bluuebunny/crossref_metadata_2025_split huggingface dataset:
Suprapatellar tibial fracture nailing is associated with lower rate for acute compartment syndrome and the need for fasciotomy compared with the infrapatellar approach
Authors: Honkonen Essi E. , Repo Jussi P. , Lehtokangas Heidi , Luoma Emma , Uimonen Mikko , Nurmi Sami , Ylitalo Antti , Riuttanen Antti , Kivelä Tiia , Mattila Ville M. , Suomalainen Piia 
Published: January 2024

Abstract
Background
Intramedullary tibial nailing (IMN) is the gold standard for stabilizing tibial shaft fractures. IMN can be performed through an infra- or suprapatellar approach.

Purpose
The aim of this study is to compare the rate of fasciotomies for acute compartment syndrome between infra- and suprapatellar approaches.

Methods
A total of 614 consecutive patients who were treated with IMN for tibial fracture between October 2007 and February 2020 were included in the study. The approach used for IMN was determined by the operating surgeon. Infrapatellar IMN was performed with the knee in deep flexion position, with or without calcaneal traction. Suprapatellar IMN was performed in straight or semiflexed position. The diagnosis of compartment syndrome was based on clinical analysis, but for some patients, a continuous compartment pressure measurement was used. The primary outcome was the rate of peri- and postoperative compartment syndrome treated with fasciotomies.

Results
The study sample included 513 patients treated with infrapatellar IMN and 101 patients treated with suprapatellar IMN technique. The mean age of the patients was 44.7 years (infrapatellar technique) and 48.4 years (suprapatellar technique). High energy trauma was seen in 138 (27%) patients treated with infrapatellar technique and in 39 (39%) patients treated with suprapatellar technique. In the suprapatellar group (n = 101), there were no cases of peri- or postoperative compartment syndrome treated with fasciotomies. In the infrapatellar group (n = 513), the need for fasciotomies was stated in 67 patients, 31 patients (6.0%) perioperatively and in 36 patients (7.0%) postoperatively. The rate of fasciotomies (0/101 versus 67/513 cases) differed significantly (p < 0.001). There were no significant differences in the fracture morphology or patient demographics between the study groups.

Conclusions
The suprapatellar technique is recommended over the infrapatellar approach in the treatment of tibial shaft fractures. The rate of peri- and postoperative compartment syndrome and the need for fasciotomies was significantly lower with the suprapatellar technique. The major cause of increased rate of peri- or postoperative acute compartment syndrome with infrapatellar IMN technique is presumably associated with the positioning of the patient during the operation.

Level of evidence
3.
Mesoporous silica nanotechnology: promising advances in augmenting cancer theranostics
Authors: Dutta Gupta Yashaswi , Mackeyev Yuri , Krishnan Sunil , Bhandary Suman 
Published: January 2024

AbstractOwing to unique facets, such as large surface area, tunable synthesis parameters, and ease of functionalization, mesoporous silica nanoparticles (MSNs) have transpired as a worthwhile platform for cancer theranostics over the last decade. The full potential of MSNs in cancer theranostics, however, is yet to be realized. While MSNs can be employed for targeted drug delivery and imaging, their effectiveness can frequently be hindered by factors, such as biological barriers, complex tumor microenvironment, target non-specificity and ineffectiveness of individual functionalized moieties. The primary purpose of this review is to highlight technological advances such as tumor-specific, stimuli-responsive “smart” MSNs and multimodal MSN-based hybrid nanoplatforms that have the potential to overcome these limitations and improve MSN effectiveness in cancer theranostics. This article offers an extensive overview of MSN technology in cancer theranostics, outlining key directions for future research as well as the challenges that are involved in this aspect. We aim to underline the vitality of MSN technology and the relevance of current research and advancements in this field to potentially enhance clinical outcomes through the provision of more precise and focused theranostic approaches.
New information on paleopathologies in non-avian theropod dinosaurs: a case study on South American abelisaurids
Authors: Baiano Mattia A. , Cerda Ignacio A. , Bertozzo Filippo , Pol Diego 
Published: January 2024

AbstractStudies on pathological fossil bones have allowed improving the knowledge of physiology and ecology, and consequently the life history of extinct organisms. Among extinct vertebrates, non-avian dinosaurs have drawn attention in terms of pathological evidence, since a wide array of fossilized lesions and diseases were noticed in these ancient organisms. Here, we evaluate the pathological conditions observed in individuals of different brachyrostran (Theropoda, Abelisauridae) taxa, including Aucasaurus garridoi, Elemgasem nubilus, and Quilmesaurus curriei. For this, we use multiple methodological approaches such as histology and computed tomography, in addition to the macroscopic evaluation. The holotype of Aucasaurus shows several pathognomonic traits of a failure of the vertebral segmentation during development, causing the presence of two fused caudal vertebrae. The occurrence of this condition in Aucasaurus is the first case to be documented so far in non-tetanuran theropods. Regarding the holotype of Elemgasem, the histology of two fused vertebrae shows an intervertebral space between the centra, thus the fusion is limited to the distal rim of the articular surfaces. This pathology is here considered as spondyloarthropathy, the first evidence for a non-tetanuran theropod. The microstructural arrangement of the right tibia of Quilmesaurus shows a marked variation in a portion of the outer cortex, probably due to the presence of the radial fibrolamellar bone tissue. Although similar bone tissue is present in other extinct vertebrates and the cause of its formation is still debated, it could be a response to some kind of pathology. Among non-avian theropods, traumatic injuries are better represented than other maladies (e.g., infection, congenital or metabolic diseases, etc.). These pathologies are recovered mainly among large-sized theropods such as Abelisauridae, Allosauridae, Carcharodontosauridae, and Tyrannosauridae, and distributed principally among axial elements. Statistical tests on the distribution of injuries in these theropod clades show a strong association between taxa-pathologies, body regions-pathologies, and taxa-body regions, suggesting different life styles and behaviours may underlie the frequency of different injuries among theropod taxa.
Multivitamin consumption and childhood asthma: a cross-sectional study of the NHANES database
Authors: Zhang Li , Xu Yali , Li Xuemei , Yang Fan , Wang Chengxiu , Yu Chunmei 
Published: January 2024

Abstract
Background
Dietary intakes of vitamins are associated with asthma. However, previous studies mainly explored the association between a single vitamin intake and asthma, which did not take the multivitamins into consideration. Herein, this study aims to explore the overall effect of dietary multivitamins consumption on childhood asthma.

Methods
Data of children and adolescents (aged 2-17 years old) were extracted from the National Health and Nutrition Examination Survey (NHANES) database in 2015-2018 in this cross-sectional study. Weighted univariate logistic regression analysis was used to screen covariates. The association between multivitamins (including vitamin A, C, D, E, B1, B2, B6, B12, K, niacin, folic acid, and choline) and childhood asthma was explored using univariate and multivariate logistic regression analyses. The evaluation indexes were odds ratio (OR) and 95% confidence interval (CI). We further introduced the Bayesian kernel machine regression (BKMR) to assess the joint effect of the twelve vitamins on childhood asthma, the impact of an individual vitamin as part of a vitamin mixture, and the potential interactions among different vitamins.

Results
Among 4,715 eligible children and adolescents, 487 (10.3%) had asthma. After adjusting for covariates including race, family history of asthma, pregnant smoking, BMI Z-score, energy intake, breast feeding, and low birth weight, we found that for each 1-unit increase in vitamin K consumption, the odds of childhood asthma decreased 0.99 (P=0.028). The overall effect analysis reported a trend of negative relationship between the multivitamins and childhood asthma, especially at the 75th percentile and over. According to the BKMR models, when other vitamins are fixed at the median level, the odds of childhood asthma increased along with the elevated vitamin D (VD) and vitamin B2 (VB2), whereas along with the depressed vitamin C (VC). In addition, no potential interaction has been found between every two vitamins of multivitamins on childhood asthma.

Conclusion
Among children and adolescents who have high-risk of asthma, it may be beneficial to increase dietary consumption of multivitamins. Our findings recommended that children and adolescents should increase the intake of VC-rich foods, whereas control the dietary consumption of VD and VB2 in daily life.
Self-efficacy, mindfulness, and perceived social support as resources to maintain the mental health of students in Switzerland’s universities of applied sciences: a cross-sectional study
Authors: Guzman Villegas-Frei Myriam , Jubin Jonathan , Bucher Claudia Ortoleva , Bachmann Annie Oulevey 
Published: January 2024

Abstract
Background
Switzerland’s student population is at a particularly high risk of developing mental health disorders, creating a major challenge for Switzerland’s higher education establishments. Research to date has primarily sought to identify the risk factors affecting students’ mental health; however, their exposure to these factors is often unavoidable. Thus, the present study adopted a salutogenic approach focussing on the determinants of health. We examined the mental health resources available to students reported in the literature as being susceptible to helping them maintain good mental health despite their exposure to risk factors.

Methods
In February 2020, 2,415 first- and second-year bachelor’s degree students in applied sciences in French-speaking Switzerland completed an online questionnaire. The variables measured were self-evaluated mental health, perceived stress and three potential health resources: students’ feelings of self-efficacy, their capacity for mindfulness and their social support. The results were analysed using hierarchical linear regression models.

Results
When all the variables were included in the model without interaction effect, our results revealed that students’ self-evaluated mental health was negatively associated with perceived stress (β = -0.43, p < 0.001) and positively associated with the three potential health resources (self-efficacy: β = 0.26, p < 0.001; mindfulness: β = 0.10, p < 0.001; social support: β = 0.17, p < 0.001). An analysis of the interaction effects also revealed that a high level of self-efficacy was associated with perceived stress being less strongly linked to mental health (β = 0.29, p < 0.001).

Conclusions
These findings suggest that self-efficacy, mindfulness, and perceived social support are valuable resources for protecting students’ mental health. Thus, implementing interventions aimed at reinforcing them, could support students in applied sciences all along their academic pathway, in their classes and during their professional work experience placements.
Associations of latent patterns of parent‒child communication with communication quality and mental health outcomes among Chinese left-behind children
Authors: Xie Qian-Wen , Chen Roujia , Wang Kexin , Lu Jingjing , Wang Feng , Zhou Xudong 
Published: January 2024

Abstract
Background
Parent‒child communication in migrant families is essential to family bonds and the mental health of left-behind children (LBC). Little is known about the different patterns of communication between migrant parents and LBC and associated communication quality and mental health outcomes.

Methods
A sample of 2,183 Chinese children (mean age = 12.95 ± 1.29 years) from Anhui province, including LBC whose parents had both migrated (n = 1,025) and children whose parents had never migrated (never-LBC, n = 1,158), was analyzed. With the LBC sample, latent class analysis was applied to identify the patterns of parent‒child communication. Multinomial logistic regression analysis was conducted to assess the associations between the sociodemographic variables and class membership of LBC. Analysis of covariance and chi-square tests were used to compare communication quality and mental health outcome differences among the classes of LBC and between each of the classes and never-LBC.

Results
Five latent classes of communication formed through different media or channels between migrant parents and their LBC were identified. Higher household economic status (OR = 2.81, p < 0.05) was associated with adequate communication. LBC in Class 1, defined by frequent technologically-mediated and face-to-face communication, had a significantly higher quality of communication with their migrant parents (F = 8.92, p < 0.001) and better mental health than those in other latent classes; these children did not have significantly worse mental health outcomes compared to never -LBC.

Conclusions
Facilitating multichannel parent‒child communication is a practical way of reducing mental health inequities between LBC and their peers.
A new mathematical model for evaluating surface changes in the mid-abdominal sagittal plane after two-level pedicle reduction osteotomy in patients with ankylosing spondylitis
Authors: Yin Wen , Zheng Guohui , Zhang Wei , Zhai Yunlei , Li Haijiang , Sun Lele , Wang Kangkang , Jiang Jishi , Hua Zikai , Cui Xilong , Yu Haiyang 
Published: January 2024

AbstractBackgroundThe purpose of this study was to create a mathematical model to precalculate the acreage change in the abdominal median sagittal plane (ac-AMSP) of patients with ankylosing spondylitis (AS) for whom two-level pedicle subtraction osteotomy (PSO) was planned.MethodsA single-centre retrospective review of prospectively collected data was conducted among 11 adults with AS. Acreage of the abdominal median sagittal plane (a-AMSP) was performed. The distances and angles between the osteotomy apexes, anterosuperior edge of T12, xiphoid process, superior edge of the pubis, and anterosuperior corner of the sacrum were measured on preoperative thoracolumbar computed tomography. A mathematical model was created using basic trigonometric functions in accordance with the abdominal parameters. Planned osteotomized vertebra angles (POVAs) were substituted into the mathematical model, and the predictive ac-AMSP (P-AC) was obtained. A paired sample t test was performed to determine the differences between the P-AC and actual ac-AMSP (A-AC) and between the predictive acreage change rate (P-CR) and actual acreage change rate (A-CR).ResultsThe mean age and GK were 44.4 ± 8.99 years and 102.9° ± 19.17°, respectively. No significant difference exists between A-CR and P-CR via mathematical modeling (p > 0.05). No statistically significant difference existed between POVA and actual osteotomized vertebra angles (AOVA) (p > 0.05). A statistically significant difference was observed between preoperative and postoperative measurements of LL, SVA, and GK variables (p < 0.001).ConclusionsThe novel mathematical model was reliable in predicting the ac-AMSP in AS patients undergoing two-level PSO.
Shear bond strength of calcium silicate-based cements to glass ionomers
Authors: Ergül Ruken , Aksu Seçkin , Çalışkan Seçil , Tüloğlu Nuray 
Published: January 2024

Abstract
Background
A shear bond strength between the biomaterial and restorative material is crucial for minimizing bacterial microleakage and ensuring a favorable long-term prognosis for vital pulp therapy. This study aimed to conduct a comparative evaluation of the shear bond strength between calcium silicate-based biomaterials utilized in vital pulp treatment and various glass ionomer cement materials, both with and without the application of adhesive agents.

Methods
A total of 270 acrylic blocks, each featuring cavities measuring 4 mm in diameter and 2 mm in depth, were prepared. Calcium silicate-containing biomaterials (ProRoot MTA, Medcem Pure Portland Cement, and Medcem MTA), following manufacturers’ instructions, were placed within the voids in the acrylic blocks and allowed to set for the recommended durations. The biomaterial samples were randomly categorized into three groups based on the restorative material to be applied: conventional glass ionomer cement, resin-modified glass ionomer cement, and bioactive restorative material. Using cylindrical molds with a diameter of 3.2 mm and a height of 3 mm, restorative materials were applied to the biomaterials in two different methods, contingent on whether adhesive was administered. After all samples were incubated in an oven at 37 °C for 24 h, shear bond strength values were measured utilizing a universal testing device. The obtained data were statistically evaluated using ANOVA and post-hoc Tukey tests.

Results
The highest shear bond strength value was noted in the Medcem MTA + ACTIVA bioactive restorative material group with adhesive application, while the lowest shear bond strength value was observed in the ProRoot MTA White + Equia Forte HT Fil group without adhesive application (P < 0.05).

Conclusion
Activa Bioactive Restorative may be considered a suitable restorative material in combination with calcium silicate-based biomaterials for vital pulp treatment. The application of adhesives to calcium silicate-based biomaterials can effectively address the technical limitations.
Effect of bar designs on peri implant tissues health in implant-supported removable prostheses: a systematic review
Authors: Omeish Nadine , Bessou Laure , Carra Maria-Clotilde , Tavernier Bruno , Porporatti André Luís 
Published: January 2024

AbstractDifferent characteristics of bars (cross-sectional shape, diameter, distal extension etc.) lead to different biomechanical behavior (retention and stress) with implants and peri-implant tissues.Aim: To evaluate the impact of implant-supported removable prostheses bar designs in fully edentulous arch (in the maxilla and/or mandibula), with 4 implants or more, on the peri-implant soft and hard tissues.Two reviewers searched for observational studies, RCT and in vitro studies, published on five main databases and three from the grey literature, without restrictions on November 2023.Of the 3049 selected articles, four met the inclusion criteria. Four RCT evaluated peri-implant health tissues in full edentulous arches with 4 or 6 implants rehabilitated with implant bar overdentures. One prospective study with 5 years follow-up evaluated the success/survival rate of implants and implant bar overdentures. Overall, 261 subjects were enrolled in our systematic review with 1176 implants. Overdentures’ survival rate was 100%. There was a trend that plaque indices and gingival indices were low in all of the studies, however no statistical analysis was done due to the lack of information.Due to the lack of information in the included studies, we cannot confirm if bar characteristics affect the peri-implant tissues health.
Automatic dental age calculation from panoramic radiographs using deep learning: a two-stage approach with object detection and image classification
Authors: Kokomoto Kazuma , Kariya Rina , Muranaka Aya , Okawa Rena , Nakano Kazuhiko , Nozaki Kazunori 
Published: January 2024

Abstract
Background
Dental age is crucial for treatment planning in pediatric and orthodontic dentistry. Dental age calculation methods can be categorized into morphological, biochemical, and radiological methods. Radiological methods are commonly used because they are non-invasive and reproducible. When radiographs are available, dental age can be calculated by evaluating the developmental stage of permanent teeth and converting it into an estimated age using a table, or by measuring the length between some landmarks such as the tooth, root, or pulp, and substituting them into regression formulas. However, these methods heavily depend on manual time-consuming processes. In this study, we proposed a novel and completely automatic dental age calculation method using panoramic radiographs and deep learning techniques.

Methods
Overall, 8,023 panoramic radiographs were used as training data for Scaled-YOLOv4 to detect dental germs and mean average precision were evaluated. In total, 18,485 single-root and 16,313 multi-root dental germ images were used as training data for EfficientNetV2 M to classify the developmental stages of detected dental germs and Top-3 accuracy was evaluated since the adjacent stages of the dental germ looks similar and the many variations of the morphological structure can be observed between developmental stages. Scaled-YOLOv4 and EfficientNetV2 M were trained using cross-validation. We evaluated a single selection, a weighted average, and an expected value to convert the probability of developmental stage classification to dental age. One hundred and fifty-seven panoramic radiographs were used to compare automatic and manual human experts’ dental age calculations.

Results
Dental germ detection was achieved with a mean average precision of 98.26% and dental germ classifiers for single and multi-root were achieved with a Top-3 accuracy of 98.46% and 98.36%, respectively. The mean absolute errors between the automatic and manual dental age calculations using single selection, weighted average, and expected value were 0.274, 0.261, and 0.396, respectively. The weighted average was better than the other methods and was accurate by less than one developmental stage error.

Conclusion
Our study demonstrates the feasibility of automatic dental age calculation using panoramic radiographs and a two-stage deep learning approach with a clinically acceptable level of accuracy.