bluuebunny/crossref_metadata_2025_split huggingface dataset:
Replacement of a High-fat Diet with a Standard Chow Diet Reduces Daytime Food Intake in Obese Mice and Normalizes Fat Accumulation and Metabolic Parameters
Authors: Melo Vanessa Cristina de Souza , Vettorazzi Jean Franciesco , Couto Julia Nicoly Bohn , Cabreira Julia Martins , Balbo Sandra Lucinei 
Published: February 2025

Introduction: The consumption of ultra-processed foods rich in fat has contributed to the global rise in obesity and other metabolic disorders, including excess adipose tissue accumulation and Non-Alcoholic Fatty Liver Disease (NAFLD). Although physical exercise and dietary education are first-line treatments for weight loss, restrictive diets are often used to accelerate weight reduction. However, these diets are generally unsustainable in the long term and frequently lead to weight regain.
Aims: To evaluate the effects of replacing a high-fat diet with a standard chow diet (ad libitum) on food intake, fat accumulation, glycemic homeostasis, and non-alcoholic fatty liver disease.
Methodology: Animals were divided into two groups: one fed a high-fat diet and the other a standard diet for 8 weeks. Then, half of the animals on the high-fat diet had their food replaced with a standard diet. Body weight was measured weekly. After an additional 7 weeks, food intake was assessed, and glucose and insulin tolerance tests were performed. The animals were euthanized 8 weeks after the dietary intervention, and liver tissue was collected for histological analysis.
Results: The high-fat diet induced obesity and metabolic changes, including hyperglycemia, insulin resistance, dyslipidemia, and hepatic steatosis. Replacing it with a standard diet, even without influencing total caloric intake, reduced daytime food intake and successfully restored body weight, normalized blood glucose and lipid profiles, and improved hepatic steatosis.
Conclusion: Switching to a standard chow diet, even without reducing total caloric intake, decreased daytime food intake, restored body weight, normalized blood glucose and lipid profiles, and improved hepatic steatosis in mice.
Health Care Spending Increases and Value in South Korea
Authors: Park Sungchul , Dieleman Joseph L. , Weaver Marcia R. , Bae Giryeon , Eggleston Karen 
Published: January 2025

ImportanceHealth care spending in South Korea (hereafter Korea) nearly doubled from 2010 to 2019. However, little is known about the drivers and effectiveness of these spending increases in terms of changes in disability-adjusted life-years (DALYs).ObjectivesTo evaluate the factors contributing to changes in health care spending and DALYs and estimate the value of health care spending from 2010 to 2019 in Korea.Design, Setting, and ParticipantsThis cross-sectional study of the population of Korea used 2010 and 2019 data from the National Health Insurance Service for health care spending, and from the Global Burden of Disease 2019 for DALYs. Changes from 2010 to 2019 were decomposed into changes in several factors, including population size, aging, and per-person measures of spending or DALYs. Data analyses were performed from April 2023 to June 2024.Main Outcomes and MeasuresHealth care spending was calculated as the total expenditure on medical and long-term care, and health gains were measured as DALYs averted. The value of health care spending was estimated as the ratio of changes in spending per person to changes in DALYs per person.ResultsTotal health care spending in Korea increased from $55.0 billion in 2010 to $92.0 billion in 2019. Increases in spending per person accounted for 52.9% of the increase, followed by population aging and population size (35.6% and 11.4%). Total DALYs increased from 11.4 million to 12.2 million. Population aging accounted for 269.4% of the increase, followed by population growth (64.0%). However, DALYs per person decreased (−233.4%), reflecting a lower per capita health burden given the country’s age structure. Assuming 50% and 80% of these health improvements could be attributed to health care spending, the estimated spending per DALY averted was $20 678 and $12 924, respectively. The estimate was slightly larger when excluding DALYs not directly impacted by medical care ($23 687). Korea’s spending per DALY averted is at the lower range of estimates and comparable to that of other high-income countries.Conclusions and RelevanceThis cross-sectional study indicates that increased spending per person, which accounted for half of the total health care spending increase, was associated with improved overall health, evidenced by substantially fewer DALYs. These findings contribute to understanding and evaluating the value of health care spending in Korea.
Duration in Immigration Detention and Health Harms
Authors: Saadi Altaf , Patler Caitlin , Langer Paola 
Published: January 2025

ImportanceLength of custody is a mechanism by which carceral systems can worsen health. However, there are fewer studies examining US immigration detention, in large part because US immigration detention is largely privately operated and opaque by design.ObjectivesTo examine the association between duration spent in US immigration detention with subsequent health outcomes.Design, Setting, and ParticipantsThis cross-sectional study used a referral sample of recently detained immigrants who were released from Immigrations and Customs Enforcement (ICE) under a series of court orders in 2020 and 2021. Data were analyzed from June 2023 to October 2024.ExposureDetention duration less than 6 months vs 6 months or longer.Main Outcomes and MeasuresWe used multivariable regression analysis to assess the association of detention duration and several variables: (1) self-rated health, (2) mental illness (Kessler 6-item psychological distress scale), and (3) posttraumatic stress disorder (PTSD) (Primary Care-PTSD-5 Screen). We then calculated the likelihood of experiencing each outcome, controlling for covariates. As a robustness check, we conducted sensitivity analyses with detention duration as a continuous measure.ResultsThe study included 200 respondents (mean [SD] age, 40.3 [10.1] years; 175 male [87.5%]; 149 Hispanic or Latino ethnicity [74.5%]). Results revealed a high prevalence of poor self-rated health, mental illness, and PTSD for all respondents, but especially among those who had been detained for 6 months or longer, who had significantly higher likelihood of poor or fair self-rated health (49.1% [95% CI, 40.5%-57.6%] vs 30.4% [95% CI, 21.8%-39.1%]; P &amp;lt; .001), mental illness (37.0% [95% CI, 28.2%-45.8%] vs 20.7% [95% CI, 12.6%-28.7%]; P &amp;lt; .001), and PTSD (59.3% [95% CI, 50.3%-68.3%] vs 34.8% [95% CI, 25.3%-44.3%]; P &amp;lt; .001). Sensitivity analysis confirmed the general robustness of these findings, with longer detention duration significantly associated with mental illness (OR, 1.11 [95% CI, 1.02-1.20]; P = .01) and PTSD (OR, 1.11 [95% CI, 1.03-1.20]; P = .005) in our adjusted models.Conclusions and RelevanceIn this cross-sectional study, detained immigrants experienced a high prevalence of poor health, mental illness, and PTSD, with detention periods of 6 months or more associated with higher rates compared with those detained less than 6 months. Duration of custody is one mechanism by which immigration detention might be a catalyst for worsening health.
City-Level Sugar-Sweetened Beverage Taxes and Changes in Adult Body Mass Index
Authors: Liu Emily F. , Young Deborah R. , Sidell Margo A. , Lee Catherine , Cohen Deborah A. , Barton Lee J. , Falbe Jennifer , Inzhakova Galina , Sridhar Sneha , Voorhees Allison C. , Han Bing , Hedderson Monique M. 
Published: January 2025

ImportanceSugar-sweetened beverage (SSB) excise taxes are popular policy interventions aimed at decreasing SSB purchasing and consumption to improve cardiometabolic health and generate revenue for public health initiatives. There is limited evidence that these taxes in the US are associated with weight-related outcomes in adults, a primary contributor to cardiometabolic health.ObjectiveTo determine the association between SSB excise taxes and adult body mass index (BMI) and proportion of adults with overweight or obesity among California cities and assess whether associations vary by demographic characteristics.Design, Setting, and ParticipantsThis cohort study compared California cities with SSB taxes (Albany, Berkeley, Oakland, and San Francisco) and demographically matched cities without SSB excise taxes from 6 years before the tax and 4 to 6 years after the tax from January 2009 through December 2020 using electronic health record data. Participants were Kaiser Permanente (KP) members aged 20 to 65 years at cohort entry with at least 1 pretax and 1 posttax BMI measurement. Data were analyzed from January 2021 to May 2023.ExposureImplementation of city-level SSB excise taxes.Main outcomes and measuresMean BMI and proportion of adults with overweight or obesity. Analysis used the differences-in-differences (DID) method.ResultsThe cohort had a total of 1 044 272 members (178 931 participants in 4 cities with excise taxes; mean [SD] age, 39.7 [11.2] years; 99 501 [55.6%] female; 865 343 participants in 40 control cities without excise taxes; mean [SD] age, 39.9 [11.6] years; 480 155 [55.5%] female). DID estimates for mean BMI showed a modest decrease among adults aged 20 to 39 years (20-25 years: −0.30; 95% CI, −0.51 to −0.08; 26-39 years: −0.19; 95% CI, −0.37 to −0.20), female participants (−0.19; 95% CI, −0.26 to −0.11), and White participants (−0.19; 95% CI, −0.35 to −0.04) living in cities with SSB excise taxes. There was a statistically significant reduction in mean BMI in Berkeley (−0.16; 95% CI, −0.27 to −0.04). There were no overall differences in BMI or proportion with overweight or obesity.Conclusions and relevanceIn this cohort study, SSB excise taxes were associated with reduced mean BMI among adults in demographic subgroups, including in young adults who consumed the most SSBs, and in Berkeley. Future research should examine the mechanisms of these associations to inform how SSB taxes could be more equitable for weight-related outcomes.
Crystalline Hydrogen Enhanced Dual‐Acid Quasi‐Solid‐State Proton Battery
Authors: Meng Fanhao , Dong Xiaoyu , Wu Haiyang , Wu Zhiyuan , Dou Hui , Zhang Xiaogang 
Published: January 2025

AbstractProton batteries are considered promising due to their high‐power output, cost‐effectiveness, and safety. However, they also face challenges such as low voltage, limited capacity, and poor cycle stability. To address these challenges, a dual‐acid quasi‐solid‐state electrolyte (SSAE) is developed by combining H2SiO3 with H2SO4. This electrolyte has the decomposition voltage of 2.15 V and ultra‐high conductivity of 95 mS cm⁻¹ (1.5 mS cm⁻¹ at −70 °C). Leveraging this high decomposition voltage, the specific capacity of MoO3 is successfully enhanced to 1.74 times than its original value at a current density of 5 A g−1 by harnessing the hydrogen evolution/oxidation reaction (HER/HOR) of lattice hydrogen (H·ad,s) in MoO3 at low potentials, which is typically regarded as a significant factor to suppress the gas evolution. Notably, the voltage achieved a record‐breaking 1.8 V in the Prussian Blue Analog //MoO3 system at room temperature. The full cell consisting of HVFe‐PBA (pre‐protonated vanadium hexacyanoferrate)//SSAE//MoO3 exhibited outstanding electrochemical performance at both room temperature and low temperatures. As a proof‐of‐concept, a pouch cell is assembled with an energy density of 72.3 Wh kg−1, and even it maintained an energy density of 40.7 Wh kg−1at −60 °C.
Ischemic Myocardium Targeting Peptide‐Guided Nanobubbles for Multimodal Imaging and Treatment of Coronary Microvascular Dysfunction
Authors: Yu Bo , Pang Ziwei , Zhao Jing , Xue Jingyi , Lo Hsuan , Gu Tiancheng , Zhang Ping , Tian Jiawei , Du Guo‐Qing 
Published: January 2025

AbstractCoronary microvascular dysfunction (CMD) refers to clinical symptoms caused by structural and functional damage to coronary microcirculation. The timely and precise diagnosis of CMD‐related myocardial ischemia is essential for improving patient prognosis. This study describes a method for the multimodal (fluorescence, ultrasonic, and photoacoustic) noninvasive imaging and treatment of CMD based on ischemic myocardium‐targeting peptide (IMTP)‐guided nanobubbles functionalized with indocyanine green (IMTP/ICG NBs) and characterizes their basic characteristics and in vitro imaging and targeting abilities. The IMTP/ICG NBs enable the accurate location of myocardial ischemia via photoacoustic imaging, and when loaded with tannic acid (TA), can be used to effectively treat myocardial ischemia and fibrosis in CMD mice, achieving an effect superior to that of free TA. The origin of this high therapeutic efficiency is revealed by transcriptomic and proteomic analyses. This investigation lays the groundwork for visual monitoring and the drug‐targeted treatment of CMD.
TPMS‐Gyroid Scaffold‐Mediated Up‐Regulation of ITGB1 for Enhanced Cell Adhesion and Immune‐Modulatory Osteogenesis
Authors: Wang Jing , Huang Zenan , Han Zhenzhong , Luan Jing , Li Zihan , Guo Xutong , Yang Dongxu , Cui Yazhou , Han Jinxiang , Xu Duo 
Published: January 2025

AbstractThe porous structure is crucial in bone tissue engineering for promoting osseointegration. Among various structures, triply periodic minimal surfaces (TPMS) ‐Gyroid has been extensively studied due to its superior mechanical and biological properties. However, previous studies have given limited attention to the impact of unit cell size on the biological performance of scaffolds. In this research, four TPMS‐Gyroid titanium scaffolds with different unit cell sizes (TG15, TG20, TG25, and TG30) are fabricated using Selective Laser Melting (SLM) to explore their effects on osseointegration. Mechanical tests revealed that TG15 and TG20 exhibited superior compressive strength. In vitro experiments demonstrated that TG20 facilitated better cell adhesion through robust integrin protein expression initially, which subsequently enhanced cell proliferation and osteogenic differentiation. Furthermore, macrophages on TG20 showed higher Integrin β1 (ITGB1) expression, promoting their polarization to the M2 phenotype, which suppressed inflammation, fostered bone integration, and angiogenesis. In vivo studies confirmed TG20's effectiveness in promoting bone ingrowth by reducing inflammation. This study highlights TG20's structural advantages, making it a promising bone scaffold with exceptional osteogenic and angiogenic properties through osteoimmune microenvironment modulation. Therefore, TG20 holds significant potential for applications in bone tissue engineering.
UV‐Solar Photocatalysis for the Simultaneous Removal of Arsenic and Mercury in Washing Solutions from Polluted Marine Sediments
Authors: Muscetta Marica , Race Marco , D'Agostino Fabio , Sprovieri Mario , Clarizia Laura 
Published: January 2025

AbstractAn environmentally sustainable strategy has been developed for simultaneously removing arsenic and mercury from wastewater, potentially coming from washing of polluted marine sediments. Citric acid (CA), a biodegradable chelating agent, forms stable complexes with both metals, which can be extracted from contaminated sediments through ex situ sediment washing. A solar photocatalytic method has been developed to separate toxic metals from wastewater and degrade CA. Increasing the TiO2 photocatalyst load enhances arsenic adsorption under dark conditions. Total arsenic removal is achieved during photocatalytic decontamination using 1000 ppm of TiO2. Fe(III)–hydroxides formed in the presence of Fe(III) further adsorb arsenic. Nearly total arsenic removal is achieved even under seawater conditions and visible light irradiation only. The removal of arsenic in different oxidation states has been successfully demonstrated. The UV–vis/TiO2/CA photocatalytic system has also proven highly effective for mercury removal from wastewater. Although seawater conditions slightly slow the removal process, complete mercury removal is achieved even under visible light irradiation. Finally, a combined photocatalytic approach has been developed for the removal of both arsenic and mercury, achieving 100% removal within few minutes of light irradiation. The reaction mechanism has been depicted based on intermediates and reaction products detected during the photocatalytic process.
Turning Waste into Treasure: Functionalized Biomass‐Derived Carbon Dots for Superselective Visualization and Eradication of Gram‐Positive Bacteria
Authors: Xu Ke‐Fei , Wang Zihao , Cui Macheng , Jiang Yuhan , Li Chengcheng , Wang Zi‐Xi , Li Ling‐Yi , Jia Chenyang , Zhang Lijie , Wu Fu‐Gen 
Published: January 2025

AbstractGram‐positive bacteria pose significant threats to human health, necessitating the development of targeted bacterial detection and eradication strategies. Nevertheless, current approaches often suffer from poor targeting specificity. Herein, the study utilizes purple rice lixivium to synthesize biomass carbon dots (termed BCDs) with wheat germ agglutinin‐like residues for precisely targeting Gram‐positive bacteria. Subsequently, fluorescein isothiocyanate (FITC) molecules are grafted onto BCDs to yield FITC‐labeled BCDs (termed CDFs), which can selectively and rapidly (≤5 min) stain bacterial cell wall and particularly target the peptidoglycan component. Strikingly, CDFs achieve superselective visualization of Gram‐positive bacteria even in the presence of mammalian cells and Gram‐negative bacteria. Furthermore, protoporphyrin (PpIX) molecules are conjugated onto BCDs to yield PpIX‐modified BCDs (termed CDPs), which can induce bacterial aggregation and in situ generate singlet oxygen for realizing enhanced antibacterial photodynamic therapy (PDT). At the minimum bactericidal concentration of CDPs (PpIX: 5 µg mL−1), CDP‐mediated PDT disrupts bacterial structure and metabolism pathways, thereby affecting bacterial interactions to eradicate biofilms. Importantly, CDP‐mediated PDT efficiently modulates antiinflammatory responses to promote wound healing in the bacteria‐infected mice. This study underscores the significance of harnessing renewable and cost‐effective biomass resources for preparing Gram‐positive bacteria‐targeting theranostic agents, which may find potential clinical applications in the future.
3‐HKA Promotes Vascular Remodeling After Stroke by Modulating the Activation of A1/A2 Reactive Astrocytes
Authors: Chen Jun‐Min , Shi Guang , Yu Lu‐Lu , Shan Wei , Sun Jing‐Yu , Guo An‐Chen , Wu Jian‐Ping , Tang Tie‐Shan , Zhang Xiang‐Jian , Wang Qun 
Published: January 2025

AbstractIschemic stroke is the most common cerebrovascular disease and the leading cause of permanent disability worldwide. Recent studies have shown that stroke development and prognosis are closely related to abnormal tryptophan metabolism. Here, significant downregulation of 3‐hydroxy‐kynurenamine (3‐HKA) in stroke patients and animal models is identified. Supplementation with 3‐HKA improved long‐term neurological recovery, reduced infarct volume, and increased ipsilateral cerebral blood flow after distal middle cerebral artery occlusion (MCAO). 3‐HKA promoted angiogenesis, functional blood vessel formation, and blood‐brain barrier (BBB) repair. Moreover, 3‐HKA inhibited A1‐like (neurotoxic) astrocyte activation but promoted A2‐like (neuroprotective) astrocyte polarization. Proteomic analysis revealed that 3‐HKA inhibited AIM2 inflammasome activation after stroke, and co‐labeling studies indicated that AIM2 expression typically increased in astrocytes at 7 and 14 days after stroke. Consistently, in co‐cultures of primary mouse brain microvascular endothelial cells and astrocytes, 3‐HKA promoted angiogenesis after oxygen‐glucose deprivation (OGD). AIM2 overexpression in astrocytes abrogated 3‐HKA‐driven vascular remodeling in vitro and in vivo, suggesting that 3‐HKA may regulate astrocyte‐mediated vascular remodeling by impeding AIM2 inflammasome activation. In conclusion, 3‐HKA may promote post‐stroke vascular remodeling by regulating A1/A2 astrocyte activation, thereby improving long‐term neurological recovery, suggesting that supplementation with 3‐HKA may be an efficient therapy for stroke.
Boosting the Activity and Stability of 3‐Hydroxyphenothiazine Derivatives for Aqueous Organic Flow Batteries
Authors: Zhang Mengqi , Mu Chenkai , Li Tianyu , Zhang Changkun , Li Xianfeng 
Published: January 2025

AbstractAqueous organic flow batteries (AOFBs) represent one of the most promising technologies for stationary energy storage due to their features of abundant resources and high tunability. Phenothiazines have stable conjugated structures and are considered one of the most potential catholytes for AOFBs. However, the highly conjugated structure of phenothiazines is always hydrophobic and reduces the molecular polarity, which makes it challenging to achieve high capacity and energy efficiency. Herein, a new class of 3‐hydroxyphenothiazine derivatives with a high solubility of 1.8 m and fast redox kinetics by introducing the hydrophilic tertiary ammonium groups. The designed 7‐bromo‐2,4‐dimethylaminemethylene‐3‐hydroxyphenothiazine (BDAHP) based cell not only exhibited an ultra‐stable cycling capacity (over 10 000 cycles with a capacity fade rate of 0.00048% per cycle for the symmetric cell) but also achieved a high energy efficiency of 82.3% (80 mA cm−2 at 0.5 m). Furthermore, the cell also displayed a highly reversible catholyte capacity of 82 Ah L−1 at a high concentration of 1.7 m and wide temperature adaptability (−15–60 °C). Combining the high volumetric capacity, fast redox reaction, and stability, the hydroxyl‐substituted PTZ demonstrates great potential for large‐scale energy storage.
Advancing Humidity‐Resistant Triboelectric Nanogenerators Through MoS₂‐Encapsulated SiO₂ Nanoparticles for Self‐Powered Gas Sensing Applications
Authors: Kim Do‐Heon , Park Ji Young , Choi Han Sol , Cho Jeonghoon , Kim Hyun Soo , Mo Jeong Eun , Kim Jin‐Kyeom , Yoon Tae Kyoung , Hur Sung Hun , Kim Jae Joon , Park Hye Sung , Song Hyun Cheol , Baik Jeong Min 
Published: January 2025

AbstractIn this study, the humidity‐resistant triboelectric nanogenerators (TENGs) utilizing MoS₂‐encapsulated SiO₂ nanoparticles (NPs), aimed at enhancing self‐powered gas sensing applications, are reported. The core‐shell structure, featuring a thin MoS₂ layer uniformly grown on SiO₂, addresses common humidity‐induced performance degradation. The growth mechanism involves the decomposition and sulfidation of molybdenum species, with MoS₂ selectively nucleating on SiO₂ to form a stable, hydrophobic shell. This MoS₂ layer effectively shields the SiO₂ interface from water molecule penetration, thus stabilizing charge density and significantly reducing charge decay, even under high humidity conditions. TENGs constructed with these core‐shell NPs exhibit high triboelectric charge density and exceptional durability, retaining more than 70% output over 25 h at 99% relative humidity (RH). Furthermore, the fabricated TENG reliably powers a gas sensor array, enabling accurate gas detection in extreme humidity. This work demonstrates the potential of MoS₂‐encapsulated SiO₂ TENGs as robust, self‐powered energy solutions for environmental monitoring and wearable devices in challenging humidity conditions.