bluuebunny/crossref_metadata_2025_split huggingface dataset:
Thin Ice Lithospheres and High Heat Flows on Europa From Large Impact Structure Ring‐Graben
Authors: Singer K. N. , McKinnon W. B. , Schenk P. M. 
Published: December 2023

AbstractCraters are probes of planetary surface and interior properties. Here we measure depths, widths, and spacing of circumferential ring‐graben surrounding the two largest multiring impact structures on Europa, Tyre and Callanish. We estimate formation conditions including the ice shell structure. The radial extension necessary to form these graben is thought to be caused by asthenospheric drag of warmer, more ductile ice and/or water flowing toward the excavated center of the crater, under a brittle‐elastic lithospheric lid. Measurements of graben depths from stereo‐photoclinometric digital elevation models result in estimates of displacement, strain, and stress experienced by the ice shell. Graben widths are used to estimate the intersection depth of the bounding normal faults, a quantity related to the brittle‐ductile transition depth that approximates elastic shell thickness during crater collapse. Heat flows at the time of crater formation as well as ice lithosphere and total shell thickness are thus also constrained. Average widths and depths tend to decrease with increasing distance from the structure center, while inter‐graben spacing generally increases. Varied assumptions yield plausible total conductive ice shell thickness estimates between 4–8 and 2.5–5 km for Tyre and Callanish, respectively, and heat flows of ∼70–115 (±30) mW m−2 for realistic thermal conductivities, consistent with other geophysical estimates for Europa. Higher heat flows are consistent with thin (≲10 km), conductive ice shells and impact breaching, or penetration of the stagnant lid for a convecting ice shell. Callanish, geologically younger, formed in a time or region of greater heat flow than Tyre.
Estimating Geomagnetically Induced Currents in High‐Voltage Power Lines for the Territory of Kazakhstan
Authors: Andreyev A. B. , Mukasheva S. N. , Kapytin V. I. , Sokolova O. I. 
Published: December 2023

AbstractExtreme solar events, such as powerful solar flares are accompanied by the release of strong solar disturbances, such as coronal mass ejections (CMEs). The impact of CMEs on the Earth's magnetosphere causes geomagnetic storms, which trigger geomagnetic effects measurable in the ionosphere, upper atmosphere, and on and in the ground. During extreme cases, rapidly changing geomagnetic fields generate intense geomagnetically induced currents (GICs), which can cause dramatic effects on man‐made technological systems, including transmission lines and pipelines. In countries with large territories such as Kazakhstan, long power lines contribute to high values of induced currents during periods of extreme geoeffective solar events. It is of interest to estimate the values of GICs in an extensive network of power lines on the territory of Kazakhstan. However, there are no estimations of induced currents in power lines in Kazakhstan, and most estimation techniques are made difficult because of absence of field measurements of Earth conductivity. This study aims to model geoelectric fields on the surface of the Earth for Kazakhstan and to estimate the values of the GICs in 500 kV power lines. This study also compares between two methods for calculating induced voltages in power lines: one based on linear paths and the other based on curvilinear paths between substations of transmission power lines.
Analysis of gasoline-related pollutant exposures and risks in California between 1996 and 2014
Authors: Sultana Daniel , Hoover Sara 
Published: December 2023

Abstract
Background
Gasoline-powered vehicles and equipment are an important source of air pollution in California. Many gasoline-related pollutants pose significant health concerns. The California Air Resources Board strictly regulates the state’s gasoline formulation and vehicle emissions.

Objective
To investigate exposure trends for gasoline-related air pollutants between 1996 and 2014, capturing the period before and after the removal of methyl t-butyl ether (MTBE).

Methods
We identified gasoline-related chemicals with known or suspected health concerns and adequate ambient air monitoring data. Average exposures to the general public were estimated from 1996 to 2014 in five major air basins and statewide. We determined the fractions of exposures attributable to gasoline use and evaluated cancer and non-cancer risks for chemicals with available cancer potencies and health reference values.

Results
We found that average gasoline-attributable cancer risks for the general California population from the most highly emitted carcinogens (acetaldehyde, benzene, 1,3-butadiene, and formaldehyde) declined by over 80% between 1996 and 2014. This decline occurred despite roughly constant statewide gasoline sales, an increase in vehicle miles traveled, and an approximately 10% increase in vehicle registrations over this same period. Naphthalene, measured as a volatile organic compound (VOC), was the most abundant gasoline-related polycyclic aromatic hydrocarbon (PAH). From 1996 to 2014, gasoline-attributable cancer risks for naphthalene were estimated to drop approximately threefold in the South Coast Air Basin. Exposures to gasoline-related chemicals associated with non-cancer health effects, such as chronic respiratory toxicity or neurotoxicity, were generally below levels of concern. The exception was acrolein, with gasoline-related exposures in 2014 estimated to be high enough to pose risks for respiratory toxicity.

Impact statement
Our historical analysis demonstrated the success of California’s regulatory efforts to reduce gasoline-related air pollutant exposures and risks to the general public. New efforts are focused on addressing gasoline-related and other air pollution in heavily impacted communities affected by multiple environmental and social stressors.
ERK hyperactivation serves as a unified mechanism of escape in intrinsic and acquired CDK4/6 inhibitor resistance in acral lentiginous melanoma
Authors: Jagirdar Kasturee , Portuallo Marie E. , Wei Meihan , Wilhide Matthew , Bravo Narula Jeremy A. , Robertson Bailey M. , Alicea Gretchen M. , Aguh Crystal , Xiao Min , Godok Tetiana , Fingerman Dylan , Brown Gregory Schuyler , Herlyn Meenhard , Elad Vissy M. , Guo Xinyu , Toska Eneda , Zabransky Daniel J. , Wubbenhorst Bradley , Nathanson Katherine L. , Kwatra Shawn , Goyal Yogesh , Ji Hongkai , Liu Qin , Rebecca Vito W. 
Published: December 2023

AbstractPatients with metastatic acral lentiginous melanoma (ALM) suffer worse outcomes relative to patients with other forms of cutaneous melanoma (CM), and do not benefit as well to approved melanoma therapies. Identification of cyclin-dependent kinase 4 and 6 (CDK4/6) pathway gene alterations in >60% of ALMs has led to clinical trials of the CDK4/6 inhibitor (CDK4i/6i) palbociclib for ALM; however, median progression free survival with CDK4i/6i treatment was only 2.2 months, suggesting existence of resistance mechanisms. Therapy resistance in ALM remains poorly understood; here we report hyperactivation of MAPK signaling and elevated cyclin D1 expression serve as a mechanism of intrinsic early/adaptive CDK4i/6i resistance. ALM cells that have acquired CDK4i/6i resistance following chronic treatment exposure also exhibit hyperactivation of the MAPK pathway. MEK and/or ERK inhibition increases CDK4i/6i efficacy against therapy naïve and CDK4i/6i-resistant AM cells in xenograft and patient-derived xenograft (PDX) models and promotes a defective DNA repair, cell cycle arrested and apoptotic program. Notably, gene alterations poorly correlate with protein expression of cell cycle proteins in ALM or efficacy of CDK4i/6i, urging additional strategies when stratifying patients for CDK4i/6i trial inclusion. Concurrent targeting of the MAPK pathway and CDK4/6 represents a new approach for patients with metastatic ALM to improve outcomes.
Injury-specific factors in the cerebrospinal fluid regulate astrocyte plasticity in the human brain
Authors: Sirko Swetlana , Schichor Christian , Della Vecchia Patrizia , Metzger Fabian , Sonsalla Giovanna , Simon Tatiana , Bürkle Martina , Kalpazidou Sofia , Ninkovic Jovica , Masserdotti Giacomo , Sauniere Jean-Frederic , Iacobelli Valentina , Iacobelli Stefano , Delbridge Claire , Hauck Stefanie M. , Tonn Jörg-Christian , Götz Magdalena 
Published: December 2023

AbstractThe glial environment influences neurological disease progression, yet much of our knowledge still relies on preclinical animal studies, especially regarding astrocyte heterogeneity. In murine models of traumatic brain injury, beneficial functions of proliferating reactive astrocytes on disease outcome have been unraveled, but little is known regarding if and when they are present in human brain pathology. Here we examined a broad spectrum of pathologies with and without intracerebral hemorrhage and found a striking correlation between lesions involving blood–brain barrier rupture and astrocyte proliferation that was further corroborated in an assay probing for neural stem cell potential. Most importantly, proteomic analysis unraveled a crucial signaling pathway regulating this astrocyte plasticity with GALECTIN3 as a novel marker for proliferating astrocytes and the GALECTIN3-binding protein LGALS3BP as a functional hub mediating astrocyte proliferation and neurosphere formation. Taken together, this work identifies a therapeutically relevant astrocyte response and their molecular regulators in different pathologies affecting the human cerebral cortex.
Ambiguous genes due to aligners and their impact on RNA-seq data analysis
Authors: Szabelska-Beresewicz Alicja , Zyprych-Walczak Joanna , Siatkowski Idzi , Okoniewski Michał 
Published: December 2023

AbstractThe main scope of the study is ambiguous genes, i.e. genes whose expression is difficult to estimate from the data produced by next-generation sequencing technologies. We focused on the RNA sequencing (RNA-Seq) type of experiment performed on the Illumina platform. It is crucial to identify such genes and understand the cause of their difficulty, as these genes may be involved in some diseases. By giving misleading results, they could contribute to a misunderstanding of the cause of certain diseases, which could lead to inappropriate treatment. We thought that the ambiguous genes would be difficult to map because of their complex structure. So we looked at RNA-seq analysis using different mappers to find genes that would have different measurements from the aligners. We were able to identify such genes using a generalized linear model with two factors: mappers and groups introduced by the experiment. A large proportion of ambiguous genes are pseudogenes. High sequence similarity of pseudogenes to functional genes may indicate problems in alignment procedures. In addition, predictive analysis verified the performance of difficult genes in classification. The effectiveness of classifying samples into specific groups was compared, including the expression of difficult and not difficult genes as covariates. In almost all cases considered, ambiguous genes have less predictive power.
Linguistic characteristics in bipolar disorder versus borderline personality disorder
Authors: Muriel Noelia Santos , López Resa Patricia , Moraleda Sepúlveda Esther 
Published: December 2023

AbstractScientific evidence has documented throughout the research carried out in recent years, the neuropsychological, behavioral and adaptive difficulties presented by people with Bipolar Disorder and Borderline Personality Disorder at different stages of their development. However, little importance has been given to other factors such as communication, especially in the adult population. The objective of this research was to know the language characteristics presented by people from both groups and the differences in linguistic development. The sample consisted of 60 participants between the ages of 17 and 42:31 of them with a diagnosis of Borderline Personality Disorder and the remaining 29 with a diagnosis of Bipolar Disorder. The standardized evaluation instruments were: the Social Skills Scale and the Pragmatic Competence Questionnaire completed by three different informants (families, professionals and the own person). The results obtained show that both populations manifest linguistic difficulties in adulthood and that there are differences depending on the perception of the agent involved in the language assessment. These results are highly relevant since they provide up-to-date information about language level, support the need for language intervention in adulthood, and reflect a different communicative profile in Bipolar Disorder and Borderline Personality Disorder.
Elevation determines the productivity of large cardamom (Amomum subulatum Roxb.) cultivars in Sikkim Himalaya
Authors: Lepcha Patrush , Gaira Kailash S. , Pandey Aseesh , Chettri Santosh Kumar , Lepcha Jarina , Lepcha Jhony , Joshi Rajesh , Chettri Nakul 
Published: December 2023

AbstractLarge cardamom (Amomum subulatum Roxb.) is an economically important cash crop that provides a livelihood option for the rural communities in Sikkim Himalaya. However, its production has declined drastically over the past few decades due to climate change and other factors affecting the livelihood of marginal cardamom-dependent farmers in the region. Climate change causes a shift in elevational distributions of mountain species, and it is pivotal to understand its effect on yield and yield-related traits for economically important plant species like large cardamom. For this, we randomly studied 41 large cardamom cultivation sites in Sikkim (India) with elevations ranging between 975 and 2069 m asl and evaluated the yield-related traits (number of capsules per spike, capsule length, capsule width, fresh capsule weight, dry capsule weight, number of seeds per locule, fresh seed weight, and dry seed weight) in five cultivars (Dzongu Golsey, Sawney, Seremna, Ramsey, and Varlangey). We observed a significant variability (P < 0.05) for morphometric traits in each of the five cultivars cultivated in different elevations. The cultivation of low-elevation cultivars like Seremna and Dzongu Golsey (suitable in elevation < 975 m) has shifted upward to mid (975–1515 m) and high-elevation (> 1515 m), while cultivation of high-elevation Ramsey cultivar (suitable in elevation > 1515 m) has shifted downward (< 1515 m). The Dzongu Golsey, Sawney, and Seremna cultivated in mid-elevation (975–1515 m) performed better in terms of yield-related traits than the same cultivars cultivated in high-elevation (> 1515 m) and showed moderate to high negative correlation between elevation and yield-related traits, indicating the negative effect of elevation on their yield. Likewise, Ramsey and Varlangey cultivated in high elevation (> 1515 m) performed better than the one cultivated in mid-elevation (975–1515 m) and depicted moderate to high positive correlation between elevation and yield-related traits, suggesting a positive influence of elevation on their yield. Although there is an elevational shift in the cultivation of large cardamom cultivars, the elevation influences the performance of the large cardamom cultivars, and it also suggests cultivating the cultivars in their suitable elevation range for better productivity.
Integrating DNA methylation and gene expression data in a single gene network using the iNETgrate package
Authors: Sajedi Sogand , Ebrahimi Ghazal , Roudi Raheleh , Mehta Isha , Heshmat Amirreza , Samimi Hanie , Kazempour Shiva , Zainulabadeen Aamir , Docking Thomas Roderick , Arora Sukeshi Patel , Cigarroa Francisco , Seshadri Sudha , Karsan Aly , Zare Habil 
Published: December 2023

AbstractAnalyzing different omics data types independently is often too restrictive to allow for detection of subtle, but consistent, variations that are coherently supported based upon different assays. Integrating multi-omics data in one model can increase statistical power. However, designing such a model is challenging because different omics are measured at different levels. We developed the iNETgrate package (https://bioconductor.org/packages/iNETgrate/) that efficiently integrates transcriptome and DNA methylation data in a single gene network. Applying iNETgrate on five independent datasets improved prognostication compared to common clinical gold standards and a patient similarity network approach.
Despite misinformation, low trust, and conflict in Somalia, high demand for vaccines and a negative endorsement effect of non-state authorities
Authors: Aarslew Laurits F. , Haas Nicholas , Khadka Prabin B. 
Published: December 2023

AbstractExpanding vaccination coverage in conflict regions is crucial to the prevention of further mutations and outbreaks of COVID-19, as well as of future pandemics, worldwide. However, scholars’ suppositions that low levels of trust and control over the flow of misinformation in these regions may necessitate tailored solutions—in particular, that health advice come from trusted non-state authorities—remain largely untested. To better understand the levels and drivers of COVID-19 vaccine receptivity in conflict regions, we partnered with the United Nations and the Somali Ministry of Justice to field a three-wave panel survey ($$N_1$$

N
1

= 1672; $$N_2$$

N
2

= 880; $$N_3$$

N
3

= 908) and vaccine endorsement experiment in South Central Somalia. We observe high overall demand for vaccines (between 90 and 94%), particularly among those who have experienced violence and illness, who perceive high economic disruption due to the pandemic, and who report more favorable views of and exposure to the West and Western-affiliated organizations. The high overall demand is particularly striking given respondents’ low interpersonal trust and considerable exposure to vaccine disinformation. Contrary to scholars’ and policymakers’ expectations, we find that whereas endorsements from government health authorities increase vaccine receptivity, endorsements from non-state customary authorities and extremist militant group Al-Shabaab decrease support for vaccination (− 8 and − 16% points, respectively). Our findings caution against presupposing a need for different approaches to increasing vaccination coverage in conflict regions, and suggest that at least in the short-term, constraints on vaccine supply and access are more likely to bind than those on demand.
Geographical distribution-based differentiation of cultivated Angelica dahurica, exploring the relationship between the secretory tract and the quality
Authors: Wu Qinghua , Jiang Lan , Yan Yuhang , Yan Qi , Zhu Xinglong , Zhang Jiaxu , Huang Chengfeng , Zhou Tao , Ren Chaoxiang , Wen Feiyan , Pei Jin 
Published: December 2023

AbstractBased on geographical distribution, cultivated Chinese Angelica dahurica has been divided into Angelica dahurica cv. ‘Hangbaizhi’ (HBZ) and Angelica dahurica cv. ‘Qibaizhi’ (QBZ). Long-term geographical isolation has led to significant quality differences between them. The secretory structure in medicinal plants, as a place for accumulating effective constituents and information transmission to the environment, links the environment with the quality of medicinal materials. However, the secretory tract differences between HBZ and QBZ has not been revealed. This study aimed to explore the relationship between the secretory tract and the quality of two kinds of A. dahurica. Root samples were collected at seven development phases. High-Performance Liquid Chromatography (HPLC) and Desorption Electrospray Ionization Mass Spectrometry Imaging (DESI-MSI) were used for the content determination and spatial location of coumarins. Paraffin section was used to observe and localize the root secretory tract. Origin, CaseViewer, and HDI software were used for data analysis and image processing. The results showed that compared to QBZ, HBZ, with better quality, has a larger area of root secretory tracts. Hence, the root secretory tract can be included in the quality evaluation indicators of A. dahurica. Additionally, DESI-MSI technology was used for the first time to elucidate the temporal and spatial distribution of coumarin components in A. dahurica root tissues. This study provides a theoretical basis for the quality evaluation and breeding of improved varieties of A. dahurica and references the DESI-MSI technology used to analyze the metabolic differences of various compounds, including coumarin and volatile oil, in different tissue parts of A. dahurica.
Assessment of interobserver concordance in radiomic tools for lung nodule classification, with a focus on BRODERS and SILA
Authors: Al-Ghoula Faysal , Patel Khushbu , Falde Sam , Rajagopalan Srinivasan , Bartholmai Brian , Maldonado Fabien , Peikert Tobias 
Published: December 2023

AbstractWhile CT lung cancer screening reduces lung cancer-specific mortality, there are remaining challenges. Radiomic tools promiss to address these challenges, however, they are subject to interobserver variability if semi-automated segmentation techniques are used. Herein we report interobserver variability for two validated radiomic tools, BRODERS (Benign versus aggRessive nODule Evaluation using Radiomic Stratification) and CANARY (Computer-Aided Nodule Assessment and Risk Yield). We retrospectively analyzed the CT images of 95 malignant lung nodules of the adenocarcinoma spectrum using BRODERS and CANARY. Cases were identified at Mayo Clinic (n = 45) and Vanderbilt University Medical Center and Nashville/Veteran Administration Tennessee Valley Health Care System (n = 50). Three observers with different training levels (medical student, internal medicine resident and thoracic radiology fellow) each performed lung nodule segmentation. All methods were carried out in accordance with relevant guidelines and regulations. Interclass correlation coefficients (ICC) of 0.77, 0.98 and 0.97 for the average nodule volume, BRODERS cancer probability and Score Indicative of Lesion Aggression (SILA) which summarizes the distribution of the CANARY exemplars indicated good to excellent reliability, respectively. The dice similarity coefficient was 0.79 and 0.81 for the data sets from the two institutions. BRODERS and CANARY are robust radiomics tools with excellent interobserver variability. These tools are simple and reliable regardless the observer/operator’s level of training.
Imaging of vertical surface-breaking cracks in concrete members using ultrasonic shear wave tomography
Authors: Kuchipudi Sai Teja , Pudovikov Sergey , Wiggenhauser Herbert , Ghosh Debdutta , Rabe Ute 
Published: December 2023

AbstractSurface-breaking cracks in concrete pose a significant threat to the durability of built structures. They create pathways for an accelerated moisture intrusion, and the transport of environmental and chemical agents such as chloride ions, which in turn, exacerbate reinforced concrete deterioration. Estimating the extent of crack propagation beneath the surface helps in determining the safety, durability and reliability of a structure. This information can be used to devise appropriate repair methodologies. Developments in Dry Point Contact (DPC)-based ultrasonic arrays have enabled the detection and localization of defects in concrete through high-resolution imaging. This work proposes the use of Half-Skip travel modes in the time-domain pulse-echo data to be deployed for imaging vertical cracks in concrete. In contrast to the standard Synthetic Aperture Focusing Technique (SAFT), which is widely used for ultrasonic imaging of concrete, the Half-Skip Total Focusing Method (HSTFM) configuration uses the target-scattered signals after a reflection from the back wall. The technique has been evaluated on both simulated and experimentally measured ultrasonic data on specimens fabricated with notches and cracks of different depths. Crack sizes were estimated by measuring the length of thresholded reflection signatures obtained in the images. The presented solution using half-skip modes serves as a supplementary technique to standard SAFT, in order to estimate the depth of surface-breaking cracks in concrete.