bluuebunny/crossref_metadata_2025_split huggingface dataset:
A community health-coaching referral program following discharge from treatment for chronic low back pain – a qualitative study of the patient’s perspective
Authors: Roberts Katharine , Baysari Melissa , Ho Emma , Beckenkamp Paula , Tian Ye , Jennings Matthew , Amorim Anita , Maka Katherine , Morton Rachael , Ceprnja Dragana , Halliday Mark , Ferreira Manuela , Ferreira Paulo 
Published: January 2024

Abstract

Background:
Global policy and guidelines for low back pain (LBP) management promote physical activity and self-management and yet adherence is poor and a decline in outcomes is common following discharge from treatment. Health coaching has been found to be effective at improving exercise adherence, self-efficacy, and social support in individuals with chronic conditions, and may be an acceptable, cost-effective way to support people in the community following discharge from treatment for LBP.
Aim:
This qualitative study aimed to understand the aspects of a community over-the-phone health-coaching program, that were liked and disliked by patients as well as their perceived outcomes of the service after being discharged from LBP treatment.
Methods:
A purposive sampling approach was used to recruit 12 participants with chronic LBP, from a large randomised controlled trial, who were randomly allocated to receive a health coaching program from the Get Healthy Service® in Australia. Semi structured interviews were conducted, and a general inductive content analysis approach was taken to create a framework from the data.
Results:
Participants discussed positive and negative aspects of the health coaching that they found to be empowering and confidence building or disappointing and frustrating. The main themes uncovered from the interviews included the importance of the health coach, the value of goal setting, the quality of the advice received, the benefits of feeling supported, the format of the coaching service, and LBP specific knowledge. The participants reported the health coach and the coaching relationship to be the primary factor that influenced the program outcomes and the qualities of the coaching relationship they valued most were connection, communication, care, and competence.
Clinical Implications:
In an environment where self-management and self-care are becoming increasingly important, understanding the patient’s experience as part of a coaching program is likely to lead to improved quality of health coaching care, more tailored service delivery and potentially more effective and cost-effective community-based care for individuals with chronic LBP in the community after being discharged from treatment.
Trial Registration:
The GBTH trial was prospectively registered with the Australian New Zealand Clinical Trials Registry (ACTRN12620000889954) on 10/9/2020. Ethical approval was prospectively granted by the Western Sydney Local Health District Human Research and Ethics Committee (2020/ETH00115). Written informed consent was obtained from all participants. The relevant sponsor has reviewed the study protocol and consent form.
Genome-wide identification of ATG genes and their expression profiles under biotic and abiotic stresses in Fenneropenaeus chinensis
Authors: Guan Chenhui , Li Yalun , Wang Qiong , Wang Jiajia , Tian Caijuan , He Yuying , Li Zhaoxia 
Published: January 2024

Abstract

Background
Autophagy is a conserved catabolic process in eukaryotes that contributes to cell survival in response to multiple stresses and is important for organism fitness. Extensive research has shown that autophagy plays a pivotal role in both viral infection and replication processes. Despite the increasing research dedicated to autophagy, investigations into shrimp autophagy are relatively scarce.
Results
Based on three different methods, a total of 20 members of the ATGs were identified from F. chinensis, all of which contained an autophagy domain. These genes were divided into 18 subfamilies based on their different C-terminal domains, and were found to be located on 16 chromosomes. Quantitative real-time PCR (qRT-PCR) results showed that ATG genes were extensively distributed in all the tested tissues, with the highest expression levels were detected in muscle and eyestalk. To clarify the comprehensive roles of ATG genes upon biotic and abiotic stresses, we examined their expression patterns. The expression levels of multiple ATGs showed an initial increase followed by a decrease, with the highest expression levels observed at 6 h and/or 24 h after WSSV injection. The expression levels of three genes (ATG1, ATG3, and ATG4B) gradually increased until 60 h after injection. Under low-salt conditions, 12 ATG genes were significantly induced, and their transcription abundance peaked at 96 h after treatment.
Conclusions
These results suggested that ATG genes may have significant roles in responding to various environmental stressors. Overall, this study provides a thorough characterization and expression analysis of ATG genes in F. chinensis, laying a strong foundation for further functional studies and promising potential in innate immunity.
A virtual patient in interpretation of massive pleural effusion impact on hemidiaphragm work and an insignificant influence on blood oxygenation
Authors: Stecka Anna Małgorzata , Grabczak Elżbieta Magdalena , Michnikowski Marcin , Zielińska-Krawczyk Monika , Krenke Rafał , Gólczewski Tomasz 
Published: January 2024

Abstract

Computer modeling, particularly in the form of virtual patients, can be a useful tool for explaining complex phenomena associated with medical procedures. Based on interesting phenomena observed in 8 living patients undergoing large-volume therapeutic thoracentesis (TT) with pleural pressure (Ppl), transcutaneous oxygen and carbon dioxide pressures, and spirometric measurements, we formulated four questions regarding the impact of pleural effusion (PE) and TT on hemidiaphragm function and blood oxygenation. To answer these questions, we simulated right-sided PE in a virtual patient and studied changes in Ppl and lung volume during the respiratory cycle (exemplified by P-V loops, where P is Ppl in the ipsilateral hemithorax and V is the volume of both lungs), alveolar O2 (PAO2) and CO2 partial pressures and airflows in the main bronchi. The simulations suggest that: (a) the mediastinum compliance has a particular meaning for the work of both hemidiaphragms and explaining the 8-shape of P-V loops in hemidiaphragm inversion; (b) PAO2 is higher than normal before TT due to decreased ratio of the tidal volume to the volume of processed air at the end of expiration; and (c) in some patients, the Ppl amplitude related to breathing can be significantly greater before TT than later on.
Assessment of landfill groundwater quality and regulating factors: a case study of northern Sichuan
Authors: Liu Guo , Zhang Wen , Tu Yujiao , Zhu Mingtan , He Changlong , Li Yaling , Chen Jiajing , Chen Yudi 
Published: January 2024

Abstract
A total of 31 groundwater samples were obtained and analyzed in this research endeavor from a conventional rural landfill situated in the red-layer region of northern Sichuan. The Chemical characteristics, controlling factors and hydrogeochemical processes of the groundwater in the study area were elucidated through the application of multivariate statistical analysis and ionic ratio analysis. To predict the spreading range and concentration of the contaminants in the landfill, a groundwater flow model and a solute transport model were constructed using groundwater numerical simulation software. The Piper diagram revealed that the majority of the groundwater exhibited a chemical composition of HCO3-Na and SO4·Cl-Na, which is denoting neutral or weakly alkaline groundwater and belonged to the soft-fresh and hard-brackish water types, respectively. The concentrations of NH4-N in groundwater varied from 0.025 to 17.3 mg/L, with 51.61% of samples surpassing the limit of 0.5 mg/L established by the World Health Organization for drinking water. The groundwater chemistry in the studied area was primarily affected by cation exchange, human activities, and the weathering of carbonate rocks, according to the Gibbs plot, ionic ratio analysis, and SI calculations. According to the calculated weighted water quality index (EWQI), the majority of the groundwater quality indicators in the study area were classified as poor or very poor, with NH4-N concentration being the primary determinant. Numerical simulation results showed that the diffusion area of the NH4-N pollution plume in the horizontal plane along the direction of groundwater flow was 5618 m2, 10142 m2, and 11695 m2 for 1, 5, and 10 years of waste leachate leakage, respectively. In conclusion, the findings of this research offer a scientific basis for the remediation of groundwater attributable to the landfill situated in the red-layer region of northern Sichuan.
Induction of Ageing and Apoptosis by Sucrose in Penicillium aurantiogriseum
Authors: Bouhoudan Assia , Chidi Fatima , Khaddor Mustapha 
Published: January 2024

Abstract
This work aims to study the physiological and metabolic responses of P. aurantiogriseum to sucrose-induced stress. Comparative analyses on intra-species (within strains of P. aurantiogriseum), and interspecies (between P. aurantiogriseum and P. camembertii) were conducted to assess the effect of carbon stress on aging phenomena and toxigenesis. Our results revealed a correlation between sucrose concentration and ageing signs. At a sucrose concentration of 500 g/L, the ageing signs of P. aurantiogriseum began to fade, allowing its normal characteristics to resurface. This transformation is believed to be a response to the sucrose and the cells that cannot adapt undergo apoptosis, leaving only the normal cells to thrive. Terrestric acid production was observed during the ageing process and continued even after returning to a normal physiological state, albeit at a reduced level.
The Wired and Wireless Hybrid Access Network Based on Optimized Self-Homodyne and Heterodyne technology
Authors: Shi Xiangyuan , Ji Wei , Liu Pengcheng , Yin Peng 
Published: January 2024

Abstract
A novel wired and wireless hybrid access system based on self-homodyne and heterodyne technology is presented in this paper. With the 16 Quadrature Amplitude Modulation(16QAM) and optimized self-homodyne mechanism, the system achieves 224Gbit/s wired access. Through optical heterodyne technology, the 30GHz wireless covering is implemented. The performance of the system is further improved by using the Pre-Compensation module and Post-Compensation module. Self-homodyne system improves the Optical Signal Noise Ratio(OSNR) threshold by 1.7 dB compared to the conventional coherent system, while reducing the system device requirements. The adoption of the Pre-Compensation module will save 1.7dB of OSNR tolerance even further. DSP modules of low computational complexity suitable for self-homodyne system and heterodyne system are redesigned. Quasi-coherent technology provides better transmission performance compared to conventional Radio over Fiber (RoF) technology, but is less complex than coherent systems .
Influence of Multi-Walled Carbon Nanotube Modified Carbon Fiber Material Prepared by Electrophoretic Deposition on the Properties of Chlorobutyl Rubber/Natural Rubber Composite Materials
Authors: Jing Yuan , Zhao Meng , Zhang Su , Lin Guangyi , Xiao Hongmei , Zhu Limeng 
Published: January 2024

Abstract
Electrophoretic deposition (EPD) is a direct current field that enables the deposition of carbon nanotube (CNT) suspensions onto the surface of carbon fibers (CFs). In this study, CFs were modified using EPD to attach multi-walled carbon nanotubes (MWCNTs) onto their surface. The CF@MWCNTs hybrid material was then applied to chlorobutyl rubber/natural rubber (CR/NR) composite materials. The microstructure of the materials was characterized using scanning electron microscopy (SEM). Mechanical property tests were conducted on the composite materials, and the results showed significant improvements compared to composites without the reinforcing agent. The tensile strength, hardness, and thermal conductivity of the composite materials were enhanced, with the thermal conductivity increasing by 33.7%. Additionally, the curing time was reduced by 11.37%, improving the curing efficiency. This provides a method for designing functional polymer composite materials.
Mortality rates in Norwegian HEMS – a retrospective analysis from Central Norway
Authors: Wekre Stian Lande , Uleberg Oddvar , Næss Lars Eide , Haugland Helge 
Published: January 2024

Abstract
Background: Helicopter Emergency Medical Services (HEMS) provide rapid and specialized care to critically ill or injured patients. Norwegian HEMS in Central Norway serves an important role in pre-hospital emergency medical care. To grade the severity of patients, HEMS uses the National Advisory Committee on Aeronautics’ (NACA) severity score. The objective of this study was to analyze mortality rates and corresponding NACA values in patients transported by Trondheim HEMS.
Methods: The study uses a retrospective cohort design, aligning with the STROBE recommendations. Patient data from Trondheim HEMS between 01.01.2017 and 31.12.2019 was analyzed. Kaplan Meier plots and cumulative mortality rates were calculated for each NACA group at day one, day 30, and one year and three years after the incident.
Results: Trondheim HEMS responded to 2224 alarms in the included time period, with 1431 patients meeting inclusion criteria for the study. Overall mortality rates at respective time points were 10.1% at day one, 13.4% at 30 days, 18.5% at one year, and 22.3% at three years. The one-year cumulative mortality rates for each NACA group were as follows: 0% for NACA 1 and 2, 2.9% for NACA 3, 10.1% for NACA 4, 24.7% for NACA 5 and 49.5% for NACA 6. Statistical analysis with a global log-rank test indicated a significant difference in survival outcomes among the groups (p < 2×10-16).
Conclusion: The research identifies elevated short- and long-term mortality among patients transported by Trondheim HEMS, and clearly show an incremental rise in mortality rates with increasing NACA scores. Findings align with previous studies but reveal variations, potentially influenced by interpretation differences, regional disparities, and advancements in medical technology. The study further suggests that a one-year follow-up may be sufficient for future investigations into HEMS outcomes. This paper provides valuable reference points for physicians using the NACA score, and further validates the NACA score as a severity scoring system.
Conceptualisation of health among young people: a protocol for systematic review and thematic synthesis of qualitative studies
Authors: Metsis Katrin , Inchley Joanna , Williams Andrew James , Vrahimis Sebastian , Brown Lamorna , Sullivan Frank 
Published: January 2024

Abstract
Background
Self-reported health is a widely used health indicator in surveys and questionnaires. The measure gained attention when research identified its association with mortality in the 1970s and 1980s. The measure is also associated with morbidity and other health outcomes such as the utilisation of health services. Self-reported health is a particularly useful measure for young people because this age group is generally clinically healthy. However, self-reported health starts to decline during early adolescence. It is known that many chronic conditions have long latency periods that are initiated early in life. Despite its widespread use, however, self-reported health remains a poorly understood concept.
Methods
This paper presents the protocol for a systematic review that will identify and synthesise qualitative studies that investigate how young people conceptualise health in the survey context, and overall. The population of the review is young people aged 10–24 years, with or without health conditions. We will search the databases of MEDLINE (Ovid®), PsycINFO (APA PsycNet), ProQuest Sociology Collection, and Web of Science Core Collection™. We will also utilise techniques of reference checking and forward citation searching, as this strategy has been shown to result in a higher number of high-quality studies in social science systematic reviews. Google Scholar and Google Search were used during preliminary searches; Google Scholar is utilised for forward citation searching. We will include studies written in English, German, or Finnish; there will be no lower date limit. One reviewer will screen all citations. A second reviewer will independently screen a sample of 20% of the abstracts. Data will be extracted by one researcher, two other researchers will independently review all data extracted, and quality appraisal completed by the first reviewer. We will utilise the Quality Framework for the appraisal of included articles, and thematic analysis to synthesise selected qualitative studies.
Discussion
The results of this systematic review will improve the understanding of the self-assessments of health and the interpretation of the results of quantitative research. Also, an improved understanding of the conceptualisation of health will inform the development of health policies and interventions that support young people’s health.
Systematic review registration
PROSPERO CRD42022367519
Effects of newer anti-hyperglycemic agents on cardiovascular outcomes in older adults: systematic review and meta-analysis
Authors: Bilal Anika , Yi Fanchao , Gonzalez Gonzalo Romero , Ali Mehreen , Im KyungAh , Ruff Christian T. , Thethi Tina K. , Pratley Richard E. 
Published: January 2024

Abstract

Background
Older adults have higher prevalence of Type 2 diabetes (T2D) and cardiovascular disease. Newer anti-hyperglycemic agents (dipeptidyl peptidase-4 inhibitors [DPP-4i], glucagon-like peptide-1 receptor agonists [GLP-1RA], and sodium/glucose cotransporter 2 inhibitors [SGLT-2i]) demonstrated cardiovascular safety but consistency across older age-groups remains underexplored. In this meta-analysis of randomized controlled trials, we assessed effects of newer anti-hyperglycemic drugs on cardiovascular outcomes in subgroups of older adults.
Methods
PubMed and Cochrane were searched for cardiovascular outcome trials (CVOTs) testing newer agents until August 31, 2022. (PROSPERO ID CRD42021260167) Studies with ≥ 1000 T2D participants enrolled for ≥12 months were included. Random effect models were used to report relative-risk (RR) for three-point major adverse cardiovascular events (3P-MACE) and its components by age subgroups (65 years; 75 years). The p-value
< 0.05 was considered statistically significant.
Results
For SGLT-2is, five CVOTs (46,969 patients, 45–50% ≥65 years) were included. SGLT-2is reduced risk of MACE (RR;0.91[CI,0.85 – 0.98]); cardiovascular death (CV-death) (RR;0.84[CI,0.73 – 0.96]); and all-cause mortality (ACM) (RR;0.86[CI,0.79 – 0.93]) with no difference in subgroups <65 or ≥65 years. Similar results were observed for subgroups <75 or ≥75 years with 10%, 18% and 15% reduction in MACE, CV-death and ACM respectively, and no significant difference between the age subgroups (p-interaction for MACE=0.74; CV-death=0.97; ACM=0.68).
For GLP-1RAs, nine CVOTs (n=64,236, 34–75% ≥65 years) were included. GLP-1RAs reduced risk of MACE (RR;0.89[CI,0.83 – 0.95]), stroke (RR;0.86[CI,0.76 – 0.97]) and ACM (RR;0.90[CI,0.83 – 0.97]) with no significant difference in subgroups <65 or ≥65 years. Additionally, GLP-1RAs reduced risk of MACE (10%), ACM (12%) and CV-death (12%) with no significant difference in age subgroups <75 or ≥75 years.
Four CVOTs (n=33,063; 35 – 58% ≥65 years) with DPP-4is were included. There were no significant differences in risk for CV outcomes with DPP-4is compared to placebo in any of the age subgroups.
Conclusion
The overall cardiovascular outcomes of newer anti-hyperglycemic agents are consistent across the older and younger individuals.
Psychiatric Implications of Anti-seizure Medications in Epileptic Population
Authors: Khalid Bushra , Waqar Zaid , khan Soban , Ali Ijaz , Afzal Naheed , Irfan Anum , Malik Waleed , Adil Malik Muhammad , Saddiqa Amina , Khalil Maryam , Munawar Zeeshan 
Published: January 2024

Abstract
BACKGROUND AND OBJECTIVE: Epilepsy is a common neurological complaint that is impacting millions of people worldwide. It's linked with a high frequency of psychiatric comorbidities, which can have a substantial impact on cases' living standards. The objective of this study was to probe the connotation between antiseizure treatments and the risk of psychiatric comorbidities in cases with epilepsy.METHODOLOGY: For this study data was collected from Patients Neurology referral centre in Islamabad, Pakistan. Data was collected from 120 cases with epilepsy using a structured questionnaire. The questionnaire included questions about seizure control, anti-seizure drug use, and psychiatric comorbidities. Data was analyzed using the SPSS.RESULTS The results showed that cases who were taking antiseizure drugs had a significantly advanced risk of developing psychiatric comorbidities compared to those who weren't taking these drugs( p = .012). Among the antiseizure drugs, cases taking valproate had an advanced risk of developing psychiatric comorbidities, although this wasn't statistically significant (p = .076). Cases with abnormal MRI findings had an advanced risk of developing psychiatric comorbidities (p = .021).CONCLUSION Our study suggests that cases with epilepsy who are taking antiseizure drugs are at an advanced risk of developing psychiatric comorbidities compared to those who aren't taking these drugs. Thus, close monitoring of cases taking antiseizure drugs for psychiatric comorbidities is recommended.
Analyses of the overlength control region in Metacarcinus magister (Decapoda: Brachyura) and phylogenetic study of Menippidae species
Authors: Wang Zhengfei , Xu Xinyi , Zheng Yuqing , Xu Zhiwen , Li Yunjie , Chen Huohuo 
Published: January 2024

Abstract
The complete mitochondrial genomes (mitogenomes) can provide important information for molecular evolution and phylogenetic relationships of marine invertebrates, especially in Brachyura. Menippidae species are representative of typical marine crabs, but only two Menippidae species mitogenomes were sequenced previously, and the phylogenetic relationships of the class Menippidae (Decapoda: Brachyura: Eriphioidea) remain to be resolved. In this research, the mitogenomic characteristics of Metacarcinus magister (Eriphioidea: Menippidae) has been newly studied. The length of M. magister was 48,820 bp, which contained the typical 13 protein-coding genes, 2 ribosomal RNA genes, and 22 transfer RNA genes. We did a series of analyses surrounding the characteristics of Metacarcinus magister CR. Phylogenetic analysis, life circumstances and selective pressures were all tried to explain the formation of this length, which was emerged approximately three times compared with the normal length of Brachyuran mitogenomes. Phylogenetic analyses based on the dataset of 132 Decapodan mitogenomes indicated that all the Menippidae crabs clustered together as a group. In the clade, M. magister was related to all the other four Menippidae species, such as Pseudocarcinus gigas and Myomenippe fornasinii. Moreover, the rearrangement mechanism of these four species has been predicted to provide stronger evidence for phylogenetic analysis. In general, the results obtained in this study will contribute to a better understanding of the cause of the unusual length of M. magister, and provide new insights into the phylogeny of Brachyura.