bluuebunny/crossref_metadata_2025_split huggingface dataset:
Changes in immune cell populations following KappaMab, lenalidomide and low‐dose dexamethasone treatment in multiple myeloma
Authors: Norton Samuel E , Khong Tiffany , Ramachandran Malarmathy , Highton Andrew J , Ward‐Hartstonge Kirsten A , Shortt Jake , Spencer Andrew , Kemp Roslyn A 
Published: November 2023

AbstractObjectivesLenalidomide (LEN) is used to treat multiple myeloma (MM) and shows in vitro synergy with KappaMab (KM), a chimeric antibody specific for Kappa Myeloma antigen, an antigen exclusively expressed on the surface of kappa‐restricted MM cells. Lenalidomide, dexamethasone (DEX) and KM control MM via multiple immunomodulatory mechanisms; however, there are several additional effects of the drug combination on immune cells. Lenalidomide can increase T cell and NKT cell cytotoxicity and dendritic cell (DC) activation in vitro. We investigated the immune cell populations in bone marrow of patients treated with KM, LEN and low‐dose DEX in kappa‐restricted relapsed/refractory MM ex vivo and assessed association of those changes with patient outcome.MethodsA cohort (n = 40) of patients with kappa‐restricted relapsed/refractory MM, treated with KM, LEN and low‐dose DEX, was analysed using a mass cytometry panel that allowed identification of immune cell subsets. Clustering analyses were used to determine significant changes in immune cell populations at time periods after treatment.ResultsWe found changes in five DC and 17 T‐cell populations throughout treatment. We showed an increase in activated conventional DC populations, a decrease in immature/precursor DC populations, a decrease in activated CD4 T cells and an increase in effector‐memory CD4 T cells and effector CD8 T cells, indicating an activated immune response.ConclusionThese data characterise the effects of LEN, DEX, and KM treatment on non‐target immune cells in MM. Treatment may support destruction of MM cells by both direct action and indirect mechanisms via immune cells.
Parasite transmission in size‐structured populations
Authors: Shaw Kelsey E. , Cloud Rebecca E. , Syed Raeyan , Civitello David J. 
Published: November 2023

AbstractHost heterogeneity can affect parasite transmission, but determining underlying traits and incorporating them into transmission models remains challenging. Body size is easily measured and affects numerous ecological interactions, including transmission. In the snail–schistosome system, larger snails have a higher exposure to parasites but lower susceptibility to infection per parasite. We quantified the effect of size‐based heterogeneity on population‐level transmission by conducting transmission trials in differently size‐structured snail populations and competing size‐dependent transmission models. Populations with greater proportions of large snails had lower prevalence, and small snails were shielded from infection by co‐occurring large conspecifics. Furthermore, a fully dependent transmission model that incorporated body size in both exposure and susceptibility outperformed other candidate models considered. Incorporating traits such as body size, which are affected by and directly affect host ecology, into transmission models could yield insights into natural dynamics and disease mitigation in many systems.
Optimal allocation of flexible AC transmission system (FACTS) for wind turbines integrated power system
Authors: Awad Ayman , Kamel Salah , Hassan Mohamed H. , Zeinoddini‐Meymand Hamed 
Published: November 2023

AbstractThe importance of flexible alternating current transmission system (FACTS) devices is increasing day by day as they provide compensation for power systems. The installation of such devices solves many issues regarding the stability and power transferability of power systems. However, for optimizing the performance of FACTS devices, the location and sizes of FACTS devices must be selected very carefully. On the other side, the utilization of optimization techniques is increasing daily, as it is capable of solving nonlinear, random problems by its stochastic nature. As a result, it became a reliable tactic for solving stochastic problems almost in every aspect of our lives. Therefore, it is adopted for solving power system problems, like, FACTS devices allocation, distributed generators allocation, determining component's parameters, and more. In this paper, the optimal size and location of several FACTS devices are selected to achieve the following single objective functions separately: fuel cost minimization and power losses minimization, then combining the mentioned objective function into one multiobjective function for gross cost minimization. The power system optimized is the Institute of Electrical and Electronics Engineers 30‐bus standard system, and the FACTS devices installed are static VAR compensator, thyristor control series compensator, and thyristor‐controlled phase shifter, while the optimization is performed using different conventional and recent optimization algorithms, including a newly developed algorithm, typically Leader Walrus Optimization Algorithm “LWaOA,” making a comparison among such algorithms to investigate the algorithm that possesses the best performance. The results of the optimization processes show the superiority of LWaOA.
Bibliometric analysis of cerebral organoids and diseases in the last 10 years
Authors: Luo Bo‐Yan , Liu Ke‐Qian , Fan Ji‐Sheng 
Published: November 2023

AbstractCerebral organoids have emerged as a powerful tool for mirroring the brain developmental processes and replicating its unique physiology. This bibliometric analysis aims to delineate the burgeoning trends in the application of cerebral organoids in disease research and offer insights for future investigations. We screened all relevant literature from the Web of Science on cerebral organoids in disease research during the period 2013–2022 and analyzed the research trends in the field using VOSviewer, CiteSpace, and Scimago Graphica software. According to the search strategy, 592 articles were screened out. The United States of America (USA) was the most productive, followed by China and Germany. The top nine institutions in terms of the number of publications include Canada and the United States, with the University of California, San Diego (USA), having the highest number of publications. The International Journal of Molecular Sciences was the most productive journal. Knoblich, Juergen A., and Lancaster, Madeline A. published the highest number of articles. Keyword cluster analysis showed that current research trends focused more on induced pluripotent stem cells to construct organoid models of cerebral diseases and the exploration of their mechanisms and therapeutic modalities. This study provides a comprehensive summary and analysis of global research trends in the field of cerebral organoids in diseases. In the past decade, the number of high‐quality papers in this field has increased significantly, and cerebral organoids provide hope for simulating nervous system diseases (such as Alzheimer's disease).
In relapsed or refractory diffuse large B‐cell lymphoma, CD19 expression by immunohistochemistry alone is not a predictor of response to loncastuximab tesirine
Authors: Caimi Paolo F. , Hamadani Mehdi , Carlo‐Stella Carmelo , Nickaeen Masoud , Jordie Eric , Utsey Kiersten , Knab Tim , Zammarchi Francesca , Cucchi Danilo , Pantano Serafino , Havenith Karin , Wang Ying , Boni Joseph 
Published: November 2023

AbstractCD19‐targeting treatments have shown promise in relapsed/refractory (R/R) diffuse large B‐cell lymphoma (DLBCL). Loncastuximab tesirine (loncastuximab tesirine‐lpyl [Lonca]) is a CD19‐targeting antibody‐drug conjugate indicated for R/R DLBCL after at least two systemic treatments. CD19 expression was evaluated in patients receiving Lonca in the LOTIS‐2 clinical trial with available tissue samples obtained after last systemic therapy/before Lonca treatment. Lonca cytotoxicity was evaluated in a panel of six lymphoma cell lines with various CD19 expression levels. Quantitative systems pharmacology (QSP) modelling was used to predict Lonca responses. Lonca responses were seen in patients across all CD19 expression levels, including patients with low/no detectable CD19 expression and H‐scores at baseline. Similarly, Lonca induced cytotoxicity in cell lines with different levels of CD19 expression, including one with very low expression. QSP modelling predicted that CD19 expression by immunohistochemistry alone does not predict Lonca response, whereas inclusion of CD19 surface density improved response prediction. Virtual patients responded to Lonca with estimated CD19 as low as 1000 molecules/cell of CD19, normally below the immunohistochemistry detection level. We found Lonca is an effective treatment for R/R DLBCL regardless of CD19 expression by immunohistochemistry. These results provide the basis for future studies addressing CD19‐targeted agent sequencing.
Extramammary Paget's disease with ureteral metastasis: A case report
Authors: Nakamura Shunsuke , Murayama Naoya , Satomi Naoyoshi , Kamio Yoshiyuki , Kuwatsuka Yutaka , Shida Yohei , Harada Junki , Hakariya Tomoaki , Sakai Hideaki , Okano Shinji , Murota Hiroyuki 
Published: November 2023

AbstractExtramammary Paget's disease (EMPD) is a skin cancer that can metastasize to distant lymph nodes and organs. However, there are no reports showing histological evidence of metastasis to the ureter. Here we report a case of EMPD that metastasized to the ureter in an 80‐year‐old man. The primary EMPD was resected and the right inguinal lymph node metastasis was dissected. Radiation therapy was administered around the right inguinal lymph nodes postoperatively. Four years later, a thickening of the wall of the right ureter was found, and a total right nephroureterectomy was performed due to suspicion of primary ureteral cancer. Histological examination showed nests of atypical cells in the renal adventitia and the surrounding lymphatic vessels, muscular layer and mucosal layer, but not in the ureteral epithelium. Immunohistochemical staining of tumour cells was positive for carcinoembryonic antigen, cytokeratin 7 and gross cystic disease fluid protein‐15 and was negative for cytokeratin 20. These results are consistent with a primary skin lesion. Although EMPD is not a frequent source of ureteral metastasis, EMPD can metastasize to the ureter. This case implies the feasibility of an accurate preoperative diagnosis through immunostaining, offering the potential to circumvent nephroureterectomy and instead facilitate appropriate management using a ureteral stent.
High‐frequency variability dominates potential connectivity between remote coral reefs
Authors: Vogt‐Vincent Noam S. , Mitarai Satoshi , Johnson Helen L. 
Published: November 2023

AbstractCoral larval dispersal establishes connectivity between reefs, but larval fluxes vary over timescales from daily to multidecadal due to oceanographic variability. Using a 2‐km‐resolution ocean model, we simulate daily spawning events from 1993 to 2019 and assess the potential connectivity between all reefs in the tropical southwest Indian Ocean. Although there is a significant seasonal cycle in potential connectivity, day‐to‐day variability generally dominates. Larval dispersal pathways on any particular day provide limited information about the dispersal pathways a few days later. The magnitude of this high‐frequency variability depends on the local geography and oceanography, with small and isolated reefs generally subject to the most variability. Stochastic oceanographic variability introduces considerable uncertainty to dispersal predictions, imposing fundamental limitations on what simulations can tell us about inter‐reef connectivity. Protracted spawning over only a few days can significantly reduce variability associated with the likelihood of a larva settling. The duration of spawning is therefore a more important parameter in modeling coral connectivity than the exact timing of spawning onset. Finally, we find that a small proportion of spawning events account for the majority of settling larvae, particularly at remote islands, and demonstrate that a time‐mean picture of dispersal may be inappropriate for predicting demographic and genetic connectivity. Given the diversity of coral reef environments in the southwest Indian Ocean, we expect that these results will apply to inter‐reef coral connectivity across the tropics more broadly, as well as other weakly swimming reef taxa with the potential for long‐distance dispersal.
Biofabrication of Cellulose‐based Hydrogels for Advanced Wound Healing: A Special Emphasis on 3D Bioprinting
Authors: Tabatabaei Hosseini Behina Sadat , Meadows Kieran , Gabriel Vincent , Hu Jinguang , Kim Keekyoung 
Published: November 2023

AbstractEven with the current advancements in wound management, addressing most skin injuries and wounds continues to pose a significant obstacle for the healthcare industry. As a result, researchers are now focusing on creating innovative materials utilizing cellulose and its derivatives. Cellulose, the most abundant biopolymer in nature, has unique properties that make it a promising material for wound healing, such as biocompatibility, tunable physiochemical characteristics, accessibility, and low cost. 3D bioprinting technology has enabled the production of cellulose‐based wound dressings with complex structures that mimic the extracellular matrix. The inclusion of bioactive molecules such as growth factors offers the ability to aid in promoting wound healing, while cellulose creates an ideal environment for controlled release of these biomolecules and moisture retention. The use of 3D bioprinted cellulose‐based wound dressings has potential benefits for managing chronic wounds, burns, and painful wounds by promoting wound healing and reducing the risk of infection. This review provides an up‐to‐date summary of cellulose‐based dressings manufactured by 3D bioprinting techniques by looking into wound healing biology, biofabrication methods, cellulose derivatives, and the existing cellulose bioinks targeted toward wound healing.
Mechanical properties and corrosion behavior of similar/dissimilar resistance spot welded automotive aluminum alloys
Authors: Kaya İ. , Başer T. A. , Kahraman N. 
Published: November 2023

AbstractRecently, usage of high strength aluminum alloys in automotive applications increase. The reasons for that increase are the light‐weight, high strength, good formability, weldability and corrosion resistance of the aluminum alloys to improve fuel economy as well as decreasing carbon dioxide emission. Automotive hybrid structures are commonly manufactured using dissimilar AA5000‐AA6000 joints to improve mechanical requirements and corrosion resistance of the parts. In this study, AA5754 H111‐AA6063 T4 materials were joined both similarly and dissimilarly by resistance spot welding method. Within the study, a mid‐frequency direct current technology was used instead of conventional alternative current technology. The welded zone was investigated by micro hardness measurements and microstructural characterization. Tensile‐shear and cross‐tension tests were performed. The welded zone of all welded specimens was subjected to salt spray corrosion test. A nugget pull‐out fracture mode was observed on the fracture surface of the all welded joints after tensile‐shear and cross‐tension tests. The lowest hardness values were measured from the weld metals for all welded joints. Porosity and inclusion were observed in the weld nugget with minor cracks in heat affected zone by optical microscope investigations.
Investigation of alternative RF power limit control methods for 0.5T, 1.5T, and 3T parallel transmission cardiac imaging: A simulation study
Authors: Petzold Johannes , Schmitter Sebastian , Silemek Berk , Winter Lukas , Speck Oliver , Ittermann Bernd , Seifert Frank 
Published: November 2023

AbstractPurposeTo investigate safety and performance aspects of parallel‐transmit (pTx) RF control‐modes for a body coil at .MethodsElectromagnetic simulations of 11 human voxel models in cardiac imaging position were conducted for , and and a body coil with a configurable number of transmit channels (1, 2, 4, 8, 16). Three safety modes were considered: the ‘SAR‐controlled mode’ (SCM), where specific absorption rate (SAR) is limited directly, a ‘phase agnostic SAR‐controlled mode’ (PASCM), where phase information is neglected, and a ‘power‐controlled mode’ (PCM), where the voltage amplitude for each channel is limited. For either mode, safety limits were established based on a set of ‘anchor’ simulations and then evaluated in ‘target’ simulations on previously unseen models. The comparison allowed to derive safety factors accounting for varying patient anatomies. All control modes were compared in terms of the amplitude and homogeneity they permit under their respective safety requirements.ResultsLarge safety factors (approximately five) are needed if only one or two anchor models are investigated but they shrink with increasing number of anchors. The achievable is highest for SCM but this advantage is reduced when the safety factor is included. PCM appears to be more robust against variations of subjects. PASCM performance is mostly in between SCM and PCM. Compared to standard circularly polarized (CP) excitation, pTx offers minor improvements if local SAR limits are always enforced.ConclusionPTx body coils can safely be used at . Uncertainties in patient anatomy must be accounted for, however, by simulating many models.
Social anxiety, self‐esteem and quality of life among hypertensive patients during COVID‐19 local epidemic in China: A mediation analysis
Authors: Gao Mengzhao , Lu Yidan , Zhang Lin , Shi Min , Zhou Haoran , Zhou Helian , Kuang Xia , Li Yuanzhen 
Published: November 2023

AbstractObjectivesTo explore the mediating role of self‐esteem in social anxiety and QoL during the COVID‐19 local epidemic in China.DesignA cross‐sectional survey.MethodsThis study conveniently selected 344 hypertensive patients from a Grade‐A tertiary hospital in Wuhu, Anhui Province, as the study population. Participants completed the demographic questionnaire, the social phobia inventory, the self‐esteem scale and the 36‐item short‐form health survey.ResultsSocial anxiety, self‐esteem and QoL were significantly correlated with each other. Social anxiety showed no direct effect on QoL (β = 0.011, p > 0.05). Social anxiety showed an indirect effect on QoL (β = −0.248, p < 0.001). Self‐esteem fully mediated the association between social anxiety and QoL in hypertensive patients.Patient or Public ContributionHypertensive patients in this study were participants during the data collection process. Nursing staff from the cardiology department at the hospital of a hospital in Wuhu City, Anhui Province assisted in the recruitment phase of the data collection process.
A text mining and network analysis of topics and trends in major nursing research journals
Authors: Oner Beratiye , Hakli Orhan , Zengul Ferhat D. 
Published: November 2023

AbstractAimThis study is set to determine the main topics of the nursing field and to show the changing perspectives over time by analysing the abstracts of several major nursing research journals using text mining methodology.DesignText mining and network analysis.MethodsText analysis combines automatic and manual operations to identify patterns in unstructured data. Detailed searches covering 1998–2021 were conducted in PubMed archives to collect articles from six nursing journals: Journal of Advanced Nursing, International Journal of Nursing Studies, Western Journal of Nursing Research, Nursing Research, Journal of Nursing Scholarship and Research in Nursing and Health. This study uses a four‐phase text mining and network approach, gathering text data and cleaning, preprocessing, text analysis and advanced analyses. Analyses and data visualization were performed using Endnote, JMP, Microsoft Excel, Tableau and VOSviewer versions. From six journals, 17,581 references in PubMed were combined into one EndNote file. Due to missing abstract information, 2496 references were excluded from the study. The remaining references (n = 15,085) were used for the text mining analyses.ResultsEighteen subjects were determined into two main groups; research method topics and nursing research topics. The most striking topics are qualitative research, concept analysis, advanced practice in the downtrend, and literature search, statistical analysis, randomized control trials, quantitative research, nurse practice environment, risk assessment and nursing science. According to the network analysis results, nursing satisfaction and burnout and nursing practice environment are highly correlated and represent 10% of the total corpus. This study contributes in various ways to the field of nursing research enhanced by text mining. The study findings shed light on researchers becoming more aware of the latest research status, sub‐fields and trends over the years, identifying gaps and planning future research agendas. No patient or public contribution.
The impact of psychological distress, socio‐demographic and work‐related factors on coping strategies used by nurses during the COVID‐19 pandemic: A cross‐sectional study
Authors: Rahmani Farnaz , Ranjbar Fatemeh , Asghari Elnaz , Gholizadeh Leila 
Published: November 2023

AbstractAimThis study aimed to determine factors associated with coping strategies used by nursing staff during the COVID‐19 pandemic in Iran.DesignCross‐sectional study.MethodsA convenience sample of 365 nurses were selected from referral hospitals for COVID‐19 patients in Tabriz, Iran between February 2022 and July 2022. An online self‐administered questionnaire was distributed through social media platforms, including WhatsApp and Instagram. The survey package included a modified Brief COPE scale, socio‐demographic and work‐related questions, and a measure of psychological distress. Multiple regression analysis examined associated factors with coping strategies in SPSS. The study adhered to the STROBE guidelines for reporting.ResultsThe mean age of participants was 31.2 (7.3) years old. Of the 365 participants, 209 (58.9%) used maladaptive coping strategies, and 214 (57.6%) reported experiencing psychological distress. Psychological distress was the strongest predictor of maladaptive coping strategies (β = 4.473, p < 0.001). Female nurses (β = 3.259, p < 0.05), nurses who were under 35 years of age (β = 3.214, p < 0.05), nurses with fewer than ten years of experience (β = 2.416, p < 0.001), those who worked in COVID‐19 ICUs (β = 4.321, p < 0.001), floor nurses (β = 2.344, p < 0.001), and those who worked two or more years in COVID‐19 settings (β = 3.293, p < 0.001) had higher mean scores in maladaptive coping strategies.Patient or Public ContributionNo patient or public contributions.