bluuebunny/crossref_metadata_2025_split huggingface dataset:
MODPATH‐RW: A Random Walk Particle Tracking Code for Solute Transport in Heterogeneous Aquifers
Authors: Pérez‐Illanes Rodrigo , Fernàndez‐Garcia Daniel 
Published: January 2024

AbstractRandom walk particle tracking (RWPT) is a discrete particle method that offers several advantages for simulating solute transport in heterogeneous geological systems. The formulation is a discrete solution to the advection‐dispersion equation, yielding results that are not influenced by grid‐related numerical dispersion. Numerical dispersion impacts the magnitude of concentrations and gradients obtained from classical grid‐based solvers in advection‐dominated problems with relatively large grid Péclet numbers. Accurate predictions of concentrations are crucial for reactive transport studies, and RWPT has been recognized for its potential benefits for this kind of application. This highlights the need for a solute transport program based on RWPT that can be seamlessly integrated with industry‐standard groundwater flow models. This article presents a solute transport code that implements the RWPT method by extension of the particle tracking model MODPATH, which provides the base infrastructure for interacting with several variants of MODFLOW groundwater flow models. The implementation is achieved by developing a method for determining the exact cell‐exit position of a particle undergoing simultaneous advection and dispersion, allowing for the sequential transfer of particles between flow model cells. The program is compatible with rectangular unstructured grids and integrates a module for the smoothed reconstruction of concentrations. In addition, the program incorporates parallel processing of particles using the OpenMP library, enabling faster simulations of solute transport in heterogeneous systems. Numerical test cases involving different applications in hydrogeology benchmark the RWPT model with well‐known transport codes.
Exploratory prospective, randomized phase II study of neoadjuvant transcatheter arterial chemoembolization plus surgery versus surgery alone for large hepatocellular carcinoma (CSGO‐HBP‐005): Clinical Study Group of Osaka University, Hepato‐Biliary‐Pancreatic Group
Authors: Kobayashi Shogo , Tomokuni Akira , Takeda Yutaka , Wada Hiroshi , Katsura Yoshiteru , Hashimoto Kazuhiko , Tomimaru Yoshito , Asaoka Tadafumi , Yamada Terumasa , Tsujie Masanori , Noda Takehiro , Morita Satoshi , Nagano Hiroaki , Mori Masaki , Doki Yuichiro , Eguchi Hidetoshi ,   the Clinical Study Group of Osaka University, Hepato‐Biliary‐Pancreatic Group
Published: January 2024

AbstractAimNeoadjuvant transcatheter arterial chemoembolization (TACE) for large tumors is controversial, especially in the minimally invasive surgery era. The aim of this study was to compare features between groups treated with neoadjuvant TACE followed by surgery (TACE + surgery) or upfront surgery for hepatocellular carcinoma >5 cm.MethodsIn this exploratory, multicenter, randomized phase I study, the primary measure was 2‐year disease‐free survival (DFS). Secondary measures were resection rate, necrosis rate by TACE, 2‐year overall survival, and site of recurrence. A total of 30 patients were randomly allocated to each arm.ResultsThe two arms did not differ in patient characteristics. The median time to surgery from randomization was 48 days for TACE + surgery and 29 for surgery only (p < 0.001). Postoperative morbidities did not differ between arms. The 2‐year DFS, overall survival, and resection rates were 56.7%, 80.0%, and 93.3%, respectively, in the TACE + surgery arm, and 56.1%, 89.9%, and 90.0% in the upfront surgery arm. Minimally invasive surgery was carried out in 35.7% in the TACE + surgery arm and in 29.6% in the upfront surgery arm. The median necrosis rate by TACE was 90.0%. In resected specimens, invasion to the hepatic vein was less with TACE + surgery (3.6% vs. 22.2%, p = 0.0380). In cases of 100% necrosis with TACE, 2‐year DFS was 100%. Site of recurrence did not differ between groups.ConclusionNeoadjuvant TACE did not improve 2‐year DFS, and neoadjuvant TACE allowed delay of surgical treatment without increased morbidity and cancer progress.Clinical trial registrationUMIN: 000005241.
Rev‐erbα attenuates refractory periapical periodontitis via M1 polarization: An in vitro and in vivo study
Authors: Song W. , Ye L. , Tang Q. , Lu X. , Huang X. , Xie M. , Yu S. , Yuan Z. , Chen L. 
Published: January 2024

AbstractAimRev‐erbα has been reported to regulate the healing of inflammatory lesions through its effect on the immune system in a variety of inflammatory disease. Moreover, the balance of macrophages polarization plays a crucial role in immune response and inflammatory progression. However, in refractory periapical periodontitis (RAP), the role of Rev‐erbα in inflammatory response and bone resorption by regulating macrophage polarization remains unclarified. The aims of the present study were to investigate the expression of Rev‐erbα in experimental RAP and to explore the relationship between Rev‐erbα and macrophage polarization through the application of its pharmacological agonist SR9009 into the in vivo and in vitro experiments.MethodologyEnterococcus faecalis‐induced RAP models were established in SD rats. Histological staining and micro‐computed tomography scanning were used to evaluate osteoclastogenesis and alveolar bone resorption. The expression of Rev‐erbα and macrophage polarization were detected in the periapical tissues from rats by immunofluorescence, flow cytometry, and western blots. Furthermore, immunohistochemical staining and enzyme‐linked immunosorbent assay were performed to explore the relationship between Rev‐erbα and inflammatory cytokines related to macrophage polarization.ResultCompared to healthy periapical tissue, the expression of Rev‐erbα was significantly down‐regulated in macrophages from inflammatory periapical area, especially in Enterococcus faecalis‐induced periapical lesions, with obvious type‐1 macrophage (M1)‐like dominance and the production of pro‐inflammatory cytokines. In addition, Rev‐erbα activation by SR9009 could induce type‐2 macrophage (M2)‐like polarization in periapical tissue and THP1 cell line, followed by increased secretion of anti‐inflammatory cytokines IL‐10 and TGF‐β. Furthermore, intracanal application of SR9009 reduced the lesion size and promoted the repair of RAP by decreasing the number of osteoclasts and enhancing the formation of mineralized tissue in periapical inflammatory lesions.ConclusionsRev‐erbα played an essential role in the pathogenesis of RAP through its effect on macrophage polarization. Targeting Rev‐erbα might be a promising and prospective therapy method for the prevention and management of RAP.
Dynamic capabilities measurement safari: A roadmap
Authors: Bruyaka Olga , Prange Christiane , Li Hua Ariel 
Published: January 2024

AbstractLack of transparency about conceptual and measurement choices in empirical studies on dynamic capabilities (DCs) amplifies difficulties scholars face on the road to conducting high‐quality quantitative research. Building on the best practices of construct operationalization developed in the organizational research methods literature, we review 18 review studies on DCs research and conduct our own review of 185 quantitative studies published in 1994–2022 through the lens of an auxiliary theory development that formalizes and structures the process of translating a concept into a measurable construct. The present paper draws scholars’ attention to the importance of carefully choosing DCs measurement models as a consequential decision in DCs operationalization, which complements existing studies that either reviewed DCs conceptualizations or developed scales and measures of DCs. Besides providing scholars with an up‐to‐date map of quantitative research on DCs, our paper includes recommendations for consistent operationalization of DCs and identifies best operationalization practices in DCs quantitative research. Overall, the present paper advances DCs research by clarifying the construct of DCs, which is especially pertinent for future research in this area as it should strive towards robust advancement.
Effects of processing conditions on flash sintering of commercial ZrN
Authors: Eskandariyun Amirali , Das Suprabha , Dubois Diego , Saeedian Kiyana , Durygin Andriy , Drozd Vadym , Cheng Zhe 
Published: January 2024

AbstractFlash sintering (FS) is a potentially rapid and low‐cost manufacturing technique for advanced ceramics. There are still many unknowns about ceramic FS, especially for highly conductive high‐temperature ceramics (HTC), which often display decreased bulk conductivity with increasing temperature. This study qualitatively characterizes the flash behavior of highly conductive HTC materials using zirconium nitride (ZrN) as an example. The effects of processing parameters (e.g., DC voltage/electrical field strength, voltage ramp rate, post‐flash holding time, mechanical pressure, sample milling, and choice of electrode materials) on ZrN flash behavior are also qualitatively studied and linked to samples microstructure and hardness. It is observed that best densification was achieved using 5 min Spex‐milled ZrN powder under 25 MPa of applied pressure and constant 8 V DC. The potential mechanism for ZrN FS and the similarity and difference from FS of conventional oxides like YSZ have been proposed based on experimental observations, and the directions for future research are also pointed out.
Tunable emission of Ce3+ in (K, Rb)3GdSi2O7 phosphors toward broadband cyan luminescence
Authors: Li Jiawen , Huang Feifei , Hua Youjie , Li Bingpeng , Xu Shiqing , Lei Ruoshan 
Published: January 2024

AbstractIn an effort to obtain a novel cyan‐emitting phosphor, the [K1‐xRbx]3GdSi2O7: yCe3+ materials (x = 0, 0.1, 0.2, 0.3, 0.4, y = 0, 0.005, 0.01, 0.02, 0.03, 0.04) are synthesized via a solid‐state reaction pathway, and their crystal structure and luminescence behaviors are studied systematically. The chemical substitution of Rb+ in the K+ sites can enlarge the K3GdSi2O7 host lattice and help to the blue‐shifting of emission band of Ce3+ ions due to the decreased crystal field splitting effect. It is also confirmed that the Ce3+ ions tend to enter [Gd1O6] and [Gd2O6] polyhedrons simultaneously. Consequently, the [K0.7Rb0.3]3GdSi2O7: Ce3+ phosphor yields a broadband cyan emission centered at 492 nm with the full width at half maximum (FWHM) of ∼115 nm upon 365 nm excitation. The optimal concentration of Ce3+ dopant is determined to be 0.01, and the concentration quenching effect can be attributed to the dipole−dipole interactions. The white light emitting diode (WLED) device fabricated by employing the discovered [K0.7Rb0.3]3GdSi2O7: 0.01Ce3+ phosphor displays a high color rendering index (Ra = 91.7) and a low correlated color temperature (CCT = 3749 K). This work may promote the development of cyan phosphors for near ultraviolet‐converted WLEDs with high performance.
Climatic‐niche breadth, niche position, and speciation in lizards and snakes
Authors: Moreira Matthew Owen , Wiens John J. , Fonseca Carlos , Rojas Danny 
Published: January 2024

AbstractAimThe climatic niche is associated with diversification in many groups of animals and plants. However, the relationships between climatic‐niche breadth evolution, climatic‐niche position evolution, and speciation remain underexplored. It is particularly unclear whether changes in climatic‐niche breadth are related to diversification. We tested two hypotheses relating niche breadth, niche position, and speciation using climatic data in Squamata (lizards and snakes), one of the largest radiations of tetrapods. These hypotheses were: (1) the oscillation hypothesis (niche breadth changes along with niche position and speciation) and (2) the musical‐chairs hypothesis (niche breadth remains relatively constant when niche position changes during speciation).LocationGlobal.TaxonSquamata (lizards and snakes).MethodsWe estimated rates of speciation and evolutionary rates for both climatic‐niche position and climatic‐niche breadth for 5320 squamate species. We tested relationships among these rates using Bayesian phylogenetic generalised linear‐mixed models.ResultsHigher speciation rates were associated with higher rates of evolution in niche position and in niche breadth. Faster rates of change in niche breadth were related to narrower niches and faster rates of change in niche position.Main ConclusionsOur results support the oscillation hypothesis to explain the relationships between speciation and changes in climatic‐niche position and climatic‐niche breadth. We found that species that changed climatic‐niche breadths more rapidly: (1) speciated faster; (2) evolved towards narrower niche breadths; and (3) changed climatic‐niche positions more rapidly. These results suggest that oscillation between wider and narrower niches is coupled with climatic‐niche divergence and speciation. These conclusions may apply to many other groups of plants and animals in which speciation is often related to climatic‐niche divergence.
Unravelling the heterogeneity of oral squamous cell carcinoma by integrative analysis of single‐cell and bulk transcriptome data
Authors: Li Jia , Li Shengjiao , Shu Mingyang , Hu Weiwei 
Published: January 2024

AbstractOral squamous cell carcinoma (OSCC) is a prevalent malignancy of the head and neck with rising global incidence. Despite advances in treatment modalities, OSCC prognosis remains diverse due to the complex molecular and cellular heterogeneity within tumours, as well as the heterogeneity in tumour microenvironment (TME). In this study, we utilized single‐cell RNA sequencing (scRNA‐seq) analysis to explore distinct subpopulations of tumour cells in OSCC tissues and their interaction with components in TME. We identified four major tumour cell subpopulations (C0, C1, C2 and C3) with unique molecular characteristics and functional features. Pathway enrichment analysis revealed that C0 primarily expressed genes involved in extracellular matrix interactions and C1 showed higher proliferation levels, suggesting that the two cell subpopulations exhibited tumour aggressiveness. Conversely, C2 and C3 displayed features associated with keratinization and cornified envelope formation. Accordingly, C0 and C1 subpopulations were associated with shorter overall and disease‐free survival times, while C2 and C3 were weakly correlated with longer survival. Genomic analysis showed that C1 demonstrated a positive correlation with tumour mutation burden. Furthermore, C0 exhibited resistant to cisplatin treatment, while C1 showed more sensitive to cisplatin treatment, indicating that C0 might exhibit more aggressive compared to C1. Additionally, C0 had a higher level of communication with fibroblasts and endothelial cells in TME via integrin‐MAPK signalling, suggesting that the function of C0 was maintained by that pathway. In summary, this study provided critical insights into the molecular and cellular heterogeneity of OSCC, with potential implications for prognosis prediction and personalized therapeutic approaches.
Health‐related quality of life and its influencing factors in patients with primary cutaneous B‐cell lymphomas: A multicentric study in 100 patients
Authors: Schirren A. E. C. , Albrecht J. D. , Melchers S. , Weiß C. , Büttner S. , Dippel E. , Gosmann J. , Jonak C. , Klemke C.‐D. , Laturnus‐Chang M. , Livingstone E. , Mitteldorf C. , Schummer P. , Stadler R. , Stranzenbach R. , Weyer‐Fahlbusch S. S. , Wobser M. , Ziemer M. , Nicolay J. P. 
Published: January 2024

AbstractBackgroundPrimary cutaneous B‐cell lymphomas (CBCL) are a group of rare malignant skin diseases that represent approximately 20%–30% of all primary cutaneous lymphomas (PCL). Previous studies revealed impaired health‐related quality of life (HRQoL) in patients diagnosed with primary cutaneous T‐cell lymphoma (CTCL). Currently, only small‐sized studies investigated HRQoL in CBCL patients and lacked detailed analysis of respective subtypes.ObjectivesThis study aims to investigate HRQoL in CBCL patients to identify independent factors of HRQoL impairment in CBCL patients.MethodsOne hundred CBCL patients were recruited from eight German PCL centres in this multicentric, cross‐sectional study from 2021 to 2022. The patients completed the dermatologic HRQoL questionnaire Skindex‐29 and an investigator‐designed ‘CBCL‐Questionnaire’ with additional questions on HRQoL and clinical characteristics.ResultsThe Skindex‐29 revealed that HRQoL in CBCL patients is impaired on a mild to moderate level. The multiple regression analysis identified parameters like worries about dying, feeling prejudiced/discriminated and impairment of daily activities to be independently associated with impairment of HRQoL. Highest scores for HRQoL impairment were found in patients with primary cutaneous follicle centre lymphoma while on rituximab treatment and in patients with primary cutaneous marginal zone lymphoma while on watchful waiting.ConclusionsHRQoL is impaired in CBCL patients, even though, in the face of indolent disease course and favourable prognosis in the majority of cases. Of note, our investigator‐designed tool identified worries about dying, feeling prejudiced/discriminated, and the type of treatment to have a negative impact on patients' HRQoL. Our study highlights the importance of a thorough patient–doctor communication to capture overall disease burden because generic HRQoL tools might lack of disease‐specific items.
Otolith sectioning reveals higher maximum age in greater weever (Trachinus draco)
Authors: Mion Monica , Orio Alessandro , Lövgren Johan , Vitale Francesca , Cardinale Massimiliano 
Published: January 2024

AbstractGrowth and maximum age are two key parameters that inform resilience of fish populations to exploitation. Existing information on those for greater weever inhabiting the eastern North Sea is based on the analysis of whole otoliths. Here, we present a reanalysis using sectioned otoliths. The results reveal a different growth pattern and a higher maximum age than that previously reported. The higher maximum age makes greater weever populations more vulnerable to exploitation. Such information can serve as a basis for the estimation of the growth curve that can be used for future assessment of the species.
Clin‐STAR corner: Practice‐changing advances at the interface of surgery and geriatrics
Authors: Jones Teresa S. , Peters Xane , Robinson Thomas N. 
Published: January 2024

AbstractOlder adults who undergo major operations are at high risk for complications, disability, and death. The physio‐social compromises unique to older adults are not routinely assessed and managed in the perioperative setting. Currently, the most practice‐changing topic nationally in geriatric surgery is the implementation of comprehensive, multidisciplinary geriatric care pathways to provide age‐friendly care for older adults throughout their perioperative course. This review presents three recently published articles focused on defining evidence‐based outcomes associated with implementation of a comprehensive geriatric surgery program for older adults undergoing major inpatient operations. These studies serve as the initial evidence evaluating the efficacy and effectiveness of comprehensive perioperative geriatric surgery programs. Each study was chosen due to their high potential for meaningful impact for both clinicians and healthcare systems looking to improve their surgical care of older adults.
Native collagen sheet mask improves skin health and appearance: A comprehensive clinical evaluation
Authors: Janssens‐Böcker Ciska , Wiesweg Karin , Doberenz Claudia 
Published: January 2024

AbstractBackgroundCollagen, a critical structural protein found abundantly in animal skin and bones, has become increasingly recognized for its potential therapeutic role in skincare. Despite growing interest, the scientific evidence for the efficacy of collagen sheet masks remains limited. The principal objective of our study was to provide insights into the multifaceted role of collagen in skin health, with a specific focus on its application in collagen sheet masks.MethodsThe effects of a collagen sheet mask consisting of >92% native bovine collagen were investigated. The soluble protein components of the collagen matrix were analyzed and the influence of soluble collagen components on fibroblast regulation was examined. Scanning Electron Microscope (SEM) analysis was performed for structural analysis and effect on irritated skin. Five different clinical studies were conducted, including a comparison of the diversity of the skin microbiome, the tolerance and local irritating reactions in atopic dermatitis, an evaluation of skin redness after UV radiation, wrinkle reduction, and hydration and skin roughness of the collagen mask in comparison to a pre‐soaked cellulose sheet mask.ResultsThe collagen mask contains soluble protein components, including small collagen peptides. The mask showed potential for promoting fibroblast activity. SEM analysis showed a native collagen structure similar to human dermis. The mask maintained the skin microbiome diversity and decreased skin pH levels. It demonstrated good tolerability on both intact and lesional skin and had a significant effect in reducing erythema caused by UV radiation compared to other skincare products. It showed significant improvements in skin hydration and the volume of eye wrinkles and was more effective than pre‐soaked cellulose sheet masks.ConclusionCollagen sheet masks have the potential to positively impact skin health and appearance by increasing hydration, reducing erythema, minimizing wrinkles, and maintaining a healthy skin microbiome and skin barrier.
Multiple Bowen's disease due to long‐term narrow‐band ultraviolet B phototherapy: A case report and literature review
Authors: Zhang Dong , Fan Huiping , Liu Xuankai , Wang Shuai , Lang Xiaoqiao , Ma Weiyuan , Pang Yunyan 
Published: January 2024

AbstractObjectiveBy presenting a case study on multiple instances of Bowen's disease and the consistent use of narrow‐band ultraviolet B (NB‐UVB) phototherapy over a three‐year period, our aim is to enhance the comprehension of domestic clinicians regarding the disease. Additionally, we seek to review existing literature, encouraging dermatologists to consider clinical secondary primary lesion diagnoses.MethodOur approach involves analyzing a diagnosed case of multiple Bowen's disease, examining clinical manifestations, histopathology, imaging results, and treatment methods related to NB‐UVB phototherapy. We aim to facilitate discussion and understanding through a comprehensive literature analysis.ResultsAn elderly male with a 30‐year history of psoriasis vulgaris initiated continuous NB‐UVB therapy three years ago. A year later, he developed red patches and plaques with distinct borders and scaly surfaces on his face, trunk, lower extremities, and scrotum. Histopathological examination confirmed Bowen's disease. Treatment involved liquid nitrogen cryotherapy, with no recurrence observed during the one‐year follow‐up.ConclusionThis case highlights that Bowen's disease, typically solitary, can manifest as multiple instances, especially in individuals with a history of psoriasis vulgaris. While NB‐UVB stands as the primary treatment for psoriasis vulgaris, caution is warranted due to the potential risk of skin tumor induction with prolonged high‐dose usage. Clinicians should be vigilant in monitoring and assessing the long‐term implications of such therapies.