bluuebunny/crossref_metadata_2025_split huggingface dataset:
ROBOUT: a conditional outlier detection methodology for high-dimensional data
Authors: Farnè Matteo , Vouldis Angelos 
Published: September 2023

AbstractThis paper presents a methodology, called ROBOUT, to identify outliers conditional on a high-dimensional noisy information set. In particular, ROBOUT is able to identify observations with outlying conditional mean or variance when the dataset contains multivariate outliers in or besides the predictors, multi-collinearity, and a large variable dimension compared to the sample size. ROBOUT entails a pre-processing step, a preliminary robust imputation procedure that prevents anomalous instances from corrupting predictor recovery, a selection stage of the statistically relevant predictors (through cross-validated LASSO-penalized Huber loss regression), the estimation of a robust regression model based on the selected predictors (via MM regression), and a criterion to identify conditional outliers. We conduct a comprehensive simulation study in which the proposed algorithm is tested under a wide range of perturbation scenarios. The combination formed by LASSO-penalized Huber loss and MM regression turns out to be the best in terms of conditional outlier detection under the above described perturbed conditions, also compared to existing integrated methodologies like Sparse Least Trimmed Squares and Robust Least Angle Regression. Furthermore, the proposed methodology is applied to a granular supervisory banking dataset collected by the European Central Bank, in order to model the total assets of euro area banks.
Demographic characteristics influencing the stem subsidence in total hip arthroplasty: an imaging study
Authors: Migliorini Filippo , Maffulli Nicola , Pilone Marco , Velaj Erlis , Hofmann Ulf Krister , Bell Andreas 
Published: September 2023

Abstract
Introduction
The present study evaluated whether patient demographic characteristics influence the subsidence of the stem in total hip arthroplasty (THA). The following characteristics were evaluated: age, height, weight, and sex. The association between the time elapsed from the THA implantation and the amount of stem subsidence was also investigated.

Methods
The records of patients who underwent THA in the period between 2016 and 2023 were accessed. All patients underwent two-staged bilateral THA using cementless DePuy collarless Corail (DePuy Synthes, Raynham, MA, USA) stems. The following parameters were measured and compared to assess stem subsidence: distance from the proximal femur at the stem bone interface and the medial apex of the regular triangle built within the trochanter minor (point A); distance from the medial apex of the regular triangle built within the trochanter minor and the distal portion of the femoral stem (point B).

Results
Overall, 294 patients were included. 62% (182 of 294 patients) were women. 45% (134 of 296 THAs) were on the right side. The mean age was 64.9 ± 10.4 years. The mean BMI was 28.3 ± 5.1 kg/m2. The mean length of the follow-up was 14.4 ± 11.0 months. The mean subsidence in point A was 2.1 mm (P < 0.0001), and that in point B was 3.1 mm (P < 0.0001). There was evidence of a weak positive association between patient weight (P < 0.0001), age (P = 0.03), follow-up (P = 0.002) and the amount of stem subsidence. Patient height did not demonstrate any association with the amount of stem subsidence (P = 0.07). There was no difference in stem subsidence between women and men (P = 0.9).

Conclusion
Stem subsidence in THA using cementless DePuy collarless Corail implants is approximately 2.6 mm after 14.4 months. Greater patient weight, age, and longer time elapsed from THA implantation were associated with greater stem subsidence. Patient height and sex did not demonstrate any influence on the amount of stem subsidence. These results must be considered in light of the limitations of the present study.
PKC regulates αKlotho gene expression in MDCK and NRK-52E cells
Authors: Wolf Lisa , Vogt Julia , Alber Jana , Franjic Domenic , Feger Martina , Föller Michael 
Published: September 2023

AbstractParticularly expressed in the kidney, αKlotho is a transmembrane protein that acts together with bone hormone fibroblast growth factor 23 (FGF23) to regulate renal phosphate and vitamin D homeostasis. Soluble Klotho (sKL) is released from the transmembrane form and controls various cellular functions as a paracrine and endocrine factor. αKlotho deficiency accelerates aging, whereas its overexpression favors longevity. Higher αKlotho abundance confers a better prognosis in cardiovascular and renal disease owing to anti-inflammatory, antifibrotic, or antioxidant effects and tumor suppression. Serine/threonine protein kinase C (PKC) is ubiquitously expressed, affects several cellular responses, and is also implicated in heart or kidney disease as well as cancer. We explored whether PKC is a regulator of αKlotho. Experiments were performed in renal MDCK or NRK-52E cells and PKC isoform and αKlotho expression determined by qRT-PCR and Western Blotting. In both cell lines, PKC activation with phorbol ester phorbol-12-myristate-13-acetate (PMA) downregulated, while PKC inhibitor staurosporine enhanced αKlotho mRNA abundance. Further experiments with PKC inhibitor Gö6976 and RNA interference suggested that PKCγ is the major isoform for the regulation of αKlotho gene expression in the two cell lines. In conclusion, PKC is a negative regulator of αKlotho gene expression, an effect which may be relevant for the unfavorable effect of PKC on heart or kidney disease and tumorigenesis.
Differences in motor imagery abilities in active and sedentary individuals: new insights from backward-walking imagination
Authors: Mandolesi Laura , Passarello Noemi , Lucidi Fabio 
Published: September 2023

AbstractEvidence has shown that imagining a complex action, like backward-walking, helps improve the execution of the gesture. Despite this, studies in sport psychology have provided heterogeneous results on the use of motor imagery (MI) to improve performance. We aimed to fill this gap by analyzing how sport experience influences backward-walking MI processes in a sample of young women (n = 41, mean age = 21 ± 2.2) divided into Active and Sedentary. All participants were allocated to two randomized mental chronometric tasks, in which they had first to imagine and then execute forward-walking (FW) and backward-walking (BW). The Isochrony Efficiency measured the difference between imagination and execution times in both conditions (FW and BW). Moreover, we analyzed the ability to vividly imagine FW and BW within various perspectives in both groups through the Vividness of Movement Imagery Questionnaire (VMIQ-2). Findings showed that active individuals performed better in the BW imagery task when compared to sedentary ones (F1,39 = 4.98; p = 0.03*), while there were no differences between groups in the FW imagery task (F1,39 = .10; p = 0.75). Further, VMIQ-2 had evidenced that the ability to imagine backward is influenced by perspective used. Specifically, the use of internal visual imagery (IVI) led to worse Isochrony Efficiency (t32,25 = 2.16; p = 0.04*), while the use of kinesthetic imagery (KIN) led to better Isochrony Efficiency (t32,25 =  − 2.34; p = 0.03*). These results suggest a close relation between motor experience and complex motor imagery processes and open new insights for studying these mental processes.
Underweight patients experience higher inpatient complication and mortality rates following acetabular fracture
Authors: Wier Julian , Firoozabadi Reza , Duong Andrew , Patterson Joseph T. 
Published: September 2023

Abstract
Purpose
Underweight patients experience poor outcomes after elective orthopaedic procedures. The effect of underweight body mass index (BMI) on complications after acetabular fracture is not well-described. We evaluate if underweight status is associated with inpatient complications after acetabular fractures.

Methods
Adult patients (≥ 18 years) presenting with acetabular fracture between 2015 and 2019 were identified from Trauma Quality Program data. Adjusted odds (aOR) of any inpatient complication or mortality were compared between patients with underweight BMI (< 18.5 kg/m2) and normal BMI (18.5–25 kg/m2) using multivariable logistic regression and stratifying by age ≥ 65 years.

Results
The 1299 underweight patients aged ≥ 65 years compared to 11,629 normal weight patients experienced a 1.2-times and 2.7-times greater aOR of any complication (38.6% vs. 36.6%, p = 0.010) and inpatient mortality (7.9% vs. 4.2%, p < 0.001), respectively. The 1688 underweight patients aged 18–64 years compared to 24,762 normal weight patients experienced a 1.2-times and 1.5-times greater aOR of any inpatient complication (38.9% vs. 34.8%, aOR p = 0.006) and inpatient mortality (4.1% vs. 2.5%, p < 0.001), respectively.

Conclusion
Underweight adult patients with acetabular fracture are at increased risk for inpatient complications and mortality, particularly those ≥ 65 years old.

Level of Evidence
Prognostic Level III.
Excessive psychological stress preceding the onset of idiopathic cervical dystonia
Authors: Dressler Dirk , Kopp Bruno , Pan Lizhen , Adib Saberi Fereshte 
Published: September 2023

AbstractIdiopathic cervical dystonia (ICD) is the largest subgroup of dystonia. Psychological stress as a triggering factor has long been discussed, but detailed descriptions are lacking. We report on a group of 13 patients with ICD and preceding excessive psychological stress (age at ICD onset 39.0 ± 13.9 years, 7 females, 6 males). The observation period was 7.8 ± 5.0 years. Excessive psychological stress included partner conflicts (divorce and separation, domestic violence), special familial burdens, legal disputes and migration. It started 8.3 ± 3.9 months before ICD onset. In 85% of our patients (typical cases), ICD developed within 5.8 ± 4.4 weeks, then lasted 18.5 ± 8.3 months, before it started to remit 2.7 ± 0.8 years after its onset to 54.5 ± 35.3% of its maximal severity. Idiopathic dystonia is thought to be based upon a genetic predisposition triggered by epigenetic factors. Our study suggests that excessive psychological stress could be one of them. Pathophysiologic elements are only vaguely identified, but could include the endoplasmic reticulum stress response, cerebellar 5HT-2A receptors and the metabolism of heat shock proteins. Whilst the clinical presentation of ICD preceded by excessive psychological stress is typical, its course is atypical with rapid onset and fast and substantial remission.
Pocket closure after repeated subgingival instrumentation: a stress test to the EFP guideline for stage III-IV periodontitis
Authors: Ferrarotti Francesco , Baima Giacomo , Rendinelli Martina , Citterio Filippo , Mariani Giulia Maria , Mussano Federico , Romano Federica , Romandini Mario , Aimetti Mario 
Published: September 2023

Abstract
Objectives
To study the effects of one or two repeated subgingival instrumentations (RSI) in achieving the endpoints of therapy (EoT) in open pockets [residual probing pocket depth (PPD) ≥ 6 mm and PPD 4–5 mm with bleeding on probing (BoP)] after steps I-II of therapy.

Materials and methods
Twenty-five patients (3,552 total sites; 1,450 open pockets) with stage III-IV periodontitis received steps I-II of periodontal therapy and were re-evaluated after 4–6 weeks (T1). Residual pockets received RSI at T1 and at 3 months (T2). EoT (PPD < 4 or PPD < 6 BoP-) rate at T1, T2 and 6 months (T3) was computed. The number of needed surgeries and treatment costs were calculated.

Results
At T1, 67.6% of open pockets achieved EoT. At residual PPD ≥ 6 mm at T1 (n = 172), one and two RSI resulted in 33.1% and 45.9% of EoT at T2 and T3, respectively. At residual PPD 4–5 mm with BoP at T1 (n = 298), one and two RSI resulted in 66.8% and 72.1% of EoT at T2 and T3, respectively. PPD at T1 predicted EoT after RSI in both cases, while tooth type only in residual PPD 4–5 mm BoP + . At T1, mean number of surgeries per patient and associated costs were significantly higher than after one/two RSI.

Conclusions
RSI may achieve EoT in residual PPD 4–5 mm BoP + and PPD ≥ 6 mm in a considerable number of cases.

Clinical relevance
These findings may support the administration of one/two cycles of RSI prior to surgical approach.

Protocol registration
ClinicalTrials.gov identification number: NCT04826926.
Being a long distance out-commuter or home employee in a rather peripheral region evidence of a German federal state
Authors: Brunow Stephan , Jost Ramona 
Published: September 2023

AbstractMany firms in Germany are short of qualified workers, whereby East German regions are particularly affected because of the out-migration to West Germany after the reunification. This gives rise to an important debate for regional policy as the shortage of workers is a major challenge for each region and firm. In this context, out-commuters—workers who commute to work in another region—become an important group of employees to potentially satisfy local labour needs. In this study, we take a closer look at out-commuters in a particular eastern German region—the Federal State Mecklenburg-Vorpommern (MV)—and address the question whether out-commuters are a selective group of individuals working in e.g. occupations or industries that are rarely needed for labour market requirements in MV. Further, we focus on the wage differential between out-commuters and workers who are living and working in MV (home employees). The determination of the factors that explain this wage gap can provide new insights and a deeper understanding of the labour market in MV. This can provide a basis to work out potential strategies to attract the group of out-commuters for a workplace in MV to reduce the complained labour shortage. The derived evidence suggests that only few out-commuters can be recalled, as the labour demand in MV and the respective wage level are too low and the economic structure is too weak to sufficiently gain back out-commuters. Especially females suffer from the job-market weakness in MV.
Contribution of the wind, Loop Current Eddies, and topography to the circulation in the southern Gulf of Mexico
Authors: Olvera-Prado Erick R. , Romero-Centeno Rosario , Zavala-Hidalgo Jorge , Moreles Efraín , Ruiz-Angulo Angel 
Published: September 2023

AbstractThe Bay of Campeche, located in the southern Gulf of Mexico (GoM), is characterized by a semi-permanent cyclonic circulation commonly referred to as the Campeche Gyre (CG). Several studies documenting its upper layer structure have suggested a possible relationship between its seasonal variability and the wind stress, and that non-seasonal variability arises mainly from the interaction of the gyre with Loop Current Eddies (LCEs) that arrive in the region. Nevertheless, a partition of the contributions of these forcings to the circulation of the CG in a statistically consistent manner is still needed. This study examines the wind- and eddy-driven circulation with long-term numerical simulations of the GoM using the HYbrid Coordinate Ocean Model. Our results show that, in the absence of LCEs, the wind can sustain a seasonal-modulated circulation in the CG, confined within the upper 600 m. When considering LCEs, high fluctuations on the flow at intraseasonal time scales are imposed. We found that the LCEs influence the western Bay of Campeche circulation through two main mechanisms: (a) by decelerating and inhibiting the CG through a positive vorticity flux out of the bay, leading to reversals in the flow if LCE southward penetration is large, or (b) by strengthening the CG when a big cyclone, accompanying the LCE, enters the region. It is proposed that the second mechanism is responsible for inducing a net weak cyclonic circulation in the Bay in the absence of wind. Furthermore, past studies have shown that the CG behaves as an equivalent-barotropic flow, with topography acting to confine the CG to the west of the bay. In our modeling results, the role of topography manifests similarly among the different numerical experiments, resulting in closed geostrophic contours to the west of the bay that confine an upper-layer, nearly-symmetric, equivalent-barotropic CG.
Gentle Algebras Arising from Surfaces with Orbifold Points of Order 3, Part I: Scattering Diagrams
Authors: Labardini-Fragoso Daniel , Mou Lang 
Published: September 2023

AbstractTo each triangulation of any surface with marked points on the boundary and orbifold points of order three, we associate a quiver (with loops) with potential whose Jacobian algebra is finite dimensional and gentle. We study the stability scattering diagrams of such gentle algebras and use them to prove that the Caldero–Chapoton map defines a bijection between $$\tau $$
τ
-rigid pairs and cluster monomials of the generalized cluster algebra associated to the surface by Chekhov and Shapiro.
Correlation between breast cancer subtypes determined by immunohistochemistry and n-COUNTER PAM50 assay: a real-world study
Authors: Lopez-Tarruella Sara , Del Monte-Millán María , Roche-Molina Marta , Jerez Yolanda , Echavarria Diaz-Guardamino Isabel , Herrero López Blanca , Gamez Casado Salvador , Marquez-Rodas Iván , Alvarez Enrique , Cebollero María , Massarrah Tatiana , Ocaña Inmaculada , Arias Ainhoa , García-Sáenz José Ángel , Moreno Anton Fernando , Olier Garate Clara , Moreno Muñoz Diana , Marrupe David , Lara Álvarez Miguel Ángel , Enrech Santos , Bueno Muiño Coralia , Martín Miguel 
Published: September 2023

Abstract
Purpose
Molecular subtyping based on gene expression profiling (i.e., PAM50 assay) aids in determining the prognosis and treatment of breast cancer (BC), particularly in hormone receptor (HR)-positive/human epidermal growth factor receptor 2 (HER2)-negative tumors, where luminal A and B subtypes have different prognoses and treatments. Several surrogate classifications have been proposed for distinguishing between the luminal A and B subtypes. This study determines the accuracy of local immunohistochemistry (IHC) techniques for classifying HR-positive/HER2-negative (HR+/HER2−) tumors according to intrinsic subtypes using the nCOUNTER PAM50 assay as reference and the HR status definition according the ASCO/CAP recommendations.

Methods
Molecular subtypes resulting from nCOUNTER PAM50 performed in our laboratory between 2014 and 2020 were correlated with three different proxy surrogates proposed in the literature based on ER, PR, HER2, and Ki67 expression with different cut-off values. Concordance was measured using the level of agreement and kappa statistics.

Results
From 1049 samples with the nCOUNTER test, 679 and 350 were luminal A and B subtypes, respectively. Only a poor-to-fair correlation was observed between the three proxy surrogates and real genomic subtypes as determined by nCOUNTER PAM50. Moreover, 5–11% and 18–36% of the nCOUNTER PAM50 luminal B and A tumors were classified as luminal A and B, respectively, by these surrogates.

Conclusion
The concordance between luminal subtypes determined by three different IHC-based classifiers and the nCOUNTER PAM50 assay was suboptimal. Thus, a significant proportion of luminal A and B tumors as determined by the surrogate classifiers could be undertreated or over-treated.
Association of triglyceride glucose index levels ​​with calcification patterns and vulnerability of plaques: an intravascular ultrasound study
Authors: Yin Da , Wang Minxian , Liu Xuesong , Pan Weili , Ren Yongkui , Liu Jinqiu 
Published: September 2023

AbstractPurpose: High triglyceride glucose (TyG) index level is one of the risks for cardiovascular events. The purpose of this research was to examine the correlation of the triglyceride glucose (TyG) index levels with plaque characteristics and calcification types determined by intravascular ultrasound (IVUS) in acute coronary syndrome (ACS) patients. Methods: A total of 234 acute coronary syndromes (ACS) participants who completed intravascular ultrasound (IVUS) and coronary angiography (CAG) were finally enrolled. Results: Logistic regression analysis manifested that the TyG index was independently correlated with the occurrence of coronary calcification, minimum lumen area (MLA) ≤ 4.0 mm², plaque burden (PB) > 70%, and spotty calcification. Taking the lowest group as a reference, the risk of coronary calcification (OR, 2.57; 95%CI, 1.04–6.35; p = 0.040), MLA ≤ 4.0 mm² (OR, 7.32; 95%CI, 2.67–20.01; p < 0.001), PB > 70% (OR, 2.68; 95%CI, 1.04–6.91; p = 0.041), and spotty calcification (OR, 1.48; 95%CI, 0.59–3.71; p = 0.407) was higher in the highest TyG index group. TyG index was converted into a dichotomous variable or a continuous variable for analysis, and we found that a similar result was observed. In addition, optimal predictive models consisting of clinical variables and the TyG index distinctly improved the ability to predict the prevalence of coronary calcification and MLA ≤ 4.0 mm² (p < 0.05). Conclusion: The TyG index may serve as a potential predictor for calcification patterns and plaque vulnerability.
Experimental Study of Development of Fracture Process Zone in Rock
Authors: Qiao Yang , Zhang Zong-Xian , Zhang Sheng 
Published: September 2023

AbstractBy means of digital image correlation (DIC) technology, the displacements and strains on the fracture ligaments of rock specimens were measured during loading. By analyzing the displacement distribution of each fracture ligament at different loading stages, the displacement fluctuation coefficient method was proposed to describe the development of fracture process zone (FPZ). The method can amplify the variation of displacement and clearly show the length of FPZ.The results show that: (1) the initiation of FPZ occurred at 77–89% of the peak load and the fluctuation coefficient of horizontal displacement around the crack tip reached the order of 10–7. (2) The initial length of FPZ was about 1.0–3.1 mm, which is 2 to 6 times the largest grain sizes. As the peak load was approached, the length of FPZ suddenly increased to 4.6–6.1 mm. (3) When a fracture process zone was initiated, the strain at the front end of the FPZ was about 3000–4000 µε. After the load approached the peak value, the strain at the rear end of the FPZ finally reached a peak value of 8000–11000 µε in all specimens.
Effects of Body Mass and Age on the Pharmacokinetics of Subcutaneous or Hyaluronidase-facilitated Subcutaneous Immunoglobulin G in Primary Immunodeficiency Diseases
Authors: Li Zhaoyang , Follman Kristin , Freshwater Ed , Engler Frank , Yel Leman 
Published: September 2023

Abstract
Purpose
To assess the pharmacokinetics (PK) of subcutaneous immunoglobulin (SCIG) and hyaluronidase-facilitated SCIG (fSCIG) therapy across body mass index (BMI) and age categories in patients with primary immunodeficiency diseases (PIDD) previously treated with intravenous immunoglobulin (IVIG).

Methods
Using our previously published integrated population PK model based on data from eight clinical trials, simulations were conducted to examine the effects of BMI and age on serum immunoglobulin G (IgG) PK after administration of SCIG 0.15 g/kg weekly or fSCIG 0.6 g/kg every 4 weeks in patients switching from stable IVIG. Patients were assumed to have baseline IgG trough concentrations of 7 g/L (hypothetical protective threshold).

Results
Mean steady-state serum IgG trough values (Cmin,ss or trough) increased with BMI and age. Mean Cmin,ss was 18% (SCIG) and 16% (fSCIG) higher in the obese than the healthy BMI group. Pediatric patients aged < 18 years had 8–22% (SCIG) and 4–20% (fSCIG) lower mean Cmin,ss values than adults, with the youngest group (2– < 6 years) having the lowest Cmin,ss. All patients across populations maintained Cmin,ss IgG concentrations of ≥ 7 g/L after switching to SCIG or fSCIG.

Conclusion
Both SCIG and fSCIG successfully maintained trough values at or above the hypothetical protective threshold after switching from stable IVIG, irrespective of BMI or age. Differences in trough values between BMI groups and age groups (≤ 22%) may not warrant SCIG or fSCIG dose adjustments based on BMI or age alone; instead, the dosing paradigm should be guided by prior IVIG dose, individual IgG monitoring, and clinical findings.