bluuebunny/crossref_metadata_2025_split huggingface dataset:
Association Between Premature Menopause and Cardiovascular Diseases and All‐Cause Mortality in Korean Women
Authors: Lee Gyu Bae , Nam Ga Eun , Kim Wonsock , Han Byoungduck , Cho Kyung Hwan , Kim Seon Mee , Choi Youn Seon , Kim Do Hoon , Park Yong‐Gyu , Jung Jin‐Hyung , Han Kyungdo , Kim Yang‐Hyun 
Published: November 2023

Background
Mortality from cardiovascular diseases in Asian populations is considerable. Menopause is a risk‐enhancing factor for cardiovascular disease, but it is unclear whether menopause is an independent risk factor for cardiovascular disease and mortality in Asian women.

Methods and Results
A total of 1 159 405 postmenopausal women, who had participated in the health examinations of the Korean National Health Insurance Service in 2009, were analyzed, and their reproductive histories were taken. A multivariable Cox proportional hazard model assessed the hazard ratios (HRs) of myocardial infarction (MI), ischemic stroke, and all‐cause mortality, according to the history of premature menopause and age at menopause. After an average 10‐year follow‐up, there were 31 606, 45 052, and 77 680 new cases of MI, ischemic stroke, and all‐cause mortality, respectively. The women with premature menopause exhibited increased risks of MI (HR, 1.40 [95% CI, 1.31–1.50]), ischemic stroke (HR, 1.24 [95% CI, 1.17–1.31]), and all‐cause mortality (HR, 1.19 [95% CI, 1.14–1.24]) when compared with women with menopause aged ≥50 years. The highest risk was evident with menopause between the ages of 30 and 34 years (HR for MI, 1.52 [95% CI, 1.30–1.78]; HR for ischemic stroke, 1.29 [95% CI, 1.12–1.48]; HR for all‐cause mortality, 1.33 [95% CI, 1.20–1.47]) when compared with women with menopause aged ≥50 years.

Conclusions
Earlier age at menopause was associated with increased risks for MI, ischemic stroke, and all‐cause mortality. Future guidelines and risk assessment tools should consider menopause as an independent risk factor of cardiovascular disease in Korean women.
Association Between a First‐Degree Family History and Self‐Reported Personal History of Obesity, Diabetes, and Heart and Blood Conditions: Results From the All of Us Research Program
Authors: Rasooly Danielle , Moonesinghe Ramal , Littrell Kevin , Hull Leland , Khoury Muin J. 
Published: November 2023

Background
Family history reflects the complex interplay of genetic susceptibility and shared environmental exposures and is an important risk factor for obesity, diabetes, and heart and blood conditions (ODHB). However, the overlap in family history associations between various ODHBs has not been quantified.

Methods and Results
We assessed the association between a self‐reported family history of ODHBs and their risk in the adult population (age ≥20 years) of the AoU (All of Us) Research Program, a longitudinal cohort study of diverse participants across the United States. We conducted a family history‐wide association study to systematically assess the association of a first‐degree family history of 15 ODHBs in AoU. We performed stratified analyses based on racial and ethnic categories, education, household income and gender minority status, and quantified associations by type of affected relatives. Of 125 430 participants, 76.8% reported a first‐degree family history of any ODHB, most commonly hypertension (n=64 982, 51.8%), high cholesterol (49 753, 39.7%), and heart attack (29 618, 23.6%). We use the FamWAS method to estimate 225 familial associations among 15 ODHBs. The results include overlapping associations between family history of different types of cardiometabolic conditions (such as type 2 diabetes and coronary artery disease), and their risk factors (obesity, hypertension), where adults with a family history of 1 ODHB exhibited 1.1 to 5.6 times (1.5, on average) the odds of having a different ODHB.

Conclusions
Our findings inform the utility of family history data as a risk assessment and screening tool for the prevention of ODHBs and to provide additional insights into shared risk factors and pathogenic mechanisms.
Sleep‐Disordered Breathing, Hypoxia, and Pulmonary Physiologic Influences in Atrial Fibrillation
Authors: Heinzinger Catherine M. , Thompson Nicolas R. , Milinovich Alex , Diniz Araujo Matheus Lima , Orbea Cinthya Pena , Foldvary‐Schaefer Nancy , Haouzi Philippe , Faulx Michael , Van Wagoner David R. , Chung Mina K. , Mehra Reena 
Published: November 2023

Background
We leverage a large clinical cohort to elucidate sleep‐disordered breathing and sleep‐related hypoxia in incident atrial fibrillation (AF) development given the yet unclear contributions of sleep‐related hypoxia and pulmonary physiology in sleep‐disordered breathing and AF.

Methods and Results

Patients who underwent sleep studies at Cleveland Clinic January 2, 2000, to December 30, 2015, comprised this retrospective cohort. Cox proportional hazards models were used to examine apnea hypopnea index, percentage time oxygen saturation <90%, minimum and mean oxygen saturation, and maximum end‐tidal carbon dioxide on incident AF adjusted for age, sex, race, body mass index, cardiopulmonary disease and risk factors, antiarrhythmic medications, and positive airway pressure. Those with spirometry were additionally adjusted for forced expiratory volume in 1 second, forced vital capacity, and forced expiratory volume in 1 second/forced vital capacity. This cohort (n=42 057) was 50.7±14.1 years, 51.3% men, 74.1% White individuals, had median body mass index 33.2 kg/m
2
, and 1947 (4.6%) developed AF over 5 years. A 10‐unit apnea hypopnea index increase was associated with 2% higher AF risk (hazard ratio [HR], 1.02 [95% CI, 1.00–1.03]). A 10‐unit increase in percentage time oxygen saturation <90% and 10‐unit decreases in mean and minimum oxygen saturation were associated with 6% (HR, 1.06 [95% CI, 1.04–1.08]), 30% (HR, 1.30 [95% CI, 1.18–1.42]), and 9% (HR, 1.09 [95% CI, 1.03–1.15]) higher AF risk, respectively. After adjustment for spirometry (n=9683 with available data), only hypoxia remained significantly associated with incident AF, although all coefficients were stable.

Conclusions
Sleep‐related hypoxia was associated with incident AF in this clinical cohort, consistent across 3 measures of hypoxia, persistent after adjustment for pulmonary physiologic impairment. Findings identify a strong role for sleep‐related hypoxia in AF development without pulmonary physiologic interdependence.
Survival Benefit of Multiple Arterial Revascularization With and Without Supplementary Saphenous Vein Graft
Authors: Ren Justin , Tian David H. , Gaudino Mario , Fremes Stephen , Reid Christopher M. , Vallely Michael , Smith Julian A. , Srivastav Nilesh , Royse Colin , Royse Alistair 
Published: November 2023

Background
It is unknown if the presence of saphenous vein grafting (SVG) adversely affects late survival following coronary surgery with multiple arterial grafting (MAG) versus single arterial grafting.

Methods and Results

A retrospective, observational, multicenter cohort study from 2001 to 2020 was conducted using the Australian and New Zealand Society of Cardiac and Thoracic Surgeons Database linked to the National Death Index. Patients undergoing primary isolated coronary artery bypass grafting with ≥2 grafts were included, and exclusions were patients aged <18 years, reoperations, concomitant or previous cardiac surgery, and the absence of arterial grafting. Demographics, comorbidities, medication, and operative configurations were propensity score matched between cohorts. The primary outcome was all‐cause late death. Of 59 689 eligible patients, 35 113 were MAG (58.8%), and 24 576 were single arterial grafting (41.2%). Of the MAG cohort, 17 055 (48.6%) patients did not receive supplementary SVG (total arterial revascularization). Matching separately generated 22 764 patient pairs for MAG versus single arterial grafting, and 11 137 patient pairs for MAG with total arterial revascularization versus MAG with ≥1 supplementary vein grafts. At a median follow‐up duration of 5.0 years postoperatively, the mortality rate was significantly lower for MAG than single arterial grafting (hazard ratio [HR], 0.79 [95% CI, 0.76–0.83];
P
<0.001). The stratified MAG analysis found that MAG with total arterial revascularization had a lower risk of late death (HR, 0.85 [95% CI, 0.80–0.91];
P
<0.001) compared with MAG with ≥1 supplementary vein grafts. Sensitivity analyses produced consistent outcomes as the primary analysis. Following adjustment for the presence of SVG in the Cox model, the survival advantage of incremental number of arteries was lost.

Conclusions
Multiple arterial grafting has significantly improved long‐term survival compared with single arterial grafting. A further incremental survival benefit exists when no SVG is used.
New Data Concerning the Historical Development of the Frame Tale of the Nights
Authors: Marzolph Ulrich 
Published: November 2023

Abstract
The anonymous thirteenth-century Arabic compilation of wisdom texts, Fiqar al-ḥukamāʾ, contains a hitherto not discussed version of narrative elements that are otherwise known from the frame tale of the Nights, notably both The Thousand and One Nights and its shorter Maghrebi sibling, The Hundred and One Nights. As the Fiqar al-ḥukamāʾ is little known, the present contribution at first introduces the work’s manuscripts and its content before discussing the tale in question.
Fledgling Farms and Failing Health: How the Polypore State Transforms the Multispecies Relations in Serbia’s Raspberry Fields
Authors: Thiemann André 
Published: November 2023

Abstract
Extending from an ethnographic case study that demonstrates the existential troubles of Serbian farmers to continue raspberry production for the global market, this article anthropologically hones in on the intertwining of human and non-human labour (production) with socio-economic and techno-scientific policies of care (reproduction). Different waves of state transformation—the build-up and decay of formal employment coupled with the emergence, then exhaustion of the welfare state, its socio-liberal transformation in the early 2000s, followed by its polypore repurposing for illiberal ends since 2012, have led to a zombified hope in the state’s will to care for its population. Skilled and unskilled workers have emigrated to Western labour markets, while the climate crisis gained momentum because of the underfunding of critical infrastructures of value. Adopting a Marxist-Eco-Feminist care perspective, the case study thus embeds seemingly disconnected concerns within wider struggles on the boundaries of the (welfare) state, economy and techno-science.
Internal Lee Wave Generation from Geostrophic Flow in the Northwestern Pacific Ocean
Authors: Li Ji , Xu Zhenhua , Hao Zhanjiu , You Jia , Zhang Peiwen , Yin Baoshu 
Published: November 2023

Abstract
Among the global mapping of lee wave generation, a missing piece exists in the northwestern Pacific Ocean (NPO), which features complex topographies and energetic circulations. This study applies Bell’s theory to estimate and map internal lee waves generated by geostrophic flows in the NPO using Mercator Ocean reanalysis data and the full topographic spectra obtained from the latest synthetic bathymetry product. Unlike the dominant contributions from abyssal hills in the Southern Ocean, multiple topographies, including ridges, rises, and continental margins, result in an inhomogeneous lee wave generation with multiple hotspots in the NPO. The generation rate is generally higher in the Philippine basin and lower in the central Pacific seamounts. Over ridges, the rough topography creates a high potential for triggering lee waves. Over rises and continental margins, the stronger currents at the shallow depths are favorable for lee wave generation. In the Kuroshio extension region, the rough topography and strong currents cause the strongest lee wave generation, with an energy flux reaching 100 mW m−2. By mean–eddy decomposition, it is found that the lee wave hotspots contributed by mean flow are concentrated in specific regions, while those by geostrophic eddies are widely distributed. Geostrophic eddies are the primary contributor to lee wave generation, which account for 74.6% of the total energy transferred from geostrophic flow to lee waves. This study also reveals that tides suppress the lee wave generation by 14%, and geostrophic flow can cause an asymmetric generation of internal tides.
Utilising routine clinical laboratory data to support quality improvement in health care: Application of a national acute kidney injury alert system as a proof of concept
Authors: Holmes Jennifer , Higginson Ray , Geen John , Phillips Aled 
Published: November 2023

Background Acute kidney injury (AKI) is a global health issue known to cause avoidable harm and death. Improvement in its prevention and management is therefore considered an important goal for the health-care sector. The work here aimed to develop a tool which could be used to robustly and reliably measure, monitor, and compare the effectiveness of health-care interventions related to AKI across the Welsh NHS, a mechanism which did not exist previously. Methods Using serum creatinine (SCr) as a biomarker for AKI and a validated national data-set collected from the all Wales Laboratory Information Management System, work involved applying Donabedian’s framework to develop indicators with which to measure outcomes related to AKI, and exploring the potential of statistical process control (SPC) techniques for analysing data on these indicators. Results Rate of AKI incidence and 30-day AKI-associated mortality are proposed as valid, feasible indicators with which to measure the effectiveness of health-care interventions related to AKI. The control chart, funnel plot, and Pareto chart are proposed as appropriate, robust SPC techniques to analyse and visualise variation in AKI-related outcomes. Conclusions This work demonstrates that routinely collected large SCr data offer a significant opportunity to monitor and therefore inform improvement in patient outcomes related to AKI. Moreover, while this work concerns utilisation of SCr data for improvement in AKI strategies, it is a proof of concept which could be replicated for other routinely collected clinical laboratory data, to improve the prevention and/or management of the conditions to which they relate.
Analysis of factors associated with family disease burden and correlation with social support among family caregivers of patients with severe mental illnesses
Authors: Zhang Xia , Wang Sizhe , Zhao Ran , Zhao Nan , Tao Shilong , Zhang Haiyang , Wu Baiqun , Xia Xiaojuan , Fan Hong 
Published: November 2023

Background: Caregivers are responsible for the home care of family members with severe mental illnesses (SMIs) and their lives are often subject to changes that can create stress and burden. The purpose of this study was to explore the current state of family disease burden and its correlation with social support among family caregivers of SMIs patients. Methods: Using a random sampling method, a total of 1,108 family caregivers of SMIs patients in community health service centers were selected. A general information questionnaire of family caregivers and patients, the Family Disease Burden Scale, and the Social Support Rating Scale were used. Results: The score of the Family Disease Burden Scale of 1108 family caregivers was 16.57 ± 10.65. Family disease burden was negatively correlated with social support ( p < .05). The main influencing factors of family disease burden were average annual family income, duration of illness, distance to medical care, risk of unpredictable behavior, social support, caregiver-patient relationship, gender, and comorbid chronic conditions ( p < .05). Conclusion: Family caregivers of SMIs patients have a relatively low level of caregiver-perceived social support. Interventions to enhance perceived social support could help maintain the health of family caregivers and improve the quality of family care.
Functional neurological disorder in Saudi Arabia: A retrospective study
Authors: Tayeb Haythum O. 
Published: November 2023

Objectives To describe the clinical profile of a sample of Saudi patients with Functional Neurological Disorder (FND). Method A retrospective chart review of FND patients seen from 2021-2023 at a neuropsychiatry clinic at an academic tertiary care center in Jeddah, Saudi Arabia. Results Out of 473 patients seen in the clinic during the review period, 52 (11%) had FND. Mean age was 34 years (standard deviation = 10.7), and 77% were female. Family dispute (39%) was the most reported risk factor, followed by sexual abuse (15%). The most common FND symptoms were nonepileptic seizures (61.5%) and abnormal movements (30.8%). Pain was reported by 57.7% and cognitive symptoms by 36.5%. FND symptoms were frequently attributed to supernatural causes (67.3%). During the last follow-up visit, 53.9% of patients reported FND symptom improvement, whereas 21.2% reported no change, 10.2% reported worsening, and 15% were lost to follow-up. The proportion of patients without symptom improvement was higher among patients with cognitive symptoms (45.5% vs 18% respectively, X2 = 10.08, df = 3, p = .018). The mean number of visits was highest in patients reporting worsening and the lowest was among patients reporting no change (F = 4.21, p = .017). Conclusion The role of family disputes in FND in the Middle East, the role of supernatural concepts in how FND is perceived, and the relatively high rate of subjective improvement within this sample of Saudi FND patients merit further exploration. Cognitive symptoms may be another prognostic indicator. Prospective multicenter studies of those with FND using standardized assessment measures are needed.
Modulation of functional networks related to the serotonin neurotransmitter system by citalopram: Evidence from a multimodal neuroimaging study
Authors: Boucherie Daphne E , Reneman Liesbeth , Booij Jan , Martins Daniel , Dipasquale Ottavia , Schrantee Anouk 
Published: November 2023

Background: Selective serotonin reuptake inhibitors (SSRIs) potentiate serotonergic neurotransmission by blocking the serotonin transporter (5-HTT), but the functional brain response to SSRIs involves neural circuits beyond regions with high 5-HTT expression. Currently, it is unclear whether and how changes in 5-HTT availability after SSRI administration modulate brain function of key serotoninergic circuits, including those characterized by high availability of the serotonin 1A receptor (5-HT1AR). Aim: We investigated the association between 5-HTT availability and 5-HTT- and 5-HT1AR-enriched functional connectivity (FC) after an acute citalopram challenge. Methods: We analyzed multimodal data from a dose–response, placebo-controlled, double-blind study, in which 45 healthy women were randomized into three groups receiving placebo, a low (4 mg), or high (16 mg) oral dose of citalopram. Receptor-Enhanced Analysis of functional Connectivity by Targets was used to estimate 5-HTT- and 5-HT1AR-enriched FC from resting-state and task-based fMRI. 5-HTT availability was determined using [123I]FP-CIT single-photon emission computerized tomography. Results: 5-HTT availability was negatively correlated with resting-state 5-HTT-enriched FC, and with task-dependent 5-HT1AR-enriched FC. Our exploratory analyses revealed lower 5-HT1AR-enriched FC in the low-dose group compared to the high-dose group at rest and the placebo group during the emotional face-matching task. Conclusions: Taken together, our findings provide evidence for differential links between 5-HTT availability and brain function within 5-HTT and 5-HT1AR pathways and in context- and dose-dependent manner. As such, they support a potential pivotal role of the 5-HT1AR in the effects of citalopram on the brain and add to its potential as a therapeutic avenue for mood and anxiety disturbances.
Outcomes After Rotator Cuff Repair With Transverse Scapular Ligament Release in Patients With Severe Fatty Degeneration of the Infraspinatus
Authors: Lee Se Yeon , Kang Dong Mo , Kim Sae Hoon 
Published: November 2023

Background: In some large to massive rotator cuff tears (RCTs), fatty degeneration (FD) is more severe in the infraspinatus than the supraspinatus muscle, and in such cases, suprascapular neuropathy is highly suspected. Nerve release at the suprascapular notch might alleviate this problem. Purpose: To evaluate the effects of the transverse scapular ligament (TSL) release in patients with large to massive RCTs with more severe FD of the infraspinatus than the supraspinatus. Study Design: Cohort study; Level of evidence, 3. Methods: Between September 2017 and January 2022, arthroscopic TSL release with rotator cuff repair was performed in patients with large to massive RCTs and more severe FD of the infraspinatus muscle than the supraspinatus muscle (TSL group). Cuff integrity, FD, and atrophy of cuff muscles were evaluated using preoperative and 1-year postoperative magnetic resonance imaging. In addition, results were compared with those of patients who did not undergo TSL release during arthroscopic large to massive rotator cuff repair (NTSL group). Results: A total of 103 patients—20 in the TSL group and 83 in the NTSL group—were included. Group preoperative characteristics, including tear size and supraspinatus FD, were not significantly different, but infraspinatus FD (TSL vs NTSL; grade, 0-4, 0/0/5/10/5 vs 1/33/42/4/3) and atrophy (grade, 1-3. 3/9/8 vs 56/20/7) differed significantly ( P < .001). Healing failure occurred in 13 of 20 (65%) patients in the TSL group and 30 of 83 (36%) patients in the NTSL group, which was a statistically significant difference ( P = .019). Postoperatively, infraspinatus FD and atrophy were more severe in the TSL group than in the NTSL group ( P < .001), and supraspinatus FD was more severe in the TSL group ( P = .029). Seven patients in the TSL group achieved healing, but FD and atrophy of the supraspinatus and the infraspinatus showed no improvement in this group (all, P > .05). Conclusion: In patients with more FD in the infraspinatus than the supraspinatus muscle, TSL release appeared to have no benefit for cuff healing or FD reversal in cuff muscles. The possibility of suprascapular nerve entrapment remains in patients with more FD in the infraspinatus than the supraspinatus, and this potential nerve problem is not properly addressed by TSL release alone.