bluuebunny/crossref_metadata_2025_split huggingface dataset:
Catalase expression is an independent prognostic marker in liver hepatocellular carcinoma
Authors: Chen Yu-Chia , Chen Hsin-Hung , Chen Po-Ming 
Published: January 2024

Abstract

Objectives
Liver hepatocellular carcinoma (LIHC) is the most common type of primary liver cancer and originates from hepatocytes, the main functional cells of the liver. It is a serious and aggressive cancer with a generally poor prognosis, especially when diagnosed at advanced stages. Reactive oxygen species (ROS) have been detected in LIHC and are involved in carcinogenesis and tumor progression. Here, a comprehensive analysis was performed to evaluate the effects of ROS-related genes on the prognosis of LIHC.

Methods
Using bioinformatical tools including Gene Expression Profiling Interactive Analysis (GEPIA2) and Q-omics, a comprehensive analysis was performed to evaluate the effects of ROS-related genes, including superoxide dismutases (SODs), glutathione peroxidases (GPXs), peroxiredoxins (PRDXs) and catalase (CAT) on the prognosis of LIHC using The Cancer Genome Atlas (TCGA) dataset and identified the most appropriate candidate genes. Then we further explored their effects on LIHC cell proliferation and drug selection for LIHC treatment.

Results
We found that CAT expression was significantly downregulated in late stage’s LIHC tissues compared to normal liver or early stage’s LIHC tissues, and high CAT expression was correlated with a favorable survival prognosis in LIHC. The expression of the CAT gene was associated with an inhibition of the “cell cycle” pathway. HepG2 and Hep3B cells’ growth was increased with a decrease in CAT expression by silencing its mRNA. As silencing of CAT in HepG2 and Hep3B cells, and its association with an increase in the expression of PLK1, CCNB1, CDC20, and PTTG1. A comparative 426 drug response in LIHC cells with different CAT expression, SU11274, a Met inhibitor, could serve as a therapeutic option when CAT levels are low in LIHC cells.

Conclusions
Our findings revealed that Met inhibitors could potentially control tumor progression and be used as a therapeutic option against LIHC with low CAT.
Hydrogen as an energy carrier: constraints and opportunities
Authors: Armaroli Nicola , Bandini Elisa , Barbieri Andrea 
Published: January 2024

Abstract
The use of molecular hydrogen (H2) in the energy sector faces several technical and economic hurdles related to its chemical and physical properties, particularly volumetric energy density and mass. The production, transport and storage of hydrogen, both in gas and liquid form, are intrinsically inefficient and expensive. Moreover, the mass production of green hydrogen would preferably use surpluses of renewable electricity that will be largely available not before the next decade. To fulfill the great potential of H2 in the decarbonization of the global economy – which should greatly accelerate – applications must be carefully selected, favoring for instance hard-to-abate sectors with respect to low-temperature residential heating or long-distance transportation versus light duty vehicles. In the meantime, research on production, transportation and storage of H2 must substantially leap forward.
Genesis, Features and Prospects for the Development of Digital Fashion
Authors: Biliakovych Liana , Derman Lilia , Oborska Svitlana , Naumenko Oksana , Vovk Alina 
Published: January 2024

Abstract
In the modern world, the fashion industry is constantly evolving, and digital technologies are having an increasingly significant impact on its development. Therefore, the research relevance is determined by the need to explore the features of modern digital fashion concerning the commercial aspect, ethical issues and concept of sustainable fashion. This research aims to predict the prospects for the development of digital fashion in the fashion and design industry, and is based on the following methods: analytical, comparative, generalisation and systematisation methods. The study results showed that digital fashion is becoming increasingly popular among well-known brands, designers and fashion houses, while the commercial use of digital fashion is expanding thanks to the non-fungible token (NFT) platform and other digital tools. At the same time, the research also identifies ethical issues related to the protection of intellectual property in digital reality. Furthermore, the research analyses the segmentation of the digital fashion market and forecasts the development of this industry until 2030 and beyond. In terms of the relationship with the concept of sustainable fashion, it is found that digital fashion can contribute to sustainable development by reducing the use of physical resources and preserving the environment.
EDITORIAL
Authors: Iriondo Otero Walter R. , Martins Rodriguez Alejandro , Dos Santos Franz Luis Antônio 
Published: January 2024

Temos imenso prazer em apresentar a Edição Especial da Revista Prociências, intitulada “A revolução da indústria 4.0: transformando desafios em oportunidades”, que objetiva divulgar resultados de investigações científicas e aplicações práticas na área da Indústria 4.0.
Nesse contexto, é necessário agradecer a confiança depositada na Revista Prociências pelas instituições que organizaram a presente Edição Especial, ao escolher a nossa Revista como veículo para oferecer aos leitores do nosso periódico científico um conjunto seleto de artigos que refletem resultados significativos de estudos na área em tela.
Notadamente, agradecer ao Núcleo de Estudos Aplicados em Indústria 4.0 e aos docentes e discentes do Curso de Engenharia de Produção da UFPel; ao Programa de Pós-Graduação em Sistemas e Processos Industriais da UNISC; ao Programa de Pós-graduação em Engenharia Têxtil da UFSC, campus Blumenau; ao Curso de Engenharia de Produção da UNIPAMPA, campus Bagé; e ao Programa de Pós-Graduação em Tecnologia Ambiental da UNISC; à Rede RS Indústria 4.0; e à UFRGS.
Desejo parabenizar os autores e autoras dos artigos que compõem esta Edição Especial e expressar meu reconhecimento ao trabalho realizado pela equipe envolvida na Coordenação desta Edição da Revista, cuja determinação foi decisiva para a organização dos trabalhos.
Resta mencionar que a Revista Prociências continua à disposição da comunidade científica internacional para publicação de outras Edições Especiais, no formato Dossiê ou Edição Temática; e que a Revista recebe contribuições em fluxo contínuo, ação que contempla a submissão, recebimento e avaliação de artigos durante o ano todo.
Aguardamos, portanto, o recebimento de propostas de novas Edições Especiais da Revista, assim com trabalhos inéditos para as próximas edições regulares do nosso periódico.
Desejamos a todos uma profícua leitura desta Edição Especial da Revista Prociências.
Aortabillentyű-beültetés antifoszfolipid szindrómában
Authors: Szántó Tamás , Béres Szabolcs , Husznai Róbert , Kiss Rudolf , Kellermayer Dalma , Tornóczki Tamás , Hejjel László 
Published: January 2024

EsetismertetésEgy 44 éves férfi betegnél endokarditisz talaján kialakult súlyos aortabillentyű-elégtelenség tett szükségessé szívsebészeti beavatkozást. A kevesebb mint egy év alatt bekövetkezett többszöri trombotikus esemény felvetette antifoszfolipid szindróma lehetőségét. A lupus antikoaguláns pozitivitás és az említett klinikai kép ezt igazolta.MegbeszélésBetegünk fiatal életkora és a biológiai műbillentyű korlátozott élettartama ellenére biológiai műbillentyű beültetése mellett döntöttünk. Választásunkat azzal indokoljuk, hogy tanulmányok bizonyítják antifoszfolipid szindrómás betegeknél a mechanikus műbillentyűvel összefüggésbe hozható thromboembolia viszonylag gyakori előfordulását. A műtétet szövődménymentesen elvégeztük, aktivált parciális thromboplastin idővel kontrollált Na-heparin korai adása mellett állítottuk be az orális antikoaguláns terápiát 3,0 INR célértékkel a műtét utáni ötödik napra. A műtét során eltávolított billentyűből korokozó nem tenyészett ki. A kórszövettani vizsgálat abakteriális endokarditiszt véleményezett, nem kizárva a korábbi fertőzést. Biológiai műbillentyű implantáció után három hónapig ajánlott aszpirin vagy K-vitamin antagonista adása, betegünk esetében viszont élethosszig tartó antikoaguláns kezelés szükséges, tekintettel rendszerbetegségére.KövetkeztetésHalmozódó tromboembóliás események kapcsán gondolni kell antifoszfolipid szindrómára, mely igazolása adott esetben meghatározhatja a választható műbillentyű fajtáját. Az ajánlások legtöbbször csak általánosságban fedik le a ritka társbetegségeket, ezért a kapcsolódó szakirodalom áttekintése is szükséges az optimális, betegre szabott döntéshez.
Ortaokul Düzeyinde Kullanılan Müzik Ders Kitapları ve İçerik Yönünden İncelenmesi: (Türkiye, İngiltere ve İtalya Örneği)
Authors: ÇELİK Şevval , ÖZAYDIN Nilay , BARIŞERİ AHMETHAN Nurtuğ 
Published: January 2024

Bu araştırma, Türkiye, İngiltere ve İtalya’da ortaokul düzeyinde kullanılan müzik ders kitaplarını içerik bakımından karşılaştırmalı olarak incelemeyi ve değerlendirmeyi amaçlamaktadır. Araştırmada veriler “doküman analizi” ile elde edilmiş, verilerin analizinde içerik analizi tekniği kullanılmıştır. Araştırmanın evrenini, 2020- 2021 öğretim yılında Avrupa ülkeleri ile bu ülkelerde okutulan 6, 7 ve 8. sınıf müzik ders kitapları; örneklemini ise Türkiye, İngiltere ve İtalya ile 2020- 2021 öğretim yılında 6, 7 ve 8. sınıflarda okutulan seçilmiş sekiz kitap oluşturmaktadır. İngiltere ve İtalya ortaokul müzik ders kitapları İngilizce- İtalyanca dillerinden Türkçe’ ye tercüme edilmiştir.
Yapılan incelemede, Türkiye ve İngiltere’de kullanılan ders kitaplarında müzik teorisi konusu benzerlik göstermektedir. İngiltere’de, film müziklerine, İtalya’da enstrümanları tanımaya. Türkiye’de ise temel müzik eğitimi konularına yer verildiği görülmektedir. Bununla birlikte üç ülkenin her millete ait kültürel mirası içinde barındıran konuların, ezgi ve ritim yaratma bölümlerinin benzer olduğu bulgusuna ulaşılmıştır. Türkiye ders kitaplarında daha çok müziksel bilgilenme alanına ait etkinliklerin olduğu; müziksel çalma ve çalgısal seslendirme temalı etkinliklere daha az yer verildiği saptanmıştır. Bu anlamda Türkiye’de müzik dersine tanınan süre arttırılabilir. Bu sürenin arttırılması çalgı eğitimine de yeterli zamanın ayırılmasına, derste daha çok etkinlik yapılmasına ve derslerin verimli işlenmesine katkı sağlayacaktır.
El sistema de transporte del área metropolitana de Buenos Aires frente a las políticas neoliberales. 30 años después
Authors: Redondo Solange Paula 
Published: January 2024

Los sistemas de transporte son en las ciudades actuales, un elemento clave para garantizar el derecho a la ciudad y a la movilidad, porque la expansión de las grandes áreas metropolitanas obliga a un alto porcentaje de la población a desplazarse para acceder a los bienes y servicios que necesitan. Las políticas neoliberales implementadas en la Argentina desde mediados de 1970, tuvieron un fuerte impacto en el transporte urbano, que pasaron de ser provistos por el estado, al sector privado. Esto cambió la lógica de provisión y manejo de los servicios de trasportes del Área Metropolitana de Buenos Aires, ya que las empresas priorizan sus ganancias, entonces se redujeron miles de km de vías férreas y el deterioro del autotransporte: reducción de las frecuencias, los recorridos y la calidad de las unidades de traslado y el incremento constante de los precios de las tarifas.
Identification Of Misconceptions Of Eighth Grade Students On Light Materials And Optical Devices
Authors: Firansilady Amanah , Siahaan Sardianto Markos , Syuhendri Syuhendri 
Published: January 2024

This study is a descriptive study that aims to analyze the understanding of the concept of students in science subjects on the material of light and optical devices as well as the causes of student misconceptions. This study was conducted on VIII grade students in SMP Negeri 5 Palembang. The subjects of this study were 100 eighth grade students in SMP Negeri 5 Palembang. The instrument used is a set of diagnostic tests consisting of 10 items of questions from physpot which has been translated and tested for validity. Data retrieval method is done by providing a test of understanding the concept of multiple choice questions as many as 10 items equipped with CRI (Certainty if Response Index) with a scale (0-5). In this study it was found that the average score obtained by students from the test is quite low at 50%. In addition, 9.28% had misconceptions, 38.5% did not understand the concept, and 28.5% had understood the concept. Some of the findings identified misconceptions include: (1) only white objects that can reflect light in a dark room, (2) points near the eyes of patients with hypermetropy, (3). light propagates about transparent objects and (4). light reflected from smooth surfaces.
Analisis Kebutuhan Pengembangan E-Modul Terintegrasi 4C sebagai Implementasi Indikator Ketercapaian Utama Kelas Kolaboratif dan Partisipatif
Authors: Anggreini Anggreini , Permadi Dimas , Nurulsari Novinta 
Published: January 2024

Proses pelaksanaan dan penilaian mata kuliah Metodologi Penelitian Pendidikan (MPP) sudah mengikuti program MBKM yang dirancang untuk memenuhi IKU 7. Namun pelaksanaannya dinilai belum optimal untuk Capaian Pembelajaran Mata Kuliah (CPMK) MPP. Tujuan dari penelitian ini adalah untuk mengetahui keadaan dan kebutuhan mahasiswa calon guru fisika saat melaksanakan pembelajaran di kelas kolaboratif dan partisipatif. Serta menganalisis materi dan tugas untuk mencapai CPMK MPP. Penelitian ini menggunakan metode deskriptif analitis dengan instrumen penelitian berupa kuesioner yang disebarkan secara online dengan bantuan google form. Sampel dalam penelitian ini adalah 58 mahasiswa calon guru Program Studi Pendidikan Fisika Universitas Lampung. Hasil penelitian menunjukkan bahwa mahasiswa sudah memiliki kemampuan untuk berkomunikasi serta berkolaborasi dalam tugas kelompok, namun baru sebagian kecil yang memiliki kemampuan berpikir kritis dan kreatif jika menyelesaikan suatu permasalahan kasus penelitian pendidikan. Selain itu mahasiswa masih kurang berpartisipasi aktif saat diskusi kelas, dikarenakan kurangnya pemahaman akan materi yang dibahas. Hal ini disebabkan oleh belum tersedianya bahan ajar dan media pembelajaran yang tersusun secara sistematis sesuai dengan CPMK, study kasus yang dibahas bukan contoh penelitian pendidikan. Analisis materi dan tugas yang dikembangkan diperoleh rincian lima bab yang dicapai untuk enam sub-CMPK MPP. Berdasarkan hasil analisis kebutuhan ini, dosen perlu mengembangkan bahan ajar dan media pembelajaran berupa modul digital yang terintegrasi dengan keterampilan abad-21, yaitu critical thinking, collaboration, creativity, dan communication guna mendukung tercapaikan IKU 7 program MBKM.
Analisis Produktivitas Alat Angkut dan Muat Pada Pengupasan Overburden di PT. XYZ Desa Batuah, Kutai Kartanegara, Kalimantan Timur
Authors: Lestari Putri Indah , Farist Ahsinlana Dzikrorrohman 
Published: January 2024

PT. XYZ is a company engaged in coal mining contractors located in East Kalimantan. During mining activities, PT. XYZ uses an open-pit mining system. In February 2023 PT. XYZ had a production target overburden of 193,700 bcm, but in reality, the production target only reached 119,529 bcm.. The productivity of the conveyance and loading equipment is by field conditions to be compared with the company's production achievement targets. The research method used is a quantitative method where this research takes data directly and interviews in the field. The results of the calculation analysis, the production of means of conveyance dumptruckIVECO 350 reached 27.17 Bcm/hour, dump truck ISUZU GIGA FV285 reached 22.16 Bcm/hour, andarticulated dump truck VOLVO A40G achieved 54.57 Bcm/hr. Production of the Sanny SY330H excavator truck reached 178.63 Bcm/hour and the XCMG X370CA excavator reached 154.09 Bcm/hour. The amount of production of the actual means of conveyance that was achieved was 193,700 Bcm/hour. The parameters that affect the amount of production of a tool both hauling and loading, namely circulation time, tub or bucket capacity, amount of filling, fill factor, and material expansion factor. However, based on field observations by the author, there are several additional factors such as the type of weather factor and the condition of the mine road or ramp. In addition to the weather factor, road conditions that are far from the existing standard size will affect the amount of production of a tool.
Keywords: coal, Overburden, Production, productivity
Pengaruh Pengaruh Penggunaan Metode Aachen Assisted Leaching Pada Pelindian Emas Di Balai Besar Pengujian Mineral Dan Batubara Tekmira
Authors: Lestari Zan Adinda Puspita Tri , Mirahati Riria Zendy 
Published: January 2024

Balai Besar Pengujian Mineral dan Batubara tekMIRA merupakan badan layanan umum masyarakat yang menangani pengujian mineral dan batubara. Lembaga penelitian ini bergerak berdasarkan keinginan dari pelanggan. Salah satu project yang dilakukan adalah menguji persen ekstraksi bijih emas sulfida dengan menggunakan metode Aachen Assissted Leaching (AAL). Penggunaan metode ini dilakukan sebelum proses pelindian atau yang dikenal dengan proses pre-treatment pelindian emas. Proses ini menggunakan reaktor Aachen, kinerja dari reaktor ini adalah dengan meningkatkan kadar oksigen terlarut atau Dissolved Oxygen (DO) sebanyak 20-30%. Kandungan mineral pengikut pada bijih emas sulfida seperti silika dan sulfur akan mengakibatkan proses pelindian tidak optimal karena sulit dihilangkan tanpa pre-treatment khusus. Cara kerja kadar oksigen terlarut pada pre-treatment ini adalah dengan mengikis lapisan film fluida pengotor. Semakin menipis lapisan film fluida pengotor akan menjadikan reaksi sianidasi pada proses pelindian semakin cepat sehingga dapat meningkatkan persen ekstraksi pelindian emas. Sebagai pembanding didapatkan juga sample Basecase yang merupakan slurry bijih emas yang tidak dilakukan pre-treatment Aachen Assisted Leaching (AAL). Penggunaan Aachen Assissted Leaching (AAL) dapat memberikan alternatif sebagai metode pre-treatment pelindian emas yang optimal, hal tersebut ditunjukkan hasil persen ekstraksi pada sample Aachen Assissted Leaching (AAL) mencapai 98%. Hasil tersebut memiliki perbedaan yang cukup tinggi dengan sample Basecase dengan persen ekstraksi 93%.
From Farms to Pharma: A “Natural” History of Vaccine Production and Vaccine Skepticism
Authors: Lanzarotta Tess 
Published: January 2024

In the era of synthetic biology, vaccine skeptics have made claims that vaccines are “unnatural,” that the technology used to develop them is risky and untested, and that “naturally acquired” immunity is superior to vaccination. Public health practitioners and physicians alike have attempted to respond to these concerns by reminding patients and the public that vaccines generate a “natural” immune response. These negotiations over the language to describe vaccines are nothing new. This article puts the relationship between vaccines and concepts like “nature” and “natural” in historical perspective. In the mid- to late 19th century, the smallpox vaccine, then the only vaccine available, was propagated on farms. Vaccine farmers—usually enterprising physicians—kept herds of cattle infected with cowpox, cultivating the virus “stock” from which the vaccine was derived. By exploring how vaccine farmers established and maintained public confidence in their products, we can see that debates over vaccine safety have always involved concerted efforts to persuade the public to place their trust in technologies that might at first seem novel, strange, or even dangerous. More broadly, this article encourages readers to think about the shifting valences of the category “natural,” particularly in a public health context. ( Am J Public Health. 2024;114(2):193–201. https://doi.org/10.2105/AJPH.2023.307508 )
Clinker Slurry for Cementing Across Salt Formations
Authors: Huang Hongfei , Wang Chunyu , Yao Xiao , Geng Chenzi 
Published: January 2024

Summary
Potassium chloride (KCl) is more effective in preventing salt layer dissolution than sodium chloride (NaCl) while cementing across salt formations. This paper studied the effect of KCl on the properties of cement slurry and found that KCl worsened the flowability of cement slurry. Experimental evidence confirmed that an alkaline environment promoted the dissolution of gypsum, leading to its reaction with KCl to produce syngenite. A large amount of needle-shaped syngenite caused the cement slurry to lose flowability. In addition, silica flour slurry was designed to prove the formation of syngenite and the effect of syngenite on the rheological property of the slurry. In a new way, clinker was used to prepare slurry containing KCl to prevent the generation of syngenite. The effect of KCl on the properties of clinker slurry was evaluated. The dissolution experiment of halite in clinker slurry filtrate proved that KCl had a strong ability to inhibit the dissolution of halite.
Effects of Drilling Number and Distribution on Fracture Using the Pulse Plasma on Tight Sand Reservoir
Authors: Li Zhaoxuan , Wang Shuo , Pan Yi , Zhang Rongqi , Chen Jiajun 
Published: January 2024

Summary
The permeability of unconventional reservoirs is extremely low, resulting in their drainage area being limited to tens of feet. Therefore, researchers have developed an effective stimulation technology that can be used in combination with conventional hydraulic fracturing, namely, pulsed plasma fracturing technology. Pulsed plasma fracturing technology is an efficient and environmentally friendly auxiliary hydraulic fracturing stimulation technology. However, most existing studies have focused only on the effect of pulsed plasma fracturing on single wells, ignoring the effect of the number and distribution of wells drilled on pulsed plasma fracturing. In this paper, pulsed plasma fracturing is studied by a self-built pulsed plasma experimental platform and nonlinear finite element software. First, the generation and propagation mechanism of shock wave, fracture type, and stress field analysis of rock mass in pulsed plasma fracturing technology are discussed. The double-well experiment was carried out by using the experimental platform, and the fracture law of fractures under different wellhead distribution conditions was obtained. In addition, a multiwell mathematical model is established by using the combination of the Euler method and Lagrange method to simulate the interaction between fluid and solid, that is, arbitrary Lagrangian Eulerian (ALE) multimaterial fluid-solid coupling method and the influence of drilling times and wellhead distribution on pulsed plasma fracturing is discussed. Stress analysis shows that the rock is mainly affected by ground stress, liquid column pressure, and shock wave pressure. The experimental results show that the discharge voltage is positively correlated with the shock wave pressure on the rock. The distribution of different wellheads affects the distribution and length of fractures. The double-well experiment makes the fractures easier to fracture. The simulation results show that the fracture length in the connection direction of the two wells is longer, and the fracture length in the vertical direction is shorter. This shows that the number and distribution of drilling affect the initiation and propagation of fractures.