bluuebunny/crossref_metadata_2025_split huggingface dataset:
The effect of interprofessional education on the work environment of health professionals: a scoping review
Authors: Medina-Córdoba Mariana , Cadavid Sara , Espinosa-Aranzales Angela-Fernanda , Aguía-Rojas Karen , Bermúdez-Hernández Pablo Andrés , Quiroga-Torres Daniel-Alejandro , Rodríguez-Dueñas William R. 
Published: December 2023

AbstractTo explore the existing literature on the effect of Interprofessional Education (IPE) on the work environment of health professionals. The research question was systematized according to the PCC (Population, Concept, and Context) format. A scoping review was performed. A search of multiple bibliographic databases identified 407 papers, of which 21 met the inclusion criteria. The populations of the 21 studies reviewed were composed of professionals in the fields of medicine, nursing, psychology, occupational therapy, physiotherapy, and social work, among others. The study contexts were both academic and nonacademic hospitals, mental health institutions, and community settings, and the topics examined were organizational climate, organizational culture, organizational attachment and job satisfaction. The findings from the reviewed studies showed positive effects of IPE interventions on organizational climate and culture, but the results on job satisfaction and organizational attachment were mixed (i.e., positive and no effects following IPE interventions). Research on IPE is worth more attention as IPE could be an effective alternative for the fulfillment of the Quadruple Aim and achieving the third of the United Nations Sustainable Development Goals, aimed at improving health and well-being. It seems critical for IPE to be positioned as a trend in global health, aiming at boosting human health resources as one of its building blocks and calling the attention of health decision-makers.
Regulating antimicrobial resistance: market intermediaries, poultry and the audit lock-in
Authors: Hinchliffe Steve , Bard Alison , Chan Kin Wing , Adam Katie , Bruce Ann , Reyher Kristen , Buller Henry 
Published: December 2023

AbstractAntimicrobial resistance (AMR) has become one of the defining challenges of the twenty-first century. Food production and farming are a key if troubling component of that challenge. Livestock production accounts for well over half of annual global consumption of antimicrobials, though the contribution of the sector to drug resistance is less clear. As a result, there is an injunction to act in advance of incontrovertible evidence for change. In this paper we engage with the role of market actors in the precautionary regulation of farming practices and AMR threats. The paper takes the UK poultry sector as exemplary of an audit-led process that has, in recent years, achieved impressive reductions in antimicrobial use. Using qualitative interview data with farmers and veterinarians we chart the changing practices that have accompanied this reduction in treatments. We use this analysis to raise some cautions around audit-led systems of regulation. Audits can lock farms and animals into particular versions of farming and animal health; they can elevate harmful compensatory practices (including disinfectant uses); and they can reproduce an actuarial approach to an issue that does not fit the conventions of risk management. The paper presents the considerable successes that have been achieved over a short period of time in a livestock sector, while generating notes of caution concerning the audit-led management of livestock-related AMR threats.
Examining current bias and future projection consistency of globally downscaled climate projections commonly used in climate impact studies
Authors: Berio Fortini Lucas , Kaiser Lauren R. , Frazier Abby G. , Giambelluca Thomas W. 
Published: December 2023

AbstractThe associated uncertainties of future climate projections are one of the biggest obstacles to overcome in studies exploring the potential regional impacts of future climate shifts. In remote and climatically complex regions, the limited number of available downscaled projections may not provide an accurate representation of the underlying uncertainty in future climate or the possible range of potential scenarios. Consequently, global downscaled projections are now some of the most widely used climate datasets in the world. However, they are rarely examined for representativeness of local climate or the plausibility of their projected changes. Here we explore the utility of two such global datasets (CHELSA and WorldClim2) in providing plausible future climate scenarios for regional climate change impact studies. Our analysis was based on three steps: (1) standardizing a baseline period to compare available global downscaled projections with regional observation-based datasets and regional downscaled datasets; (2) bias correcting projections using a single observation-based baseline; and (3) having controlled differences in baselines between datasets, exploring the patterns and magnitude of projected climate shifts from these datasets to determine their plausibility as future climate scenarios, using Hawaiʻi as an example region. Focusing on mean annual temperature and precipitation, we show projected climate shifts from these commonly used global datasets not only may vary significantly from one another but may also fall well outside the range of future scenarios derived from regional downscaling efforts. As species distribution models are commonly created from these datasets, we further illustrate how a substantial portion of variability in future species distribution shifts can arise from the choice of global dataset used. Hence, projected shifts between baseline and future scenarios from these global downscaled projections warrant careful evaluation before use in climate impact studies, something rarely done in the existing literature.
Otolith biochronology for the long-term reconstruction of growth and stock dynamics of fish
Authors: Smoliński Szymon , Gutkowska Julita 
Published: December 2023

AbstractLong-term biological time series are essential to evaluate previous responses of organisms to alterations in the environment. Biochronological methods based on archival fish otoliths allow setting such time series, but their predictive potential as proxies of past environmental conditions is still underexploited. In this study, we reconstructed growth variation in European sprat (Sprattus sprattus) in the Baltic Sea from 1956 to 2020 based on measurements of the archived otoliths. We used otolith annual increment widths as a proxy of fish somatic growth. We showed significant negative relationships between sprat growth and sprat spawning stock biomass (SSB) associated with strong intraspecific competition for limited food resources. We also identified a link between sprat growth and water salinity—indicator of the ecosystem's hydrological situation. For the first time, we estimated the SSB prior to the period of available historical data based on the otolith-derived information on the past growth variation. This estimation was based on the strong relationships between SSB and fish growth, complemented with temperature and salinity variables as predictors (R2 = 0.62). A model trained on at least 40 years of data from the more recent past allows us to robustly back-estimate SSB. This study provides new multidecadal data, giving insights into environmental factors affecting the growth of Baltic sprat, and demonstrates the potential of otolith-based biochronology for the provisioning of independent indices of the historical fish stock size. The proposed methodological approach broadens the portfolio of possible applications of the biochronology time series to indicate past changes in the aquatic environment.
Graphical abstract
Measurements and linearized models for golf ball bounce on a green
Authors: Biber Stanisław W. , Jones Kristian M. , Champneys Alan R. , Green Riku , Szalai Robert 
Published: December 2023

AbstractA detailed set of experiments are described that capture over a 1000 different instances of the bounce of a golf ball on a green. Video analysis was used to capture ball’s velocity and spin just before and after each bounce for a wide variety of landing conditions. Data are presented from two different turfs; one artificial and one from a typical tee. Measurement errors and repeatability are analysed. The data are compared to predictions from models of rigid bounce with friction, including Penner’s modification to account for elasto-plasticity. Coefficients of restitution and friction, and Penner’s effective contact angle are fit from the data. A better fit to the data is found using a non-physical piecewise-affine landing to lift-off relationship, which distinguishes between cases that bounce in pure slip from those that undergo rolling. Nevertheless, even balls that undergo rolling are typically found to lift-off slipping, having undergone spin reversal. The findings suggest that further effort needs to be spent on finding simple physics-based models of golf ball bounce on a green.
Kaemtakols A–D, highly oxidized pimarane diterpenoids with potent anti-inflammatory activity from Kaempferia takensis
Authors: Jongsomjainuk Orawan , Boonsombat Jutatip , Thongnest Sanit , Prawat Hunsa , Batsomboon Paratchata , Charoensutthivarakul Sitthivut , Ruchisansakun Saroj , Chainok Kittipong , Sirirak Jitnapa , Mahidol Chulabhorn , Ruchirawat Somsak 
Published: December 2023

AbstractFour highly oxidized pimarane diterpenoids were isolated from Kaempferia takensis rhizomes. Kaemtakols A–C possess a tetracyclic ring with either a fused tetrahydropyran or tetrahydrofuran motif. Kaemtakol D has an unusual rearranged A/B ring spiro-bridged pimarane framework with a C-10 spirocyclic junction and an adjacent 1-methyltricyclo[3.2.1.02,7]octene ring. Structural characterization was achieved using spectroscopic analysis, DP4 + and ECD calculations, as well as X-ray crystallography, and their putative biosynthetic pathways have been proposed. Kaemtakol B showed significant potency in inhibiting nitric oxide production with an IC50 value of 0.69 μM. Molecular docking provided some perspectives on the action of kaemtakol B on iNOS protein.
Graphical Abstract
Natural product rhynchophylline prevents stress-induced hair graying by preserving melanocyte stem cells via the β2 adrenergic pathway suppression
Authors: Li Xinxin , Shi Runlu , Yan Lingchen , Chu Weiwei , Sun Ruishuang , Zheng Binkai , Wang Shuai , Tan Hui , Wang Xusheng , Gao Ying 
Published: December 2023

AbstractNorepinephrine (NA), a stress hormone, can accelerate hair graying by binding to β2 adrenergic receptors (β2AR) on melanocyte stem cells (McSCs). From this, NA-β2AR axis could be a potential target for preventing the stress effect. However, identifying selective blockers for β2AR has been a key challenge. Therefore, in this study, advanced computer-aided drug design (CADD) techniques were harnessed to screen natural molecules, leading to the discovery of rhynchophylline as a promising compound. Rhynchophylline exhibited strong and stable binding within the active site of β2AR, as verified by molecular docking and dynamic simulation assays. When administered to cells, rhynchophylline effectively inhibited NA-β2AR signaling. This intervention resulted in a significant reduction of hair graying in a stress-induced mouse model, from 28.5% to 8.2%. To gain a deeper understanding of the underlying mechanisms, transcriptome sequencing was employed, which revealed that NA might disrupt melanogenesis by affecting intracellular calcium balance and promoting cell apoptosis. Importantly, rhynchophylline acted as a potent inhibitor of these downstream pathways. In conclusion, the study demonstrated that rhynchophylline has the potential to mitigate the negative impact of NA on melanogenesis by targeting β2AR, thus offering a promising solution for preventing stress-induced hair graying.
Graphical Abstract
A subgeometric convergence formula for finite-level M/G/1-type Markov chains: via a block-decomposition-friendly solution to the Poisson equation of the deviation matrix
Authors: Masuyama Hiroyuki , Katsumata Yosuke , Kimura Tatsuaki 
Published: December 2023

AbstractThe purpose of this study is to present a subgeometric convergence formula for the stationary distribution of the finite-level M/G/1-type Markov chain when taking its infinite-level limit, where the upper boundary level goes to infinity. This study is carried out using the fundamental deviation matrix, which is a block-decomposition-friendly solution to the Poisson equation of the deviation matrix. The fundamental deviation matrix provides a difference formula for the respective stationary distributions of the finite-level chain and the corresponding infinite-level chain. The difference formula plays a crucial role in the derivation of the main result of this paper, and the main result is used, for example, to derive an asymptotic formula for the loss probability in the MAP/GI/1/N queue.
If Long-Term Suppression is not Possible, how do we Minimize Mortality for Infectious Disease Outbreaks?
Authors: Handel Andreas , Miller Joel C. , Ge Yang , Fung Isaac Chun-Hai 
Published: December 2023

Abstract

Objective:
For any emerging pathogen, the preferred approach is to drive it to extinction with non-pharmaceutical interventions (NPI) or suppress its spread until effective drugs or vaccines are available. However, this might not always be possible. If containment is infeasible, the best people can hope for is pathogen transmission until population level immunity is achieved, with as little morbidity and mortality as possible.

Methods:
A simple computational model was used to explore how people should choose NPI in a non-containment scenario to minimize mortality if mortality risk differs by age.

Results:
Results show that strong NPI might be worse overall if they cannot be sustained compared to weaker NPI of the same duration. It was also shown that targeting NPI at different age groups can lead to similar reductions in the total number of infected, but can have strong differences regarding the reduction in mortality.

Conclusions:
Strong NPI that can be sustained until drugs or vaccines become available are always preferred for preventing infection and mortality. However, if people encounter a worst-case scenario where interventions cannot be sustained, allowing some infections to occur in lower-risk groups might lead to an overall greater reduction in mortality than trying to protect everyone equally.
Thomas Blanky (1804–1848/51?)
Authors: Schuster Frank M. 
Published: December 2023

Abstract
Much has been written about the so-called Franklin expedition (1845–), but not about the master mariners, who joined as “Greenland pilots,” as experienced whaling masters on Royal Navy expeditions were usually called in the 19th century. Having been on Royal Navy expeditions to the Arctic before, Thomas Blanky, the ice master of HMS Terror, was mentioned here and there in contemporary sources. But who he was and how and why he joined the expedition are still widely unanswered questions, to be dealt with for the first time here.
PARADOXES OF EGALITARIANISM: PRACTICE, MORAL ANALYSIS, AND POLICY PRESCRIPTIONS
Authors: Paul Jeffrey 
Published: December 2023

AbstractThis essay seeks to answer the question of how the behavior of wealthy advocates of some version of socialism can be reconciled with their advocacy of those ideas. The answer is that the conception of egalitarianism under which they choose to live is one that redistributes income, not wealth, while the egalitarianism that they advocate for others is that in which all wealth is the property of one person who decides how much will be distributed to others.
MAKING INEQUALITY VISIBLE WITHOUT MAKING IT WORSE
Authors: Chambers Clare 
Published: December 2023

AbstractEgalitarian commitments have often been thought compatible with practices that are later identified as inegalitarian. Thus, a fundamental task of egalitarianism is to make inequality visible. Making inequality visible requires including marginalized people, questioning what equality requires, and naming inequality. At the same time, egalitarianism is a movement for change: egalitarians want to make things more equal. When egalitarians seek change at the institutional level, the two egalitarian tasks are complementary: making inequality visible is part of campaigning to make things better. However, at the level of social norms there is a dilemma because making inequality visible can make things worse. Making inequality visible can reinforce unequal norms and fail to address intersectionality. The case of gendered pronouns illustrates this dilemma.
BEYOND HAYEKIAN EQUALITY
Authors: Haeffele Stefanie , Storr Virgil Henry 
Published: December 2023

AbstractFriedrich A. Hayek argues that “equality of the general rules of law and conduct” is the only kind of equality compatible with liberty and, moreover, that attempting to pursue equality along any other dimension is likely to destroy liberty. For Hayek, then, as a social philosopher and political economist who was principally concerned with understanding and promoting liberal order, the question “What kind of equality?” has a straightforward answer. Equality before the law, perhaps equality of opportunity in a procedural sense, is the equality that we should pursue, not material equality and certainly not equality of outcomes. One wonders, though, whether Hayek dismisses too quickly the more substantive forms of equality and, more importantly, whether we can achieve the liberal society that Hayek envisions without concerning ourselves with more than just the presence or absence of equality of the general rules of law and conduct. This essay will explore, criticize, and expand upon the way that Hayek makes use of equality in his conception of a free society. Specifically, we argue that Hayek may need a more substantive conception of equality than he is willing to deploy in order to arrive at the liberal society he hopes to bring about.
THE DEMANDS OF EQUALITY
Authors: Sypnowich Christine 
Published: December 2023

AbstractEver since the publication of G. A. Cohen’s essay “If You’re an Egalitarian, How Come You’re So Rich?” the matter of personal responsibility for the amelioration of economic disadvantage has become a question for egalitarian political philosophers to wrestle with both theoretically and personally. This essay examines “the demands of equality” in light of an egalitarian philosophy that focuses on human flourishing. I consider Cohen’s call for personal commitments to the egalitarian project to show both the power and problems of his approach and propose an alternative view, where individuals’ concern for living well involves an engagement with the demands of equality, but also some respite from its strictures.
Hope, Pessimism, and the Shape of a Just Climate Future
Authors: Lenzi Dominic 
Published: December 2023

AbstractThe urgency of climate change has never been greater, nor the moral case for responding to it more compelling. This review essay critically compares Darrel Moellendorf's Mobilizing Hope and Catriona McKinnon's Climate Change and Political Theory. Moellendorf's book defends the moral importance of poverty alleviation through sustainable economic growth and argues for a mass climate movement based on the promise of a more prosperous future. By contrast, McKinnon provides a political vocabulary to articulate the many faces of climate injustice, and to critically examine proposed policy solutions—notably including the indefinite pursuit of economic growth. While both find reasons to be hopeful, their wide-ranging accounts reflect different visions of what a just and sustainable future might look like. They reflect different understandings of sustainable development and the significance of environmental values; the scope of permissible climate activism; and the ethics of geoengineering. Building upon them, I argue in favor of a more pluralistic vision of a just climate future, one that is capable of speaking to the range of moral interests bearing upon the climate and biodiversity crises, and that supports sustainable development that is inclusive of diverse human-nature relationships.
Fine mapping and discovery of candidate genes for rind trait in watermelon
Authors: Wang Zhi Qiang , Du Huiying , Li Cheng 
Published: December 2023

AbstractFine mapping and discovery of watermelon rind trait candidate genes are of great significance for modern watermelon breeding and development. In this study, we used the high-resolution genetic mapping and genome-wide genetic variation detection technology, combined with genome survey and sequencing technology, to locate and discover the candidate genes for rind traits of star watermelon varieties ‘Su XuanBai’ and ‘SHLX21’. Firstly, we identified a total of eight quantitative trait loci (QTLs) related to watermelon rind traits on chromosome 6. Secondly, a total of 208,240 single nucleotide polymorphisms and 75,345 small Indels (insertions/deletions) were detected in the two parents by high-coverage re-sequencing, respectively. Based on the genetic variation of the two parents and combined with Gene Ontology (GO) and Kyoto Encyclopedia of Genes and Genomes (KEGG) analysis using the planta database, the QTL region was reduced to 0.02 Mb. Finally, we identified the six potential regulatory factors for watermelon rind traits using real-time quantitative PCR. In conclusion, our results revealed the fine localization of candidate genes for watermelon rind traits and the successful discovery of candidate genes for regulating watermelon rind traits, which is of importance for watermelon rind traits and breeding-improved watermelon varieties.
Analysis of agro-morphological variability and inter-trait relationships in Ghanaian groundnut (Arachis hypogaea L.) accessions
Authors: Adu Amoah Richard , Nelimor Charles , Gymafi Bright Adu , Boampong Richard , Osei Collins Yeboah , Yeboah Abraham , Sackey Victoria , Ansah Eric Osafo , Awuah Samuel , Mensah Abednego Opoku , Kwateng Yaw , Aboagye Lawrence Misa 
Published: December 2023

AbstractGermplasm characterization and evaluation are essential for the genetic improvement of crops. In this study, a collection of 204 groundnut accessions including 13 checks held by Plant Genetic Resources Research Institute, Ghana were evaluated under optimal conditions for 2 years. The objectives were to characterize the groundnut collection using 18 qualitative and 14 quantitative traits and to determine the relationships between the traits. Combined analysis of variance based on augmented design revealed significant differences (P < 0.05) among the accessions for majority of the traits. Results of principal component analysis showed that all the quantitative traits were relevant in discriminating the accessions. Primary seed colour was the most diverse qualitative trait based on Shannon diversity index (n = 0.77). Frequency distribution analysis showed predominance of decumbent growth habit and pale tan seeds. Cluster analysis using qualitative traits identified five major groups of accessions and three each based on quantitative traits and joint analysis of quantitative and qualitative traits. Number of main branches (NMB) and pod width (PW) appeared the most important traits with positive contribution to yield based on correlation and path coefficient analysis. Ten promising trait-specific accessions were identified for earliness along with desirable pod and seed traits. GH 9672 and GH 9665 were identified as promising for higher grain and fodder yield. Five accessions (GH 9833, GH 9829, GH 9830, GH 9835 and GH 9750) produced ~5–30% more grain yield than the best check. This study underscored ample phenotypic variation that would ultimately be exploited for genetic improvement of groundnut.