bluuebunny/crossref_metadata_2025_split huggingface dataset:
The tobacco GNTI stem region harbors a strong motif for homomeric protein complex formation
Authors: Schoberer Jennifer , Izadi Shiva , Kierein Carolina , Vavra Ulrike , König-Beihammer Julia , Ruocco Valentina , Grünwald-Gruber Clemens , Castilho Alexandra , Strasser Richard 
Published: November 2023

IntroductionThe Golgi apparatus of plants is the central cellular organelle for glycan processing and polysaccharide biosynthesis. These essential processes are catalyzed by a large number of Golgi-resident glycosyltransferases and glycosidases whose organization within the Golgi is still poorly understood.MethodsHere, we examined the role of the stem region of the cis/medial Golgi enzyme N-acetylglucosaminyltransferase I (GNTI) in homomeric complex formation in the Golgi of Nicotiana benthamiana using biochemical approaches and confocal microscopy.ResultsTransient expression of the N-terminal cytoplasmic, transmembrane, and stem (CTS) regions of GNTI leads to a block in N-glycan processing on a co-expressed recombinant glycoprotein. Overexpression of the CTS region from Golgi α-mannosidase I, which can form in planta complexes with GNTI, results in a similar block in N-glycan processing, while GNTI with altered subcellular localization or N-glycan processing enzymes located further downstream in the Golgi did not affect complex N-glycan processing. The GNTI-CTS-dependent alteration in N-glycan processing is caused by a specific nine-amino acid sequence motif in the stem that is required for efficient GNTI-GNTI interaction.DiscussionTaken together, we have identified a conserved motif in the stem region of the key N-glycan processing enzyme GNTI. We propose that the identified sequence motif in the GNTI stem region acts as a dominant negative motif that can be used in transient glycoengineering approaches to produce recombinant glycoproteins with predominantly mannosidic N-glycans.
The effects of binge drinking on attention in young adults
Authors: Monds Lauren A. , Singleton Matthew R. , Russell Alex M. T. 
Published: November 2023

IntroductionAlcohol binge drinking is highly prevalent among young adults. While research has established the neurotoxic effects of general alcohol consumption, binge drinking presents unique deleterious effects on the brain through the acute intoxication and withdrawal cycle. The detrimental impacts of binge drinking have been reported across a broad range of cognitive abilities in young adults, however, the research regarding its relationship to attention is mixed. This study investigates the relationship between binge drinking and attention performance in young adults. Moreover, there is evidence to suggest that males and females are uniquely impacted by the neurotoxic effects of binge drinking, so the present study tests the moderating role of sex, as well as the influence of earlier age of binge drinking onset.MethodsOne-hundred and five university students were recruited for the study. After collecting socio-demographic, and alcohol use information, participants completed four cognitive tasks designed to measure the three attention networks according to the Attention Network Theory; alerting, orienting, and executive control. Linear hierarchical regressions were used to predict performance with binge drinking score, sex and age of first binge drinking session as predictors.ResultsBinge drinking, sex, and age of first binge drinking session did not predict attention impairment, nor did sex moderate the relationship, at least in the selected cognitive tasks. The tasks used to measure attention did not relate in the expected manner.DiscussionWhile there were no differences in attention performance between those who binge drink and controls in this study, the relationship between binge drinking and attention impairments in young adults may be more nuanced and future research directions are suggested. Theoretical and practical implications of these findings are discussed.
“Without it, I am not sure I would still be here”: a mixed methods service evaluation for online EMDR trauma therapy in a primary care network in England
Authors: Kaptan Safa Kemal , Dernedde Carsten , Dowden Tilda , Akan Ayşe 
Published: November 2023

IntroductionPsychological services are typically offered via specialized mental health services, which are often overwhelmed with long waitlists. To address this need and provide patients with a service characterized by shorter waiting times and increased accessibility, online Eye Movement Desensitization and Reprocessing (EMDR) was established in the North Norfolk 4 Primary Care Network.MethodsThis article presents this service’s collaborative funding, development and outcomes within local GP surgeries. It constitutes a mixed-method service evaluation encompassing the future of EMDR in primary care services. Additionally, it includes the assessment of anxiety, depression, and PTSD symptoms as well as work and social adjustment in a cohort of 83 patients alongside a Thematic Analysis involving eighteen patients and six GPs.ResultsThe evaluation showed high completion and attendance among service users. Quantitative scores combined with qualitative feedback from patients and practitioners highlight the potential impact of EMDR therapy on General Practice and its broader provision of trauma-focused therapies. The most significant improvements were observed in anxiety and depression scores. Thematic Analysis indicated that the patients found the service helpful, labeling it as a “life-saver.” They also discussed why they found the service effective; some also wished the service had been available earlier.DiscussionFindings underscore the potential of EMDR and online EMDR as an accessible and effective approach within primary care settings. The assessments showed an elevated level of access and attendance among service users. Therefore, it is recommended that timely EMDR services be extended through primary care networks.
Mediating effects of depression on sleep disturbance and frailty in older adult type 2 diabetes patients in the community
Authors: Chen Xushu , Liu Mengdan , Ma Qin , Liu Xin , Peng Xueping , He Changjiu 
Published: November 2023

IntroductionWith the progressive aging of the population, frailty is now a significant challenge in geriatrics research. A growing amount of evidence suggests that sleep disturbance and depression have independent effects on frailty, although the underlying mechanisms are not yet clear. This study aimed to investigate the mediating role of depression in the relationship between sleep disturbance and frailty in older adult patients with type 2 diabetes (T2DM) in the community.MethodPurposive sampling was used to collect face-to-face data from 342 community-dwelling T2DM patients in Chengdu, Sichuan Province, China, between February and May 2023. The Pittsburgh Sleep Quality Index (PSQI) scale was used to evaluate sleep quality, the Simple Geriatric Depression Scale (GDS-15) was used to evaluate depressive symptoms, and the FRAIL Scale (FRAIL) was used to evaluate frailty. Linear regression equation and bootstrap self-sampling were used to verify the mediating role of depressive symptoms in sleep disturbance and frailty.ResultThe study found that sleep disturbance had a direct positive effect with frailty [β = 0.040, 95% CI: (0.013, 0.069)]. Additionally, depression had a direct positive effect on frailty [β = 0.130, 95% CI: (0.087, 0.173)], and depression was found to partially mediate the relationship between sleep disturbance and frailty.ConclusionPoor sleep quality and frailty are common in patients with T2DM. To reduce the frailty of older adult T2DM patients, all levels of society (government, medical institutions, and communities) must pay more attention to mental health. A variety of interventions should be considered to improve sleep quality and depression, which in turn may prevent or control frailty.
Health-related quality of life of Korean older adults according to age, sex, and living arrangements: a cross-sectional study
Authors: Hwang Horim A. , Jeong Hyunsuk , Yim Hyeon Woo 
Published: November 2023

IntroductionThe number and proportion of older adults living alone is a significant issue. While the number of the oldest old people is also expected to increase, their health characteristics are poorly understood. This study aims to evaluate the health-related quality of life (HRQoL) of the oldest old people according to age, sex, and living arrangements.MethodsThis study is based on the Korea Community Health Survey 2021. Among the survey's 229,242 observations, 73,617 observations aged 65 or higher were used for the analysis. The study participants were divided into 5-year age intervals (from 65–69 to 90+), sex, and living arrangements. The outcome variables are the EuroQol 5 Dimensions (EQ-5D) index score and the problem reporting rates of the five dimensions of EQ-5D.ResultsThe mean EQ-5D index scores were 0.896 at 65–69 and 0.741 at 90+. The mean EQ-5D index score decreased more rapidly as age increased. Women showed consistently lower mean EQ-5D index scores than men in all age intervals. The proportion of older adults living alone increased from 18.1% at 65–69 to 43.6% at 90+. The odds of reporting problems with anxiety/depression among older men living alone were estimated to be significantly higher than older men living with someone (aOR 1.22 95% CI 1.05–1.43). The odds of reporting problems in self-care and usual activity among older women living alone were estimated to be significantly lower than older women living with someone (aOR 0.88 95% CI 0.70–0.83 and aOR 0.88 95% CI 0.82–0.94)ConclusionThis study showed that older adults' HRQoL deteriorates as their age increases. Moreover, living alone may lead to different effects on older adults' HRQoL according to sex. More comprehensive studies and collaborative attention are needed to identify and provide customized care for older adults.
Effective Potential for Quintessential Inflation Driven by Extrinsic Gravity
Authors: Capistrano Abraão J. S. , Cabral Luís Antonio 
Published: November 2023

We numerically study the evolution of the extrinsic energy density in the context of an inflationary regime at the background level in a five-dimensional model using a Bayesian analysis from a dynamic nested sampler (DYNESTY) code. By means of the Nash–Greene embedding theorem, we show that the corresponding model provides an effective potential driven by the influence of extrinsic geometry. We obtain a quintessential inflation that defines a model with a potential V(ϕ)=e−α1ϕ(1−α2ϕ2), where α1 and α2 are dimensionless parameters. Using some known phenomenological parameterizations, such as Chevallier–Polarski–Linder (CPL) and Barboza–Alcaniz (BA) parameterizations, we show that the model reflects a slow-varying inflation preferring a thawing behavior, suggesting an optimistic scenario for further research on the unification of inflation with late cosmic acceleration.
The Relationship Between Personality and Language: the Concept of Linguistic Personality in Clinical and Psychological Discourse
Authors: Сизова Н.С. , Семенова Н.Д. 
Published: November 2023

В статье представлен обзор различных подходов к осмыслению понятия языковой личности в междисциплинарном дискурсе. Даны традиционные лингвистические определения понятия, а также описаны варианты применения термина в психологии и психиатрии. Описана модель языковой личности, и обсуждается возможность ее применения в диагностических целях в клинико-психологической практике. Обсуждается возможность применения психологических методик для выявления взаимосвязи личностных черт и речевых особенностей личности. В статье также рассматривается новый термин – «измененная языковая личность». Термин предлагается авторами для обозначения изменений, предстающих или проявляющихся в языковой личности на фоне психического заболевания. В статье постулируется значимость применения междисциплинарного взгляда на изучение психических заболеваний, в частности шизофрении, изменения личности при которой являются одним из ведущих симптомов проявления болезни.
The article presents an overview of different approaches to the concept of linguistic personality in interdisciplinary discourse. Traditional linguistic definitions of the concept are given, and also variants of application of the term in psychology and psychiatry are described. The model of linguistic personality is described and the possibility of its application for diagnostic purposes in clinical and psychological practice is discussed. Possibility of application of psychological techniques for revealing of interrelation of personality traits and speech features of personality is discussed. The article also considers a new term – "altered linguistic personality". The term is offered by the authors to designate the changes which appear or appear in the language personality against the background of mental disease. The article postulates the importance of applying an interdisciplinary view to the study of mental illness, in particular schizophrenia, in which personality changes are one of the leading symptoms of the manifestation of the disease.
MENGEMBANGKAN KEMAMPUAN PERENCANAAN KARIR MELALUI BIMBINGAN KELOMPOK DENGAN SHORT MOVIE IMPIAN
Authors: Husniah Wa Ode , Safaria Ria , Sri Rahmah Maria Ulfa; 
Published: November 2023

Desa Koholimombono merupakan salah satu desa yang ada di Kabupaten Buton, Sulawesi Tenggara. Para remaja yang ada di Desa Koholimombono hampir 80% tidak melanjutkan ke jenjang perguruan tinggi setelah tamat Sekolah Menengah Atas (SMA) dan juga tidak memiliki pekerjaan tetap (menganggur) serta tidak memiliki perencanaan karir di masa depan. Perencanaan karir yang baik membawa sikap positif dan optimis, ditunjukkan dengan persiapan perencanaan yang matang. Media film pendek dengan judul impian dapat membantu remaja SMA dalam memahami materi yang disampaikan sehingga remaja memiliki pemikiran kritis dan menerapkannya dalam kehidupan sehari-hari. Dengan penggunaan film pendek ini juga membuat remaja mendapatkan informasi dari pengalaman performasi, vikarius, persuasi verbal maupun emosional yang akan membentuk suatu pemahaman baru pada diri remaja yang berhubungan dengan karir masa depannya.
Le portrait de già en italien : entre identité sémantique et variation
Authors: Khachaturyan Elizaveta 
Published: November 2023

Traditionnellement, quatre types d’emplois caractérisent già. Ce sont les emplois définis comme les emplois temporels, de renforcement, scalaires et les emplois absolus. Dans notre étude, nous formulons au départ une hypothèse sur l’identité sémantique de già à l’œuvre dans tous ses emplois. Gia est défini comme une particule énonciative jouant un rôle essentiel dans la construction du discours. La séquence p – portée de già – correspond au maintenant du discours, dans un rapport de discontinuité avec le contexte gauche, noté p’. Nous distinguons cinq grands types de variation de già où, en fonction du rapport entre p et p’, son identité sémantique se déploie de façon spécifique. Ces cinq types de variations sont décrits sur la base d’une analyse d’exemples authentiques.
Haəy, verbe, particule et coordonnant en khmer
Authors: Paillard Denis 
Published: November 2023

Dans les dictionnaires français-khmer et dans les dictionnaires khmer-français, haəy est donné comme la traduction de déjà. Dans les faits, le mot haəy a différents statuts : comme verbe il signifie « être fini » ; il a également différents emplois non verbaux, en particulier comme particule et comme coordonnant. On le rencontre aussi dans différentes locutions : lie haəy (litt. « quitter » + haəy) « au revoir, à plus » ou encore haəy knie (litt. haəy + « ensemble ») « nous sommes ex-aequo » (par exemple, dans un jeu). De plus, dans ses emplois comme particule, la traduction par déjà est en fait rarement possible. Cet article propose une analyse de haəy dans ses différents emplois en partant d’une hypothèse sur son identité sémantique. On fera une distinction entre les emplois de haəy comme verbe (comme verbe principal ou comme verbe dans une construction verbale en série), et ses emplois comme particule et comme coordonnant. Dans ces deux derniers emplois, de loin les plus fréquents, nous caractérisons haəy comme marquant une discontinuité discursive : la séquence correspondant à la portée de haəy a un effet stabilisant (particule) ou clôturant (coordonnant) dans l’enchaînement discursif et, à ce titre, il définit le maintenant du discours.
À propos des particules russes uže et už
Authors: Bottineau Tatiana 
Published: November 2023

Consacré aux particules russes uže et už traduites toutes les deux par « déjà », l’article vise à montrer que leur synonymie n’est que partielle. Ces deux unités ont une étymologie commune, elles construisent en synchronie une altérité sur la valeur p qu’elles portent et mettent en place une discontinuité discursive. Mais uže et už diffèrent par leur mode opératoire et par le contenu de l’altérité qu’ils construisent. Le fonctionnement respectif des deux particules obéit cependant à des principes stables et réguliers qui permettent de proposer la description de leur variation sémantique déterminée à la fois par les paramètres étymologiques, contextuels et discursifs.Uže caractérise la relation entre la valeur p et le repère temporel t comme en adéquation avec la réalité objective. Son mode opératoire est décrit à travers deux configurations, l’altérité t/t’ (validation tardive ou anticipée de p) et l’altérité p/p’ (validation ou l’absence de validation de p au moment de référence t).Už recentre la discussion sur l’adhésion du locuteur à p sélectionné et validé par lui au moment de la parole t. La variation sémantique de už rend une forte dimension subjective et modale qui varie en fonction des contextes (pertinence, mise en doute, hypothèse, acceptation de p, etc.).
De la discontinuité dans le discours : le cas de jau en letton
Authors: Vladimirska Elena , Turlā-Pastare Daina 
Published: November 2023

La présente recherche porte sur le mot letton jau. Nous proposons de considérer les différents emplois de jau en tant que variations de son identité sémantique qui consiste, selon nous, en la création d’un « maintenant » du discours en discontinuité avec ce qui précède (le contexte gauche). A partir d’un corpus écrit et oral, et en fonction d’un certain nombre de variables, parmi lesquelles : la mise en jeu de la temporalité (t), la nature de p (l’énoncé qui constitue la portée de jau), les caractéristiques distributionnelles, etc., nous distinguons quatre valeurs majeures de jau : valeur aspecto-temporelle, valeur argumentative, valeur endoxale et valeur confrontant deux points de vue. Nous étudions également les combinaisons de jau avec d’autres marqueurs discursifs – phénomène très fréquent en letton – en cherchant à révéler les enjeux discursifs et énonciatif dont ils sont les marqueurs. Notre recherche s’inscrit dans le cadre de la théorie des opérations énonciatives d’Antoine Culioli, et présente une contribution à l’étude des unités lexicales de différentes langues dans la diversité de leurs emplois.
A ADIPOSIDADE CORPORAL E A AMPLITUDE ARTICULAR DE OMBROS PODEM INFLUENCIAR NO DESEMPENHO DA FORÇA EXPLOSIVA DOS MEMBROS SUPERIORES EM LANÇADORES PARALÍMPICOS?
Authors: Oliveira José Igor Vasconcelos de , Silva Lucas Romeu da , Gomes Laís Polyane Assis , Alves João Fillype Vasconcelos Viana , Bezerra Dantas Matheus Jancy , Arruda Sidcley Felix , Oliveira Saulo Fernandes Melo de 
Published: November 2023

Esse estudo teve como objetivo identificar variáveis clínico-demográficas antropométricas, morfológicas e de composição corporal, correlacionando com o desempenho do teste de medicine ball em atletas de lançamento paralímpico. Foram avaliados 8 atletas por um questionário sociodemográfico e de nível competitivo, determinação da área muscular do braço por meio da circunferência dos membros superiores, avaliação da adiposidade corporal da espessura das dobras cutâneas triciptal, biciptal, abdominal, supra ilíaca, escapular, axilar, coxa medial e panturrilha e o desempenho da potência por meio do teste de medicine ball. Foi realizado um teste de regressão linear simples com o intuito de correlacionar as variáveis observadas e os resultados do arremesso de medicine ball. Adotou-se p<0.05. Como principal resultado, o desempenho no teste de medicine ball obteve significância com os resultados da morfologia do membro superior (R2=0,712; p=0,016) e com a adiposidade axial (R2=0,790; p=0.007), contudo, observou-se um nível de correlação interessante também com a adiposidade apendicular (R2=0,517), contudo sem significância estatística. Entende-se, portanto, a adiposidade axial e apendicular com o arremesso de medicine ball indicando que esses fatores podem influenciar no desempenho da força explosiva dos membros superiores em lançadores paralímpicos, indicando que o medicine ball pode ser uma ferramenta de avaliação e monitoramento da potência em diferentes momentos de uma temporada competitiva.
Recebido em: 23/11/2022
Reformulado em: 26/03/2023
Aceito em: 04/04/2023
Soil microbial properties are improved by the adoption of soil management and conservation practices in no-tillage system
Authors: Spliethoff Jhonatan , Knob Adriana , Rampim Leandro , Müller Marcelo Marques Lopes , Pott Cristiano Andre 
Published: November 2023

ABSTRACT

No-tillage system (NTS) plays a prominent role in conservation agriculture, however, its benefits can be further improved by adopting complementary soil management and conservation practices, such as using autumnal cover crops, contour seeding, and terraces. This study aimed to evaluate how soil biological activity responds to soil management and conservation systems. The treatments consisted of three macroplots with an area of 11.000 m
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each, as follows: a) Non-Terraced catchment (NTC), cultivated in NTS similar to most farmers of the region, in which the agricultural operations are carried out in the direction of the slope and without terraces used; b) Best Management Practices (BMPs) were adopted in NTS with additional autumnal cultivation of cover crops, and also the direction of machine traffic was transverse to the slope direction; and c) Terraced catchment (TC), cultivated in NTS was associated to mechanical practices to erosion control, using wide base terrace on level. Soil microbial properties sampled in the 0.00-0.10 m layer were evaluated during 2019, 2020, and 2021, all shortly after the summer crop harvest. Natural inoculum potential of arbuscular mycorrhizal fungi (AMF), respirometry, metabolic coefficient, acid phosphatase activity, and organic carbon and nitrogen in the microbial biomass were assessed. Averages of each microbiological properties were compared through the confidence intervals (p<0.05). The results showed a greater potential for AMF inoculum in BMPs and TC systems. The NTC showed the highest values of respirometry and metabolic quotient, releasing 31.7 and 27.3 % more CO
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compared to BMPs and TC, respectively. The BMPs and TC were able to retain 13.8 and 16.5 % more carbon in the microbial biomass and 8.0 and 8.8 % more nitrogen in the biomass than NTC, respectively. Adopting soil management and conservation practices such as autumn cover crops, level seeding, and wide base terrace on level improved the soil microbial properties, with an increase in AMF inoculum potential, higher levels of acid phosphatase activity, and increment of carbon and nitrogen in microbial biomass.