bluuebunny/crossref_metadata_2025_split huggingface dataset:
Bunium persicum Seeds Extract in Combination with Vincristine Mediates Apoptosis
in MCF-7 Cells through Regulation of Involved Genes and Proteins Expression
Authors: Samandari-Bahraseman Mohammad Rasoul , Ismaili Ahmad , Esmaeili-Mahani Saeed , Ebrahimie Esmaeil , Loit Evelin 
Published: December 2023

Background::
Bunium persicum seeds, a member of the Apiaceae family, have historically been consumed
as part of the Iranian diet.

Objective::
While many of this herb's biological properties have been fully investigated, there is currently no
reliable information about its anticancer/cytotoxic properties.

Methods::
Herein, we first determined the major bioactive compounds of B. persicum seed extract (BPSE) via
GC-Mass analysis. We evaluated the cytotoxicity of the extract alone as well as in combination with vincristine
(VCR), a commonly used chemotherapy drug, using MTT assays on two breast cancer cell lines, MCF-7 and
MDA-MB-231, as well as a normal breast cancer cell line, MCF-10A. Moreover, these compounds were evaluated
in vitro for their anticancer activity using ROS assays, Real-Time PCR, Western blots, flow cytometry, and
cell cycle assays.

Results::
As a result of our investigation, it was determined that the extract significantly reduced the viability of
cancerous cells while remaining harmless to normal cells. The combination of BPSE and VCR also resulted in
synergistic effects. BPSE and/or BPSE-VCR treatment increased the intracellular ROS of MCF-7 cells by over
twofold. Moreover, the IC30 of BPSE (100 μg/ml) significantly increased the BAX/BCL-2 and P53 gene expression
while reducing the expression of the MYC gene. Moreover, treated cells were arrested in the G2 phase of the
cell cycle. The BPSE-VCR combination synergistically reduced the NF-κB and increased the Caspase-7 proteins’
expression. The percent of apoptosis in the cells treated with the extract, VCR, and their combination was 27, 11,
and 50, respectively.

Conclusions::
The present study demonstrated the anticancer activity of the BPSE and its potential for application
in combination therapy with VCR.
Anti-inflammatory Effects of Compounds Extracted from Marine Sponge s:
A Systematic Review
Authors: Magri Angela Maria Paiva , Avanzi Ingrid Regina , Vila Guilherme Trindade , Granito Renata Neves , Estadella Débora , Jimenez Paula Christine , Ribeiro Alessandra Mussi , Rennó Ana Claudia Muniz 
Published: December 2023

Background:
Previous studies have experimentally validated and reported that chem-ical constituents of marine sponges are a source of natural anti-inflammatory substances with the biotechnological potential to develop novel drugs.

Aims:
Therefore, the aim of this study was to perform a systematic review to provide an overview of the anti-inflammatory substances isolated from marine sponges with therapeutic potential.

Methods:
This systematic review was performed on the Embase, PubMed, Scopus and Web of Science electronic databases. In total, 613 were found, but 340 duplicate studies were excluded, only 100 manuscripts were eligible, and 83 were included.

Results:
The results were based on in vivo and in vitro assays, and the anti-inflammatory effects of 251 bioactive compounds extracted from marine sponges were investigated. Their anti-inflam-matory activities include inhibition of pro-inflammatory mediators, such as tumor necrosis factor-α (TNF-α), interleukin-6 (IL-6), nitrite or nitric oxide (NO), inducible nitric oxide synthase (iNOS), cyclooxygenase-2 (COX-2), interleukin 1β (IL-1β), prostaglandin E2 (PGE2), phospho-lipase A2 (PLA2), nuclear transcription factor-kappa B (NF-κB), leukotriene B4 (LTB4), cy-clooxygenase-1 (COX-1), and superoxide radicals.

Conclusion:
In conclusion, data suggest (approximately 98% of articles) that substances obtained from marine sponges may be promising for the development of novel anti-inflammatory drugs for the treatment of different pathological conditions.
Knowledge Representation of Sensor Dataset with IoT Collaboration of Semantic Web and IoT: Storage of Temperature and Humidity Details
Authors: Mori Gajendrasinh N. , Swaminarayan Priya R. , Panchal Ronak 
Published: December 2023

Introduction:
Today, Internet of Things applications offer new opportunities in all domains
like home automation, transportation, medical diagnosis, agriculture, etc. According to
McKinsey Global Institute research, IoT will cover a market share of over $11.1 trillion by 2025.
Moreover, Semantic web technology approaches are used in IoT applications so that machines
can understand and interpret sensor-collected data.

Method:
Our proposed system uses a DHT11
sensor, NodeMCU for data collection, and ThingSpeak cloud for data analysis and visualization.
It utilizes the Protégé tool to develop semantic data modelling using Ontology/RDF graphs and
retrieval for future SPARQL queries.

Result:
This approach ensures the optimal presentation of
sensor data and the meaning of data and controls the information for the Home Automation System.
By semantic layer, we improved integration, interoperability, discovery, and data analysis.

Conclusion:
As far as applications are concerned, semantic technologies and IoT sensor data can
be transformed into a more valuable and practical format, enabling intelligent applications and
systems development across multiple fields, such as smart cities, industrial automation,
healthcare, and environmental monitoring.
Metal Organic Frameworks: Synthesis, Characterization and Drug
Delivery Applications
Authors: Mhettar Prachi , Patil Rasika , Patil Dipti , Pantwalawalkar Jidnyasa , Jadhav Namdeo 
Published: December 2023

Abstract:
Since the last few years, metal organic frameworks (MOFs) have been attracting attention
from scientific sororities. MOFs are novel porous materials with robust architectures that demonstrate
a multitude of applications in theranostics. Interestingly, it shows adaptable porosity, versatile
chemical configuration, tunable size and shape, tailorable surface functionalization, etc. MOFs have
a very porous network space that makes it possible to efficiently pack drug payloads and different
imaging markers. Nano-MOFs (NMOFs) are additionally biodegradable in nature due to the metalligand
linkages and their greater labile-ness. The present review article provides insights into the
fabrication of MOFs, especially different synthesis methodologies, along with merits and limitations.
A thorough description of several characterization techniques of MOFs and underlying principles
have also been depicted. Moreover, the role of MOFs as a promising nanocarrier for small molecules/
active pharmaceutical ingredients (APIs) and biomolecule delivery has been deliberated along
with their theranostic potential. In a nutshell, this review offers the most recent advancements in
NMOFs for use in drug delivery applications. In line with this, MOF stands out as a versatile carriers
compared to other nanomaterials due to the multitude of uses it has in drug delivery and theragnostic,
emanating high hopes for its future clinical application.
Asymmetric Flared Vivaldi MIMO Antenna for 5G Millimeter Wave Communication
Authors: Paliwal Harsh Prabha , Agrawal Navneet , Chouhan Dungar Nath , Jhajharia Tejpal 
Published: December 2023

Background::
As a panacea for most of today's wireless communication problems, recently,
the evolution and demand for mm-wave devices and antennas are increasing for their use
in different applications and future millimeter wave communication. A 4-port miniaturized
Asymmetric Vivaldi MIMO (Multiple Input Multiple Output) antenna is designed and presented
for millimeter wave communication.

Method and Meterial::
The top side is made up a flared shape patch with an oval shape structure,
while the back side is made up of partial ground with flare shaped structure to achieve minimum
mutual coupling. The Vivaldi structure is used on a low-cost FR4 dielectric substrate for
wide bandwidth and high gain with a loss tangent of 0.02. The designed MIMO has an overall size
of 31 x 40 mm2. The proposed MIMO covers a 20-40 GHz dual frequency band.

Result::
The achieved isolation between antenna elements is more than 53.40 dBi, which shows
the low mutual coupling between antenna elements. The simulated response for the proposed antenna
is reported in terms of gain, ECC, surface current distribution, VSWR, returns loss, and directivity
and shows the MIMO antenna’s good performance characteristics.

Conclusion::
Both the simulated and measured results are presented, and it shows good agreement
between them.
Numerical Investigation on Effect of Bubbles Arrangement and
Volume Fraction on Apparent Viscosity of Bubbly Suspensions
Authors: Jia Zheng , Pang Mingjun , Niu Ruipeng 
Published: December 2023

Background::
Bubbly suspensions can be often run into in natural and industrial processes.
The addition of bubbles with different sizes can lead to a significant change in the rheological
properties of a matrix liquid. It is extremely significant to fully understand the rheological
properties of bubbly suspensions for improving process efficiencies and optimizing productive
processes.

background:
Bubbly suspensions can be often run into in natural and industrial processes. The addition of bubbles of different sizes can greatly change the rheological properties of matrix liquid. It is extremely significant to fully understand the rheological properties of bubbly suspensions for improving process efficiencies and optimizing productive processes.

Objective::
The objective of this study is to explore qualitatively the physical law and internal
mechanism of the apparent viscosity of suspensions formed by a Newtonian liquid containing
different bubbles.

Methods::
Based on the parallel plate model of shear flow, the volume of fluid method (VOF)
was used to investigate the effect of bubble arrangement and volume fraction on the apparent
viscosity of bubbly suspensions at low volume fractions. The piecewise linear interface calculation
(PLIC) method was applied to reconstruct the interface based on the phase function.

Results::
The present results show that the relative viscosity (ηr) of bubbly suspensions shows a
nonlinear change with an increase in bubble volume fraction (ϕ). When the capillary number
(Ca) is less than 0.6, ηr shows a nonlinear increase with an increase in ϕ (ηr increases from 1 to
1.03 with an increase in ϕ from 0 to 2.94% at Ca=0.1). However, Ca is greater than or equal to
0.6, ηr shows a nonlinear decrease with an increase in ϕ (ηr decreases from 1 to 0.92 with an
increase in ϕ from 0 to 2.94% at Ca=2.5). Even if ϕ is the same, different arrangements of bubbles
can lead to different magnitudes of apparent viscosity of bubbly suspensions

Conclusion::
As ϕ increases, the region of low shear rate increases, which leads to a non−linear
decrease in the relative viscosity. When ϕ is the same, the different arrangements of bubbles can
lead to different effects on bubble dynamics and flow fields. This results in different viscous
dissipation in bubbly suspensions. Thus, the apparent viscosity of bubbly suspensions is different.

other:
Nothing
Older Adults’ Perceptions About Using Intelligent Toilet Seats Beyond Traditional Care: Web-Based Interview Survey
Authors: Esmaeilzadeh Pouyan 
Published: December 2023

Background
In contemporary society, age tech (age technology) represents a significant advancement in health care aimed at enhancing patient engagement, ensuring sustained independence, and promoting quality of life for older people. One innovative form of age tech is the intelligent toilet seat, which is designed to collect, analyze, and provide insights based on toileting logs and excreta data. Understanding how older people perceive and interact with such technology can offer invaluable insights to researchers, technology developers, and vendors.

Objective
This study examined older adults’ perspectives regarding the use of intelligent toilet seats. Through a qualitative methodology, this research aims to unearth the nuances of older people’s opinions, shedding light on their preferences, concerns, and potential barriers to adoption.

Methods
Data were collected using a web-based interview survey distributed on Amazon Mechanical Turk. The analyzed data set comprised 174 US-based individuals aged ≥65 years who voluntarily participated in this study. The qualitative data were carefully analyzed using NVivo (Lumivero) based on detailed content analysis, ensuring that emerging themes were coded and classified based on the conceptual similarities in the respondents’ narratives.

Results
The analysis revealed 5 dominant themes encompassing the opinions of aging adults. The perceived benefits and advantages of using the intelligent toilet seat were grouped into 3 primary themes: health-related benefits including the potential for early disease detection, continuous health monitoring, and seamless connection to health care insights. Technology-related advantages include the noninvasive nature of smart toilet seats and leveraging unique and innovative data collection and analysis technology. Use-related benefits include ease of use, potential for multiple users, and cost reduction owing to the reduced need for frequent clinical visits. Conversely, the concerns and perceived risks were classified into 2 significant themes: psychological concerns, which included concerns about embarrassment and aging-related stereotypes, and the potential emotional impact of constant health monitoring. Technical performance risks include concerns centered on privacy and security, device reliability, data accuracy, potential malfunctions, and the implications of false positives or negatives.

Conclusions
The decision of older adults to incorporate intelligent toilet seats into their daily lives depends on myriad factors. Although the potential health and technological benefits are evident, valid concerns that need to be addressed remain. To foster widespread adoption, it is imperative to enhance the advantages while simultaneously addressing and mitigating the identified risks. This balanced approach will pave the way for a more holistic integration of smart health care devices into the routines of the older population, ensuring that they reap the full benefits of age tech advancements.
Pengaruh Eccentric Exercise terhadap Peningkatan Kemampuan Fungsional pada Kondisi Achilles Tendinopathy: Tinjauan Kritis
Authors: Hidayati Asri Lutfika , Rahman Farid 
Published: December 2023

Latar Belakang: Achilles tendinopathy (AT) merupakan cidera yang sering terjadi dengan prevalensi kejadian pada atlet diperkirakan sebesar 6,2-9,5% dan pada non atlet sebesar 11,83 tiap 100 pasien per hari. Salah satu latihan yang dapat dilakukan setelah mengalami achilles tendinopathy adalah eccentric exercise atau disebut juga the alfredson protocol.Tujuan: Penelitian ini bertujuan untuk mengetahui pengaruh eccentric exercise terhadap peningkatan kemampuan fungsional pada kondisi achilles tendinopathyMetode: Metode ini menggunakan desain critical review dengan mengidentifikasi berdasarkan kata kunci, kemudian melakukan review artikel dengan syarat inklusi artikel menggunakan metode Randomized Controlled Trial (RCT) dan dianalisis menggunakan PICO. Terdapat sepuluh artikel yang didapatkan dari basis pencarian data primer seperti pada Biomedic Database (PubMed), Physiotherapy Evidence Database (PEDro), Science Direct, NCBI, Jane Biosemantics, dan Portal Garuda (Garba Rujukan Digital). Appraisal dilakukan dengan merujuk pada hasil PEDro scale. Review ini menggunakan artikel dengan periode waktu dari 2012‒2022.Hasil: Hasil dari tinjauan sepuluh artikel didapatkan bahwa pada kondisi AT terdapat peningkatan kemampuan fungsional berdasarkan Victorian Institute of Sport Assessment Achilles Tendinopathy Questionnaire (VISA-A) setelah diberikan eccentric exercise.Kesimpulan: Eccentric exercise memiliki pengaruh terhadap peningkatan kemampuan fungsional pada kondisi achilles tendinopathy
Efektivitas Alat Extraoral Suction Unit pada Layanan Kesehatan Gigi dan Mulut
Authors: Prayoga Benidiktus Tulung , Winarno Agustinus , Rinastiti Margareta , Sari Dian Permata , Yulianto Heribertus Dedy Kusuma , Hendrartini Julita 
Published: December 2023

Latar Belakang: Petugas layanan kesehatan gigi dan mulut rentan terpapar infeksi berbagai penyakit dari pasien. Rongga mulut penuh dengan bakteri. Droplets dan aerosol dari cairan mulut pasien dapat menjadi media penularan penyakit. Extraoral suction unit (EOSU) dibutuhkan untuk membantu mengendalikan sebaran aerosol selama layanan kesehatan gigi.Tujuan: Penelitian ini bertujuan untuk membandingkan unjuk kerja extra oral suction unit lokal dengan produk komersial sebagai pembanding.Metode: Desain penelitian ini menggunakan metode deskriptif observasional dengan rancangan cross sectional. Sampel penelitian berupa alat penyedot aerosol hasil rancangan tim peneliti Universitas Gadjah Mada Merk D yang dibandingkan dengan dua produk komersial dari luar negeri Merk A dan B, satu alat produk dalam negeri Merk C. EOSU diuji di klinik gigi dengan prosedur serupa layanan sesungguhnya. Pengujian yang dilakukan adalah mengukur kapasitas hisap, tingkat kebisingan, sebaran aerosol dan angka kuman.Hasil: Extraoral suction unit produk buatan luar negeri (Merk A) menunjukkan unjuk kerja yang paling baik karena sebaran aerosol di sekitar lokasi kerja paling sedikit. Produk Merk D mempunyai unjuk kerja di bawah produk Merk A namun masih lebih baik dibanding produk buatan luar negeri lainnya (Merk B) dan produk dalam negeri lain (Merk C)Kesimpulan: Extraoral suction unit lokal mempunyai kapasitas serupa dengan produk komersial dan menjanjikan untuk diproduksi massal.
Pemetaan Spasial Malaria dan Faktor Risiko di Kecamatan Lamboya Kabupaten Sumba Barat
Authors: Mbiliyora Agustina , Satoto Tri Baskoro Tunggul , Murhandarwati Elsa Herdiana 
Published: December 2023

Latar Belakang: Malaria adalah penyakit tular vektor yang masih menjadi masalah utama kesehatan masyarakat di Kecamatan Lamboya Sumba Barat. Analisis spasial diperlukan untuk mengetahui sebaran kasus malaria, penentuan wilayah receptive dan vulnerable.Tujuan: Penelitian bertujuan untuk mengetahui pola sebaran kasus malaria, tipe habitat jentik, pemetaan wilayah receptive dan vulnerable dan pengaruh faktor risiko di Kecamatan LamboyaMetode: Penelitian ini menggunakan rancangan unmatched case control. Besar sampel masing-masing 36 kontrol responden positif dan negatif malaria Januari 2023. Data diperoleh melalui e-SISMAL (Elektronik Sistem Informasi Surveilans Malaria) Puskesmas Kabukarudi dan Klinik Malaria. Analisis data meliputi analisis spasial dengan QGIS, univariat dan bivariat dengan uji chi-square. Wilayah receptive ditentukan berdasarkan temuan kasus malaria dan habitiat positif jentik, vulnerable wilayah tanpa kasus namun berbatasan langsung dengan wilayah receptiveHasil: Sebaran malaria berpola random dekat habitat nyamuk radius 500m ada 25 kasus dan radius 1000m ada 6 kasus. Habitat positif jentik pada sawah, mata air, muara, sungai, genangan dan kubangan. Lima wilayah receptive pada Patiala Bawa, Palamoko, Lamboya Bawa, Ringurara dan Watukarere. Tiga wilayah vulnerable Wailibo, Kabukarudi dan Rajaka. Hasil identifikasi nyamuk ditemukan An.Vagus, An.Limosus, An.Subpictus, An. Indefinitus dan An.Annularis.Kesimpulan: Pola sebaran malaria menyebar mendekati habitat nyamuk. Ditemukannya nyamuk potensial vektor malaria dan habitat positif jentik menunjukkan bahwa di Kecamatan Lamboya berpotensi tinggi terjadinya penularan malaria.
Pengaturan Pengaktifan Kembali Rekam Medis Elektronik pada Rumah Sakit X Kota Denpasar
Authors: Sri Murcittowati Putu Ayu , Wirajaya Made Karma Maha , Astuti Ika Widi , Kartika I Gusti Ayu , Farmani Putu Ika 
Published: December 2023

LatarBelakang: Pelaksanaan Rekam Medis Elektronik (RME) pada fasilitas pelayanan kesehatan terdapat ketimpangan dengan Permenkes No. 24 Tahun 2022 tentang Rekam Medis (RM). Salah satunya adalah ketimpangan adalah perbaikan atau penambahan catatan RM yang berujung pada pengaktifan kembali RME lebih dari 2x24 jam.Tujuan: Penelitian ini bertujuan untuk mengetahui pengaturan dan hak akses pengaktifan kembali RME.Metode: Desain penelitian ini menggunakan pendekatan kualitatif dengan metode postpositivistik. Sampel penelitian dari Instalasi RM periode April 2023 berjumlah 43 RM yang telah mengalami perbaikan. Pengumpulan data dilakukan dengan wawancara serta teknik triangulasi berupa studi dokumentasi dan observasi.Hasil: Proses pengaktifan kembali meliputi memperbaiki SOAP dan asesmen, penambahan diagnosis dan melengkapi resume. Dua orang diberikan akses untuk memastikan kelengkapan pengisian RME sesuai peraturan direktur. Kesalahan atau ketidaklengkapan dalam diagnosis dan tindakan, mengakibatkan pemberian kode penyakit dan tindakan tidak tepat sehingga hasil pengumpulan data dan pelaporan tidak akurat.Kesimpulan: Pengaturan pengaktifan kembali dan hak akses RME di RS X Kota Denpasar tidak sesuai Standar Prosedur Operasional dan Permenkes No. 24 Tahun 2022 tentang RM karena pengaktifan kembali melebihi 2 x 24 jam setelah pasien selesai dirawat. Evaluasi kebijakan dengan pelatihan, sosialisasi, kontrol akses serta pelaporan pelaksanaan RME dilakukan untuk menjaga kerahasiaan serta integritas data pasien.
Revitalisasi Desain Ruang Unit Kerja Rekam Medis Berdasarkan Aspek Ergonomi di Rumah Sakit Umum X Jember
Authors: Putra Dony Setiawan Hendyca , Cahyani Gandis Winur , Santi Maya Weka , Ardianto Efri Tri 
Published: December 2023

Latar Belakang: Ruang Unit Kerja Rekam Medis (UKRM) tidak hanya menyimpan dokumen penting akan tetapi sebagai pendukung dalam proses pelayanan kesehatan. Ruang UKRM di (Rumah Sakit Umum (RSU) X Jember belum memenuhi aspek ergonomi baik secara fisik dan lingkungan. Oleh karena itu perlu adanya perbaharuan desain ruang yang dapat mendukung kinerja petugas rekam medis sesuai ergonomi.Tujuan: Penelitian ini bertujuan untuk revitalisasi desain secara ergonomi ruang kerja unit rekam medis di RSU X Jember.Metode: Desain penelitian ini menggunakan metode kualitatif untuk analisis kebutuhan pembuatan desain ruang unit kerja rekam medis sesuai ergonomi. Teknik pengumpulan data melalui observasi, wawancara dan brainstorming. Desain UKRM menggunakan aplikasi SketchUp Pro 2023.Hasil: Ruang UKRM di RSU X Jember terdiri dari 3 ruangan dengan keadaan tepisah yakni ruang pendaftran, ruang kerja RM dan filing. Desain ruang UKRM baru diubah menjadi 4 ruangan yaitu pendaftaran berukuran 12m x 11m, ruang kerja petugas rekam medis berukuran 9,45m x 6,5m, filing berukuran 17,65m x 6,5m dan toilet berukuran 3,25m x 6,5m. Penyesuaian prasarana sesuai antropometri petugas dengan penambahan 11 rak penyimpanan, 2 meja dan 2 kursi, sedangkan lingkungan fisik perlu perencanaan penambahan atau pemeliharaan lampu dan ventilasi.Kesimpulan: Perubahan desain UKRM dengan memindahkan dan memperluas serta penyesuaian prasarana dan lingkungan fisik sesuai standar dan aspek ergonomi agar meningkatkan mutu pelayanan dan keselamatan pelayanan medis.
Determinantes de salud, estética y violencia en narrativas de streamers y su audiencia
Authors: Ramírez Leyva Flor Micaela 
Published: December 2023

La intención del presente texto es relacionar las narrativas verbales y visuales de los streamers a partir de tres dimensiones: determinantes de salud, estética y violencia. Los ejes conceptuales son los modelos de los determinantes de la salud, los estudios sobre estética e identidad, y de la violencia como espectáculo social. Mediante encuestas, entrevistas y etnografía en videos de streamers en Instagram, YouTube y TikTok, se identificaron actitudes egocéntricas y conductas dramáticas. Además, fue evidente la ostentación de sus prácticas y estilos de vida, como exaltación del yo virtual, que reproduce un modelo social y económico basado en el espectáculo y la ficción, pero con efectos reales discutibles y nocivos para las audiencias. Se sugiere cultivar y promover una mirada crítica en las audiencias jóvenes y adolescentes, escolarizados o no, y desarrollar propuestas creativas de entretenimiento menos triviales.