bluuebunny/crossref_metadata_2025_split huggingface dataset:
Failure mode and effects analysis using an improved pignistic probability transformation function and grey relational projection method
Authors: Tang Yongchuan , Sun Zhaoxing , Zhou Deyun , Huang Yubo 
Published: November 2023

AbstractFailure mode and effects analysis (FMEA) is an important risk analysis tool that has been widely used in diverse areas to manage risk factors. However, how to manage the uncertainty in FMEA assessments is still an open issue. In this paper, a novel FMEA model based on the improved pignistic probability transformation function in Dempster–Shafer evidence theory (DST) and grey relational projection method (GRPM) is proposed to improve the accuracy and reliability in risk analysis with FMEA. The basic probability assignment (BPA) function in DST is used to model the assessments of experts with respect to each risk factor. Dempster’s rule of combination is adopted for fusion of assessment information from different experts. The improved pignistic probability function is proposed and used to transform the fusion result of BPA into probability function for getting more accurate decision-making result in risk analysis with FMEA. GRPM is adopted to determine the risk priority order of all the failure modes to overcome the shortcoming in traditional risk priority number in FMEA. Applications in aircraft turbine rotor blades and steel production process are presented to show the rationality and generality of the proposed method.
Blue light photoinhibition of Streptococcus mutans: potential chromophores and mechanisms
Authors: Mohamad Sherif A. , Megson Ian L. , Kean Alistair H. 
Published: November 2023

AbstractThe direct application of blue light (λ = 400–500 nm) provides a promising antimicrobial modality, the effects of which are mediated through generation of reactive oxygen species. Porphyrins are organic compounds essential for bacterial synthesis of heme and are understood to be the main blue light chromophores within bacteria, which are critical to the sensitivity to blue light. However, Streptococcus mutans — the principal etiological species of dental caries — has shown susceptibility towards blue light despite reportedly lacking heme synthesis pathways, raising a question as to how this susceptibility is mediated. S. mutans lacks heme-containing cytochromes for full aerobic respiration, instead relying mainly on flavin adenine dinucleotide enzymes for oxygen-dependent metabolism. This review article investigates the potential target chromophores and mechanisms underpinning the inhibitory effects of blue light in S. mutans. Multiple reports support the proposition that bacteria with blocked heme synthetic pathways still possess the genetic antecedents capable of generating porphyrins and heme proteins under appropriate conditions. Blue light is absorbed by flavins, and hence, the flavoenzymes also represent potential chromophores. In conclusion, depending on in-vitro growth and metabolic conditions, there is more than one blue light chromophore within S. mutans. To optimise clinical application of blue light-induced antimicrobial effects, future investigations should focus on in-vivo models and clinical trials.
Design new strategies and photocatalytic performances of (NH4)Cd6(P2O7)2 P3O10 nanostructures
Authors: Gnanamoorthy G. , Ali Daoud , Yadav Virendra Kumar , Narayanan V. 
Published: November 2023

AbstractNew (NH4)Cd6(P2O7)2 P3O10 nano-multi shapes were prepared by hydrothermal method and which can be examined by various using instruments like X-ray diffraction, FTIR and Raman spectroscopy measurements. These (NH4)Cd6(P2O7)2 P3O10 nanocatalysts were obtained to the monoclinic structure. The (NH4)Cd6(P2O7)2 P3O10 nanocatalyst morphologies were analyzed in SEM instrument and spheres like structures, triangle, cubic and crystal shapes also obtained. Peaks 484, 557 and 1087 cm−1 were corresponds to the M–O and P–O groups, which results were confirmed by FT-IR studies. This (NH4)Cd6(P2O7)2 P3O10 materials synergism can be described in photocatalytic applications. At this juncture, these nanoparticles can be created to the new invention and effectible performed to the Brilliant Green dye efficiency with halogen lamp.
The National Israeli Registry for Oculo-Pharyngeal Muscular Dystrophy (IsrO-PMD): rationale and design
Authors: Stern Jonah E. , Zvulunov Alex , Dori Amir , Charas Hagit , Benyamini Limor , Simon Guy Ben , Mentzer Lilya , Greenbaum Lior , Friedlander-Barenboim Silvina , Shelly Shahar 
Published: November 2023

Abstract
Background
Oculo-pharyngeal muscular dystrophy (OPMD) is a rare disease, caused by trinucleotide repeat expansion in the PABPN1 gene, inherited in an autosomal dominant (AD) manner. Its main features are eyelid ptosis and dysphagia, which manifest at the end of the fifth decade of life. Other symptoms include proximal muscle weakness and bulbar muscle weakness. Although OPMD is prevalent worldwide, a higher prevalence has been reported in the Jewish population from Bukhara. Currently, no specific drugs are available for OPMD.

Objective
Our National Israeli Registry for Oculo-Pharyngeal Muscular Dystrophy (IsrO-PMD) study aims to provide a framework for the assessment and documentation of the natural history of the diseases as we as a multi-disciplinary management of patients with OPMD. The IsrO-PMD may be the cornerstone of future clinical trials for novel therapies for OPMD.

Methods
The IsrO-PMD is a national prospective registry that involves non-interventional data collection based on the Global Rare Diseases Patient Registry (GRDPR) and data repository standard. Inclusion criteria are clinical diagnosis of OPMD and positive genetic testing. Patients who meet inclusion criteria will be examined using a series of multi-disciplinary investigations and questionnaires including periodic follow-up examinations. Specific attention is given to comprehensive neurological, swallowing, and ophthalmological evaluations.

Discussion
The establishment of this national registry will enhance our understanding of the natural history of OPMD, establish quality care benchmarks, and develop treatment strategies in addressing the multi-system pathophysiology of the disease and associated comorbidities. Our registry provides a foundation for the use of new cutting-edge treatments as they become available.
High‐Energy Electron Flux Enhancement Pattern in the Outer Radiation Belt in Response to the Interplanetary Coronal Mass Ejections
Authors: Da Silva L. A. , Shi J. , Marchezi J. P. , Agapitov O. V. , Sibeck D. , Alves L. R. , Vieira L. E. A. , Deggeroni V. , Resende L. C. A. , Lopez R. , Costa J. E. R. , Wang C. , Moro J. , Li H. , Lago A. Dal , Ferreira K. J. C. , Inostroza A. , Liu Z. 
Published: November 2023

AbstractThe high‐energy electron flux enhancement pattern in the outer radiation belt is observed under the influence of the Interplanetary Coronal Mass Ejections (ICMEs). Ten events were selected during the Van Allen Probes era, with the high‐energy electron flux enhancement starting close to L* = 4. A schematic diagram of the main physical processes responsible for this kind of high‐energy electron flux enhancement is presented, considering the energy deposited in the inner magnetosphere under the influence of ICMEs. Superposed Epoch Analysis is applied to the interplanetary medium parameters, the magnetopause standoff distance, the storm‐time geomagnetic activity indices, the Ultra‐Low Frequency (ULF) waves, and the whistler‐mode chorus waves. A compressed magnetopause, Bz component preferentially southward and storm indices considerably high are observed at the beginning of the electron flux enhancements. The modeled parameters of the chorus waves at the dayside/nightside sectors show the high acceleration efficiency at the beginning of the electron flux enhancement pattern II. These results suggest that the local acceleration driven by chorus waves is essential to these electron flux enhancements at low L*. In contrast, although the ULF waves are detected at the beginning of the studied electron flux enhancements, their contribution is insignificant.
Stress‐Induced Anisotropic Poroelasticity in Westerly Granite
Authors: Elsigood Bobby , Brantut Nicolas , Meredith Philip G. , Healy David , Mitchell Thomas M. , Aben Frans M. 
Published: November 2023

AbstractWe measured poroelastic properties of cracked granite under triaxial conditions, at elevated confining pressure and a range of differential stresses. Skempton's coefficients and undrained Young's modulus and Poisson's ratio were determined directly by recording in situ fluid pressure during rapid cycles of axial and radial stress. Drained properties were measured both statically and dynamically at ultrasonic frequencies. At a given confining pressure, increasing differential stress leads to the development of elastically transverse isotropy, with symmetry axis aligned with the compression axis. Skempton's coefficients are also anisotropic, with larger changes in pore pressure in response to radial stress (coefficient Bx) than to axial stress steps (Bz). The anisotropy in the Skempton coefficients increases with increasing differential stress, with Bz decreasing and Bx slightly increasing. The evolution of static moduli and the Skempton coefficients is well approximated by Gassmann's equation using dry moduli obtained from ultrasonic measurements. Simplified predictions of the Skempton coefficients based on crack density tensors inverted from dynamic data also shows acceptable agreement with direct observations. Perfect quantitative agreement is not reached, due to the imprecision of our dynamic measurements, model simplifications, and inherent differences between static moduli obtained using stress steps of several MPa stress and dynamic ultrasonic stress oscillations.
Atmospheric Meridional Circulation Between South Asia and Tibetan Plateau Caused by the Change of Planetary Boundary Layer Depth
Authors: Zhao Ping , Li Yilin , Jia Chunhui , Che Junhui 
Published: November 2023

AbstractPlanetary boundary layer (PBL) influences the vertical exchanges of momentum, heat, water vapor, atmospheric pollutants, and the efficacy of climate forcing between land surface and atmosphere. Over the western Tibetan Plateau (TP), PBL can stretch into the middle‐upper troposphere. In this study, we investigate an effect of the PBL depth change on atmospheric circulations between South Asia and the TP through the formula derivation, the observation, and the model data set. The derivation first gives the PBL depth‐generalized pressure equation. It reveals an effect of PBL depth on the pressure change with time. The data analysis further shows that an increase of PBL depth in the western TP can cause the subsequent development of the PBL low (high) pressure anomalies in the northwestern TP (northern South Asia) and the upper‐tropospheric high (low) pressure anomalies over the TP (South Asia), with an anticlockwise meridional‐vertical circulation (MVC) anomaly from South Asia to the TP. In this process, the peak of PBL depth may be ahead of that of the low‐pressure occurrence, which may cause the MVC development to lag behind surface heating. The anticlockwise MVC anomaly strengthens the transport of water vapor from the lower troposphere over South Asia to the TP PBL, producing convective precipitation in the TP.
Comparable roles for serotonin in rats and humans for computations underlying flexible decision-making
Authors: Luo Qiang , Kanen Jonathan W. , Bari Andrea , Skandali Nikolina , Langley Christelle , Knudsen Gitte Moos , Alsiö Johan , Phillips Benjamin U. , Sahakian Barbara J. , Cardinal Rudolf N. , Robbins Trevor W. 
Published: November 2023

AbstractSerotonin is critical for adapting behavior flexibly to meet changing environmental demands. Cognitive flexibility is important for successful attainment of goals, as well as for social interactions, and is frequently impaired in neuropsychiatric disorders, including obsessive–compulsive disorder. However, a unifying mechanistic framework accounting for the role of serotonin in behavioral flexibility has remained elusive. Here, we demonstrate common effects of manipulating serotonin function across two species (rats and humans) on latent processes supporting choice behavior during probabilistic reversal learning, using computational modelling. The findings support a role of serotonin in behavioral flexibility and plasticity, indicated, respectively, by increases or decreases in choice repetition (‘stickiness’) or reinforcement learning rates following manipulations intended to increase or decrease serotonin function. More specifically, the rate at which expected value increased following reward and decreased following punishment (reward and punishment ‘learning rates’) was greatest after sub-chronic administration of the selective serotonin reuptake inhibitor (SSRI) citalopram (5 mg/kg for 7 days followed by 10 mg/kg twice a day for 5 days) in rats. Conversely, humans given a single dose of an SSRI (20 mg escitalopram), which can decrease post-synaptic serotonin signalling, and rats that received the neurotoxin 5,7-dihydroxytryptamine (5,7-DHT), which destroys forebrain serotonergic neurons, exhibited decreased reward learning rates. A basic perseverative tendency (‘stickiness’), or choice repetition irrespective of the outcome produced, was likewise increased in rats after the 12-day SSRI regimen and decreased after single dose SSRI in humans and 5,7-DHT in rats. These common effects of serotonergic manipulations on rats and humans—identified via computational modelling—suggest an evolutionarily conserved role for serotonin in plasticity and behavioral flexibility and have clinical relevance transdiagnostically for neuropsychiatric disorders.
Immunity-and-matrix-regulatory cells enhance cartilage regeneration for meniscus injuries: a phase I dose-escalation trial
Authors: Huang Liangjiang , Zhang Song , Wu Jun , Guo Baojie , Gao Tingting , Shah Sayed Zulfiqar Ali , Huang Bo , Li Yajie , Zhu Bo , Fan Jiaqi , Wang Liu , Xiao Yani , Liu Wenjing , Tian Yao , Fang Zhengyu , Lv Yingying , Xie Lingfeng , Yao Sheng , Ke Gaotan , Huang Xiaolin , Huang Ying , Li Yujuan , Jia Yi , Li Zhongwen , Feng Guihai , Huo Yan , Li Wei , Zhou Qi , Hao Jie , Hu Baoyang , Chen Hong 
Published: November 2023

AbstractImmunity-and-matrix-regulatory cells (IMRCs) derived from human embryonic stem cells have unique abilities in modulating immunity and regulating the extracellular matrix, which could be mass-produced with stable biological properties. Despite resemblance to mesenchymal stem cells (MSCs) in terms of self-renew and tri-lineage differentiation, the ability of IMRCs to repair the meniscus and the underlying mechanism remains undetermined. Here, we showed that IMRCs demonstrated stronger immunomodulatory and pro-regenerative potential than umbilical cord MSCs when stimulated by synovial fluid from patients with meniscus injury. Following injection into the knees of rabbits with meniscal injury, IMRCs enhanced endogenous fibrocartilage regeneration. In the dose-escalating phase I clinical trial (NCT03839238) with eighteen patients recruited, we found that intra-articular IMRCs injection in patients was safe over 12 months post-grafting. Furthermore, the effective results of magnetic resonance imaging (MRI) of meniscus repair and knee functional scores suggested that 5 × 107 cells are optimal for meniscus injury treatment. In summary, we present the first report of a phase I clinical trial using IMRCs to treat meniscus injury. Our results demonstrated that intra-articular injection of IMRCs is a safe and effective therapy by providing a permissive niche for cartilage regeneration.
Prph2 knock-in mice recapitulate human central areolar choroidal dystrophy retinal degeneration and exhibit aberrant synaptic remodeling and microglial activation
Authors: Ruiz-Pastor María José , Sánchez-Sáez Xavier , Kutsyr Oksana , Albertos-Arranz Henar , Sánchez-Castillo Carla , Ortuño-Lizarán Isabel , Martínez-Gil Natalia , Vidal-Gil Lorena , Méndez Lucía , Sánchez-Martín Manuel , Maneu Victoria , Lax Pedro , Cuenca Nicolás 
Published: November 2023

AbstractCentral areolar choroidal dystrophy is an inherited disorder characterized by progressive choriocapillaris atrophy and retinal degeneration and is usually associated with mutations in the PRPH2 gene. We aimed to generate and characterize a mouse model with the p.Arg195Leu mutation previously described in patients. Heterozygous (Prph2WT/KI) and homozygous (Prph2KI/KI) mice were generated using the CRISPR/Cas9 system to introduce the p.Arg195Leu mutation. Retinal function was assessed by electroretinography and optomotor tests at 1, 3, 6, 9, 12, and 20 months of age. The structural integrity of the retinas was evaluated at the same ages using optical coherence tomography. Immunofluorescence and transmission electron microscopy images of the retina were also analyzed. Genetic sequencing confirmed that both Prph2WT/KI and Prph2KI/KI mice presented the p.Arg195Leu mutation. A progressive loss of retinal function was found in both mutant groups, with significantly reduced visual acuity from 3 months of age in Prph2KI/KI mice and from 6 months of age in Prph2WT/KI mice. Decreased amplitudes in the electroretinography responses were observed from 1 month of age in Prph2KI/KI mice and from 6 months of age in Prph2WT/KI mice. Morphological analysis of the retinas correlated with functional findings, showing a progressive decrease in retinal thickness of mutant mice, with earlier and more severe changes in the homozygous mutant mice. We corroborated the alteration of the outer segment structure, and we found changes in the synaptic connectivity in the outer plexiform layer as well as gliosis and signs of microglial activation. The new Prph2WT/KI and Prph2KI/KI murine models show a pattern of retinal degeneration similar to that described in human patients with central areolar choroidal dystrophy and appear to be good models to study the mechanisms involved in the onset and progression of the disease, as well as to test the efficacy of new therapeutic strategies.
Wafer-scale organic-on-III-V monolithic heterogeneous integration for active-matrix micro-LED displays
Authors: Han Lei , Ogier Simon , Li Jun , Sharkey Dan , Yin Xiaokuan , Baker Andrew , Carreras Alejandro , Chang Fangyuan , Cheng Kai , Guo Xiaojun 
Published: November 2023

AbstractThe organic thin-film transistor is advantageous for monolithic three-dimensional integration attributed to low temperature and facile solution processing. However, the electrical properties of solution deposited organic semiconductor channels are very sensitive to the substrate surface and processing conditions. An organic-last integration technology is developed for wafer-scale heterogeneous integration of a multi-layer organic material stack from solution onto the non-even substrate surface of a III-V micro light emitting diode plane. A via process is proposed to make the via interconnection after fabrication of the organic thin-film transistor. Low-defect uniform organic semiconductor and dielectric layers can then be formed on top to achieve high-quality interfaces. The resulting organic thin-film transistors exhibit superior performance for driving micro light emitting diode displays, in terms of milliampere driving current, and large ON/OFF current ratio approaching 1010 with excellent uniformity and reliability. Active-matrix micro light emitting diode displays are demonstrated with highest brightness of 150,000 nits and highest resolution of 254 pixels-per-inch.
Reconfigurable self-assembly of photocatalytic magnetic microrobots for water purification
Authors: Urso Mario , Ussia Martina , Peng Xia , Oral Cagatay M. , Pumera Martin 
Published: November 2023

AbstractThe development of artificial small-scale robotic swarms with nature-mimicking collective behaviors represents the frontier of research in robotics. While microrobot swarming under magnetic manipulation has been extensively explored, light-induced self-organization of micro- and nanorobots is still challenging. This study demonstrates the interaction-controlled, reconfigurable, reversible, and active self-assembly of TiO2/α-Fe2O3 microrobots, consisting of peanut-shaped α-Fe2O3 (hematite) microparticles synthesized by a hydrothermal method and covered with a thin layer of TiO2 by atomic layer deposition (ALD). Due to their photocatalytic and ferromagnetic properties, microrobots autonomously move in water under light irradiation, while a magnetic field precisely controls their direction. In the presence of H2O2 fuel, concentration gradients around the illuminated microrobots result in mutual attraction by phoretic interactions, inducing their spontaneous organization into self-propelled clusters. In the dark, clusters reversibly reconfigure into microchains where microrobots are aligned due to magnetic dipole-dipole interactions. Microrobots’ active motion and photocatalytic properties were investigated for water remediation from pesticides, obtaining the rapid degradation of the extensively used, persistent, and hazardous herbicide 2,4-Dichlorophenoxyacetic acid (2,4D). This study potentially impacts the realization of future intelligent adaptive metamachines and the application of light-powered self-propelled micro- and nanomotors toward the degradation of persistent organic pollutants (POPs) or micro- and nanoplastics.
A low-nuclear Ag4 nanocluster as a customized catalyst for the cyclization of propargylamine with CO2
Authors: Li Lin , Lv Ying , Sheng Hongting , Du Yonglei , Li Haifeng , Yun Yapei , Zhang Ziyi , Yu Haizhu , Zhu Manzhou 
Published: November 2023

AbstractThe preparation of 2-Oxazolidinones using CO2 offers opportunities for green chemistry, but multi-site activation is difficult for most catalysts. Here, A low-nuclear Ag4 catalytic system is successfully customized, which solves the simultaneous activation of acetylene (-C≡C) and amino (-NH-) and realizes the cyclization of propargylamine with CO2 under mild conditions. As expected, the Turnover Number (TON) and Turnover Frequency (TOF) values of the Ag4 nanocluster (NC) are higher than most of reported catalysts. The Ag4* NC intermediates are isolated and confirmed their structures by Electrospray ionization (ESI) and 1H Nuclear Magnetic Resonance (1H NMR). Additionally, the key role of multiple Ag atoms revealed the feasibility and importance of low-nuclear catalysts at the atomic level, confirming the reaction pathways that are inaccessible to the Ag single-atom catalyst and Ag2 NC. Importantly, the nanocomposite achieves multiple recoveries and gram scale product acquisition. These results provide guidance for the design of more efficient and targeted catalytic materials.
Accelerated deprotonation with a hydroxy-silicon alkali solid for rechargeable zinc-air batteries
Authors: Wang Yaobin , Ge Xinlei , Lu Qian , Bai Wenjun , Ye Caichao , Shao Zongping , Bu Yunfei 
Published: November 2023

AbstractTransition metal oxides are promising electrocatalysts for zinc-air batteries, yet surface reconstruction caused by the adsorbate evolution mechanism, which induces zinc-ion battery behavior in the oxygen evolution reaction, leads to poor cycling performance. In this study, we propose a lattice oxygen mechanism involving proton acceptors to overcome the poor performance of the battery in the OER process. We introduce a stable solid base, hydroxy BaCaSiO4, onto the surfaces of PrBa0.5Ca0.5Co2O5+δ perovskite nanofibers with a one-step exsolution strategy. The HO-Si sites on the hydroxy BaCaSiO4 significantly accelerate proton transfer from the OH* adsorbed on PrBa0.5Ca0.5Co2O5+δ during the OER process. As a proof of concept, a rechargeable zinc-air battery assembled with this composite electrocatalyst is stable in an alkaline environment for over 150 hours at 5 mA cm–2 during galvanostatic charge/discharge tests. Our findings open new avenues for designing efficient OER electrocatalysts for rechargeable zinc-air batteries.