bluuebunny/crossref_metadata_2025_split huggingface dataset:
A utility of holistic health in shrimad bhagavad gita and patanjali Yog Sutra: A review
Authors: Negi Kavita , Tanushree  , Chaurasia Nandani 
Published: November 2023

Stress, poor eating, smoking, drinking, drug use, and malnutrition contribute to an unhealthy lifestyle. A harmful lifestyle results in medical issues such as metabolic disorders, joint and bone disorders, cardiovascular diseases, hypertension, obesity, and aggression. WHO states, "Health is a complete physical, mental, and social well-being and not merely the absence of disease or infirmity." Recently, a fourth dimension of spiritual health has also been suggested but has failed to define it in a way that distinguishes it from religion. The clarifies coping strategies for a variety of life circumstances. The dialogue between Lord Krishna and Arjuna demonstrates constructive coping mechanisms. The purpose of all these spiritual paths is known as yogas, which include , which focuses on knowledge, , which emphasizes effort; and which emphasizes love and devotion. The recommends specific foods (Sattvic, Rajasic, and Tamasic) to help us maintain our compassion after consuming them. The Gita claims that Lord Krishna informed us of the consequences of eating particular foods. Simultaneously, practicing the develops a physically fit personality, emotionally stable, intellectually brilliant, and spiritually awakened nature. Patanjali mentions four propounds the or eight parts or limbs. This review highlighted the concepts of holistic health limited to , and the mentioned in the and in .
Prevalence of mental illness among women in an urban slum area of Jaipur: A cross- sectional study
Authors: Sinha Sweta , Sharma Shubham Mohan , Shrivastava Prabha , Bankwar Vishal 
Published: November 2023

Gender has been described as a critical determinant of mental health and mental illness. Depression is not only the most common women's mental health problem, but may be more persistent in women than men.To assess the burden of depression, anxiety and stress among women residing in urban slums of Jaipur and also to assess the factors affecting them. A community based cross-sectional study was conducted in an urban field practice area among women aged 18-59 years with calculated sample size of 503. Depression Anxiety Stress Scale (DASS)-21 questionnaire was used to capture the primary outcomes—depression, anxiety, and stress. Data was analyzed using SPSS and MS Excel. The statistical significance was evaluated at 95% confidence level. The difference in proportions was compared using Chi-square test and p-value &#60;0.05 was considered significant. In our study, the overall, the prevalence of anxiety, stress and depression was 38.22%, 9.11%, and 18.61%, respectively which ranged from mild to extremely severe. There were meaningful correlations between probable factors like physical inactivity, poor sleep and generalized pain and DASS scores obtained by the participants. The study showed that the prevalence of anxiety was higher compared to other DASS symptoms. The DASS symptoms were poorly associated to demographic characteristics of the study participants although amongst the separated and widowed females there was significant statistical association.
Efficacy of pranic healing for inch-loss
Authors: Renjhen Prachi , Jha Ravi Prakash , Thirani Saurabh 
Published: November 2023

Pranic Healing is an ancient science and art of healing that uses Prana or Life force to heal the whole physical body. It is a no-drug, no-touch energy healing modality taught by Master Choa Kok Sui since 1987. The study aimed to assess if a single session of Pranic Healing can lead to inch loss.An interventional study was conducted with 49 volunteers who desired waist circumference reduction. Baseline waist circumference measurements were collected from all participants. This was followed by a single 60-minute session of Distant Pranic Healing administered by a Certified Practitioner.Waist circumference measurements were recorded immediately after the healing session. The data analysis showed that post-intervention there was a statistically significant reduction in the measured waist circumference for the study group for over 90% of the study participants. These results prove that Pranic Healing can aid as a modality for inch loss. It is remarkable to note that a reduction of waist circumference was achieved in a 60-minute Pranic Healing session without using any drugs, gadgets, or physical contact.
Violência, política de gênero e fake news
Authors: Bertolin Patrícia Tuma Martins , Alves Tamires Torres 
Published: November 2023

O presente artigo tem por objetivo abordar a violência política de gênero e as fake news. A priori, se fará uma análise do termo violência, nas suas dimensões direta, estrutural e cultural, para verificar a incidência no âmbito político, em relação as mulheres. Após, estudaremos a Lei nº 14.192, de 4 de agosto de 2021, que estabelece normas para prevenir, reprimir e combater a violência política contra a mulher. Por fim, passaremos a estudar a ocorrência da violência política contra a mulher nos meios digitais, com enfoque na desinformação e fake news, bem como os prejuízos ao pleito eleitoral, em consequência, à Democracia.
Isotopic evidence for nickel limitation of biological productivity in the ocean
Authors: Wang Tzu-Hao , Zhang Qiong , Hsieh Tu-Te , Henderson Gideon , Rickaby Rosalind 
Published: November 2023

Abstract
Nickel (Ni) is an essential element for many important enzyme systems1,2. Two puzzling aspects of Ni biogeochemical cycling in the modern ocean have emerged. First, unlike a number of bio-essential elements, Ni is never fully depleted in the surface ocean3-13. Second, a heavy Ni isotopic composition in the surface ocean, indicative of removal of light isotopes likely by productivity, is not observed globally6-13. Active debate persists regarding the isotopic fractionation of Ni associated with biological uptake and the bioavailability of Ni in the ocean7,9,11-13. Here we show that, in contrast to biological isotopic fractionation for most other elements, three cosmopolitan phytoplankton species preferentially take up isotopically heavy Ni from the culture media, with species-dependent magnitudes of fractionation, under varying Ni availability. This fractionation towards heavy Ni isotopes can be explained, in our experiments, by the characteristic strong Ni-binding of cellular metal acquisition systems, relative to weaker binding by ligands in the culture media, with a secondary influence of cellular relocation and/or efflux. In the open ocean, an inferred stronger binding of Ni to ligands present in seawater, relative to that of the phytoplankton, yields the inverse fractionation (towards light isotopes in the biomass) and limits the bioavailability of metals in the surface ocean. Reconciling seawater Ni concentration and isotope data, results from incubation experiments, and marine gene biogeography, we demonstrate that Ni is limited for marine phytoplankton in the mid-latitude surface ocean with low Ni concentration and heavy Ni isotope composition, with implications for the significance of Ni bioavailability on both ocean productivity and carbon cycling.
Developing innovative Filtration Membranes based on SiO2/TiO2/Cdot(N) for wastewater treatment.
Authors: Name Luccas L , Tiba Daniel Y , Canevari thiago C 
Published: November 2023

Abstract
This work describes a new, cost-effective modified filtration membrane for wastewater treatment containing different substances. The filtration membrane comprises a nylon substrate modified by SiO2/TiO2/Cdot(N) nanostructures in situ. SiO2/TiO2/Cdot(N) nanostructures have been prepared using nitrogen-doped carbon quantum dots (Cdot(N)), electrochemically synthesized by oleylamine, which was also applied as reaction catalysts between titanium isopropoxide and silica source. FTIR, Raman spectroscopy, SEM, EDS, and HR-TEM characterized SiO2/TiO2/Cdot(N) nanostructures. The membrane operated as a rapid filtration tool and presented good sorbent capacity, 10 mg of methylene blue, 4.2 mg of methyl orange, and 17.3 mg of bisphenol A per gram of sorbent obtained by standard addition method. The waste removal capacities were calculated using UV spectroscopy at 275, 464, and 664 nm wavelengths. The filtration membrane composed of a nylon membrane substrate modified by SiO2/TiO2/Cdot(N) nanostructures presents an excellent performance in retaining this substance in a real water sample.
The prognostic value of tumor-stroma ratio and a newly developed computer-aided quantitative analysis of routine H&amp;E slides in high-grade serous ovarian cancer
Authors: wagensveld lilian van , Walker Cedric , Hahn Kerstin , Sanders Joyce , Kruitwagen Roy , Aa Maaike van der , Sonke Gabe , Rottenberg Sven , de Vijver Koen Van , Janowczyk Andrew , Horlings Hugo 
Published: November 2023

Abstract
Introduction: Tumor-stroma ratio (TSR) is prognostic in multiple cancers, while its role in high-grade serous ovarian cancer (HGSOC) remains unclear. Despite the prognostic insight gained from genetic profiles and tumor-infiltrating lymphocytes (TILs), the prognostic use of histology slides remains limited, while it enables the identification of tumor characteristics via computational pathology reducing scoring time and costs. To address this, this study aimed to assess TSR's prognostic role in HGSOC and its association with TILs. We additionally developed an algorithm, Ovarian-TSR (OTSR), using deep learning for TSR scoring, comparing it to manual scoring. Methods: 340 patients with advanced-stage who underwent primary debulking surgery (PDS) or neo-adjuvant chemotherapy (NACT) with interval debulking (IDS). TSR was assessed in both the most invasive (MI) and whole tumor (WT) regions through manual scoring by pathologists and quantification using OTSR. Patients were categorized as stroma-rich (≥ 50% stroma) or stroma-poor (< 50%). TILs were evaluated via immunohistochemical staining. Results: In PDS, stroma-rich tumors were significantly associated with a more frequent papillary growth pattern (60% vs 34%), while In NACT stroma-rich tumors had a lower Tumor Regression Grading (TRG 4&5, 21% vs 57%) and increased pleural metastasis (25% vs 16%). Stroma-rich patients had significantly shorter overall and progression-free survival compared to stroma-poor (31 versus 45 months; P < 0.0001, and 15 versus 17 months; P = 0.0008, respectively). Combining stromal percentage and TILs led to three distinct survival groups with good (stroma-poor, high TIL), medium (stroma-rich, high TIL, or; stroma-poor, Low TIL), and poor(stroma-rich, low TIL) survival. These survival groups remained significant in CD8 and CD103 in multivariable analysis (Hazard ratio (HR) = 1.42, 95% Confidence-interval (CI) = 1.02–1.99; HR = 1.49, 95% CI = 1.01–2.18, and HR = 1.48, 95% CI = 1.05–2.08; HR = 2.24, 95% CI = 1.55–3.23, respectively). OTSR was able to recapitulate these results and demonstrated high concordance with expert pathologists (correlation = 0.83). Conclusions: TSR is an independent prognostic factor for survival assessment in HGSOC. Stroma-rich tumors have a worse prognosis and, in the case of NACT, a higher likelihood of pleural metastasis. OTSR provides a cost and time-efficient way of determining TSR with high reproducibility and reduced inter-observer variability.
Management of Knee OsteoArthritis(KOA) is improving:A scoping review and quality appraisal of Clinical Practice Guidelines for KOA using the AGREE II and RIGHT
Authors: Liu Luping , Wang Xiyou , An Yi , Zhang Lingyun , Gao Yixuan , Yu Changhe 
Published: November 2023

Abstract
Background : Clinical practice guidelines (CPGs) are essential in healthcare, but their quality varies. This study aims to analyze 18 high-quality CPGs for knee osteoarthritis (KOA), identify areas for improvement, and establish common recommendations from contemporary CPGs for effective KOA management.Methods: We systematically searched guideline websites and databases until June 30, 2023, for KOA-related guidelines. Two independent reviewers assessed these using AGREE II and RIGHT checklists. The intra-class correlation coefficient (ICC) evaluated reviewer agreement, and recommendations and evidence levels were summarized.Results: We analyzed 18 Clinical Practice Guidelines (CPGs) from 1,411 records. Most were from China and the USA, published from 2016 to 2022, with 44.44% updates. Methodological quality was reliable, with 14 CPGs "recommended," but three had low "editorial independence" scores. Reporting quality ranged from 41.43–95.71%, with 66.66% scoring ≥ 80%. Recommendations included conservative measures, Tai Chi, Yoga, cane use, and various complementary and alternative medicines. Topical NSAIDs, oral NSAIDs, and intra-articular glucocorticoids were favored. Foreign guidelines stressed shared decision-making and patient preferences in KOA management.Conclusions: Over half of KOA CPGs are of good quality. However, there's substantial methodological variation and reporting quality gaps. Future efforts should enhance both. Our research supports a core set of interventions, including education, exercise, weight management, and personalized NSAID use, for evidence-based KOA practice and guideline development
Tumor necrosis factor- α Inhibition analysis by chemotherapy agent through QM/MM studies
Authors: S Mohammed zaidh , Navabshan IRFAN , M Salman 
Published: November 2023

Abstract
TNF (Tumor Necrosis Factor) is a multifunctional cytokine with a strong pro-inflammatory action and it is a proven therapeutic target receptor for a variety of autoimmune and inflammation-related illnesses. The current investigation is looking for a new chemotherapy small lead molecule that can directly bind to TNF receptors and modify the conformation. The TNF-α fold was docked with the 56 AI-designed molecules by a three-step algorithm in the Schrodinger Maestro interface. The interaction analysis results revealed that the best-hit molecule with a binding capacity score of -6.987 Kcal/mol and the MMGBSA value was found to be -52.42 Kcal/mol with the TNF receptor. Interaction map illustrates that 29 active amino acid of TNF receptor networked through 3 hydrogen bond, hydrophobic, 2 Salt bridges and negative charges type interactions with ring system such as piperazine and azetidine od the best hit molecule. Further, the environment solvent stability was confirmed using MD simulation in Desmund interface and analyzed the trajectory at 100 ns scale level, and it concludes that the formed bonds are 40–99% strong enough to modify the secondary structure of the TNF-α. Which leads target specific inhibition and safe chemotherapy agent for Tumor necrosis factor (TNF-α)
Caregivers’ Treatment-Seeking Time for Diarrhea in Under-Five Children in Uganda: A Multilevel Proportional Hazards Analysis
Authors: Tumusiime Sula , Asimwe John Bosco , Atuhaire Leonard , Wasswa Ronald , Nsimbe Dick , Brian Kayera 
Published: November 2023

Abstract
Background
Diarrhea is considered to be one of the major public health concern in developing countries. It is attributed to one of the highest mortality rates among children both globally and in Sub-Sahara Africa with 2 in 10 children in Uganda under the age of 5 dying. The objective of this study was to investigate the factors associated with time to seeking treatment among children under the age of five years suffering from diarrhea in Uganda.
Method
DOVE dataset of 746 caretakers in a prospective cohort study using multi stage sampling design was used in the assessment. The analysis was done using a time-to-event approach using life tables and multilevel proportional hazards model.
Results
The median time to seeking treatment by the time of the study (N = 746) was 2 days (range, 1–30 days) from the onset of diarrhea. The estimated frailty variance is 0.128, indicating heterogeneity across regions. Significant factors found to influence time to diarrhea treatment seeking include male children (HR = 0.821; 95% CI = 0.707–0.954, p = 0.010), those from richest wealth quintile (HR = 1.372; 95% CI = 1.051–1.791, p = 0.020), those living 5–10 KM from health facility (HR = 0.613; 95% CI = 0.411–0.912, p = 0.016), and those living more than 15 KM from health facility (HR = 0.695; 95% CI = 0.553–0.875, p = 0.002).
Conclusions
The findings are informative to policy on the behavior of seeking treatment. The results are also important in formulation of program strategies and interventions by different stakeholders that are geared towards reducing child morbidity and mortality due to diarrhea in relation to seeking treatment. The study also recommends other researchers to consider mixed methods analysis involving both qualitative and quantitative approach may provide a better understanding about the treatment seeking behaviors.
Inpatient outcome of upper cervical fractures in the elderly: a retrospective analysis of 268 cases.
Authors: Hoeh Nicolas Heinz von der , Keuchel Jonathan , Pieroh Phillip , Spiegl Ulrich Josef Albert , Osterhoff Georg , Heyde Christoph-Eckhard 
Published: November 2023

Abstract
Background
The incidence of upper cervical fractures in elderly individuals is increasing, necessitating enhanced treatment approaches.
Method
A retrospective study of 268 elderly patients with upper cervical fractures was conducted to assess inpatient outcomes aged 75 and older with atlas and/or axis fractures. Patient risk was evaluated using the ASA score and Charlson comorbidity index (CCI). In-hospital mortality and functional outcomes were assessed, with fracture treatment strategies following AO principles.
Results
Patients with C1, C2 or combined fractures did not differ in age, CCI, Barthel score or length of hospital stay (p > 0.05). C2 fractures were predominant, and the majority of patients suffered at least from a severe general disease (ASA ≥ 3). Comparing operatively and conservatively treated patients, regardless of fracture localization, revealed no significant differences in mortality, both overall and time-related. Surgical patients experienced a higher frequency of general complications, notably dyspnea. The overall mortality rate was 14.9%, with 15.7% in the nonoperative group and 14.4% in the surgical group (p = 0.8628). The overall rate of general complications was 51.4% (n = 51) in the nonoperative group and 71.9% (n = 110) in the operatively treated group.
Conclusion
The in-hospital mortality and morbidity of elderly patients with upper cervical fractures are high but do not significantly differ between operatively and nonoperatively treated patients. The complexity of the geriatric patient population highlights the need for peri- and postinpatient geriatric complex treatment, emphasizing the importance of establishing geriatric-specialized care structures.
Ontogenetic shifts in sex ratios support multiple adaptive explanations for temperature-dependent sex determination
Authors: Terebiznik Mariel , Farrell Maxwell , Rollinson Njal 
Published: November 2023

Abstract
Temperature-dependent sex determination (TSD) is found in all reptile groups, but its adaptive significance is a mystery. This is because most TSD reptiles feature extreme longevity, so assessing lifetime fitness is incredibly difficult. Here we combine classical sex ratio theory with a dataset of stage-specific sex ratios from a diversity of wild reptile populations to infer patterns of sex-specific mortality (fitness) across ontogeny. We disentangle whether there is a single or multiple adaptive explanations for TSD, provide insight into what those explanations are, and align the adaptive explanations with major reptile clades. We find that TSD evolved in turtles and crocodilians so that males develop in high-quality patches, supporting an extension of the Trivers-Willard hypothesis where the fitness of males under sexual selection is more sensitive to body condition than female fitness. We further find that stage-specific patterns of mortality are different in squamates, where TSD may have evolved to match females with high-quality patches that facilitate early maturation and high fecundity. We suggest if TSD evolved in long-lived reptiles because incubation temperature is a pervasive agent that influences stress, then it may be embryonic stress in general, not just thermal stress, that is the fundamental driver of TSD evolution.
Quality Improvement Project to Transition Psychosocial Oncology Clinical Care to a Telehealth Workflow during the COVID-19 Pandemic: a Quasi-Experimental Study
Authors: Sethi Rickinder , Lyver Brendan , Gorla Jaswanth , Forbes Robin , Sheehan Kathleen A , Schulz-Quach Christian 
Published: November 2023

Abstract
Introduction.
The COVID-19 pandemic created an urgent need for an innovative method of care delivery for psychosocial oncology. The psychosocial oncology services at the University Health Network in Toronto, Canada transitioned expeditiously to digital technologies that were readily available and accessible for patients and clinicians, facilitating care provision while reducing the transmission of COVID-19. This study aims to provide a validated framework for transitioning to digital delivery methods of care.
Methods.
A quality improvement team was established and tasked with successfully transitioning services from primarily in-person to digital delivery methods of care quickly and seamlessly. This included analyzing the psychosocial oncology workflow, planning and implementing a digital transition, and collecting data and feedback on the impact of this digital workflow through the use of surveys.
Results.
The average response rate of the surveys was 69.1%. Feedback and data collection demonstrated that more than 90% of psychosocial oncology processes were completed with digital tools following the transition with limited impact on clinical delivery. The clinicians reported feeling confident and satisfied providing care using digital workflow tools.
Conclusion.
The psychosocial oncology quality improvement team at the University Health Network provides a validated framework for transitioning to new methods of delivering care. As technology continues to develop, guidance on transitioning clinics and departments to new digital tools will be crucial for healthcare institutions. The framework provided in this study can be utilized to ensure the successful implementation of new technologies.