bluuebunny/crossref_metadata_2025_split huggingface dataset:
SMatStack to Enhance Noisy Teleseismic Seismic Phases: Validation and Application to Resolving Depths of Oceanic Transform Earthquakes
Authors: Fang Hongjian , Abercrombie Rachel E. 
Published: November 2023

AbstractThe depths of most moderate‐sized oceanic earthquakes are poorly constrained because of the lack of local recording stations and noisy teleseismic recordings. This hampers our understanding of slip behaviors along oceanic faults and the mechanical properties of the oceanic lithosphere. In this study, we develop a new method to enhance the weak body‐wave signals, particularly the depth phases, associated with earthquakes on oceanic transform faults using large‐aperture arrays in the teleseismic range. We simulate the enhanced teleseismic signals to refine the centroid depths of moderate‐sized earthquakes. We validate the new approach using synthetic waveforms and show it outperforms conventional methods when dealing with noisy signals. We obtain the depth estimates for three moderate‐sized earthquakes on the Chain transform fault in the equatorial Atlantic Ocean and find two of them are consistent with a local catalog derived using oceanic bottom seismometers. Application of the new method to the past decades of teleseismic recordings of moderate‐sized earthquakes on the large and slow‐slipping transform faults will provide significantly improved constraints on the width of the seismogenic zone, thus advancing our understanding of the rheology of oceanic lithosphere and earthquake processes in oceanic settings and, by comparison, their more dangerous continental counterparts. The new method is not limited to oceanic transform earthquakes, but can be easily adapted to other seismological studies in which noisy but coherent signals could be revisited for better usage.
Electron Backflow Motions in the Outer Electron Diffusion Region During Magnetic Reconnection
Authors: Xiong Q. Y. , Huang S. Y. , Yuan Z. G. , Jiang K. , Xu S. B. , Lin R. T. , Yu L. 
Published: November 2023

AbstractMagnetic reconnection is a fundamental physical process of rapidly converting magnetic energy into particles. The electron diffusion region (EDR) is the crucial region during magnetic reconnection. The outer EDR, which also plays a crucial role in magnetic reconnection, is responsible for energy conversion. In the outer EDR, the electrons are decelerated and return the energy to the magnetic field on the pileup region behind the reconnection front. In the present study, we used the fully kinetic particle‐in‐cell simulation and revealed that part of decelerated electrons in the outer EDR could even move back to the inner EDR. This phenomenon is caused by the dominant contribution from the magnetic tension force, and it suggests a magnetic Marangoni effect in space plasma, similar to the Marangoni effect in fluids. Our results potentially propose a brand‐new physical process and a novel mechanism in the EDR during magnetic reconnection.
Zonal Structure of Tropical Pacific Surface Salinity Anomalies Affects the Eastern and Central Pacific El Niños Differently
Authors: Guan Cong , Tian Feng , McPhaden Michael J. , Hu Shijian , Wang Fan 
Published: November 2023

AbstractMaximum sea surface salinity (SSS) anomalies are found in the central Pacific during the eastern Pacific El Niño (EPEN) and located further westward during the central Pacific El Niño (CPEN), but whether these differences affect event strengths is unclear. By performing ocean general circulation model experiments via modifying freshwater flux anomalies, we find salinity effects on surface warming during both types are highly sensitive to zonal locations of SSS anomalies, with the strongest warming induced by the SSS anomalies near the international dateline. Further analysis reveals that vertical mixing and entrainment dominate this temperature sensitivity, with the strongest response to SSS anomalies occurring in the central Pacific. The central‐Pacific SSS anomalies increase EPEN warming by 0.15°C while the westward‐located SSS anomalies make little contribution to CPEN warming. Therefore, the distinct zonal structures of SSS anomalies facilitate stronger EPEN than the CPEN, increasing their difference in intensity by about 10%.
Temperature Thresholds for Carbon Flux Variation and Warming‐Induced Changes
Authors: Fu Congsheng , Wang Guiling , Yang Yuting , Wu Huawu , Wu Haohao , Zhang Haixia , Xia Ye 
Published: November 2023

AbstractThe response of net ecosystem exchange (NEE) to environmental changes is strongly nonlinear, characterized with threshold behaviors that are not well understood. Here, we investigated the threshold behaviors in the relationship between NEE and surface air temperature based on FLUXNET2015 observations, Community Land Model simulations, and Coupled Model Intercomparison Project Phase 6 (CMIP6) model outputs. An air temperature threshold of 16.4°C, corresponding to the maximum carbon sink (Tsink), was identified for all 205 FLUXNET2015 sites combined. For deciduous broadleaf and mixed forests, wetlands and wheat‐barley croplands, and rice‐maize‐soybean croplands, we identified a carbon‐source threshold (Tsource) of 6.8, 5.0, and 18.0°C, respectively, beyond which the ecosystem becomes less of a carbon source. Five cold climate types mainly encompassing these plant functional types showed a clear carbon‐source Tsource of 12.2°C. Six CMIP6 models project a threshold temperature increase of 1.0–2.8°C by the 2090s, which results primarily from a shift of the optimum temperature for gross primary production. Not accounting for the warming‐induced threshold changes may lead to an estimated time of the average summer air temperature passing Tsink that is earlier by 4.5–6.7 and 6.4–12.2 years at low (15°N–15°S) and high (≥60°S or ≥ 60°N) latitudes, respectively.
The long-term health outcomes, pathophysiological mechanisms and multidisciplinary management of long COVID
Authors: Li Jingwei , Zhou Yun , Ma Jiechao , Zhang Qin , Shao Jun , Liang Shufan , Yu Yizhou , Li Weimin , Wang Chengdi 
Published: November 2023

AbstractThere have been hundreds of millions of cases of coronavirus disease 2019 (COVID-19), which is caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). With the growing population of recovered patients, it is crucial to understand the long-term consequences of the disease and management strategies. Although COVID-19 was initially considered an acute respiratory illness, recent evidence suggests that manifestations including but not limited to those of the cardiovascular, respiratory, neuropsychiatric, gastrointestinal, reproductive, and musculoskeletal systems may persist long after the acute phase. These persistent manifestations, also referred to as long COVID, could impact all patients with COVID-19 across the full spectrum of illness severity. Herein, we comprehensively review the current literature on long COVID, highlighting its epidemiological understanding, the impact of vaccinations, organ-specific sequelae, pathophysiological mechanisms, and multidisciplinary management strategies. In addition, the impact of psychological and psychosomatic factors is also underscored. Despite these crucial findings on long COVID, the current diagnostic and therapeutic strategies based on previous experience and pilot studies remain inadequate, and well-designed clinical trials should be prioritized to validate existing hypotheses. Thus, we propose the primary challenges concerning biological knowledge gaps and efficient remedies as well as discuss the corresponding recommendations.
Coordinated proteome change precedes cell lysis and death in a mat-forming cyanobacterium
Authors: Zorz Jackie , Paquette Alexandre J , Gillis Timber , Kouris Angela , Khot Varada , Demirkaya Cigdem , De La Hoz Siegler Hector , Strous Marc , Vadlamani Agasteswar 
Published: November 2023

Abstract
Cyanobacteria form dense multicellular communities that experience transient conditions in terms of access to light and oxygen. These systems are productive but also undergo substantial biomass turnover through cell death, supplementing heightened heterotrophic respiration. Here we use metagenomics and metaproteomics to survey the molecular response of a mat-forming cyanobacterium undergoing mass cell lysis after exposure to dark and anoxic conditions. A lack of evidence for viral, bacterial, or eukaryotic antagonism contradicts commonly held beliefs on the causative agent for cyanobacterial death during dense growth. Instead, proteogenomics data indicated that lysis likely resulted from a genetically programmed response triggered by a failure to maintain osmotic pressure in the wake of severe energy limitation. Cyanobacterial DNA was rapidly degraded, yet cyanobacterial proteins remained abundant. A subset of proteins, including enzymes involved in amino acid metabolism, peptidases, toxin-antitoxin systems, and a potentially self-targeting CRISPR-Cas system, were upregulated upon lysis, indicating possible involvement in the programmed cell death response. We propose this natural form of cell death could provide new pathways for controlling harmful algal blooms and for sustainable bioproduct production.
Narrative medicine pinpoints loss of autonomy and stigma in Parkinson’s disease
Authors: Florijn Barend W. , Kloppenborg Raoul , Kaptein Ad A. , Bloem Bastiaan R. 
Published: November 2023

AbstractParkinson’s disease characteristics can create a self-perceived sense of stigmatization and disapproval by others, thereby affecting self-perceived autonomy. This study investigated the metaphors related to the loss of autonomy and stigma in stories and drawings of Parkinson’s disease. We compare a contemporary first-person illness narrative and -drawing from a person with Parkinson’s disease, with two novels (Jonathan Franzen’sThe Correctionsand Claudia Piñeiro’s Elena Knows), a graphic novel(Peter Dunlap-Shohl’sMy Degeneration: A Journey Through Parkinson’s), a non-fiction book (Oliver Sacks’Awakenings) and a first-person illness narrative (John Palfreman’sThe Bright Side of Parkinson’s). Metaphors in the patient narrative, novels, and non-fiction work were reviewed and a list of themes or categorizations common to 2 of the metaphors was generated. Parkinson’s disease metaphors indicate a ‘Parkinson’s prism’ thereby depicting extreme experiences (24.4%) like a ‘fall by mischance’, a ‘tantrum of selfish misery’ or a ‘bottomless darkness and unreality’ (Table 1). Both novels signify a sense of ‘betrayal and disconnection’ in the Parkinson’s disease experience while non-fiction of Parkinsonism depicts aspacein which one feels ‘caged and deprived’. This makes the Parkinson’s disease narrative a chaos story that could influence the decision to initiate treatment and treatment adherence. We conclude that narrative medicine can help to focus the medical consultations with affected individuals on issues that matter most to them, thereby improving self-perceived autonomy and stigma. As such, it is a critical component of the much-needed move towards personalized medicine in Parkinson’s disease, achieved through the reciprocity of thinking with stories.
The effect of immunomodulatory drugs on aortic stenosis: a Mendelian randomisation analysis
Authors: Ciofani Jonathan L. , Han Daniel , Nazarzadeh Milad , Allahwala Usaid K. , De Maria Giovanni Luigi , Banning Adrian P. , Bhindi Ravinay , Rahimi Kazem 
Published: November 2023

AbstractThere are currently no approved pharmacological treatment options for aortic stenosis (AS), and there are limited identified drug targets for this chronic condition. It remains unclear whether inflammation plays a role in AS pathogenesis and whether immunomodulation could become a therapeutic target. We evaluated the potentially causal association between inflammation and AS by investigating the genetically proxied effects of tocilizumab (IL6 receptor, IL6R, inhibitor), canakinumab (IL1β inhibitor) and colchicine (β-tubulin inhibitor) through a Mendelian randomisation (MR) approach. Genetic proxies for these drugs were identified as single nucleotide polymorphisms (SNPs) in the gene, enhancer or promoter regions of IL6R, IL1β or β-tubulin gene isoforms, respectively, that were significantly associated with serum C-reactive protein (CRP) in a large European genome-wide association study (GWAS; 575,531 participants). These were paired with summary statistics from a large GWAS of AS in European patients (653,867 participants) to then perform primary inverse-variance weighted random effect and sensitivity MR analyses for each exposure. This analysis showed that genetically proxied tocilizumab was associated with reduced risk of AS (OR 0.56, 95% CI 0.45–0.70 per unit decrease in genetically predicted log-transformed CRP). Genetically proxied canakinumab was not associated with risk of AS (OR 0.80, 95% CI 0.51–1.26), and only one suitable SNP was identified to proxy the effect of colchicine (OR 34.37, 95% CI 1.99–592.89). The finding that genetically proxied tocilizumab was associated with reduced risk of AS is concordant with an inflammatory hypothesis of AS pathogenesis. Inhibition of IL6R may be a promising therapeutic target for AS management.
Effects of climatic and environmental factors on mosquito population inferred from West Nile virus surveillance in Greece
Authors: Ferraccioli Federico , Riccetti Nicola , Fasano Augusto , Mourelatos Spiros , Kioutsioukis Ioannis , Stilianakis Nikolaos I. 
Published: November 2023

AbstractMosquito-borne diseases’ impact on human health is among the most prominent of all communicable diseases. With limited pool of tools to contrast these diseases, public health focus remains preventing mosquito-human contacts. Applying a hierarchical spatio-temporal Bayesian model on West Nile virus (WNV) surveillance data from Greece, we aimed to investigate the impact of climatic and environmental factors on Culex mosquitoes’ population. Our spatio-temporal analysis confirmed climatic factors as major drivers of WNV-transmitting-Culex mosquitoes population dynamics, with temperature and long periods of moderate-to-warm climate having the strongest positive effect on mosquito abundance. Conversely, rainfall, high humidity, and wind showed a negative impact. The results suggest the presence of statistically significant differences in the effect of regional and seasonal characteristics, highlighting the complex interplay between climatic, geographical and environmental factors in the dynamics of mosquito populations. This study may represent a relevant tool to inform public health policymakers in planning preventive measures.
Causal effects of genetically determined blood metabolites on multiple myeloma: a Mendelian randomization study
Authors: Ren Jialin , Wu Min 
Published: November 2023

AbstractPrevious studies have shown that metabolites play an important role in phenotypic regulation. However, the causal relationship between metabolites and multiple myeloma has not been adequately investigated. Here, we attempt to explore the causal effects of genetically determined blood metabolites on multiple myeloma. The large-scale public blood metabolites and multiple myeloma datasets from independently published genome-wide association studies (GWAS) were used to explore the causal relationship between each genetically determined blood metabolite and multiple myeloma through inverse variance weighted (IVW), weighted median, MR-Egger and mode-based estimation methods. Sensitivity tests were performed to evaluate the stability and reliability of the results by MR-Egger regression and leave-one-out methods. Metabolic pathway analysis was further explored using filtered data. Statistical analyses were all performed in R. Among 452 metabolites, ten known metabolites and three unknown metabolites had significant causal relationship with multiple myeloma (P < 0.05). Four known metabolites, 3-methyl-2-oxovalenate, oxidized bilirubin, isovalerylcarnitine and glutamine carnitine, reached statistical significance in IVW models. Metabolic pathways analysis identified four significant pathways. The occurrence of multiple myeloma may have a causal relationship with these four metabolites, and there are four metabolic pathways that are also related to the occurrence of multiple myeloma. This can provide new ideas for exploring early screening and treatment of multiple myeloma.
Single-cell RNA sequencing revealed potential targets for immunotherapy studies in hepatocellular carcinoma
Authors: Xie Zhouhua , Huang Jinping , Li Yanjun , Zhu Qingdong , Huang Xianzhen , Chen Jieling , Wei Cailing , Luo Shunda , Yang Shixiong , Gao Jiamin 
Published: November 2023

AbstractHepatocellular carcinoma (HCC) is a solid tumor prone to chemotherapy resistance, and combined immunotherapy is expected to bring a breakthrough in HCC treatment. However, the tumor and tumor microenvironment (TME) of HCC is highly complex and heterogeneous, and there are still many unknowns regarding tumor cell stemness and metabolic reprogramming in HCC. In this study, we combined single-cell RNA sequencing data from 27 HCC tumor tissues and 4 adjacent non-tumor tissues, and bulk RNA sequencing data from 374 of the Cancer Genome Atlas (TCGA)-liver hepatocellular carcinoma (LIHC) samples to construct a global single-cell landscape atlas of HCC. We analyzed the enrichment of signaling pathways of different cells in HCC, and identified the developmental trajectories of cell subpopulations in the TME using pseudotime analysis. Subsequently, we performed transcription factors regulating different subpopulations and gene regulatory network analysis, respectively. In addition, we estimated the stemness index of tumor cells and analyzed the intercellular communication between tumors and key TME cell clusters. We identified novel HCC cell clusters that specifically express HP (HCC_HP), which may lead to higher tumor differentiation and tumor heterogeneity. In addition, we found that the HP gene expression-positive neutrophil cluster (Neu_AIF1) had extensive and strong intercellular communication with HCC cells, tumor endothelial cells (TEC) and cancer-associated fibroblasts (CAF), suggesting that clearance of this new cluster may inhibit HCC progression. Furthermore, ErbB signaling pathway and GnRH signaling pathway were found to be upregulated in almost all HCC tumor-associated stromal cells and immune cells, except NKT cells. Moreover, the high intercellular communication between HCC and HSPA1-positive TME cells suggests that the immune microenvironment may be reprogrammed. In summary, our present study depicted the single-cell landscape heterogeneity of human HCC, identified new cell clusters in tumor cells and neutrophils with potential implications for immunotherapy research, discovered complex intercellular communication between tumor cells and TME cells.
Complete C4-C5 Dislocation Secondary to Shallow Water Diving in a Child: A Case-Based Update
Authors: Matos Luís Eduardo Oliveira , Figueiredo Gabriel Sá , Monteiro Matheus Brasil Câmara , Esmeraldo Mateus Aragão , Ponte Keven Ferreira da , Cristino-Filho Gerardo , Leal Paulo Roberto Lacerda 
Published: November 2023

Abstract
Introduction Pediatric spinal cord injury (PSCI) is rare, especially secondary to shallow water diving, with only a few cases recorded in the literature. Due to the low standardization in the diagnosis and treatment of this condition, each of these cases requires a personalized approach.
Case Description A 10-year-old female patient presented with tetraparesis and C5 sensory level secondary to spinal trauma due to shallow water diving. Computed tomography (CT) revealed complete C4-C5 dislocation, which led to a neurosurgical approach preceded by an intraoperative manual maneuver to reduce the dislocation. Following complete surgical reduction of the dislocation, the patient presented immediate significant neurological improvement.
Conclusion Children need to be warned about diving, as SCI due to shallow water diving has a poor neurological outcome. Despite that, early diagnosis, stabilization, and surgical approach can lead to immediate significant neurological improvement. Considering the peculiarities of pediatric patients and the existence of varying care techniques in the literature, more studies comparing surgical and nonsurgical outcomes are fundamental.
Assessment of the Benefit of Intraoperative Cortical Stimulation in Patients with Lesions within Eloquent Brain Regions
Authors: Garcia Luiz Alberto Otoni , Giannetti Alexandre Varella 
Published: November 2023

Abstract
Objective The present study sought to evaluate the benefits of intraoperative cortical stimulation (CS) for reducing morbidity in neurosurgery.
Method A total of 56 patients were submitted to neurosurgical procedure with the aid of CS. Initially, surgical exposure and planned resection were based on anatomy and imaging exams, which were followed by CS. According to the findings, the patients were divided into two groups. In group 1 the previous surgical strategy had to be altered, while in group 2 the surgical planning did not suffer any interference. Patients were also divided into subgroups according to the underlying disease: gliomas or other etiologies. Transient and definitive deficits occurrence were compared between groups 1 and 2 and subgroups of etiologies. The real benefit of CS technique was calculated by a specific formula.
Results There were 20 patients (37.5%) whose surgical strategy was changed based on CS findings. Furthermore, 65% of group 1 patients had transient deficit, in comparison to 30.5% of patients in group 2 (p = 0.013). As for the definitive deficit, it occurred in 15.0% of group 1 patients versus 8.3% of patients in group 2 (p = 0.643). Definitive deficits with no statistical difference (p = 0.074) were found in 17.2% of patients with gliomas, while none were found in the other etiologies subgroup. The rate of real benefit of intraoperative CS was 30.4%. Considering the subgroups of gliomas and other etiologies, the benefit rates were 25.7% and 38.1%, respectively.
Conclusions The surgical decision was influenced by CS in 35.7% of the cases and prevented definitive deficit in 30% of patients.
Racing Performance and Sale Result in 145 Thoroughbreds after Arthroscopic Removal of Osteochondral Fragments from the Lateral Femoral Trochlear Ridge as a Yearling (2012–2015)
Authors: Kerbert Maria P. , Freeland Russell B. , Verhaar Nicole , Baker William T. 
Published: November 2023

Abstract
Objectives The lateral trochlear ridge (LTR) of the femur is the most common predilection site for osteochondritis dissecans (OCD) in the equine stifle. The objective was to investigate the relationship between lesion size, racing performance, and sale result of Thoroughbreds with LTR OCD following arthroscopic removal as a yearling.
Methods In this retrospective study, medical records of 145 Thoroughbreds from one equine hospital that underwent surgery for LTR OCD were reviewed; the length and depth of the lesions were measured on preoperative radiographs. Horses were allocated to group S if they were presented to a public yearling sale post-surgery, and horses in group NS were not. Each horse from group S was matched with two control horses from the same sale (group C). Influence of lesion size on racing performance and sale result was analyzed. Racing performance and sale results were compared between different categories of OCD lesion sizes and between the groups.
Results Lesion length and depth did not affect racing performance and did not differ between group S and group NS. However, group S did perform significantly better than group NS. When comparing groups S and C, there were no significant differences in racing performance and sale result.
Conclusion Thoroughbreds that had arthroscopic surgery for LTR OCD as a yearling and were presented on a public yearling sale performed comparable to Thoroughbreds that showed similar potential as a yearling. Sale result is not significantly affected in our study.