bluuebunny/crossref_metadata_2025_split huggingface dataset:
The impact of dietary fat type on lipid profiles in lean mass hyper‐responder phenotype
Authors: Takemura Yuma , Inoue Tomoko , Matsunaga Keiji , Tani Ryosuke , Fu Hai Ying , Minamino Tetsuo 
Published: February 2024

Key Clinical MessageAlthough the lean mass hyper‐responder (LMHR) phenotype is well known, its diagnosis is impeded by the influence of fat type and intake on the lipid profile. Accordingly, a detailed assessment is warranted if LMHR is suspected.AbstractA 47‐year‐old man with suspected familial hypercholesterolemia presented with elevated triglyceride and low‐density lipoprotein cholesterol levels. He had adhered to a ketogenic diet and was suspected of a lean mass hyper‐responder phenotype; however, his lipid profile did not meet the definition. His lipid profile improved through dietary management without medication.
Lipoid proteinosis: A rare genodermatosis with multisystemic manifestations—A case report
Authors: Hashmi Farah Naaz , Huma Sumera , Singireddy Harshini , Zareen Nikhat , Suvvari Tarun Kumar , Ansari Mustafa Hussain , Sultana Nudrat , Hasibuzzaman Md. Al 
Published: February 2024

Key Clinical MessageLipoid proteinosis (LP) is a rare autosomal recessive genodermatosis, which is characterized by the deposition of amorphous hyaline material in various tissues, including the mucosa, visceral organs, and skin. We report a case of a 11‐year‐old girl born to consanguineous parents presented with multisystemic manifestations of the disorder. The patient presented with progressive skin lesions evolving from blisters to papules, distinctive beaded papules along eyelid margins, hoarseness of voice, impaired speech, hair loss, and a painful jaw swelling. Clinical examination revealed waxy skin, atrophic scars, and keratotic plaques. Histopathology report revealed amorphous hyaline eosinophilic material deposition. This case report highlights the multisystemic manifestations of LP and the importance of early diagnosis and management.
Pushing the Efficiency of the Selective and Base‐Free Air‐Oxidation of HMF by Varying the Properties of Carbon‐Based Supports
Authors: Neukum Dominik , Saraçi Erisa , Krause Bärbel , Lakshmi Nilayam Ajai Raj , Sinigalia Alisa , Grunwaldt Jan‐Dierk 
Published: February 2024

AbstractThe selective oxidation of 5‐(Hydroxymethyl)furfural (HMF) to 2,5‐Furandicarboxylic acid (FDCA) is highly attractive for the production of renewable monomers as substitute for fossil‐based monomers. To achieve a sustainable synthesis, we report on advances for a base‐free approach, reducing waste from the process, using air as oxidant and heterogeneous catalysts. Various Carbon‐based supports, which can be bio‐sourced and cost‐efficient, for Pt particles were investigated as they allow for an easy reuse and at the end‐of‐life Pt can be recycled to enable a closed cycle. Commercially available supports with varying properties, which might replace the base, were studied with Pt particles of similar size and loading. Significant differences in the catalytic activity were observed, which were correlated with the O‐functionalities and graphitization degree of the supports derived from Raman spectroscopy, temperature‐programmed desorption, and X‐ray photoelectron spectroscopy. An activated carbon (Norit ROX) rich in quinone/pyrone‐type groups and a carbon black‐based catalyst with graphene‐layers pushed the efficiency with enhanced FDCA‐yields enabling the complete substitution of the homogeneous base. This allows to circumvent the base in this process which together with high selectivity, air as oxidant, a reusable catalyst, and the use of bio‐based feedstock contributes to the sustainability of the production of renewable monomers.
Studying the Structure‐Reactivity Relationship of CuO/CeO2 for Catalytic Soot Particulate Combustion: On the Monolayer Dispersion Threshold Effect
Authors: Shen Jiating , Zhang Shijing , Shen Hailing , Xu Xianglan , Fang Xiuzhong , Wang Xiang 
Published: February 2024

AbstractTo elucidate structure‐reactivity relationship and prepare improved catalysts for soot combustion, a series of CuO/CeO2 with different loadings have been fabricated by the impregnation method. With XRD and XPS extrapolation methods, it is disclosed that CuO disperses finely on the CeO2 support to form a monolayer with a capacity around 1.06 mmol 100 m−2, which equals to 2.9 wt. % CuO loading. Below this capacity, CuO is in a sub‐monolayer state. However, above this capacity, CuO micro‐crystallites are formed, and co‐exist with the monolayer CuO. By increasing CuO loading, soot combustion activity of the catalysts increases as well until it reaches the monolayer dispersion capacity. Further increasing the CuO loading to 5 % decreases the activity slightly, and then remains constant. Therefore, an apparent monolayer dispersion threshold effect is observed for soot combustion on CuO/CeO2 catalysts. It is found that the amount of surface‐active O2− sites plays critical role for the catalytic activity. To obtain the most active CuO/CeO2 catalyst, a monolayer amount of CuO should be loaded on the supports.
Preparation and sound absorption performance of low‐carbon fly ash cenosphere plates
Authors: Yi Yongli , Li Chu , Han Yu , Nie Jingkai , Fan Chao , He Qiang 
Published: February 2024

ABSTRACTA series of low‐carbon fly ash cenosphere plates was prepared using solid waste based cementitious material as binder through a simple process; meanwhile, effects of cenosphere's particle size and size distribution on microstructure and properties were investigated. In the range of 20–200 mesh, as particle size decreases, sound absorption performance decreases while strength improves. Appropriate particle grading can effectively improve the compressive strength, but it will lead to a significant decrease in sound absorption performance. Samples prepared from fly ash cenosphere with a particle size of 20–40 mesh show good sound absorption performance: when the cavity size is 0 mm, the maximum sound absorption coefficient is 0.64 and the average value is 0.36 in the range of 50–1 600 Hz; when the cavity size is 100 mm, sound absorption coefficient at 100 Hz is 0.47, the maximum sound absorption coefficient in the range of 50–1 600 Hz is 0.90, and the average value is 0.57 in the range of 100–500 Hz. The prepared low‐carbon fly ash cenosphere plates show excellent sound absorption performance at low‐frequency and are expected to have broad application prospects in low‐frequency noise reduction and absorption.
Development of Receptor for Advanced Glycation End Products (RAGE) ligands through target directed dynamic combinatorial chemistry: a novel class of possible antagonists
Authors: Dascalu Anca‐Elena , Furman Christophe , Landrieu Isabelle , Cantrelle François‐Xavier , Mortelecque Justine , Grolaux Gaëlle , Gillery Philippe , Tessier Frédéric , Lipka Emmanuelle , Billamboz Muriel , Boulanger Eric , Ghinet Alina 
Published: February 2024

AbstractRAGE is a transmembrane receptor of immunoglobulin family that can bind various endogenous and exogenous ligands, initiating the inflammatory downstream signaling pathways, including inflammaging. Therefore, RAGE represents an attractive drug target for age‐related diseases. For the development of small‐molecule RAGE antagonists, we employed protein‐templated dynamic combinatorial chemistry (ptDCC) using RAGE′s VC1 domain as a template, the first application of this approach in the context of RAGE. The affinities of DCC hits were validated using microscale thermophoresis. Subsequent screening against AGE2 (glyceraldehyde‐modified AGE)‐sRAGE (solubleRAGE) (AGE2‐BSA/sRAGE) interaction using ELISA tests led to the identification of antagonists with micromolar potency. Our findings not only demonstrate the successful application of ptDCC on RAGE but also highlight its potential to address the pressing need for alternative strategies for the development of small‐molecule RAGE antagonists, an area of research that has experienced a slowdown in recent years.
Poly(vinyl chloride) Dechlorination Catalyzed by Zirconium
Authors: Normand Adrien T. , Wu Yue , Régnier Tiffanie , Fleurat‐Lessard Paul , Rousselin Yoann , Théron Benjamin , Le Gendre Pierre , Carta Mariolino 
Published: February 2024

AbstractPoly(vinyl chloride) undergoes dechlorination in the presence of triethylsilane (Et3SiH) and a catalytic amount of [Cp2Zr(NPh2)][CH3B(C6F5)3] (1 b) at 40–80 °C, with up to 91 % efficiency. Stoichiometric reactivity studies conducted on cyclohexyl chloride as a model suggest that 1 b dechlorinates PVC by initial chloride abstraction, followed by hydride transfer to the cationic PVC chain from Et3SiH. Consumer items such as pipe fitting, vinyl disc or electric cable insulation undergo either dechlorination or hydrosilylation of the carbonyl‐containing copolymer (polyvinyl acetate) or plasticizer (phthalate).
Exploring the Theoretical Foundations of Thermally Activated Delayed Fluorescence (TADF) Emission: A Comprehensive TD‐DFT Study on Phenothiazine Systems
Authors: Banerjee Moumita , Anoop Anakuthil 
Published: February 2024

AbstractThis study conducts a thorough theoretical investigation of Thermally Activated Delayed Fluorescence (TADF) in phenothiazine‐based systems, examining ten molecular configurations recognized experimentally as TADF‐active. Employing Time‐Dependent Density Functional Theory (TD‐DFT), our analysis spans the investigation of singlet‐triplet energy gaps (ΔEST), spin‐orbit coupling, and excitation characteristics using Multiwfn. This approach not only validates the adherence to El Sayed's rule across these systems but also provides a detailed understanding of charge transfer dynamics, as visualized through heat maps. A significant aspect of our study is the exploration of different oxidation states of sulfur and site substitutions on phenothiazine. This systematic variation aims to identify additional TADF‐active compounds, drawing parallels with properties characterizing other known TADF emitters. Our investigation into Reverse Intersystem Crossing (rISC) rates and the analysis of dihedral angles in relation to ΔEST values offer nuanced insights into the TADF behaviours of these molecules. By integrating rigorous computational analysis with practical implications, we provide a foundational understanding that enhances the design and optimization of phenothiazine‐based materials for optoelectronic applications. This work not only advances our theoretical understanding of TADF in phenothiazine derivatives but also serves as a guide for experimentalists and industry professionals in the strategic design of new TADF materials.
A Pd‐Catalyzed Annulation Strategy to Linearly Fused Functionalized N‐Heterocycles
Authors: Hoteite Larry , Allen Benjamin D. W. , Elhajj Ms. Ergaiya A. , Meijer Anthony J. H. M. , Harrity Joseph P. A. 
Published: February 2024

AbstractLinearly fused polycyclic piperidines represent common substructures in natural products and biologically active small molecules. We have devised a Pd‐catalyzed annulation strategy to these compounds that converts readily available 2‐tetralones and indanones into these scaffolds with the potential for control of both enantio‐ and diastereoselectivity. Importantly, these compounds can be chemoselectively functionalized, providing an efficient and robust methodology to these important nitrogen‐containing molecules.
Chiral acidic molecularly imprinted polymer for enantio‐separation of norepinephrine racemate
Authors: Abomuti May Abdullah 
Published: February 2024

AbstractWe are looking into how well a copolymeric material made of poly (maleic acid–co‐4‐vinylpyridine) cross‐linked with divinylbenzene can separate L‐norepinephrine (L‐NEP) from (±)‐NEP. The initial step in this direction was the synthesis and subsequent analysis of L‐NEP‐maleimide chiral derivative. A 4‐vinylpyridine/divinylbenzene combination was copolymerized with the resultant chiral maleimide. After heating the polymer materials in a high‐alkaline environment to breakdown the connecting imide bonds, they were acidified in an HCl solution to eliminate the incorporated L‐NEP species. Fourier transform infrared spectroscopy (FTIR) and a scanning electron microscope were used to examine the imprinted L‐NEP‐imprinted materials. The manufactured L‐NEP‐imprinted materials exhibited selectivity characteristics that were over 11 times greater for L‐NEP than D‐norepinephrine. The highest capacity observed in Langmuir adsorption studies was 170 mg/g at a pH of 7. After optical separation using a column technique, it was determined that the enantiomeric excess levels of D‐norepinephrine and L‐NEP in the first feeding and subsequent recovery solutions were 95% and 81%, respectively.
Effiziente Entgasung von keramischen Massen
Authors: Fahlbusch Fabian 
Published: February 2024

AbstractHöhere Qualität, weniger Wartung und geringere Kosten bei die Extruder‐Entgasung bilanzieren die Verantwortlichen in der Porzellanfabrik Hermsdorf in Thüringen. Das Unternehmen ersetzte vier alte, energie‐ und wartungsintensive ölgeschmierte Pumpen durch zwei energiesparende und wartungsarme trockene Vakuumsysteme zum Entgasen der Keramikmassen.
SAF auf Methanolbasis
Authors: Lisson Matthias 
Published: February 2024

AbstractWie alle Branchen muss auch die Luftfahrt ihre Emissionen drastisch senken. Netto‐Null ist nur mit alternativen Kraftstoffen zu erreichen. Wie alle Branchen muss auch die Luftfahrt ihre Emissionen drastisch senken. Nachhaltiges Flugbenzin (Sustainable Aviation Fuel, SAF) ist bereits verfügbar und nahezu universell einsetzbar. Ein Anlagenbauer will auf einem ehemaligen Flugplatz im brandenburgischen Jänschwalde eine Anlage zur Produktion von grünem Wasserstoff und umweltfreundlichem Flugzeugtreibstoff errichten. Das JANGADA genannte Projekt soll 2027 in Betrieb gehen.
Messtechnik für die Energiewende
Authors: Kraftschik Florian , Effenberger Frederik 
Published: February 2024

AbstractIm Rahmen der industriellen Energiewende muss der CO2‐Ausstoß verringert bzw. gänzlich vermieden und fossile Energieträger durch Strom und Wasserstoff ersetzt werden. Dazu benötigen Anlagenbetreiber nicht nur Messtechnik, um Messwerte und weitere Daten für die Prozessüberwachung und ‐steuerung zu erheben, sondern auch um präzise Informationen über Energieeinspeisung, ‐verbräuche und eine genaue Energiedistribution bis hin zur anlagenweiten Energiebilanzierung zu erfassen.
Diagnosing medullary thyroid carcinoma is facilitated by measuring calcitonin in FNA washout fluids: Alea iacta est
Authors: Trimboli Pierpaolo , Crescenzi Anna 
Published: February 2024

The prognosis for patients diagnosed with medullary thyroid carcinoma (MTC) varies significantly with the timing of detection: the earlier the diagnosis, the higher the likelihood of achieving a complete cure (or at least a better outcome). Ogmen et al. show that the routine measurement of calcitonin in serum could lead to an earlier MTC diagnosis.
Bioinformatics analysis proposes a possible role for long noncoding RNA MIR17HG in retinoblastoma
Authors: Wang Zijin , Liang Xiaotian , Yi Guoguo , Wu Tong , Sun Yuxin , Zhang Ziran , Fu Min 
Published: February 2024

AbstractBackgroundRetinoblastoma (RB) is the most common prevalent intraocular malignancy among infants and children, particularly in underdeveloped countries. With advancements in genomics and transcriptomics, noncoding RNAs have been increasingly utilized to investigate the molecular pathology of diverse diseases.AimsThis study aims to establish the competing endogenous RNAs network associated with RB, analyse the function of mRNAs and lncRNAs, and finds the relevant regulatory network.Methods and ResultsThis study establishes a network of competing endogenous RNAs by Spearman correlation analysis and prediction based on RB patients and healthy children. Enrichment analyzes based on Gene Ontology and the Kyoto Encyclopedia of Genes and Genomes are conducted to analyze the potential biological functions of lncRNA and mRNA networks. Weighted gene co‐expression network analysis (WGCNA) is employed to identify gene cluster modules exhibiting the strongest correlation with RB. The results indicate a significant correlation between the lncRNA MIR17HG (R = .73, p = .02) and the RB phenotype. ceRNA networks reveal downstream miRNAs (hsa‐mir‐425‐5p and hsa‐mir455‐5p) and mRNAs (MDM2, IPO11, and ITGA1) associated with MIR17Hg. As an inhibitor of the p53 signaling pathway, MDM2 can suppress the development of RB.ConclusionIn conclusion, lncRNAs play a role in RB, and the MIR17HG/hsa‐mir‐425‐5p/MDM2 pathway may contribute to RB development by inhibiting the p53 signaling pathway.
Population Pharmacokinetics of Fasinumab in Healthy Volunteers and Patients With Pain Due to Osteoarthritis of the Knee or Hip
Authors: Lin Kuan‐Ju , Turner Kenneth C. , Hassan Hazem E. , Harnisch Lutz O. , Davis John D. , DiCioccio Albert Thomas 
Published: February 2024

AbstractOsteoarthritis (OA) pain management options are currently limited. Fasinumab, an anti‐nerve growth factor monoclonal antibody, has been investigated in healthy volunteers and patients with OA‐related pain, among other conditions. Data from 12 Phase I‐III clinical trials of 92 healthy volunteers and 7430 patients with OA were used to develop a population pharmacokinetic model to characterize fasinumab concentration‐time profiles and assess the covariates’ effect on fasinumab pharmacokinetic parameters. Participants received single or repeated fasinumab doses intravenously (IV)/subcutaneously (SC), based on body weight (0.03‐1 mg/kg IV or 0.1‐0.3 mg/kg SC)/fixed dose (9‐12 mg IV or 1‐12 mg SC). Fasinumab concentration‐time data following IV and SC administration in healthy volunteers and patients with OA‐related pain were adequately described by a 2‐compartment model. Bioavailability increased with higher doses; estimated at 55.1% with 1 mg SC dose, increasing in a greater‐than‐proportional manner above this. Body weight had the largest predicted impact on fasinumab steady‐state exposures, participants at the 5th and 95th percentiles had a 43%‐45% higher/22%‐23% lower exposure versus reference, respectively. Other covariates had small but clinically irrelevant impacts.
Covalent Tethering of Cobalt Porphyrins on Phenolic Resins for Electrocatalytic Oxygen Reduction and Evolution Reactions
Authors: Kong Jiafan , Qin Haonan , Yang Luna , Zhang Jieling , Peng Yuxin , Gao Yimei , Wu Yizhen , Nam Wonwoo , Cao Rui 
Published: February 2024

AbstractUsing functionalized supporting materials for the immobilization of molecular catalysts is an appealing strategy to improve the efficiency of molecular electrocatalysis. Herein, we report the covalent tethering of cobalt porphyrins on phenolic resins (PR) for improved electrocatalytic oxygen reduction reaction (ORR) and oxygen evolution reaction (OER). A cobalt porphyrin bearing an alkyl bromide substituent was covalently tethered on phenolic resins, through the substitution reaction of alkyl bromides with phenolic hydroxyl groups, to afford molecule‐engineered phenolic resins (Co‐PR). The resulted Co‐PR was efficient for electrocatalytic ORR and OER by displaying an ORR half‐wave potential of E1/2=0.78 V versus RHE and an OER overpotential of 420 mV to get 10 mA/cm2 current density. We propose that the many residual phenolic hydroxyl groups on PR will surround the tethered Co porphyrin and play critical roles in facilitating proton and electron transfers. Importantly, Co‐PR outperformed unmodified PR and PR loaded with Co porphyrins through simple physical adsorption (termed Co@PR). The zinc‐air battery assembled using Co‐PR displayed a performance comparable to that using Pt/C+Ir/C. This work is significant to present phenolic resins as a functionalized material to support molecular electrocatalysts and demonstrate the strategy to improve molecular electrocatalysis with the use of phenolic resin residues.
Spontaneous Charge Separation at the Metal‐Water Interface
Authors: Svensson Rasmus , Grönbeck Henrik 
Published: February 2024

AbstractReactions at the metal‐water interface are essential in a range of fundamental and technological processes. Using Density Functional Theory calculations, we demonstrate that water substantially affects the adsorption of H and O2 on Cu(111), Ag(111), Au(111), Pd(111) and Pt(111). In water, H is found to undergo a spontaneous charge separation, where a proton desorbs to the water solution while an electron is donated to the surface. The reaction is exothermic over Au and Pt and associated with low barriers. The process is facile also over Pd, albeit slightly endothermic. For O2, water is found to increase the metal‐to‐adsorbate charge transfer, enhancing the adsorption energy and O−O bond length as compared to the adsorption in the absence of water. The magnitudes of the effects are system dependent, which implies that calculations should treat water explicitly. The results elucidate previous experimental results and highlights the importance of charge‐transfer effects at the metal‐water interface; both to describe the potential energy landscape, and to account for alternative reaction routes in the presence of water.
Advances in Membrane Mimetic Systems for Manipulation and Analysis of Membrane Proteins: Detergents, Polymers, Lipids and Scaffolds
Authors: Woubshete Menebere , Cioccolo Sara , Byrne Bernadette 
Published: February 2024

AbstractExtracting membrane proteins from the hydrophobic environment of the biological membrane, in a physiologically relevant and stable state, suitable for downstream analysis remains a challenge. The traditional route to membrane protein extraction has been to use detergents and the last 15 years or so have seen a veritable explosion in the development of novel detergents with improved properties, making them more suitable for individual proteins and specific applications. There have also been significant advances in the development of encapsulation of membrane proteins in lipid based nanodiscs, either directly from the native membrane using polymers allowing effective capture of the protein and protein‐associated membrane lipids, or via reconstitution of detergent extracted and purified protein into nanodiscs of defined lipid composition. All of these advances have been successfully applied to the study of membrane proteins via a range of techniques and there have been some spectacular membrane protein structures solved. In addition, the first detailed structural and biophysical analyses of membrane proteins retained within a biological membrane have been reported. Here we summarise and review the recent advances with respect to these new agents and systems for membrane protein extraction, reconstitution and analysis.
Bulk Heterojunction or Layer‐by‐Layer Structure PM6:L8‐BO Based Polymer Solar Cells Exhibiting an Efficiency of 17.84 % or 18.43 %
Authors: Zhang Junwei , Xu Wenjing , Tian Hongyu , Liu Zhongyuan , Zhang Fujun 
Published: February 2024

AbstractTwo kinds of polymer solar cells (PSCs) were fabricated with polymer donor PM6 and small molecule non‐fullerene acceptor L8‐BO as accepted based on bulk heterojunction (BHJ) or layer‐by‐layer (LbL) structure. The power conversion efficiency (PCE) of 18.43 % and 17.84 % can be achieved from the PSCs based on BHJ and LbL structure, respectively. Two kinds of PSCs exhibit the same open circuit voltage (VOC) of 0.88 V, which can be well explained from the same donor and acceptor materials and the same electrodes. The LbL based PSCs exhibit a relatively large short circuit current density (JSC) of 26.97 mA cm−2 and fill factor (FF) of 77.64 % in comparison with JSC of 26.64 mA cm−2 and FF of 76.07 % for BHJ based PSCs. The relatively high PCE of LbL based PSCs should be attributed to the sufficient exciton dissociation and charge collection efficiency, as well as the more balanced charge transport, which can be confirmed from the photogenerated current density dependence on the effective bias. This work demonstrates that layer‐by‐layer structure may have great potential in preparing highly efficient PSCs.