bluuebunny/crossref_metadata_2025_split huggingface dataset:
Porosity effect on the functional properties and energy harvesting performance of Ba0.85Ca0.15Ti0.90Zr0.10O3 ceramics
Authors: Horchidan Nadejda , Curecheriu Lavinia P. , Lukacs Vlad A. , Stirbu Radu S. , Tufescu Florin M. , Dumitru Ioan , Stoian George , Ciomaga Cristina E. 
Published: December 2023

AbstractIn this study, the effect of porosity on the structural and functional (dielectric, ferroelectric, nonlinear, and piezoelectric) properties in Ba0.85Ca0.15Ti0.90Zr0.10O3 ceramics was investigated. Various levels of microporosity in the range of 3% to 31 vol.% have been produced using poly(methyl methacrylate) microspheres as sacrificial templates. The structural investigation indicates a phase coexistence, as expected for this composition at room temperature. The maximum permittivity decreases with increasing porosity, from around 7000 (ceramic with 3 vol.% porosity) down to 3500 (ceramic with 31 vol.% porosity), and the Curie temperature shifts from 47 to 67°C when increasing porosity, related to the possible porosity‐induced structural and internal stress modifications. An enhanced piezoelectric response was found in the Ba0.85Ca0.15Ti0.90Zr0.10O3 ceramic with intermediate porosity around 18 vol.%, with the highest value of piezoelectric response of 470 pC/N and a figure of merit of 7.3 pm2/N. The optimum piezoelectric properties at the intermediate porosity level are related to the microstructural changes (pore shape and connectivity) and possible field‐induced structural modifications. The piezoelectric energy harvesting measurement results have shown the possibility of using Pb‐free porous ferroelectric materials in devices for energy harvesting applications.
Insights from primary care workers supporting people at risk of suicide in local communities in Japan: A qualitative descriptive study
Authors: Tanaka Koji , Ikeuchi Satomi 
Published: December 2023

AbstractAimTo identify insights for supporting people at risk of suicide in the community based on primary healthcare workers' experiences.DesignQualitative descriptive design.MethodsSemi‐structured interviews were conducted with fifteen primary healthcare workers employed by Japanese municipalities between August and October 2019. The data were subjected to qualitative descriptive analysis.ResultsThe analysis revealed eleven subthemes, clustered under the following three themes: (1) fostering ‘opportunities for discovery’ for people at risk of suicide by encompassing strategies such as increasing access to services and promoting a holistic understanding of the life cycle; (2) fostering ‘meaningful connections’ by searching for channels to reach the heart and taking approaches from different objectives; and (3) engaging in ‘risk management’, by understanding and coping with real‐life struggles and implementing timely crisis intervention.ConclusionNot only direct care targeting suicide prevention but also holistic care that includes atypical perspectives such as ‘approaches from different objectives’ may provide important insights for supporting people with suicide risk.Implications for PracticeBeyond the limitations of existing suicide risk screening methods, this study highlights the importance of a holistic approach that sees people at risk of suicide in the context of their daily lives and aims to alleviate the difficulties in their lives that have brought them to the point of considering suicide.ImpactBy describing support focused on the difficulties that people at risk of suicide face in their daily lives, this study identified insights for supporting people at risk of suicide in communities where screening and intervention are difficult. These findings will contribute to the relief of people at risk of suicide by stimulating suicide prevention measures in primary healthcare settings.Reporting MethodThis study complied with the COREQ guidelines.Patient or Public ContributionNo patient or public contribution.
Untangling hairy cell leukaemia (HCL) variant and other HCL‐like disorders: Diagnosis and treatment
Authors: Troussard Xavier , Maitre Elsa 
Published: December 2023

AbstractThe variant form of hairy cell leukaemia (HCL‐V) is a rare disease very different from hairy cell leukaemia (HCL), which is a very well‐defined entity. The 5th WHO edition (Leukemia, 36, 2022 and 1720) classification (WHO‐HAEM5) introduced splenic lymphomas/leukaemias including four different entities: (1) HCL, (2) splenic marginal zone lymphoma (SMZL) with circulating villous cells in the peripheral blood, (3) splenic lymphoma with prominent nucleolus (SLPN), which replaced HCL‐V and CD5 negative B‐prolymphocytic leukaemia (B‐PLL), and (4) splenic diffuse red pulp lymphoma (SDRPL). All these entities have to be distinguished because of a different clinical course and the need for a different treatment. The diagnosis can be challenging because of complex cases and overlap and/or grey zones between all the entities and needs integrating clinical, histologic, immunophenotypic, cytogenetic and molecular data. We review the diagnostic criteria including clinical, immunophenotypic and molecular characteristics of patients with HCL‐V and other HCL‐like disorders including HCL, SDRPL, SMZL, B‐PLL and the Japanese form of HCL. We also discuss the different criteria allowing us to separate these different entities and we will update the recent therapeutic options that have emerged, in particular the advances with chemoimmunotherapy and/or targeted therapies.
Clinical and histopathological features in horses with neuroaxonal degeneration: 100 cases (2017‐2021)
Authors: Brown Kara A. , Bender Susan J. , Johnson Amy L. 
Published: December 2023

AbstractBackgroundAdult horses with proprioceptive ataxia and behavior changes that have histologic lesions consistent with neurodegenerative disease have been increasingly recognized.Hypothesis/ObjectivesDescribe the history, clinical findings and histopathologic features of horses presented to a referral institution with neuroaxonal degeneration.AnimalsOne hundred horses with a necropsy diagnosis of neuroaxonal degeneration compatible with neuroaxonal dystrophy/degenerative myeloencephalopathy (eNAD/EDM).MethodsRetrospective study of horses presented to the University of Pennsylvania, New Bolton Center, between 2017 and 2021 with a necropsy diagnosis of eNAD/EDM.ResultsAffected horses had a median age of 8 years (range, 1‐22), and the majority were Warmbloods (72). Sixty‐eight horses had behavioral changes, and all 100 had proprioceptive ataxia (median grade, 2/5). Fifty‐seven horses had abnormal findings on cervical vertebral radiographs, and 14 had myelographic findings consistent with compressive myelopathy. No antemortem diagnostic test results were consistently associated with necropsy diagnosis of neurodegenerative disease. All 100 horses had degenerative lesions characteristic of eNAD in the brainstem gray matter, and 24 had concurrent degenerative features of EDM in the spinal cord white matter.Conclusions and Clinical ImportanceClinical and histopathologic findings in this large group of horses with neurodegenerative disease were most consistent with eNAD/EDM, but with a different signalment and clinical presentation from earlier descriptions. The increasing occurrence of neurodegenerative disease in horses and the safety risk posed emphasize the importance of focused research in affected horses.
Adolescents' perspectives on the barriers to reading for pleasure
Authors: Webber Charlotte , Wilkinson Katherine , Duncan Lynne G. , McGeown Sarah 
Published: December 2023

AbstractAdolescence is often positioned as a particularly vulnerable period for reading motivation and engagement, both for academic reading and reading for pleasure. However, closer scrutiny of the literature reveals a much more nuanced pattern of changing interest, attitude, and motivation for reading during adolescence. Despite this, there is a distinct lack of research that explores the barriers adolescents' face to reading for pleasure from the perspectives of adolescents themselves. Working with a Young People's Advisory Panel, peer‐ and adult‐led interviews were carried out with 46 adolescents (13–15 years old) from six high schools. Six themes were identified from the thematic analysis, reflecting adolescents' perceptions of the barriers to their reading for pleasure: (1) access; (2) mismatch between provision and needs; (3) social factors; (4) reading experiences in school; (5) reading affect; and (6) time and competing activities. This article makes a novel and significant contribution to the limited literature on reading for pleasure during adolescence and provides important qualitative insights for researchers and educational practitioners interested in supporting adolescents' reading motivation.
First foods in a packaged world: Results from the COMMIT consortium to protect young child diets in Southeast Asia
Authors: Blankenship Jessica L. , White Jessica M. , Pries Alissa , Badham Jane , Betigeri Arvind , Cade Janet , Cashin Jennifer , Cosenza Lucy , Drummond Elizabeth , Mulder Anzélle , Nasser Nadine , Nguyen Tuan , Singhkumarwong Anusara , Sweet Lara , Threpleton Diane , Vu Duong , Zehner Elizabeth , Kupka Roland 
Published: December 2023

AbstractAlthough commercially produced complementary foods (CPCFs) are increasingly sold throughout Southeast Asia, concerns have been raised about CPCFs nutritional quality, labelling practices and the strength and scope of national CPCF regulations. The Consortium for Improving Complementary Foods in Southeast Asia (COMMIT), composed of UN agencies and civil society organizations, was formed to assess the nutrient gap in the diets of young children and the consumer, product and policy landscapes for CPCFs in seven Southeast Asian countries. Results from a nutrient gap assessment indicate that the diets of children aged 6–23 months are suboptimal and deficient in micronutrients. A consumer survey revealed that caretakers commonly use CPCFs, are conscious of the importance of nutrition and are influenced by label claims. Results from a CPCF benchmarking showed that many products sold in Southeast Asia contained added sugar or sweeteners, had a high total sugar and/or high sodium content and that no CPCF product adhered to all recommended labelling practices. Further, a legal review of national binding legal measures relevant to CPCFs showed minimal alignment with available global guidance. Urgent actions are necessary to strengthen national regulations related to CPCF nutrient composition and labelling practices. To speed progress, COMMIT developed a compendium of existing standards and global guidance to help countries align their national regulations with CPCF composition, labelling and production recommendations. Advocacy to garner public support for new or improved CPCF regulations, as well as strong government monitoring and enforcement of regulations, is crucial to support efforts to safeguard and improve the diets of older infants and young children in Southeast Asia.
A COMPASS histone H3K4 trimethyltransferase pentamer transactivates drought tolerance and growth/biomass production in Populus trichocarpa
Authors: Zhang Baofeng , Wang Zhuwen , Dai Xiufang , Gao Jinghui , Zhao Jinfeng , Ma Rong , Chen Yanjie , Sun Yi , Ma Hongyan , Li Shuang , Zhou Chenguang , Wang Jack P. , Li Wei 
Published: December 2023

Summary

Histone H3 lysine‐4 trimethylation (H3K4me3) activating drought‐responsive genes in plants for drought adaptation has long been established, but the underlying regulatory mechanisms are unknown.

Here, using yeast two‐hybrid, bimolecular fluorescence complementation, biochemical analyses, transient and CRISPR‐mediated transgenesis in Populus trichocarpa, we unveiled in this adaptation a regulatory interplay between chromatin regulation and gene transactivation mediated by an epigenetic determinant, a PtrSDG2‐1–PtrCOMPASS (complex proteins associated with Set1)‐like H3K4me3 complex, PtrSDG2‐1–PtrWDR5a‐1–PtrRbBP5‐1–PtrAsh2‐2 (PtrSWRA).

Under drought conditions, a transcription factor PtrAREB1‐2 interacts with PtrSWRA, forming a PtrSWRA–PtrAREB1‐2 pentamer, to recruit PtrSWRA to specific promoter elements of drought‐tolerant genes, such as PtrHox2, PtrHox46, and PtrHox52, for depositing H3K4me3 to promote and maintain activated state of such genes for tolerance. CRISPR‐edited defects in the pentamer impaired drought tolerance and elevated expression of PtrHox2, PtrHox46, or PtrHox52 improved the tolerance as well as growth in P. trichocarpa.

Our findings revealed the identity of the underlying H3K4 trimethyltransferase and its interactive arrangement with the COMPASS for catalysis specificity and efficiency. Furthermore, our study uncovered how the H3K4 trimethyltransferase–COMPASS complex is recruited to the effector genes for elevating H3K4me3 marks for improved drought tolerance and growth/biomass production in plants.
Parents' preferences for respite care of children with medical complexity
Authors: Yamamoto Yoshiko , Aoki Ai , Fuji Hiroshi , Chen Gang , Bolt Timothy , Suto Maiko , Mori Rintaro , Uchida Katsuyasu , Takehara Kenji , Gai Ruoyan 
Published: December 2023

AbstractBackgroundThe number of children with medical complexity (CMC) is increasing worldwide. For these children and their families, various forms of support are legislated; among them, short‐stay respite care has a great unmet need. We examined such children's parents' preferences for respite care and their willingness to pay.MethodsWe used discrete choice experiments (DCEs) to estimate the parents' preferences and willingness to pay. Parents whose children used overnight short‐stay respite services answered a questionnaire to compare two hypothetical facilities of respite care having seven attributes and three levels. The DCE data was analyzed using the conditional logit model. The willingness to pay was calculated based on DCE estimates.ResultsA total of 70 parents participated in this study and mean age of their children was 7.8 years (standard deviation [SD] 4.3). Among those children, 67 (96%) had the severest certification of disability, and 27 (38%) used a ventilator at home. We found that the parents' highest preferences was the best level of medical care level that can manage ventilators (coefficient 1.61, 95% confidence interval [CI]: 1.32–1.90). The better and best level of medical care, daily care, education/nursing, and emergency care were preferred over basic quality services. Willingness to pay for the best level of medical care was approximately 75,367 JPY per night.ConclusionThis study shows a need for respite care that can deliver high‐level medical care, especially for the management of ventilators, to CMC. This finding can serve as a basis for promoting respite care services.
Association between perinatal and early life exposures and lung function in Australian Indigenous young adults: The Aboriginal Birth Cohort study
Authors: Navaratnam Vidya , Forrester Douglas L. , Chang Anne B. , Dharmage Shyamali C. , Singh Gurmeet R. 
Published: December 2023

AbstractBackground and ObjectiveDespite the high burden of respiratory disease amongst Indigenous populations, prevalence data on spirometric deficits and its determinants are limited. We estimated the prevalence of abnormal spirometry in young Indigenous adults and determined its relationship with perinatal and early life factors.MethodsWe used prospectively collected data from the Australian Aboriginal Birth Cohort, a birth cohort of 686 Indigenous Australian singletons. We calculated the proportion with abnormal spirometry (z‐score <−1.64) and FEV1 below the population mean (FEV1% predicted 0 to −2SD) measured in young adulthood. We evaluated the association between perinatal and early life exposures with spirometry indices using linear regression.ResultsFifty‐nine people (39.9%, 95%CI 31.9, 48.2) had abnormal spirometry; 72 (49.3%, 95%CI 40.9, 57.7) had a FEV1 below the population mean. Pre‐school hospitalisations for respiratory infections, younger maternal age, being overweight in early childhood and being born remotely were associated with reduced FEV1 and FVC (absolute, %predicted and z‐score). The association between maternal age and FEV1 and FVC were stronger in women, as was hospitalization for respiratory infections before age 5. Being born remotely had a stronger association with reduced FEV1 and FVC in men. Participants born in a remote community were over 6 times more likely to have a FEV1 below the population mean (odds ratio [OR] 6.30, 95%CI 1.93, 20.59).ConclusionYoung Indigenous adults have a high prevalence of impaired lung function associated with several perinatal and early life factors, some of which are modifiable with feasible interventions.
Granitic‐melt and carbonic‐fluid inclusions in diopside megacrysts from ankaramitic basalt dikes at Kamisano, Yamanashi prefecture, northeastern Japan
Authors: Amagai Takashi , Kurosawa Masanori 
Published: December 2023

AbstractLarge phenocrysts, known as megacrysts, are focal points for research due to their ability to encapsulate large inclusions suitable for precise chemical analyses. Ankaramite, a distinctive type of undifferentiated volcanic rock, stands out due to its high MgO and CaO contents and the presence of abundant Ca‐rich clinopyroxene (diopside) and less common Mg‐rich olivine phenocrysts. In this study, granitic melt inclusions together with carbonic fluid inclusions were identified within diopside megacrysts of ankaramitic basalt dikes in the Kamisano region, Yamanashi Prefecture, Japan. The identified melt inclusions are completely crystallized and primarily composed of quartz, alkali feldspar, and plagioclase, with smaller amounts of pargasite, augite, apatite, and sulfides. Small amounts of residual glass were also occasionally observed in the inclusions. The average chemical composition of these granitic melts within the inclusions corresponds to that of calc‐alkaline granodiorite and the melts are characterized by low water content (0.38 wt%) and high concentrations of sulfur (7000 ppm), copper, and iron. The findings suggested that the composition of granitic melt inclusions may provide insights into the characteristics of near‐surface hydrothermal metal ore deposits. The diopside megacrysts also contain CO2H2O fluid inclusions, which are completely crystallized and mainly comprised of calcite and chlorite, along with small amounts of quartz. The crystals are interpreted to have formed by the reaction of original CO2H2O fluids and host diopside. The diopside megacrysts are estimated to have started crystallization from tholeiitic basalt at a depth of ~30 km in the lower crust, and trapped fluids and granitic melts as inclusions at a shallower depth when the tholeiitic magma ascended.
Brief video training for suicide prevention in veterans: A randomized controlled trial of VA S.A.V.E.
Authors: Teo Alan R. , Hooker Elizabeth R. , Call Aaron A. , Dobscha Steven K. , Gamble Stephanie , Cross Wendi F. , Rodgers Carie 
Published: December 2023

AbstractIntroductionVA S.A.V.E. (Signs; Ask; Validate; Encourage/Expedite) is a gatekeeper training developed by the Department of Veterans Affairs (VA) that teaches individuals to identify and assist veterans at risk for suicide. Although VA S.A.V.E. has been widely disseminated, rigorous evaluation is lacking.MethodsIn a pilot randomized controlled trial of a brief, video‐based version of VA S.A.V.E., individuals were recruited through Facebook, randomized to VA S.A.V.E. versus an attention control condition, and completed 6‐month follow‐up. A subgroup (n = 15) completed interviews. We used a mixed methods framework to integrate quantitative and qualitative findings.ResultsAmong 214 participants, 61% were spouses/partners of veterans and 77% had prior suicide exposure. Sixty‐seven percent (n = 68) of VA S.A.V.E. participants watched the entire video, and satisfaction and usability were highly rated. At 6‐month follow‐up, compared to the control group, the VA S.A.V.E. group had a higher proportion of participants use each gatekeeper behavior (66.7%–84.9% vs. 44.4%–77.1%), and used significantly more total gatekeeper behaviors (2.3 ± 0.9 vs. 1.8 ± 1.0; p = 0.01). Interviews supported positive reactions, learning, and behavior change from VA S.A.V.E.ConclusionVA S.A.V.E. merits further investigation into its effectiveness as a brief, scalable gatekeeper training for suicide prevention in veterans.
Sulbactam-durlobactam susceptibility test method development and quality control ranges for MIC and disk diffusion tests
Authors: McLeod Sarah M. , Carter Nicole M. , Huband Michael D. , Traczewski Maria M. , Bradford Patricia A. , Miller Alita A. 
Published: December 2023

ABSTRACT

Sulbactam-durlobactam is a β-lactam/β-lactamase inhibitor combination developed to treat hospital-acquired and ventilator-associated bacterial pneumonia caused by
Acinetobacter baumannii-calcoaceticus
complex (ABC). Durlobactam is a diazabicyclooctane β-lactamase inhibitor with potent activity against Ambler classes A, C, and D serine β-lactamases and restores sulbactam activity against multidrug-resistant ABC. Studies were conducted to establish sulbactam-durlobactam antimicrobial susceptibility testing methods for both broth microdilution minimal inhibitory concentration (MIC) and disk diffusion tests as well as quality control (QC) ranges. To establish the MIC test method, combinations of sulbactam and durlobactam were evaluated using a panel of genetically characterized
A. baumannii
isolates which were categorized as predicted to be susceptible or resistant based on the spectrum of β-lactamase inhibition by durlobactam. MIC testing with doubling dilutions of sulbactam with a fixed concentration of 4 µg/mL of durlobactam resulted in the greatest discrimination of the pre-defined susceptible and resistant strains. Similarly, the sulbactam/durlobactam 10/10 µg disk concentration showed the best discrimination as well as correlation with the MIC test.
A. baumannii
NCTC 13304 was selected for QC purposes because it assesses the activity of both sulbactam and durlobactam with clear endpoints. Multi-laboratory QC studies were conducted according to CLSI M23 Tier 2 criteria. A sulbactam-durlobactam broth MIC QC range of 0.5/4–2/4 µg/mL and a zone diameter QC range of 24–30 mm were determined for
A. baumannii
NCTC 13304 and have been approved by CLSI. These studies will enable clinical laboratories to perform susceptibility tests with accurate and reproducible methods.