bluuebunny/crossref_metadata_2025_split huggingface dataset:
The dual‐action mechanism of Arabidopsis cryptochromes
Authors: Qu Gao‐Ping , Jiang Bochen , Lin Chentao 
Published: October 2023

ABSTRACTPhotoreceptor cryptochromes (CRYs) mediate blue‐light regulation of plant growth and development. It has been reported that Arabidopsis CRY1and CRY2 function by physically interacting with at least 84 proteins, including transcription factors or co‐factors, chromatin regulators, splicing factors, messenger RNA methyltransferases, DNA repair proteins, E3 ubiquitin ligases, protein kinases and so on. Of these 84 proteins, 47 have been reported to exhibit altered binding affinity to CRYs in response to blue light, and 41 have been shown to exhibit condensation to CRY photobodies. The blue light‐regulated composition or condensation of CRY complexes results in changes of gene expression and developmental programs. In this mini‐review, we analyzed recent studies of the photoregulatory mechanisms of Arabidopsis CRY complexes and proposed the dual mechanisms of action, including the “Lock‐and‐Key” and the “Liquid‐Liquid Phase Separation (LLPS)” mechanisms. The dual CRY action mechanisms explain, at least partially, the structural diversity of CRY‐interacting proteins and the functional diversity of the CRY photoreceptors.
Clinicopathological characteristics of cutaneous complications following COVID‐19 vaccination: A case series
Authors: Diab Reem , Rakhshan Azadeh , Salarinejad Sareh , Pourani Mohammad Reza , Ansar Padideh , Abdollahimajd Fahimeh 
Published: October 2023

AbstractIntroductionSeveral vaccine‐related cutaneous adverse events occurred following the widespread use of vaccines to prevent coronavirus disease 2019 (COVID‐19). This case series reports 25 patients with de novo or accentuated dermatologic conditions after receiving the Sinopharm, Sputnik V, AstraZeneca, or BIV1‐CovIran vaccine in Iran.Methods and ResultsTwenty‐five eligible patients with a mean age of 46.80 years were investigated. The cutaneous adverse events included pityriasis rosea, zoster, viral exanthema, urticaria, bullous pemphigoid, pemphigus vulgaris, and acute generalized exanthematous pustulosis. The manifestations appeared 14.45 ± 6.98 and 20.79 ± 22.18 days following injection of the first and second doses of COVID‐19 vaccines, respectively. All patients experienced new cases of cutaneous disease other than two who developed flare‐ups of lichen planus and psoriasis.ConclusionSeveral cutaneous reactions, ranging from allergic events to skin diseases, have been reported following the injection of COVID‐19 vaccines. Focal injection‐site reactions are the most common cutaneous adverse events; however, de‐novo skin diseases and a flare‐up of preexisting cutaneous disorders have also been described. Although many cases of COVID‐19 vaccine‐related cutaneous diseases have been published, our zoster/lichen planus and AGEP cases after vaccination are interesting. A more detailed understanding of cutaneous adverse events following COVID‐19 vaccination will facilitate better diagnosis and management.
Human capital in Europe, 1830s–1930s: A general survey
Authors: Cappelli Gabriele , Ridolfi Leonardo , Vasta Michelangelo , Westberg Johannes 
Published: October 2023

AbstractHuman capital is now widely acknowledged as one of the key determinants of economic growth. Research on how human skills accumulate and evolve through time has grown rapidly in recent years. This paper surveys it with a specific focus on Europe in the period 1830s–1930s. Our contribution is threefold: First, we find that the lack of fine‐grain spatial and (at the same time) harmonized data is preventing research on some important aspects of rising education. Second, we provide a preliminary taxonomy of European school acts and reforms in the 19th and early‐20th century. Finally, we present the first version of a dataset under construction, which aims at providing spatial data covering gross enrollment rates and literacy across European regions from c. 1830 to 1930. Our preliminary results show that, in c. 1850, educational clusters appear to have often crossed national borders. By contrast, the effect of national institutions and regulations seems to have become an important determinant of schooling (and literacy) rates on the eve of the 20th century.
Assessment of utero‐cervical angle and cervical length as predictors for threatened preterm delivery in singleton pregnancies
Authors: Korkmaz Nazli , Kiyak Huseyin , Bolluk Gokhan , Bafali Olgu , Ince Osman , Gedikbasi Ali 
Published: October 2023

AbstractObjectivesThe aim of this study was to evaluate the relationship between the cervix and the threat of preterm labor in singleton pregnancies between gestational weeks less than 37 and greater than 37 weeks in correlation with utero‐cervical angle (UCA) and cervical length (CL) measurements.Materials and MethodsWe conducted a prospective cohort study with UCA and CL measurements in patients with threatened preterm labor (TPL). Primary outcome was differences in UCA and CL measurements in relationship to maternal characteristics and perinatal outcome between groups. Secondary outcome evaluated measurement results and influencing factors for delivery within 7 days, between 1 and 4 weeks and beyond 4 weeks.ResultsOverall 152 patients were divided into as study/preterm group (<37 weeks; n = 56) and the control/term group (≥37 weeks; n = 96). Mean gestational age at admission was similar in both groups (30.98 ± 2.83 vs. 30.36 ± 2.63 weeks, p = 0.149) with similar CL (33.9 ± 6.34 vs. 32.02 ± 8.88 mm, p = 0.132), but wider UCA in the preterm group (81.65 ± 16.81° vs. 99.21 ± 22.33°, p < 0.001). Multivariate logistic regression analysis for preterm delivery was significant for nulliparity and UCA measurement. The factor for delivering before 37 gestational weeks within 7 days was the gestational week at admission (p = 0.046). UCA and CL measurements were statistically significant for distinguishing patients for delivery within 7 days and beyond 4 weeks (p = 0.001 for CL and p = 0.0001 for UCA). NPV was found 92.5, 92.2, and 92.3 for UCA >105°, CL ≤30 mm, and Bishop score >3, respectively.ConclusionCombined measurement of TV UCA and CL represents stronger predictors for sPTB ultrasonographically, demonstrating the uterocervical sub‐segment maturation before the active onset of labor.
Does cardiovascular risk matter in IBD patients?
Authors: Tilg Herbert , Fumery Mathurin , Hedin Charlotte R. H. 
Published: October 2023

AbstractCardiovascular and thromboembolic risks are increasing in the population as a whole and therefore also in inflammatory bowel disease (IBD) patients. Obesity is a worldwide challenge also affecting the IBD population, and a causal association with Crohn's disease may exist. IBD itself, particularly when active, is also associated with a significant risk of thromboembolic and cardiovascular events such as myocardial infarction and stroke. Cardiovascular risk is also a significant consideration when using Janus kinase (JAK) inhibitors and sphingosine 1 phosphate (S1P) receptor modulators to treat IBD. JAK inhibitors – such as tofacitinib – are associated with several cardiovascular and venous thromboembolic risks, including hypertension and alterations in lipid profiles – specifically, increased LDL cholesterol and triglycerides – which may contribute to atherosclerosis and cardiovascular disease. S1P receptor modulators pose a slightly different set of cardiovascular risks. Initially, these drugs can cause transient bradycardia and atrioventricular (AV) block, leading to bradycardia. Moreover, they may induce QT interval prolongation, which increases the risk of life‐threatening arrhythmias such as torsades de pointes. Some patients may also experience hypertension as a side effect. In this context, IBD healthcare providers need to be alert to the assessment of cardiovascular risk – particularly as cardiovascular events appear to be confined to specific patient groups with pre‐existing risk factors. In addition, the potential for S1P modulator drug interactions requires a higher level of vigilance in patients with polypharmacy compared to biologics. Cardiovascular risk is not static, and updated assessment will need to become part of the routine in many IBD units.
Moral characteristics predicting COVID‐19 vaccination
Authors: Zher‐Wen  , Zhen Shanshan , Yu Rongjun 
Published: October 2023

AbstractObjectiveThe current study aims to assess, for the first time, whether vaccination is predicted by different behavioral and cognitive aspects of moral decision‐making.BackgroundStudies linking moral factors to vaccination have largely examined whether vaccination decisions can be explained by individual differences in the endorsement of various principles and norms central to deontology‐based arguments in vaccination ethics. However, these studies have overlooked whether individuals prioritize norms over other considerations when making decisions, such as maximizing consequences (utilitarianism).MethodIn a sample of 1492 participants, the current study assessed whether vaccination is explained by individual differences in three aspects of moral decision‐making (consequence sensitivity, norm sensitivity, and action tendency), while also considering ethics position (idealism, relativism) and moral identity.ResultsSupportive vaccination (vaccine uptake accompanied by a positive attitude toward vaccines) was associated with utilitarianism (increased consequence sensitivity) and increased tolerance to risks and harm toward others. Meanwhile, although those in the non‐vaccinated group was associated with higher harm sensitivities, they neither supported nor received the COVID vaccines (when vaccines prevent harm from infection).ConclusionPro‐vaccination messages may be made more effective by addressing perceptions of harms associated with vaccines and infections, respectively.
Diabetes self‐care behaviours among people diagnosed with serious mental illness: A cross‐sectional correlational study
Authors: Tzeng Wen‐Chii , Tai Yueh‐Ming , Feng Hsin‐Pei , Lin Chia‐Huei , Chang Yue‐Cune 
Published: October 2023

Accessible SummaryWhat is known on the subject?

People diagnosed with serious mental illness have a high risk of diabetes and are more likely to develop type 2 diabetes at ages below 60 years.

Effective diabetes self‐care behaviours among people diagnosed with serious mental illness can improve glycaemic control and reduce vascular complications.

Few studies have investigated diabetes self‐care behaviours and their associations with health literacy and self‐efficacy in people diagnosed with serious mental illness.

What the paper adds to existing knowledge?

Diabetes self‐care behaviours in people diagnosed with serious mental illness were suboptimal; the least frequently performed self‐care activities were self‐monitoring of blood glucose.

Factors associated with diabetes self‐care behaviours are gender, age, communicative and critical health literacy and self‐efficacy.

Self‐efficacy is the strongest predictor of self‐care behaviours among people diagnosed with comorbid serious mental illness and type 2 diabetes.

What are the implications of practice?

Mental health nurses should assess diabetes‐specific health literacy of people diagnosed with serious mental illness to ensure that they possess the knowledge and skills related to diabetes self‐care.

When treating young people and those with newly diagnosed type 2 diabetes, nurses should incorporate strategies to minimise their perceptions of diabetes‐related distress and increase their confidence in managing comorbid diabetes.

AbstractIntroductionPeople diagnosed with serious mental illness (SMI) experience greater challenges in managing their type 2 diabetes mellitus (T2DM) than do those diagnosed with T2DM alone.AimThis study investigated diabetes self‐care activities and the factors associated with these activities in people diagnosed with SMI in a hospital setting.MethodsA cross‐sectional correlational study was conducted among 126 people diagnosed with comorbid SMI and T2DM in Taipei, Taiwan, between October 2020 and April 2021. Data were collected using self‐report questionnaires and a chart review. Three‐step hierarchical multiple regression analysis was used to identify factors associated with diabetes self‐care behaviours.ResultsDiabetes self‐care behaviours in people diagnosed with SMI were suboptimal overall. Hierarchical multiple regression analyses revealed that age (β = 0.18, p = .037) and self‐efficacy (β = 0.27, p = .004) significantly associated with diabetes self‐care behaviours.DiscussionSelf‐efficacy is the strongest predictor of self‐care behaviours among people diagnosed with comorbid SMI and T2DM.Implications for PracticeMental health professionals should focus on enhancing confidence in managing comorbid diabetes in people diagnosed with comorbid SMI, especially young people and those with newly diagnosed T2DM.
The Acquisition of Strategies to Express Plurality in Hearing Second Language Learners of Sign Language of the Netherlands
Authors: Boers‐Visker Eveline 
Published: October 2023

AbstractThis study reports on strategies to indicate plural referents in hearing learners of Sign Language of the Netherlands. This is the first explorative study that focuses on L2 expressions of plurality in a sign language. Using data from two datasets, I examined when learners start to express plural and which strategies they apply, and I noted typical learner characteristics. The first study examined spontaneous conversations of three learners, during the first 18 months of their learning. The second study analyzed elicited data from 11 learners during their first year of learning. The data reveal that learners are able to express plural referents in early stages, using strategies that are familiar to them (quantifiers) as well as strategies that do not occur in their mother tongue (reduplication of the noun, use of spatial devices). The early emergence might be explained by the salient nature of the devices and the resemblance with gestural portrayals.
Frictions and the diffusion of automation
Authors: Charalampidis Nikolaos 
Published: October 2023

AbstractThis paper studies the implications of business cycle frictions for the diffusion of permanent changes in automation. Incorporating task‐based production in different versions of the New Keynesian model reveals considerable short‐run implications. Price‐distorting nominal rigidities amplify the labor displacement and attenuate the productivity and welfare gains of automation during the transition to the new equilibrium. They exacerbate the falls in the labor income share, the job finding probability, the value of long‐term contracts, and labor market tightness. The inflation response follows a J‐curve. Frictions in capital supply and wage rigidities amplify the labor displacement and attenuate the productivity gains too.
Phytoplanktonic species in the haloalkaline Lake Dziani Dzaha select their archaeal microbiome
Authors: Bruto Maxime , Oger Philippe M. , Got Patrice , Bernard Cécile , Melayah Delphine , Cloarec Lilian A. , Duval Charlotte , Escalas Arthur , Duperron Sébastien , Guigard Ludivine , Leboulanger Christophe , Ader Magali , Sarazin Gerard , Jézéquel Didier , Agogué Hélène , Troussellier Marc , Hugoni Mylène 
Published: October 2023

AbstractMicroorganisms are key contributors of aquatic biogeochemical cycles but their microscale ecology remains largely unexplored, especially interactions occurring between phytoplankton and microorganisms in the phycosphere, that is the region immediately surrounding phytoplankton cells. The current study aimed to provide evidence of the phycosphere taking advantage of a unique hypersaline, hyperalkaline ecosystem, Lake Dziani Dzaha (Mayotte), where two phytoplanktonic species permanently co‐dominate: a cyanobacterium, Arthrospira fusiformis, and a green microalga, Picocystis salinarum. To assay phycospheric microbial diversity from in situ sampling, we set up a flow cytometry cell‐sorting methodology for both phytoplanktonic populations, coupled with metabarcoding and comparative microbiome diversity. We focused on archaeal communities as they represent a non‐negligible part of the phycospheric diversity, however their role is poorly understood. This work is the first which successfully explores in situ archaeal diversity distribution showing contrasted phycospheric compositions, with P. salinarum phycosphere notably enriched in Woesearchaeales OTUs while A. fusiformis phycosphere was enriched in methanogenic lineages affiliated OTUs such as Methanomicrobiales or Methanofastidiosales. Most archaeal OTUs, including Woesearchaeales considered in literature as symbionts, were either ubiquitous or specific of the free‐living microbiome (i.e. present in the 3–0.2 μm fraction). Seminally, several archaeal OTUs were enriched from the free‐living microbiome to the phytoplankton phycospheres, suggesting (i) either the inhibition or decrease of other OTUs, or (ii) the selection of specific OTUs resulting from the physical influence of phytoplanktonic species on surrounding Archaea.
Amazonian colonization from the Atlantic Forest: New perspectives on the connections of South American tropical forests
Authors: Bocalini Fernanda , Bolívar‐Leguizamón Sergio D. , Silveira Luís F. , Bravo Gustavo A. 
Published: October 2023

AbstractAn open and dry vegetation belt separates Amazonia (AM) and the Atlantic Forest (AF). Evidence from palaeoclimatic and phylogenetic studies suggests past connections between these forests during cycles of increased humidity through the formation of forest corridors. The distinctive northern AF avifauna is known to have affinities both with AM and the southern AF. Still, the extent of how these two regions contributed to the assemblage of this avifauna remains poorly understood. Using historical demographic analyses and comparative phylogeography based on sub‐genomic genetic sampling, we assessed how past connections between AM and AF led to shared vicariance and colonization events in four avian AF endemic taxa. Our results supported the occurrence of humid forest corridors promoting the contact between AF and AM populations and suggested two vicariant events and two colonization events from AF to AM. Population divergences were mostly non‐synchronous and occurred multiple times during the Pleistocene. Historical gene flow was prevalent across study groups, supporting migration flows after the initial separation between AM and AF – a pattern previously unknown in birds between these regions. Idiosyncratic histories and divergent demographic syndromes suggest that organisms' responses to climate‐driven habitat shifts broadly depend on their ecological attributes. This study strengthened our knowledge of past connections between AM and AF and provided demographic scenarios amenable for testing in other groups of co‐distributed organisms.
Unmasking microsatellite deceptiveness and debunking hybridization with SNPs in four marine copepod species of Calanus
Authors: Choquet Marvin , Lizano Apollo M. , Le Moan Alan , Ravinet Mark , Dhanasiri Anusha K. S. , Hoarau Galice 
Published: October 2023

AbstractInterspecific hybridization events are on the rise in natural systems due to climate change disrupting species barriers. Across taxa, microsatellites have long been the molecular markers of choice to identify admixed individuals. However, with the advent of high‐throughput sequencing easing the generation of genome‐wide datasets, incorrect reports of hybridization resulting from microsatellite technical artefacts have been uncovered in a growing number of taxa. In the marine zooplankton genus Calanus (Copepoda), whose species are used as climate change indicators, microsatellite markers have suggested hybridization between C. finmarchicus and C. glacialis, while other nuclear markers (InDels) never detected any admixed individuals, leaving the scientific community divided. Here, for the first time, we investigated the potential for hybridization among C. finmarchicus, C. glacialis, C. helgolandicus and C. hyperboreus using two large and independent SNP datasets. These were derived firstly from a protocol of target‐capture applied to 179 individuals collected from 17 sites across the North Atlantic and Arctic Oceans, including sympatric areas, and second from published RNA sequences. All SNP‐based analyses were congruent in showing that Calanus species are distinct and do not appear to hybridize. We then thoroughly re‐assessed the microsatellites showing hybrids, with the support of published transcriptomes, and identified technical issues plaguing eight out of 10 microsatellites, including size homoplasy, paralogy, potential for null alleles and even two primer pairs targeting the same locus. Our study illustrates how deceptive microsatellites can be when applied to the investigation of hybridization.
Primed inflammatory response by fibroblast subset is necessary for proper oral and cutaneous wound healing
Authors: Chen Zhaoxu , Debnath Rahul , Chikelu Ifeoma , Zhou Jonathan X. , Ko Kang I. 
Published: October 2023

AbstractFibroblasts are ubiquitous mesenchymal cells that exhibit considerable molecular and functional heterogeneity. Besides maintaining stromal integrity, oral fibroblast subsets are thought to play an important role in host–microbe interaction during injury repair, which is not well explored in vivo. Here, we characterize a subset of fibroblast lineage labeled by paired‐related homeobox‐1 promoter activity (Prx1Cre+) in oral mucosa and skin and demonstrate these fibroblasts readily respond to microbial products to facilitate the normal wound healing process. Using a reporter mouse model, we determined that Prx1Cre+ fibroblasts had significantly higher expression of toll‐like receptors 2 and 4 compared to other fibroblast populations. In addition, Prx1 immunopositive cells exhibited heightened activation of inflammatory transcription factor NF‐κB during the early wound healing process. At the cytokine level, CXCL1 and CCL2 were significantly upregulated by Prx1Cre+ fibroblasts at baseline and upon LPS stimulation. Importantly, lineage‐specific knockout to prevent NF‐κB activation in Prx1Cre+ fibroblasts drastically impaired both oral and skin wound healing processes, which was linked to reduced macrophage infiltration, failure to resolve inflammation, and clearance of bacteria. Together, our data implicate a pro‐healing role of Prx1‐lineage fibroblasts by facilitating early macrophage recruitment and bacterial clearance.
Use tax administration and revenue production in the states
Authors: Mikesell John L. , Stavick John D. , Ross Justin M. 
Published: October 2023

AbstractUse taxes are utilized by states to discourage taxpayers from engaging in sales tax avoidance via shopping in lower tax states. Enforcement of this tax has long been difficult, as demonstrated in the case of South Dakota v. Wayfair, Inc. (2018). States have instead relied on different administration and tax structures to generate revenues. We contribute to the limited existing use tax literature by studying a panel of use tax revenues collected from 25 states, as well as use tax collection methods states implement for individual and business taxpayers. States are best at enforcing the use tax where they can rely on complementary administrative tax collection systems, such as in business‐to‐business transactions. They will likely struggle to realize improved use tax compliance for household consumption even in the wake of the Wayfair ruling.