bluuebunny/crossref_metadata_2025_split huggingface dataset:
Glucagon secretion and its association with glycaemic control and ketogenesis during sodium‐glucose cotransporter 2 inhibition by ipragliflozin in people with type 1 diabetes: Results from the multicentre, open‐label, prospective study
Authors: Nakamura Yuta , Horie Ichiro , Kitamura Tadahiro , Kusunoki Yoshiki , Nishida Kenro , Yamamoto Akane , Hirota Yushi , Fukui Tomoyasu , Maeda Yasutaka , Minami Masae , Matsui Takanori , Kawakami Atsushi , Abiru Norio 
Published: January 2024

AbstractAimClinical trials showed the efficacy of sodium‐glucose cotransporter 2 inhibitors for type 1 diabetes (T1D) by significant reductions in body weight and glycaemic variability, but elevated susceptibility to ketoacidosis via elevated glucagon secretion was a potential concern. The Suglat‐AID evaluated glucagon responses and its associations with glycaemic control and ketogenesis before and after T1D treatment with the sodium‐glucose cotransporter 2 inhibitor, ipragliflozin.MethodsAdults with T1D (n = 25) took 50‐mg open‐labelled ipragliflozin daily as adjunctive to insulin. Laboratory/clinical data including continuous glucose monitoring were collected until 12 weeks after the ipragliflozin initiation. The participants underwent a mixed‐meal tolerance test (MMTT) twice [before (first MMTT) and 12 weeks after ipragliflozin treatment (second MMTT)] to evaluate responses of glucose, C‐peptide, glucagon and β‐hydroxybutyrate.ResultsThe area under the curve from fasting (0 min) to 120 min (AUC0‐120min) of glucagon in second MMTT were significantly increased by 14% versus first MMTT. The fasting and postprandial β‐hydroxybutyrate levels were significantly elevated in second MMTT versus first MMTT. The positive correlation between postprandial glucagon secretion and glucose excursions observed in first MMTT disappeared in second MMTT, but a negative correlation between fasting glucagon and time below range (glucose, <3.9 mmol/L) appeared in second MMTT. The percentage changes in glucagon levels (fasting and AUC0‐120min) from baseline to 12 weeks were significantly correlated with those in β‐hydroxybutyrate levels.ConclusionsIpragliflozin treatment for T1D increased postprandial glucagon secretion, which did not exacerbate postprandial hyperglycaemia but might protect against hypoglycaemia, leading to reduced glycaemic variability. The increased glucagon secretion might accelerate ketogenesis when adequate insulin is not supplied.
Quantitative investigation on the deformation modes and cracking behavior during cyclic torsional loading of extruded pure Mg and Mg‐3Y alloy
Authors: He Liuyong , Wen Guilan , Zheng Jiang , Shi Rong , Xia Lihong , Li Tianjiao , Jiang Bin 
Published: January 2024

AbstractThis study explores the effect of adding 3 wt.% Y to pure magnesium (Mg) on its mechanical behavior under cyclic torsional loadings at room temperature. The research examines deformation and cracking modes in both pure Mg and Mg‐3Y samples. Deformation modes are monitored using quasi‐in‐situ EBSD observations coupled with slip trace analysis. The findings reveal that basal slip dominates the cyclic deformation throughout the fatigue life of the pure Mg sample, while both basal and pyramidal slip dominate the cyclic deformation in the Mg‐3Y sample. Intergranular cracking is the primary cracking mode for both samples under cyclic torsional loadings. Basal and pyramidal slip persistent slip band (PSB) cracking serves as a primary transgranular cracking mode in the pure Mg and Mg‐3Y samples, respectively. The study also investigates the underlying mechanism governing the activity of various deformation modes, cracking modes, and mechanical behavior.
Assessing the global vulnerability of dryland birds to heatwaves
Authors: Ding Chenchen , Newbold Tim , Ameca Eric I. 
Published: January 2024

AbstractAs global average surface temperature increases, extreme climatic events such as heatwaves are becoming more frequent and intense, which can drive biodiversity responses such as rapid population declines and/or shifts in species distributions and even local extirpations. However, the impacts of extreme climatic events are largely ignored in conservation plans. Birds are known to be susceptible to heatwaves, especially in dryland ecosystems. Understanding which birds are most vulnerable to heatwaves, and where these birds occur, can offer a scientific basis for adaptive management and conservation. We assessed the relative vulnerability of 1196 dryland bird species to heatwaves using a trait‐based approach. Among them, 888 bird species are estimated to be vulnerable to heatwaves (170 highly vulnerable, eight extremely vulnerable), of which ~91% are currently considered non‐threatened by the IUCN, which suggests that many species will likely become newly threatened with intensifying climate change. We identified the top three hotspot areas of heatwave‐vulnerable species in Australia (208 species), Southern Africa (125 species) and Eastern Africa (99 species). Populations of vulnerable species recorded in the Living Planet Database were found to be declining significantly faster than those of non‐vulnerable species (p = .048) after heatwaves occurred. In contrast, no significant difference in population trends between vulnerable and non‐vulnerable species was detected when no heatwave occurred (p = .34). This suggests that our vulnerability framework correctly identified vulnerable species and that heatwaves are already impacting the population trends of these species. Our findings will help prioritize heatwave‐vulnerable birds in dryland ecosystems in risk mitigation and adaptation management as the frequency of heatwaves accelerates in the coming decades.
Wildfire‐induced increases in photosynthesis in boreal forest ecosystems of North America
Authors: Kim Jinhyuk E. , Wang Jonathan A. , Li Yue , Czimczik Claudia I. , Randerson James T. 
Published: January 2024

AbstractObservations of the annual cycle of atmospheric CO2 in high northern latitudes provide evidence for an increase in terrestrial metabolism in Arctic tundra and boreal forest ecosystems. However, the mechanisms driving these changes are not yet fully understood. One proposed hypothesis is that ecological change from disturbance, such as wildfire, could increase the magnitude and change the phase of net ecosystem exchange through shifts in plant community composition. Yet, little quantitative work has evaluated this potential mechanism at a regional scale. Here we investigate how fire disturbance influences landscape‐level patterns of photosynthesis across western boreal North America. We use Alaska and Canadian large fire databases to identify the perimeters of wildfires, a Landsat‐derived land cover time series to characterize plant functional types (PFTs), and solar‐induced fluorescence (SIF) from the Orbiting Carbon Observatory‐2 (OCO‐2) as a proxy for photosynthesis. We analyze these datasets to characterize post‐fire changes in plant succession and photosynthetic activity using a space‐for‐time approach. We find that increases in herbaceous and sparse vegetation, shrub, and deciduous broadleaf forest PFTs during mid‐succession yield enhancements in SIF by 8–40% during June and July for 2‐ to 59‐year stands relative to pre‐fire controls. From the analysis of post‐fire land cover changes within individual ecoregions and modeling, we identify two mechanisms by which fires contribute to long‐term trends in SIF. First, increases in annual burning are shifting the stand age distribution, leading to increases in the abundance of shrubs and deciduous broadleaf forests that have considerably higher SIF during early‐ and mid‐summer. Second, fire appears to facilitate a long‐term shift from evergreen conifer to broadleaf deciduous forest in the Boreal Plain ecoregion. These findings suggest that increasing fire can contribute substantially to positive trends in seasonal CO2 exchange without a close coupling to long‐term increases in carbon storage.
Herbivore exclusion stabilizes alpine grassland biomass production across spatial scales
Authors: Zhu Juntao , Zhang Yangjian , Wu Jianshuang , Zhang Xianzhou , Yu Guirui , Shen Zhenxi , Yang Xian , He Yunlong , Jiang Lin , Hautier Yann 
Published: January 2024

AbstractThere is growing evidence that land‐use management practices such as livestock grazing can strongly impact the local diversity, functioning, and stability of grassland communities. However, whether these impacts depend on environmental condition and propagate to larger spatial scales remains unclear. Using an 8‐year grassland exclosure experiment conducted at nine sites in the Tibetan Plateau covering a large precipitation gradient, we found that herbivore exclusion increased the temporal stability of alpine grassland biomass production at both the local and larger (site) spatial scales. Higher local community stability was attributed to greater stability of dominant species, whereas higher stability at the larger scale was linked to higher spatial asynchrony of productivity among local communities. Additionally, sites with higher mean annual precipitation had lower dominant species stability and lower grassland stability at both the spatial scales considered. Our study provides novel evidence that livestock grazing can impair grassland stability across spatial scales and climatic gradients.
Colour characteristics, phenolic content and antioxidant activity of Spirulina platensis soaked in basil (Ocimum basilicum) leaves extract
Authors: Wijayanti Ima , Agustini Tri Winarni , Benjakul Soottawat 
Published: January 2024

SummarySpirulina platensis has been known as a super food with a high nutrition and biological activity. The limited addition of S. platensis into the food is due to its unpleasant odour. S. platensis was soaked in basil (Ocimum basilicum) leaves extract (BLE) to decrease the unpleasant odour and its antioxidant activities after soaking were unknown. This study aimed to evaluate the effect of ratio S. platensis with BLE on colour and sensory characteristics and to determine the total phenolic content (TPC) and antioxidant capacity of extracted S. platensis without and with BLE using different solvents. Spirulina platensis was soaked in BLE at a ratio of S. platensis and BLE of 1:3, 1:4, and 1:5 (w/v) for 15 min and then dried at 40°C for 10 h. The resultant powder was analysed for colour and sensory characteristics. The selected S. platensis with the best sensory characteristic was further extracted in water and ethanol and was compared with the S. platensis control (unsoaked in BLE). The ratio of S. platensis and BLE had a significant effect on the colour characteristics (P < 0.05). Spirulina platensis soaked in BLE at a ratio 1:4 had higher L* (35.98), a* (−6.57) and b* values (5.95) than the control. The ratio of S. platensis and BLE at 1:4 had a higher overall sensory value (4.16) than the control (2.35). The water extract of S. platensis unsoaked and soaked in BLE showed a higher TPC (1.178 and 1.667 mg GAE g−1 extract, respectively), DPPH, ABTS and metal chelating, but lower in FRAP compared with the ethanol extract. Spirulina platensis soaked in BLE which were extracted in water and ethanol had higher ORAC (63.27 and 56.33 mmol Teq g−1 extract, respectively) than the control. Spirulina platensis soaked in BLE increased its sensory value while maintaining the antioxidant capacity. Therefore, it can potentially be added in more quantities to various foods as functional foods.
Just‐in‐time scheduling problem with due windows and release dates for precast bridge girders
Authors: Liu Gang , Wang Hongwei , Xie Yong 
Published: January 2024

AbstractAs the prefabrication construction method plays an increasingly important role in the construction of cross‐sea bridges, coordinating the schedule between off‐site prefabrication and on‐site assembly becomes crucial and challenging. This paper studies a just‐in‐time single‐machine scheduling problem with due windows and release dates, which originates from the production and supply process of large segments of precast steel box girders in bridge construction. To solve this problem, we equivalently decompose it into the independent and same type of subproblems and formulate a mixed‐integer linear mathematical programming model. Furthermore, we propose a branch‐and‐bound algorithm with the initialization of a novel linear early and tardy dispatching rule with due windows to solve the problem exactly. The dispatching rule, based on the local dominance criteria with due windows, is designed and used to improve the upper bound. Moreover, a lower bound is obtained by further decomposing and relaxing the subproblems. Finally, the parameter of the dispatching rule is calibrated, and the best search strategy of the branch‐and‐bound algorithm is determined. The comprehensive computational experiments carried out show the efficiency and effectiveness of the proposed branch‐and‐bound algorithm.
Psychological effects of the COVID‐19 pandemic on primary healthcare professionals in Turkey: One year into the pandemic
Authors: Yücel Ummahan , Erkal Aksoy Yasemin , Yaşar Yetişmiş Habibe , Gök Çiğdem 
Published: January 2024

AbstractAim and ObjectivesThis study aimed to determine the psychological effects of the COVID‐19 pandemic on healthcare professionals working in primary care settings in the first year of the pandemic.BackgroundThe healthcare industry has faced an unprecedented burden in the COVID‐19 pandemic. Primary care professionals experienced the high level of psychological problems.Design and MethodsA total of 793 healthcare professionals from different regions of Turkey participated in this cross‐sectional study. The STROBE (Strengthening the reporting of observational studies in epidemiology) checklist was used in the study. Data were collected online.ResultsIt has been found that more than half of healthcare professionals experienced severe depression, three‐quarters experienced anxiety, and almost half experienced stress. It was also found that about half of the participants experienced a high degree of acute and chronic fatigue, and one‐fifth experienced low inter‐shift recovery.ConclusionThe effects of the COVID‐19 pandemic on the mental health of primary care professionals, especially nurses and midwives, are alarming. The problems that arise from the flawed healthcare delivery models and gender inequality, which worsen the usual psychological effects of the pandemic on primary care professionals, should be addressed urgently.Relevance to Clinical PracticePsychological support and rehabilitative services should be expanded to eliminate the short‐ and long‐term psychological effects of the pandemic on healthcare professionals.
Development and psychometric testing of the actualisation of evidence‐based nursing instrument
Authors: Parisod Heidi , Stolt Minna , Holopainen Arja , Siltanen Hannele , Pasanen Miko , Suhonen Riitta 
Published: January 2024

AbstractAimTo describe the development of the Actualisation of Evidence‐Based Nursing instrument targeted at nurses working in clinical practice (ActEBN‐nurses), meant for evaluating the actualisation of individual and organisational‐level support structures for evidence‐based nursing within social and healthcare organisations, and to test its validity and reliability.DesignCross‐sectional survey.MethodsThe FinYHKÄ model was used as the theoretical background of the instrument development and supplemented with the JBI Model of Evidence‐Based Healthcare, previous literature and items from a previous instrument, the Evidence‐Based Practice Process Assessment Scale, with permission of the copyright holders. After two rounds of expert panel and piloting, a national survey was conducted with the instrument in 2021. The target group consisted of nurses working in clinical practice. Psychometric testing included internal consistency (Omega, item analysis) confirmatory factor analysis and t‐test for comparison of two groups' differences (sensitivity).ResultsA new instrument, ActEBN‐nurses was developed, comprising two parts: Individual‐level (32 items, 5‐point Likert‐scale) and Organisational‐level support structures for evidence‐based nursing (37 items, 5‐point Likert‐scale). In total, 1289 nurses participated in the survey. The ActEBN‐nurses proved to have good internal consistency in both parts (Omega ω .931 and .966), structural validity and sensitivity based on the two educational levels within the sample. The structure of both parts was slightly modified, based on the CFA modification indices, considering the impact of the reverse worded items in part Individual and redundant items within both parts.ConclusionThe ActEBN‐nurses has promising psychometrics, and it can be used for evaluating individual and organisational‐level support structures for evidence‐based nursing within social and healthcare organisations.Implications for the profession and/or patient careEvaluation of the support structures within social and healthcare organisations is needed to recognise shortcomings in current structures and advance evidence‐based nursing across different contexts.Reporting MethodThe authors state that they have adhered to relevant EQUATOR guidelines: STROBE statement for cross‐sectional studies.Patient or Public ContributionNo patient or public contribution.
Survey of flea infestation in cats and dogs in Western Andalusia, Spain: Seasonality and other risk factors for flea infestation
Authors: Zurita Antonio , Trujillo Ignacio , García‐Sánchez Ángela María , Cutillas Cristina 
Published: January 2024

AbstractThis epidemiological survey aims to provide an update on the main flea species that parasitize domestic animals in the Western Andalusia assessing several ecological features that could be considered as possible risk factors for flea infestation. Over a 19‐month period (June 2021 to January 2023), we obtained a total of 802 flea samples from 182 dogs (Canis lupus familiaris, Carnivora: Canidae, Linnaeus, 1758) and 78 cats (Felis silvestris catus, Carnivora: Felidae, Schreber, 1775). For each parasitized host, an epidemiological survey was completed, including the following information: geographical origin, age, sex, rural or urban habitat, type of animal's lifestyle (domestic or non‐domestic), health status, cohabiting or not with other animals and the total number of collected fleas. The most common species was Ctenocephalides felis (Siphonaptera: Pulicidae) (Bouché, 1835) with a total of 713 specimens, which accounted for 89% of the total fleas. The second most abundant species was Pulex irritans (Siphonaptera: Pulicidae) (Linnaeus, 1758) with a total of 46 collected fleas (6% of the total). The remaining species identified were Archaeopsylla erinacei (Siphonaptera: Pulicidae) (Bouché, 1835) (25 specimens), Spilopsyllus cuniculi (Siphonaptera: Pulicidae) (Dale, 1878) (12 specimens) and Ctenocephalides canis (Siphonaptera: Pulicidae) (Curtis, 1826) (6 specimens), which accounted for 3%, 1% and 1%, respectively, of the total fleas collected. The months with the highest number of collected fleas were, in ascending order, May 2022, September 2021 and July 2021. Dogs had a greater diversity of flea species, and flea sex ratios were female biased in all identified species and among all studied hosts. Finally, we identified some potential host risk factors that promoted higher flea intensities, such as living in rural areas, or presenting other pathologies.
CsHLS1‐CsSCL28 module regulates compact plant architecture in cucumber
Authors: Wang Chunhua , Li Jie , Fang Kai , Yao Hongxin , Chai Xingwen , Du Yalin , Wang Junwei , Hao Ning , Cao Jiajian , Li Baohai , Wu Tao 
Published: January 2024

SummaryIncreased planting densities boost crop yields. A compact plant architecture facilitates dense planting. However, the mechanisms regulating compact plant architecture in cucurbits remain unclear. In this study, we identified a cucumber (Cucumis sativus) compact plant architecture (cpa1) mutant from an ethyl methane sulfonate (EMS)‐mutagenized library that exhibited distinctive phenotypic traits, including reduced leaf petiole angle and leaf size. The candidate mutation causes a premature stop codon in CsaV3_1G036420, which shares similarity to Arabidopsis HOOKLESS 1 (HLS1) encoding putative histone N‐acetyltransferase (HAT) protein and was named CsHLS1. Consistent with the mutant phenotype, CsHLS1 was predominantly expressed in leaf petiole bases and leaves. Constitutive overexpressing CsHLS1 in cpa1 restored the wild‐type plant architecture. Knockout of CsHLS1 resulted in reduces leaf petiole angle and leaf size and as well as decreased acetylation levels. Furthermore, CsHLS1 directly interacted with CsSCL28 and negatively regulated compact plant architecture in cucumber. Importantly, CsHLS1 knockout increased the photosynthesis rate and leaf nitrogen in cucumbers, thereby maintaining cucumber yield at normal density. Overall, our research provides valuable genetic breeding resource and gene target for creating a compact plant architecture for dense cucumber planting.
Parents’ use of digital technology for social connection during the COVID‐19 pandemic: A mixed‐methods study
Authors: Nowland Rebecca , McNally Lara , Gregory Peggy 
Published: January 2024

IntroductionThe COVID‐19 pandemic (2020–2021) resulted in isolation due to social distancing rules and lockdowns, during which technology was used to enable families and friends to maintain contact. Despite loneliness being high in parents, little is known about which parents are more likely to experience loneliness and strategies to support them.MethodThis mixed‐methods study examines which parents were lonely during the pandemic and how digital technologies were used to reduce loneliness and social isolation. Data were collected during the first UK lockdown from May to July 2020 via an online survey (N = 145) and follow‐up interviews (n = 13).ResultsLoneliness reported during lockdown was greater than retrospective reporting of loneliness for all respondents, but it was higher in single parents, those caring for children with specific needs, and those with lower household incomes before and during lockdown. Parents rapidly adapted to and experimented with using technology for social connection during the lockdown, which helped to reduce feelings of isolation and loneliness. Video calling was found to be useful for making connections and enhancing social presence, but parents also experienced anxieties and difficulties with its use. There were mixed views about technology use; some were keen to continue using technology for socializing after the lockdown ended, but for others, it was only a temporary measure.ConclusionAlthough technology was invaluable during the pandemic, it was not a panacea, and the way parents used it was influenced by their approach to technology and existing social behaviors and networks.