bluuebunny/crossref_metadata_2025_split huggingface dataset:
Application of a fan type screw to improve the aesthetics of the dentition in the anterior maxilla – a case report
Authors: Aksamit Jolanta , Matthews‑Brzozowska Teresa 
Published: November 2023

Narrowing of the upper dental arch is one of the most common problems encountered by orthodontists in their practice. This abnormality often affects only the anterior part of the maxilla, while the lateral regions maintain the proper width. The reduced width of the dental arch results in insufficient space for the correct alignment of all teeth, leading to crowding and rotation, which significantly deteriorates the aesthetics of the smile. This paper presents a case of a patient who was found to have hypertonicity of the mental muscle during the extraoral examination, and intraoral examination revealed narrowing of the upper dental arch in the anterior segment and crowding of the upper incisors with a deficit of space for the canines. After the orthodontic diagnostic process was performed, a fan‑type expander was used as the initial treatment. With one daily activation, the desired effect of increasing the anterior maxilla width was achieved after 18 days, and a satisfactory correction of the smile was achieved after 18 months.
Social Networks, the COVID-19 Pandemic, and Emerging Adults’ Mental Health: Resiliency Through Social Bonding and Cohesion
Authors: Perry Brea L. , Smith Nicholas C. , Coleman Max E. , Pescosolido Bernice A. 
Published: November 2023

Objectives. To assess how personal social network characteristics moderated mental health declines during the COVID-19 pandemic in emerging adults compared with other age groups. Methods. The Person to Person Health Interview Study, a representative, probability-based cohort study (n = 2485) in Indiana, collected data through face-to-face (baseline) and phone (follow-up) interviews before and during the pandemic. We used survey-weighted growth curve models to examine network effects on computer-adaptive testing measures of depression and anxiety severity. Results. Respondents reported significantly increased depression and anxiety in 2021, which returned almost to baseline levels for most age groups by 2022 ( P < .001). Stronger ties to others and more interconnected ties were significantly associated with lower depression (B = −0.112 [ P < .05]; B = −0.086 [ P < .001]) and anxiety (B = −0.101 [ P < .05]; B = −0.063 [ P < .01]) severity across the pandemic. Interaction models revealed disproportionate protective effects of network characteristics on depression (B = −0.456 [ P < .001]; B = −0.268 [ P < .001]) and anxiety (B = −0.388 [ P < .001]; B = −0.284 [ P < .001]) for emerging adults. Conclusions. Cohesive and affectively strong personal networks promote resiliency to common mental health challenges during periods of crisis, particularly for emerging adults whose social roles and relationships were disrupted during a critical period of development. ( Am J Public Health. 2024;114(S3):S258–S267. https://doi.org/10.2105/AJPH.2023.307426 )
The impact of comorbidities on outcomes in the multiple sclerosis population: a rapid review protocol
Authors: Frank Hanna A , Chao Melissa , Tremlett Helen , Marrie Ruth Ann , Lix Lisa M. , Karim Mohammad Ehsanul 
Published: November 2023

Abstract
Introduction: People with multiple sclerosis (MS) experience higher comorbidity burden than the non-MS population. Research has shown that having comorbidities alongside MS can lead to worse MS outcomes, including faster rates of disability progression, delays in initiating disease-modifying treatments, and earlier death. A comprehensive overview of which comorbidities affect these outcomes has not yet been published. This review aims to summarize what is currently known about these relationships to inform the development of a comorbidity index specific to people with MS.
Methods and analysis: A rapid review structure will be implemented that is in line with the current recommendations by the Cochrane Rapid Review Methods Group. Two databases will be searched (MEDLINE and EMBASE) and a grey literature search will be included. The Newcastle-Ottawa scale will be used for a risk of bias assessment. Results will be displayed visually in tables and graphs, as well as through a narrative synthesis.
Ethics and dissemination: Ethics approval is not required for this review. The rapid review will be submitted for publication in peer-reviewed journals. The results will also be disseminated through conferences and seminars.
PROSPERO registration number: CRD42023475565
Degradation of cetirizine by integrated techniques involving ozone and biological treatment process
Authors: Sarkhel Rwiddhi , Sarkar Kalyan Kumar , Chatterjee Pradip Kumar , Gupta Parthapratim , Mandal Tamal 
Published: November 2023

Abstract
Nowadays, wastewater treatment has been a major concern for organic contaminants which create hazardous effects on human health and the environment. In India, there are several pharmaceutical manufacturing industries located across the states from north to south and east to western states. These industries generate a lot of toxic effluent that is produced and disposed of into the ground, especially in open ground or surface water. So, here removal of pharmaceutical waste is chosen for the present focus of study. Cetirizine is an intense second-generation histamine H1 antagonist that compels in the treatment of allergic susceptible rhinitis and asthma. Therefore, eradication of cetirizine by integrated treatment serves to be an appealing option for the researchers. The degradation of pharmaceutical waste has been studied by the integrated treatment comprising Ozonation, and biological treatment by E. aurentiacum KX008295.1. The integrated treatment removes about 60% of cetirizine which tells that it is an effective option to treat types of pharmaceutical waste.
Construction of self-driving anti-αFR CAR-engineered NK cells based on IFN-γ and TNF-α synergistically induced high expression of CXCL10
Authors: Yi Ping , He Min 
Published: November 2023

Abstract
Background: Ovarian cancer is one of the most common gynecological malignancies. Previous studies have demonstrated that chimeric antigen receptor (CAR)-engineered NK-92 cells targeting folate receptor α (αFR) (NK-92-αFR-CAR) can specifically kill αFR-positive ovarian cancer cells, and are therefore a promising therapeutic approach for ovarian cancer. However, the migration barrier of CAR-engineered immune cells significantly restricts their antitumor effects. In addition, few studies have focused on biological changes in tumor cells other than death during the antitumor process of CAR-engineered immune cells.
Methods and Results: In this study, RNA sequencing (RNA-seq) first revealed that the expression level of the chemokine CXCL10 was most significantly increased in ovarian cancer cells co-cultured with NK-92-αFR-CAR. Second, cytokine stimulation and specific antibody neutralization experiments were used to confirm that IFN-γ and TNF-α secreted by NK-92-αFR-CAR synergistically induced high CXCL10 expression in ovarian cancer cells. Further signaling pathway inhibition, small interfering RNA (siRNA) interference, and luciferase reporter assays showed that IFN-γ induced ovarian cancer cells to express CXCL10 via the JAK1/2-STAT1 pathway, while the TNF-α-activated NF-κB pathway not only mediated the transcription of CXCL10, but also upregulated the expression of IFN-γ receptor 1 (IFNGR1), which further enhanced the activation level of the IFN-γ-IFNGR-JAK1/2-STAT1-CXCL10 signaling axis. Finally, anti-αFR CAR (αFR-CAR) and CXC-chemokine receptor 3A (CXCR3A), the CXCL10 receptor, were highly co-expressed in NK-92 cells (NK-92-αFR-CAR-CXCR3A) following lentivirus gene transfection. Cytotoxicity lactate dehydrogenase (LDH) assay and enzyme-linked immunosorbent assay (ELISA) showed that NK-92-αFR-CAR-CXCR3A could not only efficiently kill αFR-positive ovarian cancer cells in vitro but also secrete IFN-γ and TNF-α, which induced high expression of CXCL10 in tumor cells. Higher migration than that of NK-92-αFR-CAR was detected in NK-92-αFR-CAR-CXCR3A cells using a transwell assay. Compared with NK-92-αFR-CAR, NK-92-αFR-CAR-CXCR3A effectively killed tumor cells in different mouse xenograft models of ovarian cancer and significantly prolonged the survival time of tumor-bearing mice. Increased infiltration of NK-92-αFR-CAR-CXCR3A into tumor tissue was observed using immunohistochemistry.
Conclusions: This study not only confirmed that IFN-γ and TNF-α secreted by αFR-CAR-engineered NK cells can synergistically induce high expression of CXCL10 in ovarian cancer cells but also constructed self-driving αFR-CAR-engineered NK cells that can break through migration barriers based on the chemotaxis of CXCL10, which may provide a new powerful therapeutic weapon for ovarian cancer.
Screening Performance of COPD-PS Scale, COPD-SQ Scale, Peak Expiratory Flow, and Their Combinations for Chronic Obstructive Pulmonary Disease in the Primary Healthcare in Haicang District, Xiamen City
Authors: Pan Zhigang , Shen Xueting , Yang Hua , Lan Chengdian , Tang Fen , Lin Qinfei , Chen Yingjie , Wu Jinxiang , Chen Xionghua 
Published: November 2023

Abstract

Chronic Obstructive Pulmonary Disease (COPD) is a common chronic disease, and its screening performance is crucial for improving early diagnosis and treatment. Our study aims to evaluate the screening performance of COPD-PS questionnaire, COPD-SQ questionnaire, Peak Expiratory Flow (PEF), COPD-PS questionnaire combined with PEF, and COPD-SQ questionnaire combined with PEF for COPD. We collected data from February 2023 to May 2023, distributing self-designed general information survey forms and COPD screening scales (COPD-PS questionnaire and COPD-SQ questionnaire) to residents undergoing physical examination in five community health service centers in Haicang District, Xiamen City, and completed lung function tests and PEF using a portable lung function detector. The results showed that the sensitivity of diagnosing COPD by COPD-SQ questionnaire, COPD-PS questionnaire, PEF, COPD-PS questionnaire combined with PEF, and COPD-SQ questionnaire combined with PEF were 0.439, 0.586, 0.519, 0.586, 0.612 respectively, and the specificity were 0.725, 0.621, 0.688, 0.689, 0.663 respectively, with ROC values of 0.606 (95%CI: 0.586–0.626), 0.640 (0.619–0.661), 0.641 (0.619–0.663), 0.678 (0.657–0.699), 0.685 (0.664–0.706) respectively. The sensitivity of diagnosing GOLD II and above by COPD-SQ questionnaire, COPD-PS questionnaire, PEF, COPD-PS questionnaire combined with PEF, and COPD-SQ questionnaire combined with PEF were 0.489, 0.620, 0.665, 0.630, 0.781 respectively, and the specificity were 0.714, 0.603, 0.700, 0.811, 0.629 respectively, with ROC values of 0.631 (95%CI: 0.606–0.655), 0.653 (0.626–0.679), 0.753 (0.730–0.777), 0.784 (0.762–0.806), 0.766 (0.744–0.789) respectively. Our study found that the accuracy of COPD screening by COPD-SQ questionnaire and COPD-PS questionnaire can be improved by combining the results of PEF. The screening performance of COPD-SQ questionnaire combined with PEF is relatively better. In future research, further studies are needed to optimize the performance of screening tools and understand whether their use will affect clinical outcomes.
Input interactions and Structural Dynamics in Greek agriculture productivity
Authors: Mandanas Zisis C. , Petropoulos Dimitrios P. 
Published: November 2023

Abstract
This paper aims to analyze the impact of fixed capital, variable inputs and labor and their interaction to the volume of the agricultural output in Greece, for the period 1981 - 2021, using the estimation equation of a Cobb-Douglas equation form. At a second level, an attempt is made to investigate possible changes in this relationship over time, using the Bai-Perron structural changes method and their effect on the observed relationship between agricultural inputs and output. The existence of a structural break in 2006 was confirmed, which is accompanied by differences in elasticities before and after this year. During the period 1981-2005, positive elasticities of labor and fixed capital were observed, indicating that the increase in these factors contributed positively to agricultural production, but with decreased returns to scale. In contrast, after 2006, negative elasticity of labor and fixed capital was detected, while the elasticity of variable factors of production remained positive. This change in elasticities indicates the inefficiency in the use of fixed capital and labor after 2006 and the increased influence of variable production factors on agricultural production. These findings highlight the need for continuous monitoring and analysis of factors affecting agricultural production, in order to enhance the competitiveness of the corresponding sector and ensure its sustainability in the future, offering new perspectives for the design and implementation of policies that will enhance agricultural development.
JEL classification: O130, Q100, R150
The Influence of Climate Change on Flooding and Social Inequalities from Remnants of Hurricane Ida
Authors: Li Xue , Wehner Michael , Judi David , Hetland Robert 
Published: November 2023

Abstract
Previous research has demonstrated that tropical cyclone-related precipitation and flooding have been increased by anthropogenic global warming. Our work aims to quantify the contribution of climate change to the deadly flooding from the remnants of Hurricane Ida (2021) and its impact on human society. We developed an analysis framework that combines lessons from climate change attribution science, two-dimensional hydrodynamic modeling, and flood impact evaluation, including a social inequality index, to estimate remnants of Ida flooding and consequences responding to current (locally 1° C warmer) and future (another 1° C warmer) climate change. We find that an additional quarter to a half million people were exposed to flooding due to current and future climate change. The human influence on flood impacts was larger with deeper flood depth (≥ 1 m) than with shallow depths. Socially vulnerable populations were found to be disproportionately more affected, and climate change exacerbates this inequality.
Idiopathic Harlequin Syndrome: A case report and literature review
Authors: MNAILI MOHAMED AMINE , Bourazza Ahmed 
Published: November 2023

Abstract
Harlequin's syndrome is a rare dysautonomic syndrome of the face characterized by sweating with flush of one side and anhidrosis of the contralateral side. Mostly idiopathic although several secondary cases have been reported in the literature, the purpose of the treatment is mainly aesthetic and functional. We report the case of a patient having harlequin syndrome in its idiopathic form with a literature review.
The Factors and Actors Engaged in Land Transaction Arrangement and Commoditization in Africa: an Example From the Bolgatanga Municipality of Northern Ghana
Authors: Akolgo-Azupogo Helen , Bardy Roland , Soale Joseph M. 
Published: November 2023

Abstract
Increase in multiple demands for land in Africa has been affected by increased global food and energy requirements together with population growth. This has in turn led to large-scale acquisition of lands for agriculture by foreigners and wealthy local investors. Small holder farmers are at risk of losing their lands to the investors even if they receive government support. What the African indigenous tradition has seen to be a gift of God to man is now commoditized. This often marginalizes the local people, undermines their livelihood. Information on the factors and actors in land commoditization is inadequate and often withheld. The paper sets out to identify these actors and factors. The Bolga Municipality is used as an example because the area carries all the characteristics that can be found throughout most of Africa. Data was gathered using key informant interviews, focus discussion and secondary sources.
The findings of the study reveal the following factors which urge people to sell their lands:
The need to pay school fees, people’s desire to build and live in decent houses, the need to expense money to uphold the tradition of resplendently celebrating funerals or to raise funds for the dowry of a bride, the fact that owners of small land parcels are often unemployed.
To solve the issues better information on the issue is needed as well as purposeful job-creation to decrease unemployment and socially adequate mortgages.
If the government does not take up the problem, social cohesion will fall apart.
Iodine-based dual-energy CT predicts early neurological decline from cerebral edema after large hemispheric infarction
Authors: Zimmerman William Denney , Pergakis Melissa , Ahmad Ghasan , Morris Nicholas A , Podell Jamie , Chang Wan-Tsu , Motta Melissa , Chen Hegang , Jindal Gaurav , Bodanapally Uttam , Simard J. Marc , Badjatia Neeraj , Parikh Gunjan Y 
Published: November 2023

Abstract

Background & Purpose:
Ischemia affecting two thirds of the MCA territory predicts development of malignant cerebral
edema. However, early infarcts are hard to diagnose on conventional head CT. We hypothesize
that high-energy (190keV) virtual monochromatic images (VMI) from dual-energy CT (DECT)
imaging enables earlier detection of secondary injury from malignant cerebral edema (MCE).
Methods:
Consecutive LHI patients with NIHSS ≥ 15 and DECT within 10 hours of reperfusion from May 2020 to March 2022 were included. We excluded patients with parenchymal hematoma-type 2 transformation. Retrospective analysis of clinical and novel variables included VMI Alberta Stroke Program Early CT Score (ASPECTS), total iodine content, and VMI infarct volume. Primary outcome was early neurological decline (END). Secondary outcomes included hemorrhagic transformation, decompressive craniectomy (DC), and medical treatment of MCE. Fisher’s exact test and Wilcoxon test were used for univariate analysis. Logistic regression was used to develop prediction models for categorical outcomes.
Results:
Eighty-four LHI patients with a median age of 67.5 [IQR 57,78] years and NIHSS 22 [IQR 18,25] were included. Twenty-nine patients had END. VMI ASPECTS, total iodine content, and VMI infarct volume were associated with END. VMI ASPECTS, VMI infarct volume, and total iodine content were predictors of END after adjusting for age, sex, initial NIHSS, and tPA administration, with a AUROC of 0.691 [0.572,0.810], 0.877 [0.800, 0.954], and 0.845 [0.750, 0.940]. By including all three predictors, the model achieved AUROC of 0.903 [0.84,0.97] and was cross validated by leave one out method with AUROC of 0.827.
Conclusion:
DECT with high-energy VMI and iodine quantification is superior to conventional CT ASPECTS and is a novel predictor for early neurological decline due to malignant cerebral edema after large hemispheric infarction.
Based on high-resolution CT, a predictive model for the development of infiltrative stage of 2-3cm pulmonary ground-glass nodules was constructed
Authors: Zhang Yifan , Qu Lin , zhang Haihua , Wang Ying , Gao Guizhou , Wang Xiaodong , Zhang Tao 
Published: November 2023

Abstract
Background: The purpose of this study was to analyze the imaging risk factors for the development of 2-3cm ground glass nodules (GGN) in the infiltrative stage, and to establish a nomogram prediction model for the pathological prediction of 2-3cm GGN.
Methods: We reviewed the demographic, imaging, and pathological information of 596 adult patients who underwent 2-3cmGGN resection between 2018 and 2022 in the Department of Thoracic Surgery, Second Affiliated Hospital of the Air Force Medical University. based on single factor analysis, regression method was used to analyze multiple factors, and a nomogram prediction model for 2-3cmGGN was established.
Results: 1. The risk factors for the development of 2-3cm GGN during the invasion stage were pleural depression sign (OR=1.687 95%CI 1.010-2.820), vacuole (OR=2.334 95%CI 1.222-4.460), burr sign (OR=2.617 95%CI 1.008-6.795), lobulated sign (OR=3.006 95%CI 1.098-8.227), bronchial sign (OR=3.134 95%CI 1.556-6.310) , diameter of GGN(OR=3.118 95%CI 1.151-8.445) , CTR (OR=172.517 95%CI 48.023-619.745). 2. The 2-3cmGGN risk prediction model was constructed according to the risk factors, with an AUC of 0.839; the calibration curve Y was close to the X-line; and the decision curve was drawn in the range of 0.0-1.0.
Conclusion: 1. The risk factors for the development of 2-3cm GGN during the invasion stage were pleural depression sign, vacuole, burr sign, lobulated sign, bronchial sign, diameter of GGN and CTR, the predictive model based on the above factors has some clinical significance.
Diagnosis and treatment of patients with rare uterine artery pseudoaneurysm: seven case series and review of the literature
Authors: tong longxia , xiao ping , wu lin 
Published: November 2023

Abstract
Background
Uterine artery pseudoaneurysm (UAP) is a rare but potentially life-threatening complication of traumatic pelvic operations and non-traumatic delivery/abortion. Due to the lack of awareness, UAP is often diagnosed after the occurrence of paroxysmal massive vaginal bleeding.
Methods
This was a retrospective study of seven patients with UAP in the West China Second University Hospital from January 2018 to August 2022.
Results
In this study, the average age of seven patients was 26.71 years. Six patients presented with a history of traumatic surgery, including cesarean scar pregnancy (CSP) (two patients), curettage for abortion (one patient), laparoscopic myomectomy (one patient), cervical conization (one patient), and curettage for gestational trophoblastic disease (one patient). The seventh patient underwent second-trimester pregnancy termination without a traumatic surgical procedure. The main symptom reported in patients was vaginal bleeding: three patients had paroxysmal massive vaginal bleeding amounting to more than 2000 mL. All the patients were confirmed using magnetic resonance imaging (MRI). Five patients underwent uterine artery embolization, and two patients were managed conservatively. One patient had massive vaginal bleeding again after bilateral transarterial embolization,MRI showed that the left UAP still existed, and finally transabdominal left internal iliac artery ligation and pseudoaneurysm resection were performed. All patients had good outcomes.
Conclusions
Seven patients with UAP were reviewed in this study, with their characteristic clinical symptoms, previous pelvic surgery, imaging features, treatment approaches, and prognosis described in detail and analyzed, hoping to provide new insights for the diagnosis or treatment of this rare life-threatening complication.
RNAi-mediated downregulation of AcCENH3 can induce in vivo haploids in onion (Allium cepa L.)
Authors: Manape Tushar K. , Satheesh Viswanathan , Somasundaram Saravanakumar , Soumia Parakkattu S. , Khade Yogesh P. , Mainkar Pawan , Mahajan Vijay , Singh Major , Anandhan Sivalingam 
Published: November 2023

Abstract

Haploid induction (HI) holds great promise in expediting the breeding process in onion, a biennial cross-pollinated crop. We used the CENH3-based genome elimination technique in producing a HI line in onion. Here, we downregulated AcCENH3 using the RNAi approach without complementation in five independent lines. Out of five events, only three could produce seeds upon selfing. The progenies showed poor seed set and segregation distortion, and we were unable to recover homozygous knockdown lines. The knockdown lines showed a decrease in accumulation of AcCENH3 transcript and protein in leaf tissue. The decrease in protein content in transgenic plants was correlated with poor seed set. When the heterozygous knockdown lines were crossed with wild-type plants, progenies showed HI by genome elimination of the parental chromosomes from AcCENH3 knockdown lines. The HI efficiency observed was between 0 and 4.63% in the three events. The HI efficiency was the highest (4.63%) when knockdown lines were used as male in crosses with wildtype. Given the importance of doubled haploids in breeding programmes, the findings from our study are poised to significantly impact onion breeding.