bluuebunny/crossref_metadata_2025_split huggingface dataset:
Integrating Sensor Networks to Facilitate Efficient Energy Management for Smart Grids
Authors: Baruah Arpita Nath , Akkur Malatesh S , Seth Jyoti , Shah Jaymeel 
Published: February 2024

Abstract
Due to rising energy prices and demand, many organizations are developing energy monitoring, management, and conservation systems. A SEMS supports Demand Side Management by producing consumer energy consumption patterns, reducing costsand responding to energy-saving instructions. Internet of Things (IoT) might regulate how much energy is consumed in the commercial, industrial and residential sectors. The study offers an intelligent energy management solution for smart settings that integrates an IoT middleware module and Energy Controller to regulate the demand side effectively. Every IoT device has an energy controller connected, incorporating sensors and actuators.The basis behind this isexterior temperature conditions,the building's operational dynamics, optimizing the air conditioners' energy usage, and the energy controller gathers data on energy usage from each smart device across various periods. Since air conditioners use more than 50% of the power in Pakistan, their use served as a proof of concept for the recommended method. The proposed solution incorporates real-time monitoring, powerful algorithms and user-friendly interfaces. Electricity consumption is compared before and after the installation of SEMS as part of the assessment procedure.Four constructs are used to evaluate the proposed methodology. The research highlights the system's key benefits and reveals significant energy savings. The smart energy management system provides better air conditioning system control, real-time monitoring, cost savings, environmental advantages, and longer equipment life.
Addressing the Knapsack Challenge Through Cultural Algorithm Optimization
Authors: Vahdatpour Mohammad Saleh 
Published: February 2024

Abstract
The "0-1 knapsack problem" stands as a classical combinatorial optimization conundrum, necessitating the selection of a subset of items from a given set. Each item possesses inherent values and weights, and the primary objective is to formulate a selection strategy that maximizes the total value while adhering to a predefined capacity constraint. In this research paper, we introduce a novel variant of Cultural Algorithms tailored specifically for solving 0-1 knapsack problems, a well-known combinatorial optimization challenge. Our proposed algorithm incorporates a belief space to refine the population and introduces two vital functions for dynamically adjusting the crossover and mutation rates during the evolutionary process. Through extensive experimentation, we provide compelling evidence of the algorithm's remarkable efficiency in consistently locating the global optimum, even in knapsack problems characterized by high dimensions and intricate constraints.
Knowledge Graph-based Multimodal GNN Model for Recommendation Systems
Authors: Sinclair Atticus , Callahan Juniper , Donovan Silas , Beckett Lawson 
Published: February 2024

Abstract
Knowledge graphs, recognized for their ability to amalgamate multiple data sources and enrich semantic information, have emerged as valuable auxiliary information. They offer the potential to infer latent relationships within data. However, existing knowledge graph-based recommendation systems often overlook the wealth of multimodal information. In response, this paper introduces a novel model designed to harness the propagation of information on multimodal knowledge graphs. Unlike its counterparts, our model actively considers the fusion of multimodal information, presenting a comprehensive solution to bridge the gap between recommendation systems and multimodal data. To evaluate the effectiveness of the proposed model, a comparative analysis with state-of-the-art models is conducted. The proposed model showcases promising results, demonstrating its efficacy in leveraging multimodal knowledge graphs. The empirical validation is performed on two real-world datasets, underscoring the potential impact of advancing the capabilities of contemporary recommendation systems.
The Prognosis and Management of Reclassified Systemic Lupus Erythematosus Associated Pulmonary Arterial Hypertension According to 2022 ESC/ERS Guidelines
Authors: Li Yutong , Qian Junyan , Dong Xingbei , Zhao Jiuliang , Wang Qian , Wang Yanhong , Zeng Xiaofeng , Tian Zhuang , Li Mengtao 
Published: February 2024

Abstract
Background and Aims:
The 2022 ESC/ERS guideline has recently revised the haemodynamic definition of pulmonary arterial hypertension. However, there is currently limited research on the prognosis and treatment of system lupus erythematosus associated pulmonary arterial hypertension (SLE-PAH) patients that reclassified by the new haemodynamic definition. This study aims to analyze the prognosis of newly reclassified SLE-PAH patients and provide recommendations for the management strategy.
Methods
This retrospective study analyze records of 236 SLE-PAH patients who visited Peking Union Medical College Hospital (PUMCH) from 2011 to 2023, among whom 22 patients were reclassified into mild SLE-PAH (fulfilling the criteria of 2022 ESC/ERS guideline [mean pulmonary arterial pressure (mPAP) ≥ 21mmHg and pulmonary vascular resistance (PVR) > 2WU] but not the previous haemodynamic criteria [mPAP ≥ 25mmHg and PVR > 3WU]) according to the guideline and 14 were defined as partially remitted patients (mPAP 21–24 mmHg and PVR < 2 WU). The prognosis were compared among mild SLE-PAH, partially remitted SLE-PAH and conventional SLE-PAH patients (mPAP ≥ 25mmHg and PVR > 3WU). Besides, the effectiveness of pulmonary arterial hypertension (PAH) targeted therapy was evaluated in mild SLE-PAH patients.
Results
Those mild SLE-PAH patients had significantly longer progression-free time than the conventional SLE-PAH patients, and the mild SLE-PAH patients had similar prognosis compared to partially remitted patients. Among the mild SLE-PAH patients, 4 did not receive PAH targeted therapy of PAH and had similar prognosis with patients not receiving targeted therapy. Besides, nearly all of the reclassified SLE-PAH patients received intensive immunosuppressive therapy (IIT).
Conclusions
This study supports the revised haemodynamic definition of SLE-PAH in the 2022 ESC/ERS guideline. Those reclassified mild and partially remitted SLE-PAH patients had better prognosis, demonstrating the possibility and significance of early diagnosis and intervention for SLE-PAH. This study also suggested that IIT against SLE might be sufficient for those reclassified SLE-PAH patients.
NLRC3 as a Potential Therapeutic Target for Acute Lung Injury: Insights from Acacetin Studies
Authors: xiao yingchou , zhang bo , hou shiyuan , shen xing , wu xingan , liu rongrong , luo ying 
Published: February 2024

Abstract
Acute lung injury (ALI) is a severe condition characterized by respiratory insufficiency and tissue damage. Commonly caused by pneumonia and severe sepsis, which trigger an inflammatory response via Toll-like receptor 4 (TLR4) signaling activation. Nod-like receptor family CARD domain containing 3 (NLRC3), a member of the NLR family, modulates inflammation and immune responses by inhibiting NF-κB, activation in response to TLR4 activation. Dysregulation of NLRC3 has been linked to increased susceptibility to inflammatory diseases. In the context of ALI, overexpression of NLRC3 reduces lung inflammation, while its silencing exacerbates inflammation. Acacetin, a flavonoid from Agastache rugosa, exhibits anti-inflammatory properties and has been suggested to involve NLRC3 in its mechanism. Silencing NLRC3 abolishes the protective effect of acacetin on LPS-induced inflammation in macrophages. Moreover, NLRC3 negatively regulates TLR4 signaling, which is involved in lipopolysaccharide (LPS)-induced inflammation. Acacetin has been reported to inhibit TLR4 signaling in various cell types. Thus, acacetin's anti-inflammatory effects may be partly mediated by its modulation of NLRC3 expression and function. In this study, our objective was to investigate the potential targets and functional mechanisms of acacetin in combating ALI. We employed molecular docking technology to anticipate and authenticate the interaction between acacetin and NLRC3. The findings were subsequently validated using an ALI model and LPS-induced macrophage model.
Will a lack of fabric durability be their downfall? Impact of textile durability on the efficacy of three types of dual-active-ingredient long-lasting insecticidal nets: A secondary analysis on malaria prevalence and incidence from a cluster-randomized trial in north-west Tanzania
Authors: Lukole Eliud , Cook Jackie , Mosha Jacklin F , Mallya Elizabeth , Aziz Tatu , Kulkarni Manisha A , Matowo Nancy S , Martin Jacklin , Rowland Mark , Kleinschmidt Immo , Manjurano Alphaxard , Mosha Franklin W , Protopopoff Natacha 
Published: February 2024

Abstract
Background
The Dual-Active Ingredient long-lasting insecticidal nets (Dual-AI LLIN) have been developed to counteract the reduced efficacy of pyrethroid (PY)-only nets due to widespread pyrethroid insecticide resistance in malaria vector mosquitoes. They constitute half of the nets distributed in sub-Saharan Africa in the past two years. However, their effectiveness once they develop holes is unclear, particularly in pyrethroid-resistant settings. This study evaluates the textile integrity of three dual- AI LLINs compared to standard PY LLN, over 3 years of use in a community in Tanzania and the associated impact on malaria prevalence and incidence.
Methods
Between 2019 and 2022, we conducted a secondary analysis of data from a randomized controlled trial (RCT) in North-western Tanzania to evaluate the effectiveness of α-cypermethrin only; pyriproxyfen and α-cypermethrin (PPF-PY); chlorfenapyr and α-cypermethrin (chlorfenapyr-PY); and the synergist piperonyl butoxide and permethrin (PBO-PY) LLINs on malaria infection prevalence and case incidence. We assessed the association between the net textile condition and 1/malaria prevalence over 3 years of use, and 2/malaria case incidence in a cohort of children over 2 years of follow-up.
Results
There was no significant association between damaged (OR: 0.98, 95%CI: 0.71-1.37, p-value=0.6550) and too-torn (OR: 1.07, 95%CI: 0.77-1.47, p-value=0.6940) compared to intact nets on malaria prevalence for all net types. However, there were reduced rates of malaria case incidence in children sleeping under a net in good condition compared to extremely torn nets (incidence rate ratio (IRR) 0·76 [95%CI: 0.63-0.92], p=0.0047). Malaria incidence was also consistently lower in too-torn PBO-PY LLIN (IRR= 0.37 [95%CI: 0.19-0.72], p= 0.0033) and Chlorfenapyr-PY LLIN (IRR= 0.45 [95%CI: 0.33-0.97], p= 0.0525) compared to a intact PY-only LLIN during the first year of follow up. In year 2, the incidence was only significantly lower in intact Chlorfenapyr-PY LLIN (IRR= 0.49 [95%CI: 0.29-0.81], p= 0.0059) compared to intact PY LLIN.
Conclusion
Our study confirmed that sleeping under a Chlorfenapyr-PY LLIN or PBO-PY LLIN offered superior protection to pyrethroid-only nets even when torn. Preventing the development of holes is essential as they impact the level of protection offered against malaria infection.
Trial registration
ClinicalTrials.gov, number (NCT03554616)
Pós transplante de células tronco hematopoiética: análise de custos das infecções no primeiro ano de transplante
Authors: Afonso Lucélia Rodrigues , Nobre Stefane Vieira , Da Silva Marcelo Gurgel Carlos 
Published: February 2024

Objetivos: Analisar os custos das infecções no primeiro ano pós-transplante de células-tronco hematopoiéticas. Métodos: Estudo transversal analítico desenvolvido através dos dados de pacientes que tiveram diagnóstico de câncer hematológico e foram submetidos ao transplante de células-tronco hematopoiéticas no primeiro ano de transplante, que realizaram transplante de células-tronco hematopoiéticas no ano de 2018 com idade igual ou superior a 18 anos. Foram realizadas análises descritivas e de correlação entre as variáveis. Resultados: Dos 71 pacientes, 36 apresentaram infecções. A maior média de gasto foi para os tipos haploidênticos (44% versus 9%, p<0,001) e com relação à doença de base, o grupo que apresentou infecções tinha maior frequência de leucemias (42% versus 14%, p=0,012). Parâmetros relacionados ao mal prognóstico como, três ou mais internações (22% versus 3%, p=0,04), maior tempo de permanência no hospital (22,5 [AIQ= 21 – 55] versus 19 [AIQ=16 – 23] dias, p<0,001) e maior frequência de óbito (42% dessas 14%, p=0,01), tiveram relacionados com a presença de infecção. O grupo que tem infecções apresentou uma mediana alta em relação ao grupo que não teve infecções (5 5519,8 (25 618,8 – 73 806,6) versus 23 872,5 (23 657,7 – 24 927,6) reais, p<0,001). Conclusões: As infecções representam um dos principais obstáculos no sucesso dos transplantes, com elevada quantidade de pacientes que foram a óbito e que desenvolveram complicações, onerando os custos com internações e procedimentos.
The Abbasid State's Contribution to Education: History, Policy, and Development of Islamic Educational Institutions
Authors: Ichsan Yazida , Hanafiah Yusuf , Fadhlurrahman Fadhlurrahman , Okfia Supitri 
Published: February 2024

This study aims to describe the contribution of Abbasid civilization to education both covering Abbasid history, policies related to scientific development, and developing educational institutions. This research is a literature research by emphasizing historical aspects with heuristics, criticism, interpretation and histography steps. The results of the study showed that there were several policies implemented by the government to develop science and civilization which included translation projects, rihlah 'ilmiyyah and the construction of educational institutions which included libraries, kuttab, mosques, madrasas, art studios, bookstores, observatories, ribath and zawiyyah. When contextualized with Islamic education today, there are several alternatives offered by the Abbasid State. First, in addition to using a normative approach, an experimental approach in education is needed as a solutive alternative to facing industrial challenges. Second, to form educated people, there needs to be a synergy of all elements, not just educational institutions. Third, Islamic educational institutions must have a concentration in certain sciences on the basis of Islamic norms.
Clinical Outcomes and Effectiveness of CRLX101 for Solid Tumors:
A Systematic Review and Meta-analysis
Authors: Shamaeizadeh Nahal , Sadeghi Erfan , Varshosaz Jaleh 
Published: February 2024

Background::
While it has been demonstrated that delivery of cytotoxic chemotherapy
using nanoparticles greatly improves patient drug tolerance and reduces toxicity
when compared to the standard formulation, the crucial question of whether they also
increase anticancer efficacy remains. The CRLX101 is a nanoparticle composed of cyclodextrin
and 20(S)-camptothecin cytotoxic chemotherapy

Objective::
In order to compare the efficacy of the CRLX101 to its corresponding traditional
formulation, we carried out this systematic literature search for randomized clinical
and non-randomized trials.

Methods::
Multiple electronic databases, including PubMed, Scopus, Embase, Web of
Science, the Cochrane Library, and clinicaltrials.gov, were used to conduct a thorough
literature search. By employing a technique akin to a random-effects model, the median
of the study-specific was taken into account as the pooled median estimate with a 95%
confidence interval.

Results::
Finally, nine clinical studies were chosen for the meta-analysis. The treatment
and control groups' overall survival were examined in five and three trials, respectively.
Additionally, six out of nine trials and two out of nine trials, respectively, examined the
treatment and control groups for progression-free survival (PFS). Meta-analysis revealed
that the treatment group had a lower median overall survival (OS) but a greater
median progression-free survival than the control group.

Conclusion::
Our meta-analysis shows that CRLX101 outperforms camptothecin in PFS
despite its inferior OS. Unresolved pharmacology limits carrier-mediated drug therapeutic
application. Carrier-mediated dosages may differ from normal formulations because
they are rarely studied.
Icariin Attenuates Human Renal Tubular Epithelial Cell Senescence by Targeting PAK2 via miR-23b-3p
Authors: Zhang Suqin , Li Yanbin , Wang Qiuyue 
Published: February 2024

Background:
Renal tubular epithelial cells (RTECs) senescence is crucial in kidney
diseases. Icariin is shown to have protective effects against renal fibrosis, acute kidney injury,
and proteinuria. We aimed to explore the role of icariin in protecting RTECs from senescence
and the underlying mechanism involved.

Methods:
An in vitro model of RTEC senescence was established by incubating HK-2 cells with
urine exosomes from patients with diabetic kidney disease. Stimulated cells were treated with
icariin at various doses to evaluate the compound's therapeutic effects. After RNA transfection,
cell cycle arrest and senescence, flow cytometry, and SA-β-Gal staining were analyzed. At the
same time, quantitative real-time PCR examined microRNA expression. Biochemical assays.

Results:
Urine exosomes induced senescence and cell cycle arrest in the G1 stage in HK-2 cells,
which were inhibited by icariin. Urine exosome stimulation up-regulated miR-23b-3p expression,
which in turn suppressed PAK2 expression. Significantly, the induced and inhibited miR-
23b-3p expressions weakened and augmented the resistance of cells against urine exosome stimulation,
respectively, while PAK2 overexpression provided additional protection. Icariin suppressed
miR-23b-3p expression, and miR-23b-3p induction blocked the effects of icariin and
promoted RTEC senescence.

Conclusion:
miR-23b-3p and PAK2 form a signaling axis that regulates RTEC senescence upon
urine exosome stimulation. Icariin can increase the resistance of RTECs against senescence via
miR-23b-3p/PAK2. Our findings shed light on the mechanism of the clinical effects of icariin on
renal diseases, which can be exploited to develop effective drugs targeting RTEC senescence in
the future.

conclusion:
miR-23b-3p and PAK2 form a signaling axis that regulates RTEC senescence upon urine exosome stimulation. Icariin can increase the resistance of RTECs against senescence via miR-23b-3p/PAK2. Our findings shed light on the mechanism of the clinical effects of icariin on renal diseases, which can be exploited for the development of effective drugs targeting RTEC senescence in the future.
Construction of an Oxidative Stress Risk Model to Analyze the Correlation Between Liver Cancer and Tumor Immunity
Authors: Liu Ying , Li Yufeng , Chen Li , Zha Weina , Zhang Jing , Wang Kun , Hao Chunhai , Gan Jianhe 
Published: February 2024

Background:
Hepatocellular carcinoma (HCC) remains one of the most lethal cancers
globally. Despite advancements in immunotherapy, the prognosis for patients with HCC continues
to be poor. As oxidative stress plays a significant role in the onset and progression of various diseases,
including metabolism-related HCC, comprehending its mechanism in HCC is critical for effective
diagnosis and treatment.

Methods:
This study utilized the TCGA dataset and a collection of oxidative stress genes to determine
the expression of oxidative stress-related genes in HCC and their association with overall survival
using diverse bioinformatics methods. A novel prognostic risk model was developed, and
the TCGA cohort was divided into high-risk and low-risk groups based on each tumor sample's
risk score. Levels of immune cell infiltration and the expression of immune checkpoint-related
genes in different risk subgroups were analyzed to investigate the potential link between tumor immunity
and oxidative stress-related features. The expression of model genes in actual samples was
validated through immunohistochemistry, and their mRNA and protein expression levels were
measured in cell cultures.

Results:
Four oxidative stress-related genes (EZH2, ANKZF1, G6PD, and HMOX1) were identified
and utilized to create a predictive risk model for HCC patient overall survival, which was subsequently
validated in an independent cohort. A significant correlation was found between the expression
of these prognostic genes and the infiltration of tumor immune cells. Elevated expression
of EZH2, ANKZF1, G6PD, and HMOX1 was observed in both HCC tissues and cell lines.

Conclusion:
The combined assessment of EZH2, ANKZF1, G6PD, and HMOX1 gene expression
can serve as a model to evaluate the risk of oxidative stress in HCC. Furthermore, there is a
notable correlation between the expression of these risk model genes and tumor immunity.
Newly Described Mutations of the UNC45A Gene in Infants with Jaundice and Pruritus
Authors: Degtyareva Anna , Dokshukina Alina , Filippova Elena , Shubina Jekaterina , Tolmacheva Ekaterina , Sadelov Igor , Albegova Marina , Degtyarev Dmitriy 
Published: February 2024

Background:
Cholestatic liver disease is an important cause of morbidity and mortality
and a leading indication for liver transplantation in children. These include diseases, such as
biliary atresia, Alagille syndrome, progressive familial intrahepatic cholestasis, sclerosing cholangitis,
bile acid synthesis defects, and many others.

Case Presentation:
NGS was used as a diagnostic tool to identify the genetic cause in the patient
with cholestatic syndrome and to figure out and describe what mutation will be found. In the present
observation, the cholestasis syndrome with low GGT activity and intense pruritus was the
leading symptom of the patient. The examination also revealed other characteristic features of osteo-
oto-hepato-enteric syndrome. The patient had facial features that mimicked Alagille syndrome,
which complicated the diagnostic search. Moreover, the genetic test revealed two new
pathogenic variants in the UNC45A gene.

Conclusion:
This clinical observation demonstrates the importance of a multidisciplinary approach
in the diagnosis of rare genetic diseases and using WES, which can accelerate the diagnosis
compared with outdated gene panels.
lkGraphene Nano-Derivatives in Pharmaceuticals and Biomedical Advancements: A Comprehensive Review
Authors: Kumar Yogesh , Sharma Astha , Varshney Prachi , Yadav Devdhar , singh Amit , Rani Kagithala Naga , Sharma Pramod , Porwal Omji , Kumar Neeraj , Kumar Sharma Pradeep , Kumar Gupta Ashok , G Koteswara Rao 
Published: February 2024

Abstract:
The two-dimensional structure of graphene has a flat single layer of carbon molecules
having a honeycomb crystal lattice configuration. Graphene possesses typical physicochemical
characteristics such as elevated conductivity, wide-ranging surface area, good biocompatibility,
and excellent mechanical properties. Due to their exceptional properties, graphene derivatives have
significant implementations in many fields like electronics, environmental, chemical, pharmaceutical,
and others. With its distinctive formation and biological characteristics, pharmaceutical and
biomedical applications of graphene have gained the impressive interest of researchers and scientists
over the past few years. The exceptional properties of graphene, such as its larger surface area,
which is four times greater than other nanoparticles, represented it as a prior choice for drug delivery.
Graphene derivatives are monolayer graphene, bilayer graphene, reduced Graphene Oxide
(rGO), and Graphene Oxide (GO). This review focused on different pharmaceutical applications
and the part of the progress made by different researchers on graphene and its derivatives in the
distinct field of interest, like in the delivery of drugs, cancer therapy, gene delivery, antibacterial
effect, biosensing, bioimaging, tissue engineering, and others.