bluuebunny/crossref_metadata_2025_split huggingface dataset:
Gallium-68-labeled fibroblast activation protein inhibitor-46 PET in patients with resectable or borderline resectable pancreatic ductal adenocarcinoma: A phase 2, multicenter, single arm, open label non-randomized study protocol
Authors: Karbhari Aashna , Mosessian Sherly , Trivedi Kamaxi H. , Valla Frank , Jacobson Mark , Truty Mark J. , Patnam Nandakumar G. , Simeone Diane M. , Zan Elcin , Brennan Tracy , Chen Hongli , Kuo Phillip H. , Herrmann Ken , Goenka Ajit H. 
Published: November 2023

Background
Pancreatic ductal adenocarcinoma (PDAC) is a lethal disease prone to widespread metastatic dissemination and characterized by a desmoplastic stroma that contributes to poor outcomes. Fibroblast activation protein (FAP)-expressing Cancer-Associated Fibroblasts (CAFs) are crucial components of the tumor stroma, influencing carcinogenesis, fibrosis, tumor growth, metastases, and treatment resistance. Non-invasive tools to profile CAF identity and function are essential for overcoming CAF-mediated therapy resistance, developing innovative targeted therapies, and improved patient outcomes. We present the design of a multicenter phase 2 study (clinicaltrials.gov identifier NCT05262855) of [68Ga]FAPI-46 PET to image FAP-expressing CAFs in resectable or borderline resectable PDAC.

Methods
We will enroll up to 60 adult treatment-naïve patients with confirmed PDAC. These patients will be eligible for curative surgical resection, either without prior treatment (Cohort 1) or after neoadjuvant therapy (NAT) (Cohort 2). A baseline PET scan will be conducted from the vertex to mid-thighs approximately 15 minutes after administering 5 mCi (±2) of [68Ga]FAPI-46 intravenously. Cohort 2 patients will undergo an additional PET after completing NAT but before surgery. Histopathology and FAP immunohistochemistry (IHC) of initial diagnostic biopsy and resected tumor samples will serve as the truth standards. Primary objective is to assess the sensitivity, specificity, and accuracy of [68Ga]FAPI-46 PET for detecting FAP-expressing CAFs. Secondary objectives will assess predictive values and safety profile validation. Exploratory objectives are comparison of diagnostic performance of [68Ga]FAPI-46 PET to standard-of-care imaging, and comparison of pre- versus post-NAT [68Ga]FAPI-46 PET in Cohort 2.

Conclusion
To facilitate the clinical translation of [68Ga]FAPI-46 in PDAC, the current study seeks to implement a coherent strategy to mitigate risks and increase the probability of meeting FDA requirements and stakeholder expectations. The findings from this study could potentially serve as a foundation for a New Drug Application to the FDA.

Trial registration
@ClinicalTrials.gov identifier NCT05262855.
Prevalence and the association between clinical factors and Diabetes-Related Distress (DRD) with poor glycemic control in patients with type 2 diabetes: A Northern Thai cross-sectional study
Authors: Ruangchaisiwawet Achiraya , Bankhum Narumit , Tanasombatkul Krittai , Phinyo Phichayut , Yingchankul Nalinee 
Published: November 2023

BackgroundGlycemic control is important to prevent diabetic complications. However, evidence linking factors such as diabetes-related distress (DRD) to poor glycemic outcomes is lacking in Thailand. Therefore, this study aimed to investigate the prevalence and associated factors of poor glycemic control type 2 diabetes.MethodsA cross-sectional study was conducted on 127 type 2 diabetic patients between December 2021 and March 2022 at Maharaj Nakorn Chiang Mai Hospital, Thailand. Data collection included demographic data, clinical data (duration of being type 2 diabetes, diabetic treatment modalities, weight, height, blood pressure, FBS, and HbA1c), behavioral data (self-care behavior, physical activity, dietary assessment, smoking, alcohol consumption, and sleep quality), and psycho-social data (depression and DRD). Poor glycemic control was defined as not achieving the target HbA1c based on the 2021 American Diabetes Association (ADA) Guideline. Multivariable logistic regression was used to explore the associations between potential factors including DRD, and poor glycemic control.ResultsThe prevalence of poor glycemic control in patients with type 2 diabetes was 29.1%. Our analysis revealed that age under 65 years old (OR 6.40, 95% CI 2.07–19.77, p = 0.001), obesity (BMI ≥ 25 kg/m2) (OR 2.96, 95% CI 1.05–8.39, p = 0.041), and DRD (OR 14.20, 95% CI 3.76–53.64, p<0.001) were significantly associated with poor glycemic control. Three dimensions of DRD were associated with poor glycemic control, including emotional distress (OR 4.23, 95% CI 1.51–11.85, p = 0.006), regimen-related distress (OR 6.00, 95% CI 1.88–19.18, p = 0.003), and interpersonal distress (OR 5.25, 95% CI 1.39–20.02, p = 0.015).Conclusion and recommendationAge, obesity, and DRD are associated with poor glycemic control. A holistic approach that includes addressing DRD is crucial for improving glycemic outcomes in patients with type 2 diabetes. Further studies in broader populations using a cohort design are recommended.
STAT5B germline heterozygous variant presenting with lymphadenopathy, atopy, and short stature
Authors: Fuentes Laura Abrego , Roifman Maian 
Published: November 2023

Background: Signal Transducers and Activators of Transcription (STAT) proteins are fundamental for multiple cellular processes, including immunity. STAT5B serves as a signal transducer downstream of cytokine and growth factor-mediated activation. Aberrations in STAT5B are associated with the development of atopy, immunodeficiencies, autoimmunity, cancers, hematological disease, growth disorders, and lung disease. Biallelic STAT5B variants are associated with loss-of-function of the gene, and cause a recessive disorder characterized by growth hormone insensitivity and immune dysregulation. Clinically significant heterozygous variants result in either dominant negative or gain-of-function effects; these latter variants are rare and their impact on the immune system is less clearly delineated than those responsible for the recessive form of the condition. Aim: We describe the presentation, immune workup, and genetic findings in a pediatric patient with a novel STAT5B heterozygous variant. Methods: A thorough retrospective review of the patient’s chart was performed. Results: A four-year-old male presented with history of lymphadenopathy, eczema, asthma, food allergy, short stature, and recurrent upper and lower respiratory tract infections. Clinical trio whole exome sequencing identified a novel heterozygous variant (c.1A>G; p. Met1?) in STAT5B. His mother harbours the same heterozygous variant and has a history remarkable for atopy. Immune investigations on the child revealed persistent elevated IgE. The patient’s variant targets the STAT5B N-terminal domain, and represents the first case with a heterozygous variant affecting this region. Conclusion: We present a novel STAT5B variant associated with a dominantly-inherited growth and immune phenotype. This is the first report of a heterozygous variant affecting the N-terminal domain in association with a clinical phenotype, expanding the genotypic landscape of this disorder. Further investigations and follow up responses to growth hormone replacement are needed to better delineate the functional effect of the variant identified in this family. Statement of Novelty: We report a novel germline heterozygous STAT5B variant in a paediatric patient with lymphadenopathy, atopy, and short stature.
Moving Past Reliance – The Problem of a Reliance Requirement in Secondary Market Securities Litigation and Solutions from Select Jurisdictions
Authors: Yli-Kankahila Heidi M. K. 
Published: November 2023

Abstract

447Investors’ individual reliance on misstated inside information as an element of causation in securities litigation has provoked criticism. Scholarship has long acknowledged that a reliance requirement is not justified as damage may occur without an investor’s reliance on misstated inside information in the secondary market. This article analyses the reliance requirement in select European jurisdictions (the Netherlands, Germany, Sweden, Norway, Denmark, Finland, and the United Kingdom) and the United States. The article investigates whether a reliance requirement exists in the secondary market litigation regime in said jurisdictions and analyses whether a presumption of reliance exists to fulfil the reliance requirement. The article argues that most of the suggested solutions to resolve the reliance problem are not entirely satisfactory. An often-suggested presumption of reliance, while leavening the investors’ burden of proof, keeps the reliance requirement in place. This article submits that proof of individual investors’ reliance should not be required in secondary market inside information misstatement cases. Discarding the reliance requirement altogether makes any presumptions redundant as well.448
Remontar las cumbres: la incorporación de Dante, Petrarca y Boccaccio a la historia literaria castellana
Authors: Valero Moreno Juan Miguel 
Published: November 2023

Resumen
La integración de las tres coronas en las literaturas ibéricas se verifica, en sustancia, por vías alternativas y complementarias, a partir del último cuarto del siglo XIV, en los reinos de Castilla y Aragón. La difusión conocida de determinados textos de Dante, Petrarca y Boccaccio toma impulso, a partir de nuevas adaptaciones y traducciones, con el ascenso de la dinastía Trastámara. Su incorporación no será pasiva, sino que cobra sentido en un proceso de aculturación, infiltración y acomodación en las tradiciones literarias ibéricas, que se encuentran en transformación. La apropiación de estos autores da lugar a complejos artefactos textuales que derivan en audaces dispositivos culturales y políticos. Tal operación, cuya cronología se nos aparece hoy fracturada, ha de verificarse tanto en la presencia de los textos en las bibliotecas ibéricas como en la capacidad de generar un conjunto de formas y contenidos que propiciarán una translación del canon itálico al ibérico.
A panoramic view of acceptability judgments in Polish generative linguistics
Authors: Łęska-Bayraktar Paulina , Żychliński Sylwiusz 
Published: November 2023

Abstract
This article aims to provide a concise overview of the most relevant topics concerning the implementation of acceptability judgments in generative research. The first part focuses on theoretical issues, including the reasons underlying the prevalence of acceptability judgments, the skepticism towards the wide use of informal judgments, the arguments for and against the continued use of informal data points and the challenges related to experimental data collection and the gradient nature of judgments. The second part further explores the concept of gradient acceptability and its different sources. We suggest that violations of soft constraints correspond with partial acceptability, unlike violations of hard constraints, which cause strong unacceptability. Based on our investigation of selected partially acceptable syntactic phenomena in Polish, we show that their syntactic accounts can also benefit from the inclusion of non-syntactic factors, which can be more reliably identified via experimental methodology. More specifically, we propose that (i) the lack of subject orientation of pronominal possessives could be attributed to lexical ambiguity, (ii) coreference of possessive cataphora is facilitated by antecedent backgrounding and (iii) WCO is improved by focus marking of the possessive pronoun, (iv) while processing of the last two structures could be ameliorated with more informative fillers.
Análise crítica da implementação do Lean Office: um estudo de casos múltiplos
Authors: Cardoso Grasiele Oliveira Alves , Alves João Murta 
Published: November 2023

O presente artigo tem como objetivo realizar uma análise crítica, por meio do estudo de casos múltiplos, dos oito passos para implementação do Lean Office que são propostos por Tapping e Shuker, no livro “Lean Office: gerenciamento do fluxo de valor para áreas adminitrativas – 8 passos para planejar, mapear e sustentar melhorias Lean nas áreas administrativas”, com o intuito de verificar sua eficácia. Para tanto, foi realizada uma análise crítica de três artigos publicados que referenciam a utilização dos passos proposto por Tapping e Shuker (2010), em comparação com os passos descritos no livro. Os resultados verificados indicam que os passos propostos auxiliam as organizações na implementação do Lean Office, tendo em vista que o problema inicial de cada caso foi resolvido, o que pode ser constatado devido as melhorias obtidas. Sendo assim, é possível concluir que os passos propostos são eficazes, pois sua implementação permitiu que, em cada caso, os resultados esperados fossem alcançados. Palavras-chave: Lean Office. Eficácia. Melhorias.
Aproximações entre Gestão do Conhecimento e Processos de Negócios: uma revisão de literatura a partir do mapeamento dos artigos mais citados na ISI Web of Science
Authors: Hurtado Segundo Raimundo Benitez , Carpes Carlos Eduardo Pereira , Inomata Danielly Oliveira , Varvakis Gregório 
Published: November 2023

Apresenta revisão de literatura sobre a aplicação da Gestão do Conhecimento e Processos de Negócios, permitindo visualizar as temáticas abordadas. Busca fornecer aos pesquisadores de Gestão do Conhecimento um mapa sistemático e objetivo das ideias e diferentes conceitos no desenvolvimento do campo da Gestão do Conhecimento, especificamente aqueles relacionados a Processos de Negócio. O método utilizado é uma revisão de literatura a partir do levantamento de referências na base de dados Web of Science do ISI – Information Sciences Institute, da qual, mediante recortes quantitativos, chegou-se a um número de 15 (quinze) artigos minuciosamente analisados. Com isso, este estudo identificou a articulação entre publicações na medida em que confirmou suas posições e contribuições para o desenvolvimento da Gestão do Conhecimento em organizações. E por fim, aglutinou-se o conteúdo levantado e organizou-se de forma sistêmica compondo o mapa sistemático. Na analise dos resultados tece as vertentes levantadas com a pesquisa e conclui que as discussões parecem caminhar para mudanças de processos e sistemas de informação adequados ao cliente como influentes no contexto organizacional. Palavras-chave: Gestão do Conhecimento; Processos de Negócios; Revisão de Literatura.
Análisis de susceptibilidad a deslizamientos empleando el proceso de jerarquía analítica en una carretera Amazónica del Ecuador
Authors: Cargua Cristian J. , Espin Ronny , Valencia Bryan G. , Simbaña Marco , Araujo Sebastián , Ocampos Anderson , Cornejo Carolina 
Published: November 2023

The Puyo-Tena roadway is prone to landslides due to the geodynamics, geomorphology, and geological materials of the area (unstable outcrops and strata). In recent years, this problem has persistently caused the road to be partially or completely disabled on numerous occasions. The objective of the research was to generate a cartographic model of landslides susceptibility based on variables such as slope, geological formations, land cover and land use, as well as distances to faults, road, and rivers. The degree of landslides incidence was estimated as the linear combination of the weighted variables using the analytic hierarchy process. The importance of this semi quantitative method lies in its ability to break down a complex decision problem into a simpler and more coherent decision model. The resulting cartographic model was classified into five susceptibility categories: very low, low, moderate, high, and very high. The results showed that 17 km out of the 80 km of the Puyo-Tena roadway have a high probability of landslides, which is equivalent to 21.25% of the road. Furthermore, within this percentage, it was determined that there are fifteen regions with a high probability of landslides due to their location in areas with steep slopes, porous and permeable lithology, a large number of rivers, and agricultural soils. The area under the curve (AUC) of the receiver operating characteristic (ROC) was used for model verification. The verification results showed that the cartographic model for the study area has an accuracy value of 83.7%. The cartographic model of landslide susceptibility will enable relevant decisions to be made to mitigate potential hazards that may endanger transporters, material goods, and residents of the area.
Process monitoring and automated data analysis in 3D printing
Authors: Michalkowski Carissa , Echsel Markus 
Published: November 2023

The Fused Layer Modeling (FLM) 3D printing process becomes more and more common in industrial applications. In an environment of rapid production and customer services, the printed parts need to be quality proved for a save and reliable usage. In order to achieve this without expensive post processing steps, the monitoring and analysis of the printing process is necessary. This work presents the results of feasibility studies for different low cost sensors to monitor the FLM printing process and the development of a data analysis system for evaluating the printing process. The process should be sufficiently monitored to avoid costly ensuing part testing.
PERSEPSI WANITA TANI TERHADAP PEMANFAATAN TANAH PEKARANGAN (PTP) DALAM MENUNJANG KETAHANAN PANGAN DI DESA CUCUM KECAMATAN KUTA BARO KABUPATEN ACEH BESAR
Authors: Darma Budi , Mujiburrahmad Mujiburrahmad , Susanti Elly 
Published: November 2023

Kelompok Wanita Tani (KWT) merupakan kelompok swadaya yang berasal dari, oleh dan untuk masyarakat dengan jumlah anggota tertentu. Penelitian ini bertujuan untuk mengetahui persepsi wanita tani terhadap Pemanfaatan Tanah Pekarangan (PTP) dalam menunjang ketahanan pangan. Teknik pengambilan sampel dilakukan secara sensus yaitu seluruh wanita tani kelompok kembang tani yang aktif memanfaatkan tanah pekarangan sebanyak 30 orang. Hasil penelitian menunjukkan bahwa wanita tani kelompok Kembang Tani memiliki karakteristik internal yaitu berumur 55 tahun (33%) dengan pendidikan formal SD (40%), memiliki jumlah anggota keluarga 1 – 4 orang (74%) dengan pendapatan Rp.500.000 – 1.000.000 (67%), memiliki luas lahan pekarangan 500 m2 (70%) dengan curahan waktu pemanfaatan 5 jam/hari (70%), dan kekosmopolitan termasuk dalam kategori rendah (97%) sedangkan motivasi termasuk dalam kategori tinggi (100%). Karakteristik eksternal seperti intensitas penyuluhan dan suasana kelompok termasuk dalam kategori tinggi (100%) sedangkan ketersediaan sarana dan produksi termasuk dalam kategori sedang (53%). Tingkat persepsi wanita tani kelompok Kembang Tani terhadap pemanfaatan lahan pekarangan dalam menunjang ketahanan pangan tergolong sangat baik dengan pencapaian skor 4.2. Women Farmers Group (KWT) is a self-help group originating from, by and for the community with a certain number of members. This study aims to determine the perceptions of women farmers on Utilization of Yard Land (PTP) in supporting food security. The sampling technique was carried out by means of a census, i.e. all female farmers in the farmer's group who actively used their yard land were 30 people. The results showed that female farmers in the Kembang Tani group had internal characteristics, namely aged 55 years (33%) with formal elementary school education (40%), had a family of 1 – 4 people (74%) with an income of IDR 500,000 – 1,000. 000 (67%), have a yard area of 500 m2 (70%) with an outpouring of utilization time 5 hours/day (70%), and cosmopolitanness is included in the low category (97%) while motivation is included in the high category (100% ). External characteristics such as the intensity of counseling and group atmosphere are included in the high category (100%) while the availability of facilities and production is included in the medium category (53%). The level of perception of female farmers in the Kembang Tani group regarding the use of yard land in supporting food security is classified as very good with a score of 4.2. Keywords: Farmer Women's Group, Perception, Utilization of Yard Land, Food Security
Cytomegalovirus esophagitis associated with arytenoid cyst in an immunocompetent host
Authors: Anchan Shibani V. , Khialani Anjali , Raj Athira 
Published: November 2023

CMV esophagitis is usually encountered in immunocompromised individuals and esophagus is rarely affected in immunocompetent individuals. CMV esophagitis associated with arytenoid cyst has not yet been reported in literature to the best of my knowledge and can be considered in case of recurrence of cyst following excision. The objective of this study is to report the unique presentation of CMV in an immunocompetent patient. A middle-aged immunocompetent lady presenting with dysphagia was diagnosed to have arytenoid cyst. Biopsy from upper esophagus revealed cytomegalovirus inclusion bodies and immunological test were performed to confirm the pathology. The cyst excision lead to recurrence. It was excised again followed by a course of intravenous ganciclovir. Currently, the role of antiviral in treatment of CMV esophagitis in immunocompetent individual is not well established. We have obtained good result in this patient with a course of Ganciclovir following excision of the cyst. The rarity of cytomegaloviral upper esophageal involvement, its association with arytenoid cyst and the utility of antivirus in treatment of an immunocompetent host makes this case report unique and interesting.
Nifedipine versus magnesium sulfate in the management of preterm labour- A randomised controlled trial
Authors: Sunil K S  , Bhat Shalini , Jain Apoorva 
Published: November 2023

Preterm labour is the leading cause of perinatal morbidity and mortality worldwide. Preterm birth accounts for 75% of neonatal deaths and 50% of long-term morbidity including respiratory disease and neuro-developmental impairment. The use of tocolysis in women in preterm labour aims to inhibit uterine contractions and reduce perinatal morbidity and mortality associated with early delivery.To study the effect and compare the efficacy of Nifedipine and Magnesium sulphate in management of preterm labour.: This randomized controlled trial was performed on 80 women with preterm labor between 28 and 37 weeks of gestation who were randomly assigned to receive either MgSO4 or nifedipine. All patients were checked for successful prolongation of pregnancy who had not been delivered at 48 hours [primary tocolytics effects] and more than 7 days [secondary tocolytics effects] after beginning the treatment and side effects of tocolysis.: From 80 patients, 40 received nifedipine and 40 received MgSO4. There were no differences in suppression of labor pain in 24 hours, 48 hours and 7 days between the two groups. Even though there were no statistically significant differences in one-minute and five-minute Apgar scores, neonatal respiratory distress syndrome between the groups neonates of MgSO4 group had more NICU admission which is significant (p value 0.049).: Oral nifedipine is as effective as magnesium sulfate with regard to inhibition of preterm labor.