bluuebunny/crossref_metadata_2025_split huggingface dataset:
WITHDRAWN: Analysis of Clinical and Demographic Characteristics among Turkish Patients with Neurofibromatosis Type 1, with a Focus on Dermatological Features
Authors: Ahmadi Vahid , Karimi Nazli , Evans Sibel Ersoy , Karaduman Ayşen 
Published: February 2024

Abstract
Background
Neurofibromatosis type 1 (NF1) is an autosomal dominant disorder characterized by distinct clinical features.
Aim
This study aims to address this gap by investigating the demographic and clinical features of NF1 in the Turkish population.
Methods
A retrospective review of the medical records of 128 patients diagnosed with Neurofibromatosis Type 1 (NF1) over a three-year period was conducted.The analysis focused on investigating the demographic and clinical characteristics of the patients, including key parameters such as vitamin D levels and also Body Mass Index (BMI).
Result
Nevus anemicus was present in 32.8% of NF1 patients, and a significant association was found between nevus anemicus and low vitamin D levels (p = 0.001). Although a higher frequency of neurofibromas was observed in patients with low serum vitamin D levels, but the difference was not statistically significant.
Conclusion
Our findings suggest an association between NF1 and lower vitamin D levels. Additionally, individuals with decreased vitamin D levels may demonstrate an increased susceptibility to the development of neurofibromas and a higher prevalence of nevus anemicus. To gain a better understanding of this relationship, we propose the necessity of a prospective study. Such a study would be instrumental in evaluating the correlation between nevus anemicus and vitamin D levels in both NF1 patients and a healthy control group.
Forecasting the Enrolment of Bank Term Deposits: A case study approach with Cross-Industry Standard Process for Data Mining (CRISP-DM) methodology.
Authors: Tunca Sezai 
Published: February 2024

Abstract
This case study employs the Cross-Industry Standard Process for Data Mining (CRISP-DM) methodology to forecast the enrollment of bank term deposits by analyzing a dataset obtained from Moro et al. (2014). The study aims to provide data-driven strategic recommendations to a bank's marketing department by understanding the factors influencing the likelihood of a customer subscribing to a term deposit. The dataset includes various demographic and financial variables, and the analysis employs logistic regression and support vector machine (SVM) models. The CRISP-DM methodology guides the project through stages such as business understanding, data preparation, modeling, and evaluation. The logistic regression model demonstrates high accuracy, and both models meet success criteria, providing valuable insights for enhancing marketing strategies. The study acknowledges limitations, such as the dataset's limited representation of the customer population and potential biases from oversampling, while recommending future research with different machine learning models and extensive datasets for more comprehensive results. The primary objective is to offer strategic guidance to the marketing department, focusing on significant variables and improving communication strategies based on critical findings from the analysis.
Is it bad apples or bad barrels? Undergraduate Medical Students Attitude towards Plagiarism; Transcultural Study
Authors: Abdelnasser Asmaa , Abouzeid Enjy , Mostafa Enas M A , Mahmoud Manal Ibrahim Hanafi , Wasfy Nourhan F. , Shehata Shaimaa A 
Published: February 2024

Abstract

Background
Plagiarism is a significant violation of academic integrity since it diminishes the value of original and honest academic work. Plagiarism is becoming increasingly common in medical colleges around the world, posing significant obstacles for educators, faculty, and policymakers in addressing such ethical dilemmas and limiting potential risks and liabilities as well.
Aim
to explore the attitude of medical students towards plagiarism and identify the underlying factors that may influence plagiarism using a mixed quantitative and qualitative transcultural approach.
Methods
This two-phase observational mixed-method study utilized a probability-stratified random sample technique to include medical students from two schools, in Egypt and Saudi Arabia. The attitude of the students was investigated using The Attitudes Towards Plagiarism (ATP) questionnaire, a validated online self-administered questionnaire. It was distributed electronically to 387 medical students from both schools. Additionally, two focus group sessions were conducted following an inductive approach and underwent thematic analysis.
Results
A total of 387 medical students completed the questionnaires, 182 participants from Egyptian Medical School and 205 from Saudi Medical School. A majority (73.9%) had not received previous plagiarism training. The category-wise distribution of the study participants in the two medical schools in all components of the ATP scale showed that a vast majority fell in the moderate category. The overall mean (SD) scores were for Egyptian and Saudi Medical Students’ positive attitude (35, 33), negative attitude (23, 22), and subjective norms (31, 30). The thematic analysis of the focus group discussions categorized the student responses under three themes: Understanding Plagiarism, Drivers of Plagiarism, and Proactive Preventive Measures for Plagiarism.
Conclusion
This study provides an insightful analysis of students' understanding of plagiarism, particularly in the context of academic writing. Key factors identified as contributing to plagiarism include language barriers, poor academic writing skills, the challenging nature of assignments, strict deadlines, and an assessment focus on scores. The study also notes the dual role of technology in this context and underscores the significant impact of cultural influences on students' perceptions of plagiarism.
Water quality indexes and water quality population perception in a rural area in Ecuador
Authors: Roldán-Reascos Gloria , Pérez-Lamela Concepción , de Blas Esther , Simal-Gandara Jesus 
Published: February 2024

Abstract

This studỳs aim was to evaluate the quality of water for human consumption in a rural area of Ecuador. For this purpose, two water quality indexes were used: the Water Quality Index (WQI) and the Simplified Water Quality Index (SWQI). Sampling campaigns were carried out during the years 2018 and 2019, and 18 parameters were analyzed, including pH, conductivity, dissolved oxygen, temperature, color, phosphates, nitrites, nitrates, biochemical oxygen demand, chemical oxygen demand, total suspended solids, turbidity, methylene blue active substances, fats and oils, total coliforms, ammonia, nitrogen, and fecal coliforms. The WQI and the SWQI yielded values between 79.80 and 81.31 (2018) and between 76.99 and 79.89 (2019), respectively. Multivariate statistical methods were applied to implement water management recommendations. The perception of water quality was assessed through a survey of the population. This study contributes to recommending a proposal for the adoption of a WQI in Ecuador. The obtained results indicate that the water in the studied area needs the conventional treatment to achieve adequate quality for human consumption.
Increased ACSL6 Expression Predicts a Favorable Prognosis in Triple-negative Breast Cancer
Authors: Hua Hui , Pan Shuaikang , Diao Haizhou , Cao Yueyue , Qian Xiaojun , Zhang Jinguo 
Published: February 2024

Background:
Long-chain acyl-coenzyme A synthases (ACSLs) are responsible
for the catalysis of fatty acids into their corresponding fatty acyl-CoAs. The dysregulation
of ACSLs has been increasingly recognized in cancer patients. However, the function
of ACSL6 in triple-negative breast cancer (TNBC) is still completely unknown.

Methods:
In this study, immunohistochemistry was applied to detect ACSL6 protein expression
using a TNBC tissue microarray. Additionally, the mRNA levels of ACSL6 in
human normal tissues and pancancer tissues were analyzed using Genotype Tissue Expression
(GTEx) datasets and The Cancer Genome Atlas (TCGA) database. The correlations
between the levels of ACSL6 expression and clinical characteristics were analyzed.
The survival analysis of ACSL6 in TNBC was carried out using the Kaplan‒Meier
Plotter online tool. Associations of ACSL6 with immune infiltration analyses were
conducted using the ESTIMATE, CIBERSORT, and TISIDB databases. The relationship
between ACSL6 and sensitivity to drugs was analyzed from Genomics of Drug Sensitivity
in Cancer (GDSC).

Results:
The results indicated a significant increase in ACSL6 expression in TNBC tissues
compared to adjacent normal tissues. However, high ACSL6 expression was significantly
associated with favorable survival outcomes in TNBC patients. Enrichment analysis
revealed that coexpressed genes of ACSL6 were significantly enriched in various immunity
processes. ACSL6 was positively correlated with the infiltration of memory
CD4 T cells, while a negative correlation was found between ACSL6 and M2
macrophages and resting dendritic cells. Further analysis revealed that high levels of ACSL6
correlated with increased survival outcomes in cancer patients who received immunotherapy.

Conclusion:
Altogether, the current findings highlight the potential value of ACSL6 as
a diagnostic and prognostic marker in the treatment of TNBC.
Efficacy and Mechanisms of Silybum Marianum, Silymarin, and Silibinin
on Rheumatoid Arthritis and Osteoarthritis Symptoms: A Systematic
Review
Authors: Habibi Ghahfarrokhi Shahrzad , Heidari-Soureshjani Saeid , Sherwin Catherine MT , Azadegan-Dehkordi Zahra 
Published: February 2024

Background:
Rheumatoid arthritis (RA) and osteoarthritis (OA) are the most common
forms of skeletal disease worldwide.

Objective:
The current systematic review investigated the mechanisms of Silybum marianum, silymarin,
and silibinin on RA and OA symptoms.

Methods:
The PRISMA 2020 statement was used for reporting Items in this systematic review.
The result was a list of five databases, including Web of Science, Cochrane Library, Embase,
PubMed, and Scopus. After determining the inclusion and exclusion criteria, of 437 records identified,
21 studies were eligible. The data were extracted from the studies and imported into an Excel
form, and finally, the effects, outcomes, and associated mechanisms were surveyed.

Results:
Silybum marianum and its main constituents revealed immunomodulatory, anti-inflammatory,
antioxidant, and anti-apoptotic properties in humans and laboratory animals. Moreover, they
protect the joints against the cartilage matrix's hypocellularity and fibrillation, reduce synovitis,
and inhibit degeneration of aggrecan and collagen-II in human chondrocytes. They also, through
reducing inflammatory cytokines, show an analgesic effect. Although silymarin and silibinin have
low absorption, their bioavailability can be increased with nanoparticles.

Conclusion:
In experimental studies, Silybum marianum, silymarin, and silibinin revealed promising
effects on RA and OA symptoms. However, more clinical studies are needed in this field to obtain
reliable results and clinical administration of these compounds.
A Case of Intractable Hypophosphatemia in a Patient with Guillain-Barré
Syndrome and Encephalitis after SARS-CoV-2 Infection
Authors: Zheng Yawen , Hou Yuanyuan , Qi Mingzhu , Zhang Yongxiang , Han Chao , Sun Hui , Li Jiang 
Published: February 2024

Background:
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection
attacks the respiratory and nervous systems. Among patients with SARS-CoV-2 infection,
cases with simultaneous central and peripheral nervous system damage are rare, and those with
intractable hypophosphatemia and hypokalemia complicating the former have not been reported
yet.

Case Presentation:
A 59-year-old woman presented to the emergency department with incoherent
speech evolving for 3 days. She had tested positive for the SARS-CoV-2 RT-PCR assay 8
days earlier. Her physical examination showed progressive limb weakness with diminished tendon
reflexes and normal sensory examination. Cranial MRI revealed multiple abnormal signals
in the brain. Cerebrospinal fluid (CSF) analysis and electromyography revealed acute motor
axonal neuropathy (AMAN), further diagnosed as encephalitis combined with Guillain‑Barré
syndrome (GBS). The patient received glucocorticoid therapy, intravenous immune globulin
(IVIG), and rehabilitation therapy. The patient experienced an intractable hypophosphatemia
and hypokalemia during the treatment period, which was not effectively corrected several times.
The symptoms improved after 1 month of treatment.

Conclusion:
Early diagnosis is important for the management of Guillain-Barré syndrome associated
with SARS-CoV-2 infection. Moreover, in order to prevent life-threatening long-term
persistent electrolyte disturbances in non-seriously ill patients, clinicians should pay particular
attention to their electrolyte status.
Tinospora Cordifolia, A Rasayana Herb, as a Potential Source of Infectious Disease Therapeutics
Authors: Paliwal Paras , Ul- Islam Muneeb , Sharma Shweta , Sharma Anuradha 
Published: February 2024

Introduction:
Ayurveda is a well-established traditional medicinal system in India
which focuses on the treatment of chronic illnesses and the promotion of overall wellness. A
significant upsurge has been observed in the research and development of traditional medicine in
the 21st century. Tinospora cordifolia is a valuable Rasayana herb of Ayurveda with various medicinal
properties like anticancer, antiobesity, hepatoprotective, antiulcer, antimicrobial, and
immunomodulatory.

Aim:
The current study aims to review the antimicrobial potential of T. cordifolia based on a
number of available scientific evidence.

Methodology:
Literature was retrieved from PubMed, Google Scholar, and other databases with
a combination of different keywords, including antimicrobial, antifungal, antiviral, antiparasitic,
antiviral, immunomodulatory, antioxidant, antiinflammatory with T. cordifolia, and the obtained
reports were analyzed.

Results:
Various studies indicate the antimicrobial potential of this herb against different viral,
bacterial, fungal, and parasitic pathogens. The majority of the available evidence include the preliminary
screening of the antimicrobial activities. To highlight the societal acceptance of T. cordifolia
in this context, some value-added products based on this herb have also been discussed
briefly.

Conclusion:
T. cordifolia has antimicrobial potential, which could be explored for the development
of natural products-based therapeutics for infectious disease treatment. Cytotoxic, antioxidative,
anti-inflammatory and immunomodulatory properties of T. cordifolia contribute to minimizing
microbial colonization and strengthening the immune system against emerging infections.
Herbal medicines are associated with some limitations, such as low effectiveness, seasonal
variations of phytochemicals etc. More detailed studies are required to understand the underlying
mechanism and the responsible phytochemicals, which will enhance the translational value of T.
cordifolia-based phytotherapeutics.
Clinical Informatics Team Members’ Perspectives on Health Information Technology Safety After Experiential Learning and Safety Process Development: Qualitative Descriptive Study
Authors: Recsky Chantelle , Rush Kathy L , MacPhee Maura , Stowe Megan , Blackburn Lorraine , Muniak Allison , Currie Leanne M 
Published: February 2024

Background
Although intended to support improvement, the rapid adoption and evolution of technologies in health care can also bring about unintended consequences related to safety. In this project, an embedded researcher with expertise in patient safety and clinical education worked with a clinical informatics team to examine safety and harm related to health information technologies (HITs) in primary and community care settings. The clinical informatics team participated in learning activities around relevant topics (eg, human factors, high reliability organizations, and sociotechnical systems) and cocreated a process to address safety events related to technology (ie, safety huddles and sociotechnical analysis of safety events).

Objective
This study aimed to explore clinical informaticians’ experiences of incorporating safety practices into their work.

Methods
We used a qualitative descriptive design and conducted web-based focus groups with clinical informaticians. Thematic analysis was used to analyze the data.

Results
A total of 10 informants participated. Barriers to addressing safety and harm in their context included limited prior knowledge of HIT safety, previous assumptions and perspectives, competing priorities and organizational barriers, difficulty with the reporting system and processes, and a limited number of reports for learning. Enablers to promoting safety and mitigating harm included participating in learning sessions, gaining experience analyzing reported events, participating in safety huddles, and role modeling and leadership from the embedded researcher. Individual outcomes included increased ownership and interest in HIT safety, the development of a sociotechnical systems perspective, thinking differently about safety, and increased consideration for user perspectives. Team outcomes included enhanced communication within the team, using safety events to inform future work and strategic planning, and an overall promotion of a culture of safety.

Conclusions
As HITs are integrated into care delivery, it is important for clinical informaticians to recognize the risks related to safety. Experiential learning activities, including reviewing safety event reports and participating in safety huddles, were identified as particularly impactful. An HIT safety learning initiative is a feasible approach for clinical informaticians to become more knowledgeable and engaged in HIT safety issues in their work.
Low-Fidelity Prototype of a Sensor-Dependent Interaction Platform: Formative Evaluation With Informal Caregivers of Older Adults With Cognitive Impairment
Authors: Sharma Nikita , Grotenhuijs Karen , Gemert-Pijnen J E W C van , Oinas-Kukkonen Harri , Braakman-Jansen L M A 
Published: February 2024

Background
Unobtrusive sensing technologies developed for monitoring deviant behaviors in older adult care require integration with an interaction platform to facilitate the flow of information between older adults and their caregivers. However, the continuous monitoring capabilities generate a considerable amount of data that must be interpreted, filtered, and personalized before being communicated to the informal caregivers based on their specific care needs and requirements.

Objective
For the effective implementation of unobtrusive sensing solutions (USSs) in the care of older adults with cognitive impairment, we aimed to explore the expectations and preconditions regarding the implementation of USSs from the perspective of informal caregivers. Subsequently, we designed and evaluated a low-fidelity prototype of an interaction platform for its conceptual workflow and usability, incorporating persuasive system design features based on the needs and requirements of informal caregivers.

Methods
Overall, 6 informal caregivers of older adults with cognitive impairment living alone participated in this qualitative interview study. We explored the expectation and preconditions regarding implementation through open-ended questions and conducted a formative evaluation (usability study with a think-aloud approach) to evaluate the conceptual workflow and used persuasive system design features in the interaction platform. Overall, a combination of inductive and thematic analyses was used to analyze the interviews.

Results
The results of this study present both positive and negative outcome expectations regarding the implementation of USSs, highlighting benefits such as objective decision-making and peace of mind and concerns about information overload and the potential substitution of human contact. Strategic information communication agreements between informal and formal caregivers were deemed crucial for the successful implementation of USSs in care. Overall, informal caregivers had a positive experience with the low-fidelity prototype of the interaction platform, particularly valuing the personalization feature.

Conclusions
In conclusion, to achieve successful implementation, a holistic design approach is necessary, and equal consideration should be given to the personalization-privacy paradox to balance users’ needs and privacy.
Perancangan Sistem Informasi Absensi Menggunakan Smartcard Berbasis Internet of Things Pada CV. Anugerah Mandiri
Authors: Muzakki Muhammad Zain Iqbal , Nuryasin Ilyas , Sumadi Fauzi Dwi Setiawan 
Published: February 2024

Absensi merupakan sebuah kegiatan pengambilan data guna mengetahui jumlah kehadiran karyawan atau pegawai pada suatu instansi pemerintah/perusahaan. Absensi karyawan sangat dibutuhkan untuk mengetahui tingkat disiplin yang tinggi dan menilai sistem kerja dari setiap karyawan. Tujuan dari penelitian ini adalah mengembangkan sebuah sistem informasi absensi karyawan pada CV. Anugerah Mandiri dan sebuah reader berbasis IoT yang akan membaca data dari smartcard. Metode yang digunakan pada penelitian ini adalah metode prototype. Metode prototype digunakan karena metode ini mudah apabila ada perubahan dan dengan menggunakan prototype client lebih mudah memahami sistem yang akan dibuat. Setelah dilakukan pengujian menggunakan pengujian blackbox, didapatkan hasil bahwa sistem informasi absensi karyawan dapat berjalan sesuai yang diharapkan dan semua fitur dapat bekerja dengan baik. Begitu juga dengan reader IoT yang dapat berjalan dengan baik.
Perkembangan Pasa Ateh (Pasar Atas) Bukittinggi Hingga Menjadi Plaza Tahun 2017-2023
Authors: Ramadhan Mutiara Yulia , Asri Zul 
Published: February 2024

In the research talk about the development of Pasa Ateh (Upper Market) Bukittinggi after it experienced a fire and became a plaza (2017-2023). Of this study focusses about discusses the physical development of the Pasa Ateh (Upper Market) Bukittinggi building after the fire until it became a plaza and explains the economic and social impact of traders caused by the revitalization of the market building after the fire. The aim of this research is to see the development of Pasa Ateh (Upper Market) Bukittinggi after the fire until it became a plaza and see the social and economic impact caused by the revitalization of the market after the fire. This research includes qualitative historical research, using the historical method which includes 4 stages, namely: heuristic method by searching for historical data related to Pasa Ateh (Upper Market), source criticism in the form of selecting data that has been taken, interpretation in the form of interpreting historical data, and Historiography is the rewriting of History. From the first discussion, Pasa Ateh (Upper Market) Bukittinggi experienced a fire in 2017. Second, the development of Pasa Ateh (Upper Market) in terms of physical buildings. Third, the social and economic impacts resulting from the revitalization of buildings.
Keywords: History, Development, Pasa Ateh (Upper Market), Social and Economic