bluuebunny/crossref_metadata_2025_split huggingface dataset:
De volta a Furtado via Kaldor e Thirlwall: as teorias heterodoxas de crescimento como suporte para a retomada do enfoque furtadiano da questão regional
Authors: De Lourenço André Luís Cabral , Bezerra Márcia Maria de Oliveira , Da Silva Marconi Gomes , Pereira William Eufrasio 
Published: October 2023

O artigo tem o objetivo de apresentar e comparar as teorias heterodoxas de crescimento para economias abertas de Thirlwall e Kaldor visando avaliar como estas podem servir de elemento de para a interpretação da literatura de economia regional heterodoxa brasileira. A hipótese deste trabalho é que a inexistência de autonomia à formalização de fronteiras internas entre as regiões de um país não constitui impedimento para que os efeitos de intercâmbio entre elas possam gera configurações características de restrições de balanço de pagamento, impondo limitações à expansão de suas economias e desencadeando neste processo mecanismos de polarização entre as suas taxas de crescimento. Conclui que a literatura em questão justifica restabelecer a perspectiva de Furtado como chave para a interpretação e tratamento dos problemas regionais no Brasil.
Diferenças de rendimento entre as regiões metropolitanas de Belo Horizonte e Salvador: uma discussão a partir da decomposição de Oaxaca-Blinder
Authors: Cirino Jader Fernandes , De Lima João Eustáquio 
Published: October 2023

O presente trabalho quantifica e explica a diferença do rendimento/hora do trabalho entre as Regiões Metropolitanas de Belo Horizonte e Salvador. A escolha dessas últimas deve-se ao interesse em verificar de que forma a diferença do dinamismo econômico entre as duas regiões estaria impactando o retorno auferido no mercado de trabalho. Nesse sentido, utiliza o procedimento de Oaxaca (1973) e Blinder (1973) para decompor os diferenciais de rendimento entre as regiões de interesse. Os resultados encontrados mostram que, conforme o esperado, os rendimentos/hora na Região Metropolitana de Belo Horizonte (RMBH) são, em média, superiores aos encontrados na Região Metropolitana de Salvador (RMS), resultado da maior concentração e aglomeração econômica da primeira região, quando comparada à segunda.
Uso residencial de energia solar para as capitais brasileiras: as vantagens da região Nordeste
Authors: Pereira Navarro Tarik Liladas Freire , Fernandes Elaine Aparecida 
Published: October 2023

A fim de identificar a possibilidade de expansão do uso da energia solar no País, o trabalho avaliou a viabilidade do uso residencial de sistemas fotovoltaicos nas capitais brasileiras por meio de uma comparação entre o custo da geração, que depende do nível de radiação solar, e as tarifas de energia das distribuidoras que atuam nessas cidades. Observou-se que a tecnologia fotovoltaica se mostrou viável para a maioria das capitais avaliadas, principalmente para as capitais da Região Nordeste, com destaque para Teresina. Apesar deste resultado positivo, ainda existem capitais como São Paulo, Rio de Janeiro dentre outras que não apresentaram viabilidade de implantação desse tipo de geração de energia. Assim, sugere-se a criação de incentivos na forma de crédito mais barato, melhores condições de financiamento e reduções tributárias, além do contínuo aperfeiçoamento do ambiente regulatório para a maior difusão desse tipo de tecnologia. Em adição, sugere-se que devam existir estímulos específicos para cada região, conforme suas peculiaridades. Por fim, verificou-se grandes desafios no uso de painéis fotovoltaicos no País, mas, o Brasil é extremamente rico no que se refere ao recurso solar. Este fato pode garantir a viabilidade econômica de sistemas fotovoltaicos para grande parte do território nacional.
Identification of mobile development issues using semantic topic modeling of Stack Overflow posts
Authors: Gurcan Fatih 
Published: October 2023

Background
Increasing demands for mobile apps and services have recently led to an intensification of mobile development activities. With the proliferation of mobile development, there has been a major transformation in the architectures, paradigms, knowledge domains and skills of traditional software systems towards mobile development. Therefore, mobile developers experience a wide spectrum of issues specific to development processes of mobile apps and services.

Methods
In this article, we conducted a semantic content analysis based on topic modeling using mobile-related questions on Stack Overflow, a popular Q&A site for developers. With the aim of providing an understanding of the issues and challenges faced by mobile developers, we used a semi-automated methodology based on latent Dirichlet allocation (LDA), a probabilistic and generative approach for topic modeling.

Results
Our findings revealed that mobile developers’ questions focused on 36 topics in six main categories, including “Development”, “UI settings”, “Tools”, “Data Management”, “Multimedia”, and “Mobile APIs”. Besides, we investigated the temporal trends of the discovered issues and their relationships with mobile technologies. Our findings also revealed which issues are the most popular and which issues are the most difficult for mobile development. The methodology and findings of this study have valuable implications for mobile development stakeholders including tool builders, developers, researchers, and educators.
Unveiling the Electrolyte Cations Dependent Kinetics on CoOOH‐Catalyzed Oxygen Evolution Reaction
Authors: Jia Hongnan , Yao Na , Yu Can , Cong Hengjiang , Luo Wei 
Published: October 2023

AbstractThe electrolyte cations‐dependent kinetics have been widely observed in many fields of electrocatalysis, however, the exact mechanism of the influence on catalytic performance is still a controversial topic of considerable discussion. Herein, combined with operando X‐ray diffraction (XRD) and high‐resolution transmission electron microscopy (HRTEM), we verify that the electrolyte cations could intercalate into the layer of pristine CoOOH catalyst during the oxygen evolution reaction (OER) process, while the bigger cations lead to enlarged interlayer spacing and increased OER activity, following the order Cs+>K+>Na+>Li+. X‐ray absorption spectroscopy (XAS), in situ Raman, in situ Ultraviolet‐visible (UV/Vis) spectroscopy, in situ XAS spectroscopy, cyclic voltammetry (CV), and theoretical calculations reveal that the intercalation of electrolyte cations efficiently modify the oxidation states of Co by enlarging the Co−O bonds, which in turn enhance the d‐band center of Co, optimize the adsorption strength of oxygen intermediates, facilitate the formation of OER active Co(IV) species, and reduce the energy barrier of the rate‐determing step (RDS), thereby enhancing the OER activity. This work not only provides an informative picture to understand the complicated dependence of OER kinetics on electrolyte cations, but also sheds light on understanding the mechanism of other electrolyte cation‐targeted electrocatalysis.
Non‐Covalently Stapled H+/Cl− Ion Channels Activatable by Visible Light for Targeted Anticancer Therapy
Authors: Zhong Qishuo , Cao Yin , Xie Xiaopan , Wu Yuhang , Chen Zhiqing , Zhang Qiuping , Jia Chunyan , Wu Zhen , Xin Pengyang , Yan Xiaosheng , Zeng Zhiping , Ren Changliang 
Published: October 2023

AbstractThe development of stimuli‐responsive artificial H+/Cl− ion channels, capable of specifically disturbing the intracellular ion homeostasis of cancer cells, presents an intriguing opportunity for achieving high selectivity in cancer therapy. Herein, we describe a novel family of non‐covalently stapled self‐assembled artificial channels activatable by biocompatible visible light at 442 nm, which enables the co‐transport of H+/Cl− across the membrane with H+/Cl− transport selectivity of 6.0. Upon photoirradiation of the caged C4F‐L for 10 min, 90 % of ion transport efficiency can be restored, giving rise to a 10.5‐fold enhancement in cytotoxicity against human colorectal cancer cells (IC50=8.5 μM). The mechanism underlying cancer cell death mediated by the H+/Cl− channels involves the activation of the caspase 9 apoptosis pathway as well as the scarcely reported disruption of the autophagic processes. In the absence of photoirradiation, C4F‐L exhibits minimal toxicity towards normal intestine cells, even at a concentration of 200 μM.
Charakterisierung von Klimadaten für die computergestützte Simulation
Authors: Worch Anatol , Ackermann Thomas 
Published: October 2023

AbstractDie computergestützte Simulation des gekoppelten Wärme‐ und Feuchtetransports ist ein zunehmend verwendetes Werkzeug des bauphysikalischen Nachweises. Die gewählten klimatischen Randbedingungen sind einer der grundlegenden Parameter, die das Ergebnis maßgeblich beeinflussen. Derzeit werden für die Vorgaben eines normativen Nachweises nach DIN 4108‐3 verschiedene Modelle zur Berücksichtigung des Innenklimas diskutiert. Insbesondere die Beobachtung höherer relativen Feuchten im Innenraum stellt die bisherige Berücksichtigung in Frage. Im Aufsatz werden verschiedene klimatische Aspekte diskutiert und eine neue Bemessungsgröße zur Charakterisierung eines maximalen potenziellen Kondensationsrisikos aufgrund der klimatischen Parameter definiert. Das langfristige Monitoring verschiedener Innenklimate an der Hochschule Bielefeld ermöglicht einen Abgleich der Modellansätze mit der realen Situation im Gebäude.
Interoceptive awareness and therapist characteristics
Authors: Ovalle Agustina , Fischer Candice , Dagnino Paula , Vaccarezza Stephanie 
Published: October 2023

AbstractBackgroundThe differences between therapists can have a huge impact on treatment outcome. This makes it crucial for us to understand who therapists are and how they relate to their patients.AimThis study evaluated different variables relating to the therapist, particularly therapeutic style, which is understood as the degree of variability in therapists' thinking and application of interventions in their clinical work. Furthermore, this study examined how therapists interpret and connect with their own bodies, as this connection plays a crucial role in shaping their emotional experiences, which are closely intertwined with the bodily sensations experienced during therapy. The aim of the study was to examine the relationship between interoceptive awareness and therapeutic style.MethodThe study was nonexperimental, and the methodology was quantitative with a correlational scope. Participants were therapists who answered a battery of questionnaires on the person of the therapist.ResultsBased on the analyses carried out, results showed that awareness of the internal state of the body is linked to the therapist's style. It was observed that those therapists who reported greater warmth towards and involvement with their patients had an increased awareness of the state of their body.DiscussionGiven these results, we can conclude that it is crucial to study the awareness of the state of therapists' bodies, as this contributes to the understanding of the therapist as a person and, therefore, of the therapeutic process.
Dialectical behaviour therapy for men and boys: A systematic review
Authors: Holah Samuel , Maguire Nick , Bennetts Alison 
Published: October 2023

AbstractBackgroundDialectical behaviour therapy (DBT) is a popular treatment that targets emotional dysregulation, a key feature associated with borderline personality disorder (BPD). The majority of available literature exploring the effectiveness of DBT is based on research concerning female samples. Therefore, the application and efficacy of DBT as a treatment intervention for men and boys remains unclear.MethodsMultiple research databases were searched using a systematic review process for articles that reported on the use of DBT with male samples across any outcome measure and included pre‐ and post‐treatment symptom scores.ResultsNineteen studies met the inclusion criteria. Studies indicated that the application of DBT to male samples varies. Vast differences were found in treatment length, use of DBT modes and population settings. Most studies identified some benefits of DBT; however, the sample sizes were small and there was large heterogeneity across the studies.ConclusionsThere is preliminary evidence supporting the use of DBT for males, specifically targeting anger and violence as well as emotional dysregulation and suicidality. Despite this, the limitations and heterogeneity from the current studies preclude the current review from drawing any definitive conclusions about the overall efficacy of the treatment in this population.
Optimization of Ketobenzothiazole‐Based Type II Transmembrane Serine Protease Inhibitors to Block H1N1 Influenza Virus Replication
Authors: Colombo Éloïc , Désilets Antoine , Hassanzadeh Malihe , Lemieux Gabriel , Marois Isabelle , Cliche Dominic , Delbrouck Julien A. , Murza Alexandre , Jean François , Marsault Eric , Richter Martin V. , Leduc Richard , Boudreault Pierre‐Luc 
Published: October 2023

AbstractHuman influenza viruses cause acute respiratory symptoms that can lead to death. Due to the emergence of antiviral drug‐resistant strains, there is an urgent requirement for novel antiviral agents and innovative therapeutic strategies. Using the peptidomimetic ketobenzothiazole protease inhibitor RQAR‐Kbt (IN‐1, aka N‐0100) as a starting point, we report how substituting P2 and P4 positions with natural and unnatural amino acids can modulate the inhibition potency toward matriptase, a prototypical type II transmembrane serine protease (TTSP) that acts as a priming protease for influenza viruses. We also introduced modifications of the peptidomimetics N‐terminal groups, leading to significant improvements (from μM to nM, 60 times more potent than IN‐1) in their ability to inhibit the replication of influenza H1N1 virus in the Calu‐3 cell line derived from human lungs. The selectivity towards other proteases has been evaluated and explained using molecular modeling with a crystal structure recently obtained by our group. By targeting host cell TTSPs as a therapeutic approach, it may be possible to overcome the high mutational rate of influenza viruses and consequently prevent potential drug resistance.
Phase 1/2 trial of avelumab combined with utomilumab (4‐1BB agonist), PF‐04518600 (OX40 agonist), or radiotherapy in patients with advanced gynecologic malignancies
Authors: Knisely Anne , Ahmed Jibran , Stephen Bettzy , Piha‐Paul Sarina A. , Karp Daniel , Zarifa Abdulrazzak , Fu Siqing , Hong David Sanghyun , Rodon Ahnert Jordi , Yap Timothy A. , Tsimberidou Apostolia M. , Alshawa Anas , Dumbrava Ecaterina E. , Yang Yali , Song Juhee , Meric‐Bernstam Funda , Jazaeri Amir A. , Naing Aung 
Published: October 2023

AbstractBackgroundImmune checkpoint blockade has shown mixed results in advanced/recurrent gynecologic malignancies. Efficacy may be improved through costimulation with OX40 and 4‐1BB agonists. The authors sought to evaluate the safety and efficacy of avelumab combined with utomilumab (a 4‐1BB agonist), PF‐04518600 (an OX40 agonist), and radiotherapy in patients with recurrent gynecologic malignancies.MethodsThe primary end point in this six‐arm, phase 1/2 trial was safety of the combination regimens. Secondary end points included the objective response rate (ORR) according to Response Evaluation Criteria in Solid Tumors and immune‐related Response Evaluation Criteria in Solid Tumors, the disease control rate (DCR), the duration of response, progression‐free survival, and overall survival.ResultsForty patients were included (35% with cervical cancer, 30% with endometrial cancer, and 35% with ovarian cancer). Most patients (n = 33; 83%) were enrolled in arms A–C (no radiation). Among 35 patients who were evaluable for efficacy, the ORR was 2.9%, and the DCR was 37.1%, with a median duration of stable disease of 5.4 months (interquartile range, 4.1–7.3 months). Patients with cervical cancer in arm A (avelumab and utomilumab; n = 9 evaluable patients) achieved an ORR of 11% and a DCR of 78%. The median progression‐free survival was 2.1 months (95% CI, 1.8–3.5 months), and overall survival was 9.4 months (95% CI, 5.6–11.9 months). No dose‐limiting toxicities or grade 3–5 immune‐related adverse events were observed.ConclusionsThe findings from this trial highlight that, in heavily pretreated patients with gynecologic cancer, even multidrug regimens targeting multiple immunologic pathways, although safe, did not produce significant responses. A DCR of 78% in patients with cervical cancer who received avelumab and utomilumab indicates that further research on this combination in select patients may be warranted.
Memory colors of familiar objects induce general color preference
Authors: Liao Songyang , Yoshizawa Tatsuya 
Published: October 2023

AbstractPrevious studies have offered multiple explanations for the causality of color preference but no consensus has been reached. In this study, we propose an alternative explanation that the memory colors of familiar objects, especially food colors of humans can induce color preferences. We conducted two experiments. In Experiment 1, the memory color experiment, we asked participants to rate the similarity between presented color samples and memory colors of five familiar fruits and vegetables in Japan; we then calculated the location of the colors in the CIELAB color space that looked most similar to the remembered objects using the bivariate Gaussian function. In Experiment 2, the color preference experiment, color variations were created based on the memory colors obtained from Experiment 1. A different group of participants rated their preference for each color variation, then we applied regression analysis to these ratings. We observed two types of regressions between preference ratings and distance to memory colors: (1) for colors from red to green that represent the food colors for primates, color preference increased when the color was closer to the memory colors of the fruits and vegetables found in Experiment 1; and (2) for blue and purple colors, colors were preferred when they became bluer. We suggest that the evolutionarily acquired mechanism of color preference derives crucial cues from our ecological environment. Therefore, the mechanism produces the same color preference trend among people who grow up in similar environments, for example, environments containing the same fruits.
Advances in hydrogen energy conversion of graphdiyne‐based materials
Authors: Zheng Xuchen , Xue Yurui , Chen Siao , Li Yuliang 
Published: October 2023

AbstractGraphdiyne (GDY), a new carbon allotrope containing sp and sp2‐hybridized carbon atoms, features the one‐atom‐thick two‐dimensional structure with many unique and promising characteristics, such as highly conjugated and extremely large π structures, abundant carbon chemical bonds, naturally distributed pores, inherent band gap, excellent chemical and mechanical stability, highly uneven distributed surface charges, and can be grown on the surface of arbitrary substrates. GDY has been one of the hottest frontiers in chemistry and material sciences and represents a new development trend and research direction in the development of carbon materials. Owing to the unique characteristics in chemical and electronic structures, GDY has shown great application potentials and prospects in many fields, including catalysis, energy, optoelectronics, life science, and intelligent device. In this review, the structures, synthetic methods, and fundamental properties of GDY are introduced. In particular, the recent advances of GDY and its formed aggregates in hydrogen energy conversion are summarized and discussed.
More than mesolectic: Characterizing the nutritional niche of Osmia cornifrons
Authors: Crone Makaylee K. , Boyle Natalie K. , Bresnahan Sean T. , Biddinger David J. , Richardson Rodney T. , Grozinger Christina M. 
Published: October 2023

AbstractCharacterizing the nutritional needs of wild bee species is an essential step to better understanding bee biology and providing suitable supplemental forage for at‐risk species. Here, we aim to characterize the nutritional needs of a model solitary bee species, Osmia cornifrons (Radoszkowski), by using dietary protein‐to‐lipid ratio (P:L ratio) as a proxy for nutritional niche and niche breadth. We first identified the mean target P:L ratio (~3.02:1) and P:L collection range (0.75–6.26:1) from pollen provisions collected across a variety of sites and time points. We then investigated the P:L tolerance range of larvae by rearing bees in vitro on a variety of diets. Multifloral and single‐source pollen diets with P:L ratios within the range of surveyed provisions did not always support larval development, indicating that other dietary components such as plant secondary compounds and micronutrients must also be considered in bee nutritional experiments. Finally, we used pollen metabarcoding to identify pollen from whole larval provisions to understand how much pollen bees used from plants outside of their host plant families to meet their nutritional needs, as well as pollen from individual forager bouts, to observe if bees maintained strict floral constancy or visited multiple plant genera per foraging bout. Whole larval provision surveys revealed a surprising range of host plant pollen use, ranging from ~5% to 70% of host plant pollen per provision. Samples from individual foraging trips contained pollen from multiple genera, suggesting that bees are using some form of foraging decision making. Overall, these results suggest that O. cornifrons have a wide nutritional niche breadth, but while pollen P:L ratio tolerance is broad, a tolerable P:L ratio alone is not enough to create a quality diet for O. cornifrons, and the plant species that make up these diets must also be carefully considered.
MicroRNA‐30d and ‐483‐3p for bi‐ventricular remodelling and miR‐126‐3p for pulmonary hypertension in advanced heart failure
Authors: Gallo Alessia , Agnese Valentina , Sciacca Sergio , Scardulla Cesare , Cipriani Manlio , Pilato Michele , Oh Jae K. , Pasta Salvatore , Maalouf Joseph , Conaldi Pier Giulio , Bellavia Diego 
Published: October 2023

AbstractAimsMicroRNAs play a role in pathogenic mechanisms leading to heart failure. We measured a panel of 754 miRNAs in the myocardial tissue and in the serum of patients with heart failure with reduced ejection fraction due to dilatative idiopathic cardiomyopathy (DCM, N = 10) or ischaemic cardiomyopathy (N = 3), referred to left ventricular assist device implant. We aim to identify circulating miRNAs with high tissue co‐expression, significantly associated to echocardiographic and haemodynamic measures.Methods and resultsWe have measured a panel of 754 miRNAs in the myocardial tissue [left ventricular (LV) apex] and in the serum obtained at the same time in a well selected study population of end‐stage heart failure with reduced ejection fraction due to either DCM or ischaemic cardiomyopathy, referred to continuous flow left ventricular assist device implant. We observed moderate agreement for miR‐30d, miR‐126‐3p, and miR‐483‐3p. MiR‐30d was correlated to LV systolic as well as diastolic volumes (r = 0.78, P = 0.001 and r = 0.80, P = 0.005, respectively), while miR‐126‐3p was associated to mPAP and PCWP (r = −0.79, P = 0.007 and r = −0.80, P = 0.005, respectively). Finally, serum miR‐483‐3p had an association with right ventricular end diastolic diameter (r = −0.73, P = 0.02) and central venous pressure (CVP) (r − 0.68 p 0.03).ConclusionsIn patients with DCM, few miRNAs are co‐expressed in serum and tissue: They are related to LV remodelling (miR‐30d), post‐capillary pulmonary artery pressure (miR‐126‐3p), and right ventricular remodelling/filling pressures (miR‐483‐3p). Further studies are needed to confirm their role in diagnosis, prognosis or as therapeutic targets in heart failure with reduced ejection fraction.