bluuebunny/crossref_metadata_2025_split huggingface dataset:
Process production process quality prediction model based on LSTM optimized by SSA
Authors: Sun Dong , Li Zhimin , Wang Mingjun , Zheng Huali , Yan Wenkai , Ye Chunming 
Published: December 2023

Abstract
Process production in manufacturing industry has the characteristics of strong continuity and complex timing coupling. To solve the problem of gradient explosion or disappearance when using traditional neural network for multi-step prediction, a multi-step time series prediction model based on sparrow search algorithm and long short-term memory network is constructed. The constructed model uses the sparrow search algorithm to optimize the learning rate, the number of nodes in two hidden layers and the number of iterations of the LSTM model to obtain the optimal network. The process index data of a domestic manufacturing enterprise were selected to achieve multi-step prediction, and five indexes were evaluated: mean square error (MSE), root mean square error (RMSE), mean absolute error (MAE), mean absolute percentage error (MAPE) and R-squared coefficient. The result shows that the constructed SSA-LSTM model has the lowest prediction error, the largest R-squared coefficient and more accurate prediction value, which can provide ideas and ways for enterprises to adjust production plans in advance.
Outcomes of fertility preservation before or after anticancer treatments in young breast cancer patients and survivors: a single-center retrospective study and clinical experiences
Authors: Wang Luyao , Chu Yifan , Xie Jiaxin , Yang Shulin , Yue Jing 
Published: December 2023

Abstract
Background
Fertility preservation (FP) is gradually becoming a crucial cure during fertility counseling for all breast cancer (BC) women of reproductive age, but certain limiting factors hinder patients' decisions. This study aimed to collect cases involving fertility preservation before anticancer treatments and assisted reproductive technology (ART) after anticancer therapies in young breast cancer (BC) patients and survivors and to share some clinical experiences.
Methods
We retrospectively analyzed 18 BC patients who underwent FP before (neo)adjuvant chemotherapy and 8 survivors who chose ART after completing anticancer treatments in a single reproductive medicine center between January 2015 and June 2023. Baseline characteristics and outcomes of FP and ART were analyzed.
Results
8 survivors of a median age of 35.5 years (range 32.3–41.0 years) underwent ART after anticancer therapies and behaved diminished ovarian reserve (DOR) or even premature ovarian insufficiency (POI) with undesirable outcomes. Receiving FP before (neo)adjuvant chemotherapy in 18 patients does not delay subsequent treatments, patients receiving neoadjuvant chemotherapy tend to prefer RS-COS protocol that shorten the time from diagnosis to initiation of chemotherapy (median days 26.0 vs. 42.0, p = 0.002) compared to the majority of patients receiving cCOS protocol, and there is no difference in other FP results. COS with letrozole can control the serum estradiol level in a relatively safe condition. During a median follow-up period of 17.5 months (range 8.8–31.0 months), only 1 (5.6%) woman suffered recurrence with bone metastasis when she received neoadjuvant chemotherapy after FP, 2 (11.1%) patients experienced ovarian hyperstimulation syndrome (OHSS) after COS, and 3 (37.5%) survivors had a live birth after ART.
Conclusions
Embryo and oocyte cryopreservation after COS based on letrozole is a preferred and optimal FP option for young BC patients before (neo)adjuvant chemotherapy. Using ART to get pregnant in BC survivors is feasible and not associated with adverse cancer outcomes. It is important that these patients are closely monitored to reduce the potential risks of OHSS and recurrence.
Mechanism of regulation of KIF23 on endometrial cancer cell growth and apoptosis.
Authors: Zhuang Ruiying , Liu Haiyan 
Published: December 2023

Abstract
Objective Endometrial cancer, a malignant tumor in females, is increasing globally. One of the most frequent gynecological cancers. While early-stage endometrial cancers can often be cured through uterine extirpation, those diagnosed at a later stage have a poor prognosis and face treatment challenges. Consequently, further research is required to develop primary prevention strategies for high-risk women and enhance survival rates among those with endometrial cancer. Therefore, gene therapy targeting KIF23 holds promise as a advance strategy to treating endometrial cancer.Method We utilized immunohistochemistry, Western blotting, and PCR to observe the expression of KIF23 and its associated pathway factors in endometrial cancer tissue (Ishikawa, SNGM cells, respectively). The functional roles of KIF23 were investigated through CCK-8, colony-forming proliferation assays, Transwell migration assays, and xenotransplantation in mice.Results Immunohistochemistry analysis revealed variation in the expression ranges of KIF23 between endometrial cancer tissue and normal endometrium tissue. KIF23 downregulated reduced BAX, caspase-3 protein expression while also increasing BCL-2 protein expression. Furthermore, knockout KIF23 hinders endometrial cancer cell proliferation and migration but promotes cell death. Mechanistically, our study provides evidence that KIF23 facilitates endometrial cancer cell proliferation via activating the ERK and AKT/PI3K pathways,while concurrently impeding programmed cell death in endometrial cancer.Conclusion Our study provides evidence supporting that KIF23 knockdown inhibits endometrial cancer. This provides valuable evidence for future research into potential treatments for this type of cancer.
An overpartition analogue of Bressoud's conjecture for even moduli
Authors: Chen Y.H. , Gu T.T. , He Thomas Y. , Tang F. , Wei J.J. 
Published: December 2023

Abstract
In 1980, Bressoud conjectured a combinatorial identity $A_j=B_j$ for $j=0$ or $1$. In this paper, we introduce a new partition function $\overline{B}_0$ which can be viewed as an overpartition analogue of the partition function $B_0$. An overpartition is apartition such that the last occurrence of a part can be overlined. We build a bijection to get a relationship between $\overline{B}_0$ and $B_1$, based on which an overpartition analogue of Bressoud's conjecture for $j=0$ is obtained.
AMS Classifications: 05A17, 11P84
Evaluation of the Influence of Ultrasonic Vibration on Physical, Tensile, and Morphological Properties of Fused Deposition Modeled Specimens
Authors: Quader Raihan , Klinstein Leo , Grewell David , Narayanan Lokesh karthik 
Published: December 2023

Abstract
The use of fused deposition modeling (FDM) in printing polymers for various applications has been ever increasing. However, its utilization in printing polymers for high-strength and superior surface finish applications is still a challenge, primarily due to process intrinsic defects i.e., voids between the layers and the rough exterior arising from unrestrained deposition of molten polymer. This research hypothesizes that application of ultrasonic vibration (USV) post-fabrication could minimize these shortcomings. For this investigation, ASTM D638 Type IV samples were FDM printed using Poly(lactic) Acid (PLA). Through screening experiments, an optimized set of ultrasonic parameters was determined. Then, the effect of both-sided ultrasonic application was characterized. Subsequently, the impact of USV on the samples’ physical, tensile, and morphological properties was examined by varying the layer height, infill patterns, and % infill density. Up to 70% roughness reduction was observed as a result of post-FDM ultrasonic application. Additionally, the tensile strength of the samples increased by up to 15.31%. Moreover, for some lower % infill samples, post-ultrasonic tensile strengths were higher than 100% infill control samples. Analysis of scanning electron microscopy (SEM) and X-ray computed tomography (CT) imagery indicated enhanced layer consolidation and reduced void presence in samples treated with ultrasonic. The combination of ultrasonic-generated heat and downward pressure promoted a synergistic squeeze flow and intermolecular diffusion across consecutive layers of polymers. As a result, increased tensile strength and surface finish were achieved while dimensional change was marginal.
Evaluation of the results of deviated nasal septum correction on nasal respiratory disorders and headache
Authors: Moufti Mayssa , Johari Massa , Nahas Louei Darjazini 
Published: December 2023

Abstract
Introduction: Deviated nasal septum is a common problem in the general population. Therefore, its correction is one of the most common surgical procedures in otolaryngology and facial plastic surgery. The importance of our study comes from the need to highlight the results of septoplasty in patients. And know the effect of a deviated nasal septum on patients’ quality of life and compare it with their quality of life after surgery.
Materials and Methods: A prospective study was conducted targeting patients with a deviated nasal septum who underwent septoplasty in Al-Mujtahid Hospital (Damascus Hospital) and Al-Hilal Hospital. Data were collected between the end of October 2022 and the beginning of April 2023. The sample size was 120 patients who matched the study inclusion criteria and were followed up for three months after surgery.
Results: Our study included 120 patients who had suffered from a deviated nasal septum. The average age of these patients was 25.69 years. The number of male patients was 51, representing 43%, while the number of female patients was 69, representing 58%. The primary reason for performing septoplasty in the majority of patients was difficulty breathing/nasal obstruction91 (76%). Surgery was performed openly in 111 (93%) cases, while it was performed laparoscopically in only 9 (8%). Only 12 patients suffered from epistaxis (9%).
Conclusion: The results in our study indicated that performing a septoplasty operation in addition to a rhinoplasty operation at the same time gave a difference in improving symptoms. The same applies when the septoplasty operation was combined with a turbinectomy operation, as the patients’ nasal obstructive symptoms improved in addition to an improvement in headaches. They have.
Quarter Car Suspension System Modelling, Simulation, And Performance Analysis under Dynamic Conditions
Authors: Bezabh walelign Wudu 
Published: December 2023

Abstract
The motor vehicle is constructed up of numerous systems. The suspension system is one of them. The primary purposes of the automotive suspension system are to effectively isolate the vehicle from road disturbances and to provide stability, directional control, and vehicle support during handling movements. The suspension system must strike a compromise between ride quality and handling ability of the car. This study uses a linear quadratic regulator (LQR) controller to analyse the active suspension system and the passive suspension system. This study aims to simulate and analysis of the vehicle performance by construct a MATLAB/SIMULINK on quarter automobile model. For this research, the sinusoidal roads and a random road inputs are used to study the effect of road irregularity and vehicle speeds on the performance of the suspension system. purposely 30,60,90 and 120km/hr are selected for this study. The passive suspension system and the LQR controller's performance are contrasted. The simulation's findings demonstrate how the LQR controller enhances ride comfort and wheel deflection in automobiles suspension system at all road inputs even at high vehicle speed the LQR controller help the system for better ride comfort of the passengers and help the system to better life of the vehicle.
Current Regulatory Framework and Challenges for the Approval of Complex
Generics in the US and the EU
Authors: Patil Sharvari , Kumar Sandeep , Rao Dasari Mallikarjuna , Rewatkar Kishore 
Published: December 2023

Abstract:
The pharmaceutical industry is witnessing a growing demand for complex generic products, which are generic versions of drugs that possess
complex formulations, delivery systems, or active ingredients. However, the approval process for these complex generic products poses unique
challenges compared to traditional generics. There is no specific regulatory procedure available for the approval of complex generics, unlike smallmolecule
generics and biosimilars. This led to controversial arguments in the past about the scientific evidence needed for applications, which led
to lengthy approval processes. The regulatory frameworks that are currently being used for complex generics are debatable and unclear.
Complexity in the molecular structure, mechanism of action, route of delivery, and complex manufacturing process makes proving bioequivalence
and pharmaceutical equivalence difficult. There is a need for harmonization of the regulatory framework by the agencies to help the generic
manufacturers by providing scientific advice, defining the submission requirements for complex products, and fastening the approval process.

:
This review begins by discussing the regulatory landscape surrounding complex generic products in various regions, including the United States
and Europe. It examines the specific guidelines and requirements set forth by regulatory authorities to ensure the safety, efficacy, and quality of
these products. Additionally, the review explores the differences in terminology and definitions used to classify complex generics across different
jurisdictions. Furthermore, it delves into the challenges faced by both regulatory agencies and pharmaceutical companies in evaluating and
approving complex generic products. These challenges include establishing appropriate bioequivalence criteria, determining interchangeability
with the reference product, addressing patent and exclusivity issues, and ensuring consistent quality throughout the product lifecycle. The impact of
these challenges on market entry and competition is also discussed. The review highlights the need for harmonization and streamlining of
regulations for complex generic products worldwide. It emphasizes the importance of clear and consistent guidelines to enable timely approvals,
foster innovation, and facilitate patient access to affordable alternatives.
Biphasic Hormetic-like Effect of Lebecetin, a C-type Lectin of Snake
Venom, on Formalin-induced Inflammation in Mice
Authors: Belardo Carmela , Jebali Jed , Boccella Serena , Infantino Rosmara , Fusco Antimo , Perrone Michela , Bonsale Roozbe , Manzo Iolanda , Iannotta Monica , Scuteri Damiana , Ferraraccio Franca , Panarese Iacopo , Ferrara Giovanna , Guida Francesca , Luongo Livio , Palazzo Enza , Srairi-Abid Najet , Marrakchi Naziha , Maione Sabatino 
Published: December 2023

Background:
Integrins, important extracellular matrix (ECM) receptor proteins, are affected
by inflammation and can participate in the maintenance of many painful conditions. Although they
are ubiquitous and changeable across all cell types, the roles of these cell adhesion molecules in pathological
pain have not been fully explored.

Objective:
We evaluated the effects of the subcutaneous injection of lebecetin, a C-type lectin isolated
from Macrovipera lebetina snake venom, previously reported to inhibit α5β1 and αv integrin activity, on
different components of inflammation induced by the formalin administration in the hind paw of mice.

Methods:
The formalin-induced nocifensive behavior, edema, and histopathological changes in the
hind paw associated with cytokine, iNOS, and COX2 expression, nociceptive-specific neuron activity,
and microglial activation analysis in the spinal cord were evaluated in mice receiving vehicle or lebecetin
pretreatment.

Results:
Lebecetin inhibited the nocifensive responses in the formalin test, related edema, and cell infiltration
in the injected paw in a biphasic, hormetic-like, and dose-dependent way. According to that
hormetic trend, a reduction in pro-inflammatory cytokines IL-6, IL-8, and TNF-alpha and upregulation
of the anti-inflammatory cytokine IL-10 in the spinal cord were found with the lowest doses of lebecetin.
Moreover, COX2 and iNOS expression in serum and spinal cord followed the same biphasic
pattern of cytokines. Finally, nociceptive neurons sensitization and activated microglia were normalized
in the dorsal horn of the spinal cord by lebecetin.

Conclusion:
These findings implicate specific roles of integrins in inflammation and tonic pain, as
well as in the related central nervous system sequelae.
Effect of Moringa (Moringa oleifera) leaves on increasing hemoglobin level of female adolescents
Authors: Yulastini Fitria , Makiyah SN Nurul , Mawarti Retno 
Published: December 2023

<p align="center"><strong>ABSTRACT</strong></p><p><strong>Background</strong>: Iron deficiency anemia is a dominant cause of anemia in the world, and it is one of the major nutritional problems in Indonesia with high prevalence in female adolescents, which reached 22.7%. Moringa plant (<em>Moringa oleifera</em>) contains rich amount of protein, amino acid, mineral, and vitamin.The use of moringa leaves as an herbal treatment has been developed, with one of its main objectives is to increase the hemoglobin level.</p><p><strong>Objective</strong>: To analyze the effect of moringa <em>(Moringa oleifera) </em>leaves capsule on the hemoglobin level of female adolescents.</p><p><strong>Met</strong><strong>h</strong><strong>od</strong>: This was a true experimental study with randomized controlled trial design and simple random sampling. Research samples were 61 anemic female adolescents that were classified into two groups. 31 girls were selected as treatment group where they consumed moringa leaves capsules, and the other 30 girls received iron supplements in control group. The intervention was done twice per day for 21 days. Data of hemoglobin level was analyzed using independent t-test<em>.</em></p><p><strong>Results</strong>: Hemoglobin level in treatment group before the intervention was 10.75±0.94 gr/dl and it increased to 12.58±0.99 (p-value= 0.000) after the intervention. The level of the control group also increased after intervention with the p-valueof 0.000. The mean hemoglobin level increase in treatment and control groups were 1.82 gr/dland 1.40 gr/dl, respectively. There was a significant difference between hemoglobin level increase between both groups with the p-valueof 0.039(&lt;0.05).</p><p><strong>Conclusion</strong>: The hemoglobin level of female adolescents who consumed moringa (<em>Moringa oleifera</em>) leaves capsules was higher than the ones who only took iron supplements.</p><p> </p><p><strong>Keywords</strong><strong> </strong>: Moringa leaves (<em>Moringa oleifera</em>); iron supplement; hemoglobin level; female adolescent</p>
Hyaluronidase for Dermal Filler Complications: Review of Applications and Dosage Recommendations
Authors: Kroumpouzos George , Treacy Patrick 
Published: December 2023

Background
Hyaluronidase (Hyal) can reverse complications of hyaluronic acid (HA) fillers, which has contributed substantially to the popularity of such procedures. Still, there are differing opinions regarding Hyal treatment, including dosage recommendations in filler complication management.

Objective
We aimed to address unanswered questions regarding Hyal treatment for HA filler complications, including timing and dosage, skin pretesting, properties of various Hyals and interactions with HA gels, and pitfalls of the treatment.

Methods
PubMed and Google Scholar databases were searched from inception for articles on Hyal therapy for filler complications. Articles were evaluated regarding their contribution to the field. The extensive literature review includes international leaders’ suggestions and expert panels’ recommendations.

Results
There are limited controlled data but increasing clinical experience with Hyal treatment. The currently used Hyals provide good results and have an acceptable safety profile. Nonemergent complications such as the Tyndall effect, noninflamed nodules, and allergic or hypersensitivity reactions should be treated with low or moderate Hyal doses. Hyal should be considered with prior or simultaneous oral antibiotic treatment in managing inflammatory nodules. Hyal may be tried for granulomas that have not responded to intralesional steroids. Emergent complications such as vascular occlusion and blindness require immediate, high-dose Hyal treatment. Regarding blindness, the injection technique, retrobulbar versus supraorbital, remains controversial. Ultrasound guidance can increase the efficacy of the above interventions.

Conclusions
Hyal is essential in aesthetic practice because it can safely treat most HA filler complications. Immediate Hyal treatment is required for emergent complications. Aesthetic practitioners should be versed in using Hyal and effective dosage protocols.
Evaluating the Appropriateness of Podcasts to Improve the Knowledge and Awareness of Selected Health Topics Among Undergraduate General Nursing Students: Protocol for an International Feasibility Study
Authors: Denny Alanna , Curtin Brian , Taylor-Robinson Simon , Chirambo Griphin Baxter , Cilliers Liezel , Wu Tsung-Shu Joseph , O'Meara Ciara , Booth Richard , O'Donoghue John 
Published: December 2023

Background
Podcasts have proven to be a successful alternative source of educational material for students. Given the ability to listen to podcasts 24/7 and while on the go, this technology has the potential to provide informative and educational material to a large number of people at any given time. Podcasts are usually freely available on commonly used mobile devices, such as smartphones, laptops, and tablets.

Objective
This paper describes the impact of health-related podcasts as an intervention tool to support the knowledge and awareness of nursing students on a given topic.

Methods
Pre- and postpodcast questionnaires will gather data regarding the participants’ knowledge and awareness of two topics—gestational diabetes and mental health. This intervention will be tested on general nursing undergraduate students. The total number of students (N=2395) from the participating universities are broken down as follows: (1) University College Cork (n=850) and the University of Galway (n=450) in Ireland, (2) Mzuzu University in Malawi (n=719), and (3) University of Fort Hare in South Africa (n=376).

Results
The study received ethical approval from the University College Cork Ethics Committee (2022-027A1). The approval obtained from University College Cork sufficed as ethics coverage for the University of Galway in Ireland. Ethics approval was also received from the Mzuzu University Research Ethics Committee (ID MZUNIREC/DOR/23/28) and the Inter-Faculty Research Ethics Committee of the University of Fort Hare (ID CIL002-21). Data collection is currently underway and will continue until the end of February 2024. The quantitative and qualitative data are expected to be analyzed in March 2024.

Conclusions
Results from this study will allow for an investigation into the impact of podcasts in different settings: a high-income country (Ireland), an upper-middle–income country (South Africa), and a low-to-middle–income country (Malawi). The data gathered from this feasibility study will provide more clarity on the potential utility of podcasts as an intervention tool. We will gather data regarding listener demographics (eg, country of residence, age, gender, and year of study).

International Registered Report Identifier (IRRID)
DERR1-10.2196/50735