bluuebunny/crossref_metadata_2025_split huggingface dataset:
Deleted in Colon Cancer Protein Expression in Colorectal Cancer Metastases: A Major Predictor of Survival in Patients With Unresectable Metastatic Disease Receiving Palliative Fluorouracil-Based Chemotherapy
Authors: Aschele Carlo , Debernardis Domizia , Lonardi Sara , Bandelloni Roberto , Casazza Stefania , Monfardini Silvio , Gallo Luigi 
Published: September 2004

Purpose To determine whether deleted in colon cancer (DCC) protein expression in colorectal cancer (CRC) metastases could predict outcome to palliative fluorouracil (FU)-based chemotherapy and to assess whether it is similar to that observed in the corresponding primary tumors. Patients and Methods DCC protein expression was assessed immunohistochemically on archival specimens of CRC metastases from 42 patients homogeneously treated by methotrexate-modulated bolus FU alternated to 6-S-leucovorin–modulated infused FU and was retrospectively correlated with patient characteristics and clinical outcome. In a subset analysis, DCC immunoreactivity was compared between metastatic CRC and the corresponding primary tumors and regional lymph node metastases. Results Positive immunoreactivity for DCC was found in 45% of patients. Eighteen (78%) of 23 patients for whom multiple samples were available displayed a similar pattern of expression in distant metastases and primary tumors. The median survival time was 14.3 months in patients without DCC expression and 21.4 months in patients with DCC-positive tumors (log-rank test, P = .04); the 2-year survival rates were 8.5% and 42.5%, respectively. Response rates to chemotherapy were not significantly different between the two groups. By multivariate analysis, DCC protein expression maintained its prognostic value and showed to be the single best predictor of survival, with a relative risk of 2.16. Conclusion Our results indicate that expression of the DCC protein in CRC metastases is similar to that observed in the corresponding primary tumors and represents a dominant predictor of survival in patients with unresectable, advanced CRC who are undergoing palliative FU-based chemotherapy.
Bone Mineral Density Among Premenopausal Women With Early Breast Cancer in a Randomized Trial of Adjuvant Endocrine Therapy
Authors: Sverrisdóttir Á. , Fornander T. , Jacobsson H. , von Schoultz E. , Rutqvist L.E. 
Published: September 2004

Purpose To examine the effects on bone mineral density of 2 years of treatment with a luteinizing hormone-releasing hormone (LHRH) agonist alone or in combination with tamoxifen or tamoxifen alone in premenopausal breast cancer. Patients and Methods We recruited 89 women from two centers in Stockholm participating in a randomized multicenter trial of three different endocrine approaches in the adjuvant setting (Zoladex in Premenopausal Patients Trial). The women were assigned to receive the LHRH agonist goserelin with or without tamoxifen, tamoxifen alone, or no endocrine therapy. The treatment was given for 2 years. We measured total-body bone density before start of treatment and at 12, 24, and 36 months. Results After 2 years of treatment, there was a significant loss of bone mineral density (mean change, −5%; P < .001) in the women receiving goserelin alone. The combined goserelin and tamoxifen treatment, as well as tamoxifen alone, resulted in a lesser but statistically significant decline in bone mineral density (mean change, −1.4%; P = .02; and −1.5%; P < .001). One year after cessation of treatment, the goserelin group alone showed a partial recovery from bone loss (mean change, 1.5%; P = .02). Conclusion Two years of ovarian ablation from goserelin treatment caused a significant reduction in bone mineral density but there was a partial recovery from the bone loss 1 year after cessation of treatment. The addition of tamoxifen seems to partially counteract the demineralizing effects of goserelin.
Phase II Trial of Bortezomib for Patients With Advanced Renal Cell Carcinoma
Authors: Kondagunta G. Varuni , Drucker Beverly , Schwartz Lawrence , Bacik Jennifer , Marion Stephanie , Russo Paul , Mazumdar Madhu , Motzer Robert J. 
Published: September 2004

Purpose To assess the efficacy and toxicity of bortezomib (Velcade; Milennium Pharmaceuticals Inc, Cambridge, MA; formerly PS-341) in patients with metastatic renal cell carcinoma (RCC). Patients and Methods Thirty-seven patients with metastatic RCC were treated with bortezomib. The first 25 patients enrolled onto the trial were treated with a dose of 1.5 mg/m2. The dose was decreased to 1.3 mg/m2 for the subsequent 12 patients, because more than 50% of the patients treated at the higher dose required dose reductions. Bortezomib was given by intravenous administration on a twice-weekly schedule for 2 weeks followed by 1 week without treatment until progression or unacceptable toxicity occurred. Twenty-three patients (62%) previously had undergone nephrectomy, and 19 patients (51%) had previously been treated with cytokine therapy. Results Of the 37 assessable patients, the best response was a partial response in four patients (11%; 95% CI, 3% to 25%) and stable disease in 14 patients (38%; 95% CI, 23% to 55%). The four patients with partial response experienced response durations of 8, 8+, 15+, and 20+ months. Grade 2 or 3 sensory neuropathy was present in 10 patients (53%) overall. One patient in the 1.5 mg/m2 group had grade 3 sensory neuropathy; no grade 3 sensory neuropathy was seen in the 1.3 mg/m2 group. Conclusion The results of this trial suggest that bortezomib has an antitumor effect in individual patients with metastatic RCC. The small proportion of patients who achieved a partial response does not support routine use in metastatic RCC. Efforts to identify the molecular profile associated with clinical response or combination therapy with interferon alfa or other novel agents, may be considered.
Irinotecan Plus Gemcitabine Results in No Survival Advantage Compared With Gemcitabine Monotherapy in Patients With Locally Advanced or Metastatic Pancreatic Cancer Despite Increased Tumor Response Rate
Authors: Rocha Lima Caio M. , Green Mark R. , Rotche Robert , Miller Wilson H. , Jeffrey G. Mark , Cisar Laura A. , Morganti Adele , Orlando Nicoletta , Gruia Gabriela , Miller Langdon L. 
Published: September 2004

Purpose This phase III, randomized, open-label, multicenter study compared the overall survival associated with irinotecan plus gemcitabine (IRINOGEM) versus gemcitabine monotherapy (GEM) in patients with chemotherapy-naive, locally advanced or metastatic pancreatic cancer. Patients and Methods IRINOGEM patients received starting doses of gemcitabine 1,000 mg/m2 and irinotecan 100 mg/m2 given weekly for 2 weeks every 3-week cycle. GEM patients received gemcitabine 1,000 mg/m2 weekly for 7 of 8 weeks (induction) and then weekly for 3 of 4 weeks. The primary end point of the trial was survival. Secondary end points included tumor response, time to tumor progression (TTP), changes in CA 19-9, and safety. Results In each arm, 180 randomly assigned patients comprised the intent-to-treat population evaluated for efficacy; 173 IRINOGEM and 169 GEM patients were treated. Median survival times were 6.3 months for IRINOGEM (95% CI, 4.7 to 7.5 months) and 6.6 months for GEM (95% CI, 5.2 to 7.8 months; log-rank P = .789). Tumor response rates were 16.1% (95% CI, 11.1% to 22.3%) for IRINOGEM and 4.4% (95% CI, 1.9% to 8.6%) for GEM (χ2 P < .001). Median TTP was 3.5 months for IRINOGEM versus 3.0 months for GEM (log-rank P = .352). However, subset analyses in patients with locally advanced disease suggested a TTP advantage with IRINOGEM versus GEM (median, 7.7 v 3.9 months). CA 19-9 progression was positively correlated with tumor progression. The incidence of grade 3 diarrhea was higher in the IRINOGEM group but grade 3 to 4 hematologic toxicities and quality-of-life outcomes were similar. Conclusion IRINOGEM safely improved the tumor response rate compared with GEM but did not alter overall survival.
Effect of joint conformity on glenoid component fixation in total shoulder arthroplasty
Authors: Oosterom R , Rozing P M , Verdonschot N , Bersee H E N 
Published: September 2004

Results of shoulder replacements are inferior and must be improved. Two of the major problems of total shoulder replacements are loosening of cemented glenoid components and wear of polyethylene inlays of uncemented, metal-backed glenoid components. The aim of this study is to investigate the influence of joint conformity on glenoid-component fixation. Keeled glenoid components, with radii of curvature of 24, 25, or 29 mm, were cemented in bone substitutes, placed in a force-controlled test set-up, articulating against a 24 mm humeral head. They were loaded by a constant joint compression force (725 ± 10 N) and a superior subluxation force (shear force), cyclically varying between 0 and 350 ± 1 N. After 200 000 load cycles, the upper and lower glenoid component rim-displacements were measured by custom-made displacement sensors. Additionally, the shear-out strength has been measured to investigate the residual strength. The glenoid component structures with radii of curvature of 24, 25, and 29 mm showed maximum superior rim-displacements of 0.163 (SD = 0.01), 0.299 (SD = 0.0306), and 0.350 (SD = 0.0197) mm respectively, which is a significant difference (p < 0.05). The maximum shear-out strength of glenoid components with radii of curvature of 24, 25, and 29 mm was 2707 (SD = 452), 2648 (SD = 299), and 2631 (SD = 312) N respectively, which is not a significant difference (p < 0.05). However, the results indicate that a conform articulation shows smaller glenoid rim-displacements, which might be beneficial for long-term component fixation.
Direct Observation of Hydroxyapatite Nucleation from Amorphous Phase in a Stoichiometric Calcium/Phosphate Aqueous Solution
Authors: Kim Sujin , Ryu Hyun-Seung , Shin Hyunho , Jung Hyun Suk , Hong Kug Sun 
Published: September 2004

Abstract
Nucleation of hydroxyapatite (HAP) nanocrystals from amorphous calcium phosphate (ACP) nanoparticles in a stoichiometric calcium/phosphate aqueous solution was directly observed by dark field transmission electron microscopy. This observation is a direct evidence of internal arrangement process for the ACP–HAP conversion, while it is against the view of ACP dissolution/reprecipitation for HAP formation in a stoichiometric calcium/phosphate aqueous solution.
A Single-source Approach to Metastable Ni3S4 Crystallites and Their Optical Properties
Authors: Chen Xiangying , Wang Zhenghua , Wang Xiong , Wan Junxi , Liu Jianwei , Qian Yitai 
Published: September 2004

Abstract
Metastable Ni3S4 with good crystallinity has been firstly synthesized via a single-source approach using nickel diethyldithiocarbamate as precursor under hydrothermal conditions. The optical properties of the as-prepared Ni3S4 are evaluated. It is found that the reaction temperature is of importance to the formation of Ni3S4 crystallites.
Synthesizing Multidentate Ferrocenylphosphines: A Powerful Route to Dissymmetrically Tri-Substituted Ferrocenes. X-ray Structure and 13C NMR of a Diaryl–Alkyl-phosphino Ferrocene
Authors: Hierso Jean-Cyrille , Ivanov Vladimir V , Amardeil Régine , Richard Philippe , Meunier Philippe 
Published: September 2004

Abstract
As a powerful route to multidentate ferrocenylphosphines, the synthetic strategy which consists in successively reacting FeCl2 with the suitably substituted cyclopentadienyllithium salts was carried out. The new mixed diaryl/alkyl triphosphine 1,2-bis(diphenylphosphino)-1′-(diisopropylphosphino)-4-tert-butylferrocene, Fc(P)2tBu(PiPr), was obtained in good yield (70%). A very rare through-space nuclear spin–spin coupling JCP = 5.5 Hz was evidenced from its reported 13C NMR and X-ray molecular structure characterizations.
Double Elimination Protocol for Access to Pyridine-Containing Arylene–Ethynylenes
Authors: Orita Akihiro , Nakano Takehiko , Yokoyama Taisaku , Babu Govindarajulu , Otera Junzo 
Published: September 2004

Abstract
The arylene–ethynylene arrays involving pyridine were constructed successfully by taking advantage of double elimination reaction of β-substituted sulfones (sulfoximines) which are easily accessible from arylmethyl sulfones (sulfoximines) and aromatic aldehydes. This protocol was utilized for synthesis of an enantiopure arylene–ethynylene framework bearing a binaphthyl stereogenic core.
A Novel Au12 Supramolecule Composed of Two-, Three-, and Four-coordinated Au(I) Centers Constructed on the S3 Scaffolding
Authors: Nunokawa Keiko , Sunahara Tetsuya , Onaka Satoru , Okazaki Kazuya , Imai Hiroyuki , Inoue Katsuya , Ozeki Tomoji 
Published: September 2004

Abstract
A novel Au12 supramolecule (12) composed of two-, three-, and four-coordinated Au(I) centers was constructed on the S3 scaffolding (trithiocyanurate, S3C3N33−). 12 can be regarded as a tetramer of the Au3 unit, [AuP(3-CF3–C6H4)3]3(S3C3N3) by losing four P(3-CF3–C6H4)3 ligands upon tetramerization. A congener of the monomer unit [AuP(2-py)(C6H5)2]3(S3C3N3) (2) was also synthesized; X-ray study on 2 revealed in turn a monomer structure.
Characteristics of Pyrimidine Nucleobases through Inter-base Interactions on the Crystals of the Ternary Copper(II) Complexes
Authors: Jitsukawa Koichiro , Mizutani Mamoru , Arii Hidekazu , Kubo Ichiro , Izu Yasuyuki , Ozawa Tomohiro , Masuda Hideki 
Published: September 2004

Abstract
Characteristics of pyrimidine bases are demonstrated on the crystals of the ternary copper(II) complexes consisting of bpy and pyrimidine-amino acid. Hemiprotonated CH+:C pair is important for the formation of intermolecular triple hydrogen bonding interaction, mimicking i-motif of DNA. The electron-donating effect in thymine ring among pyrimidine bases also promotes intermolecular π–π stacking interaction.
Stereoselective Preparation of α-Hydroxycarboxamide by Manganese Complex Catalyzed Hydration of α,β-Unsaturated Carboxamide with Molecular Oxygen and Phenylsilane
Authors: Sato Mitsuo , Gunji Yasuhiko , Ikeno Taketo , Yamada Tohru 
Published: September 2004

Abstract
Aerobic oxidation with the combined use of phenylsilane and a manganese complex catalyst was successfully applied to the α,β-unsaturated carboxamide containing a C2-symmetrical chiral auxiliary to afford the corresponding α-hydroxycarboxamide in good-to-high yield with high stereoselectivity.
Oxidative Desulfurization of Diesel Oil with Hydrogen Peroxide in the Presence of Acid Catalyst in Diesel Oil/Acetic Acid Biphasic System
Authors: Yazu Kazumasa , Makino Mitsunori , Ukegawa Koji 
Published: September 2004

Abstract
Dibenzothiophenes are oxidized effectively with H2O2 in the presence of acid catalysts in a tetradecane/AcOH biphasic system. The oxidation proceeds in the AcOH phase and most of the oxidation products stay there, resulting in the successive removal of the dibenzothiophenes from the tetradecane phase. Using this biphasic oxidation system can effectively reduce the sulfur content in diesel oil.
Solvent-free Imino-Aldol Three-component Couplings on a Conveniently-prepared and Reusable Phosphoric Acid-Silica Gel Support
Authors: Lock Sandra , Miyoshi Norikazu , Wada Makoto 
Published: September 2004

Abstract
A new solvent-free procedure for the synthesis of β-amino carbonyl compounds in generally moderate to excellent yields has been developed. Three-component Mannich-type couplings between aldehydes (aromatic, aliphatic, alicyclic, and heterocyclic), aromatic amines and silyl enol equivalents proceeded smoothly on a conveniently prepared and reusable phosphoric acid-silica gel solid support.
Identification of Reaction Model of Pyrolysis Reaction of HDPE
Authors: Kim Seungdo , Kim Young-Chun , Jang Eun-Suk 
Published: September 2004

Abstract
This paper demonstrates how to derive Arrhenius parameters as well as reaction model of pyrolysis reaction of high density polyethylene (HDPE) from isothermal kinetic data. We introduced a state-of-the-art thermobalance that enables to record a weight decrease with time under pure static condition. As a result of comparing experimental reduced time plots (RTPs) with theoretical ones, the pyrolysis reaction of HDPE accommodates “contracting cylinder” model, allowing its model to be 2(1−α)1/2. The reaction model derive here was used to evaluate each Arrhenius parameters from isothermal and non-isothermal data. A couple of evidences strongly support the properness of the reaction model derived from RTP and the corresponding Arrhenius parameters.
Single-crystal-to-Single-crystal Polymerization of 4,4′-Butadiynedibenzylammonium Disorbate
Authors: Odani Toru , Okada Shuji , Kabuto Chizuko , Kimura Tatsumi , Matsuda Hiro , Matsumoto Akikazu , Nakanishi Hachiro 
Published: September 2004

Abstract
Solid-state polymerization of 4,4′-butadiynedibenzylammonium disorbate was investigated. The quantitative polymer yield of the diene moieties was achieved under UV-, X-ray, and γ-ray irradiation, whereas the conversion of diyne moieties was low. X-ray crystal structure analyses of monomer and polymer crystals show the polymerization proceeded under topochemical polymerization mechanism indeed.
Microwave-assisted Synthesis of Single-crystalline CuO Nanoleaves
Authors: Liang Zhen-Hua , Zhu Ying-Jie 
Published: September 2004

Abstract
Single-crystalline CuO nanoleaves with an average thickness of about 10 nm and with lateral sizes of hundreds of nanometers to several micrometers have been successfully synthesized by microwave-heating of an aqueous solution containing copper salt and sodium hydroxide. CuO nanoleaves were characterized by powder X-ray diffraction (XRD), transmission electron microscopy (TEM), selected area electron diffraction (SAED), and UV–vis absorption spectrum. The band gap of CuO nanoleaves was estimated to be ≈2.13 eV, which shows significant blue-shift compared with that of the bulk.
Iridium-Catalyzed Addition Reactions of Ethynylsilane to Quinolines and Isoquinolines Activated by Acyl Chloride
Authors: Yamazaki Yusuke , Fujita Ken-ichi , Yamaguchi Ryohei 
Published: September 2004

Abstract
Addition reactions of ethynyltrimethylsilane to various quinolines and isoquinolines activated by acyl chloride are catalyzed with a few Ir-complexes to afford 2-trimethylsilylethynyl-1,2-dihydroquinolines and 1-trimethylsilylethynyl-1,2-dihydroisoquinolines in good to high yields.
ZnO Particles Encapsulated in Porous Cu2O Nanoparticle Layer Prepared by UV Light-Induced Photoreduction of Cu(NO3)2·3H2O over ZnO in Methanol Suspension
Authors: Lu Lianhai , Fischer Roland A 
Published: September 2004

Abstract
Nano Cu2O particles with size of about 7 nm were directly coated on the surface of ZnO seeds by UV light-induced photoreduction of Cu(NO3)2·3H2O, forming Cu2O/ZnO nanocomposites with a core-shell structure.
Synthesis and Characterization of Monodisperse ZnS Nanospheres
Authors: Zhang Yue , Peng Qing , Wang Xun , Li Yadong 
Published: September 2004

Abstract
The monodisperse ZnS nanospheres were synthesized by a solvothermal method. The nanospheres were characterized using XRD, TEM, UV–vis, and photoluminescence spectra. The results demonstrate that ZnS nanospheres are highly crystalline. The strong photoluminescence emission at 450 nm (blue) can be observed in the ZnS nanospheres.
A Study on the Electronic Effect of Reactions of π-Allylpalladiums Using 2-Arylsulfonyloxy-3-chloropropenes with Ethyl Malonate and Their Synthetic Utilization
Authors: Gotoh Kohei , Matsuura Yasutaka , Hatanaka Fuminori , Sato Setsuko , Kagabu Shinzoh , Yoshimatsu Mitsuhiro 
Published: September 2004

Abstract
We have studied in detail the electronic effect on the reactions of π-allylpalladium with nucleophiles during the reactions of 2-arylsulfonyloxy-3-chloroprop-1-ene with diethyl malonate. The reaction rates increase increasing with the electron-withdrawing effects. We have also shown some synthetic utilization using these 2-arylsulfonyloxyprop-1-enes.
A Novel One-pot Synthesis of Cyanohydrin Alkyl Ethers from Aldehydes Catalyzed by Iron(III) Chloride
Authors: Iwanami Katsuyuki , Oriyama Takeshi 
Published: September 2004

Abstract
A variety of cyanohydrin alkyl ethers were readily prepared from aldehydes with trimethylsilyl cyanide and alkoxy-trimethylsilane under the influence of a catalytic amount of iron(III) chloride in a convenient one-pot procedure.
Facile Route for the Preparation of Hollow Silica Using Aromatic Desilylation in Phenylsilsesquioxane Particles
Authors: Han Seung Hoon , Si Tae Sung , Koo Sang Man 
Published: September 2004

Abstract
Using aromatic desilylation reaction, monodispersed porous hollow silica particles with spherical shape could be prepared from hollow PPSQ particles via simple treatment with fuming sulfuric acid.
Frontier Electron Density Pattern of Dioxin Congeners
Authors: Mizukami Yoshihiro 
Published: September 2004

Abstract
Electron densities of highest occupied molecular orbitals (HOMO) of 75 congeners of chlorinated dibenzo-p-dioxins and a nonchlorinated dibenzo-p-dioxin were calculated. HOMO electron densities are localized mainly in out of plane π orbitals of the 12 carbons and 2 oxygens. These HOMO densities were used as variables in a multivariate statistical analysis. By principal component analysis, the 76 dioxins were classified according to their character. The most toxic dioxins have large negative values of the third principal component scores.
Pt-implanted Boron-doped Diamond Electrodes for Electrochemical Oxidation of Hydrogen Peroxide
Authors: Ivandini Tribidasari A , Sato Rika , Makide Yoshihiro , Fujishima Akira , Einaga Yasuaki 
Published: September 2004

Abstract
Pt-modified diamond electrodes were fabricated for electroanalytical applications by implantation method with a dose of 5 × 1014 cm−2. The electrochemical behavior has been studied for oxidation of hydrogen peroxide by using cyclic voltammetry in phosphate buffer solution. With very low background current in comparison to that of Pt metal electrode, the electrode exhibited higher signal to background ratio (≈3.8 times) as well as better electrochemical and physical stability.
Microwave-assisted Synthesis of Flower-like ZnO Nanosheet Aggregates in a Room-temperature Ionic Liquid
Authors: Cao Jieming , Wang Jun , Fang Baoqing , Chang Xin , Zheng Mingbo , Wang Haiyan 
Published: September 2004

Abstract
A fast and environment-friendly green microwave-heating route to synthesize flower-like ZnO nanosheet aggregates in a room-temperature ionic liquid has been reported. SEM images showed the nanosheets with uniform 50 nm in thickness. The PL spectrum of ZnO nanosheet aggregates exhibits a weak ultraviolet emission and a strong green emission at room temperature.
High-Pressure Synthesis and Properties of a Cerium Germanide CeGe3 with the Cubic Cu3Au Type Structure
Authors: Fukuoka Hiroshi , Yamanaka Shoji 
Published: September 2004

Abstract
A new cerium germanide, CeGe3 was prepared by the reaction of a stoichiometric mixture of CeGe2 and Ge under a pressure of 5 GPa at 1600 °C. It crystallized in a cubic unit cell with a = 4.354 (4) Å, and was isotypic with CeSn3 and CePb3 having the Cu3Au structure. It showed a Curie–Weiss paramagnetic behavior from room temperature to 20 K with a Curie constant C of 0.0495 emu mol−1·K. The effective magnetic moment of 0.63 μB, which was much smaller than the theoretical values of 2.54 μB for Ce3+ (4f1) ions, was observed. This compound showed a metallic behavior with the resistivity of 130 and 7 μΩ·cm at room temperature and 2 K, respectively.