bluuebunny/crossref_metadata_2025_split huggingface dataset:
Участь засобів масової інформації у запобіганні злочинності в умовах воєнного стану в Україні (на прикладі міста Ірпінь Київської області)
Authors: Бодунова O. , Яцик т , Лугіна Н. 
Published: December 2023

У науковій статті розглядаються основні принципи взаємодії ЗМІ з правоохо­ронними органами в Україні в умовах воєнного стану. Зазначається, що з 24 лютого 2022 року російські окупанти ведуть активну інформаційну війну, крім активних бойових дій, розстрілів мирних жителів, агресивного руйнування будинків та розкрадання майна. Вона проявляється у використанні фейкових профілів у соціальних мережах для отримання інформації про дислокацію Збройних сил України, терито­ріальну оборону та дезінформації цивільного населення, надання українцям неправдивої інформації з метою їх повернення у зону активних бойових дій. Відмічено, що окупантами була проведена активна інформаційна атака на національні ЗМІ з метою припинення поширення інформації про російську агресію та вбивства мирних жителів.
Зазначено, що під взаємодією правоохоронних органів і ЗМІ варто розуміти своєрідні відносини між пресслужбами правоохоронних органів і ЗМІ, в результаті яких вони доповнюють результати один одного, створюючи основу для більш ефективної роботи кожної зі сторін. Виокремлено напрями взаємодії ЗМІ з правоохоронними органами в Україні в умовах воєнного стану.
Враховуючи норми законодавства та суспільно-політичні реалії, що склалися в Україні, надано рекомендації щодо взаємодії правоохоронних органів із ЗМІ: 1) ухвалення окремого нормативно-правового акта, який би визначав основні принципи взаємодії правоохоронних органів із ЗМІ; обов’язки сторін, зокрема журналістів, поради та рекомендації щодо належного інформування громадськості про події, що відбуваються в Україні; 2) співпраця правоохоронних органів із засобами масової інформації має базуватися насамперед на засадах забезпечення безпеки осіб, а вже потім – на своєчасному інформуванні громадськості про події; 3) правоохоронним органам необхідно звернути особливу увагу на журналістів, які працюють у сфері забезпечення міжнародних стандартів, щоб вони у належний спосіб доносили інформацію як до цивільного населення, так і до міжнародної спільноти.
Pelatihan Microsoft Office Dan Internet Trouble Shooting dalam Meningkatkan Pengetahuan Teknologi Informasi Pada Staff Sekretariat Daerah Pemerintah Kabupaten Bengkulu Tengah
Authors: Tiara Eka Putri  , Ferzha Putra Utama  , Nurul Renaningtias  
Published: December 2023

Kegiatan pada Sekretariat Daerah Kabupaten Bengkulu Tengah sudah mulai terdigitalisasi dan online. Sebagai pendukung sarana dalam bekerja, pegawai Pemerintah Daerah Kabupaten Bengkulu Tengah dituntut menguasai Microsoft Office dan Internet Troubleshooting. Kondisi saat ini, kemampuan Staff Sekretariat daerah masih dikatakan kurang atau masih pada kemampuan dasar. Keterbatasan pengetahuan tersebut dikarenakan belum adanya pelatihan yang memadai terhadap Staff Sekretariat Daerah Pemerintah Kabupaten Bengkulu Tengah. Sehingga pelayanan kepada masyarakat dan pembuatan laporan atau surat menyurat memerlukan waktu yang lumanyan lama. Oleh karena itu, Pelatihan Microsoft Office dan Internet Troubleshooting perlu diberlakukan untuk menunjang kinerja pengawai pada Staff Sekretariat Daerah Pemerintah Kabupaten Bengkulu Tengah. Metode yang dilakukan dalam pengabdian ini adalah dengan melakukan pendampingan praktik langsung kepada peserta. Pengukuran atas pemahaman terkait dengan materi yang disampaikan akan dilakukan dengan menggunakan kuesioner online. Khalayak sasaran pada pengabdian ini adalah 22 orang Perwakilan Staff Sekretariat Daerah Pemerintah Kabupaten Bengkulu Tengah.
Penerapan Budidaya Cabai Dengan Sistem Tanam Kombinasi Pada Kelompok Wanita Tani Anggrek Pematang Gubernur Kota Bengkulu
Authors: Herawati Reny , Ganefianti Dwi Wahyuni , Romeida Atra 
Published: December 2023

Penggunaan lahan pertanian penduduk sebagian besar digunakan untuk persawahan dan kebun untuk kebutuhan keluarga yang ditanam sayuran seperti cabai tomat, terong, dan lain-lain. Teknik budidaya cabai yang dilakukan masih sangat tradisional dan didominasi oleh serangan hama dan penyakit sehingga produktivitasnya sangat rendah. Oleh karena itu perlu dilakukan pembinaan bagaimana mengoptimalkan pemanfaatan lahan pekarangan maupun kebun dengan teknologi budidaya cabai dengan sistem tanam kombinasi. Kegiatan pengabdian masyarakat dengan topik “Penerapan Budidaya Cabai dengan Sistem Tanam Kombinasi” dilaksanakan di Kelompok Tani Wanita Anggrek, Kelurahan Pematang Gubernur, pada bulan Agustus-November 2022. Penerapan budidaya cabai diterapkan di kebun masyarakat sebagai damplot KWT Anggrek Pematang Gubernur. Pelaksanaan kegiatan melibatkan mahasiswa Program Studi Agroekoteknologi sebagai bentuk pembelajaran dalam transfer teknologi kepada masyarakat sebelum mereka terjun langsung ke masyarakat dalam melaksanakan program KKN. Metode pengabdian dalam bentuk penyuluhan menyampaikan topik materi dan dilanjutkan dengan tanya jawab dan demplot di kebun masyarakat setempat. Penyampaian materi mulai dari pembibitan sampai panen. Kemudian dilanjutkan dengan membuat damplot dan peragaan cara menanam cabai dengan teknologi kombinasi beberapa varietas hibrida. Wawasan dan pengetahuan ibu-ibu KWT Anggrek semakin luas dari kegiatan pengabdian masyarakat tentang budidaya cabai dengan sistem tanam kombinasi, sehingga dapat mengurangi serangan hama dan penyakit, mengurangi penggunaan pestisida. Hasil panen dapat dimanfaatkan untuk menambah pendapatan keluarga dan mengurangi biaya bumbu dapur untuk kebutuhan sehari-hari, bahkan dari hasilnya dapat menambah income keluarga. Untuk dapat berwirausaha secara mandiri diperlukan arahan secara kontinyu terutama bimbingan dalam mengolah hasil panen dengan berbagai macam olahan yang bernilai ekonomi dan dapat dipasarkan dengan jangkauan lebih luas.
Inflammatory Status of Monocytes in Type 2 Diabetes Mellitus
Authors: Kirichenko T. V. , Bochkareva L. A. , Nedosugova L. V. , Markina Yu. V. , Kuzina I. A. , Petunina N. A. , Tolstik T. V. , Bogatyreva A. I. , Antonov V. A. , Markin A. M. 
Published: December 2023

Сhronic inflammation is considered as a key factor in the development of type 2 diabetes mellitus. Impaired tolerance of the inflammatory response of monocytes is regarded as an important mechanism in the pathogenesis of chronic inflammation. In this work, we study the inflammatory activation and tolerance of the immune response of monocytes in diabetes. In total, 40 patients with newly diagnosed diabetes and 40 control group participants were included in the study. The level of basal, LPS-stimulated and re-stimulated secretion of the TNF-α, IL-1β, and MCP-1 cytokines was assessed in a monocyte culture isolated from the blood by immunomagnetic separation of CD14+ cells. The level of basal, LPS-stimulated and re-stimulated TNF-α secretion was significantly higher in patients with diabetes; the level of IL-1β secretion did not differ significantly between the groups; basal and re-stimulated MCP-1 secretion was also significantly higher in the diabetes group. Re-stimulated secretion of TNF-α and IL-1β was reduced compared to primary-stimulated secretion in both groups, demonstrating the tolerance of the macrophage immune response to these cytokines. Re-stimulated secretion of MCP-1 in 42% of diabetes patients was higher than primary stimulated secretion, thus revealing an impaired tolerance of the immune response of macrophages. A correlation was found between TNF-α secretion and body mass index, r=0.631, p<0.001, and with glycemic level, r=0.427, p=0.037. The results obtained demonstrate inflammatory activation of monocytes with hypersecretion of TNF-α and MCP-1, impaired tolerance of the immune response of monocytes in diabetes regarding the secretion of MCP-1, as well as a correlation of TNF-α secretion with body mass index and glycemic level. This indicates an important role of TNF-α and MCP-1 in the pathogenesis of chronic inflammation in type 2 diabetes, thus allowing these cytokines to be considered as potential therapeutic targets for pathogenetic therapy of type 2 diabetes.
Phase characteristics of vocal tract filter can distinguish speakers
Authors: Okada Masahiro , Ito Hiroshi 
Published: December 2023

IntroductionSpeaker recognition has been performed by considering individual variations in the power spectrograms of speech, which reflect the resonance phenomena in the speaker's vocal tract filter. In recent years, phase-based features have been used for speaker recognition. However, the phase-based features are not in a raw form of the phase but are crafted by humans, suggesting that the role of the raw phase is less interpretable. This study used phase spectrograms, which are calculated by subtracting the phase in the time-frequency domain of the electroglottograph signal from that of speech. The phase spectrograms represent the non-modified phase characteristics of the vocal tract filter.MethodsThe phase spectrograms were obtained from five Japanese participants. Phase spectrograms corresponding to vowels, called phase spectra, were then extracted and circular-averaged for each vowel. The speakers were determined based on the degree of similarity of the averaged spectra.ResultsThe accuracy of discriminating speakers using the averaged phase spectra was observed to be high although speakers were discriminated using only phase information without power. In particular, the averaged phase spectra showed different shapes for different speakers, resulting in the similarity between the different speaker spectrum pairs being lower. Therefore, the speakers were distinguished by using phase spectra.DiscussionThis predominance of phase spectra suggested that the phase characteristics of the vocal tract filter reflect the individuality of speakers.
Chemical contributions to silicon anode calendar aging are dominant over mechanical contributions
Authors: McBrayer Josefine D. , Harrison Katharine L. , Allcorn Eric , Minteer Shelley D. 
Published: December 2023

Silicon (Si) anodes are a promising candidate for increasing the energy density of lithium (Li)-ion batteries for electric vehicles. However, they have recently been identified as having poor calendar life that is insufficient for commercial needs, in addition to the well-known issue of their poor cycle life resulting from large volume expansion. Here, a specially designed protocol with variable rest periods between intermittent cycling is used to evaluate the impact of the mechanical disruption of Si and solid electrolyte interphase (SEI) from cycling on calendar aging measurements. Si was found to undergo more mechanical degradation during calendar aging with intermittent cycling than graphite. However, Si anode capacity fade was still dominated by time, especially for rest periods greater than or equal to 1 month between cycling. Postmortem dQ/dV half-cell analysis indicated this was mainly due to Li inventory loss and an increase in electrode resistance. Isothermal microcalorimetry further demonstrated that Si passivation is more disrupted than graphite passivation with intermittent cycling and suggested that there may be a chemical buildup of a detrimental species in the electrolyte, leading to a large spike in heat after the Si and SEI are disrupted by cycling.
Multi-dimension metabolic prognostic model for gastric cancer
Authors: Feng Wanjing , Xu Bei , Zhu Xiaodong 
Published: December 2023

BackgroundMetabolic reprogramming is involved in different stages of tumorigenesis. There are six widely recognized tumor-associated metabolic pathways, including cholesterol catabolism process, fatty acid metabolism, glutamine metabolic process, glycolysis, one carbon metabolic process, and pentose phosphate process. This study aimed to classify gastric cancer patients into different metabolic bio-similar clusters.MethodWe analyzed six tumor-associated metabolic pathways and calculated the metabolic pathway score through RNA-seq data using single sample gene set enrichment analysis. The consensus clustering analysis was performed to classify patients into different bio-similar clusters by multi-dimensional scaling. Kaplan–Meier curves were presented between different metabolic bio-similar groups for OS analysis.ResultsA training set of 370 patients from the Cancer Genome Atlas database with primary gastric cancer was chosen. Patients were classified into four metabolic bio-similar clusters, which were identified as metabolic non-specificity, metabolic-active, cholesterol-silence, and metabolic-silence clusters. Survival analysis showed that patients in metabolic-active cluster and metabolic-silence cluster have significantly poor prognosis than other patients (p=0.031). Patients in metabolic-active cluster and metabolic-silence cluster had significantly higher intra-tumor heterogeneity than other patients (p=0.032). Further analysis was performed in metabolic-active cluster and cholesterol-silence cluster. Three cell-cycle-related pathways, including G2M checkpoints, E2F targets, and MYC targets, were significantly upregulated in metabolic-active cluster than in cholesterol-silence cluster. A validation set of 192 gastric cancer patients from the Gene Expression Omnibus data portal verified that metabolic bio-similar cluster can predict prognosis in gastric cancer.ConclusionOur study established a multi-dimension metabolic prognostic model in gastric cancer, which may be feasible for predicting clinical outcome.
Bioinformatics-led discovery of liver-specific genes and macrophage infiltration in acute liver injury
Authors: Cao Zhiwen , Lu Peipei , Li Li , Geng Qi , Lin Lin , Yan Lan , Zhang Lulu , Shi Changqi , Li Li , Zhao Ning , He Xiaojuan , Tan Yong , Lu Cheng 
Published: December 2023

BackgroundAcute liver injury (ALI) is an important global health concern, primarily caused by widespread hepatocyte cell death, coupled with a complex immune response and a lack of effective remedies. This study explores the underlying mechanisms, immune infiltration patterns, and potential targets for intervention and treatment ALI.MethodsThe datasets of acetaminophen (APAP), carbon tetrachloride (CCl4), and lipopolysaccharide (LPS)-induced ALI were obtained from the GEO database. Differentially expressed genes (DEGs) were individually identified using the limma packages. Functional enrichment analysis was performed using KEGG, GO, and GSEA methods. The overlapping genes were extracted from the three datasets, and hub genes were identified using MCODE and CytoHubba algorithms. Additionally, PPI networks were constructed based on the String database. Immune cell infiltration analysis was conducted using ImmuCellAI, and the correlation between hub genes and immune cells was determined using the Spearman method. The relationship between hub genes, immune cells, and biochemical indicators of liver function (ALT, AST) was validated using APAP and triptolide (TP) -induced ALI mouse models.ResultsFunctional enrichment analysis indicated that all three ALI models were enriched in pathways linked to fatty acid metabolism, drug metabolism, inflammatory response, and immune regulation. Immune analysis revealed a significant rise in macrophage infiltration. A total of 79 overlapping genes were obtained, and 10 hub genes were identified that were consistent with the results of the biological information analysis after screening and validation. Among them, Clec4n, Ms4a6d, and Lilrb4 exhibited strong associations with macrophage infiltration and ALI.
Research trends and hotspots of post-stroke dysphagia rehabilitation: a bibliometric study and visualization analysis
Authors: He Yuanyuan , Tan Xuezeng , Kang Huiqi , Wang Huan , Xie Yuyao , Zheng Dongxiang , Li Chen 
Published: December 2023

BackgroundPost-stroke dysphagia (PSD) is one of the most prevalent stroke sequelae, affecting stroke patients’ prognosis, rehabilitation results, and quality of life while posing a significant cost burden. Although studies have been undertaken to characterize the pathophysiology, epidemiology, and risk factors of post-stroke dysphagia, there is still a paucity of research trends and hotspots on this subject. The purpose of this study was to create a visual knowledge map based on bibliometric analysis that identifies research hotspots and predicts future research trends.MethodsWe searched the Web of Science Core Collection for material on PSD rehabilitation research from its inception until July 27, 2023. We used CiteSpace, VOSviewer, and Bibliometrix R software packages to evaluate the annual number of publications, nations, institutions, journals, authors, references, and keywords to describe present research hotspots and prospective research orientations.ResultsThis analysis comprised 1,097 articles from 3,706 institutions, 374 journals, and 239 countries or regions. The United States had the most publications (215 articles), and it is the most influential country on the subject. “Dysphagia” was the most published journal (100 articles) and the most referenced journal (4,606 citations). Highly cited references focused on the pathophysiology and neuroplasticity mechanisms of PSD, therapeutic modalities, rehabilitation tactics, and complications prevention. There was a strong correlation between the terms “validity” and “noninvasive,” which were the strongest terms in PSD rehabilitation research. The most significant words in PSD rehabilitation research were “validity” and “noninvasive brain stimulation,” which are considered two of the most relevant hotspots in the field.ConclusionWe reviewed the research in the field of PSD rehabilitation using bibliometrics to identify research hotspots and cutting-edge trends in the field, primarily including the pathogenesis and neurological plasticity mechanisms of PSD, complications, swallowing screening and assessment methods, and swallowing rehabilitation modalities, and this paper can provide in the follow-up research in the field of PSD rehabilitation. The results of this study can provide insightful data for subsequent studies in the field of PSD rehabilitation.
Children with developmental coordination disorder have less variable motor unit firing rate characteristics across contractions compared to typically developing children
Authors: Esselaar Maaike , Parr Johnny V. V. , Wood Greg , Hodson-Tole Emma 
Published: December 2023

IntroductionUnderstanding the nuances of neuromuscular control is crucial in unravelling the complexities of developmental coordination disorder (DCD), which has been associated with differences in skeletal muscle activity, implying that children with DCD employ distinct strategies for muscle control. However, force generation and control are dependent on both recruitment of motor units and their firing rates and these fine details of motor function have yet to be studied in DCD. The purpose of this study was therefore to compare motor unit characteristics in a small muscle of the hand during low level, handgrip contractions in typically developing (TD) children and children with DCD.MethodsEighteen children (9 TD vs. 9 DCD) completed a series of manual handgrip contractions at 10 ± 5% of their maximum voluntary contraction. High density surface electromyography was used to record excitation of the first dorsal interosseus muscle. Recorded signals were subsequently decomposed into individual motor unit action potential trains. Motor unit characteristics (firing rate, inter-pulse interval, and action potential amplitude) were analysed for contractions that had a coefficient variation of &lt;10%.Results and DiscussionThis study found few differences in average motor unit characteristics (number of motor units: TD 20.24 ± 9.73, DCD 27.32 ± 14.00; firing rate: TD 7.74 ± 2.16 p.p.s., DCD 7.86 ± 2.39 p.p.s.; inter-pulse interval: TD 199.72 ± 84.24 ms, DCD 207.12 ± 103 ms) when force steadiness was controlled for, despite the DCD group being significantly older (10.89 ± 0.78 years) than the TD group (9.44 ± 1.67 years). However, differences were found in the variability of motor unit firing statistics, with the children with DCD surprisingly showing less variability across contractions (standard deviation of coefficient of variation of inter-pulse interval: TD 0.38 ± 0.12, DCD 0.28 ± 0.11). This may suggest a more fixed strategy to stabilise force between contractions used by children with DCD. However, as variability of motor unit firing has not been considered in previous studies of children further work is required to better understand the role of variability in motor unit firing during manual grasping tasks, in all children.
Practical considerations of diffusion-weighted MRS with ultra-strong diffusion gradients
Authors: Davies-Jenkins Christopher W. , Döring André , Fasano Fabrizio , Kleban Elena , Mueller Lars , Evans C. John , Afzali Maryam , Jones Derek K. , Ronen Itamar , Branzoli Francesca , Tax Chantal M. W. 
Published: December 2023

IntroductionDiffusion-weighted magnetic resonance spectroscopy (DW-MRS) offers improved cellular specificity to microstructure—compared to water-based methods alone—but spatial resolution and SNR is severely reduced and slow-diffusing metabolites necessitate higher b-values to accurately characterize their diffusion properties. Ultra-strong gradients allow access to higher b-values per-unit time, higher SNR for a given b-value, and shorter diffusion times, but introduce additional challenges such as eddy-current artefacts, gradient non-uniformity, and mechanical vibrations.MethodsIn this work, we present initial DW-MRS data acquired on a 3T Siemens Connectom scanner equipped with ultra-strong (300 mT/m) gradients. We explore the practical issues associated with this manner of acquisition, the steps that may be taken to mitigate their impact on the data, and the potential benefits of ultra-strong gradients for DW-MRS. An in-house DW-PRESS sequence and data processing pipeline were developed to mitigate the impact of these confounds. The interaction of TE, b-value, and maximum gradient amplitude was investigated using simulations and pilot data, whereby maximum gradient amplitude was restricted. Furthermore, two DW-MRS voxels in grey and white matter were acquired using ultra-strong gradients and high b-values.ResultsSimulations suggest T2-based SNR gains that are experimentally confirmed. Ultra-strong gradient acquisitions exhibit similar artefact profiles to those of lower gradient amplitude, suggesting adequate performance of artefact mitigation strategies. Gradient field non-uniformity influenced ADC estimates by up to 4% when left uncorrected. ADC and Kurtosis estimates for tNAA, tCho, and tCr align with previously published literature.DiscussionIn conclusion, we successfully implemented acquisition and data processing strategies for ultra-strong gradient DW-MRS and results indicate that confounding effects of the strong gradient system can be ameliorated, while achieving shorter diffusion times and improved metabolite SNR.