bluuebunny/crossref_metadata_2025_split huggingface dataset:
Exploring the potential of spice‐derived phytochemicals as alternative antimicrobial agents
Authors: Wong Young Y. , Chow Yit‐Lai 
Published: December 2023

AbstractThe emergence and spread of pathogenic bacterial resistance to many antibiotics are on the rise globally, thereby posing a significant threat to public health. In response, scientists are actively investigating alternative therapeutic agents to combat antibiotic‐resistant microorganisms. This review focuses on the antimicrobial effects of commonly consumed spices, namely garlic, chilli peppers, turmeric, ginger and black pepper, which have shown promising results in previous research. The review highlights the key phytochemicals, including allicin, ajoene, capsaicin, dihydrocapsaicin, curcumin, 6‐gingerol, 6‐shogaol and piperine, responsible for their antimicrobial activities. Various pharmacological experiments to elucidate the action mechanism and metabolism of those bioactive compounds are described. Moreover, the synergistic effects of these phytochemicals with conventional antibiotics are discussed, emphasizing the potential to reduce the required antibiotic dosage for effective microbial inhibition. The review also addresses the gaps in current research, such as the variations in antimicrobial assay results across different research groups and the incomplete understanding of the synergistic mechanisms between antibiotics and phytochemicals. Finally, future research directions and opportunities are suggested to further explore the antimicrobial potential of these spice‐derived phytochemicals and bridge the existing knowledge gaps.
A Distibene with Extremely Long Sb=Sb Distance and Related Heavier Dipnictenes from Salt‐Free Metathesis Reactions
Authors: Roller Clara A. , Doler Berenike , Steller Beate G. , Saf Robert , Fischer Roland C. 
Published: December 2023

AbstractConversions of organoelement diamides, ArDippE(NMe2)2 (E=Sb, Bi; ArDipp=C6H3‐2,6‐Dipp2), with Ph2SnH2 as reducing agent gave access to low‐valent, heavier group 15 dimers ArDippSb=SbArDipp and ArDippBi=BiArDipp, while only readily removable byproducts (i. e. dihydrogen, amines) and cyclo‐(Ph12Sn6) are generated during the reaction. Moreover, experiments involving the reaction of organoantimony hydride species Ar*2SbH (Ar*=C6H2‐2,6‐(Ph2CH)2‐4‐iPr) with Bi(NEt2)3 yielded a second novel distibene, Ar*Sb=SbAr*, with the currently longest Sb−Sb bond distance of 2.8605(5) Å in a distibene. In conversions of TbbSnH3 (Tbb=C6H2‐2,6‐(CH(SiMe3)2)2‐4‐tBu) with Bi(NEt2)3, ligand migration resulted in the isolation of TbbBi=BiTbb. Remarkably, the herein reported novel inorganic coupling route enables preparation and isolation of heavier dipnictenes without the formation of inorganic salts. All four low‐oxidation state compounds were isolated and subsequently characterized using state of the art techniques, i. e. X‐ray crystallography, NMR and UV/Vis spectroscopy.
Effect of Tethered Sulfur Ligands on the Association Constants of Dirhodium(II,II) Paddlewheel Complexes
Authors: Moore Desiree , Ogunyemi Bukola , Nalaoh Phattananawee , Darko Ampofo 
Published: December 2023

AbstractHerein we report on the association constants (Ka) of dirhodium(II,II) complexes bearing tethered thioether or sulfoxide ligands in the presence of binding analytes. The effect of substituent and tether length modifications on Ka and the stability of the complexes were analyzed by UV‐vis using pyridine and cysteine as binding analytes of interest. When pyridine was the incoming exogenous species, dirhodium(II,II) complexes with tethered sulfur ligands reduced the axial coordination of pyridine by up to four‐fold when compared to dirhodium(II,II) complexes without tethered axial coordination. Tuning the tethered sulfur coordination through changes in tether length, substituent, and electronics resulted in Ka values that spanned 2.6×103 M−1 to 8.1×103 M−1. The differences in Ka were correlated with structural features of crystals obtained from single crystal X‐ray diffraction and results pointed to release of strain as a factor in the association constants. Interestingly, cysteine interactions were greater for complexes with tethered, axial ligands than those without, alluding to an alternate mode of coordination with cysteine. These results demonstrate the tunability of tethered, axial coordination on dirhodium(II,II) paddlewheel complexes and provide access to controlled binding of exogenous species.
Transition‐Metal‐Free C−H Alkylation of Cyclic Aldimines with Alkylboronic Acid
Authors: Zhou Yu , Cui Yangbo , Huang Hangfei , Zhang Jun‐Qi , Xu Yang , Ren Hongjun , Dong Zhi‐Bing 
Published: December 2023

AbstractMolecular oxygen‐mediated C−H bond alkylation of cyclic aldimines has been reported, which avoids the use of transition metals and additional oxidants. This method allows straightforward access to a series of cyclic aldimine derivatives through a free radical course. Furthermore, this transformation features mild conditions, excellent yields and good functional group tolerance.
Contrasted Antibiotics and Pesticides Occurrence in Fish Exposed In Situ to Urban Effluents: A 20-Day Caging Experiment
Authors: Marchand Etienne , Petit Fabienne , Alliot Fabrice , Blanchoud Hélène , Costantini David , Guigon Elodie , Martin Nicolas , Traore Sira , Goutte Aurélie 
Published: December 2023

Abstract
Urban freshwater ecosystems receive a wide array of organic pollutants through wastewater-treatment plant (WWTP) discharges and agricultural runoff. Evaluating the fate and effects of antibiotics and pesticides can be a challenging task, especially the effects on freshwater vertebrates because of their abilities to metabolize and excrete these chemicals and because of their high mobility and escape behavior when exposed to stressful environmental conditions. In the present study, 37 wild gudgeons (Gobio gobio) were caged for a period of up to 20 days, upstream and downstream of a WWTP effluent discharge in the Orge River (a tributary of the Seine River, France). Levels of pesticides and antibiotics in fish muscles were monitored weekly and compared with environmental contamination (water and sediments). Our results highlighted a slight bioaccumulation of pesticides in the gudgeon muscles at the downstream site after 20 days of exposure. Concerning antibiotics, ofloxacin was the most detected compound in fish muscles (85% of occurrence) and ranged from undetectable to 8 ng g–1 dry weight. Antibiotic levels in fish muscle were not higher at the downstream site and did not increase with exposure duration, despite high levels in the water (up to 29 times greater than upstream). Potential ecotoxicological effects were also evaluated: Body condition did not differ between the caging location and exposure time. Three oxidative status markers in the fish livers showed significant shifts after 14 days of caging. Our results suggest a high clearance rate of antibiotics and, to a lesser extent, of pesticides in wild gudgeons, which could be explained by changes in xenobiotic metabolism with pollutant exposure. Environ Toxicol Chem 2024;43:701–711. © 2023 SETAC
A phased workflow to define permit‐ready locations for large volume CO2 injection and storage
Authors: Trevino Ramon H. , Hovorka Susan D. , Dunlap Dallas B. , Larson Richard C. , Hentz Tucker F. , Hosseini Seyyed A. , Bhattacharya Shuvajit , DeAngelo Michael V. 
Published: December 2023

AbstractTo‐date, only two UIC Class VI permits have been issued by the US Environmental Protection Agency. We illustrate a four‐phase workflow to first identify regional storage resources and then down‐select sites to yield permit‐ready locations that can accept and store large volumes of CO2. Specific permit requirements should guide objectives and define deliverables of respective workflow phases. In the first phase we used available regional data and screened structure and injection zones to locate resources that match CO2 volumes planned to be captured. Available data were also used to assess presence and depth of usable groundwater, the key resource being protected via permitting. We then used advanced, closed‐form, analytical solutions (EASiTool) to estimate CO2 injectivity into each hydrologically connected injection compartment. In the second phase we acquired and conditioned additional wireline logs and leased available seismic datasets. We interpreted the depositional systems from wireline well‐log character and mapped sandbody geometry to interpolate injection and confining‐zone distribution. Using available data, we mapped faults and locations of freshwater and overpressure (or other capacity‐limiting geologic parameters) in more detail. In the third phase, we used the augmented geologic data to develop a static model for the selected area, extracted the areas of highest interest, and generated and ran dynamic (flow) models. In a fourth phase, we reduced major uncertainties identified in earlier phases. Our case study indicates that to complete preparation of a permit application requires (1) improved lithologic characterization information (thicknesses and horizontal and vertical connectivity) and (2) better definition of poorly defined local faults. © 2023 The Authors. Greenhouse Gases: Science and Technology published by Society of Chemical Industry and John Wiley & Sons Ltd.
Tumor volumes in T3 supraglottic cancers treated with radiotherapy in the modern era: A study of the Canadian Head & Neck Collaborative Research Initiative
Authors: Malik Nauman H. , Fu Rui , Hainc Nicolin , Noel Christopher W. , de Almeida John R. , Hosni Ali , Huang Shao Hui , Yu Eugene , Dzioba Agnieszka , Leung Andrew , Mangat Arvindpaul , MacNeil Danielle , Nichols Anthony C. , Hiremath Shivaprakash B. , Chakraborty Santanu , Jooya Alborz , Gaudet Marc , Johnson‐Obaseki Stephanie , Whelan Jonathan , Forghani Reza , Hier Michael P. , Morand Grégoire , Sultanem Khalil , Dort Joseph , Lysack John , Matthews Wayne , Nakoneshny Steven , Gill Gia , Globerman Adam , Kerr Paul , Maralani Pejman , Karam Irene , Eskander Antoine 
Published: December 2023

AbstractPurposeTo evaluate the association of primary tumor volume (TV) with overall survival (OS) and disease‐free survival (DFS) in T3 N0‐3M0 supraglottic cancers treated with intensity‐modulated radiotherapy (IMRT).MethodsThis was a retrospective cohort study involving 239 patients diagnosed with T3 N0‐3M0 supraglottic cancers between 2002 and 2018 from seven regional cancer centers in Canada. Clinical data were obtained from the patient records. Supraglottic TV was measured by neuroradiologists on diagnostic imaging. Kaplan–Meier method was used for survival probabilities, and a restricted cubic spline Cox proportional hazards regression analysis was used to analyze TV associations with OS and DFS.ResultsMean (SD) of participants was 65.2 (9.4) years; 176 (73.6%) participants were male. 90 (38%) were N0, and 151 (64%) received concurrent systemic therapy. Mean TV (SD) was 11.37 (12.11) cm3. With mean follow up (SD) of 3.28 (2.60) years, 2‐year OS was 72.7% (95% CI 66.9%–78.9%) and DFS was 53.6% (47.4%–60.6%). Increasing TV was associated (per cm3 increase) with worse OS (HR, 1.01, 95% CI 1.00–1.02, p < 0.01) and DFS (HR, 1.01, 95% CI 1.00–1.02, p = 0.02).ConclusionsIncreasing primary tumor volume is associated with worse OS and DFS in T3 supraglottic cancers treated with IMRT, with no clear threshold. The findings suggest that patients with larger tumors and poor baseline laryngeal function may benefit from upfront laryngectomy with adjuvant radiotherapy.
Investigating the advantages and disadvantages of electronic logbooks for education goals promotion in medical sciences students: A systematic review
Authors: Paydar Somayeh , Esmaeeli Erfan , Ameri Fatemeh , Sabahi Azam , Meraji Marzieh 
Published: December 2023

AbstractBackground and AimsElectronic logbook (E‐Logbook) is one of the practical software in medical science that serves as an auxiliary tool for comprehensive education, formative evaluation, and student learning documentation in clinical education. E‐logbooks are available to people on the Internet without any time or place restrictions. Experts' familiarity with e‐logbooks and their advantages and disadvantages can be effective in their better design so professors and students can use their potential benefits. Therefore, this study examines the advantages and disadvantages of an e‐logbook.MethodsThis systematic review was conducted until June 13, 2022, by searching relevant keywords such as logbook, e‐logbook, and medical students in PubMed, Scopus, and Web of Science databases. Data were extracted using the data extraction form. The contents of the studies were analyzed based on the study's aim. The results of the analyses were presented in the form of descriptive statistics (tables and figures).ResultsOut of 365 retrieved studies, 13 were selected to investigate the advantages and disadvantages of e‐logbooks. Most studies were conducted in Pakistan (n = 4) and focused on medical students with different specialties (n = 10). The advantages and disadvantages of e‐logbooks were classified into nine and four categories, respectively. Most advantages of e‐logbooks were related to monitoring and evaluating the performance of students and instructors (n = 11). Their most disadvantages were associated with hardware and software (n = 8).ConclusionAccording to the results, e‐logbooks can improve clinical education, provide feedback to people, control the achievement of educational goals, and increase professor−student interaction. Hence, it is recommended to address their disadvantages and barriers to improve the quality of students' performance.
Investigating the factors related to protective behaviors against COVID‐19 in healthcare workers: Application of extended parallel process model
Authors: Noroozi Masir Marzieh , Tarrahi Mohammad Javad , Fathian Dastgerdi Zohreh , Rahimi Majid 
Published: December 2023

AbstractBackground and AimsPreventive behaviors against coronavirus disease 2019 (COVID‐19) are important, and messages that create a sense of danger are necessary to create these behaviors. One of the widely used models for designing risk messages is the Extended Parallel Process Model (EPPM). The present study was conducted to investigate the factors related to protective behaviors against COVID‐19 in the personnel of the health department based on EPPM.MethodsIn this cross‐sectional study, 699 personnel of the deputy health department of Chaharmahal and Bakhtiari province were included in the study by census method. Data were collected online using valid questionnaires, including demographic questions and history of contracting COVID‐19 and the questionnaire of EPPM constructs. Data were analyzed in SPSS24 software, using descriptive and analytical statistics.ResultsThe results showed that there were positive correlations between the protective behaviors and the constructs of perceived severity (p < 0.001, r = 0.542), perceived susceptibility (p < 0.001, r = 0.260), self‐efficacy (p < 0.001, r = 0.594), response efficiency (p > 0.001, r = 0.522), and risk control (p > 0.001, r = 0.501). There was a negative correlation between protective behaviors and fear control (p < 0.001, r = 0.329). The results of multiple linear regression showed that these six constructs explained 49.8% of protective behaviors against COVID‐19, among which the role of the perceived severity construct was stronger than other constructs.ConclusionRegarding the results, it is suggested that the results of this research be used in the development of training programs to improve protective behaviors in high‐traffic offices, and by focusing on fear and risk control.
Constructal design of crossflow heat exchanger with concentric and eccentric circular fins
Authors: Mustafa Ahmed Waheed , Sulaiman Usama Abdullah , Awad Mohamed M. 
Published: December 2023

AbstractA single‐row crossflow heat exchanger with concentric and eccentric circular fins is designed and shown in this paper using a constructal design approach. The transverse fins spacing, the spanwise fins spacing, and the fin‐tube eccentricity are varied inside a fixed volume. In addition to the concentric case (ε = 0), two tube‐fin eccentricities are considered with (ε = ±0.25). The (heat transfer/volume) heat density is to be optimized with respect to the transverse and the spanwise spacing. The height and the width of the heat exchanger occupation space in addition to the fin diameter are fixed as design constraints. The crossflow is motivated by constant pressure drop with two dimensionless pressure drop numbers (Bejan number) (Be = 103 and 105). Both the fins and the tubes are maintained at a constant temperature, and they are cooled by the cross air of ambient temperature. The ratio of the fin to tube diameter is kept at 0.5. Three‐dimensional equations for conservation of mass, conservation of momentum, and conservation of energy are solved using finite volume method for incompressible and steady flows. The heat density for concentric fins (ε = 0) and eccentric fins (ε = ±0.25) is maximized two times, one with respect to transverse spacing, and the other with respect to spanwise spacing at Bejan numbers (Be = 103 and 105). The highest double‐maximized heat density is attained at the fin eccentricity (ε = 0.25). The increase in the double maximized heat density when the fin eccentricity (ε = 0.25) is 7.65% for Be = 103, and it is 12% for Be = 105.
Your gender identity is who you are: Female chief executive officers and corporate debt structure
Authors: Huang Yuxuan , Zhu Qi , Yan Cheng , Zeng Yeqin 
Published: December 2023

AbstractUsing a large sample of S&P 1500 firms during 1993–2021, we empirically examine the implications of CEO gender on corporate debt structure. We find that after controlling for endogeneity, firms managed by female CEOs issue less debt than those managed by male CEOs. Female CEOs being more risk averse than male CEOs is the underlying mechanism which drives the negative relation between female CEOs and firm leverage. Further, we find that the effect of CEO gender is more pronounced when the firm's CEO is younger, the litigation risk is higher, and the market is more competitive. In terms of debt structure, firms managed by female CEOs prefer to maintain positive debt capacity and have longer debt maturities. Finally, we show that CEO gender has a stronger impact on debt structure than CFO gender. Taken together, our evidence suggests that there exist gender differences in terms of corporate debt borrowing decision making.
Periselectivity and ambimodal transition states in cycloadditions of tetrachloro‐o‐benzoquinone with 6,6‐dimethylfulvene
Authors: Su Ruirui , He Xue , Houk K. N. , Lu Qianqian , Liu Fang 
Published: December 2023

AbstractThe reaction mechanism of cycloadditions of tetrachloro‐o‐benzoquinone with 6,6‐dimethylfulvene were systematically investigated with density functional theory calculations. It was found that conditional primary interactions stabilize the ambimodal transition states in the endo pathways. Ambimodal transition states lead to [6 + 4]/[4 + 2] adducts or [4 + 2]/[2 + 4] adducts, which interconvert through 3,3‐sigmatropic shift reactions. The substituent effects on periselectivity were also investigated.
Sporadic simple groups as flag‐transitive automorphism groups of symmetric designs
Authors: Alavi Seyed Hassan , Daneshkhah Ashraf 
Published: December 2023

AbstractIn this article, we study symmetric designs admitting flag‐transitive, point‐imprimitive almost simple automorphism groups with socle sporadic simple groups. As a corollary, we present a classification of symmetric designs admitting flag‐transitive automorphism group whose socle is a sporadic simple group, and in conclusion, there are exactly seven such designs, one of which admits a point‐imprimitive automorphism group and the remaining are point‐primitive.
The use of carbon spheres to enhance the beneficial activity of Bacillus thuringiensis and Micromonospora echinospora in the germination of Prosopis glandulosa
Authors: la Cruz Juan Luis Ignacio‐De , Granados‐Martínez Francisco Gabriel , Sánchez‐Yañez Juan Manuel , la Cruz David Ricardo Poiré‐De , Flores‐Ramírez Nelly , Hernández‐Cristóbal Orlando , Domratcheva‐Lvova Lada 
Published: December 2023

AbstractBACKGROUNDThe synthesis of carbon nanomaterials such as carbon spheres (CSs) can be based on the use of renewable, inexpensive and accessible precursors through an effective, simple and rapid technique. The application of CSs can be used as an option to enhance the biological activity of beneficial endophytic microorganisms to promote the growth of forest plants such as Prosopis glandulosa (mesquite). The aim of this study was to analyze the response of P. glandulosa to Bacillus thuringiensis and Micromonospora echinospora with 50% fertilizer solution (FES) enhanced with CSs.RESULTSThe synthesized nanomaterials were characterized by microscopic and spectroscopic techniques showing CSs with 250–500 nm diameters with the presence of functional groups such as OH, CO and CC. P. glandulosa seeds inoculated with B. thuringiensis/M. echinospora with FES containing CSs emerged after 6 days with 100% germination in comparison with 62% germination in 13 days with absolute control.CONCLUSIONP. glandulosa treated with B. thuringiensis and M. echinospora and FES improved with 10 and 20 ppm of CSs had a positive response in terms of emergence days and percentage germination. © 2023 Society of Chemical Industry (SCI).
Preoperative Gadoxetic Acid‐Enhanced MRI Features for Evaluation of Vessels Encapsulating Tumor Clusters and Microvascular Invasion in Hepatocellular Carcinoma: Creating Nomograms for Risk Assessment
Authors: Qu Qi , Liu Zixin , Lu Mengtian , Xu Lei , Zhang Jiyun , Liu Maotong , Jiang Jifeng , Gu Chunyan , Ma Qinrong , Huang Aina , Zhang Xueqin , Zhang Tao 
Published: December 2023

BackgroundVessels encapsulating tumor cluster (VETC) and microvascular invasion (MVI) have a synergistic effect on prognosis assessment and treatment selection of hepatocellular carcinoma (HCC). Preoperative noninvasive evaluation of VETC and MVI is important.PurposeTo explore the diagnosis value of preoperative gadoxetic acid (GA)‐enhanced magnetic resonance imaging (MRI) features for MVI, VETC, and recurrence‐free survival (RFS) in HCC.Study TypeRetrospective.Population240 post‐surgery patients with 274 pathologically confirmed HCC (allocated to training and validation cohorts with a 7:3 ratio) and available tumor marker data from August 2014 to December 2021.Field Strength/Sequence3‐T, T1‐, T2‐, diffusion‐weighted imaging, in/out‐phase imaging, and dynamic contrast‐enhanced imaging.AssessmentThree radiologists subjectively reviewed preoperative MRI, evaluated clinical and conventional imaging features associated with MVI+, VETC+, and MVI+/VETC+ HCC. Regression‐based nomograms were developed for HCC in the training cohort. Based on the nomograms, the RFS prognostic stratification system was further. Follow‐up occurred every 3–6 months.Statistical TestsChi‐squared test or Fisher's exact test, Mann–Whitney U‐test or t‐test, least absolute shrinkage and selection operator–penalized, multivariable logistic regression analyses, receiver operating characteristic analysis, Harrell's concordance index (C‐index), Kaplan–Meier plots. Significance level: P < 0.05.ResultsIn the training group, 44 patients with MVI+ and 74 patients with VETC+ were histologically confirmed. Three nomograms showed good performance in the training (C‐indices: MVI+ vs. VETC+ vs. MVI+/VETC+, 0.892 vs. 0.848 vs. 0.910) and validation (C‐indices: MVI+ vs. VETC+ vs. MVI+/VETC+, 0.839 vs. 0.810 vs. 0.855) cohorts. The median follow‐up duration for the training cohort was 43.6 (95% CI, 35.0–52.2) months and 25.8 (95% CI, 16.1–35.6) months for the validation cohort. Patients with either pathologically confirmed or nomogram‐estimated MVI, VETC, and MVI+/VETC+ suffered higher risk of recurrence.Data ConclusionGA‐enhanced MRI and clinical variables might assist in preoperative estimation of MVI, VETC, and MVI+/VETC+ in HCC.Evidence Level4Technical EfficacyStage 2