bluuebunny/crossref_metadata_2025_split huggingface dataset:
Photoresponsive Bio‐Heterojunctions Eliciting Immunogenicity to Prevent Infection Recurrence and Accelerating Chronic Wound Regeneration
Authors: Yang Yingming , Liang Kunneng , Zhou Zilin , Tu Yuanyuan , Li Meng , Wang Ziyou , Deng Yi , Li Jiyao 
Published: January 2025

AbstractDynamic therapy utilizes reactive oxygen species (ROS) to antibacterial and enhance the innate immune system to treat bacterial infections. If ROS levels are too low, the elimination of pathogens and the enhancement of innate immunity cannot be achieved. However, excess accumulation of ROS may impact intracellular glutathione (GSH) levels, hindering T cell maturation and the establishment of immune memory. Herein, a multifunctional nanofiber membrane is designed, consisting of a polymer scaffold, MXene/CeO2 bio‐heterojunctions (MX@Ce bio‐HJs), and lactate oxidase (Lox) to balance the production of ROS, for the treatment of recurrent bacterial infections. In this system, MX@Ce bio‐HJs upon near‐infrared ray (NIR) generate photodynamic therapy, while Lox responds to the wound microenvironment exert chemodynamic therapy, synergistically produce ROS to rapidly eradicate bacteria, amplify the ability of dendritic cells to recognize and present antigens of bacterial fragments, and enhance innate immunity. Without NIR, MX@Ce bio‐HJs showcase catalase‐like and superoxide dismutase‐like activities, scavenging subsequent ROS accumulation, promoting T cell maturation to form acquired immune memory, and combating recurrent bacterial infection. Such work highlights the potential to combat in situ bacterial infections and recurrent bacterial infections and inspires the development of future antibacterial therapies.
Enhancement Mechanism of Photo‐Induced Artificial Boundary on Ultrastable Hybrid Solid‐electrolyte Interphase of Si Anodes
Authors: Xu Zeyu , Liu Zhenzhuo , Shao Haibo , Liu Yingchun , Wang Jianming 
Published: January 2025

AbstractUnstable solid‐electrolyte interphase (SEI) film resulting from chemically active surface state and huge volume fluctuation limits the development of Si‐based anode materials in lithium‐ion batteries. Herein, a photo‐initiated polypyrrole (PPy) coating is manufactured on Si nanoparticles to guide the in situ generation of PPy‐integrated hybrid SEI film (hSEI). The hSEI film shows excellent structure stability and optimized component composition for lithium storage. More promisingly, the photo‐initiated hSEI precursor with more uniform thickness, stronger interaction with inner particles, and higher mechanical strength further enables the structural integrity of the hSEI film. The highly ordered interchain structure of photo‐initiated hSEI precursor can maintain effective Li+ transport during the electrochemical cycling. Consequently, SiNPs@hSEI‐L anode maintains a reversible capacity of 1044.7 mAh g−1 after 500 cycles at 2 A g−1, manifesting superior electrochemical lithium storage. This work proposes a novel polymer‐integrated hSEI formation and provides an effective reference for the optimization of semiconductor materials.
Platinum/(Carbon‐Nanotube) Electrocatalyst Boosts Hydrogen Evolution Reaction in Acidic, Neutral and Alkaline Solutions
Authors: Liu Yi , Liu Peng , Cai Yingying , Zhu Minghui , Dou Ning , Zhang Lei , Men Yu‐Long , Pan Yun‐Xiang 
Published: January 2025

AbstractWidely used catalysts for electrocatalytic hydrogen (H2) evolution reaction (HER) have high platinum (Pt) contents and show low efficiencies in neutral and alkaline solutions. Herein, a carbon nanotube (CNT) supported Pt catalyst (Pt/CNT45) with 1 wt.% Pt is fabricated. For HER, the mass activity of Pt/CNT45 in acidic (18.76 A mgPt−1), neutral (3.92 A mgPt−1), and alkaline (3.88 A mgPt−1) solutions is respectively much higher than those on commercial Pt/C catalyst with 20 wt.% Pt (acidic: 0.31 A mgPt−1, neutral: 0.03 A mgPt−1, alkaline: 0.07 A mgPt−1). Thus, Pt/CNT45 enhances HER not only in acidic solutions but also in neutral and alkaline solutions. Ptδ+ at Pt‐CNT interface on Pt/CNT45 promotes water (H2O) dissociation and hydroxyl (OH) desorption from Pt/CNT45, thus enhancing HER. This work opens a new way for enhancing HER in a wider pH range by catalyst with low Pt content, and helpful for commercialization.
Generating Beta Zeolite Nanosheets of Intergrown Polymorph B and C Using Polycationic Structure‐Directing Agent
Authors: Qie Guanyu , Liu Runze , Deng Quanzheng , Deng Donghao , Zhai Miao , Liu Wei , Dai Weili , Han Lu , Zhu Kake 
Published: January 2025

AbstractZeolitic nanosheets possess great potential in catalysis due to their enhanced transport property and accessibility toward bulky molecules compared to conventional micron‐ meter scale crystals. However, the generation of Beta zeolite nanosheets, which are crucial for industrial catalysis, is still challenging for its intergrowth nature. In this work, aluminosilicate Beta nanosheets of ca. 16 nm thick with house‐of‐cards architecture are generated using a special polycationic organic structure directing agent (OSDA), [‐N+(CH3)2‐C5H10‐N+(CH3)2‐C6H12‐]n[Br−]2n, in greener hydroxide media. Transmission electron microscopy and electron tomography reconstruction revealed that the nanosheets are composed of unprecedented intergrowth of polymorphs B and polymorph C (i.e., BEC topology), possessing only straight micropore channels. 2D 29Si{1H} and 27Al{1H} heteronuclear correlation NMR spectra reveal that the framework Al atoms are mainly situated close to the ammonium moieties of the OSDA inside straight channels, owing to a strong OSDA‐framework attraction. The selectivities of ethylene, propylene and catalyst lifetime have been promoted in n‐heptane cracking, due to stronger acidity and enhanced diffusion property. Moreover, the architecture is robust toward deep dealumination and Ti‐ modification, allowing it to be a superior catalyst in cyclohexene epoxidation. The polycation OSDA design concept and the recipe for Beta nanosheets may find broader applications in catalysis.
MXene Nanoribbon Aerogel‐Based Gradient Conductivity Electromagnetic Interference Shields with Unprecedented Combination of High Green Index and Shielding Effectiveness
Authors: Roy Sanjoy Sur , Ghosh Koushik , Meyyappan M. , Giri P. K. 
Published: January 2025

AbstractThe desire to reduce secondary pollution from shielded electronics devices demands electromagnetic interference (EMI) shields with high green index (GI), which is the ratio of absorbance over reflectance. Achieving high GI values simultaneously with high shielding effectiveness (SE) over 50 dB is a serious unresolved challenge. Reducing the impedance mismatch between the shield and free space is the key to reducing the reflection of incoming radiation and enabling more penetration into the body of the shield for absorption. Here a sandwich structure with gradient conductivity is introduced that achieves a combination of high GI (≈2) and SE (70 dB). The top layer deliberately uses an aerogel of low conductivity MXene nanoribbon in PEDOT:PSS polymer to boost the GI. The aerogel also reduces the permittivity of the shield, as another way to reduce the impedance mismatch for a nonmagnetic material. The bottom layer consists of a MXene nanosheet–polymer with its high metal‐like conductivity to provide high SE. This successful demonstration is expected to lead to other novel ways to create conductivity gradient EMI shields.
Intravitreal Administration of Adalimumab‐Loaded Poly(Lactic‐co‐Glycolic Acid) Nanoparticles: Effects on Biodistribution and Pharmacokinetics
Authors: García‐Otero Xurxo , Varela‐Fernández Rubén , Cuartero‐Martínez Andrea , Gómez‐Lado Noemí , González‐Barcia Miguel , Mondelo‐García Cristina , Feitosa Carolina , Aguiar Pablo , Fernández‐Ferreiro Anxo , Otero‐Espinar Francisco J. 
Published: January 2025

Adalimumab, a monoclonal antibody used for treating inflammatory diseases, including eye diseases, faces challenges in biodistribution and targeted delivery. Nanoparticle (NP)‐based drug delivery systems have shown promise in enhancing the pharmacokinetic profiles of biologic drugs. This study aims to develop, and characterize intravitreal adalimumab‐loaded poly(lactic‐co‐glycolic acid) (PLGA) NPs to improve antibody distribution and therapeutic efficacy. Characterization studies, morphological examination, and quantitative, stability, and physical properties are conducted. In vitro release kinetics are assessed using a dialysis membrane method. In vivo biodistribution is studied in rats after intravitreal administration by Positron Emission Tomography/Computed Tomography imaging. The optimized NPs were spherical (around 300 nm) with a surface charge of about −20 mV. Encapsulation efficiency and drug loading reach values close to 100%. Stability studies showed minimal changes in particle size and drug content. In vitro release showed a biphasic pattern with an initial burst release followed by sustained release. Safety studies indicated no significant cytotoxicity or adverse effects. The adalimumab‐loaded PLGA NPs demonstrate favorable physicochemical characteristics, stability, and release profiles. In vivo distribution revealed a change in the antibody's distribution pattern after intravitreal administration via NPs encapsulation. These findings suggest the potential for enhanced therapeutic outcomes and warrant further investigation in disease‐specific models to explore the clinical potential of this NP‐based delivery system.
Spatial Analysis of Informal Recyclable Station System for Integration to Formal Solid Waste Management System and Circular Economy–Proposing Integrated Methodology of GIS, Remote Sensing, and Statistical Learning
Authors: Dinh Cuong Le , Fujiwara Takeshi , Phu Song Toan Pham 
Published: January 2025

AbstractRecently, the transition to the circular economy has become environmentally and economically urgent for every single nation in the world. Closing the loops of material is one of the key ideas behind the foundation of a circular economy (CE). The informal recyclable stations (IRSs) within the solid waste management (SWM) system play an important role as the reversed logistic system, being in charge of collecting and trading recyclable solid waste. This study aimed to comprehend the spatial nature of the system of IRSs in Danang city, Hue city, and Hoi An city as representative sites for the whole of central Vietnam and the nation. The integration of geographic information system (GIS), remote sensing, and statistical learning was performed to clarify spatial characteristics and dynamics of the system of IRSs as well as combat status of limitations of available data in developing countries. Results denoted that the system of IRSs was distributed in close proximity to transportation systems and residential areas with low vegetation coverage. Coverage ratios of the system of IRSs did not strongly fluctuate in case the number of IRSs decreased by 80% regarding the 3500 m distance covered. Negative binomial regression proved to be the most congruent model for understanding the prevalence of IRSs in central Vietnam. Population and normalized difference vegetation index were statistically related to prevalence of IRS. While linear regression depicted balance between variance and bias, support vector machine would be applied if prioritized aim is model performance. The results of this study are a scientific base for the management of the IRS system and the integration of this system into a formal SWM system as well as the transition to a CE.
Positionality
Authors: Murray Emily Margaret , Anta Alba Hernandez , Montaña Monoga Ana Maria , Quist Sofie Elise 
Published: January 2025

Abstract
This chapter explores the concept of positionality as one of the main themes of the OIN Ocean Literacy Toolkit. It draws on positionality theory and anti-oppressive, decolonial research methodologies that incorporate positionality as a reflexivity tool in social research. Drawing on Donna Haraway’s seminal essay on “Situated Knowledges”, the chapter elaborates on questions that researchers might ask themselves to understand the ways in which their positionality influences how they come to know the Ocean and how they may edge towards epistemic justice. Thus, linking positionality to epistemology, the chapter charts how multiple ways of knowing the Ocean is surfacing in both academic scholarship and policy. Finally, the authors connect and translate the main dimensions to the two pathways “connecting with each other” and “connecting with the ocean” and introduce the positionality activities included in the OIN Toolkit.
Deutschlandweite Evaluation der ärztlichen Weiterbildung in Psychiatrie und Psychotherapie
Authors: Schubotz Nina , Kronsbein Julia-Maleen , Zapp Angela , Reichel Rebecca 
Published: January 2025

Zusammenfassung

Hintergrund
Bislang existiert keine Evaluation der Weiterbildungs- und Arbeitsbedingungen in der Facharztweiterbildung Psychiatrie und Psychotherapie in Deutschland. Um dem Nachwuchsmangel entgegenzuwirken und die Versorgung der Patient:innen langfristig sicherzustellen, ist eine Qualitätssicherung unabdingbar.

Ziel der Arbeit
Ziel der Evaluation ist es, Stärken und Schwächen der Weiterbildung zu identifizieren und Maßnahmen zur Verbesserung abzuleiten. Für eine bessere Einordnung wird außerdem ein Vergleich mit anderen Facharztweiterbildungen vorgenommen.

Material und Methoden
Die onlinebasierte Befragung erfolgte vom 15.05.2023 bis zum 30.06.2023. Die Ergebnisse beziehen sich auf 315 Fragebögen von 202 Ärzt:innen in Weiterbildung und 113 Fachärzt:innen (Facharzttitel seit weniger als 3 Jahren).

Ergebnisse
Insgesamt 64 % der Befragten sind mit Qualität und Umsetzung des allgemeinen Psychiatrie-Teils zufrieden, nur 11 % erwägen aufgrund der Weiterbildungsbedingungen einen Wechsel der Fachrichtung und 18 % eine Verlegung ihres Arbeitsplatzes ins Ausland. Verbesserungsbedarf zeigt sich bei der Einarbeitung sowie bei der Organisation der Weiterbildung. Zudem werden ein erheblicher Zeit- und Kostenaufwand für verpflichtende externe Weiterbildungsveranstaltungen und eine mangelnde Vereinbarkeit der Weiterbildung mit Forschung, Lehre und Care-Arbeit beanstandet.

Diskussion
Insgesamt zeigt sich, dass die Arbeitsbedingungen besser sind als in anderen Fächern. Hinsichtlich des Verbesserungspotenzials ist die Schaffung einer Finanzierung der Weiterbildung unerlässlich, zudem können Zertifikate für gute Weiterbildung sowie die Veröffentlichung von Positivbeispielen zur Qualitätssicherung und -verbesserung beitragen.
Levelling-up national economies through regional development? a panel fsQCA approach applied to Great Britain
Authors: Huggins Robert , Thompson Piers , Beynon Malcolm , Pickernell David , Jones Paul 
Published: January 2025

Abstract
There is currently renewed policy focus on ‘levelling-up’ economic performance across Great Britain’s regions and nations. Heterogeneous historical regional economic experiences lead to questions over the need for policy differences and trade-offs, and roles of regional, versus national level, policies in the longer term. This paper examines, using panel fuzzy-set qualitative comparative analysis (fsQCA), combinations of education and human capital, entrepreneurship, and economic activity conditions driving economic development differences across local authorities in Great Britain. Analysis identifies three and six condition-based pathways for the presence and absence of high local economic development (LED), respectively, absence pathways having a particular geographical focus. This identifies different sets of regions, where disadvantage is ‘deep-rooted’ (and non-traditional policymaking is needed), advantage is long-established, or where policy is most likely to make a positive difference. It also identifies a need to tailor policy according to the pathway(s), rather than assuming homogeneous approaches are appropriate. Finally, exemplar regions offer case studies of how future policy can assist movement from absence to presence of high LED.
Nonparametric testing of first-order structure in point processes on linear networks
Authors: González-Pérez Ignacio , Borrajo María Isabel , González-Manteiga Wenceslao 
Published: January 2025

Abstract
In this paper we address a two-sample problem in the context of point processes on linear networks. The aim is to determine whether two given point patterns defined over the same linear network and under the assumption of Poissonness, share the same spatial structure. To do so, a Kolmogorov–Smirnov and a Cramér von Mises type test statistics are developed and analysed through an extensive simulation study. We have included different types of networks, balanced and unbalanced sample sizes, and homogeneous and inhomogeneous Poisson point processes. The results show a good level adjustment and high power values, the latter increasing with the sample size and the discrepancy between the two generating intensities. Finally, these methods have also been applied to the analysis of traffic accidents in Rio de Janeiro (Brazil), studying their distribution at different rush hours.
Compositional Sparsity, Approximation Classes, and Parametric Transport Equations
Authors: Dahmen Wolfgang 
Published: January 2025

Abstract
Approximating functions of a large number of variables poses particular challenges often subsumed under the term “Curse of Dimensionality” (CoD). Unless the approximated function exhibits a very high level of smoothness the CoD can be avoided only by exploiting some typically hidden structural sparsity. In this paper we propose a general framework for new model classes of functions in high dimensions. They are based on suitable notions of compositional dimension-sparsity quantifying, on a continuous level, approximability by compositions with certain structural properties. In particular, this describes scenarios where deep neural networks can avoid the CoD. The relevance of these concepts is demonstrated for solution manifolds of parametric transport equations. For such PDEs parameter-to-solution maps do not enjoy the type of high order regularity that helps to avoid the CoD by more conventional methods in other model scenarios. Compositional sparsity is shown to serve as the key mechanism for proving that sparsity of problem data is inherited in a quantifiable way by the solution manifold. In particular, one obtains convergence rates for deep neural network realizations showing that the CoD is indeed avoided.
Variable treatment response to lumasiran in pediatric patients with primary hyperoxaluria type 1
Authors: Saffe Sina , Doerry Katja , Büscher Anja K. , Hansen Matthias , Rohmann Melanie , Kanzelmeyer Nele , Latta Kay , Kemper Markus J. , Loos Sebastian 
Published: January 2025

Abstract

Background
Primary hyperoxaluria type 1 (PH 1) is a rare genetic condition due to mutations in the AGXT gene. This leads to an overproduction of oxalate in the liver. Hyperoxaluria often causes kidney stones, nephrocalcinosis, and chronic kidney disease. Lumasiran is a recently approved drug that reduces the hepatic oxalate production by mRNA interference.

Methods
In this multicenter study, we evaluated the response to lumasiran treatment in PH 1 patients (n = 8) with a median age of 10.9 years (range 1.2–17.9 years), including two patients on hemodialysis. We retrospectively analyzed the reduction of urinary and plasma oxalate levels as well as changes in kidney stone events, nephrocalcinosis, and kidney function.

Results
In patients without kidney failure, the median reduction of urinary oxalate was 64% (range 10–80%) and 71% (61–86%) at 6 and 12 months, respectively. However, only one patient reached urinary oxalate levels within the age-specific normal range. Two patients did not respond to lumasiran and treatment was stopped. In one of the two patients on hemodialysis, the frequency of sessions could be reduced. The only notable side effects were injection site reactions.

Conclusion
There was a variable response to lumasiran in PH 1. Despite a reduction of hyperoxaluria in many patients with PH 1, only one patient reached normal values and 2 of 8 patients did not respond. Regular monitoring of urinary oxalate values and registry data collection seems mandatory to monitor the efficacy and the long-term outcome of PH 1 treated with lumasiran.

Graphical Abstract
Anterior communicating aneurysm clipping: How I do it
Authors: Vernile Bruno , Palmisciano Paolo , Vadivelu Sudhakar , Zuccarello Mario 
Published: January 2025

Abstract
Up to 40% of intracranial aneurysms arise from the anterior cerebral artery and anterior communicating artery (ACA-ACoA) complex. The vast variability of vessel anomalies and the surrounding critical structures correlate with severe morbidity and mortality rates in case of rupture. In the era of cutting-edge advantages of endovascular procedures, surgical expertise is reducing. This article describes our institutional surgical technique in managing ACoA aneurysms, focusing on anatomical variants, approach selection, and technical intraoperative nuances.
Cognitive representation of gait: differences in memory structures between individuals after total knee arthroplasty and total hip arthroplasty
Authors: Linnhoff Dagmar , Kaiser René , Mattes Klaus , Frank Cornelia 
Published: January 2025

Abstract
The objective was to examine differences in the gait-specific cognitive representation structures between individuals after total knee- (TKA) and after total hip-joint arthroplasty (THA). The cognitive representation structure was compared between three groups: 1. three months after TKA (n = 12), 2. three months after THA (n = 12), and 3. healthy control group (CG) (n = 12) using the structural dimensional analysis of mental representation (SDA-M). Additionally, perceived joint function was rated by either the KOOS, JR. or HOOS, JR. Mean distribution of perceived joint function was not significantly different between the TKA (60.35 ± 11.2) and THA group (68.01 ± 13.8) (t = − 1.425; p = .173). In the cognitive representation structure, the THA group exhibited functional differences from the TKA group and control group, both of which showed a functional structure. Three months after hip joint replacement the gait-specific cognitive representation structure seems to reflect joint function-specific deviations. Therefore, focussing on functional recovery of cognitive gait representation may facilitate gait rehabilitation in individuals after hip replacement.
Cohort profile: the provincial opioid agonist treatment cohort in Ontario, Canada
Authors: Morin Kristen A. , Tatangelo Mark R. , Acharya Shreedhar , Marsh David C. 
Published: January 2025

Abstract

Background
Opioid Agonist Treatment (OAT) is the most effective intervention for opioid use disorder (OUD), but retention has decreased due to increasingly potent drugs like fentanyl. This cohort can be used retrospectively to observe trends in service utilization, healthcare integration, healthcare costs and patient outcomes. It also facilitates the design of observational studies to mimic a prospective design.

Methods
This study used linked administrative data from ICES to create a cohort of 137,035 individuals who received at least one prescription of methadone or buprenorphine/naloxone between 2014 and 2022. Data were linked using de-identified personal health numbers. Variables included age, sex, rurality, income, homelessness, and mental health conditions. Regional differences in OAT use, retention, and mortality were analyzed.

Results
Of the cohort, 56.1% began OAT after 2014. Southern Ontario participants more often started on methadone (53.2%), while Northern Ontario patients favored buprenorphine/naloxone (62.7%). Northern patients were younger, more likely to be female, live in rural areas, and face homelessness. The death rate was higher in Southern Ontario (22.1%) than in Northern Ontario (13.2%). Retention declined over time, with 73.4% of patients remaining in treatment at the study's end.

Conclusions
The findings highlight regional disparities in OAT delivery and emphasize the need for region-specific strategies, particularly in rural areas, to improve retention and reduce mortality.