bluuebunny/crossref_metadata_2025_split huggingface dataset:
Best proximity points for alternative p-contractions
Authors: Zhou Mi , Secelean Nicolae Adrian , Saleem Naeem , Abbas Mujahid 
Published: January 2024

AbstractCyclic mappings describe fixed paths for which each point is sequentially transmitted from one set to another. Cyclic mappings satisfying certain cyclic contraction conditions have been used to obtain the best proximity points, which constitute a suitable framework for the mirror reflection model. Alternative contraction mappings introduced by Chen (Symmetry 11:750, 2019) built a new model containing several mirrors in which the light reflected from a mirror does not go to the next mirror sequentially, and its path may diverge to any other mirror. The aim of this paper is to present a new variant of alternative contraction called alternative p-contraction and study its properties. The best proximity point result for such contractions under the alternative UC property is proved. An example to support the result proved herein is provided.
Homocysteine and mitochondrial quality control in diabetic retinopathy
Authors: Malaviya Pooja , Kowluru Renu A. 
Published: January 2024

Abstract
Background
Diabetic retinopathy is a progressive disease, and one of the key metabolic abnormalities in the pathogenesis of diabetic retinopathy, mitochondrial damage, is also influenced by the duration of hyperglycemia. Mitochondrial quality control involves a coordination of mitochondrial dynamics, biogenesis and removal of the damaged mitochondria. In diabetes, these processes are impaired, and the damaged mitochondria continue to produce free radicals. Diabetic patients also have high homocysteine and reduced levels of hydrogen sulfide, and hyperhomocysteinemia is shown to exacerbate diabetes-induced mitochondrial damage and worsen their dynamics. This study aims to investigate the temporal relationship between hyperhomocysteinemia and retinal mitochondrial quality control in diabetic retinopathy.

Methods
Human retinal endothelial cells incubated in 20 mM d-glucose for 24 to 96 h, in the absence or presence of 100 µM homocysteine, with/without a hydrogen sulfide donor GYY4137, were analyzed for mitochondrial ROS (MitoSox fluorescence), DNA damage (transcripts of mtDNA-encoded ND6 and CytB), copy numbers, oxygen consumption rate (Seahorse XF analyzer) and mitophagy (mitophagosomes immunofluorescence labeling and flow cytometry). Results were confirmed in the retina from mice genetically manipulated for hyperhomocysteinemia (cystathionine β-synthase deficient mice, Cbs+/−), streptozotocin-induced diabetic for 8 to 24 weeks. At 24 weeks of diabetes, vascular health was evaluated by counting acellular capillaries in the trypsin digested retinal vasculature and by fluorescein angiography.

Results
Homocysteine, in high glucose medium, exacerbated mitochondrial ROS production, mtDNA damage and impaired mitochondrial respiration within 24 h, and slowed down/worsened mitochondrial biogenesis and mitophagy, as compared to 48 to 96 h in high glucose alone. GYY4137 supplementation ameliorated homocysteine + high glucose-induced mitochondrial damage and impairment in biogenesis and mitophagy. Similar results were obtained from Cbs+/− mice-mitochondrial ROS, mtDNA damage and decline in biogenesis and mitophagy were observed within eight weeks of diabetes vs. 16 to 24 weeks of diabetes in Cbs+/+ mice, and at 24 weeks of diabetes, Cbs+/− mice had significantly higher acellular capillaries and vascular leakage.

Conclusions
Hyperhomocysteinemia, in a hyperglycemic environment, overwhelms the mitochondria, accelerating and exacerbating their dysfunction, and also delays/worsens their removal, augmenting the development of diabetic retinopathy. Thus, our results strengthen the importance of maintaining homocysteine-hydrogen sulfide balance during the early stages of diabetes for a patient to prevent/retard vision loss.
Fintech research: systematic mapping, classification, and future directions
Authors: Liu Qianhua , Chan Ka-Ching , Chimhundu Ranga 
Published: January 2024

AbstractThis systematic mapping study provides a comprehensive review of current Fintech publications, analyzing the current state, maturity level, and future directions of Fintech research. Reviewing 518 Fintech articles across four academic databases from 2008 to 2021, we find a significant increase in Fintech studies, especially in Quartile 1 and Quartile 2 journals. Fintech and banking, Fintech development, and Fintech adoption are the most popular research areas, and articles in these areas are increasing. We propose a classification scheme for Fintech studies across five dimensions. Our study provides a unique perspective on the subject, enabling researchers and practitioners to re-evaluate the direction and scope of future Fintech research.
Administration of ivermectin to cattle induced mortality, reduced fecundity and survivorship of Anopheles arabiensis in Ethiopia: an implication for expansion of vector control toolbox
Authors: Damene Ephrem , Massebo Fekadu 
Published: January 2024

Abstract
Background
Although many countries have shown interest in eliminating malaria, approaches that complement existing vector control interventions are needed because existing methods have been scaled up but malaria still persists. Therefore, the effect of ivermectin administration to cattle was evaluated for its effect on mortality, survivorship and mortality of laboratory reared Anopheles arabiensis.

Methods
Three calves were randomly selected and injected with ivermectin at a therapeutic dose of 0.2 mg/kg, while the other two calves received no treatment and served as controls. Five tents were constructed for the trial. Calves were housed in tents (one per tent) and then 30 starved female An. arabiensis were introduced into each tent. Only fully engorged females were collected from each tent and placed in different mosquito cages to monitor their mortality, survival and fecundity. Data analysis was done using SPSS version 16.

Results
During the follow-up period (until day 21), ivermectin induced significantly higher mortality when compared to controls. It resulted in an average 24-h mortality rate of 81.6% against An. arabiensis on the first day following treatment. 100% An. arabiensis that fed on ivermectin-treated calves on the first day after treatment died within four days. Egg production rate of An. arabiensis that fed on ivermectin-treated calves was significantly lower compared to controls (F = 768.7, P < 0.001).

Conclusion
In conclusion, ivermectin induced mortality, reduced fecundity and survivorship of laboratory maintained An. arabiensis. Further study is recommended using a wild mosquito population. Moreover, mass ivermectin administration to domestic animals could be recommended to supplement the existing indoor based interventions.
Inhibition of CSF1R and KIT With Pexidartinib Reduces Inflammatory Signaling and Cell Viability in Endometriosis
Authors: Dunn Timothy N , Cope Dominique I , Tang Suni , Sirupangi Tirupataiah , Parks Sydney E , Liao Zian , Yuan Fei , Creighton Chad J , Masand Ramya P , Alpuing Radilla Linda , Guan Xiaoming , Detti Laura , Monsivais Diana , Matzuk Martin M 
Published: January 2024

Abstract
Endometriosis is a common and debilitating disease, affecting ∼170 million women worldwide. Affected patients have limited therapeutic options such as hormonal suppression or surgical excision of the lesions, though therapies are often not completely curative. Targeting receptor tyrosine kinases (RTKs) could provide a nonhormonal treatment option for endometriosis. We determined that 2 RTKs, macrophage-colony stimulating factor 1 receptor (CSF1R) and mast/stem cell growth factor receptor KIT (KIT), are overexpressed in endometriotic lesions and could be novel nonhormonal therapeutic targets for endometriosis. The kinase activity of CSF1R and KIT is suppressed by pexidartinib, a small molecule inhibitor that was recently approved by the US Food and Drug Administration. Using immunohistochemistry, we detected CSF1R and KIT in endometriotic tissues obtained from peritoneal lesions, colorectal lesions, and endometriomas. Specifically, we show that KIT is localized to the epithelium of the lesions, while CSF1R is expressed in the stroma and macrophages of the endometriotic lesions. Given the high epithelial expression of CSF1R and KIT, 12Z endometriotic epithelial cells were used to evaluate the efficacy of dual CSF1R and KIT inhibition with pexidartinib. We found that pexidartinib suppressed activation in 12Z cells of JNK, STAT3, and AKT signaling pathways, which control key proinflammatory and survival networks within the cell. Using quantitative real-time polymerase chain reaction, we determined that pexidartinib suppressed interleukin 8 (IL8) and cyclin D1 (CCND1) expression. Lastly, we demonstrated that pexidartinib decreased cell growth and viability. Overall, these results indicate that pexidartinib-mediated CSF1R and KIT inhibition reduces proinflammatory signaling and cell viability in endometriosis.
(In)visible Subjects: Pranlal Patel's Women at Work in Ahmedabad, India, 1937
Authors: Trivedi Lisa 
Published: January 2024

Abstract
Approximately one hundred photographs of women at work in the city of Ahmedabad, India, were taken in 1937 by Pranlal K. Patel, at the request of the premier women's social reform organization, the Jyoti Sangh. Rather than depicting women's contributions as peripheral to the productivity of Ahmedabad's economic life and isolated from the public, Patel pictured women as subjects working in the city's major marketplaces and as integral to the city's industrial productivity. This article argues that historical photography may provide what Elizabeth Edwards terms a “historiographical think-space” that challenges conventional historical sources and the narratives they produce. By engaging Ariella Azoulay's ethical spectators in the civil contract of photography, historians can use historical photography to confront the historical roots of inequality that shape our world today.
Mending Memory by Hand and Brush: Socialist China's Colored Photographs
Authors: Zhang Shaowen 
Published: January 2024

Abstract
A remarkable quality of Chinese vernacular photographs during the socialist period is their efflorescence of color. From studio colorists well-versed in the art of potassium cyanide to private brushstrokes in thick marker, the prevalence of photo-coloring (zhuose) evidenced a marked degree of dissatisfaction with an unmanipulated print. Bracketed by Chinese photo studios’ national institutionalization in 1956 and the promulgation of commercial color rolls in the 1980s, this discussion builds from extant scholarship on Chinese vernacular photographs of the 1960s and 1970s. By analyzing colored Tiananmen photographs of the Cultural Revolution, a posthumous biography of photo-colorist Zhou Qi, and various examples from the volume Anonymous Photos (Yiming zhao), this article demonstrates that photo-coloring was a crucial aesthetic agent in negotiations between officially mandated postures and bold ways of inscribing individual experiences as chromatic repositories of memory and meaning, marking a site where mass visuality and more specific imaginations of the self collided into color.
Framing China's Uneven Urban Landscape: An Interview with Chen Ronghui
Authors: Hou Dorothee Xiaolong 
Published: January 2024

Abstract
Chen Ronghui (b.1989) is a Chinese photographer based in Shanghai. His work focuses on China's urbanization and de/industrialization, particularly the issues arising from the position of the individual within their shifting urban environment. While China's drastic urbanization since its 1980s’ economic reform has been examined by various photographers, Chen's “urban landscape” trilogy, completed over the past decade, offers neither a panoramic view of China's urbanization nor close-ups of specific social and environmental issues; rather, it captures China's uneven development in three distinct locations and moments in time: chemical plants outside Hangzhou after an acid spill, Shanghai after the opening of the first Disneyland in mainland China, and the shrinking cities in the northeastern Rust Belt. In this interview, Chen speaks on his transition from photojournalism to art photography, specifically his experiment with large-format photography, as well as the conundrum of depicting social issues while exploring photography as a universal language.
Systematic review of machine-learning models in orthopaedic trauma
Authors: Dijkstra Hidde , van de Kuit Anouk , de Groot Tom , Canta Olga , Groot Olivier Q. , Oosterhoff Jacobien H. , Doornberg Job N. 
Published: January 2024

AimsMachine-learning (ML) prediction models in orthopaedic trauma hold great promise in assisting clinicians in various tasks, such as personalized risk stratification. However, an overview of current applications and critical appraisal to peer-reviewed guidelines is lacking. The objectives of this study are to 1) provide an overview of current ML prediction models in orthopaedic trauma; 2) evaluate the completeness of reporting following the Transparent Reporting of a multivariable prediction model for Individual Prognosis Or Diagnosis (TRIPOD) statement; and 3) assess the risk of bias following the Prediction model Risk Of Bias Assessment Tool (PROBAST) tool.MethodsA systematic search screening 3,252 studies identified 45 ML-based prediction models in orthopaedic trauma up to January 2023. The TRIPOD statement assessed transparent reporting and the PROBAST tool the risk of bias.ResultsA total of 40 studies reported on training and internal validation; four studies performed both development and external validation, and one study performed only external validation. The most commonly reported outcomes were mortality (33%, 15/45) and length of hospital stay (9%, 4/45), and the majority of prediction models were developed in the hip fracture population (60%, 27/45). The overall median completeness for the TRIPOD statement was 62% (interquartile range 30 to 81%). The overall risk of bias in the PROBAST tool was low in 24% (11/45), high in 69% (31/45), and unclear in 7% (3/45) of the studies. High risk of bias was mainly due to analysis domain concerns including small datasets with low number of outcomes, complete-case analysis in case of missing data, and no reporting of performance measures.ConclusionThe results of this study showed that despite a myriad of potential clinically useful applications, a substantial part of ML studies in orthopaedic trauma lack transparent reporting, and are at high risk of bias. These problems must be resolved by following established guidelines to instil confidence in ML models among patients and clinicians. Otherwise, there will remain a sizeable gap between the development of ML prediction models and their clinical application in our day-to-day orthopaedic trauma practice.Cite this article: Bone Jt Open 2024;5(1):9–19.
Enhancement sensing of biomarkers by acoustic graphene plasmonic mode
Authors: Piao Hang , Chen Qing , Li Xiangyu , Wu Jingzhi , Wang Yanhong , Li Mengwei 
Published: January 2024

The sensitivity and accuracy of molecular detection using THz technology are limited due to the weak interaction between THz waves and biomolecules. An acoustic graphene plasmons (AGP) resonator could have ultra-compressed light fields and provide strong light-matter interactions at the microscopic level. In the paper, the AGP construction for bio-molecules sensing with high sensitivity is proposed, which consists of a continuous graphene and nano-gap separated metal strip, and a continuous gold layer separated by silica. By coupling free-space light to the nanogap to form a sonic graphene plasma, the gold reflector further improves the excitation efficiency of the sonic graphene plasma and achieves good free-space incident light absorption (97.2%). Adjusting the width of the metal band to achieve four absorption peaks in the range of molecular vibration frequency, adding the test molecule, the absorption rate at the molecular vibration frequency of 13 µm is increased from the original 5%–40%, which allows precise analysis of molecular structure information. In the mid-infrared and terahertz range, the system can offer promising applications for light-matter interactions and efficient coupled sensing of long spectra compared to conventional graphene plasma structures.
Beyond the diffraction limit with a quantum confinement effect (QCE) image sensor
Authors: Pavel E. , Marinescu V. 
Published: January 2024

The quantum confinement effect was successfully applied in quantum optical lithography
to pattern structures in 1–10 nm domain. In this paper, the
breakdown of the light diffraction limit was extended to optical
instruments (telescope and microscope). Optical writing of the QCE
image sensor was realized at a resolution of 60 nm. The novel,
to the best of our knowledge, type of the 1GPixel image sensor has
potential applications in (i) astronomy (angular resolution increases ∼240× at F/D = 24), and (ii)
optical microscopy (resolution ∼8nm at 660 nm). An optical
microscope with atomic resolution is proposed. Exceeding the light
diffraction limit, the theoretical growth of the angular resolution of
the telescope could attain an amplification factor of ∼14,000×.
Highly efficient, powerful Nd:YAG laser CW mode-locked with a monolayer CVD graphene saturable absorber mirror
Authors: Tereshchenko D. P. , Ershkov M. N. , Solokhin S. A. , Slukhov S. A. , Smetanin S. N. , Kochukov Yu. A. , Papashvili A. G. , Rybin M. G. , Ismaeel A. , Obraztsova E. D. 
Published: January 2024

Graphene-mode-locked solid-state lasers usually have a low optical efficiency (<10%) or a low output average power (<1W) due to losses in the graphene saturable absorber and the thermal load of the laser crystal. We demonstrate what we believe to our knowledge is an improved design for a highly efficient, powerful, diode-end-pumped Nd:YAG laser mode-locked with graphene. Internal losses of the laser cavity were minimized by using a high-quality monolayer graphene saturable absorber applied directly on the cavity end mirror. In comparison to other graphene-mode-locked solid-state lasers, the record high optical-to-optical and slope efficiencies of 19.1 and 24.5%, respectively, in a continuous wave mode-locking regime were achieved. The highest output average power was as high as 1.7 W for the ultrashort pulse repetition rate of 82 MHz at the beam quality of M2=1.3×1.4.
Exploring the resistance mechanism of triple-negative breast cancer to paclitaxel through the scRNA-seq analysis
Authors: Gao Wei , Sun Linlin , Gai Jinwei , Cao Yinan , Zhang Shuqun 
Published: January 2024

Background
The triple negative breast cancer (TNBC) is the most malignant subtype of breast cancer with high aggressiveness. Although paclitaxel-based chemotherapy scenario present the mainstay in TNBC treatment, paclitaxel resistance is still a striking obstacle for cancer cure. So it is imperative to probe new therapeutic targets through illustrating the mechanisms underlying paclitaxel chemoresistance.

Methods
The Single cell RNA sequencing (scRNA-seq) data of TNBC cells treated with paclitaxel at different points were downloaded from the Gene Expression Omnibus (GEO) database. The Seurat R package was used to filter and integrate the scRNA-seq expression matrix. Cells were further clustered by the FindClusters function, and the gene marker of each subset was defined by FindAllMarkers function. Then, the hallmark score of each cell was calculated by AUCell R package, the biological function of the highly expressed interest genes was analyzed by the DAVID database. Subsequently, we performed pseudotime analysis to explore the change patterns of drug resistance genes and SCENIC analysis to identify the key transcription factors (TFs). Finally, the inhibitors of which were also analyzed by the CTD database.

Results
We finally obtained 6 cell subsets from 2798 cells, which were marked as AKR1C3+, WNT7A+, FAM72B+, RERG+, IDO1+ and HEY1+HCC1143 cell subsets, among which the AKR1C3+, IDO1+ and HEY1+ cell subsets proportions increased with increasing treatment time, and then were regarded as paclitaxel resistance subsets. Hallmark score and pseudotime analysis showed that these paclitaxel resistance subsets were associated with the inflammatory response, virus and interferon response activation. In addition, the gene regulatory networks (GRNs) indicated that 3 key TFs (STAT1, CEBPB and IRF7) played vital role in promoting resistance development, and five common inhibitors targeted these TFs as potential combination therapies of paclitaxel were identified.

Conclusion
In this study, we identified 3 paclitaxel resistance relevant IFs and their inhibitors, which offers essential molecular basis for paclitaxel resistance and beneficial guidance for the combination of paclitaxel in clinical TNBC therapy.
Secuencia de Moebius-Poland
Authors: Urbina Villarraga Jaime , Cañas Cantillo Karen Paola , Quiroga Rey Adrina , Sanclemente Arias Diana Marcela , Lora Vidal Liliana Eugenia 
Published: January 2024

Antecedentes: la secuencia Moebius Poland, definida por la presencia conjunta de parálisis facial uni o bilateral, agenesia o hipoplasia del pectoral mayor y pezón, además de simbraquidactilia ipsilateral a la lesión del pectoral, es muy infrecuente. El último reporte en Colombia reportado en la literatura local fue de 2012 en la ciudad de Barranquilla, Colombia. Reporte de caso: Recién nacido masculino, embarazo con control prenatal irregular de inicio tardío. La madre niega consumo de fármacos o drogas psicoactivas. Las ecografías prenatales no reportaron deformidades o malformaciones, sin antecedente de infecciones perinatales. Parto espontáneo, eutócico, sin complicaciones, adecuada adaptación neonatal. Se aprecia parálisis facial y defecto de pared torácica. Conclusiones: Por tratarse de una condición de baja frecuencia se presenta el reporte de caso. La importancia de un diagnóstico temprano permite definir lesiones o malformaciones asociadas e intervención oportuna para definir un plan de tratamiento y rehabilitación temprana.
On the design of unconventional testing machines for engineering testing – the case study of advanced joining processes unit
Authors: Tenreiro António Francisco G. , Carbas Ricardo J. C. , Marques Eduardo A. S. , da Silva Carlos M. , Lopes António M. , da Silva Lucas F. M. 
Published: January 2024

Abstract
Structural adhesive joining has become a widely used joining method for various types of structures, thus avoiding more conventional joining methods. In this manner, adhesive materials may be present in structures which suffer loading conditions that may not be normally considered in the design phase, such as high-strain rate conditions or creep and torsional loading. In these situations, adhesive properties and mechanical behaviour are sometimes not well understood, thus requiring special machine testing setups that can only be built for the specific application. Therefore, this paper provides a brief overview of proposed machine architectures for a torsion testing apparatus, a tensile & compressive Split Hopkinson Pressure Bar (SHPB), a drop-weight apparatus and a three station creep testing machine with a climactic chamber. Each testing apparatus has been designed by graduate students during their master thesis projects, and facilitated in the production of interesting and relevant scientific output in the field of structural adhesive behaviour.