bluuebunny/crossref_metadata_2025_split huggingface dataset:
Comparación Del Entrenamiento Con Sobrecargas Isoinerciles Contra Convencionales En Patinadores De Carreras De La Liga De Norte De Santander
Authors: Lozano Zapata Rafael Enrique , Peñaloza Sarabia Jhon Paul 
Published: December 2023

Los entrenamientos con sobrecarga isoinerciales se hacen cada vez más populares entre los tipos de entrenamiento que se pueden realizar con los deportistas, de esta manera optimizar su rendimiento, esto con base a la fuerza como una condición muy importante para la competición, al momento de realizar la técnica deportiva de forma eficiente, por ello, es indispensable saber qué tipo de entrenamiento es más eficaz a la hora de entrenar, lo cual generó el objetivo ¨Comparar los entrenamientos con sobrecargas isoinerciales contra convencionales¨. La investigación fue descriptiva cuasi experimental con una duración de 10 semanas y una intervención de 5 días por semana, ya que compara datos de pre-test y post-test. Se conocieron las variables como el test de fuerza (1RM) y test de potencia miembros inferiores (Bosco); algunos resultados relevantes encontrados con la muestra de 26 patinadores, 8 hombres y 18 mujeres con edades comprendidas 15 ± 1,69 años, en la potencia de miembros inferiores del test de Bosco el grupo control hombres tuvieron un promedio en pre-test de 81,84±3,9 kgm/seg y post test de 82,05±1,5 kgm/seg – grupo control mujeres pre test de 65,81±2,5 kgm/seg y post test de 70,73±2,1, mientras que el grupo experimental hombres pre test de 70,27± 1,8 en post test 76,56± 3,4 - mujeres experimental pre test 61,65± 1,8 post-test 68,81±2,21; En el test de 1RM el grupo control hombres tuvieron un promedio en pre-test de 97,5±14,79kg en post test 103,70± 15,6 kg, mientras que el grupo experimental hombres 77,5±25,8 kg en post test 95,89± 26,6 kg, se observa que en grupo experimental obtuvo mayores resultados en cuando a la ganancia de potencia y fuerza esto en sus miembros inferiores, usando el novedoso método de la maquina con sobrecargas isoinercial, concluyendo, los entrenamientos con carga de uso isoinercial revelan mayores beneficios en comparación con los entrenamientos con maquina convencionales, por lo tanto los entrenamiento excéntricos nos indica un buen predictor de la condición física y representa tener mejores resultados.
A novel technique for successful closed reduction of a lisfranc fracture-dislocation
Authors: Henry James P , Discala Nicholas , Rizzo Sarah E , Bitterman Adam D 
Published: December 2023

The purpose of this study is to present a novel technique for the closed reduction of a divergent Lisfranc fracture-dislocation. Successful closed reduction of this injury limits the morbidity associated with soft tissue compromise that may otherwise delay definitive surgical fixation. A combination of weighted axial traction/counter-traction with a two-stage manipulation of the medial/middle and middle/lateral columns of the mid- and forefoot was performed. A Kling was affixed to the hallux and second ray within closed loops, then mounted to an intravenous pole. Weight was then applied to the distal tibia. Axial traction-counter traction and manual plantar translation with medial to lateral compression were then combined until successful reduction of the first and second metatarsal was achieved. The third, fourth and fifth metatarsals were hyper-dorsiflexed and abducted with subsequent inline manual traction and lateral to medial compression over the base of the metatarsals. This was followed by plantarflexion and adduction to complete the reduction maneuver. : A combination of weighted axial traction/counter-traction with two-stage manipulation of the medial/middle and middle/lateral columns of the mid- and forefoot was performed to successfully reduce a divergent Lisfranc fracture-dislocation. Successful closed reduction avoided the need for acute open reduction and mitigated the risk of soft tissue compromise, neurovascular complication, and compartment syndrome. This novel technique for reduction permitted percutaneous internal fixation due to the satisfactory alignment obtained from the closed reduction maneuver. Early closed reduction obviates the need for acute open reduction and limits soft tissue morbidity. This permits orthopaedic surgeons to non-urgently manage Lisfranc fracture-dislocations with definitive surgical fixation that is amenable to either percutaneous techniques or open reduction and internal fixation.
To study women at risk of PIH (Primi & Multi) by colour doppler velocimetry of uterine arteries
Authors: Inani Anita , Vashisth Pratibha , Rathore Priyanka 
Published: December 2023

The aim of the study is to study women at risk of PIH (Primi & Multi) by Colour Doppler velocimetry of uterine arteries. Pregnant women attending the antenatal clinics, screened for possible participation in the present study after explaining the nature of the study. A patient was diagnosed to have PIH if there was a rise in systolic pressure of at least 30 mmHg or a diastolic of at least 15 mmHg over the previously known blood pressure or an absolute rise in the blood pressure of at least 140/90 mmHg was taken to diagnose women as a case of PIH. Out of the 100 cases, maximum 35 cases (35%) were low risk primigravidae, followed by cases with history of PIH (15%), obesity (14%), Anemia (10%),Essential hypertension (7%), IUGR (7%),Which constitute 53%. Rest of the cases was family history of hypertension (6%), oligohydromnios (5%) and Twin (1%).Maximum cases i.e. 40% were illiterate, 28% cases were educated up to primary school and only 20% were educated up to middle school and above. Total 60% cases were literate. 77.2% babies were alive, Abortion were 5.3% and 16.76% cases were with poor perinatal outcome. Study shows that 22% cases showed abnormal waveform in colour Doppler, out of which 90.90% developed PIH, while 78% cases were with normal waveform out of which only 10.25% developed PIH later. For prediction of IUGR out of 22% of abnormal waveform 86.36 developed IUGR and out of 78% of normal waveform 20.51% developed IUGR. We conclude that a women with high risk factor (nulliparity and others) having abnormal uterine artery waveforms between 16-28 weeks of gestation (presence of diastolic notch with/without high resistance) are at higher risk of development of PIH (90.90%) and IUGR (95%). An important aspect is the high negative predictive value for PIH (89.74%) and IUGR (78.66%) which helps to detect those patient who will not develop PIH and IUGR early positive prediction enables, one to take preventive measures early thus improving both maternal and perinatal prognosis.
Antifungal Activity of Selaginella plana (Desv. ex Poir.) Hieron Extract Against Candida albicans In Vitro
Authors: Juen Carla Warella  , Khairunnida Rahma  , Agung Dwi Wahyu Widodo  , Rebekah Juniati Setiabudi  
Published: December 2023

Highlights:
1. A study on the medical benefits of Selaginella plana has significant academic value due to its extensive traditional usage among the Moluccan people as a medicinal remedy, especially for its antifungal properties.2. The findings of this study will allow further screening to determine the mechanism of action of bioactive compounds in inhibiting the growth of Candida albicans

Abstract
Candidiasis is an opportunistic infection caused by Candida albicans. This infection commonly affects the skin, oral mucosa, vagina, and gastrointestinal tract. Excessive use of azole antifungals in the treatment of Candida albicans infections can lead to the development of resistance. Therefore, it is necessary to explore alternative treatments using medicinal plants such as Selaginella plana, commonly referred to as “rutu-rutu” in a local language spoken across Maluku, Indonesia. Selaginella plana contains active compounds belonging to various chemical classes, including terpenoids, steroids, flavonoids, and saponins. This study aimed to determine the ability of Selaginella plana extract as an antifungal agent against Candida albicans by evaluating its inhibitory and antifungal effects. This study used an actual experimental design and broth dilution method. The research methodology involved the extraction of Selaginella plana using a solvent of 96% ethanol. The extract was then prepared in various concentrations, i.e., 100%, 50%, 25%, 12.5%, 6.25%, and 3.125%. Additionally, ketoconazole and distilled water were included in the experiment for the positive and negative controls, respectively. The results of this study demonstrated that Selaginella plana extract inhibited the growth of Candida albicans when administered starting at a concentration of 12.5%. However, the antifungal potential of Selaginella plana extract that induced cell death was only observed at a concentration of 100%. The fungicidal activity was exclusively identified in the undiluted, pure extract. The inhibitory and cytotoxic effects of Selaginella plana on Candida albicans cells were attributed to the presence of bioactive compounds in Selaginella plana, including flavonoids, tannins, terpenoids, and saponins. These bioactive compounds had the ability to inhibit cell growth by altering membrane permeability, causing mitochondrial dysfunction, and disrupting ergosterol biosynthesis. It can be concluded that Selaginella plana extract can act as a fungistatic agent against the proliferation of Candida albicans.
Toxicity Test on the Combination of Caesalpinia sappan and Zingiber officinale in Rattus norvegicus Induced by Complete Freund's Adjuvant
Authors: Salma Nadiah Armadanti , Tukiran  , Suyatno Sutoyo  , Fauzia Indah Sabila  
Published: December 2023

Highlights:1. This study determined the toxic effects of combining Caesalpinia sappan and Zingiber officinale extracts, aspeople need to be aware of the potential side effects of these common herbal remedies for the treatment ofrheumatoid arthritis.2. The combination of Caesalpinia sappan and Zingiber officinale extracts is efficacious and non-toxic as an antiarthritis treatment, hence, the ingredients can be upgraded to standardized herbal medicines andphytopharmaceuticals.

Abstract
Sappanwood (Caesalpinia sappan) and red ginger (Zingiber officinale) are plant species that have been studied for theirefficacy in treating inflammation related to rheumatoid arthritis. This study aimed to examine the effects of combiningsappanwood and red ginger in order to determine the potential toxicity of the herbal extracts in medicine. The toxicitytesting was carried out in vivo using 32 Wistar strain male white rats (Rattus norvegicus) grouped into eight groups of four.The rats were injected with complete Freund's adjuvant to induce a chronic inflammatory effect. The eight groups consistedof the negative control group, the positive control group, the normal group, and five treatment groups. This study wasconducted by observing the animals for toxic symptoms and death to determine the safety of the extracts and drugs. Theobservation results were analyzed using a one-way analysis of variance (p<0.05). The analysis results showed that weightgain and relative organ weight among the groups had no significant differences (p>0.05). Microscopic examination of theorgan preparations observed under a light microscope revealed no significant changes or adverse effects in rats treated withthe extracts or drugs. In conclusion, a combination of sappanwood and red ginger ethanol extracts administered orally hasno toxic effect in rats injected with complete Freund's adjuvant.
Clinical applications and efficacy of mirror neuron function
Authors: Musioł Aleksandra , Paluch Hanna , Samoń-Drzewicka Anna , Marcinkowska-Gapińska Anna 
Published: December 2023

Mirror therapy aims to restore the function of a disabled body part by using the function of mirror neurons in the brain and mimicking the physiological activity of a healthy body part. The existence of mirror neurons was first discovered in the monkey brain, then they were proven to occur in the human brain. The working pattern is always the same. If one limb moves, the correct part of the brain is activated and the mirror neurons responsible for stimulating the other limbs are activated. This is how the "mirror" in the brain works. The therapy uses a box with a mirror on one side and hides the impaired limb in it.. When a healthy limb moves, it is reflected in the mirror. The brain receives it as a movement of an inefficient limb, even though it is only an illusion. It drives the recruitment of neural joints and provides the reconstruction of neural pathways. The activity of mirror neurons is used in rehabilitation, in mirror therapy (MT), observational action therapy (AOT) and their variants, such as therapies based on Virtual Reality (VR). A significant effect of this treatment was observed in phantom limb pain (PLP) and post-stroke syndromes, such as motor aphasia, hemiparesis of the lower or upper limb. There are reports on the use of MT in some mental diseases or in autistic people in learning emotions. This review outlines the current possibilities and hopes for therapies based on mirror neuron functions based on selected cases.
Blood Loss in Primary Unilateral Total Knee Arthroplasty with Limited Tourniquet Application
Authors: Diri Doried , Alasaad Hakam , Abou Ali Mhana Sedra , Muhammed Hussain , Ibrahim Jaber 
Published: December 2023

Background:
Tourniquet application in total knee arthroplasty (TKA) has many benefits and may have a role in the incidence of perioperative complications. Our aims were to examine the safety of applying a tourniquet for a limited amount of time during primary unilateral TKA (specifically, during cementation and final component fixation only) and to compare perioperative complications between the limited-application group and the full-application group.

Methods:
We conducted a randomized controlled study of 62 patients undergoing primary unilateral TKA. Patients were randomly allocated to either the limited or full tourniquet application. The follow-up period was 6 months. We evaluated intraoperative, postoperative, total, and hidden blood loss as the primary outcome measures and clearance of the surgical field, operative duration, and perioperative complications as the secondary outcome measures.

Results:
We found a significant difference in surgical field clearance between the groups. There was no significant difference in total, hidden, or postoperative blood loss between the groups. Mean intraoperative blood loss was significantly lower in the full-application group than in the limited-application group (171.742 ± 19.710 versus 226.258 ± 50.290 mL; p = 0.001). Perioperative complications, including allogeneic blood transfusion rates, did not significantly differ between the groups.

Conclusions:
Limited tourniquet application is safe to use in primary unilateral TKA and does not increase the incidence of perioperative complications or total blood loss when compared with a standard, full-time tourniquet application.

Level of Evidence:
Therapeutic Level I. See Instructions for Authors for a complete description of levels of evidence.
A Deep Regression Method for Gas Well Liquid Loading Prediction
Authors: Chen Yan , Miao Bo , Wang Yang , Huang Yunan , Jiang YuQiang , Shi Xiangchao 
Published: December 2023

Summary
Liquid loading occurs when gas production falls below the critical liquid-carrying flow rate of the gas well, resulting in the inability to remove the condensate or water in the gas well. Liquid loading can lead to a sharp reduction in production, which affects the gas well ultimate recovery. Accurate prediction of the timing of liquid loading is important for implementing mitigations that reduce liquid accumulation in the production tubing and prevent gas production impairment, as well as for the stability of production. Existing liquid-loading forecasting methods have a time offset in the determination of liquid loading, and there is great variation in the results for different gas wells. Currently, supervisory control and data acquisition (SCADA) systems are widely used for gas well production data acquisition, but the data are not effectively utilized. Deep machine learning techniques are applied to the field data from gas wells and have achieved significant effectiveness. In this study, a bidirectional long short-term memory network (Bi-LSTM) was used to conduct feature extraction on the production data, and the extracted feature was spliced together with the geological and engineering parameter feature. These features were combined with self-attention mechanisms to predict the time of the next liquid loading. Because the modeling results fit the actual liquid loading in production scenarios better, our method also customizes the loss functions. Experimental verification was conducted using actual production data from 13 gas wells. The recall was 1 and F1 was 0.87 for the experimental data in the model, and the customized loss function led to a 6.5% improvement in F1. The experimental results verify that our method can accurately forecast liquid-loading onset in gas wells in a timely manner, which can help reduce costs and increase efficiency in shale gas production.
High performance of Amazonian Trichoderma strains in the control of southern blight caused by Sclerotium rolfsii in tomatoes
Authors: Cunha Arielton Nascimento , Netto Rosalee Albuquerque Coelho , Willerding André Luis , Assis Luiz Alberto , Sousa Thiago Fernandes , Caniato Fernanda Fátima , Silva Gilvan Ferreira da , Hanada Rogério Eiji 
Published: December 2023

Abstract
The Trichoderma genus is considered one of the most promising in the control of phytopathogens. The mechanisms of antagonism that are common among Trichoderma species are mycoparasitism and competition for space and nutrients. Some species also show antibiosis through the production of secondary metabolites with antimicrobial activity, lytic enzymes and volatile compounds. Trichoderma species-mediated biocontrol can be exerted by indirect mechanisms such as induction of resistance. In the search for efficient isolates of Trichoderma spp. for the biological control of southern blight in tomato plants (Solanum lycopersicum), 33 isolates were evaluated for the Sclerotium rolfsii mycelial growth inhibition (MGI) via a dual culture method and for incidence of disease reduction in tomatoes (Yoshimatsu L-3 cultivar) under greenhouse conditions. The experiment was with five isolates that showed the best results in the biocontrol of southern blight, and these isolates were identified via phylogenetic analysis based on partial sequencing of the tef1-α gene. Three isolates completely inhibited the disease symptoms, namely, INPA 2473 (T. endophyticum), INPA 2951 (T. asperelloides) and INPA 2957 (T. rugulosum); while the T. asperellum isolates INPA 2959 and INPA 2961 reduced the disease incidence to 6.6 and 13.33%. Although all the isolates showed a mycelial growth inhibition rate of over 50%, curiously, the isolates with the best performance in the dual culture assays were not the best at controlling the disease under greenhouse conditions. In addition, this work reports new record of Trichoderma rugulosum in Brazil.
Effect of cover crops on the suppressiveness of root rot and on the agronomic characteristics of cassava
Authors: Sousa Maria Cristiane Pereira , Diamantino Maria Selma Alves Silva , Hohenfeld Camila Santiago , Vidal Cristiana Bomfim Moreira , de Oliveira Saulo Alves Santos 
Published: December 2023

Abstract

Cassava (Manihot esculenta Crantz) is a major staple food in many developing countries, including Brazil. However, it faces significant challenges from diseases like dry root rot (DRR) and black root rot (BRR) caused by soil-borne fungi. This study explores the use of cover crops to suppress these diseases and improve cassava's agronomic traits. Over four cultivation cycles, various cover crops were alternated with cassava varieties 'BRS Kiriris' (resistant) and 'BRS Formosa' (susceptible) in soil infested with DRR and BRR pathogens. In the 2nd cycle, only germination showed significant differences, but by the 4th cycle, various agronomic parameters, including fresh weight (FW.AP), dry weight (DW.AP) of the aerial part, fresh weight (FW.Root), dry weight (DW.Root) of the roots, and plant vigor, exhibited significant improvements. Cowpeas were identified as the most effective cover crop in disease reduction (ID%) and promoting healthier and taller cassava plants. Jack beans and peanuts also had positive effects on vigor, FW.AP, DW.AP, FW.root, and DW.root. In contrast, cover crops like maize, black oats, Crotalaria ochroleuca, cassava, and fallow soil had minimal impacts. Throughout the cycles, these selected cover crops consistently contributed to disease reduction and improved cassava's agronomic characteristics. This research highlights their potential in holistic disease management strategies.
Differences in Sleep Quality and Timing Influence Long Term Forgetting of Verbal Episodic Memory, and Face Processing
Authors: Avery Mark , Lever Colin , Anderson Kirstie 
Published: December 2023

Abstract
We examined cognition-specific effects of sleep quality and timing in 145 cognitively-normal subjects (M=55.3 years), using self-report (Pittsburgh Sleep Quality Index, PSQI) and actigraphy, testing whether NREM-rich sleep supports long-term consolidation of declarative memory, while REM-rich sleep supports facial processing. Good sleep is thought to improve declarative memory consolidation, but its potential role in longer-timescale forgetting (e.g., 2 weeks after the learning event) is largely unexplored. We modified a standard test of verbal episodic memory (VEM) to test 2-week retention relative to 30-minute delay performance. Subjects also completed other cognitive tasks and psychological questionnaires. We analysed predictors of VEM Long-Term Forgetting and Facial processing. Good quality sleep (PSQI), good psychological health (questionnaires) and being an early sleeper (actigraphy), i.e. likely obtaining more NREM-rich sleep, predicted better/lower VEM Long-Term Forgetting. Conversely, being a late sleeper (actigraphy), i.e. likely obtaining more REM-rich sleep, predicted better Facial processing. To our knowledge, this is the first indication that sleep quality influences long-timescale (2-week) consolidation of a single learning episode, and that later-sleeping community-living subjects have superior facial processing. These novel findings are consistent with research showing associations between good sleep quality and higher NREM sleep, and between early-stage NREM sleep and long-term memory consolidation. Since the benefits of good sleep for long-term forgetting applied to older as well as younger participants, these findings also re-emphasise the importance of sleep health in older adults.
STX11 p.R129P variant correlate with an in vitro impairment in NK and CD8+ T-cell-mediated cytotoxicity
Authors: Erra Lorenzo , Colado Ana , Brunello Francisco , Prieto Emma , Goris Verónica , Villa Mariana , Oleastro Matías , Martí Marcelo , Pozner Roberto , Borge Mercedes , Danielian Silvia , Almejun María Belén 
Published: December 2023

Abstract
STX11 encodes a t-SNARE protein essential for the final fusion of lytic granules with the plasma membrane of NK and CD8+ T-cells. Biallelic mutations in STX11 have been associated with familial hemophagocytic lymphohistiocytosis (FHL) type 4. Here, we analyzed the functional relevance of an heterozygous STX11 variant (p.R129P) identified in a pediatric patient diagnosed with Evans syndrome. Structural analysis suggested that the proline replacement at position 129 could impact key protein-protein interaction with Munc18-2. We found that patient’ cells carrying p.R129P mutation showed a decrease in NK-cell degranulation and cytotoxicity, and in CD8+ T-cell degranulation as compared to healthy donors. In vitro treatment of patient derived cells with IL-2, restored both functions to levels comparable as those observed in healthy donors. We also observed reduced STX11 protein expression in patient PBMC’s and impaired TLR4 re-localization in the patient's monocytes. Our findings provide evidence for the pathogenic role of the p.R129P-STX11 variant, and suggest that aberrant NK-cell and T-cell function may contribute to the development of autoimmune disorders.