bluuebunny/crossref_metadata_2025_split huggingface dataset:
Trans‐Dioxidomolybdenum(VI) Porphyrins and their Catalytic Activity Mimicking Oxidative Bromination
Authors: Maurya Mannar R. , Prakash Ved , Sankar Muniappan 
Published: February 2024

AbstractSynthesis of trans‐dioxidomolybdenum(VI)‐meso‐tetraphenylporphyrin (trans‐[MoVIO2(TPP)], 1) and trans‐dioxidomolybdenum(VI)‐meso‐tetra(p‐chlorophenyl)porphyrin (trans‐[MoVIO2(TCPP)], 2) by reacting the corresponding free‐base porphyrins with Mo(CO)6 in 1,2,4‐trichlorobenzene at 190 °C has been reported. These are the second examples in the literature where molybdenum‐porphyrins have trans‐[MoVIO2] group, identified by single crystal X‐ray study. Both complexes have been utilized as functional model of haloperoxidases for the oxidative bromination of various phenol derivatives using KBr, H2O2 and HClO4 as green brominating reagents in aqueous medium. These complexes displayed very high TOF values (up to 16.2 s−1 for catalyst 2) representing excellent catalytic activity. To the best of our knowledge, this is the first report presenting trans‐dioxidomolybdenum(VI) based porphyrin as haloperoxidases mimicking oxidative bromination of various phenol derivatives.
Naturally occurring phytanic acid exerts anti‐inflammatory effects in a mouse model of dextran sulfate sodium‐induced colitis
Authors: Nakanishi Tomonori , Suga Keisuke , Wakitani Shoichi , Yamaguchi Kohta , Sugamoto Kazuhiro , Erickson Laurie , Kawahara Satoshi 
Published: February 2024

AbstractPhytanic acid is one of the branched‐chain fatty acids in the human diet. Humans incorporate it into their bodies through the ingestion of ruminant meat and milk since these animal products contain the 3RS, 7R, 11R‐isomer, as naturally occurring phytanic acid (nPA). Although phytanic acid has been reported to have health‐promoting effects such as immunomodulatory effects, these findings were obtained mostly from in vitro cell‐based experiments. In this study, the in vivo anti‐inflammatory effects of nPA were investigated using a mouse model of dextran sulfate sodium (DSS)‐induced colitis. Mice were fed diets containing 0%, 0.05%, or 0.1% nPA for 4 weeks. During the fourth week, acute colitis was induced by administration of a 3% DSS solution. The intake of 0.05% and 0.1% nPA inhibited DSS‐induced body weight loss in mice, and showed improvement of histopathological changes in colon epithelium. nPA also inhibited the production of proinflammatory cytokines, especially macrophage‐related cytokines such as interleukin‐1β in the colon. These results suggest that nPA exerts anti‐inflammatory effects under in vivo physiological conditions.Practical application: There is a growing demand for fatty acids possessing distinct nutritional and physical characteristics in the realms of health, nutrition, and food‐related applications. The present study demonstrated that a branched‐chain fatty acid, phytanic acid, exerts anti‐inflammatory activity under not only in vitro but also in vivo conditions, using a commonly used mouse model of human inflammatory bowel disease. Our findings encourage further studies to determine whether phytanic acid elicits beneficial properties in humans, and suggest that phytanic acid enrichment can be a novel product strategy in the food market.
Sampling design methods for making improved lake management decisions
Authors: Koski Vilja , Eidsvik Jo 
Published: February 2024

AbstractThe ecological status of lakes is important for understanding an ecosystem's biodiversity as well as for service water quality and policies related to land use and agricultural run‐off. If the status is weak, then decisions about management alternatives need to be made. We assess the value of information of lake monitoring in Finland, where lakes are abundant. With reasonable ecological values and restoration costs, the value of information analysis can be compared with the survey's costs. Data are worth gathering if the expected value from the data exceeds the costs. From existing data, we specify a hierarchical Bayesian spatial logistic regression model for the ecological status of lakes. We then rely on functional approximations and Laplace approximations to get closed‐form expressions for the value of information of a sampling design. The case study contains thousands of lakes. The combinatorially difficult design problem is to wisely pick the right subset of lakes for data gathering. To solve this optimization problem, we study the performance of various heuristics: greedy forward algorithms, exchange algorithms and Bayesian optimization approaches. The value of information increases quickly when adding lakes to a small design but then flattens out. Good designs are usually composed of lakes that are difficult to manage, while also balancing a variety of covariates and geographic coverage. The designs achieved by forward selection are reasonably good, but we can outperform them with the more nuanced search algorithms. Statistical designs clearly outperform other designs selected according to simpler criteria.
Study on the gas outburst control effect of goaf on the neighboring working face: Case study of Pingmei No.4 Mine
Authors: Shan Wenxuan , Chen Xuexi 
Published: February 2024

AbstractAs coal mining depth increases, there is a corresponding increase in both ground stress and gas pressure, leading to a higher incidence of coal and gas outburst accidents. To investigate the stress distribution law and gas release degree of the adjacent coal body within the goaf of the outburst coal seam, and to acquire an understanding of the impact range of the large mining face goaf on the stress of the coal seam, this study employed theoretical analysis and numerical simulation to analyze the impact and scope of the goaf on the adjacent coal body, and measured the gas content of the coal seam. The findings indicated that following the completion of mining on the working face, there was a redistribution of stress in the coal and rock layers within 40 m of the goaf, with the stress concentration phenomenon observed at a distance of 2.6 m from the goaf. Affected by the stress relief effect of mining, the stress, gas content, and other related factors have been studied in detail by researchers. Affected by the stress relief effect of mining, the stress, gas content, and gas pressure of the surrounding rock near the goaf in the coal seam are significantly reduced. The research results verify that tunneling along the goaf is an effective method to prevent coal and gas outbursts and improve stoping efficiency.
What have I done for the cause today? Evaluators, evaluation, and CREA
Authors: Neubauer Leah C. , Boyce Ayesha S. , Bowman Nicole R. 
Published: February 2024

AbstractThis article considers the volume's intentions, process, and gaps while inviting attention to the impact and influence of CREA and Dr. Hood on evaluators and evaluation. Three of the co‐editors author this conclusion by revisiting the key questions and drawing connections between the positions and statements advocated by the contributing authors. The final editor offers final thoughts in the epilogue. CRE is a community, grassroots, and international movement; readers are invited to consider how integrity, courage, and action exist in their everyday evaluation practice.
Cornea‐SELEX for aptamers targeting the surface of eyes and liposomal drug delivery
Authors: Wong Ka‐Ying , Liu Yibo , Wong Man‐Sau , Liu Juewen 
Published: February 2024

AbstractCornea is the major barrier to drug delivery to the eye, which results in low bioavailability and poor efficacy of topical eye treatment. In this work, we first select cornea‐binding aptamers using tissue‐SELEX on pig cornea. The top two abundant aptamers, Cornea‐S1 and Cornea‐S2, could bind to pig cornea, and their Kd values to human corneal epithelial cells (HCECs) were 361 and 174 nм, respectively. Aptamer‐functionalized liposomes loaded with cyclosporine A (CsA) were developed as a treatment for dry eye diseases. The Kd of Cornea‐S1‐ or Cornea‐S2‐functionalized liposomes reduces to 1.2 and 15.1 nм, respectively, due to polyvalent binding. In HCECs, Cornea‐S1 or Cornea‐S2 enhanced liposome uptake within 15 min and extended retention to 24 h. Aptamer CsA liposomes achieved similar anti‐inflammatory and tight junction modulation effects with ten times less CsA than a free drug. In a rabbit dry eye disease model, Cornea‐S1 CsA liposomes demonstrated equivalence in sustaining corneal integrity and tear break‐up time when compared to commercial CsA eye drops while utilizing a lower dosage of CsA. The aptamers obtained from cornea‐SELEX can serve as a general ligand for ocular drug delivery, suggesting a promising avenue for the treatment of various eye diseases and even other diseases.
Endoperoxide‐enhanced self‐assembled ROS producer as intracellular prodrugs for tumor chemotherapy and chemodynamic therapy
Authors: Tang JunJie , Liu Yadong , Xue Yifan , Jiang Zhaozhong , Chen Baizhu , Liu Jie 
Published: February 2024

AbstractProdrug‐based self‐assembled nanoparticles (PSNs) with tailored responses to tumor microenvironments show a significant promise for chemodynamic therapy (CDT) by generating highly toxic reactive oxygen species (ROS). However, the insufficient level of intracellular ROS and the limited drug accumulation remain major challenges for further clinical transformation. In this study, the PSNs for the delivery of artesunate (ARS) are demonstrated by designing the pH‐responsive ARS‐4‐hydroxybenzoyl hydrazide (HBZ)‐5‐amino levulinic acid (ALA) nanoparticles (AHA NPs) with self‐supplied ROS for excellent chemotherapy and CDT. The PSNs greatly improved the loading capacity of artesunate and the ROS generation from endoperoxide bridge using the electron withdrawing group attached directly to C10 site of artesunate. The ALA and ARS‐HBZ could be released from AHA NPs under the cleavage of hydrazone bonds triggered by the acidic surroundings. Besides, the ALA increased the intracellular level of heme in mitochondria, further promoting the ROS generation and lipid peroxidation with ARS‐HBZ for excellent anti‐tumor effects. Our study improved the chemotherapy of ARS through the chemical modification, pointing out the potential applications in the clinical fields.
A sharp immersed method for electrohydrodynamic flows accompanied by charge evaporation
Authors: Chen Chong , Lu Chang , Xia Guangqing , Chen Maolin , Sun Bin 
Published: February 2024

AbstractThis article presents a sharp immersed method for simulating electrohydrodynamic (EHD) flows that involve charge evaporation. This well‐known multi‐scale, multi‐physics problem is widely used in various fields, including industry and medicine. The method adopts a fully sharp model, where surface tension and Maxwell stress are treated as surface forces and free charges are concentrated on the zero thickness liquid‐vacuum interface. Incorporating charge evaporation imposes strict restrictions on the time‐step, as the rate of evaporation sharply increases with surface evolution. To overcome this challenge, an iterative algorithm that couples the electric field and surface charge density is proposed to obtain accurate results, even with significantly large time‐steps. To mitigate the numerical residuals near the interface, which may introduce parasitic flows and cause numerical instability, an immersed interface method‐based iterative projection method for the Navier–Stokes equations is proposed, in which a traction boundary condition involving multiple surface forces is imposed on the sharp interface. Numerical experiments were carried out, and the results show that the method is splitting‐error‐free and stable. The sharp immersed method is applied to simulate the electric‐induced deformation of an ionic liquid drop with charge evaporation. The results indicate that charge evaporation can suppress the sharp development of Taylor cones at the ends of the drops. These findings have significant implications for the design and optimization of EHD systems in various applications.
Making sense of breast cancer risk estimates
Authors: O'Quigley John 
Published: February 2024

AbstractIndividual probabilistic assessments on the risk of cancer, primary or secondary, will not be understood by most patients. That is the essence of our arguments in this paper. Greater understanding can be achieved by extensive, intensive, and detailed counseling. But since probability itself is a concept that easily escapes our everyday intuition—consider the famous Monte Hall paradox—then it would also be wise to advise patients and potential patients, to not put undue weight on any probabilistic assessment. Such assessments can be of value to the epidemiologist in the investigation of different potential etiologies describing cancer evolution or to the clinical trialist as a way to maximize design efficiency. But to an ordinary individual we cannot anticipate that these assessments will be correctly interpreted.
Age‐related changes in root dynamics of a novel perennial grain crop
Authors: Woeltjen Stella , Gutknecht Jessica , Jungers Jacob 
Published: February 2024

AbstractBackgroundStanding root biomass stocks are larger in the perennial grain intermediate wheatgrass (IWG; Thinopyrum intermedium [Host] Barkworth and Dewey) than annual spring wheat (Triticum aestivum L.). However, previous studies have not separated root growth from root decomposition, which presents a significant gap in our understanding of how roots can contribute to soil organic carbon (C) accrual or other soil properties through time.MethodsWe used paired sequential coring and root ingrowth cores to measure standing root stock, new root production, root decomposition, and decomposed root C and N from 0 to 15 cm soil depth of 1‐year‐old IWG (IWG‐1), 2‐year‐old IWG (IWG‐2), and annual spring wheat.ResultsStanding root stock was 3.2–6.5 and 6.3–9.9 times higher in IWG‐1 and IWG‐2 than wheat. Total root production was 1.7 times greater in IWG‐1 than IWG‐2. Conversely, root decomposition almost doubled from 1.39 to 2.43 kg m−3 between IWG‐1 and IWG‐2.ConclusionsIn IWG, decreased root production and increased root decomposition with stand age suggest a change in growth strategy that could reduce the contribution of root‐derived C to stabilized soil C pools as IWG stands age.
Re‐emergence of polio in Pakistan: Can the nation achieve the WPV1 eradication goal?
Authors: Faizan Aqib , Rehman Tooba , Mughal Sanila 
Published: February 2024

AbstractBackground and AimsPoliomyelitis is an acute neurologic condition that causes muscle weakness, permanent flaccid paralysis, and even death. The world has seen a drastic fall in the number of poliovirus cases owing to effective immunization programs and preventive measures. Pakistan and Afghanistan still remain the two endemic countries for poliovirus, particularly, the WPV1 strain. Global Polio Eradication Initiative (GPEI) has set a target to eradicate all WPV1 cases by the end of 2023. However, the re‐emergence of WPV1 cases has posed a serious setback for the achievement of this target. This article aims to discuss the public health challenges that contribute to resurgence of poliovirus cases.MethodsA comprehensive literature search was conducted using various databases including Cochrane, Google Scholar, PubMed, Science Direct, MEDLINE. Only articles written in English were considered. All the articles reporting the incidence of poliovirus and WPV1 cases in Pakistan, surveillance data and global context of poliovirus outbreak were evaluated to write this correspondence. In addition, references from the selected articles were also examined to ensure a comprehensive review of the literature.ResultsThis article highlights the factors contributing to the re‐emergence of WPV1 cases in Pakistan. Low vaccine coverage, attacks on frontline polio health workers, misinformation, and reluctance to vaccine acceptance pose a daunting challenge for polio eradication. Further, gaps in AFP surveillance and sensitivity may underestimate the true extent of the emerging genetic clusters. The Covid‐19 pandemic and subsequent flooding in the affected area have further worsened the underdeveloped public health infrastructure.ConclusionDespite the challenges, the country has observed a significant decline in the number of cases in the past 2 years. It is high time to capitalize on the decrease in WPV1 cases by intensifying the efforts to mitigate and limit the spread of the disease.
Modeling heat transfer and air circulation by convection in bottom‐heated agricultural greenhouses
Authors: Hssain Mustapha Ait , Armou Sara , Nouari Soufiane , Mir Rachid 
Published: February 2024

AbstractIn agricultural greenhouses, effective heating systems are essential for maintaining proper temperature control and air circulation during the winter. This study delves into the analysis of heat exchange through natural convection within heated greenhouses, with a particular emphasis on the impact of bottom heating. Two distinct types: mono‐chapel and bi‐chapel, each featuring triangular or spherical roofs are examined. To capture the variable roof shapes, we employ a change‐of‐variable method, and the numerical solutions are obtained using the finite volume method. The results show that heat transfer is enhanced by increasing the Rayleigh number. This improvement differs according to the shape of the roof. Heat transfer decreases by about 5% for the spherical mono‐chapel case compared to the triangular case for Ra = 103. For Ra = 105, the monospherical case favors heat transfer, with an increase of 0.35% compared to the triangular case. In the case of bi‐chapel roof, heat transfer is greater with a triangular roof for Ra = 103, showing an increase of 6.4% compared to the spherical case. This study not only sheds light on the fundamental aspects of heat transfer in greenhouses but also provides valuable insights for optimizing greenhouse design based on specific roof configurations and heating conditions.
Impact of climate change on the future distribution of three Ferulago species in Iran using the MaxEnt model
Authors: Hosseini Naser , Mostafavi Hossein , Sadeghi Seyed Mohammad Moein 
Published: February 2024

Abstract
The decline of habitats supporting medicinal plants is a consequence of climate change and human activities. In the Middle East, Ferulago angulata, Ferulago carduchorum, and Ferulago phialocarpa are widely recognized for their culinary, medicinal, and economic value. Therefore, this study models these Ferulago species in Iran using the MaxEnt model under two representative concentration pathways (RCP4.5 and RCP8.5) for 2050 and 2070. The objective was to identify the most important bioclimatic (n = 6), edaphic (n = 4), and topographic (n = 3) variables influencing their distribution and predict changes under various climate scenarios. Findings reveal slope percentage as the most significant variable for F. angulata and F. carduchorum, while solar radiation was the primary variable for F. phialocarpa. MaxEnt modeling demonstrated good to excellent performance, as indicated by all the area under the curve values exceeding 0.85. Projections suggest negative area changes for F. angulata and F. carduchorum (i.e., predictions under RCP4.5 for 2050 and 2070 indicate −34.0% and −37.8% for F. phialocarpa, and −0.3% and −6.2% for F. carduchorum; additionally, predictions under RCP 8.5 for 2050 and 2070 show −39.0% and −52.2% for F. phialocarpa, and −1.33% and −9.8% for F. carduchorum), while for F. phialocarpa, a potential habitat increase (i.e., predictions under RCP4.5 for 2050 and 2070 are 23.4% and 11.2%, and under RCP 8.5 for 2050 and 2070 are 64.4% and 42.1%) is anticipated. These insights guide adaptive management strategies, emphasizing conservation and sustainable use amid global climate change. Special attention should be paid to F. angulata and F. carduchorum due to anticipated habitat loss. Integr Environ Assess Manag 2024;20:1046–1059. © 2024 SETAC
Key Points
This national study on Ferulago species reveals a substantial decline in medicinal plant habitats triggered by climate change. For Ferulago angulata and Ferulago carduchorum, slope percentage emerges as the pivotal variable, while solar radiation takes precedence for Ferulago phialocarpa. MaxEnt modeling demonstrated robust performance, with all area under the curve values exceeding 0.85, ensuring reliable predictions. Projections suggest negative area changes for F. angulata and F. carduchorum, emphasizing potential habitat loss, while for F. phialocarpa a habitat increase is anticipated, providing valuable insights for adaptive management strategies amid global climate change.
Changes in mortality associated with different hematologic malignancies during the pandemic in the United States
Authors: Fedeli Ugo , Barbiellini Amidei Claudio , Han Xuesong , Jemal Ahmedin 
Published: February 2024

AbstractPatients with hematologic malignancies are at increased risk of adverse COVID‐19 outcomes; nonetheless, only sparse population‐based data are available on mortality related to hematologic cancers during the pandemic. Number of deaths and age‐standardized mortality rates for specific hematologic malignancies selected either as the underlying cause of death (UCOD), or mentioned in death certificates (multiple causes of death‐MCOD) were extracted from the US National Center for Health Statistics, CDC WONDER Online Database. Joinpoint analysis was applied to identify changes in mortality trends from 1999 to 2021, and to estimate the annual percent change with 95% Confidence Intervals (CI) across time segments. Among the most common malignancies, chronic lymphocytic leukemia showed marked peaks in the monthly number of deaths attributed to COVID‐19 during epidemic waves; acute myeloid leukemia showed the least variation, and non‐Hodgkin lymphoma and multiple myeloma were characterized by an intermediate pattern. Age‐standardized death rates relying solely on the UCOD did not show significant variations during pandemic years. By contrast, rates based on MCOD increased by 14.0% (CI, 10.2–17.9%) per year for chronic lymphocytic leukemia, by 5.1% (CI, 3.1–7.2%) for non‐Hodgkin lymphoma and by 3.2% (CI, 0.3–6.1%) per year for multiple myeloma. Surveillance of mortality based on MCOD is warranted to accurately measure the impact of the COVID‐19 pandemic and of other epidemics, including seasonal flu, on patients with hematologic malignancies, and to assess the effects of vaccination campaigns and other preventive measures.