bluuebunny/crossref_metadata_2025_split huggingface dataset:
Identification of retinol dehydrogenase 10 as a shared biomarker for metabolic dysfunction-associated steatotic liver disease and type 2 diabetes mellitus
Authors: Li Fangyu , Li Rui , Deng Hongjun 
Published: January 2025

BackgroundMetabolic dysfunction-associated steatotic liver disease (MASLD) is an independent risk factor for type 2 diabetes mellitus (T2DM), and its early identification and intervention offer opportunities for reversing diabetes mellitus.MethodsIn this study, we identified biomarkers for the MASLD dataset (GSE33814, GSE48452) and the T2DM dataset (GSE76895 and GSE89120) by bioinformatics analysis. Next, we constructed weighted gene co-expression network (WGCNA) for disease module analysis to screen out shared genes strongly associated with diseases. We also analyzed the enriched pathways of shared genes using Gene Ontology (GO) and Kyoto Encyclopedia of Genes and Genomes (KEGG) pathways. Next, hub gene validation was performed using the least absolute shrinkage and selection operator (LASSO) and receiver operating characteristic (ROC) curves. Finally, we used RT-qPCR, immunofluorescence, Western blotting and Elisa to validate hub gene expression in MASLD and T2DM mouse models.ResultsThis analysis identified 20 genes shared by MASLD and T2DM that were enriched in the bile secretion, phototransduction, cancer, carbohydrate digestion and absorption, cholesterol/glycerol metabolism, and retinol metabolism. The LASSO algorithm and ROC curve identified Retinol Dehydrogenase 10 (RDH10) as the best diagnostic gene for MASLD and T2DM. Immunofluorescence and Western blot showed that RDH10 expression was reduced in the liver and pancreatic islets of MASLD and T2DM model mice. Similarly, serum levels of RDH10 were significantly lower in MASLD and T2DM model mice and humans than in controls.ConclusionOur study suggests that RDH10 is a common diagnostic marker for MASLD and T2DM and provides new research directions for the prevention and treatment of MASLD and T2DM.
Adaptive cognitive control in 4 to 7-year-old children and potential effects of school-based yoga-mindfulness interventions: an exploratory study in Italy
Authors: Toffoli Lisa , Stefanelli Giulia , Manca Giulia , Del Popolo Cristaldi Fiorella , Duma Gian Marco , Guidi Michele , Incagli Francesca , Sbernini Luca , Tarantino Vincenza , Mento Giovanni 
Published: January 2025

IntroductionRecent findings showed that adaptive cognitive control (CC) can be instantiated by bottom-up mechanisms, including statistical contingency of event occurrence. However, the developmental evidence in this domain remains limited.MethodsTo address this gap, our study delves into the exploration of different mechanisms underlying adaptive CC in a substantial cohort of young children (211 participants aged between 4 and 7 years). We utilized the Dynamic Temporal Prediction (DTP) task and a modified version of the Flanker task to assess the effect of context predictability on motor preparation/inhibition and interference control, respectively. Furthermore, as part of an exploratory study designed to evaluate the feasibility of a school-based program in Italy, all children underwent a re-testing session after an 8-week intervention involving yoga-mindfulness.ResultsResults suggested that young children can exploit global probabilistic changes to optimize motor preparation/ inhibition while counterbalancing fatigue effects. Moreover, they successfully modulate interference control as a function of environmental contingencies, displaying more optimal conflict resolution when proactive control is engaged. Finally, we observed a post-intervention increase of the capability to implicitly adapt motor preparation/inhibition and a boosting effect on the interference control functions.DiscussionOverall, these findings confirmed that adaptive CC is already present in preschool-aged children, extending these results to include 4-years-olds. Additionally, school-based yoga-mindfulness programs are feasible and might improve children’s capability to flexibly and proactively adapt to environmental requests promoting cognitive proficiency.
Psychosocial well-being index and sick leave in the workplace: a structural equation modeling of Wittyfit data
Authors: Colin-Chevalier Rémi , Pereira Bruno , Dewavrin Samuel , Cornet Thomas , Baker Julien Steven , Dutheil Frédéric 
Published: January 2025

BackgroundPsychosocial well-being, which assesses emotional, psychological, social, and collective well-being, could help measure risk and duration of sick leave in workers.ObjectiveThis study aims to build a structural equation model of a psychosocial well-being index based on 10 psychosocial factors and investigate its association with sick leave.MethodsData of workers using Wittyfit was collected in 2018. Psychosocial factors (job satisfaction, atmosphere, recognition, work-life balance, meaning, work organization, values, workload, autonomy, and stress) were self-assessed using health-related surveys, while sick leave records were provided by volunteer companies.ResultsA total of 1,399 workers were included in the study (mean age: 39.4 ± 9.4, mean seniority: 9.2 ± 7.7, 49.8% of women, 12.0% managers). The prevalence of absenteeism was 34.5%, with an average of 8.48 ± 28.7 days of sick leave per worker. Structural equation modeling facilitated computation of workers’ psychosocial well-being index (AIC: 123,016.2, BIC: 123,231.2, RMSEA: 0.03). All factors, except workload (p = 0.9), were influential, with meaning (β = 0.72, 95% CI 0.69–0.74), values (0.69, 0.67–0.70) and job satisfaction (0.64, 0.61–0.66) being the main drivers (p &lt; 0.001). Overall, psychosocial well-being was found to be a protective factor for sick leave, with a 2% decreased risk (OR = 0.98, 95% CI 0.98–0.99, p &lt; 0.001) and duration (IRR = 0.98, 95% CI 0.97–0.99, p &lt; 0.001) per psychosocial well-being index point.ConclusionThe psychosocial well-being index provides a measure of psychosocial well-being and helps predict sick leave in the workplace. This new indicator could be used to analyze the association between psychosocial well-being and other health outcomes.Clinical trial registrationClinicaltrials.gov, identifier NCT02596737.
Association of biochemical indicators with multimorbidity in 19,624 older adult individuals with chronic diseases: a study from Jindong District, Jinhua City, China
Authors: Yao Qihuan , Chen Guozhong 
Published: January 2025

BackgroundChronic disease multimorbidity is influenced by multiple factors, but with little knowledge on the impact of biochemical indicators. This study aims to investigate the prevalence of multimorbidity of chronic diseases among older adult individuals in the community, as well as the factors related to biochemical indicators associated with chronic disease multimorbidity.MethodsThe study included 19,624 older adult individuals aged 60 and above in Jindong District, Jinhua City, Zhejiang Province, China. Participants completed a national standardized older adult health examination in the community. Chi-square tests and logistic regression were employed to evaluate the potential factors of biochemical indicators related to multimorbidity of chronic diseases.ResultsThe multimorbidity rate of chronic diseases in older adult patients is 70.3%. Each chronic disease coexists with one or more other chronic diseases in over 75% of cases. Among the biochemical indicators, hemoglobin (Hb) (OR = 1.46, 95%CI: 1.13–1.90), white blood cell count (WBC) (OR = 1.25, 95%CI: 1.02–1.54), red blood cell count (RBC) (OR = 1.36, 95%CI: 1.10–1.69), urinary protein (U-PRO) (OR = 1.10, 95%CI: 1.02–1.19), urinary glucose (U-GLU) (OR = 1.44, 95%CI: 1.23–1.67), alanine aminotransferase (ALT) (OR = 1.71, 95%CI: 1.39–2.10), aspartate aminotransferase (AST) (OR = 1.22, 95%CI: 1.05–1.41), creatinine (Cr) (OR = 1.28, 95%CI: 1.16–1.42), uric acid (UA) (OR = 1.36, 95%CI: 1.22–1.51), total cholesterol (TC) (OR = 1.76, 95%CI: 1.59–1.95), triglycerides (TG) (OR = 2.63, 95%CI: 2.46–2.82), low-density lipoprotein cholesterol (LDL-C) (OR = 1.84, 95%CI: 1.60–2.11), high-density lipoprotein cholesterol (HDL-C) (OR = 10.99, 95%CI: 8.12–14.90), and fasting blood glucose (FBG) (OR = 1.89, 95%CI: 1.74–2.05) are associated with the risk of multimorbidity of chronic diseases (p &lt; 0.05). Among these, lipid parameters demonstrated the strongest associations with multimorbidity risk, with low HDL-C showing an 11-fold increase and elevated TG a 2.63-fold increase.ConclusionThis study found that the prevalence of multimorbidity among older adult individuals in this region reached 70.3%. Multiple biochemical indicators were significantly associated with multimorbidity, particularly lipid parameters (low HDL-C and elevated TG), glucose parameters (elevated FBG and positive U-GLU), liver function (elevated ALT), and hemoglobin levels. These findings provide important evidence for research on factors associated with multimorbidity in the older adult population.
Exploring the evolution of global beef trade network patterns based on complex network analysis
Authors: Wang Qianqian , Xu Wangfang , Cheng Rongzhu 
Published: January 2025

IntroductionThe global beef trade, as a critical component of the meat trade, plays an important role in balancing beef supply and demand worldwide. However, research on the evolution of its network patterns remains relatively limited. This article aims to explore the evolution of global beef trade network patterns and provide insights into its implications for sustainable development.MethodsUsing complex network theory, this paper constructs weighted and unweighted global beef trade networks based on international trade data and conducts an in-depth analysis of the evolution of global beef trade patterns from 2013 to 2022 across the overall, individual, and clustering levels.ResultsThe analysis reveals an increasing trend in connectivity, efficiency, and tightness within the global beef trade network. In the unweighted network, the core beef-importing countries are primarily concentrated in Germany, the United Arab Emirates, and the Netherlands. However, in the weighted network, the core importing countries shift to the United States, Japan, and China. Meanwhile, the core beef-exporting countries consistently remain Australia, Brazil, and New Zealand in both network types. Additionally, the analysis identifies clustering and regionalization characteristics within the global beef trade blocks.DiscussionThese findings highlight the evolving dynamics of global beef trade, emphasizing the roles of key countries and the structural shifts in the trade network. The study provides targeted recommendations for promoting sustainable development in the beef trade sector.
Hadronic Molecules with Four Charm or Beauty Quarks
Authors: Liu Wen-Ying , Chen Hua-Xing 
Published: January 2025

We apply extended local hidden-gauge formalism to study meson–meson interactions with the quark constituents ccc¯c¯, ccc¯b¯/c¯c¯cb, ccb¯b¯/c¯c¯bb, bbc¯b¯/b¯b¯cb, and bbb¯b¯, in which the exchanged mesons are the fully heavy vector mesons J/ψ, Bc* and Υ. We solve the coupled-channel Bethe–Salpeter equation to derive two poles in the bbc¯b¯ system and two poles in the ccc¯b¯ system. There are also four charge-conjugated poles in the b¯b¯cb and c¯c¯cb systems. In the bbc¯b¯ system, one pole corresponds to a sub-threshold bound state when the cutoff momentum is set to Λ>850 MeV. The other pole in this system corresponds to a sub-threshold bound state when Λ>1100 MeV. In the ccc¯b¯ system, the two poles correspond to sub-threshold bound states only when Λ>1550 MeV and Λ>2650 MeV. This makes them difficult to identify as deeply bound hadronic molecules. We propose investigating the two poles of the bbc¯b¯ system in the μ+μ−Bc− channel at the LHC.
Современные подходы к учетно-аналитической работе по расчётам с персоналом, связанным с оплатой труда
Authors: Мельгуй А.Э. , Ковалева Н.Н. , Ермакова Л.В. 
Published: January 2025

В статье анализируются современные тенденции организации учетноаналитической работы в бухгалтерских службах экономических субъектов по расчетам с персоналом, связанным с оплатой его трудовой деятельности. Рассматриваются наиболее применяемые в отечественной хозяйственной практике формы и виды оплаты труда, а также порядок их учёта. Проводится анализ удержаний, которые можно классифицировать на определенные категории. Акцентируется внимание на некоторые проблемы учётноаналитического обеспечения расчётов с сотрудниками по заработной плате. На участке учетноаналитической работы бухгалтерского учета экономического субъекта необходимы наиболее высококвалифицированные работники, имеющие высокую профессиональную подготовку и проходящие непрерывное профессиональное обучение посредством курсов повышения квалификации. Так как сфера бухгалтерского учета подлежит жесткому нормативному регулированию, которое постоянно совершенствуется и изменяется.
The article analyzes the current trends of accounting and analytical work in the accounting services of economic entities on the calculations with personnel related to the payment of his work. The most applicable forms and types of pay, as well as the procedure of their accounting, are considered. Retentions are analyzed, which can be categorized into specific categories. The emphasis is on some of the problems of accounting and analytical provision of payments with employees on salaries. The accounting and analysis of the economic entity requires the most highly qualified workers with high professional training and ongoing vocational training through refresher courses. Because the accounting sector is subject to strict regulatory regulation, which is constantly being improved and changed.
Оптимизация системы налогообложения в организации с помощью иностранного юридического лица
Authors: Пономарев Д.М. 
Published: January 2025

Данная статья поднимает актуальные проблемы оптимизации налогообложения. Ключевая направленность оптимизации налогов заключается в уменьшении налогооблагаемой базы организации. В процессе планирования налоговой политики необходимо учитывать современные направления развития налогообложения и налогового контроля. Так же организации должны учитывать опыт партнеров или конкурентов, которые уже проиграли или выиграли споры с налоговыми инспекциями по аналогичным вопросам.
The intentional of optimization of taxes is a reduction of the tax obligations of the organization. In the process of tax policy planning it is necessary to take into account the current trends in taxation and tax control. Also, organizations should consider the experience of partners or competitors who have already lost or won disputes with tax authorities on similar issues.
Формирование информации о собственном капиталев системе управления акционерного общества
Authors: Бадрутдинова Д.И. , Снеткова Т.А. 
Published: January 2025

В условиях рыночной экономики роль системы управления формированием и эффективным использованием собственного капитала бесспорно велика, поскольку собственный капитал является одним из важнейших источников средств для существования и развития любого хозяйствующего субъекта. Информация о собственном капитале организации является особенно полезной и важной для принятия управленческих решений не только со стороны внешних пользователей (потенциальных инвесторов, настоящих собственников, кредиторов, деловых партнеров, государственных органов), но и со стороны внутренних пользователей бухгалтерской отчетности, которыми являются управленцы всех уровней управления.
In a market economy, the role of the management system for the formation and effective use of equity is undoubtedly great, since equity is one of the most important sources of funds for the existence and development of any economic entity. Information about the equity of the organization is particularly useful and important for management decisions not only by external users (potential investors, real owners, creditors, business partners, government agencies), but also by internal users of financial statements, which are managers at all levels of management.
Аллитерация в эпосе «Манас».
Authors: Алишова М.К. 
Published: January 2025

Эта статья посвящена аллитерации в эпосе Манас , ее типам и использованию в переводе. Древний век аллитерации свидетельствует о богатом наследии кыргызского народа. В кыргызском фольклоре аллитерация обогащена сказками, старинными сагами, народными песнями и особенно эпическим Манасом . Самый древний и замечательный памятник устного традиционного фольклора, который на многие годы превзошел наши дни. В Манасе отразились история, культура, традиции, борьба за мирную жизнь, борьбу за честь, за этническую идентичность и за национальное существование. Эпический Манас , шедевр мировой поэзии и энциклопедии кыргызской нации, содержит все поэтические краски, приложения и жанры. Специфическими особенностями рифм Манаса являются исключительно развитая аллитерация, преимущественно первичная или анафорическая аллитерация.
This article deals with alliteration in epic Manas, its types and usage in translation.The ancient age of alliteration witnesses a rich heritage of the Kyrgyz nation. In Kyrgyz folklore alliteration is enriched in fairytales, old sagas, folk songs and especially in epic Manas. The most ancient and remarkable monument of oral traditional folklore, that surpassed many centuries to our present day. In Manas was reflected the history, culture, traditions, struggle for peaceful life, fight for honor, for ethnic identity and for national existence. A masterpiece of world poetry and encyclopedia of the Kyrgyz nation, epic Manas contains all poetic colors, applications and genres. Specific peculiarities of Manas rhymes exceptionally developed alliteration, mainly primary or anaphoric alliteration.
Повышение экономической привлекательности территории: экологический туризм
Authors: Прохорова М.П. , Лебедева Т.Е. , Серопян Л.С. 
Published: January 2025

в работе описаны преимущества территории для развития экологического туризма. В качестве объекта исследования выбрана территория республики Карелия. Авторами выявлены конкурентные преимущества территории. Проанализированы предложения туристских продуктов в сегменте экологического туризма. Сделаны выводы о тенденции увеличения спроса на экологические продукты в республике Карелия.
Abstract: the paper describes the advantages of the territory for the development of ecological tourism. The territory of the Republic of Karelia was chosen as the object of research. The authors have identified the competitive advantages of the territory. The offers of tourism products in the segment of ecological tourism are analyzed. Conclusions are drawn about the trend of increasing demand for environmental products in the Republic of Karelia.
Разработка и внедрение новых технологий, как фактор повышения экономической эффективности производства сельскохозяйственной продукции в СПК «Ермак» Нововаршавского района Омской области
Authors: Зинич А.В. , Пакштяев И.С. 
Published: January 2025

В статье рассмотрены основные направления повышения экономической эффективности производства сельскохозяйственной продукции на основе разработки и внедрения в Ермак Нововаршавского района Омской области новых технологий.
the article considers the basic directions of increase of economic efficiency of agricultural production through the development and implementation Ermak Novovarshavskogo district of Omsk region of new technologies.
Анализ использования информационных технологийв организациях Курганской области
Authors: Бутюгина А.А. , Никулина С.Н. , Горбунова Е.Е. 
Published: January 2025

В современных условиях необходимо совершенствовать информационную систему организации. Особое внимание в статье уделяется развитию информационных и коммуникационных технологий в конкретном регионе.
In modern conditions it is necessary to improve the information system of the organization. Particular attention is paid to the development of information and communication technologies in a particular region.
Геймификация как инновационный метод управления в сфере развития персонала современной компании
Authors: Шевелева К.И. 
Published: January 2025

в статье поднимается вопрос о разработке стратегии совершенствования системы адаптации и обучения сотрудников посредством внедрения инновационного инструмента управления геймификации, которая позволяет формировать уникальный опыт сотрудников различных компаний, улучшать мотивацию и вовлеченность потребителей и сотрудников в работу, за счет чего еще будет улучшаться конкурентная среда.
the article raises the question of developing a strategy for improving the system of adaptation and training of employees through the introduction of an innovative management tool gamification, which allows to form a unique experience of employees of different companies, improve the motivation and involvement of consumers and employees in the work, due to which the competitive environment will.
Применение эко-инноваций для совершенствования деятельности современных компаний
Authors: Жаринова Д.И. , Крюкова А.А. 
Published: January 2025

в данной статье рассматривается вопрос применения экологических инноваций на предприятиях как один из инструментов повышения эффективности их деятельности. Представлены инновационные разработки, позволяющие максимально снизить загрязнение окружающей среды, обеспечить комфортные условия проживания, повысить эффективность производства. Поднимается вопрос необходимости внедрения эко-инновация для повышения уровня жизни.
this article discusses the use of environmental innovation in enterprises as one of the tools to improve the efficiency of their activities. Innovative developments are presented that allow to minimize environmental pollution, provide comfortable living conditions, increase production efficiency. The question of the need to introduce eco-innovation to improve living standards is raised.
Исследование традиционных методов анализа финансового состояния предприятия
Authors: Бубновская Т.В. , Ким Е.Ф. 
Published: January 2025

Финансовый анализ предприятия предназначается для обоснования управленческих решений в системе управления организацией. Он помогает получить объективную информацию о реальном финансовом состоянии организации, прибыльности и эффективности ее работы. Финансовое состояние организации оценивается показателями, которые характеризуют наличие, размещение и использование финансовых ресурсов. Данные показатели отражают результаты экономической деятельности организации, определяют ее конкурентоспособность, деловой потенциал, степень гарантий экономических интересов предприятия и его партнеров по финансовым отношениям.
Financial analysis of the enterprise is intended to justify management decisions in the management system of the organization. It helps to obtain objective information about the real financial condition of the organization, profitability and efficiency of its work. Indicators that characterize the availability, placement and use of financial resources assess the financial condition of the organization. These indicators reflect the results of economic activity of the organization determine its competitiveness, business potential, the degree of guarantees of economic interests of the enterprise and its partners in financial relations.