bluuebunny/crossref_metadata_2025_split huggingface dataset:
Can physicians and schools mitigate social inequalities in human papillomavirus vaccine awareness, uptake and vaccination intention among adolescents? A cross-sectional study, France, 2021 to 2022
Authors: Moffroid Hadrien , Doglioni Damien Oudin , Chyderiotis Sandra , Sicsic Jonathan , Barret Anne-Sophie , Raude Jocelyn , Bruel Sebastien , Gauchet Aurelie , Michel Morgane , Gagneux-Brunon Amandine , Thilly Nathalie , Mueller Judith E ,   on behalf of the PrevHPV Consortium
Published: November 2023

Background
In France, human papillomavirus (HPV) vaccination coverage varies across socioeconomic levels.

Aim
We aimed at assessing HPV vaccine awareness, uptake and vaccination intention among adolescents in France.

Methods
In a cluster-randomised study, 13–15-year-old students in 61 French middle schools completed a web-based questionnaire. We used multivariable logistic regression to evaluate determinants of HPV vaccine awareness, self-reported uptake and vaccination intention among unvaccinated students and interaction terms to explore effects of visits to family physician and remembering school lessons on vaccination. The French deprivation index of school municipalities served as proxy for socioeconomic levels.

Results
Among 6,992 participants, awareness was significantly associated with parental education (odds ratio (OR) = 0.82; 95% confidence interval (CI): 0.71–0.95), language spoken at home (OR = 0.59; 95% CI: 0.52–0.66) and deprivation level (OR = 0.57; 95% CI: 0.44–0.71), regardless of physician visit or school lessons. Vaccine uptake was associated with parental education without a recent physician visit (OR = 0.31; 95% CI: 0.16–0.59, vs OR = 0.64; 95% CI: 0.52–0.78 with a visit, interaction p = 0.045). Vaccination intention among unvaccinated was associated with deprivation level (moderate-low vs low) among students not remembering school lessons on vaccination (OR = 0.17; 95% CI: 0.05-0.62, vs OR = 0.93; 95% CI: 0.51–1.67 remembering school lessons, interaction p = 0.022). Parental education was associated with vaccination intention among students reporting a physician visit (OR = 0.41; 95% CI: 0.26–0.64 vs OR = 1.05; 95% CI: 0.50–2.20 without a visit, interaction p = 0.034).

Conclusion
Our results suggest that healthcare and school could promote vaccination and mitigate social inequalities in HPV vaccination coverage.
Gangguan Ansietas pada Penderita Hipetiroid
Authors: Zulaikha Afrina , Siregar Chataya Syah Dhafa 
Published: November 2023

Ansietas diartikan sebagai rasa takut, terhadap objek yang bersifat nyata ataupun tidak ditandai dengan bentuk emosi tidak menyenangkan, kekhawatiran, keprihatinan, mudah tersinggung, tidak tenang, dan gangguan tidur. Penyebab ansietas ialah terjadinya kesalahan pada neurotransmiter yang berperan dalam mekanisme gangguan ansietas seperti norepinefrin, serotonin, dopamin, dan asam gamma-aminobutirat (GABA) yang berfungsi dalam respons tubuh terhadap stres. Salah satu etiologi dari ansietas adalah dipengaruhi oleh gangguan medis umum. Ternyata banyak gangguan medis umum yang dikaitkan dengan ansietas. Gejala yang timbul seperti gemetar, berkeringat, jantung berdebar, kepala terasa pusing, ketegangan otot, mual, sulit bernafas, baal, diare, gelisah, kekhawatiran, dan panik. Hal ini disebabkan efek fisiologis langsung secara medis. Gangguan medis umum yang sering dikaitkan dengan ansietas salah satunya adalah hipertiroid. Penelitian yang dilakukan pada pasien hipertiroid menunjukkan 41.67% dari subjek mengalami kecemasan dengan gejala insomnia, mudah tersinggung, merasa sedih, dan merasa tidak tenang. Hubungan gangguan ansietas pada penderita hipertiroid terjadi akibat gangguan sintesis hormon tiroid yang berlebihan sehingga menurunnya fungsi neurotransmiter GABA yang berperan dalam menekan terjadinya kecemasan. Sehingga ketika gangguan medis umum dikombinasikan dengan gangguan kecemasan, maka akan berdampak menimbulkan morbiditas dan mortalitas yang lebih besar.
Leukokoria Okuli Sinistra Ec Suspek Retinoblastoma pada Bayi Usia 54 Hari
Authors: Faizah Siti , Imelda Eva , Samira Cut Putri 
Published: November 2023

Retinoblastoma (RB) adalah tumor ganas primer pada bola mata yang paling sering terjadi pada anak. Frekuensi terjadinya RB 1:14.000-20.000 kelahiran hidup, berbeda di setiap negara. Dilaporkan angka kejadian tumor RB di negara maju lebih rendah dibandingkan di negara berkembang. Tidak ditemukan predileksi pada jenis kelamin maupun ras, dan diagnosis RB 90% pada usia < 3 tahun. Umur rata-rata terkena RB tergantung pada riwayat RB di keluarga dan sisi yang terkena. Paien seorang bayi laki-laki berusia 54 hari datang dibawa oleh kedua orang tuanya ke poli klinik Mata RSUD Dr. Zainoel Abidin dengan keluhan utama tampak bintik putih pada mata kiri. Menurut keterangan orang tua pasien, bintik putih pada mata kiri tersebut baru disadari oleh kedua orang tuanya pada saat pasien berumur 15 hari setelah lahir dan terlihat bersinar seperti mata kucing bila terkena cahaya. Pada pasien ini didapatkan pemeriksaan oculi sinistra, blink reflex (+), leukokoria (+), diameter pupil 5 mm (+), tidak respon terhadap refleks cahaya. Pada pemeriksaan B Scan USG mata kiri tampak adanya kalsifikasi di vitreus (+). Secara umum belum ada terapi definitif untuk menangani retinoblastoma, dikarenakan sifat dari penyakit ini yang sangat kompleks dan biasanya diperlukan berbagai kombinasi terapi untuk mendapatkan hasil yang baik.Deteksi dini yang dilanjutkan dengan penanganan yang cepat dan tepat dapat mengurangi mortalitas serta memperbaiki harapan hidup anak penderita retinoblastoma.
The artistic nature in the 14th and 15th books of Galen’s <em>On the Usefulness of the Parts of the Body</em>
Authors: Falcato Joana 
Published: November 2023

In the 14th and 15th books of the galenic work On the Usefulness of the Parts of the Body, dedicated to male and female reproductive organs and foetal development, the author presents nature (φύσις), the agent of the human body’s formation, as artistic and admirable, because it used an art (τέχνη) to make immortality possible, which consists in replacing one living being by another in an admirable way. Such an art is also related to a divine purpose, once nature’s action, possessing an intrinsic ability, is that of a demiurge. So, if, on the one hand, we have an artistic and practical nature, whose activity is proved by dissection and visible in the position and function of male and female reproductive organs, on the other, we have an abstract concept of the same nature, working to perpetuate humankind, but whose deepest and more abstract problems are not to be discovered nor solved in medical works such as On the Usefulness of the Parts of the Body.
In this paper I will analyse how the concepts of φύσις and τέχνη relate to each other, by developing and deepening the role of nature as an artisan regarding the formation and function of the reproductive system and foetal development and its limits as such, pointing also the different subtleties of the concept.
Biometric Characteristics of Live Weight in Reindeer Populations of the Eastern Arctic and Subarctic
Authors: Bryzgalov G. , Ignatovich L. 
Published: November 2023

Purpose: the study of biometric data on live weight and their significance for artificial selection in the population of the northern deer (Rangifertarandus L.) ..Materials and methods. Information was used from annual reports of reindeer herding of the North of the Far East. The methods of variation statistics that are generally accepted in zootechnical research were applied. Extreme (LIM) and average values (M) of the sign, trust boundaries of the general average (M ± t ∙ m), the average square deviation (σ), the coefficient of variation (CV), the boundaries of the extreme class variation (M ± 2σ) are determined. Associations of a live mass of sexual age groups in the population of the northern deer were established by calculating the correlation coefficients (R) and rectilinear regression (B).Results. The consolidated correlation coefficient (RSV), reflecting the level of direct linear connection of the live weight of calves with a mass of uterus and manufacturers, was ≈ 0.7, which relates to the degree of close dependence. Using the regression equation (y = a+bx) calculated the predicted average size of the live weight of young animals in the average live weight of the importance. The data allow you to establish the threshold of selection of tribal animals in order to obtain offspring with a given value of the sign. In the study, the impact on the live mass of the season, year, range, and farms is leveled. It was established that throughout the generations a living mass is a stable phenotypic sign. Biometric data on live weight, as a quantitative attitude, indirectly reflect the state and movement of group genetic information in the populations of deer of the Far North-East of Russia.
Obtaining a culture of somatic cells using tissue material from the ear of dead sheep/snow sheep hybrid
Authors: Shedova E. , Tsyndrina E. 
Published: November 2023

Production and cryopreservation of somatic cells (SCs) from valuable and endangered animals allows a preservation of genetic diversity and ensuring their future reproduction. The aim of present work was to isolate SCs from the ear of unique hybrid sheep (Ovis aries) and snow sheep (Ovis nivicola borealis) post-mortem. In this purpose, enzymatic and mechanical methods of tissue preparation were compared.Materials and Methods. Ears from deceased animal were brought to the laboratory 12 hours after the death in a pasture, and biological material was thoroughly washed under running water. The hairs were removed from the part of the ear shell by the blade. Skin fragments were treated with 70% ethyl alcohol, washed three times in a saline solution with antibiotics and ground up to small pieces. The ear pieces were washed several times in phosphate buffer saline and divided into two parts. One part of the explants started in vitro culture without enzymatic treatment (group 1), whereas another part was pre-treated with a 0.25% trypsin/EDTA solution. After trypsinization, either tissue fragments (group 2), or cell complexes separated from cell suspension fraction (group 3) were taken for in vitro culture for 9 days. Monitoring of cell colony formation and growth was carried out daily. Results. In the group 3, cell colonies were formed on the second day of in vitro culture. In groups 1 and 2, cell growth was observed from tissue fragments after five days regardless of the treatment. On the 9th day, all the groups produced the primary cultures, represented by two types of SCs. In general, single cell complexes from the group 3 formed cell growth zones more quickly than tissue explants from the groups 1 and 2, however, final cultures of SCs and their morphological aspects were no different between the groups. Conclusion. Methodological protocols were proposed and successfully used to obtain in vitro cultures of SCs from the ear of dead sheep/snow sheep hybrid animal, 12 hours post-mortem that may allow further storage of valuable genetic material.
Factors affecting chicken bone strength
Authors: Azovtseva A. , Dementieva N. 
Published: November 2023

Purpose: to study the accumulated data on the genetic determinism of the Kostyak fortress and discuss the possibility of their use to improve poultry farming.In both meat-type and egg-type poultry, bone strength is an important characteristic of animal welfare, on which largely depends the economic efficiency. The lack of strength is expressed by bone fragility, deformations or fractures occurring both at certain technologies of animal housing and at processing of poultry products, which is accompanied by economic losses. The quality and strength of bone tissue is formed, in addition to housing conditions, by a complex set of interactions of structural, physiological, nutritional and architectural components. The study of poultry bone strength is also complicated by reproduction peculiarities. Egg laying determines some features of osteogenesis, including medullary bone formation, which deposit calcium for eggshell formation. To date, the actual assessment of bone strength occurs postmortem, by measuring bone mineral density and breaking strength. Both methods do not allow using the evaluated animals in breeding to improve bone strength, therefore the study of genetic determinants of this trait is a relevant research task. The use of modern information analysis based on DNA technologies is a necessary step for identification of candidate genes controlling bone strength, because of their ability to increase selection efficiency in poultry. This review discusses the available results of genome-wide association studies (GWAS) for bone strength in birds, as well as existing data on the relationship of bone strength with traits such as egg production and age at first lay.
Morphometric and immuno-biochemical markers of placenta in patients with uterine eclampsia
Authors: Bulatov R. , Avdeenko V. 
Published: November 2023

Purpose: to study the segmentation of organometric and immuno-biochemical digital indicators in ewes with ESO at the end of gestation.Materials and methods. The experiment involved three flocks of Tsygai, Volgograd and Stavropol breeds, each with 700 suyag sheep. Placental tissue samples were taken from clinically healthy and sick pregnant ewes, which were placed in 10% neutral formalin. Using a Cytadel 2000 histoprocessor (Shendon), the obtained samples were clarified in chloroform and enclosed in a Histomix paraffin medium (Biovitrum). Histosections were prepared on a rotary microtome (MICROM HM340E). Using the AxioScope.A1 (ZEISS) microscope, histopreparations were photographed and processed using the ZENpro 2012 (ZEISS) program. According to Schmidt and Thannhauser, the RNA content was determined using a two-wave spectrophotometer in UV. The activity of the G-6-Phase was studied by Swanson. In vacuum tubes Vacuette ™ (Austria), blood samples were taken in the morning before feeding, from the jugular vein. Results. In sheep with eclampsia, a decrease in the total mass of the placenta, its cotiledons, as well as an increase in the length of the umbilical cord, in which stroma sclerosis is noted in the vascular wall, was observed. Small calcification foci were found in the tissues of the afterbirth, and small terminal villi are located around the stem villi near the vascular membrane, tightly adjacent to them. The proportion of syncytiotrophoblast of crypts of carbuncles and villi of the chorion of cotyledons of mature syncytium decreases in comparison with physiologically occurring severity. The content of RNA in its subcellular fractions is mainly concentrated in the microsomal fraction, 18% - in mitochondria and 7% - in the nuclear fraction. Albumins in pregnant ewes with eclampsia were reduced by 1.35 times. BASC and phagocytic activity of leukocytes in queens with eclampsia of pregnant sheep is reduced 15 days before lambing, which poses a threat to the reproductive health of the mother and the viability of newborn lambs.
Use of jiu-jitsu tools in healthy fitness directions with primary and second mature women
Authors: Golenkova Yuliia , Isichko Hanna 
Published: November 2023

The work examines the influence of the health-improving direction of fitness with elements of jiu-jitsu on indicators of physical fitness and on functional indicators of women of the first and second mature age, with the help of a developed set of exercises. The purpose is to experimentally prove the effectiveness of using jiu-jitsu elements in health-related fitness areas with elements of martial arts with women of the first and second mature age.
The research was conducted based on the Foxschool Sports Club, Kharkiv. Two groups (control - CG, and experimental - EG), 10 women in each, aged 25-50, participated in the study. Training was held three times a week, lasting 60 minutes. The results of tests on physical fitness and functional state before the experiment revealed that there are no significant differences in the condition of women, that is, the groups are identical. The results of testing after the experiment showed an improvement in the indicators of CG women, compared to the initial ones, but they turned out to be reliable only for three indicators out of nine. Instead, the results of the final tests in EG showed an improvement in many indicators, compared to the initial ones. Seven indicators out of nine turned out to be reliable. To confirm the effectiveness of the complex with jiu-jitsu elements, we used calculations using mathematical statistics, namely the calculation of Student's t-criterion.
It was found that the proposed set of exercises has a positive effect on the physical and functional condition of women. According to the obtained results, there was a tendency to increase the average indicators of physical and functional condition in the studied groups.
Approbation of the program of formation of parents' readiness to organize the system of physical development of preschoolers in the conditions of martial law
Authors: Zamrozevych-Shadrina Svitlana , Khatsaiuk Oxana , Tytovych Andrii , Holovchenko Oleksii , Hazaiev Valerii , Mahula Oleksandr 
Published: November 2023

In the process of research and analytical work by the members of the research group, it was established that insufficient number of scientific papers are devoted to the urgent issue of forming the readiness of parents to organize activities for the comprehensive, harmonious and physical development of preschoolers in the conditions of martial law. This emphasizes the relevance, timeliness and practical component of the chosen direction of scientific research. In turn, the developed competencies of parents of preschoolers in the future will ensure a high-quality and effective organization of the system of physical development of children of the studied category in accordance with modern scientific concepts of comprehensive and harmonious personality development.
The main goal of the study is the adjustment and approval of the experimental program for the formation of the readiness of parents to organize the system of physical development of preschoolers in the conditions of martial law. Research methods: abstraction, analysis and synthesis, induction and deduction, modeling, mathematical and statistical (correlation analysis, factor analysis, scaling).
As a result of the empirical study, the members of the research group adjusted and approved the experimental program for the formation of parents' readiness to organize the system of physical development of preschoolers in the conditions of martial law. Prospects for further research in the chosen direction of scientific intelligence include the development of a program of physical and harmonious development of junior schoolchildren under martial law.
Apomorphine Sublingual Film Compared with Subcutaneous Apomorphine for OFF Episodes in Parkinson’s Disease: An Open-Label, Randomized, Crossover Study
Authors: Stocchi Fabrizio , Rascol Olivier , Poewe Werner , Chaudhuri K. Ray , Kassubek Jan , Lopez Manzanares Lydia , Zhang Yi , Bowling Alyssa , Pappert Eric , Wu Stacy ,   for the CTH-302 Study Investigators
Published: November 2023

Background: Apomorphine sublingual film (SL-APO) and subcutaneous apomorphine (SC-APO) have been used for the treatment of OFF episodes in Parkinson’s disease (PD). No study has prospectively compared efficacy and safety of these formulations. Objective: To compare SL-APO with SC-APO for treatment of OFF episodes in PD. Methods: An open-label, randomized, crossover study assessed SL-APO versus SC-APO in patients with PD and OFF episodes ( N = 113). Doses were optimized in randomly assigned order. SL-APO dose initiation (10 mg) occurred in clinic; further dose optimization (15–30 mg; 5-mg increments) occurred primarily at home. SC-APO dosing (2–6 mg; 1-mg increments) occurred entirely in clinic. After a 3–7-day washout, patients were randomized 1 : 1 to 4 weeks of treatment with their optimized dose of SL-APO or SC-APO, followed by washout and 4 weeks of crossover treatment. Results: Propensity score matching applied on 159 patients (STN-DBS n = 75, MED n = 84) resulted in 40 patients in each treatment group. At 36-month follow-up, STN-DBS led to significantly better PDSS and PDQ-8 change scores, which were significantly correlated. We observed no significant effects for HADS and no significant correlations between change scores in PDSS, HADS, and LEDD. Conclusions: We report Class IIb evidence of beneficial effects of STN-DBS on quality of sleep at 36-month follow-up, which were associated with QoL improvement independent of depression and dopaminergic medication. Our study highlights the importance of sleep for assessments of DBS outcomes. Results: No difference was observed between SL-APO and SC-APO for change from predose to 90 minutes postdose in Movement Disorder Society Unified Parkinson’s Disease Rating Scale Part III score at week 4 (primary endpoint), assessed by a blinded rater (–13.6 vs. –13.8, respectively; p = NS). Overall, 72.2% of patients preferred SL-APO compared with SC-APO/no preference ( p = 0.0002) per the Treatment Preference Questionnaire (secondary endpoint). Patients reported greater satisfaction with SL-APO compared with SC-APO, per mean scores of convenience (73.7 vs. 53.5) and global satisfaction (63.9 vs. 57.6) on the Treatment Satisfaction Questionnaire for Medication (other endpoint). The safety profiles of both treatments were generally comparable and were well-tolerated. Conclusions: Patients reported overall preference for and greater satisfaction with SL-APO over SC-APO.
Design of displacement ventilation system in museum premises
Authors: Vakhula V. 
Published: November 2023

In museum premises located in architectural monuments, an important issue is ensuring the regulatory parameters of the air environment. And the method of organizing air exchange in exhibition and exposition halls. In such buildings, it is impossible to conduct air ducts, therefore existing ducts from fireplaces and natural exhaust ducts are used. The article discussed the National Center of Folk Culture "Ivan Honchar Museum". In a series of field studies, the average air temperature in the room was within twz = 20 °С, and the relative humidity was φwz = 55-60 % in the exhibition halls. two options for organizing air exchange. A three-dimensional model was created for the study of air exchange and air flow between halls, and air movement was simulated in two variants for rooms No. 40, 47 and 48. Taking into account the field studies and mathematical modeling of air exchange organization options, a project for the modernization of ventilation and air conditioning systems was proposed.
ALR_Sim_tracks - trajectory simulator software to assist the search for favourable trajectories for the exploration of the triple Asteroid 2001-SN263 from the Laser Altimeter point of view
Authors: Vicente de Brum Antonio Gil 
Published: November 2023

_ALR_Sim_tracks_ is a trajectory simulator/analyser software for space missions involving the exploration of the surface of celestial bodies using optical instrumentation. The software was created to carry out an analysis that would allow the identification of favourable trajectories for carrying out the intended exploration of the triple asteroid 2001-SN263 during Brazil's first deep space mission (ASTER mission) [1][2] from the point of view of the Laser Altimeter, called ALR, which is one of the optical instruments designed to fly in this mission [3][4]. With its use, trajectories of interest for the intended exploration were simulated and evaluated to identify the most promising ones, which were then presented [5][6]. This article contains a presentation and description of this software, and everything involved in its operation. Because it was first created to represent the view of a laser altimeter, the descriptions involve this instrument. However, Other optical instruments of similar operation are also considered for analysis once a proper modelling is available.