bluuebunny/crossref_metadata_2025_split huggingface dataset:
Ethnic Differences in Parent Preference to Be Present for Painful Medical Procedures
Authors: Jones Melissa , Qazi Mohammed , Young Kelly D. 
Published: August 2005

Objective. To examine ethnic differences between white, black, and Hispanic (English-speaking and Spanish-speaking) parents in their desire to remain present during their children’s painful medical procedures.Methods. A convenience sample of parents from each of 4 ethnic groups (black, white, and Hispanic [divided into English-speaking Hispanic and Spanish-speaking Hispanic]) was surveyed regarding their preferences for remaining present for 5 hypothetical painful procedures: venipuncture, laceration repair, lumbar puncture, fracture reduction, and critical resuscitation. For each procedure, a short description of the procedure was read to the parent, and a picture of the procedure was shown. The effect of ethnicity on parental desire to stay was examined by using the χ2 test and multivariate logistic regression.Results. Complete data on 300 parents, 72 to 79 from each ethnic group, were obtained. There were no significant demographic differences between groups except that English-speaking Hispanic parents were younger, and black parents were relatively well educated, whereas Spanish-speaking Hispanic parents were relatively less well educated. Overall, the percentages of those who would wish to remain with their child during the procedures were 94% (venipuncture), 88% (laceration repair), 81% (lumbar puncture), 81% (fracture reduction), and 81% (critical resuscitation). The only significant ethnic difference was that English-speaking Hispanic parents were less likely to want to remain present during a critical resuscitation (P = .01). Black parents were less likely, and English-speaking Hispanic parents were more likely, to want physicians to decide for them whether they should remain present. Parents generally preferred to actively participate during the procedure by coaching and soothing their child rather than to just observe.Conclusions. We found few ethnic differences in parents’ desire to be present during their child’s painful medical procedures. Overall, the vast majority of parents would prefer to remain present even for highly invasive procedures.
Growth Characteristics of Children With Ectodermal Dysplasia Syndromes
Authors: Motil Kathleen J. , Fete Timothy J. , Fraley J. Kennard , Schultz Rebecca J. , Foy Thomas M. , Ochs Ulrike , Sybert Virginia P. 
Published: August 2005

Objective.Clinical observations suggested that growth abnormalities may be present in children with ectodermal dysplasia (ED) syndromes. This study characterizes the longitudinal pattern of growth in a cohort of children with the ED syndromes. We hypothesized that (1) linear and ponderal growth abnormalities are present in children with ED from infancy through adolescence, and (2) linear and ponderal growth abnormalities differ among the clinical variants of these disorders.Methods.We studied 138 children who had ED and were registered with the National Foundation for Ectodermal Dysplasias, 74% of whom had clinical features consistent with the hypohidrotic EDs (HEDs). Height (or length) and weight measurements were obtained by standardized techniques and from review of available medical records. We converted these measurements to weight-for-height (children younger than 5 years and &lt;103 cm in length) or BMI (children ≥2 years old). Height, weight, weight-for-height, and BMI were converted to age- and gender-specific z scores. We applied linear regression, 1-sample t tests, and analysis of variance to detect linear and ponderal growth abnormalities in children with ED compared with a reference population.Results.Mean weight-for-age, weight-for-height, and BMI-for-age z scores but not height-for-age z score, were significantly lower in children with the ED syndromes than in the reference population. Mean weight-for-age and weight-for-height z scores but not BMI-for-age or height-for-age z scores increased significantly with increasing age. The mean height-for-age z score of children with the ED syndromes other than the HEDs was significantly lower than that of children with the HEDs.Conclusions.Growth abnormalities, measured as weight deficits, were present at an early age in children with the ED syndromes and persisted through adolescence. Height deficits were seen only in children with ED syndromes other than HEDs. Clinicians should evaluate carefully children with ED syndromes for growth abnormalities.
In Vivo Study of the Inflammatory Modulating Effects of Low‐level Laser Therapy on iNOS Expression Using Bioluminescence Imaging
Authors: Moriyama Yumi , Moriyama Eduardo H. , Blackmore Kristina , Akens Margarete K. , Lilge Lothar 
Published: August 2005

ABSTRACTThis study was designed to demonstrate that bioluminescence imaging (BLI) can be used as a new tool to evaluate the effects of low‐level laser therapy (LLLT) during in vivo inflammatory process. Here, the efficacy of LLLT in modulating inducible nitric oxide synthase (iNOS) expression using different therapeutic wavelengths was determined using transgenic animals with the luciferase gene under control of the iNOS gene expression. Thirty transgenic mice, FVB/N‐Tg(iNOS‐luc)Xen, were allocated randomly to one of four experimental groups treated with different wavelengths (λ= 635, 785, 808 and 905 nm) or a control group (nontreated). Inflammation was induced by intra‐articular injection of zymosan A in both knee joints. Laser treatment (25 mW cm−2, 200 s, 5 J cm−2) was applied to the knees 15 min after inflammation induction. Measurements of iNOS expression were performed at various times (0, 3, 5, 7, 9 and 24 h) by measuring the bioluminescence signal using a highly sensitive charge‐coupled device (CCD) camera. The results showed a significant increase in BLI signal after irradiation with 635 nm laser when compared to the nonirradiated animals and the other LLLT‐treated groups, indicating wavelength dependence of LLLT effects on iNOS expression during the inflammatory process, and thus demonstrating an action spectrum of iNOS gene expression following LLLT in vivo that can be detected by BLI. Histological analysis was also performed and demonstrated the presence of fewer inflammatory cells in the synovial joints of mice irradiated with 635 nm compared with nonirradiated knee joints.
Reduction of Ribonucleosides to 2′‐Deoxyribonucleosides
Authors: Robins Morris J. , Wnuk Stanislaw F. 
Published: August 2005

AbstractRibonucleosides are converted into 2′‐deoxyribonucleosides in good yields by a four‐step procedure. Selective protection of the 3′‐ and 5′‐hydroxyl groups with 1,3‐dichloro‐1,1,3,3‐tetraisopropyl‐1,3‐disiloxane is followed by functionalization of the 2′‐hydroxyl group with phenoxythiocarbonyl chloride. Free radical–mediated reductive C2′–O2′ bond cleavage of these 3′,5′‐O‐TPDS‐2′‐O‐PTC‐nucleoside derivatives with tributyltin hydride, followed by removal of the silyl protecting group with tetrabutylammonium fluoride, provides the 2′‐deoxyribonucleosides. Adenosine, cytidine, guanosine, and uridine are converted into dA, dC, dG, and dU in overall yields of 60% to 80%. Use of tributyltin deuteride in the reductive cleavage step gives 2′‐deuterio‐2′‐deoxyadenosine in 81% yield from adenosine with >85% retention of configuration at C2′. Application of this four‐step protocol with nucleoside analogs is straightforward.
A low‐temperature heteronuclear NMR study of two exchanging conformations of metal‐bound pyoverdin PaA from Pseudomonas aeruginosa
Authors: Tzou Der‐Lii , Wasielewski Emeric , Abdallah Mohamed A. , Kieffer Bruno , Atkinson R. Andrew 
Published: August 2005

AbstractUnder iron‐deficient conditions, the Gram‐negative bacterium Pseudomonas aeruginosa ATCC 15692 secretes a peptidic siderophore, pyoverdin PaA, composed of an aromatic chromophore derived from 2,3‐diamino‐6,7‐dihydroxyquinoline and a partially cyclized octapeptide, D‐Ser–L‐Arg–D‐Ser–L‐FoOHOrn–(L‐Lys–L‐FoOHOrn–L‐Thr–L‐Thr) (FoOHOrn: δN‐formyl‐δN‐hydroxyornithine), in which the C‐terminal carboxyl group forms a peptidic bond with the primary amine of the L‐Lys side chain. Ferric iron is chelated by the catechol group on the chromophore and the two hydroxyornithine side chains. In aqueous solution, the 1H‐NMR spectrum of pyoverdin PaA–Ga(III), in which Ga(III) is used instead of Fe(III) for spectroscopic purposes, showed clear evidence of exchange broadening, preventing further structural characterization. The use of cryo‐solvents allowed measurements to be made at temperatures as low as 253 K where two distinct conformations with roughly equivalent populations could be observed. 13C and 15N labeling of pyoverdin PaA enabled complete assignment of both forms of pyoverdin PaA–Ga(III) at 253 and 267 K, using triple‐resonance multidimensional NMR experiments commonly applied to doubly labeled proteins. © 2005 Wiley Periodicals, Inc. Biopolymers 79: 139–149, 2005This article was originally published online as an accepted preprint. The “Published Online” date corresponds to the preprint version. You can request a copy of the preprint by emailing the Biopolymers editorial office at biopolymers@wiley.com
Development of a Novel Environmentally Friendly Electrolytic System by Using Recyclable Solid‐Supported Bases for In Situ Generation of a Supporting Electrolyte from Methanol as a Solvent: Application for Anodic Methoxylation of Organic Compounds
Authors: Tajima Toshiki , Fuchigami Toshio 
Published: August 2005

AbstractWe have successfully developed a novel environmentally friendly electrolytic system using recyclable solid‐supported bases for in situ generation of a supporting electrolyte from methanol as a solvent. It was found that solid‐supported bases are electrochemically inactive at an electrode surface. It was also found that solid‐supported bases dissociate methanol into methoxide anions and protons. Therefore, in the presence of solid‐supported bases, it was clarified that methanol serves as both a solvent and a supporting electrolyte generated in situ. Anodic methoxylation of various compounds with solid‐supported bases was carried out to provide the corresponding methoxylated products in good to excellent yields with a few exceptions. The methoxylated products and the solid‐supported bases were easily separated by only filtration, and the desired pure methoxylated products were readily isolated simply by concentration of the filtrates. The separated and recovered solid‐supported bases were recyclable for several times.
Asymmetric Total Synthesis of Fredericamycin A: An Intramolecular Cycloaddition Pathway
Authors: Akai Shuji , Tsujino Toshiaki , Fukuda Nobuhisa , Iio Kiyosei , Takeda Yoshifumi , Kawaguchi Ken‐ichi , Naka Tadaatsu , Higuchi Kazuhiro , Akiyama Emi , Fujioka Hiromichi , Kita Yasuyuki 
Published: August 2005

AbstractThe asymmetric total synthesis of the potent antitumor antibiotic fredericamycin A ((S)‐1) was achieved by the intramolecular [4+2] cycloaddition of the silylene‐protected styrene derivative (S)‐7 followed by the aromatic Pummerer‐type reaction of the sulfoxide (S)‐5. Although we had already succeeded in the total synthesis of racemic 1 by the same approach, synthesis of its asymmetric version was more complicated than we had expected due to the difficulties involved in constructing the quaternary carbon center and the tendency of this center to undergo facile racemization. Racemization of this center during the installation of the acetylene moiety on the dione (R)‐8 was the most serious aspect. Systematic studies of its DE‐ring analogue (R)‐25 revealed that racemization of the quaternary carbon center proceeded by a retro‐aldol–aldol reaction of the initial adduct, (1R)‐39 a‐Li, and that the degree of racemization was dependent on the reaction temperature. The racemization process could be completely depressed by keeping the reaction temperature at −78 °C. The construction of the stereogenic quaternary carbon center was achieved by the lipase‐catalyzed desymmetrization of the prochiral 1,3‐diol 9 a bearing the DEF‐ring moiety. These studies enabled us to attain the asymmetric total synthesis of (S)‐1 while completely retaining the chiral integrity created by the enzymatic reactions.
Configurational Stability of Bisindolylmaleimide Cyclophanes: From Conformers to the First Configurationally Stable, Atropisomeric Bisindolylmaleimides
Authors: Barrett Simon , Bartlett Stephen , Bolt Amanda , Ironmonger Alan , Joce Catherine , Nelson Adam , Woodhall Thomas 
Published: August 2005

AbstractThe bisindolylmaleimides are selective protein kinase inhibitors that can adopt two limiting diastereomeric (syn and anti) conformations. The configurational stability of a range of substituted and macrocyclic bisindolylmaleimides was investigated by using appropriate techniques. With unconstrained bisindolylmaleimides, the size of the 2‐indolyl substituents was found to affect configurational stability, though not sufficiently to allow atropisomeric bisindolylmaleimides to be obtained. However, with a tether between the two indole nitrogen atoms in place, the steric effect of 2‐indolyl substituents was greatly exaggerated, leading to large differences in configurational stability. The rate of interconversion of the syn and anti conformers varied by over twenty orders of magnitude through substitution of a bisindolylmaleimide ring system, which was constrained within a macrocyclic ring. Indeed, the first examples of configurationally stable atropisomeric bisindolylmaleimides are reported; the half‐life for epimerisation of these compounds at room temperature was estimated to be >107 years.
Palladium‐Catalyzed Suzuki—Miyaura Coupling Reactions Involving β,β‐Dihaloenamides: Application to the Synthesis of Disubstituted Ynamides.
Authors: Couty Sylvain , Barbazanges Marion , Meyer Christophe , Cossy Janine 
Published: August 2005

AbstractFor Abstract see ChemInform Abstract in Full Text.
Synthesis of New 3‐Phenoxypropan‐2‐ols with Various Heterocyclic Substituents.
Authors: Mesropyan E. G. , Ambartsumyan G. B. , Avetisyan A. A. , Galstyan A. S. , Arutyunova I. R. 
Published: August 2005

AbstractFor Abstract see ChemInform Abstract in Full Text.
Reaction of α‐Methylstyrene with Arylsulfonyl Chlorides: Spontaneous Dehydrochlorination Against the Zaitsev Rule.
Authors: Ermolaeva Valentina V. , Gerasimova Nina P. , Nozhnin Nikolai A. , Moskvichev Yuri A. , Alov Eugeni M. , Danilova Angelina S. , Shutova Irina V. , Kozlova Olga S. 
Published: August 2005

AbstractFor Abstract see ChemInform Abstract in Full Text.
A Convenient Synthesis of Fluoroalkylated γ‐Butyrolactones from Polyfluoroalkyl Iodides and 4‐Pentenoic Acid Catalyzed by Pd(PPh3)4.
Authors: Xiao Fanhua , Wu Fanhong , Yang Xueyan , Shen Yongjia , Shi Xinmei 
Published: August 2005

AbstractFor Abstract see ChemInform Abstract in Full Text.
Reactivity of Amidinium Salts′ Access to Benzo[4,5]imidazo[2,1‐b]thiazoles
Authors: Sissouma D. , Adjou A. , Toure S. A. , Zoakouma S. , Gnon Baba , Tea G. C. 
Published: August 2005

AbstractFor Abstract see ChemInform Abstract in Full Text.
Chemistry of 3‐Hetarylcoumarins. Part 2. 3‐(2‐Thiazolyl)coumarins.
Authors: Khilya O. V. , Shablykina O. V. , Frasinyuk M. S. , Turov A. V. , Ishchenko V. V. , Khilya V. P. 
Published: August 2005

AbstractFor Abstract see ChemInform Abstract in Full Text.
Synthesis and Herbicidal Activity of 2‐Cyano‐3‐(2‐fluoro‐5‐pyridyl)methylaminoacrylates.
Authors: Liu Yuxiu , Zhao Qiqi , Wang Qingmin , Li Heng , Huang Runqiu , Li Yonghong 
Published: August 2005

AbstractFor Abstract see ChemInform Abstract in Full Text.
Synthesis of 2‐R‐4,5,7‐Trimethyl‐1‐vinyl‐4,5,6,7‐tetrahydropyrrolo[3,2‐c]pyridines
Authors: Borisova T. N. , Bonifas Nsabimana , Voskresenskii L. G. , Chernyshev A. I. , Varlamov A. V. , Krapivko A. P. 
Published: August 2005

AbstractFor Abstract see ChemInform Abstract in Full Text.
Ring Fission of Chiral Cyclic Acetals Plus Intramolecular [4 + 2] Cycloaddition: A Sequential Access to Medium‐Size Lactones. Application to the Synthesis of Carbasugars.
Authors: Lemiegre Loic , Stevens Richard L. , Combret Jean‐Claude , Maddaluno Jacques 
Published: August 2005

AbstractFor Abstract see ChemInform Abstract in Full Text.
Synthesis of Multisubstituted 1,3‐Butadienes Using the Ruthenium‐Catalyzed Double Addition of Trimethylsilyldiazomethane to Alkynylboronates.
Authors: Morita Ryotaro , Shirakawa Eiji , Tsuchimoto Teruhisa , Kawakami Yusuke 
Published: August 2005

AbstractFor Abstract see ChemInform Abstract in Full Text.
Trivalent Atom Contribution on Solid—Solid Transformation of Ga13 Polycation Intercalated Clay into Sodalite Investigated by X‐Ray Absorption Spectroscopy.
Authors: Lee Sung‐Reol , Park Man , Han Yang‐Su , Hwang Sung‐Ho , Choy Jin‐Ho 
Published: August 2005

AbstractFor Abstract see ChemInform Abstract in Full Text.
Catalytic Properties and the Role of Copper in Bovine and Lentil Seedling Copper/Quinone‐Containing Amine Oxidases: Controversial Opinions
Authors: Agostinelli Enzo , Belli Francesca , Dalla Vedova Laura , Longu Silvia , Mura Anna , Floris Giovanni 
Published: August 2005

AbstractFor Abstract see ChemInform Abstract in Full Text.
A Chiral Copper Complex Forms Supramolecular Homochiral Helices viaO–H···Cl–Cu Interactions
Authors: Pradeep Chullikkattil P. , Zacharias Panthapally S. , Das Samar K. 
Published: August 2005

AbstractAn enantiopure ligand H2L [Schiff base prepared from (S)‐(+)‐2‐phenylglycinol and 2‐hydroxy‐5‐nitrobenzaldehyde] reacts with CuCl2·2H2O to yield a chiral copper complex [Cu(HL)Cl] (1) that forms right‐handed supramolecular helices via O–H···Cl–Cu hydrogen bonds. (© Wiley‐VCH Verlag GmbH & Co. KGaA, 69451 Weinheim, Germany, 2005)
Conformational Analysis of Chiral Ferrocene–Peptides
Authors: Heinze Katja , Beckmann Manuela 
Published: August 2005

AbstractFerrocene‐containing dipeptides Ac‐Fca‐AA‐OMe (AA = L‐Val, L‐Ile) with the artificial amino acid 1'‐aminoferrocene‐1‐carboxylic acid (Fca) and chiral α‐amino acid building blocks display hydrogen‐bonded structures that result in organised helical ferrocene units in solution, as evidenced by spectroscopic and theoretical investigations. (© Wiley‐VCH Verlag GmbH & Co. KGaA, 69451 Weinheim, Germany, 2005)
4f‐ansa‐Metallocenes—Dinuclear Complexes where the ansa‐Dicyclopentadienyl Ligands Simultaneously Act in a Chelating and Bridging Mode — Crystal Structure of (LY)2(μ‐L) [L = 2,6‐Pyridinediylbis(methylcyclopentadienyl)]
Authors: Paolucci G. , Vignola M. , Formenti S. , Massa W. 
Published: August 2005

AbstractThe reaction between [LNYX]2 [X = Cl, OTf; LN = 2,6‐pyridinediylbis(methylcyclopentadienyl] and L'Na2 [L' = LN = 2,6‐pyridinediylbis(methylcyclopentadienyl; LSi = dimethylsilanediylbis(cylopentadienyl); LO = 2,5‐furanediylbis(methylcyclopentadienyl)] in a 2:1 molar ratio affords dinuclear complexes of formula (LY)2(μ‐L'), in which the ansa‐bis(cyclopentadienyl) ligands simultaneously act both in a chelating and bridging mode. The X‐ray crystal structure of (LNY)2(μ‐LN), determined at 193 K shows an arrangement close to trigonal planar of the centroids Cg of the three Cp ligands around the Y atoms. The reactivity of the (LNLn)2(μ‐L') species containing different bridging ansa‐bis(cyclopentadienyl) groups with an additional free donor atom was tested to verify the possibility of coordination of a third lanthanide ion. The rearrangement reactions that occur, finally leading to the formation of the only [LNLnX]2 species, are likely to depend on the presence of the further coordinating atom in the ligand bridging the two metal ions. (© Wiley‐VCH Verlag GmbH & Co. KGaA, 69451 Weinheim, Germany, 2005)
A Tetraphosphane Imine Ligand Which Enforces Square‐Pyramidal Coordination
Authors: Zimmermann Christopher , Heinemann Frank W. , Grohmann Andreas 
Published: August 2005

AbstractThe tetrapodal pentadentate NP4 ligand 2,6‐C5H3N[CMe(CH2PPh2)2]2, which is readily prepared from the reaction of the corresponding tetrabromide with KPPh2, forms mononuclear complexes with nickel(II) and cobalt(II). In the case of nickel(II), the coordination mode adopted by the ligand is sensitive to the nature of the counterion: Use of NiCl2 gives a chloro complex as one of the products, which, as determined by X‐ray crystallography, has a central ion coordinated by three phosphane and one chloro substituent in a distorted square planar fashion; by contrast, the reaction with Ni(BF4)2 gives a complex of approximate square‐pyramidal geometry as the only product, in which all five atoms of the NP4 set are coordinated to the nickel ion, despite the steric bulk of the eight phenyl substituents. The same type of complex is obtained with Co(BF4)2 and Co(ClO4)2. Attempts to increase the coordination number of either complex beyond 5 have been unsuccessful. In particular, the cobalt(II) complex (17 valence electrons) is practically inert to reagents such as O2, NO, NO+, I2, Cl2 or H2. Full spectroscopic details for the complexes, as well as X‐ray structure analyses, are reported. (© Wiley‐VCH Verlag GmbH & Co. KGaA, 69451 Weinheim, Germany, 2005)
Unprecedented Coordination Mode Variation of Group 13 Metal–Alkyl Compounds Derived from Methyl Thiosalicylate
Authors: Lewiński Janusz , Bury Wojciech , Kopeć Tomasz , Tratkiewicz Ewa , Justyniak Iwona , Lipkowski Janusz 
Published: August 2005

AbstractThe X‐ray structure analysis of the alkylaluminum and‐indium compounds derived from methyl thiosalicylate,Me2Al(SC6H4‐2‐CO2Me) and [Me2In(μ‐SC6H4‐2‐CO2Me)]2, revealed that the intermolecular S···C(π) interaction between the Al–S thiolate units and the ester π‐surface can effectively compete with the hypercoordinate sulfur–metal dative bond. The former compound exists as the noncovalently bonded dimer involving the thiolate sulfur atom and the electrophilic carbon atom of the ester functionality, whereas the indium complex is a five‐coordinate dimer with the In2(μ‐S)2 central core. (© Wiley‐VCH Verlag GmbH & Co. KGaA, 69451 Weinheim, Germany, 2005)
Desymmetrizing Hydroformylation of Diallylcarbinols with the Aid of a Planar‐Chiral, Catalyst‐Directing Group
Authors: Breit Bernhard , Breuninger Daniel 
Published: August 2005

AbstractThe desymmetrizing hydroformylation of diallylcarbinols has been achieved by employing a planar‐chiral, substrate‐bound catalyst‐directing group — the ortho‐(diphenylphosphanyl)ferrocenylcarbonyl group (o‐DPPF). The method allows the simultaneous construction of two stereogenic centers in a 1,3‐relative position with high levels of stereocontrol. The diastereoselectivity was investigated as a function of substrate structure. Determination of the relative and absolute configuration of the product aldehydes (chemical derivatization and X‐ray crystallographic studies), as well as the conditions for removal and recovery of the catalyst‐directing o‐DPPF group, are described. Furthermore, a model is suggested that rationalizes the experimentally observed stereochemical result based on the minimization of syn‐pentane interactions. (© Wiley‐VCH Verlag GmbH & Co. KGaA, 69451 Weinheim, Germany, 2005)
Efficient Preparation of 4‐Iodofuran‐2(5H)‐ones by Iodolactonisation of 2,3‐Allenoates with I2
Authors: Fu Chunling , Ma Shengming 
Published: August 2005

Abstract4‐Iodofuran‐2(5H)‐ones were prepared, in moderate to high yields, by the facile iodolactonisation of ethyl 2,3‐allenoates with I2 in aqueous MeCN by the direct participation of the carbonyl oxygen atom in the regioselective electrophilic addition of the allene moiety. (© Wiley‐VCH Verlag GmbH & Co. KGaA, 69451 Weinheim, Germany, 2005)