bluuebunny/crossref_metadata_2025_split huggingface dataset:
Potential impacts of Climate change on renewable energy in Egypt
Authors: Hassaan Mahmoud Adel , Abdrabo Mohamed Abdel Karim Aly , Husseain Hadeer Hussein Ahmed , Ghanem Azza Abdallah Abdelhamid , Abdel-Latif Hany 
Published: December 2023

Abstract
The need for renewable energy sources is recently necessitated by attaining sustainability and climate change mitigation. Accordingly, the use of renewable energy sources has be growing rapidly during the last two decades. Yet, the potentials of renewable energy sources are generally influenced by a number of climatic factors that either determine the source of energy such as wind speed in the case of wind power or affect the performance of system such as the reduction in solar PV power production due to temperature increase. This highlights the need for assessing climate change impacts on renewable energy sources in the future to ensure their reliability and sustainability. This paper is intended to assess impacts of climate change on wind and solar potential energy in Egypt by the year 2065 under RCP 8.5 scenario. For this purpose, a GIs-based methodology of three main steps was applied. The results revealed that solar energy potential in Egypt is expected to be a relatively less vulnerable to climate change compared to wind energy. In this respect, it was found that while wind energy potential was estimated to range ± 12%. by the year 2065 under RCP 8.5 scenario, PV modules power is expected to decrease by about 1.3% on average. Such as assessment can assist in developing more sustainable and flexible renewable energy policy in Egypt.
Molecular Characterization of the IDUA Gene: Identification of a Haplotype associated with the p.P533R Mutation in the Maghreb Population
Authors: Chkioua Latifa , Fissi Houda El , Amri Yassine , Saheli Chayma , Bouzid Fadoua , Boudabous Hela , Tbib Neji , Ferchichi Salima , Massoud Taieb , Alif Najat , Laradi Sandrine , Abdennebi Hassen Ben 
Published: December 2023

Abstract

Background: The mucopolysaccharidosis type I (MPSI) is a lysosomal storage disease caused by a deficiency of alpha-L-iduronidase (IDUA) leading to the accumulation of partially degraded dermatan sulfate and heparan sulfate.
This 8-years this retrospective study analyzed data from42 MPSI patients.
The aim of this report was to investigate the possible origin of the p.P533R mutation in the Maghrebin population by constructing a single-nucleotide polymorphism (SNP) haplotype around the IDUA gene in order to propose a molecular proof of a founder effect of the MPSI allele.
Patients and Methods: All of the evaluated patients were Morocco (21 patients) and Tunisia (21 patients) with first cousins being the most frequent union. The diagnosis of MPSI patients often involves the combination of urine screening methods, enzyme analysis and DNA molecular analysis. In our study, we performed both sequencing and tetra-primer ARMS PCR assay to identify the common p.P533R mutation. Additionally, Haploview was used to determine the specific haplotype that cosegregates with the p.P533R mutation. Controls were genotyped to ensure that all the SNPs were in Hardy–Weinberg equilibrium.
Results: In the present report we confirmed the very strong impact of consanguinity on the expression of MPSI disease. Families of mixed ancestry shared seven common SNP haplotypes, which were observed in Moroccan and Tunisian families, thus indicating that a founder effect was present in the North African population.
Conclusion: The p.P533R missense mutation was identified in each MPSI patient originated from Morocco and Tunisia. Furthermore; the two populations exhibited the same IDUA haplotypes. These results suggest that the common haplotype may extend beyond the North African mixed ancestry population.
The regional rockfall susceptibility of road based on 267 rockfall events in Tai-Hang Mountains, China
Authors: YANG xuanyu , SUN Zhijie , WU Qijin 
Published: December 2023

Abstract
Rockfall disasters are widely developed along highways in Tai-hang Mountains. The rockfall is difficult to predict effectively because of its sudden, which brings great threat to traffic. Therefore, it is of great significance to assess the susceptibility of rockfall areas and the hazard of rockfall. The Tai-hang Mountains highways along the high and steep rock slope were regarded as the object in this paper, 267 rockfall points had been obtained through field investigation from 2020–2022. And the susceptibility of rockfall was conducted according to the topography, geomorphology, lithology, river, and structure. On this basis, the rockfall susceptibility method based on the survey data has been put forward. The tendency of rockfall along the highway in Tai-hang Mountains was conducted by this method. The research results have reference significance for the evaluation of rockfall disasters in mountainous areas, and can provide a basis for rockfall prevention.
From teeth to brain: dental caries causally affects the cortical thickness of the banks of the superior temporal sulcus
Authors: Wang Mengqiao , Wang Ziyao , Yu Yajie , Zhao Delu , Shen Zhiyuan , Wei Fulan 
Published: December 2023

Abstract
Objectives: Dental caries is one of the most prevalent oral diseases and causes of tooth loss. Cross-sectional studies observed epidemiological associations between dental caries and brain degeneration disorders, while it is unknown whether dental caries causally affect the cerebral structures. This study tested whether genetically proxied DMFS (the number of decayed, missing, and filled tooth surfaces) causally impacts the brain cortical structure using Mendelian randomization (MR).
Methods: The summary-level GWAS meta-analysis data from the GLIDE consortium were used for DMFS, including 26,792 participants. ENIGMA (Enhancing NeuroImaging Genetics through Meta Analysis) consortium GWAS summary data of 51,665 patients were used for brain structure. We estimated the causal effects of DMFS on the surface area (SA) and thickness (TH) of the global cortex and functional cortical regions accessed by magnetic resonance imaging (MRI). Inverse-variance weighted (IVW) was used as the primary estimate, the MR pleiotropy residual sum and outlier (MR-PRESSO), the MR-Egger intercept test, and leave-one-out analyses were used to examine the potential horizontal pleiotropy.
Results: Genetically proxied DMFS decreases the TH of the banks of the superior temporal sulcus (BANSSTS) with or without global weighted (weighted, β = -0.0277 mm, 95% CI: -0.0470 mm to -0.0085 mm, P = 0.0047; unweighted, β = -0.0311 mm, 95% CI: -0.0609 mm to -0.0012 mm, P = 0.0412). The causal associations were robust in various sensitivity analyses.
Conclusions: Dental caries causally decrease the cerebral cortical thickness of the BANKSSTS, a cerebral cortical region crucial for language-related functions, and is the most affected brain region in Alzheimer's disease. This investigation provides the first evidence that dental caries causally affects brain structure, proving the existence of teeth-brain axes, and suggesting the cortical thickness of BANKSSTS as a promising diagnostic measurement for dental caries-related brain degeneration.
How many and how much should be punished?: A panoptical approach in analyzing cooperation in Public Goods Games.
Authors: Botta Rocio , Blanco Gerardo , Schaerer Christian E. 
Published: December 2023

Abstract
From the harmonies that govern the behavior of an ant colony to the synchronized flight of a fleet of birds, nature eloquently demonstrates the transformative power of cooperation. It is not merely an idea but a tangible force that drives the pulse of lifeguides survival, and orchestrates the mighty symphony of evolution. Cooperation is, therefore, not a choice but a requirement— a fundamental tenet of our existence — underpinning the evolution of societies and the prevailing of nature over vast odds. Far from mere instruments of coercion, control, and punishment mechanisms are crucial safeguards in our society, nurturing cooperation and upholding justice. They discourage individuals from exploiting social frameworks and sustaining cooperation norms. In the context of a surveillance strategy designed to foster cooperation, a panoptical approach refers to a system in which control is always possible. This method creates a state of constant and deliberate visibility, which ensures that power operates automatically. It minimizes the punishment costs by making the ubiquitous impression of being watched and held accountable, encouraging cooperative conduct.
In a previous paper, we presented a punishment mechanism under panoptic surveillance in which the number of penalized individuals is reduced to an adjustable fraction of the population of free riders from which the sanctioned are randomly selected. The findings imply that by adjusting "how many" free riders are punished, potential sanctions alone can increase population-wide cooperation.
This article builds on that strategy by examining the influence of "how many" free riders are punished and analyzes the impactof "how much" the punitive sanction is severe on encouraging cooperation. We employ a compulsory public goods game model with replicator dynamics to investigate this issue. The findings suggest that long-term sustainable cooperation can be achievedby fine-tuning the compromise between retaliation severity and punishment certainty (the number of sanctioned wrongdoers),i.e., the delicate nuance of mercy and justice.
Oviposition damage and immature stages of Heilipus lauri Boheman (Coleoptera: Curculionidae) in fruits of Persea americana Miller (Lauraceae)
Authors: Rojas Jose M. , Cardona-Iral Deisy , Botero-Gómez Diana Vanessa , Jaramillo Jose Miguel , Pérez-Grajales Yuli Alejandra , Osorio-Gómez Mariana , Giraldo-Sánchez Carlos Eduardo 
Published: December 2023

Abstract

The big avocado seed weevil Heilipus lauri Boheman (Coleoptera: Curculionidae), is one of the most limiting pests for avocado exports in Latin America due to its quarantine nature. However, many aspects of its behavior and its relationship with the crop are still unknown. The infestation of an avocado backyard orchard at the Catholic University of the East in Antioquia, Colombia, and the removal of plant material allowed the collection of 66 infected fruits to collect biological data on the pest. The objective of this research was to determine the relationship between the number of perforations, the larvae found in the seeds and the morphological variables of the fruit. The results of this work suggest that a high proportion of the fruits drilled in the field have the presence of larvae of the pest, and that the weight of the fruits may influence the number of perforations carried out by the females. The instars did not show any relationship with the morphological variables of the fruits, nor with the number of perforations, which means that it is possible to find larvae of different instars regardless of the size of the fruit. These results suggest that drilling allows early detection of the pest and estimation of population densities of the immature stages in the field.
Effect of oxyfluorination of activated carbon on the adsorption of tetracycline from aqueous solutions
Authors: Min Chung Gi , Lim Chaehun , Ha Seongmin , Myeong Seongjae , Lee Young-Seak 
Published: December 2023

Abstract
Oxyfluorination treatment was used to enhance the capacity for adsorption of tetracycline (TC) from aqueous systems by activated carbon (AC). The AC was oxyfluorinated at room temperature for 5 min in a batch reactor, and the ratio of O2 and F2 gas was used as a variable. The oxyfluorination treatment increased the oxygen functional group content on the AC by up to 23.0%. The specific surface area of the oxyfluorinated AC was decreased by up to 31.7%, and the micropore volume was decreased by up to 30.6% due to strong etching by fluorine radicals. AC-O7F3 with a 23.0 at% oxygen group content showed the best TC adsorption performance because the increased number of oxygen functional groups enabled hydrogen bonding. However, the AC-O5F5 sample treated with a high fluorine partial pressure showed poor TC adsorption, which was attributed to the collapse of the pore structure and a decrease in the specific surface area due to perfluorination. Meanwhile, the TC adsorption process showed pseudosecond-order kinetics and a good fit with the Langmuir model.
A novel clinical phenotype was identified in a case of THOC6 mutant fetus
Authors: Fan Jiaqi , Sun Hairui , Jiang Huan , Zhang Siyao , Hao Xiaoyan , Xia Hongmei , He Yihua 
Published: December 2023

Abstract
Beaulieu-Boycott-Innes Syndrome (BBIS) is a rare autosomal recessive neurodevelopmental disorder genetic disorder caused by mutations in the THOC6 gene. The clinical characteristics caused by mutations in this gene and the range of variants have not yet been extensively described due to the dearth of pertinent clinical studies. Using prenatal cardiac ultrasonography, we discovered a fetus with a congenital double outlet right ventricle of the heart. The fetus as well as its parents were then subjected to a thorough genetic analysis, including whole exome sequencing, to ascertain the underlying genetic etiology. Two compound heterozygous variations for the THOC6 gene (NM_024339.5), neither of which has been reported, (exon12: c.826C>T:p.Q276* and exon3:c.178G>T:p.E60*), were identified by exome sequencing in the pre-documented individuals, and both of them received inheritances from their parents. Both of these factors affect the protein's function by changing the matching codon to a stop codon. We present a case of prenatal fetal THOC6 mutation, extending the mutation spectrum and clinical characteristics of the THOC6 gene, suggesting that the double outlet of the right ventricle of the heart may be a clinical feature caused by the mutation of the gene, and highlighting the importance of prenatal whole-exome sequencing technology in elucidating prenatal diagnosis and prognosis.
Predictors of Cocaine Use Disorder Treatment Outcomes: a Systematic Review
Authors: Palazón-Llecha Alba , Caparrós Beatriz , Trujols Joan , Duran-Sindreu Santiago , Batlle Francesca , Madre Mercè , Mallorquí-Bagué Núria 
Published: December 2023

Abstract

Background: Cocaine use disorder (CUD) is a complex condition in which multiple variables can alter the course of the addiction. Treatment retention rates with current treatment approaches are low. Thus, the aim of this study is to explore predictors of treatment retention and abstinence in CUD.
Methods: This systematic review was performed according the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA). We searched three databases—PubMed, PsychINFO and Web of Science—for randomized clinical trials published in English and Spanish from database inception through April 1, 2023. We selected all studies that met the inclusion criteria (adults aged ≥18, outpatient treatment, CUD as main addiction, and no severe mental illness) to obtain data for a narrative synthesis. After data extraction was completed, risk of bias was assessed using the Cochrane risk-of-bias tool for randomized trials (RoB-2).
Results: A total of 566 studies were screened, and, of those, 32 were included in the synthesis. Younger age, more years of cocaine use, and craving levels were significant predictors of relapse and treatment dropout. Fewer withdrawal symptoms, greater baseline abstinence, greater treatment engagement, and more self-efficacy were all predictors of longer duration of abstinence. The role of impulsivity as a predictor of CUD is unclear due to conflicting data, although the evidence generally suggests that higher impulsivity scores can predict more severe addiction and withdrawal symptoms, and earlier discontinuation of treatment.
Conclusion: The treatment of CUD is complex due to the numerous interconnected variables that can influence treatment outcomes. Consequently, it is important to identify and evaluate the factors that predict abstinence and treatment retention in order to select the most appropriate treatment approach. Finally, this study was funded by the Spanish Ministry of Science, Innovation and Universities, Instituto Carlos III (ISCIII) (FIS PI20/00929) and FEDER funds and Fundació Privada Hospital de la Santa Creu i Sant Pau (Pla d’acció social 2020).
Systematic Review registration: This systematic review is registered at PROSPERO (ID: CRD42021271847).
Effect of Body Mass Index and Blood Lipid on peak Growth Hormone Response in Children with Short Stature
Authors: Zhang Xiaohong , Yuan Gaopin , Chen Tingli 
Published: December 2023

Abstract

Aim: Short stature is a common developmental problem in children. Growth hormone deficiency (GHD) is a common type, and its diagnosis depends on growth hormone stimulation tests. However, there are few studies on the effects of body mass index (BMI) and blood lipid on the peak GH in a growth hormone stimulating test.
Methods: In this retrospective study, we enrolled 128 children with short stature between October 2018 and October 2022, analyzed the influence of BMI and blood lipid on the peak results of drug stimulation test in children with short stature.
Results: The results showed that peak GH was negatively correlated with BMI and waist circumference. IGF-1 was positively correlated with peak GH. TC, TG, HDLC and LDLC were negatively correlated with peak GH in children with short stature when LH>0.3IU/L, while IGF-BP3 was positively correlated with peak GH in children when LH<0.83IU/L. Multiple stepwise regression analysis showed that waist circumference, BMI, IGF-1, TC and TG were the influencing factors of peak GH. The growth hormone deficiency (GHD) incidence significantly increased with the elevated BMI SDS. Our study indicated that waist circumference, BMI, IGF-1, TC, and TG are the influencing factors of GH peak, and the correlation of various indicators differs with the different pubertal stages in the clonidine-insulin combined provocation test.
Conclusion: Thus, the influence of waist circumference, BMI, IGF-1, TC, TG and pubertal status should be fully considered when interpretating the provocative test results.
Graft to Vein Fistula with Partial Thrombosis: A Case Report and Literature Review
Authors: Hu Bo , Liao Zhen-Nan , Li Guo-Liang , Wan Zi-Ming 
Published: December 2023

Abstract
Hemodialysis (HD) remains the chosen treatment for patients with kidney failure. Arteriovenous fistula (AVF) remains the preferred access over arteriovenous graft (AVG), but AVG is used as crucial alternative access for patients who cannot have an AVF created. AVG complications include infection, aneurysm, thrombosis, steal syndrome, and graft to vein fistula (GVF). GVF can reduce the blood flow to the AVG, leading to frequent thrombosis. We report a case of a 62-year-old patient with end-stage renal disease (ESRD) on hemodialysis for two years, whose AVG has a functional iatrogenic fistula occasionally created by cannulation. Partial thrombosis was found in the venous limb of the AVG under sonogram analysis. We finally chose to leave GVF as an alternative HD access without further intervention after careful examination. This new vascular access, formed from GVF and the arterial limb of AVG, maintains patency for more than one year without significant complications. It may change the practice pattern of GVF in the future.
Unraveling the Causal Links and Novel Molecular Classification of Crohn’s Disease in Breast Cancer: A Two-Sample Mendelian Randomization and Transcriptome Analysis with Prognostic Modeling
Authors: Yu Xin , Yu Yushuai , Huang Xiewei , Jiang ZiRong , Wang Qing , Yu Xiaoqin , Song Chuangui 
Published: December 2023

Abstract

Background
Crohn’s disease (CD), a prominent manifestation of chronic gastrointestinal inflammation, and breast cancer (BC), seemingly disparate in the medical domain, exhibit a shared characteristic. This convergence arises from their involvement in chronic inflammation and immune responses, an aspect that has progressively captivated the attention of investigators but remain controversy.
Methods
We used two-sample Mendelian Randomization (MR) and transcriptomics to explore the relationship between CD and BC. MR assessed causality of CD on different BC subtypes and reverse causality of BC on CD. We identified CD-related differentially expressed genes and their prognostic impact on BC, and developed a new molecular BC classification based on these key genes.
Results
MR revealed a causal link between CD and increased BC risk, especially in estrogen receptor-positive (ER+) patients, but not in ER-negative (ER-) cases. BC showed no causal effect on CD. Transcriptomics pinpointed genes like B4GALNT2 and FGF19 that affected BC prognosis in CD patients. A nomogram based on these genes predicted BC outcomes with high accuracy. BC patients were reclassified into three prognostically distinct subtypes using these genes.
Conclusions
CD is a risk factor for ER + BC but not for ER- BC. BC does not causally affect CD. Our prognostic model and new BC molecular classifications offer insights for personalized treatment strategies.
Using partial resistance and a disease alert system to reduce the number of sprays to control onion downy mildew
Authors: Araújo Edivânio Rodrigues , Resende Renata 
Published: December 2023

Abstract

Downy mildew is a production limiting factor for Brazil's main onion producing region. In the present study we adopted two management strategies (resistant cultivar and disease alert system) with the aim of reducing the number of systemic fungicide sprays, maintaining satisfactory yield levels. By carrying out fungicide sprays only when the alert system indicated a severe risk and using the cultivar “SCS379 Robusta”, it was possible to reduce the number of sprays from 11 (calendar) to 5 (alert system), maintaining statistically similar yields (32.58 ton./ha – calendar; and 30.76 ton/ha – alert system). Furthermore, considering only the value of the fungicide, the production cost was BRL 0.069/Kg – calendar, and BRL 0.033/Kg – alert system. Integrated management, using different control strategies, appears to be a viable alternative to mitigate the damage caused by onion downy mildew.
Heads up for concussion, what do emergency physicians know? A scoping review
Authors: Adam Gowdy , Neil Heron 
Published: December 2023

Abstract
Introduction
Concussion is a common condition, with sources estimating between 1.2% and 6.6% of all ED presentations are related to head injury, and concussion has significant healthcare costs. In April 2023, the UK Government published guidelines for diagnosis and management of concussions in grassroots sport, recommending anyone that has sustained a suspected concussion has a same day review by an appropriate healthcare professional. It is therefore essential that emergency medicine physicians have the required knowledge and use current clinical practice guidelines in managing suspected concussions presenting to their departments. This scoping review aims to review the current literature regarding concussion knowledge, diagnosis and management amongst emergency physicians.
Material and Methods
This scoping review was conducted using the six-step process laid out by Arksey and O’Malley and included 17 papers from 2012 to February 2023, identified by searching 5 online databases (MEDLINE, Embase, Web of Science, Scopus and Google Scholar) in February 2023 alongside a hand search of references. Search terms relevant to concussion, emergency medicine and medical education were used.
Results
14 of the 17 papers originated from North America, all studies utilised either an online survey or chart review methodology. 3 papers included an educational intervention. 12 studies looked at all grades of EMPs. 14 of the studies highlighted knowledge gaps amongst EMPs, the 3 that did not specifically mention this were the 3 interventional studies.
Conclusion
EMPs have large knowledge gaps regarding concussion and limited adherence to current guidelines. Efforts should be made at improving these results amongst EMPs. Further research is needed to find the most beneficial and cost-effective approach to improving concussion knowledge of concussion diagnosis and management in EDs, particularly within the UK.