bluuebunny/crossref_metadata_2025_split huggingface dataset:
A narrative review on the role of genetics in children with acute recurrent pancreatitis and chronic pancreatitis
Authors: Yu Bo , Yu Yi , Wang Xinqiong , Xu Chundi , Xiao Yuan 
Published: October 2023

ABSTRACTThe incidence of pancreatitis in children has increased over the past two decades. With advances in molecular biological techniques and clinical research, genetic variations have emerged as a pivotal etiological factor in pediatric pancreatitis. This review aims to summarize recent clinical research advancements in understanding pediatric pancreatitis caused by various gene mutations. As of the year 2020, researchers had identified 12 genes implicated in the pathogenesis of pancreatitis. These genes primarily contributed to the development of pancreatitis through three mechanisms. Pancreatitis resulting from these gene mutations exhibits several distinct characteristics, including early onset, a heightened risk of developing pancreatic duct stones, rapid disease progression, and a significantly increased risk of pancreatic endocrine and exocrine dysfunction, as well as pancreatic cancer in the future. Genetic sequencing is recommended for children with pancreatitis based on six indications. The sequencing not only assists in the clinical diagnosis but also enhances our understanding of the pathophysiology of pancreatitis.
Study on tensile stress fluctuation of poly(butylene succinate) (PBS) and its bicrystalline block copolyesters (PBSEG)
Authors: Zhou Xiaoming , Wu Junwei , Yu Dongdong 
Published: October 2023

AbstractBased on the stress fluctuation during the tensile process of poly(butylene succinate) (PBS), the tensile behavior of biodegradable bicrystalline block copolyesters (PBSEG) synthesized using polycondensation of poly(ethylene glycol) (PEG) and poly(butylene succinate) (PBS) was further studied. The effects of tensile rate and temperature test conditions on the stress–strain behavior of bicrystalline block copolymer PBSEG were investigated by conducting tensile tests. The experimental results showed that when the mass content of polyethylene glycol in PBSEG was 60%, the material did not show obvious periodic stress fluctuation during the “cold drawing” stage of the stress–strain curve, but showed different and more complicated periodic curve changes. The stress fluctuation of PBSEG copolyester had the characteristics of small amplitude and short period. The elongation at break increased obviously, and the maximum elongation at break was more than 2000%. The analysis of morphology and structure showed that the surface morphology of PBSEG dumbbell bars did not show obvious alternating changes in structure, characterized by light and dark. Craze was the main cause of ductile fracture for PBS and PBSEG copolyesters. The tensile fracture of the two materials occurred in the stress fluctuation region.Highlights
Small‐amplitude and short‐period stress fluctuation for PBSEG copolyester.
There was no alternating light and dark on the surface of the PBSEG stretched spline.
Craze was the main cause of ductile fracture for PBS and PBSEG copolyesters.
Tensile fracture of the materials occurred in the stress fluctuation region.
Molecular insight into endosulfan degradation by Ese protein from Arthrobacter: Evidence‐based structural bioinformatics and quantum mechanical calculations
Authors: Andrade‐Collantes Ernesto , Landeros‐Rivera Bruno , Sixto‐López Yudibeth , Bello‐Rios Ciresthel , Contreras‐García Julia , Tiznado José Antonio Garzón , Pedroza‐Torres Abraham , Camacho‐Pérez Beni , Montaño Sarita 
Published: October 2023

AbstractEndosulfan is an organochlorine insecticide widely used for agricultural pest control. Many nations worldwide have restricted or completely banned it due to its extreme toxicity to fish and aquatic invertebrates. Arthrobacter sp. strain KW has the ability to degrade α, β endosulfan and its intermediate metabolite endosulfate; this degradation is associated with Ese protein, a two‐component flavin‐dependent monooxygenase (TC‐FDM). Employing in silico tools, we obtained the 3D model of Ese protein, and our results suggest that it belongs to the Luciferase Like Monooxygenase family (LLM). Docking studies showed that the residues V59, V315, D316, and T335 interact with α‐endosulfan. The residues: V59, T60, V315, D316, and T335 are implicated in the interacting site with β‐endosulfan, and the residues: H17, V315, D316, T335, N364, and Q363 participate in the interaction with endosulfate. Topological analysis of the electron density by means of the Quantum Theory of Atoms in Molecules (QTAIM) and the Non‐Covalent Interaction (NCI) index reveals that the Ese‐ligands complexes are formed mainly by dispersive forces, where Cl atoms have a predominant role. As Ese is a monooxygenase member, we predict the homodimer formation. However, enzymatic studies must be developed to investigate the Ese protein's enzymatic and catalytic activity.
State‐dependent dynamics of extramembrane domains in the β2‐adrenergic receptor
Authors: Nikte Siddhanta V. , Joshi Manali , Sengupta Durba 
Published: October 2023

AbstractG protein‐coupled receptors (GPCRs) are membrane‐bound signaling proteins that play an essential role in cellular signaling processes. Due to their intrinsic function of transmitting internal signals in response to external cues, these receptors are adapted to be highly dynamic in nature. The β2‐adrenergic receptor (β2AR) is a representative member of the family that has been extensively analyzed in terms of its structure and activation. Although the structure of the transmembrane domain has been characterized in the different functional states of the receptor, the conformational dynamics of the extramembrane domains, especially the intrinsically disordered regions are still emerging. In this study, we analyze the state‐dependent dynamics of extramembrane domains of β2AR using atomistic molecular dynamics simulations. We introduce a parameter, the residue excess dynamics that allows us to better quantify receptor dynamics. Using this measure, we show that the dynamics of the extramembrane domains are sensitive to the receptor state. Interestingly, the ligand‐bound intermediate state shows the maximal dynamics compared to either the active R*G or inactive R states. Ligand binding appears to be correlated with high residue excess dynamics that are dampened upon G protein coupling. The intracellular loop‐3 (ICL3) domain has a tendency to flip towards the membrane upon ligand binding, which could contribute to receptor “priming.” We highlight an important ICL1‐helix‐8 interplay that is broken in the ligand‐bound state but is retained in the active state. Overall, our study highlights the importance of characterizing the functional dynamics of the GPCR loop domains.
Effects of sumac supplementation on lipid profile: A systematic review and meta‐analysis of randomized controlled trials
Authors: Bahari Hossein , Taheri Shaghayegh , Namkhah Zahra , Barghchi Hanieh , Arzhang Pishva , Nattagh‐Eshtivani Elyas 
Published: October 2023

AbstractThis systematic review aimed to gather data on the effects of sumac supplementation on lipid profile. A systematic literature search was carried out using electronic databases (PubMed, Scopus, and Web of Science) up to March 2023 to identify eligible randomized controlled trials (RCTs) assessing the effects of sumac intake on lipid profile as an outcome. All participants enrolled in our study were adult individuals who consumed sumac, in various forms, as an intervention. The included articles were assessed using the Cochrane risk of bias assessment tool. Heterogeneity tests of the selected trials were performed using the I2 statistic. Random effects models were assessed based on the heterogeneity tests, and pooled data were determined as the weighted mean difference with a 95% confidence interval. In total, seven RCTs with a total sample size of 570 subjects were included. This study found a significant decrease in total cholesterol (TC) (weighted mean difference [WMD]: −10.01 mg/dL; 95% CI: −18.67, −1.34), triglyceride (TG) (WMD: −8.52 mg/dL; 95% CI: −14.79, −2.25), and low‐density lipoprotein (LDL)‐C levels (WMD: −9.25 mg/dL; 95% CI: −14.56, −3.93); Moreover, a significant increase was observed in high‐density lipoprotein (HDL)‐C concentration (WMD: 2.97 mg/dL; 95% CI: 0.75, 5.19). The reduction in TG and TC was greater in studies with a duration of ≥12 compared to <12 weeks. The increase in HDL‐C was greater in participants with an intervention duration of ≥12 compared to <12 weeks. Moreover, subgroup analysis based on the dose of sumac suggested a significant reduction in TC and LDL, specifically for doses below 3 g. Consumption of sumac significantly decreased serum TC, LDL‐C, and TG concentrations. This study suggested significantly positive effects on HDL‐C by intake of sumac. Longer interventions (>12 weeks) have a more favorable impact on TC, LDL‐C, and HDL‐C, while sumac doses below 3 g/day show greater effects on TC and LDL‐C. These findings underscore the potential of sumac supplementation as a valuable approach to lipid profile management.
The need for health system strengthening in the wake of natural disasters: Lessons from the 2023 Türkiye–Syria earthquake
Authors: Manirambona Emery , Obnial Joseph Christian , Musa Shuaibu Saidu , Miranda Adriana Viola , Haruna Usman Abubakar , Shomuyiwa Deborah Oluwaseun 
Published: October 2023

AbstractThe 2023 Türkiye–Syria earthquake was reported as the largest earthquake of Mw7.8, resulting in over 50,783 and 7259 deaths in Turkey and Syria, respectively. It has also damaged numerous residential buildings and other essential infrastructures, thus rendering more than 850,000 children and 356,000 pregnant women homeless, forcing them into displacement and its dire consequences, such as inadequate temporary shelters, a lack of access to safe drinking water, sanitation and hygiene (WASH), necessary for disease prevention, health promotion and maintenance. The disaster has disproportionately affected the Syrian refugee community in Turkey as it has fuelled disparities and discrimination, exacerbating the response to the disaster and forcing refugees to return to Syria due to dire living conditions. Minimizing the effects of the disaster on the communities is therefore essential. There is a need to strengthen health system resilience and emergency response to natural disasters to reduce and prevent the aftermath. Disaster preparedness plans should include regulations that ensure that local buildings and infrastructure are disaster‐resistant. Furthermore, it is vital to highlight the importance of funding and appropriate resource allocation for disaster risk reduction. These include improving plans and logistics for recovery efforts, adequate preparation of temporary shelters and evacuation centres and allocating necessities such as food and water. Investment in proper search and rescue response, a special workforce for response and the rebuilding of important infrastructure are crucial. Finally, response to disasters must be inclusive and prioritize vulnerable populations, such as children, the aged women and refugees.
Cut method for the multivariable Szeged‐like polynomial with application to hyaluronic acid
Authors: Tratnik Niko , Žigert Pleteršek Petra 
Published: October 2023

AbstractSzeged‐like topological indices are commonly studied distance‐based molecular descriptors. These indices, together with related graph polynomials, offer valuable tools for characterising graph structures. Two new polynomials, the SMP polynomial and the edge‐SMP polynomial, have been recently introduced and allow efficient computation of Szeged, Mostar, and PI indices (note that the abbreviation SMP comes from the names of these indices). In this paper, we develop the cut method to compute different versions of the SMP polynomial in a much more general way. In particular, the multivariable Szeged‐like polynomial is introduced for any strength‐weighted graph. Moreover, it is shown how it can be computed using strength‐weighted quotient graphs obtained by a partition of the edge set coarser than the ‐partition. The developed approach is demonstrated by calculating weighted‐plus SMP polynomial and related topological indices for hyaluronic acid.
There is still little or no evidence that systematic phonics is more effective than common alternative methods of reading instruction: Response to Brooks (2023)
Authors: Bowers Jeffrey S. 
Published: October 2023

AbstractBrooks (2023) rejects Bowers' (2020) conclusion that there is little or no evidence that systematic phonics is more effective than alternative teaching methods common in schools. He makes his case based on challenging my analysis of 4 or the 12 meta‐analyses reviewed in Bowers (2020). I show his criticisms are flawed and conclusions are unwarranted. I also briefly review the more recent PIRLS results that have been taken to support the claim that mandated synthetic systematic phonics has improved reading comprehension in England. This conclusion is also shown to be unjustified. I conclude there is still no reliable evidence that systematic phonics is best practice, that researchers should stop making strong claims based on the current evidence, and that the field needs to explore alternative approaches.
Risk of Developing Psychiatric Disease Among Adult Patients with Skin Disease: A 9-Year National Register Follow-Up Study in Norway
Authors: Balieva Flora , Abebe Dawit Shawel , Dalgard Florence J. , Lien Lars 
Published: October 2023

Abstract

Background
The existing association between skin disease and psychiatric comorbidity has gained attention during the last decades. Stress and mental illness can directly or indirectly affect skin disease, while dermatological conditions, known to impair life quality and mental well-being, can promote psychiatric conditions.

Objectives
The aim of this study was to assess the risk of developing psychiatric disease among adult dermatological patients over a period of time. The secondary objective was to see which psychiatric disorders developed most commonly, and which skin diseases posed the greatest risk for later mental health issues.

Methods
Adult dermatological patients were followed for 9 years (2008–2016) using the Norwegian Patient Registry, for both outpatient and inpatient specialist healthcare services. Dermatological patients were identified during the first 2 years and were then followed for psychiatric comorbidity prospectively for the next 7 years.
Cox regression models were applied to estimate the risks of psychiatric disorders among patients with skin diseases. Estimates were adjusted for age and gender differences. Hazard risk ratios (HR) with 95% CI are reported.

Results
Dermatological patients developed depressive disorders most frequently (4.1% vs. 2.3% in non-dermatological participants), followed by anxiety disorders (3.3% vs. 1.8%), and adjustment disorders (2.6% vs. 1.5%). Developing depressive disorders showed the highest HR among dermatological patients, HR (95% CI) = 2.5 (2.4–2.5), followed by disorders related to alcohol use, HR (95% CI) = 2.2 (2.1–2.5), and anxiety disorders, HR (95% CI) = 2.1 (2.1–2.2). Papulosquamous disorders were the skin conditions with the highest HR for developing a mental health condition, with depressive disorder having HR (95% CI) = 2.6 (2.5–2.9); anxiety disorders at HR (95% CI) = 2.9 (2.7–3.1); and disorders related to alcohol use at HR (95% CI) = 3.2 (2.8–3.6).

Conclusions
The study demonstrates that having a skin disease doubles to triples the risk of developing a psychiatric illness within 7 years, especially depression, anxiety, and alcohol use compared with the general population.
Physics, Structures, and Applications of Fluorite‐Structured Ferroelectric Tunnel Junctions
Authors: Hwang Junghyeon , Goh Youngin , Jeon Sanghun 
Published: October 2023

AbstractThe interest in ferroelectric tunnel junctions (FTJ) has been revitalized by the discovery of ferroelectricity in fluorite‐structured oxides such as HfO2 and ZrO2. In terms of thickness scaling, CMOS compatibility, and 3D integration, these fluorite‐structured FTJs provide a number of benefits over conventional perovskite‐based FTJs. Here, recent developments involving all FTJ devices with fluorite structures are examined. The transport mechanism of fluorite‐structured FTJs is explored and contrasted with perovskite‐based FTJs and other 2‐terminal resistive switching devices starting with the operation principle and essential parameters of the tunneling electroresistance effect. The applications of FTJs, such as neuromorphic devices, logic‐in‐memory, and physically unclonable function, are then discussed, along with several structural approaches to fluorite‐structure FTJs. Finally, the materials and device integration difficulties related to fluorite‐structure FTJ devices are reviewed. The purpose of this review is to outline the theories, physics, fabrication processes, applications, and current difficulties associated with fluorite‐structure FTJs while also describing potential future possibilities for optimization.
Ultra‐Stable ITO‐Free Organic Solar Cells and Modules Processed from Non‐Halogenated Solvents under Indoor Illumination
Authors: Müller David , Jiang Ershuai , Campos Guzmán Laura , Rivas Lázaro Paula , Baretzky Clemens , Bogati Shankar , Zimmermann Birger , Würfel Uli 
Published: October 2023

AbstractOrganic Photovoltaics (OPV) is a very promising technology to harvest artificial illumination and power smart devices of the Internet of Things (IoT). Efficiencies as high as 30.2% have been reported for OPVs under warm white light‐emitting diode (LED) light. This is due to the narrow spectrum of indoor light, which leads to an optimal bandgap of ≈1.9 eV. Under full sunlight, OPV devices often suffer from poor stability compared to the established inorganic PV technologies such as crystalline silicon. This study focuses on a potentially very cost‐effective Indium Tin Oxide (ITO) free cell stack with absorber materials processed from non‐halogenated solvents. These organic solar cells and modules with efficiencies up to 21% can already achieve remarkable stabilities under typical indoor illumination. Aging under 50,000 lux LED lighting leads to very little degradation after more than 11 000 h. This light dose corresponds to more than 110 years under 500 lux. For modules encapsulated with a flexible barrier, extrapolated lifetimes of more than 41 years are achieved. This shows that OPV is mature for the specific application under indoor illumination. Due to the large number of potential organic semiconducting materials, further efficiency increase can be expected.
Operando Spectroscopy Observation of Mo Clusters‐Ti3C2TX Catalyst/Support Interface's Dynamic Evolution in Hydrogen Evolution Reaction
Authors: Wu Peng Fei , Yang Yu Qi , Xi1 Hong Yan , Si Yang , Chu Yong Heng , Su Xiao Zhi , Yan Wen Sheng , You Ting Ting , Gao Yu Kun , Wang Yu , Chen Wen Xing , Huang Yu Ying , Yin Peng Gang 
Published: October 2023

AbstractThe interaction between catalyst and support plays an important role in electrocatalytic hydrogen evolution (HER), which may explain the improvement in performance by phase transition or structural remodeling. However, the intrinsic behavior of these catalysts (dynamic evolution of the interface under bias, structural/morphological transformation, stability) has not been clearly monitored, while the operando technology does well in capturing the dynamic changes in the reaction process in real time to determine the actual active site. In this paper, nitrogen‐doped molybdenum atom‐clusters on Ti3C2TX (MoACs/N‐Ti3C2TX) is used as a model catalyst to reveal the dynamic evolution of MoAcs on Ti3C2TX during the HER process. Operando X‐ray absorption structure (XAS) theoretical calculation and in situ Raman spectroscopy showed that the Mo cluster structure evolves to a 6‐coordinated monatomic Mo structure under working conditions, exposing more active sites and thus improving the catalytic performance. It shows excellent HER performance comparable to that of commercial Pt/C, including an overpotential of 60 mV at 10 mA cm−2, a small Tafel slope (56 mV dec−1), and high activity and durability. This study provides a unique perspective for investigating the evolution of species, interfacial migration mechanisms, and sources of activity‐enhancing compounds in the process of electroreduction.
Nanotube‐Like Electronic States in [5,5]‐C90 Fullertube Molecules.
Authors: Jover Óscar , Martín‐Jiménez Alberto , Franklin Hannah M. , Koenig Ryan M. , Martínez José I. , Martín Nazario , Lauwaet Koen , Miranda Rodolfo , Gallego José M. , Stevenson Steven , Otero Roberto 
Published: October 2023

AbstractFullertubes, that is, fullerenes consisting of a carbon nanotube moiety capped by hemifullerene ends, are emerging carbon nanomaterials whose properties show both fullerene and carbon nanotube (CNT) traits. Albeit it may be expected that their electronic states show a certain resemblance to those of the extended nanotube, such a correlation has not yet been found or described. Here it shows a scanning tunneling microscopy (STM) and spectroscopy (STS) characterization of the adsorption, self‐assembly, and electronic structure of 2D arrays of [5,5]‐C90 fullertube molecules on two different noble metal surfaces, Ag(111) and Au(111). The results demonstrate that the shape of the molecular orbitals of the adsorbed fullertubes corresponds closely to those expected for isolated species on the grounds of density functional theory calculations. Moreover, a comparison between the electronic density profiles in the bands of the extended [5,5]‐CNT and in the molecules reveals that some of the frontier orbitals of the fullertube molecules can be described as the result of the quantum confinement imposed by the hemifullerene caps to the delocalized band states in the extended CNT. The results thus provide a conceptual framework for the rational design of custom fullertube molecules and can potentially become a cornerstone in the understanding of these new carbon nanoforms.
Designing a bacterial cellulose‐based hydrogel incorporated with manganese sulfide and graphene oxide for green extraction of acrylamide in bread samples
Authors: Sereshti Hassan , Rezvani Fatemeh , Soltani Sara , Karami Faezeh , Nodeh Hamid Rashidi 
Published: October 2023

AbstractA novel nanocomposite based on bacterial cellulose (BC) modified by manganese sulfide (MnS) decorated graphene oxide (GO) was prepared. The hydrogel was characterized by Fourier transform infrared, scanning electron microscopy, energy‐dispersive X‐ray spectroscopy, and adsorption/desorption techniques. The sorbent was employed for determining acrylamide in bread samples using micro‐solid‐phase extraction coupled with high‐performance liquid chromatography. The extraction efficiency of prepared sorbent was 1.4‐fold higher than that of BC. The important extraction factors including elution conditions (acetonitrile 300 μL, 5 min), sorbent composition and mass (50 mg), adsorption time (7 min), sample solution pH (8), and salt effect (3% w/v) were considered for optimization of the method. The analytical merit was validated by assessing the preconcentration factor (178–225), limit of detection (1.56 μg/kg), limit of quantification (5.15 μg/kg), linearity (5.15–500 μg/kg), and determination coefficient (0.9845). The adsorption isotherms and kinetic studies demonstrated that the adsorption process followed the Langmuir model and pseudo‐second‐order kinetics. The relative recoveries and relative standard deviations were 84%–106% and 2.4%–9.2%, respectively. This paper is the first report on the fabrication and use of BC doped with MnS‐GO composite for extraction of acrylamide in typical commercial bread samples.