bluuebunny/crossref_metadata_2025_split huggingface dataset:
Naringin Ameliorates IL-6 Mediated mitochondrial dysfunction and skeletal muscle degeneratio via AMPK/Nrf-2 pathway
Authors: Gao Shang , Wang Tianhao , Zhang Lu , Chen Shang , Jia Shu , Meng Chunyang , Wang Zheng , Zhang Zifang 
Published: January 2024

Abstract
Ethnopharmacological relevance: Paraspinal muscle degeneration often arises as a hazardous consequence of intervertebral disc degeneration (IVDD). This degeneration correlates with oxidative stress and mitochondrial dysfunction. This study investigated the therapeutic potential of naringin in managing paraspinal muscle degeneration associated with disc degeneration. Materials and methods: C2C12 cells were stimulated with IL-6 to establish an in vitro model of skeletal muscle degeneration for assessing the protective impact of naringin on skeletal muscle. The most effective concentration of naringin in C2C12 cells was identified through a CCK8 assay. The antioxidant prowess of naringin was evaluated via biochemical methods and Elisa. The influences of naringin and IL-6 on apoptosis, mitochondrial function, and associated signaling pathways were examined using cytometry, ROS detection, western blot, and transmission electron microscopy. Results: Our findings demonstrated a significant reduction in discogenic paraspinal degeneration with naringin therapy. Naringin glycosides notably enhanced the expression of key proteins involved in both muscle anabolism and catabolism, including MAFbx, MuRF1, MyoD, and MyoG.Moreover, naringin contributed to maintaining redox homeostasis by augmenting antioxidant activity and preventing excessive ROS peroxide accumulation. To impede paraspinal muscle degeneration, naringin upregulated MyoD and MyoG expression while downregulating MAFbx and MuRF1 through the activation of AMPK/Nrf-2 signaling pathway. Conclusion: These findings underscore naringin's robust therapeutic potential in enhancing mitochondrial activity, regulating oxidative stress, and halting paraspinal muscle degeneration.
Distortion is All You Need: From Image Denoising to Quality Assessment
Authors: Gui Zihan , Liu Jinwei , Yuan Chenghao , Yang Guangyi , He Wei 
Published: January 2024

Abstract
The necessity of a substantial dataset for training image quality assessment (IQA) models complicates their learning process, hindering generalizability. Under the differential mean opinion score (DMOS) evaluation standard, we propose an IQA model employing convolutional neural networks (CNNs) for feature extraction, particularly focusing on the intricate relationship between an image's complete response and its distortion information. Our model employs U-Net to extract distortion details, followed by CNN for feature extraction and attention detection on both distorted and undistorted information. This process yields local quality scores and attention weights, contributing to the overall image quality score through weighted summation. By prioritizing the extraction of image distortion information, our model reduces interference from redundant data, thus simplifying the training complexity. To further streamline training, we introduce the concept of \emph{priori distortion scale} (PDS) as an estimation parameter for U-Net iteration steps, eliminating the need for additional parameters. Evaluation on five datasets, including synthetic and real distortions, demonstrates the proposed model's superior performance compared to state-of-the-art IQA algorithms across various metrics. The comprehensive experimental results validate the efficacy of our approach.
Defining Agroecosystems and Suitability Analysis in the Tana Beles Sub Basin, Ethiopia
Authors: Weldegerima Tesfay Mekonnen 
Published: January 2024

Abstract

This study focuses on the imperative role of farming systems research in addressing agricultural challenges amid climate change. The primary aim is to assess agroecosystems and their suitability for farming practices within the Tana Beles Sub Basin (TBSB) in Ethiopia. Climate characterization involves utilizing observed rainfall and temperature data from the National Meteorology Agency (NMA) and gridded data from the WorldClim2 database for agro-climate zone delineation. Soil information is derived from the Harmonized World Soil Database version 1 (HWSD1), while agroecological data is collected from the regional Agriculture and Rural Development Bureau. Various analytical techniques, including agroclimate zoning, soil classification, farming classifications, and agro-ecosystem analysis, are employed. The TBSB is categorized into seven agroecosystems, with Moist Midlands (AES2) dominating the region, covering approximately 50% of the area. Altitudinal variation in AES2 ranges from 1500 m to over 2800 m, and key soils include Euteric Vertisol, Euteric Fulvisol, and Hapelic Luvisol. The topography spans flat plains to hilly mountains with slopes ranging from 0% to over 45%. AES2 supports diverse crops like Teff, Maize, Wheat, Barley, Rice, Chatt, and coffee, with the potential for irrigation schemes along the rivers. Suitability analysis reveals that AES2 is highly suitable for agriculture, AES4 and AES5 are moderately suitable, AES1, AES3, and AES6 are marginally suitable, and AES7 is unsuitable. This comprehensive assessment provides valuable insights into the diverse agroecological conditions within the TBSB, facilitating informed decision-making for sustainable agricultural development in the face of climate change.
Treatment of Small Cell Lung Cancer patients with brain metastases shows promise with the combination therapy of Cardonilumab and Anlotinib
Authors: Yi Hai-Zhen , Chen Jin-Jing , Lv Wei , Lin Zhan 
Published: January 2024

Abstract
The aim of this research was to evaluate the efficiency and security of the pairing of cardonilumab and anlotinib in individuals diagnosed with small cell lung cancer (SCLC) and brain metastases (BMs). Methods A review was performed on individuals who were diagnosed with small cell lung cancer (SCLC) and had central nervous system (CNS) metastases confirmed via magnetic resonance imaging (MRI) of the brain.We assessed the treatment response of cardonilumab plus anlotinib using RECIST 1.1 and RANO-BM for evaluating solid tumors and neuro-oncology brain metastases, respectively.The patients' prognosis was determined using Kaplan-Meier analysis and Cox regression analysis. Results The study included 46 individuals diagnosed with brain metastases (BMs) at the beginning. According to RANO-BM criteria, the intracranial lesions showed an objective response rate (ORR) of 80.4%.Additionally, the median overall survival (OS) was observed to be 19.3 months (95% CI, 17.4–21.1 months).The analysis of multivariate Cox regression showed that having a PD1 level below 50% (HR = 4.83, P < 0.001) or having two or more metastatic organs (HR = 2.71, P = 0.036) were independent factors that positively predicted overall survival.Out of all the patients, 86.9% experienced adverse events associated with the treatment, while 17.4% reported severe TRAEs of grade3-4. Conclusions According to our results, the combination of cardonilumab and anlotinib appears to be a promising treatment option for SCLC patients with brain metastases.
Effect of maternal Mala flavor preference on gestational weight gain mediated by dietary patterns in Chongqing, China: an ambispective cohort study
Authors: Li Jing Hua , Wang Di Fei , Mao Yan Yan , Zhang Wu Xia , Zhu Qian Xi , Liu Jun , Du Jing , Zhou Wei Jin , Wang Fen , Li Min 
Published: January 2024

Abstract
Background
Taste preference drives food selection, acceptance, or rejection, and influences body mass index. This study aimed to analyze the correlation of dietary status, encompassing taste preference and dietary pattern, with gestational weight gain (GWG) among pregnant women.
Methods
We conducted an ambispective cohort study at the Kaizhou District Maternal and Child Health Hospital in Chongqing, China. In total, 495 pregnant women aged 20–45 years who conceived naturally were recruited from May 2021 to November 2022. They had single pregnancies, no history of chronic medical and surgical diseases, and no pregnancy complications. Data on food category intake and taste preference, including fatty, salty, spicy, and Mala flavors, were collected during the third trimester. Factor analysis was used to evaluate dietary pattern. Multiple linear regression and structural equation modeling were performed to explore the relationship between taste preference and dietary pattern as well as their effects on GWG.
Results
“Traditional Diets” (TD) are characterized by high intakes of cereals, vegetables, fruits, meats, and dairy. “Modern Diets” (MD) are characterized by high intakes of cereals, vegetables, beans, meats, poultries, and seafood. “Quality Protein Diets” (QPD) are characterized by high intakes of seafood, eggs, and dairy. Pregnant women with a preference for Mala flavor had higher TD, MD, and QPD scores. Women with a higher TD or MD score had a higher GWG. The Mala taste preference effect on GWG was partially (41.7%) mediated by TD and MD.
Conclusions
Preference for Mala as the typical flavor in Chongqing has a positive effect on GWG, partially mediated by TD and MD, both of which are loaded with high amounts of cereals with high-glycemic index. Pregnant women in local areas should appropriately modify their Mala taste preference based on their current weight to maintain a reasonable GWG.
Late Pliocene growth of the West Antarctic Ice Sheet to near-modern dimensions
Authors: Rahaman Waliur , Gutjahr Marcus , Prabhat Priyesh 
Published: January 2024

Abstract
Accurate prediction of West Antarctic Ice Sheet (WAIS) collapse and its impact on sea level in future warmer climate states remains uncertain1. Understanding the Pliocene-Pleistocene ice sheet behaviour provides an opportunity to evaluate the role of forcing factors for ice mass gain/loss, determine the tipping points of WAIS growth/collapse and its impact on future sea level rise. Here, we provide evidence for the transition from a dynamic2 and smaller-sized WAIS during the warm Pliocene to a relatively stable and expanded ice sheet closer to its modern configuration during the Pleistocene based on the longest sedimentary geochemical records from Amundsen Sea, in proximity to modern maximum ice loss3. This transition coincided with initiation of orbitally paced 40-ka glacial-interglacial (G-I) cycles and atmospheric pCO2 drop, thus suggests that major tipping points for the growth and stability of the WAIS lies within atmospheric-oceanic conditions encountered during the Pliocene-Pleistocene transition. Despite large G-I variations in global temperature (+4 to -10 °C) and pCO2 (~180 – 280 ppm)4, the observation of relatively stable Pleistocene WAIS is contrary to model observations5,6 and questions its contribution to late Pleistocene sea level change. These findings have significant implications for predicting future ice sheet behavior and its impact on sea level rise.
The Effect of Angular Orientation and Eccentricity on the Melting Characteristics of a Latent Heat Thermal Energy Storage System: A Numerical Investigation
Authors: Kumar Himanshu , Singh Gurjeet , Yadav Ankit , Arıcı M. 
Published: January 2024

Abstract
Phase change materials (PCMs) are employed for storing latent heat energy contents in small regions owing to their high energy storage capacity at nearly constant temperature. The structural adjustment is proposed to study the effect on the melting rate of PCM to tackle the low thermal conductivity issue. A two-dimensional numerical model was developed to study the overall performance related to charging behaviour by way of firstly, performance analysis of the concentric position of Latent heat storage in a twin tube thermal energy system (TTTES) and secondly eccentricity of the inside tube in the heat exchanger. Analysis has been conducted for cases involving inclination in the heat exchanger, including scenarios with both concentric and eccentric configurations. In total 35 modes for the angular positions of 0°, 15°, 30°, 45°, 60°, 75°, and 90° having an inner tube eccentricity of 10, 20, 30, and 40 mm were identified and simulated. The findings revealed that the 90° angle of inclination (vertical) outperformed in terms of melting in comparison to other configurations of concentric TTTES. The result could be documented in terms of melting time reduction by 75% for a 90° angle of inclination in contrast to its 0° counterpart. Alongside that, the inner tube with a 20 mm eccentricity value recorded the best melting performance in comparison to all other eccentricity values. The TTTES demonstrates its maximum energy storage capacity of 307.72 kJ/kg at an inclination angle of 75° and an eccentricity of 10 mm.
The Effects of Climate Change Atmospheric Tempreture, Rainfall Pattern and Land Use Malaria Incidence Rates: a Retrospective Trend Analysis Over a Ten-year Period 2010-2020 in Luapula and Southern Province of Zambia
Authors: Phiri Joshua Kanjanga , Likwa  
Published: January 2024

Abstract
This study examines the impact of climate change on malaria incidence in Zambia. It focuses on variations in prevalence influenced by climatic and environmental factors. The study adopts a retrospective comparative analytical approach, utilizing 157 case records from each province. It investigates temperature, seasonal variations, and land use activities. The findings reveal a fluctuating trend of rainfall from 2010 to 2020, with a significant association between malaria incidence and rainfall (p-value = 0.041). In 2019, Southern Province experienced the highest percentage of drought (64%), resulting in reduced malaria transmission due to unfavorable environmental conditions for mosquito larvae. Demographic data highlight an urban-rural divide, with Luapula Province exhibiting a higher number of malaria cases among children under five. These results emphasize the critical role of climate change and local factors in malaria transmission dynamics.
Safety and efficacy of oral Alpha lipoic acid in the management of Diabetic Neuropathy: A Systematic Review and Meta-analysis
Authors: Das Susmita , Viswanatha Gollapalle Lakshminarayanashastry , Kishore Anoop , Nandakumar Krishnadas 
Published: January 2024

Abstract
Objective:To evaluate the efficacy and safety of oral alpha lipoic acid for the management of diabetic neuropathy.
Methods: A detailed literature search was performed using databases like Pubmed, Embase, and Google Scholar. The search was mainly focused on randomised controlled trials (RCTs) for evaluating the safety and efficacy of alpha-lipoic acid in managing diabetic neuropathy. Based on inclusion and exclusion criteria Eight studies were selected. Data were extracted to examine the quality and characteristics of the studies. Primary outcomes were HbA1c, neuropathy impairment score (NIS), neuropathy impairment score-low limb (NIS-LL), motor nerve conduction velocity (MNCV), neuropathy symptoms and change (NSC), total severity score (TSS), neurological disability score (NDS), and vibration perception thresholds (VPT). The secondary outcome was safety parameters.
Results: Eight randomized controlled trials met the inclusion criteria were selected and the efficacy and safety of Alpha lipoic acid in treating diabetic neuropathy were critically analyzed in comparison to the placebo group. The results of this systematic review and meta-analysis showed: Alpha lipoic acid has reduced HbA1c levels (Inverse variance (IV): -1.01 (-1.14 to -0.88) at 95% CI, p < 0.00001, I2 = 96%). ALA administration significantly decreased the Neuropathy Impairment Score (Inverse variance (IV): -1.18 (-1.35 to -1.02) at 95% CI, p<0.00001, I2=16%), ALA administration significantly decreased NIS-LL (Inverse variance (IV): -0.83 (-0.94 to -0.71) at 95% CI, p < 0.00001, I2 = 0%), ALA didn’t show significant improvement in MNCV Score (Inverse variance (IV): 0.07 (-0.67 to 0.81) at 95% CI, P = 0.85, I2 = 0%), ALA found to be beneficial in improving both NSC Number and NSC Severity score (Inverse variance (IV): -0.18 (-0.36 to -0.01) at 95% CI, P = 0.04, I2 = 0%) and (Inverse variance (IV): -0.64 (-0.82 to -0.47) at 95%CI, P < 0.00001, I2 = 89% ) respectively, ALA found to improve TSS (Inverse variance (IV): -0.45 (-0.61 to -0.28) at 95% CI, P < 0.00001, I2 = 98%), ALA shows significant improvement in NDS (Inverse variance (IV): -0.72 (-1.03 to -0.40) at 95% CI, p < 0.00001, I2 = 98%), ALA shows significant improvement in VPT (Inverse variance (IV): -0.36 (-0.52 to -0.20) at 95% CI, P < 0.0001, I2 = 96%) when compared with Placebo/control group.
Conclusion: The findings indicate that oral treatment with 600–1800 mg of alpha-lipoic acid may improve a few symptoms resulting from diabetic neuropathy and is a safe option when given at a low dose. At higher doses, it has shown adverse effects.
Inflation, Price Hike, and Service Quality: A Comprehensive Analysis of Customer Perception in the Realm of Sustainable Entrepreneurship
Authors: Cooper Mason , Bennett Noah , Hayes Isabella 
Published: January 2024

Abstract
This qualitative research explores the intricate dynamics of customer perceptions within the realm of sustainable entrepreneurship, specifically examining the influences of inflation, price hikes, and service quality. Through a thorough thematic analysis of semi-structured interviews, this study seeks to unravel the complex interplay between these economic factors and customer perspectives, providing valuable insights for businesses navigating the challenges of economic uncertainty. The findings underscore the significance of adopting a holistic approach when addressing economic challenges. Transparent communication emerges as a cornerstone, with businesses that prioritize open and honest engagement better positioned to retain customer loyalty in the face of inflation and price hikes. Trust-building efforts, anchored in reliability and transparency, are revealed as critical components of successful business strategies. Service quality emerges as a key differentiator, acting as a resilient factor that not only contributes to customer satisfaction but also mitigates the negative impact of economic fluctuations. The study emphasizes the strategic imperative for businesses to invest in customer experience, particularly during periods of economic challenges. Furthermore, sustainable entrepreneurship practices are identified as a positive influence on customer perceptions. Businesses committed to environmental and social responsibility are perceived as more trustworthy and resilient, contributing to an enhanced brand image. While offering practical implications for businesses seeking to navigate dynamic market environments, this study acknowledges its limitations and suggests avenues for future research. The complex interplay between economic factors and customer perceptions provides a foundation for continued exploration, positioning this research as a valuable contribution to the fields of business strategy and sustainable entrepreneurship.
Seasonal changes in the fatty acid profile of Kyrgyz khainak milk
Authors: Elemanova Rimma , Dzhunushalieva Tamara , Yurova Elena , Musulmanova Mukarama 
Published: January 2024

Khainak milk is a traditional source of nutrition for people living in the highlands of Kyrgyzstan. It is consumed both in its natural form and in the form of butter, cheese, and cottage cheese. We aimed to determine the composition of fatty acids in khainak milk, as well as its seasonal changes, since such data is lacking in literature.
Fatty acids were determined by gas chromatography qualitatively and quantitatively in the milk from five lactating khainaks farm-bred in the Issyk-Kul region. The milk samples were collected and analyzed in the spring, summer, autumn, and winter seasons over three years (2019, 2020, and 2021).
Kyrgyz khainak milk fat was mostly represented by saturated fatty acids, with a maximum content of 73.10 ± 2.19 g/100 g in winter. C14:0, C16:0, and C18:0 dominated in their composition, exceeding 5 g/100 g, with C16:0 (palmitic acid) reaching almost 35 g/100 g in winter. The flora of mountain pastures favorably contributed to monounsaturated fatty acids in khainak milk, especially oleic acid, whose content reached 26.85 ± 0.81 g/100 g in spring and then gradually declined to 18.90 ± 0.56 g/100 g, following changes in vegetation. Polyunsaturated fatty acids were found in small quantities varying from 3.25 ± 0.09 g/100 g in winter to 4.28 ± 0.12 g/100 g in summer.
The seasonal changes in the fatty acid profile of Kyrgyz khainak milk are most likely due to differences in the animals’ diet. Our data can be used to optimize the process parameters for the production of full-fat products from khainak milk (cheese, butter, sour cream, etc.).
Targeting Cervical Cancer Stem Cells by Phytochemicals
Authors: Tripathi Tanya , Yadav Joni , Janjua Divya , Chaudhary Apoorva , Joshi Udit , Senrung Anna , Chhokar Arun , Aggarwal Nikita , Bharti Alok Chandra 
Published: January 2024

:
Cervical cancer (CaCx) poses a significant global health challenge, ranking as
the fourth most common cancer among women worldwide. Despite the emergence of advanced
treatment strategies, recurrence remains a bottleneck in favorable treatment outcomes
and contributes to poor prognosis. The chemo- or radio-therapy resistance coupled
with frequent relapse of more aggressive tumors are some key components that contribute
to CaCx-related mortality. The onset of therapy resistance and relapse are attributed to a
small subset of, slow-proliferating Cancer Stem Cells (CSC). These CSCs possess the
properties of tumorigenesis, self-renewal, and multi-lineage differentiation potential. Because
of slow cycling, these cells maintain themselves in a semi-quiescent stage and protect
themselves from different anti-proliferative anti-cancer drugs. Keeping in view recent
advances in their phenotypic and functional characterization, the feasibility of targeting
CSC and associated stem cell signaling bears a strong translational value. The presence of
CSC has been reported in CaCx (CCSC) which remains a forefront area of research.
However, we have yet to identify clinically useful leads that can target CCSC. There is
compelling evidence that phytochemicals, because of their advantages over synthetic anticancer
drugs, could emerge as potential therapeutic leads to target these CCSCs. The present
article examined the potential of phytochemicals with reported anti-CSC properties
and evaluated their future in preclinical and clinical applications against CaCx.
Recent Progress in the Application of Exosome Analysis in Ovarian
Cancer Management
Authors: Keyvani Vahideh , Ghale-Noie Zari Naderi , Mollazadeh Samaneh , Mahmoudian Reihaneh Alsadat , Ghorbani Elnaz , Naderi Hamid , Khazaei Majid , Hassanian Seyed Mahdi , Ferns Gordon A. , Avan Amir , Anvari Kazem 
Published: January 2024

Abstract:
Exosomes are very small (nano-sized) vesicles participating in tumor development by
involvement in intercellular communication mediated by transferring biocomponents. Exosomes
appear to play vital roles in various cancer development, such as ovarian cancer, a common malignancy
in women. Several hallmarks of ovarian cancer are reported to be affected by the exosome--
mediated cellular cross-talk, including modulating peritoneal dissemination and chemoresistance.
Since the expression of some biomolecules, such as miRNAs and mRNA, is changed in ovarian
cancer, these exo-biomolecules can be applied as prognostic, diagnostic, and therapeutic biomarkers.
Also, the selective loading of specific chemotherapeutic agents into exosomes highlights these
biocarries as potential delivery devices. Exosomes could be artificially provided and engineered to
better target the site of interest in ovarian cancer. In the present review, we summarize the notable
achievement of exosome application in ovarian cancer management to gain applicable transitional
insight against this cancer.