bluuebunny/crossref_metadata_2025_split huggingface dataset:
Implementation of an Awareness Level Training to Prepare the Workforce for Future Infectious Disease Outbreaks
Authors: Workman Brandon , Fulk Florence , Carreón Tania , Nabors Laura 
Published: January 2024

Abstract

Objective:
The COVID-19 pandemic underscores the need for workforce awareness-level training for infectious disease outbreaks. A training program was created and evaluated to provide strategies for emergency preparedness as well as worker health and safety during a disease outbreak.

Methods:
Participants (N = 292) completed instructor-led synchronous online training modules between January 2022 and February 2023. Training covered 5 areas: vaccine awareness, infectious disease transmission and prevention, pandemic awareness, and inapparent infections, as well as workplace controls to reduce or remove hazards. Participants completed a survey before and after training to assess knowledge change in the five areas. Chi-square analyses assessed how predictors were related to knowledge change.

Results:
Overall, an increase in knowledge was observed between pre- (80.9%) and post-training (92.7%). Participants from small businesses, with less work experience, and in non-health care roles were under-informed. Knowledge of disease transmission and prevention improved for non-health care professions and workers with less experience. All participants gained knowledge in identifying and ranking safeguards to protect workers from injuries and illness at job sites.

Conclusions:
Training improved employee knowledge about safe work practices and pandemic preparedness. Studies should continue to evaluate the effectiveness of preparedness training to prepare the workforce for infectious disease outbreaks and pandemics.
Reducing plastic production: Economic loss or environmental gain?
Authors: Cordier Mateo , Uehara Takuro , Jorgensen Bethany , Baztan Juan 
Published: January 2024

Abstract
We reviewed economic and environmental studies on global plastic pollution and we estimate the global cost of actions toward zero plastic pollution in all countries by 2040 to be US$ 18.3–158.4 trillion (cost of a 47% reduction of plastic production included). If no actions are undertaken, we estimate the cost of damages caused by plastic pollution from 2016 to 2040 to be US$ 13.7–281.8 trillion. These ranges suggest it is possible that the costs of inaction are significantly higher than those of action. Plastic product sales will also generate a global benefit in the form of incomes (salaries, dividends etc.) estimated to be US$ 38.0 trillion over 2016–2040 in the case of inaction, and US$ 32.7–33.1 trillion in case of action. Calculating benefit minus costs provides the net benefits: US$ −120.4 to 19.7 trillion in case of action and US$ −243.8 to 24.3 trillion in case of inaction. Net benefit ranges suggest action and inaction will both be beneficial when considering the high estimates. However, the low estimates show net benefits might be negative, which suggests inaction might generate a net cost for society that will be twice the cost of action. Our estimates are preliminary (several cost and benefit data are lacking).
Current practices of Portuguese speech-language pathologists with preschool-age children with pragmatic impairment: A cross-sectional survey
Authors: PEREIRA Tatiana , RAMALHO Ana Margarida , LOUSADA Marisa 
Published: January 2024

AbstractThis study aims to investigate the practice patterns used by Portuguese speech-language pathologists (SLPs) with preschool-age children with pragmatic impairment and to identify the actual need(s) perceived by SLPs in this field. A total of 351 SLPs responded. The results reveal that 81.5 per cent of the respondents (n=286) reported working or had previously worked with preschool-age children with pragmatic impairment arising from autism spectrum disorder, developmental language disorder, or both. Considering the clinical practice, similarities and differences were found, many of which are due not to the inherent characteristics of each disorder but to the scarcity of research in clinical pragmatics. These results are also reflected in the needs perceived by SLPs and the degree of confidence with which they work with these children. Implications for clinical practice and directions for future research are discussed.
Dynamics of the Barrier Layer Dipole in the Equatorial Indian Ocean
Authors: Li Junde , Han Di , Liao Guanghong , Zhang Tao , Ding Ruibin , Song Xunshu 
Published: January 2024

AbstractThe barrier layer (BL) significantly impacts the upper ocean circulation and thermodynamic structure by inhibiting the heat and momentum exchange between the mixed layer (ML) and the subsurface layer. There exist sea surface temperature and salinity dipole modes in the tropical Indian Ocean, however, a BL dipole mode has not yet been identified. Using the latest observations and ocean reanalysis, here we show a robust BL dipole mode in the central and eastern equatorial Indian Ocean, which is highly correlated with the Indian Ocean Dipole (IOD) events. Composite analysis shows that the BL thickness anomalies peak in autumn and are much larger during positive IOD events than during negative IOD events. We show that a positive BL dipole phase is characterized by positive BL thickness anomalies in the central equatorial Indian Ocean and negative BL thickness anomalies in the eastern equatorial Indian Ocean, and vice versa for a negative BL dipole phase. During positive IOD events, negative surface salinity anomalies slightly affect the ML depth along the equatorial Indian Ocean. Positive subsurface temperature anomalies deepen the isothermal layer (IL) in the central equatorial Indian Ocean and strong negative subsurface temperature anomalies significantly lift the IL in the eastern equatorial Indian Ocean, controlling the BL thickness anomalies and forming a positive BL dipole pattern. This operates in an opposite direction during negative IOD events. Our study shows a close relationship between the BL dipole and the IOD and has far‐reaching implications for better understanding and predicting the IOD events.
A Substorm‐Dependent Negative Limit of Non‐Eclipse Surface Charging of a Chinese Geosynchronous Satellite
Authors: Fu Zhiyi , Su Zhenpeng , Miao Bin , Wu Zhiyong , Li Yiren , Liu Kai , Shan Xu , Wang Yuming 
Published: January 2024

AbstractSurface charging is one of the most common causes of spacecraft anomalies. When and to what potential the spacecraft is charged are two important questions in space weather. Here, for a Chinese geosynchronous navigation satellite, we infer the extreme negative surface charging potentials from the ion differential fluxes measured by a low‐energy ion spectrometer. Without the solar eclipse effect away from the midnight, the charging potentials are found to have a negative limit which is determined by the maximum SuperMAG electrojet index in the preceding 2 hr. Such an empirical relation can be reasonably explained by the dependence of 1–50 keV electron fluxes on substorm strength. Similar relations may also exist for other inner magnetospheric spacecraft in the non‐eclipse region, which would be useful for spacecraft engineering and space weather alerts.
Observation of transition from superfluorescence to polariton condensation in CsPbBr3 quantum dots film
Authors: Mao Danqun , Chen Linqi , Sun Zheng , Zhang Min , Shi Zhe-Yu , Hu Yongsheng , Zhang Long , Wu Jian , Dong Hongxing , Xie Wei , Xu Hongxing 
Published: January 2024

AbstractThe superfluorescence effect has received extensive attention due to the many-body physics of quantum correlation in dipole gas and the optical applications of ultrafast bright radiation field based on the cooperative quantum state. Here, we demonstrate not only to observe the superfluorescence effect but also to control the cooperative state of the excitons ensemble by externally applying a regulatory dimension of coupling light fields. A new quasi-particle called cooperative exciton-polariton is revealed in a light-matter hybrid structure of a perovskite quantum dot thin film spin-coated on a Distributed Bragg Reflector. Above the nonlinear threshold, polaritonic condensation occurs at a nonzero momentum state on the lower polariton branch owning to the vital role of the synchronized excitons. The phase transition from superfluorescence to polariton condensation exhibits typical signatures of a decrease of the linewidth, an increase of the macroscopic coherence as well as an accelerated radiation decay rate. These findings are promising for opening new potential applications for super-brightness and unconventional coherent light sources and could enable the exploitation of cooperative effects for quantum optics.
Ac-DEVD-CHO (caspase-3/DEVDase inhibitor) suppresses self-incompatibility–induced programmed cell death in the pollen tubes of petunia (Petunia hybrida E. Vilm.)
Authors: Zakharova Ekaterina Vladimirovna , Demyanchuk Ilya Sergeevich , Sobolev Denis Sergeevich , Golivanov Yaroslav Yurievich , Baranova Ekaterina Nikolaevna , Khaliluev Marat Rushanovich 
Published: January 2024

AbstractProgrammed cell death (PCD) is relevant to many aspects in the growth and development of a plant organism. In their reproduction, many flowering plant species possess self-incompatibility (SI), that is an intraspecific reproductive barrier, which is a genetic mechanism ensuring the avoidance of inbreeding depression by preventing self-pollination. This phenomenon enhances intraspecific variation; however, SI is rather a hindrance for some fruit plant species (such as plum, cherry, and peer trees) rather than an advantage in farming. PCD is a factor of the S-RNase–based SI in Petunia hybrida E. Vilm. The growth of self-incompatible pollen tubes (PTs) is arrested with an increase in the activity of caspase-like proteases during the first hours after pollination so that all traits of PCD—plasma membrane integrity damage, DNA degradation/disintegration, and damage of PT structural organization (absence of vacuoles, turgor disturbance, and separation of cell plasma membrane from the cell wall)—are observable by the moment of PT growth arrest. We succeeded in discovering an additional cytological PCD marker, namely, the formation of ricinosomes in self-incompatible PTs at early stages of PCD. SI is removable by treating petunia stigmas with Acetyl-Asp-Glu-Val-Asp-aldehyde (Ac-DEVD-CHO), an inhibitor of caspase-3/DEVDase, 2 h before a self-incompatible pollination. In this process, the level of caspase-3-like protease activity was low, DNA degradation was absent, PTs grew to the ovary, fertilization was successful, and full-fledged seeds were formed.
Atomically synergistic Zn-Cr catalyst for iso-stoichiometric co-conversion of ethane and CO2 to ethylene and CO
Authors: Yang Ji , Wang Lu , Wan Jiawei , El Gabaly Farid , Fernandes Cauduro Andre L. , Mills Bernice E. , Chen Jeng-Lung , Hsu Liang-Ching , Lee Daewon , Zhao Xiao , Zheng Haimei , Salmeron Miquel , Wang Caiqi , Dong Zhun , Lin Hongfei , Somorjai Gabor A. , Rosner Fabian , Breunig Hanna , Prendergast David , Jiang De-en , Singh Seema , Su Ji 
Published: January 2024

AbstractDeveloping atomically synergistic bifunctional catalysts relies on the creation of colocalized active atoms to facilitate distinct elementary steps in catalytic cycles. Herein, we show that the atomically-synergistic binuclear-site catalyst (ABC) consisting of $${{{{{\rm{Zn}}}}}}^{\delta+}$$

Zn

δ
+

-O-Cr6+ on zeolite SSZ-13 displays unique catalytic properties for iso-stoichiometric co-conversion of ethane and CO2. Ethylene selectivity and utilization of converted CO2 can reach 100 % and 99.0% under 500  °C at ethane conversion of 9.6%, respectively. In-situ/ex-situ spectroscopic studies and DFT calculations reveal atomic synergies between acidic Zn and redox Cr sites. $${{{{{\rm{Zn}}}}}}^{\delta+}$$

Zn

δ
+

($$0 \, < \, \delta \, < \, 2$$
0

<

δ

<

2
) sites facilitate β-C-H bond cleavage in ethane and the formation of Zn-Hδ- hydride, thereby the enhanced basicity promotes CO2 adsorption/activation and prevents ethane C-C bond scission. The redox Cr site accelerates CO2 dissociation by replenishing lattice oxygen and facilitates H2O formation/desorption. This study presents the advantages of the ABC concept, paving the way for the rational design of novel advanced catalysts.
Single-cell analysis of psoriasis resolution demonstrates an inflammatory fibroblast state targeted by IL-23 blockade
Authors: Francis Luc , McCluskey Daniel , Ganier Clarisse , Jiang Treasa , Du-Harpur Xinyi , Gabriel Jeyrroy , Dhami Pawan , Kamra Yogesh , Visvanathan Sudha , Barker Jonathan N. , Smith Catherine H. , Capon Francesca , Mahil Satveer K. 
Published: January 2024

AbstractBiologic therapies targeting the IL-23/IL-17 axis have transformed the treatment of psoriasis. However, the early mechanisms of action of these drugs remain poorly understood. Here, we perform longitudinal single-cell RNA-sequencing in affected individuals receiving IL-23 inhibitor therapy. By profiling skin at baseline, day 3 and day 14 of treatment, we demonstrate that IL-23 blockade causes marked gene expression shifts, with fibroblast and myeloid populations displaying the most extensive changes at day 3. We also identify a transient WNT5A+/IL24+ fibroblast state, which is only detectable in lesional skin. In-silico and in-vitro studies indicate that signals stemming from these WNT5A+/IL24+ fibroblasts upregulate multiple inflammatory genes in keratinocytes. Importantly, the abundance of WNT5A+/IL24+ fibroblasts is significantly reduced after treatment. This observation is validated in-silico, by deconvolution of multiple transcriptomic datasets, and experimentally, by RNA in-situ hybridization. These findings demonstrate that the evolution of inflammatory fibroblast states is a key feature of resolving psoriasis skin.
Rescuing SERCA2 pump deficiency improves bone mechano-responsiveness in type 2 diabetes by shaping osteocyte calcium dynamics
Authors: Shao Xi , Tian Yulan , Liu Juan , Yan Zedong , Ding Yuanjun , Hao Xiaoxia , Wang Dan , Shen Liangliang , Luo Erping , Guo X. Edward , Luo Peng , Luo Wenjing , Cai Jing , Jing Da 
Published: January 2024

AbstractType 2 diabetes (T2D)-related fragility fractures represent an increasingly tough medical challenge, and the current treatment options are limited. Mechanical loading is essential for maintaining bone integrity, although bone mechano-responsiveness in T2D remains poorly characterized. Herein, we report that exogenous cyclic loading-induced improvements in bone architecture and strength are compromised in both genetically spontaneous and experimentally-induced T2D mice. T2D-induced reduction in bone mechano-responsiveness is directly associated with the weakened Ca2+ oscillatory dynamics of osteocytes, although not those of osteoblasts, which is dependent on PPARα-mediated specific reduction in osteocytic SERCA2 pump expression. Treatment with the SERCA2 agonist istaroxime was demonstrated to improve T2D bone mechano-responsiveness by rescuing osteocyte Ca2+ dynamics and the associated regulation of osteoblasts and osteoclasts. Moreover, T2D-induced deterioration of bone mechano-responsiveness is blunted in mice with osteocytic SERCA2 overexpression. Collectively, our study provides mechanistic insights into T2D-mediated deterioration of bone mechano-responsiveness and identifies a promising countermeasure against T2D-associated fragility fractures.
Anisotropic carrier dynamics and laser-fabricated luminescent patterns on oriented single-crystal perovskite wafers
Authors: Ge Chao , Li Yachao , Song Haiying , Xie Qiyuan , Zhang Leilei , Ma Xiaoran , Liu Junfeng , Guo Xiangjing , Yan Yinzhou , Liu Danmin , Zhang Wenkai , Liu Shibing , Liu Yang 
Published: January 2024

AbstractPerovskite materials and their applications in optoelectronics have attracted intensive attentions in recent years. However, in-depth understanding about their anisotropic behavior in ultrafast carrier dynamics is still lacking. Here we explore the ultrafast dynamical evolution of photo-excited carriers and photoluminescence based on differently-oriented MAPbBr3 wafers. The distinct in-plane polarization of carrier relaxation dynamics of the (100), (110) and (111) wafers and their out-of-plane anisotropy in a picosecond time scale were found by femtosecond time- and polarization-resolved transient transmission measurements, indicating the relaxation process dominated by optical/acoustic phonon interaction is related to photoinduced transient structure rearrangements. Femtosecond laser two-photon fabricated patterns exhibit three orders of magnitude enhancement of emission due to the formation of tentacle-like microstructures. Such a ultrafast dynamic study carried on differently-oriented crystal wafers is believed to provide a deep insight about the photophysical process of perovskites and to be helpful for developing polarization-sensitive and ultrafast-response optoelectronic devices.
Self-compliant ionic skin by leveraging hierarchical hydrogen bond association
Authors: Ye Huating , Wu Baohu , Sun Shengtong , Wu Peiyi 
Published: January 2024

AbstractRobust interfacial compliance is essential for long-term physiological monitoring via skin-mountable ionic materials. Unfortunately, existing epidermal ionic skins are not compliant and durable enough to accommodate the time-varying deformations of convoluted skin surface, due to an imbalance in viscosity and elasticity. Here we introduce a self-compliant ionic skin that consistently works at the critical gel point state with almost equal viscosity and elasticity over a super-wide frequency range. The material is designed by leveraging hierarchical hydrogen bond association, allowing for the continuous release of polymer strands to create topological entanglements as complementary crosslinks. By embodying properties of rapid stress relaxation, softness, ionic conductivity, self-healability, flaw-insensitivity, self-adhesion, and water-resistance, this ionic skin fosters excellent interfacial compliance with cyclically deforming substrates, and facilitates the acquisition of high-fidelity electrophysiological signals with alleviated motion artifacts. The presented strategy is generalizable and could expand the applicability of epidermal ionic skins to more complex service conditions.
Humoral profiles of toddlers and young children following SARS-CoV-2 mRNA vaccination
Authors: Nziza Nadège , Deng Yixiang , Wood Lianna , Dhanoa Navneet , Dulit-Greenberg Naomi , Chen Tina , Kane Abigail S. , Swank Zoe , Davis Jameson P. , Demokritou Melina , Chitnis Anagha P. , Fasano Alessio , Edlow Andrea G. , Jain Nitya , Horwitz Bruce H. , McNamara Ryan P. , Walt David R. , Lauffenburger Douglas A. , Julg Boris , Shreffler Wayne G. , Alter Galit , Yonker Lael M. 
Published: January 2024

AbstractAlthough young children generally experience mild symptoms following infection with SARS-CoV-2, severe acute and long-term complications can occur. SARS-CoV-2 mRNA vaccines elicit robust immunoglobulin profiles in children ages 5 years and older, and in adults, corresponding with substantial protection against hospitalizations and severe disease. Whether similar immune responses and humoral protection can be observed in vaccinated infants and young children, who have a developing and vulnerable immune system, remains poorly understood. To study the impact of mRNA vaccination on the humoral immunity of infant, we use a system serology approach to comprehensively profile antibody responses in a cohort of children ages 6 months to 5 years who were vaccinated with the mRNA-1273 COVID-19 vaccine (25 μg). Responses are compared with vaccinated adults (100 μg), in addition to naturally infected toddlers and young children. Despite their lower vaccine dose, vaccinated toddlers elicit a functional antibody response as strong as adults, with higher antibody-dependent phagocytosis compared to adults, without report of side effects. Moreover, mRNA vaccination is associated with a higher IgG3-dependent humoral profile against SARS-CoV-2 compared to natural infection, supporting that mRNA vaccination is effective at eliciting a robust antibody response in toddlers and young children.
Well-defined in-textile photolithography towards permeable textile electronics
Authors: Wang Pengwei , Ma Xiaohao , Lin Zhiqiang , Chen Fan , Chen Zijian , Hu Hong , Xu Hailong , Zhang Xinyi , Shi Yuqing , Huang Qiyao , Lin Yuanjing , Zheng Zijian 
Published: January 2024

AbstractTextile-based wearable electronics have attracted intensive research interest due to their excellent flexibility and breathability inherent in the unique three-dimensional porous structures. However, one of the challenges lies in achieving highly conductive patterns with high precision and robustness without sacrificing the wearing comfort. Herein, we developed a universal and robust in-textile photolithography strategy for precise and uniform metal patterning on porous textile architectures. The as-fabricated metal patterns realized a high precision of sub-100 µm with desirable mechanical stability, washability, and permeability. Moreover, such controllable coating permeated inside the textile scaffold contributes to the significant performance enhancement of miniaturized devices and electronics integration through both sides of the textiles. As a proof-of-concept, a fully integrated in-textiles system for multiplexed sweat sensing was demonstrated. The proposed method opens up new possibilities for constructing multifunctional textile-based flexible electronics with reliable performance and wearing comfort.
Metabolic changes in response to varying whole-grain wheat and rye intake
Authors: Koistinen Ville M. , Haldar Sumanto , Tuomainen Marjo , Lehtonen Marko , Klåvus Anton , Draper John , Lloyd Amanda , Beckmann Manfred , Bal Wendy , Ross Alastair B. , Brandt Kirsten , Fawcett Lee , Seal Chris , Hanhineva Kati 
Published: January 2024

AbstractEpidemiological studies have shown associations between whole-grain intake and lowered disease risk. A sufficient level of whole-grain intake to reach the health benefits has not been established, and there is limited knowledge about the impact of whole-grain intake on metabolite levels. In this clinical intervention study, we aimed to identify plasma and urine metabolites associated with two different intake levels of whole-grain wheat and rye and to correlate them with clinical plasma biomarkers. Healthy volunteers (N = 68) were divided into two groups receiving either whole-grain wheat or whole-grain rye in two four-week interventions with 48 and 96 g/d of whole grains consumed. The metabolomics of the plasma samples was performed with UPLC–QTOF-MS. Plasma alkylresorcinols were quantified with GC-MS and plasma and urinary mammalian lignans with HPLC-ECD. The high-dose intervention impacted the metabolite profile, including microbial metabolites, more in the rye-enriched diet compared with wheat. Among the increased metabolites were alkylresorcinol glucuronides, sinapyl alcohol, and pipecolic acid betaine, while the decreased metabolites included acylcarnitines and ether lipids. Plasma alkylresorcinols, urinary enterolactone, and total mammalian lignans reflected the study diets in a dose-dependent manner. Several key metabolites linked with whole-grain consumption and gut microbial metabolism increased in a linear manner between the two interventions. The results reveal that an increase in whole-grain intake, particularly rye, is strongly reflected in the metabolite profile, is correlated with clinical variables, and suggests that a diet rich in whole grains promotes the growth and/or metabolism of microbes producing potentially beneficial microbial metabolites.