bluuebunny/crossref_metadata_2025_split huggingface dataset:
Futoquinol improves Aβ25–35‐induced memory impairment in mice by inhibiting the activation of p38MAPK through the glycolysis pathway and regulating the composition of the gut microbiota
Authors: Zhang Yuhan , Chen Hui , Zeng Mengnan , Guo Pengli , Liu Meng , Cao Bing , Wang Ru , Hao Fengxiao , Zheng Xiaoke , Feng Weisheng 
Published: February 2024

AbstractFutoquinol (Fut) is a compound extracted from Piper kadsura that has a nerve cell protection effect. However, it is unclear whether Fut has protective effects in Alzheimer's disease (AD). In this study, we aimed to explore the therapeutic effect of Fut in AD and its underlying mechanism. UPLC‐MS/MS method was performed to quantify Fut in the hippocampus of mice brain. The cognition ability, neuronal and mitochondria damage, and levels of Aβ1–42, Aβ1–40, p‐Tau, oxidative stress, apoptosis, immune cells, and inflammatory factors were measured in Aβ25–35‐induced mice. The content of bacterial meta‐geometry was predicted in the microbial composition based on 16S rDNA. The protein levels of HK II, p‐p38MAPK, and p38MAPK were detected. PC‐12 cells were cultured in vitro, and glucose was added to activate glycolysis to further explore the mechanism of action of Fut intervention in AD. Fut improved the memory and learning ability of Aβ25–35 mice, and reduced neuronal damage and the deposition of Aβ and Tau proteins. Moreover, Fut reduced mitochondrial damage, the levels of oxidative stress, apoptosis, and inflammatory factors. Fut significantly inhibited the expression of HK II and p‐p38MAPK proteins. The in vitro experiment showed that p38MAPK was activated and Fut action inhibited after adding 10 mM glucose. Fut might inhibit the activation of p38MAPK through the glycolysis pathway, thereby reducing oxidative stress, apoptosis, and inflammatory factors and improving Aβ25–35‐induced memory impairment in mice. These data provide pharmacological rationale for Fut in the treatment of AD.
Migration of catalyst elements from polyethylene terephthalate bottles into food simulants and mineral water under short‐ and long‐term conditions
Authors: Kishi Eri , Ozaki Asako , Ooshima Tomoko , Abe Yutaka , Mutsuga Motoh , Yamaguchi Yukihiko , Yamano Tetsuo 
Published: February 2024

AbstractAs polyethylene terephthalate (PET) bottles are common beverage containers, their safety is a matter of grave concern. In this study, migration behaviour of five elements (Ge, Ti, Sb, Co and P) used as catalysts, bluing agents and stabilizers during manufacturing from PET into beverages were assessed. Migration tests were performed on eight unused PET bottles under various conditions (food simulants: distilled water, 4% acetic acid and 50% ethanol; time: 10 days to 24 months; temperature: 25–60°C). The migration levels of two catalyst elements (Ge and Sb) under these conditions were 0.12–31.9 and <0.1–1.8, respectively, whereas Ti, Co and P were not detected (<2, <0.1 and <20 μg/L, respectively). The results showed storage temperature were positively correlated with migration of Sb and Ge in all food simulants. Different food simulants led to different levels of these elements migration at the same storage time and temperature, and the levels into 50% ethanol were higher than those into the other two food simulants. It was also shown that migration levels of Sb and Ge were below 2 and 20 μg/L even after 2 years of storage at room temperature, not exceeding the Japanese and EU regulation values. The Sb levels in distilled water were similar to those in commercially available bottled mineral waters, indicating that the migration tests provide a good reflection of the actual situation.
Performance and accuracy of cross‐section tracking methods for hydromorphological habitat assessment in wadable rivers with sparse canopy conditions
Authors: Schroff Robin , De Cesare Giovanni , Perona Paolo 
Published: February 2024

AbstractThis article investigates the performance and accuracy of continuous Real‐Time Kinematic (RTK) Global Navigation Satellite System (GNSS) position tracking for hydromorphological surveys, based on a comprehensive river restoration monitoring campaign. The aim of the research was to assess the method's suitability for efficient data collection in turbid, wadable rivers with sparse canopy conditions, and responds to the water management sector's increasing demand for efficient, low‐cost, and robust survey techniques. The methodological approach involved comparing manual, cross‐sectional water depth measurements to water depth estimations obtained by applying different interpolation methods to the continuous tracking data. The results demonstrate good agreement between both datasets (R2 = 0.77, RMSE = 0.13 m). When using a local standard deviation filter to remove noisy RTK‐GNSS measurements, estimation performance increased significantly (R2 = 0.96, RMSE = 0.06 m). The filter's influence on the hydromorphological habitat statistics mean water depth and coefficient of variation was limited but proved to be relevant for reach‐scale assessments of hydromorphological diversity. Based on a correlation analysis of >106 RTK‐GNSS position logs, we furthermore assessed the impact of tree canopy on RTK‐GNSS measurement accuracy and observed a strong influence within 6.5 m from the canopy border. Estimated accuracy deteriorated noticeably when canopy penetration exceeded 1 m, and accuracies >1 m were common beyond 4 m penetration. The study highlights the efficiency gains achieved with RTK‐GNSS tracking, and showcases its potential for hydromorphological surveys and streamgaging applications in challenging conditions, making it a promising alternative to traditional methods and remote sensing techniques.
Reading between the lines: The intersection of research attention and sustainable development goals
Authors: Funk Christoph , Tönjes Elena , Teuber Ramona , Breuer Lutz 
Published: February 2024

AbstractIn September 2015, the United Nations (UN) adopted 17 Sustainable Development Goals (SDGs) to transform our world by 2030. The scientific discourse around these SDGs has expanded rapidly since then, highlighting the need for efficient analysis of the large amount of textual data using Natural Language Processing. Our research addresses this need by employing a zero‐shot text classification for SDG‐related scientific articles, which allows for a thorough examination of scholarly discourse and the relationship between research attention and SDG achievement. We introduce the Research Attention Index (RAI), a novel metric that quantifies the research attention each SDG receives within a specific country. Our study contributes to the existing literature by providing a holistic view of global research attention to the SDGs. It also demonstrates the effectiveness of zero‐shot text classification for large‐scale textual labeling, and underlines the relevance of abstract analysis in understanding SDG‐related discourse. Moreover, we examine the (non)‐linear relationship between the RAI and SDG achievement across countries. Our results indicate considerable variations in the scientific discourse across countries worldwide and reveal a complex, non‐linear relationship between research attention and progress towards achieving the SDGs. This underscores the importance of understanding the dynamics between research attention and sustainable development outcomes.
Exploring the causal relationship between PM 2.5 air pollution and urban areas economic welfare and social‐wellbeing: Evidence form 15 European capitals
Authors: Andrei Jean Vasile , Cristea Dragoş Sebastian , Nuţă Florian Marcel , Petrea Ştefan‐Mihai , Nuţă Alina Cristina , Tudor Adriana Tiron , Chivu Luminita 
Published: February 2024

AbstractThis paper aims to investigate the relationship between air pollution (PM2.5) and a collection of features related to urban areas economic welfare and social‐wellbeing based on data collected from a number of 15 European capitals, for a seven years' period (2010–2017). The empirical analysis describes the correlation between the particulate pollution and welfare features in selected urban areas. Moreover, the PM2.5 pollutions may affect the economic and social development of these areas as, both entrepreneurs and population are inclined to relocate for a healthier environment. The models emphasize aspects related to the impact of PM 2.5 on different dimensions as follows: real estate rent values and land prices, restaurants food prices, community economic development, human welfare, as well as urban traffic. From the various correlations we have also discovered that for the urban areas included in the research, at early stages urbanization has the highest impact on air pollution. The findings of this study may offer hints for decision makers for their social and economic policy options. A clean urban environment will attract more skilled employees seeking for economic, social and environmental wellbeing. If the urban agglomerations authorities will fail to mitigate properly the air pollution issues the wellbeing will decrease along with the willingness of urban population to stay in such areas.
Fabrication and Characterization of Metal/Semiconductor Junction Devices Using Four Benzaldehyde Derivatives
Authors: Das Prantika , Das Mainak , Ray Partha Pratim , Seth Saikat Kumar 
Published: February 2024

AbstractFour benzaldehyde derivatives [ALD‐1: compound (1), ALD‐2: compound (2), ALD‐5: compound (3), ALD‐6: compound (4)] were taken to investigate their optical band gap by UV‐vis spectroscopy. Semiconducting devices were fabricated using these compounds to study their electrical properties. The current‐voltage (I–V) characteristics graph was obtained. Furthermore, the diode parameters were extracted by conventional methods to analyze the charge transport mechanism. From the dielectric study, a low dielectric constant was observed. Moreover, each compound‘s mobility and transit time were derived to compare the device performance of benzaldehyde derivatives.
Gelatin‐Encapsulated Tetrahedral DNA Nanostructure Enhances Cellular Internalization for Treating Noise‐Induced Hearing Loss
Authors: Xu Ke , Du Yiwei , Xu Baoying , Huang Yuqi , Feng Wei , Yu Dehong , Chen Yu , Wang Xueling 
Published: February 2024

AbstractNanoparticle‐based drug delivery strategies have emerged as a crucial avenue for comprehensive sensorineural hearing loss treatment. Nevertheless, developing therapy vectors crossing both biological and cellular barriers has encountered significant challenges deriving from various external factors. Herein, the rational integration of gelatin nanoparticles (GNPs) with tetrahedral DNA nanostructures (TDNs) to engineer a distinct drug‐delivery nanosystem (designed as TDN@GNP) efficiently enhances the biological permeability and cellular internalization, further resolving the dilemma of noise‐induced hearing loss via loading epigallocatechin gallate (EGCG) with anti‐lipid peroxidation property. Rationally engineering of TDN@GNP demonstrates dramatic alterations in the physicochemical key parameters of TDNs that are pivotal in cell‐particle interactions and promote cellular uptake through multiple endocytic pathways. Furthermore, the EGCG‐loaded nanosystem (TDN‐EGCG@GNP) facilitates efficient inner ear drug delivery by superior permeability through the biological barrier (round window membrane), maintaining high drug concentration within the inner ear. The TDN‐EGCG@GNP actively overcomes the cell membrane, exhibiting hearing protection from noise insults via reduced lipid peroxidation in outer hair cells and spiral ganglion neurons. This work exemplifies how integrating diverse vector functionalities can overcome biological and cellular barriers in the inner ear, offering promising applications for inner ear disorders.
Semiconducting 2D Copper(I) Iodide Coordination Polymer as a Potential Chemiresistive Sensor for Methanol
Authors: Mishra Shivendu , Patel Chandrabhan , Pandey Dilip , Mukherjee Shaibal , Raghuvanshi Abhinav 
Published: February 2024

AbstractThe development of a cost‐effective, ultra‐selective, and room temperature gas sensor is the need of an hour, owing to the rapid industrialization. Here, a new 2D semiconducting Cu(I) coordination polymer (CP) with 1,4‐di(1H‐1,2,4‐triazol‐1‐yl)benzene (1,4‐TzB) ligand is reported. The CP1 consists of a Cu2I2 secondary building unit bridged by 1,4‐TzB, and has high stability as well as semiconducting properties. The chemiresistive sensor, developed by a facile drop‐casting method derived from CP1, demonstrates a response value of 66.7 at 100 ppm on methanol exposure, accompanied by swift transient (response and recovery time 17.5 and 34.2 s, respectively) behavior. In addition, the developed sensor displays ultra‐high selectivity toward methanol over other volatile organic compounds , boasting LOD and LOQ values of 1.22 and 4.02 ppb, respectively. The CP is found to be a state‐of‐the‐art chemiresistive sensor with ultra‐high sensitivity and selectivity toward methanol at room temperature.
In Situ Modulation of Oxygen Vacancies on 2D Metal Hydroxide Organic Frameworks for High‐Efficiency Oxygen Evolution Reaction
Authors: Ge Kai , Zhao Yi , Hu Yidong , Wang Zhuozhi , Wang Jingjing , Yang Mingtao , Cui He , Yang Yongfang , Zhu Lei , Shen Boxiong 
Published: February 2024

AbstractThe discovery of non‐precious catalysts for replacing the precious metal of ruthenium in the oxygen evolution reaction (OER) represents a key step in reducing the cost of green hydrogen production. The 2D d‐MHOFs, a new 2D materials with controllable oxygen vacancies formed by controlling the degree of coordination bridging between metal hydroxyl oxide and BDC ligands are synthesized at room temperature, exhibit excellent OER properties with low overpotentials of 207  mV at 10 mA cm−2. High‐resolution transmission electron microscopy images and density functional theory calculations demonstrate that the introduction of oxygen vacancy sites leads to a lattice distortion and charge redistribution in the catalysts, enhancing the OER activity of 2D d‐MHOFs comprehensively. Synchrotron radiation and in situ Raman/Fourier transform infrared spectroscopy indicate that part of oxygen defect sites on the surface of 2D d‐MHOFs are prone to transition to highly active metal hydroxyl oxides during the OER process. This work provides a mild strategy for scalable preparation of 2D d‐MHOFs nanosheets with controllable oxygen defects, reveals the relationship between oxygen vacancies and OER performance, and offers a profound insight into the basic process of structural transformation in the OER process.
Brandrisiko von E‐Fahrzeugen und kraftstoffbetriebenen Fahrzeugen in offenen, oberirdischen Parkgaragen: Teil 2: Bauteilbemessung und Zuverlässigkeitsanalyse
Authors: Meyer Patrick , Schaumann Peter , Sander Lisa , Zehfuß Jochen 
Published: February 2024

AbstractUm dem Klimawandel zu begegnen, ist u. a. ein Umstieg von Fahrzeugen mit Verbrennungsmotoren auf E‐Fahrzeuge geboten. Konsequenterweise ist in Deutschland eine stark zunehmende Anzahl von E‐Fahrzeugen zu beobachten. In diesem Zusammenhang stellt sich die Frage, ob und – wenn ja – wie sich diese Entwicklung auf Brandrisiken in Parkgaragen auswirkt. Antworten auf diese Frage gibt ein Forschungsprojekt unter Federführung des Instituts für Stahlbau der Leibniz Universität Hannover in Kooperation mit dem iBMB, Fachgebiet Brandschutz, der TU Braunschweig. Konkret ging es darum, wie sich die unterschiedlichen Brandszenarien von E‐Fahrzeugen im Vergleich zu Fahrzeugen mit Verbrennungsmotoren auf das Tragverhalten von Stahl‐ und Stahlverbundkonstruktionen in offenen, oberirdischen Parkhäusern auswirken. In diesem Beitrag wird die methodische Vorgehensweise zur Bewertung des Brandrisikos auf Basis einer Zuverlässigkeitsanalyse für die Tragstrukturen dieser Parkgaragen erläutert. Mittels der Zuverlässigkeitsanalyse wird an exemplarischen Brandszenarien für einen Verbundträger die Vorgehensweise zur Bewertung des Brandrisikos dargestellt. Im Ergebnis kann aus der Brandrisikoanalyse abgeleitet werden, dass Brandszenarien mit E‐Fahrzeugen keine höheren Risiken als herkömmliche Fahrzeuge mit Verbrennungsmotoren bergen und das gebotene Sicherheitsniveau erfüllen.
Strukturspannungen an Kreishohlprofilknoten – Methoden im Vergleich
Authors: Krahl Philipp , Kühn Bertram , Stranghöner Natalie 
Published: February 2024

AbstractZur Bewertung der Ermüdungsfestigkeit von Hohlprofilknoten wird bevorzugt das Strukturspannungskonzept herangezogen. Die Bestimmung der entsprechenden Beanspruchungskennwerte kann grundsätzlich anhand verschiedener Methoden erfolgen. Diesbezüglich wird überwiegend die Methode der Oberflächenextrapolation angewandt, welche in normativen Regelwerken fest verankert ist. Im Rahmen des Beitrags wird neben diesem etablierten Verfahren das Konzept der Innenlinearisierung näher erläutert, da hierzu in einschlägigen Regelwerken nur weniger detaillierte Anwendungshinweise formuliert sind. Darüber hinaus wird ein alternativer Ansatz vorgestellt, der es prinzipiell ermöglicht, Strukturspannungen direkt dem Berechnungsmodell zu entnehmen. Um eine aussagekräftige Bewertung der Vergleichbarkeit und Allgemeingültigkeit der Verfahren vornehmen zu können, wurden Untersuchungen an K‐, Y‐ sowie KK‐Knoten durchgeführt. Die Ergebnisse werden abschließend gegenübergestellt.
Zur Bemessung von Verbunddübelleisten mit Klothoidenform für Schubbeanspruchungen in Längs‐ und Querrichtung
Authors: Wisnewski Joachim , Lewerenz Camilla , Stroetmann Richard 
Published: February 2024

AbstractBei Straßenbrücken mit orthotrop ausgesteiften Stahlfahrbahnplatten sind in den vergangenen Jahrzehnten aufgrund der stark angestiegenen Verkehrsbelastung und einer unzureichenden Auslegung vermehrt Ermüdungsschäden aufgetreten. Um die Vorteile der leichten Bauweise zu nutzen, aber gleichzeitig wesentliche Probleme zu beseitigen, wurde an der Technischen Universität Dresden im Rahmen des AiF‐FOSTA‐Forschungsprojekts P 1265 die Orthoverbundfahrbahnplatte mit Dübelleisten entwickelt. Anders als in der Bauartgenehmigung berücksichtigt, wird die Verbunddübelleiste in der Orthoverbundfahrbahnplatte in Längs‐ und Querrichtung auf Schub beansprucht. Der Verbund zwischen der Stahlkonstruktion und der dünnen Aufbetonschicht wird bei dieser Bauweise in beiden Richtungen hergestellt und statisch genutzt. Bisher wurden bei Verbunddübelleisten weder die Tragfähigkeit noch die Tragwirkung bei Querschubbeanspruchung untersucht. Aufgrund der bewusst gering gewählten Stärke der Stahlbetonschicht waren Abweichungen der Leistengeometrie von der geltenden Bauartgenehmigung notwendig. Im Forschungsprojekt P 1265 wurden daher umfangreiche experimentelle und strukturmechanische Untersuchungen des Tragverhaltens von Verbunddübelleisten in Klothoidenform in Längs‐ und Querrichtung durchgeführt und Bemessungsansätze hieraus abgeleitet bzw. überprüft. Im vorliegenden Aufsatz wird eine Zusammenfassung hierzu vorgestellt.
ELF Communication Strategies: A Pedagogical Intervention Pilot Study
Authors: Caprario Marcella 
Published: February 2024

AbstractThis study investigated the feasibility and effectiveness of ELF communication strategy instruction for university students’ communicative competence. Conceptual studies on ELF‐informed pedagogy stress the importance of teaching strategies, which promote mutual understanding and positive relationships, but few empirical pedagogical studies exist. This gap seriously hinders efforts to develop more inclusive English language and intercultural communication teaching practices that meet real‐world communication needs. In response, this pilot study developed and tested the effectiveness of instructional materials and assessment instruments for teaching ELF communication strategies. These materials were pilot tested with 26 L1 and LX English speaking participants. The two assessments resulted in statistically significant improvements from pre‐ to posttest with small effect sizes. Participant opinion survey responses were overwhelmingly positive. Based on these encouraging preliminary results, follow‐up pedagogical studies should expand on this pilot study to yield a more comprehensive understanding of ELF communication strategy instruction.
Effect of blending sequence and epoxy functionalized compatibilizer on barrier and mechanical properties of PBS and PBS/PLA nanocomposite blown films
Authors: Adrar Salima , Ajji Abdellah 
Published: February 2024

AbstractThis study focuses on developing compostable nanocomposite blown films, aiming to enhance oxygen barrier properties while maintaining good mechanical performance. Polybutylene succinate (PBS) and its blend with polylactic acid (PLA) were selected as matrices for the films. Organo‐montmorillonite Delite®43B (D43B) clay was incorporated to improve oxygen barrier, and random ethylene‐methyl acrylate‐glycidyl methacrylate terpolymer served as a plasticizer and reactive compatibilizer. Different blending sequences were examined to determine the optimal one that led to significant enhancements in both the barrier and mechanical properties of the final nanocomposite blown film. Various techniques, including SEM, TEM, XRD, DSC, oxygen permeability, and tensile testing were employed to characterize the morphology of the compounds and blown films. The results reveal greater oxygen barrier properties depending on the blending sequence. Indeed, a reduction in oxygen permeability exceeding 50% was observed following the addition of 3 wt% of D43B to the PBS/PLA film, selectively localized in the PLA phase. This enhancement further intensified after the addition of 5 wt% of the epoxy functionalized compatibilizer.Highlights
Enhancing PLA‐PBS compatibility with the epoxy functionalized compatibilizer led to a reduction in the final film's oxygen permeability.
Achieving ideal ductility and barrier balance in films requires a synergistic blend of components: D43B, PLA, PBS, and compatibilizer.
Optimizing balanced synergistic effects among compounds depends on the blending sequence method.
Authentic leadership: Centering context to critically examine authenticity
Authors: Turman Natasha T. 
Published: February 2024

AbstractConversations on authentic leadership development all too often are devoid of contextual considerations. Little attention is placed on how authentic leadership is actualized by individuals who hold marginalized and minoritized social identities and/or whose lived experiences diverge from the privileged majority; and therefore, must strategically negotiate facets of self to “do leadership.” This article illustrates how facets of one's lived experiences, social identities, and worldviews significantly shape and guide how “authentic” leaders show up and practice leadership authentically. This article highlights how elements like code‐switching and impression management challenge preconceived notions of what it means to be “good” and “genuine” as a leader to better understand how a theory like authentic leadership gets operationalized. This deeper analysis of authentic leadership provides a nuanced perspective to inform curricular and co‐curricular designs that are mindful of context, power, and privilege as well as the uniqueness of the individual.
Emerging from critique towards liberation: A Framework in leadership education
Authors: Wiborg Erica R. , Manning‐Ouellette Amber , Roland Ericka 
Published: February 2024

AbstractWhat does liberation look like in leadership learning and education? This article offers examples for (re)imagining leadership education in program design, coordination, and assessment by centering the leadership for liberation framework and other liberatory approaches. The authors offer examples of how these frameworks serve as an entry point for college student liberatory leadership learning.