bluuebunny/crossref_metadata_2025_split huggingface dataset:
A model for predicting postoperative persistent acute kidney injury (AKI) in AKI after cardiac surgery patients with normal baseline renal function
Authors: Chen Yuanhan , Mo Zhiming , Chu Hong , Hu Penghua , Fan Wei , Wu Yanhua , Song Li , Zhang Li , Li Zhilian , Liu Shuangxin , Ye Zhiming , Liang Xinling 
Published: October 2023

AbstractBackgroundPersistent acute kidney injury (AKI) after cardiac surgery is not uncommon and linked to poor outcomes.HypothesisThe purpose was to develop a model for predicting postoperative persistent AKI in patients with normal baseline renal function who experienced AKI after cardiac surgery.MethodsData from 5368 patients with normal renal function at baseline who experienced AKI after cardiopulmonary bypass cardiac surgery in our hospital were retrospectively evaluated. Among them, 3768 patients were randomly assigned to develop the model, while the remaining patients were used to validate the model. The new model was developed using logistic regression with variables selected using least absolute shrinkage and selection operator regression.ResultsThe incidence of persistent AKI was 50.6% in the development group. Nine variables were selected for the model, including age, hypertension, diabetes, coronary heart disease, cardiopulmonary bypass time, AKI stage at initial diagnosis after cardiac surgery, postoperative serum magnesium level of <0.8 mmol/L, postoperative duration of mechanical ventilation, and postoperative intra‐aortic balloon pump use. The model's performance was good in the validation group. The area under the receiver operating characteristic curve was 0.761 (95% confidence interval: 0.737–0.784). Observations and predictions from the model agreed well in the calibration plot. The model was also clinically useful based on decision curve analysis.ConclusionsIt is feasible by using the model to identify persistent AKI after cardiac surgery in patients with normal baseline renal function who experienced postoperative AKI, which may aid in patient stratification and individualized precision treatment strategy.
Usefulness of endoscopic ultrasound‐guided transhepatic biliary drainage with a 22‐gauge fine‐needle aspiration needle and 0.018‐inch guidewire in the procedure's induction phase
Authors: Yane Kei , Yoshida Masahiro , Imagawa Takayuki , Morita Kotaro , Ihara Hideyuki , Hanada Kota , Hirokawa Sota , Tomita Yusuke , Minagawa Takeyoshi , Okagawa Yutaka , Sumiyoshi Tetsuya , Hirayama Michiaki , Kondo Hitoshi 
Published: October 2023

AbstractEndoscopic ultrasound (EUS)‐guided transhepatic biliary drainage is usually performed with a 19‐gauge fine‐needle aspiration (FNA) needle and a 0.025‐inch guidewire. The combination of a 22‐gauge FNA needle and a 0.018‐inch guidewire is reported to be effective as a rescue option when the bile duct diameter is small or technically challenging. Experts in EUS‐guided transhepatic biliary drainage have reported that bile duct puncture with a 19‐gauge FNA needle is possible in most cases, but is not easy to reproduce by endoscopists with less experience in EUS‐guided transhepatic biliary drainage. We investigated the usefulness of EUS‐guided transhepatic biliary drainage using a 22‐gauge FNA needle and a 0.018‐inch guidewire during the procedure's induction phase. Consecutive patients who underwent EUS‐guided transhepatic biliary drainage at our institution from March 2021 to May 2023 were evaluated, and 37 were included. Biliary drainage was performed for malignant bile duct stricture in 36 patients and choledocholithiasis in one patient. The median target bile duct diameter was 4.5 mm (2.5–9.4). Biliary access, fistula dilation, and stent placement were successful in the 37 patients (100%). The median procedure time was 35 min (16–125). Adverse events occurred in four (10.8%) patients. EUS‐guided transhepatic biliary drainage using a 22‐gauge FNA needle and a 0.018‐inch guidewire is a useful and promising option for endoscopists with limited experience in EUS‐guided transhepatic biliary drainage in the procedure's induction phase.
DABCO‐Promoted Bicyclization/Rearrangement Reaction Synthesis of Tetrasubstituted Furans and Furo[3,4‐d]pyrimidine‐2,4‐diones from 1,4‐Enediones
Authors: Zhang Wen‐Wen , Gan Shao‐Ting , Qin Zhao‐Yi , Jin Mei , Liu Shan , Shu Wen‐Ming , Wu An‐Xin 
Published: October 2023

AbstractA DABCO‐promoted bicyclization/rearrangement reaction has been developed for the synthesis of tetrasubstituted furans from 1,4‐enediones at room temperature. This transformation involves aza‐Michael addition, intramolecular bicyclization, and rearrangement processes. In addition, the 4‐ureidofuran‐3‐carboxylate ester products can further be converted to furo[3,4‐d]pyrimidine‐2,4‐diones through intramolecular substitution cyclization under heating conditions.
An Intramolecular Enyne Metathesis Approach for the Synthesis of Cyclic 3‐Substituted Unsaturated Sulfones
Authors: Lin Dandan , Sullivan Anna , Cîrceie Martha , Chiericoni Vittoria , Karpov Jaroslav , Kluza Kacper , O'Neill Niamh , Risse Wilhelm , Evans Paul 
Published: October 2023

AbstractStudies into the ring‐closing enyne metathesis of a series of nine sulfone containing enynes is described. The readily accessible sulfone substrates were shown to undergo cyclisation to form 3‐subsituted 2,5‐dihydrothiophene 1,1‐dioxides (sulfolenes) and one 3,6‐dihydro‐2H‐thiopyran 1,1‐dioxide. The success of this process depended on the substrate's substitution pattern. Moderate to good yields of the products were obtained when the ene component was monosubstituted and it was found that the reactions proceeded most efficiently using the 2nd generation Grubbs catalysts, at elevated temperatures.
The simultaneous voltammetric detection of guanine and inosine using a hybrid nanocomposite of multi‐walled carbon nanotubes and iron oxide nanoparticles
Authors: Soltani Niloufar , Noroozifar Meissam , Kerman Kagan 
Published: October 2023

AbstractIn this proof‐of‐concept study, a graphite paste electrode was modified with a novel hybrid nanocomposite of multi‐walled carbon nanotubes and iron‐oxide nanoparticles for the simultaneous voltammetric detection of guanine and inosine. The nanocomposite was characterized using transmission electron microscopy. The incorporation of iron oxide nanoparticles with multiwalled carbon nanotubes to the modified graphite paste electrode provided an enhanced electrocatalytic activity as studied by cyclic voltammetry, electrochemical impedance spectroscopy and differential pulse voltammetry. The linearity ranges were 0.1–9.0 μM and 0.5–55 μM with a detection limit of 0.05 μM and 0.12 μM for guanine and inosine, respectively. Moreover, chronoamperometric studies were carried out for the determination of diffusion coefficients, and heterogenous rate constants of guanine and inosine. The sensor was also used for the simultaneous detection of guanine and inosine in commercially available bovine serum samples with recovery values ranging from 96 % to 104 %. We envisage the nanocomposite‐modified sensor provides a promising platform for the detection of guanine and inosine in pharmaceutical formulations and biological samples as biomarkers of oxidative damage related to cancer research.
Efficacy and tolerability of dolutegravir/lamivudine versus dolutegravir/rilpivirine in switching from a three‐drug regimen based on nonnucleoside reverse transcriptase inhibitors: A retrospective cohort study
Authors: Lagi Filippo , Giacomelli Andrea , Borghi Vanni , Ciccullo Arturo , Taramasso Lucia , Madeddu Giordano , D'Ettorre Gabriella , Giacometti Andrea , Ducci Filippo , De Vito Andrea , Pincino Rachele , Di Giambenedetto Simona , Mussini Cristina , Antinori Spinello , Sterrantino Gaetana 
Published: October 2023

AbstractReal‐life comparisons of dolutegravir/rilpivirine (DTG/RPV) and DTG/lamivudine (3TC) regimens in people living with human immunodeficiency virus (PLWHIV) who switched from a standard three‐drug regimen based on nonnucleoside reverse transcriptase inhibitors (NNRTIs) are missing. This study aimed to compare DTG/3TC and DTG/RPV in virologically suppressed patients (HIV‐RNA < 50 copies/mL) coming from any NNRTI‐based regimen in terms of discontinuation due to virologic failure (VF) discontinuation rates due to all causes, and adverse events. As a secondary outcome, we evaluated the difference in creatinine, total cholesterol, CD4, and triglycerides from baseline to weeks 48 after the switch. Of the 415 PLWHs included in the study, 278 (66.9%) switched to DTG/3TC, and 137 (33.1%) switched to DTG/RPV. Overall, 48 PLWHs (11.6%) discontinued the treatment:38 with DTG/3TC and 10 with DTG/RPV with similar discontinuation rates: 5.01 × 100 py (95% confidence interval [CI] 3.64–6.94) and 4.66 × 100 py (95% CI 2.51–8.67), respectively. The most common reason for discontinuation was toxicity (26 patients, 22/278 [7.9%] in the DTG/3TC group and 4/137 [2.9%] in the DTG/RPV group), mainly neurologic toxicity (never above grade 2). We found no differences in discontinuation rates due to treatment adverse events. Two study participants experienced virological failure in the DTG/3TC arm. We observed no significant difference in CD4 cell counts, lipid parameters, or renal function between the two groups at 48 weeks. This study demonstrated that, in clinical practice, a two‐drug regimen with DTG/3TC or DTG/RPV is characterized by a low discontinuation rate and VF in virologically suppressed PLWHs switched from an NNRTI‐based three antiretroviral drugs regimen.
Insight into the effect of large yellow croaker roe phospholipids on the physical properties of surimi gel and their interaction mechanism with myofibrillar protein
Authors: Du Yanyu , Lan Jiaojiao , Zhong Rongbin , Shi Feifei , Yang Qian , Liang Peng 
Published: October 2023

AbstractBACKGROUNDThe present study aimed to investigate the effects of large yellow croaker roe phospholipids (LYCRPLs) on the physical properties of surimi gels and to clarify their interaction mechanism with myofibrillar proteins (MPs) in terms of chemical forces and the spatial conformation.RESULTSLYCRPLs could improve the gel strength, textural properties, rheological properties and water‐holding capacity of surimi gels. Moreover, the interaction mechanism between LYCRPLs with MPs was revealed through intermolecular forces, Fourier transform infrared spectroscopy and ultraviolet visible absorption spectroscopy. The findings demonstrated that LYCRPLs enhanced the surface hydrophobicity and particle size of MPs, facilitating expansion and cross‐linking of MPs.CONCLUSIONThese results provide a theoretical basis for improving the characteristics of surimi gels and thus facilitate the application of LYCRPLs in the aquatic food industry. © 2023 Society of Chemical Industry.
A repository of grade 1 and 2 meningioma MRIs in a public dataset for radiomics reproducibility tests
Authors: Vassantachart April , Cao Yufeng , Shen Zhilei , Cheng Karen , Gribble Michael , Ye Jason C. , Zada Gabriel , Hurth Kyle , Mathew Anna , Guzman Samuel , Yang Wensha 
Published: October 2023

AbstractPurposeMeningiomas are the most common primary brain tumors in adults with management varying widely based on World Health Organization (WHO) grade. However, there are limited datasets available for researchers to develop and validate radiomic models. The purpose of our manuscript is to report on the first dataset of meningiomas in The Cancer Imaging Archive (TCIA).Acquisition and validation methodsThe dataset consists of pre‐operative MRIs from 96 patients with meningiomas who underwent resection from 2010–2019 and include axial T1post and T2‐FLAIR sequences—55 grade 1 and 41 grade 2. Meningioma grade was confirmed based on the 2016 WHO Bluebook classification guideline by two neuropathologists and one neuropathology fellow. The hyperintense T1post tumor and hyperintense T2‐FLAIR regions were manually contoured on both sequences and resampled to an isotropic resolution of 1 × 1 × 1 mm3. The entire dataset was reviewed by a certified medical physicist.Data format and usage notesThe data was imported into TCIA for storage and can be accessed at https://doi.org/10.7937/0TKV‐1A36. The total size of the dataset is 8.8GB, with 47 519 individual Digital Imaging and Communications in Medicine (DICOM) files consisting of 384 image series, and 192 structures.Potential applicationsGrade 1 and 2 meningiomas have different treatment paradigms and are often treated based on radiologic diagnosis alone. Therefore, predicting grade prior to treatment is essential in clinical decision‐making. This dataset will allow researchers to create models to auto‐differentiate grade 1 and 2 meningiomas as well as evaluate for other pathologic features including mitotic index, brain invasion, and atypical features. Limitations of this study are the small sample size and inclusion of only two MRI sequences. However, there are no meningioma datasets on TCIA and limited datasets elsewhere although meningiomas are the most common intracranial tumor in adults.
A novel, end‐to‐end framework for avoiding collisions between the patient's body and gantry in proton therapy
Authors: Yamazaki Yuhei , Terunuma Toshiyuki , Kato Takahiro , Komori Shinya , Sakae Takeji 
Published: October 2023

AbstractBackgroundAdministration of external radiation therapy via proton therapy systems carries a risk of occasional collisions between the patient's body and gantry, which is increased by the snout placed near the patient for better dose distribution. Although treatment planning software (TPS) can simulate controlled collisions, the computed tomography (CT) data used for treatment planning are insufficient given that collisions can occur outside the CT imaging region. Thus, imaging the three‐dimensional (3D) surface outside the CT range and combining the data with those obtained by CT are essential for avoiding collisions.PurposeTo construct a prototype for 3D surface imaging and an end‐to‐end framework for preventing collisions between the patient's body and the gantry.MethodsWe obtained 3D surface data using a light sectioning method (LSM). By installing only cameras in front of the CT, we achieved LSM using the CT couch motion and preinstalled patient‐positioning lasers. The camera image contained both sagittal and coronal lines, which are unnecessary for LSM and were removed by deep learning. We combined LSM 3D surface data and original CT data to create synthetic Digital Imaging and Communications in Medicine (DICOM) data. Subsequently, we compared the TPS snout auto‐optimization using the original CT data with the synthetic DICOM data.ResultsThe mean positional error for LSM of the arms and head was 0.7 ± 0.8 and 0.8 ± 0.8 mm for axial and sagittal imaging, respectively. The TPS snout auto‐optimization indicated that the original CT data would cause collisions; however, the synthetic DICOM data prevented these collisions.ConclusionsThe prototype system's acquisition accuracy for 3D surface data was approximately 1 mm, which was sufficient for the collision simulation. The use of a TPS with collision avoidance can help optimize the snout position using synthetic DICOM data. Our proposed method requires no external software for collision simulation and can be integrated into the clinical workflow to improve treatment planning efficiency.
A case of tuberculous pleurisy characterized by bleeding and necrosis documented by medical thoracoscope
Authors: Zhang Minlong , Yang Cuiping , Guo Yinghua 
Published: October 2023

Key messageTuberculous pleurisy is a main cause of pleural effusions. The main histological abnormalities in pleural biopsy of tuberculous pleurisy are caseating granulomas and epithelioid cell granuloma. In our case, chronic inflammation of fibrous tissue with bleeding, necrosis, and exudation were observed during a medical thoracoscopy as manifestations of tuberculous pleurisy.
Neugeborenen-Screening aus Trockenblut (NBS) in Deutschland
Authors: Nennstiel Uta , Odenwald Birgit , Throner Veronika , Blankenstein Oliver , Vieth Andreas , Ratzel Rudolf , Coenen Michaela , Brockow Inken 
Published: October 2023

ZusammenfassungDas Neugeborenen-Screening aus Trockenblut (Newborn Blood Spot Screening, NBS) ist eine seit vielen Jahren etablierte hocheffektive Maßnahme der Sekundärprävention. Aufgrund der Entwicklung neuer diagnostischer und therapeutischer Möglichkeiten für seltene angeborene Krankheiten ist davon auszugehen, dass in Zukunft weitere Zielkrankheiten in das NBS aufgenommen werden. Vor diesem Hintergrund wurde im Auftrag des GKV-Spitzenverbandes ein Konzept für die Weiterentwicklung des NBS entwickelt. Als Grundlage hierfür dienten eine systematische Literaturrecherche und die Erhebung des Status quo in Deutschland anhand von quantitativen und qualitativen Methoden.Entscheidend für den Erfolg des NBS ist, dass möglichst alle von einer Zielkrankheit betroffenen Neugeborenen frühzeitig diagnostiziert und behandelt werden und der bei jedem Screening zu erwartende Schaden (z. B. durch falsch-positive Befunde) möglichst gering gehalten wird. Hierfür ist die Organisation des Screenings im Sinne eines integrierten Programms durch eine zentrale Koordination mit standardisierten Strukturen, kontinuierlichem Qualitätsmanagement und einer datenschutzkonformen Digitalisierung erforderlich.Obwohl das NBS in Deutschland insgesamt erfolgreich umgesetzt wird, zeigen sich im Rahmen des hier vorgestellten Forschungsprojekts auch Schwächen und Handlungsbedarf. Erarbeitete Vorschläge und Empfehlungen wurden in einem Konzeptpapier festgehalten, das Ansätze für eine dem aktuellen Forschungsstand entsprechende Weiterentwicklung des NBS aufzeigt und dabei sich ändernde Anforderungen an die Infrastruktur und Prozesse im Gesundheitssystem berücksichtigt. In diesem Übersichtsartikel werden Herausforderungen, aktueller Stand und Lösungsansätze zu zentralen Themenfeldern des Konzeptpapiers zusammenfassend dargestellt.
Identifying QTLs involved in hybrid performance and heterotic group complementarity: new GWAS models applied to factorial and admixed diallel maize hybrid panels
Authors: Beugnot Aurélien , Mary-Huard Tristan , Bauland Cyril , Combes Valerie , Madur Delphine , Lagardère Bernard , Palaffre Carine , Charcosset Alain , Moreau Laurence , Fievet Julie B. 
Published: October 2023

Abstract
Key message
An original GWAS model integrating the ancestry of alleles was proposed and allowed the detection of background specific additive and dominance QTLs involved in heterotic group complementarity and hybrid performance.

Abstract
Maize genetic diversity is structured into genetic groups selected and improved relative to each other. This process increases group complementarity and differentiation over time and ensures that the hybrids produced from inter-group crosses exhibit high performances and heterosis. To identify loci involved in hybrid performance and heterotic group complementarity, we introduced an original association study model that disentangles allelic effects from the heterotic group origin of the alleles and compared it with a conventional additive/dominance model. This new model was applied on a factorial between Dent and Flint lines and a diallel between Dent-Flint admixed lines with two different layers of analysis: within each environment and in a multiple-environment context. We identified several strong additive QTLs for all traits, including some well-known additive QTLs for flowering time (in the region of Vgt1/2 on chromosome 8). Yield trait displayed significant non-additive effects in the diallel panel. Most of the detected Yield QTLs exhibited overdominance or, more likely, pseudo-overdominance effects. Apparent overdominance at these QTLs contributed to a part of the genetic group complementarity. The comparison between environments revealed a higher stability of additive QTL effects than non-additive ones. Several QTLs showed variations of effects according to the local heterotic group origin. We also revealed large chromosomic regions that display genetic group origin effects. Altogether, our results illustrate how admixed panels combined with dedicated GWAS modeling allow the identification of new QTLs that could not be revealed by a classical hybrid panel analyzed with traditional modeling.
Trends in prescribing and outcomes in obese versus non-obese patients receiving rivaroxaban therapy: an observational study using real-world data
Authors: Alalawneh Majdoleen , Rachid Ousama , Abdallah Ibtihal , Mahfouz Ahmed , Elewa Hazem , Danjuma Mohammed Ibn-Mas‘ud , Mohamed Asmaa Ezzeldin , Awaisu Ahmed 
Published: October 2023

Abstract
Purpose
To investigate real-world prescribing trends and clinical outcomes based on body mass index (BMI) categorization in patients who received rivaroxaban therapy.

Methods
This was a retrospective cohort study involving all patients who received rivaroxaban therapy across all Hamad Medical Corporation (HMC) hospitals from 2015 to 2020.

Results
The number of patients initiated on rivaroxaban therapy significantly increased from 152 (3.3%) in 2015 to 1342 (28.9%) in 2020 (p <0.001). Within BMI categories, a similar increasing trend was observed in underweight, normal, and overweight patients, while from 2018 to 2020, there was a decreasing trend in rivaroxaban prescribing in all obese classes. The prevalence rate of all-cause mortality differed significantly between the BMI groups, with the highest mortality being among morbidly obese patients (BMI ≥ 40 kg/m2) (p< 0.001). On the other hand, no significant differences were found between the BMI groups in terms of bleeding, pulmonary embolism, deep vein thrombosis and stroke incidences. Multivariate logistic regression analyses showed that the likelihood of all-cause mortality was significantly higher in overweight and all categories of obese patients compared to underweight patients: overweight (OR: 5.3, 95% CI: 2.3–11.9, p< 0.001); obese class 1 (OR: 5.4, 95% CI: 2.3 – 12.2, p< 0.001); obese class 2 (OR: 6.5, 95% CI: 2.7 – 15.6, p< 0.001); and obese class 3 (OR: 3.7, 95% CI: 1.6 – 8.7, p = 0.003).

Conclusions
Rivaroxaban prescribing has significantly increased over the years across general population, with a noticeable decline in obese population during the last few years (from 2018 onwards). Furthermore, an appreciable association was evident between all-cause mortality and BMI of these patients.
The Timing of Operative Intervention for Pediatric Burn Patients in Malawi
Authors: Davis Dylane , An Selena , Kayange Linda , Wolf Lindsey , Boddie Olivia , Charles Anthony , Gallaher Jared 
Published: October 2023

AbstractBackgroundDefining the optimal timing of operative intervention for pediatric burn patients in a resource‐limited environment is challenging. We sought to characterize the association between mortality and the timing of operative intervention at a burn center in Lilongwe, Malawi.MethodsThis is a retrospective analysis of burn patients (<18 years old) presenting to Kamuzu Central Hospital from 2011 to 2022. We compared patients who underwent excision and/or burn grafting based on the timing of the operation. We used logistic regression modeling to estimate the adjusted odds ratio of death based on the timing of surgery.ResultsWe included 2502 patients with a median age of 3 years (IQR 1–5) and a male preponderance (56.8%). 411 patients (16.4%) had surgery with a median time to surgery of 18 days (IQR 8–34). The crude mortality rate among all patients was 17.0% and 9.1% among the operative cohort. The odds ratio of mortality for patients undergoing surgery within 3 days from presentation was 5.00 (95% CI 2.19, 11.44) after adjusting for age, sex, % total burn surface area (TBSA), and flame burn. The risk was highest for the youngest patients.ConclusionsChildren who underwent burn excision and/or grafting in the first 3 days of hospitalization had a much higher risk of death than patients undergoing surgical intervention later. Delaying operative intervention till >72 h for pediatric patients, especially those under 5 years old, may confer a survival advantage. More investment is needed in early resuscitation and monitoring for this patient population.