bluuebunny/crossref_metadata_2025_split huggingface dataset:
Senescence Targeting Methods Impact Alzheimer’s Disease Features in 3xTg Mice
Authors: Ng Pei Y. , Zhang Cheng , Li Hu , Baker Darren J. 
Published: January 2024

Background: Cellular senescence has been associated with neurodegenerative disease and clearance of senescent cells using genetic or pharmaceutical strategies (senolytics) has demonstrated beneficial effects in mouse models investigating individual disease etiologies of Alzheimer’s disease (AD). However, it has remained unclear if senescent cell clearance in a mouse model exhibiting both plaque and tau pathologies modifies the disease state (3xTg). Objective: To investigate the effects of senescent cell clearance in the 3xTg mouse model. Methods: 3xTg mice were treated with senolytics (ABT263 (navitoclax; NAVI), a combination of dasatinib and quercetin (D+Q)), or subjected to transgene-mediated removal of p16-expressing cells (via INK-ATTAC). Results: Senolytic treatments consistently reduced microgliosis and ameliorated both amyloid and tau pathology in 3xTg mice. Using RNA sequencing, we found evidence that synaptic dysfunction and neuroinflammation were attenuated with treatment. These beneficial effects were not observed with short-term senolytic treatment in mice with more advanced disease. Conclusions: Overall, our results further corroborate the beneficial effects senescent cell clearance could have on AD and highlight the importance of early intervention for the treatment of this debilitating disease.
Transcranial random noise stimulation to augment hand function in individuals with moderate-to-severe stroke: A pilot randomized clinical trial
Authors: Sethi Amit , Pascual-Leone Alvaro , Santarnecchi Emiliano , Almalki Ghaleb , Krishnan Chandramouli 
Published: January 2024

Background: Interventions to recover upper extremity (UE) function after moderate-to-severe stroke are limited. Transcranial random noise stimulation (tRNS) is an emerging non-invasive technique to improve neuronal plasticity and may potentially augment functional outcomes when combined with existing interventions, such as functional electrical stimulation (FES). Objective: The objective of this study was to investigate the feasibility and preliminary efficacy of combined tRNS and FES-facilitated task practice to improve UE impairment and function after moderate-to-severe stroke. Methods: Fourteen individuals with UE weakness were randomized into one of two groups: 1) tRNS with FES-facilitated task practice, or 2) sham-tRNS with FES-facilitated task practice. Both groups involved 18 intervention sessions (3 per week for 6 weeks). tRNS was delivered at 2 mA current between 100–500 Hz for the first 30 minutes of FES-facilitated task practice. We evaluated the number of sessions completed, adverse effects, participant satisfaction, and intervention fidelity between the two therapists. UE impairment (Fugl-Meyer Upper Extremity, FMUE), function (Wolf Motor Function Test, WMFT), participation (Stroke Impact Scale hand score, SIS-H), and grip strength were assessed at baseline, within 1 week and 3 months after completing the intervention. Results: All participants completed the 18 intervention sessions. Participants reported minimal adverse effects (mild tingling in head). The two trained therapists demonstrated 93% adherence and 96% competency with the intervention protocol. FMUE and SIS-H improved significantly more in the tRNS group than in the sham-tRNS group at both timepoints ( p≤0.05), and the differences observed exceeded the clinically meaningful differences for these scores. The WMFT and paretic hand grip strength improved in both groups after the intervention ( p≤0.05), with no significant between group differences. Conclusion: Our findings show for the first time that combining tRNS and FES-facilitated task practice is a feasible and promising approach to improve UE impairment and function after moderate-to-severe stroke.
State primary standard of the unit of overpressure in the range of static pressure from 10 to 1600 MPa and in the range of impulse pressure
Authors: Gavrilkin S. M. , Borovkov V. M. , Aslanyan A. E. , Temnitskii I. N. , Fedorov A. O. , Yurov L. V. , Aslanyan E. G. , Shvydun V. V. , Shchipunov A. N. 
Published: January 2024

The necessity and relevance of precision pulse pressure measurements in industry (high-speed technological processes) and transport (existing and new types of engines) is shown. The device, the principle of operation and the result of metrological studies of the State Primary Standard of the unit of overpressure in the range of static pressure from 10 to 1600 MPa and in the range of pulse pressure from 1 to 1200 MPa and the effective area of piston pairs of piston pressure gauges in the range from 0.05 to 1 cm2 GET 43-2022 are presented. The GET 43-2022 includes hydraulic and pneumatic installations, as well as an ultra-high pressure valve designed to compare installations from the GET 43-2022 composition working with different standard fl uids in the range of 250-1200 MPa. The reproduction range of the pulse pressure unit GET 43-2022 is 1-1200 MPa. The method of reproducing the pulse pressure unit in liquid and gas media using hydraulic and pneumatic installations is described. The metrological characteristics of GET 43-2022 are investigated, the budget of measurement uncertainty is calculated when reproducing the pulse pressure unit. The results obtained make it possible to meet the needs of the development of a fl eet of working standards for pulse pressure measuring instruments traceable to GET 43-2022.
CFD Analysis on HVAC System Functionality in an Amphitheater
Authors: Rahman M M , Hasan M M 
Published: January 2024

Heating, Ventilation and Air conditioning (HVAC) is an important part of residential structures such as single-family homes, apartment buildings, hotels and medium to large industrial and office buildings such as skyscrapers and hospitals, on ships, submarines and in marine environments.This paper investigates the characteristics of the performance HVAC system at “KUET auditorium” regarded as amphitheater for various internal and external conditions. A 2D model of the longitudinal section of the auditorium was drawn by using ANSYS-Fluent software in Design Modeler, for simulating the various functionality of the HVAC system for both summer & winter seasons. In this research, both the indoor & external conditions of KUET auditorium were considered, having the entire spectacle of hall is occupied by people. The main aim of this study was to observe the air temperature, air velocity and relative humidity for each case. The results are represented comparatively as graphs and spectra for various mass flow rates and indoor-outdoor temperatures. It was observed that the HVAC system provided sufficient human comfort conditions in terms of air flow and relative humidty recommended by (American Society of Heating, Refrigerating and Air Conditioing Engineers) AHRAE in the amphitheater for both the summer and winter season.
Journal of Engineering Science 14(2), 2023, 01-14
Factors Relating to Patient Safety Competencies in D3 Nursing Students
Authors: Linda Silvana Evi 
Published: January 2024

Aims: This research to identify factors related to competency regarding patient safety among D3 nursing students in Jakarta.
Methods: This research will use a cross-sectional design. The research will be carried out at the nursing academy in Jakarta. The sample in this study were level 3 D3 nursing students. The questionnaire was used to measure patient safety competency, knowledge and attitudes. Data analysis was carried out using linear regression techniques.
Results: The study reveals that D3 nursing students have a strong patient safety competency score, with a moderate positive correlation between knowledge and competency. Attitudes also play a significant role, with a positive correlation of 91.9%. Age and education influence attitudes, affecting compliance.
Conclusions: Attitude variable significantly influences patient safety competency in D3 nursing students, indicating the need for comprehensive research and increased education to enhance clinical safety.
Instant Creativity or the Sounding Line of Life
Authors: Villavicencio Cesar 
Published: January 2024

Entrevista com Richard Barrett.

Por: César Marino Villavicencio Grossmann
Pesquisador Colaborador, Escola de Ciências, Artes e Humanidade, USP.

A entrevista com o compositor e improvisador galês Richard Barrett busca explorar a sua multifacetada experiência nos campos da música, educação, filosofia e política. De fato, o pensamento de Barrett nos rende uma rica dimensão composta por um amplo poder criativo que reúne todos esses campos em seu pensamento e criações artísticas. Particularmente interessante para o presente dossiê da revista Mosaico é sua visão da improvisação como um método de composição no lugar de uma forma oposta de criação musical formal. Também, a entrevista visa trazer à luz o multifacetado pensamento de Barrett sobre a improvisação livre, como por exemplo, a iniciativa expressa em seu recente livro intitulado Music of Possibility que revela caminhos intermediários entre a composição notada e a improvisação livre, referida por ele como “seeded improvisation”. No aspecto da educação, Richard revela o impacto de suas ousadas iniciativas no Real Conservatório de Haia, Holanda, que propõem uma gradativa dissolução da divisão curricular da instituição em diferentes departamentos. Como linha da vida desta entrevista, teremos a constate e pulsante preocupação do compositor com a situação política e social mundial e sua visão de como isto influencia a sociedade e arte de forma geral.
Identity capital and future concerns in urban adolescents from La Araucanía-Chile
Authors: Neira-Escalona Yosyua , Bravo-Sanzana Mónica , Terán-Mendoza Oscar , Miranda Rafael 
Published: January 2024

IntroductionLate modernity influences the construction and constitution of identity and the management of adolescents’ future lives. Research has shown that identity capital predicts the resolution of a successful identity; however, in Latin America, no antecedents have conducted studies under this conceptual framework.AimTo analyze the relationship pattern between identity capital components and future concerns.MethodsThe participants were 703 adolescents between the ages of 15 and 19 years who, in the year 2021, were in the third and fourth years of high school in urban educational establishments in La Araucanía Chile, to whom questions from the Governance of Educational Trajectories in Europe (GOETE) adapted to the Chilean context and the general self-efficacy scale were applied. Confirmatory Factor Analyses (CFA) were performed to determine the suitability of the indicators to measure the constructs of interest and a structural equation analysis to determine the pattern of relationships between variables.ResultsThe final model obtained excellent indicators of the goodness of fit [χ2 (422) = 965.858, p &lt; 0.001; CFI = 0.977; TLI = 0.975; RMSEA = 0.043; SRMR = 0.056], in which it is evident that parental support and interaction are related to self-efficacy and self-concept and these, in turn, is associated with adolescents’ future concerns.ConclusionThe relationship pattern tested shows that associations between tangible elements at the family level are related to intangible aspects of a personal nature, which can be protective factors against future concerns, and provide empirical support for the psychometric usefulness of the GOETE indicators in the Chilean context.
Application opportunity of Doppler ultrasound combined with CT angiography in diabetic lower extremity arterial disease and the analysis of the risk factors
Authors: Zhang ShaoRui , Wu Yan , Guo YuQing , Jia XinJu , Kang Yan , Shen XueLian , Song Jia , Yang AiGe 
Published: January 2024

ObjectiveThis study examined the potential of combining Doppler ultrasound (DUS) and CT angiography (CTA) for early detection and intervention of lower extremity arterial disease (LEAD) in diabetes.Concurrently, risk factors influencing LEAD progression were analyzed.Methods106 Type-2 diabetes patients with LEAD, having undergone DUS and CTA, were divided into four stages according to Fontaine stage. Results of DUS and CTA were compared across stages and potential risk factors were analyzed.ResultsPositive detection rates of LEAD differed between DUS and CTA for Fontaine stages I and II (P &lt; 0.05), with no significant difference for stages III and IV (P &gt; 0.05). CTA identified subgroups with mild to moderate stenosis and severe stenosis or occlusion, with positive rates on DUS of 17.95% and 89.9% respectively. Hypertension was found as an independent risk factor affecting LEAD progression.ConclusionCTA should be performed early for LEAD in diabetes patients at Fontaine stages I and II, regardless of DUS results. For diabetes patients with LEAD, stringent blood pressure control is crucial to delay disease progression.
Relationship of the bone phenotype of the Klotho mutant mouse model of accelerated aging to changes in skeletal architecture that occur with chronological aging
Authors: Verlinden Lieve , Li Shanshan , Veldurthy Vaishali , Carmeliet Geert , Christakos Sylvia 
Published: January 2024

IntroductionDue to the relatively long life span of rodent models, in order to expediate the identification of novel therapeutics of age related diseases, mouse models of accelerated aging have been developed. In this study we examined skeletal changes in the male and female Klotho mutant (kl/kl) mice and in male and female chronically aged mice to determine whether the accelerated aging bone phenotype of the kl/kl mouse reflects changes in skeletal architecture that occur with chronological aging.Methods2, 6 and 20-23 month old C57BL/6 mice were obtained from the National Institute of Aging aged rodent colony and wildtype and kl/kl mice were generated as previously described by M. Kuro-o. Microcomputed tomography analysis was performed ex vivo to examine trabecular and cortical parameters from the proximal metaphyseal and mid-diaphyseal areas, respectively. Serum calcium and phosphate were analyzed using a colorimetric assay. The expression of duodenal Trpv6, which codes for TRPV6, a vitamin D regulated epithelial calcium channel whose expression reflects intestinal calcium absorptive efficiency, was analyzed by quantitative real-time PCR.Results and discussionTrabecular bone volume (BV/TV) and trabecular number decreased continuously with age in males and females. In contrast to aging mice, an increase in trabecular bone volume and trabecular number was observed in both male and female kl/kl mice. Cortical thickness decreased with advancing age and also decreased in male and female kl/kl mice. Serum calcium and phosphate levels were significantly increased in kl/kl mice but did not change with age. Aging resulted in a decline in Trpv6 expression. In the kl/kl mice duodenal Trpv6 was significantly increased. Our findings reflect differences in bone architecture as well as differences in calcium and phosphate homeostasis and expression of Trpv6 between the kl/kl mutant mouse model of accelerated aging and chronological aging. Although the Klotho deficient mouse has provided a new understanding of the regulation of mineral homeostasis and bone metabolism, our findings suggest that changes in bone architecture in the kl/kl mouse reflect in part systemic disturbances that differ from pathophysiological changes that occur with age including dysregulation of calcium homeostasis that contributes to age related bone loss.
Evaluation of neoadjuvant immunotherapy in resectable gastric/gastroesophageal junction tumors: a meta-analysis and systematic review
Authors: Wang Jincheng , Tong Ti , Zhang Guangxin , Jin Chengyan , Guo Haiping , Liu Xueying , Zhang Zhengxiao , Li Jindong , Zhao Yinghao 
Published: January 2024

BackgroundNeoadjuvant therapy for resectable gastric cancer/gastroesophageal junction tumors is progressing slowly. Although immunotherapy for advanced gastric cancer/gastroesophageal junction tumors has made great progress, the efficacy and safety of neoadjuvant immunotherapy for locally resectable gastric cancer/gastroesophageal junction tumors have not been clearly demonstrated. Here, we conducted a systematic review and meta-analysis to assess the efficacy and safety of neoadjuvant immunotherapy and advance the current research.MethodsOriginal articles describing the safety and efficacy of neoadjuvant immunotherapy for resectable gastric cancer/gastroesophageal junction tumors published up until October 15, 2023 were retrieved from PubMed, Embase, the Cochrane Library, and other major databases. The odds ratios (OR) and 95% confidence intervals (CIs) were calculated for heterogeneity and subgroup analysis.ResultsA total of 1074 patients from 33 studies were included. The effectiveness of neoadjuvant immunotherapy was mainly evaluated using pathological complete remission (PCR), major pathological remission (MPR), and tumor regression grade (TRG). Among the included patients, 1015 underwent surgical treatment and 847 achieved R0 resection. Of the patients treated with neoadjuvant immunotherapy, 24% (95% CI: 19%–28%) achieved PCR and 49% (95% CI: 38%–61%) achieved MPR. Safety was assessed by a surgical resection rate of 0.89 (95% CI: 85%–93%), incidence of ≥ 3 treatment-related adverse events (TRAEs) of 28% (95% CI: 17%–40%), and incidence of ≥ 3 immune-related adverse events (irAEs) of 19% (95% CI: 11%–27%).ConclusionNeoadjuvant immunotherapy, especially neoadjuvant dual-immunotherapy combinations, is effective and safe for resectable gastric/gastroesophageal junction tumors in the short term. Nevertheless, further multicenter randomized trials are required to demonstrate which combination model is more beneficial.Systematic review registrationhttps://www.crd.york.ac.uk/PROSPERO/display_record.php?RecordID=358752, identifier CRD42022358752.
High ANO1 expression is a prognostic factor and correlated with an immunosuppressive tumor microenvironment in pancreatic cancer
Authors: Zhang Guangnian , Shu Zhihui , Yu Jun , Li Jianshui , Yi Pengsheng , Wu Bin , Deng Dawei , Yan Shu , Li Yong , Ren Dongmei , Hou Yifu , Lan Chuan 
Published: January 2024

BackgroundAminooctylamine (ANO1) plays an oncogenic role in various cancers. However. its role in pancreatic cancer (PC) has rarely been studied. This study investigated the prognostic value of ANO1 and its correlation with the tumor microenvironment (TME) in PC.MethodsConsecutive patients with PC (n = 119) were enrolled. The expression of ANO1 in cancer cells, the expression of fibroblast activation protein (FAP) and alpha smooth muscle actin in cancer-associated fibroblasts (CAFs), and the numbers of CD8- and FOXP3-positive tumor-infiltrating lymphocytes (TILs) were evaluated using immunohistochemistry. The prognostic value of ANO1 and its correlation with CAF subgroups and TILs were analyzed. The possible mechanism of ANO1 in the TME of PC was predicted using the the Cancer Genome Atlas (TCGA) dataset.ResultsThe expression of AN01 was correlated with overall survival (OS) and disease-free survival. Multi-factor analysis showed that high ANO1 expression was an independent adverse prognostic factor for OS (hazard ratio, 4.137; P = 0.001). ANO1 expression was positively correlated with the expression of FAP in CAFs (P &lt; 0.001) and negatively correlated with the number of CD8-positive TILs (P = 0.005), which was also validated by bioinformatics analysis in the TCGA dataset. Moreover, bioinformatic analysis of the TCGA dataset revealed that ANO1 may induce an immunosuppressive tumor microenvironment in pancreatic cancer in a paracrine manner.ConclusionANO1 is a prognostic factor in patients with PC after radical resection. ANO1 may induce an immunosuppressive tumor microenvironment in PC in a paracrine manner, suggesting that ANO1 may be a novel therapeutic target.
Satisfaction with health care services in young people with cerebral palsy in the transition period: results from a European multicenter study
Authors: Muehlan Holger , Alvarelhao Joaquim , Arnaud Catherine , Cytera Chirine , Fauconnier Jerome , Himmelmann Kate , Marcelli Marco , Markwart Henriette , Rapp Marion , Schmidt Silke , Thyen Ute 
Published: January 2024

BackgroundYoung people with chronic health conditions and disabilities rely on the healthcare system to maintain their best possible health. The appropriate delivery and utilization of healthcare services are key to improve their autonomy, self-efficacy and employment outcomes. The research question of our study is directed toward investigating if poor availability and accessibility of healthcare services in general, as identified by unmet needs in healthcare, are associated with dissatisfaction with healthcare.MethodsWithin a European multicenter observational study, 357 young adults with cerebral palsy aged 19–28 were included. We assessed special healthcare needs, utilization of healthcare services, and satisfaction with healthcare applying the short-form of the YHC-SUN-SF, environmental and social variables (EAEQ) as well as indicators for severity of condition and functionality (e.g., GMFCS) of these participants based on a self-, assisted self- or proxy-reports. We used correlation analyses to explore associations between satisfaction with healthcare and respective indicators related to availability and accessibility of healthcare services as well as severity of the condition. In addition, we included reference values for satisfaction with heath care from young adults with various chronic conditions assessed within population-based surveys from some of the European countries included in the study.ResultsWe identified several unmet healthcare needs, especially for widely used and established services (e.g., physical therapy). Satisfaction with healthcare (YHC-SUN-SF general and subscale scores) was moderate to high and almost consistently better for the sample of young adults with cerebral palsy as compared to reference values for young adults with various chronic conditions assessed within general population surveys). Correlation coefficients between satisfaction with healthcare and utilization of services and (unmet) healthcare needs were low, also with different indicators for severity of the condition or functionality.ConclusionYoung adults with cerebral palsy reports of unmet healthcare needs varied largely but showed substantial deficits in some aspects. This seems to have no impact on the satisfaction with healthcare those patients currently receive. We conclude that these are two different constructs and somewhat independent indicators to evaluate the quality of healthcare. Clinicians and other practitioners should consider this distinction when monitoring patient needs in their daily practice.