bluuebunny/crossref_metadata_2025_split huggingface dataset:
Supernatant of activated platelet-rich plasma rejuvenated aging-induced hyposalivation in mouse
Authors: Kim Sungryeal , Kim Jeong Mi , Jeon Eun Jeong , Kim Ji Won , Choi Mi Eun , Park Jin-Mi , Choi Jeong-Seok 
Published: December 2023

AbstractHyposalivation is a common complaint among the elderly, but no established treatment prevents age-induced hyposalivation. Platelet derivatives such as platelet-rich plasma (PRP), platelet-rich fibrin (PRF), and plasma rich in growth factor (PRGF), are used widely in different areas of regenerative medicine to enhance the wound healing processes. This study examined whether the local injection of the supernatant of activated PRP (saPRP) into the salivary gland (SG) could help prevent aging-induced SG dysfunction and explored the mechanisms responsible for the protective effects on the SG hypofunction. The platelets were separated from the blood of male SD rats (220 ± 20 g). saPRP was manufactured by removing the fibrin clot after activating platelet with calcium ionophore 10 μM (A23187). The total protein and TGF-β1 levels were significantly higher in saPRP than in PRP. Human salivary gland epithelial cell(hSGEC) was treated with saPRP or PRP after senescence through irradiation. The significant proliferation of hSGEC was observed in saPRP treated group compared to irradiation only group and irradiation + PRP group. Cellular senescence, apoptosis, and inflammation significantly reduced in saPRP group. The SG function and structural tissue remodeling by the saPRP were investigated with naturally aged mice. The mice were divided into three groups: 3 months old (3 M), 22 months old (22 M), and 22 months old treated with saPRP (22 M + saPRP). Salivary flow rate and lag time were significantly improved in 22 M + saPRP group compared to 22 M group. The histologic examinations showed the significant proliferation of acinar cell in 22 M + saPRP group. The decrease of senescence, apoptosis, and inflammation observed by western blot in 22 M + saPRP group. The saPRP induced the proliferation of hSGECs, leading to a significant decrease in cellular senescence via decrease inflammation and apoptosis, in vitro. Moreover, the acini cells of the salivary gland were regenerated, and the salivary function increased in aged mice. These results showed that saPRP could be a treatment agent against aging-induced SG dysfunction.
Epidemiology and genetic diversity of Streptococcus suis in smallhold swine farms in the Philippines
Authors: Sedano Susan A. , Cantalejo Mary Grace Concepcion T. , Lapitan Christine Grace Angela R. , de Guzman Angelo Miguel Elijah S. , Consignado Jennielyn T. , Tandang Nancy A. , Estacio Maria Amelita C. , Kerdsin Anusak , Silva Benji Brayan Ilagan 
Published: December 2023

AbstractThis study aimed to determine the presence and characteristics of locally circulating strains of Streptococcus suis, the most important streptococcal pathogen in swine. Oral swab samples were collected from pigs from 664 representative smallhold farms across nine provinces in the Philippines. Isolates were identified and characterized using PCR assays. The study revealed an isolation rate of 15.8% (105/664, 95% CI: 13.0–18.6) among the sampled farms. Two hundred sixty-nine (269) S. suis isolates were recovered from 119 unique samples. Serotype 31 was the most prevalent (50/269, 95% CI: 13.9–23.2) among the other serotypes identified: 5, 6, 8, 9, 10, 11, 15, 16, 17, 21, 27, 28, and 29. The detection of the three ‘classical’ S. suis virulence-associated genes showed that 90.7% (244/269, 95% CI: 87.2–94.2) were mrp-/epf-/sly-. Multilocus sequence typing (MLST) analysis further revealed 70 novel sequence types (STs). Notably, several local isolates belonging to these novel STs formed clonal complexes (CC) with S. suis strains recovered from Spain and USA, which are major pork-exporting countries to the Philippines. This study functionally marks the national baseline knowledge of S. suis in Philippines.
Proton pump inhibitors and chronic kidney disease risk: a comparative study with histamine-2 receptor antagonists
Authors: Kweon Takhyeon , Kim Yerim , Lee Kyung Joo , Seo Won-Woo , Seo Seung In , Shin Woon Geon , Shin Dong Ho 
Published: December 2023

AbstractThis observational study explored the association between proton pump inhibitor (PPI) and histamine-2 receptor antagonist (H2RA) use and the risk of chronic kidney disease (CKD). Using the National Health Insurance Service-National Sample Cohort (NHIS-NSC) and six-hospital electronic health record (EHR) databases, CKD incidence was analyzed among PPI and H2RA users. Propensity score matching was used to balance baseline characteristics, with 1,869 subjects each in the PPI and H2RA groups from the NHIS-NSC, and 5,967 in EHR databases. CKD incidence was similar for both groups (5.72/1000 person-years vs. 7.57/1000 person-years; HR = 0.68; 95% CI, 0.35–1.30). A meta-analysis of the EHR databases showed no significant increased CKD risk associated with PPI use (HR = 1.03, 95% CI: 0.87–1.23). These results suggest PPI use may not increase CKD risk compared to H2RA use, but the potential role of PPI-induced CKD needs further research. Clinicians should consider this when prescribing long-term PPI therapy.
Fostering sustainable investments through micro-investing platforms
Authors: Gonzalez-Arcos Claudia , Meath Cristyn , Leszczyc Peter Popkowski , Haruvy Ernan , An Jake 
Published: December 2023

AbstractWe uncover the underlying factors that influence perceived trade-offs between sustainability and financial returns and risks, and the resulting real-world investment behaviour of micro-investors. Given the direct-to-consumer nature of new age investment platforms, the context for our study is framed within a consumer-centric context. Through a survey and conjoint experiment (383 investors), and analysis of actual investment decisions (for 89,744 micro-investors), we show that individual motives—specifically sustainability values and feelings of empowerment—are key drivers for sustainable investments, influencing willingness to forgo financial returns and the duration of investment. We provide practical implications for fostering sustainable investments through micro-investing platforms.
Identification of differentially expressed circRNAs in prostate cancer of different clinical stages by RNA sequencing
Authors: Wang Xing , Huang Ruizhen , Yu Juhui , Zhu Fei , Xi Xiaoqing , Huang Yawei , Zhang Chiyu , Hu Honglin 
Published: December 2023

AbstractCircular RNAs (circRNAs) are linked to cancer, but it's still not clear what role they play in prostatic cancer. Through high-throughput sequencing, the goal of this study was to compare how circRNAs are expressed at different stages of prostate cancer. 12 patients attending the Department of Urology at the Second Affiliated Hospital of Nanchang University between June 2020 and October 2021 were used for RNA sequencing, and 14 patients were used for real-time fluorescent quantitative PCR (qRT-PCR). The expression profiles of prostate cancer circRNAs were constructed by sequencing with the help of next-generation high-throughput sequencing technology, and the differentially expressed circRNAs were analyzed by targeting microRNA (miRNA) loci and Gene Ontology (GO) enrichment analysis and Kyoto Encyclopedia of Genes and Genomes (KEGG) enrichment analysis of the genes from which circRNAs originated. Finally, the expression of target circRNAs in two prostate tissues was verified by qRT-PCR. Following high-throughput sequencing, 13,047 circRNAs were identified, and 605 circRNAs with significant differential expression were identified, of which 361 circRNAs were up-regulated, and 244 circRNAs were down-regulated. Analysis of circRNA-originated genes using GO and the KEGG enrichment analysis showed that circRNA host genes can regulate and influence multiple signaling pathways in prostate cancer with important biological functions. And the circRNA–miRNA network was constructed. The highest number of differentially expressed circRNA-binding miRNAs were: hsa_circ_000 7582 (52), hsa_circ_000 6198 (37), hsa_circ_000 6759 (28), hsa_circ_000 5675 (25), and hsa_circ_000 2172 (22). Moreover, we further screened out the circRNA (hsa_circ_0005692) that was significantly differentially expressed and common to all groups and verified by qRT-PCR that the expression of the target circRNA (hsa_circ_0005692) was significantly downregulated in prostate cancer compared with benign prostatic hyperplasia (BPH) tissues.
Efficient generation of brain organoids using magnetized gold nanoparticles
Authors: Kim Hongwon , Lee Yoo-Jung , Kwon Youngeun , Kim Jongpil 
Published: December 2023

AbstractBrain organoids, which are three-dimensional cell culture models, have the ability to mimic certain structural and functional aspects of the human brain. However, creating these organoids can be a complicated and difficult process due to various technological hurdles. This study presents a method for effectively generating cerebral organoids from human induced pluripotent stem cells (hiPSCs) using electromagnetic gold nanoparticles (AuNPs). By exposing mature cerebral organoids to magnetized AuNPs, we were able to cultivate them in less than 3 weeks. The initial differentiation and neural induction of the neurosphere occurred within the first week, followed by maturation, including regional patterning and the formation of complex networks, during the subsequent 2 weeks under the influence of magnetized AuNPs. Furthermore, we observed a significant enhancement in neurogenic maturation in the brain organoids, as evidenced by increased histone acetylation in the presence of electromagnetic AuNPs. Consequently, electromagnetic AuNPs offer a promising in vitro system for efficiently generating more advanced human brain organoids that closely resemble the complexity of the human brain.
Zingiber zerumbet: A Scoping Review of its Medicinal Properties
Authors: Chan Janice Sue Wen , Lim Xin Yi , Japri Norfarahana , Ahmad Ida Farah , Tan Terence Yew Chin 
Published: December 2023

Abstract
Zingiber zerumbet, a plant native to tropical and subtropical Asia, has a vast range of traditional uses and has been continuously studied for its medicinal properties. However, a
systematic methodological approach in evidence synthesis on the plantʼs efficacy is lacking, and there is a need to elicit the current research status of this plant. This scoping review was
conducted to systematically explore and collate the available scientific evidence on the efficacy of Z. zerumbet and its main phytoconstituents in various formulations, their
biological mechanisms, and their safety. Results included 54 articles consisting of animal studies, while there were no published human studies. Only half of the included studies provided
adequate reporting on the quality-related details of Z. zerumbet formulations. Identified pharmacological activities were analgesic, anti-inflammatory, anti-diabetic,
anti-hyperlipidemic, anti-neoplastic, immunomodulatory, antioxidant, antipyretic, hepatoprotective, nephroprotective, gastroprotective, and locomotor-reducing activities. Notably, the
ethanolic extract of Z. zerumbet was found to be well tolerated for up to 28 days. In conclusion, Z. zerumbet and zerumbone have various pharmacological effects, especially in
analgesic and anti-inflammatory models. However, there is still a pressing need for comprehensive safety data to conduct clinical trials.
The Italian colour lexicon in Tuscany: elicited lists, cognitive salience, and semantic maps of colour terms
Authors: Del Viva Maria Michela , Castellotti Serena , Paramei Galina V. 
Published: December 2023

AbstractWe investigated the Tuscan Italian colour inventory, with the aim of establishing the cognitive salience of the basic colour terms (BCTs) and most frequent non-BCTs. Native speakers from Tuscany (N = 89) completed a colour-term elicitation task lasting for 5 min. In total, 337 unique terms were elicited, with an average list length of 30.06. The frequency of each term, its mean list position and cognitive salience index (S) were calculated. The CTs with the highest S (ranked 1–13) included 10 counterparts of the Berlin and Kay BCTs listed in their 1969 seminal work and three basic ‘blue’ terms, blu, azzurro, celeste, estimated for Tuscan respondents by Del Viva et al. in 2022. S-index and Zipf-function (the terms’ “popularity”) indicated that fucsia (rank 14) is conceivably an emerging BCT in (Tuscan) Italian. Other cognitively salient non-BCTs are lilla, magenta, ocra and beige. The terms’ 3D semantic map (conceptual closeness), assessed using multidimensional scaling and cluster analysis, revealed that in the lists, closely associated CTs were arranged along three competing criteria: the term’s salience gradient; word length; and clustering of fully chromatic concepts with those defined primarily by lightness or desaturation. We also consider salient Italian non-BCTs as indicators of the ongoing process of lexical refinement in certain areas of the colour space. In conclusion, measures of elicitation productivity, as well as the augmented BCT inventory, including the Tuscan ‘triple blues’, and abundant hyponyms and derived forms all indicate (Tuscan) Italian speakers’ “cultural competence” in the colour domain and the need to communicate nuanced information about colour shades.
Design and experiments of a compact electrostatic low energy beam transport with a double Einzel-lens for a transportable neutron source
Authors: Li H. P. , Liu C. , Luo H. , Wang F. Y. , Su H. Q. , Wang S. , Wu Q. 
Published: December 2023

A transportable, compact, accelerator-based neutron source is under development at Xian Jiaotong University. An electrostatic low energy beam transport (LEBT) structure with a double Einzel-lens setup was adopted due to its short length and low power consumption. It can transport a pulsed proton beam to the radio frequency quadrupole with a required beam current of 15 mA and an energy of 30 keV. We performed detailed structure optimization and beam tracking to achieve beam matching and small emittance growth. In addition, the fast chopper, beam steering, and diagnostic devices are integrated into the LEBT. The fabrication and assembly of the proton injector have been completed, and beam commissioning was carried out to measure the beam current and Twiss parameters. The design strategy, beam simulation, and experimental results are presented and discussed in this paper.
A review of the impacts and management of invasive plants in forestry
Authors: Jones Vanessa L. , Grenz Jennifer 
Published: December 2023

Abstract
While the impacts of invasive plants are commonly researched and described within the context of agriculture and restoration ecology, they receive less attention within the specific context of forestry. Forestry operations are both vulnerable to and could exacerbate the spread of invasive plants through all aspects of silviculture, all of which can lead to reduced profitability and negative impacts to the sustainability and resiliency of the ecosystems they operate within. The purpose of this review article was to synthesize the current academic and gray literature pertaining to invasive plants and forestry to inform prevention and management approaches and identify gaps in the research. We incorporated a case study from interviews with major forestry company professionals in British Columbia, Canada managing invasive species within their operations to provide critical and often overlooked perspectives and experiences. Our review provides key insights into the risks invasive plants pose to forest community and tree health, operations, economic value, and ecosystem health and identifies the need for research specific to the impacts of invasive plants and their management strategies within the context of forestry operations.
Validation of krypton as a new tracer gas for the standardization tests of collective and individual protection systems
Authors: Cabaset Elise , Marchal Mathieu , Santandrea Audrey , Herbinet Olivier , Belut Emmanuel , Lechêne Sullivan , Marsteau Stéphanie , Leclerc Jean-Pierre 
Published: December 2023

Abstract
Sulfur hexafluoride (SF6) is the reference tracer gas in many international standards for characterizing respiratory protective devices (RPD), fume cupboards, building ventilations, and other installations. However, due to its significant impact on global warming, its use is becoming increasingly restrictive. Krypton 84 (Kr) was chosen to be a possible replacement based on theoretical and practical criteria for the properties that a substitute gas should possess. While compliance with these criteria is generally sufficient to guarantee the reliability of the choice, it is essential in the case of widespread use such as a standard to validate experimentally that this tracer has the same behavior as SF6. In this regard, numerous tests have been carried out to characterize the face leakage of RPD and the rupture of containment of fume cupboards performance tests under different operating conditions. The results obtained are identical with both tracers and lead us to propose the use of Kr as a new reference gas in standards for which SF6 was used.
IBC-Oxford University2023_BJSPoster_5In The Era of “Sleeve Revision”, What is The Perfect Algorithm?: Suggested Algorithm with Review of the literature
Authors: Elemawy M , Abbas R F 
Published: December 2023

Abstract

Background
Laparoscopic sleeve gastrectomy (LSG) is the mainstream treatment option for patients with morbid obesity due to restrictive and endocrine mechanisms, however it requires modifications for a subset of patients because of weight regain and tough complications, such as gastroesophageal reflux, strictures, gastric leak, and persistent metabolic syndrome. Revision surgeries have become more and more indispensable in bariatric surgery, accounting for 7.4% in 2016.

Methods
A systematic literature search was performed in PubMed, Embase and Cochrane library. Data were collected and analysed.

Results
Revisional bariatric surgeries after LSG include Roux-en-Y gastric bypass, repeated sleeve gastrectomy, biliopancreatic diversion, duodenal switch, duodenal-jejunal bypass, one-anastomosis gastric bypass (MGB), single anastomosis duodeno-ileal bypass (SADI) and transit bipartition. The overall revision rate was 10.4%, but for patients with ≥ 10-year follow-up, the rate was 22.6%. European studies had a higher revision rate (14.4%) than other studies. The most common reason for revision was failure in weight loss, and the most frequent revisional procedure was gastric bypass.

Conclusion
Reaching a clear algorithm for revisional bariatric surgery is still debated. However, we assume that it depends mainly on pre-revisional BMI and presence of GERD symptoms as follows: patients with BMI&gt; 40 kg/m2 should receive Standard R-Y gastric bypass, those with BMI &lt; 40 kg/m2 with GERD should have R-Y gastric bypass with long biliopancreatic limb or MGB with RY configuration. Patients with BMI &lt; 40 kg/m2 without GERD may benefit from MGB or SADI
IBC-Oxford University2023_BJSPoster_17Bariatric Surgery on Patients with Epilepsy
Authors: Sargsyan N , Fehervari M , Al Shdefat S , Bonanomi G , Fakih-Gomez N 
Published: December 2023

Abstract

Introduction
Obesity is a common comorbid condition in patients with epilepsy, its occurrence is multifactorial and antiepileptic medications may contribute to the development of obesity and metabolic syndrome. Bariatric surgery can be offered to patients with epilepsy and obesity related comorbidities. Currently, there is lack of information regarding bariatric surgery on seizure control and antiepileptic drug concentration/toxicity.

Methods
A retrospective review of a local database was performed in a tertiary centre for Bariatric Surgery. All consecutive patients with epilepsy referred to the Bariatric MDT since 2010 were identified. Standard clinical data, postoperative complications, seizure frequency, antiepileptic therapy and weight loss were extracted.

Results
We identified 11 patients with epilepsy who underwent Bariatric Surgery (3 Sleeve gastrectomy, 4 gastric bypass, 4 gastric band). The %TWL 1 year after Bariatric Surgery (BS) was 22.4(20-24)%; 3 years following BS was 19.9(5-25)% and 5 years following BS was 18.9(4-24)%. 7 Patients remained seizure free during 5 year follow up after BS, in 3 people their seizure frequency did not change after BS and one patient had a cluster of dissociative seizures. There were no medication side effects reports due to impact of surgery.

Conclusion
Bariatric Surgery is a safe treatment option for individuals with epilepsy. The majority of patients with epilepsy who underwent bariatric surgery had no worsening in seizure frequency or experienced any medication side effects due to the impact of surgery on absorption. Individuals with morbid obesity and epilepsy can be considered for bariatric surgery. More research is required to adequately explore the impact of BS on patients with epilepsy.
Cost-effectiveness of Prefusion F Protein-based Vaccines Against Respiratory Syncytial Virus Disease for Older Adults in the United States
Authors: Moghadas Seyed M , Shoukat Affan , Bawden Carolyn E , Langley Joanne M , Singer Burton H , Fitzpatrick Meagan C , Galvani Alison P 
Published: December 2023

Abstract

Background
Two prefusion F protein-based vaccines, Arexvy and Abrysvo, have been authorized by the US Food and Drug Administration for protecting older adults against respiratory syncytial virus (RSV)-associated lower respiratory tract illness. We evaluated the health benefits and cost-effectiveness of these vaccines.

Methods
We developed a discrete-event simulation model, parameterized with the burden of RSV disease including outpatient care, hospitalization, and death for adults aged 60 years or older in the United States. Taking into account the costs associated with these RSV-related outcomes, we calculated the net monetary benefit using quality-adjusted life-year (QALY) gained as a measure of effectiveness and determined the range of price-per-dose (PPD) for Arexvy and Abrysvo vaccination programs to be cost-effective from a societal perspective.

Results
Using a willingness-to-pay of $95 000 per QALY gained, we found that vaccination programs could be cost-effective for a PPD up to $127 with Arexvy and $118 with Abrysvo over the first RSV season. Achieving an influenza-like vaccination coverage of 66% for the population of older adults in the United States, the budget impact of these programs at the maximum PPD ranged from $6.48 to $6.78 billion. If the benefits of vaccination extend to a second RSV season as reported in clinical trials, we estimated a maximum PPD of $235 for Arexvy and $245 for Abrysvo, with 2-year budget impacts of $11.78 and $12.25 billion, respectively.

Conclusions
Vaccination of older adults would provide substantial direct health benefits by reducing outcomes associated with RSV-related illness in this population.