bluuebunny/crossref_metadata_2025_split huggingface dataset:
Integration of Aivazovsky's visual code into the Crimea's artistic space of the first half of the twentieth century
Authors: Shevchuk Veronika Gennadiyevna 
Published: February 2025

The legacy of Crimean painting from the late nineteenth to the first half of the twentieth centuries requires a deep scientific approach in cultural studies, as a result of which the relevance of our research is determined by the analysis of the evolution of the visual code of the great marine painter I. K. Aivazovsky, reflected in the works of Crimean artists of subsequent generations. The application of the cultural approach together with the art historical analysis made it possible to address the problem of the synthesis of traditions and innovation, to trace the transformation of the methods of depicting the Crimean nature of I. K. Aivazovsky in the works of painters during the period under study. The cultural code, in the semiotic interpretation of Yu. M. Lotman, is identified with a communicative function and is a text in the form of a special form of message transmission. Based on this provision, we have named the term "Aivazovsky code" as a pictorial text, that is, a method of depicting the Crimea used and transformed in the works of Crimean painters and masters of the Cimmerian school, whose work is the object of our research. The subject of the study is the evolution of the Aivazovsky code, integrated into the art of the Crimean school of the first half of the twentieth century, in the context of creating an artistic image of Crimea. The research methodology includes the use of a cultural approach in conjunction with art historical analysis and the method of comparison, which makes it possible to address the problem of synthesizing traditions and innovation, to trace the integration and transformation of methods of depicting the Crimean nature of I. K. Aivazovsky in the works of painters during the period under study. A special contribution to the study of the stated topic is the characterization of Aivazovsky's visual code and the identification of its features transformed in the process of integration into the artistic space of the Crimean painters of the first half of the twentieth century. The novelty of the research lies in explanation of the term "Aivazovsky code" and conducting a cultural analysis of this phenomenon. It is established that Aivazovsky's visual code, as a carrier of information, in the process of integration determines the possibility of dialogue and communication between cultural spaces of artists. Throughout the twentieth century, the process of evolution of Crimean painting has been taking place based on the use of a synthesis of traditions and innovation, thanks to the introduction of new visual texts by artists into the cultural memory embedded in the Aivazovsky code. A feature of his evolution is the transition from romanticism and realism to the transformation of the artistic image.
Comparative Study on Antimicrobial and Phytochemical Properties of Different Polar Fractions of Anogeisuss leiocarpus Root Extract from Langtang L.G.A. Plateau State
Authors: Eke Uche. B. , Sunday. Elaigwu , S.J.I. Ibejekwe, , Agada Godwin , Bulus Denji Kitka , Gomerep Bakji 
Published: February 2025

Anogeissus leiocarpus plant is widely used in Africa and among Tarok people in the northern senatorial zone of Plateau State, Nigeria as antimicrobial agents against many pathogenic microorganisms. This study was carried out invitro to compare the antibacterial and antifungal properties of non-polar (hexane, ethyl acetate) and polar (methanol, water) root extracts against Staphylococcus aureus, (ATCC 6538), Klebsiella pneumonia,(ATCC 1705), Escherichia coli, (ATCC 25922), Salmonella typhi (clinical isolates) Aspergillus flavus (clinical isolates), Trichophyton rubrum (clinical isolates), Aspergillus braziliensis (clinical isolates), Bacillus subtilis (ATCC 6633) and Candida albicans (ATCC 10231). The extracts of polar solvents showed strong antibacterial activity against Staphylococcus aureus, Klebsiella pneumonia, Salmonella typhi, Escherichia coli, and Candida albicans. But for Aspergillus flavus, and Trichophyton rubrum both the polar and non-polar solvents showed equal inhibition. Ciprofloxacin, Fluconazole and Amphotericin B were used as control. The result revealed that the selected micro-organisms were sensitive within the concentration range of 50 – 400mg/ml. Preliminary phytochemical results revelled the presence of important bioactive substances such as cardiac glycosides, tannins, saponins, steroids, carbohydrates, flavonoids and terpenes. Thus, methanol extracts contain bioactive compounds that could be utilized in developing new antibiotics.
Influence of Different Levels Organic and Inorganic Fertilizer Growth and Yield of Potato (Solanum tuberosum L.)
Authors: Linda Raju , David Arun Alfred , Thomas Tarence 
Published: February 2025

The global food demand of growing human population and need for eco-friendly strategy for sustainable soil-plant-microbes-environmental system currently a crucial challenge. In conventional farming for increasing the crop yield farmers are using huge amount of chemical fertilizer in the fields. Due to either over or imbalance use of chemical fertilizers in cultivation of crops, degraded the soil fertility and health of soil. Such farming is blamed for land degradation and environment pollution and adversely affecting the human health, plants and animals. Soil degradation contributes to low agricultural productivity. Organic amendments (OAs) have the potentials to reverse soil degradation processes by improving the soil's physical and chemical properties and consequently improve crop growth and yield performance An experiment was carried out during the winter season of 2021- 2022 to know the Effect of different levels of Vermicompost,Neam cake and fertilizer on soil health and yield of Potato (Solanum tuberosum L.) ”. The experiment was laid out in Randomised Block Design (RBD) with three replicates for each treatment. The fertilizer applied for the crop was NPK and @ 120kg, ha-1, 80kg ha-1, 100 kgha-1, Vermicompost 6 and Neem cake 1.2 t h-1, respectively, showed significant influence on the soil health of Potato . Based on the above research work, it is concluded that application of Vermicompost, Neam cake and fertilizer, treatment T9 [NPK 100% + VC @100% + Neem Cake @ 100% ha-1] was found more beneficial and significantly improved soil, and tuber yield of Potato grown under Allahabad Agro-climatic conditions.
Synthesis and Biological Evaluations of Prop-2-enone and Penta-1, 4-dien-3-one Chalcones and their Hydrazone Derivatives
Authors: Ekolama Bill , Miediegha Oyeintonbara , Eboh Abraham Sisein , Tabowei Victory , Bunu Samuel , Ere Diepreye 
Published: February 2025

Chalcones are naturally coloured compounds found in plants, characterized by a distinctive chemical structure with two aromatic rings linked by a three-carbon α, β-unsaturated carbonyl bridge. Chalcones synthesis was achieved via modified Claisen-Schmidt condensation utilizing aromatic aldehydes and ketones, giving a yield of 80 – 98 % and was then combined with 2, 4-dinitrophenyl hydrazine (2, 4-DNPH) to form hydrazones yielding 58 – 86 %. Products formed were characterized accordingly using 1H-NMR, FTIR, UV, and elemental analysis. The biochemical assay involving antimicrobial activity by employing the agar well diffusion method indicated that the chalcones exhibited no activity against the selected isolates (E. coli, S. aureus, P. aeruginosa, and B. subtilis), while the compounds showed good analgesic properties as well as good antioxidant properties as indicated in the DPPH radical scavenging assay with one of the products BE6 showing (IC50=11.68 µM) and the Nitric Oxide bioavailability of BE1A indicating high activity. The total antioxidant determination indicated that the chalcones were better than the hydrazones with BE7 giving a value of TAC=8724.02. This indicates that coupled chalcones may exhibit good analgesic and antioxidant properties but still not a good antimicrobial properties.
Sex or Gender Reporting in Ophthalmology Clinical Trials Among US Food and Drug Administration Approvals, 1995 to 2022
Authors: Xie Jim Shenchu , Kaur Hargun , Tao Brendan , Lee Jordon , Solish Danielle , Kohly Radha , Margolin Edward 
Published: January 2024

ImportanceAs critical determinants of scientific rigor, reproducibility, and equity, sex and gender should be considered in clinical trial design and reporting.ObjectiveTo evaluate the accuracy of sex and gender reporting and extent of sex- and gender-based analysis in clinical trials associated with US Food and Drug Administration (FDA) drug approvals between January 1, 1995, and December 31, 2022.Design, Setting, and ParticipantsIn this cross-sectional study of participants enrolled in FDA ophthalmology trials, the following trial documents were reviewed by pairs of independent reviewers in decreasing order of priority: peer-reviewed publication, ClinicalTrials.gov report, and FDA medical and statistical reviews. Trial protocols and supplementary materials were also reviewed.Main Outcome and MeasuresThe proportion of trials that correctly applied sex and gender terminology, reported the method of assessing sex or gender, and conducted sex- or gender-based data analysis; incorrect application of sex and gender terminology was defined as interchangeable use of sex- and gender-related terms without a clear justification.ResultsBetween 1995 and 2022, 34 ophthalmic drugs corresponding to 85 trials (34 740 participants) received FDA approval, of which 16 drugs (47.1%) corresponding to 32 trials (18 535 participants [37.6%]) were associated with peer-reviewed publications. Sixteen trials used sex and gender terminology correctly (19.5%). No trial reported how sex and gender were collected nor enrolled participants from sexual and gender identity minority populations. Most trials reported sex- and gender-disaggregated demographic data (96.5%), but few conducted sex- or gender-based analysis for data on dropout (1.2%), primary outcomes (28.2%), secondary outcomes (2.4%), and adverse events (9.4%). Erroneous sex and gender reporting was associated with later publication year (2008.5 vs 2001.0; median difference, 7.5; 95% CI, −6.0 to 11.0; P &amp;lt; .001) and higher journal influence metrics, including 2022 journal impact factor (13.7 vs 5.9; median difference, 7.8; 95% CI, −1.4 to 152.4, P &amp;lt; .001) and 2022 journal citation indicator (4.9 vs 2.1; median difference, 2.9; 95% CI, 0-20.0, P &amp;lt; .001).Conclusions and RelevanceIn this observational study, over three-quarters of ophthalmology trials associated with FDA drug approvals conflated sex and gender and over two-thirds lacked sex- and gender-based analyses. More rigorous integration of sex and gender appears warranted for FDA, and presumably other trials, to improve their validity, reproducibility, and equity.
Resting‐state fMRI functional connectome of C9orf72 mutation status
Authors: Stanziano Mario , Fedeli Davide , Manera Umberto , Ferraro Stefania , Medina Carrion Jean P. , Palermo Sara , Sciortino Paola , Cogoni Maurizio , Agosta Federica , Basaia Silvia , Filippi Massimo , Grisoli Marina , Valentini Maria C. , De Mattei Filippo , Canosa Antonio , Calvo Andrea , Bruzzone Maria G. , Chiò Adriano , Nigri Anna , Moglia Cristina 
Published: January 2024

AbstractObjectiveThe resting‐state functional connectome has not been extensively investigated in amyotrophic lateral sclerosis (ALS) spectrum disease, in particular in relationship with patients' genetic status.MethodsHere we studied the network‐to‐network connectivity of 19 ALS patients carrying the C9orf72 hexanucleotide repeat expansion (C9orf72+), 19 ALS patients not affected by C9orf72 mutation (C9orf72−), and 19 ALS‐mimic patients (ALSm) well‐matched for demographic and clinical variables.ResultsWhen compared with ALSm, we observed greater connectivity of the default mode and frontoparietal networks with the visual network for C9orf72+ patients (P = 0.001). Moreover, the whole‐connectome showed greater node degree (P < 0.001), while sensorimotor cortices resulted isolated in C9orf72+.InterpretationOur results suggest a crucial involvement of extra‐motor functions in ALS spectrum disease. In particular, alterations of the visual cortex may have a pathogenic role in C9orf72‐related ALS. The prominent feature of these patients would be increased visual system connectivity with the networks responsible of the functional balance between internal and external attention.
Improved maximum correntropy cubature Kalman and information filters with application to target tracking under non‐Gaussian noise
Authors: Lu Tao , Zhou Weidong , Tong Shun 
Published: January 2024

SummaryThe cubature Kalman filter (CKF) based on the maximum correntropy criterion (MCC) has been widely used in the target tracking. However, numerical problems usually occur when there are outliers in the measurement noise. In order to solve the problems of state estimation under the non‐Gaussian measurement noise, a new combined cost function is defined based on the weighted least squares (WLS) method and MCC. In addition, a new method is also used to adaptively adjust the kernel size, then the improved maximum correntropy CKF (PMCCKF) and its corresponding improved maximum correntropy cubature information filter (PMCCIF) are proposed. Compared with the existing algorithms, the new method can not only obtain similar or even better estimation performance, but also avoid numerical problems. Moreover, when the kernel size is infinite, the performance of proposed algorithms will reduce to the standard CKF and corresponding cubature information filter (CIF) respectively, but the classical maximum correntropy CIF (MCCIF) will not, and even the performance is poor in this case. The advantages of the proposed algorithms are verified by four classical nonlinear models.
SnF2‐Induced Multifunctional Interface‐Stabilized Li5.5PS4.5Cl1.5‐Based All‐Solid‐State Lithium Metal Batteries
Authors: Wei Chaochao , Liu Chen , Xiao Yujie , Wu Zhongkai , Luo Qiyue , Jiang Ziling , Wang Zhenyu , Zhang Long , Cheng Shijie , Yu Chuang 
Published: January 2024

AbstractCompared to traditional lithium‐ion batteries with liquid electrolytes, all‐solid‐state lithium batteries have attracted extensive attention due to their heightened safety and energy density. Lithium argyrodite materials are promising solid electrolytes (SE) due to their high ionic conductivity, low grain boundary resistance, and favorable mechanical properties. However, the poor chemical/electrochemical stability of lithium argyrodite electrolytes toward the bare lithium metal anode inhibits their applications in all‐solid‐state lithium metal batteries (ASSLMBs). Here, Li‐SnF2 composite anodeswas used to induce the formation of solid electrolyte interphase (SEI) composed of LiCl, LiF, and Li22Sn5 at the Li/SE interface. The high interface energy barriers for LiF and LiCl induces the uniform deposition of lithium ions, thus hindering the growth of lithium dendrites. Meanwhile, the fast Li‐ion diffusion coefficient of the Li22Sn5 alloy accelerates Li‐ion migration across the interface section. The symmetrical cell exhibits stable cycling performance over long durations over 300 h at 0.5 mA cm−2. Moreover, the LiNbO3@NCM712/Li5.5PS4.5Cl1.5/Li‐10%SnF2 battery delivers a high initial discharge capacity of 170.9 mAh g−1 at 0.1C and retains 72.9% of its original capacity after 500 cycles at 0.5C. The facial approach for Li‐SnF2 composite anode enables the production of ASSLMBs with superior electrochemical performance.
The Nanoplasmonic Purcell Effect in Ultrafast and High‐Light‐Yield Perovskite Scintillators
Authors: Ye Wenzheng , Yong Zhihua , Go Michael , Kowal Dominik , Maddalena Francesco , Tjahjana Liliana , Wang Hong , Arramel Arramel , Dujardin Christophe , Birowosuto Muhammad Danang , Wong Liang Jie 
Published: January 2024

AbstractThe development of X‐ray scintillators with ultrahigh light yields and ultrafast response times is a long sought‐after goal. In this work, a fundamental mechanism that pushes the frontiers of ultrafast X‐ray scintillator performance is theoretically predicted and experimentally demonstrated: the use of nanoscale‐confined surface plasmon polariton modes to tailor the scintillator response time via the Purcell effect. By incorporating nanoplasmonic materials in scintillator devices, this work predicts over tenfold enhancement in decay rate and 38% reduction in time resolution even with only a simple planar design. The nanoplasmonic Purcell effect is experimentally demonstrated using perovskite scintillators, enhancing the light yield by over 120% to 88 ± 11 ph/keV, and the decay rate by over 60% to 2.0 ± 0.2 ns for the average decay time, and 0.7 ± 0.1 ns for the ultrafast decay component, in good agreement with the predictions of our theoretical framework. Proof‐of‐concept X‐ray imaging experiments are performed using nanoplasmonic scintillators, demonstrating 182% enhancement in the modulation transfer function at four line pairs per millimeter spatial frequency. This work highlights the enormous potential of nanoplasmonics in optimizing ultrafast scintillator devices for applications including time‐of‐flight X‐ray imaging and photon‐counting computed tomography.
Robust, Sprayable, and Multifunctional Hydrogel Coating through a Polycation Reinforced (PCR) Surface Bridging Strategy
Authors: Wang Jing , Li Xin‐Yi , Qian Hong‐Lin , Wang Xing‐Wang , Wang You‐Xiang , Ren Ke‐Feng , Ji Jian 
Published: January 2024

AbstractThe sprayable hydrogel coatings that can establish robust adhesion onto diverse materials and devices hold enormous potential; however, a significant challenge persists due to monomer hydration, which impedes even coverage during spraying and induces inadequate adhesion post‐gelation. Herein, a polycation‐reinforced (PCR) surface bridging strategy is presented to achieve tough and sprayable hydrogel coatings onto diverse materials. The polycations offer superior wettability and instant electrostatic interactions with plasma‐treated substrates, facilitating an effective spraying application. This PCR‐based hydrogel coatings demonstrate tough adhesion performance to inert PTFE and silicone, including remarkable shear strength (161 ± 49 kPa for PTFE), interfacial toughness (198 ± 27 J m−2 for PTFE), and notable tolerance to cyclic tension (10 000 cycles, 200% strain, silicone). Meanwhile, this method can be applied to various hydrogel formulations, offering diverse functionalities, including underwater adhesion, lubrication, and drug delivery. Furthermore, the PCR concept enables the conformal construction of durable hydrogel coatings onto sophisticated medical devices like cardiovascular stents. Given its simplicity and adaptability, this approach paves an avenue for incorporating hydrogels onto solid surfaces and potentially promotes untapped applications.
Metabolic Bypass Rescues Aberrant S‐nitrosylation‐Induced TCA Cycle Inhibition and Synapse Loss in Alzheimer's Disease Human Neurons
Authors: Andreyev Alexander Y. , Yang Hongmei , Doulias Paschalis‐Thomas , Dolatabadi Nima , Zhang Xu , Luevanos Melissa , Blanco Mayra , Baal Christine , Putra Ivan , Nakamura Tomohiro , Ischiropoulos Harry , Tannenbaum Steven R. , Lipton Stuart A. 
Published: January 2024

AbstractIn Alzheimer's disease (AD), dysfunctional mitochondrial metabolism is associated with synaptic loss, the major pathological correlate of cognitive decline. Mechanistic insight for this relationship, however, is still lacking. Here, comparing isogenic wild‐type and AD mutant human induced pluripotent stem cell (hiPSC)‐derived cerebrocortical neurons (hiN), evidence is found for compromised mitochondrial energy in AD using the Seahorse platform to analyze glycolysis and oxidative phosphorylation (OXPHOS). Isotope‐labeled metabolic flux experiments revealed a major block in activity in the tricarboxylic acid (TCA) cycle at the α‐ketoglutarate dehydrogenase (αKGDH)/succinyl coenzyme‐A synthetase step, metabolizing α‐ketoglutarate to succinate. Associated with this block, aberrant protein S‐nitrosylation of αKGDH subunits inhibited their enzyme function. This aberrant S‐nitrosylation is documented not only in AD‐hiN but also in postmortem human AD brains versus controls, as assessed by two separate unbiased mass spectrometry platforms using both SNOTRAP identification of S‐nitrosothiols and chemoselective‐enrichment of S‐nitrosoproteins. Treatment with dimethyl succinate, a cell‐permeable derivative of a TCA substrate downstream to the block, resulted in partial rescue of mitochondrial bioenergetic function as well as reversal of synapse loss in AD‐hiN. These findings have therapeutic implications that rescue of mitochondrial energy metabolism can ameliorate synaptic loss in hiPSC‐based models of AD.
Product Peroxidation Inhibition in Methane Photooxidation into Methanol
Authors: Cao Yuehan , Huang Zeai , Han Chunqiu , Zhou Ying 
Published: January 2024

AbstractMethane photooxidation into methanol offers a practical approach for the generation of high‐value chemicals and the efficient storage of solar energy. However, the propensity for C─H bonds in the desired products to cleave more easily than those in methane molecules results in a continuous dehydrogenation process, inevitably leading to methanol peroxidation. Consequently, inhibiting methanol peroxidation is perceived as one of the most formidable challenges in the field of direct conversion of methane to methanol. This review offers a thorough overview of the typical mechanisms involved radical mechanism and active site mechanism and the regulatory methods employed to inhibit product peroxidation in methane photooxidation. Additionally, several perspectives on the future research direction of this crucial field are proposed.
Ferroptosis in Osteocytes as a Target for Protection Against Postmenopausal Osteoporosis
Authors: Jiang Zengxin , Qi Guobin , He Xuecheng , Yu Yifan , Cao Yuting , Zhang Changqing , Zou Weiguo , Yuan Hengfeng 
Published: January 2024

AbstractFerroptosis is a necrotic form of iron‐dependent regulatory cell death. Estrogen withdrawal can interfere with iron metabolism, which is responsible for the pathogenesis of postmenopausal osteoporosis (PMOP). Here, it is demonstrated that estrogen withdrawal induces iron accumulation in the skeleton and the ferroptosis of osteocytes, leading to reduced bone mineral density. Furthermore, the facilitatory effect of ferroptosis of osteocytes is verified in the occurrence and development of postmenopausal osteoporosis is associated with over activated osteoclastogenesis using a direct osteocyte/osteoclast coculture system and glutathione peroxidase 4 (GPX4) knockout ovariectomized mice. In addition, the nuclear factor erythroid derived 2‐related factor‐2 (Nrf2) signaling pathway is confirmed to be a crucial factor in the ferroptosis of osteocytic cells. Nrf2 regulates the expression of nuclear factor kappa‐B ligand (RANKL) by regulating the DNA methylation level of the RANKL promoter mediated by DNA methyltransferase 3a (Dnmt3a), which is as an important mechanism in osteocytic ferroptosis‐mediated osteoclastogenesis. Taken together, this data suggests that osteocytic ferroptosis is involved in PMOP and can be targeted to tune bone homeostasis.