bluuebunny/crossref_metadata_2025_split huggingface dataset:
New Imidazo[4,5‐c]pyridine‐piperidine Hybrids as Potential Anti‐cancer Agents and In‐Silico Studies
Authors: Rejinthala Swathi , Endoori Srinivas , Thumma Vishnu , Mondal T. 
Published: January 2024

AbstractDesign and synthesis of a series of novel hybrid molecules that combine Imidazo[4,5‐c] pyridines with piperdines are presented in this paper. Total 17 derivatives were meticulously synthesized and characterized using 1H NMR, 13C NMR, MS and elemental analysis techniques. The in vitroanticancer activities are estimated by verifying their effectiveness against the MCF‐7 human breast adenocarcinoma and A549 lung cancer cell line, with cisplatin and doxorubicin serving as reference drugs. Several of these compounds demonstrated significant potential, displaying IC50 values within the range of 12.26–84.5 μM for A549, and 13.37–69.82 μM for MCF‐7. Notably, compound 11 bis found to be more potent than the standard drug cisplatin with an IC50 of 12.26±0.8 μM against A549 cells, while compound 11 d exhibited highest inhibition with an IC50 of 13.37±0.4 μM against MCF‐7 cells. Although its effectiveness was moderately lower when compared to doxorubicin, it still retained substantial anticancer activity. Molecular docking studies were performed to decouple the binding affinity and ligand interactions of the compounds with the estrogen receptor alpha (ERα) (PDB ID: 3ERT). The pharmacokinetic evaluation revealed favourable drug‐likeness properties for all the molecules, suggesting their potential as therapeutic agents.
Solid‐State Organic Fluorophore for Latent Fingerprint Detection and Anti‐Counterfeiting Applications
Authors: Durgi Nikita Kush , Pujar Prasad Pralhad 
Published: January 2024

AbstractA highly fluorescent material exhibiting solid‐state fluorescence is particularly important in detecting latent fingerprints (LFPs) and anti‐counterfeiting applications. Herein, we have synthesized a coumarin‐benzothiazole moiety 3‐(benzo[d]thiazol‐2‐yl)‐2H‐chromen‐2‐one (3‐BTC) to inspect its capability to visualize LFPs and work as an anti‐counterfeiting ink. The compound showed yellow‐greenish emission under UV excitation and good covertness under visible light conditions. With the help of the powder dusting method, the latent fingerprints were coated with 3‐BTC powder and images of the LFPs developed over various substrates including plastic, steel, aluminium plate, rubber, etc. under UV 365 nm light displayed good resolution be able to discern the patterns of all the levels 1–3. Apart from fresh fingerprints (taken within 10 seconds), aged (over 60 days) and incomplete eccrine LFPs were successfully visualized using 3‐BTC powder. Anti‐counterfeiting ink prepared using 3‐BTC also proved to be a promising candidate as an anti‐counterfeiting ink. Various types of paper materials, including tissue paper, printing paper, newspaper, etc. were used for evaluating 3‐BTC as a satisfactory anti‐counterfeiting ink.
Effect of synthesis medium and synthesis conditions on physicochemical properties of hierarchical SAPO‐11 molecular sieve synthesized via fractional crystallization method
Authors: Dai Xiaojun , Cheng Yan , Liu Tingting , Mao Lingjuan 
Published: January 2024

AbstractSAPO‐11 molecular sieve has been widely used as the support of bifunctional catalyst for hydroisomerization of n‐alkanes because of its mild acidity and unique one‐dimensional pore structure, and has been widely used in industry. However, how to further improve and improve the physicochemical properties of SAPO‐11 molecular sieve is still worth studying. In this work, fractional crystallization method was used to synthesize graded SAPO‐11 molecular sieve. The effects of medium system, feed SiO2/Al2O3, crystallization time and crystallization temperature of the second crystallization process on the physicochemical properties of SAPO‐11 molecular sieve were investigated from the perspectives of crystallinity, textural properties and acidity. The suitable synthesis medium and the best synthesis conditions were determined. It is expected to provide reference for the fractional crystallization synthesis of high performance SAPO‐11 molecular sieve.
Stepwisely Assembled Multicomponent Fiber with High Water Content and Superior Mechanical Properties for Artificial Ligament
Authors: Huang Hao , Wang Weijie , Liu Zexin , Jian Hanxin , Xue Bing , Zhu Liping , Yue Kan , Yang Shuguang 
Published: January 2024

AbstractThe ligament, which connects bones at the joints, has both high water content and excellent mechanical properties in living organisms. However, it is still challenging to fabricate fibrous materials that possess high water content and ligament‐like mechanical characteristics simultaneously. Herein, the design and preparation of a ligament‐mimicking multicomponent fiber is reported through stepwise assembly of polysaccharide, calcium, and dopamine. In simulated body fluid, the resulting fiber has a water content of 40 wt%, while demonstrating strength of ≈120 MPa, a Young's modulus of ≈3 GPa, and a toughness of ≈25 MJ m−3. Additionally, the multicomponent fiber exhibits excellent creep and fatigue resistance, as well as biocompatibility to support cell growth in vitro. These findings suggest that the fiber has potential for engineering high‐performance artificial ligament.
Optimized three‐phase hollow fiber liquid‐phase automated microextraction and its application in ultra‐trace analysis of three pyrethroids in water and fruit samples using high‐performance liquid chromatography‐diode array detection
Authors: Nikdel Mohsen , Nezami Alireza , Yamini Yadollah , Nezhad Behnam Ghorbani , Nazaripour Ali , Baghani Matin , Rahimzadegan Milad 
Published: January 2024

AbstractIn the present manuscript, an automated three‐phase hollow fiber liquid‐phase microextraction followed by high‐performance liquid chromatography‐diode array detection is applied for the extraction and determination of three pyrethroids, deltamethrin, fenpropathrin, and permethrin in water and fruit samples. N‐dodecane was selected as a supported liquid membrane (SLM) and its polarity was adjusted by trioctylphosphine oxide one‐variable‐at‐a‐time method was used in order to achieve optimal hollow fiber liquid‐phase microextraction parameters such as type of organic acceptor phase, the composition of SLM, ionic strength of sample solution, extraction time, length of hollow fibers and stirring speed. Under the optimal conditions, the calibration curves for the three pyrethroids were plotted, and figures of merit of the proposed method were calculated. The linear dynamic ranges were in the range of 0.9–200, 0.75–200, and 1.5–200 μg/L for deltamethrin, fenpropathrin, and permethrin, with the coefficient of determination better than 0.998. The limits of detection were in the range of 0.3, 0.25, and 0.5 and the limits of quantification were in the range of 0.9, 0.75, and 1.5 μg/L for deltamethrin, fenpropathrin, and permethrin, respectively. The precision of the method was evaluated in terms of relative standard deviation at two different concentration levels 10 and 50 μg/L. The results of real sample analysis in cucumber exhibited high sensitivity, excellent sample clean‐up, favorable repeatability, and suitable accuracy.
Three‐dimensional printed biomimetic multilayer scaffolds coordinated with sleep‐related small extracellular vesicles: A strategy for extracellular matrix homeostasis and macrophage polarization to enhance osteochondral regeneration
Authors: Li Xu‐Ran , Deng Qing‐Song , Liu Po‐Lin , He Shu‐Hang , Gao Yuan , Wei Zhan‐Ying , Zhang Chang‐Ru , Wang Fei , Dou Xiao‐Qiu , Dawes Helen , Guo Shang‐Chun , Tao Shi‐Cong 
Published: January 2024

AbstractCartilage defects resulting from injury or degeneration are a common clinical problem, and due to its avascular nature, articular cartilage has poor self‐healing capacity. Three‐dimensional (3D) bioprinting has attracted great attention in tissue engineering. Melatonin (MT), a hormone mainly secreted at night, plays an important role in tissue repair. Small extracellular vesicles (sEV) are considered ideal drug delivery vehicles and MT‐sEV (sleep‐related sEV) have the potential ability to promote cartilage regeneration. Here, biomimetic multilayer scaffolds were fabricated using 3D bioprinting. A double network hydrogel, composed of methacrylated hyaluronic acid and gelatin methacryloyl (HG), was prepared. MT‐sEV and HG hydrogel were used to create a cartilage layer. A bone layer was formed using poly(ε‐caprolactone) and hydroxyapatite ultralong nanowires. Additionally, two bioinks were alternately printed at the interface layer. The results of RNA sequencing revealed the potential regulatory mechanisms. MT‐sEV showed promotional effects on cell migration, proliferation, chondrogenic differentiation, and extracellular matrix (ECM) deposition. Moreover, MT‐sEV altered macrophage polarization and regulated the expression of inflammatory cytokines. In vivo experiments demonstrated that the biomimetic multilayer scaffolds promoted cartilage regeneration. These experiments demonstrated the ability of MT‐sEV to regulate the immune microenvironment and promote the secretion of ECM, providing a promising strategy for cartilage regeneration.
School adjustment in adolescence explained by social support, resilience and positive affect
Authors: Azpiazu Lorea , Antonio-Aguirre Iratxe , Izar-de-la-Funte Iker , Fernández-Lasarte Oihane 
Published: January 2024

AbstractIn order to develop future academic-professional skills and later social and financial independence, an adequate adolescent school adjustment is essential. Therefore, it is necessary to identify the variables that contribute to its improvement in a stage characterised by its decrease. The aim of the present study is to analyse and compare two theoretical models to determine the prediction of teacher and peer support, resilience and positive affect to school adjustment, measured through emotional engagement, school integration problems and perceived academic performance. The design was cross-sectional and participants were 1397 adolescents in high school (M = 13.88, SD = 1.27). The results reveal that teacher and peer support, resilience and positive affect indirectly predict perceived academic performance through school integration problems and emotional engagement. The negative effect of emotional engagement and support from peers on school integration problems is particularly worth highlighting, along with the prediction of resilience on positive affect and that of support from teachers on emotional engagement. The theoretical and practical implications of these results are discussed.
Short-term middle Eocene (Bartonian) paleoenvironmental changes in the sedimentary succession of Olivetta San Michele (NW Italy): the response of shallow-water biota to climate in NW Tethys
Authors: Arena Luca , Giraldo-Gómez Victor M. , Baucon Andrea , Piazza Michele , Papazzoni Cesare A. , Pignatti Johannes , Gandolfi Antonella , Briguglio Antonino 
Published: January 2024

AbstractThis study focuses on the paleontological content of the middle Eocene (Bartonian) carbonate–siliciclastic sediments of the Capo Mortola Calcarenite Formation from Olivetta San Michele (Liguria, Italy). Along the succession, there are significant paleoecological changes triggered by the variation in neritic input as a consequence of tectonic and climatic instability. Among microfossils, nummulitids prevail, followed by orthophragmines, smaller benthic, and planktonic foraminifera, whereas mollusks and ichnofossils are the most abundant macrofossils. The sudden changes in the benthic communities due to the progressive increase in fluvial input are recorded throughout the sedimentary succession. An increase in water turbidity caused stressful conditions for autotrophic taxa, reducing their size and abundance. In contrast, filter feeders became dominant, suggesting an increase in dissolved and suspended nutrients. Ichnological analysis shows environmental fluctuations controlled by the transport of neritic material offshore, thus confirming the general deepening trend of the studied succession. In the upper part of the succession, we recorded an alternation between gravity flows and marly sediments that are interpreted as short-term alternations between low and intense precipitations. The gravity flows yield taxa such as larger benthic foraminifera (LBF), smaller benthic and planktonic foraminifera, mollusks, and corals. In turn, marls display only a few LBF and abundant smaller benthic and planktonic foraminifera. In these intervals, the increase in planktonic foraminifera also suggests a deepening of the carbonate ramp coinciding with a reduction of light that did not favor the development of LBF. These changes are probably related to the climatic dynamics that occurred in the Bartonian in the western Tethys.
Exploring students’ acceptance and continuance intention in using immersive virtual reality and metaverse integrated learning environments: The case of an Italian university course
Authors: Di Natale Anna Flavia , Bartolotta Sabrina , Gaggioli Andrea , Riva Giuseppe , Villani Daniela 
Published: January 2024

AbstractImmersive virtual reality (IVR) and Metaverse applications are gaining attention in the educational field, showing potentials in transforming traditional learning methods by supporting active and experiential forms of learning. Our study, conducted within the context of an Italian university course, employs the Extended Expectation-Confirmation Model (EECM) as a theoretical framework to explore the key aspects of students’ acceptance and continued intention to use IVR and Metaverse integrated learning environments in educational settings. The EECM, which bridges the gap between pre-adoption expectations and post-adoption experiences, provides a comprehensive perspective for exploring technology adoption in education. Students’ attitudes were assessed before and after they completed an elective course offered by the university that delved into IVR and Metaverse applications. During the course, students explored the theoretical and practical applications of these technologies, engaging in a variety of experiences, from immersive relaxation exercises to immersive educational platforms in the emerging Metaverse. Contrary to common assumptions, pre-adoption factors like performance and effort expectancy had limited impact on expectancy confirmation. However, when students’ initial expectations matched their experiences, their perceptions of the technology’s usefulness, satisfaction, and confidence in its use were positively enhanced, influencing their continued intention to integrate these tools in education.
Critical environmental management accounting practices influencing service delivery of growing cities in a developing economy: a review and conceptual framework
Authors: Mukwarami Silas , van der Poll Huibrecht M. 
Published: January 2024

AbstractThe scope for environmental management accounting (EMA) has perpetually received attention in recent years, and it has become a pillar of sustainability in addressing environmental and service delivery challenges. Most scholars focused on EMA in a corporate context, limited attention has been given to local governments in available scholarly articles except for various initiatives by the United Nations to guide local governments in adopting and implementing sustainable environmental management practices. This has continued to affect the uptake of EMA in local governments, particularly in developing economies, as the question concerning the role of EMA practices (EMAPs) in environmental and service delivery remains unexplored. A systematic literature review (SLR) through the use of Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) to identify EMAPs and their role in promoting environmental and service delivery performance (SDP) in local governments was employed. Articles from Google Scholar and Scopus published between 2000 and 2023 were considered. The researchers identified and evaluated energy accounting, material flow accounting, water management accounting, carbon management accounting and biodiversity management accounting as effective EMAPs to address local governments’ environmental and service delivery challenges. Furthermore, a conceptual framework to integrate EMAPs with environmental improvement and service delivery plans was developed and has implications for policymakers, communities, government and environmental specialists. The lessons learned from the research are pertinent to developing sustainable cities in emerging economies and further expose the need for further research to consider accounting approaches from higher-income countries as benchmarks for future development of ecosystem accounting to assist local governments in managing environmental challenges.
Investigation of the effects of kiln roller waste addition on porcelain tile matte-opaque glazes
Authors: Oytac Zehra Emel , Tarhan Muge , Yay Busra 
Published: January 2024

AbstractCeramic tiles reach their final microstructures and acquire their technical properties by firing process after shaping, glazing, and drying processes. The firing process is carried out continuously in roller kilns. In roller kilns, tiles pass through firing zones at different firing temperatures such as preheating, firing, and cooling zones in which different types of rollers are used. deformations such as breakage and deterioration of roller smoothness occur in the kiln roller over time due to high temperature and tile mass. For these reasons, unused kiln rollers are separated into waste and replaced with new ones. In the present study, the purpose was to transform the kiln roller into a value-added product. For this purpose, the use of kiln roller wastes in glazed porcelain tile matte-opaque glaze was investigated. Ground kiln roller waste was used instead of alumina, quartz, and zircon in a standard matte-opaque glaze composition. The developed glazes were sintered at 1190 °C for 44 min. The thermal, optical, and physical properties of the glazes were examined and compared with the standard glaze recipe. The melting behaviors of the glazes were measured with a heating microscope, and the thermal expansion coefficients were measured with a dilatometer. The phases developed in the structure were determined by XRD analysis and scanning electron microscope (SEM). According to the results, the usage of roller waste instead of alumina and quartz decreased the crystal phase development in the glaze and the opacity, causing an increase in surface glossiness. When it was used instead of zircon, anorthite and crystal phase development increased and the surface brightness decreased, but the opacity decreased significantly due to the decline of zircon crystals. Considering all these thermal and optical properties, it was determined that the use of roller waste would be possible with some optimizations in the composition of matte-opaque glaze composition.
Achieving the 1.5 °C goal with equitable mitigation in Latin American countries
Authors: Ramírez-Padilla Cindy , Turon Albert , Retamal Cristián , Alcaraz Olga , Sureda Bàrbara 
Published: January 2024

AbstractDuring the past years, the impact of climate change in Latin America has become more evident. It is affecting its natural resources and delaying sustainable development. Achieving the 1.5 °C long-term temperature goal of the Paris Agreement while ensuring the right to sustainable development is of particular interest to regions with high vulnerability and low adaptation capacity for climate change, such as Latin America. This article analyzes whether the Nationally Determined Contributions (NDCs) submitted within the Paris Agreement framework by Latin American countries align with achieving the 1.5 °C goal. For this analysis, the global carbon budget from 2020 onwards, compatible with the 1.5 °C global temperature scenario, is distributed among countries using two dimensions of equity (equality and historical responsibility). Then, the carbon budget allocated to Latin American countries is compared with the cumulative emissions implied in two scenarios. The first one is the NDC scenario that assumes the implementation of the NDCs submitted until December 31, 2022. The second scenario adds the goal of ending deforestation by 2030, signed by several countries of this region in the Global Leaders Declaration on Forest. Two main conclusions are obtained from the analysis of the cited scenarios. First, Latin American countries will consume 77% of their carbon budget in 2030 by implementing their NDCs. Second, this percentage could be reduced to 58% if Latin American countries reach zero emissions from the Land Use, Land Use Change, and Forestry sector by 2030. If achieved, the region would be on track to reach the 1.5 °C global goal.
Pricing levered warrants under the CEV diffusion model
Authors: Glória Carlos Miguel , Dias José Carlos , Cruz Aricson 
Published: January 2024

AbstractMuch of the work on the valuation of levered (and unlevered) warrants assumes that the volatility of the underlying state variable is constant. This paper extends the literature on warrant pricing to a more general assumption for the state variable process, the so-called constant elasticity of variance (CEV) process. The CEV model is well-known for its ability to capture some empirical observations found in the financial economics literature, namely the asymmetry between equity returns and volatility and the implied volatility skew. Using the CEV process, we are able to reduce pricing bias as the volatility becomes a function of the underlying state variable. We price European-style call warrants without restrictions on the debt maturity. When warrants have the same maturity as debt, it is possible to obtain closed-form solutions for warrants prices. When the maturity of warrants is different from the maturity of debt, prices can be computed numerically through very efficient and simple to implement valuation methodologies.
Identification of End-Binding 1 Protein as Novel α-4 Giardin-Binding Partners in Giardia lamblia Trophozoites
Authors: Zhang Kaiyue , Shen Hai’e , Wang Yi , Shen Hailin , Zhang Chenshuo , Zou Xu , Yu Yuan , Tian Xifeng , Wang Yang 
Published: January 2024

Abstract
Background
Giardia lamblia (syn. G. intestinalis, G. duodenalis) is a primitive opportunistic protozoon, and one of the earliest differentiated eukaryotes. Despite its primitive nature, G. lamblia has a sophisticated cytoskeleton system, which is closely related to its proliferation and pathogenicity. Meanwhile, α giardin is a G. lamblia-specific cytoskeleton protein, which belongs to the annexin superfamily. Interestingly, G. lamblia has 21 annexin-like α giardins, i.e., more than higher eukaryotes. The functional differences among α giardin members are not fully understood.

Methods
We took α-4 giardin, a member of α giardin family, as a research object. A morpholino-mediated knockdown experiment was performed to identify the effect of α-4 giardin on G. lamblia trophozoites biological traits. A yeast two-hybrid cDNA library of G. lamblia strain C2 trophozoites was screened for interaction partners of α-4 giardin. Co-immunoprecipitation and fluorescent colocalization confirmed the relationship between G. lamblia EB1 (gEB1) and α-4 giardin.

Results
α-4 Giardin could inhibit the proliferation and adhesion of G. lamblia trophozoites. In addition, it interacted with G. lamblia EB1 (gEB1).

Conclusions
α-4 Giardin was involved in proliferation and adhesion in G. lamblia trophozoites, and EB1, a crucial roles in mitosis, was an interacting partner of α-4 giardin.