bluuebunny/crossref_metadata_2025_split huggingface dataset:
Directional Charge Pumping from Photoactive P‐doped CdS to Catalytic Active Ni2P via Funneled Bandgap and Bridged Interface for Greatly Enhanced Photocatalytic H2 Evolution
Authors: Chen Aizhu , Yang Xuhui , Shen Lijuan , Zheng Ying , Yang Min‐Quan 
Published: January 2024

AbstractLoading cocatalysts onto semiconductors is one of the most popular strategies to inhibit charge recombination, but the efficiency is generally hindered by the localized built‐in electric field and the weakly connected interface. Here, this work designs and synthesizes a 1D P‐doped CdS nanowire/Ni2P heterojunction with gradient doped P to address the challenges. In the composite, the gradient P doping not only creates a funneled bandgap structure with a built‐in electric field oriented from the bulk of P‐CdS to the surface, but also facilitates the formation of a tightly connected interface using the co‐shared P element. Consequently, the photogenerated charge carriers are enabled to be pumped from inside to surface of the P‐CdS and then smoothly across the interface to the Ni2P. The as‐obtained P‐CdS/Ni2P displays high visible‐light‐driven H2 evolution rate of ≈8265 µmol g−1 h−1, which is 336 times and 120 times as that of CdS and P‐CdS, respectively. This work is anticipated to inspire more research attention for designing new gradient‐doped semiconductor/cocatalyst heterojunction photocatalysts with bridged interface for efficient solar energy conversion.
Emergence and impact of theranostic‐nanoformulation of triple therapeutics for combination cancer therapy
Authors: Rajora Amit Kumar , Ahire Eknath D. , Rajora Manju , Singh Sukhvir , Bhattacharya Jaydeep , Zhang Hongbo 
Published: January 2024

AbstractCancer remains a major global health threat necessitating the multipronged approaches for its prevention and management. Traditional approaches in the form of chemotherapy, surgery, and radiotherapy are often encountered with poor patient outcomes evidenced by high mortality and morbidity, compelling the need for precision medicine for cancer patients to enable personalized and targeted cancer treatment. There has been an emergence of smart multimodal theranostic nanoformulation for triple combination cancer therapy in the last few years, which dramatically enhances the overall safety of the nanoformulation for in vivo and potential clinical applications with minimal toxicity. However, it is imperative to gain insight into the limitations of this system in terms of clinical translation, cost‐effectiveness, accessibility, and multidisciplinary collaboration. This review paper aims to highlight and compare the impact of the recent theranostic nanoformulations of triple therapeutics in a single nanocarrier for effective management of cancer and provide a new dimension for diagnostic and treatment simultaneously.
Economic freedom and growth, income, investment, and inequality: A quantitative summary of the literature
Authors: Lawson Robert , Miozzi Vincent , Tuszynski Meg 
Published: January 2024

AbstractThis study examines the published estimates on the relationship between economic freedom, as measured by the Economic Freedom of the World (EFW) index, and measures of growth, income, investment, and inequality. We obtained 696 point estimates for economic freedom‐growth from 54 articles, 386 estimates for economic freedom‐income from 23 articles, 343 estimates for economic freedom‐investment from 32 articles, and 759 estimates for economic freedom‐inequality from 26 articles. The published estimates support the view that economic freedom is positively related to growth, income, and investment. The level of economic freedom appears to be simply unrelated to inequality, though increases in economic freedom may correlate with higher inequality.
Clinical prognostication and immunotherapy response prediction in esophageal squamous cell carcinoma using the DNA damage repair‐associated signature
Authors: Zhang Pengpeng , Wen Bing , Gong Jialin , Liu Zuo , Zhang Mengzhe , Zhou Guangyao , Zhang Lianmin , Zhang Zhenfa 
Published: January 2024

AbstractBackgroundThe relationship between DNA damage repair (DDR) and cancer is intricately intertwined; however, its specific role in esophageal squamous cell carcinoma (ESCC) remains enigmatic.MethodsEmploying single‐cell analysis, we delineated the functionality of DDR‐related genes within the tumor microenvironment (TME). A diverse array of scoring mechanisms, including AUCell, UCell, singscore, ssgsea, and AddModuleScore, were harnessed to scrutinize the activity of DDR‐related genes across different cell types. Differential pathway alterations between high‐and low‐DDR activity cell clusters were compared. Furthermore, leveraging multiple RNA‐seq datasets, we constructed a robust DDR‐associated signature (DAS), and through integrative multiomics analysis, we explored differences in prognosis, pathways, mutational landscapes, and immunotherapy predictions among distinct DAS groups.ResultsNotably, high‐DDR activity cell subpopulations exhibited markedly enhanced cellular communication. The DAS demonstrated uniformity across multiple datasets. The low‐DAS group exhibited improved prognoses, accompanied by heightened immune infiltration and elevated immune checkpoint expression. SubMap analysis of multiple immunotherapy datasets suggested that low‐DAS group may experience enhanced immunotherapy responses. The “oncopredict” R package analyzed and screened sensitive drugs for different DAS groups.ConclusionThrough the integration of single‐cell and bulk RNA‐seq data, we have developed a DAS associated with prognosis and immunotherapy response. This signature holds promise for the future stratification and personalized treatment of ESCC patients in clinical settings.
Unlocking solutions for cleaner waters: The Industrial Wastewater Quality Index in Egypt and beyond
Authors: M. Salman Abdou Doaa , el Ragehy Eid 
Published: January 2024

AbstractThis research study conducted in Egypt focuses on addressing the issue of industrial water pollution and promoting sustainable water and environmental management practices. The study introduces a novel tool called the Industrial Wastewater Quality Index (IWQI) and utilizes two assessment methods to evaluate the extent of water pollution caused by industrial effluents. The IWQI takes into consideration both the environmental limits specified by Egyptian legislation and industry‐specific parameters, effectively condensing extensive water quality data into simplified categories. The IWQI model proves to be a dependable instrument for assessing the overall quality of groundwater intended for industrial use. It incorporates multiple water quality indices and employs multivariate statistical analysis techniques to determine the contribution of each parameter to industrial water quality. This comprehensive analysis enhances the reliability of the model, making it a valuable point of reference for similar locations worldwide, particularly those sharing similar climatic conditions. The outcomes of this study provide valuable insights for policymakers and stakeholders involved in regulating and mitigating industrial water pollution in Egypt. The findings also have relevance to other countries facing similar challenges, highlighting the importance of developing effective techniques for investigating pollution sources, monitoring water quality, and forecasting future trends. The study underscores the necessity of implementing proactive measures to address industrial water pollution and protect water resources and ecosystems. By emphasizing these aspects, the study emphasizes the importance of promoting sustainable water and environmental management practices. Overall, the IWQI and the study's findings contribute to the development of strategies to manage and control industrial water pollution and can guide policymakers and stakeholders in Egypt and other countries facing similar challenges.
The Limits of Luc Besson’s ‘Made-in-France’ Blockbusters: From the Transnational to the Postnational in Valerian and Anna
Authors: Vanderschelden Isabelle 
Published: January 2024

AbstractBy creating EuropaCorp in 2000, Luc Besson provided an alternative model to Hollywood studio cinema that could compete in the globalised markets of the new millennium. The chapter discusses how his latest productions, Valerian and the City of the Thousand Planets (Besson, 2017) and Anna (Besson, 2019), French films shot in English with non-French casts, try to renegotiate transnational and postnational features but fail to consolidate his model of global popular filmmaking made in France. It argues that after the global success of Lucy (Besson, 2014) had revived the potential of the EuropaCorp transnational production model, Valerian and Anna have shown the limits of Besson’s brand and filmmaking methods. It also identifies reasons behind their mixed reception and links their disappointing results to the implosion of EuropaCorp in 2020.
Whose Lost Bullet? Netflix, Cultural Politics and the Branding of French Action Cinema
Authors: Michael Charlie 
Published: January 2024

AbstractThe recent appearance of French-language action films on Netflix should be seen as an extension of industrial reforms of the 1990s and 2000s, when action cinema—historically neglected in France—found a home at studios like StudioCanal and EuropaCorp. Netflix has expanded that game, producing and acquiring a flurry of Franco-European content while making its ‘stack’ menus host to a new, sliding game of cultural and generic indexing. Using the recent Netflix film Lost Bullet (Pierret, 2020) as a case study, this chapter proposes a schema for thinking through how postnational French popular culture combines North American genre conventions with Franco-European cultural inputs.
Charlotte Rampling Made in France: From a National to a Postnational Identity
Authors: Le Gras Gwénaëlle 
Published: January 2024

AbstractBy examining the recent career steps of Charlotte Rampling, this chapter questions the evolution of her real and imaginary identity fluidity, which is based on a variable articulation between constructions of the national, the international and the global. Although the actress’s spoken accent maintains the trace of her English origins, three facts blur the sharpness of this identity. Rampling has systematically dubbed herself in English as well as in French, creating an intercultural fluidity; she has revived and intensified her ability to express the interiority of her characters through the universal language of silence; and finally her characters are alternately English, integrated into a French collective while her own identity remains vague; or, in French co-productions that mark a new trend within her filmography, postnationally indexed and inflected.
National and Postnational Femininity in Engrenages: The Limits of Empowerment
Authors: Vincendeau Ginette 
Published: January 2024

AbstractThe French police series Engrenages/Spiral (eight seasons, 2005–2020) achieved international recognition for its ‘gritty’ realism, its attention to the idiosyncrasies of the French criminal justice system and especially for featuring women in the two lead roles: detective Laure Berthaud (Caroline Proust) and lawyer Joséphine Karlsson (Audrey Fleurot). This chapter explores the two women’s contrasting trajectories, their different attitudes to work ethics and sexuality and the inscription of bodily trauma (motherhood for Laure, rape for Joséphine) on their screen identities. The analysis demonstrates that despite their ostensibly empowered roles, the two female protagonists embody conservative concepts of femininity. It is argued that this sexual stereotyping, alongside a lack of racial diversity, ultimately maintains the series within a national tradition and has limited its postnational reach.
Migration Status, Class, Race and Home
Authors: Fathi Mastoureh , Ní Laoire Caitríona 
Published: January 2024

AbstractMigration regimes are powerful forces that allow or deny individuals, in different ways, the possibilities of feeling at home, imagining home or doing home. This chapter draws on existing literature to show how migrant status, class and race intersect not only with each other but with gender, age, and other power relations in structuring these im/possibilities through bordering processes linked to global geopolitical and postcolonial processes. Firstly, the chapter explores how privileged migrant groups can draw on their available capital to reproduce comfortable notions of home in migration, and how different migration/citizenship regimes enable this. Secondly, the focus is brought to the phenomenon of enforcement, precarity and stuckness in migration, as a lens through which to explore how migrant status, class and race limit the possibilities of feeling at home for other migrant groups and how they navigate these limitations and borders in seeking to find and make home in the world.
A novel aminopeptidase N/CD13 inhibitor selectively targets an endothelial form of CD13 after coupling to proteins
Authors: Anderluzzi Giulia , Ghitti Michela , Gasparri Anna Maria , Taiè Giulia , Sacchi Angelina , Gori Alessandro , Andolfo Annapaola , Pozzi Federica , Musco Giovanna , Curnis Flavio , Corti Angelo 
Published: January 2024

AbstractAminopeptidase N/CD13, a membrane-bound enzyme upregulated in tumor vasculature and involved in angiogenesis, can be used as a receptor for the targeted delivery of drugs to tumors through ligand-directed targeting approaches. We describe a novel peptide ligand (VGCARRYCS, called “G4”) that recognizes CD13 with high affinity and selectivity. Enzymological and computational studies showed that G4 is a competitive inhibitor that binds to the catalytic pocket of CD13 through its N-terminal region. Fusing the peptide C-terminus to tumor necrosis factor-alpha (TNF) or coupling it to a biotin/avidin complex causes loss of binding and inhibitory activity against different forms of CD13, including natural or recombinant ectoenzyme and a membrane form expressed by HL60 promyelocytic leukemia cells (likely due to steric hindrance), but not binding to a membrane form of CD13 expressed by endothelial cells (ECs). Furthermore, G4-TNF systemically administered to tumor-bearing mice exerted anticancer effects through a CD13-targeting mechanism, indicating the presence of a CD13 form in tumor vessels with an accessible binding site. Biochemical studies showed that most CD13 molecules expressed on the surface of ECs are catalytically inactive. Other functional assays showed that these molecules can promote endothelial cell adhesion to plates coated with G4-avidin complexes, suggesting that the endothelial form of CD13 can exert catalytically independent biological functions. In conclusion, ECs express a catalytically inactive form of CD13 characterized by an accessible conformation that can be selectively targeted by G4-protein conjugates. This form of CD13 may represent a specific target receptor for ligand-directed targeted delivery of therapeutics to tumors.
Mental health is strongly associated with capability after lower extremity injury treated with free flap limb salvage or amputation
Authors: Krijgh David D. , Teunis Teun , List Emile B. , Mureau Marc A. M. , Luijsterburg Antonius J. M. , Maarse Wiesje , Schellekens Pascal P. A. , Hietbrink Falco , de Jong Tim , Coert J. Henk 
Published: January 2024

Abstract
Background
Knowledge about factors associated with long-term outcomes, after severe traumatic injury to the lower extremity, can aid with the difficult decision whether to salvage or amputate the leg and improve outcome. We therefore studied factors independently associated with capability at a minimum of 1 year after amputation or free flap limb salvage.

Methods
We included 135 subjects with a free flap lower extremity reconstruction and 41 subjects with amputation, between 1991 and 2021 at two urban-level 1 trauma centers with a mean follow-up of 11 ± 7 years. Long-term physical functioning was assessed using the Physical Component Score (PCS) of the Short-Form 36 (SF36) and the Lower Extremity Functional Scale (LEFS) questionnaires. Independent variables included demographics, injury characteristics, and the Mental Component Score (MCS) of the SF36.

Results
Greater mental health was independently and strongly associated with greater capability, independent of amputation or limb reconstruction. Mental health explained 33% of the variation in PCS and 57% of the variation in LEFS. Injury location at the knee or leg was associated with greater capability, compared to the foot or ankle. Amputation or limb reconstruction was not associated with capability.

Discussion
This study adds to the growing body of knowledge that physical health is best regarded through the lens of the bio-psycho-social model in which mental health is a strong determinant. This study supports making mental health an important aspect of rehabilitation after major lower extremity injury, regardless of amputation or limb salvage.
Soziale Ungleichheit im Zusammenhang mit digitalen Gesundheitsanwendungen: Digitale Spaltungen in den Bereichen Zugang, Nutzung, Wirksamkeit und Privatsphäre
Authors: Brand Tilman , Herrera-Espejel Paula , Muellmann Saskia , Wiersing Rebekka , Busse Heide 
Published: January 2024

ZusammenfassungIn Anbetracht der Zunahme an digitalen Gesundheitsangeboten drängt sich die Frage auf, welche Folgen sich daraus für die gesundheitliche Chancengleichheit ergeben. Ziel dieses narrativen Übersichtsbeitrages ist es, das Ausmaß und die zentralen Aspekte der digitalen Spaltungen (Digital Divide) zu diskutieren. Zur Illustration des Ausmaßes der digitalen Spaltungen wird auf Daten der Liter@te-Studie zurückgegriffen, in der Personen mit einer geringen Literalität (geringe Lese- und Schreibkompetenzen) zur Nutzung von digitalen Gesundheitsangeboten und zu ihrer digitalen Gesundheitskompetenz befragt wurden. Die Ergebnisse der Liter@te-Studie werden mit parallel durchgeführten Bevölkerungsumfragen verglichen. In Bezug auf digitale Spaltungen lassen sich 4 Bereiche unterscheiden: Zugang, Nutzung, Wirksamkeit und Schutz der Privatsphäre. In allen 4 Bereichen lassen sich Ungleichheiten beobachten. Während Unterschiede im Zugang bzw. in der materiellen Infrastruktur sowie im Nutzungsverhalten und in der dafür notwendigen Kompetenz bereits in einigen Studien untersucht wurden, fehlt für eine umfassende Bewertung der ungleichen Wirkungen von digitalen Gesundheitsangeboten in verschiedenen Bevölkerungsgruppen noch die Datengrundlage. Digitale Spaltungen im Bereich des Schutzes der Privatsphäre sind bisher noch wenig untersucht. Transparente und verständliche Datenschutzmaßnahmen werden jedoch zweifelsohne eine wichtige Voraussetzung für den flächendeckenden Einsatz von digitalen Gesundheitsangeboten sein. Insgesamt ist neben einer besseren Studienlage auch eine stärkere Einbeziehung von benachteiligten Adressatengruppen in die Entwicklung von digitalen Gesundheitsangeboten notwendig.
Konzept und Umsetzung eines adaptiven digitalen Hörtrainingssystems für die Cochlea-Implantatnachsorge
Authors: Werminghaus Maika , Gnadlinger Florian , Richter Jutta G. , Selmanagić André , Thyson Susann , Schatton Dorothee , Klenzner Thomas 
Published: January 2024

Zusammenfassung
Hintergrund und Ziel
Im Rahmen eines interdisziplinären Forschungsprojekts wurde ein Prototyp eines adaptiven, digitalen Hörtrainingssystems für Cochlea-Implantat(CI)-Nutzende entwickelt. Die Autoren integrierten eine dynamische Schwierigkeitsanpassung in Abhängigkeit von der individuellen Leistung des Nutzenden unter Verwendung des „Evidence-Centered-Design(ECD)-Frameworks“.

Methoden
Das ECD bietet einen konzeptionellen Gestaltungsrahmen, der sich für komplexe Beurteilungen von Kompetenzen und dynamischen Leistungen eignet. In der Findungsphase wurden zunächst die Teilbereiche des Hörens im Kontext von CI-Nutzenden definiert. In der Entwicklungsphase wurden das im ECD vorgesehene Kompetenzmodell, das Evidenzmodell sowie ein Aufgabenmodell entwickelt und implementiert. Zusätzlich wurde ein Assetpool mit Sound- und Sprachdateien angelegt, der umfassende linguistische Merkmalsbeschreibungen zur Berechnung der Itemschwierigkeiten beinhaltete.

Ergebnisse
Aufgrund der beschriebenen Anforderungen wurden ein adaptiver Übungsgenerator, ein Künstlicher-Intelligenz(KI)-Service sowie weitere Komponenten implementiert. Dies umfasste die Entwicklung eines Spielumfelds und eines Dashboards für das Patientendatenmanagement. Für die Berechnung des Schwierigkeitsgrads der Übungen wurden die Itemschwierigkeiten anhand verschiedener Parameter (z. B. Klang, Worthäufigkeit und Anzahl der Wörter, grammatische Eigenschaften) in Kombination mit definierten Aufgabentypen und -leveln bestimmt.

Schlussfolgerung
Die Nachsorge von CI-Patienten kann durch ein adaptives digitales Hörtrainingssystem in einem kontinuierlichen, interaktiven Prozess unter Berücksichtigung individueller Bedürfnisse gewinnbringend erweitert werden. Die Autoren sehen das ECD als einen effektiven Weg, ein benutzerbasiertes, anpassungsfähiges System aufzubauen.
Artists or art thieves? media use, media messages, and public opinion about artificial intelligence image generators
Authors: Brewer Paul R. , Cuddy Liam , Dawson Wyatt , Stise Robert 
Published: January 2024

Abstract
This study investigates how patterns of media use and exposure to media messages are related to attitudes about artificial intelligence (AI) image generators. In doing so, it builds on theoretical accounts of media framing and public opinion about science and technology topics, including AI. The analyses draw on data from a survey of the US public (N = 1,035) that included an experimental manipulation of exposure to tweets framing AI image generators in terms of real art, artists’ concerns, artists’ outrage, or competing interpretations. The results show that technology news use and science fiction viewing predicted support for AI art but also predicted belief that AI image generators will take jobs and steal art styles from human artists. In addition, the experimental results demonstrate that exposure to specific media messages can influence these responses. The findings carry implications for understanding the future adoption, use, and regulation of AI image generators.