bluuebunny/crossref_metadata_2025_split huggingface dataset:
Biallelic variants in GTPBP3: New patients, phenotypic spectrum, and outcome
Authors: Nardecchia Francesca , Carrozzo Rosalba , Innocenti Alice , Torraco Alessandra , Zaccaria Valerio , Rizza Teresa , Pisani Francesco , Bertini Enrico , Leuzzi Vincenzo 
Published: February 2024

AbstractIntroductionCOXPD23 is a rare mitochondrial disease caused by biallelic pathogenic variants in GTPBP3. We report on two siblings with a mild phenotype.Case reportsThe young boy presented with global developmental delay, ataxic gait and upper limbs tremor, and the older sister with absence seizures and hypertrophic cardiomyopathy. Respiratory chain impairment was confirmed in muscle.DiscussionReviewed cases point toward clustering around two prevalent phenotypes: an early‐onset presentation with severe fatal encephalopathy and a late milder presentation with global developmental delay/ID and cardiopathy, with the latter as, is the main feature. Our patients showed an intermediate phenotype with intrafamilial variability.
Atomic Layer Deposition of Epitaxial Ferroelectric Hf0.5Zr0.5O2 Thin Films
Authors: Cho Jung Woo , Song Myeong Seop , Choi In Hyeok , Go Kyoung‐June , Han Jaewoo , Lee Tae Yoon , An Chihwan , Choi Hyung‐Jin , Sohn Changhee , Park Min Hyuk , Baek Seung‐Hyub , Lee Jong Seok , Choi Si‐Young , Chae Seung Chul 
Published: February 2024

AbstractThe groundbreaking discovery of unconventional ferroelectricity in HfO2 opens exciting prospects for next‐generation memory devices. However, the practical implementation, particularly its epitaxial stabilization and a clearer understanding of its intrinsic ferroelectricity has been a significant challenge. The study arouses the potential importance of atomic layer deposition (ALD) for mass production in modern industries, demonstrating its proficiency in achieving epitaxial growth of ferroelectric Hf0.5Zr0.5O2 (HZO) thin films on Yttria‐stabilized zirconia (YSZ) substrates. Moreover, with distinct ferroelectric switching currents, the work reveals the ferroelectric characteristics of epitaxial HZO thin films deposited through ALD on YSZ‐buffered Si substrates, which aligns well with CMOS technology. Overall, the results pave the way for a scalable synthesis system for ferroelectric HfO2‐based materials, hinting at a bright future for low‐temperature epitaxial nanoelectronics.
Structurally Stable, Low H2O Prussian Blue Analogs toward High Performance Sodium Storage
Authors: Gao Yuting , Wu Xingxing , Wang Li , Zhu Yaofeng , Sun Guoxing , Tang Yuxin , Yan Mi , Jiang Yinzhu 
Published: February 2024

AbstractPrussian blue analogues (PBAs) are recognized as promising cathode materials for sodium‐ion batteries (SIBs) due to their facile synthesis, low‐cost, high capacity, and environmental friendliness. However, high water content (>10 wt%) in the framework and unsatisfactory structural stability of PBAs are still the bottlenecks for industrial applications. Herein, interstitial K‐doping is employed to minimize the interstitial water and enhance the structural stability of Na2‐xFeMn[Fe(CN)6] (FeMnPBA), thereby boosting the sodium storage performance. The 3% K‐doping (K‐FeMnPBA3) demonstrates a much‐reduced water content of 6.9%, accompanied by a notably enhanced capacity of 139.1 mAh g−1 at 100 mA g−1 and a remarkable capacity retention of 77.1% after 700 cycles. Furthermore, the K‐FeMnPBA3/hard carbon (HC) pouch cell achieves a stable cyclability with 82.6% capacity retention after 600 cycles. This research offers valuable insights into low‐water PBAs for practical applications in SIBs.
CVD Synthesis of Twisted Bilayer WS2 with Tunable Second Harmonic Generation
Authors: Xu Manzhang , Ji Hongjia , Zhang Mingwen , Zheng Lu , Li Weiwei , Luo Lei , Chen Mengdi , Liu Zheng , Gan Xuetao , Wang Xuewen , Huang Wei 
Published: February 2024

AbstractThe introduction of rotational freedom by twist angles in twisted bilayer (TB) transition metal dichalcogenides (TMDCs) can tailor the inherent properties of the TMDCs, which provides a promising platform to investigate the exotic physical properties. However, direct synthesis of high‐quality TB‐TMDCs with full twist angles is significantly challenging due to the substantial energy barriers during crystal growth. Here, a modified chemical vapor deposition strategy is proposed to synthesize TB‐WS2 with a wide twist angle range from 0° to 120°. Utilizing a tilted SiO2/Si substrate, a gas flow disturbance is generated in the furnace tube to create a heterogeneous concentration gradient of the metal precursor, which provides an extra driving force for the growth of TB‐WS2. The Raman and photoluminescence results confirm a weak interlayer coupling of the TB‐WS2. High‐quality periodic Moiré patterns are observed in the scanning transmission electron microscopy images. Moreover, owing to the strong correlation between the nonlinear optical response and the twisted crystal structure, tunable second harmonic generation behaviors are realized in the TB‐WS2. This approach opens up a new avenue for the direct growth of high‐crystalline‐quality and pristine TB‐TMDCs and their potential applications in nonlinear optical devices.
Photoredox‐Enabled Manganese‐Catalyzed [2+2+2] Cycloaddition of Alkynes
Authors: Zhou Yi , He Yong‐Qin , Wang Xiao‐Yu , Lu Lin , Zhou Zhao‐Zhao , Song Xian‐Rong , Tian Wan‐Fa , Xiao Qiang 
Published: February 2024

AbstractManganese (Mn) is the third most abundant transition metal on Earth and is known for its exceptional biocompatibility. The development of novel catalytic mode for Mn is of great significance to advancing organic synthesis. In this study, the first manganese (Mn)‐catalyzed [2+2+2] cycloaddition of alkynes is achieved with the aid of visible‐light photoredox catalysis. Photoredox catalysis is proposed to promote the transformation by in situ reduction of high‐valent Mn(II) complex to Mn(0) species, thereby initiating the reaction. Additionally, a photooxidation‐induced reductive ellimination step is also suggested. This system is further distinguished by its notable tolerance towards both terminal and internal alkynes as counterparts of diynes.
Back‐End‐of‐Line Integration of Synaptic Weights using HfO2/ZrO2Nanolaminates
Authors: Bégon‐Lours Laura , Slesazeck Stefan , Falcone Donato Francesco , Havel Viktor , Hamming‐Green Ruben , Fernandez Marina Martinez , Morabito Elisabetta , Mikolajick Thomas , Offrein Bert Jan 
Published: February 2024

AbstractIn artificial neural networks, the “synaptic weights” connecting the neurons are adjusted during the training. Beyond silicon, functionalizing the back‐end‐of‐line (BEOL) of CMOS circuits with novel materials is a key enabler for deploying neural network accelerators. The hardware implementation of the synaptic weights requires linear and reprogrammable resistive elements. In ferroelectric tunnel junctions, the resistance is programmed by controlling the configuration of the ferroelectric domains with electrical pulses. From ferroelectric HfZrO4to HfO2–ZrO2nanolaminates (NL), the crystallization temperature lowers below the upper limit of 400 °C required for CMOS BEOL. The device footprint is reduced, and the maximum‐to‐minimum conductance ratio increases from 7 to 32. Operated with pulses in the ultra‐fast (20 ns) and biological (500 µs) timescales, the synaptic plasticity exhibits several regimes. Dynamic hysteresis mode characterization after up to 1011switching cycles indicates the coexistence of ferroelectric and non‐ferroelectric effects such as defect rearrangement. Temperature‐dependent transport measurements in the Ohmic (linear) regime support these conclusions. Multi‐level resistive switching is achieved in HfO2–ZrO2NL co‐integrated to CMOS in the BEOL. 1T‐1R operation is demonstrated, paving the way for hardware implementation of synaptic weights for in‐memory neuromorphic computing.
A comparison of operator and financial characteristics of U.S. beef cow‐calf producers by race
Authors: Davis Christopher G. , Collins LaPorchia A. , Davis Gailda Pitre 
Published: February 2024

AbstractThis study compares financial characteristics of U.S. beef cow‐calf farms by race and highlights potential challenges faced by minority farms based on the historical context in which they operate. We find that, in 2018, factors related to farm size and inefficiencies in generating returns contributed to racial disparities in the profitability of beef cow‐calf farms. Relative to White cow‐calf farms, on average, African American and Native American farms had less acreage, value of production, and net farm income but a higher share at financial risk due to inefficiencies. More research is needed to understand racial differences in farm financial performance.
De Novo Designed Ru(II) Metallacycle as a Microenvironment‐Adaptive Sonosensitizer and Sonocatalyst for Multidrug‐Resistant Biofilms Eradication
Authors: Xu Yuling , Pang Yida , Luo Lishi , Sharma Amit , Yang Jingfang , Li Chonglu , Liu Shuang , Zhan Jianbo , Sun Yao 
Published: February 2024

AbstractAlbeit sonodynamic therapy (SDT) has achieved encouraging progress in microbial sterilization, the scarcity of guidelines for designing highly effective sonosensitizers and the intricate biofilm microenvironment (BME), substantially hamper the therapeutic efficacy against biofilm infections. To address the bottlenecks, we innovatively design a Ru(II) metallacycle‐based sonosensitizer/sonocatalyst (namedRu‐A3‐TTD) to enhance the potency of sonotherapy by employing molecular engineering strategies tailored to BME. Our approach involves augmentingRu‐A3‐TTD’s production of ultrasonic‐triggered reactive oxygen species (ROS), surpassing the performance of commercial sonosensitizers, through a straightforward but potent π‐expansion approach. Within the BME,Ru‐A3‐TTDsynergistically amplifies sonotherapeutic efficacy via triple‐modulated approaches: (i) effective alleviation of hypoxia, leading to increased ROS generation, (ii) disruption of the antioxidant defense system, which shields ROS from glutathione consumption, and (iii) enhanced biofilm penetration, enabling ROS production in deep sites. Notably,Ru‐A3‐TTDsono‐catalytically oxidizes NADPH, a critical coenzyme involved in antioxidant defenses. Consequently,Ru‐A3‐TTDdemonstrates superior biofilm eradication potency against multidrug‐resistantEscherichia colicompared to conventional clinical antibiotics, both in vitro and in vivo. To our knowledge, this study represents the pioneering instance of a supramolecular sonosensitizer/sonocatalyst. It provides valuable insights into the structure‐activity relationship of sonosensitizers and paves a promising pathway for the treatment of biofilm infections.
Patterns, processes and conservation management consequences of intraspecific diversity, illustrated by fishes from recently glaciated lakes
Authors: Koene J. Peter , Bean Colin W. , Kristjánsson Bjarni K. , Skúlason Skúli , Leblanc Camille A.‐L. , Adams Colin E. 
Published: February 2024

Abstract
Patterns in phenotypic and genotypic diversity within many species are becoming increasingly apparent, although there remain many species for which such patterns have yet to be described adequately.
Fishes from recently glaciated ecosystems are likely to be particularly rich in intraspecific diversity, yet current conservation management strategies are, in many parts of the world, particularly in Europe, conventionally and overwhelmingly focused on species, regardless of competing species concepts, and appropriate policies for managing diversity at a sub‐specific level still have to be developed.
Occasional attempts to protect certain vulnerable ecotypes and proposed alternative units of conservation (e.g. ‘Pragmatic Species’ or ‘Evolutionarily Significant Units’) reinforce the conventional primacy of contemporary expressed patterns of variation.
Intraspecific phenotypic and genotypic patterns are ultimately the result of complex processes of divergence; conservation approaches that focus on the products of evolution largely ignore the processes that generate and maintain those patterns. Policies that acknowledge the continuation of evolution, the derivation of novel diversity over often very short time spans and the role of environment in initiating and perpetuating these processes are poorly integrated into management strategy.
To address possible deficits, where intraspecific diversity is not addressed in management practice, we believe it to be important first to characterize hidden genetic and phenotypic diversity, which may intimate eco‐evolutionary processes, initially among species of high conservation status. A second step should be to use an approach to intraspecific diversity that illuminates the ultimate processes and mechanisms that bring about that diversity, which also concedes the central role of the environment and affords adequate protection to the ecosystems that drive these processes, such as the United Nations Convention on Biological Diversity (CBD) Ecosystems approach.
Diving into archival data: The hidden decline of the giant grouper (Epinephelus lanceolatus) in Queensland, Australia
Authors: Chong‐Montenegro Carolina , Thurstan Ruth H. , Pandolfi John M. 
Published: February 2024

AbstractThe giant grouper (Epinephelus lanceolatus) is the largest reef fish in the Indo‐Pacific (~2.5 m TL, >400 kg), and it is highly susceptible to overfishing. Despite regional protections and documented population declines, the species is listed by IUCN as Data Deficient due to minimal long‐term population data and a paucity of life history information. This study used historical fishing records derived from newspaper articles, fishing magazines, grey literature and naturalists' descriptions to collate life history information and reconstruct giant grouper population trends from 1854 to 1958 in Queensland, Australia. Historical recreational catch trends of four biologically distinct grouper size classes demonstrated that over 92 years, fishing disproportionately affected two size classes: immature (fish below reproductive size) and mature individuals. Changes in the probability of capturing a grouper within a recreational fishery were examined as a proxy of relative abundance. The probability of catching a giant grouper within a popular recreational fishery significantly declined from 81% in 1860 to 2% in 1958. Further analysis based on a non‐probabilistic method of giant grouper sighting records showed fluctuations in the giant grouper population trajectory, from a steady decline during the early 20th century to an increase during WWII (1939–1945) followed by a reduction in the last half of the 20th century. This study highlights the importance of archival sources to uncover population trends of rare species by combining quantitative assessments and biological inferences to determine the timing and occurrence of population declines and recoveries and inform how vulnerable fish species respond to the cumulative effects of fishing over time.
Attitudes and perceptions of Irish health care professionals regarding functional neurological disorder: A national survey
Authors: Vance Roisin , Clarke Sarah , O'Keeffe Fiadhnait , Galligan Toni , Doherty Anne , Flynn Cora , Kelleher Eric , Laffan Aoife , Doherty Colin , Gillan Diane 
Published: February 2024

AbstractBackgroundFunctional neurological disorder (FND) is a common and often disabling condition. Limited access to services for FND poses challenges both for patients and their health care providers. This survey explored the attitudes, experiences, support needs and training needs of health care professionals (HCPs) who provide care to individuals with FND in Ireland.MethodsA broad range of HCPs working with patients with FND in Ireland partook in an anonymous online 12‐item survey. Participants were recruited via professional bodies and snowball convenience sampling utilising social media and email invitation. Descriptive and inferential statistics were employed to analyze data.ResultsA total of 314 HCPs working in Ireland completed the survey. 80% were female and over half worked in their current role for more than 10 years. 75% of the sample encountered three or less individuals with FND per month. Identified service‐related challenges to effective patient care included insufficient clinic time, lack of confidence explaining the diagnosis, and the need for greater access to specialist support. Data revealed persisting negative attitudes toward FND patients among a proportion of respondents. The majority of respondents did not feel they received adequate education on FND, with the exception of neurologists, of whom 65% felt adequately trained. The majority of respondents (85%) also felt that people with FND did not have access to appropriate FND services in Ireland.ConclusionThis study indicates that there is a significant need to improve FND education among HCPs in Ireland, in addition to developing appropriately resourced, integrated, multidisciplinary care pathways for the FND patient group.
Yerba Mate as a Protectant against Lipoproteins Oxidation
Authors: Mayer Mariana Spanamberg , Portella Amanda Felipe , Maçalai Camila , Zambra Andressa Leal , Mori Natacha Cossettin , Kessler Nunes Viviane Cecília , Bortolotto Josiane Woutheres , Azzolin Gabriela Bonfanti , Parisi Mariana Migliorini 
Published: February 2024

AbstractOxidative modification of low‐density lipoproteins (LDL) and high‐density lipoproteins (HDL) are important factors determining cardiovascular risk. This study investigated the antioxidant mechanisms and potential protective effect of a hydroethanolic extract of yerba mate (Ilex paraguaiensis; EHEM) on the in vitro oxidation of LDL and HDL. EHEM was found to possess ferric reducing power, DPPH free radical scavenging capacity, metal chelating activity, and NO radical scavenging activity. In addition, EHEM reduced the lipoperoxidation induced by α,α′‐Azodiisobutyramidine dihydrochloride (AAPH) in HDL and LDL at all tested concentrations. In this study, we demonstrate the antioxidant properties of yerba mate and its phytochemical compounds. These properties may effectively prevent the in vitro oxidation of LDL and HDL molecules, a phenomenon linked to the pathogenesis of atherosclerosis.
Neuromodulation of Acid‐Sensitive Ion Channels (ASICs) and Anti‐Inflammatory Potential by Lichenxanthone in Adult Zebrafish (Danio rerio): Experimental and Docking Studies
Authors: Ribeiro Liberato Hortência , Bezerra Maciel Jéssica , Wlisses Da Silva Antônio , Eduarda Uchoa Bezerra Maria , San De Oliveira Brito Luana , Silva Jacilene , Kuerislene Amâncio Ferreira Maria , Machado Marinho Marcia , Marinho Gabrielle S , Deusdênia Loiola Pessoa Otília , Guedes Maria Izabel F , Goberlânio De Barros Silva Paulo , Ferreira de Castro Gomes Andreia , Silva Alencar De Menezes Jane Eire , Silva Dos Santos Hélcio 
Published: February 2024

AbstractThe xanthone lichenxanthone did not show toxic effects (LC50>1.0 mg/mL). lichenxanthone prevented nociceptive behavior induced by acidic saline, and its analgesic effect was blocked by amiloride, highlighting the involvement of neuromodulation of acid‐sensitive ion channels (ASICs). In the analysis of anti‐inflammatory activity, concentrations of 0.1 and 0.5 mg/mL of lichenxanthone reduced the edema induced by k‐carrageenan 3.5 %, observed from the fourth hour of analysis. This effect was similar to that observed with ibuprofen (positive control). No leukocyte infiltrates were observed in lichenxanthone, suggesting that the compound acts in the acute inflammatory response. The results of the molecular docking study revealed that lichenxanthone exhibited better affinity energy when compared to the ibuprofen control against the two targets evaluated.
Case report: Endovascular treatment of transplant renal artery stenosis in patient with normal color duplex ultrasound of the renal artery
Authors: Jalili Javad , Khosroshahi Hamid Tayebi , Malekshoar Mehran , Dehghan Mahshid , Akhgari Aisan , Ghafouri Asbagh Amirhosein 
Published: February 2024

Key Clinical MessageProper diagnosis and treatment of vascular stenosis which is a possible complication of renal transplant is important in improving patients' quality of life and prognosis.AbstractOne known consequence among recipients of renal transplants is graft renal artery stenosis. Early identification and therapy are crucial to avoid graft malfunction and the serious consequences that might arise due to elevated hypertension in several organs. We report a rare case of transplant renal artery stenosis in a mid‐aged woman who presented with edema, hypertension, and increased creatinine 2 months after kidney transplant. The patient had normal renal arterial resistive index (RI) and perfusion index (PI), and there was only a modest decrease in perfusion on duplex ultrasound. Following the patient's renal stenting treatment, angiographic resolution was observed. After 14 days of regulated blood pressure following renal artery stenting, she was discharged from the hospital with her edema resolved. Considering complications in patients with clinical manifestations such as hypertension resistant to treatment and graft dysfunction, vascular stenosis is a notable issue to consider even in the context of normal renal arterial RI, PI, and duplex ultrasound. Proper diagnosis and treatment are of importance to improve patients' quality of life and prognosis.
Construction of metal endocrown for a short clinical second molar crown
Authors: AlHazzani Saad , AlAnazi Entessar , AlMazam Abdulrhman 
Published: February 2024

Key Clinical MessageThis case highlights where a metal endocrown was used as a novel technique. The metal endocrown showed promising outcomes during the 5‐year follow‐up, utilizing a resin base to preserve tissue and act as a stress breaker. This approach was used to preserve the tooth and avoid extraction or periodontal surgery.
Impacts of Graphene Nanoribbon Production Methods on Oxygen‐Reduction Electrocatalysis in Different Environments
Authors: Cardoso Eduardo S. F. , Fortunato Guilherme V. , Rodrigues Clauber D. , Júnior Fausto E. B , Ledendecker Marc , Lanza Marcos R. V. , Maia Gilberto 
Published: February 2024

AbstractInvited for this issue's Front Cover is the group of Prof. Dr. Gilberto Maia. The cover picture schematically illustrates ways to optimize graphene nanoribbons for use in energy‐related electrocatalytic processes, specifically in the oxygen reduction reaction (ORR). Emphasis is placed on the interplay between edge defects, oxygenated groups inherited from the CNT opening process, and their collective influence on the N‐ and P‐doping process. This modulation affects the ORR performance and H2O2 selectivity for specific conditions. Read the full text of the Research Article at 10.1002/celc.202300505.
Ti3C2Tx MXene/carbon composites for advanced supercapacitors: Synthesis, progress, and perspectives
Authors: Cai Yanqing , Chen Xinggang , Xu Ying , Zhang Yalin , Liu Huijun , Zhang Hongjuan , Tang Jing 
Published: February 2024

AbstractMXenes are a family of two‐dimensional (2D) layered transition metal carbides/nitrides that show promising potential for energy storage applications due to their high‐specific surface areas, excellent electron conductivity, good hydrophilicity, and tunable terminations. Among various types of MXenes, Ti3C2Tx is the most widely studied for use in capacitive energy storage applications, especially in supercapacitors (SCs). However, the stacking and oxidation of MXene sheets inevitably lead to a significant loss of electrochemically active sites. To overcome such challenges, carbon materials are frequently incorporated into MXenes to enhance their electrochemical properties. This review introduces the common strategies used for synthesizing Ti3C2Tx, followed by a comprehensive overview of recent developments in Ti3C2Tx/carbon composites as electrode materials for SCs. Ti3C2Tx/carbon composites are categorized based on the dimensions of carbons, including 0D carbon dots, 1D carbon nanotubes and fibers, 2D graphene, and 3D carbon materials (activated carbon, polymer‐derived carbon, etc.). Finally, this review also provides a perspective on developing novel MXenes/carbon composites as electrodes for application in SCs.