bluuebunny/crossref_metadata_2025_split huggingface dataset:
The CD74 inhibitor DRhQ improves cognition and mitochondrial function in 5xFAD mouse model of Aβ accumulation
Authors: Gladen-Kolarsky Noah , Neff Cody J. , Hack Wyatt , Brandes Mikah S. , Wiedrick Jack , Meza-Romero Roberto , Lockwood Denesa R. , Quinn Joseph F. , Offner Halina , Vandenbark Arthur A. , Gray Nora E. 
Published: January 2024

AbstractNeuroinflammation and mitochondrial dysfunction are early events in Alzheimer’s disease (AD) and contribute to neurodegeneration and cognitive impairment. Evidence suggests that the inflammatory axis mediated by macrophage migration inhibitory factory (MIF) binding to its receptor, CD74, plays an important role in many central nervous system (CNS) disorders like AD. Our group has developed DRhQ, a novel CD74 binding construct that competitively inhibits MIF binding, blocks T-cell and macrophage activation and migration into the CNS, enhances anti-inflammatory microglia cell numbers and reduces pro-inflammatory gene expression. Here we evaluate its effects in β-amyloid (Aβ) overexpressing mice. 5xFAD mice and their wild type littermates were treated with DRhQ (100 µg) or vehicle for 4 weeks. DRhQ improved cognition and cortical mitochondrial function in both male and female 5xFAD mice. Aβ plaque burden in 5xFAD animals were not robustly impacted by DRhQ treatment nor was microglial activation, although in the hippocampus there was some evidence of a reduction in female 5xFAD mice. Future studies are needed to confirm this possible sex-dependent response on microglial activation as well as to optimize the dose, and timing of DRhQ treatment and gain a better understanding of its mechanism of action.
Highly Contiguous Genome Assembly ofDrosophila prolongata- a Model for Evolution of Sexual Dimorphism and Male-specific Innovations
Authors: Luecke David , Luo Yige , Krzystek Halina , Jones Corbin , Kopp Artyom 
Published: January 2024

AbstractDrosophila prolongatais a member of themelanogasterspecies group andrhopaloasubgroup native to the subtropical highlands of southeast Asia. This species exhibits an array of recently evolved male-specific morphological, physiological, and behavioral traits that distinguish it from its closest relatives, making it an attractive model for studying the evolution of sexual dimorphism and testing theories of sexual selection. The lack of genomic resources has impeded the dissection of the molecular basis of sex-specific development and behavior in this species. To address this, we assembled the genome ofD. prolongatausing long-read sequencing and Hi-C scaffolding, resulting in a highly complete and contiguous (scaffold N50 2.2Mb) genome assembly of 220Mb. The repetitive content of the genome is 24.6%, the plurality of which are LTR retrotransposons (33.2%). Annotations based on RNA-seq data and homology to related species revealed a total of 19,330 genes, of which 16,170 are protein-coding. The assembly includes 98.5% of Diptera BUSCO genes, including 93.8% present as a single copy. Despite some likely regional duplications, the completeness of this genome suggests that it can be readily used for gene expression, GWAS, and other genomic analyses.
Lattice QCD study of
πΣ−K¯N
scattering and the
Λ(1405)
resonance
Authors: Bulava John , Cid-Mora Bárbara , Hanlon Andrew D. , Hörz Ben , Mohler Daniel , Morningstar Colin , Moscoso Joseph , Nicholson Amy , Romero-López Fernando , Skinner Sarah , Walker-Loud André ,   Baryon Scattering (BaSc) Collaboration
Published: January 2024

A lattice QCD computation of the coupled channel πΣ–K¯N scattering amplitudes in the Λ(1405) region is detailed. Results are obtained using a single ensemble of gauge field configurations with Nf=2+1 dynamical quark flavors and mπ≈200  MeV and mK≈487  MeV. Hermitian correlation matrices using both single baryon and meson-baryon interpolating operators for a variety of different total momenta and irreducible representations are used. Several parametrizations of the two-channel scattering K-matrix are utilized to obtain the scattering amplitudes from the finite-volume spectrum. The amplitudes, continued to the complex energy plane, exhibit a virtual bound state below the πΣ threshold and a resonance pole just below the K¯N threshold.

Published by the American Physical Society
2024
Calculation of
cSW
at one-loop order for Brillouin fermions
Authors: Ammer Maximilian , Dürr Stephan 
Published: January 2024

The Brillouin action is a Wilson-like lattice fermion action with a 81-point stencil, which was found to ameliorate the Wilson action in many respects. The Sheikholeslami-Wohlert coefficient cSW of the clover improvement term has a perturbative expansion cSW=cSW(0)+g02cSW(1)+O(g04). At tree-level cSW(0)=r holds for Wilson and Brillouin fermions alike. We present the Feynman rules for the Brillouin action in lattice perturbation theory, and employ them to calculate the one-loop coefficient cSW(1) with plaquette or Lüscher-Weisz gluons. Numerically its value is found to be about half that of the Wilson action.

Published by the American Physical Society
2024
Patient, productivity, and quality representation in healthcare non-financial disclosure
Authors: Malmmose Margit , Skjøtt Linneberg Mai 
Published: January 2024

Purpose The objective of this study is to examine developments in the discursive practice of non-financial reporting in the public healthcare sector. In doing so, the authors investigate how the main reform foci of productivity and quality are represented, with a specific focus on the patient.Design/methodology/approachDrawing on critical discourse analysis (CDA), the authors conduct a longitudinal study (2007–2018) of healthcare reporting foci across the five administrative regions responsible for public hospitals in Denmark. The study analyses sixty annual reports and draws on contemporary reform documents over this period. CDA enables a micro-textual analysis, combined with macro-insights and discussions on social practice.Findings The findings show complex webs of presentation strategies, but in particular two changes occur during the period. First, the patient is centred throughout but the framing changes from productivity and waiting lists to quality and dialogue. Second, in the first years, the regions present themselves as actively highlighting financial and quality concerns, which changes to a passive and indirect form of presentation steered by indicators and patient legislation enforced by central government. This enhances passivity and distance in healthcare regional non-financial reporting where the regions seek to conform to such demands. Simultaneously, however, the authors find a tendency to highlight very different local initiatives, which shows an attempt to go beyond a pure automatic mode of reporting found in earlier studies.Originality/value Responding to the literature on both healthcare and financial reporting, this study identifies novel links between micro-level texts and macro-level social practices, enabling insights into the potentially intertwined impacts of public-sector reporting. The authors offer insights into the complexity of the construction of non-financial reporting in the public sector, which has a wider impact and different intentions than private-sector reporting.
Employee development and employee engagement: a review and integrated model
Authors: Kwon Kibum , Jeong Shinhee , Park Jiwon , Yoon Seung Won 
Published: January 2024

PurposeIn response to the lack of connection between employee development and employee engagement, this study explores the existing empirical findings regarding these two concepts. Based on the conservation of resources theory, the authors propose a novel theoretical framework that can better leverage the identified antecedents and relationships for future research.Design/methodology/approachAn integrative literature review of 64 empirical studies published in peer-reviewed journals was conducted.FindingsThree different levels of antecedents, including the work environment, social exchange and individual characteristics, are identified. Employee development and employee engagement exhibit reciprocal relationships. Considering the role of job performance as a catalyst, the authors propose an upward gain spiral model to advance both research and practice.Originality/valueThis integrative literature review aims to facilitate discussions based on three distinct sub-dimensions: physical, emotional and cognitive energies, relevant to both employee development and employee engagement. Through this distinction, a more comprehensive understanding of the connection between employee development and employee engagement can be cultivated.
Challenges to adopt digital construction technologies in the Jordanian construction industry
Authors: Alwashah Zaid , Sweis Ghaleb J. , Abu Hajar Husam , Abu-Khader Waleed , Sweis Rateb J. 
Published: January 2024

Purpose
This study aims to examine the challenges facing the construction industry practitioners toward adopting digital construction technologies in the Jordanian construction industry.

Design/methodology/approach
Quantitative methods were used by reviewing the related literature to include 16 challenges that face the Jordanian construction industry in adopting digital construction. A questionnaire was used to achieve the desired study objectives for 373 respondents from various institutions and companies. The questionnaire was analyzed with SPSS using statistical tests such as mean score, Kruskal–Wallis H test and factor analysis.

Findings
After collecting the quantitative data, the study showed that the most challenges facing construction industry practitioners toward adopting digital construction techniques are lack of qualified workers, high requirement for computing equipment’s, high initial cost of bringing these technologies to the market and construction firms low investment in research and development. These challenges faced by respondents were divided into three main factors, namely, construction’s nature, financial constraints and poor management support.

Originality/value
This study provides information and statistics on the challenges that face individuals or companies toward adopting digital construction techniques in Jordan. It proposes recommendations and proper practical implantation strategies to overcome the challenges.
Investigating ICT adoption and public value of e-recruitment in the public sector: the role of social media use
Authors: AbdulKareem Abdulrazaq Kayode , Oladimeji Kazeem Adebayo , Ishola Abdulrasaq Ajadi , Bello Muhammed Lawan , Umar Abubakar Yaru , Adejumo Abdulhakeem 
Published: January 2024

PurposeThis study examines the adoption of information and communication technologies (ICT) for e-recruitment and its impacts on public value outcomes.Design/methodology/approachA survey was conducted with 213 public sector employees in the federal civil service using a questionnaire to test a conceptual model integrating the Technology Acceptance Model, Media Richness Theory and Public Value Theory using PLS-SEM analysis.FindingsResults validate significant positive relationships between ICT adoption, social media use for e-recruitment and public value creation. Internet self-efficacy positively moderates public value outcomes.Research limitations/implicationsWhile this study makes valuable contributions, avenues remain to further expand generalizability, strengthen validity and incorporate additional institutional factors in the framework.Practical implicationsThe study provides insights to guide policies and interventions aimed at improving ICT adoption success and public value gains from e-government investments in developing countries.Originality/valueThe research makes key contributions by operationalizing and empirically assessing the public value impacts of e-government innovations and examining adoption issues in an understudied developing country context.
Shipping containers and speed boats: exploring the contexts and relational spaces professionals navigate to safeguard young people from criminal exploitation
Authors: Langhoff Kristine , Lefevre Michelle , Larkin Rachel 
Published: January 2024

Purpose
This paper aims to present a mixed methods study of child criminal exploitation (CCE), particularly in the form of “county lines”, in three local authorities in southeast England. The data is analysed using a framework constructed from two relevant contextual and relational theories to understand experiences of CCE and the safeguarding responses undertaken to protect young people from harm.

Design/methodology/approach
Data were drawn from a survey (n = 118); interviews (n = 5) and focus groups (n = 15) with professionals; interviews with parents (n = 4); and from secondary analysis of eight interviews with young people affected by criminal exploitation. The analytic framework was applied to the data to answer two research questions: what is the role and significance of young people’s interactions with peers, parents and professionals in their CCE trajectories; and how do professionals understand and address risks within contexts in which young people are exposed to CCE? The mixed methods data collected by the authors were coded and analysed using this framework.

Findings
Although professionals were aware of contexts and relational power dynamics, the situated and temporal nature of CCE remained overlooked within safeguarding systems. Professionals required more space, time and support to fully and flexibly engage with young people and their families to increase safety.

Originality/value
There is limited research available that critically examines safeguarding responses to CCE in diverse geographic and cultural contexts. This paper contributes a critical account of how professionals might create connections and opportunities for change with young people, identifying structural constraints within practice systems alongside emerging examples of effective practice.
Avoiding food waste from restaurant tickets: a big data management tool
Authors: Gómez-Talal Ismael , González-Serrano Lydia , Rojo-Álvarez José Luis , Talón-Ballestero Pilar 
Published: January 2024

Purpose
This study aims to address the global food waste problem in restaurants by analyzing customer sales information provided by restaurant tickets to gain valuable insights into directing sales of perishable products and optimizing product purchases according to customer demand.

Design/methodology/approach
A system based on unsupervised machine learning (ML) data models was created to provide a simple and interpretable management tool. This system performs analysis based on two elements: first, it consolidates and visualizes mutual and nontrivial relationships between information features extracted from tickets using multicomponent analysis, bootstrap resampling and ML domain description. Second, it presents statistically relevant relationships in color-coded tables that provide food waste-related recommendations to restaurant managers.

Findings
The study identified relationships between products and customer sales in specific months. Other ticket elements have been related, such as products with days, hours or functional areas and products with products (cross-selling). Big data (BD) technology helped analyze restaurant tickets and obtain information on product sales behavior.

Research limitations/implications
This study addresses food waste in restaurants using BD and unsupervised ML models. Despite limitations in ticket information and lack of product detail, it opens up research opportunities in relationship analysis, cross-selling, productivity and deep learning applications.

Originality/value
The value and originality of this work lie in the application of BD and unsupervised ML technologies to analyze restaurant tickets and obtain information on product sales behavior. Better sales projection can adjust product purchases to customer demand, reducing food waste and optimizing profits.
Measuring environmental efficiency in transportation sector based on a meta-frontier SBM approach: focusing on the Yangtze River Economic Belt (YEB) and Beijing–Tianjin–Hebei (JingJinJi)
Authors: Na Joonho , Wang Qia , Lim Chaehwan 
Published: January 2024

PurposeThe purpose of this study is to analyze the environmental efficiency level and trend of the transportation sector in the upper–mid–downstream of the Yangtze River Economic Belt and the JingJinJi region in China and assess the effectiveness of policies for protecting the low-carbon environment.Design/methodology/approachThis study uses the meta-frontier slack-based measure (SBM) approach to evaluate environmental efficiency, which targets and classifies specific regions into regional groups. First, this study employs the SBM with the undesirable outputs to construct the environmental efficiency measurement models of the four regions under the meta-frontier and group frontiers, respectively. Then, this study uses the technology gap ratio to evaluate the gap between the group frontier and the meta-frontier.FindingsThe analysis reveals several key findings: (1) the JingJinJi region and the downstream of the YEB had achieved the overall optimal production technology in transportation than the other two regions; (2) significant technology gaps in environmental efficiency were observed among these four regions in China; and (3) the downstream region of the YEB exhibited the lowest levels of energy consumption and excessive CO2 emissions.Originality/valueTo evaluate the differences in environmental efficiency resulting from regions and technological gaps in transportation, this study employs the meta-frontier model, which overcomes the limitation of traditional environmental efficiency methods. Furthermore, in the practical, the study provides the advantage of observing the disparities in transportation efficiency performed by the Yangtze River Economic Belt and the Beijing–Tianjin–Hebei regions.
Yacht crews’ perceptions of ethical climate, safety climate, psychological capital and psychological well-being in Türkiye
Authors: Yorulmaz Murat , Sevinc Basol Figen 
Published: January 2024

PurposeThis study aims to investigate the moderating role of psychological capital (PC) and the mediating role of safety climate (SC) in the relationship between the perception of psychological well-being (PWB) and ethical climate perception (ECP) of yacht crews in commercial yachts.Design/methodology/approachThis study follows a quantitative approach. Data were obtained from a total of 339 yacht crews in Türkiye. The data were analyzed using SPSS 22 and AMOS 22 statistics package software.FindingsThis study uncovers the role of SC and PC in the causal relationship between the PWB and ECP of yacht crews who are, as tourism and maritime industry employees, expected to exhibit positive organizational attitudes and behaviors. The PWB of yacht crews in the work environment is affected by their SC and PC levels.Research limitations/implicationsAlthough the holistic model of this study is a strong one, there are some limitations. The sample includes only Turkish yacht crews in yacht organizations in Türkiye. Yacht crews work periodically under harsh conditions. We acquired the research data from the yacht crews who had experienced the challenging environment; hence, the findings are specific to the crews. Ethical perceptions and standards may differ across cultures; for this reason, future research on employees in different organizations may conclude with different results. The significance of this research lies in the fact that it tests a comprehensive model.Practical implicationsThis study can guide managers in finding ways to affect the PWB of crews. Ethical and safety climate should be taken into account by yacht organizations to improve the perceptions of yacht crews. The findings show that ECP and SC have a positive effect on the PWB of yacht crews. From this perspective, this study suggests that yacht organizations should involve their crews in their ethical decisions to foster an ECP. Yacht businesses should act consistently in all areas and adopt clear safety and ethical rules and procedures for yacht crews to follow to create a perception of ethical and safety climate.Social implicationsThis study contends that yacht crews, who face lengthy shifts and professional duties, are a component of the tourism and maritime industries. The findings indicated the necessity for more study on different perspectives related to the factors that impact PWB in the light of the employees. There are relatively scarce data on yacht crews and the relationship between their PWB, SC, ECP and personality constructs such as PC. This research shows that the PWB of yacht crews in stressful and demanding working environments depends on positive ECP and high PC through SC.Originality/valueThis study is the first to assess the role of SC and PC in the relationship between the ECP and PWB of yacht crews. It further aims to fill the research gaps and build on the tourism and maritime literature on yacht crews and PWB, and climate within the tourism and maritime context.
Ideas that resonate: how ideology drives consumers’ firm-supportive market shaping
Authors: Wiebe Jeffrey 
Published: January 2024

Purpose
The purpose of this study is to understand how and why consumers engage in market-shaping activities on behalf of firms.

Design/methodology/approach
This study uses a combination of archival, netnographic and interview methods to examine how consumers responded to the entry of Tesla into the U.S. automotive market.

Findings
Consumers are driven to engage in supportive institutional work by the culturally resonant ideologies embodied in Tesla’s strategic orientation. This work takes both discursive and practical forms and sees consumers adopting responsibilities typically associated with other actors, including activists and sales professionals.

Originality/value
In developing an account of an understudied phenomenon – consumers’ firm-supportive market shaping – this research extends theorization around institutional work and cultural branding.
Trophic regulation of soil microbial biomass under nitrogen enrichment: A global meta‐analysis
Authors: Xing Wen , Chen Xinli , Thakur Madhav P. , Kardol Paul , Lu Xiaoming , Bai Yongfei 
Published: January 2024

Abstract

Eutrophication, including nitrogen (N) enrichment, can affect soil microbial communities through changes in trophic interactions. However, a knowledge gap still exists about how plant resources (‘bottom‐up effects’) and microbial predators (‘top‐down effects’) regulate the impacts of N enrichment on microbial biomass at the global scale.

To address this knowledge gap, we conducted a global meta‐analysis using 2885 paired observations from 217 publications to evaluate the regulatory effects of plant biomass and soil nematodes on soil microbial biomass under N enrichment across terrestrial ecosystems.

We found that the effects of N enrichment on soil microbial biomass varied strongly across ecosystems. N enrichment decreased the soil microbial biomass of natural grasslands and forests due to soil acidification and the subsequent losses of predatory and microbivorous nematodes stimulating microbial growth. By contrast, N enrichment increased the microbial biomass of managed croplands mainly via increasing plant biomass production. Across diverse ecosystems, the short‐term N enrichment (experimental duration ≤5 years) could reduce microbial biomass via decreasing nematode abundance, whereas the long‐term N enrichment (experimental duration >5 years) mainly promoted microbial biomass via increasing plant biomass.

These findings highlight the critical roles of microbial predators and plant input in shaping microbial responses to N enrichment, which are highly dependent on ecosystem type and the period of N enrichment. Earth system models that predict soil microbial biomass and their linkages to soil functioning should consider the variations in plant biomass and soil nematodes under future scenarios of N deposition.

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