bluuebunny/crossref_metadata_2025_split huggingface dataset:
Event‐triggered adaptive neural network control design for stochastic nonlinear systems with output constraint
Authors: Shen Fei , Wang Xinjun , Pan Xinxin 
Published: November 2023

SummaryThis paper is concerned with the adaptive neural network event‐triggered control (ETC) problem for stochastic nonlinear systems with output constraint. The influence of stochastic disturbance inevitably exists in many practical systems, which leads to system instability. Meanwhile, a novel tan type barrier Lyapunov function (Tan‐BLF) structure is proposed to deal with the constraint requirements of stochastic systems. In the sense of probability, the output constraints will not be violated during the operation of the system. In addition, the ETC strategy is adopted to reduce the burden of communication. The asymptotic stability of the closed‐loop system is guaranteed without violating output constraints. Meanwhile, the tracking error converges to a small region of the origin. Two simulations results demonstrate the effectiveness of theoretical analysis.
More Than Metal–Organic Frameworks: Intestinal Villi‐Inspired Device as a Therapeutic Platform for Oral Enzyme Delivery
Authors: Qi Xiaoyue , Liu Kexin , Chen Qizhe , Deng Yulin 
Published: November 2023

AbstractMacromolecules are fragile when orally administered. An intestinal villi‐inspired metal–organic frameworks (MOFs)‐based smart pill with multiple advantages is developed to offer a salubrious solution for oral delivery of enzymes. In the pill, MOFs accommodate enzymes as carriers exhibit excellent in vitro and in vivo catalytic activities with good oral biosafety, displaying supreme protection from degradation or inhibition in simulated gastrointestinal tract and high tolerance in simulated gastric acid and intestinal fluid. Moreover, the bioinspired pill possesses the morphology of the small intestinal villi obtained via an in situ moulding strategy for enhancing biocatalysis, which is attributed to the increase of surface area. Collaboratively, the adhesive layer renders increased smart pill in vivo retention, which is verified in pigs, providing a clinically translational and versatile platform for long‐term oral macromolecule delivery.
Ultrasensitive Bidirectional Photoresponse SnSe2 Photodetector Integration with Thin‐Film Lithium Niobate Photonics
Authors: Chen Jiamin , Lu Shijia , Hu Youtian , Yang Fan , Han Huangpu , Kong Lingbing , He Bin , Ruan Shuangchen , Xiang Bingxi 
Published: November 2023

AbstractPhotodetectors (PDs) based on 2D materials are promising for photonics integration, offering fast response times, high responsivities, and low‐noise detection across a wide range of wavelengths. Here, a novel PD structure consisting of a 35‐nm‐thick SnSe2 layer covering a proton‐exchanged thin‐film lithium niobate (TFLN) waveguide is presented. This device displays ultrasensitive bidirectional photoresponse characteristics at various wavelengths and can detect photon energies below the SnSe2 bandgap. Under irradiation at 850 and 450 nm, the device exhibits a positive photoresponse driven by the photoconductive effect, achieving high responsivity of 761.78 A W−1 (0.95 nW) and 694.91 A W−1 (2.125 nW), respectively. Conversely, under irradiation at 1550 and 1310 nm, the device exhibits a negative photoresponse driven by the bolometric effect. The responsivity and response/recovery times under 1550 nm irradiation are measured to be 3.13 A W−1 (578 nW) and 21.3/20.4 ms, respectively. The PD exhibits one of the highest responsivities reported for 2D material‐integrated waveguide PDs. This high‐performance SnSe2/TFLN waveguide PD has broad potential for application in optical communication and multifunctional photonic circuits in the visible to near‐infrared (NIR) band.
Pump‐Induced Terahertz Conductivity Response and Peculiar Bound State in Mn3Si2Te6
Authors: Wu Qiong , Yin Qiangwei , Zhang Sijie , Hu Tianchen , Wu Dong , Yue Li , Li Bohan , Xu Shuxiang , Li Rongsheng , Liu Qiaomei , Lei Hechang , Dong Tao , Wang Nanlin 
Published: November 2023

AbstractThe significant enhancement of ultrafast terahertz optical conductivity and the unexpected formation of a polaronic‐like state in semiconductor Mn3Si2Te6 at room temperature are reported. With the absorption of pump photons, the low‐frequency terahertz photoconductivity spectrum exhibits a significant rise, quickly forming a broad peak and subsequently shifting to higher energy. The short‐lived nature of the broad peak, as well as the distribution of optical constants, strongly points toward a transient polaron mechanism. This study not only provides profound insights into the remarkable photoelectric response of Mn3Si2Te6 but also highlights its significant potential for future photoelectric applications.
Rational Design of AIE Photosensitizers with Full‐Visible Color Emission and Efficient ROS Generation
Authors: Yin Weidong , Ma Yucheng , Chen Shuge , Xing Longjiang , Ji Shaomin , Lam Jacky W. Y. , Kwok Ryan T. K. , Huo Yanping , Tang Ben Zhong 
Published: November 2023

AbstractOrganic photosensitizers (PSs) with aggregation‐induced emission (AIE) characteristics have shown several advantages in photodynamic therapy (PDT). However, how to design PSs with the required optical and biological properties is a formidable challenge. In this work, a series of AIE active pyridine‐ and pyridinium‐functionalized carbazole with different substituents are designed and synthesized. Compared to other analogs, BK‐Pys‐BP containing benzophenone moiety on the pyridinium unit produces reactive oxygen species (ROS) efficiently in the presence of light due to its large spin‐orbit coupling constant to promote efficient intersystem crossing. Based on its structure, three molecules with enhanced donor–acceptor strength and conjugation are further investigated to realize emission covering the whole visible region. The cationic nature and excellent ROS generation ability of benzophenone‐containing AIE photosensitizers allows for specific imaging of mitochondria, killing cancer cells, and as a singlet oxygen donor to catalyze the formation of endoperoxides. Thus, the present work presents an effective strategy for creating AIE photosensitizers with efficient ROS generation for wide biological applications.
“We are not a typical family anymore”: Exploring the experiences and support needs of fathers of children with Fragile X syndrome in Australia
Authors: Luermans Jacintha , Fleming Jane , O'Shea Rosie , Barlow‐Stewart Kristine , Palmer Elizabeth Emma , Leffler Melanie 
Published: November 2023

AbstractA diagnosis of the X‐linked condition Fragile X syndrome (FXS) in a child commonly reveals the mother's carrier status. Previous research focused on the genetic counseling process for the child and maternal family, despite calls for more research on the support needs of fathers. This study explored experiences and support needs of fathers at least 1 year after their child's FXS diagnosis to understand barriers and enablers and optimize health outcomes for the family. In‐depth interviews were conducted with 11 fathers recruited through the Australian Genetics of Learning Disability Service and the Fragile X Association. Deidentified transcripts were analyzed using thematic analysis guided by an inductive approach. Four themes emerged: (1) making life easier through understanding—yesterday and today, (2) the path to a new normal—today and tomorrow, (3) seeking information and support, and (4) what men want. Fathers reported diagnostic odysseys, postdiagnostic grief, and challenges adjusting. They highlighted difficulties in understanding their child's unique behaviors and needs, responding to their partner's psychological support needs, planning for their child's future, and navigating complex health and disability systems. Participants suggested health professionals facilitate father‐to‐father support and psychological counseling. These findings highlight the unmet needs of fathers and suggest that a strengths‐based approach is critically important given the recognized mental health impact.
State‐Independent Geometric Quantum Gates via Nonadiabatic and Noncyclic Evolution
Authors: Chen Yue , Ji Li‐Na , Xue Zheng‐Yuan , Liang Yan 
Published: November 2023

AbstractGeometric phases are robust to local noises and the nonadiabatic ones can reduce the evolution time, thus nonadiabatic geometric gates have strong robustness and can approach high fidelity. However, the advantage of geometric phase has not been fully explored in previous investigations. Here,a scheme is proposed for universal quantum gates with pure nonadiabatic and noncyclic geometric phases from smooth evolution paths. In the scheme, only geometric phase can be accumulated in a fast way, and thus it not only fully utilizes the local noise resistant property of geometric phase but also reduces the difficulty in experimental realization. Numerical results show that the implemented geometric gates have stronger robustness than dynamical gates and the geometric scheme with cyclic path. Furthermore, it proposes to construct universal quantum gate on superconducting circuits, with the fidelities of single‐qubit gate and nontrivial two‐qubit gate can achieve 99.97% and 99.87%, respectively. Therefore, these high‐fidelity quantum gates are promising for large‐scale fault‐tolerant quantum computation.
Konformationeller Austausch eines Liganden in der Bindetasche eines Proteins auf der Mikrosekundenzeitskala
Authors: Kotschy Julia , Söldner Benedikt , Singh Himanshu , Vasa Suresh K. , Linser Rasmus 
Published: November 2023

AbstractDie experimentelle Erfassung möglicher interner Dynamik eines Liganden ohne Isotopenmarkierung im proteingebundenen Zustand ist grundsätzlich schwierig. Hohe Temperaturfaktoren aus Kristallstrukturen können statische Heterogenität nicht von Bewegung unterscheiden, zudem können für symmetrische Bewegungen selbst bei niedrigsten B‐Faktoren schnelle Bewegungen vorhanden sein. Hier zeigen wir die sowohl in Lösung als auch im Kristall experimentell beobachtete interne μs‐Dynamik eines nicht‐isotopenmarkierten Liganden, während dieser mit hoher Affinität an das Enzym humane Carboanhydrase II (hCAII) gebunden ist. Der sprunghafte Wechsel zwischen den Rotameren der Benzolgruppe des Liganden verursacht sowohl in Lösungs‐ als auch Festkörper NMR mit schneller Rotation um den magischen Winkel 1H R1ρ Relaxationsdispersion, für die mittels Molecular Dynamics (MD)‐Simulationen mechanistische Einblicke erhalten werden. Die experimentelle Erfassung von konformationellem Austausch in gebundenen Liganden in Lösung und im Festkörper könnte einem besseren Verständnis von Wirt‐Gast‐Interaktionen in Biologie und supramolekularer und medizinischer Chemie dienen.
Deep‐Ultraviolet Transparent Mixed Metal Sulfamates with Enhanced Nonlinear Optical Properties and Birefringence
Authors: Wang Xuefei , Leng Xudong , Kuk Yunseung , Lee Jihyun , Jing Qun , Ok Kang Min 
Published: November 2023

AbstractEnhancing anisotropy through the controlled arrangement of anionic groups is essential for improving the nonlinear optical (NLO) performance of non‐π‐conjugated NLO materials. In this study, we present the successful synthesis of the first examples of mixed alkali metal‐alkaline earth metal sulfamate materials, including noncentrosymmetric Cs2Mg(NH2SO3)4 ⋅ 4H2O (1), as well as centrosymmetric K2Ca(NH2SO3)4 (2) and Rb2Ca(NH2SO3)4 (3). All three compounds feature promising deep ultraviolet cut‐off edges, notably 1 with a cut‐off edge below 180 nm. The synergy of Cs+ and Mg2+ cations in 1 facilitated the successful alignment of polar [NH2SO3] tetrahedra in a uniform orientation. Remarkably, 1 stands as the sole instance among reported sulfamate compounds with a co‐parallel anionic arrangement, yielding a very large dipole moment compared to other non‐π‐conjugated NLO materials. Moreover, the substantial dipole moment of 1 yields an enhanced second harmonic generation response, approximately 2.3 times that of KH2PO4, and a large birefringence of 0.054 at 546.1 nm. The approach of regulating the arrangement of anionic groups using aliovalent cations holds promise for advancing the exploration of non‐π‐conjugated NLO materials.
Accelerated Electrophotocatalytic C(sp3)−H Heteroarylation Enabled by an Efficient Continuous‐Flow Reactor**
Authors: Ioannou Dimitris I. , Capaldo Luca , Sanramat Jiri , Reek Joost N. H. , Noël Timothy 
Published: November 2023

AbstractElectrophotocatalytic transformations are garnering attention in organic synthesis, particularly for accessing reactive intermediates under mild conditions. Moving these methodologies to continuous‐flow systems, or flow ElectroPhotoCatalysis (f‐EPC), showcases potential for scalable processes due to enhanced irradiation, increased electrode surface, and improved mixing of the reaction mixture. Traditional methods sequentially link photochemical and electrochemical reactions, using flow reactors connected in series, yet struggle to accommodate reactive transient species. In this study, we introduce a new flow reactor concept for electrophotocatalysis (EPC) that simultaneously utilizes photons and electrons. The reactor is designed with a transparent electrode and employs cost‐effective materials. We used this technology to develop an efficient process for electrophotocatalytic heteroarylation of C(sp3)−H bonds. Importantly, the same setup can also facilitate purely electrochemical and photochemical transformations. This reactor represents a significant advancement in electrophotocatalysis, providing a framework for its application in flow for complex synthetic transformations.
Umpolung Isomerization in Radical Copolymerization of Benzyl Vinyl Ether with Pentafluorophenylacrylate Leading to Degradable AAB Periodic Copolymers
Authors: Kuroda Keita , Ouchi Makoto 
Published: November 2023

AbstractThis study revealed that benzyl vinyl ether (BnVE) shows a peculiar isomerization propagation in its radical copolymerization with an electron‐deficient acrylate carrying a pentafluorophenyl group (PFA). The co‐monomer pair inherently exhibits the cross‐over propagation feature due to the large difference in the electron density. However, the radical species of PFA was found to undergo a backward isomerization to the penultimate BnVE pendant giving a benzyl radical species prior to propagation with BnVE. The isomerization brings a drastic change in the character of the growing radical species from electrophilic to nucleophilic, and thus the isomerized benzyl radial species propagates with PFA. Consequently, the two monomers were consumed in the order AAB (A: PFA; B: BnVE) and the unique periodic consumption was confirmed by the pseudo‐reactivity ratios calculated by the penultimate model: r11=0.174 and r21=6600 for PFA (M1) with BnVE (M2). The pentafluorophenyl ester groups of the resulting copolymers are transformed into ester and amide groups by post‐polymerization alcoholysis and aminolysis modifications. The unique isomerization in the AAB sequence allowed the periodic introduction of a benzyl ether structure in the backbone leading to efficient degradation under acid conditions.
Immunolocalization of the mechanogated ion channels PIEZO1 and PIEZO2 in human and mouse dental pulp and periodontal ligament
Authors: Gaite Juan J. , Solé‐Magdalena Antonio , García‐Mesa Yolanda , Cuendias Patricia , Martin‐Cruces José , García‐Suárez Olivia , Cobo Teresa , Vega José A. , Martín‐Biedma Benjamín 
Published: November 2023

AbstractPIEZO1 and PIEZO2 are essential components of mechanogated ion channels, which are required for mechanotransduction and biological processes associated with mechanical stimuli. There is evidence for the presence of PIEZO1 and PIEZO2 in teeth and periodontal ligaments, especially in cell lines and mice, but human studies are almost nonexistent. Decalcified permanent human teeth and mouse molars were processed for immunohistochemical detection of PIEZO1 and PIEZO2. Confocal laser microscopy was used to examine the co‐localization of PIEZO 1 and PIEZO2 with vimentin (a marker of differentiated odontoblasts) in human teeth. In the outer layer of the human dental pulp, abundant PIEZO1‐ and PIEZO2‐positive cells were found that had no odontoblast morphology and were vimentin‐negative. Based on their morphology, location, and the absence of vimentin positivity, they were identified as dental pulp stem cells or pre‐odontoblasts. However, in mice, PIEZO1 and PIEZO2 were ubiquitously detected and colocalized in odontoblasts. Intense immunoreactivity of PIEZO1 and PIEZO2 has been observed in human and murine periodontal ligaments. Our findings suggest that PIEZO1 and PIEZO2 may be mechanosensors/mechanotransducers in murine odontoblasts, as well as in the transmission of forces by the periodontal ligament in humans and mice.
Control of a class of discrete event systems with disturbances and capacity constraints: Application to a disassembly problem
Authors: Syrine Bouazza , Said Amari , Hichem Hassine 
Published: November 2023

AbstractThis study proposes an analytical control method for the meeting of capacity constraints in discrete event systems with disturbances. More precisely, it consists of computing control laws for partially controllable and observable timed event graphs that are subject to marking constraints. To resolve the issue, linear Min‐Plus models are used to describe the behavior of these graphs, and the constraints are expressed by inequalities in Min‐Plus algebra. Sufficient conditions for the existence of causal control laws to guarantee marking specifications are established. Finally, to illustrate the efficiency of the proposed approaches in this paper, an application for a disassembly process with some disturbance inputs and limited component capacities is carried out.
Optimierungsgestützte Platzierung individueller Hohlkörper in Platten
Authors: Clauß Felix , Forman Patrick , Rose Jannis , Kühl Magdalena , Mark Peter 
Published: November 2023

AbstractMaterialeinsparungen sind im Bauwesen unerlässlich. Ohne sie lassen sich die weltweit gesteckten Klimaziele nicht erreichen. Bei Betonplatten sind Hohlkörper eine Möglichkeit dazu. Sie verdrängen bis etwa 35 % an Betonvolumen, und zwar in Bereichen geringer Querkraft‐ und Biegebeanspruchung. Dabei wird bislang nur je eine Hohlkörperform eingesetzt. Im Beitrag wird ein Verfahren hergeleitet, das gegenüber den bisherigen Berechnungskonzepten zwei wesentliche Verbesserungen liefert. Zum einen sind beliebige Hohlkörperformen und ‐größen das Ergebnis, sodass innerhalb einer Platte je nach Tragfähigkeitsreserve verschieden große Hohlkörper nutzbar sind. Die Formen können beliebig rechteckig, kugelförmig oder ellipsoid ausfallen und werden generalisiert über sogenannte Superellipsoide beschrieben. Zum anderen ist die Optimierung an die Schnittgrößenermittlung der Platte gekoppelt, sodass die Veränderung der Schnittgrößenverteilung aus der Steifigkeitsbeeinflussung durch die Hohlkörper direkt ins Verfahren mit eingeht. Nachlaufende Kontrollen von Schnittgrößenumlagerungen entfallen. Kern des Optimierungsverfahrens ist die rechnerische Variation der Dichte, die mit dem verbliebenen Betonmaterial gleichgesetzt wird. Die Tragfähigkeit wird durch minimal einzuhaltende Druckzonenhöhen (Biegung) und reduzierte Widerstände schubunbewehrter Platten (Querkraft) nachgewiesen. Zwei Beispiele zeigen die praktische Anwendung an Plattenstreifen bzw. Flachdecken.
Transcatheter correction of sinus venosus defect in a patient with a challenging anatomical configuration: From bench testing to clinical success
Authors: Batteux Clement , Ciobotaru Vlad , Arditi William , Decante Benoit , Karsenty Clement , Combes Nicolas , Hascoet Sebastien 
Published: November 2023

AbstractWe report successful transcatheter correction of a sinus venosus defect in a 72‐year‐old woman with anomalous pulmonary venous return in a challenging anatomical configuration. The procedure was facilitated by hands‐on simulation training on a newly developed, perfused, 3D‐printed model.
Can Nitazoxanide and/or other anti‐viral medications be a solution to long COVID? Case report with a brief literature review
Authors: Stewart Denise D. 
Published: November 2023

Key Clinical MessageFindings here imply lingering of virus, SARS‐CoV‐2, in the body for months. Thus, Nitazoxanide and/or other anti‐viral medications might be potential options to combat long COVID. This could transform treatment for long COVID patients globally.AbstractLong COVID or post‐acute sequelae of COVID‐19 (PASC) continues to affect many people even after a relatively mild acute illness. Underlying causes of PASC are poorly understood. There is no particular treatment or management program developed yet. Thus, the possibility of well‐known, safe anti‐viral medications use against PASC is proposed here.
Congenital mastoid‐isolated cholesteatoma in a 14‐year‐old boy
Authors: McKenna Dominic , Reddy Ekambar 
Published: November 2023

Key Clinical MessageCongenital mastoid confined cholesteatoma is a very rare entity with only 30 reported cases worldwide. We describe the presentation and treatment of this condition in a 14‐year‐old boy, with maintenance of normal hearing and ear canal function.
Nonoperative management of biliopleural fistula following living‐donor liver transplantation: A case report
Authors: Kazemi Kourosh , Rasekhi Alireza , Nazari Sahar Sohrabi , Lashkarizadeh Mohammad Mehdi , Shamsaeefar Alireza , Alikhani Mohammad , Akbari Ali , Shahriarirad Reza 
Published: November 2023

Key Clinical MessageBiliopleural fistula is a rare but serious complication after liver transplantation that should be managed nonoperatively with antibiotics, pleural drainage, decompression of high‐pressure biliary tract, or ultimately surgery in unresponsive cases.AbstractBilious pleural effusion is a rare entity often iatrogenic, following hepatobiliary surgeries and biliary interventions, and has been reported only in a limited number of patients after liver transplantation. A 5‐year‐old girl underwent living donor liver transplantation due to progressive familial intrahepatic cholestasis. At the 7th day of the postoperative course, due to increased liver enzymes and bilirubin levels and intrahepatic bile duct dilatation on sonography, Magnetic Resonance Cholangiopancreaticography followed by a liver biopsy were performed; the findings demonstrated moderate intrahepatic bile duct dilatation and moderate cellular rejection associated with mild cholestasis, respectively. The patient was therefore administered a pulse of methylprednisolone; however, due to fever, peritonitis and also sonographic evidence of infected biloma collection adjacent to the transplanted liver, the patient underwent surgery. Laparotomy and peritoneal washout were performed and a Jackson‐Pratt drain was inserted adjacent to the liver cut surface. Succeeding tachypnea on 28th post day, led to detection of right side massive pleural effusion on chest Xray and hence thoracostomy tube was inserted. A diagnosis of biliopleural fistula was established and broad‐spectrum intravenous antibiotic therapy was started, followed by cholangiography, fistula closure, and bile duct stricture ballooning and internal‐external biliary catheter insertion. The patient was discharged in generally good condition on the 50th posttransplant day. The diagnosis of biliopleural fistula is facilitated with the utilization of chest imaging and pleural fluid analysis, however, a high index of suspicion is required.