bluuebunny/crossref_metadata_2025_split huggingface dataset:
Cardiac stereotactic radiation therapy for refractory ventricular arrhythmias in patients with left ventricular assist devices
Authors: Benali Karim , Lloyd Michael S. , Petrosyan Andranik , Rigal Louis , Quivrin Magali , Bessieres Igor , Vlachos Konstantinos , Hammache Nefissa , Bellec Julien , Simon Antoine , Laurent Gabriel , Higgins Kristin , Garnier Fabien , de Crevoisier Renaud , Martins Raphaël , Da Costa Antoine , Guenancia Charles 
Published: November 2023

AbstractLeft ventricular assist device (LVAD) implantation is an established treatment for patients with advanced heart failure refractory to medical therapy. However, the incidence of ventricular arrhythmias (VAs) is high in this population, both in the acute and delayed phases after implantation. About one‐third of patients implanted with an LVAD will experience sustained VAs, predisposing these patients to worse outcomes and complicating patient management. The combination of pre‐existing myocardial substrate and complex electrical remodeling after LVAD implantation account for the high incidence of VAs observed in this population. LVAD patients presenting VAs refractory to antiarrhythmic therapy and catheter ablation procedures are not rare. In such patients, treatment options are extremely limited. Stereotactic body radiation therapy (SBRT) is a technique that delivers precise and high doses of radiation to highly defined targets, reducing exposure to adjacent normal tissue. Cardiac SBRT has recently emerged as a promising alternative with a growing number of case series reporting the effectiveness of the technique in reducing the VA burden in patients with arrhythmias refractory to conventional therapies. The safety profile of cardiac SBRT also appears favorable, even though the current clinical experience remains limited. The use of cardiac SBRT for the treatment of refractory VAs in patients implanted with an LVAD are even more scarce. This review summarizes the clinical experience of cardiac SBRT in LVAD patients and describes technical considerations related to the implementation of the SBRT procedure in the presence of an LVAD.
Effects of physical activity on the levels of remnant cholesterol: A population‐based study
Authors: Chen Jingfei , Luo Qin , Su Yingjie , Wang Jiangang , Fang Zhenfei , Luo Fei 
Published: November 2023

AbstractPhysical activity (PA) has the potential to bring about favourable changes in plasma lipid profile. However, the relationship between PA and remnant cholesterol (RC) remains unclear. We aimed to study the link between PA and RC using the database of the 2007–2020 National Health and Nutrition Examination Survey (NHANES). PA was categorized based on Physical Activity Guidelines for Americans. A multivariate linear regression model was used to determine the correlations between PA and RC. The study involved a total of 18,396 participants and revealed that individuals whose PA met the guidelines by engaging in moderate‐intensity PA at least 150 min per week had lower body mass index and showed decreased levels of triglyceride, TC, and haemoglobin A1c compared to those who were physically inactive, exercising <150 min per week. Participants whose intensity of PA meets PA guidelines had a lower level of RC than those who did not met PA guidelines (β = −1.3, 95% confidence interval [CI]: −1.9 to −0.7, p < 0.001), even after adjusting for confounders. During subgroup analysis, we observed that race (pinteraction = 0.0089) emerged as a significant factor of interaction.
Considerations for predictable outcomes in static computer‐ aided implant surgery in the esthetic zone
Authors: Markovic Jovana , Peña‐Cardelles Juan Francisco , Pedrinaci Ignacio , Hamilton Adam , Gallucci German O. , Lanis Alejandro 
Published: November 2023

AbstractObjectiveTo provide technical and clinical recommendations for implementing a digital workflow in Static Computer‐Aided Implant Surgery in the anterior maxilla.Clinical ConsiderationsAn optimal 3D implant position is crucial for achieving satisfying results in implant rehabilitation in the esthetic area. Due to its complexity, implant placement in the esthetic zone should be executed with precision and predictability. Static Computer‐Aided Implant Surgery requires thorough planning and detailed attention to every step of the digital workflow protocol.ConclusionsImplant positioning in the esthetic zone using Static Computer‐Aided Implant Surgery is a technique‐sensitive procedure that requires precise execution of each step. This approach ensures accurate prosthetically driven 3D implant placement and prevents potential errors that could lead to inaccurate positioning.Clinical SignificanceThe proper implementation of Static Computer‐Aided Implant Surgery may increase the level of agreement between the planned and definitive implant 3D positions in the esthetic zone, thus enhancing the esthetic outcomes of implant rehabilitation.
Taxonomic revision of Sturisoma Swainson, 1838 (Loricariidae: Loricariinae), with descriptions of four new species
Authors: Londoño‐Burbano Alejandro , Britto Marcelo R. 
Published: November 2023

AbstractA taxonomic revision of Sturisoma is presented. Individuals including both type and non‐type specimens of all valid species were examined. Sturisoma was found to comprise 10 valid species: Sturisoma barbatum, Sturisoma brevirostre, Sturisoma graffini, Sturisoma guentheri, Sturisoma lyra, Sturisoma monopelte, Sturisoma nigrirostrum, Sturisoma reisi, Sturisoma rostratum, and Sturisoma tenuirostre. Furthermore, four new species are described: Sturisoma ghazziae, new species, from the Araguaia River, belonging to the Tocantins‐Araguaia basin, Central Brazil; Sturisoma careirensia, new species, from the middle Amazon basin, Brazil; Sturisoma rapppydanielae, new species, from the Purus River, Amazon basin, Brazil; and Sturisoma defranciscoi, new species, from the Putumayo and Solimões rivers, upper Amazon basin, Colombia, and Brazil. Sturisoma robustum is confirmed as synonym of S. barbatum, species registered along the Paraguay/Parana/La Plata River basin in Argentina, Brazil, and Paraguay. New records were found for S. nigrirostrum as present in the upper Amazon basin, in the Yavari River, Brazil, in addition to its already known locality, the Ucayali River, Peru. The distribution of the type species of the genus S. rostratum is limited to the lower portion of the Amazon basin in the Araguaia, Maranhão, Mearim, Tapajós, and Tocantins rivers and its affluents, Brazil, in contrast to the assumed widespread distribution across the main basins of South America, as previously proposed for the species; the Mearim River is a new record for the species. Updated diagnoses and descriptions are offered for species of Sturisoma, in addition to distribution maps and an identification key for the species.
Numerical analysis of charge characteristics of electrostatic chute for edible powder
Authors: Zhang Dongkai , Xu Xuemeng , Tang Jingjing , Jia Changxue , Lv Junzhi 
Published: November 2023

AbstractThe influence of physical parameters on the charge characteristics of food powder in the process of electrostatic chute transportation was studied to provide technical support for the electrostatic elimination of food powder in the process of conveying and packaging. Taking edible powder as the research object, firstly, the particle model was established, and the three‐dimensional model of electrostatic chute was imported into EDEM software to calibrate the parameters of particles with different particle size distribution, different water content and different chute materials. Then the chute transport simulation was carried out on the calibrated edible powder to analyze the variation law of the average charge‐mass ratio of the powder. The electrostatic chute test platform was built to complete the relevant tests. The simulation study found that the average charge‐mass ratio between wheat flour with water content of 10%, 12%, 14%, 16%, and 18% and 304 stainless steel chute is 7.024, 7.01, 6.838, 6.55, and 5.932 nC/g, respectively. The average charge‐mass ratio in contact with PVC chute is 5.622, 4.808, 4.766, 4.412, and 4.768 nC/g; The average charge‐mass ratio between wheat starch with the same moisture content and 304 stainless steel chute is 2.984, 2.468, 2.254, 2.248, and 2.078 nC/g, and the average charge‐mass ratio between wheat starch and PVC chute is 2.522, 2.152, 1.962, 1.371, and 2.026 nC/g. When the water content is the same (10%–18%), the static friction Angle of powder and chute is negatively related to the charge of wheat flour and wheat starch in the static chute. The higher the water content of wheat flour and wheat starch (10%–16%), the worse the chargability. The charge characteristics of wheat flour with large grain size distribution range are higher than those of wheat starch with small grain size distribution range. The results of electrostatic chute test and simulation are consistent, which verifies the correctness of the simulation results. The research results provide certain reference for the electrostatic elimination in the process of food powder conveying and packaging.Practical ApplicationIn this paper, EDEM is used to establish the particle parameter model of food powder, and the parameters of wheat starch and wheat flour particles are calibrated through the combination of experiment and simulation, and electrostatic chain‐simulation experiments are carried out. By obtaining the average charge‐mass ratio change of powder's charge characteristics under different influencing factors, the corresponding electrostatic influence rule of powder is found. The influence of physical property parameters on the charge characteristics of food powder in the process of electrostatic chute transportation was studied to provide technical support for electrostatic elimination in the process of food powder transportation and packaging.
Knockout of a rice K5.2 gene increases Ca accumulation in the grain
Authors: Wang Peitong , Yamaji Naoki , Mitani‐Ueno Namiki , Ge Jun , Ma Jian Feng 
Published: November 2023

ABSTRACTRice is a staple food for half of the world's population, but it is a poor dietary source of calcium (Ca) due to the low concentration. It is an important issue to boost Ca concentration in this grain to improve Ca deficiency risk, but the mechanisms underlying Ca accumulation are poorly understood. Here, we obtained a rice (Oryza sativa) mutant with high shoot Ca accumulation. The mutant exhibited 26%–53% higher Ca in shoots than did wild‐type rice (WT) at different Ca supplies. Ca concentration in the xylem sap was 36% higher in the mutant than in the WT. There was no difference in agronomic traits between the WT and mutant, but the mutant showed 25% higher Ca in the polished grain compared with the WT. Map‐based cloning combined with a complementation test revealed that the mutant phenotype was caused by an 18‐bp deletion of a gene, OsK5.2, belonging to the Shaker‐like K+ channel family. OsK5.2 was highly expressed in the mature region of the roots and its expression in the roots was not affected by Ca levels, but upregulated by low K. Immunostaining showed that OsK5.2 was mainly expressed in the pericycle of the roots. Taken together, our results revealed a novel role for OsK5.2 in Ca translocation in rice, and will be a good target for Ca biofortification in rice.
Can Repatriation Tax Holidays Teach Us Something About Monetary Policy Transmission?
Authors: ARGUDO ESTEBAN 
Published: November 2023

AbstractI study the “bank lending channel” using the 2004 repatriation tax holiday as a natural experiment. I isolate the effect of the repatriated funds on loan supply by (i) comparing the differences in lending between multinational and domestic banks pre‐ and postrepatriation and (ii) using the change in cash holdings abroad as an instrument for the repatriated funds. My results support the existence of the “bank lending channel.” I document that each additional repatriated dollar led to an increase of $0.04 in lending, which is driven entirely by commercial and industrial loans.
Cross‐species single‐cell landscape of vertebrate pineal gland
Authors: Zheng Jihong , Song Wenqi , Zhou Yihang , Li Xuan , Wang Meng , Zhang Chao 
Published: November 2023

AbstractThe pineal gland has evolved from a photoreceptive organ in fish to a neuroendocrine organ in mammals. This study integrated multiple daytime single‐cell RNA‐seq datasets from the pineal glands of zebrafish, rats, and monkeys, providing a detailed examination of the evolutionary transition at single‐cell resolution. We identified key factors responsible for the anatomical and functional transformation of the pineal gland. We retrieved and integrated daytime single‐cell transcriptomic datasets from the pineal glands of zebrafish, rats, and monkeys, resulting in a total of 22 431 cells after rigorous quality filtering. Comparative analysis was then conducted to elucidate the evolution of pineal cells, their photosensitivity, their role in melatonin production, and the signaling processes within the glands of these species. Our analysis identified distinct cellular compositions of the pineal gland in zebrafish, rats, and monkeys. Zebrafish photoreceptors exhibited comprehensive phototransduction gene expression, while specific genes, including transducin (Gngt1, Gnb3, and Gngt2) and phosducin (Pdc), were consistently present in mammalian pinealocytes. We found transcriptional similarities between the pineal gland and retina, underscoring shared evolutionary and functional pathways. Zebrafish displayed unique light‐responsive circadian gene activity compared to rats and monkeys. Key ligand‐receptor interactions were identified, especially involving MDK and PTN, influencing melatonin synthesis across species. Furthermore, we observed species‐specific GPCR (G protein‐coupled receptors) expressions related to melatonin synthesis and their alignment with retinal expressions. Our findings also highlighted specific transcription factors (TFs) and regulatory networks associated with pineal gland evolution and function. Our study provides a detailed analysis of the pineal gland's evolution from fish to mammals. We identified key transcriptional changes and controls that highlight the gland's functional diversity. Notably, we found significant ligand‐receptor interactions influencing melatonin synthesis and demonstrated parallels between pineal and retinal expressions. These insights enhance our understanding of the pineal gland's role in phototransduction, melatonin production, and circadian rhythms in vertebrates.
A novel RT‐qPCR health assay reveals differential expression of stress and immunoregulatory genes between the seasonal migrations of humpback whales (Megaptera novaeangliae)
Authors: Linsky Jacob M. J. , Dunlop Rebecca A. , McMichael Lee A. 
Published: November 2023

AbstractHealth information is essential for the conservation management of whale species. However, assessing the health of free‐ranging whales is challenging as samples are primarily limited to skin and blubber tissue. Reverse transcription quantitative polymerase chain reaction (RT‐qPCR) offers a method to measure health from blubber RNA, providing insights into energetic status, stress and immune activity. To identify changes in health, natural differences in baseline gene expression linked to an individual's sex, reproductive status and life‐history stage must first be quantified. This study aimed to establish baseline gene expression indices of health in migrating humpback whales (Megaptera novaeangliae). To do this, we developed an assay to quantify seven health‐related gene transcripts (Leptin, Leptin Receptor, Adiponectin, Aryl Hydrocarbon Receptor, Tumour Necrosis Factor‐α, Interleukin‐6, Heat Shock Protein‐70) and used Bayesian mixed effect models to assess differential baseline expression based on sex, lactation status and migration stage (northbound to and southbound from the annual breeding grounds). Results showed no significant contribution of sex to differential baseline expression. However, lactating individuals exhibited downregulated AhR and HSP‐70 compared to non‐lactating conspecifics. Additionally, southbound individuals demonstrated significantly upregulated HSP‐70 and downregulated TNF‐alpha, suggesting a relationship between these inflammation‐linked transcripts and migratory fasting. Our results suggest that baseline differences due to migratory stage and lactation status should be considered in health applications of this assay. Future monitoring efforts can use our baseline measurements to better understand how gene expression is tied to population‐level impacts, such as reduced prey availability or migratory stressors.
Capillary malformations in a child caused by a novel HRAS mutation
Authors: van Gysel Dirk , de Maeseneer Hannelore , Legius Eric , Brems Hilde 
Published: November 2023

AbstractA 6‐year‐old boy with multiple capillary malformations of the port‐wine birthmark (PWB) type on the right leg since birth presented with a varicose vein and segmental overgrowth of the affected leg. Genetic testing on affected skin confirmed the presence of a somatic novel pathogenic HRAS 30 bp in‐frame duplication/insertion in the switch II domain. This case illustrates the phenotypic overlap of different genotypes and shows that somatic HRAS pathogenic variants, especially in‐frame duplications/insertions, must be added to the list of the underlying causes in capillary malformations.
Mobile cone‐beam computed tomography complementing shape‐sensing robotic‐assisted bronchoscopy in the small pulmonary nodule sampling: A multicentre experience
Authors: Abia‐Trujillo David , Folch Erik E. , Yu Lee‐Mateus Alejandra , Balasubramanian Prasanth , Kheir Fayez , Keyes Colleen M. , Villalobos Regina , Chadha Ryan M. , Hazelett Britney N. , Fernandez‐Bussy Sebastian 
Published: November 2023

AbstractBackground and ObjectiveShape‐sensing robotic‐assisted bronchoscopy (ssRAB) has expanded as an important diagnostic tool for peripheral pulmonary nodules (PPNs), with diagnostic yields ranging from 60% to 88%. However, sampling and diagnosing PPN less than 2 cm in size has historically been challenging. Mobile cone‐beam computed tomography (mCBCT) has been recently integrated into ssRAB to improve diagnostic accuracy, but its added value remains uncertain. We aim to describe the role of mCBCT and determine if it provides any diagnostic advantage.MethodsA multicentre, retrospective study on the use of ssRAB and mCBCT in two tertiary care institutions: Mayo Clinic Florida and Massachusetts General Hospital. The primary outcome was diagnostic yield and sensitivity for malignancy of ssRAB complemented with mCBCT, compared to ssRAB with the standard 2D fluoroscopy.ResultsA total of 192 nodules were biopsied from 173 patients. mCBCT was used in 117 (60.9%) nodules. The overall diagnostic yield was 85.4%. Diagnostic yield between subgroups with and without mCBCT was 83.8% and 88% (p = 0.417), respectively. The mCBCT group had fewer solid nodules (65.8% vs. 81.3%, p = 0.020) and a higher number of ground‐glass nodules (10.3% vs. 1.3%, p = 0.016).ConclusionOverall, diagnostic yield between subgroups with and without mCBCT was similar. The complementary use of mCBCT to ssRAB allows proceduralists to target more complex and subsolid PPNs with a diagnostic yield comparable to simple solid PPNs while maintaining an excellent safety profile.
‘Send the midwife’: The Birth of Blackness in Titus Andronicus
Authors: Bui Hanh 
Published: November 2023

AbstractThis article examines a neglected context for understanding the ontology and epistemology of race in Shakespeare's drama: the role of the midwife. Early modern midwives performed an important cultural function by not only assisting women in labour, but also pronouncing the sex and paternity of a newborn. As Caroline Bicks has shown, this was a time when a midwife was thought to have significant influence over how a body was literally shaped and interpreted at the moment of its birth, thereby determining its reception in the community. Nowhere in Shakespeare's canon is the midwife's authority more manifest – and threatening – than in Titus Andronicus, where the midwife's role includes establishing an infant's race. After Tamora, Empress of Rome, delivers a baby fathered by her lover, Aaron ‘the Moor’, he asks: ‘How many saw the child?’ By subsequently killing the birth attendants, Aaron calls attention to how controlling the destiny of his son will depend upon rewriting the script of his nativity. Merging critical interest in early modern childbirth with Shakespeare scholarship on race and performance, I show how newly born bodies are midwived into racialized subjects, illuminating how midwifery discourses can broaden our understanding of early modern racecraft. My specific claim is that the statements made by Tamora's nurse concerning Aaron's ‘black’ son can be read as a performative utterance that confers, constitutes and attempts to naturalize the newborn's raced identity.
Overcoming unintended consequences of social impact accountability: How to avoid counterproductive responses of individuals and groups in organizations
Authors: Ellemers Naomi , de Gilder Dick 
Published: November 2023

AbstractThis contribution aims to explain when and why policies that increase social accountability are likely to have unintended and counterproductive effects on the social performance of organizations. The Behavioral Regulation Model applies insights from social identity theory to recent research on moral psychology. This elucidates that deep concerns about social approval for one's morality and good intentions, raise “the paradox of morality”: The motivation to signal endorsement of social values and good intentions prompts people to justify and defend shortcomings in these domains, instead of addressing them. We demonstrate how this approach and research supporting it can help recognize and understand a range of defensive responses organizations and their representatives are likely to show. Subsequently, we specify how policymakers, regulators, and other stakeholders can circumvent these counterproductive effects and help people in organizations to show more constructive responses toward social impact improvement.
Some pedagogical elements of computer programming for data science: A comparison of three approaches to teaching the R language
Authors: Shilane David , Di Crecchio Nicole , Lorenzetti Nicole L. 
Published: November 2023

AbstractEducational curricula in data analysis are increasingly fundamental to statistics, data science, and a wide range of disciplines. The educational literature comparing coding syntaxes for instruction in data analysis recommends utilizing a simple syntax for introductory coursework. However, there is limited prior work to assess the pedagogical elements of coding syntaxes. The study investigates the paradigms of the dplyr, data.table, and DTwrappers packages for R programming from a pedagogical perspective. We enumerate the pedagogical elements of computer programming that are inherent to utilizing each package, including the functions, operators, general knowledge, and specialized knowledge. The merits of each package are also considered in concert with other pedagogical goals, such as computational efficiency and extensions to future coursework. The pedagogical considerations of this study can help instructors make informed choices about their curriculum and how best to teach their selected methods.