bluuebunny/crossref_metadata_2025_split huggingface dataset:
Pengaruh Retribusi Izin Mendirikan Bangunan dan Retribusi Parkir Terhadap Penerimaan Retribusi Daerah Kota Jambi
Authors: Soleh Ahmad , Daniel Prima Audia , Rahayu Yunie , Ramadani Nurul Sakinah 
Published: December 2023

Penelitian ini bertujuan untuk menganalisis pengaruh retribusi izin mendirikan bangunan dan retribusi parkir terhadap penerimaan retribusi daerah Kota Jambi. Metode analisis yang digunakan yaitu analisis deskriptif dan kuantitatif. Alat analisis yang digunakan adalah regresi sederhana. Hasil penelitian ini menunjukkan bahwa data pendapatan retribusi izin mendirikan bangunan dan retribusi parkir di Kota Jambi selama periode 2012 hingga 2022, dapat disimpulkan bahwa data retribusi parkir berpengaruh positif tetapi tidak signifikan. Berdasarkan data kontribusi retribusi izin mendirikan bangunan dan retribusi parkir terhadap pendapatan retribusi daerah Kota Jambi selama periode 2012 hingga 2022, dapat disimpulkan bahwa terdapat fluktuasi yang signifikan dalam kontribusi keduanya. Dari hasil analisis regresi data pendapatan retribusi daerah Kota Jambi, ditemukan bahwa nilai koefisien Retribusi Daerah, retribusi IMB, dan retribusi parkir semuanya memiliki arah positif.
Ameliyathanede Çalışan Hemşirelerin Çalışma Ortamı ile Hasta Güvenliği Tutumları Arasındaki İlişki: Kesitsel Çalışma
Authors: ÖZKAN Sultan , ARSLAN Ezgi , ÇİNAR Halise 
Published: December 2023

Amaç: Bu çalışmada ameliyathanede çalışan hemşirelerin çalışma ortamına yönelik tutumlarının hasta güvenliği tutumlarına etkisinin belirlenmesi amaçlanmıştır.
Yöntem: Çalışma, Mayıs-Kasım 2021 tarihleri arasında, Türkiye’nin batısında bulunan bir ilde ve analitik-kesitsel tipte gerçekleştirildi.
Bulgular: Bu çalışmaya katılan ameliyathane hemşirelerinin %80’inin altı yıl ve üzerinde kurumda çalıştığı, %72,9’unun hasta güvenliğin konusunda eğitim aldığı ve eğitim alanların da yarısından fazlasının hizmet içi eğitimle bilgilendiği belirlendi. Ameliyathane hemşirelerinin Hemşirelik İş İndeksi-Hemşirelik Çalışma Ortamı Ölçeği puan ortalaması 2,24±0,43’tür. Güvenlik Tutumları Ölçeği puan ortalaması 50,86±6,71’dir. Çalışmaya katılanların iş ortamına yönelik tutumları “orta seviyenin biraz üzerinde” ve güvenlik tutumları ise “orta seviye” olarak belirlendi.
Sonuç: Ameliyathanede çalışan hemşirelerin verimli olmaları, mesleki doyum sağlamalarına ve kurumlarda verilen hemşirelik bakımının kalitesinin arttırılması adına ameliyathane ortamı ve hasta güvenliği tutumlarının belirlenerek iyileştirilmesi yönünde planlamalar yapılabilir.
Nghiên cứu chế tạo và đánh giá một số tính chất của vật liệu nano lưỡng kim Fe/Cu hóa trị 0 bằng phương pháp hóa học xanh
Authors: Nguyen Son , Vũ Ngọc Toán  , Nguyễn Văn Hoàng  , Nguyễn Thị Thu Hương  
Published: December 2023

Bài báo giới thiệu kết quả nghiên cứu chế tạo vật liệu nano lưỡng kim Fe/Cu hóa trị 0 bằng tác nhân polyphenol được chiết xuất từ lá trà xanh Việt Nam. Ảnh hưởng của một số yếu tố đến quy trình chế tạo đã được nghiên cứu, cho thấy, nano lưỡng kim Fe/Cu hóa trị 0 có chất lượng tốt nhất khi phân tán trong hỗn hợp dung môi ethanol/H2O 4/1(v/v); nồng độ polyphenol trong dịch chiết trà xanh 12,5 g/L; tỷ lệ Fe/Cu là 5/1, pH = 3 - 4, nhiệt độ 25 - 28 oC. Vật liệu nano lưỡng kim Fe/Cu có hoạt tính duy trì ổn định trong 35 ngày, d = 0,921 g/cm3, kích thước hạt 37 - 45 nm và chứa các nhóm hydroxyl trên bề mặt.
Entrenamiento y evaluación de la capacidad física militar. Revisión de la literatura
Authors: NIETO Claudio , CÁRCAMO Marcela 
Published: December 2023

Introducción: La capacidad física militar es una entidad, interviniendo tres
componentes principales: producción de energía, función neuromuscular y factores
psicológicos. Objetivos: revisar en la literatura los aspectos comunes con
Ejércitos, para medir capacidad física militar de acuerdo a los tipos de misión que
poseen, analizar contenido de programas entrenamiento físico y valorar evidencias
de estos. Método: Revisión narrativa. Se utilizaron como bases de datos Pubmed,
TripData Base, Epistemonikos y Lilacs. Se utilizaron palabras claves: “condición
física militar”, “aptitudes de combate”, “condición aeróbica” y “valoración funcional”,
todos términos libres. Resultados: Se observa una tendencia a abordar capacidad
física militar en contextos militares desde prácticas basadas en evidencia;
los contenidos en programas de entrenamiento físico y su certificación, se basan en
asociación con tareas militares habituales. Conclusión: se sugiere que la medición
de los programas de entrenamiento debe ser en función de tareas militares con distintas
misiones y escenarios geográficos.
Implementación del puzle de Aronson apoyado en el Flipped Classroom para la medición de la condición física en los alumnos de 2º de ESO
Authors: Martínez Campillo Raul L. 
Published: December 2023

La presente investigación tiene como principal objetivo desarrollar la autonomía
del alumnado en un marco tan importante para el docente de Educación Física
como es la evaluación de la Condición Física.
Para este propósito, se ha utilizado una conjunción de metodologías que ha
permitido aunar la técnica de Puzle de Aronson, estrategia propia del aprendizaje
cooperativo, con el Flipped Classroom, metodología activa que está cobrando importancia
en la actualidad.
Se ha optado por un diseño de investigación basado en la investigación evaluativa
(modelo CIPP de Stufflebeam), para ello se han determinado dos momento
para la obtención de información por medio de un pre-test y post-test. Los resultados
obtenidos muestran mejoras significativas en la motivación y satisfacción, así
como en la valoración positiva de la metodología empleada en el estudio.
15-18 Yaş Aralığındaki Sporcuların Karakter Düzeylerinin İncelenmesi
Authors: ÖZLÜ Canberk , YALIZ SOLMAZ Dilek , GÜVEN Gülsün 
Published: December 2023

Amaç: Bu çalışmanın amacı 15-18 yaş arası sporcuların karakter düzeylerinin farklı değişkenlere göre belirlenmesidir.
Gereç ve Yöntem: Bu çalışmada tarama modeli kullanılmıştır. Araştırmanın evrenini 15-18 yaş aralığındaki lisanslı sporcular oluşturmaktadır. Araştırmanın örneklemini ise amaçlı örnekleme yöntemi kullanılarak seçilen toplamda 405 (127 kız, 278 erkek) sporcu oluşturmaktadır. Verilerin toplamasında “Spor Karakter Ölçeği” kullanılmıştır. Verilerin analizinde, aritmetik ortalama, standart sapma, tek yönlü varyans analizi testi ve t-testinden yararlanılmıştır.
Bulgular: Elde edilen verilere göre sporcuların karakter düzeylerinin yüksek olduğu görülmüştür. Cinsiyete göre anti-sosyal davranış alt boyutunda kızlar lehine istatistiksel olarak anlamlı bir farkın olduğu görülmektedir. Sporla ilgilenilen süre, yaş düzeyleri ve milli sporcu olma değişkenleri açısından anlamlı farklılık tespit edilmemiştir. Ayrıca spor türüne göre dürüstlük alt boyutunda bireysel spor ile uğraşanlar lehine anlamlı bir farkın olduğu görülmüştür.
Sonuç: Bu araştırmanın sonucunda; sporcuların karakter düzeylerinin cinsiyete göre anti-sosyal davranış alt boyutunda ve spor türüne göre ise dürüstlük alt boyunda anlamlı farklılığın olduğu, sporla ilgilenilen süreleri, yaşları ve milli sporcu olma durumlarına göre anlamlı bir farklılığın olmadığı belirlenmiştir.
Experiential Mobile Learning: QR Code Driven Strategy in Teaching Thermodynamics in Science 12
Authors: Serrano Arman 
Published: December 2023

The purpose of this study was to examine whether QR code driven strategy would be effective in teaching thermodynamics in science 12. Experimental design was used to test the effectiveness of the strategy. Further, pretest-post- test design was employed wherein one section from grade 12 STEM strand was exposed to the intervention while the other section was exposed to traditional approach. Both groups took the same pretest-post-test which was composed of 50 multiple choice questions. The test questionnaire used was validated using Zipgrade application to determine the discrimination and difficulty index. Moreover, test scores were subjected to Cronbach’s Alpha for reliability test. Weighted mean was computed to describe the test scores of both controlled and experimental groups. T-test of difference between means of independent samples were used to determine the difference between the means of two groups and were tested at 0.05 level of significance. Results revealed that the two groups under study did not differ significantly in their pretest, which means that the students’ knowledge before the intervention were about at the same level. In contrast, based on the statistical analysis, the t-test significantly differentiated the two groups in favor of the experimental group, which registered higher means in the posttest. This means that after the learning units using the QR code driven strategy, the experimental group was greatly improved in the posttest. Together, these findings also suggest that the two groups exhibited significant difference in their pretest and posttest but the QR code driven strategy effects to be predominant.
Antagonistic effect of Cry1Ac and Cry1Jb on cotton bollworm (Helicoverpa armigera)
Authors: CHELLIAH ANURADHA , GUPTA GORAKH PRASAD , KARUPPIAH SASIKUMAR , KUMAR POLUMETLA ANANDA 
Published: December 2023

The interaction of two crystal proteins, Cry1Ac and Cry1Jb was evaluated against cotton bollworm (Helicoverpa armigera). The 50% lethal concentrations (LC50s) were estimated to be 2.29 ng/ml and 6 039 ng/ml for Cry1Ac and Cry1Jb, respectively. When mixtures of these toxins in different proportion were assayed, the expected LC50s were lower than the observed LC50s, indicating a clear antagonism between the two toxins. Ligand blotting showed that both the toxins bind to 110kDa APN corroborating the results. This is the first report of antagonism of Cry1Jb with Cry1Ac toxin against cotton bollworm. This trait may prove useful for combating insecticide resistance and for improving the activity of microbial insecticides.
Genetic diversity analysis for moisture stress adaptive and quality traits in bread wheat (<i>Triticum aestivum</i>)
Authors: KALLESH D T , SINGH G P , SINGH ANJU M , AHLAWAT ARVIND , SHARMA R K 
Published: December 2023

A study was conducted to work out the genetic divergence for yield, morpho-physiological and quality traits in timely sown restricted irrigated and rainfed conditions. In the pooled analysis, cluster IV and V had 33 genotypes each and cluster III contained 29 genotypes, while cluster VI had 22 genotypes. Eighteen and 15 genotypes were included in cluster I and II, respectively. Maximum intra-cluster distance was reported in cluster III followed by VI, II, I and IV and minimum intra- cluster distance was found for cluster V. Genotypes included in III, VI and II revealed maximum diversity among themselves. Highest inter-cluster distance was observed between cluster II and III followed by I and III, I and VI. Moderate inter-cluster distance was noticed between II and IV in the pooled analysis. Parentage of 150 genotypes revealed that genotypes were belonging to different eco-geographical areas were included in the same cluster. This indicated that there is no association between clustering pattern and eco- geographical distribution of genotypes.
Effect of pre-harvest application of NAA and potassium nitrate on storage quality of winter guava (<i>Psidium guajava</i>)
Authors: MANDAL GOUTAM , DHALIWAL H S , MAHAJAN B V C 
Published: December 2023

A study was conducted at Punjab Agricultural University, Ludhiana during 2006–08 in winter crop of guava cv. Sardar to evaluate the influence of pre-harvest foliar application of naphthalene acetic acid (NAA) and potassium nitrate on quality attributes in different interval of cold storage. The plants were sprayed with NAA and potassium nitrate at colour break stage of fruit and harvested at optimum maturity, packed in CFB boxes with newspaper lining and stored at 6- 8oC and 90-95% RH. Fruits treated with NAA (100 ppm) effectively reduced spoilage maintained higher fruit firmness, TSS and ascorbic acid and remain slightly desirable after 30 days of storage. Thus, pre-harvest spray with NAA (100 ppm) seems to be effective method for decreasing post- harvest losses and maintaining quality of guava fruits.
Generalized Additive Functional Equation: General Solution and Hyers-Ulam Stability in Banach Spaces via Alternative Fixed Point Theorem
Authors: Tamilvanan Kandhasamy , Mohiuddine Syed Abdul 
Published: December 2023

In this paper, we secure the general solution of the generalized additive functional equation
[Equation presented]
where r is a positive integer with N−{0,1,2,3,4}, and also examine Hyers-Ulam stability results by utilizing alternative fixed point for a generalized additive functional equation in Banach spaces.
(شانۆ و شیعری شانۆیی له‌ بواری فێركردن)دا شیعره‌ شانۆییه‌كانی شوان ئه‌حمه‌د به‌ نموونه‌
Authors: هێرۆ عەبدولڕەحمان مستەفا  , عومه‌رصالح عومەر 
Published: December 2023

ئه‌م توێژینه‌وه‌یه‌ به‌ ناونیشانی (شانۆ و شیعری شانۆیی لە بواری فێرکردن) دایه‌. شيعره‌ شانۆییەکانی شوان ئه‌حمه‌د به ‌نموونه وه‌رگیراوه‌‌. هه‌وڵێكه‌ بۆ ناساندنی شانۆ و شیعری شانۆیی منداڵان، هه‌وڵمان داوه‌ كاریگه‌رییه‌كانی ئه‌مجۆره‌ شیعره‌ له‌‌ ڕووی په‌روه‌ردەیی‌ و فێركردن له ‌سه‌ر منداڵان ڕوون بكه‌ینه‌وه‌، كە كەناڵێكی هەرە گرنگی پێگەیاندنی كۆمەڵایەتییە، لە ڕێگەیەوە منداڵان بۆ ژیانی نێو كۆمەڵگا ئامادە دەكرێن. شانۆ و شیعری منداڵانیش فاكتەرێكی گرنگی پەروەردە و فێركردنە، كاریگەری گەورەی لە گەشەپێدانی كەسایەتی منداڵان و ڕۆشنبیركردن و فراوان بوونی ئاسۆی بیركردنەوەیان هەیه‌، بەتایبەتی لە قۆناغەكانی باخچە و خوێندنی بنەڕەتی. لەو ڕێگەیەوە دەتوانرێت پەیامی پەروەردەیی باشتر بكات و فێركردن چالاكتر ببێت، چونكە لەو قۆناغەدا منداڵان زیاتر لە ڕێگەی بینین و لاسیكردنەوەوە فێردەبن، تا چەندیش ئەوەی دەیبینێت سەرنجڕاكێشتر بێت، زیاتر چێژی پێ دەبەخشێت و زووتر وەردەگرێت و لاسایی دەكاتەوە. منداڵان لە شانۆ و شیعری شانۆیی بە بەشداری كردن، یاخود بینینی چێژ و خۆشی وەردەگرن، ئەمەش وادەكات فاكتەرێكی فێركردنی كاریگەر بێت، بۆ گەیاندنی هەر پەیام مەبەستێك بە منداڵان لەو قۆناغەدا. ئەم توێژینەوەیە كاریگەرییە پەروەردەیی و فێركارییەكانی شیعری شانۆیی (ژینگە و پاڵەوانی جەنگەڵ)ی شوان ئەحمەدی دەرخستووە، لەگەڵ هەموو ئەو لێكەوتانەی لەسەر منداڵ هەیەتی. توێژینەوەیەكە لە پێشەكی و دوو بەش پێكهاتووە.
به‌ره‌نگاری و ڕه‌نگدانه‌وه‌ی له‌ شیعره‌كانی- كامران موكری- دا
Authors: سه‌رحه‌د حوسێن مسته‌فا  , عوسمان عه‌بدول مه‌عروف به‌رزنجی  
Published: December 2023

ئه‌م بابه‌ته‌ ئاماژ به‌وه‌ ده‌كات، كه‌ پێكهاته‌ی كۆمه‌ڵگای مرۆڤایه‌تی به‌ پێی گه‌لان و نه‌ته‌وه‌كان جیاوازه‌، چونكه‌ لای میلله‌تانی سه‌رده‌سته‌ زۆر سته‌م و ناڕه‌وایی هه‌یه‌، كه‌ ده‌رحه‌ق به‌ میلله‌تانی ژێرده‌سته‌ ده‌كرێت و لای ئه‌وان به‌دی ناكرێت، وه‌كو جیاوازی نه‌ته‌وایه‌تی و زوڵم و سته‌می ناڕه‌وا، كه‌ به‌رامبه‌ر به‌نه‌ته‌وه‌ بن ده‌ده‌سته‌كان ده‌كرێت، به‌تایبه‌تی له ‌ده‌سه‌ڵاته‌ شۆڤێنی و ره‌گه‌ز په‌رسته‌كاندا.
به‌ڵام به‌نسبه‌ت جیاوازی چینایه‌تییه‌وه‌، له‌زۆربه‌ی ده‌سه‌ڵاته‌كاندا، ئه‌وه‌ به‌دی ده‌كرێت، هه‌ر چه‌ند پرۆپاگه‌نده‌ی مرۆڤدۆستی ده‌كه‌ن.
ناونیشانی باسه‌كه‌ ((به‌ره‌نگاری و ره‌نگدانه‌وه‌ی له‌شیعره‌كانی كامه‌ران موكری)) یه‌و له‌سێ باسی سه‌ره‌كی پێكدێت :
باسی یه‌كه‌م: به‌ره‌نگاری كلتوری:
باس له ‌كلتور و داب و نه‌ریتی كۆمه‌ڵایه‌تی و ئایینی ده‌كات، كه‌ له‌لای هه‌ندێ له‌ شاعیر و رۆشنبیره‌كان، كۆمه‌ڵێ له‌و زوڵم و سته‌مه‌ی به‌ناوی ئایین و داب و نه‌ریته‌وه‌ لێیان ده‌كرێت، كه‌ دوورن له ‌هه‌موو به‌هایه‌كی ئایینی و مرۆڤایه‌تییه‌وه‌. به‌ڵام له ‌هه‌مانكاتدا، ئه‌و داب و نه‌ریته‌ نه‌ته‌وایه‌تییانه‌ی، كه‌ ره‌نگدانه‌وه‌ی بنه‌ما و بوونی نه‌ته‌وه‌ن، لایان رۆشن ده‌كه‌نه‌وه‌ و به‌ پیرۆزی، هه‌ڵیان ده‌سه‌نگێنن.
باسی دووه‌م: به‌ره‌نگاری داب و نه‌ریت له‌ هۆنراوه‌كانی –كامه‌ران-دا :
له‌م ته‌وه‌ره‌دا، شاعیر زۆر به‌توندی هه‌ندێ له‌و داب و نه‌ریتانه‌ ره‌تده‌كاته‌وه‌، كه‌ له‌به‌رژه‌وه‌ندی چینێك، یان كۆمه‌ڵه‌ كه‌سێك، سه‌پێنراون به‌سه‌ر زۆربه‌ی كۆمه‌ڵگادا، به‌زمانی زبر و به‌هه‌ڵوێسته‌ مرۆڤدۆست و نه‌ته‌وه‌ییه‌كه‌ی خۆی به‌رپه‌چیان ده‌داته‌وه‌ و خه‌ڵكی لێ هۆشیار ده‌كاته‌وه‌، تا به‌ره‌نگاریان ببنه‌وه‌.
باسی سێیه‌م: به‌ره‌نگاری جیاوازی چینایه‌تی نه‌ته‌وایه‌تی:
-كامه‌ران-ی شاعیر، جوامێرانه‌ هه‌ڵوێست و به‌ره‌نگاری توندی نواندووه‌ به‌رامبه‌ر هه‌ر زوڵم و سته‌مێك، كه‌ رووبه‌رووی نه‌ته‌وه‌كه‌ی بۆته‌وه‌، جا ئیتر كێشه‌ی چینایه‌تی بێت، یاخود كێشه‌ و گرفته‌ نه‌ته‌وایه‌تییه‌كان بێت، چونكه‌ هه‌رگیز وه‌ك سه‌یركه‌ر نه‌یڕوانیوه‌ته‌ چه‌رمه‌سه‌رییه‌كانی نه‌ته‌وه‌كه‌ی، به‌ڵكو هه‌میشه‌ به‌گژ هه‌موو نادادییه‌كدا چۆته‌وه‌ و چه‌نده‌ها جار زیندانیكردنی، گه‌واهی ئه‌و راستیانه‌ن.
PLEVNE MUHAREBESİ’NİN ALLGEMEİNE GAZETESİ’NDEKİ YANSIMASI
Authors: TEMİZSOY Zeynep , ALAN Gülbadi 
Published: December 2023

Osmanlı-Rus Savaşı, 1877-1878 yıllarında gerçekleşen ve tarihî kaynaklarda "93 Harbi" olarak kaydedilen, Osmanlı İmparatorluğu ve Rus İmparatorluğu arasında geçen kapsamlı bir çatışma dönemidir. Bu tarihi olayların içinde öne çıkan kritik bir mesele ise Plevne Muharebesi'dir. Osmanlı Devleti, Rus İmpara-torluğu'nun genişleme isteklerine karşı koymak ve Balkanlar'a doğru ilerleyen Rus kuvvetlerinin güçlenmesini önlemek amacıyla Tuna Cephesi'nde stratejik bir savunma planı geliştirmiştir. Bu savunma planının uygulanmasında ise dö-nemin Tuna Cephesi başkomutanı olarak Gazi Osman Paşa görevlendirilmiştir. Gazi Osman Paşa'nın liderliğindeki direniş, Osmanlı Devleti'nin Plevne şehrin-deki son savunma hattını temsil ederek, Rus işgaline karşı gösterilen kararlı bir direnişi sembolize etmektedir.
Almanya'nın önde gelen siyasi ve kültürel yayın organı olan Allgemeine Ga-zetesi, bu tarihi süreci yakından takip etmiş ve özellikle Plevne Muharebesi'nin Alman basınındaki etkilerini ayrıntılı bir şekilde belgelemiştir. Bu bağlamda, Balkanlar'daki genel durum, Rus ve Osmanlı ordularının stratejik konumu, be-nimsenen stratejiler ve Plevne'nin sonuçları gibi kritik olaylar, derinlemesine bir kronolojik sıra içinde incelenmiş ve detaylı bir analizle ele alınmıştır.
The Effect of Web Quality, Customer Retention and Switching Barrier on Customer Loyalty Through Customer Satisfaction
Authors: Haris Abdul 
Published: December 2023

Tokopedia is one of the online shopping portals that has existed since 2009 until now the name of Tokopedia is getting bigger and known by many people in Indonesia, but over time and technological developments in Indonesia, more and more of these other online shopping portals have an impact on the variety of choices among the public as other choices and can compare which one is the most value for money to be made the main choice as a means of online shopping. But in the end, not a few of these online shop companies finally decided to close their portals in Indonesia because of the very high competitive level and difficulty in getting loyal customers. Until the peak when the pandemic occurred which reduced the level of people's purchasing power, several online shops began to close their networks in Indonesia. This study aims to determine the effect of web quality, customer retention and switching barrier through customer satisfaction on customer loyalty. The population in this study is employees of PT Solusi Transportasi Indonesia with the number of samples in this study amounting to 100 employees who have become users of the Tokopedia application at least have placed orders. Purposive sampling techniques with data collection are carried out using questionnaires in Gform format which are then processed using SmartPLS 4.0 software using SEM (Structural Equation Modeling) models. The results showed that directly variable X (Quality Web, Customer Retention and Switching Barrier) had a positive and significant effect on variable Z (Customer Satisfaction) but the independent variable or X (Quality Web, Customer Retention and Switching Barrier) had a positive value but not significant to Y (Customer Loyalty), but when variable X (Quality Web, Customer Retention, Switching Barrier) mediated by variable Z (Customer Satisfaction) had results positive and significant
Ratlarda siklofosfamid kaynaklı kardiyotoksisite üzerine timokinonun etkileri
Authors: YANILMAZ Elif Merve Betül , MEMİ Gülsün , ANNAÇ Ebru , KAYA Mehmet Salih 
Published: December 2023

Amaç: Antineoplastik kemoterapide kullanılan bir ajan olan siklofosfamidin (CP) birçok doku üzerinde toksik etkisi bulunmaktadır. Bu çalışmada siklofosfamidin oluşturduğu kardiyotoksisiteye karşı çörek otu uçucu yağının baskın bileşeni olan Timokinonun (TQ) koruyucu etkileri araştırıldı.
Materyal ve Metot: Bu amaçla 32 adet 8 haftalık erkek Sprague Dawley sıçan 4 eşit gruba ayrıldı (n=8). Kontrol, TQ (10 mg/kg/gün, oral gavaj), CP (50 mg/kg, i.p., 1, 8, 15 ve 22. günlerde) ve TQ+CP (TQ 10 mg/kg/gün, oral gavaj ve CP 50 mg/kg, i.p., 1, 8, 15 ve 22. günlerde). Dört haftalık uygulamaların ardından kalp dokusunda histopatolojik ve biyokimyasal analizler yapıldı.
Bulgular: Kalp dokusunda CP’nin malondialdehit (MDA) seviyelerinde belirgin artışlara sebep olduğu (p
Monitoring the Cardiotoxic Effects of Bedaquiline in Older Children and Adolescents with Multiple and Extensive Drug Resistance
Authors: Piskunova O. A. , Panova L. V. , Bereznitskaya V. V. , Ovsyankina E. S. , Krushinskaya E. A. 
Published: December 2023

The objective: to evaluate expanded monitoring of cardiovascular disorders in older children and adolescents with multiple drug resistant tuberculosis receiving bedaquiline (Bq) as a part of anti-tuberculosis therapy.Subjects and Methods: A cohort retrospective-prospective study (2015-2021) was conducted, which included 36 patients aged 13-17 years old who received Bq. The prospective part included 19 patients (Main Group), they underwent extended monitoring (EM) of cardiotoxic reactions; this extended monitoring program was developed in Central Tuberculosis Research Institute. The retrospective part included 17 patients (Control Group), in whom cardiotoxic reactions were assessed using standard monitoring recommended by the Russian Society of Phthisiologists at that time. The relationship between the studied risk factor (monitoring by standard ECG) and the outcome (Bq discontinuation) was assessed using the Pearson χ2 test.Results. Prolongation of the QTc interval > 0.440 ms was noted in 17.6% of cases in Control Group and it was regarded as a cardiotoxic effect of Bq, the drug was discontinued. In Main Group, prolongation was noted in 47.3% of cases which was considered a functional disorder of the cardiovascular system according to EM, the drug was not discontinued, χ2 = 3.896; p = 0.049. EM can be used in older children and adolescents with multiple drug resistant respiratory tuberculosis, which will make it possible to safely include Bq to chemotherapy regimens.
Cellular Therapy with Autologous Mesenchymal Stromal Cells in Patients with Drug Resistant Pulmonary Tuberculosis
Authors: Solodovnikova V. V. , Skryagin A. E. , Isaykina Y. I. , Klimuk D. A. , Gurevich G. L. , Skryagina E. M. 
Published: December 2023

The objective: to evaluate the effectiveness of treatment with autologous mesenchymal stromal cells (MSCs) in patients with drug resistant pulmonary tuberculosis (DR TB).Subjects and Methods. 120 patients with drug resistant tuberculosis aged 18 to 61 years old were enrolled in the study. They all were treated at the Republican Scientific and Practical Center of Pulmonology and Phthisiology from 2009 to 2018. Against the background of anti-tuberculosis treatment, patients (60 people) from Main Group (MG) underwent bone marrow sampling and then intravenous administration of autologous MSCs.Results. The average dose of administered cells was 1x106 per kg of the patient body weight. The average duration of MSC cultivation made 35 days. Treatment effectiveness in MG made 90% versus 71% in Control Group (CG). All patients who were successfully cured of tuberculosis (TB) using autologous MSCs had no tuberculosis relapses during 5 years of follow-up. In Control Group, 8 (19%) cases of relapse were reported. In Main Group versus Comparison Group, the rates indicating healing of cavities and absence of relapse are statistically significantly better.Conclusion. The use of autologous MSCs in patients with drug resistant tuberculosis has shown its high effectiveness.