bluuebunny/crossref_metadata_2025_split huggingface dataset:
Within-Person Associations Between Sexual Life And Relationship Satisfaction In Women With Mayer-Rokitansky-Kuster-Hauser Syndrome In Long-Term Relationships
Authors: Silveira Lídia , Dutra Natalia , Burti Juliana Schulze , Veloso Vivianni 
Published: February 2025

Abstract

Purpose: individuals with sexual dysfunctions represent a relevant population for relationship maintenance research because they explore how couples adapt to challenging circumstances. Once satisfaction plays a a crucial role in maintaining romantic relationships, with strong evidence indicating that sexual satisfaction significantly influences relationship satisfaction, investigating these adaptations provides valuable insights into the strategies couples employ to maintain relationships. This study investigates the dynamic between sexual life aspects and relationship satisfaction in women diagnosed with Mayer-Rokitansky-Küster-Hauser Syndrome (MRKH), a congenital condition characterized by the underdevelopment or absence of the uterus and vaginal canal.
Methods: An online survey was conducted with 34 women diagnosed with MRKH (RG) and 80 women without the condition (CG). Clinical, sociodemographic, and behavioral data were collected, including relationship characteristics, sexual practices, sexual functioning, and emotional attachment to partners. Correlation analyses were used to assess the relationship between sexual satisfaction and relationship satisfaction while controlling relationship duration, parenthood, age, educational attainment, and socioeconomic status.
Results: for RG, relationship satisfaction was not associated with sexual satisfaction even when considering relationship duration, parenthood, age, educational attainment, or socioeconomic status. Emotional attachment emerged as the sole predictor of relationship satisfaction in RG.
Conclusion: these findings align with previous research suggesting that couples facing sexual challenges adapt their sexual scripts by prioritizing closeness and responsiveness (e.g., affection and physical proximity) to mitigate negative effects on their relationships. Understanding these compensatory mechanisms can offer valuable insights for research on relationship maintenance processes.
Identification of non-invasive PET-CT features for differentiation and prognostication of lung adenocarcinoma and squamous cell carcinoma using radiomics and foundation model
Authors: Vashistha Rajat , Kundu Parveen , Kumar Sandeep , Singh Harmeet , Aoude Lauren G. , Brosda Sandra , Barbour Andrew P. , Vegh Viktor 
Published: February 2025

Abstract

This study demonstrates the potential of non-invasive conventional radiomics and advanced deep learning-based foundation models (DINOv2) for differentiating between ADC and SCC and for identifying prognostic subgroups. Features were extracted from pretreatment PET-CT images of patients diagnosed with ADC and SCC. The performance of features in distinguishing between ADC and SCC was evaluated using statistical tests. Further, patients were clustered based on these features, and Kaplan-Meier survival analysis was performed to assess the prognostic value of the identified clusters. The results demonstrated that both conventional radiomics and DINOv2 features could effectively differentiate between ADC and SCC. First-order radiomic features, including Entropy, Uniformity, and Mean intensity from CT images, and Median and Mean intensity from PET images, showed statistically significant differences between the two cancer types (p < 0.05). Notably, DINOv2 features exhibited consistently higher statistical significance (p < 0.000001) in distinguishing between ADC and SCC, highlighting the superior discriminatory power of deep DINOv2 features. Survival analysis revealed that clustering patients based on both radiomics and DINOv2 features could identify subgroups with distinct survival outcomes. Further validation in larger, multi-center cohorts is warranted to confirm these findings and translate them into clinical practice for improved diagnosis and personalized treatment strategies.
Sustainable Shipping: Modeling Technological Pathways Toward Zero-Emission in Maritime Transport (Part I)
Authors: Caprace Jean-David , Marques Crístofer Hood , Assis Luiz Felipe , Lucchesi Andrea , Pereda Paula 
Published: February 2025

Abstract

Maritime transport accounts for approximately 3% of global greenhouse gas (GHG) emissions, a figure projected to rise by 17% by 2050 without effective mitigation measures. Achieving zero-emission shipping requires a comprehensive strategy that integrates regulatory frameworks, alternative fuels, and energy saving technologies. However, existing studies often fail to provide an integrated analysis of regulatory constraints, economic incentives, and technological feasibility. This study bridges this gap by developing a predictive model to assess the decarbonization pathways for global shipping from 2018 to 2035. A multi-criterion decision analysis (MCDA) framework, coupled with techno-economic modeling, evaluates the cost-effectiveness, technology readiness, and adoption potential of alternative fuels, operational strategies, and market-based measures. The results indicate that technical and operational measures alone can reduce emissions by up to 44%, while market-based measures improve the diversity of sustainable fuel adoption. Biofuels, particularly BISVO and BIFAME, emerge as preferred alternatives due to cost-effectiveness, while green hydrogen, ammonia, and biomethanol remain unviable without additional policy support. A strict carbon levy increases transport costs by 46%, whereas flexible compliance mechanisms limit cost increases to 14–25%. This study provides a robust decision support framework for policy makers and industry stakeholders, demonstrating that well-structured market-based measures can balance emissions reductions with economic feasibility, guiding future regulatory strategies.
Vertical distribution of Methylmercury in the Central Arctic Ocean explained by In Situ Methylation and Demethylation
Authors: Schartup Amina T , Soerensen Anne L. , Calder Ryan S. D. , Heimbürger-Boavida Lars-Eric 
Published: February 2025

Abstract

High levels of neurotoxic monomethylmercury (MMHg) have been reported in the Arctic food web with tissue burdens across various biota estimated to be higher than pre-industrial levels. This enrichment is largely attributed to anthropogenic releases of inorganic mercury, which is assumed to convert partially to methylmercury (MeHg: MMHg + volatile dimethylmercury (DMHg)) in marine systems. While in situ production of MeHg in the Central Arctic Ocean has been hypothesized, direct links between methylation and demethylation rates, and ambient MeHg concentrations have not been established. Here, we report full oceanic water column (3700 m) high-resolution profiles of mercury (Hg) methylation and MeHg demethylation rates. These profiles were obtained during the 2015 German GEOTRACES expedition, using changes in isotopically labeled MeHg and divalent Hg (HgII) during 24-hour incubations. Total Hg, MMHg, DMHg, and ancillary parameters were measured at the same station. We show that both methylation and demethylation rates vary with depth, with methylation rates ranging from 2.0*10-5 to 1.4*10-3 day-1 and demethylation rates varying from 1.0*10-4 to 0.12 day-1. Using measured rates, along with evasion and photodecomposition algorithms, we can simulate MMHg and DMHg distribution with depth. We find that DMHg does not build up in the surface water because of rapid dark demethylation, rather than evasion or photodecomposition, explaining the low surface often DMHg found under sea ice. We show that the peak MeHg is primarily explained by formation of DMHg in the halocline and the location of the peak is controlled by either mixed layer depth and/or the mixing of water with high methylation potential but low MMHg/HgII levels from the Eastern Siberian Sea with Atlantic water carrying substrates for methylation.
Optimizing Stiffener Orientation in Cold-Formed Shear Panel Dampers for Enhanced Ductility and Energy Dissipation
Authors: Elgammal Ahmed , Ali Yasmin 
Published: February 2025

Abstract

Shear panel dampers (SPDs) are critical passive energy dissipation devices used in earthquake-resistant structures. They are designed to yield in shear before other structural members, thereby reducing seismic damage. The hysteretic behavior of SPDs is significantly influenced by the stiffeners attached to their webs, which mitigate web shear buckling. This study investigates SPDs with three distinct stiffener orientations—transverse, longitudinal, and diagonal—to identify the optimal configuration that enhances ductility and energy dissipation. A three-dimensional (3D) finite element model was developed in ANSYS Workbench to analyze SPDs under lateral cyclic loading, incorporating geometric imperfections and material nonlinearity. The model was validated against experimental data, demonstrating its accuracy in predicting hysteretic behavior. Subsequently, 18 SPD specimens fabricated from cold-formed steel and stainless steel were numerically analyzed to evaluate their hysteretic performance. Results revealed that transversely stiffened shear panel dampers (TSPDs) and longitudinally stiffened shear panel dampers (LSPDs) exhibited more stable responses compared to diagonally stiffened shear panel dampers (DSPDs). While DSPDs demonstrated higher shear capacity, they exhibited lower ductility and energy dissipation due to rapid strength deterioration. Among the configurations, LSPDs outperformed TSPDs in terms of buckling resistance, deformation capacity, ductility, and energy dissipation. Based on these findings, preliminary predictive design formulae for LSPDs made of cold-formed stainless steel were derived, providing valuable insights for optimizing their design.
Kontribusi Pendekatan Interdisipliner Dalam Pemahaman Hadis: Perspektif Kontekstual Dan Relevansi Zaman
Authors: Alamudin Muhammad , Nurhamdani Ahmad , Alfi Mahfudz , Amrulloh Amrulloh , Umam Fajrul 
Published: February 2025

Dunia yang semakin kompleks ini, semakin banyak permasalahan yang tidak dapat diselesaikan dengan pendekatan yang sempit. Begitupun dalam memahami hadis, perlu adanya interaksi antar disiplin ilmu supaya terdapat keseimbangan relevansi antara penafsiran agama dan realitas kehidupan. Dari hal ini, penelitian ini bertujuan untuk mengetahui aneka pendekatan interdisipliner dalam memahami hadis dan kontribusi pendekatan interdisipliner dalam memahami hadis. Penelitian ini menggunakan metode deskriptif analitis dengan cara memaparkan data pendekatan interdisipliner dan menganalisis kontribusnya. Hasil penelitian ini menunjukkan adanya beberapa pendekatan interdisipliner dalam memahami hadis. Peneliti merumuskan dan mencontohkan pendekatan sosiologi, sejarah, kesehatan, geografi, psikologi, linguistik, dan filosofis dapat digunakan untuk memahami hadis. Dan menemukan bahwa memahami hadis dengan pendekatan interdisipliner berkontribusi dalam empat hal; meminimalisir kesalahpahaman, memiliki pemahaman yang mendalam, memberikan wawasan situasi sosial dan budaya hadis itu datang, dan mengkontekstualisasikan hadis sesuai waktu dan zamannya.
Silicate liquid immiscibility in the Chang’e 5 lunar mare magmas: constraints on the petrogenesis of lunar granitic rocks
Authors: Zhang Le , Yang Ya-Nan , Wang Jintuan , Cui Ze-Xian , Wang Cheng-Yuan , He Peng-Li , Zhang Yan-Qiang , Lin Mang , Xu Yi-Gang 
Published: February 2025

Abstract
Silicate liquid immiscibility was a common mechanism during the late-stage evolution of lunar basaltic magmas, which produced co-existing and immiscible Si- and Fe-rich melts. However, the relationship between silicate liquid immiscibility and lunar granitic rocks is debated. In this study, we investigated Si-rich melt inclusions hosted in fayalite fragments from lunar soil returned by the Chang’e 5 mission. These melt inclusions have high SiO2 (76.4 wt.%), Al2O3 (11.1 wt.%), and K2O (5.8 wt.%), and low FeO (2.8 wt.%), TiO2 (0.42 wt.%), and MgO (0.02 wt.%) contents. The texture and chemical composition indicate that these Si-rich melt inclusions formed through late-stage silicate liquid immiscibility of the Chang’e 5 mare basaltic magma. Mass balance considerations show that the unfractionated rare earth element patterns and Eu anomalies of these melt inclusions are similar to those of lunar granitic rocks. Dynamic calculations indicate that the accumulation of Si-rich melt was hindered by the high cooling rate of the Chang’e 5 basaltic magma after eruption. However, in deep-crustal magma chambers, basaltic magma would have cooled slowly and the Si-rich melt generated by late-stage silicate liquid immiscibility would possibly have had enough time to migrate upwards and accumulate to form a granitic melt body of significant size. The results of this study support the possibility that lunar granitic rocks are products of silicate liquid immiscibility.
Fractional domain wall statistics in spin chains with anomalous symmetries
Authors: Garre-Rubio José , Schuch Norbert 
Published: February 2025

We study the statistics of domain wall excitations in quantum spin chains. We focus on systems with finite symmetry groups represented by matrix product unitaries (MPUs), i.e. finite depth quantum circuits. Such symmetries can be anomalous, in which case gapped phases which they support must break the symmetry. The lowest lying excitations of those systems are thus domain wall excitations. We investigate the behavior of these domain walls under exchange, and find that they can exhibit non-trivial exchange statistics. This statistics is completely determined by the anomaly of the symmetry, and we provide a direct relation between the known classification of MPU symmetry actions on ground states and the domain wall statistics. Already for the simplest case of a \mathbb Z_2ℤ2 symmetry, we obtain that the presence of an anomalous MPU symmetry gives rise to domain wall excitations which behave neither as bosons nor as fermions, but rather exhibit fractional statistics. Finally, we show that the exchange statistics of domain walls is a physically accessible quantity, by devising explicit measurement operators through which it can be determined.
Assessing the impacts of sea level rise on salinity intrusion in the Kelani River, Sri Lanka
Authors: Athuraliya V. D. , Neluwala Panduka , Pathirana K. P. P. 
Published: February 2025

ABSTRACT

Salinity intrusion poses a significant threat to water treatment processes, especially in regions near coastal aquifers. This challenge is exacerbated by the ongoing impacts of global climate change. This study employs a three-dimensional numerical model to investigate the variation in the spatial and temporal distribution of salinity in a data-scarce river during the dry season and to predict their performance under sea level rise scenarios for the mid and end of this century, as outlined in the Fifth Assessment Report of the Intergovernmental Panel on Climate Change. The model was validated using measured water levels, discharges, and conductive data. The model findings reveal that, compared to current conditions, the average increase in bottom layer salinity is projected to be 11.8, 4.5, and 13.1% in 2050 and 13.8, 17.4, and 27.5% in 2090 under the environmental scenarios Representative Concentration Pathways (RCP) 2.6, RCP 4.5, and RCP 8.5, respectively. Additionally, the simulated results indicate that a saline front of 1 ppt, which significantly impacts water treatment processes, is expected to intrude further inland by approximately 0.5, 3.5, 8.5, and 11 km for respective sea level rise values of 21, 32, 37, and 48 cm, relative to present conditions.
Enzymatic Enantioselective Transesterification Reactions: A Pathway Through Biobased Alternatives
Authors: de Almeida Laiza A. , Milagre Cintia D. F. , Milagre Humberto M. S. 
Published: February 2025

Abstract:
The field of biocatalysis has blossomed exponentially over the past decades and revolutionized
chemical synthesis, providing greener and sustainable methods for preparing numerous organic molecules at
bench and industrial scales and in high stereoselective mode for the chiral ones. However, despite the tremendous
progress, researchers still have room to contribute significantly to the field, especially in the valorization
of agro-industrial waste to boost the circular (bio)economy. This review summarizes the use of lipases, the most
versatile biocatalyst, in enantioselective transesterification reactions. The emphasis is on biobased materials
involved in lipase-catalyzed enantioselective transesterification, such as agro-industrial waste for lipases production
(isolation source and growth), the use of biobased solvents, renewable acyl donors and biobased materials
for enzyme immobilization. We also discuss the perspectives of how to connect the high demand for more
robust enzymes and the development of cost-effectiveness enantioselective methods, as well as the challenges
to achieving a circular economy.
Effects of Shenmai Injection on the Pharmacokinetics of Dasatinib: An In-Depth In vivo Analysis Utilizing UPLC-MS/MS Technique
Authors: Ma Weina , Li Ling , Li Zhihui , Guo Jungang , Zhu Yifei , Ge Liye , Wang Rong , Lv Lei 
Published: February 2025

Background:
Dasatinib has been widely used in the treatment of a variety of cancers, such as lung
cancer and acute myeloid leukemia. Shenmai injection is a traditional Chinese medicine injection that is often
used in antitumor adjuvant therapy. In recent years, dasatinib combined with Shenmai injection has been increasingly
used to treat tumors clinically. However, the potential risks and benefits of co-administering Shenmai
injection and dasatinib are unclear.

Objective:
The study aimed to investigate the potential influence of Shenmai injection on dasatinib pharmacokinetics.

Methods:
Twelve rats were selected and randomly divided into two groups: dasatinib alone and a combination
of dasatinib and Shenmai injection. To measure the concentration of dasatinib in rat plasma, blood samples
were obtained from the orbital vein. Using ultra-performance liquid chromatography-tandem mass spectrometry,
the concentration of dasatinib was determined to obtain pharmacokinetic parameters.

Results:
Compared to the dasatinib alone administration, the maximum concentration of the dasatinib plus
Shenmai injection administration was decreased (355.9 ± 194.9 vs. 199.2 ± 73.8 ng·mL−1) (P < 0.05). Moreover,
the area under the moment curve (3867.0 ± 2141.9 vs. 6355.3 ± 3311.6 ng·mL−1·h2) and mean residence
time (3.7 ± 1.2 vs. 6.5 ± 3.1 h) showed a statistically significant increase (P < 0.05).

Conclusion:
The study revealed that Shenmai injection might have the capacity to slow down the absorption
rate of dasatinib and could extend the retention period of dasatinib in the body, resulting in stabilized blood
drug concentrations and a reduction in adverse drug reactions.
Adherence to Hypertension Medication in Older People: Empirical Research Quantitative
Authors: Huang Mengyun , Zhu Lijun , Chen Yan , Wang Anshi , Wang Jing , Zhang Wanjun , Wang Yang , Jin Yuelong , Yao Yingshui 
Published: February 2025

Introduction:
This study aimed to investigate the factors influencing medication adherence
in community-dwelling Chinese older adults with hypertension.

Design:
Empirical research–quantitative; Cross-sectional study

Methods:
A cross-sectional survey was conducted from September to December 2021, in which participants
completed a self-administered questionnaire with detailed their demographic information.
The Morisky Medication Adherence Scale-8, the Pittsburgh Sleep Quality Index, and the 10-item
Kessler Psychological Distress Scale were used to assess medication adherence, sleep quality, and
psychological well-being, respectively. Multivariate logistic regression analysis was performed with
medication adherence as the dependent variable to identify factors influencing adherence.

Results:
The study included 867 patients with hypertension, comprising 566 women and 301 men
with a mean age of 70.89 ± 7.50 years. Results indicated that 53.9% of participants exhibited high
medication adherence, while 24.5% and 21.7% demonstrated medium and low adherence levels,
respectively. Multiple logistic regression analysis revealed that individuals in the 50–59 age group
had lower medication adherence compared to those aged 80 years and older (odds ratio [OR]: 0.468,
95% confidence interval [CI]: 0.245,0.894). In addition, participants with a primary school education
or less (OR: 0.152, 95% CI: 0.095,0.245) and those living alone (OR: 0.362, 95% CI: 0.228, 0.575)
exhibited poorer medication adherence. Conversely, living in an urban area was associated with better
adherence (OR: 2.131, 95% CI: 1.402, 3.239, p < 0.001).

Conclusion:
Our study showed that participants' medication adherence was below the desired level.
It was observed that older adults, those with a junior high school education or higher, and those living
in urban areas with their children had better medication adherence. These identified predictors may
help to identify individuals at high risk of poor adherence, enabling the implementation of effective
interventions to reduce the global burden of hypertension.
Advances in Phytosome Technology for Targeted Cancer Therapy
Authors: . Urvashi , Garg Anubhav , . Komal , Gupta Parul , . Sachin , Sharma Shubham , Kumar Shubham , Kaur Rupinder , Kriplani Priyanka 
Published: February 2025

Background:
Nowadays, medicinal herbs and their phytochemicals have emerged as a
great therapeutic option for many disorders. However, poor bioavailability and selectivity might
limit their clinical application. Among all approaches, phyto-phospholipid complexes (named
phytosomes) have appeared to be a great method to overcome the problems. With the new
developments in drug delivery technologies, anticancer drugs ranging from hydrophilic
macromolecules to lipophilic drugs can be administered via phytosomes to treat cancer.

Objective:
In the present review, various drugs targeted by phytosomes to treat varied forms of
cancer, like breast cancer, pancreatic cancer, lung cancer, colon cancer, prostate cancer, etc, are
discussed.

Methods:
In this review, recent literature covering phytosomes to treat various forms of cancer,
patent applications, and clinical trials involving phytosomes employed to cure mainly cancer are
covered.

Results:
Phytosomes have proved their potential to cure cancer. They increase the bioavailability
of the drug by site-specific drug delivery and can reduce the side effects/- toxicity associated with
anticancer drugs and also sustain the release of drugs.

Conclusion:
The potential of phytosomes to carry the drug may unclutter novel ways for
therapeutic intercessions in various tumors.