bluuebunny/crossref_metadata_2025_split huggingface dataset:
A novel film based on a cellulose/sodium alginate/gelatin composite activated with an ethanolic fraction of Boswellia sacra oleo gum resin
Authors: Bhatia Saurabh , Shah Yasir Abbas , Al‐Harrasi Ahmed , Ullah Sana , Anwer Md Khalid , Koca Esra , Aydemir Levent Yurdaer , Khan Mahbubar Rahman 
Published: December 2023

AbstractBoswellia sacra and its derivatives exhibit notable bioactive properties, which have been the subject of extensive scientific research; however, their potential applications in food packaging remain largely untapped. In the current study, cellulose, sodium alginate, and gelatin composite edible films were fabricated with the addition of different concentrations (0.2% and 0.3%) of the ethanolic fraction of Boswellia sacra oleo gum resin (BSOR). The resultant films were examined for their physical, chemical, mechanical, barrier, optical, and antioxidant properties. Moreover, the films were characterized using Scanning Electron Microscopy (SEM), X‐ray diffraction (XRD), and Fourier transform infrared spectroscopy (FTIR) to study the impact of incorporating BSOR on the morphological, crystalline, and chemical properties of the films. The addition of BSOR increased the film thickness (0.026–0.08 mm), water vapor permeability (0.210–0.619 (g.mm)/(m2.h.kPa), and the intensity of the yellow color (3.01–7.20) while reducing the values of both tensile strength (6.67–1.03 MPa) and elongation at break (83.50%–48.81%). SEM and FTIR analysis confirmed the interaction between the BSOR and film‐forming components. The antioxidant properties of the edible films were significantly increased with the addition of BSOR. The comprehensive findings of the study demonstrated that BSOR possesses the potential to serve as an efficient natural antioxidant agent in the fabrication of edible films.
Synthesis of N‐Doped Graphene Photo‐Catalyst for Photo‐Assisted Charging of Li‐Ion Oxygen Battery
Authors: Kaçar Nilay , Lökçü Ersu , Çayirli Meltem , Özden Reşat Can , Coskun Sahin , Toparli Cigdem , Çelikyürek İbrahim , Anik Mustafa 
Published: December 2023

AbstractIn this work, nitrogen (N)‐doped graphene film is synthesized, as a photo‐catalyst, on one side of the copper foam by chemical vapor deposition and the copper foam is directly used as an electrode after porous Pd@rGO cathode loading to the other side of the foam for the photo‐assisted charging of the Li‐ion oxygen battery. The amount of urea (CO(NH2)2), which is used as N atom source, is optimized to get maximum photo‐anodic currents from the n‐type graphene films. The optical band gap and the valance band edge potential of the optimized N‐doped graphene film are determined as 2.00 eV and 3.71 VLi+/Li, respectively. X‐ray photoelectron spectra provided that the atomic percent of N atoms in the graphene film is 1.34% and the graphitic, pyrrolic and pyridinic N atom percentages are 54.01%, 42.20% and 3.79%, respectively. The photo‐assisted charging tests indicated that the N‐doped graphene film photo‐catalyst reduced the charging potential significantly even at 1000 mA g−1 (0.1 mA cm−2) current density and improved the cyclic discharge‐charge performance of the Li‐ion oxygen battery considerably.
Ba3(PO4)2 Photocatalyst for Efficient Photocatalytic Application
Authors: Naciri Yassine , Ahdour Ayoub , Benhsina Elhassan , Hamza Mahmoud Adel , Bouziani Asmae , Hsini Abdelghani , Bakiz Bahcine , Navío Jose Antonio , Ghazzal Mohamed Nawfal 
Published: December 2023

AbstractBarium phosphate (Ba3(PO4)2) is a class of material that has attracted significant attention thanks to its chemical stability and versatility. However, the use of Ba3(PO4)2 as a photocatalyst is scarcely reported, and its use as a photocatalyst has yet to be reported. Herein, Ba3(PO4)2 nanoflakes synthesis is optimized using sol‐gel and hydrothermal methods. The as‐prepared Ba3(PO4)2 powders are investigated using physicochemical characterizations, including XRD, SEM, EDX, FTIR, DRS, J–t, LSV, Mott‐Schottky, and EIS. In addition, DFT calculations are performed to investigate the band structure. The oxidation capability of the photocatalysts is investigated depending on the synthesis method using rhodamine B (RhB) as a pollutant model. Both Ba3(PO4)2 samples prepared by the sol‐gel and hydrothermal methods display high RhB photodegradation of 79% and 68%, respectively. The Ba3(PO4)2 obtained using the sol‐gel process exhibits much higher stability under light excitation after four regeneration cycles. The photocatalytic oxidation mechanism is proposed based on the active species trapping experiments where O2•‒ is the most reactive species. The finding shows the promising potential of Ba3(PO4)2 photocatalysts and opens the door for further investigation and application in various photocatalytic applications.
Predictive modeling of energy‐related greenhouse gas emissions in Ghana towards a net‐zero future
Authors: Sokama‐Neuyam Yen Adams , Amezah Samuel Mawulikem , Adjei Stephen , Adenutsi Caspar Daniel , Erzuah Samuel , Quaye Jonathan Atuquaye , Ampomah William , Sarkodie Kwame 
Published: December 2023

AbstractGhana is determined to reduce greenhouse gas (GHG) emissions by at least 15% by 2030 and attain net‐zero emissions by 2070. However, like many developing countries, Ghana must utilize its limited resources effectively to actualize its climate goals. Currently, climate policies in the country are not driven by emission data, which has important implications on effective utilization of resources and selection of efficient mitigation techniques. We analyzed energy consumption and GHG emission data between 1990 and 2016 from Ghana's energy sector which is responsible for about 36% of the country's total emissions. Predictive models were then developed using machine learning to forecast energy related emissions up to 2030. Based on the analysis and projections, attainable data‐driven recommendations were proposed to direct climate policies in the country. We found that between 1990 and 2016, petroleum fuel consumption increased by about 64.5% and the corresponding GHG emissions increased by 303%. The projections suggests that by 2030, energy sector emissions could increase by 131% compared to 2016 levels. Transport sector emission is also projected to increase by a whopping 219% and fuel consumption could hit 6742 ktoe by 2030, which is about 106% increase from the 2016 benchmark. The findings from this work will direct policy for effective mitigation of GHG emissions in the country while ensuring effective utilization of climate resources to pursue its net‐zero targets. © 2023 Society of Chemical Industry and John Wiley & Sons, Ltd.
Previous pregnancies might mitigate cortical brain differences associated with surgical menopause
Authors: Fernández‐Pena Alberto , Navas‐Sánchez Francisco J. , de Blas Daniel Martín , Marcos‐Vidal Luis , Desco Manuel , Carmona Susanna 
Published: December 2023

AbstractSurgical menopause causes a sharp drop in estrogen levels in middle‐aged women, thus preventing the gradual physiological adaptation that is characteristic of the perimenopause. Previous studies suggest that surgical menopause might increase the risk of dementia later in life. In addition, the transition to motherhood entails long‐lasting endocrine and neuronal adaptations. We compared differences in whole‐brain cortical volume between women who reached menopause by surgery and a group of women who reached spontaneous non‐surgical menopause and determined whether these cortical differences were influenced by previous childbearing. Using surface‐based neuroimaging techniques, we investigated cortical volume differences in 201 middle‐aged women (134 women who experienced non‐surgical menopause, 78 of whom were parous women; and 67 women who experienced surgical menopause, 39 of whom were parous women). We found significant atrophy in the frontal and temporal regions in women who experienced surgical menopause. Nulliparous women with surgical menopause showed significant lower cortical volume in the left temporal gyrus extending to the medial temporal lobe cortex, as well as in the precuneus bilaterally compared to parous women with surgical menopause; whereas our results revealed no significant differences between parous women with surgical menopause and both parous and nulliparous women who reached a non‐surgical menopause. Furthermore, in the surgical menopause group, we found a negative correlation between cortical volume and age at first pregnancy in the temporal lobe. Our study suggests that the long‐term brain remodeling of parity may mitigate the neural impact of the sudden drop in estrogen levels that characterizes surgical menopause.
Incorporation of climate change into a multiple stressor risk assessment for the Chinook salmon (Oncorhynchus tshawytscha) population in the Yakima River, Washington, USA
Authors: Landis Wayne G. , Mitchell Chelsea J. , Hader John D. , Nathan Rory , Sharpe Emma E. 
Published: December 2023

Abstract
One outcome of the 2022 Society of Environmental Toxicology and Chemistry Pellston Workshop on incorporating climate change predictions into ecological risk assessments was the key question of how to integrate ecological risk assessments that focus on contaminants with the environmental alterations from climate projections. This article summarizes the results of integrating selected direct and indirect effects of climate change into an existing Bayesian network previously used for ecological risk assessment. The existing Bayesian Network Relative Risk Model integrated the effects of two organophosphate pesticides (malathion and diazinon), water temperature, and dissolved oxygen levels on the Chinook salmon population in the Yakima River Basin (YRB), Washington, USA. The endpoint was defined as the entity, Yakima River metapopulation, and the attribute was defined as no decline to a subpopulation or the overall metapopulation. In this manner, we addressed the management objective of no net loss of Chinook salmon, an iconic and protected species. Climate change-induced changes in water quality parameters (temperature and dissolved oxygen levels) used models based on projected climatic conditions in the 2050s and 2080s by the use of a probabilistic model. Pesticide concentrations in the original model were modified assuming different scenarios of pest control strategies in the future, because climate change may alter pest numbers and species. Our results predict that future direct and indirect changes to the YRB will result in a greater probability that the salmon population will continue to fail to meet the management objective of no net loss. As indicated by the sensitivity analysis, the key driver in salmon population risk was found to be current and future changes in temperature and dissolved oxygen, with pesticide concentrations being not as important. Integr Environ Assess Manag 2024;20:419–432. © 2023 The Authors. Integrated Environmental Assessment and Management published by Wiley Periodicals LLC on behalf of Society of Environmental Toxicology & Chemistry (SETAC).
Global burden of 34 cancers among women in 2020 and projections to 2040: Population‐based data from 185 countries/territories
Authors: Bizuayehu Habtamu Mellie , Dadi Abel F. , Hassen Tahir A. , Ketema Daniel Bekele , Ahmed Kedir Y. , Kassa Zemenu Y. , Amsalu Erkihun , Kibret Getiye Dejenu , Alemu Addisu Alehegn , Alebel Animut , Shifa Jemal E. , Assefa Yibeltal , Tessema Gizachew A. , Sarich Peter , Gebremedhin Aster Ferede , Bore Meless G. 
Published: December 2023

AbstractGlobally women face inequality in cancer outcomes; for example, smaller improvements in life expectancy due to decreased cancer‐related deaths than men (0.5 vs 0.8 years, 1981–2010). However, comprehensive global evidence on the burden of cancer among women (including by reproductive age spectrum) as well as disparities by region, remains limited. This study aimed to address these evidence gaps by considering 34 cancer types in 2020 and their projections for 2040. The cancer burden among women in 2020 was estimated using population‐based data from 185 countries/territories sourced from GLOBOCAN. Mortality to Incidence Ratios (MIR), a proxy for survival, were estimated by dividing the age‐standardised mortality rates by the age‐standardised incidence rates. Demographic projections were performed to 2040. In 2020, there were an estimated 9.3 million cancer cases and 4.4 million cancer deaths globally. Projections showed an increase to 13.3 million (↑44%) and 7.1 million (↑60%) in 2040, respectively, with larger proportional increases in low‐ and middle‐income countries. MIR among women was higher (poorer survival) in rare cancers and with increasing age. Countries with low Human Development Indexes (HDIs) had higher MIRs (69%) than countries with very high HDIs (30%). There was inequality in cancer incidence and mortality worldwide among women in 2020, which will further widen by 2040. Implementing cancer prevention efforts and providing basic cancer treatments by expanding universal health coverage through a human rights approach, expanding early screening opportunities and strengthening medical infrastructure are key to improving and ensuring equity in cancer control and outcomes.
Influence of ovarian cysts on ovarian reserve and fertility: A case–control study
Authors: Bareghamyan Hasmik , Chopikyan Armine , Petrosyan Marine , Shahverdyan Nune , Harutyunyan Armine 
Published: December 2023

AbstractObjectiveThe aim of this study was to evaluate the impact of having an ovarian cyst and undergoing cystectomy on the expression of ovarian reserve markers among adolescent females who live in Armenia.MethodsWe conducted a prospective case–control study. Cases were arranged into two groups. The postoperative group (POG) included those who underwent unilateral ovarian cystectomy, and those in the benign ovarian cyst group (BOCG) had complex ovarian cysts with a diameter of 5 cm or more. Adolescents without ovarian pathologies were included in the reference group (RFG). Levels of anti‐Mullerian hormone (AMH) and follicular stimulating hormone (FSH) were measured, and an ultrasound investigation of antral follicular count (AFC) was also done.ResultsMean differences between baseline and 6‐month follow‐up levels of AMH, AFC significantly decreased in both the POG and BOCG compared to the RFG. However, the decrease was more significant in the POG: a decrease of 0.86 ng/mL for AMH and 3.11 ng/mL for AFC versus decreasing by 0.61 ng/mL for AMH and 1.68 ng/mL for AFC. Meanwhile, in the BOCG, 6‐month FSH levels did not show any significant changes compared to the baseline measurement. In comparison with the reference group, there was a significant decrease in the levels of AMH and AFC among participants who had endometriomas and cystadenomas.ConclusionBenign ovarian cysts 5 cm or more in diameter, as well as cystectomy, statistically affect OR after 6 months. Therefore, adolescents with ovarian cyst or cystectomy need individualized support to maintain reproductive age fertility.
Comparative effect of different irrigation levels and soil amendments on cabbage productivity in semi‐arid Central Namibia
Authors: Enguwa Kuume B. P. , Horn Lydia N. , Awala Simon K. 
Published: December 2023

AbstractIn semi‐arid Central Namibia, poor sandy soils limit sustainable crop production. We assessed cabbage performance in two split‐plot field experiments. In Experiment 1, treatments comprised two irrigation levels: full irrigation (watered 3 days a week) and reduced irrigation (watered 2 days a week) as the main plot factor and six soil amendments (biochar; compost; zeolite; nitrogen, phosphorus potassium [NPK]; Be‐Grow boost [L] hydrogel; and hoof and horn + bone [HHB] meal) as subplot factors in three replications. Full irrigation produced a significantly higher yield (21.1 t ha−1), head weight (0.958 kg) and larger head girths (42.1 cm). Biochar produced the highest marketable heads (24,884 heads ha−1), water use efficiency (76.0 kg ha−1 mm−1) and the largest head girths (42.7 cm). In Experiment 2, water was applied 5 and 4 days a week for full and reduced irrigation; the application rates of compost, HHB meal, Be‐Grow boost (L) hydrogel and NPK were modified. The interaction of Be‐Grow boost (L) hydrogel, NPK and biochar with full irrigation and HHB meal with reduced irrigation produced more marketable heads (28,935, 28,009, 27,546 and 28,703 heads ha−1, respectively). Therefore, full irrigation with these amendments could be used for resilient cabbage production in Central Namibia.
The Dietary Fiber Inulin Slows Progression of Chronic Kidney Disease–Mineral Bone Disorder (CKD‐MBD) in a Rat Model of CKD
Authors: Biruete Annabel , Chen Neal X. , Metzger Corinne E. , Srinivasan Shruthi , O'Neill Kalisha , Fallen Paul B. , Fonseca Austin , Wilson Hannah E. , de Loor Henriette , Evenepoel Pieter , Swanson Kelly S. , Allen Matthew R. , Moe Sharon M. 
Published: December 2023

AbstractChronic kidney disease (CKD)–mineral bone disorder (CKD‐MBD) leads to fractures and cardiovascular disease. Observational studies suggest beneficial effects of dietary fiber on both bone and cardiovascular outcomes, but the effect of fiber on CKD‐MBD is unknown. To determine the effect of fiber on CKD‐MBD, we fed the Cy/+ rat with progressive CKD a casein‐based diet of 0.7% phosphate with 10% inulin (fermentable fiber) or cellulose (non‐fermentable fiber) from 22 weeks to either 30 or 32 weeks of age (~30% and ~15% of normal kidney function; CKD 4 and 5). We assessed CKD‐MBD end points of biochemistry, bone quantity and quality, cardiovascular health, and cecal microbiota and serum gut‐derived uremic toxins. Results were analyzed by two‐way analysis of variance (ANOVA) to evaluate the main effects of CKD stage and inulin, and their interaction. The results showed that in CKD animals, inulin did not alter kidney function but reduced the increase from stage 4 to 5 in serum levels of phosphate and parathyroid hormone, but not fibroblast growth factor‐23 (FGF23). Bone turnover and cortical bone parameters were similarly improved but mechanical properties were not altered. Inulin slowed progression of aorta and cardiac calcification, left ventricular mass index, and fibrosis. To understand the mechanism, we assessed intestinal microbiota and found changes in alpha and beta diversity and significant changes in several taxa with inulin, together with a reduction in circulating gut derived uremic toxins such as indoxyl sulfate and short‐chain fatty acids. In conclusion, the addition of the fermentable fiber inulin to the diet of CKD rats led to a slowed progression of CKD‐MBD without affecting kidney function, likely mediated by changes in the gut microbiota composition and lowered gut‐derived uremic toxins. © 2023 The Authors. JBMR Plus published by Wiley Periodicals LLC. on behalf of American Society for Bone and Mineral Research.
Disulfidptosis‐related PABPC3 promotes tumor progression and inhibits immune activity in osteosarcoma
Authors: Cao Yangbo , Wu Song , Gu Yishan , Wong Yung Hou , Shi Yanbin , Zhang Lina 
Published: December 2023

AbstractBackgroundOsteosarcoma is a very aggressive bone tumor mainly affecting teens and young adults. Disulfidptosis is a metabolic‐related form of regulated cell death. However, the interconnection between disulfidptosis and osteosarcoma has not been explored.MethodsIn the present study, disulfidptosis‐related clusters were identified in osteosarcoma using the nonnegative matrix factorization clustering method. PABPC3 was identified as a hazardous gene in osteosarcoma using machine learning algorithms, CoxBoost, and Random Survival Forest. The prognostic value, pathway annotation, immune characteristics, and drug prediction of PABPC3 were systematically explored. MTT (i.e., 3‐(4, 5‐dimethyl thiazol‐2‐yl)‐2,5‐diphenytetrazolium bromide), EdU (ie. 5‐ethyny‐2'‐deoxvuridine), and Transwell assays were used for in vitro validation of PABPC3.ResultsThe disulfidptosis‐related clusters could distinguish survival outcomes of osteosarcoma patients. PABPC3 could predict survival outcomes, immune activity, and drug response in osteosarcoma patients. Besides, PABPC3 was proven to facilitate the proliferation and migration of osteosarcoma.ConclusionsThe present study is expected to establish the bridge between disulfidptosis and osteosarcoma. PABPC3 is expected to be further explored as a therapeutic target in osteosarcoma.
Posttranslational modifications of ACE2 protein: Implications for SARS‐CoV‐2 infection and beyond
Authors: Xiao Yingzi , Chang Le , Ji Huimin , Sun Huizhen , Song Shi , Feng Kaihao , Nuermaimaiti Abudulimutailipu , Halemubieke Shana , Mei Ling , Lu Zhuoqun , Yan Ying , Wang Lunan 
Published: December 2023

AbstractThe present worldwide pandemic of coronavirus disease 2019 (COVID‐19) has highlighted the important function of angiotensin‐converting enzyme 2 (ACE2) as a receptor for severe acute respiratory syndrome coronavirus 2 (SARS‐CoV‐2) entry. A deeper understanding of ACE2 could offer insights into the mechanisms of SARS‐CoV‐2 infection. While ACE2 is subject to regulation by various factors in vivo, current research in this area is insufficient to fully elucidate the corresponding pathways of control. Posttranslational modification (PTM) is a powerful tool for broadening the variety of proteins. The PTM study of ACE2 will help us to make up for the deficiency in the regulation of protein synthesis and translation. However, research on PTM‐related aspects of ACE2 remains limited, mostly focused on glycosylation. Accordingly, a comprehensive review of ACE2 PTMs could help us better understand the infection process and provide a basis for the treatment of COVID‐19 and beyond.
A phenotypically robust model of spinal and bulbar muscular atrophy in Drosophila
Authors: Richardson Kristin , Sengupta Medha , Sujkowski Alyson , Libohova Kozeta , Harris Autumn C. , Wessells Robert , Merry Diane E. , Todi Sokol V. 
Published: December 2023

AbstractSpinal and bulbar muscular atrophy (SBMA) is an X‐linked disorder that affects males who inherit the androgen receptor (AR) gene with an abnormal CAG triplet repeat expansion. The resulting protein contains an elongated polyglutamine (polyQ) tract and causes motor neuron degeneration in an androgen‐dependent manner. The precise molecular sequelae of SBMA are unclear. To assist with its investigation and the identification of therapeutic options, we report here a new model of SBMA in Drosophila melanogaster. We generated transgenic flies that express the full‐length, human AR with a wild‐type or pathogenic polyQ repeat. Each transgene is inserted into the same safe harbor site on the third chromosome of the fly as a single copy and in the same orientation. Expression of pathogenic AR, but not of its wild‐type variant, in neurons or muscles leads to consistent, progressive defects in longevity and motility that are concomitant with polyQ‐expanded AR protein aggregation and reduced complexity in neuromuscular junctions. Additional assays show adult fly eye abnormalities associated with the pathogenic AR species. The detrimental effects of pathogenic AR are accentuated by feeding flies the androgen, dihydrotestosterone. This new, robust SBMA model can be a valuable tool toward future investigations of this incurable disease.