bluuebunny/crossref_metadata_2025_split huggingface dataset:
SiO2 /WO3 /ZnO Based Self-cleaning Coatings for Solar Cells
Authors: Koysuren Ozcan , Dhoska Klodian , Koysuren Hafize Nagehan , Markja Irida , Yaglikci Savas , Tuncel Bilge , Bebi Elena 
Published: December 2023

Abstract
The accumulation of pollution and any kinds of contamination on the glass cover of the solar cell affects the efficiency of the photovoltaic (PV) systems. The contamination on the glass cover can absorb and reflect a certain part of the sunlight irradiation, which can decrease the intensity of the light coming in through the glass cover. With the study, it was planned to develop self-cleaning coatings for the PV systems. It was aimed to prevent or reduce the contamination-induced efficiency loss of the existing PV systems. In the scope of the project, SiO2/WO3 and SiO2/WO3/ZnO composites were coated from their solutions on the glass substrates using a dip-coating technique. WO3 was selected as a photocatalyst semiconductor. Under the UV light irradiation, WO3 could absorb the photons of the UV light, generating the photoinduced charge carriers. The photoexcited charge carriers provide both the photoinduced hydrophilicity on the surface of the coating and the photocatalytic degradation of the organic contaminants accumulated on the surface of the coating, which allows water droplets to spread and flow on the surface of the cover glass to remove the contaminations. However, the recombination rate of the photoexcited charge carriers on the WO3 film was high. In order to suppress the recombination of the photoinduced charge carriers, WO3 was coupled with SiO2 and ZnO. Both of these semiconductors improved the photocatalytic activity of the WO3 film. Although SiO2 has superior features in terms of the light transmission, it was not very effective under UV light as a photocatalyst alone. The widely preferred photocatalyst ZnO was added into the composite film structure to enhance the photocatalytic activity. The self-cleaning mechanism of the film coatings on a solar cell was investigated through the photocatalytic dye removal efficiency on the as-prepared film samples. There was a slight decrease in the light transparency and the solar cell efficiency because of the WO3 content of the composite film. On the other hand, coupling the SiO2/WO3 film with ZnO enhanced the photocatalytic activity, and it suppressed the reduction effect of the WO3 phase on both the light transparency and the solar cell efficiency. The photocatalytic dye removal efficiency was increased to over 90% after 240 min of UVA light irradiation. In addition, the solar cell coated with the SiO2/WO3/ZnO film provided almost the same solar cell efficiency as the uncoated solar cell. The water contact angle measurement also exhibited the photocatalytic degradation of the model contamination on the glass cover of the solar cell under the UVA light irradiation.
Electroactive Composite Biofilms Integrating Kombucha, Chlorella and Synthetic Proteinoid Proto–Brains
Authors: Nikolaidou Anna , Mougkogiannis Panagiotis , Adamatzky Andrew 
Published: December 2023

Abstract
In this study, we present electroactive biofilms made from a combination of Kombucha zoogleal mats andthermal proteinoids. These biofilms have potential applications in unconventional computing and roboticskin. Proteinoids are synthesised by thermally polymerizing amino acids, resulting in the formation ofsynthetic protocells that display electrical signalling similar to neurons. By incorporating proteinoids intoKombucha zoogleal cellulose mats, hydrogel biofilms can be created that have the ability to efficiently transfercharges, perform sensory transduction, and undergo processing. We conducted a study on the memfractanceand memristance behaviours of composite biofilms, showcasing their capacity to carry out unconventionalcomputing operations. The porous nanostructure and electroactivity of the biofilm create a biocompatibleinterface that can be used to record and stimulate neuronal networks. In addition to in vitro neuronal interfaces, these soft electroactive biofilms show potential as components for bioinspired robotics, smart wearables,unconventional computing devices, and adaptive biorobotic systems. Kombucha-proteinoids composite filmsare a highly customizable material that can be synthesised to suit specific needs. These films belong toa unique category of “living” materials, as they have the ability to support cellular systems and improvebioelectronic functionality. This makes them an exciting prospect in various applications. Ongoing effortsare currently being directed towards enhancing the compositional tuning of conductivity, signal processing,and integration within hybrid bioelectronic circuits.
Clinical Application of Oral Contrast-Enhanced Ultrasound in Evaluating Preoperative T Staging of Gastric Cancer by Using AJCC 8th Staging Criteria
Authors: Liang Yu , Jing Wanyi , Song Jun , Wei Qiuxin , Cai Zhiqing , Li Juan , Wu Ping , Ma Yi 
Published: December 2023

Abstract

Objective:
To investigate the clinical application of Oral Contrast-Enhanced Ultrasound (OCEUS) in evaluating preoperative T staging of Gastric Cancer (GC).
Methods:
OCEUS was performed before the operation and standard ultrasound images were retained. The depth of infiltration of GC (T-stage) was evaluated according to the AJCC 8th TNM staging criteria. Finally, with the postoperative pathological staging as the gold standard reference, the sensitivity, specificity, negative predictive value, positive predictive value, and diagnostic value of OCEUS T staging were evaluated.
Results:
The diagnostic accuracy of OCEUS was T1a: 76.6%, T1b: 69.6%, T2:62.7%, T3:60.8%, T4a: 88.0%, T4b: 88.7%, and the total accuracy was 75.5%. The PPV of OCEUS were T1a: 76.6%, T1b: 69.6%, T2:62.7%, T3:60.8%, T4a: 88.0%, T4b: 88.7%. The sensitivity of ultrasonic T staging was higher than 62% except for T1b, which was 40.3%. The specificity of all ultrasonic T staging was higher than 91% except T3, which was 83.5%. The specificity of all ultrasonic T staging was higher than 91%, and the Youden index was higher than 60% except for T1b and T2. In T4b-stage tumors, OCEUS T staging was in good agreement with pathological T staging (kappa value > 0.75), whereas in T1a, T1b, T2, T3, and T4a tumors, it is in moderate agreement with pathological T staging (kappa value 0.40~0.75). The coincidence rate of OCEUS T staging was higher than 84%.
Conclusion:
OCEUS was effective, reliable, and accurate in diagnosing preoperative T staging of GC. Being a non-invasive diagnostic technique, OCEUS is worthy of clinical popularization.
Ultrasound-guided percutaneous transhepatic one-step biliary fistulation combined with rigid choledochoscopy for recurrent hepatolithiasis
Authors: Pan Wu , Lu Yuhang , Li JunJie , Zhang Jia , Chen Shenglin 
Published: December 2023

Abstract
(1) Purpose: Percutaneous transhepatic one-step biliary fistulation (PTOBF) is used to treat choledocholithiasis and biliary stricture. This study aimed to evaluate the safety and efficacy of ultrasound-guided PTOBF combined with rigid choledochoscopy in the treatment of recurrent hepatolithiasis.
(2) Materials and Methods: The clinical data of 37 consecutive patients who underwent PTOBF combined with rigid choledochoscopy for RHL from March 2020 to March 2022 at our hospital were retrospectively analyzed.
(3) Results: A total of 68 percutaneous transhepatic punctures were performed in 37 patients, with a puncture success rate of 85.29% (58/68) and a dilatation success rate of 100.00% (58/58). The mean blood loss of operation was 9.84±18.10mL, the mean operation time was 82.05±31.92min, and the mean length of postoperative hospital stay was 5.59±3.26 days. The initial stone clearance rate was 40.54% (15/37) and the final stone clearance rate was 100% (37/37). The incidence of postoperative complications was 10.81% (4/37), including 2 cases of pleural effusion, 1 case of hemorrhage, and 1 case of cholangitis, which recovered after treatment. During a mean follow-up period of 23 months (range 12 to 36 months), only 1 patient experienced stone recurrence.
(4) Conclusion: Ultrasound-guided PTOBF combined with rigid choledochoscopy is safe, effective, and minimally invasive for the treatment of RHL, and has clinical application value.
Combined analysis of the 12.8 and 15 microns JWST/MIRI eclipse observations of TRAPPIST-1 b
Authors: Ducrot Elsa , Lagage Pierre-Olivier , Min Michiel , Gillon Michael , Bell Taylor , Tremblin Pascal , Greene Thomas , Dyrek Achrène , Waters Rens , Güdel Manuel , Henning Thomas , Vandenbussche Bart , Absil Olivier , Barrado David , Boccaletti Anthony , Coulais Alain , Decin Leen , Edwards Billy , Gastaud René , Bouwman Jeroen , Glasse Alistair , Kendrew Sarah , Olofsson Göran , Patapis Polychronis , Pye John , Rouan Daniel , Whiteford Niall , Argyriou Ioannis , Cossou Christophe , Glauser Adrian , Krause Oliver , Lahuis Fred , Royer Pierre , Scheithauer Silvia , Colina Luis , Dishoeck Ewine van , Östlin Göran , Ray Thomas , Wright Gillian 
Published: December 2023

Abstract

The first JWST/MIRI photometric observations of TRAPPIST-1 b allowed for the detection of the thermal emission of the planet at 15 μm, suggesting that the planet could be a bare rock with a zero albedo and no redistribution of heat. Here we present five new occultations of TRAPPIST-1 b observed with MIRI in an additional photometric band at 12.8 μm. We perform a joint fit of the 10 eclipses and derive a planet-to-star flux ratio of 452 ± 86 ppm and 775 ± 90 ppm at 12.8 μm and 15 μm, respectively. We test a large range of models and find that the data can be well fitted by either an airless planet model with an unweathered (fresh) ultramafic surface, that could be indicative of relatively recent geological processes, or, more surprisingly, by a thick pure CO2 atmosphere with photochemical hazes that create a temperature inversion and results in the CO2 feature being seen in emission. Our results highlight the challenges in accurately determining a planet’s atmospheric or surface nature solely from broadband filter measurements of its emission, but also point towards two very interesting scenarios that will be further investigated with the forthcoming phase curve of TRAPPIST-1 b.
Whether AI+CDK4/6i+HP is suitable treatment for three positive metastatic breast cancer patient with renal insufficiency caused by type 2 diabetes
Authors: Gang Li , Li Hanjie , Ge Peng , Yu Jiao 
Published: December 2023

Abstract

Background: Hormone-receptor positive (HR+)，ERBB2 gene mutation(HER2+)breast cancer is a very common type of breast cancer, but it is relatively rare for metastatic breast cancer (MBC) who are newly treated and have renal insufficiency. In previous studies, no long-term survival reports have been found for such patients. In order to clarify the above issues, we have innovatively developed a plan that focuses on molecular targeted therapy and endocrine therapy.We reported the results of a breast cancer patient with HR+and HER2+concurrent renal insufficiency. Although the patient did not have the opportunity to receive surgical treatment and chemotherapy, the results showed that the aromatase inhibitors(AI)+Cyclin D-cyclin-dependent kinase 4/6 inhibitor(CDK4/6i)+trastuzumab & pertuzumab(HP) treatment was also an effective and feasible approach.
Patient and methods: The patient with HR+ HER2-positive MBC with activating HER2 mutation(s) received AI+CDK4/6i+HP(oral letrozole 2.5 mg/day,oral abemaciclib 150mg twice/day with mandatory loperamide prophylaxis for the first 2 cycles and as needed thereafter , and intravenous trastuzumab 8mg/kg initially then 6 mg/kg every 3 weeks plus pertuzumab 840mg initially then 420mg every 3 weeks ) therapy. Efficacy endpoints included progression-free survival (PFS) (RECIST v1.1). Secondary endpoints are treatment time, exploratory targets are tumor markers, and safety targets are changes of renal function. Plasma was collected during and at end of treatment. Extracted DNA was analyzed by next-generation sequencing.
Results: The duration of response time lasted for approximately 60 weeks. The treatment time was 81weeks.The PFS was 17.6 months. Responses were observed in patient within 6 weeks. Longitudinal ctDNA sequencing revealed acquisition of additional HER2 alterations, and mutations in genes including PIK3CA.Throughout the entire treatment cycle, the patient's renal function remained stable, with no significant fluctuations in creatinine, creatinine clearance rate, serum urea, and serum potassium.
Conclusions: AI+CDK4/6i+HP is a safe and effective treatment for patients with three positive metastatic breast cancer patients with renal insufficiency caused by type 2 diabetes. Throughout the entire treatment process, the patient's renal function remains stable.Further investigation is needed.
Evaluation of solubility and thermodynamic properties of synthetic nickel hydroxide carbonate
Authors: Gogol D. B. , Makasheva A. M. , Sadyrbekov D. T. , Dyussembayeva L. F. , Rozhkovoy I. E. , Ishmiev I. I. , Zemskiy O. I. , Aldabergenova S. K. 
Published: December 2023

Abstract

Knowledge of the values of the thermodynamic functions of natural minerals of transition elements has important applications in the study of the processes of their formation and geochemical migration with groundwater; when developing methods to prevent corrosion of non-ferrous alloys in fresh and sea water; when immobilizing heavy metals in mine drainage and industrial waters, etc. Also, these values are in demand when calculating reactions and developing methods for producing synthetic analogues of minerals, many of which exhibit magnetic, catalytic, photochemical and other properties. A sample of basic nickel carbonate with the theoretical formula Ni3[СO3](OH)4·3H2O was obtained using the hydrothermal synthesis method. The structure of the compound was verified by X-ray diffraction and infrared spectroscopy. Experiments were carried out on sample dissolution in order to measure the solubility constant (solubility product): logKSP = − 45.8 ± 1.8. Based on the data obtained, the thermodynamic parameters of the reaction of dissolution of the compound were determined and the main thermodynamic functions were determined: Gibbs free energy of formation ΔfG°=−1554 ± 6 kJ/mol; enthalpy of formation ΔfH°=−1798 ± 9 kJ/mol; standard entropy S°=260.6 ± 7.8 J/(mol·K).
Understanding the Influencing Factors and Evolving Trend of the Yellow River Water-Sediment Regulation System from a System Perspective
Authors: Cao Zhiwei , Zhang Yuansheng , Chen Huanfa , Li Chaoqun , Luo Yuan 
Published: December 2023

Abstract

Understanding the influencing factors and evolving trend of the Water-Sediment Regulation System (WSRS) is a fundamental scientific concern for safeguarding and managing the Yellow River. Prior research on the WSRS has been limited in its scope, as it has not employed a systematic analysis or considered the entire basin's engineering control system. This study takes a holistic approach, examining the sediment issue in the Yellow River as a dynamic and continuously evolving complex system. By integrating various theories such as system science, information theory, and dissipative structure, this study combines theoretical knowledge with practical sediment engineering control efforts. Research major finding: from 1990 to 2019, the average value of Sediment Regulation Index (SRI) was 55.99 points, the lowest was 50.26 points in 1990, and the highest was 61.48 points in 2019; the result indicate that the WSRS was less active, but the overall trend was oscillatory, and the overall trend moved gradually closer to the critical threshold of dissipative structure.
Bibliometric analysis on trends and future directions of research and development in seed orchards
Authors: Yardibi Fatma , Kang Kyu-Suk , Özbey Alper Ahmet , Bilir Nebi 
Published: December 2023

Abstract

Seed orchard is one of the most important seed sources to produce improved seed crop to future plantation practices, and to transmit the current gene diversity to future generations. Seed orchard is also one of the main sub-divisions in forest science. It has many steps from selection of superior trees to harvesting of seed crop by establishment and management. Trends and future direction of seed orchards are getting importance especially to establish resistance forests against various environmental conditions due to global climate change. This study was carried out to analysis current trends of research in seed orchards for future directions in the orchards. For the purposes, 1018 published papers, hit in database of “Web of Science” by “seed orchard” keyword, between 1980 and 2022 were analyzed bibliometrical based on the most prolific contributors, references, countries and keywords. The average of citations per publication was 13.05 by 48 H-Index of the publication set. The most prolific contributors with the strongest citation burst, centrality and numbers of published papers were from Canada, Sweden South Korea, Finland and Czechia, while Canada (186 articles) USA (140), and Sweden (115) together with China, Brazil and Germany were active countries especially by citations of recent years. “Key words” of the papers were mirrors of the researches. “Matting pattern” “Swedish forestry”, “fertility variation”, “Hymenoscyphus fraxineus”, “threatened pacific sandalwood”, “outbreeding depression”, “climate change”, “management” and “growth” together with others such as “genetic improvement” and “effective size” were active study areas and key words based on results of the analysis. They were also guides in literature search, and inventory and classification of early studies, and predictor for future studies. Results of the study were discussed based on trends and future directions of research and development in seed orchards.
LINC01836 Promotes Colorectal Cancer Progression and Functions as
ceRNA to Target SLC17A9 by Sponging miR-1226-3p
Authors: Xu Zhihua , Yu Yue , Ni Hao , Sun Wei , Kuang Yuting 
Published: December 2023

Background:
Increasing evidence proves that long non-coding RNAs (lncRNAs) play a
key role in the occurrence and development of colorectal cancer. However, the function and
molecular mechanism of LINC01836 in CRC are still unknown.

Methods:
The differentially expressed lncRNAs in colorectal cancer were obtained from the RNA
sequencing data. The effects of LINC01836 on colorectal cancer cells were tested in in vitro
experiments. The mechanism of LINC01836 action was investigated through western blot, RNA
immunoprecipitation assay and luciferase reporter assay. Moreover, the xenograft mouse model
was conducted to examine the effects of LINC01836 in vivo.

Results:
In this study, we showed that LINC01836 was significantly elevated in colorectal cancer
tissues and cells. Elevated LINC01836 expression significantly correlated with larger tumor size,
positive lymph node metastasis, distant metastasis, advanced tumor-node-metastasis (TNM) stage,
and poor prognosis. Furthermore, decreased expression of LINC01836 repressed proliferation,
migration, and invasion in vitro and vivo, and high LINC01836 expression displayed the opposite
effect. Further analysis revealed that LINC01836 could regulate the expression of SLC17A9 by
competing with miR-­‐1226-3p. Furthermore, down-regulation of LINC01836 or increased
expression of miR-­‐1226-3p markedly reversed the effects of SLC17A9 overexpression on
colorectal cancer cells.

Conclusion:
This study showed that LINC01836 regulated the expression of SLC17A9 through
sponge miR-1226-3p by acting as a competitive endogenous RNA (ceRNA), promoted the
progression of colorectal cancer, and suggested a new prognostic biomarker and potential cancer
treatment target for colorectal cancer.
In Silico Tools to Thaw the Complexity of the Data: Revolutionizing Drug Research
in Drug Metabolism, Pharmacokinetics and Toxicity Prediction
Authors: Sree Kommalapati Hema , Pilli Pushpa , Golla Vijaya Madhyanapu , Bhatt Nehal , Samanthula Gananadhamu 
Published: December 2023

Abstract:
In silico tool is the flourishing pathway for Researchers and budding chemists to strain the analytical
data in a snapshot. Traditionally, drug research has heavily relied on labor-intensive experiments, often limited by
time, cost, and ethical constraints. In silico tools have paved the way for more efficient and cost-effective drug
development processes. By employing advanced computational algorithms, these tools can screen large libraries
of compounds, identifying potential toxicities and prioritizing safer drug candidates for further investigation. Integrating
in silico tools into the drug research pipeline has significantly accelerated the drug discovery process,
facilitating early-stage decision-making and reducing the reliance on resource-intensive experimentation. Moreover,
these tools can potentially minimize the need for animal testing, promoting the principles of the 3Rs (reduction,
refinement, and replacement) in animal research. This paper highlights the immense potential of in silico
tools in revolutionizing drug research. By leveraging computational models to predict drug metabolism, pharmacokinetics,
and toxicity. Researchers can make informed decisions and prioritize the most promising drug candidates
for further investigation. The synchronicity of In silico tools in this article on trending topics is insightful
and will play an increasingly integral role in expediting drug development.
Alarming Rise of Primary HIV Drug Resistance in Major Regions of Russia
Authors: Kireev Dmitry , Kirichenko Alina , Lebedev Aleksey , Bobkova Marina 
Published: December 2023

Objective::
The study aimed to compare the prevalence of surveillance HIV drug resistance
mutations (SDRMs) across the main federal districts of Russia.

Methods::
A pooled analysis was conducted to examine data on HIV primary drug resistance (HIV
PrimDR). The analysis was based on published results primarily from Russian regional clinical
and scientific laboratories, covering a span of 20 years.

Results::
The findings indicate that three surveyed regions, namely Central, Far Eastern, and Volga,
exhibit a low level of HIV PrimDR prevalence (not exceeding 5%), and this prevalence does
not show a tendency to increase. In contrast, three major regions, namely Northwestern, Southern,
and Siberian, demonstrate a significant and progressive increase in HIV PrimDR prevalence, with
recent values surpassing 10%.

Conclusion::
Consequently, it was concluded that a change in the HIV treatment strategy in these
regions is imperative, emphasizing the need to expedite the transition to the utilization of secondgeneration
integrase inhibitors.