bluuebunny/crossref_metadata_2025_split huggingface dataset:
Art and the Lived Experience of Pain
Authors: Vassilopoulou Panayiota 
Published: September 2023

AbstractMental health has become a key concern within social discourse in recent years, and with it, the discussion about the lived experience of pain. In dealing with this experience there has been a shift away from merely relying on medical care towards more holistic approaches involving community support, public awareness, and social change. However, little if any attention has been paid in this context to the contribution of aesthetic experience engendered by art that expresses and publicly shares with others the lived experience of pain. With reference to Phantom Limb, an art exhibition curated by Euan Grey and held at the Victoria Galleries and Museum Liverpool in 2016, I argue that aesthetic experience plays a crucial role in making sense of pain and suffering, thus breaking new ground in the appreciation of the significance of art for public mental health and holistic approaches towards patients.
ALGEBRAIC SEMANTICS FOR RELATIVE TRUTH, AWARENESS, AND POSSIBILITY
Authors: PIERMONT EVAN 
Published: September 2023

AbstractThis paper puts forth a class of algebraic structures, relativized Boolean algebras (RBAs), that provide semantics for propositional logic in which truth/validity is only defined relative to a local domain. In particular, the join of an event and its complement need not be the top element. Nonetheless, behavior is locally governed by the laws of propositional logic. By further endowing these structures with operators—akin to the theory of modal Algebras—RBAs serve as models of modal logics in which truth is relative. In particular, modal RBAs provide semantics for various well-known awareness logics and an alternative view of possibility semantics.
PWV Retrieval Performance Evaluation for the Fresh BDS‐3 With Multisource Data
Authors: Jiang Nan , Gao Zhaorui , Wu Yuhao , Xu Yan , Xu Tianhe , Li Song , Guo Ao 
Published: September 2023

AbstractThe entire global operation of the newly launched BDS global navigation satellite system (BDS‐3) was completed in July 2020. After that, a series of performance tests were conducted, such as positioning, navigation, and signal experiments. However, the precipitable water vapor (PWV) retrieval performance evaluation of BDS‐3 has not yet been carried out, so in this paper, we thoroughly verified its accuracy with AIRS v7, ERA5, and radiosonde data to know the current performance of BDS‐3 PWV. From the tests applied with different satellite systems, we found that BDS‐3 has a comparable PWV retrieval performance as global positioning system (GPS), and a better outcome was achieved using the combined data from GPS and BDS‐3. Furthermore, BDS‐3 PWV accuracy calibrated by AIRS v7 showed a strong correlation with the spatial distribution. In addition, the PWV content decreased with the climbing of the latitude and elevation, and the relative root mean square error (ReRMSE) indicated better in the low‐latitude areas. Finally, the effect of different surface types on PWV performance was analyzed, showing the BDS‐3 PWV accuracy in the land type was the highest, the sea one was the lowest, and the coast type was in the middle. These findings will provide a good reference for the community to understand the PWV performance of BDS‐3 at the present stage.
Variations of Crustal Thickness in Alaska and Northwestern Canada: Implications for Crustal Modification and Accretion of Tectonic Units
Authors: Liu Meng , Gao Haiying 
Published: September 2023

AbstractThe northwestern part of North America has recorded multiple tectonic events, such as terrane accretion, strike‐slip motion, and subduction of the Pacific and Yakutat plates, providing an iconic setting to investigate the tectonic evolution of the continental crust. In this study we analyze the receiver functions at seismic stations deployed during 1999–2022 to estimate the crustal thickness, as well as possible slab signature, in Alaska and northwestern Canada. The Moho signal can be clearly detected within the continental region. Specifically, in northwestern Canada, the thickest crust is observed beneath the Cordilleran Deformation Front, which marks the structural boundary between the North American Craton and the North American Margin. We observe a few distinct offsets in the Moho depth located both within the tectonic units and approximately across the major faults between the tectonic units. We provide a first‐order estimate of the depth gradient of the Moho offsets based on the horizontal distance of the two closest seismic stations across the offsets. We propose that the Moho offsets reflect the cumulative impact of the accretionary orogenies and post‐orogenic tectonic events on crustal modification. The continental Moho signal is weak or obscure in Aleutian and southcentral Alaska, and the oceanic Moho within the subducting plates is likely detected. This study provides new seismic insights into understanding the impacts of the tectonic events on continental formation and evolution.
Deformation Sequence and Paleofluids in Carbonate Buckle Folds Under Transpression (Pag Anticline, External Dinarides, Croatia)
Authors: Lucca A. , Mittempergher S. , Succo A. , Bistacchi A. , Meda M. , Storti F. 
Published: September 2023

AbstractContractional deformation structures at the front of transpressional orogens display complex three‐dimensional geometries deviating from the interpretative templates commonly applied in thrust belts. Accordingly, detailed constraints on deformation patterns and associated paleofluid circulation are desirable, especially for fracture geometry and permeability predictive purposes. The Pag anticline, which is located in the Dinaric fold and thrust belt, provides an appropriate field site for studying fold‐ and fault‐related deformation structures in a transpressive setting. We performed a multiscale structural analysis together with petrographic and stable isotope characterization of the deformation‐related calcite cements. Structural mapping suggests that the Pag anticline is a detachment fold developed mainly by buckling, since large‐scale thrust faults are absent. Fold tightening in a transpressive setting produced a complex deformational structure including two sets of N‐S right‐lateral and E‐W left‐lateral late‐stage strike‐slip fault sets trending oblique to the NW‐SE fold axis. The pre‐folding deformation pattern includes incipient normal faults likely related to the forebulge stage, veins and stylolites coherent with NE‐SW layer parallel shortening contraction in a strike‐slip regime, and metric to decametric scale conjugate thrusts coherent with layer parallel shortening in a compressive regime. Buckle folding preceded propagation of a series of accommodation structures during fold tightening. Petrographic and isotopic data indicate meteoric alteration of the Cretaceous platform carbonates in the prefolding stage, likely due to forebulge subaerial exposure. Layer parallel shortening and early syn‐folding veins involved formational fluids resulting from mixed marine and meteoric fluids during folding at shallow burial conditions. Eventually, meteoric fluid infiltrated again along strike‐slip faults, acting as cross‐formational conduits in the postfolding stage.
Investigating the Impact of Seawater Intrusion on the Operation Cost of Groundwater Supply in Island Aquifers
Authors: Yu Weijiang , Baù Domenico , Mayer Alex S. , Mancewicz Lauren , Geranmehr Mohammadali 
Published: September 2023

AbstractManaging fragile island freshwater resources requires identifying pumping strategies that trade off the financial cost of groundwater supply against controlling the seawater intrusion (SWI) associated with aquifer pumping. In this work, these tradeoffs are investigated through a sensitivity analysis conducted in the context of an optimization formulation of the groundwater management problem, which aims at minimizing the groundwater supply operation cost associated with groundwater pumping and desalination treatment, subject to constraints on SWI control, as quantified by the water table drawdown over the well (∆s), the reduction in freshwater volume (∆FV) in the aquifer, or the salt mass increase (∆SM) in the aquifer. This study focuses on a simplified two‐dimensional model of the San Salvador Island aquifer (Bahamas). Pumping strategies are characterized by the distance of the pumping system from the shoreline (WL), the abstraction screen depth (D) and overall pumping rate (Q), constituting the decision variables of the optimization problem. We investigate the impacts of pumping strategies on the operation cost, ∆s, ∆FV and ∆SM. Findings indicate increasing D or decreasing WL reduces ∆s, ∆FV and ∆SM, thus preserving the aquifer hydrogeologic stability, but also leads to extracting saltier groundwater, thus increasing the water treatment requirements, which have a strong impact on the overall groundwater supply cost. From a financial perspective, groundwater abstraction near the island center and at shallow depths seems the most convenient strategy. However, the analysis of the optimization constraints reveals that strategies where the pumping system approaches the island center tend to cause more severe SWI, highlighting the need to trade off groundwater supply cost against SWI control.
Antler stem cell exosomes alleviate pulmonary fibrosis via inhibiting recruitment of monocyte macrophage, rather than polarization of M2 macrophages in mice
Authors: Zhang Guokun , Shi Liyan , Li Jiping , Wang Shengnan , Ren Jing , Wang Dongxu , Hu Pengfei , Wang Yimin , Li Chunyi 
Published: September 2023

AbstractPulmonary fibrosis (PF), a chronic interstitial lung disease, is characterized by over-abundant deposition of extracellular matrix consisting mainly of collagen I. In previous studies, we demonstrated that deer antler stem cells (AnSCs), a novel type of adult stem cell, are capable of significantly down-regulating collagen formation in different organs and tissues and speculated that they could effectively treat PF via reducing collagen deposition in the lung tissue. In the present study, we found that administration of AnSCs improved the survival rate of PF mice and reduced lung fibrosis, collagen deposition and myofibroblast differentiation. The effects of AnSC treatment were significantly better than the positive control (adipose-derived stem cells). Interestingly, AnSC-Exos were almost equally effective as AnSCs in treating PF, suggesting that the effects of AnSCs on reduction of PF may be mainly through a paracrine mechanism. Further, AnSC-Exos reduced the number of M2 macrophages, a type of macrophage that secrets pro-fibrotic factors to accelerate fibrotic progression, in the lung tissues. In vitro experiments showed that the effects of AnSC-Exos on macrophage modulation were likely achieved via inhibition of the recruitment of circulating monocyte-derived macrophages (reducing the number of macrophages), rather than via inhibition of M2 polarization of macrophages. Inhibition of macrophage recruitment by AnSCs may be achieved indirectly via inhibiting CCL7 expression in fibroblasts; both let-7b and let-7a were highly enriched in AnSC-Exos and may play a critical role in the inhibition of CCL7 expression of fibroblasts. Collectively, the use of antler stem cells or their exosomes opens up a novel strategy for PF treatment in the clinical setting.
Genome-wide association studies and cross-population meta-analyses investigating short and long sleep duration
Authors: Austin-Zimmerman Isabelle , Levey Daniel F. , Giannakopoulou Olga , Deak Joseph D. , Galimberti Marco , Adhikari Keyrun , Zhou Hang , Denaxas Spiros , Irizar Haritz , Kuchenbaecker Karoline , McQuillin Andrew ,   the Million Veteran Program, Concato John , Buysse Daniel J. , Gaziano J. Michael , Gottlieb Daniel J. , Polimanti Renato , Stein Murray B. , Bramon Elvira , Gelernter Joel 
Published: September 2023

AbstractSleep duration has been linked to a wide range of negative health outcomes and to reduced life expectancy. We present genome-wide association studies of short ( ≤ 5 h) and long ( ≥ 10 h) sleep duration in adults of European (N = 445,966), African (N = 27,785), East Asian (N = 3141), and admixed-American (N = 16,250) ancestry from UK Biobank and the Million Veteran Programme. In a cross-population meta-analysis, we identify 84 independent loci for short sleep and 1 for long sleep. We estimate SNP-based heritability for both sleep traits in each ancestry based on population derived linkage disequilibrium (LD) scores using cov-LDSC. We identify positive genetic correlation between short and long sleep traits (rg = 0.16 ± 0.04; p = 0.0002), as well as similar patterns of genetic correlation with other psychiatric and cardiometabolic phenotypes. Mendelian randomisation reveals a directional causal relationship between short sleep and depression, and a bidirectional causal relationship between long sleep and depression.
Minimum entropy production by microswimmers with internal dissipation
Authors: Daddi-Moussa-Ider Abdallah , Golestanian Ramin , Vilfan Andrej 
Published: September 2023

AbstractThe energy dissipation and entropy production by self-propelled microswimmers differ profoundly from passive particles pulled by external forces. The difference extends both to the shape of the flow around the swimmer, as well as to the internal dissipation of the propulsion mechanism. Here we derive a general theorem that provides an exact lower bound on the total, external and internal, dissipation by a microswimmer. The problems that can be solved include an active surface-propelled droplet, swimmers with an extended propulsive layer and swimmers with an effective internal dissipation. We apply the theorem to determine the swimmer shapes that minimize the total dissipation while keeping the volume constant. Our results show that the entropy production by active microswimmers is subject to different fundamental limits than the entropy production by externally driven particles.
Integrated molecular and multiparametric MRI mapping of high-grade glioma identifies regional biologic signatures
Authors: Hu Leland S. , D’Angelo Fulvio , Weiskittel Taylor M. , Caruso Francesca P. , Fortin Ensign Shannon P. , Blomquist Mylan R. , Flick Matthew J. , Wang Lujia , Sereduk Christopher P. , Meng-Lin Kevin , De Leon Gustavo , Nespodzany Ashley , Urcuyo Javier C. , Gonzales Ashlyn C , Curtin Lee , Lewis Erika M. , Singleton Kyle W. , Dondlinger Timothy , Anil Aliya , Semmineh Natenael B. , Noviello Teresa , Patel Reyna A. , Wang Panwen , Wang Junwen , Eschbacher Jennifer M. , Hawkins-Daarud Andrea , Jackson Pamela R. , Grunfeld Itamar S. , Elrod Christian , Mazza Gina L. , McGee Sam C. , Paulson Lisa , Clark-Swanson Kamala , Lassiter-Morris Yvette , Smith Kris A. , Nakaji Peter , Bendok Bernard R. , Zimmerman Richard S. , Krishna Chandan , Patra Devi P. , Patel Naresh P. , Lyons Mark , Neal Matthew , Donev Kliment , Mrugala Maciej M. , Porter Alyx B. , Beeman Scott C. , Jensen Todd R. , Schmainda Kathleen M. , Zhou Yuxiang , Baxter Leslie C. , Plaisier Christopher L. , Li Jing , Li Hu , Lasorella Anna , Quarles C. Chad , Swanson Kristin R. , Ceccarelli Michele , Iavarone Antonio , Tran Nhan L. 
Published: September 2023

AbstractSampling restrictions have hindered the comprehensive study of invasive non-enhancing (NE) high-grade glioma (HGG) cell populations driving tumor progression. Here, we present an integrated multi-omic analysis of spatially matched molecular and multi-parametric magnetic resonance imaging (MRI) profiling across 313 multi-regional tumor biopsies, including 111 from the NE, across 68 HGG patients. Whole exome and RNA sequencing uncover unique genomic alterations to unresectable invasive NE tumor, including subclonal events, which inform genomic models predictive of geographic evolution. Infiltrative NE tumor is alternatively enriched with tumor cells exhibiting neuronal or glycolytic/plurimetabolic cellular states, two principal transcriptomic pathway-based glioma subtypes, which respectively demonstrate abundant private mutations or enrichment in immune cell signatures. These NE phenotypes are non-invasively identified through normalized K2 imaging signatures, which discern cell size heterogeneity on dynamic susceptibility contrast (DSC)-MRI. NE tumor populations predicted to display increased cellular proliferation by mean diffusivity (MD) MRI metrics are uniquely associated with EGFR amplification and CDKN2A homozygous deletion. The biophysical mapping of infiltrative HGG potentially enables the clinical recognition of tumor subpopulations with aggressive molecular signatures driving tumor progression, thereby informing precision medicine targeting.
Tunable backbone-degradable robust tissue adhesives via in situ radical ring-opening polymerization
Authors: Yang Ran , Zhang Xu , Chen Binggang , Yan Qiuyan , Yin Jinghua , Luan Shifang 
Published: September 2023

AbstractAdhesives with both robust adhesion and tunable degradability are clinically and ecologically vital, but their fabrication remains a formidable challenge. Here we propose an in situ radical ring-opening polymerization (rROP) strategy to design a backbone-degradable robust adhesive (BDRA) in physiological environment. The hydrophobic cyclic ketene acetal and hydrophilic acrylate monomer mixture of the BDRA precursor allows it to effectively wet and penetrate substrates, subsequently forming a deep covalently interpenetrating network with a degradable backbone via redox-initiated in situ rROP. The resulting BDRAs show good adhesion strength on diverse materials and tissues (e.g., wet bone >16 MPa, and porcine skin >150 kPa), higher than that of commercial cyanoacrylate superglue (~4 MPa and 56 kPa). Moreover, the BDRAs have enhanced tunable degradability, mechanical modulus (100 kPa-10 GPa) and setting time (seconds-hours), and have good biocompatibility in vitro and in vivo. This family of BDRAs expands the scope of medical adhesive applications and offers an easy and environmentally friendly approach for engineering.
Biomolecular condensates modulate membrane lipid packing and hydration
Authors: Mangiarotti Agustín , Siri Macarena , Tam Nicky W. , Zhao Ziliang , Malacrida Leonel , Dimova Rumiana 
Published: September 2023

AbstractMembrane wetting by biomolecular condensates recently emerged as a key phenomenon in cell biology, playing an important role in a diverse range of processes across different organisms. However, an understanding of the molecular mechanisms behind condensate formation and interaction with lipid membranes is still missing. To study this, we exploited the properties of the dyes ACDAN and LAURDAN as nano-environmental sensors in combination with phasor analysis of hyperspectral and lifetime imaging microscopy. Using glycinin as a model condensate-forming protein and giant vesicles as model membranes, we obtained vital information on the process of condensate formation and membrane wetting. Our results reveal that glycinin condensates display differences in water dynamics when changing the salinity of the medium as a consequence of rearrangements in the secondary structure of the protein. Remarkably, analysis of membrane-condensates interaction with protein as well as polymer condensates indicated a correlation between increased wetting affinity and enhanced lipid packing. This is demonstrated by a decrease in the dipolar relaxation of water across all membrane-condensate systems, suggesting a general mechanism to tune membrane packing by condensate wetting.
Global mapping of RNA-chromatin contacts reveals a proximity-dominated connectivity model for ncRNA-gene interactions
Authors: Limouse Charles , Smith Owen K. , Jukam David , Fryer Kelsey A. , Greenleaf William J. , Straight Aaron F. 
Published: September 2023

AbstractNon-coding RNAs (ncRNAs) are transcribed throughout the genome and provide regulatory inputs to gene expression through their interaction with chromatin. Yet, the genomic targets and functions of most ncRNAs are unknown. Here we use chromatin-associated RNA sequencing (ChAR-seq) to map the global network of ncRNA interactions with chromatin in human embryonic stem cells and the dynamic changes in interactions during differentiation into definitive endoderm. We uncover general principles governing the organization of the RNA-chromatin interactome, demonstrating that nearly all ncRNAs exclusively interact with genes in close three-dimensional proximity to their locus and provide a model predicting the interactome. We uncover RNAs that interact with many loci across the genome and unveil thousands of unannotated RNAs that dynamically interact with chromatin. By relating the dynamics of the interactome to changes in gene expression, we demonstrate that activation or repression of individual genes is unlikely to be controlled by a single ncRNA.
Counteranion-mediated efficient iodine capture in a hexacationic imidazolium organic cage enabled by multiple non-covalent interactions
Authors: Yang Jian , Hu Shao-Jun , Cai Li-Xuan , Zhou Li-Peng , Sun Qing-Fu 
Published: September 2023

AbstractDeveloping efficient adsorbents to capture radioactive iodine produced from nuclear wastes is highly desired. Here we report the facial synthesis of a hexacationic imidazolium organic cage and its iodine adsorption properties. Crucial role of counteranions has been disclosed for iodine capture with this cage, where distinct iodine capture behaviors were observed when different counteranions were used. Mechanistic investigations, especially with the X-ray crystallographic analysis of the iodine-loaded sample, allowed the direct visualization of the iodine binding modes at the molecular level. A network of multiple non-covalent interactions including hydrogen bonds, halogen bonds, anion···π interactions, electrostatic interaction between polyiodides and the hexacationic skeleton of the cage are found responsible for the observed high iodine capture performance. Our results may provide an alternative strategy to design efficient iodine adsorbents.
Energy consumption of current and future production of lithium-ion and post lithium-ion battery cells
Authors: Degen F. , Winter M. , Bendig D. , Tübke J. 
Published: September 2023

AbstractDue to the rapidly increasing demand for electric vehicles, the need for battery cells is also increasing considerably. However, the production of battery cells requires enormous amounts of energy, which is expensive and produces greenhouse gas emissions. Here, by combining data from literature and from own research, we analyse how much energy lithium-ion battery (LIB) and post lithium-ion battery (PLIB) cell production requires on cell and macro-economic levels, currently and in the future (until 2040). On the cell level, we find that PLIB cells require less energy than LIB cells per produced cell energy. On the macro-economic level, we find that the energy consumption for the global production of LIB and PLIB cells will be 130,000 GWh if no measures are taken. Yet, it is possible to optimize future production and save up to 66% of this energy demand.