bluuebunny/crossref_metadata_2025_split huggingface dataset:
Chromosome 10q24.32 Variants Associate With Brain Arterial Diameters in Diverse Populations: A Genome‐Wide Association Study
Authors: Liu Minghua , Khasiyev Farid , Sariya Sanjeev , Spagnolo‐Allende Antonio , Sanchez Danurys L , Andrews Howard , Yang Qiong , Beiser Alexa , Qiao Ye , Thomas Emy A , Romero Jose Rafael , Rundek Tatjana , Brickman Adam M , Manly Jennifer J , Elkind Mitchell SV , Seshadri Sudha , Chen Christopher , Hilal Saima , Wasserman Bruce A , Tosto Giuseppe , Fornage Myriam , Gutierrez Jose 
Published: December 2023

Background
Brain arterial diameters (BADs) are novel imaging biomarkers of cerebrovascular disease, cognitive decline, and dementia. Traditional vascular risk factors have been associated with BADs, but whether there may be genetic determinants of BADs is unknown.

Methods and Results

The authors studied 4150 participants from 6 geographically diverse population‐based cohorts (40% European, 14% African, 22% Hispanic, 24% Asian ancestries). Brain arterial diameters for 13 segments were measured and averaged to obtain a global measure of BADs as well as the posterior and anterior circulations. A genome‐wide association study revealed 14 variants at one locus associated with global BAD at genome‐wide significance (
P
<5×10
−8
) (top single‐nucleotide polymorphism, rs7921574; β=0.06 [
P
=1.54×10
−8
]). This locus mapped to an intron of
CNNM2
. A trans‐ancestry genome‐wide association study meta‐analysis identified 2 more loci at
NT5C2
(rs10748839;
P
=2.54×10
−8
) and
AS3MT
(rs10786721;
P
=4.97×10
−8
), associated with global BAD. In addition, 2 single‐nucleotide polymorphisms colocalized with expression of
CNNM2
(rs7897654; β=0.12 [
P
=6.17×10
−7
]) and
AL356608.1
(rs10786719; β=−0.17 [
P
=6.60×10
−6
]) in brain tissue. For the posterior BAD, 2 variants at one locus mapped to an intron of
TCF25
were identified (top single‐nucleotide polymorphism, rs35994878; β=0.11 [
P
=2.94×10
−8
]). For the anterior BAD, one locus at
ADAP1
was identified in trans‐ancestry genome‐wide association analysis (rs34217249;
P
=3.11×10
−8
).

Conclusions

The current study reveals 3 novel risk loci (
CNNM2
,
NT5C2
, and
AS3MT
) associated with BADs. These findings may help elucidate the mechanism by which BADs may influence cerebrovascular health.
The Essence of Consciousness Eludes Psychology as a Science of the Palpable
Authors: Giorgi Amedeo 
Published: December 2023

Abstract
Historians of psychology are aware that, at its beginning, psychology had a choice with respect to the type of science it was going to be. It could be a content type psychology using the experimental method as proposed by Wundt or a basic empirical psychology founded on acts of consciousness explicated through critical analyses and careful descriptions of psychological phenomena as proposed by Brentano. As noted by Boring, because content was palpable and acts seemed elusive, Wundt’s experimental psychology prevailed. But Watson believed that, as they were themselves still difficult to detect, the content of conscious processes were not sufficiently palpable. So, he advocated using behavior as the basis for experimental psychology. Yet palpability is essential for the experimental method, not for studying consciousness. Intentionality is the essence of consciousness, but it is not palpable, though detectable. In the teens and twenties of the 19th Century some German psychologists developed a type of bipartite psychology that included both acts and content, but their work remained isolated.
Tell el-Amarna, 2022
Authors: Stevens Anna , Dabbs Gretchen R. , Balestra Fabien , Tully Gemma , Schiødt Sofie , Rose Pamela , Clapham Alan J. , Docherty Paul , Garnett Anna , Bertram Miriam 
Published: December 2023

Fieldwork at Amarna in 2022 included excavation at the Great Aten Temple and the North Desert Cemetery, and the continuation of several post-excavation projects. Those post-excavation projects reported on here are the study of skeletal materials, pottery, plant and organic remains, and inscriptions from the North Desert Cemetery; pottery, plant and other organic remains from the North Cliffs Cemetery; and digital modelling of the North Desert Cemetery. A programme of community outreach in collaboration with the Amarna Visitor Centre also recommenced. [Formula: see text]
Serum Protein-Based Profiles for the Diagnostic Model of Alzheimer’s Disease
Authors: Yang Li , He Liang , Bu Zhibin , Xuan Cheng , Yu Caiyan , Wu Jiong 
Published: December 2023

Background Determining a non-invasive, serum-based diagnostic panel for early diagnosis of AD will play a significant role in the prevention and treatment of the disease. Methods We performed standardized clinical assessments and neuroimaging measurements in 45 patients with AD and an equal number of sex - and age-matched controls. 48 target peptides of 14 identified target proteins were quantitatively analyzed by PRM. Results 8 protein markers were screened, including SAA4, PPBP, PF4, APOA4, F10, CPB2, C1S and IGHM. An diagnosis panel including 8 proteins and demographic characteristics markers respectively was found to be the robust with a AUC of 92.3%. Conclusions Our study developed a new panel including protein and demographic characteristics that could be used to distinguish AD from control candidates.
Smoking and Depression Risk Reduction in a Primary Care Setting
Authors: Mahmood Naveen , Goldstein Shira , Thiele Alan , Trotchie Mark , des Bordes Jude 
Published: December 2023

Introduction: Smoking is associated with many diseases and is a target for primary preventive efforts in numerous morbidities. Studies show that smoking and depression may be associated. Never-smokers are at significantly lower risk than current and former smokers. Despite this observation, the effect of smoking on depression risk reduction has not been adequately explored. The purpose of this study was to explore the effect of smoking on depression risk reduction in adult patients seen in a primary care clinic at an academic medical center 6 months after they were identified as being at risk for depression. Findings may influence the direction and intensity of our smoking cessation endeavors in patients at risk of depression who smoke. Methods: We conducted an analytic cross-sectional study using electronic medical records of patients 18 years and older seen a primary care setting between January 1, 2019 and December 31, 2020. All participants included had an initial depression risk score (assessed by the 9-item Patient Health Questionnaire (PHQ-9)) of 5 or higher, information on smoking status and a PHQ-9 score at 6 months. We determined the percentage of patients with PHQ-9 score decrease of 5 or more at 6 months and used logistic regression to determine the association depression risk reduction (of 5 units or more) at 6 months and smoking, adjusting for demographic, clinical, and behavioral characteristics. Results: Number of patients included were 120, mean age was 55 (16), years, 88 (74%) were female, 68 (57%) were African American, and 31 (26%) were Caucasian. Fifty (44%) had a history of smoking and 31 (25.8%) had improvement (ie, a decrease of 5 units or more) in their PHQ-9 score at 6 months. Smoking was associated with decreased odds of improvement in depressive symptoms (Odds ratio = 0.32, 95% Confidence interval: 0.12-0.87). Conclusion: Risk of depression was more likely to persist in smokers than non-smokers at 6 months. Addressing smoking behavior in those with risk of depression may be beneficial.
Web-Based Nutrition and Physical Activity Education Intervention to Ameliorate Cardiometabolic Risks: A Single-Arm and Non-Randomized Feasibility Study
Authors: Ab Hamid Mohd Ramadan , Buhari Siti Sabariah , Md Noor Harrinni , Azizan Nurul ‘Ain , Md Nor Norazmir 
Published: December 2023

Objective: This study aimed to evaluate the feasibility of the D-PATH website to improve dietary and physical activity management for patients with cardiometabolic risk. Methods: A website called D-PATH was developed, consisting of 6 learning units for managing hypertension. A 4-week program was implemented, and a pre- and post-intervention assessment was conducted to measure acceptability and changes in knowledge, attitude and practice, dietary intake, physical activity, and anthropometric status. Results: The D-PATH website was acceptable in terms of understandability, actionability and cognitive load. Knowledge, attitude and practice, and physical activity levels were improved, but no changes were noted for dietary intake and blood pressure level. Conclusion: The D-PATH website was accepted and feasible for the intervention study. This study has shed light on using the website to promote behavioral change in patients with cardiometabolic risks.
Facilitators and barriers to implementation of a patient and staff reported measure for screening of palliative concerns of patients with heart failure: a qualitative analysis using the Consolidated Framework for Implementation Research
Authors: Neo Shirlyn Hui-Shan , Tan Jasmine Yun-Ting , Ng Elaine Swee-Ling , Yoon Sungwon 
Published: December 2023

Background: Screening patients with patient-reported outcome measures allows identification of palliative care concerns. The Integrated Palliative Care Outcome Scale (IPOS) was developed in the United Kingdom for this purpose. Tools developed in another setting might not be readily usable locally. We previously evaluated the validity and reliability of the IPOS in our cardiology setting. However, it remains uncertain what factors would influence the subsequent implementation of IPOS for routine screening of patients with advanced heart failure in future practice. Objectives: This study aimed to identify the factors that could affect the IPOS implementation for patients with advanced heart failure. Design: This was a qualitative study conducted at the National Heart Centre Singapore. Methods: Patients with advanced heart failure who participated in our previous IPOS validation study were purposively recruited for semi-structured interviews. Healthcare workers caring for these patients and involved in the testing of the IPOS tool were also invited for interviews. The interviews were analyzed thematically and mapped to the Consolidated Framework for Implementation Research (CFIR). Results: Our analysis identified six potential facilitators and six potential barriers to implementation across five major domains of the CFIR (intervention characteristics, inner setting, outer setting, individual characteristics, and process). Facilitators include: (i) perception of utility, (ii) perception of minimal complexity, (iii) perception of relatability, (iv) conducive culture, (v) dedicated resources, and (vi) advocates for implementation. Barriers include: (i) need for adaptation, (ii) mindsets/role strains, (iii) resource constraints, (iv) cultural concerns, (v) individual needs, and (vi) change process. Conclusion: Institutions could focus on cultivating appropriate perceptions and conducive cultures, providing dedicated resources for implementation and introducing facilitators to advocate for implementation. Adaptation of IPOS to suit workflows and individual needs, consideration of change processes, and systemic changes to alleviate cultural, resource, and staff role strains would improve IPOS uptake during actual implementation in clinical services. Trial registration: Not applicable.
Bacterial and Bacteriophage Consortia Are Associated with Protective Intestinal Immuno-Modulatory Metabolites in Allogeneic Stem Cell Transplantation Patients
Authors: Thiele Orberg Erik , Meedt Elisabeth , Hiergeist Andreas , Xue Jinling , Heinrich Paul , Ghimire Sakhila , Miltiadous Oriana , Lindner Sarah , Schwarz Alix , Janssen Klaus-Peter , Herhaus Peter , Verbeek Mareike , van den Brink Marcel R.M. , Weber Daniela , Edinger Matthias , Wolff Daniel , Kleigrewe Karin , Herr Wolfgang , Bassermann Florian , Gessner André , Deng Li , Holler Ernst , Poeck Hendrik 
Published: December 2023

The human microbiome is a predictor of clinical outcome in patients undergoing allogeneic hematopoietic stem cell transplantation (allo-SCT). Besides bacteria, fungi and viruses as well as intestinal microbiota-derived metabolites are involved. However, it is still unclear how dynamic shifts in these three kingdoms contribute to the production of intestinal metabolites, how metabolites are impacted by graft-versus-host disease (GvHD) or antibiotics and whether they are associated with clinical outcome.
We report the two-year follow-up of a prospective, observational, longitudinal cohort of allo-SCT patients (n=78) at two German transplantation centers that combined three-kingdom (bacteria, fungi, viruses) analysis of intestinal microbial communities with targeted metabolomics ( Figure 1). Using Multi-omics factor analysis (MOFA), we uncovered a functional microbiome signature of bacteria from the Lachnospiraceae and Oscillospiraceae families and their associated bacteriophages, which correlated with the production of immuno-modulatory metabolites (IMMs) including short-chain fatty acids (SCFAs), branched-chain fatty acids (BCFA), metabolites associated with induction of type-I IFN signaling (IIMs) and immuno-modulatory secondary bile acids ( Figure 2). We established an Immuno-modulatory Metabolite Risk Index (IMM-RI) consisting of five index IMMs, which was associated with improved survival, less transplant-related mortality and reduced relapse rate. Onset of gastrointestinal GvHD and exposure to antibiotics significantly impacted intestinal levels of protective IMMs.
Using whole shotgun metagenomic sequencing, we observed that in IMM-RI low-risk patients, sustained production of protective IMMs was associated with a high abundance of microbial SCFA biosynthesis pathways, specifically butyric acid via butyryl-CoA:acetate CoA-transferase (BCoAT). Through genome assembly from viral metagenomic sequencing data, we detected two distinct bacteriophages which encoded BCoAT as an auxiliary metabolic gene. They were more abundant in IMM-RI low-risk patients and positively correlated with intestinal butyric acid levels, suggesting that these bacteriophages may modulate bacterial metabolite biosynthesis.
Our study identifies a specific microbiome signature associated with protective IMMs that could improve fecal microbiota transplantation (FMT) donor selection and provides a rationale for the development of engineered metabolite-producing consortia and defined metabolite combination drugs as novel microbiome-based therapies for cancer patients.
Effect of a Crossover and Resistance Exercise Routine on IL-15 in Adults with Type B Acute Lymphoblastic Leukemia during the Induction Phase. Randomized Pilot Study
Authors: Gallardo-Rodríguez Adán Germán , Olarte Carrillo Irma , Martínez Tovar Adolfo , Cerón Maldonado Rafael , Castellanos Sinco Humberto Baldemar , Ramos Peñafiel Christian Omar 
Published: December 2023

Background: IL-15 is a proinflammatory myokine essential for activating NK cells and CD8+ T lymphocytes, and its overexpression has been associated with decreased survival in patients with Acute Lymphoblastic Leukemia (ALL). Physical exercise has been shown to be safe, feasible, and beneficial in hematological cancers. This requires the activation of muscles that secrete cytokines such as IL-15, causing immune mobilization and accumulating CD8 T cells. The objective was to compare the effect of two exercise strategies on IL-15 and survival prognosis in adult patients diagnosed with de novo ALL. Material and Methods: A blind randomized clinical study was carried out where twenty-three peripheral blood samples were obtained pre- and post-exercise from patients classified into three types of intervention: resistance exercise (GER), crossover exercise (GEC), and control group (GC). Ethical disclosure: All patients gave written informed consent for the study and data collection. This three-arm, prospective, randomized, blinded, open-label pilot study (ratio 1:1:1) was conducted in accordance with the Declaration of Helsinki. Results: The results showed that the changes in IL-15 levels during the intervention were not significant in any of the groups (GC p= 0.237, GER p= 0.866, and GEC p= 0.678). However, 78.26% of patients achieved remission at the end of induction, while only 21.73% experienced a relapse. There were no deaths during the study. Conclusions: Although IL-15 compliance levels in GER and GC were similar, GER patients had a better prognosis. It is suggested that resistance exercises may help improve survival prognosis and reduce early relapses in patients with ALL.
Keywords
Interleukin-15; exercise; Acute lymphoblastic leukemia; chemotherapy; body composition
Efficacy of Bortezomib Combined with Hyper-CVAD in Adults with Relapsed Acute Lymphoblastic Leukemia or Positive Measurable Residual Disease
Authors: Ramos Peñafiel Christian Omar , Pérez Sámano Daniela , Gallardo-Rodríguez Adán Germán , Olarte Carrillo Irma , Terreros Palacios Camila , Martínez Murillo Carlos , Barranco Lampón Gilberto Israel , Cabrera García Álvaro , Castellanos Sinco Humberto Baldemar , Martínez Tovar Adolfo 
Published: December 2023

Background: Despite the advances in treating adult Acute Lymphoblastic Leukemia (ALL), relapses are among the most significant challenges to improving the prognosis. One of the tools that can predict bone marrow relapse, according to its positivity, is Measurable Residual Disease (MRD). Unfortunately, due to the high cost, access to innovative therapies is limited, so chemotherapy remains the most common treatment option. The combination of Bortezomib with Hyper-CVAD has already shown efficacy in patients with Multiple Myeloma. However, in patients with ALL, it is not yet proven. Material and Methods: A prospective cohort was carried out in patients with ALL who presented an +MRD or relapse and received treatment based on the combination of Bortezomib and Hyper-CVAD in two reference centers in Mexico City. Results: 20 cases with positive MRD were analyzed; 60% (n=12) became negative after the combination, 30% (n=6) persisted with a positive result, and 10% (n=2) passed away. Of the 43 individuals with bone marrow relapse, 43.5% (n=10) achieved a second complete remission (2CR), 34.8% (n=6) were refractory, and 21.7% (n=5) passed away. To integrate a second complete remission, 20% (n=2) achieved it in &lt; 4 cycles, while 50% (n=5) required four cycles of treatment (2 cycles A and two cycles B), and 30% (n=3) required six cycles. Conclusion: The combination of Bortezomib with the increased Hyper-CVAD scheme showed better results in making MRD negative, suggesting that this combination can be incorporated into first-line strategies.
Keywords: Bortezomib; Chemotherapy; Acute Lymphoblastic Leukemia; Relapse; Measurable Residual Disease.
Risk of Cancer in Relatives of Patients with Myelodysplastic Neoplasia and Acute Leukemias
Authors: Nitschke Nikolaj Juul , Rostgaard Klaus , Hjalgrim Henrik , Andersen Mette Klarskov , Grønbæk Kirsten 
Published: December 2023

Background:
The risk of cancer among relatives of patients with either myelodysplastic neoplasia (MDS), acute myeloid leukemia (AML) or acute lymphoblastic leukemia (ALL) has not been thoroughly examined.
Methods:
We linked the Danish Civil Registration System with the Danish Cancer Registry, the Danish National Acute Leukemia Registry, and the Danish Myelodysplastic Syndrome Database to estimate the relative risk of cancer among relatives of patients with MDS/AML/ALL. We used standardized incidence ratios (SIRs), i.e., the ratio of observed to expected number of cancers among the relatives as a measure of relative risk.
Results:
We identified 13010 first-degree (FDR) and 22051 second-degree (SDR) relatives of 8386 patients with MDS/ALL/AML. Disregarding basal cell carcinoma (BCC), the relative risk for cancer overall was increased in both FDR (SIR=1.3; 95% confidence interval (CI) 1.1-1.4) and SDR (SIR=1.5; 95% CI 1.2-1.8). SIRs among FDRs were statistically significantly increased for malignant melanoma, BCC and for the combined groups of cancers of the male genital organs, urinary tract, and MDS/AML/ALL. Among SDRs, SIRs were statistically significantly increased for malignant melanoma, BCC, and the combined group of cancers in the digestive organs and peritoneum.
Conclusions:
We observed an increased risk of cancer among FDR and SDR of patients with MDS/AML/ALL.
Evaluation of Artificial Intelligence (AI) for Acute Graft-Versus-Host Disease(GVHD) Classification
Authors: Choi Yoonhee 
Published: December 2023

Introduction
Graft-Versus-Host Disease(GVHD) following hematopoietic stem cell transplant is a significant complication, causing a 10-30% mortality rate. Staging and grading are often performed by physicians in training, such as residents and fellows, and the assessments can be inconsistent between different physicians and clinical centers. This inconsistency may lead to confusion for both the medical team and the patients. This study evaluates the performance of an artificial intelligence (AI) tool in determining the grade of acute GVHD, exploring its potential role in the classification of GVHD.
Method
We conducted a performance assessment of Chat-GPT-3.5 and Chat-GPT-4 in grading acute GVHD. We constructed a dataset comprising simulated patients with acute GVHD grades 1-4. We then posed a question to both Chat-GPT-3.5 and Chat-GPT-4.0, asking for the severity of GVHD in each patient. The physicians' assessment was based on the modified Glucksberg criteria.
Result
Both Chat-GPT tools use the Glucksberg criteria as a reference source. Overall, Chat-GPT-4.0 demonstrated 75% concordance with physician assessment, whereas Chat-GPT-3.5 showed 62.5% concordance. When provided with numerical data, both tools successfully graded acute GVHD with 100% accuracy. However, when given subjective data, Chat-GPT-4.0 exhibited 50% concordance with physician assessment, whereas Chat-GPT-3.5 showed 25%. Although Chat-GPT was able to provide staging for each organ involvement, it struggled to estimate the volume of diarrhea based on the number of episodes. For instance, when asked about the grading of a patient experiencing more than 20 episodes of diarrhea per day, the system concluded that the patient had acute GVHD grade 4. This suggests that Chat-GPT-4.0 has difficulty accurately assessing the amount of diarrhea unless it's exceeding significant amount.
Chat-GPT-3.5 exhibited challenges in accurately quantifying the Body Surface Area (BSA). It was unable to assess the BSA if it was less than 25%. Moreover, if the rash involved more than two areas of the body, even when described with alternative language (e.g., ‘torso’, ‘entire torso‘), it would disproportionately inflated the BSA.
Conclusion
The above results demonstrate that both tools are insufficient for accurately determining the grading of acute GVHD when only subjective data is provided, primarily due to the incapacity of Chat-GPT-3.5 to assess the Body Surface Area (BSA) and Chat-GPT-4.0 to evaluate the volume of diarrhea. However, both tools displayed 100% accuracy when objective data was provided, with Chat-GPT-4.0 notably capable of accurately indicating the stages of organ involvement. Healthcare professionals should not solely rely on Chat-GPT for assessment, and it is advisable to instruct patients against utilizing Chat-GPT to evaluate their own acute GVHD.