bluuebunny/crossref_metadata_2025_split huggingface dataset:
Quantification of PAHs, PCBs and Pesticides adsorbed by plastic waste in the Togolese marine environment
Authors: SIZING Badjagoma , KOLEDZI Edem Komi , SEMA Alaki-Issi Massimapatom , KROU Nitale M'Balikine 
Published: November 2023

Abstract

The study aims to determine the different pollutants adsorbed by plastic waste along the Togolese coast. To this end, nine samples were taken from three different sites and analysed by GC-MS and LC-MS. Apart from pesticides, which were found in only one sample, PAHs and PCBs were adsorbed by all nine samples collected. Thus, the total concentrations of PAHs and PCBs at the different sites give respectively in ng/g; at Aneho, 677.16 and 26.95 on the LDPE debris, those of PP are 195.92 and 8.85; 136.34 and 4.04 on the PET sample. At Kodjoviakope, 596.5 and 14.6 on the LDPE sample; those of PP are 196.46 and 11.37; 105.15 and 1.6 on the PET sample. In the Fishing Port, 1182.56 and 9.87 on the LDPE sample, PP 336.57 and 13.04; 274.06 and 2.74 on the PET sample. There is a need to take measures to eradicate their presence at sea.
Priority effects and microbial cross-feeding shape zoonotic agent spread in broiler chickens
Authors: Marcos Sofia , Odriozola Iñaki , Langa Jorge , Baldi Germana , Sahin Eray , Mak Sarah Siu Tze , Pless Louisa , Tarradas Joan , Estonba Andone , Alberdi Antton 
Published: November 2023

Abstract

Unravelling the colonisation dynamics and physiological effects of zoonotic bacteria such as Campylobacter is imperative to prevent foodborne diseases. We employed a hologenomic approach to jointly analyse metabolic networks and gene expression of the caecal microbiota, with the intestinal gene expression of 613 broiler chickens that did and did not undergo an opportunistic Campylobacter colonisation. We report that an early development of a distinct microbial enterotype enriched with Bacteroides fragilis_A, changed the community to a functional profile that likely benefited Campylobacter through production of key metabolites. The resulting enterotype was not associated with a host immune response, but exhibited an enriched and energetically more demanding functional repertoire compared to the standard enterotype, which could have caused the growth decline observed in Campylobacter-colonised animals. We provide unique insights into microbe-microbe and host-microbe interactions, which point to the early-stage microbiota-development as a relevant factor for later Campylobacter spread in broiler chickens.
Post-Discharge Rebleeding in Splenic Injury: A Predictive Model
Authors: Chen Jian-Han , Hsieh Pie-Wen , Chen Chung-Yen , Yu Po-Chin , Huang Yi-Kai , Lin Hung-Yu 
Published: November 2023

Abstract

BACKGROUND:This study aimed to develop a predictive model for identifying patients with high rebleeding risk after discharge from treatment without splenectomy and embolization for splenic injury.
METHODS: Data were extracted from the 1996–2013 National Health Insurance Research Database. Adult patients aged ≥18 years with splenic injury (ICD-9-CM codes 865.01–865.09) from 2000 to 2012 were included. Patients who died, underwent splenectomy (ICD-9-OP codes 41.5, 41.42,41.43, and 41.95) or transcatheter arterial embolization (TAE) (ICD-9-OP codes 39.79 and 99.29) on the first admission were excluded. The primary endpoint was rebleeding, which was identified if patients underwent splenectomy or TAE at 180 days after discharge. The patients were randomly divided into derivation (80%) and validation (20%) groups for analyze.
RESULTS: 6,140 were finally included. After conducting a multivariate analysis on the derivation group (n=4916), six risk factors were identified and assigned with different scores to generate the Delayed Splenic Bleeding System (DSBS) based on the coefficient of variables significantly related to rebleeding: age <54 years (1 point), male sex (1 point), length of hospitalization ≤6 days (1 point), non-traffic accident-induced injury (1 point), ISS ≥16 (1 point), and history of congestive heart failure (2 points). The rebleeding rates at 180 days after discharge was significantly higher with DSBS score >3 (3.4%) than with DSBS score ≤3 (0.8%) (p<0.001); similar results were observed in the validation group (1.0% for DSBS score ≤3 vs. 4.2% for DSBS score >3, p=0.002). The areas under the ROC curve were 0.701 (p<0.001) and 0.675 (p=0.009) for the derivation and validation groups, respectively. The DSBS showed good calibration in the derivation group (Hosmer-Lemeshow χ2=2.607, p=0.272) and validation group (Hosmer-Lemeshow χ2=3.009, p=0.222).
CONCLUSIONS: Our prediction model (i.e., the DSBS) effectively predicted the 180-day rebleeding risk, which could enable stratification in further studies or pre-discharge treatment for blunt splenic injury.
BpIAA10 interacts with BpIAA7 and BpARF19 to regulate the growth and differentiation of embryonic leaves in birch (Betula platyphylla)
Authors: Xu Wendi , Wang Jiaqi , Wang Shuo , Chen Su , Han Rui , Yan Bin , Jiang Jing , Liu Guifeng 
Published: November 2023

Abstract
The Auxin/Indole acetic acid (Aux/IAA) family is an important class of auxin-response genes involved in leaf development in Arabidopsis. However, the biological function of these genes remains unclear in perennial wood plants. In this study, we identified an Aux/IAA10 gene (BpIAA10) from birch (Betula platyphylla) that is associated with growth of embryonic leaves. The result was confirmed by gain- and loss-of-function analysis of BpIAA10. Transgenic birch overexpressing (OE) and repressing (RE) BpIAA10 exhibited significantly increased numbers of embryonic leaves and stipules than non-transgenic lines (NT). The IAA concentration was increased by 3.50 and 3.61-fold in OE and RE lines than NT, respectively. Yeast two-hybrid and bimolecular fluorescence complementation (BiFC) analysis revealed that BpIAA10 specifically interacts with BpIAA7 and BpARF19 during leaf development. In addition, we found both overexpression and repression of BpIAA10 affected the expression of auxin biosynthesis and metabolism genes, auxin response genes, and leaf development genes. All these results indicated that BpIAA10 is involved in the differentiation and growth of embryonic leaves by specific interactions and complex regulation with components of the birch auxin response pathway. Our findings provide insights into leaf growth and differentiation in perennial trees.
Endophytes: a uniquely tailored source of antibiotic adjuvants
Authors: Moussa Ashaimaa Y. 
Published: November 2023

Abstract
Multidrug resistance is growing at an alarming rate risking the loss of lives of more than 10 million people per year by 2050. Solutions include rational use of antibiotics and more effectively the use of drugs that reduce resistance or completely obliterate them. Several plant extracts were reported as active antimicrobial agents, but their supply problem and low rate of compound isolation retarded their advancement in this field. Here endophytes come to play due to their high yield production and inherent nature to produce antimicrobial molecules where 40%, 45% and 17% of antibacterial agents were obtained from fungi, actinomycetes, and bacteria, respectively, whose secondary metabolites revealed effectiveness against resistant microbes such as Bacillus sp., MRSA, MRSE, and Shigella flexneri. Biological activities included anticancer, antimicrobial, antiviral and anti-inflammatory effects. Endophyte’s role was not confined to bactericidal effect but extended to other mechanisms against MDR microbes, among which was the adjuvant role or the “magic bullets" that could revive obsolete antibiotics again. Scarce focus was given to antibiotic adjuvants, and many laboratories today just screen for the antimicrobial activity without considering combinations with traditional antibiotics, which means real loss of promising resistance combating molecules. This review, comprehensively and for the first time, sheds light on the significance of endophytes secondary metabolites in solving AMR problem as AB adjuvants. Examples of promising antibiotic adjuvants were listed from endophytes showing their potency in rescuing bacterial susceptibility by folds magnitude.
Hospice Care in Pediatrics
Authors: Pan Jumei , Ali Khan Akhtar 
Published: November 2023

Abstract
Background
Hospice care is the primary field of public health that establishes the minimum standards of care for patients who are nearing the end of their lives. All individuals, irrespective of their race, social status, or cultural heritage, should be able to obtain this healthcare. Scientific literature has brought attention to the inequalities in healthcare based on race and ethnicity. The focus of this article is to examine previous research on the impact of hospice care on infected children, parents, and siblings. Providing hospice care can help children maintain a positive attitude during their treatment.
Objective
The review is based on prior research, and extensive investigation is being made into pediatric hospice care.
Methods
Various keywords were utilized for the research. PubMed, Medline, and other scientific sources were utilized to ensure the accuracy of the collected scientific research data. The collected data underwent inclusion and exclusion criteria. Ultimately, twenty-seven articles were chosen.
Results
From 2015 to 2022, 27 studies were conducted involving 115 families. The findings showed the positive impact of hospice care on both parents and children. Additionally, the research also delved into the specific needs of children in hospice care.
Conclusion
Children who receive hospice care tend to have a better quality of life.
Enhanced Critical Charge (Q cr ) and Highly Reliable Read-Decoupled Radiation-Hardened 14T SRAM cell for Aerospace Application
Authors: Ahirwar Rachana , Pattanaik Manisha , Srivast Pankaj 
Published: November 2023

Abstract
Due to technological advancements, the size of transistors and the spacing between them is decreasing, resulting in a reduction in the critical charge of sensitive nodes. This decrease in critical charge makes these nodes more susceptible to disturbances and errors in static random access memory (SRAM) cells used in aerospace applications. To address this, a proposed 14T SRAM cell with polarity hardening technology is introduced in this paper, which reduces the number of sensitive nodes and enables recovery from single-event-multiple-effect (SEME) based on all single-event upset (SEU) recovery techniques. The simulation results conducted on the United Microelectronics Corporation (UMC) 65 nm CMOS commercial standard process demonstrate that the proposed 14T SRAM cell reduces both SEU and SEME. A comparative study is performed between the proposed 14T cell and other radiation-hardened SRAM cells, including DICE, SAR14T, RSP14T, RHBD14T, and NRHC14T, to assess the relative performance of the proposed cell. The proposed 14T cell for SRAM exhibits 40.42% and 21.39% improvements in write stability compared to existing cells like DICE and RSP14T, as well as 25.08% and 19.09% improvements in read stability compared to RHBD14T and RSP14T. It also shows enhancements of 81.88%, 76.82%, 57.83%, and 10.25% in critical charge value compared to RHBD14T, NRHC14T, SAR14T, and RSP14T, respectively, better stability, and improved overall performance, making it suitable for aerospace applications. Monte Carlo (MC) simulations have verified its ability to recover from SEU and SEME, with zero percent failure probability during read, write, and hold operations at different supply voltages.
Intention to use telemonitoring for chronic illness management and its associated factors among Nurses and Physicians at Public Hospitals in Bahir Dar, Northwest Ethiopia: Using modified UTAUT-2 model
Authors: Alameraw Temesgen Ayenew , Asemahagn Mulusew Andualem , Gashu Kassahun Dessie , Walle Agmasie Damtew , Kelkay Jenberu Mekurianew , Mitiku Abebaw Belew , Dube Geleta Nenko , Guadie Habtamu Alganeh 
Published: November 2023

Abstract

Background: Chronic illnesses require continuous medical attention as well as patient self-management. Telemonitoring has the potential to maximize professional productivity, continuous medical attention and improve patient self-care management as well as reduce hospitalization and cost of care using these applications. Despite all the benefits, little is known about nurses' and professionals’ intentions to use telemonitoring technologies in Ethiopia. Therefore, this study assessed nurses' and professionals’ intention to use telemonitoring and its associated factors in Ethiopia.
Methods: A cross-sectional study was conducted among 781 randomly selected nurses and physicians working at Public Hospitals in Bahir Dar City, Northwest Ethiopia. The sample size was allocated proportionally to each hospital and the profession based on the number of staffs was applied to give a chance for all. A simple random sampling technique was applied to obtain the sample. Trained data collectors collected data using a self-administered questionnaire. Data were entered into Epi-data version 4.6 and exported to SPSS version 25 for further cleaning and descriptive statistical analysis. The extent of the relationship between variables was determined using AMOS 23 structural equation modeling (SEM).
Result:The response rate was 732/781 (93.7%) of them 55.7% (408/732) were male, and two-thirds 67.6 % (495/732) of participants were nurses. The proportion of intention to use telemonitoring was 55.9% with 95.0%: CI: [52.3-59.6]. Performance expectancy (β=0.366, 95% CI: [0.250,0.482]), effort expectancy (β=0.145, 95% CI: [0.053, 0.231]), facilitating condition (β=0.261, 95% CI: [0.146, 0.380]) and habit (β=162, 95% CI: [0.064, 0.262]) has a positive effect on the intention to use telemonitoring. The relationship between effort expectancy and intention to use telemonitoring was positively moderated by age and gender. Being young and males were found to be positive influencers in the relationship. The relationship between facilitating conditions and intention to use telemonitoring was positively moderated by age and significantly associated with adults.
Conclusion More than half of nurses and physicians at public hospitals in Bahir Dar has the intention to use telemonitoring. Performance expectancy, effort expectancy, facilitating condition, and habit were statistically significant factors of intention to use telemonitoring.
Quasi-dynamic opposite learning enhanced Runge-Kutta optimizer for solving complex optimization problems
Authors: Turgut Oguz Emrah , Turgut Mert Sinan 
Published: November 2023

Abstract

The Runge-Kutta Optimization (RUNGE) algorithm is a recently proposed metaphor-free metaheuristic optimizer borrowing practical mathematical foundations of the famous Runge-Kutta differential equation solver. Despite its relatively new emergence, this algorithm has several applications in various branches of scientific fields. However, there is still much room for improvement as it suffers from premature convergence resulting from inefficient search space exploration. To overcome this algorithmic drawback, this research study proposes a brand-new quasi-dynamic opposition-based learning (QDOPP) mechanism to be implemented in a standard Runge-Kutta optimizer to eliminate the local minimum points over the search space. Enhancing the asymmetric search hyperspace by taking advantage of various positions of the current solution within the domain is the critical novelty to enrich general diversity in the population, significantly improving the algorithm's overall exploration capability. To validate the effectivity of the proposed RUNGE-QDOPP method, thirty-four multidimensional optimization benchmark problems comprised of unimodal and multimodal test functions with various dimensionalities have been solved, and the corresponding results are compared against the predictions obtained from the other opposition-based learning variants as well as some state-of-art literature optimizers. Furthermore, six constrained engineering design problems with different functional characteristics have been solved, and the respective results are benchmarked against those obtained for the well-known optimizers. Comparison of the solution outcomes with literature optimizers for constrained and unconstrained test problems reveals that the proposed QDOPP has significant advantages over its counterparts regarding solution accuracy and efficiency.
Particle tracking in snow avalanches with in situ calibrated inertial measurement units
Authors: Winkler Robert , Neuhauser Michael , Neurauter Rene , Erlacher Felix , Steinkogler Walter , Fischer Jan-Thomas 
Published: November 2023

Abstract
In the course of an artificially triggered avalanche, a particle tracking procedure is combined with supplementary measurements, including Global Navigation Satellite System (GNSS) positioning, Terrestrial Laser Scanning (TLS), and Doppler radar measurements. Specifically, an Inertial Measurement Unit (IMU) is mounted inside a rigid sphere and placed in the avalanche track. It is entrained by the moving snow, measuring translational accelerations, angular velocities, and the flux density of Earth’s magnetic field. Based on this data, we present a threefold analysis: (i) a qualitative data interpretation, identifying different particle motion phases which are associated to corresponding flow regimes, (ii) a quantitative time integration algorithm, determining the corresponding particle trajectory and associated velocities on the basis of standard sensor calibration, and (iii) an improved quantitative evaluation relying on a novel in situ sensor calibration technique, which is motivated by the limitations of the given data set. The final results, i.e. the evolution of the angular orientation of the sensor unit, translational and rotational velocities, and estimates of the sensor trajectory, are assessed with respect to their reliability and relevance for avalanche dynamics as well as for future design of experiments.
Smart water network infrastructures
Authors: Gabbar Hossam A. , Islam Sultan , Ramadan Ahmed 
Published: November 2023

Abstract
This paper presents a solution to convert the conventional water network into a smart water network (SWN). Scenarios are synthesized for water recycling inside buildings with less water consumed, minimizing the overall cost. Multiphysics modelling and simulation are conducted with Hysys and Ansys - Fluent in calculating the water flow quantity, pressure of the water network and velocity of water inside the pipe network. Four scenarios are synthesized and modelled for a selected mall building case study. These scenarios reduce the water consumption in the mall from 100% to 29.4%, with a cost-saving of more than 60%.
Exploring the Targets of Dengue Virus and Designs of Potential Inhibitors
Authors: Nath Sayan , Malakar Piyali , Biswas Baisakhi , Das Suryatapa , Sabnam Nahid , Nandi Sisir , Samadder Asmita 
Published: November 2023

Background:
Dengue, a mosquito-borne viral disease spread by the dengue virus
(DENV), has become one of the most alarming health issues in the global scenario in recent
days. The risk of infection by DENV is mostly high in tropical and subtropical areas of the
world. The mortality rate of patients affected with DENV is ever-increasing, mainly due to a lack
of anti-dengue viral-specific synthetic drug components.

Introduction:
Repurposing synthetic drugs has been an effective tool in combating several pathogens,
including DENV. However, only the Dengvaxia vaccine has been developed so far to
fight against the deadly disease despite the grave situation, mainly because of the limitations of
understanding the actual pathogenicity of the disease.

Methods:
To address this particular issue and explore the actual disease pathobiology, several
potential targets, like three structural proteins and seven non-structural (NS) proteins, along with
their inhibitors of synthetic and natural origin, have been screened using docking simulation.

Results:
Exploration of these targets, along with their inhibitors, has been extensively studied in
culmination with molecular docking-based screening to potentiate the treatment.

Conclusion:
These screened inhibitors could possibly be helpful for the designing of new congeneric
potential compounds to combat dengue fever and its complications.
Clodronic Acid has Strong Inhibitory Interactions with the Urease Enzyme of Helicobacter pylori: Computer-aided Design and in vitro Confirmation
Authors: Fath Mohsen Karami , Khalili Saeed , Boojar Masoud Mashhadi Akbar , Hashemi Zahra Sadat , Zarei Mahboubeh 
Published: November 2023

Background:
Helicobacter Pylori (HP) infection could lead to various gastrointestinal
diseases. Urease is the most important virulence factor of HP. It protects the bacterium
against gastric acid.

Objective:
Therefore, we aimed to design urease inhibitors as drugs against HP infection.

Methods:
The DrugBank-approved library was assigned with 3D conformations and the structure
of the urease was prepared. Using a re-docking strategy, the proper settings were determined
for docking by PyRx and GOLD software. Virtual screening was performed to select the
best inhibitory drugs based on binding affinity, FitnessScore, and binding orientation to critical
amino acids of the active site. The best inhibitory drug was then evaluated by IC50 and the diameter
of the zone of inhibition for bacterial growth.

Results:
The structures of prepared drugs were screened against urease structure using the determined
settings. Clodronic acid was determined to be the best-identified drug, due to higher
PyRx binding energy, better GOLD FitnessScore, and interaction with critical amino acids of
urease. In vitro results were also in line with the computational data. IC50 values of Clodronic
acid and Acetohydroxamic Acid (AHA) were 29.78 ± 1.13 and 47.29 ± 2.06 μg/ml, respectively.
Diameters of the zones of inhibition were 18 and 15 mm for Clodronic acid and AHA, respectively.

Conclusion:
Clodronic acid has better HP urease inhibition potential than AHA. Given its approved
status, the development of a repurposed drug based on Clodronic acid would require less
time and cost. Further, in vivo studies would unveil the efficacy of Clodronic acid as a urease
inhibitor.