bluuebunny/crossref_metadata_2025_split huggingface dataset:
Fluocinolone acetonide implant scleral fixation for cystoid macular edema in eyes with iris–lens diaphragm disruption
Authors: Basto Rita Costa , Francisco Catarina , Silva Alexandre Reis , Viana Ana Rita , Barbosa Renato Correia , Teixeira Sofia , Ferreira Catarina Cunha , Madeira Carolina , Carvalho Rui , Teixeira Carla , Tenedório Paula 
Published: February 2024

Abstract
This is a two-center, case series of three patients with postoperative refractory cystoid macular edema (CME) and disruption of the iris–lens diaphragm, submitted to scleral fixation of fluocinolone acetonide implant. All patients achieved successful CME reduction with visual acuity improvement. The surgical procedure was uneventful in all cases; however, one patient developed hypotony with leakage from the scleral tunnel, which was successfully resolved with reinforcement of the suture and injection of viscoelastics in the anterior chamber. No case of implant migration was observed and patients did not report any visual field disturbances. Our results emphasize this surgical technique as an effective and safe procedure for patients with persistent CME and disruption of the iris–lens diaphragm.
Fundoscopic changes in preeclampsia and eclampsia and their association with fetal outcome
Authors: Nataraju Nikitha , Apoorva N. , Chandana K. M. , Rachana B. 
Published: February 2024

Abstract

Introduction:
Hypertensive disorder is a major cause of maternal and perinatal mortality and morbidity, with preeclampsia and eclampsia being the most common. Preeclampsia is characterized by endothelial dysfunction and vasospasm of vessels, which can be observed by an ocular fundus examination. The fundus usually develops changes such as hypertensive retinopathy, papilledema, exudative retinal detachment, and vitreous and preretinal hemorrhages. Retinopathy is associated with placental insufficiency and intrauterine growth retardation. Therefore, this study has been undertaken to assess the prevalence of retinal changes in preeclampsia and their association with fetal parameters.

Objective:
To study the fundus changes in preeclampsia. To study the relationship between fundus changes and fetal outcome with respect to various parameters like birth weight, APGAR score, stillbirth, and perinatal death. To study the relationship between fundus changes with respect to proteinuria and serum uric acid.

Study Design:
Observational study.

Methodology:
One hundred patients presenting to the department of obstetrics and gynecology diagnosed with preeclampsia at a tertiary care center were included in the study. The patient recruited underwent an ocular examination using Snellen’s chart, a pupillary examination, a slit lamp examination, and a dilated fundus examination. The retinopathy was graded according to Keith and Wagner’s classification. The fetal parameters considered were birth weight, APGAR score, stillbirth, and neonatal death.

Results:
Patients ages ranged from 25 to 30 years old, with an average of 23.28 ± 3.37. Average systolic and diastolic blood pressures were 156.9 ± 17.961 and 104.88 ± 13.58, respectively. All patients had normal anterior segments. Visual acuity was6/6 in most of the patients. Fundus changes were noted in 48% of patients. Based on retinopathy classification, we found 66.7% patients with Grade 1 and 27.1% patients with Grade 2 hypertensive retinopathy. Only 6.3% of patients presented with Grade 3 hypertensive retinopathy. There was a significant association between retinopathy and proteinuria (P = 0.003), serum uric acid (P = 0.002), and the fetal birth weight (P = 0.001).

Conclusion:
Our findings suggest that progressive fundal changes in preeclampsia indicate worsening of the pathophysiological status of pregnancy-induced hypertension (PIH) and help in management. The degree of hypertensive retinopathy in women with preeclampsia is a valid and reliable prognostic factor that serves as an indirect marker of the severity of PIH and fetal outcome. Fundus examination is a simple, noninvasive, and cost-effective procedure that could be the initial finding in an asymptomatic patient who may require immediate management, which may help in saving the lives of both the mother and the baby. Fundus evaluation is essential for all patients with PIH.
Drusen classification and quantification in pseudophakic postmortem eyes implanted with or without blue-light filtering intraocular lenses
Authors: Nassrallah Emmanuel Issa Bassam , Mastromonaco Christina , Marcotte Emily , Youhnovska Emma , Abdouh Mohamed , Burnier Miguel N. 
Published: February 2024

Abstract

Purpose:
To investigate the effect of blue-light filtering intraocular lenses on drusen formation in postmortem eyes via histopathological analysis.

Materials and Methods:
One hundred and ninety-three postmortem pseudophakic eyes (100 with a clear intraocular lenses [cIOL] and 93 with a yellow, yellow intraocular lenses [yIOL]) were obtained from the Lions Gift of Sight eye bank. Sex, age-at-surgery, age-at-death, surgery-to-death time, and clinical history were collected. Eyes were sectioned on their coronal and sagittal axes, and formalin-fixed paraffin-embedded macular cross sections were obtained. Sections were stained with hematoxylin and eosin and scanned with the Zeiss Axio Scan. Z1 scanner. Drusen were classified by type, size or subtype, and quantity.

Results:
Large, soft drusen were present in 49% (n = 95) of eyes, 9% (n = 17) had cuticular drusen, 16% (n = 30) had hard drusen, and 26% (n = 51) had no drusen. There were significantly more cIOL eyes with large, soft drusen (P < 0.001). There were significantly more yIOL eyes with no drusen (P < 0.0001). No significant differences in the presence of hard or cuticular drusen were found. yIOL eyes had significantly higher mean age-at-surgery (P < 0.001) and mean age-at-death (P < 0.05), while cIOL eyes had a significantly higher mean surgery-to-death time (P < 0.05). Finally, significantly more yIOL eyes had a history of smoking (P < 0.01) and hypertension (P < 0.05), while significantly more cIOL eyes had a history of glaucoma (P < 0.05).

Conclusions:
Large, soft drusen were significantly less prevalent in yIOL eyes than in cIOL eyes and significantly more yIOL eyes had no drusen. These findings suggest that yIOLs may prevent the incidence and development of age-related macular degeneration after cataract surgery.
Performance analysis of multiview video compression based on MIV and VVC multilayer
Authors: Lee Jinho , Bang Gun , Kang Jungwon , Teratani Mehrdad , Lafruit Gauthier , Choi Haechul 
Published: February 2024

AbstractTo represent immersive media providing six degree‐of‐freedom experience, moving picture experts group (MPEG) immersive video (MIV) was developed to compress multiview videos. Meanwhile, the state‐of‐the‐art versatile video coding (VVC) also supports multilayer (ML) functionality, enabling the coding of multiview videos. In this study, we designed experimental conditions to assess the performance of these two state‐of‐the‐art standards in terms of objective and subjective quality. We observe that their performances are highly dependent on the conditions of the input source, such as the camera arrangement and the ratio of input views to all views. VVC‐ML is efficient when the input source is captured by a planar camera arrangement and many input views are used. Conversely, MIV outperforms VVC‐ML when the camera arrangement is non‐planar and the ratio of input views to all views is low. In terms of the subjective quality of the synthesized view, VVC‐ML causes severe rendering artifacts such as holes when occluded regions exist among the input views, whereas MIV reconstructs the occluded regions correctly but induces rendering artifacts with rectangular shapes at low bitrates.
Thyroid masses in Sierra Leone: a one-year retrospective clinico- pathological study
Authors: Kabba M. S. , Onyishi N. T. , Kalawa A. , Adeyinka R. K. , Duduyemi B. M. 
Published: February 2024

INTRODUCTION: Thyroid disorders are the second most common endocrine diseases in humans. There has been no study of thyroid masses in our setting in spite of recurrent presentations. We undertook a retrospective study of incident thyroidectomy cases in our anatomic pathology laboratory over one year to establish the frequency and clinico-pathologic features of thyroid masses.
METHODS: All thyroid specimens submitted to the anatomic pathology laboratory of the University of Sierra Leone Teaching Hospital Connaught from January 1, 2021 to December 31, 2021, were included in the study. Data was extracted from archived request forms, pathology reports, and patient’s case notes retrieved from the records department. The data obtained was analyzed with SPSS software.
RESULTS: Twenty-seven thyroidectomy specimens (4.5% of all surgical pathology cases) were seen over a one-year period. Ninety-two percent were from women, while 7.4% were from men. The age range of patients was 17 to 65 years; the median age (IQR) was 40 (35-48) years. Duration of mass before presentation ranged from 3 months to 50 years. About 75% of the resected thyroid masses weighed 5 to 21 times more than a normal thyroid gland. Multinodular goiter was the most common histology (70.4%). Twenty-two percent of the resected masses were malignant.
CONCLUSION: Thyroid masses constitute about 4.5% of all surgical specimens in our laboratory. Most thyroid masses are borne for years with no serious consequences. Some of the resected masses were up to 20 times the size of a normal gland. The frequency of malignant diagnoses in thyroid masses was 22.5%.
Biochemical and Molecular Identification of a <i>Native Bacillus thuringiensis gv. cytolyticus</i> Isolate with Insecticidal Effect Against the Pod Borer Larvae (<i>Helicoverpa armigera</i>)
Authors: Bouslama Thameur , Laarif Asma , Chattaoui Mayssa , Vial Ludovic , Lavire Celine , Dore Jeanne , Rhouma Ali 
Published: February 2024

The aim of this study is to isolate and identify autochthonous bacterial strains with insecticidal effect against the larvae of the tomato moth Helicoverpa armigera. Dead and diseased larvae were collected from chili plots in the region of Gotraniya from the governorate of Kairouan, Tunisia. These larvae were used to isolate eight bacterial strains named Hr1 to Hr8. The bacterial isolates were characterized by macroscopic and microscopic observations and 16S rRNA sequencing. Hr1, Hr2, Hr4, Hr5, Hr6, and Hr8 were identified as Bacillus spp., Hr3 as Staphylococcussp., and Hr7 as Enterobacter sp. Their insecticidal activity was evaluated against third-instar larvae of H. armigera. A Hr1 bacterial isolate showed an insecticidal effect against H. armigera larvae, causing 60% larval mortality four days post-treatment at a dose of 1.8 × 109 CFU/ml. Based on further characterization studies, Hr1 was identified as Bacillus thuringiensis gv. cytolyticus following Biolog biochemical tests and multi-locus sequence analyses studies based on sequencing of seven housekeeping genes.
Factors Affecting Cases of Dengue Hemorrhagic Fever in Riau Province
Authors: Fitriani Selvi , Sirait Haposan , Nurnisaa  
Published: February 2024

One infectious disease that has a high morbidity and mortality rate is Dengue Hemorrhagic Fever. Dengue Hemorrhagic Fever (DHF) is a disease caused by the dengue virus transmitted through the bite of the Aedes aegypti mosquito. In general, the habitat of Aedes mosquitoes is in areas with tropical climates, high rainfall, and hot and humid temperatures. The number of patients and the area of distribution are increasing along with increasing mobility and population density. Improper sanitation can also be a cause of DHF. In Riau province, dengue cases in 2022 continue to increase compared to 2021, with the most cases in Pekanbaru City. This study was conducted to see the factors that influence dengue cases in Riau Province. Using multiple linear regression can measure what factors affect the number of dengue cases. From the results, it was found that population density and sanitation had a significant effect on dengue cases in Riau Province. And judging from the coefficient of determination, it can be interpreted that the variables of population density (X1) and sanitation (X2) simultaneously affect the variable of dengue cases (Y) by 77.8%. While the remaining 22.2% was influenced by other variables that were not studied in this study
Texture analysis of chest X-ray images for the diagnosis of COVID-19 pneumonia
Authors: Leszczyński Waldemar , Kazimierczak Wojciech , Lemanowicz Adam , Serafin Zbigniew 
Published: February 2024

PurposeMedical imaging is one of the main methods of diagnosing COVID-19, along with real-time reverse trans­cription-polymerase chain reaction (RT-PCR) tests. The purpose of the study was to analyse the texture parameters of chest X-rays (CXR) of patients suspected of having COVID-19.Material and methodsTexture parameters of the CXRs of 70 patients with symptoms typical of COVID-19 infection were analysed using LIFEx software. The regions of interest (ROIs) included each lung separately, for which 57 para­meters were tested. The control group consisted of 30 healthy, age-matched patients with no pathological findings in CXRs.ResultsAccording to the ROC analysis, 13 of the tested parameters differentiate the radiological image of lungs with COVID-19 features from the image of healthy lungs: GLRLM_LRHGE (AUC 0.91); DISCRETIZED_Q3 (AUC 0.90); GLZLM_HGZE (AUC 0.90); GLRLM_HGRE (AUC 0.89); DISCRETIZED_mean (AUC 0.89); DISCRETIZED_Q2 (AUC 0.61); GLRLM_SRHGE (AUC 0.87); GLZLM_LZHGE (AUC 0.87); GLZLM_SZHGE (AUC 0.84); DISCRETIZED_Q1 (AUC 0.81); NGLDM_Coarseness (AUC 0.70); DISCRETIZED_std (AUC 0.64); CONVENTIONAL_Q2 (AUC 0.61).ConclusionsSelected texture parameters of radiological CXRs make it possible to distinguish COVID-19 features from healthy ones.
Kesiapan Kota Denpasar dalam Mewujudkan Kota Sehat pada Era Kenormalan Baru
Authors: Saputro Dimas Indo 
Published: February 2024

Tujuan: Penelitian ini bertujuan untuk mengetahui seberapa besar kematangan atau kesiapan Kota Denpasar dalam mewujudkan Kota Sehat pada masa kenormalan baru.
Metode penelitian: Penelitian ini menggunakan pendekatan deduktif kuantitatif dengan melakukan observasi dan kajian literature terkait penerapan Kota Sehat dan Era Kenormalan Baru di masa pandemi COVID-19.
Hasil dan pembahasan: Hasil penelitian menemukan Kota Denpasar berada pada tingkat agak siap dalam mewujudkan Kota Sehat pada Era Kenormalan Baru.
Implikasi: Penelitian ini menjadi bahan pertimbangan dan perbaikan dalam mewujudkan Kota Sehat di era kenormalan baru.
Dampak Pandemi Covid-19 terhadap Ketenagakerjaan di Provinsi Bali
Authors: Ayupijaya Manila 
Published: February 2024

Tujuan: Penelitian ini bertujuan untuk memberikan gambaran bahwa pandemi Covid-19 berdampak sangat parah terhadap perekonomian dan hal lainnya di Bali sebagai daerah yang mengandalkan sektor pariwisata.
Metode penelitian: Metode yang digunakan dalam penelitian ini adalah metode deskriptif-kualitatif. Teknik pengumpulan data dilakukan melalui observasi, wawancara, dan dokumentasi.
Hasil dan pembahasan: Hasil penelitian menunjukkan bahwa di samping dampak negatif yang ditimbulkan akibat pandemi Covid-19, ada dampak positif sektor ketenagakerjaan dalam upaya percepatan digitalisasi transformasi pekerjaan yang menuntut masyarakat cepat beradaptasi dengan segala perubahan yang membentuk tatanan kehidupan dan dunia kerja baru seiring tuntutan revolusi industri 4.0.
Implikasi: Diperlukan upaya yang komprehensif serta kebijakan yang cepat dan tepat guna menghadapi dampak pandemi Covid-19 di sektor ketenagakerjaan untuk melindungi dan memulihkan kesejahteraan pekerja baik saat ini maupun setelah pandemi.
Optimalisasi Peran Linmas menuju Bali Trepti pada Masa Pandemi Covid-19
Authors: Suciati Desak Ayu Putu , Language I Ketut Pongres 
Published: February 2024

Tujuan: Tujuan penelitian ini adalah untuk mengetahui bagaimanakah strategi yang dilakukan Satpol PP Provinsi Bali dalam upaya penagggulangan lonjakan masyarakat terkonfirmasi Covid-19 di Provinsi Bali. Yang kedua adalah untuk mengetahui program dan kegiatan yang dilakukan Satpol PP Provinsi Bali dalam upaya penagggulangan lonjakan kasus Covid-19 di Provinsi Bali.
Metode penelitian: Penelitian ini dilakukan dengan metode penelitian deskriptif-kualitatif, yang lebih banyak menggunakan dan mengumpulkan informasi dengan cara mendalami setiap fenomena sosial yang terjadi.
Hasil dan pembahasan: Strategi yang dilakukan Satpol PP Provinsi Bali dalam upaya penagggulangan lonjakan masyarakat terkonfirmasi Covid-19 di Provinsi Bali melalui pendekatan Whole of Government (WoG). Dilakukan juga sinergitas/kolaborasi kewenangan dengan program/kegiatan yang melibatkan sejumlah kelembagaan terkait serta memanfaatkan kewenangan dan kekuasaan pemerintah daerah untuk mampu menghegemoni masyarakat ditingkat bawah sehingga muncul kesadaran/keterpanggilan dari setiap individu untuk mematuhi protocol kesehatan sehingga mampu mewujudkan Bali Trepti
Implikasi: Program dan kegiatan yang dilakukan Satpol PP Provinsi Bali dalam upaya penagggulangan lonjakan kasus Covid-19, yaitu dengan melaksanakan Program Bali Trepti dan beberapa kegiatan antara lain Operasi gabungan penertiban penduduk nonpermanen dengan melibatkan anggota Linmas di beberapa Kabupaten/Kota se Bali, Patroli dan Penegakan Pergub Bali No. 10 Tahun 2021 tentang Penerapan Disiplin dan Penegakan Hukum Protokol Kesehatan dan Penerapan SE Gubernur Bali No. 9 Tahun 2021 tentang Penerapan PPKM Darurat di Provinsi Bali.
Strategy Development for Puri Peliatan Heritage Tourism
Authors: Sucantra Made Bayu , Budiasa I Made , Nurjaya I Wayan 
Published: February 2024

Purpose: This study aims to identify the strategy and program of Puri Peliatan (Peliatan Palace) as a heritage attraction in Peliatan Tourism Village, Ubud, Bali, Indonesia.
Research methods: The data collection technique in this research is observation. Quotation is done from existing library materials, and other sources. Data analysis techniques used are descriptive-qualitative.
Results and discussion: The main strategy planning of Puri Peliatan Ubud as an attraction of heritage tourism is by designing various programs. Puri Peliatan has a lot of tangible and intangible potential that can be developed as a tourist attraction, especially in heritage tourism.
Implication: This study has a limited scope in identifying existing conditions of tourism in Puri Peliatan and Puri Peliatan planning as a heritage attraction so that a further study is needed.
Peran Masyarakat Adat Bali dalam Persetujuan Kesesuaian Kegiatan Pemanfaatan Ruang
Authors: Ogiana Gede , Dewi Putu Sri Ronita 
Published: February 2024

Tujuan: Artikel ini adalah untuk merumuskan alternatif model kebijakan terkait peran masyarakat adat Bali dalam persetujuan kesesuaian kegiatan pemanfaatan ruang demi mewujudkan penyelenggaraan penataan ruang yang melestarikan lingkungan alam, adat istiadat, tradisi, seni dan budaya, serta kearifan lokal sebagai jati diri masyarakat Bali.
Metode penelitian: Penelitian ini menggunakan metode deskriptif kualitatif melalui studi kepustakaan/literatur dengan menelaah berbagai data sekunder seperti kajian, jurnal, materi teknis, serta peraturan perundang-undangan terkait.
Hasil dan pembahasan: Kesesuaian Kegiatan Pemanfaatan Ruang yang disingkat KKPR berfungsi menggantikan berbagai izin pemanfaatan ruang. Penerbitan Persetujuan KKPR dilakukan dengan melibatkan pertimbangan dari Forum Penataan Ruang. Masyarakat adat Bali yang memahami kearifan lokal Bali dapat berperan sebagai anggota di Forum Penataan Ruang dengan menyampaian masukkan mengenai pemanfaatan ruang dengan memperhatikan kearifan lokal.
Implikasi: Peran masyarakat adat Bali dalam penerbitan Kesesuaian Kegiatan Pemanfaatan Ruang diharapkan dapat menjaga nilai-nilai adat dan budaya Bali dan melestarikan identitas ruang dan lingkungan alam Bali.
Prototipe Perpustakaan Virtual Museum & Galeri Sby*Ani Dengan Design Innovation Methode
Authors: Amalina Nabila , Susetyarto Martinus Bambang 
Published: February 2024

Virtual architecture has unlimited space. The space is one of the answers to the
fulfillment of space needs on limited land in the real world. The development of
the library at the SBY*Ani Museum and Gallery is actually thinking about using
virtual architecture to meet the demands of providing an alternative space that
can functionate the library to keep books and collections, with low cost and
sustain quality layout management, and flexible visiting times for
readers/borrowers. Purpose of the research was finding a library prototype that
give a pleasant space experience and user friendly, also having an impact on the
sustainability of library management which was combaining architecture of the
virtual world and of the real world. The research used the Design Innovation
Method (Kumar V., 2013) which has seven different activity modes for design
innovation, namely: Sense Intent, Know Context, Know People, Frame Insights,
Explore Concepts, Frame Solutions, and Realize Offerings. The result of the
research was a virtual library prototype at the SBY*Ani Museum and Gallery which
is an effort to develop the architecture of the library space in the virtual world
combined with architecture in the real world. The development was carried out to
accommodate space needs, especially a pleasant space experience and user
friendly space that provide books and collections, and to design other spaces that
can be built in the virtual world, with attractive interior designs, user friendly
products, safe, comfortable, and flexible for readers/borrowers. By this research
process which was using the Design Innovation Method, at least three prototypes
were found, namely D0, D1, and D2. All three have been tested and are being
evaluated to establish the findings of the research. This research has limitations in
terms of funding and research work time, in which researchers must combine the
research work schedule with the work schedule for the SBY*Ani Museum and
Gallery construction project, as well as the situation and conditions for the
application of restrictions on community activities due to the Covid-19 pandemic.
The research value was unique in terms of the research methods and findings,
originality, and useful impact that can be felt by the community and owner of the
Museum and Gallery SBY*Ani
Ibrutinib (Imbruvica)
Authors: CADTH  
Published: February 2024

CADTH recommends that Imbruvica, with or without rituximab, should be reimbursed by public drug plans for the treatment of adult patients with previously treated relapsed or refractory Waldenström’s macroglobulinemia (WM) if certain conditions are met.
Imbruvica should only be covered to treat adult patients who have WM and have received at least 1 prior line of therapy, have good performance status, and who meet at least 1 criterion for treating WM according to the latest International Workshop on WM criteria.
Imbruvica should not be reimbursed for patients who have received prior treatment with a Bruton tyrosine kinase inhibitor and whose disease responded poorly or for patients with disease transformation. Imbruvica should only be prescribed by hematologists or oncologists with experience in treating patients with WM, and the cost of Imbruvica should be negotiated to provide cost savings for drug programs relative to zanubrutinib.