bluuebunny/crossref_metadata_2025_split huggingface dataset:
Tenofovir Disoproxil Fumarate Versus Entecavir: Effects on Lipid Profiles and Cardiovascular Outcomes in People Living With Chronic Hepatitis B
Authors: Kim Log Young , Kim Jae Young , Yoo Jeong‐Ju , Kim Sang Gyune , Kim Young‐Seok 
Published: January 2025

ABSTRACTWhile entecavir (ETV) and tenofovir disoproxil fumarate (TDF) effectively manage chronic hepatitis B, their long‐term effects on lipid metabolism and cardiovascular outcomes remain unclear. This study compares the impact of ETV, TDF, and treatment‐naïve (control group) on hyperlipidemia and major adverse cardiac events (MACE) in people living with chronic hepatitis B (PLWHB). We used claim data from the South Korean National Health Insurance Service. Propensity score matching was used to account for confounding factors. The 5‐year cumulative incidence of dyslipidemia was 7.10% for TDF, 12.17% for ETV, and 18.55% for the control group, with incidence rates per 1000 person‐years of 14.5, 25.5, and 38.9, respectively. TDF showed a significantly lower risk of dyslipidemia compared to ETV (IRR: 0.56, p < 0.001) and the control group, which was confirmed in Cox regression analysis (HR: 0.392 vs. control, p < 0.001). For MACE, the 5‐year cumulative incidence was 9.11% for TDF, 10.98% for ETV, and 12.32% for the control group, with incidence rates per 1000 person‐years of 18.4, 22.5, and 24.8, respectively. TDF demonstrated a reduced risk compared to ETV (IRR: 0.817, p < 0.001), which was similarly supported by Cox regression analysis (HR: 0.728 vs. control, p < 0.001). In conclusion, TDF not only reduces the risk of hyperlipidemia but is also associated with a reduced risk of MACE compared to ETV or treatment‐naive group in PLWHB.
Low Neutralization of SARS‐CoV‐2 Omicron BA5248, XBB15 and JN1 by Homologous Booster and Breakthrough Infection
Authors: Li Jianhua , Yan Hao , Li Jiaxuan , Ling Feng , Feng Yan , Mao Haiyan , Wang Xingxing , Li Xiaoyan , Song Wanchen , Wu Guangshang , Zhang Yanjun , Chen Yin , Chen Keda 
Published: January 2025

ABSTRACTImmunity against Severe Acute Respiratory Syndrome Coronavirus 2 (SARS‐CoV‐2) can be induced through either infection with the virus or vaccination, providing protection against reinfection or reducing the risk of severe clinical outcomes. In this study, we recruited 172 volunteers who received different vaccination regimens, including 124 individuals who had recovered from breakthrough infections caused by the Omicron variant (27 with 2 doses, 49 with 3 doses, and 48 with 4 doses) and 48 healthy donors who did not experience breakthrough infections (all of whom received a fourth dose during the infection wave). We measured neutralizing antibody levels against Omicron BA.5.2.48, XBB.1.5, and JN.1 and found no significant differences in neutralizing antibody titers between natural infection and homologous booster vaccination at 6 months (p > 0.05), with geometric mean titers declining by over 100‐fold for some variants relative to the prototype strain.
Hotspots and global trends in research of host immune response in periodontitis: A bibliometric analysis
Authors: Huamán‐Mendoza Aldrin André , Pantigozo‐Morán Fabiola Lucía , da Silva José Carlos , Chuquimez‐Ventura Casimira Valeria , Holzhausen Marinella 
Published: January 2025

AbstractBackgroundThe host immune response plays a major role in the pathogenesis of periodontitis. A bibliometric study can be crucial to understanding the different processes involved in this area; however, to our knowledge, it has not been published until now. Therefore, a bibliometric analysis was conducted to assess research hotspots and global trends in scientific articles about the immune response in periodontitis published between 1952 and 2023.MethodsThe search strategy was defined using keywords and Boolean operators. The Web of Science Core Collection database was used. In addition, the bibliometric analysis was performed using four tools: Python 3.12, VOSviewer 1.6.19, R‐Bibliometrix, and CiteSpace.ResultsA total of 7696 articles were included, comprising 6691 regular articles and 1005 review articles. Data analysis revealed an increasing trend in the number of publications over the years in this field, with the most cited article written by Preshaw et al. (2012). Leading countries in article production include the United States, China, Japan, and Brazil. Regarding institutions, the University of Helsinki had the highest number of publications (N = 339), with one of its researchers being the author with the most publications (Dr. Sorsa, N = 143, H‐index = 52). Concerning journals, the Journal of Periodontology was the most influential journal. Finally, recent trending topics in research were related to the influence of inflammation on dysbiosis, immune biomarkers, immunomodulation, and the impact of aging on immunocompetence.ConclusionThis bibliometric study demonstrated a growing interest and the emergence of new trends in research on host immune response in periodontitis.
NP‐bioTech: a circular economy approach to catalyst‐based biostabilization of citrus processing waste
Authors: Nardo Fabrizio , Piras Andrea , Bullitta Simonetta , Ledda Luigi , Serralutzu Francesca 
Published: January 2025

AbstractBACKGROUNDBiowaste accounts for about 40% of total waste. Food‐industry waste is one major biowaste stream. The available technological approaches to biowaste treatment are expensive, not circular, unsustainable, and they require pre‐treatments such as dehydration, extraction of inhibitors, pH correction, or the addition of other organic matrices. The NP‐bioTech process uses a biocatalyst adsorbed onto an inert material enabling accelerated fermentation of critical biomass without pre‐treatments, transforming it into biostabilized and pasteurized material, and converting waste into new usable products rapidly. Biocatalysts consist of naturally fortified selections of microbial colonies, enzymes, and fungi that are resistant to the action of d‐limonene and other fermentation inhibitors.RESULTSThe NP‐bioTech process was able to activate vigorous fermentation of citrus waste without any of the pre‐treatments required by other available biowaste‐treatment technologies. The horticultural use of the biostabilized output of such process for greenhouse crops was verified. The addition of such output to the growth media was beneficial for plants and did not show negative effects on quality and yield of tomatoes (Lycopersicon esculentum L.). The concentration of Ca, K, Zn, Fe, and polyphenol increased; the average number of berries per plant was improved; the concentration of Pb and Cd contaminants decreased.CONCLUSIONThe NP‐bioTech process emits no odors or pollutants. It does not generate leachate, and its output can be used in agriculture. It is capable of reconciling compliance with strict environmental restrictions, industrial feasibility, and economic sustainability. Its potential impact thus aligns well with the circular economy model. © 2025 Society of Chemical Industry.
The Current State of Perioperative Chemotherapy in Resectable Colorectal Liver Metastases: A Narrative Review
Authors: Trehub Yevhenii , Malovanna Anna , Zemskov Sergii 
Published: January 2025

ABSTRACTPerioperative chemotherapy has emerged as a critical component in managing resectable colorectal liver metastases (CRLM), aiming to improve long‐term survival, although data supporting its use remains controversial. This narrative review explores the current state of perioperative chemotherapy in patients with resectable CRLM, focusing on its role in different oncological risk categories. The review highlights ongoing controversies, such as optimal patient selection and the role of post‐ versus preoperative treatment in specific scenarios.
Prolonged Vancomycin‐Induced Linear IgA Disease in a Patient With Renal Failure
Authors: Takezawa Kaori , Noborio Reiko , Nomura Yuki , Kiyohara Takahiro , Mine Mako , Hashimoto Takashi 
Published: January 2025

ABSTRACTA 64‐year‐old man with pneumococcal septic shock and subsequent renal failure underwent treatments with antibiotics including intravenous vancomycin (VCM). Blistering skin lesions appeared 10 days after the initiation of VCM. When the patient was transferred to us 5 months later, blisters with erythema were still observed on the abdomen and thighs. Histopathological examination revealed subepidermal blister with infiltration of eosinophils and neutrophils, and direct immunofluorescence revealed linear IgA deposition at the basement membrane zone. The diagnosis of linear IgA disease (LAD)was made, and drug‐induced LAD by VCM was suspected, because of the episode of the blister development 10 days after the first VCM administration. Although the results of various sero‐immunological tests were negative, IgA reactivity with type Ⅶ collagen was detected by VCM‐treated ELISA, which further suggested the diagnosis of VCM‐induced LAD. The possible mechanism for the prolonged disease course was speculated.
Histological Type‐Specific Behavior in Sarcomas: Analysis of Head and Neck Cancer Registry of Japan
Authors: Kobayashi Kenya , Yoshimoto Seiichi , Yamamura Koji , Kitayama Megumi , Kawakita Daisuke , Nibu Ken‐Ichi , Kondo Kenji , Saito Yuki 
Published: January 2025

ObjectiveThe goal of this study was to better understand the epidemiology, clinical characteristics, and treatment outcomes of head and neck sarcomas using real‐world data from Japan.MethodsUsing the Japanese Head and Neck Cancer Registry, we identified 438 patients who were pathologically diagnosed with head and neck sarcoma between 2011 and 2020. We compared epidemiological, clinical, and prognostic data for the different histological types of sarcoma.ResultsThe top five most common histopathological types were rhabdomyosarcoma, osteosarcoma, chondrosarcoma, leiomyosarcoma, and liposarcoma. The most common primary sites were the nasal cavity and paranasal sinuses. The overall cohort had clinical, pathologic, and occult lymph node positivity rate (OLR) of 18%, 15%, and 2%, respectively. Clinical lymph node positivity was highest in rhabdomyosarcoma (46%), followed by angiosarcoma (26%), with leiomyosarcoma, chondrosarcoma, and liposarcoma accounting for less than 10%. The 3‐year overall survival rate was 74.8% among the 147 patients with available prognostic information. The histological type with the lowest 3‐year overall survival was undifferentiated pleomorphic sarcoma (54%), followed by leiomyosarcoma (65%), and angiosarcoma (69%). In six of seven histological types, the 3‐year locoregional‐free survival rate was less than 70%.ConclusionSarcomas of the head and neck most commonly occur in the nasal cavity and paranasal sinuses. The prevalent histological type depended on the primary site. Rhabdomyosarcoma and angiosarcoma are histological types with a high risk of cervical metastasis. In the head and neck region, there are numerous histological types many of which lack local control.Level of EvidenceLevel 3 Laryngoscope, 2025
Kill Two Birds With One Stone? China's Mixed Ownership Reform and Investment Efficiency
Authors: Ren Liying , Wu Haomin , Liu Yangyang 
Published: January 2025

ABSTRACTThe reform of state‐owned enterprises (SOEs) is a major strategic step for the central government to implement the policy of strengthening and expanding SOEs and an important measure to support the development of the nonpublic economy. This has become the main direction of China's current reform and the focus of its governance. Mixed ownership reform is the key implementation path and main direction of SOE reform. Its fundamental purpose is to stimulate the vitality and competitiveness of these enterprises. Taking the sample of Chinese A‐share‐listed firms from 2004 to 2022, we aimed to explore the impact and mechanism of the mixed ownership reform of SOEs on the investment efficiency of SOEs and participating private enterprises (PEs). We found that the SOEs' mixed ownership reform provides a win–win situation for both SOEs and PEs. Specifically, the incorporation of non–state‐owned capital owed by PEs prevents SOEs' overinvestment, which is denoted as the “direct effect.” Meanwhile, PEs' participation in the reform leads to a reduction in underinvestment, which is denoted as the “indirect effect.” Mechanism analysis indicated that for SOEs, the reform leads to a decreased level of government intervention and a reduced principal agency cost, showing the reform's “governance effect.” For PEs, participation in the reform leads to reduced financing constraints, demonstrating the reform's “resource effect.” This study not only enriches the relevant research on the consequences of mixed ownership reform at the microlevel but also provides valuable experience and reference for the economic reform of emerging markets and developing countries.
Nonlinear SchröDinger Equation for Broad Bandwidth Interfacial Waves With a Current Jump
Authors: Manna Shibam , Dhar A. K. 
Published: January 2025

ABSTRACTEmploying multiscale expansion, a modified nonlinear Schrödinger equation (NSE) of interfacial gravity waves for broad bandwidth in a two‐layer fluid of infinite depths with uniform velocity of the upper fluid has been developed. This NSE is widened by slackening the narrow bandwidth constraint with the purpose that it will be more appropriate for utilization to a realistic sea‐wave spectrum. The main results of this work are (a) to find the effect of wind velocity on the wave profiles and the modulational instability regions and (b) to discuss how the broad wave bandwidth affects on the stability results. On the basis of broad and narrow bandwidth equations, the instability regions in the wave numbers plane and the growth rate of instability curves against wave number for Stokes waves are drawn for several values of the dimensionless speed of the upper layer and the wave steepness. The key feature of this problem is that the new equation due to broad bandwidth is observed to predict the instability region in an excellent agreement with the exact results and due to sufficient bandwidth, this broad‐banded equation is expected to be more appropriate for realistic ocean wave problems.
Fixed Point Results of F$$ F $$‐Contractive–Type Operators With Applications
Authors: Shehu Shagari Mohammed , Ogbumba Rosemary O. , Noorwali Maha , Alotaibi Trad , Saliu Afis 
Published: January 2025

ABSTRACTThis paper adopts new recent techniques for examining fixed point results in ‐metric space to introduce a novel idea termed as hybrid‐interpolative Reich‐Istrescu–type (‐‐)‐contraction. Wherefore, some new invariant point notions that cannot be derived from their cognate ones in both metric and quasi metric spaces are analyzed. To support the results acquired, an illustrative, comparable example is provided. From the viewpoint of application, the existence and distinctiveness of a solution to a mixed integral equation of Volterra‐Fredholm type is examined. A numerical example is also given to show the utility of the obtained results in discussing solvability criteria of the examined fixed point problem.
Generalized Hilbert Operator Acting Between Bergman Spaces
Authors: Tang Pengcheng , Zhang Xuejun 
Published: January 2025

ABSTRACTLet be a positive Borel measure on and . For , the generalized Hilbert operator is defined as follows:
where, for denotes the th moment of the measure , and . In this paper, we characterize the measures for which is a bounded operator acting from Bergman space into . We determine the Hilbert–Schmidt class on for all . In addition, we also study the boundedness (resp. compactness) of acting from to the Bloch space.
Study on Composition Operators Connected With the Laguerre Polynomials
Authors: Gupta Vijay , Violeta Muraru Carmen , Mihai Birou Marius 
Published: January 2025

ABSTRACTA new variant of discrete operators based on the associated (modified) Laguerre polynomials was introduced by Gupta. In the present paper, some direct convergence results for such operators are studied, including a Voronovskaja type result. Some approximation properties were established in weighted spaces, in terms of weighted modulus of continuity.
Fish Oil's Preventive Effect on Two‐Stage Skin Carcinogenesis in Swiss Albino Mice: Involvement of NF‐ҝB Pathways and Oxidative Stress in a Dose‐ and Route Dependent Manner
Authors: Cheniti Hayeme , Kadi Assia , Agred Rym , Kadi Yacine , Djeradi Meriem Khadidja , Melliti Hanane , Chiheb Nadia , Kherfi Hind , Messarah Mahfoud 
Published: January 2025

ABSTRACTThis study investigated the chemopreventive mechanisms of fish oil (FO) at different doses and administration routes in skin carcinogenesis induced by 7,12‐dimethylbenz[a]anthracene (DMBA) and croton oil (CO) in Swiss albino mice. Seventy mice were divided into 10 groups, including controls and those receiving FO either orally or topically, with or without the carcinogenesis protocol. Warts were morphologically analyzed. Anatomopathological analysis, qRT‐PCR of nuclear factor kappa B (NF‐қB) subunits' gene expression, and evaluation of oxidative parameters were conducted. Anatomopathological analysis revealed a presence of invasive squamous cell carcinoma (SCC) in DMBA group. Both oral (500 mg/kg/day) and topical FO treatment showed no signs of cancer, while oral administration at 50 mg/kg/day had no therapeutic effect, and 250 mg/kg/day resulted in low‐grade malignancy. Both oral (250 and 500 mg/kg/day) and topical FO significantly reduced NF‐кB1 gene expression, alleviated oxidative stress markers, and restored antioxidant enzyme activities compared to the DMBA group. FO shows dose‐dependent chemopreventive effects, with oral administration potentially as effective as topical application when using an appropriate dosage. The development of SCC is linked to the stress status and the upregulation of the canonical NF‐κB pathway, while FO's chemoprotective effects likely result from its downregulation.
Nexus: A versatile console for advanced low‐field MRI
Authors: Schote David , Silemek Berk , O'Reilly Thomas , Seifert Frank , Assmy Jan‐Lukas , Kolbitsch Christoph , Webb Andrew G. , Winter Lukas 
Published: January 2025

AbstractPurposeTo develop a low‐cost, high‐performance, versatile, open‐source console for low‐field MRI applications that can integrate a multitude of different auxiliary sensors.MethodsA new MR console was realized with four transmission and eight reception channels. The interface cards for signal transmission and reception are installed in PCI Express slots, allowing console integration in a commercial PC rack. Following standards developed by the MRI community, we implemented an open‐source console software package with native Pulseq and ISMRM raw data support. It is implemented in Python to allow easy customization and provide the flexible use of a freely configurable number of transmit and receive channels. We benchmarked the system by comparing the imaging quality with a state‐of‐the‐art reference system. Different examples of how auxiliary sensors, connected via additional channels, can improve imaging are demonstrated.ResultsUsing a three‐dimensional turbo spin‐echo sequence, image quality of proton density–weighted and T2‐weighted images in the brain of a healthy volunteer obtained by the proposed Nexus console matches closely to a commonly applied commercial system. The use of additional receive channels was demonstrated for system monitoring (radiofrequency pulses and gradient currents), electromagnetic interference detection, and temperature and B0 field monitoring. Based on these measurements, system calibrations and electromagnetic interference–mitigation techniques were applied to improve image quality.ConclusionOur console offers high versatility in terms of data acquisition, is freely configurable, adheres to open‐source data standards, and is easy to customize. It yields a similar image quality compared with a commercially available reference system yet is substantially lower cost and open source.
Complete shielding of multivitamins to reduce toxic peroxides in the parenteral nutrition (C‐SMART‐PN): A randomized controlled pilot study
Authors: El Raichani Nadine , Thibaut Maxime , Lavoie Jean‐Claude , Mohamed Ibrahim 
Published: January 2025

AbstractBackgroundWhen exposed to ambient light, parenteral nutrition (PN) contamination with peroxides almost doubles, which increases oxidative stress in preterm infants, contributing to the development of bronchopulmonary dysplasia. The American Society for Parenteral and Enteral Nutrition (ASPEN) recommends complete PN photoprotection to reduce peroxide contamination and optimize its integrity but acknowledges the challenges of its implementation. In this study, a novel photoprotection procedure was tested for its effectiveness in reducing peroxide load and limiting ascorbic acid degradation, and for its feasibility and effectiveness in reducing urinary peroxide levels in preterm infants.MethodsIn vitro evaluation included neonatal lipid injectable emulsion–free PN admixtures prepared and infused according to current practice or the suggested photoprotection procedure through separation and complete shielding of intravenous multivitamin preparation from compounding to administration through photoprotected infusion sets. In vivo evaluation included a single‐center randomized controlled pilot study of extremely preterm infants receiving PN according to current practice or the suggested photoprotection procedure.ResultsIn vitro, photoprotection allowed a 44% decrease in peroxide generation (P < 0.001) and reduced by half ascorbic acid degradation in PN admixtures (P < 0.001). In vivo, 28 infants completed the study. Baseline urinary peroxide levels were similar in both groups before PN initiation, and the suggested photoprotection procedure resulted in a significant decrease in urinary peroxide levels over the first week of life (P < 0.05).ConclusionThe suggested procedure appears feasible and effective in reducing peroxide contamination and optimizing PN integrity, representing a step toward integrating complete photoprotection of PN as the standard of care in preterm infants.
The Experiences of Nursing Students Who Attended Hospital Clinicals During the COVID‐19 Pandemic: A Qualitative Study
Authors: Özer Güçlüel Yasemin , Kendirkiran Gülcan , Gökoğlu Gürer Pelin 
Published: January 2025

ABSTRACTAimThis study examined the experiences of nursing students who attended hospital clinicals during the COVID‐19 pandemic.DesignStudy was conducted in a descriptive design.MethodsA total of 21 nursing students from the second, third and fourth grades who attended hospital clinics in the spring semester of the 2020–2021 academic year and volunteered to participate in the study were included in the study. Purposive sampling method was used in the study. The themes obtained through content analysis of the interviews were listed and sub‐themes were created. The NVivo computer program was also used in the analysis of the study data.ResultsA total six main themes were identified in this study. These main themes are the psychological effects of COVID‐19 on students, the effects on their families, the effects on their clinical practice, the students' perspectives on the profession, the behaviours of the staff in the clinical area and the behaviours of patients/patient relatives.Patient or Public ContributionToday, different crisis situations such as pandemics can be encountered. It is important to understand and analyse the experiences of nursing students in difficult and crisis situations. It is clear that the psychological effects on nursing students are high in crisis situations. This study can form a basis for many factors such as preventing stress‐related problems in students in crisis situations, preventing them from leaving the profession and developing a positive view of the profession.