bluuebunny/crossref_metadata_2025_split huggingface dataset:
Flowsheets for hydroxyacetone–phenol binary mixture separation: The use of special distillation methods
Authors: Gaganov I. S. , Rytova E. V. , Frolkova A. K. 
Published: November 2023

Objectives. To study the possibility of hydroxyacetone–phenol binary mixture (a constituent of a mixture of phenol production by the cumene method) separation in flowsheets based on the use of distillation special methods. This is the addition of separating agents to increase the relative volatility of the components of the original mixture, and the variation of pressure in the columns.Methods. A computational simulation in Aspen Plus® was used as the research method. Mathematical modeling of the vapor–liquid equilibrium was carried out using a local compositions model Non-Random Two Liquid. The viability of the latter was confirmed by comparing experimental and calculated on phase equilibrium data, and azeotropic data. The average relative error does not exceed 3%.Results. The dependence of the composition and boiling point of the hydroxyacetone–phenol azeotrope on pressure was determined in a computational experiment (as the pressure increases, the azeotrope is enriched with phenol). The possibility of using a complex of columns operating under different pressures to separate the mixture was shown (the shift of the azeotrope is about 9%). The change in the relative volatility of components of the original mixture in the presence of a high(diethylene glycol) and a low-boiling (acetone) separating agent was investigated. Both solvents are selective agents used in extractive and re-extractive distillation processes. Three technological separation flowsheets containing two distillation columns were proposed.Conclusions. The study established the operation parameters of the columns (number of theoretical stages, feed stages of the original mixture and separating agent, and reflux ratio) and energy consumption (total heat supplied to the columns boiler) of three separation flowsheets ensuring the production of products of a given quality (not less than 0.99 mol fractions). The flowsheet with diethylene glycol is characterized by the lowest energy consumption. It is recommended that complexes of extractive and re-extractive distillation be further optimized. This enables the second product of cumulus production—acetone—to be involved in the technological cycle.
Pelatihan Effurage Massage dan Aromaterapi untuk Nyeri Postpartum Pada Bidan Desa
Authors: Henniwati Henniwati , Dewita Dewita , Harahap Meliani Sukmadewi 
Published: November 2023

ABSTRAK Nyeri yang diakibatkan oleh kontraksi uterus memerlukan berbagai penanganan untuk meminimalkan rasa nyeri yang dirasakan oleh ibu sehingga kenyamanan ibu dapat kembali.Peran seorang perawat pada kondisi tersebut adalah membantu meredakan nyeri ibu post partum dengan memberikan intervensi dalam meredakan nyeri. salah satu terapi pereda nyeri adalah pijat efferuage dan aromaterapi lavender. Bidan dan kader merupakan telayanan kesehatan terdekat yang dapat dijangkau oleh pasien di desa, makadari itu perlunya peningkatan pengetahuan, pemahan dan skill untuk dapat memberikan pelayanan yang lebih baik. Kegiatan dilakukan di Wilayah Kerja Puskesmas Langsa Barat dengan jumlah sasaran sebanyak 12 orang dengan pemberian pelatihan effleurage massage dengan aromaterapi. Evaluari yang di harapkan dapat meningkatkan pengetahuan dan keterampilan peserta. Hasil dari edukasi dan pelatihan yang dilakukan didapatkan pengetahuan peserta setelah diberikan pelatihan meningkat menjadi berpengetahuan baik sebesar 83,3% dan keterampilan peserta tentang pijat effleurage setelah pelatihan sebahagian besar berketerampilan baik sebesar 83,3%. Kegiatan ini dapat disimpulkan bahwa meningkatnya pengetahuan dan keterampilan peserta tentang massage effleurage massage. Kata Kunci: Massage Efllurage, Aromaterapi, Nyeri Postpartum ABSTRACT Pain caused by uterine contractions requires various treatments to minimize the pain felt by the mother so that the mother's comfort can return. The role of a nurse in these conditions is to help relieve the pain of postpartum women by providing interventions in relieving pain. one of the pain relief therapies is efferuage massage and lavender aromatherapy. Midwives and cadres are the closest health services that can be reached by patients in the village, so it is necessary to increase knowledge, understanding and skills to be able to provide better services. Activities carried out in the Langsa Barat Health Center Working Area with a total target of 12 people by providing training in effleurage massage with aromatherapy. Evaluations are expected to increase the knowledge and skills of participants. The results of the education and training conducted obtained knowledge of participants after being given training increased to good knowledge by 83,3% and the skills of participants about effleurage massage after training were mostly good skills by 33.3%. This activity can be concluded that increasing the knowledge and skills of participants about massage effleurage massage. Keywords: Efllurage Massage, Aromatherapy, Postpartum Pain
Sosialisasi dan Pelatihan Penulisan Karya Ilmiah Bagi Guru-Guru SDI Kobelete
Authors: Baunsele Anselmus Boy , Faofeto Ambrosius , Ninu Yoaclina D. , Sooai Adri Gabriel , Nitsae Merpiseldin , Seran Lenciani 
Published: November 2023

ABSTRAK Publikasi karya ilmiah merupakan suatu syarat yang cukup penting untuk membantu memperlancar kenaikan pangkat seorang guru. Melalui kegiatan ini diharapkan para guru SDI Kobelete mampu menghasilkan karya ilmiah yang akan dipakai untuk keperluan peningkatan kariernya. Kegiatan yang akan dilakukan ini berupa sosialisasi substansi dan pelatihan penulisan karya ilmiah. Sebelum dilakukan sosialisasi maka diberikan angket kepada para peserta untuk diketahui kemampuan awal para guru. Materi yang diberikan adalah pengenalan karya ilmiah, PTK dan cara mengirimkan artikel ke jurnal. Hasil dari kegiatan PKM ini selanjutnya akan diberikan angket untuk mengetahui hasil atau perubahan yang dirasakan para guru setelah mengikuti kegiatan ini. Hasil yang diperoleh bahwa banyak indikator utama pada PKM ini yang terpenuhi diantaranya guru memahami substansi karya ilmiah, gambaran tentang PTK dan cara mengirimkan artikel ke jurnal ilmiah. Dapat dikatakan bahwa kegiatan PKM ini mampu membantu para guru untuk meningkatkan kemampuan mereka. Kata Kunci: Artikel ilmiah, PKM, Publikasi, Sosialisasi ABSTRACT Publication of scientific work is an important requirement to help facilitate the promotion of a teacher. Through this activity, it is hoped that Kobelete SDI teachers will be able to produce scientific work that will be used for career advancement purposes. The activities that will be carried out are in the form of substance socialization and training in writing scientific papers. Before the socialization was carried out, a questionnaire was given to the participants to determine the initial abilities of the teachers. The material provided is an introduction to scientific work, classroom action research, and how to submit articles to journals. The results of this community service activity will then be given a questionnaire to find out the results or changes felt by the teachers after participating in this activity. The results obtained showed that many of the main indicators of community service were met, including teachers understanding the substance of scientific work, an overview of class action research, and how to submit articles to scientific journals. It can be said that this community service activity is able to help teachers improve their abilities. Keywords: Scientific Articles, Community Service Activity, Publication, Socialization
Penerapan Pola Layer-Cake pada Tata Letak Antarmuka Pengguna Situs Berita Sepakbola
Authors: Restyandito - , Pryadi Melkhi , Raharjo Willy Sudiarto 
Published: November 2023

Dalam pengambilan keputusan, pihak pengelola situs web perlu memperhatikan bagaimana pelanggan menggunkan layanan dari situsnya. Situs "SWED sepakbola" memiliki total kunjungan 11,69 juta pengunjung. Rata-rata lama waktu kunjung adalah 1 menit 21 detik, dengan 1,54 jumlah halaman per pengunjung. Dengan jumlah bounce rate mencapai 79,17% dapat dikatakan banyaknya pengunjung pada landpage tidak memiliki jumlah interaksi yang banyak. Hal ini mengindikasikan pelanggan merasa tidak tertarik. Penelitian ini mencoba mengoptimalisasikan performa tata letak antarmuka pengguna untuk menarik interkasi pembaca dengan menekan rasio bounce menggunakan pendekatan desain layer-cake, grid dan penggunaan kolom. Perbandingan desain lama dan hasil redesain dilakukan menggunakan pengujian A/B dan perhitungan inferensial statistik. Hasilnya redesain yang dilakukan berhasil meningkatkan konversi klik, dari varian awal (varian control) ke varian yang baru (varian treatment) sebesar 40%. Konversi klik sebanyak 14 hingga 63 klik dengan pengunjung sebanyak 4 sampai 18 pengunjung dalam 4 grup yang berbeda, selama 4 kali pengujian dan pengujian tersebut, untuk menemukan nilai yang optimal hingga hasil akhir yang signifikan pada kategori “baik” dengan nilai CR “diatas rata-rata” sehingga dapat menemukan formula tata letak lebih lanjut (optimal) dari varian tata letak SWED sepakbola..
Independensi dan Kompetensi Auditor Terhadap Kualitas Audit Dengan Fee Audit Sebagai Variabel Moderasi
Authors: Fatah Yasin Eko , Muawanah Umi , Rosidi  
Published: November 2023

Abstract: The study was conducted to determine empirical evidence of audit fees as a moderating variable for the independence and competence of auditors on audit quality. This study uses a quantitative approach using explanatory research type. The population consisted of 80 auditors in the Surabaya area. The research sample was 55 auditors with a sampling technique in the form of judgment sampling. Data collection using a questionnaire. To test the feasibility of the research instrument, the validity and reliability tests were carried out. Data were analyzed using multiple linear regression. The results show that auditor independence has a significant positive effect on audit quality, auditor competence has a significant positive effect on audit quality, audit fees strengthen the effect of auditor independence on audit quality and audit fees strengthen the effect of auditor competence on audit quality. Sampling is only at the Public Accounting Firm in Surabaya.
Keywords: Independence, competence, audit quality, audit fees
Dopamine D2-receptor neurons in nucleus accumbens regulate sevoflurane anesthesia in mice
Authors: Niu Li , Hao Mengnan , Wang Yanhong , Wu Kai , Yuan Chengdong , Zhang Yu , Zhang Jie , Liang Xiaoli , Zhang Yi 
Published: November 2023

IntroductionThe mechanism of general anesthesia remains elusive. In recent years, numerous investigations have indicated that its mode of action is closely associated with the sleep-wake pathway. As a result, this study aimed to explore the involvement of dopamine D2 receptor (D2R) expressing neurons located in the nucleus accumbens (NAc), a critical nucleus governing sleep-wake regulation, in sevoflurane anesthesia.MethodsThis exploration was carried out using calcium fiber photometry and optogenetics technology, while utilizing cortical electroencephalogram (EEG), loss of righting reflex (LORR), and recovery of righting reflex (RORR) as experimental indicators.ResultsThe findings from calcium fiber photometry revealed a decrease in the activity of NAcD2R neurons during the induction phase of sevoflurane anesthesia, with subsequent recovery observed during the anesthesia’s emergence phase. Moreover, the activation of NAcD2R neurons through optogenetics technology led to a reduction in the anesthesia induction process and an extension of the arousal process in mice. Conversely, the inhibition of these neurons resulted in the opposite effect. Furthermore, the activation of NAcD2R neurons projecting into the ventral pallidum (VP) via optogenetics demonstrated a shortened induction time for mice under sevoflurane anesthesia.DiscussionIn conclusion, our research outcomes suggest that NAcD2R neurons play a promotive role in the sevoflurane general anesthesia process in mice, and their activation can reduce the induction time of anesthesia via the ventral pallidum (VP).
Assessment of geriatric and clinical domains for development and validation of a novel nomogram to predict the prognosis of older patients with breast cancer: a real-world retrospective cohort study
Authors: Lin Yan , Song Yu , Xu Ying , Wang Changjun , Xu Yali , Huang Xin , Sun Qiang 
Published: November 2023

BackgroundBreast cancer is a relatively heterogeneous disease in the older population. Survival in older breast cancer patients is not only affected by tumor-related factors, but also by geriatric assessment domains. How tumor clinical factors and geriatric factors specifically affect the survival rate of older patients and how to combine these two factors to predict the risk of death in older patients with breast cancer remain clinical questions to be addressed.MethodWe used the Peking Union Medical College Hospital database to identify older patients (≥65 years) who were newly diagnosed with breast cancer between January 2013 and December 2019. Of the 641 eligible patients, we retrospectively analyzed the clinical and geriatric data of 556 patients who formed our study population. The primary outcomes were overall survival (OS) and breast cancer-specific survival (BCSS). Univariate and multivariate Cox regression analyses were conducted to identify independent prognostic factors and construct a nomogram to predict the 1-, 3-, and 5-year survival rates. The performance of the constructed nomogram was evaluated using calibration curve, receiver operating characteristic (ROC) curve, and decision curve analysis (DCA).ResultsMultivariate Cox regression analysis revealed seven independent prognostic factors associated with OS in older patients with breast cancer: age, tumor stage, lymph node stage, intrinsic molecular subtype, functional status, comorbidities, and psychological state. Nomogram based on these seven factors yielded excellent performance, with area under the ROC curve (AUROC) of 0.748. Similarly, the nomogram for BCSS had an AUROC of 0.760. Moreover, the calibration curve and DCA revealed good predictive accuracy between the actual and predicted probabilities.ConclusionIndependent prognostic factors for OS and BCSS in older patients with breast cancer in China were determined in our study. A novel nomogram for predicting the 1-, 3-, and 5-year OS and BCSS in this patient population was developed and validated. The nomogram exhibited good accuracy, indicating its potential for clinical decision making and improving outcomes.
Immune checkpoint inhibitor-induced colitis with endoscopic evaluation in Chinese cancer patients: a single-centre retrospective study
Authors: Kou Furong , Li Jian , Cao Yanshuo , Peng Zhi , Xu Ting , Shen Lin , Gong Jifang , Wang Xicheng 
Published: November 2023

BackgroundWe investigated the clinical and endoscopic features, management strategies, and outcomes of Chinese cancer patients with immune checkpoint inhibitor (ICI)-induced colitis.MethodThis single-centre retrospective study included patients who developed ICI-induced colitis and underwent endoscopic evaluation from June 1, 2019 to October 1, 2023. We analysed clinical features, ICI-induced colitis-related information, management strategies, and outcomes.ResultsA total of 25 patients were included; most were male (88%) with a median age of 59 years. Eleven (44%) patients had grade 2 colitis, and 14 (56%) had grade 3 colitis. The median time from ICI initiation to colitis onset was 105 days. The median duration from symptom onset to endoscopic evaluation was 11 days. Regarding endoscopic evaluation, colitis involved the entire colon in 13 (52%) patients, and 15 (60%) had ulcers. Twenty-three (92%) patients received steroids, and 3 (12%) added infliximab (IFX). Most patients (n=19, 76%) achieved remission with complete tapering of the steroid taken for the first colitis episode. Among the 6 (24%) patients who did not taper initial, 5 patients increased their steroid dosage with 2 added IFX, leading to symptom remission and successful steroid tapering, while one patient experienced continuous non-remission despite increasing the steroid and receiving two infusions of IFX. Of the 8 (32%) ICI rechallenge patients, 4 achieved long-lasting benefit without colitis recurrence. The other 4 experienced recurrent colitis after ICI rechallenge and permanently discontinued ICIs. The median duration from ICI rechallenge to colitis recurrence was shorter than the time to colitis onset. One patient developed steroid-refractory colitis and recovered with one infusion of IFX.ConclusionEndoscopy has value in the evaluation and optimal management of ICI-induced colitis in Chinese cancer patients. IFX is necessary for treating colitis, especially in steroid-refractory/resistant patients. ICI rechallenge can achieve benefit, but permanently discontinuing ICIs is needed if colitis recurs. Future large-scale prospective studies are required for more accurate assessments and validation.
Comparison of Intergrowth-21st and Fenton growth standards to evaluate and predict the postnatal growth in eastern Chinese preterm infants
Authors: Lan Siyuan , Fu Huanhuan , Zhang Chengchen , Chen Yuyun , Pan Liya , Song Siqing , Wang Yizhi , Hong Li 
Published: November 2023

ObjectivesThe aim of this article was to compare the differences between Intergrowth-21st (IG-21) and Fenton growth standards in the classification of intrauterine and extrauterine growth restriction (EUGR) in eastern Chinese preterm infants, and detect which one can better relate to neonatal diseases and predict the physical growth outcomes at 3–5 years old.MethodsPremature infants admitted to a tertiary pediatric hospital in Shanghai, China, from 2016 to 2018 were enrolled. Prenatal information, neonatal diseases during hospitalization, and anthropometric data (weight, height, and head circumference) at birth and at discharge were collected and analyzed. Physical growth outcomes (short stature, thinness, and overweight) were examined by telephone investigations in 2021 at age 3–5 years.ResultsThe medium gestational age and birth weight of the included 1,065 preterm newborns were 33.6 weeks and 1,900 g, respectively. The IG-21 curves diagnosed more newborns with small for gestational age (SGA) (19% vs. 14.7%) and fewer newborns with longitudinal EUGR on height (25.5% vs. 27.9%) and head circumference (17.9% vs. 24.7%) compared to Fenton curves. Concordances between Fenton and IG-21 standards were substantial or almost perfect in the classification of SGA and longitudinal EUGR, but minor in cross-sectional EUGR. EUGR identified by Fenton curves was better related to neonatal diseases than IG-21 curves. There were no statistical significances in the prediction of short stature, thinness, and overweight at 3–5 years old between the two charts.ConclusionsIG-21 growth standards are not superior to Fenton in assessing preterm growth and development in the eastern Chinese population.
Lippia origanoides essential oil possesses anticonvulsant effect in pentylenetetrazol-induced seizures in rats: a behavioral, electroencephalographic, and electromyographic study
Authors: Bastos de Araújo Daniella , Gurgel do Amaral Anthony Lucas , Maia da Fonseca Suzane , Rodrigues de Souza Keyla , Santos da Paz Allane Patrícia , Jóia de Mello Vanessa , Barbosa Gabriela Brito , Otake Hamoy Maria Klara , Hamoy Moisés 
Published: November 2023

Epilepsy is a neuronal disorder characterized by abnormal excitability of the brain, leading to seizures. Only around 66% of the epileptic patients respond adequately to treatment with existing conventional anticonvulsants, making it necessary to investigate new antiepileptic drugs. The growing research into natural products and their pharmacological properties has become increasingly promising, particularly in the study of essential oils, which are already widely used in popular culture for treating various diseases. The present study evaluated the anticonvulsant effects of Lippia origanoides essential oil (LOEO) (100 mg/kg i. p.) compared to diazepam (DZP) (5 mg/kg i. p.), and the combined administration of these two substances to control convulsions induced by pentylenetetrazol (PTZ) (60 mg/kg i. p.). This evaluation was carried out using 108 male Wistar rats, which were divided into two experiments. Experiment 1–Behavioral assessment: The animals were divided into 4 groups (n = 9): (I) saline solution + PTZ, (II) DZP + PTZ, (III) LOEO + PTZ, (IV) LOEO + DZP + PTZ. The convulsive behavior was induced 30 min after the administration of the tested anticonvulsant drugs, and the observation period lasted 30 min. Experiment 2- Electrocorticographic evaluation: The animals were divided into 8 groups (n = 9): (I) saline solution; (II) LOEO; (III) DZP; (IV) LOEO + DZP; (V) saline + PTZ, (VI) DZP + PTZ (VII) LOEO + PTZ, (VIII) LOEO + DZP + PTZ. PTZ was administered 30 min after LOEO and DZP treatments and electrocorticographic activity was assessed for 15 min. For the control groups, electromyographic recordings were performed in the 10th intercostal space to assess respiratory rate. The results demonstrated that Lippia origanoides essential oil increased the latency time for the appearance of isolated clonic seizures without loss of the postural reflex. The animals had a more intense decrease in respiratory rate when combined with LOEO + DZP. EEG recordings showed a reduction in firing amplitude in the LOEO-treated groups. The combining treatment with diazepam resulted in increased anticonvulsant effects. Therefore, treatment with Lippia origanoides essential oil was effective in controlling seizures, and its combination with diazepam may represent a future option for the treatment of difficult-to-control seizures.
Doing housework and having regular daily routine standing out as factors associate with physical function in the older people
Authors: Li RuiQi , Dai YaLun , Han YiWen , Zhang Chi , Pang Jing , Li Jian , Zhang TieMei , Zeng Ping 
Published: November 2023

Background and objectivesNationwide data were used to explore factors associated with physical function in order to identify interventions that could improve and maintain physical function in the older people.MethodsThe physical function was assessed by gait speed (GS). We selected 2,677 male and 2,668 female older adults (aged ≥60) who could perform the GS test as study subjects. GS was measured by having subjects walk across and back a 10-m course. A gait speed less than 20% that of a reference population (&lt;0.7 m/s) was used as the definition of slow gait speed (SGS). Co-morbidity, polypharmacy, medical expenses, need for care, and hospitalization were used to evaluate health status. A stepwise logistic regression model was used to determine factors associated with SGS.ResultsSGS was associated with poorer health status, higher medical cost, lower ranking on the Geriatric Depression Scale (GDS) and decreased Mini-mental State Examination (MMSE). Co-morbidity (OR = 1.81, 1.58–2.07), polypharmacy (OR = 1.47, 1.25–1.74), MMSE &lt;24 (OR = 1.85, 1.54–2.22), and GDS ≥ 11 (OR = 1.40, 1.18–1.65) were associated with SGS. In contrast, doing housework (DHW, OR = 0.43, 0.38–0.49), having a regular daily routine (RDR, OR = 0.64, 0.45–0.91), and current alcohol consumption (OR = 0.74, 0.62–0.90) were inversely associated with SGS. DHW plus having RDR could greatly reduce the risk of SGS (OR = 0.29, 0.19–0.43).ConclusionPoor physical function is associated with poorer health status in Chinese older people. Maintaining a regular daily routine and doing some housework may be important factors that can help older people preserve their physical function.