bluuebunny/crossref_metadata_2025_split huggingface dataset:
Prospective healthcare-associated links in transmission of nontuberculous mycobacteria among people with cystic fibrosis (pHALT NTM) study: Rationale and study design
Authors: Gross Jane E. , Caceres Silvia , Poch Katie , Epperson L. Elaine , Hasan Nabeeh A. , Jia Fan , Calado Nogueira de Moura Vinicius , Strand Matthew , Lipner Ettie M. , Honda Jennifer R. , Strong Michael , Davidson Rebecca M. , Daley Charles L. , Nick Jerry A. 
Published: December 2023

Background
Healthcare-associated acquisition and transmission of nontuberculous mycobacteria (NTM) among people with cystic fibrosis (pwCF) has been described, and remains a concern for both patients and providers. This report describes the design of a prospective observational study utilizing the standardized epidemiologic investigation toolkit for healthcare-associated links in transmission of NTM among pwCF.

Methods
This is a parallel multi-site study of pwCF who have infections with respiratory NTM isolates and receive healthcare within a common CF Care Center. Participants have a history of one or more NTM positive airway cultures and have been identified as having NTM infections suggestive of a possible outbreak within a single Center, based on NTM isolate genomic analysis. Participants are enrolled in the study over a 3-year period. Primary endpoints are identification of shared healthcare-associated source(s) among pwCF in a Center, identification of healthcare environmental dust and water biofilm NTM isolates that are genetically highly-related to respiratory isolates, and identification of common home of residence watersheds among pwCF infected with clustered isolates. Secondary endpoints include characterization of healthcare-associated transmission and/or acquisition modes and settings as well as description of incidence and prevalence of healthcare-associated environmental NTM species/subspecies by geographical region.

Discussion
We hypothesize that genetically highly-related isolates of NTM among pwCF cared for at the same Center may arise from healthcare sources including patient-to-patient transmission and/or acquisition from health-care environmental dust and/or water biofilms. This study design utilizes a published, standardized, evidence-based epidemiologic toolkit to facilitate confidential, independent healthcare-associated NTM outbreak investigations within CF Care Centers. This study will facilitate real-time, rapid detection and mitigation of healthcare-associated NTM outbreaks to reduce NTM risk, inform infection prevention and control guidelines, and characterize the prevalence and origin of NTM outbreaks from healthcare-associated patient-to-patient transmission and/or environmental acquisition. This study will systematically characterize human disease causing NTM isolates from serial collection of healthcare environmental dust and water biofilms and define the most common healthcare environmental sources harboring NTM biofilms.

Trial registration
ClinicalTrials.gov NCT05686837.
Association between waist circumference and female infertility in the United States
Authors: Ke Jierong , Feng Yuntian , Chen Zhiyun 
Published: December 2023

Background
Obesity has significant implications for fertility and reproductive health. However, evidences linking abdominal obesity to female infertility were limited and inconclusive. Our objective was to figure out the potential relationship between waist circumference (WC) and infertility among women of childbearing age in the United States using data from the National Health and Nutrition Examination Survey (NHANES).

Methods
Our cross-sectional study included 3239 female participants aged 18–45 years. To explore the independent relationship between WC and female infertility, the weighted multivariable logistic regression and smoothed curve fitting were performed. Interaction and subgroup analyzes were then conducted for secondary analysis.

Results
WC was positively associated with female infertility independent of BMI after adjusting for BMI and other potential confounders. In fully adjusted model, for every 1cm increase in waist circumference, the risk of infertility increased by 3% (OR = 1.03, 95% CI: 1.01–1.06). When WC was divided into five equal groups, women in the highest quintile had 2.64 times risk of infertility than that in the lowest quintile (OR = 2.64, 95% CI: 1.31–5.30). Smooth curve fitting revealed a non-linear but positively dose-dependent relationship between WC and female infertility. Furthermore, we found an inverted U-shaped relationship (turning point: 113.5 cm) between WC and female infertility in participants who had moderate recreational activities and a J-shaped relationship (turning point: 103 cm) between WC and female infertility in participants who had deficient recreational activities.

Conclusions
Waist circumference is a positive predictor of female infertility, independent of BMI. Moderate recreational activities can lower the risk of female infertility associated with abdominal obesity.
Evaluation and chemical characterization of bioactive secondary metabolites from endophytic fungi associated with the ethnomedicinal plantBergenia ciliata
Authors: Prasai Jiwan Raj , Sureshkumar Senthuran , Ahmad Waseem , Ashraf Mohammad , Gopi Chinnadurai , Rajapriya Pandy , Aloufi Abeer S. , Natarajan Nandakumar , Pandi Mohan 
Published: December 2023

AbstractThe objective of this work was to assess the bioactive potential of endophytic fungi,Colletotrichum brevisporum(JPSK3),Pestalotiopsis microspora(JPSK19), andGuignardia mangiferae(JPSK25), fromBergenia ciliata. The antibacterial effects were determined by the well diffusion technique against human pathogens (Staphylococcus aureus,Escherichia coli,Bacillus cereus, andSalmonella typhi) and they showed good activities. In the antioxidant assay, the fungal extractP. microsporashows higher free radical scavenging effects in 2,2-diphenyl-1-picrylhydrazyl (82.48%), hydrogen peroxide (84.91%), superoxide (78.85%), and reducing power absorbance of 0.125 at a dosage of 125 g/mL than other two fungi. The fungal extract was also subjected to phenol and flavonoid quantifications. The fungusP. microsporashows the highest phenol (89.56 0.03 mg of GAE/g of extract) and flavonoid (51.52 0.69 mg of quercetin equivalents/g of extract), respectively. The chemical composition of abundant biologically active compounds was determined by gas chromatography-mass spectrophotometry (GC-MS). Furthermore, it was confirmed through spectral and analytical analysis (thin layer chromatography, ultraviolet, Fourier transform infrared spectroscopy, high-performance liquid chromatography, GC-MS, and nuclear magnetic spectroscopy). InP. microspora, the compound phenol,p-tert-butyl (C10H14O), was confirmed for the first time. This fungal compound could be a potential alternative medicine in the future. This is the first work on endophytic fungal studies of ethnomedicinal plantBergenia ciliata.
On the equation f

n
+ (f″)m ≡ 1
Authors: Dang Guoqiang 
Published: December 2023

Abstract
Let

n

n

and

m

m

be two positive integers, and the second-order Fermat-type functional equation

f

n

+

(

f

″

)

m

≡
1

{f}^{n}+{({f}^{^{\prime\prime} })}^{m}\equiv 1

does not have a nonconstant meromorphic solution in the complex plane, except

(

n
,
m

)

∈

{

(

1
,
1

)

,

(

1
,
2

)

,

(

1
,
3

)

,

(

2
,
1

)

,

(

3
,
1

)

}

\left(n,m)\in \left\{\left(1,1),\left(1,2),\left(1,3),\left(2,1),\left(3,1)\right\}

. The research gives a ready-to-use scheme to study certain Fermat-type functional differential equations in the complex plane by using the Nevanlinna theory, the complex method, and the Weierstrass factorization theorem.
Environmentally friendly reduction of graphene oxide using the plant extract of novel Chromolaena odorata and evaluation of adsorption capacity on methylene blue dye
Authors: Edayillam Parvathi , Nidooli Dilraj , Ganesh Arjun , Chalil Veettil Akshaya , Nangarath Kannoth Deepak 
Published: December 2023

Abstract

Chromolaena odorata is an extremely allelopathic and commonly available herb that conquers neighbouring vegetation, and research is being conducted to utilize it for a wide diversity of applications. In the current study, methylene blue dye (MB) is decomposed by exploring the suitability of novel C. odorata for achieving reduced graphene oxide (RGO) through a simplistic green synthesis method. C. odorata assisted RGO is characterized using X-ray diffraction study, scanning electron microscopy, Raman spectroscopy, UV–visible spectrophotometry, photoluminescence spectroscopy and Fourier transform infrared spectroscopy. These characterizations indicate that the synthesized RGO has a UV–visible absorbance peak at 270 nm, an X-ray diffraction reflection peak at 2θ = 2.12°, and a Raman spectrum having an I

D
/I

G
ratio of nearly 0.98. Moreover, the RGO sample exhibits excellent MB dye scavenging efficiency having an adsorption amount of 300 mg/g. The adsorption kinetics is also investigated which established that adsorption fits very well with pseudo-second-order kinetics. Furthermore, the thermodynamics behaviour of the RGO sample has been carried out and demonstrated that adsorption is endothermic and spontaneous. The present study offers appropriate visions for the eco-friendly reduction of graphene oxide by C. odorata and utilizing it for the remediation of organic dye.
Factors associated with change in moderate or severe symptoms of anxiety and depression in community-living adults and older adults during the COVID-19 pandemic
Authors: Vasiliadis Helen-Maria , Spagnolo Jessica , Bartram Mary , Fleury Marie-Josée , Gouin Jean-Philippe , Grenier Sébastien , Roberge Pasquale , Shen-Tu Grace , Vena Jennifer E. , Lamoureux-Lamarche Catherine , Wang JianLi 
Published: December 2023

Abstract
Objectives
Few are the longitudinal studies on the changes in moderate or severe symptoms of anxiety or depression (MSS-ANXDEP) from before to during the COVID-19 pandemic in Canada. The aim was to study the change in MSS-ANXDEP and associated sociodemographic, economic, psychosocial, health behaviour and lifestyle, and clinical factors.

Methods
The current sample includes 59,997 adults aged ≥ 35 years participating in the 2018 and 2020 health surveys of the 5 established cohorts of the Canadian Partnership for Tomorrow’s Health (CanPath). MSS-ANXDEP was based on a cutoff score ≥ 10 on the 7-item Generalized Anxiety Disorder Scale and Patient Health Questionnaire (PHQ-8). Change in MSS-ANXDEP was categorized as follows: no MSS-ANXDEP, remitted, incident, and persistent. Multinomial regressions were used to study MSS-ANXDEP as a function of sociodemographic, economic, psychosocial, health behaviours and lifestyle, and clinical factors.

Results
Sociodemographic and economic (i.e. age, gender, cohort, race/ethnicity, lower income, decreased in income, work status, being an essential worker), lifestyle and health behaviours (i.e. smoking, cannabis and alcohol use, drinking more alcohol), psychosocial (i.e. provide help to others, information and instrumental support, and change in relationships with friends, family, and partner) and clinical factors (i.e. lifetime mental disorder and multimorbidity) were associated with remitted, incident, and persistent MSS-ANXDEP.

Conclusion
Health and socio-economic factors were associated with changes in symptoms of anxiety and depression during the pandemic, further increasing inequities in mental health needs. Public health campaigns on the importance of healthy behaviours should continue and health policies should reduce economic and social barriers to integrated substance use and mental health care.
Analisis Makna Idiomatis Bahasa Melayu Batu Bara Pada Percakapan Masyarakat Desa Benteng
Authors: Dewi Rahma , Nisa Khairun 
Published: December 2023

Abstrak: Penelitian ini bertujuan untuk mengetahui makna idiomatis bahasa Melayu Batu Bara pada percakapan Masyarakat Desa Benteng Kecamatan Talawi Kabupaten Batu Bara. Metode yang digunakan dalam penelitian ini adalah metode kualitatif yang bersifat deskriptif (penggambaran). Pengumpulan data yang dilakukan menggunakan teknik observasi, teknik wawancara, teknik rekam catat, dan teknik dokumentasi. Idiom adalah perkataan atau kelompok kata yang khususnya untuk menyatakan suatu maksud dengan arti kiasan. Pada saat ini kurangnya pengetahuan generasi sekarang dan kurangnya keinginan untuk melestarikan bahasa daerah Suku Melayu di Kabupaten Batu Bara, mengenai makna idiomatis dalam sebuah percakapan dapat menyebabkan terjadinya sebuah kebodohan sepihak, yang mana para generasi sekarang tidak mengetahui makna dari sebuah idiom yang diungkapkan oleh para orang tua. Makna idiomatis yang terdapat dalam percakapan Masyarakat Desa Benteng, mengandung banyak makna idiomatis Bahasa Melayu Batu Bara Kecamatan Talawi Kabupaten Batu Bara.Kata Kunci: bahasa Melayu; makna idiomatis; percakpan masyarakat Abstract: This study aims to determine the idiomatic meaning of Batu Bara Malay Language in the conversation of the Benteng Village Community, Talawi District, Batu Bara Regency. The method used in this research is a descriptive qualitative method (depiction). Data collection was carried out using observation techniques, interview techniques, note recording techniques, and documentation techniques. Idioms are words or groups of words specifically to express a meaning with a figurative meaning. At this time, the lack of knowledge of the current generation and the lack of desire to preserve the local language of the Malay Tribe in Batu Bara Regency, regarding the idiomatic meaning in a conversation can lead to a one-sided ignorance, where the current generation does not know the meaning of an idiom expressed by people. old. The idiomatic meaning contained in the conversation of the Benteng Village Community, contains many idiomatic meanings in Batu Bara Malay Language, Talawi District, Batu Bara Regency.Keywords: Malay language; idiomatic meaning; community conversation
Perubahan, Pergeseran, dan Pemertahanan Bahasa Sunda di Lingkungan Universitas Pendidikan Indonesia
Authors: Robiah Dini Fitriani Noor , Hernawan Hernawan 
Published: December 2023

Abstrak: Penelitian ini dilatar belakangi oleh fenomena perubahan dan pergeseran berbahasa, yang tadinya menggunakan bahasa Daerah beralih ke bahasa Indonesia. Peristiwa ini sering ditemui di kalangan masyarakat khususnya mahasiswa. Subjek penelitian ini adalah mahasiswa UPI yang lahir di Jawa Barat. Penelitian ini bertujuan untuk mengetahui pola perubahan bahasa Sunda pada mahasiswa UPI ketika berinteraksi, pergeseran pemakaian bahasa Sunda pada mahasiswa UPI, dan langkah yang tepat untuk mempertahankan bahasa Daerah di kalangan mahasiswa UPI. Metode yang digunakan dalam penelitian ini adalah metode deskriptif dengan pendekatan kualitatif. Teknik yang digunakan adalah teknik pengumpulan data melalui penyebaran kuisioner. Hasil dari penelitian ini menunjukan perubahan dan pergeseran bahasa Sunda di kalangan mahasiswa UPI. Dengan persentase 32% memakai bahasa Sunda, 68% sisanya memakai bahasa Indonesia yang dicampur bahasa Sunda. Sehingga didapat upaya-upaya untuk mempertahankan bahasa Sunda dikalangan Mahasiswa UPI. Kata Kunci: perubahan bahasa; pergeseran bahasa; pemertahanan bahasa. Abstract: This research is motivated by the phenomenon of language change and shifting, which had used local languages to switch to Indonesian. This event is often found in the community, especially students. The subjects of this study were UPI students who were born in West Java. This study aims to determine patterns of Sundanese language change in UPI students when interacting, shifting the use of Sundanese in UPI students, and appropriate steps to maintain regional languages among UPI students. The method used in this research is descriptive method with a qualitative approach. The technique used is the technique of collecting data through questionnaires. The results of this study indicate changes and shifts in Sundanese among UPI students. With a percentage of 32% using Sundanese, the remaining 68% using Indonesian mixed with Sundanese. In order to obtain efforts to maintain Sundanese among UPI students.Keywords: change of language; shift of language; retention of language.
Sikap Berbahasa Sunda Mojang Jajaka Kabupaten Bandung Sebagai Ikon 'Urang Sunda'
Authors: Anggraeni Shinta 
Published: December 2023

Abstrak: Penelitian ini dilatarbelakangi oleh pentingnya kemampuan berbahasa Sunda para Mojang Jajaka yang merupakan duta budaya dan pariwisata sebagai ikon 'urang sunda'. Penelitian ini bertujuan untuk mengetahui sikap berbahasa sunda para Mojang Jajaka Kabupaten Bandung di lingkungan keluarga dan pendidikan. Metode yang digunakan dalam penelitian ini adalah metode deskriptif pendekatan kualitatif, dengan teknik observasi dan angket. Instrumen penelitian ini adalah pedoman angket. Penelitian ini mendéskripsikan sikap berbahasa Sunda Mojang Jajaka Kabupaten Bandung di lingkungan keluarga dan pendidikan di Kabupaten Bandung berdasarkan ciri-ciri sikap berbahasa yaitu kesetiaan berbahasa, kebanggaan berbahasa, dan kesadaran adanya norma berbahasa. Hasil penelitian menunjukkan sikap positif, meskipun dalam fenomena yang terjadi penggunaan bahasa sunda berdasarkan kesadaran adanya norma berbahasa masih belum optimal. Hal ini dikarenakan pengetahuan akan Tatakrama Bahasa Sunda yang masih terbilang rendah. Artinya Mojang Jajaka Kabupaten Bandung bangga memiliki bahasa Sunda, tetapi kemampuan yang masih belum optimal menyebabkan Mojang Jajaka Kabupaten Bandung secara umum belum menggunakan bahasa sunda dengan baik.
Hermeneutic Studies of Historical Romanticism of Pajajaran and Siliwangi in Mamaos Cianjuran
Authors: Zainhani Fadila Rahma 
Published: December 2023

This study uses romantic hermeneutic studies to determine the historical value contained in Mamaos Cianjuran. Mamos Cianjuran about Pajajaran and Siliwangi is a literary work that contains high artistic and cultural value. By using the theory of Hermenautics, the essence of writing the work can be obtained. The problems discussed in this study are studied through six methods, 1) place literary works as objects under study and position them as facts of ontology, 2) objectivize their structure, by analyzing the structural work of literature. 3) symbolization. 4) interpretation of symbols, associated with the process of creativity of literati in producing his work. 5) associating symbols with other disciplines to complement the interpretation. 6) the discovery of meaning or message that exists in the literary work. Based on the results of the study, Mamaos Cianjuran contains the author's fantasy about the heyday of Pajajaran and Siliwangi
Clinical characteristics and laboratory profile of symptomatic COVID-19 patients from a tertiary Bangalore rural hospital: the lessons learnt
Authors: Rameshkumar Bharath Raj , Kumar Manoj , Shetty Bipin , Kannan Kanakaraj , Rameshkumar Karuna 
Published: December 2023

Background: Aim of study was to analyse clinical and laboratory features and outcome of COVID-19 patients admitted in second wave of pandemic (April1 to May 31, 2021) (SW) and compare with covid 19 patients in third wave (TW).
Methods: COVID-19 positivity were confirmed in both SW and TW. Demographic features, symptoms and duration were recorded. X ray chest was done at the time of admission and for monitoring. Complete blood count, C reactive protein, renal function tests, liver function tests, LDH and D dimer levels were done. The positive patients were categorized as mild, moderate and severe based on the clinical, imaging and laboratory features.
Results: Among 297 patients screened, 171 patients were diagnosed as positive (57.5%). 107 patients were admitted (62.5%). (M:F ratio - 1.74:1). The most common symptoms for hospitalization were fever, cough and shortness of breath. Though 38 patients had neutrophilia, only 16 of them presented with high NLR ratio. Consolidation on chest X-ray was present in all patients but the degree varied. 38 patients required ICU admission and oxygen support. 18 patients succumbed to disease. Among 140 patients (TW) (December 1 to January 31 2022, 69 (43.1%) were positive. Only 12 patients required hospitalisation. The only symptom was high fever. The NLR ratio ranged from 1-6 and never went beyond 6. All patients were discharged after 2-3 days.
Conclusions: The demographic features, co morbidities, presenting symptom of fever and X ray findings were similar in both waves. But the NLR ratio was never beyond 6 in TW. This was probably due to early reporting and vaccination status of the population and less virulent strain of the virus in TW. The present study confirmed that raised NLR and low levels of oxygen saturation at the time of admission are important predictors of disease severity.
Antibacterial Activity of 1-Dodecylpyridinium Tetrafluoroborate and Its Inclusion Complex With Sulfobutyl Ether-β-Cyclodextrin Against MDR Acinetobacter baumannii Strains
Authors: Rogalsky Sergiy , Hodyna Diana , Semenyuta Ivan , Frasinyuk Mykhaylo , Tarasyuk Oksana , Riabov Sergii , Kobrina Larisa , Tetko Igor , Metelytsia Larysa 
Published: December 2023

Background. The bacterial pathogen Acinetobacter baumannii is one of the most dangerous multi-drug-resistant (MDR) microorganisms, which causes numerous bacterial infections. Nowadays, there is an urgent need for new broad-spectrum antibacterial agents with specific molecular mechanisms of action. Long-chain 1-alkylpyridinium salts are efficient cationic biocides which can inhibit enzymes involved in the biosynthesis of bacterial fatty acids. Incorporating these compounds into inclusion complexes with cyclic oligosaccharide β-cyclodextrin can reduce their relatively high acute toxicity.
Objective. The aim of this research was to develop new anti-A. baumannii agents based on hydrophobic 1-alkylpyridinium salt and its inclusion complex with sulfobutyl ether b-cyclodextrin (SBECD).
Methods. Hydrophobic cationic biocide 1-dodecylpyridinium tetrafluoroborate (PyrC12-BF4) and its inclusion complex with SBECD have been synthesized. The structure of the SBECD/PyrC12-BF4 complex was characterized by 1H Nuclear Magnetic Resonance spectroscopy, as well as UV spectroscopy. In vitro antibacterial activity of the synthesized compounds was estimated against MDR clinical isolates of A. baumannii using standard disc diffusion method. Acute toxicity studies were performed on Daphnia magna model hydro­biont. Molecular docking was performed using the crystal structure of the A. baumannii 3-oxoacyl-[acyl-carrier-protein] reductase (FabG).
Results. The results of 1H NMR study revealed the formation of an inclusion complex between SBECD and PyrC12-BF4. The cationic biocide demonstrated high activity against four tested antibiotic-resistant strains of A. baumannii, whereas the SBECD/PyrC12-BF4 complex was active against only two bacterial strains. Molecular docking of 1-dodecylpyridinium ligand into the active site of the A. baumannii (FabG) showed complex formation at an allosteric site located between subunits C, D. The acute toxicity (LC50) of PyrC12-BF4 and its inclusion complex was found to be 0.007 and 0.033 ml/g, respectively.
Conclusions. Hydrophobic cationic biocide PyrC12-BF4 has high antibacterial activity against MDR A. baumannii. The inhibition of the active site FabG may be one of the possible mechanisms of anti-A. baumannii activity of the PyrC12-BF4. The SBECD/PyrC12-BF4 inclusion complex showed an almost 5-fold reduction in acute toxicity compared to PyrC12-BF4, while retaining activity against certain tested A. baumannii bacterial strains.