bluuebunny/crossref_metadata_2025_split huggingface dataset:
Flualprazolam and flubromazolam: Blood concentrations and prevalence of two novel psychoactive substances in forensic case work in Ontario, Canada
Authors: Vekic Nella , Armstrong-Price Delaney , Woodall Karen 
Published: November 2023

Abstract
Flualprazolam and flubromazolam are synthetic benzodiazepines that have not been approved for use in humans. They are categorized as novel psychoactive substances (NPS), and have been increasingly encountered in forensic case work. This report examines information from cases analyzed for flualprazolam and flubromazolam between July 1 and December 31, 2021 to identify the prevalence, trends and demographic data associated with these novel drugs in Ontario, Canada. Flualprazolam was identified in blood, serum or liver in 395 death investigations, 108 impaired driving and five sexual assault cases. Among all case types, blood concentrations were determined in 123 individuals aged 19–66 years. In impaired driving and sexual assault cases, flualprazolam blood concentrations ranged from &lt;1.3 to 227 ng/mL (median 11.0 ng/mL), whereas a range of 3–59 ng/mL (median 6.8 ng/mL) was reported in death investigations. Flubromazolam was identified in blood, serum or liver in 137 death investigations, 55 impaired driving and one sexual assault case. Blood concentrations ranged from &lt;1.3 to 323 ng/mL in 65 individuals, aged 14–61 years. In impaired driving and sexual assault cases, flubromazolam blood concentrations ranged from &lt;1.3 to 323 ng/mL (median 7.7 ng/mL), which overlapped with the range of 2–220 ng/mL (median 8.0 ng/mL) reported in death investigations. Other drugs were frequently detected with flualprazolam and flubromazolam with opioids identified in more than 89% of positive flualprazolam and flubromazolam cases. These results demonstrated the prevalence of flualprazolam and flubromazolam in Ontario, Canada. Trends showed that over the 6-month period, as the number of flubromazolam cases decreased, the incidences of flualprazolam increased. An overlap in concentrations of these drugs was observed in both death investigations and cases involving living individuals. These data provide valuable information for the scientific community regarding the use of these drugs in antemortem and postmortem casework.
Does preoperative gabapentin or intraoperative ketorolac influence postoperative pain following hip arthroscopy?
Authors: Meyer Alex M , Petrachaianan Krit , Glass Natalie A , Westermann Robert W 
Published: November 2023

ABSTRACTOptimization of perioperative analgesia has important implications for patient satisfaction and short-term outcomes. This study’s purpose is to assess if preoperative gabapentin or intraoperative ketorolac influences postoperative pain or time to discharge following hip arthroscopy. In total, 409 patients who underwent hip arthroscopic femoroplasty and/or acetabuloplasty with a single surgeon for femoroacetabular impingement were retrospectively reviewed (September 2017 to February 2021). The effect of preoperative gabapentin or intraoperative ketorolac on postoperative visual analog scale (VAS) pain scores, perioperative opioids in morphine milligram equivalents (MMEs), time in post-anesthesia care unit (PACU), second-stage recovery and time to discharge was assessed using unadjusted and adjusted t-tests, and generalized linear models controlling for operative time, traction time, preoperative MME, intraoperative MME and postoperative MME were compared between the groups of gabapentin to no gabapentin and ketorolac to no ketorolac. There was no difference in first PACU VAS pain score, final PACU VAS score, VAS pain score prior to discharge, average VAS pain score or pain level on follow-up call in the unadjusted or adjusted analysis for the preoperative gabapentin or intraoperative ketorolac groups. Females had higher first PACU VAS pain score (6.05 versus 5.15 P = 0.0026), final PACU VAS pain score (4.43 versus 3.90, P = 0.0045), final VAS pain score prior to discharge (3.87 versus 3.03, P &lt; 0.001) and average postoperative pain score (4.60 versus 4.03, P &lt; 0.001), but no difference in VAS pain score on follow-up call following surgery. Gabapentin or ketorolac was not associated with decreased VAS pain scores or time to discharge after hip arthroscopy.
Unifying Estimation and Inference for Linear Regression with Stationary and Integrated or Near-Integrated Variables
Authors: Hong Shaoxin , Henderson Daniel J , Jiang Jiancheng , Ni Qingshan 
Published: November 2023

Abstract
There is a discrepancy in the limiting distributions of least-squares estimators for stationary and integrated variables. For statistical inference, it must be decided which distribution should be used in advance. This motivates us to develop a unifying inference procedure based on weighted estimation. The asymptotic distributions of the proposed estimators are developed and a random weighting bootstrap method is proposed for constructing confidence regions. The proposed method outperforms existing methods (with time constant or time-varying error variance) in simulations. We further study the predictability of asset returns in a setting where some of our state variables are endogenous.
Single-cell transcriptomics reveals tumor-infiltrating B cell function after neoadjuvant pembrolizumab and chemotherapy in non-small cell lung cancer
Authors: Hou Lingjie , Zhang Siyuan , Yu Wenwen , Yang Xuena , Shen Meng , Hao Xishan , Ren Xiubao , Sun Qian 
Published: November 2023

Abstract
Non-small cell lung cancer (NSCLC) is the most pervasive lung cancer subtype. Recent studies have shown that immune checkpoint inhibitors achieved favorable clinical benefits in resectable NSCLC; however, the associated mechanism remains unclear. The role of T cells in antitumor immunity has received considerable attention, while the antitumor effects of tumor-infiltrating B cells (TIBs) in NSCLC remain poorly understood. Here, we conducted a single-cell RNA sequencing analysis of immune cells isolated from 12 patients with stage IIIA NSCLC to investigate B cell subtypes and their functions following neoadjuvant chemoimmunotherapy. We confirmed the simultaneous existence of the 4 B cell subtypes. Among them, memory B cells were found to be associated with a positive therapeutic effect to neoadjuvant chemoimmunotherapy. Furthermore, we found that G protein–coupled receptor 183 was most prevalent in memory B cells and associated with a positive therapeutic response. Multiplex immunofluorescence and flow cytometry experiments in an additional cohort of 22 treatment-naïve and 30 stage IIIA/IIIB NSCLC patients treated with neoadjuvant chemoimmunotherapy verified these findings. Overall, our analysis revealed the functions of TIBs and their potential effect on clinical treatment in NSCLC.
Systematic symptom management in the IMPACT Consortium: rationale and design for 3 effectiveness-implementation trials
Authors: Smith Ashley Wilder , DiMartino Lisa , Garcia Sofia F , Mitchell Sandra A , Ruddy Kathryn J , Smith Justin D , Wong Sandra L , Cahue September , Cella David , Jensen Roxanne E , Hassett Michael J , Hodgdon Christine , Kroner Barbara , Osarogiagbon Raymond U , Popovic Jennifer , Richardson Kimberly , Schrag Deborah , Cheville Andrea L ,   IMPACT Consortium, Cella David , Cheville Andrea , Hassett Michael J , Osarogiagbon Raymond U , Schrag Deborah , Wong Sandra L , Kroner Barbara L , Smith Ashley Wilder , DiMartino Lisa , Garcia Sofia , Griffin Joan , Jensen Roxanne , Mitchell Sandra , Ruddy Kathryn , Smith Justin D , Yanez Betina , Bian Jessica J , Dizon Don S , Hazard-Jenkins Hannah W , Ardini Mary-Anne , Ahrens Paige , Austin Jessica , Barrett Fiona , Bass Michael , Begnoche Megan , Cahue September , Caron Kimberly , Chlan Linda , Coughlin Ava , Cronin Christine , Dias Samira , Farisiv Nicolas , Flores Anne Marie , Garcia Martha , Hemming Karla , Herrin Jeph , Hodgdon Christine , Kircher Sheetal , Kroenke Kurt , Lam Veronica , Lancki Nicola , Mai Quan H , Mallow Jennifer , McCleary Nadine J , Norton Wynne , O'Connor Mary , Pachman Deirdre , Pearsonil Loretta , Penedo Frank , Podratz Jewel , Popovic Jennifer , Preiss Liliana , Rahman Parvez , Redmond Sarah , Reich James , Richardson Joshua , Richardson Kimberly , Ridgeway Jennifer , Rutten Lila , Schaepe Karen , Scholtens Denise , Poirier-Shelton Tiana , Silberman Philip , Simpson Jaclyn , Tasker Laura , Tesch Nathan , Tofthagen Cindy , Tramontano Angela , Tyndall Benjamin D , Uno Hajime , Wehbe Firas , Weiner Bryan 
Published: November 2023

AbstractCancer and its treatment produce deleterious symptoms across the phases of care. Poorly controlled symptoms negatively affect quality of life and result in increased health-care needs and hospitalization. The Improving the Management of symPtoms during And following Cancer Treatment (IMPACT) Consortium was created to develop 3 large-scale, systematic symptom management systems, deployed through electronic health record platforms, and to test them in pragmatic, randomized, hybrid effectiveness and implementation trials. Here, we describe the IMPACT Consortium’s conceptual framework, its organizational components, and plans for evaluation. The study designs and lessons learned are highlighted in the context of disruptions related to the COVID-19 pandemic.
Emerging Signals of Change that Could Shape the Future of Forestry: a Horizon Scan
Authors: Bengston David N , Westphal Lynne M , Adelson Paul , Crabtree Jason , Dockry Michael J , Hines Andy , Kubik George H , Romero Maria , Van Stanley Zach , Zimmerman Nicole L 
Published: November 2023

Abstract
Foresight is essential for long-term planning and forward-looking decision-making in forestry, where planning horizons often span many decades. But generating foresight is challenging due to the increasing pace and complexity of change and growing uncertainty about the future. Most change that could affect or even disrupt forestry in the future originates outside of the field, such as social, technological, economic, and environmental changes. The Forest Futures Horizon Scanning project (Forest Horizons) aims to generate foresight by identifying early signals of change from outside forestry that professionals within the field may not be aware of or pay close attention to. This article draws on the database of signals of change uncovered in the Forest Horizons project and identifies fifteen key emerging changes that could help shape the long-term future of forestry.
Study Implications: The long-term nature of forestry has compelled foresters to be forward-looking and plan many decades ahead. Horizon scanning is a tool that can enhance foresight in forestry by identifying emerging signals of change that could affect the field in the future. Fifteen wide-ranging early signals of change are highlighted in this article. Consideration of these emerging changes in long-term and strategic planning could help forestry decision makers prepare for change and avoid being blindsided. Horizon scanning is a useful approach to help generate essential foresight in an era of increasingly rapid, complex, and often surprising change.
Inclusion, democracy, and philosophy of education: Nuraan Davids and Yusef Waghid's Democratic education as inclusion
Authors: Enslin Penny 
Published: November 2023

Abstract
For philosophers of education who hold on to the optimistic hope that democracy education can play a part in halting the decline of democracy, Davids and Waghid point the way towards its potential contribution when approached by making inclusion foundational to democratic education. Taking a poststructuralist approach as the best way to articulate an expanded conception of inclusion, this book makes the case that there is an urgent need for a reconsidered conception of democratic education that appropriately addresses race, ethnicity and gender. This review's critical appreciation of Davids and Waghids book explores their analysis of inclusion, noting its illuminating use of examples of exclusion in South African education which are also relevant to wider contexts beyond the specificities of apartheid and post-apartheid South Africa. In raising some questions about their arguments, I express reservations about the book's predominant focus on race, ethnicity and gender as markers of identity. This is at the expense of class and material exclusion—and hence of distributive justice as a dimension of democratic inclusion. The review concludes with a discussion of how philosophy of education itself might be democratically inclusive, in response to the authors' account of whiteness and their experiences of exclusion.
An unusual case of B-cell lymphoma of the scalp
Authors: Chaudhry Nadeem , Qureshi Abid , Gollamudi Sindhuri , Kasbawala Kinjal , Clopton Brittni J , Moore Colton , Genato Romulo , Xiao Philip , Asarian Armand 
Published: November 2023

Abstract
B-cell lymphoma is a lymphoproliferative non-Hodgkin lymphoma arising from B cells, a type of immune lymphocytes that produces antibodies in the follicles of lymph nodes. Primary cutaneous B-cell lymphoma (PCBCL), a subtype of B cell lymphoma, originates within cutaneous tissue without evidence of extracutaneous involvement. There are very few reports of PCBCLs originating in the scalp. The most common tumors of the scalp are usually benign with only 1%–2% being malignant, most being basal cell carcinoma, squamous cell carcinoma, or melanoma. Primary cutaneous follicular cell lymphoma (PCFCL) is regarded as the most common lymphoma of the skin with an indolent course and favorable prognosis due to the response rate to treatment methods such as surgical removal with local radiotherapy, topical drugs, and intralesional therapies. This report highlights a rare case of PCFCL originating in the scalp, to raise awareness of a topic that requires continued established management.
“I didn’t know there were so many kinds of people and so many sorts of provincialism in the world’’: Tracking Provincialism Through the Nineteenth-Century Corpus
Authors: O’Neill Helen Anne 
Published: November 2023

Abstract
Beginning with a full text search for the term ‘provincialism’ across all entries in the OED Online, this article tracks ‘provincialism’ through the digitized fiction of the nineteenth century, eavesdropping on the ways in which the term was used in a dataset of references drawn from 165 nineteenth-century novels brought together from the British Library 19th Century Collection and the Hathi Trust Digital Library. The focus is not on a close reading of a small number of novels, a novel subgenre, or iterations of a single novel, but on a close reading of multiple short, references to the term ‘provincialism’ drawn from a large number of nineteenth-century digitized novels. Attention is concentrated on the textually small, the fleeting yet potent uses of the term deployed by nineteenth-century novelists writing in a mass cultural medium with a local and global reach. The findings offer up a relational and multidimensional picture of the term aggregated from the textually small, as it plays out in relation to class, gender, the city, the four nations of the UK, the British Empire and the wider world.
Pediatric Obesity Prevalence in the U.S. Military Health System, Fiscal Years 2012-2018
Authors: Bleach Cortney C , Brooks Daniel I , Larson Noelle S 
Published: November 2023

ABSTRACT

Introduction
Obesity prevalence in Military Health System (MHS) children has been reported through fiscal year (FY) 2012 as consistently lower than in the general population. Our study reports military pediatric overweight, obesity, and severe obesity prevalence through FY2018. We compared FY2018 prevalence to a sample of the general population using National Health and National Health and Nutrition Examination Survey (NHANES) 2017-2018 data.

Materials and methods
The MHS Data Repository was queried for all children aged 2-17 years seen at any military treatment facility between FY2012 and FY2018. We calculated overweight and obesity (classes 1, 2, and 3) prevalence for each FY and performed subgroup analysis for sex, age, and sponsor rank. We also compared FY2018 to NHANES 2017-2018 data. This study was approved by the Walter Reed National Military Medical Center Institutional Review Board.

Results
The prevalence of overweight and obesity was stable from FY2012 (14.4% and 11.3%, respectively) to FY2018 (14.1% and 10.7%). Rates of classes 2 and 3 obesity combined were also stable at around 2.5% of all children. In FY2018, obesity prevalence was greater in assigned males, increased with age, and was highest in 16-17-year-olds (odds ratio: 2.75) and children with an enlisted military sponsor (odds ratio: 1.78). Compared to NHANES, MHS children had lower rates of obesity (10.7% versus 19.3%) with a smaller proportion of severe obesity (24% versus 32%).

Conclusions
The prevalence of pediatric overweight and obesity in the MHS was stable over time. Disparities were observed between age and sponsor rank groups. When compared to the general population, overall obesity prevalence was lower in younger military children. Further research is needed to explore disparities and to identify optimal strategies to mitigate the increase in obesity prevalence with age.
Occurrence of Aspergillus fumigatus azole resistance in soils from Switzerland
Authors: Schürch Stéphanie , Gindro Katia , Schnee Sylvain , Dubuis Pierre-Henri , Codina Josep Massana , Wilhelm Matthieu , Riat Arnaud , Lamoth Frédéric , Sanglard Dominique 
Published: November 2023

Abstract
Aspergillus fumigatus is a fungal species causing diverse diseases in humans. The use of azoles for treatments of A. fumigatus diseases has resulted in azole resistance. Azoles are also widely used in the environment for crop protection, which resulted in azole resistance. Resistance is primarily due to mutations in cyp51A, which encodes the target protein for azoles. Here we addressed the occurrence of azole resistance in soils from a vast part of Switzerland. We aimed to associate the use of azoles in the environment with the occurrence of azole resistance. We targeted sample sites from different agricultural environments as well as sites with no agricultural practice (natural sites and urban sites). Starting from 327 sites, 113 A. fumigatus isolates were recovered (2019–2021), among which 19 were azole-resistant (15 with TR34/L98H and four with TR46/Y121F/T289A resistance mutations in cyp51A). Our results show that azole resistance was not associated with a specific agricultural practice. Azoles could be chemically detected in investigated soils, however, their presence was not associated with the occurrence of azole-resistant isolates. Interestingly, genetic markers of resistance to other fungicides were detected but only in azole-resistant isolates, thus reinforcing the notion that A. fumigatus cross-resistance to fungicides has an environmental origin.
In conclusion, this study reveals the spreading of azole resistance in A. fumigatus from the environment in Switzerland. The proximity of agricultural areas to urban centers may facilitate the transmission of resistant strains to at-risk populations. Thus, vigilant surveillance is required to maintain effective treatment options for aspergillosis.
The High Time Resolution Universe Pulsar survey – XVIII. The reprocessing of the HTRU-S Low Lat survey around the Galactic Centre using a Fast Folding Algorithm pipeline for accelerated pulsars
Authors: Wongphechauxsorn J , Champion D J , Bailes M , Balakrishnan V , Barr E D , Bernadich M C i , Bhat N D R , Burgay M , Cameron A D , Chen W , Flynn C M L , Jameson A , Johnston S , Keith M J , Kramer M , Ng C , Possenti A , Sengar R , Shannon R M , Stappers B , van Straten W 
Published: November 2023

ABSTRACT
The HTRU-S Low Latitude survey data within 1° of the Galactic Centre (GC) were searched for pulsars using the Fast Folding Algorithm (FFA). Unlike traditional Fast Fourier Transform (FFT) pipelines, the FFA optimally folds the data for all possible periods over a given range, which is particularly advantageous for pulsars with low-duty cycles. For the first time, a search over acceleration was included in the FFA to improve its sensitivity to binary pulsars. The steps in dispersion measure (DM) and acceleration were optimized, resulting in a reduction of the number of trials by 86 per cent. This was achieved over a search period range from 0.6 to 432-s, i.e. 10 per cent of the observation time (4320s), with a maximum DM of 4000 pc cm−3 and an acceleration range of ±128 m s−2. The search resulted in the re-detections of four known pulsars, including a pulsar that was missed in the previous FFT processing of this survey. This result indicates that the FFA pipeline is more sensitive than the FFT pipeline used in the previous processing of the survey within our parameter range. Additionally, we discovered a 1.89-s pulsar, PSR J1746-2829, with a large DM, located 0.5 from the GC. Follow-up observations revealed that this pulsar has a relatively flat spectrum (α = −0.9 ± 0.1) and has a period derivative of ∼1.3 × 10−12 s s−1, implying a surface magnetic field of ∼5.2 × 1013 G and a characteristic age of ∼23 000 yr. While the period, spectral index, and surface magnetic field strength are similar to many radio magnetars, other characteristics such as high linear polarization are absent.
MIGHTEE: Multi-wavelength counterparts in the COSMOS field
Authors: Whittam I H , Prescott M , Hale C L , Jarvis M J , Heywood I , An Fangxia , Glowacki M , Maddox N , Marchetti L , Morabito L K , Adams N J , Bowler R A A , Hatfield P W , Varadaraj R G , Collier J , Frank B , Taylor A R , Santos M G , Vaccari M , Afonso J , Ao Y , Delhaize J , Knowles K , Kolwa S , Randriamampandry S M , Randriamanakoto Z , Smirnov O , Smith D J B , White S V 
Published: November 2023

ABSTRACT
In this paper, we combine the Early Science radio continuum data from the MeerKAT International GHz Tiered Extragalactic Exploration (MIGHTEE) Survey, with optical and near-infrared data and release the cross-matched catalogues. The radio data used in this work covers 0.86 deg2 of the COSMOS field, reaches a thermal noise of 1.7 μJy beam−1 and contains 6102 radio components. We visually inspect and cross-match the radio sample with optical and near-infrared data from the Hyper Suprime-Cam (HSC) and UltraVISTA surveys. This allows the properties of active galactic nuclei and star-forming populations of galaxies to be probed out to z ≈ 5. Additionally, we use the likelihood ratio method to automatically cross-match the radio and optical catalogues and compare this to the visually cross-matched catalogue. We find that 94 per cent of our radio source catalogue can be matched with this method, with a reliability of 95 per cent. We proceed to show that visual classification will still remain an essential process for the cross-matching of complex and extended radio sources. In the near future, the MIGHTEE survey will be expanded in area to cover a total of ∼20 deg2; thus the combination of automated and visual identification will be critical. We compare the redshift distribution of SFG and AGN to the SKADS and T-RECS simulations and find more AGN than predicted at z ∼ 1.