bluuebunny/crossref_metadata_2025_split huggingface dataset:
Predictors of therapeutic response following thalamic neuromodulation for drug‐resistant pediatric epilepsy: A systematic review and individual patient data meta‐analysis
Authors: Sharma Akshay , Parfyonov Maksim , Tiefenbach Jakov , Hogue Olivia , Nero Neil , Jehi Lara , Serletis Demitre , Bingaman William , Gupta Ajay , Rammo Richard 
Published: January 2024

AbstractWe sought to perform a systematic review and individual participant data meta‐analysis to identify predictors of treatment response following thalamic neuromodulation in pediatric patients with medically refractory epilepsy. Electronic databases (MEDLINE, Ovid, Embase, and Cochrane) were searched, with no language or data restriction, to identify studies reporting seizure outcomes in pediatric populations following deep brain stimulation (DBS) or responsive neurostimulation (RNS) implantation in thalamic nuclei. Studies featuring individual participant data of patients with primary or secondary generalized drug‐resistant epilepsy were included. Response to therapy was defined as >50% reduction in seizure frequency from baseline. Of 417 citations, 21 articles reporting on 88 participants were eligible. Mean age at implantation was 13.07 ± 3.49 years. Fifty (57%) patients underwent DBS, and 38 (43%) RNS. Sixty (68%) patients were implanted in centromedian nucleus and 23 (26%) in anterior thalamic nucleus, and five (6%) had both targets implanted. Seventy‐four (84%) patients were implanted bilaterally. The median time to last follow‐up was 12 months (interquartile range = 6.75–26.25). Sixty‐nine percent of patients achieved response to treatment. Age, target, modality, and laterality had no significant association with response in univariate logistic regression. Until thalamic neuromodulation gains widespread approval for use in pediatric patients, data on efficacy will continue to be limited to small retrospective cohorts and case series. The inherent bias of these studies can be overcome by using individual participant data. Thalamic neuromodulation appears to be a safe and effective treatment for epilepsy. Larger, prolonged prospective, multicenter studies are warranted to further evaluate the efficacy of DBS over RNS in this patient population where resection for curative intent is not a safe option.
Happy parents, happy kids: Marital happiness, parenting styles, and children's behavioral outcomes in Chinese societies
Authors: Huang Ching‐Yu , Shen April Chiung‐Tao , Li Xuan , Feng Joyce Yen 
Published: January 2024

ABSTRACTObjectiveWe examine the impacts of parental marital happiness on child outcomes. We also examine the potential mediating role of parenting styles in the relationship between marital happiness and children's behavioral outcomes.BackgroundParents' marital happiness lays a crucial foundation for successful parenthood, which contributes to children's positive development. However, scant research has examined the relationship between parental marital happiness and child outcomes in Chinese populations.MethodData from a subsample of 3,258 parents of third‐grade children in Shanghai and Greater Taipei were analyzed (n = 1,285 from Shanghai; 1,973 from Greater Taipei). We conducted hierarchical multiple regression analyses to investigate whether marital happiness is a significant predictor of children's behavioral outcomes, adjusted for four covariates: parent gender, child gender, site, and subjective social status. We also conducted parallel mediation analyses to examine parenting styles as mediators.ResultsOur findings reveal that in both Shanghai and Greater Taipei, marital happiness was positively associated with authoritative parenting style and negatively associated with harsh parenting style. Moreover, marital happiness was significantly associated with children's behavioral outcomes, even after covariates were accounted for. Our parallel mediation analysis reveals that marital happiness had significant direct and indirect effects on children's behavioral outcomes through authoritative and harsh parenting styles.ConclusionOur findings demonstrate the pivotal importance of parental marital happiness in healthy child development.ImplicationsIntervention programs promoting child welfare in Chinese communities should include interparental relations. Public resources should raise awareness of marital happiness and offer guidance and support for high‐quality relationships.
A review of extension programs serving military Veterans and their families
Authors: Younker Terasa , Radunovich Heidi Liss 
Published: January 2024

AbstractTo better understand the availability and quality of current Extension programming for Veterans and their families, the researchers reviewed the academic literature (yielding 12 publications) and conducted an online scan of Extension programs (yielding 112 resources). Programs discovered fell across nine areas: occupational training/support, mental health support, service to Veterans, family support, livelihood support, holistic support, life quality, healthcare access/quality, and community development. This study revealed that, while Extension programs exist for Veterans and their families, program coordination, needs assessments from Veteran populations, and better program evaluations are needed to maximize efficacy of Extension programs serving Veteran populations.
Fabrication and characterisation of Pickering emulsion‐based oleogel stabilised by citrus fibre and whey protein isolate colloidal complex: application in cookie formulation
Authors: Genc Ezgi , Karasu Salih , Akcicek Alican , Toker Omer Said 
Published: January 2024

SummaryIn this study, the oleogel was produced by Pickering emulsion‐based method by using citrus fibre (CF)‐whey protein isolate (WPI) colloidal complex. The obtained oleogels were characterised by rheological and textural properties, and then the oleogels were used in cookies as an alternative to palm oil. The four oleogels (1% to 5%) were fabricated using a CF‐10% WPI complex. Shear thinning rheological behaviour was observed in all emulsion and oleogel samples. The G values were greater than the G values, indicating that solid‐like behaviour dominated in all emulsion and oleogel samples. All oleogel samples had a higher than 90% oil‐holding capacity. The visual appearance of 3% CF‐10% WPI and 5% CF‐10% WPI showed no surface oil, and more integrity structure means that could well trap oil in a gel matrix. Increasing CF% concentration reduced oil droplets and created a more compact structure, particularly at 3% and 5% CF‐10% WPI. An increase in CF concentration from 2% to 5% led to an increase in the hardness value of the dried products and cookies that CF formed a 3D network structure with binds liquid oil. The oxidative stability showed that no significant changes were found between the 3% CF‐10% WPI and palm cookies (P < 0.05). Cookies containing oleogels with a 3% CF content exhibited a visual resemblance to this trait, suggesting a colour appearance that closely resembled cookies made with palm oil. The incorporation of oleogels into the cookie recipe proved to be an effective substitute for palm oil. CF‐10% WPI oleogels show promise for use in cookie preparation as a replacement for palm oil, offering potential as substitutes for saturated and trans fats in food products.
Comprehensive phenolic profiling of Australian‐grown Progrades™Desmanthus through LC‐ESI‐QTOF‐MS2 and determination of their antioxidant potential
Authors: Kang Xi , Guo Siwei , Xie Cundong , Gardiner Christopher , Kempe Nick , Suleria Hafiz A. R. , Dunshea Frank R. 
Published: January 2024

SummaryDesmanthus is a Mimosaceae legume genus that is native to the Americas. Decades ago, the introduction of Desmanthus with impressive survival ability in semi‐clay soil filled the gap of no sown pasture legume adaptive to the northern Australian environment. In this study, the comprehensive phenolic profile of Progrades™ Desmanthus collected across northwestern Queensland was characterised by LC‐ESI‐QTOF‐MS2. Their antioxidant potential was evaluated by the in vitro antioxidant assays and correlatively analysed with the phenolic contents. As discovered, the phenolic contents varied significantly among geographical locations. Desmanthus collected from Armreynold showed the highest phenolic content mainly consisting of condensed tannins, whereas the Madison region sample displayed the highest flavonoid content. The mass spectrometry results identified 68 phenolic compounds, highlighting 21 phenolic acids and 36 flavonoids. This study provides academic evidence for the utilisation of Desmanthus in food and husbandry industries as an antioxidant ingredient or a potential source of phenolic compounds.
Therapy‐induced senescent cancer cells exhibit complement activation and increased complement regulatory protein expression
Authors: Abu‐Humaidan Anas HA , Ismail Mohammad A , Ahmad Fatima M , Al Shboul Sofian , Barham Raghad , Tadros Joud S , Alhesa Ahmad , El‐Sadoni Mohammed , Alotaibi Moureq R , Ababneh Nidaa A , Saleh Tareq 
Published: January 2024

AbstractTherapy‐induced senescence (TIS) is a primary response to chemotherapy, contributing to untoward treatment outcomes such as evasion of immunosurveillance. Despite the established role of the complement system in the immune response to cancer, the role of complement in mediating the immune response against senescent tumor cells remains poorly understood. To explore this relationship, we exposed lung adenocarcinoma (A549), breast adenocarcinoma (MCF7) and pancreatic carcinoma (Panc‐1) cell lines to sublethal doses of either etoposide or doxorubicin to trigger TIS. Identification of TIS was based on morphological changes, upregulation of the senescence‐associated β‐galactosidase, p21Cip1 induction and lamin B1 downregulation. Using immunofluorescence microscopy, quantitative PCR, ELISA of conditioned media and in silico analysis, we investigated complement activation, complement protein expression, C3 levels in the conditioned media of senescent cells and secreted complement proteins as part of the senescence‐associated secretory phenotype (SASP), respectively. In cell lines undergoing TIS, complement‐related changes included (i) activation of the terminal pathway, evidenced by the deposition of C5b‐9 on senescent cells; (ii) an increase in the expression of CD59 and complement factor H and (iii) in A549 cells, an elevation in the expression of C3 with its secretion into the medium. In addition, increased C3 expression was observed in breast cancer samples expressing TIS hallmarks following exposure to neoadjuvant chemotherapy. In conclusion, TIS led to the activation of complement, upregulation of complement regulatory proteins and increased C3 expression. Complement appears to play a role in shaping the cancer microenvironment upon senescence induction.
Changing landscape of diabetes in Asia – What are the unmet needs?
Authors: Luk Andrea OY 
Published: January 2024

ABSTRACTThe incidence rates of type 2 diabetes among adults in Asia have been stable, but the rates in youth and young adults have increased. In territory‐wide surveillance in Hong Kong, Special Administrative Region of People's Republic of China, all‐cause mortality rates among people with diabetes have exhibited a declining trend in the past 15 years, with a narrowing in the mortality gap between people with and without diabetes. At the same time, the improvement in survival resulted in a changing age structure and disease profile of people with diabetes, towards an increasing proportion of older people with long diabetes duration and multi‐morbidities. Reductions in event rates were not observed in the youngest age group who also had the least gains in risk factor control and uptake in organ protective drugs over time. A young age at diabetes diagnosis, associated with exposure to high glycemic burden from an early age, predicted higher risks of complications and premature mortality compared with later‐onset of diabetes. People presenting with type 2 diabetes below 40 years of age were 5‐fold more likely to die and their life expectancy was shortened by 8 years than age‐matched counterparts without diabetes. Analysis of population‐based data in Hong Kong Chinese identified hypertension followed by chronic kidney disease as the leading contributor to mortality in young people, indicating that efforts to optimize non‐glycemic risk factors and organ protection are as important in young individuals as it is in the older population.
Accuracy of an intraoral scanner with near‐infrared imaging feature in detection of interproximal caries of permanent teeth: An in vivo validation
Authors: Kanar Özlem , Tağtekin Dilek , Korkut Bora 
Published: January 2024

AbstractObjectiveThis study aimed to evaluate the accuracy of an intraoral scanner with near‐infrared imaging (NIRI) feature in the diagnosis of interproximal caries and to compare it with the visual‐tactile method (VTM), bitewing radiography (BWR), and panoramic radiography (PR).Materials and MethodsSix hundred thirty‐nine interproximal surfaces (mesial‐distal) of posterior teeth from 22 volunteers were examined. Results were scored by VTM, BWR, PR, and NIRI. Lesions were scored as 0 for no‐caries, 1 for early‐enamel lesion (EEL), and 2 for lesions involving dentino–enamel junction (DEJ). McNemar, Kappa, and Fleis Kappa tests were used to evaluate the agreement levels. Pearson's Chi‐square test was used to determine the matching rates after validation.ResultsA good level of agreement was observed between examination methods (Ƙ = 0.613; p < 0.001). In pairwise comparisons, a moderate agreement was seen between all the methods for lesions with DEJ involvement, while a statistically good agreement was observed between BWR and NIRI (Ƙ = 0.675; p < 0.001). As a result of validation, the accuracy of NIRI for molars was considered 85.2% and 75.7% for premolars in EELs, 85.2% for molars, and 70% for premolars regarding the lesions involving DEJ.ConclusionsIntraoral scanners with the NIRI feature may be used for diagnosing interproximal caries, especially for permanent molars.Clinical SignificanceEarly detection of proximal caries is one of the most essential topics forming the basis of preventive dentistry. This study investigates a caries diagnostic tool integrated into intraoral scanners to diagnose interproximal caries. A caries diagnostic tool integrated into an intraoral scanner may prevent the harmful effects of ionizing radiation in early caries diagnosis and may improve the patient's oral health status.
Happy Diamond Anniversary JMS! A Decade Analysis of the Journal of Management Studies
Authors: Krammer Sorin M. S. , Dahlin Peter , Doh Jonathan P. , Potočnik Kristina 
Published: January 2024

AbstractThe Journal of Management Studies, founded in 1963, is celebrating its 60th year. Clark et al. (2014) conducted a bibliometric analysis for its 50th anniversary assessing whether the journal had maintained its leading international ranking and sustained its mission to serve as a broad‐based management outlet. In this review, we build on and extend their findings by examining trends in the journal over the past decade (2012–22). We present a broader analysis of JMS by exploring its unique identity within the management journal ecosystem and examining its scope and breadth in terms of topics, methods, and author demographics to document JMS's evolution, impact, reach, and accessibility. We develop a new bibliometric framework that employs a mix of qualitative and quantitative analyses (including regression, text, and language analysis) to cover a broad range of considerations for a journal and its stakeholders. In so doing, we contribute to the bibliometric and review research areas by proposing new metrics (related to diversity, equity, and inclusion) and analysis tools to assess the relative position of an academic journal. Employing this framework, we conclude that JMS has retained and enhanced its position as a leading, cutting‐edge general management journal.
Different minimal alcohol consumption in male and female individuals with metabolic dysfunction‐associated fatty liver disease
Authors: Zhu Yixuan , Xu Xiaoming , Fan Zhiwen , Ma Xiaoyan , Rui Fajuan , Ni Wenjing , Hu Xinyu , Gu Qi , Shi Junping , Wu Chao , Yeo Yee Hui , Li Jie 
Published: January 2024

AbstractBackground and AimsThe relationship between moderate alcohol intake and health outcomes among individuals with metabolic dysfunction‐associated fatty liver disease (MAFLD) is complex. Our aim was to investigate the association of minimal alcohol consumption with all‐cause and cause‐specific mortality among MAFLD individuals of different genders.MethodsOur study included 2630 MAFLD individuals from the Third National Health and Nutrition Examination Survey. Cox regression analysis was performed to assess the association between alcohol use measures and all‐cause and cause‐specific mortality. Restricted cubic spline curves were used to evaluate the relationship between alcohol consumption per week and all‐cause mortality.ResultsIn the entire MAFLD cohort, we observed significant disparities in clinical characteristics between male and female individuals with MAFLD. Higher weekly alcohol consumption was significantly associated with all‐cause and cause‐specific mortality (male, hazard ratios [HRs]: 1.009, 95% CIs: 1.004–1.014; female, HRs: 1.032, 95% CIs: 1.022–1.042). In males with MAFLD, a linear association with all‐cause mortality was observed for weekly alcohol consumption (p for non‐linearity = .21). Conversely, in females with MAFLD, the risk of all‐cause mortality remained relatively stable until 2 drinks per week, after which it rapidly increased with each additional drink consumed, and the increase in mortality risk was higher than that observed in males (p for non‐linearity < .05).ConclusionsOur findings indicate that any increase in weekly alcohol consumption was associated with increased all‐cause mortality in men with MAFLD. Conversely, consuming less than 2 drinks per week had minimal impact on the risk of mortality among female.
Secondary peristalsis and esophagogastric junction distensibility in symptomatic post‐fundoplication patients
Authors: Lu Michelle M. , Kahrilas Peter J. , Teitelbaum Ezra N. , Pandolfino John E. , Carlson Dustin A. 
Published: January 2024

AbstractBackgroundThe impact of esophageal dysmotility among patients with post‐fundoplication esophageal symptoms is not fully understood. This study aimed to investigate secondary peristalsis and esophagogastric junction (EGJ) opening biomechanics using functional lumen imaging probe (FLIP) panometry in symptomatic post‐fundoplication patients.MethodsEighty‐seven adult patients post‐fundoplication who completed FLIP for symptomatic esophageal evaluation were included. Secondary peristaltic contractile response (CR) patterns and EGJ opening metrics (EGJ distensibility index (EGJ‐DI) and maximum EGJ diameter) were evaluated on FLIP panometry and analyzed against high‐resolution manometry (HRM), patient‐reported outcomes, and fundoplication condition seen on esophagram and/or endoscopy.Key ResultsFLIP CR patterns included 14 (16%) normal CR, 30 (34%) borderline CR, 28 (32%) impaired/disordered CR, 13 (15%) absent CR, and 2 (2%) spastic reactive CR. Compared with normal and borderline CRs (i.e., CR patterns with distinct, antegrade peristalsis), patients with impaired/disordered and absent CRs demonstrated significantly greater time since fundoplication (2.4 (0.6–6.8) vs. 8.9 (2.6–14.5) years; p = 0.002), greater esophageal body width on esophagram (n = 50; 2.3 (2.0–2.8) vs. 2.9 (2.4–3.6) cm; p = 0.013), and lower EGJ‐DI (4.3 (2.7–5.4) vs. 2.6 (1.7–3.7) mm2/mmHg; p = 0.001). Intact fundoplications had significantly higher rates of normal CRs compared to anatomically abnormal (i.e., tight, disrupted, slipped, herniated) fundoplications (9 (28%) vs. 5 (9%); p = 0.032), but there were no differences in EGJ‐DI or EGJ maximum diameter.Conclusions & InferencesSymptomatic post‐fundoplication patients were characterized by frequent abnormal secondary peristalsis after fundoplication, potentially worsening with time after fundoplication or related to EGJ outflow resistance.
The SlGRAS9‐SlZHD17 transcriptional cascade regulates chlorophyll and carbohydrate metabolism contributing to fruit quality traits in tomato
Authors: Shi Yuan , Hu Guojian , Wang Yan , Liang Qin , Su Deding , Lu Wang , Deng Wei , Bouzayen Mondher , Liu Yudong , Li Zhengguo , Huang Baowen 
Published: January 2024

Summary

Some essential components of fleshy fruits are dependent on photosynthetic activity and carbohydrate metabolism. Nevertheless, the regulatory mechanisms linking chlorophyll and carbohydrate metabolism remain partially understood.

Here, we uncovered the role of SlGRAS9 and SlZHD17 transcription factors in controlling chlorophyll and carbohydrate accumulation in tomato fruit. Knockout or knockdown of SlGRAS9 or SlZHD17 resulted in marked increase in chlorophyll content, reprogrammed chloroplast biogenesis and enhanced accumulation of starch and soluble sugars.

Combined genome‐wide transcriptomic profiling and promoter‐binding experiments unveiled a complex mechanism in which the SlGRAS9/SlZHD17 regulatory module modulates the expression of chloroplast and sugar metabolism either via a sequential transcriptional cascade or through binding of both TFs to the same gene promoters, or, alternatively, via parallel pathways where each of the TFs act on different target genes. For instance, the regulation of SlAGPaseS1 and SlSUS1 is mediated by SlZHD17 whereas that of SlVI and SlGLK1 occurs only through SlGRAS9 without the intervention of SlZHD17. Both SlGRAS9 and SlZHD17 can also directly bind the promoter of SlPOR‐B to regulate its expression.

Taken together, our findings uncover two important regulators acting synergistically to manipulate chlorophyll and carbohydrate accumulation and provide new potential breeding targets for improving fruit quality in fleshy fruits.
The global distribution of angiosperm genome size is shaped by climate
Authors: Bureš Petr , Elliott Tammy L. , Veselý Pavel , Šmarda Petr , Forest Félix , Leitch Ilia J. , Nic Lughadha Eimear , Soto Gomez Marybel , Pironon Samuel , Brown Matilda J. M. , Šmerda Jakub , Zedek František 
Published: January 2024

Summary
Angiosperms, which inhabit diverse environments across all continents, exhibit significant variation in genome sizes, making them an excellent model system for examining hypotheses about the global distribution of genome size. These include the previously proposed large genome constraint, mutational hazard, polyploidy‐mediated, and climate‐mediated hypotheses.
We compiled the largest genome size dataset to date, encompassing 16 017 (> 5% of known) angiosperm species, and analyzed genome size distribution using a comprehensive geographic distribution dataset for all angiosperms.
We observed that angiosperms with large range sizes generally had small genomes, supporting the large genome constraint hypothesis. Climate was shown to exert a strong influence on genome size distribution along the global latitudinal gradient, while the frequency of polyploidy and the type of growth form had negligible effects. In contrast to the unimodal patterns along the global latitudinal gradient shown by plant size traits and polyploid proportions, the increase in angiosperm genome size from the equator to 40–50°N/S is probably mediated by different (mostly climatic) mechanisms than the decrease in genome sizes observed from 40 to 50°N northward.
Our analysis suggests that the global distribution of genome sizes in angiosperms is mainly shaped by climatically mediated purifying selection, genetic drift, relaxed selection, and environmental filtering.