bluuebunny/crossref_metadata_2025_split huggingface dataset:
Identification of AP002498.1 and LINC01871 as prognostic biomarkers and therapeutic targets for distant metastasis of colorectal adenocarcinoma
Authors: Wu Na , Chen Jingyi , Lin Tingru , Zhong Zhaohui , Li Mei , Yu Yimeng , Guo Jingzhu , Yu Weidong 
Published: December 2023

AbstractBackgroundIncreasing evidence suggests that lncRNA (Long non‐coding RNA, lncRNA)‐mediated ceRNA (competing endogenous RNA, ceRNA) networks are involved in the occurrence and progression of colorectal cancer (CRC). However, the roles of the lncRNA–miRNA–mRNA ceRNA network in distant metastasis of CRC are still unclear.MethodsIn this study, we constructed a specific ceRNA network to identify potential biomarkers and therapeutic targets for distant metastasis of CRC. Specifically, RNA‐Seq data from The Cancer Genome Atlas (TCGA) were used to screen for differentially expressed lncRNAs (DElncRNAs) and mRNAs (DEmRNAs) related to metastasis. After validation and selection by qRT–PCR and univariate and multivariate analysis of the metastasis‐ and prognosis‐related lncRNAs, the regulated microRNAs (miRNAs) and coexpressed mRNAs were used to construct a ceRNA network for distant metastasis of CRC.ResultsTwo key distant metastasis‐related DElncRNAs, AP002498.1 and LINC01871, were identified by univariate and multivariate analysis in combination with analyses of clinical data and expression levels. Furthermore, lncRNA‐associated ceRNA subnetworks were constructed from the predicted miRNAs and 13 coexpressed DEmRNAs (SERPINA1, ITLN1, REG4, L1TD1, IGFALS, MUC5B, CIITA, CXCL9, CXCL10, GBP4, GNLY, IDO1, and NOS2). The AP002498.1‐ and LINC01871‐associated ceRNA subnetworks regulated the expression of the target genes SERPINA1 and MUC5B and GNLY, respectively, through the associated miRNAs.ConclusionThe DElncRNA AP002498.1 and the LINC01871/miR‐4644 and miR‐185‐5p/GNLY axes were identified as being closely associated with distant metastasis and could represent independent prognostic biomarkers or therapeutic targets in colorectal adenocarcinoma.
Transcatheter mitral valve replacement with Mi‐thos system: First‐in‐human experience
Authors: Yang Ye , Chen Jinmiao , Dong Lili , Lu Yuntao , Lv Minzhi , Guo Kefang , Bagaber Ghufran , Yang Jian , Wang Chunsheng , Wei Lai 
Published: December 2023

AbstractBackgroundTranscatheter mitral valve replacement (TMVR) has become an alternative for high‐risk patients with severe mitral regurgitation (MR). The aim of this study was to evaluate the safety and feasibility of the Mi‐thos TMVR system (NewMed Medical) for high‐risk patients with severe MR.MethodsThis was a prospective, two‐center, single‐arm early feasibility study. Baseline characteristics, procedural data and 30‐day follow‐up outcomes were collected and analyzed. The primary endpoint was intraoperative success rate of device implantation. The second endpoints were all‐cause mortality and major post‐procedural complications. Echocardiographic data were evaluated by an independent core laboratory. Clinical events were adjudicated by a clinical events committee.ResultsTen high‐risk patients with severe MR were enrolled at two sites from August 2021 to November 2022. The median age was 70.5 years, and 60% of patients were female. The median Society of Thoracic Surgeons Predicted Risk of Mortality was 9.5%. The Mi‐thos TMVR system was successfully implanted via transapical access in all patients. There was no pericedural mortality or major postpericedural complications during the 30‐day follow‐up. All implanted prosthetic valves had no or trace valvular or paravalvular MR, and the median mitral valve gradient at 30 days was 2.0 mmHg (IQR: 2.0–3.0 mmHg). There was one mild left ventricular outflow tract obstruction.ConclusionsThe favorable short‐term outcomes of the Mi‐thos TMVR system demonstrated that it might be a feasible and safe therapeutic alternative for high‐risk patients with severe MR. Nevertheless, further evaluation of the Mi‐thos TMVR system is warranted.
A rare case of dual coronary cameral fistulae
Authors: Ozgur Sacide S. , Shamoon Yezin , Abboud Rachel , Shaqra Hussein , Shamoon Fayez 
Published: December 2023

Key Clinical MessageDual coronary cameral fistulae (CCFs) are rare abnormal connections between coronary arteries and heart chambers. Management of CCFs remains a topic of debate, emphasizing the need for individualized approach based on presentation.AbstractWe present a rare case of dual coronary cameral fistulae originating from the mid‐left anterior descending (LAD) and the mid‐right coronary artery (RCA) with drainage into the left ventricle, diagnosed incidentally during coronary angiography.
Spontaneous hemothorax caused by rivaroxaban treatment for pulmonary embolism: A case report
Authors: Al Hariri Bassem , Alharafsheh Ahmad Taher , Hassan Muad Abdi , Nashwan Abdulqadir J. , Mohamedali Mohamed Gaafar , Abusriwil Hatem Mabrouk 
Published: December 2023

Key Clinical MessageHemothorax is a rare and potentially fatal condition characterized by pleural effusion containing over 50% of the patient's hematocrit. A massive hemothorax involves blood loss exceeding 1.5 L. Common causes include chest trauma, invasive thoracic procedures, anticoagulant medications, vascular anomalies, malignancies, and hematologic abnormalities. Spontaneous hemothorax may be seen in conjunction with pulmonary infarction and spontaneous pneumothorax. Anticoagulation is a key therapeutic strategy for certain thromboembolic events, such as pulmonary embolism. Historically, these events were treated with vitamin K antagonists (VKAs), which have demonstrated variable plasma concentrations and an increased risk of hemorrhage. With the advent of direct oral anticoagulants (DOACs), treatment has become as effective as VKAs while significantly reducing the risk of hemorrhage. However, some researchers have speculated that hemorrhagic complications in certain cases could be worse with DOACs than with VKAs. In the case presented here, we identified a genuine association between the use of rivaroxaban and spontaneous hemothorax following the initiation of treatment for pulmonary embolism.
Enhanced catalytic oxidation via nano Cu0.5Mg0.5Fe2O4 embedded in CNTs for adsorption–reduction of hexavalent chromium
Authors: Zhang Pan , Wu Qiuying , Wang Wei , Yang Xiushan 
Published: December 2023

AbstractA catalyst consisting of Cu0.5Mg0.5Fe2O4 (CMF) supported on carbon nanotubes (CNTs) which exhibits great potential as an adsorbent for treating Cr(VI)‐contaminated wastewater has been successfully prepared. The ferrite possesses excellent magnetic properties, while CNTs have the advantage of a large surface area. This composite material not only prevents the aggregation of magnetic materials and enhances the exposure of active sites but also effectively solves the recycling problem of CNTs. Our results show that the adsorption capacity of Cu0.5Mg0.5Fe2O4–carbon nanotubes (CMF‐CNTs) for Cr(VI) wastewater (45.60 mg/g) is 1.49 times higher than that of Cu0.5Mg0.5Fe2O4 (30.48 mg/g). Compared to a single catalyst, CMF‐CNTs not only improve the dispersibility of magnetic materials but also exhibit synergistic effects between the composite materials, enhancing the chemical adsorption capacity. After five consecutive adsorption and desorption experiments, the adsorption capacity of CMF‐CNTs remains at 88% of its initial value. Furthermore, the study of the catalyst before and after adsorption by XPS reveals that the valence state transition of Fe3+/Fe2+ and Cu2+/Cu+ plays a crucial role in the adsorption process. The results of this study demonstrate the potential of using waste materials for effective wastewater treatment and provide insights into the development of new adsorbents for pollutant removal.
PROTOCOL: The effectiveness of skills training to increase employment among those experiencing and at risk of homelessness: A systematic review
Authors: Li Zijun , Ma Mina , Yang Yongqi , Li Yanfei , Guo Ke , Yang Minyan , Liu Guanghua , Yang Kehu 
Published: December 2023

AbstractThis is the protocol for a Campbell systematic review. The objectives are as follows. We will solve the following questions: (1) What are the characteristics of skills training services for individuals experiencing or at risk of homelessness? (2) How effectively do the different skills training programs improve employment status, work and life skills, or housing stability? (3) What factors are associated with the variation in the effectiveness of skills training services?
Adaptation and plasticity of yield in hybrid and inbred sorghum
Authors: Otwani Daniel , Hunt Colleen , Cruickshank Alan , Powell Owen , Koltunow Anna , Mace Emma , Jordan David 
Published: December 2023

AbstractLocal adaptation and genotype by environment (G×E) interactions affect the expression of phenotypes in crop species. An investigation on the interplay between adaptation and G×E on sorghum heterosis phenotypes is lacking. To address this question, a set of 112 diverse grain sorghum hybrids and their 22 inbred parents of local and exotic origins, representing the primary female and male heterotic groups, were tested in five contrasting sorghum‐growing environments across 2 years in Queensland, Australia. Plant height, days to flowering, seed yield, grain weight, and grain number were measured and used in the estimation of heterosis. Midparent heterosis for yield ranged from –25% to 217% and was highly influenced by grain number. In contrast to observations in maize, the magnitude of heterosis for yield was not associated with site mean. Striking differences were observed in heterosis in hybrids from locally developed inbred parents compared with hybrids that were developed from exotic inbred parents developed in other countries. Heterosis in the latter combination was higher on average across all the test environments for the majority of traits. We hypothesize maladaptive phenotypic plasticity in the exotic parents contributed to the observed differences in heterosis estimates. These data confirm that heterosis estimates in sorghum must be obtained and interpreted in relevant genetic and environmental contexts. Breeders in developing countries with low sorghum hybrid seed uptake will find these insights useful when selecting hybrids for broader adaptation, improving efficiency of their breeding programs.
Natural habitat connectivity and organic management modulate pest dispersal, gene flow, and natural enemy communities
Authors: Novaes Danyelle R. , Sujii Patricia S. , Rodrigues Camila A. , Silva Karen M. N. B. , Machado Amanda F. P. , Inoue‐Nagata Alice K. , Nakasu Erich Y. T. , Togni Pedro H. B. 
Published: December 2023

AbstractThe simplification and fragmentation of agricultural landscapes generate effects on insects at multiple spatial scales. As each functional group perceives and uses the habitat differently, the response of pest insects and their associated natural enemies to environmental changes varies. Therefore, landscape structure may have consequences on gene flow among pest populations in space. This study aimed to evaluate the effects of local and landscape factors, at multiple scales, on the local infestation, gene flow and broad dispersion dynamics of the pest insect Bemisia tabaci (Genn.) Middle East‐Asia Minor 1 (MEAM‐1, former biotype B) (Hemiptera: Aleyrodidae) and its associated natural enemies in a tropical agroecosystem. We evaluated the abundance of B. tabaci populations and their natural enemy community in 20 tomato farms in Brazil and the gene flow between farms from 2019 to 2021. Landscapes dominated by agriculture resulted in larger B. tabaci populations and higher gene flow, especially in conventional farms. A higher density of native vegetation patches disfavored pest populations, regardless of the management system. The results revealed that whitefly responds to intermediate spatial scales and that landscape factors interact with management systems to modulate whitefly populations on focal farms. Conversely, whitefly natural enemies benefited from higher amounts of natural vegetation at small spatial scales, while the connectivity between natural habitat patches was beneficial for natural enemies regardless of the distance from the focal farm. The resulting dispersion model predicts that the movement of whiteflies between farms increases as the amount of natural vegetation decreases. Our findings demonstrate that landscape features, notably landscape configuration, can mediate infestation episodes, as they affect pest insects and natural enemies in opposite ways. We also showed that landscape features interact with farm traits, which highlights the need for management strategies at multiple spatial scales. In conclusion, we demonstrated the importance of the conservation of natural areas as a key strategy for area‐wide ecological pest management and the relevance of organic farming to benefit natural enemy communities in tropical agroecosystems.
Facilitating the recovery of insect communities in restored streams by increasing oviposition habitat
Authors: Dilworth Samantha , Taylor Brad W. 
Published: December 2023

AbstractRecruitment limitation is known to influence species abundances and distributions. Recognition of how and why it occurs both in natural and in designed environments could improve restoration. Aquatic insects, for instance, rarely reestablish in restored streams to levels comparable to reference streams even years after restoration. We experimentally increased oviposition habitat in five out of 10 restored streams in western North Carolina to test whether insect egg‐laying habitat was limiting insect populations in restored streams. A main goal was to test whether adding oviposition habitat in the form of rocks that partially protrude above the water surface could be used to increase the abundance and richness of stream insect eggs and larval insects in restored streams. Adding egg‐laying habitat enhanced several response variables (e.g., protruding rocks, number of eggs, egg masses, egg morphotype richness, and oviposition habitat stability) to levels similar to those found in reference streams. Following the addition of protruding rocks, egg mass abundance increased by 186% and richness by 77% in restored‐treated streams. Densities of larval insects that attached their eggs to protruding rocks showed an overall pattern consistent with treatment effects due to the combination of nonsignificant and significant increases of several taxa and not just one taxon. Our results indicate that these stream insect populations are limited by oviposition habitat and that adding egg‐laying habitat alleviated this component of recruitment limitation. However, the weaker larval response indicates that additional post‐recruitment factors, such as egg or larval mortality, may still be limiting a full recovery of larval insect abundances in these restored streams. This study shows the importance of integrating information from animal life histories, ecology, and geomorphology into restoration practices to improve the recovery of aquatic insects, which are commonly used to assess water quality and the biological efficacy of stream restoration.
Proximity‐sensors on GPS collars reveal fine‐scale predator–prey behavior during a predation event: A case study from Scandinavia
Authors: Tallian Aimee , Mattisson Jenny , Stenbacka Fredrik , Neumann Wiebke , Johansson Anders , Støen Ole Gunnar , Kindberg Jonas 
Published: December 2023

AbstractAlthough the advent of high‐resolution GPS tracking technology has helped increase our understanding of individual and multispecies behavior in wildlife systems, detecting and recording direct interactions between free‐ranging animals remains difficult. In 2023, we deployed GPS collars equipped with proximity sensors (GPS proximity collars) on brown bears (Ursus arctos) and moose (Alces alces) as part of a multispecies interaction study in central Sweden. On 6 June, 2023, a collar on an adult female moose and a collar on an adult male bear triggered each other's UHF signal and started collecting fine‐scale GPS positioning data. The moose collar collected positions every 2 min for 89 min, and the bear collar collected positions every 1 min for 41 min. On 8 June, field personnel visited the site and found a female neonate moose carcass with clear indications of bear bite marks on the head and neck. During the predation event, the bear remained at the carcass while the moose moved back and forth, moving toward the carcass site about five times. The moose was observed via drone with two calves on 24 May and with only one remaining calf on 9 June. This case study describes, to the best of our knowledge, the first instance of a predation event between two free ranging, wild species recorded by GPS proximity collars. Both collars successfully triggered and switched to finer‐scaled GPS fix rates when the individuals were in close proximity, producing detailed movement data for both predator and prey during and after a predation event. We suggest that, combined with standard field methodology, GPS proximity collars placed on free‐ranging animals offer the ability for researchers to observe direct interactions between multiple individuals and species in the wild without the need for direct visual observation.
The effect of self‐management techniques on relevant outcomes in chronic low back pain: A systematic review and meta‐analysis
Authors: Scholz C. , Schmigalle P. , Plessen C. Y. , Liegl G. , Vajkoczy P. , Prasser F. , Rose M. , Obbarius A. 
Published: December 2023

AbstractBackground and ObjectiveAmong many treatment approaches for chronic low back pain (CLBP), self‐management techniques are becoming increasingly important. The aim of this paper was to (a) provide an overview of existing digital self‐help interventions for CLBP and (b) examine the effect of these interventions in reducing pain intensity, pain catastrophizing and pain disability.Databases and Data TreatmentFollowing the PRISMA guideline, a systematic literature search was conducted in the MEDLINE, EMBASE, PsychInfo, CINAHL and Cochrane databases. We included randomized controlled trials from the last 10 years that examined the impact of digital self‐management interventions on at least one of the three outcomes in adult patients with CLBP (duration ≥3 months). The meta‐analysis was based on random‐effects models. Standardized tools were used to assess the risk of bias (RoB) for each study and the quality of evidence for each outcome.ResultsWe included 12 studies (n = 1545). A small but robust and statistically significant pooled effect was found on pain intensity (g = 0.24; 95% CI [0.09, 0.40], k = 12) and pain disability (g = 0.43; 95% CI [0.27, 0.59], k = 11). The effect on pain catastrophizing was not significant (g = 0.38; 95% CI [−0.31, 1.06], k = 4). The overall effect size including all three outcomes was g = 0.33 (95% CI [0.21, 0.44], k = 27). The RoB of the included studies was mixed. The quality of evidence was moderate or high.ConclusionIn summary, we were able to substantiate recent evidence that digital self‐management interventions are effective in the treatment of CLBP. Given the heterogeneity of interventions, further research should aim to investigate which patients benefit most from which approach.SignificanceThis meta‐analysis examines the effect of digital self‐management techniques in patients with CLBP. The results add to the evidence that digital interventions can help patients reduce their pain intensity and disability. A minority of studies point towards the possibility that digital interventions can reduce pain catastrophizing. Future research should further explore which patients benefit most from these kinds of interventions.
Earthworm‐Inspired Triboelectric Nanogenerator with O‐Shaped Multilayer Structure for Marine Ranching
Authors: Yang Hanxiao , Miao Xue , Li Zekun , Cui Weiqi , Zhao Yilin , Cheng Meifei , Yu Aifang , Zhai Junyi 
Published: December 2023

In view of the characteristics of small wave amplitude, stable direction, and low frequency near marine ranching, an energy‐harvesting device is designed and produced through an O‐shaped multilayer earthworm‐like triboelectric nanogenerator (OME–TENG) to provide a self‐sufficient energy supply for sensors without relying on batteries. Under the same conditions, O‐shaped multilayer TENG structure can carry out a fuller contact‐separation movement due to its unique O‐shaped structure, thus the peak power of the O‐shaped multilayer TENG structure can reach 10.4 mW, which is more than twice that of the Z‐shaped multilayer TENG structure. When the water wave frequency is 0.5 Hz and the wave amplitude is about 7.5 cm, the open‐circuit voltage, short‐circuit current, and transferred charge of the left units of the OME–TENG device can reach 300 V, 25 μA, and 900 nC, respectively, and can directly light up 107 light emitting diode. After rectification and parallel connection, the energy collected by the OME–TENG can easily power a digital hygrograph to monitor marine temperature and humidity. Therefore, the OME–TENG shows great application prospects in the energy supply of marine ranching.
Research progress on the influencing factors and enhancement mechanism of CH4/CO2 mixture separation process by hydrate‐based technology: A review
Authors: Zhang Xuemin , Yin Shaoqi , He Jiajing , Liu Qingqing , Li Jinping , Wang Yingmei 
Published: December 2023

AbstractThe separation of mixed gas by hydrate method can realize the efficient separation of CO2 gas from biological gas. However, the long period, slow rate, and low selectivity of hydration reaction have become the critical problems restricting the efficient separation of the gas mixture by hydrate method. In this review, the formation characteristics of CH4/CO2 mixed gas hydrate are systematically summarized, and the kinetic process and influencing factors of CH4/CO2 mixed gas hydrate formation are comprehensively analyzed. On this basis, the influence mechanism and law of temperature, pressure, gas–liquid ratio, gas component ratio, additives, and other factors on the CH4/CO2 mixed gas hydrate formation progress were described in detail, and the enhancement mechanism of CH4/CO2 mixed gas hydrate formation under the influence of different factors was analyzed. Finally, the shortcomings and future development directions of the purification and separation technology of CH4/CO2 mixed gas by hydrate method are pointed out. Further research is needed to understand the kinetic mechanism and enhancement mechanism of the CH4/CO2 mixture separation process by hydrate method. The relative results will provide valuable guidance for the separation of mixture gas by a hydrate‐based method.