bluuebunny/crossref_metadata_2025_split huggingface dataset:
Addressing Health Disparities in Hematologic Malignancies: from Genes to Outreach
Authors: Flowers Christopher R. , Anantha Rachel W. , Leautaud Veronica , Desai Pinkal , Donald Chancellor E. , Hildebrandt Michelle A.T. , Koff Jean L. , Tamimi Rulla M. , Cozen Wendy , Nze Chijioke , Melnick Ari M. 
Published: February 2025

Abstract
Hematologic malignancies exhibit disparities in risk and outcomes across populations. A systematic review to identify prospective studies addressing disparities among patients with hematologic malignancies with an intervention or analysis at any level in the “Cells-to-Society” model identified few studies and demonstrated literature gaps, which experts have supplemented with relevant citations. This review presents current research on diagnosis, treatment, and survival disparities and explores the roles of biology, cancer centers, community outreach, patient advocacy, and policies. Emphasis is placed on multilevel collaborative approaches to promote equity in healthcare delivery and improve survival.

Significance:
This review underscores our shared responsibility to champion multidimensional strategies rooted in basic and translational science, community involvement, and societal responsiveness for a meaningful impact. Unifying themes include the need to enhance collaborative infrastructure to engage laboratory researchers, epidemiologists, data scientists, clinicians, patients, community leaders, and policymakers; patient-level support services; outreach, education, and navigation for patients at the community level; recruitment and retention of underrepresented groups in the healthcare and research workforce; and funding for these efforts.
Understanding Nocturnally-driven Extreme Precipitation Events over Lake Victoria in a Convection-Permitting Model
Authors: Glazer Russell H. , Coppola Erika , Giorgi Filippo 
Published: February 2025

Abstract
Each year on the order of 1000 fishers are lost on Lake Victoria (LV) due to hazardous weather and intense nighttime thunderstorms making LV one of the most hazardous lakes in the world. In this study we present a 10-year (2006-2015) convection-permitting (3km grid-spacing) simulation of the Lake Victoria Basin (LVB) using the non-hydrostatic version of the regional model RegCM (RegCM-NH). We construct composites of three different types of events over the lake during nighttime and early morning hours: 1) Dry events in which no rain fell over the lake, 2) Normal events in which rainfall over LV matches that of the annual mean, and 3) Extreme events in which rainfall exceeded the 99.99th percentile. In Extreme, an enhanced land breeze takes place along the western side of LV, resulting from convection along the high terrain to the west of the lake in the early evening and nighttime hours which cool the boundary layer through evaporative cooling, cold pools, and prolonged radiatively driven cooling. Cold pools are identified as playing a role in the triggering of convection over the lake, and/or the propagation of convection during Extreme events. Greater dynamical forcing in the lead up to an event exists in Extreme relative to Normal, while convective instability over LV is similar in Extreme and Normal. Dry events exhibit hazardous wind conditions over the lake occurring outside the main rainy season.
Effect of caffeine supplementation on physical performance in a 5 km cycling time trial of healthy young adult women in different phases of the menstrual cycle: A parallel, randomized, double-blind, placebo-controlled clinical trial
Authors: Mendes Gabriela Lima , Oliveira Higor Alexandre , Santana dos Reis Anderson , Nakamoto Fernanda Patti , Staibano Aline , Alvares Leonardo Azevedo , Simões Ferreira Raphael Einsfeld , Thomatieli-Santos Ronaldo Vagner , Quaresma Marcus V. L. dos Santos 
Published: February 2025

Background Although caffeine is the most studied ergogenic aid, few studies have been conducted to evaluate the effect of caffeine supplementation among women in different phases of the menstrual cycle (MC). Aim To verify the effect of caffeine supplementation and the MC phase on the performance of a 5 km cycling time trial of female exercise practitioners (FEP). Methods This was a parallel, double-blind, randomized, placebo-controlled clinical trial with a sample of women aged 18–35 years, all with regular MC. The caffeine (CAFG) and placebo (PLAG) groups performed the exercise test during the late follicular phase and mid-luteal phase. These time points were individually assessed according to each woman's MC. On the test day, they were instructed to intake a standardized meal. Subsequently, 30 min following the meal, volunteers consumed caffeine (6 mg·kg−1) or placebo. One hour following caffeine intake, the exercise protocol started. The participants were instructed to perform an all-out 5-km cycling time trial. Results Twenty-one women with a mean age of 26.6 years (PLAG, n = 10; 26.7 y; CAFG, n = 11; 26.5 y) were evaluated. The mean test duration was approximately 10-min, with no effect of the MC phase ( F = 0.410; p = 0.532), caffeine supplementation ( F = 2.23; p = 0.156), or interaction ( F = 0.298; p = 0.593). Likewise, we did not verify the effect of the MC phase ( F = 0.249; p = 0.625), caffeine supplementation ( F = 2.35; p = 0.146), or interaction ( F = 0.585; p = 0.456) on the mean power. Conclusion Neither caffeine supplementation nor the different MC phases had an impact on the 5-km cycling TT performance of FEP.
Impact of Product Market Competition on the Likelihood of Cross-Border Business Expansion
Authors: Islam Muhammad Rofiqul 
Published: February 2025

The effects of product market competition on a firm’s financial policy and business strategy are evident in extant literature. As a firm’s internationalization is a function of financial policy and business strategy, the firm’s decision is impacted by product market competition. However, prior studies lack empirical evidence supporting the relationship between product market competition and firm internationalization. We tested our hypotheses using a panel data set ( n = 64,147 firm-year observations) of publicly traded U.S. firms from 1990 to 2021 employing a panel data econometric model [i.e., partial least squared-ordinary least squares (OLS), fixed effect model]. The study results supported our hypothesis that product market competition reduces the likelihood of a firm’s internationalization. The study results enhance managerial understanding of internationalization decisions and suggest that businesses should consider the product market’s competitive position while making internationalization decisions. Policymakers should support those firms in overcoming the negative impact of product market threats to support internationalization.
Cyanidin 3-O-β-d-Glucoside from Black Bean Inhibits the Migration of Vascular Smooth Muscle Cells in the Presence of Adipocytes
Authors: Yuui Katsuya , Kudo Risa , Kasuda Shogo , Ueshima Shigeru 
Published: February 2025

Background The potential of cyanidin 3- O-β-D-glucoside (C3G), known for its anti-obesity and anti-diabetic properties, in suppressing arteriosclerosis progression remains unexplored. Purpose This study aimed to elucidate whether C3G prevents or ameliorates arteriosclerosis by investigating the effects of C3G on the transformation, proliferation, and migration of vascular smooth muscle cells (SMCs). Herein, we evaluated the effects of C3G on the migratory ability of SMCs in the presence of adipocytes. Materials and Methods SMCs and 3T3-L1 adipocytes were cocultured in a Boyden chamber, with SMCs positioned in the upper chamber and pre-adipocytes in the lower chamber. Pre-adipocytes were initially seeded in the lower chamber and prompted to undergo differentiation over days 0, 2, 4, 6, and 8. SMCs were seeded in the upper chamber. The quantification of cells that migrated through the membrane was carried out. The migratory potential of SMCs within the SMC/adipocyte coculture (SACC) setup was assessed by placing the upper chamber into wells containing adipocytes, with or without 0.1% C3G. Results The findings indicated that the accumulation of lipid droplets in adipocytes increased as the differentiation stage progressed. The amount of lipid droplets that accumulated upon the addition of C3G was significantly lower than that in the control. C3G was found to inhibit the active form of plasminogen activator inhibitor-1 (PAI-1) while enhancing the levels of the anti-inflammatory adipocytokine adiponectin. In the SACC, SMC migration increased alongside lipid droplet accumulation in adipocytes. We revealed that C3G decreased the active form of PAI-1 in the SACC and suppressed vascular SMC migration. Conclusion C3G inhibited the migration of SMCs in the SACC, highlighting its potential as a compound that can prevent arteriosclerosis and thrombus formation progression by suppressing hyperplasia of the vascular intima.
Level of Stress and Coping Strategies Adopted by Undergraduate Students Attending e-learning Classes: A Cross-sectional Study from Eastern India
Authors: Devi Rajita , Mohanan Keerthi , Thakur Pooja , Thakur Monika 
Published: February 2025

Background COVID-19 has forced universities across India and the world indeed, to suspend physical classrooms and shift to online classes to contain the outbreak, which caused stress among students and usage of adaptive and maladaptive coping mechanisms. Early identification of faulty coping mechanisms will help to reduce stress and prevent unwanted behavioural modification among students. Aim This study aimed to assess the levels of stress and coping strategies adopted by undergraduate students attending e-learning classes. Materials and Methods An online cross-sectional survey was conducted among undergraduate students of various disciplines (general degree, professional and others) from the Eastern part of India who were attending e-learning classes during the COVID-19 pandemic using a snowball sampling technique from July 2020 to June 2021. Level of stress associated with higher learning was assessed by Higher Education Stress Inventory scale (HESI) and coping strategies were assessed by the WHO Brief-COPE inventory. Results The mean age of the subjects was 21.63 ± 1.629 years. The mean score of the subjects for level of stress using HESI was 93.7 ± 11.35. The majority of the subjects had moderate stress (73%) related to e-learning followed by severe stress (27%). None of the participants had mild stress. Participants mostly used adaptive coping techniques to manage stress in both moderate and severe stress ( P < .001). Level of stress and year of study and monthly family income of the subjects were found to have a significant difference in mean scores ( P = .003). Year of the study and age had significant associations with adaptive coping techniques. Active coping (adaptive technique) was used by female students more than male students ( P = .02). Conclusion An increased awareness of e-learning and the specific stressors that students face, will allow educational institutions to offer specific and tailored support to their students.
Identification of Molecular Subtypes and Prognostic Features of Breast Cancer Based on TGF-β Signaling-related Genes
Authors: Qu Jia , Wang Mei-Huan , Gao Yue-Hua , Zhang Hua-Wei 
Published: February 2025

Objectives: The TGF-β signaling pathway is widely acknowledged for its role in various aspects of cancer progression, including cellular invasion, epithelial-mesenchymal transition, and immunosuppression. Immune checkpoint inhibitors (ICIs) and pharmacological agents that target TGF-β offer significant potential as therapeutic options for cancer. However, the specific role of TGF-β in prognostic assessment and treatment strategies for breast cancer (BC) remains unclear. Methods: The Cancer Genome Atlas (TCGA) database was utilized to develop a predictive model incorporating five TGF-β signaling-related genes (TSRGs). The GSE161529 dataset from the Gene Expression Omnibus was employed to conduct single-cell analyses aimed at further elucidating the characteristics of these TSRGs. Additionally, an unsupervised clustering algorithm was applied to categorize BC patients into two distinct groups based on the five TSRGs, with a focus on immune response and overall survival (OS). Further investigations were conducted to explore variations in pharmacotherapy and the tumor microenvironment across different patient cohorts and clusters. Results: The predictive model for BC identified five TSRGs: FUT8, IFNG, ID3, KLF10, and PARD6A. Single-cell analysis revealed that IFNG is predominantly expressed in CD8+ T cells. Consensus clustering effectively categorized BC patients into two distinct clusters, with cluster B demonstrating a longer OS and a more favorable prognosis. Immunological assessments indicated a higher presence of immune checkpoints and immune cells in cluster B, suggesting a greater likelihood of responsiveness to ICIs. Conclusion: The findings of this study highlight the potential of the TGF-β signaling pathway for prognostic classification and the development of personalized treatment strategies for BC patients, thereby enhancing our understanding of its significance in BC prognosis.
Antiplatelet and anticoagulation use and risk of bleeding from percutaneous dilatational tracheostomy insertion: Systematic review and meta-analysis
Authors: Brown Mark , Elsawy Fayez , Allison Benjamin , McGrath Brendan 
Published: February 2025

Introduction: Antiplatelet and anticoagulation therapies are frequently required in acutely unwell patients and confer an increased propensity for procedural bleeding. During percutaneous tracheostomy insertion, the decision to stop these therapies is left to clinical decision-makers. This meta-analysis summarises the risk of bleeding associated with antiplatelet and anticoagulation therapy during percutaneous tracheostomy insertion. Method: We conducted a systematic review and meta-analysis of studies which reported intraoperative bleeding during percutaneous tracheostomy while on single antiplatelet therapy (SAPT) or dual antiplatelet therapy (DAPT), as well as therapeutic anticoagulation (TAC). Groups were compared against those with prophylactic or no anticoagulation. Studies were pooled using random effects via the inverse variance method. Results: Four databases found 22 eligible studies, of which 14 studies presented data for meta-analysis representing 3,485 percutaneous tracheostomy insertion procedures. These included six studies that reported intraoperative bleeding outcome SAPT, six for DAPT and five for TAC. Overall, methodological quality was poor. No significant association was found for SAPT (Odds ratio 1.58; 95% confidence interval 0.72–4.41); P = 0.25; I2 = 81%) and TAC (OR 1.79; 95% CI 0.58–5.56; P = 0.35; I2 = 35%). The DAPT group was associated with increased bleeding with an OR of 2.05 (95% CI 1.18–3.56; P = 0.01; I2 = 0%). Conclusion: Our study supports temporarily withholding DAPT or TAC (if clinically feasible) to minimize bleeding risks associated with percutaneous dilatational tracheostomy.
Understanding the experience of persons living with chronic abdomino-pelvic pain: A cross-sectional nationwide survey
Authors: Manko Kelsey , Ajewole Christana O. , Lewis Hannah , Barish Stefanie , Lamvu Georgine 
Published: February 2025

Background: Few studies describe the healthcare expectations and experiences of persons living with chronic pelvic pain (CPP), despite its prevalence. Objectives: To describe pain symptoms, impact, interference with quality of life, treatment goals, treatments tried, and satisfaction with treatments and healthcare professionals among persons with CPP and determine whether these characteristics vary by pain duration (<6 months vs. ⩾6 months). Design: Cross-sectional population survey. Methods/Participants/Setting: Survey distributed to US persons ⩾18 years old. Results: Of 1,118 completed respondents, 69.8% ( n = 780) reported abdominal/pelvic pain and a pain level ⩾2 on a 0–10 scale. Of those, 122 respondents had pelvic pain lasting <6 months, while 658 had pain ⩾6 months (categorized as having CPP.) Compared to those with pain <6 months, persons with CPP were more likely to have severe pain that interfered with relationships ( p = 0.001), sleep ( p = 0.042), enjoyment of life ( p = 0.004), mood ( p = 0.019), and normal daily activity ( p=0.035). They were more likely to have pain that impacted sexual function ( p = 0.001) and ability to raise a family ( p = 0.035) and were more likely to report receiving conflicting information from healthcare professionals (HCPs) ( p = 0.001). In both groups, few were satisfied (very—somewhat satisfied categories combined) with care (34.9% vs. 38.6%, p = 0.332) and treatment (33.9% vs. 27.1%, p = 0.355). Limitations: Survey with close-ended questions. Conclusion: Individuals with abdomino-pelvic pain, particularly those with chronic pain, experience significant pain and disability, but many report receiving inadequate treatment or unsatisfactory care. This suggests there is still a need for improved healthcare services that address the unique needs of this population.
Credibility of Blood Flow Restriction Training in Patients With Knee Osteoarthritis: A Systematic Review and Meta-analysis
Authors: He Jinrong , Zhang Lei , Wu Quanshuo , Zhang Jialin 
Published: February 2025

Background: The effectiveness and practicality of blood flow restriction training (BFRT) as a nonsurgical intervention for treating patients with knee injuries are uncertain because of the small size of BFRT trials and inconsistent results. Purpose: To conduct a meta-analysis comparing the effectiveness of BFRT versus traditional resistance training in patients with knee osteoarthritis (OA) in terms of pain, muscle strength, functional performance, self-reported function, muscle size, and adverse events during exercise. Study Design: Systematic review; Level of evidence: 1. Methods: Under the PRISMA (Preferred Reporting Items for Systematic Reviews and Meta-Analyses) guidelines, we searched the Web of Science, PubMed, EMBASE, and other databases for randomized controlled trials of BFRT interventions in patients with knee OA. Methodological and quality evaluations, heterogeneity analysis, and subgroup analysis of the included studies were conducted, and effect sizes were evaluated using mean differences or standardized mean differences (SMDs). Subgroup and sensitivity analyses were used to explore the sources of heterogeneity. Results: Of 2826 initial studies, 6 studies (N = 228 patients) were included. The results of the meta-analysis indicated that compared with resistance training, BFRT did not significantly affect pain relief (SMD, −0.02 [95% CI, −0.30 to 0.26]; P = .88), muscle strength (SMD, 0.32 [95% CI, −0.33 to 0.96]; P = .33), functional performance (SMD, 0.25 [95% CI, −0.29 to 0.80]; P = .36), or self-reported function (SMD, −0.252 [95% CI, −0.88 to 0.45]; P = .52). However, BFRT reduced the risk of adverse events (risk ratio, 0.45 [95% CI, 0.20 to 1.01]; P = .05). Subgroup analysis revealed that compared with low-load resistance training, BFRT significantly increased muscle size (SMD, 0.88 [95% CI, 0.09 to 1.68]; P = .02). The quality-of-evidence assessment indicated that the evidence level for the above outcomes was low and that the strength of the recommendation was weak. Conclusion: The results of our meta-analysis indicated that compared with resistance training, BFRT did not significantly improve symptom outcomes in patients with knee OA. It is important to acknowledge that the findings were limited by the small number of studies and sample sizes that were included.
Kinematic Parameters Associated With Elbow Varus Torque in Elite Adult Baseball Pitchers
Authors: McCutcheon Thomas W. , Slowik Jonathan S. , Fleisig Glenn S. 
Published: February 2025

Background: Numerous studies have investigated pitching kinematics associated with elbow varus torque, but these studies were limited in the parameters analyzed and/or the number of pitchers tested. Purpose/Hypothesis: The purpose of this work was to evaluate numerous kinematic parameters in a large sample of elite adult pitchers. It was hypothesized that several kinematic parameters would be associated with variations in elbow varus torque. Study Design: Descriptive laboratory study. Methods: A deidentified biomechanical database of 523 pitchers (425 professional; 98 collegiate) was analyzed. For each pitcher, 21 kinematic parameters and normalized elbow varus torque (% body weight × height) were calculated. A stepwise multivariate linear regression model evaluated significant findings. In addition, biomechanical differences were identified between the high- and low-torque groups using Mann-Whitney U tests. Results: Forty percent of the variance in normalized torque was explained by 11 kinematic parameters. Comparison of the high- and low-torque groups demonstrated significant differences in 10 of these parameters (all except pelvic angular velocity). Compared with the low-torque group, the high-torque group had greater ball velocity, shoulder abduction at foot contact, elbow flexion at foot contact, maximum knee extension velocity during arm acceleration, maximum elbow extension velocity during arm acceleration, and trunk contralateral tilt at ball release. In addition, the high-torque group had lower upper trunk tilt at foot contact, shoulder external rotation at foot contact, maximum external rotation, and shoulder abduction at ball release. Conclusion: Normalized elbow varus torque was associated with ball velocity and 10 other kinematic parameters. Ball velocity and 9 of these kinematic parameters were significantly different between the high-torque and low-torque groups. These parameters may be related to increased pitch velocity but also increased load within the throwing elbow. Clinical Relevance: This study provides pitchers, coaches, and trainers with objectives for modification of pitching mechanics to reduce elbow torque and possible risk of injury, particularly kinematics in the early phase of the pitching motion.
Successful management of catheter injury or refractory infection by partial replantation of peritoneal dialysis catheters: a retrospective observational study
Authors: Ryou Seyoung , Ko Eun Jeong , Park Hoon Suk , Chung Byung Ha , Park Cheol Whee , Yang Chul Woo , Kim Yong-Soo , Kim Hyung Duk , Kim Yaeni 
Published: February 2025

Abstract

Background
The revised 2023 guidelines from the International Society for Peritoneal Dialysis (ISPD) emphasize salvage methods for treating refractory catheter-related infections, or mechanical catheter damage. This approach preserves the existing catheter by manipulating only the outer cuff above the peritoneum, avoiding hemodialysis transfer. We investigated the effectiveness of the partial replantation technique.

Methods
In this retrospective single-center study (January 2021 - December 2023), outcomes for nine patients undergoing salvage methods were compared with 58 patients receiving de novo catheter insertion. We assessed exit-site infection (ESI), tunnel infection (TI), peritonitis, and catheter dysfunction. The salvage method entailed distal cutting of the impaired catheter and attaching a new segment using a connector with a PD adaptor and transfer set.

Results
Nine patients (four males, mean age 56 years, average PD duration 66 months) employed the salvage method. Post-procedure, one patient (11.1%) reported ESI, one (11.1%) experienced TI, three (33.3%) developed peritonitis, and two (22.2%) required catheter removal. No procedural complications or catheter dysfunctions were observed. In the control group, ESI occurred in six patients (10.3%), TI in one (1.7%), peritonitis in 11 (19.0%), catheter removal in seven (12.1%), and catheter dysfunction in one (1.7%). Kaplan-Meier analysis showed no statistical difference between the groups: ESI (p = 0.306), TI (p = 0.094), peritonitis (p = 0.838), catheter dysfunction (p = 0.694), and catheter removal (p = 0.393).

Conclusions
This study supports the non-inferiority and effectiveness of the salvage method compared to de novo insertion in managing ESI or TI and mechanical catheter damage.