bluuebunny/crossref_metadata_2025_split huggingface dataset:
Analysis of the concurrent validity and reliability of five common clinical goniometric devices
Authors: Kiatkulanusorn Sirirat , Luangpon Nongnuch , Srijunto Wirasinee , Watechagit Sarawoot , Pitchayadejanant Krittipat , Kuharat Sireetorn , Bég O. Anwar , Suato Bhornluck Paepetch 
Published: November 2023

AbstractMeasurement errors play an important role in the development of goniometric equipment, devices used to measure range of motion. Reasonable validity and reliability are critical for both the device and examiner before and after to testing in human subjects. The objective is to evaluate the concurrent validity and reliability of five different clinical goniometric devices for the purpose of establishing an acceptable measurement error margin for a novel device. We explored the validity and inter- and intrarater reliability scores of five goniometric devices namely (i) the universal goniometer (UG), a two-armed hand-held goniometer, (ii) the inclinometer (IC), featuring a single base, fluid level, and gravity-weighted inclinometer, (iii) the digital inclinometer (DI), functioning as both a DI and dynamometer, (iv) the smartphone application (SA), employing gyroscope-based technology within a smartphone platform application and (v) the modified inclinometer (MI), a gravity pendulum-based inclinometer equipped with a specialized fixing apparatus. Measurements were obtained at 12 standard angles and 8 human shoulder flexion angles ranging from 0° to 180°. Over two testing sessions, 120 standardized angle measurements and 160 shoulder angle measurements from 20 shoulders were repetitively taken by three examiners for each device. The intraclass correlation coefficient (ICC), standard error of measurement (SEM), and minimal detectable change (MDC) were calculated to assess reliability and validity. Concurrent validity was also evaluated through the execution of the 95% limit of agreement (95% LOA) and Bland–Altman plots, with comparisons made to the UG. The concurrent validity for all device pairs was excellent in both study phases (ICC > 0.99, 95% LOA − 4.11° to 4.04° for standard angles, and − 10.98° to 11.36° for human joint angles). Inter- and intrarater reliability scores for standard angles were excellent across all devices (ICC > 0.98, SEM 0.59°–1.75°, MDC 1°–4°), with DI showing superior reliability. For human joint angles, device reliability ranged from moderate to excellent (ICC 0.697–0.975, SEM 1.93°–4.64°, MDC 5°–11° for inter-rater reliability; ICC 0.660–0.996, SEM 0.77°–4.06°, MDC 2°–9° for intra-rater reliability), with SA demonstrating superior reliability. Wider angle measurement however resulted in reduced device reliability. In conclusion, our study demonstrates that it is essential to assess measurement errors independently for standard and human joint angles. The DI is the preferred reference for standard angle testing, while the SA is recommended for human joint angle testing. Separate evaluations across the complete 0°–180° range offer valuable insights.
All-trans retinoic acid and dexamethasone regulate phagocytosis-related gene expression and enhance dead cell uptake in C2C12 myoblast cells
Authors: Adil Ali Maysaa , Garabuczi Éva , Tarban Nastaran , Sarang Zsolt 
Published: November 2023

AbstractExtensive mechanical stress frequently causes micro-traumas in skeletal muscle, followed by a regeneration period. The effective removal of dead myofibers is a prerequisite for proper regeneration, and several cell types, including professional phagocytes, were reported to be active in this process. Myoblasts express several molecules of the phagocytic machinery, such as BAI1, stabilin-2, and TAM (Tyro3, Axl, Mertk) tyrosine kinase receptors, but these molecules were reported to serve primarily cell fusion and survival, and their role in the phagocytosis was not investigated. Therefore, we aimed to investigate the in vitro phagocytic capacity of the C2C12 mouse myoblast cell line. RNA sequencing data were analyzed to determine the level and changes of phagocytosis-related gene expression during the differentiation process of C2C12 cells. To study the phagocytic capacity of myoblasts and the effect of dexamethasone, all-trans retinoic acid, hemin, and TAM kinase inhibitor treatments on phagocytosis, C2C12 cells were fed dead thymocytes, and their phagocytic capacity was determined by flow cytometry. The effect of dexamethasone and all-trans retinoic acid on phagocytosis-related gene expression was determined by quantitative PCR. Both undifferentiated and differentiated cells engulfed dead cells being the undifferentiated cells more effective. In line with this, we observed that the expression of several phagocytosis-related genes was downregulated during the differentiation process. The phagocytosis could be increased by dexamethasone and all-trans retinoic acid and decreased by hemin and TAM kinase inhibitor treatments. Our results indicate that myoblasts not only express phagocytic machinery genes but are capable of efficient dead cell clearance as well, and this is regulated similarly, as reported in professional phagocytes.
Functional brain region-specific neural spheroids for modeling neurological diseases and therapeutics screening
Authors: Strong Caroline E. , Zhang Jiajing , Carrasco Martin , Kundu Srikanya , Boutin Molly , Vishwasrao Harshad D. , Liu Jiamin , Medina Angelica , Chen Yu-Chi , Wilson Kelli , Lee Emily M. , Ferrer Marc 
Published: November 2023

Abstract3D spheroids have emerged as powerful drug discovery tools given their high-throughput screening (HTS) compatibility. Here, we describe a method for generating functional neural spheroids by cell-aggregation of differentiated human induced pluripotent stem cell (hiPSC)-derived neurons and astrocytes at cell type compositions mimicking specific regions of the human brain. Recordings of intracellular calcium oscillations were used as functional assays, and the utility of this spheroids system was shown through disease modeling, drug testing, and formation of assembloids to model neurocircuitry. As a proof of concept, we generated spheroids incorporating neurons with Alzheimer’s disease-associated alleles, as well as opioid use disorder modeling spheroids induced by chronic treatment of a mu-opioid receptor agonist. We reversed baseline functional deficits in each pilot disease model with clinically approved treatments and showed that assembloid activity can be chemogenetically manipulated. Here, we lay the groundwork for brain region-specific neural spheroids as a robust functional assay platform for HTS studies.
Alteration in cartilage matrix stiffness as an indicator and modulator of osteoarthritis
Authors: Song Jing , Zeng Xuemin , Li Chenzhi , Yin Hongyan , Mao Sui , Ren Dapeng 
Published: November 2023

Abstract
Osteoarthritis (OA) is characterized by cartilage degeneration and destruction, leading to joint ankylosis and disability. The major challenge in diagnosing OA at early stage is not only lack of clinical symptoms but also the insufficient histological and immunohistochemical signs. Alteration in cartilage stiffness during OA progression, especially at OA initiation, has been confirmed by growing evidences. Moreover, the stiffness of cartilage extracellular matrix (ECM), pericellular matrix (PCM) and chondrocytes during OA development are dynamically changed in unique and distinct fashions, revealing possibly inconsistent conclusions when detecting cartilage matrix stiffness at different locations and scales. In addition, it will be discussed regarding the mechanisms through which OA-related cartilage degenerations exhibit stiffened or softened matrix, highlighting some critical events that generally incurred to cartilage stiffness alteration, as well as some typical molecules that participated in constituting the mechanical properties of cartilage. Finally, in vitro culturing chondrocytes in various stiffness-tunable scaffolds provided a reliable method to explore the matrix stiffness-dependent modulation of chondrocyte metabolism, which offers valuable information on optimizing implant scaffolds to maximally promote cartilage repair and regeneration during OA. Overall, this review systematically and comprehensively elucidated the current progresses in the relationship between cartilage stiffness alteration and OA progression. We hope that deeper attention and understanding in this researching field will not only develop more innovative methods in OA early detection and diagnose but also provide promising ideas in OA therapy and prognosis.
Modeling energetic proton transport in a corotating interaction region
Authors: Tao Xinyi , Shen Fang , Wei Wenwen , Zhu Yuji , Luo Xi , Feng XueShang 
Published: November 2023

Aims. An energetic particle event related to a corotating interaction region (CIR) structure was observed by the Solar-Terrestrial Relations Observatory-A (STEREO-A) from 21 to 24 August 2016. Based on an analysis of measurement data, we suggest that instead of being accelerated by distant shocks, a local mechanism similar to diffusive shock acceleration (DSA) acting in the compression region could explain the flux enhancements of 1.8–10.0 MeV nucleon−1 protons. We created simulations to verify our hypothesis.
Methods. We developed a coupled model composed of a data-driven analytical background model providing solar wind configuration and a particle transport model represented by the focused transport equation (FTE). We simulated particle transport in the CIR region of interest in order to obtain the evolution of proton fluxes and derive the spectra.
Results. We find that the simulation is well correlated with the observation. The mechanism of particle scattering back and forth between the trap-like structure of interplanetary magnetic field (IMF) in the compression region is the major factor responsible for the flux enhancements in this energetic particle event, and perpendicular diffusion identified by a ratio of κ⊥/κ|| ∼ 10−2 plays an important role in the temporal evolution of proton fluxes.
Observational signature of continuously operating drivers of decayless kink oscillation
Authors: Li Dong , Li Zhentong , Shi Fanpeng , Su Yang , Chen Wei , Yu Fu , Li Chuan , Qiu Ye , Huang Yu , Ning Zongjun 
Published: November 2023

Context. Decayless kink oscillations, which are nearly omnipresent in the solar corona, are believed to be driven by continuously operating energy supply.
Aims. In this Letter, we investigate an external continuous excitation of an apparent decayless oscillation during an X1.1 flare on June 20, 2023 (SOL2023-06-20T16:42).
Methods. The decayless kink oscillation was identified in the coronal loop at extreme ultraviolet (EUV) wavelengths and the associated flare quasi-periodic pulsations (QPPs) were simultaneously observed in passbands of hard X-ray (HXR), microwave, and ultraviolet (UV) emissions.
Results. The kink oscillation is detected as a transverse oscillation of the coronal loop, which reveals five apparent cycles with an average period of about 130 ± 10 s. The oscillation amplitude does not show any significantly decay, suggesting a decayless oscillation. At the same time, the solar flare occurs in the vicinity of the oscillating loop and exhibits five main pulses in HXR, microwave, and UV emissions, which could be regarded as flare QPPs. They have similar periods of about 100–130 s, which may indicate successive and repetitive energy releases during the flare impulsive phase. The peak of each loop oscillation cycle appears to follow the pulse of the QPPs, suggesting that the transverse oscillation is closely associated with flare QPPs.
Conclusions. Our observations support the scenario where the repetitive energy released following flare QPPs could be invoked as external, continuously operating drivers of the apparent decayless kink oscillation.
Quantifying the non-Gaussian gain
Authors: Allen David , Satchell Stephen , Lizieri Colin 
Published: November 2023

AbstractIn this paper, we quantify the economic gain from accounting for departures from normality for the mean-variance (MV) investor. We provide two models that account for the key empirical regularities of financial returns: stochastic volatility, asymmetric returns, heavy tails and tail dependence. We show that accounting for departures from normality leads to significant gains in expected utility commensurate with or exceeding typical active management fees. The majority of the uplift in expected utility derives from accounting for stochastic volatility.
Prioritising research funding for cardiovascular disease and diabetes in Australia
Authors: Grundy Emily A. C. , Kelly Lauren E. , Kneipp Erica , Clynes Lucy , Saeri Alexander K. , Bragge Peter 
Published: November 2023

AbstractThe Targeted Translation Research Accelerator program was created to address cardiovascular disease and diabetes in Australia. To maximise the impact of the considerable investment in this program, a structured prioritisation project was undertaken to determine the highest priority health and medical unmet needs in cardiovascular disease and diabetes. The project was led by Monash University’s Behaviour Works Australia in collaboration with Australian National University, Research Australia, and MTPConnect. We conducted an online survey with 318 experts and community representatives to generate a ‘long list’ of unmet needs for (1) cardiovascular disease; (2) diabetes; and (3) interactions in the pathogenesis of Type 1 diabetes, Type 2 diabetes, and cardiovascular disease. We then convened roundtables of clinical, research, and community leaders to discuss survey results. They prioritised unmet needs against six predefined criteria then discussed results. We present the final priority areas for funding. We demonstrate how a feasible, reproducible, and collaborative prioritisation methodology can be used when designing research funding programs. Such approaches can ensure that funding is directed towards projects that are valuable to the community and reflective of expert opinion.
Design optimization of electromagnetic shielding and charging efficiency for electric vehicle wireless charging system
Authors: Dai Wenpan , Geng Ziyan , Ouyang Bo , Shen Yang 
Published: November 2023

Electric vehicle (EV) technology is rapidly advancing, yet the wireless charging system for EVs still faces challenges in terms of insufficient charging efficiency and electromagnetic safety. To overcome these obstacles, this study proposes a novel approach by integrating the double-ended charge-level capacitance charging model with a composite electromagnetic shielding scheme, resulting in the charge-level capacitance composite shielding charging model. Experimental verification confirms the effectiveness of the proposed composite electromagnetic shielding model, demonstrating superior shielding performance compared to conventional models. Furthermore, performance analysis of the suggested charge-level capacitance composite shielding charging model reveals a disk loss of 0.087 W, a transmission efficiency of 98.25%, and a magnetic induction strength of 9.09 T. Collectively, these comprehensive findings indicate that the proposed charging model offers enhanced charging performance and electromagnetic shielding capabilities, surpassing those of traditional models, and holds practical value for real-world implementation.
Systematic review of longitudinal studies on the association between cluster of health-related behaviors and tooth loss among adults
Authors: Alobaidi Fatimah , Heidari Ellie , Sabbah Wael 
Published: November 2023

Objectives: To systematically review longitudinal studies on the association between cluster of/multiple health-related behaviors and tooth loss among adults.
Materials and methods: Inclusion criteria were prospective and retrospective longitudinal studies; adults; multiple or cluster of behaviors; tooth loss, one or more tooth lost and complete tooth loss. Exclusion criteria were intervention studies; cross-sectional studies; case-control studies; children under 18 years-old; single behavior. Two reviewers searched three databases up to April 2023. Open Grey and Google Scholar were searched for grey literature.
Results: Twelve longitudinal studies were included in this review. Nine studies had good quality, two had poor quality, and one had fair quality according to New-Castle-Ottawa Scale. According to ROBINS-E tool, nine studies were judged as moderate risk of bias while two studies were at low risk of bias and one study had serious risk of bias. One study assessed cluster of behavior, while others examined a number of separate health-related behaviors in relation to tooth loss. Meta-analysis was not feasible because of the high heterogeneity in exposure, measure of outcomes, covariates, sample size, and follow-up time. The research found an association between tooth loss and oral hygiene practices (two studies), dental attendance (four studies), smoking (six studies), and alcohol consumption (three studies).
Conclusion: This review provides evidence of a longitudinal association between cluster of/multiple health related-behaviors and tooth loss.
Skyrmion motion under temperature gradient and application in logic devices
Authors: Raj Ravish Kumar , Bindal Namita , Kaushik Brajesh Kumar 
Published: November 2023

Abstract
Under the presence of temperature gradient (TG) on a nanotrack, it is necessary to investigate the skyrmion dynamics in various magnetic systems under the combined effect of forces due to magnonic spin transfer torque

(
μ
S
T
T
)
,

thermal STT (

τ
S
T
T

), entropic difference

(
dS
)
,

as well as thermal induced dipolar field (DF). Hence, in this work, the dynamics of skyrmions in ferromagnets (FM), synthetic antiferromagnets (SAF), and antiferromagnets (AFM) have been studied under different TGs and damping constants (

α

G

). It is observed that

α

G

plays a major role in deciding the direction of skyrmion motion either towards the hotter or colder side in different magnetic structures. Later, FM skyrmion based logic device is proposed that consists of a cross-coupled nanotrack, where the skyrmions on horizontal and vertical nanotrack are controlled by exploiting TG and electrical STT (eSTT), respectively by taking the advantages of thermal induced skyrmion Hall effect (SkHE). The proposed device performs AND and OR logic functionalities simultaneously, when the applied current density is

2
×

10
11

A

m

-
2

.

Moreover, the proposed device is also able to exhibit the half adder functionality by tuning the applied current density to

3
×

10
11

A

m

-
2

.

The total energy consumption for AND and OR logic operation and half adder are 33.63 fJ and 25.06 fJ, respectively. This paves the way for the development of energy-efficient logic devices with ultra-high storage density.
Flat foliation of the Schwarzschild-anti-de Sitter metric
Authors: Haidar Farrukh , Siddiqui Azad A 
Published: November 2023

Abstract
Hypersurfaces used to specify a foliation are required to satisfy some geometric property. This restriction provides a way to derive a differential equation satisfied by those hypersurfaces. In this paper, a complete foliation of the Schwarzschild-anti-de Sitter spacetime by flat spacelike hypersurfaces is provided. A simple procedure based on the fact that geodesics are orthogonal to such hypersurfaces is adopted. There is a barrier found for the hypersurfaces to reach r = ∞ . The Schwarzschild-anti-de Sitter geometry is completely foliated by the analytic continuation of the hypersurfaces beyond the barrier.
Dynamics of 7Li breakup and its influence on elastic scattering: a study of 7Li + 144Sm system*
Authors: Morzabayev A. , Amangeldi N. , Ibraheem Awad A. , Soldatkhan D. , Yergaliuly G. , Mauyey B. , Orazalievna Anuar. A. , Hamada Sh. 
Published: November 2023

Abstract
The angular distributions of 7Li + 144Sm elastic scattering over the energy range of 21.6–52 MeV are reanalyzed utilizing various interaction potentials. The analysis aims to study the consistency of the implemented potentials in representing the considered data and investigate the cluster nature of the weakly bound 7Li projectile. This will aid in the better understanding the impacts of 7Li breakup on the elastic scattering channel. Strong coupling to the breakup channel has a substantial impact on the elastic data and reproduces a repulsive dynamical polarization potential, which drastically diminishes the real potential strength. This reported impact was simulated by introducing a semi-microscopic repulsive DPP and by implementing the method of continuum discretized coupled channels. The analysis was also extended to understand the impact of triton transfer on the elastic scattering data.
Analysis of Optical Character Recognition using EasyOCR under Image Degradation
Authors: Salehudin M.A.M. , Basah S.N. , Yazid H. , Basaruddin K.S. , Safar M.J.A. , Som M.H. Mat , Sidek K.A. 
Published: November 2023

Abstract
This project explores EasyOCR’s performance with Latin characters under image degradation. Variables like character-background intensity difference, Gaussian blur, and relative character size were tested. EasyOCR excels in distinguishing unique lowercase and uppercase characters but tends to favor uppercase for similar shapes like C, S, U, or Z. Results showed that high character-background intensity differences affected OCR output, with confidence scores ranging from 3 % to 80%. Higher differences caused confusion between characters like o and 0, or i and 1. Increased Gaussian blur hindered recognition but improved it for certain letters like v. Image size had a significant impact, with character detection failing as sizes decreased to 40% to 30% of the original. These findings provide insights into EasyOCR’s capabilities and limitations with Latin characters under image degradation.
Reinforcement Learning for Mobile Robot’s Environment Exploration
Authors: Teoh Sean W H , Kamarudin Kamarulzaman , Ali Nasr A N , Zainal Muhammad M M , Manan Mohd R , Mamduh Syed M 
Published: November 2023

Abstract
Mobile robots are being are being applied in various industries to perform repetitive or dangerous tasks for humans to carry out. Autonomous mobile robots are more capable than automated guided vehicles (AGV) due to their ability to be adaptable to their environment which is important for exploration of unknown environments. It is difficult to program autonomous mobile robots to adapt to various situations it may face, thus machine learning can be applied to allow a mobile robot to learn how to navigate through environments by itself. Reinforcement learning is applied in this project so that a differential drive mobile robot can learn how to navigate through its environment while avoiding collision with surrounding walls and obstacles. The reinforcement learning process is simulated by using the Robot Operating System (ROS) and its simulator Gazebo. Controlled simulation environments are created using Gazebo for the purposes of training and performance testing. Simultaneous Localization and Mapping (SLAM) will be applied to generate a map of the environment. At the end of this project, the Turtlebot3 is able to map smaller controlled environments ranging between 18m2 to 27m2 without colliding with the surrounding walls.