bluuebunny/crossref_metadata_2025_split huggingface dataset:
Spectral pyrometry of non-metallic materials at plasma heating, melting and cooling (Tomsk)
Authors: Shekhovtsov V. V. 
Published: October 2023

Spectral pyrometry of non-metallic materials under plasma heating, melting and cooling is used in nanotechnology, medicine, energy, metallurgy and other industries, where accurate temperature control is required during processing various materials. Purpose: The aim of this work is to create new spectral pyrometry technique for temperature measurement in difficult conditions of material processing and synthesis, such as plasma heating, melting and cooling of non-metallic materials. Methodology/approach: Small-sized spectrometers for diagnostics of heating, melting and cooling of the quartz target using the plasma jet. HPCS300 Mini Spectrometer with the wavelength range of 380 to 780 nm is used to determine the color temperature of the reference radiation source and for fiber optic calibration. The STS-VIS Microspectrometer based on a 1024×1 element CCD photodetector array with the wavelength range of 350 to 800 nm is used to record the emission spectrum of the object. Research findings: Improvement of production processes, fuel and material cost reduction, increase in the efficiency of plants and equipment, reliability and quality improvement of the final product. Value: During the plasma jet and quartz target interaction, three stages are observed: surface deformation, stable temperature of heating, and cooling of the condensed material with phase-transition points of liquid–pyroplastic–solid states.
Model of Building Maintenance Planning Using The Building Information Modeling (BIM)
Authors: Soetjipto Jojok Widodo , Zarkasi Ilham Kahfi , Trisiana Anita 
Published: October 2023

Building maintenance is essential for the operation of the building to maintain the reliability and performance of the building to match its economic age. There are many buildings whose maintenance is inferior from a technical, administrative, and budgetary perspective, so an appropriate maintenance design model is needed according to the operational needs of the building. On the other hand, the development of digital information technology is getting faster and more widely used. One is Building Information Modeling (BIM), where the entire activity process works in collaboration and integration. Therefore, this study aims to develop a proper building maintenance design model using BIM. The method used is to apply building maintenance standards in Indonesia (Public Works Ministrial Regulation No 24/PRT/M/2008) in BIM supporting applications, namely Autodesk Revit (for visualizing 3D buildings) and Autodesk BIM 360 Ops (for maintenance management), as a case study using the Maintenance Management Design of Walini Station which is one of the Jakarta-Bandung fast train stations with very modern, complex and complicated building components. The maintenance design model is carried out through the following stages: (i) building modeling using Autodesk Revit based on shop drawings in 3D and can be applied to 4D and 5D needs; (ii) export Autodesk Revit results to the Autodesk BIM 360 Ops application because this application can store a database of all building operations; and (iii) conducting a maintenance design simulation using the Autodesk BIM 360 Ops application. The study results show that BIM technology can be used as a detailed, accurate, effective, efficient, and integrated maintenance design model.
Keywords: Building Maintenance, Building Information Modeling (BIM), Autodesk Revit, Autodesk BIM 360 Ops, building maintenance model
Problematic Smartphone Use Among High School Students
Authors: Spiratos Kiva , Ratanasiripong Paul 
Published: October 2023

The world currently has more than three billion smartphone users. The smartphone is fully integrated into the daily life of individuals, including 95% of American teenagers. Excessive use of the smartphone leads to smartphone addiction and problematic smartphone use (PSU) which has been associated with depression, stress, reduced self-esteem, and decreased academic performance. This PSU study surveyed high school students grades nine thru twelve from a comprehensive and demographically diverse high school in the United States. This study was conducted with 319 high school students to assess for associations among PSU, depression, stress, self-esteem, grit, and academic performance. Results of this study indicated that students use the smartphone to support learning both inside and outside of the classroom. Results also indicated significant correlations among PSU, depression, stress, self-esteem, grit, and academic performance. Multiple regression analysis found stress, self-esteem, and grit to be significant predictors of PSU. Implications of this study included informing families, educators, district administrators, and policymakers to more fully and rigorously utilize the electronic device policy provided in California Assembly Bill 272 and to implement more robust and thoughtful classroom smartphone policies and practices. Recommendations are to continue to assess and build awareness of PSU among adolescents, especially post COVID-19 pandemic, when interpersonal relationships and personal connections are a focus of social emotional pandemic recovery.
Unravelling the sexual developmental biology of Cystoisospora suis, a model for comparative coccidian parasite studies
Authors: Cruz-Bustos Teresa , Dolezal Marlies , Feix Anna Sophia , Ruttkowski Bärbel , Hummel Karin , Razzazi-Fazeli Ebrahim , Joachim Anja 
Published: October 2023

IntroductionThe apicomplexan parasite Cystoisospora suis has global significance as an enteropathogen of suckling piglets. Its intricate life cycle entails a transition from an asexual phase to sexual development, ultimately leading to the formation of transmissible oocysts.MethodsTo advance our understanding of the parasite’s cellular development, we complemented previous transcriptome studies by delving into the proteome profiles at five distinct time points of in vitro cultivation through LC/MS-MS analysis.ResultsA total of 1,324 proteins were identified in the in vitro developmental stages of C. suis, and 1,082 proteins were identified as significantly differentially expressed. Data are available via ProteomeXchange with identifier PXD045050. We performed BLAST, GO enrichment, and KEGG pathway analyses on the up- and downregulated proteins to elucidate correlated events in the C. suis life cycle. Our analyses revealed intriguing metabolic patterns in macromolecule metabolism, DNA- and RNA-related processes, proteins associated with sexual stages, and those involved in cell invasion, reflecting the adaptation of sexual stages to a nutrient-poor and potentially stressful extracellular environment, with a focus on enzymes involved in metabolism and energy production.DiscussionThese findings have important implications for understanding the developmental biology of C. suis as well as other, related coccidian parasites, such as Eimeria spp. and Toxoplasma gondii. They also support the role of C. suis as a new model for the comparative biology of coccidian tissue cyst stages.
Untangling the relationship between bempedoic acid and gout: results from a systematic literature review
Authors: Alunno Alessia , Carubbi Francesco , Campanozzi Elena , Bellisario Federico , Schoones Jan W. , Mariani Francesco Maria , Di Ruscio Evy , Altieri Piera , Ferri Claudio 
Published: October 2023

BackgroundBempedoic acid (BA) is a small-molecule first-in-class of inhibitor of ATP citrate lyase that significantly lowers low-density lipoproteins cholesterol (LDL-c) in statin-intolerant and inadequate responders. Increased serum uric acid (SUA) levels and gout incidence have been described in BA-treated patients. The aim of this systematic review was to investigate the safety of BA regarding SUA levels and gout in randomised controlled trials (RCTs).MethodsA search on 7 databases was performed from inception to May 4, 2023. RCTs of BA monotherapy or combination with other lipid-lowering treatment (LLT) in patients with increased LDL-c were included. Dual data extraction was performed with disagreements resolved through consensus. Due to the methodological purpose of this review risk-of-bias assessment of studies was not performed.Results6 Phase 3 RCTs (N = 17,975 patients of which 9,635 received BA) 9 Phase 2 RCTs (N = 362 patients of which 170 received BA) and an open-label extension of a Phase 3 RCT were included. Gout and/or hyperuricemia were not mentioned as exclusion criteria, previous/current use of urate-lowering therapies (ULT) and/or colchicine and/or dietary patterns were not reported. Phase 3 RCTs: 2 studies specified the number of patients experiencing hyperuricemia over the study period (BA: 4.9%–11%; placebo: 1.9%–5.6%) and the effect size was significant only in 1 study (OR = 2.0, 95% CI 1.8–2.3). Four RCTs reported a higher incidence of gout in the BA arm however, when we calculated the effect size, it was small and often not significant. Two studies reported 0 cases of gout. The paucity of information about SUA levels at baseline and/or at the end of follow-up do not allow us to quantify the effect sizes for BA-induced SUA elevation. Data on gout from Phase 2 RCTs is scant.ConclusionsData from phase 2 and 3 RCTs do not allow for confirming a clear association between BA and gout. It is conceivable that a careful assessment of SUA levels/history of gout at baseline and the concomitant use of urate-lowering agents may be instrumental to minimise the risk of new-onset gout/gout flares in patients treated with BA.
Influence of chronic kidney disease and its severity on the efficacy of semaglutide in type 2 diabetes patients: a multicenter real-world study
Authors: García de Lucas María Dolores , Caballero Irene , Fernández-García José Carlos , Domínguez-Rodríguez Manuel , Moreno-Moreno Paloma , Jiménez-Millán Anabel , Botana-López Manuel , Avilés Beatriz , Merino-Torres Juan Francisco , Soto Alfonso , Tejera Cristina , Morales Cristóbal 
Published: October 2023

ObjectivesSemaglutide is a glucagon-like peptide 1 receptor agonist that improves glycemic control and achieves weight loss in type 2 diabetes (T2D) patients. Subcutaneous (s.c.) semaglutide at 1 mg once weekly (OW) is safe in T2D patients with chronic kidney disease (CKD). Whether or not CKD and its severity influence treatment response remains undetermined.MethodThis is an observational, ambispective, multicenter, nationwide, real-world study designed to compare safety/efficacy of OW s.c. 1 mg semaglutide in T2D patients with or without CKD. The influence of CKD severity was also addressed. Patients were followed up for 12 months. Primary end-points were glycosylated hemoglobin (HbA1c), weight, and renal outcomes. Secondary end-points included insulin resistance, atherogenic and hepatic steatosis indexes, and changes in antihyperglycemic medications.ResultsA total of 296 and 190 T2D patients without or with CKD, respectively, were recruited. Baseline CKD risk was moderate, high, or very high in 82, 53, and 45 patients, respectively. Treatment reduced HbA1c by 0.90%–1.20%. Relevant differences were seen neither between non-CKD and CKD patients nor among CKD subgroups. Notable weight losses were achieved in both non-CKD and CKD patients. The median reduction was higher in the former at 6 months (5.90 kg vs. 4.50 kg, P = 0.008) and at end of study (6.90 kg vs. 5.00 kg, P = 0.087). A trend toward slightly lower weight losses as CKD severity increased was observed. CKD markers improved across all CKD subgroups. Relevant differences were not observed for other variables, either between non-CKD and CKD patients, or among CKD subgroups. Safety concerns were not reported.ConclusionThe safety/efficacy of OW s.c. semaglutide to improve glycemic control and weight in T2D patients with CKD is not notably lower than that in T2D patients without renal failure. CKD severity barely influences treatment response. OW s.c. semaglutide can be useful to manage T2D patients with CKD in daily clinical practice.
Genetically predicted levels of circulating cytokines and the risk of six immune skin diseases: a two-sample Mendelian randomization study
Authors: Luo Qinghua , Cao Qiurui , Guo Jinyan , Chang Shuangqing , Wu Yunxiang 
Published: October 2023

BackgroundCirculating cytokines play a crucial role in the onset and progression of immune skin diseases. However, the causal relationships and the direction of causal effects require further investigation.MethodsTwo-sample Mendelian randomization (MR) analyses were conducted to assess the causal relationships between 41 circulating cytokines and six immune skin diseases including alopecia areata, chloasma, hidradenitis suppurativa (HS), lichen planus (LP), seborrheic dermatitis, and urticaria, using summary statistics from genome-wide association studies. Reverse MR analyses was performed to test for the reverse causation. Pleiotropy and heterogeneity tests were conducted to assess the robustness of the findings.ResultsTwelve unique cytokines showed a suggestive causal relationship with the risk of six immune skin diseases. Among them, the causal effects between 9 unique cytokines and immune skin diseases have strong statistical power. Additionally, the concentrations of six cytokines might be influenced by LP and urticaria. After Bonferroni correction, the following associations remained significant: the causal effect of beta-nerve growth factor on HS (odds ratio [OR] = 1.634, 95% confidence interval [CI] = 1.226-2.177, p = 7.97e-04), interleukin (IL)-6 on LP (OR = 0.615, 95% CI = 0.481-0.786, p = 1.04e-04), IL-4 on LP (OR = 1.099. 95% CI = 1.020-1.184, p = 1.26e-02), and IL-2 on urticaria (OR = 0.712, 95% CI = 0.531-0.955, p = 2.33e-02).ConclusionThis study provides novel perspectives on the relationship between circulating cytokines and immune skin diseases, potentially providing valuable insights into their etiology, diagnostic approaches, and treatment.
Emerging insights into inflammatory bowel disease from the intestinal microbiota perspective: a bibliometric analysis
Authors: Zhang Anqi , Wang Fang , Li Delong , Wang Chong-Zhi , Yao Haiqiang , Wan Jin-Yi , Yuan Chun-Su 
Published: October 2023

BackgroundInflammatory bowel disease (IBD) has caused severe health concerns worldwide. Studies on gut microbiota have provided new targets for preventing and treating IBD. Therefore, it is essential to have a comprehensive understanding of the current status and evolution of gut microbiota and IBD studies. MethodsA bibliometric analysis was performed on documents during 2003-2022 retrieved from the Scopus database, including bibliographical profiles, citation patterns, and collaboration details. Software programs of VOSviewer, CiteSpace, and the Bibliometrix R package visually displayed the mass data presented in the scientific landscapes and networks. Results10479 publications were retrieved, showing a steadily growing tendency in interest. Xavier Ramnik J. group led the total number of publications (73 papers) and 19787 citations, whose productive work aroused widespread concern. Among the 1977 academic journals, the most prolific ones were Inflammatory Bowel Diseases, Frontiers in Immunology, and Nutrients. Research outputs from the United States (US, 9196 publications), China (5587), and Italy (2305) were highly ranked.ConclusionOur bibliometric study revealed that the role of gut microbiota has become a hot topic of IBD research worldwide. These findings are expected to improve understanding of research characteristics and to guide future directions in this field.
Neural control of redox response and microbiota-triggered inflammation in Drosophila gut
Authors: Fuse Naoyuki , Hashiba Haruka , Ishibashi Kentaro , Suzuki Takuro , Nguyen Quang-Dat , Fujii Kiho , Ikeda-Ohtsubo Wakako , Kitazawa Haruki , Tanimoto Hiromu , Kurata Shoichiro 
Published: October 2023

BackgroundThe neural system plays a critical role in controlling gut immunity, and the gut microbiota contributes to this process. However, the roles and mechanisms of gut-brain-microbiota interactions remain unclear. To address this issue, we employed Drosophila as a model organism. We have previously shown that NP3253 neurons, which are connected to the brain and gut, are essential for resistance to oral bacterial infections. Here, we aimed to investigate the role of NP3253 neurons in the regulation of gut immunity.MethodsWe performed RNA-seq analysis of the adult Drosophila gut after genetically inactivating the NP3253 neurons. Flies were reared under oral bacterial infection and normal feeding conditions. In addition, we prepared samples under germ-free conditions to evaluate the role of the microbiota in gut gene expression. We knocked down the genes regulated by NP3253 neurons and examined their susceptibility to oral bacterial infections.ResultsWe found that immune-related gene expression was upregulated in NP3253 neuron-inactivated flies compared to the control. However, this upregulation was abolished in axenic flies, suggesting that the immune response was abnormally activated by the microbiota in NP3253 neuron-inactivated flies. In addition, redox-related gene expression was downregulated in NP3253 neuron-inactivated flies, and this downregulation was also observed in axenic flies. Certain redox-related genes were required for resistance to oral bacterial infections, suggesting that NP3253 neurons regulate the redox responses for gut immunity in a microbiota-independent manner.ConclusionThese results show that NP3253 neurons regulate the appropriate gene expression patterns in the gut and contribute to maintain homeostasis during oral infections.
Changes in species compositions of fish in the bays of the Northwestern Gulf of Mexico
Authors: Torres Ceron Milton , Fujiwara Masami , Martinez-Andrade Fernando 
Published: October 2023

IntroductionLocal biodiversity is increasing in many temperate and subtropical waters due to climate change. It is often caused by shifting fish distributions, thus the biodiversity gradient, from lower to higher latitudes. However, these shifts in distributions do not occur uniformly across all species. Consequently, communities are not only shifting their spatial distributions, but species compositions are also changing. We investigated spatiotemporal differences in the compositions of fish species in the bays of the northeastern Gulf of Mexico and identified species that contribute to the temporal changes.MethodsWe used fish count data collected using gillnets in eight major bays, encompassing over 600 km of coastline, during spring and fall seasons from 1982 to 2019. The nonmetric multidimensional scaling (NMDS) on the Bray-Curtis dissimilarity index among species composition vectors was used to detect the differences in species composition, and the similarity percentages (SIMPER) were used to determine the contribution of species to the differences. ResultsThe result shows there was a gradual change in species composition in all bays over the years, and the composition was different among bays and seasons. The species contributing to the temporal changes included those that are expanding (e.g., Common snook, Centropomus undecimalis, and Smallscale fat snook, C. parallelus) as well as retracting (e.g., Southern flounder, Paralichthys lethostigma, and Spanish mackerel, Scomberomorus maculatus) their distributions toward the north. The species observed only in recent years in these bays tended to have a preference for warmer water (e.g., Gulf pipefish, Syngnathus scovelli, and Chain pipefish, S. louisiana). DiscussionThe results are consistent with the potential effects of climate change. However, the salinity of the bays in the study area generally exhibits an increasing trend from the northern to southern bays. The spatial salinity gradient has a substantial impact on species compositions, indicating that species distributions are influenced by multiple environmental conditions. This complexity makes our ability to accurately predict future species compositions under changing environmental conditions challenging.
A vendor-agnostic, PACS integrated, and DICOM-compatible software-server pipeline for testing segmentation algorithms within the clinical radiology workflow
Authors: Zhang Lei , LaBelle Wayne , Unberath Mathias , Chen Haomin , Hu Jiazhen , Li Guang , Dreizin David 
Published: October 2023

BackgroundReproducible approaches are needed to bring AI/ML for medical image analysis closer to the bedside. Investigators wishing to shadow test cross-sectional medical imaging segmentation algorithms on new studies in real-time will benefit from simple tools that integrate PACS with on-premises image processing, allowing visualization of DICOM-compatible segmentation results and volumetric data at the radiology workstation.PurposeIn this work, we develop and release a simple containerized and easily deployable pipeline for shadow testing of segmentation algorithms within the clinical workflow.MethodsOur end-to-end automated pipeline has two major components- 1. A router/listener and anonymizer and an OHIF web viewer backstopped by a DCM4CHEE DICOM query/retrieve archive deployed in the virtual infrastructure of our secure hospital intranet, and 2. An on-premises single GPU workstation host for DICOM/NIfTI conversion steps, and image processing. DICOM images are visualized in OHIF along with their segmentation masks and associated volumetry measurements (in mL) using DICOM SEG and structured report (SR) elements. Since nnU-net has emerged as a widely-used out-of-the-box method for training segmentation models with state-of-the-art performance, feasibility of our pipleine is demonstrated by recording clock times for a traumatic pelvic hematoma nnU-net model.ResultsMean total clock time from PACS send by user to completion of transfer to the DCM4CHEE query/retrieve archive was 5 min 32 s (± SD of 1 min 26 s). This compares favorably to the report turnaround times for whole-body CT exams, which often exceed 30 min, and illustrates feasibility in the clinical setting where quantitative results would be expected prior to report sign-off. Inference times accounted for most of the total clock time, ranging from 2 min 41 s to 8 min 27 s. All other virtual and on-premises host steps combined ranged from a minimum of 34 s to a maximum of 48 s.ConclusionThe software worked seamlessly with an existing PACS and could be used for deployment of DL models within the radiology workflow for prospective testing on newly scanned patients. Once configured, the pipeline is executed through one command using a single shell script. The code is made publicly available through an open-source license at “https://github.com/vastc/,” and includes a readme file providing pipeline config instructions for host names, series filter, other parameters, and citation instructions for this work.