bluuebunny/crossref_metadata_2025_split huggingface dataset:
Adverse Events of Peripherally Administered Norepinephrine During Surgery: A Prospective Multicenter Study
Authors: Christensen Jens , Andersson Elisabeth , Sjöberg Fredric , Hellgren Elisabeth , Harbut Piotr , Harbut Joanna , Sjövall Fredrik , von Bruhn Gufler Christian , Mårtensson Johan , Rubenson Wahlin Rebecka , Joelsson-Alm Eva , Cronhjort Maria 
Published: January 2024

BACKGROUND:
Perioperative treatment of hypotension by intravenous administration of norepinephrine in a peripheral vein can lead to adverse events, for example, tissue necrosis. However, the incidence and severity of adverse events during perioperative administration are unknown.

METHODS:
This was a prospective observational study conducted at 3 Swedish hospitals from 2019 to 2022. A total of 1004 patients undergoing surgery, who met the criteria for perioperative peripheral norepinephrine administration, were included. The infusion site was inspected regularly. If swelling or paleness of skin was detected, the infusion site was changed to a different peripheral line. Systolic blood pressure and pulse frequency were monitored during the infusion time and defined as adverse events at >220 mm Hg and <40 beats•min–1. In case of adverse events, patients were observed for up to 48 hours. The primary outcome was prevalence of extravasation, defined as swelling around the infusion site. Secondary outcomes were all types of adverse events and associations between predefined clinical variables and risk of adverse events.

RESULTS:
We observed 2.3% (95% confidence interval [CI], 1.4%–3.2%) extravasation of infusion and 0.9% (95% CI, 0.4%–1.7%) bradycardia. No cases of tissue necrosis or severe hypertension were detected. All adverse events had dissipated spontaneously within 48 hours. Proximal catheter placement was associated with more adverse events.

CONCLUSIONS:
Extravasation of peripherally administrated norepinephrine in the perioperative period occurred at similar rates as in previous studies in critically ill patients. In our setting, where we regularly inspected the infusion site and shifted site in case of swelling or paleness of skin, we observed no case of severe adverse events. Given that severe adverse events were absent, the potential benefit of this preventive approach requires confirmation in a larger population.
Short-Term High-Intensity Rowing Ergometry Training Improves Rowing Performance Equally in Healthy Weight and Obese Adolescents
Authors: WALTERS GRACE , DRING KARAH J. , NEVILL BENJAMIN A. , COOPER SIMON B. , NEVILL ALAN M. , NEVILL MARY E. , MORRIS JOHN G. 
Published: January 2024

ABSTRACT

Purpose
Childhood obesity is a major health concern and physical activity is commonly proposed as an intervention strategy to combat the increasing prevalence of overweight and obesity in young people. The aim of this study was to examine the effect of high-intensity, supervised, rowing ergometer training on maximal and submaximal rowing performance in healthy weight and centrally obese adolescents (12–13 yr).

Methods
Participants were randomized to either 6 wk of supervised rowing ergometry, comprising of 2 sessions per week with each session comprising of 2 × 3-min bouts of high-intensity rowing ergometry (n = 57), or a control group who continued with their habitual activities (n = 45). At baseline and follow-up, rowing performance was assessed via a submaximal test and a 3-min maximal test.

Results
Six weeks of rowing ergometer training significantly improved maximal exercise performance; total distance rowed in a 3-min maximal effort improved by 19.7 m (2.7%) (time × group, P = 0.018) and produced a significant reduction in perceived effort in response to a set submaximal load (60 W) (time × group, P = 0.040). At baseline total distance rowed during the 3-min maximal test was significantly affected by body mass (main effect of body mass, P = 0.002), whereby a higher body mass was associated with enhanced rowing performance. However, the pattern of change over time was not different between healthy weight and centrally obese adolescents (time × group × waist centile, P = 0.577).

Conclusions
A 6-wk high-intensity rowing ergometry training intervention improved maximal rowing performance. This improvement was similar in healthy weight versus overweight and obese adolescents; yet overall overweight and obese adolescents had superior rowing performance compared to their healthy weight counterparts, suggesting that rowing may be an attractive exercise modality for interventions in overweight and obese young people.
Postconcussion Moderate to Vigorous Physical Activity Predicts Anxiety Severity among Adolescent Athletes
Authors: SMULLIGAN KATHERINE L. , WINGERSON MATHEW J. , MAGLIATO SAMANTHA N. , RADEMACHER JACOB G. , WILSON JULIE C. , HOWELL DAVID R. 
Published: January 2024

ABSTRACT

Purpose
This study aimed to examine how moderate-to-vigorous physical activity (MVPA) during concussion recovery influences self-reported anxiety symptoms at follow-up assessment. We hypothesized that more MVPA after concussion would be associated with lower anxiety rating at follow-up.

Methods
We performed a prospective study of participants aged 13–18 yr initially assessed within 14 d of diagnosed concussion. Participants rated concussion symptoms using the Post-Concussion Symptom Inventory and were provided a wrist-worn actigraphy device to track activity for 1 wk after assessment. At follow-up assessment, participants rated anxiety symptoms using the four-question Patient-Reported Outcomes Measurement Information System (PROMIS) anxiety subscale. Each question ranged from 1 (never) to 5 (almost always), with an overall score range of 4–20. For univariable analysis, we calculated correlation coefficients between MVPA and PROMIS anxiety subscale scores. We then created a multiple linear regression model with follow-up PROMIS anxiety subscale score as the outcome and MVPA, sex, initial symptom severity, and preconcussion anxiety as predictors.

Results
We enrolled and initially tested 55 participants, and 48 were included in the final analysis (age, 14.6±2.7 yr; 56% female; initial assessment, 7.3± 3.1 d; follow-up assessment, 42.0±29.7 d). We observed an inverse and low correlation between MVPA and follow-up PROMIS anxiety subscale T-scores (r = −0.30, P = 0.04). Multivariable regression results indicated that MVPA (β = −5.30; 95% confidence interval (CI), −10.58 to −0.01), initial Post-Concussion Symptom Inventory score (β = 0.11; 95% CI, 0.03 to 0.19), and preconcussion anxiety (β = 5.56; 95% CI, 0.12 to 11.0), but not sex (β = −2.60; 95% CI, −7.14, to 1.94), were associated with follow-up PROMIS anxiety subscale T-scores.

Conclusions
After adjusting for covariates, more MVPA early after concussion predicted lower PROMIS anxiety subscale scores at follow-up. Although initial concussion symptom severity and preconcussion anxiety were also associated with follow-up PROMIS anxiety subscale score, MVPA represents a modifiable factor that may contribute to lower anxiety symptoms.
Low Energy Availability Followed by Optimal Energy Availability Does Not Benefit Performance in Trained Females
Authors: OXFELDT MIKKEL , MARSI DANIEL , CHRISTENSEN PETER M. , ANDERSEN OLE EMIL , JOHANSEN FRANK TED , BANGSHAAB MAJ , RISIKESAN JEYANTHINI , JEPPESEN JAN S. , HELLSTEN YLVA , PHILLIPS STUART M. , MELIN ANNA K. , ØRTENBLAD NIELS , HANSEN METTE 
Published: January 2024

ABSTRACTPurposeShort periods of reduced energy availability are commonly undertaken by athletes to decrease body mass, possibly improve the power-to-mass ratio, and enhance physical performance. Our primary aim was to investigate the impact of 10 d of low energy availability (LEA) followed by 2 d of optimal energy availability (OEA) on physical performance parameters in trained females. Second, physiological markers at the whole-body and molecular level related to performance were evaluated.MethodsThirty young trained eumenorrheic females were matched in pairs based on training history and randomized to a 10-d intervention period of LEA (25 kcal·fat-free mass (FFM)−1·d−1) or OEA (50 kcal·FFM−1·d−1) along with supervised exercise training. Before the intervention, participants underwent a 5-d run-in period with OEA + supervised exercise training. After the LEA intervention, 2 d of recovery with OEA was completed. Participants underwent muscle biopsies, blood sampling, physical performance tests, body composition measurements, and resting metabolic rate measurements. A linear mixed model was used with group and time as fixed effects and subject as random effects.ResultsCompared with OEA, LEA resulted in reduced body mass, muscle glycogen content, repeated sprint ability, 4-min time-trial performance, and rate of force development of the knee extensors (absolute values;P< 0.05). Two days of recovery restored 4-min time-trial performance and partly restored repeated sprint ability, but performance remained inferior to the OEA group. When the performance data were expressed relative to body mass, LEA did not enhance performance.ConclusionsTen days of LEA resulted in impaired performance (absolute values), with concomitant reductions in muscle glycogen. Two days of recovery with OEA partially restored these impairments, although physical performance (absolute values) was still inferior to being in OEA. Our findings do not support the thesis that LEA giving rise to small reductions in body mass improves the power-to-mass ratio and thus increases physical performance.
The role of the gut microbiota in the pathogenesis and treatment of Alzheimer disease – review
Authors: Wojtuś Magda , Tomaszuk Sebastian , Wąsik Karolina 
Published: January 2024

Introduction and purpose:
Currently, the role of the gut microbiota in the pathogenesis of different diseases is being widely researched, the understanding of whether the dysbiosis of the gut flora demonstrates the significant role in Alzheimer disease (AD) is accentuated. The aim of this paper is to summarize the existing paper about the role of the gut microbiota - its diversity, stability and composition in this condition. The search was conducted using PubMed and Google Scholarship databases.
Brief description of the state of knowledge:
It is still uncertain if alteration in gut microbiome is a consequence of AD or its risk factor, but some findings suggest that the intestinal flora is able to influence the activity of the brain and lead to its dysfunctions. There is also the association between composition of the gut microbiome and AD. Results indicate that affected patients had less heterogeneity in their microbiome and the progression of AD led to alterations in the bacterial flora. Introducing modifications of the gut microbiota is considered as a therapeutic option for AD. Following personalized diet, probiotics, prebiotics and synbiotics administration or fecal microbiota transplantation (FMT) may be beneficial for affected patients.
Conclusions:
The subject of the role of the gut microbiota merits further research as foregoing results of conducted studies are pointing to its possibly meaningful role. Presently, still more data is needed as most of the research was collected on animal models and the analysis conducted on humans remains insufficient. We conclude that further studies are warranted in order to fully understand the pathophysiology of the disease and the possible usefulness of microbiome therapy.
The relative effects of diversity on collective learning in local collaborative networks in Belgium
Authors: Carlier Nadège , Aubin David , Moyson Stéphane 
Published: January 2024

Collaborative networks are horizontal settings of public governance that enhance interactions between a diversity of actors (for example, civil servants, companies or citizens). They can help cross-cutting public policies (for example, climate policies) to gain coherence and become more innovative. To do so, collective learning, defined as the broadened and mutual understanding of public issues arising out of repeated social interactions, is critical but not spontaneous. In particular, the diversity of participants creates learning opportunities that do not necessarily transform into concrete learning.
So, how does diversity lead to collective learning in collaborative networks? To address this research question, this article researched two collaborative networks within the city administration of Schaerbeek (Belgium). Based on semistructured interviews, mental models were used to assess collective learning, and social network analysis was performed to understand the structure of interactions between diverse members.
The findings show that the influence of diversity on collective learning was contingent on the collaborative network, but fostered by social interactions, with noticeable links between formal and informal interactions. From these findings, the article makes three scholarly contributions. First, it deepens our understanding of collective learning, with a focus on the development of shared understandings as a condition of consensus formation. Second, it builds on psychology and resource management research to assess collective learning through mental models, and provides a new approach to the measurement of policy learning. Third, it contributes to the debate on the implications of different inclusion levels and conditions for the results of collaborative governance and their transformation in policy innovations.
Factors associated with barriers to healthcare access among ever-married women of reproductive age in Bangladesh: Analysis from the 2017–2018 Bangladesh Demographic and Health Survey
Authors: Hinata Hitomi , Lwin Kaung Suu , Eguchi Akifumi , Ghaznavi Cyrus , Hashizume Masahiro , Nomura Shuhei 
Published: January 2024

Background
Globally, women experience healthcare inequalities, which may contribute to excessive mortality rates at various stages of their lives. Though Bangladesh has achieved excellent progress in providing healthcare, the country still has some critical challenges that need immediate attention. The objective of this study is to examine the association between social determinants and barriers to accessing healthcare among ever-married women aged 15–49 in Bangladesh.

Methods
The study was conducted among 20,127 women aged 15–49, using data from the 2017–2018 Bangladesh Demographic and Health Survey. Four barriers to healthcare were considered: whether women face problems with permission, obtaining money, distance, and companionship. The multivariable logistic regression analysis was used, with a broad array of independent variables (such as age, and educational level) to identify the determinants of barriers to healthcare access. The associations were expressed as adjusted odds ratios (AOR) with a 95% confidence interval (CI).

Results
More than two-thirds (66.3%) of women reported having at least one perceived barrier to accessing healthcare. Women with a higher level of education (AOR = 0.49, 95% CI: 0.41–0.57), owning a mobile telephone (AOR = 0.78, 95% CI: 0.73–0.84), and those in the richest wealth quintile (AOR = 0.45, 95% CI: 0.38–0.52) had lower odds of having barriers to accessing healthcare. In addition, widowed (AOR = 1.53, 95% CI: 1.26–1.84), divorced (AOR = 1.91, 95% CI:1.47–2.48), or separated (AOR = 1.98, 95% CI: 1.46–2.69) women had higher odds of having a money barrier to accessing healthcare, than married women.

Conclusions
This study shows that individual-, household-, and community-level factors are associated with barriers to healthcare accessibility. To improve the state of women’s health in Bangladesh, it is vital to consider these socio-economic factors and implement fundamental measures, such as supporting the national health policy, empowering women’s socio-economic situation, and spreading the flexible way of healthcare access.
Sociodemographic disparities in sedentary time among US youth vary by period of the day
Authors: Santiago-Rodríguez María Enid , Chen Jinsong , Pfeiffer Karin A. , Marquez David X. , Bustamante Eduardo Esteban 
Published: January 2024

Introduction
Studies have reported sex and race/ethnicity disparities in sedentary time (ST), but none have evaluated ST by well-defined periods of the weekday (before school, during school, afterschool, and evening) and weekend day (morning, afternoon, and evening). Comparing sex and race/ethnicity disparities in ST at different periods of a weekday and weekend day can deepen our understanding of disparities and inform intervention efforts. This study tests sex and race/ethnicity disparities in ST by period of day in a representative sample of US youth.

Methods
Youth (N = 2,972) from the 2003–2006 NHANES waves reported demographic variables and wore an accelerometer for 7 consecutive days to assess ST. Linear regressions were conducted to test relationships between sex and race/ethnicity and ST (min/hour) during each period of a weekday and weekend day. ST differences by sex and race/ethnicity were calculated to identify the periods of the day presenting the largest opportunity to reduce disparities.

Results
Females were more sedentary than males during school (p < 0∙0001), afterschool (p < 0∙0001), and weekday evenings (p < 0∙0001) after controlling for covariates. After controlling for covariates, race/ethnicity only was a significant predictor of ST during weekend mornings (p < 0∙0001). During school and afterschool emerged as the periods with the largest opportunities to reduce sex disparities in ST. Weekend mornings were identified as the largest opportunity to reduce race/ethnic disparities in ST.

Conclusions
Sex disparities in ST appear to be driven mostly by the during school period of the day, while race/ethnic disparities in ST seem to be driven by the weekend morning period. Future intervention work should consider these periods when aiming to reduce ST disparities in youth.
Association Between Adolescent Pregnancy and Stunting Incidence: A Scoping Review
Authors: Nafisah Khilda Durrotun , Astuti Andari Wuri 
Published: January 2024

Background: Stunting is a developmental disorder that occurs in children caused by malnutrition, frequent infections, and poor psychosocial simulation. Stunting can be influenced by some factors such as infection, exclusive breastfeeding, early initiation of breastfeeding, and adolescent pregnancy. This study aims to review the association between adolescent pregnancy and stunting incidence.Method: This scoping review used the PRISMA-ScR framework by searching for articles from relevant databases such as Pubmed, EBSCO, and Wiley. The article search obtained ten articles for further analysis. The article was analyzed based on the Joanna Briggs Institute (JBI). The keywords used were Teen Pregnancy* OR Adolescent Pregnancy* OR Teen Pregnancies* AND Nutritional Deficiency* OR Undernutrition* OR Growth Disorder* OR Stunting*. Besides, the researcher added a filter, namely articles published in the last five years (2018-2022), articles that are open access, and original research articles.Results: Based on the results of reviewing the ten articles, it can be concluded that adolescent pregnancy is significantly associated with stunting incidence in adolescents with low education levels and poor economic conditions leading to poor health awareness and nutritional status. Future studies are expected to further evaluate the relationship between adolescent pregnancy and stunting incidence
Plasma levels of CD36 and glutathione as biomarkers for ruptured intracranial aneurysm
Authors: Wang Hanbin , Wang Luxuan , Liu Yunmei , Men Weidong , Hao Wanjiao , Fang Chuan , Li Chunhui , Zhang Lijian 
Published: January 2024

Abstract
Evidence has proved that intracranial aneurysm (IA) formation and rupture might be closely related to inflammatory response and oxidative stress. Our objective was to evaluate the potential of CD36 and glutathione (GSH) as biomarkers for IA. In this study, the enzyme-linked immunosorbent assay was used to measure the plasma levels of CD36 and GSH in 30 IA patients and 30 healthy controls. Then, correlation analysis, receiver operating characteristic (ROC) curve, and logistic regression analysis were performed. The results showed that the plasma level of CD36 in IA patients was significantly higher than that in the control group (P < 0.0001), and plasma GSH was significantly lower compared with that in the control group (P < 0.0001). ROC analysis showed that CD36 and GSH had high sensitivity (90.0 and 96.6%) and specificity (96.6 and 86.6%) for IA diagnosis. The combined sensitivity and specificity achieved were 100 and 100%, respectively. The plasma levels of CD36 and GSH did not show a significant correlation with age, the Glasgow Coma Scale, Hunter–Hess score, aneurysm size, aneurysm height, aneurysm neck, and aspect ratio. The AUC of the logistic regression model based on CD36 and GSH was 0.505. Our results suggested that the combination of plasma CD36 and GSH could serve as potential biomarkers for IA rupture.
Investigating the association between dietary patterns and glycemic control among children and adolescents with T1DM
Authors: Tayyem Reema , Zakarneh Sara , Al-Jayyousi Ghadir Fakhri 
Published: January 2024

AbstractNutrition plays a critical role in managing diabetes, particularly in children with type 1 diabetes mellitus (T1DM). This study aimed to investigate the dietary patterns associated with glycemic control among Jordanian children and adolescents with T1DM. A total of 107 Jordanian children and adolescents with T1DM were enrolled (53 males and 54 females) in this cross-sectional study. Data were collected through face-to-face interviews using three valid and reliable questionnaires. The study revealed that only 25.7% of the participants had good glycemic control, while almost 51% had poor glycemic control. Overall, three dietary patterns were identified in this study: “High-Vegetables,” “Unhealthy,” and “High-Fruits.” The “High-Vegetables” dietary pattern showed a protective association in controlling glycated hemoglobin at the second and third tertiles (odds ratio, CI: 0.07 (0.005–0.826); 0.06 (0.005–0.741), respectively). The “High-Vegetables” dietary pattern showed a protective effect against poor glycemic control. Although the association between the “Unhealthy” and “High-Fruits” dietary patterns and poor glycemic control did not reach significance at the tertiles level, it is noteworthy that a significantP-trend of 0.018 and 0.012, respectively, was observed for both patterns. We encourage children and adolescents to incorporate an assortment of whole, unprocessed vegetables into their diet in appropriate amounts to help manage their glycemic control.
Are the UN Sustainable Development Goals a Valuable Platform for Advancing a Basic Income? A Critical Historical Studies Account
Authors: Smith-Carrier Tracy A. , Van Tuyl Rana 
Published: January 2024

Abstract
United Nations (UN) leaders suggest that the world is not on track to meet the Sustainable Development Goals (SDGs) by 2030. The purpose of this paper is to explore whether the SDGs provide a valuable platform to call for a basic income (BI) globally. Adopting a critical historical studies approach, the article traces the evolution of ‘development’, including the UN decades of development, the Millennium Development Goals, and the SDGs. It subsequently describes the structural adjustment and poverty reduction efforts by the World Bank and International Monetary Fund, and then outlines why the SDG framework may be helpful in advancing a BI. We argue that as climate-related disasters increase, a BI will be vital in providing a modicum of security in an increasingly unstable world. Calls for BI must be anchored to a broader change agenda that recognizes the causes of poverty and income inequality, and seeks their dismantling and redress.