bluuebunny/crossref_metadata_2025_split huggingface dataset:
Minimally invasive segmentectomy and lobectomy for peripheral stage IA1–2 non-small-cell lung cancer: a case-matched cohort study from a UK Centre
Authors: Brunelli Alessandro , Rushwan Amr , Stefanou Demetrios , Drosos Polivious , Chaudhuri Nilanjan , Milton Richard , Tcherveniakov Peter , Papagiannopoulos Kostas , Valuckiene Laura 
Published: December 2023

Abstract

OBJECTIVES
The objective of this study is to compare in a real-world series the short- and long-term results of segmentectomy and lobectomy for peripheral clinical stage IA non-small-cell lung cancer (NSCLC).

METHODS
Single-centre cohort study including a series of consecutive patients undergoing minimally invasive segmentectomy or lobectomy for peripheral (outer third of the lung) clinical stage IA NSCLC (January 2017–August 2022). Propensity score case matching analysis generated 2 matched groups of patients undergoing segmentectomy or lobectomy. Short-term (morbidity and mortality) and long-term [overall survival and event-free survival (EFS)] outcomes were compared between the 2 matched groups. EFS was calculated by including death resulting from any cause and any recurrence as events.

RESULTS
Propensity score generated 118 pairs of patients undergoing minimally invasive segmentectomy or lobectomy. The median follow-up was 30 months (95% confidence limits (CL) 4–64). The median postoperative length of stay was 4 days in both groups. Ninety-day mortality was similar (segmentectomy 2.5% versus lobectomy 1.7%, P = 1). Three-year overall survival [segmentectomy 87% (76–93) versus lobectomy 81% (72–88), P = 0.73] and EFS [segmentectomy 82% (72–90) versus lobectomy 78% (68–84), P = 0.52] did not differ between the groups. Loco-regional recurrence rate [segmentectomy 4.2% (5/118) versus lobectomy 9.3% (11/118), P = 0.19] was similar despite a lower nodal upstaging [segmentectomy 3.4% (4/118) versus lobectomy 14% (17/118), P = 0.005]. The occurrence of compromised resection margins (pR1 or pR uncertain) was similar between the groups [segmentectomy 7.6% (9/118) versus lobectomy 9.3% (11/118), P = 0.81].

CONCLUSIONS
This observational series confirms the non-inferiority of segmentectomy compared to lobectomy in treating peripherally located stage IA NSCLC.
A new species of stygobitic Hyalella Smith, 1874 (Amphipoda: Hyalellidae) from Ash Meadows National Wildlife Refuge, Nevada, USA, with discussion of the unique presence of the species in the Nearctic groundwater fauna
Authors: Cannizzaro Andrew G , Lange Corey J , Berg David J 
Published: December 2023

Abstract
A new species of stygobitic hyalellid amphipod, Hyalella cretaen. sp., is described from Ash Meadows National Wildlife Refuge, Nye County, Nevada, USA, based on both morphological and molecular comparisons to congeners. These data identify H. cretaen. sp. as distinct when compared to allied species. Along with the similar Hyalella muertaBaldinger, Shepard & Threloff, 2000, H. cretaen. sp. marks the second described stygobitic species of Hyalella from the Nearctic. The occurrence of the genus in groundwater in the Nearctic is enigmatic, especially when compared to other more wide-ranging stygobites (e.g., Stygobromus spp., Hadziidae spp.). The biogeographic implications of the occurrence of species like H. muerta and H. cretaen. sp. in relation to other Nearctic stygobites is discussed.
Exploration of adverse consequences of total knee arthroplasty by patients and knee specialists: a qualitative study
Authors: te Molder Malou E M , Vriezekolk Johanna E , van Onsem Stefaan , Smolders José M H , Heesterbeek Petra J C , van den Ende Cornelia H M 
Published: December 2023

Abstract

Objectives
A successful outcome according to the knee specialist is not a guarantee for treatment success as perceived by patients. In this study, we aimed to explore outcome expectations and experiences of patients with OA before and after total knee arthroplasty (TKA) surgery and knee specialists that might contribute to the negative appraisal of its effect, and differences in views between patients and knee specialists.

Methods
Semi-structured interviews were held in Belgium and the Netherlands. Twenty-five patients (2 without indications for TKA, 11 on the waiting list for TKA and 12 postoperative TKA) and 15 knee specialists (9 orthopaedic surgeons, 1 physician assistant, 1 nurse practitioner and 4 physiotherapists) were interviewed. Conversations were audio recorded, transcribed verbatim, and analysed using thematic analysis following the grounded theory approach. Separate analyses were conducted for patients and knee specialists.

Results
Patients were focused on the arduous process of getting used to the prosthesis, lingering pain, awareness of the artificial knee and limitations they experience during valued and daily activities, whereas knee specialists put emphasis on surgical failure, unexplained pain, limited walking ability and impairments that limit the physical functioning of patients.

Conclusion
This study provides a comprehensive overview of potential adverse consequences from the perspective of both patients and knee specialists. Improving patients’ awareness and expectations of adaptation to the knee prosthesis needs to be considered.
Estimation of diagnostic reference levels for pediatric head computed tomography in Yaoundé
Authors: Kamdem Eddy F , Fotue Alain J , Kouam Brice B F , Abogo Serge , Samba Odette N 
Published: December 2023

Abstract
The diagnostic reference levels (DRLs) are determined from dosimetry studies to compare and manage patient doses in medical imaging procedures. The aim of this work was to establish the first DRLs for pediatric patients during the most common computed tomography (CT) procedures in Yaoundé, Cameroon during routine head CT examinations to know how to improve our clinical practice tomorrow. The sample was classified per age group: ≤ 1-, 1–5-, 5–10- and 10–15-y-old. The retrospective study was used. The proposed DRLs were defined as 75th percentile of the median values of the distributions. In terms of Volume CT Dose Index (CTDIvol) and dose length product (DLP), the DRLs obtained for the ages groups were: 28.6 mGy and 545.8 mGy.cm, 32.6 mGy and 735 mGy.cm, 37.1 mGy and 761.6 mGy.cm and 44.2 mGy and 1081.2 mGy.cm, respectively. DRLs in Yaoundé for DLP were higher than those of comparison literatures. The Yaoundé CTDIvol was higher than the comparison literatures except for the IAEA (2015) values for the three older age groups. The DRLs reported in Yaoundé were compared to Morocco 2020, Switzerland 2018, IAEA 2015 and Iran 2020 values. The estimation of this first DRL for pediatric head CT scan in Yaoundé must be a starting point to spread this investigation towards other examinations and imaging modalities across the country. Therefore, optimization of the CT scan procedures and orderly updates of local DRLs are necessary to improve radioprotection.
Dose effect of Actisaf Sc 47 yeast probiotic (Saccharomyces cerevisiae) supplementation on production, reproduction, and negative energy balance in early lactation dairy cows
Authors: Kumprechtová Dana , Legendre Héloïse , Kadek Romana , Nenov Valentin , Briche Maxime , Salah Nizar , Illek Josef 
Published: December 2023

Abstract
The study evaluated the dose effect of dietary supplementation with yeast probiotic Saccharomyces cerevisiae (CNCM I-4407, 1010 CFU/g, Actisaf Sc 47; Phileo by Lesaffre, France) on production, energy metabolism, and reproduction in lactating dairy cows. About 117 multiparous Holstein cows from 3 to 60 d in milk held in a barn with an automatic milking system were enrolled in a randomized complete block design and blocked according to calving day, parity, and previous milk yield. The cows were assigned to a basal diet (15% CP, 22% starch) plus either 5 g (Y5 group, n = 39), 10 g (Y10 group, n = 39), or 0 g (CON, n = 39) of yeast probiotic, presented on top of concentrate fed in the robot. Milk yield and body weight were recorded daily, milk composition, and somatic cell count (SSC) every 2 wk, and body condition score (BCS) was estimated at days −14, 14, and 40 post-calving. Data were analyzed using a linear mixed model. The Y10 group showed an increased average daily yield of energy-corrected milk (ECM) over CON (+3.5 kg, P &lt; 0.05) and Y5 (+0.8 kg). There were no significant differences between the groups in milk fat, milk protein, milk SCC linear score, milk urea, blood beta-hydroxy-butyric acid levels, and BCS. Body weight loss from 3 to 90 d in milk was numerically lower (13.8 kg) in Y5 than in CON (25.3 kg), and the success rate from the first insemination was the highest in YP5 and YP10 groups (39%) than in Control (26%). The yeast probiotic supplementation to early lactation high-producing dairy cows showed a clear effect of the high dose (10 g) on ECM milk production, although the lower dose (5 g) showed only numerical ECM production increase, both doses displayed better use of energy from the diet than the control and suggest a better resource efficiency.
The Telltale Botox: Botulinum Toxin Injection by an Expert Hand as an Intracranial Aneurysm Detector
Authors: Caddia Giorgio , Jaber Giulio J. , Granata Francesca , Galletta Karol , Pitrone Antonio , La Spina Paolino , Stagno d’Alcontres Ferdinando , Stagno d’Alcontres Francesco 
Published: December 2023

Summary:
Complications in aesthetic medicine can be considered a consequence of the inexperience of the performing physician, but in some cases, they can unveil far more serious conditions, hitherto silent. We present a case of a 48-year-old patient who, following botulinum toxin type A (Botox) injection for treatment of forehead wrinkles, returned to our attention 12 days later for a discrete, newly onset right eyelid ptosis. This ptosis was a telltale sign of the presence of an intracranial aneurysm closely related with the oculomotor nerve. The lack of compensatory action by the frontalis muscle in maintaining the eyelid in position allowed us to highlight the extrinsic compression deficit of the oculomotor nerve. Subsequently, the patient underwent endovascular treatment of the aneurysm, leading to complete resolution of the case.
Can AI Think Like a Plastic Surgeon? Evaluating GPT-4’s Clinical Judgment in Reconstructive Procedures of the Upper Extremity
Authors: Leypold Tim , Schäfer Benedikt , Boos Anja , Beier Justus P. 
Published: December 2023

Summary:
This study delves into the potential application of OpenAI’s Generative Pretrained Transformer 4 (GPT-4) in plastic surgery, with a particular focus on procedures involving the hand and arm. GPT-4, a cutting-edge artificial intelligence (AI) model known for its advanced chat interface, was tested on nine surgical scenarios of varying complexity. To optimize the performance of GPT-4, prompt engineering techniques were used to guide the model’s responses and improve the relevance and accuracy of its output. A panel of expert plastic surgeons evaluated the responses using a Likert scale to assess the model’s performance, based on five distinct criteria. Each criterion was scored on a scale of 1 to 5, with 5 representing the highest possible score. GPT-4 demonstrated a high level of performance, achieving an average score of 4.34 across all cases, consistent across different complexities. The study highlights the ability of GPT-4 to understand and respond to complicated surgical scenarios. However, the study also identifies potential areas for improvement. These include refining the prompts used to elicit responses from the model and providing targeted training with specialized, up-to-date sources. This study demonstrates a new approach to exploring large language models and highlights potential future applications of AI. These could improve patient care, refine surgical outcomes, and even change the way we approach complex clinical scenarios in plastic surgery. However, the intrinsic limitations of AI in its current state, together with the potential ethical considerations and the inherent uncertainty of unanticipated issues, serve to reiterate the indispensable role and unparalleled value of human plastic surgeons.
CHOROIDAL OSTEOMA IN AN INFANT
Authors: Eder Adrianna E. , Bostwick Karina , Wells Jill R. , Hubbard G. Baker 
Published: December 2023

Purpose:
The aim of this study was to describe a case of choroidal osteoma with macular involvement in an infant who was treated with transpupillary thermotherapy.

Methods:
This was a case report.

Results:
An 11-month-old infant presented for retinopathy of prematurity follow-up examination and was found to have a three disk-diameter round, orange, subretinal, slightly elevated lesion with well-defined margins in the superior macula of the left eye. B-scan ultrasonography showed a slightly elevated, highly reflective choroidal mass with acoustic shadowing. A diagnosis of choroidal osteoma was made. Six months later, repeat examination under anesthesia showed the lesion to be increasing in size and encroaching on the fovea. Given demonstrated growth and the risk of central vision loss, the patient was treated with transpupillary thermotherapy. Subsequent EUAs, over a period of 4 months, have shown complete decalcification with no subsequent growth.

Conclusion:
Choroidal osteomas are benign lesions that can be sight-threatening if located in the macula. Transpupillary thermotherapy in this case resulted in complete regression of a sight-threatening extrafoveal choroidal osteoma at 4-month follow-up.
ANCA-associated vasculitis: overview and practical issues of diagnosis and therapy from a European perspective
Authors: Duarte Ana Catarina , Ribeiro Rui , Macedo Ana M. , Santos Maria José 
Published: December 2023

Abstract
Antineutrophil cytoplasmic antibodies (ANCA)–associated vasculitis (AAV) is a heterogeneous group of rare diseases characterized by necrotizing inflammation predominantly of small vessels and the presence of these circulating antibodies. AAV comprises three important diseases, namely granulomatosis with polyangiitis, microscopic polyangiitis, and eosinophilic granulomatosis with polyangiitis, which affect multiple organ systems, significantly affecting patients' quality of life and survival. The diagnosis is established according to the clinical manifestations, detectable ANCA, and histopathology findings. Primary treatment strategies are adapted to the severity of the disease and based on immunosuppression with corticosteroids and cyclophosphamide, with increasing adoption of new, less toxic agents aimed at sustained remission of the disease, such as rituximab, methotrexate, and mycophenolate mofetil. Several international medical organizations have proposed recommendations for diagnosing and managing these diseases to standardize the procedures. In this study, we provide an up-to-date European perspective on AAV management, compiling current and relevant information regarding its epidemiology, symptoms, diagnosis, treatment strategies, and prognosis.
Matrix factorizations and pentagon maps
Authors: Kassotakis Pavlos 
Published: December 2023

We propose a specific class of matrices that participate in factorization problems that turn out to be equivalent to constant and entwining (non-constant) pentagon, reverse-pentagon or Yang–Baxter maps, expressed in non-commutative variables. In detail, we show that factorizations of order

N
=
2

matrices of this specific class are equivalent to the
homogeneous normalization map
. From order

N
=
3

matrices, we obtain an extension of the homogeneous normalization map, as well as novel entwining pentagon, reverse-pentagon and Yang–Baxter maps.
Helicobacter pylori Isolate from Endoscopy Examined Patients in Bahir Dar, North West Ethiopia Helicobacter pylori Isolate from Endoscopy Examined Patients in Bahir Dar, North West Ethiopia
Authors: Erkihun Mulat , Chanie Desalegn Nigatu , Siraj Yesuf Adem 
Published: December 2023

Background: The Helicobacter pylori infection is highly prevalent throughout the world and causes gastric-associated diseases. Its microbial niche is the stomach, where it causes different abnormalities while being observed. As a result, the current study sought to determine the magnitude and effects of Helicobacter pylori in patients who underwent endoscopic examination. Method: An institution-based cross-sectional study was conducted from January to May 2019 at endoscopy service-providing health institutions. Socio-demographic and clinical data were collected using a pretested, structured questionnaire. Gastric biopsies were collected according to the Sydney protocol during endoscopic procedures and immediately inoculated into brain-heart infusion broth. Data were entered and analyzed using SPSS version 23. Result: Among the 135 study participants, 59.3% were males and 40.7% were females, with a mean age of 45 years old. The proportion of Helicobacter pylori isolated was 17.8% (24/135). The majority of isolates (71% of 17/24) were from males, while only 29% of 7/24) were from females. Isolation of Helicobacter pylori was significantly associated with a high salt intake habit [AOR = 3.3, 95% CI = (1.5, 10.8), P = 0.04] and the presence of a duodenal ulcer [AOR = 3.8, 95% CI = (1.2, 11.9), P = 0.02. The highest proportion of Helicobacter pylori had been observed in patients with atrophic pan gastritis. Conclusion: The prevalence of Helicobacter pylori isolated from the study participants was relatively lower. High salt intake and the presence of duodenal ulcers are significantly associated with Helicobacter pylori infection. Key words: Endoscopy, Gastric associated diseases, Gastritis, Duodenal ulcer, Helicobacter pylori
comradesOO: An Object-Oriented R Package for the Analysis of RNA Structural Data Generated by RNA crosslinking experiments
Authors: Price Jonathan L. , Ziv Omer , Pinckert Malte L. , Miska Eric A. 
Published: December 2023

AbstractSummaryRNA (Ribonucleic Acid) molecules have secondary and tertiary structuresin vivowhich play a crucial role in cellular processes such as the regulation of gene expression, RNA processing, and localization. The ability to investigate these structures will enhance our understanding of their function and contribute to the diagnosis and treatment of diseases caused by RNA dysregulation. However, there are no mature pipelines or packages for processing and analysing complexin vivoRNA structural data. Here, we present COMRADES Object-Oriented (comradesOO), a novel software package for the comprehensive analysis of data derived from the COMRADES (Crosslinking of Matched RNA and Deep Sequencing) method. comradesOO offers a comprehensive pipeline from raw sequencing reads to the identification of RNA structural features. It includes read processing and alignment, clustering of duplexes, data exploration, folding and comparisons of RNA structures. comradesOO also enables comparisons between conditions, the identification of inter-RNA interactions, and the incorporation of reactivity data to improve structure prediction.Availability and ImplementationcomradesOO is freely available to non-commercial users and implemented in R, with the source code and documentation accessible at [https://CRAN.R-project.org/package=comradesOO]. The software is supported on Linux, macOS, and Windows platforms.Contactjlp76@cam.ac.ukSupplementary informationSupplementary data are available atBioinformaticsonline.
Blocking Orai1 constitutive activity inhibits B-cell cancer migration and synergistically acts with drugs to reduce B-CLL cell survival
Authors: Scaviner Julien , Bagacean Cristina , Christian Berthou , Renaudineau Yves , Mignen Olivier , Abdoul-Azize Souleymane 
Published: December 2023

AbstractOrai1 channel capacity to control store-operated Ca2+entry (SOCE) and B-cell functions is poorly understood and more specifically in B-cell cancers, including human lymphoma and leukemia. As compared to normal B-cells, Orai1 is overexpressed in B-chronic lymphocytic leukemia (B-CLL) and contributes in resting B-CLL to mediate an elevated basal Ca2+level through a constitutive Ca2+entry, and in BCR-activated B-cell to regulate the Ca2+signaling response. Such observations were confirmed in human B-cell lymphoma and leukemia lines, including RAMOS, JOK-1, MEC-1 and JVM-3 cells. Next, the use of pharmacological Orai1 inhibitors (GSK-7975A and Synta66) blocks constitutive Ca2+entry and in turn affects B-cell cancer (primary and cell lines) survival and migration, controls cell cycle, and induces apoptosis through a mitochondrial and caspase-3 independent pathway. Finally, the added value of Orai1 inhibitors in combination with B-CLL drugs (ibrutinib, idelalisib, rituximab, and venetoclax) on B-CLL survival was tested, showing an additive/synergistic effect including in the B-cell cancer lines. To conclude, this study highlights the pathophysiological role of the Ca2+channel Orai1 in B-cell cancers, and pave the way for the use of ORAI1 modulators as a plausible therapeutic strategy.
Expression and DNA methylation of 20S proteasome subunits as prognostic and resistance markers in cancer
Authors: Al-Abdulla Ruba , Venz Simone , Al-Ali Ruslan , Wendlandt Martin , Radefeldt Mandy , Krüger Elke 
Published: December 2023

ABSTRACTProteasomes are involved in the maintenance of cellular protein homeostasis and the control of numerous cellular pathways. Single proteasome genes or subunits have been identified as important players in cancer development and progression without considering the proteasome as a multi-subunit protease. We here conduct a comprehensive pan-cancer analysis encompassing transcriptional, epigenetic, mutational landscapes, pathway enrichments, and survival outcomes linked to the 20S proteasome core complex. The impact of proteasome gene expression on patient survival exhibits a cancer-type dependent pattern. Escalated proteasome expression associates with elevated activation of oncogenic pathways, such as DNA repair, MYC- controlled gene networks, MTORC1 signaling, oxidative phosphorylation, as well as metabolic pathways including glycolysis and fatty acid metabolism. Vice versa, potential loss of function variants correlates with improved survival. The TCGA-derived outcomes are further supported by gene expression analysis of THP-1 cells. Our study reframes these subunits as an integrated functional ensemble, rather than separated subunits.Abstract Figure
Exploring consumer attitudes and behaviour towards sustainable health-related food choices
Authors: Chamhuri Norshamliza , Che Lah Nur Syahirah , Batt Peter J. , Ramlan Muhammad Nadzif Bin , Mod Asri Norain , Abdullah Al-Hadi Azrina 
Published: December 2023

PurposePalm oil has consistently been a staple ingredient in the Malaysian diet. Despite various promotional efforts throughout the years, the health aspects of palm oil have often been undervalued, leading consumers to overlook its benefits. This study has two objectives: (1) to explore consumer behaviour in purchasing decisions for food products containing palm oil in an emerging market and (2) to examine consumer awareness of palm oil as an ingredient in various edible products related to health.Design/methodology/approachA quantitative methodology that utilises a self-administered questionnaire was adopted for data collection. The conceptual framework and hypotheses were tested using partial least squares (PLS) structural equation modelling (SEM) on a dataset of 342 respondents.FindingsThe findings revealed that three hypotheses – attitude, subjective norms (SNs) and perceived health benefits – positively impact the intention to purchase palm-oil-based food products. Additionally, results indicate that Malaysian consumers practice sustainable consumption when purchasing palm-oil-based food products.Originality/valueThere is a need for a greater understanding of the importance perceived health benefits have in influencing consumers' consumption of food products containing palm oil in an emerging market such as Malaysia. This research study addresses the gap in existing knowledge.