bluuebunny/crossref_metadata_2025_split huggingface dataset:
The association between intolerance of uncertainty from COVID-19 and mindfulness with mental health in nursing students: A cross-sectional study
Authors: Amanat Nasir , Soleimani Mohsen , Mirmohammadkhani Majid , Jahangiri Benyamin , Khosravi Hamed 
Published: November 2023

Abstract
Aim
To examine the relationship between intolerance of uncertainty caused by COVID-19 and mindfulness with mental health in nursing students after vaccination and the reopening of universities.
Background
To control the COVID-19 pandemic, various strategies such as maintaining social distancing and lockdown were implemented in educational centers and different communities. Fluctuations caused by the change in the spread of the COVID-19 epidemic and the change in the adopted strategies made students vulnerable to stress, anxiety and maladaptive reactions and caused long-term symptoms of post-traumatic stress, confusion and anger in different groups of students.
Design:
This research was a cross-sectional correlational descriptive study that was conducted from December to March 2022 on 199 nursing undergraduate students in an online questionnaire survey in Iran.
Methods
Sampling was done based on the determined inclusion criteria. Demographic information questionnaire, general health questionnaire, intolerance of uncertainty and mindfulness questionnaire were used to collect data. The assessment tools chosen are both valid and reliable. To test the normality of quantitative variables descriptive indices were used. ANOVA and linear regression were used to analyze the data. Data analysis was done using SPSS16 software at a significance level of 0.05.
Results
The average age of the students was 21.98 ± 2.57 years. 55.8% of the participants were female and the majority of the participants (40.2%) were in the third year of their education. Most of the students suffered from the intolerance of uncertainty caused by COVID-19 and their mental health was affected, so that there was a significant and direct relationship between these two study variables. According to the demographic variables, there was a significant relationship between the score of intolerance of uncertainty and the income status of the family (P = 0.046); and with increasing income, the intolerance of uncertainty score’s decreased (r=-0.154). There was a significant and reverse relationship between intolerance of uncertainty and mindfulness, and there was a significant and reverse relationship between mindfulness and mental health score.
Conclusion
The students’ mental health was significantly affected, both those who were confident about the onset of a new wave of COVID-19 and those who were uncertain and had returned to university, compared to those who had optimistic and mindful attitudes. Mindful attention as a moderator can influence the relationship between intolerance of uncertainty and mental health.
A New Projection Neural Network for Convex Nonlinear Second-order ConeProgramming with an Application in Force Optimization Problems
Authors: Mu Xuewen , Zhao Bingcong 
Published: November 2023

Abstract

In this paper, a new projection neural network (PNN) is proposed for the convex nonlinear second-order cone programming (CNSOCP) with linear constraints. The KKT system of the CNSOCP with linear constraints is equivalent to the cone projection equations. Based on the natural residual function, a new PNN is proposed using by the descent direction of the Lyapunov function. The new PNN is derived from a projection descent direction of the prediction-correction projection and contraction method. Furthermore, the Lyapunov stability and global convergence of the proposed PNN are proved. The numerical results show the new PNN is efficient for CNSOCP problems with linear constraints and two force optimization problems.
Efficacy and safety of camrelizumab in patients with first-line and second- line therapy for esophageal squamous cell carcinoma: A multicenter, prospective, real-world study
Authors: Li Tingting , Dai Yaqing , Fu Xiaobin , Cai Qunrong , Ke Dongmei , Yao Qiwei , Li Jiancheng 
Published: November 2023

Abstract

Background In this study, we aimed to evaluate the real-world efficacy and safety of camrelizumab and identify clinicolaboratory factors that predict treatment outcomes in patients with unresectable advanced, recurrent, or metastatic esophageal squamous cell carcinoma (ESCC) receiving camrelizumab. Methods Herein, 174 patients with unresectable advanced, recurrent, or metastatic ESCC treated with camrelizumab monotherapy (n = 30), camrelizumab + chemotherapy (CT; n = 91), and camrelizumab + radiotherapy (RT; n = 53) between October 1, 2019 and October 1, 2022 were included. Results The median follow-up time was 20 months (range, 1–34 months). The median progression-free survival (PFS) and overall survival (OS) of the whole cohort were 8 months [95% confidence interval (CI), 6.5–9.5 months] and 14 months (95% CI, 11.2–16.8 months), respectively. After multivariate analysis, receiving > 4 cycles of camrelizumab and having a good lung immune prognostic index (LIPI) were identified as independent predictors of better PFS and OS. The objective response rate of patients in the camrelizumab monotherapy group, camrelizumab + CT group, and camrelizumab + RT group was 46.2%, 47.1%, and 37.3%, respectively. The treatment-related adverse events (AEs) of grade 3 or higher were reported in 67 patients (38.5%). The most common treatment-related AEs were decreased neutrophil count (23.0%), decreased white blood cell count (19.5%), anemia (7.5%), and pneumonitis (4.6%). One patient (0.6%) died from a treatment-related AE of immune checkpoint inhibitor-induced myocarditis. Conclusion Camrelizumab was safe and effective as both monotherapy and part of a combination therapy. Longer PFS and OS were associated with receiving > 4 cycles of camrelizumab and having a good LIPI. LIPI can be used as a prognostic biomarker for ESCC patients receiving camrelizumab + RT.
The association between bipolar disorder and thyroid dysfunction: a bidirectional two- sample Mendelian randomization study
Authors: Xu Yuan , You Yiting , Xu Zhilong , Ji Changle , Fang Lin 
Published: November 2023

Abstract

Background Both bipolar disorder (BD) and thyroid dysfunction contribute significantly to the global burden on the quality of life of the population. Previous studies have observed a potential association between BD and thyroid dysfunction. Our aim was to analyze the causal relationship between BD and thyroid dysfunction.Methods We ran a group of bidirectional two-sample Mendelian randomization (MR) analyses based on summary data of genome-wide association studies (GWASs) of European individuals to estimate the causal relationship between BD (N = 413,466) and thyroid dysfunction (N = 462,933). A threshold of P < 0.05 was deemed of potential evidence for a causal effect. Instrument variables (IVs) were included based on the genome-wide significance threshold (P < 5 × 10− 8) and linkage disequilibrium (LD) clumping (r2 < 0.001). In total, 41 and 39 single nucleotide polymorphisms (SNPs) from the Psychiatric Genomics Consortium (PGC) associated with BD were employed as genetic instruments for hypothyroidism and hyperthyroidism, respectively. In the reverse MR analysis, 99 and 11 variants extracted from hypothyroidism and hyperthyroidism were utilized as genetic instruments, which were obtained from recent large-scale Genome-Wide Association Studies (GWAS). Outlier assessment and sensitivity analyses of results were performed to confirm the robustness.Results Analyses suggested that BD was negatively associated with hypothyroidism (OR 0.996; 95%CI 0.993–0.999; P = 0.003). Hyperthyroidism was negatively associated with BD(OR 1.68*10− 5;95%CI 1.72*10− 7–0.002༛P = 2.52*10− 6). However, no evidence suggested an association between hypothyroidism and the risk of BD, as well as BD and the risk of hyperthyroidism.Conclusions This study provides evidence that the presence of BD is associated with a decreased risk of hypothyroidism. Meanwhile, the presence of hyperthyroidism is associated with a decreased risk of developing BD. These findings hold significant implications for future research endeavors aimed at improving treatment approaches for individuals with BD and exploring the etiology of BD.
Reduced recurrence rates with partial resection for stage III T1-2 colon cancer compared to hemicolectomy resection: a SEER database analysis
Authors: Zeng Hao , Chen Dongbo , Xue Xueyi , Zheng Biaohui , Liang Baofeng , Zhong Xuejing , Zou Pang , Xu Dongbo , Wang Xiaojie , Lin Shuangming 
Published: November 2023

Abstract
Purpose
The aim of our study was to compare the oncological survival outcomes between partial colectomy (PC) and hemicolectomy (HC) in patients diagnosed with stage III T1-2 colon cancer.
Methods
A total of 4,248 patients diagnosed with stage III T1-2 colon cancer, who underwent either hemicolectomy (n = 2,348) or partial colectomy (n = 1,900) between 2010 and 2019, were included in the Surveillance, Epidemiology, and End Results (SEER) database. We conducted a comparative analysis of overall survival (OS) and cancer-specific survival (CSS) between these two surgical groups. Additionally, we sought to determine the optimal thresholds for the number of harvested lymph nodes and tumor size. Predictive nomograms for patients with Stage III T1-2 colon cancer were constructed using independent risk factors identified CSS.
Results
The results revealed significant differences between the PC and HC groups in terms of age, gender, race, tumor site, histopathology, stage, pT, pN, scope of regional lymph nodes, postoperative chemotherapy, postoperative radiation, harvested lymph nodes, CEA pretreatment, marital status, and tumor size (all with P < 0.05). It was observed that hemicolectomy patients had slightly lower OS and CSS rates than patients who underwent partial colectomy (all with P < 0.001). Following propensity score matching (PSM), the OS and CSS rates in the two groups remained significantly different (P < 0.05). The survminer R package was employed to determine the optimal thresholds for harvested lymph node and tumor size counts in stage III T1-2 colon cancer patients, which were found to be 10 and 4.7 cm, respectively. Notably, CSS did not significantly differ between patients with ≥ 10 lymph nodes harvested and those with ≥ 12 lymph nodes harvested (P = 0.72). Univariate and multivariate Cox regression analyses, as well as survival analyses of stage III T1-2 colon cancer patients, demonstrated that patients receiving partial colectomy experienced a superior survival benefit compared to those undergoing hemicolectomy.
Conclusions
In the treatment of stage III T1-2 colon cancer patients, partial colectomy demonstrates significant oncological advantages over hemicolectomy. Harvested a minimum of 10 lymph nodes is more effective than the conventional threshold of 12 lymph nodes in distinguishing between patients with a favorable and unfavorable prognosis.
Mixed-sex clusters on grass blades –breeding strategy of the ornate dog tick, Dermacentor reticulatus
Authors: Wężyk Dagmara , Romanek Wiktoria , Małaszewicz Wiktoria , Behnke Jerzy M. , Bajer Anna 
Published: November 2023

Abstract
Introduction
Dermacentor reticulatus is second only to Ixodes ricinus in importance as a vector of infectious organisms, especially Babesia canis, the agent of canine babesiosis. The geographical range of this species, together with local densities, continue to increase in many regions of Europe. In the present study, we tested the hypothesis that D. reticulatus possesses an efficient breeding strategy allowing for a rapid increase in tick numbers and densities by formation of mixed sex clusters/aggregations, while questing in the environment.
Methods
To test this hypothesis, we carried out an observational study in spring 2023, at three sites in two regions, in Central and NE Poland, both characterised by high tick densities. At each site, a 400 metre long transect was inspected for questing ticks. All noticed ticks were collected and tick numbers and sexes per stem were recorded. Differences in tick distribution by site and sex were analysed statistically.
Results
In total 371 D. reticulatus (219 females and 152 males) were collected from 270 grass stems over a combined 1200 metres of transect. The majority of grass stems (54.2%) were occupied by just a single individual and two-tick clusters were the second most common category. Six D. reticulatus individuals were the maximum observed on only one particular grass stem.
Mixed-sex clusters were significantly more common than single-sex clusters at all three sites. With study sites combined, mixed sex clusters accounted for 17.4% (CL95=13.9-21.6%) of observations, while for multiple males and multiple females the values were 2.6 % (1.4 – 4.7%) and 5.6% (3.7 – 8.3%), respectively.
Conclusion
Mixed-sex clusters of D. reticulatus ticks were significantly more common than single-sex clusters, which we hypothesise reflects an efficient, likely pheromone-mediated, breeding strategy of this expansive tick species.
Accelerating Change in Healthcare: Leveraging Kotter's Model for a Successful Integration of Artificial Intelligence.
Authors: Alrabie Mohammad 
Published: November 2023

Abstract
Artificial intelligence in healthcare has a significant potential to deliver more efficient and effective medical services, as opposed to the current conventional practices. Although the transitioning into an artificial intelligence-based healthcare is considerably challenging, numerous cases around the world proven efficient and effective. The objective of this paper is to investigate why Kotter’s change management model is the favourable model for said change. In order to achieve that objective, a qualitative set of data has been collected and analysed. Kotter’s model has been validated based on a comparative review as well as models analysis counting in the most commonly used change management models. The paper concludes the necessity for a change management model, considering the magnitude and novelty of the change, which consequently indicates that in order to improve the delivery of medical services, by reducing cost, increasing accuracy and precision, an artificial intelligence initiative must be put in place, aided by change management. The paper also offers a framework to aid with mitigating and overcoming failures and setbacks when implementing the model.
Stigma relating to tuberculosis infection prevention and control implementation in rural health facilities in South Africa – a theoretical analysis with opportunities for mitigation
Authors: Westhuizen Helene-Mari , Ehrlich Rodney , Somdyala Ncumisa , Greenhalgh Trisha , Tonkin-Crine Sarah , Butler Chris C 
Published: November 2023

Abstract

Background
Tuberculosis (TB) is a stigmatised disease due to its associations with poverty, HIV, transmission risk and mortality. The use of visible TB infection prevention and control (IPC) measures, such as masks or isolation, can contribute to stigma.
Methods
To explore stigma in this condition, we conducted in-depth individual interviews with 18 health workers and 15 patients in the rural Eastern Cape of South Africa using a semi-structured interview guide and narrative approach. We used reflexive thematic analysis and applied Link and Phelan’s theoretical model of stigma.
Results
Participants shared poignant narratives of TB stigma, often entailing TB IPC, with some feeling ‘less than human’. We found TB IPC measures sometimes exacerbated stigma, for example through introducing physical isolation that became prolonged, or through a mask marking the person out as being ill with TB. In this context, stigma emerged from the narrow definition of what mask-wearing symbolises, in contrast with broader uses of masks as a preventative measure. In this way, the health facility itself was shown to play an important role in generating and perpetuating IPC related stigma. We applied ‘ubuntu’ as African humanist conceptual framework to develop recommendations of how TB IPC implementation could be destigmatised.
Conclusion
Health facilities may unwittingly perpetuate stigma, but they also have the potential to reduce it. Ubuntu emphases shared humanity and collective wellbeing and could engage with some of the deep-rooted contributors to TB stigma. An ubuntu-informed approach could underpin a local policy change to universal masking, thereby destigmatising an important IPC practice.
Theoretical investigation into the effect of Sulfur impurities on the electronic properties of Graphene using density functional theory
Authors: Ghafel Hussein , Salman M. K. , ahmed Ali ben 
Published: November 2023

Abstract

The electrical properties of Graphene (G.Q.D.) are studied in this research using density functional theory (DFT) by pure G.Q.D. and G.Q.D. with one S impurity, G.Q.D. with two S impurity, G.Q.D. with three S impurity graphene is intriguing because it can be adjusted electronically. We employed Graphene as a model to investigate the effect of Sulfur (S) on the electrical properties of G.Q.D. using density functional theory (DFT). Three distinct forms of S generate zinc and oxygen atoms at the ortho, meta, and para positions by changing a G.Q.D. geometry using S. A.G.Q.D. According to our findings, the presence and shape of S substantially impact the band gap values of the G.Q.D. structure. The electrical properties of the G.Q.D. are influenced not only by the amount of G.Q.D. diodes present but also by how the S diodes are arranged within the G.Q.D. We can tailor the bandgap of the G.Q.D. by appropriately doping S. These findings shed light on how chemical doping impacts the electronic characteristics of G.Q.D. and encourages the development of Nanodevices with enhanced electronic performance.
Irrigation water quality from wastewater reuse or groundwater sources: bridging the water–nutrient–food nexus
Authors: Baanu B. Bharani , Babu K. S. Jinesh 
Published: November 2023

Abstract
A field study is done to analyze the effects of water reuse for irrigation with a focus on seed germination, crop morphology, crop yield, nutritional values of edible parts, fertilizer reduction, and benefit–cost ratio. For the study, three different crops, Lablab bean, tomato, and chilli, are considered and every crop type is irrigated with groundwater (GW), diluted treated wastewater (DTWW), and treated wastewater (TWW). The study reveals that the DTWW is optimal for seed germination. Crops irrigated with the TWW have the highest morphological characteristics. Crop yield is highest for the TWW-irrigated Lablab bean and DTWW-irrigated tomato. Chilli remains unproductive until the end due to thermal stress. Nutritional values of the edible parts of the DTWW- and TWW-irrigated crops are lower than the GW-irrigated crops. Crops irrigated with the DTWW and TWW are applied with the reduced quantities of N, P and K fertilizers. Indeed, even when the dosages are low those crops are able to produce higher yields than the GW-irrigated crops which are applied with full fertilization. As the crop yield is high and fertilizer cost is less, the benefit–cost ratio is higher for water reuse irrigation than the GW irrigation.
Silencing MFHAS1 Induces Pyroptosis via the JNK-activated NF-κB/Caspase1/
GSDMD Signal Axis in Breast Cancer
Authors: Jin Yue , Zhai Mingrui , Cao Rongyi , Yu Hongmin , Wu Chunli , Liu Yanhong 
Published: November 2023

Introduction:
Breast cancer has emerged as the most widespread cancer globally surpassing lung
cancer, and has become a primary cause of mortality among women. While MFHAS1 has been implicated in
the pathophysiology of various diseases, its precise involvement in breast cancer remains unclear.

Methods:
This study endeavors to elucidate the regulatory function of MFHAS1 in breast cancer cell pyroptosis
and the associated molecular mechanisms. Our findings indicate that the inhibition of MFHAS1 can impede
the proliferation and invasion of breast cancer cells, while also inducing cell pyroptosis via caspase1-dependent
activation of GSDMD.

Results:
This process results in the cleavage of cell membranes, leading to the release of inflammatory factors
and LDH. Subsequent investigations revealed that the silencing of MFHAS1 can promote JNK phosphorylation,
thereby activating the JNK signaling cascade. Notably, this effect can be counteracted by the JNK-specific
inhibitor sp600125. Ultimately, our investigation substantiated the identical function of MFHAS1 in breast
cancer tissue derived from animal models.

Conclusion:
To summarize, our findings demonstrate that the inhibition of MFHAS1 elicits pyroptosis in human
breast cancer cells through the facilitation of JNK phosphorylation and the activation of the downstream
NF-κB/caspase-1/GSDMD signaling cascade, thereby proposing the prospect of MFHAS1 as a viable therapeutic
target for breast cancer.
Three Novel CRF01_AE/CRF07_BC Recombinant Forms of HIV-1 Identified in Shijiazhuang City, China
Authors: Lu Xinli , Ma Lin , Yan Li , Liu Meng , Wang Yingying , An Ning , Li Qi 
Published: November 2023

Background::
Hebei, a province with a low Human Immunodeficiency Virus (HIV) prevalence,
is also a region with the most abundant HIV-1 genetic diversity. HIV-1 recombinant
forms have been the key factor influencing the effectiveness of HIV-1 control and therapy.

Objectives::
We aimed to study inter-subtype recombinant structures of new HIV-1-second generation
recombinant forms.

Methods::
Monitoring the HIV-1 subtype by phylogenetic and recombinant breakpoint analyses
are the two most frequent methods among men who have sex with men (MSM). Here, three near
full-length genomes (NFLGs) were obtained from HIV-1 seropositive MSM in Shijiazhuang City,
China, who have never received antiretroviral therapy in 2021.

Results::
Phylogenetic analysis indicated that three NFLGs were novel inter-subtype recombinant
forms between CRF07_BC and CRF01_AE. For the NFLG 21S009, four CRF07_BC gene fragments
were inserted into the pol, vif-vpr, vpu-env, and nef-3` LTR gene regions within a CRF01_
AE backbone, respectively. For the NFLG 21S095, four breakpoints were identified in
HIV-1 pol and vpu regions. The NFLG 21S370 contained four gene recombinant breakpoints
within HIV-1 pol and vpu-env gene regions. Of these three NFLGs, the NFLG 21S009 contained
the most breakpoints, distributed in the pol, vif, vpr, vpu, env, and nef regions, respectively. In the
gag-pol regions, three NFLGs had only one CRF07_BC gene fragment inserted into gene points
between 4250 and 4792.

Conclusion::
Our findings provide strong evidence that the surveillance of novel recombinant
forms is necessary for the increase in better control of HIV.