bluuebunny/crossref_metadata_2025_split huggingface dataset:
Biological properties of foot-and-mouth disease virus А 2205/G-IV strain
Authors: Sidorovskaya M. V. , Fomina S. N. , Nikiforov V. V. , Komarova T. A. , Shevchenko M. A. , Kolchanov N. A. , Kremenchugskaya S. R. 
Published: December 2023

According to the World Organisation for Animal Health, foot-and-mouth disease (FMD) is regularly reported in domestic and wild cloven-hoofed animals in Africa. G-I, G-IV, G-VI, G-VII, ASIA/Iran-05 genetic lineages of serotype А FMD virus are considered to be the most widespread on the African continent. Given the close economic and trade relations maintained by the Russian Federation with the countries of North Africa, of particular interest for us is studying the FMD virus of serotype A G-IV genetic lineage, which has been responsible for the infection outbreaks in the naturally susceptible animal population of the said region every year since 2012, and there is a risk of introduction of this virus genotype in to the Russian Federation. Therefore, the issues of FMD introduction risk assessment and timely diagnosis are relevant for the Veterinary Service of Russia. FMD virus A 2205/G-IV strain tested for its biological and antigenic properties in cell cultures and naturally susceptible animals (cattle and pigs) was adapted for its reproduction in initially trypsinized porcine kidney (PK) cell culture, continuous monolayer cell cultures (IB-RS-2, PSGK-30, YaDK-04, ВНК-21) by five serial passages. The virus was considered to be adapted when 90–95% cytopathic effect developed within 14–19 hours after the cell culture infection. The virus adapted to the cell cultures was tested for its infectivity with microtitration in IB-RS-2 cell culture. The virus strain tested for vaccine matching with microneutralization test (MNT) demonstrated significant difference from production A/Turkey/06, А22 No. 550/Azerbaijan/64, A22/Iraq/64, A/Iran/97, A No. 2155/Zabaikalsky/2013, A No. 2166/Krasnodarsky/2013, A No. 2269/ARRIAH/2015 strains of FMD virus.
OSMANLI TAŞRASINDA YEREL BİR GÜÇ: KÜÇÜK ALİ (1698-1743)
Authors: EKİNCİ Abdullah , TORKAK Berna 
Published: December 2023

Bu çalışma XVII. yüzyıl sonu ile XVIII. yüzyıl başlarında Diyarbekir’e bağlı Çemişgezek, Sağman, Pertek ve Mazgird sancağı malikâne mutasarrıfı Küçük Ali’nin yerel bir güç olarak yönetim anlayışını ve tasarruf pratiklerini incelenmektedir. Osmanlı taşrasında bir memurun, güç odaklarına ve halka boyun eğdirmesinde kilit rol oynayan nüanslardan biri zulümdü. Yerelde zulüm yoluyla gücünü arttırmaya çalışan Küçük Ali, kendisine finansal bir alt yapı oluştururken güçlü aktörler ile iletişim halinde olmayı ihmal etmemişti. Bu aktörlerden biri eşkıyaydı. Eşkıyayı bertaraf etme noktasında yetersiz kalan yönetim, Küçük Ali’den yardım istemişti. Bu yardım ile iktidarın taşradaki paydaşları açık şekilde ortaya çıkmıştı.
Yönetimin, paydaşlar karşısında iktidardan yardım istemesi gayri nizami hareketleri daha da arttırmıştı. Tüm bu zulüm ve keyfi davranışlar halkı bezdirme noktasına getirmişti. Halk bu noktada kaygılarını ifade edebileceği bir alanı yani mahkemeyi tercih etmişti. Taşradan merkeze uzanan hak arayış çabasında halkın şikâyetlerinin temel gayesi, adaletsizliği adalet ile terbiye etmekti.
Osmanlı taşrasında yerel güç aktörü Küçük Ali’nin adaletsizliği karşısında adaletten adalet talep eden ve haksızlığın hakkına odaklanan bu çalışma ağırlıklı olarak Mühimme Defterleri, Diyarbekir Ahkâm Defterleri, Atik Şikâyet Defterleri ve muhtelif bireysel belgelerden oluşmaktadır. Bunun yanı sıra yazılı telif eserlerden istifade edilmiştir.
Results and prospects of rotavirus immunisation in the Russian Federation
Authors: Korovkin A. S. , Ignatyev G. M. 
Published: December 2023

Scientific relevance. Rotavirus disease and its consequences remain a leading vaccine-preventable cause of mortality in young children. Russia has not yet included rotavirus immunisation in the national vaccination schedule, but paediatric rotavirus vaccines are provided under several regional immunisation programmes.Aim. The authors aimed to review literature covering Russian clinical evidence of the safety and effectiveness of rotavirus vaccines and to analyse the prospects for the development of the national immunisation programme for young children using the available rotavirus vaccines and considering promising pipeline ones.Discussion. Local epidemiological studies on a range of pathogens suggest that rotaviruses are the most common cause of acute intestinal infections, especially in children under 3 years of age. Since Russia’s first rotavirus vaccine approval in 2012, the healthcare system has acquired sufficient experience with rotavirus vaccines to evaluate the safety and effectiveness of rotavirus immunisation. Long-term monitoring of the rotavirus A genotypes circulating in the country shows that currently available rotavirus vaccines cover the majority of identified rotavirus isolates. Local observational studies confirm the favourable safety profile of rotavirus vaccines and demonstrate notable effectiveness of vaccination. In the regions with high immunisation coverage, the overall morbidity has declined dramatically in vaccinated children compared to unvaccinated children; some of these regions have reported only individual hospital visits or admissions for acute intestinal infections.Conclusion. This review demonstrates that rotavirus immunisation should be included in the Russian National Immunisation Schedule.
Prevalence of vector-borne diseases among reindeer (<i>Rangifer tarandus</i>) Bolshezemelskaya and Malozemelskaya tundr
Authors: Nikolaev S. V. , Romanenko T. M. , Bessolitsyna E. A. 
Published: December 2023

The purpose of the research is to establish the prevalence of vector-borne diseases in reindeer (Rangifer tarandus) Bolshezemelskaya and Malozemelskaya tundra.Materials and methods. The research was carried out in 2022–2023 on domesticated reindeer living in the Bolshezemelskaya and Malozemelskaya tundra of the Nenets Autonomous Okrug and the Komi Republic. Stabilized blood was obtained from animals by random sampling and PCR studies were performed for the presence of genetic material of pathogens of the genera Anaplasma, Babesia and Theileria.Results and discussion. The DNA of the causative agent of anaplasmosis was isolated from 14.3% of reindeer from Malozemelskaya (family-tribal community «Vy Tu» (VTU) and «Opseda» (OPS)) and 30.6% of Bolshezemelskaya tundra (Аgricultural production cooperative «Harp» (HARP) and Collective Farm «Izhemsky olenevod and Co» (IZHM)). To a greater extent, vazhenki and calves were infected with anaplasmosis, to a lesser extent – choirs. Genetic material of Babesia pathogens was found in 53.1% of VTU and OPS deer and 36.7% of HARP and IZHM, while babesiosis was most often observed in the chorus group. Teileriosis was found in 10.2% and 4.1% of animal samples among the herds of the Malozemelskaya and Bolshezemelskaya tundra, respectively. The genetic material of the causative agent of teileriosis was isolated mainly from the blood obtained from calves. The causative agent of theileriosis was not found in the biological material of the choirs. The presence of DNA Anaplasma spp. and Babesia spp. in one sample, the proportion of deer from Malozemelskaya tundra herds was 2.4%, from Bolshezemelskaya – 26.5%. The combined course of babesiosis and teileriosis was found to be 8.2% only in VTU and OPS deer. Thus, studies have shown that vector-borne diseases is widespread among the reindeer of the studied farms of the Bolshezemelskaya and Malozemelskaya tundra.
Neuropeptides of root-knot nematodes: functional significance in parasite locomotions (short review)
Authors: Milyutina T. A. , Udalova Zh. V. 
Published: December 2023

The purpose of the research is to analyze the literature devoted to the study of the physiological role and functional significance of biologically active substances: FMRFamide-like neuropeptides in the locomotion of root-knot nematodes Meloidogyne incognita, M. minor, M. hapla and M. graminicola using immunological, phylogenetic, molecular and bioinformatic research methods.Results and discussion. The present work shows the importance of endogenous FMRFamide-like neuropeptides (FLPs) in such behavioral reactions of plant nematodes as locomotion, which ensures the vital activity of plant parasites; the functional significance of flp genes in the neurobiology of root-knot nematodes is discussed. It was especially noted that the main physiological and functional characteristics of endogenous FLP in root-knot nematodes were obtained as a result of studies of the functional role of the flp genes encoding these neuropeptides. In the nematodes M. incognita and M. graminicola, components of the peptidergic nervous system were identified in the nervous structures: FMRFamide-like positive immunoreactivity, FLP, flp genes encoding neuropeptides, and G-protein-coupled receptors (GPCR) activated by these neuropeptides. It was shown that the main functional characteristics of endogenous FLPs in nematodes were obtained using one of the methods of reverse genetics, i.e., flp genes knockdown in shadow by means of RNA-interference. It has been established that FLP cause two types of physiological effects on the somatic muscles of root-knot nematodes – stimulation of the locomotor activity of the muscles and its inhibition. In most works, the data obtained on the physiological effects of neuropeptides on the locomotor activity of phytonematodes are considered with a view to their possible use in the development of new targeted anthelmintic drugs.
Study of subchronic oral toxicity of Altric-Extra drug in laboratory animals
Authors: Golovin V. V. , Abramov S. V. , Balyshev A. V. , Lagereva E. V. 
Published: December 2023

The purpose of the research is to determine main toxicological parameters in repeated intragastric administration of Altric-Extra for veterinary use to laboratory outbred rats.Materials and methods. White outbred rats were used as a test system in the study. The experiment used clinical, toxicological, biochemical and morphological research methods.Results and discussion. Altric-Extra doses of 325 and 650 mg/kg were toxic for the laboratory animals. When administered daily intragastrically to the rats in the above doses, the drug had a negative effect on the functional status of the hemopoietic organs, and excretory and digestive systems. The main target organ for this drug is the thymus. Functional disorders in the above organs and systems are irreversible as evidenced by the post-mortem examination, general blood analysis, and biochemical blood test obtained 10 days after the drug administration was completed.
Factors Affecting Job Satisfaction of Employees in Government Sector Organizations
Authors: Shiv Kumar Tripathi  , Dr. Ramesh Kumar Chaturvedi  
Published: December 2023

Job may be defined as a specific task done as part of the routine of one's occupation or for an agreed price. Job is a social expectation and social reality to which people seem to confirm for maintaining their livelihood. It not only provides status and psychological satisfaction to the individuals but also binds them to the society. Job satisfaction is a person’s attitude towards the job. Job satisfaction means measurement of excellence to which an employee feels contended and happy about his work and the conditions in which it has to be done.
The main purpose of the study is to investigate the determinants like encouragement, management, working condition and training as the various facets of employee job satisfaction which plays a major role for employee performance. A quantitative approach is used in this study. A Pearson correlation research design and survey method is used to collect data. A research model and four hypotheses were developed. Regression analysis was used to test the hypotheses.
The study found the implementation of independent variables like encouragement, management, working condition and training by public sectors enterprises. for maintaining the job satisfaction of employees in the organization. All of the predictor variables were significantly related to the success of employee performance.
Korelasi Antara Tax Planning Dan Tax Management Dengan Corporation Size Sebagai Variabel Kontrol
Authors: Susanto Wibowo  , Rr. Dian Anggraeni  , Salikim  , Irwan  
Published: December 2023

Penelitian ini bertujuan untuk memperoleh bukti empiris tentang korelasi antara tax planning, corporate size dengan profit management sebagai variabel kontrol perusahaan manufaktur barang konsumsi yang terdaftar di Bursa Efek Indonesia tahun 2022.
Metode penelitian yang digunakan yaitu; teknik pengambilan sampel menggunakan metode purpose sampling. Populasi dalam penelitian ini adalah seluruh perusahaan manufaktur barang konsumsi yang terdaftar di Bursa Efek Indonesia tahun 2022. Jumlah data sampel yang memenuhi syarat sebanyak 22 perusahaan, selebihnya tidak memenuhi syarat. Teknik analisis data menggunakan uji statistik; deskriptif, normalitas data dan uji korelasi parsial
Hasil penelitian menunjukkan bahwa hubungan antara Tax planning dengan profit margin tidak signifikan dan berhubungan positif lemah. Kemudian hubungan antara Tax planning dengan profit margin dengan variabel kontrol corporate size tidak signifikan dan ada berhubungan positif kuat sekali.
Pengaruh Motivasi Dan Kelompok Rujukan Terhadap Minat Melanjutkan Pendidikan Profesi Akuntansi (PPAk) Dengan Prestasi Akademik Sebagai Variabel Moderasi
Authors: Melvin Rahma Sayuga Subroto  , Inganatut Toyibah  
Published: December 2023

Penelitian ini bertujuan untuk:(1) Pengaruh Motivasi terhadap Minat Mahasiswa Akuntansi Mengikuti Pendidikan Profesi Akuntansi (PPAk); (2) Pengaruh Kelompok Rujukan Minat Mahasiswa Akuntansi Mengikuti Pendidikan Profesi Akuntansi (PPAk); (3) Pengaruh prestasi akademik memoderasi motivasi terhadap minat mahasiswa akuntansi melanjutkan Pendidikan Profesi Akuntansi (PPAk) ; (4) Pengaruh prestasi akademik memoderasi pengaruh biaya pendidikan terhadap minat mahasiswa akuntansi melanjutkan Pendidikan Profesi Akuntansi (PPAk). Sampel yang digunakan dalam penelitian ini yaitu sebanyak 75 mahasiswa. Metode analisis data yang digunakan adalah analisis deskriptif dan Structural Equation Modelling (SEM) dengan Partial Least Square (PLS) dengan alat analisis Smart PLS 4.0. Hasil penelitian menunjukkan bahwa variabel motivasi berpengaruh positif dan signifikan terhadap minat melanjutkan PPAk. Variabel Kelompok rujukan berpengaruh positif dan signifikan terhadap minat melanjutkan PPAk. Variabel prestasi akademik mampu memoderasi pengaruh motivasi terhadap minat melanjutkan PPAk. Variabel prestasi akademik mampu memoderasi pengaruh Kelompok rujukanterhadap minat melanjutkan PPAk.
CONTRIBUIÇÃO DE UM PROJETO DE LEITURA NA EDUCAÇÃO SUPERIOR PARA FORMAÇÃO DE PROFESSORES DA EDUCAÇÃO BÁSICA
Authors: Bodolay Adriana Nascimento , Honório Gontijo Cunha Yanna Karlla 
Published: December 2023

O presente trabalho consiste numa reflexão sobre os resultados obtidos na oferta de um curso de leitura a distância para alunos da Unipampa, bem como as contribuições desse projeto na formação de futuros professores de educação básica de Língua Portuguesa. Partimos do pressuposto de que o contato com os problemas de leitura apresentados pelos alunos ingressantes na educação superior possa servir como ponto de partida para a elaboração de atividades de leitura para a educação básica. Como principal resultado das ações do projeto, ressalta-se a oferta de oficinas ministradas pelos alunos bolsistas do grupo de trabalho a professores das redes municipais de Alegrete e Uruguaiana, que foram avaliadas de forma positiva por todos os participantes. PALAVRAS-CHAVE: leitura, educação superior, formação de professores
RESENHA
Authors: Jesus Osvaldo Freitas de 
Published: December 2023

O TEMPO CEDE LUGAR AO ESPAÇO Sphären (Esferas) é uma trilogia que deixa transparecer o fôlego de Peter Sloterdijk ([1]). São 2.759 páginas, escritas com arte e estilo e publicadas pela Editora Suhrkamp.
A UTILIZAÇÃO DO AMBIENTE VIRTUAL DE APRENDIZAGEM MOODLE EM UMA INSTITUIÇÃO DE ENSINO SUPERIOR PÚBLICA
Authors: Sebastião Ana Paula Ferreira 
Published: December 2023

Os ambientes virtuais de aprendizagem têm potencial para desempenhar um importante papel na maneira de ensinar e aprender, por permitirem não só a utilização de tecnologias para uma simples disponibilização de conteúdo, como também a comunicação síncrona e assíncrona em cursos ou disciplinas presenciais, a distância ou semipresenciais, além do gerenciamento de cursos. O objetivo deste artigo é relatar uma investigação sobre o uso do ambiente virtual de aprendizagem Moodle pelos professores de uma instituição de ensino superior pública. Para esta investigação, foi analisado um questionário enviado para os professores que utilizam o ambiente. Após a análise dos dados coletados, percebe-se que os docentes são receptivos ao uso do Moodle e desejam tornar o espaço mais significativo para os alunos que, devido à facilidade de uso e multiplicidade de recursos disponíveis nas redes sociais atuais, exigem do Moodle esses mesmos recursos. Porém, apesar das oficinas oferecidas pela instituição para o uso do Moodle, os docentes ainda apontam dificuldades para o uso das ferramentas disponibilizadas no ambiente. Conclui-se que há necessidade de promover programas de formação de professores para o uso das tecnologias de informação e comunicação, devendo-se ter a preocupação de criar uma comunidade de aprendizagem entre os docentes para que eles possam trocar suas experiências a fim de desenvolver e promover práticas significativas para si mesmos e seus alunos. Palavras-chave: Ambiente Virtual de Aprendizagem. Moodle. Educação a distância. Educação on-line. Professores universitários.
OPTIMAL APPROACHES FOR LOCAL TREATMENT OF GUNSHOT WOUNDS TO FACILITATE EARLY WOUND HEALING
Authors: Ivanova G.O. , Dudchenko M.O. , Kravtsiv M.I. , Ivashchenko D.M. , Shevchuk M.P. , Zezekalo Y.O. , Prykhidko R.A. 
Published: December 2023

Gunshot wounds comprise a significant category of injuries resulting from firearm use, involving not only the impact of the blast wave but also damage from metal and secondary tissue fragments. This topic remains highly relevant today, as the appropriateness of local and surgical treatments plays a crucial role in the prompt regeneration of damaged tissues, prevention of purulent complications, swift closure of wound defects, and the optimal restoration of organ function, thereby reducing disability rates for patients.
This study aims to compare and determine the clinical effectiveness of traditional dressings with antiseptic (Study Group I), hydroactive superabsorbent dressings (Group II), and Vacuum-Assisted Closure (VAC-therapy) (Group III) to provide cleansing of gunshot wounds, prepare the wound surface for skin plastic surgery, prevent secondary necrosis, purulent complications, and ensure the rapid rehabilitation of patients.
The study included 154 wounded individuals, divided into three groups, with an age range spanning 18 to 50 years. Following our study, it can be inferred that the use of Vacuum-Assisted Closure (VAC-therapy) proves most effective in treating gunshot wounds. This method stimulates the early growth of granulation tissue, with mature granulation tissue evident as early as the 4th day, in contrast to the use of hydroactive dressings (on the 6th day) and traditional gauze material with an antiseptic (on the 7th day). VAC-therapy facilitates marginal epithelization and wound contraction, preventing the development of secondary necrosis and severe purulent complications. Moreover, this approach requires shorter-term antibiotic therapy, exhibits the lowest rate of complications post-repair of a wound defect, and reduces the rehabilitation period for the wounded.
DEVELOPMENT OF A STRATIFICATION SYSTEM FOR SEVERE ACUTE PANCREATITIS IN THE FIRST DAY OF ITS ONSET
Authors: Kerbazh N. 
Published: December 2023

Introduction. Acute pancreatitis stands as one of the prevalent acute inflammatory diseases of the abdominal cavity, marked by a diverse range of clinical presentations and the risk of developing persistent organ failure is too high even in its early stages. At present, the widely adopted framework for assessing acute pancreatitis is the 2012 revised Atlanta classification. However, distinguishing between moderately severe and severe acute pancreatitis within this classification necessitates a minimum of 48 hours to determine the persistence of organ failure. Consequently, the primary challenge in contemporary acute pancreatitis diagnosis and treatment lies in the imperative task of early-stage prognosis and effective stratification of disease severity.
Objective of this investigation is to determine the availability of optimal parameters of clinical and instrumental examination methods in order to predict the course of acute pancreatitis in the first day of its onset by conducting a statistical analysis of the studies performed.
Materials and methods. The assessment the state of microcirculation in patients by the method of laser Doppler flowmetry was carried out using the LAKK-02 device according to the specified methodology. Patients were also subjected to general clinical and instrumental examination. In order to study the influence of indicators on the severity of the disease, the paired correlation coefficients of each of them were calculated, after which, for the parameters with the closest connection, a multiple linear correlation-regression model was built and the multiple correlation coefficient with the severity of the disease was calculated.
Results. The following parameters have the most significant influence on the severity of the disease on the first day: findings of laser Doppler flowmetry C (A/M), systemic inflammatory response syndrome criteria, hematocrit, hydrothorax/peritonitis. In the complex analysis, the multiple correlation coefficient is 0.803, which indicates a significant relationship between the factors included in the model and the degree of severity. The coefficient of determination points out that the degree of severity is 64.5% dependent on the indicators included in the model.
Conclusions. The obtained results of the study indicate the presence of a complex influence of the criteria of laser Doppler flowmetry C (A/M), criteria of the systemic inflammatory response syndrome, hematocrit, hydrothorax/peritonitis on the severity of the disease in patients with acute pancreatitis within the first day of the disease onset that underscores the potential for early-stage preliminary stratification of acute pancreatitis severity based on these criteria.