlights the unique membrane composition and marker signature of CDVs that are distinct from EVs. Lastly, we demonstrated that more than 90% of the CDVs are genuine lipid vesicles by combining two different classes of vesicle labeling dyes and detergents to disrupt lipid membranes. This indicates that our proprietary extrusion technology is highly compatible with other well-characterized EV production methods. The robust CDV markers identified in this study will also facilitate the engineering of CDVs to achieve enhanced therapeutic effects or tissue-selective cargo delivery.
Investigation of the rheological alterations in Iota carrageenan through the exchange of potassium with calcium ions.
Authors: Khailkhura Shashank , Bhatt Akanksha , purohit Priyank 
Published: October 2023

Abstract
Carrageenan is a natural polymer extracted from the Red-Seaweeds that is important for the food and pharmaceutical industries. It is crucial to comprehend how the ion exchange affects the rheological properties of Iota carrageenan polymer, particular potential for gelation, which has several applications in the food and pharmaceutical industries. The current study focuses on analyzing the rheological changes brought on by the exchange of potassium ions with calcium ions in Iota carrageenan. Due to their distinct associations with the anion component, monovalent and divalent cations both have a varied impact on the gelation property of carrageenan.
UAV-based approach for municipal solid waste landfill monitoring and water ponding issue detection using sensor fusion
Authors: Hassan Syed Zohaib , Sun Peng , Gokgoz Mert , Chen Jiannan , Reinhart Debra R. , Gustitus-Graham Sarah 
Published: October 2023

Abstract

Municipal solid waste (MSW) landfills need regular monitoring to ensure proper operations and meet environmental protection requirements. One requirement is to monitor landfill gas emissions from the landfill cover while another requirement is to monitor the potential settlement and damage to MSW landfill covers. Current surveying methods on a landfill cover are time- and labor-intensive and have limited spatial coverage. Landfill operators and researchers have developed unmanned aerial vehicle (UAV)-based monitoring over recent years; however, UAV-based automatic detection of water ponding in landfills has not been studied. Hence, this study proposes a UAV-based approach to monitor landfills and detect water ponding issues on covers by using multimodal sensor fusion. Data acquired from sensors mounted on a UAV were combined, leading to the creation of a ponding index (PI). This index was used to detect potential ponding sites or areas of topographical depression. The proposed approach has been applied in a case study of a closed MSW landfill before and after Hurricane Ian. A comparison between the generated PI map and a manual survey revealed a satisfactory performance with an IoU score of 70.74%. Hence, the utilization of UAV-based data fusing and the developed PI offers efficient identification of potential ponding areas.
UV/periodate and UV/chlorine for dye degradation and real wastewater treatment: a comparative study
Authors: Madihi-Bidgoli Soheila , Asghari Fatemeh , Cheraghi Sahel , Hamidinia Hadis , Shagerdi Elnaz , Asadnezhad Sahar 
Published: October 2023

Abstract
The discharge of synthetic dyes into the environment poses a significant threat to both human health and the ecosystem, necessitating the treatment of contaminated water. To generate free radicals for the elimination of Direct Blue 71 (DB71) dye from aqueous solutions, periodate (PI) and chlorine (Cl2) have been employed. In this study, separate activation of PI and Cl2 was achieved using ultraviolet (UV) light. The impact of various operational parameters was investigated, resulting in the complete degradation of the dye within 12 min. The presence of ferrous and copper ions had a minor enhancing effect on the degradation rate in both systems. Scavenging experiments confirmed that HO• and IO3• were the primary agents responsible for DB71 degradation in the UV/PI system, while reactive chlorine radicals played a dominant role in the UV/Cl2 process. In terms of mineralization, application for real wastewater and energy efficiency, the UV/PI system exhibited slightly superior performance compared to the UV/Cl2 system.
Evaluation of in vitro Antioxidant and Hypoglycemic Activities of Methanol
Extract of Root of Cryptolepis buchanani in Streptozotocin-induced Diabetic
Rats
Authors: Ojha Smriti , Ajeet  , Gupta Saurabh Kumar , Mishra Sudhanshu 
Published: October 2023

Background:
The present research aimed to assess the relationship between free radical
scavenging activity and oral hypoglycemic potential of methanol extract of the root of Cryptolepis
buchanani in Albino Wistar rats.

Objective:
The following research aimed to study and evaluate the antidiabetic efficacy of the natural
plant extracts Cryptolepis buchanani.

Methods:
Phytochemical screening was done to analyze, and in vitro, the antioxidant activity of
plant root extract has been evaluated using DPPH assay and Fe+3 Reducing Power Assay. Streptozotocin
at a 60 mg/kg dose was used to induce diabetes in albino Wistar rats, which was then treated
with methanol extracts (125 and 250 mg/kg, PO) to evaluate antidiabetic activity.

Results:
The results indicated that methanol extract of the root of Cryptolepis Buchanan had shown
its promising antidiabetic potential at a dose of 250 mg/kg in experimental diabetic Wistar rats,
which may be linked to its antioxidant property.

Conclusion:
This experimental study revealed that the extract could potentially alleviate the augmented
oxidative state correlated with diabetes. The marked reduction in blood glucose levels
proves the hypoglycemic activity of the plant.
Pemodelan produk Variable Annuity di industri asuransi jiwa
Authors: Wicaksono Agung 
Published: October 2023

Secara umum, bisnis asuransi jiwa terbagi menjadi 3 lini bisnis yaitu asuransi jiwa, asuransi kesehatan, dan anuitas. Adapun yang akan dibahas lebih lanjut pada makalah ini adalah anuitas. Dilihat dari tingkat hasil investasinya anuitas dapat dibagi menjadi dua yaitu Certain Annuity (Anuitas Pasti) dan Variable Annuity (Anuitas Variabel). Menurut Kellison (2009:73), anuitas merupakan rangkaian pembayaran secara berkala dalam waktu tertentu, misalnya tahunan atau bulanan. Selain itu, anuitas juga bisa disebut sebagai program asuransi jiwa yang bertujuan memberikan kepastian adanya kesinambungan pendapatan bagi tertanggung/peserta ketika menjalani masa purna bhakti beserta keluarganya apabila tertanggung/peserta meninggal dunia. Besar manfaatnya umumnya sebesar nominal tertentu atau dihitung berdasarkan alokasi premi sekaligus, dan manfaatnya dibayarkan secara berkala.Pada makalah ini akan dibahas mengenai variable annuity. Menurut Runhuan Feng (2012:3), variable annuity merupakan anuitas yang menawarkan profit sharing dari dana investasi. Biaya-biaya yang timbul pada variable annuity tergantung pada subaccount pilihan pemegang polis. Setiap subaccount diinvestasikan dalam metode tertentu dengan tujuan investasi yang berbeda. Untuk melindungi investor dari risiko kerugian, perusahaan asuransi juga menjual produk yang bergaransi, yaitu Guaranteed Minimum Maturity Beneﬁt (GMMB), Guaranteed Minimum Death Beneﬁt (GMDB), dan Guaranteed Minimum Accumulation Beneﬁt (GMAB).Produk variable annuity diharapkan menjawab kebutuhan dari konsumen akan adanya kesinambungan penghasilan saat memasuki usia pensiun. Selain itu variable annuity juga diharapkan menjawab keresahan dari perusahaan asuransi jiwa akan besarnya risiko produk Certain Annuity.
Penerapan Analisis Faktor Terhadap Efektivitas Pembelajaran Online Mahasiswa FMIPA UNY Selama Pandemi Covid-19
Authors: Fitri Anisa Al , Hasnida Irena Sekar Dwi , Supartini Endang 
Published: October 2023

Masuknya wabah Covid-19 berdampak pada kehidupan masyarakat, mulai
dari bidang ekonomi melemah, kegiatan yang melibatkan banyak orang dibatasi, dan
juga pendidikan mulai terganggu. Semua aktivitas pendikan baik di sekolah maupun di
kampus dilakukan secara daring untuk menghindari risiko tertularnya virus Covid-19.
Adanya perubahan pada sistem pembelajaran ini tentunya akan memberikan beberapa
kendala, mulai dari peralihan konsep belajar sampai media belajar yang dibutuhkan.
Penelitian ini dilakukan untuk mengetahui faktor-faktor yang mempengaruhi
efektivitas pengajaran dan pembelajaran online selama pandemi Covid-19 menurut
persepsi mahasiswa Fakultas Matematika dan Ilmu Pengetahuan Alam Universitas
Negeri Yogyakarta (FMIPA UNY). Metode yang digunakan pada penelitian ini adalah
analisis faktor. Data yang digunakan merupakan data primer dari kuesioner yang
dilakukan secara daring melalui google formulir yang berisi pertanyaan terbuka dan
tertutup. Dari hasil analisis menggunakan analisis faktor, diperoleh lima faktor yang
terbentuk, yaitu : kelebihan dan kekurangan kuliah online, sarana prasarana dan
mekanisme perkuliahan online, komunikasi selama perkuliahan online, pengalaman
dan fleksibilitas selama perkuliahan online, dan keaktifan di kelas selama perkuliahan
online.
Within-Person Associations of Accelerometer-Assessed Physical Activity With Time-Varying Determinants in Older Adults: Time-Based Ecological Momentary Assessment Study
Authors: Maes Iris , Mertens Lieze , Poppe Louise , Vetrovsky Tomas , Crombez Geert , De Backere Femke , Brondeel Ruben , Van Dyck Delfien 
Published: October 2023

Background
Despite the availability of physical activity (PA) interventions, many older adults are still not active enough. This might be partially explained by the often-limited effects of PA interventions. In general, health behavior change interventions often do not focus on contextual and time-varying determinants, which may limit their effectiveness. However, before the dynamic tailoring of interventions can be developed, one should know which time-dependent determinants are associated with PA and how strong these associations are.

Objective
The aim of this study was to examine within-person associations between multiple determinants of the capability, opportunity, motivation, and behavior framework assessed using Ecological Momentary Assessment (EMA) and accelerometer-assessed light PA, moderate to vigorous PA, and total PA performed at 15, 30, 60, and 120 minutes after the EMA trigger.

Methods
Observational data were collected from 64 healthy older adults (36/64, 56% men; mean age 72.1, SD 5.6 y). Participants were asked to answer a time-based EMA questionnaire 6 times per day that assessed emotions (ie, relaxation, satisfaction, irritation, and feeling down), the physical complaint fatigue, intention, intention, and self-efficacy. An Axivity AX3 was wrist worn to capture the participants’ PA. Multilevel regression analyses in R were performed to examine these within-person associations.

Results
Irritation, feeling down, intention, and self-efficacy were positively associated with subsequent light PA or moderate to vigorous PA at 15, 30, 60, or 120 minutes after the trigger, whereas relaxation, satisfaction, and fatigue were negatively associated.

Conclusions
Multiple associations were observed in this study. This knowledge in combination with the time dependency of the determinants is valuable information for future interventions so that suggestions to be active can be provided when the older adult is most receptive.
Trends in the development of the labor market of young professionals with higher education
Authors: Tarasyeva T. V. 
Published: October 2023

The discrepancy between the level of qualifications and competencies of specialists produced by universities and the demand of the labor market has become the main challenge for the competitiveness and development of universities at the beginning of the XXI century. However, in recent years, the higher education sector has been characterized by the desire of universities to solve this problem by reducing the imbalance between the graduation of specialists and the needs of potential employers. In this connection, a new strategy for the development of universities aimed at shaping the content and structure of the educational process in accordance with the requirements of the labor market and the specifics of technology development at the present stage of higher education development is becoming a key factor for ensuring a sustainable pace of university development. The purpose of the study is to compare the state of the labor market in general and the labor market of young professionals with higher education for the period 2010–2021. to identify their relationship with the features of the modern strategic development of universities and to check the impact of the graduation structure in the areas of training and the relevance of the acquired competencies on the development of the labor market in the short term. The article offers a set of indicators that allows a comprehensive assessment of the situation in the labor market segment – the labor market of young professionals with higher education. The possibility of considering the functioning of the labor market in connection with the peculiarities of modern university development significantly expands the understanding of the labor behavior of university graduates and can also be the basis for adjusting the strategic development of universities in terms of the structure of the graduation of young specialists, which together can serve as a factor in increasing the competitiveness of universities in the educational services market.
Agricultural technology adoption for smallholder small grain farmers in Zimbabwe. Implications for food system transformation and sustainability
Authors: Dube-Takaza Tryphina , Maumbe Blessing M , Parwada Cosmas 
Published: October 2023

Abstract
Food security is a perennial concern in natural regions IV and V of Zimbabwe, that receive low rainfall per annum. Improved small grain varieties and conservation agriculture practices provide a promise for bumper harvests in these dry regions. This study focused on four districts (Binga, Chiredzi, Hwange and Matobo) from these two regions to determine patterns for improved small grain varieties and conservation agriculture technology adoption by smallholder small grain farmers. Data were collected from 281 respondents using structured questionnaires and interviews. The statistical package Stata (version 16) was used to analyse data. Logit and multinomial models were used to compare non-adopters and adopters of technologies in order to show the rationale for adoption. Results indicated that 56% of the sample were non-adopters while 44% were adopters. Adoption patterns varied with location, education, land size, marital status, frequency of extension visits and access to credit. The study recommends increased funding to research institutions that develop high-yield small grain varieties. Comparative studies are recommended in other semi-arid regions of Zimbabwe to support the study findings in informing future policy.