bluuebunny/crossref_metadata_2025_split huggingface dataset:
Automated Deep Learning Model with Optimization Mechanism for Segmenting Leukemia from Blood Smear Images
Authors: Rai Anjani Kumar , Ganeshan P. , Almoallim Hesham S. , Alharbi Sulaiman Ali , Raghavan S. S. 
Published: September 2023

The advancement of digital microscopic scanning has made the study of image processing as well as categorization an exciting field of diagnostic studies. The literature describes a number of methods for detecting acute lymphocytic leukemia (ALL) using blood smear pictures. The goal of this research is to create an efficient approach for segmenting and detecting leukemia. This research has created a leukemia diagnosis module predicated on deep learning (DL) using blood smear pictures. Pre-processing, segmentation, extraction of features, and classification are performed here by the identification scheme. The presented hybrid model of African Buffalo and African Vulture Optimization (AB-AVO) performs the segmentation process, in which cytoplasm and nucleus regions are segmented. The Local Directional Pattern (LDP) and color histogram characteristics have been then retrieved from the segmented pictures and given into the presented Recurrent Neural Network (RNN) for categorization. The ALL-IDB1 and ALL-IDB2 databases’ blood smear pictures are taken into account for the investigation and assessed using metrics including F1-score, sensitivity, dice coefficient, precision, specificity, recall, and accuracy. The presented AB-AVO-RNN approach exhibits 100% accuracy, according to simulation data. Modern methodologies are used to compare the effectiveness of the suggested AB-AVO-RNN methodology. The investigation demonstrates that the suggested classifier performs comparably better and can identify leukemia from blood smear pictures.
Prevalence and Associated Factors of Adolescent Obesity among Rural School Adolescents in Nepal: A Cross-Sectional Study
Authors: Sitaula Deekshanta , Dhakal Aarati , Lageju Nimesh , Silwal Amisha , Basnet Samjhana Kshetri , Shrestha Niki , Anup Bikram B. C. , Phoju Niraj 
Published: September 2023

Background. Overweight and obesity are major risk factors for chronic diseases and are the leading cause of mortality worldwide. Obesity during adolescence is strongly associated with adulthood obesity leading to increased morbidities and mortality. As a developing country undergoing rapid urbanization, Nepal is in a transitional phase where undernutrition coexists with obesity; however, there is a dearth of literature on the status of adolescent obesity in the rural section of Nepal. The aim of this study was to determine the prevalence of adolescent obesity in a rural district of Nepal and find out its associated factors. Methods. An institution-based cross-sectional study was conducted among the adolescent students studying in classes 8, 9, and 10 in four secondary schools of Gosaikunda rural municipality of Rasuwa district, Nepal. Total enumerative sampling was used, and Global School-based Health Survey (GSHS) standard questionnaires were used in collecting the information. Height and weight measurements were taken, and the body mass index was classified according to Asia-Pacific criteria. The collected data were analyzed using “SPSS” version 22. Logistic regression analysis was used to evaluate the associated factors, and a

p

value of ≤0.05 was considered statistically significant. Results. Out of 267 adolescents, 14.6% were obese and 14.6% were overweight. Of the female participants, 39.6% were either obese or overweight, while 12.6% of the male adolescents were overweight/obese. Among the total participants, 16.5% were underweight, including 14.0% females and 20.4% males. Female adolescents were about five times (AOR: 5.2, 95% CI (2.5–10.9),

p

< 0.01) more likely of being overweight/obese than male adolescents. Conclusions. More than one-quarter of the adolescents were found to be obese/overweight, and the prevalence was significantly more among female adolescents. It emphasizes the necessity of school-based programs promoting a healthy lifestyle among students to maintain healthy weight status.
Brentuximab Vedotin–Driven Microtubule Disruption Results in Endoplasmic Reticulum Stress Leading to Immunogenic Cell Death and Antitumor Immunity
Authors: Heiser Ryan A. , Cao Anthony T. , Zeng Weiping , Ulrich Michelle , Younan Patrick , Anderson Martha E. , Trueblood Esther S. , Jonas Mechthild , Thurman Robert , Law Che-Leung , Gardai Shyra J. 
Published: September 2023

Abstract
Brentuximab vedotin, a CD30-directed antibody–drug conjugate (ADC), is approved for clinical use in multiple CD30-expressing lymphomas. The cytotoxic payload component of brentuximab vedotin is monomethyl auristatin E (MMAE), a highly potent microtubule-disrupting agent. Preclinical results provided here demonstrate that treatment of cancer cells with brentuximab vedotin or free MMAE leads to a catastrophic disruption of the microtubule network eliciting a robust endoplasmic reticulum (ER) stress response that culminates in the induction of the classic hallmarks of immunogenic cell death (ICD). In accordance with the induction of ICD, brentuximab vedotin–killed lymphoma cells drove innate immune cell activation in vitro and in vivo. In the “gold-standard” test of ICD, vaccination of mice with brentuximab vedotin or free MMAE-killed tumor cells protected animals from tumor rechallenge; in addition, T cells transferred from previously vaccinated animals slowed tumor growth in immunodeficient mice. Immunity acquired from killed tumor cell vaccination was further amplified by the addition of PD-1 blockade. In a humanized model of CD30+ B-cell tumors, treatment with brentuximab vedotin drove the expansion and recruitment of autologous Epstein-Barr virus–reactive CD8+ T cells potentiating the activity of anti–PD-1 therapy. Together, these data support the ability of brentuximab vedotin and MMAE to drive ICD in tumor cells resulting in the activation of antigen-presenting cells and augmented T-cell immunity. These data provide a strong rationale for the clinical combination of brentuximab vedotin and other MMAE-based ADCs with checkpoint inhibitors.
Associations of Sleep Patterns With Dynamic Trajectory of Cardiovascular Multimorbidity and Mortality: A Multistate Analysis of a Large Cohort
Authors: Zhang Jingyi , Chen Lan , Zhang Shiyu , Cai Miao , Zou Hongtao , Vaughn Michael G. , Tabet Maya , Qian Zhengmin (Min) , Lin Hualiang 
Published: September 2023

Background
The purpose of this study was to explore the association of sleep patterns with the development of first cardiovascular diseases (FCVD), progression to cardiovascular multimorbidity (CVM), and subsequently to mortality.

Methods and Results
This prospective study included 381 179 participants without coronary heart disease, stroke, atrial fibrillation, or heart failure at baseline, and they were followed up until March 31, 2021. We generated sleep patterns by summing the scores for 5 sleep behaviors, whereby <7 or >8 hours/d of sleep, evening chronotype, frequent insomnia, snoring, and daytime dozing were defined as high‐risk groups. We used a multistate model to estimate the impacts of sleep patterns on the dynamic progression of cardiovascular diseases. Over a median follow‐up of 12.1 years, 41 910 participants developed FCVD, 7302 further developed CVM, and 20 707 died. We found that adverse sleep patterns were significantly associated with the transition from health to FCVD, from FCVD to CVM, and from health to death, with hazard ratio associated with 1‐factor increase in sleep scores being 1.08 (95% CI, 1.07–1.09), 1.04 (95% CI, 1.02–1.06), and 1.04 (95% CI, 1.02–1.05), respectively. When further dividing FCVD into coronary heart disease, stroke, atrial fibrillation, and heart failure, adverse sleep patterns showed a significant and persistent effect on the transition from health to each cardiovascular disease, and from heart failure or atrial fibrillation to CVM.

Conclusions
Our study provides evidence that adverse sleep patterns might increase the risk for the progression from health to cardiovascular diseases and further to CVM. Our findings suggest that improving sleep behaviors might be helpful for the primary and secondary prevention of cardiovascular diseases.
Assessment of the Effects of Sodium Nitroprusside Administered Via Intracranial Subdural Catheters on the Cerebral Blood Flow and Lactate Using Dynamic Susceptibility Contrast Magnetic Resonance Imaging and Proton Magnetic Resonance Spectroscopy in a Pig Cardiac Arrest Model
Authors: Lee Hyoung Youn , Jung Yong Hun , Mamadjonov Najmiddin , Jeung Kyung Woon , Lee Byung Kook , Kim Tae‐Hoon , Kim Hyung Joong , Gumucio Jorge Antonio , Salcido David D. 
Published: September 2023

Background
Cerebral blood flow (CBF) is impaired in the early phase after return of spontaneous circulation. Sodium nitroprusside (SNP) administration via intracranial subdural catheters improves cerebral cortical microcirculation. We determined whether the SNP treatment improves CBF in the subcortical tissue and evaluated the effects of this treatment on cerebral lactate.

Methods and Results

Sixty minutes after return of spontaneous circulation following 14 minutes of untreated cardiac arrest, 14 minipigs randomly received 4 mg SNP or saline via intracranial subdural catheters. CBF was measured in regions of interest within the cerebrum and thalamus using dynamic susceptibility contrast‐magnetic resonance imaging. After return of spontaneous circulation, CBF was expressed as a percentage of the baseline value. In the saline group, the %CBF in the regions of interest within the cerebrum remained at approximately 50% until 3.5 hours after return of spontaneous circulation, whereas %CBF in the thalamic regions of interest recovered to approximately 73% at this time point. The percentages of the baseline values in the cortical gray matter and subcortical white matter were higher in the SNP group (group effect
P
=0.026 and 0.025, respectively) but not in the thalamus. The cerebral lactate/creatine ratio measured using magnetic resonance spectroscopy increased over time in the saline group but not in the SNP group (group–time interaction
P
=0.035). The thalamic lactate/creatine ratio was similar in the 2 groups.

Conclusions
SNP administered via intracranial subdural catheters improved CBF not only in the cortical gray matter but also in the subcortical white matter. The CBF improvement by SNP was accompanied by a decrease in cerebral lactate.
The Cyrenaics on the Premeditation of Future Evils
Authors: Chouinard Isabelle 
Published: September 2023

Abstract
In Book 3 of the Tusculans, Cicero reports that the Cyrenaics practised the premeditation of future evils. This article focuses on the philosophical consistency of this exercise with other Cyrenaic testimonies. It argues for the authenticity of Cicero’s report and provides a critical survey of previous attempts to reconstruct the theory underlying Cyrenaic premeditation, which addresses crucial questions about the management of future pleasures and pains, and the duration of affections. New evidence from Diogenes Laertius 2.94 is then used to support an alternative interpretation of the Cyrenaic praemeditatio malorum.
Speech Act Set in TripAdvisor Conflictive Exchanges
Authors: Hernández Toribio María Isabel , Mariottini Laura 
Published: September 2023

Abstract
In the present article, taking a ‘polylogal’ perspective, we carry out a cross-linguistic analysis of speech act sets in conflictive exchanges (SASCs) on TripAdvisor (TA) in Spanish and Italian. These exchanges involve, on one hand, reviewer opinions concerning hospitality and travel experiences and, on the other, hospitality/travel-industry representative responses to form a review-response pair that is part of a polylogue with other TA users. These exchanges are characterised as potentially conflictive since, where travellers rate their experiences as poor, this micro-act of complaint may be responded to in a more or less confrontational fashion with hospitality-industry representatives responding in ways that either encourage, minimise, or avoid conflict.
Our research is based on a total of 1,000 TripAdvisor (TA) posts forming two sub-corpora (Spanish and Italian) each of 500 review-response pairs where users gave opinions concerning their experiences of certain hotels or restaurants and were responded to by representatives from these hotels or restaurants. Our objective is to analyse these SASCs in order to identify a) the different categories of SASCs used in, firstly, reviews (opposition) and, secondly, in responses (reactions); b) to what extent each of these categories are used; c) if there is variation between the Spanish and Italian sub-corpora in terms of the use of different types of SASCs in opposition and reaction, and finally, d) how this variation might be related to sociocultural factors in the two sub-corpora. Data show several dissimilarities between the Spanish and Italian sub-corpora in terms of communication strategies used on the TA platform. For example, Italian hotel/restaurant representatives adopted a confrontational style using mostly unmitigated disagreement, acts of disqualification or self-praise while, in contrast, Spanish respondents were more supportive using mostly convivial acts, mitigating supportive moves and linguistic strategies.
Besides giving a range of insights into cross-cultural variation in digital communication strategies, this work also provides a methodological model for the analysis of macro conflictive speech acts and their modification strategies. It is hoped that this model will prove useful in future research concerning digital communication, especially TA exchanges.
Credible messengers, formers, and anti-war veterans: Former fighters as resources for violence/war disruption
Authors: Wallace M.S. 
Published: September 2023

Abstract
This article considers an unlikely source for non-militarized approaches to disrupting war and other forms of violence: fighters themselves. How can engaging with fighters/former fighters realize novel forms of violence/war disruption across various contexts, and what are the barriers to and implications of such engagement? Fighters’ exit from their armed organizations can be a source of violence/war disruption in two ways: first, through the sheer act of leaving and thereby diminishing the fighting capability of an armed organization, and, second, through using their credibility as former fighters to engage in activism to influence other current fighters, as well as the broader public, to refuse participation in or support for violence/war. Examining the work of “credible messengers,” “formers,” and anti-war veterans to disrupt street violence, extremist violence, and wartime violence, respectively, reveals surprising commonalities among them, as well as strikingly different reactions to their respective forms of disengagement/refusal and the policies they require.
Steroid-Eluting Implants: An Adjunctive Therapy After Double-Stage Laryngotracheal Reconstruction
Authors: Drury Emily , Anderson Brian , Haupert Michael , Thottam Prasad John 
Published: September 2023

Objectives: The primary objective is to describe a case in which a steroid-eluting implant was utilized to help prevent postoperative granulation and restenosis in a patient who underwent double-stage laryngotracheal reconstruction (dsLTR) for subglottic stenosis. Methods: This case presents a 3-year-old female who underwent dsLTR with anterior cartilage graft placement and posterior sagittal split for subglottic stenosis. A silicone stent was placed at the time of the dsLTR. After stent removal, direct laryngoscopy and bronchoscopy (DLB) was performed at 4 to 5 week intervals. These visits revealed a significant amount of supraglottic and glottic edema, and granulation tissue at the proximal aspect of the graft contributing to airway obstruction and restenosis. This was treated twice with CO2 laser excision, balloon dilation, and triamcinolone injection. On the third treatment with these modalities, a mometasone furoate implant was inserted as an adjunctive therapy. The implant was inserted to lateralize the vocal folds, prevent webbing, and to extend to the narrowed area within the subglottis to prevent granulation and restenosis. These same treatments were repeated at the fourth visit with another mometasone furoate implant of a smaller size placed in the same location. Results: Findings on DLB since treatment with the steroid-eluting implants have shown persistent granulation tissue limited to the tracheostomy stoma site. Treatments with CO2 laser, balloon dilation, and triamcinolone injection have continued, with occasional use of silver nitrate cautery at the external stoma site. There has not been any significant evidence of edema, granulation, or stenosis in the glottis or subglottis to require another steroid-eluting implant. Conclusions: Steroid-eluting implants appear to be a safe and effective adjunctive therapy in the routine surveillance of pediatric patients with a tracheostomy who have undergone dsLTR. They may help combat granulation formation and restenosis seen in some dsLTR patients.
Analysts’ Institutional Client Catering and Reputation Tradeoff: Strategic Timing of Recommendations
Authors: Agapova Anna , Filatova Uliana 
Published: September 2023

We examine whether sell-side analysts strategically time their favorable recommendations to cater to institutional investors while preserving analysts’ reputational capital. Although prior literature documents that analysts provide more positive recommendations for stocks that are part of their institutional clients’ (specifically, mutual funds’) portfolios, it does not explicitly address a reputation cost associated with such practice. Using a sample of analysts’ recommendations on U.S. firms for the 2002–2017 period, we document a pattern of analysts’ recommendations being more optimistic in the end month of a quarter and less optimistic in the beginning month of a quarter. This timing pattern ties to quarterly reporting periods of portfolio managers, with actively managed mutual funds’ holdings being affected the most. Analysts with Institutional Investor All-Star ranking do not engage in such stock recommendation timing practices. The market participants seem to believe rosy recommendations issued for stocks with more institutional holdings in the end month of a quarter with more positive cumulative abnormal returns to upgrade and downgrade recommendations. JEL classifications: G14, G24
Comparative analysis of standard, tubeless and total tubeless percutaneous nephrolithotomy: A prospective study
Authors: Kamble Vaibhav Balu , Gupta Sandeep , Pal Dilip Kumar 
Published: September 2023

Introduction: This study was done to review and compare safety, effectiveness and advantages of total tubeless percutaneous nephrolithotomy (PCNL), tubeless PCNL with standard PCNL. Methodology: This prospective comparative study involving 30 patients in each total tubeless PCNL, tubeless PCNL and standard PCNL group from Feb 2021 to June 2022. Result: Significant difference was found in mean duration of surgery ( p < 0.01), mean hospital stay ( p < 0.01), mean VAS post op score ( p < 0.01), mean time to return to normal activity ( p < 0.01) in total and tubeless PCNL group as compared with standard PCNL. While no significant difference found in mean haemoglobin drop ( p = 0.1417), blood transfusion ( p = 3721), incidence of urine leak ( p = 0.13), need of accessory secondary procedure ( p = 0.1322) and associated complications ( p = 0.5939) among three groups. Conclusion: Study observed that total tubeless, tubeless PCNL is a safe and efficient technique. It is significantly associated with the advantages of shorter hospital stay, shorter time to return to normal activity, lower postoperative pain scores. Total tubeless PCNL obviates need of second procedure of removing DJ stent. Standard, tubeless and total tubeless PCNL have similar post op complication rate. Study thus concludes that total tubeless, tubeless PCNL can be used as a substitute for traditional standard PCNL.
Homologous Recombination Abnormalities Associated With BRCA1/2 Mutations as Predicted by Machine Learning of Targeted Next-Generation Sequencing Data
Authors: Albitar Maher , Zhang Hong , Pecora Andrew , Waintraub Stanley , Graham Deena , Hellmann Mira , McNamara Donna , Charifa Ahmad , De Dios Ivan , Ma Wanlong , Goy Andre 
Published: September 2023

Background: Homologous recombination deficiency (HRD) is the hallmark of breast cancer gene 1/2 ( BRCA1/2)-mutated tumors and the unique biomarker for predicting response to double-strand break (DSB)–inducing drugs. The demonstration of HRD in tumors with mutations in genes other than BRCA1/2 is considered the best biomarker of potential response to these DSB-inducer drugs. Objectives: We explored the potential of developing a practical approach to predict in any tumor the presence of HRD that is similar to that seen in tumors with BRCA1/2 mutations using next-generation sequencing (NGS) along with machine learning (ML). Design: We use copy number alteration (CNA) generated from routine-targeted NGS data along with a modified naïve Bayesian model for the prediction of the presence of HRD. Methods: The CNA from NGS of 434 targeted genes was analyzed using CNVkit software to calculate the log2 of CNA changes. The log2 values of various sequencing reads (bins) were used in ML to train the system on predicting tumors with BRCA1/2 mutations and tumors with abnormalities similar to those detected in BRCA1/2 mutations. Results: Using 31 breast or ovarian cancers with BRCA1/2 mutations and 84 tumors without mutations in any of 12 homologous recombination repair (HRR) genes, the ML demonstrated high sensitivity (90%, 95% confidence interval [CI] = 73%-97.5%) and specificity (98%, 95% CI = 90%-100%). Testing of 114 tumors with mutations in HRR genes other than BRCA1/2 showed 39% positivity for HRD similar to that seen in BRCA1/2. Testing 213 additional wild-type (WT) cancers showed HRD positivity similar to BRCA1/2 in 32% of cases. Correlation with proportional loss of heterozygosity (LOH) as determined using whole exome sequencing of 51 samples showed 90% (95% CI = 72%-97%) concordance. The approach was also validated in an independent set of 1312 consecutive tumor samples. Conclusions: These data demonstrate that CNA when combined with ML can reliably predict the presence of BRCA1/2 level HRD with high specificity. Using BRCA1/2 mutant cases as gold standard, this ML can be used to predict HRD in cancers with mutations in other HRR genes as well as in WT tumors.