bluuebunny/crossref_metadata_2025_split huggingface dataset:
Variability of mpMRI diagnostic performance according to the upfront individual patient risk of having clinically significant prostate cancer
Authors: Pellegrino Francesco , Stabile Armando , Sorce Gabriele , Mazzone Elio , Cannoletta Donato , Cirulli Giuseppe Ottone , Quarta Leonardo , Leni Riccardo , Robesti Daniele , Brembilla Giorgio , Gandaglia Giorgio , De Cobelli Francesco , Montorsi Francesco , Briganti Alberto 
Published: December 2023

AbstractBackgroundTo assess the variation of multiparametric magnetic resonance imaging (mpMRI) positive predictive value (PPV) according to each patient's risk of clinically significant prostate cancer (csPCa) based exclusively on clinical factors.MethodsWe evaluated 999 patients with positive mpMRI (PI‐RADS ≥ 3) receiving targeted (TBx) plus systematic prostate biopsy. We built a multivariable logistic regression analysis (MVA) using clinical risk factors to calculate the individual patients' risk of harboring csPCa at TBx. A second MVA tested the association between individual patients' clinical risk and mpMRI PPV accounting for the PI‐RADS score. Finally, we plotted the PPV of each PI‐RADS score by the individual patient pretest probability of csPCa using a LOWESS approach.ResultsOverall, TBx found csPCa in 21%, 51%, and 80% of patients with PI‐RADS 3, 4, and 5 lesions, respectively. At MVA, age, PSA, digital rectal examination (DRE), and prostate volume were significantly associated with the risk of csPCa at biopsy. DRE yielded the highest odds ratio (OR: 2.88; p < 0.001). The individual patient's clinical risk was significantly associated with mpMRI PPV (OR: 2.49; p < 0.001) using MVA. Plotting the mpMRI PPV according to the predicted clinical risks, we observed that for patients with clinical risk close to 0 versus patients with risk higher than 90%, the mpMRI PPV of PI‐RADS 3, 4, and 5 ranged from 0% to 75%, from 0% to 96%, and from 45% to 100%, respectively.ConclusionmpMRI PPV varies according to the individual pretest patient's risk based on clinical factors. These findings should be considered in the decision‐making process for patients with suspect MRI findings referred for a prostate biopsy. Moreover, our data support the need for further studies to create an individualized risk prediction tool.
Clinical considerations on monkeypox antiviral medications: An overview
Authors: Pourkarim Fariba , Entezari‐Maleki Taher 
Published: December 2023

AbstractMonkeypox (mpox), a virus belonging to the orthopoxvirus family, can cause a zoonotic infectious disease with morbidity and cosmetic complications. Therefore, effective antiviral drugs with appropriate safety profiles are important for the treatment of patients with mpox. To date, there is no FDA‐approved drug for the treatment of mpox. However, tecovirimat, brincidofovir, and cidofovir are the candidate therapies for the management of mpox. Given the safety concerns following the use of these medications, we aimed to review evidence on the clinical considerations of mpox antiviral medications that will be useful to guide clinicians in the treatment approach. Based on the current evidence, tecovirimat has favorable clinical efficacy, safety, and side effect profile and it can be considered as first‐line treatment for mpox.
Utilization of perforated zipper‐lock packaging bags to improve the quality of stem‐on and stem‐free ‘Chelan’ and ‘Lapins’ sweet cherries during the storage and marketing periods
Authors: Zhi Huanhuan , Dai Huimin , Leisso Rachel , Dong Yu 
Published: December 2023

AbstractIn the current domestic market, improper packaging systems cause a significant amount of food loss and waste of sweet cherry fruit from the packinghouse to the table. The purpose of this study was to assess whether reducing the commercial zipper‐lock bags' perforation ratio (PR) from 2% to 0.5% or 0.05% had the potential to improve the quality and resistance to postharvest disorders of stem‐on (SO) and stem‐free (SF) ‘Chelan’ and ‘Lapins’ cherries during a series of 14 days at 0°C, 2 days at 10°C and 2 days at 20°C (the storage and marketing periods). Regardless of whether the stem was attached to the fruit, reducing PR from 2% to 0.5% or 0.05% resulted in a high relative humidity, an increased CO2 with a decreased O2 in bags and reduced weight loss of fruit and stems in both cultivars during the entire storage and marketing periods; furthermore, higher fruit firmness, skin brightness and stem green color with lower rates of surface pitting and stem browning and relative leakage of stems were observed in either SO or SF of ‘Chelan’ and ‘Lapins’ cherries packaged with 0.5% and 0.05% PR bags compared to 100 (air) and 2% PR‐treated cherries. However, the 0.05% PR packaging system retained a significant amount of condensation water in the bag; as a result, the decay incidence of SF cherries statistically increased. Overall, packing SO and SF ‘Chelan’ and ‘Lapins’ cherries in bags with a 0.5% PR provided great benefits in delaying weight loss and pathogen infection and maintaining the high eating and storage quality during the storage and marketing periods.
Evaluating fluvoxamine for the outpatient treatment of COVID‐19: A systematic review and meta‐analysis
Authors: Deng Jiawen , Moskalyk Myron , Zuo Qi Kang , Garcia Cristian , Abbas Umaima , Ramaraju Harikrishnaa Ba , Rayner Daniel , Park Ye‐Jean , Heybati Kiyan , Zhou Fangwen , Lohit Simran 
Published: December 2023

AbstractThis systematic review and meta‐analysis of randomised controlled trials (RCTs) aimed to evaluate the efficacy, safety, and tolerability of fluvoxamine for the outpatient management of COVID‐19. We conducted this review in accordance with the PRISMA 2020 guidelines. Literature searches were conducted in MEDLINE, EMBASE, International Pharmaceutical Abstracts, CINAHL, Web of Science, and CENTRAL up to 14 September 2023. Outcomes included incidence of hospitalisation, healthcare utilization (emergency room visits and/or hospitalisation), mortality, supplemental oxygen and mechanical ventilation requirements, serious adverse events (SAEs) and non‐adherence. Fluvoxamine 100 mg twice a day was associated with reductions in the risk of hospitalisation (risk ratio [RR] 0.75, 95% confidence interval [CI] 0.58–0.97; I
2 = 0%) and reductions in the risk of healthcare utilization (RR 0.68, 95% CI 0.53–0.86; I
2 = 0%). While no increased SAEs were observed, fluvoxamine 100 mg twice a day was associated with higher treatment non‐adherence compared to placebo (RR 1.61, 95% CI 1.22–2.14; I
2 = 53%). In subgroup analyses, fluvoxamine reduced healthcare utilization in outpatients with BMI ≥30 kg/m2, but not in those with lower BMIs. While fluvoxamine offers potential benefits in reducing healthcare utilization, its efficacy may be most pronounced in high‐risk patient populations. The observed non‐adherence rates highlight the need for better patient education and counselling. Future investigations should reassess trial endpoints to include outcomes relating to post‐COVID sequelaes. Registration: This review was prospectively registered on PROSPERO (CRD42023463829).
Connectivity‐preserving consensus: An adaptive event‐triggered strategy
Authors: Guo Tiantian , Liu Yungang 
Published: December 2023

SummaryThe connectivity of communication graph is indispensable for consensus of multi‐agent systems (MASs), which in many applications (e.g., wireless sensor) depends on the relative distances between agents. But, in the adaptive setting particularly with system nonlinearities and event‐triggered communication, it is rather difficult to enforce the relative distances within the limited range for the connectivity. This paper focuses on developing an adaptive event‐triggered control strategy with connectivity preservation in the context of nonidentical unknown control coefficients and heterogeneous nonlinearities coupling with parameter uncertainties. First, a group of potential functions are introduced acting as control barrier functions to constrain the relative distances between agents within the limited range for all time. Also, two dynamic gains are specialized for each agent to handle the system uncertainties, system nonlinearities and negative effect of the execution error. Then, an adaptive event‐triggered protocol is designed for each agent such that the connectivity‐preserving consensus of MASs is achieved and Zeno behavior is excluded. Moreover, an extended study is conducted on a leader‐following scenario. Two simulation examples illustrate the effectiveness of the proposed event‐triggered control strategy.
Advanced High‐Energy All‐Solid‐State Hybrid Supercapacitor with Nickel‐Cobalt‐Layered Double Hydroxide Nanoflowers Supported on Jute Stick‐Derived Activated Carbon Nanosheets
Authors: Shah Syed Shaheen , Aziz Md. Abdul , Ali Muhammad , Hakeem Abbas Saeed , Yamani Zain H. 
Published: December 2023

AbstractDeveloping efficient, lightweight, and durable all‐solid‐state supercapacitors is crucial for future energy storage systems. The study focuses on optimizing electrode materials to achieve high capacitance and stability. This study introduces a novel two‐step pyrolysis process to synthesize activated carbon nanosheets from jute sticks (JAC), resulting in an optimized JAC‐2 material with a high yield (≈24%) and specific surface area (≈2600 m2 g−1). Furthermore, an innovative in situ synthesis approach is employed to synthesize hybrid nanocomposites (NiCoLDH‐1@JAC‐2) by integrating JAC nanosheets with nickel‐cobalt‐layered double hydroxide nanoflowers (NiCoLDH). These nanocomposites serve as positive electrode materials and JAC‐2 as the negative electrode material in all‐solid‐state asymmetric hybrid supercapacitors (HSCs), exhibiting remarkable performance metrics. The HSCs achieve a specific capacitance of 750 F g−1, a specific capacity of 209 mAh g−1 (at 0.5 A g−1), and an energy density of 100 Wh kg−1 (at 250 W kg−1) using PVA/KOH solid electrolyte, while maintaining outstanding cyclic stability. Importantly, a density functional theory framework is utilized to validate the experimental findings, underscoring the potential of this novel approach for enhancing HSC performance and enabling the large‐scale production of transition metal‐based layered double hydroxides.
Ligand Defect‐Induced Active Sites in Ni‐MOF‐74 for Efficient Photocatalytic CO2 Reduction to CO
Authors: Dong Yong‐Li , Jiang Yu , Ni Shuang , Guan Guo‐Wei , Zheng Su‐Tao , Guan Qingqing , Pei Ling‐Min , Yang Qing‐Yuan 
Published: December 2023

AbstractThe conversion of CO2 into valuable carbon‐based products using clean and renewable solar energy has been a significant challenge in photocatalysis. It is of paramount importance to develop efficient photocatalysts for the catalytic conversion of CO2 using visible light. In this study, the Ni‐MOF‐74 material is successfully modified to achieve a highly porous structure (Ni‐74‐Am) through temperature and solvent modulation. Compared to the original Ni‐MOF‐74, Ni‐74‐Am contains more unsaturated Ni active sites resulting from defects, thereby enhancing the performance of CO2 photocatalytic conversion. Remarkably, Ni‐74‐Am exhibits outstanding photocatalytic performance, with a CO generation rate of 1380 µmol g−1 h−1 and 94% CO selectivity under visible light, significantly surpassing the majority of MOF‐based photocatalysts reported to date. Furthermore, experimental characterizations reveal that Ni‐74‐Am has significantly higher efficiency of photogenerated electron–hole separation and faster carrier migration rate for photocatalytic CO2 reduction. This work enriches the design and application of defective MOFs and provides new insights into the design of MOF‐based photocatalysts for renewable energy and environmental sustainability. The findings of this study hold significant promise for developing efficient photocatalysts for CO2 reduction under visible‐light conditions.
Unlocking High Porosity: Post‐Synthetic Solvothermal Treatment of Cu‐Paddlewheel Based Metal–Organic Cages
Authors: Lee Byeongchan , Go Bogyeong , Jung Byunghyuck , Park Jinhee 
Published: December 2023

AbstractMetal–organic cages (MOCs) have garnered significant attention due to their unique discrete structures, intrinsic porosity, designability, and tailorability. However, weak inter‐cage interactions, such as van der Waals forces and hydrogen bonding can cause solid‐state MOCs to lose structural integrity during desolvation, leading to the loss of porosity. In this work, a novel strategy to retain the permanent porosity of Cu‐paddlewheel‐based MOCs, enabling their use as heterogeneous catalysts is presented. Post‐synthetic solvothermal treatments in non‐coordinating solvents, mesitylene, and p‐xylene, effectively preserve the packing structures of solvent‐evacuated MOCs while preventing cage agglomeration. The resulting MOCs exhibit an exceptional N2 sorption capacity, with a high surface area (SBET = 1934 m2 g−1 for MOP‐23), which is among the highest reported for porous MOCs. Intriguingly, while the solvothermal treatment reduced Cu(II) to Cu(I) in the Cu‐paddlewheel clusters, the MOCs with mixed‐valenced Cu(I)/Cu(II) maintained their crystallinity and permanent porosity. The catalytic activities of these MOCs are successfully examined in copper(I)‐catalyzed hydrative amide synthesis, highlighting the prospect of MOCs as versatile reaction platforms.
Phase‐Change Based Oxygen Carriers Improve Acute Cerebral Hypoxia
Authors: Ye Qingsong , Zheng Deyuan , Chen Kaiyuan , Xu Haiheng , Yang Zefeng , Wen Jiqiu , Hu Yiqiao , Wu Jinhui 
Published: December 2023

AbstractStroke is the second leading cause of death worldwide, and hypoxia is a major crisis of the brain after stroke. Therefore, providing oxygen to the brain microenvironment can effectively protect neurons from damage caused by cerebral hypoxia. However, there is a lack of timely and effective means of oxygen delivery clinically to the brain for acute cerebral hypoxia. Here, a phase‐change based nano oxygen carrier is reported, which can undergo a phase change in response to increasing temperature in the brain, leading to oxygen release. The nano oxygen carrier demonstrate intracerebral oxygen delivery capacity and is able to release oxygen in the hypoxic and inflammatory region of the brain. In the acute ischemic stroke mouse model, the nano oxygen carrier can effectively reduce the area of cerebral infarction and decrease the level of inflammation triggered by cerebral hypoxia. By taking advantage of the increase in temperature during cerebral hypoxia, phase‐change oxygen carrier proposes a new intracerebral oxygen delivery strategy for reducing acute cerebral hypoxia.
Optimization Strategy in Hydrogen Storage Performance of Ti─V─Cr─Mn Alloys via LiAlH4
Authors: Ding Nan , Liu Wanqiang , Yin Dongming , Zhao Shaolei , Qiao Wenfeng , Xiu Haixiang , Liu Cong , Shi Qingyun , Wang Limin , Cheng Yong 
Published: December 2023

AbstractV‐based solid solution materials hold a significant position in the realm of hydrogen storage materials because of its high hydrogen storage capacity. However, the current dehydrogenation temperature of V‐based solid solution exceeds 350 °C, making it challenging to fulfill the appliance under moderate conditions. Here advancements in the hydrogen storage properties and related mechanisms of TiV1.1Cr0.3Mn0.6 + x LiAlH4 (x = 0, 5, 8, 10 wt.%) composites is presented. According to the first principle calculation analysis, the inclusion of Al and Li atoms will lower the binding energy of hydride, thus enhancing the hydrogen absorption reaction and significantly decreasing the activation difficulty. Furthermore, based on crystal orbital Hamilton population (COHP) analysis, the strength of the V─H and Ti─H bonds after doping LiAlH4 are reduced, leading to a decrease of the hydrogen release activation energy (Ea) for the V‐based solid solution material, thus the hydrogen release process is easier to carry out. Additionally, the structure of doped LiAlH4 exhibits an outstanding hydrogen release rate of 2.001 wt.% at 323 K and remarkable cycling stability.
Multifunctional Biodegradable Conductive Hydrogel Regulating Microenvironment for Stem Cell Therapy Enhances the Nerve Tissue Repair
Authors: Xu Chao , Wu Ping , Yang Kun , Mu Congpu , Li Binbin , Li Xiaokun , Wang Zhouguang , Liu Zhongyuan , Wang Xinyu , Luo Zhiqiang 
Published: December 2023

AbstractThe nerve guidance conduits incorporated with stem cells, which can differentiate into the Schwann cells (SCs) to facilitate myelination, shows great promise for repairing the severe peripheral nerve injury. The innovation of advanced hydrogel materials encapsulating stem cells, is highly demanded for generating supportive scaffolds and adaptive microenvironment for nerve regeneration. Herein, this work demonstrates a novel strategy in regulating regenerative microenvironment for peripheral nerve repair with a biodegradable conductive hydrogel scaffold, which can offer multifunctional capabilities in immune regulation, enhancing angiogenesis, driving SCs differentiation, and promoting axon regrowth. The biodegradable conductive hydrogel is constructed by incorporation of polydopamine‐modified silicon phosphorus (SiP@PDA) nanosheets into a mixture of methacryloyl gelatin and decellularized extracellular matrix (GelMA/ECM). The biomimetic electrical microenvironment performs an efficacious strategy to facilitate macrophage polarization toward a pro‐healing phenotype (M2), meanwhile the conductive hydrogel supports vascularization in regenerated tissue through sustained Si element release. Furthermore, the MSCs 3D‐cultured in GelMA/ECM‐SiP@PDA conductive hydrogel exhibits significantly increased expression of genes associated with SC‐like cell differentiation, thus facilitating the myelination and axonal regeneration. Collectively, both the in vitro and in vivo studies demonstrates that the rationally designed biodegradable multifunctional hydrogel significantly enhances nerve tissues repair.
Sulfurized NiFe2O4 Electrocatalyst with In Situ Formed Fe‐NiOOH Nanoparticles to Realize Industrial‐Level Oxygen Evolution
Authors: Li Xiang , Wang Mengna , Fu Jie , Lu Fang , Li Zhenyu , Wang Guoxiong 
Published: December 2023

AbstractConstructing composite catalysts with refined geometric control and optimal electronic structure provides a promising route to enhance electrocatalytic performance toward the oxygen evolution reaction (OER). Herein, a composite catalyst is prepared with multiple components using chemical vapour deposition method to transform crystalline NiFe2O4 into crystalline NiFe2O4@amorphous S‐NiFe2O4 with core‐shell structure (C‐NiFe2O4@A‐S‐NiFe2O4), and Fe‐NiOOH nanoparticles are subsequently in situ generated on its surface during the process of electrocatalytic OER. The C‐NiFe2O4@A‐S‐NiFe2O4 catalyst exhibits a low overpotential of 275 mV while possessing an excellent stability for 500 h at 10 mA cm−2. The anion exchange membrane water electrolyzer with C‐NiFe2O4@A‐S‐NiFe2O4 anode catalyst obtains a current density of 4270 mA cm−2 at 2.0 V. Further, in situ Raman spectroscopy result demonstrates that in situ generated Fe‐NiOOH nanoparticles are revealed to act as the catalytic active phase for catalyzing the OER. Besides, introducing A‐S‐NiFe2O4 in C‐NiFe2O4@A‐S‐NiFe2O4 facilitates the formation of Fe‐NiOOH nanoparticles with high‐valency Ni, thus increasing the proportion of lattice oxygen‐participated OER. This work not only provides an alternative strategy for the design of high‐performance catalysts, but also lays a foundation for the exploration of catalytic mechanisms.
Macroflora from Lower Jurassic (Pliensbachian) of Hicks Creek, southern Talkeetna Mountains, south‐central Alaska
Authors: Barbacka Maria , Górecki Artur , Pott Christian , Ziaja Jadwiga , Blodgett Robert B. , Metzler Curvin , Caruthers Andrew H. , Edirisooriya Geethanalje , Pacyna Grzegorz 
Published: December 2023

AbstractA recently discovered Early Jurassic locality at Hicks Creek, Talkeetna Mountains, Alaska, yielded a macrofossil plant assemblage comprising predominantly bennettitaleans and ferns, accompanied by horsetails, seed ferns, cycads and conifers. Single species from different plant groups dominate the assemblage (e.g. Cladophlebis alata, Otozamites pterophylloides; less frequent Rhaphidopteris sp. and Pagiophyllum falcatum; sporadic Thallites sp., Klukia sp., Todites williamsonii, Coniopteris bella, Sagenopteris sp., Zamites sp., Nilssoniopteris pristis, Pseudoctenis sp., Eretmophyllum sp. and Elatides sp.). We also encountered a new foliage of cycadophyte type, Hanophyllum varioserratum gen. et sp. nov. Hicks Creek is one of four Alaskan areas with fossil Mesozoic plants that have been investigated. Along with rocks of Puale Bay and the East Fork of Boulder Creek exposures, this locality is of Early Jurassic age, while Cape Lisburne is Early Cretaceous (Albian). Based on a comparison of the floral composition of Hicks Creek with some other localities (Alaska and beyond), environmental conditions for the Peninsular terrane are inferred. Floristic differences between localities are explained by the varied topography, interpreted as disturbed coastal–lagoonal or as undisturbed, moist and warm inland. Some taxa (Todites williamsonii, Coniopteris bella, Nilssoniopteris pristis, Otozamites tenuatus, O. mimetes, Brachyphyllum crucis) common to the Alaska Peninsula and Middle Jurassic of Yorkshire may suggest a possible pathway of plant migration during the movement of the Peninsular terrane. The occurrence of Cladophlebis alata in the Lower Jurassic of south‐central Alaska and the Lower Cretaceous of northwestern Alaska may also shed light on the posited spread of this species.
Pathways to well‐being in Tarumajaya, West Java: Post‐COVID 19 supporting better access to the commons through engagement and a critical systemic reflection on stories
Authors: Wirawan Rudolf , McIntyre‐Mills Jane Judy , Riswanda R. , Widianingsih Ida , Gunawan Indra 
Published: December 2023

AbstractThis paper explores the concept of community engagement, aligned with President Jokowi's mission to promote social enterprises, as a means to support the development of a re‐generative circular green economy in Tarumajaya, West Java. The primary focus is on enhancing farming, fishing, and forestry activities with villagers. The Covid‐19 pandemic presented significant challenges for the villagers, particularly in marketing their goods, resulting in financial hardships and an increased vulnerability to debt traps, particularly affecting women. Additionally, a major obstacle to achieving regenerative living is the limited access to land, with approximately 80% of the villagers either landless or owning small plots. Moreover, fishing restrictions imposed by the military to protect the Citarum River have further curtailed access to common grazing land for cattle. Preliminary analysis indicates that adopting intensive farming methods, such as rabbit breeding, mushroom cultivation, and fertiliser production, holds promise for reducing the community's carbon footprint. Overcoming these challenges and mapping pathways towards regenerative living are central objectives of this case study, providing insights and practical strategies to foster sustainable economic and environmental progress in Tarumajaya. Key components of the approach include finding markets for village products, extending access to common resources such as rivers, forests, and hillside terraces to villagers, and providing mentorship to women for supporting their small enterprises. The ongoing partnership with the village involves a community of practice consisting of universities and nongovernmental organisations, while private sector entities, including a gas company and tea and coffee plantations, are engaged in negotiations with the village head to secure additional land access. This study highlights the combination of challenges arising from the lack of access to common resources, limited market opportunities, and the influence of predatory financial institutions during the pandemic. By working closely with the villagers, the case study aims to identify opportunities and support the transition towards a green circular economy that moves away from business as usual and promotes regenerative living.