bluuebunny/crossref_metadata_2025_split huggingface dataset:
Real-time monitoring polymerization degree of organic photovoltaic materials toward no batch-to-batch variations in device performance
Authors: Xu Lin-Yong , Wang Wei , Yang Xinrong , Wang Shanshan , Shao Yiming , Chen Mingxia , Sun Rui , Min Jie 
Published: February 2024

AbstractPolymerization degree plays a vital role in material properties. Previous methodologies of molecular weight control generally cannot suppress or alleviate batch-to-batch variations in device performance, especially in polymer solar cells. Herein, we develop an in-situ photoluminescence system in tandem with a set of analysis and processing procedures to track and estimate the polymerization degree of organic photovoltaic materials. To support the development of this protocol, we introduce polymer acceptor PYT constructed by near-infrared Y-series small molecule acceptors via Stille polymerization, and shed light on the correlations between molecular weight, spectral parameters, and device efficiencies that enable the design of the optical setup and confirm its feasibility. The universality is verified in PYT derivatives with stereoregularity and fluoro-substitution as well as benzo[1,2-b:4,5-b’]dithiophene-based polymers. Overall, our result provides a tool to tailor suitable conjugated oligomers applied to polymer solar cells and other organic electronics for industrial scalability and desired cost reduction.
Effect of sub-bandgap defects on radiative and non-radiative open-circuit voltage losses in perovskite solar cells
Authors: Aalbers Guus J. W. , van der Pol Tom P. A. , Datta Kunal , Remmerswaal Willemijn H. M. , Wienk Martijn M. , Janssen René A. J. 
Published: February 2024

AbstractThe efficiency of perovskite solar cells is affected by open-circuit voltage losses due to radiative and non-radiative charge recombination. When estimated using sensitive photocurrent measurements that cover the above- and sub-bandgap regions, the radiative open-circuit voltage is often unphysically low. Here we report sensitive photocurrent and electroluminescence spectroscopy to probe radiative recombination at sub-bandgap defects in wide-bandgap mixed-halide lead perovskite solar cells. The radiative ideality factor associated with the optical transitions increases from 1, above and near the bandgap edge, to ~2 at mid-bandgap. Such photon energy-dependent ideality factor corresponds to a many-diode model. The radiative open-circuit voltage limit derived from this many-diode model enables differentiating between radiative and non-radiative voltage losses. The latter are deconvoluted into contributions from the bulk and interfaces via determining the quasi-Fermi level splitting. The experiments show that while sub-bandgap defects do not contribute to radiative voltage loss, they do affect non-radiative voltage losses.
Transient targeting of hypothalamic orexin neurons alleviates seizures in a mouse model of epilepsy
Authors: Li Han-Tao , Viskaitis Paulius , Bracey Eva , Peleg-Raibstein Daria , Burdakov Denis 
Published: February 2024

AbstractLateral hypothalamic (LH) hypocretin/orexin neurons (HONs) control brain-wide electrical excitation. Abnormally high excitation produces epileptic seizures, which affect millions of people and need better treatments. HON population activity spikes from minute to minute, but the role of this in seizures is unknown. Here, we describe correlative and causal links between HON activity spikes and seizures. Applying temporally-targeted HON recordings and optogenetic silencing to a male mouse model of acute epilepsy, we found that pre-seizure HON activity predicts and controls the electrophysiology and behavioral pathology of subsequent seizures. No such links were detected for HON activity during seizures. Having thus defined the time window where HONs influence seizures, we targeted it with LH deep brain stimulation (DBS), which inhibited HON population activity, and produced seizure protection. Collectively, these results uncover a feature of brain activity linked to seizures, and demonstrate a proof-of-concept treatment that controls this feature and alleviates epilepsy.
A nonmetallic plasmonic catalyst for photothermal CO2 flow conversion with high activity, selectivity and durability
Authors: Wan Xueying , Li Yifan , Chen Yihong , Ma Jun , Liu Ying-Ao , Zhao En-Dian , Gu Yadi , Zhao Yilin , Cui Yi , Li Rongtan , Liu Dong , Long Ran , Liew Kim Meow , Xiong Yujie 
Published: February 2024

AbstractThe meticulous design of active sites and light absorbers holds the key to the development of high-performance photothermal catalysts for CO2 hydrogenation. Here, we report a nonmetallic plasmonic catalyst of Mo2N/MoO2-x nanosheets by integrating a localized surface plasmon resonance effect with two distinct types of active sites for CO2 hydrogenation. Leveraging the synergism of dual active sites, H2 and CO2 molecules can be simultaneously adsorbed and activated on N atom and O vacancy, respectively. Meanwhile, the plasmonic effect of this noble-metal-free catalyst signifies its promising ability to convert photon energy into localized heat. Consequently, Mo2N/MoO2-x nanosheets exhibit remarkable photothermal catalytic performance in reverse water-gas shift reaction. Under continuous full-spectrum light irradiation (3 W·cm−2) for a duration of 168 h, the nanosheets achieve a CO yield rate of 355 mmol·gcat−1·h−1 in a flow reactor with a selectivity exceeding 99%. This work offers valuable insights into the precise design of noble-metal-free active sites and the development of plasmonic catalysts for reducing carbon footprints.
Ultralight crystalline hybrid composite material for highly efficient sequestration of radioiodine
Authors: Fajal Sahel , Mandal Writakshi , Torris Arun , Majumder Dipanjan , Let Sumanta , Sen Arunabha , Kanheerampockil Fayis , Shirolkar Mandar M. , Ghosh Sujit K. 
Published: February 2024

AbstractConsidering the importance of sustainable nuclear energy, effective management of radioactive nuclear waste, such as sequestration of radioiodine has inflicted a significant research attention in recent years. Despite the fact that materials have been reported for the adsorption of iodine, development of effective adsorbent with significantly improved segregation properties for widespread practical applications still remain exceedingly difficult due to lack of proper design strategies. Herein, utilizing unique hybridization synthetic strategy, a composite crystalline aerogel material has been fabricated by covalent stepping of an amino-functionalized stable cationic discrete metal-organic polyhedra with dual-pore containing imine-functionalized covalent organic framework. The ultralight hybrid composite exhibits large surface area with hierarchical macro-micro porosity and multifunctional binding sites, which collectively interact with iodine. The developed nano-adsorbent demonstrate ultrahigh vapor and aqueous-phase iodine adsorption capacities of 9.98 g.g−1 and 4.74 g.g−1, respectively, in static conditions with fast adsorption kinetics, high retention efficiency, reusability and recovery.
Separation of benzene and toluene associated with vapochromic behaviors by hybrid[4]arene-based co-crystals
Authors: Chen Jingyu , Zhang Wenjie , Yang Wenzhi , Xi Fengcheng , He Hongyi , Liang Minghao , Dong Qian , Hou Jiawang , Wang Mengbin , Yu Guocan , Zhou Jiong 
Published: February 2024

AbstractThe combination of macrocyclic chemistry with co-crystal engineering has promoted the development of materials with vapochromic behaviors in supramolecular science. Herein, we develop a macrocycle co-crystal based on hybrid[4]arene and 1,2,4,5-tetracyanobenzene that is able to construct vapochromic materials. After the capture of benzene and toluene vapors, activated hybrid[4]arene-based co-crystal forms new structures, accompanied by color changes from brown to yellow. However, when hybrid[4]arene-based co-crystal captures cyclohexane and pyridine, neither structures nor colors change. Interestingly, hybrid[4]arene-based co-crystal can separate benzene from a benzene/cyclohexane equal-volume mixture and allow toluene to be removed from a toluene/ pyridine equal-volume mixture with purities reaching 100%. In addition, the process of adsorptive separation can be visually monitored. The selectivity of benzene from a benzene/cyclohexane equal-volume mixture and toluene from a toluene/ pyridine equal-volume mixture is attributed to the different changes in the charge-transfer interaction between hybrid[4]arene and 1,2,4,5-tetracyanobenzene when hybrid[4]arene-based co-crystal captures different vapors. Moreover, hybrid[4]arene-based co-crystal can be reused without losing selectivity and performance. This work constructs a vapochromic material for hydrocarbon separation.
Disordered regions in proteusin peptides guide post-translational modification by a flavin-dependent RiPP brominase
Authors: Nguyen Nguyet A. , Vidya F. N. U. , Yennawar Neela H. , Wu Hongwei , McShan Andrew C. , Agarwal Vinayak 
Published: February 2024

AbstractTo biosynthesize ribosomally synthesized and post-translationally modified peptides (RiPPs), enzymes recognize and bind to the N-terminal leader region of substrate peptides which enables catalytic modification of the C-terminal core. Our current understanding of RiPP leaders is that they are short and largely unstructured. Proteusins are RiPP precursor peptides that defy this characterization as they possess unusually long leaders. Proteusin peptides have not been structurally characterized, and we possess scant understanding of how these atypical leaders engage with modifying enzymes. Here, we determine the structure of a proteusin peptide which shows that unlike other RiPP leaders, proteusin leaders are preorganized into a rigidly structured region and a smaller intrinsically disordered region. With residue level resolution gained from NMR titration experiments, the intermolecular peptide-protein interactions between proteusin leaders and a flavin-dependent brominase are mapped onto the disordered region, leaving the rigidly structured region of the proteusin leader to be functionally dispensable. Spectroscopic observations are biochemically validated to identify a binding motif in proteusin peptides that is conserved among other RiPP leaders as well. This study provides a structural characterization of the proteusin peptides and extends the paradigm of RiPP modification enzymes using not only unstructured peptides, but also structured proteins as substrates.
A hepatic network of dendritic cells mediates CD4 T cell help outside lymphoid organs
Authors: English Kieran , Kwan Rain , Holz Lauren E. , McGuffog Claire , Krol Jelte M. M. , Kempe Daryan , Kaisho Tsuneyasu , Heath William R. , Lisowski Leszek , Biro Maté , McCaughan Geoffrey W. , Bowen David G. , Bertolino Patrick 
Published: February 2024

AbstractWhile CD4+ T cells are a prerequisite for CD8+ T cell-mediated protection against intracellular hepatotropic pathogens, the mechanisms facilitating the transfer of CD4-help to intrahepatic CD8+ T cells are unknown. Here, we developed an experimental system to investigate cognate CD4+ and CD8+ T cell responses to a model-antigen expressed de novo in hepatocytes and reveal that after initial priming, effector CD4+ and CD8+ T cells migrate into portal tracts and peri-central vein regions of the liver where they cluster with type-1 conventional dendritic cells. These dendritic cells are locally licensed by CD4+ T cells and expand the number of CD8+ T cells in situ, resulting in larger effector and memory CD8+ T cell pools. These findings reveal that CD4+ T cells promote intrahepatic immunity by amplifying the CD8+ T cell response via peripheral licensing of hepatic type-1 conventional dendritic cells and identify intrahepatic perivascular compartments specialized in facilitating effector T cell-dendritic cell interactions.
Structure-guided engineering enables E3 ligase-free and versatile protein ubiquitination via UBE2E1
Authors: Wu Xiangwei , Du Yunxiang , Liang Lu-Jun , Ding Ruichao , Zhang Tianyi , Cai Hongyi , Tian Xiaolin , Pan Man , Liu Lei 
Published: February 2024

AbstractUbiquitination, catalyzed usually by a three-enzyme cascade (E1, E2, E3), regulates various eukaryotic cellular processes. E3 ligases are the most critical components of this catalytic cascade, determining both substrate specificity and polyubiquitination linkage specificity. Here, we reveal the mechanism of a naturally occurring E3-independent ubiquitination reaction of a unique human E2 enzyme UBE2E1 by solving the structure of UBE2E1 in complex with substrate SETDB1-derived peptide. Guided by this peptide sequence-dependent ubiquitination mechanism, we developed an E3-free enzymatic strategy SUE1 (sequence-dependent ubiquitination using UBE2E1) to efficiently generate ubiquitinated proteins with customized ubiquitinated sites, ubiquitin chain linkages and lengths. Notably, this strategy can also be used to generate site-specific branched ubiquitin chains or even NEDD8-modified proteins. Our work not only deepens the understanding of how an E3-free substrate ubiquitination reaction occurs in human cells, but also provides a practical approach for obtaining ubiquitinated proteins to dissect the biochemical functions of ubiquitination.
Observation of giant room-temperature anisotropic magnetoresistance in the topological insulator β-Ag2Te
Authors: Ai Wei , Chen Fuyang , Liu Zhaochao , Yuan Xixi , Zhang Lei , He Yuyu , Dong Xinyue , Fu Huixia , Luo Feng , Deng Mingxun , Wang Ruiqiang , Wu Jinxiong 
Published: February 2024

AbstractAchieving room-temperature high anisotropic magnetoresistance ratios is highly desirable for magnetic sensors with scaled supply voltages and high sensitivities. However, the ratios in heterojunction-free thin films are currently limited to only a few percent at room temperature. Here, we observe a high anisotropic magnetoresistance ratio of −39% and a giant planar Hall effect (520 μΩ⋅cm) at room temperature under 9 T in β-Ag2Te crystals grown by chemical vapor deposition. We propose a theoretical model of anisotropic scattering — induced by a Dirac cone tilt and modulated by intrinsic properties of effective mass and sound velocity — as a possible origin. Moreover, small-size angle sensors with a Wheatstone bridge configuration were fabricated using the synthesized β-Ag2Te crystals. The sensors exhibited high output response (240 mV/V), high angle sensitivity (4.2 mV/V/°) and small angle error (<1°). Our work translates the developments in topological insulators to a broader impact on practical applications such as high-field magnetic and angle sensors.
Phonon thermal transport shaped by strong spin-phonon scattering in a Kitaev material Na2Co2TeO6
Authors: Hong Xiaochen , Gillig Matthias , Yao Weiliang , Janssen Lukas , Kocsis Vilmos , Gass Sebastian , Li Yuan , Wolter Anja U. B. , Büchner Bernd , Hess Christian 
Published: February 2024

AbstractThe report of a half-quantized thermal Hall effect and oscillatory structures in the magnetothermal conductivity in the Kitaev material α-RuCl3 have sparked a strong debate on whether it is generated by Majorana fermion edge currents, spinon Fermi surface, or whether other more conventional mechanisms are at its origin. Here, we report low temperature thermal conductivity (κ) of another candidate Kitaev material, Na2Co2TeO6. The application of a magnetic field (B) along different principal axes of the crystal reveals a strong directional-dependent B impact on κ, while no evidence for mobile quasiparticles except phonons can be concluded at any field. Instead, severely scattered phonon transport prevails across the B−T phase diagram, revealing cascades of phase transitions for all B directions. Our results thus cast doubt on recent proposals for significant itinerant magnetic excitations in Na2Co2TeO6, and emphasize the importance of discriminating true spin liquid transport properties from scattered phonons in candidate materials.
Fluorescent Neuronal Cells v2: multi-task, multi-format annotations for deep learning in microscopy
Authors: Clissa Luca , Macaluso Antonio , Morelli Roberto , Occhinegro Alessandra , Piscitiello Emiliana , Taddei Ludovico , Luppi Marco , Amici Roberto , Cerri Matteo , Hitrec Timna , Rinaldi Lorenzo , Zoccoli Antonio 
Published: February 2024

AbstractFluorescent Neuronal Cells v2 is a collection of fluorescence microscopy images and the corresponding ground-truth annotations, designed to foster innovative research in the domains of Life Sciences and Deep Learning. This dataset encompasses three image collections wherein rodent neuronal cell nuclei and cytoplasm are stained with diverse markers to highlight their anatomical or functional characteristics. Specifically, we release 1874 high-resolution images alongside 750 corresponding ground-truth annotations for several learning tasks, including semantic segmentation, object detection and counting. The contribution is two-fold. First, thanks to the variety of annotations and their accessible formats, we anticipate our work will facilitate methodological advancements in computer vision approaches for segmentation, detection, feature extraction, unsupervised and self-supervised learning, transfer learning, and related areas. Second, by enabling extensive exploration and benchmarking, we hope Fluorescent Neuronal Cells v2 will catalyze breakthroughs in fluorescence microscopy analysis and promote cutting-edge discoveries in life sciences.
A 10-m annual grazing intensity dataset in 2015–2021 for the largest temperate meadow steppe in China
Authors: Chang Chuchen , Wang Jie , Zhao Yanbo , Cai Tianyu , Yang Jilin , Zhang Geli , Wu Xiaocui , Otgonbayar Munkhdulam , Xiao Xiangming , Xin Xiaoping , Zhang Yingjun 
Published: February 2024

AbstractMapping grazing intensity (GI) using satellites is crucial for developing adaptive utilization strategies according to grassland conditions. Here we developed a monitoring framework based on a paired sampling strategy and the classification probability of random forest algorithm to produce annual grazing probability (GP) and GI maps at 10-m spatial resolution from 2015 to 2021 for the largest temperate meadow in China (Hulun Buir grasslands), by harmonized Landsat 7/8 and Sentinel-2 images. The GP maps used values of 0–1 to present detailed grazing gradient information. To match widely used grazing gradients, annual GI maps with ungrazed, moderately grazed, and heavily grazed levels were generated from the GP dataset with a decision tree. The GI maps for 2015–2021 had an overall accuracy of more than 0.97 having significant correlations with the statistical data at city (r = 0.51) and county (r = 0.75) scales. They also effectively captured the GI gradients at site scale (r = 0.94). Our study proposed a monitoring approach and presented annual 10-m grazing information maps for sustainable grassland management.
Chromosome-scale genome assembly of Lepus oiostolus (Lepus, Leporidae)
Authors: Feng Shuo , Zhang Yaying , He Zhaotong , Xi Erning , Ru Dafu , Liang Jian , Yang Yongzhi 
Published: February 2024

AbstractLepus oiostolus (L. oiostolus) is a species endemic to the Qinghai-Tibet Plateau. However, the absence of a reference genome limits genetic studies. Here, we reported a high-quality L. oiostolus genome assembly, with scaffolds anchored to 24 chromosomes and a total assembled length of 2.80 Gb (contig N50 = 64.25 Mb). Genomic annotation uncovered 22,295 protein-coding genes and identified 49.84% of the sequences as transposable elements. Long interspersed nuclear elements (LINEs) constitute a high proportion of the genome. Our study is at the first time to report the chromosome-scale genome for the species of the L. oiostolus. It provides a valuable genomic resource for future research on the evolution of the Leporidae.
Bayesian network approach for reliability analysis of mining trucks
Authors: Rahimdel Mohammad Javad 
Published: February 2024

AbstractHaving a safe and efficient system for mineral transportation is a top priority for all mining operations. Trucks are the most widely used material transportation systems that are applied in both surface and underground mines. Any truck failure disrupts the mineral transportation process and consequently decreases the overall output. Therefore, the reliability analysis of such equipment plays a critical role in increasing the efficiency and productivity of a mining operation. This paper proposes a novel method for analyzing the reliability of a fleet of mining trucks based on the Bayesian Network modeling. Considering the reliability block diagram, the fault tree of trucks was developed according to the logical relationship between the units. Then, a dynamic Bayesian network was constructed according to the conditional probability analysis. Moreover, the relative contributions of each truck’s component to the occurrence of the fleet failure were studied by using critical analysis. The results of this paper show that the successful operation of the fleet of trucks is most sensitive to truck no. 5, which has the highest reliability level in all time intervals. The reliability of the fleet of trucks reaches 0.881 at 20 h, and the fuel injection system of the truck’s engine is the main leading cause of the trucks failure. A proper preventive maintenance strategy should be paid more attention to improve the reliability and availability of the engine system.
Effect of apricot kernel seed extract on biophysical properties of chitosan film for packaging applications
Authors: Saied Mona , Ward Azza , Hamieda Shimaa Farag 
Published: February 2024

AbstractChitosan is a natural biodegradable biopolymer that has drawbacks in mechanical and antibacterial properties, limiting its usage in biological and medicinal fields. Chitosan is combined with other naturally occurring substances possessing biological antibacterial qualities in order to broaden its application. Ethanolic apricot kernel seed extract was prepared, analyzed, and incorporated into chitosan film with different concentrations (0.25, 0.5, and 0.75 wt%). Furthermore, the effect of AKSE and γ-radiation (20 Gy and 20 kGy) on the physical properties of the film was studied. The prepared films were characterized by Fourier transform infrared spectroscopy (FTIR), which revealed that AKSE did not cause any change in the molecular structure, whereas the γ-irradiation dose caused a decrease in the peak intensity of all concentrations except 0.75 wt%, which was the most resistant. In addition, their dielectric, optical, and antimicrobial properties were studied. Also, AKSE-enhanced optical qualities, allowed them to fully block light transmission at wavelengths of 450–600 nm. The dielectric properties, i.e., permittivity (ε′), dielectric loss (ε′′), and electrical conductivity (σ), increased with increasing AKSE concentration and film irradiation. The antimicrobial studies revealed that the antimicrobial activity against Escherichia coli and Canodida albicans increased with AKSE incorporation.