bluuebunny/crossref_metadata_2025_split huggingface dataset:
1,25‐Dihydroxyvitamin D3 potentiates the innate immune response of peripheral blood mononuclear cells from Japanese Black cattle
Authors: Oyamada Youki , Iizasa Ei'ichi , Usa Amane , Otomaru Konosuke 
Published: December 2023

Abstract1,25‐Dihydroxyvitamin D3 (1,25(OH)2D3), a bioactive vitamin D, is known to regulate immune responses in mammals. However, its impact on the innate immune responses of Japanese Black cattle, which are beef cattle endemic to Japan, remains unknown. Thus, in this study, we investigated the effect of 1,25(OH)2D3 on the immune responses of peripheral blood mononuclear cells from Japanese Black cattle. As a result, the treatment of 1,25(OH)2D3 upregulated the expression of antibacterial peptides, bovine beta‐defensin 10 (DEFB10), and lingual antimicrobial peptide (LAP), in the presence and absence of lipopolysaccharide (LPS) stimulation. Moreover, 1,25(OH)2D3 enhanced the inflammatory responses, including C‐X‐C motif ligand 8 (CXCL8) and nitric oxide synthase (NOS2), while reducing the expression of anti‐inflammatory cytokine IL10, leading to an inflammatory phenotype. However, in contrast to humans and mice, 1,25(OH)2D3 did not alter the expression of tumor necrosis factor (TNF) and downregulated triggering receptor expressed on myeloid cell 1 (TREM1) with LPS treatment. These results suggest that 1,25(OH)2D3 potentiates the innate immune responses of Japanese Black cattle, albeit with different effects and mechanisms as compared to humans and mice.
Effects of starch content of calf starter on feed intake, growth performance, and fecal properties in dairy calves under a high plane of milk replacer feeding
Authors: Satoh Hitomi , Fukumori Rika , Osada Takehiko , Shimada Kensuke , Oikawa Shin , Izumi Kenichi 
Published: December 2023

AbstractThe objective of this study was to investigate the effects of different starch contents in calf starter on the growth, feed intake, and fecal characteristics in dairy calves fed under a high plane of nutrition. Twenty‐seven Holstein calves were assigned equally to one of three calf starter treatment groups in a randomized block design: high (H) starch (41.8%); medium (M) starch (31.9%); and low (L) starch (22.0%). Milk replacer was fed up to 1.2 kg/day as fed, gradually reduced from 6 weeks of age; calves were weaned at 8 weeks of age. Each starter (up to 3.5 kg/day as fed) and chopped hay were provided ad libitum from 5 days of age. Fecal samples, along with body measurements, were collected from 4 to 13 weeks of age. The average daily gain after weaning was greater in the H group than in the L group. The average starter intake for 3 days before weaning was not different among treatments but was greater after weaning in the H group than in the L group. Starter starch content did not affect the number of days with diarrhea or fecal starch concentration. The high‐starch starter had no adverse effects during the weaning transition.
Predicting treatment response using machine learning: A registered report
Authors: Jankowsky Kristin , Krakau Lina , Schroeders Ulrich , Zwerenz Rüdiger , Beutel Manfred E. 
Published: December 2023

AbstractObjectivePrevious research on psychotherapy treatment response has mainly focused on outpatients or clinical trial data which may have low ecological validity regarding naturalistic inpatient samples. To reduce treatment failures by proactively screening for patients at risk of low treatment response, gain more knowledge about risk factors and to evaluate treatments, accurate insights about predictors of treatment response in naturalistic inpatient samples are needed.MethodsWe compared the performance of different machine learning algorithms in predicting treatment response, operationalized as a substantial reduction in symptom severity as expressed in the Patient Health Questionnaire Anxiety and Depression Scale. To achieve this goal, we used different sets of variables—(a) demographics, (b) physical indicators, (c) psychological indicators and (d) treatment‐related variables—in a naturalistic inpatient sample (N = 723) to specify their joint and unique contribution to treatment success.ResultsThere was a strong link between symptom severity at baseline and post‐treatment (R2 = .32). When using all available variables, both machine learning algorithms outperformed the linear regressions and led to an increment in predictive performance of R2 = .12. Treatment‐related variables were the most predictive, followed psychological indicators. Physical indicators and demographics were negligible.ConclusionsTreatment response in naturalistic inpatient settings can be predicted to a considerable degree by using baseline indicators. Regularization via machine learning algorithms leads to higher predictive performances as opposed to including nonlinear and interaction effects. Heterogenous aspects of mental health have incremental predictive value and should be considered as prognostic markers when modelling treatment processes.
T‐cell redirection therapy after allogeneic stem cell transplantation in multiple myeloma: When the cure fails!
Authors: Richter Joshua 
Published: December 2023

Allogeneic stem cell transplant remains an option for patients with myeloma. Given the unfortunate inevitability of the majority of patients, relapsing salvage therapy options are needed. Although there is a potential concern for subsequent T‐cell redirection therapy in these patients, Hammons et al. provide a retrospective look at patients treated this way with no new significant adverse safety or efficacy signal.Commentary on: Hammons et al. Chimeric antigen receptor and bispecific T‐cell engager therapies in multiple myeloma patients with prior allogeneic transplantation. Br J Haematol 2024;204:887‐891.
A novel role for microtubule affinity‐regulating kinases in neuropathic pain
Authors: Shi Yao‐Qin , Sun Zhi‐Hong , Wang Zhe‐Zhe , Su Chun‐Yu , Zhang Wei , Yu Lin‐Yao , Xu Yang , Gao Yong‐Lin , Wang Hong‐Bo , Tian Jing‐Wei , Li Chun‐Mei 
Published: December 2023

AbstractBackground and PurposeNeuropathic pain affects millions of patients, but there are currently few viable therapeutic options available. Microtubule affinity‐regulating kinases (MARKs) regulate the dynamics of microtubules and participate in synaptic remodelling. It is unclear whether these changes are involved in the central sensitization of neuropathic pain. This study examined the role of MARK1 or MARK2 in regulating neurosynaptic plasticity induced by neuropathic pain.Experimental ApproachA rat spinal nerve ligation (SNL) model was established to induce neuropathic pain. The role of MARKs in nociceptive regulation was assessed by genetically knocking down MARK1 or MARK2 in amygdala and systemic administration of PCC0105003, a novel small molecule MARK inhibitor. Cognitive function, anxiety‐like behaviours and motor coordination capability were also examined in SNL rats. Synaptic remodelling‐associated signalling changes were detected with electrophysiological recording, Golgi‐Cox staining, western blotting and qRT‐PCR.Key ResultsMARK1 and MARK2 expression levels in amygdala and spinal dorsal horn were elevated in SNL rats. MARK1 or MARK2 knockdown in amygdala and PCC0105003 treatment partially attenuated pain‐like behaviours along with improving cognitive deficit, anxiogenic‐like behaviours and motor coordination in SNL rats. Inhibition of MARKs signalling reversed synaptic plasticity at the functional and structural levels by suppressing NR2B/GluR1 and EB3/Drebrin signalling pathways both in amygdala and spinal dorsal horn.Conclusion and ImplicationsThese results suggest that MARKs‐mediated synaptic remodelling plays a key role in the pathogenesis of neuropathic pain and that pharmacological inhibitors of MARKs such as PCC0105003 could represent a novel therapeutic strategy for the management of neuropathic pain.
Synthetic derivatives of natural cinnamic acids as potential anti‐colorectal cancer agents
Authors: Falbo Federica , Gemma Sandra , Koch Adrian , Mazzotta Sarah , Carullo Gabriele , Ramunno Anna , Butini Stefania , Schneider‐Stock Regine , Campiani Giuseppe , Aiello Francesca 
Published: December 2023

AbstractCinnamic acid and its derivatives represent attractive building blocks for the development of pharmacological tools. A series of piperoniloyl and cinnamoyl‐based amides (6‐9 a‐f) have been synthesized and assayed against a wide panel of colorectal cancer (CRC) cells, with the aim of finding promising anticancer agents. Among all twenty‐four synthesized molecules, 7a, 7e‐f, 9c, and 9f displayed the best antiproliferative activity. The induced G1 cell cycle arrest and the increase in apoptotic cell death was seen in FACS analysis and western Blotting in the colon tumor cell lines HCT116, SW480, LoVo, and HT29, but not in the nontumor cell line HCEC. In particular, 9f overcame the resistance of HT29 cells, which have a mutant p53 and BRAF. Furthermore, 9f, amide of piperonilic acid with the 3,4‐dichlorobenzyl substituent upregulated p21, which is involved in cell cycle arrest as well as in apoptosis induction. Cinnamic acid derivatives might be potential anticancer compounds, useful for the development of promising anti‐CRC agents.
The influence of guide stabilizers and their application sequences on trueness and precision of surgical guides in free end situations: An in vitro analysis
Authors: Liu Runheng , Xia Ruidi , Zhang Linjun , Gan Xuejing , Li Cuijun , Liu Quan , Chen Zhuofan , Chen Zetao 
Published: December 2023

AbstractObjectivesTo evaluate the impact of guide stabilizers and their application sequences on implant placement accuracy of guided implant surgery in multiple teeth loss at free end.Materials and MethodsIn this study, 96 implants were placed in the regions of #34, #36, and #37 of 32 identical mandibular models. The influence of using guide stabilizers or not (group A and group B) and various guide stabilizers application sequences (group B: #34 → #36 → #37; group C: #36 → #34 → #37; group D: #37 → #34 → #36) on implant placement trueness and precision was investigated. Data were analyzed using T‐tests and one‐way ANOVA.ResultsGroup B showed significant benefits in enhancing implant placement precision. Compared to group A, it resulted in reducing 3D‐deviation at crest and 2D deviation in vestibular‐oral direction at both crest and apex. Furthermore, group D demonstrated greater improvement in global implant placement precision by reducing 2D deviation in mesial‐distal direction at both crest and apex. Among the three different stabilizer application sequences, group D exhibited the highest level of implant placement precision.ConclusionsIn cases of missing teeth at distal free end, the use of guide stabilizers and their application sequences does not have a significant impact on implant placement trueness. However, they do improve implant placement precision compared to methods that do not utilize guide stabilizers. Specifically, applying a guide stabilizer first at the furthest implant site to change teeth loss classification from free end to edentulous space with posterior support is the most reliable sequence.
Pharmacokinetics, safety, and efficacy of cedirogant from phase I studies in healthy participants and patients with chronic plaque psoriasis
Authors: Mohamed Mohamed‐Eslam F. , Qian Yuli , D'Cunha Ronilda , Sligh Teresa , Ferris Laura K. , Eldred Ann , Levy Gweneth F. , Hao Shuai , Gannu Shashikanth , Rizzo David G. , Liu Wei , Jazayeri Sasha , Sofen Howard , Carcereri De Prati Roberto 
Published: December 2023

AbstractCedirogant is an inverse agonist of retinoic acid‐related orphan receptor gamma thymus (RORγt) developed for the treatment of moderate to severe chronic plaque psoriasis. Here, we report the results from two phase I studies in which the pharmacokinetics (PK), safety, and efficacy of cedirogant in healthy participants and patients with moderate to severe chronic plaque psoriasis were evaluated. The studies consisted of single (20–750 mg) and multiple (75–375 mg once‐daily [q.d.]) ascending dose designs, with effect of food and itraconazole on cedirogant exposure also evaluated. Safety and PK were evaluated for both healthy participants and psoriasis patients, and efficacy was assessed in psoriasis patients. Following single and multiple doses, cedirogant mean terminal half‐life ranged from 16 to 28 h and median time to reach maximum plasma concentration ranged from 2 to 5 h across both populations. Cedirogant plasma exposures were dose‐proportional after single doses and less than dose‐proportional from 75 to 375 mg q.d. doses. Steady‐state concentrations were achieved within 12 days. Accumulation ratios ranged from approximately 1.2 to 1.8 across tested doses. Food had minimal effect and itraconazole had limited impact on cedirogant exposure. No discontinuations or serious adverse events due to cedirogant were recorded. Psoriasis Area and Severity Index (PASI) and Self‐Assessment of Psoriasis Symptoms (SAPS) assessments demonstrated numerical improvement with treatment of cedirogant 375 mg q.d. compared with placebo. The PK, safety, and efficacy profiles of cedirogant supported advancing it to phase II clinical trial in psoriasis patients.
Future diabetes risk can be predicted by the number of abnormal oral glucose tolerance test values during pregnancy
Authors: Tsur Noa , Pollack Rena , Frankel Meir , Tsur Anat 
Published: December 2023

AbstractAimTo quantify the future risk of type 2 diabetes (T2D) in women with gestational diabetes (GD) based on baseline metabolic characteristics and the number of abnormal values during a 3‐hour 100‐g oral glucose tolerance test (OGTT).Materials and MethodsWe conducted a population‐based retrospective cohort study of 10 023 pregnant women who underwent testing for GD in a large health maintenance organization in Israel using a 100‐g OGTT. Glucose values were obtained at four time points, 0, 60, 120 and 180 minutes.ResultsWe identified 9939 women who met the study criteria. Median follow‐up was 3.25 (interquartile range 1.5‐5.1; maximum 10.1) years. Using women without GD as reference, women with GD were at an increased risk of future T2D (hazard ratio [HR] 5.33 [95% confidence interval {CI} 3.86‐7.34]). This risk increased with a greater number of abnormal OGTT values, with the highest risk seen in women with four abnormal values (HR 16.67 [95% CI 7.94‐35.01]). In a multivariate model, a higher number of abnormal values, Arab ethnicity, higher body mass index, triglycerides and prepregnancy glucose were significantly associated with increased risk. Future T2D risk was also affected by the type of OGTT abnormality; an abnormal fasting value had the greatest risk, whereas an abnormal 3‐hour value had the lowest risk (HR 3.61 [95% CI 2.42‐5.38] vs. 1.50 [95% CI 0.93‐2.43], respectively).ConclusionsGD is a heterogenous disease, with varying degrees of glucose intolerance and subsequent T2D risk. Targeting interventions to women at the highest risk may help to improve postpartum adherence and effective long‐term follow‐up strategies.
Confusion from prenatal diagnosis: Type C persistent fifth aortic arch or right‐side ductus arteriosus
Authors: Li Tian‐gang , Zheng Jiao , Ma Bin 
Published: December 2023

AbstractWe described a case of a double aortic arch (DAA) with a subaortic left brachiocephalic vein (LBCV) and right‐side ductus arteriosus using high‐definition (HD) flow render mode and spatiotemporal image correlation (STIC). We experienced uncertainty regarding this interesting case despite the diagnosis of right‐sided ductus arteriosus. The ductus arteriosus originates from the right pulmonary artery (PA) and converges into the descending aorta (DAO), whereas the vessel originated from the PA and converged into the ascending aorta (AAO). Therefore, we assumed that the vessel connecting the PA to AAO may be a type‐C persistent fifth aortic arch (PFAA).
Weight function analyses and stress intensity factors for corner/surface crack in straight and tapered lugs
Authors: Zhang Bo , Xu Wu , Wu Xue‐Ren 
Published: December 2023

AbstractLug is one of the most important lap joints in many engineering structures, especially airframes. Through‐thickness and part‐through cracks emanating from pin‐loaded lug hole are frequently encountered due to stress concentration. Stress intensity factors for various crack geometries are the prerequisite for damage tolerance design of attachment lug. In this paper, analytical 2D weight functions for through‐thickness crack in lug are derived considering the contact condition between the pin and lug. With the derived 2D weight function, a highly efficient 3D slice synthesis weight function method (SSWFM) is then developed to determine 3D SIFs of hole‐edge corner/surface crack in straight and tapered lugs under various pin loadings. The resulting 3D SIFs are verified by comparisons with the numerical FEM/Franc3D solutions and literature data. The SSWFM is about 1800 times faster than the numerical FEM/Franc3D and therefore will significantly enhance damage tolerance analysis capability for attachment lugs.
Effect of confining pressure strength on the characteristics of energy evolution and fatigue fracture of the coal‐rock structural body
Authors: Li Tan , Yue Zihan , Li Jingkai , Chen Guangbo , Li Qinghai , Lu Yue 
Published: December 2023

AbstractThe stability of coal seam‐overlying strata is significant to the safety of coal mines. The coal‐rock height ratio and confining pressure strength affect the stability of coal seam‐overlying strata. The research purpose of this paper is to obtain the effects of confining pressure and coal‐rock height ratio on the mechanical properties, energy evolution characteristics, and damage variables of structural body through the uniaxial loading, uniaxial cyclic loading, and triaxial cyclic loading experiment. Based on the evolution characteristics of the energy, the concept of energy dissipation ratio is put forward, and the effect of height ratio and confining strength on the energy dissipation ratio are compared and analyzed. The research results of this paper can provide theoretical reference for exploring the stress and energy evolution of coal seam‐overlying strata during chamber excavation and working face mining.
‘VISIONEN VOM IDEALEN GESCHICHTE‐SCHREIBEN UND GESCHICHTE‐MACHENʼ: EPISTEMIC (IN)JUSTICE AND INSURRECTION IN SHARON DODUA OTOO'S HISTORICAL AND MEMORY ACTIVISM
Authors: Windsor Tara Talwar 
Published: December 2023

ABSTRACTThis article explores Sharon Dodua Otoo's historical and memory activism and demonstrates how she challenges epistemic injustices inflicted by dominant models of cultural memory and identity in Germany, particularly in relation to its colonial history. Such epistemic injustice takes two main forms – the ongoing subjugation of subaltern (hi)stories and the under‐acknowledgement of grassroots diasporic activism – resulting in multiple levels of marginalisation and sustaining what the philosopher Charles Mills calls ‘the white epistemology of ignorance’. Building on Sarah Colvin's studies of epistemic resistance in Otoo's literary prose, I argue that Otoo's historical and memory activism is an example of what José Medina refers to as ‘epistemic insurrection’. Otoo's self‐consciously collaborative interventions in historical and memory politics facilitate the kind of ‘beneficial epistemic friction’ expounded by Medina, which is necessary to prevent dominant forces from co‐opting insurgent counter‐histories and counter‐memories. Otoo invokes a community of activist experts and poets, past and present, whose collective knowledge production offers alternative ways of thinking about history and opportunities to subvert the power dynamics of cultural memory. Her activism reaches across diverse genres, media and public domains, and engages multiperspectivity to contribute to more pluralistic modes of doing history and memory.
Gene therapy for haemophilia A and B, from basic principles to clinical implementation: An illustrated review
Authors: Ay Cihan , Frenzel Laurent , Pinachyan Karen , Le Quellec Sandra 
Published: December 2023

AbstractIntroductionWith recent approval of the first two gene therapies for haemophilia A and B, educational materials about AAV‐based gene therapy are needed by the haemophilia community for a better understanding of this novel therapeutic approach and helping healthcare providers and patients making personalized choices amongst an increasing array of therapeutic options.AimTo provide a comprehensive summary of the whole process of AAV‐based gene therapy from basic principles to clinical implementation through an illustrated review.MethodsThe authors, with expertise in and knowledge about gene therapy for haemophilia A and B, reviewed relevant articles from PubMed database and translated them into illustrations.ResultsThe review is divided into eight illustrated sections providing an overview of gene therapy for haemophilia A and B from haemophilia basics and current treatment landscape, principles of the AAV‐based liver‐directed gene therapy, through exploring the efficacy and safety results of published phase III clinical trials, current and future challenges, to implementation in clinical practice, including the hub and spoke models and the patient journey.ConclusionThis illustrated review educates healthcare professionals on AAV‐based gene therapy for haemophilia A and B enabling them to further educate their peers and their patients.
Electrochemical performance and degradation mechanism of rechargeable aqueous Al2O3@Zn//MnO2 battery
Authors: Lee Sihyun , So Younghee , Mhin Sungwook 
Published: December 2023

AbstractRechargeable aqueous Zn ion batteries (AZIBs) have attracted significant attention as a promising alternative to Li‐ion batteries due to the use of water‐based electrolytes, high energy density per volume, and cost‐effectiveness. However, various parasitic reactions relating to hydrogen evolution reaction, corrosion, and dendrite growth in the Zn anode can result in the degradation of the electrochemical performance of AZIBs. Therefore, understanding the mechanisms underlying these various phenomena and their role in the electrochemical performance of AZIBs provides valuable insights for the development of anode and cathode materials. In this study, we investigate the effect of the MnO2 cathode and Al2O3‐coated Zn anode on the electrochemical performance of the AZIBs. The experimental results show that Al2O3‐coated Zn anodes efficiently suppress the dendrite growth on the Zn. However, significant cycling fade of the full cell comprising of an Al2O3‐coated Zn anode and MnO2 cathode was observed during continuous charge/discharge cycles. The poor cycle performance can be mainly attributed to the phase transformation of MnO2–Mn2O3 and the formation of various byproducts, which highlights the importance of the electrochemical stability of cathode materials in AZIBs to improve the cycle performance.