bluuebunny/crossref_metadata_2025_split huggingface dataset:
Electrospinning of photochromic poly(ethylene terephthalate) nanofibers toward information authentication
Authors: El‐Newehy Mohamed H. , Aldalbahi Ali , Thamer Badr M. , Abdulhameed Meera Moydeen 
Published: November 2023

AbstractThe use of photochromism to enhance the anti‐counterfeiting of a wide range of economic goods is an intriguing prospect. Creating a translucent anti‐counterfeiting nanocomposite is critical to improving the engineering procedures of the encoding materials. Herein, we use electrospinning to produce anti‐counterfeiting nanofibrous films from nanoparticles of rare‐earth aluminate (NREA) and recycled poly(ethylene terephthalate) (PET). Different nanofiber films with distinct emission properties were created using different ratios of NREA. The ultraviolet (UV)‐induced photochromism of the NREA@PET nanofibers was proved. Immobilizing NREA at the nanoscale ensures better dispersion without agglomeration in the PET nanofibrous matrix, which is essential for the development of transparent NREA@PET films. Diameters of 4–13 nm for NREA were shown using transmission electron microscopy. X‐ray fluorescence spectroscopy, energy‐dispersive X‐ray spectroscopy, Fourier‐transform infrared spectroscopy, scanning electron microscopy, elemental mapping, and other techniques were used to investigate the photochromic nanofibers' morphology, elemental contents, optical transmittance, and mechanical performance. It was observed that the nanofiber diameter in NREA@PET was between 150 and 250 nm. Excitation and emission bands of electrospun NREA@PET nanofibrous films were monitored at 365 and 518 nm, respectively. The superhydrophobicity of NREA@PET increased with increasing NREA concentration. The transparent nanofibers exhibited fast and reversible dual‐mode fluorescent photochromism to green emission without fatigue when stimulated beneath a UV source. Using the present anti‐counterfeiting films can be regarded as a simple technique to develop flexible materials to launch an ideal marketplace with affordable societal and economic advantages.
The effect of transcutaneous auricular vagus nerve stimulation on cycling ergometry and recovery in healthy young individuals
Authors: Hatik Sefa Haktan , Arslan Mesut , Demirbilek Ömer , Özden Ali Veysel 
Published: November 2023

AbstractBackgroundIt is aimed to examine the potential benefits and effects of the use of transcutaneous auricular vagus nerve stimulation (VNS) for sporting purposes on recovery, fatigue, and sportive performance level.MethodsIn this study, 90 people between the ages of 18–23 were participated. They were randomly divided into three groups as bilateral sham, unilateral left, and bilateral VNS. A 4‐day protocol was applied to the participants. Cycling exercise was performed with maximum performance for 30 min under the same watt load. Pulse, systolic and diastolic blood pressure, distance, pain, fatigue, lactic acid level, and autonomic nervous system were evaluated.ResultsWithin the groups, there was a statistically significant difference between the data (p < .05) except for the distance covered parameter. When we compare the groups, in addition to the distance traveled in all groups, there is no statistically significant difference in the 1st day 1st measurement and 2nd measurement data of all parameters (p > .05 When we compared the data according to days, there was a statistically significant difference between bilateral stimulation (BS) and unilateral stimulation, only pain and fatigue levels (p < .05).ConclusionIn our study, we saw that BS application gave positive results in reducing pain and fatigue due to cycling exercise compared to other applications. Similar results were obtained when we evaluated the data on a daily basis. We believe that VNS will be beneficial in reducing pain and fatigue, especially during and after the competition halftime.
Uroprotective Potential of Campesterol in Cyclophosphamide Induced Interstitial Cystitis; Molecular Docking Studies
Authors: Javed Joham , Anjum Irfan , Najm Saima , Ali Naila , Nasir Hayat Malik Muhammad , Jahan Shah , Dawoud Turki M. , Nafidi Hiba‐Allah , Bourhia Mohammed 
Published: November 2023

AbstractCyclophosphamide (CYP) is commonly used to treat cancer of the ovaries, breast, lymph, and blood system and produces interstitial cystitis (IC) via its urotoxic metabolite: i. e., acrolein. The present study was aimed to investigate the uroprotective effect of campesterol (a steroidal phytochemical) in cyclophosphamide induced IC. IC was induced by CYP (150 mg/kg, i. p.) in rats. The Enzyme linked immunosorbent assays for oxidative stress markers and Polymerase Chain Reaction (PCR) for inflammatory cytokines were carried out. The Tissue Organ Bath Technique was used for the evaluation of the spasmolytic effect of campesterol. Different pharmacological antagonists have been used to explore the mechanism of action of campesterol. Treatment with campesterol (70 mg/kg) reduced nociception (55 %), edema (67 %), hemorrhage (67 %), and protein leakage significantly (94 %). The antioxidant activity of campesterol was exhibited by a fall in MDA, NO, and an elevation in SOD, CAT, and GPX levels. Campesterol presented anti‐inflammatory potential by decreasing IL‐1, TNF‐α, and TGF‐β expression levels. Histologically, it preserved urothelium from the deleterious effect of CYP. Campesterol showed a spasmolytic effect by reducing bladder overactivity that was dependent on muscarinic receptors, voltage‐gated calcium and KATP channels, and cyclo‐oxygenase pathways. In silico studies confirmed the biochemical findings. The findings suggest that campesterol could be valorized as a possible therapeutic agent against cyclophosphamide‐induced interstitial cystitis.
Effects of atherectomy on major adverse limb events for femoropopliteal interventions: Vascular Quality Initiative registry
Authors: Effoe Valery S. , Mewissen Mark W. , Bajwa Tanvir K. , Khitha Jayant , Kostopoulos Louie , Ammar Khawaja A. , Nfor Tonga K. 
Published: November 2023

AbstractBackgroundAtherectomy use in treatment of femoropopliteal disease has significantly increased despite scant evidence of benefit to long‐term clinical outcomes.AimsWe investigated the clinical benefits of atherectomy over standard treatment for femoropopliteal interventions.MethodsUsing data from the Society of Vascular Surgery's Vascular Quality Initiative (VQI) registry, we identified patients who underwent isolated femoropopliteal interventions for occlusive disease. We compared 13,423 patients treated with atherectomy with 47,371 receiving standard treatment; both groups were allowed definitive treatment with a drug‐coated balloon or stenting. The primary endpoint was major adverse limb events (MALEs), which is a composite of target vessel re‐occlusion, ipsilateral major amputation, and target vessel revascularization.ResultsMean age was 69 ± 11 years, and patients were followed for a median of 30 months. Overall rates of complications were slightly higher in the atherectomy group than the standard treatment group (6.2% vs. 5.9%, p < 0.0001). In multivariable analysis, after adjusting for demographic and clinical covariates, atherectomy use was associated with a 13% reduction in risk of MALEs (adjusted odds ratio [aOR]: 0.87; 95% confidence interval [CI]: 0.77–0.98). Rates of major and minor amputations were significantly lower in the atherectomy group (3.2% vs. 4.6% and 3.3% vs. 4.3%, respectively, both p < 0.001), primarily driven by a significantly decreased risk of major amputations (aOR 0.69; 95% CI: 0.52–0.91). There were no differences in 30‐day mortality, primary patency, and target vessel revascularization between the atherectomy and standard treatment groups.ConclusionsIn adults undergoing femoropopliteal interventions, the use of atherectomy was associated with a reduction in MALEs compared with standard treatment.
International survey of chronic total occlusion percutaneous coronary intervention operators
Authors: Simsek Bahadir , Rempakos Athanasios , Kostantinis Spyridon , Alexandrou Michaella , Karacsonyi Judit , Rangan Bavana V. , Mastrodemos Olga C. , Mutlu Deniz , Abi Rafeh Nidal , Alaswad Khaldoon , Avran Alexandre , Azzalini Lorenzo , ElGuindy Ahmed , Egred Mohaned , Goktekin Omer , Gorgulu Sevket , Jaber Wissam , Kearney Kathleen E. , Kirtane Ajay J. , Lombardi William L. , Mashayekhi Kambis , McEntegart Margaret , Nicholson William , Rinfret Stephane , Allana Salman S. , Sandoval Yader , Nicholas Burke M. , Brilakis Emmanouil S. 
Published: November 2023

AbstractBackgroundContemporary chronic total occlusion (CTO) percutaneous coronary intervention (PCI) practice has received limited study.AimTo examine the contemporary CTO PCI practice.MethodsWe performed an online, anonymous, international survey of CTO PCI operators.ResultsFive hundred forty‐five CTO PCI operators and 190 interventional cardiology fellows with an interest in CTO PCI participated in this survey. Almost half were from the United States (41%), most (93%) were men, and the median h/week spent in the hospital was 58. Median annual case numbers were 205 (150−328) for PCIs and 20 (5−50) for CTO PCIs. Almost one‐fifth (17%) entered CTO cases into registries, such as PROGRESS‐CTO (55%) and EuroCTO (20%). More than one‐third worked at academic institutions (39%), 31% trained dedicated CTO fellows, and 22% proctored CTO PCI. One‐third (34%) had dedicated CTO PCI days. Most (51%) never discharged CTO patients the same day, while 17% discharged CTO patients the same day >50% of the time. After successful guidewire crossing, 38% used intravascular imaging >90% of the time. Most used CTO scores including J‐CTO (81%), PROGRESS‐CTO (35%), and PROGRESS‐CTO complications scores (30%). Coronary artery perforation was encountered within the last month by 19%. On a scale of 0−10, the median comfort levels in treating coronary artery perforation were: covered stents 8.8 (7.0−10), coil embolization 5.0 (2.1−8.5), and fat embolization 3.7 (0.6−7.3). Most (51%) participants had a complication cart/kit and 25% conducted regular complication drills with catheterization laboratory staff.ConclusionContemporary CTO PCI practices vary widely. Further research on barriers to following the guiding principles of CTO PCI may improve patient outcomes.
Preparation of Heterojunction Catalysts for Photocatalysis byin‐situSynthesis: What We Should Do Next?
Authors: Wu Jiaming , Du Jun , He Xiaoyu , Guo Xinwen 
Published: November 2023

AbstractThe construction of heterojunction is one of the most effective ways to improve the activity of photocatalysts, whilein‐situsynthesis technology can provide the most intimate interfacial contact during the preparation of heterojunction. Heterojunction photocatalysts prepared byin‐situsynthesis have shown excellent performance in solar energy conversion and environmental purification. The convenient preparation process is also suitable for large‐scale production. In this review, we summarize the common synthesis methods and characterization techniques for thein‐situsynthesis of heterojunctions, and list the applications of these catalysts in the photocatalytic field. Finally, we discuss the limitations of the current research onin‐situsynthesis and look forward to its great prospects.
Recent Advances in Asymmetric Synthesis of Chiral Cyclobutenes
Authors: Hu Fangdong , Zhao Yueting , Che Lin , Yan Xufei , Xia Ying 
Published: November 2023

AbstractCyclobutene scaffolds occur in natural products and bioactive compounds. Their unique structural features and intrinsic ring strain make cyclobutene a type of important building block in synthetic chemistry. In recent years, considerable efforts have been dedicated to the synthesis of chiral cyclobutenes. Enantioselective [2+2] cycloadditions and functionalization of cyclobutene derivatives have emerged as powerful and reliable protocols for achieving this goal, resulting in significant progress in this field. This review provides a comprehensive summary of the recent advancements in the asymmetric synthesis of chiral cyclobutenes, and the discussion is logically divided into four parts according to the reaction mode.
Experimental and Computational Studies for the Synthesis of Functionalized Cyclopropanes from 2‐Substituted Allylic Derivatives with Ethyl Diazoacetate
Authors: Zhao Chengtao , Besset Tatiana , Legault Claude Y. , Jubault Philippe 
Published: November 2023

AbstractThe catalytic asymmetric synthesis of highly functionalized cyclopropanes from 2‐substituted allylic derivatives is reported. Using ethyl diazo acetate, the reaction, catalyzed by a chiral ruthenium complex (Ru(II)‐Pheox), furnished the corresponding easily separable cis and trans cyclopropanes in moderate to high yields (32‐97 %) and excellent ee (86‐99 %). This approach significantly extends the portfolio of accessible enantioenriched cyclopropanes from an underexplored class of olefins. DFT calculations suggest that an outer‐sphere mechanism is operative in this system.
Pyranthiones/Pyrones: “Click and Release” Donors for Subcellular Hydrogen Sulfide Delivery and Labeling**
Authors: Huang Wei , Gunawardhana Nipuni , Zhang Yunlei , Escorihuela Jorge , Laughlin Scott T. 
Published: November 2023

AbstractHydrogen sulfide (H2S), one of the most important gasotransmitters, plays a critical role in endogenous signaling pathways of many diseases. However, developing H2S donors with both tunable release kinetics and high release efficiency for subcellular delivery has been challenging. Here, we describe a click and release reaction between pyrone/pyranthiones and bicyclononyne (BCN). This reaction features a release of CO2/COS with second‐order rate constants comparable to Strain‐Promoted Azide‐Alkyne Cycloaddition reactions (SPAACs). Interestingly, pyranthiones showed enhanced reaction rates compared to their pyrone counterparts. We investigated pyrone biorthogonality and demonstrated their utility in protein labeling applications. Moreover, we synthesized substituted pyranthiones with H2S release kinetics that can address the range of physiologically relevant H2S dynamics in cells and achieved quantitative H2S release efficiency in vitro. Finally, we explored the potential of pyranthiones as H2S/COS donors for mitochondrial‐targeted H2S delivery in living cells.
Facile Access to Cationic Methylstannylenes and Silylenes Stabilized by E−Pt Bonding and their Methyl Group Transfer Reactivity**
Authors: Govindarajan Ramadoss , Fayzullin Robert R. , Deolka Shubham , Khaskin Eugene , Vasylevskyi Serhii , Vardhanapu Pavan K. , Pal Shrinwantu , Khusnutdinova Julia R. 
Published: November 2023

AbstractWe describe a family of cationic methylstannylene and chloro‐ and azidosilylene organoplatinum(II) complexes supported by a neutral, binucleating ligand. Methylstannylenes MeSn:+ are stabilized by coordination to PtII and are formed by facile Me group transfer from dimethyl or monomethyl PtII complexes, in the latter case triggered by concomitant B−H, Si−H, and H2 bond activation that involves hydride transfer from Sn to Pt. A cationic chlorosilylene complex was obtained by formal HCl elimination and Cl− removal from HSiCl3 under ambient conditions. The computational studies show that stabilization of cationic methylstannylenes and cationic silylenes is achieved through weak coordination to a neutral N‐donor ligand binding pocket. The analysis of the electronic potentials, as well as the Laplacian of electron density, also reveals the differences in the character of Pt−Si vs. Pt−Sn bonding. We demonstrate the importance of a ligand‐supported binuclear Pt/tetrel core and weak coordination to facilitate access to tetrylium‐ylidene Pt complexes, and a transmetalation approach to the synthesis of MeSnII:+ derivatives.
Efficient Photolytic Halogenation and Oxidation of Unactivated Alkyl sp3 C—H Bonds with Iodine(III)
Authors: Jia Hao , Li Nan , Tang Chunmei , Wang Yajuan , Xi Yonghao , Liao Rongbao , Xu Wei , Wu Fufang , Shen Xiaobao , Zhai Hongbin 
Published: November 2023

Comprehensive SummaryA metal‐free, green, and sustainable functionalization of unactivated alkyl sp3 C—H bonds is reported using iodine(III) as a feasible dehydrogenation agent under visible light or KBr, and alkyl chlorides, bromides, alcohols, and ketones could be constructed by addition of different coupling reagents. Cheap and safe iodobenzene diacetate was used to form a radical to activate the alkyl sp3 C—H bond in a highly efficient manner, which can construct different alkylation products by adding corresponding coupling reagents.
Genoarchitectonics of the larval zebrafish diencephalon
Authors: Wullimann Mario F. , Mokayes Nouwar , Shainer Inbal , Kuehn Enrico , Baier Herwig 
Published: November 2023

AbstractThe brain is spatially organized into subdivisions, nuclei and areas, which often correspond to functional and developmental units. A segmentation of brain regions in the form of a consensus atlas facilitates mechanistic studies and is a prerequisite for sharing information among neuroanatomists. Gene expression patterns objectively delineate boundaries between brain regions and provide information about their developmental and evolutionary histories. To generate a detailed molecular map of the larval zebrafish diencephalon, we took advantage of the Max Planck Zebrafish Brain (mapzebrain) atlas, which aligns hundreds of transcript and transgene expression patterns in a shared coordinate system. Inspection and co‐visualization of close to 50 marker genes have allowed us to resolve the tripartite prosomeric scaffold of the diencephalon at unprecedented resolution. This approach clarified the genoarchitectonic partitioning of the alar diencephalon into pretectum (alar part of prosomere P1), thalamus (alar part of prosomere P2, with habenula and pineal complex), and prethalamus (alar part of prosomere P3). We further identified the region of the nucleus of the medial longitudinal fasciculus, as well as the posterior and anterior parts of the posterior tuberculum, as molecularly distinct basal parts of prosomeres 1, 2, and 3, respectively. Some of the markers examined allowed us to locate glutamatergic, GABAergic, dopaminergic, serotoninergic, and various neuropeptidergic domains in the larval zebrafish diencephalon. Our molecular neuroanatomical approach has thus (1) yielded an objective and internally consistent interpretation of the prosomere boundaries within the zebrafish forebrain; has (2) produced a list of markers, which in sparse combinations label the subdivisions of the diencephalon; and is (3) setting the stage for further functional and developmental studies in this vertebrate brain.
Construction of supramolecular dimer based on benzothiazole derivative through host–guest interaction for photocatalysis
Authors: Li Xin‐Long , Wang Yue‐Bo , Wang Ying , Zhang Rong‐Zhen , Dong Rui‐Zhi , Liu Hui , Yu Shengsheng , Han Ning , Xing Ling‐Bao 
Published: November 2023

AbstractIn recent years, the development of photocatalysts based on noncovalent strategies has shown an important role in medical and organic materials. Herein, an organic fluorescent dye benzothiazole derivative (2‐(N,N‐diethylanilin‐4‐yl)‐4,6‐bis(3‐methylpyrazol‐1‐yl)‐1,3,5‐triazine [MPBT]) was designed and synthesized. It was encapsulated in the cavity of cucurbit[8]uril (CB[8]) to form a supramolecular dimer through host–guest interaction, which converted the dye into a highly efficient photocatalyst. With the formation of 2MPBT‐CB[8] supramolecular dimer, the emergence of host‐enhanced charge transfer interactions could significantly facilitate singlet to triplet through intersystem crossing. At the same time, the alternating structure of 2MPBT‐CB[8] facilitated the triplet states for further energy transfer and electron transfer. In addition, the electron transfer process with electron donor generated cationic free radical and photocatalyst negative ion free radical (), which in turn reacted with oxygen (O2) to form superoxide anion radical (). The generated could be used to catalyze the oxidative hydroxylation of aryl boronic acid. Therefore, the 2MPBT‐CB[8] had become a highly efficient photocatalyst for the oxidative hydroxylation of aryl boronic acid. This strategy of supramolecular dimerization provides a new strategy for the development of new photocatalysts based on noncovalent interactions.
Toward a new linpack‐like benchmark for heterogeneous computing resources
Authors: Carracciuolo Luisa , Mele Valeria , Sabella Gianluca 
Published: November 2023

SummaryThis work describes some first efforts to design a new Linpack‐like benchmark useful to evaluate the performance of Heterogeneous Computing Resources. The benchmark is based on the Schur Complement reformulation of the solution of a linear equation system. Details about its implementation and evaluation, mainly in terms of performance scalability, are presented for a computing environment based on multi NVIDIA GP‐GPUs nodes connected by an Infiniband network.
Bit duplication technique to generate hard quadratic unconstrained binary optimization problems with adjustable sizes
Authors: Li Xiaotian , Nakano Koji , Ito Yasuaki , Takafuji Daisuke , Yazane Takashi , Yano Junko , Kato Takumi , Ozaki Shiro , Mori Rie , Katsuki Ryota 
Published: November 2023

SummaryQuadratic unconstrained binary optimization (QUBO) is a combinatorial optimization to find an optimal binary solution vector that minimizes the energy value defined by a quadratic formula of binary variables in the vector. The main contribution of this article is to propose the bit duplication technique that can specify the number of duplicated bits, so that it can generate hard QUBO problem with adjustable sizes. The idea is to duplicate specified number of bits and then to give constraints so that the corresponding two bits take the same binary values. By this technique, any QUBO problem with bits is converted to a hard QUBO problem with bits . We use random QUBO problems, N‐Queen problems, traveling salesman problem and maximum weight matching problems for experiments. The performance of QUBO solvers including Gurobi optimizer, Fixstars Amplify AE, OpenJij with SA, D‐Wave samplers with SA, D‐Wave hybrid and ABS2 QUBO solver are evaluated for solving these QUBO problems. The experimental results show that only a small scale of duplicated bits can make QUBO problems harder. Hence, the bit duplication technique is a potent method to generate hard QUBO problems and generated QUBO problems can be used as benchmark problems for evaluating the search performance of QUBO solvers.
Design of Superior Electrocatalysts for Proton‐Exchange Membrane‐Water Electrolyzers: Importance of Catalyst Stability and Evolution
Authors: Guo Xiaoxuan , Wang Yongsheng , Zhu Wei , Zhuang Zhongbin 
Published: November 2023

AbstractBy virtue of the high energy conversion efficiency and compact facility, proton exchange membrane water electrolysis (PEMWE) is a promising green hydrogen production technology ready for commercial applications. However, catalyst stability is a challenging but often‐ignored topic for the electrocatalyst design, which retards the device applications of many newly‐developed electrocatalysts. By defining catalyst stability as the function of activity versus time, we ascribe the stability issue to the evolution of catalysts or catalyst layers during the water electrolysis. We trace the instability sources of electrocatalysts as the function versus time for hydrogen evolution reaction (HER) and oxygen evolution reaction (OER) in acid and classify them into internal and external sources. Accordingly, we summarize the latest studies for stability improvements into five strategies, i. e., thermodynamic stable active site construction, precatalyst design, support regulation, superwetting electrode fabrication, and catalyst‐ionomer interface engineering. With the help of ex‐situ/ in‐situ characterizations and theoretical calculations, an in‐depth understanding of the instability sources benefits the rational development of highly active and stable HER/OER electrocatalysts for PEMWE applications.