bluuebunny/crossref_metadata_2025_split huggingface dataset:
Results of streamlining TAVR procedure towards a minimalist approach: a single center experience in Taiwan
Authors: Ko Tsung-Yu , Kao Hsien-Li , Chen Yi-Chang , Yeh Chih-Fan , Huang Ching-Chang , Chen Ying-Hsien , Chan Chih-Yang , Lin Lung-Chun , Wang Ming-Jiuh , Chen Yih-Sharng , Lin Mao-Shin 
Published: November 2023

AbstractTrans-femoral transcatheter aortic valve replacement (TF-TAVR) performed under conscious sedation (LACS) is not yet become routine practice in Taiwan. We aimed to compared the results between patients received general anesthesia (GA) versus LACS. Our cohort was divided into 3 groups: initial 48 patients received TF-TAVR under routine GA (GA group), subsequent 50 patients under routine LACS (LACS group 1), and recent 125 patients under LACS (LACS group 2). The baseline, procedural characteristics and all outcomes were prospectively collected and retrospectively compared. From Sep 2010 to July 2019, a total of 223 patients were included. The procedure time (157.6 ± 39.4 min vs 131.6 ± 30.3 vs 95.2 ± 40.0, < 0.0001), contrast medium consumption (245.6 ± 92.6 ml vs 207.8 ± 77.9 vs 175.1 ± 64.6, < 0.0001), length of intensive care unit (2 [1–5] days vs 2 [1–3] vs 1 [1–1], P = 0.0001) and hospital stay (9 [7–13] days vs 8 [6–11] vs 6 [5–9], P = 0.0001) decreased significantly with LACS, combined with a trend of less hospital acquired pneumonia (12.5% vs 6.0% vs 5.6%, P = 0.427). 1-year survival rate were also different among 3 groups (83.3% vs 90.0% vs 93.6%, P = 0.053). In our single center experience, a “minimalist” approach of TF-TAVR procedure resulted in less medical resources usage, along with more favorable clinical outcomes.
Impact of cardiac rehabilitation on cardiovascular event in Korea
Authors: Song In Sun , Park Yu shin , Jang Suk-Yong , Nam Jung Mo , Lee Chan Joo , Park Eun-Cheol 
Published: November 2023

AbstractThis study aimed to evaluate the effects of cardiac rehabilitation (CR) on major adverse cardiac events (MACE) among patients who underwent PCI procedure. We used data from the electronic medical records (EMR) of a tertiary hospital in Seoul, Korea, from January 2014 to February 2020. Data from 2988 patients who had experienced their first acute coronary syndrome (ACS) and had undergone percutaneous coronary intervention (PCI) were included during the study period. we classified patients into CR participants and non-participants based on their participation in the cardiac rehabilitation (CR) program within 30 days after discharge. And the outcome was the incidence of myocardial infarction (MI) and stroke within 1 year after discharge. The association between participation in CR and risk of developing MACE was evaluated using the Cox proportional hazards model. Patients who achieved CR after undergoing PCI were at a lower risk of developing MI (HR 0.68, CI 0.53–0.86). There was no significant association between participation in CR and the incidence of stroke. Among patients who had more than three stenotic vessels, the risk of developing MI within 1 year of discharge was reduced in CR users compared to non-users (3 or more stenosis vessels: HR 0.55, CI 0.35–0.86). Among patients who used two and more stents during PCI procedures, the risk of developing MI within 1 year of discharge was reduced in CR users compared to non-users (2 and more stents: HR 0.54, CI 0.35–0.85). Among people diagnosed with ACS and receiving PCI, patients who participated in CR within one month of discharge reduced risk of developing MI. Our study reinforced the current evidence on the effect of CR among patients receiving PCI and presented the expansion and enhancement of the CR program.
Transformation of foldable robotic hand to scissor-like shape for pinching based on human hand movement
Authors: Ikeda Hidetoshi , Saeki Takumi 
Published: November 2023

AbstractIncreasing the number of degrees of freedom for multi-finger robotic hands is necessary to achieve high performance. However, this increases structural complexity and the obtained improvement may be small. Humans change the shape of their hands by extending or bending the fingers to apply force to an object through contact with a wide surface or two or more fingers. In some cases, continuous finger movements are not necessary or some fingers do not make contact with the object. A robotic hand with a small number of degrees of freedom could effectively use its fingers to perform many tasks by properly arranging the fingers, increasing the movable range of joints, and utilizing the back and sides of the fingers. This paper proposes a hand system and conducts a theoretical analysis of the transformation of the hand shape into a scissor-like motion to handle a cylindrical object. It is found that the scissor-like motion is unsuitable for cylindrical objects that exceed a certain size. Experiments show the effectiveness of the proposed hand system. The correlation between the contact position of a finger with an object and the success ratio of pinching is demonstrated. Furthermore, a control system that can switch from pinching to grasping when the robot judges that pinching is difficult is developed and experimentally validated.
Acoustic and Physiologic Correlates of Vocal Effort in Individuals With and Without Primary Muscle Tension Dysphonia
Authors: Toles Laura E. , Shembel Adrianna C. 
Published: November 2023

Objectives:
The aims of this study were to determine relationships between vocal effort and (a) acoustic correlates of vocal output and (b) supraglottic compression in individuals with primary muscle tension dysphonia (pMTD) and without voice disorders (controls) in the context of a vocal load challenge.

Method:
Twenty-six individuals with pMTD and 35 vocally healthy controls participated in a 30-min vocal load challenge. The pre- and postload relationships among self-ratings of vocal effort, various acoustic voice measures, and supraglottic compression (mediolateral and anteroposterior) were tested with multiple regression models and post hoc Pearson's correlations. Acoustic measures included cepstral peak prominence (CPP), low-to-high spectral ratio, difference in intensity between the first two harmonics, fundamental frequency, and sound pressure level (dB SPL).

Results:
Regression models for CPP and mediolateral compression were statistically significant. Vocal effort, diagnosis of pMTD, and vocal demand were each significant variables influencing CPP measures. CPP was lower in the pMTD group across stages. There was no statistical change in CPP following the vocal load challenge within either group, but both groups had an increase in vocal effort postload. Vocal effort and diagnosis influenced the mediolateral compression model. Mediolateral compression was higher in the pMTD group across stages and had a negative relationship with vocal effort, but it did not differ after vocal loading.

Conclusions:
CPP and mediolateral supraglottic compression were influenced by vocal effort and diagnosis of pMTD. Increased vocal effort was associated with lower CPP, particularly after vocal load, and decreased mediolateral supraglottic compression in the pMTD group.
Die besondere Rolle des Modellvorhabens nach § 64b SGB V für die psychiatrische Adoleszentenstation in Riedstadt
Authors: Duve Annette , Jürgens Sevinc , Pluschke Lena-Sophie , von Peter Sebastian , Schwarz Julian 
Published: November 2023

ZUSAMMENFASSUNGDie Trennung von Kinder- und Jugend- (KJP) und Erwachsenenpsychiatrie (EP) führt zu Brüchen in der Versorgung und verhindert eine sachgerechte und kontinuierliche Behandlung der Gruppe der Adoleszenten. Um dies zu überwinden, wurde am Vitos Klinikum Riedstadt 2019 eine Adoleszentenstation (AS) implementiert, welche erstmals eine sektorenübergreifende Behandlung von 16- bis 25-Jährigen ermöglicht. Die AS wurde auf Basis eines psychiatrischen Modellvorhabens nach § 64b SGB V, welches am Standort Riedstadt sowohl die KJP als auch die EP und nahezu alle Kostenträger umfasst, entwickelt.Der vorliegende Artikel gibt einen Überblick auf den Stand neuerer Versorgungsansätze im Bereich der Adoleszentenpsychiatrie in Deutschland, die Umsetzung der AS und des Modellvorhabens am Standort Riedstadt und stellt ein begleitendes Forschungsprojekt (EvAdoR-Studie) vor. Abschließend wird der Zusammenhang von Modellvorhaben und Adoleszentenpsychiatrie diskutiert.
Am Anfang war das Regionalbudget
Authors: Deister Arno , Wilms Bettina 
Published: November 2023

ZUSAMMENFASSUNGBeginnend mit den Regionalen Psychiatrie-Budgets wurden in Schleswig-Holstein im Rahmen sich verändernder gesetzlicher Grundlagen Modellprojekte in der psychiatrisch-psychotherapeutischen Versorgung mit den Mitteln des Krankenhauses konzipiert und umgesetzt. Seit 1999 entwickelten Protagonisten aus Politik, von Kostenträgern und Krankenhausmedizin ein verändertes Finanzierungsmodell. Ziel war es, die Behandlung für eine definierte Population einer Region flexibler gestalten zu können. Seit 2012 sind die vormals vertraglich vereinbarten Modelle in Regelungen nach § 64b SGB V übergegangen. Die Regelungen zur Finanzierung und die darauffolgenden Verbesserungen für die Patientenversorgung werden dargestellt.
The peaceful use of outer space: protecting life on Earth
Authors: Freeland Steven 
Published: November 2023

AbstractThe way we explore and use of outer space is fundamental in terms of the world economy, strategic thinking, terrestrial military strategy, geopolitics, human rights, commercial enterprise, tech innovation and, frankly, the future of humankind. The impact of our use of space and the increasing range of space activities mean that law has an important role in ensuring that such activities are carried out in an appropriate manner. But law is not enough. We need to adjust our mindset about the use of space to recognise its uniqueness and the ‘humanity’ and ‘common interest’ doctrines that underpin it. A claim by some elements of society that space is the new ‘warfighting domain’ contradicts the 6-decade-long understanding that it is a shared area governed by international law, where global interests converge to ensure its exploration and use for the benefit of humanity. The goal of preventing an arms race in outer space (PAROS) is vital and must be continued, yet it still contemplates and may even legitimise increased military uses of space. We need to set our ambitions even higher—a pursuit of a ‘peace race’ in space. Only then can we begin to move towards an even broader aspirational goal of utilising international human rights law to protect humanity for all threats that might emerge from activities taken above us.
Author Correction to “Mesoscale Simulation of Vesiculation of Lipid Droplets”
Authors: Xu Rui , Wang Zi-lu , He Xue-hao 
Published: November 2023

We regret to announce that two parameters (θ0, rc) were found incorrect after publication due to the author’s typing errors. The two parameters were published in Chin. J. Chem. Phys. 27, 663–671 (2014). DOI: https://doi.org/10.1063/1674-0068/27/06/663-671.
In page 664, in the sentence “Similarly, a small equilibrium angle (θ0 = 10°) with the bending constant (kangle = 20 kJ/(mol·rad2)) is empirically selected to stabilize the bilayer structure.”, “θ0 = 10°” should be corrected as “θ0 = 30°”.
In page 665, in the sentence “In the present CG model rc is set as 2.772 nm and the start position of r1 = 2.25 nm.”, “rc is set as 2.772 nm” should be corrected as “rc is set as 2.722 nm”.
The two parameters (θ0, rc) of the model used in the work are the same as those of the work [J. Phys. Chem. B 120, 2262–2270 (2016)].
Variational quantum state discriminator for supervised machine learning
Authors: Lee Dongkeun , Baek Kyunghyun , Huh Joonsuk , Park Daniel K 
Published: November 2023

Abstract
Quantum state discrimination (QSD) is a fundamental task in quantum information processing with numerous applications. We present a variational quantum algorithm that performs the minimum-error QSD, called the variational quantum state discriminator (VQSD). The VQSD uses a parameterized quantum circuit that is trained by minimizing a cost function derived from the QSD, and finds the optimal positive-operator valued measure (POVM) for distinguishing target quantum states. The VQSD is capable of discriminating even unknown states, eliminating the need for expensive quantum state tomography. Our numerical simulations and comparisons with semidefinite programming demonstrate the effectiveness of the VQSD in finding optimal POVMs for minimum-error QSD of both pure and mixed states. In addition, the VQSD can be utilized as a supervised machine learning algorithm for multi-class classification. The area under the receiver operating characteristic curve obtained in numerical simulations with the Iris flower dataset ranges from 0.97 to 1 with an average of 0.985, demonstrating excellent performance of the VQSD classifier.
A community resource to mass explore the wheat grain proteome and its application to the late-maturity alpha-amylase (LMA) problem
Authors: Vincent Delphine , Bui AnhDuyen , Ezernieks Vilnis , Shahinfar Saleh , Luke Timothy , Ram Doris , Rigas Nicholas , Panozzo Joe , Rochfort Simone , Daetwyler Hans , Hayden Matthew 
Published: November 2023

Abstract

Background
Late-maturity alpha-amylase (LMA) is a wheat genetic defect causing the synthesis of high isoelectric point alpha-amylase following a temperature shock during mid-grain development or prolonged cold throughout grain development, both leading to starch degradation. While the physiology is well understood, the biochemical mechanisms involved in grain LMA response remain unclear. We have applied high-throughput proteomics to 4,061 wheat flours displaying a range of LMA activities. Using an array of statistical analyses to select LMA-responsive biomarkers, we have mined them using a suite of tools applicable to wheat proteins.

Results
We observed that LMA-affected grains activated their primary metabolisms such as glycolysis and gluconeogenesis; TCA cycle, along with DNA- and RNA- binding mechanisms; and protein translation. This logically transitioned to protein folding activities driven by chaperones and protein disulfide isomerase, as well as protein assembly via dimerisation and complexing. The secondary metabolism was also mobilized with the upregulation of phytohormones and chemical and defence responses. LMA further invoked cellular structures, including ribosomes, microtubules, and chromatin. Finally, and unsurprisingly, LMA expression greatly impacted grain storage proteins, as well as starch and other carbohydrates, with the upregulation of alpha-gliadins and starch metabolism, whereas LMW glutenin, stachyose, sucrose, UDP-galactose, and UDP-glucose were downregulated.

Conclusions
To our knowledge, this is not only the first proteomics study tackling the wheat LMA issue but also the largest plant-based proteomics study published to date. Logistics, technicalities, requirements, and bottlenecks of such an ambitious large-scale high-throughput proteomics experiment along with the challenges associated with big data analyses are discussed.
Impact of Fc receptors and host characteristics on myeloid phagocytic response to rituximab-treated 3D-cultured B-cell lymphoma
Authors: Kleinau Sandra 
Published: November 2023

Summary
Antibody-based immunotherapy is successful in treating cancer, but its effectiveness varies among patients. Therefore, understanding myeloid phagocytic responses to therapeutic antibodies is critical. Immunoglobulin Fc receptors and host characteristics were evaluated in phagocytosis of 3D-cultured CD20+ B-cell lymphoma (spheroids) treated with different anti-CD20 rituximab (RTX) monoclonal antibody isotypes. Monocytes from healthy donors of different ages and sexes were isolated, and their Fc receptors for IgG (FcγRI, FcγRIIa, FcγRIIIa) and IgA (FcαRI) were determined, as well as Fc receptor gene polymorphisms. Antibody-dependent phagocytosis was assessed using flow cytometry, confocal imaging, and Fc receptor blocking. RTX isotypes showed varying efficacy in stimulating the phagocytosis of spheroids. RTX-IgG3 proved to be the most efficient, followed by RTX-IgG1. Monocytes infiltrated RTX-treated spheroids at the periphery but migrated also into the core when stimulated with RTX-IgG3. Blocking FcγRI or FcγRIIa, but not FcγRIIIa, with antibodies inhibited RTX-IgG1 and RTX-IgG3-mediated phagocytosis. Monocytes from younger women demonstrated higher FcγRI and FcγRIIa levels compared to older women, while older men displayed increasing FcγRI and FcγRIIIa levels compared to younger men. Monocytes from younger women displayed greater phagocytic activity compared to older women, while older men had better IgG-mediated phagocytosis than younger men. Single Fc receptor levels, or FcγRIIa and FcγRIIIa genetic variants, had a low correlation with phagocytic intensity, likely as a result of multiple engagements of Fcreceptors for IgG-mediated phagocytosis. In conclusion, antibody isotype, Fc receptors, age, and sex influence tumor phagocytosis. This study exposes the relationship between host traits and the efficacy of therapeutic antibodies, providing insights into cancer immunotherapy treatment.
Impact of revised breakpoints on the categorization of susceptibility of Enterobacterales to temocillin
Authors: Farfour Eric , Le Brun Cécile , Degand Nicolas , Riverain Emeline , Dinh Aurélien , Timores Thierry , Mamona Christel , Vallée Alexandre , Vasse Marc 
Published: November 2023

Abstract

Background
To harmonize with the EUCAST breakpoints, the French Society of Microbiology introduced a change in the inhibition diameter breakpoint (17 mm versus 20 mm previously) of temocillin. We assessed the impact of the new breakpoints on categorizing susceptibility of Enterobacterales to temocillin.

Methods
This was a multicentric retrospective study including all Enterobacterales isolates routinely tested for temocillin susceptibility with the disc diffusion method between 1 January 2016 and 31 July 2022 in four centres. Categorization using the breakpoints of 20 mm (French guidelines CA-SFM/EUCAST 2020 v.1.1) and 17 mm (French guidelines CA-SFM/EUCAST 2021 v1.0 and EUCAST guidelines v11.0) was performed.

Results
Overall, 36 416 Enterobacterales isolates were included. The overall rate of temocillin resistance decreased from 11.3% to 4.7% (relative difference of 58.5%) when using the 17 mm breakpoint instead of the 20 mm breakpoint, respectively. The relative change ranged from −44.0% in Klebsiella aerogenes to −72.7% in Klebsiella oxytoca. The median inhibition diameter was 23 mm (IQR 21–25). The isolates with a diameter of 20 mm appeared overrepresented, whereas those with a diameter of 18 and 19 mm were underrepresented. We therefore reviewed the diameters between 18 and 21 mm of 273 isolates. Thirty-two (11.7%) of them categorized as susceptible at first measure were controlled resistant at second measure.

Conclusions
The new breakpoint induced a decrease in the rate of isolates categorized as resistant to temocillin, increasing therapeutic choice including for Extended-spectrum beta-lactamase-producing Enterobacterales (ESBL-PE). We suggest the bias in measuring the inhibition diameter is probably related to the fact that temocillin is considered remarkably stable against broad-spectrum β-lactamases.
Pharmacology of dental local anaesthesia
Authors: Meechan John G , Robb Nigel D , Seymour Robin A 
Published: November 2023

Abstract
Local anaesthesia is defined as a loss of sensation in a circumscribed area of the body by a depression of excitation in nerve endings or an inhibition of the conduction process in peripheral nerves. The term ‘anaesthesia’ denotes absence of all sensation including touch, temperature, pressure, and pain. In clinical practice it is a localized loss of pain sensation that is desired. The correct term for a localized loss of pain is ‘local analgesia’. The expressions ‘local anaesthesia’ and ‘local analgesia’ are used almost synonymously in dentistry. In this book the former term will be used throughout.
Poetry of Transition II (1914-1919)
Authors: Rosenthal M L 
Published: November 2023

Abstract
Yeats’s next books of new poetry after Responsibilities were The Wild Swans at Coale (1917; enlarged edition, 1919) and Michael Robartes and the Dancer (1921). All the poems in these books had been written by early 1919, for the most part during the preceding three or four years. The two collections reveal interesting reciprocities and, since the later book is very short, might well have been combined. This chapter will therefore consider them together, or at least as companion volumes.
Poetry after The Tower
Authors: Rosenthal M L 
Published: November 2023

Abstract
The Winding Stair and Other Poems (1933) climbed its own winding stair over a period of four years to find its final shape: an untitled opening section of twenty-seven poems, followed by the two sequences “Words for Music Perhaps” and “A Woman Young and Old.” The brief history of its growth is worth noting because Yeats was slowly discovering the organic relationships implicit in it.
Philip’s Phoenix
Authors: Hannay Margaret P 
Published: November 2023

Abstract
Although previous studies have portrayed Mary Sidney as a demure, retiring woman, Hannay, basing her work on primary sources (account books, legal documents, diaries, family letters), has discovered that she was brilliant, learned, witty, articulate, and adept at self-presentation. Married to the wealthy Earl of Pembroke, she ruled over her little court at Wilton just as Elizabeth ruled in London. Her wisdom, poetry, and scholarship were extravagantly praised by those who sought to gain her favour. When Philip, her older brother, died fighting for the Protestant cause, she moved to London to take up his literary activities, publishing his writings, writing and translating works of which he would have approved, assuming his role as literary patron and supporting the Protestant cause for which he died. All the literary work for which she is celebrated took place between her return to London in 1588 and her husband's death in 1601. While previous biographers contended that her widowhood was quiet and uneventful, Hannay shows, via court cases, that her final years were colourful indeed, as, administering the properties she retained, she contended with jewel thieves, pirates, and murderers, finally bringing them to trial after complex legal and political manoeuvres.
The White Doe of Rylstone, The Convention of Cintra, and the History of a Career
Authors: Manning Peter J 
Published: November 2023

Abstract
The story of how Wordsworth delayed publishing The White Doe of Rylstone, finished in 1807-08, until 1815 is familiar. The received account runs like this: the poem represented Wordsworth’s effort to transform materials from the north of England and the borders, the stuff of romance and ballad which Sir Walter Scott had mined so successfully, into an exemplum of imagination and faith, but the poem proved too spiritual and lacking in adventure for those who heard or read the manuscript-Coleridge, Lamb, Hazlitt, Jane Marshall-and, discouraged, Wordsworth kept it back.
Ayin: The Concept of Nothingness in Jewish Mysticism
Authors: Matt Daniel C 
Published: November 2023

Abstract
There is allure and terror in mystical portrayals of nothingness: Eckhart’s Nichts, John of the Cross’s nada, the Taoist wu, the Buddhist sunyata. Despite appearances, these terms do not express an identical meaning since each mystic names the nameless from within a realm of discourse shaped by his own training, outlook, and language. My aim here is to trace the development of the concept of ayin (nothingness) in Jewish mysticism. In medieval Kabbalah ayin functions as a theosophical symbol, part of the elaborate system of the sefirot, the stages of divine manifestation. Everything emerges from the depths of ayin and eventually returns there. As we proceed from Kabbalah to Hasidism, the focus changes. Now the psychological significance of ayin is emphasized and it becomes a medium for self-transformation. The mystic experiences ayin directly and emerges anew.