bluuebunny/crossref_metadata_2025_split huggingface dataset:
Mixed Conduction in Iodovanadate Glass-Nanocomposites: DC Conductivity, Hopping Frequency and Frequency Response Curves
Authors: Poddar Asmita , Roy Madhab , Ali Mir Sahidul , Chattopadhyay Dipankar , Halder Prolay , Bhattacharya Sanjib 
Published: December 2023

Abstract

Here, the system of amorphous semiconducting glassy system, xAgI − (1-x) (0.1CdO − 0.3 V2O5 − 0.4 P2O5 − 0.2ZnO) with x = 0, 0.05, 0.1, 0.2, 0.3, 0.4has been developed. The gradual change in the size of various nanocrystallites such as VO2, Zn2V2O7, V6O13, ZnV3O8 and P and the development of new phases of their combinations have been pronounced due to a gradual increase in AgI content. This may lead to the possible structural changes of the system under investigation. V-O-V vibration at lower energy may be responsible for weakening the covalent bond, which may be responsible for releasing vanadium ion to contribute more electron/ polaron. Correlated barrier hopping (CBH) model has been found to appropriate to predict the hopping conduction paths of charge carriers (or polarons) in pairs via current transfer between localized sites at the Fermi level. By incorporation of more and more AgI content in the composition, more bridging oxygen is expected to be formed in the composition and a strong covalent bonding between Ag+ and O− 2 may play dominating role for Ag+ transport over polaron hopping. Double activation energy corresponding to DC conductivity in a wide range of temperature may be considered as the signature of mixed conduction process in the present system.Estimated values of frequency exponent (n) may be highlighted to validate this mixed conduction process. Percolation type of motion of polaron may be predicted from the higher values of n for the as-prepared samples with higher AgIcontent. Similarly, three dimensional Ag+ motion may be the dominating charge carriers for the samples with higher AgI content as evident from the moderate values of n.A schematic conduction model has been proposed to explain the nature of electrical conductivity in the present system.
Rapidly progressive interstitial lung disease in the course of juvenile dermatomyositis: a case report
Authors: Oniszczuk Eliza Rebeka Siemaszko - , Jakubów Piotr , Tałałaj Mariola , Turczynowicz Aleksander , Konstantynowicz Jerzy 
Published: December 2023

Abstract
Background
Juvenile dermatomyositis is a systemic, autoimmune inflammatory muscle disorder and vasculopathy. While generally it is well-responsive to the standard line of therapy, in rare cases may develop life-threatening complications and show resistance to treatment. We presented the case of a 7-year-old, who developed rapidly progressive interstitial lung disease and pancreatic dysfunction in the course of fulminant juvenile dermatomyositis with a good outcome after aggressive immunosuppressive therapy with the use of rituximab. Our case illustrates the diagnostic challenges of this condition in the setting of non-specific clinical manifestations and a need for novel molecular mechanism-based treatment to improve the survival of refractory dermatomyositis.
Case presentation
A 7-year-old girl presented with erythematous rash, muscle weakness, pain of lower extremities and elevated body temperature. The patient was diagnosed with juvenile dermatomyositis through physical examination (typical skin manifestation, proximal muscle weakness) and based on the finding of elevated levels of serum muscle enzymes and myopathic EMG changes. In the course of the disease she developed interstitial lung disease rapidly progressing to respiratory dysfunction and pancreatic failure. She received combined therapy, including methylprednisolone pulse therapy, followed by intravenous immunoglobulin, both in maximum doses per kilogram. On the 20th day of hospitalization, she was admitted to the intensive care unit and placed on ventilation support. On the 11th day of assisted ventilation rituximab was administered. Because of pancreatic dysfunction, complicating the course of the disease, the child was placed on total parenteral nutrition. After 3 doses of rituximab her general state and respiratory condition showed gradual improvements. Eventually, after 23 days of ventilation support, the patient could be successfully extubated. When the enteral nutrition was re-established and the underlying disease reached the stage of satisfactory improvement she was discharged to an out-patient setting.
Conclusions
In juvenile dermatomyositis, rituximab may be a promising agent for treatment of rapidly progressive interstitial lung disease. It may also play a role in the therapy of simultaneous pancreatic dysfunction. In the future, the efficacy of rituximab in the refractory form of the disease should be further investigated.
EMPOWER-UP: psychometric evaluation of a generic questionnaire for assessing empowerment in relational decision-making and problem-solving among adults with long-term health conditions
Authors: Marqvorsen Emilie Haarslev Schröder , Petersen Morten Aagaard , Lund Line , Pouwer François , Thomsen Thordis , Mathiesen Anne Sophie , Rothmann Mette Juel , Jørgensen Rikke , Winkley Kirsty , Rasmussen Bodil , Skytte Tine Bruhn , Ntoumanis Nikos , Alexander Karyn , Zoffmann Vibeke 
Published: December 2023

Abstract
Background
Relational decision-making and problem-solving are powerful activities occurring daily across all healthcare contexts. Their empowering potential can be difficult to judge and is seldom fully exploited, and they can even be perceived as disempowering. This calls for assessment of the extent to which healthcare users perceive their interactions with healthcare providers as empowering. We developed a 36-item draft version of the generic EMPOWER-UP questionnaire deemed to have good face and content validity by healthcare users and researchers with expertise across multiple healthcare contexts. This article reports the psychometric properties of the Danish and English versions of the questionnaire.
Methods
A cross-sectional study was carried out among 526 adults diagnosed with diabetes, cancer, or severe mental illness in Denmark, United Kingdom, and Australia with recent (≤ 6 months) interaction with a healthcare provider. We evaluated structural validity, cross-cultural validity, and measurement invariance using confirmatory and exploratory factor analyses, item response theory modelling, and differential item functioning. Additionally, we evaluated empirical reliability and internal consistency.
Results
The final 24-item Danish and English versions of EMPOWER-UP has a three-factor second-order structure. The three factors of empowering mechanisms (14 items), disempowering mechanisms (6 items), and empowering insight (4 items) are connected through the second-order factor, realizing empowerment. Partial credit model calibration supported the use of summed subscale item scores, enhancing usability in clinical practice settings. Differential item functioning analysis demonstrated invariance across subgroups. Empirical reliability of the subscales was estimated at 0.85–0.95, and Cronbach’s alpha was 0.90–0.96.
Conclusions
The 24-item EMPOWER-UP questionnaire measuring empowerment in relational decision-making and problem-solving showed strong psychometric properties among adults with cancer, diabetes, and severe mental illness. Further evaluation in other contexts and populations is needed, including evaluation of construct validity, responsiveness to change, and test-retest reliability.
Alpha lipoic acid diminishes migration and invasion in hepatocellular carcinoma cells through an AMPK-p53 axis
Authors: Hidalgo Florencia , Ferretti Anabela C. , Etichetti Carla Borini , Baffo Emilia , Pariani Alejandro , Maknis Tomás Rivabella , Bussi Javier , Girardini Javier E. , Larocca María C. , Favre Cristián 
Published: December 2023

Abstract

Hepatocellular carcinoma (HCC) associated with viral or metabolic liver diseases is a growing cancer that lacks effective therapy. AMPK is downregulated in the early stages of HCC and its activation diminishes tumor progression in culture and in vivo. Alpha lipoic acid (ALA), an indirect AMPK activator that inhibits hepatic steatosis in rodents, shows antitumor effects in different cancers. We aimed to study the putative antitumor action of ALA in HCC cells through AMPK signaling. ALA led to significant inhibition of cell migration and invasion in HCC cells with wild-type TP53. We showed that these effects depended on AMPK, and ALA also increased the levels and nuclear compartmentalization of the AMPK target p53. The anti-invasive effect of ALA was abrogated in stable-silenced versus isogenic-TP53 cells. Furthermore, ALA inhibited epithelial-mesenchymal transition in control wild-type TP53, but no significant changes of EMT markers were observed in silenced TP53 cells. In addition, we spotted that in patients from the HCC-TCGA dataset some EMT genes showed different expression patterns or survival profiles depending on TP53 status. ALA emerges as a potent activator of AMPK-p53 axis in HCC cells, and it decreases migration/invasion by reducing EMT which could mitigate the disease in wild-type TP53 patients.
Novel long small RNAs (lsRNAs) are evolutionary conserved in plants and differentially expressed during epitype inducing conditions in Norway spruce embryos
Authors: Yakovlev Igor , Nakamura Miyuki , Viejo Marcos , Zhang Yupeng , Fossdal Carl Gunnar 
Published: December 2023

Abstract

Small non-coding RNA (sRNA) and the various other RNA species have tissue specific expression profiles. However, some size fractions may be missed or left out in the sequencing library preparation process, sequence data processing and downstream bioinformatic analysis. Here, we performed sRNA profiling in embryonic and vegetative tissues to elucidate a more complete picture of the gymnosperm sRNA populations than previously reported. We detected a novel group of sRNA between 31–34 nt in our Norway spruce sequencing data, with a prevalence in the 32–33 nt fraction, defined as the long small RNAs (lsRNAs). These lsRNAs were predominantly present in embryonic samples of Norway spruce. An in-silico analysis indicated that these lsRNA could originate from transfer RNAs (tRNA) and other non-coding transcripts and thus may target other non-coding RNAs (including tRNAs) or target repetitive elements such as transposons. We identified 18 putative orthologs of genes involved in Piwi-interacting RNA (piRNA) biogenesis but no spruce proteins were true homologs to the animal Piwi-proteins, thus lsRNAs cannot be considered as plant analogs to the animal piRNAs. Among the lsRNAs, tRNA-derived sequences from Asp, Glu and His iso-acceptors were in a majority and these sequences showed 3’ or 5’- bias dependent on the iso-acceptor type putatively targeted. The lsRNA sized fraction was detected in seeds of all the gymnosperms examined and in Arabidopsis thaliana, suggesting that these comprise a conserved type of sRNAs between gymnosperms and angiosperms. lsRNA levels differed significantly among tissue types and developmental stages, and interestingly their expression was impacted by epitype-inducing temperature conditions. The lsRNAs add to the complexity of the small RNA world and may play a role in epigenetic regulation of gene expression in plants.
Flexible Multi-Layered Security System: Secure 6G Mobile Network Considerations
Authors: Sr Tarek , El-Bendary Mohsen A. M. , Eltokhy Mostafa , Abouelazm Atef E. 
Published: December 2023

Abstract
The vision of 6G networks refers to linking undersea, terrestrial, and space networks together. This vision involves transferring a massive amount of data over the network. 6G network requires very high levels of security. This paper presents the proposed vision of 6G security. This paper focuses on security levels on 6G network. The paper proposes a multi-level security system that secures the data without affecting it. The multi-level security system consists of three security levels, which are two encryption techniques and a data hiding technique. The paper carried outmany simulation experiments to find the best integration of these techniques that provides the best security performance without affecting the data. The best simulation experiments that provided the best data security performance were the integration between 2D Logistic map, SVD, and Baker Map, respectively. This system provided the best simulation results for data security. The simulation results indicated a perfect match between the original message and the decryption original message after applying the system. The results also indicated that there was no effect on the data and no loss of data.
A Study of Online Academic Risk Prediction Based on Multivariate Time Series Features
Authors: Yu Mengping , Hou Rui , Huang Huan , Wu Yang , Fan Fulan , Yuan Shuai 
Published: December 2023

Abstract
Academic risk prediction is a hot topic in the field of big data in education that aims to identify and help students who experience great academic difficulties. In recent years, the use of machine learning algorithms to achieve academic risk prediction has garnered more attention and development. However, most of these studies use static statistics as features for prediction, which are slightly insufficient in terms of timeliness. To be able to capture students who have difficulties in course learning in a timely manner and to improve the academic performance of school students, this paper proposes a method based on multivariate time series features to predict academic risk. The method includes three steps: first, the multivariate time series feature is extracted from the interaction records of the students' online learning platforms; second, the multivariate time series feature transformation model ROCKET is applied to convert the multivariate time series feature into a new feature; third the new feature is converted into a final prediction result. Comparative tests show that the proposed method has high effectiveness.
An exploration of the impact of phylogenetic tree structure on NTI and βNTI estimates of community assembly
Authors: Gundersen Madeleine , Vadstein Olav 
Published: December 2023

Abstract

The nearest taxon index (NTI) and beta nearest taxon index (βNTI) are popular analytical tools for assessing the community assembly processes in a variety of ecosystems. However, the fundamental dependence of these models on the underlying phylogenetic tree is often overlooked and can potentially lead to erroneous conclusions. In this paper, we investigated how outlier sequences in the phylogenetic tree and reduction of the metacommunity richness affect estimates of the assembly processes. We estimated assembly in two datasets investigating fish-microbiota interactions. We found that outlier sequences can drastically change the interpretation of assembly processes. NTI consistently increased after outlier sequences were removed, which changed the ecological interpretation for 82.8% of the communities in one of the datasets. Similarly, βNTI was strongly affected by outliers in the phylogenetic tree, changing the ecological interpretation for 44.7% (Dataset 1) and 6.3% (Dataset 2) of the community comparisons. Lower metacommunity richness generally resulted in decreased NTI and increased βNTI, but the effect sizes were small and generally did not result in a change in ecological interpretation. This exploratory work highlights the need to assess the phylogenetic tree for spurious outlier sequences prior to null model analysis.
Brain Connectivity Analysis Based Classification of Obstructive Sleep Apnea using Electroencephalogram Signals
Authors: Rajeswari J. , Jagannath M. 
Published: December 2023

Abstract
Obstructive sleep apnea (OSA) is a disorder which blocks the upper airway during sleep. The severity of OSA will lead heart attack, stroke and end of life. This proposed study explored the classification of OSA and healthy subjects using brain connectivity analysis from electroencephalogram (EEG) signals. ISRUC database were used for acquiring 50 EEG signals using 4 channels and noise removal has been accomplished by 50 Hz notch filter. Wavelet packet decomposition method was performing the segregation of EEG signals into five bands; Gamma (γ), beta (β), alpha (α), theta (θ) and delta (ẟ). A total of 4 electrode positions were used for the brain connectivity analysis for each EEG band. Pearson correlation method was effectively used for measuring the correlation between healthy and OSA subjects. The nodes and edges were highlighted the connection between brain and subjects. The highest correlation was achieved in delta band of OSA subjects which starts from 0.7331 to 0.9172 respectively. For healthy subjects, the positive correlation achieved was 0.6995. The delta band has been correlated well with brain when compared other bands. It has been noted that the positive correlation well associated with brain in OSA subjects, which classifies OSA from healthy subjects.
OCL2NL: Automatic Generation Natural Language Description from OCL Contracts
Authors: Yang Yilong , Li Qizhen , Niu Nan , Liu Yibo , Bao Tianshu 
Published: December 2023

Abstract
Formal contracts play a crucial role in precisely specifying system requirements and facilitating the verification of system implementation through automated test case generation or formal verification techniques, particularly in the development of safety-critical systems. The Object Constraint Language (OCL) is a lightweight formal language widely utilized for expressing constraints in UML-based models. However, due to the semantic gap between OCL expressions and their interpretations, comprehending OCL contracts can be challenging.In this paper, we propose a novel approach called OCL2NL, which enables the automatic generation of natural language descriptions from OCL contracts. OCL2NL encompasses a comprehensive set of translation rules and algorithms that map OCL contracts to semantic and signature descriptions of system operations. To validate our approach, we conduct four case studies. The results demonstrate a high success rate, with 97.06% of the OCL expressions and 87.68% of the signatures generating accurate descriptions. Moreover, domain experts evaluate that 50 out of 52 descriptions of OCL expressions and 11 out of 12 signature descriptions effectively capture essential information about the corresponding OCL contracts. The natural language descriptions significantly enhance the understanding of OCL contracts when compared to the contracts alone. Overall, the results are promising, indicating the potential extension of our proposed approach within the software industry.
Overall performances of Leucaena leucocephala and Morus alba in high-density shrub fodder banks at maturity in western Burkina Faso Running head: Performance of High-density fodder banks for livestock feeding
Authors: Sib Ollo , González-García Eliel , Vall Eric 
Published: December 2023

Abstract

The objective of this work was to carry out a long-term monitoring of shrub fodder banks (SFB), established under the real-low-input-farm conditions of Burkina Faso, characterised by a Sudano-Sahelian climate type with wide variations in rainfall. The SFBs, which were planted in 2016-2017 with Leucaena leucocephala (LL) and Morus alba (MA) at a high-density (20,000 plants/ha), were monitored from 2016/2017 to 2021 for their biomass (fodder) production, chemical composition and nutritive value of the edible forage, and their impacts on soil carbon content. The average annual forage production of LL for the 6 SFBs (1, 2, 3, 4, 5 and 6) was 11.4 ± 2.12 t DM/ha/year while that of MA was 3.8 ± 1.2 t DM/ha/year for the 3 SFB (1, 2, and 3). Such differences are likely related to higher adaptive capacity for LL in such climatic conditions. The high nutritive value observed in both fodder resources agreed with available literature worldwide. Crude protein was higher in LL (19% vs. 17%), but dry matter digestibility (65% vs 77%) were superior in MA. Soil carbon increased during the five monitored years, which is an interesting result for these poor, low fertility soil conditions. Our results demonstrate the technical and environmental feasibility for establishing this low-input agroforestry technology in these conditions, as an agroecological alternative to overcoming feed shortages for local livestock farming. However, the successful management of a SFB relies on the selection of the right species, the protection provided, and the management during the establishment and fodder production periods, with suitable cutting frequency and appropriate post-harvest management.
Human-Machine Cooperative Program Translation Based on Abstract Syntax Tree
Authors: Zhang Fengming , Liu Jiaqi , Yu Zhiwen , Guo Bin 
Published: December 2023

Abstract

Program translation involves converting one programming language into another, which can modernize and migrate applications across platforms. Most of the current program translation methods are sequence-based, which cannot capture the semantic information of the code. To overcome this, abstract syntax tree-based program translation rises up. However, even the state-of-the-art machine translation methods can not guarantee error-free translation results. Consequently, software engineers need to make corrections on the machine's results before using, which is labor-intensive. To solve this problem, we propose the Human-Machine Cooperative Program Translation Based on Abstract Syntax Tree (HMPT-AST), which feeds the human's modification into the model in each iteration and the model updates the result based on human's feedback. It enables two patterns of human participation: First-error-based and Layer-based HMPT-AST. In the former one, the software engineer corrects one error node in each iteration. In the latter one, all error nodes within the same layer are corrected. In addition, the proposed method can also reduce the interactive response time from two aspects: avoiding generating the correct AST subtree repeatedly with parameter cache module, as well as reducing the generation of unnecessary AST subtree with early termination module. We conducted experiments on multiple dataset. The results show that compared with baselines, our method reduces the human effort up to 94.44\% and reduces the response time up to 94.32\%. We have made the code publicly available.\footnote{https://drive.google.com/drive/folders/1878Or6cEsW21fu_cpdpnv_dGevfFr9mB?usp=sharing}