bluuebunny/crossref_metadata_2025_split huggingface dataset:
Recommendations for reproducibility of cerebrospinal fluid extracellular vesicle studies
Authors: Sandau Ursula S. , Magaña Setty M. , Costa Júlia , Nolan John P. , Ikezu Tsuneya , Vella Laura J. , Jackson Hannah K. , Moreira Lissette Retana , Palacio Paola Loreto , Hill Andrew F. , Quinn Joseph F. , Van Keuren‐Jensen Kendall R. , McFarland Trevor J. , Palade Joanna , Sribnick Eric A. , Su Huaqi , Vekrellis Kostas , Coyle Beth , Yang You , Falcón‐Perez Juan M. , Nieuwland Rienk , Saugstad Julie A. ,   International Society for Extracellular Vesicles Cerebrospinal Fluid Task Force
Published: December 2023

AbstractCerebrospinal fluid (CSF) is a clear, transparent fluid derived from blood plasma that protects the brain and spinal cord against mechanical shock, provides buoyancy, clears metabolic waste and transports extracellular components to remote sites in the brain. Given its contact with the brain and the spinal cord, CSF is the most informative biofluid for studies of the central nervous system (CNS). In addition to other components, CSF contains extracellular vesicles (EVs) that carry bioactive cargoes (e.g., lipids, nucleic acids, proteins), and that can have biological functions within and beyond the CNS. Thus, CSF EVs likely serve as both mediators of and contributors to communication in the CNS. Accordingly, their potential as biomarkers for CNS diseases has stimulated much excitement for and attention to CSF EV research. However, studies on CSF EVs present unique challenges relative to EV studies in other biofluids, including the invasive nature of CSF collection, limited CSF volumes and the low numbers of EVs in CSF as compared to plasma. Here, the objectives of the International Society for Extracellular Vesicles CSF Task Force are to promote the reproducibility of CSF EV studies by providing current reporting and best practices, and recommendations and reporting guidelines, for CSF EV studies. To accomplish this, we created and distributed a world‐wide survey to ISEV members to assess methods considered ‘best practices’ for CSF EVs, then performed a detailed literature review for CSF EV publications that was used to curate methods and resources. Based on responses to the survey and curated information from publications, the CSF Task Force herein provides recommendations and reporting guidelines to promote the reproducibility of CSF EV studies in seven domains: (i) CSF Collection, Processing, and Storage; (ii) CSF EV Separation/Concentration; (iii) CSF EV Size and Number Measurements; (iv) CSF EV Protein Studies; (v) CSF EV RNA Studies; (vi) CSF EV Omics Studies and (vii) CSF EV Functional Studies.
The moment arms and lines of action of subscapularis after the Latarjet procedure
Authors: Fox Aaron , Ernstbrunner Lukas , Henze Janina , Page Richard S. , Ackland David C. 
Published: December 2023

AbstractThe Latarjet procedure is an established surgical treatment for recurrent glenohumeral joint instability with glenoid bone loss. Intraoperatively, the conjoint tendon and its attachement on the coracoid bone graft is routed through a split in subscapularis where the graft is fixed to and augments the anteroinferior glenoid. The objective of this in vitro study was to quantify the influence of glenohumeral joint position and conjoint tendon force on the lines of action and moment arms of subscapularis muscle sub‐regions after Latarjet surgery. Eight fresh‐frozen, entire upper extremities were mounted onto a testing apparatus, and a cable‐pulley system was used to apply physiological muscle loading to the major shoulder muscles. The lines of action and moment arms of four subregions of subscapularis (superior, mid‐superior, mid‐inferior, and inferior) were quantified radiographically with the conjoint tendon unloaded and loaded while the shoulder was in (i) 0° abduction (ii) 90° abduction (iii) 90° abduction and full external rotation (ABER), and (iv) the apprehension position, defined as ABER with 30° horizontal extension. Conjoint tendon loading after Latarjet surgery significantly increased the inferior inclination of the lines of action of the mid‐inferior and inferior subregions of subscapularis in the scapular plane in ABER and apprehension positions (p < 0.001), as well as decreased the horizontal flexion moment arm of the inferior subscapularis (p = 0.040). Increased subscapularis inferior inclination may ultimately increase inferior joint shear potential, while smaller horizontal flexion leverage may reduce joint flexion capacity. The findings have implications for Latarjet surgical planning and postoperative rehabilitation prescription.
The structural characteristics and physicochemical properties of mung bean protein hydrolysate of protamex induced by ultrasound
Authors: Bing Shu‐Jing , Liu Fen‐Fang , Li Ying‐Qiu , Sun Gui‐Jin , Wang Chen‐Ying , Liang Yan , Zhao Xiang‐Zhong , Hua Dong‐Liang , Chen Lei , Mo Hai‐Zhen 
Published: December 2023

AbstractBACKGROUNDThe limited physicochemical properties (such as low foaming and emulsifying capacity) of mung bean protein hydrolysate restrict its application in the food industry. Ultrasound treatment could change the structures of protein hydrolysate to accordingly affect its physicochemical properties. The aim of this study was to investigate the effects of ultrasound treatment on the structural and physicochemical properties of mung bean protein hydrolysate of protamex (MBHP). The structural characteristics of MBHP were evaluated using tricine sodium dodecylsulfate–polyacrylamide gel electrophoresis, laser scattering, fluorescence spectrometry, etc. Solubility, fat absorption capacity and foaming, emulsifying and thermal properties were determined to characterize the physicochemical properties of MBHP.RESULTSMBHP and ultrasonicated‐MBHPs (UT‐MBHPs) all contained five main bands of 25.8, 12.1, 5.6, 4.8 and 3.9 kDa, illustrating that ultrasound did not change the subunits of MBHP. Ultrasound treatment increased the contents of α‐helix, β‐sheet and random coil and enhanced the intrinsic fluorescence intensity of MBHP, but decreased the content of β‐turn, which demonstrated that ultrasound modified the secondary and tertiary structures of MBHP. UT‐MBHPs exhibited higher solubility, foaming capacity and emulsifying properties than MBHP, among which MBHP‐330 W had the highest solubility (97.32%), foaming capacity (200%), emulsification activity index (306.96 m2 g−1) and emulsion stability index (94.80%) at pH 9.0.CONCLUSIONUltrasound treatment enhanced the physicochemical properties of MBHP, which could broaden its application as a vital ingredient in the food industry. © 2023 Society of Chemical Industry.
Squamous Cell Carcinoma of the Nasal Vestibule: A Multi‐Centric Observational Cohort Study
Authors: Pirola Francesca , Di Santo Davide , Turri‐Zanoni Mario , Chabrillac Emilien , Fradeani Dario , Sionis Sara , Carta Filippo , Lambertoni Alessia , Malvezzi Luca , Galli Andrea , Giordano Leone , Puxeddu Roberto , Castelnuovo Paolo , Mercante Giuseppe , Spriano Giuseppe , Ferreli Fabio 
Published: December 2023

ObjectivesSquamous cell carcinoma of the nasal vestibule (NV‐SCC) is a rare but challenging entity, due to the complex anatomy of the region. Consensus on the best treatment strategy is still lacking, as well as a dedicated staging system. Our aim was to analyze oncological outcomes of surgically treated patients and to investigate possible prognostic factors.MethodsWe performed a retrospective multi‐centric observational study including six Academic Hospitals over a 10‐year period, including only patients who underwent upfront surgery for primary NV‐SCC. Patients were staged according to all currently available staging systems. The Kaplan–Meier method was used to compute overall, disease‐free, and disease‐specific survival. Logistic regression models were used to correlate between survival outcomes and clinical and pathological variables.ResultsSeventy‐one patients with a median follow‐up of 38 months were included in the study. Partial and total rhinectomy were the most commonly performed procedures, respectively, in 49.3% and 25.4% of cases. Neck dissection was performed on 31% of patients, and 45.1% of them underwent adjuvant radiotherapy. Three years overall, disease‐specific and disease‐free survival were, respectively, 86.5%, 90.3%, and 74.2%. None of the currently available staging systems were able to effectively stratify survival outcomes. Factors predicting lower overall survival on multivariate analysis were age (p = 0.021) and perineural invasion (p = 0.059), whereas disease‐free survival was negatively affected by age (p = 0.033) and lymphovascular invasion (p = 0.019).ConclusionCurrently available staging systems cannot stratify prognosis for patients who underwent surgery for NV‐SCC.Level of Evidence4 Laryngoscope, 134:2634–2645, 2024
Why Do Cochlear Implant Candidates Defer Surgery? A Retrospective Case–Control Study
Authors: Kato Masanari G. , Kaul Vivian F. , Hallak Diana , Zhang Lisa , Moberly Aaron C. , Ren Yin 
Published: December 2023

Objective(s)Despite undergoing thorough cochlear implant (CI) candidacy evaluation and counseling, some patients ultimately elect against implantation. This study sought to identify patient‐related and socioeconomic factors predicting CI deferral.MethodsA retrospective study of adult (≥18 years old) CI candidates presenting between 2007 and 2021 at a tertiary academic CI center was performed. The primary outcome was device implantation. Data collected included age, gender, hearing status, race, zip code of residence, median family income (MFI), distance traveled from the CI center, marital status, employment status, and insurance status. Multivariable binary logistic regression was performed to identify predictors of implantation.ResultsA total of 200 patients qualifying for CI were included, encompassing 77 adults deferring surgery (CI‐deferred) and 123 consecutive adults electing for surgery (CI‐pursued). Age, gender, hearing status, insurance type, employment status, distance from the implant center, and MFI were comparable between the groups (p > 0.05). Compared to CI‐pursued patients, CI‐deferred patients were more likely to be non‐Caucasian (24.7% vs. 9.8%, p = 0.015) and unmarried (55.8% vs. 38.2%, p = 0.015). On multivariable logistic regression, older age (OR 0.981, 0.964–0.998, p = 0.027), African American race (OR 0.227, 0.071–0.726, p = 0.012), and unmarried status (OR 0.505, 0.273–0.935, p = 0.030) were independent predictors of implant deferral.ConclusionThis study demonstrates that increasing age at evaluation, African American race, and unmarried status are predictors for deferring CI surgery despite being implant candidates. These patients may benefit from increased outreach in the form of counseling, education, and social support prior to undergoing CI surgery.Level of Evidence3 – retrospective study with internal control group Laryngoscope, 134:2857–2863, 2024
What kind of support can promote academic entrepreneurial intention: An analysis of the Qualitative Comparative Analysis configuration effect of multiple support
Authors: Luo Wei , Ran Qiaodan , Cheng Suiying 
Published: December 2023

AbstractThrough one‐way analysis of variance (ANOVA), it is found that monthly salary and academic entrepreneurial intention have a “U‐shaped” relationship. In qualitative comparative analysis (QCA), single‐factor necessity analysis found that self‐emotional support and family emotional support constitute the necessary conditions. Through multifactor configuration analysis, four paths are summarized as follows: “internal drive type,” “resource utilization type,” “relationship infection type,” and “opportunity capture type.” Through cross‐configuration comparative analysis, it is found that different support subjects have a substitution effect, the strong linkage relationship between self and family becomes a necessary condition, and emotional support is better than instrumental support.
An improved implementation of volumetric SBR for EM scattering of a large‐scale target coated with plasma
Authors: Cai Yufeng , Yang Wei , Gao Weizhi , He Ziyuan , Hu Haoquan , Lei Shiwen 
Published: December 2023

AbstractIn this paper, the volumetric shooting and bouncing rays method is proposed to investigate the electromagnetic (EM) scattering of the large‐scale target coated with plasma, which takes into account the EM rays propagating inside the interior of the plasma and fully captures the dominant scattering characteristics. Furthermore, an efficient graphics processing unit‐based implementation procedure with a ray management strategy is proposed to deal with the problem of the exponential increase of EM rays in plasma medium. The numerical results of a multilayer cuboid model and the RAM C‐II vehicle demonstrate the proposed method has a good computational efficiency and achieves a significant accuracy improvement compared to the traditional shooting and bouncing ray, with a root mean square error reduced from 13.29 dB to less than 4.96 dB. It indicates the proposed method has the potential to solve the EM scattering of the large‐scale target coated with plasma. Finally, some simulations of the RAM C‐II are performed at higher radar frequencies to illuminate that the plasma sheath causes complex scattering of the target of interest in terms of the flight speed, flight altitude, and radar frequency.
Design of resonant metasurface absorber using feed‐forward neural network
Authors: Abraray Abdelghafour , Baghel Amit , Maslovski Stanislav 
Published: December 2023

AbstractIn this work, an ultrathin ( mm) design of a frequency‐selective metamaterial absorber (MTA) is proposed. An absorption of 100% is achieved at the resonant frequency  GHz with a fractional bandwidth of 1.45%. The MTA unit cell geometry is parametrized and modeled in a full‐wave electromagnetic simulator. Using a data set generated by varying the absorber unit cell geometry and simulating it in SIMULIA CST Studio Suite, the feed‐forward neural network is able to learn the relationship between the physical structure and its electromagnetic response. The numerical results for the MTA performance have been confirmed by an experiment. An array of 25 MTA elements in a configuration has been fabricated and tested in an anechoic chamber. The simulated and measured results are in a good agreement.
5G millimeter‐wave MIMO DRAs with reduced mutual coupling
Authors: Dash Sounik Kiran Kumar , Cheng Qingsha S. , Khan Taimoor , Yadav Manish Varun , Wang Lei 
Published: December 2023

AbstractA novel simple decoupling technique is proposed to suppress the mutual coupling of a millimeter‐wave multiple‐input‐multiple‐output dielectric resonator antenna (DRA). The design to be decoupled consists of two microstrip‐line fed rectangular DRAs placed side‐by‐side on an RT‐Duroid substrate and operates near 26 GHz. First, the DRAs are placed at an appropriate separation distance to avoid any close coupling. Second, to reduce coupling further, a set of square ring cell loaded slot is employed on the ground plane in between the DRAs. These two arrangements together, potentially reduce the mutual coupling between the DR elements and substantially improves the in‐band isolation from 14 to 23 dB (min)/34 dB (max) between them. The design is very simple, compact, and easy to fabricate. The model is prototyped and characterized to demonstrate its feasibility for operation. This can be a suitable technique for fifth‐generation compact handheld microwave devices.
Gastrointestinal and genitourinary symptoms in facioscapulohumeral muscular dystrophy: Prevalence and impact
Authors: Cole Michael R. , Cooper Christopher S. , Hanna Eyad M. , Zimmerman M. Bridget , Kinoshita June , Mathews Katherine D. 
Published: December 2023

AbstractIntroduction/AimsAnecdotally, patients with facioscapulohumeral muscular dystrophy (FSHD) describe gastrointestinal (GI) and genitourinary (GU) symptoms. We explored the prevalence of GI and GU symptoms and their impact on quality of life (QOL) in people with FSHD compared to healthy household controls.MethodsIn this descriptive, cross‐sectional study, we emailed a survey exploring GI and GU symptoms to all FSHD Society patient contacts (n = 3507). We invited those with FSHD and unaffected household controls to respond. Non‐parametric statistics were used to compare symptom frequency and impact of symptoms between respondents with FSHD and household controls. Within the FSHD group, symptom frequency was assessed relative to measures of disease progression (need for ambulatory or respiratory support).ResultsSurveys from 701 respondents (652 with FSHD) ≥18 years old were included in analysis. Those with FSHD had symptoms affecting both GI and GU systems more frequently than controls using ordinal rating of symptom frequency. Within the FSHD group, more advanced disease was associated with increased symptom frequency. QOL was negatively impacted by the GI and GU symptoms. There was no difference between groups in use of medications to treat these symptoms.DiscussionRecognition and treatment of GI and GU symptoms in people with FSHD, particularly those with more advanced disease, could improve QOL. Additional investigation is required to confirm these findings and understand the physiology.
Quantitative muscle ultrasound in adult spinal muscular atrophy. A pilot study
Authors: Pelosi Luciana , Rodrigues Miriam , Zhong Cathy , Patel Shilpan , Roxburgh Richard 
Published: December 2023

AbstractIntroduction/AimsMuscle ultrasound has been investigated in children with spinal muscular atrophy (SMA) and proposed as a potential biomarker of disease severity. We studied the ultrasound properties in adults with SMA to see whether they also have potential as markers of disease severity in older patients.MethodsThickness and quantitative echogenicity of muscle and subcutaneous tissue were compared between eight prospectively recruited adult patients with SMA and eight age, sex and body mass index‐matched controls. Measurements were made in the dominant deltoid, biceps, triceps, forearm extensors, first dorsal interosseous, quadriceps, tibialis anterior, and gastrocnemius muscles. The muscle‐to‐subcutaneous (M:S) thickness and echogenicity ratios were also calculated. A mean value across all muscles as well as the individual values for each muscle were then calculated for each parameter in each subject and compared between the two groups. Significance was set at 0.05 after Bonferroni correction.ResultsIn the SMA patients, mean muscle thickness was significantly smaller (1.3 vs. 1.9 cm), muscle echogenicity higher (106 vs. 67 on the grayscale level), and subcutaneous thickness larger (0.9 vs. 0.3 cm) than in controls; M:S echogenicity ratio was significantly increased and M:S thickness ratio reduced in the patients. The most abnormal scores were found in the nonambulatory patients and the least abnormal in the ambulatory patients.DiscussionUltrasound can detect and quantify the severity of muscle atrophy and structure in adult SMA, suggesting a potential role as a marker of disease severity, which will require validation by larger studies.
Identifying key barriers to nonprofit organizations' adoption of technology innovations
Authors: Godefroid Marie‐E. , Plattfaut Ralf , Niehaves Björn 
Published: December 2023

AbstractDespite substantial innovations in Information and Communication Technologies (ICT) that could benefit non‐governmental organizations (NGOs), NGOs are not using ICT yet to their full potential – especially compared to the ICT use in the private sector. Such behavior appears counterintuitive as one would expect NGOs to use every available resource to further their important mission. However, reservations appear to remain even though several case studies demonstrated the value ICT can generate for NGOs. Through a series of 20 interviews with NGOs of various sizes and backgrounds, we examined the use of ICT along the NGO value chain (program design, fundraising, fund management, and program delivery). We find a distinct prioritization of ICT support along the value chain. Based on these findings, we identify six sector‐specific reasons for NGOs not to use ICT for certain activities. With these, we add to known reasons in the literature and offer important avenues for further research.
Descriptive analysis on disproportionate medication errors and associated patient characteristics in the Food and Drug Administration's Adverse Event Reporting System
Authors: Pera Victor , van Vaerenbergh Frauke , Kors Jan A. , van Mulligen Erik M. , Parry Rowan , de Wilde Marcel , Lahousse Lies , van der Lei Johan , Rijnbeek Peter R. , Verhamme Katia M. C. 
Published: December 2023

AbstractBackgroundMedication errors (MEs) are a major public health concern which can cause harm and financial burden within the healthcare system. Characterizing MEs is crucial to develop strategies to mitigate MEs in the future.ObjectivesTo characterize ME‐associated reports, and investigate signals of disproportionate reporting (SDRs) on MEs in the Food and Drug Administration's Adverse Event Reporting System (FAERS).MethodsFAERS data from 2004 to 2020 was used. ME reports were identified with the narrow Standardised Medical Dictionary for Regulatory Activities® (MedDRA®) Query (SMQ) for MEs. Drug names were converted to the Anatomical Therapeutic Chemical (ATC) classification. SDRs were investigated using the reporting odds ratio (ROR).ResultsIn total 488 470 ME reports were identified, mostly (59%) submitted by consumers and mainly (55%) associated with females. Median age at time of ME was 57 years (interquartile range: 37–70 years). Approximately 1 out of 3 reports stated a serious health outcome. The most prevalent reported drug class was “antineoplastic and immunomodulating agents” (25%). The most common ME type was “incorrect dose administered” (9%). Of the 1659 SDRs obtained, adalimumab was the most common drug associated with MEs, noting a ROR of 1.22 (95% confidence interval: 1.21–1.24).ConclusionThis study offers a first of its kind characterization of MEs as reported to FAERS. Reported MEs are frequent and may be associated with serious health outcomes. This FAERS data provides insights on ME prevention and offers possibilities for additional in‐depth analyses.