bluuebunny/crossref_metadata_2025_split huggingface dataset:
Reliability and Quality of the Nursing Care Planning Texts Generated by ChatGPT
Authors: Dağci Mahmut , Çam Funda , Dost Ayşe 
Published: November 2023

Background:The research on ChatGPT-generated nursing care planning texts is critical for enhancing nursing education through innovative and accessible learning methods, improving reliability and quality.Purpose:The aim of the study was to examine the quality, authenticity, and reliability of the nursing care planning texts produced using ChatGPT.Methods:The study sample comprised 40 texts generated by ChatGPT selected nursing diagnoses that were included in NANDA 2021-2023. The texts were evaluated by using descriptive criteria form and DISCERN tool to evaluate health information.Results:DISCERN total average score of the texts was 45.93 ± 4.72. All texts had a moderate level of reliability and 97.5% of them provided moderate quality subscale score of information. A statistically significant relationship was found among the number of accessible references, reliability (r= 0.408) and quality subscale score (r= 0.379) of the texts (P< .05).Conclusion:ChatGPT-generated texts exhibited moderate reliability, quality of nursing care information, and overall quality despite low similarity rates.
Differences in Test Anxiety Scores Among Baccalaureate Nursing Students and Nonnursing Students
Authors: Walker Cristen 
Published: November 2023

Background:
Test-taking is a prominent cause of anxiety for nursing students. Test anxiety may interfere with academic performance, program completion, and successful transition to practice. Prior research suggests that nursing students are more test-anxious than other students, yet this concept is not well studied.

Purpose:
This study examined differences between test anxiety in nursing and nonnursing students while comparing current trends related to academic level and gender.

Methods:
Using a cross-sectional design, participants completed the Test Anxiety Inventory as a measure of perceived test anxiety.

Results:
Minimal differences in scores based on major and academic level were found. Differences based on gender were noted with females reporting higher levels of test anxiety.

Conclusions:
Findings may help nurse educators better understand test anxiety and guide the implementation of supportive strategies to improve learning outcomes.
Screen-Based Patient Simulation
Authors: Altmiller Gerry , Jimenez Francisco A. , Wilson Cheryl 
Published: November 2023

Background:
Nursing education is moving toward competency-based education and assessment. Nurse educators will need to adopt strategies to develop and measure competence.

Purpose:
The purpose of this study was to determine if screen-based virtual patient simulation is an effective strategy to assist learners in developing competencies and subcompetencies required in nursing practice.

Methods:
Thirteen questions (6 assessment and clinical reasoning focused, 4 clinical judgment focused, 3 attitude and socialization to nursing focused), aligned with the competencies of the American Association of Colleges of Nursing Essentials, were developed for a pre-/posttest design to evaluate student competency development.

Results:
Senior nursing students (n = 52) participated; 1-tailed paired t test identified 12 of 13 items as statistically significant. Posttest scores were greater than pretest scores.

Conclusions:
The change in mean scores from pre- to posttest suggests screen-based virtual patient simulation scenarios improve learners' competence in addressing the patient's physical and psychological comfort and decreased caregiver biases.
A review on intelligent aid diagnosis for dysphagia using swallowing sounds
Authors: Li Dan , Wu Junhui , Jin Xiaoyan , Li Yanyun , Tong Beibei , Zeng Wen , Liu Peiyuan , Wang Weixuan , Shang Shaomei 
Published: November 2023

Abstract
Dysphagia, a widespread clinical condition in the elderly, can lead to malnutrition, aspiration pneumonia, and even death. Swallowing sounds emanate from vibrations that occur during the contraction of muscles in the mouth, pharynx, and laryngeal; the opening or closure of the glottis and esophageal sphincter; or the movement of food particles through the throat during swallowing. The development of wearable sensors, data science, and machine learning has spurred growing attention to the clinical method of monitoring swallowing sounds for accurate dysphagia diagnosis. This review delves into the acoustic theory foundation and the application of swallowing sound signal analysis methods, elucidating their potential clinical value for dysphagia diagnosis and treatment.
Design and preliminary evaluation of a low-cost three-dimensional biomechanical force plate
Authors: Zhu Disha , Wang Xuefeng , Shang Shaomei 
Published: November 2023

Abstract

Objective:
The three-dimensional (3D) force plate is a widely used device in biomechanical research, capable of measuring the ground reaction force (GRF) exerted on the sole of the foot. The forces of human joints are calculated by combining GRF with motion capture data. In the field of nursing and rehabilitation, evaluation of joint pressure can inform further therapy. However, its high cost often limits its application to a small population. Therefore, we aimed to design and manufacture a low-cost 3D force plate to address this issue, which will advance the evaluation of joint pressure in nursing practices.

Methods:
Through mechanical derivation and finite element method simulation, the feasibility of this 3D force plate was tested. We proposed a method based on simulation results to assist in calibration. Furthermore, we collected the GRF data of the author using the 3D force plate designed in this study. Then we imported this GRF data and the data obtained from motion capture into OpenSim.

Results:
The 3D force plate consisted of two 3D force sensors and a 600

300 mm board. The 3D force plate could measure the 3D reaction force between the sole of a subject’s foot and the ground. The 3D force plate was validated the usability in this study through theoretical calculation and a complete musculoskeletal analysis process.

Conclusion:
We have completed the design and practicality verification of this low-cost 3D force plate and provided a calibration method based on finite element method simulation assistance. Low-cost 3D force plates can accelerate the popularization and application of musculoskeletal analysis in the field of nursing and rehabilitation, which is helpful for precision health.
Usefulness of Heart-Type Fatty Acid–Binding Protein Measurement in Postmortem Urine Specimens
Authors: Hisamura Waka , Takasu Shojiro , Iwadate Kimiharu 
Published: November 2023

Abstract
Heart-type fatty acid–binding protein (HFABP) is a 15-kDa substance reported to pass through the renal tubules and be renally excreted. Therefore, it is possible that its concentration in the urine collected postmortem may reflect antemortem blood levels. We measured the postmortem urine concentration of HFABP in 94 forensic autopsy cases and compared it between acute myocardial infarction (AMI), sepsis, heat stroke cases, and asphyxia cases as control cases to examine its diagnostic validity. Kidney tissue collected at autopsy was immunostained with antibodies against HFABP to evaluate the correlation with the urinary measurements. Urinary HFABP was significantly higher in AMI, sepsis, and heat stroke cases than in asphyxia cases. Quantitative immunostaining results showed no significant differences between any 2 groups. The usefulness of kidney immunostaining for HFABP in elucidating the cause of death was low. Two reasons may explain the lack of significant differences in kidney immunostaining: nonspecific leakage of tubular epithelial HFABP into the tubules because of postmortem changes and oliguria due to dehydration caused by heat stroke. In conclusion, the measurement of urinary HFABP may be useful in elucidating the cause of death; however, the kidney HFABP immunostaining was not significantly different from AMI.
Lesions of the Cardiac Conduction System and Sudden Death
Authors: Cohle Stephen D. , Wygant Cassandra Maria 
Published: November 2023

Abstract
When a young previously healthy person dies suddenly, occasionally, the scene is noncontributory and the autopsy and drug screen are negative. In such cases, additional studies, including genetic assessment and cardiac conduction system examination, should be performed. We performed a literature search and reviewed our own material to identify possible or definite conduction system anomalies that may cause death. We identified intrinsic conduction system disease including cystic tumor of the atrioventricular node, atrioventricular node (cystic tumor of the AV node), and fibromuscular dysplasia of the atrioventricular node artery to be likely causes of death. Extrinsic causes, in which a generalized disease affects the conduction system, include tumors, autoimmune disease, infiltrative disorders, and others, are a second category of diseases that can affect the conduction system and cause atrioventricular block and sudden death.
Multiparametric Approach to Breast Cancer With Emphasis on Magnetic Resonance Imaging in the Era of Personalized Breast Cancer Treatment
Authors: Kataoka Masako , Iima Mami , Miyake Kanae Kawai , Honda Maya 
Published: November 2023

AbstractA multiparametric approach to breast cancer imaging offers the advantage of integrating the diverse contributions of various parameters. Dynamic contrast-enhanced magnetic resonance imaging (DCE-MRI) is the most important MRI sequence for breast imaging. The vascularity and permeability of lesions can be estimated through the use of semiquantitative and quantitative parameters. The increased use of ultrafast DCE-MRI has facilitated the introduction of novel kinetic parameters. In addition to DCE-MRI, diffusion-weighted imaging provides information associated with tumor cell density, with advanced diffusion-weighted imaging techniques such as intravoxel incoherent motion, diffusion kurtosis imaging, and time-dependent diffusion MRI opening up new horizons in microscale tissue evaluation. Furthermore, T2-weighted imaging plays a key role in measuring the degree of tumor aggressiveness, which may be related to the tumor microenvironment. Magnetic resonance imaging is, however, not the only imaging modality providing semiquantitative and quantitative parameters from breast tumors. Breast positron emission tomography demonstrates superior spatial resolution to whole-body positron emission tomography and allows comparable delineation of breast cancer to MRI, as well as providing metabolic information, which often precedes vascular and morphological changes occurring in response to treatment. The integration of these imaging-derived factors is accomplished through multiparametric imaging. In this article, we explore the relationship among the key imaging parameters, breast cancer diagnosis, and histological characteristics, providing a technical and theoretical background for these parameters. Furthermore, we review the recent studies on the application of multiparametric imaging to breast cancer and the significance of the key imaging parameters.
Financial Toxicity in Breast Implant–Associated Anaplastic Large Cell Lymphoma
Authors: Tesfaye Eliora A. , O'Neill Rebecca C. , McGregor Terri , Clemens Mark W. 
Published: November 2023

Background
Financial toxicity is a growing concern due to its considerable effects on medical adherence, quality of life, and mortality. The cost associated with breast implant-associated anaplastic large cell lymphoma (BIA-ALCL) is substantial from diagnosis to treatment, including adjuvant therapy and surgery. This study aims to assess the prevalence of financial toxicity in BIA-ALCL patients.

Methods
We performed a cross-sectional, survey-based study on women with confirmed cases of BIA-ALCL from December 2019 to March 2023. The primary study outcomes were financial toxicity measured by Comprehensive Score for Financial Toxicity (COST) score and patient-reported financial burden measured by the responses to the Evaluation of the Financial Impact of BIA-ALCL survey. Lower COST scores signify higher financial toxicity. Responses were linked to patient data extracted from the medical records.

Results
Thirty-two women treated for confirmed BIA-ALCL were included. Patients were all White and were diagnosed at a median age of 51 years (range, 41–65 years). The mean COST score was 27.9 ± 2.23. Lower COST scores were associated with receipt of radiotherapy (P = 0.033), exceeding credit card limits (P = 0.036), living paycheck to paycheck (P = 0.00027), requiring financial support from friends and family (P = 0.00044), and instability in household finances (P = 0.034).

Conclusions
Financial toxicity is prevalent in BIA-ALCL patients and has a substantial impact on patient reported burden. Insurance denial is frequent for patients with a prior history of cosmetic augmentation. Risk assessments and cost discussions should occur throughout the care continuum to minimize financial burden.
Liver transplantation for severe hepatic trauma: A multicenter analysis from the UNOS data set
Authors: Orozco Gabriel , Gupta Meera , Ancheta Alexandre , Shah Malay B. , Warriner Zachary , Marti Francesc , Mei Xiaonan , Desai Siddharth , Bernard Andrew , Gedaly Roberto 
Published: November 2023

BACKGROUND
Orthotopic liver transplantation (OLT) is rarely indicated after hepatic trauma but it can be the only therapeutic option in some patients. There are scarce data analyzing the surgical outcomes of OLT after trauma.

METHODS
We used the UNOS data set to identify patients who underwent OLT for trauma from 1987 to 2022 and compared them to a cohort of patients transplanted for other indications. Cox proportional hazard and multivariable logistic regression analyses were performed to assess predictors of graft and patient survival.

RESULTS
Seventy-two patients underwent OLT for trauma during the study period. Patients with trauma were more frequently on mechanical ventilation at the time of transplantation (26.4% vs. 7.6%, p < 0.001) and had a greater incidence of pretransplant portal vein thrombosis (12.5% vs. 4%, p = 0.002). Our 4:1 matched analysis showed that trauma patients had significantly shorter wait times, higher incidence of pretransplant portal vein thrombosis and prolonged length of stay. Trauma was associated with decreased overall graft survival (hazards ratio, 1.42; 95% confidence interval, 1.01–1.98), and increased length of stay (p = 0.048). There were no significant differences in long-term patient survival.

CONCLUSION
Unique physiological and vascular challenges after severe hepatic trauma might be associated with decreased graft survival in patients requiring liver transplantation.

LEVEL OF EVIDENCE
Prognostic and Epidemiological; Level III.
Engineering mice for female-biased progeny without impacting genetic integrity and litter size
Authors: Yosef Ido , Mahata Tridib , Xie Xuefeng , Chen Yuhuang , Bar-Joseph Hadas , Sun Qing-Yuan , Shalgi Ruth , Munitz Ariel , Gerlic Motti , Qimron Udi 
Published: November 2023

AbstractGenerating mammalian gametes with a skewed sex ratio has thus far eluded empirical confirmation. The utilization of such genetically engineered organisms would offer the potential to curtail the necessity for culling animals of undesirable sex, mitigate resource wastage, and alleviate superfluous labor burdens. In this study, we introduce a transgenic male mouse lineage, which consistently yields predominantly female progeny (comprising up to ∼90% of the total offspring). This accomplishment was made possible by integrating a controllable genetic cassette onto the Y chromosome. The cassette encodes dCas9 and RNA guides that selectively silence a spermatid maturation gene. After the separation of X and Y gametes during meiosis, gametes containing an X chromosome develop normally, while those harboring the engineered Y chromosome, subjected to dCas9 silencing of the spermatid maturation gene, do not mature properly. Indeed, some spermatozoa from the transgenic mice exhibit a unique morphology, associated with the absence of the maturation gene. Notably, the resultant female offspring do not inherit the genetically engineered Y chromosome and are thus not genetically modified. Importantly, the litter size of the transgenic mice remains unchanged compared to the wild type. These findings represent the potential of genetic engineering to yield sex-biased litters of full size without compromising genetic integrity, marking a pioneering advancement in this field of study.One sentence summaryY chromosome manipulation yields mostly female mice, preserving litter size without genetic alteration in females.Significance statementThis study demonstrates a groundbreaking approach to producing predominantly female offspring in mice without altering the genetic makeup of the females. By engineering a male mouse’s Y chromosome to prevent the proper development of male sperm, we can bias the offspring toward females while maintaining normal litter sizes and without genetically modifying the females. This technique has significant potential for reducing waste, labor, and ethical concerns in animal breeding.Graphical AbstractA proof of concept for the first mammal producing sexed semen may revolutionize the way for breeding animals such as cattle for the dairy industry and swine for the meat industry.
Phenology across scales: an intercontinental analysis of leaf-out dates in temperate deciduous tree communities
Authors: Delpierre Nicolas , Garnier Suzon , Treuil-Dussouet Hugo , Hufkens Koen , Lin Jianhong , Beier Colin , Bell Michael , Berveiller Daniel , Cuntz Matthias , Curioni Giulio , Dahlin Kyla , Denham Sander O. , Desai Ankur R. , Domec Jean-Christophe , Hart Kris M. , Ibrom Andreas , Joetzjer Emilie , King John , Klosterhalfen Anne , Koebsch Franziska , Hale Peter Mc , Morfin Alexandre , Munger J. William , Noormets Asko , Pilegaard Kim , Pohl Felix , Rebmann Corinna , Richardson Andrew D. , Rothstein David , Schwartz Mark D. , Wilkinson Matthew , Soudani Kamel 
Published: November 2023

AbstractAimTo quantify the intra-community variability of leaf-out (ICVLo) among dominant trees in temperate deciduous forests, assess its links with specific and phylogenetic diversity, identify its environmental drivers, and deduce its ecological consequences with regard to radiation received and exposure to late frost.LocationEastern North America (ENA) and Europe (EUR).Time period2009-2022Major taxa studiedTemperate deciduous forest trees.MethodsWe developed an approach to quantify ICVLo through the analysis of RGB images taken from phenological cameras. We related ICVLo to species richness, phylogenetic diversity and environmental conditions. We quantified the intra-community variability of the amount of radiation received and of exposure to late frost.ResultsLeaf-out occurred over a longer time interval in ENA than in EUR. The sensitivity of leaf-out to temperature was identical in both regions (-3.4 days per °C). The distributions of ICVLo were similar in EUR and ENA forests, despite the latter being more species-rich and phylogenetically diverse. In both regions, cooler conditions and an earlier occurrence of leaf-out resulted in higher ICVLo. ICVLo resulted in a ca. 8% difference of radiation absorption over spring among individual trees. Forest communities in ENA had shorter safety margins as regards the exposure to late frosts, and were actually more frequently exposed to late frosts.Main conclusionsWe conducted the first intercontinental analysis of the variability of leaf-out at the scale of tree communities. North American and European forests showed similar ICVLo, in spite of their differences in terms of species richness and phylogenetic diversity, highlighting the relevance of environmental controls on ICVLo. We quantified two ecological implications of ICVLo (difference in terms of radiation absorption and exposure to late frost), which should be explored in the context of ongoing climate change, which affects trees differently according to their phenological niche.
Giant genes are rare but implicated in cell wall degradation by predatory bacteria
Authors: West-Roberts Jacob , Valentin-Alvarado Luis , Mullen Susan , Sachdeva Rohan , Smith Justin , Hug Laura A. , Gregoire Daniel S. , Liu Wentso , Lin Tzu-Yu , Husain Gabriel , Amano Yuki , Ly Lynn , Banfield Jillian F. 
Published: November 2023

AbstractAcross the tree of life, gene lengths vary, but most are no more than a few thousand base pairs in length. The largest protein often reported is the ∼40,000 aa eukaryotic Titin. Even larger proteins may occur in the rapidly expanding set of metagenome-derived sequences, but their existence may be obscured by assembly fragmentation. Here, we leverage genome curation to complete metagenome-derived sequences that encode predicted proteins of up to 85,804 aa. Overall, the findings illuminate a huge knowledge gap related to giant proteins. Although predicted proteins of >30,000 aa occur in bacterial phyla such asFirmicutesandActinobacteria, they are most common in ca.Omnitrophota,ultra small bacteria that adopt predatory lifestyles. All full length giant genes encode numerous transmembrane regions and most encode divergent secA DEAD helicase domains.In silicostructural prediction of protein subregions was required to identify domains in unannotated protein segments, and revealed putative domains implicated in attachment and carbohydrate degradation. Many giant genes in new complete and near-completeOmnitrophotagenomes occur in close proximity to genes homologous to type II secretion systems as well as carbohydrate import systems. This, in combination with the domain content, suggests that many bacterial giant proteins enable prey adhesion and cell wall digestion during bacterial predation.
Inflammatory Recruitment of Healthy Hematopoietic Stem and Progenitor Cells in the Acute Myeloid Leukemia Niche
Authors: Chen Ding-Wen , Fan Jian-Meng , Schrey Julie M. , Mitchell Dana V. , Jung Seul K. , Hurwitz Stephanie N. , Perez Empar B. , Muraro Mauro , Carroll Martin , Taylor Deanne M. , Kurre Peter 
Published: November 2023

ABSTRACTInflammation in the bone marrow (BM) microenvironment is a constitutive component of leukemogenesis in acute myeloid leukemia (AML). Current evidence suggests that both leukemic blasts and stroma secrete proinflammatory factors that actively suppress the function of healthy hematopoietic stem and progenitor cells (HSPCs). HSPCs are also cellular components of the innate immune system, and we reasoned that they may actively propagate the inflammation in the leukemic niche. In two separate congenic models of AML we confirm by evaluation of the BM plasma secretome and HSPC-selective single-cell RNA sequencing (scRNA-Seq) that multipotent progenitors and long-lived stem cells adopt inflammatory gene expression programs, even at low BM leukemic burden. In particular, we observe interferon gamma (IFN-γ) pathway activation, along with secretion of its chemokine target, CXCL10. We show that AML-derived nanometer-sized extracellular vesicles (EVAML) are sufficient to trigger this inflammatory HSPC response, bothin vitroandin vivo. Altogether, our studies indicate that HSPCs are an unrecognized component of the inflammatory adaptation of the BM by leukemic cells. The pro-inflammatory conversion and long-lived presence of HSPC in the BM along with their regenerative re-expansion during remission may impact clonal selection and disease evolution.