bluuebunny/crossref_metadata_2025_split huggingface dataset:
Design and validation of analytical methods for quantitative determination of active ingredients in extemporal combined medicine in spray form
Authors: Cherniakova Valeriia , Myhal Artem , Rudiuk Vitalii , Studenyak Yaroslav , Kryvanych Oleksandr , Bevz Nataliia , Georgiyants Victoriya 
Published: January 2024

The aim of the work was the development and study of the validation characteristics of the method of quantitative determination of phenylephrine hydrochloride, nitrofural and diphenhydramine hydrochloride when they are simultaneously present in an extemporaneous combined medicinal product in the form of a spray using liquid chromatography method.
Materials and methods. Agilent 1260 liquid chromatographs, equipped with a diode-matrix and UV detector from the company "Agilent technologies", USA. Chromatographic columns 250×4.6 mm filled with octadecylsilyl silica gel for chromatography (Zorbax StableBond SB-Aq, Agilent company), mobile phase - 0.1 % aqueous solution of trifluoroacetic acid R - methanol R, elution mode - gradient; mobile phase speed – 1.2 ml/min; the detection wavelength is 220 nm.
Results. The determined chromatographic conditions ensure proper separation of the peaks of the substances to be determined: phenylephrine hydrochloride, nitrofural and diphenhydramine hydrochloride in their joint presence, and do not have a negative effect on the quantitative assessment of their content. Validation tests were conducted to confirm the suitability of the analytical method for the performance of the task - control of the quantitative content of active substances in the combined medicinal product in the form of a spray. The determined validation characteristics indicate that the method is characterized by appropriate specificity, linearity, correctness and convergence in the range of application for phenylephrine hydrochloride (range 0.499-0.749 mg/ml, ΔZ=0.44 ≤ max ΔZ=3.20, d=0.22 ≤ max d=1.02, a=0.01 max a=5.1, r = 0.9997 min r= 0.9924), nitrofural (range 0.154-0.231 mg/ml, ΔZ=0.44 ≤ max ΔZ=3.20, d=0.62 ≤ max d=1.02, a=0.0006 max a=5.1, r = 0.9996 min r= 0.9924) and diphenhydramine hydrochloride (range 0.499-0.749 mg/ml, ΔZ=0.50 ≤ max ΔZ=3.20, d=0.05 ≤ max d=1.02, a=0.076 max a=5.1, r = 0.9999 min r= 0.9924).
Conclusions. An analytical technique for the quantitative determination of phenylephrine hydrochloride, nitrofural and diphenhydramine hydrochloride when simultaneously present in an extemporaneous combined medicinal product in the form of a spray by the method of high-performance liquid chromatography was developed. The determined validation parameters confirm the correctness of the methodology. The proposed HPLC technique was used to study the chemical stability of the spray for the treatment of allergic rhinitis
Case report on prolonged kidney graft survival without immunosuppressive therapy after allogeneic hematopoietic stem cell transplantation
Authors: Shmarina N. V. , Borovkova N. V. , Stolyarevich E. S. , Vasilyeva V. A. , Storozhev R. V. , Dmitriev I. V. , Balkarov A. G. , Parovichnikova E. N. 
Published: January 2024

Background. The possibility of inducing immunological tolerance in allogeneic organ transplant recipients is a research goal of the transplantology community, as it will ensure the likelihood of complete engraftment of a foreign organ. However, such a task presently remains difficult to accomplish.Objective: to demonstrate longterm kidney graft survival without signs of acute rejection and without immunosuppressive therapy in a patient who underwent allogeneic hematopoietic stem cell transplantation (allo-HSCT) from a haploidentical donor for post-transplant lymphoproliferative disorder (PTLD).Methods and materials. Recipient’s graft function was assessed using clinical, laboratory, instrumental and pathomorphological examination methods. Results. With no immunosuppressive therapy for more than four years, the kidney recipient showed stable, satisfactory graft function.Conclusion. The described clinical case demonstrates the development of immunological tolerance to a kidney graft in a recipient of allogeneic hematopoietic stem cells (HSCs).
A case of successful orthotopic heart retransplantation in an 11-year-old child
Authors: Ivanov I. Yu. , Kalmykov V. S. , Grebennik V. K. , Ismail-zade I. K. , Ishmukhametov G. I. , Dyachenko Ya. A. , Maistrenko N. S. , Dzhum V. I. , Khatnyuk O. A. 
Published: January 2024

Objective: to present a clinical case of an 11-year-old child who underwent repeat heart transplantation (HT) at Almazov National Medical Research Centre in St. Petersburg, Russia.Materials and methods. A case of successful heart retransplantation in an 11-year-old child with cardiac allograft vasculopathy (CAV) is presented.Results. The postoperative period after heart retransplantation had no significant differences with the postoperative period of primary heart recipients. The complexity of the intraoperative stage was determined by pronounced adhesions. As part of preoperative preparation, the patient underwent chest CT scan, which, in our experience, allows us to evaluate the heart syntopy and, in turn, is an important preparatory stage in planning repeat interventions.Conclusion. Our first experience of cardiac retransplantation in pediatric patients suggests that repeat HT is the most optimal treatment for pediatric patients with CAV and requires more thorough preoperative preparation.
A 5-year single-center experience in heart transplantation in Rostov oblast
Authors: Korobka V. L. , Kostrykin M. Yu. , Duzhikov A. A. , Shamkhanyants V. D. , Lobachev D. K. , Kotov O. V. , Kartashov A. A. , Sumin A. V. , Gusnay M. V. , Trapeznikova A. I. , Kudryashova E. A. , Korobka R. V. 
Published: January 2024

Objective: to evaluate the outcomes of heart transplants performed at Rostov Regional Clinical Hospital within five years.Materials and methods. Between 2017 and 2022, 29 orthotopic heart transplants (HT) were performed in our clinic. Heart failure was caused by postinfarction cardiosclerosis (21 cases, 72.4%) and dilated cardiomyopathy (8 cases, 27.6%). Among the recipients, 27 (93.1%) were men and 2 (6.9%) were women. Mean age was 53.14 ± 8.7 years (34 to 67 years). All patients received quadruple-drug immunosuppressive therapy, including induction with monoclonal antibodies; calcineurin inhibitor, mycophenolic acid, and corticosteroid were used after HT.Results. In-hospital mortality was 10.34% (n = 3). The causes of death were multiple organ failure and infectious and septic complications. After discharge, 4 (13.8%) recipients died over 5 years. Rejection reaction with the development of graft dysfunction (3 recipients, 75%), infectious and septic complications (1 recipient, 25%) were the causes of death in the long-term period. The survival rate was analyzed according to the Kaplan–Meier estimate. One-year survival was 80.9%. Three-year survival rate corresponded to the 5-year survival rate – 70.56%. Five-year survival of patients surviving the first year after HT was 86.1%. Maximum follow-up period was 64 months.Conclusion. HT continues to be the gold standard for patients with end-stage heart failure. Five-year HT experience in our center has shown a survival rate that is comparable to that of the International Society for Heart and Lung Transplantation (ISHLT).
Seismic Thermography
Authors: Lebedev Sergei , Fullea Javier , Xu Yihe , Bonadio Raffaele 
Published: January 2024

ABSTRACT
Variations in temperature within the Earth are of great interest because they indicate the thickness and, consequently, mechanical strength of the lithosphere and density variations and convection patterns in the sublithospheric mantle. Seismic tomography maps seismic velocity variations in the mantle, which strongly depend on temperature. Temperatures are, thus, often inferred from tomography. Tomographic models, however, are nonunique solutions of inverse problems, regularized to ensure model smoothness or small model norm, not plausible temperature distributions. For example, lithospheric geotherms computed from seismic velocity models typically display unrealistic oscillations, with improbable temperature decreases with depth within shallow mantle lithosphere. The errors due to the intermediate-model nonuniqueness are avoided if seismic data are inverted directly for temperature. The recently developed thermodynamic inversion methods use computational petrology and thermodynamic databases to jointly invert seismic and other data for temperature and composition. Because seismic velocity sensitivity to composition is much weaker than to temperature, we can invert seismic data primarily for temperature, with reasonable assumptions on composition and other relevant properties and with additional inversion parameters such as anisotropy. Here, we illustrate thus-defined seismic thermography with thermal imaging of the lithosphere and asthenosphere using surface waves. We show that the accuracy of the models depends critically on the accuracy of the extraction of structural information from the seismic data. Random errors have little effect but correlated errors of even a small portion of 1% can affect the models strongly. We invert data with different noise characteristics and test a simple method to estimate phase velocity errors. Seismic thermography builds on the techniques of seismic tomography and relies on computational petrology, but it is emerging as a field with its scope of goals, technical challenges, and methods. It produces increasingly accurate models of the Earth, with important inferences on its dynamics and evolution.
Basic new born and antenatal screening for aspirational districts: unique methods of management and treatment of inherited disorders
Authors: Uppal Komal , Joshi Chandrika , Polipalli Sunil Kumar , Kumar Somesh , Jindal Ankur , Gupta Sangeeta , Verma Amar , Kapoor Seema 
Published: January 2024

Background: Early screening, diagnosis and management program can contribute in reducing the burden of genetic disorders which can lead to early neonatal death or long-term disability in the vulnerable areas. UMMID (Unique Methods of Management and treatment of Inherited Disorders) and NIDAN (National Inherited Diseases Administration), aimed at developing a community level program for need assessment and to evaluate the feasibility of basic screening for some genetic/endocrine disorders in high-risk population.
Methods: UMMID was carried out at the aspirational district Ranchi, Jharkhand for 3 years (2019-2022) to perform newborn screening (NBS) in <7 days old newborn babies for 5 metabolic disorders and to screen antenatal mothers for prevention of thalassemia and other hemoglobinopathies.
Results: G6PD deficiency being more prevalent in Ranchi district out of five metabolic disorders screened. 13.6% of screen positive cases were confirmed positive for hemoglobinopathies. c.20 A>T is the most common mutation found among carriers.
Conclusions: This initiative underscores the need of such screening programs in aspirational districts to manage and prevent these disorders effectively.
Burnout Among Social Workers. Exploratory Research in Botosani City
Authors: Bădărău Oana Lăcrămioara , Zosineanu Maria 
Published: January 2024

The present work aims to explore the presence of symptoms associated with the burnout syndrome in a number of 24 social workers who work within the General Direction for Social Work and Child Protection (DGASPC) Botoșani. The objectives of the investigation were the following: a) exploring possible stress factors at the organizational level according to the six categories identified by Christine Maslach and Leiter Michael (1999) and b) identifying the level of self-perceived stress by social workers.
The results of the study indicate a favorable self-perception of the existence of burnout or at least an increased level of stress felt at work, by identifying some variables evaluated as unfavorable for the achievement of work in a fair, transparent and balanced framework.
The Entirety and the Interdisciplinarity in the Sociology of Petre Andrei
Authors: Chiuchi Oana Mariana 
Published: January 2024

The present paper is a synthetic presentation of Petre Andrei's conception regarding the integrality and interdisciplinarity of sociology as a science. Thus, the concept of completeness of sociology is summarized related to the object of study and also as a specific research method in the complex process of sociological investigation of the social life, as a set of components, conditions and types of activities. Also, the notion of the interdisciplinarity of sociology with other socio-human sciences (philosophy, history, psychology, pedagogy) is argued, as it emerges from the work of the Romanian sociologist.
Metacognition and Metamemory
Authors: Pruteanu Alice , Chiracu Alina 
Published: January 2024

The discovery and theoretical development of metacognition has been an important step in cognitive research in recent decades.
Metacognition performs several functions, identifying three major categories of it: Metamemory and metacomprehension, problem solving, critical thinking. Although this taxonomy cannot cover the many types of metacognition, it nevertheless reflects the extensive role of the process in important cognitive contexts.
Reconfiguración de saberes: Vivencia académica de las reformas universitarias en la UTP 1980-1994
Authors: Agudelo Castañeda Natalia , Correa Ramírez Jhon Jaime , López García Edwin Mauricio 
Published: January 2024

Objetivo: Explorar el cambio experimentado en la educación superior colombiana desde los años ochenta, específicamente a través del análisis de la aplicación práctica del Decreto Ley 80/1980 a nivel regional y local. El objetivo principal es llenar un vacío de conocimiento existente sobre el impacto de este decreto en las instituciones educativas, destacando su influencia en la cotidianidad universitaria.

Originalidad o Aporte:
Se enfoca en un aspecto poco explorado de la reforma universitaria en Colombia, centrándose en la experiencia regional y local de la Universidad Tecnológica de Pereira. Se busca proporcionar una perspectiva completa sobre el desarrollo institucional y los efectos en los distintos estamentos universitarios, contribuyendo así al conocimiento existente sobre las reformas de los ochenta y noventa.

Método: El método de investigación es de tipo histórico y se basa en el análisis y contraste de fuentes primarias, utilizando el archivo institucional de la Universidad Tecnológica de Pereira. Se accede a documentos de los Consejos Superior y Académico, así como a testimonios de profesores y personal administrativo. Este enfoque permite contrastar el desarrollo institucional con la experiencia de los distintos estamentos frente a los cambios introducidos por el Decreto Ley 80/1980.

Estrategia de Recolección de Información: Las estrategias de recolección de información se centran en el análisis detallado de documentos institucionales y testimonios. Se buscó obtener una perspectiva completa sobre la implementación de las reformas, utilizando la Universidad Tecnológica de Pereira como caso de estudio representativo de la experiencia universitaria regional durante el periodo en cuestión.

Conclusiones: En las conclusiones, se destaca la oportunidad de reflexionar sobre cómo las reformas universitarias de los ochenta y noventa, enmarcadas por el Decreto Ley 80/1980, otorgaron un cariz neoliberal a la cotidianidad universitaria. Se enfatizan los impactos en la vida directiva, docente y estudiantil, utilizando la experiencia de la UTP como prisma para comprender estos cambios en la educación superior.
“Tus pies te llaman”: Impacto de una intervención para mejorar autocuidado de pies en diabetes
Authors: Bañuelos-Barrera Patricia , Ochoa-Martínez César , Domínguez-Chávez Claudia Jennifer , Lara-Esqueda Agustín , Ortiz-Rivas Miriam Karina 
Published: January 2024

Objetivo: Evaluar el impacto de una intervención educativa individualizada en los conocimientos, autocuidado de los pies, control glucémico, riesgo de ulceración e incidencia de úlceras en pacientes con diabetes tipo 2.
Material y Métodos: Estudio de intervención realizado en 65 pacientes ambulatorios, mayores de 35 años, con diabetes tipo 2, distribuidos aleatoriamente en dos grupos: grupo control (35) que recibió un manual de cuidado de los pies, y grupo intervención (30) quien recibió la intervención, un kit de cuidado de los pies y un manual. El seguimiento se realizó a los tres y seis meses después de la intervención. El análisis estadístico incluyó la prueba de Chi-cuadrado, prueba de Wilcoxon y prueba ANOVA de mediciones repetidas.
Resultados: La intervención mejoró los conocimientos y el autocuidado de pies en el grupo de intervención, con diferencias significativas entre grupos (p=.001), pero no mejoró el control glucémico ni el riesgo de ulceración.
Conclusiones: El programa “tus pies te llaman” fue efectivo parcialmente, este estudio puede ser replicado en instituciones de primer nivel de forma ordinaria para mejorar el autocuidado y prevenir la ulceración del pie a mediano plazo.

Palabras clave: Diabetes tipo 2; Conocimiento; Autocuidado; Pie; Estudios de intervención.
Influencia de la percepción de la calidad de atención sobre la salud en estudiantes universitarios
Authors: Rojas-Armadillo María de Lourdes , Torres-Soto Nissa Yaing , Martínez-Ramírez Beatriz , Suárez Lara Gabriela Alejandrina , Orozco González Claudia Nelly , Peña Torres Edgar Fernando 
Published: January 2024

Objetivo: La percepción de la calidad de atención al paciente es una línea de atención que ha quedado relegada en la población universitaria, ya que estos cuentan con el derecho a la atención médica por parte de la universidad, sin embargo, existen factores tanto del sector salud y universitarios que disminuyan las prácticas saludables en los estudiantes universitarios. El objetivo del presente estudio fue evaluar como perciben la calidad de atención en salud sobre la percepción y las prácticas de salud en los estudiantes de la Universidad de Quintana Roo a través de un modelo de ecuaciones estructurales.
Materiales y Métodos: Se encuestaron a 401 estudiantes de la Universidad Autónoma del Estado de Quintana Roo, mayores de 20 años, 70% mujeres y 30% hombres. Se aplicaron las escalas de percepción de la calidad de atención en el servicio médico, calidad del servicio de promoción de salud por parte de la universidad y la percepción de salud en el estudiante; mediante un modelo estructural se analizó la relación entre la calidad de los servicios con el cuidado de la salud.
Resultados: La percepción de una adecuada calidad de atención en las instituciones de salud y en la universidad influye significativamente en la percepción positiva de salud de los estudiantes (p<0.05). Por otra parte, se encontró que un 70% de los estudiantes no cuentan con acciones preventivas de salud.
Conclusión: La percepción de salud y las prácticas preventivas pueden verse influenciadas por la calidad en los servicios que se les ofrecen en la institución de salud y en la universidad.

Palabras-clave: Calidad de atención, Estudiantes, Modelo de ecuaciones, Salud.
Military training in modern geopolitical realities
Authors: Fedotov B. V. 
Published: January 2024

Introduction. An assessment is made of the role of military training in terms of the geopolitical stability of Russia as an important player on the world stage. The interrelation of war and military affairs from the factors of domestic and foreign policy is shown.Purpose setting. The problem of military training in the conditions of military confrontation with the countries of the «collective West» is put forward as the fundamental task of the study. Analyzing the reforms of the country's military organization, starting from the 2000s of the XX century, the author focuses on the fact that the sovereignty of the state can be ensured only if there is a combat-ready Armed Forces, where an important role belongs to a full-fledged military mobilization reserve. Two components of the personnel of the Ministry of Defense – professional military personnel and those liable for military service who are in the reserve – act as a condition and guarantor of their readiness to repel aggression. Therefore, their military training should be organized taking into account changes in the field of military affairs, and the system of military training itself should cover the entire population.Methodology and methods of the study. The methodology is based on the analysis and comparison of the experience of military reforms by the top leadership of the military department of the Russian Federation since the early 2000s and the solution of these issues at the present time and in the near future. The dialectical approach helps the author to show the causal relationship of military reforms in Russia and their impact on the state of military educational activities, and, accordingly, the quality of training of military personnel.Results. The results of the study should be considered a demonstration of military training in Russia from the point of view of the changed conditions of geopolitics.Conclusions. The outcomes that conclude this study sum up the full range of information presented that, in order to ensure long-term peace, a country must have a reliable military capability based on militarily trained human resources. It is not by chance that the article analyzes the nature of the special military operation in Ukraine. This experience, as well as the experience of Russia's participation in other wars and military conflicts, allows us to substantiate the conclusions about the organization of an effective system of professional military training in Russia.
Reading and reading practices of modern students (based on the materials of scientific-research discourse)
Authors: Vikhreva G. M. 
Published: January 2024

Introduction. The increase of research interest in the analysis of student reading practices, observed in the last decade, is due to large-scale transformation processes in the field of book and reading. In connection with the emergence of new forms of texts existence, reading strategies are changing significantly, primarily among young people, since they are able to quickly and effectively master new skills of reading behavior, assimilate modern types of knowledge and apply new teaching methods. At the same time, a commonly recognized fact and one of the urgent modern problems is a decrease in the intellectual and cultural level of Russian students. The situation of youth «non-reading» aggravates every year. The library as the main organizer of reading in the society traditionally includes the reader and the dynamics of reading behavior in the sphere of its research interests. An important stimulus for the interest in the reading strategies of young students is the fact that they constitute the largest audience of most libraries today.Purpose setting. The purpose of this article has been the analysis of current scientific publications that provide material for improving the processes of library and information services for students, stimulating their reading activity in the context of multimedia culture development.Methodology and methods of study. Since the study of the actual social phenomenon of reading practices is an interdisciplinary character, the monitoring of scientific discourse on this theme for successful development of dialogue forms of interaction between library specialists and student readers was carried out.Results. Such significant facts are noted, as antinomy of modern reflections on reading activity, presence of ambivalent attitude towards reading in the today»s society, formation of a new, search and reference type of work with information in the student environment, subjectness of reading behavior of young people as the ability to independently determine the trajectory of their own reading, transform traditional reading practices into new communicative formats.Conclusion. The community of library specialists intensively looks for ways and modes of adaptation to new conditions of existence, actualizes tasks, reconsiders ideology of interaction with readers.