bluuebunny/crossref_metadata_2025_split huggingface dataset:
Association of dietary inflammatory index and all-cause and cardio- cerebrovascular mortality in atherosclerotic cardiovascular disease survivors: a cohort study from NHANES analysis
Authors: Tan Yuhao , Chen Rundong , Zhang RenKun , Dai Dongwei , Zhang Yongwei , Li Qiang , Zhao Rui , Xu Yi , Huang Qinghai , Yang Pengfei , Zuo Qiao , Liu Jianmin 
Published: October 2023

Abstract
Objective
To evaluate the association between dietary inflammatory index (DII) and all-cause and cardio-cerebrovascular mortality in patients with atherosclerotic cardiovascular disease (ASCVD).
Methods
We collected data from National Health and Nutrition Examination Survey (NHANES) between 1999 and 2018. The chi-square test was performed to evaluate the association between pro-inflammatory diets (DII > 0) and anti-inflammatory diets (DII < 0) participant groups. Cox regression models were used to investigate the association between DII and all-cause and cardio-cerebrovascular mortality. We also used a restricted cubic spine RCS model to explore the possible non-linear association between DII and mortality. Meanwhile, we investigated the potential interaction between multiple stratification factors and DII.
Results
A total of 4264 participants with 58.75% were male included, of which 3201 were over 60 years old. During the median follow-up period of 83 months, a total of 1784 participants had died from any cause. All-cause mortality of the pro-inflammatory diet group (38.26%) was significantly higher than the anti-inflammatory diet group (30.95%). In three models, DII was significantly associated with an elevated risk of cardio-cerebrovascular mortality. We developed RCS models and found evidence of a non-linear correlation between DII and all-cause mortality and cardio-cerebrovascular mortality, P for non-linearity was 0.048 and 0.008, respectively. Finally, we analyzed the DII across risk factor subgroups linked to stroke, and no significant disparities were identified.
Conclusion
Our study revealed a protential non-linear association between DII and all-cause mortality and cardio-cerebrovascular mortality in ASCVD survivors.
Application of Transrectal Contrast-enhanced Ultrasound Imaging-based Radiomics Model in Predicting the Efficacy of Neoadjuvant chemoradiotherapy for Locally Advanced Rectal Cancer
Authors: Liao Zhongfan , Gao Chenghao , Yang Yin , Luo Yuan , Yin Hao , Zhang Yonggang , Zhuang Hua 
Published: October 2023

Abstract

Background
Predicting tumor regression grade (TRG) after neoadjuvant chemoradiotherapy (NCRT) in patients with locally advanced rectal cancer (LARC) before surgery accurately can help to provide an individualized treatment plan. However, the predictive efficacy of traditional imaging modalities is unsatisfactory. Radiomics based on transrectal contrast-enhanced ultrasound (TR-CEUS) imaging may provide promising prediction results.
Methods
A total of 190 patients with LARC who underwent NCRT and subsequent total mesorectal excision were included. Based on the pathological TRG, patients were divided into the good response group (TRG 0 and 1, n = 53) and poor response group (TRG 2 and 3, n = 137). TR-CEUS examinations before and after NCRT were performed on these patients. With 10-fold cross validation, machine learning (ML) models for predicting the efficacy of NCRT were trained and established based on seven classifiers, including support vector machine, auto-encoder (AE), linear discriminant analysis, random forest (RF), logistic regression, logistic regression via Lasso or gaussian process. Predictive performances between different models were evaluated by receiver operating characteristic (ROC) curve analyses, including sensitivity, specificity, accuracy, area under the curve (AUC), 1-SE rule and Delong test.
Results
A total of 1525 TR-CEUS images were included for analysis and 3360 ML models were established before and after NCRT respectively. Based on the AUC and 1-SE rule, two optimal ML models were selected before and after NCRT respectively, including AE and RF. The AUC values of AE and RF models after NCRT were 0.86 and 0.84 in the cross validation set and were 0.83 and 0.84 in the testing set. The differences between RF models (D = -7.00, P < .001 for cross validation set and D = -2.04, P = .042 for testing set) and AE models (D = -7.40 for cross validation set and D = -6.68 for testing set, P < .001 for both) before and after NCRT were both statistically significant.
Conclusions
Radiomics models based on post-NCRT TR-CEUS images has a high predictive performance for TRG of LARC, which could accurately predict the NCRT efficacy in patients with LARC relatively.
Potential role of Fbxo22 in resistance to endocrine therapy in breast cancer with invasive lobular carcinoma
Authors: Nakagawa Saki , Miyashita Minoru , Maeda Ichiro , Goda Atsushi , Tada Hiroshi , Amari Masakazu , Kojima Yasuyuki , Tsugawa Koichiro , Ohi Yasuyo , Sagara Yasuaki , Sato Miku , Ebata Akiko , Harada-shoji Narumi , Suzuki Takashi , Nakanishi Makoto , Ohta Tomohiko , Ishida Takanori 
Published: October 2023

Abstract
Background
Invasive lobular carcinoma (ILC) is distinct from invasive ductal carcinoma (IDC) in terms of their hormonal microenvironments that may require different therapeutic strategies. We previously reported that selective estrogen receptor modulator (SERM) function requires F-box protein 22 (Fbxo22). Here, we investigated the role of Fbxo22 as a potential biomarker contributing to the resistance to endocrine therapy in ILC.
Methods
A total of 302 breast cancer (BC) patients including 150 ILC were recruited in the study. Fbxo22 expression and clinical information were analyzed to elucidate whether Fbxo22 negativity could be a prognostic factor or there were any correlations among clinical variables and SERM efficacy.
Results
Fbxo22 negativity was significantly higher in ILC compared with IDC (58.0% vs 27.0%, P < 0.001) and higher in postmenopausal patients than premenopausal patients (64.1% vs 48.2%, P = 0.041). In the ILC cohort, Fbxo22-negative patients had poorer overall survival (OS) than Fbxo22-positive patients, with 10-year OS rates of 77.4% vs. 93.6% (P = 0.055). All patients treated with SERMs, Fbxo22 negativity resulted in a poorer outcome, with 10-year OS rates of 81.3% vs. 92.3% (P = 0.032). In multivariate analysis regarding recurrence-free survival (RFS) in ILC patients, Fbxo22 status was independently predictive of survival as well as lymph node metastasis.
Conclusion
Fbxo22 negativity significantly impacts on survival in BC patients with IDC and ILC, and the disadvantage was enhanced among ILC postmenopausal women or patients treated with SERMs. The findings suggest that different therapeutic strategies might be needed according to the different histopathological types when considering adjuvant endocrine therapy.
Characterization and structure of trans, trans, trans-1,3,5,7-tetrakis(3ʹ,3ʹ,3ʹ- trifluoropropyl)-1,3,5,7-tetramethylcyclotetrasiloxane, and structure of trans-1,3,5- (3ʹ,3ʹ,3ʹ-trifluoropropyl)-1,3,5-trimethylcyclotrisiloxane
Authors: Leman John , Gibson James , Bonitatibus Peter 
Published: October 2023

Abstract
One of four possible stereoisomers of a methyl(trifluoropropyl)siloxane cyclic tetramer was isolated from low molecular weight volatiles, formed in a reaction mixture during ring-opening/equilibration polymerization of methyl(3,3,3-trifluoropropyl)cyclotrisiloxane (D3F). The crystalline solid was recognized as resembling a previously isolated cyclic siloxane with undetermined stereochemistry, assigned as a cyclotetrasiloxane by IR spectroscopy, and then further characterized by multinuclear (1H, 13C, 19F, and 29Si) NMR spectroscopy as a relatively high symmetry species with respect to the potential cis-trans relationships of the methyl and 3,3,3-trifluoropropyl substituents at Si. Unambiguous characterization and assignment of the stereochemistry was accomplished by a single crystal X-ray diffraction study, which revealed the compound was the trans, trans, trans-isomer, one species in these equilibration polymerization mixtures. The single crystal X-ray structure of the related, commercially important trans-D3F cyclotrisiloxane has also been determined. The structures of the two cyclic fluorinated siloxanes are discussed with respect to each other, and in the context of prototypical structures for these common Si3O3 and Si4O4 ring systems.
Ventriculostomy and Lumbar Drain Management Training: A Randomized Trial of Computer-Based Training vs Self-Directed Video-Based Practice
Authors: Ricks Cameron , Brammeier Jereme , Beaulieu Keith , Field Ryan , Banh Esther , Nelson Corey , Schmitt Kenneth , Ha Abraham , Pham Nicholas , Miller Robert , Rinehart Joseph 
Published: October 2023

Abstract

Purpose: Anesthesiology residents manage external ventricular drains (EVD) or lumbar drains (LP) in the operating room. There is no specific curriculum for anesthesiology residents on these devices. Computer-based training (CBT) utilizes reading material, photos, and questions without interactive content. Self-directed video-based practice (SVP) introduces hands-on training guided by a video example.
Methods: A randomized single-blinded prospective trial was executed to compare the educational efficacy of SVP to CBT in managing EVD/LP by anesthesiology resident physicians. Simulation-based assessment was utilized for resident evaluation pre-intervention and at 2 weeks and 3 months post-intervention.
Results: Linear regression showed a non-significant difference between the SVP group and the CBT group on performance (p=0.54). Compared to baseline scores, post-training test scores increased by an average of 22% (47 ± 26 vs. 69 ± 21; p<0.0001, 95% CI 16 – 28) points for pre- vs. post-training). A Spearman's comparison correlation demonstrated a high degree of correlation between the Total score and the Global performance ratings (r2 = 0.83, p<0.0001; 95% CI 0.75 – 0.89).
Conclusion: CBT and SVP improved performance in managing ventriculostomies and lumbar drains in a simulated environment. There was no statistically significant difference between the CBT and SVP groups nor between post-test 1 and post-test 2. The validation measurement for simulation-based assessment was reliable and had strong evidence of validity.
Normal stress distribution in built-up cold-formed column in relation to interconnecting bolt spacing
Authors: Deniziak Patryk , Gordziej-Zagórowska Małgorzata , Urbańska-Galewska Elżbieta 
Published: October 2023

Abstract
In order to increase a stiffness of cold-formed steel (CFS) elements it is practised to built-up the cross-section. In the analysed case, main element is strengthened by adding extra chord in contact partially along the column. This additional chord acts as a longitudinal stiffener connected with a main section by series of bolts. Authors check whether applied over the years rules for hot-rolled elements can be indiscriminately used in the analysed CFS element. The aim of this study is to experimentally and computationally recognize the normal stress distribution in axially compressed CFS built-up column chords and to evaluate the element load-bearing capacity.
A qualitative study of postoperative experience and needs of laparoscopic sleeve gastrectomy patients: a social-ecological system theory perspective
Authors: Gao Yaxin , Zhang Peng , Jin Chengcheng , Zhu Li 
Published: October 2023

Abstract
Objective This study aims to explore the postoperative experiences and social support of patients who underwent laparoscopic sleeve gastrectomy, analyze their negative experiences, improve self-care levels, reduce negative emotions, refine the effectiveness of bariatric procedures, and enhance the quality of life, providing a basis for further improving the quality of medical care services and the social support system for this patient population.
Methods A qualitative research method was used utilizing the social-ecological system theory. Semi-structured interviews were conducted with 20 patients who underwent laparoscopic sleeve gastrectomy between January 1 and December 31, 2022. Colaizzi's phenomenological 7-step analysis was used to analyze the interview data.
Results The postoperative experiences of bariatric surgery patients were categorized into three themes: microsystem (individual system) - the coexistence of health and distress; mesosystem (small group) - changes in family attitudes and positive roles of health care professionals and patients; macrosystem (social support) - limited societal acceptance of bariatric surgery and overall satisfactory financial support and health insurance reimbursement.
Conclusion This study provides a comprehensive understanding of the postoperative experiences of Chinese laparoscopic sleeve gastrectomy patients. Their real feelings were summarized at micro, meso, and macro levels, and corresponding solutions were given according to patients' negative experiences. A multidisciplinary cooperative case management model should be adopted after laparoscopic sleeve gastrectomy to provide individualized nutritional exercise guidance and continuous health follow-up for post-bariatric surgery patients to improve patients' negative experiences and enhance weight loss results. Besides, a web-based online group could provide psychological support and serve as a health communication platform for this patient population. Moreover, increasing awareness and education about bariatric surgery should be emphasized to foster greater support and recognition from family, friends, and society.
Larval precompetency and settlement behaviour in 25 Indo-Pacific coral species
Authors: Randall Carly , Giuliano Christine , Stephenson Briony , Whitman Taylor , Page Cathie , Treml Eric , Logan Murray , Negri Andrew 
Published: October 2023

Abstract
Knowledge of coral larval precompetency periods and maximum competency windows is fundamental to understanding coral population dynamics, informing biogeography and connectivity patterns, and predicting reef recovery following disturbances. Yet for many species, estimates of these early-life history metrics are scarce and vary widely. Furthermore, settlement cues for many taxa are not known despite consequences to habitat selection. Here we performed a comprehensive experimental time-series investigation of larval settlement behaviour, for 25 ecologically significant broadcast-spawning species. To investigate the duration of precompetency, improve predictions of the competency windows, and compare settlement responses within and amongst species, we completed replicated and repeated 24-hour assays that exposed larvae to five common settlement cues. Our study revealed that larval competency in some broadcast-spawning species begins as early as two days post fertilisation, but that the precompetency period varies within and between species from about two to six days, with consequences for local retention and population connectivity. We also found that larvae of some species are competent to settle beyond 70 days old and display complex temporal settlement behaviour, challenging the assumption that competency gradually wanes over time and adding to the evidence that larval longevity can support genetic connectivity and long-distance dispersal. Using these data, we grouped coral taxa by short, mid and long precompetency periods, and identified their preferred settlement cues. Taken together, these results inform our understanding of larval dynamics across a broad range of coral species and can be applied to investigations of population dynamics, connectivity, and reef recovery.
A novel R2R3-MYB transcription factor PbMYB1L of Pyrus bretschneideri regulates cold tolerance and anthocyanin accumulation
Authors: Zhou Xuan , Lei Diya , Yao Wantian , Li shangyun , Wang Haiyan , Lu Jiayu , Zhang Yunting , Lin Yuanxiu , Wang Yan , He Wen , Li Mengyao , Chen Qing , Luo Ya , Wang Xiaorong , Tang Haoru , Zhang Yong 
Published: October 2023

Abstract
MYB transcription factors (TFs) have been demonstrated to play diverse roles in plant growth and development. In the present study, we identified a novel R2R3-MYB transcription factor, PbMYB1L, from the peel of 'Red Zaosu' pear (Pyrus bretschneideri), which was induced by cold stress and acted as a positive regulator in anthocyanin biosynthesis. Notably, the transgenic Arabidopsis lines exhibited enhanced tolerance to cold stress. Compared to the Arabidopsis wild-type plants, the transgenic lines displayed increased chlorophyll levels, longer primary roots, and reduced reactive oxygen species (ROS) levels including O2-, hydrogen peroxide (H2O2), and malondialdehyde (MDA). Furthermore, significant upregulation of key cold-responsive genes AtCBF1, AtCBF2, AtCBF3, AtCBF4, and AtKIN1 was observed in the transgenic plants under cold stress conditions compared to wild type. Arabidopsis plants overexpressing PbMYB1L had significant anthocyanin accumulation in leaves after cold treatment with quantitative results indicating higher expression of anthocyanin structural genes compared to wild type. These finding suggests that PbMYB1L not only plays a vital role in conferring cold tolerance but also acts as a crucial regulator of anthocyanin biosynthesis.
Fourier spectral exponential time-differencing method for a space-fractional generalized wave equation
Authors: Mohammadi S. , Fardi M. , Ghasemi M. , Hendy A. S. , Zaky M. A. 
Published: October 2023

Abstract

This manuscript deals with a space-fractional generalized wave problem involving the fractional Laplacian operator of order α for 1 < α ≤ 2. We propose an accurate numerical method to solve the mentioned fractional wave problem. The problem is discretized in spatial direction by the Fourier spectral method, and in temporal direction by utilizing the fourth-order exponential time-differencing Runge-Kutta (ETDRK4) method. One of the main features of this method is to reduce the mentioned fractional wave model to an ODE by using the Fourier transform, and then the ETDRK4 method is used to solve this ODE. We define the discrete energy function and check the energy-conserving properties. The convergence of this method is proved. Various numerical experiments are conducted to confirm the accuracy and dependability of the suggested approach.
The use of social simulation modelling to understand adherence to diabetic retinopathy screening programs
Authors: Pereira Andreia Penso , Macedo João , Afonso Ana , Laureano Raul M. S. , Neto Fernando Buarque Lima 
Published: October 2023

Abstract
The success of screening programs depends to a large extent on the adherence of the target population, so it is therefore of fundamental importance to develop computer simulation models that make it possible to understand the factors that correlate with this adherence, as well as to identify population groups with low adherence to define public health strategies that promote behavioral change. Our aim is to demonstrate that it is possible to simulate screening adherence behavior using computer simulations. This is the first article in the literature in which three versions of an agent-based model are presented simultaneously: a) Logistic regression to determine the individual decision to adhere to screening; b) Logistic regression is replaced by fuzzy logic components and c) A combination of the previous. All versions were calibrated and validated using real data from 271867 calls for diabetic retinopathy screening. The results obtained are statistically very close to the real ones, which allows us to conclude that despite having a high degree of abstraction from the real data, the simulations are very valid and useful as a predictive tool for health planning, both in implementing new screening programs and in identifying problem factors and improving existing interventions.
Sex-specific trends in incidence of myocardial infarction among people with and without diabetes between 1985 and 2016 in a German region
Authors: Claessen Heiner , Narres Maria , Heier Margit , Kvitkina Tatjana , Linkohr Birgit , Wolff Georg , Roden Michael , Icks Andrea , Peters Annette 
Published: October 2023

Abstract
Background
The reduction of myocardial infarction (MI) and narrowing the gap between the populations with and without diabetes are important goals of diabetes care. We analyzed time trends of sex-specific incidence rates (IR) of first MI (all, non-fatal MI, fatal event) in the population with and without diabetes.
Methods
Using data from the KORA myocardial infarction registry (Augsburg, Germany), we estimated age-adjusted IR in people with and without diabetes, corresponding relative risks (RR), and time trends from 1985 to 2016 using Poisson regression.
Results
There were 19,683 people with MI (34% fatal events, 71% men, 30% with diabetes). In the entire study population, the IR of all MI decreased from 359(95% CI: 345–374) to 236(226–245) per 100,000 person years. In men with diabetes, IR decreased only in 2013–2016. This was due to non-fatal MI, where IR in men with diabetes increased until 2009–2012, and slightly decreased in 2013–2016. Overall, fatal events declined stronger than non-fatal MI corresponding to IRs, the relative risk (RR) of all MI substantially increased among men from 1.40(1.22–1.61) in 1985–1988 to 2.60(2.26–2.99) in 1997–2000 and moderately decreased in 2013–2016: RR: 1.75(1.47–2.09). Among women no consistent time trend of RR was observed. Time trends of RR were similar regarding non-fatal MI and fatal events.
Conclusions
Over the study period, we found a decreased incidence of all MIs and fatal events in the entire study population. The initial increase of non-fatal MIs in men with diabetes needs further research. The gap between populations with and without diabetes remained.
Choosing the right system for cardboard wastewater treatment by chemical and electrical coagulation method using “analytical hierarchy process”(AHP)
Authors: sharabiani Hassan Mahmoudi , khalesi Mehran , Hassani Amirhessam , Vahedi Marjan , Moradi Zeinab 
Published: October 2023

Abstract
The objective of the present study was to compare the two systems of electrical coagulation and chemical coagulation in the treatment of waste water in cardboard industries. These two wastewater treatment methods were investigated with the help of analytical hierarchy process”(AHP). First, the research criteria were determined. These criteria included Economic, Efficiency, Energy consumption and Operation. Some criteria also had sub-criteria. After pairwise comparison and normalization of criteria, research options were weighted. The efficiency of these two methods to remove COD, TSS was investigated. The results showed that electric coagulation is higher than chemical coagulation in terms of efficiency with a weight of 0.75, economy with a weight of 0.737, Energy consumption with a weight of 0.667 and operation weight with a weight of 0.8. Finally, the electrical coagulation system was chosen as the final option with a weight of 0.74 and chemical coagulation as the second option with a weight of 0.26. In the treatment of cardboard waste, the consumption of chemicals is very high, so the electrocoagulation method can be very cost-effective. Also, operator error in this system was very low and work efficiency was higher.