bluuebunny/crossref_metadata_2025_split huggingface dataset:
Impact of COVID-19-related methadone regulatory flexibilities: views of state opioid treatment authorities and program staff
Authors: Mitchell Shannon Gwin , Jester Julia , Gryczynski Jan , Whitter Melanie , Fuller Douglas , Halsted Caroline , Schwartz Robert P. 
Published: October 2023

Abstract
Background
During the COVID-19 pandemic, federal regulations in the USA for methadone treatment of opioid use disorder (OUD) were temporarily revised to reduce clinic crowding and promote access to treatment.

Methods
As part of a study seeking to implement interim methadone without routine counseling to hasten treatment access in Opioid Treatment Programs with admission delays, semi-structured qualitative interviews were conducted via Zoom with participating staff (N = 11) in six OTPs and their State Opioid Treatment Authorities (SOTAs; N = 5) responsible for overseeing the OTPs’ federal regulatory compliance. Participants discussed their views on the response of OTPs in their states to the pandemic and the impact of the COVID-related regulatory flexibilities on staff, established patients, and new program applicants. Interviews were audio recorded, transcribed, and a content analysis was conducted using ATLAS.ti.

Results
All SOTAs requested the blanket take-home exemption and supported the use of telehealth for counseling. Participants noted that these changes were more beneficial for established patients than program applicants. Established patients were able to obtain a greater number of take-homes and attend individual counseling remotely. Patients with limited resources had greater difficulty or were unable to access remote counseling. The convenience of intake through telehealth did not extend to new program applicants because the admission physical exam requirement was not waived.

Conclusions
The experienced reflections of SOTAs and OTP providers on methadone practice changes during the COVID-19 pandemic offer insights on SAMHSA’s proposed revisions to its OTP regulations.
Trial registration Clinicaltrials.gov # NCT04188977.
Interaction of Clostridioides difficile infection with frailty and cognition in the elderly: a narrative review
Authors: Fernandez-Cotarelo Maria-Jose , Jackson-Akers Jasmine Y. , Nagy-Agren Stephanie E. , Warren Cirle A. 
Published: October 2023

Abstract
Purpose
Clostridioides difficile infection (CDI) is the leading cause of antibiotic-related diarrhea and healthcare-associated infections, affecting in particular elderly patients and their global health. This review updates the understanding of this infection, with focus on cognitive impairment and frailty as both risk factors and consequence of CDI, summarizing recent knowledge and potential mechanisms to this interplay.

Methods
A literature search was conducted including terms that would incorporate cognitive and functional impairment, aging, quality of life, morbidity and mortality with CDI, microbiome and the gut–brain axis.

Results
Advanced age remains a critical risk for severe disease, recurrence, and mortality in CDI. Observational and quality of life studies show evidence of functional loss in older people after acute CDI. In turn, frailty and cognitive impairment are independent predictors of death following CDI. CDI has long-term impact in the elderly, leading to increased risk of readmissions and mortality even months after the acute event. Immune senescence and the aging microbiota are key in susceptibility to CDI, with factors including inflammation and exposure to luminal microbial products playing a role in the gut–brain axis.

Conclusions
Frailty and poor health status are risk factors for CDI in the elderly. CDI affects quality of life, cognition and functionality, contributing to a decline in patient health over time and leading to early and late mortality. Narrative synthesis of the evidence suggests a framework for viewing the cycle of functional and cognitive decline in the elderly with CDI, impacting the gut–brain and gut–muscle axes.
New evidence in the relationship between trade openness and food security in Sub-Saharan Africa
Authors: Gnedeka Kodjo Théodore , Wonyra Kwami Ossadzifo 
Published: October 2023

Abstract
Background
Since 2015, food insecurity has been a more serious threat than the previous years with a record high observed from the year 2020 onwards, especially in developing countries. This record could be due to response measures, notably the closure of borders due to the COVID-19 pandemic. This implies that trade openness have played an important role in achieving food security in the world. However, the debate on the effect of trade openness on food security remains no consensus in the economic literature. It is in this context that this paper aims to re-examine the effect of trade openness on food security in sub-Saharan African countries.

Methods
Panel data covering 37 Sub-Saharan African countries over the period from 2004 to 2018 were mobilized. We use a dynamic empirical model based on the system Generalized Method of Moment (GMM) to control the unobserved heterogeneity and potential endogeneity of the explanatory variables. As food security is a multidimensional concept, we used four indicators (“average dietary energy supply adequacy”, “average protein supply”, “per capita food supply variability”, and “share of dietary energy supply”) to capture food security. To improve the robustness of the empirical effect of openness on food security, we also used globalization as an alternative factor to trade openness.

Results
The empirical results show that trade openness significantly improves food security in 37 Sub-Saharan African countries. However, in the presence of political instability, a deterioration of the food security situation is observed. The results reveal also that the quality of institutions, economic growth, remittances, human capital, and the importance of the agricultural sector are also factors favouring the level of food security in sub-Saharan Africa countries.

Conclusion
Any policy aimed at trade openness must consider the quality of institutions to achieve the expected results.
Untargeted plasma metabolomics and risk of colorectal cancer—an analysis nested within a large-scale prospective cohort
Authors: Vidman Linda , Zheng Rui , Bodén Stina , Ribbenstedt Anton , Gunter Marc J. , Palmqvist Richard , Harlid Sophia , Brunius Carl , Van Guelpen Bethany 
Published: October 2023

AbstractBackgroundColorectal cancer (CRC) is a leading cause of cancer-related death worldwide, but if discovered at an early stage, the survival rate is high. The aim of this study was to identify novel markers predictive of future CRC risk using untargeted metabolomics.MethodsThis study included prospectively collected plasma samples from 902 CRC cases and 902 matched cancer-free control participants from the population-based Northern Sweden Health and Disease Study (NSHDS), which were obtained up to 26 years prior to CRC diagnosis. Using reverse-phase liquid chromatography–mass spectrometry (LC–MS), data comprising 5015 metabolic features were obtained. Conditional logistic regression was applied to identify potentially important metabolic features associated with CRC risk. In addition, we investigated if previously reported metabolite biomarkers of CRC risk could be validated in this study population.ResultsIn the univariable analysis, seven metabolic features were associated with CRC risk (using a false discovery rate cutoff of 0.25). Two of these could be annotated, one as pyroglutamic acid (odds ratio per one standard deviation increase = 0.79, 95% confidence interval, 0.70–0.89) and another as hydroxytigecycline (odds ratio per one standard deviation increase = 0.77, 95% confidence interval, 0.67–0.89). Associations with CRC risk were also found for six previously reported metabolic biomarkers of prevalent and/or incident CRC: sebacic acid (inverse association) and L-tryptophan, 3-hydroxybutyric acid, 9,12,13-TriHOME, valine, and 13-OxoODE (positive associations).ConclusionsThese findings suggest that although the circulating metabolome may provide new etiological insights into the underlying causes of CRC development, its potential application for the identification of individuals at higher risk of developing CRC is limited.
Content validation of a mental wellness measuring instrument for adolescents living with HIV: a modified delphi study
Authors: Orth Zaida , van Wyk Brian 
Published: October 2023

AbstractA growing body of evidence suggests that improving the mental wellness of adolescents living with HIV (ALHIV) will also result in improved adherence to antiretroviral therapy (ART), as well as improving their general health and wellbeing as they age into adulthood. However, to develop effective strategies and interventions aimed at improving mental wellness, we require age and culturally appropriate instruments to build an evidence base. Currently, there is a lack of mental wellness measures developed for ALHIV, especially in the African context. To address this gap, we developed a measure of mental wellness following modified guidelines set out by DeVellis [1] and Godfred et al. as a guiding framework [2]; (1) Identifying the gap, (2) Set the theoretical foundations and identify domains and (3); Instrument development and initial validation. For the first two steps, we conducted a systematic review, photovoice study and integrative review – which we briefly describe as the findings have been published. Following this we describe the processes to develop the instrument and to establish content validity through a modified Delphi Study. Through this process we were able to refine the instrument which will be subject to further testing.Implications and Contribution: This study aims to add to the body of knowledge on promoting mental health (mental wellness) among adolescents living with HIV in South Africa through developing an appropriate and valid measure of mental wellness for this population. This study reports on the results of a Delphi Study aimed at improving the content validity of the instrument Mental Wellness Measure for Adolescents Living with HIV (MWM-ALHIV).
Seismic signature detection during the 2018 Anak Krakatau flank collapse and tsunami using seismic amplitudes from regional-scale monitoring
Authors: Permana Theodorus , Yatimantoro Tatok , Handayani Asteria Satyaning 
Published: October 2023

AbstractOn 22 December 2018, the major flank collapse of Anak Krakatau volcano generated a tsunami that struck the surrounding coasts of Java and Sumatra islands in Indonesia without warning. It was later suggested that the corresponding seismic event lacked the body-wave arrivals typical of tectonic earthquakes, causing difficulties for the automated detection system to recognize the event. We explore the possibility of detecting the seismic signature of such events without relying on the arrival times of body waves, by measuring seismic amplitudes in a regional seismic network at the expected arrival times from a fixed, potential source and comparing them to the theoretical attenuation of surface waves. We propose a fast detection method and evaluate the method using seismograms recorded during the flank collapse and tsunami episode as well as several known tectonic earthquakes. Detailed examinations of the detection results confirm the seismic signatures of the flank collapse and teleseismic events as suggested by previous studies. We also find more seismic signatures suggesting the occurrence of two possible smaller collapse events and variations in the eruptive activity related to the major flank collapse, as well as body and surface wave signals from two teleseismic earthquakes that were present during this episode. Finally, we construct a timeline of events during this devastating episode, combining our results with previous studies as well as insights from weather radar observations. With the ability to detect and discriminate various types of seismic events from each other, the detection method can be useful in assisting the existing monitoring and early warning systems in detecting major volcano-related tsunamigenic events.
Graphical Abstract
Hybrid delivery of cluster-set resistance training for individuals previously treated for lung cancer: the results of a single-arm feasibility trial
Authors: Fairman C. M. , Owens O. L. , Kendall K. L. , Steele J. , Schumpp A. R. , Latella C. , Jones M. T. , Marcotte L. , Dawson J. M. , Peddle-McIntyre C. M. J. , McDonnell K. K. 
Published: October 2023

Abstract
Background
Individuals with non-small cell lung cancer (NSCLC) are burdened by long-lasting symptoms (e.g., dyspnea and fatigue) post-treatment. These symptoms often reduce physical activity levels and increase the risk of functional decline. Though we have previously proposed cluster-set resistance training to mitigate symptom burden in lung cancer, there is currently no data on the feasibility or acceptability of this mode of exercise in cancer. Therefore, the purpose of this study was to investigate the feasibility and acceptability of a hybrid-delivery home-based cluster-set resistance training program in individuals with NSCLC stages I–III (i.e., early stage).

Methods
This study aimed to recruit individuals with NSCLC stages I–III post-treatment to participate in 8 weeks of home-based resistance training, 3 days per week. The program included supervised sessions in the participants’ homes and virtual supervision via videoconferencing. The primary outcome measure of feasibility was evaluated through recruitment, retention, and intervention fidelity (i.e., proportion of exercise completed, relative to what was prescribed). Intervention acceptability (i.e., ease and quality of virtual delivery, level of difficulty, and home-based approach) was assessed using a 4-point Likert-type scale from “strongly disagree” to “strongly agree”.

Results
Fourteen participants were recruited over a 6-month period, with 11 completing the intervention (2 withdrew due to unrelated illness, 1 withdrew due to requiring active treatment), yielding a retention rate of 79%. Characteristics of the participants who completed the intervention (n = 11) were as follows: mean age: 71 ± 10 years, mean BMI: 29.1 ± 6.5, and average time since diagnosis was 62 ± 51 months. Of completers, 27% were male, and 36% were Black; 10 were stage I (91%), and one was stage II (9%). Mean session attendance was 86.4 ± 9.5%. Mean intervention fidelity was 83.1 ± 13.1%. With regard to acceptability,  > 90% of participants positively rated all aspects of the intervention delivery. No adverse events related to exercise were recorded.

Conclusions
The hybrid delivery of a home-based resistance exercise program for individuals previously treated for early-stage NSCLC was found to be safe and feasible. Adaptations to the program for future interventions are required, particularly surrounding resistance exercise programming, and intervention delivery with home visits.

Trial registration
ClinicalTrials.gov: NCT05014035. Registered January 20, 2021.
Prioritizing real estate enterprises based on credit risk assessment: an integrated multi-criteria group decision support framework
Authors: Chen Zhen-Song , Zhou Jia , Zhu Chen-Ye , Wang Zhu-Jun , Xiong Sheng-Hua , Rodríguez Rosa M. , Martínez Luis , Skibniewski Mirosław J. 
Published: October 2023

AbstractCredit risk assessment involves conducting a fair review and evaluation of an assessed subject’s solvency and creditworthiness. In the context of real estate enterprises, credit risk assessment provides a basis for banks and other financial institutions to choose suitable investment objects. Additionally, it encourages real estate enterprises to abide by market norms and provide reliable information for the standardized management of the real estate industry. However, Chinese real estate companies are hesitant to disclose their actual operating data due to privacy concerns, making subjective evaluation approaches inevitable, occupying important roles in accomplishing Chinese real estate enterprise credit risk assessment tasks. To improve the normative and reliability of credit risk assessment for Chinese real estate enterprises, this study proposes an integrated multi-criteria group decision-making approach. First, a credit risk assessment index for Chinese real estate enterprises is established. Then, the proposed framework combines proportional hesitant fuzzy linguistic term sets and preference ranking organization method for enrichment evaluation II methods. This approach is suitable for processing large amounts of data with high uncertainty, which is often the case in credit risk assessment tasks of Chinese real estate enterprises involving massive subjective evaluation information. Finally, the proposed model is validated through a case study accompanied by sensitivity and comparative analyses to verify its rationality and feasibility. This study contributes to the research on credit assessment for Chinese real estate enterprises and provides a revised paradigm for real estate enterprise credit risk assessment.
The consequences of task-supported language teaching via social media on academic engagement, emotion regulation, willingness to communicate, and academic well-being from the lens of positive psychology
Authors: Alazemi Asmaa Falah Theiyab , Gheisari Asma , Patra Indrajit 
Published: October 2023

AbstractAlthough TBLT has been the subject of many prior studies, no research has addressed the impact of TBLT through social media (SM), specifically the Telegram app, on academic engagement, emotion regulation, willingness to communicate (WTC), and academic well-being. To reach this goal, a convenience sampling method was used to select 58 Iranian intermediate EFL learners out of 83 based on their Oxford Quick Placement Test performance. The selected learners were randomly assigned to the control group (CG) and experimental group (EG). Pretests were conducted to measure both groups’ academic engagement, emotion regulation, WTC, and academic well-being. During the treatment, the EG received treatment using the Telegram app and the LMS, while the CG only utilized the LMS without any social media assistance. After the treatment, posttests were administered to evaluate the performance of both groups. The results of the data analysis revealed a significant difference in the posttest scores of the EG and CG. The EG demonstrated superior outcomes (p < 0.05) regarding academic engagement, emotion regulation, WTC, and academic well-being, indicating the effectiveness of incorporating Telegram alongside the LMS. Thus, this study demonstrated that utilizing the Telegram app with an LMS can significantly enhance EFL learners’ WTC, academic engagement, well-being, and emotion regulation. The findings suggest that EFL students can utilize the Telegram app to improve their English language skills outside of traditional classroom settings. Furthermore, using social media platforms like Telegram can facilitate self-study and transform the role of students. It provides EFL students with easy and rapid access to global information. The study concludes with implications, limitations, and suggestions for future research.
Assessing the impact of university students’ involvement in the first year of Nurture-U: a national student wellbeing research project
Authors: Dooley Jemima , Ghezal Amina , Gilpin Thomas , Hassan Basri Husna , Humberstone Katy , Lahdelma Amber , Misurya Pranati , Marshall Ellen , Watkins Ed 
Published: October 2023

Abstract
Background
Students experience lower levels of wellbeing than the general, age-matched population. A whole-university approach to mental health is encouraged, which must work for individuals from all backgrounds and experiences. Student input is vital in researching and designing these solutions. Nurture-U is a national, large-scale research project exploring better ways to support student wellbeing, with a Student Advisory Group (SAG) that feeds into project decision making. With the first year of the project now completed, we now critically review the processes and effectiveness of the SAG and how well the project is engaging and working with students.

Methods
Assessment of the SAG’s impact on the project, the student advisors, and the researchers was undertaken through a content analysis of team meetings and collection of advisor and researcher feedback using the Patient Engagement Quality Guidance Tool.

Results
142 students worked on different tasks in the first year of the Nurture-U project. The SAG was involved in the project branding and marketing, and in the development and co-design of interventions and tools. They reported a positive experience, with involvement boosting confidence. They felt valued but reported not always knowing whether their input was implemented in final decisions. They also recommended different methods of providing feedback. Researchers found student input beneficial to communicate the viewpoint of a different generation and increase the relevance of the study, but also suggested improvements for communication between the research team and the student group.

Conclusions
This critical reflection of the SAG’s public advisor role in this large-scale research project was important in highlighting what worked well and areas to improve. As the project unfolds, we aim to adapt our methods of student input, increase the transparency of decision-making processes, and in turn increase student-led decision making within the project.
Comparison of vertical bone resorption following various types of autologous block bone grafts
Authors: Koo Hyejin , Hwang Junghye , Choi Byung-Joon , Lee Jung-Woo , Ohe Joo-Young , Jung Junho 
Published: October 2023

Abstract
Background
This study aims to measure and compare the differences in vertical bone resorption after vertical augmentation using different types of autologous block bone.

Methods
Data were collected from 38 patients who had undergone vertical ridge augmentation using an autologous block bone before implant insertion. The patients were divided into three groups based on the donor sites: ramus bone (RB), chin bone (CB), and iliac crestal bone (IB).

Results
The surgical outcome of the augmentation was evaluated at the follow-up periods up to 60 months. In 38 patients, the mean amount of vertical bone gain was 8.36 ± 1.51 mm in the IB group, followed by the RB group (4.17 ± 1.31 mm) and the CB group (3.44 ± 1.08 mm). There is a significant difference in vertical bone resorption between the groups (p < 0.001), and the RB group demonstrated significantly lower resorption than the CB and IB groups (p = 0.011 and p < 0.001, respectively). The most common postoperative complications included neurosensory disturbance in the CB graft and gait disturbance in the IB graft. Out of the 92 implants inserted after augmentation, four implants were lost during the study period, resulting in an implant success rate of 95.65%.

Conclusions
The RB graft might be the most suitable option for vertical augmentation in terms of maintaining postoperative vertical height and reducing morbidity, although the initial gain was greater with the IB graft compared to other block bones.