bluuebunny/crossref_metadata_2025_split huggingface dataset:
Data‐independent acquisition proteomics of cerebrospinal fluid implicates endoplasmic reticulum and inflammatory mechanisms in amyotrophic lateral sclerosis
Authors: Dellar Elizabeth R. , Vendrell Iolanda , Talbot Kevin , Kessler Benedikt M. , Fischer Roman , Turner Martin R. , Thompson Alexander G. 
Published: December 2023

AbstractWhile unbiased proteomics of human cerebrospinal fluid (CSF) has been used successfully to identify biomarkers of amyotrophic lateral sclerosis (ALS), high‐abundance proteins mask the presence of lower abundance proteins that may have diagnostic and prognostic value. However, developments in mass spectrometry (MS) proteomic data acquisition methods offer improved protein depth. In this study, MS with library‐free data‐independent acquisition (DIA) was used to compare the CSF proteome of people with ALS (n = 40), healthy (n = 15) and disease (n = 8) controls. Quantified protein groups were subsequently correlated with clinical variables. Univariate analysis identified 7 proteins, all significantly upregulated in ALS versus healthy controls, and 9 with altered abundance in ALS versus disease controls (FDR < 0.1). Elevated chitotriosidase‐1 (CHIT1) was common to both comparisons and was proportional to ALS disability progression rate (Pearson r = 0.41, FDR‐adjusted p = 0.035) but not overall survival. Ubiquitin carboxyl‐terminal hydrolase isozyme L1 (UCHL1; upregulated in ALS versus healthy controls) was proportional to disability progression rate (Pearson r = 0.53, FDR‐adjusted p = 0.003) and survival (Kaplan Meier log‐rank p = 0.013) but not independently in multivariate proportional hazards models. Weighted correlation network analysis was used to identify functionally relevant modules of proteins. One module, enriched for inflammatory functions, was associated with age at symptom onset (Pearson r = 0.58, FDR‐adjusted p = 0.005) and survival (Hazard Ratio = 1.78, FDR = 0.065), and a second module, enriched for endoplasmic reticulum proteins, was negatively correlated with disability progression rate (r = −0.42, FDR‐adjusted p = 0.109). DIA acquisition methodology therefore strengthened the biomarker candidacy of CHIT1 and UCHL1 in ALS, while additionally highlighted inflammatory and endoplasmic reticulum proteins as novel sources of prognostic biomarkers.
Mental health and jaw function of patients with anterior disc displacement with reduction
Authors: Yao Yuan , Liu Sha Sha , Jin Lei , Zeng Hong , Jiang Xin , Fang Zhong Yi , Cai Bin , Xu Lili 
Published: December 2023

AbstractBackgroundThe mental health of patients with temporomandibular disorder or other jaw dysfunction is a primary concern in clinical practice, but the extent of these symptoms in this patient subset is not yet well understood.ObjectivesThis cross‐sectional study aimed to compare the mental health and jaw function between patients with anterior disc displacement with reduction (ADDWR) and healthy individuals.MethodsIn total, 170 patients with ADDWR and 163 healthy participants enrolled in this study from March 2020 to December 2021. All participants completed a single assessment, including a pain rating and several questionnaires to assess jaw dysfunction, depression, and anxiety. All scores and the grade distribution of somatization, depression and anxiety were analysed between groups.ResultsSignificant differences were found in measures of pain, jaw function and somatization; the ADDWR group had significantly higher pain and functional jaw limitations than the healthy group. The grade distribution of somatic symptoms also differed between groups: the distribution of patients who reported mild and above scores in the ADDWR group was significantly higher than that of the healthy group. Depression and anxiety scores or grade distributions were not significantly different by group.ConclusionThe jaw function of patients seeking treatment for ADDWR was lower than that of non‐TMD individuals. They did not show high anxiety and depression symptoms, but their somatic symptoms were more apparent.
Coping strategies in response to peer victimization: Comparing adolescents in the United States and Korea
Authors: Yang Joo Young , McDonald Kristina L. , Seo Sunmi 
Published: December 2023

AbstractWe examined cultural specificity in how adolescents' coping strategies in response to peer victimization are associated with adjustment with a sample of 7th–8th graders from the United States (n = 292, 60% female, Mage = 13.6, SD = 0.65) and South Korea (n = 462, 50.2% female, Mage = 13.7, SD = 0.58). Participants read scenarios describing victimization and rated the likelihood of utilizing different coping strategies. US adolescents rated conflict resolution, cognitive distancing, and revenge higher than Korean adolescents, while Korean adolescents endorsed social support seeking more than US adolescents. Social support seeking was positively associated with global self‐worth in both countries; however, social support seeking was negatively related to depression and social anxiety only for Korean youth.
The Precarious Spaces Between Us: The Exchange of Food and Merit in Thailand's Affective Moral Economy during the COVID‐19 Pandemic
Authors: Cassaniti Julia 
Published: December 2023

ABSTRACTIn the middle of 2020, Buddhism in Thailand looked quite different than it had just prior to the COVID‐19 pandemic. Monasteries had closed their doors to the public, and monastic ordinations ceased. The institution of Thai Buddhism stayed relevant, however, largely by promoting a quite unusual practice. In addition to the typical religious activity of lay followers offering food to monks, and receiving merit from the monks in return, the path that food traveled during the pandemic also turned the other way around. In a curious series of events, monks at monasteries throughout the country began to hand out food to lay Buddhist followers. In a religious landscape with a very codified system of exchange, this was spiritually precarious: if monks give out food, where does the merit lie, and what are the karmic results? To answer this, I examine attitudes about monks’ activities, drawing on interviews conducted in Chiang Mai in 2021, and relationships to textual accounts of nutrients and healing across Buddhist history. Rather than signifying a break from spiritual relationships, I argue that this a‐typical movement during the pandemic helps to highlight the continuing importance of monastic hope within interpersonal affective economies of Thai Buddhist practice.
Excess deaths associated with COVID‐19 by rurality and demographic factors in the United States
Authors: Ahrens Katherine A. , Rossen Lauren M. , Milkowski Carly , Gelsinger Catherine , Ziller Erika 
Published: December 2023

AbstractPurposeTo estimate percent excess deaths during the COVID‐19 pandemic by rural‐urban residence in the United States and to describe rural‐urban disparities by age, sex, and race/ethnicity.MethodsUsing US mortality data, we used overdispersed Poisson regression models to estimate monthly expected death counts by rurality of residence, age group, sex, and race/ethnicity, and compared expected death counts with observed deaths. We then summarized excess deaths over 6 6‐month time periods.FindingsThere were 16.9% (95% confidence interval [CI]: 16.8, 17.0) more deaths than expected between March 2020 and February 2023. The percent excess varied by rurality (large central metro: 18.2% [18.1, 18.4], large fringe metro: 15.6% [15.5, 15.8], medium metro: 18.1% [18.0, 18.3], small metro: 15.5% [15.3, 15.7], micropolitan rural: 16.3% [16.1, 16.5], and noncore rural: 15.8% [15.6, 16.1]). The percent excess deaths were 20.2% (20.1, 20.3) for males and 13.6% (13.5, 13.7) for females, and highest for Hispanic persons (49% [49.0, 49.6]), followed by non‐Hispanic Black persons (28% [27.5, 27.9]) and non‐Hispanic White persons (12% [11.6, 11.8]). The 6‐month time periods with the highest percent excess deaths for large central metro areas were March 2020‐August 2020 and September 2020‐February 2021; for all other areas, these time periods were September 2020‐February 2021 and September 2021‐February 2022.ConclusionPercent excess deaths varied by rurality, age group, sex, race/ethnicity, and time period. Monitoring excess deaths by rurality may be useful in assessing the impact of the pandemic over time, as rural‐urban patterns appear to differ.
Surgical treatment of canine urethral prolapse via urethropexy or resection and anastomosis
Authors: Healy D. , Rizkallal C. , Rossanese M. , McLarnon P. , Vallefuoco R. , Murgia D. , Ryan T. , Howes C. , Anderson O. , Charlesworth T. , Cinti F. , Martin S. , Das S. , Cantatore M. 
Published: December 2023

ObjectivesThe objective was to report and compare the complications and recurrence rates of urethral prolapse in dogs when treated with urethropexy, resection and anastomosis or a combined surgical technique. Study design: Retrospective study.Materials and MethodsA total of 86 dogs were identified from the medical records of 10 veterinary referral hospitals from February 2012 and October 2022. Dogs were included if they underwent surgery for a urethral prolapse at first presentation. Complications were classified as minor or major based on the necessity of further surgical intervention. Complications leading to death were also considered major complications.ResultsSeventy‐nine dogs were included, urethropexy (n=44), resection and anastomosis (n=27) and a combined surgical technique (n=8). Minor complications were identified in 41 of 79 dogs (51.9%): urethropexy 19 of 44 (43.2%), resection and anastomosis 18 of 27 (66.6%) and a combined surgical technique four of eight (50%). Major complications occurred in 23 dogs (29.1%), of which 21 were recurrence (26.6%). Recurrence occurred in 17 of 44 dogs following a urethropexy (38.6%), three of 27 dogs following resection and anastomosis (11.1%) and one of eight dogs treated with a combined surgical technique (12.5%). Recurrence of a urethral prolapse was significantly more likely following urethropexy in comparison to resection and anastomosis.Clinical SignificanceResection and anastomosis was associated with a lower recurrence rate in comparison to urethropexy for the surgical treatment of urethral prolapse. Based on these results, we concluded that resection and anastomosis may be preferable to urethropexy for treatment of urethral prolapse at first presentation. Urethropexy, and resection and anastomosis combined surgical technique was associated with low recurrence rate; however, further studies will be needed to clarify if it provides any benefit over resection and anastomosis.
Long‐term safety of dietary salt: A 5‐year ProspEctive rAndomized bliNded and controlled stUdy in healThy aged cats (PEANUT study)
Authors: Reynolds Brice S. , Chetboul Valerie , Elliott Jonathan , Laxalde Jeremy , Nguyen Patrick , Testault Isabelle , Dorso Laëticia , Abadie Jérôme , Lefebvre Hervé P. , Biourge Vincent 
Published: December 2023

AbstractBackgroundHigh‐salt diets promote urine dilution and decrease urolithiasis risk.ObjectiveProspectively evaluate the safety of chronic high dietary salt intake (randomized controlled trial).AnimalsTwenty research colony neutered, healthy aged cats (11.5 years [10.0‐11.6], median [interquartile range]).MethodsHealthy cats were randomized to control or high‐salt dry diets (sodium: 1.02 ± 0.16 [mean, SD] and 3.26 ± 0.30 g/Mcal metabolizable energy [ME], respectively; chloride: 2.26 ± 0.33 and 5.71 ± 0.28 g/Mcal ME, respectively), fed for up to 60 months. Assessments included CBC, plasma biochemistry, urinalysis, glomerular filtration rate (GFR), blood pressure, renal and cardiac (conventional Doppler and 2‐dimensional color tissue Doppler) imaging, annually. Cats that died or were euthanized underwent necropsy. Diet effects over time were evaluated with linear mixed models.ResultsFollow‐up duration (median [Interquartile range]) was similar between the control (38.7 months [28.6‐48.2]) and high‐salt group (51.4 months [45.7‐59.0]). Diet had no significant effect on changes in GFR, blood pressure, plasma creatinine concentration, end‐diastolic left ventricular (LV) wall thicknesses, LV internal diameters, LV systolic function, left atrial size, or systolic and diastolic Doppler variables. One control cat developed hypertension. One high‐salt group cat developed persistent azotemia. Serial plasma biochemistry and urine specific gravity suggested early chronic kidney disease in 4 nonazotemic cats (2 per group), consistent with necropsy findings.Conclusions and Clinical ImportanceIn healthy aged cats, a commercial veterinary diet containing 3.26 ± 0.30 g/Mcal ME sodium was safe with regard to renal and cardiac function for up to 5 years.
A realist synthesis of prospective entrustment decision making by entrustment or clinical competency committees
Authors: Schumacher Daniel J. , Michelson Catherine , Winn Ariel S. , Turner David A. , Martini Abigail , Kinnear Benjamin 
Published: December 2023

AbstractIntroductionThe real‐world mechanisms underlying prospective entrustment decision making (PEDM) by entrustment or clinical competency committees (E/CCCs) are poorly understood. To advance understanding in this area, the authors conducted a realist synthesis of the published literature to address the following research question: In E/CCC efforts to make defensible prospective entrustment decisions (PEDs), what works, for whom, under what circumstances and why?MethodsRealist work seeks to understand the contexts (C), mechanisms (M) and outcomes (O) that explain how and why things work (or do not). In the authors' study, contexts included individual E/CCC members, E/CCC structures and processes, and training programmes. The outcome (i.e. desired outcome) was a PED. Mechanisms were a substantial focus of the analysis and informed the core findings. To define a final corpus of 52 included papers, the authors searched four databases, screened all results from those searches and performed a full‐text review of a subset of screened papers. Data extraction focused on developing context–mechanism–outcome configurations from the papers, which were used to create a theory for how PEDM leads to PEDs.ResultsPEDM is often driven by default (non‐deliberate) decision making rather than a deliberate process of deciding whether a trainee should be entrusted or not. When defaulting, some E/CCCs find red flags that sometimes lead to being more deliberate with decision making. E/CCCs that seek to be deliberate describe PEDM that can be effortful (when data are insufficient or incongruent) or effortless (when data are robust and tell a congruent story about a trainee). Both information about trainee trustworthiness and the sufficiency of data about trainee performance influence PEDM. Several moderators influence what is considered to be sufficient data, how trustworthiness data are viewed and how PEDM is carried out. These include perceived consequences and associated risks, E/CCC member trust propensity, E/CCC member personal knowledge of and experience with trainees and E/CCC structures and processes.DiscussionPEDM is rarely deliberate but should be. Data about trainee trustworthiness are foundational to making PEDs. Bias, equity and fairness are nearly absent from the papers in this synthesis, and future efforts must seek to advance understanding and practice regarding the roles of bias, equity and fairness in PEDM.
Tracing the serendipitous genesis of radiation resistance
Authors: Ujaoney Aman Kumar , Anaganti Narasimha , Padwal Mahesh Kumar , Basu Bhakti 
Published: December 2023

AbstractFree‐living organisms frequently encounter unfavorable abiotic environmental factors. Those who adapt and cope with sudden changes in the external environment survive. Desiccation is one of the most common and frequently encountered stresses in nature. On the contrary, ionizing radiations are limited to high local concentrations of naturally occurring radioactive materials and related anthropogenic activities. Yet, resistance to high doses of ionizing radiation is evident across the tree of life. The evolution of desiccation resistance has been linked to the evolution of ionizing radiation resistance, although, evidence to support the idea that the evolution of desiccation tolerance is a necessary precursor to ionizing radiation resistance is lacking. Moreover, the presence of radioresistance in hyperthermophiles suggests multiple paths lead to radiation resistance. In this minireview, we focus on the molecular aspects of damage dynamics and damage response pathways comprising protective and restorative functions with a definitive survival advantage, to explore the serendipitous genesis of ionizing radiation resistance.
Transformation of PMMA from sunlight‐blocking to sunlight‐activated coupled with DNH photocatalytic platform for oxidative coupling of amines and generation/regeneration of LDC/NADH
Authors: Singh Satyam , Yadav Rajesh K. , Umar Ahmad , Ibrahim Ahmed A. , Kim Tae Wu , Singh Atul Pratap , Kumar Rajesh , Chaudhary Sandeep , Dwivedi Dilip K. , Singh Ravindra Vikram , Gupta Navneet Kumar , Singh Chandani , Baeg Jin‐O. , Baskoutas Sotirios 
Published: December 2023

AbstractThe photocatalytic oxidation and generation/regeneration of amines to imines and leucodopaminechrome (LDC)/NADH are subjects of intense interest in contemporary research. Imines serve as crucial intermediates for the synthesis of solar fuels, fine chemicals, agricultural chemicals, and pharmaceuticals. While significant progress has been made in developing efficient processes for the oxidation and generation/regeneration of secondary amines, the oxidation of primary amines has received comparatively less attention until recently. This discrepancy can be attributed to the high reactivity of imines generated from primary amines, which are prone to dehydrogenation into nitriles. In this study, we present the synthesis and characterization of a novel polymer‐based photocatalyst, denoted as PMMA‐DNH, designed for solar light‐harvesting applications. PMMA‐DNH incorporates the light‐harvesting molecule dinitrophenyl hydrazine (DNH) at varying concentrations (5%, 10%, 20%, 30%, and 40%). Leveraging its high molar extinction coefficient and slow charge recombination, the 30% DNH‐incorporated PMMA photocatalyst proves to be particularly efficient. This photocatalytic system demonstrates exceptional yields (96.5%) in imine production and high generation/regeneration rates for LDC/NADH (65.27%/78.77%). The research presented herein emphasizes the development and application of a newly engineered polymer‐based photocatalyst, which holds significant promise for direct solar‐assisted chemical synthesis in diverse commercial applications.
Pediatric parenteral nutrition and hydroperoxide toxicity: Evaluation of the effectiveness of photoprotection medical devices
Authors: Nizet Pierre , Guillard Nicolas , Chabaud Lionel , Sellal Kamel‐Olivier , Lejus‐Bourdeau Corinne , Simon Laure , Navas Dominique , Olivier Emmanuelle , Clouet Johann , Lindenberg Fabien , Nativel Fabien 
Published: December 2023

AbstractExposure of parenteral nutrition (PN) to light induces hydroperoxide (HPO) formation whose toxicity, especially in pediatrics, is documented. In this context, we evaluated the efficacy of photoprotection medical devices used in our institution to protect PN from degradation after two different exposures to light. A mixed oil lipid emulsion (Smoflipid®) in standard or opaque syringes and a ternary PN mixture bags (Numetah®) with or without opaque overwrap were exposed for at least 420 min to a xenon lamp. Samples of Smoflipid® in standard or opaque syringes were also exposed for 24 h to conditions reproducing those of a neonatal intensive care unit. The use of opaque syringes for Smoflipid® administration or opaque overwraps for Numetah® administration reduced HPO formation by an average of 14% and 40%, respectively, compared to standard conditions after at least 420 min to a xenon lamp. When Smoflipid® samples were administered with standard or opaque syringes and exposed to a phototherapy lamp, the fold‐change in the HPO concentration increased, respectively, by 6.3 or 5.4 at 24 h compared with syringes unexposed to phototherapy lamp. Although the observed differences were non‐significant, it nonetheless appears prudent to use photoprotection of PN during administration, particularly in patients with immature or compromised antioxidant capacity.
Xanthomonas species causing leaf blight on eucalypt plants in Brazil and transfer of Xanthomonas axonopodis pv. eucalyptorum to Xanthomonas citri pv. eucalyptorum comb. nov.
Authors: Ferraz Hélvio Gledson Maciel , Badel Jorge Luis , Neves Yane Fernandes , Eloi Ana Carolina Lopes , Vidigal Pedro Marcus Pereira , Guimarães Lúcio Mauro da Silva , Alfenas Acelino Couto 
Published: December 2023

AbstractOutbreaks of bacterial leaf blight (BLB) frequently affect eucalypt plants under nursery and field conditions in several countries. Although research has been conducted to unveil the causal agent, different bacterial species have been associated with similar disease symptoms in different countries. In order to determine the causal agent of BLB in Brazil, a survey was conducted in nine states to recover bacterial isolates from eucalypt plants exhibiting typical BLB symptoms. A total of 41 yellow‐colony isolates with varying aggressiveness towards a susceptible eucalypt clone were obtained, with 16S rDNA sequences indicating that they belong to the Xanthomonas genus. Rep‐PCR analysis separated the Xanthomonas population affecting eucalypt into six distinct groups revealing its high genetic diversity. The same population formed three clusters together with reference strains of X. citri, X. euvesicatoria and X. phaseoli in a phylogenetic tree constructed with partial dnaK, fyuA, gyrB and rpoD gene sequences. Clustering in the phylogenetic tree was clearly related to grouping based on rep‐PCR. Genome sequence comparisons of representative eucalypt isolates with type strains of validly published Xanthomonas species confirmed that the population consisted of X. citri, X. euvesicatoria and X. phaseoli. Inoculation of tomato, common bean, castor bean and eucalypt plants showed that the representative eucalypt isolates can cause disease in these plant species. Based on the results, the transfer of Xanthomonas axonopodis pv. eucalyptorum to Xanthomonas citri is proposed. These results are relevant for eucalypt BLB management under nursery and field conditions, including selection and deployment of effective plant resistance.